bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fast and robust visual odometry with a low-cost IMU in dynamic environments
Authors: Yao Erliang , Zhang Hexin , Song Haitao , Zhang Guoliang 
Published: September 2019

Purpose
To realize stable and precise localization in the dynamic environments, the authors propose a fast and robust visual odometry (VO) approach with a low-cost Inertial Measurement Unit (IMU) in this study.

Design/methodology/approach
The proposed VO incorporates the direct method with the indirect method to track the features and to optimize the camera pose. It initializes the positions of tracked pixels with the IMU information. Besides, the tracked pixels are refined by minimizing the photometric errors. Due to the small convergence radius of the indirect method, the dynamic pixels are rejected. Subsequently, the camera pose is optimized by minimizing the reprojection errors. The frames with little dynamic information are selected to create keyframes. Finally, the local bundle adjustment is performed to refine the poses of the keyframes and the positions of 3-D points.

Findings
The proposed VO approach is evaluated experimentally in dynamic environments with various motion types, suggesting that the proposed approach achieves more accurate and stable location than the conventional approach. Moreover, the proposed VO approach works well in the environments with the motion blur.

Originality/value
The proposed approach fuses the indirect method and the direct method with the IMU information, which improves the localization in dynamic environments significantly.
How does servitisation affect supply chain circularity? – A systematic literature review
Authors: Kühl Carl , Bourlakis Michael , Aktas Emel , Skipworth Heather 
Published: September 2019

PurposeThe purpose of this paper is to test the link between servitisation and circular economy by synthesising the effect of product-service systems (PSS) on supply chain circularity (SCC).Design/methodology/approachFollowing a systematic literature review methodology, the study identified 67 studies and synthesised them using content analysis.FindingsA conceptual model is developed illustrating how PSS business models impact SCC through increased product longevity, closure of resource loops and resource efficiency. It also identifies six contextual factors affecting the implementation of SCC including: economic attractiveness of SCC; firm sustainability strategy; policy and societal environment; product category; supply chain relationships; and technology.Research limitations/implicationsThe conceptual model proposes that SCC increases with servitisation. It also proposes that the main circularity effect stems from increased product longevity, followed by closed resource loops and finally resource efficiency. The model is deduced from the literature by using secondary data.Practical implicationsThe review provides practitioners with a framework to increase SCC through PSS business models. It also gives insight into the various contextual factors that may affect how a manufacturer’s servitisation strategy contributes to SCC.Originality/valueThis review contributes to the understanding of the relationship between servitisation and SCC by synthesising the different effects that exist. Moreover, it creates new knowledge by identifying a range of contextual factors affecting the relationship between PSS and SCC.
Developing and analyzing framework to manage resources in humanitarian logistics
Authors: Ahmed Waqar , Najmi Arsalan , Khan Farhana , Aziz Hasan 
Published: September 2019

PurposeHumanitarian services usually perform in the face of uncertainty in which mobilization of resources in an efficient and effective manner is a big challenge. Sharing timely and correct information among logistics partners and workers is a key to drive rapid response logistics effectively. The purpose of this paper is to understand how coordinated effort effects resources management (RM).Design/methodology/approachThis study uses quantitative research methodology and collected data from 82 humanitarian workers dealing with logistical activities from a densely populated city of Pakistan. Data were then statistically analyzed through partial least squares–structural equation modeling.FindingsThe results suggest that the success of humanitarian supply network depends upon the level of trust among the partners, which accelerates commitment through strong coordination. Information sharing reduces behavioral uncertainty and enhances swift trust (ST). ST then helps to improve coordination and commitment from all stakeholders in order to manage resources to lead effective relief operations.Practical implicationsThe study guides the practitioners and relief operations’ policy makers to lay emphasis on distributing right and timely information flow among the partners, which can lead to effective, efficient and swift humanitarian relief operations.Originality/valueThis study on RM during humanitarian logistics is well timed in the context of developing country with high uncertain events, improper infrastructure and very limited resources.
Social network analysis in humanitarian logistics research
Authors: Tacheva Zhasmina , Simpson Natalie 
Published: September 2019

PurposeThe purpose of this paper is to promote social network analysis (SNA) methodology within the humanitarian research community, surveying its current state of the art and demonstrating its utility in analyzing humanitarian operations.Design/methodology/approachA comprehensive survey of the related literature motivates a proposed agenda for interested researchers. Analysis of two humanitarian networks in Afghanistan demonstrates the use and utility of SNA, based on secondary data. In the second case study, the use of random graphs to detect network motifs is demonstrated using Monte Carlo simulation to create the benchmark null sets.FindingsSNA is an adaptable and highly useful methodology in humanitarian research, quantifying patterns of community structure and collaboration among humanitarian organizations. Network motifs suggesting distinct affinity between particular agencies within humanitarian clusters are observed.Research limitations/implicationsThe authors summarize common challenges of using SNA in humanitarian research and discuss ways to alleviate them.Practical implicationsPractitioners can use SNA as readily as researchers, to visualize existing networks, identify areas of concern and better communicate observations.Social implicationsBy making SNA more accessible to a humanitarian research audience, the authors hope its ability to capture complex, dynamic relationships will advance understanding of effective humanitarian relief systems.Originality/valueTo the best of knowledge, it is the first study to conduct a systematic analysis of the application of SNA in empirical humanitarian research and outline a concrete SNA-based research agenda. This is also a currently rare instance of a humanitarian study using random graphs to assess observed SNA measures.
Feasibility study on molecularly imprinted assays for biomedical diagnostics
Authors: Ang Qian Yee , Low Siew Chun 
Published: September 2019

Purpose
Molecularly imprinted polymers (MIPs) have aroused focus in medicinal chemistry in recent decades, especially for biomedical applications. Considering the exceptional abilities to immobilize any guest of medical interest (antibodies, enzymes, etc.), MIPs is attractive to substantial research efforts in complementing the quest of biomimetic recognition systems. This study aims to review the key-concepts of molecular imprinting, particularly emphasizes on the conformational adaptability of MIPs beyond the usual description of molecular recognition. The optimal morphological integrity was also outlined in this review to acknowledge the successful sensing activities by MIPs.

Design/methodology/approach
This review highlighted the fundamental mechanisms and underlying challenges of MIPs from the preparation stage to sensor applications. The progress of electrochemical and optical sensing using molecularly imprinted assays has also been furnished, with the evolvement of molecular imprinting as a research hotspot.

Findings
The lack of standard synthesis protocol has brought about an intriguing open question in the selection of building blocks that are biocompatible to the imprint species of medical interest. Thus, in this paper, the shortcomings associated with the applications of MIPs in electrochemical and optical sensing were addressed using the existing literature besides pointing out possible solutions. Future perspectives in the vast development of MIPs also been postulated in this paper.

Originality/value
The present review intends to furnish the underlying mechanisms of MIPs in biomedical diagnostics, with the aim in electrochemical and optical sensing while hypothesizing on future possibilities.
Does operational sex ratio influence relative strength of purging selection in males versus females?
Authors: Plesnar‐Bielak Agata , Sychta Karolina , Gaczorek Tomasz S. , Palka Joanna K. , Prus Monika A. , Prokop Zofia M. 
Published: September 2019

AbstractAccording to theory, sexual selection in males may efficiently purge mutation load of sexual populations, reducing or fully compensating ‘the cost of males’. For this to occur, mutations not only need to be deleterious to both sexes, they also must affect males more than females. A frequently overlooked problem is that relative strength of selection on males versus females may vary between environments, with social conditions being particularly likely to affect selection in males and females differently. Here, we induced mutations in red flour beetles (Tribolium castaneum) and tested their effect in both sexes under three different operational sex ratios (1:2, 1:1 and 2:1). Induced mutations decreased fitness of both males and females, but their effect was not stronger in males. Surprisingly, operational sex ratio did not affect selection against deleterious mutations nor its relative strength in the sexes. Thus, our results show no support for the role of sexual selection in the evolutionary maintenance of sex.
Variation in Wolbachia cidB gene, but not cidA, is associated with cytoplasmic incompatibility mod phenotype diversity in Culex pipiens
Authors: Bonneau Manon , Caputo Beniamino , Ligier Aude , Caparros Rudy , Unal Sandra , Perriat‐Sanguinet Marco , Arnoldi Daniele , Sicard Mathieu , Weill Mylène 
Published: September 2019

AbstractEndosymbiotic Wolbachia bacteria are, to date, considered the most widespread symbionts in arthropods and are the cornerstone of major biological control strategies. Such a high prevalence is based on the ability of Wolbachia to manipulate their hosts' reproduction. One manipulation called cytoplasmic incompatibility (CI) is based on the death of the embryos generated by crosses between infected males and uninfected females or between individuals infected with incompatible Wolbachia strains. CI can be seen as a modification‐rescue system (or mod‐resc) in which paternal Wolbachia produce mod factors, inducing embryonic defects, unless the maternal Wolbachia produce compatible resc factors. Transgenic experiments in Drosophila melanogaster and Saccharomyces cerevisiae converged towards a model where the cidB Wolbachia gene is involved in the mod function while cidA is involved in the resc function. However, as cidA expression in Drosophila males was required to observe CI, it has been proposed that cidA could be involved in both resc and mod functions. A recent correlative study in natural Culex pipiens mosquito populations has revealed an association between specific cidA and cidB variations and changes in mod phenotype, also suggesting a role for both these genes in mod diversity. Here, by studying cidA and cidB genomic repertoires of individuals from newly sampled natural C. pipiens populations harbouring wPipIV strains from North Italy, we reinforce the link between cidB variation and mod phenotype variation fostering the involvement of cidB in the mod phenotype diversity. However, no association between any cidA variants or combination of cidA variants and mod phenotype variation was observed. Taken together our results in natural C. pipiens populations do not support the involvement of cidA in mod phenotype variation.
Azole resistance in Aspergillus species in Southern Taiwan: An epidemiological surveillance study
Authors: Chen Yi‐Chun , Kuo Shu‐Fang , Wang Hsuan‐Chen , Wu Chi‐Jung , Lin Yin‐Shiou , Li Wei‐Sin , Lee Chen‐Hsiang 
Published: September 2019

SummaryPoor clinical outcomes for invasive aspergillosis are associated with antifungal resistance. Performing antifungal susceptibility tests on clinically relevant Aspergillus isolates from patients and environmental regions with known azole resistance is recommended. The aim of the study was to assess the presence of azole resistance in clinical Aspergillus spp. isolates and those from hospital environments and farmlands within a 40 km radius of the hospital. Clinical Aspergillus spp. isolates were cultured, as well as environmental Aspergillus spp. isolates obtained from air samples. Samples were subcultured in azole‐containing agar plates. Isolates with a positive screening test were subjected to YeastOne methods to determine their minimum inhibitory concentrations of antifungals. Resistance mechanisms were investigated in the azole‐resistant Aspergillus spp. isolates. No azole‐resistant clinical or environmental A flavus, A oryaze, A niger or A terreus isolates were found in the present study. All A fumigatus clinical isolates were azole‐susceptible. Seven A fumigatus environmental isolates were associated with cyp51A mutations, including two that harboured TR34/L98H mutations with S297T/F495I substitutions, two with TR34/L98H mutations and three with TR46/Y121F/T289A mutations. One of these isolates was collected from farmland, one was from A ward and five were from B ward. The proportion of azole‐resistant A fumigatus was 10.2% (6/59) and 3.2% (1/31) in the hospital environments and the farmlands near the hospital, respectively. The results showed that azole‐resistant A fumigatus existed within hospital environments. This emphasises the importance of periodic surveillance in hospital environments and monitoring for the emergence of azole‐resistant A fumigatus clinical isolates.
The role of bud protection and bark density in frost resistance of savanna trees
Authors: De Antonio A. C. , Scalon M. C. , Rossatto D. R. 
Published: September 2019

Abstract

Frost events occur with a significant frequency in savannas of the Southern Hemisphere, especially in the Cerrados of Brazil. One of the main strategies to deal with such events is to invest in thick and dense bark, which can insulate internal branch tissues and protect buds, essential to ensure resprouting if frost damage causes plant canopy die‐back. Such strategies may be fundamental to determine the persistence of savanna species in regions where low temperatures and frost events are recurrent.

Here we describe bud protection and bark strategies of 53 woody species growing in typical savanna vegetation of central Brazil. In addition, we used an experimental approach exposing branches to 0 °C to measure temperature variation in internal branch tissue and test its relationship to bud protection and bark properties.

We found that the majority of species (69%) showed medium to high bud protection against extreme temperatures; however, the degree of bud protection was not clearly related to bark properties, such as bark thickness and density. Bark density is a fundamental trait in determining protection against low temperatures (0 °C), since species with low bark density showed lower temperature variation in their internal branch tissues, independently of the bud protection degree.

Bark properties and bud protection are two different (albeit related) strategies for the protection and persistence of savanna trees under extreme environmental temperatures and can explain ecological observations related to savanna tree responses after frost events.
Optimizing treatment of DNA methyltransferase inhibitor RG108 on porcine fibroblasts for somatic cell nuclear transfer
Authors: Wu Cai‐feng , Zhang De‐fu , Zhang Shushan , Sun Lingwei , Liu Ying , Dai Jian‐jun 
Published: September 2019

AbstractAberration in DNA methylation is believed to be one of the major causes of abnormal gene expression and inefficiency of somatic cell nuclear transfer (SCNT). RG108, a non‐nucleoside DNA methyltransferase (DNMT) inhibitor, has been reported to facilitate somatic nuclear reprogramming and improved blastocyst formation. The aim of this study was to investigate interaction effect of RG108 treatment time (24–72 hr) and concentrations (0.05–50 µM) on donor cells, and further to optimize the treatment for porcine SCNT. Our results showed that RG108 treatment resulted in time‐dependent decrease of genome‐wide DNA methylation on foetal fibroblasts, which only happened after 72‐hr treatment in our experiments, and no interaction effect between treatment time and concentration. Remarkable decrease of methylation in imprinted gene H19 and increased apoptosis was observed in 5 and 50 µM RG108‐treated cells. Furthermore, the blastocyst rates of SCNT embryos were increased as the fibroblasts treated with RG108 at 5 and 50 µM, and additional treatment during cultivation of SCNT embryos would not provide any advantage for blastocyst formation. In conclusion, the RG108 treatment of 72 hr and 5 μM would be optimized time and concentration for porcine foetal fibroblasts to improve the SCNT embryonic development. In addition, combined treatment of RG108 on donor cells and SCNT embryos would not be beneficial for embryonic development.
Relation between activity‐induced intracellular sodium transients and ATP dynamics in mouse hippocampal neurons
Authors: Gerkau Niklas J. , Lerchundi Rodrigo , Nelson Joel S. E. , Lantermann Marina , Meyer Jan , Hirrlinger Johannes , Rose Christine R. 
Published: September 2019

Key pointsEmploying quantitative Na+‐imaging and Förster resonance energy transfer‐based imaging with ATeam1.03YEMK(ATeam), we studied the relation between activity‐induced Na+influx and intracellular ATP in CA1 pyramidal neurons of the mouse hippocampus.Calibration of ATeamin situenabled a quantitative estimate of changes in intracellular ATP concentrations.Different paradigms of stimulation that induced global Na+influx into the entire neuron resulted in decreases in [ATP] in the range of 0.1–0.6 mmin somata and dendrites, while Na+influx that was locally restricted to parts of dendrites did not evoke a detectable change in dendritic [ATP].Our data suggest that global Na+transients require global cellular activation of the Na+/K+‐ATPase resulting in a consumption of ATP that transiently overrides its production.For recovery from locally restricted Na+influx, ATP production as well as fast intracellular diffusion of ATP and Na+might prevent a local drop in [ATP].AbstractExcitatory neuronal activity results in the influx of Na+through voltage‐ and ligand‐gated channels. Recovery from accompanying increases in intracellular Na+concentrations ([Na+]i) is mainly mediated by the Na+/K+‐ATPase (NKA) and is one of the major energy‐consuming processes in the brain. Here, we analysed the relation between different patterns of activity‐induced [Na+]isignalling and ATP in mouse hippocampal CA1 pyramidal neurons by Na+imaging with sodium‐binding benzofurane isophthalate (SBFI) and employing the genetically encoded nanosensor ATeam1.03YEMK(ATeam).In situcalibrations demonstrated a sigmoidal dependence of the ATeam Förster resonance energy transfer ratio on the intracellular ATP concentration ([ATP]i) with an apparentKDof 2.6 mm, indicating its suitability for [ATP]imeasurement. Induction of recurrent network activity resulted in global [Na+]ioscillations with amplitudes of ∼10 mm, encompassing somata and dendrites. These were accompanied by a steady decline in [ATP]iby 0.3–0.4 mmin both compartments. Global [Na+]itransients, induced by afferent fibre stimulation or bath application of glutamate, caused delayed, transient decreases in [ATP]ias well. Brief focal glutamate application that evoked transientlocalNa+influx into a dendrite, however, did not result in a measurable reduction in [ATP]i. Our results suggest that ATP consumption by the NKA following global [Na+]itransients temporarily overrides its availability, causing a decrease in [ATP]i. Locally restricted Na+transients, however, do not result in detectable changes in local [ATP]i, suggesting that ATP production, together with rapid intracellular diffusion of both ATP and Na+from and to unstimulated neighbouring regions, counteracts a local energy shortage under these conditions.
Pinning down variables, and taking an agile approach
Authors: Hill Robin K. , Torres Edwin 
Published: September 2019

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Robin K. Hill tries to better define variables, while Edwin Torres acknowledges he is his own greatest obstacle.
Comparison of bleeding risks among non-vitamin K antagonist oral anticoagulants using the Korea adverse event reporting system database
Authors: Ko Young-Jin , Kim Seonji , Park Kyounghoon , Kim Minsuk , Yang Bo Ram , Lee Joongyub , Kim Mi-Sook , Park Byung-Joo 
Published: September 2019

Background: In order to ensure safer use of non-vitamin K antagonist oral anticoagulants (NOACs), continuously detecting unexpected adverse drug reactions (ADRs) after market approval is necessary. Methods: We performed disproportionality analysis to evaluate association between ADRs and NOACs including apixaban, dabigatran, and rivaroxaban using data from the Korea Institute of Drug Safety and Risk Management–Korea Adverse Event Reporting System database (KIDS-KD) between 2012 and 2016. There was no significant signal other than bleeding when considering quantity, signal strength, seriousness, and causality. In order to evaluate the NOAC reports about bleeding, we selected 62 WHO-ART diagnostic codes associated with bleeding. Among the 26 codes that referred to major bleeding, 18 codes referred to gastrointestinal bleeding and 8 were referred to intracranial bleeding. We evaluated the significance of the signals using reporting odds ratios (RORs) adjusted for age and sex. Results: Treatments with apixaban, dabigatran, and rivaroxaban were associated with 1989, 1668, and 2960 adverse events, respectively. Any type of bleeding with apixaban, dabigatran, rivaroxaban, and warfarin was reported in 174 (8.8%), 209 (12.5%), 523 (17.8%), and 620 (9.5%) events, respectively. For any bleeding, adjusted RORs of apixaban, dabigatran, and rivaroxaban were 0.99 [95% confidence interval (CI): 0.83–1.17], 1.47 (95% CI: 1.25–1.75), and 2.48 (95% CI: 2.16–2.84), respectively. With respect to major bleeding, the adjusted RORs of apixaban, dabigatran, and rivaroxaban were 1.08 (95% CI: 0.82–1.41), 1.46 (95% CI: 1.10–1.90), and 1.82 (95% CI: 1.43–2.32), respectively. Conclusion: Rivaroxaban might have stronger association with bleeding than apixaban and dabigatran.