bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supply chain integration and operational performance of Kenya’s public health sector
Authors: Mbugua Anne , Namada Juliana 
Published: August 2019

This research objective is to determine the effect of the Supply Chain Integration dimensions on the operational performance of the of Kenya’s public health sector level five hospitals. The results are based on close-ended questionnaires from one hundred and sixty-four respondents working in the level five health facilities supply chain selected using simple random sampling. The data collected was subjected to completeness checks, before it was cleaned, coded, and analyzed using Statistical Package for Social Scientists (SPSS) for the generation of both descriptive and inferential statistics. The results show that Supplier integration (?1, = 0.276; p value=0.000), customer integration (?2, = 0.119; p value=0.016) and internal integration (?3, = 0.232; p value=0.000) have a significant effect on operational performance. The R2was 0.429, indicating that 42.9% of the variation in operational performance is explicated by the variation of Supply chain integration dimensions. This implies that all three supply chain integration dimensions significantly influence operational performance. The study concludes that the government needs to internally integrate and embrace forward and backward integration with the customers and suppliers to leap the full benefits of an integrated health sector to accomplish the universal health care goals.
Competitiveness of strategic food commodities in Lampung Province, Indonesia
Authors: Zakaria Wan Abbas , Endaryanto Teguh , Indah Lidyasari Mas , Marlina Lina , Listiana Indah 
Published: August 2019

Food commodities play an important role in income increase of people, job opportunities, and regional and national development. Competitiveness of food commodities needs for community welfare increase and national food security and sovereignty. The aims of this research were: (1) to analysis of competitiveness of strategic food commodities in Lampung Province, (2) to analyze the impact of changes of input and output prices against of strategic food commodities in Lampung Province, and (3) to know the policy of suitable minimum prices of strategic food commodities in Lampung Province. This research conducted in Lampung Province from September 2013 to September 2014. The regencies as a sample selected by purposive sampling were Middle Lampung, North Lampung, South Lampung, and East Lampung. The determination of the farmers used stratified simple random sampling. The sample in this study was 120 respondents. The results showed that the farming of strategic food commodities (paddy and corn) had PCR and DCR value less than one point. Strategic food commodities had lesser value due to an increase in fertilizer price and a decline in output prices. The competitiveness of strategic food commodities in Lampung Province was sensitive to output prices decrease. The policy of the minimum price of paddy at least two times greater than the price of corn.
The Role of Religious Presuppositions and Precomprehensions in Selecting Narratives Related to the Cause of Revelation (Asbab al-Nuzul)
Authors: Dashti Ali , Akbarnejad Mehdi , Hosseininia Mohammad Reza 
Published: August 2019

Abstract
The narratives of the cause of revelation (Asbab al-Nuzul) play a decisive role in the interpretation of Quranic verses. On the other hand, when coming across with these narratives, presuppositions, and precomprehensions play an important role in selecting them. This research tries to study the narratives of the cause of revelation in the Tafsir al Munir fi al Aqidah wa al Shariah wa al Manhaj (by Karya Wahbah al Zuhaili) and explain the role of Wahbah al Zuhaili’s religious presuppositions and precomprehensions in selecting narratives related to the cause of revelation (Asbab al-Nuzul). This study uses library research method that has been discussing the subject with a descriptive-analytical approach. This research shows that in many cases, Wahbah al Zuhaili has been influenced by religious presuppositions and precomprehenstion and has used them to develop his interpretative goals.
Keywords: Wahbah al Zuhaili, Tafsir al-Munir, Asbab an-Nuzul
Hak Asasi Manusia dalam Kehidupan Sosial Dalam Perspektif Al-Qur’an
Authors: Mukhoyyaroh Mukhoyyaroh 
Published: August 2019

Abstract
The Human Rights stated in the United Nation Chartered are believed to be the universal ones. Meanwhile, Alquran as the source of all life aspects of human beings including human rights. Historically, Alquran comes before the United Nation Human Rights Charter.
The main purpose of this paper is to highlight the idea that Alquran is the primary resource of human rights including the United Nation Human Rights. This study is conducted by applying qualitative library research. The result of the study emphasizes that human rights in Alquran are the basic paradigma of the human rights of the united nation due to the fundamental and essential human philosophical values coverage in the Alquran.
Keywords: Human right, Historical aspect, Human rights from an Islamic perspective.
Abstrak
Hak Asasi Manusia yang dinyatakan dalam United Nation Chartered adalah semua aspek kehidupan manusia termasuk hak asasi manusia. Secara historis, Al-Qur’an telah meletakan pondasi untuk menjunjung harkat martabat manusia dengan menghargai hak-haknya jauh sebelum Piagam Hak Asasi Manusia Perserikatan Bangsa-Bangsa. Tulisan ini membahas bagaimana al-Qur’an menyebutkna hak-hak asasi manusia yang erat kaitannya dalam kehidupan social. Penelitian ini merupakan penelitian kualitatif dengan metode studi pustaka, dengan pendekatan tasfir tematik. Hasil penelitian menekankan bahwa hak asasi manusia dalam Al-Qur’an adalah paradigma dasar dari hak asasi manusia bangsa yang bersatu karena nilai filosofis manusia yang fundamental dan esensial dalam Al-Qur’an.
Kata kunci: Hak Asasi Manusia, Historis HAM, HAM dalam Islam
Modeling of Creep-Compacting Outcrop Chalks Injected with Ca-Mg-Na-Cl Brines at Reservoir Conditions
Authors: Andersen Pål Østebø , Berawala Dhruvit Satishchandra 
Published: August 2019

Summary
Numerical and analytical 1D solutions are presented to interpret the link between geochemical alterations and creep compaction (compaction under constant effective stress) in chalk cores. Chemically reactive flow enhancing chalk compaction is of significant importance for enhanced oil recovery (EOR), compaction, and subsidence in North Sea chalk reservoirs. The focus of this study is on Ca-, Mg-, and NaCl brines that interact with the chalk by the dissolution of calcite and the precipitation of magnesite.
An explicit analytical solution is derived for the steady–state ion and dissolution–rate distributions at a given injected composition and injection rate. A mathematical description of creep compaction is proposed on the basis of applied affective stresses and rock ability to carry these stresses as a function of porosity. The reaction and compaction models are then coupled as follows: The compaction rate is assumed, which is enhanced by the dissolution rate, which can vary spatially. Furthermore, the solid volume changes by mineral dissolution and precipitation. Brine–dependent and nonuniform compaction is hence built into the model by means of the dissolution–rate distribution.
The model is validated and parameterized against data from a total of 22 core samples from two chalk types (Åalborg and Liege) where reactive and inert brines were injected from ambient to Ekofisk–reservoir conditions (130°C). Experimentally measured effluent concentrations, distributions in mineralogy after flooding, and creep–compaction behavior were matched. Our model is the first to link a vast set of data on this subject and predict performance under new experimental conditions. This also represents a first step in upscaling such results from the laboratory toward the field. Our interpretations indicate that the two chalk types would respond differently chemically and by compaction to changes in the concentration and injection rate. Brines injected through Liege chalk appeared to approach stable oversaturation, while in Åalborg, the equilibrium condition was in agreement with geochemical calculations.
Combining transversus abdominis plane block with general anesthesia blunts the perioperative stress response in patients undergoing radical gastrectomy
Authors: Liu Ruizhu , Qin Haiyan , Wang Meng , Li Kai , Zhao Guoqing 
Published: August 2019

Abstract
Background: This study aimed to assess the effect of subcostal transversus abdominis plane (TAP) block on perioperative neuroendocrine stress response, postoperative analgesia, and recovery profiles in patients undergoing radical gastrectomy with general anesthesia.
Methods: Sixty-five patients were recruited. Patients randomly received general anesthesia (control group), or general anesthesia combined with TAP block (40 mL of 0.375% ropivacaine) (TAP group). The primary endpoint was neuroendocrine levels including norepinephrine (NE), epinephrine (E), cortisol (Cor), glucose (Glu), interleukin (IL)-6 and IL-10 during 48 h after surgery. Secondary endpoints included pain score, hemodynamic variables and recovery characteristics.
Results: Data from 61 of 65 patients were analyzed. The levels of NE, E, Cor, and Glu were blunt by TAP block during perioperative period. The levels of IL-6 and IL-10 were significantly lower in TAP group than in control group. TAP block efficiently relieved postoperative acute pain up to 12 h postoperatively with more stable perioperative hemodynamics compared with control group.
Conclusions: Subcostal TAP block blunts perioperative stress response and provides efficient analgesia, with good hemodynamic stability and minimal adverse effects.
Trial registration
The trial was registered prior to patient enrollment at clinicaltrials.gov (NCT03035916, principal investigator: Guoqing Zhao, Ruizhu Liu, Kai Li, date of registration: 01/27/2017).
Intervention trial for prevention and management of multirisk events among people living in geriatric facilities
Authors: Ikeda-Sonoda Shino , Okochi Jiro , Ichihara Nao , Miyata Hiroaki 
Published: August 2019

Abstract
Background: Undesirable risk events, such as falls, aspiration pneumonia and pressure ulcers, are associated with functional decline and cause low quality of life among the elderly. This study analyzed and compared the frequency of major risk events and the effect of standard risk management on their prevention.
Methods: Subjects: This study recruited elderly persons with disabilities using Japanese geriatric intermediate care facilities (GICFs); these individuals provided written informed consent. Intervention: A standardized intervention process of risk management was in place in half of the facilities. The other half provided conventional risk-prevention models.
Outcome variable: The six-month preadmission incidence and three-month postadmission incidence of undesirable events, including falls, aspiration pneumonia, pressure ulcers, dehydration, and fever, were collected.
Analysis: The effect of multidisciplinary care management on the reduction of undesirable events was analyzed.
Results: Overall, 862 elderly persons from 132 facilities using geriatric intermediate care facilities in Japan participated in this study. Falls (35.2%), fever (21.9%), bone fractures (18.2%), and pressure ulcers (12.1%) were frequent undesirable events. There was no reduction in postadmission incidence in the intervention group in any of the patients regardless of the previous incidence. The intervention reduced the occurrence of postadmission pressure ulcers among patients with a previous incidence (odds ratio: 0.34). There were no reductions in falls, fever, or dehydration.
Conclusions: The effect of standardized risk-management implementation is limited to pressure ulcers. The improvement of risk-management processes is needed to understand their limitations in long-term care facilities.
Real-time ultrasound guided spinal anesthesia versus conventional technique for orthopedic knee surgery: a randomized controlled trial
Authors: Amin Shereen M , Mohamed Dina Zakaria , Fouad Ahmed Zaghloul , Mohamed Sohib 
Published: August 2019

Abstract
Background: Ultrasound imaging skills are valuable for enhancing the safety of different puncture techniques supported with the fact that the developments in imaging quality have significantly improved our understanding of spinal sonoanatomy. Today, ultrasound imaging has been used to assist or guide central neuroaxial blocks, however, the data about the use of real time guided ultrasound neuroaxial blocks are scanty. The study aimed to identify the value of using the real time ultrasound guidance in applying spinal anaesthesia when compared with the conventional landmark guided approach, regarding the efficiency of the anesthetic technique and incidence of associated common complications. Methods: This randomized controlled trial included 178 patients scheduled for elective Knee orthopedic surgeries under spinal anesthesia in El Kasr Al-Aini Hospital, Cairo University were enrolled in the study. Patients were randomly assigned into conventional group in which 89 patients received landmark guided paramedian spinal anesthesia and ultrasound group in which 89 patients received real time ultrasound guided paramedian spinal anesthesia. Results: The mean numbers of puncture attempts, levels and needle redirections between the conventional group and ultrasound group were 1.61±0.83 vs. 1.12±0.36 (p=0.013), 1.15±0.36 vs. 1.06±0.25 (p=0.018) and 2.68±2.75 vs. 1.94±1.93 (p=0.021) respectively. Ultrasound guided group of patients showed significant lower incidence of bloody puncture and paraesthesia after engaging the needle through the dura. Conclusion: Real time ultrasound guiding improved the ease of introducing spinal anesthesia, reduced the number of puncture attempts, number of puncture levels, number of needle redirections, and incidence of complications.
Reduced glomerular filtration rate and prior cardiovascular event entail similar risk for coronary atherosclerotic burden
Authors: Piscitelli Pamela Angela , Mangiacotti Antonio , Marchese Nicola , Greco Eulalia Valentina , D'Errico Maria Maddalena , Massa Valentina , Mirijello Antonio , Palena Antonio Pio , Vendemiale Gianluigi , Russo Aldo , Vigna Carlo , Pontremoli Roberto , Cosmo Salvatore De 
Published: August 2019

Abstract
Background: Prior cardiovascular event and kidney dysfunction are both strong risk factor for coronary artery disease. Aim of this study is to assess coronary atherosclerotic burden in a large population of patients undergoing coronary angiography, according to the prior cardiovascular event or chronic kidney disease.
Methods: We evaluated 700 consecutive patients who underwent CA. Serum creatinine to estimate glomerular filtration rate (eGFR) was measured. Clinically significant CAD was defined by the presence of a coronary lesion resulting in a luminal stenosis >50%. For the purpose of the study, the whole population was divided into 4 subgroups according to the presence/absence of eGFR <60 ml/min/1.73 m2 or prior cardiovascular event: eGFR≥60/no event (Group A), eGFR≥60/yes event (Group B), eGFR<60/no event (Group C), eGFR<60/yes event (Group D).
Results: As expected, patients in group D had the worst clinical and biochemical profile. These patients also showed the highest values of ACR (p<0.001) and the lowest values of eGFR (p<0.01). One-hundred-ninety-six patients had three vessel disease. Considering group A as reference, the risk of having three-vessel disease was increased in group B (OR= 2.09; 95% CI 1.37-3.19), in group C, (OR= 1.80; 95% CI 1.04-3.14) and finally in group D (OR= 3.35; 95% CI 2.01-5.58). The risk carried by group C was not significantly different from that carried by Group B: OR= 0.86; 95% CI 0.5-1.5.
Conclusions: In our study low eGFR seems to have the same excess risk of prior CV event.
Educación: ¿prioridad o formalismo de la integración andina?
Authors: Pardo Liliana Liz 
Published: August 2019

El panorama actual suramericano y mundial, plantea múltiples desafíos políticos, económicos y sociales a los procesos de integración, claramente representados en la coyuntura por la que atraviesan los países de la subregión andina y concretamente la Comunidad Andina (CAN). Con la salida de Venezuela, la negociación de los TLC con Estados Unidos por parte de Perú y Colombia, la inestabilidad financiera y los altos índices de pobreza, inequidad y exclusión; resulta evidente la crisis de la comunidad. Y es precisamente en este contexto, que la educación como eje fundamental de la construcción de una identidad andina, se convierte en un espacio propicio para generar cambios de fondo en los términos y lineamientos bajo los cuales se ha fundado esta iniciativa desde ya hace varios lustros de nuestra historia. De allí, que estudiar la orientación de los programas educativos e identificar su posición frente a las temáticas de la integración resulte útil para nuestro objetivo. Este artículo se constituye como un documento de reflexión sobre la relevancia de la educación en la consolidación de los bloques subregionales de integración, como la Comunidad Andina.
Justicia constitucional y dispositivos ideológicos: óptimo paretiano, imposibilidad y decisión en la jurisdicción constitucional
Authors: Corredor Cabrales Edison Ariel 
Published: August 2019

El que cualquier decisión jurisdiccional en la órbita de la justicia constitucional esté salpicada de al menos un componente ideológico encubierto por el tópico de la neutralidad judicial es una realidad que casi cualquier jurista admite. Sin embargo, no hay mayores estudios académicos de ello que los realizados por los Critical Legal Studies (CLS). El presente ensayo aborda esta problemática valiéndose de la teoría de la elección pública de la ciencia económica (y de algunos de sus teoremas) para mostrar: a) que los medios ordinarios de decisión e interpretación constitucional no pueden satisfacer el criterio Pareto-superior, y b) que de desconocerse este criterio no pueden satisfacerse simultáneamente los principios (jurídico-constitucionales) de eficiencia, neutralidad y unanimidad, ni aún en el caso de la ponderación. Ya que sin incurrir en valoraciones, en alguna forma de ideología en particular sobre la justicia, no es posible evitar el dilema, como ha demostrado Sen, entre o ser liberal (respetar ciertos de los derechos) o paretiano (asegurar la eficiencia). El siguiente artículo de reflexión es una ampliación de un texto originalmente presentado como ponencia en el marco del Congreso Internacional de Filosofía del Derecho, Argumentación e Interpretación Jurídica, celebrado en la Universidad Libre de Bogotá D.C., los días 25, 26 y 27 de marzo de 2009.
Whose water? Whose profits? The role of informal water markets in groundwater depletion in peri-urban Hyderabad
Authors: Vij Sumit , John Anshika , Barua Anamika 
Published: August 2019

Abstract
Urbanising cities of India are engulfing the peri-urban land and water resources. Informal water sellers, who transfer water from peri-urban to urban areas, meet the growing water demand in Hyderabad, one of the fastest growing cities in India. This article qualitatively explores how informal water tankers are changing the flows of water, posing challenges to water access for peri-urban residents. We conclude that apart from the state's infrastructural and capacity challenges to provide piped water, power interplay between actors is responsible for the mushrooming of informal water markets. The transfer of water has contributed to groundwater depletion as well as to the water insecurity of peri-urban residents.
Inmigración y discriminación: Hacia un trabajo de aplicación conceptual de la noción weberiana de sentido
Authors: Arriaga Martínez Rafael 
Published: August 2019

Discutimos acerca de la utilidad heurística de la noción weberiana de sentido para explicar la percepción que se tiene en Estados Unidos de los inmigrantes y los indocumentados en particular. Cuestionamos la regla metodológica de que para comprender el sentido de esas percepciones hay que pasar por la noción de estructura y la teoría de la socialización, como lo plantea Jorge Bustamante. Sostenemos que la noción de sentido pone en juego la concepción de un individuo motivado por razones para percibir de X y Y manera a los inmigrantes y que esas razones lejos de ser justificaciones tienen un fundamento real, objetivo. Avanzamos un bosquejo comprensivo de la Ley SB1070 tratando de elucidar algunas de las razones por las que los actores involucrados la aprueban o la desaprueban.
Kaempferol as a Potential PAK4 Inhibitor in Triple Negative Breast Cancer: Extra Precision Glide Docking and Free Energy Calculation
Authors: Arowosegbe Michael A. , Amusan Oluwamuyiwa T. , Adeola Segun A. , Adu Oluwatosin B. , Akinola Israel A. , Ogungbe Bimpe F. , Omotuyi Olaposi I. , Saibu Gbemisola M. , Ogunleye Adewale J. , Kanmodi Ramon I. , Lugbe Nekabari E. , Ogunmola Oluwafemi J. , Ajayi Damilola C. , Ogun Sedoten O. , Oyende Faith O. , Bello Ahmed O. , Ishola Peter G. , Obasieke Patrick E. 
Published: August 2019

Background:
P-21 activating kinase 4 (PAK4) is implicated in poor prognosis of many human
tumors, particularly in Triple Negative Breast Cancer (TNBC) progression. Studies have revealed the crucial
role of PAK4 in cell proliferation, anchorage-independent growth and cell migration among other
hallmarks of cancer. Thus, PAK4 is an attractive target for anti-TNBC drug design and development. In
our research, we used in silico methods to investigate the inhibitory potentials of kaempferol against
PAK4 as compared with co-crystallized 4T6 and a standard PAK4 inhibitor-KPT-9274. The ligands were
docked into the ATP-binding site of the target enzyme and post-docking validations were calculated.

Results:
In the molecular docking results, kaempferol had higher affinity than the standard KPT-9274.
However, the SP and XP docking scores for the co-crystallized 4T6 were the highest. The analyses of the
docking showed a favorable interaction between kaempferol and the catalytic-important aminoacyl residues,
especially GLU396, LEU398 and ASP458 in the ATP-binding site of PAK4 when compared with
what was obtained in the 4T6-PAK4 complex. Molecular mechanics based MM-GBSA was used to validate
docking results. The free energy calculations revealed that kaempferol may have a favorable biological
activity. Furthermore, the druggability of each ligand was assessed using the QikProp module and the
SwissADME online tool. Kaempferol possessed a propitious drug-like property when compared to the
standard ligands.

Conclusions:
We, therefore, put forward a logical argument that kaempferol can be further evaluated as a
potential PAK4 inhibitor in TNBC.