bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reading “Canadian” management in context: development of English and French education
Authors: Arseneault Rene , Deal Nicholous M. , Mills Albert J. 
Published: February 2019

PurposeThe purpose of this paper is to explore the pluralist contours of Canadian management “knowledge” using the discourse “official” bilingualism – the English and French languages – to understand the impact of socio-historical-political differences on the development of management knowledge production.Design/methodology/approachDrawing upon an archival collection of management textbooks as historical data, the authors critically explore and analyze the development of Canadian “schools” and management theory. Using narrative analysis and critical hermeneutics, the paper considers the socio-historical-political context of the various “Canadian” scholars that sought to establish a unique business academy distinct but paradoxically akin to the management schools in the USA.FindingsMirroring the struggle of Francophones in a dominant English imperative, French management textbooks appeared decades later than English titles. When French texts began to disseminate, it remained in the shadows of American management ideologies.Research limitations/implicationsAs only Canadian organizational behavior texts published within the previous 50 years were used as data in this study, it may be incautious to draw broader conclusions. The empirical element of this research relied upon convenience sampling of textbooks.Practical implicationsManagement educators weld a considered level of socio-political power that they may or may not knowingly possess, especially in terms of selecting a textbook and other course materials. Regardless of background, management students are somewhat a “tabula rasa;” open to learning new content to make sense of the world. This “open state” places a great deal of responsibility on the professorate in shaping management students’ theoretical understanding of everyday life in organizations. The authors suggest practitioners be reflexive, aware of how textbooks serve as an important vehicle in education that in times past, have promoted or reified mono-cultural agendas.Originality/valueThe research in this paper builds on recent research that considers the role of socio-historical-political context in how management knowledge and theory is performed, as well as contributes to understanding textbooks in how they may shape a pluralist account of Canadian management “knowledge”.
Breaking the Mould? Roy Jenkins’ ‘Radical Centre’ and British Social Democracy in the ‘New Hard Times’
Authors: Diamond Patrick 
Published: February 2019

AbstractSocial democratic politics in Britain requires compelling answers to three animating questions that Roy Jenkins posed in his landmark 1979 Dimbleby lecture. Firstly, how can the British system of democracy be reformed to develop a culture of political participation and pluralism that leads to more equitable economic and social policies? Secondly, how can the centre‐left and left unite to forestall long periods of Tory dominance in electoral politics, thereby avoiding calamities such as the 2016 referendum on EU membership? And, thirdly, how can a flourishing intellectual ecosystem be cultivated on the progressive left that generates radical ideas for economic and social reform, recognising the importance of concerted dialogue between political traditions? This article revisits Jenkins’ 1979 lecture by considering the prospects for ‘breaking the mould’ of British politics in the ‘new hard times’ of Brexit and ‘permanent austerity’.
Government Companies as Regulators
Authors: Daintith Terence 
Published: February 2019

AbstractIn 2016 the government established a new sectoral regulator, with power to grant and withdraw licences, set performance standards, and impose sanctions, not as a statutory authority but in the form of a company wholly owned by the Secretary of State: the Oil and Gas Authority. This article critically examines this and other uses in the UK of government‐owned or ‐ controlled companies to discharge public regulatory functions, against the background of current government practice regarding arm's length public bodies in general and government companies in particular. It assesses the acceptability of the company form by reference to criteria of democratic control, independence and accountability of regulatory institutions.
Improved efficacy of ramucirumab plus docetaxel after nivolumab failure in previously treated non‐small cell lung cancer patients
Authors: Shiono Ayako , Kaira Kyoichi , Mouri Atsuto , Yamaguchi Ou , Hashimoto Kosuke , Uchida Takahiro , Miura Yu , Nishihara Fuyumi , Murayama Yoshitake , Kobayashi Kunihiko , Kagamu Hiroshi 
Published: February 2019

BackgroundIt is unclear whether the chemotherapy response improves after exposure to immunotherapy. Antiangiogenic agents have been shown to stimulate the immune system and cause synergistic effects that stimulate tumor shrinkage. We conducted a retrospective study to evaluate improvement of the efficacy of ramucirumab plus docetaxel after the failure of nivolumab as a PD‐1 inhibitor.MethodsFrom February 2016 to December 2017, 152 patients with non‐small cell lung cancer (NSCLC) administered nivolumab in our institution were identified. We reviewed the records of 20 NSCLC patients administered ramucirumab plus docetaxel after nivolumab failure. The overall response rate (ORR), progression‐free survival (PFS), and overall survival (OS) were investigated. Pegylated granulocyte colony‐stimulating factor was prophylactically administered to 18 patients (90%) after the administration of ramucirumab plus docetaxel.ResultsThe median age of the patients was 70 (range: 55–77) years. Twelve patients were male and eight were female. The histology was adenocarcinoma in 16 patients, squamous cell carcinoma in three, and other in one. The ORR of ramucirumab plus docetaxel was 60%, and the PFS and OS were 169 and 343 days, respectively. Among the 20 patients, 12 achieved a partial response, giving an ORR of 60.0%. Six patients had stable disease and two had progressive disease. The disease control rate was 90%. Gastrointestinal adverse events were frequently observed in 19 patients.ConclusionsRamucirumab plus docetaxel achieved a higher response rate when administered immediately after nivolumab failure compared to regimens without prior nivolumab administration.
Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models
Authors: Trujillo‐Estrada Laura , Nguyen Cassidy , da Cunha Celia , Cai Lena , Forner Stefania , Martini Alessandra C. , Ager Rahasson R. , Prieto Gilberto Aleph , Cotman Carl W. , Baglietto‐Vargas David , LaFerla Frank M. 
Published: February 2019

AbstractDiabetes mellitus (DM) is one of the most devastating diseases that currently affects the aging population. Recent evidence indicates that DM is a risk factor for many brain disorders, due to its direct effects on cognition. New findings have shown that the microtubule‐associated protein tau is pathologically processed in DM; however, it remains unknown whether pathological tau modifications play a central role in the cognitive deficits associated with DM. To address this question, we used a gain‐of‐function and loss‐of‐function approach to modulate tau levels in type 1 diabetes (T1DM) and type 2 diabetes (T2DM) mouse models. Our study demonstrates that tau differentially contributes to cognitive and synaptic deficits induced by DM. On one hand, overexpressing wild‐type human tau further exacerbates cognitive and synaptic impairments induced by T1DM, as human tau mice treated under T1DM conditions show robust deficits in learning and memory processes. On the other hand, neither a reduction nor increase in tau levels affects cognition in T2DM mice. Together, these results shine new light onto the different molecular mechanisms that underlie the cognitive and synaptic impairments associated with T1DM and T2DM.
HDAC superfamily promoters acetylation is differentially regulated by modafinil and methamphetamine in the mouse medial prefrontal cortex
Authors: González Betina , Bernardi Alejandra , Torres Oscar V. , Jayanthi Subramaniam , Gomez Natalia , Sosa Máximo H. , García‐Rill Edgar , Urbano Francisco J. , Cadet Jean‐Lud , Bisagno Verónica 
Published: February 2019

AbstractDysregulation of histone deacetylases (HDAC) has been proposed as a potential contributor to aberrant transcriptional profiles that can lead to changes in cognitive functions. It is known that METH negatively impacts the prefrontal cortex (PFC) leading to cognitive decline and addiction whereas modafinil enhances cognition and has a low abuse liability. We investigated if modafinil (90 mg/kg) and methamphetmine (METH) (1 mg/kg) may differentially influence the acetylation status of histones 3 and 4 (H3ac and H4ac) at proximal promoters of class I, II, III, and IV HDACs. We found that METH produced broader acetylation effects in comparison with modafinil in the medial PFC. For single dose, METH affected H4ac by increasing its acetylation at class I Hdac1 and class IIb Hdac10, decreasing it at class IIa Hdac4 and Hdac5. Modafinil increased H3ac and decreased H4ac of Hdac7. For mRNA, single‐dose METH increased Hdac4 and modafinil increased Hdac7 expression. For repeated treatments (4 d after daily injections over 7 d), we found specific effects only for METH. We found that METH increased H4ac in class IIa Hdac4 and Hdac5 and decreased H3/H4ac at class I Hdac1, Hdac2, and Hdac8. At the mRNA level, repeated METH increased Hdac4 and decreased Hdac2. Class III and IV HDACs were only responsive to repeated treatments, where METH affected the H3/H4ac status of Sirt2, Sirt3, Sirt7, and Hdac11. Our results suggest that HDAC targets linked to the effects of modafinil and METH may be related to the cognitive‐enhancing vs cognitive‐impairing effects of these psychostimulants.
Single versus multi‐drug antimicrobial surgical infection prophylaxis for left ventricular assist devices: A systematic review and meta‐analysis
Authors: Patel Sinal , Choi Jae Hwan , Moncho Escrivá Ester , Rizvi Syed Saif Abbas , Maynes Elizabeth J. , Samuels Louis E. , Luc Jessica G. Y. , Morris Rohinton J. , Massey Howard T. , Tchantchaleishvili Vakhtang , Aburjania Nana 
Published: February 2019

AbstractInfection remains the Achilles heel of left ventricular assist device (LVAD) therapy. However, an optimal antimicrobial surgical infection prophylaxis (SIP) regimen has not been established. This study evaluated the efficacy of a single‐drug SIP compared to a multi‐drug SIP on clinical outcomes in patients undergoing continuous‐flow LVAD (CF‐LVAD) and pulsatile LVAD (P‐LVAD) implantation. An electronic search was performed to identify studies in the English literature on SIP regimens in patients undergoing LVAD implantation. Identified articles were assessed for inclusion and exclusion criteria. Fourteen articles with 1,311 (CF‐LVAD: 888; P‐LVAD: 423) patients were analyzed. Overall, 501 (38.0%) patients received single‐drug SIP, whereas 810 (62.0%) received multi‐drug SIP. Time to infection was comparable between groups. There was no significant difference in overall incidence of LVAD‐specific infections [single‐drug: 18.7% vs. multi‐drug: 24.8%, P = 0.49] including driveline infections [single‐drug: 14.1% vs. multi‐drug: 20.8%, P = 0.37]. Compared to single‐drug SIP, patients who received multi‐drug SIP had a significantly lower survival rate [single‐drug: 90.0% vs. multi‐drug: 76.0%, P = 0.01] and infection‐free survival rate [single‐drug: 88.4% vs. multi‐drug: 77.3%, P = 0.04] at 90 days. However, there were no significant differences in 1‐year survival and 1‐year infection‐free survival between groups. No survival differences were observed in the CF‐LVAD subset as well. This study demonstrated no additional advantage of a multi‐drug compared to a single‐drug regimen for SIP. Although there was a modest advantage in early survival among CF‐LVAD and P‐LVAD patients who received single‐drug SIP, there were no significant differences in the 1‐year survival and 1‐year infection‐free survival.
Evaluation of selective laser trabeculoplasty as an intraocular pressure lowering option
Authors: Belitsky Yuri , Škiljić Dragana , Zetterberg Madeleine , Kalaboukhova Lada 
Published: February 2019

AbstractPurposeSelective laser trabeculoplasty (SLT) is one of the many treatment options for lowering intraocular pressure (IOP) in patients with glaucoma. This study aimed to evaluate the effect of SLT.MethodsData were collected from medical records of 289 patients who underwent SLT treatment (180° of trabecular meshwork) during 2014 and 2015 at the Department of Ophthalmology, Sahlgrenska University Hospital, Mölndal, Sweden. Baseline characteristics and information from a follow‐up within 100 days were also recorded. The study analysed different subtypes of glaucoma with regard to SLT, with a particular focus on exfoliative glaucoma, a common subtype in Sweden. Successful treatment was defined as an IOP lowering effect of >20% with no further changes in treatment. The impact of surgeon's experience on treatment outcome was also analysed.ResultsBoth patients with exfoliative glaucoma and those with primary open‐angle glaucoma showed a reduction in mean IOP; no significant difference was found between these two subtypes before treatment or at the first follow‐up. The success rate at follow‐up (within 100 days) was 52%. There was a significant difference in outcome between surgeons with different levels of experience, but this difference could likely be explained by differences in treatment strategies and total energy used.ConclusionFor many patients with glaucoma, SLT was an effective treatment option for lowering IOP. It was also effective for several glaucoma subtypes. However, not all patients had a significant reduction in IOP after treatment with SLT, and some may require additional treatment.
Polymorphisms in the NFkB, TNF‐alpha, IL‐1beta, and IL‐18 pathways are associated with response to anti‐TNF therapy in Danish patients with inflammatory bowel disease
Authors: Bank Steffen , Julsgaard Mette , Abed Osama Karim , Burisch Johan , Broder Brodersen Jacob , Pedersen Natalia Konstantinovich , Gouliaev Anja , Ajan Rullah , Nytoft Rasmussen Ditlev , Honore Grauslund Camilla , Roug Stine , Galsgaard Julie , Sprogøe Høyer Finsen David , Lindby Karoline ,   The Danish IBD Genetics Working Group, Sørensen Jeanette , Larsen Lone , Rohr Andersen Malene , Brandslund Ivan , Thomassen Mads , Green Anders , Bo Bojesen Anders , Bek Sørensen Signe , Vogel Ulla , Andersen Vibeke 
Published: February 2019

SummaryBackgroundAnti‐tumor necrosis factor‐α (TNF‐α) is used for the treatment of severe cases of IBD, including Crohn's disease (CD) and ulcerative colitis (UC). However, one‐third of the patients do not respond to the treatment. We have previously investigated whether single nucleotide polymorphisms (SNPs) in genes involved in inflammation were associated with response to anti‐TNF therapy among patients with CD or UC.AimA new cohort of patients was established for replication of the previous findings and to identify new SNPs associated with anti‐TNF response.MethodsFifty‐three SNPs assessed previously in cohort 1 (482 CD and 256 UC patients) were genotyped in cohort 2 (587 CD and 458 UC patients). The results were analysed using logistic regression (adjusted for age and gender).ResultsTen SNPs were associated with anti‐TNF response either among patients with CD (TNFRSF1A(rs4149570) (OR: 1.92, 95% CI: 1.02‐3.60, P = 0.04), IL18(rs187238) (OR: 1.35, 95% CI: 1.00‐1.82, P = 0.05), and JAK2(rs12343867) (OR: 1.35, 95% CI: 1.02‐1.78, P = 0.03)), UC (TLR2(rs11938228) (OR: 0.55, 95% CI: 0.33‐0.92, P = 0.02), TLR4(rs5030728) (OR: 2.23, 95% CI: 1.24‐4.01, P = 0.01) and (rs1554973) (OR: 0.49, 95% CI: 0.27‐0.90, P = 0.02), NFKBIA(rs696) (OR: 1.45, 95% CI: 1.06‐2.00, P = 0.02), and NLRP3(rs4612666) (OR: 0.63, 95% CI: 0.44‐0.91, P = 0.01)) or in the combined cohort of patient with CD and UC (IBD) (TLR4(rs5030728) (OR: 1.46, 95% CI: 1.01‐2.11, P = 0.04) and (rs1554973)(OR: 0.80, 95% CI: 0.65‐0.98, P = 0.03), NFKBIA(rs696) (OR: 1.25, 95% CI: 1.01‐1.54, P = 0.04), NLRP3(rs4612666) (OR: 0.73, 95% CI: 0.57‐0.95, P = 0.02), IL1RN(rs4251961) (OR: 0.81, 95% CI: 0.66‐1.00, P = 0.05), IL18(rs1946518) (OR: 1.24, 95% CI: 1.01‐1.53, P = 0.04), and JAK2(rs12343867) (OR: 1.24, 95% CI: 1.01‐1.53, P = 0.04)).ConclusionsThe results support that polymorphisms in genes involved in the regulation of the NFκB pathway (TLR2, TLR4, and NFKBIA), the TNF‐α signalling pathway (TNFRSF1A), and other cytokine pathways (NLRP3, IL1RN, IL18, and JAK2) were associated with response to anti‐TNF therapy. Our multi‐SNP model predicted response rate of more than 82% (in 9% of the CD patients) and 75% (in 15% of the UC patients), compared to 71% and 64% in all CD and UC patients, respectively. More studies are warranted to predict response for use in the clinic.
Cetuximab pharmacokinetic/pharmacodynamics relationships in advanced head and neck carcinoma patients
Authors: Le Louedec Félicien , Alix‐Panabières Catherine , Lafont Thierry , Allal Ben C. , Garrel Renaud , Digue Laurence , Guigay Joël , Cupissol Didier , Delord Jean‐Pierre , Lallemant Benjamin , Alfonsi Marc , Aubry Karine , Mazel Martine , Becher François , Perriard Françoise , Chatelut Etienne , Thomas Fabienne 
Published: February 2019

AimsCetuximab associated with cisplatin and 5‐fluorouracil is used to treat patients with inoperable or metastatic head and neck squamous cell carcinomas (HNSCC) up until disease progression or unacceptable toxicities. To date, no biomarkers of efficacy are available to select patients who will benefit from treatment.MethodsAn ancillary pharmacokinetics (PK) exploration was performed in the context of a prospective study investigating circulating‐tumour cells vs progression‐free survival (PFS). Cetuximab plasma concentrations were analysed according to a population PK model. Individual exposure parameters were confronted with soluble epidermal growth factor receptor (sEGFR) concentrations, tumour response and PFS.ResultsPK data (28 patients, 203 observations) were best described by a two‐compartment model with linear elimination. Performance status (PS) significantly correlated to both cetuximab clearance and central volume of distribution with both parameters increasing by 33.3% (95% CI 1–65.6) for each 1‐point increase of PS compared to PS = 0. Univariate analysis showed that patients with higher trough cetuximab concentrations at Day 7 (Cmin,D7) had better tumour response (P = 0.03) and longer PFS (P = 0.035). However, multivariate analysis revealed that only PS and tumour size at baseline remained significantly associated with PFS. Levels of sEGFR increased during cetuximab treatment but were not associated with PFS in the multivariate analysis.ConclusionsOur study prospectively indicates that PS is likely a confounding factor in the relationship between cetuximab PK and PFS, patients with a poor PS having lower cetuximab plasma exposure and lower PFS.
Impact of continuous electronic fetal monitoring on birth outcomes in low‐risk pregnancies
Authors: Heelan‐Fancher Lisa , Shi Ling , Zhang Yuqing , Cai Yurun , Nawai Ampicha , Leveille Suzanne 
Published: February 2019

AbstractBackgroundContinuous electronic fetal monitoring (CEFM) is a standard of hospital care during the intrapartum period. We investigated its use on childbirth outcomes in low‐risk pregnancies, and examined whether outcomes differed by gestational age within a term pregnancy.MethodsA retrospective secondary data analysis using birth registry data from two diverse northeastern US states from 1992 to 2014. Chi‐square test and the Fisher exact tests were used to examine associations between CEFM and childbirth outcomes. Multivariable Poisson regression models were used to estimate risk ratios of childbirth outcomes related to CEFM use, adjusting for potential confounders.ResultsUse of CEFM was independently associated with a 10% (State 1) and 40% (State 2) increased risk for primary cesarean delivery and an increased risk for assisted vaginal births (14% and 24%, respectively) after adjustment for confounders. CEFM use was not associated with reduced risk for infant mortality (neonatal mortality, 0‐27 days, and post‐neonatal mortality, 28‐364 days) in term births (37‐41 weeks’ gestation). After stratifying term pregnancies into early term, full term, and late term, use of CEFM was associated with reduced risk for neonatal mortality in early‐term births (37 0/7 weeks’ to 38 6/7 weeks’ gestation) in State 2 (RR 0.44 [95% CI 0.21‐0.92]), but not in State 1. There was no association between CEFM use and infant mortality (neonatal and post‐neonatal) in full‐term or late‐term births.ConclusionsThe study results do not support universal use of CEFM in pregnancies that are low‐risk and at term.
Rational design and in vitro characterization of novel dental implant and abutment surfaces for balancing clinical and biological needs
Authors: Milleret Vincent , Lienemann Philipp S. , Gasser Angelines , Bauer Sebastian , Ehrbar Martin , Wennerberg Ann 
Published: February 2019

AbstractBackgroundLong‐term success and patient satisfaction of dental implant systems can only be achieved by fulfilling clinical as well as biological needs related to maintenance, aesthetics, soft tissue sealing, and osseointegration, among others. Surface properties largely contribute to the biological and clinical performance of implants and abutments.PurposeTo decipher the clinical and biological needs in implant dentistry. To address identified needs, next‐generation dental implant and abutment surfaces are designed and characterized in vitro.Materials and MethodsNovel implant and abutment surface designs were produced and characterized using surface chemical analysis, surface topography analysis, scanning electron microscopy, contact‐angle measurements, and cell‐culture experiments.ResultsThe novel anodized implant surface was gradually anodized, increasing the surface roughness, surface enlargement, and oxide‐layer thickness from platform to apex. The surface was phosphorus enriched, nonporous, and nanostructured at the collar, and showed micropores elsewhere. The novel anodized abutment surface was smooth, nanostructured, nonporous, and yellow. Pristine surfaces with high density of hydroxyl‐groups were protected during storage using a removable cell‐friendly layer that allowed dry packaging.ConclusionsA novel anodized implant system was developed with surface chemistry, topography, nanostructure, color, and surface energy designed to balance the clinical and biological needs at every tissue level.