bluuebunny/crossref_metadata_2025_split huggingface dataset:
First trimester physiological development of the fetal foot position using three‐dimensional ultrasound in virtual reality
Authors: Bogers Hein , Rifouna Maria S. , Cohen‐Overbeek Titia E. , Koning Anton H. J. , Willemsen Sten P. , van der Spek Peter J. , Steegers‐Theunissen Régine P. M. , Exalto Niek , Steegers Eric A. P. 
Published: November 2018

AbstractAimIn anatomic studies of the embryo, it has been established that during the development of the lower limb, several changes in foot position can be observed defined as a temporary ‘physiological clubfoot’. The aim of this study was to develop and test a measurement tool for objective documentation of the first trimester foot position in vivo and made an attempt to create a chart for first trimester foot position.MethodsWe developed a virtual orthopedic protractor for measuring foot positioning using three‐dimensional virtual reality visualization. Three‐dimensional ultrasound volumes of 112 pregnancies of women examined during the first trimester were studied in a BARCO I‐Space. The frontal angle (plantar flexion) and the lateral angle (adduction) between the leg and foot were measured from 8 until 13 weeks gestational age.ResultsWe observed that the frontal angle steadily decreases, whereas the lateral angle first increases, resulting in transient physiological clubfeet position at 10‐ to 11‐week gestation, followed by a decrease to a normal foot position.ConclusionA transient clubfoot position is present during the normal development of the lower limbs, and it has been measured in vivo for the first time. This study emphasizes that a diagnosis of congenital clubfoot should not be made in the first trimester of pregnancy.
Pathotypic and molecular evolution of contemporary population of Puccinia striiformis f. sp. tritici in Egypt during 2016–2018
Authors: Draz Ibrahim Sobhy 
Published: November 2018

AbstractThe contemporary races of Puccinia striiformis f. sp. tritici (Pst) in Egypt during 2016–2018 were differentiated based on virulence and molecular patterns. Virulence patterns based on the reaction of the 17 World/European differential sets carrying stripe rust resistance genes (Yr genes) resulted in ten races including four new (first recorded in Egypt) and six old (previously recorded in Egypt). The new races were identified as 64E0 (virulence [V] Yr4, Su), 0E16 (V Yr8, 19), 66E0 (V Yr4, 7, 22, 23, Su) and 4E130 (V Yr2, 6, 7, 25, HVII), while the old were 0E0 (avirulence), 2E0 (V Yr7, 22, 23), 2E16 (V Yr7, 8, 19, 22, 23), 4E0 (V Yr2, 6), 6E4 (V Yr2, 6, 7, 22, 23, 25) and 70E4 (V Yr2, 4, 6, 7, 22, 23, 25, Su). Cluster analysis differentiated Pst races based on virulence frequency to Yr genes. Simple sequence repeat (SSR) markers were used to detect the molecular polymorphism of the Pst races. Clustering separated the old and new races into two groups, indicating their common ancestry since the new races were very distinct from the old races. Although clustering based on virulence revealed some evolutionary patterns, where the new races 64E0 and 66E0 may have probably evolved from the old races (2E16, 2E0, 6E4, 70E4) and the new race 4E130 may be evolved from the joint race 4E0. However, clustering based on molecular patterns indicated that the new races appear to be genetically distinct and may represent an exotic introduction rather than a mutation in isolates of the old races. A weak association between virulence and molecular patterns revealed that they are independent of each other. The SSR markers did not correspond to the virulences in the pathogen. Further studies on the potential virulence genes of the detected Pst virulences are needed.
The chemical composition, antifungal, antioxidant and antimutagenicity properties of bioactive compounds from fungal endophytes associated with Thai orchids
Authors: Bungtongdee Nattawadee , Sopalun Kathawut , Laosripaiboon Wanpen , Iamtham Siriluck 
Published: November 2018

AbstractSome plant‐derived bioactive compounds produced by fungal endophytes have been proven to have antimicrobial and antioxidant activities. In this study, endophytic fungi were isolated from 20 orchid samples collected in northern Thailand from 12 genera of orchids. In total, 97 isolates were isolated from the leaves (44.3%), stems (40.2%) and flowers (15.5%) of the orchid samples. The antifungal activity was investigated of the endophytic isolates against the plant pathogenic fungi. The results showed that 13 endophytic isolates provided antifungal activities against Fusarium sp., Colletotrichum sp. and Curvularia sp. The endophyte CK F05‐5, which was isolated from the flower part of Dendrobium lindleyi, was chosen for further testing because it the highest level of antifungal activity against Fusarium sp. The isolate CK F05‐5 was identified as Fusarium oxysporum on the basis of its ITS sequences of 5.8 s rRNA, and phytochemical analysis revealed the presence of coumarins. The ethyl acetate extract of CK F05‐5 was examined for its total phenolic content and antioxidant activity using Folin–Ciocalteu's reagent and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging assay, respectively. The phenolic content was 160.51 mg of GAE/g of extract, and the free radical scavenging activity was 89.61 µg/ml at the half maximal inhibitory concentration (IC50). The antimutagenic potential of the ethyl acetate extract of CK F05‐5 against Trp‐P‐1 mutagenic substances was determined using the Ames test which revealed that the extract of CK F05‐5 at 10 mg/plate had the highest antimutagenic activity against Trp‐P‐1 (51.2%) and 39.6% for strains TA98 and TA100, respectively. The active compounds present in the acetate extract of CK F05‐5 were examined using GC‐MS analysis, which displayed the presence of gibepyrone A, pyrrolo [1, 2‐a] pyrazine‐1, 4‐dione, hexahydro‐3‐(2‐methylpropyl) and indoleacetic acid as major components. Based on the results, this endophytic fungus contains various bioactive components that have various biological activities. This useful information could help in producing potentially valuable and novel pharmaceutical products.
Healing differences in narrow diameter implants submitted to immediate and conventional loading in mandibular overdentures: A randomized clinical trial
Authors: Bielemann Amália Machado , Marcello‐Machado Raissa Micaella , Schuster Alessandra Julie , Chagas Júnior Otacílio Luiz , Del Bel Cury Altair Antoninha , Faot Fernanda 
Published: November 2018

BackgroundBiological responses to different loading protocols during the bone healing phase in subjects with long time since edentulism, rehabilitated with narrow diameter implants (NDIs) to retain mandibular overdentures (MOs), are still unavailable.ObjectiveThis randomized clinical trial compared the peri‐implant health, implant stability, and concentrations of pro‐ and anti‐inflammatory cytokines in the peri‐implant crevicular fluid (PICF) in mandibular edentulous patients under conventional (CL) and immediate loading (IML) during healing.MethodologyTwenty totally edentulous patients received two NDIs (2.9 × 10 mm, Facility NeoPoros) placed in mandible anterior region and were randomly assigned to two loading protocols: CL (n = 10) and IML (n = 10). The following clinical outcomes were evaluated 1, 2, 4, 8, and 12 weeks after surgery: (a) peri‐implant tissue health (gingival index‐GI, plaque index‐PI, calculus‐presence CP, probing depth‐PD, and bleeding on probing‐BOP); (b) implant stability quotient (ISQ); and (c) IL‐1β, IL‐6, IL‐10, and TNF‐α levels in the PICF analyzed by ELISA.ResultsThe CL group showed significantly higher CP scores at weeks 8 and 12. The IML group showed significantly higher GI from the first week onwards. The IML group presented significantly lower PD at all follow‐up times, and higher BOP rates than CL at week 12. The ISQ values of the CL group were higher than those of the IML group, except at week 4. The IML group released significantly more TNF‐α between weeks 1 and 4 and more IL‐1β during week 4‐12, while releasing less IL‐6 until week 8, mainly at week 2 (−47.6%). The release of IL‐10 was similar for both groups and increased progressively over time. At week 12, the IML group released 45.74% more IL‐10 than the CL group. The survival rates were 95% and 90% for CL and IML, respectively.ConclusionThe IML group presented more favorable PD at all evaluation times; the differences between the other clinical parameters were less systematic. The implant stability and the inflammatory marker concentrations were more stable in the CL group.
Periodontal condition in Japanese coronary heart disease patients: A comparison between coronary and non‐coronary heart diseases
Authors: Aoyama Norio , Kobayashi Naho , Hanatani Tomoya , Ashigaki Norihiko , Yoshida Asuka , Shiheido Yuka , Sato Hiroki , Takamura Chisato , Yoshikawa Shunji , Matsuo Katsuhiko , Izumi Yuichi , Isobe Mitsuaki 
Published: November 2018

ObjectiveThe aim of this clinical trial was to assess the relationship between periodontal bacterial burden and coronary heart disease (CHD) in Japanese population.BackgroundMany epidemiological reports suggest that periodontitis is a risk factor for CHD; however, the influence of each periodontal bacterium and periodontal condition in Japanese CHD patients is unclear.MethodsWe studied 897 patients with cardiovascular diseases in Tokyo Medical and Dental University Hospital from May 2012 to August 2015. The subjects were divided into six groups according to age and the existence of CHD (46‐60 years with CHD (n = 56): Group YC, 61‐70 years with CHD (n = 106): Group MC, over 70 years with CHD (n = 177): Group EC, 46‐60 years without CHD (n = 152): Group YN, 61‐70 years without CHD (n = 216): Group MN, and over 70 years without CHD (n = 190): Group EN).ResultsWe found that the patients in Groups MC and EC had deeper periodontal pocket compared to the patients in Group YN (P < 0.05), although there was no statistical difference of pocket depth between Group YC and Groups MC and EC. Many subjects in Group EC had high anti‐Porphyromonas gingivalis and anti‐Prevotella intermedia antibodies in comparison to Group EN (P < 0.05). The CHD patients generally had worse oral condition than the non‐CHD patients. Elderly with CHD had a higher level of serum anti‐Porphyromonas gingivalis antibody and anti‐Prevotella intermedia antibody than those without CHD.ConclusionIncreased periodontal infection was found in Japanese CHD patients compared to non‐CHD patients.
Longitudinal monitoring of anti‐saliva antibodies as markers of repellent efficacy against Phlebotomus perniciosus and Phlebotomus papatasi in dogs
Authors: Risueño J. , Spitzová T. , Bernal L. J. , Muñoz C. , López M. C. , Thomas M. C. , Infante J. J. , Volf P. , Berriatua E. 
Published: November 2018

AbstractA 2‐year longitudinal study of enzyme‐linked immunosorbent assay (ELISA) antibodies against Phlebotomus perniciosus and Phlebotomus papatasi (Diptera: Psychodidae) sandfly saliva was performed in 32 Beagle dogs treated preventively with an imidacloprid–permethrin topical insecticide in an endemic area in Spain. Dogs were grouped into three sandfly exposure groups according to the time of inclusion in the study. Assays analysed immunoglobulin G (IgG) against salivary gland homogenates (SGH) of both species and recombinant P. papatasi rSP32 and P. perniciosus rSP03B proteins in serum. The dogs were participating in a Leishmania infantum (Kinetoplastida: Trypanosomatidae) vaccine trial and were experimentally infected with the parasite in the second year. No dog acquired natural L. infantum infections during the first year, but most developed anti‐saliva antibodies, and median log‐transformed optical densities (LODs) were seasonal, mimicking those of local sandflies. This indicates that the repellent efficacy of the insecticide used is below 100%. Multi‐level modelling of LODs revealed variability among dogs, autocorrelation and differences according to the salivary antigen and the dog's age. However, dog seroprevalence, estimated using pre‐exposure LODs as cut‐offs, was relatively low. This, and the fact that dogs did not become naturally infected with L. infantum, would support the efficacy and usefulness of this imidacloprid–permethrin topical insecticide in canine leishmaniasis control.
Perspectives on phronesis in professional nursing practice
Authors: Jenkins Karen , Kinsella Elizabeth Anne , DeLuca Sandra 
Published: November 2018

AbstractThe concept of phronesis is venerable and is experiencing a resurgence in contemporary discourses on professional life. Aristotle’s notion of phronesis involves reasoning and action based on ethical ideals oriented towards the human good. For Aristotle, humans possess the desire to do what is best for human flourishing, and to do so according to the application of virtues. Within health care, the pervasiveness of economic agendas, technological approaches and managerialism create conditions in which human relationships and moral reasoning are becoming increasingly de‐valued. This creates a tension for nurses, and nursing leaders, as the desire to do what is morally right is often in conflict with contextual demands. In this paper, Aristotle’s writing on phronesis is examined with a focus on his classic conceptions of eudaimonia, the virtues, deliberation, judgement, and praxis. Building on Aristotle’s work, a number of contemporary views are explored with a focus on what various conceptualizations offer for the discipline of nursing. These expanded conceptions of phronesis include attention to: embodiment in practice; open‐mindedness including the capacity to stay curious and open to recognizing what we do not know; perceptiveness as a disposition towards insight and aesthetic understanding; and reflexivity as an ongoing process of interrogation and inquiry into ourselves and our actions. Drawing on these concepts, we discuss the affordances of phronesis as a morally informed guiding force to attend to modern‐day challenges in nursing practice and nursing leadership.
Bearing witness in nursing practice: More than a moral obligation?
Authors: Djkowich Mikelle , Ceci Christine , Petrovskaya Olga 
Published: November 2018

AbstractIn this paper, we explore the concept of bearing witness in nursing practice. We examine the description of bearing witness in the nursing literature, particularly that offered by William Cody who suggests that bearing witness results in the limited moral obligation of “true presence.” We then turn to Lorraine Code's work on testimony, drawing parallels between the concepts of testimony and bearing witness. Code suggests that receiving testimony results in a responsibility to respond, and that this is an ethico‐political obligation. We discuss these ideas in relation to a Canadian exemplar of witnessing the Truth and Reconciliation Commission of Canada's work to understand and address the historical injustices done to Indigenous peoples in Canada. Here, we focus on the Commission's definition of witnessing and highlight the experience of Shelagh Rogers who served as an honorary witness. As an outcome of our analysis, we suggest that bearing witness in nursing practice is most usefully conceptualized as both a moral and a political obligation. Implications for nursing practice are suggested, including first, the need to critically examine our own understandings of power and privilege in order to authentically bear witness and avoid being complicit in injustice, and second, the concomitant responsibility to take action to challenge injustice once we have borne witness to it.
Growth patterns and overbite depth indicators of long and short faces in Korean adolescents: Revisited through mixed‐effects analysis
Authors: Han Seong Ho , Park Young‐Seok 
Published: November 2018

Structured AbstractObjectiveThe purpose was to evaluate skeletal factors related to the growth of subjects with skeletal open and deep bites based on lateral cephalographs from 9 years of pure longitudinal data using mixed effect analysis.Setting and Sample PopulationFifty‐one children with extreme lower anterior facial height to total anterior facial height (LAFH/TAFH) ratio values at the age of 14 were assigned to either skeletal open bite or skeletal deep bite groups from a total of 223 subjects.Material & MethodsThe palatal plane angle (PPA), mandibular plane angle (MPA), gonial angle (GA), palatomandibular plane angle (PMA), upper gonial angle (UGA), lower gonial angle (LGA), occlusal plane angle (OPA) and overbite depth indicator (ODI) were measured and analysed. Mixed‐effects regression model analysis was used for the interpretation of data with random effects.ResultsMorphological differences were evident from the beginning and became more pronounced with age in MPA, GA, PMA, ODI and LGA. The initial values of all variables were statistically significant. Annual increases with age were statistically significant in GA, OPA, ODI and UGA. The morphological differences in the annual increases in MPA, GA, PMA and UGA were also statistically significant.ConclusionsMorphologically different growth patterns were mainly contributed by lower anterior facial height dimensions. The extent of individual variations mandates judicious decision‐making in clinical situations.
Glycopyrronium tosylate in pediatric primary axillary hyperhidrosis: Post hoc analysis of efficacy and safety findings by age from two phase three randomized controlled trials
Authors: Hebert Adelaide A. , Glaser Dee Anna , Green Lawrence , Werschler William P. , Forsha Douglass W. , Drew Janice , Gopalan Ramanan , Pariser David M. 
Published: November 2018

AbstractObjectivesHyperhidrosis in pediatric patients has been understudied. Post hoc analyses of two phase 3 randomized, vehicle‐controlled, 4‐week trials (ATMOS‐1 [NCT02530281] and ATMOS‐2 [NCT02530294]) were performed to assess efficacy and safety of topical anticholinergic glycopyrronium tosylate (GT) in pediatric patients.MethodsPatients had primary axillary hyperhidrosis ≥ 6 months, average Axillary Sweating Daily Diary (ASDD/ASDD‐Children [ASDD‐C]) Item 2 (sweating severity) score ≥ 4, sweat production ≥ 50 mg/5 min (each axilla), and Hyperhidrosis Disease Severity Scale (HDSS) ≥ 3. Coprimary end points were ≥ 4‐point improvement on ASDD/ASDD‐C Item 2 (a validated patient‐reported outcome) and change in gravimetrically measured sweat production at Week 4. Efficacy and safety data are shown through Week 4 for the pediatric (≥ 9 to ≤ 16 years) vs older (> 16 years) subgroups.ResultsSix hundred and ninety‐seven patients were randomized in ATMOS‐1/ATMOS‐2 (GT, N = 463; vehicle, N = 234); 44 were ≥ 9 to ≤ 16 years (GT, n = 25; vehicle, n = 19). Baseline disease characteristics were generally similar across subgroups. GT‐treated pediatric vs older patients had comparable improvements in ASDD/ASDD‐C Item 2 (sweating severity) responder rate, HDSS responder rate (≥ 2‐grade improvement]), sweat production, and quality of life (mean change from Baseline in Dermatology Life Quality Index [DLQI]/children's DLQI), with greater improvement vs vehicle. Treatment‐emergent adverse events were similar between subgroups, and most were mild, transient, and infrequently led to discontinuation.ConclusionsTopical, once‐daily GT improved disease severity (ASDD/ASDD‐C, HDSS), sweat production, and quality of life (DLQI), with similar findings in children, adults, and the pooled population. GT was well tolerated, and treatment‐emergent adverse events were qualitatively similar between subgroups and consistent with other anticholinergics.
The Evolving State of Gentrification
Authors: Wyly Elvin 
Published: November 2018

AbstractHackworth and Smith’s ‘Changing State of Gentrification’, published in 2001 and focused on New York City, is a definitive landmark. As you read these words, ‘New York City 2001’ might seem distant coordinates in the accelerating time‐space of knowledge production, but it’s not very far when understood in the time horizon of humanity’s urban evolution. Hackworth and Smith’s work helps us rethink today’s theoretical frontiers (especially postcolonial attacks on gentrification theory as a neocolonial imposition on the Global South) as well as long‐forgotten traditions. Ruth Glass’s critique of gentrification in 1964 was already a global, postcolonial challenge to the imperial epistemic violence that consolidated the West – neoliberal doctrines of human competition premised in nineteenth‐century social Darwinism and eugenics. Understanding the changing state of gentrification today requires confronting the planetary politics of urbanised human competition and hijacked theories of human evolution, and deciding what kinds of humans we wish to become.
[Des]velhecer, uma reflexão sensório-cênica sobre a mulher e o envelhecimento
Authors: Fischer Stela , Olivares Leticia 
Published: November 2018

Este texto identifica e analisa a ação cênica [des]velhecer, do coletivo Rubro Obsceno, na cidade de São Paulo. Considerando a análise e cartografia dessa ação – que lança posicionamentos políticos na construção de poéticas cênicas e cujas premissas giram em torno de visibilizar as subjetividades das mulheres a partir de 60 anos –, enfatizamos a importância da reflexão crítica desde o próprio fazer artístico. Para isso, trazemos inspirações dos trabalhos de Tellas, Diéguez e Beauvoir, entre outras. Compartilhamos a experiência de criação enquanto artistas das artes cênicas e, acima de tudo, identificamos os motivos pelos quais ainda se faz necessário promover ativismos feministas.
Palavras-chave: Ativismo feminista, Teatro de mulheres, Ação social.
Víctor Zavala Cataño e seu Teatro Campesino
Authors: Santos Patricia Freitas dos 
Published: November 2018

Este trabalho apresenta uma tradução da peça El Gallo, de Víctor Zavala Cataño, inédita em língua portuguesa. Buscamos, assim, preencher uma lacuna nos estudos teatrais no Brasil, além de pontuar, através de um texto introdutório, a importância de um trabalho intensamente cerceado, visto que o autor se manteve como preso político no Peru até junho de 2017.
Palavras-chave: Teatro político, Víctor Zavala Cataño, El Gallo.
O complexo de Penélope
Authors: Almeida Daniel Manzoni de 
Published: November 2018

Neste conto exponho a história de Eliseu: um jovem de classe média alta, cisgênero, branco, homossexual e profissionalmente reconhecido. Aparentemente, bem-sucedido aos padrões da estrutura da sociedade brasileira. Porém, ainda falta um amor em sua vida. Na busca desse relacionamento, Eliseu é como o mito de Penélope, na Odisseia de Homero, subvertido: em vez de esperar, procura por seu amado construindo no dia as possibilidades de uma relação, mas a destruindo à noite com facilidade o pouco que construiu, sempre na busca de uma felicidade pautada nas normas de uma sociedade heteronormatizada e sem referências claras de amor-gay.
Palavras-chave: Literatura LGBT; Conto LGBT.