bluuebunny/crossref_metadata_2025_split huggingface dataset:
Starting Points: Divergent Trajectories of Labor Market Integration among U.S. Lawful Permanent Residents
Authors: Kreisberg A Nicole 
Published: December 2018

AbstractLegal status is a growing dimension of inequality among immigrants in the U.S. Scholars have suggested that the legal status with which immigrants enter the country stratifies their short- and long-term opportunities for labor market integration. However, much quantitative immigration scholarship modeling the relationship between legal status and labor market integration treats legal status as static. In reality, immigrants change statuses dynamically throughout their lives. This article uses a dynamic conceptualization of legal status, as well as nationally representative data and regression and propensity score weighting techniques, to examine whether five initial legal statuses are associated with divergent labor market trajectories even after those statuses change. I find that initial legal statuses—which I refer to as starting points—are associated with ordered differences in immigrants’ occupational positions immediately after immigrants change status to lawful permanent residence. These differences persist over time. Five years after all immigrants share lawful permanent residence, employment visa holders maintain more prestigious jobs; immigrants with family reunification and diversity status are in the middle; and immigrants with refugee status and undocumented experience have less prestigious jobs. This article demonstrates aggregate, longitudinal patterns of stratification among a nationally representative sample of permanent residents. The findings suggest the importance of modeling legal status as a dynamic rather than static category to reflect the continued influence of legal status starting points on immigrants’ labor market integration.
How UK Scientists Legitimize Religion and Science Through Boundary Work
Authors: Sorrell Katherine , Ecklund Elaine Howard 
Published: December 2018

AbstractResearch on the religious lives of scientists focuses mainly on U.S. scientists. Drawing on 115 interviews with UK biologists and physicists collected between 2011 and 2014, we move beyond to examine how UK scientists understand religion, a context that is seemingly more secular than the United States. Findings show that scientists maintain the legitimacy of science through boundary work with religion, and under certain conditions religion may actually gain legitimacy from these tight boundaries. When religion violates this tight boundary by making claims that conflict with science, particularly in the form of creationist claims, scientists consider religion illegitimate and irrational, engaging in critical boundary work. Yet, when they see religion as adaptable to science, flexible rather than dogmatic, scientists believe religion may be beneficial and engage in more conciliatory boundary work. This article shows how scientists react to religion and use it in ways that protect science’s epistemological and institutional authority.
The effect of precipitation received during gestation on progeny performance in Bos indicus influenced beef cattle
Authors: Beard Joslyn K , Silver Gail A , Scholljegerdes Eric J , Summers Adam F 
Published: December 2018

Abstract
The objective of this retrospective study was to determine the effect of precipitation level during key fetal development periods on beef progeny performance. The hypothesis that was precipitation level during different periods of gestation would program subsequent calves for an environment similar to that experienced in utero resulting in altered growth and reproductive performance. Data were collected on Brangus cows (n = 2,429) over a 46-yr span at the Chihuahuan Desert Rangeland Research Center. Recorded precipitation values were used to calculate average precipitation associated with total gestation (April–March), early gestation, (July–September), and late gestation (December–February). These values were used to classify treatments: low (z value ≤ –1.00), average (z value –0.99 to +0.99), and high (z value ≥ +1.00) for each time period. Calves experiencing high precipitation throughout gestation had heavier body weight (BW) at birth (P = 0.02), weaning (P = 0.05), and adjusted 205-d BW (P = 0.04) than those experiencing low precipitation . Female progeny gestated during low precipitation throughout gestation were more likely to remain (P &lt; 0.0001) in the herd and calve after the age of 8 yr when compared to heifers experiencing high precipitation levels in utero (38% vs. 16% ± 5%, respectively). In addition, a greater percentage (P &lt; 0.0001) of heifers experiencing low precipitation levels during the early gestation period produced a calf within the herd after 8 yr of age. Similarly, calves experiencing low precipitation during those same time points also had a greater number of calves while in production (P &lt; 0.0001) when compared to the average and high precipitation groups. These results indicate that selection of heifers exposed to lower than average precipitation levels in utero may result in increased herd retention and productivity.
Correlation of the tamoxifen use with the increased risk of deep vein thrombosis and pulmonary embolism in elderly women with breast cancer
Authors: Lin Hsien-Feng , Liao Kuan-Fu , Chang Ching-Mei , Lin Cheng-Li , Lai Shih-Wei , Hsu Chung-Y. 
Published: December 2018

Abstract
The association between tamoxifen use and risk of deep vein thrombosis or pulmonary embolism in women with breast cancer has been reported in the Western population. The study aimed to evaluate the association between tamoxifen use and deep vein thrombosis or pulmonary embolism in older women with breast cancer in Taiwan.
We conducted a retrospective case–control study using the database of the Taiwan National Health Insurance Program. A total of 281 women subjects with breast cancer aged ≥65 years with newly diagnosed deep vein thrombosis/or pulmonary embolism from 2000 to 2011 were identified as the cases. Additionally, 907 women subjects with breast cancer aged ≥65 years without deep vein thrombosis or pulmonary embolism were randomly selected as the controls. The cases and the controls were matched with age and comorbidities. Ever use of tamoxifen was defined as subjects who had at least a prescription for tamoxifen before index date. Never use of tamoxifen was defined as subjects who never had a prescription for tamoxifen before index date. We used the multivariable logistic regression model to calculate the odds ratio (OR) and the 95% confidence interval (CI) of deep vein thrombosis or pulmonary embolism associated with tamoxifen use.
After adjustment for confounding variables, the adjusted OR of deep vein thrombosis or pulmonary embolism was 1.95 for subjects with ever use of tamoxifen (95% CI 1.45, 2.62), as compared with never use of tamoxifen. In addition, atrial fibrillation (adjusted OR 3.73, 95% CI 1.89, 7.35) and chronic kidney disease (adjusted OR 1.72, 95% CI 1.06, 2.80) were also associated with deep vein thrombosis or pulmonary embolism.
Tamoxifen use is associated with 1.95-fold increased odds of deep vein thrombosis or pulmonary embolism among older women with breast cancer in Taiwan.
Effectiveness of high-intensity laser therapy in the treatment of musculoskeletal disorders
Authors: Song Hyun Jin , Seo Hyun-Ju , Lee Youngjin , Kim Sung Kyu 
Published: December 2018

Abstract

Background:
Although high-intensity laser therapy (HILT) has been used for the management of musculoskeletal disorders (MSD), studies examining the effectiveness of HILT have been limited. We investigated the effectiveness of HILT in MSD using a systematic review and meta-analysis.

Methods:
We searched the ovid MEDLINE, ovid Embase, Cochrane CENTRAL library, and Web of Science until January, 2018. Relevant studies concerning the effectiveness of HILT in patients with MSD were included. Both placebo and active controls were considered as comparators and only randomized controlled trial (RCT) design studies were included. Risk of bias (ROB) was used for the quality assessment of the RCT. For continuous variables, a meta-analysis was conducted using an inverse variance random effects model. The mean difference (MD) for visual analog scale pain and standardized mean difference (SMD) for disability were applied.

Results:
Twelve studies were selected for this systematic review. In 11 studies, comprising 736 patients, pain was significantly improved by HILT compared with a control group (MD: −1.01; 95% confidence interval [CI]: −1.28 to −0.74). From the analysis of 688 patients from 10 studies, the pooled standardized mean difference (SMD) of HILT showed a significant improvement in disability scores compared with those in the control group (SMD, −1.09; 95% CI −1.77, −0.41). In subgroup analysis by treatment regions, the mean difference (MD) in neck pain was the highest at −1.02 (95% CI: −1.45, −0.58) than in controls, followed by back pain (MD, −0.91; 95% CI: −1.24, −0.59).

Conclusions:
The results of this study show that HILT treatment for back and neck pain significantly improved pain and disability scores compared with controls. The ROB of the included studies was moderate; however, significant heterogeneity existed. Thus, additional well-designed studies involving larger samples with long-term follow-up are needed to further assess each laser application, treatment region, and comparator.
Application of dynamic monitoring of genomic profiles in non-small cell lung cancer
Authors: Kuang Bo-Hua , Wang Bi-Cheng , Tong Fan , Yang Jin-Song , Zeng Yu-Lan , Cao Ru-Bo , Liu Li 
Published: December 2018

Abstract

Rationale:
Although lung cancer is the leading cause of cancer-related death in the world, targeted therapy plays an essential role in improving the survival of lung cancer. Next-generation sequencing (NGS) technology can dynamically monitor the genomic profiles of tumors and assist cancer diagnosis and treatment.

Patient concerns:
We reported on a 55-year-old man who presented with chest tightness and wheezing for 1 month.

Diagnoses:
The patient was diagnosed with stage cT4N2M1a non-small cell lung cancer (NSCLC) and was found to have wild-type EGFR by pleural effusion cytology.

Interventions:
The patient received systemic treatments, including chemotherapy, targeted therapy, and radiotherapy. During the cancer development, sequential DNA sequencing data that used circulating cell-free tumor DNA, and NGS revealed EGFR L858R and T790M mutations, MYC amplification, and other gene variations.

Outcomes
: The patient died of brain and lung metastases, and had an overall survival as long as 37 months.

Lessons:
The dynamic monitoring of tumor genomic profiles has important implications for NSCLC diagnosis, treatment, and prognosis.
Transcutaneous electric nerve stimulation over acupoints for patients with diarrhea-predominant irritable bowel syndrome
Authors: Han Bo-yu , Shao Qian-Feng , Cong Yu , Guo Song , Mao Xin-Yong , Wei Ru-Han , Wei Wei 
Published: December 2018

Abstract

Background:
At present, drug therapy for diarrhea-predominant irritable bowel syndrome (IBS-D) has made great progress; however, it does not often produce a satisfying curative effect. Transcutaneous electric nerve stimulation over acupoints (Acu-TENS) might be more effective in improving patient's symptoms and producing fewer side-effects as a result.
Although with a great progress of the drug therapy for IBS-D, it is often hard to achieve its satisfactory curative effect. Acu-TENS that may be effective to improve patients’ symptoms and fewer side-effects will be sought. There is no systematic review concerning the efficacy of Acu-TENS for IBS-D published. Therefore, this review aims to systematically evaluate the efficacy of Acu-TENS on IBS-D.

Methods:
Four English (PubMed, EMBASE, The Cochrane Library, Web of Science) and 4 Chinese electronic databases (Biomedical Literature Database, CNKI, VIP, Wanfang Database) will be searched from their inception to November 26, 2018. Randomized controlled trials that evaluated the effect of Acu-TENS on patients with IBS-D will be included. The primary outcome measures will include average weekly stool frequency, visual analog scale (VAS), and the Bristol scale. The secondary outcome measures will include the MOS 36-item short-form health survey (SF-36), IBS Quality of Life Questionnaire (IBS-QOL), severity of IBS symptoms (IBS-SSS), and rectal perception. Quality evaluation and data extraction will be independently undertaken, respectively. The data from the eligible trials will be analyzed by RevMan5.3.

Results:
For patients with IBS-D, this systematic review will provide evidences related to the efficacy of Acu-TENS in these evaluation aspects, stool frequency, VAS and the Bristol scale, SF-36, IBS-QOL, IBS-SSS, and rectal perception.

Conclusion:
This evidence may be useful to medical workers with regard to the use of Acu-TENS in the treatment of IBS-D.

PROSPERO registration number: PROSPERO CRD442018109294.
Prognostic value of pre-dialysis blood pressure and risk threshold on clinical outcomes in hemodialysis patients
Authors: Hara Masatoshi , Tanaka Shigeru , Taniguchi Masatomo , Fujisaki Kiichiro , Torisu Kumiko , Masutani Kosuke , Hirakata Hideki , Nakano Toshiaki , Tsuruya Kazuhiko , Kitazono Takanari 
Published: December 2018

Abstract
The influence of pre-dialysis blood pressure (BP) on the prognosis of hemodialysis (HD) patients is still inconclusive.
A total of 3436 HD patients were prospectively followed up for 4 years. The patients were divided into quintiles of pre-dialysis systolic BP (SBP) and diastolic BP (DBP) levels [mm Hg]: Quintile 1 (Q1), SBP <134, DBP <66; Q2, SBP 134 to 147, DBP 66 to 72; Q3, SBP 148 to 158, DBP 73 to 79; Q4, SBP 159 to 171, DBP 80 to 85; Q5, SBP ≥172, DBP ≥86. The association between the pre-dialysis BP and outcomes were examined using a Cox proportional hazards model.
During a 4-year follow-up period, 564 (16.4%) patients died of any cause and 590 (17.2%) developed cardiovascular (CV) events. The lowest level of pre-dialysis SBP group (Q1) showed a significantly increased risk of all-cause mortality (hazard ratio [HR] 1.83, 95% confidence interval [CI] 1.40–2.39) and the highest group (Q5) significantly increased risk of CV events (HR 1.31, 95% CI 1.02–1.68) compared with the reference group (Q3), respectively. The highest level of pre-dialysis DBP group was significantly associated with increased risk for both all-cause mortality and CV events. Restricted cubic spline analysis for BP and outcomes suggested the optimal pre-dialysis BP value associated with the lowest risk of outcomes was SBP 152 mm Hg for all-cause mortality, SBP 143 mm Hg for CV events, and DBP 68 mm Hg for all-cause mortality.
Our results suggested that pre-dialysis BP was independently associated with all-cause mortality and CV events among Japanese HD patients.
Persistent HPV-16 infection leads to recurrence of high-grade cervical intraepithelial neoplasia
Authors: Byun Jung Mi , Jeong Dae Hoon , Kim Young Nam , Jung Eun Jung , Lee Kyung Bok , Sung Moon Su , Kim Ki Tae 
Published: December 2018

Abstract
High-grade cervical intraepithelial neoplasia (CIN) is a precancerous lesion of cervical cancer. The aims of this study were to evaluate the risk factors for recurrence of high-grade CIN and to determine if the specific genotype of human papillomavirus (HPV) is a predictor of recurrent high-grade CIN. Between January 2010 and December 2014, 172 patients with CIN 2+ underwent cold knife conization or a loop electrosurgical excision. The HPV DNA chip was used to detect HPV. Recurrent lesions were histologically confirmed and considered to be recurrence of CIN2+. We compared the recurrence rate in patients who did and did not have HPV infection after treatment. One hundred forty-eight (86%) patients had HPV infection before treatment. The first follow-up HPV test was performed on average 4.6 months after treatment and the recurrence rate for high-grade CIN was 3.5%. Fifty-eight patients (33.7%) were found to have HPV infection after treatment; of these, 14 (24.1%) had HPV genotype 16 and/or 18. Eleven patients had persistent HPV16 and/or 18 infection and 3 had new HPV 16 infection after treatment (78.6% and 21.4%, P = .001); the HPV 16 genotype was significantly correlated with recurrent disease and persistent infection after treatment (P = .013 and P = .054, respectively, [OR], 19.4; 95% [CI], 1.89–198.79). Recurrence of high-grade CIN was related to HPV infection after treatment, and persistent HPV16 infection was the most important factor for recurrence. Therefore, HPV vaccination for the HPV16 genotype and regular follow-up with HPV testing after treatment may be useful for preventing recurrent high-grade CIN.
Use of statins and the risk of delirium in critically ill and surgical patients
Authors: Zeng Hai , Li Zunjiang , He Guoxin , Han Yanhong , Fu Wenbin , Wen Junru 
Published: December 2018

Abstract

Background:
The critically ill and surgical patients are at significant risk of delirium, which is associated with a high morbidity and mortality. The association between statin use and the incidence of delirium is still controversial. In this article, we will perform a systematic review and meta-analysis of published studies to evaluate the effectiveness of statins for the prophylaxis of delirium among critically ill and surgical patients.

Methods:
We will conduct a systematic literature search in EMBASE, PubMed, and the Cochrane Library from inception date to October 2018 for randomized controlled trials (RCTs) and observational studies (either cohort or case-control studies) investigating the association between use of statins and delirium risk. The Cochrane Collaboration's tool for evaluating the risk of bias and Newcastle-Ottawa scale (NOS) will be used to assess the methodological quality of RCTs and observational studies, separately. The primary outcome will be the risk of incident delirium associated with statin use. Pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) will be calculated by a random-effects or fixed-effects model according to heterogeneity among included studies. Subgroup analyses, meta-regression method, and assessment of publication bias will be also performed. Statistical analyses will be conducted with RevMan (version 5.3.5) and Stata (version 14.0) software. In addition, the grading of recommendations assessment, development and evaluation (GRADE) approach will be applied to evaluate the quality of evidence.

Results:
The study will provide a high-quality synthesis and evaluate the effectiveness of statins for delirium prevention among critically ill and surgical patients.

Conclusions:
The systematic review and meta-analysis will provide convincing evidence concerning the effect of statins against delirium in critically ill and surgical patients.
Efficacy of mineralocorticoid receptor antagonists in postmyocardial infarction patients with or without left ventricular dysfunction
Authors: Xu Yan , Qiu Zhiqiang , Yang Renqiang , Wu Yanqing , Cheng Xiaoshu 
Published: December 2018

Abstract

Background:
There is heated debate about the benefits of using mineralocorticoid receptor antagonists (MRAs) in addition to standard therapy in patients admitted for myocardial infarction (MI) with or without left ventricular dysfunction (LVD).

Methods:
Randomized controlled trials (RCTs) were scanned by a formal search of electronic databases (PubMed, EMBASE, Cochrane Library, Ovid, and clinical trials) from their inception to April 2018. A meta-analysis was conducted using Review Manager 5.3 to identify studies reporting the efficacy of MRAs use in post-MI patients with or without LVD.

Results:
Thirteen RCTs involving 11,365 individuals were eligible for this study. MRAs treatment reduced all-cause mortality by 16%, cardiovascular death by 16%, and death from heart failure (HF) by 22% in post-MI patients. MRAs use reduced all-cause mortality by 13% and cardiovascular death by 15% in post-MI patients with LVD, but there was no significant difference in all-cause mortality and cardiovascular death in post-MI patients without LVD (relative ratios [RR] 0.83, 95% confidence interval [CI] 0.26–2.69, P = .76, I2 = 0%; RR 1.01, 95% CI 0.33–3.09, P = .99, I2 = 0%). In 6 RCTs involving post-MI patients, MRAs treatment had a significant effect on improving left ventricular ejection fraction (LVEF) (mean difference 3.33, 95% CI 0.91–5.75, P = .007, I2 = 94%). Patients treated with MRAs did not show a decrease in recurrent MI or repeat revascularization compared with patients treated without MRAs (RR 0.95, 95% CI [0.80–1.12], P = .54, I2 = 0%; RR 1.09, 95% CI [0.79–1.50], P = .61, I2 = 0%). However, MRAs treatment significantly increased the incidence of hyperkalemia compared with patients treated without MRAs (RR 2.05, 95% CI [1.60, 2.61], P < .00001, I2 = 49%).

Conclusion:
MRAs treatment reduced all-cause mortality, cardiovascular death, and death from HF in post-MI patients. MRAs treatment also demonstrated a significant improvement in LVEF. MRAs reduced cardiovascular death and all-cause mortality in patients with LVD. Eplerenone significantly reduced all-cause mortality and cardiovascular death in post-MI patients. However, MRAs failed to show any cardiovascular benefit in post-MI patients without LVD.
Trends and correlation between antibiotic usage and resistance pattern among hospitalized patients at university hospitals in Korea, 2004 to 2012
Authors: Kim Bongyoung , Kim Yeonjae , Hwang Hyeonjun , Kim Jieun , Kim Shin-Woo , Bae In-Gyu , Choi Won Suk , Jung Sook In , Jeong Hye Won , Pai Hyunjoo 
Published: December 2018

Abstract
The aim of this study was to evaluate the changing pattern of antibiotic usage and antimicrobial resistance of bacterial pathogens among hospitalized patients in Korea. We simultaneously investigated the correlation between antimicrobial resistance and antibiotic consumption.
Data on total antibiotic prescriptions, patient days, and antimicrobial sensitivity tests among inpatients from 6 university hospitals in Korea in 2004, 2008, and 2012 were collected. The consumption of each antibiotic class was converted to defined daily dose/1000 patient-days by using the anatomical therapeutic chemical classification system by the World Health Organization. We defined third-generation cephalosporins (3rd CEPs), fourth-generation cephalosporins, beta-lactam/beta-lactamase inhibitors, and fluoroquinolones (FQs) as broad-spectrum antibiotics and carbapenems, tigecycline, glycopeptides, oxazolidinone, and polymyxin as antibiotics against multidrug-resistant (MDR) pathogens.
A 15.1% decrease in total antibiotic consumption was observed in 2012 compared to that observed in 2004. In contrast, a 10.2% and 70.7% increase in broad-spectrum antibiotics and antibiotics against MDR pathogens were observed, respectively, in the same period. The resistance rate of Escherichia coli to 3rd CEPs (17.6% in 2004, 21.7% in 2008, and 33.8% in 2012, P <.001) and ciprofloxacin (37.5% in 2004, 38.7% in 2008, and 46.6% in 2012, P = .001) demonstrated a significantly increasing trend. Similarly, the resistance rate of Klebsiella pneumoniae to 3rd CEPs (34.3% in 2004, 33.7% in 2008, and 44.5% in 2012, P <.001) gradually increased. Resistance of Acinetobacter baumanii and Pseudomonas aeruginosa to imipenem significantly increased throughout the study period (A baumanii: 8.9% in 2004, 40.8% in 2008, and 65.3% in 2012, P
<.001; P aeruginosa: 25.1% in 2004, 31.5% in 2008, and 29.7% in 2008, P = .050).
The consumption of carbapenems and FQs demonstrated significant positive correlation for resistance of E coli or K pneumoniae to 3rd CEPs as well as E coli or K pneumoniae to ciprofloxacin. Increasing resistance of A baumanii to ciprofloxacin was significantly correlated with increasing consumption of FQs; increasing resistance of A baumanii to imipenem was significantly correlated with increasing consumption of carbapenems.
In conclusion, overall antimicrobial resistance increased and consumption of broad-spectrum antibiotics and antibiotics against MDR pathogens subsequently increased in Korean hospitals.