bluuebunny/crossref_metadata_2025_split huggingface dataset:
Limits on Limitations: The Essence of Fundamental Rights in the EU
Authors: Lenaerts Koen 
Published: September 2019

AbstractThe concept of the essence of a fundamental right—set out in Article 52(1) of the Charter of Fundamental Rights of the European Union (the “Charter”)—operates as a constant reminder that our core values as Europeans are absolute. In other words, they are not up for balancing. As the seminal judgment of the Court of Justice of the European Union (the “CJEU”) in Schrems shows, where a measure imposes a limitation on the exercise of a fundamental right that is so intense and so comprehensive that it calls into question that right as such, that measure is incompatible with the Charter, as it deprives the right at issue of its essence. This is so without the need for a balancing exercise of competing interests, because a measure that compromises the very essence of a fundamental right is automatically disproportionate. Therefore, the present contribution supports the contention that in order for the concept of essence to function in a constitutionally meaningful way, both EU and national courts should apply the “respect-for-the-essence test” before undertaking a proportionality assessment.
The Essence of Rights: An Unreliable Boundary?
Authors: Tridimas Takis , Gentile Giulia 
Published: September 2019

AbstractArticle 52(1) of the EU Charter of Fundamental Rights lays down respect for the essence of right as one of the requirements that limitations on rights must respect. This provision is not innovative, as it formalizes into EU law the distinction between “core” and “periphery” of rights present in many national constitutions and in the ECJ and ECtHR case law. Nonetheless, the express reference to essence has given unprecedented resonance to that concept. Essence as the “limit of limits” has a Janus-like character. On the one hand, it pronounces that every fundamental right bears a minimum content which is ringfenced from interference by public and private actors. On the other hand, it stresses the malleability of rights and their social function. The core/periphery dichotomy reflects a balancing act moored in European legal tradition whose symbolism outperforms its utility as a judicial tool. This Article examines the essence clause of the Charter in light of the ECJ case law and the constitutional traditions of the Member States and assesses its role in the framework of fundamental rights protection in EU law. The Article first attempts a classification of rights limitations clauses in national constitutions, following which it discusses the interpretation of essence by the Spanish and the Italian Constitutional Courts. The Article then engages with a theoretical discussion of the concept of essence and examines the case law of the ECJ. Lastly, it looks at the limitations of the concept as a rights protection instrument in EU law.
The “Essence” of International Human Rights
Authors: Thielbörger Pierre 
Published: September 2019

AbstractWhile the “essence” of EU fundamental rights has received much attention following the CJEU’s Schrems decision, the concept of “essence” remains much less examined in international human rights law. Nonetheless, a concept of “essence” for human rights can also be found in international law. This Article discusses different aspects of the “essence” concept in international human rights law, namely non-derogability, non-restrictability, and minimum core, in three steps. First, the Article looks at civil political rights and socioeconomic rights separately and identifies two different approaches to the concept of essence for each of the two categories: While for civil and political rights the concept of essence is mainly linked to the notions of non-derogability and non-restrictability, for socioeconomic rights, the concept refers mainly to the states’ obligation to guarantee an essential level of protection independent of their resource limitations. Second, the Article continues by reading the two approaches together and identifies certain elements of an overarching “essence” concept. Finally, the Article discusses the relationship between the CJEU’s “essence” jurisprudence and the related concepts in international law and concludes with two theses: First, international law deserves more attention when reflecting on the EU’s concept of essence. It equally employs concepts of “essence” and also informs the development and interpretation of EU law. Second, when engaging with the question of whether the EU law should draw lessons from its international counterpart on the notion of “essence,” one must contemplate drawbacks for EU law that the concept has presented for international law.
Outcomes of extended-spectrum beta-lactamases producing Enterobacteriaceae colonization among patients abdominal surgery patients
Authors: Apisarnthanarak Anucha , Kondo Sumalee , Mingmalairak Chatchai , Mahawongkajit Prasit , Juntong Jatupong , Limpavitayaporn Palin , Sriussadaporn Ekkapak , Tongyoo Assanee , Mundy Linda M. 
Published: September 2019

AbstractPreoperative enteric screening for extended-spectrum β-lactamase (ESBL)–producing Enterobacteriaceae was conducted in 360 patients prospectively observed for surgical site infection (SSI). ESBL colonization (adjusted odds ratio [aOR], 2.4) and dirty wound classification (aOR, 3.6) were associated with SSI; no association between carbapenem prophylaxis and reduction in SSI was detected.
Geophysical signature of a World War I tunnel-like anomaly in the Forni Glacier (Punta Linke, Italian Alps)
Authors: Francese R. G. , Bondesan A. , Giorgi M. , Picotti S. , Carcione J. , Salvatore M. C. , Nicolis F. , Baroni C. 
Published: September 2019

AbstractGlobal warming and the associated glacier retreat recently revealed the entrance to an ice–rock tunnel, at an altitude of ~3600 m a.s.l., in the uppermost portion of the Forni Glacier in the Central Italian Alps. The tunnel served as an entrance to an Austro-Hungarian cableway station excavated in the rocks during the Great War just behind the frontline. A comprehensive geophysical survey, based on seismic and ground-penetrating radar profiling, was then undertaken to map other possible World War I (WWI) remains still embedded in the ice. The ice–rock interface was reconstructed over the entire saddle and in the uppermost portion of the glacier. A prominent linear reflector was surprisingly similar to the common response of buried pipes. The reflector orientation, almost longitudinal to the slope, does not seem to be compatible with a glacial conduit or with other natural features. Numerical simulations of a series of possible targets constrained interpretation to a partly water-filled rounded shape cavity. The presence of a preserved WWI tunnel connecting Mount Vioz and Punta Linke could be considered a realistic hypothesis. The Forni glacier could be still considered polythermal and comprised of cold ice without basal sliding in its top portion.
Incompressible analytical models for spinning-down pulsars
Authors: Giliberti E. , Antonelli M. , Cambiotti G. , Pizzochero P. M. 
Published: September 2019

Abstract
We study a class of Newtonian models for the deformations of non-magnetised neutron stars during their spin-down. All the models have an analytical solution which allows to easily grasp the dependence of the strain on the star’s main physical quantities, such as radius, mass, and crust thickness.
We first use the model proposed by Franco, Link, and Epstein that depicts the star as made of a fluid core and an elastic crust with the same density, to compare the response to a decreasing centrifugal force on stars having different masses and equations of state. We find that the strain angle is peaked at the equator and its maximum value decreases as a function of the mass.
Afterwards, we introduce a second, more refined, model in which the core and the crust have different densities, and the gravitational potential of the deformed body is self-consistently accounted for. The strain angle is still a decreasing function of the stellar mass, but now its maximum value is typically peaked at the poles and is larger (by a factor of four) than the corresponding value in the one-density model.
Finally, within the present analytic approach, we evaluate the impact of the Cowling approximation: when the perturbations of the gravitational potential are neglected, we find an underestimation of the centrifugal effect on the star, since the strain angle is about 40% of the one obtained with the complete model.
The emission and scintillation properties of RRAT J2325−0530 at 154 MHz and 1.4 GHz
Authors: Meyers B. W. , Tremblay S. E. , Bhat N. D. R. , Shannon R. M. , Ord S. M. , Sobey C. , Johnston-Hollitt M. , Walker M. , Wayth R. B. 
Published: September 2019

AbstractRotating Radio Transients (RRATs) represent a relatively new class of pulsar, primarily characterised by their sporadic bursting emission of single pulses on time scales of minutes to hours. In addition to the difficulty involved in detecting these objects, low-frequency (

$ \lt 300\,\text{MHz}$

) observations of RRATs are sparse, which makes understanding their broadband emission properties in the context of the normal pulsar population problematic. Here, we present the simultaneous detection of RRAT J2325−0530 using the Murchison Widefield Array (154 MHz) and Parkes radio telescope (

$1.4\,\text{GHz}$

). On a single-pulse basis, we produce the first polarimetric profile of this pulsar, measure the spectral index (

$\alpha={-2.2\pm 0.1}$

), pulse energy distributions, and present the pulse rates in the context of detections in previous epochs. We find that the distribution of time between subsequent pulses is consistent with a Poisson process and find no evidence of clustering over the

$\sim\!1.5\,\text{h}$

observations. Finally, we are able to quantify the scintillation properties of RRAT J2325−0530 at 1.4 GHz, where the single pulses are modulated substantially across the observing bandwidth, and show that this characterisation is feasible even with irregular time sampling as a consequence of the sporadic emission behaviour.
Are remitted affective disorders and familial risk of affective disorders associated with metabolic syndrome, inflammation and oxidative stress? – a monozygotic twin study
Authors: Ottesen Ninja Meinhard , Meluken Iselin , Frikke-Schmidt Ruth , Plomgaard Peter , Scheike Thomas , Fernandes Brisa S. , Berk Michael , Poulsen Henrik Enghusen , Kessing Lars Vedel , Miskowiak Kamilla , Vinberg Maj 
Published: September 2019

AbstractBackgroundMetabolic syndrome (MetS) is associated with reduced life expectancy in patients with affective disorders, however, whether MetS also plays a role before the onset of affective disorder is unknown. We aimed to investigate whether MetS, inflammatory markers or oxidative stress act as risk factors for affective disorders, and whether MetS is associated with increased inflammation and oxidative stress.MethodsWe conducted a high-risk study including 204 monozygotic (MZ) twins with unipolar or bipolar disorder in remission or partial remission (affected), their unaffected co-twins (high-risk) and twins with no personal or family history of affective disorder (low-risk). Metabolic Syndrome was ascertained according to the International Diabetes Federation (IDF) criteria. Inflammatory markers and markers of oxidative stress were analyzed from fasting blood and urine samples, respectively.ResultsThe affected and the high-risk group had a significantly higher prevalence of MetS compared to the low-risk group (20%v.15%v.2.5%,p= 0.0006), even after adjusting for sex, age, smoking and alcohol consumption. No differences in inflammatory and oxidative markers were seen between the three groups. Further, MetS was associated with alterations in inflammatory markers, and oxidative stress was modestly correlated with inflammation.ConclusionMetabolic syndrome is associated with low-grade inflammation and may act as a risk factor and a trait marker for affective disorders. If confirmed in longitudinal studies, this suggests the importance of early intervention and preventive approaches targeted towards unhealthy lifestyle factors that may contribute to later psychopathology.
Inattention in boys from low-income backgrounds predicts welfare receipt: a 30-year prospective study
Authors: Vergunst Francis , Tremblay Richard E. , Nagin Daniel , Zheng Yao , Galera Cedric , Park Jungwee , Beasley Elizabeth , Algan Yann , Vitaro Frank , Côté Sylvana M. 
Published: September 2019

AbstractBackgroundChildhood disruptive behaviors are highly prevalent and associated with adverse long-term social and economic outcomes. Trajectories of welfare receipt in early adulthood and the association of childhood behaviors with high welfare receipt trajectories have not been examined.MethodsBoys (n = 1000) from low socioeconomic backgrounds were assessed by kindergarten teachers for inattention, hyperactivity, aggression, opposition, and prosociality, and prospectively followed up for 30 years. We used group-base trajectory modeling to estimate trajectories of welfare receipt from age 19–36 years using government tax return records, then examined the association between teacher-rated behaviors and trajectory group membership using mixed effects multinomial regression models.ResultsThree trajectories of welfare receipt were identified: low (70.8%), declining (19.9%), and chronic (9.3%). The mean annual personal employment earnings (US$) for the three groups at age 35/36 years was $36 500 (s.d. = $24 000), $15 600 (s.d. = $16 275), and $1700 (s.d. = $4800), respectively. Relative to the low welfare receipt group, a unit increase in inattention (mean = 2.64; s.d. = 2.32, range = 0–8) at age 6 was associated with an increased risk of being in the chronic group (relative risk ratio; RRR = 1.16, 95% CI 1.03–1.31) and in the declining group (RRR = 1.13, 95% CI 1.03–1.23), after adjustment for child IQ and family adversity, and independent of other behaviors. Family adversity was more strongly associated with trajectories of welfare receipt than any behavior.ConclusionsBoys from disadvantaged backgrounds exhibiting high inattention in kindergarten are at elevated risk of chronic welfare receipt during adulthood. Screening and support for inattentive behaviors beginning in kindergarten could have long-term social and economic benefits for individuals and society.
Transparency and participatory aspects of investor-state dispute settlement in the EU ‘new wave’ trade agreements
Authors: Lam Joanna , Ünüvar Güneş 
Published: September 2019

AbstractThis article scrutinizes the investment chapters in the new EU Free Trade Agreements from a transparency perspective. The article examines the claims that the dispute settlement mechanisms in the new treaties are sufficiently participatory and more transparent than their predecessors. Procedural standards related to confidentiality of proceedings shall be analysed in the context of existing transparency safeguards in investment arbitration. In addition to procedural guarantees of transparency, the article examines relevant substantive rules affecting participatory aspects of dispute settlement. Furthermore, the article discusses forum-shopping strategies of the parties in the field of investment-related disputes, including internal forum-shopping and parallel proceedings using different procedural mechanisms. In this context, lessons from other fields such as international commercial arbitration related to transparency (in cases in which public interest is present) are highlighted. The proposal for the establishment of an integrated, multilateral court for investment cases is also invoked.
Significant Electric Field Perturbations in Low Latitude Ionosphere due to the Passage of Two Consecutive ICMEs During 6–8 September 2017
Authors: Rout Diptiranjan , Pandey Kuldeep , Chakrabarty D. , Sekar R. , Lu Xian 
Published: September 2019

AbstractThis investigation shows that the significant electric field disturbances in the dip‐equatorial ionosphere during the geomagnetic storm of 6–8 September 2017 are due to the passage of two consecutive interplanetary coronal mass ejections (ICMEs). During the passage of the first ICME sheath, a long duration (∼10 hr) prompt penetration (PP) event is operational in which 60‐min periodic component is found to be present in vertical drift as well as in equatorial electrojet, but the 45‐min periodicity, though present, is not significant in equatorial electrojet. On 8 September, the shock associated with the second ICME enhances theFregion vertical plasma drift to ∼150 m/s in the evening hours which is one of the highest vertical drift ever measured over Jicamarca. The same PP electric field causes unusually large enhancement of the equatorial electrojet strength to ∼135 nT in the early morning hours over the Philippine sector. The disturbance dynamo (DD) that follows the storm causes an upward vertical drift of ∼55 m/s during postmidnight hours over Jicamarca which is one of the highest observed. These unusually large electric field perturbations cause significant changes in theFregion plasma fountain. It is shown that these electric field perturbations cannot be accounted by PP/DD electric field associated with the geomagnetic storm only and significant contribution from substorm is conspicuous. Therefore, the present investigation highlights the need to evaluate the role of substorm in unusually large electric field perturbations over equatorial ionosphere.
Causes of death in preterm neonates (<33 weeks) born in tertiary care hospitals in India: analysis of three large prospective multicentric cohorts
Authors: Jain Kajal , Sankar M. Jeeva , Nangia Sushma , Ballambattu Vishnu Bhat , Sundaram Venkataseshan , Ramji Siddharth , Plakkal Nishad , Kumar Praveen , Jain Ashish , Sivanandan Sindhu , Vishnubhatla Sreenivas , Chellani Harish , Deorari Ashok , Paul Vinod K. , Agarwal Ramesh 
Published: September 2019

Abstract
Objective
To estimate the direct causes of mortality among preterm neonates <33 weeks’ gestation by examining three large multicentric, hospital-based datasets in India.

Method
Three prospective hospital-based datasets: National Neonatal Perinatal Database (NNPD) of India, Delhi Neonatal Infection Study (DeNIS) cohort, and Goat Lung Surfactant Extract (GLSE)-Plus cohort were analyzed to study the causes of death among preterm neonates of less than 33 weeks’ gestation admitted to the participating tertiary care hospitals in India.

Results
A total of 8024 preterm neonates were admitted in the three cohorts with 2691 deaths. Prematurity-related complications and sepsis contributed to 53.5% and 19.8% of deaths in the NNPD cohort, 51.0% and 25.0% in the DeNIS cohort, and 39.7% and 40.9% in GLSE-Plus cohort, respectively.

Conclusions
Nearly a quarter (20-40%) of preterm neonates less than 33 weeks’ gestation admitted to Indian NICUs died of sepsis. The study results have implications for health policies targeted to reduce the neonatal mortality rate in India.
EPHA2 mutations with oncogenic characteristics in squamous cell lung cancer and malignant pleural mesothelioma
Authors: Tan Yi-Hung Carol , Srivastava Saumya , Won Brian M. , Kanteti Rajani , Arif Qudsia , Husain Aliya N. , Li Hubert , Vigneswaran Wickii T. , Pang Ka-Ming , Kulkarni Prakash , Sattler Martin , Vaidehi Nagarajan , Mambetsariev Isa , Kindler Hedy L. , Wheeler Deric L. , Salgia Ravi 
Published: September 2019

AbstractSquamous cell carcinoma (SCC) and malignant pleural mesothelioma (MPM) are thoracic malignancies with very poor prognosis and limited treatment options. It is an established fact that most of the solid tumors have overexpression of EPHA2 receptor tyrosine kinase. EPHA2 is known to exhibit opposing roles towards cancer progression. It functions in inhibiting cancer survival and migration via a ligand and tyrosine kinase dependent signaling (Y772). Whereas it is known to promote tumor progression and cell migration through a ligand-independent signaling (S897). We analyzed the expression profile and mutational status of the ephrin receptor A2 (EPHA2) in SCC and MPM cell lines and primary patient specimens. The EPHA2 receptor was found to be either overexpressed, mutated or amplified in SCC and MPM. In particular, the EPHA2 mutants A859D and T647M were interesting to explore, A859D Y772 dead mutant exhibited lower levels of phosphorylation at Y772 compared to T647M mutant. Molecular Dynamics simulations studies suggested that differential changes in conformation might form the structural basis for differences in the level of EPHA2 activation. Consequently, A859D mutant cells exhibited increased proliferation as well as cell migration compared to controls and T647M mutant. Kinomics analysis demonstrated that the STAT3 and PDGF pathways were upregulated whereas signaling through CBL was suppressed. Considered together, the present work has uncovered the oncogenic characteristics of EPHA2 mutations in SSC and MPM reinstating the dynamics of different roles of EPHA2 in cancer. This study also suggests that a combination of doxazosin and other EPHA2 inhibitors directed to inhibit the pertinent signaling components may be a novel therapeutic strategy for MPM and Non-small cell lung cancer patients who have either EPHA2 or CBL alterations.
Photo-editable macromolecular information
Authors: König Niklas Felix , Al Ouahabi Abdelaziz , Oswald Laurence , Szweda Roza , Charles Laurence , Lutz Jean-François 
Published: September 2019

AbstractLight-induced alteration of macromolecular information plays a central role in biology and is known to influence health, aging and Darwinian evolution. Here, we report that light can also trigger sequence variations in abiotic information-containing polymers. Sequence-coded poly(phosphodiester)s were synthesized using four phosphoramidite monomers containing either photo-sensitive or photo-inert substituents. These monomers allow different sequence manipulations. For instance, using two light-cleavable monomers containing o-nitrobenzyl ether and o-nitroveratryl ether motifs, photo-erasable digital polymers were prepared. These polymers can be decoded by tandem mass spectrometry but become unreadable after UVA exposure. The opposite behavior, i.e. photo-revealable sequences, was obtained with polymers made of two isobaric monomers containing light-cleavable o-nitrobenzyl ether and light-inert p-nitrobenzyl ether substituents. Furthermore, when the latter two monomers were used in conjunction with a third monomer bearing a light-inert OH group, site-directed photo-mutations were induced in synthetic polymers. This was used herein to change the meaning of binary sequences.
Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
Authors: Akula Murali K. , Ibrahim Mohamed X. , Ivarsson Emil G. , Khan Omar M. , Kumar Israiel T. , Erlandsson Malin , Karlsson Christin , Xu Xiufeng , Brisslert Mikael , Brakebusch Cord , Wang Donghai , Bokarewa Maria , Sayin Volkan I. , Bergo Martin O. 
Published: September 2019

AbstractRho family proteins are prenylated by geranylgeranyltransferase type I (GGTase-I), which normally target proteins to membranes for GTP-loading. However, conditional deletion of GGTase-I in mouse macrophages increases GTP-loading of Rho proteins, leading to enhanced inflammatory responses and severe rheumatoid arthritis. Here we show that heterozygous deletion of the Rho family gene Rac1, but not Rhoa and Cdc42, reverses inflammation and arthritis in GGTase-I-deficient mice. Non-prenylated Rac1 has a high affinity for the adaptor protein Ras GTPase-activating-like protein 1 (Iqgap1), which facilitates both GTP exchange and ubiquitination-mediated degradation of Rac1. Consistently, inactivating Iqgap1 normalizes Rac1 GTP-loading, and reduces inflammation and arthritis in GGTase-I-deficient mice, as well as prevents statins from increasing Rac1 GTP-loading and cytokine production in macrophages. We conclude that blocking prenylation stimulates Rac1 effector interactions and unleashes proinflammatory signaling. Our results thus suggest that prenylation normally restrains innate immune responses by preventing Rac1 effector interactions.