bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome‐wide transcriptome analysis of Aβ deposition on PET in a Korean cohort
Authors: Park Tamina , Hwang Jiyun , Liu Shiwei , Chaudhuri Soumilee , Han Sang Won , Yi Dahyun , Byun Min Soo , Huang Yen‐Ning , Rosewood Thea , Jung Gijung , Kim Min Jeong , Ahn Hyejin , Lee Jun‐Young , Kim Yu Kyeong , Cho MinYoung , Bice Paula J. , Craft Hannah , Risacher Shannon L. , Gao Hongyu , Liu Yunlong , Kim SangYun , Park Young Ho , Lee Dong Young , Saykin Andrew J. , Nho Kwangsik 
Published: November 2024

AbstractINTRODUCTIONDespite the recognized importance of including ethnic diversity in Alzheimer's disease (AD) research, substantial knowledge gaps remain, particularly in Asian populations.METHODSRNA sequencing was performed on blood samples from the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE) to perform differential gene expression (DGE), gene co‐expression network, gene‐set enrichment, and machine learning analyses for amyloid beta (Aβ) deposition on positron emission tomography.RESULTSDGE analysis identified 265 dysregulated genes associated with Aβ deposition and replicated three AD‐associated genes in an independent Korean cohort. Network analysis identified two modules related to pathways including a natural killer (NK) cell–mediated immunity. Machine learning analysis showed the classification of Aβ positivity improved with the inclusion of gene expression data.DISCUSSIONOur results in a Korean population suggest Aβ deposition‐associated genes are enriched in NK cell–mediated immunity, providing a better understanding of AD molecular mechanisms and yielding potential diagnostic and therapeutic strategies.Highlights
Dysregulated genes were associated with amyloid beta (Aβ) deposition on positron emission tomography in a Korean cohort.
Dysregulated genes in Alzheimer's disease were replicated in an independent Korean cohort.
Gene network modules were associated with Aβ deposition.
Natural killer (NK) cell proportion in blood was associated with Aβ deposition.
Dysregulated genes were related to a NK cell–mediated immunity.
Enhancement of Glutamate Uptake as Novel Antiseizure Approach: Preclinical Proof of Concept
Authors: Kamiński Krzysztof , Socała Katarzyna , Abram Michał , Jakubiec Marcin , Reeb Katelyn L. , Temmermand Rhea , Zagaja Mirosław , Maj Maciej , Kolasa Magdalena , Faron‐Górecka Agata , Andres‐Mach Marta , Szewczyk Aleksandra , Hameed Mustafa Q. , Fontana Andréia C. K. , Rotenberg Alexander , Kamiński Rafał M. 
Published: November 2024

ObjectiveExcitotoxicity is a common hallmark of epilepsy and other neurological diseases associated with elevated extracellular glutamate levels. Thus, here, we studied the protective effects of (R)‐AS‐1, a positive allosteric modulator (PAM) of glutamate uptake in epilepsy models.Methods(R)‐AS‐1 was evaluated in a range of acute and chronic seizure models, while its adverse effect profile was assessed in a panel of standard tests in rodents. The effect of (R)‐AS‐1 on glutamate uptake was assessed in COS‐7 cells expressing the transporter. WAY 213613, a selective competitive EAAT2 inhibitor, was used to probe the reversal of the enhanced glutamate uptake in the same transporter expression system. Confocal microscopy and Western blotting analyses were used to study a potential influence of (R)‐AS‐1 on GLT‐1 expression in mice.Results(R)‐AS‐1 showed robust protection in a panel of animal models of seizures and epilepsy, including the maximal electroshock‐ and 6 Hz‐induced seizures, corneal kindling, mesial temporal lobe epilepsy, lamotrigine‐resistant amygdala kindling, as well as seizures induced by pilocarpine or Theiler's murine encephalomyelitis virus. Importantly, (R)‐AS‐1 displayed a favorable adverse effect profile in the rotarod, the minimal motor impairment, and the Irwin tests. (R)‐AS‐1 enhanced glutamate uptake in vitro and this effect was abolished by WAY 213613, while no influence on GLT‐1 expression in vivo was observed after repeated treatment.InterpretationCollectively, our results show that (R)‐AS‐1 has favorable tolerability and provides robust preclinical efficacy against seizures. Thus, allosteric enhancement of EAAT2 function could offer a novel therapeutic strategy for treatment of epilepsy and potentially other neurological disorders associated with glutamate excitotoxicity. ANN NEUROL 2025;97:344–357
Erneute Untersuchung der Baddeley Reaktion: Zugang zu funktionalisierten Decalinen durch ladungsinduzierte Alkanfunktionalisierung
Authors: Vavrík Miloš , Grant Phillip S. , Kaiser Daniel , Gruene Tim , Maulide Nuno 
Published: November 2024

AbstractC−H‐Funktionalisierung rein aliphatischer Substrate ist eine herausfordernde Aufgabe, da das Fehlen von dirigierenden Gruppen Versuche zur Steuerung der Regioselektivität meist vereitelt. Dies gilt insbesondere für Difunktionalisierungsreaktionen, bei denen die Kontrolle der relativen Stereochemie eine zusätzliche Hürde darstellt. Die Baddeley‐Reaktion an Decalinen ist, trotz Einschränkungen hinsichtlich Ausbeute und Vielseitigkeit, von besonderem Interesse, da sie eine der wenigen bekannten Transformationen ist, die in der aliphatischen C−H‐Funktionalisierung Regio‐ und Stereokontrolle ermöglichen. Hier berichten wir über eine regio‐ und diastereoselektive Methode zur Difunktionalisierung von Decalin, die Zugang zu einem neuen, bisher nicht beschriebenen Regioisomer in synthetisch nützlichen Ausbeuten ermöglicht. Diese Methode wurde erfolgreich auf eine Reihe anderer Alkansubstrate angewandt, was eine unkomplizierte Synthese von Ketoalkoholen aus den einfachsten Alkanbausteinen ermöglicht.
Experimental and kinetic study on the laminar burning velocities of NH3 mixing with hydrous C2H5OH in premixed flames
Authors: Song Yindong , Liu Haocheng , Yang Xiaofeng , Cheng Xiuwei , Xiang Linfeng , Hou Ruida 
Published: November 2024

AbstractIn the present work, the laminar burning velocities of NH3 + hydrous C2H5OH + air flames were measured using the heat flux method at 1 atm with varied equivalence ratios and mixing ratios (with hydrous ethanol molar fractions of 45%–75%). The measurements were carried out at unburned temperatures of 358 and 378 K. The results show that the laminar burning velocities increase with the increase of hydrous ethanol mixing ratio and temperature, indicating that hydrous ethanol contributes to the combustion of NH3 flames. Based on Wang et al.'s CEU‐NH3 mechanism, sensitivity, reaction pathways, and product formation rate analyses were conducted. The results show that the addition of water reduces the laminar burning velocities of mixed fuel. Intermediate radicals such as NH and HNO are crucial for the formation of NO. After adding water, in the preheating zone, the total production rates of key species such as NH3, H, O, and OH radicals and intermediate species like NH2, NH, HNO, and N decrease, leading to a reduction in the total NO generation rate and the peak mole fraction of NO in the reaction zone.
PVA/AMPS hydrogels: Promising adsorbents for wastewater treatment with high efficiency and reusability
Authors: Yadav Paramjeet , Afgan Shere , Singh Shiwani , Prakash Ravi , Maity Pralay , Kumar Rajesh 
Published: November 2024

AbstractA PVAMPS hydrogel was synthesized through chemical cross‐linking and semi‐interpenetration of Poly (vinyl Alcohol) (PVA) and 2‐Acrylamido‐2‐methyl‐1‐propanesulfonic acid (AMPS) with glutaraldehyde in distilled water. Various ratios of PVA/AMPS, namely PVAMPS‐1 (2:1), PVAMPS‐2 (1:1), and PVAMPS‐3 (1:2), were examined to understand their individual impacts on gel formation. The synthesis of hydrogels was confirmed using FT‐IR and solid‐state 13C NMR spectroscopy. The PVAMPS hydrogels demonstrated high efficiency as a selective adsorbent for removing cationic dyes, such as Methylene Blue, Safranine‐O, and Thionine, from aqueous solutions, with over 90% removal of cationic dyes observed within 18 hours. Regeneration and reusability studies revealed that even after four cycles, the adsorption capacity of the PVAMPS hydrogels remained exceptionally high, with removal rates exceeding 90% for Methylene Blue. However, for Safranine‐O and Thionine, the removal rates dropped to 20% and 23%, respectively, after four cycles. These findings underscore the promising potential of PVAMPS hydrogels for the removal of cationic dyes in wastewater treatment.
Preparation and performance of waterborne polyurethane coatings based on the intumescent flame retardant of boron, phosphorus, and nitrogen
Authors: Luo Yaofa , Jiang Ronghua , Xu Yihao , Wang Hui , Qiu Zeping , Huang Jin , Zheng Yuying 
Published: November 2024

AbstractPNB organic flame retardant was synthesized using 4‐formylphenylboronic acid, 4‐aminophenylthiophenol, 9,10‐dihydro‐9‐oxa‐10‐phos‐phaphenanthrene‐10‐oxide (DOPO), and then introduced into the hydroxyl‐terminated polybutadiene acrylonitrile (HTBN) molecular chain to successfully prepare a macromolecular flame retardant, which was used to prepare flame retardant waterborne polyurethane. The mechanical properties, thermal properties, and flame retardancy of waterborne polyurethane (FR‐WPU) were studied using thermogravimetic analysis (TGA), limiting oxygen index (LOI), scanning electron microscope (SEM), cone calorimeter, and universal testing machine, respectively, and the flame retardant mechanism of macromolecular flame retardants was explored. An LOI value of 29.76% and a UL‐94 V‐0 rating could be realized when the APFBH conjugation is 7.5 wt%, showing a significant improvement of melt dripping behavior and flame retardancy. It indicated that the fire resistance of FR‐WPU remarkably improved and displayed both gas and condensed phase mechanism. As the content of APBDH increased, the tensile strength and the elongation at break of FR‐WPU increased firstly and then decreased.
Declines in Freshwater Mussels and Loss of Mussel–Invertebrate Interactions in the Subtropical Waterbodies of Dhaka, Bangladesh
Authors: Ollard Isobel , Aldridge David C. , Jannat Fatima , Chowdhury Gawsia W. 
Published: November 2024

ABSTRACT

Freshwater mussels are a globally threatened taxon, but little is known about population trajectories for species outside Europe and North America. To contribute to understanding of mussel conservation status outside these regions, we surveyed mussel and other invertebrate populations in waterbodies across Dhaka, Bangladesh, to assess population trends and the role of mussels in structuring benthic communities.

We found that mussel populations in Dhanmondi Lake, our focal waterbody, have declined in density by approximately 90% between 2010 and 2023. Lamellidens marginalis declined by 90.8% from an average density of 47.9 ± SE 7.1 mussels 0.25 m−2 in 2010 to 4.4 ± SE 0.7 mussels 0.25 m−2 in 2023, while Indonaia caerulea declined by 89.4% from an average density of 6.6 ± SE 1.0 mussels 0.25 m−2 in 2010 to 0.7 ± SE 0.1 mussels 0.25 m−2 in 2023.

Previously detected associations between mussels and other invertebrate taxa, and between mussels and community composition, have been lost. Non‐mussel invertebrates have also declined significantly, with an average decrease in abundance of 27%, alongside decreases in family richness and Shannon‐Wiener diversity. These declines occurred despite apparent improvements in water quality.

Findings from other waterbodies across Dhaka also suggest the loss of mussel species including L. marginalis, I. caerulea and Parreysia corrugata from some locations, as well as the presence of the non‐native mussel Pilsbryoconcha exilis at river sites.

Our results reflect a wider, global pattern of enigmatic declines in freshwater mussels and the possible loss of associated ecosystem functioning, which may be going unnoticed in less‐studied areas including the subtropics.
Mandible composition and properties in two selected praying mantises (Insecta, Mantodea)
Authors: Roze Malo , Gorb Stanislav N. , Zeimet Timo , Krings Wencke 
Published: November 2024

AbstractInsects process their food with their cuticle‐based mouthparts. These feeding structures reflect their diversity and can, in some cases, showcase adaptations in material composition, mechanical properties, and shape to suit their specific dietary preferences. To pave the way to deeply understand the interaction between mouthparts and food and to determine potential adaptations of the structures to the food, this study focuses on the mandibles of two praying mantis species. Gongylus gongylodes feeds mainly on Diptera, and Sphodromantis lineola forages on larger prey. Employing scanning electron microscopy, the mandibular morphologies were analyzed. The degree of the cuticle tanning was tested using confocal laser scanning microscopy. Furthermore, the contents of transition and alkaline earth metals in the mandible cuticle were studied using energy‐dispersive X‐ray spectroscopy and the mechanical properties tested by nanoindentation. We found that S. lineola mandibles show pronounced gradients of Young's modulus and hardness from the basis to the tip, which might be an adaptation against high stresses during biting and chewing. G. gongylodes, in contrast, did not show pronounced gradients, which may indicate that there is less stress involved in feeding—necessary to test in future studies. The mechanical properties of manidibles in both species are related to the degree of cuticle tanning but also positively correlate with the content of magnesium. These findings enrich our understanding of insect cuticle biology but also present new sets of data on praying mantis structures.
Effect of terracotta drinker and/or water addition of ASPRO‐C plus on behavior, growth, and physiological response of broiler chickens exposed to high temperature
Authors: Cyrille d’Alex Tadondjou Tchingo , Gilhoube Edmond , Djaomanwe Denis , Ledang Narcisse , Ponka Roger , Ngoula Ferdinand , Teguia Alexis 
Published: November 2024

AbstractThis study aimed to evaluate the effects of a terracotta drinker and/or water supplementation with ASPRO‐C Plus on the zootechnical performance of broiler chickens reared in a hot environment. A total of 160 Cobb 500 broiler chicks of 15 days old (240.2 ± 39.82 g) were divided into four treatment groups in a 2 x 2 factorial arrangement of drinker type (plastic or terracotta) and water with or without ASPRO‐C Plus (1 g/L) supplementation, each consisting of 4 replicate pens. Respiratory rate, water intake, feed intake, and live body weight were recorded weekly. At 49 days old, 12 birds per group were randomly selected, fasted for 12 h, weighed, and slaughtered for carcass evaluation and blood collection. The respiration rate of broilers decreased significantly (p < 0.01) with the terracotta drinker as compared to the plastic drinker. The water intake, the feed intake and the body weight gain increased significantly (p < 0.01) with the terracotta drinker as compared to the plastic drinker. The water addition of ASPRO‐C Plus significantly increased (p < 0.01) the relative weight of abdominal fat and spleen in broilers. The alpha‐amylase activity was significantly decreased (p < 0.01) with the water addition of ASPRO‐C Plus. The serum content of total cholesterol was significantly increased (p < 0.01) with the terracotta drinker. It can be concluded that ASPRO‐C Plus can slightly improve liveability, but using the terracotta drinker can be more efficient in reducing the behavioral response to heat stress and can improve the growth performance.
Organic BODIPY Based Gels: Optical, Electrochemical and Self‐Assembly Properties
Authors: Rao Ravulakollu Srinivasa , Rao G. Hanumantha , Venkateswararao Addanki , Nizamuddin Shaik , Narayanaswamy Kamatham , Singh Surya Prakash 
Published: November 2024

AbstractTwo novel BODIPY dyes, BOC3 and BC12, were synthesized with variable alkyl chains at terminal amide functional units. BC12, featuring a longer alkyl chain (−C12H25), formed a gel compared to BOC3, which has a shorter alkyl chain (< C‐>CH2OCH3), due to supra molecular self‐assembly in film. Both dyes exhibited absorption peaks around 530 nm in the visible region, with a red shift of about 30 nm in the film state, essential for organic electronic applications. Concentration variation studies revealed π‐π stacking/aggregates in the solid state causing red shifts in absorption and emission. BC12 exhibited more significant red shifts in film compared to its solution state due to supra molecular self‐assembly. Electronic structure analysis using density functional theories (BMK and O3LYP) showed better correlation with absorption using the O3LYP method. Both dyes displayed quasi‐irreversible oxidation and reduction couples with suitable HOMO (5.46 eV) and LUMO (3.32 eV) energy levels for organic electronic applications. Transient photoluminescence studies indicated a longer lifetime for BC12 (5.28 ns) than BOC3 (4.50 ns), suggesting π‐π aggregation and supra molecular self‐assembly. BC12′s gelation, attributed to its long alkyl chain and two‐dimensional motifs of the BODIPY core, forms spherical‐shaped nano networks. These findings underscore the potential of molecularly tuned dyes with alkyl chains for nano‐sized self‐assembly in organic electronic devices. Red shifts were observed due to combination of aggregation, stacking and columnar meso‐phase formation in supramolecular assembly. Absorption spectra of dyes in toluene with various concentrations showed the formation of Aggregation/π‐π stacking might be due to head to tailing interactions.
Manipulating Intramolecular Charge Transfer in Terpyridine Derivatives Towards “Turn‐On” Fluorescence Chemosensors for Zn2+
Authors: Zhao Qian , Li Lijun , Bi Dongqin , Wang Hongwei , Liu Datai , Wei Yuping , Xing Xiaojing , Yang Chunxia , Qiu Dongfang , Zhou Gang 
Published: November 2024

AbstractA series of donor‐acceptor (D−A) terpyridine derivatives with various intramolecular charge transfer interactions have been successfully synthesized bearing phenyl, methoxyphenyl, N‐butyldiphenylamine (DPA), and triphenylamine (TPA) as electron‐donors and terpyridine (TPY), 2,6‐di(pyrazin‐2‐yl)pyridine (PYDPZ), and N,N‐dimethylated PYDPZ (PYDPZ‐2CH3) as electron acceptors. Upon the introduction of pyrazine rings instead of pyridine ones and further selective N,N’‐dimethylation, the intramolecular D−A interactions are significantly enhanced, resulting in the remarkable reduced intramolecular charge transfer (ICT) transitions and quenched PL emissions in CH2Cl2 solution. However, their ICT emissions are clearly recovered upon adding Zn2+. Especially, for double positively charged compound 12, the Zn2+‐induced “turn‐on” green emission (λmax, em=518 nm, Φ=0.24) with excellent sensitivity (I/I0=77) and selectivity (IZn/ICd=23) is detected. Under the optimized experimental condition (EtOH‐H2O (9 : 1, v/v), containing 0.05 M HEPES buffer (pH=7.4)), this probe is used to quantitative determination of Zn2+ in a water sample with an average recovery of 97.5 %. Furthermore, the probe is applied to imaging of Zn2+ ions in HeLa cells and its mechanism is confirmed by the molecular dynamics simulation, in which lower coulomb potential for membrane surface adsorption and energy barrier for membrane translocation can be found.
The silver lining of parental migration on left‐behind adolescents' academic well‐being in China: A systematic review
Authors: Tadesse Endale , Gao Chunhai , Khalid Sabika 
Published: November 2024

AbstractThe well‐being, particularly academic performance, of left‐behind children (LBC) by their migrant parents has been studied. Although extensive literature pronounces the adverse impact of parental migration on LBC's academic outcomes, a growing body of evidence has found that these children might perform equally or even better academically than non‐left‐behind children (NLBC), which inspires the present review. This innovative study has systematically reviewed previous studies to provide evidence of a silver lining for parental migration and its implications. We searched for relevant studies from reliable sources and screened them between January and April 2023, following the PRISMA guidelines. After two authors independently screened the title, abstract and full text, 11 potential studies that met the inclusion/exclusion criteria were reviewed. The results indicate that eight eligible studies found no significant difference in academic performance between LBC and NLBC, while the remaining studies showed that LBC outperformed NLBC. Additionally, the age of left‐behind children, the duration and reasons for parental migration and household remittance practices were key factors in determining the resilience of LBCs towards academic engagement and performance. The present review findings suggest that future studies need to examine the positive consequence of parental migration on LBCs' academic and nonacademic outcomes by performing rigorous and robust methodology that unfolds and provides casual relationships, which insist on feasible practical and policy effective implications.
Design, Synthesis, Anticancer Evaluation and In Silico Studies of Imidazole Pyrazine Compounds
Authors: Chen Gong , Li Weiwei , Liu Yuanhui , Li Tong , Zhu Wenrun , Liu Ying , Jin Xiaobao , Mei Qinghua , Ye Lianbao 
Published: November 2024

AbstractThe present study focused on design and synthesis novel imidazolopyrazine derivatives, investigate the effect of them on the proliferation and migration of several human cancer cell lines by CCK‐8 method, and interactions with the JAKs by reverse molecular docking. It was found that most of the synthesized imidazolopyrazin derivatives exhibited excellent inhibitory effects towards three tested tutor cells in vitro. Among them, three compounds have IC50 values much lower than Fluorouracil while show low toxicity to normal cells L‐02. The migration ability assay have proved that A6 and A9 effectively inhibit the migration of tumor cells. Reverse molecular docking studies indicated that the potent targets of these derivatives are JAKs as they well docked into kinases with low energy. These finding suggest that imidazo[1,5‐a]pyrazin derivatives may be lead compounds for developing potent JAK targeted anticancer candidates.
Host‐Guest Interactions Facilitated by Chalcogen Bonding within Selenadiazole Functionalised Porphyrin Nanotubes
Authors: Thomson Catriona , Sani Marc‐Antoine , White Keith F. , Abrahams Brendan F. , White Jonathan M. 
Published: November 2024

AbstractThe structural rigidity of tetrakis(4‐pyridyl)porphyrin (TPyP) has been utilised to prepare a robust novel porous coordination polymer of composition Cd2(TPyP)(sez)2 (TPyP=5,10,15,20‐tetra(4‐pyridyl)porphyrin, sez=1,2,5‐benzoselenadiazole‐5‐carboxylate). The coordination polymer may be described as a hexagonal porphyrin nanotube (PNT) and has the potential to bind guest molecules through chalcogen bonding. Single crystal X‐ray diffraction (SCXRD) data indicate an internal pore diameter ~9 Å which represents ~35 % of the crystal volume. Immersion of the PNTs in solvents such as DMSO and CS2 result in the incorporation of these molecules within the nanotubes with chalcogen bonding between host and guest. The crystallographic guest‐inclusion investigations are complemented by solid‐state 77Se, 13C, 113Cd and 2H NMR studies which provide insights into dynamic behaviour. The porosity of the crystals was further explored using gas adsorption experiments, indicating the reversible uptake of CO2, CH4, H2 and N2. Structure‐function relationships are clearly established from complementary crystallographic, NMR and adsorption investigations.