bluuebunny/crossref_metadata_2025_split huggingface dataset:
Un cadre aménagé pour accueillir la souffrance : groupe expérientiel en Nouvelle-Calédonie… avec des filles-mères kanak
Authors: Wamo Albert , Tisserant Bernard 
Published: August 2018

La clinique décrite par les auteurs de cet article, psychologues à l’Aide sociale à l’enfance, expérimente un dispositif qui rassemble un groupe de filles-mères célibataires kanak de Nouvelle-Calédonie et une équipe pluridisciplinaire. Pour recueillir et traiter les souffrances traumatiques, celui-ci propose trois axes de travail : un espace de rencontres ritualisées par des expériences sensorielles, une adaptation de l’objet médiation Photolangage © aux résonances spécifiques de l’altérité et enfin une posture professionnelle associant bienveillance et respect. Il explore les liens avec la terre, le prénom kanak et l’oncle utérin. Avec le bouleversement des repères, ces liens peuvent assurer une fonction tantôt structurante étayée sur la transmission des valeurs familiales, tantôt déstructurante quand elle s’appuie sur des secrets et vides destructeurs.
IRAK1 Limits TLR3/4- and IFNAR-Driven IL-27 Production through a STAT1-Dependent Mechanism
Authors: Bruni Daniela , Dignam Adam , Dunne Susan , Wall-Coughlan Devlin , McCrudden Aisling , O’Connell Karen , Lyons Caitriona , McGuigan Christopher , Tubridy Niall , Butler Marion P. 
Published: August 2018

Abstract
IL-27 is a cytokine exerting pleiotropic immunomodulatory effects on a broad spectrum of immune cells. Optimal IL-27 production downstream of TLR3/4 ligand stimulation relies on autocrine type I IFN signaling, defining a first and second phase in IL-27 production. This work shows that IL-1 receptor-associated kinase 1 (IRAK1) limits TLR3/4- and IFNAR-induced IL-27 production. At the mechanistic level, we identified IRAK1 as a novel regulator of STAT1, IRF1, and IRF9. We found hyperactivation of STAT1 together with increased nuclear levels of IRF1 and IRF9 in IRAK1-deficient murine macrophages compared with control cells following stimulation with LPS and poly(I:C). IRAK1-deficient human microglial cells showed higher basal levels of STAT1 and STAT2 compared with control cells. Blocking the kinase activity of TBK1/IKKε in IRAK1 knockdown human microglial cells reduced the high basal levels of STAT1/2, uncovering a TBK1/IKKε kinase–dependent mechanism controlling basal levels of STAT1/2. Stimulating IRAK1 knockdown human microglial cells with IFN-β led to increased IL-27p28 expression compared with control cells. In IRAK1-deficient murine macrophages, increased IL-27 levels were detected by ELISA following IFN-β stimulation compared with control macrophages together with increased nuclear levels of p-STAT1, IRF1, and IRF9. Treatment of wild-type and IRAK1-deficient murine macrophages with fludarabine similarly reduced TLR3/4-induced IL-27 cytokine levels. To our knowledge, this work represents the first report placing IRAK1 in the IFNAR pathway and identifies IRAK1 as an important regulator of STAT1, controlling IL-27 production downstream of TLR3/4 and IFNAR signaling pathways.
Differential Induction of IFN-α and Modulation of CD112 and CD54 Expression Govern the Magnitude of NK Cell IFN-γ Response to Influenza A Viruses
Authors: Kronstad Lisa M. , Seiler Christof , Vergara Rosemary , Holmes Susan P. , Blish Catherine A. 
Published: August 2018

Abstract
In human and murine studies, IFN-γ is a critical mediator immunity to influenza. IFN-γ production is critical for viral clearance and the development of adaptive immune responses, yet excessive production of IFN-γ and other cytokines as part of a cytokine storm is associated with poor outcomes of influenza infection in humans. As NK cells are the main population of lung innate immune cells capable of producing IFN-γ early in infection, we set out to identify the drivers of the human NK cell IFN-γ response to influenza A viruses. We found that influenza triggers NK cells to secrete IFN-γ in the absence of T cells and in a manner dependent upon signaling from both cytokines and receptor–ligand interactions. Further, we discovered that the pandemic A/California/07/2009 (H1N1) strain elicits a seven-fold greater IFN-γ response than other strains tested, including a seasonal A/Victoria/361/2011 (H3N2) strain. These differential responses were independent of memory NK cells. Instead, we discovered that the A/Victoria/361/2011 influenza strain suppresses the NK cell IFN-γ response by downregulating NK-activating ligands CD112 and CD54 and by repressing the type I IFN response in a viral replication–dependent manner. In contrast, the A/California/07/2009 strain fails to repress the type I IFN response or to downregulate CD54 and CD112 to the same extent, which leads to the enhanced NK cell IFN-γ response. Our results indicate that influenza implements a strain-specific mechanism governing NK cell production of IFN-γ and identifies a previously unrecognized influenza innate immune evasion strategy.
Investigating environmental management practices within the Northern Cape wine supply chain
Authors: Trollip Elize G. 
Published: August 2018

Background: Environmental management systems and practices have become a necessity in wine supply chains, given their vulnerability to climate change. Climate change could lead to a 55% loss of wine-cultivating land in South Africa by 2050, which would harm the first two tiers of the wine supply chain.Objectives: The objective was to investigate the current environmental systems and practices applied in the first two tiers of the Northern Cape wine supply chain.Method: This qualitative exploratory study was conducted by semi-structured interviews to determine the various environmental management systems and practices adopted by role players. The data collected were analysed by thematic analysis.Results: The results indicated the implementation of an environmental management tool, namely the Integrated Production of Wine scheme. Supportive practices such as water- and energy-wise approaches, soil management and waste management were also identified. Furthermore, a sincere relationship between farmers, cellars and viticulturists results in collaboration based on mutual information sharing and cooperation between role players to reduce their environmental impact.Conclusion: The various environmental management practices and the collaborative approach between role players can serve as an example to other agricultural supply chains.
Computed Tomography Evaluation of the Arterial Supply to Segment 4 of the Liver
Authors: Putta Tharani , John Reetu Amrita , Eapen Anu , Chandramohan Anuradha , Simon Betty , Rymbai Manbha L , Joseph Philip 
Published: August 2018

Introduction:
In a setting of living-donor liver transplant and patients undergoing extended hepatic resections for both primary and metastatic liver tumors, preoperative assessment of hepatic arterial anatomy is very important because of the risk of ischemic complications in the event of inadvertent injury to the arterial supply. Anatomical variations in hepatic arterial supply to the liver are very common and seen in nearly half the population. Identifying anomalous origin of segment 4 hepatic artery is vital since this vessel can cross the transection plane and can result in liver ischemia and liver failure. The purpose of our study is to study the variations in hepatic arterial anatomy to segment 4 of the liver in the Indian population.

Materials and Methods:
A retrospective evaluation of 637 consecutive computed tomography (CT) angiograms over a period of 1 year was performed, and we analyzed the arterial supply to segment 4 of the liver.

Results:
We found that the arterial supply to segment 4 of the liver originated from left hepatic artery (LHA) in majority of cases, 76.3%. LHA along with the accessory LHA supplied this segment in 6.4%, whereas the accessory LHA solely supplied this segment in 0.4%. The right hepatic artery (RHA) was seen to supply this segment in 10.2%. Dual supply with branches from the RHA and LHA was seen in 6.6% of patients.

Conclusion:
Preoperative mapping of segment 4 hepatic arterial supply using CT angiography will act as a roadmap to surgeons as they attempt to carefully dissect and preserve this segments' arterial supply. Depending on the anatomical variation, surgical techniques will vary to ensure safety of segment 4 arterial supply.
2010–2016 methane trends over Canada, the United States, and Mexico observed by the GOSAT satellite: contributions from different source sectors
Authors: Sheng Jian-Xiong , Jacob Daniel J. , Turner Alexander J. , Maasakkers Joannes D. , Benmergui Joshua , Bloom A. Anthony , Arndt Claudia , Gautam Ritesh , Zavala-Araiza Daniel , Boesch Hartmut , Parker Robert J. 
Published: August 2018

Abstract. We use 7 years (2010–2016) of methane column observations from the
Greenhouse Gases Observing Satellite (GOSAT) to examine trends in atmospheric
methane concentrations over North America and infer trends in emissions.
Local methane enhancements above background are diagnosed in the GOSAT data
on a 0.5∘×0.5∘ grid by estimating the local background as
the low (10th–25th) percentiles of the
deseasonalized frequency distributions of the data for individual years.
Trends in methane enhancements on the 0.5∘×0.5∘ grid are
then aggregated nationally and for individual source sectors, using
information from state-of-science bottom-up inventories. We find that US
methane emissions increased by 2.5±1.4  % a−1 (mean ± 1 standard deviation) over the 7-year period, with contributions from both
oil–gas systems (possibly unconventional oil–gas production) and from
livestock in the Midwest (possibly swine manure management). Mexican
emissions show a decrease that can be attributed to a decreasing cattle
population. Canadian emissions show year-to-year variability driven by
wetland emissions and correlated with wetland areal extent. The US emission
trends inferred from the GOSAT data account for about 20 % of the observed
increase in global methane over the 2010–2016 period.
Tropospheric sources and sinks of gas-phase acids in the Colorado Front Range
Authors: Mattila James M. , Brophy Patrick , Kirkland Jeffrey , Hall Samuel , Ullmann Kirk , Fischer Emily V. , Brown Steve , McDuffie Erin , Tevlin Alex , Farmer Delphine K. 
Published: August 2018

Abstract. We measured organic and inorganic gas-phase acids in the
Front Range of Colorado to better understand their tropospheric sources and
sinks using a high-resolution time-of-flight chemical ionization mass
spectrometer. Measurements were conducted from 4 to 13 August 2014 at the
Boulder Atmospheric Observatory during the Front Range Air Pollution and
Photochemistry Éxperiment. Diurnal increases in mixing ratios are
consistent with photochemical sources of HNO3, HNCO, formic, propionic,
butyric, valeric, and pyruvic acid. Vertical profiles taken on the 300 m
tower demonstrate net surface-level emissions of alkanoic acids, but net
surface deposition of HNO3 and pyruvic acid. The surface-level alkanoic
acid source persists through both day and night, and is thus not solely
photochemical. Reactions between O3 and organic surfaces may contribute
to the surface-level alkanoic acid source. Nearby traffic emissions and
agricultural activity are a primary source of propionic, butyric, and
valeric acids, and likely contribute photochemical precursors to HNO3
and HNCO. The combined diel and vertical profiles of the alkanoic acids and
HNCO are inconsistent with dry deposition and photochemical losses being the
only sinks, suggesting additional loss mechanisms.
GRP137 promotes cell proliferation and metastasis through regulation of the PI3K/AKT pathway in human ovarian cancer
Authors: Zhang Li-qian , Yang Su-qing , Qu Xiang-dong , Chen Xian-jun , Lu Hong-sheng , Wang Ying 
Published: August 2018

Purpose: Ovarian cancer is one of the leading causes of death for women worldwide. The present study aims to investigate the role of G protein-coupled receptor 137 (GPR137) in the biological activities of ovarian cancer cells. Methods: (QUERY: Please supply Methods for Abstract) Results: G protein-coupled receptor 137 was highly expressed in clinical ovarian cancer tissues and exhibited the highest protein levels in SKOV3 cells and OVCAR3 cells. Knockdown of GPR137 caused significant decreases in cell proliferative rates and colony formation abilities in SKOV3 cells and OVCAR3 cells and also inhibited the in vivo tumorigenesis in a xenograft model. It was observed that knockdown of GPR137 inhibited cell motility by up to 40% in SKOV3 cells and approximately 65% in OVCAR3 cells in wound-healing assay. Cell migration abilities were consistently inhibited by 68.2% in SKOV3 cells and 59.3% in OVCAR3 cells, whereas cell invasion abilities were inhibited by 64.0% and 74.2% in SKOV3 and OVCAR3 cells, respectively, after knockdown of GPR137. When GPR137 was depleted, epithelial markers were increased, while mesenchymal markers decreased. Conclusions: Our data suggest that GPR137 plays pro-oncogenic roles in ovarian cancer via regulation of the PI3K/AKT pathway. These observations might pave new insights into therapeutic strategies against human ovarian cancer.
Multicenter prospective study of angiogenesis polymorphism validation in HCC patients treated with sorafenib. An INNOVATE study protocol
Authors: Gardini Andrea Casadei , Faloppi Luca , Aprile Giuseppe , Brunetti Oronzo , Caparello Chiara , Corbelli Jody , Chessa Luchino , Bruno Daniele , Ercolani Giorgio , Leonetti Alessandro , Stefano Giorgio de , Farella Nunzia , Foschi Francesco Giuseppe , Lanzi Arianna , Dadduzio Vincenzo , Marisi Giorgia , Masi Gianluca , Negri Francesca V. , Pagan Flavia , Santini Daniele , Scarpi Emanuela , Silletta Marianna , Silvestris Nicola , Tamburini Emiliano , Tassinari Davide , Vivaldi Caterina , Gentilucci Umberto Vespasiani , Zagonel Vittorina , Calvetti Lorenzo , Cascinu Stefano , Frassineti Giovanni Luca , Scartozzi Mario 
Published: August 2018

Introduction: Although sorafenib is the upfront standard of care for advanced hepatocellular carcinoma (HCC), molecular predictors of efficacy have not been identified yet. In the ALICE-1 study, rs2010963 of VEGF-A and VEGF-C proved to be independent predictive factors for progression-free survival (PFS) and overall survival (OS) in multivariate analysis. The ALICE-1 study results were confirmed in the ALICE-2 study, in which VEGF and VEGFR SNPs were analyzed. In the ePHAS study we analyzed the SNPs of eNOS. In univariate analysis, patients homozygous for an eNOS haplotype (HT1: T-4b at eNOS-786/eNOS VNTR) had significantly shorter median PFS and OS than those with other haplotypes. These data were confirmed in the validation set. Methods: This nonpharmacological, interventional, prospective multicenter study aims to determine whether eNOS, HIF-1, VEGF, Ang2 and VEGFR polymorphisms play a role in predicting the objective response rate, PFS, and OS of advanced HCC patients treated with sorafenib. The study will involve 160 advanced HCC patients with Child-Pugh class A disease. The primary aim is to validate the prognostic or predictive roles of eNOS, Ang2, HIF-1, VEGF and VEGFR polymorphisms in relation to the clinical outcome (PFS) of HCC patients treated with sorafenib. Conclusions: Overall, our data may suggest that polymorphism analysis of the VEGF, VEGFR-2, HIF and eNOS genes can identify HCC patients who are more likely to benefit from sorafenib.
A Brief Background on Cannabis: From Plant to Medical Indications
Authors: Klumpers Linda E , Thacker David L 
Published: August 2018

Abstract
Cannabis has been used as a medicinal plant for thousands of years. As a result of centuries of breeding and selection, there are now over 700 varieties of cannabis that contain hundreds of compounds, including cannabinoids and terpenes. Cannabinoids are fatty compounds that are the main biological active constituents of cannabis. Terpenes are volatile compounds that occur in many plants and have distinct odors. Cannabinoids exert their effect on the body by binding to receptors, specifically cannabinoid receptors types 1 and 2. These receptors, together with endogenous cannabinoids and the systems for synthesis, transport, and degradation, are called the Endocannabinoid System. The two most prevalent and commonly known cannabinoids in the cannabis plant are delta-9-tetrahydrocannabinol (THC) and cannabidiol. The speed, strength, and type of effects of cannabis vary based on the route of administration. THC is rapidly distributed through the body to fatty tissues like the brain and is metabolized by the cytochrome P450 system to 11-hydroxy-THC, which is also psychoactive. Cannabis and cannabinoids have been indicated for several medical conditions. There is evidence of efficacy in the symptomatic treatment of nausea and vomiting, pain, insomnia, post-traumatic stress disorder, anxiety, loss of appetite, Tourette’s syndrome, and epilepsy. Cannabis has also been associated with treatment for glaucoma, Huntington’s Disease, Parkinson’s Disease, and dystonia, but there is not good evidence to support its efficacy. Side effects of cannabis include psychosis and anxiety, which can be severe. Here, we provided a summary of the history of cannabis, its pharmacology, and its medical uses.
Educação especial e educação de jovens e adultos: uma interface em construção?
Authors: Cabral Rosângela Martins , Bianchini Luciane Guimarães Batistella , Gonçalves Taisa Grasiela Gomes Liduenha 
Published: August 2018

A Educação Especial (EE) e a Educação de Jovens e Adultos (EJA) apresentam semelhanças históricas de negação ao direito educacional e, recentemente, essas duas áreas têm se deparado com encontros e desafios. A partir dessa ideia questionamos: como vem sendo construída a EJA para os alunos da EE? Por meio de uma pesquisa qualitativa e quantitativa com análise bibliométrica, o presente estudo objetivou verificar se a produção acadêmica brasileira tem discutido essa temática. Também buscou identificar a percepção do processo de escolarização na EJA Especial por dois alunos com deficiência intelectual e física, estudantes de uma escola estadual paranaense, através de uma entrevista semiestruturada. Os resultados revelaram como pouco expressivo o número de trabalhos sobre o tema, que totalizaram quatorze, no período de 2010 a 2016. Com relação às percepções dos alunos sobre sua trajetória escolar, eles destacaram que a visão orgânica e assistencialista, seja da família ou da escola, prevalece sobre suas reais possibilidades. Concluiu-se que a interface entre EE e EJA continua apresentando reflexões sobre a efetividade das políticas, das interações sociais e das práticas inclusivas.
Stacking Effects in van der Waals Heterostructures of Silicene and Hexagonal Boron Nitride
Authors: Sattar Shahid , Zhang Yongyou , Schwingenschlögl Udo 
Published: August 2018

AbstractThe stacking effects on the electronic structure of van der Waals heterostructures consisting of silicene and hexagonal boron nitride are investigated by first‐principles calculations. It is shown that the stacking is fundamental for the details of the dispersion relation in the vicinity of the Fermi energy (gapped, non‐gapped, linear, parabolic) despite small differences in the total energy. It is also demonstrated that the tight‐binding model of bilayer graphene is able to capture most of these features of the van der Waals heterostructures, and the limitations of the model are identified.
Biocatalytic Synthesis of Chiral N‐Functionalized Amino Acids
Authors: Hyslop Julia F. , Lovelock Sarah L. , Sutton Peter W. , Brown Kristin K. , Watson Allan J. B. , Roiban Gheorghe‐Doru 
Published: August 2018

AbstractN‐Functionalized amino acids are important building blocks for the preparation of diverse bioactive molecules, including peptides. The development of sustainable manufacturing routes to chiral N‐alkylated amino acids remains a significant challenge in the pharmaceutical and fine‐chemical industries. Herein we report the discovery of a structurally diverse panel of biocatalysts which catalyze the asymmetric synthesis of N‐alkyl amino acids through the reductive coupling of ketones and amines. Reactions have been performed on a gram scale to yield optically pure N‐alkyl‐functionalized products in high yields.
Visible‐Light‐Driven Overall Water Splitting Boosted by Tetrahedrally Coordinated Blende Cobalt(II) Oxide Atomic Layers
Authors: Xu Jiaqi , Li Xiaodong , Ju Zhengyu , Sun Yongfu , Jiao Xingchen , Wu Ju , Wang Chengming , Yan Wensheng , Ju Huanxin , Zhu Junfa , Xie Yi 
Published: August 2018

AbstractDirectly splitting water into H2 and O2 with solar light is extremely important; however, the overall efficiency of water splitting still remains extremely low. Two types of ultrathin semiconductor layers with the same elements and the same thicknesses were designed to uncover how different atomic arrangements influence water‐splitting efficiency thermodynamically and kinetically. As an example, tetrahedrally coordinated blende and octahedrally coordinated rocksalt CoO atomic layers with nearly the same thicknesses were synthesized for the first time. The blende CoO atomic layers have a smaller Eg and abundant d–d internal transition features relative to the rocksalt CoO atomic layers, which ensure enhanced visible‐light harvesting ability. Density functional theory calculations reveal that the Bader charge for Co atoms in blende CoO atomic layers is larger than that of the rocksalt CoO atomic layers, which facilitates photocarrier transfer kinetics, as verified by photoluminescence spectra and time‐resolved fluorescence emission decay spectra. In situ FTIR spectra and energy calculations reveal that the *OOH dissociation step is the rate‐limiting step, where the blende CoO atomic layers possess a smaller *OOH dissociation energy thanks to their higher Bader charge and stronger steric effect, as confirmed by the elongated Co−OOH bonds. The blende CoO atomic layers exhibit visible‐light‐driven H2 and O2 formation rates of 4.43 and 2.63 μmol g−1 h−1, roughly 3.7 times higher than those of the rocksalt CoO atomic layers.
Design Rules for Self‐Assembly of 2D Nanocrystal/Metal–Organic Framework Superstructures
Authors: Qiu Fen , Edison John R. , Preisler Zdenek , Zhang Yan‐Fang , Li Guo , Pan Aizhao , Hsu Chih‐Hao , Mattox Tracy M. , Ercius Peter , Song Chengyu , Bustillo Karen , Brady Michael A. , Zaia Edmond W. , Jeong Sohee , Neaton Jeffrey B. , Du Shixuan , Whitelam Stephen , Urban Jeffrey J. 
Published: August 2018

AbstractWe demonstrate the guiding principles behind simple two dimensional self‐assembly of MOF nanoparticles (NPs) and oleic acid capped iron oxide (Fe3O4) NCs into a uniform two‐dimensional bi‐layered superstructure. This self‐assembly process can be controlled by the energy of ligand–ligand interactions between surface ligands on Fe3O4 NCs and Zr6O4(OH)4(fumarate)6 MOF NPs. Scanning transmission electron microscopy (TEM)/energy‐dispersive X‐ray spectroscopy and TEM tomography confirm the hierarchical co‐assembly of Fe3O4 NCs with MOF NPs as ligand energies are manipulated to promote facile diffusion of the smaller NCs. First‐principles calculations and event‐driven molecular dynamics simulations indicate that the observed patterns are dictated by combination of ligand–surface and ligand–ligand interactions. This study opens a new avenue for design and self‐assembly of MOFs and NCs into high surface area assemblies, mimicking the structure of supported catalyst architectures, and provides a thorough fundamental understanding of the self‐assembly process, which could be a guide for designing functional materials with desired structure.