bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of thermodynamic equations of state across chemistry and structure in the materials project
Authors: Latimer Katherine , Dwaraknath Shyam , Mathew Kiran , Winston Donald , Persson Kristin A. 
Published: July 2018

AbstractThermodynamic equations of state (EOS) for crystalline solids describe material behaviors under changes in pressure, volume, entropy and temperature, making them fundamental to scientific research in a wide range of fields including geophysics, energy storage and development of novel materials. Despite over a century of theoretical development and experimental testing of energy–volume (E–V) EOS for solids, there is still a lack of consensus with regard to which equation is indeed optimal, as well as to what metric is most appropriate for making this judgment. In this study, several metrics were used to evaluate quality of fit for 8 different EOS across 87 elements and over 100 compounds which appear in the literature. Our findings do not indicate a clear “best” EOS, but we identify three which consistently perform well relative to the rest of the set. Furthermore, we find that for the aggregate data set, the RMSrD is not strongly correlated with the nature of the compound, e.g., whether it is a metal, insulator, or semiconductor, nor the bulk modulus for any of the EOS, indicating that a single equation can be used across a broad range of classes of materials.
Toll-Like Receptor 4 (TLR4) Expression Affects Schwann Cell Behavior in vitro
Authors: Zhang Huanhuan , Shao Zhiwei , Zhu Yun , Shi Lingyu , Li Zhihao , Hou Rui , Zhang Chunwang , Yao Dengbing 
Published: July 2018

AbstractPeripheral nerve injury can result in the decreased quality of life and bring us economic burden on society and individuals. Wallerian degeneration (WD) is critical for nerve degeneration and regeneration, but the mechanisms of WD are still elusive. Here, we report the effect of Toll-like receptor 4 (TLR4) on cultured Schwann cells (SCs) in vitro. The data showed that TLR4 expression was up-regulated after sciatic nerve injury of rat. TLR4 was expressed in cultured SCs. Enhanced or silenced expression of TLR4 affected SC proliferation, migration, apoptosis and relative gene expression. Furthermore, altered expression of TLR4 resulted in expression changes in c-Jun, ERK and catenin but not AKT and c-Fos pathways in SCs. These results suggested that TLR4 may be an important effective target in peripheral nerve degeneration and/or regeneration during WD in future investigations.
Frequency and pattern of exercise and depression after two years in older Japanese adults: the JAGES longitudinal study
Authors: Kanamori Satoru , Takamiya Tomoko , Inoue Shigeru , Kai Yuko , Tsuji Taishi , Kondo Katsunori 
Published: July 2018

AbstractFew have clarified what exercise frequencies and patterns (e.g. alone or with others) are effective for preventing depression in older adults. We examined the relationship between total frequency and/or pattern of exercise and the risk of depression after two years in older Japanese adults. We used a sub-sample of the Japan Gerontological Evaluation Study (JAGES) performed in 2011 and 2013. The sample for analysis was 1,422 adults aged 65 years or older without depression and low physical strength in 2011. All variables were assessed with a questionnaire including the geriatric depression screening scale (GDS-15). Binomial logistic regression analysis was used to examine the relationships between exercise in 2011 and depression in 2013 (0 = non-depression, 1 = depression). The adjusted odds ratio (OR) for later depression was 0.52 (95% confidence intervals: 0.33–0.81) for exercise two or more times a week compared to non-exercisers. The OR for exercisers who exercise with others even a little (Ewo) was 0.53 (0.34–0.84) compared to non-exercisers. Among combinations of frequency and pattern, the OR for Ewo who exercise two or more times a week was 0.40 (0.24–0.68) compared to non-exercisers. Exercising at least twice a week and/or with others may be useful in preventing depression in older adults.
Sentinel nurseries to assess the phytosanitary risks from insect pests on importations of live plants
Authors: Kenis Marc , Li Hongmei , Fan Jian-ting , Courtial Beatrice , Auger-Rozenberg Marie-Anne , Yart Annie , Eschen René , Roques Alain 
Published: July 2018

AbstractOrnamental plants represent a major pathway of invasion for alien pests worldwide. Commodity risk analyses are carried out to assess the risk posed by a new trade in a commodity, but they are restricted by our limited knowledge of the pests carried by traded plants. We used the sentinel nursery technique to identify insects attacking woody plants imported into Europe. We established two sentinel nurseries in China, with five traded Asian plants. These nurseries were monitored for two years to obtain lists of insects that can be expected on these commodities. These records were compared with those obtained from literature surveys, which are usually the sources of information available to pest risk assessors. At each site, 105 insect species and host associations were found on sentinel plants and 90% of these associations had not been found in a previous literature survey of insect pests of the five plants. Nearly 80% of these associations were not found in ana posterioriliterature survey. An assessment classified 9%, 7% and 84% of the insect records as presenting a high, moderate and low likelihood of introduction, respectively. These results show the benefit of sentinel nurseries to identify potential infestation of plant commodity imports.
Novel 3D Structure Based Model for Activity Prediction and Design of Antimicrobial Peptides
Authors: Liu Shicai , Bao Jingxiao , Lao Xingzhen , Zheng Heng 
Published: July 2018

AbstractThe emergence and worldwide spread of multi-drug resistant bacteria makes an urgent challenge for the development of novel antibacterial agents. A perspective weapon to fight against severe infections caused by drug-resistant microorganisms is antimicrobial peptides (AMPs). AMPs are a diverse class of naturally occurring molecules that are produced as a first line of defense by all multi-cellular organisms. Limited by the number of experimental determinate 3D structure, most of the prediction or classification methods of AMPs were based on 2D descriptors, including sequence, amino acid composition, peptide net charge, hydrophobicity, amphiphilic, etc. Due to the rapid development of structural simulation methods, predicted models of proteins (or peptides) have been successfully applied in structure based drug design, for example as targets of virtual ligand screening. Here, we establish the activity prediction model based on the predicted 3D structure of AMPs molecule. To our knowledge, it is the first report of prediction method based on 3D descriptors of AMPs. Novel AMPs were designed by using the model, and their antibacterial effect was measured by in vitro experiments.
Surface plasmon resonance based sensor for the detection of glycopeptide antibiotics in milk using rationally designed nanoMIPs
Authors: Altintas Zeynep 
Published: July 2018

AbstractGlycopeptide antibiotics are known as the last resort for the treatment of serious infections caused by Gram-positive bacteria. The use of milk products contaminated with these antibiotic residues leads to allergic reactions and sensitivity in human. Also, long-term consumption of milk products containing low levels of these antibiotics may cause the relevant bacteria to build up resistance to these last resort antibiotics. Sensitive, rapid and effective quantification and monitoring systems play a key role for their determination in milk products. Hence, molecularly imprinted nanostructures were rationally designed in this work to produce high affinity synthetic receptors to be coupled with a surface plasmon resonance sensor for the analysis of glycopeptide antibiotics in milk samples. The nanoMIP-SPR sensor enabled vancomycin quantification with the LODs of 4.1 ng mL−1 and 17.7 ng mL−1 using direct and competitive assays, respectively. The recoveries rates for two sensor methods ranged in 85–110% with RSDs below 7%. The affinity between the nanoMIP receptors and the target molecule (dissociation constant: 1.8 × 10−9 M) is mostly superior to natural receptors and other synthetic receptors. Unlike other methods commonly employed for the detection of milk contaminants this approach is extremely simple, fast and robust, and do not require pre-sample treatment.
Effects of Threat Conditioning on the Negative Valanced Systems and Cognitive Systems
Authors: Fernández Rodrigo S. , Picco Soledad , Messore Fernando , Pedreira María E. 
Published: July 2018

AbstractThreat conditioning is held as a model of anxiety disorders. However, this approach is focused on implicit responses evaluated in a single day. Here, we evaluated negative-valence, positive-valence and cognitive-systems in order to evaluate the extent to which threat conditioning models anxiety disorders. Subjects underwent threat conditioning and five-minutes (Short-term evaluation) or 48 hs (Long-term evaluation) later, both groups performed several tasks targeting cognitive-systems and valenced-systems. In the short-term evaluation, successful conditioning maintained state-anxiety and increased the aversiveness representation of the CS+ and the valuation for negative events. Reaction-times for the CS+ were faster, reflecting an attentional bias toward threat. In the long-term evaluation, participants represented the CS+ as more aversive and generalized to all stimuli. Reaction-times showed a more restricted attentional bias. Threat conditioning alters the negative-valence systems and creates a cognitive bias, which is transformed by memory consolidation, suggesting that this protocol could be a useful resource to understand the deficits associated with anxiety disorders.
Innovative Lehrmethoden: Einsatz eines ophthalmochirurgischen Wetlabs im Studentenunterricht
Authors: Enders Christian , Schneider Achim , Keis Oliver , Grab-Kroll Claudia , Loidl Max , Kampmeier Jürgen , Lang Gerhard K. , Werner Jens Ulrich 
Published: July 2018

Zusammenfassung
Hintergrund Ein erhöhter Bedarf an ärztlichem Nachwuchs in Deutschland führt dazu, dass der Wettbewerb um die besten Köpfe schon während des Studiums beginnt. Daher ist es Aufgabe der Universitätskliniken, ihren Studierenden bestmögliche Lehrveranstaltungen anzubieten, um Interesse am jeweiligen Fachgebiet zu wecken. Wir überprüften deshalb den Einfluss eines ophthalmochirurgischen Wetlabs auf die Lehre im Rahmen des klinischen Studienabschnitts.
Material/Methoden Im Rahmen der Intensivwoche Augenheilkunde an unserer Universitätsklinik wurde den Studierenden die freiwillige Teilnahme an dem ophthalmochirurgischen Wetlab angeboten. Zu Beginn und am Ende der Intensivwoche sowie am Ende des Wetlabs beantworteten die Studierenden Fragebögen mit Fragen zum Interesse an dem Fachgebiet Augenheilkunde sowie der konkreten Bewertung des Wetlabs.
Ergebnisse Das Interesse der Studierenden an der Augenheilkunde konnte durch die Intensivwoche und zusätzlich durch das Wetlab gesteigert werden. Das Wetlab bereicherte die Intensivwoche und wurde von den Teilnehmenden mit der Schulnote 1,12 bewertet. Die Gesamtbewertung der Intensivwoche war unter Teilnehmenden des Wetlabs signifikant besser als in der Gruppe ohne Wetlab-Teilnahme. Das Wetlab bereitete den Studierenden große Freude, ermöglichte das Anwenden des theoretisch erworbenen Wissens, erlaubte wertvolle Einblicke in das Fach Augenheilkunde und war problemlos umsetzbar.
Schlussfolgerung Die Integration eines Wetlabs in die Lehre im klinischen Studienabschnitt wird von den Studierenden sehr positiv bewertet und ermöglicht diesen einen wertvollen Einblick in das Fachgebiet Augenheilkunde sowie in das Berufsfeld des Augenarztes.
Radical-type Reactions Controlled by Cobalt: From Carbene Radical Reactivity to the Catalytic Intermediacy of Reactive o-Quinodimethanes
Authors: de Bruin Bas , te Grotenhuis Colet 
Published: July 2018

In this account, we summarize our recent efforts in the fields of ‘open-shell organometallic chemistry’ and ‘metalloradical catalysis’. We focus in particular on the use of so-called ‘carbene radicals’ for the synthesis of a variety of useful synthons for organic chemistry. We further show that unexpected reactivity arises from catalytic synthesis of unusual o-quinone methide and o-quinodimethane intermediates that undergo subsequent rearrangements to uncommon products.1	Introduction2	General (Fischer-Type) Carbene and Nitrene Reactivity and Their Relation to Carbene and Nitrene Radical Reactivity3	Carbene and Nitrene (Radical) Precursors4	Formation and Intrinsic Radical-Type Reactivity of Carbene and Nitrene Radicals5	Types of Cobalt Catalysts Used in Reactions Involving Carbene and Nitrene Radicals6	Applications of Cobalt-Catalyzed Ring-Closure Reactions via ­Carbene Radicals7	Intermediacy of o-Quinone Methide and o-Quidodimethanes in Carbene Ring-Closing Reactions8	Conclusion
Diversity of Glycoprotein Deficiencies in Glanzmann’s Thrombasthenia
Authors: Meyer M , Herrmann F H 
Published: July 2018

SummaryThe platelet proteins of 9 thrombasthenic patients from 7 families were analysed by high resolution two-dimensional gel electrophoresis (HR-2DE) and crossed immunoelectrophoresis (CIE). In 7 patients both glycoproteins (GPs) IIb and Ilia were absent or reduced to roughly the same extent. In two related patients only a trace of GP Ilb-IIIa complex was detected in CIE, but HR-2DE revealed a glycopeptide in the position of GP Ilia in an amount comparable to type II thrombasthenia. This GP Ilia-like component was neither recognized normally by anti-GP Ilb-IIIa antibodies nor labeled by surface iodination. In unreduced-reduced two-dimensional gel electrophoresis two components were observed in the region of GP Ilia. The assumption of a structural variant of GP Ilia in the two related patients is discussed.
Turnover Study of Heparin Cofactor II in Healthy Man
Authors: Sié P , Dopouy D , Pichon J , Boneu B 
Published: July 2018

SummaryHeparin cofactor II (HC II) is a heparin-dependent inhibitor of thrombin, distinct from antithrombin III (AT III). This study was designed to evaluate its metabolism in healthy subjects. Purified HC II was labelled with 125I by the lactoperoxidase-glucose oxidase technique. The biological activity of the HC II was unchanged after labelling as was its migratory pattern by crossed immunoelectrophoresis in the presence of heparin or dermatan sulfate.Three healthy volunteers were injected with 10 uCi and the plasma radioactivity was measured daily. The data were approximated by a sum of two exponential terms and the metabolism of HC II was described by a two compartment mamillary system.The mean values of fractional catabolic rate, intravascular fraction and half-life of the elimination phase were respectively: 0.44 d-1, 0.60 and 2.53 d. These parameters are of the same order of magnitude as those reported in the literature for AT III. The plasma HC II concentration in the 3 subjects ranged from 61 to 82 ug/ml as estimated using our purified preparation. Accordingly, the absolute catabolic rate ranged from 1.17 to 1.36 mg · kg-1 · d-1.
Effect of Dextran on Factor Vlll/von Willebrand Factor Structure and Function
Authors: Batlle J , del Río F , López Fernández M F , Martín R , López Borrasca A 
Published: July 2018

SummaryFactor VIII/von Willebrand factor was analyzed before and after the infusion of 500 ml of Dextran 70 to normal volunteers. Factor VIII procoagulant activity, factor VIII related antigen and ristocetin cofactor activity showed a significant decrease, reaching after six hours the minimum level, which did not correlate with the hemodilution effect caused by dextran. Ristocetin-induced platelet agglutination (RIPA) in volunteers’ platelet-rich plasma (PRP) did not show any significant change between preinfusion time and six hours after the infusion. Multimeric analysis of von Willebrand factor (vWF) showed a progressive decrease of all the multimers which was more pronounced in the largest multimers. No change was seen in the “triplet” structure of vWF. No effect was noticed when dextran was incubated “in vitro” either with PRP or platelet-poor plasma. The modification induced by dextran is close to the pattern seen in subtype Ib von Willebrand’s disease.
The Dilute Phospholipid APTT: A Sensitive Assay for Verification of Lupus Anticoagulants
Authors: Alving Barbara M , Baldwin Phillip E , Richards Roberta L , Jackson Beverly J 
Published: July 2018

SummaryA simple sensitive method for verification of lupus anticoagulants utilizing dilution of phospholipid in the activated partial thromboplastin time (APTT) system is described. Patient plasma, mixed with an equal volume of normal plasma, is activated with micronized silica. To this mixture are added different dilutions of Thrombofax® and then calcium chloride. Clotting times are plotted linearly against the logarithm of the phospholipid dilutions and slopes are calculated by regression analysis. In this assay the mean negative slope of 19 plasmas that contained antiphospholipid activity was five times greater than those of normal plasma or those obtained from patients having single or multiple coagulation factor deficiencies such as those induced by warfarin. The assay can be modified to test heparinized plasmas. Thus, it is a sensitive means by which to verify the presence of lupus anticoagulants in patients who have congenital or acquired factor deficiencies or who are receiving anticoagulant therapy.
Management of Haemophilia A with Antibodies - The Effect of Combined Treatment with Factor VIII, Hydrocortisone and Cyclophosphamide
Authors: Hedner U , Tengborn L 
Published: July 2018

SummaryImmune tolerance has by several methods been induced in
haemophiliacs with antibodies. A conversion of “high responders” into “low responders” was previously reported after repeated moderate factor IX doses over periods of 7-10 days in
combination with cyclophosphamide and steroids in two patients with haemophilia B and inhibitors. This paper reports similar results in a heamophilia A patient by giving factor VIII, cyclophosphamide, and steroids during relatively short periods of time (7-8 days). The anamnestic response markedly decreased already following the first treatment and never exceeded a level of 1 u/ml (˜ 3 BU/ml) even when boosted with ordinary factor VIII doses for only 3 days. It is concluded that the markedly decreased secondary antibody response is most probably the result of factor VIII given at short intervals (twice a day) for periods of up to about one week when given in combination with cyclophosphamide and steroids. The same effect may be achieved by other methods. The treatment schedule suggested in the present paper is, however, simple and avoids long periods of high antibody levels. Furthermore, the total factor VIII dose used is lower than suggested in most other treatment schedules, which makes the treatment substantially less expensive.
Effect of Imidazoline Drugs on Human Blood Platelet Aggregation
Authors: Petrusewicz Jacek , Kaliszan Roman 
Published: July 2018

SummaryThe effect of seven commonly used in therapy imidazoline derivatives on human blood platelet aggregation was studied. Three of the agents, i.e. clonidine, antazoline and tetryzoline were classified as partial agonists of the receptor responsible for aggregation. Two other drugs, i.e. phentolamine and tolazoline act as competitive antagonists of relatively high receptor affinity. The remaining imidazolines: xylometazoline and naphazoline effectively inhibit the platelet receptor in a non-competitive manner. The last two compounds seem to be selective alpha2-adrenoceptor antagonists.
Effects of Ticlopidine of Platelet Function in Men with Stable Angina Pectoris
Authors: Berglund Ulf , Schenck Henning von , Wallentin Lars 
Published: July 2018

SummaryThe effects of ticlopidine (T) (500 mg daily) on platelet function were investigated in a double-blind placebo-controlled study in 38 middle-aged men with stable incapacitating angina pectoris. The in vitro platelet reactivity to aggregating agents, the platelet sensitivity to prostacyclin and the plasma levels of platelet specific proteins and fibrinogen were determined before and after 4 and 8 weeks of treatment. T exerted a potent inhibitory effect on ADP- and collagen-induced platelet aggregation. The effect of T was proportional to the pretreatment reactivity to ADP and collagen. The inhibitory effect of T on the epinephrine response was less pronounced. The plasma levels of beta-thromboglobulin, platelet factor 4 and fibrinogen were not influenced by T. The platelet inhibition of prostacyclin was potentiated by T, and it was demonstrated that T and prostacyclin had synergistic inhibitory effects on platelet aggregation.
The Effect of Pentosan Polysulphate (SP54) on the Fibrinolytic Enzyme System - A Human Volunteer and Experimental Animal Study
Authors: Marsh N A , Peyser P M , Creighton L J , Mahmoud M , Gaffney P J 
Published: July 2018

SummaryPentosan polysulphate causes an increase in plasminogen activator activity in plasma both after oral ingestion and after subcutaneous injection. The effect is greatest after 3 h and has disappeared by 6 h. Repeat doses by mouth over 5 days elicit a similar response. The recorded increase in activity is due largely to the release of tissue-type plasminogen activator (tPA) from the endothelium according to the antigen assay although there could be a small contribution from Factor XH-related “intrinsic” fibrinolysis induced in vitro. SP54 enhances activity ex vivo by a non-specific surface effect, and this phenomenon may contribute the increased levels of activity seen in vitro. Administration of SP54 to animals elicits a similar increase in activator activity, the intramuscular route being slightly more effective. Results with an inferior vena cava thrombosis model in the rat suggest that pentosan polysulphate may induce a thrombolytic effect.
Heparin Small Pool High Yield Purified Factor VIII: In Vivo Recovery and Half-Life of Routinely Produced Freeze-Dried Concentrate
Authors: Sibinga C T Smit , Daenen S M G J , Imhoff G W van , Maas A , Das P C 
Published: July 2018

SummaryNew approaches and techniques for improving source material collection and Factor VIII production at Blood Bank level have been reported recently.Heparin has been shown to be of importance in increasing yields and stability of FVIII in the purification and concentration process. Work has been done to develop on a routine scale the heparin double cold precipitation technique for the production of a freeze-dried high yield purified FVIII concentrate.The product has been tested clinically in 4 severe hemophilia A patients for recovery, half-life and acute side-effects, using two dosages over 8 infusions. There was no significant difference between the two dosages. Mean recovery 99.1% and mean halflife 8 hr, ranging from 6.5 to 10.3 hr.No side-effects were observed.These results justify further exploration of the potential of heparin for high yield purified FVIII production.