bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les métamorphoses du sujet à l’ère du virtuel : enjeux contemporains d’une clinique hypermoderne
Authors: Godart Elsa 
Published: October 2018

Notre monde semble soumis à nombre de métamorphoses qui viennent jusqu’à interroger les fondements même de l’humanité en l’homme. Ce monde c’est celui de l’hypermodernité et de la virtualité, produisant un nouvel éthos . Or, si le monde se métamorphose, et en se métamorphosant produit de nouveaux comportements, qu’en est-il des répercussions qu’il peut y avoir sur le sujet ? Qu’en est-il des métamorphoses du sujet à l’ère du virtuel ? Cette question nous conduit à analyser dans un premier temps l’essence même de ces probables métamorphoses ( nous présentons plusieurs changements de paradigmes fondamentaux : le rapport au temps et à l’espace et le passage d’une société dominée par la raison (logos) à une société régie par le règne d’images-éphémères (eidôlon) ; ainsi que l’importance de l’avénement d’une société de la jouissance au détriment d’une société du désir) ; puis dans un second temps, de réfléchir sur l’impact de ces métamorphoses sur la subjectivité. À la suite de cela, nous avons mis au jour l’importance de ce mouvement propre à la métamorphose dans lequel s’inscrit le sujet : subjectivation/désubjectivation/resubjectivation. Ce mouvement, ces métamorphoses, – qui donnent lieu à des symptômes hybrides, entre le normal et le pathologique, ce que l’auteur appelle des « malaises » – aboutissent à une subjectivité augmentée.
Le « Deep Curse » et l’égosystème. Matériaux pour une théorie de la cybermodernité
Authors: Cespedes Vincent 
Published: October 2018

Notre ère est « cybermoderne » : le virtuel et le réel s’intriquent à tel point qu’ils font notre monde, comme notre façon de l’appréhender, d’en profiter, de le changer. Société non plus « fluide » ou « liquide », mais translucide : faussement transparente – l’intime partagé n’en est pas vraiment un, mais du pseudo-intime composé en messages diffusables, du privé destiné à devenir public. « Translucide », aussi, au sens sorcier d’« extralucidité » : les traces virtuelles que nous laissons révèlent ce que nous sommes ; nos goûts et nos choix nous définissent et, massivement récoltées, définissent ce qu’est un groupe, un pays, l’humanité entière. L’auteur, philosophe, nous introduit au nouveau paradigme du siècle : la « transréalité ». À la fois un « Envoûtement profond » et une métamorphose riche en potentialités.
Le mal extrême, arcanum imperii, arcanum humani . Un regard intégré sur la notion d’emprise
Authors: De Rosa Barbara 
Published: October 2018

En partant d’une analyse sémantique et conceptuelle de la notion d’emprise, à travers un regard interdisciplinaire, je propose une réflexion sur l’exercice du pouvoir absolu sur le plan du collectif et de l’individuel à la fois ; mon argumentation supporte d’une part l’hypothèse d’un noyau de base commun à la naissance de l’individu et de la communauté, articulé autour des dynamiques de l’emprise, et de l’autre l’hypothèse d’une fonction défensive du phantasme de détresse que ces dynamiques expriment et dont les manifestations extrêmes se retrouvent dans la dérive totalitaire.
Droit privé, réglementation et justice
Authors: Hesselink Martijn 
Published: October 2018

Cet article porte un regard critique sur la thèse du Droit privé réglementaire européen (ERPL). La plus grande force de l’ERPL est qu’il offre une perspective entièrement nouvelle sur le droit privé européen. Toutefois, en tant que théorie exhaustive du droit privé européen, l’ERPL est trop unilatéral, d’un point de vue à la fois descriptif et normatif. Le fait qu’il se concentre fortement sur le droit privé enfermé dans des silos réglementaires pour des secteurs du marché spécifiques dissimule la réalité de l’acquis touchant au droit de la consommation et sa force transformative. Un tableau plus complet inclurait les contours d’un système plus ou moins cohérent de droit privé européen qui émerge à l’heure actuelle. Les principaux piliers de ce système pragmatique sont (pour l’instant) les droits de rétractation, le contrôle des clauses abusives et les remèdes en cas de non-conformité. De plus, la contribution du droit privé européen à la justice de l’accès ne peut pas être l’unique standard pour son évaluation et sa critique ; la justice interpersonnelle et la légitimité démocratique sont au moins aussi importantes.
Incidence of Retinal Disease Following Refractive Surgery in 9,239 Eyes
Authors: Ma Ruiz-Moreno José , Alió Jorge L 
Published: October 2018

ABSTRACT
PURPOSE: To analyze the appearance, incidence, and characteristics of retinal diseases in myopic patients after refractive surgery.
METHODS: We studied retinal disease observed in 9,239 consecutive eyes (5,099 patients) after refractive surgery. Photorefractive keratectomy (PRK) was used to correct myopia in 5,936 eyes (3,184 patients, mean age 30.5±8.9 years); mean spherical equivalent refraction was -4.71±2.80 D. Laser in situ keratomileusis (LASIK) was used to correct myopia in 3,009 eyes (1,734 patients, mean age 32.0±7.8 years); mean spherical equivalent refraction was -13.5i3.30 D. An anterior chamber phakic intraocular lens (PIOL) was implanted to correct myopia in 294 eyes (181 patients, mean age 32.6±7.3 yr) with a mean spherical equivalent refraction of -18.5*5.00 D.
RESULTS: Retinal detachment occurred at a mean 53.6*41.4 months after PRK in 9 eyes (0.15%), 24.6±20.4 months after LASIK in 11 eyes (0.36%), and 20.5±17.4 months after anterior chamber PIOL implantation in 12 eyes (4.08%). Choroidal neovascularization occurred a mean 26 months after PRK in 1 eye (0.01%), mean 30.2±19.3 months after LASIK in 10 eyes (0.33%), and mean 49.0±33.5 months after PACL implantation in 7 eyes (2.38%). One patient developed a macular hole 12 months after LASIK and another patient developed a macular hemorrhage immediately after LASIK. Epiretinal membrane appeared in one patient 19 months after anterior chamber PIOL implantation.
CONCLUSION: There was no relationship between PRK for myopia and retinal disease. LASIK for correction of myopia was followed by a low incidence of retinal disease; additional study is necessary to assess the true impact of the suction ring in the myopic eye. Implantation of an anterior chamber PIOL to correct high myopia was followed by a low incidence of choroidal neovascularization, a high incidence of retinal detachment, similar to other intraocular interventions in highly myopic patients. [J Refract Surg 2003;19:534-5471
Les « civic tech » à l’épreuve des partis politiques
Authors: Theviot Anaïs , Treille Éric 
Published: October 2018

En créant Les Créateurs du possible et La Coopol, l’UMP et le PS ont souhaité s’inspirer de l’émergence du mouvement des « civic tech » pour faire remonter les idées citoyennes et pour ouvrir les débats partisans aux non-adhérents. Toutefois, ces ambitions se sont vues fortement contrariées par le manque de participation en ligne et la volonté d’encadrer « par le haut » le fonctionnement de ces plateformes d’inclusion militante.
Phenotyping of Rh, Kell, Duffy and Kidd blood group antigens among non-tribal and tribal population of South Gujarat and its implication in preventing alloimmunisations in multitransfused patients.
Authors: Shah Avani , Ghosh Kanjaksha , Sharma Preeti , Mishra Kanchan 
Published: October 2018

Background:Sickle cell anaemia is common amongst Tribal population of south Gujrat. Alloimmunisation in multitransfused sickle cell anaemia patient is 10 times commoner in these patients than beta Thalassemia major patients from regular blood donor communities.
Study design & methodology: Red cell antigen typing of Rh (D,C,E,c,e ), Kell (K, k), Duffy (Fya, Fyb) and Kidd (Jka, Jkb) were carried out in 222 regular voluntary blood donors who belonged to non-tribal population and in 113 samples of tribal population using conventional antisera.
Results: Rh D antigen frequency was 96.6% in non-tribal and 96.5% in tribal population. 2.4% of K antigen was found in non-tribal population whereas the antigen was absent in tribal population .Amongst Rh antigens, e was the most common (100%) followed by D, C (91.0%, 85.8%), c (50.5%, 44.2%) and E (16.5%, 17.0%) with DCe/DCe (R1R1, 48.0%, 55.8%) being the most common phenotype in both the groups. In Kell antigens k antigen was 100% ,Kidd and Duffy antigens Jk (a+b-) (39.2%, 46.9%) and Fy (a+b-) (64.2%, 52.2%) were the most common phenotypes in non-tribal and tribal population respectively.
Conclusion: There is significant difference in Duffy , Kidd and Kell (k) antigen distribution between non tribal and tribal population . Total absence of Kell antigen in tribalsalong with. E antigen in a significant portion of blood donors and its absence in large number of tribals also increase the risk of alloimmunisation.
Infratentorial Epidural Abscess Secondary to Furunculosis: Case Report and a Review of the Literature
Authors: Menéndez Ricardo Horacio , Erice Santiago German , Vázquez Emmanuel Alejandro , Breitburd Karina 
Published: October 2018

ABSTRACTThe authors describe a case of infratentorial epidural abscess caused by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in a patient with a recent history of cutaneous furunculosis. This 29-year-old male presented with an occipital headache associated with fever, vomiting, and neck stiffness. Admission magnetic resonance imaging showed a retrocerebellar epidural abscess. Antimicrobial therapy was started, and the patient underwent craniectomy for evacuation of the abscess. Cultures of the surgical specimen were consistent with CA-MRSA. Postoperatively, the patient's condition improved with the resolution of symptoms, and he was discharged home with indication of 6 weeks of antibiotic therapy. Furunculosis is a very rare cause of intracranial epidural abscess but should be considered as a source of infection in an immunocompetent patient.
Burr-Hole Evacuation of Chronic Subdural Hematoma: Biophysically and Evidence-Based Technique Improvement
Authors: Májovský Martin , Netuka David , Beneš Vladimír , Kučera Pavel 
Published: October 2018

ABSTRACTChronic subdural hematoma (CSDH) is one of the most common neurosurgical conditions. Despite ongoing efforts, recurrence and reoperation rates after surgical treatment remain high. We synthesize scientific evidence on the treatment of CSDH with biophysical principles and then propose a simple and effective surgical technique aiming to reduce the recurrence rate. Under local anesthesia, one burr hole is placed in the area above the maximum hematoma thickness. One drain is inserted into the dorsal direction to the deepest point of the hematoma cavity, and a second drain is inserted frontally into the highest point. Next, saline is gently instilled to the dorsal drain to eliminate air from the hematoma cavity through the frontal drain. Once saline has filled the frontal drain, the frontal drain is removed. The dorsal drain is left in situ for 48 h, and the pressure within the cavity may be adapted hydrostatically. We implemented evidence-based conclusions of previous studies and modified the classical burr-hole technique to reduce the recurrence rate. As a result, we developed a straightforward surgical procedure that is possible to perform under local anesthesia, suitable for everyday practice in rural and remote areas while working with limited resources. The novelty of this technique is in the purposeful reduction of postoperative pneumocephalus, a known independent factor of recurrence. Subdural air is eliminated during surgery using a two-drain system. Safety and efficacy of the technique need to be evaluated in future clinical trials.
Body weight prediction using body size measurements in Fleckvieh, Holstein, and Brown Swiss dairy cows in lactation and dry periods
Authors: Gruber Leonhard , Ledinek Maria , Steininger Franz , Fuerst-Waltl Birgit , Zottl Karl , Royer Martin , Krimberger Kurt , Mayerhofer Martin , Egger-Danner Christa 
Published: October 2018

Abstract. The objective of this study was to predict cows' body weight from body size measurements and other animal data in the lactation and dry periods. During the whole year 2014, 6306 cows (on 167 commercial Austrian dairy farms) were weighed at each routine performance recording and body size measurements like heart girth (HG), belly girth (BG), and body condition score (BCS) were recorded. Data on linear traits like hip width (HW), stature, and body depth were collected three times a year. Cows belonged to the genotypes Fleckvieh (and Red Holstein crosses), Holstein, and Brown Swiss. Body measurements were tested as single predictors and in multiple regressions according to their prediction accuracy and their correlations with body weight. For validation, data sets were split randomly into independent subsets for estimation and validation. Within the prediction models with a single body measurement, heart girth influenced relationship with body weight most, with a lowest root mean square error (RMSE) of 39.0 kg, followed by belly girth (39.3 kg) and hip width (49.9 kg). All other body measurements and BCS resulted in a RMSE of higher than 50.0 kg. The model with heart and belly girth (ModelHG BG) reduced RMSE to 32.5 kg, and adding HW reduced it further to 30.4 kg (ModelHG BG HW). As RMSE and the coefficient of determination improved, genotype-specific regression coefficients for body measurements were introduced in addition to the pooled ones. The most accurate equations, ModelHG BG and ModelHG BG HW, were validated separately for the lactation and dry periods. Root mean square prediction error (RMSPE) ranged between 36.5 and 37.0 kg (ModelHG BG HW, ModelHG BG, lactation) and 39.9 and 41.3 kg (ModelHG BG HW, ModelHG BG, dry period). Accuracy of the predictions was evaluated by decomposing the mean square prediction error (MSPE) into error due to central tendency, error due to regression, and error due to disturbance. On average, 99.6 % of the variance between estimated and observed values was caused by disturbance, meaning that predictions were valid and without systematic estimation error. On the one hand, this indicates that the chosen traits sufficiently depicted factors influencing body weight. On the other hand, the data set was very heterogeneous and large. To ensure high prediction accuracy, it was necessary to include body girth traits for body weight estimation.
As vias de negação da vontade em Schopenhauer
Authors: Ribeiro Lívia 
Published: October 2018

Neste artigo analiso como se da a transição da afirmação para a negaça o da vontade em suas duas vias, a do conhecimento e apropriaça o do sofrimento alheio e a do sofrimento radicalmente sentido. Para isso, exponho os atos compassivos como meios de fomentar a negaça o e questiono se há um tipo de caráter que favoreça o surgimento da negação pela primeira via, enquanto a segunda via torna possível a negação da vontade independente do caráter que o indivíduo expressava antes dessa experiência.
Adipose tissues of MPC1± mice display altered lipid metabolism-related enzyme expression levels
Authors: Zou Shiying , Zhu Liye , Huang Kunlun , Luo Haoshu , Xu Wentao , He Xiaoyun 
Published: October 2018

Mitochondrial pyruvate carrier 1 (MPC1) is a component of the MPC1/MPC2 heterodimer that facilitates the transport of pyruvate into mitochondria. Pyruvate plays a central role in carbohydrate, fatty, and amino acid catabolism. The present study examined epididymal white adipose tissue (eWAT) and intrascapular brown adipose tissue (iBAT) from MPC1± mice following 24 weeks of feeding, which indicated low energy accumulation as evidenced by low body and eWAT weight and adipocyte volume. To characterize molecular changes in energy metabolism, we analyzed the transcriptomes of the adipose tissues using RNA-Sequencing (RNA-Seq). The results showed that the fatty acid oxidation pathway was activated and several genes involved in this pathway were upregulated. Furthermore, qPCR and western blotting indicated that numerous genes and proteins that participate in lipolysis were also upregulated. Based on these findings, we propose that the energy deficiency caused by reduced MPC1 activity can be alleviated by activating the lipolytic pathway.
Uncovering full-length transcript isoforms of sugarcane cultivar Khon Kaen 3 using single-molecule long-read sequencing
Authors: Piriyapongsa Jittima , Kaewprommal Pavita , Vaiwsri Sirintra , Anuntakarun Songtham , Wirojsirasak Warodom , Punpee Prapat , Klomsa-ard Peeraya , Shaw Philip J. , Pootakham Wirulda , Yoocha Thippawan , Sangsrakru Duangjai , Tangphatsornruang Sithichoke , Tongsima Sissades , Tragoonrung Somvong 
Published: October 2018

Background
Sugarcane is an important global food crop and energy resource. To facilitate the sugarcane improvement program, genome and gene information are important for studying traits at the molecular level. Most currently available transcriptome data for sugarcane were generated using second-generation sequencing platforms, which provide short reads. The de novo assembled transcripts from these data are limited in length, and hence may be incomplete and inaccurate, especially for long RNAs.

Methods
We generated a transcriptome dataset of leaf tissue from a commercial Thai sugarcane cultivar Khon Kaen 3 (KK3) using PacBio RS II single-molecule long-read sequencing by the Iso-Seq method. Short-read RNA-Seq data were generated from the same RNA sample using the Ion Proton platform for reducing base calling errors.

Results
A total of 119,339 error-corrected transcripts were generated with the N50 length of 3,611 bp, which is on average longer than any previously reported sugarcane transcriptome dataset. 110,253 sequences (92.4%) contain an open reading frame (ORF) of at least 300 bp long with ORF N50 of 1,416 bp. The mean lengths of 5′ and 3′ untranslated regions in 73,795 sequences with complete ORFs are 1,249 and 1,187 bp, respectively. 4,774 transcripts are putatively novel full-length transcripts which do not match with a previous Iso-Seq study of sugarcane. We annotated the functions of 68,962 putative full-length transcripts with at least 90% coverage when compared with homologous protein coding sequences in other plants.

Discussion
The new catalog of transcripts will be useful for genome annotation, identification of splicing variants, SNP identification, and other research pertaining to the sugarcane improvement program. The putatively novel transcripts suggest unique features of KK3, although more data from different tissues and stages of development are needed to establish a reference transcriptome of this cultivar.
Comparative functional analysis of proteins containing low-complexity predicted amyloid regions
Authors: Kumari Bandana , Kumar Ravindra , Chauhan Vipin , Kumar Manish 
Published: October 2018

Background
In both prokaryotic and eukaryotic proteins, repeated occurrence of a single or a group of few amino acids are found. These regions are termed as low complexity regions (LCRs). It has been observed that amino acid bias in LCR is directly linked to their uncontrolled expansion and amyloid formation. But a comparative analysis of the behavior of LCR based on their constituent amino acids and their association with amyloidogenic propensity is not available.

Methods
Firstly we grouped all LCRs on the basis of their composition: homo-polymers, positively charged amino acids, negatively charged amino acids, polar amino acids and hydrophobic amino acids. We analyzed the compositional pattern of LCRs in each group and their propensity to form amyloids. The functional characteristics of proteins containing different groups of LCRs were explored using DAVID. In addition, we also analyzed the classes, pathways and functions of human proteins that form amyloids in LCRs.

Results
Among homopolymeric LCRs, the most common was Gln repeats. LCRs composed of repeats of Met and aromatic amino acids were amongst the least occurring. The results revealed that LCRs composed of negatively charged and polar amino acids were more common in comparison to LCRs formed by positively charged and hydrophobic amino acids. We also noted that generally proteins with LCRs were involved in transcription but those with Gly repeats were associated to translational activities. Our analysis suggests that proteins in which LCR is composed of hydrophobic residues are more prone toward amyloid formation. We also found that the human proteins with amyloid forming LCRs were generally involved in binding and catalytic activity.

Discussion
The presented analysis summarizes the most common and least occurring LCRs in proteins. Our results show that though repeats of Gln are the most abundant but Asn repeats make longest stretch of low complexity. The results showed that potential of LCRs to form amyloids varies with their amino acid composition.
MONTAGEM E ESTUDO DE UM QUIMIOSSENSOR CROMOGÊNICO PARA A DETECÇÃO DE CIANETO E DE ÁLCOOIS UTILIZANDO UM ÁCIDO BORÔNICO COMO RECEPTOR E UM CORANTE SOLVATOCRÔMICO COMO UNIDADE SINALIZADORA
Authors: Machado Vanderlei Gageiro , Testoni Fabíola Maria , Schuhmacher Samya Maren , Zimmermann-Dimer Lizandra Maria , Nicolini Jaqueline 
Published: October 2018

Estudos foram realizados para analisar o comportamento do ácido fenil borônico (AB) em acetonitrila na presença da merocianina de Brooker (MB) e do corante de Reichardt. Verificou-se, por exemplo, que a adição de AB a uma solução de MB fez desaparecer a banda solvatocrômica do corante em 571,0 nm simultaneamente ao aparecimento de outra banda em 385,9 nm. Sugeriu-se que em excesso de AB, o complexo predominante apresenta uma estequiometria AB-MB 1:1, mas que se a concentração de AB for diminuída, uma mistura de três complexos, AB-MB, AB-(MB)2 e AB-(MB)3, é obtida. Foi verificado que o sistema AB-MB pode ser usado eficientemente como um quimiossensor para o fluoreto e para o cianeto, pois somente os dois ânions, dentre os vários estudados, tornaram violeta a solução incolor de AB-MB. Isto se deve ao fato de que estes ânions são ótimos nucleófilos e podem interagir eficazmente com o centro de boro, deslocando nucleofilicamente a MB, que pode assim colorir a solução. Ensaios também foram realizados para a montagem de um quimiossensor cromogênico para detecção de álcoois, usando-se AB e a MB. Foi observado que o complexo AB-MB atua eficientemente como quimiossensor cromogênico, permitindo a discriminação entre álcoois primários, secundários e terciários. Esta discriminação visual pode ser explicada pelo fato de que, com o aumento do impedimento estéreo no álcool, a interação com o centro de boro fica dificultada, tornando a reação mais lenta. Palavras-chave: quimiossensor cromogênico, detecção visual, merocianina de Brooker, álcoois, cianeto.