bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved APEX Model Simulation of Buffer Water Quality Benefits at Field Scale
Authors: Senaviratne G. M. M. M. Anomaa , Baffaut Claire , Lory John A. , Udawatta Ranjith P. , Nelson Nathan O. , Williams Jimmy R. , Anderson Stephen H. 
Published: April 2018

Abstract. Watershed models offer cost-effective means to quantify the environmental benefits of conservation practices. This study evaluated the ability of the Agricultural Policy/Environmental eXtender (APEX) model to simulate the effectiveness of upland buffers for reducing event runoff, sediment, and total phosphorus (TP) loadings. The study used 16 years of monitoring data (1993-2008) from three field-scale row crop watersheds. Two watersheds had buffers installed in the fall of 1997, one with upland agroforestry buffers (grass plus trees) and the second with upland grass buffers; the third watershed was maintained as a control. Objectives were to (1) determine the effect of upland buffers on APEX parameters, (2) evaluate the ability of APEX to estimate upland buffer effectiveness, and (3) evaluate the impact of alternative buffer placement options on water quality outcomes. After modification of the APEX code to improve simulation of infiltration in the buffers, we successfully calibrated APEX for no-buffer and upland buffer conditions for event runoff and TP. However, calibrated parameters from the no-buffer model simulated buffer conditions poorly and resulted in an overestimation of buffer effectiveness. Buffer effectiveness estimated with upland buffer parameters was similar to that obtained from measured data. Scenario analysis indicated that a combination of backslope and footslope agroforestry buffers was more effective than contour placement for reducing average annual edge-of-field runoff and total P losses. These results highlight the complexity of using APEX to assess upland buffers as well as potential problems when using APEX to quantify the benefits of conservation practices not included in the calibration dataset. Keywords: Agroforestry buffers, Buffer placement, Modeling, Phosphorus, Practice effectiveness, Watershed discretization.
Babel: The abject cosmopolitan and the border
Authors: Urtiaga Rosa 
Published: April 2018

Abstract
In Alejandro González Iñárritu’s Babel, a Mexican nanny represents those undocumented domestic workers that constantly move north and south the US–Mexico border as part of global circuits. I build on the concept of the ‘abject cosmopolitan’, coined by Peter Nyers, and on classical theories of abjection. I also draw from theories about the global feminization of work, gender and migration, and transnational domestic service. From a cosmopolitan perspective that is sensitive to gender, race and class, this article explores the ways in which Babel counters long-held stereotypes and enables audiences to erode borders between strangers.
Red Betel Leaves Methanolic Extract (Piper crocatum Ruiz & Pav.) Increases Cytotoxic Effect of Doxorubicin on WiDr Colon Cancer Cells through Apoptosis Induction
Authors: Wulandari Nindi , Meiftasari Argandita , Fadliyah Hilyatul , Jenie Riris Istighfari 
Published: April 2018

Doxorubicin is a chemotherapeutic agent that causes a lot of side effects in high doses. Thus, combination with a co-chemotherapeutic agent which can increase its toxicity on cancer cells, is needed to reduce its therapeutic dose. Red betel leaves (Piper crocatum Ruiz & Pav.) have been known to contain flavonoids and alkaloids that have anticancer activity. This study was conducted to determine the cytotoxic effect and apoptosis induction of red betel leaves methanolic extract (RBM), doxorubicin (dox) and the combination of them on WiDr cells as model of colon cancer. RBM was extracted by soxhlet method using methanol. Cytotoxicity assay was performed using MTT assay for both single and combination treatments for 24 hours to determine IC50 and CI as their parameters. Apoptosis induction was analyzed by double staining method using ethidium bromide-acridine orange staining. Treatment of RBM and dox on WiDr cells for 24 hours showed cytotoxic activity with IC50 100 μg/mL and 1.6 μM respectively. Combination of RBM and dox performed synergism effect with CI<0.9 (p<0.05). Combination of RBM (12.5 μg/mL) and dox (0.4 μM) increased the number of apoptosis cells compared to each single treatment. Based on this study, it can be concluded that red betel leaves methanolic extract is potential to be developed as a co-chemotherapeutic agent of doxorubicin on colon cancer but still need further study to disclose the underlying molecular mechanisms.Keywords : Red betel leaves (Piper crocatum Ruiz & Pav.), doxorubicin, WiDr cells, co- chemotherapeutic agent
Multiarm spirals on the periphery of disc galaxies
Authors: Lubov Spiegel , Evgeny Polyachenko 
Published: April 2018

Abstract
Spiral patterns in some disc galaxies have two arms in the centre, and three or more arms on the periphery. The same result is also obtained in numerical simulations of stellar and gaseous discs.We argue that such patterns may occur due to fast cooling of the gas, resulting in formation of giant molecular clouds. The timescale of this process is 50 Myr, the factor of 10 shorter than of ordinary secular instability. The giant molecular clouds give rise to multiarm spirals through the mechanism of swing amplification.
Relationship between body composition and selected motor components in 17-year-old adolescents residing in the city of Poznań in Poland
Authors: Glapa Agata , Grzesiak Joanna , Monyeki Makama Andries 
Published: April 2018

Summary
Study aim: The objective of this study was to determine differences in body composition status and levels of selected motor components and assess the relationship between selected motor components and body composition in adolescent girls and boys.
Material and methods: The study participants were 42 girls and 49 boys from a secondary school in the city of Poznan in Po­land who were participating in the “Active not only online” project. The percentage of body components was evaluated using a bio-impedance method. The modified Eurofit battery of tests was used to assess selected motor components.
Results: The prevalence of overweight was higher (12.3%) in boys than girls (2.4%), and girls were more frequently under­weight (16.7%) than boys (6.1%). The results of the study show higher selected motor component levels in girls than in boys when compared to standardized population norms. BMI correlated positively with 20-m shuttle run (r = 0.45, p < 0.05) in girls and with sit and reach (r = 0.30, p < 0.05) in boys, with ‘hand grip’ strength both in girls (r = 0.35, p < 0.05) and boys (r = 0.29, p < 0.05), and was related to percentage of body fat in girls (r = 0.33, p < 0.05) and boys (r = 0.42, p > 0.05).
Conclusions: The findings showed that sex and body composition are important factors influencing physical fitness in adoles­cents. We suggest that these factors be considered when designing physical activity interventions.
High microRNA-28-5p expression in colorectal adenocarcinoma predicts short-term relapse of node-negative patients and poor overall survival of patients with non-metastatic disease
Authors: Tsiakanikas Panagiotis , Kontos Christos K. , Kerimis Dimitrios , Papadopoulos Iordanis N. , Scorilas Andreas 
Published: April 2018

Abstract

Background:
MicroRNAs (miRNAs) may function either as oncogenes or tumor suppressors and are heavily involved in the initiation and progression of cancer, and in metastasis of tumor cells. MicroRNA-28-5p (miR-28-5p) targets several cancer-related genes and is hence involved in cell proliferation, migration, invasion and epithelial-mesenchymal transition. In this study, we investigated the potential diagnostic and prognostic significance of miR-28-5p expression in colorectal adenocarcinoma, the most frequent type of colorectal cancer (CRC).

Methods:
Therefore, we isolated total RNA from 182 colorectal adenocarcinoma specimens and 86 paired non-cancerous colorectal mucosae. After polyadenylation of 2 μg total RNA and its reverse transcription using an oligo-dT-adapter primer, we quantified miR-28-5p levels using an in-house-developed reverse-transcription real-time quantitative polymerase chain reaction (RT-qPCR) method, based on the SYBR Green chemistry.

Results:
Comparison of miR-28-5p levels among 86 pairs of colorectal tumors and their adjacent non-cancerous mucosae uncovered the downregulation of miR-28-5p expression in the majority of malignant colorectal tumors. More importantly, high miR-28-5p expression predicts poor disease-free survival (DFS) and overall survival (OS) of colorectal adenocarcinoma patients. Multivariate Cox regression analysis revealed that miR-28-5p overexpression is a significant predictor of poor prognosis in colorectal adenocarcinoma, independent of tumor size, histological grade, TNM staging, radiotherapy and chemotherapy. Interestingly, strong miR-28-5p expression retains its predictive potential regarding relapse among patients with negative regional lymph nodes, and predicts poor OS in patients diagnosed with non-metastatic colorectal adenocarcinoma.

Conclusions:
High miR-28-5p expression predicts poor DFS and OS of colorectal adenocarcinoma patients, independently of clinicopathological prognosticators and standard patient treatment, including radiotherapy and chemotherapy.
On the freeness of hypersurface arrangements consisting of hyperplanes and spheres
Authors: Gao Ruimei , Dai Qun , Li Zhe 
Published: April 2018

Abstract
Let V be a smooth variety. A hypersurface arrangement 𝓜 in V is a union of smooth hypersurfaces, which locally looks like a union of hyperplanes. We say 𝓜 is free if all these local models can be chosen to be free hyperplane arrangements. In this paper, we use Saito’s criterion to study the freeness of hypersurface arrangements consisting of hyperplanes and spheres, and construct the bases for the derivation modules explicitly.
Trichuris trichiurain the mummified remains of southern Siberian nomads
Authors: Slavinsky Vyacheslav Sergeyevich , Chugunov Konstantin Vladimirovich , Tsybankov Alexander Alekseevich , Ivanov Sergey Nikolaevich , Zubova Alisa Vladimirovna , Slepchenko Sergey Mikhailovich 
Published: April 2018

Abstract
Echo and heart failure: when do people need an echo, and when do they need natriuretic peptides?
Authors: Modin Daniel , Andersen Ditte Madsen , Biering-Sørensen Tor 
Published: April 2018

Abstract
Heart failure (HF) is a threat to public health. Heterogeneities in aetiology and phenotype complicate the diagnosis and management of HF. This is especially true when considering HF with preserved ejection fraction (HFpEF), which makes up 50% of HF cases. Natriuretic peptides may aid in establishing a working diagnosis in patients suspected of HF, but echocardiography remains the optimal choice for diagnosing HF. Echocardiography provides important prognostic information in both HF with reduced ejection fraction (HFrEF) and HFpEF. Traditionally, emphasis has been put on the left ventricular ejection fraction (LVEF). LVEF is useful for both diagnosis and prognosis in HFrEF. However, echocardiography offers more than this single parameter of systolic function, and for optimal risk assessment in HFrEF, an echocardiogram evaluating systolic, diastolic, left atrial and right ventricular function is beneficial. In this assessment echocardiographic modalities such as global longitudinal strain (GLS) by 2D speckle-tracking may be useful. LVEF offers little value in HFpEF and is neither helpful for diagnosis nor prognosis. Diastolic function quantified by E/e′ and systolic function determined by GLS offer prognostic insight in HFpEF. In HFpEF, other parameters of cardiac performance such as left atrial and right ventricular function evaluated by echocardiography also contribute with prognostic information. Hence, it is important to consider the entire echocardiogram and not focus solely on systolic function. Future research should focus on combining echocardiographic parameters into risk prediction models to adopt a more personalized approach to prognosis instead of identifying yet another echocardiographic biomarker.
Rapid Integration of Multi-copy Transgenes Using Optogenetic Mutagenesis inCaenorhabditis elegans
Authors: Noma Kentaro , Jin Yishi 
Published: April 2018

AbstractStably transmitted transgenes are indispensable for labeling cellular components and manipulating cellular functions. In Caenorhabditis elegans, transgenes are generally generated as inheritable multi-copy extrachromosomal arrays, which can be stabilized in the genome through a mutagenesis-mediated integration process. Standard methods to integrate extrachromosomal arrays primarily use protocols involving ultraviolet light plus trimethylpsoralen or gamma- or X-ray irradiation, which are laborious and time-consuming. Here, we describe a one-step integration method, following germline-mutagenesis induced by mini Singlet Oxygen Generator (miniSOG). Upon blue light treatment, miniSOG tagged to histone (Histone-miniSOG) generates reactive oxygen species (ROS) and induces heritable mutations, including DNA double-stranded breaks. We demonstrate that we can bypass the need to first establish extrachromosomal transgenic lines by coupling microinjection of desired plasmids with blue light illumination on Histone-miniSOG worms to obtain integrants in the F3 progeny. We consistently obtained more than one integrant from 12 injected animals in two weeks. This optogenetic approach significantly reduces the amount of time and labor for transgene integration. Moreover, it enables to generate stably expressed transgenes that cause toxicity in animal growth.
Propiedades psicométricas del cuestionario de salud sf-36 en estudiantes universitarios de San Ramón, Alajuela - Sede Occidente, Universidad de Costa Rica
Authors: Araya Marín Noemy , Barrantes Valverde Karla , Fernández Castro Mariam , Rodríguez Rodríguez Marselly , García Castro Juan Diego 
Published: April 2018

Este estudio busca conocer las propiedades psicométricas del Cuestionario SF-36 sobre el Estado de Salud en estudiantes universitarios de San Ramón, Costa Rica. La muestra consistió en 200 estudiantes, mujeres y hombres. Se realizaron entrevistas cognitivas y se consultó una experta, posteriormente se analizó su confiabilidad y validez. Dentro de los resultados destaca el índice Alfa de Cronbach global de =.80 y los coeficientes por dimensión con valores desde α=.72 (Salud General) hasta α=.88 (Salud Mental). El coeficiente Spearman-Brown contó con un resultado promedio de =.75 y todas las dimensiones presentaron niveles por encima de .72, excepto la dimensión Salud General .60. El análisis de componentes principales respalda la presencia de dos dimensiones, explicando un 37,59% de la varianza.
Gestor Integral del Recurso Hídrico, un experto necesario ante la vulnerabilidad socio-natural
Authors: Bolaños Alfaro John Diego 
Published: April 2018

El presente artículo denota el trabajo de la Comisión elaboradora de la propuesta curricular y todo el trabajo realizado para establecer los principios fundamentales reales y naturales provenientes de las ciencias naturales y sociales tendientes a la resolución de problemas y actividades propias del agua, rompiendo con los paradigmas de gestión actuales. Se presenta el profesional como un recurso humano indispensable para el mercado nacional con la capacidad de realizar nuevas prácticas de gestión, educación ambiental, participación comunitaria y el saneamiento del agua. Ante una crisis de gobernabilidad del recurso hídrico clara y evidente, con la vulnerabilidad y escasez agua visible en varias comunidades del país, se espera que el profesional, mejore la tutela, el aprovechamiento, la protección y el uso sostenible del recurso hídrico, utilizando la perspectiva de manejo de cuenca hidrológica, como unidad básica de planificación y gestión del recurso hídrico. Finalmente, se denota el proceso constructivo de la nueva carrera y su atinencia a nivel país, teniendo como principal empleador a los entes encargados de la administración del agua a nivel público o privado.
OBRAS PÚBLICAS REQUERIDAS VS. OBRAS PÚBLICAS EJECUTADAS: CASUÍSTICA DE LA REGIÓN CARIBE COLOMBIANA
Authors: Ayala Borrero María Camila , Díaz Córdoba Yuliana , Pérez Ruíz Diego Darío , Serrano Guzmán María Fernanda 
Published: April 2018

Las regiones naturales de Colombia son divisiones territoriales que se establecen en función de atributosgeográficos como relieve, clima, vegetación, cultura, hidrografía, entre otros aspectos. En esteartículo se presenta el resultado de la investigación adelantada acerca de la relación existente entre lasnecesidades detectadas en los planes de ordenamiento territorial (POT) y las obras de infraestructuraejecutadas en la región Caribe. Para ello, se revisaron los POTs de las ciudades capitales Riohacha,Cartagena, Barranquilla, Montería, Sincelejo, Santa Marta, Valledupar, Montería, y se compararonlos proyectos formulados y ejecutados para dar respuesta a las problemáticas identificadas por lascomunidades, información que debería estar disponible en la plataforma del Servicio Electrónico deContratación (SECOP). Finalmente, el estudio reveló que las comunidades presentan necesidades insatisfechas en los sectores vial y de saneamiento básico y aun así los proyectos reportados y ejecutadoscorresponden a otros objetos, lo cual puede explicar la diferencia en el desarrollo de la región. Resultacuestionable que, aunque las necesidades sean unas, los proyectos ejecutados sean otros, situación querepercute en el indicador de desempeño fiscal y de desarrollo municipal obtenido en estas comunidades.
Salvadora Persica (Misvak) Bitkisinden Elde Edilen Uçucu Yağın Antioksidan ve Antimikrobiyal Aktivitelerinin Araştırılması
Authors: APAYDIN Elif 
Published: April 2018

Bu çalışmanın
amacı; Salvadora persica (misvak)
bitkisinden elde edilen uçucu yağın
antioksidan ve antimikrobiyal etkilerini araştırmaktır. Bu bitkinin
çalışılma sebebi; misvağın uzun zamandır tüm dünyada diş sağlığı ve temizliği
alanında kullanılmasıdır. Bu çalışma farklı spektroskobik yöntemler ve GC-MS
ile açıklamaya çalışıldı.

Bu amaçla 250 gram misvak tozu,
hidrodistilasyon yöntemi ile clevenger aparatında yağ ekstraksiyonu yapıldı,
susuz Na2SO4
ile su uzaklaştırıldı ve 4 ͦ C buzdolabında yağlar saklandı. Uçucu yağ
bileşenleri GC-MS ile tanımlandı. Uçucu yağların antimikrobiyal özellikleri
disk difüzyon yöntemi ile Parvathy ve
arkadaşları metoduna göre yapıldı. DPPH radikal süpürme ve Hidrojen peroksit
süpürme kapasitesi spetkrofotometrik yöntem ile yapıldı. Farklı mineraller ve
ağır metalleri ICP-MS ile analiz edildi.
Türkiye’deki bazı Oleaceae türlerinde perforasyonlu özışını hücreleri
Authors: Erşen Bak Funda , Merev Nesime 
Published: April 2018

Türkiye’de Oleaceae
familyası Fraxinus L., Fontanesia
Labill, Phillyrea L., Olea L., Osmanthus Lour., Ligustrum L., Jasminum L. olmak üzere 7 cins’e ait 14 doğal takson
ile temsil edilmektedir. Familyanın Fraxinus dışındaki diğer cinsleri yalnızca bir
takson ile yayılış göstermektedir. Oleaceae’nin bazı cins ve türlerinde
perforasyonlu özışını hücreleri daha önce rapor edilmiş olsa da, Phillyrea
latifolia L., Ligustrum
vulgare L. ve Olea europaea L. türlerinde perforasyonlu özışını
hücrelerinin varlığı ilk kez bu çalışma ile ortaya konulmuştur. İncelenen
örneklerde, radyal çeperlerinde trahe hücrelerindeki gibi basit
perforasyon tablası bulunduran, etrafındaki özışını hücrelerinden daha geniş
olan perforasyonlu özışını hücreleri
oldukça yoğundur.
Entre o Regional e o Universal: (Outros) Tecidos da Literatura Gaúcha
Authors: Silveira Ederson Luís , Dering Renato De Oliveira 
Published: April 2018

O regionalismo gaúcho esteve historicamente permeado de singularidades, tendo a construção do tipo característico “centauro dos pampas” predominante em muitos escritos do gênero. Mesmo que a literatura gaúcha goze de multiplicidade de textos, que retomem características específicas dos lugares em que foram construídas, há textos que rumam para a universalidade com poucas referências ao regional. A presente pesquisa bibliográfica de cunho qualitativo visa empreender reflexões acerca da literatura gaúcha, que se desprende do regionalismo característico para aventurar-se pelos terrenos da universalidade. Se para Ítalo Calvino, o clássico é aquele que não terminou de dizer o que tinha para dizer, Anne-Marie Thiesse intitulou o “check-list identitário” uma série de especificidades capazes de garantir a singularidade de determinado grupo social. Neste contexto, ter-se-á a análise da obra Pequenas epifanias, de Caio Fernando Abreu. Os resultados apontam que obras como esta se constituem a exceção à regra sem perder reconhecimento, com seu lugar entre os pares da literatura regional, mesmo que fuja da “pureza inicial” caracterizadora da literatura gaúcha. Palavras-chave: Literatura Regional. Crônica. Crítica Literária. Universal. AbstractThe Rio Grande do Sul regionalism was historically permeated by singularities, with the construction of the characteristic type “centaur of Pampas” prevalent in a lot of writings. Even though the Rio Grande do Sul literature enjoys a multitude of texts that comprise specific features aboutthe places wherethey were built, there are texts that head for the universality with few references to the regional. This bibliographical research of qualitative nature aims at undertaking reflections about the Gaucho literature which breaks loose from characteristic regionalism to venture out towards the universality land. To Italo Calvino, the classic is the one that has not finished saying what he or she had to say, AnneMarie Thiesse entitled the “check-list identity” a series of special features capable of ensuring the uniqueness of a particular social group. In this context, there is the analysis of the book Pequenas epifanias, by Caio Fernando Abreu. The results show that books like this are an exception to the rule without losing recognition, with its place among the pairs of regional literature, even though it deviates from the “original purity” characterizing the Gaúcha literature. Keywords: Regional Literature. Chronic. Literary Criticism.Universal.