bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macht zu viel kaufen krank?
Authors: de Zwaan M. , Mueller A. 
Published: September 2018

ZusammenfassungPathologisches Kaufen ist ein kulturspezifischer Verhaltensexzess, bei dem ohne vernünftige Motivation unnütze Dinge oder Dinge in unnützen Stückzahlen erworben werden, die anschließend kaum oder gar nicht benutzt werden. Das unkontrollierte Kaufverhalten führt zu psychischen, sozialen, beruflichen, finanziellen und mitunter strafrechtlichen Problemen. In klinischen Stichproben wurde eine sehr hohe Komorbidität mit anderen psychiatrischen Erkrankungen beobachtet, v.a. mit Depressionen, Angststörungen, Zwangsstörungen, Substanzabhängigkeit, Binge Eating Störung, zwanghaftem Horten, Persönlichkeitsstörungen und intermittierender explosiver Störung. Aktuell wird die Verhaltenspathologie als n.n.b. Impulskontrollstörung klassifiziert (ICD-10 F63.9). Für störungsspezifische kognitive Verhaltenstherapie liegen erste Wirksamkeitsnachweise vor. Es besteht weiterer Forschungsbedarf hinsichtlich eines störungsspezifischen Ätiologiemodells, der Klassifikation und bezogen auf Behandlungskonzepte. Da neben psychologischen Faktoren auch eine hohe Konsumorientierung und dysfunktionale Einstellungen zum Geld eine Rolle spielen, sollte das Phänomen in interdisziplinären Forschergruppen untersucht werden.
Sport als Therapieoption bei Schizophrenie
Authors: Wobrock T. , Falkai P. , Malchow B. 
Published: September 2018

ZusammenfassungHintergrund: Obwohl Sport bei psychischen Störungen empfohlen wird, fehlen insbesondere bei der Therapie der Schizophrenie wissenschaftliche Untersuchungen bezüglich der spezifischen Effekte von körperlichem Training. Methodik: In einer ersten randomisierten und kontrollierten Studie unterzogen sich chronisch schizophrene Patienten und gematchte gesunde Kontrollpersonen einem aeroben Ausdauertraining über einen Zeitraum von drei Monaten. Als Kontrollbedingung spielten acht schizophrene Patienten über denselben Zeitraum Tischfußball. Vor und nach der Intervention wurde das Hippokampusvolumen mittels struktureller Magnetresonanztomographie (sMRT) und die neuronale Integrität mittels Protonen-Magnetresonanzspektroskopie (1H-MRS) gemessen. Neuropsychologische und klinische Variablen wurden ebenfalls erhoben. Ergebnisse: Nach dem aeroben Ausdauertraining nahm das relative Hippokampusvolumen bei den schizophrenen Patienten (+12%) wie auch den gesunden Kontrollprobanden (+16%) signifikant zu, in der Tischfußballgruppe hingegen nicht (–1%). Die Volumenzunahme in der Sportgruppe korrelierte mit der Zunahme der körperlichen Fitness, eine Verbesserung des verbalen Kurzzeitgedächtnisses in der kombinierten Gruppe aus schizophrenen Sportlern und Tischfußballspielern mit der Änderung des Hippokampusvolumens. Schlussfolgerung: Die Resultate der beschriebenen Studie zeigen, dass sich sowohl bei gesunden Probanden als auch bei schizophrenen Patienten neuroplastische Effekte im Hippokampus durch Ausdauersport induzieren lassen. Damit scheint individuell austarierter Ausdauersport eine sinnvolle Ergänzung im Therapiekonzept von Schizophrenien darzustellen.
Long-Term Results of Compressive Brace Therapy for Pectus Carinatum
Authors: Moon Duk , Kang Min , Lee Hye , Lee Sungsoo 
Published: September 2018

Background Pectus carinatum (PC) is one of the most common types of congenital chest wall deformity. Recently, noninvasive compressive brace therapy has been more frequently used than invasive surgical correction to treat PC. Hence, the purpose of this study was to determine the long-term outcome of compressive brace therapy.
Methods We retrospectively reviewed patients with PC who underwent compressive brace therapy between January 2014 and December 2016. All patients underwent a 2-week compression period, in which braces were worn for 20 hours per day, followed by a 6-month maintenance period, in which braces were worn for 12 hours per day. Patient satisfaction was investigated via telephone survey.
Results A total of 320 patients were included in this study. The average age was 13 years, and 280 were males (87.5%). The median follow-up period was 42 months (13–68). Good compliance was observed in 286 patients (89.4%; compliance group). In this group, the initial Haller index significantly increased from 2.20 ± 0.31 to 2.59 ± 0.38 after the 6-month therapy period (p = 0.001). After the 6-month period, 255 patients (89.1%) and 31 patients (12.1%) in the compliance group were very satisfied and satisfied, respectively. Satisfaction at the last follow-up via telephone survey was very satisfied in 250 patients (87.4%) and satisfied in 36 (12.6%). In the compliance group, no patient needed compressive braces again after the therapy period.
Conclusion Given the findings presented in this study, compressive brace therapy appears to be a relatively simple and safe method with good long-term outcome in treating patients with PC.
Tongue-in-Groove Technique for Rhinoplasty: Technical Refinements and Considerations
Authors: Spataro Emily , Most Sam 
Published: September 2018

AbstractA key concept in successful rhinoplasty surgery is maintaining or increasing tip support, and addressing tip projection and rotation. The tongue-in-groove (TIG) technique is a method to achieve this goal using sutures to create a strong connection between the septum and medial crura to change tip rotation and projection. Criticisms of this method include that it may cause stiffness of the nasal tip and columellar retraction. TIG is routinely used by the authors during anterior septal reconstructions (a modified extracorporeal septoplasty technique), as well as in primary and revision aesthetic and functional rhinoplasties. Through this review, technical aspects of the TIG technique are discussed, as well as how pitfalls of the technique can be avoided, as illustrated by several rhinoplasty patient examples.
Changes in the remuneration system for psychiatric care in Japan
Authors: Ito H. 
Published: September 2018

SummaryJapan’s psychiatric care is reimbursed according to official prices called “national fee schedule,” which is revised once every 2 years. Fee schedule revisions have had a major influence on medical service providers in Japan, where the rate of private health care institutions is high. The increase of acute beds in inpatient care and the fee schedule for outpatient care have been promoted since the 1990’s. As a result, inpatient care has diverged into acute care units and geriatric units focused primarily on long-term care. In addition, outpatient care services have increased dramatically. Under these circumstances, some key challenges faced by Japan’s psychiatric care include poorly defined catchments areas and how to improve the evaluation of health care quality. Furthermore, the degree to which psychiatric care should assume the responsibility of geriatric care in Japan’s super-aging society remains a topic of debate.
Rationale Therapie von Aggressivität und psychomotorischen Erregungszuständen mit Zuclopenthixol
Authors: Messer T. , Glaser T. , Häßler F. 
Published: September 2018

ZusammenfassungZuclopenthixol ist ein mittelpotentes Antipsychotikum aus der Reihe der Thioxanthene. Es ist in Deutschland zugelassen für die Behandlung von akuter und chronischer Schizophrenie, Manie, psychomotorischen Erregungszuständen und aggressiven Verhaltensweisen bei Demenz sowie psychomotorischer Erregung bei geistiger Behinderung. In der vorliegenden Übersichtsarbeit wird die Evidenzlage zum Einsatz dieser Substanz bei psychomotorischen Erregungszuständen und Aggressivität dargestellt. Besondere Berücksichtigung finden neuere Daten zur Wirksamkeit von Zuclopenthixol bei der Behandlung auto- und fremdaggressiven Verhaltens von Menschen mit Intelligenzminderung.
Forensische Psychiatrie
Authors: Müller J. L. , Stolpmann G. 
Published: September 2018

ZusammenfassungDie Forensische Psychiatrie ist ein Spezialgebiet der Psychiatrie, das durch vielfältige Bezüge zu anderen wissenschaftlichen Fachbereichen eine fächerübergreifende Disziplin ist und traditionell im Fokus öffentlicher Aufmerksamkeit steht. Dies gilt in besonderem Maße für die Schuldfähigkeits- und Prognosebegutachtung, die hier in den Grundzügen dargestellt werden. Exemplarisch für den klinischen Aspekt der Forensischen Psychiatrie wird der Maßregelvollzug skizziert und im Zusammenhang mit der Sicherungsverwahrung soll das besondere Spannungsverhältnis dargestellt werden, in dem sich die Forensische Psychiatrie durch die von verschiedenen Seiten an sie herangetragenen Erwartungen und Forderungen immer wieder befindet.
Schwerpunkte in der Psychiatrie
Authors: Gutzmann H. , Haupt M. 
Published: September 2018

ZusammenfassungIm Fachgebiet der Psychiatrie hat die Gerontopsychiatrie die medizinische Versorgung der psychisch kranken älteren Menschen zum Gegenstand. Das Krankheitsspektrum ist breit; mit Abstand sind Demenzen und Depressionen am häufigsten; relevante weitere Krankheitsbilder umfassen delirante Zustände, Angststörungen, schizophrene Störungen, Suchterkrankungen und Schlafstörungen. Der Beitrag hebt für ausgewählte Krankheitsbilder die notwendige spezifische gerontopsychiatrische Kompetenz in Diagnostik, Therapie und Versorgungsmanagement hervor. Zudem werden die besonderen gerontopsychiatrischen Versorgungsstrukturen und die aktuelle Versorgungswirklichkeit dargestellt. Den Abschluss bildet eine kurze Erläuterung der Kernstandpunkte der Deutschen Gesellschaft für Gerontopsychiatrie und –psychotherapie (DGGPP).
Neuropsychiatrie als Spezialisierung
Authors: Gelderblom H. , Heinz A. , Priller J. 
Published: September 2018

ZusammenfassungDas Gehirn ist nicht teilbar. Es ist das morphologische Substrat neurologischer und psychiatrischer Erkrankungen. Neuere Entwicklungen der Neurowissenschaften erlauben zunehmend, psychische Störungen einem strukturellen oder funktionellen Korrelat im Gehirn zuzuweisen. Die psychiatrischen Manifestationen neurologischer Erkrankungen wie z.B. der Basalganglienerkrankungen oder der Multiplen Sklerose werden zunehmend in ihrer Komplexität erkannt und stellen nicht selten eine therapeutische Herausforderung dar. Auch die Wechselwirkungen zwischen psychischen Störungen und neurologischer Komorbidität bedürfen innovativer Therapieansätze. Im Bereich der Demenzen besteht ein hoher medizinischer Bedarf an Strategien für die Behandlung von Verhaltensstörungen (BPSD). Die Neuropsychiatrie kann in diesen Bereichen einen wichtigen Beitrag zur Forschung und Versorgung leisten. Die Autoren sehen die Aufgabe der Neuropsychiatrie darin, die Trennung der Mutterdisziplinen Psychiatrie und Neurologie zu überbrücken. Anlässlich der DGPPN 2011 möchten wir eine Diskussionsgrundlage für die Etablierung der Neuropsychiatrie als eigenständige medizinische Disziplin liefern und zugleich Vorschläge für Ergänzungen der Ausbildungs- und Weiterbildungskataloge des Faches Psychiatrie und Psychotherapie machen.
Kann Neuropsychologie helfen, Störungen im psychotischen Kontinuum zu differenzieren?
Authors: Watzke S. 
Published: September 2018

ZusammenfassungAuf einem Kontinuum von Schizophrenie zu affektiven Störungen können schizoaffektive Störungen, akute vorübergehende psychotische Störungen und anhaltende wahnhafte Störungen verortet werden. Diese Theorie eines psychotischen Kontinuums wird durch Befunde über genetische, biologische, klinisch-phänomenologische, verlaufsdynamische und prognostische Aspekte insbesondere zu schizoaffektiven Störungen gestützt. Über kognitive Beeinträchtigungen im psychotischen Kontinuum liegt hingegen eine eingeschränkte Studienlage vor. Diese schmale Datenbasis wird präsentiert, zwei eigene Studien zu kognitiven Leistungsmerkmalen bei bipolar schizoaffektiven Störungen und anhaltenden wahnhaften Störungen werden vorgestellt. Neuropsychologische Studien können dazu beitragen, die Annahmen des psychotischen Kontinuums über eine graduelle Zunahme kognitiver Beeinträchtigungen zwischen den Erkrankungsgruppen zu erweitern. Implikationen für die psychiatrische Diagnostik werden diskutiert.
The Encyclopedia of Proteome Dynamics: the KinoViewer
Authors: Brenes Alejandro , Lamond Angus I 
Published: September 2018

Abstract

Summary
The Encyclopedia of Proteome Dynamics (EPD) ‘KinoViewer’ is an interactive data visualization tool designed for analysis and exploration of both protein and transcript data, showing expression of kinase genes in either human or mouse cells and tissues. The KinoViewer provides a comprehensive, updated graphical display of all human/mouse kinases and an open access analysis tool for the community with a user-friendly graphical interface.

Availability and implementation
The KinoViewer is based on a manually drawn SVG, which is utilized with D3.js to create a dynamic visualization. It can be accessed at: https://peptracker.com/epd/analytics/. The KinoViewer is currently only accessible through the EPD, it is open access and can be used either to view internal datasets, or used to upload and visualize external user datasets.

Supplementary information
Supplementary data are available at Bioinformatics online.
FA03.03: RISK FACTORS FOR MALLORY-WEISS TEAR DURING ENDOSCOPIC SUBMUCOSAL DISSECTION OF SUPERFICIAL ESOPHAGEAL NEOPLASMS
Authors: Chen Wei , Wu Junchao , Gan Tao , Yang Jinlin 
Published: September 2018

Abstract

Background
Adverse events such as perforation and bleeding during endoscopic submucosal dissection (ESD) of superficial esophageal neoplasms have been well acquainted. However, Mallory Weiss Tear (MWT) during esophageal ESD is still under obscurity. Therefore, this study was carried out to elucidate the incidence and risk factors for MWT during esophageal ESD.

Methods
Patients received ESD for superficial esophageal neoplasms from June, 2014 to July 2017 in our institution were retrospectively analyzed. Clinicopathological characteristics of the patients were collected. Patients were allocated into MWT group or non-MWT group based on the presence of MWT occurred during ESD. The incidence of MWT was determined and the risk factors for MWT were identified.

Results
A total of 337 patients with 373 lesions treated by ESD were analyzed. 20 patients developed MWT during ESD (5.4%). Multivariate analysis identified female gender (OR = 5.36, 95%CI: 1.47–19.50, P = 0.011) and procedure time (OR = 1.01, 95%CI: 1.00–1.02, P = 0.048) were independent risk factors for MWT during ESD. The characteristics of the esophageal lesions had no influence on the development of MWT. The vast majority of patients with MWT did not receive endoscopic treatment for the laceration and seven of the MWT patients received endoscopic hemostasis using APC, hemoclips, or hemoclips combined with endoloop. All the patients recovered satisfactorily without surgery for the laceration. We believe the placement of gastrointestinal decompression tube and the use of PPI and hemostatic drugs after ESD contributed to the hemostasis and mucosal healing.

Conclusion
The incidence of MWT during esophageal ESD was much higher than expected. Although most cases had a benign course, fetal conditions such as massive hemorrhage may also occur. We recommend an inspection of the stomach after ESD procedure in order to take timely management in case of bleeding MWT or even perforation outside the procedure region.

Disclosure
All authors have declared no conflicts of interest.
FA03.05: NEOADJUVANT CHEMOTHERAPY OR CHEMORADIOTHERAPY FOR ADENOCARCINOMA OF THE ESOPHAGUS
Authors: Visser Els , Edholm David , Smithers Mark , Thomson Iain , Burmeister Bryan , Walpole Euan , Gotley David , Joubert Warren , Atkinson Victoria , Mai Tao , Thomas Janine , Barbour Andrew 
Published: September 2018

Abstract

Background
Multimodality treatment of patients with esophageal adenocarcinoma (EAC) improve survival, but the optimal treatment strategy remains undetermined. The aim of this study was to compare outcomes in patients undergoing neoadjuvant chemotherapy (nCT) and neoadjuvant chemoradiotherapy (nCRT) for EAC.

Methods
Patients who underwent nCT or nCRT followed by surgery for EAC were identified from a prospective database (2000–2017) and included in this study. After propensity score matching, we compared the impact of the treatments on postoperative complications, in-hospital mortality, pathological outcomes and survival rates.

Results
Of the 396 eligible patients, 262 patients were analysed following propensity score matching. This resulted in 131 patients in the nCT group versus 131 patients in the nCRT group. There were no significant differences between the nCT and nCRT groups for overall complications (59% vs 57%, P = 0.802) or in-hospital mortality (2% vs 0%, P = 0.156). Patients who had nCRT had more R0 resections (93% vs. 83%, P = 0.013), and a higher pathological complete response rate (15% vs. 5%, P < 0.001). The pattern of recurrence was similar (P = 0.753) and there were no differences in 5-year disease-free survival rates (nCT vs nCRT; 39% vs 39%, P = 0.879) or 5-year overall survival rates (nCT vs nCRT; 44% vs 33%, P = 0.645).

Conclusion
In this study no differences between nCT and nCRT were seen in postoperative complications and in-hospital mortality in patients treated for EAC. Inspite of improved complete resection and pathological response there was no difference in the overall survival between the treatment modalities.

Disclosure
All authors have declared no conflicts of interest.
FA04.03: MIE VERSUS RAMIE: PROMISING RESULTS OF A SINGLE-CENTER AND SINGLE-SURGEON ANALYSIS
Authors: Grimminger Peter , Tagkalos Evangelos , Hadzijusufovic Edin , Babic Benjamin , Lang Hauke 
Published: September 2018

Abstract

Background
Robot assisted surgery for esophageal cancer is rapidly increasing, especially high-volume centers with access to a robot. The fully robotic minimally invasive esophagectomy using 4 robotic arms in the abdomen and thorax (RAMIE4) is performed as standard procedure in our department. In this analysis we compare the results of our first 50 RAMIE4 procedures with our last 50 fully minimally-invasive esophagectomies (MIE), which was our standard prior the robotic era.

Methods
Between April 2016 and March 2018, the data from 100 consecutive patients with esophageal carcinoma undergoing modified Ivor-Lewis esophagectomy, performed by the same surgeon using the identical intrathoracic anastomotic reconstruction technique (circular stapler). 50 patients were treated with MIE and the other 50 with RAMIE4. Demographic data, extracted lymph nodes and R-status were compared. Complications occurred were compered according to the Dindo-Clavien classification.

Results
Demographic data did not show significant differences between the groups. The overall 30- and 90- mortality rates were 1% (1/100) and 3% (3/100) respectively (P = 0.305 and P = 0.499 respectively). In the RAMIE group the median lymph node harvest was significantly higher (27 vs. 23; P = 0.045), the median hospital stay was less in the RAMIE group, however not significantly (11.5d vs 13d; P = 0.112), the median ICU stay was significantly lower in the RAMIE group compared to MIE (1d vs 2.5d; P = 0.002). The complications according to the Dindo-Calvien classification were not significantly different between the two groups (P = 0.091).

Conclusion
In this study we were able to demonstrate the superiority of robotic assisted lymph node dissection for esophageal cancer surgery in a highly comparable setting. In addition the perioperative parameters, especially ICU stay seem to be in favor of RAMIE. The future potential of standardized RAMIE and RAMIE4 seems to be high.

Disclosure
All authors have declared no conflicts of interest.
FA04.06: RESECTION OF HEPATIC AND PULMONARY METASTASIS FROM ESOPHAGEAL AND GASTRIC CANCER: A NATIONWIDE STUDY
Authors: Van Der Veen A , Seesing Mfj , Brenkman Hjf , Stockmann Hba , Nieuwenhuijzen Gap , Rosman Camiel , Van Den Wildenberg Frits , Van Berge Henegouwen Mark I , Van Duijvendijk P , Wijnhoven Bpl , Stoot Jh , Lacle M , Ruurda Jelle , Hillegersberg Richard 
Published: September 2018

Abstract

Background
Best supportive care or palliative chemotherapy is the standard of care for gastroesophageal cancer patients with hepatic or pulmonary metastases, leading to a median survival of 4–11 months. Occasionally, patients with oligometastatic disease may be eligible for curative treatment. The aim of the current study was to evaluate the outcomes of all patients in the Netherlands who underwent a resection of hepatic or pulmonary metastases with curative intent for metastatic gastroesophageal cancer.

Methods
The Dutch National Registry for Histo- and Cytopathology was used to identify all patients who underwent a resection of hepatic or pulmonary metastasis from gastroesophageal cancer. Patients who were treated with curative intent and had available patient records were included. Data on treatment and outcomes were retrieved from the patient's record. Kaplan-Meier survival analysis was performed.

Results
The primary tumor of 34 patients with gastroesophageal cancer was resected in 21 different hospitals between 1991–2016. Additionally, resection of hepatic metastasis was performed in 19 patients and of pulmonary metastasis in 15 patients. Only 4 patients received neoadjuvant therapy before metastasectomy. The majority of patients had solitary, metachronous metastases. After metastasectomy, grade 3 (Clavien-Dindo) complications occurred in 7 patients and mortality in 1 patient. After resection of hepatic metastases, the median overall survival (OS) was 28 months and the 1-, 3- and 5- year OS were 84%, 41% and 31% respectively. After pulmonary metastases resection, the median OS was not reached and the 1-, 3- and 5- year OS were 67%, 53% and 53% respectively.

Conclusion
In selected patients with gastroesophageal cancer with hepatic or pulmonary metastases, metastasectomy was performed with limited morbidity and mortality and offered a 5-year OS of 31–53%. Further prospective studies are required.

Disclosure
All authors have declared no conflicts of interest.