bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gearing Toward CCUS for CO2 Reduction in Malaysia
Authors: Hassan Hatarmizi , Omar Nik Fauziah Nik , Jalil Abdullah Al-Mubarak Md , Salihuddin Radin Suhaib , Shah Sahriza Salwani Md 
Published: March 2018

Abstract
PETRONAS has embarked on Research & Development (R&D) of Carbon Capture, Utilization and Storage (CCUS) related technologies since 2011. The main purpose in pursuing R&D in this area is to monetize high CO2 gas fields through technology development. At initial stage, area that has been focusing were on capture, transportation and storage only. Later, utilization became an area of focus since there is a need to convert CO2 to valuable product in order to make high CO2 gas fields development more viable. R&D in the area of CO2 capture namely advanced membrane separation, advanced cryogenic distillation as well as supersonic technologies were conducted. For ultra high CO2 gas field (&gt; 50 mol% CO2), a hybridization of separation technology are key to ensure economic viability of the fields development. In term of CO2 storage, several critical areas has been studied especially wells drilling technology, CO2 injectivity, storage technology involving geomechanic & geochemistry fields model and measurement as well as monitoring and verification technologies for the stored CO2. CO2 mineralisation technology is also explored to convert CO2 into valuable product. Furthermore, K5 Strategic Technology Project is undertaken in order to showcase and prove all the newly develop technologies.
Well Integrity Risk Assessment - Software Model for the Future
Authors: Brechan Bjorn , Dale Stein Inge , Sangesland Sigbjorn 
Published: March 2018

AbstractRisk is a topic reaching over many layers in an organization and its structure. From operator and asset level to individual wells and operations. The oil and gas industry's joint consensus of primary focus is safe and effective production. This is reflected in the growing efforts in the area of Well Integrity. The essence of Well Integrity is "containment" and the essence of a Well Integrity Risk Assessment (WIRA) is to demonstrate containment capacity in a scenario where barrier elements fail to meet industry standards and requirements. Risk assessments often adhere to guidelines in ISO 16530 part 1 "Life cycle governance" and part 2 "Well integrity for the operational phase". Following the practice outlined in these standards, understanding the risk starts with a procedure for identifying the risk level of the individual wells and then goes on to evaluate the impact to – and the total asset risk level.When a parameter indicates a weakness in a barrier, the general procedure is to investigate until the source is identified and the associated risk is understood. In many cases, the error indicator, trouble shooting procedure, and final risk assessment is triggered by a failure known and familiar to the many experienced Well Integrity organizations operating wells. These organizations are processing vast amounts of data to understand the Well Integrity, the risk at single well level and asset level associated by producing one or more wells with deviating behavior. Software exists to support the daily efforts in Well Integrity, but a digitalization process can make a step change. The basis of a new Life Cycle Well Integrity Model (LCWIM) has been developed. Risk assessment support as function of the integrity indicators is one of the features planned for the LCWIM. The scope of this paper is to outline how risk assessment processes often are performed in Well Integrity, and establish the key components in a plan for an autonomous process, where the LCWIM generates the risk assessment based on the signals transmitted from the well.
Successful Implementation of Narrow Margin Drilling Procedures to Optimise a Deepwater Well
Authors: Yusof M Syahmi M , Khazali-Rosli Khairul Amir , Ezzatty Nurul Nadia , Prasertamporn Praisont , Arathoon Mark , Sockalingam Shatiskumar , Hwa Chong Chew , Muhamad Ezzatul Akmal 
Published: March 2018

Abstract
Narrow margin procedures incorporating MPD techniques were developed to tackle the challenges of drilling a deepwater well DW-X, offshore Malaysia. The subsurface prognosis had a ‘most likely’ case with a narrow pore pressure – fracture gradient (PPFG) window of between 0.5ppg and 1.0 ppg, all the way from seabed to well total depth (TD). The prognosed high case did not even permit the well to be drilled to TD. The narrow margin approach was used in both pre-drill and drilling phases. The pre-drill phase included the overall well design, section TD decision trees, communication protocol, mud rollover plans, MPD plans and hydraulic and kick tolerance simulation. The drilling phase involved real-time updates to the data, with ongoing simulation updates, MPD utilisation decision trees, and specific operational procedures, such as finger printing, MPD static flowchecks and MPD leak off tests. Since this was an exploration well with limited offset data, there was high PPFG uncertainty in every hole section. Therefore, narrow margin procedures and processes were implemented in each hole section after the BOP had been landed, until well TD had been reached.
The pre-drill plan focused on minimising ECD, through optimal casing design, BHA design and mud and cement design. Hydraulic simulations were run with mud hydrostatically at balance with the pore pressure, using applied surface back pressure from MPD to keep bottom hole pressure constant and equalt to the ECD pressure, at all times. Kick tolerance was simulated with a multiphase gas model to be as realistic as possible, and also to be not overly conservative as would be the case for a standard single bubble model. During drilling, the simulations were updated real-time with the actual data from the well, to optimisation casing shoe placement for each section. This led to elimination of the 11-3/4" and 7" liners, providing significant cost and time savings to the well.
By optimising the operational procedures and reviewing the MPD utilisation for each section, the well was safely drilled to TD, only using MPD in those sections that required it, even though MPD had originally been planned for all sections. The combination of finding slightly wider PPFG windows than predicted, and finding MPD surface-line back pressures slightly higher than modelled, meant that MPD was not beneficial in all hole sections. The well was successfully drilled to TD, below cost and time compared to the original AFE, in spite of extending TD by more than 150m to cope with deeper formation tops than prognosis. Thus all of the drilling objectives were successfully delivered in the well. The approach described in this paper can be applied to future narrow margin deepwater wells, with valuable lessons learned on MPD setup and utilisation for each hole section.
Innovative Robot Development for Maintenance and Inspection
Authors: Kulwatthanasal Ronnapoom 
Published: March 2018

Abstract
A heat exchanger is a critical component in oil and gas process. The proper performance of shell and tube heat exchangers within a process can affect the cost of the final product, or even the production rate. Unfortunately, heat exchangers are prone to fouling caused by fluids flowing within and over the tubes, and the reduction in heat transfer that results, almost invariably has an impact on production cost. To reduce this impact, heat exchanger performance should be intelligently monitored and the tube cleaning is required to remove fouling and increase the heat exchanger performance. The existing tube cleaning method is Manual Water Jet Cleaning. Generally the Manual Water Jet Cleaning requires an operator to manually feed the nozzle. Holding on to a hose while high pressure water rushes through it can lead to operator fatigue over time and there is a risk to operator controlling the high pressure water jet near the water blasting and it can be time-consuming because there is only one nozzle to clean one tube at a time.
Robots have served in various industries for many years, but now the science of robot is developing at such a rapid pace that robots have become far more diverse, infinitely smarter and are being used in ways that we would not have dreamt possible as few years ago, especially in the offshore oil and gas industries. In keeping with modern trends, the team has developed the heat exchanger cleaning method through the application of the Robot system. The system can clean 3 tubes simultaneously, providing the highest level of productivity. Robot also provides the most protection and comfort to the operator because the lateral movements of the flexible hoses and the vertical movements of Robot can be controlled remotely. The original design of the Robot structure cannot be installed at the offshore location because of the limited area. Therefore the team has had an innovative idea to redesign the Robot structure in order to extend the cleaning space by mounting it on the scaffolding. This is a new structural design for oil and gas offshore operation.
Success Story of Integrated Reservoir Characterization and Reservoir Management Approach to Deliver Infill Wells in the MTJDA Area, North Malay Basin
Authors: Setiawan A. S. , Simatupang M. H. , Rachmadi A. , Ratanavanich S. , Pushiri M. F. Mohd 
Published: March 2018

Abstract
In the event of high gas demand, infill well drilling is one of the best option to increase gas deliverability. Finding infill well opportunity in a brown field is a challenging task. Reservoir continuity, heterogeneity of the rock properties, pressure depletion and identifying undrained area are the major concern for infill wells candidate selection. A robust reservoir characterization and dynamic information are essential to provide some key understanding about the field.
The area of interest, Muda field, is located in the Block B-17 of Malaysia-Thailand Joint Development Area (MTJDA) which has been producing for more than 5 years. Integration of multidisciplinary data is very important to identify the potential hydrocarbon bypassed area. To start with, the geological model was built and constrained with seismic attributes after calibration to the well data. The high uncertainty of reservoir presence in the model was assessed by combining the sand distribution and porosity variation. Subsequently, history matching was performed to calibrate the model with actual production flow rates and reservoir pressure. A reasonably good history match was achieved and provides a certain degree of confidence in production forecast. As a result, it shows some potential undrained areas to be selected as the area of infill well candidate. The infill wells were drilled within 1 to 2 years later and the well results has demonstrated a successful delivery of infill well as expected both in encountered netpay and production.
This paper discusses a successful collaboration between multidisciplinary team members in the subsurface division to deliver infill well candidate by building a comprehensive reservoir model which integrate of all hard data from geological concept, seismic attribute, well and production. Five successful infill wells were drilled in accordance to this campaign, expected potential and volume are generally as expected with some surprises in some interval. The gas potential comes from these infills are very important to fulfil gas deliverability. It is foreseen that additional infill wells are expected and evaluated using the 3D reservoir model.
Experience in Process Safety IPF Study & Verification
Authors: Jelani Ir. Nur Alina 
Published: March 2018

Abstract
In the Oil & Gas business it is important to ensure the design of high risk process adequate with sufficient safety barrier. One of the most challenging application of Process Safety IPF Study and Verification is to balance between safeguard adequacies versus cost optimization.
PETRONAS has taken a stand that SAFETY is our upmost priority and with that process safety design has been our main priority. PETRONAS have many operating plant units in Malaysia as well as in other countries. Measures are taken in ensuring proper Functional Safety Risk Analysis are being carried out during project development stage and during plant operational phase.
This paper intends to highlight PETRONAS best practice in Process Safety SIL Study and Verification. It also discussed measures taken to resolve issues faced by O&M in ensuring SIL requirement is being met. In addition, initiatives within PETRONAS in incorporating IEC 61508 & IEC 61511 revision changes.
A Novel Dual-Packer Combination Solution for Achieving Isolation of Mild Sour Gas Lift from a Non-Nace Rated Top Tension Riser and Achieving Pre-Tensioning of a Dual Tubing String for Fatigue Avoidance
Authors: Saad Norzehan , Mun Wong Kim , Wong Jon , Hosatte Pierre 
Published: March 2018

Abstract
Novel well completion technique is used to ensure dual tubing performed under fatigue condition in Field B TLP. Based on initial tubing stress analyses, the dual strings are under compression during production. Also due to the Single Combo Top Tension Riser (SCTTR) design, first in the industry, the riser must be isolated from hydrocarbon flow. All 10 producers completed to date were tensioned successfully using this technique. This paper discusses various methods of string tensioning and executing the completion.
Robust Tracking Control for Underactuated Autonomous Underwater Vehicle in Horizontal Plane
Authors: Song Y. S. , Ali A. F. , Arshad M. R. 
Published: March 2018

Abstract
This paper presents a robust control for an underactuated Autonomous Underwater Vehicle (AUV) to track a predefined trajectory in horizontal plane. The AUV is uncontrollable in sway direction. First, the tracking error expressed in the earth-fixed frame is transformed into an introduced tracking error, so that the tracking error can be converged by using only force in surge direction and moment in yaw direction. Then, a unity gain, low pass filter is used to converge the introduced tracing error to zero and compensate the effect of added mass and hydrodynamic damping force acting on the AUV system. Tracking performance of the proposed controller is demonstrated via simulations for straight-line trajectory, circular trajectory, and sinusoidal trajectory.
Bach2 Promotes B Cell Receptor–Induced Proliferation of B Lymphocytes and Represses Cyclin-Dependent Kinase Inhibitors
Authors: Miura Yuichi , Morooka Mizuho , Sax Nicolas , Roychoudhuri Rahul , Itoh-Nakadai Ari , Brydun Andrey , Funayama Ryo , Nakayama Keiko , Satomi Susumu , Matsumoto Mitsuyo , Igarashi Kazuhiko , Muto Akihiko 
Published: March 2018

AbstractBTB and CNC homology 2 (Bach2) is a transcriptional repressor that is required for the formation of the germinal center (GC) and reactions, including class switch recombination and somatic hypermutation of Ig genes in B cells, within the GC. Although BCR-induced proliferation is essential for GC reactions, the function of Bach2 in regulating B cell proliferation has not been elucidated. In this study, we demonstrate that Bach2 is required to sustain high levels of B cell proliferation in response to BCR signaling. Following BCR engagement in vitro, B cells from Bach2-deficient (Bach2−/−) mice showed lower incorporation of BrdU and reduced cell cycle progression compared with wild-type cells. Bach2−/− B cells also underwent increased apoptosis, as evidenced by an elevated frequency of sub-G1 cells and early apoptotic cells. Transcriptome analysis of BCR-engaged B cells from Bach2−/− mice revealed reduced expression of the antiapoptotic gene Bcl2l1 encoding Bcl-xL and elevated expression of cyclin-dependent kinase inhibitor (CKI) family genes, including Cdkn1a, Cdkn2a, and Cdkn2b. Reconstitution of Bcl-xL expression partially rescued the proliferation defect of Bach2−/− B cells. Chromatin immunoprecipitation experiments showed that Bach2 bound to the CKI family genes, indicating that these genes are direct repression targets of Bach2. These findings identify Bach2 as a requisite factor for sustaining high levels of BCR-induced proliferation, survival, and cell cycle progression, and it promotes expression of Bcl-xL and repression of CKI genes. BCR-induced proliferation defects may contribute to the impaired GC formation observed in Bach2−/− mice.
Decay of the Stress-Induced Ligand MICA Is Controlled by the Expression of an Alternative 3′ Untranslated Region
Authors: Toledano Tirtsah , Vitenshtein Alon , Stern-Ginossar Noam , Seidel Einat , Mandelboim Ofer 
Published: March 2018

Abstract
Recognition of the human stress-induced ligand MHC class I polypeptide-related sequence A (MICA) by the receptor NKG2D expressed on NK cells leads to NK cell–mediated killing of the target cells. Hence, the expression of MICA must be tightly regulated, and its cell surface expression needs to be quickly downregulated to avoid inappropriate activation of immune cells. In this article, we describe a transcript variant of human MICA that has not yet been studied, which contains a 3′ untranslated region of 119 nt instead of 174. We identify its polyadenylation signal and demonstrate that, upon stresses, such as heat shock, butyrate treatment, and some oxidative and DNA-damaging treatments, the balance between the two MICA variants changes in favor of the less stable, longer variant. Mechanistically, we showed that this change is linked to microRNA activity and that poly-ADP ribose polymerase 1 is involved in the induction of the longer variant following stress. Thus, to our knowledge, we identify the first regulatory mechanism of a stress ligand’s decay and also provide one of the first physiological examples for the biological function of a longer 3′ untranslated region of a particular gene.
Intravesicular Acidification Regulates Lipopolysaccharide Inflammation and Tolerance through TLR4 Trafficking
Authors: Murase Motoya , Kawasaki Takumi , Hakozaki Rika , Sueyoshi Takuya , Putri Dyaningtyas Dewi Pamungkas , Kitai Yuichi , Sato Shintaro , Ikawa Masahito , Kawai Taro 
Published: March 2018

Abstract
TLRs recognize pathogen components and drive innate immune responses. They localize at either the plasma membrane or intracellular vesicles such as endosomes and lysosomes, and proper cellular localization is important for their ligand recognition and initiation of signaling. In this study, we disrupted ATP6V0D2, a component of vacuolar-type H+ adenosine triphosphatase (V-ATPase) that plays a central role in acidification of intracellular vesicles, in a macrophage cell line. ATP6V0D2-deficient cells exhibited reduced cytokine production in response to endosome-localized, nucleic acid-sensing TLR3, TLR7, and TLR9, but enhanced inflammatory cytokine production and NF-κB activation following stimulation with LPS, a TLR4 agonist. Moreover, they had defects in internalization of cell surface TLR4 and exhibited enhanced inflammatory cytokine production after repeated LPS stimulation, thereby failing to induce LPS tolerance. A component of the V-ATPase complex interacted with ARF6, the small GTPase known to regulate TLR4 internalization, and ARF6 deficiency resulted in prolonged TLR4 expression on the cell surface. Taken together, these findings suggest that ATP6V0D2-dependent intravesicular acidification is required for TLR4 internalization, which is associated with prevention from excessive LPS-triggered inflammation and induction of tolerance.
Intracellular Nucleic Acid Sensing Triggers Necroptosis through Synergistic Type I IFN and TNF Signaling
Authors: Brault Michelle , Olsen Tayla M. , Martinez Jennifer , Stetson Daniel B. , Oberst Andrew 
Published: March 2018

Abstract
The sensing of viral nucleic acids within the cytosol is essential for the induction of innate immune responses following infection. However, this sensing occurs within cells that have already been infected. The death of infected cells can be beneficial to the host by eliminating the virus’s replicative niche and facilitating the release of inflammatory mediators. In this study, we show that sensing of intracellular DNA or RNA by cGAS-STING or RIG-I-MAVS, respectively, leads to activation of RIPK3 and necroptosis in bone marrow–derived macrophages. Notably, this requires signaling through both type I IFN and TNF receptors, revealing synergy between these pathways to induce cell death. Furthermore, we show that hyperactivation of STING in mice leads to a shock-like phenotype, the mortality of which requires activation of the necroptotic pathway and IFN and TNF cosignaling, demonstrating that necroptosis is one outcome of STING signaling in vivo.
A High Throughput Whole Blood Assay for Analysis of Multiple Antigen-Specific T Cell Responses in Human Mycobacterium tuberculosis Infection
Authors: Whatney Wendy E. , Gandhi Neel R. , Lindestam Arlehamn Cecilia S. , Nizam Azhar , Wu Hao , Quezada Melanie J. , Campbell Angela , Allana Salim , Kabongo Mbuyi Madeleine , Khayumbi Jeremiah , Muchiri Benson , Ongalo Joshua , Tonui Joan , Sasser Loren E. , Fergus Tawania J. , Ouma Gregory Sadat , Ouma Samuel Gurrion , Beck Allison A. , Mulligan Mark J. , Oladele Alawode , Kaushal Deepak , Cain Kevin P. , Waller Lance , Blumberg Henry M. , Altman John D. , Ernst Joel D. , Rengarajan Jyothi , Day Cheryl L. ,   for the TBRU-ASTRa Study Group
Published: March 2018

Abstract
Antigen-specific CD4 and CD8 T cells are important components of the immune response to Mycobacterium tuberculosis, yet little information is currently known regarding how the breadth, specificity, phenotype, and function of M. tuberculosis–specific T cells correlate with M. tuberculosis infection outcome in humans. To facilitate evaluation of human M. tuberculosis–specific T cell responses targeting multiple different Ags, we sought to develop a high throughput and reproducible T cell response spectrum assay requiring low blood sample volumes. We describe here the optimization and standardization of a microtiter plate-based, diluted whole blood stimulation assay utilizing overlapping peptide pools corresponding to a functionally diverse panel of 60 M. tuberculosis Ags. Using IFN-γ production as a readout of Ag specificity, the assay can be conducted using 50 μl of blood per test condition and can be expanded to accommodate additional Ags. We evaluated the intra- and interassay variability, and implemented testing of the assay in diverse cohorts of M. tuberculosis–unexposed healthy adults, foreign-born adults with latent M. tuberculosis infection residing in the United States, and tuberculosis household contacts with latent M. tuberculosis infection in a tuberculosis-endemic setting in Kenya. The M. tuberculosis–specific T cell response spectrum assay further enhances the immunological toolkit available for evaluating M. tuberculosis–specific T cell responses across different states of M. tuberculosis infection, and can be readily implemented in resource-limited settings. Moreover, application of the assay to longitudinal cohorts will facilitate evaluation of treatment- or vaccine-induced changes in the breadth and specificity of Ag-specific T cell responses, as well as identification of M. tuberculosis–specific T cell responses associated with M. tuberculosis infection outcomes.
Building a Bridge to Nowhere: Morris, the Education of Desire, and the Party of Utopia
Authors: Allison Mark 
Published: March 2018

ABSTRACT
Is a utopian text best understood as a blueprint for building a better society or as a catalyst for educating the desire of its readers? Since Miguel Abensour's interpretation of News from Nowhere, scholars have favored the latter view. This article contends, however, that the “catalytic” approach to utopian texts created an antinomy within utopian studies. When William Morris composed Nowhere, he was confronting a practical manifestation of the same antinomy. Consequently, studying Morris's utopia sheds valuable light on this methodological problem. This focus also reveals Nowhere's governing metaphor—the bridge—and suggests the significance of Morris's neglected contemporaneous lecture “How Shall We Live Then?” This article concludes that attention to the programmatic and rhetorical content of utopian texts is necessary to balance the dominant emphasis on utopia as an impulse and pedagogical process.