bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polysulfonylamine, CLXVII [1]. Wasserstoffbrücken in kristallinen Onium-dimesylamiden: Ein robustes Dreipunktmuster als Bestandteil eines 2D-, eines zweifach verwobenen 2D- und eines 3D-Wasserstoffbrücken-Netzwerks / Polysulfonylamines, CLXVII [1]. Hydrogen Bonding in Crystalline Onium Dimesylamides: A Robust Three-Point Pattern Integrated into a 2D, a Twofold Interwoven 2D, or a 3D Hydrogen-Bond Network
Authors: Wijaya Karna , Moers Oliver , Blaschette Armand , Jones Peter G. 
Published: August 2018

Abstract
As an exercise in crystal engineering, preparations and low-temperature X-ray structures are reported for three ionic solids of general formula BH+(MeSO2)2N−, where BH+ is 2,4,6- triaminopyrimidinium (compound 1, triclinic, space group P1, Z = 2), 2,6-diaminopyridinium (2, monoclinic, C2/c, Z = 8), or 2,4-diaminopyrimidin-6(1H)-on-3-ium (3, monoclinic, P21/c, Z = 4). As a common feature, the onium cations in question exhibit a trifunctional hydrogen-bond donor sequence H-N-C-N(H)-C-N-H that is complementary to a W-shaped O-S-N-S-O fragment of the anion. Consequently, each structure displays a [DDD:AAA] three-point hydrogen-bond pattern formed by two lateral N-H···O bonds and a central N-H···N interaction. This grouping is integrated as a robust supramolecular synthon into two-dimensional (1, 2) or three-dimensional (3) hydrogen-bond networks, in which all good donors and all good acceptors are involved (excepting one S=O group in 2). In structure 1, the approximately planar cation-anion layers are perfect mosaics composed of 6-membered pyrimidine heterocycles and seven crystallographically independent types of 8-, 10-, 12- or 24-membered rings based upon hydrogen bonding. In contrast, the corresponding layers in structure 2 are marred by large 40-membered voids; in order to achieve dense packing, the imperfect layers adopt a strongly corrugated shape and interpenetrate to form twofold interwoven and nearly planar double-layers. Each structure features close C-H···O contacts consistent with weak hydrogen bonding; in the layer structures 1 and 2, some of these interactions serve as links between adjacent or interwoven layers.
Molecular Structure and Reactivity of Tri(1-cyclohepta-2,4,6-trienyl)amine, N(C7H7)3
Authors: Herberhold Max , Liu Jinnan , Milius Wolfgang 
Published: August 2018

Abstract
Compared with the tertiary phosphane P(C7H7)3 (1), the amine N(C7H7)3 (2) possesses the structure of a flattened trigonal pyramid with a sum of CNC angles of 350.0° (cf. 300.2° (av.) in 1). The heteroatom (with the lone pair) is situated 27.0 pm above the C3 basal plane in 2, but 86.4 pm in 1. The amines N(C7H7)3 (2), NH(C7H7)2 (2a) and N(Ph)(C7H7)2 (2b) react with tropylium tetrafluoroborate, [C7H7]BF4, to give N-tropylidene-(1-cyclohepta-2,4,6-trienyl)-immonium tetrafluoroborates, [(C7H6)N(R)(C7H7)]BF4 3 (R = H, from 2 and 2a), 4 (R = Ph, from 2b), which have been characterized by their IR and NMR (1H, 13C) spectra.
Synthese und Kristallstrukturanalyse eines 2,4-Diaryl-2,3-dihydro-1H-1,5-benzodiazepins / Synthesis and Crystal Structure Analysis of a 2,4-Diaryl-2,3-dihydro-1H-1,5-benzodiazepine
Authors: Hormaza Angelina , Schollmeyer Dieter , Meier Herbert 
Published: August 2018

Abstract
The enone unit of chalcones is a synthetically valuable substructure for the formation of heterocycles. Whereas propoxy groups as solubilizing side chains on the phenyl groups do not much affect the generation of pyrazole and pyridine rings, they reduce significantly the yield of the diazepine ring system 4. We attribute this effect to the large twist angles between the ring planes, which are demonstrated by a crystal structure analysis.
Structure of trans-Isoshinanolone in the Crystal and in Solution
Authors: Bringmann Gerhard , Pfeifer Robert-Michael , Breuning Matthias , Reichert Matthias , Messer Kim , Schraut Michaela , Tóth Gabor 
Published: August 2018

Abstract
The first X-ray structure analysis of authentic, not derivatized (racemic) trans-isoshinanolone, a wide-spread acetogenic tetralone, is described. In the crystal, two slightly different conformers are found, along with the corresponding enantiomers. The ‘homomeric’ conformers differ by their H-bonding interactions with the respective neighboring molecules. Rows of a single enantiomeric species, but with the two conformers linked ‘head-to-head’, ‘tail-to-tail’, are surrounded by four analogous rows of the corresponding enantiomers. Apparently the interactions between these heterochiral rows are the reason for the enhanced crystallization tendency of the racemate as compared to that of enantiomerically pure isoshinanolone. The structures in the crystal are compared with those calculated (gas phase) and with the structure in solution.
Fascicularones C and D, Tricyclo[5.4.0.02.5]undecane Sesquiterpenoids from the Liquid Culture of Naematoloma fasciculare
Authors: Shiono Yoshihito , Wakamatsu Hiroko , Murayama Tetsuya , Ikeda Michimasa 
Published: August 2018

Abstract
Two novel sesquiterpenoids of tricyclo[5.4.0.02.5]undecane skeleton, fascicularones C (5) and D (6) have been isolated from liquid culture of a poisonous mushroom, Naematoloma fasciculare. Their structures were elucidated on the basis of spectroscopic methods. Compounds 5 and 6 promoted radicle elongation of lettuce seedling.
Synthesis of the Four Diastereoisomers of the N-Terminal Amino Acids of Nikkomycins via Aminoalkylation with Preformed Ternary Iminium Salts
Authors: Delbos-Krampe Jeanne , Risch Nikolaus , Flörke Ulrich 
Published: August 2018

Abstract
An efficient and convenient two step synthesis of each of the four possible diastereoisomers of the N-terminal amino acid component of nikkomycins is described. We first synthesized α-amino-β-oxo acids by aminoalkylation of ketones with iminium salts. The second step using Pearlman’s catalyst gave directly nonnatural and natural precursors 13 - 16 of nikkomycins 1 which were easily separated by chromatography on silica gel.
A New Efficient Synthesis of Substituted Luminols Using Multicomponent Reactions
Authors: Neumann Helfried , Klaus Stefan , Klawonn Markus , Strübing Dirk , Hübner Sandra , Gördes Dirk , Wangelin Axel Jacobi von , Lalk Michael , Beller Matthias 
Published: August 2018

Abstract
A new general synthesis of substituted luminols (5-amino-2,3-dihydrophthalazine-1,4-diones) is presented. Diversely substituted luminol derivatives can be synthesized in three steps. The products are of interest as new materials, which exhibit chemiluminescence.
Eine neue Modifikation von Lanthanmonogermanid – lT-LaGe /A New Modification of Lanthanummonogermanide – lT-LaGe
Authors: Mattausch Hansjürgen , Simon Arndt 
Published: August 2018

Abstract
Single crystals of the low temperature modification of LaGe are obtained as a byproduct in the reaction of La metal, LaBr3 and Ge powder at 1000 °C as silver colored, moisture sensitive needles. lT-LaGe crystallizes in space group Cmcm with a = 4.5590(10), b = 13.766(2), c = 6.745(2)Å . The Ge atoms form cis-trans-cis-trans-chains with dGe−Ge = 2.621(1) and 2.799(1) Å in contrast to Ge zigzag chains found in the high temperature modification of LaGe crystallizing in the FeB structure type. In both structures the Ge atoms are surrounded by trigonal prisms of lanthanum atoms with CN = 6+1 but different connection of the prisms.
Reaction of N1,N2-Diarylamidines with 2,3-Diphenylcyclopropenone
Authors: Gomaa Mohsen Abdel-Motaal 
Published: August 2018

Abstract
Reaction of N1,N2-diarylacetamidines 1a - c with 2,3-diphenylcyclopropenone 2 led to formation of addition products 2-methyl-1-aryl-2-arylamino-4,5-diphenyl-1,2-dihydro-3H-pyrrol-3-ones 3a - c. While N1,N2-diarylformamidines 1d - f reacted with 2,3-diphenylcyclopropenone 2 to afford 3-aryl-(N-4-arylformamidoyl)amino-2,3-diphenyl propionic acids 7a - c.
The Synthesis, Crystal Structure and Spectroscopic Properties of a Dinuclear μ–Pyrazolato–N,N’–Bridged Dinickel(II) Complex of 1,3–Bis(salicylideneamino)propan–2–ol
Authors: Zeyrek C. T. , Elmali A. , Elerman Y. 
Published: August 2018

Abstract
The title compound [Ni2(L)(3,5 prz)], prz = pyrazolate with the formally pentadentate ligand L = 1,3-bis(salicylideneamino)propan-2-olate, was synthesized and identified using elemental analysis and IR spectroscopy. It crystallizes in the monoclinic space group P21/c with cell parameters a = 29.873(4), b = 11.131(2), c = 13.166(3) Å , β = 107.770(10)°, V = 4169.0(13) Å3, Z = 4, Dcal = 1.618 Mg/m3. The nickel ions are bridged by the alkoxo group of the ligand and the N atoms of the μ-pyrazolate group. Each nickel(II) ion is coordinated by two N atoms and two O atoms, forming a square with trans-N2O2 geometry. The Ni···Ni distance and the Ni−O−Ni angle are 3.371(1) Å and 126.4(1)°, respectively.
Ring Size Influence on the Cyclocondensation Mode of GABA – Nitrile Imine Adducts
Authors: Thaher Bassam A. Abu , Zahra Jalal A. , El-Abadelah Mustafa M. , Voelter W. 
Published: August 2018

Abstract
γ -Aminobutyric acid (GABA) adds onto nitrile imine 1,3-dipolar species (generated in situ from their N-arylhydrazonoyl chloride precursors 1a-c ) to deliver the corresponding acyclic amidrazone adducts 10a-c. In the presence of 1,1’-carbonyldiimidazole, the latter adducts undergo cyclocondensation involving the activated carboxyl and the amidrazone-CH2NH groups to afford the respective N-[1-(arylhydrazono)-2-oxopropan-1-yl] pyrrolidin-2-ones (11a-c). The constitution of 10 and 11 is evidenced from analytical and spectral (IR , MS and NMR) data.
A Second Modification of Mercury(I) Orthoarsenate(V): Preparation and Crystal Structure of β-(Hg2)3(AsO4)2
Authors: Weil Matthias 
Published: August 2018

Abstract
Light-yellow crystals of a second modification of mercury(I) orthoarsenate(V), β-(Hg2)3(AsO4)2, were obtained during a diffusion-controlled precipitation reaction starting from diluted solutions of Hg2(NO3)2, Hg(NO3)2, and H3AsO4. The crystal structure was determined from a single crystal X-ray diffraction data set. The previously reported crystal structure of synthetic chursinite, α-(Hg2)3(AsO4)2, has also been re-investigated and refined with better accuracy and precision. Both phases crystallize in space group type P21/c (no. 14) [α- (β -): Z = 2 (4), a = 8.7915(6) (10.2034(18)), b = 5.0699(4) (8.5875(14)), c = 15.6839(10) (13.5172(19)) Å , β = 128.761(1) (101.016(3))°, 1661 (3528) structure factors, 74 (146) parameters, RF2 > 2σ (F2)] = 0.0195 (0.0492)] and are made up from Hg2
2+ dumbbells and AsO4
3− tetrahedra as the main building units, but the topologies of the structures are quite different.
Enamines in Heterocyclic Synthesis: A Route to 4-Substituted Pyrazoles and Condensed Pyrazoles
Authors: Hassaneen Huwaida M. E. , Hassaneen Hamdi M. , Elnagdi Mohamed H. 
Published: August 2018

Abstract
The reaction of nitrile imines, generated in situ, from hydrazonoyl halides 3a - e with enamines 2a - c affords pyrazoles 8a - g. These pyrazoles have been used to prepare condensed pyrazoles.
Experimental Gas Phase 1H NMR Spectra and Basis Set Dependence of ab initio GIAOMO Calculations of 1H and 13C NMR Absolute Shieldings and Chemical Shifts of Small Hydrocarbons
Authors: Zuschneid Thomas , Fischer Holger , Handel Thomas , Albert Klaus , Häfelinger Günter 
Published: August 2018

Abstract
High-resolution gas phase measurements of 1H NMR spectra at 400 MHz and atmospheric pressure of seven small hydrocarbons are presented. The developed new method and the experimental set-up are described. Ab initio GIAO MO calculations of 1H and 13C NMR absolute shieldings on the HF, MP2 and B3LYP levels using 25 standard gaussian basis sets are reported for these hydrocarbons, based on experimental re distances. The measured gas phase 1H chemical shifts have been converted to an absolute σ0 shielding scale by use of the literature shielding of methane. These and gas phase 13C literature values have been transferred with literature ZPV data to estimated σe
exp shieldings which are used to evaluate the basis set dependence of the calculated σe shieldings utilizing linear least squares regressions. Exponential extrapolations of Dunning basis set calculations allow the determination of basis set limits for 1H and 13C shieldings.

1H and 13C chemical shifts have been derived from the HF calculated shieldings with shieldings of TMS which has been geometry optimized and GIAO calculated in each basis. Standard deviations (esd) as low as 0.09 ppm for 1H and 0.76 ppm for 13C calculations have been obtained.
The statistically best basis set for simultaneous calculation of 1H and 13C absolute shieldings or relative shifts is 6-311G* within the HF and B3LYP methods. Aiming for highest accuracy and precision, 1H and 13C have to be treated separately. In this case, best results are obtained using MP2/6-311G** or higher for 1H shieldings and MP2/cc-pVTZ for 13C shieldings.
The Modulated Structure of SrAuSn2
Authors: Esmailzadeh Saeid , Hoffmann Rolf-Dieter , Pöttgen Rainer 
Published: August 2018

Abstract
The ternary stannide SrAuSn2 was synthesized by induction melting of the elements under an argon atmosphere in a sealed niobium ampoule in a water-cooled sample chamber of a high-frequency furnace. The structure of SrAuSn2 was investigated by X-ray powder and single crystal diffraction. It was found to be favourable to describe as a commensurately modulated structure. The 3+1 dimensional superspace group symmetry P : Cmcm(α, 0, 0) : 0s0 with the unit cell dimensions a = 460.20(14), b = 2038.8(8), c = 460.34(19) pm and the modulation wave vector q =¼ [100]*. The Sn1 atoms were those with the strongest modulation while the rest of the atoms showed rather small deviations from the average structure. The SrAuSn2 structure is closely related to the CeNiSi2 type. Geometrically these structures are built up from distorted ThCr2Si2 and AlB2 slabs. The gold atoms are located in the ThCr2Si2 slab. They have a distorted square pyramidal tin coordination at Au-Sn distances ranging from 266 to 294 pm. These pyramids are condensed via common edges forming two-dimensional layers. The latter are condensed via the Sn1 atoms within the AlB2 slabs that form one-dimensional zigzag chains with Sn1-Sn1 distances ranging from 282 to 288 pm. These chains show the strong modulations. Together, the gold and tin atoms build up a three-dimensional [AuSn2] network, in which the strontium atoms fill distorted hexagonal channels.
Synthesis and Crystal Structure Analysis of C60 Fulleride Dianions in Solvates of [A([2.2.2]crypt)]2[C60] (A = K, Rb, Cs)
Authors: Hoffmann Stephan D. , Fässler Thomas F. 
Published: August 2018

Abstract
Reduction of C60 with the alkali metals A = K, Rb and Cs in tetrahydrofuran as a solvent and addition of [2.2.2]crypt [1], dimethylformamide and cyclohexane lead to the formation of crystalline samples of [A([2.2.2]crypt)]2[C60](C6H12)2(C3H7NO)2(C4H8O)2 (A = K, Rb, Cs) 1a, 1b and 1c as major fractions. As a by-product of compound 1a, a second minor fraction containing [K([2.2.2]crypt)]2[C60](C3H7NO)4 2 was obtained. The structures of the four compounds have been determined by single-crystal X-ray analyses. The [C60]2− dianions are predominantly ordered. As the main structural motif the structures of compounds 1a, 1b and 1c contain pseudo-hexagonal layers of [C60]2− dianions. Compound 1c contains a rare example of a Cs+ sequestering [2.2.2]crypt molecule. The packing of the ionic units in compound 2 also shows layers of distorted hexagons formed by [C60]2− dianions which arranged in pairs with short contacts of 10.3 Å between their centers of gravity.
Comparative Study of Extraction Techniques with Ammonia or Methanol/Water for the Isolation of Ginsenosides Using HPLC/MS
Authors: Nolte Jürgen , Nigge Walter , Hohaus Eberhard , Cho In-Ho , Lentz Harro 
Published: August 2018

Roots of ginseng plants have been extracted with liquid ammonia or methanol/water (60:40 v/v). The extracts were characterized by means of a gradient HPLC/MS method and the results were compared with each other. The ginsenosides Rb1, Rb2, Rc, Rd, Re, Rf, Rg1 and Ro including the malonyl ginsenosides m-Rb1, m-Rb2, m-Rc and m-Rd could be identified. Contrary to previous reports suggesting that during the extraction with liquid ammonia malonyl ginsenosides are totally converted to neutral ginsenosides, it could now be demonstrated by use of mass spectrometry that even after an extraction time of 4 h malonyl ginsenosides can be detected. However, the amount of malonyl ginsenosides was reduced by about one order of magnitude.
The neutral ginsenosides were not changed by liquid ammonia. The mass spectrometric detection has been performed by use of the quasi-molecule ion [M+Na]+ and some specific fragment ions.
Synthesis of Dimethyl 1-(Hetero)aryl-4-oxo-1,4-dihydropyridazine- 3,5-dicarboxylates from Dimethyl 3-Oxopentane-1,5-dioates
Authors: Pahovnik David , Uršič Uroš , Grošelj Uroš , Meden Anton , Svete Jurij , Stanovnik Branko 
Published: August 2018

Abstract
Dimethyl 3-oxopentane-1,5-dioate (dimethyl acetone-1,3-dicarboxylate) (1) was transformed first with (hetero)arenediazonium salts 3a - j into dimethyl 2-[(hetero)arylhydrazono]pentane-1,5-dioates 4a - j followed by reaction with N,N-dimethylformamide dimethylacetal (DMFDMA) to afford, without isolation of intermediates 5a - j, dimethyl 1-(hetero)aryl-4-oxo-1,4-dihydropyridazine-3,5- dicarboxylates 6a - j. An alternative method represents transformation of 1 with DMFDMA into dimethyl 2-[(dimethylamino)methylidene]-3-oxopentane-1,5-dioate (7) followed by treatment with (hetero)arenediazonium salts 3a - c, j to give pyridazine derivatives 6a - c,j.
cis/trans Isomers of Dimeric Dialkylaluminum and Dialkylgallium Hydrazides
Authors: Uhl Werner , Vogelpohl Andreas 
Published: August 2018

Abstract
The reaction of diethylaluminum hydride with the hydrazine derivatives 1-aminopyrrole and 1- aminopiperidine afforded the corresponding dialkylaluminum hydrazides (1 and 2) by the release of elemental hydrogen. Both products are dimeric in the solid state. While 1 adopts a cis arrangement of the pyrrole groups, a trans configuration was determined for the piperidine compound 2. Only 1 gives an equilibrium mixture of cis and trans isomers in solution. Similar compounds (3 and 4) were obtained by the treatment of the same hydrazines with di(tert-butyl)gallium hydride. Both products exhibit the trans configuration in the solid state, but interestingly only the piperidine derivative 4 shows a cis/trans equilibrium in solution.
On the Photocatalytic Performance of Indium Tantalate and its Modifications
Authors: Douiheche Maoiheb , Haberkorn Robert , Beck Horst P 
Published: August 2018

Abstract
The photocatalytic activity of InTaO4 has been studied regarding the effect of a substitution of In by Ni, of the performance of NiO as well as Ag2O as co-catalysts, and especially of the products of different methods of preparation (solid state reaction and/or sol-gel process) and their particle sizes. Solid state reactions and sol-gel procedures were used to synthesise different products for the catalytic reaction in a reactor vessel equipped with amercury UV lamp. The optical properties and the band gap values of the different products were evaluated by reflectance spectroscopy, and the microstructure parameters of the crystalline products were determined by an elaborate profile analysis of the X-ray diagrams. The evolution of H2 and O2 under irradiation was quantified by a GC setup. The causes for the deviations of the performance of these catalysts from the values reported elsewhere are discussed.
Self-assembly Through Non-coordinating Intermolecular Forces, Part 2 [1]. Synthesis, Crystal Structure and Packing of [Cu2(μ-phthalazine)3(phthalazine)2][CF3SO3]2
Authors: Plasseraud Laurent , Cattey Hélène , Richard Philippe 
Published: August 2018

Abstract
Treatment of the copper(I) trifluoromethanesulphonate toluene complex {[Cu(CF3SO3)]2 · C6H5Me} (1) with phthalazine (phtz, C8H6N2) in dichloromethane-acetonitrile solution yielded, via the bis(acetonitrile)tris(μ-phthalazine)dicopper(I) trifluoromethanesulphonate intermediate (2), the novel bis(phthalazine)tris(μ-phthalazine)dicopper(I) trifluoromethanesulphonate salt (3). Compound 3 was completely characterised and the molecular structure determined by single-crystal X-ray diffraction. Complex 3 crystallises in the monoclinic system, space group C2/c, with a = 26.9527(10), b = 10.9558(7), c = 19.2104(10) Å , β = 127.268(2)◦, V = 4514.3(4) Å3 and Z = 4. The copper(I) coordination geometry is tetrahedral, each copper centre being linked to four phthalazine molecules. Dicationic units of 3 which present an unusual paddle wheel-like shape constitute appropriate organometallic building blocks for the construction of a supramolecular solid-state architecture. The analysis of the packing of the molecules of 3 in the crystal revealed an unprecedented 2-dimensional network, resulting from intermolecular π-π and electrostatic interactions.
Cooperative Effects in Aminothiols: Acid-Base Equilibria and the Molecular Structure of 2-(N, N-Dimethylaminomethyl)thiophenol
Authors: Fleischer Holger , Schollmeyer Dieter 
Published: August 2018

Abstract
2-(N,N-Dimethylaminomethyl)thiophenol, (1, HL), is present as a non-zwitterionic aminothiol in the solid state, exhibiting an intramolecular S-H···N hydrogen bond. The S···N distances of the two independent molecules in the asymmetric unit are 2.929(10) and 3.050(10) Å. This structural feature is also present in an ab initio (MP2/6-31G*) optimized molecular structure. The investigation of the hydrogen bond by ab initio methods supports an n(N)-σ *(S-H) interaction as the reason for this bond type. On the basis of data from potentiometric acid-base titrations of a 0.01 M aqueous solution of [H2L]Cl with a 0.1 M aqueous solution of sodium hydroxide, values of 4.09±0.01 and 11.50±0.01 were obtained for pKa1 and pKa2 of [H2L]+. pKa1 is much smaller than pKa of thiophenol while pKa2 is bigger than pKa of benzyldimethylamine. The increased difference between pKa1 and pKa2 is attributed to the stabilization of HL by the intramolecular S-H···N hydrogen bond.
Influence of Hydrogen Bonding Interactions on the Conformation of Ribbon-like Zn(II) Complexes Bridged by Molybdates
Authors: Hua Tianhui , You Wansheng , Daia Limei , Zhao Yi , Fang Yong , Zheng Xuefang 
Published: August 2018

Abstract
The complexes [Zn(dpa)MoO4] (1) and [Zn(dpa)MoO4]·0.5H2O (20.5H2O) (dpa = 2,2'-dipyrid- ylamine) were synthesized hydrothermally. Single crystal structure analyses indicate that 1 and 2 are conformational isomers. They both consist of binuclear units of edge-sharing {ZnN2O3} trigonal bipyramids bridged by pairs of bidentate briding {MoO4}2- anions into a one-dimensional ribbon, but their orientations of the terminal O atoms of the {MoO4}2- anions are different. In 1 and 2, the ribbon-like chains are connected into a 2D network via hydrogen bonding interactions between the central N-H portions of the dpa molecules and the terminal O atoms of {MoO4} tetrahedra. For 2, in addition, the hydrogen bonding interactions between the crystal water molecules and the terminal O atoms of {MoO4} tetrahedra join the 2D layers into a 3D architecture. They play an important role not only in constructing the 3D architecture, but also in the conformational stability.
Convenient Synthesis and Evaluation of Biological Activity of Benzyl (2S)-2-[(R)-1-hydroxy-2-oxo-(1-phenethyl)prop-3-ylcarbamoyl]- 4-oxopiperidine- (or -4-oxopyrrolidine)-1-carboxylate as Novel Histone Deacetylase Inhibitors
Authors: Oh Seikwan , Moon Hyung-In , Jung Jae-Chul , Avery Mitchell A. 
Published: August 2018

Abstract
A simple synthesis, involving a key coupling reaction, and the biological activity of the title compounds 16 and 17 are described. The key fragments are the amine·HCl salt 6 and the acids 9 and 13, which were smoothly coupled by using ethyl(dimethylaminopropyl)carbodiimide (EDCI) and 1- hydroxybenzotriazole (HOBt) in high yield.We have found that the in vitro growth inhibitory potency of the new compounds 16 and 17 exhibits good histone deacetylase (HDAC) activity.