bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early-type galaxy density profiles from IllustrisTNG – II. Evolutionary trend of the total density profile
Authors: Wang Yunchong , Vogelsberger Mark , Xu Dandan , Shen Xuejian , Mao Shude , Barnes David , Li Hui , Marinacci Federico , Torrey Paul , Springel Volker , Hernquist Lars 
Published: October 2019

ABSTRACT
We study the evolutionary trend of the total density profile of early-type galaxies (ETGs) in IllustrisTNG. To this end, we trace ETGs from z = 0 to 4 and measure the power-law slope γ′ of the total density profile for their main progenitors. We find that their slopes γ′ steepen on average during z ∼ 4–2, then becoming shallower until z = 1, after which they remain almost constant, aside from a residual trend of becoming shallower towards z = 0. We also compare to a statistical sample of ETGs at different redshifts, selected based on their luminosity profiles and stellar masses. Due to different selection effects, the average slopes of the statistical samples follow a modified evolutionary trend. They monotonically decrease since z = 3, and after z ≈ 1, they remain nearly invariant with a mild increase towards z = 0. These evolutionary trends are mass dependent for both samples, with low-mass galaxies having in general steeper slopes than their more massive counterparts. Galaxies that transitioned to ETGs more recently have steeper mean slopes as they tend to be smaller and more compact at any given redshift. By analysing the impact of mergers and AGN feedback on the progenitors’ evolution, we conjecture a multiphase path leading to isothermality in ETGs: dissipation associated with rapid wet mergers tends to steepen γ′ from z = 4 to 2, whereas subsequent AGN feedback (especially in the kinetic mode) makes γ′ shallower again from z = 2 to 1. Afterwards, passive evolution from z = 1 to 0, mainly through gas-poor mergers, mildly decreases γ′ and maintains the overall mass distribution close to isothermal.
Optimizing neural network techniques in classifying Fermi-LAT gamma-ray sources
Authors: Kovačević M , Chiaro G , Cutini S , Tosti G 
Published: October 2019

ABSTRACTMachine learning is an automatic technique that is revolutionizing scientific research, with innovative applications and wide use in astrophysics. The aim of this study was to develop an optimized version of an Artificial Neural Network machine learning method for classifying blazar candidates of uncertain type detected by the Fermi Large Area Telescope γ-ray instrument. The final result of this study increased the classification performance by about 80 ${{\ \rm per\ cent}}$ with respect to previous method, leaving only 15 unclassified blazars out of 573 blazar candidates of uncertain type listed in the LAT 4-year Source Catalog.
The Pristine survey – VII. A cleaner view of the Galactic outer halo using blue horizontal branch stars
Authors: Starkenburg Else , Youakim Kris , Martin Nicolas , Thomas Guillaume , Aguado David S , Arentsen Anke , Carlberg Raymond G , González Hernández Jonay I , Ibata Rodrigo , Longeard Nicolas , McConnachie Alan W , Navarro Julio , Sánchez-Janssen Rubén , Venn Kim A 
Published: October 2019

ABSTRACT
We use the Pristine survey CaHK narrow-band photometry, combined with the Sloan Digital Sky Survey (SDSS)ugr photometry, to provide a cleaner sample of blue horizontal branch stars in the Galactic halo out to large distances. We demonstrate a completeness of 91 per cent and a purity of 93 per cent with respect to available spectroscopic classifications. We subsequently use our new clean sample of these standard candles to investigate the substructure in the Galactic halo over the Pristine footprint. Among other features, this allows for a careful tracing of multiple parts of the Sagittarius stream, providing a measurement independent from other tracers used and reaching larger distances. Moreover, we demonstrate with this clean and complete sample that the halo follows a density profile with a negative power-law slope of 3.5–4.0. As the relatively shallow SDSS u band is the limiting factor in this technique, we foresee large potential for combining Pristine survey photometry with the much deeper u-band photometry from the Canada–France–Imaging Survey.
The Impact of Intra-Arterial Papaverine-Hydrochloride on Cerebral Metabolism and Oxygenation for Treatment of Delayed-Onset Post-Subarachnoid Hemorrhage Vasospasm
Authors: Hosmann Arthur , Wang Wei-te , Dodier Philippe , Bavinzski Gerhard , Engel Adrian , Herta Johannes , Plöchl Walter , Reinprecht Andrea , Gruber Andreas 
Published: October 2019

Abstract

BACKGROUND
Delayed posthemorrhagic vasospasm remains among the major complications after aneurysmal subarachnoid hemorrhage (SAH) and can result in devastating ischemic strokes. As rescue therapy, neurointerventional procedures are used for selective vasodilatation.

OBJECTIVE
To investigate the effects of intra-arterial papaverine-hydrochloride on cerebral metabolism and oxygenation.

METHODS
A total of 10 consecutive patients, suffering from severe aneurysmal SAH were prospectively included. Patients were under continuous multimodality neuromonitoring and required intra-arterial papaverine-hydrochloride for vasospasm unresponsive to hypertensive therapy. Cerebral metabolism (microdialysis), brain tissue oxygen tension (ptiO2), intracranial pressure (ICP), and cerebral perfusion pressure (CPP) were analyzed for a period of 12 h following intervention.

RESULTS
A median dose of 125 mg papaverine-hydrochloride was administered ipsilateral to the multimodality probe. Angiographic improvement of cerebral vasospasm was observed in 80% of patients. During intervention, a significant elevation of ICP (13.7 ± 5.2 mmHg) and the lactate-pyruvate ratio (LPR) (54.2 ± 15.5) was observed, whereas a decrease in cerebral glucose (0.9 ± 0.5 mmol/L) occurred. Within an hour, an increase of cerebral lactate (5.0 ± 2.0 mmol/L) and glycerol (104.4 ± 89.8 μmol/L) as well as a decrease of glucose (0.9 ± 0.4 mmol/L) were measured. In 2 to 5 h after treatment, the LPR significantly decreased (pretreatment: 39.3 ± 15.3, to lowest 30.5 ± 6.7). Cerebral pyruvate levels increased in 1 to 10 h (pretreatment: 100.1 ± 33.1 μmol/L, to highest 141.4 ± 33.7 μmol/L) after intervention. No significant changes in ptiO2 or CPP occurred.

CONCLUSION
The initial detrimental effects of the endovascular procedure itself were outweighed by an improved cerebral metabolism within 10 h thereafter. As the effect was very limited, repeated interventions or continuous application should be considered.
Pediatric weight bias in prehealth profession undergraduates: an idiographic approach
Authors: Basch Molly C , Mayer-Brown Sarah , Robinson Michael E , Janicke David M 
Published: October 2019

AbstractBias toward individuals with overweight/obesity (OV/OB) exists among health professionals and trainees with the potential to affect the quality of healthcare interactions. Given most research is adult-focused, this study aimed to examine the influence of weight status on clinical judgments in a pediatric context. Sixteen virtual human scenes representing hypothetical medical encounters of pediatric patients and their mothers were presented to prehealth profession undergraduates (n = 92). Characteristics, or cues, of patient and mother weight status (healthy weight vs. obese) and dyad race (Caucasian vs. African American) were manipulated across scenes. Participants provided ratings for assessment questions, including perceived treatment adherence and responsibility for health, for each scene. Data were examined via idiographic (i.e., individual-level) analysis, which involved generation of separate multiple regressions per participant per assessment question to capture the influence of the cues on participants' ratings. Results represent secondary outcomes from another study published elsewhere. Current analyses revealed that 12%–22% of participants relied on cues of weight status when making assessments about patient and mother adherence and responsibility for health. The majority of these participants equated higher weight status with poorer anticipated treatment adherence and greater health responsibility. Results suggest that the weight status of pediatric patients and their mothers' plays a considerable role in prehealth profession undergraduates' clinical judgments, with the future potential to affect disparities in pediatric care. This study highlights the importance of considering child and maternal factors and utilizing a novel approach that may serve as a model for further investigation of this issue.
Nanocrystalline-Coated Silver Dressings for Patients with Type 2 Diabetes after Surgical Coronary Revascularization
Authors: Parys Monika , Jaźwiec Tomasz , Kowalczuk-Wieteska Anetta , Majchrzyk Iwona , Gancarczyk Halina , Skoczeń Aleksandra , Kumor Julita , Mijacz Monika , Kubacki Krzysztof , Zembala Michał Oskar , Zembala Marian 
Published: October 2019

ABSTRACT

OBJECTIVE
To assess the suitability of nanocrystalline-coated silver dressings versus standard wound dressings in patients with type 2 diabetes after coronary revascularization.

METHODS
The study involved 194 patients who were divided into two homogeneous groups. The control group (n = 97) received a standard sterile dressing. The intervention group (n = 97) received silver dressings. Glycosylated hemoglobin, fructosamine, and creatinine were assessed in all patients. The emergence of superficial wound infection within 30 days was the primary endpoint of the study, and deep wound infections were a secondary endpoint.

MAIN RESULTS
Superficial wound infections were documented in 26 patients: 11 patients in the study group and 15 in the control group. There were no statistically significant differences between the analyzed groups regarding the occurrence of the primary endpoint. No deep wound infections were found in either the study or control group.

CONCLUSIONS
The frequency of sternotomy wound infection in patients with type 2 diabetes is comparable between patients treated with traditional dressings and those receiving silver dressings; therefore, to maximize cost savings, providers should consider using standard wound dressings in this patient population.
Validated 60-Second General Foot Screen: A Pilot Trial and Guide to Diagnoses and Treatment
Authors: Sibbald R. Gary , Maliyar Khalad , Persaud-Jaimangal Reneeka , Elliott James A. , Brandon Alisa , Kotru Bharat , Armstrong David G. 
Published: October 2019

ABSTRACT
Foot health is important to overall patient health. Early diagnosis and treatment of diabetes, neuropathy, fungal foot infections, foot deformity, and vascular disease/lower leg edema can improve patient quality of life. One way to achieve this is effective screening. To this end, researchers piloted a validated 10-item screening tool to assess foot health on 120 patients; 74.17% had at least one positive abnormality, demonstrating the critical importance of these early findings. Only 25.83% of individuals had completely low-risk feet. This easy-to-use tool can assist healthcare professionals in the recognition and treatment of common foot problems. The article also outlines the early signs of disease by screening item and provides a guide to treatment to enable effective prevention and quality care.

GENERAL PURPOSE
To provide information on a 60-second General Foot Screen to assist in the prevention and/or identification and management of common foot problems.

TARGET AUDIENCE
This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

LEARNING OBJECTIVES/OUTCOMES
After participating in this educational activity, the participant should be better able to:
1. Use the 60-second General Foot Screen to assist healthcare professionals in the recognition of common foot problems.
2. Identify risk factors, causes, and treatment of selected foot problems.
Intravenous Artesunate for Imported Severe Malaria in Children Treated in Four Tertiary Care Centers in Germany
Authors: Bélard Sabine , Brand Judith , Schulze-Sturm Ulf , Janda Ales , von Both Ulrich , Tacoli Costanza , Alberer Martin , Kempf Caroline , Stegemann Miriam S. , Krüger Renate , Varnholt Verena , Blohm Martin , Reiter Karl , Zoller Thomas , Suttorp Norbert , Mall Marcus , von Bernuth Horst , Gratopp Alexander , Hübner Johannes , Hufnagel Markus , Kobbe Robin , Kurth Florian 
Published: October 2019

Background:
Intravenous artesunate (ivA) is the standard treatment for severe malaria. Data systematically evaluating the use of ivA in pediatric patients outside malaria-endemic regions are limited. The aim of this case series was to summarize efficacy and safety of ivA for imported severe malaria in children in Germany.

Methods:
Our retrospective case series included pediatric patients with imported severe malaria treated with at least 1 dose of ivA (Artesun, Guilin Pharmaceutical; Shanghai, China) at 4 German tertiary care centers. Severe malaria was defined according to World Health Organization criteria.

Results:
Between 2010 and 2018, 14 children with a median [interquartile range (IQR)] age of 6 (1;9.5) years were included. All children were of African descent. All but 2 patients had Plasmodium falciparum malaria; 1 child had P. vivax malaria and 1 child had P. falciparum and P. vivax co-infection. Median (IQR) parasitemia at admission in patients with P. falciparum was 9.5% (3;16.5). Patients were treated with 1–10 [median (IQR) 3 (3;4)] doses ivA. All but one patient received a full course of oral antimalarial treatment. Parasite clearance was achieved within 2–4 days, with the exception of 1 patient with prolonged clearance of peripheral parasitemia. Three patients experienced posttreatment hemolysis but none needed blood transfusion. Otherwise ivA was safe and well tolerated.

Conclusions:
ivA was highly efficacious in this pediatric cohort. We observed episodes of mild to moderate posttreatment hemolysis in approximately one-third of patients. The legal status and usage of potentially lifesaving ivA should be evaluated in Europe.
Clinical value of haptoglobin and soluble CD163 testing for the differential diagnosis of tuberculous and malignant pleural effusions
Authors: Gao Jinying , Song Lei , Li Dan , Peng Liping , Ding Hui 
Published: October 2019

Abstract
This study aims to evaluate the clinical value of haptoglobin (Hp) and sCD163 testing for the differential diagnosis of pleural effusion, and investigate the correlation of Hp and sCD163 with the inflammatory response of the body.
Pleural effusion samples were collected from 78 patients (38 tuberculous pleural effusions [TPE] and 40 malignant pleural effusions [MPE]). The concentrations of Hp and sCD163 in the pleural effusion were measured by enzyme-linked immunosorbent assay (ELISA).
The concentrations of Hp and sCD163 were significantly higher in the TPE group than in the MPE group (P < .05). The sensitivity and specificity of the Hp test for the differential diagnosis of TPE and MPE was 82.4% and 86.1%, respectively (P < .01), while the cut off value was 779.05 ug/mL. Furthermore, the sensitivity and specificity of the sCD163 test for the differential diagnosis of TPE and MPE was 76.3% and 85.0%, respectively (P < .01), while the cut off value was 16,401.11 ng/mL. Moreover, the sensitivity and specificity of the combination of Hp and sCD163 tests for diagnosing TPE was 90.0% and 87.5%, respectively. Hp and IL-1β, TNF-α, CRP and ESR were positively correlated in both the TPE group and MPE group (P < .05). Hp and sCD163 were positively correlated in the TPE group (r = 0.3735, P = .0209), but not in the MPE group (r = 0.22, P = .1684). However, there was no correlation between sCD163 and TNF-α, CRP and ESR in either the TPE group, or the MPE group (P > .05). Furthermore, sCD163 and IL-1β were weakly correlated in the TPE group (r = 0.49, P = .0018), but these had no correlation in the MPE group (r = 0.068, P = .6767).
Hp and sCD163 can be used as biological markers for the differential diagnosis of pleural effusion in clinic, and the level of Hp in pleural effusion may reflect the intensity of inflammation in the body to some extent.
Efficacy of computed tomography in prediction of operability of L5/S1 foraminal stenosis using region of interest
Authors: Shim Dong Woo , Lee Byung Ho , Seo Jiwoon , Hong Hyunjoo , Shin Sung Chul , Kim Hak Sun 
Published: October 2019

Abstract
Symptoms of intervertebral foraminal stenosis are caused by compression of nerve root exiting the intervertebral foramen. Many attempts to measure the size of the neuromuscular exit have been made; however, only a few studies to compare the area differences between foramens by computed tomography (CT) were done. In this retrospective comparative study, we used the region of interest (ROI) in CT to measure and compare the area of intervertebral foramen between the healthy control group and the patient group.
Eighty-one patients who underwent CT of the lumbar spine between May 2014 and December 2017 were enrolled. Using the medical imaging program, the foraminal area between L5 and S1 vertebrae was measured on the sagittal, coronal, and axial planes using ROI. Four groups were established for comparison: those diagnosed with foraminal stenosis by a radiologist and those who were not, those diagnosed with foraminal stenosis by orthopedic surgeons and those who were not. These groups were further divided into subcategories depending on whether the area was operated on for foraminal stenosis. Interobserver and intraobserver agreements were assessed.
The mean age of patients was 56.5 years (range 17–84). The foraminal area of the surgical group on sagittal plane was significantly narrower than the control group (P = .005). However, the difference between the 2 groups on axial and coronal planes was not statistically significant (P > .1). Foraminal area <80 mm2 on sagittal images was a statistically significant risk factor for clinical symptom (P = .028) and that <65 mm2 was a statistically significant risk factor in predicting operability (P = .01). Interobserver and intraobserver agreements were fair to good on axial and coronal planes (about 0.7), whereas the agreements were excellent on sagittal plane (>0.9).
In this study, we proved that measuring the intervertebral foraminal area using the ROI in CT in the lumbar spine is useful for diagnosing L5-S1 foraminal stenosis, especially on sagittal plane. Furthermore, not only does it provide aid in diagnosis, but it also helps predicting the operability of foraminal stenosis.
Vulvar epithelioid leiomyoma with myxoid change
Authors: Jang Si-Hyong , Cho Hyun Deuk , Lee Ji-Hye , Lee Hyun Ju , Hong Soon Auck , Ahn Hyein , Mun Seong Taek , Oh Mee-Hye 
Published: October 2019

Abstract

Rationale:
Smooth muscle tumors of the vulva are infrequent neoplasms with diverse histologic features and unclear biologic behavior. Herein, we report a very rare case of vulvar epithelioid leiomyoma and review of previous reported cases of these tumors. In addition, we have discussed the representative diagnostic criteria of vulvar smooth muscle tumors and prognostic significance of epithelioid morphology.

Patient concerns:
We recently met a 45-year-old woman with complaint of painful vulvar mass.

Interventions:
Excisional biopsy was performed.

Diagnoses:
Pathologic examination revealed a vulvar epithelioid leiomyoma with multinodular growth pattern. Mitotic activity was rare and cellular atypia was not identified. Based on histology and immunohistochemical staining results, the case was diagnosed as vulvar epithelioid leiomyoma.

Outcomes:
After mass excision, the patient was discharged with no complication and there was no evidence recurrence for 6 months.

Lessons:
After reviewing previous papers and diagnostic criterion, we thought that vulvar smooth muscle tumors with predominant epithelioid morphology may be associated with unfavorable prognosis, Therefore, pathologists should examine the epithelioid component in vulvar smooth muscle tumors carefully.
A meta-analysis of cisplatin-based concurrent chemoradiotherapy with or without cetuximab for locoregionally advanced nasopharyngeal carcinoma
Authors: Wang Bi-Cheng , Shi Liang-Liang , Fu Chen , Zhou Hong-Xia , Zhang Zhan-Jie , Ding Qian , Peng Gang 
Published: October 2019

Abstract

Background:
It is unclear whether cetuximab (CTX) plus cisplatin-based concurrent chemoradiotherapy (CCRT) delivers equivalent or improved results over standard CCRT in locoregionally advanced nasopharyngeal carcinoma (NPC).

Methods:
The strategy involved searching the PubMed, Embase, Cochrane Library, and Web of Science. Pooled hazard ratios (HRs) for overall survival (OS), distant metastasis-free survival (DMFS), locoregional relapse-free survival (LRFS), and disease-free survival (DFS), and pooled risk ratios for adverse events were meta-analyzed.

Results:
In all, 1744 patients in 5 clinical trials were included in the analysis. Compared with CCRT group, CTX plus CCRT significantly improved DFS (HR = 0.59, 95% confidence interval [CI]: 0.41–0.86, P = .006) and distant metastasis failure-free survival (HR = 0.54, 95% CI: 0.38–0.76, P = .0004), rather than OS (HR = 0.70, 95% CI: 0.44–1.09, P = .12) and local-regional failure-free survival (HR = 0.82, 95% CI: 0.54–1.22, P = .33).

Conclusions:
CTX plus CCRT might achieve higher DFS and DMFS with no significant difference in OS and LRFS. CTX plus CCRT group was associated with more grade 3-4 skin rash, mucositis and dermatitis. Large randomized trials were urgent to fully explore the usefulness of this treatment in the locally advanced NPC patients.