bluuebunny/crossref_metadata_2025_split huggingface dataset:
A mixed-methods evaluation of a community physical activity program for breast cancer survivors
Authors: Sabiston Catherine M. , Fong Angela J. , O’Loughlin Erin K. , Meterissian Sarkis 
Published: June 2019

Abstract
Background
Given the benefits of physical activity for health and survival, clinicians are seeking opportunities for cancer patients to become more active independent of rehabilitation programs that are small, time-limited, and location specific. This proof-of-concept study evaluated a community-based physical activity program (Curves™) for increasing physical activity among women diagnosed and treated for breast cancer.

Methods
Women were recruited from a breast cancer clinic through physician chart review. In study 1, women (n = 14) received the community physical activity memberships (Curves™), guidelines, and a pedometer. This group was compared to women (n = 16) who received physical activity guidelines and a pedometer on changes in physical activity. In study 2, women (n = 66) completed self-report questionnaires after Curves™ memberships expired to evaluate the program. Study 3 was a qualitative study exploring the benefits and barriers of the physical activity program among women (n = 6) who attended Curves™ regularly.

Results
Provision of memberships to a community-based physical activity program did not improve physical activity levels beyond educational and information resources. However, there are a number of advantages to community-based physical activity programs, and the women offer a number of suggestions for improvements for community physical activity opportunities aimed at breast cancer survivors.

Conclusions
Women-only community-based physical activity programs may be a viable option to help introduce women to get active after treatment.
Trial registration ISRCTN, ISRCTN14747810. Registered on 18 October 2017—Retrospectively registered, 10.1186/ISRCTN14747810
Final Overall Survival of a Randomized Trial of Bevacizumab for Primary Treatment of Ovarian Cancer
Authors: Tewari Krishnansu S. , Burger Robert A. , Enserro Danielle , Norquist Barbara M. , Swisher Elizabeth M. , Brady Mark F. , Bookman Michael A. , Fleming Gini F. , Huang Helen , Homesley Howard D. , Fowler Jeffrey M. , Greer Benjamin E. , Boente Matthew , Liang Sharon X. , Ye Chenglin , Bais Carlos , Randall Leslie M. , Chan John K. , Ferriss J. Stuart , Coleman Robert L. , Aghajanian Carol , Herzog Thomas J. , DiSaia Philip J. , Copeland Larry J. , Mannel Robert S. , Birrer Michael J. , Monk Bradley J. 
Published: June 2019

PURPOSEWe report the final, protocol-specified analysis of overall survival (OS) in GOG-0218, a phase III, randomized trial of bevacizumab in women with newly diagnosed ovarian, fallopian tube, or primary peritoneal carcinoma.METHODSA total of 1,873 women with incompletely resected stage III to IV disease were randomly assigned 1:1:1 to six 21-day cycles of intravenous carboplatin (area under the concentration v time curve 6) and paclitaxel (175 mg/m2) versus chemotherapy plus concurrent bevacizumab (15 mg/kg, cycles 2 to 6) versus chemotherapy plus concurrent and maintenance bevacizumab (cycles 2 to 22). Inclusion criteria included a Gynecologic Oncology Group performance status of 0 to 2 and no history of clinically significant vascular events or evidence of intestinal obstruction. OS was analyzed in the intention-to-treat population. A total of 1,195 serum and/or tumor specimens were sequenced for BRCA1/2 and damaging mutations in homologous recombination repair (HRR) genes. Intratumoral microvessel density was studied using CD31 immunohistochemistry.RESULTSMedian follow-up was 102.9 months. Relative to control (n = 625), for patients receiving bevacizumab-concurrent (n = 625), the hazard ratio (HR) of death was 1.06 (95% CI, 0.94 to 1.20); for bevacizumab-concurrent plus maintenance (n = 623), the HR was 0.96 (95% CI, 0.85 to 1.09). Disease-specific survival was not improved in any arm. No survival advantage was observed after censoring patients who received bevacizumab at crossover or as second line. Median OS for stage IV bevacizumab-concurrent plus maintenance was 42.8 v 32.6 months for stage IV control (HR, 0.75; 95% CI, 0.59 to 0.95). Relative to wild type, the HR for death for BRCA1/2 mutated carcinomas was 0.62 (95% CI, 0.52 to 0.73), and for non- BRCA1/2 HRR, the HR was 0.65 (95% CI, 0.51 to 0.85). BRCA1/2, HRR, and CD31 were not predictive of bevacizumab activity.CONCLUSIONNo survival differences were observed for patients who received bevacizumab compared with chemotherapy alone. Testing for BRCA1/2 mutations and homologous recombination deficiency is essential.
Differences in quality of life and emotional health by diagnosis among women with early-stage gynecological cancers.
Authors: Vogel Rachel Isaksson , Jewett Patricia , Messelt Audrey , Lee Heewon , Everson-Rose Susan , Hatsukami Dorothy , Geller Melissa Ann , Teoh Deanna Gek Koon , Blaes Anne Hudson 
Published: June 2019

e23180 Background: Psychosocial outcomes have been described in women with gynecological cancers, but potential differences by diagnosis have received less attention. We sought to compare quality of life (QOL) and emotional health among early stage gynecological cancer survivors by disease location. Methods: We present baseline data from an ongoing cohort study of gynecological cancer patients treated at an academic cancer center. Measures include cancer-related QOL, emotional health and negative (post-traumatic stress disorder-PTSD) and positive (post-traumatic growth-PTG) reactions to cancer. Univariate and multivariate linear regression models (restricted to stage I or II; excluding vaginal/vulvar) explored differences in QOL and emotional health by diagnosis. Potential confounders considered for inclusion in the final models were age, stage, education, income, partner status, treatment status, and race. Results: 222 patients with early stage disease completed the survey: 56 (25.2%) ovarian, 122 (55.5) endometrial, 33 cervical (14.9%), and 11 (5%) vaginal/vulvar cancer. Cervical and vaginal/vulvar cancer patients reported greater cancer-related distress, anxiety and PTSD scores (Table). Endometrial cancer patients reported lowest PTG scores. Conclusions: Our analyses suggest early stage gynecological cancer patients face different psychosocial sequelae based on diagnosis, with worse outcomes generally being associated with younger age. Further research is needed to assess low PTG among endometrial cancer patients, since PTG is considered a potentially beneficial psychosocial outcome of cancer. [Table: see text]
Therapeutic Effects of Endogenous Incretin Hormones and Exogenous Incretin-Based Medications in Sepsis
Authors: Shah Faraaz Ali , Mahmud Hussain , Gallego-Martin Teresa , Jurczak Michael J , O’Donnell Christopher P , McVerry Bryan J 
Published: June 2019

Abstract

Background
Sepsis, a complex disorder characterized by a dysregulated immune response to an inciting infection, affects over one million Americans annually. Dysglycemia during sepsis hospitalization confers increased risk of organ dysfunction and death, and novel targets for the treatment of sepsis and maintenance of glucose homeostasis are needed. Incretin hormones are secreted by enteroendocrine cells in response to enteral nutrients and potentiate insulin release from pancreatic β cells in a glucose-dependent manner, thereby reducing the risk of insulin-induced hypoglycemia. Incretin hormones also reduce systemic inflammation in preclinical studies, but studies of incretins in the setting of sepsis are limited.

Methods
In this bench-to-bedside mini-review, we detail the evidence to support incretin hormones as a therapeutic target in patients with sepsis. We performed a PubMed search using the medical subject headings “incretins,” “glucagon-like peptide-1,” “gastric inhibitory peptide,” “inflammation,” and “sepsis.”

Results
Incretin-based therapies decrease immune cell activation, inhibit proinflammatory cytokine release, and reduce organ dysfunction and mortality in preclinical models of sepsis. Several small clinical trials in critically ill patients have suggested potential benefit in glycemic control using exogenous incretin infusions, but these studies had limited power and were performed in mixed populations. Further clinical studies examining incretins specifically in septic populations are needed.

Conclusions
Targeting the incretin hormone axis in sepsis may provide a means of not only promoting euglycemia in sepsis but also attenuating the proinflammatory response and improving clinical outcomes.
TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation
Authors: Miller Daniel S. J. , Schmierer Bernhard , Hill Caroline S. 
Published: June 2019

ABSTRACT
Growth factor-induced signal transduction pathways are tightly regulated at multiple points intracellularly, but how cells monitor levels of extracellular ligand and translate this information into appropriate downstream responses remains unclear. Understanding signalling dynamics is thus a key challenge in determining how cells respond to external cues. Here, we demonstrate that different TGF-β family ligands, namely activin A and BMP4, signal with distinct dynamics, which differ profoundly from those of TGF-β itself. The signalling dynamics are driven by differences in the localisation and internalisation of receptors for each ligand, which in turn determine the capability of cells to monitor levels of extracellular ligand. By using mathematical modelling, we demonstrate that the distinct receptor behaviours and signalling dynamics observed may be primarily driven by differences in ligand–receptor affinity. Furthermore, our results provide a clear rationale for the different mechanisms of pathway regulation found in vivo for each of these growth factors.
Measuring ‘Brand Love’ : Understanding the Attitude of Millennials towards Select Brands
Authors: Malik Garima , Guptha Abhinav 
Published: June 2019

The dynamic environment of markets has forced the market researchers to study customer orientation towards a product and his associations with the brand. Millennial are opinion leaders across all business domains in the society; this emphasizes the importance of this particular segment and their impact on brand equity. Indian business is very dynamic and is continuously being affected by the various changes due to the entry of new foreign players, high technological up gradations and changing consumer needs. Hence it has become very important for the marketers of the brands to make their brands more attractive to gain more loyalists. This study intends to propose the importance of the various factors that are responsible for creating ―brand love‖ in the mind of the consumer and thus make the business of the brand profitable for a long time. The validation of the scales for measurement has been proven through this study and top loved brands have been got from the respondents. Brand Love scales on the various brands in the Indian context have proven that love towards the brand generate a high amount of loyalty and have significant effects through a positive ‗word of mouth‘ comment.
flipkart.com’s Strategy on Amazon.com’s Entry into India :A Case Study
Authors: B Padmanabh 
Published: June 2019

The online retail industry in India is expected to grow to Rs. 7000 crores by 2015. Its size in 2013 is Rs. 2500 crores. By 2014 India is expected to become the 3rd largest nation of Internet users and this would provide huge potential to the online retail Industry1.Among the major cities in India, consumers in Mumbai topped the chart in doing online shopping followed by Ahmedabad and Delhi2. As per Google study conducted in 2012, 51 percent of the traffic for its Great online shopping festival (GOSF) was due to customers from cities other than the four metros. Referring to the growth in online sales, Nitin Bawankule, industry director, e-commerce, online classifieds and media/entertainment at Google India said, “Top motivators for shopping online include cash back guarantee, cash on delivery, fast delivery, substantial discounts compared to retail, and access to branded products”3. The E –commerce space in India has seen a lot of action and there are many online players like flipkart.com, Myntra.com, Fabmart, Indiaplaza and Indiatimesshopping. Amazon.com made an indirect entry through Junglee.com. The reason for this indirect entry is the result of government policy towards foreign direct investment. The Government of India announced in September 2012 the revised foreign direct investment policy in retail. As per this announcement foreign investments are blocked in e-commerce sector while allowing 51 percent FDI in multi-brand retail stores and 100 percent FDI in single brand retail. Amazon has been eyeing the Indian E commerce market which is estimated around $2 billion4.
Private Label Motivators and Product Category Association: An Empirical Study
Authors: Srivastava Dr. Ritu 
Published: June 2019

Abstract
Private labels are important contributors in a retail strategy, especially when the industry starts maturing and competition starts intensifying. While modern trade penetration in India is still low, the proportionate private label growth is much higher owing to a new generation of shoppers that is open to trying out new products and brands.It is thus important to understand the private label motivators in India and also to understand the role of product category in the private label decision. This particular study aims at these two objectives in the Indian context. The findings of the study indicate that product category does have an intervening role in the customer’s private label purchase decision. The implications need to be assessed and incorporated in the private label strategy of the retailers.
Are General Insurance Companies Efficient in their Performance? – A Comparison
Authors: Muthulakshmi P 
Published: June 2019

The insurance sector has witnessed significant changes in the last few years, specifically due to the effects of liberalisation, globalisation, and privatisation. It is imperative to compare and study the earnings and profitability of public sector non-life general insurance companies in India. The public sector non-life general insurance companies are competing with each other, and also with the private players in the same industry and thereby reducing the processing costs and facilitating the innovation of different types of policies across the geographic boundaries. In this paper, secondary data is used to analyse the earnings and profitability of non-life general insurance companies in India by using certain ratios which are available exclusively to evaluate the performance of insurance companies such as Claim Ratio, Expenses Ratio, Combined Ratio, Investment Income Ratio and Return on Equity Ratio.

, , , Ratio Analysis
Development Chitosan-based forward Osmosis Membranes for Emergency Drinking Water Supply
Authors: Saiful Saiful , Riana Ulfa , Marlina Marlina , Ramli Muliadi , Mahmud Nizar 
Published: June 2019

Development of forward osmosis (FO) membranes became one of the alternative methods for drinking water supply in an emergency. In this research, drinking water bags based on FO membrane have been developed using chitosan as the basic material of membrane. The chitosan membrane used for the manufacture of drinking water bags has a thickness of 0.043 mm, 30.3% porosity, tensile strength 28.83 kgf / mm2, swelling degree 43.5% and elongation of 7.16%. Drinking water bags are made with a combination of Polypropylene Plastic (PP) and aluminum foil with FO membrane inside. This drinking water bag can be applied for brackish water purification to be energy drinking water as one of the solutions for the drinking water supply in emergencies. FO process testing is done by using variation of sugar solution as the draw solution, that are glucose, fructose, sucrose and mixture. The concentration of applied draw solution is 1, 2 and 3M within 1 hour treatment. The highest water flux was obtained in 3M sucrose solution with a flux value of 5.25 L/m2hour. The results of drinking water quality parameters analysis in the form of pH, Total Dissolve Solid (TDS), salinity, conductivity, heavy metals and Escherichia coli (E. coli) contents showed that the FO water produc meets drinking water quality standards based on Indonesian government regulation of drinking water quality. FO-membrane-based drinking water bags are potentially used as an alternative solution for the energy drinking water supply in an emergency.
Öğrenme Kuramlarının Çevrimiçi Öğretim Ortamlarında ve Materyallerinde Uygulanması: Bir Ölçütler Takımı Geliştirme Çalışması
Authors: ÖZER ŞANAL Seda , AKÇAY Arif , ÇİÇEK TUTULMAZ Meral , ERDEM Mukaddes 
Published: June 2019

Bu çalışma, çevrimiçi
öğretim ortamlarının ve materyallerinin öğrenme kuramları perspektifinden
incelenmesini ya da oluşturulmasını olanaklı kılacak, üzerinde uzlaşılmış bir
ölçütler takımı oluşturmak üzere gerçekleştirilmiştir. Bir öğretim tasarım
sürecinin, planlanmasından uygulanıp geliştirilmesine kadar geçen tüm
aşamalarında öğrenme kuramlarının rehberliğine gereksinim olduğu anlayışıyla
gerçekleştirilen çalışmada; öncelikle davranışçı, bilişsel ve yapılandırmacı
öğrenme kuramlarının öğrenmeye ilişkin açıklamaları incelenmiştir. Daha sonra,
bu açıklamaların öğretim ortam ya da materyallerinde nasıl karşılık bulacağı,
öğretimsel uygulamalar türünden belirlenmeye çalışılmıştır. Uzman görüşleri
doğrultusunda gözden geçirilen bu ilk ifadeler, 5’li likert tipinde bir ölçek
formunda düzenlenmiştir. Ölçek yeniden uzman görüşüne sunulmuş ve alınan
görüşler doğrultusunda düzenlenmiştir. 70 maddeden oluşan yeni form
kullanılarak; EBA(Eğitim Bilişim Ağı)’dan herkese açık 6 farklı öğretim
materyali incelenmiştir. 3 değerlendirici tarafından gerçekleştirilen
inceleme 4 araştırmacının da katılımıyla gözden geçirilmiş ve 10 madde ölçekten
çıkarılmıştır. 60 maddelik ölçek üzerinden değerlendiriciler arası uyum
düzeyleri hesaplanmıştır. Kabul edilebilir uyum düzeyleri belirlenen 60
maddelik ölçek, 26 kişilik bir uzman grubun görüşüne sunularak kapsam geçerlik
indeksleri hesaplanmıştır. Ölçeğin alt boyutlarına göre kapsam geçerlik
indeksleri; kurama uygunluk açısından davranışçılıkta 0.78 (p&lt;.05), bilişsel
anlayışta 0.87 (p&lt;.05) ve yapılandırmacılıkta 0.85 (p&lt;.05)’tir. Bu son
inceleme ile 60 maddelik bir ölçütler takımına erişilmiştir.
The role of superlinear damping in the construction of solutions to drift-diffusion problems with initial data in L1
Authors: Winkler Michael 
Published: June 2019

AbstractIn boundedn-dimensional domainsΩ, the Neumann problem for the parabolic equation$$\begin{array}{} \displaystyle u_t = \nabla \cdot \Big( A(x,t)\cdot\nabla u\Big) + \nabla \cdot \Big(b(x,t)u\Big) - f(x,t,u)+g(x,t) \end{array}$$(*)is considered for sufficiently regular matrix-valuedA, vector-valuedband real valuedg, and withfrepresenting superlinear absorption in generalizing the prototypical choice given byf(⋅, ⋅,s) =sαwithα> 1. Problems of this form arise in a natural manner as sub-problems in several applications such as cross-diffusion systems either of Keller-Segel or of Shigesada-Kawasaki-Teramoto type in mathematical biology, and accordingly a natural space for initial data appears to beL1(Ω).The main objective thus consists in examining how far solutions can be constructed for initial data merely assumed to be integrable, with major challenges potentially resulting from the interplay between nonlinear degradation on the one hand, and the possibly destabilizing drift-type action on the other in such contexts. Especially, the applicability of well-established methods such as techniques relying on entropy-like structures available in some particular cases, for instance, seems quite limited in the present setting, as these typically rely on higher initial regularity properties.The first of the main results shows that in the general framework of (*), nevertheless certain global very weak solutions can be constructed through a limit process involving smooth solutions to approximate variants thereof, provided that the ingredients of the latter satisfy appropriate assumptions with regard to their stabilization behavior.The second and seemingly most substantial part of the paper develops a method by which it can be shown, under suitably stregthened hypotheses on the integrability ofband the degradation parameterα, that the solutions obtained above in fact form genuine weak solutions in a naturally defined sense. This is achieved by properly exploiting a weak integral inequality, as satisfied by the very weak solution at hand, through a testing procedure that appears to be novel and of potentially independent interest.To underline the strength of this approach, both these general results are thereafter applied to two specific cross-diffusion systems. Inter alia, this leads to a statement on global solvability in a logistic Keller-Segel system under the assumptionα>$\begin{array}{} \frac{2n+4}{n+4} \end{array}$on the respective degradation rate which seems substantially milder than any previously found condition in the literature. Apart from that, for a Shigesada-Kawasaki-Teramoto system some apparently first results on global solvability forL1initial data are derived.
Chiral and Achiral Enantiomeric Separation of (±)-Alprenolol
Authors: Guerrero M.M. López , Díaz A. Navas , Sánchez F. García , Corrall H. 
Published: June 2019

AbstractThe chiral separation of enantiomers is crucial for pharmacovigilance within drug discovery. Although a large number of prescribed medications are marketed as pure enantiomers, this is not always the case and many are in fact racemic mixtures. Drug scandals, such as that of Thalidomide in 1961, provide a clear example of the social and economic repercussions that can be caused by negligence of these chiral compounds. Two high performance liquid chromatography (HPLC) methods are presented to determine, separate and quantitate a commonly prescribed chiral beta blocker, (-)-Alprenolol. The first method utilises a chiral column to physically separate the two enantiomers of Alprenolol in 25 minutes, before quantitating with two detectors. Fluorimetry gave the better limit of detection of 0.16-0.41ng and a correlation coefficient of 0.999. The second method used an achiral column coupled with polarimetry to quantitate (-)-Alprenolol without the need for physical separation in 10 minutes. The limit of detection achieved was 27-37μg and demonstrated a correlation coefficient of -0.999.