bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the integration of thermal imaging technology with the data mining algorithms for precise prediction of honey and beeswax yield
Authors: Kibar Mustafa , Altay Yasin , Aytekin İbrahim 
Published: December 2024

AbstractSustainability in beekeeping depends on identifying the factors affecting honey and beeswax yields (HY and BWY) ‐ key products ‐ and accurately predicting these yields. Therefore, this study aimed to predict HY and BWY using a classification and regression tree (CART), eXtreme Gradient Boosting (XGBoost) and Random Forest (RF) algorithms, and thermal image processing in Apis mellifera. In this study, 13 colonies of 6 different breeds raised in 10‐frame Langstroth hives were used. The effects of independent variables were predicted using data mining algorithms and 15 performance metrics for the effectiveness of the algorithms. Colony power (CP), thermal temperatures (Tmin, Tmax, and Tmean), breed, a*, b*, red, green, saturation, and brightness impacted HY and BWY in different algorithms, but not birth year of queen, L, hue and blue. As a result, XGBoost, CART, and RF demonstrated high predictive performance, respectively. Due to their higher predictive performance, XGBoost and CART algorithms could predict HY and BWY using CP, thermal temperatures, and image values. These techniques could be useful for producers to monitor production quickly and non‐invasively without threatening colony welfare.
Core medication use in general practice prescriptions: A pilot study evaluating the Drug Utilization 90% Index in Irish general practice
Authors: McCarthy Caroline , Moynagh Patrick , Fahey Tom , Boland Fiona , Moriarty Frank 
Published: December 2024

AimsThe Drug Utilization 90% Index (DU90%), the number of medicines making up 90% of a doctor's prescribing, is a simple tool that can be used to describe core prescribing patterns. This research aimed to pilot the application of the DU90% in the Irish context, to investigate the relationship between the DU90% and prescriber and practice characteristics and prescribing quality.MethodsRetrospective observational study using anonymous prescription data from a sample of Irish general practitioners (GPs). Participating GPs provided demographic details and extracted prescription data for 2018–2022 using their existing software systems. The DU90% was calculated annually at both the practice and prescriber level. Prescribing quality indicators included antibiotic, benzodiazepine prescribing rates and high‐risk nonsteroidal anti‐inflammatory drug prescribing. The association of the DU90% with prescriber and practice characteristics and prescribing quality indicators was explored with multilevel modelling.ResultsThirty‐eight prescribers from 22 different practices were included. The mean DU90% for prescribers was 141.5 (standard deviation 12.9) and for practices was 145.62 (standard deviation 11.87). Practices in receipt of the rural deprivation grant had a significantly lower DU90% (incidence rate ratio 0.94, 95% confidence interval 0.88–0.98). There was no evidence of an association between prescriber‐level characteristics and the DU90% (sex, years qualified, number of sessions worked). There was a small positive relationship between the prescriber DU90% and total prescriptions, antibiotic and benzodiazepine prescribing rates, and higher rates of high‐risk nonsteroidal anti‐inflammatory drug prescriptions.ConclusionApplying the DU90% to Irish general practice prescriptions is feasible, revealing that GPs typically use 140 medicines in the bulk of their prescribing.
The Use of the Facial Sinus Wall as Bone Shell Onlay Graft for Maxillary Posterior Ridge Reconstruction: A Retrospective Case Series
Authors: Krennmair Stefan , Weinländer Michael , Malek Michael , Forstner Thomas , Stimmelmayr Michael , Krennmair Gerald 
Published: December 2024

ABSTRACTPurposeTo evaluate the performance and clinical outcome of vertical and horizontal bone augmentation (VHBA) in posterior maxillary regions combining lateral window sinus floor elevation (LWSFE) with a horizontal bone shell technique applying the maxillary facial sinus wall as a bone plate.Materials and MethodsIn 18 patients, LWSFE was combined with a horizontal bone shield augmentation procedure utilizing the maxillary facial sinus bone wall as a lateral bone plate. Both the sinus cavity and the lateral bone box created were grafted with a mixture of autogenous bone/venous blood and bovine bone mineral. The primary aim was to assess the performance of combined techniques enabling subsequent implant placement. Using radiographic measurements (preoperative, after VHBA, at implant placement, and at follow‐up), bone gain/reduction of augmented horizontal ridge width (HRW) and vertical bone height (VBH) were evaluated. Additionally, clinical outcome assessing implant survival/success rate, marginal bone loss (MBL), and implant health (mucositis/peri‐implantitis) was evaluated.ResultsFor the combined VHBA techniques, HRW and VBH increased significantly (p < 0.001) from preoperative 3.5 ± 1.4 mm/3.6 ± 2.1 mm to 9.7 ± 1.9 mm/18.0 ± 1.6 mm post‐augmentation. However, HRW and VBH dimensions decreased up to 8.9 ± 1.8 mm/17.1 ± 1.4 mm at implant placement and 8.6 ± 1.7 mm/16.7 ± 1.3 mm at follow‐up evaluation (3.8 ± 1.8 years; p < 0.001, respectively). Augmented bone reduction was significantly higher (−7.7%) between the augmentation procedure and implant placement than in the post‐implant‐placement period (−2.5%). All implants survived (100%) representing peri‐implant MBL of −0.9 ± 0.7 mm, pocket depth of 3.4 + 1.8 mm, and prevalences of 5%/0% for peri‐implant mucositis/peri‐implantitis.ConclusionThe combination of horizontal bone augmentation using local bone shield transfer from the maxillary facial sinus wall with LWSFE enables sufficient reconstruction of maxillary posterior ridge.
Mef2c Exacerbates Neuron Necroptosis via Modulating Alternative Splicing of Cflar in Ischemic Stroke With Hyperlipidemia
Authors: Li Ruqi , Huang Tianchen , Zhou Jianpo , Liu Xiansheng , Li Gan , Zhang Yueman , Guo Yunlu , Li Fengshi , Li Yan , Liesz Arthur , Li Peiying , Wang Zhenghong , Wan Jieqing 
Published: December 2024

ABSTRACTAimHyperlipidemia is a common comorbidity of stroke patients, elucidating the mechanism that underlies the exacerbated ischemic brain injury after stroke with hyperlipidemia is emerging as a significant clinical problem due to the growing proportion of hyperlipidemic stroke patients.MethodsMice were fed a high‐fat diet for 12 weeks to induce hyperlipidemia. Transient middle cerebral artery occlusion was induced as a mouse model of ischemic stroke. Emx1Cre mice were crossed with Mef2cfl/fl mice to specifically deplete Mef2c in neurons.ResultsWe reported that hyperlipidemia significantly aggravated neuronal necroptosis and exacerbated long‐term neurological deficits following ischemic stroke in mice. Mechanistically, Cflar, an upstream necroptotic regulator, was alternatively spliced into pro‐necroptotic isoform (CflarR) in ischemic neurons of hyperlipidemic mice. Neuronal Mef2c was a transcription factor modulating Cflar splicing and upregulated by hyperlipidemia following stroke. Neuronal specific Mef2c depletion reduced cerebral level of CflarR and cFLIPR (translated by CflarR), while mitigated neuron necroptosis and neurological deficits following stroke in hyperlipidemic mice.ConclusionsOur study highlights the pathogenic role of CflarR splicing mediated by neuronal Mef2c, which aggravates neuron necroptosis following stroke with comorbid hyperlipidemia and proposes CflarR splicing as a potential therapeutic target for hyperlipidemic stroke patients.
Vergleichende Studie zur sexuellen Dysfunktion bei Alopecia areata: Prävalenz und assoziierte Faktoren
Authors: Muñoz‐Barba Daniel , Díaz‐Calvillo Pablo , de Francisco Sofía Haselgruber , Martínez‐López Antonio , Sánchez‐Díaz Manuel , Arias‐Santiago Salvador 
Published: December 2024

ZusammenfassungHintergrund und ZielsetzungAlopecia areata (AA) beeinträchtigt die Lebensqualität. Es gibt jedoch keine Evidenz hinsichtlich der Auswirkungen dieser Erkrankung in Bezug auf die sexuelle Dysfunktion (SD). Ziel der vorliegenden Studie war es, die Prävalenz der SD und mögliche damit assoziierte Faktoren in einer Kohorte von Patienten mit Alopecia areata zu untersuchen.Patienten und MethodenEs wurde eine Querschnittsstudie an einer Kohorte von AA‐Patienten durchgeführt, die mit gesunden Kontrollpersonen verglichen wurde. Die sexuelle Funktion wurde anhand einer numerischen Skala und geschlechtsspezifischer Fragebögen bewertet.ErgebnisseInsgesamt wurden 60 Patienten mit AA und 60 gesunde Kontrollpersonen eingeschlossen. Die Prävalenz von SD war bei den Patientinnen mit AA höher als bei den gesunden Kontrollen und bei Männern mit AA (p < 0,05). Bei den Frauen war die SD mit jüngerem Alter, kürzerer Krankheitsdauer sowie höheren Raten von Angstzuständen und Depressionen assoziiert (p < 0,05). Die männliche SD wurde mit höherem Alter und größerem Schweregrad der AA in Verbindung gebracht (p < 0,05).SchlussfolgerungenDie Raten von SD scheinen bei Frauen mit AA höher zu sein als bei gesunden Kontrollpersonen und Männern mit AA. Auch die Faktoren, die mit SD assoziiert sind, unterscheiden sich zwischen Frauen und Männern, wobei Stimmungsstörungen bei Frauen von größerer Relevanz sind, während die Schwere der Erkrankung bei Männern eine Schlüsselrolle zu spielen scheint.
Versorgung von Patienten mit atopischer Dermatitis durch Hausärzte – eine bundesweite Erhebung in Deutschland
Authors: Langenbruch Anna , Andrees Valerie , Scherer Martin , Augustin Matthias 
Published: December 2024

ZusammenfassungHintergrund und ZielsetzungEpidemiologische Studien zur dermatologischen Versorgung von Patienten mit atopischer Dermatitis (AD) in Deutschland zeigen innerhalb von 10 Jahren keine Verbesserung. Neben Dermatologen sind vor allem auch Hausärzte (GP) an der Behandlung von Patienten mit AD beteiligt. In dieser Studie wurde die Versorgungssituation erwachsener Patienten, die wegen AD in hausärztlicher Behandlung sind, analysiert.Patienten und MethodikDie Querschnittserhebung „PsoADA‐AD“ wurde von 2019 bis 2021 bundesweit in hausärztlichen Praxen durchgeführt. Die Ergebnisse wurden mit Daten aus der dermatologischen Versorgung (AtopicHealth2, 2017–2019) verglichen.ErgebnisseVon den 150 Patienten (mittleres Alter: 40 Jahre, 62,2% weiblich) wurden 39,2% zusätzlich von Dermatologen (GP+D) behandelt. Unter diesen hatten 20,7% eine schwere AD, während dies unter den nur hausärztlich behandelten Patienten (GP only) auf 5,7% zutraf (p < 0,01, AtopicHealth2: 27,6%). Erhebliche Einschränkungen in ihrer Lebensqualität berichteten 31,0% (GP+D) vs. 3,4% (GP only) (p < 0,001, AtopicHealth2: 31,6%). Die meisten Patienten erhielten topische Medikamente, hauptsächlich Glukokortikosteroide. Calcineurininhibitoren wurden aktuell von 2,7% (PsoADA‐AD gesamt) verwendet. Bereits an einer Neurodermitisschulung teilgenommen zu haben, gaben 5,7% (PsoADA‐AD gesamt) an.SchlussfolgerungenEin erheblicher Teil der Patienten mit AD in der hausärztlichen Versorgung zeigt eine schlechte Erkrankungskontrolle, wie es auch in der dermatologischen Versorgung beobachtet wurde. Ein Grund könnte der fehlende Einsatz moderner Systemtherapeutika sein.
S2k‐Leitlinie Basalzellkarzinom der Haut (Aktualisierung 2023)
Authors: Lang Berenice M. , Balermpas Panagiotis , Bauer Andrea , Blum Andreas , Dirschka Thomas , Follmann Markus , Frank Jorge , Frerich Bernhard , Fritz Klaus , Hauschild Axel , Heindl Ludwig M. , Howaldt Hans‐Peter , Ihrler Stephan , Kakkassery Vinodh , Klumpp Bernhard , Krause‐Bergmann Albrecht , Löser Christoph , Meissner Markus , Sachse Michael M. , Schlaak Max , Schön Michael P. , Tischendorf Lutz , Tronnier Michael , Vordermark Dirk , Welzel Julia , Weichenthal Michael , Wiegand Susanne , Kaufmann Roland , Grabbe Stephan 
Published: December 2024

ZusammenfassungDas Basalzellkarzinom ist der häufigste maligne Tumor der hellhäutigen Bevölkerung mit weiterhin steigender Inzidenz. Ein Update der S2k‐Leitlinie unter Beteiligung aller mit dem Krankheitsbild vertrauten Fachgesellschaften sowie vorangegangener Literaturrecherche ist für die Qualität der Versorgung der betroffenen Patienten von hoher Bedeutung. Neben der Epidemiologie werden Diagnostik und Histologie diskutiert. Die Therapie wird nach einer Risikostratifizierung in topische, systemische und Strahlentherapie gegliedert. Die chirurgische Entfernung bleibt weiterhin in den meisten Fällen die Therapie der ersten Wahl. Durch die Zulassung von Anti‐PD1‐Inhiboren für lokal fortgeschrittene und metastasierte Tumoren ergab sich in der Zweitlinien‐Therapie eine neue Option (nach Hedgehog‐Inhibitoren).
Visual information processing of 2D, virtual 3D and real‐world objects marked by theta band responses: Visuospatial processing and cognitive load as a function of modality
Authors: Kisker Joanna , Johnsdorf Marike , Sagehorn Merle , Hofmann Thomas , Gruber Thomas , Schöne Benjamin 
Published: December 2024

AbstractWhile pictures share global similarities with the real‐world objects they depict, the latter have unique characteristics going beyond 2D representations. Due to its three‐dimensional presentation mode, Virtual Reality (VR) is increasingly used to further approach real‐world visual processing, yet it remains unresolved to what extent VR yields process comparable to real‐world processes. Consequently, our study examined visuospatial processing by a triangular comparison of 2D objects, virtual 3D objects and real 3D objects. The theta band response (TBR) was analysed as an electrophysiological correlate of visual processing, allowing for the differentiation of predominantly stimulus‐driven processes mirrored in the evoked response and internal, complex processing reflected in the induced response. Our results indicate that the differences between conditions driven by sensory features go beyond a binary division into 2D and 3D materials but are based on further sensory features: The evoked posterior TBR differentiated between all conditions but revealed fewer differences between processing of real‐world and VR objects. Moreover, the induced midfrontal TBR indicated higher cognitive load for 2D objects compared to VR and real‐world objects, while no difference between both latter conditions was revealed. In conclusion, our results demonstrate that the transferability of 2D‐ and VR‐based findings to real‐world processes depends to some degree on whether predominantly sensory stimulus features or higher cognitive processes are examined. Yet although VR and real‐world processes are not to be equated based on our results, their comparison yielded fewer significant differences relative to the PC condition, advising the use of VR to examine visuospatial processing.
Is it time to acknowledge intramucosal colorectal carcinoma?
Authors: Vink‐Börger Elisa , Knijn Nikki , de Bruine Adriaan , Stavast Jeroen , van der Post Rachel Sophia , Nagtegaal Iris 
Published: December 2024

AimThe term ‘intramucosal carcinoma’ in the colorectum is controversial when used as a synonym for high‐grade dysplasia. However, setting clear definitions for this diagnosis (i.e. unequivocal infiltrative growth in the lamina propria, which might be most easily recognized in cases with overt poor differentiation or formation of signet ring cells or tumour budding) allow us to investigate its relevance.Methods and ResultsWe reviewed cases from our archive (1990–2024) and selected 14 true intramucosal carcinomas using our strict histological criteria, excluding high‐grade dysplasia and invasive carcinomas. These occur primarily in conventional adenomas and are frequently associated with microsatellite instability (50%). Our study shows a low estimated incidence of intramucosal carcinoma (0.01%) in population screening and highlights the low lymph node risk and the good outcome of patients with intramucosal carcinoma.ConclusionThe rare diagnosis of intramucosal colorectal carcinoma aids in identifying patients at increased colorectal cancer risk, notably those with hereditary syndromes. Standardizing this diagnosis is critical to prevent overdiagnosis and unnecessary treatment.
Exploring the Feasibility and Acceptance of Delivering Oral Health Interventions in a Primary Care Diabetes Context in North East England: A Qualitative Two‐Case Study
Authors: Bissett Susan M. , Preshaw Philip M. , Presseau Justin , Rapley Tim 
Published: December 2024

ABSTRACTThe evidence base supporting a bidirectional relationship between diabetes and periodontitis is well‐established and published guidance recommends inter‐professional management. This two‐case study describes the development and implementation of an evidence‐based oral health intervention delivered in diabetes review consultations in NHS primary medical care in Northeast England.AimThe intervention aim was to inform people with diabetes about the links between diabetes and periodontitis, and signpost them to a dental professional for assessment.MethodsThe study utilised focus groups in the design phase and a mixture of focus groups and interviews in the evaluation phase.ResultsTwo research active primary care medical practices were recruited. The interventions were informed by their diabetes management protocols to reduce disruption. The interventions were piloted for 2 months, and staff and patient perceptions were evaluated. The findings from this study suggested that the oral health interventions were feasible and acceptable particularly for nurses and health care assistants when delivering diabetes education, but they caused disruption to the GPs review, which included complex medication reviews and referrals. The patients (n = 2) found the intervention to be acceptable and appropriate in the context of their diabetes review.ConclusionMedical staff and patient evaluation data appear to suggest acceptance of the introduction of an oral health intervention into the diabetes review, but it is difficult to assess the impact of the intervention. Further research, such as a realist review, is needed to evaluate the outcomes and utility of an oral health intervention in the context of the medical management of diabetes in primary care.
Effect of ICG fluorescence‐assisted new nerve‐sparing of robot‐assisted radical prostatectomy on lower urinary tract symptoms
Authors: Gunge Naotaka , Fukuhara Yuichiro , Matsuoka Wataru , Fumihiro Yamazaki , Tachibana Masahiro , Nakagawa Chizuru , Tominaga Kosuke , Aoyagi Chikao , Miyazaki Takeshi , Okabe Yu , Tsubouchi Kazuna , Matsuzaki Hiroshi , Nakamura Nobuyuki , Haga Nobuhiro 
Published: December 2024

ObjectivesThe aim of the present study was to determine the efficacy and safety of our newly developed ICG‐assisted nerve‐sparing (NS) robot‐assisted radical prostatectomy (RARP) through subjective and objective data.MethodsThis study included 43 NS RARP patients, divided into ICG (23 patients) and non‐ICG (20 patients) groups. Immunohistochemical staining with nNOS antibodies was conducted on specimens of resected prostate from the base, middle, and apex to count nNOS‐positive cells. Fewer nNOS‐positive cells suggested higher quality for the NS procedure. Postoperative erectile function, urinary incontinence, lower urinary tract symptoms (LUTS) as evaluated by the International Prostate Symptom Score (IPSS), and lower urinary tract function were compared between groups, operative time, and adverse events.ResultsOnly the number of n‐NOS‐positive cells at the base differed significantly between the ICG group (15.0 ± 6.9) and the non‐ICG group (26.9 ± 21.4, p = 0.02). Regarding LUTS, in the ICG group, significant improvement was only seen in postoperative IPSS scores (13.6 ± 4.9 to 8.7 ± 5.0, p = 0.02). No significant differences in the postoperative erectile function, urinary incontinence, and lower urinary tract function were seen between groups. In addition, significant differences in operative time and rate of adverse events were not observed between groups.ConclusionOur innovative approach enhances the visualization of prostatic boundaries, suggesting potential for reliable and straightforward NS procedures, with a significant improvement in LUTS, without evidence of prolonged operative time or an increased frequency of adverse events.
Triplet therapy for metastatic castration‐sensitive prostate cancer: Rationale and clinical evidence
Authors: Suzuki Hiroyoshi , Akamatsu Shusuke , Shiota Masaki , Kakiuchi Haruka , Kimura Takahiro 
Published: December 2024

AbstractProstate cancer (PC) growth is hormone‐dependent and it frequently develops distant metastases as disease progresses. Patients with metastatic castration‐sensitive prostate cancer (mCSPC) initially respond to androgen deprivation therapy (ADT) but eventually become refractory and develop metastatic castration‐resistant prostate cancer (mCRPC). Castration‐resistance is associated with high lethality and metastases confer poor prognosis, therefore unmet needs in treatment for mCSPC remain high. So far, improvements in survival in mCSPC have been achieved by doublet combination therapy such as docetaxel or an androgen‐receptor signaling inhibitor (ARSI) in addition to ADT. Further, recent phase 3 trials have shown that triplet therapy—a combination of ARSI, docetaxel, and ADT improves prognosis compared with docetaxel plus ADT in mCSPC. PC tumors manifest intra‐ and inter‐tumoral heterogeneity at both the genetic and phenotypic level. As heterogeneity increases during sequential treatment and disease progression, it is reasonable to initiate combination therapy using drugs with different mechanisms of action early in the course of disease, such as mCSPC. Previous research about tumor heterogeneity and drug resistant mechanism support this rationale, as well as preclinical studies and real‐world data provide the scientific evidence of benefit by combining ARSI and docetaxel. Here, we review the rationale and clinical evidence for triplet therapy in patients with mCSPC.
Decision‐making and coordination of a three‐tier fresh agricultural product supply chain considering dynamic freshness‐keeping effort
Authors: Wang Xuefeng , Xiong Meifei , Yang Fang , Shi Wenqiang 
Published: December 2024

AbstractThe freshness‐keeping of agricultural products is an essential issue that affects business development, food safety, and human health. Due to the structural characteristics of the supply chain, keeping the freshness of agricultural products involves different entities and multiple links, which is a long‐term strategic issue requiring significant investment. Given the perishability of agricultural products, the aging of preservation facilities, or the decline of technology, it is critical to consider the multitier freshness‐keeping strategy from a dynamic perspective. Therefore, this paper studies dynamic freshness‐keeping and coordination of a multitier agricultural product supply chain. We first construct a differential equation considering the three‐tier freshness‐keeping efforts. Then, we compare the optimal freshness‐keeping efforts, retail price, and system profit between the decentralized and centralized decision‐making models. Finally, two contracts based on cost‐sharing and secondary transfer payment are designed to coordinate the decentralized decision‐making model. Results show that (i) as the decision sequence moves backward, freshness‐keeping effort decreases at each tier for the same freshness‐keeping efficiency; (ii) adopting the centralized decision‐making model offers several advantages, including well‐balanced freshness‐keeping efforts across multiple tiers, a lower retail price, and higher system profit; and (iii) under a specified payment range, the “freshness‐keeping cost‐sharing‐two‐part fee” contract motivates entities to increase freshness‐keeping efforts and realizes individual and system‐wide profit improvements.