bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors associated with invasive orthopaedic interventions in males with haemophilia enrolled in the Universal Data Collection program from 2000 to 2010
Authors: Tobase P. , Lane H. , Siddiqi A.‐E.‐A , Soucie J. M. , Ingram‐Rich R. , Ward S. , Gill J. C. ,   the Hemophilia Treatment Center Network (HTCN) Study Investigators
Published: June 2018

BackgroundInvasive orthopaedic interventions (IOI) are often used to control recurrent haemarthrosis, pain and loss of joint function, in males with haemophilia (Factor VIII and Factor IX deficiency).AimIdentify risk factors associated with IOIs in males with haemophilia enrolled in the Universal Data Collection (UDC) surveillance program from 2000 until 2010.MethodsData were collected on IOIs performed on patients receiving care in 130 haemophilia treatment centers in the United States annually by health care providers using standardized forms. IOIs included in this study are as follows: 1) synovectomy and 2) arthrodesis or arthroplasty (A/A). Information about potential risk factors was obtained from the preceding UDC visit if available, or from the same visit if not. Patients with no reported IOI at any of their UDC visits were the reference group for the analysis. Multivariate analyses were conducted to identify independent risk factors for synovectomies and arthrodesis/arthroplasty.ResultsRisk factors significantly associated with the two IOI categories were age, student status, haemophilia severity, number of joint bleeds within the last 6 months, HIV or hepatitis C (HCV) status. Multivariate analyses showed patients on continuous prophylaxis were 50% less likely to have had a synovectomy and were 40% less likely to have an A/A.ConclusionsThis study shows modifiable risk factors, including management of bleeding episodes with a continuous prophylactic treatment schedule are associated with a decreased likelihood of IOIs in males with haemophilia.
Medieval English peasant women and their historians: A historiography with a future?
Authors: Wright Sharon Hubbs 
Published: June 2018

AbstractScholarship concerning medieval peasant women grew out of economic, Marxist, legal, and social history and, since the late 1970s, has been taken up mainly by medieval scholars using feminist methodologies. This research has been conducted by a handful of scholars most actively working before 2000. A large portion of this research has been focused on recovering information about peasant women's daily lives, their occupations, and their remuneration for work. From this body of research, scholars have attempted to understand and demonstrate the social and cultural conditions which affected peasant women's status and their agency. While most agree that peasant women's lives were profoundly affected by gendered ideas, there has been debate about the degree to which patriarchal institutions and beliefs have limited women's lives. This article focuses on scholarship concerning peasant women situated in their own social milieu, rather than their representation in art and literature. It argues that there remain many opportunities for further research, especially in the form of team‐based research, which is becoming more common in digital humanities.
Rheological properties of gluten and gluten‐starch model doughs containing wheat bran dietary fibre
Authors: Han Wen , Ma Sen , Li Li , Zheng Xueling , Wang Xiaoxi 
Published: June 2018

SummaryThe effect of wheat bran dietary fibre (WBDF) on the texture and extensional properties of gluten (G) as well as gluten‐starch (G+S) doughs were investigated. Texture analysis revealed an increasing hardness of WBDF‐enriched doughs, ascribed to the gradual formation of intermolecular hydrogen bonds and weakened aggregation behaviour of gluten proteins. Extension results showed that G and G+S systems exhibited growing extension resistance thanks to the strengthened strain‐hardening capacity induced by WBDF. On the other hand, the WBDF accelerated the rupture of the gluten network and led to a downtrend of dough extensibility by increasing the friction with gluten branches and impairing the uniformity of the network structure. The findings indicate the possible impairment of the dough texture properties upon the addition of WBDF. Accordingly, for bran‐enriched flour products, the pretreatment with bran‐like particles leading to size reduction, softening or solubility improvement may be advantageous.
Participation in decision‐making about medication: A qualitative analysis of medication adherence
Authors: Inder Maree , Lacey Cameron , Crowe Marie 
Published: June 2018

AbstractRates of relapse in BD are high with medication nonadherence identified as an important contributor to relapse. Psychopharmacology remains a key component to the treatment of BD; therefore, increased understanding of medication use and ways to promote greater adherence is essential. The aim of the study was to identify how participants with BD experience taking prescribed medication. Participants had BD I or BD II, were users of specialist mental health services, aged 18–64 years, euthymic, mildly hypomanic or depressed, and on any combination of medication. Exclusion criteria were minimal. A semistructured interview was completed exploring patients’ views of BD and factors influencing adherence based on the Subjective Experience of Medication Interview. An inductive thematic analysis was used to identify themes. The study participants (n = 36) had predominantly bipolar I (78%) and were female (69%), and of New Zealand European ethnicity (67%) with 14% Maori. The mean age was 41 years (SD: 12.0). Findings from the thematic analysis generated three themes: Learning about the clinical meaning of having BD, Understanding how to use medication, and Understanding what works for me. The qualitative nature of our study limits the generalizability of our findings to a broader population of individuals with BD. The participants developed confidence in being in charge of their BD through a process of learning about BD and medication and understanding what this meant for them. The findings support greater emphasis on collaborative approaches that recognize the expertise of the individual with BD and the clinician.
Phase equilibria, structure, oxygen nonstoichiometry, and thermal expansion of oxides in the 1/2Y2O3–SrO–1/2Fe2O3 system
Authors: Urusova Anastasia S. , Rudik Victoria V. , Mychinko Mikhail Yu. , Cherepanov Vladimir A. 
Published: June 2018

AbstractPhase equilibria in the 1/2Y2O3–SrO–1/2Fe2O3 system were systematically studied at 1373 K in air. The homogeneity ranges and crystal structure of the solid solutions Sr1−xYxFeO3−δ with 0.875 ≤ x ≤ 1 (sp. gr. Pnma) and 0.05 ≤ x ≤ 0.25 (sp. gr. Pm3 m) and Sr3−zYzFe2O7−δ with 0 ≤ z ≤ 0.25 (sp. gr. I4/mmm) were determined by X‐ray diffraction analysis of quenched samples. The structural parameters of the single‐phase oxides were refined by the Rietveld profile method. The isothermal‐isobaric phase diagram for the 1/2Y2O3–SrO–1/2Fe2O3 system at 1373 K in air is presented. The changes of oxygen content in the solid solutions Sr1−xYxFeO3−δ (0.05 ≤ x ≤ 0.25) and Sr3−zYzFe2O7−δ with 0 ≤ z ≤ 0.25 vs temperature in air were determined by the thermogravimetric analysis. Oxygen content was also calculated from the iodometric titration results. The gradual substitution of strontium by yttrium in Sr1−xYxFeO3−δ (0.05 ≤ x ≤ 0.25) leads to a decrease in the oxygen content and the mean oxidation state of iron. The average thermal expansion coefficients for Sr1−xYxFeO3−δ (0.875 ≤ x ≤ 1 and 0.05 ≤ x ≤ 0.25) and Sr3−zYzFe2O7−δ (0 ≤ z ≤ 0.25) were calculated within the temperature range 298‐1373 K in air.
Model for SiC fiber strength after oxidation in dry and wet air
Authors: Hay Randall S. , Mogilevsky Pavel 
Published: June 2018

AbstractThe strengths of oxidized SiC fibers were modeled from the effects of SiO2 scale residual stress on fracture. Surface tractions from scale residual stress were determined for SiC surface flaws. The residual stress was the sum of the growth stress from oxidation volume expansion, thermal stress from SiO2‐SiC thermal expansion mismatch, and stress from phase transformations in crystallized scale. The partial relaxation of tensile residual stress from scale cracking was also calculated. Scale thicknesses were determined using Deal‐Grove oxidation kinetics for glass and crystalline scales. Kolmogorov‐Johnson‐Mehl‐Avrami (KJMA) kinetics was used to determine scale crystallization rates. Strengths of fibers with glass and with crystalline scales formed by oxidation in dry and wet air between 600° and 1400°C were modeled. The effects of partially crystallized scales were calculated using Weibull statistical methods. Modeled strengths were compared with measurements. Slight strength increases after glass scale formation, large decreases that accompany scale crystallization, and some differences between dry and wet air oxidation were accurately modeled. This suggests that under some conditions the scale residual stress dominates the changes in strength after SiC fiber oxidation. However, modeled strengths were significantly higher than those measured for some fibers oxidized in wet air, which suggests another degradation mechanism is active for these conditions. Modeling assumptions and implications for SiC fiber strength after oxidation for long times are discussed.
Mechanisms of enhanced antiglioma efficacy of polysorbate 80‐modified paclitaxel‐loaded PLGA nanoparticles by focused ultrasound
Authors: Li Yingjia , Wu Manxiang , Zhang Nisi , Tang Caiyun , Jiang Peng , Liu Xin , Yan Fei , Zheng Hairong 
Published: June 2018

AbstractThe presence of blood‐brain barrier (BBB) greatly limits the availability of drugs and their efficacy against glioma. Focused ultrasound (FUS) can induce transient and local BBB opening for enhanced drug delivery. Here, we developed polysorbate 80‐modified paclitaxel‐loaded PLGA nanoparticles (PS‐80‐PTX‐NPs, PPNP) and examined the enhanced local delivery into the brain for glioma treatment by combining with FUS. Our result showed PPNP had good stability, fast drug release rate and significant toxicity to glioma cells. Combined with FUS, PPNP showed a stronger BBB permeation efficiency both in the in vitro and in vivo BBB models. Mechanism studies revealed the disrupted tight junction, reduced P‐glycoprotein expression and ApoE‐dependent PS‐80 permeation collectively contribute to the enhanced drug delivery, resulting in significantly stronger antitumour efficacy and longer survival time in the tumour‐bearing mice. Our study provided a new strategy to efficiently and locally deliver drugs into the brain to treat glioma.
Testing the Dutilleul syndrome: host use drives the convergent evolution of multiple traits in parasitic wasps
Authors: Santos Bernardo F. , Perrard Adrien 
Published: June 2018

AbstractCommon life‐history aspects among independent lineages often result in the repeated evolution of suites of adaptive traits, or ‘syndromes’. Such syndromes can be key avenues to understand relationships between morphological and ecological traits, but are rarely tested due to insufficient trait shift repetitions. We use a hyperdiverse lineage to investigate the evolution of a syndrome. Cryptine ichneumonid wasps that parasitize insects concealed in hard substrates display several traits that are putative adaptations to that end. Using a phylogenetic framework from a combined multigene molecular and morphological data set with 308 cryptine species, we tested whether these traits were part of a morphofunctional syndrome related to host use. Ancestral state estimations show multiple origins for six investigated traits, which are correlated to each other and to the use of deeply concealed hosts, suggesting adaptation. Putatively adaptive traits showed a much stronger link among themselves than with an assemblage of 49 other morphological traits. However, estimation of the order of evolution in adaptive traits showed no structured pattern. The results indicate that the challenge of attacking deeply concealed hosts induced the repeated evolution of a ‘Dutilleul syndrome’, named after the ‘walker‐through‐walls’ character from French literature. They also point towards a dynamic scenario in the evolution of complex functional systems. These findings highlight the power of morphology to illuminate poorly known aspects of natural history, and how hyperdiverse lineages can be used to understand the evolution of complex traits.
Nucleotide‐binding and oligomerization domain (NOD)‐like receptors in teleost fish: Current knowledge and future perspectives
Authors: Zhang Liang , Gao Zhuying , Yu Li , Zhang Bo , Wang Jing , Zhou Jun 
Published: June 2018

AbstractNucleotide‐binding and oligomerization domain (NOD)‐like receptors (NLRs) are a group of intracellular pathogen recognition receptors (PRRs) that play key roles in pathogen recognition and subsequent activation of innate immune signalling pathways. Expressions of several NLR subfamily members, including NOD1, NOD2, NLR‐C3, NLR‐C5 and NLR‐X1 have been reported in many different teleost fish species. These receptors are activated by a variety of ligands, including lipopolysaccharides (LPS), peptidoglycans (PGN) and polyinosinic‐polycytidylic acid [Poly(I:C)]. Synthetic dsRNA and bacterial or viral infections are known to stimulate these receptors both in vitro and in vivo. In this review, we focus on the identification, expression and function of teleost NLRs in response to bacterial or viral pathogens. Additionally, NLR ligand specificity and signalling pathways involved in the recognition of bacterial or viral stimuli are also summarized. This review focuses on current knowledge in this area and provides future perspectives regarding topics in need of additional investigation. Understanding the response of innate immune system to bacterial or viral infections in diverse species could inform the development of more effective therapies and vaccines.
Reproductive cycling in adult baboons (Papio species) that were intrauterine growth restricted at birth implies normal fertility but increased psychosocial stress
Authors: Huber Hillary F. , Considine McKenna M. , Jenkins Susan , Li Cun , Nathanielsz Peter W. 
Published: June 2018

AbstractWe investigated menstrual cycles in intrauterine growth restricted (IUGR, 7‐10 years, n = 8) and age‐matched control (n = 10) baboons. Cycle duration and plasma anti‐Mullerian hormone were similar. IUGR spent more days per cycle swollen and had elevated early morning fasted serum cortisol, suggesting normal fertility in the presence of increased psychosocial stress.
Terminal 13p deletion in squirrel monkey (Saimiri sciureus) with differentiated phenotype
Authors: Goldschmidt B. , Lopes C.A.A. , Resende F. , Pissinatti T.A. , Toledo D.C. , Meireles B.C.S. , Cordeiro N.F.G. 
Published: June 2018

AbstractBackgroundThe taxonomic classification of squirrel monkeys is often controversial issue offering many different information. The classification of captive animals is difficult due to the phenotypic similarities between the presented species, which is observed mainly in coat coloration.MethodsThe objective of this study was to analyze the chromosome pattern of one squirrel monkey with off standard physical characteristics, which is kept in the Laboratory Animals Breeding Center in Rio de Janeiro State, Brazil, and try to establish some correlations. Chromosomes were obtained using lymphocyte culture technique.Results and conclusionsEvaluation of G bands showed a terminal deletion in one chromosome of pair 13. The association of the results found with the different phenotypic characteristics led us to classify it as aSaimiri sciureusspecimen with a structural chromosomal change, possibly allowing the expression of hemizygous alleles.
Japan Society of Obstetrics and Gynecology and Japan Society for Menopause and Women's Health 2017 guidelines for hormone replacement therapy
Authors: Okano Hiroya , Higuchi Tsuyoshi , Kurabayashi Takumi , Makita Kazuya , Mizunuma Hideki , Mochizuki Yoshiko , Obayashi Satoshi , Yasui Toshiyuki , Takamatsu Kiyoshi ,   Subcommittee for Revising the Japanese Guidelines for Hormone Replacement Therapy in the Women's Health Care Committee, Japan Society of Obstetrics and Gynecology
Published: June 2018

AbstractHormone replacement therapy (HRT) plays a large part in maintaining and improving the quality of life (QOL) of postmenopausal women. Despite this obvious role, the use of HRT has stagnated in Japan as well as the United States, since the interim report of the HRT trial of Women's Health Initiative study was published in 2002. The Japan Society of Obstetrics and Gynecology and Japan Society for Menopause and Women's Health formulated the Guidelines for Hormone Replacement Therapy in 2009, which was subsequently revised in 2012, with the aim of organizing perceptions about HRT and allowing people to provide or receive HRT with a sense of security. Later on, in light of changes in indications for HRT and attitudes toward its impact on cancer risks, amendments were made again in 2017. With the establishment of the 2017 guidelines, practitioners in Japan are able to address various issues related to HRT with more appropriate judgment. Moreover, the practice of reliable, safe and effective HRT is expected to promote further efforts toward improvement or maintenance of QOL in patients.
Premaquick© versus modified Bishop score for preinduction cervical assessment at term: A double‐blind randomized trial
Authors: Eleje George U. , Ezugwu Euzebus C. , Ugwu Emmanuel O. , Ezebialu Ifeanyichukwu U. , Eleje Lydia I. , Ojiegbe Nnabuike O. , Ajah Leonard O. , Obiora Chukwudi C. , Egeonu Richard O. , Okafor Chigozie G. , Enyinna Perpetua K. , Egede John O. , Ugochukwu Nzubechukwu J. , Asiegbu Amarachukwu C. , Ikechebelu Joseph I. 
Published: June 2018

AbstractAimTo test whether Premaquick biomarkers were superior to modified Bishop score for preinduction cervical assessment at term.MethodsA multicenter, double‐blind randomized clinical trial in 151 nulliparous, cephalic presenting and singleton pregnancies was conducted. The cervix was considered ‘ripe’ when at least two out of three Premaquick biomarkers are positive or a Bishop score of ≥6. Main outcome measures were proportion of women who were administered or had additional prostaglandin E1 analogue (PGE1) as a preinduction agent and incidence of uterine rupture. The trial was registered in PACTR registry with approval number PACTR201604001592143. Analysis was performed by intention‐to‐treat principle.ResultsThe need for initial PGE1 analogue (77.6% vs 98.7%, risk ratio [RR] =0.47, 95% confidence intervals [95% CI] =0.38–0.59, P < 0.001) and additional PGE1 analogue for cervical ripening after one insertion (44.7% vs 68.0%, RR = 0.63, 95% CI = 0.46–0.86, P = 0.004) was significantly lower in Premaquick group. There was no significant difference in incidence of uterine rupture (0% vs 1.4%, RR = 0.000, P = 0.324); however, the frequency of transition to labor was statistically higher in Premaquick group (44.7% vs 22.7%, RR = 1.59, 95% CI = 1.17–2.15, P = 0.004). Interval from start of induction to any type of delivery, need for oxytocin augmentation, vaginal delivery, number of women with cesarean section for failed induction and number of infants admitted to neonatal intensive care unit were similar between the two groups (P > 0.05).ConclusionPreinduction cervical assessment with Premaquick was significantly associated with higher frequency of transition to labor and reduced need for PGE1 analogue when compared to modified Bishop score. Further similar trials in other settings are necessary to strengthen or refute this observation.
Untargeted UPLC-Q/TOF-MS-based metabolomics and inductively coupled plasma optical emission spectroscopic analysis reveal differences in the quality of ginger from two provinces in Zambia
Authors: Alolga Raphael N , Chavez Maria A S C , Muyaba Moses 
Published: June 2018

Abstract

Objectives
This study sought to investigate the differences in the quality of dried ginger samples obtained from two places in Zambia, Lusaka and Copperbelt in terms of their secondary metabolite differences and heavy metals content.

Methods
Ten and eight batches of dried ginger obtained, respectively, from Lusaka and Copperbelt were analysed using untargeted Q/TOF-MS-based metabolomics and inductively coupled plasma optical emission spectroscopy (ICP-OES).

Key findings
The metabolomics approach yielded 11 differential metabolites that clearly discriminated between the samples from the two locations. Eight were found to be more abundant in the samples from Lusaka while three were present in greater amounts in the samples from Copperbelt. The results of the heavy metal content analysis for four selected elements, Cd, Pb, As and Cu, showed that the samples from Copperbelt recorded higher levels. However, all samples contained levels of the toxic metals, Cd and Pb above permissible limits, making them unwholesome for human consumption.

Conclusions
The outcome of the heavy metal content analysis led us to speculate that abiotic stress as a result of these metals experienced by the ginger rhizomes during cultivation could have contributed to the metabolites abundance differences. Further studies are, however, recommended to verify this hypothesis.
Pseudocayratia, a new genus of Vitaceae from China and Japan with two new species and three new combinations
Authors: Wen Jun , Lu Li‐Min , Hsu Tsai‐Wen , Dang Viet‐Cuong , Habib Sadaf , Boggan John K. , Okada Hiroshi , Chen I‐Ju , Chen Zhi‐Duan 
Published: June 2018

AbstractRecent integrative systematic studies of Vitaceae support the recognition of a new genus Pseudocayratia J.Wen, L.M.Lu & Z.D.Chen. The genus consists of five species from China and Japan. We herein describe the following two new species: Pseudocayratia speciosa J.Wen & L.M.Lu, and P. pengiana Hsu & J.Wen, and make three new combinations: Pseudocayratia dichromocarpa (H.Lév.) J.Wen & Z.D.Chen, P. oligocarpa (H.Lév. & Van.) J.Wen & L.M.Lu, and P. yoshimurae (Makino) J.Wen & V.C.Dang. Phylogenetic analyses based on five chloroplast loci strongly support Pseudocayratia as sister to Tetrastigma. Morphologically, species of the genus have stigmas enlarged (but not 4‐lobed), pedicels at fruiting stage enlarged and fleshy, seeds with a crustaceous thin testa, circular cup‐like ventral infolds, linear chalaza extending ca. 2/3 to 3/4 of the seed length (from apex to base), lateral margin with thin edges, and T‐shaped endosperm in cross‐section. The genus is distributed in eastern Asia (China and Japan). The taxonomic novelties we report in this study at both the generic and species levels highlight the importance of collections‐based research in today's integrative systematics.