bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Uniform Orogen‐parallel Extension System of the Shear Zones in the Tongbai‐Dabie Orogenic Belt, Central China
Authors: LIU Huan , LIN Shoufa , SONG Chuanzhong 
Published: April 2018

AbstractLarge‐scale magmatism affected the Tongbai‐Dabie orogenic belt during post‐collisional lateral tectonic extension in the Cretaceous, which was suggested to account for the widespread deformation and migmatization in the Tongbai‐Dabie complexes. However, it cannot explain the most deformations in the shear zones. The northwest‐southeast shear zones are developed around or wrapped the Tongbai‐Dabie complexes. They play an important role for the interpretation of the tectonic evolution of the Tongbai‐Dabie orogenic belt. By a systematically observation and description of the geometry and kinematics of these shear zones, we found that the shear zones to the north dip NE and have a uniform sinistral shear sense, the shear zone to the south dips SW and has a uniform dextral shear sense, and the shear zones at the core are sub‐horizontal and have a uniform top‐to‐NW sense of shear. Combining with the comparison of previous and our geochronological studies, we interpret these associations as indicating that these shear zones were originally a single, more flat‐lying and sub‐horizontal shear zone with a uniform top‐to‐NW shear sense before the folding‐doming of the Tongbai‐Dabie complexes and suggest that the Tongbai‐Dabie orogenic belt experienced a uniform top‐to‐NW orogen‐parallel extension in the ductile lithosphere before the widespread magmatism in the Cretaceous.
Discovery of the Plagiogranites in the Diyanmiao Ophiolite, Southeastern Central Asian Orogenic Belt, Inner Mongolia, China and Its Tectonic Significance
Authors: LI Yingjie , WANG Jinfang , WANG Genhou , DONG Peipei , LI Hongyang , HU Xiaojia 
Published: April 2018

AbstractIn this study, plagiogranites in the Diyanmiao ophiolite of the southeastern Central Asian Orogenic Belt (Altaids) were investigated for the first time. The plagiogranites are composed predominantly of albite and quartz, and occur as irregular intrusive veins in pillow basalts. The plagiogranites have high SiO2 (74.37–76.68wt%) and low Al2O3 (11.99–13.30wt%), and intensively high Na2O (4.52–5.49wt%) and low K2O (0.03–0.40wt%) resulting in high Na2O/K2O ratios (11.3–183). These rocks are classified as part of the low‐K tholeiitic series. The plagiogranites have low total rare earth element contents (ΣREE)(23.62–39.77ppm), small negative Eu anomalies (δEu=0.44–0.62), and flat to slightly LREE‐depleted chondrite‐normalized REE patterns ((La/Yb)N=0.68–0.76), similar to N‐MORB. The plagiogranites are also characterized by Th, U, Zr, and Hf enrichment, and Nb, P, and Ti depletion, have overall flat primitivemantle‐normalized trace element patterns. Field and petrological observations and geochemical data suggest that the plagiogranites in the Diyanmiao ophiolite are similar to fractionation‐type plagiogranites. Furthermore, the REE patterns of the plagiogranites are similar to those of the gabbros and pillow basalts in the ophiolite. In plots of SREE–SiO2, La–SiO2, and Yb–SiO2, the plagiogranites, pillow basalts, and gabbros show trends typical of crystal fractionation. As such, the plagiogranites are oceanic in origin, formed by crystal fractionation from basaltic magmas derived from depleted mantle, and are part of the Diyanmiao ophiolite. LA–ICP–MS U–Pb dating of zircons from the plagiogranites yielded ages of 328.6±2.1 and 327.1±2.1Ma, indicating an early Carboniferous age for the Diyanmiao ophiolite. These results provide petrological and geochronological evidence for the identification of the Erenhot–Hegenshan oceanic basin and Hegenshan suture of the Paleo‐Asian Ocean.
Fenitized Wall Rock Geochemistry of the First Carbonatite Dyke at Bayan Obo, Inner Mongolia, China
Authors: WANG Kaiyi , ZHANG Jien , YU Liangjun , FANG Aimin , DONG Ce , HU Fuyou 
Published: April 2018

AbstractThe first carbonatite dyke at Bayan Obo is well exposed on the surface for a length and width of approximately 60 m and 1.1–1.5 m, respectively. Along its strike, the fenitized H1 (Qs) and H2 (Cs) quartzite is replaced by Na‐amphiboles, aegirines, and alkali‐feldspars, intermittently stretching as far away as 800 m in length. Based on petrographical characteristics, the dyke's fenitized wall rocks are divisible into different zones: (1) outer, (2) middle, and (3) inner. The outer zone is 5–17 m from the NW margin of the dyke. The middle zone is located at 3.5–5 m from the NW margin of the dyke. The inner contact zone is located between direct contact with the dyke and 3.5 m from the dyke. In the outer zone, upon visual examination, no evidence of outcrop fenitization was found and the major elemental rock composition is nearly identical to the unaltered H1 and H2 lithologies. In the thin sections, however, small amounts of Na‐amphibole and phlogopite are present. Despite relatively poor development throughout the 5 m of fenitization, the wall rocks have retained at least a small geochemical signature comparable to the original sedimentary protolith. The fenites occurring in the inner zone exhibit distinct variations, not only for the sharp contact at the outcrop scale, but also for variations in major, rare earth elements (REE), and trace elements and Sm‐Nd isotope composition. The wall rocks within 3.5 m have undergone strong fenitization, inheriting the geochemical signature derived from the carbonatite dyke. Fenitization in the middle zone was not as strong, at least compared to the inner zone, but was stronger than the outer zone. Compared to some trace elements and REEs, the major elements are relatively immobile during fenitization. The Sm‐Nd isotope data for the carbonatite dyke and the adjacent fenitized wall rocks, where the Sm and Nd originate solely from the dyke, plots as a six‐point isochron with an age of 1308±56 Ma. This age is identical to that of ore‐bearing dolomite carbonatite and the related ore‐forming events, indicating that there may be a petrogenetic link between the two. Based on Sr and Nd isotope compositional data, the first carbonatite dyke may be derived from an enriched mantle.
Occurrence of the Iron–rich Melt in the Heijianshan Iron Deposit, Eastern Tianshan, NW China: Insights into the Origin of Volcanic Rock–hosted Iron Deposits
Authors: LI Houmin , LI Lixing , DING Jianhua , LI Yanhe , SONG Zhe , MENG Jie , MA Yubo 
Published: April 2018

AbstractLong‐standing controversy persists over the presence and role of iron–rich melts in the formation of volcanic rock‐hosted iron deposits. Conjugate iron–rich and silica–rich melt inclusions observed in thin‐sections are considered as direct evidence for the presence of iron‐rich melt, yet unequivocal outcrop‐scale evidence of iron‐rich melts are still lacking in volcanic rock‐hosted iron deposits. Submarine volcanic rock‐hosted iron deposits, which are mainly distributed in the western and eastern Tianshan Mountains in Xinjiang, are important resources of iron ores in China, but it remains unclear whether iron‐rich melts have played a role in the mineralization of such iron ores. In this study, we observed abundant iron‐rich agglomerates in the brecciated andesite lava of the Heijianshan submarine volcanic rock–hosted iron deposit, Eastern Tianshan, China. The iron‐rich agglomerates occur as irregular and angular masses filling fractures of the host brecciated andesite lava. They show concentric potassic alteration with silicification or epidotization rims, indicative of their formation after the wall rocks. The iron‐rich agglomerates have porphyritic and hyalopilitic textures, and locally display chilled margins in the contact zone with the host rocks. These features cannot be explained by hydrothermal replacement of wall rocks (brecciated andesite lava) which is free of vesicle and amygdale, rather they indicate direct crystallization of the iron‐rich agglomerates from iron‐rich melts. We propose that the iron‐rich agglomerates were formed by open‐space filling of volatile‐rich iron‐rich melt in fractures of the brecciated andesite lava. The iron‐rich agglomerates are compositionally similar to the wall‐rock brecciated andesite lava, but have much larger variation. Based on mineral assemblages, the iron‐rich agglomerates are subdivided into five types, i.e., albite‐magnetite type, albite‐K‐feldspar‐magnetite type, K‐feldspar–magnetite type, epidote‐magnetite type and quartz‐magnetite type, representing that products formed at different stages during the evolution of a magmatic‐hydrothermal system. The albite‐magnetite type represents the earliest crystallization product from a residual iron‐rich melt; the albite‐K‐feldspar‐magnetite and K‐feldspar‐magnetite types show features of magmatic‐hydrothermal transition, whereas the epidote‐magnetite and quartz‐magnetite types represent products of hydrothermal alteration. The occurrence of iron‐rich agglomerates provides macroscopic evidence for the presence of iron‐rich melts in the mineralization of the Heijianshan iron deposit. It also indicates that iron mineralization of submarine volcanic rock‐hosted iron deposits is genetically related to hydrothermal fluids derived from iron‐rich melts.
Complex Febrile Seizures, Lumbar Puncture, and Central Nervous System Infections: A National Perspective
Authors: Lee Jane , DeLaroche Amy M. , Janke Alexander T. , Kannikeswaran Nirupama , Levy Phillip D. 
Published: April 2018

AbstractObjectivesThe objective was to determine the national lumbar puncture (LP) practice patterns relative to the incidence of central nervous system (CNS) infections among children presenting to the emergency department (ED) with complex febrile seizures (CFS).MethodsThis was a retrospective study of ED visits for CFS from 2007 to 2014 in patients aged 0 to 5 years using a national sample. Primary outcomes include the frequency of LP, incidence of CNS infections, and ED disposition.ResultsOf 28,810 ED visits for CFS (44.4% female; mean age = 1.39 years), LP was performed in 7,445 (25.8%, 95% confidence interval [CI] 23.5%–28.2%). There was no significant difference in the proportion due to hospital teaching status or geographical region. The proportion decreased from 31.4% to 17.8% over the study period (Rao‐Scott statistic = 5.85, p < 0.001). CNS infection was diagnosed in 80 (0.3%) encounters (95% CI = 41–112). The most commonly associated infections were otitis media (16.8%), upper respiratory infections (15.8%), and other viral infections (14.6%). A total of 14,696 encounters (51.0%, 95% CI = 47.9%–54.1%) resulted in a hospital admission.ConclusionsAlthough rates have been declining, LP was performed in one‐fourth of ED encounters for CFS over the 8‐year study period. The incidence of CNS infections was very low, however, suggesting that this procedure could be avoided in many patients.
Timing of elective pre‐labour caesarean section: A decision analysis
Authors: Wilmink Freke A. , Pham Clarabelle T. , Edge Nicole , Hukkelhoven Chantal W.P.M. , Steegers Eric A.P. , Mol Ben W. 
Published: April 2018

BackgroundSince caesarean sections (CSs) before 39+0 weeks gestation are associated with higher rates of neonatal respiratory morbidity, it is recommended to delay elective CSs until 39+0 weeks. However, this bears the risk of earlier spontaneous labour resulting in unplanned CSs, which has workforce and resource implications, specifically in smaller obstetric units.AimTo assess, in a policy of elective CSs from 39+0 weeks onward, the number of unplanned CSs to prevent one neonate with respiratory complications, as compared to early elective CS.Materials and MethodsWe performed a decision analysis comparing early term elective CS at 37+0–6 or 38+0–6 weeks to elective prelabour CS, without strict medical indication, at 39+0–6 weeks, with earlier unplanned CS, in women with uncomplicated singleton pregnancies. We used literature data to calculate the number of unplanned CSs necessary to prevent one neonate with respiratory morbidity.ResultsPlanning all elective CSs at 39+0–6 weeks required 10.9 unplanned CSs to prevent one neonate with respiratory morbidity, compared to planning all elective CSs at 38+0–6 weeks. Compared to planning all elective CSs at 37+0–6 weeks we needed to perform 3.3 unplanned CSs to prevent one neonate with respiratory morbidity.ConclusionIn a policy of planning all elective pre‐labour CSs from 39+0 weeks of gestation onward, between three and 11 unplanned CSs have to be performed to prevent one neonate with respiratory morbidity. Therefore, in our opinion, fear of early term labour and workforce disutility is no argument for scheduling elective CSs <39+0 weeks.
Teacher beliefs about the aetiology of individual differences in cognitive ability, and the relevance of behavioural genetics to education
Authors: Crosswaite Madeline , Asbury Kathryn 
Published: April 2018

BackgroundDespite a large body of research that has explored the influence of genetic and environmental factors on educationally relevant traits, few studies have explored teachers’ beliefs about, or knowledge of, developments in behavioural genetics related to education.AimsThis study aimed to describe the beliefs and knowledge of UK teachers about behavioural genetics and its relevance to education, and to test for differences between groups of teachers based on factors including years of experience and age of children taught.SampleData were gathered from n = 402 teachers from a representative sample of UK schools. Teachers from primary and secondary schools, and from across the state and independent sectors, were recruited.MethodsAn online questionnaire was used to gather demographic data (gender, age, years of experience, age of children taught, and state vs. independent) and also data on beliefs about the relative influence of nature and nurture on cognitive ability; knowledge of behavioural genetics; openness to genetic research in education; and mindset. Data were analysed using descriptive statistics, ANOVA, correlations, and multiple regression.ResultsTeachers perceived genetic and environmental factors as equally important influences on cognitive ability and tended towards a growth mindset. Knowledge about behavioural genetics was low, but openness to learning more about genetics was high. Statistically significant differences were observed between groups based on age of children taught (openness higher among primary teachers) and state versus independent (more growth‐minded in state sector).ConclusionsAlthough teachers have a limited knowledge of behavioural genetics, they are keen to learn more.
Barriers and facilitators to health care professionals discussing child weight with parents: A meta‐synthesis of qualitative studies
Authors: Bradbury Daisy , Chisholm Anna , Watson Paula M. , Bundy Christine , Bradbury Nicola , Birtwistle Sarah 
Published: April 2018

IntroductionChildhood obesity is one of the most serious global public health challenges. However, obesity and its consequences are largely preventable. As parents play an important role in their children's weight‐related behaviours, good communication between parents and health care professionals (HCPs) is essential. This systematic review provides a meta‐synthesis of qualitative studies exploring the barriers and facilitators experienced by HCPs when discussing child weight with parents.MethodsSearches were conducted using the following databases: MEDLINE (OVID), Psych INFO (OVID), EMBASE (OVID), Web of Knowledge and CINAHL. Thirteen full‐text qualitative studies published in English language journals since 1985 were included. Included studies collected data from HCPs (e.g., nurses, doctors, dieticians, psychologists, and clinical managers) concerning their experiences of discussing child weight‐related issues with parents. An inductive thematic analysis was employed to synthesize findings.FindingsEmerging subthemes were categorized using a socio‐ecological framework into intra/interpersonal factors, organizational factors, and societal factors. Perceived barriers and facilitators most commonly related to intra/interpersonal level factors, that is, relating to staff factors, parental factors, or professional–parent interactions. HCPs also attributed a number of barriers, but not facilitators, at the organizational and societal levels.ConclusionThe findings of this review may help to inform the development of future weight‐related communication interventions. Whilst intra/interpersonal interventions may go some way to improving health care practice, it is crucial that all stakeholders consider the wider organizational and societal context in which these interactions take place.
Statement of contribution

What is already known on the subject?

Childhood obesity is one of the United Kingdom's most serious current public health challenges.

Health care professionals are in a prime position to identify child weight issues during routine consultations.

However, they often feel unable or unequipped to raise the topic and provide information on child weight management.

What does this study add?

To our knowledge, this is the first review to synthesize barriers and facilitators to discussing child weight.

This review interprets key barriers and facilitators in the context of the socio‐ecological model.

Supports the development of interventions matched to the appropriate level of the socio‐economic model.
The zircon story of the Nile: Time‐structure maps of source rocks and discontinuous propagation of detrital signals
Authors: Garzanti Eduardo , Vermeesch Pieter , Rittner Martin , Simmons Matthew 
Published: April 2018

AbstractA new dimension has recently been added to provenance analysis by the rapid development of detrital‐geochronology techniques. The application of any dating method to sediments allows the definition of a unique age pattern of parent rocks, a “time structure” that represents an essential complement to the information on their lithological structure obtained by traditional petrographic and mineralogical methods. This detrital‐geochronology study illustrates the distribution of U‐Pb zircon ages in all parts of the Nile catchment from its equatorial headwaters to the Delta, and surveys how the provenance signal is formed, transmitted, and modified along this huge sediment‐routing system. Age‐spectra obtained by targeting specific parts of zircon grains after cathodo‐luminesce imaging and by our Automated Phase Mapping + LAICPMS “blind‐dating strategy” were compared. The former approach emphasises specific magmatic or metamorphic events in source areas, whereas the latter aims at minimising selection bias and focuses on consistency among samples. Grain‐size and hydraulic‐sorting controls were also checked, but found to have only a minor effect on zircon‐age distributions. The trimodal age spectrum of Kagera zircons sourced from the rift highlands of Burundi and Rwanda, characterised by prominent late Neoarchean (Aruan) and mid‐Mesoproterozoic (Kibaran) peaks with a wider mid‐Palaeoproterozoic (Ubendian) cluster, is lost in the Lake Victoria sediment sink. The sharp unimodal Aruan peak displayed by zircon grains in both Victoria and Albert Nile is supplemented and finally superseded by Neoproterozoic grains across the vast marshlands of South Sudan, where detritus produced in equatorial regions is eventually stored. All Nile tributaries in Sudan and Egypt carry zircon grains yielding predominantly Neoproterozoic ages, with a major peak around 0.6 Ga associated with clusters around 0.8 and 1.0 Ga. A few Oligocene zircons represent the key diagnostic feature of Ethiopian provenance, the Ariadne's golden thread that allowed retracing the palaeo‐Nile to its Ethiopian sources back in the Oligocene. The Nile presents a text‐book case of discontinuous transmission of provenance signals along a segmented ultra‐long drainage system. Zircon‐age fingerprints as well as all other detrital signatures are lost repeatedly in large Ugandan lakes, reconstituted or replaced, lost again in the vast marshlands of South Sudan, and finally homogenised downstream from Ethiopia and Sudan to the Mediterranean Sea.
Individualized predictive signatures for 5‐fluorouracil‐based chemotherapy in right‐ and left‐sided colon cancer
Authors: Song Kai , Zhao Wenyuan , Wang Wen , Zhang Na , Wang Kai , Chang Zhiqiang 
Published: April 2018

5‐Fluorouracil (5‐FU)‐based adjuvant chemotherapy (ACT) is widely used for the treatment of colon cancer. Colon cancers with different primary tumor locations are clinically and molecularly distinct, implied through their response to 5‐FU‐based ACT. In this work, using 69 and 133 samples of patients with stage II‐III right‐sided and left‐sided colon cancer (RCC and LCC) treated with post‐surgery 5‐FU‐based ACT, we preselected gene pairs whose relative expression orderings were significantly correlated with the disease‐free survival of patients by univariate Cox proportional hazards model. Then, from the identified prognostic‐related gene pairs, a forward‐stepwise selection algorithm was formulated to search for an optimal subset of gene pairs that resulted in the highest concordance index, referred to as the gene pair signature (GPS). We identified prognostic signatures, 3‐GPS and 5‐GPS, for predicting response to 5‐FU‐based ACT of patients with RCC and LCC, respectively, which were validated in independent datasets of GSE14333 and GSE72970. With the aid of the signatures, the transcriptional and genomic characteristics between the predicted responders and non‐responders were explored. Notably, both in RCC and LCC, the predicted responders to 5‐FU‐based ACT were characterized by hypermutation, whereas the predicted non‐responders were characterized by frequent copy number alternations. Finally, in comparison with the established relative expression ordering‐based signature, which was developed without considering the differences between RCC and LCC, the newly proposed signatures had a better predictive performance. In conclusion, 3‐GPS or 5‐GPS can robustly predict response to 5‐FU‐based ACT for patients with RCC or LCC, respectively, in an individual level.
Collagen type I induces EGFR‐TKI resistance in EGFR‐mutated cancer cells by mTOR activation through Akt‐independent pathway
Authors: Yamazaki Shota , Higuchi Youichi , Ishibashi Masayuki , Hashimoto Hiroko , Yasunaga Masahiro , Matsumura Yasuhiro , Tsuchihara Katsuya , Tsuboi Masahiro , Goto Koichi , Ochiai Atsushi , Ishii Genichiro 
Published: April 2018

Primary resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) is a serious problem in lung adenocarcinoma patients harboring EGFR mutations. The aim of this study was to examine whether and how collagen type I (Col I), the most abundantly deposited matrix in tumor stroma, affects EGFR‐TKI sensitivity in EGFR‐mutant cells. We evaluated the EGFR‐TKI sensitivity of EGFR‐mutated cancer cells cultured with Col I. Changes in the activation of downstream signaling molecules of EGFR were analyzed. We also examined the association between the Col I expression in tumor stroma in surgical specimens and EGFR‐TKI response of postoperative recurrence patients with EGFR mutations. Compared to cancer cells without Col I, the survival rate of cancer cells cultured with Col I was significantly higher after EGFR‐TKI treatment. In cancer cells cultured with and without Col I, EGFR‐TKI suppressed the levels of phosphorylated (p‐)EGFR, p‐ERK1/2, and p‐Akt. When compared to cancer cells without Col I, expression of p‐P70S6K, a hallmark of mTOR activation, was dramatically upregulated in cancer cells with Col I. This activation was maintained even after EGFR‐TKI treatment. Simultaneous treatment with EGFR‐TKI and mTOR inhibitor abrogated Col I‐induced resistance to EGFR‐TKI. Patients with Col I‐rich stroma had a significantly shorter progression‐free survival time after EGFR‐TKI therapy (238 days vs 404 days; P < .05). Collagen type I induces mTOR activation through an Akt‐independent pathway, which results in EGFR‐TKI resistance. Combination therapy using EGFR‐TKI and mTOR inhibitor could be a possible strategy to combat this resistance.