bluuebunny/crossref_metadata_2025_split huggingface dataset:
ClarIDHy: A phase 3 multicenter randomized double-blind study of AG-120 versus placebo in patients with non-resectable or metastatic cholangiocarcinoma with an IDH1 mutation.
Authors: Abou-Alfa Ghassan K. , Valle Juan W. , Kelley Robin Kate , Goyal Lipika , Shroff Rachna T. , Javle Milind M. , Borad Mitesh J. , Cleary James M. , El-Khoueiry Anthony B. , Bendell Johanna C. , Macarulla Teresa Mercade , Vogel Arndt , Korth Christopher , Jiang Liewen , Gliser Camelia , Wu Bin , Agresta Samuel V. , Pandya Shuchi Sumant , Zhu Andrew X. 
Published: January 2019

TPS545 Background: Advanced cholangiocarcinoma (CC) is a life-threatening disease with limited effective chemotherapy options. Mutations in isocitrate dehydrogenase 1 (mIDH1) occur in 13–15% of CC cases, and up to 25% of intrahepatic CC cases, leading to epigenetic and genetic changes that promote oncogenesis via production of the oncometabolite 2-hydroxyglutarate (2-HG). AG-120 (ivosidenib), a first-in-class oral mIDH1 inhibitor, displayed a favorable safety profile and clinical activity in a phase 1 study enrolling 73 mIDH1 CC patients who had received ≥1 prior systemic regimen. As of 10 Mar 2017, 4/73 (5%) had a partial response and 41/73 (56%) stable disease. Progression free survival (PFS) rates at 6 months and 12 months were 38.5% and 20.7%, respectively. The 500 mg once daily dose level of AG-120 was selected for further development in mIDH1 CC. Methods: ClarIDHy is a global, phase 3, multicenter, double-blind, randomized (2:1) study of AG-120 (500 mg once daily) vs. matched placebo in 186 mIDH1 CC patients (ClinicalTrials.gov NCT02989857). Key eligibility criteria: non-resectable or metastatic CC, documented mIDH1 by central laboratory testing, ECOG performance status 0–1, measurable disease (RECIST v1.1), documented disease progression after ≤2 prior systemic therapies in the advanced setting including at least 1 gemcitabine- or 5-fluorouracil-containing regimen, and no prior mIDH inhibitor therapy. Crossover from placebo to AG-120 will be allowed at time of radiographic disease progression. Primary endpoint: PFS assessed by independent radiologists. Secondary endpoints: safety, tolerability, overall response rate (RECIST 1.1), overall survival, pharmacokinetic/pharmacodynamic analyses, and quality of life (EORTC QLQ-C30 and QLQ-BIL21 scales). An independent data monitoring committee will monitor the data during study conduct. The ClarIDHy study is currently activated at participating sites in the US, UK, EU, and S. Korea. R eused with permission from the American Society of Clinical Oncology (ASCO). This abstract was accepted and previously presented at the 2017 ASCO Annual Meeting. All rights reserved. Clinical trial information: NCT02989857.
Understanding the Average Impact of Microcredit Expansions: A Bayesian Hierarchical Analysis of Seven Randomized Experiments
Authors: Meager Rachael 
Published: January 2019

Despite evidence from multiple randomized evaluations of microcredit, questions about external validity have impeded consensus on the results. I jointly estimate the average effect and the heterogeneity in effects across seven studies using Bayesian hierarchical models. I find the impact on household business and consumption variables is unlikely to be transformative and may be negligible. I find reasonable external validity: true heterogeneity in effects is moderate, and approximately 60 percent of observed heterogeneity is sampling variation. Households with previous business experience have larger but more heterogeneous effects. Economic features of microcredit interventions predict variation in effects better than studies’ evaluation protocols. (JEL D14, G21, I38, O12, O16, P34, P36)
World Literature in Estonia: the Construction of National Translation Ethics
Authors: Kaldjärv Klaarika , Gielen Katiliina 
Published: January 2019

In addition to many other functions, translating may (and often does) also have a national agenda. Such agenda determines what is going to be translated, how and by whom. Depending on what the national agenda might be, various questions of ethics come into play. Such questions of ethics may be reflected in the translation norms, they may be concealed but still have an important role in constructing the image of translators as well as the idea of what translations should be like.
In Estonia, translation has been of pivotal importance among other things in the formation of the national canon and in developing the Estonian language. In addition to that, translation can be considered to be a means of implementing new ideologies as well as means of resistance. In the present paper, we will ask questions rather than try to answer them: What does ethics of translation mean in the Estonian cultural context? Considering Estonian translation history, can translation ethics be said to be dependent on a particular historical-political situation? And, who has the right to judge translations and the activity of translators?
Literary Creativity and Transgeniality
Authors: Talvet Jüri 
Published: January 2019

There is hardly any doubt that most turning points in the history of small and minor literatures have been provoked from the outside, in the first place under direct influence of some new current engendered and spread from “centers”, traditionally identified with major nations and linguistic communities. As compared with small nations, creative cultures of “centers” have historically enjoyed much more freedom, because (more than often) under the coverage of political-economic and military might they have been able to develop without looming existential threats from the outside.
At the same time, no culture is inherently homogeneous. Especially since the Modern Age conformist and rebellious creativity have been in a constant state of confrontation as well as mutual interactivity. Therefore, the history of cultural creativity is full of paradoxes and surprises, both in “centers” and “peripheries”. Creative culture has nearly always retained at least a relative independence, in regard to the official society with its material power and business structures.
I would like to show that beyond a huge number of intertextualities extending from “centers” to “peripheries” (the physical and mental locus of small and minor cultures), easily traceable in formal and external signs of literary works, there exists in parallel a phenomenon which could be tentatively defined as “transgeniality”.
I will try to reveal some of such transgenialities comparing the poetics and philosophy of (mainly) three poets, the Spaniard Antonio Gamoneda (born in 1931), the Yi-Chinese poet Jidi Majia (born in 1961) and the Estonian poet Juhan Liiv (1864–1913).
Patellofemoral arthroplasty versus total knee arthroplasty for patients with patellofemoral osteoarthritis
Authors: Clement N. D. , Howard T. A. , Immelman R. J. , MacDonald D. , Patton J. T. , Lawson G. M. , Burnett R. 
Published: January 2019

Aims The primary aim of this study was to compare the knee-specific functional outcome of patellofemoral arthroplasty with total knee arthroplasty (TKA) in the management of patients with patellofemoral osteoarthritis. Patients and Methods A total of 54 consecutive Avon patellofemoral arthroplasties were identified and propensity-score-matched to a group of 54 patients undergoing a TKA with patellar resurfacing for patellofemoral osteoarthritis. The Oxford Knee Score (OKS), the 12-Item Short-Form Health Survey (SF-12), and patient satisfaction were collected at a mean follow up of 9.2 years (8 to 15). Survival was defined by revision or intention to revise. Results There was no significant difference in the mean OKS (p > 0.60) or SF-12 scores (p > 0.28) between the groups. There was a lower rate of satisfaction at the final follow-up for the TKA group (78% vs 87%) but this was not statistically significant (odds ratio 0.56, p = 0.21). Length of stay was significantly shorter (p = 0.008) for the Avon group (difference 1.8 days, 95% confidence interval (CI) 0.4 to 3.2). The ten-year survival for the Avon group was 92.3% (95% CI 87.1 to 97.5) and for the TKA group was 100% (95% CI 93.8 to 100). This difference was not statistically significant (log-rank test, p = 0.10). Conclusion Patients undergoing an Avon patellofemoral arthroplasty have a shorter length of stay, and a functional outcome and rate of satisfaction that is equal to that of TKA. The benefits of the Avon arthroplasty need to be balanced against the increased rate of revision when compared with TKA.
The influence of preoperative psychological distress on pain and function after total knee arthroplasty
Authors: Sorel J. C. , Veltman E. S. , Honig A. , Poolman R. W. 
Published: January 2019

Aims We performed a meta-analysis investigating the association between preoperative psychological distress and postoperative pain and function after total knee arthroplasty (TKA). Materials and Methods Pubmed/Medline, Embase, PsycINFO, and the Cochrane library were searched for studies on the influence of preoperative psychological distress on postoperative pain and physical function after TKA. Two blinded reviewers screened for eligibility and assessed the risk of bias and the quality of evidence. We used random effects models to pool data for the meta-analysis. Results Six prospective cohort studies, with a total of 1525 patients, were included. The random effects models showed significantly poorer outcomes in patients who preoperatively had elevated scores on the pain catastrophizing scale, worse 36-Item Short-Form Health Survey (SF-36) mental health score, symptoms of anxiety and/or depression, and somatization dysfunction. After 12 months, the standard mean difference for pain was −0.74 (95% confidence interval (CI) −1.04 to −0.44) and −0.56 (95% CI −0.80 to −0.32) for function. Conclusion Preoperative pain catastrophizing, mental distress, symptoms of anxiety and/or depression, and somatoform disorders appear to adversely affect pain and function after TKA. Some patients undergoing TKA may therefore need psychological support to improve the outcome and quality of life.
Reduced Testicular Steroidogenesis and Increased Semen Oxidative Stress in Male Partners as Novel Markers of Recurrent Miscarriage
Authors: Jayasena Channa N , Radia Utsav K , Figueiredo Monica , Revill Larissa Franklin , Dimakopoulou Anastasia , Osagie Maria , Vessey Wayne , Regan Lesley , Rai Rajendra , Dhillo Waljit S 
Published: January 2019

AbstractBACKGROUNDRecurrent pregnancy loss, (RPL) affecting 1%–2% of couples, is defined as ≥3 consecutive pregnancy losses before 20-week' gestation. Women with RPL are routinely screened for etiological factors, but routine screening of male partners is not currently recommended. Recently it has been suggested that sperm quality is reduced in male partners of women with RPL, but the reasons underlying this lower quality are unclear. We hypothesized that these men may have underlying impairments of reproductive endocrine and metabolic function that cause reductions in sperm quality.METHODSAfter ethical approval, reproductive parameters were compared between healthy controls and male partners of women with RPL. Semen reactive oxygen species (ROS) were measured with a validated inhouse chemiluminescent assay. DNA fragmentation was measured with the validated Halosperm method.RESULTSTotal sperm motility, progressive sperm motility, and normal morphology were all reduced in the RPL group vs controls. Mean ±SE morning serum testosterone (nmol/L) was 15% lower in RPL than in controls (controls, 19.0 ± 1.0; RPL, 16.0 ± 0.8; P &lt; 0.05). Mean ±SE serum estradiol (pmol/L) was 16% lower in RPL than in controls (controls, 103.1 ± 5.7; RPL, 86.5 ± 3.4; P &lt; 0.01). Serum luteinizing hormone and follicle-stimulating hormone were similar between groups. Mean ±SE ROS (RLU/sec/106 sperm) were 4-fold higher in RPL than in controls (controls, 2.0 ± 0.6; RPL, 9.1 ± 4.1; P &lt; 0.01). Mean ±SE sperm DNA fragmentation (%) was 2-fold higher in RPL than in controls (controls, 7.3 ± 1.0; RPL, 16.4 ± 1.5; P &lt; 0.0001).CONCLUSIONSOur data suggest that male partners of women with RPL have impaired reproductive endocrine function, increased levels of semen ROS, and sperm DNA fragmentation. Routine reproductive assessment of the male partners may be beneficial in RPL.
The Vaginal Microbiome of Transgender Men
Authors: Winston McPherson Gabrielle , Long Thomas , Salipante Stephen J , Rongitsch Jessica A , Hoffman Noah G , Stephens Karen , Penewit Kelsi , Greene Dina N 
Published: January 2019

Abstract

BACKGROUND
Hormonal changes influence the composition of vaginal flora, which is directly related to the health of an individual. Transgender men prescribed testosterone experience a vaginal hormone composition that differs from cisgender women. To the author's knowledge, there are no clinical studies evaluating the influence that testosterone administration has on the vaginal microbiome.

METHODS
Vaginal swabs were self-collected by a cohort of self-identified healthy transgender men prescribed testosterone for at least 1 year (n = 28) and from cisgender women who were used as the comparator (n = 8). Participants completed a questionnaire to indicate the mode and dose of testosterone administration, sexual history, and vaginal health. Serum was collected for hormone analysis. Bacterial community profiles were assessed with broad-range PCR primers targeting the V3–V4 hypervariable region of the 16S bacterial rRNA, next-generation sequencing, and analysis by phylogenetic placement.

RESULTS
Compared to cisgender women, the vaginal floras of transgender men were less likely to have Lactobacillus as their primary genus. Intravaginal estrogen administration was positively associated with the presence of Lactobacillus in transgender men (P = 0.045). Transgender men had a significantly increased relative abundance of &gt;30 species and a significantly higher α diversity (P = 0.0003). The presence of Lactobacillus was significantly associated with a lower α diversity index (P = 0.017).

CONCLUSIONS
The vaginal microbiome of transgender men who were assigned a female sex at birth and use testosterone may differ from that of cisgender women. Intravaginal estrogen administration may reduce these differences by promoting colonization with Lactobacillus species and decreasing α diversity.
Simmering with rage: Kitchens and intimate partner violence in Eva Sørhaug’s 90 Minutes
Authors: Gjellstad Melissa 
Published: January 2019

Abstract
This article examines domestic violence committed by white heterosexual men in a 2010s Norwegian film by a female director. This film stands out for its focus on male perpetrators, not female victims, contributing a fictional presentation of three men who struggle to meet societal norms for parents and partners in the Nordic gender-equal family of the twenty-first century. Eva Sørhaug’s use of cinematic space drills deep to probe the men’s pain, employing both the camera’s perspective and the significance of interiors of family homes to visually assess the male characters as they break. The socially constructed spaces of the kitchen and the bedroom augment tensions within the rigid confines of hegemonic masculinity and the men’s failure to attain those norms. The cinematic portrayal of intimate partner violence and homicide sheds light on male perpetrators and invokes societal culpability in the perpetuation of abuse.
Sexual violence, good taste and the education of the cinema audience: Gender and censorship in 1920s Sweden
Authors: Gustafsson Tommy , Larsson Mariah 
Published: January 2019

Abstract
This article makes use of records in the archive of Sweden’s National Board of Film Censorship for a discussion of the censorship of visual representations of sex and violence in films by women directors during the 1920s. From the perspective that Swedish film censorship was utilized to educate and control Swedish cinema audiences, not least concerning taste, the question is posed: how did gender and nationality play a role in the assessment of taste? Focusing on three case studies, namely Karin Swanström’s Kalle Utter (1925), Dorothy Arzner’s Manhattan Cocktail (1928) and Olga Preobrazhenskaya’s The Women of Ryazan (1927) and comparing censorship records with reviews in the daily press, the article demonstrates how nation played a role in the assessment of taste and the decisions to cut these films. The analyses also reveal that the censoring of sexual violence had a tendency to diminish acts such as rape and forced kissing in a narrative as well as on a moral level.
Large Abdominal Defect Closure: Case Series
Authors: Handini Nurliati Sari , Tiza Melina , Sudjatmiko Gentur 
Published: January 2019

Background: We will report some experiences in managing challenging malignant cases on the abdominal wall, including a case of large, irradiated defect. All of those cases were consulted intraoperative immediately following tumor removal. The keystone random perforator flap was chosen among the option of solutions in large abdominal defect closure. This region has natural elasticity, which combines well with the multi-axial tissue recruitment of the flap
Methods: Three cases of complicated abdominal defect were reconstructed using the keystone flaps supplied by non-identified (random) perforators.
Results: All flaps survived without problem of vascularization, despite of its large defect, sequence of radiotherapy following reconstruction, infection, and with its margin unable to be freed from tumor. One out of three cases suffered from contaminated wound from stomal leakage, leading to dehiscence.
Conclusion: The keystone flap is a useful and reliable random perforator-based flap, even in complex and challenging malignant cases of abdominal wall.
Simple Metric Measurement To Choose A keystone Flap Design On Extremities: A Cadaveric Study
Authors: Hariwangsa Narottama Tunjung , Sudjatmiko Gentur 
Published: January 2019

Background: Closing defect on extremities can be challenging because of limited donor area in order to obtain similar quality, color, texture, and adequate size with the defect. The keystone flap has gained popularity as a tool for local reconstruction because of its simple design, short operative time, good aesthetic outcome, and cost-effective wound closure. The aim of this study is to introduce a method in choosing a keystone flap design based on simple metric measurement resulting in lower tension..
Methods: Four circular defects were created on 4 different regions of a fresh cadaver’s upper limbs. Diameters were 5 cm for upper arms and 3 cm for lower arms. Two options of keystone flaps designs were introduced. The keystone could be advanced in longitudinal manner or in transversal manner according to limb’s axis. We then calculated the percentage of the skin required to stretch, in order to close the defects. The less percentage of skin required to stretch between the two manners indicated the lower tension of the keystone flap.
Results: Measurements in all of 4 regions of upper limbs showed that the percentage of skin stretch in closing the defects was lower in longitudinal advancement keystone flap compared to transversal advancement (19.88% versus 27.8% for upper arms and 15.71% versus 21.67% for lower arms)
Conclusion: Simple metric measurements in choosing a keystone flap can be applied to defects on extremities. With less tension when raising the keystone flap, acceptable scar is expected and the occurrence of contracture and flap necrosis can be reduced.
Surgery and Rehabilitation Following Flexor Tendon Zone II Injury Of The Hand: A Literature Review
Authors: Lumintang Loelita Marcelia , Nata’atmadja Beta Subakti 
Published: January 2019

Background : Flexor tendon injury of the hand is common and it used to end up with poor outcomes. It gives negative effects to patient’s daily life. Successful treatment for these cases is a challenge for surgeons. Before 1967, Injury in Zone II was called as “No Man’s Land”. Flexor tendon repair and rehabilitation have been substantially improved through advances in repair and rehabilitation. Method : We reviewed literatures from PubMed, MEDLINE, Cochrane and Google Scholar. It was researched using the terms flexor tendon zone II injury, flexor tendon zone II repair and flexor tendon zone II rehabilitation. Topics covered included anatomy, suture repair and material, and rehabilitation. Result : There is no significant difference of rupture rates and functional outcomes in the number of core suture. Braided polyester suture is the choice for core suture and monofilament for peripheral suture. There is no significant difference in rehabilitation using early passive motion or early active motion. The preference for post operative treatment is by using short splint without immobilization of the wrist. Discussion : Repair sutures techniques and suture materials have been improved as well as active mobilization rehabilitation protocols including a change of wrist position by modification of splints. Improvement in putting splint from a traditional dorsal blocking splint into splint that not immobilize the wrist. Despite all of these modifications, tendon ruptures have not been eliminated. The definitive answer remains elusive.
Tetrapod Fracture: Surgical Anatomy Revisited As A Guide For 3D Reduction Using Carroll Girard T-Bar Screw
Authors: Kreshanti Prasetyanugraheni , Gianni Livia Faranita 
Published: January 2019

Background: Zygomaticomaxillary complex plays a key role in the structure, function, and aesthetic appearance of the facial skeleton. Using Carroll Girard T-bar screw allows easy manipulation of the zygomaticomaxillary complex fracture. The goal of the treatment is three dimensional (3-D) restoration of the disturbed anatomy.
Methods: After exposing the fracture sites using technique such as lower eyelid, Dingman (lateral brow) or maxillary vestibular approach, the Carroll Girard T-bar screw is then attached to the lateral aspect of the malar eminence to freely move the zygoma according to the x,y, and z axis. Zygomaticosphenoid suture acts as the anatomical landmark for adequate reduction.
Conclusion: Open reduction and internal fixation is the principle of management in displaced ZMC fractures, aided by the use of Carroll Girard T-bar screw which allows easy manipulation and rotation for the zygomatic bone using the reference axis x, y and z.
Parity As A Risk Factor Of Children With Cleft Lip
Authors: Widayanti Nurina , Danila Amira , Syohanda Wahyu Indra 
Published: January 2019

Background: Cleft lip and palate is one of the most common congenital anomalies with the prevalence of 1 case for every 1000 birth. Nulliparity has been associated with increased of many birth defects. In contrast, multiparity has also been associated with several birth defects.
Methods: This case-control study compares data from 74 cleft lip patients who was enrolled in Gentur Cleft Foundation to those of 87 normal children. The dependent variable of this study was the incidence of CL/P (cleft lip with or without cleft palate) and the independent variables were maternal parity. Binary logistic regression was used to analyze crude and adjusted OR. Nulliparous mothers were treated as the reference category.
Result: Compared to nulliparous mothers, primiparous mothers has OR 1.57 (95%CI=0.78-3.2). While multiparous mothers has OR 27.54 (95%CI=3.5-216.32). P-value was insignificant for the association of primiparous mothers with CL/P
Conclusion: We observe higher incidence of multiparous mothers with the incidence of CL/P compared to nulliparous mothers.