bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Paternal Age at Conception on Human Health
Authors: Simard Mathieu , Laprise Catherine , Girard Simon L 
Published: January 2019

Abstract

BACKGROUND
The effect of maternal age at conception on various aspects of offspring health is well documented and often discussed. We seldom hear about the paternal age effect on offspring health, although the link is now almost as solid as with maternal age. The causes behind this, however, are drastically different between males and females.

CONTENT
In this review article, we will first examine documented physiological changes linked to paternal age effect. We will start with all morphological aspects of the testis that have been shown to be altered with aging. We will then move on to all the parameters of spermatogenesis that are linked with paternal age at conception. The biggest part of this review will focus on genetic changes associated with paternal age effects. Several studies that have established a strong link between paternal age at conception and the rate of de novo mutations will be reviewed. We will next discuss paternal age effects associated with telomere length and try to better understand the seemingly contradictory results. Finally, severe diseases that affect brain functions and normal development have been associated with older paternal age at conception. In this context, we will discuss the cases of autism spectrum disorder and schizophrenia, as well as several childhood cancers.

SUMMARY
In many Western civilizations, the age at which parents have their first child has increased substantially in recent decades. It is important to summarize major health issues associated with an increased paternal age at conception to better model public health systems.
Male Contraceptive Development: Update on Novel Hormonal and Nonhormonal Methods
Authors: Long Jill E , Lee Min S , Blithe Diana L 
Published: January 2019

AbstractBACKGROUNDDevelopment of new methods of male contraception would address an unmet need for men to control their fertility and could increase contraceptive options for women. Pharmaceutical research and development for male contraception was active in the 1990s but has been virtually abandoned. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has supported a contraceptive development program since 1969 and supports the majority of hormonal male contraceptive development. Nonhormonal methods are also in development but are at earlier stages.CONTENTSeveral hormonal male contraceptive agents have entered clinical trials. Single-agent products being evaluated include dimethandrolone undecanoate, 11β-methyl-nortestosterone dodecyl carbonate, and 7α-methyl-19-nortestosterone. A contraceptive efficacy trial of Nestorone® gel and testosterone gel in a single application will begin in 2018. Potential nonhormonal methods are at preclinical stages of development. Many nonhormonal male contraceptive targets that affect either sperm production or sperm function have been identified. Targeted pathways include the retinoic acid pathway, bromodomain and extraterminal proteins, and pathways for Sertoli cell–germ cell adhesion or sperm motility. Druggable targets include CatSper, the sperm Na+/K+-exchanger, TSSK, HIPK4, EPPIN, and ADAMs family proteins. Development of a procedure to reversibly block the vas deferens (initially developed in India in the 1980s) is undergoing early stage research in the US under the trade name Vasalgel™.SUMMARYNICHD has supported the development of reversible male contraceptive agents. Other organizations such as the World Health Organization and the Population Council are pursuing male contraceptive development, but industry involvement remains dormant.
Osteoprotegerin is Higher in Sepsis Than in Noninfectious SIRS and Predicts 30-Day Mortality of SIRS Patients in the Intensive Care
Authors: Kemperman Hans , Schrijver Irene T , Roest Mark , Kesecioglu Jozef , van Solinge Wouter W , de Lange Dylan W 
Published: January 2019

AbstractBackgroundSystemic inflammatory response syndrome (SIRS) is a complex disease involving multiple pathways and organs. Biomarkers reflecting these pathways and organ function could correlate with the severity of the disease. Osteoprotegerin (OPG), mainly known for its role in bone metabolism, is also involved in the immune and vascular system and is therefore an interesting biomarker to study in SIRS patients. In this prospective observational study, we investigated the correlation of plasma OPG concentrations, sepsis, and 30-day mortality of SIRS patients in the intensive care unit (ICU).MethodsThis observational, single-center, cohort study included 313 consecutive patients admitted to the ICU, with an anticipated stay of more than 48 h and SIRS on admission. Data from included patients were collected daily until discharge or death for a maximum of 10 days. Thirty-day mortality was retrospectively assessed. OPG concentrations were measured in the first 48 h after admission. The relation of OPG with no sepsis, sepsis, and septic shock was assessed with the Kruskal–Wallis test and the Mann–Whitney U-test. Cox proportional hazards regression was used to study OPG concentrations and 30-day mortality.ResultsOPG concentrations were higher in patients with sepsis and septic shock than in patients without sepsis. Furthermore, patients with OPG concentrations in the highest tertile at admission in the ICU have an increased risk of mortality within 30 days when compared to patients with OPG concentrations in the lowest and middle tertiles, independent of acute physiologic and chronic health evaluation (APACHE) and sequential organ failure assessment (SOFA) scores.ConclusionsWe show that OPG is a biomarker that correlates with sepsis and predicts mortality of SIRS patients in the ICU.
AVALIAÇÃO IN VITRO DO FATOR DE PROTEÇÃO SOLAR (FPS) DE COSMÉTICOS FOTOPROTETORES MANIPULADOS
Authors: Secco Gabriela Gislaine , Beltrame Betina Montanari , Schwanz Melissa 
Published: January 2019

Visando reduzir os efeitos nocivos causados na pele pela radiação solar, a utilização de fotoprotetores é uma realidade. Com base na importância do tema, o objetivo dessa pesquisa foi determinar experimentalmente, por espectrofotometria na região do ultravioleta, o fator de proteção solar (FPS) e, ainda, avaliar características macroscópicas e físico-químicas de fotoprotetores manipulados rotulados FPS 30, além de evidenciar a possibilidade de determinação do FPS pela técnica in vitro para controle da qualidade em as farmácias magistrais. Os resultados mostraram que as formulações se apresentaram visivelmente homogêneas, de coloração normal, odor característico e toque agradável. O pH manteve-se na faixa de 6,30 a 7,66. No teste de estabilidade por centrifugação uma das amostras apresentou leve evidência de falta de homogeneidade e as demais não apresentaram qualquer alteração em relação ao seu aspecto original. Quanto ao FPS in vitro, uma das formulações em estudo obteve valor acima do rotulado e as demais obtiveram FPS inferiores aos declarados nos rótulos. A avaliação in vitro utilizada no trabalho pode contribuir para a determinação e controle de produtos manipulados, por ser uma técnica confiável e de fácil execução.
Detailization of the Facial Conditions for Sedimentation of the 〖Yu〗_1^2 Productive Layer with the Purpose of Specificating Features of the Geological Structure
Authors: ALEKSANDROV SorinVadim M. , MOROZOV Alexander V. , POPOV Ivan P. , LEBEDEVA Rushania G. , BULGAKOVA Irina A. 
Published: January 2019

The detailed characterization of the environmental conditions of sedimentation of the productive formation makes it possible to refine the features of the geological structure. The authors carried out a detailed lithologic-facial analysis of the deposits of the Yu12 productive formation at one of the deposits located in the southeastern part of the West Siberian oil and gas basin. Detailed lithologic-facial schemes were constructed that reflect the spatial distribution of the main permeable bodies, considering the forecast of the distribution of promising reservoir rocks in zones not covered by drilling. The well test results confirm the adopted model of sedimentary facies distribution over the area of the deposit. The proposed conceptual model was used to construct a three-dimensional facial model of the deposit. Thus, a detailed lithologic-facial analysis of the core and forms of the GIS curves showed that deposits of the stack accumulated in coastal-marine sedimentation environments – "marshes" and "watts", repeatedly replacing each other vertically.
Measuring Dairy Farm Efficiency in the Republic of Kazakhstan
Authors: BALKIBAYEVA Aida , AIDYNOV Zein , ORAZBAYEVA Ayagoz , SHEIKO Yuliya , AIKUPESHEVA Dina 
Published: January 2019

Study was conducted in the area of comparative dairy efficiency and finding the most effective farms that can be used by less effective farms and new dairy farms to increase their outputs and use inputs in more productive ways. We used the data of dairy farms for 2015 provided by National Committee on Statistics of Kazakhstan upon our request to perform this research and applied Data Envelope Analysis (DEA). The closest to the efficiency boundary was the dairy farm with a value of 0.66 (milk production 3 573 tons per year with the following top expenses: feed $400K; depreciation $200K and salary $142.424). Based on super-efficiency factors farm No 3 which produced 762,1 tons of milk per year with the cost closest to min mean was found as the most effective one among others. The least efficient was farm No 1 produced the most amounts of milk but with higher than average expenses.
Based on the literature-based review the concept of dairy efficiency was developed, showing the linkage between inputs such as feed, salary, depreciation, energy and others.
Further analysis can show the geographic and climatic similarity or the identity of the management system of reference, distribution of feed and tied inefficient pre-regions. Proceeding from this, it is possible to develop and make management decisions that allow inefficient enterprises to become effective companies
Methods of Sustainable Regulation of Agricultural Enterprises at the Present Stage
Authors: AIMURZINA Baglan , KAMENOVA Mazken , OMAROVA Ainura , BAKYTGUL Ainakanova , AIGUL Kazkenova , NURGUL Shaikenova 
Published: January 2019

This article notes that one of the real sectors of the economy contributing to the development of Kazakhstan is agriculture. In this regard one of the priorities of the economy of the Republic of Kazakhstan is the accelerated sustainable development of agriculture on the basis of tax methods of regulation of agricultural producers. Taxes are one of the most important economic regulators, the basis of financial and credit mechanism of state regulation of economic sectors including agriculture. It is obvious that the success of economic reform in Kazakhstan depends to a large extent on the directions in which the transformation of the tax system of the country will go, how much the tax policy of the state will meet the requirements of the development of socially important sectors of the economy.
The analysis of the structure of tax revenues from the subjects of sustainable development of agriculture of the Republic of Kazakhstan shows the impact of reducing the tax burden on the income of agricultural producers. Proposals for further improvement of tax regulation are given.
A kiégés előfordulása és megelőzési lehetőségei ápolók körében
Authors: Czeglédi Edit , Tandari-Kovács Mariann 
Published: January 2019

Abstract: Within the health care system, nurses face multiple hazards from the aspect of burnout syndrome (emotional exhaustion, depersonalisation, and reduced personal accomplishment) development. Burnout has a negative impact on the health and economic status of individuals. Moreover, burnout diminishes compliance, reduces the quality of care, and it influences the prevalence of medical malpractice and complications. Therefore the identification, prevention and treatment of burnout are of public interest. In this study, we present the occurrence of burnout among Hungarian nurses, and we recommend options to prevent the burnout of nurses, focusing especially on the role and possibilities of psychological counselling. All these provide practical aspects and feasibility in preventing and overcoming burnout. Orv Hetil. 2019; 160(1): 12–19.
Necrotic lower extremities ulcers caused by calciphylaxis in chronic renal failure patient
Authors: Suryawati Nyoman , Saputra Herman 
Published: January 2019

Introduction: Lower extremity ulcers often create diagnostic challenges and influence patient morbidity and mortality. The most common causes are venous insufficiency, arterial insufficiency, and neuropathic. Ulcers associated with systemic condition often face diagnostic and therapeutic challenge. We report a necrotic lower extremity ulcer caused by calciphylaxis in a patient with chronic renal failure. Case: We reported a 48-year-old Javanese woman, complained of painful lower extremities ulcers since 1.5 months ago. The patient had a history of renal failure and hypertension, undergone routine hemodialysis since 13 years ago, and used Continuous Ambulatory Peritoneal Dialysis (CAPD) since one year ago. Dermatology status on dorsum pedis sinister as well as cruris dexter and sinister showed multiple ulcers on livid skin covered by black eschar, accompanied by tenderness. Laboratory results showed anemia (Hb 7.6), hypoalbuminemia (2.7), increased serum urea level (170.4 mg/dl), increased serum creatinine (11.23 mg/dl), increased calcium (10.4 mg/dl), high inorganic phosphorus (8.5 mg/dl) and high parathyroid hormone (2,164). BOF examination showed abdominal calcification, while radiographic examination on cruris dexter et sinister showed soft tissue calcification and osteoporosis. Histopathology result supported the presence of calciphylaxis. The patient was diagnosed with stage V chronic renal failure, hypertension, and calciphylaxis caused by secondary hyperparathyroidism. She was managed by low calcium and phosphate diet, lanthanum, paracetamol, folic acid, adalat oros, captopril and wound debridement. Conclusion: Calciphylaxis is a rare phenomenon of cutaneous necrosis associated with end-stage renal disease. Control of end-stage renal disease may be an important factor for treatment of calciphylaxis and patient with calciphylaxis usually had a poor prognosis.Keywords: necrotic lower extremity ulcer, chronic renal failure, calciphylaxis
Size Effect on the Strength and Deformation Behavior of Glassy Carbon Nanopillars
Authors: Albiez Almut , Schwaiger Ruth 
Published: January 2019

AbstractGlassy carbon nanolattices can exhibit very high strength-to-weight ratios as a consequence of their small size and the material properties of the constituent material. Such nanolattices can be fabricated by pyrolysis of polymeric microlattices. To further elucidate the influence of the mechanical size effect of the constituent material, compression tests of glassy carbon nanopillars with varying sizes were performed. Depending on the specific initial polymer material and the nanopillar size, varying mechanical properties were observed. Small nanopillars exhibited elastic-plastic deformation before failure initiation. Moreover, for smaller nanopillars higher strength values were observed than for larger ones, which might be related to smaller defects and a lower defect concentration in the material.
Nasoethmoidal Intestinal-Type Adenocarcinoma Treated with Cetuximab: Role of Liquid Biopsy and BEAMing in Predicting Response to Anti-Epidermal Growth Factor Receptor Therapy
Authors: Cabezas-Camarero Santiago , de la Orden García Virginia , García-Barberán Vanesa , Mediero-Valeros Beatriz , Subhi-Issa Ahmad Issa , Llovet García Patricia , Bando-Polaino Inmaculada , Merino Menéndez Salomé , Pérez-Segura Pedro , Díaz-Rubio Eduardo 
Published: January 2019

Abstract

Sinonasal intestinal-type adenocarcinomas (SNS-ITAC) are very rare tumors that resemble colorectal cancer in many of their pathological and molecular characteristics. Indeed, in most published series, 10%–14% of SNS-ITAC harbor mutations in KRAS. There is no standard systemic treatment in recurrent or metastatic SNS-ITAC, and there is no evidence of the use of any targeted agent in this entity. We present the case of a recurrent nasoethmoidal ITAC informed as RAS and BRAF wild-type by standard real-time polymerase chain reaction methods and treated with first-line cetuximab and irinotecan without response. Circulating tumor cells coupled to highly sensitive DNA analyses unveiled a mutation in KRAS exon 2 codon 12. Subsequent studies in the primary tumor using BEAMing detected a mutation in the same codon, confirming the KRAS mutated status of the tumor, and possibly explaining the absence of treatment response. This case exemplifies how liquid biopsy can aid in the correct and real-time molecular characterization of tumors even in a rare nonmetastatic cancer of the head and neck.

Key Points
Sinonasal intestinal type adenocarcinomas (SNS-ITAC) are rare tumors that commonly develop after a prolonged exposure to organic dusts (wood, leather, etc.), and that resemble colorectal cancer in some of their morphological and molecular characteristics. KRAS mutations have been described in 10%–14% in most series. However, its predictive value for guiding treatment decisions with targeted therapies (i.e., anti-epidermal growth factor receptor [EGFR] therapy) has not been defined. The first case of an SNS-ITAC treated with anti-EGFR therapy (cetuximab) is reported. Analysis of DNA from circulating tumor cells (CTCs) unveiled a mutation in KRAS not detected by standard methods in the primary tumor. However, RAS analysis using BEAMing detected a mutation in the primary tumor in the same codon of KRAS originally detected in CTCs, altogether possibly explaining the lack of treatment response. Liquid biopsy may allow for an accurate molecular diagnosis in rare, organ-confined tumors where few therapeutic options exist. Highly sensitive molecular diagnostics may aid in better characterizing rare entities harboring potentially druggable targets.
Phase II Study of Weekly Paclitaxel with Trastuzumab and Pertuzumab in Patients with Human Epidermal Growth Receptor 2 Overexpressing Metastatic Breast Cancer: 5-Year Follow-up
Authors: Wang Rui , Smyth Lillian M. , Iyengar Neil , Chandarlapaty Sarat , Modi Shanu , Jochelson Maxine , Patil Sujata , Norton Larry , Hudis Clifford A. , Dang Chau T. 
Published: January 2019

Abstract

Background
Favorable progression-free survival (PFS) and overall survival (OS) results were previously reported on a phase II trial of patients with human epidermal growth receptor 2 (HER2)-positive metastatic breast cancer (MBC), treated with weekly paclitaxel in combination with trastuzumab and pertuzumab in the first- and second-line setting, with a median follow-up of 33 months. Here, we report updated PFS and OS results with more than 2 years of additional follow-up.

Materials and Methods
In this phase II study, adult patients with HER2-positive MBC who received no or one prior therapy received intravenous paclitaxel (80 mg/m2 weekly) with trastuzumab (8 mg/kg loading dose followed by 6 mg/kg every 3 weeks) and pertuzumab (840 mg loading dose followed by 420 mg every 3 weeks), administered in 21-day cycles. Primary endpoint was 6-month PFS, and secondary endpoints included median PFS and OS.

Results
From January 2011 to December 2013, 69 patients were enrolled: 51 (74%) and 18 (26%) were treated in first- and second-line metastatic settings, respectively. As of August 21, 2017, the median follow-up was 59 months (range, 20–75 months; 67 [97%] patients were evaluable for efficacy). The 6-month PFS was 86% (95% confidence interval [CI] 0.76–0.93). The median PFS was 24.2 months (95% CI 17–35) for the overall population; it was 25.7 months (95% CI 17.0 to not reached) and 20.1 months (95% CI 8.5–33.0) for patients with no and one prior treatment, respectively. The median OS was not reached for the overall group; it was not reached and 39.7 months (95% CI 32.9–66.7) for patients with no and one prior treatment, respectively. Treatment was well tolerated with no additional safety concerns.

Conclusion
With a longer follow-up of almost 5 years, combination of weekly paclitaxel, trastuzumab, and pertuzumab remains effective with a favorable median PFS and a median OS not reached.
Nakşibendîlik’in Anadolu’da Ortaya Çıkışının Belgesi: Şeyh Hâce İshak er-Rumî Vakfiyesi / A Document for Naqshibandi Emergence in Anatolia: The Waqfiyya of Sheikh Hâce İshak er-Rumî
Authors: DEMİRTAŞ Hasan 
Published: January 2019

Nakşibendîlik, 14. yüzyılda Orta Asya’da, Bahâeddin Nakşibend tarafından kurulduğu kabul edilen tasavvuf akımıdır. Bu tasavvuf hareketi, zamanla Hindistan, Kafkaslar, Orta Doğu, Anadolu ve akabinde Balkanlar olmak üzere geniş bir sahaya yayılarak günümüze kadar ulaşmıştır. Özellikle 15. ve 16. yüzyıllardan itibaren İslam dünyasının fikrî yapısının şekillenmesinde büyük bir etkiye sahip olan Nakşibendîlik’in Anadolu’ya girişinin ve yaygınlaşmasının Osmanlı döneminde 15. yüzyılın ikinci yarısında Simavlı Molla Abdullah-ı İlahi vasıtasıyla olduğu ilim çevrelerince kabul görmektedir. Kimi çalışmalarda ise Nakşibendîlik’in Anadolu’ya girişi Ankara Savaşı sırasında Emir Timur’un ordusunda bulunan Nakşî şeyhleri ile irtibatlandırıldığı görülmekte ve Nakşibendîlik’in Anadolu’da ilk tekkesinin Bedreddin Mahmud Çelebi tarafından 1404-1405 yılında Amasya'da kurulduğu öne sürülmektedir. Bu makalede, Nakşibendîlik tarihi bakımından önemli muhtevaya sahip olduğunu düşündüğümüz 1381 tarihli Şeyh Hâce İshak er-Rumî vakfiyesi konu edilmektedir. İki bölümden oluşan makalenin ilk bölümünde Saruhanoğluları Beyliği dönemine ait olup daha önce neşredilmemiş olan Şeyh Hâce İshak er-Rumî vakfiyesi diplomatik açıdan değerlendirmeye tabi tutulacaktır. İkinci bölümde ise, makale sınırları da göz önünde bulundurularak, mevcut literatürde Nakşibendîlik tarihi açısından genel kabul halini almış olan Nakşibendîlik’in isimlendirilmesi, Anadolu’da ortaya çıkışı ve kurumsallaşması gibi üç temel konu hakkında Şeyh İshak er-Rumî vakfiyesinin sunmuş olduğu veriler ışığında yeni tespitler ortaya konulacaktır.
Adıyaman Şeyh Abdurrahman Erzincanî Zaviyesi Vakfı / Waqf of Adıyaman Sheikh Abdurrahman Erzincani Zawiyah
Authors: TURGUT Bahattin 
Published: January 2019

Şeyh Abdurrahman Erzincanî, zaviyesini 15. yüzyılda Adıyaman’ın Zey köyünde kurmuştur. Vakfın temelini hükümdarlar ve hayırseverler tarafından zaviyeye bağışlanan araziler oluşturmuştur. Şeyh Abdurrahman Erzincanî Zaviyesi Vakfı, soya dayalı bir aile vakfı olduğundan vakfın ve zaviyenin yöneticiliği ile ilgili görevlerden şeyhlik, mütevellilik, zaviyedarlık ve mezraadarlık Osmanlı’nın sonuna kadar Şeyh Abdurrahman Erzincanî evlatlarınca yürütülmüştür. İki camisi ile birlikte zaviyesi, sıbyan mektebi, medresesi ve aşevi ile Şeyh Abdurrahman Erzincanî Zaviyesi vakfı, Adıyaman ve çevresinde topluma yönelik önemli hizmetler gerçekleştirmiştir. Vakfın mülklerinden elde edilen gelir, vakfa bağlı hayrî kurumların idaresine, idamesine, masraflarına ve personel maaşlarına harcanmıştır. Şeyh Abdurrahman Erzincanî Zaviyesi vakfı, kurulmasından Osmanlı Devleti’nin sonuna kadar topluma hizmet veren, devlete destek olan ve devletten destek gören bir sivil toplum kuruluşu olmuştur.