bluuebunny/crossref_metadata_2025_split huggingface dataset:
Middle Wisconsinan marine shells near Repulse Bay, Nunavut, Canada: implications for Marine Isotope Stage 3 ice‐free conditions and Laurentide Ice Sheet dynamics in north‐west Hudson Bay
Authors: McMartin Isabelle , Campbell Janet E. , Dredge Lynda A. 
Published: January 2019

ABSTRACTEvidence suggesting a reduction of the Laurentide Ice Sheet (LIS) during Marine Isotope Stage 3 (MIS 3) is widespread but the boundaries of the ice sheet and the timing of minimum ice extent are still poorly constrained. Radiocarbon dating of glacially transported marine mollusks in Rae Isthmus ice stream till south of Repulse Bay, Nunavut, Canada, provides new evidence for MIS 3 deglaciation in the north‐west part of Hudson Bay. Middle Wisconsinan finite 14C ages varying between 31.7 and 39.2k 14C a BP (∼35.0 and 43.7k cal a) indicate a marine event(s) for a minimum of ∼8.7k cal years. Our findings suggest ice‐free conditions in the ice stream source area in proto‐Roes Welcome Sound, and therefore significant glacial recession of the LIS margin during the Middle Wisconsinan, much farther in the interior of the ice sheet than previously known. The marine incursion possibly occurred because of a calving bay developed from the north in the Gulf of Boothia − Committee Bay area following the recession and collapse of the ice stream. After the MIS 3 marine episode(s), the topographically controlled ice stream stemming from the eastern end of the Keewatin Ice Divide was re‐activated, and maintained until deglaciation.
Confronting uncertainty: Contributions of the wildlife profession to the broader scientific community
Authors: Nichols James D. 
Published: January 2019

ABSTRACTMost wildlife professionals are engaged in 1 or both of 2 basic endeavors: science and management. These endeavors are a focus of many other disciplines, leading to widespread sharing of general methodologies. Wildlife professionals have appropriately borrowed and assimilated many methods developed primarily in other disciplines but have also led the development of one class of quantitative methods, those that confront and incorporate uncertainty. Uncertainty arises in counts of focal entities, for which wildlife professionals have developed effective methods to deal with the common problems of nondetection and misclassification. These methods have been borrowed by disciplines as varied as paleobiology, medicine, human epidemiology, industrial quality control, military target acquisition, remote sensing, and human census. Uncertainty also arises in the modeling of those counts, specifically the observation and ecological processes that generated them. Wildlife professionals recognized the fundamental importance of model selection and rapidly assimilated methods for selecting the most appropriate model for a given data set. These methods for dealing with uncertainty inherent to counting and modeling are critical to the conduct of science and management. Wildlife professionals have developed additional methods for incorporating uncertainty in the accumulation of knowledge and the development of optimal decisions in an environment of learning. In some cases, professionals in other disciplines are using methods developed and popularized in the wildlife profession, but there is much potential for greater use. In this essay, I describe these areas of wildlife leadership, document their assimilation by other disciplines, and emphasize the potential for more interdisciplinary use of these methods. © 2019 The Wildlife Society.
Determining effectiveness of EBM education in otolaryngology residents using modified fresno test
Authors: Bastaninejad Shahin , Soltani Akbar , Dabiran Soheila , Amali Amin , Adil Suzan , Borghei Pedram , Mazarei Alireza 
Published: January 2019

ObjectiveTo determine the effectiveness of education in evidence‐based medicine (EBM) on the knowledge, competency, and skills of otolaryngology residents of Tehran University of Medical Sciences (TUMS) at Amir‐Alam and Imam Khomeini Hospitals.MethodsIn a quasi‐experimental (before‐and‐after) study, all ear, nose, and throat residents of TUMS (n = 41) entered the study. The residents underwent the modified Fresno test. Then, two EBM workshops with a similar content were held on 2 separate days in each hospital, with each session lasting 6 hours. The learned material was practiced in weekly journal clubs. Six months after the workshop, the modified Fresno test was applied again, and the results were analyzed.ResultsA significant improvement in the modified Fresno test score was observed. The mean score of the modified Fresno test was 57.43 ± 22.07 before the workshop and 79.26 ± 22.48 after the workshop (P < 0.001).ConclusionThe results of the study show that EBM education and practice of the learned materials in journal clubs can improve the knowledge and skills of residents.Further research with larger samples is needed to improve the precision of our findings and to increase confidence in the results.Level of Evidence2Laryngoscope, 129:2291–2294, 2019
Tracheo‐innominate fistula in children: A systematic review of literature
Authors: Lee Daniel J. , Yang Weining , Propst Evan J. , Rosenblatt Steven D. , Hseu Anne , Wolter Nikolaus E. 
Published: January 2019

ObjectiveTracheo‐innominate fistula (TIF) is a rare but fatal complication of tracheotomy. To date, there is a paucity of literature regarding pediatric TIFs. The objectives of this study were to conduct a systematic review of literature on pediatric TIF following tracheotomy and describe three demonstrative cases from our institutional experience.MethodsWe conducted a systematic review using MEDLINE, Embase, Cochrane Database of Systematic Reviews, Web of Science, and CINAHL. All studies with pediatric patients (under 18 years of age) who developed TIF following tracheotomy were included.ResultsFifty‐four publications met inclusion criteria, reporting on 77 cases. The most common indication for tracheotomy was prolonged intubation and the need for ventilatory support (38.6%), with neurological comorbidities being the most common indication (72.7%). The mean time to TIF was 395.7 days (95% confidence interval, 225.9–565.5). Fifty‐four patients (70.1%) presented with massive hemorrhage, whereas 18 patients (23.3%) presented with a sentinel bleeding event. The most common diagnostic interventions were computed tomography scan with or without contrast and bronchoscopy (55.8%). A substantial number of patients did not have any investigations (41.6%). Surgical management occurred in 70.1% of patients. Mortality was 38.6% in reported cases with variable follow‐up periods.ConclusionTIF may occur in long‐term tracheostomy‐dependent children, contrary to the conventionally described 3‐week postoperative period. The mortality may not be as high as previously reported with timely intervention. Our results are limited by inherent risks of bias. Further research including well‐designed cohort studies are needed to guide an evidence‐based approach to TIF.Level of EvidenceNA Laryngoscope, 130:217–224, 2020
Evolution of the butterfly graft technique: 15‐year review of 500 cases with expanding indications
Authors: Howard Brittany E. , Madison Clark J. 
Published: January 2019

Objectives/HypothesisTo describe the evolution of the butterfly graft technique for the treatment of nasal valve compromise, with specific attention to technical developments allowing for expanded indications. To review the impact on patient‐reported outcomes of nasal airway function and nasal aesthetics.Study DesignRetrospective chart review.MethodsA review of a single surgeon's patients at a private practice and tertiary care center undergoing surgical correction for nasal valve compromise using the butterfly graft technique between July 2002 and April 2017. Data collected included etiology of nasal valve compromise, additional procedures performed, complications, and functional and aesthetic patient‐reported outcomes.ResultsOver the study period, 512 patients underwent surgery to correct nasal valve compromise utilizing the butterfly graft technique. The overall patient‐reported relief of nasal obstructive symptoms was complete in 87%, improved but not completely relieved in 10%, and not improved in 4%. No patients reported a worsening in their nasal obstructive symptoms. The overall patient‐reported change in nasal appearance was improved 53%, the same 32%, worse in 15%. The patients in the latter half of the study tended to report better aesthetic results.ConclusionsThe results of this study suggest that the surgical technique for the butterfly graft evolved over time and allowed for improved aesthetic outcomes, without reduction in the efficacy in correction of nasal valve compromise. The evolution in technique allowed for expansion of the indications for the butterfly graft while maintaining the favorable patient‐reported aesthetic and functional results.Level of Evidence4Laryngoscope, 129:S1‐S10, 2019
Nonsquamous cell laryngeal cancers: Incidence, demographics, care patterns, and effect of surgery
Authors: Torabi Sina J. , Cheraghlou Shayan , Kasle David A. , Savoca Emily L. , Judson Benjamin L. 
Published: January 2019

ObjectivesTo analyze the incidence and clinical profile of nonsquamous cell (non‐SCC) laryngeal carcinomas and to analyze the effect of surgery on survival.Study DesignA retrospective analysis of the National Cancer Database (2004–2014).MethodsAdult patients with non‐SCC laryngeal cancers were divided into six major histological subtypes. A descriptive clinical profile was obtained for non‐SCC patients, and multivariate regressions were performed to analyze the effect of surgery on survival within the non‐SCC cohort.ResultsWe identified 878 cases of non‐SCC laryngeal cancers, representing 1.02% of all malignant laryngeal cancers. Neuroendocrine tumors and bone/cartilage sarcomas made up the largest groups (37.02% and 32.35%, respectively). Metastasis (M) was higher in neuroendocrine tumors, representing 19.1% of those with known clinical M stages. Of those treated, the majority of patients with bone/cartilage sarcomas (80.9%) and minor salivary gland tumors (82.6%) received surgery as part of their treatment. Survival varied significantly based upon histology, with bone/cartilage sarcomas having the highest 5‐year survival at 90.4%, and neuroendocrine tumors exhibiting the poorest 5‐year survival at 25.7%. Multivariate analyses found surgery to be significantly associated with improved survival (hazard ratio: 0.679; 95% confidence interval: 0.472–0.976; P = 0.036). The specific surgical method (i.e., local excision vs. partial vs. total laryngectomy) did not have any effect on survival.ConclusionApproximately 1% of all malignant laryngeal cancers are non‐SCC in origin. At presentation, neuroendocrine tumors have the highest rate of distant metastasis and have the worst prognosis of the non‐SCC cancers. Most non‐SCC patients received surgery as part of their treatment regimen.Level of EvidenceNA. Laryngoscope, 129:2496–2505, 2019
Carrier‐Envelope‐Offset Frequency Stable 100 W‐Level Femtosecond Thin‐Disk Oscillator
Authors: Gröbmeyer Sebastian , Brons Jonathan , Seidel Marcus , Pronin Oleg 
Published: January 2019

AbstractIn this paper, the carrier‐envelope‐offset (CEO) frequency stabilization of a Kerr‐lens mode‐locked femtosecond oscillator with average power 105 W is presented. Intra‐cavity Kerr lensing is realized in a quartz crystal that simultaneously serves as an acousto‐optic loss modulator. This novel method results in a CEO frequency stable laser with high average power and a residual in‐loop phase noise below 90 mrad. Furthermore, an all‐solid‐state bulk broadening stage is presented. The compressed, CEO frequency‐stabilized output has a peak power exceeding 67 MW at a pulse duration of 40 fs and a repetition rate of 15.6 MHz. The intra‐cavity peak power of the CEO frequency‐stabilized oscillator is around 200 MW. These results pave the way toward compact, transportable all‐solid‐state drivers with high repetition rates for deep UV and XUV frequency combs and other nonlinear processes.
Recent Trends on Transparent Colorless Polyimides with Balanced Thermal and Optical Properties: Design and Synthesis
Authors: Tapaswi Pradip Kumar , Ha Chang‐Sik 
Published: January 2019

AbstractRecently, colorless and transparent plastic substrates with high glass transition temperature and suitable thermo‐mechanical properties are in high demand in optoelectronic device industries, due to their various optical applications. Colorless polyimides (CPIs) exhibit both high thermo‐mechanical stability as well as high transparency that are suitable for optoelectronic applications. The most recent (2010–2018) developments on CPIs, in terms of design and synthesis of new monomers and their effects on the thermo‐optical properties of the obtained CPIs, are reviewed in this article.
RNA‐Seq detects a SAMD12‐EXT1 fusion transcript and leads to the discovery of an EXT1 deletion in a child with multiple osteochondromas
Authors: Oliver Gavin R. , Blackburn Patrick R. , Ellingson Marissa S. , Conboy Erin , Pinto e Vairo Filippo , Webley Matthew , Thorland Erik , Ferber Matthew , Van Hul Els , van der Werf Ilse M. , Wuyts Wim , Babovic‐Vuksanovic Dusica , Klee Eric W. 
Published: January 2019

AbstractBackgroundWe describe a patient presenting with pachygyria, epilepsy, developmental delay, short stature, failure to thrive, facial dysmorphisms, and multiple osteochondromas.MethodsThe patient underwent extensive genetic testing and analysis in an attempt to diagnose the cause of his condition. Clinical testing included metaphase karyotyping, array comparative genomic hybridization, direct sequencing and multiplex ligation‐dependent probe amplification and trio‐based exome sequencing. Subsequently, research‐based whole transcriptome sequencing was conducted to determine whether it might shed light on the undiagnosed phenotype.ResultsClinical exome sequencing of patient and parent samples revealed a maternally inherited splice‐site variant in the doublecortin (DCX) gene that was classified as likely pathogenic and diagnostic of the patient's neurological phenotype. Clinical array comparative genome hybridization analysis revealed a 16p13.3 deletion that could not be linked to the patient phenotype based on affected genes. Further clinical testing to determine the cause of the patient's multiple osteochondromas was unrevealing despite extensive profiling of the most likely causative genes, EXT1 and EXT2, including mutation screening by direct sequence analysis and multiplex ligation‐dependent probe amplification. Whole transcriptome sequencing identified a SAMD12‐EXT1 fusion transcript that could have resulted from a chromosomal deletion, leading to the loss of EXT1 function. Re‐review of the clinical array comparative genomic hybridization results indicated a possible unreported mosaic deletion affecting the SAMD12 and EXT1 genes that corresponded precisely to the introns predicted to be affected by a fusion‐causing deletion. The existence of the mosaic deletion was subsequently confirmed clinically by an increased density copy number array and orthogonal methodologiesConclusionsWhile mosaic mutations and deletions of EXT1 and EXT2 have been reported in the context of multiple osteochondromas, to our knowledge, this is the first time that transcriptomics technologies have been used to diagnose a patient via fusion transcript analysis in the congenital disease setting.
Combined Ligand and Fragment‐based Drug Design of Selective Histone Deacetylase – 6 Inhibitors
Authors: Ruzic Dusan , Petkovic Milos , Agbaba Danica , Ganesan A. , Nikolic Katarina 
Published: January 2019

AbstractHistone deacetylase 6 (HDAC6) is unique hydrolase within HDAC family, having pleiotropic deacetylase activity against α‐tubulin, cortactin and dynein. Comprehensively, HDAC6 controls cell motility, apoptosis and protein folding, whereas alterations in its structure and function are related to the pathogenesis of cancer, neurodegeneration and inflammation. To define structural motifs which guide HDAC6 selectivity, we developed and compared three‐dimensional Quantitative Structure‐Activity Relationship (3D‐QSAR) models for HDAC1 and HDAC6 inhibitors. The reduction of the bias in conformer generation was supported by virtual docking study by using crystal structures of human HDAC1 and HDAC6 isoforms. Following these findings, the combined ligand‐based and fragment‐based drug design methodologies were used in the design of selective HDAC6 inhibitors. Group of the most promising novel ligands was selected based on the predicted HDAC6 selectivity, pharmacokinetic profile, synthetic tractability, and in silico cytotoxicity against the wide range of human cancer cell lines.
Optimized neural network using beetle antennae search for predicting the unconfined compressive strength of jet grouting coalcretes
Authors: Sun Yuantian , Zhang Junfei , Li Guichen , Wang Yuhang , Sun Junbo , Jiang Chao 
Published: January 2019

SummaryThis investigation studied the coalcrete, a new supporting material produced by jet grouting (JG) for supporting surrounding coal seams. For support design, the unconfined compressive strength (UCS) of the coalcrete is an essential parameter to evaluate the jet grouting effect in coal mines. In this study, an intelligent technique was proposed for predicting the UCS of the coalcrete by combining back propagation neural network (BPNN) and beetle antennae search (BAS). The architecture of BPNN was first tuned by BAS, and then, the optimized BPNN‐BAS model was subsequently used for nonlinear relationship modeling. Several crucial influencing variables including water‐cement ratio, coal‐grout ratio, and curing time were selected as the inputs. By combining these variables, 360 coalcrete samples were prepared in a controlled laboratory environment and tested for establishing the dataset. The results demonstrate that BAS can tune the BPNN architecture more efficiently compared with random selection. Moreover, in comparison with multiple regression (MLR) and logistic regression (LR), and support vector machine (SVM), the optimized BPNN‐BAS model is more reliable and accurate for predicting coalcrete strength. Sensitivity analysis (SA) was used to obtain the variable importance, and the results demonstrate that curing time affects the UCS of the coalcrete most strongly, followed by water‐cement ratio and coal‐grout ratio. The success of this study provides an accurate and brief approach to coalcrete strength prediction.
Micromechanical analysis of sand production
Authors: Garolera Daniel , Carol Ignacio , Papanastasiou Panos 
Published: January 2019

SummaryWe present a micromechanical approach based on zero‐thickness interface elements for modelling advanced localization and cracking states of cemented granular materials, such as reservoir sandstones. The proposed methodology is capable of reproducing the complex behaviour of intergranular and intragranular localization, cracking, and fracturing of rock formation that leads to sanding in hydrocarbon production. The model is calibrated at the macroscale, using only a few physical parameters, by reproducing the typical behaviour of compression element tests. The model exhibits clear transition behaviour from brittle dilatant to ductile compactant behaviour with increasing confining stress. The methodology is implemented for sand production prediction analysis based on the simulation of 2D micromechanical models of hollow cylinder cross sections. The obtained results are compared well with published experimental data from hollow cylinder tests characterized by strong scale effect in the range of small perforations.
Effective Counter‐Terrorism: Rockets, Iron Dome, and the Israeli Housing Market
Authors: Elster Yael , Zussman Asaf , Zussman Noam 
Published: January 2019

AbstractHow effective is counter‐terrorism and what are the underlying mechanisms? Relying on a unique experiment and detailed micro data from Israel, we show that the deployment of the Iron Dome anti‐rocket system mitigated the negative effect of rocket attacks on house prices and lowered the price premium associated with in‐house shelters. Analysis of surveys and data on purchases of anti‐anxiety drugs yields evidence consistent with a psychological mechanism: by reducing the negative effects on daily routine, subjective well‐being, and psychological distress, Iron Dome lowered the disamenity associated with living under the shadow of the rocket threat.
Integration of microbiology, molecular pathology, and epidemiology: a new paradigm to explore the pathogenesis of microbiome‐driven neoplasms
Authors: Hamada Tsuyoshi , Nowak Jonathan A , Milner Danny A , Song Mingyang , Ogino Shuji 
Published: January 2019

AbstractMolecular pathological epidemiology (MPE) is an integrative transdisciplinary field that addresses heterogeneous effects of exogenous and endogenous factors (collectively termed ‘exposures’), including microorganisms, on disease occurrence and consequences,
utilising molecular pathological signatures of the disease. In parallel with the paradigm of precision medicine, findings from MPE research can provide aetiological insights into tailored strategies of disease prevention and treatment. Due to the availability of molecular pathological tests on tumours, the MPE approach has been utilised predominantly in research on cancers including breast, lung, prostate, and colorectal carcinomas. Mounting evidence indicates that the microbiome (inclusive of viruses, bacteria, fungi, and parasites) plays an important role in a variety of human diseases including neoplasms. An alteration of the microbiome may be not only a cause of neoplasia but also an informative biomarker that indicates or mediates the association of an epidemiological exposure with health conditions and outcomes. To adequately educate and train investigators in this emerging area, we herein propose the integration of microbiology into the MPE model (termed ‘microbiology‐MPE’), which could improve our understanding of the complex interactions of environment, tumour cells, the immune system, and microbes in the tumour microenvironment during the carcinogenic process. Using this approach, we can examine how lifestyle factors, dietary patterns, medications, environmental exposures, and germline genetics influence cancer development and progression through impacting the microbial communities in the human body. Further integration of other disciplines (e.g. pharmacology, immunology, nutrition) into microbiology‐MPE would expand this developing research frontier. With the advent of high‐throughput next‐generation sequencing technologies, researchers now have increasing access to large‐scale metagenomics as well as other omics data (e.g. genomics, epigenomics, proteomics, and metabolomics) in population‐based research. The integrative field of microbiology‐MPE will open new opportunities for personalised medicine and public health. Copyright © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.