bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing 4‐mm dental implants to longer implants placed in augmented bones in the atrophic posterior mandibles: One‐year results of a randomized controlled trial
Authors: Rokn Amir Reza , Monzavi Abbas , Panjnoush Mehrdad , Hashemi Hamid Mahmood , Kharazifard Mohammad Javad , Bitaraf Tahereh 
Published: October 2018

AbstractBackgroundShort implants have been proposed as an alternative for the rehabilitation of atrophic edentulous areas.PurposeTo evaluate the efficacy of 4‐mm implants vs longer implants in the atrophic posterior mandibles.Materials and MethodsEleven patients with bilateral atrophic mandibles were rehabilitated with two to four 4‐mm implants and 10 or 8‐mm long implants in augmented bone using Guided Bone Regeneration procedure. One side of the mandibles was randomly allocated to vertical augmentation with mixed autogenous bone and allograft. Implants were placed in both sides of the mandible after 6 months, and loaded after another 2 months. Subsequently, implant and prosthesis failures, marginal bone levels changes, and any complication were evaluated after 1‐year follow‐up.ResultsIn this study, one patient dropped out and no failures occurred. However, 4‐mm implants loss of 0.30 ± 0.34 mm peri‐implant marginal bone and long implants loss of 0.47 ± 0.54 mm marginal bone were observed after 1‐year of follow‐up. The difference between the two groups was not statistically significant (difference = −0.16 ± 0.68 mm; P = 0.46). Eight complications occurred in five augmented sites of the patients, and no complication was found to occur in the short implants sites.ConclusionsOne‐year after loading, 4‐mm implants had similar outcomes as long implants in augmented bone. Therefore, short implants might be a feasible treatment in atrophic mandibles.
Dental Implant Quality Register—A possible tool to further improve implant treatment and outcome
Authors: Klinge Björn , Lundström Mats , Rosén Måns , Bertl Kristina , Klinge Anna , Stavropoulos Andreas 
Published: October 2018

AbstractThe Board ofEAO(European Association for Osseointegration) has discussed an initiative to explore the conditions to establish a Dental Implant Register. It was suggested to bring this issue to theEAOConsensus Conference 2018 for a discussion and to possibly propose relevant and manageable parameters. This article presents some select examples from quality registers in the medical field. Based on the experience of established registers, essentially in the medical field, factors considered to be of importance, if and when establishing a Dental Implant Register are introduced and discussed.
Drugs and diseases: Summary and consensus statements of group 1. The 5thEAO Consensus Conference 2018
Authors: Schliephake Henning , Sicilia Alberto , Nawas Bilal Al , Donos Nikos , Gruber Reinhard , Jepsen Søren , Milinkovic Iva , Mombelli Andrea , Navarro Jose Manuel , Quirynen Marc , Rocchietta Isabella , Schiødt Morten , Schou Søren , Stähli Alexandra , Stavropoulos Andreas , Sánchez Suárez Luis Miguel 
Published: October 2018

AbstractObjectivesThe task of this working group was to update the knowledge about the use of drugs and biologicals affecting healing of soft tissue and bone during implant treatment or procedures associated with it. Moreover, the impact of titanium particles and biocorrosion on complications and implant survival has been analysed.Materials and MethodsThe literature in the areas of interest (platelet concentrates, antiresorptive drugs as well as implant–host interaction) was screened using systematic reviews for the former two areas, whereas a narrative critical review was performed for the latter topic. Two manuscripts on platelet concentrates, one manuscript on antiresorptive drugs and one manuscript on the effects of biocorrosion, were presented for group analysis with subsequent discussion in the plenum and final consensus approval.ResultsResults and conclusions of the individual reviews of the three topics are presented in the respective papers. Conclusions of the group on strengths and weaknesses of available evidence as well as consensus statements and directions for further research are provided in this study.The following papers were subject to group discussions and formed the basis for the consensus statements:

Stähli A, Strauss FJ, Gruber R. () The use of platelet‐rich‐plasma to enhance the outcomes of implant‐related therapies: a systematic review

Strauss FJ, Stähli A, Gruber R. (2018) The use of platelet‐rich‐fibrin to enhance the outcomes of implant‐related therapies: a systematic review

Mombelli A, Hashim D, Cionca N. () What is the impact of titanium particles and bio‐corrosion on implant survival and complications? A critical review

Stavropoulos A, Bertl K, Pietschmann P, Pandis N, Morten Schiødt, Klinge B. () The effect of antiresorptive drugs on implant therapy: a systematic review.
Biological aspects: Summary and consensus statements of group 2. The 5th EAO Consensus Conference 2018
Authors: Sanz Mariano , Klinge Bjorn , Alcoforado Gil , Bienz Stefan P. , Cosyn Jan , De Bruyn Hugo , Derks Jan , Figuero Elena , Gurzawska Katarzyna , Heitz‐Mayfield Lisa , Jung Ronald E. , Ornekol Turker , Salgado Alberto 
Published: October 2018

AbstractObjectivesThis publication reports the EAO Workshop group‐2 discussions and consensus statements which provided the scientific evidence on the influence of biological parameters on implant‐related clinical outcomes.Material and methodsThe first publication was a systematic review on the biological effects of abutment material on the stability of peri‐implant marginal bone levels and the second, a critical narrative review on how peri‐implant diagnostic parameters correspond with long‐term implant survival and success. The group evaluated the content of both publications, made corrections and recommendations to the authors and agreed on the consensus statements, clinical recommendations and recommendations for future research, which are described in this consensus report.ResultsTested abutment materials can be considered appropriate for clinical use according to the observation period studied (mean 3.5 years). Mean peri‐implant bone loss and mean probing pocket depths are not adequate outcomes to study the prevalence of peri‐implantitis, while the reporting of frequency distributions is considered more appropriate.ConclusionsTitanium is currently considered the standard of care as abutment material, although other materials may be more suitable for aesthetic locations. Peri‐implantitis should be diagnosed through composite evaluations of peri‐implant tissue inflammation and assessment of marginal bone loss with different thresholds.
The use of platelet‐rich fibrin to enhance the outcomes of implant therapy: A systematic review
Authors: Strauss Franz Josef , Stähli Alexandra , Gruber Reinhard 
Published: October 2018

AbstractObjectiveTo assess the impact of platelet‐rich fibrin (PRF) on implant dentistry. The primary focused question was as follows: What are the clinical, histological, and radiographic outcomes of PRF administration for bone regeneration and implant therapy?MethodA systematic literature search comprised three databases: MEDLINE, EMBASE, and Cochrane followed by a hand search of relevant scientific journals. Human studies using PRF for bone regeneration and implant therapy were considered and articles published up to December 31, 2017 were included. Eligible studies were selected based on the inclusion criteria. Randomized controlled trials (RCT) and controlled clinical trials (CCT) were included.ResultsIn total, 5,963 titles were identified with the search terms and by hand search. A total of 12 randomized controlled trials (RCT) met the inclusion criteria and were chosen for data extraction. Included studies focused on alveolar ridge preservation after tooth extraction, osseointegration process, soft tissue management, bone augmentation, bone regeneration after sinus floor elevation and surgical peri‐implantitis treatment. Overall, the risk of bias was moderate or unclear. Nine studies showed superior outcomes for PRF for any of the evaluated variables, such as ridge dimension, bone regeneration, osseointegration process, soft tissue healing. Three studies failed to show any beneficial effects of PRF. No meta‐analysis could be performed due to the heterogeneity of study designs.ConclusionsThere is moderate evidence supporting the clinical benefit of PRF on ridge preservation and in the early phase of osseointegration. It remains unclear whether PRF can reduce pain and improve soft tissue healing. More research support is necessary to comment on the role of PRF to improve other implant therapy outcomes.
Frequency of infraposition and missing contact points in implant‐supported restorations within natural dentitions over time: A systematic review with meta‐analysis
Authors: Papageorgiou Spyridon N. , Eliades Theodore , Hämmerle Christoph H.F. 
Published: October 2018

AbstractObjectivesThe aim of this systematic review was to assess clinical evidence on adverse effects of osseointegrated implants placed among natural teeth of a residual dentition.MethodsSeven databases were searched without restrictions up to January 2018 for clinical studies on implant infraposition (IIP) or proximal contact point (PCP) loss to the adjacent teeth. After duplicate selection, data extraction, and risk of bias assessment according to the Cochrane guidelines, random‐effects meta‐analyses of odds ratios (OR) or mean differences (MD) and their 95% confidence intervals (CI) were performed, followed by meta‐regression and sensitivity analyses.ResultsA total of 27 nonrandomized studies with 1,572 patients (mean age 42.2 years/51.2% female) followed up to 18.5 years after implant placement were included. The pooled %prevalence of IIP was 50.5% (nine studies; 95% CI = 26.3–74.5%), and the pooled IIP extent was 0.58 mm (six studies; 95% CI = 0.33–0.83 mm), while IIP > 1 mm was seen for 20.8% of placed implants (five studies; 95% CI = 8.3–37.1%), and male patients were less prone to IIP than female patients (three studies; OR = 0.30; 95% CI = 0.10–0.88; p = 0.03). The pooled %prevalence of PCP loss was 46.3% (nine studies; 95% CI = 32.3–60.6%), with increase through observation time (two studies; OR = 1.09; 95% CI = 1.03–1.16; p = 0.004) and predilection for mesial PCPs (five studies; OR = 2.25; 95% CI = 1.06–4.77; p = 0.03). However, the quality of evidence was very low due to bias.ConclusionsPatients and doctors need to be aware that long‐term adverse effects of dental implants among natural teeth can be observed in terms of IIP and PCP loss to the adjacent teeth.
Is the use of digital technologies for the fabrication of implant‐supported reconstructions more efficient and/or more effective than conventional techniques: A systematic review
Authors: Mühlemann Sven , Kraus Riccardo D. , Hämmerle Christoph H. F. , Thoma Daniel S. 
Published: October 2018

AbstractObjectiveTo identify clinical studies evaluating efficiency and/or effectiveness of digital technologies as compared to conventional manufacturing procedures for the fabrication of implant‐supported reconstructions.Materials and MethodsA systematic search from 1990 through July 2017 was performed using the online databases Medline, Embase, and Cochrane‐Central‐Register‐of‐Controlled‐Trials. Literature on efficiency and/or effectiveness during the impression session, the manufacturing process, and the delivery session were included.ResultsIn total, 12 clinical studies were included. No meta‐analysis was performed due to a large heterogeneity of the study protocols. Nine publications reported on posterior single implant crowns (SIC) and three on full‐arch reconstructions. Mean impression time with intraoral scanners ranged between 6.7 and 19.8 min, whereas the range for conventional impressions was 8.8 and 18.4 min. In a fully digital workflow (FD‐WF) for posterior SIC, mean fabrication time ranged between 46.8 and 54.5 min (prefabricated abutment) and 68.0 min (customized abutment). In a hybrid workflow (H‐WF) including a digitally customized abutment and a manual veneering, mean fabrication time ranged between 132.5 and 158.1 min. For a conventional porcelain‐fused‐to‐metal‐crown, a mean time of 189.8 min was reported. The mean time for the delivery of posterior SIC ranged between 7.3 and 7.4 min (FD‐WF), 10.5 and 12.5 min (H‐WF), and 15.3 min (conventional workflow, C‐WF). The FD‐WF for posterior SIC was more effective than the H‐/C‐WF.ConclusionsThe implementation of the studied digital technologies increased time efficiency for the laboratory fabrication of implant‐supported reconstructions. For posterior SIC, the model‐free fabrication, the use of prefabricated abutments, and the monolithic design was most time efficient and most effective.
What is the impact of titanium particles and biocorrosion on implant survival and complications? A critical review
Authors: Mombelli Andrea , Hashim Dena , Cionca Norbert 
Published: October 2018

AbstractObjectivesTo compile the current evidence regarding the association between the release of titanium particles and biologic complications of dental implants.Material and methodsThis is a critical review. We searched the literature using the terms “corrosion,” “allergy,” “hypersensitivity,” or “particles” together with “titanium,” “Ti,” “TiO2.” The bibliographies of identified publications and previously published review articles were scanned to find additional related articles. We included clinical studies, in vivo and in vitro experiments.ResultsTitanium particles and degradation products of titanium have been detected in oral and nonoral tissues. Particles are released from surfaces of dental implants because of material degradation in a process called tribocorrosion. It involves mechanical wear and environmental factors, notably contact to chemical agents and interaction with substances produced by adherent biofilm and inflammatory cells. In vitro, titanium particles can interfere with cell function and promote inflammation. A temporal association between exposure to titanium and occurrence of tissue reactions suggested hypersensitivity in a limited number of cases. However, there is poor specificity as the observed reactions could be initiated by other factors associated with the placement of implants. Titanium particles are commonly detected in healthy and diseased peri‐implant mucosa alike, at low levels even in gingiva of individuals without titanium implants. Rather than being the trigger of disease, higher concentrations of titanium in peri‐implantitis lesions could be the consequence of the presence of biofilms and inflammation.ConclusionThere is an association between biocorrosion, presence of titanium particles, and biological implant complications, but there is insufficient evidence to prove a unidirectional causal relationship.
Is there an effect of crown‐to‐implant ratio on implant treatment outcomes? A systematic review
Authors: Meijer Henny J. A. , Boven Carina , Delli Konstantina , Raghoebar Gerry M. 
Published: October 2018

AbstractObjectivesHigh crown‐to‐implant ratios may lead to complications due to unfavorable occlusal forces, including nonaxial forces, on the bone surrounding the neck of the implant and within the connection of the crown and implant itself. The aim of this study was to perform a systematic review on the influence of crown‐to‐implant ratio of single‐tooth, nonsplinted, implants on biological and technical complications.Materials and MethodsMEDLINE (1950–January 2018), EMBASE (1966–January 2018), and Cochrane Central Register of Controlled Trials database (1800–January 2018) were searched to identify eligible studies. Inclusion criteria were as follows: crown‐to‐implant ratio of single‐tooth, nonsplinted, implant‐supported restorations in the posterior maxilla or mandible and follow‐up of at least 1 year. Main outcome measures were as follows: implant survival rate, marginal bone level changes, biological complications, and technical complications. Two reviewers independently assessed the articles. A meta‐analysis was carried out for implant survival rate and peri‐implant bone changes.ResultsOf 154 primarily selected articles, eight studies fulfilled the inclusion criteria. Study groups presented a mean crown‐to‐implant ratio varying from 0.86 (with 10‐mm implants) to 2.14 (with 6‐mm implants). The meta‐analysis showed an implant survival of more than 99% per year and mean peri‐implant bone changes of <0.1 mm per year. Limited biological and technical complications were reported.ConclusionData reviewed in the current manuscript on crown‐to‐implant ratio, ranging from 0.86 to 2.14, of single‐tooth, nonsplinted, implants did not demonstrate a high occurrence of biological or technical complications.
Clinical outcomes of partial and full‐arch all‐ceramic implant‐supported fixed dental prostheses. A systematic review and meta‐analysis
Authors: Pieralli Stefano , Kohal Ralf‐Joachim , Rabel Kerstin , von Stein‐Lausnitz Manja , Vach Kirstin , Spies Benedikt Christopher 
Published: October 2018

AbstractObjectiveTo assess the survival and technical complication rate of partial and full‐arch all‐ceramic implant‐supported fixed dental prostheses (P‐FDP/FA‐FDP) and supporting implants.Materials and methodsAn electronic search through three databases (MEDLINE/Pubmed, Cochrane Library, Embase) was conducted to identify relevant clinical studies with an observation period of at least 12 months, including ≥15 patients. Reconstruction and implant survival rates, technical complications and confounding variables such as processed/installed materials, retention mode and location in the mouth were obtained. Failure and complication rates were analyzed using standard Poisson regression models to calculate 5‐year survival and complication estimates.ResultsA total of five studies for the P‐FDP group and seven studies for the FA‐FDP group were included, throughout evaluating veneered zirconia reconstructions. In the P‐FDP group, reconstructions were located in posterior regions. Meta‐analysis indicated survival estimates on the reconstruction level of 98.3% and 97.7% for P‐ and FA‐FDPs after 5 years. However, chipping of the veneering ceramic was frequent, resulting in estimated 5‐year complication rates of 22.8% (P‐FDPs) and 34.8% (FA‐FDPs). Five‐year survival estimates of implants supporting P‐FDPs and FA‐FDPs of 98.5% and 99.4% were calculated, respectively. Including a total of 540 FDPs, one screw‐loosening and 11 de‐cementations were reported. Confounding variables were not found to have a significant influence on survival and complication rates.ConclusionsAll‐ceramic implant‐supported P‐ and FA‐FDPs comprising veneered zirconia frameworks showed high survival but clinically inacceptable fracture rates of the veneering ceramic. Their suitability with regard to this indication and a successful long‐term outcome needs to be further evaluated.
Effects of law enforcement and community outreach on mammal diversity in a biodiversity hotspot
Authors: Chen Cheng , Quan Rui‐Chang , Cao Guanghong , Yang Hongpei , Burton A. Cole , Meitner Michael , Brodie Jedediah F. 
Published: October 2018

AbstractManagement activities such as law enforcement and community outreach are thought to affect conservation outcomes in protected areas, but their importance relative to intrinsic environmental characteristics of the parks and extrinsic human pressures surrounding the parks have not been explored. Furthermore, it is not clear which is more related to conservation outcomes—the management itself or local people's perceptions of the management. We measured objective (reports by park staff) and subjective (reports by local people) levels of community outreach and law enforcement based on responses to 374 questionnaires. We estimated mammal abundance and diversity of 6 protected areas based on data from 115 camera traps in Xishuangbanna, southwest China, a biodiversity hotspot with high hunting and land‐conversion pressures. We then examined correlations among them and found that local people's perception of law enforcement was positively related to the local abundance of 2 large, hunted species, wild boar (Sus scrofa) (β = 15.22) and muntjac (Muntiacus vaginalis) (β = 14.82), but not related to the abundance of smaller mammals or to objective levels of enforcement. The subjective frequency of outreach by park staff to local communities (β = 3.42) and park size (β = 3.28) were significantly and positively related to mammal species richness, whereas elevation, human population density, and subjective frequency of law enforcement were not. We could not conclude that community outreach and law enforcement were directly causing increased mammal abundance and diversity. Nevertheless, the patterns we detected are some of the first empirical evidence consistent with the idea that biodiversity in protected areas may be more positively and strongly related to local perceptions of the intensity of park management than to either intrinsic (e.g., elevation, park size) or extrinsic (e.g., human population density) environmental factors.
Metformin synergistically enhances the antitumor activity of the third‐generation EGFR‐TKI CO‐1686 in lung cancer cells through suppressing NF‐κB signaling
Authors: Pan Yong‐Hong , Lin Cai‐Yu , Lu Cong‐Hua , Li Li , Wang Yu‐Bo , Chen Heng‐Yi , He Yong 
Published: October 2018

AbstractPurposeThird‐generation irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‐TKI), rociletinib (CO‐1686), is great efficacy against EGFR‐mutated patients bearing the T790M resistance mutation. However, acquired resistance may emerge. There is a need to characterize acquired resistance mechanism(s) and to devise ways to overcome CO‐1686 resistance.Experimental DesignMTT assay, ki67 incorporation assay, transwell assay and TUNEL assay were employed to analyze the effects of metformin to reverse CO‐1686 resistance in vitro. The NF‐κB activity was measured by the antibody of p50, p65, p‐IKBɑ, and p‐IKKɑ/β. Western blotting was used to analyze the proteins in cells.ResultsWe have established CO‐1686‐resistant cell lines of PC‐9GRCOR and H1975COR from two parental cell lines of PC‐9GR and H1975 by long‐term exposure to increasing doses of CO‐1686. Compared with the parental cells, PC‐9GRCOR cells and H1975COR cells showed 90‐folds and 20‐folds higher resistance to CO‐1686, respectively. Critically, we showed that the nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB) signaling molecular proteins subunits of p50, p65 and its inhibitor proteins of IKBɑ, IKKɑ/β in phosphorylation levels in resistant cells were higher than parental cells. Accordingly, inhibition of NF‐κB activity used TPCA‐1 effective in decreasing viability and inducing apoptosis of resistant cells. Moreover, metformin overcame the acquired resistance to CO‐1686 by reducing cell proliferation and invasion. Metformin combined with CO‐1686 synergistically inhibited the p‐IKBɑ, p‐IKKɑ/β, p50, and p65.ConclusionsNF‐κB signaling activation induced acquired resistance to CO‐1686. Metformin sensitized resistant cells to CO‐1686 via inhibiting NF‐κB signaling.