bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ibrutinib‐associated invasive fungal diseases in patients with chronic lymphocytic leukaemia and non‐Hodgkin lymphoma: An observational study
Authors: Ruchlemer Rosa , Ben‐Ami Ronen , Bar‐Meir Maskit , Brown Jennifer R. , Malphettes Marion , Mous Rogier , Tonino Sanne H. , Soussain Carole , Barzic Noelie , Messina Julia A. , Jain Preetesh , Cohen Regev , Hill Brian , Mulligan Stephen P. , Nijland Marcel , Herishanu Yair , Benjamini Ohad , Tadmor Tamar , Okamoto Koh , Arthurs Benjamin , Gottesman Batsheva , Kater Arnon P. , Talha Munir , Eichhorst Barbara , Korem Maya , Bogot Naama , De Boer Fransien , Rowe Jacob M. , Lachish Tamar 
Published: September 2019

SummaryBackgroundInvasive fungal diseases (IFD) are life‐threatening infections most commonly diagnosed in acute leukaemia patients with prolonged neutropenia and are uncommonly diagnosed in patients with lymphoproliferative diseases.ObjectivesFollowing the initial report of aspergillosis diagnosed shortly after beginning ibrutinib for chronic lymphocytic leukaemia, a survey was developed to seek additional cases of IFD during ibrutinib treatment.MethodsLocal and international physicians and groups were approached for relevant cases. Patients were included if they met the following criteria: diagnosis of chronic lymphocytic leukaemia/non‐Hodgkin lymphoma; proven or probable IFD; and ibrutinib treatment on the date IFD were diagnosed. Clinical and laboratory data were captured using REDCap software.ResultThirty‐five patients with IFD were reported from 22 centres in eight countries: 26 (74%) had chronic lymphocytic leukaemia. The median duration of ibrutinib treatment before the onset of IFD was 45 days (range 1‐540). Aspergillus species were identified in 22 (63%) of the patients and Cryptococcus species in 9 (26%). Pulmonary involvement occurred in 69% of patients, cranial in 60% and disseminated disease in 60%. A definite diagnosis was made in 21 patients (69%), and the mortality rate was 69%. Data from Israel regarding ibrutinib treated patients were used to evaluate a prevalence of 2.4% IFD.ConclusionsThe prevalence of IFD among chronic lymphocytic leukaemia/non‐Hodgkin lymphoma patients treated with ibrutinib appears to be higher than expected. These patients often present with unusual clinical features. Mortality from IFD in this study was high, indicating that additional studies are urgently needed to identify patients at risk for ibrutinib‐associated IFD.
Comparing the effectiveness and adverse effects of pilocarpine and cevimeline in patients with hyposalivation
Authors: Farag Arwa M. , Holliday Craig , Cimmino Joseph , Roomian Tamar , Papas Athena 
Published: September 2019

AbstractObjectivesPilocarpine (PILO) and cevimeline (CEV) are muscarinic acetylcholine receptor agonists that stimulate salivary gland function. The aim of this investigation was to retrospectively run a head‐to‐head comparison for their effectiveness and frequency of adverse effects in patients with hyposalivation.MethodsA retrospective chart review was conducted for patients seen at the Oral Medicine Clinic at Tufts University School of Dental Medicine (TUSDM) and was prescribed PILO or CEV. Patients’ demographics, medical history/medication, stimulated salivary (SS), and unstimulated salivary (US) flow recorded at the initial visit and at 3‐ and 6‐month follow‐ups were collected. Changes in dosage/frequency, side effects, and drug discontinuation were also reported.ResultsA total of 110 patients’ charts were reviewed. The majority of subjects (91%) were females with an average age of 61. At 3‐month follow‐up, the use of CEV showed significant improvement in SS compared to PILO (p = .033) but not in US (p = .10). At 6‐month follow‐up, there was no significant difference in SS or US between the two groups (SS: p = .09; US: p = .71). The use of PILO was associated with a higher proportion of adverse effects compared to CEV (p = .04). The overall adherence rate was significantly higher in the CEV group (p = .0056).ConclusionsThe effectiveness of CEV and PILO is comparable. However, PILO seems to be associated with more reporting of side effects.
Risk factors affecting the prognosis of urinary tract infection in Chinese pediatric patients: Single‐center experience
Authors: Wang Jun , Zhu Haobo , Huang Liqu , Zhu Xiaojiang , Dong Jun , Sha Jintong , Gu Nannan , Ge Zheng , Deng Yongji , Ma Geng , Guo Yunfei 
Published: September 2019

AbstractBackgroundUrinary tract infection (UTI) is common in children. The purpose of this retrospective study was to determine the various risk factors that usually affect the prognosis of UTI in children diagnosed with the disease.MethodsIn the present retrospective study, we enrolled all pediatric patients diagnosed with UTI and hospitalized between 1 January 2013 and 31 July 2016 at Nanjing Children's Hospital. We then collected all the relevant patient clinical demographics and characteristics.ResultsThe study involved 2,092 pediatric patients diagnosed with UTI. On logistic regression analysis, factors that could affect the prognosis of pediatric UTI were complications, hospitalization, intensive care unit (ICU) admission, type of UTI, urine culture results, blood lymphocytes, urine nitrites (NIT) and antibiotics (unstandardized coefficients, 0.06, <0.001, −0.28, 0.32, <0.001, 0.01, −0.11, 0.01, respectively, all P < 0.001).ConclusionComplications, hospitalization, type of UTI, urine culture results, blood lymphocytes, and antibiotics had a significant, positive association with UTI prognosis. Meanwhile, ICU admission and urine NIT had a negative association with prognosis.
Pediatric electrical injury in Turkey: Five year retrospective hospital‐based study
Authors: Ozdel Semanur , Cakıcı Evrim Kargın , Sayli Tülin Revide 
Published: September 2019

AbstractBackgroundWe aimed to evaluate children who presented with electrical injury to the emergency department. We tried to reveal the complications of these patients and the measures to be taken in this regard.MethodsMedical records of pediatric patients who were admitted with electrical injury to emergency department between January 2007 and January 2012 were retrospectively reviewed. An information form was completed about demographic data, clinical features, exposure place, electrical current type, clinical course, duration of hospitalization, electrocardiography, echocardiography and other systems findings.ResultsChildren who were the most exposed to electrical injury were children 4 years and under. While low‐voltage current exposure was more common in younger ages, high‐voltage current exposure was more common in older ages. Most of our patients (%72) were exposed to low voltage. Patients who exposed to high‐voltage electricity had significantly higher levels of CPK, CK‐MB, LDH, AST, and ALT compared to patients who were exposed to low voltage electricity. None of the patients have died.ConclusionYoung children are often exposed to electric shock at home. Increasing precautions to be taken at home reduces electrical shock injuries. Children and especially families should be educated in this regard.
Motivated to be socially mindful: Explaining age differences in the effect of employees’ contact quality with coworkers on their coworker support
Authors: Fasbender Ulrike , Burmeister Anne , Wang Mo 
Published: September 2019

AbstractIn this research, we examine how high‐quality contact can facilitate employees’ coworker support and explain why the benefits of high‐quality contact are contingent upon age. First, we employ a social mindfulness lens to decipher the motivational mechanisms of high‐quality contact with coworkers on providing coworker support via coworker‐oriented perspective taking and empathic concern. Second, we utilize socioemotional selectivity theory to overcome the current age‐blind view on workplace interactions and examine the indirect moderating effect of age via future time perspective on the link between contact quality, social mindfulness, and coworker support. We tested our hypotheses based on data from a sample of 575 employees collected in three waves. Results showed that both coworker‐oriented perspective taking and empathic concern mediated the positive effects of contact quality on coworker support. The effect of contact quality on coworker‐oriented empathic concern was stronger for older employees with a more constrained future time perspective as compared to younger employees with a more extensive future time perspective. Overall, we extend research on aging, workplace interactions, and support behavior by linking the literature on these topics using a social mindfulness lens and by adding employee age and age‐related mechanisms as important boundary conditions that qualify the outcomes of positive workplace contact.
Application of energy‐filtering electron microscopy (EFEM) for analysis of hydrogen peroxide and lignin in epidermal walls of cucumber leaves triggered by acibenzolar‐S‐methyl treatment prior to inoculation with Colletotrichum orbiculare
Authors: Park P. , Kurihara T. , Nita M. , Ikeda K. , Inoue K. , Ishii H. 
Published: September 2019

Hydrogen peroxide (H2O2) and lignin induced by acibenzolar‐S‐methyl (ASM) during the expression of systemic acquired resistance (SAR) of cucumber plants against the fungus Colletotrichum orbiculare was analysed with electron microscopy and energy‐filtering electron microscopy (EFEM). ASM pretreatment consistently led to the blockage of appressorial penetration pegs into leaves at early stages after inoculation, whereas the fungus was able to grow into the vascular tissue after distilled water pretreatment. The blocked pegs, seen frequently at epidermal pectin layers in leaves of ASM‐treated plants, were surrounded by abundant electron‐dense amorphous material and dots. These were identified as lignin, based on their appearance and high reactivity with KMnO4. Lignin first appeared as an amorphous material at pectin layers, and then as dots in some areas of the material. The results showed that ASM caused SAR in leaves via faster formation of lignin within 1 day after inoculation. After CeCl3 treatment to detect H2O2, H2O2‐reactive products (cerium perhydroxides) were seen near ASM‐induced lignin formation sites in pectin layers. EFEM analysis showed that Ce and O were located at the same sites as the lignin dots, suggesting that lignin was associated with sources of H2O2 generation. The results indicate that the faster H2O2 generation and lignification induced by ASM were the potential causes of SAR.
Fish trait preferences: a review of existing knowledge and implications for breeding programmes
Authors: Mehar Mamta , Mekkawy Wagdy , McDougall Cynthia , Benzie John A.H. 
Published: September 2019

AbstractContinued growth of the aquaculture sector will rely on the availability of fish with traits that respond to the needs and preferences of these users along the value chain. Such trait responsiveness requires that fish breeding programmes have reliable knowledge of these users’ trait preferences. The present study found from a non‐systematic literature review, that no fish breeding programme had reported user preference in their product‐profile design. A systematic literature review was then carried out to identify studies which have assessed fish trait preferences of different users, categorized by market segment and gender. This identified relatively few such studies (n = 28 total), highlighting a lack of published information in this area. Some preferences were shared broadly among a range of users (e.g. size measures such as length or weight). A number of traits were of restricted preferences such as survival (important to farmers, hatchery and nursery operators) while appearance or taste dominated in the preferences for traders and consumers. Some of the preferred traits of users are not targets for selection in breeding programmes reported to date (e.g. body texture, nutritional value) The review also makes clear that there can be range of preferences that differ by gender and social or economic status of the user. Greater acceptance of more sustainable aquaculture products will require improved information on user preferences. This will need innovative tools to translate generally expressed preferences into well‐defined traits and to assess their trade‐offs for their incorporation in genetic improvement programmes that will better target benefits to users.
Effects of melatonin on morphology and development of primordial follicles during in vitro culture of bovine ovarian tissue
Authors: Cavalcante Barbara N. , Matos‐Brito Bruno G. , Paulino Lais R. F. M. , Silva Bianca R. , Aguiar Antonio Wesley Melo , de Almeida Edmar Felipe Maia , Souza Ana Liza Paz , Vasconcelos Gisvani Lopes , De Assis Ernando Igo Teixeira , Silva Anderson W. B. , Silva José Roberto V. 
Published: September 2019

AbstractThis study aims to investigate the effect of melatonin on activation, growth and morphology of bovine primordial follicles, as well as on stromal cells density in ovarian tissues after in vitro culture. Ovarian fragments were cultured in α‐MEM+ alone or supplemented with melatonin (250, 500, 1,000 or 2,000 pM) for a period of six days. Non‐cultured and cultured tissues were processed for histological analysis; according to developmental stages, follicles were classified as primordial or growing follicles. These follicles were further classified as morphologically normal or degenerated. Ovarian stromal cell density was also evaluated. The percentages of primordial and developing follicles, as well as those classified of normal follicles, were compared by Fisher's exact test, and the differences were considered significant when p < .05. The results showed that the presence of 1,000 and 2,000 pM melatonin in culture medium promoted a reduction in the percentage of primordial follicles and an increase in the percentage of development follicles, when compared to follicles cultured in control medium. On the other hand, the presence of 250 or 500 pM melatonin did not show a significant effect on the percentage of primordial and developing follicles. Besides that, the presence of 500, 1,000 and 2,000 pM melatonin maintained the percentage of normal follicles similar to those seen uncultured control. Moreover, tissues cultured in presence of 1,000 pM melatonin showed a higher percentage of normal follicles when compared to follicles cultured in the presence of 250 pM melatonin. It was observed a similar profile of stromal density in both uncultured tissues and those cultured in vitro in the presence of melatonin. In conclusion, melatonin (1,000 and 2,000 pM) promotes bovine primordial follicles activation and maintains the stromal cell density during in vitro culture of ovarian cortical tissue.
Respiratory and allergic disorders in children with severe and partial immunoglobulin A immunodeficiency
Authors: Živković Jelena , Lipej Marcel , Banić Ivana , Bulat Lokas Sandra , Nogalo Boro , Lulić Jurjević Rajka , Turkalj Mirjana 
Published: September 2019

AbstractBackgroundImmunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency. Although most people with selective IgAD (sIgAD) are asymptomatic, many patients often suffer from recurrent respiratory infections and different allergic disorders. Our aim was to investigate connection between subtypes of sIgAD and incidence of respiratory and allergic disorders, as well as connection with lung function changes in children.MethodsChildren with IgAD where divided into two groups; severe IgAD in patients was defined as serum IgA level <7 mg/dL, while partial IgA deficiency diagnosis was made when serum IgA levels was higher than 7 mg/dL but at least two standard deviations (SD) below mean normal concentrations for their age. All patients were evaluated by their clinical and laboratory investigation parameters and compared to control group of children.ResultsGroup of children with IgAD, severe as well as partial, showed higher prevalence of allergic diseases and total number of infections, compared to controls. There was a statistically significant difference in lung function for peak expiratory flow (PEF), the maximal expiratory flow at 50% of the forced vital capacity (MEF50) and fraction of exhaled nitric oxide (FENO) between group of patients with severe as well as partial IgAD and control group, where children with IgAD showed reduced lung function.ConclusionsChildren with sIgAD are at increased risk for higher number of respiratory infections and developing allergic diseases, resulting in significantly lower pulmonary function which is related with the severity of sIgAD.
Correlations of cytokine levels in cerebrospinal fluid and peripheral blood with outcome of HHV‐6B encephalitis after hematopoietic stem cell transplantation
Authors: Takano Kuniko , Ogata Masao , Satou Takako , Miyazaki Yasuhiko , Otsuka Eiichi , Saito Noriyuki , Ueki Toshimitsu , Kako Shinichi , Fukuda Takahiro , Shirao Kuniaki 
Published: September 2019

AbstractBackgroundHuman herpesvirus (HHV)‐6B encephalitis has been recognized as a serious complication after allogeneic hematopoietic cell transplantation (allo‐HCT). Little is known about the pathogenic mechanism for its progression.Study DesignWe retrospectively evaluated the 16 kinds of cytokines and chemokines in cerebrospinal fluid (CSF) and plasma in patients who developed HHV‐6B encephalitis. Among a total of 20 patients, 12 were categorized as the poor prognosis group (died of encephalitis; n = 8 and retained sequelae; n = 4), and other eight patients were categorized as the good prognosis group (complete recovery; n = 8).ResultsConcentrations of CSF IL‐6 and IL‐8 at the onset of encephalitis were significantly higher in the poor prognosis group than in the good prognosis group (median CSF IL‐6, 28.27 pg/mL vs 14.32 pg/mL, P = .004; median CSF IL‐8, 128.70 pg/mL vs 59.43 pg/mL, P = .043). Regarding plasma, the concentration of each cytokine at the onset of encephalitis was not significantly different between the two groups, except IL‐5. However, higher levels of IL‐6, IL‐7, and MCP‐1 and lower levels of IL‐12 were observed 1 week before the development of encephalitis in patients with poor prognosis (median IL‐6; 464.17 pg/mL vs 47.82 pg/mL, P = .02; median IL‐12; 1.63 pg/mL vs 6.57 pg/mL, P = .03).ConclusionWe found that one week before onset of HHV‐6B encephalitis, poor prognosis patients had high plasma concentrations of IL‐6, IL‐7, and MCP‐1 and low concentrations of IL‐12. At the onset of encephalitis, high concentrations of IL‐6 and IL‐8 in CSF were more common in the poor prognosis group, consistent with other evidence that IL‐6 can have a role in CNS disturbances. Our findings show that specific cytokine status is associated with severe brain damage in patients with HHV‐6B encephalitis, demonstrate prognostic value of plasma IL‐6 concentrations, and suggest evaluation of anti‐cytokine therapeutics in patients with HHV‐6B encephalitis.
DNA‐HPV transition rate and related factors in HPV‐infected women in Can Tho city, Vietnam
Authors: Duong Linh My , Pham Linh Van , Pham Tam Thi , Tran Dung Ngoc , Bui Nghia Quang , Tran Hung Do , Vo Trang Huynh 
Published: September 2019

AbstractObjectivesTo determine DNA‐HPV transition rates and related factors in HPV‐infected women 18–69 years of age in Can Tho City from 2013 to 2018.MethodsBoth a retrospective and a prospective cohort study were done. Interviews, gynaecological examinations and HPV testing by PCR (cervical fluid) were used to collect data. The results were recorded and compared with those of HPV in 2013 to assess the development of HPV over time. Transition was defined as conversion to HPV‐positive state in 2018 from a negative state in 2013. No transition was defined as clearance of HPV when the positive 2013 result was negative in 2018 or when the result remained negative or positive in 2013 and 2018. Factors related to the change were analysed.ResultsAmong a sample size of 204 cases, the average age of participants was 48.9 ± 10.4 years. Women >45 comprised 63.2% of participants; 82.8% lived with their husbands, 6.4% were divorced, and 2.9% lived apart from their husbands due to work. After 5 years of observation, 16.2% of DNA‐HPV cases had converted to HPV‐positive state and 66.2% of DNA‐HPV cases had cleared to HPV‐negative state. Factors related to conversion to HPV‐positive state were age ≤ 45 years (3.14 times higher risk of transition than in the >45 age group (95% CI: 1.12–8.8)); change of sexual partner (OR = 3.75 (95% CI: 1.15–12.2)); change of sexual partner by husband (OR = 3.69 (95% CI: 1.20–11.3); sexually transmitted diseases (OR = 5.19 (95% CI: 1.09–24.8)); and a history of vacuum aspiration or dilation and evacuation abortion (OR = 1.4 (95% CI: 0.29–6.4)).Conclusions16.2% of women with DNA‐HPV transition converted to HPV‐positive state. Changes in sexual habits increase the risk of developing HPV positivity.
Drug‐related problems in prescribing for coronary artery diseases in Vietnam: cross‐sectional study
Authors: Truong Thu T. A. , Phan Ngan K. , Vo Quyen V. , Diep Han G. , Vuong Huyen T. K. , Le Thanh V. , Nguyen Phuong M. , Nguyen Thang 
Published: September 2019

AbstractObjectivesTo determine the prevalence, patterns and determinants of drug‐related problems (DRPs) in prescribing for coronary artery diseases (CADs) in Vietnam.MethodsRetrospective cross‐sectional study on outpatients with CADs at a general hospital in Can Tho, Vietnam. DRPs were classified according to Pharmaceutical Care Network Europe definitions. We determined the prevalence and patterns of DRPs. Logistic regression was used to identify the determinants of DRPs.ResultsAmong 683 patients (mean age 63.4; 64.3% female), the prevalence of DRPs was 61.1%. DRPs comprised inappropriate indication (3.5%), inappropriate dosage (22.2%), wrong frequency of use (24.2%), wrong time of taking medications (4.1%), taking medications at the wrong time around meals (19.2%) and drug interactions (19.3%). Patients who took ≥ 5 drugs were more likely to have DRPs (adjusted odds ratio = 1.96; 95% confidence interval = 1.31–2.93). Patients without health insurance were more likely to have inappropriate indication (ORa = 2.93; 95%CI = 1.28–6.70). Taking medications at inappropriate times around meals was common among men (ORa = 1.82; 95%CI = 1.23–2.69) and among those with health insurance (ORa = 1.66; 95%CI = 1.05–2.63). Patients < 65 years old were more likely to be prescribed inappropriate doses (ORa = 1.67; 95%CI = 1.15–2.45). Prescriptions with ≥ 5 drugs were more likely to be taken at inappropriate frequency (ORa = 1.87; 95%CI = 1.09–3.21) and to cause drug interactions (ORa = 6.48; 95%CI = 2.59–16.24).ConclusionsDRPs are common among patients with CADs in Vietnam. The number of DRPs increases with the number of drugs in prescriptions. Further studies should identify other potential determinants of DRPs and effective interventions to improve prescribing practice in Vietnam.