bluuebunny/crossref_metadata_2025_split huggingface dataset:
Charge disproportionation and site-selective local magnetic moments in the post-perovskite-type Fe2O3 under ultra-high pressures
Authors: Leonov Ivan , Rozenberg Gregory Kh. , Abrikosov Igor A. 
Published: September 2019

AbstractThe archetypal 3d Mott insulator hematite, Fe2O3, is one of the basic oxide components playing an important role in mineralogy of Earth’s lower mantle. Its high pressure–temperature behavior, such as the electronic properties, equation of state, and phase stability is of fundamental importance for understanding the properties and evolution of the Earth’s interior. Here, we study the electronic structure, magnetic state, and lattice stability of Fe2O3 at ultra-high pressures using the density functional plus dynamical mean-field theory (DFT + DMFT) approach. In the vicinity of a Mott transition, Fe2O3 is found to exhibit a series of complex electronic, magnetic, and structural transformations. In particular, it makes a phase transition to a metal with a post-perovskite crystal structure and site-selective local moments upon compression above 75 GPa. We show that the site-selective phase transition is accompanied by a charge disproportionation of Fe ions, with Fe3±δ and δ ~ 0.05–0.09, implying a complex interplay between electronic correlations and the lattice. Our results suggest that site-selective local moments in Fe2O3 persist up to ultra-high pressures of ~200–250 GPa, i.e., sufficiently above the core–mantle boundary. The latter can have important consequences for understanding of the velocity and density anomalies in the Earth’s lower mantle.
Calcineurin regulates cyclin D1 stability through dephosphorylation at T286
Authors: Goshima Takahiro , Habara Makoto , Maeda Keisuke , Hanaki Shunsuke , Kato Yoichi , Shimada Midori 
Published: September 2019

AbstractThe Calcineurin/NFAT (nuclear factor of activated T cells) pathway plays an essential role in the tumorigenic and metastatic properties in breast cancer. The molecular mechanism of the antiproliferative effect of calcineurin inhibition, however, is poorly understood. We found that calcineurin inhibition delayed cell cycle progression at G1/S, and promoted cyclin D1 degradation by inhibiting dephosphorylation at T286. Importantly, overexpression of cyclin D1 partially rescued delayed G1/S progression, thereby revealing cyclin D1 as a key factor downstream of calcineurin inhibition. Cyclin D1 upregulation is observed in human invasive breast cancers, and our findings indicate that dysregulation of T286 phosphorylation could play a role in this phenomenon. We therefore propose that targeting site specific phosphorylation of cyclin D1 could be a potential strategy for clinical intervention of invasive breast cancer.
Phospholipase C-related catalytically inactive protein regulates cytokinesis by protecting phosphatidylinositol 4,5-bisphosphate from metabolism in the cleavage furrow
Authors: Asano Satoshi , Ikura Yasuka , Nishimoto Mitsuki , Yamawaki Yosuke , Hamao Kozue , Kamijo Keiju , Hirata Masato , Kanematsu Takashi 
Published: September 2019

AbstractCytokinesis is initiated by the formation and ingression of the cleavage furrow. Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] accumulation followed by RhoA translocation to the cleavage furrow are prerequisites for cytokinesis progression. Here, we investigated whether phospholipase C (PLC)-related catalytically inactive protein (PRIP), a metabolic modulator of PI(4,5)P2, regulates PI(4,5)P2-mediated cytokinesis. We found that PRIP localised to the cleavage furrow during cytokinesis. Moreover, HeLa cells with silenced PRIP displayed abnormal cytokinesis. Importantly, PI(4,5)P2 accumulation at the cleavage furrow, as well as the localisation of RhoA and phospho-myosin II regulatory light chain to the cleavage furrow, were reduced in PRIP-silenced cells. The overexpression of oculocerebrorenal syndrome of Lowe-1 (OCRL1), a phosphatidylinositol-5-phosphatase, in cells decreased PI(4,5)P2 levels during early cytokinesis and resulted in cytokinesis abnormalities. However, these abnormal cytokinesis phenotypes were ameliorated by the co-expression of PRIP but not by co-expression of a PI(4,5)P2-unbound PRIP mutant. Collectively, our results indicate that PRIP is a component at the cleavage furrow that maintains PI(4,5)P2 metabolism and regulates RhoA-dependent progression of cytokinesis. Thus, we propose that PRIP regulates phosphoinositide metabolism correctively and mediates normal cytokinesis progression.
CDAP: An Online Package for Evaluation of Complex Detection Methods
Authors: A. Maddi Ali M. , Ahmadi Moughari Fatemeh , Balouchi Mohammad Mehdi , Eslahchi Changiz 
Published: September 2019

AbstractMethods for detecting protein complexes from protein-protein interaction networks are of the most critical computational approaches. Numerous methods have been proposed in this area. Therefore, it is necessary to evaluate them. Various metrics have been proposed in order to compare these methods. Nevertheless, it is essential to define new metrics that evaluate methods both qualitatively and quantitatively. In addition, there is no tool for the comprehensive comparison of such methods. In this paper, a new criterion is introduced that can fully evaluate protein complex detection algorithms. We introduce CDAP (Complex Detection Analyzer Package); an online package for comparing protein complex detection methods. CDAP can quickly rank the performance of methods based on previously defined as well as newly introduced criteria in various settings (4 PPI datasets and 3 gold standards). It has the capability of integrating various methods and apply several filterings on the results. CDAP can be easily extended to include new datasets, gold standards, and methods. Furthermore, the user can compare the results of a custom method with the results of existing methods. Thus, the authors of future papers can use CDAP for comparing their method with the previous ones. A case study is done on YGR198W, a well-known protein, and the detected clusters are compared to the known complexes of this protein.
Investigating reproductive success of the ladybird beetle Harmonia axyridis from the perspective of micropyle variation
Authors: Sun Yuan-Xing , Hao Ya-Nan , Liu Chang-Zhong , Wang Sen-Shan 
Published: September 2019

AbstractMicropyles in insects are small openings that allow sperm entry into, and the number was usually decreased on unfertilized and (or) undeveloped eggs. However, reports showed that Harmonia axyridis, a reproductive success model, deposited similar number of micropyles on undeveloped and developing eggs. Thus, it was confusing whether micropyles in H. axyridis were unaffected. To solve this confusion, two experiments were conducted here. Firstly, virgin female and four different days delayed mating (DDM) experiments were conducted to reveal the effects of fertilization stimulus and delayed-fertilization. Secondly, intercrosses between a light-colored mutant (HAM, an adaptive deficiency) and wild type (HAW) were conducted to further reveal whether there were female and male interactions. We found that (1) eggs produced by virgin and DDM females had significantly less micropyles than control. Even so, more than 18 micropyles were observed on eggs following fertilization and, consequently, egg production as well as hatch rate was not negatively affected by mating delay; (2) number of micropyles was significantly varied among the four reciprocal crosses and virgin HAW female. Specifically, the heterozygous eggs (Cross-D) and wild-type homozygous eggs (Cross-B) respectively had the least and maximum micropyles, and eggs from virgin HAW female had significantly less micropyles compared to those from HAW female (Cross-B or Cross-C), but the number was significantly higher than those from HAM female (Cross-A or Cross-D). These results informed us that the number of micropyles in H. axyridis is plastic but maintaining a high-quantity that offers many benefits, which should contribute to its reproduction success.
Sex-specific up-regulation of lncRNAs in peripheral blood of patients with schizophrenia
Authors: Fallah Hamid , Azari Iman , Neishabouri Seyedeh Morvarid , Oskooei Vahid Kholghi , Taheri Mohammad , Ghafouri-Fard Soudeh 
Published: September 2019

AbstractSchizophrenia as a common disabling psychiatric disorder has been associated with dysregulation of several genes and pathways among them are those being regulated by long non-coding RNAs (lncRNAs). Based on the acknowledged roles of lncRNAs in neurodevelopment, in the current study, we assessed expression of six lncRNAs namely HOXA-AS2, Linc-ROR, MALAT1, MEG3, SPRY4-IT1 and UCA1 in peripheral blood of 60 patients with schizophrenia and 60 healthy subjects. HOXA-AS2, Linc-ROR, MEG3, SPRY4-IT1 and UCA1 levels were significantly higher in total patients compared with total controls. However, when evaluating expression of genes in sex-based subgroups, the differences in the expression of these lncRNAs were significant only among females. Assessment of partial correlation between expression of lncRNAs and age of study participants after controlling the effect of sex, revealed significant correlations for HOXA-AS2, MALAT1 and UCA1 in both patients and controls. Besides, expressions of Linc-ROR and SPRY4-IT1 were correlated with age only in patients. Significant pairwise correlations were recognized between expression levels of lncRNAs in both patients with schizophrenia and controls. Based on the area under curve (AUC) values, SPRY4-IT1 had the best performance in differentiation of female patients with schizophrenia from female controls (AUC = 0.85, P < 0.0001). Combination of Linc-ROR, MEG3, SPRY4-IT1 and UCA1 expression levels could differentiate female patients with 95.2% sensitivity, 76.9% specificity and diagnostic power of 0.88 (P < 0.0001). The current study suggests the presence of a sex-based dysregulation of lncRNAs in patients with schizophrenia and their possible application as diagnostic biomarkers.
A Comparison of Visual- and Movement-Based Grammar Interventions for School-Age Children With Language Impairment
Authors: Springle Alisha P. , Hester Peggy P. 
Published: September 2019

Purpose
The impact of visual- and movement-specific intervention techniques for developing grammatical morphemes in the spoken language of two 6-year-old female children with language impairment was measured.

Method

An adapted alternating treatment single-subject study examined the grammar outcomes from the use of Shape Coding (i.e., using shapes, colors, and arrows to teach grammatical rules;
Ebbels, van der Lely, & Dockrell, 2007
) and an equivalent researcher-designed kinesthetic-/movement-based set of cues.

Results
Interventions were successfully provided by novice clinicians with limited training. Results indicated improvement across both students and were differentiated between students and intervention techniques.

Conclusion
These positive findings support the use of Shape Coding and movement-based interventions targeting language improvement. School-based clinicians should consider multiple modalities for therapeutic instruction with children with language impairment.

Supplemental Material

https://doi.org/10.23641/asha.9454127
Short-term results (1 year) of vented versus solid polyetheretherketone anchors in treatment of rotator cuff tears
Authors: Sarmento Marco C. , Cartucho António E. , Monteiro Jacinto M. 
Published: September 2019

Background: Due to the rotator cuff retear after being surgically repaired, some strategies have been developed. The authors verified that the possibility of polyetheretherketone (PEEK) vented anchors promoted a better clinical and healing process than PEEK solid anchors.Methods: A prospective and randomized study was designed with 38 patients treated with PEEK anchors, 18 of whom with vented anchors and 20 with solid ones. Demographic, clinical and radiologic data were collected before and during surgery (time 0) and at 12 months of follow-up.Results: In the final follow-up (12 months), there was no difference in the visual analogic scale (VAS) scale between groups (1.7 points vs 1.9 points;p = 0.731), neither in the DASH score (34.2 points vs 23.9 points;p = 0.268), nor in absolute Constant score (76.9 points vs 77.3 points;p = 0.910). In MRI, 10 patients had their cuff tear healed in the vented group and 15 in the solid group (p = 0.173).Conclusion: The new designed vented anchors do not add any advantage when compared to solids ones, at least within the first year after surgery.
Many human RNA viruses show extraordinarily stringent selective constraints on protein evolution
Authors: Lin Jinn-Jy , Bhattacharjee Maloyjo Joyraj , Yu Chun-Ping , Tseng Yan Yuan , Li Wen-Hsiung 
Published: September 2019

SignificanceThe nonsynonymous substitutions (dN)-to-synonymous substitutions (dS) ratio in protein-coding genes is commonly used to study the mechanisms of gene evolution. To understand why RNA viruses show large variations indN/dS, we studied thedN/dSratios in 21 human RNA viruses, 8 human DNA viruses, and 17 mammals. Eighteen RNA viruses, but only 2 DNA viruses and no mammals, showed a genome-averagedN/dS< 0.10. Thus, many human RNA viruses exhibited extraordinarily stringent selective constraints on protein evolution. Our among-gene and among-species comparisons revealed that both positive selection and population size play significant roles in thedN/dSvariation among genes and species. This study clarified several controversial issues and increased our understanding of the mechanisms of RNA virus evolution.
High-throughput sequencing reveals biofluid exosomal miRNAs associated with immunity in pigs
Authors: Zhang Jie , Luo Hui , Xiong Zibiao , Wan Kun , Liao Qinfeng , He Hang 
Published: September 2019

ABSTRACT
Large numbers of miRNAs are found in biofluid exosomes. We isolated ~50–200 nm diameter exosomes from four types of porcine biofluid (urine, plasma, semen, and bile) using serial centrifugation and ultracentrifugation procedures. A total of 42.15 M raw data were generated from four small RNA libraries. This produced 40.17 M map-able sequences, of which we identified 204 conserved miRNAs, and 190 novel candidate miRNAs. Furthermore, we identified 34 miRNAs specifically expressed in only one library, all with well-characterized immune-related functions. A set of five universally abundant miRNAs (miR-148a-3p, miR-21-5p, let-7f-5p, let-7i-5p, and miR-99a-5p) across all four biofluids was also found. Function enrichment analysis revealed that the target genes of the five ubiquitous miRNAs are primarily involved in immune and RNA metabolic processes. In summary, our findings suggest that porcine biofluid exosomes contain a large number of miRNAs, many of which may be crucial regulators of the immune system.
Changes in the phase composition depending on the sizes of Zr–based bulk alloys
Authors: Drozdenko A A , Matveev D V , Pershina E A , Aronin A S 
Published: September 2019

Abstract
The crystalline phases formed during quenching of Zr–based amorphizing alloy; depending on the sample, sizes and position in it, have been identified. The samples of amorphous, partially crystalline, and crystalline alloys have been obtained by levitation melting and quenching into a copper mould of variable diameter.
Mutual self-organization of dislocations, phonons, electrons and photons during plastic deformation of crystals
Authors: Klassen N V , Myshliaev M M 
Published: September 2019

Abstract
Periodical structures of dislocations and other structural defects are found in crystals subjected to various kinds of plastic deformation. These periodicities exist in a wide range of scales from tens of millimeters to tens of nanometers. Periodical systems of structural defects are combined with especial resonant systems of phonon, electron and photon excitations due to long-distant interactions between them. This self-organization of mutually bound distortions of regular crystalline lattice, phonons, electrons and photons are capable to influence significantly on the processes of modifications of crystalline structure by mechanical, magnetic, radiation and other external forces.
Modeling of conductive states in polymer nanocomposites with disordered GaAs nanowire array
Authors: Elnikova L V , Ponomarenko A T , Shevchenko V G 
Published: September 2019

Abstract
We provide numerical Monte Carlo modeling of conductive properties of polymer composites, comprised by doping a polymer matrix with carbon nanotubes and III-IV GaAs nanowires. We apply the basic Su-Schrieffer-Heeger model, which is considered universal for every component of such ternary systems, and in a general case with required parameters. Such modeling of conductive characteristics is motivated by requirements of optimization of geometry and structure of novel photovoltaic devices.
Parameters of electromagnetic pollution from different sources and their hazard impact
Authors: Frah M A A , Belyaev V V 
Published: September 2019

Abstract
During this recent year and a cording development of technology and electronic and software, unexpected kind of pollution among this type of technology appear in our life, this is electromagnetic radiation (EMR), which expose to people, which has Surprisingly risen. For the people who is connected with technology or not, it is important that they have sufficient information about EMF emitting from the equipment that related to field they are in. Therefore, EMR is not only described, but the effects of EMR sources have also been studied in this paper. EMR is basically divided into two parts which are ionizing radiation and non-ionizing radiation. In the other way the techniques we use most often in every life are exposed to radio wave electromagnetic radiation, as the telecommunication systems and microwave oven. but, EMR emitted from these systems it almost has largely ignored due to their low energy level, where it has greatly hazard with the passage time and increased of exposure to this type of radiation. However, EMR ionizing as x-ray, and medical equipment, hence, this type almost related by special way just to people inside this fields and it has personally exposure. more importance they must know about its impact hazard informed about, then they should be having protective to avoid this dangerous type of radiation. on other side all must be caution for their health. The definition of EMR and sources of radiation are very importance for all people must know about the radiation emitted from each device and by details, in order to be obtain their protection to avoid the exposure for radiation in direct way.
Analytical estimation of relative maximum of molecular pairs distribution in shock wave
Authors: Kuznetsov M M , Kuleshova Y D , Perov A A , Smotrova L V 
Published: September 2019

Abstract
Results on an analytical study of the translational nonequlibrium effect in the shock wave are presented. They were formulated systematically in authors articles. The analytical models of high“velocity translational nonequlibrium in binary gas mixtures are considered. A correct analytical calculation for maximum value of molecular pairs distribution in the shock-compressed gas mixtures is given.
Mesogens Orientation on Spherical Interfaces
Authors: Vasilchikova E N , Barabanova N N , Gevorkyan E V , Zhachkin V A , Bogdanov D L , Dadivanyan A K 
Published: September 2019

Abstract
The method of determination of the order parameter in surface layers oriented at spherical and cylindrical interfaces from azimuthal and radial distributions of interference bands intensity observed in polarized light is proposed. Values of the order parameter for transition state of the system ‘isotropic solution – crystal’ (benzene – para-azoxyanisole) are found.
Efficiency of Aspergillus sp. 3 to reduce chromium, sulfide, ammonia, phenol, and fat from batik wastewater
Authors: Dewi R S , Kasiamdari R S , Martani E , Purwestri Y A 
Published: September 2019

Abstract
Batik coloring waste contains heavy metal chromium (Cr), and other components such as, Sulfide (S2-), Ammonia (NH3), phenol and oil-fat. The Batik industries are generally classified as small and medium enterprises, which usually do not process their waste. The aim of this study was to observe the ability of Aspergillus sp. 3 to reduce the concentration of Cr, sulfide, ammonia, phenol, and oil-fat component from batik wastewater. The selected fungus, Aspergillus sp. 3 was isolated from batik waste. Based on previous study, selected fungus, Aspergillus sp. 3 was able to decolorize and remediate Indigosol Blue batik wastewater. Potato dextrose broth medium was used for growing the mycelium. Reduction process was occurred with omitted of medium (formed mycelium-supplemented the batik wastewater). Based on experiments, Aspergillus sp. 3 was able to reduce 89.09%, 83.05%, 56.37%, 48.48%, 95.09%, 32.56, 39.28 and 38.15% of Cr sulfide, NH3, phenol and total oil-fat concentration, respectively. Aspergillus sp. 3 had potential application in bioremediation of water polluted by batik wastewater.
Coleus cultivars (Solenostemon scutellarioides (L.) Codd.) as potential bioindicators of chronic ozone exposure
Authors: Padri M , Umponstira C 
Published: September 2019

AbstractSensitivity of plant under ozone exposure can indicate its potency of being important bioindicator. Early studies have found that coleus plant (Solenostemon scutellarioides(L.) Codd.) has a potency to be ozone bio-indicator. This study aims to investigate the effect of chronic ozone exposure on root and leaf biomass and to quantify any change based on the plant appearance. Four different cultivars of coleus plant with different colour namely fully green (FG), green purple (GP), yellow purple (YP), and reddish (RD) had been selected. These four cultivars were fumigated with three different concentrations of ozone gas (≤ 10 ppb, 40 ppb, and 150 ppb) for 8 hours fumigation during 30-day period of experiment. All cultivars showed a stable leaf biomass after 30-day period of ozone exposure. Similarly, root biomass of all cultivars was not significant changed after fumigation period. Nonetheless, magnitude of ozone symptoms on leaf showed variation in certain cultivars. FG cultivar showed a significant number of chlorosis leaves under 40 and 150 ppb ozone exposure. The exposure of 150 ppb ozone also caused a noticeable percentage of curling leaves on RD cultivar. Moreover, the purple area in YP and GP showed a larger ratio under exposure of 150 ppb ozone. Consequently, coleus plants displayed resistance responds in terms of biomass. On the other hand, the plants also revealed variation in leaf symptom magnitudes and colour patterns under ozone exposure. However, these cultivars are potential to be bio-indicator due to their sensitivity in terms of appearance.