bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study of the Effect of Post-Heating Pulse on Hot Cracking Susceptibility in Pulsed Laser Welding of Invar Alloy
Authors: Zhao DongSheng , Huang ZhenYu , Liu YuJun , Miao Tangjun 
Published: December 2018

Hot cracking is one of the major challenges in laser welding of Invar alloy. In this study, welding hot cracking susceptibility experiments are conducted with fish-bone-type Invar alloy sheets under pulsed laser welding condition. The pulse wave consists of two distinct power levels: welding pulse and post-heating pulse. The welding temperature field can be controlled by changing the duration of the post-heating pulse. The results of experimental measurements and finite element method calculation show that increasing of the post-heating pulse duration leads to a decline in the cooling rate of weld metal within the brittle temperature range, although the welding hot cracking susceptibility decreases at first and then increases. Neither the heat input nor the cooling rate is the only decisive factor for hot cracking during the welding process.

1. Introduction
Invar alloy is widely applied in precision measurement devices and low-temperature-resistant structures for its low linear expansion coefficient at ambient temperature, which is less than 1.6 × 10—6 k—1, about 1/10 of the low carbon steel, and it changes very little within a large temperature range (Corbacho et al. 1998; Park et al. 2011; Zhao et al. 2015; Qiu et al. 2016). With the increase in demand for natural gas, the liquefied natural gas (LNG) carrier has been developed rapidly as a means of long-distance transport. The material of primary and secondary barriers on the containment insulation system of membrane-type LNG carrier is welded Invar alloy with a thickness of .7 mm, which directly contacts the — 163°C LNG (American Bureau of Shipping 2006; Bureau Veritas 2011; Wang et al. 2006). The total weld length of Invar alloy on an LNG carrier over 13 million cubic meters can reach up to 100 km according to statistics.
Hot cracking is the major problem in the welding of Invar alloy, and currently Tungsten inert gas (TIG) arc welding is commonly used. However, the problem of hot cracking cannot be solved completely, and requires that the operator have good technical knowledge. Invar alloy has high hot cracking susceptibility during the welding process because of its single-phase austenite structure and high content of Ni (Kou 2003). Studies show that the welding hot cracking susceptibility of Invar alloy can be reduced when elements such as Ti, Mn, and Mo are added (Hirata et al. 2001), but these alloying elements will increase the linear expansion coefficient of the weld, resulting in the deterioration of mechanical properties at low temperature. Thus, laser welding and friction stir welding are proposed by researchers to solve the welding hot cracking problem of Invar alloy from the aspect of reducing welding heat input.
Cyber Aggression and Suicidal Ideation in Emerging Adults: Examining the Potential Roles of Depressive Symptoms and Nonsuicidal Self‐Injury
Authors: Liu Luming , Wu Xinchun , Wang Wenchao 
Published: November 2024

ABSTRACTCyber aggression is prevalent among emerging adults and is associated with a range of mental and behavioral issues. One particularly concerning outcome is the widespread presence of suicidal ideation in this group, which poses a significant threat to their life. However, the specific impact of cyber aggression on suicidal ideation and the longitudinal mechanisms remains unclear. Hence, this study sought to address these gaps by applying the general aggression model (GAM). The investigation utilized three‐wave longitudinal data with 6‐month intervals from a large sample of Chinese emerging adults (N = 1568; 54.7% female; Mage = 19.70 [SD = 1.44], ranging from 17 to 26 years). The random‐intercept cross‐lagged panel model (RI‐CLPM) was employed to explore the roles of depressive symptoms and nonsuicidal self‐injury (NSSI) between cyber aggression and suicidal ideation at both the between‐ and within‐person levels. The findings indicated that, at the between‐person level, there were trait‐like associations between depressive symptoms and cyber aggression, NSSI, and suicidal ideation. At the within‐person level, cyber aggression exhibited unidirectional positive cross‐lagged effects on depressive symptoms and NSSI, and could subsequently indirectly lead to suicidal ideation via the contemporaneous associations from depressive symptoms and NSSI to suicidal ideation. These results not only align with GAM but also shed light on the underlying mechanisms linking cyber aggression to suicidal ideation. Also, the findings underscore the significance of maintaining a positive network environment for the well‐being of all internet users even cyber aggression perpetrators.
Commonalities and Characteristics Analysis of Fluorine and Iodine used in Lithium‐Based Batteries
Authors: Gao Lu , Liu Xia , Li Lei , Deng Nanping , Kang Weimin , Cheng Bowen 
Published: November 2024

AbstractAmong optimization strategies for solving the poor ion transport ability and electrolyte/electrode interface compatibility problems of lithium (Li)‐based batteries, halogen elements, such as fluorine (F) and iodine (I), have gradually occupied an important position because of their superb electronegativity, oxidizability, ionic radius, and other properties. The study commences by outlining the shared mechanism by which F and I enhance solid‐state lithium metal batteries' electrochemical performance. In particular, F and I can considerably improve ion transport capacity through chemical means such as intermolecular interactions and halogenation reactions. Furthermore, the utilization of F and I significantly enhances the stability of the electrolyte/electrode interface via physical strategies, encompassing doping techniques, the application of surface coatings, and the fabrication of synthetic intermediate layers. Subsequently, the characteristics of F and I used in Li‐based batteries are elaborated in detail, focusing on the fact that F can provide additional energy density as an anode material but by different mechanisms. Additionally, I can considerably activate dead lithium at the negative electrode, and F can act as a new carrier. Finally, a rational concept of the synergistic effect of F and I is proposed and the feasibility of F–I bihalide solid electrolytes is explored.
PDA‐Ag/TiO2 Nanoparticles‐Loaded Electrospun Nylon Composite Nanofibrous Film‐Based Triboelectric Nanogenerators for Wearable Biomechanical Energy Harvesting and Multifunctional Sensors
Authors: Manchi Punnarao , Paranjape Mandar Vasant , Kurakula Anand , Graham Sontyana Adonijah , Kavarthapu Venkata Siva , Yu Jae Su 
Published: November 2024

AbstractAlthough the adoption of self‐powered energy harvesting technologies is rapidly increasing, the fabrication of flexible, easy‐to‐assemble, highly sensitive, and energy‐efficient devices continues to pose a significant challenge. Electrospun nanofibrous film‐based triboelectric nanogenerators (TENGs) show great promise for mechanical energy harvesting and self‐powered sensor applications due to their flexibility, wearability, lightweight, and high electrical output. Herein, a polydopamine (PDA)‐treated silver (Ag) nanoparticles (NPs)‐decorated titanium dioxide (PDA‐Ag/TiO2 NPs) is innovatively incorporated into an electrospun Nylon 66 polymer to construct PDA‐Ag/TiO2 nylon composite nanofibrous film (NCNF)‐based TENGs (PAT@NCNF TENGs). The prepared nanofibrous films display high dielectric and conductive properties, improving the output electrical performance of the TENG. The electrical output performance of the PAT@NCNF TENG is systematically studied by varying the filler material embedded in the Nylon 66 polymer. The assembled PAT@NCNF TENG exhibits an electrical output of ≈370 V, ≈15 µA, and ≈5.4 W m−2 with an excellent pressure sensitivity of ≈7.88 V kPa−1. The proposed PAT@NCNF TENG is used to harvest various forms of biomechanical energy and to power electronic gadgets. Finally, PAT@NCNF TENG is effectively employed for multifunctional sensing systems to monitor biomechanical actions, detect the pressure and impact of objects, and facilitate Morse code transmission and human gait monitoring applications.
Two Birds with One Stone: Self‐Supporting Anodes and Cathodes for Quasi‐Solid‐State Asymmetric Supercapacitors via Reactions of 2‐Thiobarbituric Acid with Fe and Co Foams
Authors: Ren Jun , Xiang Qian , Yang Chunming , Yang Sufang , Liang Yun , Liu Jinlong , Li Junhua , Qian Dong , Waterhouse Geoffrey I. N. 
Published: November 2024

AbstractAdvanced electrode materials with simple manufacturing processes and wide voltage windows are needed for the commercialization of high energy density supercapacitors. Herein, a facile method is presented for fabricating self‐supporting anodes and cathodes for quasi‐solid‐state asymmetric supercapacitors (QASCs) by hydrothermally reacting 2‐thiobarbituric acid (TBA) with Fe foam (IF) and Co foam (CF), yielding FeTBA4/FeOOH/IF and Co9S8/CF electrodes, respectively. Due to the perfect match between the two electrodes, the redox‐active TBA ligands in FeTBA4, the 2D ultrathin nanosheet structure of FeTBA4/FeOOH/IF, and multiple pairs of reversible redox reactions for suppressing water splitting, the configured Co9S8/CF//FeTBA4/FeOOH/IF QASC device delivers outstanding performance. The device possesses a wide operating voltage window of 1.6 V, leading to a high energy density of 82.64 Wh kg−1 at 486.38 W kg−1 and an equally impressive 35.36 Wh kg−1 at 4595.92 W kg−1. Furthermore, a 98.5% capacitance retention is realized after 10000 charging–discharging cycles. Impressively, density functional theory (DFT) calculations reveal the unique pseudocapacitive reactions on the surface of Co9S8/CF and FeTBA4/FeOOH/IF electrodes. Importantly, this work guides the development of high‐energy‐density supercapacitors via the matching of electrodes and the use of redox‐active complex electrodes.
Local Chemical Enhancement and Gating of Organic Coordinated Ionic‐Electronic Transport
Authors: Khan Tamanna , McAfee Terry , Ferron Thomas J. , Alotaibi Awwad , Collins Brian A. 
Published: November 2024

AbstractSuperior properties in organic mixed ionic‐electronic conductors (OMIECs) over inorganic counterparts have inspired intense interest in biosensing, soft‐robotics, neuromorphic computing, and smart medicine. However, slow ion transport relative to charge transport in these materials is a limiting factor. Here, it is demonstrated that hydrophilic molecules local to an interfacial OMIEC nanochannel can accelerate ion transport with ion mobilities surpassing electrophoretic transport by more than an order of magnitude. Furthermore, ion access to this interfacial channel can be gated through local surface energy. This mechanism is applied in a novel sensing device, which electronically detects and characterizes chemical reaction dynamics local to the buried channel. The ability to enhance ion transport at the nanoscale in OMIECs as well as govern ion transport through local chemical signaling enables new functionalities for printable, stretchable, and biocompatible mixed conduction devices.
Osteoblast‐Derived ECM1 Promotes Anti‐Androgen Resistance in Bone Metastatic Prostate Cancer
Authors: Wang Xinwen , Wang Min , Lin Qijun , He Lixin , Zhang Baolin , Chen Xin , Chen Guanhong , Du Hong , Lang Chuandong , Peng Xinsheng , Dai Yuhu 
Published: November 2024

AbstractAcquired resistance to hormonal therapy, particularly enzalutamide (ENZ), remains a significant obstacle in the treatment of advanced bone metastatic prostate cancer. Here, it is demonstrated that under ENZ treatment, osteoblasts in the bone microenvironment secrete increased levels of extracellular matrix protein 1 (ECM1), which affects surrounding prostate cancer cells, promoting tumor cell proliferation and anti‐androgen resistance. Mechanistically, ECM1 interacts with the enolase 1 (ENO1) receptor on the prostate cancer cell membrane, leading to its phosphorylation at the Y189 site. This event further recruits adapter proteins including growth factor receptor‐bound protein 2 (GRB2) and son of sevenless homolog 1 (SOS1), which activates the downstream mitogen‐activated protein kinase (MAPK) signaling pathway to induce anti‐androgen resistance. Furthermore, inhibiting ECM1 or utilizing the ENO1‐targeting inhibitor phosphonoacetohydroxamate (PhAH) significantly restores tumor cell sensitivity to ENZ. Taken together, a potential mechanism is identified through which osteoblast‐derived ECM1 drives resistance in bone metastatic prostate cancer under ENZ treatment. Additionally, the findings indicate that ECM1 and ENO1 may serve as potential targets for developing therapies for bone metastatic castration‐resistant prostate cancer.
Electro‐Chemo‐Mechanical Degradation in Solid‐State Batteries: A Review of Microscale and Multiphysics Modeling
Authors: De Gol Anna , Dermenci Kamil Burak , Farkas Laszlo , Berecibar Maitane 
Published: November 2024

AbstractSolid‐state batteries with lithium‐metal anodes have emerged as a promising alternative to traditional lithium‐ion batteries thanks to their enhanced energy density and safety. However, the integration of solid‐state electrolytes is still hindered by mechanical instabilities caused by the rigid nature of the system. Stress and strain can be transferred at the interface between electrodes and solid electrolyte, inducing material damage during cycling. To address this issue, a comprehensive understanding of the interplay between electrochemical reactions and mechanical effects is crucial. In this article, a critical review of various approaches to model the multiphysics behavior of Li‐metal solid‐state batteries is provided by analyzing their advancements and limitations. The focus lies on workflows which simulate the effect of microstructural and material property changes on the degradation processes. Continuum modeling of three key chemo‐mechanical challenges is explored: dendritic growth from Li‐metal anodes, structural instability in composite cathodes, and solid electrolyte degradation caused by the formation of unstable interphases. The conclusion highlights the existing challenges and upcoming trends in multiphysics and microscale modeling of batteries.
The Electrochemical Acetone/Isopropanol Hydrogenation Cycle – An Alternative to Current Hydrogen Storage Solutions
Authors: Venus Dominik , Marth Axel , Riess Sebastian , Freiberg Anna T.S. , Brodt Matthew , Wensing Michael , Wasserscheid Peter , Thiele Simon 
Published: November 2024

AbstractLiquid organic hydrogen carrier (LOHC) systems offer a promising way to store hydrogen using the existing infrastructure for liquid fuels. While LOHC hydrogenation and dehydrogenation processes have so far mainly been investigated using thermocatalytic processes, this work explores the concept of a low‐temperature (<80 °C) electrochemical acetone/isopropanol LOHC cycle and indicates its potential benefits for a future hydrogen economy. This electrochemical liquid organic hydrogen carrier (EC‐LOHC) system builds on low‐cost chemicals with low ecotoxicology. In this study, the influence of temperature and fuel concentrations on the polarization curves of the electrochemical hydrogenation and dehydrogenation units in a small, single‐cell set‐up is investigated using proton exchange membrane fuel cell components. Based on the experimental results, efficiencies are determined for a power‐to‐power cycle that can be competitive to mature hydrogen storage technologies, such as liquid and compressed hydrogen storage. Finally, material‐related challenges are discussed, encouraging future research in this new field of hydrogen storage.
Prognostic significance of mutation type and chromosome fragility in Fanconi anemia
Authors: Ramírez María José , Pujol Roser , Minguillón Jordi , Bogliolo Massimo , Persico Ilaria , Cavero Debora , de la Cal Aurora , Río Paula , Navarro Susana , Casado José Antonio , Bailador Almudena , de la Fuente Antonio Sanchez , de Heredia Miguel López , Almazán Francisco , Antelo M. Luisa , Argilés Bienvenida , Badell Isabel , Baragaño Marta , Beléndez Cristina , Bermúdez Mar , Bernués Marta , Buedo María Isabel , Carrasco Estela , Català Albert , Costa Dolors , Cuesta Isabel , Fernandez‐Delgado Rafael , Fernández‐Teijeiro Ana , Figuera Ángela , García Marta , Gondra Ainhoa , González Macarena , Muñiz Soledad González , Hernández‐Rodríguez Ines , Ibañez Fátima , Kelleher Nicholas John , Lendínez Francisco , López Mónica , López‐Almaraz Ricardo , Marchante Inmaculada , Mendoza Carmen , Nieto José , Ojeda Emilio , Payán‐Pernía Salvador , Peláez Irene , de Soto Inmaculada Pérez , Portugal Raquel , Ramos‐Arroyo María A. , Regueiro Alexandra , Rodríguez Ana , Rosell Jordi , Saez Raquel , Sánchez José , Sánchez Martha , Senent MªLeonor , Tapia María , Trujillo‐Quintero Juan Pablo , Vagace José Manuel , Verdú‐Amorós Jaime , Verdugo Victória , Vidales Isabel , Villarreal Jasson , Díaz‐de‐Heredia Cristina , Sevilla Julián , Bueren Juan Antonio , Surrallés Jordi 
Published: November 2024

AbstractFanconi anemia (FA) is a rare genetic disease characterized by high phenotypic and genotypic heterogeneity, and extreme chromosome fragility. To better understand the natural history of FA, identify genetic risk and prognostic factors, and develop novel therapeutic strategies, the Spanish Registry of Patients with FA collects data on clinical features, chromosome fragility, genetic subtypes, and DNA sequencing with informed consent of participating individuals. In this article, we describe the clinical evolution of 227 patients followed up for up to 30 years, for whom our data indicate a cumulative cancer incidence of 86% by age 50. We found that patients with lower chromosome fragility had a milder malformation spectrum and better outcomes in terms of later‐onset hematologic impairment, less severe bone marrow failure, and lower cancer risk. We also found that outcomes were better for patients with mutations leading to mutant FANCA protein expression (genetic hypomorphism) than for patients lacking this protein. Likewise, prognosis was consistently better for patients with biallelic mutations in FANCD2 (mainly hypomorphic mutations) than for patients with biallelic mutations in FANCA and FANCG, with the lack of the mutant protein in patients with biallelic mutations in FANCG contributing to their poorer outcomes. Our results regarding the clinical impact of chromosome fragility and genetic hypomorphism suggest that mutant FA proteins retain residual activity. This finding should encourage the development of novel therapeutic strategies aimed at partially or fully enhancing mutant FA function, thereby preventing or delaying bone marrow failure and cancer in patients with FA.Clinical Trial Registration number: NCT06490510.
Different impacts of granulocyte colony‐stimulating factor administration on allogeneic hematopoietic cell transplant outcomes for adult acute myeloid leukemia according to graft type
Authors: Konuma Takaaki , Kameda Kazuaki , Morita Kaoru , Kondo Tadakazu , Kimura Fumihiko , Nakasone Hideki , Ouchi Fumihiko , Uchida Naoyuki , Tanaka Masatsugu , Nishida Tetsuya , Fukuda Takahiro , Hasegawa Yuta , Sakata‐Yanagimoto Mamiko , Onizuka Makoto , Sawa Masashi , Ota Shuichi , Asada Noboru , Fujiwara Shin‐Ichiro , Yoshihara Satoshi , Ishimaru Fumihiko , Yoshimitsu Makoto , Kanda Yoshinobu , Ohbiki Marie , Atsuta Yoshiko , Yanada Masamitsu 
Published: November 2024

AbstractWe retrospectively evaluated the impacts of using granulocyte colony‐stimulating factor (G‐CSF) and its timing on posttransplant outcomes for 9766 adults with acute myeloid leukemia (AML) between 2013 and 2022 using a Japanese database. We separately evaluated three distinct cohorts based on graft type: 3248 received bone marrow transplantation (BMT), 3066 received peripheral blood stem cell transplantation (PBSCT), and 3452 received single‐unit cord blood transplantation (CBT). Multivariate analysis showed that G‐CSF administration significantly accelerated neutrophil recovery after BMT, PBSCT, and CBT. However, it was associated with a higher risk of grades II–IV acute graft‐versus‐host disease (GVHD) across all graft types. Moreover, an increased incidence of overall chronic GVHD was observed with G‐CSF administration in BMT and CBT patients, but not in PBSCT patients. G‐CSF administration significantly improved overall survival (OS) and leukemia‐free survival (LFS) only following CBT. Regarding the timing of G‐CSF, in comparison with late initiation of G‐CSF (Days 5–10), early initiation (Days 0–4) did not provide benefits for hematopoietic recovery regardless of graft type. In contrast, late initiation was significantly associated with a lower risk of grades II–IV acute GVHD and better OS and LFS in CBT patients. These data demonstrated that G‐CSF administration accelerated neutrophil recovery and increased the risk of grades II–IV acute GVHD across all graft types, but significantly improved survival outcomes but only following CBT. Therefore, routine use of G‐CSF should be considered for CBT in adult patients with AML.
Efficacy and Safety of Sodium Oxybate in Isolated Focal Laryngeal Dystonia: A Phase IIb Double‐Blind Placebo‐Controlled Cross‐Over Randomized Clinical Trial
Authors: Simonyan Kristina , O'Flynn Lena C. , Hamzehei Sichani Azadeh , Frucht Steven J. , Rumbach Anna F. , Sharma Nutan , Song Phillip C. , Worthley Alexis 
Published: November 2024

ObjectiveTo examine the efficacy and safety of sodium oxybate versus placebo in a phase IIb randomized double‐blind placebo‐controlled 2‐period cross‐over clinical trial in patients with isolated laryngeal dystonia (LD).MethodsThe study was conducted from January 2018 to December 2021, pausing during the COVID‐19 pandemic, at Massachusetts Eye and Ear in 106 patients with alcohol‐responsive (EtOH+) and alcohol‐non‐responsive (EtOH−) LD (53 to receive 1.5g of sodium oxybate first, 53 to receive matching placebo first). The primary outcome was a change from baseline in LD symptom severity 40 minutes after drug intake. Safety was based on vital signs, cognitive function, suicidality, daytime sleepiness, and adverse events. Patients, investigators, and outcome assessors were masked to study procedures.ResultsCompared to baseline, EtOH+ but not EtOH− patients had a statistically significant improvement in LD symptoms following sodium oxybate versus placebo (EtOH+: 98.75% confidence interval [CI] = 0.6–26.9; p = 0.008; EtOH−: 98.75% CI = −6.2 to 18.7; p = 0.42). Statistically significant minimum drug efficacy in EtOH+ patients was found at ≥16% symptom improvement (OR = 2.09; 98.75% CI = 0.75–5.80; p = 0.036), with an average of 40.81% benefits (98.75% CI = 34.7–48.6). Drug efficacy waned by 300 minutes after intake without a rebound. No changes were found in cognitive function, suicidality, or vital signs. Common adverse events included mild dizziness, nausea, and daytime sleepiness.InterpretationSodium oxybate showed clinically meaningful improvement of symptoms in EtOH+ LD patients, with acceptable tolerability. Sodium oxybate offers the first pathophysiologically relevant oral treatment for laryngeal dystonia. ANN NEUROL 2025;97:329–343