bluuebunny/crossref_metadata_2025_split huggingface dataset:
New species and a new genus of the Orthoseirales from Patagonia, Argentina, with comments on systematic affinities within the Order
Authors: GUERRERO J.M. , VOUILLOUD A.A , SALA S.E. , KOCIOLEK J.P. , VAN DE VIJVER B. 
Published: March 2018

The presence of ‘carinoportulae’ was suggested to be diagnostic for the Order Orthoseirales and Family Orthoseiraceae. Members of this group have been assigned to a single genus, Orthoseira Thwaites, which was diagnosed by also lacking rimoportulae. The genus Cavernosa Stidolph is chain-forming, may have marginal spines, lacks carinoportulae and possesses rimoportulae. Its placement among other members of melosiroid diatoms has not been settled, though its lack of carinoportulae precludes its placement within the Orthoseirales. Species of both genera were described from aerophilous habitats. Recently Orthoseira limnopolarensis Van de Vijver and Crawford was described from the South Shetland Islands (maritime region of Antarctica) with a unique combination of features, as it possesses carinoportulae and rimoportulae, the first species of the genus with this suite of characters. Cyclotella stipata Frenguelli, described from Neuquén Province, Argentina, is a species that according to the original illustrations shows characters similar to Orthoseira. Light and electron microscope observations of Frenguelli´s type material and more recent collections from Patagonia offer specimens with an elongated mantle, chain-forming frustules with thick marginal spines and presence of carinoportulae (like Orthoseira) and rimoportulae (like Cavernosa and O. limnopolarensis). Considering this unique combination of characters, we propose the new genus Guarreraea to encompass Cyclotella stipata and Orthoseira limnopolarensis. Its systematic placement relative to other genera assigned to the Order Orthoseirales is discussed. The examination of additional materials from Neuquén deposited at the Frenguelli Collection revealed the presence of two other taxa with carinoportulae that are described as the new species, Orthoseira frenguellii and O. ferrarioana.
Meeting my child for the first time: adoptive parents’ experiences of the period of adoption transition
Authors: Lewis Lisa 
Published: March 2018

This article presents findings from a small-scale qualitative research study exploring the experiences of adoptive parents during adoption transitions – the time between when a match with a child is made until a number of months after placement. What happens during this period can have a bearing on the future success of the placement and long-term well-being of the child. The article seeks to explore the experiences of adoptive parents during this stage of the process in order for practitioners to become better informed about what can make transitions successful. Semi-structured interviews were conducted with nine parents to capture the narrative of their adoption transition experience. Thematic analysis of the conversations revealed five main themes: rigidity, scrutiny, support, overall reflections and the relationship with the foster carer. The findings suggest that the transition period was a significant but problematic stage in the adopters’ overall adoption journey. Considerable inconsistency in the approach taken to practice in this area affected their experiences. The research highlighted areas of practice which are out of sync with that recommended in the literature; the article concludes with recommendations for promoting consistency.
Predictors of Clinical Outcomes After Hip Arthroscopy: A Prospective Analysis of 1038 Patients With 2-Year Follow-up
Authors: Domb Benjamin G. , Martin Timothy J. , Gui Chengcheng , Chandrasekaran Sivashankar , Suarez-Ahedo Carlos , Lodhia Parth 
Published: March 2018

Background: As hip arthroscopy has expanded in popularity and volume, more information is needed about indications for the procedure and the predictive factors of clinical outcomes. Purpose: To evaluate clinical outcomes of hip arthroscopy in a prospective study and to analyze the cohort to identify factors that are predictive of improvement. Study Design: Case-control study; Level of evidence, 3. Methods: Data were collected prospectively on all patients undergoing hip arthroscopy between February 2008 and June 2012. We included all patients undergoing hip arthroscopy who agreed to participate and who completed 4 patient-reported outcome (PRO) instruments at a minimum 2-year follow-up: the modified Harris Hip Score (mHHS), Nonarthritic Hip Score (NAHS), Hip Outcome Score–Activities of Daily Living (HOS-ADL), and Hip Outcome Score–Sport-Specific Subscale. The NAHS was selected as our primary outcome instrument. All patients with any previous hip conditions were excluded. We analyzed 34 preoperative and intraoperative variables using bivariate and multivariate analyses compared with NAHS. Results: The cohort consisted of 1038 patients with a mean follow-up of 30.1 months (range, 24.0-61.2 months). Mean age was 36.4 years (range, 13.2-76.4 years). All postoperative PRO scores showed significant improvement ( P < .001) at 2 years compared with preoperative scores. Bivariate analysis identified 15 variables (7 categorical and 8 continuous) and multivariate analysis identified 10 variables that were predictive of 2-year postoperative NAHS. Preoperative NAHS, preoperative HOS-ADL, preoperative mHHS, age, duration of symptoms, body mass index (BMI), and revision hip arthroscopy were identified as predictive factors in both bivariate and multivariate analyses. The predictive value of preoperative NAHS was accentuated for patients with higher BMI. Conclusion: This study reports favorable clinical outcomes in the largest cohort of hip arthroscopies with a minimum 2-year follow-up in the literature to date. Factors identified as predictive in both bivariate and multivariate analyses included preoperative NAHS, HOS-ADL, and mHHS; age; duration of symptoms; BMI; and revision hip arthroscopy. These predictive factors may be useful to the clinician in determining prognosis and operative indications for hip arthroscopy.
Efficacy and Safety of Basal Insulin/GLP-1 Receptor Agonist Used in Combination for Type 2 Diabetes Management
Authors: McCarty Delilah , Olenik Alaina , McCarty Bryan P. 
Published: March 2018

Purpose: The purpose of this article is to review the efficacy, safety, and place in therapy of insulin degludec/liraglutide (IDegLira) and insulin glargine/lixisenatide (IGlarLixi) in the treatment of type 2 diabetes mellitus. Summary: Type 2 diabetes is a condition affecting nearly 30 million American adults. Management of type 2 diabetes is complex and multifactorial. Using medications targeted at a variety of the physiologic defects known to contribute to the development of type 2 diabetes allows for a patient-specific approach to care. Utilizing combination products is a way to target several areas of the disease while decreasing the complexity and burden to the patient. Basal insulin/glucagon-like peptide-1 (GLP-1) agonist combination products have the benefit of being highly efficacious while having favorable effects on weight, reduced gastrointestinal adverse effects, and low hypoglycemic risks compared to the individual agents used alone. Conclusion: This article will review 2 basal insulin/GLP-1 agonist combination products, IDegLira and IGlarLixi, which were approved in November 2016.
#CleftProud
Authors: Stock Nicola Marie , Martindale Anna , Cunniffe Claire 
Published: March 2018

Background: More than 2 billion people worldwide now use social networking sites, with an increasing number of users accessing these sites to obtain health information and engage in emotional support. Yet, investigation of social networking sites in the context of cleft lip and/or palate (CL/P) has been scarce. Methods: Real-time data posted during 2 weeks in April 2017 were collected from 2 existing private Facebook groups (hosted by the Cleft Lip and Palate Association United Kingdom) using video screen capture software. The number of posts, comments, unique contributors, and post “likes” was recorded, as well as the type and theme of each post. Data relating to the benefits and challenges of participation in the 2 groups were also collected via an online survey. Results: A content analysis of real-time data identified perioperative care, associated syndromes, and dental health to be particular areas of concern for parents/caregivers. Expectations, experiences, and outcomes of further treatment were key topics of discussion for adults with CL/P. Common benefits of the groups included the ability to connect with others, learn about local events, give and receive emotional support, and obtain quick responses to queries in a semi-anonymous environment. Disadvantages of the groups included a reliance upon opinion rather than medical fact and the frequent use of inappropriate terminology. Conclusions: Social networking sites appear to be a helpful source of health-related information and peer support for the CL/P population, yet closer monitoring of these groups may be required.
Evaluation of hyaloid–retinal relationship during triamcinolone-assisted vitrectomy for primary rhegmatogenous retinal detachment
Authors: Sundar Dheepak , Takkar Brijesh , Venkatesh Pradeep , Chawla Rohan , Temkar Shreyas , Azad Shorya Vardhan , Vohra Rajpal 
Published: March 2018

Aims: To determine hyaloid–retinal relationship in primary rhegmatogenous retinal detachment during vitreous surgery. Methods: This is a prospective, interventional study of patients (n = 72) undergoing triamcinolone-assisted 25G vitreous surgery for primary rhegmatogenous retinal detachment. Hyaloid–retinal relationship was noted intraoperatively to identify regions and patterns of firm attachment and was classified into subgroups. Analysis was done to determine association between hyaloid–retinal relationship patterns and preoperative findings: posterior vitreous detachment, proliferative vitreoretinopathy, type of retinal tear, the presence of peripheral degenerations, and postoperative outcomes. Results: Three patterns of hyaloid–retinal relationship were identified: type1 (complete absence of posterior vitreous detachment (21%)), type 2 (incomplete posterior vitreous detachment (47%)) and type 3 (complete posterior vitreous detachment (32%)). Posterior vitreous detachment in some form was present in 84% of the cases with retinal tears as the causative break but none of the cases with retinal holes (p < 0.001). None of the cases with vitreoretinal degeneration had complete posterior vitreous detachment (p = 0.001). 69% of proliferative vitreoretinopathy–C cases had type 1 hyaloid–retinal relationship as compared to 11% cases with no proliferative vitreoretinopathy (p < 0.001). Proliferative vitreoretinopathy-related anatomical failure was seen in 7.5%, and 80% of these eyes with recurrent RD had type 1 hyaloid–retinal relationship (p<0.001). Nearly half the patients diagnosed as complete posterior vitreous detachment preoperatively were found to have incomplete posterior vitreous detachment intraoperatively. Conclusions: Majority of the cases with rhegmatogenous retinal detachment have some form of strong vitreoretinal adhesion. Hyaloid–retinal relationship varies with types of retinal breaks, retinal degeneration, and proliferative vitreoretinopathy. Intraoperative hyaloid–retinal relationship is frequently different from that assessed before surgery and the proposed classification may improve surgical decision making and prognostication.
Hypnosis as adjunct therapy to conscious sedation for venous access device implantation in breast cancer: A pilot study
Authors: Sterkers Nicolas , Chabrol Jean L , De Troyer Jeremy , Bonijol Dany , Darmon Jean C , Donnez Olivier 
Published: March 2018

Background: Recent reviews support that hypnosis has great potential for reducing pain and anxiety during mini-invasive surgery. Here, we assessed the feasibility of hypnotic induction session as adjunct therapy in conscious sedation for venous access device implantation. Primary outcomes were safety and patient satisfaction. Methods: Thirty consecutive women with breast cancer were proposed adjunct of hypnosis before implantation under conscious sedation (midazolam: 0.5 mg ± bolus of Ketamin: 5 mg on demand) indicated for chemotherapy. Self-hypnosis was programmed and guided by one of two trained anesthesiologists. Implantation was performed by one of two experimented surgeons. It consisted of blind subclavian implantation of Braun ST 305 devices using a percutaneous technique adapted from Selinger’s procedure. Clinical data were prospectively collected and retrospectively analyzed. A comprehensive custom-made questionnaire recorded patient satisfaction. Results: In all, 30/30 patients consented to the procedure. The median age was 54 years (range: 35–77 years). The primary procedure was successful in 29/30. One case was converted into internal jugular vein access after a first attempt. Median length time of the implantation procedure in the operative room was 20 min (range: 10–60 min). Median length time in the recovery room preceding home discharge was 65 min (range: 15–185 min). None of the patients suffered complications. The satisfaction rate was ≥90%, 27/30 patients would get hypnosis in case of reimplantation if necessary and 27/30 would recommend this procedure to others. Conclusion: Hypnosis under conscious sedation appears feasible and safe for port implantation under conscious sedation in cancer patients. Further studies would determine the exact value of hypnosis effectiveness.
Prevalence of salivary human herpesviruses in pediatric multiple sclerosis cases and controls
Authors: Leibovitch Emily C , Lin Cheng-Te Major , Billioux Bridgette J , Graves Jennifer , Waubant Emmanuelle , Jacobson Steven 
Published: March 2018

Background: Multiple sclerosis (MS) is a multifactorial disease of unknown origin. The current paradigm is that disease develops in genetically susceptible individuals, influenced by environmental factors. Epstein–Barr virus (EBV) and human herpesvirus 6 (HHV-6) have particularly strong associations with the disease. Both viruses are typically acquired during childhood, decades before MS presents. However, in patients with pediatric MS, the temporal window between viral acquisition and disease onset is shortened, which may provide insights into the association of herpesviruses with MS. Objective: To compare the frequency of EBV and HHV-6 in the saliva of a cohort of pediatric MS patients and age-matched controls. Methods: The study enrolled 32 pediatric MS patients and 42 controls and evaluated saliva for HHV-6 u57 and EBV lmp-1 amplification by droplet digital polymerase chain reaction (ddPCR). Results: Pediatric MS patients did not differ from controls in the frequency or magnitude of salivary viral shedding. During the assessment of EBV positivity, distinct profiles emerged that correlated with target amplicon mutations. Conclusions: None of these mutations were evident in EBV-positive samples from pediatric MS patients, whereas they were present in pediatric controls, in addition to MS and control adults, suggesting differential host-immune control of EBV in this pediatric MS cohort.
Demographics and clinical characteristics of episodic hypothermia in multiple sclerosis
Authors: Toledano Michel , Weinshenker Brian G , Kaufmann Timothy J , Parisi Joseph E , Paz Soldán M Mateo 
Published: March 2018

Background: Episodic hypothermia (EH) can occur in multiple sclerosis (MS). The putative mechanism is impairment of thermoregulation due to a presumed demyelinating hypothalamic lesion. Objective: To describe a cohort of patients with MS, who developed EH. Methods: Patients were identified through review of the Mayo Clinic electronic medical record (1996 to July 2015). Search terms were [multiple sclerosis] or [MS] within the diagnoses field and [hypothermia] within any field. We reviewed records for accuracy of diagnoses and abstracted relevant data. Magnetic resonance imaging (MRI) was reviewed for presence of hypothalamic lesions. Results: Of 156 patients, 34 had concurrent MS and hypothermia. Thirty-two (94%) had progressive disease at EH onset. Median MS duration was 19.9 years, and median expanded disability status scale (EDSS) was 8.0. Most patients presented with alterations in consciousness. Infection was suspected as the precipitating factor in 19 (56%), but clinically/laboratory supported in only 9 (28%). MRI lesions were evident within the hypothalamus in only 4 (14%). Conclusion: EH occurs predominantly in patients with advanced secondary progressive MS. The major manifestation is altered consciousness. Infection is often suspected as causal, but infrequently confirmed. Although commonly implicated, hypothalamic lesions were rarely evident on MRI and were absent in two post-mortem evaluations.
The natural history of type 2 endoleaks after endovascular aneurysm repair justifies conservative management
Authors: Ajalat Mark , Williams Russell , Wilson Samuel E 
Published: March 2018

Objective Management of type 2 endoleaks after endovascular aneurysm repair has been controversial. Some advocate for conservative management, while others believe that intervention is indicated. This study investigated the natural history of type 2 endoleaks in order to derive direction in management. Methods Patients who had endovascular aneurysm repair at the Veterans Affairs Long Beach were retrospectively identified and computerized tomographic angiography was independently reviewed by a radiologist and a vascular surgeon. Type 2 endoleaks were analyzed for the following outcomes: rupture, duration of endoleak, spontaneous resolution, changes in the size of the aneurysm sac, and reintervention rates. Results Of the 160 patients who had completed required follow-up to date (mean 3 years) after endovascular aneurysm repair, 39 (24.4%) patients were identified as having a type 2 endoleak on computerized tomographic angiography imaging. 6 (15.4%) of these 39 patients required repair due to aneurysm sac growth >1 cm. 2 (5.13%) were repaired with an open procedure and 4 (10.3%) with an endovascular approach. Of these 6 aneurysm leaks requiring repair, 4 (66.7%) had a simultaneous endoleak (types 1 or 3) in addition to the identified type 2 endoleak. Spontaneous resolution of type 2 endoleaks occurred in 16 (41.0%) patients. 4 patients (10.3%) had delayed type 2 endoleaks that presented 4, 9, 12, and 23 months after their 30 day post op computed tomography was normal. None of the 4 patients with delayed type 2 endoleaks required reintervention and none had aneurysm sac growth greater than 5 mm. Conclusions Overall, we found that 85% of patients who had type 2 endoleaks did not require intervention after a mean follow-up time of 3 years. The association of a type 1 or 3 endoleak with a type 2 endoleak was more likely to require correction due to aneurysm expansion >1 cm, thus type 2 endoleaks associated with another type of endoleak require more aggressive management.
A kindergarten-based child health promotion program: the Adapted National Aeronautics and Space Administration (NASA) Mission X for improving physical fitness in South Korea
Authors: Min Jungwon , Kim Gilsook , Lim Hyunjung , Carvajal Nubia A. , Lloyd Charles W. , Wang Youfa 
Published: March 2018

Background: Effective and sustainable intervention programs are needed to promote physical activity (PA) in children. Objectives: To adapt the NASA Mission X: Train Like an Astronaut program for use with South Korean children, and to evaluate its feasibility and effectiveness for promoting children’s physical fitness. Methods: Children 5 years old ( n = 212) and their parents were recruited from three kindergartens in three cities to participate in a 6-week intervention program in fall 2014. We assessed the children’s PA and related changes, and parental changes in attitude and beliefs, after participation in the intervention. Results: Girls reported less PA than boys (40.7 vs. 59.0, p < 0.01). Children with a normal body mass index (BMI) were more likely to be active than underweight children (< 10 percentile) or overweight children (⩾ 85 percentile). After the intervention, about one-half of the children had increased their level of PA (49.4%), increased interest in PA (59.1%) and found psychological need satisfaction in exercise (52.6%). The majority of parents became aware of the necessity of childhood PA (94.2%), their child’s PA capability (64.3%), and the relationship of PA with their children’s self-esteem (79.9%). Conclusions: The adapted NASA Mission X program was feasible and effective in promoting PA in kindergarteners, and also improved their parents’ attitude and beliefs about children’s PA in South Korea. This study provided a model for promoting childhood health through child care and educational settings.
Perceived Benefits and Challenges of a Risk-Based Approach to Multidisciplinary Chronic Kidney Disease Care: A Qualitative Descriptive Study
Authors: Smekal Michelle D. , Tam-Tham Helen , Finlay Juli , Donald Maoliosa , Benterud Eleanor , Thomas Chandra , Quinn Robert R. , Tam Kin , Manns Braden J. , Tonelli Marcello , Bello Aminu , Tangri Navdeep , Hemmelgarn Brenda R. 
Published: March 2018

Background: The kidney failure risk equation (KFRE) provides an estimate of risk of progression to kidney failure, and may guide clinical care. Objective: We aimed to describe patient, family, and health care provider’s perspectives of the perceived benefits and challenges of using a risk-based approach to guide care delivery for patients with advanced chronic kidney disease (CKD), and refine implementation based on their input. Methods: We used qualitative methodology to explore perceived benefits and challenges of implementing a risk-based approach (using the KFRE) to determine eligibility for multidisciplinary CKD care in Southern Alberta. We obtained perspectives from patients and families through focus groups, as well as input from health care providers through interviews and open-ended responses from an online survey. Twelve patients/family members participated in 2 focus groups, 16 health care providers participated in an interview, and 40 health care providers responded to the survey. Results: Overall, participants felt that a KFRE-based approach had the potential to improve efficiency of the clinics by targeting care to patients at highest risk of kidney failure; however, they also expressed concerns about the impact of loss of services for lower risk individuals. Participants also articulated concerns about a perceived lack of capacity for adequate CKD patient care in the community. Our implementation strategy was modified as a result of participants’ feedback. Conclusions: We identified benefits and challenges to implementation of a risk-based approach to guide care of patients with advanced CKD. Based on these results, our implementation strategy has been modified by removing the category of referral back to primary care alone, and instead having that decision made jointly by nephrologists and patients among low-risk patients.