bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE HARDER THEY FALL: THE WORKINGS OF POLICE PROCEDURAL DRAMA IN LINE OF DUTY AND BETWEEN THE LINES
Authors: Geraghty Christine 
Published: November 2024

On 2nd May 2021, on a Sunday night, the BBC serial Line of Duty (2012-) ended its 6th series in a finale which was watched by an average of 12.8 million viewers a record for the World Productions-produced BBC police corruption drama.
5G Internet of Things (IoT) And Its Impact to Agricultural Technology: Basis for Strategic Plan
Authors: Li Xiaopeng , Aquino Jet 
Published: November 2024

This study explored the integration and impact of 5G-enabled Internet of Things (IoT) technology in agricultural practices in Hainan Province, China, through a quantitative descriptive approach. The study encompasses responses from the participants, including farm managers, agricultural technology experts, and farm owners. It delves into the demographic and professional profiles of these respondents, revealing a majority in the 35-44 age group, predominantly female, with a significant number holding college degrees or higher and mostly farm owners. The impact of 5G-enabled IoT on agricultural technology is generally perceived positively by respondents. The shared understanding of 5G's potential positive influence on agricultural productivity, compatibility with existing setups, and operational performance underscores the transformative capabilities of this technology. However, the study also identifies challenges, including concerns regarding cost effectiveness, accuracy, and risk/security, which pose significant hurdles to the widespread adoption of these technologies. The proposed strategic plan suggests targeted outreach, awareness programs, and the development of innovative financing models and cybersecurity measures to foster a conducive environment for the adoption of 5G IoT in agriculture. In conclusion, the study provides insights into the current perception and impact of 5G-enabled IoT in agriculture, coupled with actionable recommendations to navigate the challenges and maximize the technology's potential benefits. This comprehensive approach aims to support stakeholders in the agricultural sector in leveraging 5G IoT for enhanced productivity and sustainability.
อิทธิพลของสมรรถนะผู้ดูแลผู้สูงอายุและกลยุทธ์การสร้าง ความได้เปรียบในการแข่งขันที่มีต่อผลการดำเนินงานของธุรกิจการดูแลผู้สูงอายุ ในเขตกรุงเทพมหานคร
Authors: สอนผึ้ง สำราญ , นุริตมนต์ วสุธิดา 
Published: November 2024

งานวิจัยนี้มีวัตถุประสงค์เพื่อศึกษาอิทธิพลของสมรรถนะผู้ดูแลผู้สูงอายุ และอิทธิพลของกลยุทธ์การสร้างความได้เปรียบในการแข่งขันที่มีต่อผลการดำเนินงานของธุรกิจการดูแลผู้สูงอายุในเขตกรุงเทพมหานคร กลุ่มตัวอย่างได้แก่ ผู้บริหารของธุรกิจดูแลผู้สูงอายุในเขตกรุงเทพมหานคร จำนวน 288 คน เครื่องมือที่ใช้ในการเก็บรวบรวมข้อมูล ได้แก่ แบบสอบถาม สถิติที่ใช้ในการวิเคราะห์ข้อมูล ได้แก่ ร้อยละ ค่าเฉลี่ย และส่วนเบี่ยงเบนมาตรฐาน และการทดสอบสมมติฐานใช้การวิเคราะห์การถดถอยเชิงพหุคูณ (Multiple regression analysis) ผลการวิจัยพบว่า 1) สมรรถนะของผู้ดูแลผู้สูงอายุ ซึ่งประกอบด้วย ความรู้ ทักษะ และ ทัศนคติและบทบาททางสังคมของผู้ดูแลผู้สูงอายุ ไม่มีอิทธิพลต่อผลการดำเนินงานของธุรกิจการดูแลผู้สูงอายุในเขตกรุงเทพมหานคร และ 2) กลยุทธ์การสร้างความได้เปรียบในการแข่งขัน ซึ่งประกอบด้วย การเป็นผู้นำด้านต้นทุน การสร้างความแตกต่าง และการมุ่งเน้นเฉพาะส่วนของธุรกิจ มีอิทธิพลต่อผลการดำเนินงานของธุรกิจการดูแลผู้สูงอายุในเขตกรุงเทพมหานคร ข้อเสนอแนะสำหรับการวิจัยในครั้งต่อไป ได้แก่ ควรวิจัยเพิ่มเติมในปัจจัยที่เป็นปัจจัยที่มีอิทธิพลต่อผลการดำเนินงานของธุรกิจการดูแลผู้สูงอายุ รวมถึงขยายขอบเขตการวิจัยให้ครอบคลุมภูมิภาคอื่น ๆ ของประเทศไทยด้วย
Essence and Economic Impacts of Food: A Thematic Analysis
Authors: C Uche, , E. N Ajie, 
Published: November 2024

The number of food insecure people may not have changed much despite the global campaigns especially in Africa where for centuries people dined and lived on natural, wild and organic food sources which supported their health and vitality although adjudged crude and inadequate. The West may have attained significant mile stones in food security for a price. Modern (western) food condiments and feeding patterns which the elites in Africa are subscribing to seem to be programmed to impoverish human health and in the process enriching the pharmaceutical industries. The emergence and adoption of western food culture and feeding regimen has heralded the emergence of diseases and sicknesses hitherto little known to most Africans. The basic essence of food is to ensure body growth, repair of and maintenance of body tissues and regulation of vital processes. Any food form that ensures you visit a doctor is poisoning no matter the taste and packaging hence the need for not only food security but also adequacy. Food security is also an important component of economic development and germane to global economic agenda. Food adequacy supports economic and Sustainable Development Goals (SDGs) of any government by enhancing the citizens’ health thus broadening productivity and economic opportunities. This is important because food presently is a big industry globally and can earn big profits and make a difference in the economy because it can impact economic development in many different forms. It can affect health and education and because it plays important roles in health and education, it can plausibly impact economic growth and development especially human capital formation and is a necessary tool to spur economic growth.
Characterization and Classification of Soils of Chamba Block of Tehri Garhwal District of Uttarakhand, India: A Case Study from Lesser Himalayas
Authors: Joon Vikas , Meena Rajesh Kumar , Nagdev Ritu , Surya Jaya N. 
Published: November 2024

In the present study, an attempt was made to characterize and classify the soils occurring on different topography in the Chamba block of Tehri Garhwal district of Uttarakhand. A detailed soil survey was carried out by simple random sampling and studying master profiles using Landscape Ecological Unit’s map on 1:10000 scale to study the soils. The high-resolution remote sensing data product derived from the IRS-R2, specifically the LISS-IV data and GIS approaches were used. Nine representative pedons (covering all the soil types) were studied for their morphological, physical and chemical properties. These soils were very shallow to deep, dark grayish brown to dark brown/dark yellowish brown, brown to dark yellowish brown, dark grayish brown to olive brown and very dark grayish brown to dark yellowish brown in colour. Structure of the surface soils varied from sub-angular blocky to disturbed to single grain.Soil texture varied fromsandy loam to sandy loam, sandy loam to loam, loamy sand to sand and loam to clay loam in texture, strongly acidic to acidic (<5.5-6.5) and neutral (6.5-7.5) in reaction. The electric conductivity exhibited a range from 0.17 to 1.83 dS m-1 within surface horizons and from 0.02 to 0.80 dS m-1 within the sub-surface horizons, accompanied by organic carbon content categorized as medium (0.50-0.75%) to high (>0.75%). The exchangeable cations, specifically Ca2+, Mg2+, Na+, and K+, demonstrated variability ranging from 4.90 to 10.40, 1.30 to 4.00, 0.39 to 1.01, and 0.44 to 1.27 cmol p+kg-1, respectively, in surface horizons. Base saturation (BS) varied from 80 to 92% in surface horizons and from 68 to 91% in the sub-surface horizons. The cation exchange capacity (CEC) varied between 8.6 to 19.9 cmol p+kg-1 in surface horizons and from 2.7 to 17.2 cmol p+kg-1 in the sub-surface horizons. The soils were classified within the Entisols and Inceptisols orders. To ensure sustainable agricultural production within these soils, it is imperative to implement appropriate management strategies to mitigate the impacts of soil degradation.
Optimization of Crystallographic Texture for Sheet-forming Applications Using Taylor-based Models
Authors: Galán-López Jesús , Kestens Leo A. I. 
Published: August 2018

Abstract
Plastic deformation of metallic materials is an inherently anisotropic process as a result of the presence of preferential orientations in their crystallographic texture. Crystal plasticity modeling, which allows simulating the response of polycrystal aggregates taking into account their texture and other microstructural parameters, has been extensively used to predict this behavior. In this work, crystal
plasticity models are used to deal with the opposite problem: given a desired behavior, determine how to modify a texture to approximate this behavior in the most efficient way. This goal can be expressed as an optimization problem, in which the objective is to find the texture with the best formability properties among all the possible ones. An incremental optimization method, based on the gradient descent algorithm, has been developed and applied to different initial textures corresponding to typical steel and aluminum sheet products. According to expectations, the textures found present a stronger

$$\gamma $$

γ

fiber component. Moreover, the method sets the basis for the development of more complicated optimization schemes directed toward optimizing specific materials and forming processes.
Avoid the Goose! Paramedic Identification of Esophageal Intubation by Ultrasound
Authors: Lema Penelope C. , O’Brien Michael , Wilson Juliana , James Erika St. , Lindstrom Heather , DeAngelis John , Caldwell Jennifer , May Paul , Clemency Brian 
Published: August 2018

AbstractObjectivesRapid identification of esophageal intubations is critical to avoid patient morbidity and mortality. Continuous waveform capnography remains the gold standard for endotracheal tube (ETT) confirmation, but it has limitations. Point-of-care ultrasound (POCUS) may be a useful alternative for confirming ETT placement. The objective of this study was to determine the accuracy of paramedic-performed POCUS identification of esophageal intubations with and without ETT manipulation.MethodsA prospective, observational study using a cadaver model was conducted. Local paramedics were recruited as subjects and each completed a survey of their demographics, employment history, intubation experience, and prior POCUS training. Subjects participated in a didactic session in which they learned POCUS identification of ETT location. During each study session, investigators randomly placed an ETT in either the trachea or esophagus of four cadavers, confirmed with direct laryngoscopy. Subjects then attempted to determine position using POCUS both without and with manipulation of the ETT. Manipulation of the tube was performed by twisting the tube. Descriptive statistics and logistic regression were used to assess the results and the effects of previous paramedic experience.ResultsDuring 12 study sessions, from March 2014 through December 2015, 57 subjects participated, evaluating a total of 228 intubations: 113 tracheal and 115 esophageal. Subjects were 84.0% male, mean age of 39 years (range: 22 - 62 years), with median experience of seven years (range: 0.6 - 39 years). Paramedics correctly identified ETT location in 158 (69.3%) cases without and 194 (85.1%) with ETT manipulation. The sensitivity and specificity of identifying esophageal location without ETT manipulation increased from 52.2% (95% confidence interval [CI], 43.0-61.0) and 86.7% (95% CI, 81.0-93.0) to 87.0% (95% CI, 81.0-93.0) and 83.2% (95% CI, 0.76-0.90) after manipulation (P<.0001), without affecting specificity (P=.45). Subjects correctly identified 41 previously incorrectly identified esophageal intubations. Paramedic experience, previous intubations, and POCUS experience did not correlate with ability to identify tube location.Conclusion:Paramedics can accurately identify esophageal intubations with POCUS, and manipulation improves identification. Further studies of paramedic use of dynamic POCUS to identify inadvertent esophageal intubations are needed.LemaPC, O’BrienM, WilsonJ, St. JamesE, LindstromH, DeAngelisJ, CaldwellJ, MayP, ClemencyB.Avoid the goose! Paramedic identification of esophageal intubation by ultrasound. Prehosp Disaster Med.2018;33(4):406–410
‘Real Grounds’ in Matter and Things in Themselves
Authors: Langton Rae 
Published: August 2018

AbstractMatter’s real essence is a ground for certain features of phenomena. Things in themselves are likewise a ground for certain features of phenomena. How do these claims relate? The former is a causal essentialism about physics, Stang argues; and the features so grounded are phenomenally nomically necessary. The latter involves a distinctive ontology of things in themselves, I argue; but the features so grounded are not noumenally nomically necessary. Stang’s version of Kant’s modal metaphysics is admirable, but does not go far enough. Kant’s causal essentialism involves the essences of fundamental properties, as well as of matter. And things in themselves are grounds, because they are substances, the ‘substrate’ of phenomena.
Nicholas Stang’s Kant’s Modal Metaphysics
Authors: McDaniel Kris 
Published: August 2018

AbstractIn this critical review, I focus on two things. First, I respond to Stang’s interpretation of Descartes, according to which Descartes’ endorsement of his ontological argument commits him to possibilism, the doctrine that there are, or at least could be, non-existent individuals. My response consists in presenting a version of Descartes’ argument the acceptance of which does not require the acceptance of possibilism. The second thing I focus on is Stang’s claim that Kant distinguishes several kinds of real possibility. I raise worries about Stang’s formulations of various doctrines of real possibility, and I preliminarily explore how real essence and ground are connected with the various kinds of real necessity Stang’s Kant recognizes.
Experimental implementation of fully controlled dephasing dynamics and synthetic spectral densities
Authors: Liu Zhao-Di , Lyyra Henri , Sun Yong-Nan , Liu Bi-Heng , Li Chuan-Feng , Guo Guang-Can , Maniscalco Sabrina , Piilo Jyrki 
Published: August 2018

AbstractEngineering, controlling, and simulating quantum dynamics is a strenuous task. However, these techniques are crucial to develop quantum technologies, preserve quantum properties, and engineer decoherence. Earlier results have demonstrated reservoir engineering, construction of a quantum simulator for Markovian open systems, and controlled transition from Markovian to non-Markovian regime. Dephasing is an ubiquitous mechanism to degrade the performance of quantum computers. However, all-purpose quantum simulator for generic dephasing is still missing. Here, we demonstrate full experimental control of dephasing allowing us to implement arbitrary decoherence dynamics of a qubit. As examples, we use a photon to simulate the dynamics of a qubit coupled to an Ising chain in a transverse field and also demonstrate a simulation of nonpositive dynamical map. Our platform opens the possibility to simulate dephasing of any physical system and study fundamental questions on open quantum systems.
Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens
Authors: Lin Zihua , Xu Xiaobo , Zhao Sheng , Yang Xiaohong , Guo Jian , Zhang Qun , Jing Chunmei , Chen Shawn , He Yun 
Published: August 2018

AbstractDevelopment of effective antimicrobial agents continues to be a great challenge, particularly due to the increasing resistance of superbugs and frequent hospital breakouts. There is an urgent need for more potent and safer antibiotics with novel scaffolds. As historically many commercial drugs were derived from natural products, discovery of antimicrobial agents from complex natural product structures still holds a great promise. Herein, we report the total synthesis of natural albomycins δ1 (1a), δ2 (1b), and ε (1c), which validates the structures of these peptidylnucleoside compounds and allows for synthetic access to bioactive albomycin analogs. The efficient synthesis of albomycins enables extensive evaluations of these natural products against model bacteria and clinical pathogens. Albomycin δ2 has the potential to be developed into an antibacterial drug to treat Streptococcus pneumoniae and Staphylococcus aureus infections.
Nanophotonic Pockels modulators on a silicon nitride platform
Authors: Alexander Koen , George John P. , Verbist Jochem , Neyts Kristiaan , Kuyken Bart , Van Thourhout Dries , Beeckman Jeroen 
Published: August 2018

AbstractSilicon nitride (SiN) is emerging as a competitive platform for CMOS-compatible integrated photonics. However, active devices such as modulators are scarce and still lack in performance. Ideally, such a modulator should have a high bandwidth, good modulation efficiency, low loss, and cover a wide wavelength range. Here, we demonstrate the first electro-optic modulators based on ferroelectric lead zirconate titanate (PZT) films on SiN, in both the O-band and C-band. Bias-free operation, bandwidths beyond 33 GHz and data rates of 40 Gbps are shown, as well as low propagation losses (α ≈ 1 dB cm−1). A half-wave voltage-length product of 3.2 V cm is measured. Simulations indicate that further improvement is possible. This approach offers a much-anticipated route towards high-performance phase modulators on SiN.
FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
Authors: Shanmughapriya Santhanam , Tomar Dhanendra , Dong Zhiwei , Slovik Katherine J. , Nemani Neeharika , Natarajaseenivasan Kalimuthusamy , Carvalho Edmund , Lu Christy , Corrigan Kaitlyn , Garikipati Venkata Naga Srikanth , Ibetti Jessica , Rajan Sudarsan , Barrero Carlos , Chuprun Kurt , Kishore Raj , Merali Salim , Tian Ying , Yang Wenli , Madesh Muniswamy 
Published: August 2018

AbstractAlthough many factors contribute to cellular differentiation, the role of mitochondria Ca2+ dynamics during development remains unexplored. Because mammalian embryonic epiblasts reside in a hypoxic environment, we intended to understand whether mCa2+ and its transport machineries are regulated during hypoxia. Tissues from multiple organs of developing mouse embryo evidenced a suppression of MICU1 expression with nominal changes on other MCU complex components. As surrogate models, we here utilized human embryonic stem cells (hESCs)/induced pluripotent stem cells (hiPSCs) and primary neonatal myocytes to delineate the mechanisms that control mCa2+ and bioenergetics during development. Analysis of MICU1 expression in hESCs/hiPSCs showed low abundance of MICU1 due to its direct repression by Foxd1. Experimentally, restoration of MICU1 established the periodic cCa2+ oscillations and promoted cellular differentiation and maturation. These findings establish a role of mCa2+ dynamics in regulation of cellular differentiation and reveal a molecular mechanism underlying this contribution through differential regulation of MICU1.
HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction
Authors: Akiyama Hisashi , Miller Caitlin M. , Ettinger Chelsea R. , Belkina Anna C. , Snyder-Cappione Jennifer E. , Gummuluru Suryaram 
Published: August 2018

AbstractLow levels of type I interferon (IFN-I) are thought to be a driving force for immune activation and T-cell exhaustion in HIV-1 infected individuals on combination antiretroviral therapy (cART), though the causative mechanisms for persistent IFN-I signaling have remained unclear. Here, we show Rev–CRM1-dependent nuclear export and peripheral membrane association of intron-containing HIV-1 RNA, independent of primary viral sequence or viral protein expression, is subject to sensing and signaling via MAVS, resulting in IFN-I-dependent pro-inflammatory responses in macrophages. Additionally, HIV-1 intron-containing-RNA-induced innate immune activation of macrophages leads to upregulation of inhibitory receptor expression and functional immune exhaustion of co-cultured T cells. Our findings suggest that persistent expression of HIV-1 intron-containing RNA in macrophages contributes to chronic immune activation and T-cell dysfunction and that use of HIV RNA expression inhibitors as adjunct therapy might abrogate aberrant inflammation and restore immune function in HIV-infected individuals on cART.
High-resolution in situ transcriptomics of Pseudomonas aeruginosa unveils genotype independent patho-phenotypes in cystic fibrosis lungs
Authors: Rossi Elio , Falcone Marilena , Molin Søren , Johansen Helle Krogh 
Published: August 2018

AbstractLife-long bacterial infections in cystic fibrosis (CF) airways constitute an excellent model both for persistent infections and for microbial adaptive evolution in complex dynamic environments. Using high-resolution transcriptomics applied on CF sputum, we profile transcriptional phenotypes of Pseudomonas aeruginosa populations in patho-physiological conditions. Here we show that the soft-core genome of genetically distinct populations, while maintaining transcriptional flexibility, shares a common expression program tied to the lungs environment. We identify genetically independent traits defining P. aeruginosa physiology in vivo, documenting the connection between several previously identified mutations in CF isolates and some of the convergent phenotypes known to develop in later stages of the infection. In addition, our data highlight to what extent this organism can exploit its extensive repertoire of physiological pathways to acclimate to a new niche and suggest how alternative nutrients produced in the lungs may be utilized in unexpected metabolic contexts.
Modeling the impact of drug interactions on therapeutic selectivity
Authors: Weinstein Zohar B. , Kuru Nurdan , Kiriakov Szilvia , Palmer Adam C. , Khalil Ahmad S. , Clemons Paul A. , Zaman Muhammad H. , Roth Frederick P. , Cokol Murat 
Published: August 2018

AbstractCombination therapies that produce synergistic growth inhibition are widely sought after for the pharmacotherapy of many pathological conditions. Therapeutic selectivity, however, depends on the difference between potency on disease-causing cells and potency on non-target cell types that cause toxic side effects. Here, we examine a model system of antimicrobial compound combinations applied to two highly diverged yeast species. We find that even though the drug interactions correlate between the two species, cell-type-specific differences in drug interactions are common and can dramatically alter the selectivity of compounds when applied in combination vs. single-drug activity—enhancing, diminishing, or inverting therapeutic windows. This study identifies drug combinations with enhanced cell-type-selectivity with a range of interaction types, which we experimentally validate using multiplexed drug-interaction assays for heterogeneous cell cultures. This analysis presents a model framework for evaluating drug combinations with increased efficacy and selectivity against pathogens or tumors.
Revealing the mechanisms of membrane protein export by virulence-associated bacterial secretion systems
Authors: Krampen Lea , Malmsheimer Silke , Grin Iwan , Trunk Thomas , Lührmann Anja , de Gier Jan-Willem , Wagner Samuel 
Published: August 2018

AbstractMany bacteria export effector proteins fulfilling their function in membranes of a eukaryotic host. These effector membrane proteins appear to contain signals for two incompatible bacterial secretion pathways in the same protein: a specific export signal, as well as transmembrane segments that one would expect to mediate targeting to the bacterial inner membrane. Here, we show that the transmembrane segments of effector proteins of type III and type IV secretion systems indeed integrate in the membrane as required in the eukaryotic host, but that their hydrophobicity in most instances is just below the threshold required for mediating targeting to the bacterial inner membrane. Furthermore, we show that binding of type III secretion chaperones to both the effector’s chaperone-binding domain and adjacent hydrophobic transmembrane segments also prevents erroneous targeting. These results highlight the evolution of a fine discrimination between targeting pathways that is critical for the virulence of many bacterial pathogens.