bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Purified, Solvent‐Intercalated Precursor Complex for Wide‐Process‐Window Fabrication of Efficient Perovskite Solar Cells and Modules
Authors: Ozaki Masashi , Shimazaki Ai , Jung Mina , Nakaike Yumi , Maruyama Naoki , Yakumaru Shinya , Rafieh Alwani Imanah , Sasamori Takahiro , Tokitoh Norihiro , Ekanayake Piyasiri , Murata Yasujiro , Murdey Richard , Wakamiya Atsushi 
Published: April 2019

AbstractA high‐purity methylammonium lead iodide complex with intercalated dimethylformamide (DMF) molecules, CH3NH3PbI3⋅DMF, is introduced as an effective precursor material for fabricating high‐quality solution‐processed perovskite layers. Spin‐coated films of the solvent‐intercalated complex dissolved in pure dimethyl sulfoxide (DMSO) yielded thick, dense perovskite layers after thermal annealing. The low volatility of the pure DMSO solvent extended the allowable time for low‐speed spin programs and considerably relaxed the precision needed for the antisolvent addition step. An optimized, reliable fabrication method was devised to take advantage of this extended process window and resulted in highly consistent performance of perovskite solar cell devices, with up to 19.8 % power‐conversion efficiency (PCE). The optimized method was also used to fabricate a 22.0 cm2, eight‐cell module with 14.2 % PCE (active area) and 8.64 V output (1.08 V/cell).
Study on CO2 facilitated separation of mixed matrix membranes containing surface modified MWCNTs
Authors: Zhang Beibei , Fu Jiawen , Zhang Qingfu , Yi Chunhai , Yang Bolun 
Published: April 2019

ABSTRACTMixed matrix membranes (MMMs) for CO2‐facilitated separation were prepared by incorporating different surface‐modified multiwalled carbon nanotubes (MWCNTs) in a fixed carrier membrane material. Polymer containing amino groups, poly(vinylalcohol‐co‐vinylamine) (VA‐co‐VAm) was synthesized as polymeric matrix. MWCNTs as well as MWCNTs surface‐modified with OH and NH2 were applied as nanofillers. The physical property, chemical structure, and membrane morphology were characterized by FT‐IR, TG, XRD, DSC, CA, XPS, and SEM. The effects of content, functional group, temperature, and pressure on gas permselectivity were studied. Results show that the incorporation of nanofillers can effectively restrict the polymer chain packing and lead to low crystallinity. The MMMs exhibited higher CO2 permselectivity than the pure polymeric membrane. For all the MMMs, the CO2 permeance and selectivity increased with MWCNTs contents to a maximum and then decreased. MWCNT‐NH2 can be regarded as the most effective nanofiller. MMMs with 2.0 wt % MWCNT‐NH2 displayed the highest CO2 permeance of 132 GPU and CO2/N2 selectivity of 74. Both CO2 permeance and selectivity were decreased with feed gas pressure and temperature. The membrane exhibited good stability in the testing with the binary gas mixtures of CO2/N2 for 110 h under 0.54 MPa. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47848.
DDC plays vital roles in the wing spot formation, egg production, and chorion tanning in the brown planthopper
Authors: Lu Jia‐Bao , Zhang Meng‐Qiu , Li Ling‐Chen , Zhang Chuan‐Xi 
Published: April 2019

AbstractThe gene dopa decarboxylase (Nlddc) of the brown planthopper (BPH, Nilaparvata lugens) was identified in the genome and transcriptome of the insect. The open reading frame of Nlddc is 1,434 bp in length and, it has the potential to encode a protein of 477 amino acid with a conserved pyridoxal‐dependent decarboxylase domain and a typical motif, NFNPHKW. Real‐time quantification polymerase chain reaction analyses revealed that this gene was highly expressed in the integument and brain, and transcript level peaked in the late stages of egg period and each nymph instar with periodicity. RNA interference results revealed that Nlddc played essential roles in pigment synthesis, formation of wing spot, egg production, and tanning of the chorion. A rapid accumulation of Nlddc transcripts was detected, and it coincided with the injection of the hormone 20‐hydroxyecdysone (20E), suggesting that Nlddc transcription was regulated by 20E.
Fußgängerbrücke Dejima, Nagasaki, JP
Authors: Ney Laurent , Burgmann Karl 
Published: April 2019

AbstractDie neue Dejima‐Fußgängerbrücke hat eine Länge von 38,50 m und eine Breite von 4,40 m. Es handelt sich um eine Stahlkonstruktion. Der Gehwegbelag besteht aus Holz. Der zurückhaltende Entwurf und der verwendete Maßstab wurden durch den historischen Kontext beeinflusst.
Human carotid atherosclerotic plaque protein(s) change HDL protein(s) composition and impair HDL anti‐oxidant activity
Authors: Cohen Elad , Aviram Michael , Khatib Soliman , Volkova Nina , Vaya Jacob 
Published: April 2019

AbstractHigh density lipoprotein (HDL) anti‐atherogenic functions are closely associated with cardiovascular disease risk factor, and are dictated by its composition, which is often affected by environmental factors. The present study investigates the effects of the human carotid plaque constituents on HDL composition and biological functions. To this end, human carotid plaques were homogenized and incubated with HDL. Results showed that after incubation, most of the apolipoprotein A1 (Apo A1) protein was released from the HDL, and HDL diameter increased by an average of approximately 2 nm. In parallel, HDL antioxidant activity was impaired. In response to homogenate treatment HDL could not prevent the accelerated oxidation of LDL caused by the homogenate. Boiling of the homogenate prior to its incubation with HDL abolished its effects on HDL composition changes. Moreover, tryptophan fluorescence quenching assay revealed an interaction between plaque component(s) and HDL, an interaction that was reduced by 50% upon using pre‐boiled homogenate. These results led to hypothesize that plaque protein(s) interacted with HDL‐associated Apo A1 and altered the HDL composition. Immuno‐precipitation of Apo A1 that was released from the HDL after its incubation with the homogenate revealed a co‐precipitation of three isomers of actin. However, beta‐actin alone did not significantly affect the HDL composition, and yet the active protein within the plaque was elusive. In conclusion then, protein(s) in the homogenate interact with HDL protein(s), leading to release of Apo A1 from the HDL particle, a process that was associated with an increase in HDL diameter and with impaired HDL anti‐oxidant activity. © 2015 BioFactors, 42(1):115–128, 2016
Chiral separation and thermodynamic investigation of WCK 3023: A novel oxazolidinone antibacterial agent, application to pre‐clinical pharmacokinetic study
Authors: Ahirrao Vinod , Rane Vipul , Patil Kiran , Jadhav Rajiv , Patel Anasuya , Patil Vijay , Yeole Ravindra 
Published: April 2019

AbstractA chiral liquid chromatographic method was developed and validated for the quantification of R‐enantiomer impurity (RE) in WCK 3023 (S‐enantiomer), a new drug substance. The separation was achieved on Chiralpak IA (amylose‐based immobilized chiral stationary phase), using a mobile phase consisting of n‐hexane–ethanol–trifluoroacetic acid (70:30:0.2, v/v/v) at a flow rate of 1.0 mL/min. The method was extensively validated for the quantification of RE in WCK 3023 and proved to be robust. For RE the detector response was linear over the concentration range of 0.11–5 μg/mL. The limit of quantitation and limit of detection for RE were 0.11 and 0.04 μg/mL respectively. Average recovery of the RE was in the range of 98.11–99.55%. The developed method was specific, sensitive, precise and accurate for quantitative determination of RE in WCK 3023. The impact of thermodynamic parameters on the chiral separation was evaluated. The method was employed for controlling the enantiomeric impurity in the lots of WCK 3023 used for pre‐clinical studies. The method was successfully applied to evaluate the possible conversion of WCK 3023 to RE in rat serum samples during pre‐clinical pharmacokinetic studies.
Percutaneous device embolization of an aneurysmal pulmonary artery in an infant weighing <3 kilograms
Authors: Reynolds Kathryn , Stapleton Gary , Herbert Carrie , Mauriello Daniel 
Published: April 2019

AbstractPulmonary artery aneurysm (PAA) and pulmonary artery pseudoaneurysm (PAP) are rare diagnoses in the pediatric population and carry a high risk of mortality if rupture occurs. There is currently no standard therapeutic approach to PAAs and PAPs. Reports of surgical intervention describe high mortality. We present a case of an infant with a PAP that was successfully treated with a percutaneous device closure. Our approach included deployment of a 6‐mm Amplatzer Vascular Plug 2 (Abbott, St. Paul, MN) in the right lower pulmonary artery segmental branch just proximal to the origin of the pseudoaneurysm. Subsequent imaging 1‐month post‐procedure demonstrated a >50% reduction in the size of the PAP when compared to original imaging studies and near‐complete resolution 14 months following the intervention. Percutaneous device placement to occlude the vessel supplying peripheral PAAs and PAPs may be a reasonable alternative to open surgical resection when treating patients with this rare, but potentially life‐threatening vascular anomaly. To our knowledge, this is the first case describing a successful device closure of a PAP in an infant weighing <3 kg.
Monitoring Conformational Changes in an Enzyme Conversion Inhibitor Using Pure Shift Exchange NMR Spectroscopy
Authors: Aloui G. , Bouabdallah S. , Baltaze J. P. , Pucheta J. E. H. , Touil S. , Farjon J. , Giraud N. 
Published: April 2019

AbstractWe report the acquisition of 2D NMR EXSY spectra with ultrahigh resolution, which allows for probing the slow conformational exchange process in a pharmaceutical compound. The resolution enhancement is achieved by implementing interferogram based PSYCHE homonuclear decoupling to generate a pure shift proton spectrum along the direct domain of the resulting data. The performance of this pure shift EXSY pulse sequence is compared to the standard experiment recorded under identical conditions. It is found that although being less sensitive and requiring a longer acquisition time, the quality of pure shift spectra allows for extracting exchange rates values that are coherent with the ones determined by standard approach, on a temperature range that demonstrates the robustness of the chosen homonuclear decoupling method. The resolution enhancement provided by the simplification of proton line shape allows for probing a higher number of proton sites whose analysis would have been biased using a standard method. These results open the way to a thorough and accurate study of chemical exchange processes based on a multi‐site analysis of 2D pure shift EXSY spectra
Berberine inhibits the interleukin‐1 beta‐induced inflammatory response via MAPK downregulation in rat articular chondrocytes
Authors: Li Xing , He Peiheng , Hou Yu , Chen Shudong , Xiao Zhifeng , Zhan Jiheng , Luo Dan , Gu Minghui , Lin Dingkun 
Published: April 2019

AbstractOsteoarthritis (OA) is one of the most chronic degenerative arthritic diseases, which gradually results in chondrocyte changes, articular cartilage degeneration, subchondral bone sclerosis, joint pain, swelling, and dysfunction. Berberine (BBR) has various confirmed biological activities, such as anti‐inflammatory and antioxidant activities. However, the effect of BBR on the production of inflammation‐associated proteins, including inducible nitric oxide synthase (iNOS), cyclooxygenase (Cox)‐2, metalloproteinases (MMPs), Collagen II, TNF‐α, and IL‐6 via the MAPK (mitogen‐activated protein kinases) pathway in IL‐1β‐stimulated rat chondrocytes, has not yet been studied. Thus, the purpose of this study was to evaluate whether BBR would decrease the production of inflammation‐associated proteins through the MAPK signal pathway. Rat chondrocytes were cultured and pretreated with BBR at different concentrations (0, 25, 50, and 100 μM) and then stimulated with or without IL‐1β (10 ng/mL). The mRNA expression of iNOS, COX‐2, MMP‐3, MMP‐13, TNF‐α, and IL‐6 was measured by real‐time polymerase chain reaction (RT‐PCR), and the protein expression of iNOS, COX‐2, Collagen II, MMP‐3,MMP‐13, and MAPKs were measured by Western blotting. The results showed that the expression of iNOS, COX‐2, MMP‐3, MMP‐13, TNF‐α, and IL‐6 increased in the IL‐1β‐treated group and BBR showed an ability to inhibit the elevated expression under the pretreatment. Furthermore, the IL‐1β‐induced downregulation of Collagen II could be ameliorated by BBR. Moreover, the expression of MAPKs was significantly decreased by BBR. These results demonstrated that BBR had the anti‐catabolic and anti‐inflammation abilities that were through the MAPKs in IL‐1β‐induced rat chondrocytes. These findings may provide a novel therapeutic choice for treatment of OA using BBR.
Unhealthy eating and weight dissatisfaction in adolescents who never, occasionally, or regularly use smokeless tobacco (Swedish snus)
Authors: Reas Deborah L. , Wisting Line , Stedal Kristin , Dahlgren Camilla Lindvall 
Published: April 2019

AbstractObjectiveAlthough cigarette smoking has been linked to weight‐related concerns and unhealthy weight control practices, little is known about weight dissatisfaction and eating among adolescents who use smokeless tobacco (SLT) products. The use of Swedish moist snuff (snus) has increased dramatically over recent years, surpassing cigarette smoking among young people in several countries. This study investigated differences in unhealthy eating behaviors and weight dissatisfaction in male and female adolescents who never, occasionally, or regularly use snus.MethodAdolescents aged 16–19 years enrolled in high school (11th, 12th, and 13th grades) completed a cross‐sectional, online survey of adolescent health and well‐being. Meal skipping and snus use frequency were assessed in the total sample (N = 23,622), and items assessing weight dissatisfaction (n = 4,195) and eating‐related pathology (n = 3,563) were administered to subsamples. Analyses were adjusted for cigarette smoking, parental education, and socioeconomic status.ResultsAdolescents who used snus, especially on a daily basis, reported less regular breakfast, lunch, and dinner consumption. Females who used snus on an occasional basis reported significantly more disturbed eating pathology. Snus use was associated with weight dissatisfaction in males and females, manifesting differentially according to gender and snus use frequency.DiscussionUnhealthy eating behaviors and weight dissatisfaction were significantly elevated among snus users aged 16–19 years. An increased awareness that occasional snus use may signal disturbed eating pathology among adolescent females is important for detection and prevention efforts. Parents, schools, and health professionals should be vigilant for possible snus use among weight‐dissatisfied adolescents.
Development and evaluation of lutein‐loaded alginate microspheres with improved stability and antioxidant
Authors: Huang Jin , Bai Feifei , Wu Yanchen , Ye Qingzhuo , Liang Dong , Shi Caihong , Zhang Xiangrong 
Published: April 2019

AbstractBackgroundLutein has been of great interest to the food processing and pharmaconutrient industries owing to its beneficial effects on human health. However, lutein is very sensitive to heat, light, pH and oxidative conditions, which limits its application in food systems. The present study aimed to prepare lutein–alginate microspheres by a calcium chloride gelation method with the purpose of improving the stability and antioxidant abilities of lutein.ResultsThe loading capacity of lutein in the microspheres was approximately 5.3% (w/w) and the entrapment efficiency was about 63%. The loaded microspheres were nearly spherical with an average size of 150 μm. They exhibited a crimped surface by scanning electron microscopy. The lutein was in amorphous state by X‐ray powder diffraction. Analysis by Fourier transform infrared spectroscopy and molecular docking revealed an intermolecular hydrogen bond interaction between lutein and sodium alginate. In vitro release experiments showed that the microspheres presented slower release at acidic conditions than at neutral intestinal conditions. The 2,2‐diphenyl‐1‐picrylhydrazyl radical scavenging activity of the microencapsulated lutein was higher than that of free lutein. The stability of lutein in the microspheres was improved significantly when compared with that of free lutein at various temperatures.ConclusionThe present work successfully developed well‐protected lutein–alginate microspheres. This indicates that it is feasible to use microspheres loaded with lutein as antioxidant functional ingredients in food products. © 2019 Society of Chemical Industry
Impact of climate change on aflatoxin M1 contamination of raw milk with special focus on climate conditions in Serbia
Authors: Milićević Dragan , Petronijević Radivoj , Petrović Zoran , Đjinović‐Stojanović Jasna , Jovanović Jelena , Baltić Tatjana , Janković Saša 
Published: April 2019

AbstractBackgroundThe impact of climate change has been identified as an emerging issue worldwide owing to potential effects that can provoke changes in the nature and occurrence of food safety hazards. Mycotoxins are a group of naturally occurring toxic substances produced by several genera of filamentous fungi, among which, primarily aflatoxins, fumonisins, ochratoxins, trichothecenes and zearalenone are of the greatest concern owing to their negative impact on human health, animal productivity and international trade.ResultsExtreme weather conditions such as floods and droughts which have not occurred previously in Serbia may be supporting factors for contamination of crops by various species of toxigenic fungi and their related mycotoxins. In this study, principal component analysis (PCA) and multivariate analyses were used as powerful tools allowing better understanding of the range of climate factors impacting on crop contamination by mycotoxins. Among the selected environmental variables, temperature and moisture significantly influenced aflatoxin production. Recent drought and then flooding confirmed that Serbia is one of the few European countries with very high risk exposure to natural hazards, as well as that mycotoxins are one of the foodborne hazards most susceptible to climate change. Thus climate change effects on mycotoxigenic fungi and mycotoxin contamination are now receiving scientific attention, especially from a risk analysis perspective.ConclusionThis paper evaluates the available information on the influence of climate change on mycotoxin contamination, especially aflatoxin M1 (AFM1). In addition, this investigation should beneficially contribute to more accurate predictions of the regional risk from mycotoxins in future decades. © 2019 Society of Chemical Industry
Responses of bladder smooth muscle to the stretch go through extracellular signal‐regulated kinase (ERK)/p90 ribosomal S6 protein kinase (p90RSK)/Nuclear factor‐κB (NF‐κB) Pathway
Authors: Li Yaohui , He Minke , Lin Wenyao , Xiang Zhuoyi , Huang Jiaqi , Xu Peirong , Shi Yi , Wang Hang 
Published: April 2019

AbstractAimsThe present study was designed to study changes and its potential mechanisms in human bladder smooth muscle subjected to stretch.MethodsBioinformatics analyses including differential expression analysis, overrepresentation enrichment analysis, principal component analysis, and weighted gene coexpression network analysis were used to analyze a microarray dataset (GSE47080) of partial bladder outlet obstruction (pBOO) in rat to find the potential changes of gene expressions. Bladder from pBOO model and human bladder smooth muscle cells (HBSMCs) subjected to sustained prolonged stretch were collected for Western blot analysis, real‐time polymerase chain reaction, and fluorescence analysis to verify the changes of gene expressions and preliminarily study the potential role of signaling pathway regulation in treatment of pBOO.ResultsThe bioinformatics analysis showed that chronic obstruction activated mitogen‐activated protein kinase pathway and changed cytoskeleton structure in bladder smooth muscle. In in vivo experiments in mice, pBOO was verified by cystometry. Partial BOO activated the extracellular signal‐regulated kinase (ERK)/p90 ribosomal S6 protein kinase (p90RSK)/nuclear factor‐κB (NF‐κB) signaling pathway in DM. The messenger RNA (mRNA) expressions of contractile phenotypic proteins increased after pBOO. In in vitro experiments of HBSMCs, mechanical stretch activated ERK/p90RSK/NF‐κB in HBSMCs in a time‐dependent manner. The mRNA expressions of α‐smooth muscle actin and SM22 also increased and filamentous actin (F‐actin) polymerization was enhanced as well. Inhibition of ERK/p90RSK/NF‐κB pathway reversed mechanical stretch‐induced changes of contractile phenotypic expression and F‐action polymerization.ConclusionsContinuous stretch increases expressions of contractile phenotypic proteins and promotes the polymerization of F‐actin. This process partially goes through ERK/p90RSK/NF‐κB pathway.
An alternative avenue for high‐performance phenolic resin/graphene composite
Authors: Zhao Shuai , Cui Jian , Zhang Guangfa , Gao Ailin , Yan Yehai 
Published: April 2019

AbstractPhenolic resin (PR) grafted graphene (G‐PR), synthesized from the versatile graphene modification platform 2‐(3, 4‐dihydroxyphenyl) pyrrolidine grafted pristine graphene (G‐OH), is used to develop high‐performance phenolic composites. Benefiting from good properties of G‐PR, uniform dispersion of G‐PR and strong PR/G‐PR interfacial interaction, G‐PR shows obvious advantages as a filler in improving mechanical, electrical, and thermal properties of PR over pristine graphene (pG) and graphene oxide (GO) derivatives. For PR/G‐PR composites, the maximum tensile strength attains 51.4 MPa at 0.5 wt% graphene content. Electrical and thermal conductivities reach to 10−3 S·cm−1 and 0.374 W·m−1·k−1 at 5 wt% graphene content, respectively. The decomposition temperature and residue at 800°C separately increase by 61°C and 3.5 wt% at 1 wt% graphene content. In a word, this contribution provides an alternative avenue for preparing high‐performance and multifunctional PR/graphene composites, avoiding the high risk and serious pollution of graphene oxide (GO) avenue.
Study of temperature classification, spark ignition and drop test assessment on secondary cells for intrinsically safe equipment for explosive atmospheres
Authors: Ahirwal Bhagirath , Vishwakarma Rajendra K. 
Published: April 2019

AbstractIn any explosive atmosphere the cell/battery (pack of secondary cells) is used in handheld intrinsically safe (IS) apparatus. The cell is a rechargeable battery. Chemically similar cells of different makes were assessed for maximum surface temperature followed by the spark ignition test as per IS/IEC 60079‐11. It was observed that the maximum surface temperature, open voltage, and short circuit current varied among cells having the same maker and nominal capacity. The cells were not vented or leaked or exploded during the short circuit test for determining the temperature class of cells. The cells with protection circuit had passed in spark ignition test but failed without protection circuit. It may be recommended that the cell should not be used without appropriate protection circuit even in a low power rating certified IS circuit for hazardous areas. A study was also carried out for spark ignition test on different cells connected to the IS protection circuit and the certified IS apparatus as a composite circuit. Each cell was encapsulated along with IS protection circuit and endured drop test successfully. This study was revealed that cell(s) may be used with appropriate IS protection circuit for IS apparatus/equipment.