bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long Noncoding RNAs of the Arterial Wall as Therapeutic Agents and Targets in Atherosclerosis
Authors: Holdt Lesca M. , Kohlmaier Alexander , Teupser Daniel 
Published: July 2019

AbstractLong noncoding ribonucleic acids (lncRNAs) have been defined as transcripts which are > 200 ribonucleotides in size and are not translated into protein. Recent work has shown that many lncRNAs do have specific molecular functions and biological effects, and are involved in a growing number of diseases, including atherosclerosis. As a consequence, lncRNAs are also becoming interesting targets for therapeutic intervention. Here, we focus on lncRNAs which are expressed in the arterial wall, and describe potential RNA therapeutic approaches of atherosclerosis by manipulating lncRNAs without affecting genome deoxyribonucleic acid content: Starting out with an overview of all lncRNAs that have so far been implicated in atherosclerosis by in vivo studies, we describe methodologies for their activation, inactivation, and RNA sequence manipulation. We continue by addressing how artificial (nonnative) therapeutic lncRNAs may be designed, and which molecular functions these designer lncRNAs may exploit. We conclude with an outlook on approaches for chemical lncRNA modification, RNA mass production, and site-specific therapeutic delivery.
Correlation of Site and Size of Tympanic Membrane Perforation and Middle Ear Air Space Volume with Magnitude of Hearing Loss
Authors: Virk Ramandeep Singh , Kudawla Krishan , Bansal Sandeep , Rathod Ramya , Behera Samarendra 
Published: July 2019

Abstract
Introduction The effects of tympanic membrane perforations on middle ear sound transmission are not well characterized, largely because ears with perforations typically have additional pathological changes. It has been established that the larger the perforation, the greater is the hearing loss (HL).
Aim This study aimed to correlate the location and size of tympanic membrane perforation and middle ear air space volume with the magnitude of HL in patients with tubotympanic or inactive mucosal type of chronic otitis media (COM).
Materials and Methods A prospective clinical study of patients with tympanic membrane perforations due to COM and without any other ear disease and who attended the Otolaryngology services at our institute between July 2010 and December 2011 was conducted. A total of 300 ears were evaluated by performing otoendoscopy, followed by photo documentation and audiological investigations (pure-tone audiometry and tympanometry). Tympanic membrane perforations were categorized based on their size and location, and the mean air-bone (AB) gap between the various types of perforations was compared and statistically analyzed with significance level of p < 0.05.
Results Out of 300 ears, maximum number of ears (n = 124, 41.3%) had large-sized perforations (> 30 mm2) that had a maximum mean AB gap of 26.43 dB, and minimum number of ears (n = 60, 20%) had small-sized perforations (0–9 mm2) that had minimum mean AB gap of 9.12 dB. The remaining were medium-sized perforations that had mean AB gap of 16.13 dB. Depending on the location, maximum were central perforations (n = 198, 66%) and minimum were anterosuperior (AS) perforations (n = 9, 3%). Based on the middle ear volume on tympanometry, maximum ears were of low-volume group (n = 246, 92%) that had larger mean AB gap of 19.96 dB HL when compared with the high-volume group (n = 24, 8%) with 11.80 dB HL. AB gap was maximum at lower frequencies and decreased with increase in frequencies except at 4,000 Hz, that is, 56.9 dB HL at 250 Hz, 42.6 at 500 Hz, 41.5 at 1,000 Hz, 32.4 at 2,000 Hz, and 49.5 at 4,000 Hz.
Conclusion HL increases as the area of tympanic membrane perforation increases. There is an inverse relationship between HL and middle ear air space volume. Comparing the small-sized perforations at different sites with the middle ear volume being low, it was found that posterosuperior (PS) perforations had 4 to 7 dB greater HL than AS and anteroinferior (AI). However, the relationship was statistically insignificant. The phase cancellation effect of round window causing greater HL in posteroinferior (PI) perforations does not exist in small- and medium-sized perforations. HL is greater at lower frequencies and less at higher frequencies.
Differential Diagnosis of Vertigo in Children
Authors: Bhandari Anita , Goswami Arpana 
Published: July 2019

Abstract
Introduction Vertigo and balance disorders can affect all age groups. It is common to misdiagnose the cause of dizziness in children, which eventually results in the delay of treatment. The purpose of this study was to review the clinical characteristics and neurotological evaluation of vertigo in patients younger than 16 years and assist in making a differential diagnosis for children with vertigo and balance disorders. The differential diagnosis can help determine the correct management strategy to treat vertigo and imbalance in pediatric patients.
Methods Children and adolescents presenting with a chief complaint of vertigo or unsteadiness to Vertigo and Ear Clinic, Jaipur, were selected for this study on the basis of clinical history, physical examination, and neurotological evaluation.
Results A total of 90 patients with a mean age of 10.67 years were evaluated. The most common cause associated with vertigo or dizziness was found to be vestibular migraine seen in 38 participants of this study. This was followed by unilateral peripheral vestibulopathy in 15 patients, bilateral peripheral vestibulopathy in 11 patients, and central vestibulopathy in 6 patients. Vertigo was also seen to be associated with various other disorders.
Conclusion Vertigo in children must be recognized as a definite symptom, which should be taken seriously by the clinician and family. Pediatric vertigo can be due to many etiologies. History and evaluation are the only way to diagnose the etiology and site of lesion. This will prevent misdiagnosis and delay in the treatment, which can ultimately lead to deterioration of the quality of life.
Ultraefficient thermophotovoltaic power conversion by band-edge spectral filtering
Authors: Omair Zunaid , Scranton Gregg , Pazos-Outón Luis M. , Xiao T. Patrick , Steiner Myles A. , Ganapati Vidya , Peterson Per F. , Holzrichter John , Atwater Harry , Yablonovitch Eli 
Published: July 2019

Significance
Thermophotovoltaic conversion utilizes thermal radiation to generate electricity in a photovoltaic cell. On a solar cell, the addition of a highly reflective rear mirror maximizes the extraction of luminescence, which in turn boosts the voltage. This has enabled the creation of record-breaking solar cells. The rear mirror also reflects low-energy photons back into the emitter, recovering the energy. This radically improves thermophotovoltaic efficiency. Therefore, the luminescence extraction rear mirror serves a dual function; boosting the voltage, and reusing the low-energy thermal photons. Owing to the dual functionality of the rear mirror, we achieve a thermophotovoltaic efficiency of 29.1% at 1,207 °C, a temperature compatible with furnaces, and a new world record at temperatures below 2,000 °C.
Site-specific phosphorylation of myosin binding protein-C coordinates thin and thick filament activation in cardiac muscle
Authors: Ponnam Saraswathi , Sevrieva Ivanka , Sun Yin-Biao , Irving Malcolm , Kampourakis Thomas 
Published: July 2019

Significance
Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) is a key regulator of myocardial contractility, and dephosphorylation of cMyBP-C is associated with heart failure. However, the molecular mechanisms underlying contractile regulation by cMyBP-C phosphorylation are poorly understood. We describe the kinase specificity of the multiple phosphorylation sites on cMyBP-C and show that they are interdependent and have distinct effects on the structure of the thin and thick filaments. The results lead to a model of regulation by cMyBP-C phosphorylation through altered affinity of cMyBP-C’s N terminus for thin and thick filaments, as well as their structures and associated regulatory states. Impairment of these mechanisms is likely to underlie the functional effects of mutations in filament proteins associated with cardiomyopathy.
Encapsulation of hydrophobic components in dendrimersomes and decoration of their surface with proteins and nucleic acids
Authors: Torre Paola , Xiao Qi , Buzzacchera Irene , Sherman Samuel E. , Rahimi Khosrow , Kostina Nina Yu. , Rodriguez-Emmenegger Cesar , Möller Martin , Wilson Christopher J. , Klein Michael L. , Good Matthew C. , Percec Virgil 
Published: July 2019

Significance
Lipid vesicles are globular assemblies that compartmentalize, encapsulate, transport, and provide signal transmission and communication between cells. In living systems, these vesicles perform critical functions to sustain life. Biomimetic lipid vesicles, such as liposomes, have been developed as mimics of biological cell membranes and for applications in biotechnology, but they do have specific limitations. Dendrimersomes are vesicles self-assembled from amphiphilic Janus dendrimers. They offer improved stability and versatility over liposomes. These dendrimersomes are extremely efficient at loading hydrophobic small molecules and natural macromolecules including folded proteins, at a level higher than comparable liposomes. Additionally, they can be readily functionalized to enable modular recruitment of proteins and nucleic acids on their periphery.
PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization
Authors: Lopez Mitchell L. , Lo Megan , Kung Jennifer E. , Dudkiewicz Małgorzata , Jang Gwendolyn M. , Von Dollen John , Johnson Jeffrey R. , Krogan Nevan J. , Pawłowski Krzysztof , Jura Natalia 
Published: July 2019

Significance
Protein kinases are exceptionally important and effective targets in human diseases, but a significant proportion of the human kinome remains uncharacterized and consequently unexplored as potential therapeutic targets. Here, we describe a kinase not annotated in the original human kinome, C19orf35/PEAK3, which shares structural similarities with PEAK1/Sgk269 and Pragmin/SgK223 pseudokinases. Our work reveals the cellular pool of PEAK3 binding partners and focuses on cellular phenotypes resulting from the PEAK3-dependent inhibition of CrkII, an adaptor protein that controls cell migration. Most importantly, we investigate how the structure and dimerization of the PEAK3 pseudokinase domain regulates its behavior, which highlights potential avenues for pharmacological regulation of PEAK3 function.
Effects of Quantum Fluctuations on

PT

-Symmetric Solitons of a Trapped Bose Gas*
Authors: Qi Wei , Dong Liang-Wei , Li Hai-Feng 
Published: July 2019

Abstract

Considering the quantum fluctuation effects, the existence and stability of solitons in a Bose-Einstein condensate subjected in a

P
T

-symmetric potential are discussed. Using the variational approach, we investigate how the quantum fluctuation affects the self-localization and stability of the condensate with attractive two-body interactions. The results show that the quantum fluctuation dramatically influences the shape, width, and chemical potential of the condensate. Analytical variational computation also predicts there exists a positive critical quantum fluctuation strength qc with each fixed attractive two-body interaction g
0, if the quantum fluctuation strength q
0
is bigger than qc, there is no bright soliton solution existence. We also study the effects of the quantum fluctuations on the stability of solitons using the Vakhitov-Kolokolov (VK) stability criterion. A robust stable bright soliton will always exist when the quantum fluctuation strength q
0
belongs to the parameter regimes qc
≥ q
0 > 0.
Investigation of Binding Energy and Potential in Mesons
Authors: Khalaghi Alireza , Monemzadeh Majid , Tazimi Narges 
Published: July 2019

Abstract

Truly by looking through the analytical model of constituent quarks and further the importance of the effects of relativity on quark dynamics in studying the interior structure of mesons, in this research we have strived to have a much more precise modeling for quark interior structure. Certainly by observing the constituent model of quarks, at first we consider the mesons as two-body system, then we place the considered calculated Potential, which is a function of location and spin, in Schrödinger’s equation. Next we will solve the mentioned equation in analytical method. Moving on this solution, we will import the spin and isospin interactions as perturbation in our problem, and finally by using these solutions we can obtain both binding energy and wave function for bound state and excited states of meson. Eventually, by applying these calculations in the next and last step we will compare our data about meson’s binding energy and masses with others results.
Two New Hyperon Coupling Models in the Light of the Massive Neutron Star PSR J0348+0432*
Authors: Hong Bin , Ren Zhong-Zhou , Bai Dong 
Published: July 2019

Abstract

In the context of the relativistic mean field theory, we propose two new hyperon coupling models, namely the limitation model and the potential well depth model, in the light of the observed data for the massive neutron PSR J0348+0432. The radius of PSR J0348+0432 given by the limitation model is found to be 12.52 km ∼ 12.97 km, while the radius given by the potential well depth model is found to be 12.19 km ∼ 12.89 km. We also calculate the gravitational redshift of PSR J0348+0432 within these two models, for which the limitation model gives 0.346 ∼ 0.391 and the potential well depth model gives 0.350 ∼ 0.409. Further exploration of these two models shows that, these two models are almost degenerate for neutron stars lighter than 1.85 M
⊙, and start to give different results for massive neutron stars heavier than 1.85 M
⊙. Therefore, the studies of massive neutron stars could be crucial for discriminating these two models and help deepen our understanding of hyper-nuclear interactions.
Constraints on H0 from WMAP and BAO Measurements*
Authors: Zhang Xue , Huang Qing-Guo 
Published: July 2019

Abstract

We report the constraints of H
0
obtained from Wilkinson Microwave Anisotropy Probe (WMAP) 9-year data combined with the latest baryonic acoustic oscillations (BAO) measurements. We use the BAO measurements from 6dF Galaxy Survey (6dFGS), the SDSS DR7 main galaxies sample (MGS), the BOSS DR12 galaxies, and the eBOSS DR14 quasars. Adding the recent BAO measurements to the cosmic microwave background (CMB) data from WMAP, we constrain cosmological parameters Ω
m
= 0.298 ± 0.005,

H
0

=

68.36

−
0.52

+
0.53

km
⋅

s

−
1

⋅

Mpc

−
1

,

σ
8

=

0.8170

−
0.0175

+
0.0159

in a spatially flat Λ cold dark matter (ΛCDM) model, and Ω
m
= 0.302 ± 0.008, H
0 = 67.63 ± 1.30 km ⋅ s−1 ⋅ Mpc−1,

σ
8

=

0.7988

−
0.0338

+
0.0345

in a spatially flat wCDM model, respectively. Our measured H
0
results prefer a value lower than 70 km ⋅ s−1 ⋅ Mpc−1, consistent with the recent data on CMB constraints from Planck (2018), but in 3.1 and 3.5σ tension with local measurements of SH0ES (2018) in ΛCDM and wCDM framework, respectively. Our results indicate that there is a systematic tension on the Hubble constant between SH0ES and the combination of CMB and BAO datasets.
Scalar Tensor Cosmology With Kinetic, Gauss-Bonnet and Nonminimal Derivative Couplings and Supersymmetric Loop Corrected Potential
Authors: El-Nabulsi Rami Ahmad 
Published: July 2019

Abstract

We discuss a particular four-dimensional cosmology based on non-minimal scalar tensor theories characterized by a supersymmetric loop corrected potential and a Hubble parameter defined as a function of the scalar field. Power-law solutions are obtained in the FRW background giving rise to acceleratedly expanding universe characterized by a scale factor and a scalar field depending both on the non-minimal coupling parameter ξ. Based on SNeIa data and on Hubble data X-ray gas mass fraction measurements, we find 0.116 < ξ < 0.225 which results on a universe dominated by vacuum energy.
Doubly Excited 1,3Fe States of Two-Electron Atoms under Weakly Coupled Plasma Environment*
Authors: Dutta S. , Saha J. K. , Bhattacharyya S. , Mukherjee T. K. 
Published: July 2019

Abstract

Precise energy eigenvalues of metastable bound doubly excited
1,3
Fe states originating from 2pnf (n = 4–6) configuration of helium-like ions (Z = 2–4) under weakly coupled plasma (WCP) environment have been estimated within the framework of Ritz variational method. The wavefunction is expanded in explicitly correlated Hylleraas type basis set. The screened Coulomb potential is considered mimic the WCP environment. The atomic systems tend towards gradual instability and the number of excited metastable bound states reduces with increasing plasma strength. The wavelengths corresponding to 2pnf (1,3
F
e) → 2pn′d (1,3
D
o) (n = 4–6; n′ = 3–6) transitions occurring between doubly excited states of plasma embedded two-electron ions are also reported.
Hydrodynamic Stress Tensor in Inhomogeneous Colloidal Suspensions: an Irving-Kirkwood Extension*
Authors: Sun Zong-Li , Kang Yan-Shuang , Kang Yan-Mei 
Published: July 2019

Abstract

Based on statistical mechanics for classical fluids, general expressions for hydrodynamic stress in inhomogeneous colloidal suspension are derived on a molecular level. The result is exactly an extension of the Iving-Kirkwood stress for atom fluids to colloidal suspensions where dynamic correlation emerges. It is found that besides the inter-particle distance, the obtained hydrodynamic stress depends closely on the velocity of the colloidal particles in the suspension, which is responsible for the appearance of the solvent-mediated hydrodynamic force. Compared to Brady’s stresslets for the bulk stress, our results are applicable to inhomogeneous suspension, where the inhomogeneity and anisotropy of the dynamic correlation should be taken into account. In the near-field regime where the packing fraction of colloidal particles is high, our results can reduce to those of Brady. Therefore, our results are applicable to the suspensions with low, moderate, or even high packing fraction of colloidal particles.
decay in supersymmetry with R-parity violation *
Authors: Wang Dong-Yang , Yang Ya-Dong , Yuan Xing-Bo 
Published: July 2019

Abstract
In past years, several hints of lepton flavor universality (LFU) violation have emerged from the

and

data. More recently, the Belle Collaboration has reported the first measurement of the

longitudinal polarization fraction in the

decay. Motivated by this intriguing result, along with the recent measurements of

and

polarization, we present the study of

decays in supersymmetry (SUSY) with

-parity violation (RPV). We consider

,

,

and

modes and focus on the branching ratios, LFU ratios, forward-backward asymmetries, polarizations of daughter hadrons, and the

lepton. The RPV SUSY was capable of explaining the

anomalies at the

level, after taking into account various flavor constraints. In the allowed parameter space, the differential branching fractions and LFU ratios are largely enhanced by the SUSY effects, especially in the large dilepton invariant mass region. Moreover, a lower bound

10−6 is obtained. These observables could provide testable signatures at the high-luminosity LHC and SuperKEKB, and correlate with direct searches for SUSY.
Neutral regular black hole solution in generalized Rastall gravity *
Authors: Lin Kai , Qian Wei-Liang 
Published: July 2019

Abstract
We investigate the static, spherically symmetric regular black hole solutions in the generalized Rastall gravity. In particular, the prescription of Rastall gravity implies that the present approach does not necessarily involve nonlinear electrodynamics. Subsequently, the resulting regular black hole solutions can be electrically and magnetically neutral. The general properties of the regular black hole solutions are explored. Moreover, specific solutions are derived and discussed, particularly regarding the parameter related to the degree of violation of the energy-momentum conservation in the Rastall theory.
Nearby dark matter subhalo that accounts for the DAMPE excess *
Authors: Zhao Yi , Bi Xiao-Jun , Lin Su-Jie , Yin Peng-Fei 
Published: July 2019

Abstract
The precise spectrum of electrons and positrons at high energies plays an important role in understanding their origin. DArk Matter Particle Explorer has reported their first measurement of the

spectrum from 25 GeV to 4.6 TeV. This spectrum reveals a tentative peak at ~1.4 TeV, which requires a nearby source of

. In this work, we study the properties of a large nearby dark matter subhalo that accouns for this spectral peak, such as its mass and distance from Earth, for different concentration models. We compare spectra of the sources in 3FGL with that from DM annihilation in the subhalo, and find ten candidates that have comparable gamma-ray spectra. However, according to the N-body simulation, the probability that such a large subhalo is close enough to Earth is less than 0.1%.
Internal gravity waves from a moving source: modeling and asymptotics
Authors: Bulatov V V , Vladimirov Yu V 
Published: July 2019

Abstract
In this paper we investigated the far internal gravity waves fields excited by a source of disturbances, moving in an infinite vertically stratified medium. The propagation of waves in an inviscid incompressible medium with an exponential distribution of unperturbed density is considered. In the linear approximation and the Boussinesq approximation, uniform asymptotics of the excited internal gravity waves fields were constructed far from the moving source of perturbations. Wave fields in the vicinity of the traverse plane and the horizon of motion are investigated. The obtained asymptotic solutions make it possible to effectively calculate the main amplitude-phase characteristics of the excited far internal gravity waves fields of under certain generation regimes. Analytical solutions allow to qualitatively analyze the solutions obtained. This is important for the correct formulation of more complex mathematical models of the wave dynamics of real natural stratified medium.
Wave dynamics and vortex formation under the impact of a spherical impulse on the boundary between gas and aqueous foam
Authors: Bolotnova R Kh , Gainullina E F 
Published: July 2019

Abstract
The process of interaction of air shock-wave pulse and protective aqueous foam barrier in two-dimensional axisymmetric formulation using two-phase model of gas-liquid mixture including the laws of conservation of mass, momentum and energy for each phase is numerically investigated. The numerical implementation of the model is carried out using the twoPhaseEulerFoam solver of the OpenFOAM package. The results are presented in the form of spatial distributions of pressure fields, velocities and streamlines. The causes and dynamics of toroidal vortices formation in gas are investigated.
Modeling of the optimal scenario of arteriovenous malformation embolization
Authors: Cherevko A A , Gologush T S , Petrenko I A , Ostapenko V V 
Published: July 2019

Abstract
Cerebral arteriovenous malformation is a congenital developmental pathology of cerebral vessels, in which the arterial and venous blood vessels are connected directly by randomly interlaced degenerate vessels. This is a dangerous disease affecting the functioning of the brain, at which the risk of intracerebral hemorrhage is high. One of the methods of treatment of arteriovenous malformation is embolization – endovascular filling of arteriovenous malformation vessels with a special medical embolizing composition for blocking blood flow through them. This method is widely used, but still in some cases accompanied by intraoperative rupture of arteriovenous malformation. In this paper, on the basis of a one-dimensional model of joint two-phase filtration of blood and an embolizing composition, the optimal scenario of embolization is studied from the point of view of safety and efficiency. The methods of admissible and optimal embolization, which reduce the risk of rupture of arteriovenous malformation vessels, are considered.