bluuebunny/crossref_metadata_2025_split huggingface dataset:
Student and Instructor Perceptions and Uses of Artificial Intelligence in Higher Education
Authors: Marshik Tesia , McCracken Christopher , Kopp Bryan , O’Marrah Morgan 
Published: November 2024

Background Artificial intelligence (AI) applications have recently become more powerful and accessible. There has been much discussion about the potential impacts of AI on learning and sample applications. Yet, little research exists on how and to what extent AI is being used in educational contexts. Objective The purpose of this study was to examine and compare students’ and instructors’ perceptions and uses of AI in educational settings. Method A sample of 113 undergraduate students and 71 instructors at a public university completed an online survey in which they reported how and how often they use AI for educational and instructional purposes and their views of its potential benefits and detriments to learning. Results Students and instructors reported relatively low AI usage, similar views on potential benefits and detriments to learning, and similar views on acceptable academic use. However, their perceptions diverged in several important ways. Conclusion This research highlights the need for policy, transparency, training, and nuanced discussions about how to use AI effectively and responsibly to promote learning goals. Teaching Implications The survey instruments developed for this study may be useful tools for facilitating conversations, clarifying expectations, and expanding understanding of AI uses in psychology programs.
The Association of Interleukin 6 Receptor Gene Variant (Rs4129267) with Susceptibility to Ankylosing Spondylitis and Soluble IL-6 Receptor Level in Iranian Patients
Authors: Enayati Samaneh , Akhtari Maryam , Darabi Farideh , Ahmadzadeh Nooshin , Mostafaei Shayan , Vojgani Yousef , Madreseh Elham , Farhadi Elham , Akhlaghi Masoomeh , Jamshidi Ahmadreza , Mahmoudi Mahdi 
Published: November 2024

Objectives: Ankylosing spondylitis (AS) is an axial skeleton-related auto-inflammatory arthritis. Interleukin 6 (IL-6) and its receptor (IL-6R) play a role in the etiopathology of AS. The recent genome-wide association studies (GWASs) revealed that rs4129267; an intrinsic variant of IL6-R is associated with the risk of AS. We aimed to study the rs4129267 IL6R variant in Iranian AS patients and the correlation of this variant with the soluble interleukin-6 receptor (sIL-6R) serum level. Materials and Methods: In this case-control study, we genotyped rs4129267 IL6-R variant in extracted DNA from 498 AS patients and 495 matched healthy controls by Amplification-Refractory Mutation System Polymerase Chain Reaction (ARMS-PCR). The serum level of sIL-6R and IL-6 was also analysed in 39 controls and 42 AS patients by the ELISA method. The correlation between rs4129267 IL-6R variants and patients’ clinical manifestations and sIL-6R level was also investigated. Results: In comparison to the AS individuals, C allele were significantly less prevalent in the healthy control group (OR = 1.23 [1.01 –1.48], P value = .034). Patients had significantly elevated levels of IL-6 serum levels. There was a significant correlation between the presence of the rs4129267 T allele and increased sIL-6R level. Conclusions: Our study confirmed the significant association between the rs4129267 T variant and the protection against AS disease susceptibility. Increased IL-6 level and reduced frequency of sIL-6R rs4129267 T allele in patients which contributes to reduced sIL-6R serum level, highlights the significant role of IL-6 signalling pathway in AS pathogenesis.
A new bithiophene inhibited amyloid-β accumulation and enhanced cognitive function in the hippocampus of aluminum-induced Alzheimer's disease in adult rats
Authors: AbdElRaouf Kholoud , Farrag Hussein SH , El-Ganzuri Monir A , El-Sayed Wael M 
Published: November 2024

Background Alzheimer's disease (AD) is a progressive and irreversible neurological disorder that gradually deteriorates an individual's ability to carry out even the simplest tasks. Objective This study was undertaken to investigate the potential therapeutic efficacy of a novel bithiophene in a rat model of aluminum-induced AD pathology. Methods A total of 108 adult male albino rats weighing 160 ± 20 g, were randomly assigned to six groups: (1) a control group administered DMSO, (2) group receiving a high dose of bithiophene (1 mg/kg), (3) a model group received AlCl3 (100 mg/kg), those rats were then treated by either (4) bithiophene low dose (0.5 mg/kg), (5) high dose (1 mg/kg), or (6) memantine (20 mg/kg). Results Low dose bithiophene treatment was a promising strategy for mitigating oxidative stress and improving synaptic plasticity. This was demonstrated by reductions in malondialdehyde level, and increased activities of superoxide dismutase and catalase, and elevated glutathione content. Likewise, low dose bithiophene enhanced synaptic plasticity through a reduction in excitatory glutamate and norepinephrine levels, while increasing dopamine. Moreover, bithiophene significantly downregulated the expression of GSAP, GSK3- β, and p53, which are implicated in AD progression. This treatment also decreased caspase 3 and amyloid-β (Aβ1–42) accumulation in the hippocampus. Finally, behavioral assessments revealed that low dose bithiophene significantly enhanced learning abilities, as proved by Morris water maze. Conclusions Low dose bithiophene mitigated AD through ameliorating oxidative stress, promoting synaptic plasticity, inhibiting the Aβ accumulation, and enhancing the cognitive functions in a rat model.
Virtual reality interventions and their effects on the cognition of individuals with Alzheimer's disease: A systematic review and meta-analysis
Authors: Santos Vanessa Daudt , Costa Adriana Coelho , Junior Nelson Carvas , Delaere François Jean , Serlet Sebàstien , Dourado Marcia Cristina Nascimento 
Published: November 2024

Background Dementia due to Alzheimer's disease (AD) is the most prevalent neurocognitive disorder in the world and impacts the individual's cognitive functions and functionality in the early stages of the condition. Virtual reality (VR) interventions can assist in non-pharmacological treatment in a more ecological way, positively impacting cognitive abilities. However, there are few studies on VR exclusively involving people with AD in randomized controlled trials. Objective To evaluate the effects of VR intervention on the cognitive functions of people with AD. Methods A systematically conducted search was carried out in MEDLINE, EMBASE, BVS, Web of Science, and Scopus. Eligible studies were randomized controlled trials comparing the efficacy of VR and traditional cognitive interventions in people with AD. Methodologic quality was assessed with the Cochrane risk of bias tool, and outcomes were calculated as risk ratios (for dichotomous outcomes) and mean differences (for continuous outcomes) with 95% confidence interval. Results A total of three randomized controlled trials with 75 participants were included. An improvement in the performance of the VR group was observed in memory, especially when comparing the usual treatment [MD = 0.99; CI95%: 0.33; 1.66; I2 = 0%]. VR has little or no effect on participants’ executive function [MD = 1.36; 95%CI: −1.12; 3.85; I2 = 0%] compared to the usual treatment. Conclusions Our study results cautiously suggest, despite the small number of participants, that VR intervention may be a suitable memory treatment for individuals diagnosed with AD.
A Novel Approach for Monitoring Training Load and Wellness in Women’s College Gymnastics
Authors: Leupold Olivia , Cheng Jennifer , Wimberly Audrey , Nguyen Joseph , Tilley David , Gabbett Tim J. , Casey Ellen 
Published: November 2024

Background: Monitoring training load has the potential to improve sport performance and reduce injuries in athletes. This study examined training load and its association with wellness in artistic gymnastics. Hypotheses: Training load and changes in training load (acute:chronic workload ratio [ACWR]) vary throughout 1 season; wellness is inversely correlated with training load and ACWR. Study Design: Prospective case series. Level of Evidence: Level 3. Methods: A total of 30 female collegiate gymnasts from 4 Division I National Collegiate Athletic Association teams participated (mean age, 20 ± 2 years). During 4 months, before daily training, wellness surveys assessed sleep, energy, soreness, and mood (1-10; higher = better). After daily training, training load surveys assessed training duration per event (warm-up, vault, bars, beam, floor, strength and conditioning) and session rating of perceived exertion (RPE; 1-10; 10 = hardest) per event. Coaches reported technical complexity of training per event (1-4; 4 = hardest). Training load was calculated as [duration] × [RPE] × [technical complexity]. ACWR represented a ratio between acute [1-week] and chronic [4-week rolling average] training loads. Results: ACWR and weekly training load fluctuated throughout the season (ACWR mean weekly range: 0.68-1.11; training load mean weekly range: 2073-6193 arbitrary units). ACWR and weekly training loads were trichotomized into low, medium, and high groups; positive correlations were observed between each wellness variable and ACWR ( P < 0.01) and between each wellness variable and weekly training load ( P < 0.01). Conclusion: Our novel training load monitoring framework for women’s college gymnastics enabled us to characterize training load and its relationship with wellness throughout 1 season. This method should be explored in gymnasts across various ages and competitive levels. Clinical Relevance: This study proposes a framework and the initial findings of monitoring training load and wellness in collegiate women’s gymnastics.
A “food for special medical purposes” for the treatment of intestinal insufficiency/deficiency
Authors: Cava E. , Paolini B. , Martinelli B. , Anzolin F. , Pintus S. , Rahimi F. , Vincenzi M. , Bagnato C. , Lagattolla V. , Grandone I. , Carbonelli M.G. 
Published: November 2024

Background: Insufficient absorption of nutrients from food can be caused by impaired digestion, absorption or transport of nutrients, and can affect macronutrients, micronutrients, or both. Objective: The aim of this multicentric retrospective observational study is to confirm the efficacy of a formula (Bariatrifast, BIOITALIA S.r.l., Italy), supplementing vitamins and minerals, in patients with intestinal insufficiency from multiple different aetiologies, excluding bariatric surgery. Methods: A total of 78 patients were enrolled, assessing anthropometrics, blood pressure, and blood tests at baseline, 2, 4 and 6 months. Bariatrifast was the only supplement assumed. Mean age and BMI were 55.7 years and 23.4 kg/m2. Results: The study shows preliminary results of 20.6% and 52.9% of patients completing 6 and 4-month follow-up: increase of red blood cells and haemoglobin; a trend to increase over time for ferritin and iron; stable leukocytes, platelets and folate; a modest downward trend of transferrin; Vitamin-D improved remarkably then stabilized; mean values of heart rate and systolic-diastolic blood pressure remained stable. No undesirable effects were reported. Conclusions: In conclusion preliminary results suggest that using Bariatrifast in patients with intestinal insufficiency can improve the haematological panel, increasing Vitamins B12 and D, iron and ferritin, therefore confirming the efficacy of this special medical purpose food in intestinal insufficiency.
Knowledge, attitude, and diabetes self-care among individuals at high-risk of diabetes-related blindness in Bangladesh: a cross-sectional study
Authors: Pardhan Shahina , Islam Md. Saiful , Sapkota Raju 
Published: November 2024

Abstract
Background/Aim
Adequate knowledge, attitude, and self-care practice (KAP) are paramount in reducing diabetes complications. This study examined diabetes-related KAP in individuals who have been previously reported to be at a higher risk of blindness such as those on insulin treatment or with a longer (>6 years) duration of diabetes in Bangladesh.

Methods
Six hundred community-dwelling individuals (mean age = 52.7±11.6 years) who had been diagnosed with diabetes by their doctor were interviewed. A semi-structured questionnaire obtained self-reported information about diabetes-related KAP, duration, treatment of diabetes, and sociodemographic parameters including age, gender, and education level. Data were collected using a purposive sample technique and analyzed using Fischer’s exact test or independent samples t-tests.

Results
There were 271 males (45.2%) and 329 (54.8%) females. Of the total participants (mean diabetes duration = 6.6±6.2 years), 36.5% had diabetes for more than the median duration of 6 years, 80.7% were receiving insulin or insulin combined with tablets (insulin group) and the remaining 19.3% were on tablet only and/or diet control (non-insulin group). One-fifth (19.8%) of all the participants did not consider diabetes a serious disease, 31.3% were unaware that uncontrolled diabetes can cause blindness, 40.5% had never had their eyes tested for diabetic retinopathy and 41.5% stated that they would not attend diabetic retinopathy screening until their eyesight became worse. Among those in the insulin group, 42.1% reported being unaware that smoking may be harmful to diabetes compared to 30.2% of those in the non-insulin group (p= 0.02). Additionally, 64.7% of those in the insulin group were unaware that a diabetic retinal screening is different from a routine eye test for spectacles, compared to 44.8% in the non-insulin group (p< 0.001). Sixty-two percent of participants with diabetes duration of more than 6 years reported that diabetes management was a shared responsibility between the doctor and the patient compared to 48.3% with a shorter duration (p< 0.001). Those with a longer duration of diabetes (>6 years) also reported forgetting to take their medication more often than those with a shorter duration (p = 0.02). Twenty-one percent of participants with a duration of diabetes longer than six years had checked their eyes within the previous year compared to 63.5% of those with a shorter duration of diabetes (p< 0.001).

Conclusion
Individuals on insulin treatment demonstrated poorer knowledge and awareness of diabetes and diabetes eye screening. Those with a longer diabetes duration exhibited poorer self-care practices, particularly not taking the medication regularly, and neglecting diabetic retinal checkups. These issues need to be addressed in designing targeted educational interventions to prevent blindness from uncontrolled diabetes in the high-risk groups in Bangladesh.
Decolonization in sexual and reproductive health research methods: a scoping review
Authors: Stevens-Uninsky Maya , Barkhad Aisha , MacDonald Tonya , Perez Alexander , Mbuagbaw Lawrence 
Published: November 2024

Abstract
Background
As researchers and practitioners in the field of global health continue to acknowledge the ongoing impact of colonialism in their work, the call for decolonized research has increased. This has particular relevance in the field of sexual and reproductive health. Despite this recognized need, there is no singularly agreed upon definition of what it means to conduct decolonized research using decolonized methodologies. The aim of this review is to explore the approaches and methodologies used in contemporary sexual and reproductive health research aligned with decolonized systems of thinking.

Methods
This review was developed and conducted in accordance with the JBI and the Extension for Scoping Reviews (PRISMA-ScR) Checklist. In January 2023, Medline (Ovid), Embase, EMCare, Global Health Database, and Web of Science were systematically searched for relevant studies. Relevant grey literature was also scanned. The screening and data extraction were conducted by four independent reviewers using an iterative approach. The findings were analyzed to uncover shared characteristics between the studies.

Results
A total of 1775 articles were retrieved through our search strategy, of which 35 were included as discussing sexual health topics, and representing the principles of decolonization. Few of the included articles explicitly self-identified as decolonized literature. Common themes between studies included that most of the data collection was conducted in high-income countries, largely in North America, and the most prevalent sexual health topics were HIV/AIDs, and STIs/STDs. Most studies were qualitative, used community-based methodologies, and included some form of community advisory board.

Conclusions
This scoping review identifies shared characteristics of both successes and gaps in decolonized research that may inform the methodological processes of future researchers. It emphasizes the need for more decolonized research originating in low- and middle-income countries, as well as decolonization of quantitative research methodologies. The findings also emphasize the importance of community engagement throughout the research process. A shared definition of decolonization is necessary to codify this body of work. Future researchers should focus on clearly communicating their approach in the methodology so that it can be replicated and become part of a shared definition.
International Registered Report Identifier (IRRID): DERR1-10.2196/45771
Leaving the Norwegian opioid maintenance treatment program - patient experiences
Authors: Nesvåg Sverre , Bergqvist Per , Dahlberg Ingrid Elin , McKay James R. 
Published: November 2024

Abstract
Background
Opioid maintenance treatment (OMT) saves lives and makes it possible to start a process of health and social rehabilitation. Previous research shows that those who leave OMT after years of a drug free life and a reasonable level of health and social rehabilitation can have a good chance of living a stable drug free life after leaving the treatment. The aim of this study was to gain more knowledge about how patients who were in the process of leaving, or who had left OMT, experienced the leaving process.

Methods
The study was based on a thematic analysis of transcripts from individual in-depth interviews with 24 patients who had experience with leaving the Norwegian OMT program. Results: The participants in this study had a strong motivation to endure a demanding substitution medication tapering process and leave the OMT program. The tapering benefited strongly from adaptive routines based on ongoing dialog between patients and service providers throughout the process, based on individualized goals and patient experiences each step on the way. The participants had varied experiences regarding the quality and relevance of the support and meeting the need for further treatment and services.

Conclusions
Given a high level of rehabilitation and good support, this study shows that some OMT program patients are in a good position to successfully leave the OMT program or continue the substitution treatment on a low dosage in a less OMT program-dominated life.
Medical liability claims in gynaecologic care: retrospective analysis of claims related to gynaecology in the Netherlands (2005–2022) – Is there a connection between treatment indication, phase of treatment and the risk of medical malpractice claims?
Authors: Klemann Désirée , Hoopen Rankie ten , Mertens Helen , van Merode Frits 
Published: November 2024

Abstract
Background
An increased interest in medical liability claims has been noticed. Nevertheless, detailed data on subject of claims and possible factors that contribute to litigation and indemnity payments are scarce and relatively dated. Insight into these data may provide valuable information to prevent both incidents and malpractice claims.

Objective
To analyse the subject, outcome and costs of malpractice claims related to gynaecological care and their connection with treatment indications and treatment phases.

Design
A retrospective analysis of malpractice claims related to gynaecology.

Setting
All claims related to gynaecology, filed and closed by Netherlands’ largest liability insurance company, Centramed between 2005 and 2022.

Sample
N = 382.

Methods
An in-depth analysis of claim files was performed.

Results
A total of 68.6% of the claims were related to perioperative incidents. A total of 88.0% of all claims were related to treatments with a benign indication and only 12.0% were related to malignancies. The share of malignant treatment indications was high for claims related to diagnostic incidents (37.9%), compared to 7.3% for claims related to surgical treatment. Liability was accepted in 22.5% of all claims. The total costs of all claims amount €6,6mlj. Besides the indication for treatment, deficient expectation management (a lack of informed consent) contributes to dissatisfaction and increases the risk of malpractice claims. Finally, an inadequate medical file compromises legal defence and influences the judgement and settlement of malpractice claims.

Conclusions
There is a connection between treatment indications and treatment phases and the risk of malpractice claims and their outcome.
Survey of Massachusetts peer recovery coaches’ attitudes toward the use of psychedelics to treat substance use disorders
Authors: Szpak Veronica , Kim Amanda , Sager Zachary , Suzuki Joji 
Published: November 2024

Abstract
Background
There has been a growing interest in the use of psychedelics for therapeutic purposes. However, there is a lack of research on peer recovery coaches' attitudes toward the use of psychedelics for SUD treatment. Therefore, we conducted a survey of peer recovery coaches in Massachusetts to gain insight into their attitudes toward the use of psychedelics to treat SUDs.

Methods
Peer recovery coaches in Massachusetts were invited to participate in an online survey between August and October 2023. The survey collected respondents’ demographics, socioeconomic characteristics, personal substance use history, opinions on psychedelics for addiction treatment, and spiritual experiences.

Results
146 individuals completed the survey. The mean age was 48.7 years (SD 11.2), 61% identified as female, 74% were employed as peer recovery coaches, and 43% were Certified Addiction Recovery Coaches (CARC). 70.7% reported utilizing 12-step programs, and 76% reported having a personal history of using psychedelics. The majority of participants agreed that they would feel comfortable being a coach for someone using psychedelics to treat SUDs. However, a significant number of participants expressed concerns. Those who had utilized 12-steps were more likely to express concerns about the dangers of using psychedelics to treat SUD. Conversely, participants with a personal history of psychedelic use were more likely to support the use of psychedelics for the treatment of SUDs.

Conclusions
While peer recovery coaches express support for using psychedelics to treat SUD, they also voice concerns about the potential risks.