bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tau pathway‐based gene analysis on PET identifies CLU and FYN in a Korean cohort
Authors: Yi Dahyun , Byun Min Soo , Park Jong‐Ho , Kim Jong‐Won , Jung Gijung , Ahn Hyejin , Lee Jun‐Young , Lee Yun‐Sang , Kim Yu Kyeong , Kang Koung Mi , Sohn Chul‐Ho , Liu Shiwei , Huang Yen‐Ning , Saykin Andrew J. , Lee Dong Young , Nho Kwangsik ,   for the KBASE research group
Published: December 2024

AbstractINTRODUCTIONThe influence of genetic variation on tau protein aggregation, a key factor in Alzheimer's disease (AD), remains not fully understood. We aimed to identify novel genes associated with brain tau deposition using pathway‐based candidate gene association analysis in a Korean cohort.METHODSWe analyzed data for 146 older adults from the well‐established Korean AD continuum cohort (Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease; KBASE). Fifteen candidate genes related to both tau pathways and AD were selected. Association analyses were performed using PLINK: A tool set for whole‐genome association and population‐based linkage analyses (PLINK) on tau deposition measured by 18F‐AV‐1451 positron emission tomography (PET) scans, with additional voxel‐wise analysis conducted using Statistical Parametric Mapping 12 (SPM12).RESULTSCLU and FYN were significantly associated with tau deposition, with the most significant single‐nucleotide polymorphisms (SNPs) being rs149413552 and rs57650567, respectively. These SNPs were linked to increased tau across key brain regions and showed additive effects with apolipoprotein E (APOE) ε4.DISCUSSIONCLU and FYN may play specific roles in tau pathophysiology, offering potential targets for biomarkers and therapies.Highlights
Gene‐based analysis identified CLU and FYN as associated with tau deposition on positron emission tomography (PET).
CLU rs149413552 and FYN rs57650567 were associated with brain tau deposition.
rs149413552 and rs57650567 were associated with structural brain atrophy.
CLU rs149413552 was associated with immediate verbal memory.
CLU and FYN may play specific roles in tau pathophysiology.
CO‐Tolerant Heterogeneous Ruthenium Catalysts for Efficient Formic Acid Dehydrogenation
Authors: Xue Guangxin , Jiao Yueyue , Li Xiang , Lin Tian , Yang Caoyu , Chen Sihan , Chen Zupeng , Qi Haifeng , Bartling Stephan , Jiao Haijun , Junge Henrik , Beller Matthias 
Published: December 2024

AbstractThe development of improved and less costly catalysts for dehydrogenation of formic acid (HCOOH) is of general interest for renewable energy technologies involving hydrogen storage and release. Theoretical calculations reveal that ruthenium (Ru) nanoparticles supported on nitrogen‐doped carbon should be appropriate catalysts for such transformations. It is predicted that nitrogen doping significantly decreases the formation of CO, but at the same time increases CO tolerance of the catalysts. To prove these hypotheses heterogeneous ruthenium catalysts supported on porous nitrogen‐doped carbon (Rux/CN) with hierarchical structure were synthesized using carbon nitride (C3N4) as template and phenanthroline (Phen) as ligand. Experimental tests in HCOOH dehydrogenation revealed that the optimal catalyst Ru7/CN exhibited good thermal stability at 140 °C and a high turnover frequency (TOF >1300 h−1), which is more than one order of magnitude higher than that of the commercial Ru5/C catalyst.
Transition Metal as Template: Reversing the Synthesis Logic in the Preparation of Pincer Complexes
Authors: Contreras Jovanny J. , Lee Samuel R. , Nguyen Vinh T. , Suarez Thomas , Leong Derek W. , Bhuvanesh Nattamai , Johnson Miles W. , Ozerov Oleg V. 
Published: December 2024

AbstractThe conventional synthetic approach to transition metal pincer complexes calls for the preparation of the tridentate pincer (pro)ligand first, with subsequent introduction of the transition metal center as the last step. This work demonstrates that the alternative synthetic logic, where the central main group element is introduced last, can be applicable to a number of PEP pincer complexes (E=B, Al, Si, P) derived from phosphinophenols and phosphinopyrroles. This approach obviates the need to isolate well‐behaved propincer precursors, and instead relies on the formation of phosphine‐metal adducts first, whose nature determines the stoichiometry of the needed main group reagent to complete the synthesis.
Suppressing Exciton–Vibration Coupling via Intramolecular Noncovalent Interactions for Low‐Energy‐Loss Organic Solar Cells
Authors: Gu Xiaobin , Wei Yanan , Zeng Rui , Lv Jikai , Hou Yuqi , Yu Na , Tan Senke , Wang Zaiyu , Li Congqi , Tang Zheng , Peng Qian , Liu Feng , Cai Yunhao , Zhang Xin , Huang Hui 
Published: December 2024

AbstractMinimizing energy loss is crucial for breaking through the efficiency bottleneck of organic solar cells (OSCs). The main mechanism of energy loss can be attributed to non‐radiative recombination energy loss (ΔEnr) that occurs due to exciton–vibration coupling. To tackle this challenge, tuning intramolecular noncovalent interactions is strategically utilized to tailor novel fused ring electron acceptors (FREAs). Upon comprehensive analysis of both theoretical and experimental results, this approach can effectively enhance molecular rigidity, suppress structural relaxation, reduce exciton reorganization energy, and weakens exciton–vibration coupling strength. Consequently, the binary OSC device based on Y‐SeSe, which features dual strong intramolecular Se ⋅ ⋅ ⋅ O noncovalent interactions, achieves an outstanding power conversion efficiency (PCE) of 19.49 %, accompanied by an extremely small ΔEnr of 0.184 eV, much lower than those of Y‐SS and Y‐SSe based devices with weaker intramolecular noncovalent interactions. These achievements not only set an efficiency record for selenium‐containing OSCs, but also mark the lowest reported ΔEnr value among high‐performance binary devices. Furthermore, the ternary blend device showcases a remarkable PCE of 20.51 %, one of the highest PCEs for single‐junction OSCs. This work demonstrates the effectiveness of intramolecular noncovalent interactions in suppressing exciton–vibration coupling, thereby achieving low‐energy‐loss and high‐efficiency OSCs.
Probing the Hidden Photoisomerization of a Symmetric Phosphaalkene Switch
Authors: Deka Rajesh , Steen Jorn D. , Hilbers Michiel F. , Roeterdink Wim G. , Iagatti Alessandro , Xiong Ruisheng , Buma Wybren Jan , Di Donato Mariangela , Orthaber Andreas , Crespi Stefano 
Published: December 2024

AbstractIn this study, we present the synthesis and analysis of a novel, air‐stable, and solvent‐resistant phosphaalkene switch. Using this symmetric switch, we have demonstrated degenerate photoisomerization experimentally for the first time. With a combination of photochemical‐exchange NMR spectroscopy, ultrafast transient absorption spectroscopy, and quantum chemical calculations, we elucidate the isomerization mechanism of this symmetric phosphaalkene, comparing it to two other known molecules belonging to this class. Our findings highlight the critical role of the isolobal analogy between C=P and C=C bonds in governing nanoscale molecular motion and break new ground for our understanding of light‐induced molecular processes in symmetric heteroalkene systems.
High‐Entropy Zeolitic Imidazolate Frameworks for Dynamic Hydrogen Isotope Separation
Authors: Nam Joohan , Cho Changhyeon , Jung Sungyeop , Jung Minji , Kim Yeongjin , Hong Yejin , Lee Sohyeon , Oh Hyunchul , Choe Wonyoung 
Published: December 2024

AbstractEntropy‐driven strategy enables the systematic design of complex systems by using entropy as a quantifiable design parameter for the degree of mixing. In this study, we present mixed‐linker zeolitic imidazolate frameworks (ZIFs), sod‐ZIF‐1 series, that features two types of six‐membered rings (6MRs) with aperture sizes of 3.4 Å and 1.7 Å. By adjusting the configurational entropy, the ratio of these 6MRs can be systematically controlled, which significantly influences adsorptive properties, particularly improving the H2 affinity about 3 times throughout the series. This results in the significant enhancement of retention times in dynamic separation of hydrogen isotopes (D2/H2), even over LNG liquefaction temperature. This approach to entropy‐driven pore engineering provides new opportunities for enhancing gas adsorption and separation processes.
A Tetrazine Amplification System for Visual Detection of Trace Analytes via Click‐Release Reactions
Authors: Li Jing , Cheng Mingxin , Zhang Hongbo , Wang Yichen , Guo Weiwei , Zheng Yueqin 
Published: December 2024

AbstractAchieving visual detection of analytes at ultra‐low concentrations in complex mixtures remains a persistent challenge. While sophisticated techniques offer single‐molecule sensitivity, practical hurdles remain, necessitating tailored signal amplification systems for direct visual detection. In this study, we develop a strategy for the visualized detection of tetrazine through a “click‐release‐oxidation‐cycle” (CROC) cascade amplification process. We systematically describe the construction and synthesis of this system, the kinetic process of click release, the kinetics of oxidation to tetrazine and its cascade amplification effect in trace amounts of tetrazine. This system is capable of amplifying the signal of tetrazine at a concentration as low as 2 nM by 105‐fold, thereby providing a clearly visible purple signal. Finally, as proof of concept, we successfully apply this method to visually detect trace β‐galactosidase (β‐gal) and Pd2+.
Multi‐Electron Transfer Halide Cathode Materials Based on Intercalation‐Conversion Reaction Towards All‐Solid‐State Lithium Batteries
Authors: Zhou Xu , Jiang Ming , Duan Yuhao , Jia Zhenghao , Yuan Cheng , Feng Kai , Fu Qiang , Zhang Liang , Yang Xiaofei , Li Xianfeng 
Published: December 2024

AbstractAll‐solid‐state lithium batteries (ASSLBs) with non‐flammable solid‐state electrolytes offer high energy density and enhanced safety. However, their energy densities are greatly limited by low‐capacity and low‐ionic‐conductivity oxide cathode materials, typically relying on the intercalation‐deintercalation mechanism with a catholyte content of 15–30 wt %. Here we introduce the LixFeXx+2 (X=Cl, Br) families as high‐capacity and high‐ionic‐conductivity alternatives, operating via a 3 mol e− transfer intercalation‐conversion coupling reaction. Notably, the catholyte‐free ASSLBs using 95 wt % LiFeCl3 active material delivers a remarkable capacity of 446 mAh g−1 and a high energy density of 912 Wh kg−1, which surpasses most oxide cathode materials. Of particular interest is the formation of amorphous Fe during the conversion process. The amorphous Fe exhibits high activity, catalyzing the conversion of LiX back to LixFeXx+2, which proves instrumental in realizing reversible intercalation‐conversion reactions. These halide cathode materials represent a significant advancement towards high‐energy‐density ASSLBs.
Tillandsia‐Inspired Asymmetric Covalent Organic Framework Membranes for Unidirectional Low‐Friction Water Collection
Authors: Yao Jiaao , Zuo Hongyu , Bi Jingjie , Liu Yanjun , Wu Huiqing , Yuan Jiayin , Chen Yiwang , Liao Yaozu , Zhang Weiyi 
Published: December 2024

AbstractFriction plays a pivotal role in many phenomena of physical chemistry and has long been in the focus of research thereof. As a crucial parameter, friction in membranes’ inner and/or outer surface can be minimized to reduce solvent inlet resistance and enlarge inner pore fluid flux, ideally reaching near frictionless transport of water at nanoscale. Inspired by the leaf structure of Tillandsia, a porous membrane with a rough surface and a hydrophilic inlet together with hydrophobic pore channels was designed and fabricated, based on covalent organic frameworks (COFs). Combined with COFs’ inherent highly oriented pore structures, the as‐made asymmetric membranes through chemical etching can minimize the solvent critical intrusion pressure and enable inner pore low friction water transport. Ultimately, obtained COF membranes succeeded in trapping fog from air and achieved a water harvesting rate (WHR) of 1570 mg cm−2 h−1, together with small molecular pollutants filtrated off in the meantime. Intriguingly, the synthesized asymmetric COF membranes illustrated unidirectional low friction water collecting and transporting features, the successful imitation of T. macdougallii. This work presents a practical strategy to construct functional porous membranes for low friction water collection and transport, and created a model paradigm to design fluid transporting pore channels.
Insights Into the Thermal Stability and Proton Transport Mechanism of PTFE‐Nafion Composite Membranes
Authors: Zeng Sixiu , Zeng Yuexi , Song Jiangping , Meng Zihan 
Published: December 2024

ABSTRACTThe controllable design of proton exchange membranes (PEMs) with outstanding temperature resistance and efficient proton conduction is essential for high‐temperature PEM fuel cells. In this study, a polytetrafluoroethylene (PTFE)‐Nafion composite PEM was prepared using immersion and high‐temperature heat treatment methods. To understand the thermal stability, the glass transition temperatures of the PTFE‐Nafion and Nafion membranes were tested using static thermomechanical analysis. The PTFE‐Nafion membrane had a higher glass transition temperature than the Nafion membrane. In terms of the microstructure, the PTFE‐Nafion composite membrane exhibited a slightly larger ion domain structure than the Nafion membrane, and the first scattering peak of the PTFE‐Nafion composite membrane appeared at q ≈ 0.018 nm−1, while the pure Nafion membrane peak was located at q ≈ 0.022 nm−1. The PTFE‐Nafion composite membrane also exhibited higher proton conductivity than the Nafion membrane, and the activation energy of the Nafion membrane was approximately 3.5 times higher than that of the PTFE‐Nafion composite membrane. These results demonstrated the difference in proton transport mechanism for the PTFE‐Nafion composite and pure membranes, which may help guide the rational design of PEMs for fuel cells operating in high‐temperature and low‐humidity environments.
Plankton as an Evaluation Tool for Ecosystem Conservation: A Study Involving Different Habitats Associated With the Salado River in the Pampa Region of Argentina
Authors: Alvarez M. Fernanda , Solari Lía C. , Küppers Gabriela C. , Gabellone Néstor A. , Benítez Hernán H. , Vojkovic Matilde , Claps M. Cristina 
Published: December 2024

ABSTRACTFreshwater biodiversity is declining sharply. The conservation of these biodiverse habitats has generally depended on their designation as protected areas, but specific groups such as plankton tend to be overlooked. The Salado River (Argentina) constitutes a highly characteristic morphologic feature of the pampas, having a basin of 150,000 km2. The Las Flores system, particularly, is key in the development of the river, and the presence of two tributaries adds landscape heterogeneity with habitats such as shallow lakes, backwater ponds and wetlands. Our aim in this work was thus to evaluate the Salado River conservation status by measuring the specific richness of its planktonic community in order to argue for the Salado's establishment as a protected reserve. An analysis of the phytoplankton and zooplankton assemblages after several years of sampling in the river, streams and backwater ponds indicated that habitat heterogeneity increased the diversity of the region and that sites such as backwater ponds or streams were critical for the functioning of the river system as a whole through adding particular species or acting as species reservoirs. This supports habitat fragmentation in the area, which combined with environmental heterogeneity contributed to high ß diversity values. However, such separation also involves a trade‐off because prolonged isolation between subsystems can result in net species loss. Finally, the present work focused on the significance of biodiversity at the landscape level, with planktons as a model for the conservation of a principal site in one of the main rivers of Argentina.
Insight into the Metal‐Free Reduction of Isocyanates to N‐Methyl Anilines at Room Temperature
Authors: Nad Pinaki , Kisan Hemanta K. , Mukherjee Arup 
Published: December 2024

AbstractA simple and sustainable protocol has been developed to reduce isocyanates to the N‐methyl anilines under metal‐free conditions. The reaction proceeds with BF3 ⋅ OEt2 as a catalyst and ammonia borane as a hydrogen source in THF at room temperature, leading to the formation of a wide range of substituted aniline derivatives. Control experiments and deuterium labeling studies were performed to understand the mechanism of the present procedure. A detailed computational study was also conducted to shed light on the possible mechanism and free energies of the intermediates and transition states involved in this present protocol.
Applications of a biocompatible alginate/pericardial fluid‐based hydrogel for the production of a bioink in tissue engineering
Authors: Sönmezer Açıkgöz Dilek , Latifoğlu Fatma , Toprak Güler , Baran Münevver 
Published: December 2024

AbstractEnhancing the biocompatibility of biomaterials is a critical aspect of tissue engineering and regenerative medicine. Advances in 3D bioprinting technology, blending natural and synthetic materials for the production of bioink, offer new opportunities to develop highly biocompatible materials that can closely mimic the native tissue environment. In this study, we used pericardial fluid structure (PFS)‐based material together with alginate to mimic the extracellular matrix (ECM) and produce a bioink material. Thus, blended alginate with PFS material and MC3T3‐E1 pre‐osteoblast cell‐laden hydrogels characterized by comparing each other, especially alginate hydrogels, and evaluated in terms of biocompatibility for tissue engineering applications. According to the rheological analysis results, all hydrogel groups A, A‐PFS (150 mg), and A‐PFS (1:1) had viscoelastic properties. Mechanical tests showed that the A‐PFS (1:1) hydrogel had the most strength properties. Additionally, the viscosity values of the hydrogel solutions were in an applicable range for use in 3D bioprinters. It was also found out that PFS increased the biocompatibility of alginate‐based bioink, in terms of cell proliferation and differentiation. Overall, these findings suggest that alginate and pericardial fluid‐based materials can be successfully used for bioink production. The resulting hydrogels exhibit viscoelastic properties, appropriate viscosity for 3D bioprinting, and support cell viability, proliferation, and osteogenic differentiation. This research has the potential not only to produce bioink but also to produce injectable hydrogels and drug delivery systems, which can become biocompatible materials that can be used for tissue engineering and regenerative medicine applications.
Ionizable cationic lipid nanoparticles loaded with miRNA‐125b/BLZ945 for pancreatic cancer treatment
Authors: Zhang Jiajie , Qu Ming , Mo Zhanhao , Sui He , Liu Lin , Fu Deliang 
Published: December 2024

AbstractIn prior research, both miRNA‐125b and BLZ945 have shown potential in effectively inhibiting M2 macrophage polarization and producing antitumor effects. Nevertheless, their physicochemical characteristics present significant challenges for efficient in vivo delivery. Ionizable cationic lipid nanoparticles (LNPs), recognized for their superior biocompatibility and drug‐loading capacity, serve as a novel carrier for nucleic acid‐based therapeutics. In our study, we successfully encapsulated both agents within LNPs and conducted a thorough characterization. Subsequently, we investigated their potential to repolarize M2 macrophages in vitro and evaluated their in vivo distribution, biosafety, and antitumor efficacy. The findings revealed that the LNPs maintained excellent drug‐loading efficiency, consistent particle size, and stable zeta potential. All formulations effectively inhibited M2 macrophage polarization in vitro. Upon administration in vivo, the LNPs not only demonstrated favorable biosafety profiles but also accumulated efficiently in tumor tissues, substantially reducing tumor burden, particularly notable in co‐loaded LNPs. Our results affirm that LNPs are an effective carrier for miRNA‐125b and BLZ945, highlighting this encapsulation approach as promising for the treatment of solid tumors and meriting further investigation. Practitioner points: (i) Ionizable cationic nanoparticles provide high and stable encapsulation rates to efficiently load nucleic acid polymers into the LNP, avoiding the rapid accumulation of circulating macrophages, which can lead to reduced penetration of the LNP into target tissues. Therefore, it can be used as a novel drug delivery method to benefit clinical patients. (ii) miRNA‐125b LNP/BLZ945 LNP attenuated the depleting effect of BLZ945 on macrophages and significantly inhibited macrophage M2 polarization. It could be effectively distributed in tumors and showed good biosafety while exerting antitumor effects, bringing hope to clinical pancreatic tumor patients.
Phytotoxic and Antifungal Activity of (−)‐Penienone Produced by Penicillium palitans (Ascomycota) Isolated from Deep Sea Sediments in the Southern Ocean, Maritime Antarctica
Authors: Barreto Debora Luiza Costa , Lowell Cantrell Charles , Karla da Silva Mayanne , Rodrigues de Carvalho Camila , do Nascimento de Queiroz Sonia Claudia , Bajsa‐Hirschel Joanna , Tamang Prabin , Oscar Duke Stephen , Wagner Fernandes Duarte Alysson , Henrique Rosa Luiz 
Published: December 2024

AbstractMetabolites isolated from Penicillium palitans, obtained from deep sea sediments in the maritime Antarctica, were investigated for phytotoxic and antifungal activities. The fungus was submitted to solid state fermentation, and its crude extract was produced. Chromatographic separations of the P. palitans methylene chloride crude extract led to the isolation of two analogous compounds: (−)‐penienone (1) and (−)‐palitantin (2). The phytotoxic activity of these compounds was assessed against seeds of Lactuca sativa and Agrostis stolonifera. Both compounds demonstrated activity exclusively in the monocotyledonous model, A. stolonifera. At a concentration of 1 mg mL−1, (−)‐penienone caused 100 % inhibition of seed germination, while (−)‐palitantin had only moderate activity on germination and growth of seedlings at this concentration after 7 days of treatment. Against Lemna paucicostata, at 57 μM, (−)‐penienone inhibited growth by 50 % (IC50). (−)‐Palitantin was much less active. When evaluated for their antifungal activity against Colletotrichum fragariae, only (−)‐penienone had an IC50 value of 0.3 μM. The strain P. palitans was shown to be a promising source of phytotoxic and antifungal compounds, suggesting that extremophilic fungi, such as wild Penicillium strains from Antarctica, have the potential to yield novel prototype molecules for new pesticide development.