bluuebunny/crossref_metadata_2025_split huggingface dataset:
Achievements and Challenges in Implementing Urban Family Physician Program in Iran: Viewpoint of Managers and Executives
Authors: Kabir Mohammad Javad , Ashrafian Amiri Hasan , Hassanzadeh-Rostami Zahra , Momtahen Reza , Zafarmand Rasoul , Nasrollahpour Shirvani Seiyed Davoud 
Published: September 2019

Background: Urban family physician program is one of the relatively large reforms in Iran's health care system implemented in Fars and Mazandaran provinces since 2012. Nearly five years after implementation of the program, this study aimed to identify the achievements and challenges of this program from the viewpoints of managers and administrators.
Methods: This cross-sectional study was conducted in winter of 2016. The research population included administrators and experts monitoring the urban family physician program and representatives of the family physicians and health care providers selected using the census method. The data collection tool was a two-part researcher-made questionnaire containing 15 questions with confirmed validity. To collect data, 29 panels of experts were held and the collected information was analyzed by SPSS 23 using independent t-tests and ANOVA.
Results: Among the total of 647 participants in 2 provinces, 1540 achievement cases, 2387 challenge cases, and 1641 strategies were found. The average numbers of achievements, challenges, and strategies stated by each person were 2.38 ± 2.0, 3.70 ± 2.7, and 2.54 ± 2.0, respectively. The most frequent achievements, challenges, and strategies were increased disease detection and care (430), untimely payment to physicians (198), and providing sustainable resources for timely payments (119). The means of achievements, challenges, and strategies had significant relationship with some of the individual and social variables (p < 0.05).
Conclusion: This study showed that increasing the rate of detection was the most important achievement and lack of timely payment was the biggest challenge of the program, which should be considered by policy makers.
Analysis of Emergency Department Queue System Performance: Simulation Approach Based on Experiment Design
Authors: Bahari Arman , Asadi Farzaneh 
Published: September 2019

Background: Simulation is an appropriate technique for analyzing and evaluating the dynamic behavior of complex systems. The present study aimed to develop an integrated model using a simulation approach based on designing experiments to analyze performance of the admission queue system of patients, who referred to the emergency department of the Modarres hospital.
Methods: In this descriptive-analytical research, effective variables on resource efficiency empowerment were identified and analyzed using inferential statistics and one-way ANOVA. Later, effects of the effective factors were estimated. Furthermore, performance of the emergency department system was simulated using the Visual Paradigm software. Results obtained from implementation of the simulation model were used as input for designing an experiment. A fully factorial 2-level experiment design was also used with central points. The independent variables studied in the simulation model included practical nurse, emergency secretary, nurse, cardiologist, and hospital bed. The dependent variable was the patients' waiting queue in the studied emergency department.
Results: According to , the acceptable effects were determined based on the results of variance analysis for the model. The value of indicated that 82.35% of the model explains all variability of the response-level data around the mean. Therefore, it can be concluded that the design space was in accordance with the estimated model based on the results of variance analysis.
Conclusion: In the present study, performance analysis of the emergency department queue system was conducted using simulation and experiment design. The nonlinear regression model was able to predict the queue length. Moreover, this model can be used to predict dependent variables considering acceptable factors. According to the results, minimum length of the queue is obtained when the number of emergency secretaries is at a high level and the number of practical nurses and nurses is at a low level.
IMPACT STRATEGIC SOURCING, SUPPLIER INNOVATIVENESS, AND INFORMATION SHARING ON SUPPLY CHAIN AGILITY
Authors: Jermsittiparsert Kittisak , Rungsrisawat Somdech 
Published: September 2019

Purpose: The prime objective of the current study is to explore the nexus between supplier innovativeness, information sharing, strategic sourcing and supply chain agility. The study has tried to investigate the direct impact of supplier innovativeness, information sharing, and strategic sourcing on supply chain agility.
Methodology: In addition to that the current study is also interested in examining the mediating role of information sharing and strategic sourcing in the relationship between supplier innovativeness and supply chain agility. The previous research studies have analysed the influence of supplier innovativeness on the performance of the firm.
Results: It has been revealed through some research studies that there is a positive association among the performance of manufacturers and supplier innovativeness as well as relationship performance. Thus the current study is among the pioneering studies on this issue. Employing the survey-based methodology, the SEM-PLS technique is used to test the hypothesized relationships. So, the current study has used SEM-PLS as a statistical tool to answer the research questions raised in this study and research objectives envisaged in the current study. The findings of the study have provided support to the theoretical foundation and proposed hypothesis of the current study. Current study will be helpful for policymakers and practitioners in understanding the issues related to supply chain risk, supply chain integration and supply chain performance. In the author's knowledge this is among very few pioneering studies on this issue.
José Tudela, Josep María Castell a, Enriqueta Expósito y Mario Kölli ng (eds.). Libro blanco sobre calidad democrática en España. Marcial Pons. Madrid, 2018. 331 pp.
Authors: Fondevila Marón Manuel 
Published: September 2019

Nadie puede ignorar que la influencia que actualmente ejercen los/las Profesores/as de Derecho en el ámbito político-legislativo es muy inferior a la que tenía años atrás. Este no es lugar apropiado para disertar sobre las causas de esta pérdida de espacios de diálogo y encuentro entre ambos mundos, pero sí para indicar que la obra que se presenta resulta idónea para tratar de revertir esta situación. Publicación en línea: 31 julio 2019
Machine Tool Assignment Realized by Automated NC Program Generation and Machining Time Prediction
Authors: Nishida Isamu ,   Kobe University 1-1 Rokko-dai, Nada-ku, Kobe, Hyogo 657-8501, Japan, Shirase Keiichi 
Published: September 2019

The present study proposed a method to automatically generate a numerical control (NC) program by referring to machining case data for each machine tool with only 3D-CAD models of a product and workpiece as the input data, and to select machine tools for machining the target removal region among several machine tools with different characteristics. The special features of the proposed method are described as follows. The removal volume can be automatically obtained from the total removal volume (TRV), which is extracted from the workpiece and product using a Boolean operation by dividing it on the XY plane. The removal region changed according to the determined machining sequence. The conditions for machining the removal region is automatically determined according to the machining case data, which is stored by linking the geometric properties of the removal region with the machining conditions determined by experienced operators. Furthermore, an NC program is automatically generated based on the machining conditions. The machine tools for machining the target region are selected according to the predicted machining time of each machine tool connected by a network.
A case study was conducted to validate the effectiveness of the proposed system. The results confirm that machining can be conducted using only 3D-CAD models as input data. It was suggested that the makespan would be shortened by changing the machining sequence from the optimized machining sequence when machining a plurality of products.
Analisis Ketersediaan Air Meteorologis Untuk Memenuhi Kebutuhan Air Domestik Penduduk di Kabupaten Malang
Authors: Millah Maula Zakiyyatul 
Published: September 2019

Kabupaten Malang merupakan salah satu kabupaten yang terletak di Provinsi Jawa Timur. Perkembangan suatu wilayah akan menyebabkan kebutuhan air terus meningkat seiring dengan bertambahnya jumlah penduduk. Persebaran curah hujan yang tidak merata akibat dari keragaman kondisi fisiografis Kabupaten Malang juga menyebabkan ketersediaan air disetiap wilayah berbeda. Metode yang digunakan dalam penelitian adalah metode deskriptif dengan menggunakan pendekatan kuantitatif. Sampel wilayah yang digunakan dalam penelitian ini adalah tujuh kecamatan yang ada di Kabupaten Malang, yaitu Kecamatan Kalipare, Kecamatan Donomulyo, Kecamatan Pagak, Kecamatan Sumbermanjing Wetan, Kecamatan Jabung, Kecamatan Singosari, dan Kecamatan Lawang.Tujuan penelitian ini adalah menganalisis ketersediaan air meteorologis dan mengalisis kebutuhan air domestik penduduk, serta menganlisis kekeritisan air domestik di Kabupaten Malang. Tahapan penelitian yang dilakukan yakni: 1) Mengumpulkan data yang digunakan dalam penelitian; 2) Melakukan analisis ketersediaan air meteorologis; 3) Melakukan analisis kebutuhan air domestic; 4) Melakukan analisis tingkat kekritisan air; 5) Melakukan survey lapangan; 6) Melakukan pemetaan. Hasil penelitian menunjukkan bahwa ketersediaan air meteorologis tertinggi yaitu di Kecamatan Sumbermanjing Wetan dan ketersediaan air meteorologis terendah yaitu di Kecamatan Lawang, Sedangkan untuk kebutuhan air domestik tertinggi yaitu di Kecamatan Lawang dan kebutuhan air domestik terendah yaitu di Kecamatan Pagak. Wilayah dengan tingkat kekritisan air pada kategori sangat kritis yaitu di Kecamatan Lawang dan Kecamatan Singosari dengan, sedangkan wilayah tingkat kekritisan air pada ketegori tidak kritis yaitu di Kecamatan Donomulyo.
A Time-dependent Genome-Wide SNP-SNP Interaction Analysis of Chicken Body Weight
Authors: Li Fang-Ge , Li Hui 
Published: September 2019

Abstract
Background
The important property of the quantitative traits of model organisms is time-dependent. However, the methodology for investigating the genetic interaction network over time is still lacking. Our study aims to provide insights into the mechanistic basis of epistatic interactions affecting the phenotypes of model organisms.
Results
We performed an exhaustive genome-wide search for significant SNP-SNP interactions associated with male birds’ body weight (n=475) at multiple time points (day of hatch body weight (BW0) and one, three, five and seven weeks (BW1, BW3, BW5, BW7). Statistical analysis detected 67, 4, and 2 significant SNP pairs associated with BW0, BW1, and BW3, respectively, with a significance threshold at 8.67×10 −12 (Bonferroni-adjusted: 1%). Meanwhile, no significant SNP pairs associated with BW5 and BW7 were found. The SNP-SNP interaction networks of BW0, BW1, and BW3 were built and annotated.
Conclusions
With strong annotated information and a strict significant threshold, SNP-SNP interactions underpinned the gene-gene interactions that might occur between chromosomes or within the same chromosome. Comparing and combing the networks, the results indicated that the genetic network for chicken body weight was dynamic and time-dependent.
Germline knockdown of spargel (PGC-1) produces embryonic lethality in Drosophila
Authors: George Jack , Jacobs Howard Trevor 
Published: September 2019

Abstract
Background: The transcriptional co-activators of the PGC-1 family have been proposed as master regulators of mitochondrial biogenesis. Drosophila has a single member of the family, Spargel (srl). Functional studies of srl allow PGC-1 role(s) in development and physiology to be elucidated without the confounding effects of tissue-specificity and redundancy. Spargel was previously shown to govern the expression of genes for mitochondrial functions in the adult fat body.

Results: Here we analysed the role of srl in early development. srl RNA was abundant in ovaries and early embryos but, upon cellularization, fell to low levels where it remained for the rest of development. Knockdown of srl in the female germline resulted in embryonic semilethality, with only ~10% of embryos able to complete development. Embryos from germline srl-knockdown mothers were predominantly small, with the majority suffering a catastrophic derangement of development marked by failure to form a uniform blatstoderm, irregular cell size and chaotic cell movements instead of orderly gastrulation. However, genes whose expression in early embryos depends on localized determinants were expressed normally. The abundance of representative mitochondrial proteins was not decreased in knockdown ovaries or embryos, and their mRNAs were generally increased rather than decreased.

Conclusions: We infer that srl has a more general role in early development, distinct from specifically promoting mitochondrial biogenesis.
Achieving improved health and human rights for street-based sex workers - an ethnographic exploration of factors that drive policing of cisgender female sex workers in a U.S. setting
Authors: Footer Katherine HA , Silberzahn Bradley E. , Lim Sahnah , Huettner Steven , Kumar Victor A. , Loeffler Derek , Peitzmeier Sarah M. , Sherman Susan G. 
Published: September 2019

Abstract
Background: Building on a broader sociological discourse around policing approaches towards vulnerable populations, increasing public health evidence points to policing practices as a key health determinant, particularly among street-based sex workers. Despite the importance of policing as a structural health determinant, few studies have sought to understand the factors that underlie and shape policing practices towards sex workers. This study therefore aimed to explore the drivers for policing attitudes and practices towards street-based cisgender female sex workers.

Methods: Drawing on ethnographic methods, 280 hours of observations with police patrol and 10 stakeholder interviews with senior police leadership in Baltimore City, USA were carried out to better understand the drivers for policing strategies towards cisgender female sex workers. Analysis was data- and theory-driven, drawing on the concepts of police culture and complementary criminological and sociological literature exploring the more explicitly spatial exercise of police discretion and structural forces operating on police decision making.

Results: Ecological factors at the structural (e.g., criminalization), organizational (e.g., violent crime control), community and individual level (e.g., stigmatizing attitudes) emerged as key to shaping individual police practices and attitudes towards cisgender female sex workers in this setting. Findings indicate senior police support for increased alignment with public health goals. However, the study highlights that interventions need to move beyond individual officer training and address the broader structural and organizational setting in which police practices towards sex work operate.

Conclusions: A more in-depth understanding of the circumstances that drive law enforcement approaches to street-based sex work is critical to the collaborative design of interventions with police in different settings. In considering public health-police partnerships to address the needs of sex worker populations in the U.S. and elsewhere, this study supports existing calls for decriminalization of sex work, supported by institutional and policy reforms, neighborhood-level dialogues that shift the cultural landscape around sex work within both the police and larger community, and innovative individual-level police trainings.
Short or Long Antibiotic Regimes in Orthopaedics (SOLARIO): a Randomised Controlled Open-Label Non-Inferiority Trial of Duration of Systemic Antibiotics in Adults with Orthopaedic Infection Treated Operatively with Local Antibiotic Therapy
Authors: Dudareva Maria , Kümin Michelle , Vach Werner , Kaier Klaus , Ferguson Jamie , McNally Martin , Scarborough Matthew 
Published: September 2019

Abstract
Background Orthopaedic infections such as osteomyelitis, diabetic foot infection and prosthetic joint infection, are most commonly treated by a combination of surgical debridement and a prolonged course of systemic antibiotics, usually for at least 4 -6 weeks. Use of local antibiotics, implanted directly into the site of infection at the time of surgery, may improve antibiotic delivery and allow us to shorten the duration of systemic antibiotic therapy, thereby limiting the frequency of side effects, cost and selection pressure for antimicrobial resistance. Methods SOLARIO is a multi-centre open label randomised controlled non-inferiority trial comparing short and long systemic antibiotic therapy alongside local antibiotic therapy. Adult patients with orthopaedic infection, who have given informed consent, will be eligible to participate in the study provided that no micro-organisms identified from deep tissue samples are resistant to locally-implanted antibiotics. Participants will be randomised in a 1:1 ratio to receive either a short course (≤ 7 days) or currently recommended long course (≥ 4 weeks) of systemic antibiotics. The primary outcome will be treatment failure by 12 months following surgery, as ascertained by an independent Endpoint Committee blinded to treatment allocation. An absolute non-inferiority margin of 10% will be used for both per-protocol and intention-to-treat populations. Secondary outcomes will include probable and definite treatment failure, serious adverse events, treatment side-effects, quality of life scores and cost analysis. Discussion This study aims to assess a treatment strategy that may enable the reduction of systemic antibiotic use for patients with orthopaedic infection. If effective, this will be to the advantage of patients and contribute to antimicrobial stewardship.
Determinants of health-related quality of life among adolescents with cerebral palsy in Bangladesh
Authors: Power Rosalie , Galea Claire , Muhit Mohammad , Heanoy Eamin , Karim Tasneem , Badawi Nadia , Khandaker Gulam 
Published: September 2019

Abstract
Background: The health-related quality of life (HRQoL) of adolescents with cerebral palsy (CP) in low and middle-income countries is often poor, as is the case in Bangladesh. This study examined what modifiable factors are predictors of HRQoL among adolescents with CP in rural Bangladesh, a typical low- and middle-income country (LMIC).
Methods: Adolescents with CP (10 to 18y) were identified using the Bangladesh Cerebral Palsy Register. HRQoL was assessed with the Cerebral Palsy Quality of Life-Teens questionnaire (CPQoL-Teens). Bivariate analysis and hierarchical multiple linear regression models related adolescent clinical characteristics and mental health, caregiver mental health and proxies of socioeconomic status to HRQoL outcomes.
Results: 154 adolescents with CP (mean age 15y 1mo SD 1y 8mo, female n =31.2%) participated in this study. Numerous characteristics correlated to HRQoL; strongest correlation was between ‘feelings about functioning’ and motor impairment ( r =0.545). Nine factors were predictive of CPQoL-Teens dimensions; adolescent sex, school attendance, severity of motor impairment, hearing and speech impairment, mother’s education, primary caregiver depression and stress, and having a sanitary latrine at home resulting in score changes of between 0.79 (95% CI 0.24 to 1.35) to 35.1 (95% CI 6.03 to 64.22).
Conclusions: Many of the factors predicting the HRQoL of adolescents with CP are amenable to intervention, and have the potential to improve adolescent wellbeing. Several determinants are priorities of the sustainable development goals (SDGs); these findings should inform resource prioritization to improve the wellbeing of adolescents with CP in Bangladesh and other LMICs.
How does a targeted active labour market program impact on the well-being of the unemployed? A Concept Mapping study on Barcelona “Employment in the Neighbourhoods”
Authors: Puig-Barrachina Vanessa , Malmusi Davide , Artazcoz Lucía , Bartoll Xavier , Clotet Eva , Cortés-Franch Imma , Ventura Lorena , Daban Ferran , Díez Èlia , Borrell Carme 
Published: September 2019

Abstract
Background In 12 neighbourhoods of Barcelona (Spain), an innovative tailored-made Active Labour Market Program called “Employment in the neighbourhoods” was implemented to get people from deprived, high-unemployment neighbourhoods back to work. This study aimed to identify the effects of the program on participants’ quality of life, as well as the mechanisms underlying these effects. Methods We used Concept Mapping, a mixed methods approach that combines qualitative and quantitative analysis to develop a conceptual map of perceptions of participants and technical staff about changes in the participants’ quality of life. Data collection occurred within the generation and structuring steps where participants brainstorm answers to the focus question, and then rate and sort the responses. To compute maps, we used Concept Systems Incorporated software which conducted two main forms of analysis, a multidimensional scaling analysis followed by hierarchical cluster analysis. Results Study participants report several positive effects on mental health and emotional wellbeing, including self-esteem and empowerment. The mechanisms identified were strengthened social networks, skills acquisition and emotional and technical coaching. We also identified some negative impacts, mainly related to the labour market situation. We observed marked gender differences in the discourses of program participants. Conclusions The results obtained have allowed us to identify different mechanisms and impacts by which the “Employment in the Neighbourhoods” Active Labour Market Programme can influence the quality of life of participants from the most deprived areas of Barcelona. Improvement on mental health has been also shown in a pre-post evaluation using quantitative methodology