bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subjective Cognitive Decline Prediction of Mortality: Results from the Einstein Aging Study
Authors: Katz Mindy J. , Wang Cuiling , Derby Carol A. , Lipton Richard B. , Zimmerman Molly E. , Sliwinski Martin J. , Rabin Laura A. 
Published: September 2018

Background: The relation of pre-dementia stages to mortality has not been fully explored. Previous work examining subjective cognitive decline (SCD) and mortality is limited and mixed regarding methods used and consistency of findings. Objective: To examine SCD and mortality in a longitudinal, community-based cohort, using item response theory (IRT) methodology to form a composite SCD measure. Also, to assess whether this relationship was independent of clinical cognitive status. Methods: The Einstein Aging Study is a diverse longitudinal cohort of adults aged ≥70. SCD items were extracted from baseline CERAD questionnaires and a composite score was formed using IRT methodology. A total of 1,741 participants with complete data were clinically diagnosed as cognitively normal, or as having amnestic mild cognitive impairment (aMCI), nonamnestic mild cognitive impairment (naMCI), or dementia. 645 deaths occurred over a period of 8,912 person-years of follow-up. Cox proportional hazard models predicted time to death adjusting for covariates. Results: A one standard deviation unit increase in level of SCD was associated with >20% higher risk of mortality. However, when models were adjusted for clinical cognitive status, the association was no longer significant. Both dementia and aMCI predicted mortality. Furthermore, when analyses focused only on those without cognitive impairment, SCD level did not predict mortality. Conclusions: The association of SCD with mortality may be due to the association of SCD with clinical cognitive status. Thus, SCD may be used as a community-based screen to initially identify those with cognitive impairment who may be at greatest risk for death.
Amyloid and FDG PET of Successful Cognitive Aging: Global and Cingulate-Specific Differences
Authors: Baran Timothy M. , Lin Feng Vankee ,   Alzheimer’s Disease Neuroimaging Initiative
Published: September 2018

Background: Some individuals, called Supernormals (SN), maintain excellent memory in old age. While brain structural and functional integrity in SN seem to be aging-resistant, their amyloidosis and neural injury status has not been well studied. Objective: The goal of this study was to compare cortical amyloid deposition and glucose metabolism between SN and older adults with normal cognition (NC), amnestic mild cognitive impairment (MCI), and Alzheimer’s disease (AD). Methods: Subjects from the ADNI database were included if they received T1-weighted MRI, amyloid PET, FDG-PET, and cognitive testing within a 6-month period, yielding 27 AD, 69 MCI, 172 NC, and 122 SN. PET standardized uptake value ratios (SUVrs) were calculated for the whole cortex and 68 regions of interest, with whole cerebellum serving as reference. Results: SN had lower whole cortex amyloid than MCI, and higher glucose metabolism than all others. Regional analysis revealed that amyloid burden and glucose metabolism in the right isthmus cingulate cortex differed in SN compared to others, while SN glucose metabolism also differed from others in several frontal and temporal regions. Conclusion: Preserved cortical glucose metabolism, and lower levels of amyloidosis and glucose hypometabolism in the right isthmus cingulate cortex, contributes to the Supernormal phenomenon. These findings may be informative for development of early screening biomarkers and therapeutic targets for modification of cognitive trajectories.
Effects of chitosan oligosaccharides postharvest treatment on the quality and ripening related gene expression of cultivated strawberry fruits
Authors: He Yanqiu , Bose Santosh Kumar , Wang Mengyu , Liu Tongmei , Wang Wenxia , Lu Hang , Yin Heng 
Published: September 2018

BACKGROUND: Chitosan oligosaccharide (COS), degraded from chitosan, has been proved as an effective plant immunity elicitor, eco-friendly, easily soluble in water and influenced several secondary metabolites content to improve fruit qualities. OBJECTIVE: The effects of chitosan oligosaccharides (COS) on the quality and ripening related gene expression of strawberry ( Fragaria× ananassa cv . qingxiang) during storage were investigated in this study. METHODS: COS was dissolved in distilled water at a concentration of 50 and 100 mg·L–1. Then the fruits were dipped in COS solution and the control group was dipped in equal amount of distilled water for 1 minute. After that the fruits were air-dried and stored at 20±0.5°C with 80±2% relative humidity. RESULTS: COS treated fruits significantly delayed the loss of hardness, total sugar and ascorbate content. In addition, COS treatments had positive effect on maintaining higher concentration of total phenol, anthocyanin content and antioxidant activity. Moreover, COS treatments also had positive effect on inhibition of relative gene expression of cell wall polysaccharides degradation pathways, including pectate lyase ( FaPL), pectin esterase ( FaPE) and endoglucanase ( FaEG) and ethylene biosynthesis ( FaACS and FaACO) pathway. These findings suggest that the use of COS 100 mg·L–1 postharvest treatment is useful for maintaining quality and storage life of strawberry fruits. CONCLUSION: COS postharvest treatment appeared to have a beneficial impact on the quality retention, maintained lower activities of cell wall degradation and the ethylene biosynthesis pathway by suppressing the gene expression during storage of strawberry.
Risiko terjadinya rinitis akibat kerja pada pekerja yang terpajan debu terigu
Authors: Quadarusman Emanuel , Rahardjo Sutji Pratiwi , Punagi Abdul Qadar , Djamin Riskiana 
Published: September 2018

Background: Occupational rhinitis (OR) may decrease quality of life and productivity, but there is still little information about occupational rhinitis in flour industries. Purpose: To know the influence of atopic history, working duration, work placement and face-mask use in the incidence of occupational rhinitis in wheat flour workers of PT. X in Makassar. Methods: A cross-sectional study on workers in production and packing sections of flour factory X had been conducted. Result: Prevalence of occupational rhinitis in that factory was about 50.7%, and there was a significant relationship between atopic history and work placement with OR incidence (p<0.05). Conclusion: There was a significant relationship between atopic history and work placement with OR incidence, but relationship between OR with working duration and face-mask use could not be established. It was shown that in atopic workers, longer working duration and un-routine use of face-mask increased the risk of OR incidence twice higher. Keywords: occupational rhinitis, flour dust, face mask Abstrak : Latar belakang: Rinitis akibat kerja (RAK) dapat mempengaruhi kualitas hidup pekerja, menghilangkan banyak waktu kerja dan dapat menurunkan produktivitas, namun masih sedikit informasi yang dimiliki mengenai epidemiologi pada industri terigu. Tujuan: Untuk mengetahui pengaruh riwayat atopi, lama bekerja, bagian kerja dan penggunaan masker terhadap kejadian rinitis akibat kerja pada pekerja pabrik terigu X di Makassar. Metode: Suatu studi potong lintang pada pekerja bagian produksi dan pengepakan di pabrik terigu X. Hasil: Didapatkan angka kejadian RAK pada pekerja pabrik adalah 50,7%, dan terdapat hubungan yang bermakna antara atopi dan tempat kerja dengan kejadian RAK (p<0,05). Kesimpulan: Faktor atopi dan tempat kerja dapat mempengaruhi angka kejadian RAK, sedangkan hubungan antara RAK dengan lama kerja dan penggunaan masker belum dapat dibuktikan. Didapati bahwa pada pekerja dengan riwayat penyakit atopi semakin lama masa kerja dan dengan penggunaan masker tidak rutin dapat meningkatkan risiko dua kali lebih tinggi untuk terkena RAK. Kata kunci: rinitis akibat kerja, debu terigu, masker
Pengaruh suplementasi probiotik Lactobacillus casei L shirota strain terhadap kadar IgE penderita rinitis alergi
Authors: Widuri Asti , Suryani Lilis 
Published: September 2018

Background: Allergic rhinitis is a nasal mucosal inflammatory reactions mediated by immunoglobulin E (IgE), after allergen exposure. Probiotics is considered has strong influence on the regulation of primary immunophysiology in intestinal mucosal barrier and might be useful to prevent allergy attacks.Purpose: To study the benefits of Lactobacillus casei Shirota strain L in preventing allergy attacks through the mechanism of immunomodulatory systems that inhibit the production of IgE. Methods:The study was quasi-experimental with pretest-posttest design. The subjects were 45 students with history of allergic rhinitis. Serum IgE levels were measured before and after given milk containing probiotics for one month. Results: With a paired t test, there was significant difference of the average IgE levels between before (291.88 IU/L) and after one month. Probiotic supplementation (141.43 IU/L),p<0.05. Conclusion: Supplementation of probiotic Lactobacillus casei Shirota strain L is useful in preventing allergy attacks. Keywords: allergic rhinitis, probiotics, immunoglobulin E (IgE) Abstrak : Latar belakang: Rinitis alergi adalah reaksi peradangan mukosa hidung yang diperantarai oleh imunoglobulin E (IgE) setelah terjadi pajanan alergen. Pemberian probiotik dianggap mempunyai pengaruh yang kuat terhadap regulasi imunofisiologi primer dalam barier mukosa usus. Tujuan:Mengkaji manfaat suplemen probiotik Lactobacillus casei L shirota strain dalam mencegah serangan alergi melalui mekanisme sistem imunomodulator yang menghambat produksi IgE. Metode: Desain penelitian adalah eksperimental kuasi case control dengan rancangan pretest-postest design. Subjek penelitian adalah 45 orang yang mempunyai riwayat rinitis alergi, diambil darah sampel untuk diperiksa kadar IgE sebelum dan setelah diberi susu yang mengandung probiotik selama satu bulan. Hasil: Dengan paired t test, terdapat perbedaan bermakna antara rata-rata kadar IgE sebelum suplementasi (291,88 IU/L) dan setelah diberi suplementasi probiotik Lactobacillus casei Lshirota strain selama satu bulan (141,43 IU/L), p<0,05. Kesimpulan: Suplementasi probiotikLactobacillus casei L shirota strain bermanfaat dalam mencegah serangan alergi melalui mekanisme imunomodulator yang menghambat produksi IgE. Kata kunci: rinitis alergi, probiotik, imunogobulin E (IgE)
Validitas metode rinohigrometri sebagai indikator sumbatan hidung
Authors: Djalal Rachmawati , Punagi Abdul Qadar , Sulaiman Andi Baso , Perkasa Fadjar 
Published: September 2018

Background: The narrowing of nasal cavity due to nasal mucosa changes or other factors may leadsto nasal obstruction. Symptoms of nasal obstruction can be classified from mild to severe and in somecases total obstruction may occur. Purpose: The objective of the research was to determine the validity of rhinohygrometric method as nasal obstruction indicator. The complaint of nasal obstruction depicted theexistence of abnormalities either anatomically, physiologically or pathologically. The evaluation of thenasal obstruction was based on anamnesis, physical examination and also supporting examination forthe measurement of the nasal patency. Method: An analytic study had been carried out on the diagnostic test for determining sensitivity and specificity values of rhinohygrometeric method as nasal obstruction indicator compared with peak nasal inspiratory flow (PNIF) as the basic standard on subjects who hadnasal obstruction and subjects who did not have nasal obstruction. Results: In the research, the valuesof cutting off point rhinohygrometeric method are 3 cm and 4 cm on the length and width, while thevalue of basic standard of PNIF cutting off point is 80 liter/minute. Sensitivity and specificity methodof rhinohygrometeric on the length were 87.8% and 100% while on the width were 95.1% and 89.8%.Conclusion: Rhinohigrometeric method has validity as indicator of nasal obstruction. Keywords: rhinohygrometeric method, nasal obstruction, cutting off point, sensitivity and specificity Abstrak : Latar belakang: Setiap penyempitan rongga hidung baik akibat proses perubahan pada mukosahidung ataupun penyebab yang lain akan mengakibatkan timbulnya gejala sumbatan hidung. Gejalasumbatan hidung dapat bersifat ringan sampai berat bahkan dapat terjadi sumbatan total. Tujuan: Untukmenentukan validitas metode rinohigrometri sebagai indikator sumbatan hidung. Metode: Penelitian inimenggunakan studi analitik terhadap uji diagnostik untuk menentukan nilai sensitivitas dan spesifisitasmetode rinohigrometri sebagai indikator sumbatan hidung dibandingkan dengan peak nasal inspiratoryflow (PNIF) sebagai standar baku pada subjek yang mengalami sumbatan hidung dan subjek yang tidakmengalami sumbatan hidung. Hasil: Penelitian menunjukkan bahwa telah ditetapkan nilai titik potongmetode rinohigrometri adalah 3 cm dan 4 cm pada sisi panjang dan lebar, sedangkan nilai titik potongstandar baku PNIF adalah 80 liter/menit. Sensitivitas dan spesifisitas metode rinohigrometri padasisi panjang adalah 87,8% dan 100%, sedangkan pada sisi lebar adalah 95,1% dan 89,8%. Kesimpulan:Metode rinohigrometri memiliki validitas sebagai indikator sumbatan hidung. Kata kunci: metode rinohigrometri, sumbatan hidung, titik potong, sensitivitas, spesifisitas
Analisis pedigree gangguan pendengaran dan ketulian pada penduduk dusun Sepang, Polewali Mandar, Sulawesi Barat
Authors: Perkasa Muhammad Fadjar , Punagi Abdul Qadar , K Khaeruddin 
Published: September 2018

Background. Pedigree Analysis of hearing loss and deafness in the population of Sepang hamlet, Tenggelang village, Luyo district, Polewali Mandar regency, West Sulawesi. Purpose: To determine the inheritance pattern of hearing loss and deafness in the population of Sepang Hamlet. Methods: Explorative study was conducted among 167 people using pure tone audiometry Interacoustics AD229 type, impedance audiometry Madsen Electronics Zodiac type 901 and Otoread Interacoustics TEOAE. Pedigree of the subjects were made and analyzed. Results: The result of Chi-square goodness of fit showed that the test of conformity with the notion of inheritance pattern of hearing loss and deafness were autosomal dominant, obtain the results of χ²= 6.721>χ² = 3.84 and p value =0,01<0,05, with df = 1, while assuming conformance testing inheritance pattern of hearing loss and deafness were autosomal recessive, obtain the results of χ ² =0,628 < χ²tabeltabel=3.84 and p value= 0.428>0.05 with df = 1. Conclusion: The inheritancepattern of hearing loss and deafness in familial marriage in the population of Sepang hamlet, Tenggelang village, Luyo district, Polewali Mandar regency, West Sulawesi was found to be autosomal recessive transmission. Keywords: pedigree analysis, familal marriage, hearing loss, deafness, Polewali Mandar, West Sulawesi. Abstrak : Latar Belakang: Gangguan pendengaran dan ketulian ditemukan pada penduduk Dusun Sepang, Desa Tenggelang, Kecamatan Luyo, Kabupaten Polewali Mandar Sulawesi Barat yang mempunyai adat perkawinan keluarga. Tujuan: Analisis pedigree ini bertujuan menentukan pola pewarisan gangguan pendengaran dan ketulian pada penduduk dusun tersebut. Metode: Jenis penelitian ini adalah studi eksploratif dengan jumlah subjek sebanyak 167 orang. Pemeriksaan yang dilakukan adalah audiometri nada murni menggunakan audiometer merk Interacoustics tipe AD229, Audiometer impedans merk Madsen Electronics tipe Zodiac 901 dan TEOAE merk Interacoustics tipe Otoread. Subjek dibuatkan pedigree dan dianalisis. Hasil: Uji statistik chi-square test goodness of fit menunjukkan bahwa uji kesesuaian dengan anggapan pola pewarisan gangguan pendengaran dan ketulian secara autosomal dominan didapatkan nilai χ² hasil=6,721 > χ² = 3,84 dan nilai p= 0,01<0,05 dengan df = 1, sedangkan uji kesesuaian dengan anggapan pola pewarisan gangguan pendengaran dan ketulian secara autosomal resesif didapatkan nilai χ² hasil=0,628 <χ²tabeltabel =3,84 dan nilai p=0,428>0,05 dengan df =1. Kesimpulan: Pola pewarisan gangguan pendengaran dan ketulian pada perkawinan keluarga pada penduduk dusun Sepang, Desa Tenggelang, Kecamatan Luyo, Kabupaten polewali Mandar Sulawesi Barat terjadi melalui transmisi autosomal resesif. Kata Kunci : analisis pedigree, perkawinan keluarga, gangguan pendengaran, ketulian, Polewali Mandar, Sulawesi Barat
Ekstraksi benda asing gigi palsu di esofagus dengan esofagotomi servikal
Authors: Cahyono Arie , Hermani Bambang , Hadjat Fachri , Rahman Sukri 
Published: September 2018

Background: Foreign body in the esophagus should be removed as soon as possible under optimal conditions to prevent complications. Esophagoscopy is a safe and effective procedure for foreign bodies removal in most cases, but in some cases esophagoscopy could not be performed or failed to extract the foreign body, necessitating surgery such as esophagotomy. Objective: To illustrate the cervical esophagotomy technique as a management of esophageal foreign bodies. Case: A 53-years old woman with a foreign body (dentures) in the esophagus that failed to be removed by esophagoscopy and need cervical esophagotomy. Management: Cervical esophagotomy was performed after esophagoscopy failed to remove the foreign body. Conclusion: Cervical esophagotomy is needed in cases of esophageal foreign body in which of esophagoscopy could not be performed or failed to remove the foreign body. Keywords : foreign body, denture, esophagus, cervical esophagotomy Abstrak : Latar Belakang: Benda asing di esofagus harus sesegera mungkin dikeluarkan dalam kondisi yang optimal untuk mencegah terjadinya komplikasi. Esofagoskopi adalah cara yang aman dan efektif untuk ekstraksi benda asing pada sebagian besar kasus, namun pada beberapa kasus tindakan esofagoskopi tidak dapat dilakukan atau gagal mengeluarkan benda asing, sehingga diperlukan tindakan bedah berupa esofagotomi. Tujuan: Kasus ini diajukan untuk mengilustrasikan teknik esofagotomi servikal sebagai penatalaksanaan benda asing esofagus. Kasus: Dilaporkan satu kasus wanita 53 tahun dengan benda asing gigi palsu di esofagus yang gagal dikeluarkan dengan esofagoskopi sehingga diperlukan tindakan esofagotomi servikal untuk mengambilnya. Penatalaksanaan: Dilakukan esofagotomi servikal setelah esofagoskopi gagal mengeluarkan benda asing. Kesimpulan: Esofagotomi servikal dilakukan untuk mengeluarkan benda asing di esofagus apabila tindakan esofagoskopi tidak dapat dilakukan atau gagal mengeluarkan benda asing. Kata kunci : benda asing, gigi palsu, esofagus, esofagotomi servikal.
Validitas pemeriksaan rapid test immunochromatography berbasis EBV pada penderita karsinoma nasofaring di Makassar
Authors: Nazaruddin Helen , Savitri Eka , Akil Muhammad Amsyar , Carolina Jane 
Published: September 2018

Background: Nasopharyngeal carcinoma (NPC) is a malignant tumor that grows in the nasopharynx with a predilection for the Rosenmuller fossa and the roof of the nasopharynx. NPC shows unspecific early symptoms and is often diagnosed at advanced stages, with treatment success rate lower than if treated at earlier stages. Purpose: To assess the sensitivity of NPC test strip against ELISA in the detection of nasopharyngeal carcinoma and to assess the specificity of NPC test strip against ELISA in the detection of nasopharyngeal carcinoma. Methods: A diagnostic study of 66 samples, consisting of 38 NPC patients and 28 relatives of NPC patients. Each blood sample was taken for Elisa and NPC tests strip. Data were analyzed using cross tabulation. Results: NPC test strip showed sensitivity 78% compared to ELISA in the detection of nasopharyngeal carcinoma with addition 75% false positives and positive predictive value of 76,47%. NPC test strip specificity was 25% compared to ELISA in detecting nasopharyngeal carcinoma, with false negative 22% and negative predictive value of 26.67%. Conclusion: The use of NPC test strip in early detection of NPC could not be recommended, given the low sensitivity and specificity NPC Test Strip in this study. Keywords: Nasopharyngeal carcinoma, ELISA, NPC Test Strip Abstrak : Latar belakang: Karsinoma nasofaring (KNF) adalah tumor ganas yang tumbuh di daerah nasofaring dengan predileksi di fossa Rosenmuller dan atap nasofaring. KNF menunjukkan beberapa gejala awal yang tidak spesifik sehingga seringkali terdiagnosis pada stadium lanjut, dengan angka keberhasilan pengobatan yang lebih rendah dibandingkan jika diobati pada stadium awal. Tujuan: Menilai sensitifitas NPC test strip dibandingkan terhadap ELISA dalam mendeteksi karsinoma nasofaring dan menilai spesifitas NPC test strip dibandingkan terhadap ELISA dalam mendeteksi karsinoma nasofaring. Metode: Penelitian ini merupakan uji diagnostik dengan jumlah sampel sebesar 66 yang terbagi atas 38 pasien KNF dan 28 adalah keluarga dari pasien KNF. Masing-masing sampel diambil darahnya untuk kemudian dilakukan pemeriksaan ELISA dan NPC test strip. Data dianalisis menggunakan tabulasi silang. Hasil: Sensitifitas NPC test strip dibandingkan terhadap ELISA dalam mendeteksi karsinoma nasofaring adalah sebesar 78%, dengan positif palsu sebesar 75% dan nilai prediksi positif sebesar 76,47%. Spesifitas NPC test strip dibandingkan terhadap ELISA dalam mendeteksi karsinoma nasofaring adalah sebesar 25%, dengan negatif palsu sebesar 22% dan nilai prediksi negatif sebesar 26,67%. Kesimpulan: Penggunaan NPC test strip dalam deteksi dini KNF belum dapat direkomendasikan mengingat masih rendahnya sensitifitas dan spesifitas NPC test strip ini. Kata Kunci: Karsinoma nasofaring, ELISA, NPC test strip.