bluuebunny/crossref_metadata_2025_split huggingface dataset:
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus
Authors: Dalan Rinkoo , Liuh Ling Goh 
Published: May 2018

Introduction and background Haptoglobin (Hp) is considered to be an antioxidant and protective against cardiovascular complications. Polymorphisms in the Hp gene interact with diabetes mellitus to affect the risk of vascular complications. Methods We review the updated literature about the protean role of Hp and Hp genotypes spanning genomics, molecular, translational and clinical studies. We searched Pubmed, SCOPUS and Google Scholar for all articles using the keywords: haptoglobin and/or haptoglobin polymorphism and diabetes. We review the diverse Hp genotypes, phenotypes and the impact on diabetes complications, including lessons from animal models and in vitro models. We describe the clinical studies on the associations of Hp genotypes with vascular complications in type 1 and type 2 diabetes comprehensively. We review the studies looking at vitamin E supplementation in a personalized manner in Hp2-2 diabetes individuals. Results and conclusion Hp genotypes have evolved as a result of deletions in the traditional Hp genes. The Hp genotypes have been associated with microvascular and macrovascular complications in type 1 diabetes mellitus but the association in type 2 diabetes is more consistent with cardiovascular complications. A preferential benefit of vitamin E and other antioxidants in the Hp2-2 genotype for cardiovascular complications in type 2 diabetes has been seen presumably secondary to interaction with high-density lipoprotein function. Hence, the Hp genotype can be used to personalize antioxidant therapeutics in diabetes patients. These results need to be corroborated in large, global, pragmatic, prospective, cardiovascular outcome trials in type 2 diabetes patients.
Efficacy of nature-based therapy for individuals with stress-related illnesses: randomised controlled trial
Authors: Stigsdotter Ulrika Karlsson , Corazon Sus Sola , Sidenius Ulrik , Nyed Patrik Karlsson , Larsen Helmer Bøving , Fjorback Lone Overby 
Published: May 2018

BackgroundStress-related illnesses are a major threat to public health, and there is increasing demand for validated treatments.AimsTo test the efficacy of nature-based therapy (NBT) for patients with stress-related illnesses.MethodRandomised controlled trial (ClinicalTrials.gov ID NCT01849718) comparing Nacadia® NBT (NNBT) with the cognitive–behavioural therapy known as Specialised Treatment for Severe Bodily Distress Syndromes (STreSS). In total, 84 participants were randomly allocated to one of the two treatments. The primary outcome measure was the mean aggregate score on the Psychological General Well-Being Index (PGWBI).ResultsBoth treatments resulted in a significant increase in the PGWBI (primary outcome) and a decrease in burnout (the Shirom–Melamed Burnout Questionnaire, secondary outcome), which were both sustained 12 months later. No significant difference in efficacy was found between NNBT and STreSS for primary outcome and secondary outcomes.ConclusionsThe study showed no statistical evidence of a difference between NNBT and STreSS for treating patients with stress-related illnesses.Declaration of interestNone.
The Cash Flow Advantages of 3PLs as Supply Chain Orchestrators
Authors: Chen Xiangfeng , Cai Gangshu (George) , Song Jing-Sheng 
Published: May 2018

With an increasingly open global economy and advanced technologies, some third-party logistics providers (3PLs), such as Eternal Asia, have emerged as supply chain orchestrators, linking buyers with manufacturers worldwide. In addition to their traditional transportation services, these orchestrators provide procurement and financial assistance to buyers in the supply network, especially small- and medium-sized enterprises (SMEs) in developing countries. Oftentimes, the 3PLs can obtain payment delay arrangements from the financially stronger manufacturers, which in turn can be partially extended to the SME buyers, alleviating their high costs of capital. To illustrate the efficiency improvements of the aforementioned practice, we use a model to explicitly capture the cash-flow dynamics in a supply chain consisting of a manufacturer, a buyer, and a 3PL firm and explore the conditions under which this innovation benefits all parties in the supply chain so that the business model is sustainable. We characterize these conditions and show that the supply chain profit can be higher under leadership by the 3PL than by the manufacturer. The intermediary role of the 3PL is crucial, in that its benefit may vanish if the manufacturer chooses to directly grant payment delay to the buyers. We demonstrate that the benefit is more likely to occur with more buyers. We further identify the unique Nash bargaining solution for the transportation time and the payment delay grace period. The online appendix is available at https://doi.org/10.1287/msom.2017.0667 . This paper has been accepted for the Manufacturing & Service Operations Management Special Issue on Value Chain Innovations in Developing Economies.
A community based approach to reduce the incidence of preventable pressure ulcers
Authors: Haran Emma 
Published: May 2018

The prevention of pressure ulcers in the community is a major challenge for healthcare organisations. Pressure ulcers cost the NHS millions of pounds in treatment and prevention strategies. Everyone involved in the care of individuals at risk of developing pressure ulcers has a role to play in their prevention. Community specialist practitioners are in an ideal position to provide education and skills to healthcare workers in community settings. They are experts in their field so are valuable within the community setting.
Positive impact of bio-stimulators on growth and physiological activity of willow in climate change conditions
Authors: Piotrowski Krzysztof , Romanowska-Duda Zdzisława 
Published: May 2018

Abstract
The aim of this research was to evaluate the physiological activity and growth of willow (Salix viminalis L.) plants cultivated under the conditions of adverse temperature and soil moisture content, and to assess the effect of the foliar application of Biojodis (1.0%) and Asahi SL (0.03%) bio-stimulators, or a mixture of Microcistis aeruginosa MKR 0105 and Anabaena PCC 7120 cyanobacteria under such changing growth conditions. The obtained results showed different reactions to the applied constant or periodically changed temperature and soil moisture content. The plants which grew at periodically changed adverse temperature (from -5 to 40oC) or in scantily (20% m.c.) or excessively (60% m.c.) watered soils, grew slowly, in comparison with those growing at 20oC and in optimally moistened soil (30% m.c.). Foliar application of Biojodis and Asahi SL cyanobacteria increased the growth of willow at optimal and adverse temperature or in scantily and excessively moistened soil. The changes in plant growth were associated with the changes in electrolyte leakage, activity of acid or alkaline phosphatases, RNase, index of chlorophyll content in leaves and gas exchange. The above indicates that the foliar application of the studied cyanobacteria and bio-stimulators partly alleviates the harmful impact of adverse temperature and water stress on growth and physiological activity of willow plants
IgG4-related sclerosing cholangitis mimicking hilar cholangiocarcinoma (Klatskin tumor): a case report of a challenging disease and review of the literature
Authors: Mittelstaedt Anke , Meier Peter N. , Dankoweit-Timpe Eva , Christ Beate , Jaehne Joachim 
Published: May 2018

AbstractBackground:Even though IgG4-related disease has gained increased attention worldwide, the diagnosis remains challenging. IgG4-related sclerosing cholangitis (IgG4-SC) is not well described in the western hemisphere and may mimic cholangiocarcinoma (CC), especially when occurring without other symptoms such as, e.g. concurrent pancreatitis or retroperitoneal fibrosis. We present a case to add further information to the diagnosis and treatment of this challenging disease.Case report:A 60-year-old male patient presented with painless jaundice. Prior medical history showed diabetes mellitus type I, high blood pressure, and deep vein thrombosis. Diagnostic investigations were strongly suspicious of a Klatskin tumor, although biopsies were inconclusive. The tumor marker Carbohydrate Antigen 19-9 (CA 19-9) was elevated. Prior to the recommended surgery, the patient had two second opinions in two different university hospitals, both arguing for surgery as well. The patient received hilar resection with right hemihepatectomy. During the postoperative course, some major complications occurred, i.e. recurrent pleural effusion, abscess in the liver resection area, sepsis, ileus, and restricted liver metabolism. Treatment with prednisolone did not show any improvement. Approximately 3 months after surgery, the patient died in consequence of acute respiratory failure. Histology showed no signs of CC, but IgG4-SC could be diagnosed.Conclusion:In the case of preoperative signs of CC, differential diagnosis of IgG4-SC needs to be considered, in particular, in cases with missing histologic proof of malignant disease.
Tissue engineering in pediatric urology – a critical appraisal
Authors: Schäfer Frank-Mattias , Stehr Maximilian 
Published: May 2018

AbstractTissue engineering is defined as the combination of biomaterials and bioengineering principles together with cell transplantation or directed growth of host cells to develop a biological replacement tissue or organ that can be a substitute for normal tissue both in structure and function. Despite early promising preclinical studies, clinical translation of tissue engineering in pediatric urology into humans has been unsuccessful both for cell-seeded and acellular scaffolds. This can be ascribed to various factors, including the use of only non-diseased models that inaccurately describe the structural and functional modifications of diseased tissue. The paper addresses potential future strategies to overcome the limitations experienced in clinical applications so far. This includes the use of stem cells of various origins (mesenchymal stem cells, hematopoietic stem/progenitor cells, urine-derived stem cells, and progenitor cells of the urothelium) as well as the need for a deeper understanding of signaling pathways and directing tissue ingrowth and differentiation through the concept of dynamic reciprocity. The development of smart scaffolds that release trophic factors in a set and timely manner will probably improve regeneration. Modulation of innate immune response as a major contributor to tissue regeneration outcome is also addressed. It is unlikely that only one of these strategies alone will lead to clinically applicable tissue engineering strategies in pediatric urology. In the meanwhile, the fundamental new insights into regenerative processes already obtained in the attempts of tissue engineering of the lower urogenital tract remain our greatest gain.
Physical Fitness Predictors of a Warrior Task Simulation Test
Authors: Huang Hung-Chun , Nagai Takashi , Lovalekar Mita , Connaboy Christopher , Nindl Bradley C. 
Published: May 2018

Abstract
Huang, H-C, Nagai, T, Lovalekar, M, Connaboy, C, and Nindl, BC. Physical fitness predictors of a warrior task simulation test. J Strength Cond Res 32(9): 2562–2568, 2018—The warrior task simulation test (WTST) has been developed in an attempt to better assess physical fitness required for soldiers to perform battlefield tasks and drills to determine whether laboratory-based measurements of physical fitness components could be used to predict the WTST. Forty-three healthy and physically active men participated in 2 sessions: the WTST and laboratory testing. The WTST comprised 282-m run, low hurdles, high crawl, casualty drag, balance beam, point-aim-move, 100-yard sprint, and agility sprint with participants wearing combat boots, uniform, helmet, and dummy rifle. The laboratory testing included assessments of participants' muscular strength and endurance, postural stability, aerobic capacity, anaerobic capacity, flexibility, body fat, fat-free mass, and agility. Correlation and simple and multiple linear regression analyses were used to analyze the relationship between the WTST and laboratory testing and predict the WTST, respectively (p < 0.05). The correlation and the simple linear regression analyses revealed that anaerobic capability, aerobic capacity, body fat, agility, and muscular endurance correlated with (r = 0.35–0.59) and accounted for 12–34% of the variance in (R
2 = 0.12–0.34) the WTST performance (p < 0.05). The final model included aerobic capacity, agility, fat-free mass, muscular endurance, and body fat (R
2 = 0.52, p < 0.001). The current results highlighted the importance of several components of physical fitness in simulated battlefield tasks and drills (assessed by the WTST). In particular, anaerobic capacity, aerobic capacity, and body fat had the highest correlational and predictive values of the WTST. Additionally, skill-related components of physical fitness, such as agility and muscular endurance, should not be ignored, and they should be assessed and tracked with the above-mentioned components.
Shear Strength of Unsaturated Malaysian Granitic Residual Soil
Authors: Saffari Pooya , Noor Mohd Jamaludin Md. , Ashaari Yasmin , Asadi Afshin 
Published: May 2018

Abstract
This study aims to understand the shear strength of unsaturated Malaysian granitic residual soil. The soil was obtained from Kuala Klawang, Negeri Sembilan, Malaysia. A pressure plate was used for obtaining soil-water characteristic curves under zero net confining pressure. Multistage consolidated drained triaxial tests were carried out on both saturated and unsaturated compacted specimens at a constant strain rate. The experimental data of the saturated and unsaturated shear strength of the soil were fitted with a comprehensive constitutive shear strength model that represents both linear and nonlinear shear strength behaviors, with respect to suction and net stress or effective stress for unsaturated and saturated conditions, respectively.
An Experimental Study of Residual Stress Induced Modulation of Vibration Characteristics in 1-D MEMS Resonators
Authors: Behera A. R. , Dangi A. , Pratap R. 
Published: May 2018

Abstract
We experimentally study test structures of more than 100 microelectromechanical systems (MEMS) beam resonators with clamped ends and residual stresses varying from highly tensile to compressive loads beyond buckling and provide experimental verification of some key theoretical results reported in the literature. We compare the theoretically predicted natural frequencies over a large range of residual stresses that make the one-dimensional micro-mechanical resonators behave like beams or strings, depending on the relative magnitude of the effective axial load and the flexural stiffness. In particular, we measure the natural frequencies of the first four modes of buckled beams to show the drastically different behavior of beams under post critical buckling load from those under tension and, for the first time, present experimental evidence of invariance of even modes to compressive residual stresses in microscale beams. We then derive the sensitivity of these modes to residual stresses and discuss the consequences of such sensitivity on sensing applications along with recommendations on how to engineer the required level of residual stresses.
Echocardiography with Elevated Central Venous Pressure Diagnosing Constrictive Pericarditis More Accurately Than Chest CT Scan: A Retrospective Study in 36 Cases
Authors: Bao Liwen , Huang Jiechun , Wang Fangrui , Pang Liewen , Wang Yiqing , Shi Haiming 
Published: May 2018

Background: Constrictive pericarditis (CP) is defined as impaired diastolic cardiac function caused by a calcified and thickened pericardium. We assessed the clinical characteristics and time to diagnosis, as well as patient prognosis after pericardiectomy. Methods: We analyzed the records of 36 CP patients who underwent pericardiectomy at Huashan Hospital, China, between 2012 and 2015. Clinical manifestations, length of time to diagnosis, laboratory parameters, and diagnostic imaging results were examined. All patients underwent pericardiectomy, and were assessed post-operatively for quality of life and improvement of cardiac function using the Minnesota Living with Heart Failure Questionnaire (MLHFQ). Results: All patients displayed shortness of breath and polyserous effusion, as well as elevated pro B-type natriuretic peptide and thickened pericardium. Mean time between onset of symptoms and a definitive diagnosis of CP was 9.5 ± 2.1 months. Pericardiectomy was performed within one week of diagnosis. Mean central venous pressure decreased from a pre-operative 19.92 ± 6.6 mmHg to a post-operative 8.5 ± 2.7 mmHg. Within 1.5 ± 0.7 years of surgery, all patients maintained good quality of life and cardiac function, which resulted in a mean score of 0.9 ± 0.6 on the MLHFQ. Conclusion: A definitive diagnosis of CP is usually made long after the onset of symptoms. Early detection and diagnosis by echocardiography with elevated central venous pressure and early treatment by surgery are key to an improved prognosis and resumption of good cardiac function.
Myocarditis Associated with Immune Checkpoint Inhibitors: An Expert Consensus on Data Gaps and a Call to Action
Authors: Neilan Tomas G. , Rothenberg Mace L. , Amiri-Kordestani Laleh , Sullivan Ryan J. , Steingart Richard M. , Gregory William , Hariharan Subramanian , Hammad Tarek A. , Lindenfeld JoAnn , Murphy Martin J. , Moslehi Javid J. ,   on behalf of the Checkpoint Inhibitor Safety Working Group
Published: May 2018

Abstract
Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape for cancer. Due to the mechanism of action of ICIs, inflammatory reactions against normal tissue were an anticipated side effect of these agents; these immune-related adverse events have been documented and are typically low grade and manageable. Myocarditis has emerged as an uncommon but potentially life-threatening adverse reaction in patients treated with ICIs. Assessment and characterization of ICI-associated myocarditis is challenging because of its low incidence and protean manifestations. Nevertheless, the seriousness of ICI-associated myocarditis justifies a coordinated effort to increase awareness of this syndrome, identify patients who may be at risk, and enable early diagnosis and appropriate treatment. The “Checkpoint Inhibitor Safety Working Group,” a multidisciplinary committee of academic, industry, and regulatory partners, convened at a workshop hosted by Project Data Sphere, LLC, on December 15, 2017. This meeting aimed to evaluate the current information on ICI-associated myocarditis, determine methods to collect and share data on this adverse reaction, and establish task forces to close the identified knowledge gaps. In this report, we summarize the workshop findings and proposed steps to address the impact of ICI-associated myocarditis in patients with cancer.
Fiziksel Buhar Biriktirme Yöntemlerinden PVD ve JVD/DVD İnce Film Kaplamaların Karşılaştırılması ve DVD Kaplama Teknolojisinin Endüstriyel Uygulamaları Üzerine Kavramsal, Akademik ve Teorik Bir Analiz
Authors: AYTAÇ Ayhan , MALAYOĞLU Uğur 
Published: May 2018

Öz&nbsp;Günümüzde ülkelerin etkili ve güçlü silahlara sahip olması savunma
sanayindeki teknolojik gelişmeler ile ilişkilendirilmektedir. Bir ülkenin
ulusal teknolojisi, öncelikle savunma sanayindeki gelişmişlikle ölçülmektedir.
Endüstride, sürtünmeye maruz kalan, bu nedenle çalışmayan ve verimliliğini
kaybeden sistemlerin iyileştirilmesi amacıyla PVD, CVD, JVD/DVD, Plazma ve
Termal püskürtme teknikleri kullanılarak çeşitli kaplamaların yapıldığı görülmektedir.Bu
çalışmanın amacı, yüzey mühendisliği uygulamalarında sıklıkla kullanılan
fiziksel buhar biriktirme (PVD) yöntemi ile yapılan ince seramik film
kaplamalar ile ülkemizde henüz uygulaması bulunmayan, ancak üstün yönleri
bakımından kritik teknolojiler arasında yer alan doğrudan buhar biriktirme
(DVD) kaplama yönteminin temel farklılıklarına değinerek, JVD/DVD kaplama
teknolojilerinin üstün teknolojik özelliklerine dikkat çekmektir. Çalışmada, her
iki kaplama yöntemi kavramsal ve sistem özellikleri açısından incelenmiştir.
Her iki yöntemin farkları ortaya konularak, geleceğin kaplama teknolojisi
olarak gösterilen DVD yönteminin ülkemizde uygulanabilirliği araştırılmıştır.

Sonuç olarak, Doğrudan Buhar Biriktirme (DVD) tekniği ile; sürtünmeye,
ısıya ve aşınmaya dayanıklı, yüksek hızlarda çalışan makine elemanlarına,
alaşım ve bileşiklerin düzlemsel ya da eğrisel yüzeylerine üstün özelliklere
sahip ince film kaplama yapılabilmektedir.
I.Dünya Savaşı Öncesi Avustralya Askerî Organizasyonu ve Avustralya İmparatorluk Kuvveti’nin Oluşum Süreci (1870-1914)
Authors: ÖZCAN Orhan 
Published: May 2018

Öz&nbsp;Avustralya topraklarında 1850’li yıllarda altın
madeninin bulunmasıyla, ekonomik düzeyi iyileşen Avustralya, 1868’de Büyük
Britanya’dan gelen son mahkûm yerleşimcileri kabul etmiştir. Bunun üzerine
Büyük Britanya, 1870 yılında Avustralya kolonisinden askerî birliklerinin büyük
bir kısmını geri çekmiştir. Böylece bağımsız olan Avustralya Eyaletleri, yerel
ve kendine has askerî yapısını oluşturmaya girişmiştir. Ancak Asya-Pasifik
bölgesinde Avustralya’nın, gerek Almanya ve Fransa gibi Avrupalı emperyalist güçlerin
gerekse Japonya ve Çin gibi Asya toplumlarından kaynaklı irrasyonel tehdit
algısı, tekrar Büyük Britanya askerî gücüne güvenlik gerekçesiyle ihtiyaç
duymasına neden olmuştur. Bu makalede, I.Dünya Savaşı öncesi (1870-1914)
Avustralya’nın askerî organizasyonunun ve İmparatorluk Kuvveti’nin oluşum
süreci incelenmiştir. Bu kapsamda Avustralya’nın kısa tarihi ve Avustralya
jeopolitiğinin, Avustralya askerî organizasyona etkisi değerlendirilmiş ve
Avustralya’nın federasyon öncesi ve sonrası, Büyük Britanya etkisinde askerî
yapılanması, kurumsallaşması, değişim ve dönüşüm safhaları araştırılmıştır.
Ayrıca Avustralya siyasi elitizminin jeostratejik açıdan dış politikası
bağlamında, Avustralya askerî yapılanmasına tesirleri analiz edilmiştir.

Anahtar
Kelimeler: Avustralya
Tarihi, Avustralya Askerî Organizasyonu, Avustralya İmparatorluk Kuvveti, Büyük
Britanya, I.Dünya Savaşı.&nbsp;