bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Results of Cultured Limbal Stem Cell Versus Limbal Tissue Transplantation in Stage III Limbal Deficiency
Authors: Borderie Vincent M. , Ghoubay Djida , Georgeon Cristina , Borderie Marie , Sousa Céline , Legendre Anne , Rouard Hélène 
Published: September 2019

Abstract
We aimed to evaluate efficiency and safety of transplantation of limbal stem cells (LSC) cultured on human amniotic membrane with no feeders and to compare cultured LSC with limbal tissue transplantation. Thirty eyes with stage III LSC deficiency were treated with autologous (autoLSC) or allogeneic (alloLSC) cultured LSC transplantation (prospective phase II clinical trial; average follow-up time, 72 months) or autologous (autoLT) or allogeneic (alloLT) limbal tissue transplantation (retrospective control group; average follow-up time, 132 months) between 1993 and 2014. The 5-year graft survival defined by absence of recurrence of the clinical signs of limbal deficiency was 71% for autoLSC, 0% for alloLSC, 75% for autoLT, and 33% for alloLT. Visual acuity improved by 9.2 lines for autoLSC and 3.3 lines for autoLT. It decreased by 0.7 lines for alloLSC and 1.9 lines for alloLT. Adverse events were recorded in 1/7 autoLSC, 7/7 alloLSC, 6/8 autoLT, and 8/8 alloLT patients. Corneal epithelial defect was the only adverse event recorded after autoLSC, whereas severe sight-threatening adverse events were recorded in the remaining three groups. Compared with failed grafts, successful grafts featured greater decrease in fluorescein staining, greater superficial vascularization-free corneal area, lower variability of the corneal epithelial thickness, and higher corneal epithelial basal cell density. Autologous cultured LSC transplantation was associated with high long-term survival and dramatic improvement in vision and was very safe. Autologous limbal tissue transplantation resulted in similar efficiency but was less safe. Cadaver allogeneic grafts resulted in low long-term success rate and high prevalence of serious adverse events. Stem Cells Translational Medicine 2019;8:1230&1241
Microwave‐Assisted Synthesis and Biological Evaluation of Some New Pyrazolothiazoles via a Multicomponent Approach
Authors: Mamidala Srikanth , Aravilli R Kowshik , Vaarla Krishnaiah , Vedula Rajeswar Rao 
Published: September 2019

AbstractA series of new pyrazolothiazole hybrids were designed and synthesized by the microwave‐assisted multicomponent reaction of thiosemicarbazide, 3‐(furan‐2‐yl)‐1‐(pyridin‐2‐yl)prop‐2‐en‐1‐one and 1‐(pyridin‐2‐yl)‐3‐(thiophen‐2‐yl)prop‐2‐en‐1‐one with substituted 2‐bromoacetophenones. Structures of all the synthesized compounds were in good agreement with their spectral (FTIR, 1H & 13C NMR, Mass) and analytical data (CHN analysis). The target compounds were screened for their in vitro cytotoxic activity by testing against human adenocarcinoma (A549), cervical cancer (HeLa), human neuroblastoma (SK−N‐SH) and human prostate cancer (DU‐145) cell lines. From the in vitro results, it was found that the compound derived from p‐ NO2 phenyl (4 h) has potent activity against HeLa cell line with IC50 value 9.97 ± 0.05 μM. Also, the compounds having p‐OCH3 phenyl (4 c), phenyl (4 i), and p‐Cl phenyl (4 j) substitutions exhibited significant activity against HeLa cell line with IC50 values 19.78 ± 0.03 μM, 18.47 ± 0.01 μM and 15.61 ± 0.06 μM respectively.
Modified Chitosan as a “Multi‐subtype” Macromolecular Emulsifier for Preparing Asphalt Emulsion
Authors: Hou Runhan , Wang Xiaoxi , Zhang Qian , Han Yuxuan , Zhang Tong , Wang Yuexin 
Published: September 2019

AbstractThe “Multi‐subtype” macromolecular cationic asphalt emulsifier was synthesized based on chitosan (abbreviated as MCTS) via the ring‐opening reaction and quaternization. Then the structure of the emulsifier was characterized by FTIR and 1H‐NMR spectra. Moreover, the surface tension and critical micelle concentration (CMC) of the MCTS were determined from 298 to 313 K. The CMC and γcmc were 0.064 g L−1 and 38.85 mN m−1 at 298 K, respectively, and the lowest surface tension of the solution reached to 26.09 mN m−1 at 313 K. The tested Hydrophile‐Lipophile Balance (HLB) value of MCTS was 10, which can meet the requirement of asphalt emulsifier. Through emulsification experiments, the emulsifying ability of the MCTS was measured, and the results indicated that the emulsifier exhibited excellent application for asphalt. It may be caused by that the MCTS containing polar bundle groups could enhance the interaction between polar asphaltene and the emulsifier solution. Moreover, the prepared asphalt emulsion was more stable compared to the emulsion prepared by Gemini emulsifier. The demulsification experiments were also correspondingly done for emulsified asphalt. All the results showed that the MCTS has potential applications in the preparation of asphalt emulsion.
Hirshfeld Surface, Molecular Docking Study, Spectroscopic Characterization and NLO Profile of 2‐Methoxy‐4,6‐Diphenylnicotinonitrile
Authors: Gökce Halil , Sert Yusuf , Alpaslan Gökhan , El‐Azab Adel S. , Alanazi Mohammed M. , Al‐Agamy Mohamed H.M. , Abdel‐Aziz Alaa A.‐M. 
Published: September 2019

AbstractThe compound 2‐methoxy‐4,6‐diphenylnicotinonitrile was characterized by using experimental FT‐IR, Laser‐Raman,1H and13C NMR spectra and UV‐Vis. spectroscopic analysis methods. To support experimental structural, vibrational, chemical shift and electronic records, the theoretical analyses were performed at the DFT/B3LYP method with the 6–311++G(2d,2p) basis set. The π⋅⋅⋅π, N⋅⋅⋅π, N⋅⋅⋅H, C⋅⋅⋅H and O⋅⋅⋅H interactions within crystal packing of the compound, which aren't taken into account within the experimental single crystal X‐Ray diffraction study, were investigated in detail with Hirshfeld surface analyses and their related 2D fingerprint plots. The highest occupied molecular orbital (HOMO), the lowest unoccupied molecular orbital (LUMO) and their associated parameters were used to explain intra‐molecular charge transfer and global reactivity properties of the compound with the computational level of theory. Non‐linear optical (NLO) profile of the title compound including π electron systems such as aromatic and cyano groups was determined by considering the static polarizability (α) and the static first‐order hyperpolarizability (β) values. Molecular docking analysis was performed to determine intermolecular interactions between a Mps1/TTK protein kinase inhibitor with the title compound.
Probabilistic studies on mechanics‐based shear capacity models for reinforced concrete beams with stirrups
Authors: Nagavedu Jayakumar Yogalakshmi , Kanchi Balaji Rao 
Published: September 2019

AbstractThe efficiency of shear capacity models of reinforced concrete beams with stirrups depends on the assumed mechanism and in few cases depends also on critical shear crack angle prediction. In the present study, three mechanics‐based shear capacity models (the limit analysis‐based models presented by Nielsen and Hoang, and the Mari et al. model) are considered covering the range space of shear span to effective depth ratios greater than 2.5. The statistics of modeling error associated with these models are determined using the database created in this study. The database contains limited results of experimental investigations, available in literature, on shear capacity of reinforced concrete beams with stirrups. The randomness in shear capacity is quantified by performing probabilistic analysis of one set of nominally similar beams taken from the database. Based on the shear capacity distribution obtained, characteristic design equations of reinforced concrete beams are proposed. The results of reliability analyses show that the reliability of a beam, for a given mean live to dead load ratio, varies when different shear capacity models are used in the analysis. Thus, calibration studies need to be performed for selecting a model for design.
Are catchments leaky?
Authors: Fan Ying 
Published: September 2019

AbstractCatchments, generally understood as the drainage areas of low‐order streams, are often regarded as closed hydrologic entities; that is, precipitation (P) minus evapotranspiration (ET) over a catchment equates stream outflow (Q
r). Here, we review evidence that catchments can be leaky due to groundwater outflow or inflow across topographic divides, based on catchment mass balance across a continent and several site‐based studies across the globe. It appears that a catchment is more likely to be leaky with the combination of the following factors: small catchment size, positioned at either the high or low end of a steep regional topographic and climatic gradient, underlain by deep permeable substrates that extend beyond the study catchment, and in drier climate or dry seasons and droughts. Catchment leakage has hydrological, geochemical, and ecological implications. Thus, catchments are best framed as semiclosed hydrologic units perched on top of a larger, regional hydrogeological system with no real boundaries regarding the movement of water and solutes.This article is categorized under:
Science of Water > Hydrological Processes
Water and Life > Nature of Freshwater Ecosystems
Private lands conservation: A vision for the future
Authors: Burger L. Wes , Evans Kristine O. , McConnell Mark D. , Burger Leslie M. 
Published: September 2019

ABSTRACTAgricultural production, including croplands, pasture, and timber, dominates private‐land use and land cover across much of the contiguous lower 48 states. These private lands are essential to achieving the goals of national conservation initiatives such as the Northern Bobwhite Conservation Initiative (bobwhite [Colinus virginianus]), Sage Grouse Initiative, and North American Waterfowl Management Plan. Effective conservation delivery in managed landscapes requires 1) an understanding of landowner priorities and ownership objectives, 2) knowledge of the economic and environmental costs and benefits of conservation, and 3) natural resource professionals who understand the business of agriculture and forestry as well as principles of habitat management and wildlife conservation. We make the case for a new vision of multifunctional working landscapes that include designed components of natural and seminatural noncrop perennial plant communities (wetlands, grasslands, riparian areas, field margins, pine [Pinus spp.] grasslands, savannas, etc.) embedded in a matrix of row‐crop, pasture, rangeland, and forested working lands that produce sustainable food, fiber, and fuel. Producing sustainable, multifunctional landscapes will require effective conservation delivery that is intentional, objective‐driven, targeted, science‐based, and landscape scale. We contend that it will also require a new kind of natural resource professional. We consider the specific and novel skill sets that will be required among natural resource professionals to deliver conservation to private owners–producers of working lands. © 2019 The Wildlife Society.
Delivery of habitat conservation programs on private land
Authors: Riley Terry Z. , Marymor Noe , Riley Nancy D. , White Bill 
Published: September 2019

ABSTRACTState Wildlife Action Plans serve as blueprints for conserving our nation's fish and wildlife and preventing endangered species listings. These plans guide conservation of >12,000 species in greatest conservation need. Recovering these species will require a dramatic increase in funding. The majority of these habitat‐restoration efforts will have to be located on private land, particularly in the eastern two‐thirds of the United States. A wide variety of state and federal habitat conservation programs and associated funding sources already exist, but current funding mechanisms appear to be inadequate to meet conservation needs, and delivery mechanisms are duplicative. Coordination is difficult for state and federal natural resource agencies, which can lead to inefficiency and redundancy among programs. Successful conservation depends on the collaboration of many individuals, government agencies, and nongovernmental organizations. Conservation program efficiency can be improved by expanding, strengthening, and simplifying partnerships. We believe federal natural‐resource agencies should transfer funds to states through block grants and technical‐service provider agreements to manage and protect habitats for threatened and endangered species, migratory birds, and other federal‐trust species primarily through conservation delivery on private lands. © 2019 The Wildlife Society.
Stringy (Galilei) Newton-Hooke Chern-Simons gravities
Authors: Avilés Luis , Gomis Joaquim , Hidalgo Diego 
Published: September 2019

AbstractWe construct Chern-Simons gravities in (2 + 1)-dimensional space-time considering the Stringy Galilei algebra both with and without non-central extensions. In the first case, there is an invariant and non-degenerate bilinear form, however the field equations do not allow to express the spin connections in terms of the dreibeins. In the second case there is no invariant non-degenerate bilinear form. Therefore, in both cases we do not have an ordinary gravity theory. Instead, if we consider the stringy Newton-Hooke algebra with extensions as gauge group we have an invariant non-degenerate metric and from the field equations we express the spin connections in terms of the geometric fields.
Arthroscopic primary repair of proximal anterior cruciate ligament tears seems safe but higher level of evidence is needed: a systematic review and meta-analysis of recent literature
Authors: van der List Jelle P. , Vermeijden Harmen D. , Sierevelt Inger N. , DiFelice Gregory S. , van Noort Arthur , Kerkhoffs Gino M. M. J. 
Published: September 2019

AbstractPurposeTo assess the outcomes of the various techniques of primary repair of proximal anterior cruciate ligament (ACL) tears in the recent literature using a systematic review with meta-analysis.MethodsPRISMA guidelines were followed. All studies reporting outcomes of arthroscopic primary repair of proximal ACL tears using primary repair, repair with static (suture) augmentation and dynamic augmentation between January 2014 and July 2019 in PubMed, Embase and Cochrane were identified and included. Primary outcomes were failure rates and reoperation rates, and secondary outcomes were patient-reported outcome scores.ResultsA total of 13 studies and 1,101 patients (mean age 31 years, mean follow-up 2.1 years, 60% male) were included. Nearly all studies were retrospective studies without a control group and only one randomized study was identified. Grade of recommendation for primary repair was weak. There were 9 out of 74 failures following primary repair (10%), 6 out of 69 following repair with static augmentation (7%) and 106 out of 958 following dynamic augmentation (11%). Repair with dynamic augmentation had more reoperations (99; 10%), and more hardware removal (255; 29%) compared to the other procedures. All functional outcome scores were > 85% of maximum scores.ConclusionsThis systematic review with meta-analysis found that the different techniques of primary repair are safe with failure rates of 7–11%, no complications and functional outcome scores of > 85% of maximum scores. There was a high risk of bias and follow-up was short with 2.1 years. Prospective studies comparing the outcomes to ACL reconstruction with sufficient follow-up are needed prior to widespread implementation.Level of evidenceIV.
Glider automorphisms and a finitary Ryan’s theorem for transitive subshifts of finite type
Authors: Kopra Johan 
Published: September 2019

Abstract
For any mixing SFT X we construct a reversible shift-commuting continuous map (automorphism) which breaks any given finite point of the subshift into a finite collection of gliders traveling into opposing directions. As an application we prove a finitary Ryan’s theorem: the automorphism group $${{\,\mathrm{Aut}\,}}(X)$$

Aut

(
X
)

contains a two-element subset S whose centralizer consists only of shift maps. We also give an example which shows that a stronger finitary variant of Ryan’s theorem does not hold even for the binary full shift.
An improvement in MATSim computing time for large-scale travel behaviour microsimulation
Authors: Zhuge Chengxiang , Bithell Mike , Shao Chunfu , Li Xia , Gao Jian 
Published: September 2019

AbstractCoupling activity-based models with dynamic traffic assignment appears to form a promising approach to investigating travel demand. However, such an integrated framework is generally time-consuming, especially for large-scale scenarios. This paper attempts to improve the performance of these kinds of integrated frameworks through some simple adjustments using MATSim as an example. We focus on two specific areas of the model—replanning and time stepping. In the first case we adjust the scoring system for agents to use in assessing their travel plans to include only agents with low plan scores, rather than selecting agents at random, as is the case in the current model. Secondly, we vary the model time step to account for network loading in the execution module of MATSim. The city of Baoding, China is used as a case study. The performance of the proposed methods was assessed through comparison between the improved and original MATSim, calibrated using Cadyts. The results suggest that the first solution can significantly decrease the computing time at the cost of slight increase of model error, but the second solution makes the improved MATSim outperform the original one, both in terms of computing time and model accuracy; Integrating all new proposed methods takes still less computing time and obtains relatively accurate outcomes, compared with those only incorporating one new method.
Inter-organizational collaboration for energy efficiency in the maritime sector: the case of a database project
Authors: Borg Josefin , von Knorring Hannes 
Published: September 2019

AbstractThis article explores the complexities of establishing knowledge-sharing practices between organizations through a case study of the creation of a database for energy efficiency measures relevant to the shipping sector. As researchers and policy-makers tend to point towards knowledge sharing and collaboration as means towards a more energy-efficient society, there is a need to better understand the knowledge sharing practices in such initiatives. The study is based upon extensive fieldwork where the first author was recruited to a collaborative network on energy efficiency in the shipping sector, to aid in the development of the collaboration while carrying out participatory-observational research in an ethnographic tradition. The study highlights the need to maintain realistic expectations for new knowledge-sharing collaborations, and the necessity to allow such arrangements to develop over time.
Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology
Authors: Barupal Dinesh Kumar , Baillie Rebecca , Fan Sili , Saykin Andrew J. , Meikle Peter J. , Arnold Matthias , Nho Kwangsik , Fiehn Oliver , Kaddurah‐Daouk Rima ,   Alzheimer's Disease Neuroimaging Initiative,   Alzheimer Disease Metabolomics Consortium
Published: September 2019

AbstractIntroductionComorbidity with metabolic diseases indicates that lipid metabolism plays a role in the etiology of Alzheimer's disease (AD). Comprehensive lipidomic analysis can provide new insights into the altered lipid metabolism in AD.MethodIn this study, a total 349 serum lipids were measured in 806 participants enrolled in the Alzheimer's Disease Neuroimaging Initiative Phase 1 cohort and analyzed using lipid‐set enrichment statistics, a data mining method to find coregulated lipid sets.ResultsWe found that sets of blood lipids were associated with current AD biomarkers and with AD clinical symptoms. AD diagnosis was associated with 7 of 28 lipid sets of which four also correlated with cognitive decline, including polyunsaturated fatty acids. Cerebrospinal fluid amyloid beta (Aβ1‐42) correlated with glucosylceramides, lysophosphatidylcholines and unsaturated triacylglycerides; cerebrospinal fluid total tau and brain atrophy correlated with monounsaturated sphingomyelins and ceramides, in addition to EPA‐containing lipids.DiscussionAD‐associated lipid sets indicated that lipid desaturation, elongation, and acyl chain remodeling processes are disturbed in AD subjects. Monounsaturated lipid metabolism was important in early stages of AD, whereas the polyunsaturated lipid metabolism was associated with later stages of AD. Our study provides several new hypotheses for studying the role of lipid metabolism in AD.
Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions
Authors: Kong Weili , Hayashi Tsuyoshi , Fiches Guillaume , Xu Qikai , Li Mamie Z. , Que Jianwen , Liu Shuai , Zhang Wei , Qi Jun , Santoso Netty , Elledge Stephen J. , Zhu Jian 
Published: September 2019

Abstract
Proteins usually associate with other molecules physically to execute their functions. Identifying these interactions is important for the functional analysis of proteins. Previously, we reported the parallel analysis of translated ORFs (PLATO) to couple ribosome display of full-length ORFs with affinity enrichment of mRNA/protein/ribosome complexes for the “bait” molecules, followed by the deep sequencing analysis of mRNA. However, the sample processing, from extraction of precipitated mRNA to generation of DNA libraries, includes numerous steps, which is tedious and may cause the loss of materials. Barcoded PLATO (PLATO-BC), an improved platform was further developed to test its application for protein interaction discovery. In this report, we tested the antisera-antigen interaction using serum samples from patients with inclusion body myositis (IBM). Tripartite motif containing 21 (TRIM21) was identified as a potentially new IBM autoantigen. We also expanded the application of PLATO-BC to identify protein interactions for JQ1, single ubiquitin peptide, and NS5 protein of Zika virus. From PLATO-BC analyses, we identified new protein interactions for these “bait” molecules. We demonstrate that Ewing sarcoma breakpoint region 1 (EWSR1) binds to JQ1 and their interactions may interrupt the EWSR1 association with acetylated histone H4. RIO kinase 3 (RIOK3), a newly identified ubiquitin-binding protein, is preferentially associated with K63-ubiquitin chain. We also find that Zika NS5 protein interacts with two previously unreported host proteins, par-3 family cell polarity regulator (PARD3) and chromosome 19 open reading frame 53 (C19orf53), whose attenuated expression benefits the replication of Zika virus. These results further demonstrate that PLATO-BC is capable of identifying novel protein interactions for various types of “bait” molecules.