bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Simulation-Based versus Live Tissue–Based Ocular Trauma Training on Novice Ophthalmologists: Repair of Marginal Eyelid Laceration Model
Authors: Sykes Sean , Chou Eva , Mazzoli Robert , Pasternak Joseph , Ryan Denise , Sia Rose , Colyer Marcus 
Published: May 2018

Introduction Simulation training in medical education provides the ability to teach valuable surgical skills in an environment free of risk to patients. Surgical simulation in ophthalmology continues to evolve as new technologies advance, though widespread use in ophthalmology outside of cataract surgery simulation is lacking. Here, we present a study into the efficacy of surgical simulation for eyelid laceration repair when compared with standard tissue-based instruction.
Materials and Methods The study included 43 ophthalmology residents and 16 staff ophthalmologists from the Ocular Trauma Surgery Laboratory (OTSL) at the Uniformed Services University of the Health Sciences (USUHS). After initial evaluation on their ability to repair marginal eyelid lacerations on a porcine eye, residents were randomized to receive training in marginal eyelid repair technique from faculty preceptors using either traditional porcine tissue or the Ocular and Craniofacial Trauma Treatment Training System (Medical Device and Simulation Laboratory). They were then reevaluated after training. Participating staff also underwent initial evaluation, self-guided training, and post-training evaluation. Outcome measures included successful repair of laceration, number of sutures required to close a 10-mm wound, time required to repair, and the following graded on a scale of 1–4 (1—poor, 2—fair, 3—good, 4—excellent): tarsal plate reconstruction and margin approximation.
Results Among residents, improved scores in marginal approximation were noted after training when comparing scores both within the simulator-trained group (pre-training score: 2.0, post-training score: 3.0; p = 0.03) and between the simulator (SIM) and live tissue (LIVE) groups (SIM: 3.0, LIVE: 2.0 p = 0.03). Neither residents nor staff demonstrated significant differences between SIM versus LIVE in other metrics evaluated. Response in a post-study survey was favorable to simulator training, with 79% noting the simulator was helpful in teaching skills, and 83% noting they would use the simulator again.
Conclusion Simulator technology for teaching marginal eyelid laceration repair appears to be noninferior to traditional tissue-based instruction. Additionally, it appears to be superior when evaluating the ability to approximate the eyelid margin appropriately. Simulators are safe and ethical alternatives to tissue-based instruction, and are favorably received among trainees, and therefore warrant additional investigation and development for ophthalmic surgical training.
Comprehensive Surgical Strategies for the Management of Pachydermoperiostosis
Authors: Taichao Du , Fuling Luo , Hengguang Zhao 
Published: May 2018

AbstractThe cosmetic and functional deformities induced by thickened folds and furrows are the main complaints of patients in pachydermoperiostosis (PDP). However, traditional drug therapy only has a limited effect for its unclear genetic pathogenesis. Surgical treatment has now become one of the optimal strategies mainly aiming for its cosmetic improvement. Here we describe a comprehensive management of PDP approached with surgical procedure thereby showing markedly improved cosmetic outcome. Experientially, the surgical treatment of PDP is effective and may be preferentially recommended for PDP patients especially of severe degree.
Car Travel-Related Thrombosis: Fact or Fiction?
Authors: Favaloro Emmanuel , Lippi Giuseppe 
Published: May 2018

AbstractThe condition sometimes referred to as “economy class syndrome,” and also known as “traveler's thrombosis,” is a distinctive pathological condition characterized by occurrence of venous thromboembolism (VTE) in a patient who has recently experienced a long journey (i.e., ≥ 4 h). Typically, the identified travel is by airplane, but travel with other vehicles, such as trains, trucks, buses, or cars, could potentially qualify as contributing to VTE events. Although the enhanced risk of VTE after long haul flights is now widely acknowledged, albeit potentially overhyped, the risk of venous thrombosis after prolonged travel by other modes of transport, in particular, by cars, is less well appreciated. Current evidence, collected from some epidemiological studies, suggests that if any risk of VTE can be attributed to prolonged and uninterrupted car travels, and we give moderate credibility to such an association, the risk may be similar to that already proven for long haul flights. The risk is especially high in individuals undergoing uninterrupted car journeys lasting 4 hours or longer, in vehicles with a narrow seat-pitch, and in particularly would affect those with pre-existing acquired or inherited prothrombotic conditions. The putative biological mechanisms basically entail venous stasis and edema, which are often compounded by a certain degree of hypercoagulability. When these factors are combined with preexistent prothrombotic conditions, the risk may be substantially magnified. In this perspective, then, ‘car thrombosis’ may be regarded as a trigger rather than a risk factor for venous thrombosis. Although the current evidence is certainly not solid enough to endorse the use of general chemical prophylaxis for lowering the risk of car-related VTE, a set of possible precautionary measures, with no or very little side effects, may be suggested before planning prolonged car travels, especially for at risk individuals.
Torque Teno Virus in HIV-infected transgender in Surakarta, Indonesia
Authors: Hartono  , Prasetyo Afiono Agung , Fanani Mohammad 
Published: May 2018

Abstract
Torque Teno Virus (TTV) is a circular single-stranded DNA virus that may co-infected with human immunodeficiency virus (HIV), especially in the high-risk community e.g. the transgender performing high-riskbehavior. TTV shows an increased viremia in HIV patients and maybe influence the HIV clinical progression. Blood samples collected from transgender performing high-riskbehavior in Surakarta were tested by serological and molecular assays to detect the presence of HIV infection. The blood samples with HIV positive status were then tested by a nested polymerase chain reaction (PCR) to detect the presentation of TTV DNA. The amplified PCR products were molecularly cloned and subjected to sequence analysis. TTV DNA was detected in 40.0% HIV-positive samples. The molecular characterization revealed that the most prevalent was genogroup 3, followed by genogroup 2 and 1, respectively. TTV was detected in HIV-infected transgender performing high-riskbehavior in Surakarta with high infection rate.
Molecular analysis of Toxoplasma gondii Surface Antigen 1 (SAG1) gene cloned from Toxoplasma gondii DNA isolated from Javanese acute toxoplasmosis
Authors: Haryati Sri , Prasetyo Afiono Agung , Sari Yulia , Dharmawan Ruben 
Published: May 2018

Abstract

Toxoplasma gondii Surface Antigen 1 (SAG1) is often used as a diagnostic tool due to its immunodominant-specific as antigen. However, data of the Toxoplasma gondii SAG1 protein from Indonesian isolate is limited. To study the protein, genomic DNA was isolated from a Javanese acute toxoplasmosis blood samples patient. A complete coding sequence of Toxoplasma gondii SAG1 was cloned and inserted into an Escherichia coli expression plasmid and sequenced. The sequencing results were subjected to bioinformatics analysis. The Toxoplasma gondii SAG1 complete coding sequences were successfully cloned. Physicochemical analysis revealed the 336 aa of SAG1 had 34.7 kDa of weight. The isoelectric point and aliphatic index were 8.4 and 78.4, respectively. The N-terminal methionine half-life in Escherichia coli was more than 10 hours. The antigenicity, secondary structure, and identification of the HLA binding motifs also had been discussed. The results of this study would contribute information about Toxoplasma gondii SAG1 and benefits for further works willing to develop diagnostic and therapeutic strategies against the parasite.
Re‐Examining the SNAP Benefit Cycle Allowing for Heterogeneity
Authors: Dorfman Jeffrey H , Gregory Christian , Liu Zhongyuan , Huo Ran 
Published: May 2018

AbstractA well‐known feature of the Supplemental Nutrition Assistance Program (SNAP) is that some recipients spend a disproportionate amount of their monthly benefit early in the month. Using a finite mixture model that optimally separates households into two groups, coupled with the National Household Food Acquisition and Purchase Survey, we re‐examine this spending pattern. Results show that a minority of SNAP recipients cause the benefit cycle by spending, on average, two‐thirds of their monthly benefit within the first four days. A potential implication of these findings is that more frequent SNAP benefit disbursal or educational programs designed to encourage smoother spending over the month might be of benefit to some SNAP households.
Estimating Willingness to Pay for E85 in the United States Using an Intercept Survey of Flex Motorists
Authors: Pouliot Sébastien , Liao Kenneth A. , Babcock Bruce A. 
Published: May 2018

AbstractCompliance with the Renewable Fuel Standard (RFS) in the United States will require price incentives for a substantial number of motorists with flex‐fuel vehicles to switch to high ethanol‐gasoline blends. Existing estimates of motorists’ willingness to pay for high‐ethanol blends use data from Brazil, data generated when prices greatly favored low‐ethanol blends, or stated preference data collected from mail and online surveys. We conducted an intercept survey of flex motorists as they refueled in five U.S. states. We overcome the problem caused by sample prices favoring low‐ethanol blends by augmenting revealed preference data with stated preference data. A sample‐selection problem arises because motorists with high willingness to pay seek out the relatively few stations that sell high‐ethanol blends. We use responses from two questions to inform sample selection. We find the average U.S. motorist requires a substantial discount to switch to high ethanol blends beyond the price that equates the cost per mile of driving.
Trajectories of Aging Among U.S. Older Adults: Mixed Evidence for a Hispanic Paradox
Authors: Tarraf Wassim , Jensen Gail A , Dillaway Heather E , Vásquez Priscilla M , González Hector M 
Published: May 2018

Abstract

Objectives
A well-documented paradox is that Hispanics tend to live longer than non-Hispanic Whites (NHW), despite structural disadvantages. We evaluate whether the “Hispanic paradox” extends to more comprehensive longitudinal aging classifications and examine how lifecourse factors relate to these groupings.

Methods
We used biennial data (1998–2014) on adults aged 65 years and older at baseline from the Health and Retirement Study. We use joint latent class discrete time and growth curve modeling to identify trajectories of aging, and multinomial logit models to determine whether U.S.-born (USB-H) and Foreign-born (FB-H) Hispanics experience healthier styles of aging than non-Hispanic Whites (NHW), and test how lifecycle factors influence this relationship.

Results
We identify four trajectory classes including, “cognitive unhealthy,” “high morbidity,” “nonaccelerated”, and “healthy.” Compared to NHWs, both USB-H and FB-H have higher relative risk ratios (RRR) of “cognitive unhealthy” and “high morbidity” classifications, relative to “nonaccelerated.” These patterns persist upon controlling for lifecourse factors. Both Hispanic groups, however, also have higher RRRs for “healthy” classification (vs “nonaccelerated”) upon adjusting for adult achievements and health behaviors.

Discussion
Controlling for lifefcourse factors USB-H and FB-H have equal or higher likelihood for “high morbidity” and “cognitive unhealthy” classifications, respectively, relative to NHWs. Yet, both groups are equally likely of being in the “healthy” group compared to NHWs. These segregations into healthy and unhealthy groups require more research and could contribute to explaining the paradoxical patterns produced when population heterogeneity is not taken into account.
Regulation dynamics of exploited and protected populations of Haliotis roei, and their response to a marine heatwave
Authors: Hart Anthony M , Strain Lachlan W S , Brown Jamin 
Published: May 2018

AbstractExploited and protected populations of Haliotis roei in Western Australia were significantly perturbed by a marine heatwave of 2010/11. The immediate effects were a decline in large animals and recruitment, followed by a lagged decline in the spawning biomass. The data describing these effects were fitted to models of the population dynamic transitions. Depensatory density dependence in recruitment is offset by compensatory density dependence in during replacement and together they create the population equilibrium points. Equilibrium densities were highly influenced by the environmental perturbation, with observed patterns suggesting a temporary ‘regime shift’ had occurred. The main implication for management is to maximise spawning biomass as recruitment is positively correlated with it with some evidence of an Allee effect at low spawning densities, but no evidence of compensatory density dependence at high densities. Development of forecasting models that utilised pre-recruit densities, adjusted for density-dependent replacement, and incorporated an environmental effect, assisted early-management intervention to stock declines. Such an approach is an alternative to traditional assessments which recommend using biological reference points that assume population regulation occurs in the recruitment transition. This assumption cannot easily explain why the high density unfished stock showed the least resilience to the environmental perturbation.
Patient similarity by joint matrix trifactorization to identify subgroups in acute myeloid leukemia
Authors: Vitali F , Marini S , Pala D , Demartini A , Montoli S , Zambelli A , Bellazzi R 
Published: May 2018

Abstract

Objective
Computing patients’ similarity is of great interest in precision oncology since it supports clustering and subgroup identification, eventually leading to tailored therapies. The availability of large amounts of biomedical data, characterized by large feature sets and sparse content, motivates the development of new methods to compute patient similarities able to fuse heterogeneous data sources with the available knowledge.

Materials and Methods
In this work, we developed a data integration approach based on matrix trifactorization to compute patient similarities by integrating several sources of data and knowledge. We assess the accuracy of the proposed method: (1) on several synthetic data sets which similarity structures are affected by increasing levels of noise and data sparsity, and (2) on a real data set coming from an acute myeloid leukemia (AML) study. The results obtained are finally compared with the ones of traditional similarity calculation methods.

Results
In the analysis of the synthetic data set, where the ground truth is known, we measured the capability of reconstructing the correct clusters, while in the AML study we evaluated the Kaplan-Meier curves obtained with the different clusters and measured their statistical difference by means of the log-rank test. In presence of noise and sparse data, our data integration method outperform other techniques, both in the synthetic and in the AML data.

Discussion
In case of multiple heterogeneous data sources, a matrix trifactorization technique can successfully fuse all the information in a joint model. We demonstrated how this approach can be efficiently applied to discover meaningful patient similarities and therefore may be considered a reliable data driven strategy for the definition of new research hypothesis for precision oncology.

Conclusion
The better performance of the proposed approach presents an advantage over previous methods to provide accurate patient similarities supporting precision medicine.
FTO is a transcriptional repressor to auto-regulate its own gene and potentially associated with homeostasis of body weight
Authors: Liu Shu-Jing , Tang Hui-Ling , He Qian , Lu Ping , Fu Tao , Xu Xu-Ling , Su Tao , Gao Mei-Mei , Duan Shumin , Luo Yan , Long Yue-Sheng 
Published: May 2018

Abstract
Fat mass and obesity-associated (FTO) protein is a ferrous ion (Fe2+)/2-oxoglutarate (2-OG)-dependent demethylase preferentially catalyzing m6A sites in RNA. The FTO gene is highly expressed in the hypothalamus with fluctuation in response to various nutritional conditions, which is believed to be involved in the control of whole body metabolism. However, the underlying mechanism in response to different nutritional cues remains poorly understood. Here we show that ketogenic diet-derived ketone body β-hydroxybutyrate (BHB) transiently increases FTO expression in both mouse hypothalamus and cultured cells. Interestingly, the FTO protein represses Fto promoter activity, which can be offset by BHB. We then demonstrate that FTO binds to its own gene promoter, and Fe2+, but not 2-OG, impedes this binding and increases FTO expression. The BHB-induced occupancy of the promoter by FTO influences the assembly of the basal transcriptional machinery. Importantly, a loss-of-function FTO mutant (I367F), which induces a lean phenotype in FTOI367F mice, exhibits augmented binding and elevated potency to repress the promoter. Furthermore, FTO fails to bind to its own promoter that promotes FTO expression in the hypothalamus of high-fat diet-induced obese and 48-h fasting mice, suggesting a disruption of the stable expression of this gene. Taken together, this study uncovers a new function of FTO as a Fe2+-sensitive transcriptional repressor dictating its own gene switch to form an auto-regulatory loop that may link with the hypothalamic control of body weight.
Impact of Outpatient vs Inpatient ABSSSI Treatment on Outcomes: A Retrospective Observational Analysis of Medical Charts Across US Emergency Departments
Authors: Bookstaver P Brandon , Jenkins Timothy C , Stenehjem Edward , Doron Shira , Brown Jack , Goldwater Shannon H , Lopes Carlos , Haynes Angela , Udeze Chuka , Mo Yifan , Gillard Patrick , Liu Yan , Keyloun Katelyn 
Published: May 2018

Abstract

Background
The objective of this study was to characterize treatment of patients with acute bacterial skin and skin structure infections (ABSSSIs) and describe the association between hospital admission and emergency department (ED) visits or readmissions within 30 days after initial episode of care (IEC).

Methods
This was a retrospective, observational, cohort study of adults with ABSSSI who presented to an ED between July 1, 2012, and June 30, 2013. Patient, health care facility, and treatment characteristics, including unplanned ED visits or readmissions, were obtained through manual chart review and abstraction. Adjusted logistic regression analysis examined likelihood of all-cause unplanned ED visits or readmissions between admitted and nonadmitted patients.

Results
Records from 1527 ED visits for ABSSSI from 40 centers were reviewed (admitted, n = 578 [38%]; nonadmitted, n = 949 [62%]). Admitted patients were typically older (mean age, 52.2 years vs 43.0 years), more likely to be morbidly obese (body mass index &gt; 40 kg/m2; 17.3% vs 9.1%), and had more comorbidities (Charlson Comorbidity Index ≥ 4; 24.4% vs 6.8%) compared with those not admitted. In the primary analysis, adjusted logistic regression, controlling for comorbidities and severity of illness, demonstrated that there was a similar likelihood of all-cause unplanned ED visits or readmissions between admitted and nonadmitted patients (odds ratio, 1.03; 95% confidence interval, 0.74–1.43; P = .87).

Conclusions
ABSSSI treatment pathways leveraging outpatient treatment vs hospital admission support similar likelihood of unplanned 30-day ED visits or readmissions, an important clinical outcome and quality metric at US hospitals. Further research regarding the decision criteria around hospital admission to avoid potentially unnecessary hospitalizations is warranted.
Hypertension guideline update
Authors: DePalma Sondra M. , Himmelfarb Cheryl Dennison , MacLaughlin Eric J. , Taler Sandra J. 
Published: May 2018

ABSTRACT
In the United States, hypertension affects about one-third of adults and contributes to one out of every seven deaths. Evidence-based treatment is associated with reductions in incidence of stroke, myocardial infarction, and heart failure as well as associated disability and death. This article reviews the ACC/AHA Task Force on Clinical Practice Guidelines' 2017 Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. Key changes include reclassification of BP stages and lowering of hypertension treatment goals.
High-intensity Interval Training and Continuous Aerobic Exercise Interventions to Promote Self-initiated Quit Attempts in Young Adults Who Smoke: Feasibility, Acceptability, and Lessons Learned From a Randomized Pilot Trial
Authors: Allen Alicia , Carlson Samantha C. , Bosch Tyler A. , Eberly Lynn E. , Okuyemi Kola , Nair Uma , Gordon Judith S. 
Published: May 2018

Objectives:
While exercise significantly reduces craving for cigarettes, the effect of exercise on self-initiation of quit attempts is less known. Therefore, this randomized pilot study explored the effect of starting an exercise program on self-initiated quit attempts, and also the feasibility and acceptability of a novel exercise intervention, high-intensity interval training (HIIT), as compared with a more traditional continuous aerobic (CA) exercise intervention.

Methods:
Participants smoked (≥5 cigarettes/d), were aged 18 to 40 years, and wanted to increase their exercise. Participants were randomized into 1 of 3 groups: HIIT, CA, and delayed control. All participants attended follow-up visits at weeks 4, 8, and 12. Outcomes included measures of feasibility (eg, visit attendance) and acceptability (eg, satisfaction), and also changes in smoking behavior (eg, quit attempts during follow-up) and proxies to quit attempts (eg, positive affect).

Results:
Overall, there were no differences in terms of feasibility and acceptability between the HITT (n = 12) and CA (n = 9) groups. Based on both self-report and objective measurement, the exercise groups (HIIT and CA) increased their physical activity as compared with the delayed treatment group (n = 11). Compared with HIIT and delayed control, CA (n = 9) had significant favorable changes in positive affect (eg, at week 8, HIIT: +0.25 ± 2.21, delayed control: −5.11 ± 2.23, CA: +5.50 ± 2.23; P = 0.0153).

Conclusions:
These observations suggest that HIIT is as feasible and acceptable as CA, though CA may have a more favorable effect on proxies to quit attempts (eg, positive affect). Fully powered studies are needed to examine the effect of HIIT versus CA on quit attempts.