bluuebunny/crossref_metadata_2025_split huggingface dataset:
EVALUATION OF GLUTATHIONE PEROXIDASE ACTIVITY, MALONYLALDEHYDE AND SELENIUM LEVELS IN SICKLE CELL ANAEMIA INDIVIDUALS ATTENDING NAUTH, NNEWI IN SOUTH-EASTERN NIGERIA.
Authors: Nnaemeka Wuraola Serah , Olisekodiaka Madu Japhet , Onuegbu Anaelechi Jude , Aneke Chinawaeze John , Obi Ejeatuluchukwu-alo 
Published: December 2024

Background: Oxidative stress is an imbalance between the production and clearance of toxic free radicals known as reactive oxygen species (ROS). It is associated with hemolysis, a hallmark of SCD. SCD has long been recognized as an inflammatory condition and oxidative stress play important role in pathophysiology of SCA. Imbalance between production and elimination of reactive oxygen species (ROS) damages cell structures, including lipids, membranes, proteins and nucleic acids resulting in cell death or altered cell function.
Aim: The aim of this study was to measure the serum level of Glutathione peroxidase,
Malonaldehyde and Selenium in SCA (HbSS) in their steady state, AA (Healthy adult) and AS (sickle cell carriers)
Methods: This is a cross- sectional study. A total of one hundred and fifty aged matched participants were recruited for this study.50 SCA subjects with sickle cell anemia (SS). Glutathione peroxidase and Malonyaldehyde were measured using turbidometry and colorimetric methods respectively while Selenium was analysed using Atomic Absorption Spectrophotometry (AAS)
Results: The result of analysis of variance (ANOVA) showed that the mean serum level of MDA concentration (2.97±0.29) was higher in the SS group and was statistically significant (p< 0.05). MDA concentration was lower in the AS group. In the post hoc analysis MDA was statistically significant between SS vs AS and AA vs AA. The glutathione peroxidase activity was significantly lower in the SS group (0.85±0.12) compare with the mean values obtained in the AA and AS group. The GPx activity among the three groups was statistically significant while the post hoc analysis among the three groups showed statistical difference and was significant (p < 0.005) The Selenium levels in the SS group is lower compared with the values observed between the AA and AS group. The Se levels in the SS group was statistically lower (5.73±1.34) (p < 0.05) and showed significant difference. The comparison study between AS vs SS and AA vs AA were statistically significant.
Conclusion: The decrease in selenium level potentiates low and weakened antioxidant activity and capacity which also is a reflection of low level of glutathione peroxidase observed which is supposed to attack free radicals to prevent oxidative stress. The findings from this study are in tandem with other researches suggesting that the pathophysiology of sickle cell disease is associated with oxidative stress
Winter Editorial 2024
Authors: Bhangu Aneel 
Published: December 2024

Impact Surgery reaches the end of its first year with six successful issues. I’d like to thank all the authors and wider community for marking this earlier milestone. The next step is to attract more research and secure at least size more issues for 2025. Indexing at the end of 2025 is then the major target and will mark the next era. As an open access journal, we will remain free until that point, although costs are increasing. Our metrics are growing and our rejection rate is steadily increasing as more manuscripts are considered.
التجديد في الدعوى المدنية (دراسة مقارنة)
Authors: داراوك ساهرة موسى 
Published: December 2024

Summary
Renewal in civil litigation Is a legal procedure that has two types within the framework of procedural laws, particularly the civil procedure laws. The first type allows the parties to resume the civil lawsuit before the court after it had been suspended due to the absence of its parties. The second type permits the plaintiff to refile the lawsuit before the court after it has been annulled or considered as if it never existed, due to the parties’ failure to renew the procedures after the prescribed legal time for review or failure to continue the proceedings after renewing them.
In legal systems, the reasons for renewal differ in terms of terminology in Iraqi law compared to comparative legislations, but they do not differ in substance. In Iraqi law, civil lawsuit procedures can be renewed due to the absence of its parties, and this is referred to as "leaving the lawsuit for review." In comparative legislations, this situation is termed as "striking out the lawsuit." As for the reason for renewing the filing of a civil lawsuit, In Iraqi law it is due to its annulment for failure to renew or follow up on the renewal within the legal time limit, whereas comparative legislations use terms like "considering the lawsuit as if it never existed" or "withdrawal of the lawsuit due to annulment" In such cases.
Renewal requires certain mechanisms and conditions that allow the parties to activate its role in both of its types within the framework of civil litigation. It is not permissible at all stages of the lawsuit but can only be applied during specific stages according to the law. Its effects vary depending on its type: the first type, which involves renewing the procedures of the civil lawsuit, restores the lawsuit to its original state by reconvening it between the parties, ensuring the principle of confrontation between the litigants. The second type, which involves renewing the filing of the civil lawsuit, results in the lawsuit being reintroduced before the court through a new petition and procedures, thus bearing the same effects as the initiation of a lawsuit.
Keywords : Renewal ,Leaving the case for review , Annulment of the case.
تطوير النظام المحاسبي للشركات باستخدام الحوسبة السحابية – برنامج Xero أنموذجا
Authors: مجيد احمد وجيه 
Published: December 2024

Abstract
This research has dealt with one of the aspects of the contemporary technological revolution in the field of accounting represented by cloud computing, and how this development can serve accounting, especially the accounting system that determines the output of accounting, and accounting information. The research then attempts to explain the importance of cloud computing and its role in the development of the accounting system for companies. For this purpose, the Xero platform has been selected as it is the best and most well-known platform in respect to the presentation of accounting information based on a number of criteria, including flexibility of use, low cost of data security and information integration. The results of the research have shown that the cloud computing platforms in general and the Xero platform in particular play a major role in the development of corporate accounting systems in terms of safety, low cost, maintenance, flexibility of use, integration and timeliness of information display
Keywords: accounting system, cloud computing , Xero program
Los accidentes de trabajo, enfermedades laborales y sus costos, en el sector de la construcción de la ciudad de San Juan de Pasto
Authors: Villota Ortega Diana Gicela , Garcés Bolaños Nubia Fernanda 
Published: December 2024

El objetivo general se centra en evaluar las implicaciones financieras y sociales de accidentes y enfermedades laborales del sector construcción, en San Juan de Pasto, periodo 2018-2020, para lo cual a nivel metodológio la investigación se inscribe en el paradigma positivista, con un enfoque mixto, bajo una investigación descriptiva. La población objeto de estudio es finita y está conformada por las 27 empresas pertenecientes al sector de la construcción de viviendas, afiliadas a CAMACOL, regional Nariño; a 31 de julio de 2020; no se calcula muestra teniendo en cuenta que la población es finita y pequeña, por tanto, se trabaja como censo. Dentro del sector de la construcción en la ciudad de San Juan de Pasto, periodo 2018, 2019 y 2020 la actividad de mayor peligro y en la que se han materializado el mayor número de enfermedades laborales, accidentes de trabajo, indemnizaciones por incapacidad parcial permanente y pensiones por invalidez es la actividad que incluye solo a construcción de calles, ferrocarriles, casas, caminos, edificios, oleoductos y presas que hace referencia a la Construcción de edificaciones para uso residencial, clasificada dentro del riesgo 5.
Prototipo de carro de mercado de conducción asistida, como solución en la carga y desplazamiento de mercado (alimentos y abarrotes) para personas en condición de discapacidad y adulto mayor con movilidad reducida
Authors: Iregui Cruz Jonnathan , Valbuena Montoya Diego Hernán 
Published: December 2024

Este documento se enfoca en prototipar un Carro de Mercado de Conducción Asistida para personas con movilidad reducida y adultos mayores, como solución a las limitantes físicas y locativas a las que se enfrenta esta población al cargar y desplazar la compra de víveres y abarrotes desde el punto de abastecimiento hasta su hogar. Este objetivo es desarrollado y estimado a partir de una investigación aplicada con enfoque triangular, en la cual se exploraron fuentes de información documental y de campo que cubrió una muestra representativa de 383 personas, con parámetros estadísticos del 95% para el nivel de confianza y de 5% de margen de error. En esa línea, se construye un ejercicio de inteligencia de negocios el cual identificó la pertinencia y necesidad del producto para el segmento de clientes; así como las características mecánicas, niveles de usabilidad y medio de desempeño que buscan lo usuarios. De esta manera, se integran los componentes electrónicos y mecánicos, interfaces de conectividad y los principios ergonómicos en un prototipo a escala que facilita el desplazamiento minimizando los esfuerzos físicos aplicados a la movilización de cargas.
Emprendimiento de la mujer rural duitamense una estrategia de vida
Authors: López Márquez Lupe Isabel , Jiménez Orozco Hilda Lucia 
Published: December 2024

Algunas zonas rurales del municipio de Duitama afrontan situaciones problemáticas que limitan su desarrollo socioeconómico. A pesar de ello la mujer campesina desde hace varias décadas ha asumido un papel protagónico en el fomento del emprendimiento como estrategia para fortalecer la economía en estos espacios geográficos. Desde esta perspectiva, el propósito de este estudio es analizar e interpretar el rol de las mujeres de las veredas la Trinidad y San Antonio del municipio de Duitama en el desarrollo actividades agrarias encaminadas a fortalecer su calidad de vida y la de su núcleo familiar. Se trata de una investigación en la cual se privilegia el método cualitativo abordado desde el estudio de caso para llevar a cabo un análisis contextual, de opiniones, argumentos y reflexiones de las mujeres de este contexto, con el fin de comprender cómo su carácter emprendedor ha permitido que emerja una nueva ruralidad. Los resultados del proceso investigativo son concluyentes, pues se evidencia la necesidad de potenciar el desarrollo integral de la mujer rural de tal forma que se constituya en protagonista social para fortalecer el emprendimiento en su comunidad y por ende mitigar su segregación de la sociedad y el Estado.
Influencia de los dispositivos móviles en el desarrollo socioemocional en niños y niñas de 5 y 6 años del colegio ITAL, sede San Nicolás de Bari
Authors: Arteaga Palomo Richard Manuel , Hernandez Correa Dary Luz 
Published: December 2024

El actual artículo surge de la investigación sobre la Influencia que tienen el uso de dispositivos móviles en el desarrollo socioemocional en niños y niñas de 5 y 6 años, debido a que los menores en estas edades están pasando por un proceso de desarrollo de habilidades socioemocionales que pueden estar afectadas de forma negativa o positiva por el uso de dispositivos móviles, dependiendo muchas veces por el tiempo que se les da a estos en entornos escolares y familiares donde se desenvuelven los niños y niñas, es así, que esta investigación tiene por objetivo Analizar la influencia que tiene el uso de dispositivos móviles en el desarrollo socioemocional en niños y niñas de 5 y 6 años, donde se busca reforzar que el acompañamiento de los padres o cuidadores en el entorno del hogar es primordial para que sus hijos aprendan a gestionar sus emociones al acercarse y manipular estos dispositivos móviles, además reforzar el apoyo que tienen las familias en los docentes para conocer a cerca de las problemáticas que ocasionan los acercamientos a temprana edad. La metodología implementada en esta investigación es cualitativa y de tipo investigación-acción involucrando a 8 padres, 8 estudiantes y la docente del colegio ITAL en Lorica Córdoba. Este enfoque permite describir las afectaciones que sufren las emociones de los educandos en los diferentes espacios de exposición, dónde se destaca que los niños y niñas están usando los dispositivos móviles en exceso en el hogar, con poca supervisión del contenido y el uso prolongado el cual ocasiona dependencia que afecta notoriamente sus emociones.
Ingénierie de formation et interculturalité, méthodes et outils pédagogiques, de Christine Bonnot
Authors: Gonzalez Nolwenn 
Published: December 2024

Ce livre est le fruit de 30 années de travail autour de pratiques et de formations axées sur les enjeux interculturels auprès de professionnel·le·s exerçant dans un contexte de diversité ethnoculturelle (travail à l’international avec expatriation, ou encore travail dans son pays d’origine mais avec des collègues d’autres cultures). Il offre des outils concrets afin d’améliorer les interactions interculturelles ou d’élaborer des formations. On peut distinguer deux parties distinctes dans ce livre : d’abord des exercices dans l’objectif de développer certaines réflexions autour des enjeux interculturels, puis des analyses de situations interculturelles afin d’acquérir un autre mode de pensée. Enfin, le lecteur pourra se référer à plusieurs sources bibliographiques.
Occupational physical activity and all‐cause and cardiovascular disease mortality: Results from two longitudinal studies in Switzerland
Authors: Wanner Miriam , Lohse Tina , Braun Julia , Cabaset Sophie , Bopp Matthias , Krause Niklas , Rohrmann Sabine , for the Swiss National Cohort Study Group  
Published: May 2019

AbstractBackgroundResearch regarding the effects of occupational physical activity on health remains inconsistent. We analyzed the association of occupational physical activity with all‐cause and cardiovascular disease (CVD) mortality.MethodsWe analyzed two cohorts with baseline assessments from 1977 to 1993 (“National Research Program 1A” (NRP1A) and “MONItoring of trends and determinants in CArdiovascular disease" [MONICA]) and mortality follow‐up until 2015 using adjusted Cox regression models.ResultsWe included 4396 NRP1A participants (137 793 person‐years of follow‐up, 1541 deaths) and 5780 MONICA participants (135 410 person‐years, 1158 deaths). All‐cause mortality was higher for men in the high compared with the low occupational physical activity category according to NRP1A (hazard ratio [HR] 1.25, 95% confidence intervals [CI] 1.05‐1.50). CVD mortality was higher for men in the moderate compared with the low occupational physical activity category according to MONICA (HR, 1.41; 95% CI, 1.03‐1.91). Results for women were not statistically significant.ConclusionsWe observed higher total and CVD mortality risks in men with higher occupational physical activity but inconsistent results for women and across cohorts.
Continuum of phenotypes in hereditary motor and sensory neuropathy with proximal predominance and Charcot–Marie–Tooth patients with TFG mutation
Authors: Khani Marzieh , Taheri Hanieh , Shamshiri Hosein , Houlden Henry , Efthymiou Stephanie , Alavi Afagh , Nafissi Shahriar , Elahi Elahe 
Published: May 2019

AbstractCharcot–Marie–Tooth (CMT) is a common neuropathy, and hereditary motor and sensory neuropathy with proximal predominance (HMSN‐P) is a recently described rare neuromuscular disease. Although many genes have been implicated for CMT, TFG is the only known HMSN‐P‐causing gene. Within the framework of diagnostic criteria, clinical variation is evident among CMT‐diagnosed and also HMSN‐P‐diagnosed individuals. Mutations that cause p.(Pro285Leu) and p.(Gly269Val) in TFG were earlier reported as cause of HMSN‐P in two Iranian pedigrees. Here, we report the identification of p.(Gly269Val) in TFG as cause of CMT in a large Iranian pedigree. The clinical features of patients of the three pedigrees are presented and critically compared. Similarities between the two HMSN‐P‐diagnosed pedigrees with different TFG mutations, and differences between the two differentially diagnosed pedigrees with the same p.(Gly269Val) mutation were evident. The clinical features of the HMSN‐P pedigree with the p.(Pro285Leu) and the CMT pedigree with the p.(Gly269Val) mutation were clearly congruent with the respective diagnoses, whereas the features of the HMSN‐P‐diagnosed pedigree with the p.(Gly269Val) were intermediate between the other two pedigrees. It is therefore suggested that the clinical features of the three Iranian pedigrees with TFG mutations and diagnosed with HMSN‐P or CMT represent a continuum.
Muenke syndrome: Medical and surgical comorbidities and long‐term management
Authors: Murali Chaya N. , McDonald‐McGinn Donna M. , Wenger Tara Lynn , McDougall Carey , Stroup Bridget M. , Sheppard Sarah E. , Taylor Jesse , Bartlett Scott P. , Bhoj Elizabeth J. , Zackai Elaine H. , Santani Avni 
Published: May 2019

AbstractMuenke syndrome (MIM #602849), the most common syndromic craniosynostosis, results from the recurrent pathogenic p.P250R variant in FGFR3. Affected patients exhibit wide phenotypic variability. Common features include coronal craniosynostosis, hearing loss, carpal and tarsal anomalies, and developmental/behavioral issues. Our study examined the phenotypic findings, medical management, and surgical outcomes in a cohort of 26 probands with Muenke syndrome identified at the Children's Hospital of Philadelphia. All probands had craniosynostosis; 69.7% had bicoronal synostosis only, or bicoronal and additional suture synostosis. Three male patients had autism spectrum disorder. Recurrent ear infections were the most common comorbidity, and myringotomy tube placement the most common extracranial surgical procedure. Most patients (76%) required only one fronto‐orbital advancement. de novo mutations were confirmed in 33% of the families in which proband and both parents were genetically tested, while in the remaining 66% one of the parents was a mutation carrier. In affected parents, 40% had craniosynostosis, including 71% of mothers and 13% of fathers. We additionally analyzed the medical resource utilization of probands with Muenke syndrome. To our knowledge, these data represent the first comprehensive examination of long‐term management in a large cohort of patients with Muenke syndrome. Our study adds valuable information regarding neuropsychiatric and medical comorbidities, and highlights findings in affected relatives.
Depolymerization of End‐of‐Life Poly(bisphenol A carbonate) via Alkali‐Metal‐Halide‐Catalyzed Methanolysis
Authors: Alberti Christoph , Enthaler Stephan 
Published: May 2019

AbstractChemical recycling, composed of depolymerization and polymerization, of end‐of‐life polymers (plastics) can contribute to a sustainable and resource‐conserving society. In this respect, we have installed a straightforward procedure for the first step (depolymerization) of the chemical recycling of end‐of‐life poly(bisphenol A carbonate). Operating with a combination of methanol and catalytic amounts of potassium fluoride end‐of‐life poly(bisphenol A carbonate) was depolymerized to the building blocks bisphenol A and dimethyl carbonate. With the assistance of microwave heating, an excellent rate of depolymerization (>99%) was observed within short reaction times (5 min) and turnover frequencies up to ∼1844 h−1 were realized. Noteworthly, bisphenol A and dimethyl carbonate could be applied as monomers for new poly(bisphenol A carbonate), therefore a closed cycle for poly(bisphenol A carbonate) is feasible.
Synthesis of 3‐Bromoindenes from 4‐Alkynyl Alcohols/Sulfonamides and Aldehydes via Prins Cyclization, Ring‐Opening and Friedel‐Crafts Reactions
Authors: Kotipalli Trimurtulu , Hou Duen‐Ren 
Published: May 2019

AbstractA one‐pot, two‐staged protocol has been developed for the synthesis of 3‐bromoindenes from aryl alkynyl alcohols/sulfonamides and aldehydes. Bromotrimethylsilane (TMSBr) initiated a halo‐Prins cyclization reaction to give 3‐(bromomethylene)‐tetrahydropyrans or ‐piperidines, which underwent ring‐opening and Friedel‐Crafts allylation to yield 3‐bromoindenes in the presence of Brønsted acids.
Direct Monitoring of Cell Membrane Vesiculation with 2D AuNP@MnO2 Nanosheet Supraparticles at the Single‐Particle Level
Authors: Ling Yunyun , Zhang Di , Cui Ximin , Wei Meimei , Zhang Ting , Wang Jianfang , Xiao Lehui , Xia Yunsheng 
Published: May 2019

AbstractWe herein demonstrate robust two‐dimensional (2D) UFO‐shaped plasmonic supraparticles made of gold nanoparticles (AuNPs) and MnO2 nanosheets (denoted as AMNS‐SPs) for directly monitoring cell membrane vesiculation at the single‐particle level. Because the decorated MnO2 nanosheets are ultrathin (4.2 nm) and have large diameters (230 nm), they are flexible enough for deformation and folding for parceling of the AuNPs during the endocytosis process. Correspondingly, the surrounding refractive index of the AuNPs increases dramatically, which results in a distinct red‐shift of the localized surface plasmon resonance (LSPR). Such LSPR modulation provides a convenient and accurate means for directly monitoring the dynamic interactions between 2D nanomaterials and cell membranes. Furthermore, for the endocytosed AMNS‐SPs, the subsequent LSPR blue‐shift induced by etching effects of reducing molecules is promising for exploring the local environment redox states at the single‐cell level.
An Antimony(V) Dication as a Z‐Type Ligand: Turning on Styrene Activation at Gold
Authors: Lo Ying‐Hao , Gabbaï François P. 
Published: May 2019

AbstractWith the intent to demonstrate that the charge of Z‐type ligands can be used to modulate the electrophilic character and catalytic properties of coordinated transition metals, we are now targeting complexes bearing polycationic antimony‐based Z‐type ligands. Toward this end, the dangling phosphine arm of ((o‐(Ph2P)C6H4)3)SbCl2AuCl (1) was oxidized with hydrogen peroxide to afford [((o‐(Ph2P)C6H4)2(o‐Ph2PO)C6H4)SbAuCl2]+ ([2 a]+) which was readily converted into the dicationic complex [((o‐(Ph2P)C6H4)2(o‐Ph2PO)C6H4)SbAuCl]2+ ([3]2+) by treatment with 2 equiv AgNTf2. Both experimental and computational results show that [3]2+ possess a strong Au→Sb interaction reinforced by the dicationic character of the antimony center. The gold‐bound chloride anion of [3]2+ is rather inert and necessitates the addition of excess AgNTf2 to undergo activation. The activated complex, referred to as [4]2+ [((o‐(Ph2P)C6H4)2(o‐Ph2PO)C6H4)SbAuNTf2]2+ readily catalyzes both the polymerization and the hydroamination of styrene. This atypical reactivity underscores the strong σ‐accepting properties of the dicationic antimony ligand and its activating impact on the gold center.