bluuebunny/crossref_metadata_2025_split huggingface dataset:
Secondary Ice Production by Fragmentation of Freezing Drops: Formulation and Theory
Authors: Phillips Vaughan T. J. , Patade Sachin , Gutierrez Julie , Bansemer Aaron 
Published: June 2018

Abstract
A numerical formulation is provided for secondary ice production during fragmentation of freezing raindrops or drizzle. This is obtained by pooling laboratory observations from published studies and considering the physics of collisions. There are two modes of the scheme: fragmentation during spherical drop freezing (mode 1) and during collisions of supercooled raindrops with more massive ice (mode 2). The empirical scheme is for atmospheric models. Microphysical simulations with a parcel model of fast ascent (8 m s−1) between −10° and −20°C are validated against aircraft observations of tropical maritime deep convection. Ice enhancement by an order of magnitude is predicted from inclusion of raindrop-freezing fragmentation, as observed. The Hallett–Mossop (HM) process was active too. Both secondary ice mechanisms (HM and raindrop freezing) are accelerated by a positive feedback involving collisional raindrop freezing. An energy-based theory is proposed explaining the laboratory observations of mode 1, both of approximate proportionality between drop size and fragment numbers and of their thermal peak. To illustrate the behavior of the scheme in both modes, the glaciation of idealized monodisperse populations of drops is elucidated with an analytical zero-dimensional (0D) theory treating the freezing in drop–ice collisions by a positive feedback of fragmentation. When drops are too few or too small (≪1 mm), especially at temperatures far from −15°C (mode 1), there is little raindrop-freezing fragmentation on realistic time scales of natural clouds, but otherwise, high ice enhancement (IE) ratios of up to 100–1000 are possible. Theoretical formulas for the glaciation time of such drop populations, and their maximum and initial growth rates of IE ratio, are proposed.
Time Evolution of Estuarine Turbidity Maxima in Well-Mixed, Tidally Dominated Estuaries: The Role of Availability- and Erosion-Limited Conditions
Authors: Brouwer Ronald L. , Schramkowski George P. , Dijkstra Yoeri M. , Schuttelaars Henk M. 
Published: June 2018

AbstractUsing an idealized width-averaged process-based model, the role of a mud pool on the bed and time-varying river discharge on the trapping of fine sediment is systematically investigated. For this purpose, a dynamically and physically motivated description of erodibility is presented, which relates the amount of sediment on the bed to the suspended sediment concentration (SSC). We can distinguish between two states: in the availability-limited state, the SSC is limited by the amount of erodible sediment at the bed. Over time, under constant forcing conditions, the estuary evolves to morphodynamic equilibrium. In the erosion-limited state, there is an abundant amount of sediment at the bed so that sediment pickup occurs at the maximum possible rate. The SSC is then limited by the local hydrodynamic conditions. In this state, the estuary keeps importing sediment, forming an erodible bottom pool that grows in time. These two states can be used to explain the response of an estuary to changing river discharge. Under availability-limited conditions, periods of high river discharge push estuarine turbidity maxima (ETMs) downstream, while drier periods allow ETMs to move upstream. However, when the estuary is in an erosion-limited state during low river discharge, a bottom pool is formed. When the discharge then increases, it takes time to deplete this pool, so that an ETM located over a bottom pool moves with a significant time lag relative to changes in the river discharge. Good qualitative agreement is found between model results and observations in the Scheldt Estuary of surface SSC using a representative year of discharge conditions.
Central Asia
Authors: Patnaik Ajay 
Published: June 2018

The newly independent countries of Central Asia were eager to integrate their economies with the global economy. This required not only the dismantling of the state-controlled economy but also ushering in some form of democracy, free press and independent civil society. Beginning with 1991, the leadership in Central Asia tried to shed the tag of being Communist Party leaders and sought political legitimacy on the basis of nationalism and democracy. As a result, the initial years following independence saw some progress away from the Soviet political system. But later this trend weakened and most states moved to a more authoritarian system. Some scholars argue that this is due to the enduring Soviet political culture. This could be so; but after nearly 26 years, everything cannot be attributed to Soviet legacy. This article argues that Central Asian states are strongly influenced by the current developments within and outside. The continuation of authoritarianism has been possible because of popular support for the leader as a symbol of stability. However, there are factors that could change popular perception and shake the edifice of the current system.
Utility of the Surgical Apgar Score in Head and Neck Squamous Cell Carcinoma
Authors: Prince Andrew C. , Day Kristine E. , Lin Chee Paul , Greene Benjamin J. , Carroll William R. 
Published: June 2018

ObjectivesTo recognize the utility of the surgical Apgar score (SAS) in a noncutaneous head and neck squamous cell carcinoma (HNSCC) population.Study DesignRetrospective case series with chart review.SettingAcademic tertiary medical center.Subjects and MethodsPatients (n = 563) undergoing noncutaneous HNSCC resection between April 2012 and March 2015 were included. Demographics, medical history, intraoperative data, and postoperative hospital summaries were collected. SASs were calculated following the published schema. The primary outcome was 30‐day postoperative morbidity. A 2‐sample t test, analysis of variance, and χ2 (or Fisher exact) test were used for statistical comparisons. A multivariable logistic regression analysis was conducted to identify independent predictors of 30‐day morbidity.ResultsMean SAS was 6.2 ± 1.5. SAS groups did not differ in age, sex, or race. Sixty‐five patients (11.6%) had a SAS between 0 and 4, with 40 incidences of morbidity (61.5%), while 31 (5.5%) patients with SAS from 9 to 10 had 3 morbidity occurrences (9.7%). Results show that 30‐day postoperative morbidity is inversely related to increasing SAS (P <. 0001). Furthermore, lower SAS was associated with significantly increased operative time (SAS 0‐4: 9.3 ± 2.6 hours vs SAS 9‐10: 3.0 ± 1.1 hours) and lengths of stay (SAS 0‐4: 10.0 ± 7.3 days vs SAS 9‐10: 1.6 ± 1.0 days), P <. 0001. SAS remained highly significant after adjusting for potential confounding variables in the multivariable analysis (P <. 0001).ConclusionsAn increasing SAS is associated with significantly lower rates of 30‐day postoperative morbidities in a noncutaneous HNSCC patient population.
Risk factors for recurrence of common bile duct stones after endoscopic biliary sphincterotomy
Authors: Li Sujuan , Su Bingzhong , Chen Ping , Hao Jianyu 
Published: June 2018

Objective Late complications after endoscopic biliary sphincterotomy (EST) include stone recurrence, but no definite risk factors for recurrence have been established. This study was performed to identify the predictors of recurrence and evaluate the clinical outcomes of EST for common bile duct stones. Methods In total, 345 eligible patients who successfully underwent EST were evaluated and followed up. Statistical analysis was performed on patients with recurrence or who had undergone at least 6 months of reliable follow-up to detect the risk factors for recurrence. Results A total of 57 patients (16.52%) developed recurrence of common bile duct stones. The median length of time until recurrence was 10.25 months (range, 6–54.4 months). Univariate analyses showed that the following factors were associated with recurrence: cholecystectomy prior to EST, prior biliary tract surgery, periampullary diverticulum, diameter of the common bile duct (>15 vs. ≤15 mm), quantity of stones, complete stone removal at the first session, and lithotripsy. Multivariate analysis identified two independent risk factors for recurrence: previous biliary tract surgery and lithotripsy. Conclusions EST for common bile duct stones is safe as indicated by patients’ long-term outcomes. Patients with a history of biliary surgery or lithotripsy are more prone to recurrence.
Prognostic impact of miR-196a/b expression in adult acute myeloid leukaemia: a single-centre, retrospective cohort study
Authors: Zhang JunYu , Liu WeiE , Du Jing , Jin YangJin , Zhao MinLei , Li LinJie , Wang Ying 
Published: June 2018

Objective The prognostic effect of miR-196a/b expression in adult patients with leukaemia remains unclear. This study aimed to determine whether miR-196a/b expression can serve as a prognostic factor for patients with acute myeloid leukaemia. Methods We enrolled 124 patients with acute myeloid leukaemia. We measured miR-196a/b expression by real-time reverse transcription-polymerase chain reaction. We classified patients into high and low expression groups based on the median expression value. Cox regression analyses were carried out to assess the prognostic significance of miR-196a/b expression in the context of well-established predictors. Results Patients with high miR-196a/b expression were older in age, and had higher white blood cell and platelet counts than did patients with low miR-196a/b expression. Patients with high miR-196a/b expression were associated with the French–American–British classification M5 subtype and with the presence of nucleophosmin and FLT3 internal tandem duplication mutations, but were not associated with the favourable karyotype risk subgroup. Moreover, patients with high miR-196a/b expression had a shorter event-free survival rate compared with those with low miR-196a/b expression in univariate and multivariate analyses. Conclusion High miR-196a/b expression is associated with poor event-free survival.
Harms of Antipsychotics in Children and Young Adults: A Systematic Review Update
Authors: Pillay Jennifer , Boylan Khrista , Newton Amanda , Hartling Lisa , Vandermeer Ben , Nuspl Megan , MacGregor Tara , Featherstone Robin , Carrey Normand 
Published: June 2018

Objective: To update and extend our previous systematic review on first- (FGAs) and second-generation antipsychotics (SGAs) for treatment of psychiatric and behavioral conditions in children, adolescents, and young adults (aged ≤24 years). This article focuses on the evidence for harms. Method: We searched (to April 2016) 8 databases, gray literature, trial registries, Food and Drug Administration reports, and reference lists. Two reviewers conducted study screening and selection independently, with consensus for selection. One reviewer extracted and another verified all data; 2 reviewers independently assessed risk of bias. We conducted meta-analyses when appropriate and network meta-analysis across conditions for changes in body composition. Two reviewers reached consensus for ratings on the strength of evidence for prespecified outcomes. Results: A total of 135 studies (95 trials and 40 observational) were included, and 126 reported on harms. FGAs caused slightly less weight gain and more extrapyramidal symptoms than SGAs. SGAs as a class caused adverse effects, including weight gain, high triglyceride levels, extrapyramidal symptoms, sedation, and somnolence. They appeared to increase the risk for high cholesterol levels and type 2 diabetes. Many outcomes for individual drug comparisons were of low or insufficient strength of evidence. Olanzapine caused more short-term gains in weight and body mass index than several other SGAs. The dose of SGAs may not make a difference over the short term for some outcomes. Conclusions: Clinicians need to weigh carefully the benefit-to-harm ratio when using antipsychotics, especially when treatment alternatives exist. More evidence is needed on the comparative harms between antipsychotics over the longer term.
Estimation of Atenolol Transfer Into Milk and Infant Exposure During Its Use in Lactating Women
Authors: Lwin Ei Mon Phyo , Gerber Cobus , Leggett Catherine , Song Yunmei , Ritchie Usha , Turner Sean , Hague William , Upton Richard , Garg Sanjay 
Published: June 2018

Background: Atenolol lactation information is limited, and controversy exists over the safety of its use during breastfeeding. In this study, important parameters including milk-to-plasma ratio, ratio of infant plasma to maternal plasma, infant daily dosage, and relative infant dose were investigated. The findings from this study add information to existing data about atenolol transfer in human milk. This may help guide health professionals in decision making regarding the safety of beta blockers used by mothers during breastfeeding. Research aim: The aims of the study were to quantify concentrations of atenolol in human plasma and milk, to evaluate atenolol pharmacokinetics in lactating women, and to investigate subsequent infant exposure to atenolol via mother’s milk. Methods: In this prospective, longitudinal observational study, participants were lactating mothers ( N = 3), 1 to 4 months postpartum, who had been taking atenolol for therapeutic reasons, and one 4-month-old breastfed infant. Eight milk samples were collected over 24 hr at different time points, together with a single blood sample from each lactating mother and the infant, and quantified using a new sensitive liquid chromatography mass spectrometry method developed for this study. Results: Peak milk concentrations of atenolol were observed in the women at 4 hr (Tmax) after oral administration. The dose-normalized maximum concentrations (Cmax) of all patients were similar. The mean milk-to-plasma ratio of the patients who were taking 25 to 100 mg of atenolol was 8.57%. In the mother–infant pair study, the ratio (%) of infant plasma drug concentration to maternal plasma drug concentration observed (18.87%) was similar to the relative infant dose estimated (18.20%). The relative infant dose values (13.96%-18.20%) for all patients were within 10% to 25% of maternal dosage. Conclusion: Atenolol use during breastfeeding should be undertaken with some precaution. If clinically indicated, an alternate beta blocker may be preferred.
Evaluation of oxidative stress in pseudo-exfoliative glaucoma patients treated with and without topical coenzyme Q10 and vitamin E
Authors: Ozates Serdar , Elgin Kadriye Ufuk , Yilmaz Niyazi Samet , Demirel Ozlem Ozbas , Sen Emine , Yilmazbas Pelin 
Published: June 2018

Purpose: To evaluate the levels of oxidative stress markers such as superoxide dismutase and malondialdehyde in eyes with pseudo-exfoliative glaucoma treated with and without topical coenzyme Q10 (CQ10) and vitamin E (Coqun drop). Methods: This prospective, randomized clinical study was conducted on 64 eyes of 64 patients. All patients underwent phacoemulsification and intraocular lens implantation surgery. Aqueous humor samples were aspirated from the anterior chamber at the beginning of cataract surgery. The pseudo-exfoliative glaucoma + Coqun group received topical Coqun (100 mg CQ10, 500 mg Vitamin E TPGS) twice daily for 1 month preoperatively, while the pseudo-exfoliative glaucoma group consisted of pseudo-exfoliative glaucoma cases who had not taken Coqun. Pseudo-exfoliation syndrome cases formed the pseudo-exfoliation syndrome group. The main outcomes were the superoxide dismutase and malondialdehyde levels of aqueous humor in both groups. Results: The mean aqueous humor superoxide dismutase level was significantly higher in the pseudo-exfoliative glaucoma group than in pseudo-exfoliative glaucoma + Coqun and pseudo-exfoliation syndrome groups (p < 0.001, p = 0.004, respectively). Also, the mean aqueous humor superoxide dismutase level was significantly lower in the pseudo-exfoliation syndrome group than in pseudo-exfoliative glaucoma + Coqun group (p = 0.009). The mean malondialdehyde levels showed no significant difference between the groups (p > 0.05 for all). Conclusion: Our study showed lower aqueous humor level of superoxide dismutase in pseudo-exfoliation syndrome patients compared to pseudo-exfoliative glaucoma patients. Significantly lower superoxide dismutase level was observed in pseudo-exfoliative glaucoma patients who received topical Coqun compared to pseudo-exfoliative glaucoma patients without Coqun treatment. No significant change was observed on the malondialdehyde level during 1-month follow-up period.
Noninvasive ventilation and respiratory physical therapy reduce exercise-induced bronchospasm and pulmonary inflammation in children with asthma: randomized clinical trial
Authors: David Maisi Muniz Cabral , Gomes Evelim Leal de Freitas Dantas , Mello Maryjose Carvalho , Costa Dirceu 
Published: June 2018

Background: Asthma is characterized by hyperresponsiveness of the airways, and exercise-induced bronchospasm (EIB) is a symptom that limits a large proportion of asthmatic patients, especially children. Continuous positive airway pressure (CPAP) leads to a reduction in the reactivity of the airways. The aim of this study was to evaluate the effect of outpatient treatment with CPAP and bilevel pressure combined with respiratory physical therapy for children and adolescents with asthma following bronchial hyperresponsiveness caused by an exercise bronchoprovocation test. Methods: A randomized, controlled, blind, clinical trial was conducted involving 68 asthmatic children and adolescents aged 4 to 16 years divided into three groups: G1, treated with bilevel pressure (inspiratory positive airway pressure: 12 cm H2O; expiratory positive airway pressure: 8 cm H2O), G2, treated with CPAP (8 cm H2O) and G3, treated with respiratory muscle training (RMT), considered as the control group. All groups were treated at an outpatient clinic and submitted to 10 1-hour sessions, each of which also included respiratory exercises. Evaluations were performed before and after treatment and involved spirometry, an exercise bronchoprovocation test, respiratory pressures, fraction of nitric oxide (FeNO), the Asthma Control Questionnaire (ACQ6) and anthropometric variables. This study received approval from the local ethics committee (certificate number: 1487225/2016) and is registered with ClinicalTrials [ ClinicalTrials.gov identifier: NCT02939625]. Results: A total of 64 patients concluded the protocol; the mean age of the patients was 10 years. All were in the ideal weight range and had adequate height ( z score: −2 to +2). The three groups demonstrated improved asthma control after the treatments, going from partial to complete control. A significant increase in maximal inspiratory pressure occurred in the three groups, with the greatest increase in the RMT group. A reduction in FeNO in the order of 17.4 parts per billion (effect size: 2.43) and a reduction in bronchial responsiveness on the exercise bronchoprovocation test occurred in the bilevel group. An improvement in FeNO on the order of 15.7 parts per billion (effect size: 2.46) and a reduction in bronchial responsiveness occurred in the CPAP group. No changes in lung function or responsiveness occurred in the RMT group. Conclusion: Positive pressure and respiratory exercises were effective in reducing pulmonary inflammation, exercise-innduced bronchoespasm (EIB), and increased the clinical control of asthma, as well as RMT, which also resulted in improved clinical control.
Health promotion policies in the Republic of Korea and Japan: A comparative study
Authors: Nam Eun Woo , Hasegawa Toshihiko , Davies John Kenneth , Ikeda Nayu 
Published: June 2018

Health promotion strategies have been developed and implemented in some Asian countries, particularly in the Republic of Korea (Korea) and Japan. It would help to understand features of health promotion in each country to compare health promotion strategies between them. In this study, using categories developed by HP-Source.net, we conducted a comparative analysis of health promotion strategies between Korea and Japan to understand features of health promotion in each country and contribute to the improvement of population health. One of the goals of Health Plan 2010 is to assess its achievements with numerical targets, which is also the case in Japan. One of the important discussion points involves a decision on the optimal number of targets for evaluation. There is a major difference in the funding of health promotion activities between Korea and Japan. They are financed through the general account in Japan, while in Korea a foundation for health promotion has been established and the income from tobacco tax is ring-fenced for this fund. The database and methodology of HP-Source needs adaptation for global use. We encountered some disadvantages in using its current framework for comparing and analysing information on health promotion in Korea and Japan. It has been recognised that HP-Source could influence the development and implementation of health promotion strategies in other parts of the world. Health promotion tools can help decision makers, planners and researchers to formulate and enhance comprehensive plans. In this study we learned many lessons in expanding policy tools outside of one region to aid the global development of effective health promotion policy and practice.
The use of emerging technology to build health promotion capacity in regions with diversity in language and culture
Authors: Perry Martha W. , Mittelmark Maurice B. 
Published: June 2018

Today in the human development arena, three actors play complementary, sometimes competing, and even conflicting roles on the world stage: governments, commercial enterprises and non-governmental organisations. Given their mission and available resources, each of these interact in different ways between each other, but have the same basis and needs for communication among each other. Two of the factors that come into play in these actors’ operations are technology and internationalisation. We currently live the digital era brought on by the technological revolution. This has provided international actors with speed and flexibility over traditional communication formats to disseminate their work and collaborate more closely in real time and across geographical, cultural and language barriers. In order to be efficient and effective, these actors have begun and must continue to engage in this global transformation. All this is relevant to the IUHPE as a global organisation with members in over 90 countries. The hundreds of cultures and languages of our members enrich our ability to advocate for health in every corner of the world. However, our diversity can hinder our effectiveness. Language barriers separating even neighbours can make collaborative work difficult. There are several solutions that the IUHPE is adopting to bridge this divide, among them, using Information and Communication Technology (ICT). Within this context, this paper examines the different multi-dimensional dialogue and information platforms offered by ICTs today and its future developments. This will include advantages and limitations with regard to both technological and financial nuances. The use of technology will be defined in relation to the implications for knowledge acquisition, conversation and action. The scenarios include the web as a global resource database and ICTs, including machine translation, for one-on-one and multi-party communication. In a world that is increasingly entwined across borders, technology provides organisations with the opportunity to communicate more efficiently and effectively than at any time in history. By adopting new ICTs the IUHPE places itself on the avantguard of internal and external communications and in comparative advantage to influence the other two major global actors.