bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Paf1 Complex Broadly Impacts the Transcriptome ofSaccharomyces cerevisiae
Authors: Ellison Mitchell A , Lederer Alex R , Warner Marcie H , Mavrich Travis N , Raupach Elizabeth A , Heisler Lawrence E , Nislow Corey , Lee Miler T , Arndt Karen M 
Published: May 2019

AbstractThe Polymerase Associated Factor 1 complex (Paf1C) is a multifunctional regulator of eukaryotic gene expression important for the coordination of transcription with chromatin modification and post-transcriptional processes. In this study, we investigated the extent to which the functions of Paf1C combine to regulate the Saccharomyces cerevisiae transcriptome. While previous studies focused on the roles of Paf1C in controlling mRNA levels, here, we took advantage of a genetic background that enriches for unstable transcripts, and demonstrate that deletion of PAF1 affects all classes of Pol II transcripts including multiple classes of noncoding RNAs (ncRNAs). By conducting a de novo differential expression analysis independent of gene annotations, we found that Paf1 positively and negatively regulates antisense transcription at multiple loci. Comparisons with nascent transcript data revealed that many, but not all, changes in RNA levels detected by our analysis are due to changes in transcription instead of post-transcriptional events. To investigate the mechanisms by which Paf1 regulates protein-coding genes, we focused on genes involved in iron and phosphate homeostasis, which were differentially affected by PAF1 deletion. Our results indicate that Paf1 stimulates phosphate gene expression through a mechanism that is independent of any individual Paf1C-dependent histone modification. In contrast, the inhibition of iron gene expression by Paf1 correlates with a defect in H3 K36 trimethylation. Finally, we showed that one iron regulon gene, FET4, is coordinately controlled by Paf1 and transcription of upstream noncoding DNA. Together, these data identify roles for Paf1C in controlling both coding and noncoding regions of the yeast genome.
Sistemas narrativos historiográficos: La realidad de la ficción en Pedro Bohórquez, el Inca del Tucumán
Authors: Lavagnino Nicolás 
Published: May 2019

El presente artículo atiende dos preguntas interrelacionadas. Por un lado, se interroga por el estatuto de la ficción, incluyendo entre sus modalidades a la narración. Por otro lado, se enfoca la especificidad de la operación historiográfica y su vinculación con las modalidades ficcionales. Para ello se avanza en el entrecruzamiento de la filosofía narrativista de la historia y de la teoría de sistemas, considerando para ello a autores clave como Hayden White y Niklas Luhmann. Finalmente, se abordará una narrativa en particular, la obra de Teresa Piossek Prebisch, Pedro Bohórquez, el Inca del Tucumán, lo cual permitirá observar este cruce teórico en funcionamiento. Y, a la vez, poner en perspectiva apropiadamente el problema, rasgos y alcance del recurso ficcional en el marco de lo que aquí se denomina sistemas narrativos historiográficos.
Safe Opioid Use, Storage, and Disposal Strategies in Cancer Pain Management
Authors: Reddy Akhila , de la Cruz Maxine 
Published: May 2019

Abstract

Opioids are required by a majority of patients with advanced cancer. Oncologists and palliative care clinicians are faced with the challenge of safely prescribing opioids in the current environment of an opioid crisis. Many patients with cancer use opioids unsafely, store them in unsecure locations, and do not dispose of unused opioids, leading to increased availability of these opioids for others to misuse. More than 50% of people who misuse opioids obtain the drugs from a friend or relative with or without their consent. Patient and provider education has been shown to improve safe opioid use, promote secure storage, and also increase disposal of unused opioids safely in drug take-back programs that are now widely available. This article highlights the importance of patient education and cautious opioid prescribing in patients with cancer.

Implications for Practice
The current opioid crisis makes it challenging to effectively manage cancer pain. Providers play a prominent role in minimizing opioid misuse. Cautious prescribing with limits enforced on the quantity of opioids prescribed, close follow-up, and consistent and frequent provision of opioid education are a must. Evidence points to the impact of patient education in promoting safety around opioid use. Most people who misuse prescription opioids obtain them from family or friends. Storing opioids in the open or not disposing of unused opioids increases the availability of these opioids for misuse by others. The importance of not sharing, always locking up, and disposing of unused and expired opioids must be highlighted as part of the opioid education that must be delivered every time that opioids are prescribed. Information about local drug take-back programs may also help increase disposal of unused opioids.
The Primary-Secondary Care Partnership to Improve Outcomes in Chronic Kidney Disease (PSP-CKD) Study: A Cluster Randomized Trial in Primary Care
Authors: Major Rupert W. , Brown Celia , Shepherd David , Rogers Stephen , Pickering Warren , Warwick Graham L. , Barber Shaun , Ashra Nuzhat B. , Morris Tom , Brunskill Nigel J. 
Published: May 2019

Significance Statement
Although most patients with CKD are managed in the primary care setting, the evidence base for CKD care in general practice is scant, and it is not clear whether specific CKD management programs can alter outcomes in primary care. The authors conducted a cluster randomized, controlled trial comparing 23 primary care practices offering usual care with 23 primary care practices in which a nurse practitioner helped those practices interpret patient data files and implement guideline-based CKD interventions. They found that the intervention did not affect rate of eGFR decline, but it did lead to significant improvements in processes, quality of care, and the number of patients achieving BP targets. This approach may improve processes of care, potentially reducing the burden of cardiovascular disease in patients with CKD.

Background
Most patients with CKD are managed in the community. Whether nurse-led CKD management programs improve outcomes in patients with CKD in primary care is unclear.

Methods
To assess the effect of such a program on the rate of renal function decline in patients with CKD (stages 3–5) in primary care in the United Kingdom, we conducted a cluster randomized trial, the Primary-Secondary Care Partnership to Improve Outcomes in Chronic Kidney Disease study. A software program designed for the study created a data file of patients with CKD in participating practices. In 23 intervention practices (11,651 patients), a CKD nurse practitioner worked with nominated practice leads to interpret the data file and implement guideline-based patient-level CKD management interventions. The 23 control practices (11,706 patients) received a data file but otherwise, continued usual CKD care. The primary outcome was defined at the cluster (practice) level as the change from baseline of the mean eGFR of the patients with CKD at 6-month intervals up to 42 months. Secondary outcomes included numbers of patients coded for CKD, mean BP, numbers of patients achieving National Institute for Health and Care Excellence BP targets for CKD, and proteinuria measurement.

Results
After 42 months, eGFR did not differ significantly between control and intervention groups. CKD- and proteinuria-related coding improved significantly along with the number of patients achieving BP targets in the intervention group versus usual care.

Conclusions
CKD management programs in primary care may not slow progression of CKD, but they may significantly improve processes of care and potentially decrease the cardiovascular disease burden in CKD and related costs.
PEDAGOGIK LITERASI KRITIS ; SEJARAH, FILSAFAT DAN PERKEMBANGANNYA DI DUNIA PENDIDIKAN
Authors: Hendriani Ani 
Published: May 2019

Makalah ini bertujuan untuk menganalisis konsep pedagogik literasi kritis, mulai dari sejarah, pemikiran para filsuf, dan perkembangannya di dunia pendidikan dewasa ini. Penelitian ini dilatarbelakangi oleh masih jarangnya pembahasan literasi sebagai kekuatan pengubah struktur sosial, pendidikan literasi kritis dapat membantu siswa untuk menandai dan mengurai beragam teks yang merepresentasikan marjinalisasi sosial, penyalahgunaan kekuasaan, ketidakadilan, penindasan, isu ras, isu gender, dan beragam kesenjangan sosial lainnya. Pendidikan literasi kritis akan membantu siswa menjadi agensi untuk mengubah realitas sosial yang kurang memihak. Metode penelitian yang digunakan adalah analisis konsep dengan desain analisis generik (McMillan & Schumacher, 2001) atau integrative review (Whittemore and Knafl 2005). Hasil dari penelitian menunjukkan bahwa sejarah literasi kritis dimulai dari pemikiran Paulo Freire, seorang pedagog dari Brazil yang banyak membawa perubahan di dunia pendidikan melalui pemikirannya tentang konsep literasi sebagai aktivitas membaca kata dan dunia, literasi kritis juga dianggap sebagai kekuatan sosial (Gramsci), perjuangan emansipasi wanita (Ajayi), Agensi dan pemecahan masalah sosial (Hendriani dkk). Penelitian ini memiliki signifikansi untuk memperkaya khazanah pedagogik pada umumnya, khususnya pedagogik kritis pada lingkup pendidikan literasi. Implikasi dari penelitian ini adalah untuk pengembangan pendidikan berbasis literasi kritis pada jenjang pendidikan dasar sampai pendidikan tinggi. This paper aims to analyze the concept of critical literacy pedagogy, from history, philosophers' thinking, and its development in the world of education today. This research is motivated by the rarely discussed literacy as a power to change social structure, critical literacy education can help students to mark and parse various texts representing social marginalization, abuse of power, injustice, oppression, racial issues, gender issues, and various other social inequalities. Critical literacy education will help students become an agency to change the impartiality of social reality. The research method used is concept analysis with generic analysis design (McMillan & Schumacher, 2001) or integrative review (Whittemore and Knafl 2005). The results of the research indicate that the history of critical literacy begins with the thought of Paulo Freire, a Brazilian pedagogue who brought much change in the world of education through his thoughts on the concept of literacy as the activity of reading the word and the world, critical literacy also regarded as social forces (Gramsci), the struggle for emancipation women (Ajayi), Agency and social problem solving (Hendriani et al). This study has significance to enrich the pedagogic treasures in general, especially critical pedagogy on the scope of literacy education. The implications of this research are for the development of critical literacy-based education at the elementary to higher education level.
Lercaro y el principio de la arquitectura moderna al servicio de la liturgia
Authors: Gresleri Glauco 
Published: May 2019

Lo que voy a relatar en este foro tan acreditado, será la historia de un obispo de la ciudad de Bolonia con sabor a leyenda y que, en el transcurso de dieciséis años del siglo XX, a lomos de su cabalgadura, se ha batido en una serie de victoriosas batallas que terminaron, al final, en una derrota épica. El personaje que está en el centro de este acontecimiento es un sacerdote, de nombre Giacomo, hijo de Giuseppe Lercaro y de Aurelia Picasso, nacido frente al mar de Génova el 28 de octubre de 1891, ordenado sacerdote en 1914 y nombrado por el Sumo Pontífice, arzobispo en la sede de Bolonia en 1952.
Anticipemos ya, para que el público pueda introducirse desde ahora en la dimensión global de aquel momento histórico, que Lercaro, al asumir la dignidad episcopal de Bolonia en el momento de su pleno desarrollo demográfico y urbanístico de posguerra, se encontró con la necesidad de tener que hacer frente al problema acuciante de procurar, en las áreas de nueva urbanización, los terrenos que habrían de acoger, con el tiempo, las futuras organizaciones pastorales en el territorio, antes de que la edificación comercial saturase todo el conjunto de parcelas. Esto es lo que Lercaro, en los dieciséis años en los que permanece en la sede de Bolonia, logra realizar, sin gravar a las empobrecidas cajas de la curia, sino obteniéndolo directamente de los ciudadanos, según un proceso con garantía del cual hablaremos.
La historia es conocida. Pero yo la recuerdo y la anticipo para que la continuación del relato contenga, para todos los oyentes, la referencia final de la tragedia. El 12 de febrero de 1968, Lercaro, después de un episcopado excepcional que logra arrastrar a la ciudad a un estado de entusiasta perspectiva de adhesión al espíritu cristiano y a la fe, fue obligado, por una maniobra subterránea de la curia romana, promovida por personajes reaccionarios de los cabildos de San Pedro de Roma y de San Petronio de Bolonia, a dejar su diócesis para retirarse a la vida privada. Pero, ¿cómo se puede llegar a una decisión tan grave y dramática que no tiene parangón en la historia de la Iglesia católica? ¿Qué llega realmente a realizar Lercaro en el lapso de tiempo tan limitado que se le concedió? Vayamos por partes.
La construcción del espacio religioso
Authors: García Morales Soledad 
Published: May 2019

Voy a explicarles básicamente una experiencia docente; una asignatura que vengo impartiendo desde hace cuatro años en la Escuela Técnica Superior de Arquitectura de Madrid, y que comenzó por una pequeña iniciativa —un seminario de investigación sobre arquitectura y liturgia— del entonces capellán de la escuela. Y en un momento determinado, se vio la posibilidad de transformar ese seminario en una asignatura de libre configuración. De tal manera que hice los trámites, diseñé un programa, y la asignatura se ha introducido en el plan de estudios. Creo que somos la primera escuela de arquitectura de España que tiene una asignatura de esta naturaleza. Como comprenderán ustedes, es una signatura que solamente lleva cuatro años desarrollándose y para la que he tenido que partir prácticamente de cero; no porque no existiera bibliografía, sino porque el especial punto de vista que quería transmitir a mis alumnos así lo requería.
Dicho esto, quiero presentar el que constituye básicamente mi objetivo principal: cómo desarrollar en los alumnos lo que yo llamo «capacidad de pensamiento simbólico». En mi opinión, esta capacidad se encuentra en la base de la comprensión de las ideas que subyacen en un edificio sacro, y constituye un campo de investigación tan amplio —y en cierto sentido tan extraño a nuestra cultura contemporánea— que mi asignatura se propone investigar cómo tender ese puente. Por lo tanto, todavía no tenemos propuestas concretas, no hemos construido ninguna iglesia, todavía no hemos hecho ningún taller experimental. Estamos abriendo una línea de investigación, pero pensamos que estamos en el buen camino. Y esto lo veo en el entusiasmo y en la respuesta de mis alumnos, la mayoría de los cuales no son creyentes, algunos de ellos ni siquiera están bautizados o simplemente no han oído nunca hablar ni de liturgia ni de teología. Entonces, comprenderán que intentar transmitir, que intentar introducir en su corazón y en su cabeza la vibración necesaria para suscitar la creación artística supone un reto apasionante —o que yo he asumido como apasionante— y en el que posiblemente la persona que más aprenda sea yo misma.
Temporary worship places for permanent communities
Authors: Zito Carla 
Published: May 2019

When a worship place is a temporary one? What kind of construction characteristics make the difference between a temporary parish church and a permanent one? What does it mean to build a temporary worship place?
Building a place of worship comes not only from urban needs but mainly from pastoral needs and from the will of a community of having a place where meet together. This paper tells about the creation of a small prefabricated wooden church of about 450 square meters, in an area devoted to the building of the definitive parish center, outcome of a diocesan contest.
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¿Cuando un lugar de culto es temporal? ¿Qué tipo de características de construcción marcan la diferencia entre una iglesia parroquial provisional y otro definitivo? ¿Qué significa para construir un lugar de culto temporal?La construcción de un lugar de culto no sólo proviene de las necesidades urbanas, pero sobre todo de las necesidades pastorales y de la voluntad de una comunidad de tener un lugar donde se reúnen. Este artículo habla de la creación de una pequeña iglesia de madera prefabricada de unos 450 metros cuadrados, con un área dedicada a la construcción del centro parroquial definitiva, resultado de un concurso.
El espacio de encuentro personal con Dios en el entorno contemporáneo
Authors: Pérez del Prado Mercedes , Vallejo Osorno Francisco Javier 
Published: May 2019

El Mensaje del Sínodo de los Obispos expone las claves de la nueva evangelización que iluminan las respuestas de la arquitectura a los retos que plantea.
En 2012, se inaugura en Helsinki la Capilla del Silencio que ofrece un lugar de recogimiento espiritual, abierto a todas las personas. En un entorno de gran afluencia −plaza Narinkka− su llamativa forma despierta curiosidad. Una comunidad que acoge en el vestíbulo, conduce a descubrir un interior sereno que invita a la contemplación y al silencio.
La respuesta suscitada, propicia el análisis de sus cualidades arquitectónicas, cercanas a los objetivos de la nueva evangelización.
CARACTERIZAÇÃO DAS UNIDADES GEOTÉCNICAS DA PORÇÃO LESTE DA REGIÃO METROPOLITANA DE BELO HORIZONTE – MG
Authors: Reis Junior Walter dos , Parizzi Maria Giovana 
Published: May 2019

Este trabalho apresenta a caracterização das unidades geotécnicas da porção oriental da Região Metropolitana de Belo Horizonte. Essa região caracteriza-se por ser um vetor de malha urbana densa e intenso desenvolvimento, além da ocorrência de inúmeras atividades mineradoras. A geologia da área é constituída por rochas granito-gnáissicas dos Complexos Metamórficos Belo Horizonte e Caeté, seccionadas por sistemas de fraturas NW/SE e SW/NE, e rochas metassedimentares e vulcânicas dos Supergrupos Rio das Velhas, São Francisco e Espinhaço, com foliações e acamadamento com mergulhos, predominantemente, para E. A caracterização das litologias descritas teve como principal base bibliográfica o relatório do PDDI/RMBH (Plano Diretor de Desenvolvimento Integrado da Região Metropolitana de Belo Horizonte), que agrupa 10 unidades geotécnicas para toda a Região Metropolitana de Belo Horizonte. Neste trabalho a classificação geotécnica dessas unidades foi realizada a partir da descrição de 114 maciços rochosos localizados em encostas naturais e taludes de corte. Além disso, também foi avaliada a suscetibilidade para ocorrências de processos geodinâmicos. Os resultados contribuíram para a criação de um arcabouço de informações disponíveis sobre as características de unidades geotécnicas da área da RMBH.
Palavras Chave: processos geodinâmicos, comportamento geotécnico
MORAL VALUE OF LOCAL WISDOM-BASED LEARNING AT UNIVERSITY OF MUHAMMADIYAH SURABAYA: INDONESIAN CASE
Authors: Martati Badruli , Suryaningtyas Wahyuni , Hariyadi Misrin 
Published: May 2019

Purpose of Study: The development of learning model that can be used by teacher candidates and teacher's implementation thinking of national figures in learning. The goal of early-childhood as the next generation of the nation canrecognize, understand and emulate the thoughts of moral values of nationality. Local wisdom is increasingly urgent to be inserted during the learning process so that early-childhood has social and environmental character. This is in line with the depletion of natural resources and the complexity of community empowerment efforts. Local wisdom is a critical element for the success of community resource development and natural resource management. As a value, local wisdom is the values or behavior of local people living in interacting within the environment in which they live wisely. Research based upon the development on the instructional design model implemented for this study is based on the instructional design developed by Dick, Carey and Carey, The Systematic Design of Instruction. Research subjects were PG PAUD students, early-childhood students.
Methodology: Research and Development (R & D) is appropriately used for innovation since it is planned, systematic and measurable for the purpose of creating novelty or innovation in all fields. The innovation can be a product innovation, model, procedure, design, work, and strategy. In this research, the concept of R & D is used as a way of creating a model of learning in order to develop a future-oriented, effective, ready-to-use and future-developed early childhood moral.
Results: The result of lecturer's ability analysis in managing the local wisdom-based learning shows the criteria of Excellent, student activity and the completeness of local wisdom-based learning is effective, and get a positive and effective responses.
Implications/Applications: The development of early childhood moral learning based on local wisdom was developed with the instructional design model implemented in this research based on the instructional design of The Systematic Design of Instruction of Dick, Carey and Carey through 10 (ten) stages. Need assessment showedthat development of early childhood moral learning tools was needed and should be based on local wisdom.
TEACHERS’ BELIEFS AND PRACTICES OF USING YOUTUBE IN EFL CONTEXT IN MUHAMMADIYAH SENIOR HIGH SCHOOLS OF SURABAYA
Authors: Febriani Gita , Nur Hafifah Gusti 
Published: May 2019

Purpose of Study: Considering Muhammadiyah’s big contribution to education in Indonesia by establishing thousands of schools, it is thus important to understand the competence and the beliefs of teachers who teach in Muhammadiyah schools. This quantitative study investigated Muhammadiyah teachers’ beliefs and practices of using YouTube in EFL context in all Muhammadiyah Senior High Schools of Surabaya. Employing a survey design, this research aims to describe Muhammadiyah Senior High Schools of Surabaya English teachers’ beliefs and practices of using YouTube in the EFL context. 22 English teachers participated as the subjects of the research.
To obtain the data, the instrument used was a questionnaire which is copied and distributed to the targeted subjects. Interview and documentation were done to validate the results of the questionnaire. Results reveal that English teachers in Muhammadiyah Senior High Schools of Surabaya hold positive beliefs about using YouTube in the EFL context. And, despite the only view of them used it often, all the teachers had already used YouTube in their practices of teaching English. Overall, teachers’ beliefs about using YouTube in EFL context were in line with their practices.
Methodology: This research applied the quantitative technique and the design employed was survey design. Survey designs are procedures in quantitative research in which investigators administer a survey to a sample or to the entire population of people to describe the attitudes, opinions, behaviors, or characteristics of the population. Creswell continues, “Surveys help identify important beliefs and attitudes of individuals.”
Results: The results obtained from the participants were analyzed using an SPSS 17 programmer. Each participant was given a participation alphabet and the data were analyzed using descriptive analysis method. Then, the frequencies and percentages for each statement were presented in tables (see appendixes)
Implications/Applications: English teachers in Muhammadiyah Senior High Schools of Surabaya hold positive beliefs about using YouTube in the EFL context.