bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effectiveness of Steroids and Antioxidants in the Management of Cisplatin-induced Ototoxicity: A Comprehensive Systematic Review of the Literature and Network Meta-Analysis
Authors: Alghamdi Muhnnad Abdulaziz , Albeladi Shahad Mohammed , Alharthy Renad Fayez , Alharbi Ghaida Essa , Aljahdali Danah MohammedSaleh , Alaqsam Yousef Ismail , Malas Moayyad , Alsubaie Haya 
Published: November 2024

Abstract

Background:
Cisplatin efficacy in cancer therapy is hindered by dose-dependent toxicities, including ototoxicity. Its mechanisms involve cochlear damage and oxidative stress. Gender and age affect susceptibility, with limited treatment options for adults.

Objective:
To assess the effectiveness of steroids compared to antioxidants (AOs) in preventing and managing cisplatin-induced ototoxicity.

Materials and Methods:
Data were collected from multiple sources including Medline, CENTRAL, PubMed, and Springer Nature Journals. Adults and pediatrics with the clinical diagnosis of cisplatin-induced ototoxicity, interventional studies (including single-arm studies) were included. Studies with a focus on chemotherapy agents other than cisplatin were excluded.

Results:
The study encompassed 10 randomized controlled trials spanning 2004–2023 across Canada, Israel, The Netherland, Spain, Turkey, Greece, Italy, and Iran. It aimed to evaluate interventions for preventing cisplatin-induced ototoxicity, including intratympanic injections and oral dietary supplements. Based on the results of this systematic review, thiosulfate-hyaluronate gel showed a 1.3 dB reduction in hearing loss; dexamethasone injections had minimal efficacy; L-N-acetylcysteine (L-NAC) offered significant otoprotection with daily infusion; and transtympanic L-NAC showed no significant benefit. Salicylate usage yielded no decrease in hearing loss. AO dietary supplements showed no difference in results between groups. However, based on the network meta-analysis results, it appears that steroids perform best in reducing cisplatin-induced ototoxicity at higher frequencies (8000 Hz), followed by placebo and then AO.

Conclusion:
A further molecular and targeted therapy is needed to target the cyto/ototoxic activity and further prevent such deterioration in hearing and promote chemotherapy regime without ototoxic effects.
Severe Vestibular Dysfunction Following Unilateral Cochlear Implant: A Case Report and Management Approach
Authors: Al-Momani Murad , Aljohi Nada , Alruwaili Atheer M. 
Published: November 2024

Abstract
Cochlear implantation (CI) is a highly effective treatment for severe-to-profound hearing loss, but it can result in postoperative vestibular dysfunction, including vertigo and imbalance. This case report describes a 22-year-old female who developed severe vertigo and imbalance following right ear CI surgery. Audiological assessment confirmed normal hearing in the left ear and profound sensorineural hearing loss in the right ear. Vestibular tests revealed significant dysfunction, including left-beating spontaneous nystagmus, vestibular hypofunction, and abnormal saccular function in the implanted ear. This case underscores the prevalence of vestibular complications post-CI, reported in up to 75% of recipients. Comprehensive preoperative vestibular assessment is essential for identifying potential risks and guiding surgical decisions, such as choosing between unilateral and bilateral implantation. Early identification and management of vestibular issues can improve outcomes and quality of life for CI patients.
Sarcopenia-associated factors and their bone mineral density levels in middle-aged and elderly male type 2 diabetes patients
Authors: Chen De-Qing , Wu Yong-Xin , Zhang Ying-Xiao , Yang Hai-Ling , Huang Huan-Huan , Lv Jiang-Yan , Xiao Qian 
Published: November 2024

BACKGROUND
Chronic hyperglycemia can damage the microcirculation, which impairs the function of various organs and tissues and predisposes individuals to chronic complications. Sarcopenia (SP) is the age-related decline in muscle mass and function that contributes to the sequelae of type 2 diabetes. In particular, diabetic patients are at higher risk of SP because of insulin resistance, chronic inflammation, and decreased physical activity.
AIM
To identify SP-associated factors in middle-aged and elderly male type 2 diabetes mellitus (T2DM) patients and their correlation with bone mineral density (BMD).
METHODS
A retrospective analysis was conducted on 196 middle-aged and elderly male T2DM inpatients in the First Affiliated Hospital of Chongqing Medical University between June 2021 and June 2023, with 60 concurrent healthy individuals as the control group. Differences in general information, blood biochemistry, glycosylated hemoglobin, muscle strength, and detection rate of SP were compared between groups. The BMD, appendicular skeletal muscle (ASM), and fat mass, as well as grip strength and gait speed, were determined for each patient, and the ASM index (ASMI) was counted. The quantitative data were subjected to correlation and logistic regression analyses to identify risk factors for SP.
RESULTS
Fifty-one of the 196 middle-aged and elderly male T2DM patients were diagnosed with SP, which accounted for 26.02%. The middle-aged and elderly T2DM patients with SP exhibited a longer diabetes mellitus (DM) course and a lower body mass index (BMI) and 25(OH)D3 compared with the non-SP patients. The T2DM + SP patients exhibited lower BMI, ASM, ASMI, left- and right-hand grip strength, gait speed, and muscle and fat mass of the upper and lower limbs compared with the diabetic non-SP patients. The femoral neck, total hip, and lumbar spine L1-4 BMD were markedly lower in T2DM + SP patients compared with those in the non-SP diabetics. Long-term DM course, low BMI, and low BMD of the femoral neck, lumbar spine L1-4, and total hip were identified as risk factors for the development of SP.
CONCLUSION
T2DM patients are at risk for SP; however, measures can be taken to prevent the related risk factors.
Peroxisome proliferator-activated receptor gamma mutation in familial partial lipodystrophy type three: A case report and review of literature
Authors: Wu Chao-Jun , Liu Hao , Tu Li-Juan , Hu Jiong-Yu 
Published: November 2024

BACKGROUND
Familial partial lipodystrophy disease (FPLD) is a collection of rare genetic diseases featuring partial loss of adipose tissue. However, metabolic difficulties, such as severe insulin resistance, diabetes, hypertriglyceridemia, and hypertension frequently occur alongside adipose tissue loss, making it susceptible to misdiagnosis and delaying effective treatment. Numerous genes are implicated in the occurrence of FPLD, and genetic testing has been for conditions linked to single gene mutation related to FPLD. Reviewing recent reports, treatment of the disease is limited to preventing and improving complications in patients.
CASE SUMMARY
In 2017, a 31-year-old woman with diabetes, hypertension and hypertriglyceridemia was hospitalized. We identified a mutation in her peroxisome proliferator-activated receptor gamma (PPARG ) gene, Y151C (p.Tyr151Cys), which results in a nucleotide substitution residue 452 in the DNA-binding domain (DBD) of PPARG . The unaffected family member did not carry this mutation. Pioglitazone, a PPARG agonist, improved the patient’s responsiveness to hypoglycemic and antihypertensive therapy. After one year of treatment in our hospital, the fasting blood glucose and glycosylated hemoglobin of the patient were close to normal.
CONCLUSION
We report a rare PPARG mutation, Y151C, which is located in the DBD of PPARG and leads to FPLD, and the preferred agent is PPARG agonists. We then summarized clinical phenotypic characteristics of FPLD3 caused by PPARG gene mutations, and clarified the relationship between different mutations of PPARG gene and the clinical manifestations of this type of FPLD. Additionally, current treatments for FPLD caused by PPARG mutations are reviewed.
ALIENAÇÃO PARENTAL: CONCEPÇÕES, ASPECTOS PSICOJURÍDICOS E SOLUÇÕES JURÍDICAS NO ÂMBITO DO DIREITO BRASILEIRO
Authors: Pereira Amanda Karolyne Vieira , Andrade Thiago Borges 
Published: November 2024

A presente pesquisa é apresentada como trabalho de conclusão de curso e tem como objetivo geral verificar o uso dos dispositivos legais e doutrinas na prevenção da alienação parental, bem como seu uso para reestabelecer o relacionamento entre o genitor alienado com a criança ou adolescente. Os objetivos específicos pretendem apontar a definição da alienação parental; identificar comportamentos de um possível alienador parental; compreender o uso de dispositivos para solucionar casos comprovados de alienação parental, e; verificar a existência de meios de prevenção da alienação parental através das leis e doutrinas psicojurídicas. Para isso, temos uma revisão bibliográfica de caráter descritivo e abordagem qualitativa com a utilização de livros, dissertações, teses e artigos. O conceito será apresentado a fim de estruturar uma linha teórica em torno da doutrina jurídica, bem como das considerações acerca dos impactos da prática no seio da família. Espera-se elaborar estratégias de prevenção e apontar caminhos jurídicos para resolver questões aprofundadas sobre o assunto.
Combined Vojta and Bobath concepts therapy effect and physical exercises on foot balance and motor control in children with infantile cerebral palsy
Authors: Bartik Peter , Popescu Andreea , Plăstoi Camelia-Daniela , Niculescu Bogdan , Šagát Peter , Prieto González Pablo , AL Jasser Ibrahim , Ioan Tohănean Dragoș , Turcu Ioan , Kubíková Eliška 
Published: November 2024

Background: Ensuring independent locomotion is one of the primary goals of therapeutic intervention in children with infantile cerebral palsy (ICP). This study aimed to evaluate the foot and balance developmental changes in children with ICP after independent walking began utilizing Bobath, Vojta, and combined concepts for therapy. Methodology: 12 children (5 girls, 7 boys) aged 2-5 years diagnosed with ICP were distributed into three groups. Group I – 4 subjects treated with Vojta therapy, Group II – 4 subjects treated with Bobath therapy, and Group III – 4 subjects treated with a combined therapy. The assessment of the subjects included the Berg scale, the Gross Motor Function Classification System (GMFCS), and a Stabilometry footboard PoData 2.00. Results: Group I reported an improvement in balance, and Group II reported an improvement in muscle tone. Group III reported a significant improvement in coordination and balance through rebalancing the plantar weight distribution on each leg. Conclusions: This study highlights and recommends combining Bobath and Vojta's approaches for advanced impact on foot balance and motor control in children with infantile cerebral palsy.
The association of Whole and Segmental Body Composition and Anaerobic Performance in Crossfit® athletes: sex differences and performance prediction
Authors: Ponce-García Tomás , García-Romero Jerónimo , Carrasco-Fernández Laura , Castillo-Dominguez Alejandro , Benítez-Porres Javier 
Published: November 2024

The main purpose of this study was to establish the association between total and segmental body composition (BC) variables and anaerobic performance and to create optimal models that best predict such performance in CrossFit® (CF) athletes. Fifty athletes, 25 males and 25 females (age: 33.26 ± 6.81 years; body mass: 72.57 ± 12.17 kg; height: 169.55 ± 8.71 cm; BMI: 25.06 ± 2.31 kg·m−2) were recruited to participate and underwent BC analysis using dual-energy X-ray absorptiometry (DXA) and an all-out laboratory test on a cycle ergometer (Wingate) to determine their anaerobic performance. The results show a significant correlation between BC values and performance, ranging from moderate (r = -0.34, p = 0.015) to near-perfect (r = 0.96, p < 0.01). Furthermore, the created performance prediction models exhibited predictive capacities ranging from 19% (p = 0.017) to 93% (p < 0.001). All prediction models were created using total or segmental lean mass variables, excluding others. The studied body composition and performance variables found significant differences between males and females. The findings demonstrate that body composition variables are crucial indicators of anaerobic performance in CF athletes. In this regard, it may be advisable for sports performance professionals to consider this information when monitoring athletes throughout the season or designing specific training programs. Similarly, the use of predictive equations could be a useful tool for estimating peak and mean power values.
Ellen Churchill Semple: as montanhas, a circulação humana e as mudanças territoriais: a geografia como ecologia humana (comentários & tradução)
Authors: Barros Nilson Cortez Crocia de 
Published: November 2024

O trabalho consiste na tradução para o Português do texto da antropogeógrafa norte-americana Ellen Semple dedicado ao estudo das influências exercidas pelas montanhas, como geofator, sobre os padrões de povoamento das populações humanas e sobre as mudanças histórico-espaciais. As ideias de progresso e difusão cultural guiam o texto. A tradução é precedida por uma análise do valor desta contribuição para a compreensão da história e das tendências atuais de organização do Espaço Geográfico.
SO SÁNH HIỆU QUẢ XỬ LÝ NƯỚC THẢI NUÔI TRỒNG THỦY SẢN GIỮA CÂY RAU NGỔ (Enydra fluctuans Lour) VÀ CÂY RAU MUỐNG (Ipomoea aquatica)
Authors: Trần Hạnh , Dương Huyền 
Published: November 2024

Nước thải nuôi trồng thủy sản có nồng độ chất ô nhiễm hữu cơ vừa phải rất thích hợp cho việc sử dụng thực vật thủy sinh để xử lý. Nghiên cứu được thực hiện với 3 nghiệm thức, trong đó rau muống và rau ngổ được chọn để xử lý nước thải có chiều cao trung bình khoảng 10 cm, trồng trong mô hình (thùng xốp) có mật độ 100 cây/m2. Kết quả nghiên cứu cho thấy rau ngổ và rau muống thích nghi và phát triển tốt trong môi trường nước thải nuôi lươn được đặc trưng bởi sự gia tăng các chỉ tiêu về sinh khối. Đặc biệt, khả năng xử lý chất ô nhiễm hữu cơ của cây rau muống cao hơn cây rau ngổ. Kết quả đạt được qua thí nghiệm như sau: Sau 20 ngày thí nghiệm, mật độ và sinh khối trung bình của rau muống tăng lần lượt là 1.32 và 4.9 lần, còn rau ngổ là 1.69 và 4 lần. pH nước thải sau xử lý dao động từ 7 ÷ 8. Tổng chất rắn lơ lửng (TSS) của nước thải sau xử lý giảm khoảng 78%. Nồng độ COD giảm 70% ở nghiệm thức trồng rau ngổ và 83% ở nghiệm thức trồng rau muống.
Nghiên cứu ương nuôi giống cá Chình hoa (Anguilla marmorata) tại Công ty TNHH MTV Thủy sản Nhật Nam tỉnh Tuyên Quang.
Authors: Phạm Trang , Trương Linh , Nguyễn Hiền , Nguyễn Dân 
Published: November 2024

Thực nghiệm ương nuôi giống cá Chình hoa (Anguilla marmorata) trong bể tại huyện Na Hang Tuyên Quang với mật độ ương giống 500 con/m3; Thức ăn tổng hợp dạng bột có hàm lượng đạm tối thiểu (P) = 48-50%, lipid: ≥ 4,0, chất xơ ≤ 3,0, độ ẩm ≤ 10; canxi 2,0 - 5,0; tro ≤ 17 và có trộn thêm Vitamin, men tiêu hóa, khoáng chất; Khẩu phần ăn: 3-5% khối lượng cá/ngày, điều chỉnh theo khả năng bắt mồi của cá; Thời điểm cho cá ăn vào lúc 8 giờ và 18-19 giờ hàng ngày; pH nước từ 7 - 8; nhiệt độ 23-30oC; DO >5 mg/l . Cho thấy kết quả ương nuôi cá giống cho thấy: qua 3 đợt thả cá giống, tốc độ sinh trưởng của cá khá tốt. Đợt đầu tỷ lệ sống thấp nhất (73%), càng về sau tỷ lệ sống càng cao (80%). Khối lượng tăng trung bình 6-7 gam/tháng, chiều dài 4-6cm/tháng. Khối lượng tổng đàn = 1.993,0 kg, cỡ trung bình ± 50 gam/con.
Đánh giá công tác Đăng ký cấp giấy chứng nhận quyền sử dụng đất trên địa bàn huyện Đô Lương, tỉnh Nghệ An giai đoạn 2019 – 2021
Authors: Nguyễn Thuỷ , Nguyễn Linh , Trần Anh , Vũ Hảo , Nguyễn Nhuận , Nguyễn Thảo 
Published: November 2024

Công tác cấp giấy chứng nhận quyền sử dụng đất, quyền sở hữu nhà ở và tài sản khác gắn liền với đất trên địa bàn huyện Huyện Đô Lương, tỉnh Nghệ An thời gian qua mặc dù đã có những kết quả đáng khích lệ. Tuy nhiên, bên cạnh đó vẫn còn một số khó khăn, tồn tại cần phải khắc phục. Vì vậy, một đề tài nghiên cứu đã được tiến hành nhằm đánh giá thực trạng và hiệu quả của công tác cấp giấy chứng nhận quyền sử dụng đất, từ đó đưa ra được những giải pháp có tính khả thi. Đề tài đánh giá công tác cấp giấy chứng nhận quyền sử dụng đất dựa trên số liệu thứ cấp và điều tra 120 người sử dụng đất và 20 cán bộ chuyên môn. Kết quả tổng hợp số liệu cho thấy, Giai đoạn 2019 – 2021 huyện Đô Lương có 18.999 hồ sơ xin cấp giấy chứng nhận đất ở, với tổng diện tích là 1.502,77 ha. Số hồ sơ được phê duyệt cấp tổng cả 3 năm là 13.295 hồ sơ, chiếm 69,98%. Kết quả đăng ký, cấp giấy chứng nhận quyền sử dụng đất nông nghiệp: có 9.337 hồ sơ xin cấp với tổng diện tích là 4.716,59ha. Số hồ sơ được phê duyệt là 6.605 hồ sơ, đạt tỷ lệ bình quân là 70,74 %. Đã tìm ra được 10 yếu tố ảnh hưởng đến công tác đăng ký cấp giấy chứng nhận quyền sử dụng đất. Từ những kết quả này, nhóm nghiên cứu cũng đã đề xuất 02 nhóm giải pháp có tính khả thi cao nhằm đẩy nhanh công tác cấp giấy chứng nhận quyền sử dụng đất trên địa bàn nghiên cứu.
An updated parameterization of the unstable atmospheric surface layer in the Weather Research and Forecasting (WRF) modeling system
Authors: Namdev Prabhakar , Sharan Maithili , Srivastava Piyush , Mishra Saroj Kanta 
Published: November 2024

Abstract. The accurate parameterization of atmospheric surface layer processes is crucial for weather forecasts using numerical weather prediction models. Here, an attempt has been made to improve the surface layer parameterization in the Weather Research and Forecasting model version 4.2.2 (WRFv4.2.2) by implementing similarity functions proposed by Kader and Yaglom (1990) to make it consistent in producing the transfer coefficient for momentum observed over the tropical region (Srivastava and Sharan, 2015). The surface layer module in WRFv4.2.2 is modified in such a way that it contains the commonly used similarity functions for momentum (φm) and heat (φh) under convective conditions instead of the existing single functional form. The updated module has various alternatives of φm and φh, which can be controlled by a flag introduced in the input file. The impacts of utilizing different functional forms have been evaluated using the bulk flux algorithm as well as real-case simulations with the WRFv4.2.2 model. The model-simulated variables have been evaluated with observational data from a flux tower at Ranchi (23.412° N, 85.440° E), India, and the ERA5-Land reanalysis dataset. The transfer coefficient for momentum simulated using the implemented scheme is found to agree well with its observed non-monotonic behavior in convective conditions (Srivastava and Sharan, 2021). The study suggests that the updated surface layer scheme performs well in simulating the surface transfer coefficients and could be potentially utilized for the parameterization of surface fluxes under convective conditions in the WRF model.
<span>X&acirc;y dựng hệ thức lượng trong tứ gi&aacute;c nội tiếp đường tr&ograve;n v&agrave; một số &aacute;p dụng</span>
Authors: Nguyễn Thị Thanh Trim , Trần Văn Sự 
Published: November 2024

Bài viết xây dựng các hệ thức lượng cho một tứ giác nội tiếp đường tròn. Công thức của Brahmagupta về tính diện tích của tứ giác nội tiếp được giới thiệu và chứng minh chi tiết. Sau đó, chúng tôi xây dựng các công thức lượng giác để tính các góc của một tứ giác nội tiếp trong đường tròn như công thức tính sin, công thức tính cosin và một số công thức tính chiều cao liên quan. Bên cạnh đó một số công thức tính diện tích của tam giác, hình bình hành, hình thoi, hình chữ nhật và hình vuông được mô tả lại như một áp dụng trực tiếp công thức dạng Brahmagupta. Một số ví dụ minh họa cho các bài toán liên quan đến tứ giác nội tiếp đường tròn được đề xuất để áp dụng các kết quả đạt được.
ANALYSIS OF REPRODUCTION PROCESSES OF THE POPULATION OF KAZAKHSTAN
Authors: Mananov B. B. , Iskakov U. M. , Ruzieva E. A. 
Published: November 2024

The purpose of the study is to assess, based on the in-depth analysis, the current state and dynamics of the processes of reproduction of the population of Kazakhstan and its regions.Research methodology. The methodological basis for this study was statistical methods: retrospective, current and prospective analysis, time series, index methods, comparison of open access statistical data characterizing population reproduction processes.The official statistical information of the Bureau of National Statistics ASPiR of the Republic of Kazakhstan (BNS), presented on the official website, was used as a data source.Originality (value) of the study. The main value of this study lies in the analysis of the mutual influence of changes in the age-sex structure and population reproduction processes based on forecast calculations.Results of the study. Based on the analysis of the age-sex structure of the population, the main trends and mutual influence of “demographic waves” and indicators of reproduction of the population of Kazakhstan were identified, an analysis of changes in the main indicators of the number and age-sex structure, natural movement of the population was carried out based on forecast calculations.
SOCIO-ECONOMIC DETERMINANTS OF EDUCATIONAL INEQUALITY IN KAZAKHSTAN: QUANTITATIVE AND QUALITATIVE ANALYSIS
Authors: Sagidolda N. , Zhanbyrbaeva A. N. , Argynbaeva Zh. Zh. 
Published: November 2024

The purpose of the study is to identify and analyses the socio-economic factors influencing educational inequality in urban and rural schools in Kazakhstan.The research methodology includes the use of quantitative methods such as descriptive statistics, comparative and correlation analysis, and regression analysis to identify the impact of population income and the level of digitalisation on educational outcomes. Additionally, focus groups were conducted with participants from different regions to investigate subjective factors such as family values, educational patterns and access to educational resources.The originality of the study lies in the integrated approach, combining quantitative data and qualitative methods, which allows for a deeper understanding of the relationship between socio-economic factors and educational outcomes.The results of the study showed that urban school students consistently perform better on the UNT, which is associated with access to better educational resources, qualified teachers and the Internet. Correlation analysis revealed a moderate positive correlation between the number of fixed Internet subscribers and average UNT scores, which underlines the importance of digitalisation in educational processes. At the same time, the weak correlation between household income and UNT scores indicates the need for a more detailed analysis of factors affecting the quality of education, such as infrastructure and human resources policy in education. This study emphasises the importance of developing support measures for rural schools and digital infrastructure.
The emergence of feminist technoscience in the nordics
Authors: Kirpichenko Maria , Moratti Sofia 
Published: November 2024

Our second interviewee for this special issue is Professor is Cecilia Åsberg, a leading figure in Feminist STS. She is a professor at the Department of Thematic Studies (TEMA) at Linköping University (https://liu.se/en/organisation/liu/tema) and the founder of the Posthumanities Hub (https://posthumanitieshub.net). Her research revolves around the natural or non-human as opposed to the human, in a world shaped by technoscience and environmental change. Her career narrative was incredibly engaging, prompting us to collaborate with her on editing the interview to give it a more cohesive and speech-like flow. Our pleasant one-hour conversation revolved around the themes of Feminist STS in the Nordics and academia as a community.