bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of a culturally tailored mobile health lifestyle intervention on cardiovascular health among African Americans with preexisting risk factors: The FAITH! Trial
Authors: Lalika Mathias , Jenkins Sarah , Hayes Sharonne N , Jones Clarence , Burke Lora E , Cooper Lisa A , Patten Christi A , Brewer LaPrincess C 
Published: November 2024

Background African Americans have a higher prevalence of cardiovascular risk factors, leading to higher cardiovascular disease mortality than White adults. Our culturally tailored mobile health (mHealth) lifestyle intervention ( FAITH! App) has previously demonstrated efficacy in promoting ideal cardiovascular health in African Americans. Methods We conducted a secondary analysis from a cluster randomized controlled trial among African-Americans from 16 churches in Minnesota that compared the FAITH! App to a delayed intervention control group. A subgroup of participants with ≥ 1 diagnosis of overweight/obesity, hyperlipidemia, hypertension, or diabetes was examined. The primary outcome was a change in LS7 score—a measure of cardiovascular health ranging from poor to ideal (range 0–14 points)—at 6-months post-intervention. Results The analysis included 49 participants (intervention group: n = 20; mean age 58.8 years, 75% female; control group: n = 29, mean age 52.5 years, 76% female) with no significant baseline differences in cardiovascular risk factors. Compared to the control group, the intervention group showed a greater increase in LS7 score across all cardiovascular risk factors at 6-months post-intervention, with statistically significant differences among those with overweight/obesity (intervention effect 1.77, p < 0.0001) and 2+ or 3+ cardiovascular risk factors (1.00, p = 0.03; 1.09, p = 0.04). The intervention group demonstrated a higher increase in the percentage of participants with intermediate or ideal LS7 scores than the control group, although these differences were not statistically significant. Conclusions Our culturally tailored mHealth lifestyle intervention was associated with significant increases in LS7 scores among African Americans with preexisting cardiovascular risk factors, suggesting its efficacy in improving cardiovascular health among this population.
Machine learning models for predicting return to sports after anterior cruciate ligament reconstruction: Physical performance in early rehabilitation
Authors: Hwang Ui-jae , Kim Jin-seong , Kim Keong-yoon , Chung Kyu-sung 
Published: November 2024

Objective Return to sports (RTS) after anterior cruciate ligament reconstruction (ACLR) is a crucial surgical success measure. In this study, we aimed to identify the best-performing machine learning models for predicting RTS at 12 months post-ACLR, based on physical performance variables at 3 months post-ACLR. Methods This case-control study included 102 patients who had undergone ACLR. The physical performance variables measured 3 months post-ACLR included the Biodex balance system, Y-balance test, and isokinetic muscle strength test. The RTS outcomes measured at 12 months post-ACLR included the single-leg hop test, single-leg vertical jump test, and Tegner activity score. Six machine learning algorithms were trained and validated using these data. Results Random forest models in the test set best predicted the RTS success based on the single-leg hop test (area under the curve [AUC], 0.952) and Tegner activity score (AUC, 0.949). Gradient boosting models in the test set best predicted the RTS based on the single-leg vertical jump test (AUC, 0.868). Conclusion Modifiable factors should be considered in the early rehabilitation stage after ACLR to enhance the possibility of a successful RTS.
Modified Slow-Strain-Rate Tensile Testing Method for Evaluation of Room-temperature Hydrogen Embrittlement Susceptibility and Its Application to 23Cr2Ni4MoV Steel
Authors: Lv Sanshu , Chen Xuedong , Fan Zhichao , Zhou Yu , Yang Hao , Zhang Qiang , Chi Mingjian , Li Yue 
Published: November 2024

AbstractTo evaluate the room-temperature hydrogen embrittlement susceptibility (HES) of high-pressure hydrogen storage vessels, a modified slow-strain-rate tensile (MSSRT) testing method was proposed for effectively aligning with their actual operating conditions. The effectiveness of the MSSRT testing method in evaluating the room-temperature HES of steels under high pressure was validated by comparing the results obtained using the conventional slow strain rate tensile (SSRT) and proposed MSSRT testing methods for 30CrMo steel, which is widely used for manufacturing high-pressure hydrogen storage vessels. The tensile properties and fracture morphologies of 23Cr2Ni4MoV steel were then examined using the MSSRT testing method under 35 MPa hydrogen and nitrogen at room temperature. Results indicate that 35 MPa hydrogen exerted a marginal effect on the tensile properties of 23Cr2Ni4MoV steel at room temperature when considering the MSSRT testing method; moreover, the test specimen basically exhibited macroscopic ductile fracture. Furthermore, obvious surface cracking was observed on the fractured specimen tested under hydrogen, whereas surface cracking was not observed on the fractured specimen tested under nitrogen. Hence, the relative reduction of area and surface cracking are necessary criteria for evaluating the room-temperature HES of steels using the MSSRT testing method. Overall, 23Cr2Ni4MoV steel might be unsuitable for manufacturing high-pressure hydrogen storage vessels.
A dispensable SepIVA orthologue in Streptomyces venezuelae is associated with polar growth and not cell division
Authors: Sen Beer Chakra , Mavi Parminder Singh , Irazoki Oihane , Datta Susmita , Kaiser Sebastian , Cava Felipe , Flärdh Klas 
Published: November 2024

Abstract
Background
SepIVA has been reported to be an essential septation factor in Mycolicibacterium smegmatis and Mycobacterium tuberculosis. It is a coiled-coil protein with similarity to DivIVA, a protein necessary for polar growth in members of the phylum Actinomycetota. Orthologues of SepIVA are broadly distributed among actinomycetes, including in Streptomyces spp.

Results
To clarify the role of SepIVA and its potential involvement in cell division in streptomycetes, we generated sepIVA deletion mutants in Streptomyces venezuelae and found that sepIVA is dispensable for growth, cell division and sporulation. Further, mNeonGreen-SepIVA fusion protein did not localize at division septa, and we found no evidence of involvement of SepIVA in cell division. Instead, mNeonGreen-SepIVA was accumulated at the tips of growing vegetative hyphae in ways reminiscent of the apical localization of polarisome components like DivIVA. Bacterial two-hybrid system analyses revealed an interaction between SepIVA and DivIVA. The results indicate that SepIVA is associated with polar growth. However, no phenotypic effects of sepIVA deletion could be detected, and no evidence was observed of redundancy with the other DivIVA-like coiled-coil proteins Scy and FilP that are also associated with apical growth in streptomycetes.

Conclusions
We conclude that S. venezuelae SepIVA, in contrast to the situation in mycobacteria, is dispensable for growth and viability. The results suggest that it is associated with polar growth rather than septum formation.
Prospective multicenter study of camrelizumab in real-world settings for asian patients with esophageal squamous cell carcinoma
Authors: Li Tingting , Dai Yaqing , Fu Xiaobin , Cai Qunrong , Ke Dongmei , Yao Qiwei , Li Jiancheng 
Published: November 2024

Abstract
Background
In this study, we aimed to evaluate the real-world efficacy and safety of camrelizumab and identify clinicolaboratory factors that predict treatment outcomes in patients with unresectable advanced, recurrent, or metastatic esophageal squamous cell carcinoma (ESCC) receiving camrelizumab.

Methods
Herein, 174 patients with unresectable advanced, recurrent, or metastatic ESCC treated with camrelizumab monotherapy (n = 30), camrelizumab + chemotherapy (CT; n = 91), and camrelizumab + radiotherapy (RT; n = 53) between October 1, 2019 and October 1, 2022 were included.

Results
The median follow-up time was 20 months (range, 1–34 months). The median progression-free survival (PFS) and overall survival (OS) of the whole cohort were 8 months [95% confidence interval (CI), 6.5–9.5 months] and 14 months (95% CI, 11.2–16.8 months), respectively. After multivariate analysis, receiving > 4 cycles of camrelizumab was identified as an independent predictor of better PFS [hazard ratio (HR), 0.56; 95% CI, 0.38–0.827; P = 0.004] and OS (HR, 0.532; 95% CI, 0.341–0.83; P = 0.005). An intermediate-to-poor lung immune prognostic index (LIPI) was identified as an independent predictor of worse PFS (HR, 1.505; 95% CI, 1.032–2.196; P = 0.034) and OS (HR, 1.657; 95% CI, 1.094–2.51; P = 0.017). The disease control rate of patients in the camrelizumab monotherapy group, camrelizumab + CT group, and camrelizumab + RT group was 92.3% (95% CI, 74.9–99.1%), 90.6% (95% CI, 82.3–95.9%), and 96.1% (95% CI, 86.8–99.5%), respectively. The treatment-related adverse events (AEs) of grade 3 or higher were reported in 67 patients (38.5%). The most common treatment-related AEs were decreased neutrophil count (23.0%), decreased white blood cell count (19.5%), anemia (7.5%), and pneumonitis (4.6%). One patient (0.6%) died from a treatment-related AE of immune checkpoint inhibitor-induced myocarditis.

Conclusion
Camrelizumab was safe and effective as both monotherapy and part of a combination therapy. Longer PFS and OS were associated with receiving > 4 cycles of camrelizumab and having a good LIPI. LIPI can be used as a prognostic biomarker for ESCC patients receiving camrelizumab + RT.

Trial registration
ClinicalTrial.gov Identifier: CHICTR2000039499. Registered: 19th October 2020.
Evaluation of the therapeutic relevance of architectural aspects in child and adolescent psychiatric institutions from the perspective of architects and senior physicians
Authors: Fornefeld Dustin , Schmoll-Klute Fabian , Halswick Daniel , Schmidt Peter , Scheiderer Marie-Léne , Reuter Lynn , Brockmann Katharina , Pfersich Anna , Fricke Oliver 
Published: November 2024

Abstract
Objective
The concept of “Healing Architecture” addresses the relevance of design and architectural issues on the outcome of medical and therapeutic treatment in hospitals. The questionnaire ARCHI was developed to record data on the opinion of different groups of users on the architectural design of their therapeutic environment in departments of child and adolescent psychiatry.

Method
A Questionnaire-based cross-sectional study was conducted in two phases between 2020 and 2022 using ARCHI to gather the perspectives of senior physicians and architects on the significance of architectural design in German child and adolescent psychiatric facilities.

Results
In the survey of the senior physicians, 49 heads of child and adolescents psychiatric departments initiated the survey, and 73.5% (n = 36) of them completed the questionnaire in its entirety. During the survey for the architect-specific, 145 individuals commenced the survey, and 60.7% of them completed the questionnaire (n = 88). Significant differences between architects and senior physicians became visible for four of the 93 items, namely “environment of the hospital”, “structure of building”, “labelling of floors” and “visible cleanliness”.

Conclusions
Although senior physicians and architects were characterized by the same opinions on the relevance of architectural design on therapeutic issues for the major part of issues, differences could be obtained for several aspects which are important for the architectural planning of new departments and hospitals. It remains open why both professional groups had different point of views on these four aspects of hospital design which should be clarified to improve the process of hospital development in the future.
Community utilization of a co-created COVID-19 testing program in a US/Mexico border community
Authors: Reyes Breanna J. , Calvillo Stephenie Tinoco , Escoto Arleth A. , Lomeli Angel , Burola Maria Linda , Gay Luis , Cohen Ariel , Villegas Isabel , Salgin Linda , Cain Kelli L. , Pilz Dylan , Watson Paul , Oswald Bill , Arevalo Cesar , Sanchez Jessica , Richardson Marjorie , Nelson Jennifer , Villanueva Pricilla , McGaugh Garrett , Zaslavsky Ilya , Tukey Robert H. , Stadnick Nicole A. , Rabin Borsika A. , Laurent Louise C. , Seifert Marva 
Published: November 2024

Abstract
Background
The COVID-19 pandemic exposed several health disparities experienced by underserved and Latino/a communities, including inequitable access to COVID-19 testing.

Objective and Goals
To describe the utilization of a community-driven and culturally-tailored testing model on COVID-19 testing in an underserved Latino/a community in San Diego.

Methods
The Community-driven Optimization of COVID-19 testing to Reach and Engage Underserved Areas for Testing Equity (CO-CREATE) project implemented a community co-designed COVID-19 testing program in partnership with a Federally Qualified Health Center in a US/Mexico border community.

Results
Between May 2021 and March 2023, 24, 422 COVID-19 PCR tests were administered to 13,253 individuals, among whom 93% percent identified as Latino/a, 57% spoke Spanish in the home, and 38% resided in our target community adjacent to the US/Mexico border, San Ysidro. Based on a subset of available county testing data, CO-CREATE accounted for nearly 12% of all COVID-19 tests reported for San Ysidro residents. Over the course of the project, we estimated that nearly 17% of all San Ysidro residents were tested for COVID-19 through the CO-CREATE project.

Conclusion
These findings highlight the success and reach of this culturally responsive and community co-designed COVID-19 testing program, within a Latino/a border community. Future public health interventions should focus on identifying testing barriers and design appropriate strategies to ensure equitable access to resources and testing uptake for all community members.
From infected to recovered: the mediating role of sleep quality between self-compassion, social support and COVID-19 psychosomatic symptoms
Authors: Chen Outong , Guan Fang , Zhan Chengqing , Li Ying 
Published: November 2024

Abstract
Background
Recent research has shown significant individual differences in COVID-19 psychosomatic symptoms. However, there has been a lack of studies investigating the influence of physical and psychological factors on these symptoms and their underlying mechanisms. This study aims to fill this gap by investigating the predictive role of self-compassion and social support on COVID-19 psychosomatic symptoms, as well as the potential mediating role of sleep quality.

Methods
Data were collected from 636 participants infected with COVID-19 during the early post-pandemic reopening phase in China. The measurement tools used in the current study included the Self-Compassion Scale, the Perceived Social Support Scale, Self-Rating Scale of Sleep, and a COVID-19 Psychosomatic Symptom Diary.

Results
A structural equation model revealed that: (1) social support directly predicts COVID-19 psychosomatic symptoms; (2) sleep quality fully mediates the relationship between self-compassion and COVID-19 psychosomatic symptoms; and (3) sleep quality partially mediates the relationship between social support and COVID-19 psychosomatic symptoms.

Conclusions
These findings not only confirm previous research but also provide new insights into the intricate interplay between psychological and physical factors and their influence on COVID-19 psychosomatic symptoms. The implications of these findings may inform the development of targeted rehabilitation programs in the post-pandemic era of the “new normal”.

Clinical trial number
Not applicable.
Spatiotemporal characterization of extracellular matrix maturation in human artificial stromal-epithelial tissue substitutes
Authors: Ávila-Fernández Paula , Etayo-Escanilla Miguel , Sánchez-Porras David , Fernández-Valadés Ricardo , Campos Fernando , Garzón Ingrid , Carriel Víctor , Alaminos Miguel , García-García Óscar Darío , Chato-Astrain Jesús 
Published: November 2024

Abstract
Background
Tissue engineering techniques offer new strategies to understand complex processes in a controlled and reproducible system. In this study, we generated bilayered human tissue substitutes consisting of a cellular connective tissue with a suprajacent epithelium (full-thickness stromal-epithelial substitutes or SESS) and human tissue substitutes with an epithelial layer generated on top of an acellular biomaterial (epithelial substitutes or ESS). Both types of artificial tissues were studied at sequential time periods to analyze the maturation process of the extracellular matrix.

Results
Regarding epithelial layer, ESS cells showed active proliferation, positive expression of cytokeratin 5, and low expression of differentiation markers, whereas SESS epithelium showed higher differentiation levels, with a progressive positive expression of cytokeratin 10 and claudin. Stromal cells in SESS tended to accumulate and actively synthetize extracellular matrix components such as collagens and proteoglycans in the stromal area in direct contact with the epithelium (zone 1), whereas these components were very scarce in ESS. Regarding the basement membrane, ESS showed a partially differentiated structure containing fibronectin-1 and perlecan. However, SESS showed higher basement membrane differentiation, with positive expression of fibronectin 1, perlecan, nidogen 1, chondroitin-6-sulfate proteoglycans, agrin, and collagens types IV and VII, although this structure was negative for lumican. Finally, both ESS and SESS proved to be useful tools for studying metabolic pathway regulation, revealing differential activation and upregulation of the transforming growth factor-β pathway in ESS and SESS.

Conclusions
These results confirm the relevance of epithelial-stromal interaction for extracellular matrix development and differentiation, especially regarding basement membrane components, and suggest the usefulness of bilayered artificial tissue substitutes to reproduce ex vivo the extracellular matrix maturation and development process of human tissues.

Graphical Abstract
Improving hospital care for people who use drugs: deliberative process development of a clinical guideline for opioid withdrawal management
Authors: Wickremsinhe Marisha , Holland Adam , Scott Jenny , Gittins Rosalind , Brown Michael , Noctor Adrian ‘Bean’ , Lewer Dan , Hope Vivian , Eastwood Niamh , Harris Magdalena 
Published: November 2024

Abstract
Background
Management of opioid withdrawal in hospital settings is crucial to improve treatment completion and health outcomes among patients who use opioids, such as heroin. Evidence-based clinical guidelines can support responsive provision of opioid substitution therapy (OST). In England there is no standardised application of guidance for substance dependence management across National Health Service (NHS) Hospitals. A recent review of NHS hospital policies identified varying approaches to managing opioid withdrawal and procedural barriers to timely medication.

Objective
To develop a clinical guideline for opioid withdrawal management in acute NHS hospital trusts to be tested and evaluated as part of the iHOST (Improving Hospital Opioid Substitution Therapy) research intervention.

Methods
We undertook a deliberative guideline development process. The University London College Hospital (UCLH) substance dependence guideline was used as a template, with key points of revision informed by evidence review, consultations with hospital staff and people with opioid dependence. A multidisciplinary working group deliberated evidence statements to develop recommendations. These were reviewed by an oversight committee comprising representatives from key stakeholder organisations. The team authored the guideline with iterative review by the oversight committee, key stakeholders and UCLH clinical governance committees.

Results
Deliberation focused on three key domains: (1) identifying opioid dependence and promptly continuing existing OST prescriptions; (2) initiating or re-titrating OST; (3) ensuring safety and continuity of care at discharge. Changes to the UCLH guideline included removal of mandatory urine drug testing prior to OST; increasing initial methadone titration dose; and provision for a higher day-one titration dose when specific safety criteria are met. A new titration schedule for sublingual buprenorphine was incorporated. Discharge planning to ensure continuity of community care and reduce risk of opioid overdose was emphasised, with allowance for bridging prescriptions of OST and naloxone provision on hospital discharge.

Conclusion
The iHOST clinical guideline aims to remove procedural barriers to opioid withdrawal management for hospital inpatients. It is intended to be implemented by other NHS hospitals, which could improve access to OST and reduce discrepancies in treatment access and completion.

Study registration
ISRCTN47320412 https://doi.org/10.1186/ISRCTN47320412.
First-in-human trial using mixed-reality visualization for patient setup during breast or chest wall radiotherapy
Authors: Johnson Perry B. , Bradley Julie , Lampotang Samsun , Jackson Amanda , Lizdas David , Johnson William , Brooks Eric , Vega Raymond B. Mailhot , Mendenhall Nancy 
Published: November 2024

Abstract
Background
The purpose of this study is to assess the feasibility of mixed-reality (MixR) visualization for patient setup in breast and chest wall radiotherapy (RT) by performing a first-in-human clinical trial comparing MixR with a 3-point alignment.

Methods
IRB approval was granted for a study incorporating MixR during the setup process for patients undergoing proton (n = 10) or photon (n = 8) RT to the breast or chest wall. For each patient, MixR was utilized for five fractions and compared against another five fractions using 3-point alignment. During fractions with MixR, the patient was aligned by at least one therapist wearing a HoloLens 2 device who was able to guide the process by simultaneously and directly viewing the patient and a hologram of the patient’s surface derived from their simulation CT scan. Alignment accuracy was quantified with cone-beam CT (CBCT) for photon treatments and CBCT plus kV/kV imaging for proton treatments. Registration time was tracked throughout the setup process as well as the amount of image guidance (IGRT) utilized for final alignment.

Results
In the proton cohort, the mean 3D shift was 0.96 cm using 3-point alignment and 1.18 cm using MixR. An equivalence test indicated that the difference in registration accuracy between the two techniques was less than 0.5 cm. In the photon cohort, the mean 3D shift was 1.18 cm using 3-point alignment and 1.00 cm using MixR. An equivalence test indicated that the difference in registration accuracy was less than 0.3 cm. Minor differences were seen in registration time and the amount of IGRT utilization.

Conclusions
MixR for patient setup for breast cancer RT is possible at the level of accuracy and efficiency provided by a 3-point alignment. Further developments in marker tracking, feedback, and a better understanding of the perceptual challenges of MixR are needed to achieve a similar level of accuracy as provided by modern surface-guided radiotherapy (SGRT) systems.

Trial registration
ClinicalTrials.gov, UFHPTI 2015-BR05: Improving Breast Radiotherapy Setup and Delivery Using Mixed-Reality Visualization, NCT05178927.