bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association of Q472H variant in the KDR gene with recurrent pregnancy loss in Southern Iran: A case-control study
Authors: Keshavarz Leila , Yavarian Majid 
Published: August 2019

Background: Recurrent spontaneous abortion (RSA) often remains unclear and can be burden for the patient and time consuming for clinician. RSA may initiates from a genetic or non-genetic factors. It is well known that the quality of placental circulation is critical for implantation and embryo development. Because of angiogenic effects of VEGF–KDR pathway on placenta, the genes involved in this pathway (the KDR or VEGFR genes) are thought to be linked with RSA.
Objective: The aim of this study was to investigate the relationship between Gln472His (A/T) polymorphism of the KDR gene with RSAs in southern Iran.
Materials and Methods: In this case-control study, 50 aborted embryonic tissue obtained from fetuses and 50 umbilical cord blood of newborn babies were studied. Fetal sample from mothers with history of at least two consecutive miscarriages and controls from mothers who had at least one full-term infants born were taken. Genomic DNA was extracted by using PureLink genomic DNA kit (Life Technologies, CA). The Rotor-Gene Q real-Time PCR machine and High-resolution melting curve analysis (HRM) technique were used for genotyping.
Results: Based on the AA genotype as reference, it is shown that the T allele (OR = 2.447, 95% CI = 1.095–5.468, p = 0.029) as well as AT heterozygote genotype was significantly associated with an increased risk of miscarriage (OR = 2.824, 95% CI = 1.210-6.673, p = 0.016).
Conclusion: A positive correlation between Q472H polymorphism of the KDR gene and RSA may be the cause in southern Iran.
Stevia rebaudiana Bertoni Leaves Extract as a Nutraceutical with Hypoglycemic Activity in Diabetic Rats
Authors: Lestari Keri , Ridho Abdurahman , Nurcayani Nuning , Ramadhania Zelika Mega , Barliana Melisa Intan 
Published: August 2019

BACKGROUND: The prevalence of diabetes mellitus is growing every year, including in Indonesia. Medicinal herbs were used empirically for lowering blood glucose. One of potential herb to have hypoglycemic activity is Stevia. Stevia rebaudiana Bertoni leaves contain stevoside, a natural, low-calorie sweetener that is 300 times sweeter than saccharose. In this study, we aimed to explore the hypoglycemic activity of S. rebaudiana Bertoni leaves extract in a rat model of type 2 diabetes mellitus (T2DM). METHODS: Male Wistar rats were feed high-fat, high-carbohydrate feed and sugar solution for 74 days to induce a diabetic rat model. The animals were then divided into five groups consisting of a negative control group treated with 2% Pulvis Gom Arabicum; a positive control group treated with Metformin 45 mg/kg body weight (BW); and three test groups treated with aqueous extract of S. rebaudiana Bertoni leaves at doses of 3.125, 6.25 and 12.5 mg/kg BW for 36 days. Blood glucose was measured on days 14, 28 and 36.RESULTS: The results showed that blood glucose levels over 36 days were significantly (p=0.043) lower in the group treated with S. rebaudiana Bertoni leaves extract. Further Newman-Keuls analysis suggested that the hypoglycemic activity of S. rebaudiana Bertoni leaves extract was dose-dependent. CONCLUSION: Our results indicate that S. rebaudiana Bertoni leaves extract has a potential role as a hypoglycemic agent in the treatment of T2DM.KEYWORDS: Stevia rebaudiana Bertoni, nutraceuticals, hypoglycemic, diabetic rats
BUKTI-BUKTI PROSES ISLAMISASI DI KESULTANAN PALEMBANG
Authors: Rochmiatun Endang 
Published: August 2019

When is Islam into Palembang is not surely, without else still conflict, because any more arguments. Distribution of Islam in Palembang can do it the way of the peace, and then continues step by step. Islamisasi process can do it tool, like as economic of way, married of the way and tassawuf. more than factually Islam into Palembang, so that signed like as mosque, grave, town center and then manuscript.

Key word: Kapan Islam Masuk di Palembang, Proses Islamisasi, Bukti Islam di Palembang
Development of Interactive Multimedia on The Subject of the Nervous System for Students Grade XI of Senior High School
Authors: Farkhah Siti Nailatul , Subchan Wachju , Iqbal Mochammad 
Published: August 2019

This research aimed at determining the validity of interactive multimedia on the nerve system material that had been developed and finding out the students’ response to the interactive multimedia. This was a developmental research (Research and Development) followed by a small group test on the eleventh-grade students of SMAN Ambulu totaling 9 students. The students were selected based on their ability level; 3 students with high ability level, 3 students with moderate ability level and 3 students with low ability level. The data collection techniques used were experts' validation sheets and questionnaires. The design of the interactive multimedia in this research was 4D (define, design, develop and disseminate) model developed by Thiagarajan (1974). The developmental procedure of 4D consists of 4 stages: (1) define, (2) design, (3) develop and (4) disseminate. The results showed that the validity of the developed interactive multimedia reached 82.9% according to the content expert, 86.3% based on the learning expert, 88,3% based on the learning media expert, and 82.7% based on the teacher’s (user) perspective. The results of small group test revealed that the legibility and the level of difficulty were 81.99% or in the good category, and student response score was 83.55%, it means that student had positive response toward the use of developed media in their learning.

Keywords: interactive multimedia, 4D, expert validity.
The Implementation of Demonstration Method to Increase Learning Interest and Outcomes of the Second Grader As-Shakireen School, Thailand
Authors: Fikri Kamalia , Wardani Reta Kusuma , . Ulyanada 
Published: August 2019

This study aimed to increase the interest and learning outcomes of English through Demonstration Method in class II students of As-Shakireen Primary School, Thailand. This research was a classroom action research. Data collection techniques were carried out by means of observation, interest scale, and tests. Data analysis techniques were carried out by means of qualitative and quantitative descriptive. Increased interest and English learning outcomes with Demonstration methods carried out from pre-cycle activities, cycle 1 consisting of stages of planning, acting, observation, and reflection. Based on the results of data analysis, it showed the scale of student interest from pre-cycle to cycle with the use of demonstration method has increased. While student learning outcomes also experience an increase as indicated by the average value of students and the average students who exceed the minimum criteria. So that the demonstration method implemented can increase the interest and learning outcomes of class II students in English subjects at As-Shakireen primary school.

Keywords: demonstration method, learning interest, learning outcomes
STRATEGI PEMBELAJARAN DENGAN MODEL PENDEKATAN PADA PESERTA DIDIK AGAR TERCAPAINYA TUJUAN PENDIDIKAN DI ERA GLOBALISASI
Authors: Anggraeni Novita Eka 
Published: August 2019

Abstrak
Strategi dalam suatu pembelajaran terhadap peserta didik harus tepat kita perlu adanya pendekatan terhadap peserta didik agar kita dapat mengetahui setiap karakter anak, agar kita mudah untuk menentukan suatu model pembelajaran apa yang cocok untuk peserta didik yang akan di didik. Metode ini untuk mempermudah tenaga pendidik juga untuk tidak seenak memberikan model pembelajaran tanpa adanya pendekatan dan akan berakibat pada peserta didik jika kita salah memberi strategi.

Kata Kunci: Strategi pembelajaran, pendekatan pembelajaran, metode pembelajaran
STUDI LITERATURE KESULITAN SISWA SMP/MTs DIPONEGORO WULUHAN DALAM PEMBELAJARAN MATA PELAJARAN BAHASA INGGRIS
Authors: Sholehah Lamatsil Imroatus 
Published: August 2019

Abstract
Learning difficulty is a condition where students experience learning disruptions as they should, both from internal and external factors. This results in students not being able to develop according to their capacity. From this research can be put forward the formulation of the problem, namely, the types of learning difficulties experienced by junior high school / junior high school students in North Sumatra, what factors that make students difficult to learn in English, and how can efforts solve the problem of student learning difficulties. The purpose of this study was to determine the types of difficulties in understanding completing the material in English subjects, the factors that influence students in understanding completing the material in English subjects and problem solving efforts. The method used in this study is to use qualitative methods. Data collection techniques used were literature studies and interviews with each student were different classes. The results of this study are that there are still some students who still have difficulty in understanding completing the material in English subjects from the aspects of listening, reading, structure, and writing, and which are the factors causing students to experience learning difficulties, namely from cognitive factors (ability to memorize , the ability to master the material and the wrong learning habits, and what efforts will be used by educators using teaching repairs.

Keywords: learning difficulties, students, English.
Frequency of Metabolic Syndrome on Diabetes Mellitus Patients in Surabaya
Authors: Puspitasari Dyah Peni , Widodo Budi , Prayitno Jongky Hendro 
Published: August 2019

Backgrounds: Metabolic syndrome is a syndrome characterized by central obesity, high blood glucose or impaired glucose tolerance, dyslipidemia, and high blood pressure. Nearly 70% to 80% of Diabetes melitus (DM) population was diagnosed with metabolic syndrome. We aimed to present the data of frequency of metabolic syndrome in patients with DM for a basis of future research.Method: This is a descriptive study design on DM patients based on NCEP ATP III criteria. The data was collected from direct measurements and laboratory results of all DM patients: waist circumference, weight, height, and blood pressure of the subjects, triglyceride status (TG), high-density lipoprotein cholesterol (HDL-C) status, and fasting blood glucose status.Results: From 77 DM patients, results were obtained in this study were 69 (89.61%) patients with DM-metabolic syndrome (DM-MetS) and 8 (10.39%) patients with DM-non-metabolic syndrome. From 69 patients with DM-MetS, 52 (75.36%) were female and 17 (24.64%) were male.Discussions: Based on NCEP ATP III criteria, the components profile of metabolic syndrome in women patients with DM-MetS were 96,15% central obesity, 88,46% hypertension, 70,37% low HDL levels and 44,44% hypertriglycerides. While, in men patients with DM-MetS were 70.59% central obesity, 88.24% in hypertension, 70% in the low HDL levels, and 30% hypertriglycerides. Based on the number of components, can be determined the frequency components of the metabolic syndrome were 73.91% on the three components, 14.49% on four components, and 11.59% at five components.Conclusion: A total of 69 (89.61%) patients with T2DM were diagnosed as metabolic syndrome.
Correlation Between Nutritional Status Of Children Aged 12 – 36 Months And Mother’s Working Status In Taman, Sidoarjo
Authors: Nugraheningtyasari Nur Annisa , Soemayarso Ninik Asmaningsih , Susanti Dwi 
Published: August 2019

Introduction: The correlation between child’s nutritional status and mother’s working status in Indonesia is still unclear. Some research report a high prevalence of low-nourished children whose mother is working, while others report a non significant correlation between child’s nutritional status and mother’s working status.Methods: This study was case-control study, sample of low-nourished children (treatment group) & well-nourished children (control) are taken from 21 Posyandu in Taman, Sidoarjo in 2015. All data were analyzed using Chi Square test.Results: There are 72 samples which are suitable with the inclusion criteria, consisted of 36 low-nourished children and 36 well-nourished children. From 72 samples, 28 children have a working mother and 44 children have a non working mother. There were no correlation between Mother’s working status (p=0,486), Number of children in the family (p=0,468), History of chronic disease (p=0,054) with child’s nutritional status. Level of family income, Mother’s education level, History of exclusive breastfeeding, Energy consumption level, Protein consumption level were correlated with child’s nutritional status with value (p=0,000), (p=0,002), (p=0,002), (p=0,000), (p=0,001) respectively.Conclusion: Mother’s working status is proved that is not correlated with child’s nutritional status. But, level of family income, mother’s education level, energy & protein consumption level, and history of exclusive breastfeeding are significantly correlated with child’s nutritional status.
Profile of Acute Pharyngitis at Dr. Soetomo General Hospital Pediatric Outpatients Clinic in 2013
Authors: Trilana Amanda , Susanti Dwi , Boediman Satrio 
Published: August 2019

Introduction: Acute Pharyngitis remains a common health problem in the world, especially in developing countries andmostly infects children. Around 6,2 to 9,7 million children worldwide went to clinics and emergency department with pharyngitis. This study aims to find the characteristic of acute pharyngitis in childen at Dr. Soetomo Hospital Surabaya.Methods: This study was a cross sectional, using medical records of acute pharyngitis patients in pediatric outpatient clinic. Data collected based on age, sex, chief complaint, additional complaints and clinical signs.Results: Total samples were 92 patients with sex proportion of 48 males (52,2%) and 44 females (47,8%). Based on age, mostly at 0 – 3 years old (68,4%). The most common chief complains were fever, followed by cough and sore throat for 55,4%, 28,2% and 16,4% respectively. Based on additional complain, 56,5% still has good appetite. Based on clinical signs, hyperemic pharyngeal was 91,3% and lymph nodes enlargement was 8,7%.Conclusion: Acute pharyngitis mostly infected toddler characterized with fever, and hyperemic pharyngeal as a clinical sign.
THE EFFORTS TO INCREASE KNOWLEDGE ABOUT BALANCED NUTRITION AT ELEMENTARY SCHOOL CHILDREN
Authors: Damayanti Ratih , Lutfiya Indah , Nilamsari Neffrety 
Published: August 2019

Background: The balanced nutrition paradigm is currently unknown to the general public, especially school-age children. The old paradigm of four healthy five perfects is still taught in schools. Whereas in the new paradigm of balanced nutrition, in addition to the principle of nutrition that must be consumed in a balanced manner, there is another message that must be conveyed, namely physical activity at least 30 minutes every day, regular exercise, drinking 8 glasses of water a day, washing hands before and after eating and always monitor your weight. Purpose: This community service activity aims to improve balanced nutrition knowledge in elementary school age children. Method: The method of community service is through lectures and games for ice breaking so that the atmosphere becomes more fun. Results: Most of the students of SDN Kalisari 1 Surabaya were female (54%), 10 years old (62%), and parents had jobs in the “other” category namely construction workers, janitors and farm workers (38%). As many as 83% of students have breakfast habits and 88% of students often access the internet. The level of student’s knowledge of balanced nutrition is included in the sufficient category (59%). There is a difference in the level of knowledge before and after counseling about the concept of balanced nutrition (α = 0.04). Conclusion: Efforts to increase knowledge of balanced nutrition with counseling and game methods are considered effective because there is a significant increase in the level of knowledge of SDN Kalisari 1 Surabaya students.
Rotational Osteotomy of the Humeral Shaft for Malunion in Osteogenesis Imperfecta
Authors: Nicholson Thema A. , Elder Alexandra , Gallen Kate , Namdari Surena 
Published: August 2019

Case:
We report a case of an adult with osteogenesis imperfecta, who underwent humeral shaft osteotomy to correct an internal rotation deformity results from a humeral shaft malunion. The patient incurred a temporary radial nerve palsy.

Conclusions:
Humeral shaft malunion can be successfully treated with rotational osteotomy of the humerus through an anterior approach; however, the risk of radial nerve palsy exists and may be minimized by a posterior approach.
Duration of Hormonal Contraception and Risk of Cervical Cancer
Authors: Kusmiyati Yuni , Prasistyami Annisaputri , Wahyuningsih Heni Puji , Widyasih Hesty , Adnani Qorinah Estiningtyas Sakilah 
Published: August 2019

The use of long hormonal contraceptives can disrupt the balance of estrogen in the body, resulting in abnormal cell changes. This study aimed to determine a correlation between the duration of hormonal contraception and risk of cervical cancer. This study used a case-control design. The population were patients who had examined at a cancer installation and obstetrics-gynecology polyclinic Dr. Sardjito Hospital in 2018. Case samples were 95 women have cervical cancer diagnosis and control were 95 women with a negative pap smear. Sampling with random sampling. Dependent variable cervical cancer and independent variable the duration of hormonal contraception are obtained from medical records. Cervical cancer is assessed by doctor’s diagnosis. Data analysis used logistic regression. Results showed that 44.7% of samples used long-term hormonal contraception (over 5 years). Length of use of hormonal contraception had a significant correlation with the incidence of cervical cancer (p-value < 0.01). Hormonal contraceptive use more than 5 years have a risk 4.2 times (95% CI 1.01-5.69) of cervical cancer than using less than 5 years after being controlled with the first marriage age and parity
Value of clinical examination in the assessment of penetrating neck injuries: a retrospective study of diagnostic accuracy test
Authors: Isaza-Restrepo Andres , Contreras Julián Andrés Quintero , Escobar-DiazGranados Jorge , Ruiz-Sternberg Ángela María 
Published: August 2019

Abstract
Background: There are many high-volume trauma centers in limited resource environments where a thorough clinical examination of patients may contribute to a more economic, accurate, and widely applicable method of determining the proper management of patients with penetrating neck injuries. The purpose of this study was to validate thorough physical examination as a reliable diagnostic tool in these patients.

Methods: We performed an observational retrospective study of a diagnostic accuracy test where we compared clinical findings (symptoms and soft signs on admission of the patient) with the definitive findings according to the gold standard test for each particular situation (selective studies, clinical observation and surgical exploration). The study was conducted at Hospital Occidente Kennedy (HOK) between August 2009 and June 2010.

Results: The sample consisted of the clinical records of 207 (n=207) patients who went to the emergency room for penetrating neck wounds at Hospital Occidente Kennedy (HOK) . Of the total sample, 36.2% (n=75) of patients were considered “asymptomatic” as they didn’t present with any soft signs of injury. Vascular soft signs were present in 57% (n=118) of the patients, soft signs of the airway and the upper gastrointestinal tract were present in 15.9% (n=33) and 21.3% (n=44) of the patients respectively. The sensitivity and negative predictive value (NPV) of any soft sign to determine injuries which require surgical repair was 97.4% [CI] [86.5%-99.5%] and 98.7% [CI] [92.8%-99.8%] respectively, with a range of confidence [CI] of 95%.

Conclusions: Our study´s main findings suggest that patients with neck injuries and no vascular, airway, or gastrointestinal soft sign can be safely managed with a conservative approach. It is important to emphasize the value of the clinical examination since there are many contexts in the modern world where a considerable amount of the population is afflicted by neck trauma and treated under conditions where technological resources are limited.
Do virtual renal clinics improve access to kidney care? an impact evaluation of a virtual clinic in east London
Authors: Hull Sally Ann , Rajabzadeh Vian , Thomas Nicola , Hoong Sec , Dreyer Gavin , Rainey Helen , Ashman Neil 
Published: August 2019

Abstract
BACKGROUND

Evidence from the UK national chronic kidney disease (CKD) audit, identifies deficits in the identification and management of CKD within primary care. Aligning the requirement of GPs for a responsive nephrology service, with the capacity of renal services and the need to prioritise patients with progressive disease requires a re-think of traditional models of care. Utilising the health data in the primary care electronic health record (EHR) to bridge the primary secondary divide is one way forward.

METHODS

We describe a novel community kidney service based in the renal department at Barts Health NHS Trust and four clinical commissioning groups (CCGs) in east London. An impact evaluation of the changes in service delivery used quantitative data from the virtual CKD clinic and from the primary care electronic health records (EHR) of 166 participating practices. Survey and interview data from health professionals were used to explore changes to working practices.

RESULTS

Analysis of the virtual clinic data shows a rapid rise in referrals. The majority (>80%) do not require a traditional face to face appointment but can be managed with advice to the referring clinician. The wait for a nephrology opinion fell from 64 to 5 days. The age adjusted referral rate was 2.5 per 1000 registered patients. Primary care clinicians expressed positive views including the rapid response to clinical queries, increased confidence in CKD management, improved access for patients unable to travel to clinic, and reported patient satisfaction. Nephrologists valued seeing the entire clinical record which improved clinical advice, but had concerns about the volume of referrals and changes to working practices.

CONCLUSIONS

It is feasible to develop ‘virtual’ specialist services using shared access to the primary care EHR. Such services expand capacity to deliver timely advice based on a review of the entire EHR. To use both specialist and generalist expertise efficiently such services are best supported by community interventions which engage primary care clinicians in a data driven programme of service improvement.