bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unethical, neurotic, or both? A psychoanalytic account of ethical failures within organizations
Authors: de Colle Simone , Freeman R. Edward 
Published: August 2019

AbstractThis paper aims to integrate insights from psychoanalytic theory into business ethics research on the sources of ethical failures within organizations. We particularly draw from the analysis of sources and outcomes of neurotic processes that are part of human development, as described by the psychoanalyst Karen Horney and more recently by Manfred Kets de Vries; we interpret their insights from a stakeholder theory perspective. Business ethics research seems to have overlooked how “neurotic management styles” could be the antecedents of unethical behavior within organizations. After showing the connection between five managerial neuroses and the corresponding potential ethical failures within organizations that have been already identified within business ethics research, we suggest three organizational strategies to counteract these failures. First, we argue that managers should pay greater attention at the complexity of human motivation, avoiding the simplistic view of compliance‐based approaches. Second, we discuss the importance of developing a conversation around values within organizations, enabling healthy individual growth and limiting the emergence of neurotic processes. Finally, we discuss the role of the business ethicist in facilitating such a process, suggesting a parallel between the role of the business ethicist and that of the psychoanalytic therapist.
Deciding with dignity: The account of human dignity as an attitude and its implications for assisted suicide
Authors: Weber‐Guskar Eva 
Published: August 2019

AbstractDiscussions about assisted suicide have hitherto been based on accounts of dignity conceived only as an inherent value or as a status; accounts of dignity in which it appears as a (contingent) attitude, by contrast, have been neglected. Yet there are two good reasons to consider dignity to be an attitude. First, this concept of dignity best allows us to grasp a crucial aspect of everyday language: people often express fears of losing their dignity—and it is not possible to explain this with an account in which dignity is inherent. Second, such a concept allows us to adduce new argumentation where the argument based on status ends. Dignity considered as a status provides grounds to argue for the moral permissibility of assisted suicide, in the sense that in such an account individuals possess the normative power to waive their right to life. But the question then remains of how to decide what counts as a good reason for assisted suicide—and this is where an argument based on dignity as an attitude can provide illumination.
Neuroimmune interactions: how the nervous and immune systems influence each other
Authors: Taams L S 
Published: August 2019

Summary
In recent years, researchers worldwide have expanded our understanding of how, and the degree to which, the immune system interacts with the nervous system, and vice versa. In this issue of Clinical & Experimental Immunology, we are pleased to present our new Review Series: ‘Neuroimmune interactions: how the nervous and immune systems influence each other’, a collection of four Review articles commissioned by Leonie S. Taams from leading researchers in this exciting interdisciplinary field. The collection covers key technical, experimental and clinical findings in the fast-developing field of neuroimmunology.
Patient satisfaction and oral health‐related quality of life (OHRQoL) of conventional denture, fixed prosthesis and milled bar overdenture for All‐on‐4 implant rehabilitation. A crossover study
Authors: ELsyad Moustafa Abdou , Elgamal Mohamed , Mohammed Askar Osama , Youssef Al‐Tonbary Gilan 
Published: August 2019

AbstractObjectivesThis study aimed to evaluate patient satisfaction and oral health‐related quality of life (OHRQoL) of conventional denture, fixed prosthesis and milled bar overdenture for All‐on‐4 implant rehabilitation.Materials and methodsSixteen completely edentulous patients with ill‐fitted mandibular dentures received new mandibular dentures (CDs). After 3 months, 4 implants were installed according to the “All‐on‐4 concept” and immediately loaded with mandibular dentures. Three months after osseointegration, patients received either fixed prosthesis (FP) or milled bar overdenture (MB) in a crossover design. Patient satisfaction was evaluated using a visual analog scale (VAS). OHRQoL was evaluated using the OHIP‐14. Questionnaires of VAS and OHIP‐14 were measured 3 months after wearing each of the following prostheses: CD, FP, and MB.ResultsFor all questions of VAS and OHIP‐14, CD showed significant lower satisfaction compared to FP and MB (p < .00025). FP recorded significant higher VAS scores than MB regarding retention and stability (p < .00007). MB recorded significant higher scores than FP regarding general satisfaction, comfort, ease of cleaning, and handling (p < .00008). Regarding OHIP‐14, no significant differences in OHIP scores between FP and MB were observed for all domains of OHIP.Conclusion“All‐on‐4” implant rehabilitation of edentulous mandible with FP and MB achieves high patient satisfaction and OHRQoL compared to CD. No significant difference in OHRQoL between FP and MB was observed. Regarding VAS, FP rated greater satisfaction with retention, stability, and chewing compared to MB. However, MB rated greater satisfaction with ease of cleaning and handling compared to FP.
D‐Ser2‐oxyntomodulin ameliorated Aβ31‐35‐induced circadian rhythm disorder in mice
Authors: Wang Li , Zhao Jin , Wang Chang‐Tu , Hou Xiao‐Hong , Ning Na , Sun Cong , Guo Shuai , Yuan Yuan , Li Lin , Hölscher Christian , Wang Xiao‐Hui 
Published: August 2019

AbstractIntroductionThe occurrence of circadian rhythm disorder in patients with Alzheimer's disease (AD) is closely related to the abnormal deposition of amyloid‐β (Aβ), and d‐Ser2‐oxyntomodulin (Oxy) is a protease‐resistant oxyntomodulin analogue that has been shown to exert neuroprotective effects.AimsThis study aimed to explore whether Oxy, a new GLP‐1R/GCGR dual receptor agonist, can improve the Aβ‐induced disrupted circadian rhythm and the role of GLP‐1R.MethodsA mouse wheel‐running experiment was performed to explore the circadian rhythm, and western blotting and real‐time PCR were performed to assess the expression of the circadian clock genes Bmal1 and Per2. Furthermore, a lentivirus encoding an shGLP‐1R‐GFP‐PURO was used to interfere with GLP‐1R gene expression and so explore the role of GLP‐1R.ResultsThe present study has confirmed that Oxy could restore Aβ31‐35‐induced circadian rhythm disorders and improve the abnormal expression of Bmal1 and Per2. After interfering the GLP‐1R gene, we found that Oxy could not improve the Aβ31‐35‐induced circadian rhythm disorder and abnormal expression of clock genes.ConclusionThis study demonstrated that Oxy could improve Aβ31‐35‐induced circadian rhythm disorders, and GLP‐1R plays a critical role. This study thus describes a novel target that may be potentially used in the treatment of AD.
Temperature and prey density jointly influence trophic and non‐trophic interactions in multiple predator communities
Authors: Veselý Lukáš , Boukal David S. , Buřič Miloš , Kuklina Irina , Fořt Martin , Yazicioglu Buket , Prchal Martin , Kozák Pavel , Kouba Antonín , Sentis Arnaud 
Published: August 2019

AbstractEnvironmental changes such as global warming can affect ecological communities by altering individual life histories and species interactions. Recent studies focusing on the consequences of environmental change on species interactions highlighted the need for a wider, multi‐species context including both trophic and non‐trophic interactions (e.g. predator interference). However, the effects of biotic and abiotic factors on trophic and non‐trophic interactions remain largely unexplored.To fill this gap, we combined laboratory experiments and functional response modelling to investigate how temperature and prey density influence trophic and non‐trophic interactions in multiple predator communities.The system under study consisted of predatory dragonfly larvae (Aeshna cyanea) and omnivorous marbled crayfish (Procambarus virginalis) preying on common carp fry (Cyprinus carpio). We estimated the functional response of each predator in single‐predator experiments and used this information to disentangle the trophic and non‐trophic interactions and their dependence on environmental conditions in multiple predator trials.We found that consumer identity, prey density, and temperature all affect the magnitude of trophic and non‐trophic interactions. Non‐trophic interactions mostly decreased predator feeding rates, corroborating previous observations that interference prevails in aquatic communities. Moreover, trophic interactions depended primarily on the environmental variables whereas non‐trophic interactions depended mainly on consumer identity.Our results indicate that non‐trophic interactions among true predators and omnivores can be substantial and that biotic and abiotic conditions further modify the magnitude and direction of these interactions, which can affect food web dynamics and stability.
Capital adjustment cost and inconsistency in income-based dynamic panel models with fixed effects
Authors: Basu Parantap , Getachew Yoseph , Bhattarai Keshab 
Published: August 2019

Abstract
After the seminal work of Nickell (1981), a vast literature demonstrates the inconsistency of ‘conditional convergence’ estimator in income-based dynamic panel models with fixed effects when the time horizon (T) is short but the sample of countries (N) is large. Less attention is given to the economic root of inconsistency of the fixed effects estimator when T is also large. Using a variant of the Ramsey growth model with long-run adjustment cost of capital, we demonstrate that the fixed effects estimator of such models could be inconsistent when T is large. This inconsistency arises because of the long-run adjustment cost of capital which gives rise to a negative moving average coefficient in the error term. Income convergence will be thus overestimated. We theoretically characterize the order of this inconsistency. Our Monte Carlo simulation demonstrates that the size of the bias is substantial and it is greater in economies with higher capital adjustment costs. We show that the use of instrumental variables that take into account the presence of the negative moving average term in the error will overcome this bias.
Lights on the shadows of public procurement: Transparency as an antidote to corruption
Authors: Bauhr Monika , Czibik Ágnes , de Fine Licht Jenny , Fazekas Mihály 
Published: August 2019

AbstractThe increased focus on marketizing mechanisms and contracting‐out operations following the New Public Management reform agenda has sparked a debate on whether the close interactions between public and private actors might drive corruption in the public sector. The main response to those worries has been increased transparency, but so far empirical evidence of its efficiency remains scant and mixed. This article argues that the beneficial effects of transparency on corruption are contingent on type of transparency, and in particular, who the intended receiver of the information is. Drawing on newly collected data of more than 3.5 million government contracts between 2006 and 2015, the analysis shows that overall tender transparency reduces corruption risks substantially, yet that the effect is largely driven by ex ante transparency, that is, transparency that allows for horizontal monitoring by insiders in the bidding process.
Helicobacter pylori eradication rates with concomitant and tailored therapy based on 23S rRNA point mutation: A multicenter randomized controlled trial
Authors: Ong Sungmoon , Kim Sung Eun , Kim Ji Hyun , Yi Nam Hee , Kim Tae Young , Jung Kyoungwon , Park Moo In , Jung Hwoon‐Yong 
Published: August 2019

AbstractBackgroundWe evaluated the efficacy of tailored therapy based on point mutation presence identified with the dual‐priming oligonucleotide (DPO)‐based multiplex polymerase chain reaction (PCR) method compared with concomitant therapy.Materials and methodsSubjects were randomly assigned concomitant therapy (amoxicillin 1 g, clarithromycin 500 mg, metronidazole 500 mg, and lansoprazole 30 mg twice/day for 14 days) or tailored therapy (amoxicillin 1 g, clarithromycin 500 mg, and lansoprazole 30 mg twice/day for 14 days in point mutation‐negative subjects; and amoxicillin 1 g, metronidazole 500 mg, and lansoprazole 30 mg twice/day for 14 days in point mutation‐positive subjects).ResultsA total of 397 and 352 subjects were included in the intention‐to‐treat (ITT) and per‐protocol (PP) analyses, respectively. Point mutations were identified in 25.9% of the subjects. The overall eradication rate was not significantly different between the groups by ITT (86.2% vs 81.6%, P = .132) and PP analyses (90.2% vs 86.5%, P = .179). There was no significant difference in the eradication rates between the groups in both the point mutation‐negative subjects (91.7% vs 87.3%, P = .154) and the point mutation‐positive subjects (71.2% vs 64.7%, P = .312). The eradication rates were significantly lower in the point mutation‐positive subjects than in the point mutation‐negative subjects in both the concomitant and tailored therapy groups.ConclusionsTailored therapy based on point mutation presence identified with the DPO‐based multiplex PCR method was as effective as concomitant therapy. The eradication rates of both therapy regimens were suboptimal in point mutation‐positive subjects.
Anal fistula and pilonidal sinus disease coexisting simultaneously: An audit in a cohort of 1284 patients
Authors: Garg Pankaj 
Published: August 2019

AbstractFistula‐in‐ano and pilonidal disease are not known to occur together. In a retrospective study, all patients having fistula‐pilonidal disease coexisting simultaneously were included. Out of 1284 patients, 933 were operated (fistula‐in‐ano, 849; pilonidal disease, 77; and coexisting fistula‐pilonidal, 7). A total of 351 patients did not undergo any surgery (two patients had coexisting fistula‐pilonidal). Thus, a total of nine patients having coexisting fistula‐pilonidal sinus were included in the study (mean age 35.8 ± 19.9 years, M/F 7/2). pIn 6/9 patients, the pilonidal tract was communicating with fistula‐in‐ano, and in 3/9 patients, they were not communicating/connected. The connection could be established preoperatively with the help of MRI. In all patients with communicating fistula‐pilonidal sinus (n=6), the fistula was posterior. 6/9 patients had recurrent fistula and all (9/9) had multiple tracts. The fistula was high and complex in 8/9 patients (grade IV‐7, grade V‐1). 4/9 patients tested positive for tuberculosis while one patient was suffering from hidradenitis suppurativa. The latter improved on medical treatment. One patient did not agree for surgery and seven were operated. The disease healed in four patients, the disease did not heal in one patient, and two patients were in the convalescent stage. Anal fistula and pilonidal disease can coexist in a same patient and can even be connected. Such diseases are more complex and have a higher incidence of associated diseases like tuberculosis. Magnetic resonance imaging plays a pivotal role in diagnosis. If the connection is missed, the disease treatment becomes difficult.
Environmental latitudinal gradients and host‐specificity shape Symbiodiniaceae distribution in Red Sea Porites corals
Authors: Terraneo Tullia I. , Fusi Marco , Hume Benjamin C. C. , Arrigoni Roberto , Voolstra Christian R. , Benzoni Francesca , Forsman Zac H. , Berumen Michael L. 
Published: August 2019

AbstractAimThe aim of the study was to assess the diversity of algal symbionts of the family Symbiodiniaceae associated with the coral genus Porites in the Red Sea, and to test for host‐specificity and environmental variables driving biogeographical patterns of algal symbiont distribution.LocationSaudi Arabian Red Sea.TaxonEndosymbiotic dinoflagellates of the family Symbiodiniaceae in association with the reef‐building coral genus Porites.MethodsEighty Porites coral specimens were collected along the Saudi Arabian Red Sea coast. Species boundaries were assessed morphologically and genetically (putative Control Region – mtCR; ITS region – ITS). Community composition of symbiotic dinoflagellates of the family Symbiodiniaceae was also assessed. Using the ITS2 marker with the SymPortal framework, Symbiodiniaceae data at the genus, majority ITS2 sequence and ITS2 type profile were used to assess symbiont diversity and distribution patterns. These were analysed in relation to coral host diversity, geographic location and environmental variables.ResultsAmong the 80 Porites samples, 10 morphologies were identified. These corals were clustered into five lineages (clades I–V) by each of the markers independently. Clades I, II and III each comprised of a single Porites morphology, while clades IV and V contained up to five distinct morphologies. The diversity of Symbiodiniaceae associated with Porites was high and latitudinal differentiation was observed. In particular, a shift from a Cladocopium‐dominated to a Durusdinium‐dominated community was found along the north–south gradient. Symbiont diversity showed the patterns of geographic‐specific association at Symbiodiniaceae genus, majority ITS2 sequence and ITS2 type profile level. Specific associations with host genotypes (but not morphological species) were also recovered when considering Symbiodiniaceae majority ITS2 sequence and ITS2 type profiles.Main conclusionsThis study provides the first large‐scale molecular characterization of Symbiodiniaceae communities associated with Porites corals from the Saudi Arabian Red Sea. The use of intragenomic diversity data enabled the resolution of host‐symbiont specificity and biogeographical patterns of distribution, previously unachievable with the ITS2 marker alone. Finally, correlation among symbiont diversity and Red Sea environmental gradients was documented.
Material flow analysis and material use efficiency of Brazil's mortar and concrete supply chain
Authors: da Costa Reis Daniel , Mack‐Vergara Yazmin , John Vanderley Moacyr 
Published: August 2019

AbstractCementitious materials, mostly concrete and mortar, account for about one‐third of all materials extraction worldwide. Material flow data in this industry are still unsatisfactory, especially related to unused extraction materials, quarry wastes, and water consumption, aspects which usually are not included in environmental analysis studies. The aim of this study is to conduct a material flow analysis (MFA) of the Brazilian concrete and mortar supply chain to quantify material use efficiency (ME) and dematerialization potential. The MFA includes extraction, production, and construction stages for the following indicators: i) unused extraction; ii) quarry waste; iii) water consumption; iv) material wastage; v) raw material consumption; vi) energy carriers; and vii) atmospheric emissions. The results demonstrated that the primary raw material footprint is about 456 million metric tons (Mt) corresponding to a metabolic rate of 2.2 metric tons/capita (t/capita). After including unused extraction, quarry wastes, water consumption, and secondary materials this value increases to 4.1 t/capita corresponding to a total material consumption of 840 Mt. Concrete and mortar can be produced using two routes—mixing on site or industrial mixing. We conclude that the industrial scenario allows for dematerialization by about 8% for concrete and 24% for mortar, by mass; and the average material use efficiency is low, at about 53% for concrete and 34% for mortar.
Environmental and economic impacts of solar‐powered integrated greenhouses
Authors: Hollingsworth Joseph A. , Ravishankar Eshwar , O'Connor Brendan , Johnson Jeremiah X. , DeCarolis Joseph F. 
Published: August 2019

AbstractGreenhouse vegetable production plays a vital role in providing year‐round fresh vegetables to global markets, achieving higher yields, and using less water than open‐field systems, but at the expense of increased energy demand. This study examines the life cycle environmental and economic impacts of integrating semitransparent organic photovoltaics (OPVs) into greenhouse designs. We employ life cycle assessment to analyze six environmental impacts associated with producing greenhouse‐grown tomatoes in a Solar PoweRed INtegrated Greenhouse (SPRING) compared to conventional greenhouses with and without an adjacent solar photovoltaic array, across three distinct locations. The SPRING design produces significant reductions in environmental impacts, particularly in regions with high solar insolation and electricity‐intensive energy demands. For example, in Arizona, global warming potential values for a conventional, adjacent PV and SPRING greenhouse are found to be 3.71, 2.38, and 2.36 kg CO2 eq/kg tomato, respectively. Compared to a conventional greenhouse, the SPRING design may increase life cycle environmental burdens in colder regions because the shading effect of OPV increases heating demands. Our analysis shows that SPRING designs must maintain crop yields at levels similar to conventional greenhouses in order to be economically competitive. Assuming consistent crop yields, uncertainty analysis shows average net present cost of production across Arizona to be $3.43, $3.38, and $3.64 per kg of tomato for the conventional, adjacent PV and SPRING system, respectively.
Clinical factors, diagnostic delay, and residual deficits in chronic inflammatory demyelinating polyradiculoneuropathy
Authors: Bunschoten Carina , Blomkwist‐Markens Patricia H. , Horemans Anja , van Doorn Pieter A. , Jacobs Bart C. 
Published: August 2019

AbstractManagement of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is complicated by the challenging diagnosis, monitoring of disease activity, and treatment response. Real world data about the current practice of care in CIDP are rare, but important to improve clinical guidelines. In this study, we determined the current practice of diagnosis and treatment in relation to the clinical outcome of patients with CIDP in a cross‐sectional study in The Netherlands. All patients registered at the Dutch neuromuscular patient organization and patients at the Erasmus Medical Center were approached. CIDP diagnosis was confirmed by using patient files and expert consensus. The response rate was 137/197 (70%) and the diagnosis CIDP was confirmed in 112 patients. The time from onset of symptoms until CIDP diagnosis was median 5 months and > 12 months in 26% of the patients. Patients with a late diagnosis (>5 months) compared to patients with an early diagnosis (≤5 months) more frequently had another initial diagnosis (P < .001), multifocal abnormalities (P = .011), final diagnosis made in university hospitals (P = .001), and more (residual) complaints, also illustrated via two patient reported, validated clinical outcome measures. Although 97% of patients received treatment, 88% reported (residual) neurological symptoms and deficits. CIDP diagnosis is often delayed, especially in patients with atypical CIDP variants. Diagnostic delay may result in delayed initiation of treatment. A more rapid and accurate diagnosis of CIDP may prevent or at least reduce residual neurological deficits and accompanying disability in CIDP.