bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of detection range of hydrazides of carboxylic acids and 2-acylhydrazinсarbothioamids by HPLC-ECI-MC
Authors: Varynskyi B. О. 
Published: September 2019

Elaboration of control steps of hydrazids and сarbothioamids, raw materials in the synthesis of 1,2,4-triazol-3-yl-thioacetate acids, potential drug substances on research and production stage is an important task. The study of adsorption, distribution, metabolism and excretion of these substances has great importance. The HPLC-MS is the most universal and selective method used in these cases.
The aim of our study was to determine the optimal conditions for mass spectrometric detection of ionization in electrospray in HPLC-MS іzonіcotinohydrazide, furan-2-carbohydrazide, 2-morpholinoacetohydrazide, 2-methoxybenzohydrazide, 2-isonicotinoyl-N-(2-methoxyphenyl)hydrazine-1-carbothioamide, 2-(furan-2-carbonyl)-N-phenylhydrazine-1-carbothioamide, 2-(2-morpholinoacetyl)-N-phenylhydrazine-1-carbothioamide, N-methyl-2-(2-morpholinoacetyl)hydrazine-1-carbothioamide, 2-(2-methoxybenzoyl)hydrazine-1-carbothioamide, precursor substances in the synthesis of salts of 1,2,4-triazol-3-yl-thioacetate acids for 8 synthetic schemes using full factorial design on 3 factors and polynomial regression equations.
Work was carried out using flow injection analysis (the technique of direct sample introduction into the ion source) on a liquid chromatograph Agilent 1260 Infinity HPLC System with a single quadrupole mass spectrometer Agilent 6120.
The optimal conditions of mass spectrometric detection series hydrazides and сarbothioamides for HPLC-ESI-MS on the basis of the calculated maxima polynomial regression functions were obtained. The equation of polynomial regression for the corresponding hydrazides and carbatioamides were suggested. The equations show the dependence of the mass detector signal intensity on three important factors: dryng gas temperature, the fragmentor voltage, the nebulizer pressure. The optimal conditions of mass spectrometric detection choice to maximize the signal detector and thus increase the sensitivity and selectivity of the determinations. It may allow partially separate the signal of these substances from the impurities signal because these conditions have specificity.
Research of medicinal products of the nsaid of the pharmaceutical market in Ukraine for the period 2014–2018
Authors: Iakovlieva L. V. , Titova A. A. 
Published: September 2019

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are groups of different chemical structures of drugs (derivatives of acids) that are widely used in clinical practice. More than three million people in the world take NSAIDs every day.
The aim of the study – аnalysis of the range and target characteristics of nonsteroidal anti-inflammatory drugs in the Ukrainian pharmaceutical market during 2014–2018.
Nonsteroidal anti-inflammatory drugs, presented on the pharmaceutical market of Ukraine for 2014–2017, were selected as research objects. The research used retail prices, according to the «Pharmstandard» system of the «Morion» company.
NSAIDs in Ukraine during 2014–2018 were represented from 302 to 419 TN based on 32 INN. Diclofenac was also represented by the largest number of trade names, due to its distinct efficacy, less toxicity among the most effective drugs and the low cost of domestic generic drugs. Fewer TN than Diclofenac but more than the bulk of NSAIDs in the market were presented by the following INNs – meloxicam, ibuprofen, nimesulide and a combination of glucosamine with chondroitin sulfate.
A large selection of NSAIDs has been identified in the pharmaceutical market of Ukraine. Imported Nonsteroidal anti-inflammatory drugs are more represented. These drugs have a wide range of prices that allow you to optimize your treatment costs. The prices of NSAIDs for researched period had increase. The reason can be in conditions of political and socio-economic crisis in the country
The main optical characteristics of UV-spectra of 5-(adamantane-1-yl)-4R-1,2,4-triazole-3-thiones derivatives
Authors: Odyntsova V. M. 
Published: September 2019

The development of pharmaceutical chemistry confronts molecular spectroscopy the problem of calculating the electronic states, assumptions and explanations of the various properties of complex organic compounds. In recent years, following the basic optical characteristics of the electronic absorption spectra: the wave number of maximum absorption – νmax (in cm-1), the half-width of the absorption bands of – ∆ν1/2 (cm-1), the integral intensity of the absorption band (in l/mol·cm2), the oscillator strength of the electronic transition – f, the matrix element of the transition of electrons – Mik. began widely used. These constants allow you to determine the chromophores in the investigated substances, to establish the probability and the resolution of the electrons’ transition.
Our goal was the calculation and study of the basic optical characteristics of the electronic absorption spectra of 5-(adamantane-1-yl)-4R-1,2,4-triazole-3-thione, namely 5-(adamantane-1-yl)-4-methyl-1,2,4-triazole-3-thione and 5-(adamantane-1-yl)-4-phenyl-1,2,4-triazole-3-thione derivatives.
When deciding about the purity of the compounds we used melting point, thin layer chromatography and the results of elemental analysis. UV spectra of the investigated compounds was measured with a spectrophotometer Specord 200-222U214 (Germany). Elemental analyzer GmbH (Germany) was used for carrying out the elemental analysis.
It is determined that the values of the half-width Δν½ and integrated intensity of the absorption bands (A), the oscillator strength (f) and matrix element of the transition (Mik) can be used as an important constants of 5-(adamantane-1-yl)-4R-1,2,4-triazole-3-thione derivatives for their identification and establishing a deep connection between spectra and structure of the molecule.
For the studied compounds is the most characteristic absorption band in the medium wave spectrum with high values of A and f, which indicate about the permitted and probable transitions of electrons which give rise to the observed maxima.
Based on the study of the basic optical characteristics of the electronic absorption spectra of 5-(adamantane-1-yl)-4R-1,2,4-triazole-3-thione derivatives is found that chromatofor in the studied molecules is the structure of 1,2,4-triazole and substituents (adamantane, methyl and phenyl radicals).
A distinctive feature, namely 5-(adamantane-1-yl)-4-phenyl-1,2,4-triazole-3-thione 5-(adamantane-1-yl)-4-methyl-1,2,4-triazole-3-tion are the values A, f, Mik, which can be used to identify the investigated compounds.
Review of antibacterial and antifungal activity of 1,2,4-triazole derivatives
Authors: Samura Т. О. 
Published: September 2019

Derivatives of 1,2,4-triazole is a very perspective class of heterocyclic compounds which have high therapeutic effectiveness. The main direction of research on these derivatives are antifungal, antiviral, antibacterial, soothing, hypnotic, anticonvulsant, anti-inflammatory and other activities.
The aim was to analyze literature data and generalize recent advances in the study of antimicrobial and antifungal action of 1,2,4-triazole derivatives which can help to create new biologically active substances of this type of activity. Bibliosemantical method, systems thinking and the results of our own research were used in the work.
The results of the literature review of antimicrobial and antifungal activity among new alkyl, aryl and heteryl derivatives of 1,2,4-triazole and among complex compounds, which contain 1,2,4-triazole are as ligands were analyzed and systematized. Some dependence of this type of activity on specialty of chemical structure of heterocyclic system derivatives was specified.
Perspective of purposeful synthesis of new derivatives of 1,2,4-triazole and products of their transformation as available object for studying biological activity and expanding knowledge about antimicrobial and antifungal activity of this class of heterocyclic compounds were shown with informational analysis. Topicality and practical importance of finding biologically active compounds and receiving biologically active substance by synthesis of new derivatives of 1,2,4-triazole with high antimicrobial activity in relation to gram-negative and gram-positive bacteria were demonstrated.
Outcome of laparoscopic appendicectomy for acute appendicitis in tertiary level hospitals
Authors: Biswas Proshanta Kumar , Hossain Syed Mozammel , Faruquzzaman Md 
Published: September 2019

Background: In the very recent years, laparoscopic appendicectomy is widely accepted for the surgical procedure of acute appendicitis. Though the application of laparoscopic technique for appendicectomy is expanding very rapidly and now performed in almost all major cities and tertiary level hospitals in our country, but the reports are scanty and conflicting in our surgical practice.
Objective: This prospective clinical study was conducted to evaluate the outcome of laparoscopic appendicectomy in acute appendicitis in terms of complication, post surgical pain, conversion rate, negative appendicectomy and duration of hospital stay.
Methods: The study was carried out taking a total number of 93 patients of which 53 fulfilled the inclusion criteria admitted in BIRDEM General Hospital, Dhaka and 40 such patients from Khulna Medical College Hospital Khulna and a private clinic in Khulna City during the period from April, 2016 to August, 2018 with the patients of laparoscopic appendicectomy (LA) for acute appendicitis. Data was collected on history and clinical examination, investigation, histopathological examination and post operative complication.
Results: Among total 93 patients, majority of the patients were in age group of 20 to 30 years in both sexes and 65.6% were male and 34.4% were female. In case of 06(6.5%) patients negative appendicectomy were done and in 09(9.7%) patients conversion to open appendicectomy was required. Post operative complications like port site bleeding and infection were 4.3% and 2.1% respectively. Majority (87.10%) patients were discharged within 72 hours of LA.
Conclusion: This study reveals that laparoscopic appendicectomy is a minimally invasive and relatively safe procedure for acute appendicitis.
Bang Med J (Khulna) 2018; 51 : 12-15
DEFESA DOS DIREITOS DAS PESSOAS COM DEFICIÊNCIA: A CONTRIBUIÇÃO DA ATUAÇÃO DO ASSISTENTE SOCIAL DA APAE DE TRÊS CORAÇÕES-MG, FUVAE E DO CONSELHO MUNICIPAL DE DIREITOS DAS PESSOAS COM DEFICIÊNCIA DE VARGINHA-MG
Authors: Mafra Tatiele Divino , Almeida Cleusimar Cardoso Alves , Jacinto Adriana Giaqueto 
Published: September 2019

Este trabalho propõe como objetivo descrever sobre as contribuições da atuação do Assistente Social na Associação de Pais e Amigos dos Excepcionais (APAE) de Três Corações e na Fundação Varginhense de Assistência aos Excepcionais de Minas Gerais (FUVAE), de Varginha, e contribuições do trabalho do Conselho Municipal de Direitos da Pessoa com Deficiência (CODEVA), de Varginha, na viabilização e defesa dos direitos sociais das pessoas com deficiência e seus familiares. Foi realizada pesquisa de campo, com abordagem qualitativa, aplicando questionários e entrevistas semiestruturadas a 20 famílias na APAE Três Corações-MG e na FUVAE de Varginha-MG, roteiro de entrevista para 2 assistentes sociais da FUVAE e com 1 secretária coordenadora da APAE, e entrevistas semiestruturadas com 10 conselheiros e colaboradores do CODEVA, de Varginha. Foi possível identificar que o perfil das famílias das pessoas com deficiência assistidas pela FUVAE e APAE, são famílias de baixa renda e com acesso às informações, principalmente, devido à intervenção do assistente social. As contribuições deste profissional em ambas as Instituições são favoráveis para a socialização das informações e conquistas dos direitos das pessoas com deficiência. A atuação do CODEVA é importante no processo de descentralização, democratização das políticas sociais, participação comunitária e efetivação dos direitos.
REMARQUES SUR LE DIAGNOSTIC EN MATIÈRE PÉNALE
Authors: Stępniak Piotr 
Published: September 2019

L'article est consacré au diagnostic correct en matière pénale. Son auteur analise les problèmes liés au passage de la criminologie universitaire à la pratique de la justice et aux institutions exécutant des décisions judiciaires (service pénitentiaire, agents de probation, etc.).L'auteur indique des difficultés de diagnostic résultant de la complexité de divers facteurs criminogènes, ainsi que de l'impossibilité de les couvrir par un examen approfondi. Leur effet est la faible precisions de la plupart des diagnostics préparés dans la pratique. Cela rend difficile de déterminer une réponse pénale adéquate au crime, en particulier le choix des peines et des mesures pénales appropriées.Cependant, la raison la plus importante de la difficulté à diagnostiquer est le facteur du libre choix de l'homme dans la criminogenèse (homo eligens). Il est visible dans la décision de commettre un crime ou son absence en réponse à une situation spécifique. Ce facteur est très difficile à examiner. L’auteur discute des theses de soi-disant la criminologie humaniste, qui tente d'expliquer le rôle du libre arbitre humain dans la genèse du crime.En conclusion, l'auteur souligne que les tribunaux agissent dans une large mesure de manière schématique. Ils se concentrent sur le nombre le plus grand de décisions et de jugements que possible. Dans la pratique quotidienne, il n’ya pas de temps pour une réflexion intellectuelle approfondie. Il sufit d’appliquer les schémas simplifiés éprouvés et des mêmes outils de diagnostic, d’analyser et d’évaluer les facteurs de risque standard. A la fin d’article son auteur tire la conclusion finale que la criminologie universitaire est utile pour le juge moyen, l'agent de probation ou l’educateur de prison dans une mesure limitée.
Anti-VEGF Therapy In Central Retinal Vein Occlusions
Authors: Rahmah Meidina , Amin Ramzi , Ansyori AK 
Published: September 2019

Introduction: Central retinal vein occlusion (CRVO) is the second most common retinal vascular disease after diabetic retinopathy and is estimated to affect more than 16 million adults worldwide. Treating the underlying cause of occlusion of the central retinal vein, reducing the risk factors, and early and proper management are the keys toward a better prognosis in patients with CRVO. Repeated frequent treatment of CRVO with macular edema with intravitreal anti-vascular endothelial growth factor (anti-VEGF) is an effective treatment to improve visual outcome. In this case report we assess the 3-month efficacy of anti-VEGF therapy in CRVO.
Method: In this case, a 52-year-old man presented with an acute loss of vision over the last week in his left eye. His baseline visual acuity was 1/60 and his central retinal thickness (CRT) on Optical Coherence Tomography (OCT) was 523 μm. Fundus examination revealed a hemorrhage in all four quadrants, hard exudates, swelling of the optic nerve, and macular edema. Laboratory test confirms hyperlipidemia and we consult this patient to Internal Medicine Department. This patient got 3 monthly injections of 1,25 mg Bevacizumab.
Results: By 3 months, the OCT appeared fairly normal and the visual acuity improved to 6/60
Conclusion: Anti-VEGF therapy is effective for treating macular edema secondary to CRVO
The Effect of Citicoline on Electroretinography Abnormalities in Patients with Non-proliferative Diabetic Retinopathy
Authors: Utami Anna Nur , Elvioza Elvioza , Sidik M 
Published: September 2019

Introduction : to determine the effect of citicoline 1000 mg oral supplementation given for 4 weeks on electroretinography abnormalities in patients with NPDR (non-proliferative diabetic retinopathy).
Methods : prospective, double blind, randomized clinical trial. Thirty-eight patients who matched the inclusion and exclusion criteria were randomized into two groups: the placebo (P-NPDR) and citicoline (C-NPDR). In the end, there were 18 eyes in citicoline group and 16 eyes in placebo group. The primary outcome was P50 and N95 amplitude in PERG within group and intergroup which were taken at the baseline and 4 weeks after treatment.
Results : at the end of treatment, the N95 amplitude in C-NPDR showed improvement, 4.85 (1.9-10.3) µV, before treatment to 5.7 (1.9-17.1) µV, after treatment with P = 0.04. Median P50 amplitude improved in both groups, with C-NPDR: 3.1 µV to 3.8 µV (p = 0.89), and P-NPDR: 3.5 µV, to 4.5 µV (p = 0.10). Delta ∆N95 amplitude is higher in C-NPDR, while delta ∆P50 amplitude is higher in P-NPDR, with P values 0.35 and 0.45.
Conclusion : Oral citicoline may induce a significant improvement in mean N95 amplitude before and after the treatment. P-NPDR showed positive trend in P50 amplitude while in C-NPDR showed positive trend in N95 amplitude, but these values were not statistically significant (P = 0.45; P= 0.35).
The Evaluation of Silicon Oil Evacuation Procedure In Cipto Mangunkusumo Hospital Indonesia
Authors: Triwijayanti Triwijayanti , Djatikusumo Ari , Victor Andi Arus , Elvioza Elvioza , Adriono Gitalisa Andayani , Yudantha Anggun Rama , Hutapea Mario Marbungaran 
Published: September 2019

Background: Injection of Silicon oil is a standard procedure for vitreous replacement in vitrectomy procedure for retinal detachment cases. It acts as a great tamponading agent for reattachment of retinal breaks or retinal detachment. Despite its minor side effect, silicon oil could cause several complications such as cataract, endothelia decompensation, increased intraocular pressure, and secondary glaucoma. Thus needed to be evacuated after the retinal reattachment is stabilized. Following evacuation procedure, visual acuity are known to be significantly improved. However, some cases shows decreased of visual acuity due to retinal redetachment, optic nerve damage due to secondary glaucoma, hypotonym vitreous hemorrhage, expulsive hemorrhage, and cornea abnormality.
Methods: A retrospective descriptive study of retinal detachment patients underwent silicon oil evacuation procedure in Cipto Mangunkusumo Hospital, Indonesia from September 2017 until Januari 2018.
Results: There were seventy seven cases of retinal detachment undergoes silicon oil evacuation within period of September 2017-Januari 2018. There were improvement of visual acuity (greater than 6/60) after one month of silicon oil evacuation. Anatomical retinal reattachment was successfully observed in 91% patient. The most occuring complication after silicon oil evacuation includes secondary glaucoma and retinal redetachment.
Conclusion: Silicon oil evacuation is a standard procedure following a vitrectomy in retinal detachment cases. The evacuation procedure yields in positive benefit for patient in term of visual acuity and anatomical structure.
The Degree of Alignment between Circumbinary Disks and Their Binary Hosts
Authors: Czekala Ian , Chiang Eugene , Andrews Sean M. , Jensen Eric L. N. , Torres Guillermo , Wilner David J. , Stassun Keivan G. , Macintosh Bruce 
Published: September 2019

Abstract
All four circumbinary (CB) protoplanetary disks orbiting short-period (P < 20 days) double-lined spectroscopic binaries (SB2s)—a group that includes UZ Tau E, for which we present new Atacama Large Millimeter/Submillimeter Array data—exhibit sky-plane inclinations i
disk that match, to within a few degrees, the sky-plane inclinations i
⋆ of their stellar hosts. Although for these systems the true mutual inclinations θ between disk and binary cannot be directly measured because relative nodal angles are unknown, the near coincidence of i
disk and i
⋆ suggests that θ is small for these most compact of systems. We confirm this hypothesis using a hierarchical Bayesian analysis, showing that 68% of CB disks around short-period SB2s have θ < 3.°0. Near coplanarity of CB disks implies near coplanarity of CB planets discovered by Kepler, which in turn implies that the occurrence rate of close-in CB planets is similar to that around single stars. By contrast, at longer periods ranging from 30 to 105 days (where the nodal degeneracy can be broken via, e.g., binary astrometry), CB disks exhibit a wide range of mutual inclinations, from coplanar to polar. Many of these long-period binaries are eccentric, as their component stars are too far separated to be tidally circularized. We discuss how theories of binary formation and disk–binary gravitational interactions can accommodate all these observations.
HST Resolves Stars in a Tiny Body Falling on the Dwarf Galaxy DDO 68
Authors: Annibali F. , Bellazzini M. , Correnti M. , Sacchi E. , Tosi M. , Cignoni M. , Aloisi A. , Calzetti D. , Ciotti L. , Cusano F. , Lee J. , Nipoti C. 
Published: September 2019

Abstract
We present new Hubble Space Telescope imaging of a stream-like system associated with the dwarf galaxy DDO 68, located in the Lynx-Cancer void at a distance of D ∼ 12.65 Mpc from us. The stream, previously identified in deep Large Binocular Telescope images as a diffuse low surface brightness structure, is resolved into individual stars in the F606W (broad V) and F814W (∼I) images acquired with the Wide Field Camera 3. The resulting V, I color–magnitude diagram (CMD) of the resolved stars is dominated by old (age ≳ 1–2 Gyr) red giant branch (RGB) stars. From the observed RGB tip, we conclude that the stream is at the same distance as DDO 68, confirming the physical association with it. A synthetic CMD analysis indicates that the large majority of the star formation activity in the stream occurred at epochs earlier than ∼1 Gyr ago, and that the star formation at epochs more recent than ∼500 Myr ago is compatible with zero. The total stellar mass of the stream is ∼106
M
⊙, about 1/100 of that of DDO 68. This is a striking example of hierarchical merging in action at the dwarf galaxy scales.
Diamagnetic Plasma Clouds in the Near Lunar Wake Observed by ARTEMIS
Authors: Guo Dawei , Zhang Xiaoping , Xie Lianghai , Xu Xiaojun , Xu Aoao , Yan Qi , Xu Yi , Yang Fan 
Published: September 2019

Abstract
Because of the plasma pressure gradient across the lunar wake boundary, the interplanetary magnetic field is enhanced in the lunar wake. In previous works, the solar wind ions that enter into the near lunar wake are found to have an unimportant influence on the magnetic field within the lunar wake. In this study, two cases of a 22%–70% reduction of the magnetic field in the near lunar wake are first observed by the Acceleration, Reconnection, Turbulence and Electrodynamics of the Moon’s Interaction with the Sun mission (ARTEMIS). The magnetic field depressions are caused by the refilling of dense plasma clouds (with densities of 0.20–0.47 cm−3) into the near lunar wake. The ions of the plasma clouds that originate from the reflected solar wind ions in the lunar dayside are accelerated into the near lunar wake by the solar wind convection electric field. The source regions of the reflected ions can be traced back to the lunar magnetic anomalies over the sunlit surface. Pressure (magnetic pressure + thermal pressure) balances are roughly maintained for both cases at the boundary between the plasma cloud and the ambient plasma. Our results imply that the interaction between the solar wind and lunar magnetic anomalies drastically disturbs the near-Moon electromagnetic environment.