bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rheumatoid arthritis treated with 6-months of first-line biologic or biosimilar therapy: an updated systematic review and network meta-analysis
Authors: Simpson Emma L. , Ren Shijie , Hock Emma S. , Stevens John W. , Binard Aymeric , Pers Yves-Marie , Archer Rachel , Paisley Suzy , Stevenson Matthew D. , Herpin Chloé , Ghabri Salah 
Published: February 2019

AbstractObjectivesThe aim of this study was to estimate the effectiveness of first-line biologic disease modifying drugs(boDMARDs), and their approved biosimilars (bsDMARDs), compared with conventional (csDMARD) treatment, in terms of ACR (American College of Rheumatology) and EULAR (European League against Rheumatism) responses.MethodsSystematic literature search, on eight databases to January 2017, sought ACR and EULAR data from randomized controlled trials (RCTs) of boDMARDs / bsDMARDs (in combination with csDMARDs, or monotherapy). Two adult populations: methotrexate (MTX)-naïve patients with severe active RA; and csDMARD-experienced patients with moderate-to-severe active RA. Network meta-analyses (NMA) were conducted using a Bayesian Markov chain Monte Carlo simulation using a random effects model with a probit link function for ordered categorical.ResultsForty-six RCTs met the eligibility criteria. In the MTX-naïve severe active RA population, no biosimilar trials meeting the inclusion criteria were identified. MTX plus methylprednisolone (MP) was most likely to achieve the best ACR response. There was insufficient evidence that combination boDMARDs was superior to intensive (two or more) csDMARDs. In the csDMARD-experienced, moderate-to-severe RA population, the greatest effects for ACR responses were associated with tocilizumab (TCZ) monotherapy, and combination therapy (plus MTX) with bsDMARD etanercept (ETN) SB4, boDMARD ETN and TCZ. These treatments also had the greatest effects on EULAR responses. No clear differences were found between the boDMARDs and their bsDMARDs.ConclusionsIn MTX-naïve patients, there was insufficient evidence that combination boDMARDs was superior to two or more csDMARDs. In csDMARD-experienced patients, boDMARDs and bsDMARDs were comparable and all combination boDMARDs / bsDMARDs were superior to single csDMARD.
Time-series modelling and forecasting of hand, foot and mouth disease cases in China from 2008 to 2018
Authors: Tian C. W. , Wang H. , Luo X. M. 
Published: February 2019

AbstractSeasonal autoregressive-integrated moving average (SARIMA) has been widely used to model and forecast incidence of infectious diseases in time-series analysis. This study aimed to model and forecast monthly cases of hand, foot and mouth disease (HFMD) in China. Monthly incidence HFMD cases in China from May 2008 to August 2018 were analysed with the SARIMA model. A seasonal variation of HFMD incidence was found from May 2008 to August 2018 in China, with a predominant peak from April to July and a trough from January to March. In addition, the annual peak occurred periodically with a large annual peak followed by a relatively small annual peak. A SARIMA model of SARIMA (1, 1, 2) (0, 1, 1)12 was identified, and the mean error rate and determination coefficient were 16.86% and 94.27%, respectively. There was an annual periodicity and seasonal variation of HFMD incidence in China, which could be predicted well by a SARIMA (1, 1, 2) (0, 1, 1)12 model.
Parenting style moderates the effects of exposure to natural disaster-related stress on the neural development of reactivity to threat and reward in children
Authors: Kessel Ellen M. , Nelson Brady D. , Finsaas Megan , Kujawa Autumn , Meyer Alexandria , Bromet Evelyn , Carlson Gabrielle A. , Hajcak Greg , Kotov Roman , Klein Daniel N. 
Published: February 2019

AbstractLittle is known about the effect of natural disasters on children's neural development. Additionally, despite evidence that stress and parenting may both influence the development of neural systems underlying reward and threat processing, few studies have brought together these areas of research. The current investigation examined the effect of parenting styles and hurricane-related stress on the development of neural reactivity to reward and threat in children. Approximately 8 months before and 9 months after Hurricane Sandy, 74 children experiencing high and low levels of hurricane-related stress completed tasks that elicited the reward positivity and error-related negativity, event-related potentials indexing sensitivity to reward and threat, respectively. At the post-Hurricane assessment, children completed a self-report questionnaire to measure promotion- and prevention-focused parenting styles. Among children exposed to high levels of hurricane-related stress, lower levels of promotion-focused, but not prevention-focused, parenting were associated with a reduced post-Sandy reward positivity. In addition, in children with high stress exposure, greater prevention-focused, but not promotion-focused, parenting was associated with a larger error-related negativity after Hurricane Sandy. These findings highlight the need to consider contextual variables such as parenting when examining how exposure to stress alters the development of neural reactivity to reward and threat in children.
Are land values related to ambient air pollution levels? Hedonic evidence from Mexico City
Authors: Chakraborti Lopamudra , Heres David , Hernandez Danae 
Published: February 2019

AbstractThis article investigates whether residents of Mexico City value air quality. Our results suggest that air quality improvement in PM10 is equivalent to a marginal willingness to pay (MWTP) of US$440.31 per property for the period 2006–2013. The corresponding MWTP for PM2.5 is US$880.63, for O3 is US$623.78, and for SO2 is as much as US$2091.50. These estimates are considerably larger in magnitude compared to the few other studies in similar settings. As a percentage of annual household income, these represent 2.44 per cent for PM10, 4.88 per cent for PM2.5, 3.46 per cent for O3 and 11.59 per cent for SO2. Our estimates of land value–pollution elasticities for PM10 (−0.26 and − 0.58) are within range of hedonic estimates for total suspended particulate matter in US cities around the 1970s. The corresponding elasticities range from − 0.55 to − 0.84 for PM2.5, from − 0.06 to − 0.49 for O3 and from − 0.11 to − 0.34 for SO2.
Tracking Microscope Performance: A Workflow to Compare Point Spread Function Evaluations Over Time
Authors: Klemm Anna H. , Thomae Andreas W. , Wachal Katarina , Dietzel Steffen 
Published: February 2019

AbstractRoutine system checks are essential for supervising the performance of an advanced light microscope. Recording and evaluating the point spread function (PSF) of a given system provides information about the resolution and imaging. We compared the performance of fluorescent and gold beads for PSF recordings. We then combined the open-source evaluation software PSFj with a newly developed KNIME pipeline named PSFtracker to create a standardized workflow to track a system's performance over several measurements and thus over long time periods. PSFtracker produces example images of recorded PSFs, plots full-width-half-maximum (FWHM) measurements over time and creates an html file which embeds the images and plots, together with a table of results. Changes of the PSF over time are thus easily spotted, either in FWHM plots or in the time series of bead images which allows recognition of aberrations in the shape of the PSF. The html file, viewed in a local browser or uploaded on the web, therefore provides intuitive visualization of the state of the PSF over time. In addition, uploading of the html file on the web allows other microscopists to compare such data with their own.
BUNDER’S PARADOX
Authors: CAIE MICHAEL 
Published: February 2019

AbstractSystems ofillative logicare logical calculi formulated in the untypedλ-calculus supplemented with certain logical constants.1In this short paper, I consider a paradox that arises in illative logic. I note two prima facie attractive ways of resolving the paradox. The first is well known to be consistent, and I briefly outline a now standard construction used by Scott and Aczel that establishes this. The second, however, has been thought to be inconsistent. I show that this isn’t so, by providing a nonempty class of models that establishes its consistency. I then provide an illative logic which is sound and complete for this class of models. I close by briefly noting some attractive features of the second resolution of this paradox.
Dynamic Carbon Emission Linkages Across Boundaries
Authors: Chen Shaoqing , Liu Zhu , Chen Bin , Zhu Feiyao , Fath Brian D. , Liang Sai , Su Meirong , Yang Jin 
Published: February 2019

AbstractCities are increasingly linked to domestic and foreign markets during rapid globalization of trade. While transboundary carbon footprints of cities have been recently highlighted, we still have limited understanding of how carbon emission linkages between sectors are reshaping urban carbon footprints through time. In this study, we propose an integrated input‐output approach to trace the dynamics of various types of carbon emission linkages associated with a city. This approach quantifies full linkages in the urban carbon system from both production‐ and consumption‐based perspectives. We assess the dynamic roles that economic sectors and activities play in manipulating multiscale linkages induced by local, domestic, and international inputs. Using Beijing as a case study, we find that imports from domestic and foreign markets have an increasing impact on the city's carbon footprint with more distant linkages during the period from 1990 to 2012. The manufacturing‐related carbon emission linkages have been increasingly transferred outside the urban boundary since 2005, while the linkages from the energy sector to services sectors remain important in Beijing's local economy. Applying systems thinking to input‐output linkage analysis provides important details on when and how carbon emission linkages evolved in cities, whereby sector‐oriented and activity‐oriented carbon mitigation policies can be formulated.
Cloud Cover Feedback Moderates Fennoscandian Summer Temperature Changes Over the Past 1,000 Years
Authors: Young Giles H. F. , Gagen Mary H. , Loader Neil J. , McCarroll Danny , Grudd Håkan , Jalkanen Risto , Kirchhefer Andreas , Robertson Iain 
Published: February 2019

AbstractNorthern Fennoscandia has experienced little summer warming over recent decades, in stark contrast to the hemispheric trend, which is strongly linked to greenhouse gas emissions. A likely explanation is the feedback between cloud cover and temperature. We establish the long‐ and short‐term relationships between summer cloud cover and temperature over Northern Fennoscandia, by analyzing meteorological and proxy climate data. We identify opposing feedbacks operating at different timescales. At short timescales, dominated by internal variability, the cloud cover‐temperature feedback is negative; summers with increased cloud cover are cooler and sunny summers are warmer. However, over longer timescales, at which forced climate changes operate, this feedback is positive, rising temperatures causing increased regional cloud cover and vice versa. This has occurred both during warm (Medieval Climate Anomaly and at present) and cool (Little Ice Age) periods. This two‐way feedback relationship therefore moderates Northern Fennoscandian temperatures during both warm and cool hemispheric periods.
The Role of Mineral Composition on the Frictional and Stability Properties of Powdered Reservoir Rocks
Authors: Zhang Fengshou , An Mengke , Zhang Lianyang , Fang Yi , Elsworth Derek 
Published: February 2019

AbstractThe growing hazard of induced seismicity driven by the boom in unconventional resources exploitation is strongly linked to fault activation. We perform laboratory measurements on simulated fault gouges comprising powdered reservoir rocks from major oil and gas production sites in China, to probe the control of mineral composition on fault friction and stability responses during reservoir stimulation. Double direct shear experiments were conducted on gouges with phyllosilicate content ranging from 0 to 30 wt.% and grain sizes <150 μm, at constant normal stresses of 10–40 MPa and conditions of room temperature and water saturation. The velocity step and slide‐hold‐slide sequences were employed to evaluate frictional stability and static healing, respectively. Results indicate that the mineralogy of the gouges exhibit a strong control on the frictional strength, stability, and healing. Phyllosilicate‐rich samples show lower frictional strength μ and higher values of (a − b), promoting stable sliding. For the gouges studied, the frictional strength decreases monotonically with increasing phyllosilicate content, and a transition from velocity weakening to velocity strengthening behavior is evident at 15 wt.% phyllosilicates. Intermediate healing rates are common in gouges with higher content of phyllosilicates, with high healing rates predominantly in phyllosilicate‐poor gouges. As an indispensable component in reservoir rocks, the carbonates are shown to affect both the frictional stability and healing response. These findings can have important implications for understanding the effects of mineralogy on fault behavior and induced seismic potential in geoengineering activities, particularly in reservoirs in China.
Grain‐Displacive Gas Migration in Fine‐Grained Sediments
Authors: Sun Zhonghao , Santamarina J. Carlos 
Published: February 2019

AbstractGas migration mechanisms control the release of gas from seafloor sediments. We study underlying phenomena using transparent sediments subjected to controlled effective stress; this experimental approach allows high‐resolution real‐time monitoring of gas migration through cohesionless granular materials under 3‐D boundary conditions. Observed migration patterns depend on the effective stress at the time of injection and the stress history. Gas migration transitions from pore invasive to grain displacive when the capillary pressure for air entry ΔPAE is greater than the effective stress σ′. This study focuses on grain‐displacive gas migration. The morphology of grain‐displacive gas bodies changes with depth as the sediment stiffness G increases and the effect of surface tension γ vanishes: spheroidal gas bubbles form in the near‐surface, faceted cavities further down, and eventually open‐mode fractures develop at depth. The gas injection pressure is proportional to the effective stress in grain‐displacive migration. Preloading and overconsolidation cause the rotation of principal stresses and gas‐driven openings align with the new minimum principal stress direction. Cyclic loading promotes the upward migration of gas‐filled openings, and there is mechanical memory of previous gas pathways in sediments.
Structures of the Sea‐Breeze Front in Dual‐Doppler Lidar Observation and Coupled Mesoscale‐to‐LES Modeling
Authors: Chen Guixing , Iwai Hironori , Ishii Shoken , Saito Kazuo , Seko Hiromu , Sha Weiming , Iwasaki Toshiki 
Published: February 2019

AbstractSea‐breeze front (SBF) can cause dramatic changes in weather and air quality near the coast. However, the observation and forecast of its three‐dimensional (3‐D) fine‐scale structures have been challenging. Using mesoscale‐to‐large eddy simulations (LES) models and high‐resolution lidar measurement over Sendai Airport, here we perform a successful simulation of the observed 3‐D structures of an SBF for the first time. We show that frontal structures are characterized by a series of lobes (spaced ~500 m apart) aligned along the raised sea‐breeze head, where the shear between sea breeze and alongshore ambient flow aloft is evident. Local strong updrafts occur both in the frontal lobes of marine cold air and in the prefrontal warm air ascending the wedge of windward lobes. Downdrafts form behind the lifted marine cold air and trap air pollutants. These fine‐scale structures and vertical motions are repeatedly strengthened by the short‐term disturbances of gravity currents that move onshore and collide with the SBF. They are also affected by buildings and determine the detailed variations of surface winds. We conclude that advanced observation and modeling systems can potentially improve the prediction of coastal weather and environment.
Estimation and Uncertainty Analysis of Secondary Organic Carbon Using 1 Year of Hourly Organic and Elemental Carbon Data
Authors: Wu Cheng , Wu Dui , Yu Jian Zhen 
Published: February 2019

AbstractHourly particulate matter 2.5 organic carbon (OC) and elemental carbon (EC) ambient concentrations were measured from February 2012 to January 2013 at a suburban site in the city of Guangzhou, China. The major primary OC and EC sources at this site are vehicular exhaust and regional combustion sources. The annual average OC and EC concentrations (±1SD) were 7.30 ± 5.68 and 2.67 ± 2.28 μgC/m3, respectively. Taking advantage of this large data set of more than 7,000 measurements, we examined the diurnal variation dynamics of the primary OC‐to‐EC ratio ([OC/EC]pri), derived using the minimum R squared (MRS) method, which deploys an algorithm that calculates (OC/EC)pri by exploring the assumed independency between EC and secondary OC (SOC). The MRS‐derived hour‐by‐hour (OC/EC)pri was the lowest (1.8–2.0) for the morning hours while higher (2.4–3.0) for the afternoon and evening hours. Cumulative evidence from other pollutant measurements suggests that the increase in MRS‐derived (OC/EC)pri in the afternoon and evening was a result of SOC formation from photooxidation of precursors that covary with EC (e.g., vehicular exhaust) and thereby inflate (OC/EC)pri. We subsequently separate SOC into two categories based on their correlations with EC, that is, SOCa that covary with EC and SOCb that is unassociated with EC variations. SOCa and SOCb make comparable contributions to SOC, demonstrating that their separation is essential for a more accurate SOC estimation. Otherwise, SOCa would be mistakenly accounted as primary OC. This approach in estimating SOC may underestimate SOCa and subject to bias stemming from OC emissions from cooking and biomass burning.
Development and Evaluation of a Long‐Term Data Record of Planetary Boundary Layer Profiles From Aircraft Meteorological Reports
Authors: Zhang Yuanjie , Li Dan , Lin Zekun , Santanello Joseph A. , Gao Zhiqiu 
Published: February 2019

AbstractHigh‐quality measurements of planetary boundary layer (PBL) profiles are important for advancing our understanding of land‐atmosphere coupling and PBL processes and improving the predictive capability of numerical models. Now with more than 10 years of observations from Aircraft Meteorological Data Reports (AMDAR), a decade‐long (from 2007 to 2016) data record of hourly PBL profiles is developed over 54 U.S. airports. Comparisons between the derived hourly profiles and nearby radiosonde data, which are typically only available twice a day (at 00 and 12 UTC), show good agreement between the two data sets. The root‐mean‐square errors (RMSEs) between the AMDAR and radiosonde data are found to be dependent on the distance between the two data sets, especially at lower levels. The RMSEs of temperature generally decrease as the altitude increases, while the RMSEs of specific humidity and wind are positively correlated with the measurement magnitude. At perfect collocations (i.e., the separation distance is zero), the seasonal RMSEs at measurement levels with pressure larger than 850 hPa are 1.16–1.52 K, 0.64–1.25 g/kg, and 2.00–2.26 m/s for temperature, humidity, and wind components, respectively. Compared to the RMSEs, the mean biases of AMDAR profiles are much smaller and are less dependent on the separation distance. The RMSEs show little dependence on flight phases (ascent or descent) in the lower troposphere. Overall, our results indicate that the aircraft measurements are accurate enough to be an alternative to the radiosonde data and are better suited for investigating the diurnal variation of PBL due to their higher temporal resolution.
Phase Equilibria Modeling of Low‐Grade Metamorphic Martian Rocks
Authors: Semprich J. , Schwenzer S. P. , Treiman A. H. , Filiberto J. 
Published: February 2019

AbstractHydrous phases have been identified to be a significant component of Martian mineralogy. Particularly, prehnite, zeolites, and serpentine are evidence for low‐grade metamorphic reactions at elevated temperatures in mafic and ultramafic protoliths. Their presence suggests that at least part of the Martian crust is sufficiently hydrated for low‐grade metamorphic reactions to occur. A detailed analysis of changes in mineralogy with variations in fluid content and composition along possible Martian geotherms can contribute to determine the conditions required for subsurface hydrous alteration, fluid availability, and rock properties in the Martian crust. In this study, we use phase equilibria models to explore low‐grade metamorphic reactions covering a pressure‐temperature range of 0–0.5 GPa and 150–450 °C for several Martian protolith compositions and varying fluid content. Our models replicate the detected low‐grade metamorphic/hydrothermal mineral phases like prehnite, chlorite, analcime, unspecified zeolites, and serpentine. Our results also suggest that actinolite should be a part of lower‐grade metamorphic assemblages, but actinolite may not be detected in reflectance spectra for several reasons. By gradually increasing the water content in the modeled whole‐rock composition, we can estimate the amount of water required to precipitate low‐grade metamorphic phases. Mineralogical constraints do not necessarily require an elevated geothermal gradient for the formation of prehnite. However, restricted crater excavation depths even for large impact craters are not likely sampling prehnite along colder gradients, suggesting either a geotherm of ~20 °C/km in the Noachian or an additional heat source such as hydrothermal or magmatic activity.
Considerations for Globigerinoides ruber (White and Pink) Paleoceanography: Comprehensive Insights From a Long‐Running Sediment Trap
Authors: Richey Julie N. , Thirumalai Kaustubh , Khider Deborah , Reynolds Caitlin E. , Partin Judson W. , Quinn Terrence M. 
Published: February 2019

AbstractWe present a detailed analysis of the seasonal distribution, size, morphological variability, and geochemistry of co‐occurring pink and white chromotypes of Globigerinoides ruber from a high‐resolution (1–2 weeks) and long‐running sediment trap time series in the northern Gulf of Mexico. We find no difference in the seasonal flux of the two chromotypes. Although flux of G. ruber is consistently lowest in winter, the flux‐weighted signal exported to marine sediments represents mean annual conditions in the surface mixed layer. We observe the same morphological diversity among pink specimens of G. ruber as white. Comparison of the oxygen and carbon isotopic composition (δ18O and δ13C) of two morphotypes (sensu stricto and sensu lato) of pink G. ruber reveals the isotopes to be indistinguishable. The test size distribution within the population varies seasonally, with the abundance of large individuals increasing (decreasing) with increasing (decreasing) sea surface temperature. We find no systematic offsets in the Mg/Ca and δ18O of co‐occurring pink and white G. ruber. The sediment trap data set shows that the Mg/Ca‐temperature sensitivity for both chromotypes is much lower than the canonical 9%/°C, which can likely be attributed to the secondary influence of both salinity and pH on foraminiferal Mg/Ca. Using paired Mg/Ca and δ18O, we evaluate the performance of a suite of published equations for calculating sea surface temperature, sea surface salinity, and isotopic composition of seawater (δ18Osw), including a new salinity‐δ18Osw relationship for the northern Gulf of Mexico from water column observations.