bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le pronomyaccusatif en français régional et dans les dialectes galloromans
Authors: Avanzi Mathieu 
Published: August 2018

RésuméLe but de cet article est de porter un regard nouveau sur le pronomyaccusatif dit « neutre » dans le français et dans les dialectes galloromans de la région de Lyon (di-m-z-i = dis-moi-z-y ; d’i sé ben = j’y sais bien). L’examen de données bibliographiques et atlantographiques rarement sollicitées jusque-là permet en effet de montrer que (i) les premières attestations deyaccusatif remontent plus ou moins à la même époque en patois qu’en français ; que (ii) en patois comme en français, il est fort vraisemblable que le pronomyait acquis le statut d’accusatif à la suite de la réanalyse de la valence de verbes qui présentaient des ambiguïtés de construction (p.ex.le/y croire ; le/y penser), et que c’est la généralisation de ces ambiguïtés qui a favorisé son installation ; (iii) que la formey(< HIC) s’est substituée aux formes héréditaires de neutre à des époques différentes selon les régions : l’élimination progressive des aboutissants de HOC parys’est faite au fur et à mesure que l’usage du patois reculait, et que le français gagnait de l’ampleur.
Patterns of 1st and 3rd person marking in Oïl-Galloromance
Authors: Massot Benjamin 
Published: August 2018

SummaryThis article is a contribution to the long-standing discussion of subject marking in Romance. Its originality lies in its systematically considering data from Oïl-Galloromance dialects, i.e. non-pro-drop varieties, which had been ignored because they were thought to pattern like French. On the contrary, a detailed survey of the means of 1sgand 3sg.m. Marking in these dialects reveals that the obligatoriness of the subject clitics in all grammatical persons does not guarantee the absence of ambiguous marks, since cases of syncretism between these two persons were found, besides cases of marking even more redundant than in French. I then conclude that it is yet another refutation of the now generally abandoned wisdom according to which the subject pronouns exactly compensate the loss of verb endings. Moreover, the results make the pro-drop parameter and parametric theory hard to maintain, as has been observed from other microvariational studies. I also argue against a functionalist interpretation of the correlation between the different means of subject marking based on the assumption of avoidance and repair strategies underlying language change/dialectal fragmentation. My own analysis then relies on the assumption of a strong and stable typological property of accusative languages like Romance, called here the principle of recovery of the subject. The surface microvariation within (Oïl)-(Gallo)romance is simply seen as the result of non-deterministic properties of language change/dialectal fragmentation.
Increasing multilingualism in schoolscapes
Authors: Menken Kate , Pérez Rosario Vanessa , Guzmán Valerio Luis Alejandro 
Published: August 2018

Abstract
In this qualitative research study, we examine changes made in 23 New York City schools that participated in a project for which
participating schools were asked to regard bilingualism as a resource in instruction and develop a multilingual linguistic
landscape. Findings document efforts made by schools to change their linguistic landscape in ways that recognize students’ many
languages and cultures, significant corresponding ideological shifts by school leaders from monolingual to multilingual views of
language and language learning, educators’ incorporation of students’ home languages in instruction, and new formal language
education policies resulting from these efforts. We document the impact of all of these changes on students and their families and
suggest that research on linguistic landscape conducted in schools should consider not only the physical landscape but also its
connections to pedagogy, programming, and language policies.
Itineracy immobilised
Authors: Leimgruber Jakob R. E. 
Published: August 2018

Abstract
A famous element in Singapore’s food culture is the hawker centre, consisting of a large collection of individually-run stalls
selling various kinds of foods and drinks. These centres, which dot the island and its public housing estates, were built on
government initiative beginning in the 1970s, with the prime objective of sedentarising the large number of erstwhile itinerant
street hawkers, based on a discourse of promoting ‘cleanliness’ inherent to the entire nation-building narrative of the country.
The sedentarised hawkers, now divorced from their earlier way of life and often from their earlier neighbourhoods, had to start
naming their businesses overtly. Some did so by including references to the geographical location of their earlier area of street
hawking. The linguistic landscape of stall signboards in a hawker centre exhibits various attempts to come to terms with this
immobilised itineracy.
Lexis and grammar as complementary discourse systems for expressing stance and evaluation
Authors: Biber Douglas , Egbert Jesse , Zhang Meixiu 
Published: August 2018

Abstract
Although ‘stance’ and ‘evaluation’ are closely related theoretical constructs, stance is normally investigated through corpus-based methods focusing on the use of lexico-grammatical features, while evaluative language, being regarded as more context-dependent, has been investigated through the use of particular words and phrases in individual texts. This study explores the possibility that these two linguistic systems are partially complementary, with some registers relying on lexico-grammatical stance features and others on evaluative lexis. We compare the linguistic discourse styles of three opinionated/persuasive web registers: ‘Opinion Blogs’ (OB), ‘Reviews’ (RV), and ‘Descriptions-with-intent-to-Sell’ (DS). We show that OB and RV use grammatical stance devices more but DS considerably less than most other web registers. However, our detailed study of the lexical keywords found in these three registers reveals the opposite pattern of use.
A contrastive study on mitigation of criticism in English and Chinese book reviews
Authors: Qian Yubin 
Published: August 2018

Abstract
The present article is a corpus-based contrastive study on mitigation of criticism in linguistic book reviews in English and in Chinese. It is based on the face theory of Brown and Levinson (1987) and follows the framework of Johnson and Roen (1992). The present article shows the following results: (1) at the local level, there are thirteen mitigation devices in the corpus, of which only six have been introduced by previous studies; devices of ‘generalization’ and ‘metaphorical statement’ are specific to the English sub-corpus, whereas ‘omission’ is only found in Chinese; (2) at the global level, English writers maintain an overall supportive tone with praise largely distributed in both openings and closings, whereas their Chinese counterparts sound much impartial. Differences in findings are then explained from perspectives of cultural values and functions of book reviews.
Percepción del lenguaje político en Twitter
Authors: Martín José Segovia 
Published: August 2018

ResumenEn el presente trabajo proponemos un acercamiento cuantitativo al discurso político en la red demicrobloggingTwitter. El objetivo principal de esta investigación consistió en determinar algunos de los factores que pueden estar influyendo en la percepción del lenguaje político en esta red. El análisis estadístico de los datos recogidos, a partir de 100 tuits y 100 encuestados, permitió evidenciar que las variablesRE/C(P = 0,0081) ytema discursivo(P < 0.0001) están relacionadas significativamente con eldestaquede los tuits. Asimismo, eldestaque(P = 0,0186) está relacionado con elrecuerdo(MLP) de los tuits, si bien el modelo explica solo un leve porcentaje de la variabilidad.
The use of L3 English articles by Basque-Spanish bilinguals
Authors: Gutiérrez-Mangado María Juncal , Martínez-Adrián María 
Published: August 2018

Abstract
In this paper we compare the data from a group of L1 Basque-Spanish bilingual learners of L3 English with a matching group of L1 Spanish learners of L2 English. The results show that the bilinguals omit articles and overuse ‘the’ more than the L1 Spanish group. The pattern of omissions by the bilinguals shows that one subgroup omitted heavily while the other produced only sporadic omissions. With respect to overuse, the bilinguals consistently overused ‘the’ in indefinite contexts, while ‘a’ overuse was practically absent. The results from the bilingual group pattern with findings from [−article] L1 learners, a pattern which would fit with an analysis of Basque as a language without articles (Manterola 2012, 2015). The finding that the bilinguals do not transfer article semantics from Spanish, unlike the learners in the L1 Spanish group, suggests that recency may be determining the language of transfer in the bilingual learners tested.
Lactation Outcomes in More Than 3500 Women Following Primary Augmentation: 5-Year Data From the Breast Implant Follow-Up Study
Authors: Jewell Mark L , Edwards Michael C , Murphy Diane K , Schumacher Andrew 
Published: August 2018

AbstractBackgroundWomen with breast implants may have concerns about their ability to successfully breast-feed. The Breast Implant Follow-up Study (BIFS-001) is a large, 10-year observational study evaluating the performance and safety of Natrelle round silicone gel-filled breast implants.ObjectivesThis analysis compared lactation outcomes in women enrolled in BIFS-001 who gave birth after they underwent primary augmentation with Natrelle round silicone implants or saline implants.MethodsAt baseline and annually after surgery (>5-year visit window), patients completed questionnaires regarding pregnancy and lactation. Comparisons were made using summary statistics and odds ratios with 90% confidence intervals (OR [90% CI]).ResultsA total of 4679 subjects gave birth at least once after primary augmentation for a total of 5736 live births during the study (silicone, 3695 births; saline, 2041 births). Of these, 3715 (79.4%) women breast-fed at least 1 child, resulting in 80.0% (silicone) and 75.9% (saline) of babies being breast-fed. The most common complication was insufficient milk production, which was reported for 19.6% (silicone) and 19.8% (saline) of single births (OR, 0.94 [0.83, 1.06]). Complications occurred at similar rates in each group when evaluated by incision type, implant size, pocket location, and age.ConclusionsIn this large group of women who gave birth after primary breast augmentation with Natrelle round silicone implants or saline implants, most were able to breast-feed their infants without complications. Lactation complications were comparable between the silicone and saline cohorts, and the incidence was comparable to reports in the general population of women who breast-feed.Level of Evidence: 2
Designing a wrist-worn sensor to improve medication adherence: accommodating diverse user behaviors and technology preferences
Authors: Marquard Jenna L , Saver Barry , Kandaswamy Swaminathan , Martinez Vanessa I , Simoni Jane M , Stekler Joanne D , Ganesan Deepak , Scanlan James 
Published: August 2018

Abstract

Objectives
High medication adherence is important for HIV suppression (antiretroviral therapy) and pre-exposure prophylaxis efficacy. We are developing sensor-based technologies to detect pill-taking gestures, trigger reminders, and generate adherence reports.

Materials and Methods
We collected interview, observation, and questionnaire data from individuals with and at-risk for HIV (N = 17). We assessed their medication-taking practices and physical actions, and feedback on our initial design.

Results
While participants displayed diverse medication taking practices and physical actions, most (67%) wanted to use the system to receive real-time and summative feedback, and most (69%) wanted to share data with their physicians. Participants preferred reminders via the wrist-worn device or mobile app, and summative feedback via mobile app or email.

Discussion
Adoption of these systems is promising if designs accommodate diverse behaviors and preferences.

Conclusion
Our findings may help improve the accuracy and adoption of the system by accounting for user behaviors, physical actions, and preferences.
Assessing the Civil Society’s Role in Refugee Integration in Turkey: NGO-R as a New Typology
Authors: Sunata Ulaş , Tosun Salіh 
Published: August 2018

AbstractAfter the Syrian refugee influx in Turkey, the aspect of civil society in integration needs further clarification and categorization. Therefore, in this study, we aim to develop a general typology of NGOs (non-governmental organizations) that are active in immigration and immigration-related areas (NGO-R; non-governmental organizations—refugees). Our findings show that NGO-Rs play crucial roles in helping the refugees to access the rights provided by state, in integrating them into society at the local level by creating new social spaces and in sending humanitarian aid to the people of concern in Syria. Additionally, we claim that the refugee crisis facilitated the opportunities both for active citizenship as demanded and for new mobilization to manage the humanitarian and integration assistance towards the Syrians. Lastly, our fieldwork shows that religious and belief motives are the main factors playing a large part in the creation and maintenance of the NGO-R activities and refugee community organizations (RCOs) can have a distinctive integrative function by preferring to stay outside the mainstream channels.
Hypoxic preconditioning attenuates necroptotic neuronal death induced by global cerebral ischemia via Drp1‐dependent signaling pathway mediated by CaMKIIα inactivation in adult rats
Authors: Zhan Lixuan , Lu Zhiwei , Zhu Xinyong , Xu Wensheng , Li Luxi , Li Xinyu , Chen Siyuan , Sun Weiwen , Xu En 
Published: August 2018

ABSTRACTHypoxic preconditioning (HPC) alleviates the selective and delayed neuronal death in the hippocampal CA1 region induced by transient global cerebral ischemia (tGCI). This type of cell death may include different programmed cell death mechanisms, namely, apoptosis and necroptosis. Although apoptotic signaling is well defined, the mechanisms that underlie neuronal necroptosis are yet to be fully elucidated. In this study, we investigated whether HPC protects neurons from cerebral ischemia‐induced necroptosis. We observed that tGCI up‐regulated the expression of receptor‐interacting protein (RIP) 3 and increased the interaction of RIP1‐RIP3 in CA1 at the early stage of reperfusion. The pretreatment with HPC or necrostatin‐1 decreased the expression of RIP3 and the formation of RIP1–RIP3 after tGCI. We also found that HPC decreased the expression and the activity of caspase‐8 in CA1 after tGCI, and notably, the pretreatment with Z‐VAD‐FMK, a pan‐caspase inhibitor, did not trigger necroptosis but attenuated the tGCI‐induced neuronal damage. Furthermore, we demonstrated that HPC decreased the activation of calcium‐calmodulin kinase (CaMK) IIa and the interaction of RIP1 and CaMKIIα induced by tGCI. Intriguingly, the pretreatment with a CaMKs inhibitor KN‐93 before tGCI resulted in significantly reduced RIP1–3 interaction and tGCI‐induced neuronal damage. Finally, we ascertained that HPC prevented the dephosphorylation of dynamin‐related protein 1 (Drp1)–Ser637 (serine 637) and inhibited the translocation of Drp1 to mitochondria induced by tGCI. Importantly, the treatment with a Drp1 inhibitor Mdivi‐1 or necrostatin‐1 before tGCI also abolished Drp1 dephosphorylation at Ser637 and mitochondrial translocation. Taken together, our results highlight that HPC attenuates necroptotic neuronal death induced by tGCI via Drp1‐dependent mitochondrial signaling pathways mediated by CaMKIIα inactivation.—Zhan, L., Lu, Z., Zhu, X., Xu, W., Li, L., Li, X., Chen, S., Sun, W., Xu, E. Hypoxic preconditioning attenuates necroptotic neuronal death induced by global cerebral ischemia via Drp1‐dependent signaling pathway mediated by CaMKIIα inactivation in adult rats. FASEB J. 33, 1313–1329 (2019). www.fasebj.org
GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues
Authors: Lipina Christopher , Walsh Sarah K. , Mitchell Sharon E. , Speakman John R. , Wainwright Cherry L. , Hundal Harinder S. 
Published: August 2018

ABSTRACTEmerging evidence indicates that G‐protein coupled receptor 55 (GPR55), a nonclassic receptor of the endocannabinoid system that is activated by L‐α‐lysophosphatidylinositol and various cannabinoid ligands, may regulate endocrine function and energy metabolism. We examined how GPR55 deficiency and modulation affects insulin signaling in skeletal muscle, adipose tissue, and liver alongside expression analysis of proteins implicated in insulin action and energy metabolism. We show that GPR55‐null mice display decreased insulin sensitivity in these tissues, as evidenced by reduced phosphorylation of PKB/Akt and its downstream targets, concomitant with increased adiposity and reduced physical activity relative to wild‐type counterparts. Impaired tissue insulin sensitivity coincided with reduced insulin receptor substrate‐1 abundance in skeletal muscle, whereas in liver and epididymal fat it was associated with increased expression of the 3‐phosphoinoistide lipid phosphatase, phosphatase and tensin homolog. In contrast, GPR55 activation enhanced insulin signaling in cultured skeletal muscle cells, adipocytes, and hepatocytes; this response was negated by receptor antagonists and GPR55 gene silencing in L6 myotubes. Sustained GPR55 antagonism in 3T3‐L1 adipocytes enhanced expression of proteins implicated in lipogenesis and promoted triglyceride accumulation. Our findings identify GPR55 as a positive regulator of insulin action and adipogenesis and as a potential therapeutic target for countering obesity‐induced metabolic dysfunction and insulin resistance.—Lipina, C., Walsh, S. K., Mitchell, S. E., Speakman, J. R., Wainwright, C. L., Hundal, H. S. GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues. FASEB J. 33, 1299–1312 (2019). www.fasebj.org
Sunitinib induces early histomolecular changes in a subset of renal cancer cells that contribute to resistance
Authors: Lichner Zsuzsanna , Saleeb Rola , Butz Henriett , Ding Qiang , Nofech-Mozes Roy , Riad Sara , Farag Mina , Varkouhi Amir K. , dos Santos Claudia C. , Kapus András , Yousef George M. 
Published: August 2018

ABSTRACTSunitinib is the standard‐of‐care, first‐line treatment for advanced renal cell carcinoma (RCC). Characteristics of treatment‐resistant RCC have been described; however, complex tumor adaptation mechanisms obstruct the identification of significant operators in resistance. We hypothesized that resistance is a late manifestation of early, treatment‐induced histomolecular alterations; therefore, studying early drug response may identify drivers of resistance. We describe an epithelioid RCC growth pattern in RCC xenografts, which emerges in sunitinib‐sensitive tumors and is augmented during resistance. This growth modality is molecularly and morphologically related to the RCC spheroids that advance during in vitro treatment. Based on time‐lapse microscopy, mRNA and microRNA screening, and tumor behavior‐related characteristics, we propose that the spheroid and adherent RCC growth patterns differentially respond to sunitinib. Gene expression analysis indicated that sunitinib promoted spheroid formation, which provided a selective survival advantage under treatment. Functional studies confirm that E‐cadherin is a key contributor to the survival of RCC cells under sunitinib treatment. In summary, we suggest that sunitinib‐resistant RCC cells exist in treatment‐sensitive tumors and are histologically identifiable.—Lichner, Z., Saleeb, R., Butz, H., Ding, Q., Nofech‐Mozes, R., Riad, S., Farag, M., Varkouhi, A. K., dosSantos, C. C., Kapus, A., Yousef, G. M. Sunitinib induces early histomolecular changes in a subset of renal cancer cells that contribute to resistance. FASEB J. 33, 1347–1359 (2019). www.fasebj.org
An update on autoantibodies in scleroderma
Authors: Mecoli Christopher A. , Casciola-Rosen Livia 
Published: August 2018

Purpose of reviewNew research continues to provide important insights into the utility of antibody specificities. This review provides an update of recent findings, and the important insights they provide into disease mechanism.Recent findingsA growing number of autoantibodies have been discovered in scleroderma patients with unique clinical associations. A subgroup of these antibodies may have functional consequences and contribute to disease pathogenesis, driving the vascular and fibrotic phenotype. Recent research into the relationship between malignancy and scleroderma onset provides important new insights into disease mechanism, and highlights the utility of autoantibodies as unique research probes.SummaryContinued advances in the study of scleroderma antibody specificities has led to important insights into disease pathogenesis and clinical subgrouping. These advances include newly described specificities, functional antibodies and an emerging understanding of the cancer–scleroderma relationship.
Climatic factors and species range position predict sexually antagonistic selection across taxa
Authors: De Lisle Stephen P. , Goedert Debora , Reedy Aaron M. , Svensson Erik I. 
Published: August 2018

Sex differences in selection are ubiquitous in sexually reproducing organisms. When the genetic basis of traits is shared between the sexes, such sexually antagonistic selection (SAS) creates a potential constraint on adaptive evolution. Theory and laboratory experiments suggest that environmental variation and the degree of local adaptation may all affect the frequency and intensity of SAS. Here, we capitalize on a large database of over 700 spatially or temporally replicated estimates of sex-specific phenotypic selection from wild populations, combined with data on microclimates and geographical range information. We performed a meta-analysis to test three predictions from SAS theory, that selection becomes more concordant between males and females: (1) in more stressful environments, (2) in more variable environments and (3) closer to the edge of the species' range. We find partial empirical support for all three predictions. Within-study analyses indicate SAS decreases in extreme environments, as indicated by a relationship with maximum temperature, minimum precipitation and evaporative potential (PET). Across studies, we found that the average level of SAS at high latitudes was lower, where environmental conditions are typically less stable. Finally, we found evidence for reduced SAS in populations that are far from the centre of their geographical range. However, and notably, we also found some evidence of reduced average strength of selection in these populations, which is in contrast to predictions from classical theoretical models on range limit evolution. Our results suggest that environmental lability and species range position predictably influence sex-specific selection and sexual antagonism in the wild.
This article is part of the theme issue ‘Linking local adaptation with the evolution of sex differences’.