bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complete protein assignment from sets of spectra recorded overnight
Authors: Fredriksson Jonas , Bermel Wolfgang , Billeter Martin 
Published: February 2019

Abstract
A flexible and scalable approach for protein NMR is introduced that builds on rapid data collection via projection spectroscopy and analysis of the spectral input data via joint decomposition. Input data may originate from various types of spectra, depending on the ultimate goal: these may result from experiments based on triple-resonance pulse sequences, or on TOCSY or NOESY sequences, or mixtures thereof. Flexible refers to the free choice of spectra for the joint decompositions depending on the purpose: assignments, structure, dynamics, interactions. Scalable means that the approach is open to the addition of similar or different experiments, e.g. larger proteins may require a wider selection of triple-resonance based experiments. Central to the proposed approach is the mutual support among the different spectra during the spectral analysis: for example, sparser triple-resonance spectra may help decomposing (separating) spin systems in a TOCSY or identifying unique NOEs. In the example presented, backbone plus side chain assignments of ubiquitin were obtained from the combination of either two or three of the following projection experiments: a 4D HCCCONH, a 4D HNCACO and a 3D HNCACB. In all cases, TOCSY data (4D HCCCONH) proved crucial not only for the side chain assignments, but also for the sequential assignment. Even when total recording time was reduced to about 10 h, nearly complete assignments were obtained, with very few missing assignments and even fewer differences to a reference.
Generalizing empirical adequacy II: partial structures
Authors: Lutz Sebastian 
Published: February 2019

AbstractI show that extant attempts to capture and generalize empirical adequacy in terms of partial structures fail. Indeed, the motivations for the generalizations in the partial structures approach are better met by the generalizations via approximation sets developed in “Generalizing Empirical Adequacy I” (Lutz in Synthese 191:3195–3225, 2014b.10.1007/s11229-014-0440-3). Approximation sets also generalize partial structures.
Staging biomarkers in preclinical autosomal dominant Alzheimer's disease by estimated years to symptom onset
Authors: Wang Guoqiao , Coble Dean , McDade Eric M. , Hassenstab Jason , Fagan Anne M. , Benzinger Tammie L.S. , Bateman Randall J. , Morris John C. , Xiong Chengjie ,   and the Dominantly Inherited Alzheimer Network (DIAN)
Published: February 2019

AbstractIntroductionStaging preclinical Alzheimer disease (AD) by the expected years to symptom onset (EYO) in autosomal dominant AD (ADAD) through biomarker correlations is important.MethodsWe estimated the correlation matrix between EYO/cognition and imaging/CSF biomarkers, and searched for the EYO cutoff where a change in the correlations occurred before and after the cutoff among the asymptomatic mutation carriers of ADAD. We then estimated the longitudinal rate of change for biomarkers/cognition within each preclinical stage defined by the EYO.ResultsBased on the change in the correlations, the preclinical ADAD was divided by EYOs −7 and −13 years. Mutation carriers demonstrated a temporal ordering of biomarker/cognition changes across the three preclinical stages.DiscussionDuration of each preclinical stage can be estimated in ADAD, facilitating better planning of prevention trials with the EYO cutoffs under the recently released FDA guidance. The generalization of these results to sporadic AD warrants further investigation.
A framework to define the relationship between cyber security and cloud performance
Authors: Bhardwaj Akashdeep , Goundar Sam 
Published: February 2019

Cloud computing has become one of the most critical components of businesses and corporate organisations worldwide. It is a technology that has applications and services running on distributed networks and pooled virtualised resources that small, medium and large organisations can utilise to host their applications, processes and portals online via datacentres to provide access over the Internet to end users, customers and employees. In today's dynamic business world, traditional IT systems cannot keep up with ever-changing market demands and complex environments. Cloud computing has become one of the most critical components of enterprises worldwide. In today's dynamic business world, traditional IT systems cannot keep up with ever-changing market demands and complex environments. Many organisations are seeking an all-purpose cloud deployment to achieve increased service quality, which translates into better security and higher performance. In such cases, it becomes critical to concentrate on metrics for security and performance. Akashdeep Bhardwaj and Sam Goundar propose a framework for examining those two crucial elements.
Vitamins and Minerals for Migraine Prophylaxis: A Systematic Review and Meta-analysis
Authors: Okoli George N. , Rabbani Rasheda , Kashani Hessam H. , Wierzbowski Aleksandra K. , Neilson Christine , Mansouri Behzad , Zarychanski Ryan , Abou-Setta Ahmed M. 
Published: February 2019

ABSTRACT:Objective: To summarize the findings of randomized controlled trials (RCTs) on the efficacy and safety of vitamins and minerals for migraine prophylaxis. Methods: We systematically searched bibliographic databases and relevant websites for parallel and crossover RCTs reporting efficacy and/or safety of vitamins and/or minerals for migraine prophylaxis. Our primary outcomes were migraine frequency (number of attacks) and duration (hours). Secondary outcomes were severity (intensity), days with migraine, and adverse events. Meta-analysis was conducted when analyzable data were available from at least two trials. Results: Eighteen placebo-controlled trials met our eligibility criteria. Only coenzyme Q10 and magnesium contributed to meta-analyses. In adults, compared with placebo, coenzyme Q10 did not significantly decrease migraine frequency (mean difference (MD) −0.44 (−2.14 to 1.26); I2 53%; 2 trials; 97 participants; moderate strength of the evidence), duration (MD −1.97 (−4.82 to 0.87); I2 0%; 2 trials; 97 participants; moderate strength of the evidence), or severity (ratio of means (RoM) −0.05 (−0.20 to 0.11); I2 0%; 2 trials; 97 participants). In adults, compared with placebo, magnesium did not significantly decrease migraine severity (RoM −0.17 (−0.36 to 0.02); I2 48%; 3 trials; 226 participants; low strength of the evidence). Meta-analysis of other vitamins and minerals, and other outcomes were not feasible due to a lack of sufficiently reported data. Conclusions: Based on insufficient evidence, it is unknown if coenzyme Q10 and magnesium are effective for migraine prophylaxis in adults. High-quality, adequately powered RCTs are needed to fully evaluate the efficacy and safety of vitamins and minerals for migraine prophylaxis.
Comment on ‘Electron acoustic super solitary waves in a magnetized plasma’, J. Plasma Phys. 84, 905840406 (2018)
Authors: Verheest Frank , Hellberg Manfred A. 
Published: February 2019

The plasma model used in a recent paper by Kamalam et al. (J. Plasma Phys., vol. 84, 2018, 905840406) assumes a Boltzmann description for two hot ion species, in the presence of two adiabatic (fluid) electron species, for the study of obliquely propagating acoustic-type nonlinear solitary waves with respect to a static magnetic field. We argue that the assumption of Boltzmann distributions for the hot ions is incorrect, thus invalidating their conclusions, in particular about the possible occurrence of supersolitons in magnetized plasmas.
Larval development of the brush-clawed shore crab Hemigrapsus takanoi Asakura & Watanabe, 2005 (Decapoda, Brachyura, Varunidae)
Authors: Landeira Jose M. , Cuesta Jose A. , Tanaka Yuji 
Published: February 2019

AbstractThe brush-clawed shore crab Hemigrapsus takanoi is a native species from the Western Pacific and an invader of the European Atlantic coast from northern Spain to southern Denmark. Despite the increasing concern about its rapid expansion, little is known about the early stages in its life history. In the present study, the larval morphology of H. takanoi is described and illustrated from specimens obtained in the laboratory from its type locality, Tokyo Bay, Japan. Its larval development follows the pattern of Varunidae, that involves five zoeae and one megalopa. The morphological characters of the larvae of H. takanoi are compared with those of the other known Hemigrapsus species of the North Pacific. In addition, to facilitate an early detection of the invasive species of Varunidae inhabiting European Atlantic waters, a summary of the key characters to identify their larval stages is included.
Utilisation of a three-dimensional printed model for the management of coronary-pulmonary artery fistula from left main coronary artery
Authors: Misra Amrit , Walters Henry L. , Kobayashi Daisuke 
Published: February 2019

AbstractCoronary-pulmonary artery fistula is a rare anomaly in which an aortopulmonary collateral artery arises from a coronary artery, often seen in patients with pulmonary atresia with ventricular septal defect. In the presented case, a coronary-pulmonary artery fistula arose from the left main coronary artery and supplied blood flow to a left upper lobe segment. The life-sized three-dimensional printed model was helpful in pre-surgical planning for unifocalisation of the aortopulmonary collateral arteries.
Comparative dosimetric analysis of whole abdominal radiotherapy with VMAT versus 3D conformal in patients with Wilms tumour
Authors: Olmos Alejandro , Rodriguez Alejandro , Beltran Estefania , Garay Onix , Felix Armando , Ponce Mario Alberto , Salcedo Maurico , Apresa Teresa , Lio Lorena , Guzman Martha , Chilaca Fatima 
Published: February 2019

AbstractIntroductionIn this study, we undertake a dosimetric comparison of whole abdominal treatment plans of patients diagnosed with stage 3 Wilms tumour, to assess the benefits of treating these patients with volumetric arch therapy (VMAT) versus 3D conformal radiotherapy.Material and methodsA retrospective study was undertaken on 23 patients receiving either VMAT or 3D conformal radiotherapy during 2013–2017. A dosimetric comparison was undertaken for both techniques, measuring planning target volume (PTV), conformity index (CI), homogeneity index (HI) and organs at risk (OAR).ResultsThe dosimetric parameters for the PTV dose in the VMAT and 3D conformal technique showed no statistical difference (1,289·17 cGy versus 1,357·13 cGy, respectively, p=0·404). However, the VMAT technique had a better CI (1·04 VMAT versus 1·26 3D, p=0·004), and there was little difference in the HI (1·13 VMAT versus 1·15 3D, p=0·1606). In the statistical analysis, the decrease in dose to OAR for the VMAT technique is statistically significant for doses to lung and kidney (p=0·011 and p=0·002, respectively). Between the two techniques, there was no statistical significance in dose difference to the other OAR.ConclusionThis work proposes using the VMAT technique in whole abdominal irradiation to improve conformity, without affecting the quality of the PTV coverage, when compared with the 3D conformal technique. In addition, VMAT reduces the doses to OAR such as the remaining kidney and lungs that are important to preserve to reduce the probability of radiation toxicity in these patients.
Slab Control on the Northeastern Edge of the Mid‐Pacific LLSVP Near Hawaii
Authors: Sun D. , Helmberger D. , Lai V. H. , Gurnis M. , Jackson J. M. , Yang H.‐Y. 
Published: February 2019

AbstractAt the core‐mantle boundary, most observed ultralow velocity zones (ULVZs) cluster along the edges of the large low shear velocity provinces (LLSVPs) and provide key information on the composition, dynamics, and evolution of the lower mantle. However, their detailed structure near slab‐like structures beneath the mid‐Pacific remains particularly challenging because of the lack of station coverage. While most studies of ULVZs concentrate on SKS‐complexity, here we report on the multipathing of ScS, which expands the sampling for ULVZs. We find the strongest multipathing along a ULVZ patch located just south of Hawaii and the far northeastern edge of the LLSVP, in a zone ~200 km in width and extending 600 km southward. The anomalous ScS travel times and distorted Sdiff waveforms further reveal patches interrupted by observed enhanced D″ indicative of slab‐debris influence on the complexity of the northeastern boundary of the mid‐Pacific LLSVP.
Rupture Model of the M5.8 Pawnee, Oklahoma, Earthquake From Regional and Teleseismic Waveforms
Authors: Moschetti M. P. , Hartzell S. H. , Herrmann R. B. 
Published: February 2019

AbstractThe 2016 M5.8 Pawnee, Oklahoma, earthquake is the largest earthquake to have been induced by wastewater disposal. We infer the coseismic slip history from analysis of apparent source time functions and inversion of regional and teleseismic P waveforms, using aftershocks as empirical Green's functions. The earthquake nucleated on the shallow part of the fault, initially rupturing toward the surface, followed shortly thereafter by slip deeper on the fault. Deeper slip occurred below the aftershocks and at greater depths than most induced seismicity in the region, suggesting that small‐ to moderate‐sized earthquakes may not occur on deeper parts of faults in Oklahoma because they are further from failure than shallower fault sections. Comparisons with models of pore pressure perturbations further suggest that the earthquake may have initiated within a region of higher pore pressure perturbation but was not confined to this zone. These observations inform source physics and understanding of maximum magnitudes.
Illuminating Faulting Complexity of the 2017 Yellowstone Maple Creek Earthquake Swarm
Authors: Shelly David R. , Hardebeck Jeanne L. 
Published: February 2019

AbstractThe 2017 Maple Creek earthquake swarm was one of the most prolific swarms to occur in the Yellowstone region in the past few decades, with nearly 2,500 routinely detected earthquakes up toMw4.4 between June and September 2017. To gain insight into the mechanics and underlying mechanisms of this swarm, we enhanced the seismic catalog, detecting and precisely locating nearly 16,000 earthquakes, while estimating magnitudes for more than 30,000 events. We further utilized the cross‐correlation measurements derived from this processing to determine relative polarities for event pairs and to estimate focal mechanisms for the relocated population of events. The results reveal a complex network of faults activated progressively during the swarm, which may reflect diffusion of aqueous fluid pressure through these structures. Fluid‐driven earthquake sequences may naturally generate more complex faulting geometries compared to earthquake sequences dominated by stress transfer.
The Origin of Carbonate Mud
Authors: Trower Elizabeth J. , Lamb Michael P. , Fischer Woodward W. 
Published: February 2019

AbstractCarbonate mudstones are key geochemical archives for past seawater chemistry, yet the origin of carbonate mud remains a subject of continued debate and uncertainty. Prevailing hypotheses have settled on two mechanisms: (1) direct precipitation in the water column and (2) postmortem dispersal of mud‐sized algal skeletal components. However, both mechanisms conflict with geochemical observations in modern systems and are problematic in deep time. We tested the hypothesis that abrasion of carbonate sand during sediment transport might produce carbonate mud using laboratory experiments and a sediment transport model. We documented experimental mud production rates up to two orders f magnitude faster than rates estimated for other mechanisms. Combined with model calculations, these results illustrated that transport and abrasion of carbonate sand is a major source of carbonate mud.
Geochemistry and Geochronology of the Accreted Mafic Rocks From the Hengchun Peninsula, Southern Taiwan: Origin and Tectonic Implications
Authors: Tian Zhi‐Xian , Yan Yi , Huang Chi‐Yue , Zhang Xin‐Chang , Liu Hai‐Quan , Yu Meng‐Ming , Yao Deng , Dilek Yildirim 
Published: February 2019

AbstractThe accretionary prism of the Hengchun Peninsula at the southernmost tip of the active Taiwan orogen has newly emerged due to the transition from a subduction zone to an arc‐continent collision zone. The mafic rocks within the Hengchun accretionary prism, whose provenance has long been controversial, are highly indicative of the mantle nature and tectonic evolution around the northern Manila Trench. Based on geochemical analyses, the accreted basalts are classified as normal and enriched mid‐ocean ridge basalts (N‐MORB and E‐MORB) and alkaline ocean island basalts. The N‐MORBs, which exhibit geochemical signatures indicative of virtually unmetasomatized depleted MORB mantle and yield zircon U‐Pb ages of 22.8 ± 0.3 and 24.2 ± 1.1 Ma, were off‐scraped from the subducted oceanic crust of the South China Sea (SCS). The alkaline ocean island basalts are considered fragments of subducted seamount due to their geochemical similarity with seamount basalts from the SCS. The Hf‐Nd isotopic compositions of basalts from the north SCS may represent the contributions of recycled oceanic crust and the upwelling Hainan Plume. The E‐MORBs, which exhibit similar geochemical compositions as rocks from the Huatung Basin and yield an 40Ar/39Ar age of 135.0 ± 5.6 Ma, were removed from the overriding plate due to the excessive shear stress between the converging plates and were laterally transported by strike‐slip movement; alternatively, they were off‐scraped from the subducted Luzon forearc slices. The temporary uplift and collapse of the accretionary prism caused by seamount subduction may have been responsible for the genesis of the lenticular Shihmen Conglomerate.
Resolving Geophysical Signals by Terrestrial Gravimetry: A Time Domain Assessment of the Correction‐Induced Uncertainty
Authors: Mikolaj M. , Reich M. , Güntner A. 
Published: February 2019

AbstractTerrestrial gravimetry is increasingly used to monitor mass transport processes in geophysics boosted by the ongoing technological development of instruments. Resolving a particular phenomenon of interest, however, requires a set of gravity corrections of which the uncertainties have not been addressed up to now. In this study, we quantify the time domain uncertainty of tide, global atmospheric, large‐scale hydrological, and nontidal ocean loading corrections. The uncertainty is assessed by comparing the majority of available global models for a suite of sites worldwide. The average uncertainty expressed as root‐mean‐square error equals 5.1 nm/s2, discounting local hydrology or air pressure. The correction‐induced uncertainty of gravity changes over various time periods of interest ranges from 0.6 nm/s2 for hours up to a maximum of 6.7 nm/s2 for 6 months. The corrections are shown to be significant and should be applied for most geophysical applications of terrestrial gravimetry. From a statistical point of view, however, resolving subtle gravity effects in the order of few nanometers per square second is challenged by the uncertainty of the corrections.
Proxies for Basement Structure and Its Implications for Mesoproterozoic Metallogenic Provinces in the Gawler Craton
Authors: Motta J. G. , Betts P. G. , de Souza Filho C. R. , Thiel S. , Curtis S. , Armit R. J. 
Published: February 2019

AbstractThe link between mineral resources and crustal‐rooted structures has been proposed for many of the world's most significant mineral provinces. Here we utilize a new approach by interpreting potential field data, including satellite gravity data, and high‐resolution continental‐scale magnetotelluric data, constrained with aeromagnetic, and seismic tomography and reflection data, to determine the distribution of crustal‐scale faults in the Archean to Proterozoic Gawler Craton (South Australia). The eastern flank of the craton hosts the supergiant Olympic Dam iron oxide‐copper‐gold (IOCG) deposit within a larger Olympic IOCG province. The central part of the craton contains gold‐only deposits, which define the Central Gawler Gold province. Both of these provinces are part of a Mesoproterozoic mineral system with an extensive hydrothermal alteration footprint, which formed during complicated tectonic mode switches. We show that both types of mineralization are located in proximity to crustal‐scale structures that appear to connect deep crustal fragments, which likely record the amalgamation of the Archean nucleus of the craton during the Neoarchean with subsequent reworking during the Mesoproterozoic. Many of these structures do not have a surface expression but coincide with gradients in magnetism, gravity, and electric resistivity anomalies, the latter data set suggesting they acted as fluid pathways extending to the lower crust. The results indicate that the first‐order controls on the distribution of IOCG and Central Gawler Gold metallogenic provinces are inherited from earlier tectonic events, which formed major crustal boundaries and related structures that are prone to reworking during later tectonism.
A Global Perspective on Iron and Plankton Through the Tara Oceans Lens
Authors: Marchetti Adrian 
Published: February 2019

AbstractThe Tara Oceans program has delivered major advances in our knowledge of ocean plankton diversity and complexity, shedding light on key interactions that explain their success on a planetary scale. In this issue, Caputi et al. (2019, https://doi.org/10.1029/2018GB006022) further contribute to this knowledge through combining comprehensive bio‐oceanographic genomic and transcriptomic Tara Oceans data sets with iron distributions derived from two global‐scale biogeochemical models. Their findings reveal the prevalence of iron as a limiting nutrient in pelagic ecosystems at both local and global scales, exerting a considerable force that drives plankton evolution and shapes community structure. Integration of omics data (i.e., genomics, transcriptomics, proteomics, and metabolomics) with oceanographic properties and biogeochemical models will transform our view of the ocean ecosystem and its role on a changing planet.
Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options
Authors: van Andel Harmen , Kocemba Kinga A. , Spaargaren Marcel , Pals Steven T. 
Published: February 2019

AbstractAberrant activation of Wnt/β-catenin signaling plays a central role in the pathogenesis of a wide variety of malignancies and is typically caused by mutations in core Wnt pathway components driving constitutive, ligand-independent signaling. In multiple myelomas (MMs), however, these pathway intrinsic mutations are rare despite the fact that most tumors display aberrant Wnt pathway activity. Recent studies indicate that this activation is caused by genetic and epigenetic lesions of Wnt regulatory components, sensitizing MM cells to autocrine Wnt ligands and paracrine Wnts emanating from the bone marrow niche. These include deletion of the tumor suppressor CYLD, promotor methylation of the Wnt antagonists WIF1, DKK1, DKK3, and sFRP1, sFRP2, sFRP4, sFRP5, as well as overexpression of the co-transcriptional activator BCL9 and the R-spondin receptor LGR4. Furthermore, Wnt activity in MM is strongly promoted by interaction of both Wnts and R-spondins with syndecan-1 (CD138) on the MM cell-surface. Functionally, aberrant canonical Wnt signaling plays a dual role in the pathogenesis of MM: (I) it mediates proliferation, migration, and drug resistance of MM cells; (II) MM cells secrete Wnt antagonists that contribute to the development of osteolytic lesions by impairing osteoblast differentiation. As discussed in this review, these insights into the causes and consequences of aberrant Wnt signaling in MM will help to guide the development of targeting strategies. Importantly, since Wnt signaling in MM cells is largely ligand dependent, it can be targeted by drugs/antibodies that act upstream in the pathway, interfering with Wnt secretion, sequestering Wnts, or blocking Wnt (co)receptors.