bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Psychosocial Impacts of Racism on the Development of Black Brazilian Adolescents: Dialogues Based on Vigotski's Historical-Cultural Clinical Psychology
Authors: Oliveira Neto José da Silva , Lima Ana Ignez Belém 
Published: November 2024

Objective: The aim of this study is to analyze the psychosocial implications of racism in the development of black Brazilian adolescents, with the aim of contributing to the construction of theoretical and practical foundations for the work of the cultural-historical clinical psychologist.

Theoretical Framework: This study is based on the Historical-Cultural Psychology of L. S. Vigostki, a Soviet psychologist, and more specifically on the problematizations of Historical-Cultural Clinical Psychology, as well as on discussions and research into Ethnic-Racial Studies.

Method: This is an exploratory study and, more specifically, it was constructed using a Narrative Literature Review, using theoretical and bibliographical references and the research experience in cultural-historical clinical psychology of the Laboratory for the Study of Subjectivity and Mental Health (LADES-UECE) to reflect on the bases for the work of the cultural-historical clinical psychologist with black adolescents.

Results and Discussion: The results show that the experience of racism has profound psychosocial impacts on the psychic dynamics of black adolescents, with three main consequences for the formation of their personality: 1) dysfunctionalization of the cognition-affect unit; 2) disarticulation in the psychological function of concept formation; and, finally, 3) disorganization in the psychic activity of black adolescents. In addition, the results point to the weakness in the training of the cultural-historical clinical psychologist in terms of understanding what racism is, what its impacts are on the psychic development of the black individual, as well as the ability to manage these impacts.

Research Implications: The practical and theoretical implications of this research are that it provides fundamental directions for the work of the cultural-historical clinical psychologist, both on a theoretical level - addressing the construction of clinical reasoning in a psychological approach without much systematization in Brazil - and on a practical level - signaling intervention and management strategies in the face of psychological problems faced by black people in Brazil, especially black adolescents.

Originality/Value: In an original and unprecedented way, this study contributes to the literature in the field of historical-cultural clinical psychology, which is at the beginning of its construction in Brazil. Furthermore, from an ethical-political point of view, the study calls for cultural-historical clinical psychologists to carry out clinical practice in accordance with the philosophical-epistemological foundations of Vygotsky's psychology.
Clogging of Leachate Drains in Landfills due to Biochemical Precipitation: a Literature Review
Authors: Pfeiffer Simone Costa , Carvalho Eraldo Henriques de 
Published: November 2024

Objective: Review the relevant literature and analyze the causes that lead to the clogging of leachate drains in landfills due to biochemical precipitation.

Theoretical Framework: Although leachate drainage systems have greatly evolved in terms of performance, clogging can occur in all designs due to physical, biological, and chemical mechanisms.

Method: To investigate the issue of clogging in leachate drainage systems, an extensive literature review was conducted through consultations on relevant websites. National and international technical papers were sought, as well as regulations from environmental agencies of different countries.

Results and Discussion: The removal of Chemical Oxygen Demand (COD), primarily in the form of acetic acid, transforms this stronger acid into weaker acids such as carbonic acid, which results in an increase in the pH of the environment. The concentration of carbonate also increases, consequently accelerating the precipitation of calcium carbonate. These precipitates are usually mixed with the biofilm and exhibit very characteristic shapes and structures.

Research Implications: The lifespan of a vertical landfill can be strongly determined by the clogging phenomena in the leachate drainage system. Therefore, the monitoring of this system must be carried out with great care.

Originality/Value: This review stands out for addressing a relevant and underexplored topic, especially in the national technical literature. Understanding the processes that can lead to clogging of the leachate drainage system is of interest to everyone working in the field, particularly those who design and/or operate a landfill.
Challenges and Opportunities of The Circular Economy for Sustainability Based on Reverse Logistics
Authors: Silva Valdene Carvalho Peixoto da , Ferreira Filho Hélio Raymundo , Nascimento-e-Silva Daniel 
Published: November 2024

Goal: This article's main objective is to analyze the trends and challenges associated with the circular economy (CE) and reverse logistics (RL), with an emphasis on RL's role as a fundamental component of the CE.

Theoretical framework: The study's theoretical basis focused on the dimensions and analytical categories of the circular economy and reverse logistics as fundamental elements of environmental sustainability. The analysis considered reverse logistics an integral part of the circular economy to identify its challenges and opportunities.

Method and material: The method used was bibliographic. Data were collected from the Google Scholar, Elsevier, and Scielo databases to construct answers to three guiding questions related to a) the trends of the circular economy that allow understanding its integrative vision, the role of reverse logistics in the circular economy, and what are the challenges in implementing the circular economy. Twenty-eight articles on CE and 18 on RL were selected. The definition of the sample considered criteria of relevance, timeliness, and academic impact in articles published in the last fifteen years in high-impact journals. Furthermore, the studies were assessed for their thematic relevance, methodological robustness, and contribution to the development of the field of study. The results were generated using semantic and content analyses.

Results and Conclusion: The results found were that a) the trends of the circular economy are the regeneration of resources as a central priority, design is now occupying a central place in sustainability, and the change from ownership to performance, which structure the new human mentality; b) the role of reverse logistics in the circular economy is to promote sustainability in business in practice, mainly through legal structuring, as is the case of the National Solid Waste Policy (PNRS); and c) the main challenges in implementing the circular economy are the lack of understanding of its principles and the lack of cooperation between organizations, governments and consumers.

Research implications: It is necessary to start legally structuring and practicing reverse logistics now so that the collective mentality can soon collaborate effectively with sustainability.

Originality/value: The study shows that the degree of collaboration between governments, organizations, and consumers is crucial for overcoming the challenges and seizing the opportunities of reverse logistics.
ESTIMATIVA DA RADIAÇÃO SOLAR DIFUSA NA CIDADE DE NATAL – RN EM FUNÇÃO DO INDICE KT
Authors: Santos Cristiano de Assumpção , Feiden Armin , Santos Reginaldo Ferreira , Torres Douglas Guedes Batista , Borio Matheus de Pinho , Guerra Thiago 
Published: November 2024

Objetivo: Este estudo teve como objetivo validar e comparar três modelos de estimativa da radiação solar difusa na cidade de Natal - RN, utilizando dados do Projeto SONDA. Os modelos analisados foram Erbs, Bourges e Page, buscando identificar o mais adequado para as condições climáticas locais.

Referencial Teórico: A radiação solar difusa desempenha um papel crucial no desempenho de sistemas fotovoltaicos. Para otimizar esses sistemas, especialmente em regiões tropicais como Natal - RN, é necessário estimar com precisão as frações de radiação direta e difusa. Modelos precisos de estimativa são essenciais para esse fim.

Método: Dados radiométricos de Natal, fornecidos pelo Projeto SONDA, foram utilizados. A análise comparou os modelos de Erbs (1982), Bourges (1992) e Page (1961), utilizando métricas estatísticas como Erro Médio Absoluto (MBE), Raiz do Erro Quadrático Médio (RMSE), eficiência e variabilidade. A correlação entre o índice de claridade (Kt) e a fração difusa (Kd) foi explorada.

Resultados e Discussão: O modelo de Erbs apresentou maior precisão, com valores mais próximos aos observados, seguido por Bourges, que também mostrou bom desempenho. O modelo Page subestimou consistentemente os valores de radiação difusa, sendo o menos eficaz para Natal - RN. A análise estatística confirmou a adequação dos modelos de Erbs e Bourges para essa localidade.

Implicações da Pesquisa: Os modelos de Erbs e Bourges podem ser aplicados em regiões com condições climáticas semelhantes, auxiliando no planejamento de sistemas solares eficientes.
Autocorrelation and Cross-Correlation of Hospitalizations for Syphilis and HIV/AIDS in the State of Bahia
Authors: Jesus Samuel José Amaral de , Araújo Edna Maria de , Silva Filho Aloísio Machado da 
Published: November 2024

Objective: To identify and estimate the autocorrelation and cross-correlation of time series of hospitalization rates for syphilis and HIV/AIDS in the State of Bahia, in the period from 2000 to 2020.

Theoretical Framework: It is based on the characterization and factors associated with notifications of syphilis and HIV/AIDS infection, as well as the social determinants that influence access to health programs and policies.

Method: This is a time-based ecological study, carried out using data from the Hospital Information System (SIH) and the Brazilian Institute of Geography and Statistics (IBGE). The analyses were performed using the Detrended Fluctuation Analysis (DFA) method and the cross-correlation coefficient ρDCCA.

Results and Discussion: There was persistent behavior for the time series of hospitalizations due to syphilis and HIV/AIDS (αDFA > 0.50), in addition to a weak negative cross-correlation (< -0.20), with only the autocorrelation of syphilis being statistically significant. It is believed that the behavior described tends to occur in the long term and may be repeated in the coming years, if interventions that contribute to the reversal are not carried out, both for the diseases in isolation and for co-infection.

Research Implications: The findings of this research may contribute to updating knowledge about syphilis and HIV/AIDS infection in adults, but mainly to the construction of indicators with an emphasis on health surveillance systems in the State of Bahia.

Originality/Value: The study aims to analyze hospitalization cases in which syphilis or HIV/AIDS was the main diagnosis, thus corroborating the planning and strengthening of public policies.
Adoption of ESG Dimensions in Agribusiness: Impacts on Corporate Management and Sustainability
Authors: Bertuolo Claudemir , Freitas Leninne Guimarães , Pereira Ivone Vieira 
Published: November 2024

Objective: The research aimed to analyze the adoption of ESG (Environmental, Social and Governance) dimensions in Brazilian agribusiness

Methodology: The study methodology consisted of bibliographical research, focused on the analysis of already published sources, such as articles and theses, to understand the adoption of ESG dimensions in agribusiness. Data collection was carried out on academic platforms, such as SciELO and Scopus, using combined descriptors to ensure accuracy in the results. After collection, floating readings were taken.

Results and data analysis: Data analysis revealed that environmental sustainability, ethics in social relations and effective governance are fundamental for the transformation of the agribusiness sector, bringing positive impacts on both business management and long-term sustainability. The results indicate that implementing ESG practices not only improves companies' reputations, but also benefits relationships with stakeholders, including consumers, investors and the community. Furthermore, companies that adopt these practices stand out in terms of competitiveness, as they meet the growing demands of a market that values ​​social and environmental responsibility. Evidence suggests that investments in sustainable technologies and natural resource management can result in operational efficiencies, cost reductions and mitigation of risks associated with environmental and social issues. Ethics in social relations, such as respecting workers' rights and promoting inclusion, strengthens organizational culture and improves productivity. On the other hand, effective governance, with transparency and responsibility, facilitates decision-making and adaptation to emerging regulations, ensuring the resilience of companies in the current scenario.

Conclusion: In conclusion, it is highlighted that the integration of these dimensions is not just a response to external pressures, but an opportunity for innovation and efficiency, contributing to a more sustainable and ethical agribusiness.
Inhibitory Effects of Microalgal Biofilm on Vibrio parahaemolyticus
Authors: Thi Luong Hang Pham , Thang Tran Van , Chi Truong Quynh , Trang Ngo Thi , Nhat Anh Le Van , Khoa Le Van 
Published: November 2024

Microalgae are primary producers, the first trophic level in the food webs of aquatic ecosystems. Therefore, they have many potential applications in aquaculture. This study aimed to create autotrophic biofilms from microalgae strains belonging to the Nostocaceae, Protosiphonaceae, and Scenedesmaceae, isolated in Vietnam and to select a microalgal biofilm capable of inhibiting Vibrio parahaemolyticus. The microalgal biofilms were created by attaching the microalgal strains (cyanobacterium and green algae) to substrates (coconut fibre, sugarcane bagasse and cheesecloth). Additionally, the inhibitory effect of the microalgal biofilm on V. parahaemolyticus was evaluated based on the reduction proportion of V. parahaemolyticus cell numbers in an environment with the microalgal biofilm (co-culture method) compared to those in an environment without microalgal biofilm. The results showed that coconut fibre and cheesecloth had higher coverage density and biomass content of microalgae after 72 hours of biofilm formation than the sugarcane bagasse. We also found that microalgal biofilms formed by the combination of a cyanobacterial strain NK1111 with a green microalgal strain MBN1 or MHN122 reduced 76.2% - 99.8% of V. parahaemolyticus in 96 - 120 hours of co-culture. Meanwhile, microalgal biofilm formed by the strain NK1111 and a green microalgal strain MHB231 inhibited 91.8% of V. parahaemolyticus bacterium as early as 24 hours and inhibited 99.4% of this bacteria at 120 hours of co-culture. Therefore, the microalgal biofilms consisting of the strain NK1111 and the strain MHB231 on cheesecloth or coconut fibre substrate are highly appreciated for their potential application in shrimp farms in Vietnam.
Pityriasis Rubra Pilaris, Refractory to IL-17A Inhibition, with Rapid Improvement Following IL-17A/IL-17F Blockade by Bimekizumab
Authors: Orloff Jeremy , Domzalski Grayson , Amara Shivkar , Lebwohl Mark 
Published: November 2024

Introduction: Pityriasis rubra pilaris (PRP) is a rare inflammatory skin disorder which can severely affect patient quality of life. While there are no FDA-approved therapies for PRP, methotrexate and acitretin are often used as first line treatments. Recent analyses have implicated dysregulation of the IL23/IL17 axis in PRP pathogenesis and the use of biologics for severe cases have been reported in the literature.
Case Report: We report the case of a male in his thirties who presented with PRP refractory to a second course of secukinumab. Physical exam revealed diffuse salmon-colored hyperkeratotic patches coalescing to cover his entire body (BSA >95%). The patient was started on combination therapy with acitretin and bimekizumab. The patient recovered rapidly, with near total resolution of his skin findings four weeks after beginning treatment.
Discussion: Unlike earlier biologics targeting IL-17, bimekizumab has activity on IL-17F in addition to IL-17AF and IL-17A. The efficacy of bimekizumab in this case may signify an important role for IL-17F in PRP pathogenesis. Bimekizumab may offer improved efficacy for the treatment of pityriasis rubra pilaris (PRP) in patients who do not respond to other therapies.
Multiple Injection Site Reactions after Treatment with Different Biologics for Psoriasis and Psoriatic Arthritis
Authors: Domzalski Grayson , Lau William , Barzi Rebecca , Miller Rachel , Lebwohl Mark 
Published: November 2024

Psoriasis (PsO) is an autoimmune disease characterized by erythematous, pruritic, and scaly plaques that can be distributed throughout the body. The development of biologic treatments targeting an array of molecular pathways, including tumor necrosis factor-ɑ or interleukins (IL) 12, 23, 17A, and 17F, has advanced treatment options for these patients. In this article, we report a unique case of a 35-year-old female with 11-year history of PsO and a new onset of guttate PsO following an episode of streptococcal pharyngitis. She was subsequently treated with guselkumab, bimzekizumab, and ixekizumab, developing injection site reactions to each biologic. The patient was suspected to be allergic to polysorbate-80 (PS-80), an aqueous medium to stabilize biologics before administration. Notably, the patient had a negative response to PS-80 on allergy testing, and it remains unclear why the patient experienced ISR with certain medications and not others. Further research is needed to characterize ISR across the different biologics, particularly newer medications being utilized in clinical settings.
Recalcitrant Scalp Psoriasis Successfully Treated with Once-Daily Roflumilast Cream 0.3%
Authors: DOMINGUES ERIK 
Published: November 2024

Scalp psoriasis is a chronic, immune-mediated skin disease with varying phenotypes and is estimated to affect up to 80% of individuals suffering from psoriasis [1]. The physical symptoms, along with social and emotional impacts of scalp psoriasis can significantly reduce quality of life, necessitating long-term treatment for most patients [3]. Numerous topical and systemic treatments are available for scalp psoriasis, yet the condition remains challenging to manage, underscoring a persistent unmet need for safe and effective therapies [2]. Treatment of the scalp and other hair bearing areas is challenging and can affect the ability to apply topical products and hinder their efficacy [2, 3]. Roflumilast cream 0.3% is a highly selective, non-steroidal and potent topical phosphodiesterase 4 (PDE4) inhibitor approved in 2022 by the FDA for the treatment of psoriasis, including intertriginous disease; in 2023 as a foam for the treatment of seborrheic dermatitis and in 2024, roflumilast cream 0.15% was approved for the treatment of atopic dermatitis. Roflumilast has demonstrated a higher affinity for binding to PDE4 relative to other approved PDE4 inhibitors resulting in greater potency [4, 5]. The results of a phase 3 study investigating roflumilast foam 0.3% in patients with scalp and body psoriasis showed that once daily treatment produced significant clearance of affected areas, rapid improvement in pruritus, and was well-tolerated [6]. Here we report a case involving a 28-year-old female with recalcitrant scalp psoriasis following 10 years of unsuccessful treatment with topical products. Due to the severity of adverse effects experienced with prior therapies, the patient was reluctant to initiate systemic therapy and a trial of once daily topical roflumilast cream 0.3% was initiated. The patient demonstrated rapid improvement after 3 days and clearance of the scalp lesion following daily application for 5 days without any reported adverse effects. Lesions on the patient’s torso also cleared. Upon clearance of lesions, the patient discontinued application of roflumilast cream, and lesions remained clear for several weeks and applies only as needed with any recurrence. Our patient’s case demonstrates the significant potential of roflumilast cream 0.3% in addressing the inflammatory etiology of scalp psoriasis.
Maintenance of Response to Risankizumab in Patients With Psoriatic Arthritis: A 4-Year Analysis of the KEEPsAKE 1 and 2 Trials
Authors: Östör Andrew , Glotfelty Lila , Rocco Jonathon , Yue Cuiyong , Merola Joseph F 
Published: November 2024

Introduction: Risankizumab, a humanized immunoglobulin G1 monoclonal antibody, specifically inhibits the p19 subunit of human interleukin 23 and is approved for treatment of active psoriatic arthritis (PsA) in adults. This post hoc analysis evaluated the long-term maintenance of clinical response through ~4 years of risankizumab treatment using data from 2 ongoing phase 3 trials, KEEPsAKE 1 and KEEPsAKE 2.
Methods: Eligible patients had active PsA with inadequate response or intolerance to ≥1 conventional synthetic disease modifying antirheumatic drugs (KEEPsAKE 1 [NCT03675308]; KEEPsAKE 2 [NCT03671148]) and/or inadequate response or intolerance to 1–2 biologic therapies (KEEPsAKE 2 only). Patients received double-blinded risankizumab 150 mg or placebo for 24 weeks and open-label risankizumab 150 mg thereafter. This analysis includes patients who received continuous risankizumab through both treatment periods. Assessments included improvement of ≥20%/50%/70% in PsA symptoms using American College of Rheumatology criteria (ACR20/50/70), achievement of minimal disease activity (MDA), reduction of ≥90% in Psoriasis Area and Severity Index (PASI 90; in patients with ≥3% body surface area affected by psoriasis at baseline), and clinically meaningful reduction in pain (≥10 mm on a visual analog scale [VAS]). All data were reported as observed.
Results: Among patients who achieved ACR20 at week 24 in KEEPsAKE 1 or KEEPsAKE 2, 70.7% and 86.4% maintained ACR20 responses at week 196. Similarly, ACR20 response was maintained to week 196 by 85.7% and 83.3% of week 52 responders in KEEPsAKE 1 and 2, respectively. Similar patterns of maintenance of response were observed for ACR50 and ACR70. Most patients also maintained MDA at week 196 from weeks 24 and 52 (Week 24: KEEPsAKE 1, 86.0%; KEEPsAKE 2, 81.3%; Week 52: KEEPsAKE 1, 81.2%; KEEPsAKE 2, 85.5%). The PASI 90 response was maintained at week 196 from weeks 24 and 52 (Week 24: KEEPsAKE 1, 88.2%; KEEPsAKE 2, 94.9%; Week 52: KEEPsAKE 1, 92.6%; KEEPsAKE 2, 97.1%). Weeks 24 and 52 responders maintained clinically meaningful reductions in pain VAS at week 196 (Week 24: KEEPsAKE 1, 90.2%; KEEPsAKE 2, 88.9%; Week 52: KEEPsAKE 1, 88.3%; KEEPsAKE 2, 90.1%), respectively.
Conclusion: Risankizumab demonstrated durable long-term efficacy in patients with active PsA. A high proportion of patients receiving continuous risankizumab treatment in KEEPsAKE 1 and KEEPsAKE 2 maintained ACR20/50/70, MDA, or PASI90 responses and meaningful pain reduction through week 196.