bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural Characterization ofABCB1, the Gene Underlying thed2Dwarf Phenotype in Pearl Millet,Cenchrus Americanus(L.) Morrone
Authors: Parvathaneni Rajiv K , Spiekerman John J , Zhou Hongye , Wu Xiaomei , Devos Katrien M 
Published: June 2019

AbstractPearl millet is an important food crop in arid and semi-arid regions of South Asia and sub-Saharan Africa and is grown in Australia and the United States as a summer fodder crop. The d2 dwarf germplasm has been widely used in the last half-century to develop high-performing pearl millet hybrids. We previously mapped the d2 phenotype to a 1.6 cM region in linkage group (LG) 4 and identified the ABCB1 gene as a candidate underlying the trait. Here, we report the sequence, structure and expression of ABCB1 in tall (D2D2) and d2 dwarf (d2d2) germplasm. The ABCB1 allele in d2 dwarfs differs from that in tall inbreds by the presence of two different high copy transposable elements, one in the coding region and the second located 664 bp upstream of the ATG start codon. These transposons were present in all d2 dwarfs tested that were reported to be of independent origin and absent in the analyzed wild-type tall germplasm. We also compared the expression profile of this gene in different organs of multiple tall and d2 dwarf inbreds, including the near-isogenic inbreds at the d2 locus, Tift 23B (D2D2) and Tift 23DB (d2d2). Heterologous transformation of the tall (Ca_ABCB1) and the d2 dwarf (Ca_abcb1) pearl millet alleles in the Arabidopsis double mutant abcb1abcb19 showed that the pearl millet D2 but not the d2 allele complements the Arabidopsis abcb1 mutation. Our studies also show the importance of the COOH-terminal 22 amino acids of the ABCB1 protein in either protein function or stability.
A Unified Model for Inclusive Inheritance in Livestock Species
Authors: David Ingrid , Ricard Anne 
Published: June 2019

Abstract
For years, animal selection in livestock species has been performed by selecting animals based on genetic inheritance. However, evolutionary studies have reported that nongenetic information that drives natural selection can also be inherited across generations (epigenetic, microbiota, environmental inheritance). In response to this finding, the concept of inclusive heritability, which combines all sources of information inherited across generations, was developed. To better predict the transmissible potential of each animal by taking into account these diverse sources of inheritance and improve selection in livestock species, we propose the “transmissibility model.” Similarly to the animal model, this model uses pedigree and phenotypic information to estimate variance components and predict the transmissible potential of an individual, but differs by estimating the path coefficients of inherited information from parent to offspring instead of using a set value of 0.5 for both the sire and the dam (additive genetic relationship matrix). We demonstrated the structural identifiability of the transmissibility model, and performed a practical identifiability and power study of the model. We also performed simulations to compare the performances of the animal and transmissibility models for estimating the covariances between relatives and predicting the transmissible potential under different combinations of sources of inheritance. The transmissibility model provided similar results to the animal model when inheritance was of genetic origin only, but outperformed the animal model for estimating the covariances between relatives and predicting the transmissible potential when the proportion of inheritance of nongenetic origin was high or when the sire and dam path coefficients were very different.
Perbandingan Peningkatan Laju Nadi dan MAP antara Laringoskopi Menggunakan Bilah Laringoskop Macintosh dan McCoy
Authors: Hutariyus Andy , Fuadi Iwan , Bisri Dewi Yulianti 
Published: June 2019

Tindakan laringoskopi dan intubasi dapat menyebabkan peningkatan kadar katekolamin di dalam darah sehingga meningkatkan respons hemodinamik seperti takikardia, peningkatan tekanan darah, peningkatan tekanan intrakranial, aritmia, dan perubahan segmen ST. Respons ini bergantung pada seberapa banyak manipulasi di daerah lidah, faring, laring, dan epiglotis pada saat laringoskopi direk. Tujuan penelitian ini membandingkan peningkatan laju nadi dan mean arterial pressure (MAP) antara laringoskopi intubasi menggunakan bilah Macintosh dan McCoy. Metode penelitian ini adalah uji klinis acak terkontrol buta tunggal pada 40 pasien yang menjalani operasi dengan anestesi umum di RSUP Dr. Hasan Sadikin Bandung dari bulan Juli hingga Agustus 2018. Subjek penelitian dibagi menjadi dua kelompok, kelompok MI laringoskopi intubasi dengan Macintosh dan kelompok MC laringoskopi intubasi dengan McCoy. Data hasil penelitian diuji secara statistik menggunakan uji t tidak berpasangan dan Uji Mann-Whitney. Hasil penelitian ini menunjukkan perbedaan laju nadi dan MAP setelah intubasi pada kelompok McCoy lebih rendah dibanding dengan Macintosh pada menit ke-1, menit ke-2,5, dan menit ke-5 dengan perbedaan signifikan (p˂0,05). Simpulan penelitian ini menunjukkan bahwa laringoskopi dengan bilah laringoscop McCoy dapat mengurangi peningkatan laju nadi dan MAP dibanding dengan Macintosh. Comparison between Laryngoscopy Using Macintosh and McCoy Laryngoscope Blades in Increasing Heart Rate and Mean Arterial PressureLaryngoscopy and intubation often increase hemodynamic responses such as tachycardia, increased blood pressure, increased intracranial pressure, arrhythmia, and changes on the ST segment due to increased blood catecholamines. This response depends on how much the tongue, pharynx, larynx, and epiglottis are manipulated during a direct laryngoscopy. This study was a single blinded randomized controlled trial on 40 patients who underwent surgery under general anesthesia in Dr. Hasan Sadikin General Hospital from July to August 2018. Subjects of study were randomly divided into two groups, Macintosh (MI) and McCoy (MC) groups. Data were analyzed using t-test and Mann-Whitney test. Results of this study found that lower heart rate and MAP increases were identified in McCoy group when compared to the Macintosh group in minute 1, minute 2,5, and minute 5 after intubation. Both variables had statistically significant differences (p<0.05). This study concludes that laryngoscopy using McCoy laryngoscope blade was is able to prevent increase in heart rate and MAP compared to Macintosh.
Implementasi Early Warning Score pada Kejadian Henti Jantung di Ruang Perawatan Rumah Sakit Dr. Hasan Sadikin Bandung yang Ditangani Tim Code Blue Selama Tahun 2017
Authors: Subhan Nurul , Giwangkencana Gezy Weita , Prihartono M. Andy , Tavianto Doddy 
Published: June 2019

Angka kejadian henti jantung di rumah sakit sangat bervariasi. Sebagian besar kasus henti jantung didahului oleh penurunan kondisi pasien yang digambarkan dengan gangguan parameter tanda vital. Keberhasilan Early warning score (EWS) dalam menurunkan angka kejadian henti jantung dipengaruhi oleh implementasi yang baik dari instrumen EWS sesuai dengan pedoman yang ditetapkan. Penelitian ini bertujuan melihat implementasi EWS di RSUP Dr. Hasan Sadikin Bandung. Penelitian bersifat deskriptif dengan desain potong lintang menggunakan data rekam medis pasien henti jantung di ruang perawatan yang ditangani oleh tim Code Blue selama tahun 2017, dan dilakukan pada bulan November 2018. Data EWS 6 jam sebelum dan saat henti jantung, serta tindak lanjut yang dilakukan setelah penilaian EWS dicatat. Didapatkan 87 data rekam medis henti jantung yang memenuhi kriteria inklusi dan tidak termasuk eksklusi. Di antaranya, 72% memiliki catatan EWS lengkap, 9% memiliki catatan EWS tidak lengkap, dan 18% tidak memiliki data EWS. Dari 63 data rekam medis yang memiliki data EWS lengkap hanya 21% yang mendapat tindak lanjut yang sesuai dengan standar prosedur operasional EWS. Simpulan penelitian ini adalah implementasi EWS di ruang rawat inap RSUP Dr. Hasan Sadikin belum cukup memuaskan. Tindak lanjut yang dilakukan setelah penilaian EWS belum sesuai dengan standar prosedur operasional EWS yang berlaku.Implementation of Early Warning Score to Patients with In-Hospital Cardiac Arrest in Dr. Hasan Sadikin General Hospital Managed by Code Blue Team Incidence of in-hospital cardiac arrest varies greatly around the world. Most in-hospital cardiac arrests are preceded with physiological deteriorations that manifest as alterations in vital signs. The success of early warning score (EWS) in reducing the incidence of cardiac arrest is influenced by the good implementation of EWS instruments by ward staff in accordance with the guidelines The aim of this study was to assess to what degree EWS was implemented at Dr. Hasan Sadikin General Hospital Bandung. This was a cross sectional descriptive study on patients with in-hospital cardiac arrest managed by the code blue team during 2017 that was conducted in November 2018. EWS 6 hour prior to cardiac arrest event, EWS at the event, and action taken upon finding an abnormal value were obtained from medical records. Eighty seven medical records were included. Of these, 72% medical records had complete EWS data, 9 medical records had incomplete EWS data, and 18% medical records had no EWS recorded. From those 63 medical records with complete EWS recorded, only 21% had been managed correctly according to the EWS guideline. This study concludes that the implementation of EWS in the wards of Dr. Hasan Sadikin General Hospital Bandung has not been completely satisfactorily. Actions taken after EWS assessment are still not accordance with the EWS guideline.
Empiric Therapy with BRAF and MEK Inhibitors in Metastatic Melanoma
Authors: Cann Christopher G. , Tillman Benjamin F. , Davis Elizabeth J. , Johnson Douglas B. 
Published: June 2019

Abstract
BRAF and MEK inhibitors are highly active in the setting of BRAFV600 mutant melanoma. Rarely, patients without previous testing present with fulminant progression necessitating emergent treatment prior to BRAF testing results. The safety and efficacy of empiric treatment in this setting is unclear. Herein, we present two patients treated with empiric BRAF and MEK inhibitors, resulting in dramatic clinical improvement in one patient later found to have a BRAF mutation, and lack of improvement (but no accelerated progression) in a patient lacking this mutation. Empiric BRAF and MEK inhibitor treatment should not be routinely pursued but may be given safely in rare, emergent situations.
Sivaslı Münevver Nakşî Şeyhi Kazancızâde Emin Edîb Efendi’nin Hayatı, Eserleri ve Vahdet-i Vücûd Anlayışı
Authors: Akdağ Eyyup 
Published: June 2019

Kazancızâde Emin Edîb Efendi
Osmanlı Devleti’nin son döneminde yaşamış Sivas’ın yetiştirdiği önemli
münevverlerden biridir. Âile kökleri Buhâra’ya dayanan Emin Edîb Efendi Sivas
Askeri Rüştiyesi’nde uzun yıllar Farsça muallimi ve Osmanlı Mebusan Meclisi’nde
de iki dönem mebus olarak resmî görevde bulunmuştur. Resmî görevlerinin dışında
Nakşbendî tarikatına müntesip mürşîd-i kâmil olan Emin Edîb Efendi’nin
silsilesi şeyhi Muhammed Kemâhî kanalıyla Mevlânâ Hâlid-i Bağdâdî’ye ulaşır.
Emin Edîb Efendi, Muhammed Kemâhî’nin 1313/1896’daki vefâtından sonra yirmi üç
yıl irşad makamında kalmıştır. Emin Edîb Efendi’nin dînî ve tasavvufî
yaklaşımlarının temelinde İmâm Gazâlî,
Abdülkâdir Geylânî, Mevlânâ Celâleddîn-i Rûmî, Muhyiddin
İbnü’l-Arabî, İbnü’l-Fârız, Mahmud
Şebüsterî, Abdurrahman Câmî ve İsmail Hakkı Bursevî gibi tasavvuf alanının
önemli şahısları yer almaktadır. Ekberî irfan geleneğinin yoğun etkisinde kalan
Emin Edîb Efendi ‘vahdet-i vücûd’u manevî eğitimin nihayeti ve tevhidin zirve
mertebesi olarak kabul etmiştir. Şiirlerinde ilâhi aşk ve vahdet-i vücûd neşvesini
yoğun bir şekilde terennüm eden Emin Edîb Efendi sûfî kimliğinin yanısıra
zâhirî ilimlerde de icâzet sahibi bir âlimdir. Bu yönüyle o, zâhir-bâtı,
medrese-tekke ikilemini şahsiyetinde uyumlu hale getirmiştir. Arapça ve
Farsça’ya eser yazacak seviyede vâkıf olan Emin Edîb Efendi bireylerin
eğitimine özel önem vermiş, mürîdânını güzel ahlak anlayışına göre
yetiştirmiştir.
KAMPUNG ISLAMI: PENGARUH PONDOK PESANTREN SURYALAYA DALAM PERKEMBANGAN PERMUKIMAN DI KAMPUNG GODEBAG
Authors: Shan Shan Shan Shan , Pataruka Marwoto 
Published: June 2019

Abstract: Kampung Godebag is a village located in Desa Tanjungkerta, Kecamatan Pagerageung, Kabupaten Tasikmalaya, West Java - Indonesia. Godebag village is famous for its nickname as Kampung Islami, all starting from the building of a mosque that is Nurul Anshar Mosque which is the forerunner to the establishment of Pondok Pesantren Suryalaya. With the establishment of Pondok Pesantren Suryalaya make the environment around the boardingers undergo many changes, in terms of infrastructure, livelihood, habits, social and cultural community. Godebag village becomes thick with Islamic nuances and improvements in the quality of education because of the many built education fasilites by the pesantren, the livelihood of many people who turned into entrepreneurship because of the many opportunities for entrepreneurship to meet the needs of the students at boarding schools and students from out of town. By conducting field surveys to related locations and additional data collection from the internet it can be seen what changes and developments are taking place in Kampung Godebag, the results of the research indicate that many people change their homes as entrepreneurs, especially those on the main access road Kompleks Pendidikan Pondok Pesantren Suryalaya.Keyword: History, Settlement, Islamic Village. Abstrak: Kampung Godebag adalah sebuah kampung yang berada di Desa Tanjungkerta, Kecamatan Pagerageung, Kabupaten Tasikmalaya, Jawa Barat – Indonesia. Kampung Godebag terkenal dengan julukannya sebagai Kampung Islami, semua berawal dari di bangunnya sebuah masjid yaitu Masjid Nurul Anshar yang merupakan cikal bakal terbentuknya Pondok Pesantren Suryalaya. Dengan berdirinya Pondok Pesantren Suryalaya membuat lingkungan di sekitar pesantren mengalami banyak perubahan, dari segi infrastruktur, mata pencaharian, kebiasan, sosial dan budaya masyarakat. Kampung Godebag menjadi kental dengan nuansa islami dan peningkatan dalam kualitas pendidikan karena banyaknya dibangun fasilitas pendidikan oleh pihak pesantren, mata pencaharian masyarakat banyak yang berubah menjadi berwirausaha karena banyaknya peluang berwirausaha untuk memenuhi kebutuhan para santri di pesantren dan pelajar dari luar kota. Dengan melakukan survey lapangan ke lokasi terkait dan pengumpulan data tambahan dari internet dapat diketahui perubahan dan perkembangan apa saja yang terjadi di Kampung Godebag, hasil dari penelitian menyebutkan bahwa banyak dari masyarakat yang merubah rumah tingggal mereka sebagai tempat berwirausaha terutama yang berada di pinggir jalan utama menuju Kompleks Pendidikan Pondok Pesantren Suryalaya.Kata Kunci: Sejarah , Permukiman, Kampung Islami.
Studi Kelayakan Akses Masuk Stadion Kebondalem Kenda
Authors: Kurniati Rina 
Published: June 2019

Abstract:The development of the city is inseparable from the development of increasingly diverse community needs, including sports activities that are now not only as basic needs but also become the lifestyle of the community. These developments require the availability of sports venues with centralized and comfortable facilities. Kendal District Government is developing the Kebondalem Stadium in order to accommodate this development. Kebondalem Stadium is in a strategic location with a main building in the form of a soccer field and other supporting facilities. The purpose of this study is to conduct a study of the feasibility of the Kebondalem t stadium. The method used is a qualitative research method. Data is obtained through field observations and document review. The analysis was carried out by qualitative descriptive analysis of the feasibility of the Kebondalem Stadium. The results of this study indicate that the condition of the Kebondalem Stadium access and parking area is not sufficient to accommodate the activities of the Kebondalem Stadium, so that a design alternative is needed in the form of a new access construction connected to Jl. Soekarno Hatta and the addition of a more adequate parking area.Keywords: Feasibility; Access, Sport Stadium. Abstrak:Perkembangan kota tidak terlepas dari perkembangan kebutuhan masyarakat yang semakin beragam termasuk aktivitas olahraga yang sekarang tidak hanya sebagai kebutuhan dasar akan tetapi juga menjadi gaya hidup masyarakat. Perkembangan tersebut menuntut tersedianya tempat olahraga yang fasilitasnya terpusat dan nyaman. Pemerintah Kabupaten Kendal melakukan pengembangan Stadion Kebondalem agar dapat mewadahi perkembangan tersebut. Stadion Kebondalem berada pada lokasi strategis dengan dilengkapi bangunan utama berupa lapangan sepakbola dan sarana pendukung lainnya. Tujuan penelitian ini yaitu untuk melakukan kajian studi kelayakan stadion kebondalem Kendal. Metode yang digunakan adalah metode penelitian kualitatif. Data diperoleh melalui observasi lapangan dan telaah dokumen. Analisis dilakukan dengan analisis deskriptif kualitatif terhadap kelayakan Stadion Kebondalem. Hasil dari penelitian ini menunjukkan bahwa kondisi akses masuk Stadion Kebondalem dan area parkir belum memadai untuk mewadahi aktivitas Stadion Kebondalem, sehingga diperlukan alternatif perancangan berupa pembangunan akses baru yang terhubung ke Jl. Soekarno Hatta dan penambahan area parkir yang lebih memadai kapasitasnya.Kata Kunci:Kelayakan; Akses; Stadion Olahraga
BAURAN PEMASARAN JASA PENGARUH TERHADAP KEPUASAN KONSUMEN PT. NUSA TONGKAINA WISATA TIRTA (NTWT) MANADO
Authors: Soegoto Agus Supandi 
Published: June 2019

Penelitian ini bertujuan untuk mengetahui pengaruh produk, tempat, harga, promosi, proses, layanan pelanggan dan orang terhadap kepuasan konsumen PT. Nusa Tongkaina Wisata Tirta. Hipotesis penelitian: “diduga strategi bauran pemasaran jasa berpengaruh terhadap kepuasan konsumen”.Metode analisis yang digunakan adalah regresi linear berganda, korelasi berganda, dan koefisien determinasi. Alat uji hipotesis yang digunakan yaitu uji F dan uji t. Penelitian ini menggunakan 50 responden sebagai sampel. Hasil jawaban diolah dengan menggunakan program SPSS.Hasil regresi linear berganda pada model 1 diperoleh persamaan Y= -7,816 + 0,298pro + 0,306hrg + 0,292prm + 0,102tpt + 9,224prs + 3,731lay.pel + 0,121org, model 2 diperoleh persamaan Y = -6,504 + 0,334pro + 0,270hrg + 0,317prm + 0,153tpt + 8,958prs + 4,808lay.pel. Regresi model 3 diperoleh persamaan Y = -6,293 + 0,334pro + 0,277hrg + 0,332prm + 0,169tpt + 8,958prs, dan model 4 diperoleh persamaan Y = -4,054 + 0,328pro + 0,243hrg + 0,362prm + 0, 199tpt. Korelasi (R) pada model 4 sebesar 0,930.Koefisien determinasisebesar 0,866 dapat diartikan bahwa besarnya kontribusi produk, harga, promosi dan tempat terhadap kepuasan konsumen sebesar 86,6 %. Hasil pengujian uji t (parsial), menunjukan thitung untuk variabel produk sebesar 3,523, harga sebesar 2,274, promosi sebesar 3,808, untuk tempat sebesar 2,373 yang keseluruhanya lebih besar ttabel yaitu 1,684 artinya keempat variabel ini berpengaruh terhadap nilai variabel dependen (kepuasan konsumen), Ha diterima. Nilai Fhitung dalam penelitian ini sebesar 72,523 lebih besar dari nilai Ftabel sebesar 2,61 pada a = 0,05 ini berarti Ho ditolak dan Ha diterima. Hal ini menunjukan bahwa variabel produk, harga, promosi dan tempat bersama-sama mempunyai pengaruh yang signifikan terhadap kepuasan konsumen.Perusahaan harus memperhatikan bauran pemasaran jasa dengan elemen-elemenya, dengan penerapan strategi bauran pemasaran jasa yang lebih baik, diharapkan jasa yang mereka jual dapat memberikan kepuasan bagi konsumen, dengan tidak mengabaikan faktor lain yang tidak di teliti dalam penelitian ini.
THE INFLUENCE OF ORGANIZATIONAL CULTURE AND ORGANIZATIONAL COMMITMENT ON EMPLOYEE PERFORMANCE (Study in PT Pelayaran Samudera Selatan Jakarta)
Authors: Muhyi Herwan Abdul 
Published: June 2019

Organizational culture and organizational commitment are the two factors that related to unoptimal employee performance The purpose of this research is to know, firstl; the implementation of organizational culture,organizational commitment, employee performance; and secondly, the influence of organizational culture and organizational commitment on the employee performancet. Variables of this research consist of organizational culture (X1), organizational commitment with subvariables; affective commitment (X2), continuance commitmen (X3), normative commitment (X4). and employee performance (Y).This research use explanatory method to explain causal relation among variables through hipotetical assessment. The population of the research is all employees worked in PT Pelayaran Samudera Selatan Jakarta. All of the employees became respondens of this research. The indicators of organizational culture are based on the Stephen Robbins Theory, organizational commitment indicators adoptedfrom Meyer and Allen Theory, and employee performance based on Bernardin and Russel theory. Generally, it is found that the perception to organizational culture, organizational commitment and employee performance of PT pelayaran Samudera Selatan can be categorized as good. From the path analyses, it is found that the organizational culture and organizational commitment has a strong positive impact either partially or simultancy on the employee performance.
THE INFLUENCE OF TRANSFORMATIONAL LEADERSHIP ON SERVICE COMMITMENT (Survey in Dinas Kependudukan, Catatan Sipil dan Tenaga Kerja at Cirebon City)
Authors: Candradewini Candradewini 
Published: June 2019

The purpose of this research is to know (1) the implementation of transformational leadership; (2) the service commitment; and (3) the influence of transformational leadership on service commitment. There are two research variables, transformational leadership (X) and service commitment (Y).This research use study method with explanatory research to explain causal relation among variables. Address the research objective it is conducted a descriptive and verification analysis by regression analysis as means of its analysis. The research was conducted on whole employees who worked in Dinas Kependudukan, Catatan Sipil dan Tenaga Kerja Cirebon City in which samples is all of its employee. The transformational leadership variable used an indicator whose was suggested by Bass, whereas the service commitment variable used an indicator whose was suggested by Sutopo and Suryanto. Generally, the results of research concluded that transformational leadership which was conducted existing in high category and the service commitment existed in high category too. Using the regression as means of verification analysis indicated that transformational leadership have positive effect on service commitment.
PERAN MEREK, FITUR PRODUK DAN KETERGANTUNGAN PADA PRODUK BERDASARKAN PERBEDAAN GENDER TERHADAP PERILAKU PEMBELIAN (STUDI PADA PENGGUNA SMARTPHONE LOKAL DI BANDUNG)
Authors: Munawar Fansuri 
Published: June 2019

This study examined the influence of the brand, product features and their dependence on the purchasing behavior based on gender differences. Dependent variables in this study were tested by antecedent factors such as social needs, social influence and the convenience of the consumer dependence on smart phones based on gender differences. This study used survey method with simple random sampling was used to collect the questionnaire distributed to 250 students at two universities in Bandung. The data analysis used Stuctural Equation Model (SEM) with AMOS 21 to test the hypothesis. The findings on men and women have differences that can influence the addiction to smart phone, so not all variables could affect reliance on smart phones. The variables that influenced consumer purchase decisions were the product features and the dependent variable, while the brand variable did not affect the local smart phone purchase decision. Keywords: Smart phone, Brand, Product Features, Addiction, Purchase Behavior