bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) in combination with standard of care chemotherapy in primarily untreated chemo naïve upper gi-adenocarcinomas with peritoneal seeding – a phase II/III trial of the AIO/CAOGI/ACO
Authors: Oliver Goetze Thorsten , Al-Batran Salah-Eddin , Pabst Urs , Reymond Marc , Tempfer Clemens , Bechstein Wolf O. , Bankstahl Ulli , Gockel Ines , Königsrainer Alfred , Kraus Thomas , Mönig Stefan P. , Rau Beate , Schwarzbach Matthias , Piso Pompiliu 
Published: June 2018

AbstractBackgroundPeritoneal metastasis is a common and dismal evolution of several gastrointestinal (GI) tumors, including gastric, colorectal, hepatobiliary, pancreatic, and other cancers. The therapy of peritoneal metastasis is largely palliative; with the aim of prolonging life and preserving its quality. In the meantime, a significant pharmacological advantage of intraperitoneal chemotherapy was documented in the preclinical model, and numerous clinical studies have delivered promising clinical results.MethodsThis is a prospective, open, randomized multicenter phase III clinical study with two arms that aims to evaluate the effects of pressurized intraperitoneal aerosol chemotherapy (PIPAC) combined with systemic chemotherapy vs. intravenous systemic chemotherapy alone on patients with metastatic upper GI tumors with a peritoneal seeding. Upper GI-adenocarcinomas originated from biliary tract, pancreas and stomach, or esophago- gastric junction are eligible. Patients in the study are treated with standard of care systemic palliative chemotherapy (mFOLFOX6) vs. PIPAC with intravenous (i.v.) chemotherapy (mFOLFOX6). Patients in first line with first diagnosed peritoneal seeding are eligible. Primary outcome is progression free survival (PFS).ConclusionsPIPAC-procedure is explicit a palliative method but it delivers cytotoxic therapy like in hyperthermic intraperitoneal chemotherapy (HIPEC)-procedure directly to the tumor in a minimally invasive technique, without the need for consideration of the peritoneal-plasma barrier. The technique of PIPAC is minimally invasive and very gentle and the complete procedure takes only round about 45 min and, therefore, optimal in a clearly palliative situation where cure is not the goal. It is also ideal for using this approach in a first line situation, where deepest response should be achieved. The symbiosis of systemic therapy and potentially effective surgery has to be well-planned without deterioration of the patient due to aggressive way of surgery like in cytoreductive surgery (CRS)+HIPEC.Trial registrationEudraCT: 2018-001035-40.
Polish listeners’ perception of vowel inherent spectral change in L2 English
Authors: Schwartz Geoffrey , Dzierla Jerzy 
Published: June 2018

Abstract
This paper describes a perception experiment with Polish listeners involving vowel inherent spectral change (VISC) in L2 English. A forced-choice rhyming task employing the Silent Center (SC) paradigm revealed relatively uniform effects of stimulus type (SC, Initial, Middle, Final) on accuracy across two proficiency groups, despite greater overall accuracy on the part of the more proficient users. Analysis of individual vowel pairs used in the rhyming trials revealed some effects of proficiency on the degree to which formant movement in the stimuli affected identification accuracy. This research contributes to the relatively sparse literature on VISC in L2 acquisition. Phonological considerations underlying the degree of VISC in Polish and English are also discussed.
Opera surtitling in Poland: an uncharted area of AVT?
Authors: Maria Rędzioch-Korkuz Anna 
Published: June 2018

Abstract
Audiovisual translation has become a common subject of a number of scientific articles, special issues of translation journals or conferences. It may seem that this fascinating area of research has been examined thoroughly and may only be investigated further from the point of view of technological improvements in human communication. However, there are certain modalities of AVT which may appear to have been neglected from the scientific point of view. This article is aimed at discussing such a modality of AVT, namely opera surtitling. It concentrates on surtitling strategies employed by Polish opera houses, which are discussed mainly from the point of view of the semiotics of opera and AVT theory. Results of a questionnaire survey on surtitling conducted among operatic audiences are provided to support the discussion. The surtitling strategies as well as particular techniques observed in provided samples are confronted with the accepted practice, which arises from the theoretical prerequisites and seems common to most famous opera houses. It all helps to arrive at the conclusion that this particular AVT modality is a demanding task, requiring both translational and extra-linguistic expertise.
Religionspädagogische Resonanzen in Ost und West: 1968 in transnationaler Perspektive
Authors: Käbisch David 
Published: June 2018

Zusammenfassung:
Die Proteste des Jahres 1968 sind Teil einer längeren Phase politischer Experimente und sozialer Unruhen in der Tschechoslowakei, in Polen und der DDR als auch in Frankreich, den USA und der Bundesrepublik Deutschland. Wie haben diese Entwicklungen das problemorientierte Lernen im Religionsunterricht verändert? Mit den Methoden der transnationalen Religions- und Bildungsforschung sollen in diesem Artikel erste Antworten auf diese Frage erkundet werden. Im Zentrum stehen nicht die offiziellen Beziehungen zwischen den genannten Staaten, sondern die vielfältigen Akteure und Netzwerke, die für einen grenzüberschreitenden Transfer religionspädagogischer Ideen gesorgt haben.
Determination of Pavement Performance Thresholds for Comfortable Riding on Urban Roads
Authors: Kırbaş Ufuk , Karaşahin Mustafa 
Published: June 2018

Abstract
Whole body vibration (WBV) exposure inside vehicles during transportation affects the driver and passengers adversely, particularly in terms of comfort, health, safety, etc. The main causes of the WBV to which the driver and passengers are exposed are the mechanical structure of the vehicle and road pavements. This study aimed to investigate the relationships between the current performance of pavements and ride comfort for standard passenger cars on urban hot mix asphalt–paved roads, and to specify the threshold values for the pavement condition index (PCI) according to comfort criteria recognized by current standards. For this purpose, PCI values were identified according to the PAVER system on road sections with various performance levels. Vibration data in a vertical direction were measured as defined by ISO 2631-1, Mechanical Vibration and Shock – Evaluation of Human Exposure to Whole-Body Vibration – Part 1: General Requirements, inside the vehicle on the driver seat at ride (driving) speeds of 20, 30, 40, and 50 km/h on the same road section. Assessing these measurements according to the method described in the same standard, awz values were calculated. Subsequently, the relationships between PCI and awz for each ride speed were mathematically modeled by employing artificial neural network (ANN) and fuzzy logic methods. With the aid of these mathematical models, comfort thresholds were determined for each ride speed within an interval of 0 to 100 PCI. The ANN approach was found to be more successful than the fuzzy logic in evaluating the data. The results were evaluated comparatively.
Residual Stress Field of a Single Edge Notch Specimen after Laser Shock Peening and Shot Peening Treatment
Authors: Coratella Stefano , Spradlin T. J. , Langer Kristina , Gharghouri Michael A. , Heckenberger U. C. , Hombergsmeier E. 
Published: June 2018

Abstract
Laser shock peening (LSP) is a reliable, repeatable, and successful surface technique for introducing high magnitude, deep compressive residual stresses that can significantly increase the fatigue life of metallic components. However, depending upon how the LSP treatment is applied, the induced residual stresses can result in the undesirable deformation of the part. In this work, traditional shot peening has been applied over LSP as a means to optimize the stress distribution at the surface of a part while constraining deformation. A single edge notch test specimen of AA7075 was laser peened local to the notch region and then shot peened over the entire central region. The resulting residual stress distribution has been characterized using neutron diffraction to measure the stress distribution in the bulk, and it was compared with (1) incremental center hole drilling to measure the stress distribution up to depths of ∼1 mm and (2) near-surface stresses obtained in a previous X-ray diffraction (XRD) study on nominally identical specimens subjected to the same surface treatments. For regions where the two techniques overlap, the residual stresses are in good agreement (within uncertainty). Comparing the bulk stresses obtained from neutron diffraction in this study and XRD data published elsewhere, it can be shown that shot peening applied after LSP has a profound effect on near-surface stresses; however, these effects disappear at depths of ∼0.7 mm or more.
A Dual sgRNA Approach for Functional Genomics inArabidopsis thaliana
Authors: Pauwels Laurens , De Clercq Rebecca , Goossens Jonas , Iñigo Sabrina , Williams Clara , Ron Mily , Britt Anne , Goossens Alain 
Published: June 2018

AbstractReverse genetics uses loss-of-function alleles to interrogate gene function. The advent of CRISPR/Cas9-based gene editing now allows the generation of knock-out alleles for any gene and entire gene families. Even in the model plant Arabidopsis thaliana, gene editing is welcomed as T-DNA insertion lines do not always generate null alleles. Here, we show efficient generation of heritable mutations in Arabidopsis using CRISPR/Cas9 with a workload similar to generating overexpression lines. We obtain for several different genes Cas9 null-segregants with bi-allelic mutations in the T2 generation. While somatic mutations were predominantly generated by the canonical non-homologous end joining (cNHEJ) pathway, we observed inherited mutations that were the result of synthesis-dependent microhomology-mediated end joining (SD-MMEJ), a repair pathway linked to polymerase θ (PolQ). We also demonstrate that our workflow is compatible with a dual sgRNA approach in which a gene is targeted by two sgRNAs simultaneously. This paired nuclease method results in more reliable loss-of-function alleles that lack a large essential part of the gene. The ease of the CRISPR/Cas9 workflow should help in the eventual generation of true null alleles of every gene in the Arabidopsis genome, which will advance both basic and applied plant research.
A Variable Polyglutamine Repeat Affects Subcellular Localization and Regulatory Activity of a Populus ANGUSTIFOLIA Protein
Authors: Bryan Anthony C , Zhang Jin , Guo Jianjun , Ranjan Priya , Singan Vasanth , Barry Kerrie , Schmutz Jeremy , Weighill Deborah , Jacobson Daniel , Jawdy Sara , Tuskan Gerald A , Chen Jin-Gui , Muchero Wellington 
Published: June 2018

Abstract
Polyglutamine (polyQ) stretches have been reported to occur in proteins across many organisms including animals, fungi and plants. Expansion of these repeats has attracted much attention due their associations with numerous human diseases including Huntington’s and other neurological maladies. This suggests that the relative length of polyQ stretches is an important modulator of their function. Here, we report the identification of a Populus C-terminus binding protein (CtBP) ANGUSTIFOLIA (PtAN1) which contains a polyQ stretch whose functional relevance had not been established. Analysis of 917 resequenced Populus trichocarpa genotypes revealed three allelic variants at this locus encoding 11-, 13- and 15-glutamine residues. Transient expression assays using Populus leaf mesophyll protoplasts revealed that the 11Q variant exhibited strong nuclear localization whereas the 15Q variant was only found in the cytosol, with the 13Q variant exhibiting localization in both subcellular compartments. We assessed functional implications by evaluating expression changes of putative PtAN1 targets in response to overexpression of the three allelic variants and observed allele-specific differences in expression levels of putative targets. Our results provide evidence that variation in polyQ length modulates PtAN1 function by altering subcellular localization.
Uneven Distribution of Mutational Variance Across the Transcriptome of Drosophila serrata Revealed by High-Dimensional Analysis of Gene Expression
Authors: Hine Emma , Runcie Daniel E , McGuigan Katrina , Blows Mark W 
Published: June 2018

Abstract
There are essentially an infinite number of traits that could be measured on any organism, and almost all individual traits display genetic variation, yet substantial genetic variance in a large number of independent traits is not plausible under basic models of selection and mutation. One mechanism that may be invoked to explain the observed levels of genetic variance in individual traits is that pleiotropy results in fewer dimensions of phenotypic space with substantial genetic variance. Multivariate genetic analyses of small sets of functionally related traits have shown that standing genetic variance is often concentrated in relatively few dimensions. It is unknown if a similar concentration of genetic variance occurs at a phenome-wide scale when many traits of disparate function are considered, or if the genetic variance generated by new mutations is also unevenly distributed across phenotypic space. Here, we used a Bayesian sparse factor model to characterize the distribution of mutational variance of 3385 gene expression traits of Drosophila serrata after 27 generations of mutation accumulation, and found that 46% of the estimated mutational variance was concentrated in just 21 dimensions with significant mutational heritability. We show that the extent of concentration of mutational variance into such a small subspace has the potential to substantially bias the response to selection of these traits.
Maintenance of Proper Germline Stem Cell Number Requires Adipocyte Collagen in Adult Drosophila Females
Authors: Weaver Lesley N , Drummond-Barbosa Daniela 
Published: June 2018

Abstract
Stem cells reside in specialized niches and are regulated by a variety of physiological inputs. Adipocytes influence whole-body physiology and stem cell lineages; however, the molecular mechanisms linking adipocytes to stem cells are poorly understood. Here, we report that collagen IV produced in adipocytes is transported to the ovary to maintain proper germline stem cell (GSC) number in adult Drosophila females. Adipocyte-derived collagen IV acts through β-integrin signaling to maintain normal levels of E-cadherin at the niche, thereby ensuring proper adhesion to GSCs. These findings demonstrate that extracellular matrix components produced in adipocytes can be transported to and incorporated into an established adult tissue to influence stem cell number.
Élettörténetek konstrukciója a pszichoterápiában: A terápiás ülésen megvalósuló narratív interakció vizsgálata
Authors: Berán Eszter , Unoka Zsolt 
Published: June 2018

Háttér és célkitűzések: A terápiás ülésen a kliens élettörténeti epizódjai a terapeutával közös konstrukciós folyamat során átalakuláson mennek keresztül, újabb elemekkel egészülnek ki, újra íródnak. Ennek az átalakulási folyamatnak fontos eleme a beszélők narratív perspektívájának folyamatos változása, ami a narratív szelf változásához köthető folyamat. A narratív interakciós folyamat egy másik fontos mozzanata, hogy a beszélők befolyásolják egymás nézőpontváltásait. Így a terapeuta saját beszédében – értelmezésiben, kérdéseiben – megvalósított perspektívaváltások hatással lehetnek a kliens nézőpontjának megváltozására. Vizsgálatunk célkitűzése, hogy bemutassuk és terápiás ülések szövegeiből vett részletekkel illusztráljuk ezeket a narratív perspektívaváltások tükrében nyomon követhető terápiás változásokat.
Módszer: Jelen elemzésben használt szövegrészletek a Budapest Pszichoterápiás Adatbázisból valók, ami két pszichoanalitikus terápiát használó páciens-terapeuta páros hangrögzített üléseit tartalmazza. Ezt az adatbázist egy 1,5 évig tartó megfi gyelés során gyűjtöttük össze. A szövegeket CHILDES módszerrel jegyeztük le, majd kódoltuk a szövegekben található perspektívaváltásokat.
Eredmények: Eredményeink illusztrálják azt a feltevésünket, hogy a terapeuta által alkalmazott narratív perspektívaváltások a kliensnél is hasonló perspektívák felvételét idézték elő. Az új perspektívák felvétele során a kliens történetei számára új megközelítésbe kerültek.
Konklúzió: A terapeuta és kliens narratív perspektívaváltásainak követése és elemzése megfelelő módszernek mutatkozik a pszichoterápia során megvalósuló narratív interakció vizsgálatához, valamint segítségével leírható a narratív szelf átalakulásának folyamata is.
A szociofizikai önállóság első színtere: Építészhallgatók és térlaikus egyetemi hallgatók mentális térképábrázolásainak összehasonlítása
Authors: Dúll Andrea , Somogyi Krisztina , Hülber Attila , Brózik Péter , Szabó Julianna 
Published: June 2018

A vizsgálat háttere és céljai: az ember és a terek/tárgyak környezetpszichológiai tranzakciói során tudatosan és nem tudatosuló módon illeszkedés jön létre a környezet és használója között (személy–környezet összeillés). Az egész életen át tartó fejlődésben a személy–környezet tranzakció változásának fontos szerepe van (pszicho-bio kontextuális fejlődés). A helykötődés és a helyidentitás fejlődésmodellje szerint a pszichológiailag fontos helyek beépülnek a személyek (hely)identitásába. A környezetpszichológiai vizsgálatok szerint a gyerekek és a fi atalok számára – az otthon mellett – a kültéri környezeteknek fokozódóan nagy jelentősége van (tranzakcionális téri-idői társas kontinuum). Ehhez illeszkedik a szociofi zikai önállóság bel- és kültéri környezetekben egyaránt vizsgálható környezetpszichológiai, tranzakcionális fogalma, amelyet kutatásunkba környékhasználatra értelmezünk. A kutatások szerint a térhasználat gyerekkori emlékei nem térnek el építészek és nem építészek esetében, viszont a felnőtt építészek képzési tapasztalataik és vizualizációs módszereik segítségével másképp látják és ábrázolják a világot, mint a laikusok. Vizsgálatunk kérdése, hogy a szociofi zikai önállóság kezdetén használt fontos külterek mentális reprezentációját – közvetlenül a kamaszkor után – mi határozza meg inkább: az ezekhez a színterekhez kapcsolódó hétköznapi tapasztalatok vagy a kibontakozó szakmai tértudás?
Módszer: elsőéves építész (kezdő térszakértő) és tanulmányai elején járó nemépítész (kezdő humán szakértő, térlaikus) egyetemi hallgatók első önálló környezethasználatának retrospektív mentális térképeit vizsgáltuk transzdiszciplináris (TD), ötvözött kvalitatív és kvantitatív kutatási stratégiával. A rajzok feldolgozását kollaboratív transzdiszciplináris teammunkában végeztük.
Eredmények: az ábrázolás módja, elemei és relációik szerint két – megfelelően működő – főkategória (képszerű és térképszerű), és ezeken belül több alkategória formálódott meg. A térképszerű ábrázolás vártnál nagyobb arányú alkalmazása azt mutatja, hogy egy énközeli esemény szociofi zikai kontextusa képi kifejezésmódjának – térszakértelemtől függetlenül – inkább ez felel meg.
Következtetésünk, hogy a térszakértők és a térlaikusok térfelfogásának és -ábrázolásának sokszor igazolt eltéréseit érdemes és kívánatos a környezetpszichológiai szakirodalomban általában megszokottnál tágabb kontextusban kezelni és vizsgálni.
Efeitos de exercícios para o sistema vestibular na melhora da tontura e do equilíbrio após acidente vascular encefálico
Authors: Bonadinam Andelize , Guenka Leandro Caetano , Vedana Joeli 
Published: June 2018

O acidente vascular encefálico (AVE) afeta a função dos sistemas sensoriais ocorrendo discrepância nas informações provenientes do sistema vestibular (SV). O SV é responsável pelo equilíbrio sendo resultado da interação de diversos sistemas que mantém o corpo contra a ação da gravidade, ao haver complicações o pacienteterá queixas de vertigens, tonturas e déficit de equilíbrio. A reabilitação vestibular (RV) tem como objetivo restabelecer a manutenção do equilíbrio e sintomas associados por meio de exercícios baseados em adaptação, habituação e substituição. O objetivo deste estudo foi verificar o efeito de exercícios de RV, juntamente com treino de equilíbrio sobre a vertigem e o desequilíbrio após AVE. A amostra foi constituída por 10 pacientes adultos com idade de 50 a 70 anos, com diagnósticos de acidente vascular encefálico isquêmico ou hemorrágicocom tempo de lesão em média de 5 anos. Foi utilizado a Escala de equilíbrio de Berg de Dizziness Handicap Inventory (DHI). Foram observadas melhoras significativas na diminuição dos sintomas de tontura no DHI com média inicial de 49, 2 pontos e a final de 38,2 (P=0,001) e na Escala de Equilíbrio de Berg com média inicial de59 e final de 66 pontos (P=0,03). Os exercícios utilizados de reabilitação vestibular foram relevantes na melhora nos sintomas de tontura e no incremento do equilíbrio, possivelmente através de mecanismos de adaptação, habituação e compensação que induzem a uma neuroplasticidade no sistema nervoso.
MEDICAL AND SOCIAL CHARACTERISTICS OF PATIENTS WITH PARTIAL SECONDARY ADENTITIES, COMPLICATED AND UNCOMPLICATED DENTOFACIAL ANOMALIES
Authors: Akhmedova N. A. 
Published: June 2018

Purpose. To study the medical and social characteristi of pati nts with parti secondary adentiti complicated and uncomplicated dentofacial anomalies.Materials and methods. The study group consisted of 206 pati nts aged 19 to 62 years. The average age of respondents was 40.5 years. The respondents were divided into the main and control groups of the study. The main group of the study consisted of 179 pati nts with parti secondary adenti complicated and uncomplicated dentofacial anomalies, 27 pati ts with dentofacial anomalies were included in the control group of the study.Results. The frequency of requests for dental care of respondents in the main group of the study was revealed: 34% – 2–3 ti s a year, 38.5% – 1 ti a year, 12.3% – 1 ti in several years, 15.1% – very rarely. In control group of the study: 40.7% – 2–3 ti a year, 44.5% – 1 ti a year, 7.4% – 1 ti in several years, 7.4% – very rarely.The main reasons for seeking dental care in the main group of the study: 54,2% – the toothache, bleeding gums, bad breath; 25.1% – the preventi e examinati 27.9% – the decision of the respondent on prostheti for extracted or damaged teeth (of which 6% of respondents have problems with chewing); 15.6% – the decision to correct the bite; 5% the problems with chewing.The main reasons for seeking dental care in the control group of the study: 11% – the toothache, bleeding gums, bad breath, 37% – the preventi e examinati 7.4% – the decision of the Respondent on prostheti of destroyed teeth, 51.9% – the decision to correct the bite.The result of clinical examinati of pati ts: 96.7% of the study group – the presence of signs of overloading of teeth; 81.5% of pati ts of the control group – the presence of signs of overloading of teeth. In the main group of the study revealed a change in the positi of teeth in the dentiti as a result of loss of teeth, occlusion plane violati of 83.2%, 16,8% – were pati ts with removed teeth up to three years ago.Conclusion. Unti treatment of pati ts for dental care in the event of symptoms is among the most important components of a high-level dental morbidity. The main causes and frequency of applicati for dental care, the nature of pati nt complaints, the presence of bad habits, the criteria for selecti treatment and preventi faciliti and other factors have been revealed. In this arti , the medical and social characteristi of pati ts with dentiti defects. Determinati of the medical and social characteristi of pati nts during dental treatment makes it possible for the denti t and orthopedic denti t to assess the main expectati of pati nts, in additi to local dental problems, which allows to achieve positi e stable results of treatment with changes in the positi of teeth and restorati of the integrity of the dentiti