bluuebunny/crossref_metadata_2025_split huggingface dataset:
La santé mentale des jeunes en contexte linguistique minoritaire
Authors: Ndiaye Léna Diamé , Sombié Guipinhali Nathalie 
Published: March 2018

Dans cet article, nous présentons une étude qui visait à cerner la configuration actuelle des services de santé mentale offerts aux jeunes francophones de la région sociosanitaire de Winnipeg et à déterminer le degré d’articulation entre les dispositifs institutionnels et non institutionnels de prise en charge. Une grille d’entrevue semi-structurée a permis de recueillir des données auprès de 15 répondants provenant des organismes de la région sociosanitaire de Winnipeg. Les résultats de l’étude indiquent qu’un nombre très limité d’organismes offre des services de santé mentale en français aux jeunes francophones. L’analyse nous a également montré que la plupart de ces organismes n’entretiennent pas des relations de complémentarité entre eux, mais sont régis par une circularité relationnelle fondée sur des services ponctuels à travers une dualité formelle-informelle.
L’influence de l’identité linguistique et de l’âge sur la représentation sociale des services de santé mentale chez les personnes dites dépressives
Authors: Lévesque Maude , Negura Lilian , Moreau Nicolas , Laflamme-Lagoke Mobolaji 
Published: March 2018

Cet article étudie la représentation sociale des services de santé mentale chez les personnes dites dépressives en contexte francophone minoritaire au Canada. Des entrevues semi-dirigées ont été réalisées auprès de 44 personnes s’identifiant comme francophones et anglophones. Ces dernières proviennent de Moncton, Ottawa, Sudbury et Winnipeg et ont fait l’expérience d’un épisode dépressif. L’analyse lexicographique complétée par l’analyse intégrée de contenu a fait ressortir trois grands schèmes sociocognitifs de la représentation sociale des services, qui agissent sur l’acceptabilité sociale des services de santé mentale chez les personnes francophones vivant en situation minoritaire : 1) la nature impersonnelle des compétences expertes des professionnels de la santé, 2) la facette médicale de l’identité dépressive et 3) la perte perçue du contrôle dans le contexte de soins. L’acceptabilité sociale des services de santé mentale est discutée également en fonction de la configuration de la représentation sociale des services selon l’âge.
Hiérarchisations linguistiques et émergence de fragilités psychosociales
Authors: Bahi Boniface , Mulatris Paulin 
Published: March 2018

Cette contribution analyse les conditions sociolinguistiques structurantes de la fragilité psychosociale des jeunes Franco-Albertains. Trois contextes émergent : l’anglo-dominance, la relation ambivalente avec le Québec et la francophonie non traditionnelle issue des programmes d’immersion ou de l’immigration. L’analyse des données relatives à ces contextes, et en référence aux notions de hiérarchie linguistique et de fragilité psychosociale, révèle des sentiments ambigus de fragilité. Parallèlement à la fragilité, d’autres sentiments se manifestent chez les jeunes Franco-Albertains, telle la résistance qui apparaît comme leur compétence à surmonter l’adversité en s’inspirant de l’histoire de leur famille ou de leur groupe ethnique. Le recours à cette histoire révèle l’insuffisance des appuis psycho-sanitaires institutionnels. Ainsi, le théâtre des variations linguistiques, ou autrement dit, des niveaux de langage, entre jeunes en milieu franco-albertain illustre-il une problématique majeure, celle invitant à rechercher de nouveaux lieux socioculturels et sociolinguistiques de santé mentale.
La santé mentale de jeunes étudiantes franco-ontariennes d’une université bilingue en Ontario
Authors: Benoit Monique , Bell Janine , Lavoie Anne Marise 
Published: March 2018

Une recherche qualitative menée auprès de jeunes étudiantes francophones du nord de l’Ontario a permis de déceler des situations de détresse psychologique amplifiée par la difficulté de faire face à l’usage de la langue française au sein d’une université à vocation bilingue. Est-ce le fait d’une insécurité linguistique et/ou culturelle ? Les étudiantes rencontrées ont montré que la force d’assimilation au bilinguisme s’inscrit dans une double minorisation à la fois linguistique, où la langue québécoise est employée comme une langue standard, et culturelle où les valeurs anglomajoritaires représentent la seule norme culturelle. Cette réalité provoquée par l’isolement tant linguistique que culturel des étudiantes agirait sur la santé mentale et le rendement universitaire de ces jeunes.
Santé mentale et maladies mentales des jeunes francophones de 15 à 24 ans
Authors: Bouchard Louise , Batista Ricardo , Colman Ian 
Published: March 2018

La plupart des maladies mentales apparaissent à l’adolescence ou au début de la vie adulte ; elles influent sur les réussites scolaires, les possibilités et les succès professionnels ainsi que les relations personnelles et peuvent avoir des répercussions tout au long de la vie. Bien que la majorité des jeunes traversent leur adolescence sans problèmes, une proportion suffisamment importante montre toutefois un profil préoccupant dont il faut prendre acte. L’objectif de cet article est de brosser, à partir des données de l’Enquête sur la santé dans les collectivités canadiennes – Santé mentale (ESCC-SM 2012), un portrait de la santé mentale des jeunes francophones de 15 à 24 ans vivant en situation linguistique minoritaire et de le comparer à celui des jeunes francophones vivant au Québec.
Des cercles de lecture au sein d’équipes de hockey au Nouveau-Brunswick : l’expérience des joueurs
Authors: Jolicoeur Manon , Cormier Marianne 
Published: March 2018

Cette étude cherche à comprendre l’expérience de garçons francophones de 9 et 10 ans à travers un projet de cercles de lecture au sein de trois équipes de hockey du Nouveau-Brunswick. Elle met en lumière des éléments qui motivent les participants à s’engager dans cette initiative communautaire : l’intérêt pour les livres proposés, le rôle des parents, l’ascendant de l’entraîneur, les discussions, la pression des pairs, le désir d’améliorer leurs résultats scolaires ainsi que l’intérêt pour la lecture en général. Les résultats obtenus à l’aide d’observations, d’entretiens informels ponctuels, d’entretiens semi-dirigés et d’un journal de bord mènent à penser que ce dispositif peut constituer un moyen très intéressant de remédier au désengagement en lecture ainsi qu’aux difficultés qui en découlent.
Immobilized TiO2 on glass spheres applied to heterogeneous photocatalysis: photoactivity, leaching and regeneration process
Authors: Cunha Deivisson Lopes , Kuznetsov Alexei , Achete Carlos Alberto , Machado Antonio Eduardo da Hora , Marques Marcia 
Published: March 2018

Heterogeneous photocatalysis using titanium dioxide as catalyst is an attractive advanced oxidation process due to its high chemical stability, good performance and low cost. When immobilized in a supporting material, additional benefits are achieved in the treatment. The purpose of this study was to develop a simple protocol for impregnation of TiO2-P25 on borosilicate glass spheres and evaluate its efficiency in the photocatalytic degradation using an oxidizable substrate (methylene blue), in a Compound Parabolic Concentrator (CPC) reactor. The assays were conducted at lab-scale using radiation, which simulated the solar spectrum. TiO2 leaching from the glass and the catalyst regeneration were both demonstrated. A very low leaching ratio (0.03%) was observed after 24 h of treatment, suggesting that deposition of TiO2 resulted in good adhesion and stability of the photocatalyst on the surface of borosilicate. This deposition was successfully achieved after calcination of the photocatalyst at 400 °C (TiO2-400 °C). The TiO2 film was immobilized on glass spheres and the powder was characterized by scanning electron microscopy (SEM), X-ray diffraction and BET. This characterization suggested that thermal treatment did not introduce substantial changes in the measured microstructural characteristics of the photocatalyst. The immobilized photocatalyst degraded more than 96% of the MB in up to 90 min of reaction. The photocatalytic activity decreased after four photocatalytic cycles, but it was recovered by the removal of contaminants adsorbed on the active sites after washing in water under UV-Vis irradiation. Based on these results, the TiO2-400 °C coated on glass spheres is potentially a very attractive option for removal of persistent contaminants present in the environment.
Cellular prion protein and γ-synuclein overexpression in LS 174T colorectal cancer cell drives endothelial proliferation-to-differentiation switch
Authors: Ong Sing-Hui , Goh Kai-Wey , Chieng Cornelius Kwang-Lee , Say Yee-How 
Published: March 2018

Background
Tumor-induced angiogenesis is an imperative event in pledging new vasculature for tumor metastasis. Since overexpression of neuronal proteins gamma-synuclein (γ-Syn) and cellular prion protein (PrPC) is always detected in advanced stages of cancer diseases which involve metastasis, this study aimed to investigate whether γ-Syn or PrPC overexpression in colorectal adenocarcinoma, LS 174T cells affects angiogenesis of endothelial cells, EA.hy 926 (EA).

Methods
EA cells were treated with conditioned media (CM) of LS 174T-γ-Syn or LS 174T-PrP, and their proliferation, invasion, migration, adhesion and ability to form angiogenic tubes were assessed using a range of biological assays. To investigate plausible background mechanisms in conferring the properties of EA cells above, nitrite oxide (NO) levels were measured and the expression of angiogenesis-related factors was assessed using a human angiogenesis antibody array.

Results
EA proliferation was significantly inhibited by LS 174T-PrP CM whereas its telomerase activity was reduced by CM of LS 174T-γ-Syn or LS 174T-PrP, as compared to EA incubated with LS 174T CM. Besides, LS 174T-γ-Syn CM or LS 174T-PrP CM inhibited EA invasion and migration in Boyden chamber assay. Furthermore, LS 174T-γ-Syn CM significantly inhibited EA migration in scratch wound assay. Gelatin zymography revealed reduced secretion of MMP-2 and MMP-9 by EA treated with LS 174T-γ-Syn CM or LS 174T-PrP CM. In addition, cell adhesion assay showed lesser LS 174T-γ-Syn or LS 174T-PrP cells adhered onto EA, as compared to LS 174T. In tube formation assay, LS 174T-γ-Syn CM or LS 174T-PrP CM induced EA tube formation. Increased NO secretion by EA treated with LS 174T-γ-Syn CM or LS 174T-PrP CM was also detected. Lastly, decreased expression of pro-angiogenic factors like CXCL16, IGFBP-2 and amphiregulin in LS 174T-γ-Syn CM or LS 174T-PrP CM was detected using the angiogenesis antibody array.

Discussion
These results suggest that overexpression of γ-Syn or PrPC could possibly be involved in colorectal cancer-induced angiogenesis by inducing an endothelial proliferation–differentiation switch. NO could be the main factor in governing this switch, and modulation on the secretion patterns of angiogenesis-related proteins could be the strategy of colorectal cancer cells overexpressing γ-Syn or PrPC in ensuring this transition.
Low-Value Clinical Practices in Pediatric Trauma Care
Authors: Deshommes Theony , Freire Gabrielle , Yanchar Natalie , Zemek Roger , Beaudin Marianne , Stang Antonia , Weiss Matthew John , Carsen Sasha , Gagnon Isabelle J. , Gabbe Belinda J. , Bérubé Melanie , Stelfox Henry Thomas , Beno Suzanne , Labrosse Melanie , Beaulieu Emilie , Berthelot Simon , Klassen Terry , Turgeon Alexis F. , Lauzier François , Neveu Xavier , Belcaid Amina , Ben Abdeljelil Anis , Tardif Pier-Alexandre , Giroux Marianne , Moore Lynne 
Published: October 2024

ImportanceReducing low-value care has the potential to improve patient experiences and outcomes and decrease the unnecessary use of health care resources. Research suggests that low-value practices (ie, the potential for harm exceeds the potential for benefit) in adult trauma care are frequent and subject to interhospital variation; evidence on low-value practices in pediatric trauma care is lacking.ObjectiveTo estimate the incidence of low-value practices in pediatric trauma care and evaluate interhospital practice variation.Design, Setting, and ParticipantsA retrospective multicenter cohort study in a Canadian provincial trauma system was conducted. Children younger than 16 years admitted to any of the 59 provincial trauma centers from April 1, 2016, to March 31, 2022, were included.Main Outcomes and MeasuresLow-value practices were identified from systematic reviews of clinical practice guidelines on pediatric trauma. The frequencies of low-value practices were evaluated by estimating incidence proportions and cases per 1000 admissions (low if ≤10% and ≤10 cases, moderate if &amp;gt;10% or &amp;gt;10 cases, and high if &amp;gt;10% and &amp;gt;10 cases) were identified. Interhospital variation with intraclass correlation coefficients (ICCs) were assessed (low if &amp;lt;5%, moderate if 5%-20%, and high if &amp;gt;20%).ResultsA total of 10 711 children were included (mean [SD] age, 7.4 [4.9] years; 6645 [62%] boys). Nineteen low-value practices on imaging, fluid resuscitation, hospital/intensive care unit admission, specialist consultation, deep vein thrombosis prophylaxis, and surgical management of solid organ injuries were identified. Of these, 14 (74%) could be evaluated using trauma registry data. Five practices had moderate to high frequencies and interhospital variation: head computed tomography in low-risk children (7.1%; 33 per 1000 admissions; ICC, 8.6%), pretransfer computed tomography in children with a clear indication for transfer (67.6%; 4 per 1000 admissions; ICC, 5.7%), neurosurgical consultation in children without clinically important intracranial lesions (11.6%; 13 per 1000 admissions; ICC, 15.8%), hospital admission in isolated mild traumatic brain injury (38.8%; 98 per 1000 admissions; ICC, 12.4%), and hospital admission in isolated minor blunt abdominal trauma (10%; 5 per 1000 admissions; ICC, 31%).Conclusions and RelevanceIn this cohort study, low-value practices appeared to be frequent and subject to interhospital variation. These practices may represent priority targets for deimplementation interventions, particularly as they can be measured using routinely collected data.
Enhanced Electromagnetic Energy Conversion in an Entropy‐driven Dual‐magnetic System for Superior Electromagnetic Wave Absorption
Authors: Hu Ruizhe , Luo Jingyuan , Wen Huiliang , Liu Chongbo , Peng Jinbin , Xiong Zhiqiang , Wang Dan , Feng Zhaobo , Peng Yuhui , Che Renchao 
Published: October 2024

AbstractThermochemical conversion is a highly effective method for upgrading organic solid wastes into high‐value materials, contributing to carbon neutrality and peak, carbon emission goals. It also serves as a pathway to develop energy‐efficient electromagnetic wave absorbing (EMWA) materials. In this study, fish skin to successfully in situ nitrify Prussian Blue into Fe3N under external thermal driving condition, resulting in high saturation magnetization is utilized. The resulting Fe3N@C demonstrates outstanding EMWA property, achieving a minimum reflection loss of −71.3 dB. Furthermore, by introducing cellulose nanofiber, a portion of the iron nitride is transformed into iron carbide, resulting in Fe3C/Fe3N@C. This composite exhibits enhanced EMWA properties owing to wider local charge redistribution and stronger electronic interactions, achieving an effective absorption bandwidth (EAB) of 6.64 GHz. Electromagnetic simulations and first‐principles calculations further elucidate the EMWA mechanism, and the maximum reduction value of the radar‐cross section reached 37.34 dB·m2. The design of multilayer gradient metamaterials demonstrated an ultra‐broadband EAB of 11.78 GHz. This paper presents an efficient strategy for atomic‐level biomass waste utilization to prepare Fe3N, provides novel insights into the conversion between metal nitrides and metal carbides, and offers a promising direction for the development of advanced EMWA materials.
Cellular Alignment and Matrix Stiffening Induced Changes in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes
Authors: House Andrew , Santillan Anjeli , Correa Evan , Youssef Victoria , Guvendiren Murat 
Published: October 2024

AbstractBiological processes are inherently dynamic, necessitating biomaterial platforms capable of spatiotemporal control over cellular organization and matrix stiffness for accurate study of tissue development, wound healing, and disease. However, most in vitro platforms remain static. In this study, a dynamic biomaterial platform comprising a stiffening hydrogel is introduced and achieved through a stepwise approach of addition followed by light‐mediated crosslinking, integrated with an elastomeric substrate featuring strain‐responsive lamellar surface patterns. Employing this platform, the response of human induced pluripotent stem cell‐derived cardiomyocytes (hIPSC‐CMs) is investigated to dynamic stiffening from healthy to fibrotic tissue stiffness. The results demonstrate that culturing hIPSC‐CMs on physiologically relevant healthy stiffness significantly enhances their function, as evidenced by increased sarcomere fraction, wider sarcomere width, significantly higher connexin‐43 content, and elevated cell beating frequency compared to cells cultured on fibrotic matrix. Conversely, dynamic matrix stiffening negatively impacts hIPSC‐CM function, with earlier stiffening events exerting a more pronounced hindering effect. These findings provide valuable insights into material‐based approaches for addressing existing challenges in hIPSC‐CM maturation and have broader implications across various tissue models, including muscle, tendon, nerve, and cornea, where both cellular alignment and matrix stiffening play pivotal roles in tissue development and regeneration.
Quantitative Characterization of Gene Regulatory Circuits Associated With Fungal Secondary Metabolism to Discover Novel Natural Products
Authors: Xu Xinran , Sun Yanhong , Zhang Anxin , Li Sijia , Zhang Shu , Chen Sijing , Lou Chunbo , Cai Lei , Chen Yihua , Luo Chunxiong , Yin Wen‐Bing 
Published: October 2024

AbstractMicrobial genetic circuits are vital for regulating gene expression and synthesizing bioactive compounds. However, assessing their strength and timing, especially in multicellular fungi, remains challenging. Here, an advanced microfluidic platform is combined with a mathematical model enabling precise characterization of fungal gene regulatory circuits (GRCs) at the single‐cell level. Utilizing this platform, the expression intensity and timing of 30 transcription factor‐promoter combinations derived from two representative fungal GRCs, using the model fungus Aspergillus nidulans are determined. As a proof of concept, the selected GRC combination is utilized to successfully refactor the biosynthetic pathways of bioactive molecules, precisely control their production, and activate the expression of the silenced biosynthetic gene clusters (BGCs). This study provides insights into microbial gene regulation and highlights the potential of platform in fungal synthetic biology applications and the discovery of novel natural products.
Rapid Thermal Shutdown of Deep‐Eutectic‐Polymer Electrolyte Enabling Overheating Self‐Protection of Lithium Metal Batteries
Authors: Zhang Zengqi , Li Gang , Du Xiaofan , Huang Lang , Kang Guohong , Zhang Jianjun , Cui Zili , Liu Tao , Ni Ling , Jin Yongcheng , Cui Guanglei 
Published: October 2024

AbstractSafety concerns and uncontrollable dendrite growths have severely impeded the advancement of lithium‐metal batteries. Herein, a safe deep‐eutectic‐polymer electrolyte with built‐in thermal shutdown capability is proposed by utilizing hydrophobic association of methylcellulose within a novel deep‐eutectic‐solvent. Specifically, at elevated temperatures, methylcellulose chains aggregate to form dense polymer networks due to hydrophobic association and break the solvation structure equilibrium inside the deep‐eutectic system through encapsulating Li+ in polymer matrix, leading to quick solidification of the electrolyte. The solidified electrolyte obstructs Li+ transports and terminates electrochemical processes, protecting LMBs from unstoppable exothermic chain reactions. The accelerating rate calorimeter tests of 1 Ah pouch cells demonstrate that the as‐prepared electrolyte significantly improves the onset self‐heating temperature from 73 °C for conventional electrolytes to 172 °C and prolongs the thermal runaway waiting time more than 20 hours. More impressively, benefiting from its favorable electrochemical performance, this polymer electrolyte enables LiNi0.8Mn0.1Co0.1O2||Li batteries to retain 92% capacity over 200 cycles and LiFePO4||Li batteries to maintain 90% capacity after 500 cycles. This research paves a promising avenue for enhancing both the safety and electrochemical performance of high‐energy‐density LMBs.
ZnO Nanowire Cold Cathode Hemispherical X‐Ray Sources
Authors: Zhang Zhipeng , Zhang Yunyao , Zhang Guofu , Zhan Runze , Deng Shaozhi , Xu Ningsheng , Chen Jun 
Published: October 2024

AbstractCurved or spherical X‐ray sources are significant for use in intraoperative radiotherapy, adaptive static medical imaging, and high‐throughput industrial inspection, but they are hard to achieve using traditional thermionic cathode point electron sources. In this study, copper (Cu)‐doped zinc oxide (ZnO) nanowires grown on a brass substrate with a designed shape are proposed to achieve cold cathode hemispherical X‐ray sources. The strain‐driven solid–liquid growth model of Cu‐doped ZnO nanowires is proposed, and the oxidation temperature‐dependent and time‐dependent growth characteristics are investigated to optimize the morphologies of ZnO nanowire cold cathodes with a typical turn‐on field of 7.36 MV m−1, a maximum current of 12.54 mA (4.93 mA cm−2) and a uniform field emission image with an area of 2.54 cm2. Hemispherical X‐ray sources formed by Cu‐doped ZnO nanowire field emitters grown on spherical brass alloy and an Al thin film transmission anode target deposited on a hemispherical quartz glass are successfully fabricated, achieving an operating voltage of 39 kV, a dose rate of 240 µGyair s−1 and a projection X‐ray imaging resolution of 2.8 lp mm−1, demonstrating their promising use in a variety of applications.
Strength in Numbers: A Giant NIR‐II AIEgen with One‐for‐All Phototheranostic Features for Exceptional Orthotopic Bladder Cancer Treatment
Authors: You Caifa , Zhu Yiqi , Zhu Jun , Xu Zixuan , Liu Qian , Wang Lei , Zhang Weijie , Hou Jianquan , Wang Dong , Zhong Tang Ben 
Published: October 2024

AbstractOne‐for‐all phototheranostics that allows the simultaneous implementations of multiple optical imaging and therapeutic modalities by utilizing a single component, is growing into a sparkling frontier in cancer treatment. Of particular interest is phototheranostic agent with emission in the second near‐infrared (NIR‐II) window. Nevertheless, the practical uses of those conventional NIR‐II agents are severely impeded by their unsatisfactory features including insufficient stability, low synthetic yield, to be extended absorption/ emission wavelengths, and inefficient phototheranostic outcomes. Developing exceptional phototheranostic agents is thus highly desirable yet remains formidably challenging. Herein, we synthesized two novel N‐heteroacenes‐based NIR‐II luminogens, namely 2TT‐PPT and 4TT‐PBPT, by respectively employing pyrene‐fused phenaziothiadiazoles and pyrene‐fused bisphenaziothiadiazoles as acceptor skeletons. There is strength in numbers by increasing the fusing rings in N‐heteroacenes moieties and numbers of appended donors. Compared to less ring‐fused 2TT‐PPT, the giant molecule 4TT‐PBPT shows improved photophysical characteristics, such as enhanced light absorbance, red‐shifted wavelengths, higher brightness, favorable reactive oxygen species (ROS) generation, and elevated photothermal conversion efficiency, which render 4TT‐PBPT nanoparticles excellent fluorescence‐photoacoustic‐photothermal trimodal imaging guided photodynamic‐photothermal synergistic therapy for orthotopic bladder cancer.