bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct clinical characteristics of optic compressive neuropathyassociated with anterior clinoid process pneumatization
Authors: wu mingxing , xu quangang , sun mingming , li yuyu , wei shihui , zhou huanfen 
Published: November 2024

Abstract

Objective
Anterior clinoid process (ACP) pneumatization is an uncommon entity. The goal of the research was to explore the diagnostic characteristics and prognosis of the compressive optic neuropathy (CON) caused by ACP pneumatization.
Methods
Clinical information were retrospectively gathered via those in hospitals diagnosed alongside CON companied with ACP pneumatization at the Neuro-Ophthalmology Department at the Chinese People’s Liberation Army General Hospital from January 2021 to August 2023.
Results
A overall of thirteen sufferers ( three females and ten males, sixteen involved eyes) participated alongside an average age of 34.38 ± 16.12 years. All the eyes were assessed with the ACP pneumatization classification system established by Da Costa:pneumatization Type 0 occurred in 3/26 sides (11.5%), Type 1 in 8/26 sides (30.8%), Type 2a in 8/26 sides (30.8%), Type 2b in 5/26 sides (19.2%), Type 3 in 2/26 sides (7.7%). 69.6% (16/23) eyes had optic compressive neuropathy in these patients.Among the ten patients with bilateral pneumatization, only three induced bilateral compressive optic neuropathy. 37.5%(6/16) eyes with visual field defect as the first symptom. Ultimately, two patients had endoscopic sphenoidotomy and optic canal decompression surgery, resulting in improved visual acuity in the operated eyes.
Conclusions
CON caused by ACP pneumatization can lead to transient visual obscuration, varying degrees of visual field defects and vision loss. HRCT is advised in cases of unexplained vision loss and visual field defects to determine whether or not ACP gasification is occurring. While whether it requires surgery intervention and its effectiveness, still require large-scale research and verification.
Laparoscopic Surgery is Associated with Increased Risk of Postoperative Peritoneal Metastases in T4 Colon Cancer: A Propensity Score Analysis
Authors: Li Shuyuan , Wang Ye , Xin Cheng , Li Shihao , Jiang Wen Di , Zhang Chen Ming , Zhang Wei , Lou Zheng 
Published: November 2024

Abstract

Background
This study aims to evaluate the postoperative safety, long-term survival, and postoperative peritoneal metastases (PPM) rate associated with laparoscopic surgery (LS) for T4 colon cancer.
Materials and methods
After propensity score matching, there were 85 patients in each of the LS and Open surgery groups. The primary outcomes were the 2-year OS, DFS, and PPM rates.
Results
After matching, 85 patients in each of the groups. The LS group had a higher cumulative 2-year peritoneal metastasis rate (13.9% vs. 3.9%, P = .029), while the 2-year OS (83.0% vs. 84.2%, P = .860) and 2-year DFS (70.9% vs. 74.4%, P = .540) showed no significant difference, compared to the open surgery group. The time to resume diet and the postoperative hospitalization in the LS group were shorter. There were no significant difference harvested lymph nodes, time to remove the drainage and gastric tube, and postoperative complications. The multivariate analysis revealed that LS (HR = 10.783, P = .002), postoperative complications (HR = 17.181, P < .001), and pN stage (N1: HR = 5.786, P = .045; N2: HR = 8.579, P = .027, respectively) were all independent risk factors for PPM.
Conclusion
For non-metastatic T4 colon cancer, the LS does not affect postoperative safety and long-term survival. Therefore, it should not be considered an contraindication for locally advanced T4 colon cancer. However, it is crucial to fully recognize the potential risk of increased PPM associated with LS.
Latent-TGF-β has a domain swapped architecture
Authors: Nishimura Stephen , Jin Mingliang , Seed Robert , Shing Tiffany , Cheng Yifan 
Published: November 2024

Abstract

The multifunctional cytokine TGF-b is produced in a latent form (L-TGF-b) where a RGD containing homodimeric prodomain forms a “ring” encircling mature TGF-b, shielding it from its receptors. Thus L-TGF-b must be activated to function, a process driven by dynamic allostery resulting from integrin binding the L-TGF-b RGD motif. Here we provide critical evidence that defines a domain-swapped architecture of L-TGF-b, an essential component in the dynamic allostery mechanism of L-TGF-b activation.
Calibration of Soil Contact Parameters for Planting Sand Shrubs in the Desert Regions of Inner Mongolia
Authors: Zhang Nannan , Pei Chenghui , Zhang Yantang , Cui Shaoyu , Liang Lingzhi , LIU Zhigang 
Published: November 2024

Abstract

This study addresses the need for an accurate and reliable discrete element model to understand the interaction between soil particles and planting mechanisms during the operation of watering drilling machines used for cultivating xerophytic shrubs in the desert regions of Inner Mongolia. Focusing on soil from the northwestern desert of Inner Mongolia, we calibrated the parameters pertinent to desert soil. Through Plackett-Burman experiments, we identified key factors that significantly affect the angle of repose. The range of these significant factors was further refined using steepest ascent experiments. Subsequently, a Box-Behnken experiment was conducted to establish a regression model for these significant factors, aiming to identify the optimal combination. We validated this optimal combination through a blend of simulation and physical experiments. The results reveal that the optimal combination of significant factors, determined from the angle of repose as the response variable, includes a static friction coefficient of soil-soil at 0.442, a rolling friction coefficient of soil-soil at 0.140, and a static friction coefficient of soil-steel at 0.305. By using the opening diameter and effective depth of the drilling machine as measurement benchmarks, the relative errors for the simulation and physical experiments were recorded at 2.9 % and 0.3 %, respectively. These findings affirm the accuracy and reliability of the measured parameters, thereby providing a theoretical foundation for understanding the interaction mechanisms between desert planting machinery and soil.
Healthcare Workers’ Perspectives on Psychosocial Needs of Immigrant Patients with Drug Resistant Tuberculosis
Authors: Storvig Eline , Harstad Ingunn , Iversen Valentina C. , Ehrnström Birgitta 
Published: November 2024

Abstract

Patients with drug resistant tuberculosis in Norway are often from immigrant backgrounds. In addition to undergoing long-term and demanding treatment, many face challenges related to their recent arrival in the country. This study aims to explore healthcare workers' perspective of psychosocial needs of these patients, focusing on challenges such as cultural barriers, communication, and the impact of social and economic conditions on patient adherence and well-being. By addressing these challenges, the study seeks to contribute to improved care strategies for immigrant patients with drug resistant tuberculosis.
Methods: A qualitative research approach was employed, involving 19 semi-structured interviews with healthcare workers; eleven nurses and six physicians, recruited from three university hospitals and primary healthcare of two municipalities. The study used thematic analysis to examine the data, with an emphasis on identifying patterns in participants' experiences and assessments.
Results: Hospital-based participants primarily described the psychosocial needs of patients during hospital isolation, while those working in primary healthcare mainly associated patients' needs with the delivery of tuberculosis medications. All participants emphasized that caring for immigrants with drug resistant tuberculosis involves addressing the diverse needs of individuals, distinguishing between newly arrived refugees, integrated immigrants, and well-educated migrant workers or foreign students. The thematic analysis identified four main themes: Caring for immigrants with diverse backgrounds and needs; The importance of trust and communication; Psychosocial needs during hospital isolation; Are outpatients` psychosocial needs recognized?
Conclusion: Trust in the healthcare system and effective communication emerged as essential for building relationships and addressing patients’ psychosocial needs. These factors underscore the importance of providing tailored, culturally sensitive care to ensure patients' understanding of and adherence to treatment and follow-up. The findings highlight the need to understand the psychosocial needs of both hospitalized patients and outpatients.
Deep generalizable prediction of RNA secondary structure via base pair motif energy
Authors: Zhou S Kevin , Zhu Heqin , Xiong Peng 
Published: November 2024

Abstract

RNA secondary structure plays essential roles in modeling RNA tertiary structure and further exploring the function of non-coding RNAs. Computational methods, especially deep learning methods, have demonstrated great potential and performance for RNA secondary structure prediction. However, the generalizability of deep learning models is a common unsolved issue in the situation of unseen out-of-distribution cases, which hinders the further improvement of accuracy and robustness of deep learning methods. Here we construct a base pair motif library which enumerates the complete space of locally adjacent three-neighbor base pair and records the thermodynamic energy of corresponding base pair motifs through de novo modeling of tertiary structures, and we further develop a deep learning approach for RNA secondary structure prediction, named BPfold, which employs hybrid transformer and convolutional neural network architecture and an elaborately designed base pair attention block to jointly learn representative features and relationship between RNA sequence and the energy map of base pair motif generated from the above motif library. Quantitative and qualitative experiments on sequence-wise datasets and family-wise datasets have demonstrated the great superiority of BPfold compared to other state-of-the-art approaches in both accuracy and generalizability. The significant performance of BPfold will greatly boost the development of deep learning methods for predicting RNA secondary structure and the further discovery of RNA structures and functionalities.
Sero Prevalence of H. Pylori Infection Among Students of Abrar University in Mogadishu-somalia.
Authors: AHMED ABDULRAZAK MOHAMED , Fujeyra Abdalle 
Published: November 2024

Abstract

Background: The bacteria Helicobacter pylori (H. pylori) is one of the most prevalent infections globally. A systematic review conducted recently indicated that half of the entire world population is infected by it. The situation is worse in developing countries, such as Somalia. Thus, this study sought to establish the SERO-PREVALENCE of H. PYLORI among students of Abrar University in Mogadishu, Somalia.
Method: Cross-Sectional Study Design was carried out on students from Abrar University in the period of January 2022 to June 2022. The total number of students recruited for the study was 150. A structured, self-administered questionnaire was developed and used to collect the required data. For specimen collection and identification from students, simple random sampling was applied. In the above process, 3 to 5 mL of venous blood sample was obtained. After 5 minutes of centrifugation, serum was taken and utilized for a H. pylori serological test. Data was captured in the computer, coded and analyzed by SPSS 20 software.
Results: A total of 150 interviews were sought. The average age of the respondent was 20 years. H. pylori infection sero prevalence was 84 (56.4%). Risk increasing factors include: the ‘eating of spicy food’ (AOR 1.33: 95% CI = (2.203–80.692)), the length of sleep at night (AOR 0.011: 95 % CI= (0.001 – 0.110)), and Gender (AOR = 11.236, 95 % CI = 1.921–65.73) was one of the variables significantly associated with H. pylori.
Conclusion: Sero-prevalence for h. pylori infection was found to be high among students of Abrar University. This study aims to contribute to the authorities in the health sector where the findings will help in availing adequate measures to combat the H. pylori infection. Of particular importance, all the confirmed cases of infection with H. pylori must be treated in what is washing able and dry with contact, and provision of enough clean water to the students is highly critical in the prevention of the spread.
Emergency water supply during disasters in Iran: a multi-criteria group decision analysis
Authors: Chavoshian Ali , Hashemi Hassan , Hosseinzadeh Fatemeh , Zamani Sabzi Hamed 
Published: November 2024

ABSTRACT

In the face of diverse and conflicting factors affecting emergency water supply (EWS) decisions, ensuring sufficient drinking water provision for communities emerges as a critical and intricate challenge. Compounding this complexity is the presence of vague and imprecise data, complicating the evaluation and selection process. To tackle these challenges, this study introduces an extended fuzzy multi-criteria group decision-making (FMCGDM) model, leveraging compromise solutions and relative preference relations, specifically tailored for EWS situations. The proposed model employs linguistic variables with multiple experts’ judgements to rate the alternatives versus conflicting criteria and assign weight to these criteria. By utilizing triangular fuzzy numbers, the model effectively handles information imprecision, enabling nuanced evaluations and distinguishing among potential alternatives. Employing a relative preference relation, the model computes distance values between alternatives and ideal or anti-ideal solutions, aiding in decision-making. Finally, the practical application and computational effectiveness of the model are demonstrated through a real-life case study on EWS in Iran. The results show that the mobile water treatment units and packaged water alternatives received the highest score, placing first and second in the order ranking, respectively, while the existing distribution systems were deemed most inappropriate for the EWS situation in the case study.
Differentiating Maternal Angiogenesis Factors between Early and Late Onset Preeclampsia: Higher sflt-1 in Early Onset Preeclampsia, Lower PlGF and Higher sflt-1/PlGF Ratio in Late Onset Preeclampsia
Authors: Serudji Joserizal , Basyir Vaulinne , Fadhillah Tara 
Published: November 2024

Background: Early onset preeclampsia (PE) is considered a fetal disorder that is associated with placental dysfunction. While late onset preeclampsia is considered a maternal disorder that associated with a normal placenta. An imbalance of angiogenesis factors, namely soluble Fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) is not only a strong predictor of PE but can also be a predictor of poor outcomes or adverse complications of PE. This study was conducted to analyze the difference between angiogenesis factor sFlt-1 and PlGF in maternal serum between patients with early and late onset PE. Material and Methods: This was a cross-sectional study involving pregnant women with PE who were ≥18 years old and gestational age >20 weeks had singleton pregnancies. Subjects who had a major morphological abnormality of a fetus diagnosed with USG and chromosomal abnormality of the fetus were be excluded. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were measured using a digital blood pressure measuring instrument. sFlt-1 and PlGF levels were measured using enzyme linked immunosorbent assay (ELISA). Result: This study showed the level of maternal serum sFlt-1 was 7522.95 pg/mL and the level of maternal serum PlGF was 222.25 pg/mL. There was a difference between sflt-1, PlGF, and the sflt-1/PlGF ratio (p=0.00; p=0.00; p=0.00) in early and late onset of PE where at early onset PE was found higher sflt-1 and late-onset PE had lower PlGF and higher sflt-1/PlGF ratio. Conclusion: There are differences in sFlt-1, PlGF, and sFlt-1/PlGF in early and late onset PE, as higher sflt-1 is found in early onset preeclampsia, while lower PlGF and higher sflt-1/PlGF ratio are found in late onset preeclampsia.Keywords: early onset, late onset, preeclampsia, maternal angiogenesis factor, Flt-1, PlGF
O ensino da segurança do paciente oncológico aplicado à enfermagem: uma revisão integrativa da literatura
Authors: Rangel Ana Cristina da Silva , Brum Ana Karine Ramos 
Published: November 2024

Diante da complexidade do cuidado ao paciente oncológico, compreende-se a relevância da enfermagem na promoção da segurança do paciente, e ressalta-se a importância das estratégias de ensino e aprendizagem da segurança do paciente, na formação de profissionais de enfermagem. O objetivo deste estudo foi apresentar as estratégias de ensino e aprendizagem aplicadas à enfermagem, no contexto da oncologia. Trata-se de uma pesquisa exploratório-descritiva, a fim de responder à seguinte pergunta de pesquisa: Que estratégias de ensino e aprendizagem têm sido utilizadas para a promoção da segurança do paciente oncológico? A busca pelos estudos científicos ocorreu nas bases de dados MEDLINE; LILACS; SCOPUS; e ERIC. Após a aplicação dos critérios de inclusão e de exclusão, nove artigos foram eleitos para a análise. Foram encontradas as seguintes estratégias de ensino e aprendizagem, da segurança do paciente oncológico: aprendizagem baseada em problemas; palestras; ensino prático, a partir das rotinas de serviço; tecnologias educacionais digitais; folder, cursos online, e presencial, Fex-Talk e workshops. Destaca-se que apenas um artigo mencionou a segurança do paciente em oncologia. Observou-se a pouca disponibilidade de publicações científicas relacionadas às estratégias de ensino e aprendizagem da segurança do paciente oncológico. Este estudo contribui para o ensino da segurança do paciente oncológico aplicada à enfermagem, diante das estratégias de ensino apresentadas, e reforça a necessidade de desenvolvimento de novas tecnologias educacionais para o ensino da segurança do paciente oncológico, e de mais estudos sobre a temática.
Palavras-Chave: Educação em Enfermagem; Enfermagem Oncológica; Segurança do Paciente; Métodos de Ensino.
Emoções, autoconhecimento e inteligência emocional de profissionais de saúde na assistência direta intensiva a COVID-19
Authors: Silva Beatriz Soares da , Fonseca Paula Isabella Marujo Nunes , Melo Juliana Semião de , Silva Bruna Diana Monteiro Torres da , Farias Evellin Adriane Oliveira , Tavares Larissa Marques 
Published: November 2024

Introdução: Trata-se de estudo de abordagem qualitativa, inspirado na abordagem metodológica da Sociopoética, cujo objetivo geral foi conhecer as emoções vivenciadas pelos profissionais de saúde da linha de frente no enfrentamento da COVID-19 de um hospital universitário/RJ, indicando caminhos para o autoconhecimento e inteligência emocional. Materiais e Métodos: Participaram 35 profissionais de saúde que prestaram assistência a pacientes com diagnóstico COVID-19 positivo, no CTI da unidade mencionada. A produção dos dados ocorreu por: entrevistas semiestruturadas e oficina em grupo, ambas por meio de plataformas digitais. Dados tratados por Análise de Conteúdo de Bardin. Pesquisa aprovada no CEP EEAN/HESFA e HUCFF/UFRJ. Resultados e Discussão: medo, preocupação, pesar, tristeza, alívio, gratidão foram as emoções e características de emoções principais. Principais manejos: conexão com a espiritualidade e lazer. Evidências de inteligência emocional: identificar um propósito no trabalho, praticar o autoconhecimento. Considerações finais: grande aprendizado vivido no período, mesmo tendo emergido majoritariamente emoções negativas. Observou-se construção e fortalecimento da inteligência emocional para lidar melhor com as situações, sobretudo as difíceis. Criou-se produto cartilha sobre a construção da inteligência emocional.
Palavras-chave: Emoções Manifestas; Pessoal de Saúde, Saúde Mental; Enfermagem, COVID-19.
Conhecimento nutricional, estado nutricional e risco metabólico em caminhoneiros que trafegam na BR 116 do Sudoeste da Bahia
Authors: Brito Alane , Cayres Elaine Martins Pinto , Lelis Clara Oliveira , Santos Maria da Conceição Quirino dos , Yarid Sérgio Donha 
Published: November 2024

Objetivo: investigar o conhecimento nutricional, bem como avaliar o estado nutricional e o risco metabólico de caminhoneiros que trafegam na BR 116. Métodos: trata-se de um estudo do tipo descritivo, transversal e quantitativo, realizado no mês de setembro de 2023 com 84 caminhoneiros brasileiros do gênero masculino, maiores de 18 anos. A coleta de dados ocorreu no espaço da fiscalizadora da Polícia Rodoviária Federal (PRF) na BR 116, entre as cidades de Jequié e Vitória da Conquista. Resultados: a amostra foi composta por 84 caminhoneiros, sendo 100% (n=84) do gênero masculino. A idade foi de 23 á 49 anos. O fato de haver uma significância na resposta “não sei” em alguns quesitos, chamou atenção, apesar do público avaliado possuir 46% de indivíduos com Ensino Médio completo, demonstrou insuficiente conhecimento sobre o que seja fibras. Conclusão: o estudo evidencia um grande número de caminhoneiros acima do peso e com risco elevado para o desenvolvimento de doenças cardiovasculares, dislipidemias e diabetes, apontando como fatores impactantes a ergonomia, sedentarismo e hábitos alimentares irregulares e não saudáveis, fortemente associados ao estilo de vida característico da profissão.
Palavras-chave: Avaliação Nutricional; Avaliação da Pesquisa em Saúde; Nutrição dos Grupos Vulneráveis; Caminhoneiros; Equivalente Metabólico.
Diagnostic Potential of NEAT1, hsa-let-7a-5p, and miR-506-3p in Early-stage Parkinson's Disease
Authors: Samareh Ali , Nematollahi Mohammad Hadi , Pourghadamyari Hossein , Meimand Hossein Ali Ebrahimi , Shabani Mohammad , Asadikaram Gholamreza 
Published: November 2024

Background:
Parkinson's disease (PD) is a multifaceted disease that is influenced
by both genetic and environmental parameters. Non-coding RNAs have been
shown to be ideal biomarkers for several diseases, including PD. This study was conducted
to evaluate the expression levels of NEAT1, hsa-let-7a-5p, and miR-506-3p in individuals
with PD to assess their efficacy for early-stage PD diagnosis.

Methods:
Twenty-four patients with PD and 29 healthy individuals participated in this
study. The IntaRNA tool was used to predict potential base pairings between NEAT1
and let-7a-5p, and NEAT1 and miR-506-3p. RT-qPCR was employed to measure the relative
expression of tyrosine hydroxylase (TH), as well as nuclear enriched abundant transcript
1 (NEAT1), hsa-let-7a-5p, and miR-506-3p levels in both groups. The area under
the receiver operating characteristic curve (AUC) was calculated to evaluate the diagnostic
value.

Results:
The PD group exhibited significantly elevated NEAT1 expression levels compared
to the healthy control group. While the PD group exhibited an insignificant decreased
TH expression level relative to the healthy group. Furthermore, the levels of
hsa-let-7a-5p and miR-506-3p expression were seen to be decreased in patients with PD
in comparison to the control group. Integration of NEAT1, hsa-let-7a-5p, and
miR-506-3p levels significantly enhanced diagnostic capabilities and increased the AUC
to 0.9501 (95% confidence interval: 0.8978-1.000, p <]7 .0001).

Conclusions:
The elevated NEAT1 expression and the decreased expression of hsalet-
7a-5p and miR-506-3p in PD patients indicate that these factors might contribute to
the disease's pathogenesis. Combining the ROC curves of NEAT1 and hsa-let-7a-5p
with miR-506-3p showed improved sensitivity and specificity, facilitating more accurate
PD diagnosis. More importantly, they may contribute as promising non-invasive biomarkers
for PD diagnosis.