bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial dysfunction Impairs the Nuclear Pore Complex in Parkinson’s Disease Pathogenesis
Authors: Riaz Zainab , Chang Yuan-Teng , Zenitsky Gary , Jin Huajun , Anantharam Vellareddy , Kanthasamy Arthi , Kanthasamy Anumantha 
Published: November 2024

AbstractThe mislocalization of transcription factors and irregularities in the nuclear envelope of dopaminergic neurons affected by Parkinson’s disease (PD) implicates the nuclear pore in disease pathogenesis. While mitochondrial dysfunction is an integral component of PD pathophysiology, the involvement of channel-forming nucleoporins (Nups) in mitochondrial dysfunction-related neurodegeneration has not been investigated. Here we have identified pathological changes in the levels and distribution of a set of Nups, which are key structural and functional components of the nuclear pore complex, in dopaminergic neuronal models of PD. We observed that mitochondrial dysfunction reduces the expression of these Nups and disrupts the localization of Ran GTPase in both in vitro and in vivo dopaminergic neuron models. Furthermore, the nuclear pore central channel component, Nup62, mislocalizes and accumulates in the cytoplasm of these neurons under mitochondrial stress conditions. Mitochondrial stress also interferes with classical nuclear export of proteins in dopaminergic neural cells. Notably, we observed Nup pathology and Ran gradient loss in nigral dopaminergic neurons of PD patient brains, which highlights the clinical relevance of nuclear pore dysfunction as a disease mechanism. These findings provide direct evidence of the critical role of Nup-related abnormalities in mitochondrial dysfunction-induced degeneration of dopaminergic neurons, ultimately connecting nuclear pore complex and nucleocytoplasmic transport dysregulation to cell death in the development of PD.Graphical Abstract
Two H3K23 histone methyltransferases, SET-32 and SET-21, function synergistically to promote nuclear RNAi-mediated transgenerational epigenetic inheritance inCaenorhabditis elegans
Authors: Zhebrun Anna , Ni Julie Z. , Corveleyn Laura , Roy Siddharth Ghosh , Sidoli Simone , Gu Sam G. 
Published: November 2024

AbstractNuclear RNAi inC. elegansinduces a set of transgenerationally heritable marks of H3K9me3, H3K23me3, and H3K27me3 at the target genes. The function of H3K23me3 in the nuclear RNAi pathway is largely unknown due to the limited knowledge of H3K23 histone methyltransferase (HMT). In this study we identified SET-21 as a novel H3K23 HMT. By taking combined genetic, biochemical, imaging, and genomic approaches, we found that SET-21 functions synergistically with a previously reported H3K23 HMT SET-32 to deposit H3K23me3 at the native targets of germline nuclear RNAi. We identified a subset of native nuclear RNAi targets that are transcriptionally activated in theset-21;set-32double mutant. SET-21 and SET-32 are also required for robust transgenerational gene silencing induced by exogenous dsRNA. Theset-21;set-32double mutant strain exhibits an enhanced temperature-sensitive mortal germline phenotype compared to theset-32single mutant, while theset-21single mutant animals are fertile. We also found that HRDE-1 and SET-32 are required for cosuppression, a transgene-induced gene silencing phenomenon, inC. elegansgermline. Together, these results support a model in which H3K23 HMTs SET-21 and SET-32 function cooperatively to ensure the robustness of germline nuclear RNAi and promotes the germline immortality under the heat stress.
Selective Enhancement of the Interneuron Network and Gamma-Band Power via GluN2C/GluN2D NMDA Receptor Potentiation
Authors: Camp Chad R. , Banke Tue G. , Xing Hao , Yu Kuai , Perszyk Riley E. , Epplin Matthew P. , Akins Nicholas S. , Zhang Jing , Benke Tim A. , Yuan Hongjie , Liotta Dennis C. , Traynelis Stephen F. 
Published: November 2024

AbstractN-methyl-D-aspartate receptors (NMDARs) comprise a family of ligand-gated ionotropic glutamate receptors that mediate a slow, calcium-permeable component to excitatory neurotransmission. The GluN2D subunit is enriched in GABAergic inhibitory interneurons in cortical tissue. Diminished levels of GABAergic inhibition contribute to multiple neuropsychiatric conditions, suggesting that enhancing inhibition may have therapeutic utility, thus making GluN2D modulation an attractive drug target. Here, we describe the actions of a GluN2C/GluN2D-selective positive allosteric modulator (PAM), (+)-EU1180-453, which has improved drug-like properties such as increased aqueous solubility compared to the first-in-class GluN2C/GluN2D-selective prototypical PAM (+)-CIQ. (+)-EU1180-453 doubles the NMDAR response at lower concentrations (< 10 µM) compared to (+)-CIQ, and produces a greater degree of maximal potentiation at 30 µM. Usingin vitroelectrophysiological recordings, we show that (+)-EU1180-453 potentiates triheteromeric NMDARs containing at least one GluN2C or GluN2D subunit, and is active at both exon5-lacking and exon5-containing GluN1 splice variants. (+)-EU1180-453 increases glutamate efficacy for GluN2C/GluN2D-containing NMDARs by both prolonging the deactivation time and potentiating the peak response amplitude. We show that (+)-EU1180-453 selectively increases synaptic NMDAR-mediated charge transfer onto P11-15 CA1stratum radiatumhippocampal interneurons, but is without effect on CA1 pyramidal cells. This increased charge transfer enhances inhibitory output from GABAergic interneurons onto CA1 pyramidal cells in a GluN2D-dependent manner. (+)-EU1180-453 also shifts excitatory-to-inhibitory coupling towards increased inhibition and produces enhanced gamma band power from carbachol-induced field potential oscillations in hippocampal slices. Thus, (+)-EU1180-453 can enhance overall circuit inhibition, which could prove therapeutically useful for the treatment of anxiety, depression, schizophrenia, and other neuropsychiatric disorders.Significance StatementInterneuron dysfunction and diminished GABAergic inhibition in neocortical and hippocampal circuits remains a prominent molecular hypothesis for neuropsychiatric diseases including anxiety, depression, and schizophrenia. Pharmacological agents that boost GABA receptor function have shown utility in various forms of depression and treating symptoms of schizophrenia. Cortical GABAergic interneurons, unlike their excitatory pyramidal cell counterparts, are enriched for the GluN2D subunit of the NMDA receptor. Thus, GluN2D subunit-selective modulation could be a useful therapeutic tool to enhance local inhibition, improving the prognosis for neuropsychiatric diseases for which interneuron dysfunction is prominent and causal to circuit aberration.
The interaction effect of family ownership, board gender and skills on CSR strategy with ESG performance: evidence from ASEAN-5 countries
Authors: Ab Aziz Noor Hidayah , Abdul Latiff Ahmed Razman , Osman Mohammad Noor Hisham , Alshdaifat Sajead Mowafaq 
Published: November 2024

Purpose
This study aims to examine how corporate social responsibility (CSR) strategy impacts environmental, social and governance (ESG) performance in public listed firms across the Association of Southeast Asian Nations (ASEAN)-5 countries. Additionally, it examines the interaction effect of family ownership, board gender diversity and board skills on the relationship.

Design/methodology/approach
This study used a fixed-effect panel regression to analyse 1,212 observations collected from ASEAN-5 public listed firms, covering the years 2017–2022. To address the endogeneity problem, this study used a two-step GMM.

Findings
The findings indicate that the ESG performance of firms in ASEAN-5 countries is significantly and positively influenced by their CSR strategy, suggesting that robust CSR strategies lead to superior ESG performance. Family ownership is found to weaken the positive impact of CSR strategy on ESG performance, indicating that family firms prioritize CSR less. Furthermore, female and skilful boards are more likely to implement effective CSR strategies, as reflected in their improved ESG performance.

Practical implications
This study urges firms, particularly family-owned firms, to enhance their CSR strategy. It also recommends that policymakers integrate gender diversity and a variety of skills into corporate boards, possibly by revising regulatory frameworks and corporate governance guidelines.

Originality/value
The results of this study are novel and specifically tailored for ASEAN firms. To the best of the authors’ knowledge, this study is among the first to examine the roles of board skills, gender diversity and family ownership in the relationship between CSR strategy and ESG performance in the ASEAN context.
Enhancing environmental sustainability through lean construction principles: an industry-based SEM analysis
Authors: Bajjou Mohamed Saad , Chafi Anas 
Published: November 2024

PurposeIn the modern era, the concept of sustainability has become pervasive, permeating various sectors, including the construction industry. Driven by growing environmental concerns, construction organizations are increasingly compelled to seek operational excellence while realigning their practices towards environmental sustainability goals. Hence, this paper investigates the capability of lean construction (LC) principles in enhancing environmental performance (EP) within the construction industry using a structural equation modeling (SEM) approach.Design/methodology/approachThe study employs SEM to explore the relationship between LC components and environmental performance factors in the construction context. This methodology integrates both empirical and qualitative analyses within a structured framework to explore the relationship between LC components and EP factors in the construction context. By collecting and statistically testing data from 307 Moroccan construction companies, the study evaluates the impact of five LC principles – process transparency and standardization, continuous improvement, waste elimination, planning and scheduling and material flow and pull – on four environmental performance indicators: material use, energy consumption, non-product output and pollutant releases.FindingsThe analysis reveals that, among the five LC principles – process transparency and standardization, continuous improvement, waste elimination, planning and scheduling and material flow and pull – the principles of waste elimination and planning and scheduling significantly contribute to environmental improvements. These practices were shown to impact positively four environmental performance indicators: material use, energy consumption, non-product output and pollutant releases.Originality/valueThis research fills a critical gap in empirical studies on the beneficial effects of LC practices on environmental sustainability in the construction industry. It provides theoretical insights and practical recommendations for managers and practitioners to effectively implement LC principles, thereby promoting more efficient and sustainable practices, particularly in developing countries.
Emergence of global value chains as key driver behind industrial development: evidence from participating African countries
Authors: Edo Samson , Osadolor Nneka 
Published: November 2024

Purpose
The purpose of this paper is to examine the role of global value chains (GVC) in industrial development of emerging economies, with particular focus on participating African countries. The findings of this study are expected to provide insight on the need for more developing countries to participate in GVC.

Design/methodology/approach
This study is built upon the neoclassical and endogenous growth theories, which postulate that savings, physical capital and human capital are the fundamental drivers of development in productive sectors of the economy. The investigation, covering the period 1980–2021, is carried out by using the unrestricted error correction model and dynamic ordinary least squares model.

Findings
The results of this study reveal that GVC stands as the dominant factor driving industrial development, compared to savings, physical capital and human capital. The findings, therefore, seem to contradict the postulation of conventional theories. The policy implications of the findings are not far-fetched. First, industrial development in the participating African countries has benefited largely from GVC; hence, it is necessary to encourage more participation. Second, industrial development also benefited from the control variables (savings, physical capital and human capital), hence the need to sustain their complementary role. Thirdly, only three African countries are actively participating in GVC, which suggests that more countries need to join, to facilitate industrial development.

Originality/value
Previous studies have not given adequate attention to African countries that participate in GVC, thus creating a void that needs to be filled. This study, therefore, produced results that are relevant to policy-making on industrial development in African countries.
Research progress of wearable devices in textile field: a bibliometric analysis using VOSviewer, RStudio bibliometrix and CiteSpace software tools
Authors: Xu Tianqi , Wang Min 
Published: November 2024

PurposeThe purpose of this paper is to analyze research trends on “Wearable devices in textile filed” from 2010 to 2023 and determine the important keywords, nations and journals associated with this topic.Design/methodology/approachUtilizing journal literature on wearable devices from the 2010 to 2023 Web of Science (WoS) database, this study employs VOSviewer, biblioshiny of the R software package and the specialized software CiteSpace to generate knowledge graphs for measuring retrieval outcomes.FindingsThe research on wearable devices integrated into textiles between 2010 and 2023 can be divided into three stages: initial slow progress, subsequent rapid advancement and final slow progress, indicating a general rise in the quantity of published material. The terms “fabrication,” “wearable electronics” and “design” are closely linked in this field. China is the most globally networked country in this field, according to the World Collaboration Map. NANO ENERGY ranked first in the number of articles published in journals, with 18 articles and 1,151 citations.Originality/valueThe study identified the present state and research trends in the field of “Wearable devices in textile filed,” offering valuable information for researchers to enhance their understanding of the field’s progress.
Females wanna-be entrepreneurs need empathic heroes
Authors: Bonanni Carole , Stervinou Sandrine , Viglia Giampaolo 
Published: November 2024

PurposeDespite the well-documented importance of empathy and mentoring in entrepreneurship, there is a need for a deeper understanding of how empathy influences individuals’ “willingness to be mentored”.Design/methodology/approachThis paper investigates gender differences in “Willingness to be mentored” based on the mentor’s types of empathy (cognitive vs affective) and entrepreneurship (social vs for-profit). Drawing on the personal identification and the entrepreneurship literature, we measured the respondents’ “Willingness to be mentored” by manipulating the type of empathy and entrepreneurship and comparing its effect between male and female respondents. Primary survey data were collected from master’s degree students in entrepreneurship from diverse business schools. An explanatory qualitative study on female start-uppers complemented the findings.FindingsThe results from the quantitative study show that female respondents prefer to be mentored by an entrepreneur who exhibits some affective empathy rather than only cognitive empathy, with a preference for a social entrepreneur. The qualitative study confirms the evidence. This research contributes to the discussion on developing social capabilities to succeed in new ventures. It extends our understanding of the importance of empathic entrepreneurs as mentors to foster entrepreneurship among women.Originality/valueTheoretically, we demonstrate the existence of a gender difference in “Willingness to be mentored” based on the type of empathy displayed by the entrepreneur. Additionally, we introduce a new construct in the entrepreneurship literature, “Willingness to be mentored”, and differentiate it from “Attitude toward entrepreneurship”.
Why are satisfied buyers not necessarily loyal?
Authors: Pleshko Larry , Dawes John 
Published: November 2024

Purpose
The aim of this study is to identify why some brand buyers are satisfied, but are not necessarily loyal.

Design/methodology/approach
Based on prior literature, this study posits and tests nine potential reasons for why some satisfied buyers are loyal, and others are not. The factors examined are: distribution intensity, familiarity, popularity, customer satisfaction levels, category experience, variety-seeking, service design fit, satisfaction advantages (consumers having higher satisfaction for one brand versus others) and loyalty advantages (consumers showing higher loyalty for one brand versus others). The authors use the context of food retailing, focusing on the fast-food industry in the State of Kuwait.

Findings
The authors find that approximately 70% of fast-food brand users are satisfied, but only 28% of those satisfied users can be classified as highly loyal. While overall, the study finds satisfaction is positively correlated with individual-level buyer loyalty, analysis also finds that brand popularity, overall customer satisfaction levels, experience, variety-seeking, satisfaction advantages and loyalty advantages are factors that explain why many customers are satisfied, but do not have high levels of loyalty.

Originality/value
This study makes a novel and original contribution in assessing a broad range of factors that help explain why many satisfied buyers are not necessarily also loyal. The findings will assist managers to contextualize their firm’s performance on satisfaction and loyalty.
Cross-functional integration between demand and supply processes: a case study about the role of digital technologies
Authors: Lima Francisco Arnaldo Ferraz , Pimenta Marcio Lopes , Fodra Marcelo , Hilletofth Per 
Published: November 2024

PurposeThe objective of this article is to analyze the integration between the internal functions related to demand and supply processes. The studied object was an agribusiness company that uses digital technologies to operate its inbound logistics.Design/methodology/approachA case study was conducted in a global agribusiness company that went through a restructuring process with the implementation of a shared service center. In-depth interviews were conducted with employees from the demand and supply areas. The analysis involved description of cross-functional integration processes from the areas of demand and supply, the identification of technologies from Industry 4.0 present in the activities of those areas and their role in the integration process.FindingsThe analysis revealed the mediating role of technology in cross-functional integration, the presence of new integration factors and their impact on process performance. A framework was developed that describes the relationship between technology and integration factors, their impacts, and the implications for theory and practice.Practical implicationsRegarding this study, the focal company migrated its activities, which were previously isolated and dispersed across branches, to a centralized shared services unit. This research contributes by providing managers with elements to support their investment decisions in technologies that facilitate the integration process, mainly in the areas of planning and execution. It also contributes to the planning of processes, helping managers who are implementing or migrating activities and areas to new management structures.Originality/valueThis paper brings two new assumptions that may guide future investigations about cross-functional integration and its effects on demand and supply integration (DSI): (1) Digital technologies are able to support cross-functional integration in order to provide information integrity, team alignment, agile and assertive decision making within supply and demand processes; (2) Cross-functional integration, mediated by digital technologies, can generate agility and accuracy of information in the demand and supply processes. This accuracy and agility provide improvements in demand and supply process performance metrics, such as predictability, assertiveness, standardization, productivity and response time.
The exemplary PDS partnership award: an overview and review of publications from award recipients
Authors: Polly Drew 
Published: November 2024

PurposeThe National Association for School-University Partnerships ([NASUP], formerly known as the National Association for Professional Development Schools [NAPDS]), annually awards the Exemplary PDS Partnership Award to partnerships who exemplify many or all of the NAPDS Nine Essentials (NAPDS, 2021). This article provides an overview of the Exemplary PDS Award and provides a review of peer-reviewed journal articles published by recipients of the NASUP/NAPDS Exemplary PDS Partnership Award between 2014 and 2024.Design/methodology/approachThis paper uses a basic review of literature.FindingsFindings indicate that most Exemplary PDS Awards between 2014 and 2024 cite the NAPDS Essentials 1 and 4. Essential 1 focuses on PDS partnerships have a comprehensive mission and mutually beneficial partnership that advances teaching, learning, and equity. Essential 4 focuses on innovative practice and reflecting on PDS partnership activities.Originality/valueThis article provides a review of peer-reviewed journal articles published by recipients of the Exemplary PDS Award.
Monitoring the anticorrosion performance of developed epoxy-based paint formulations on metallic surfaces by electrochemical impedance spectroscopy
Authors: Sariogullari Hidayet , Demirkurt Merve , Yılmazer Zeynep 
Published: November 2024

Purpose
This study aims to investigate the impact of varying solid ratios in epoxy-based formulations on their corrosion resistance. The amounts of epoxy resin in the formulations were kept constant, and the behavior of paints with varying filler ratios was compared. It also examines the tensiometric and rheological properties of these formulations.

Design/methodology/approach
Three distinct epoxy-based formulations cured with amine compounds were prepared. The formulations underwent various testing protocols to evaluate their performance: coating tests: coated panels with cross lines were exposed to humidity and corrosive atmospheres. Tensiometric Measurements: Conducted using pendant and sessile drop methods. Rheological characterizations: ıncluded flow tests, oscillatory amplitude sweeps and three-interval thixotropy tests. Corrosion resistance assessment: after the panels were immersed in methanol for one week, measurements were taken using electrochemical impedance spectroscopy. Additional tests: neutral salt spray (NSS) and humidity testing.

Findings
The study observed that the coated panels, after exposure to NSS and humidity testing, demonstrated corrosion resistance within acceptable limits as defined by the ISO 12944-6 standard. Results indicate that the epoxy-based formulations show potential for improvements in paints and coatings, suggesting promising advancements in their anticorrosion performance.

Originality/value
This research provides insights into how the solid ratios in epoxy-based formulations influence their performance, particularly in terms of corrosion resistance, tensiometric and rheological properties. The findings contribute to the development of more effective epoxy resin-based coatings for industrial applications.