bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avian Influenza A (H7N9) and related Internet search query data in China
Authors: Chen Ying , Zhang Yuzhou , Xu Zhiwei , Wang Xuanzhuo , Lu Jiahai , Hu Wenbiao 
Published: July 2019

AbstractThe use of Internet-based systems for infectious disease surveillance has been increasingly explored in recent years. However, few studies have used Internet search query or social media data to monitor spatial and temporal trends of avian influenza in China. This study investigated the potential of using search query and social media data in detecting and monitoring avian influenza A (H7N9) cases in humans in China. We collected weekly data on laboratory-confirmed H7N9 cases in humans, as well as H7N9-related Baidu Search Index (BSI) and Weibo Posting Index (WPI) data in China from 2013 to 2017, to explore the spatial and temporal trends of H7N9 cases and H7N9-related Internet search queries. Our findings showed a positive relationship of H7N9 cases with BSI and WPI search queries spatially and temporally. The outbreak threshold time and peak time of H7N9-related BSI and WPI searches preceded H7N9 cases in most years. Seasonal autoregressive integrated moving average (SARIMA) models with BSI (β = 0.008, p < 0.001) and WPI (β = 0.002, p = 0.036) were used to predict the number of H7N9 cases. Regression tree model analysis showed that the average H7N9 cases increased by over 2.4-fold (26.8/11) when BSI for H7N9 was >  = 11524. Both BSI and WPI data could be used as indicators to develop an early warning system for H7N9 outbreaks in the future.
Mixed copper(ii)–phenanthroline complexes induce cell death of ovarian cancer cells by evoking the unfolded protein response
Authors: Moráň Lukáš , Pivetta Tiziana , Masuri Sebastiano , Vašíčková Kateřina , Walter Franziska , Prehn Jochen , Elkalaf Moustafa , Trnka Jan , Havel Josef , Vaňhara Petr 
Published: July 2019

Abstract
There is an ongoing need for the development of new cancer therapeutics that combine high cytotoxic efficiency with low side effects, and also override resistance to the first-line chemotherapeutics. Copper(ii)–phenanthroline complexes are promising compounds that were shown previously to induce an immediate cytotoxic response over a panel of tumor cell lines in vitro. The molecular mechanism, however, remained unresolved. In this work we performed a thorough study of the copper(ii)–phenanthroline complexes containing different imidazolidine-2-thione ligands in ovarian cancer cells, and revealed that these complexes induce endoplasmic reticulum (ER) stress and subsequently cell death mediated by the unfolded protein response. Alleviation of the ER-stress by tauroursodeoxycholic acid (TUDCA) attenuated the cytotoxic effects. In summary, we have identified a novel, ER-dependent, molecular mechanism mediating cytotoxic effects of copper(ii)–phenanthroline complexes.
The microRNA in ventricular remodeling: the miR-30 family
Authors: Zhang Xiaonan , Dong Shaoyang , Jia Qiujin , Zhang Ao , Li Yanyang , Zhu Yaping , Lv Shichao , Zhang Junping 
Published: July 2019

Abstract
Ventricular remodeling (VR) is a complex pathological process of cardiomyocyte apoptosis, cardiac hypertrophy, and myocardial fibrosis, which is often caused by various cardiovascular diseases (CVDs) such as hypertension, acute myocardial infarction, heart failure (HF), etc. It is also an independent risk factor for a variety of CVDs, which will eventually to damage the heart function, promote cardiovascular events, and lead to an increase in mortality. MicroRNAs (miRNAs) can participate in a variety of CVDs through post-transcriptional regulation of target gene proteins. Among them, microRNA-30 (miR-30) is one of the most abundant miRNAs in the heart. In recent years, the study found that the miR-30 family can participate in VR through a variety of mechanisms, including autophagy, apoptosis, oxidative stress, and inflammation. VR is commonly found in ischemic heart disease (IHD), hypertensive heart disease (HHD), diabetic cardiomyopathy (DCM), antineoplastic drug cardiotoxicity (CTX), and other CVDs. Therefore, we will review the relevant mechanisms of the miR-30 in VR induced by various diseases.
Intraoperative Estimation of the Coupling Efficiency and Clinical Outcomes of the Vibrant Soundbridge Active Middle Ear Implant Using Auditory Brainstem Response Measurements
Authors: Geiger Ute , Radeloff Andreas , Hagen Rudolf , Cebulla Mario 
Published: July 2019

Purpose
This study intraoperatively measured the coupling efficiency of the Vibrant Soundbridge (VSB), with the aim of avoiding revision surgery due to insufficient outcome. This method can also be used to test the integrity of the implant at the end of the implantation surgery and to evaluate aided thresholds. In addition, this method makes it possible to objectively test how well the VSB has been fitted, provide assistance in fitting handicapped patients or children, evaluate hearing degradation, or test for a drop in coupling efficiency before revision surgeries. In order to analyze the feasibility of these new VSB-aided auditory brainstem response (ABR) thresholds, they were compared to behavioral thresholds from the Vibrogram and the preoperative bone conduction thresholds.

Method
The study included 30 patients with mild-to-severe hearing loss implanted with a VSB (VORP503). Intraoperative ABR thresholds during the VSB implantation were recorded using a VSB-optimized chirp stimulus. The new method is compared to the bone conduction threshold of the study sample and the aided Vibrogram thresholds. Speech intelligibility results up to 24 months after surgery are also presented.

Results
A reliable correlation between the bone conduction thresholds and the intraoperative ABRs was found and was higher in comparison to the Vibrogram. Furthermore, speech intelligibility outcomes were stable over time.

Conclusion
ABR measurements can be used intraoperatively to estimate the coupling efficiency of the VSB and test the integrity of the implant at the end of surgery.
A Two-Interval, Forced-Choice, Observer-Based Procedure for Evaluating Hearing Sensitivity in Children With Motor and Developmental Impairments
Authors: Porter Heather L. , Buss Emily , Browning Jenna , Leibold Lori J. 
Published: July 2019

Purpose

It can be challenging to collect reliable behavioral responses to sound from individuals with significant motor or developmental impairments, the most common types of comorbid disability found in children with hearing loss (e.g.,
Gallaudet Research Institute, 2011
). The purpose of this study was to test the feasibility of using a 2-interval, forced-choice, observer-based method for individuals considered to be difficult-to-test using behavioral audiometric assessments.

Method

Participants were 5 children with motor and developmental impairments, ages 5–15 years (
M
= 11.6,
SD
= 4.6). The functional abilities of all participants were greater than 2
SDs
below the mean, as measured by the Vineland-II Parent Caregiver Rating Form. Participants listened to either a male talker saying the word “playground” or a 1000-Hz warble tone, presented via an insert earphone or a sound field speaker. An observer, blind to signal presentation, selected 1 of 2 temporal intervals, determining which contained the signal based only on participant behavior. Criterion was reached when the observer correctly identified the interval containing the signal for 8 of the last 10 trials.

Results
An 80%-correct criterion was met for all participants, suggesting feasibility for use in children with motor or developmental impairment. Two participants were tested using an adaptive tracking procedure; a reliable threshold estimate was obtained for both children. This method offers promise for children who have difficulty performing behavioral audiometric assessments currently in use clinically.
Are Fenestrated Tracheostomy Tubes Still Valuable?
Authors: Pandian Vinciya , Boisen Sarah E. , Mathews Shifali , Cole Therese 
Published: July 2019

Purpose
The purpose of this clinical focus article is to describe the frequency, indications, and outcomes of fenestrated tracheostomy tube use in a large academic institution.

Method
A retrospective chart review was conducted to evaluate the use of fenestrated tracheostomy tubes between 2007 and 2017. Patients were included in the study if they were ≥ 18 years of age and received a fenestrated tracheostomy tube in the recent 10-year period.

Results
Of 2,000 patients who received a tracheostomy, 15 patients had a fenestrated tracheostomy tube; however, only 5 patients received a fenestrated tracheostomy tube at the study institution.
The primary reason why the 15 patients received a tracheostomy was chronic respiratory failure (73%); other reasons included airway obstruction (20%) and airway protection (7%). Thirteen (87%) patients received a fenestrated tracheostomy tube for phonation purposes. The remaining 2 patients received it as a step to weaning. Of the 13 patients who received a fenestrated tracheostomy tube for phonation, only 1 patient was not able to phonate. Nine (60%) patients developed some type of complications: granulation only, 2 (13.3%); granulation and tracheomalacia, 2 (13.3%); granulation and stenosis, 4 (26.7%); and granulation, tracheomalacia, and stenosis, 1 (6.7%).

Conclusions
Fenestrated tracheostomy tubes may assist with phonation in patients who cannot tolerate a 1-way speaking valve; however, the risk of developing granulation tissue, tracheomalacia, and tracheal stenosis exists. Health care providers should be educated on the safe use of a fenestrated tracheostomy tube and other options available to improve phonation while ensuring patient safety.
Translating High-Resolution Manometry From Research to Clinical Practice
Authors: Knigge Molly A. 
Published: July 2019

Purpose
High-resolution manometry (HRM) is a developing evaluation and treatment modality within the scope of speech-language pathology clinical practice. HRM offers pressure measurement over time that can capture details of pharyngeal and upper esophageal sphincter function unattainable with current dysphagia imaging modalities. As the technology is being adapted from esophageal application to use in the pharynx, understanding the strengths and limitations of HRM is paramount to building valid models for clinical use.

Conclusion
This review of HRM translation from research to clinical practice aims to introduce the speech-language pathologist to this novel evaluation and treatment apparatus.
Fabrication of IGBTs using 300 mm magnetic Czochralski substrates
Authors: Schulze Hans‐Joachim , Öfner Helmut , Niedernostheide Franz‐Josef , Lükermann Florian , Schulz Andreas 
Published: July 2019

Up to now the vast majority of insulated gate bipolar transistors (IGBTs) has been produced on silicon (Si) wafers out of the float‐zone (FZ) process. FZ crystals can easily be used for this application, but are only available with a diameter of up to 200 mm. However, the use of wafer substrates with a diameter of 300 mm offers a significant increase in productivity and is therefore the diameter of choice for the high‐volume production of CMOS devices. In order to benefit from this advantage also for the manufacturing of IGBTs, material out of the magnetic Czochralski process, which is available in 300 mm, had to be adapted. Key issues include crystal originated particles, dopant segregation along the crystal axis, and the higher concentration of oxygen. In particular, the implementation of the field‐stop zone by the implantation of protons will lead to the additional formation of hydrogen‐decorated CIOI complexes which can act electrically as donors. However, by an appropriate adjustment of the processing parameters the electrical characteristics of IGBTs on FZ substrates can be well reproduced.
Fabrication of durable haemophobic surfaces on cast acrylic sheets using UV laser micromachining
Authors: Paul Souvik , Mukhopadhyay Saswata , Mandal Soumen , Agarwal Pankaj , Chanda Nripen 
Published: July 2019

A low‐cost, high‐speed micro‐scale patterning procedure for generation of durable blood‐repellent patterns on polymers using continuous wave (CW) ultra‐violet (UV) laser with optical lens arrangement is demonstrated in this work. A laser engraver which can generate patterned structures in the range of 1–300 µm employing a 5 W, 445 nm CW UV laser with collimating lens arrangement was developed for this purpose. Subsequently, cell cast high impact acrylic sheets of 5 cm × 5 cm size were patterned to generate fishbone architecture like microstructures with central structure footprint 71.3 µm, peripheral structure footprint 29.8 µm and peripheral structure spacing of 77.8 µm. The patterned acrylic was evaluated for hydrophobicity and human blood‐repellent nature using a contact angle goniometer. Hardness tests for checking durability of the patterned surfaces for various biomedical applications were conducted using a hardness tester. The tested Vickers hardness of the acrylic patterned sample was 17.41 HV which indicates durability of the fabricated patterns. Maximum static contact angle of 142.3° and minimum roll‐off angle of 11.7° observed for blood on patterned acrylic confirm the haemophobic nature of the fabricated surfaces.
Effects of Pre- and Post-Exercise Cold-Water Immersion Therapy on Passive Muscle Stiffness
Authors: Hüttel Moritz , Golditz Tobias , Mayer Isabel , Heiss Rafael , Lutter Christoph , Hoppe Matthias Wilhelm , Engelhardt Martin , Grim Casper , Seehaus Frank , Forst Raimund , Hotfiel Thilo 
Published: July 2019

Abstract
Background Cold-water immersion (CWI) has become a popular preventive, regenerative and performance-enhancing intervention in various sports. However, its effects on soft tissue, including changes of intramuscular stiffness, are poorly understood. The purpose of this study was to investigate the effect of CWI on muscle stiffness.
Patients/Material and Methods Thirty healthy participants were included and divided into the three following groups (n = 10): 1) post-ESU group: exercise and CWI (post-exercise set-up); 2) control group: exercise without CWI (control condition); 3) pre-ESU group: CWI alone (pre-exercise set-up). Acoustic radiation force impulse (ARFI) elastography was conducted to assess tissue stiffness (shear wave velocity, SWV). Values obtained at resting conditions (baseline, t0) were compared to values post-exercise (t1, for post-ESU group and control group), post-CWI (t2, for post-ESU group and pre-ESU group; rest for control group) and to 60-min follow-up time (t3, for all groups). Data were assessed in superficial and deep muscle tissue (rectus femoris muscle, RF; vastus intermedius muscle, VI).
Results For the post-ESU group (CWI post-exercise), there was no significant difference between the time points of measurements: exercise (t1: RF: 1.63 m/s; VI: 1.54 m/s), CWI (t2: RF: 1.63 m/s; VI: 1.53 m/s) and at 60-min follow-up (t3: RF: 1.72 m/s; VI: 1.61 m/s). In the control group, a significant decrease of SWV was found between baseline conditions at t0 and post-exercise (t1) at VI (VI: 1.37 m/s; p = 0.004; RF: 1.59 m/s; p = 0.084). For t2 and t3, no further significant changes were detected. Regarding the pre-exercise set-up (pre-ESU group), a significant decrease in SWV from baseline to t2 in VI (1.60 m/s to 1.49 m/s; VI: p = 0.027) was found.
Conclusion This study shows varying influences of CWI on muscle stiffness. Overall, we did not detect any significant effects of CWI on muscle stiffness post-exercise. Muscle stiffness-related effects of CWI differ in the context of a pre- or post-exercise condition and have to be considered in the implementation of CWI to ensure its potential preventive and regenerative benefits.
Die berufsdermatologische Begutachtung
Authors: Elsner P. 
Published: July 2019

ZusammenfassungDie Begutachtung ist neben der Prävention, der Diagnostik und der Therapie wesentlicher Teil des Spektrums der Aufgaben des Berufsdermatologen. Sie setzt neben fundierten dermatologischen und allergologischen Kenntnissen spezielles Wissen zum Berufskrankheitenrecht voraus. Als berufsdermatologischer Gutachter ist ein Arzt nicht kurativ tätig, sondern unterstützt den Träger einer gesetzlichen Unfallversicherung oder ein Sozialgericht in der Ermittlung rechtlich wesentlicher Sachverhalte. Die gutachterliche Neutralität erfordert es, mögliche Befangenheiten zu erkennen und zu vermeiden. Die „Bamberger Empfehlungen“ der Arbeitsgemeinschaft für Berufs- und Umweltdermatologie (ABD) unterstützen die Qualitätssicherung in der berufsdermatologischen Begutachtung ebenso wie die Seminare und Qualitätszirkel zum Erwerb und Erhalt des ABD-Zertifikats „Berufsdermatologie“.
Effektivität von Oberkörperkompressionsbekleidung unter Wettkampfbedingungen. Eine randomisierte Crossover-Studie an Elite-Kanusportlern mit einer zusätzlichen Einzelfallanalyse
Authors: Grim Casper , Hotfiel Thilo , Engelhardt Martin , Drieschner Dennis B. , Willscheid Gernot , Hoppe Matthias W. 
Published: July 2019

ZusammenfassungZiel der Studie war es zu untersuchen, ob im Elite-Kanusport durch das Tragen von Oberkörperkompressionsbekleidung eine Verbesserung der Leistungsfähigkeit zu erzielen ist. Für die Studie wurden 23 Elite-Athleten des Deutschen Kanuverbands (6 Frauen, 17 Männer) rekrutiert. Diese absolvierten auf einem Regattasee eine 1650 m lange Teststrecke mit gewohnten Wettkampf- bzw. Trainingsbooten und -paddeln. Die Athleten wurden randomisiert in 2 Gruppen eingeteilt und durchliefen die Teststrecke mit und ohne Oberkörperkompressionsbekleidung. Neben Zwischen- und Endzeiten wurden kapilläre Blutlaktatkonzentrationen erhoben. Für die Statistik wurden ein effektbasierter Ansatz („Magnitude-Based Inferences“) und eine zusätzliche Einzelfallanalyse durchgeführt. Hierfür wurde der mittlere bzw. individuelle Effekt in Relation zur kleinsten lohnenswerten Differenz betrachtet. Die effektbasierte Statistik zeigt im Mittel, dass durch das Tragen von Oberkörperkompressionsbekleidung keine eindeutigen Veränderungen hinsichtlich der Leistungsfähigkeit zu erzielen sind. Die Änderungen der Laktatkonzentrationen sind hingegen eindeutig, aber als trivial anzusehen. Im Gegensatz zum mittelwertanalytischen Vorgehen zeigen die Ergebnisse der Einzelfallanalyse, dass es bei 13,0 % der Athleten zu einer Leistungsverbesserung und bei 4,4 % zu einer geringeren Laktatkonzentration durch das Tragen von Oberkörperkompressionsbekleidung kam. Bei 4,4 % der Athleten kam es zu einer Leistungsverschlechterung und bei 17,4 % zu einer höheren Laktatkonzentration. Unsere Studie zeigt, dass das Tragen von Oberkörperkompressionsbekleidung bei hochtrainierten Elite-Kanusportlern im Mittel keinen Einfluss auf die Leistungsfähigkeit und Laktatkonzentration hat. Im Einzelfall zeigen sich jedoch positive und negative Effekte, die für den Elitebereich praktisch bedeutsam sein können.
BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle
Authors: Delezie Julien , Weihrauch Martin , Maier Geraldine , Tejero Rocío , Ham Daniel J. , Gill Jonathan F. , Karrer-Cardel Bettina , Rüegg Markus A. , Tabares Lucía , Handschin Christoph 
Published: July 2019

Significance
The brain-derived neurotrophic factor (BDNF) is essential to promote neuronal differentiation, plasticity, and survival. Altered BDNF expression is associated with several pathologies, including neuropsychiatric and neurodegenerative disorders, cardiovascular diseases, diabetes, and motor neuron diseases. Although BDNF has been identified as a contraction-induced myokine, its involvement in muscle physiology is unclear. Using functional, cellular, and molecular approaches, we report here that the myokine BDNF regulates glycolytic muscle fiber-type identity. Our findings warrant additional studies to determine whether modulating the activity of BDNF represents an effective therapeutic strategy to delay or even prevent muscle wasting disorders in which the function of glycolytic muscle fibers is compromised (e.g., in Duchenne muscular dystrophy, muscle insulin resistance).
Plasmacytoid dendritic cell dysfunction caused by heat stress is improved by administration of Lactococcus lactis strain plasma in mice
Authors: Sugimura Tetsu , Jounai Kenta , Ohshio Konomi , Fujiwara Daisuke 
Published: July 2019

ABSTRACT
Plasmacytoid dendritic cells (pDCs) are crucial in anti-viral immunity, acting as regulators in both adaptive and innate immunity. In this study, brief heat stress caused a decrease in splenic pDC activity in mice. Administration of Lactococcus lactis strain Plasma (LC-Plasma) significantly suppressed the decrease in pDC activity and IFN-α production.
Abbreviations: LC-Plasma: Lactococcus lactis strain Plasma; LAB: lactic acid bacteria; pDC: plasmacytoid dendritic cell; IFN: interferons; mDC: myeloid dendritic cells
A Fourier method for estimating potential energy and lateral forces from frequency-modulation lateral force microscopy data
Authors: Seeholzer T , Gretz O , Giessibl F J , Weymouth A J 
Published: July 2019

Abstract
One mode of atomic force microscopy (AFM) is frequency-modulation AFM, in which the tip is driven to oscillate at its resonance frequency which changes as the tip interacts with the surface. Frequency-modulation lateral force microscopy (FM-LFM) is the variant of this technique in which the tip is oscillated along the surface. For an isolated adsorbate on a flat surface, the only signal in FM-LFM is caused by the short-range interaction with the adsorbate. Various deconvolution methods exist to convert the observed frequency shift into the more physically relevant parameters of force and energy. While these methods are often used for FM-AFM data, the high number of inflection points of FM-LFM data make standard deconvolution methods less reliable. In this article, we present a method based on Fourier decomposition of FM-LFM data and apply it to data taken of an isolated CO molecule on the Pt(111) surface. We probe the potential energy landscape past the potential energy minimum and show how over an adsorbate, the potential energy can be evaluated with a single FM-LFM image.
The ambiguity function and the displacement operator basis in quantum mechanics
Authors: Ben-Benjamin J S , Unruh W G 
Published: July 2019

Abstract
We present a method for calculating expectation values of operators in terms of a corresponding c-function formalism which is not the Wigner–Weyl position-momentum phase-space, but another space. Here, the quantity representing the quantum system is the expectation value of the displacement operator, parametrized by the position and momentum displacements, and expectation values are evaluated as classical integrals over these parameters. The displacement operator is found to offer a complete orthogonal basis for operators, and some of its other properties are investigated. Connection to the Wigner distribution and Weyl procedure are discussed and examples are given.
Forward-headed structure change of acetic acid–water binary system by stimulated Raman scattering*
Authors: Liu Zhe , Yang Bo , Zhao Hong-Liang , Li Zhan-Long , Men Zhi-Wei , Wang Xiao-Feng , Wang Ning , Cao Xian-Wen , Wang Sheng-Han , Sun Cheng-Lin 
Published: July 2019

Abstract
The acetic acid–water binary system is a classical hydroxy–carboxy mixed system, while new and interesting phenomena appear under stimulated Raman scattering (SRS). Compared with the weaker signal of the acetic acid–water binary system obtained in spontaneous Raman scattering, SRS provides a finer band and a relatively distinct structural transition point. The structural transformation points are respectively at 30% and 80% by volume ratio under the condition of spontaneous Raman spectroscopy, while they are respectively at 15% and 25% under the condition of SRS. This phenomenon is attributed to the generation of laser induced plasma and shockwave induced dynamic high pressure environment during SRS.