bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel insights into Sabino1 and splashed white coat color patterns in horses
Authors: Druml T. , Grilz‐Seger G. , Neuditschko M. , Horna M. , Ricard A. , Pausch H. , Brem G. 
Published: April 2018

SummaryWithin the framework of genome‐wide analyses using the novel Axiom® genotyping array, we investigated the distribution of two previously described coat color patterns, namely sabino1 (SBI), associated with the KIT gene (KI16+1037A), and splashed white, associated with the PAX3 gene (ECA6:g.11429753C>T; PAX3C70Y), including a total of 899 horses originating from eight different breeds (Achal Theke, Purebred Arabian, Partbred Arabian, Anglo‐Arabian, Shagya Arabian, Haflinger, Lipizzan and Noriker). Based on the data we collected we were able to demonstrate that, besides Quarter horses, the PAX3C70Y allele is also present in Noriker (seven out of 189) and Lipizzan (three out of 329) horses. The SB1 allele was present in three breeds (Haflinger, 14 out of 98; Noriker, four out of 189; Lipizzan one out of 329). Furthermore, we examined the phenotypes of SB1‐ and PAX3C70Y‐carrier horses for their characteristic white spotting patterns. None of the SB1/sb1‐carrier horses met the criteria defining the Sabino1 pattern according to current applied protocols. From 10 heterozygous PAX3C70Y‐carrier horses, two had nearly a splashed white phenotype. The results of this large‐scale experiment on the genetic association of white spotting patterns in horses underline the influence of gene interactions and population differences on complex traits such as Sabino1 and splashed white.
Placing Angola: Racialisation, Anthropocentrism, and Settler Colonialism at the Louisiana State Penitentiary's Angola Rodeo
Authors: Gillespie Kathryn 
Published: April 2018

AbstractThe Louisiana State Penitentiary (Angola) is a site embedded with historical legacies of plantation slavery and settler colonialism; as the largest maximum security penitentiary in the United States, the prison also reflects the racial injustice of contemporary US mass incarceration. Situated on the site of an old plantation, the prison hosts the Angola Rodeo twice a year, an event that crystallises violent multispecies social relations in the merging of the US West and South as two distinct kinds of colonial projects. Whereas much scholarship and activism has worked against the wholesale dehumanisation inherent in chattel slavery, settler colonialism, and mass incarceration, this paper works to interrogate and disrupt the human–animal binary through which processes of dehumanisation are sustained. Drawing together postcolonial studies and animal studies, the paper centres empirical research on the Angola Rodeo to highlight how racialisation and anthropocentrism are intertwined logics of subordination and exclusion that carry forward into the present. Ultimately, the paper suggests the need for a mode of analysis and action that does not maintain the subordination of the animal, and instead, takes a de‐anthropocentric and decolonial approach to injustice.
Naturalising Finance, Financialising Natives: Indigeneity, Race, and “Responsible” Agricultural Investment in Canada
Authors: Sommerville Melanie 
Published: April 2018

AbstractThis article examines the racialised political ecologies inscribed by financial investments in a large‐scale corporate farm engaging Indigenous peoples in the Canadian prairies. Established in 2009, One Earth Farms (OEF) became one of Canada's largest farms by leasing First Nations’ farmland. I argue thatOEF's early success hinged on its promise of “naturalising finance” by engaging agriculture as a purportedly more real and stable financial vehicle relative to traditional assets. Simultaneously,OEFclaimed to facilitate First Nations’ participation in agriculture by integrating their land and labour with financial flows—effectively “financialising natives”. I document the specific opportunities for capital accumulation and valuation mobilised by the project's claims to be providing reparative historical redress to First Nations through investor and corporate ecological and social “responsibility”. Reflecting on colonisation and racialisation processes, I demonstrate the ways that Indigenous histories and subjectivities are mobilised and monetised in contemporary political ecological projects.
Persistent socket pain postenucleation and post evisceration: a systematic review
Authors: Hogeboom Charlotte S. E. , Mourits Daphne L. , Ket Johannes C. F. , Tan H. Stevie , Hartong Dyonne T. , Moll Annette C. 
Published: April 2018

AbstractPurposeTo investigate causes, diagnostics and treatment modalities for persistent socket pain (PSP) after enucleation and evisceration.MethodsA systematic search was undertaken in accordance with the PRISMA Statement, in PubMed, Embase.com and Thomson Reuters/Web of Science. We searched for relevant papers until the 28th of July 2016. Inclusion criteria were (1) patients with a history of enucleation or evisceration, (2) PSP, (3) report of the cause and/or used diagnostics and/or treatment modality, (4) full text in English, Dutch or Spanish language. Excluded were (1) review articles, (2) comments, and publications concerning, (3) nonhumans, (4) exenterated patients, (5) acute postoperative pain, or (6) periorbital pain without pain in the socket. Given the lack of high quality evidence from randomized controlled trials, we examined all available evidence from primary observational studies and assessed quality within this lower level of evidence.ResultsA total of 32 studies were included. Causes of PSP found were prosthesis‐related (n = 5), dry socket (n = 2), trochleitis (n = 3), compression of the trigeminal nerve (n = 2), implant‐related (n = unknown), inflammation (n = 5), surgery‐related (n = 4), neuromas (n = 8), malignant tumours (n = 3), psychiatric/psychosocial (n = 2), phantom pain (n = 149), rarer entities (n = 3) or unknown (n = 14). Nonsurgical treatments suffice for conditions as trochleitis, prosthesis‐related pain, dry socket and for phantom pain. Other causes of pain may require more invasive treatments such as implant removal.ConclusionCareful history and examination can give some direction in the diagnostic procedure; however, PSP is probably multifactorial and the specific origin(s) may remain uncertain. Implant replacement can be an effective treatment. Studies to identifiy less invasive procedures are required.
Temporal distribution of 5BrdU‐labelled cells suggests that most injured tissues contribute proliferating cells for the regeneration of the tail and limb in lizard
Authors: Alibardi Lorenzo 
Published: April 2018

AbstractAfter tail and limb amputation in lizard, injection of 5BrdU for 6 days produces immunolabelled cells in most tissues of tail and limb stumps. After further 8 and 16 days, and 14 and 22 days of regeneration, numerous 5BrdU‐labelled cells are detected in regenerating tail and limb, derived from most stump tissues. In tail blastema cone at 14 days, sparse‐labelled cells remain in proximal dermis, muscles, cartilaginous tube and external layers of wound epidermis but are numerous in the blastema. In apical regions at 22 days of regeneration, labelled mesenchymal cells are sparse, while the apical wound epidermis contains numerous labelled cells in suprabasal and external layers, indicating cell accumulation from more proximal epidermis. Cell proliferation dilutes the label, and keratinocytes take 8 days to migrate into corneous layers. In healing limbs, labelled cells remain sparse from 14 to 22 days of regeneration in wound epidermis and repairing tissues and little labelling dilution occurs indicating low cell proliferation for local tissue repair but not distal growth. Labelled cells are present in epidermis, intermuscle and peri‐nerve connectives, bone periosteum, cartilaginous callus and sparse fibroblasts, leading to the formation of a scarring outgrowth. Resident stem cells and dedifferentiation occur when stump tissues are damaged.
A randomised, placebo‐controlled, multicentre, Phase 2 clinical trial to evaluate the efficacy and safety of GV1001 in patients with benign prostatic hyperplasia
Authors: Moon Kyong Tae , Yoo Tag Keun , Kwon Se Yun , Ha Ji Yong , Byun Seok Soo , Kim Jang Hwan , Chung Jae Il , Kim Tae Hyoung , Moon Hong Sang , Kim Sang Jae , Lee Kyung Seop 
Published: April 2018

ObjectivesTo evaluate the efficacy and safety of three dosing schemes of GV1001 in patients with benign prostatic hyperplasia (BPH).Patients and methodsEligible patients were men aged ≥50 years, with an International Prostate Symptom Score (IPSS) of ≥13, maximum urinary flow rate (Qmax) of 5–15 mL/s, post‐void residual urine volume (PVR) of ≤200 mL, and prostate volume of ≥30 mL. After a 4 week run‐in period, patients were randomly assigned to one of three treatment schedules: Group 1, GV1001 0.4 mg, 2‐week interval; Group 2, GV1001 0.56 mg, 2‐week interval; Group 3, GV1001 0.56 mg, 4‐week interval) or placebo (Group 4). The eligible patients were administered GV1001 or placebo, for a total of seven intradermal injections that were administered at 2‐week intervals at weeks 0, 2, 4, 6, 8, 10, and 12. Treatment continued for 12 weeks, and efficacy was evaluated at weeks 4, 8, 12, 13, and 16. Safety was evaluated throughout the 16‐week period. The primary efficacy variable was change from baseline (CFB) in total IPSS. Secondary endpoints were CFB in Qmax, PVR, prostate volume, International Index of Erectile Function score, plasma testosterone level, dihydrotestosterone level, and prostate‐specific antigen level.ResultsA total of 161 patients were included (Group 1, n = 41; Groups 2–4, n = 40). Most patients (88.8%) received all planned doses of the study treatment. At week 13, a statistically significant difference in the mean CFB in IPSS was seen in GV1001 treatment Groups 1 and 2 vs the control group for the full analysis population (−3.5 [control] vs −7.2 and −6.8 in Groups 1 and 2, respectively; both P < 0.05). There were also statistically significant differences in CFB at weeks 8, 12, 13, and 16 in treatment Groups 1 and 2 vs control in the per‐protocol population. There was a statistically significant reduction in prostate gland volume at week 16 vs control in all treatment groups (0.8 [control] vs −4.6, −2.5, and −4.2 mL in Groups 1–3, respectively; all P < 0.05). There were no statistically significant differences found in other secondary outcome measures. Adverse event (AE) reporting was similar across all four groups. No treatment‐emergent AEs were considered to be related to the study drug.ConclusionsThe results indicate that GV1001 was effective and well tolerated, and may provide potential beneficial effects in patients with BPH. Compared with medical therapies that require daily dosing, the convenient dosing regimen of GV1001 may provide greater patient adherence. Further investigation of these observations will require large‐scale clinical evaluation.
Intermittent vs continuous docetaxel therapy in patients with metastatic castration‐resistant prostate cancer – a phase III study (PRINCE)
Authors: Cash Hannes , Steiner Ursula , Heidenreich Axel , Klotz Theodor , Albers Peter , Melchior Sebastian , Martus Peter , Fuller Florian , Magheli Ahmed , Hinz Stefan , Kempkensteffen Carsten , Miller Kurt ,   the PRINCE investigators
Published: April 2018

ObjectiveTo investigate non‐inferiority of intermittent docetaxel compared to continuous docetaxel in patients with metastatic castration‐resistant prostate cancer (mCRPC).Patient and MethodsThe investigator initiated randomised phase III study included 187 chemotherapy‐naïve patients with mCRPC who were allocated to two treatment arms: intermittent docetaxel and continuous docetaxel. Docetaxel was applied in both arms as weekly (35 mg/m2) or 3‐weekly (75 mg/m2). The primary endpoint was 1‐year survival, which was tested for non‐inferiority (margin δ = 0.125). The secondary endpoints were: overall survival (OS), progression‐free survival (PFS), median time to treatment failure (TTF), and toxicity.ResultsOf 156 eligible patients, 78 were allocated to each arm. The intermittent treatment met the non‐inferiority criteria for 1‐year survival (two‐sided 95% confidence interval, −0.12, 18, P = 0.022), but not for OS, according to the result of a post hoc analysis. The differences between the study arms in PFS and TTF were not significant. The median (range) treatment holiday in the intermittent arm was 110 (13–486) days, or 38% of the overall treatment duration. Safety profiles of both study arms were comparable. The main limitation of this study was that the planned number of patients could not be recruited.ConclusionIntermittent docetaxel chemotherapy was non‐inferior to continuous therapy for 1‐year survival; non‐inferiority in regard to OS was not reached.
Welfare analysis when people are different
Authors: Pendakur Krishna 
Published: April 2018

AbstractInequality and poverty estimation (indeed, all welfare analysis) must deal with the fact that people are heterogeneous. Equivalence scales and indifference scales are tools that may be used for this. An equivalence scale gives the relative costs faced by different people; an indifference scale gives the relative cost of living for people in different types of households. Equivalence scales and indifference scales can be estimated using off‐the‐shelf household‐level consumer expenditure data and standard econometric techniques for nonlinear equation systems. I offer a short introduction to the identification, estimation and use of equivalence scales and indifference scales and argue that these are complementary tools in the analysis of inequality and poverty. The methods are illustrated with Canadian household expenditure data from the Surveys of Household Spending 2004–2009. Estimated equivalence scales for disability are presented, along with estimated household model parameters and an analysis of consumption poverty.RésuméAnalyse du niveau de bien‐être quand les gens sont différents.Les mesures d’inégalité et de pauvreté (en fait toutes les mesures et analyses du niveau de bien‐être) doivent prendre en compte le fait que les gens sont hétérogènes. Les échelles d’équivalence et les échelles d’indifférence sont des outils qu’on peut utiliser pour ce faire. Une échelle d’équivalence établit les coûts relatifs auxquels les différentes personnes doivent faire face; une échelle d’indifférence établit le coût relatif différent de gens qui font partie de différents types de ménages. Les échelles d’équivalence et les échelles d’indifférence peuvent être estimées à l’aide de données sur les dépenses de consommation des ménages pour les produits et services disponibles sur le marché, et des techniques économétriques conventionnelles pour calibrer les systèmes d’équations non‐linéaires. L’auteur présente une courte introduction aux problèmes d’identification, d’estimation, et d’usage des échelles d’équivalence et des échelles d’indifférence, et propose que ce sont des outils complémentaires dans l’analyse de l’inégalité et de la pauvreté. Les méthodes sont illustrées à l’aide de données sur les dépenses des ménages canadiens fournies par les Enquêtes sur les dépenses des ménages 2004‐2009. Les échelles d’équivalence sont estimées pour l’incapacité, ainsi que les paramètres estimés du modèle des ménages et une analyse de la pauvreté en termes de consommation.
Relationship to parents in adulthood with a background of out‐of‐home care in childhood
Authors: Andersson Gunvor 
Published: April 2018

AbstractThe longitudinal study started with children aged up to 4 who had been taken into care because of unacceptable living conditions and deficient parental care. After their initial stay in a children's home, the 26 children in the research group went on to have diverse placement histories throughout their childhood (up to age 18). The children have been divided into 4 subgroups in accordance with the length of time they lived with 1 of their parents or with foster parents. Relationships were 1 of the themes in the primary study as well as in all 8 rounds of follow‐up. This article is based on the 2 most recent rounds when the children had reached the ages of 25 to 30 and 35 to 39. A few of the interviewees talked about a close relationship to 1 of their parents, some had occasional contact, and many more had no contact at all, felt abandoned, or had decided to keep their parent(s) at a distance, not least out of consideration for their own children. The interviews showed that their adult relationship to and/or feelings for parents were still problematic and negatively affected their own well‐being, even if their parent(s) had died.
Allergic contact dermatitis caused by isobornyl acrylate in OmniPod, an innovative tubeless insulin pump
Authors: Raison‐Peyron Nadia , Mowitz Martin , Bonardel Nathalie , Aerts Olivier , Bruze Magnus 
Published: April 2018

BackgroundThe frequency of allergic contact dermatitis caused by (meth)acrylates is increasing worldwide, and isobornyl acrylate (IBOA) has been identified as a culprit sensitizer in FreeStyle Libre, a medical device used by diabetic patients.ObjectivesTo report on 4 patients sensitized to IBOA contained in OmniPod, a new, tubeless insulin pump, and to describe the clinical and chemical analytical work‐up.MethodFour patients with eczematous skin eruptions after using OmniPod, including 2 with previous adverse skin reactions to FreeStyle Libre, were patch tested with a baseline series and additional (meth)acrylates, including IBOA in several concentrations and/or vehicles. Gas chromatography‐mass spectrometry (GC‐MS) was used to identify the presence of IBOA in OmniPod.ResultsAll patients were shown to be sensitized to IBOA. GC‐MS identified IBOA in OmniPod, with the highest concentrations being found in the unit itself and not in the adhesive patch.ConclusionsThe OmniPod tubeless insulin pump is another source of IBOA, and its use may lead to primary sensitization to this acrylate, or may provoke elicitation of allergic contact dermatitis in previously sensitized patients. Our cases highlight the need to obtain satisfactory cooperation from pharmaceutical companies involved in the manufacture of these widely used medical devices.
Use of drug intoxicated donors for lung transplant: Impact on survival outcomes
Authors: Whited William M. , Ising Mickey S. , Trivedi Jaimin R. , Fox Matthew P. , van Berkel Victor 
Published: April 2018

AbstractIntroductionThe number of increasing deaths due to the opioid epidemic has led to a potential greater supply of organ donors. There is hesitancy to use drug intoxicated donors, and we evaluated their impact on post‐transplant survival.BackgroundPatients ≥18 years of age undergoing lung transplantation and donors from whom at least one organ was donated between January 2005 and March 2015 were selected from the United Network of Organ Sharing database. Baseline characteristics and post‐transplant survival were compared between drug intoxicated and all other donors.ResultsThe utilization of drug intoxicated donors increased from 1.86% in 2005 to 6.23% in 2014. The 2 study groups had similar characteristics including age, gender, and Lung Allocation Score. As compared to all other donors, drug intoxicated donors were younger (29.1 ± 9.4 vs 34.6 ± 13.4 years, P < .0001), less likely to be male (52% vs 61%, P < .0001), and had a greater smoking history (14% vs 11%, P .04). There was no difference in post–lung transplant survival at 1, 3, and 5 years between drug intoxicated donors (85%, 64%, and 47%) and non‐drug intoxicated donors (83%, 65%, and 51%).ConclusionTransplantation utilizing drug intoxicated donor lungs has significantly increased over the past decade without significantly impacting post‐transplant survival.
Diagnosis of anaplastic large cell lymphoma on late peri‐implant breast seroma: Management of cytological sample by an integrated approach
Authors: Ronchi A. , Montella M. , Argenzio V. , Lucia A. , De Renzo A. , Alfano R. , Franco R. , Cozzolino I. 
Published: April 2018

IntroductionPeri‐implant breast seroma is a late clinical presentation of reconstructive surgery or augmentation mammoplasty with breast implants. Pre‐operative cytological evaluation of the peri‐implant breast seroma is a common clinical approach, showing mainly an inflammatory reaction or more rarely a breast implant‐associated anaplastic large cell lymphoma. Herein, we reported the role of cytology in the evaluation of peri‐implant breast seroma and its critical pre‐operative implications.MethodsEight cases of peri‐implant breast seroma from files at Luigi Vanvitelli University were identified between January and December 2017. In all cases, seroma was aspirated; cytospins were performed and stained by Papanicolaou stain; finally, in all cases, a cell block was obtained for immunocytochemical evaluation and, in one case, for FISH to detect ALK1‐gene translocation.ResultsThe median age of patients was 48 years and the mean time between the implant placement and the occurrence of peri‐implant breast seroma was 18 months. Microscopic examination showed breast implant‐associated anaplastic large cell lymphoma in one case, aspecific inflammatory reaction in six cases and silicon‐associated reaction in one case.ConclusionsPeri‐implant breast seroma may be caused by several pathological conditions with different clinical behaviour. A proper cytological approach to peri‐implant breast seroma allows a correct differential diagnosis between inflammatory conditions and breast implant‐associated anaplastic large cell lymphoma and an appropriate management of the patient.
Fishing pressure and species traits affect stream fish invasions both directly and indirectly
Authors: Peoples Brandon K. , Midway Stephen R. 
Published: April 2018

AbstractAimWe sought to identify direct and indirect effects of factors contributing to establishment and spread of 272 stream fish species.LocationTwo hundred and ninety‐seven watersheds in the eastern United States.MethodsWe modelled two variables: (1) whether a species had become established outside its native range (establishment) and (2) the number of watersheds in which species established outside their native range (spread). We estimated these variables by comparing historical distributions to a rich data set of contemporary sampling. We calculated metrics of human use (indexing propagule pressure), and gathered species trait data from an open‐access database. We then used piecewise path analysis to estimate direct and indirect effects of human use, native range size and species traits on the two metrics of species introductions.ResultsWe identified a hierarchical causal structure in which native range size and fishing pressure were important direct determinants of introductions. Species traits had some direct effects, but played a more indirect role. Native range size was significantly affected by thermal tolerance and diet breadth. Likewise, fishing pressure was significantly affected by life history strategy: larger‐bodied, longer‐living and more fecund species were positively associated with fishing pressure.Main conclusionsFunctional traits can confer an advantage to some species during the establishment phase, but human use is important for subsequent dispersal throughout the non‐native range. However, human use is non‐random, and is largely a function of species traits. Considering both direct and indirect effects of traits across stages of the invasion process can help to elucidate the full role of traits in species invasions.