bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence of use: A selective COX-2 inhibitor in the treatment of experimental chronic pancreatitis induced by Dibutyltin dichloride
Authors: Sukhodolya Sergij , Falalyeyeva Tetyana , Kuryk Olena , Petrushenko Victoriya , Beregova Tetyana 
Published: March 2018

Abstract
The search for new prophylactic and therapeutic drugs for the treatment of chronic pancreatitis (CP) is an urgent problem in current pancreatology. A promising direction in CP therapy may be the use of nonsteroidal anti-inflammatory drugs. Hence, the aim of the present study was to investigate the selective inhibition properties of COX-2 rofecoxib on the development of pancreas fibrosis in rats with experimental chronic pancreatitis induced by Dibutyltin dichloride (DBTC). The 60 male albino Wistar rats of our study were placed into three groups of 20 animals in each: I - the intact control; II - that which received an intraperitoneal injection (i.p.) of DBTC (6 mg/g); III - those which, 28 days after administration of DBTC (6 mg/g, i.p.), received a two-week course of treatment of rofecoxib (5 mg/kg, i.p). One day after rofecoxib treatment was completed, analysis was undertaken regarding the level of amylase, as well as the pancreatic amylase and lipase in the blood serum and the prostaglandin E2 in the pancreatic tissue. In addition, the morphological condition of the pancreas was ascertained. The obtained data suggest that administration of Rofecoxib reduces the development of fibrosis and improves the morpho-functional state of the pancreas in rats with chronic pancreatitis induced by DBTC. Thus, treatment with a selective COX-2 inhibitor could be a possible strategy for improving the clinical outcome of patients with CP.
Effect of standard and reversible arrangements of Ph.Eur./USP extraction cells during dissolution tests of calcium dobesilate in hydrogel formulation
Authors: Lisik Anna , Wojcik-Pastuszka Dorota , Twarda Maria , Berkowski Ryszard , Musial Witold 
Published: March 2018

Abstract
The aim of the study was to evaluate, in comparison to the reference product, the effect of the hydrophilic nonionic polymers: methylcellulose (MC) and hydroxypropyl methylcellulose (HPMC), as well as the anionic polymers - copolymers of acrylic acid, on the release kinetics of a calcium dobesilate hydrogel formulation intended for application on the skin. In this work, we used an ointment cell for the release of the active pharmaceutical ingredient (API) from the formulations. This release was performed by employing the paddle method at 100 rpm, with the extraction cells placed in the release vessels in two different positions: with the semipermeable membrane faced to the top, or to the bottom of the vessel. Released API percentage was assessed via the validated spectrophotometric method. In the study with standard placement of the ointment cell, the release rates ranged from 4.45×10-3 min-1 for a formulation containing polyacrylic acid (PA), to 6.96 × 10-3 min-1 for a formulation based on HPMC. In the group of nonionic polymers, the release rate is higher in the case of HPMC, and lower in the case of MC. In the group of anionic polymers, the release rate is higher with the formulation of a modified copolymer of acrylic acid 11 (PC11), while release from a formulation comprising a polymer PA is rather prolonged. We found that the placement of the extraction cell does not affect the alignment of the formulations investigated in terms of the release rates in the group of non-ionic formulations: HPMC > MC, and in the group of preparation of ionic polymers: PC11 > PA.
The occurrence of Entamoeba gingivalis among patients with periodontal disease
Authors: Luszczak Joanna , Bartosik Michal , Rzymowska Jolanta , Sochaczewska-Dolecka Agnieszka , Tomaszek Ewa , Wysokinska-Miszczuk Joanna , Bogucka-Kocka Anna 
Published: March 2018

Abstract
According to some studies, the Entamoeba gingivalis colonizing the gingival tissue is an important agent in bringing about periodontitis. Other studies, however, deem it an opportunist that is able to survive in the medium induced by periodontal disease. The aim of this study was to investigate the prevalence of Entamoeba gingivalis infection in patients from the Department of Periodontology, and compare this population with that of healthy people, so as to analyze the relationships between infection and patient sex and age. The result of this work is that in both groups, a correlation (p = 0,19) has been noted between the occurrence of amoebae and other diseases in the oral cavity. Indeed, 81,4% of all patients with some periodontal disease showed the presence of amoeba. Among those who are not afflicted with oral diseases, the presence of amoeba was indicated in 62,5% of the total. In addition, a correlation between the person's age and the presence of protozoa (p = 0,15) was strongly marked among women (p = 0,19). In the three age groups of women in this study (40-49, 60-69, and above 80 years), we observed a 100% presence of protozoa.
Our study leads us to the conclusion that infections with Entamoeba gingivalis should be regarded as an factor that is associated with the pathological changes occurring in patients with periodontal diseases.
The evaluation of 25(OH)D concentration in blood serum of chronic heart failure patients
Authors: Lewandowski Tomasz , Baginski Andrzej , Malecha-Jedraszek Arleta , Mosiewicz Jerzy , Donica Helena 
Published: March 2018

Abstract
This current study examined patients with severe chronic heart failure (CHF) in order to ascertain the held vitamin D, based on an assessment of calcidiol [25(OH)D] concentration. It also identified and evaluated possible correlations between 25(OH)D level and the concentration of total calcium, inorganic phosphates and creatinine concentration in their serum. Herein, venous blood samples were taken from 36 patients with CHF. Diagnosis was confirmed by echocardiographic, as well as by electrocardiographic examinations. In this work, the control group consisted of 41 randomly selected healthy individuals. The results of our study showed that CHF patients had significantly lower concentration of 25(OH)D, as well as total calcium and inorganic phosphates. Moreover, mean creatinine concentration was higher, in comparison to the control group, but did not exhibit statistical significance. As calcium-phosphate homeostasis is regulated by numerous factors, including PTH, neurohormonal factors and calcitriol (1,25(OH)2D), it is possible that vitamin D deficiency may play a significant role in the pathomechanism of CHF, and a lowered 25(OH)D level may be related to progression of the disease.
Evaluation of the surface structure of composite restorations in light of own pilot research
Authors: Chalas Renata , Orlowski Miroslaw , Tarczydlo Bozena , Zubrzycka-Wrobel Joanna , Maj Karol , Wojcik-Checinska Ilona 
Published: March 2018

Abstract
Research on the dental restorative materials employed in remedying dental cavities has been conducted on many levels and areas, both with application of clinical and laboratory methods. One of the elements that determines whether the restoration may be degraded is the condition of its surface. The aim of the study was to assess the texture surface of composite restorations using a non-contact method of teeth models scanning. In this work, ten medium size cavities on the occlusal surfaces of molars in adult patients were prepared and restored with resin composite. Before undertaking the procedure and after the finishing and polishing of the restorations, impressions were taken and sent into the laboratory so as to prepare plaster casts. Every cast was then scanned utilizing the non-contact 3D surface measurement instrument so as to assess the texture surface of the restoration. The resulting three dimensional analyses of post-restoration models showed the correct marginal adaptation of resin composite dental material to the hard tooth structures and its smooth filling occlusal surface. Additional comparison of scans done before and after restoring the cavities allowed the calculating of differences in volume, mean and maximum heights. The applied method of analysis is thought to be helpful in the detailed evaluation of restoration dental material texture. Moreover, the enabled possibility of continuous observation is expedient for assessing the usefulness of the method in standard dental practice.
Influence of different excipients on the properties of hard gelatin capsules with metamizole sodium
Authors: Rogowska Magdalena , Iwaniak Karol , Polski Andrzej , Slawinska Karolina , Sobotka-Polska Karolina , Modrzewska Joanna , Poleszak Ewa 
Published: March 2018

Abstract
Metamizole is an effective non-opioid analgesic drug used in the treatment of acute and chronic pain. Due to induced potentially life-threatening blood disorders, metamizole was withdrawn from market in many parts of the world, however, it is one of the most popular analgesics in Poland that is available as an over the counter drug. Patients tend to prefer capsules over tablets, as they are easier to swallow and taste better. The powder-filled capsules also have greater bioavailability and require less excipients, as compared to tablets. Polymic excipients are mainly used in capsule filling, and have influence upon the physico-chemical properties of the hard gelatin capsules and the powder formulation. The aim of the study was to determine whether various combinations of polymers impact the disintegration time and pharmaceutical availability of hard gelatin capsules with metamizole sodium. The results of our work demonstrated that the 80% of all active substance was released in all tested formulations within 15 minutes. Herein, the capsule containing lactose monohydrate had the longest release (4% after 2 min.), while capsules containing mannitol had the fastest release (81.2% after 2 min.). Moreover, the addition of HPMC to capsules with lactose brought about a slight increase in the metamizole release rate, while the addition of PVP 30 to capsules with microcrystalline cellulose slightly accelerated release. This data suggests that the use of different polymers in capsules formulation brings about changes in the physical properties of powders and modifies the release profile of metamizole. In our study, the most preferred formulation was one containing microcrystalline cellulose (good powder properties and fairly fast release).
Selected issues concerning oral health in female patients with eating disorders: a survey study
Authors: Mazurek Mateusz , Szyszkowska Anna , Mazurek Agata , Szymanska Jolanta 
Published: March 2018

Abstract
The study aimed to evaluate behaviours relevant to oral health and the condition of the teeth and gums in women with eating disorders. A survey study covered a group of 30 patients aged 14-36 years suffering from diagnosed eating disorders and treated in closed psychiatric wards. The control group included 30 healthy women at the mean age corresponding to that of the patient group. The questions concerning oral health-relevant behaviours referred to the frequency of tooth brushing and the kind of toothbrush used, the frequency of dental visits, fear of dental visits, and self-evaluation of the selected items of oral health status. The survey results were analysed statistically. Behaviours relevant to oral health in women with eating disorders include increased oral hygiene and the attitude to dental visits that does not diverge from the customary one. The patients found the presence of enamel damage to be as frequent as in the healthy subjects. Eating disorders are, however, conducive to more frequent gum disorders and the feeling of dryness in the mouth.
Pericardial tamponade as the first manifestation of bronchial adenocarcinoma
Authors: Dorota Kuzemko , Dariusz Baranowski , Andrzej Prystupa , Ewa Fidor-Mikita , Patrycja Lachowska-Kotowska , Grzegorz Dzida 
Published: March 2018

Abstract
Case report. A 58-year-old woman was admitted to the Department of Internal Diseases due to resting dyspnoea, tachycardia and malaise. Her chest X-ray revealed inflammatory lesions, and empiric antibiotic therapy was initiated. Chest CT was then performed which showed lung tumours. During hospitalization, the patient suddenly developed cardiogenic shock induced by pericardial tamponade. The fluid from pericardium was subsequently collected. An histopathological examination of the fluid showed the presence of atypical cells. The patient then underwent bronchoscopy, the biopsy material of which revealed bronchial adenocarcinoma.
Bone metabolism and RANKL/RANK/OPG trail in periodontal disease
Authors: Czupkallo Lukasz , Rahnama Mansur , Kielbowicz Dominik , Lobacz Michal , Kozicka-Czupkallo Maryla 
Published: March 2018

Abstract
Periodontal disease is an inflammatory disease of multifactorial etiology. In order for it to appear there must come to an imbalance between the effects of pathogens and host defense mechanisms. As a result of its course the destruction of structures supporting the teeth appears (periodontium, cement, bone), and consequently leads to teeth loosening and loss. In recent years, the participation of RANKL/RANK/OPG in bone remodeling process was highligted.
At the molecular level the bone resorption is regulated through the interaction of the ligand receptor activator of nuclear NF-kappa B (RANKL) and osteoprotegerin (OPG), which is a system of two proteins belonging to the protein tumor necrosis factor (TNF). Recent findings about the RANKL protein and OPG have shed new light on the previously unexplained phenomenon of the basis of bone resorption.
Research has shown that both protein OPG and RANKL can be detected in gingival crevicular fluid, which has become a window of opportunity in the analysis of non-invasive markers of periodontal tissues, confirming elevated levels of RANKL protein in periodontal disease, and decreased levels of OPG protein. Bone resorption is initiated by the binding of the RANKL protein to receptors RANK present on the surface of mature osteoclasts, and their precursors, which leads to the differentiation and activation of osteoclasts. OPG, being RANKL’s inhibitor, has, in turn, opposite characteristics to RANKL, resulting in the reduction of osteoclastogenesis process. Despite all this, the exact mechanism of bone resorption has not yet been elucidated.
The influence of renin angiotensin aldosterone system blockers on asymmetric dimethylarginine levels in patients with chronic glomerulonephritis
Authors: Heleniak Zbigniew , Zdrojewski Zbigniew , Wisniewski Piotr , Bieniaszewski Leszek , Rutkowski Boleslaw , Debska-Slizien Alicja 
Published: March 2018

AbstractEndothelial dysfunction could be related to the limited availability of nitric oxide (NO). NO is synthesized with the participation of an NO synthase whose activity is inhibited by asymmetric dimethylarginine (ADMA). The synthesis of ADMA is exacerbated by oxidative stress, and several studies have shown the efficacy of drugs acting on the renin-angiotensin-aldosterone system (RAAS) (converting enzyme inhibitors and angiotensin II receptor antagonists) in reducing the level of ADMA. The probable mechanism of drug action is a reduction of oxidative stress through a decrease of angiotensin II formation. The aim of this study was to assess the influence of RAAS blockers on the plasma concentration of ADMA in patients with chronic glomerulonephritis (ChGN). The study included 37 patients, placed into group A and group B, depending on the treatment. Both groups were treated with RAAS blockers. In group B, immunosuppressive drugs were additionally administered. The control visits were at the 0, 6 and 12 months of observation. In both the studied groups (A+B), a significant reduction of ADMA (0.77 vs 0.4 μmol/l; p<0.05) was noticed. In patients suffering from ChGN, the use of RAAS blockers resulted in a significant decrease of plasma ADMA concentration, independently of immunosupressive treatment.
Propuesta metodológica para articular la gestión documental con los requisitos de la Ley General de Archivos y la norma técnica internacional ISO 9001:2015
Authors: Puentes Poloche Maribel 
Published: March 2018

El objetivo de esta investigación fue elaborar una propuesta metodológica que permitiera articular la gestión documental cumpliendo con la Ley General de Archivos con la norma técnica de calidad ISO 9001:2015. Lo anterior, con el ánimo de que cualquier organización en Colombia implemente ambos sistemas sin que en la práctica surjan inconvenientes relacionados con el origen de la gestión documental como función archivística y el Sistema de Gestión de la Calidad como un enfoque por procesos. Como resultado de esta investigación, se hizo la elaboración de una propuesta metodológica para la articulación de la gestión documental con el Sistema de Gestión de la Calidad teniendo en cuenta los niveles estratégico, técnico y humano y, al interior de cada uno de ellos el ciclo PHVA. Además, un anexo para la alta dirección, quien toma las decisiones estratégicas y un segundo documento a coordinadores o personal encargado de lineamientos en materia documental y de gestión de calidad. Finalmente, la validación por juicio de expertos para que con sus conocimientos y experiencia se hiciera la versión final de la propuesta. La escogencia de la oficina del Convenio USTA–ICONTEC se hizo por el cumplimiento de las siguientes condiciones: implementación de ambos sistemas, fácil acceso a la documentación e información y la colaboración de funcionarios encargados de los lineamientos de calidad y de archivo. Sin embargo, la metodología propuesta es aplicable a cualquier otra entidad pública o privada que quiera implementar de manera articulada el Sistema de Gestión de la Calidad y la gestión documental, la cual debe cumplir con los requisitos de la Ley General de Archivos.
Guía para la implementación de NTC ISO 9001:2008, NTC ISO 14001:2004 y NTC OHSAS 18001:2007, basada en los hallazgos de las auditorías de certificación realizadas por el ICONTEC entre junio de 2012 y junio de 2015
Authors: Abreo Rojas Nicolai , Pinzón Rodríguez Nelson Nelson 
Published: March 2018

La presente investigación tiene como propósito orientar a las organizaciones, a través de una guía, en la identificación de los aspectos más relevantes a tomar en cuenta para asegurar la implementación, mantenimiento y mejora de la eficacia de los sistemas de gestión de la calidad, gestión ambiental y seguridad y salud ocupacional, basados en las normas ISO 9001:2008, ISO 14001:2004 y OHSAS 18001:2007. La información obtenida y analizada en la investigación, como elemento de entrada para la elaboración de la guía, corresponde a los informes de auditorías de tercera parte realizadas por el ICONTEC en el período de tiempo comprendido entre junio de 2012 y junio de 2015. La intención investigativa fue capitalizar las experiencias de las empresas con sistemas de gestión consolidados, a través de sus hallazgos de auditoría (no conformidades y aspectos por mejorar), en favor de empresas que se encuentran en cualquier etapa de implementación, con el fin de encontrar los elementos de gestión, y en algunos casos herramientas prácticas, que permitan una administración más eficaz. Se identificaron los temas de gestión que con mayor frecuencia presentaron desviaciones negativas, resultados que se pueden deber a varios factores como: rotación en las organizaciones de personal, errores de planificación de los procesos y actividades, falta de seguimiento o baja competencia de los auditores internos, pero los resultados muestran que existe dificultad en el aseguramiento de la implementación por parte de los responsables de estos aspectos, aún en sistemas de gestión maduros.
Az Érzelemszabályozás és az érzelmi intelligencia kapcsolata kognitív átkeretezési feladatban
Authors: Bodrogi Barbara , Bereczkei Tamás , Deák Anita 
Published: March 2018

Az affektív pszichológiában jelen lévő számos irányvonal rámutat az érzelmi jelenségek összetettségére, sokszínűségére. Az érzelemszabályozás és az érzelmi intelligencia szakirodalma az affektív folyamatok más-más aspektusára koncentrál. Az érzelemszabályozás leírja, milyen érzelmet élünk át, mikor és mennyire tartósan, valamint az átélt érzelmekből mit és hogyan fejezünk ki. Az érzelmi intelligencia (EQ) szakértői pedig az érzelmek azonosításában, megértésében, kifejezésében és szabályozásában megmutatkozó egyéni különbségeket kutatják. Jelen tanulmányban e két kutatási területet közelítettük egymáshoz. Az érzelmi intelligencia érzelemszabályozásra gyakorolt hatását vizsgáltuk önkitöltős kérdőívekkel és egy általunk kidolgozott, kognitív átkeretezést igénylő feladattal. A feladat során ugyanazt a képi ingert különböző hívószavakkal láttuk el, és arra kértük a személyeket, hogy ezek mentén képzeljék el a helyzetet, engedjék át magukat az érzéseiknek. Kognitív átkeretezési feladat előtt és után rögzítettük az érzelmi ingerekre adott válaszaikat, és megkérdeztük, mennyire volt nehéz az átkeretezés végrehajtása.
Eredményeink szerint kevesebb érzelemszabályozási nehézséget mutattak, és könnyebbnek találták az átkeretezési feladatot azok, akik magasabb pontot értek el az érzelmi intelligencia kérdőíven (szemben az alacsonyabb pontszámmal rendelkezőkkel). Az átkeretezés előtt kevésbé kellemes, intenzív érzésekről számoltak be, melyeket az átkeretezés eredményeképpen képesek voltak módosítani, mind a kellemesség tekintetében a pozitív érzelmek felé, mind az intenzitás tekintetében a csillapítás felé.
Mindezek alapján arra következtetünk, hogy az érzelmi intelligencia mértéke pozitívan befolyásolja az érzelemszabályozás folyamatát. A magasabb érzelmi intelligencia jelenléte valószínűsíti a hatékony és rugalmas regulációt. Továbbá kutatásunk alátámasztja azokat a korábbi kutatási eredményeket, melyek szerint a magas érzelmi intelligenciával rendelkezők elmélyülnek az érzelmekben, és elkerülés helyett „szembenéznek” a negatív affektív állapotokkal.
Mikrostruktur Dan Komposisi Fasa Pelet Sinter UO2 Dengan Penambahan Dopan Logam Zirkonium
Authors: Yulianto Tri , Mutiara Etty 
Published: March 2018

Telah dilakukan karakterisasi pelet UO2 sebagai bahan bakar PWR dengan penambahan dopan logam zirkonium pada pelet UO2. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan logam zirkonium terhadap mikrostruktur dan komposisi fasa pelet UO2 maupun stoikiometri (O/U) ratio. Logam zirkonium yang ditambahkan diharapkan terdistribusi merata dalam pelet UO2 sehingga dapat meningkatkan kualitas pelet UO2. Pelet UO2 difabrikasi dengan cara kompaksi dan penyinteran pada variasi penambahan logam zirkonium sebesar 0,3%, 0,5% dan 0,9% berat. Pelet UO2 hasil kompaksi kemudian disinter pada temperatur 17000C dengan laju pemanasan 250 0C/jam selama 3 jam dalam media campuran gas hidrogen. Pelet UO2 hasil sinter dikarakterisasi meliputi pengamatan visual, pengukuran densitas, pengamatan mikrostruktur menggunakan mikroskop optik dengan perbesaran 500x dan analisis fasa dengan difraksi sinar-X (XRD). Hasil analisis menunjukkan bahwa dengan penambahan dopan logam Zr sebesar 0,3%; 0,5% dan 0,9%berat tidak terdapat cacat maupun retak pada pelet UO2hasil sinter . Pelet sinter mempunyai rentang densitas 91% - 93% TD dan memenuhi persyaratan sebagai bahan bakar PWR. Sementara itu, hasil analisis mikrostruktur pelet UO2 dengan variasi persentase logam zirkonium diketahui bahwa keberadaan logam zirkonium tidak dapat dikonfirmasikan. Sementara itu, hasil evaluasi data uji XRD menggunakan perangkat lunak HighScore melalui pencocokan kurva hasil uji dengan struktur dari data base diperoleh struktur dan komposisi fasa dalam pelet hasil sinter. Fasa yang terbentuk pada pelet sinter UO2 tanpa penambahan Zr dan dengan variasi penambahan Zr adalah senyawa UO2 dan UO3. Fraksi senyawa UO3 dalam pelet sinter UO2 berbanding lurus dengan persentase penambahan zirkonium yang ditunjukkan oleh stoikiometrinya (O/U) berdasarkan fraksi fasa yang terbentuk.Kata kunci: pelet UO2 , logam Zr, densitas, mikrostruktur, komposisi fasa