bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management and Outcomes of Aortic Dissection in Pregnancy with Marfan Syndrome: A Systematic Review
Authors: Al-Thani Hassan , Mekkodathil Ahammed , El-Menyar Ayman 
Published: April 2019

Background:
In Marfan Syndrome (MFS), aortic dilatation is one of the main cardiovascular
manifestations which deteriorate due to the physiological changes during pregnancy. We aimed to assess
the up-to-date management and outcomes of aortic root dilation and dissection (AoD) in pregnancy
with MFS.

Patients and Methods:
A systematic review was conducted and reported according to the Preferred
Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Original studies published
between January 1, 2001 and December 31, 2018 and which described the management and/or outcomes
of AoD during or after pregnancy in women with MFS were included. Literature searches were
conducted. The PubMed search was performed using terms "Marfan Syndrome" [Mesh] and "Pregnancy"
[Mesh] whereas the Google Scholar search was for “Marfan” and “Pregnancy”, all words anywhere
in the article.

Results:
The literature search yielded 177 articles on PubMed and 13,900 articles on Google Scholar.
Assessment of full-text articles for eligibility after removal of duplicates from both databases yielded 12
eligible studies to be included in the final review.

Conclusion:
Women with MFS are at high risk of aortic dissection during pregnancy and women with
aortic root 41-45 mm should consider avoiding pregnancy. Guideline-specific management of aortic
aneurysms in pregnancy will reduce the risk of dissection. Diagnosis and Management of MFS need
a multidisciplinary approach and team that should start working early in pregnancy. Further studies are
needed to optimize medical and surgical approaches in addition to preconception counselling in highrisk
subjects.
Carbon Nanotubes Enhance the Chemotherapy Sensitivity of Tumors with Multidrug Resistance
Authors: Wang Zhijie , Tao Jinhua , Chen Jianan , Liu Qian 
Published: April 2019

Background:
Chemotherapy is the most important treatment method against cancer, in
addition to surgery and radiotherapy. However, Multidrug Resistance (MDR) in cancer always
results in the failure of chemotherapy. Effective chemotherapy agents need to be delivered
efficiently, distributed mostly in the tumor tissue, and highly internalized by tumor cells to eventually
inhibit proliferation or promote death of the tumor cells. A growing number of studies have indicated
that any defects that emerge during these steps could contribute to the occurrence of MDR in tumors.
Carbon Nanotubes (CNTs) are newly developed biocompatible materials that can be designed to
deliver anticancer agents by functionalizing the CNTs with drugs. Enhanced drug delivery efficiency
and improved treatment efficacy have been observed through CNT-based drug delivery systems.
However, some reports have shown that the simple administration of CNTs can reverse MDR in
cancer and enhance chemotherapy efficacy without anticancer agents attached to the surface of the
CNTs.

Objective:
Through an extensive review of previous reports in regard to CNTs and chemotherapy,
this paper aims to identify the various mechanisms of CNTs that inhibit MDR in cancer and enhance
chemotherapy sensitivity.

Results:
CNTs can increase the antitumor effects of chemotherapy agents. CNTs can not only
increase drug delivery accuracy and efficiency but also promote drug uptake, decrease drug efflux,
improve tumor hypoxia conditions, and induce autophagy and apoptosis in tumor cells, which make
the tumor more sensitive to antitumor agents.
Quality of Life and Mental Health of Infertile Women Affected by Endometriosis: A Narrative Review
Authors: Zarbo Cristina , Brugnera Agostino , Secomandi Rita , Candeloro Ilario , Malandrino Chiara , Betto Enrico , Bellia Adriano , Rabboni Massimo , Bondi Emi , Frigerio Luigi , Compare Angelo 
Published: April 2019

Objective:
Infertility has a severe impact on quality of life and mental health. This
condition could be exacerbated by the existence of comorbid medical disease, like endometriosis.
The aim of this critical narrative review is the examination of the state of the art about the quality of
life and mental health in infertile women with endometriosis.

Methods:
We performed a rigorous and systematic search for studies on multiple electronic databases.
A total of 6 papers were included in the review and were subjected to interpretative and critical
narrative synthesis.

Results and Discussion:
Major findings are resumed in the following points: (a) infertile women
with endometriosis when compared to infertile ones without endometriosis show higher depression,
stress perception, and anxiety, and lower general quality of life; (b) quality of life specifically related
to infertility is similar among women with and without endometriosis and seems to be related
to personality and beliefs factors; (c) giving birth to a child is related to better mental quality of life;
(d) during assisted reproductive treatment (ART) stimulation, infertile women with endometriosis
have a decrease of dysmenorrhea and dyspareunia; (e) satisfaction of ART is related to the number
of attempts, treatment accomplishment and pregnancy test outcomes. Clinical implications of these
findings and suggestions for future researches were discussed.

Conclusion:
Concluding, it is crucial to assess the psychological factors related to endometriosis and
infertility to reduce the impact of these diseases on quality of life and mental health, provide adequate
support to these patients, improve their satisfaction and increase the change to get pregnant.
A Review on Synthesis and Pharmacological Activity of Coumarins and Their Analogs
Authors: Gouda Moustafa A. , Salem Mohammed A. , Helal Mohamed H. 
Published: April 2019

Background:
Coumarins were reported to possess antimicrobial, antiinflammatory, antiplasmodial,
antimalarial, and enzyme inhibitory properties. Furthermore, coumarins are a type of vitamin K
antagonists. Coumarins had been first organized through perkin reaction; besides Knoevenagel condensation
was mentioned as a critical synthetic approach for the synthesis of 3-substituted coumarins.
Moreover, Pechmann, Reformatasky and Witting reactions were stated for the preparation of coumarins.

Methods:
We undertook a structured search of the method of preparation, the chemical reactivity and
biological properties that are associated with coumarins and their analogous.

Results:
Coumarins display a wide range of Src Kinase and cholinesterase inhibitor activities and
application of coumarins as antidiabetic, antipsychotic and antiproliferative agents has been addressed.
Other properties of coumarins such as their role in antitumor, anticancer, and as antioxidants have also
been reviewed.

Conclusion:
This review concluded that coumarin ring was mixed with other rings, a synergistic effect
for each of the ring in their biological activities was obtained, such compounds were exploited to improve
various important molecules which provide scaffolds for drug improvement. These compounds
were used to broaden a special molecule that gives scaffolds for drug improvement.
Concomitant Use of Cotrimoxazole and Atazanavir in HIV-infected Patients: A Therapeutic Drug Monitoring and Pharmacovigilance Based Dual Approach
Authors: Joe Miantezila B. , Roland Landman , Laurent Chouchana , Patrick Lê M. , Sawoo Olivier , Gaston Tona L. , Bruno Eto , Gilles Peytavin , Philippe Pochart 
Published: April 2019

Background:
Cotrimoxazole is the main antibiotic used in primary prophylaxis for
opportunistic infections in advanced HIV infection. This drug can inhibit one of the metabolic
pathways of atazanavir (ATV), such as the cytochromes P450 (CYP) 2C8/2C9 and could interfere
with its safety and efficacy.

Objective:
We studied the drug-drug interaction (DDI) between cotrimoxazole and ATV by using
therapeutic drug monitoring (TDM) and pharmacovigilance (PV) approaches.

Methods:
We compared a group of patients treated with cotrimoxazole and receiving an ATV-based
regimen to controls. This historical cohort analysis used data from Dat’AIDS in HIV-infected patients
who had at least two lowest plasma concentrations (C-trough) of ATV during their outpatient
follow-up. Likewise, we used the international pharmacovigilance data from VigiBase to evaluate
the notifications of hyperbilirubinemia reported with ATV.

Results:
In the TDM analysis, the two groups of patients (treated with cotrimoxazole and controls)
were almost homogeneous concerning the main baseline features. After at least six months of ATVbased
regimen, there was no significant difference in the safety threshold of the ATV C-trough
[with an adjusted odds ratio (aOR) of 1.4 (95% CI: 0.5 - 4.4)] compared to controls. We observed
similar results with the efficacy thresholds of ATV C-trough. Regarding the PV analysis, there was
no difference in hyperbilirubinemia occurring with ATV when cotrimoxazole was concomitant,
with an adjusted reporting odds ratio (aROR) of 0.9 (95% CI: 0.6 to 1.2).

Conclusion:
This study showed a relevant concomitant use between Cotrimoxazole and ATV based
on TDM and PV approaches.
Science-based Ethnic Bridging in Drug Development; Review of Recent Precedence and Suggested Steps Forward
Authors: van Hoogdalem Ewoud-Jan , Jones III John P. , Constant John , Achira Meguru 
Published: April 2019

Background:
Exposure, safety and/or efficacy of drugs are subject to potential differences
between human races or ethnicities, as acknowledged by regulatory guidance and by label
texts of various, but not all approved drugs.

Objective:
The objective of the present review was to assess recent regulatory precedence on drug
use and race or ethnicity, with the goal of identifying opportunities for increasing the informative
value of clinical ethnic or racial bridging in drug development.

Methods:
Recently, (January 2014-July 2018) FDA approved drug product label texts and approval
packages were reviewed for claims, comments and underlying data on use of the product in specific
ethnic or racial groups.

Results:
Among the 266 FDA-approved products, no product with unambiguous race- or ethnicity
specific dosing instructions was retrieved. A small majority (55%) was approved with a claim or
comment on race or ethnicity, and of these, a large majority (87%) was based on population pharmacokinetic
data analysis. Statements were often related to incidence of a genotype for drug metabolizing
enzyme or for other risk factors, or were related to body weight. Absence of clinically
relevant exposure differences were often justified in terms of exposure ratios that notably exceeded
the typical 0.80-1.25 no-effect boundary.

Conclusions:
Recent precedence reflected a pragmatic, descriptive approach of racial or ethnic
bridging, apparently meeting current regulatory expectations, whilst not resulting in strict guidance
to prescribers. We recommend further work on defining the objectives of bridging studies, as well
as criteria for their design and data analysis. Regarding the latter, we recommend investigating the
value of prospectively defined tests for similarity with appropriate follow-up analysis in the case
where the test has failed.
Integration and Querying of Heterogeneous Omics Semantic Annotations for Biomedical and Biomolecular Knowledge Discovery
Authors: Irshad Omer , Khan Muhammad Usman Ghani 
Published: April 2019

Background:Exploring various functional aspects of a biological cell system has been a focused research trend for last many decades. Biologists, scientists and researchers are continuously striving for unveiling the mysteries of these functional aspects to improve the health standards of life. For getting such understanding, astronomically growing, heterogeneous and geographically dispersed omics data needs to be critically analyzed. Currently, omics data is available in different types and formats through various data access interfaces. Applications which require offline and integrated data encounter a lot of data heterogeneity and global dispersion issues.Objective:For facilitating especially such applications, heterogeneous data must be collected, integrated and warehoused in such a loosely coupled way so that each molecular entity can computationally be understood independently or in association with other entities within or across the various cellular aspects.Methods:In this paper, we propose an omics data integration schema and its corresponding data warehouse system for integrating, warehousing and presenting heterogeneous and geographically dispersed omics entities according to the cellular functional aspects.Results & Conclusion:Such aspect-oriented data integration, warehousing and data access interfacing through graphical search, web services and application programing interfaces make our proposed integrated data schema and warehouse system better and useful than other contemporary ones.
Error Rate Performance of Potential Multicarrier Waveforms and Coding Techniques for 5G
Authors: Priya Bhanu , Malhotra Jyoteesh 
Published: April 2019

Background:
The wisdom of future wireless communication is clearly highlighted by the
gigabit experience, low latency and the three fold rises in the capacity, compared to the 4th Generation
networks. To meet such an ambitious objective of the 5th Generation communication systems,
efficient use of non-contiguous unused spectrum is required. The panacea to this issue lies in the
symbiosis of multicarrier waveforms and coding schemes.

Methods:
To study the interaction between these two, several multicarrier waveforms like Filtered-
OFDM (F-OFDM), Universal Filtered Multi-Carrier (UFMC) and Weighted Overlap and Add
(WOLA) which act as a powerful contender to win the 5G candidate waveform race, are analyzed in
Low-Density Parity Check Codes (LDPC), Polar and Turbo coded representative Third Generation
Partnership Project (3GPP) channel models under a common numerology framework. This article
dwells upon the error rate and throughput performance of different modulation formats and coding
schemes appropriate for the 5G in a well-defined multi-cellular environment.

Results and Conclusion:
The results have shown that even though many waveforms and coding
techniques may pave the route towards its adoption as a physical layer standard instead of classical
OFDM and convolution codes but no one is a clear conqueror as their selection depends upon the
considered environment and type of traffic.
Indoor Location Tracking Using Time of Arrival Estimation Method
Authors: Sreekumar Nandita , Sebastian Shoney 
Published: April 2019

Background & Objective:
Location-based services enable collection of location-oriented
information which finds use in various fields.

Methods:
With its utility found in so many applications, various localization techniques are adopted
to improve these services. One such property of a signal which is used for these estimations is known
as ‘Time of Arrival’ property. The ‘Time of Arrival’ property of a signal is the time difference for a
signal to go from the transmitter to the receiver. The most common application is to navigate through
places, finding or tracking your personal belongings, targeted advertisements by knowing the nearby
popular places and various other services like augmented reality gaming among others.

Results & Conclusion:
Through this paper, we demonstrate a method to track the location of a mobile
sensor node using Trilateration algorithm with the help of Time of Arrival (ToA) property of
signals. The time of arrival of packets at each node is recorded and data collected from the simulation
of a wireless sensor network for this experiment is spread across various distributions to find the optimum
statistical inference.
Hyaluronic Acid: The Reason for Its Variety of Physiological and Biochemical Functional Properties
Authors: Al-Khateeb Rami , Prpic Jelena 
Published: April 2019

Introduction:Many physicians may be unfamiliar with the importance of hyaluronic acid (HA) and its physiological and biochemical functions at cellular level. Despite the vast number of published studies using HA in medical treatments, it is still difficult for the reader to clearly distinguish the different types of HA employed in different medical applications. In addition, published studies do not mention the exact type of HA used or its biochemical properties. Usually, a study mentions only its molecular weight and concentration, which are insufficient to know its exact designed properties or to make a comparison with other types of HA.Methodology:This article is intended to summarise the information about native and modified HAs with a focus on explaining their different physiological and biochemical functions in the human body, their different commercially available types, and how they affect the associated medical applications. The goal is to provide a basis to researchers and physicians for distinguishing different types of HA and their properties in order to enhance physicians’ clinical practice in terms of application of different types of HA to treatments and to help the international research community to change the reporting of HA characteristics in published papers. This is necessary to enhance future acquisition of data, with the ability to create an HA data bank for further research and as a reference for different HA types and their medical applications.Conclusion:These developments should enhance the scientific and clinical knowledge about HA. Furthermore, the overall approach in this paper can be applied to other similar substances.
A STUDY OF THE AVAILABILITY OF MEDICINES FOR THE TREATMENT OF HIV-INFECTED PATIENTS IN THE REPUBLIC OF BASHKORTOSTAN
Authors: Mironenkova Zh. V. , Davletianova A. F. , Gabdulkhakova L. M. , Ilunova Y. G. , Ivakina S. N. , Yapparov R. G. 
Published: April 2019

According to the order of the Government of the Russian Federation of 01.12.2004 № 715 the disease caused by the virus of immunodeficiency of the person enter the list of socially significant diseases and the list of the diseases presenting danger to people around. Therefore, the aim of the research was to study the dynamics of the volume of procurement of medicines for the treatment of HIV-infected patients and the assortment availability of antiretroviral medicines in the Republic of Bashkortostan. The studies were conducted during the period of 2010–2016 years. The objects were the materials of reporting of the State Budget Health Agency Republican Center for Prevention and Control of AIDS and infectious diseases, electronic cards of government contracts. Methods of research: statistical, marketing, logic-economic, ATC/DDDs. The average growth rate in procurement of antiretroviral medicines is relatively the basic 2010 in monetary terms amounted to 168,52%. The largest share (1⁄2 part) were domestic medicines with one active substance. In value terms, there is a significant reduction of 26,74% in the volume of purchases of imported medicines with one active substance. At the same time, the import antiretroviral medicines were more in demand among combined antiretroviral medicines: their share increased by 28,56%. In natural terms, the share of domestic medicines with one active substance increased by 49,37%, in general, the share of the volume of antiretroviral medicines purchases of domestic production increased by 2,64 times. An analysis was conducted of the levels of management of assortment based on the calculation of the coefficients of the latitude of ARVs, regional mesocontours of domestic and imported ARVs of the six of the analyzed ATCgroups 4-th level were formed. The number of average daily doses of DDDs/1000 people/day for ARVs was calculated. It is established that the dominating in 2010–2016 there were ARVs of two ATC-subgroups: non-nucleoside — reverse transcriptase inhibitors (NNRTIs) and Nucleoside — reverse transcriptase inhibitors (NRTIs), which corresponds to the preferred first-line regimen for patients who had not previously taken antiretroviral therapy.
On the Space/Time of Information Literacy, Higher Education, and the Global Knowledge Economy
Authors: Nicholson Karen 
Published: April 2019

Local sites and practices of information work become embroiled in the larger imperatives and logics of the global knowledge economy through social, technological, and spatial networks. Drawing on human geography’s central claim that space and time are dialectically produced through social practices, in this essay I use human/critical geography as a framework to situate the processes and practices—the space and time—of information literacy within the broader social, political, and economic environments of the global knowledge economy.
As skills training for the knowledge economy, information literacy lies at the intersection of the spatial and temporal spheres of higher education as the locus of human capital production. Information literacy emerges as a priority for academic librarians in the 1980s in the context of neoliberal reforms to higher education: a necessary skill in the burgeoning “information economy,” it legitimates the role of librarians as teachers. As a strategic priority, information literacy serves to demonstrate the library’s value within the university’s globalizing agenda.
While there has been a renewed interest in space/time within the humanities and social sciences since the 1980s, LIS has not taken up this “spatial turn” with the same enthusiasm—or the same degree of criticality—as other social science disciplines. This article attempts to address that gap and offers new insights into the ways that the spatial and temporal registers of the global knowledge economy and the neoliberal university produce and regulate the practice of information literacy in the academic library.
Pre-print first published online 12/09/2018
Wages for Intern Work
Authors: Wildenhaus Karly 
Published: April 2019

While no comprehensive studies have yet been published quantifying the extent of unpaid internships within archives and libraries, their prevalence is easily recognized as widespread. Unpaid internships are offered and facilitated based on the implication that they correlate positively to future job prospects, although recent studies point to evidence that complicates this idea. Instead, the prevalence of unpaid internships may negatively impact efforts for diversity and inclusion among information workers while contributing to greater precarity of labor throughout the workforce. Meanwhile, professional organizations and academic programs often do not discuss the realities of unpaid internships, and some MLIS programs require or encourage students to work without remuneration for course credit at their own expense. Situating unpaid internships within larger questions of economic access, labor laws, indebtedness, and neoliberalization, this paper advocates for the denormalization of unpaid internships within archives and libraries, especially for those institutions that articulate social justice as part of their institutional values. Although rendering these positions obsolete is likely beyond the power of any one entity, this paper identify strategies that can be taken at the individual- and institutional-level to advance economic justice and the dignity of all work that occurs in our respective fields.
Pre-print first published online11/25/2018