bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable Hospitality Management and Dimensions of Environmental Regulations: A Qualitative Study on the Puducherry Perspective
Authors: Chandran R C Anu , Abraham Sherry 
Published: August 2019

Tourism and hospitality, globally, is experiencing a paradigm shift. The modern day tourists and clients of hospitality are very discerning and opt for higher quality and value based products and services. To cater to their needs, a wide range of properties at various scales are being introduced in the sector. At the same time, it is increasingly recognised that unplanned and uncontrolled hospitality ventures are causing certain adverse impacts on the environment. These necessitate thorough supervision of the hospitality projects, both existing as well as upcoming, and positively check whether they are abiding by the prescribed guidelines as prevailing under the environmental notifications. That is, the set up and operations must be actively monitored as per the Environmental Laws and Rules. The accelerated growth of international and domestic tourists to Puducherry resulted in the spurt of hospitality establishments across the destination. This growth can be sustained only if the hotels, resorts, restaurants and other hospitality outlets operate by showing profound consideration towards the environment. The business practices in the hospitality sector of Puducherry are undergoing great transformations, imbibing the latest and the best of things. Technological advancements have also altered traditional patterns and many innovative trends are emerging in the hospitality trade. With the increased impact on the environment owing to large scale establishment and expansion of hospitality projects in Puducherry, comes the need for informed planning and sustainable management as well as education and training for developers, investors, planners, managers and local communities. Owing to this reason, the management of hospitality firms in Puducherry must abide by the Environmental Laws and Rules to prevent haphazard, uncontrolled growth, spatial and land use planning; conforming to strict architectural controls, sewerage facilities and water treatment plants. This paper brings to light the challenges faced by the hospitality industry of Puducherry with regards to consumption and conservation of natural resources, by gathering and analysing the opinion of experts from the hospitality trade and the environmental pollution control organisations. This study elucidates the Environmental Laws and Rules which are necessary, as in the case of the hospitality industry of Puducherry, to curtail adverse effects on the environment. It is for sure that, in the future, quality practices and management styles as guided and enforced by the environmental laws would contribute to resolve many shortcomings faced by the hospitality enterprises in Puducherry.
Bridging the Gap between Producers and Consumers of Himachali Fruit Wines
Authors: Chauhan Suresh , Sharma Sukarn , Alene Yenesew 
Published: August 2019

Tourism is travel for recreational, leisure or business purposes. This vast industry is associated with different services like Accommodation, Food and Beverage services, Travel services, Recreation and Entertainment. These days tourists not only look for vacations and travel—they seek cultural education, historical significance, natural or inbuilt beauty, and to taste local cuisine and beverages. In Beverages especially, wines play an important role. Winemaking has existed throughout Indian history but was particularly encouraged by Portugal and the United Kingdom. The Old Testament in the Bible gives evidence of existence of wines, but there is a definite evidence of its use in China in 2000 BC and in Egypt in 3000 BC. Having a well established name in fruit juices, Himachal Pradesh (a northern hill state in India) has planned to venture in the area of fruit wines. To know the present position of Himachal’s wine industry and the gaps therein, a research was conducted. It was found that Himachal’s wine industry should address issues like availability of multiple flavours of fruit wines and stiff competition with beer and breezer. However, the industry can take advantage of three factors associated with these wines viz. health, flavour, and price. This can help Himachal to set up the same benchmark as it has done in case of juices.
Do Family Firms Invest More than Nonfamily Firms in Employee-Friendly Policies?
Authors: Kang Jun-Koo , Kim Jungmin 
Published: August 2019

We examine whether family firms invest more in employee relations than nonfamily firms. Using the variation in state-level changes in inheritance, gift, and estate taxes as an exogenous shock to family control, we find that family firms, particularly those in which a founder serves as chief executive officer or those in which a family member serves as a director on the board, treat their employees better than nonfamily firms. More importantly, family firms focus on investing in employee relations that help alleviate labor-related conflicts and controversies, possibly to avoid a negative family reputation among stakeholders. Family firms’ better treatment of their employees is also evident when we use a difference-in-difference test to exploit changes in family firm status due to (sudden) deaths of family members and firms’ inclusion in Fortune’s “100 Best Companies to Work For” list to identify employee-friendly treatment. We further find that family firms in the early stage of their life cycle invest more in employee relations when they operate in labor-intensive industries in which the benefits from family owners’ monitoring of employees are expected to be large. Moreover, we find that although nonfamily firms’ investment in employee relations is impeded by several constraints, such as short-term investor pressure, managerial myopia, and managerial agency problems, family firms do not suffer from such constraints. These findings help explain why underinvestment in employee relations is prevalent in public firms despite potential long-term benefits from such intangible investment. This paper was accepted by Neng Wang, finance.
Clearing Matching Markets Efficiently: Informative Signals and Match Recommendations
Authors: Ashlagi Itai , Braverman Mark , Kanoria Yash , Shi Peng 
Published: August 2019

We study how to reduce congestion in two-sided matching markets with private preferences. We measure congestion by the number of bits of information that agents must (i) learn about their own preferences, and (ii) communicate with others before obtaining their final match. Previous results suggest that a high level of congestion is inevitable under arbitrary preferences before the market can clear with a stable matching. We show that when the unobservable component of agent preferences satisfies certain natural assumptions, it is possible to recommend potential matches and encourage informative signals such that the market reaches a stable matching with a low level of congestion. Moreover, under our proposed approach, agents have negligible incentive to leave the marketplace or to look beyond the set of recommended partners. The intuitive idea is to only recommend partners with whom there is a nonnegligible chance that the agent will both like them and be liked by them. The recommendations are based on both the observable component of preferences and signals sent by agents on the other side that indicate interest. This paper was accepted by Yan Chen, decision analysis.
Complex Parkinson's disease: review and experiences
Authors: Cotterell Phil , Weight Debbie , Joseph Sharon , Joseph Paul 
Published: August 2019

The rate of Parkinson's disease progression is highly individual. It is important to identify those in the complex stage of the disease. Non-oral therapies may be appropriate for those in the complex stage of the disease who experience motor fluctuations, but there can be reasons for a failure to explore these options. Complex Parkinson's disease is a challenging time for the patient, their carer/s and for Parkinson's specialists. Changes to independence can be difficult to deal with, and the disease has an impact both physically and psychologically. For carers, the impact of Parkinson's can also result in physical and psychological issues, as well as social and financial problems. Consideration often turns to moving into a care environment, dealing with neuropsychiatric issues and challenging unmet need. Dealing with symptoms and problems using a team and a palliative approach is required.
Red Bag scheme evaluation—hospital transfer pathways and their relevance to HCAs
Authors: Graham Yitka , Keith Sarah , Freeman Maria , Haggerty Ken , Dimmock Kathryn , Hayes Catherine 
Published: August 2019

This article provides an insight into the evaluation of a hospital care transfer pathway, which was operationalised with the intention of improving information for healthcare professionals and local authority staff working in home and secondary care settings, such as hospitals. The evaluation of the Red Bag scheme provides timely reminders of the need for effective communication in any context of patient-centred care, the need for the capacity to keep learning and perhaps most importantly to remain reflective on practice every day. The article ends with 10 specific recommendations for all staff working in the context of hospital transfer, to ensure that optimal experience for patients can be assured as far as possible.
The effect of Streptococcus mutans on the Corrosion Behavior of Nickel-Titanium Dental Alloys - In Vitro Study
Authors: Marda Asmaa , Mouflih Khadija , Bellaouchou Abdelkebir , Guenbour Abdallah , Elmansari Asmae , Souly Karim , Zouhdi Mimoun , Zaoui Fatima , Bahije Loubna 
Published: August 2019

This study aimed to compare the resistance of dental alloys to corrosion in a solution containing oral bacteria named Streptococcus mutans (S.mutans). The electrochemical behavior of Nickel-Titanium (NiTi) was investigated in sterile Fusayama artificial saliva (AS) with the enrichment medium tryptic soy broth (TSB) in solution 1 and (AS) with (TSB) and bacteria in solution 2. The electrochemical procedures selected for this work were open circuit potentials (OCP), Potentiodynamic polarization (PDP), and electrochemical impedance spectroscopy (EIS). The NiTi surface was examined using optical microscopy.Â Â Â After 24 hours of immersion in artificial saliva, the results have shown that NiTi revealed high corrosion reactivity in the presence of S. mutans and present pitting corrosion on the surface.
Change in Brain Plasmalogen Composition by Exposure to Prenatal Undernutrition Leads to Behavioral Impairment of Rats
Authors: Hino Kodai , Kaneko Shunya , Harasawa Toshiya , Kimura Tomoko , Takei Shiro , Shinohara Masakazu , Yamazaki Fumiyoshi , Morita Shin-ya , Sato Shumpei , Kubo Yoshihito , Kono Tadaaki , Setou Mitsutoshi , Yoshioka Mina , Fujino Junya , Sugihara Hiroyuki , Kojima Hideto , Yamada Naoto , Udagawa Jun 
Published: August 2019

Epidemiological studies suggest that poor nutrition during pregnancy influences offspring predisposition to experience developmental and psychiatric disorders. Animal studies have shown that maternal undernutrition leads to behavioral impairment, which is linked to alterations in monoaminergic systems and inflammation in the brain. In this study, we focused on the ethanolamine plasmalogen of the brain as a possible contributor to behavioral disturbances observed in offspring exposed to maternal undernutrition. Maternal food or protein restriction between gestational day (GD) 5.5 and GD 10.5 resulted in hyperactivity of rat male adult offspring. Genes related to the phospholipid biosynthesis were found to be activated in the PFC, but not in the NAcc or striatum, in the offspring exposed to prenatal undernutrition. Corresponding to these gene activations, increased ethanolamine plasmalogen (18:0p-22:6) was observed in the PFC using mass spectrometry imaging. A high number of crossings and the long time spent in the center area were observed in the offspring exposed to prenatal undernutrition and were mimicked in adult rats via the intravenous injection of ethanolamine plasmalogen (18:0p-22:6) incorporated into the liposome. Additionally, plasmalogen (18:0p-22:6) increased only in the PFC, and not in the NAcc or striatum. These results suggest that brain plasmalogen is one of the key molecules to control behavior, and its injection using liposome is a potential therapeutic approach for cognitive impairment.SIGNIFICANCE STATEMENTMaternal undernutrition correlates to developmental and psychiatric disorders. Here, we found that maternal undernutrition in early pregnancy led to hyperactivity in rat male offspring and induced gene activation of phospholipid-synthesizing enzyme and elevation of ethanolamine plasmalogen (18:0p-22:6) level in the PFC. Intravenous injection of ethanolamine plasmalogen (18:0p-22:6) incorporated into the liposome maintained crossing activity and the activity was circumscribed to the center area for a long time period, as in prenatally undernourished offspring with aberrant behavior. Furthermore, the amount of ethanolamine plasmalogen (18:0p-22:6) increased in the PFC of the rat after injection. Our result suggests that brain plasmalogen is one of the key molecules to control behavior and that its injection using liposome is a potential therapeutic approach for cognitive impairment.
A placebo-controlled randomized study with testosterone in Klinefelter syndrome: beneficial effects on body composition
Authors: Høst Christian , Bojesen Anders , Erlandsen Mogens , Groth Kristian A , Kristensen Kurt , Jurik Anne Grethe , Birkebæk Niels H , Gravholt Claus H 
Published: August 2019

Context and objective
Males with Klinefelter syndrome (KS) are typically hypogonadal with a high incidence of metabolic disease, increased body fat and mortality. Testosterone treatment of hypogonadal patients decrease fat mass, increase lean body mass and improve insulin sensitivity, but whether this extends to patients with KS is presently unknown.

Research design and methods
In a randomized, double-blind, placebo-controlled, BMI-matched cross-over study, 13 males with KS (age: 34.8 years; BMI: 26.7 kg/m2) received testosterone (Andriol®) 160 mg per day (testosterone) or placebo treatment for 6 months. Thirteen age- and BMI-matched healthy controls were recruited. DEXA scan, abdominal computed tomography (CT) scan and a hyperinsulinemic–euglycemic clamp, muscle strength and maximal oxygen uptake measurement were performed.

Results
Total lean body mass and body fat mass were comparable between testosterone-naïve KS and controls using DEXA, whereas visceral fat mass, total abdominal and intra-abdominal fat by CT was increased (P < 0.05). Testosterone decreased total body fat (P = 0.01) and abdominal fat by CT (P = 0.04). Glucose disposal was similar between testosterone-naïve KS and controls (P = 0.3) and unchanged during testosterone (P = 0.8). Free fatty acid suppression during the clamp was impaired in KS and maximal oxygen uptake was markedly lower in KS, but both were unaffected by treatment. Testosterone increased hemoglobin and IGF-I.

Conclusion
Testosterone treatment in adult males with KS for 6 months leads to favorable changes in body composition with reductions in fat mass, including abdominal fat mass, but does not change measures of glucose homeostasis.
Speciális májműtét (Associating Liver Partition and Portal vein ligation for Staged hepatectomy, ALPPS) morbiditásának csökkentése átértékelt betegkiválasztási elvek és műtéttechnikai módosítás révén
Authors: Hahn Oszkár , Bárdos Dávid , Kupcsulik Péter , Szijártó Attila , Fülöp András , Kokas Bálint , Pekli Damján , Zsirka-Klein Attila , Dudás Ibolyka , Pajor Péter , Harsányi László 
Published: August 2019

Abstract: Introduction: Resecability of liver tumors is exclusively depending on the future liver remnant (FLR). The remnant can be hypertrophised using portal vein occlusion techniques. The latest hypertrophising method is Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS), which provides the most significant induced hypertrophy in the shortest time. Morbidity and mortality of this procedure were initially unacceptably high. Aim: Reducing complications by better patient selection and modified surgical technique. Method: The First Department of Surgery, Semmelweis University, Budapest, prefers the ‘no touch’ technique, instead of ‘complete mobilization’. For optimizing patient selection, an international registry (including our patients’ data) was established. In addition to the surgical, we collected demographic, disease, liver function, histology, morbidity (Clavien–Dindo) and mortality parameters. Volume and function measurements were performed by using CT-volumetry and 99mtechnecium-mebrofenin SPECT/CT. Data were analyzed by multivariate analysis (significance: p<0.05). Results: We performed 20 ALPPS procedures from 2012 to 2018. The relative volume increment and resectability in our department and among the 320 registry patients were 96% vs. 86% and 95% vs. 98%. Using ‘no touch’ technique, the Clavien–Dindo III–IV morbidity and mortality rates were significantly lower (22%–0%) than with ‘complete mobilization’ (63%–36%) (p<0.05). Based on the multivariate analysis of the registry patients, age over 60 years, liver macrosteatosis, non-colorectal liver tumor, >300 minutes operation time, >2 units of red blood cell transfusion, or insufficient FLR function before stage 2 were identified as independent factors influencing mortality (p<0.05). Conclusion: Mortality and morbidity of ALPPS can be reduced by proper patient selection and ‘no touch’ surgical technique. Orv Hetil. 2019; 160(32): 1260–1269.
An Analysis of Patients with DNA Repair Pathway Mutations Treated with a PARP Inhibitor
Authors: Borazanci Erkut , Korn Ronald , Liang Winnie S. , Guarnieri Carol , Haag Susan , Snyder Courtney , Hendrickson Kristin , Caldwell Lana , Von Hoff Dan , Jameson Gayle 
Published: August 2019

Abstract

Background
Molecular analysis has revealed four subtypes of pancreatic ductal adenocarcinoma (PDAC). One subtype identified for the presence of DNA damage repair deficiency can be targeted therapeutically with the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib. We performed a single institution retrospective analysis of treatment response in patients with PDAC treated with olaparib who have DNA damage repair deficiency mutations.

Subjects, Materials, and Methods
Patients with germline or somatic mutations involving the DNA repair pathway were identified and treated with olaparib. The primary objective was to examine the objective response rate (ORR). The secondary objectives were assessing tolerability, overall survival, and change in cancer antigen 19-9. Quantitative texture analysis (QTA) was evaluated from CT scans to explore imaging biomarkers.

Results
Thirteen individuals with metastatic PDAC were treated with Olaparib. The ORR to Olaparib was 23%. Median overall survival (OS) was 16.47 months. Four of seven patients with BRCA mutations had an effect on RAD51 binding, with a median OS of 24.60 months. Exploratory analysis of index lesions using QTA revealed correlations between lesion texture and OS (hepatic lesion tumor texture correlation coefficient [CC], 0.683, p = .042) and time on olaparib (primary pancreatic lesion tumor texture CC, 0.778, p = .023).

Conclusion
In individuals with metastatic PDAC who have mutations involved in DNA repair, Olaparib may provide clinical benefit. BRCA mutations affecting RAD51 binding domains translated to improved median OS. QTA of individual tumors may allow for additional information that predicts outcomes to treatment with PARP inhibitors.
Kinematics of Subduction Processes during the Earthquake Cycle in Central Chile
Authors: Aguirre Leonardo , Bataille Klaus , Novoa Camila , Peña Carlos , Vera Felipe 
Published: August 2019

ABSTRACTSubduction processes at convergent margins produce complex temporal and spatial crustal displacements during different periods of the earthquake cycle. Satellite geodesy observations provide important clues to constrain kinematic models at subduction zones. Here, we analyze geodetic observations in central Chile, where two large earthquakes occurred: 2010 Mw 8.8 Maule and 2015 Mw 8.3 Illapel. We propose a model that considers the motion along both interfaces of the brittle subducting slab as the sources responsible for the movement of the crust in the different periods of the earthquake cycle. Using standard inversion techniques, we provide a consistent framework of the kinematic displacement during each period of the earthquake cycle. We show that during the interseismic period prior to the Maule and Illapel earthquakes, two patches of slip rate on the lower interface are determined. These patches are located just below the future hypocenters. Because the interseismic period corresponds to the loading process and the coseismic to the unloading process, it is interesting to note that the area where loading is stronger corresponds to the area where unloading is also strong. Furthermore, we show that the Maule earthquake causes a significant displacement on the lower interface, just below the epicenter of the future Illapel earthquake to the north, a few years later. We speculate that the interaction between motions along both interfaces is the key to understanding the evolution of stress and the occurrence of earthquakes at subduction zones. This framework improves the understanding of the observed loading and unloading processes and potential triggering between subduction earthquakes.
ARTICULAÇÃO E REDES NO ENFRENTAMENTO À VIOLÊNCIA CONTRA AS MULHERES NO PARÁ
Authors: Souza Marcela Fernanda da Paz de , Henriques Frederico Oliveira 
Published: August 2019

O objetivo da pesquisa é verificar a formação de uma rede de enfrentamento à violência contra as mulheres do campo, das florestas e das águas no Estado do Pará. O estudo realiza o levantamento dos dados primários junto à CIPM-PA, e, baseando-se na abordagem de rede social, construi a rede geral com os 39 atores da CIPM-PA, subdivida entre o Fórum Estadual de Enfrentamento à Violência Contra as Mulheres do Campo, das Florestas e das Águas, o Conselho Estadual de Mulheres e o Comitê de Monitoramento do Pacto Nacional de Violência Contra a Mulher. A análise da rede social observou o clique e as medidas de centralidade de informação, de grau, de proximidade, de intermediação. Assim, é possível concluir que o estudo da formação da rede de enfrentamento e da proeminência dos atores poderá contribuir com processos decisórios e estratégias de ação direcionadas às mulheres dos contextos rurais.Palavras-chaves: Rede de Enfrentamento. Violência. Ruralidades