bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tooth Eruption into the Newly Generated Bone Induced by Recombinant Human Bone Morphogenetic Protein-2
Authors: Kitamura Atsushi , Motohashi Nobuyoshi , Kawamoto Tatsuo , Baba Yoshiyuki , Suzuki Shoichi , Kuroda Takayuki 
Published: October 2018

Objective The purpose of this study was to observe tooth eruption pattern into the newly generated bone induced by recombinant human bone morphogenetic protein-2 (rhBMP-2). Method Three 12-week-old beagle dogs were used. Following wound healing of the extracted maxillary third deciduous incisor at the age of 13 weeks, a resection of maxillary alveolar bone (8 mm by 8 mm by 8 mm) was carried out, accompanied by extraction of the maxillary second incisor tooth germ. The rhBMP-2 (5 μg/100 μL or 10 μg/100 μL) was implanted in the resected area. A group that was not implanted after resection and a nonresected group were used as controls. Serial changes of the eruption pattern of the maxillary third incisor in the implanted area were observed radiographically. Oxytetracycline and calcein were employed as bone markers. Nine weeks after the implantation, the animals were sacrificed. The samples were observed histologically and analyzed using peripheral quantitative computerized tomography to acquire the bone mineral density (BMD). Results In the rhBMP-2 (5 μg/100 μL)-treated group, histological findings and the BMD of the newly generated bone were almost same as in the non-resected group. The maxillary third incisor erupted through the implanted area. However, in the rhBMP-2 (10 μg/100 μL)-treated group, more osteoinductive activity and significantly higher BMD were observed in the newly generated bone. The maxillary third incisor erupted mesially so as to avoid this implanted area. Conclusion Results showed that bone remodeling and tooth eruption through the newly generated bone appear to be dose dependent. Accordingly, proper dosage of rhBMP-2 should be determined for successful clinical application.
Surgical Results of Primary Lip Repair Using the Triangular Flap Method for the Treatment of Complete Unilateral Cleft Lip and Palate: A Three-Dimensional Study in Infants to Four-Year-Old Children
Authors: Yamada Tomohiro , Mori Yoshihide , Minami Katsuhiro , Mishima Katsuaki , Tsukamoto Yuichi 
Published: October 2018

Objective: To evaluate morphological problems for children with complete unilateral cleft lip and palate (UCLP). Design and Setting: A cross-sectional study was performed on 46 patients with complete UCLP at Osaka University Dental Hospital. Patients and Participants: The method was applied to three groups of children with UCLP (8 4-month-old infants, 18 1.5-year-old children, and 20 4-year-old children). Main Outcome Measures: The three-dimensional coordinates of facial landmarks were extracted automatically from XYZ data sets and from photo images produced by an optical surface scanner. Results: The intercanthal distance, nose width, and mouth width were closer to those of normal children in the older group. Deviation of the columella toward the noncleft side was smaller in the 4-year-old group. The angle of the nasal tip was large in all groups. Asymmetry of the ala was conspicuous at the upper part of the nose in the vertical dimension. Asymmetry of the nostril was observed in the vertical dimension and in the anteroposterior dimension in the 4-year-old group. The angle of the Cupid's bow was obtuse on the non-cleft side, and the bottom of the Cupid's bow deviated toward the cleft side. The Cupid's bow was longer on the noncleft side. Protrusion of the vermilion was poor in all groups.
Three-Dimensional Analysis of Facial Morphology in Normal Japanese Children as Control Data for Cleft Surgery
Authors: Yamada Tomohiro , Mori Yoshihide , Minami Katsuhiro , Mishima Katsuaki , Tsukamoto Yuichi 
Published: October 2018

Objective: This study presents an analysis of three-dimensional facial forms of normal Japanese children. Design and Setting: Cross-sectional data (n = 247) were available from the Ikeda Public Health Center. Patients and Participants: Three groups of children (ninety-seven 4-month-old infants, fifty-four 1.5-year-old children, and eighty 3.5-year-old children) were analyzed using a three-dimensional anthropometric technique. Main Outcome Measures: Three-dimensional coordinates of facial landmarks were extracted automatically from XYZ data sets and photo images of an optical surface scanner. Results: Only minor gender differences were noted. Lip height was not correlated with other facial dimensions. There was a significant correlation between upper face, nose, and mouth widths. Compared with adults, the upper face width was larger (approximately 70% to 80% of adults) than the middle and lower parts of the face. Width ratios were greater than height and depth ratios. The lip height ratio, however, was larger than the lip width ratio, and the angle of the cupid's bow was more acute in children. The angle of the nose was more obtuse, particularly in the axial plane. Conclusions: In cleft lip surgery involving young children, there may be no need to consider gender differences. Some characteristic differences exist between children and adults, however, and normal standards for children would be helpful in plastic surgery.
Prognostic Implications of Nasal Cavity and Cleft Morphology in Secondary Bone Grafting
Authors: Kawakami Shingo , Hiura Kenji , Yokozeki Masahiko , Seike Takuya , Nakanishi Hideki , Moriyama Keiji 
Published: October 2018

Objective To examine the prognostic significance of the skeletal morphology around the nasal cavity and the alveolar cleft in secondary bone grafting (SBG). Design and Setting Fifty-one alveolar clefts in 41 patients (10 bilateral and 31 unilateral cleft lips and palates) registered in the Tokushima University Dental Hospital were examined in this study. Method Evaluation of the bony bridge after SBG using dental radiographs at 1 year after surgery. The clefts were divided into two groups: group I (54.9%) in which the upper border of the bony bridge was preferably maintained on or above the horizontal reference line (RL) constructed at the level of the root apex of the upper central incisor adjacent to the cleft, and group II (45.1%) in which the bone level was lower than the RL. Presurgical cleft width was determined by the dental radiographs. The cleft/nasal cavity ratio; the value of the cleft width divided by the nasal cavity width on the cleft side, which was analyzed by frontal cephalograms before the SBG; and the cleft/apertura piriformis ratio, the value analyzed by computed tomography, were used. Results and Conclusion The age, sex, and eruptive stage of the canine teeth at the time of the SBG showed no significant difference between groups. The presurgical cleft width also showed no significant difference between group I (6.6 ± 3.1 mm) and group II (7.9 ± 3.3 mm). The cleft/nasal cavity ratio showed a significant difference between groups I and II (0.42 ± 0.14, 0.75 ± 0.25; p < .05). Furthermore, the cleft/apertura piriformis ratio also showed a significant difference between groups I and II (0.32 ± 0.12, 0.65 ± 0.26; p < .05). These results suggested that measurements of the skeletal morphology around the nasal cavity and alveolar cleft might aid in predicting the stability of the bony bridge after SBG.
Deformational Posterior Plagiocephaly: Diagnosis and Treatment
Authors: Teichgraeber John F. , Ault Jeffrey K. , Baumgartner James , Waller Amy , Messersmith Marion , Gateño Jaime , Bravenec Brian , Xia James 
Published: October 2018

Objective This study was designed to evaluate the effectiveness of helmet therapy (DOC band) in the correction of patients with moderate to severe posterior deformational plagiocephaly. Design In this prospective study, the infants were evaluated using 18 anthropometric measurements. Patients The charts of 248 patients seen between August 1, 1995, and July 31, 1999, were reviewed, and 125 met the criteria for inclusion in the study. All the patients had posterior deformational plagiocephaly with no other craniofacial deformities or medical conditions. Treatment was instituted prior to 1 year of age, and all patients were compliant with DOC band usage and had complete anthropometric measurements. Results The study recorded a 41.56% (p < .001) reduction in cranial vault asymmetry and a 40.23% (p < .001) reduction in cranial base asymmetry. Orbitotragial asymmetry was improved 18.72% (p = .0738). The age at which treatment was begun was not a significant factor in predicting treatment outcomes.
Surgical Airway Management in Pierre Robin Sequence: Is There a Role for Tongue-Lip Adhesion?
Authors: Kirschner Richard E. , Low David W. , Randall Peter , Bartlett Scott P. , Mcdonald-Mcginn Donna M. , Schultz Patricia J. , Zackai Elaine H. , Larossa Don 
Published: October 2018

Objective The purpose of this study was to examine the efficacy of tonguelip adhesion (TLA) in the management of clinically significant airway obstruction associated with Pierre Robin sequence. Design The records of all children admitted to The Children's Hospital of Philadelphia with a diagnosis of Pierre Robin sequence were reviewed. Charts were reviewed for birth data, diagnosis, preoperative airway management methods, and surgical intervention. Records of infants undergoing TLA were analyzed for timing of surgery, operative technique, postoperative complications, length of hospital stay, and treatment outcome. Results Over the 28-year period 1971 to 1999, 107 patients (47 boys, 60 girls) meeting the criteria for Pierre Robin sequence were admitted for treatment. Of these, 74 (69.2%) were successfully managed by positioning alone. Surgical management of the airway was performed in the remaining 33 (30.8%) patients, 29 of whom underwent TLA and 4 of whom underwent tracheostomy. Dehiscence of the adhesion occurred in five patients (17.2%), two of whom subsequently required tracheostomy. Within the group of patients who underwent mucosal adhesion alone, the dehiscence rate was 41.6%. When the adhesion included muscular sutures, however, dehiscence was not observed in any patient. Of the 24 patients in whom primary TLA healed uneventfully, airway obstruction was successfully relieved in 20 (83.3%). Failure of a healed TLA to relieve the airway obstruction resulted in conversion to a tracheostomy in four patients. Six patients who underwent TLA (20.7%) ultimately required a tracheostomy; five of these patients (83.3%) were syndromic. Of patients requiring preoperative intubation, 42.9% ultimately required tracheostomy. Conclusion TLA successfully relieves airway obstruction that is unresponsive to positioning alone in the majority of patients with Pierre Robin sequence and should therefore play an important role in the management of these infants.
Submucous Cleft Palates Presenting with a Perforation
Authors: Mehendale Felicity V. , Sommerlad Brian C. 
Published: October 2018

Objective The development of a perforation in a submucous cleft palate (SMCP) is a rare occurrence, with only a few cases reported in the literature. We describe and illustrate four cases of SMCPs with a perforation in the palate. Results and Conclusions Recognition of the symptoms and signs of an SMCP should enable early diagnosis and treatment of this condition in symptomatic patients. However, in patients in whom the diagnosis has been missed or in those who have been asymptomatic, the development of a perforation may be the presenting feature of an SMCP. A history of possible trauma to the palate was found in two cases. Relatively minor trauma may cause perforation of the thin translucent central mucosa in an SMCP. In neonates, perforations surrounded by very thin mucosa may increase in size. The perforation can be closed at the same time as the SMCP repair and does not significantly alter the surgical treatment of an SMCP.
Dental Abnormalities, Bone Graft Quality, and Periodontal Conditions in Patients with Unilateral Cleft Lip and Palate at Different Phases of Orthodontic Treatment
Authors: Dewinter G. , Quirynen M. , Heidbüchel K. , Verdonck A. , Willems G. , Carels C. 
Published: October 2018

Objectives To evaluate the dental and periodontal condition of patients with unilateral cleft lip and palate (UCLP) before orthodontic treatment and evaluate whether the dental and periodontal condition of these patients during and after orthodontic treatment was jeopardized by the duration of the orthodontic and surgical treatment. Design Seventy-five individuals with UCLP (52 males, 23 females), between ages 8 and 20 years, participated in a retrospective study during their final follow-up visit with regard to dental abnormalities, such as hypodontia, external root resorption, crown and root malformation, and supernumerary teeth. Alveolar bone height and periodontal attachment loss on the cleft side were also screened before or after bone grafting and at different stages of orthodontic treatment. Results Hypodontia of the lateral incisor was found in more than 50% of the patients on the cleft side. Second premolars and/or lateral incisors outside the cleft area were missing in 27.2% of the patients. In 32%, malformations of the teeth near the cleft were noticed. In general, the teeth around and in the cleft of the patients showed normal septal bone heights and a healthy periodontium. Sixty of the 75 patients received a bone graft to restore the interrupted alveolar process. In 93.3% of these patients, the cleft was grafted before the eruption of the canine. Conclusion The periodontium of the teeth in and around the cleft in patients with UCLP observed during and after orthodontic treatment can cope relatively well with the long orthodontic treatment and combined surgical interventions. The children, who had not yet started treatment, also showed enough bone support and no periodontal problems of the teeth besides the cleft. Early secondary bone grafting seems to give optimal periodontal results.
A Fractal Analysis of Human Cranial Sutures
Authors: Yu Jack C. , Wright Ronald L. , Williamson Matthew A. , Braselton James P. , Abell Martha L. 
Published: October 2018

Objectives Many biological structures are products of repeated iteration functions. As such, they demonstrate characteristic, scale-invariant features. Fractal analysis of these features elucidates the mechanism of their formation. The objectives of this project were to determine whether human cranial sutures demonstrate self-similarity and measure their exponents of similarity (fractal dimensions). Design One hundred three documented human skulls from the Terry Collection of the Smithsonian Institution were used. Their sagittal sutures were digitized and the data converted to bitmap images for analysis using box-counting method of fractal software. Results The log-log plots of the number of boxes containing the sutural pattern, Nr, and the size of the boxes, r, were all linear, indicating that human sagittal sutures possess scale-invariant features and thus are fractals. The linear portion of these log-log plots has limits because of the finite resolution used for data acquisition. The mean box dimension, Db, was 1.29289 ± 0.078457 with a 95% confidence interval of 1.27634 to 1.30944. Conclusions Human sagittal sutures are self-similar and have a fractal dimension of 1.29 by the box-counting method. The significance of these findings includes: sutural morphogenesis can be described as a repeated iteration function, and mathematical models can be constructed to produce self-similar curves with such Db. This elucidates the mechanism of actual pattern formation. Whatever the mechanisms at the cellular and molecular levels, human sagittal suture follows the equation log Nr = 1.29 log 1/r, where Nr is the number of square boxes with sides r that are needed to contain the sutural pattern and r equals the length of the sides of the boxes.
Socioeconomic Status and Orofacial Clefts in Scotland, 1989 to 1998
Authors: Clark J. D. , Mossey P. A. , Sharp L. , Little J. 
Published: October 2018

Objective The purpose of this study was to investigate the association between socioeconomic status and orofacial clefts (OFC) in Scotland. Design Study of prevalence at birth over a 10-year period using an area-based measure of material deprivation. Setting Population-based study throughout Scotland. Participants Eight hundred thirty-four live births with OFC born between January 1, 1989, and December 31, 1998, ascertained from the nationwide register of the Cleft Service in Scotland, compared with the total 603,825 live births in Scotland in this period. Results There was a strong positive relationship whereby the prevalence of OFC at birth increased with increasing deprivation. This trend was statistically significant for cleft lip and/or palate (CL[P]: p = .016) but not for cleft palate (CP; p = .078). For each type of cleft, the relative risk among those resident in the most deprived areas, compared with those resident in the least deprived areas, was 2.33. Conclusions The association between OFC and socioeconomic status is consistent with a report for an earlier period in a smaller part of Scotland. Unlike the earlier study, this pattern appears to be stronger for CL(P) than for CP. These observations do not appear to be an artifact of recording. It is possible that they reflect the association between deprivation and risk factors for OFC, most likely tobacco smoking during pregnancy. Because the relationship between OFC and socioeconomic status appears to have been virtually unstudied in other populations, it would be valuable to investigate this relationship elsewhere and determine whether known risk factors account for the relationship.
The Effects of Active Infant Orthopedics on Occlusal Relationships in Unilateral Complete Cleft Lip and Palate
Authors: Chan Kathleen T. , Hayes Catherine , Shusterman Stephen , Mulliken John B. , Will Leslie A. 
Published: October 2018

Objective To evaluate the effects of active infant orthopedic treatment on dental arch relationships and determine the effect on maxillary growth in children born with unilateral complete cleft lip and palate (UCCLP). Design The GOSLON Yardstick was used to assess dental models taken on patients treated with and without active infant orthopedics. Patients Two groups of nonsyndromic Caucasian children born with UCCLP (total n = 40), all treated by the same surgeon and ranging from 5 to 10 years of age, were evaluated. Interventions One group had a Latham dentomaxillary alignment (DMA) appliance inserted at 5 to 6 weeks of age, after which a lip-nasal adhesion was performed at an average age of 3.5 months. This was followed by more definitive nasolabial repair at the average age of 5.9 months. Those patients treated without preoperative orthopedics underwent a lip-nasal adhesion at average age 1.5 months followed by nasolabial repair at average age 5.1 months. Main Outcome Measures Randomized assessments using the GOSLON Yardstick were done independently at two separate times by three different examiners. Differences in GOSLON scores between the active orthopedic group and nonorthopedic group were evaluated by both categorical and continuous statistical analyses. Results The mean GOSLON score was 3.30 for the orthopedic group and 3.21 for the nonorthopedic group. There was no significant group difference in the modal scores of the two groups. Conclusions This study showed that active infant orthopedics does not affect the dental arch relationships in preadolescent children with repaired UCCLP, compared with a similar group treated without orthopedic intervention at this center.
Orthopedically Induced Condylar Growth in a Patient with Hemifacial Microsomia
Authors: Sidiropoulou S. , Antoniades K. , Kolokithas G. 
Published: October 2018

Objective Hemifacial microsomia is a congenital abnormality that causes three-dimensional facial asymmetry, affection of the dental occlusion, and failure of growth of the midface in the growing child. This report outlines orthopedically induced condylar growth in a patient with hemifacial microsomia. Patient A 7-year-old girl with hemifacial microsomia, complete absence of the left mandibular condyle, and severe facial asymmetry was treated orthopedically in an early stage by means of a functional appliance. Functional therapy was instituted to stretch the deficient soft tissues to guide and promote skeletal growth and stimulate the affected areas. The treatment was completed with fixed appliances. Results The effect of the therapy was an excessive change in condylar growth in the affected side. Facial asymmetry was corrected and a symmetric mouth opening was established. Conclusions The treatment of patients with hemifacial microsomia should be initiated early enough so that the stimulus could in some degree normalize the deficient tissues and induce bone apposition, and in some cases surgical intervention could be avoided.
Vegetative regulation in the first three months of life in premature infants born with intrauterine growth retardation
Authors: Bliznetsova Elena A. , Antonova Liudmila K. , Malinin Alexandr N. 
Published: October 2018

Goal. To study the dynamics of vegetative states in preterm infants with intrauterine growth retardation (IUGR) during the first three months of life.
Materials and methods. Examined 34 preterm infants with IUGR – 1st group (GA – 33,3 ± 1,4 weeks, body weight – 1557,8 ± 63,8 g, length – 41,2 ± 1,7 cm) at the age of 5 days and 3 months of life; 51 premature infants without IUGR (GA – 33,2 ± 1,02 weeks, body weight 2062,0 ± 63,9 grams, length – 44,0 ± 1,4 cm) – 2nd group; a control group included 31 healthy full-term infants (GA – 38,8 ± 1,5 weeks, body weight – 3355,4 ± 147,6 grams, length – 52,7 ± 2,3 cm). The vegetative tester “Polispektr-8E/88” (2000 Hz, 12 bit), from the Russian firm “Neurosoft”, was used. Indicators of the cardiointervalogram (CIG) and spectrogram were determined in the baseline sample and in the orthostatic test (tilt-test).
Results. Among the indicators of CIG there was a noticeable decrease of mode (Mo, s) in 2 groups of preterm infants at 5 days of life (p < 0,05) and an increase in stress-index by 3 months of age in 1 group (p < 0,05). The study revealed the predominance in the structure of the wave spectrum of the VLF-component in all groups of children to 3 months; children 1 group had a lower value of this indicator, but they also had a higher proportion of high frequency component (HF, %) (p < 0,05). Vagotonic initial vegetative tonus (IVT) was defined only in 1 group, while the frequency of sympathicotonic and hypersympathicotonic IVT decreased (p < 0,05). Asympathicotonia vegetative reactivity (AST VR) in premature infants with IUGR was increased from 38, to 72,7% to 3 months (p < 0,05).
Conclusion. The study revealed the lack of influence of the Central contour vegetative regulation, more intense adaptation and high exhaustion of the functional reserve in preterm infants with IUGR to 3 months of life.
Hirschfeld surface analysis and short-range ferromagnetic ordering in La0.5Ca0.4Ag0.1MnO3 based on critical behavior study
Authors: Smari Mourad 
Published: October 2018

We investigated the Hirschfeld surface analysis and critical behaviour in La0.5Ca0.4Ag0.1MnO3 near the second-order ferromagnetic phase transition at Curie temperature TC. We determined the critical exponents, β, γ and δ corresponding to the temperature dependence of spontaneous magnetization, initial susceptibility and isothermal magnetization, respectively. The study of Hirshfeld surface reflects that both the electrostatic and intermolecular interactions are short range. The values for critical exponents obtained from magnetic measurements are very close to those predicted by the mean field tri-critical model. The critical-exponent values deduced here were in a good conform to those obtained using the modified Arrott plot and Widom scaling relation.