bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uterine Artery Doppler in Screening for Preeclampsia and Fetal Growth Restriction
Authors: Pedroso Marianna Amaral , Palmer Kirsten Rebecca , Hodges Ryan James , Costa Fabricio da Silva , Rolnik Daniel Lorber 
Published: June 2018

Objective To perform a comprehensive review of the current evidence on the role of uterine artery Doppler, isolated or in combination with other markers, in screening for preeclampsia (PE) and fetal growth restriction (FGR) in the general population. The review included recently published large cohort studies and randomized trials.
Methods A search of the literature was conducted using Medline, PubMed, MeSH and ScienceDirect. Combinations of the search terms “preeclampsia,” “screening,” “prediction,” “Doppler,” “Doppler velocimetry,” “fetal growth restriction,” “small for gestational age” and “uterine artery” were used. Articles in English (excluding reviews) reporting the use of uterine artery Doppler in screening for PE and FGR were included.
Results Thirty articles were included. As a single predictor, uterine artery Doppler detects less than 50% of the cases of PE and no more than 40% of the pregnancies affected by FGR. Logistic regression-based models that allow calculation of individual risk based on the combination of multiple markers, in turn, is able to detect ∼ 75% of the cases of preterm PE and 55% of the pregnancies resulting in small for gestational age infants.
Conclusion The use of uterine artery Doppler as a single predictive test for PE and FGR has poor accuracy. However, its combined use in predictive models is promising, being more accurate in detecting preterm PE than FGR.
A Pilot Study Evaluating Cerebral Vasculitis in Kawasaki's Disease
Authors: Yeom Jung Sook , Cho Young Hye , Koo Chung Mo , Jun Jin Su , Park Ji Sook , Park Eun Sil , Seo Ji-Hyun , Lim Jae-Young , Youn Hee-Shang , Woo Hyang-Ok 
Published: June 2018

AbstractCerebral vasculitis is thought to be a possible underlying mechanism of severe neurological complications of Kawasaki's disease (KD), such as cerebral infarct or aneurysm rupture. To evaluate the intracranial inflammatory response in patients with acute-stage KD, we measured the levels of cytokines (interleukin [IL]-6 and tumor necrosis factor [TNF]-α) and pentraxin-3 (PTX3) in the cerebrospinal fluid of patients with KD (n = 7) and compared the levels to those of the age- and sex-matched febrile control patients (bacterial meningitis [n = 5], enteroviral meningitis [n = 10], nonspecific viral illness without central nervous system involvement [n = 10]). PTX3 and TNF-α were rarely detected and only in trace concentration in KD, and the levels of IL-6 were not different from those of nonspecific viral illnesses. These mediators are not established biomarkers for cerebral vasculitis but might reflect vascular inflammation in various diseases including KD. Therefore, intracranial inflammation including vasculitis seems to be insignificant in our patients with KD. However, our results might be attributed to the fact that these patients lacked any clinical signs of cerebral or coronary vessel involvement. None of them underwent brain imaging. To clarify this issue, further studies involving patients with neurologic symptoms and proven involvement of cerebral vessels are needed.
Effect of breed and castration on production and carcass traits of male lambs following an intensive finishing period
Authors: Claffey Noel A , Fahey Alan G , Gkarane Vasiliki , Moloney Aidan P , Monahan Frank J , Diskin Michael G 
Published: June 2018

Abstract
The practice of crossbreeding using a terminal sire and the use of intact rather than castrated animals has the potential to increase the productivity of lambs produced from the hill sheep sector. The objective of this study was to compare the production and carcass characteristics of purebred Scottish Blackface (SB) and Texel cross Scottish Blackface (TXSB) ram and wether lambs fed on a concentrate diet and slaughtered at different ages. Two hundred spring born male lambs (average birth age ± SD 9.53 d) were assigned to a 2 × 2 factorial arrangement with two breeds SB (n = 100) and TXSB (n = 100) and two sexes (wether: n = 100 and ram: n = 100). Lambs were harvested following a 36 d ad libitum concentrate indoor finishing period. The study was carried out over five harvest batches between October and April. The mean ages of the lambs at harvest (n = 40; 20 TXSB and 20 SB lambs) in October, November, January, March, and April were 196, 242, 293, 344, and 385 days, respectively The TXSB lambs were heavier at slaughter than SB lambs (P &lt; 0.001), and ram lambs were heavier at slaughter than wether lambs (P &lt; 0.01). Improved ADG (P &lt; 0.001), lower feed conversion ratio (FCR) (which was calculated by dividing total feed intake by total weight gain; P &lt; 0.001), and higher feed intake (P &lt; 0.05) were recorded in TXSB lambs with consistency across the five harvest time points. Rams had greater ADG (P &lt; 0.001) and FCR (P &lt; 0.05) compared with wether lambs, and no differences were observed between sexes for feed intake. The TXSB (P &lt; 0.001) lambs had higher (P &lt; 0.001) dressing percentages compared with SB, while wether lambs had greater dressing percentages compared with rams. The TXSB lambs had heavier carcass weights (P &lt; 0.001) with higher conformation grades (P &lt; 0.001) and less fat cover (P &lt; 0.001) than SB lambs, while ram lambs had heavier (P &lt; 0.001) carcasses than wether lambs. There was greater fat cover on the loin muscles of SB (P &lt; 0.001) and wether (P &lt; 0.001) lambs compared with TXSB and ram lambs, respectively. The results from this study suggest that TXSB lamb’s offer hill sheep farmers a potential strategy for improved lamb production efficiency, while ram lambs offer lamb finishers increased growth rates, higher FCR, and produce a more desirable carcass than do wether lambs.
RAB-5 regulates regenerative axonal fusion by controlling EFF-1 endocytosis
Authors: Linton Casey , Neumann Brent , Giordano-Santini Rosina , Hilliard Massimo A. 
Published: June 2018

ABSTRACTFollowing a transection injury to the axon, neurons from a number of species have the ability to undergo spontaneous repair via fusion of the two separated axonal fragments. In the nematode C. elegans, this highly efficient regenerative axonal fusion is mediated by Epithelial Fusion Failure-1 (EFF-1), a fusogenic protein that functions at the membrane to merge the two axonal fragments. Identifying modulators of axonal fusion and EFF-1 is the next step towards harnessing this process for clinical applications. Here, we present evidence that the small GTPase RAB-5 acts to inhibit axonal fusion, a function achieved via endocytosis of EFF-1 within the injured neuron. Consequently, we find that perturbing RAB-5 activity increases the capacity of the neuron to undergo axonal fusion, through enhanced membranous localization of EFF-1 and the production of extracellular EFF-1-containing vesicles. These findings identify RAB-5 as a novel regulator of axonal fusion and the first regulator of EFF-1 in neurons.
CFTR misfolds during native-centric simulations due to entropic penalties of native state formation
Authors: Shi J. , Cleveland T. , Powe A. C. , McGaughey G. , Pande V. S. 
Published: June 2018

AbstractCystic fibrosis (CF) is a common genetic disorder that affects approximately 70,000 people worldwide. It is caused by mutation-induced defects in synthesis, folding, processing, or function of the Cystic Fibrosis Transmembrane conductance Regulator protein (CFTR), a chloride-selective ion channel required for the proper functioning of secretory epithelia in tissues such as the lung, pancreas, and skin. The most common cause of CF is the single-residue deletion of F508 (F508del), a mutation present in one or both alleles in 90% of patients that induces severe folding defects and results in greatly reduced expression of the protein. Despite its medical importance, high-resolution mechanistic information about CFTR folding is lacking. In this study, we used molecular dynamics simulation with a native-centric force field to examine the folding and assembly of both full-length CFTR and the isolated first nucleotide-binding domain (NBD1). We observed that the protein was capable of substantial misfolding on both the intradomain and interdomain scale due to entropically favorable kinetic traps that exist on CFTR’s folding free energy surface. These results suggest that even wild type CFTR, in the absence of any disease-related mutations, has suboptimal folding efficiency. We speculate that such entropically-driven misfolding also occurs in disease-prone mutants such as F508del and contributes to the protein’s poor in vivo activity.
Privacy protection laws and public perception of data privacy
Authors: Sarabdeen Jawahitha , Moonesar Immanuel Azaad 
Published: June 2018

Purpose
The move toward e-health care in various countries is envisaged to reduce the cost of provision of health care, improve the quality of care and reduce medical errors. The most significant problem is the protection of patients’ data privacy. If the patients are reluctant or refuse to participate in health care system due to lack of privacy laws and regulations, the benefit of the full-fledged e-health care system cannot be materialized. The purpose of this paper is to investigate the available e-health data privacy protection laws and the perception of the people using the e-health care facilities.

Design/methodology/approach
The researchers used content analysis to analyze the availability and comprehensive nature of the laws and regulations. The researchers also used survey method. Participants in the study comprised of health care professionals (n=46) and health care users (n=187) who are based in the Dubai, United Arab Emirates. The researchers applied descriptive statistics mechanisms and correlational analysis to analyze the data in the survey.

Findings
The content analysis revealed that the available health data protection laws are limited in scope. The survey results, however, showed that the respondents felt that they could trust the e-health services systems offered in the UAE as the data collected is protected, the rights are not violated. The research also revealed that there was no significance difference between the nationality and the privacy data statements. All the nationality agreed that there is protection in place for the protection of e-health data. There was no significance difference between the demographic data sets and the many data protection principles.

Originality/value
The findings on the users’ perception could help to evaluate the success in realizing current strategies and an action plan of benchmarking could be introduced.
Continuous improvement: challenges for the project-based organization
Authors: Backlund Fredrik , Sundqvist Erik 
Published: June 2018

Purpose
There are limited studies of continuous improvement (CI) from the perspective of a project-based organization (PBO). Hence, the purpose of this paper is to explore challenges that PBOs may encounter when applying CI.

Design/methodology/approach
An exploratory and qualitative approach has been used, involving six management teams in six different PBOs, using focus groups interviews as data collecting method.

Findings
A high degree of autonomy among project managers seems to limit a collective approach to project management in PBOs. As a consequence the overall PBO performance becomes subordinate to the individual project performance—an approach opposite to that of CI. Further, the management teams themselves seem to uphold a project focus, also complicating improvement initiatives from a PBO-perspective.

Research limitations/implications
The management teams have been the unit of analysis, where the PBOs mainly conduct projects in an engineering and construction context, and are located in the same country and region. This approach enables the thorough study of a phenomenon, while preconditions for generalization are limited. However, the findings could be used by researchers as a basis for more in-depth studies of specific challenges, and for making surveys to obtain generalization of results.

Practical implications
The results can induce awareness and understanding of different challenges if applying CI in a PBO, hence a starting point for finding ways to overcome these challenges.

Originality/value
The article contributes to an increased understanding of challenges that PBOs may encounter when applying CI, confirming and presenting additional findings compared to previous studies.
Pursuing the adoption pathway: the lived experiences of people living with HIV
Authors: Cane Tam , Vydellingum Vasso , Knibb Wendy 
Published: June 2018

Purpose
The purpose of this paper is to examine the experiences that people with HIV faced as they navigated through the intricate processes of trying to access adoption services in the south of England. It proposes the need to pay more attention to people living with HIV (PLWHIV) able to adopt children. The study aims to develop an increased focus on PLWHIV able to adopt.

Design/methodology/approach
The paper is an exploratory study using an interpretative phenomenological analysis (IPA) approach. Open-ended interviews were conducted with seven participants including individuals and couples. Interviews were transcribed and analysed using IPA’s cross-case and ideographic analysis.

Findings
The paper provides empirical insights about the challenges that PLWHIV experienced with social workers. Positive experiences were in the minority. Lack of information, inadequate support, stigma and discrimination, cultural insensitivity and disempowerment were frequently reported. The paper suggests that greater understanding and better education for social workers would improve access to adoption by people with HIV.

Research limitations/implications
Given the chosen approach and small sample size, results may not be generalisable.

Practical implications
This study increases knowledge, promotes positive attitudes and improved support for PLWHIV who are stable and able to offer permanency to adoptive children.

Originality/value
This paper provides new ideas in an area that is scarcely researched. It identifies the need to undertake further studies to understand how social workers assess PLWHIV and what can be done to provide adequate support.
17p12
Influences Hematoma Volume and Outcome in Spontaneous Intracerebral Hemorrhage
Authors: Marini Sandro , Devan William J. , Radmanesh Farid , Miyares Laura , Poterba Timothy , Hansen Björn M. , Norrving Bo , Jimenez-Conde Jordi , Giralt-Steinhauer Eva , Elosua Roberto , Cuadrado-Godia Elisa , Soriano Carolina , Roquer Jaume , Kourkoulis Christina E. , Ayres Alison M. , Schwab Kristin , Tirschwell David L. , Selim Magdy , Brown Devin L. , Silliman Scott L. , Worrall Bradford B. , Meschia James F. , Kidwell Chelsea S. , Montaner Joan , Fernandez-Cadenas Israel , Delgado Pilar , Greenberg Steven M. , Lindgren Arne , Matouk Charles , Sheth Kevin N. , Woo Daniel , Anderson Christopher D. , Rosand Jonathan , Falcone Guido J. ,   on behalf of the International Stroke Genetics Consortium
Published: June 2018

Background and Purpose—
Hematoma volume is an important determinant of clinical outcome in spontaneous intracerebral hemorrhage (ICH). We performed a genome-wide association study (GWAS) of hematoma volume with the aim of identifying novel biological pathways involved in the pathophysiology of primary brain injury in ICH.

Methods—

We conducted a 2-stage (discovery and replication) case-only genome-wide association study in patients with ICH of European ancestry. We utilized the admission head computed tomography to calculate hematoma volume via semiautomated computer-assisted technique. After quality control and imputation, 7 million genetic variants were available for association testing with ICH volume, which was performed separately in lobar and nonlobar ICH cases using linear regression. Signals with
P
<5×10
−
8
were pursued in replication and tested for association with admission Glasgow coma scale and 3-month post-ICH dichotomized (0–2 versus 3–6) modified Rankin Scale using ordinal and logistic regression, respectively.

Results—

The discovery phase included 394 ICH cases (228 lobar and 166 nonlobar) and identified 2 susceptibility loci: a genomic region on 22q13 encompassing
PARVB
(top single-nucleotide polymorphism rs9614326: β, 1.84; SE, 0.32;
P
=4.4×10
−8
) for lobar ICH volume and an intergenic region overlying numerous copy number variants on
17p12
(top single-nucleotide polymorphism rs11655160: β, 0.95; SE, 0.17;
P
=4.3×10
−8
) for nonlobar ICH volume. The replication included 240 ICH cases (71 lobar and 169 nonlobar) and corroborated the association for
17p12
(
P
=0.04; meta-analysis
P
=2.5×10
−9
; heterogeneity,
P
=0.16) but not for 22q13 (
P
=0.49). In multivariable analysis, rs11655160 was also associated with lower admission Glasgow coma scale (odds ratio, 0.17;
P
=0.004) and increased risk of poor 3-month modified Rankin Scale (odds ratio, 1.94;
P
=0.045).

Conclusions—

We identified
17p12
as a novel susceptibility risk locus for hematoma volume, clinical severity, and functional outcome in nonlobar ICH. Replication in other ethnicities and follow-up translational studies are needed to elucidate the mechanism mediating the observed association.
Scribal Correction Dots on an Unpublished Elephantine Aramaic Papyrus Fragment
Authors: Moore James D. 
Published: June 2018

Abstract
In a box of unpublished Aramaic papyri from the 1906–1907 German excavations of Elephantine there is a small fragment (p. 23141) that uses scribal marks in a margin or vacat to identify a textual edit. This is the first example of Aramaic editorial marks of this type from the Persian period, and demonstrates a previously unidentified scribal practice.
Šiuolaikinė Azerbaidžano pensijų sistema: reformos ir iššūkiai
Authors: Bitinas Audrius 
Published: June 2018

The aim of this article is to define the legislationAzerbaijan state social security pension system and latest reforms, influenced by the recent economic crisis and demographic – social challenges, and to provide with the conclusionsin the state social guarantees context. In this paper author analyses challenges and presents conclusions and recommendations for further pension system reforms in Azerbaijan.
The Virtual Trojan Horse in Modern Conflicts
Authors: Al-Aridi Alaa 
Published: June 2018

The article will examine the applicability of international laws to cyber affairs by focusing on cyber-attacks that fall under the jus ad bellum the law relating resort to the use of force in the cyber field; and analyzing the applicability of article 2/4 of the UN charter as well the right to self-defense articulated in article 51 of the UN charter; on the other hand will analyze how the legal parameters of IHL (jus in bello) apply to cyber operations in armed conflicts.
Message from editor
Authors: Bozkurt Prof. Dr. Tulay 
Published: June 2018

Message from Editor
Dear Readers,
It is a great honor for us to publish seventh volume, second issue of Global Journal of Psychology Research: New Trends and Issues (GJPR).
Global Journal of Psychology Research: New Trends and Issues welcomes original empirical investigations and comprehensive literature review articles focusing on psychological issues and related disciplines. The mission of the journal is to publish articles of professional interest for members of psychology. The scope of the journal includes, but is not limited to; the following major areas of psychology science including clinical psychology, developmental psychology, social psychology, experimental psychology, industrial and organizational psychology, traffic psychology, forensic psychology, psychometric psychology, sports psychology, health psychology, educational psychology, media psychology and neuroscience psychology.
Articles focusing on loneliness levels of college students, trauma in cultural contexts, relationships between violent video games and cognition, Turkish adaptation and validation of Spielbergerâ€™s State Anger Subscale, writing skill difficulties for 'beginner' learners of the Arabic Language, valuing the educational changes in the Romanian educational system, relationship between gender and socio-economic level factors with psychological disorders in adolescents in Turkey and changing spatial belongings among migrantsâ€™ generations are included in this issue. The topics of the next issue will be different. You can make sure that we will be trying to serve you with our journal with a rich knowledge in which different kinds of topics are discussed in 2017 Volume.
A total number of twenty (20) manuscripts were submitted for this issue and each paper has been subjected to double-blind peer review process by the reviewers specialized in the related field. At the end of the review process, a total number of eight (8) high quality research papers were selected and accepted for publication.
We present many thanks to all the contributors who helped us to publish this issue.

Best regards,

Prof. Dr. Tulay Bozkurt

Editor â€“ in Chief
The Role Perceptions of Newly Appointed Senior School Leaders in the Western Cape, South Africa and Abu Dhabi United Arab Emirates: A Comparative Case Study
Authors: Van Vuuren Nelius Jansen 
Published: June 2018

The role of the senior school leader, in school leadership teams, has been intensely deliberated over the years. Professional learning and leadership approaches and experiences for newly appointed senior school leaders have been extensively linked to the role perceptions of new school leaders. The importance of appropriate recommendations for policy and practice highlight the need for complex developmental support ingenuities to support their perceived development needs. Extensive teaching experience may be the only requirement for being appointed as a senior school leader, as also suggested by the Western Cape Education system (WCED). A developing system such as the Abu Dhabi Education Council (ADEC) system, highly qualified individuals make up for a lack of experience. Both these perceptions support the notion that no further professional development is required for newly appointed school leaders, the problem addressed in this paper. This article report and compare the main findings of the perceived roles and responsibilities of newly appointed senior school leaders in the Western Cape, South Africa, and Abu Dhabi, United Arab Emirates (UAE). The perceived roles and responsibilities of newly appointed school leaders, suggest a unique and specialist development approach to support effective leadership. The outcomes of this study further suggest a need for contextualised, individualised training and support in their individualised roles and responsibilities. The paper, therefore, employs a mixed-method approach to gather data to understand the perceived roles and responsibilities of newly appointed senior school leaders in the Western Cape, South Africa and Abu Dhabi, UAE.