bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Novel T1D Risk Loci and Their Association With Age and Islet Function at Diagnosis in Autoantibody-Positive T1D Individuals: Based on a Two-Stage Genome-Wide Association Study
Authors: Zhu Meng , Xu Kuanfeng , Chen Yang , Gu Yong , Zhang Mei , Luo Feihong , Liu Yu , Gu Wei , Hu Ji , Xu Haixia , Xie Zhiguo , Sun Chengjun , Li Yuxiu , Sun Min , Xu Xinyu , Hsu Hsiang-Ting , Chen Heng , Fu Qi , Shi Yun , Xu Jingjing , Ji Li , Liu Jin , Bian Lingling , Zhu Jing , Chen Shuang , Xiao Lei , Li Xin , Jiang Hemin , Shen Min , Huang Qianwen , Fang Chen , Li Xia , Huang Gan , Fan Jingyi , Jiang Zhu , Jiang Yue , Dai Juncheng , Ma Hongxia , Zheng Shuai , Cai Yun , Dai Hao , Zheng Xuqin , Zhou Hongwen , Ni Shining , Jin Guangfu , She Jin-Xiong , Yu Liping , Polychronakos Constantin , Hu Zhibin , Zhou Zhiguang , Weng Jianping , Shen Hongbing , Yang Tao 
Published: May 2019

OBJECTIVE
Type 1 diabetes (T1D) is a highly heritable disease with much lower incidence but more adult-onset cases in the Chinese population. Although genome-wide association studies (GWAS) have identified &gt;60 T1D loci in Caucasians, less is known in Asians.

RESEARCH DESIGN AND METHODS
We performed the first two-stage GWAS of T1D using 2,596 autoantibody-positive T1D case subjects and 5,082 control subjects in a Chinese Han population and evaluated the associations between the identified T1D risk loci and age and fasting C-peptide levels at T1D diagnosis.

RESULTS
We observed a high genetic correlation between children/adolescents and adult T1D case subjects (rg = 0.87), as well as subgroups of autoantibody status (rg ≥ 0.90). We identified four T1D risk loci reaching genome-wide significance in the Chinese Han population, including two novel loci, rs4320356 near BTN3A1 (odds ratio [OR] 1.26, P = 2.70 × 10−8) and rs3802604 in GATA3 (OR 1.24, P = 2.06 × 10−8), and two previously reported loci, rs1770 in MHC (OR 4.28, P = 2.25 × 10−232) and rs705699 in SUOX (OR 1.46, P = 7.48 × 10−20). Further fine mapping in the MHC region revealed five independent variants, including another novel locus, HLA-C position 275 (omnibus P = 9.78 × 10−12), specific to the Chinese population. Based on the identified eight variants, we achieved an area under the curve value of 0.86 (95% CI 0.85–0.88). By building a genetic risk score (GRS) with these variants, we observed that the higher GRS were associated with an earlier age of T1D diagnosis (P = 9.08 × 10−11) and lower fasting C-peptide levels (P = 7.19 × 10−3) in individuals newly diagnosed with T1D.

CONCLUSIONS
Our results extend current knowledge on genetic contributions to T1D risk. Further investigations in different populations are needed for genetic heterogeneity and subsequent precision medicine.
TIPOLOGI ARSITEKTUR RUMAH SABU (AMMU HAWU), SEBUAH PENDEKATAN DESKRIPTIF ANTROPOLOGIS
Authors: Jeraman Pilipus 
Published: May 2019

Abstract: The architecture of the house of Sabu (ammu hawu) is one of the riches of vernacular architecture that still exists in East Nusa Tenggara and is well preserved by the ethnic Sabu community, which inhabits the islands of Sabu and Raijua Island. This research provides a descriptive description of the typological characteristics of Sabu's house architecture (ammu hawu) and its settlement environment. The typology study on Sabu house (ammu hawu) was developed with a descriptive anthropological approach. The results showed that the architecture of the house of Sabu (ammu hawu) has distinctive characteristics that are in harmony with the cultural background of the Sabu community. Based on the typology of functions and forms known to the typology of houses on Sabu island there are three typologies, namely ammu hawu (roukoko), ammu atta, and ammu jawa.Keywords: typology, ammu hawu, descriptive, anthropologicalAbstrak: Arsitektur rumah Sabu (ammu hawu) adalah salah satu kekayaan arsitektur vernakular yang masih eksis di Nusa Tenggara Timur dan terpelihara dengan baik oleh masyarakat etnis Sabu, yang mendiami Pulau Sabu maupun Pulau Raijua. Penelitian ini memberi gambaran deskriptif tentang karakteristik tipologi arsitektur rumah Sabu (ammu hawu) dan lingkungan permukimannya. Kajian tipologi terhadap rumah Sabu (ammu hawu) ini dikembangkan dengan pendekatan deskriptif antropologis. Hasil penelitian menunjukkan, arsitektur rumah Sabu (ammu hawu) memiliki karakteristik khas yang selaras dengan latar belakang kebudayaan masyarakat Sabu. Berdasarkan tipologi fungsi dan bentuk diketahui tipologi rumah di pulau Sabu ada tiga tipologi, yakni ammu hawu (roukoko), ammu atta, dan ammu jawa. Kata kunci: tipologi, ammu hawu, deskriptif, antropologis.
Some Properties of Green’s Matrix of Nonlinear Boundary Value Problem of First Order Differential
Authors: Badrulfalah Badrulfalah , Susanti Dwi , Joebaedi Kafsah , Kosasih Robin 
Published: May 2019

This paper discusses Green’s matrix of nonlinear boundary value problem of first-order differential system with rectangular coeffisients, especially about its properties. In this case, the differential equation of the form with boundary conditions of the form and which is a real matrix with whose entries are continuous on and . , are nonsingular matrices such that and are constant vectors. To get the Green’s matrix and the assosiated generalized Green’s matrix, we change the boundary condition problem into an equivalent differential equation by using the properties of the Moore-Penrose generalized inverse, then its solution is found by using method of variation of parameters. The last we prove that the defined matrices satisfy the properties of green’s function. The result is the corresponding the Green’s matrix and the assosiated generalized Green’s matrix have the property of Green’s functions with the jump-discontinuity.
Simulations for Resource-Allocation Protocol Optimization for MIL-STD-188-186 over a UHF SATCOM Network
Authors: Chandler Edward William 
Published: May 2019

A simple simulation tool was previously developed to simulate the operation and performance of demand-assigned communication networks having time-varying data traffic patterns. Such networks use protocols to increase or decrease the resources allocated to a network node as the resource needs at that node change. These resource-allocation protocols have parameters such as numerical thresholds for requesting or releasing resources. The additional simulator development and execution described herein allows a comparison of performance metrics that result when using the existing MIL-STD-188-186 protocol versus using a proposed alternative protocol. The network behavior revealed by the simulation results also allows examining network performance trade-offs as values for the protocol parameters are adjusted. Although commercially available simulation tools could be used for these simulations, such tools are often expensive and sometimes complicated to adapt to new and not yet standardized protocols. The simple simulation tool that was previously developed is described in an earlier paper and is programmed as an Excel spreadsheet. It has now been adapted to allow comparing an existing resource-allocation protocol versus a proposed protocol for MIL-STD-188-186. The simulator allows examination of performance metrics such as the average number of assigned time slots per frame assigned to a transmitting node that has a specified message generation rate, the percentage of generated messages that are discarded prior to transmission due to being queued for an excessive time, and a histogram showing the percentage of messages transmitted with each possible message delivery time.
Determination of Engineering Geological Conditions of A Plant-Site: A Case Study in an Open Pit Mine in Çine, Aydın
Authors: Karagöz Saffet Deniz , Koca Yalçın 
Published: May 2019

A plant will be constructed between the Alipasa and Sarıkısık feldspar open-pit mines in Karpuzlu-Çine (Aydın) to conduct the works of crushing-grinding and flotation. An investigation was carried out to determine engineering geological conditions at and below the plant-site using scan-lines, geophysical measurements, and three inclined borehole data. Geological structure and ground conditions including geotechnical data such as discontinuity frequency and spacing, RQD% and CR% acquired from the drill hole exploration and geophysical survey are determined. Along the inclined drill holes, true discontinuity spacing values computed for each core run represent the most intersected discontinuities. In these calculations, determination of the acute angles between the axes of drill holes and strikes of the discontinuity sets are important as much as the investigation of fracture distributions in the subsurface. For this reason, the stereographic projection techniques were used to determine the true acute angle in this work. The purpose of the investigation is to identify and mitigate difficulties caused by ground conditions. The rock conditions comprise heavily jointed and weathered metamorphic rocks and the ability of these to support the foundations is considered. It was determined that the bearing capacity values obtained from the geotechnical computations considering RQD values agree with the ones acquired from the geophysical measurements, except the weakness zones (sheared zones). It was also determined that the values of allowable bearing pressure based on the geotechnical works are more conservative than the ones from the geophysical measurements. When all results are considered, the ratio between the allowable bearing capacity (qa) values acquired from geotechnical and geophysical measurements is close to 0.65.
Recovery characteristics of dogs following anesthesia induced with tiletamine-zolazepam, alfaxalone, ketamine-diazepam, or propofol and maintained with isoflurane
Authors: Hampton Chiara E. , Riebold Thomas W. , Mandsager Ronald E. 
Published: May 2019

Abstract
OBJECTIVE To compare characteristics of recovery from isoflurane anesthesia in healthy nonpremedicated dogs after anesthetic induction by IV administration of tiletamine-zolazepam with those observed after induction by IV administration of alfaxalone, ketamine-diazepam, or propofol.
DESIGN Prospective, randomized crossover study.
ANIMALS 6 healthy adult hounds.
PROCEDURES Each dog underwent the 4 treatments in random order with a ≥ 7-day washout period between anesthetic episodes. Anesthesia was induced by IV administration of the assigned induction drug or combination (each to effect in 25% increments of calculated dose) and maintained with isoflurane in oxygen for 60 minutes. Cardiorespiratory variables and end-tidal isoflurane concentration (ETISO) were measured just before isoflurane administration was discontinued. Dogs were observed and video recorded during recovery. Recovery characteristics were retrospectively scored from recordings by 3 raters. Interrater and intrarater reliability of scoring was assessed by intraclass correlation coefficient calculation. Linear and mixed ANOVAs were used to compare extubation times, recovery scores, and body temperature among treatments.
RESULTS Most cardiorespiratory variables, body temperature, ETISO, and time to extubation did not differ between tiletamine-zolazepam and other induction treatments. Recovery scores were lower (indicating better recovery characteristics) with propofol or alfaxalone than with tiletamine-zolazepam but did not differ between tiletamine-zolazepam and ketamine-diazepam treatments. Anesthetic episode number and ETISO had no effect on extubation time or recovery score. Intrarater and interrater correlations for recovery scores were excellent.
CONCLUSIONS AND CLINICAL RELEVANCE Recovery of healthy dogs from anesthesia with isoflurane after induction with tiletamine-zolazepam was uncomplicated and had characteristics comparable to those observed following induction with ketamine-diazepam. However, recovery characteristics were improved when anesthesia was induced with propofol or alfaxalone.
Evaluation of the anesthetic and cardiorespiratory effects of intramuscular alfaxalone administration and isoflurane in budgerigars (Melopsittacus undulatus) and comparison with manual restraint
Authors: Balko Julie A. , Lindemann Dana M. , Allender Matthew C. , Chinnadurai Sathya K. 
Published: May 2019

Abstract
OBJECTIVE To evaluate the anesthetic and cardiorespiratory effects of IM alfaxalone and isoflurane administration in budgerigars (Melopsittacus undulatus) and compare use of these agents with use of manual restraint.
ANIMALS 42 healthy budgerigars.
PROCEDURES For dose comparison, birds received alfaxalone (5 or 10 mg/kg [2.27 or 4.54 mg/lb], IM; groups A5 and A10, respectively; n = 6/group). For treatment comparison, birds received alfaxalone (10 mg/kg, IM) or isoflurane (via face mask) or were manually restrained (groups A, I, and M, respectively; n = 10/group). Data were obtained on onset, degree, and duration of sedation or anesthesia; heart and respiratory rates; and recovery times. Birds in the treatment comparison underwent physical examination and blood gas analysis.
RESULTS All group A5 birds became sedate, but not recumbent. In group A10, 5 of 6 birds lost the righting reflex; however, none lost the noxious stimulus response. Median time to initial effects was significantly shorter and mean time to complete recovery was significantly longer in group A10 than in group A5. Heart and respiratory rates in group A10 remained clinically acceptable; however, some birds had signs of excitement during induction and recovery. Times to initial effects, recumbency, and complete recovery were significantly longer, yet clinically practical, in group A than in group I. Plasma lactate concentrations were significantly higher in group M than in groups A and I.
CONCLUSIONS AND CLINICAL RELEVANCE Alfaxalone administered IM at 10 mg/kg produced effective sedation in healthy budgerigars and may be a viable alternative to isoflurane and manual restraint for brief, minimally invasive procedures. Brief manual restraint resulted in a significant increase in plasma lactate concentration.
PUTUSAN PENINJAUAN KEMBALI PERKARA PIDANA SEBAGAI NOVUM DALAM PENINJAUAN KEMBALI PERKARA PERDATA
Authors: HSB ALI MARWAN 
Published: May 2019

ABSTRAKUndang-Undang Nomor 15 Tahun 2001 tentang Merek mengatur bahwa untuk penyelesaian sengketa atau pelanggaran merek dapat ditempuh melalui dua alternatif penyelesaian, yaitu dengan mengajukan gugatan ke pengadilan niaga (secara perdata) dan diadukan kepada penyidik untuk diselesaikan secara pidana. Kedua penyelesaian inilah yang ditempuh sekaligus oleh GG melawan GB. Kasus ini kemudian sampai pada upaya hukum luar biasa yaitu peninjauan kembali. Dalam peninjauan kembali perkara perdata, pihak GG mengajukan putusan peninjauan kembali perkara pidana sebagai novum. Berdasarkan hal tersebut, dapat dirumuskan permasalahan dalam tulisan ini adalah: apakah putusan peninjauan kembali perkara pidana dapat dijadikan novum dalam peninjauan kembali perkara perdata? Metode penelitian yang digunakan dalam tulisan ini adalah metode penelitian yuridis normatif atau metode penelitian kepustakaan. Hasil penelitian menunjukkan bahwa jika dikaji dari alasan pengajuan peninjauan kembali yang diatur dalam Undang-Undang Nomor 14 Tahun 1985 tentang Mahkamah Agung, suatu putusan pengadilan dapat dijadikan alasan dalam permohonan peninjauan kembali, apabila ada pertentangan antara putusan yang satu dengan yang lain. Pertentangan itu harus antara putusan oleh peradilan yang sama atau sama tingkatan. Pengajuan putusan peninjauan kembali perkara pidana menjadi novum dalam peninjauan kembali perkara perdata atau sebaliknya, tidak dapat dibenarkan.Kata kunci: peninjauan kembali, pidana, perdata, novum. ABSTRACT Law Number 15 of 2001 concerning Trademark stipulates that resolution of disputes or violations of brands can be taken through two alternative ways, namely filing a lawsuit to the Commercial Court (civil) and secondly filing a complaint with the investigator for a criminal settlement. These two solutions were taken at the same time by both parties, GG against GB. This case was then up to the extraordinary request for review. In the review of civil cases, GG filed a decision on a criminal case review as novum. Based on this, the problems outlined in this analysis is whether the decision of a criminal case review can be made novum in reviewing a civil case. The method used is a normative juridical research method or literature research method. As stipulated in Law Number 14 of 1985 concerning the Supreme Court, pertaining to the reasoning of filing an extraordinary request for case review, the research result shows that a court decision can be used as an excuse to file a case review, provided that there is conflict between one decision and another. Filing a criminal case review decision as novum in civil case review or vice versa cannot be justified. Keywords: case review, criminal, civil, novum.
PENGARUH KONSENTRASI DAN SUHU LARUTAN GULA PADA PROSES DEHIDRASI OSMOTIK BUAH NAGA (Hylocereus sp.)
Authors: Spetriani Spetriani 
Published: May 2019

ABSTRACTOsmotic dehydration is a water removing process that carried out on a object by immersing the object into an hyper-tonic (osmotic) solution. The process is commonly applied on pre-drying of fruit. The purpose of this research is to investigate the effect of concentration and temperature of osmotic solution on moisture content change, total dissolved solids change and to determine of water diffusion coefficient and solid diffusion coefficient during the process of osmotic dehydration of dragon fruit. Factorial design was used with 2 factors, each consisting of 3 levels with 3 replication. The treatment on this research are : solution consentration of 30 °Brix, 50 °Brix, and 70 °Brix and solution temperature of 30 °C, 40 °C, and 50 °C were applied to this research. The osmotic dehydration process lasts for 8 hours. Initial moisture content of dragon fruit used for the research between 511.17-665.97 (% db). Moisture and solid diffusivities were in the range of 2.810 x 10-8 m²/s - 7.003 x 10-8 m²/s and 0.973 x 10-8 m²/s until 4.734 x 10-8 m²/s. The activation energy for diffusion of water to the concentration of 30 °Brix, 50 °Brix, and 70 °Brix respectively is 9.963 kJ/mol, 3.249 kJ/mol, and 5.372 kJ/mol. While the activation energy for diffusion of solids is 24.946 kJ/mol, 8.908 kJ/mol, and 27.343 kJ/mol. Keywords: dragon fruit, moisture diffusivity, osmotic dehydration, solid diffusivity
ABSTRAK
Dehidrasi osmotik adalah suatu proses pengeluaran air yang dilakukan terhadap suatu bahan dengan cara merendam bahan tersebut ke dalam suatu larutan hipertonik. Proses ini pada umumnya diaplikasikan untuk pra-pengeringan buah-buahan. Tujuan penelitian ini adalah untuk mengkaji pengaruh perlakuan konsentrasi dan suhu terhadap perubahan kadar air, perubahan total padatan terlarut dan untuk menentukan nilai koefisien difusi air dan difusi padatan selama proses dehidrasi osmotik pada buah naga. Digunakan rancangan faktorial dengan 2 faktor yang masing-masing terdiri atas 3 taraf dengan 3 kali ulangan. Perlakuan yang digunakan pada penelitian ini adalah variasi konsentrasi larutan 30 °Brix, 50 °Brix, dan 70 °Brix dan suhu larutan 30 °C, 40 °C, dan 50 °C. Proses dehidrasi osmotik berlangsung selama 8 jam. Kadar air awal buah naga yang digunakan untuk penelitian berkisar antara 511,17-665,97 (%db). Nilai difusivitas air antara 2,810 x 10-8 m²/s – 7,003 x 10-8 m²/s dan difusivitas padatan antara 0,973 x 10-8 m²/s - 4,734 x 10-8 m²/s. Energi aktivasi untuk difusi air untuk konsentrasi 30 °Brix, 50 °Brix, dan 70 °Brix secara berurutan adalah 9,963 kJ/mol, 3,249 kJ/mol, dan 5,372 kJ/mol. Energi aktivasi untuk difusi padatan adalah 24,946 kJ/mol, 8,908 kJ/mol, dan 27,343 kJ/mol.
Kata kunci: buah naga, dehidrasi osmotik, difusivitas air, difusivitas padatan
PEMBUATAN MEMBRAN SELULOSA ASETAT DARI TANDAN KOSONG KELAPA SAWIT
Authors: Putra Alfian 
Published: May 2019

Membran selulosa asetat dapat dibuat dari Tandan Kosong Kelapa Sawit (TKKS), dengan mengkonversi TKKS menjadi pulp, dilanjutkan dengan pembentukan selulosa asetat yang akan dibuat menjadi membran. Proses pembuatan selulosa asetat dari pulp TKKS adalah dengan melakukan reaksi asetilasi selulosa, yaitu menggunakan asetat anhidrat dan asetat glasial. Metode yang digunakan adalah dengan cara inversi fasa. Kondisi optimum pada proses asetilasi didapat pada suhu 1000C dengan kadar selulosa asetat 61,4% dan kadar asetil 36,39%. Temperatur dan waktu pengadukan berpengaruh terhadap kekuatan tarik dan elongasi membran. Kekuatan tarik dan elongasi membran terbaik didapat pada kadar asetil 36,32% dengan kekuatan tarik 4,61 kgf/cm2 dan elongasi 5,23%. Kata Kunci: Pulp, asetil, inversi fasa, membran selulosa asetat.
Characteristics of the level of somatic health and biological age of persons with neuro-stressful professional activity
Authors: Bush Michail P. , Diakovich Marina P. 
Published: May 2019

Introduction.Unfavorable tendencies in the health of the working population, especially those with high neuro-emotional stress in professional activities, the scarcity of information about the impact of professional factors on the health and performance of police officers, which is characterized by nervous and hard work, determine the relevance of this study.The aim of the studyis to study the biological age with an assessment of the rate of aging of individual body systems and the level of somatic health of police officers.Materials and methods.We examined 110 men — police officers. Biological age was determined by an automated expert system of diagnostics of aging by the method of A.A. Podkolzin, V.N. Crutko. To quantify the level of somatic health the method of G.L. Apanasenko was used. We used clinical, physiological and computational methods to study the state of the cardiovascular and respiratory systems, static balancing, interviewing methods and mathematical statistics.Results.The accelerated rate of aging was revealed in 65.4% of the examined patients. Accelerated aging of the neuropsychic, respiratory and cardiovascular systems was the most common (97.3%, 94.6% and 75.5%, respectively). A decrease in functional activity of blood circulation was revealed in 70.9%. The coefficients of endurance of cardiac activity and efficiency of blood circulation exceeded the norm, which indicates a possible weakening of the activity and the state of fatigue of the cardiovascular system, myocardial weakness. The ratio of pulse wave velocity in the vessels of muscular and elastic types below the norm was determined in 40.9% of the surveyed, which may indicate the presence of transitional and late-stage hypertension, 62.2% of such persons have an accelerated type of aging of the cardiovascular system. The proportion of persons with accelerated type of aging of the respiratory system significantly (p<0.05) exceeded the proportion of persons with normal and delayed type of aging. The proportion of persons with an accelerated rate of aging was significantly higher in persons with a duration of static balancing below the standard (79.1% [71.5–86.7] versus 20.9% [13.3–28.5], p=0.009).Conclusions.Accelerated rates of aging of cardiovascular, respiratory and neuropsychic systems, low functionality of the body can be regarded as a manifestation of occupational stress. The discrepancy between the subjective assessment of their health and objective indicators of the rate of aging, the level of somatic health can be caused by the socio-psychological characteristics of the service and the tightening of medical requirements for police officers.