bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Call to Decolonise: Social Work’s Challenge for Working with Indigenous Peoples
Authors: Choate Peter W 
Published: February 2019

AbstractUsing Canada as an example, social work must not only address its historical and current role in the colonisation and assimilation efforts aimed at Indigenous people, but also deconstruct its practices. Social work theory, methodology and practice parameters have been built on Eurocentric definitions and understandings. Indigenous peoples do not identify with these constructs but find themselves assessed and case managed based upon them. This extends colonialism and runs counter to a core principle of the profession, that being social justice. Canada is presently calling social work to participate in a reconciliation effort, although that assumes that there was a mutually beneficial relationship to restore. Some argue against that but there is a strong consensus that social work should carry its share of the burden in colonialism and self-reflect while also reaching out to build a different type of relationship with Indigenous peoples. This article reports on three projects that consider Indigenous knowledge and application to social work. Child protection is seen as a major focal point of change, as Indigenous children are significantly over-represented in the children in care population. Looking at this area of practice will help to illustrate the long roots of the colonial practices but also how current practice remains problematic.
Identity-Based Signature Schemes for Multivariate Public Key Cryptosystems
Authors: Chen Jiahui , Ling Jie , Ning Jianting , Ding Jintai 
Published: February 2019

AbstractIn this paper, we proposed an idea to construct a general multivariate public key cryptographic (MPKC) scheme based on a user’s identity. In our construction, each user is distributed a unique identity by the key distribution center (KDC) and we use this key to generate user’s private keys. Thereafter, we use these private keys to produce the corresponding public key. This method can make key generating process easier so that the public key will reduce from dozens of Kilobyte to several bits. We then use our general scheme to construct practical identity-based signature schemes named ID-UOV and ID-Rainbow based on two well-known and promising MPKC signature schemes, respectively. Finally, we present the security analysis and give experiments for all of our proposed schemes and the baseline schemes. Comparison shows that our schemes are both efficient and practical.
Successful renal denervation decreases the platelet activation status in hypertensive patients
Authors: Zaldivia Maria T K , Hering Dagmara , Marusic Petra , Sata Yusuke , Lee Rebecca , Esler Murray D , Htun Nay M , Duval Jacqueline , Hammond Louise , Flierl Ulrike , Wang Xiaowei , Drummond Grant R , Walton Antony , Gardiner Elizabeth E , Andrews Robert K , Schlaich Markus P , Peter Karlheinz 
Published: February 2019

AbstractAimsTo determine whether renal denervation (RDN) in hypertensive patients affects the platelet activation status.Methods and resultsWe investigated the effect of RDN on the platelet activation status in 41 hypertensive patients undergoing RDN. Ambulatory blood pressure (BP), plasma sympathetic neurotransmitter Neuropeptide Y, and platelet activation markers were measured at baseline, at 3 months, and 6 months after RDN. RDN significantly decreased BP at 3 months (150.6 ± 11.3/80.9 ± 11.4 mmHg to 144.7 ± 12.0/77.1 ± 11.1 mmHg; P &lt; 0.01) and at 6 months (144.3 ± 13.8/78.3 ± 11.1 mmHg; P &lt; 0.01). Plasma levels of the sympathetic neurotransmitter Neuropeptide Y, an indicator of sympathetic nerve activity, were significantly decreased at 3 months (0.29 ± 0.11 ng/mL to 0.23 ± 0.11 ng/mL; P &lt; 0.0001) and at 6 months (0.22 ± 0.12 ng/mL; P &lt; 0.001) after RDN. This was associated with a reduction in platelet membrane P-selectin expression (3 months, P &lt; 0.05; 6 months, P &lt; 0.05), soluble P-selectin (6 months, P &lt; 0.05), circulating numbers of platelet-derived extracellular vesicles (EVs) (3 months, P &lt; 0.001; 6 months, P &lt; 0.01), and phosphatidylserine expressing EVs (3 months, P &lt; 0.001; 6 months, P &lt; 0.0001), indicative of a reduction in platelet activation status and procoagulant activity. Only patients who responded to RDN with a BP reduction showed inhibition of P-selectin expression at 3 months (P &lt; 0.05) and 6 months (P &lt; 0.05) as well as reduction of glycoprotein IIb/IIIa activation at 3 months (P &lt; 0.05). Notably, 13 patients who took aspirin did not show significant reduction in platelet P-selectin expression following RDN.ConclusionOur results imply a connection between the sympathetic nervous system and the platelet activation status and provide a potential mechanistic explanation by which RDN can have favourable effects towards reducing cardiovascular complications.
Rapid Changes in Laboratory Parameters and Early Response to Adalimumab: A Pooled Analysis From Patients With Ulcerative Colitis in Two Clinical Trials
Authors: Hanauer Stephen , Sandborn William J , Colombel Jean-Frederic , Vermeire Severine , Petersson Joel , Kligys Kristina , Zhou Qian , Lazar Andreas , Reinisch Walter 
Published: February 2019

Abstract

Background and Aims
The efficacy and safety of adalimumab for induction and maintenance of clinical remission in patients with moderately to severely active ulcerative colitis were demonstrated in the ULTRA 1 and 2 clinical trials. This post-hoc, pooled analysis evaluated early changes in laboratory parameters, Mayo subscores, mucosal healing, and health-related quality of life.

Methods
Mean changes in laboratory parameters including albumin, high-sensitivity C-reactive protein, total protein, haematocrit, haemoglobin, red blood cell and platelet counts, Inflammatory Bowel Disease Questionnaire, and Short Form 36 Health Survey were evaluated from baseline to Weeks 4 and 8. Mean changes in Mayo subscores of rectal bleeding and stool frequency were evaluated from baseline to Weeks 2, 4, 6, and 8. Mucosal healing was assessed with endoscopy at baseline and Week 8. Categorical variables were evaluated with the Cochran-Mantel-Haenszel test; continuous variables were evaluated with analysis of covariance and considered significant if p <0.05.

Results
Treatment with adalimumab significantly improved laboratory and quality-of-life measures at Weeks 4 and 8 compared with placebo [p <0.05 and p <0.001]. Mean reductions from baseline in rectal bleeding and stool frequency were significantly larger in patients receiving adalimumab compared with placebo at Week 2 and sustained through Week 8 [p <0.01]. Normal mucosa at Week 8 was achieved by 13% of patients receiving adalimumab compared with 6% of those receiving placebo [p <0.001].

Conclusions
Adalimumab resulted in rapid improvements in laboratory markers and early reductions in rectal bleeding and stool frequency. Early improvement in quality-of-life scores correlated with the clinical and laboratory findings.
Effects of a randomized, culturally adapted, lifestyle intervention on mental health among Middle-Eastern immigrants
Authors: Siddiqui Faiza , Lindblad Ulf , Nilsson Peter M , Bennet Louise 
Published: February 2019

Abstract

Background
Middle-Eastern immigrants in Sweden are at increased risk for type 2 diabetes (T2D) and poor mental health. Physical activity not only prevents/delays onset of T2D but also shows favorable effects on mental health. However, the effects of a culturally adapted lifestyle intervention on mental health among Middle-Eastern immigrants have not been explored before. We aimed to study the effects of a randomized controlled, culturally adapted lifestyle intervention on anxiety and depression levels in diabetes-prone Iraqi immigrants.

Methods
Participants (n = 96) were randomized to intervention group, IG (n = 50) or control group, CG (n = 46). The IG received seven group sessions addressing lifestyle change and the CG received treatment as usual. Montgomery–Åsberg Depression Rating Scale (MADRS-S) and Hospital Anxiety and Depression Scale (HADS) assessed mental health at start, mid (2 months) and end of the study (4 months). Proportional odds ratio (OR) model was used to study the effect of the intervention.

Results
The odds of scoring lower on MADRS-S and HADS depression scale at visit 3 vs. baseline were higher in the IG compared to the CG (MADRS-S OR 5.9, 95% CI: 1.6–22.5; HADS OR 4.4, 95% CI: 0.9–20.3). The findings persisted after adjustment for age, sex, body mass index, time since migration, sedentary lifestyle and language spoken at home. Group differences were non-significant at visit 2 vs. baseline.

Conclusion
A culturally adapted lifestyle intervention addressing T2D prevention in Middle-Eastern immigrants has favorable effects on mental health. The effect was more pronounced at the 4 months than at 2 months follow-up, indicating beneficial effect of longer study duration.

Trial registration
www.clinicaltrials.gov NCT01420198.
The Impact of Spouse’s Illness on Depressive Symptoms: The Roles of Spousal Caregiving and Marital Satisfaction
Authors: Min Joohong , Yorgason Jeremy B , Fast Janet , Chudyk Anna 
Published: February 2019

Abstract

Objectives
To examine (a) the relationship between own depressive symptoms and spouses’ health condition changes among mid- and later-life couples and (b) the roles of marital relationship quality and spousal caregiving in this relationship.

Method
Fixed-effect analyses were conducted using data from 3,055 couples aged 45 and older from Waves 1 (2006) to 4 (2012) of the Korean Longitudinal Study on Ageing.

Results
Spousal stroke was linked with higher depression symptoms. Spouses’ onset of cancer was related to an increase in depressive symptoms for wives, but not for husbands. Spousal caregiving and marital satisfaction were significant moderators: Wives caring for spouses with cancer reported more depressive symptoms than those not providing care; husbands caring for spouses with lung disease reported more depressive symptoms than those not providing care. The associations between wives’ heart disease, husbands’ cancer diagnosis, and depressive symptoms were weaker for couples with higher marital satisfaction.

Discussion
The findings suggest variations across health condition types and gender. Relationship quality and caregiving are important contexts moderating the negative impact of spousal chronic illness on depression. Health care providers should be aware that spouses’ health statuses are connected and that type of illness may affect the care context.
Towards coherent GES assessments at sub-regional level: signs of fisheries expansion processes in the Bay of Biscay using an OSPAR food web indicator, the mean trophic level
Authors: Arroyo Nina-Larissa , Safi Georges , Vouriot Pauline , López-López Lucía , Niquil Nathalie , Le Loc’h Francois , Hattab Tarek , Preciado Izaskun 
Published: February 2019

Abstract
Using the Bay of Biscay (BoB) as a case study, we conducted a transnational assessment of the mean trophic level (MTL, Ospar FW4) indicator at sub-regional level, over the last three decades. Our results confirm the apparent recovery of BoB’s bentho-demersal system, as shown by trends in the MTL indicator based on survey data. However, they also point at a concomitant “fishing through” process where the apparent stability revealed by the MTL indicator based on landed catch data may be masking the expansion of demersal fisheries to deeper waters, and an over-exploitation of resources (particularly abundant pelagic species). Moreover, they show how the combined examination of independent surveys and fishery landings allows the identification of ecological trends in ecosystem studies. In addition, our results confirm that analysing MTL at various threshold levels helps discerning the causality of trends in this indicator, especially if analyses for pelagic and demersal species are run independently. Further studies, at smaller (i.e. local) spatial scales, need to be conducted to ascertain our results and suggest appropriate management strategies aimed at regulating fisheries expansions in the area.
Rediscovering the tidal tails of NGC 288 with Gaia DR2
Authors: Kaderali Shaziana , Hunt Jason A S , Webb Jeremy J , Price-Jones Natalie , Carlberg Raymond 
Published: February 2019

ABSTRACT
NGC 288 is a Galactic globular cluster having observed extra-tidal structure, without confirmed tidal tails. Gaia DR2 provides photometric and astrometric data for many of the stars in NGC 288 and its extra-tidal structure. To compare with the Gaia data, we simulate a N-body model of a star cluster with the same orbit as NGC 288 in a Milky Way potential. The simulation shows that the cluster forms tidal tails that are compressed along the cluster’s orbit when it is at apocentre and are expected to be a diffuse bipolar structure. In this letter, we present a comparison between the simulation and observations from Gaia DR2. We find that both the simulation and the observations share comparable trends in the position on the sky and proper motions of the extra-tidal stars, supporting the presence of tidal tails around NGC 288.
Structural basis of ubiquitin recognition by the winged-helix domain of Cockayne syndrome group B protein
Authors: Takahashi Diane T , Sato Yusuke , Yamagata Atsushi , Goto-Ito Sakurako , Saijo Masafumi , Fukai Shuya 
Published: February 2019

Abstract
Cockayne syndrome group B (CSB, also known as ERCC6) protein is involved in many DNA repair processes and essential for transcription-coupled repair (TCR). The central region of CSB has the helicase motif, whereas the C-terminal region contains important regulatory elements for repair of UV- and oxidative stress-induced damages and double-strand breaks (DSBs). A previous study suggested that a small part (∼30 residues) within this region was responsible for binding to ubiquitin (Ub). Here, we show that the Ub-binding of CSB requires a larger part of CSB, which was previously identified as a winged-helix domain (WHD) and is involved in the recruitment of CSB to DSBs. We also present the crystal structure of CSB WHD in complex with Ub. CSB WHD folds as a single globular domain, defining a class of Ub-binding domains (UBDs) different from 23 UBD classes identified so far. The second α-helix and C-terminal extremity of CSB WHD interact with Ub. Together with structure-guided mutational analysis, we identified the residues critical for the binding to Ub. CSB mutants defective in the Ub binding reduced repair of UV-induced damage. This study supports the notion that DSB repair and TCR may be associated with the Ub-binding of CSB.
An Open-Label, 52-Week, Phase III Trial of Duloxetine in Japanese Patients with Chronic Low Back Pain
Authors: Konno Shin-ichi , Alev Levent , Oda Natsuko , Ochiai Toshimitsu , Enomoto Hiroyuki 
Published: February 2019

Abstract

Objective
To evaluate the safety and efficacy of duloxetine treatment for 52 weeks.

Design
Multicenter, open-label, phase III clinical study.

Setting
Forty-one medical institutions in Japan.

Subjects
Japanese patients with chronic low back pain (CLBP).

Methods
Duloxetine 60 mg once-daily was administered for 52 weeks. Safety was evaluated based on adverse events (AEs), vital signs, laboratory test values, electrocardiogram, Columbia-Suicide Severity Rating Scale, and occurrence of falls. The efficacy outcome measures were the Brief Pain Inventory (BPI; average pain, worst pain, least pain, and pain right now), BPI Interference, Patient’s Global Impression of Improvement (PGI-I), Clinical Global Impressions of Severity (CGI-S), Roland-Morris Disability Questionnaire–24 (RDQ-24), 36-Item Short-Form Health Survey (SF-36), and European Quality of Life-5 Dimensions Questionnaire (EQ-5D).

Results
In total, 151 patients (83 who completed a 14-week placebo-controlled superiority trial and 68 newly registered patients) were enrolled. The incidence rates of AEs and adverse drug reactions (ADRs) were 86.1% and 50.3%, respectively. ADRs with an incidence of ≥5% were somnolence, constipation, nausea, and dry mouth. Treatment discontinuation for AEs occurred in 16 patients. A significant reduction in the BPI average pain score (mean ± SD) was observed at all assessment time points from week 2 (−1.02 ± 1.37) to week 50 (−2.26 ± 1.63), compared with baseline. BPI pain severity (worst pain, least pain, and pain right now), BPI Interference, PGI-I, CGI-S, RDQ-24, SF-36, and EQ-5D showed significant improvement.

Conclusion
Japanese patients with CLBP had significant pain reduction over 52 weeks without new safety concerns.
Where Have the Respondents Gone? Perhaps We Ate Them All
Authors: Leeper Thomas J 
Published: February 2019

AbstractRising rates of nonresponse are one of the most-debated issues in contemporary survey research. While early survey research regularly achieved response rates close to 100 percent, contemporary telephone interviewing methods in the United States regularly obtain response rates below 10 percent, due to a mix of noncontact and refusals. Existing research has examined a number of factors that explain variation in response rates, yet almost all such work considers survey response as an isolated, independent event. This note aims to stimulate debate by suggesting that a paradigm shift in theorizing nonresponse is needed. I diagnose the problem of nonresponse not only as an individual-level, survey-specific phenomenon, but as something larger and more collective: namely, as a common pool resource (CPR) problem. Because researchers acting independently might each seek to maximize their response rate and achieve intended sample sizes, the common pool resource of human respondents can be prone to overextraction. In addition to thinking about “benefit-cost” explanations for why respondents might respond to a specific survey, considering responses as a shared resource focuses attention on cross-level theory on how the survey field might collectively govern responses from human populations. Rather than testing CPR theory directly, I instead describe why thinking of nonresponse as a CPR problem may be useful, use the United States as a case study to demonstrate the possible scale of response extraction, and leverage findings from CPR studies to suggest directions for future research into nonresponse.
Immediate Reconstruction of Complex Spinal Wounds Is Associated with Increased Hardware Retention and Fewer Wound-related Complications: A Systematic Review and Meta-analysis
Authors: Mericli Alexander F. , Largo Rene D. , Garvey Patrick B. , Rhines Laurence , Bird Justin , Liu Jun , Baumann Donald , Butler Charles E. 
Published: February 2019

Background:
Patients undergoing surgeries involving extensive posterior spine instrumentation and fusion often have multiple risk factors for wound healing complications. We performed a systematic review and meta-analysis of the available evidence on immediate (proactive/prophylactic) and delayed (reactive) spinal wound reconstruction. We hypothesized that immediate soft-tissue reconstruction of extensive spinal wounds would be associated with fewer postoperative surgicalsite complications than delayed reconstruction.

Methods:
In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a PubMed database search was performed to identify English-language, human-subject literature published between 2003 and 2018. Data were summarized, and the pooled prevalence of various wound complications was calculated, weighted by study size, using the generic inverse variance method. A subgroup analysis of all studies with a comparison group (Oxford Centre for Evidence-based Medicine level 3 or better) was performed, and Forest plots were created.

Results:
The database search yielded 16 articles including 828 patients; 428 (51.7%) received an immediate spinal wound reconstruction and 400 (48.3%) had a delayed reconstruction. Spinal neoplasm was the most common index diagnosis. Paraspinous muscle flap reconstruction was performed in the majority of cases. Pooled analysis of all studies revealed immediate reconstruction to be associated with decreased rates of overall wound complications (28.5% versus 18.8%), hardware loss (10.7% versus 1.8%), and wound infections (10.7% versus 7.6%) compared with delayed reconstruction.

Conclusions:
Immediate soft-tissue reconstruction of high-risk spinal wounds is associated with fewer wound healing complications and increased hardware retention.
Gender-Specific Risk Factor Profiles for Patellofemoral Pain
Authors: Boling Michelle C. , Nguyen Anh-Dung , Padua Darin A. , Cameron Kenneth L. , Beutler Anthony , Marshall Stephen W. 
Published: February 2019

Objective:
To determine the association between selected biomechanical variables and risk of patellofemoral pain (PFP) in males and females.

Design:
Prospective cohort.

Setting:
US Service Academies.

Participants:
Four thousand five hundred forty-three cadets (1727 females and 2816 males).

Assessment of risk factors:
Three-dimensional biomechanics during a jump-landing task, lower-extremity strength, Q-angle, and navicular drop.

Main outcome measures:
Cadets were monitored for diagnosis of PFP during their enrollment in a service academy. Three-dimensional hip and knee kinematic data were determined at initial contact (IC) and at 50% of the stance phase of the jump-landing task. Logistic regression analyses were performed for each risk factor variable in males and females (P < 0.05).

Results:
Less than 10 degrees of hip abduction at IC [odds ratio (OR) = 1.86, P = 0.03] and greater than 10 degrees of knee internal rotation at 50% of the stance phase (OR = 1.71, P = 0.02) increased the risk of PFP in females. Greater than 20 degrees of knee flexion at IC (OR = 0.47, P < 0.01) and between 0 and 5 degrees of hip external rotation at 50% of the stance phase (OR = 0.52, P = 0.04) decreased the risk of PFP in males. No other variables were associated with risk of developing PFP (P > 0.05).

Conclusions:
The results suggest males and females have differing kinematic risk factor profiles for the development of PFP.

Clinical relevance:
To most effectively reduce the risk of developing PFP, the risk factor variables specific to males (decreased knee flexion and increased hip external rotation) and females (decreased hip abduction and increased knee internal rotation) should be addressed in injury prevention programs.