bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the vulnerability of Australia’s urban forests to climate extremes
Authors: Esperon‐Rodriguez Manuel , Power Sally A. , Tjoelker Mark G. , Beaumont Linda J. , Burley Hugh , Caballero‐Rodriguez Dayenari , Rymer Paul D. 
Published: August 2019

Societal Impact StatementUrban forests are recognized for the multiple benefits they provide to city‐dwellers. However, climate change will affect tree species survival and persistence in urban ecosystems. Tree failures will cause economic losses and jeopardize the delivery of societal benefits. The impacts of climate change will depend on the species’ resilience and adaptive capacity, as well as management actions which may ameliorate some of the negative impacts. Here, we assessed the potential vulnerability of Australia's urban forests to climate extremes. Our results can be used for future urban planning aiming to incorporate species that are well‐adapted to the hotter, drier climates expected with climate change.SummaryUrban forests (UFs) are recognized for the multiple benefits they provide to city‐dwellers. However, global climate change—particularly predicted increases in the frequency and intensity of heatwaves and drought—will affect tree species’ performance and survival in urban ecosystems.Here, we assessed species composition and potential vulnerability of UFs in 22 Australian significant urban areas (SUAs) to heat and/or moisture stress. We quantified species’ realized climatic niches across their known distribution, and assessed the extent to which baseline climate in the SUAs where a particular species is planted fell within its niche. We used three environmental variables to group species based on their potential climate vulnerability.UFs varied in species composition and climate vulnerability across the continent. In general, neither climate similarity nor geographical proximity were good predictors of species composition among UFs. Of 1,342 tree species assessed (68.4% natives), 53% were considered potentially vulnerable to heat and/or moisture stress in at least one city where they are currently planted.Our results highlight the climate vulnerability of current plantings across Australian SUAs and can be used to direct future species selection that considers the species’ climate of origin and climatic niche. UF planning can incorporate species from SUAs with similar climates and with low vulnerability to contemporary, as well as future climate conditions. Species with high climate vulnerability, in contrast, may require more intensive management to avoid failure under future hotter, drier climate conditions.
Multidisciplinary Role of Mesoporous Silica Nanoparticles in Brain Regeneration and Cancers: From Crossing the Blood–Brain Barrier to Treatment
Authors: Mendiratta Shruti , Hussein Menna , Nasser Hebatallah A. , Ali Ahmed Atef Ahmed 
Published: August 2019

AbstractMesoporous silica nanoparticles (MSNs) have gained wide attention for their role in biomedicine and as drug delivery vehicles. Their structural tunability, high surface area, and easy functionalization impart significant advantages over conventional materials. In this Review, recent advances in the synthesis, drug delivery, and therapeutic roles of MSNs in the treatment of various neurodegenerative and neuroinflammatory diseases are presented. The intention is to understand how MSN formulations that are capable of encapsulating drug molecules can enhance drug delivery by overcoming the blood–brain barrier (BBB) mediated by specific transport processes. The composition and characteristics of the BBB, and how alterations are observed in neurodegenerative diseases including Alzheimer's, epilepsy, and intracerebral hemorrhage are reviewed. Finally, the factors affecting efficient delivery of MSNs into the brain are summarized, and their most promising functional outcomes are discussed.
Molecular networking as a dereplication strategy for monitoring metabolites of natural product treated cancer cells
Authors: Gao Yi‐Ling , Wang Ying‐Jing , Chung Hsin‐Hsiang , Chen Ko‐Chien , Shen Tang‐Long , Hsu Cheng‐Chih 
Published: August 2019

RationaleNatural products have been great sources for drug discovery. However, the structures of natural products are diverse and difficult to elucidate. Cordyceps militaris is a parasitic fungus which usually grows on host insects. The metabolites of C. militaris have been reported to act as chemotherapeutic agents. In this study, we aimed for the structural elucidation of specialized metabolites derived from C. militaris, and the metabolic impact in leukemia cells.MethodsWe describe a liquid chromatography data‐dependent mass spectrometric platform combining tandem mass analysis and molecular networking. Leukemia cells treated with C. militaris extract and control groups were visualized in terms of their metabolic profiles using Global Natural Product Social (GNPS) molecular networking. By this method, we were able to elucidate the structures of metabolites from medicinal fungus extracts and cancer cells and then to recognize their changes in a semi‐quantitative manner.ResultsUsing C. militaris and leukemia cells as examples, we found that approximately 100 new ion species were present in the treated leukemia cells, suggesting a highly altered metabolic profile. Specifically, based on the tandem mass spectral similarity, we proposed that cordycepin, a key fungus‐derived therapeutic agent known for its antitumor activity, was transformed into its methylthio form in leukemia cells.ConclusionsThe platform described provides an ability to investigate complex molecular interactions of natural products in mammalian cells. By incorporating tandem mass spectrometry and molecular networking, we were able to reveal the chemical modification of crude bioactive compounds, for example potential bioactive compounds which might be modified from cordycepin. We envision that such a mass spectrometry (MS)‐based workflow, combined with other metabolomics platforms, would enable much wider applicability to cell biology and be of great potential to pharmacological study as well as drug discovery.
Seroprevalence and characterization of Brucella species in cattle slaughtered at Gauteng abattoirs, South Africa
Authors: Kolo Francis B. , Adesiyun Abiodun A. , Fasina Folorunso O. , Katsande Charles T. , Dogonyaro Banenat B. , Potts Andrew , Matle Itumeleng , Gelaw Awoke K. , van Heerden Henriette 
Published: August 2019

AbstractBackgroundBrucellosis is an infectious and contagious zoonotic bacterial disease of both humans and animals. In developing countries where brucellosis is endemic, baseline data on the prevalence of brucellosis, using abattoir facilities, is important.ObjectivesThe aim of this study was to determine the seroprevalence of antibodies against Brucella in slaughter cattle at Gauteng province, South Africa and to characterize isolates of Brucella spp.MethodsIn this cross‐sectional study, un‐clotted blood samples with corresponding organ tissue samples were collected from slaughtered cattle. Serological [Rose Bengal test (RBT), complement fixation test (CFT) and indirect ELISA (iELISA)], molecular (PCR) and bacteriological methods were used to detect Brucella antibodies and Brucella spp. from 200 slaughtered cattle in 14 abattoirs.ResultsThe RBT revealed a seroprevalence of brucellosis as 11.0% (22 of 200) and iELISA confirmed 5.5% (11 of 200). The estimated seroprevalence from RBT and iELISA was 5.5% while RBT and CFT was 2.0% (4 of 200). Brucella melitensis (n = 6) and B. abortus (n = 5) were isolated from 11 cattle tissues (5.5%) as confirmed to species level with AMOS PCR and differentiated from vaccine strains with Bruce‐ladder PCR. Seven of the 11 isolates originated from seropositive cattle of which five were biotyped as B. abortus bv 1 (n = 2) and B. melitensis bv 2 (n = 1) and B. melitensis bv 3 (n = 2).ConclusionsThis is the first documentation of B. melitensis in cattle in South Africa. The zoonotic risk of brucellosis posed by Brucella‐infected slaughter cattle to abattoir workers and consumers of improperly cooked beef cannot be ignored.
Do Ice Packs Reduce Postoperative Midline Incision Pain, NSAID or Narcotic Use?
Authors: Ravindhran Bharadhwaj , Rajan Sendhil , Balachandran Gayatri , Mohan L. N. 
Published: August 2019

AbstractBackgroundAdequate postoperative analgesia, especially after major abdominal surgery is important for recovery, early mobility, and patient satisfaction. We aimed to study the effects of cryotherapy via an ice pack in the immediate postoperative period, for patients undergoing major abdominal operations.MethodsThis prospective study was conducted at our tertiary care referral center in a low–middle‐income country setting. The preoperative patient characteristics, intra‐operative variables, and postoperative outcomes were compared between two sets of patients. Cryotherapy was delivered via frozen gel packs for 24 h immediately following laparotomy. Pain relief was assessed with visual analog pain scores (VAS). Comparisons between groups were measured by Chi‐square test, Fischer's exact test, or Mann–Whitney U test as appropriate.ResultsSixty‐eight patients were included in the study: 33 in the cryotherapy group and 35 in the non‐cryotherapy group. Mean postoperative pain scores (VAS) were significantly lower in the cryotherapy group versus the control group (3.97 ± 0.6 vs. 4.9 ± 0.7 on postoperative day (POD) 1; p <  0.001, and 3 ± 0.5 vs. 09 ± 0.8 on POD2; p < 0.001). The median narcotic use in morphine equivalents was lesser in the cryotherapy group from POD 1–3 (66 (IQR‐16) vs. 89 (IQR‐17); p = 0.001). No significant difference was seen in the NSAID use between the groups. The cryotherapy group was also found to have a lesser incidence of surgical site infection (p = 0.03) and better lung function based on incentive spirometry (p = 0.01) and demonstrated earlier functional recovery based on their ability to perform the sit‐to‐stand test (p = 0.001).ConclusionIce packs are a simple, cost‐effective adjuvant to standard postoperative pain management which reduce pain and narcotic use and promote early rehabilitation.
Integrating conventional management methods with biological control for enhanced Tamarix management
Authors: Murray Leeland , Schutte Brian J. , Sutherland Carol , Beck Leslie , Ganguli Amy , Lehnhoff Erik 
Published: August 2019

AbstractInvasive shrubs like Tamarix spp. are ecological and economic threats in the U.S. Southwest and West, as they displace native vegetation and require innovative management approaches. Tamarix control typically consists of chemical and mechanical removal, but these methods may have negative ecological and economic impacts. Tamarisk leaf beetles (Diorhabda spp.) released for biocontrol are becoming increasingly established within Western river systems and can provide additional control. Previous Diorhabda research studied integration of beetle herbivory with fire and with mechanical management methods and herbicide application (e.g., cut stump), but little research has been conducted on integration with mowing and foliar herbicide application, which cause minimal soil disturbance. At Caballo Reservoir in southern New Mexico, we addressed the question: “How does Tamarix respond to chemical and mechanical control when Diorhabda is well established at a site?” A field experiment was conducted by integrating mowing and foliar imazapyr herbicide at standard (3.6 g ae L−1 [0.75% v/v] and low (1.2 g ae L−1 [0.25% v/v]) rates with herbivory. Treatments were replicated five times at two sites—a dry site and a seasonally flooded site. Beetles and larvae were counted and green foliage was measured over 2 yr. Mowing and full herbicide rates reduced green foliage and limited regrowth compared with low herbicide rate and beetles alone. Integrating conventional management such as mowing and herbicide with biocontrol could improve Tamarix management by providing stresses in addition to herbivory alone.
Characterizing e-cigarette use in veteran smokers with mental health conditions
Authors: Wang John , Rogers Erin , Fu Steven , Gravely Amy , Noorbaloochi Siamak , Sherman Scott 
Published: August 2019

AbstractIntroductionThe use of electronic cigarettes (e-cigarettes) in smokers with mental health conditions (MHC) is not well understood.AimsThis study aims to compare e-cigarette users and non-users among veteran smokers with MHC to characterize differences in smoking behavior, motivation to quit, psychological distress, primary psychiatric diagnosis, and other factors.MethodsBaseline survey data were used from a randomized smoking cessation trial enrolling smokers with MHC from four Veterans Health Administration hospitals. Participants were categorized as current, former (having ever tried an e-cigarette), or never e-cigarette users. Pearson's χ2 and ANOVA Type-3 F-tests were used to test the bivariate associations between e-cigarette use and variables measured.ResultsAmong 1,836 participants, mean age was 58 years (STD ± 12.5), 87% were male, 15% were current e-cigarette users (n = 275), and 27% were former users (n = 503). Sixty-five percent of e-cigarette users reported ‘wanting to quit smoking’ as a primary reason. Mean readiness to quit smoking (1–10) was 7.2, 6.8, and 6.4 for current, former, and never e-cigarette users, respectively (P = 0.0002). Sixty-three percent of current and former users and 55% of never-users reported some mental distress on Kessler-6 scale (P = 0.0003, OR = 1.4, 95% CI 1.1–1.7). A primary psychiatric diagnosis of alcohol or substance use disorder was recorded for 50% of current or former users and 60% of never-users (P = 0.0003, OR = 0.69, 95% CI 0.56–0.84).ConclusionsE-cigarette users were more ready to quit and most often reported using e-cigarettes to assist with quitting. E-cigarette users had more psychological distress and were less likely to have substance use disorders as their primary psychiatric diagnosis.
Enhanced linguistic prosodic skills in musically trained individuals with Williams syndrome
Authors: MARTÍNEZ-CASTILLA PASTORA , CAMPOS RUTH , SOTILLO MARÍA 
Published: August 2019

abstractIndividuals with Williams syndrome (WS) present prosodic impairments. They are also interested in musical activities. In typical development, a body of research has shown that the linguistic prosodic skills of musically trained individuals are enhanced. However, it is not known whether, in WS, musical training is also associated with enhanced prosodic performance, a question this study sought to answer. We compared the performance on linguistic prosodic tasks among seven musically trained and fourteen musically untrained individuals with WS, and typically developing peers. Among those with WS, musically trained participants outperformed their musically untrained counterparts on the perception of acoustic parameters involved in prosody, the understanding of questioning and declarative intonation, and the comprehension of prefinal contrastive stress. The results suggest that musical training facilitates prosodic performance in WS. Our findings also suggest common processing mechanisms for acoustic parameters involved in both prosody and music, and that positive music-to-language transfer effects could take place in WS. We discuss the implications of these results for intervention purposes.
‘Useful’ and ‘Earning’ Citizens? Gender, state, and the market in post-colonial Delhi
Authors: DATTA ANJALI BHARDWAJ 
Published: August 2019

AbstractThe Indian state treated the partition of Punjab as a ‘national disaster’ and training for refugee women was deemed essential to restore the social landscape; yet the kind of help it offered to refugee women rested on its clear assumptions and biases about the kind of work that was appropriate for them: women were offered training in embroidery, stitching, tailoring, and weaving, as these are associated with feminine and household-based skills. This article will reveal that the state rehabilitation enterprise was primarily masculine in focus. The state treated women refugees as secondary earners and as guardians of hearth, kith, and kin; it did not see them playing a definitive role in nation-building in post-colonial India. In the absence of state supportive policies, refugee women were compelled to take up informal jobs like petty trading, domestic service, and labouring work. This article suggests that refugee women were handicapped in the labour market at their very point of entry. It traces the history of women's informalities in Delhi. In doing so, it investigates the feminization and commercialization of urban space in twentieth-century Delhi. It urges that women made space in more than one way: identifying fragmentary livelihoods, producing small-scale capitalism, and creating informal markets.
Cryopreservation of incomplete compacted morulae and preliminary biopsy of excluded fragments
Authors: Petrushko Maryna , Yurchuk Taisiia , Piniaiev Volodymyr , Buderatska Natalia 
Published: August 2019

SummaryThe complexity of predicting embryo development potential at the cleavage stages and the emergence of epigenetic risks during prolonged in vitro culture of pre-implantation embryos made it more advantageous to transfer embryos at the morula stage to the uterine cavity. The criteria for estimating embryos at this stage that allow prediction of cryopreservation outcomes have been poorly described. All day 4 embryos (n = 224) were graded 1, 2, 3, 4 or 5 according to blastomere compaction degree (BCD = 100, 75, 50, 25 or 0%, respectively) and the survival and blastocyst formation rate of these morulae were studied after cryopreservation. An inverse dependence was found between survival rate and BCD. Excluded fragments were characterized by low osmotic reaction during exposure to cryoprotective medium and, after freeze-thawing, they were destroyed. As damaged necrotic areas of the embryo can affect their further development rate we proposed blastomeres and biopsy fragments of incomplete compacted morula be removed before embryo cryopreservation. This step led to significant increase in the post-thawing survival rate up to 93.1 ± 4.1%, 75 ± 8.8% and blastocyst formation rate up to 85.2 ± 10.4%, 59.4 ± 5.2% in grade 2 and grade 3 embryos, respectively. There was no significant difference in grade 4 embryos. Therefore the removal of blastomeres and biopsy fragments in incomplete compacted morulae can improve cryopreservation outcomes of grade 2 and grade 3 embryos with BCD.
An international survey of the nutrition management of chylothorax: a time for change
Authors: Marino L. V. , Bell K. L. , Woodgate J. ,   British Dietetic Association Paediatric Cardiology Interest Group, Doolan A. 
Published: August 2019

AbstractIntroduction:Although chylothorax is an uncommon complication following paediatric cardiothoracic surgery, it has significant associated morbidities and increased in-hospital mortality, as well as results in higher costs. A lack of prospective evidence or consensus guidelines for management of chylothorax further hinders optimal management. The aim of this survey was to characterise variations in practice in the management of chylothorax and to identify areas for future research.Materials and methods:A descriptive, observational survey investigating conservative management practices of chylothorax was distributed internationally to health-care professionals in paediatric intensive care and cardiology units. The survey investigated five domains: the first providing general information about health-care professionals and four domains focusing on clinical practice including diet composition and duration.Results:In total, sixty-four health-care professionals completed the survey, representing 38 organisations from 16 countries. The respondents were dietitians (80%), physicians (19%), and nurses (1%). In Australia and New Zealand, management was most commonly directed by physicians’ preference (67%) as compared to unit protocols in Europe (67%), United States of America (67%), and Other regions (55%). Dietitians in Australia/New Zealand, United Kingdom, and Ireland followed the most restrictive diet therapy recommending &lt;5 g long chain triglyceride fat per day (p &lt; 0.00001). The duration of diet therapy significantly varied between regions: Australia/New Zealand: 4 weeks (36%) and 6 weeks (43%); Europe: 4 weeks (25%) and 6 weeks (57%); and North America: 4 weeks (18%) and 6 weeks (75%) (p &lt; 0.00001).Conclusions:This survey highlights international variations in practice in the management of chylothorax, particularly with respect to treatment duration and dietary fat restriction. Future research should include a multi-centre randomised controlled trial to inform evidence-based practice and reduce morbidity, particularly poor growth.
Domain bias in distinguishing Flemish and Dutch subtitles
Authors: van Halteren Hans 
Published: August 2019

AbstractThis paper describes experiments in which I tried to distinguish between Flemish and Netherlandic Dutch subtitles, as originally proposed in the VarDial 2018 Dutch–Flemish Subtitle task. However, rather than using all data as a monolithic block, I divided them into two non-overlapping domains and then investigated how the relation between training and test domains influences the recognition quality. I show that the best estimate of the level of recognizability of the language varieties is derived when training on one domain and testing on another. Apart from the quantitative results, I also present a qualitative analysis, by investigating in detail the most distinguishing features in the various scenarios. Here too, it is with the out-of-domain recognition that some genuine differences between Flemish and Netherlandic Dutch can be found.
Teaching Americans to be International Citizens: World Music and Dance on Television's Omnibus
Authors: NEKOLA ANNA E. 
Published: August 2019

AbstractIn the 1950s,Omnibus,a US television variety show sponsored by the Ford Foundation, provided US viewers with their first encounters with classical music and dance from Japan and India and folk traditions from Yugoslavia.Omnibuswas an important part of a popularization of world music and dance as part of a greater arts and cultural literacy campaign in the 1950s, aimed at educatingandentertaining the average American. As the US government sought to “promote world peace” through the multifaceted economic interventions of endeavors like the Marshall Plan, private organizations such as the Ford Foundation also spent massive sums in the US and abroad. This article contributes to a broader understanding of US postwar cultural diplomacy by examining how international musical guests onOmnibushelped develop an American self-concept that was culturally and politically internationalist.