bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical Composition and Possible in vitro Antigermination Activity of Three Hypericum Essential Oils
Authors: Marandino Aurelio , Martino Laura De , Mancini Emilia , Milella Luigi , Feo Vincenzo De 
Published: March 2019

The essential oils of Hypericum perforatum, H. perfoliatum and H. hircinum, growing in Southern Italy, were analyzed by GC and GC/MS. In the three oils, 111 compounds in all were identified: 53 for the oil of H. hircinum (93.7% of the total oil), 55 for H. perforatum (96.5% of the total oil) and 63 for H. perfoliatum (98.7% of the total oil). The major fraction of the essential oils of H. perforatum and H. hircinum was represented by sesquiterpene hydrocarbons, while the monoterpene α-pinene, and the phenol thymol were the most abundant compounds in the essential oil of H. perfoliatum. The oils were evaluated for their potential in vitro phytotoxic activity against germination and early radicle elongation of Raphanus sativus and Lepidium sativum. The germination of this latter was significantly inhibited by the essential oil of H. hircinum, at the highest doses tested, whereas radicle elongation of garden cress was significantly inhibited by the essential oils of H. perfoliatum and H. hircinum. The radicle elongation of radish was inhibited by the essential oil of H. hircinum to a major extent and by H. perforatum and perfoliatum in a minor measure.
Randomized controlled trial: a pilot study of a psychoeducational intervention for fatigue in patients with quiescent inflammatory bowel disease
Authors: O’Connor Anthony , Ratnakumaran Raguprakash , Warren Lisa , Pullen Debbie , Errington Anna , Gracie David J. , Sagar Rebecca C. , Hamlin P. John , Ford Alexander C. 
Published: March 2019

Introduction: Fatigue is a frequent, debilitating symptom of inflammatory bowel disease (IBD). Despite this, studies report dissatisfaction among IBD patients regarding how little attention is given to fatigue-related issues during consultations. We performed a pilot randomized controlled trial (RCT) to assess whether a brief, structured, multidisciplinary psychological support program improved fatigue, mood and quality of life indices in patients with quiescent IBD. Methods: The intervention consisted of three small-group psychoeducational sessions over 6 months. Primary outcomes were effect on fatigue severity and impact scores. Secondary outcomes included effect on depression, anxiety, somatization scores, generic and disease-specific quality of life. Results: Twenty-three patients were enrolled, 10 in the intervention arm and 13 controls. Mean fatigue severity and impact scores improved for patients in the intervention group (by 14.5–13.1 and 49.7–45.8, respectively), and worsened in controls (by 11.5–12.6 and 33.5–35 respectively). Mean Short Form 36 (SF-36) scores for role limitations due to physical health decreased from 44.4 to 38.9 in the intervention group, but increased from 44.2 to 51.9 among controls. Energy scores in the intervention group improved from 17.8 to 26.6, but only from 31.4 to 31.7 among controls. Short IBD questionnaire scores improved in both groups, from 46.2 to 45.2 in controls compared with 44.4–40 in the intervention group. Discussion: In this small pilot RCT, positive effects were demonstrated on fatigue, energy levels and other quality of life outcomes. Larger, adequately powered studies with longer follow up are required. ClincialTrials.gov identifier: NCT02709434.
The impact of antecedent primary malignancy in soft tissue sarcoma patients
Authors: Torigoe Tomoaki , Imanishi Jungo , Yazawa Yasuo , Kadono Yuho , Oda Hiromi 
Published: March 2019

Background: It is unclear whether antecedent primary malignancies (APMs) have any negative impact on the prognosis of soft tissue sarcoma (STS). We retrospectively reviewed STS patients with APMs (STS-APM) and compared their survival to those of STS only (STS-O). Methods: Twenty-one cases of STS-APM from 2008 to 2017 in our institution were analyzed. One hundred and seventy cases of STS-O at the same period were compared as a control group. Overall survival was estimated using Kaplan–Meier survival curves and prognostic factors were analyzed using logistic regression analyses and contingency table analyses. Results: As the final status of STS-APM patients, 12 patients were in disease-free survival, 5 were alive with disease, 3 have died of disease, and 1 has died of another disease. There was no case that died of APM. The 5-year overall survival rates were 88% in STS-APM and 78% in STS-O, showing no statistical significant ( p = 0.65). The 5-year overall survival rates in each stage of STS-APM and STS-O were 100/100% in stage I, 100/85% in stage II, 86/72% in stage III, and the 3-year overall survival rates were 67/51% in stage IV, with no statistical significance. With regard to prognostic factor, histological grade of STS was the only significant factor. Although antecedent radiotherapy tended to show a high odds ratio, the association was not statistically significant. Antecedent chemotherapy did not show any estimated prognostic risk. Conclusions: Our study suggested that APM in STS patient would not be a negative prognostic factor.
Return to Sport at 6 Months After Shoulder Surgery
Authors: Weber Amy , Paraparan Ragu , Lam Patrick H. , Murrell George A.C. 
Published: March 2019

Background: Many surgical procedures are intended to return patients to sport early, but it is unknown how realistic these expectations are after shoulder surgery. Purpose: To determine which of the commonly performed surgical interventions in the shoulder best facilitated return to sport, and which did not, by 6 months postoperatively. Study Design: Cohort study; Level of evidence, 3. Methods: The study was a retrospective analysis of prospectively collected data from patients who underwent shoulder surgery from a single surgeon over 12 years. To be included, at least 20 patients needed to have undergone that procedure and complete a questionnaire evaluating their shoulder’s function preoperatively and 6 months postoperatively. The primary outcome was a change in the response to the question, “What is your current level of sport?” Results: A total of 2261 surgical procedures in 13 categories met the inclusion criteria. Capsular release was the only procedure associated with improved patient-reported sporting level at 6 months ( d = 0.18 [95% CI, 0.05-0.30]; P = .009). This represented a mean improvement of 41% from the preoperative sporting level. Bankart repair was associated with the greatest decrease in patient-reported sporting level at 6 months (mean decline of 21%) ( d = –0.17 [95% CI, –0.34 to –0.01]; P = .034), followed by rotator cuff repair (mean decline of 13%) ( d = –0.06 [95% CI, –0.03 to –0.10]; P = .0004). There were no significant changes in sporting level at 6 months postoperatively for rotator cuff repair with acromioplasty, polytetrafluoroethylene (PTFE) patch repair, acromioplasty, superior labral anterior to posterior (SLAP) repair, total shoulder arthroplasty, reverse total shoulder arthroplasty, rotator cuff repair with capsular release, rotator cuff repair with stabilization, calcific debridement, or hemiarthroplasty. Conclusion: Capsular release was the only surgical procedure that provided a significant improvement in patient-reported sporting level in a relatively short period of time (6 months). Patients who underwent rotator cuff repair and Bankart repair were the only surgical groups that reported a significant decline in sporting level 6 months postoperatively.
Relation Between Health-Care Medical Provider Opinion and Hemodialysis Patient Attitude Toward Fasting in Ramadan
Authors: El-Kannishy Ghada , Elsawaf Reham , Tarek Elsaber Rana , Magdi Elbanasawi Hebatalla , Magdi Elbahnasawi Menatalla , Latif Soha Ali Abdel , Megahed Abir , Sayed-Ahmed Nagy 
Published: March 2019

Introduction: Muslim hemodialysis (HD) patients are motivated to practice fasting in Ramadan. Health-care providers may be unable to make a recommendation based on lack of evidence. The aim of the present study was to investigate patients’ and medical professionals’ opinion toward fasting in 4 HD centers in Egypt as well as the impact of physicians’ attitude on their patient behavior. Materials and Methods: This observational multicentric study was conducted on 161 patients undergoing HD and 23 physicians in 4 HD centers in Egypt just after Ramadan 1438 Hijri. Patients’ demographic characteristics as well as any associated comorbidities were recorded. Patients and physician were interviewed and were asked about their opinion toward fasting in HD patients and any experienced complications during fasting. Results: Eighty-one (50.3%) patients of the studied HD patients practiced fasting in Ramadan. No statistical difference was observed between fasting and nonfasting groups regarding age, gender, and duration of HD. Eighty percent of patients reported no complications. Fifteen (65.2%) physicians support the opinion that HD patients are capable to fast with precautions. There was a significant variation in fasting frequency among HD patients in the studied centers with a significantly low fasting frequency observed in the third center (10.5%). Most physicians from this HD center adopted that HD patients should not fast. Conclusion: HD patients were keen to practice fasting in Ramadan and were to a considerable extent capable of completing this Islamic worship. Patient decision seems to be affected by their physician’s opinion. Absence of clear recommendations to guide fasting in Ramadan in HD patients as in diabetic patients makes permission or prohibition of such practice unjustified.
Familial predisposition to TP53/complex karyotype MDS and leukemia in DNA repair-deficient xeroderma pigmentosum
Authors: Sarasin Alain , Quentin Samuel , Droin Nathalie , Sahbatou Mourad , Saada Véronique , Auger Nathalie , Boursin Yannick , Dessen Philippe , Raimbault Anna , Asnafi Vahid , Schmutz Jean-Luc , Taïeb Alain , Menck Carlos F. M. , Rosselli Filippo , La Rochelle Laurianne Drieu , Robert Caroline , Sicre de Fontbrune Flore , Sébert Marie , Leblanc Thierry , Kannouche Patricia , De Botton Stéphane , Solary Eric , Soulier Jean 
Published: March 2019

Abstract
There is a Blood Commentary on this article in this issue.
Physiological and Pathological Androgen Actions in the Ovary
Authors: Astapova Olga , Minor Briaunna M N , Hammes Stephen R 
Published: March 2019

Abstract
Androgens, although traditionally thought to be male sex steroids, play important roles in female reproduction, both in healthy and pathological states. This mini-review focuses on recent advances in our knowledge of the role of androgens in the ovary. Androgen receptor (AR) is expressed in oocytes, granulosa cells, and theca cells, and is temporally regulated during follicular development. Mouse knockout studies have shown that AR expression in granulosa cells is critical for normal follicular development and subsequent ovulation. In addition, androgens are involved in regulating dynamic changes in ovarian steroidogenesis that are critical for normal cycling. Androgen effects on follicle development have been incorporated into clinical practice in women with diminished ovarian reserve, albeit with limited success in available literature. At the other extreme, androgen excess leads to disordered follicle development and anovulatory infertility known as polycystic ovary syndrome (PCOS), with studies suggesting that theca cell AR may mediate many of these negative effects. Finally, both prenatal and postnatal animal models of androgen excess have been developed and are being used to study the pathophysiology of PCOS both within the ovary and with regard to overall metabolic health. Taken together, current scientific consensus is that a careful balance of androgen activity in the ovary is necessary for reproductive health in women.
The effect of a one-time 15-minute guided meditation (Isha Kriya) on stress and mood disturbances among operating room professionals: a prospective interventional pilot study
Authors: Rangasamy Valluvan , Thampi Susheela Ammu , Mueller Ariel , F. H. Chang Tracy , Sadhasivam Senthilkumar , Subramaniam Balachundhar 
Published: March 2019

Background: Operating room professionals are exposed to high levels of stress and burnout. Besides affecting the individual, it can compromise patient safety and quality of care as well. Meditation practice is getting recognized for its ability to improve wellness among various populations, including healthcare providers. Methods: Baseline stress levels of perioperative healthcare providers were measured via an online survey using a Perceived Stress Scale (PSS) questionnaire. An in-person meditation workshop was demonstrated during surgical grand rounds and an international anesthesia conference using a 15-minute guided Isha Kriya meditation. The participants were then surveyed for mood changes before and after meditation using a Profile of Mood States (POMS) questionnaire. Results: Surgeons and anesthesiologists were found to have higher median (interquartile range) Perceived Stress Scores as compared to nurses respectively (17 [12, 20] and 17 [12, 21] vs 14 [9, 19]; P = 0.01). Total mood disturbances were found to be significantly reduced after meditation in both the surgical grand rounds (pre-meditation median [IQR] 99 [85, 112] vs 87 [80, 93] post-meditation; P < 0.0001) and anesthesia conference cohorts (pre-meditation 92 [86, 106] vs 87 [81, 92] post-meditation; P < 0.0001). Conclusions: Isha Kriya, a guided meditation, is easy to learn and takes less than 15 minutes to complete. This meditation technique improves mood changes and negative emotions among operating room professionals and could be used as a potential tool for improving wellness.
RESENHA CRÍTICA: TRAJETÓRIAS DE PESQUISAS DA REDE “MOVER"
Authors: Carneiro Cruz Pedro José Santos 
Published: March 2019

As trajetórias de pesquisas realizadas pelo Grupo de Pesquisa “Educação Intercultural Movimentos Sociais” (CNPq/UFSC), conhecido como núcleo ou rede “Mover”, são aqui analisadas sob a perspectiva da extensão universitária popular, entendida como mergulho permanente, sistemático e profundo na realidade social. Neste sentido, a experiência do “Mover” aparece como um processo intenso de comunicação dialógica e engajada com os movimentos populares que enseja, reciprocamente, o empoderamento dos movimentos populares como protagonistas de sua “práxis” e a construção social permanente da universidade popular.
A Novel Approach for the Genetic Analysis of Biliary Tract Cancer Specimens Obtained Through Endoscopic Ultrasound-Guided Fine Needle Aspiration Using Targeted Amplicon Sequencing
Authors: Hirata Koji , Kuwatani Masaki , Suda Goki , Ishikawa Marin , Sugiura Ryo , Kato Shin , Kawakubo Kazumichi , Sakamoto Naoya 
Published: March 2019

OBJECTIVES:
Biliary tract cancer (BTC) is an aggressive malignant tumor, and biomarker-based clinical trials for this cancer are currently ongoing. Endoscopic ultrasound–guided fine needle aspiration (EUS-FNA) is a safe procedure and enables pathological diagnoses; however, it is uncertain whether a tiny tumor sample of BTC obtained through EUS-FNA can be analyzed for diverse genetic alterations in the development and tolerance of BTC. Thus, we aimed to verify the feasibility of genetic analyses with EUS-FNA samples of BTC.

METHODS:
Targeted amplicon sequencing using a cancer gene panel with 50 genes was performed with tissue samples of 21 BTC patients obtained through EUS-FNA with a novel rapid on-site process compared with paired peripheral blood samples.

RESULTS:
Pathogenic gene alterations were successfully identified in 20 out of 21 patients (95.2%) with EUS-FNA specimens of BTC, which included 19 adenocarcinomas and 2 adenosquamous carcinomas. Eighty single nucleotide variants and 8 indels in 39 genes were identified in total, and 28 pathogenic alterations in 14 genes were identified (average, 1.4 alterations per patient). The most common alterations were TP53, KRAS, and CDKN2A in gallbladder carcinoma; TP53, KRAS, PIK3CA, and BRAF in intrahepatic cholangiocarcinoma; and TP53 and SMAD4 in extrahepatic cholangiocarcinoma. Actionable gene alterations (BRAF, NRAS, PIK3CA, and IDH1) were identified in 7 out of 21 patients.

CONCLUSIONS:
A novel approach in genetic analysis using targeted amplicon sequencing with BTC specimens obtained through EUS-FNA was feasible and enabled us to identify genomic alterations.
The influence of dietary protein and energy levels on the performance, meat bone ratio and meat chemical composition of SenSi-1 Agrinak chicken
Authors: Hidayat Cecep , Iskandar Sofjan 
Published: March 2019

<p class="Default"><span lang="EN-US">Sensi-1 Agrinak is a strain of the improved native chickens for meat production in Indonesia. The objective of </span><span lang="IN">this</span><span lang="EN-US"> study was to investigate influence of different dietary energy and protein levels on </span><span lang="IN">p</span><span lang="EN-US">erformance, meat bone ratio</span><span lang="IN">,</span><span lang="EN-US"> and meat chemical composition of Sensi-1 Agrinak chicken, reared until 10 weeks of age. Two hundred and sixteen of unsexed day old chickens (DOC) of Sensi-1 Agrinak were subjected to six experimental rations differed in dietary crude protein (CP) content,. </span><span lang="IN">Namely:</span><span lang="EN-US"> 21;19; and 17 % and dietary metabolizable energy (ME) (2800 and 3000 kcal/kg). Each treatment combination was replicated four times and fed from day old to 10 weeks old. In each treatment combination there were nine unsexed-DOCs. The parameters observed were performance (i.e. live weight, feed intake, viability, FCR), economic index (European Production Efficiency Factor/EPEF), meat bone ratio, and meat chemical composition. </span><span lang="IN">R</span><span lang="EN-US">esult showed that </span><span lang="EN-US">increas</span><span lang="IN">ed</span><span lang="EN-US"> of dietary CP level increased live weight and EPEF (p&lt;0.05). Sensi-1 Agrinak chicken had the best FCR (2.59), when fed diet containing 21% CP and 3000 kcal/kg. Increas</span><span lang="IN">ed</span><span lang="EN-US"> dietary CP level increased the meat-bone ratio of breast, thighs, and drumsticks. Meanwhile, increas</span><span lang="IN">ed</span><span lang="EN-US"> levels of dietary CP and ME did not affect (p&gt;0.05) meat chemical composition. It </span><span lang="IN">is</span><span lang="EN-US"> concluded that optimal dietary levels of crude protein and energy for unsexed Sensi-1 Agrinak chicken up to 10 weeks of age were 21% CP and 3000 kcal/kg.</span></p>
TÜRKİYE’DEKİ SURİYELİ MÜLTECİLERİN YÜKSEKÖĞRETİM SORUNLARI: ADIYAMAN ÜNİVERSİTESİ ÖRNEĞİ
Authors: TAŞAR Hacı Hüseyin 
Published: March 2019

İçişleri Bakanlığı Göç İdaresi Genel Müdürlüğü 8 Kasım 2018 tarihi
itibarıyla Türkiye’deki kayıtlı Suriyeli sayısı bir önceki aya göre 8 bin 494
kişi artarak toplam 3 milyon 594 bin 232 kişiyi bulduğunu
açıklamıştır. Bu kişilerin 1 milyon 950 bin 182’si erkeklerden, 1 milyon 644
bin 50’si ise kadınlardan oluşmaktadır. Türkiye’ye göç eden
Suriyeli erkeklerin sayısı, kadınlardan 306 bin 32 kişi daha fazladır. Yüksek
öğrenim çağı (19-24 yaş) aralığında yer
alan Suriyeli sayısı 534 bin 248 kişidir. Türkiye devleti, ülkesinde
bulunan yüksek öğrenim çağındaki gençlere eğitim fırsatları sunmak
için önemli adımlar atmıştır. Bu araştırmanın amacı, iç savaş nedeniyle Türkiye’ye
göç eden Suriyeli öğrencilerin yükseköğretime ilişkin sorunlarını
Adıyaman üniversitesi özelinde tespit etmek ve öneriler sunmaktır. Çalışma
nitel araştırma temelinde desenlenen bir durum çalışması olup, araştırmanın evrenini,
Adıyaman Üniversitesinde okuyan öğrenciler oluşturmaktadır. Araştırmada elde
edilen verilerin incelenmesinde betimsel analiz tekniği kullanılmıştır.
Araştırmada; Suriyeli öğrencilerin kendilerini, arkadaşlarına, görevlilere ve
ders hocalarına tam olarak ifade edemedikleri, hocaların derslerde hızlı
konuştukları, sınavlarda kendilerine yeterli düzeyde ek süre verilmediği,
kapalı soruların yeterince açıklanmadığı belirlenmiştir.
TÜRKİYE'DE YENİ MEDYA VE TV ETKİLEŞİMİ BAĞLAMINDA DEĞİŞEN DİZİ ANLAYIŞI: SIFIR BİR "BİR ZAMANLAR ADANA'DA" ÖRNEĞİ
Authors: KIRIK Ali Murat , ÇELEBİOĞLU Sabri 
Published: March 2019

İletişim, kişinin sahip olduğu bilgi birikimi ve buna bağlı oluşan
duygu durumlarını, semboller kullanarak bir başka bireye iletmesidir. Kitle
iletişimi ise bilginin, dönemin teknolojik ilerlemelerinden faydalanılarak
kitlelere aktarılmasıdır. Kitle iletişim araçları, bilginin geniş kitlelere
yayılmasını olanaklı kılmaktadır. Kitle iletişim araçları; yazılı,
görsel-işitsel ve teknolojik araçlardan oluşur. Gazete, dergi, TV, radyo, cep
telefonu, bilgisayar vb. gibi iletişim organları, kitle iletişim araçlarına
örnek oluşturmaktadır. Kitle iletişiminde yeri olan medyanın
'yeni' adı altında
değişme süreci ve getirileri bağlamında yola çıkılan bu çalışma, toplam
dört bölümden oluşmaktadır. Çalışmada dizi
sektörünün Türkiye'de nasıl geliştiği, bu sektörün kültürel-toplumsal-bireysel
etkileri, alışkanlıkların değişme süreci, yeni neslin televizyonu olan YouTube
platformu ve bu sayede yetişen mobil izleyici kitlesi detaylı olarak
incelenmiştir. Sıfır Bir “Bir zamanlar Adana'da” dizisinin konusu,
karakterleri, şiddet ve gerçeklik unsurları çerçevesinde ayrıntılı olarak ele
alınmıştır. Çalışmada dizinin YouTube’da
yayınlanmasından dolayı izleyici kitlesi genel olarak genç kuşak olduğu
neticesine ulaşılmıştır. Araştırmaya
katılanların %18,4’ü 18-24 yaşında ve bunların %82’si bu dizi izlediğini belirtmiştir.
İzleyenlerin cinsiyetlerinin ise %75,4 oranında erkek olduğu görülmüştür.
Subcutaneous adipose tissue distribution and telomere length
Authors: Mangge Harald , Renner Wilfried , Almer Gunter , Gruber Hans-Jürgen , Zelzer Sieglinde , Moeller Reinhard , Horejsi Renate , Herrmann Markus 
Published: March 2019

Abstract

Background
Overweight and obese individuals have a reduced life expectancy due to cardiovascular disease (CVD), type 2 diabetes, stroke and cancer. Systemic inflammation and premature telomere shortening have been discussed as potential mechanisms linking these conditions. We investigated the relation of subcutaneous adipose tissue (SAT) distribution to leukocyte relative telomere length (RTL).

Methods
We measured RTL in 375 participants of the observational STYJOBS/EDECTA cohort (ClinicalTrials.gov Identifier NCT00482924) using a qPCR based method. SAT distribution was determined by lipometry yielding a percent body fat value and SAT thicknesses at 15 standardized locations across the entire body. A correlation analysis between RTL, age, sex, lipometry data and conventional body measures (body mass index [BMI], waist-, hip circumference, waist-to-hip ratio, waist-to-height ratio) was calculated. The strongest determinants of RTL were determined by a stepwise multiple regression analysis.

Results
RTL was not associated with age or sex. RTL was significantly negatively correlated with BMI, percent body fat, waist-, hip circumference and waist-to-height ratio. Furthermore, RTL correlated with SAT at the following locations: neck, triceps, biceps, upper back, front chest, lateral chest, upper abdomen, lower abdomen, lower back, hip, front thigh, lateral thigh, rear thigh and calf. Stepwise regression analysis revealed nuchal and hip SAT as the strongest predictors of RTL. No significant association was seen between RTL and waist-to-hip ratio.

Conclusions
RTL is negatively associated with parameters describing body fat composure. Nuchal and hip SAT thicknesses are the strongest predictors of RTL. Central obesity appears to correlate with premature genomic aging.
Crystal structure of poly[diaqua-bis(μ2-1-(4-(1H-imidazol-1-yl)benzyl)-1H-1,2,4-triazole-κ2
N:N′)manganese(II)] terephthalate tetrahydrate, MnC32H38N10O10
Authors: Zhu Xia 
Published: March 2019

Abstract
MnC32H38N10O10, triclinic, P1̄ (no. 2), a = 8.508(2) Å, b = 8.659(3) Å, c = 12.755(4) Å, α = 71.120(10)°, β = 84.432(16)°, γ = 88.133(16)°, V = 885.0(5) Å3, Z = 1, R
gt(F) = 0.0371, wR
ref(F
2) = 0.1040, T = 223(2) K.