bluuebunny/crossref_metadata_2025_split huggingface dataset:
Common variable immune deficiency: Dissection of the variable
Authors: Cunningham‐Rundles Charlotte 
Published: December 2018

SummaryStarting about 60 years ago, a number of reports appeared that outlined the severe clinical course of a few adult subjects with profound hypogammaglobinemia. Puzzled by the lack of family history and adult onset of symptoms in most, the name “acquired” hypogammaglobinemia was given, but later altered to the current name common variable immune deficiency. Pathology reports remarked on the loss of lymph node architecture and paucity of plasma cells in lymphoid tissues in these subjects. While characterized by reduced serum IgG and IgA and often IgM, and thus classified among the B‐cell defects, an increasing number of cellular defects in these patients have been recognized over time. In the early years, severe respiratory tract infections commonly led to a shortened life span, but the wide spread availability of immune globulin concentrates for the last 25 years has improved survival. However, chronic non‐infectious inflammatory and autoimmune conditions have now emerged as challenging clinical problems; these require further immunologic understanding and additional therapeutic measures. Recent study of this phenotypic syndrome have provided an increasingly fertile ground for the identification of autosomal recessive and now more commonly, autosomal dominant gene defects which lead to the loss of B‐cell development in this syndrome.
Adolescent patterns of peer victimization: Concurrent and longitudinal health correlates
Authors: Ames Megan E. , Leadbeater Bonnie J. , Merrin Gabriel J. , Sturgess Clea M. B. 
Published: December 2018

AbstractPurposeWe examined how heterogeneity in the patterns of adolescent experiences of different types and severity of peer victimization is associated with concurrent and longitudinal mental health, substance use, and physical health.MethodData come from a randomly recruited community‐based sample of youth (T1 ages 12–18; N = 662; 52% female) followed biennially across 10 years (T6 ages 22–29; n = 478; 55% female).ResultsUsing latent class analysis, we identified four classes of adolescent peer victimization: Low victimization (63%), Physical victimization only (15%), Relational victimization only (17%), and Poly‐victimization (6%). Youth in the Poly‐victimization class reported the most detrimental health consequences in adolescence (e.g., internalizing and externalizing symptoms, illicit drug use, physical symptoms, poor physical self‐concept, physical activity) and in young adulthood (e.g., depressive symptoms, sleep problems). Youth in the Relational and Physical victimization classes also reported health problems, some of which persisted into young adulthood. Youth in the Low victimization class reported the fewest health concerns.ConclusionsFindings add to our understanding of how different types of adolescent victimization are related to mental health, substance use, and physical health problems both within adolescence and long‐term.
Beyond working conditions, psychosocial predictors of job satisfaction, and work engagement among French dentists and dental assistants
Authors: Chevalier Séverine , Fouquereau Evelyne , Bénichoux Florence , Colombat Philippe 
Published: December 2018

AbstractObjectivesUsing Job Demands and Resources Theory (Demerouti & Bakker, 2011,South African Journal of Industrial Psychology, 37, 1) as the guiding theoretical framework, the present study tested a model that included working condition variables (i.e., remuneration, workplace ergonomics, and work area), two psychosocial factors (i.e., perceived organizational support and psychological meaningfulness of work), and job satisfaction and work engagement among French dentists and dental assistants.MethodA sample of 218 French self‐employed dentists and 143 dental assistants were surveyed via a self‐administered questionnaire.ResultsMultiple regression analysis revealed that the model accounted for 44% of variance in overall job satisfaction for dentists and 64% for dental assistants. In addition, the same model accounted for 39% of variation in overall work engagement for dentists and 50% for dental assistants. For both groups, the greatest part of the variance of job satisfaction and engagement at work was explained by psychosocial variables.DiscussionThis study underscores the importance of psychosocial factors in job satisfaction and engagement at work among dental teams. It also provides a more comprehensive understanding of these relationships.
A strategy for defects healing in 3D printed ceramic compact via cold isostatic pressing: Sintering kinetic window and microstructure evolution
Authors: An Di , Liu Wei , Xie Zhipeng , Li Hezhen , Luo Xudong , Wu Haidong , Huang Meipeng , Liang Jianwei , Tian Zhuo , He Rongxuan 
Published: December 2018

AbstractIn this study, we developed a unique defect healing method for 3D printed ceramic compact via cold isostatic pressing (CIP) after debinding, and typical features of interlayer interface defects of 3D‐printed zirconia compact were characterized and found to be reduced significantly. The characteristic sintering kinetics window and microstructure evolution of the healed sintered bodies were systematically investigated, which was found to be quite different from conventional shaping methods. The three sintering stages are probed by their feature microstructure details such as the mechanically flattening surface at the early sintering stage, the heterogeneous microstructure and high porosity in the interlayer interface region at the middle stage, and the slightly ripple‐like structural features combined with the healed interlayer defects at the final stage. The evolution of the pore structure of the healed 3D printed bodies were traced and the mechanical properties such as the Young's modulus, hardness, and fracture toughness were measured to understand the significance of the heal effect.
A multifunctional Ag/TiO2/reduced graphene oxide with optimal surface‐enhanced Raman scattering and photocatalysis
Authors: Wang Yanfen , Zhang Miao , Fang Lulu , Yang Haocheng , Zuo Yong , Gao Juan , He Gang , Sun Zhaoqi 
Published: December 2018

AbstractA multifunctional Ag/TiO2/reduced graphene oxide (rGO) ternary nanocomposite was prepared by a one‐step photochemical reaction with TiO2 and Ag nanoparticles successively deposited on reduced graphene oxide. The structure, morphology, composition, optical, and photoelectrochemical properties of Ag/TiO2/rGO were investigated in detail. Meanwhile, the ternary nanocomposite possessed much higher adsorption capacity to organic dyes compared with bare TiO2 and binary Ag/TiO2, which would help to its use for surface‐enhanced Raman scattering detection and photocatalytic degradation. Due to the charge transfer between rGO and organic dyes and enhanced electromagnetic mechanism of Ag, Ag/TiO2/rGO nanocomposites as surface‐enhanced Raman scattering substrates demonstrated dramatically improved sensitivity and good uniformity. The detection limit of rhodamine 6G (R6G) was as low as 10−9 mol/L, and the relative standard deviation values of the intensities remained below 5%. Most importantly, the synergistic coupling effect of three components extended the photoresponse range and accelerated separation of the electron‐hole pairs, leading to greatly improved photocatalytic activity under simulated sunlight. The maximum rate constant (k, 0.06243 min−1) of Ag/TiO2/rGO was 50 and four times higher than that of TiO2 and Ag/TiO2, respectively.
Production and characterization of durable self‐cleaning and engineering porous Al2O3/CaAl12O19 ceramic membranes
Authors: Dong Binbin , Yang Mingye , Wang Feihong , Wang JunWei , Hao LuYuan , Xu Xin , Wang Gang , Agathopoulos Simeon 
Published: December 2018

AbstractThe rapid development of engineering filtering process suggests that it is imperative to produce membrane substrates with a fine pore size, high gas permeation, and antifouling properties for efficient and long‐term application. This study reports on a novel fabrication method of a porous Al2O3/CaAl12O19 ceramic membrane substrate by a direct foaming method combined with cement solidification and tape‐casting technology. The microstructure of the produced ceramic membrane consisted of pores with a size of 50‐150 μm, which were interconnected with each other with a large number of small filtering functional pores of <10 μm. By increasing the amount of the foaming agent, the porosity of the porous Al2O3/CaAl12O19 ceramic membranes was tailored from 64.8% to 80.5%, and the bending strength decreased from 32.1 ± 1.0 to 9.6 ± 0.9 MPa, respectively. The sintered hydrophilic ceramic substrate was successfully modified to a hydrophobic one (with water contact angles of 143°) by pyrolysis of dimethyldichlorosilane and dichloromethylsilane. The resultant membrane displayed high chemical stability and self‐cleaning features. The membrane with a porosity of 64.8% had a N2 permeation of 3.0 (±0.5) × 107 L m−2 h−1 at 0.5 bar and a water flux which could be totally suppressed at a liquid entry pressure of 0.45 bar.
Fracture and property relationships in the double diboride ceramic composites by spark plasma sintering of TiB2 and NbB2
Authors: Demirskyi Dmytro , Solodkyi Ievgen , Nishimura Toshiyuki , Vasylkiv Oleg O. 
Published: December 2018

AbstractBulk titanium diboride–niobium diboride ceramic composites were consolidated by spark plasma sintering (SPS) at 1950°C. SPS resulted in dense specimens with a density exceeding 98% of the theoretical density and a multimodal grain size ranging from 1 to 10 μm. During the SPS consolidation, the pressure was applied and released at 1950 and 1250°C, respectively. This allowed obtaining a two‐phase composite consisting of TiB2 and NbB2. For these ceramics composites, we evaluated the flexural strength and fracture toughness and room and elevated temperatures. Room‐temperature strength of thus produced bulks was between 300 and 330 MPa, at 1200°C or 1600°C an increase in strength up to 400 MPa was observed. Microstructure after flexure at elevated temperatures revealed the appearance of the needle‐shape subgrains of NbB2, an evidence for ongoing plastic deformation. TiB2–NbB2 composites had elastic loading stress curves at 1600°C, and at 1800°C fractured in the plastic manner, and strength was ranged from 300 to 450 MPa. These data were compared with a specimen where a (Ti,Nb)B2 solid solution was formed during SPS to explain the behavior of TiB2–NbB2 ceramic composites at elevated temperatures.
Accounting for population structure in selective cow genotyping strategies
Authors: Perez Bruno C. , Balieiro Julio C. C. , Carvalheiro Roberto , Tirelo Fabio , Oliveira Junior Gerson A. , Dementshuk Juliana M. , Eler Joanir P. , Ferraz José B. S. , Ventura Ricardo V. 
Published: December 2018

AbstractThe objective of the present study was to investigate the impact of considering population structure in cow genotyping strategies over the accuracy and bias of genomic predictions. A small dairy cattle population was simulated to address these objectives. Based on four main traditional designs (random, top‐yield, extreme‐yield and top‐accuracy cows), different numbers (1,000; 2,000 and 5,000) of cows were sampled and included in the reference population. Traditional designs were replicated considering or not population structure and compared among and with a reference population containing only bulls. The inclusion of cows increased accuracy in all scenarios compared with using only bulls. Scenarios accounting for population structure when choosing cows to the reference population slightly outperformed their traditional versions by yielding higher accuracy and lower bias in genomic predictions. Building a cow‐based reference population from groups of related individuals considering the frequency of individuals from those same groups in the validation population yielded promising results with applications on selection for expensive‐ or difficult‐to‐measure traits. Methods here presented may be easily implemented in both new or already established breeding programs, as they improved prediction and reduced bias in genomic evaluations while demanding no additional costs.
LncRNA MEG3 inhibits the progression of prostate cancer by modulating miR‐9‐5p/QKI‐5 axis
Authors: Wu Meng , Huang Yawei , Chen Tongchang , Wang Weichao , Yang Shiguang , Ye Zhenfeng , Xi Xiaoqing 
Published: December 2018

AbstractThis study was designed to detecting the influences of lncRNA MEG3 in prostate cancer. Aberrant lncRNAs expression profiles of prostate cancer were screened by microarray analysis. The qRT‐PCR and Western blot were employed to investigating the expression levels of lncRNA MEG3, miR‐9‐5p and QKI‐5. The luciferase reporter assay was utilized to testifying the interactions relationship among these molecules. Applying CCK‐8 assay, wound healing assay, transwell assay and flow cytometry in turn, the cell proliferation, migration and invasion abilities as well as apoptosis were measured respectively. LncRNA MEG3 was a down‐regulated lncRNA in prostate cancer tissues and cells and could inhibit the expression of miR‐9‐5p, whereas miR‐9‐5p down‐regulated QKI‐5 expression. Overexpressed MEG3 and QKI‐5 could decrease the abilities of proliferation, migration and invasion in prostate cancer cells effectively and increased the apoptosis rate. On the contrary, miR‐9‐5p mimics presented an opposite tendency in prostate cancer cells. Furthermore, MEG3 inhibited tumour growth and up‐regulated expression of QKI‐5 in vivo. LncRNA MEG3 was a down‐regulated lncRNA in prostate cancer and impacted the abilities of cell proliferation, migration and invasion, and cell apoptosis rate, this regulation relied on regulating miR‐9‐5p and its targeting gene QKI‐5.
FAM3B promotes progression of oesophageal carcinoma via regulating the AKT–MDM2–p53 signalling axis and the epithelial‐mesenchymal transition
Authors: He Song‐Lin , Wang Wen‐Ping , Yang Yu‐Sang , Li En‐Min , Xu Li‐Yan , Chen Long‐Qi 
Published: December 2018

AbstractFAM3B has been suggested to play important roles in the progression of many cancers, such as gastric, oral, colon and prostate cancer. However, little is known about the role of FAM3B in human esophageal squamous cell carcinoma (ESCC). In the present study, we found that FAM3B expression was higher in ESCC tissues than in adjacent normal tissues. Using quantitative real‐time polymerase chain reaction, we found similar results in cell lines. FAM3B expression was significantly related to T/TNM stage. Importantly, Kaplan–Meier analysis revealed that a high expression level of FAM3B predicted a poor outcome for ESCC patients. Overexpression of FAM3B inhibits ESCC cell death, increases oesophageal tumour growth in xenografted nude mice, and promotes ESCC cell migration and invasion. Further studies confirmed that FAM3B regulates the AKT–MDM2–p53 pathway and two core epithelial‐to‐mesenchymal transition process markers, Snail and E‐cadherin. Our results provide new insights into the role of FAM3B in the progression of ESCC and suggest that FAM3B may be a promising molecular target and diagnostic marker for ESCC.
Signature of circular RNAs in peripheral blood mononuclear cells from patients with active tuberculosis
Authors: Fu Yurong , Wang Jindong , Qiao Jinjuan , Yi Zhengjun 
Published: December 2018

AbstractThe study was to characterize the expression profiles of circular RNAs (circRNAs) in peripheral blood mononuclear cells (PBMCs) from active tuberculosis (TB) patients and to investigate their function. Microarray was applied to detect circRNA expression and reverse transcription‐quantitative polymerase chain reaction was conducted to validate the microarray results. Meanwhile, receiver operating characteristic curve (ROC) curve was calculated to evaluate the predictive power of the selected circRNAs for TB diagnosis. Additionally, circRNA/miRNA interaction was predicted based on miRNA target prediction software, and gene ontology as well as Kyoto Encyclopedia of Genes and Genomes pathway analysis were used to predict their biological function. In total, 171 circRNAs were found to be dysregulated in TB samples. Specifically, circRNA_103017, circRNA_059914 and circRNA_101128 were confirmed to be increased, while circRNA_062400 was decreased in TB samples. ROC analysis revealed that circRNA_103017 had potential value for TB diagnosis, followed by circRNA_059914 and circRNA_101128. Moreover, circRNA_101128 expression in TB samples was negatively correlated with the level of its possible target let‐7a and bioinformatics analysis showed that circRNA_101128 was potentially involved in MAPK and P13K‐Akt pathway possibly via modulation of let‐7a. Taken together, our results indicated that some dysregulated circRNAs were potential biomarkers for the diagnosis of TB and circRNA_101128‐let‐7a interplay may play considerable role in PBMCs response to Mtb infection.
Multiobjective process optimization for betaine enriched spelt flour based extrudates
Authors: Kojić Jovana S. , Ilić Nebojša M. , Kojić Predrag S. , Pezo Lato L. , Banjac Vojislav V. , Krulj Jelena A. , Bodroža Solarov Marija I. 
Published: December 2018

AbstractThe main purposes of this work are successful modeling of twin‐screw extrusion process using predictive models, investigating the effect of process parameters such as screw speed, feed rate, and feed moisture content on the process and product responses and finally optimizing the process regarding betaine content in the extruded product and energy consumption. The second order polynomial approximation models and the artificial neural network were developed to predict the betaine content, showing the high accuracy in the prediction of experimental results. This study introduces the multiobjective optimization (MOO) approach in the extrusion process of spelt flour. The maximal betaine content (between 1,506.8 and 1,605.2 mg/40 g) and minimal energy consumption (between 101.3 and 108.5 W hr/kg) were indicated by MOO procedure, which were gained using the following input parameters: feed flow rate feed about 24 kg/h, screw speed about 252 RPM and moisture content from 21.6 to 23.4%.Practical applicationsThis study introduces the multiobjective optimization (MOO) approach in the extrusion process of spelt flour, which provides the selection of optimal solution that enables the extruder to reach the optimum conditions of the process and provide decision maker with deeper understanding of the process. The present study analyzes the influence of extrusion cooking parameters like: screw speed, feed flow rate, and feed moisture content on the betaine content in the extrudate product and specific mechanical energy input during the processing of betaine enriched spelt flour based extrudates. One way to improve the intake of betaine in the general population can be to enrich foods with betaine. According to European Breakfast Cereal Association for extruded products portion sizes should be 40 g. Consuming a portion of a functional extrudate product with the addition of betaine (1,500 mg/day) could give expected health effects. Final extrudate product from this study satisfies these statements.
A novel on‐chip solution enabling rapid analysis of melamine and chloramphenicol in milk by smartphones
Authors: Yang Ning , Xie Liang‐Liang , Pan Chen , Yuan Min‐Feng , Tao Zhi‐Han , Mao Han‐Ping 
Published: December 2018

AbstractUbiquitous food security control is desirable. However, the analysis methods, such as those for milk, are highly based on manual analysis, leading to low efficiency. Thus, we report a multilayer paper‐based microfluidic chip transforming chromatic readout to electric signals. First, colloidal gold immunochromatographic assays (GICA) are used to achieve the colorimetric occurrence. Secondly, the test (T) lines and control (C) lines are patterned to encode different EAN‐8 barcode. Furthermore, accurate scanning is accomplished by the automatic threshold segmentation. These technologies make the digital determination of melamine (MEL) and chloramphenicol (CAP) by phone readily accessible. Results indicate that the accurate machine‐scanning can be assured when MEL and CAP is above 30 ng/mL and 6 ng/mL in milk respectively. The detection time is under 8 min, and the stable storage life is over 90 days. Therefore, this simple chip allows rapid, machine‐readable, electric‐recordable diagnostic directly from chromatic assays with satisfying stability, specificity and accuracy.Practical applicationsThis article illustrates a method used to determine the concentration of melamine and chloramphenicol in milk. When melamine and chloramphenicol is above 30 and 6 ng/ml in milk, the produced EAN‐8 barcode can be recognized with high accurate level, compared with international standards, the results are acceptable and sensitive. This method is highly intellectual and environmentally friendly, with the disposable materials and instant smartphone‐readable EAN‐8 results patterns. This article demonstrates a multilayer paper chip based on EAN‐8 encoding rules, colloidal gold nanoparticles, and immunochromatographic assays. The EAN‐8 format assay is achieved by color‐development occurrence of colloidal GICA in different encoding areas of EAN‐8 code, and the analysis device, namely smartphone, is accessible by almost every individual. Therefore, this chip can pave a potential way for massive health control and digital automated analysis for daily life and industrial manufacture.
Effect of UV‐C radiation on Salmonella spp. reduction and oxidative stability of caiman (Caiman crocodilus yacare) meat
Authors: Canto Anna Carolina Vilhena da Cruz Silva , Monteiro Maria Lucia Guerra , Costa‐Lima Bruno Reis Carneiro da , Lázaro Cesar Aquiles , Marsico Eliane Teixeira , Silva Teófilo José Pimentel da , Conte‐Junior Carlos Adam 
Published: December 2018

AbstractNon‐UV‐C dose and 0.005, 0.010, 0.016, 0.037, 0.065, 0.105, 0.127, and 0.199 J/cm2 were applied in inoculated agar plates and in inoculated caiman (Caiman crocodilus yacare) meat to investigate the reduction of Salmonella spp. Moreover, noninoculated caiman meat was submitted to the same treatments and was evaluated for color parameters (L*, a*, b* values, and ΔE) and lipid oxidation. The most effective Salmonella spp. reductions ranged from 6.72 to 7.13 log cfu/g, and from 2.47 to 2.88 log cfu/g in inoculated agar plates and caiman meat treated with 0.105–0.199 J/cm2 and 0.065–0.199 J/cm2 (p < 0.05), respectively. However, these doses increased (p < 0.05) L* values and lipid oxidation, while decreased (p < 0.05) a* and b* values. Therefore, UV‐C at 0.016 J/cm2 is an alternative technology to improve the bacterial quality of caiman meat without negative effects on oxidative parameters.Practical applicationsSalmonella spp. is a potential disease agent being the pathogen more commonly detected in meat and meat products. UV‐C has easy implementation in meat industry, low cost, rapid application, and lack of toxic wastes, which could be an alternative for food industries to produce high‐quality food products without the use of chemical agents to meet consumers demand. Otherwise, UV‐C may induce oxidation depending on type of food, lipid profile, and dose applied, which would limit the meat quality and their industrial application. In this study, eight UV‐C doses (0.005, 0.010, 0.016, 0.037, 0.065, 0.105, 0.127, and 0.199 J/cm2) were applied in inoculated agar plates and caiman meat to investigate Salmonella spp. reduction. Moreover, noninoculated caiman meat was submitted to the same treatments and was evaluated for color parameters and lipid oxidation. UV‐C at 0.016 J/cm2 is an alternative technology to improve bacterial quality of caiman meat without altering the oxidative parameters.