bluuebunny/crossref_metadata_2025_split huggingface dataset:
The main formative material of bay’s estuarial abrasion-accumulative jumpers and it’s interconnection with the lithological composition of Volgograd reservoir coasts
Authors: Baranova M S 
Published: September 2019

Abstract
The article contents results of the data compilation of lithological composition of Volgograd reservoir coasts. The interconnection between the main formative material of bays estuarial abrasion-accumulative jumpers and lithological composition of reservoir coasts was revealed. The principal differences between the material of bays jumpers and lithological composition on the right and the left coasts were determined in this research. An electronic thematic layer “The lithological composition of the coasts of the Volgograd reservoir” was created and the attribute table of this layer was filled. We determined that volumes of bays of the Volgograd reservoir decreased significantly from 1988 to modern time.
Precipitation in the catchment area of the Votkinsk reservoir: nature, type and temporal variability
Authors: Pischalnikova E V , Kalinin N A , Akilov E V 
Published: September 2019

Abstract
The type and nature of precipitation in the catchment area of the Votkinsk reservoir are considered with taking into account its hydrological zoning. Intra-annual frequency, duration and intensity of precipitation are shown. It is determined that 321 days are observed with precipitation per year on average. Daily amount does not exceed 1 mm. In the catchment area, widespread and rain precipitations are observed with a frequency of 51 and 53% respectively. The daily duration of precipitation depending on its type was obtained, which equals 4–6 h for rain and mixed precipitations and 8–10 h for solid precipitation. High precipitation intensity is observed in the northern part of the catchment area, where the terrain contributes to the development of cloudiness and an increase in precipitation intensity.
Trends of climate parameters over Tanzania
Authors: Mikova K D , Msafiri L C 
Published: September 2019

Abstract
Analysis of the climate parameters over Tanzania were done for period 57-61 years. Rainfall and wind speed had greater variability than air temperatures. Positive significant trend of dry air temperature, maximal and minimal air temperatures were detected almost for all weather stations. As well positive trends of wind speed were detected just for stations Dodoma, Arusha, Mtwara and Mwanza. While rainfall trend analysis just for station Mtwara showed negative significant trend. In absolute values wind speed increased by 0.7-1.1 m/s, rainfall decreased by 89.3-136.1 mm, dry air temperature rise up 0.5-1.0 °C, maximal and minimal air temperatures values have grown by 2.0-3.6 °C.
Geoecological evaluation of environmental damage to the results of long-term dynamics of benzopyrene and petroleum within landfill sludge
Authors: Dregulo A M , Pitulko V M , Rodionov V Z , Kulibaba V V , Petukhov V V 
Published: September 2019

Abstract
The article deals with the problems of environmental pollution with benzapyrene and petroleum products contained in sewage sludge. The dynamics of changes in the concentrations of benzapyrene and petroleum products in the soils of the object of accumulated environmental damage (landfill sludge) is analysed, the main criteria for the identification of environmental damage for these pollutants are determined.
Ecological state of the water objects in Perm Krai and prevalence of parasitic disease among the population
Authors: Dvinskikh S A , Zujeva T V , Kitaev A B 
Published: September 2019

Abstract
Perm Krai is a region with a high level of parasitic disease, which depends on the presence of natural focal points of infection, water pollution and social conditions. The article analyses the role of ecological state of water bodies and social conditions on the basis of population survey. It is confirmed that the pollution of water bodies is not a determinant factor of the spread of helminthiasis among the population. Social factors come to the fore.
Seasonal variation of methane flux from Mozhaisk reservoir
Authors: Grechushnikova M G , Repina I A , Kazantsev V S , Artamonov A Yu , Lomov V A , Lomova D V , Kremenetskaya E R 
Published: September 2019

Abstract
The paper present the results of methane flux measuring from the surface of valley type reservoir with a long water residence time. The factors of its spatio-time variations are revealed. The results of calculation and measurements of diffusive flux are compared.
Up-regulation of endometrial oxytocin receptor is associated with the timing of luteolysis in heifers with two and three follicular waves†
Authors: Domingues Rafael R , Ginther O J , Gomez-León Victor E , Wiltbank Milo C 
Published: September 2019

Abstract
Initiation of luteolysis in ruminants is variable due to ill-defined mechanisms. Cycles of two follicular waves are shorter and have earlier luteolysis than three-wave cycles. This study validated a cytobrush technique for evaluating dynamics of endometrial gene expression and associated changes in mRNA with timing of luteolysis, based on circulating progesterone and ultrasound-determined changes in blood flow and volume of corpus luteum (CL). On day 8 (ovulation = day 0), Holstein heifers were randomized into two groups: cytobrush group (n = 9) had an endometrial sample collected every 48 h from day 8 until end of luteolysis (CL blood flow ≤ 20%) and control group was sampled only once either before (day 12; n = 4) or at the end of luteolysis (n = 5). Concentrations of progesterone, CL blood flow, CL volume, and the frequency of two and three-wave cycles were similar between groups. Endometrial mRNA for progesterone receptors and estradiol receptors 1 and 2 was greater on day 8 and decreased thereafter similarly in two and three-wave cycles. Oxytocin receptor mRNA increased earlier in two vs three-wave cycles (day 14 vs 18), and the increase was associated with the onset of luteolysis. In conclusion, the cytobrush technique allowed in vivo collection of multiple endometrial samples during the estrous cycle. Endometrial mRNA expression of steroid receptors did not explain the variability in timing of onset of luteolysis in heifers while the later onset of luteolysis in three-wave cycles was associated with later up-regulation of oxytocin receptor mRNA.
Emergency Department Visits After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis
Authors: Harris Andrew B. , Marrache Majd , Puvanesarajah Varun , Raad Micheal , Skolasky Richard L. , Njoku Dolores , Sponseller Paul D. , Jain Amit 
Published: September 2019

Background:
The incidence of emergency department (ED) visits after posterior spinal fusion (PSF) in adolescent idiopathic scoliosis (AIS) patients is not well known. We hypothesize that the majority of ED visits are related to constipation and pain issues, and are not for serious complications.

Methods:
Using a private insurance claims database, we identified AIS patients aged 10 to 21 years who underwent PSF from 2010 to 2015. Patients were excluded for diagnoses of neuromuscular or syndromic scoliosis. ED visits that occurred within the 6-month postoperative period were identified. The diagnoses present at these visits were pooled and analyzed, in addition to insurance payments associated with these visits. Significance was set at P=0.05.

Results:
A total of 5934 patients met inclusion criteria. Mean age was 14.4±2.2 years, and 75% of the patients were girls. A total of 577 (9.7%) patients had at least 1 ED visit in the 6-month postoperative period, whereas 92 (1.6%) had 2 ED visits and 19 (0.3%) had 3 or more ED visits. The median time to ED visits was 33 days after surgery. Independent risk factors for ED visits were: older age, and greater levels fused (P<0.05). The top 5 most common reasons for ED visits were: pain/back or musculoskeletal, constipation/GI issues, asthma/ respiratory issues, upper respiratory infection, and dehydration. Rates of ED visits were similar among the US geographic regions. Patients who had an ED visit had significantly higher total 6-month health care payments than those who did not (P<0.001).

Conclusions:
Approximately 10% of the patients had ≥1 ED visit in the 6-month period after PSF for AIS. A majority of the diagnoses at these ED visits were outpatient medical issues.

Level of Evidence:
Level III.
Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia
Authors: Zhang Xuesong , Zhou Dongmei , Ma Tengfei , Liu Qingquan 
Published: September 2019

BACKGROUND
5α-DHT can decrease the cell viability of the hair follicle stem cells (HFSCs) with CD34-positive and CD200-rich in bald scalp area of androgenic alopecia (AGA) patients and the apoptosis of HFSCs may be involved in the pathogenesis of AGA. The expression of Vascular endothelial growth factor (VEGF) turns to be weakened or disappeared in hair follicles of AGA patients.

OBJECTIVE
To investigate whether VEGF is involved in the apoptosis of HFSCs induced by 5α-DHT in the patients of AGA.

METHODS
By 5α-DHT, apoptosis of CD200-rich and CD34-positive HFSCs was induced and apoptotic rates up to 24 hours were assessed using flow cytometry. The expression grades of Bcl-2, Akt, caspase-3 and Bax were observed through Western blot analysis.

RESULTS
Vascular endothelial growth factor could cut 5α-DHT induced apoptosis down substantially in a concentration-dependent manner. The 5α-DHT induced decline in the rise of Bcl-2/Bax proportion and the increase in caspase-3 degrees were mostly reversed by using VEGF and the VEGF's anti-apoptotic actions were impeded through preventing the activation of phosphoinositide 3-kinase (PI3K)/Akt.

CONCLUSION
Vascular endothelial growth factor can protect CD200-rich and CD34-positive HFSCs from androgen induced apoptosis by means of the PI3K/Akt pathway.
Using Therapeutic Drug Monitoring and Pharmacovigilance to Overcome Some of the Challenges of Developing Medicinal Cannabis from Botanical Origins
Authors: Dryburgh Laura M. , Martin Jennifer H. 
Published: September 2019

Purpose:
Plants belonging to the genus Cannabis have been domesticated and used by humans for millennia. Thought to have originated from central Asia, cannabis has been harnessed for its nutritional, therapeutic, and psychoactive properties, and as a source of fiber (Office of Medicinal Cannabis. Analytical Monograph Cannabis Flos. Den Haag, The Netherlands: Office of Medicinal Cannabis; 2014). Human use of cannabis is not novel; however, its medicalization offers a new pharmacotherapeutic frontier.

Methods:
The authors recently reported a systematic review of the contaminants of cannabis (National Academies of Sciences Engineering, and Medicine. The health effects of cannabis and cannabinoids: the current state of evidence and recommendations for research. Washington, DC; 2017). This article draws on the research limitations identified by that review and examines a collection of the relevant literature to provide an appreciation of the current evidence base.

Results:
The review explores the current status of cannabis in medical use, the drug development aspects that apply when taking a plant through to pill development, and the roles that therapeutic drug monitoring and pharmacovigilance have to guide practice until the drug development information on medicinal cannabis preparations is complete.

Conclusions:
A surge of public and clinical interest in the possible therapeutic applications of constituent cannabinoids has potentiated global legislative and policy reform. However, our understanding of its properties, optimized use, and harmful effects remains incomplete (Therapeutic Goods Administration. Guidance for the use of medicinal cannabis in Australia In: Department of Health Department, editor. Woden ACT Australian Government 2017; Dryburgh LM, Bolan NS, Grof CP, Galettis P, Schneider J, Lucas CJ, et al. Cannabis contaminants: sources, distribution, human toxicity and pharmacologic effects. Brit J Clin Pharm. 2018;84(11):2468–2476). In particular, a comprehensive appreciation of its toxicity profile is lacking.
Mental health conditions diagnosed before bilateral oophorectomy: a population-based case-control study
Authors: Gazzuola Rocca Liliana , Smith Carin Y. , Bobo William V. , Grossardt Brandon R. , Stewart Elizabeth A. , Laughlin-Tommaso Shannon K. , Rocca Walter A. 
Published: September 2019

Abstract

Objective:
We studied eight mental health conditions diagnosed before bilateral oophorectomy performed for nonmalignant indications.

Methods:
We identified 1,653 premenopausal women who underwent bilateral oophorectomy for a nonmalignant indication in Olmsted County, Minnesota, during a 20-year period (1988-2007). Each woman was matched by age (±1 year) to one population-based control who had not undergone bilateral oophorectomy before the index date (age range: 21-49 years). Both cases and controls were identified using the records-linkage system of the Rochester Epidemiology Project (REP http://www.rochesterproject.org). For eight mental health conditions, we calculated odds ratios (ORs) and their 95% confidence intervals (95% CIs) adjusted for race, education, and income using conditional logistic regression.

Results:
Pre-existing mood disorders, anxiety disorders, and somatoform disorders were associated with increased risk of bilateral oophorectomy in overall analyses. These associations were also significant in women ≤45 years of age at index date. Personality disorders were associated with increased risk only in overall analyses and adjustment disorders only in women 46 to 49 years of age. Some of the associations were significantly different across strata by age at index date and by indication. There was also a linear trend of increasing adjusted ORs from 1.55 (95% CI 1.31-1.83) for one mental health condition to 2.19 (95% CI 1.40-3.41) for three or more conditions (trend P < 0.001).

Conclusions:
We identified several mental health conditions that were associated with bilateral oophorectomy for nonmalignant indications. Awareness of these associations may guide women and physicians in future decision-making and limit unindicated bilateral oophorectomies.

Video Summary:

http://links.lww.com/MENO/A458.
Education level and breast cancer incidence: a meta-analysis of cohort studies
Authors: Dong Jia-Yi , Qin Li-Qiang 
Published: September 2019

Abstract

Objective:
We aimed to examine the association between education level and breast cancer incidence by a meta-analysis of cohort studies.

Methods:
Relevant studies were identified by searching PubMed, Web of Science, and Scopus databases on June 10, 2018. Reference lists from the obtained articles were also reviewed. We included cohort studies reporting relative risks with 95% CIs for the association between education level and breast cancer incidence. Either a fixed- or random-effects model was used to calculate the pooled risk estimates.

Results:
We identified 18 cohort studies with more than 10 million women. Compared with women with a lower education level, women with a higher education level had a significantly higher risk of developing breast cancer (pooled relative risk 1.22 [95% CI, 1.14-1.30]). The results did not differ by study area or reference group. The association remained in studies that adjusted for age at first birth and parity, but was attenuated and no longer significant when the analysis was restricted to studies that adjusted for alcohol use, to studies that adjusted for age at menopause, or to studies that adjusted for hormone therapy.

Conclusions:
A higher education level may be associated with an increased risk of developing breast cancer, in which alcohol use, age at menopause, and hormone therapy may, at least partially, play a mediating role.
A Systematic Review and Meta-analysis on PTSD Following TBI Among Military/Veteran and Civilian Populations
Authors: Loignon Alexandra , Ouellet Marie-Christine , Belleville Geneviève 
Published: September 2019

Objectives:
To determine whether persons with traumatic brain injury (TBI) are at greater risk of developing posttraumatic stress disorder (PTSD) than other trauma-exposed populations without TBI, and whether this risk is even greater in military/veteran settings than in civilian settings.

Design:
A systematic review and meta-analysis was conducted in 7 databases. Reference lists from the 33 identified studies and other relevant reviews were also searched.

Results:
The pooled PTSD proportion reached 27% (95% confidence interval = 21.8-33.1) in groups with TBI, which was 2.68 times greater than the observed 11% (95% confidence interval = 8.0-15.0) in groups without TBI. PTSD after TBI was more frequently observed in military samples than in civilians (37% vs 16%). Military and civilian samples were respectively 4.18 and 1.26 times more inclined to have a diagnosis of PTSD after TBI than when there was no TBI. The proportion of PTSD after TBI was concurrently attributable to the methods of the included studies (objectives focused on PTSD diagnosis, type of comparison group) and to characteristics specific to the military setting (country, sex, blast injuries).

Conclusions:
TBI diagnosis and military setting represent greater risks for PTSD. The dual diagnosis of TBI and PTSD requires interdisciplinary collaboration, as physical and psychological traumas are closely intertwined.
Pragmatic Language Comprehension After Pediatric Traumatic Brain Injury: A Scoping Review
Authors: Deighton Stephanie , Ju Narae , Graham Susan A. , Yeates Keith Owen 
Published: September 2019

Objective:
This scoping review aims to examine the literature pertaining to pragmatic language comprehension in pediatric traumatic brain injury (TBI), in order to summarize the current evidence and to identify areas for further research.

Methods:
We searched MEDLINE Ovid and PsycINFO Ovid using search terms to identify all articles that examined pragmatic language comprehension in children and adolescents with TBI published until November 2017.

Results:
A total of 13 articles met our inclusion criteria. The studies included examined a number of pragmatic domains including knowledge-based and pragmatic inferences, detection and judgment of ambiguous sentences, comprehension of humor, understanding of figurative language (eg, metaphors and idioms), and comprehension of irony and deceptive praise.

Conclusion:
The research suggests that children and adolescents with TBI, as compared with healthy or orthopedically injured controls, display deficits in comprehension of pragmatic language. Children with severe TBI demonstrate more widespread deficits in pragmatic comprehension abilities, whereas children with mild TBI show relatively intact pragmatic comprehension. Limitations and gaps identified in the literature warrant further research in this area.
Evaluation of a Brief, Skill-Building, Supportive, and Educational Intervention for Couples After Brain Injury
Authors: Kreutzer Jeffrey S. , Marwitz Jennifer H. , Sima Adam P. , Graham Kristin M. , Hsu Nancy H. , Mills Ana , Lukow Herman R. 
Published: September 2019

Objective:
To examine the effectiveness of an intervention (Therapeutic Couples Intervention, TCI) designed to improve relationship quality for couples after acquired brain injury.

Setting:
Outpatient brain injury rehabilitation center.

Participants:
Persons with brain injury (n = 75) and their intimate partners (n = 75).

Design:
Two-arm parallel, randomized, controlled trial with wait-listed control.

Methods:
Composed of 5 to 6 2-hour sessions, the TCI is a manualized, treatment program designed to enhance relationship quality by addressing issues and concerns most often identified by persons with brain injury and their partners.

Main Measure:
Revised Dyadic Adjustment Scale completed by the persons with brain injury and their partners.

Results:
Persons with brain injury and their partners in the treatment group showed an improvement in relationship quality, both compared with their own baseline values and the control group.

Conclusions:
Investigation provided evidence that a curriculum-based education, skill-building, and supportive intervention can benefit couples for up to 3 months after treatment. Additional research is needed to ascertain the long-term benefits of intervention and the efficacy of alternative delivery methods (eg, Internet, telephone, and group).
Multidisciplinary Concussion Management: A Model for Outpatient Concussion Management in the Acute and Post-Acute Settings
Authors: Bailey Christopher , Meyer Jessica , Briskin Susannah , Tangen Christopher , Hoffer S. Alan , Dundr Jason , Brennan Bethany , Smith Paul 
Published: September 2019

Objective:
To describe a model of multidisciplinary concussion management and explore management methods in the acute and post-acute settings.

Setting:
A multidisciplinary concussion management program within a large health system.

Participants:
Patients with sports and non–sports-related concussions aged 14 to 18 years with persisting concussion symptoms at 4 weeks postinjury or beyond.

Design:
Pilot randomized controlled trial comparing a subsymptom threshold exercise program with standard-of-care treatment in the post-acute setting.

Main Measures:
Beck Depression Inventory-II and the Post-Concussion Scale-Revised.

Results:
Across groups, 60% improvement in concussion symptoms was noted. After removing the influence of depression, the intervention showed a large effect on symptom reduction, with participants in the intervention group improving more than those in the control group. There was no difference in response to the intervention by the sports and nonsports groups.

Conclusion:
Results demonstrate that exercise intervention is effective in reducing symptoms in adolescents with persisting symptoms. The finding that participants in the control group who underwent education, light activity, and sophisticated monitoring still had meaningful recovery supports the utility of active engagement in a multidisciplinary management program. Finally, depression had a clinically meaningful effect on recovery, highlighting the need for targeted intervention of noninjury factors relevant to persisting symptoms.
N-Acetyl-Aspartate in the Dorsolateral Prefrontal Cortex Long After Concussion in Youth
Authors: MacMaster Frank P. , McLellan Quinn , Harris Ashley D. , Virani Shane , Barlow Karen M. , Langevin Lisa Marie , Yeates Keith Owen , Brooks Brian L. 
Published: September 2019

Objective:
Despite increasing interest in the neurobiological effects of concussion in youth, a paucity of information is available regarding outcomes long after injury. The objective of this study was to determine the association between a history of concussion and the putative neuronal marker N-acetyl-aspartate (NAA) in the dorsolateral prefrontal cortex (DLPFC) in youth.

Setting:
Outpatient clinic in a children's hospital.

Participants:
Youth with concussion (N = 35, mean = 2.63, SD = 1.07 years postinjury) and youth with a nonconcussive orthopedic injury (N = 17) participated.

Design:
A cross-sectional proton magnetic resonance spectroscopy (1H-MRS) study.

Main Measures:
The primary outcome measure was NAA concentration in the right and left DLPFCs.

Results:
We observed lower levels of NAA in the right DLPFC in youth with past concussion (F = 3.31, df = 4,51, P = .018) than in orthopedic controls but not in the left DLPFC (F = 2.04, df = 4,51, P = .105). The effect of lower NAA concentrations in the right DLPFC was primarily driven by youth with a single prior concussion versus those with multiple concussions. NAA in the left DLPFC, but not in right DLPFC, was associated with worse emotional symptoms in youth with concussion.

Conclusion:
The presence of lower levels of DLPFC NAA suggests potential association of concussion in youth, although further investigation is needed, given that the result is driven by those with a single (and not multiple) concussion. Exploration of applying MRS in other brain regions is also warranted.