bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Potential of Game-Based Digital Biomarkers for Modeling Mental Health
Authors: Mandryk Regan Lee , Birk Max Valentin 
Published: March 2019

BackgroundAssessment for mental health is performed by experts using interview techniques, questionnaires, and test batteries and following standardized manuals; however, there would be myriad benefits if behavioral correlates could predict mental health and be used for population screening or prevalence estimations. A variety of digital sources of data (eg, online search data and social media posts) have been previously proposed as candidates for digital biomarkers in the context of mental health. Playing games on computers, gaming consoles, or mobile devices (ie, digital gaming) has become a leading leisure activity of choice and yields rich data from a variety of sources.ObjectiveIn this paper, we argue that game-based data from commercial off-the-shelf games have the potential to be used as a digital biomarker to assess and model mental health and health decline. Although there is great potential in games developed specifically for mental health assessment (eg, Sea Hero Quest), we focus on data gathered “in-the-wild” from playing commercial off-the-shelf games designed primarily for entertainment.MethodsWe argue that the activity traces left behind by natural interactions with digital games can be modeled using computational approaches for big data. To support our argument, we present an investigation of existing data sources, a categorization of observable traits from game data, and examples of potentially useful game-based digital biomarkers derived from activity traces.ResultsOur investigation reveals different types of data that are generated from play and the sources from which these data can be accessed. Based on these insights, we describe five categories of digital biomarkers that can be derived from game-based data, including behavior, cognitive performance, motor performance, social behavior, and affect. For each type of biomarker, we describe the data type, the game-based sources from which it can be derived, its importance for mental health modeling, and any existing statistical associations with mental health that have been demonstrated in prior work. We end with a discussion on the limitations and potential of data from commercial off-the-shelf games for use as a digital biomarker of mental health.ConclusionsWhen people play commercial digital games, they produce significant volumes of high-resolution data that are not only related to play frequency, but also include performance data reflecting low-level cognitive and motor processing; text-based data that are indicative of the affective state; social data that reveal networks of relationships; content choice data that imply preferred genres; and contextual data that divulge where, when, and with whom the players are playing. These data provide a source for digital biomarkers that may indicate mental health. Produced by engaged human behavior, game data have the potential to be leveraged for population screening or prevalence estimations, leading to at-scale, nonintrusive assessment of mental health.
Práctica pedagógica en la formación para el cuidado de enfermería
Authors: Tejada S. , Ramirez E.J. , Díaz R.J. , Huyhua S.C. 
Published: March 2019

Objetivo: Explorar la práctica pedagógica docente en la formación para el cuidado de enfermería en la Universidad Nacional Toribio Rodriguez de Mendoza del Amazonas.
Material y método: Estudio cualitativo, exploratorio, descriptivo: la muestra la conformaron 21 informantes. La recolección de información fue por medio de entrevista semi estructurada. El análisis siguió un proceso de codificación abierta, axial y selectiva hasta obtener categorías emergentes.
Resultados: Se identificaron las siguientes categorías: I) Convivencia y relaciones de cuidado/descuido en la formación de enfermería; II) (Des)articulación teórico- práctica en la enseñanza/aprendizaje del cuidado de enfermería: hacia la integración docente-asistente; III) Complementariedad docente/estudiante para la construcción de conocimiento y estrategias didácticas.
Conclusiones: La pedagogía para el cuidado de enfermería se evidencia en un espacio de cuidado/descuido, demandan integración docencia-asistencia y se motivan para el fortalecimiento de competencias pedagógico didácticas, a través del aprendizaje basado en problemas, casos hipotéticos, laboratorios vivenciales y sociodramas e incluir como ejes trasversales el cuidado y la investigación.
Atención de Enfermería durante el postoperatorio a paciente sometido a clipaje de aneurisma por ruptura
Authors: Castillo-Garcia J.K. , García-Rosas E. , Cheverría-Rivera S. 
Published: March 2019

Introducción: Es reconocido que el personal de enfermería es quien tiene mayor interacción con el paciente, por lo que se ve obligado a contar con conocimientos y experiencia suficiente que permita identificar y atender las necesidades de individuos que sufren de enfermedad cerebrovascular. Esta condición de salud puede ser secundaria a la ruptura de un aneurisma, lo que conduce al paciente a un estado crítico; además, puede traducirse en riesgo para el equilibrio financiero de la familia y el Sistema Sanitario.
Métodos: Se desarrollaron las etapas del proceso de cuidado de enfermería centradas en una situación real de la práctica clínica durante el periodo postoperatorio de una paciente sometida a clipaje de aneurisma. Se utilizó el modelo de patrones funcionales de Marjory Gordon para la recolección de los datos; además de la taxonomía NANDA-NIC-NOC.
Resultados: Se presentan los planes de cuidado en los que se centró la intervención de enfermería en la paciente valorada. Así como la evaluación del proceso en las dimensiones de estructura, proceso y resultado.
Discusión/conclusiones: El EVC secundario a ruptura de aneurisma cerebral es una situación grave y devastadora para la familia y el sistema sanitario. Por tanto, una adecuada atención de enfermería a este problema es de la mayor importancia.
STUDI PERENCANAAN NORMALISASI SUNGAI KALI SONO DI KOTA MADIUN
Authors: Heremba Sribanun Laila Sa’adah 
Published: March 2019

PT. Bank Papua Cab. Fakfak Kali river is located in Madiun with 27,56 km2 large DAS Kali Sono. When the rain come,itcaused flood there. It is needed to solve the problem in which the capability to handle the waterdebitis low. The concept of planning and reconstructing system is flood handling system witharranging dike construction in all the left and right bank of the river.Nakayasu method is one method can be used to know the water debit in each 5 years based onthe arranged rainfall rate. The maximum debit from this accumulation is (Qtr 5) = 87.623 m/det2, soit is needed to reconstructing the river floor.After analize the water profil by using Standart FaseMethod by devide the flow into 58patok. The flow wide is plannedto get the fix profil. Dimensionwith the bank 1:1 is planned to build a dike with urugan ground. After controll the rembesan andaccumulate the stability, it shows savety dake result. From the savety wall analization with theworking force dan controlled to the rolle, movement, and ground pushment that happened to thesavety wall can fulfill the savety point which is appropriate with the legal savety.Keywords: River dimension arranging, dike
ANÁLISE DOS PROCESSOS LOGÍSTICOS DE UMA MICROEMPRESA: ÊNFASE NO TRANSPORTE
Authors: Silva Ariane Barbosa , Silva Alan Jeferson de Oliveira da , Suzano Marcio Alves , Murta Aurélio Lamare Soares 
Published: March 2019

Este artigo buscou analisar os processos logísticos de um quiosque na praia da Barra da Tijuca. A pesquisa foi impulsionada pela falta de controle e gerenciamento das atividades logísticas, principalmente em relação ao transporte. Este estudo teve como objetivo estudar e analisar o processo logístico de transporte, considerando a sua relação com os aspectos de armazenagem e processamento de pedido. A metodologia utilizada foi de natureza exploratória com apresentação dos resultados de forma quantitativa. O primeiro passo foi definir a delimitação do estudo e elaborar a revisão bibliográfica, o segundo passo consistiu no levantamento de dados e informações através da pesquisa de campo, em seguida os dados foram analisados e tratados e, por último, os resultados foram apresentados. Com esse trabalho foi possível identificar e calcular os principais custos atrelados ao transporte, definir o melhor roteiro para o serviço, além de indicar possíveis melhorias para otimização do tempo e redução dos custos.
Optimalisasi Gula Cair dan pH Medium untuk Fermentasi Alkohol dari Jus Curucuma xanthorihiza
Authors: Atmodjo Kianto 
Published: March 2019

Gula cair suatu produk baru dari gula yang tersusun dari fruktosa, glukosa dan disakarida dianggap lebih baik daripada gula kristal. Penelitian ini bertujuan untuk mengetahui konsentrasi gula cair dan pH medium yang digunakan dalam fermentasi sari temulawak (Curcuma xantorhiza Raoxb) oleh Saccharomyces cerevisiae untuk memproduksi alkohol. Satu kg temulawak kering dihancurkan ditambah air sebanyak 8 liter, ditambahkan 250 g kecambah kacang hijau, direbus selama 30 menit, lalu didinginkan kemudian direbus lagi tiga kali rebusan disaring lalu diambil airnya kemudian dimasukkan ke dalam botol fermentasi sebanyak 300 ml kemudian ditambahkan gula cair sehingga diperoleh variasi 0,15%, 30%, 45%, 60% dan 75%. Medium sari temulawak ini diatur pH nya menjadi 4, 4,5, 5,0, 5,5 dan 6. Selanjutnya 1 g bibit S. cerevisiae ditambahkan pada tiap botol fermentasi lalu ditutup. Fermentasi berlangsung pada suhu kamar. Parameter penelitian berupa total sel, pH dan gula reduksi yang diukur tiap sehari sebanyak tiga kali, dan kadar alkohol setelah satu bulan fermentasi. Hasil menunjukkan tidak adanya hubungan yang signifikan antara peningkatan kadar gula dan perbedaan pH medium terhadap total sel, perubahan pH dan kadar gula. Namun ada hubungan yang nyata antara kenaikan kadar gula medium dengan alkohol yang dihasilkan. Efisiensi konversi gula menjadi alkohol tertinggi di atas 3% terjadi pada fermentasi pada konsentrasi gula 45%. Kadar alkohol tertinggi dihasilkan pada pH medium awal 5.
PARA HARIMAU YANG MENOLAK PUNAH: ESTETIKA DOKUMENTER TELEVISI DI ERA PASCAREFORMASI
Authors: Rozi Romdhi Fatkhur , Hasan Renta Vulkanita 
Published: March 2019

ABSTRAKPara Harimau Yang Menolak Punah(Imanda Dea Sabiella dan Edho Cahya Kusuma, 2013) merupakan judul dokumenter televisi produksi Eagle Institutedengan ciri filmis berupa paduan antara gambar dan tuturan (wawancara). Dokumenter ini merupakan objek material yang menarik untuk diteliti dalam konteks kontinuitas dan perubahan estetika, selama era pasca reformasi dengan zaman Orde Baru sebagai pembanding. Jika pada masa orde baru, kampanye pelestarian lingkungan melalui media dokumenter notabene diproduksi oleh pemerintah melalui estetika sinematik yang bersifat propagandis, maka saat ini dokumenter produksi Eagle Institutejustru menggunakan estetika sinematik yang kritis sebagai konter bagi pemerintah. Fakta dan fiksi (faksi) menjadi istilah yang digunakan dalam penelitian ini sebagai bentuk kontinuitas dan perubahan dokumenter televisi Indonesia. Alasan pemilihan istilah ini adalah dunia fenomenal dalam banyak kasus, seperti yang terlihat dalam dokumenter, seakan berbeda dari "dunia nyata", meskipun dalam kenyataannya rekaman itu berasal dari “dunia nyata/realitas”. Penelitian ini menggunakan pendekatan film kognitif untuk mengamati sejauh mana Faksi beroperasi sebagai media kritik yang secara estetis merangkai dokumenter tersebut. Struktur mental digunakan untuk menjelaskan Faksi melalui petunjuk filmis hingga diperoleh kesimpulan tentang kritik yang ingin disampaikan melalui dokumenter. ABSTRACTPara Harimau Yang Menolak Punah (Imanda Dea Sabiella dan Edho Cahya Kusuma, 2013) is the title of a television documentary produced by Eagle Institute. The documentary has characters that specifically contains of expository shots. This documentary is an interesting material object to be examined in the context of continuity and aesthetic change, during the post-reform era with the New Order era as a comparison. During the new order era, environmental conservation campaigns through documentary media were produced by the government through propagandist cinematic aesthetics. Whereas, the post-reform documentary produced by Eagle Institute actually uses a critical cinematic aesthetic as a counter for the government. Fact and fiction (faction) became the term used in this study as a form of continuity and change of Indonesia documentary. The reason for choosing this term is the phenomenal world in many cases, as seen in the documentary, as though it were different from the "real world", even though in reality it came from "the real world". This study uses a cognitive film approach to observe the extent to which the Faction operates as a criticism medium which aesthetically assembles the documentary. The mental structure is used to explain the Faction through filmic clues to the conclusion of the criticism that the documentary wishes to convey.
Effect of Different Seed Water Content and Storage Duration towards Seed Viability of Local Genotype Brown Rice Daro Merah
Authors: Dwipa Indra , Muhsanati Muhsanati 
Published: March 2019

Most of rice seeds experience after ripening problem which then result in seed dormancy. This kind of dormancy could be broken through various types of treatments, including storaging in dry place for certain period. This study was aimed to evaluate the combination between seed water content and storage duration to induce the seed germination of local genotype brown rice, Daro Merah. Various levels of seed water content (6-10, 11-15, 16-20 and 21-25 %) and storage duration (2, 4, 6 and 8 weeks) were evaluated to identify its effect on Daro Merah seed germination. Data were analyzed using two-way analysis of variance where significance were further proceeded using Duncan’s New Multiple Range Test with a p>0.05. The results showed that seed germination of Daro Merah reached 95 % at five days after seeding when the seed water content was maintained at 6-10% and stored for 8 weeks. After 14 days, the germination reached 99 % and most of the seeds showed some shoots emerged from the soil.
Keywords: Brown rice, germination, seed water content, storage duration, Daro Merah
The Effect of Pollination Models on Yield of Red Pitaya (Hylocereus polyrhizus)
Authors: Renfiyeni Renfiyeni 
Published: March 2019

Red pitaya is getting more popular in Indonesia recently as one of high antioxidant sources with a promising economic value. However, the production of this CAM plant is restricted by low success percentage of its natural pollination and self incompatibility problems. Therefore, artificial pollination is required to overcome these problems and increase its yield. This study was aimed to evaluate the effect of pollination models towards the yield of red pitaya. This study was conducted using randomized block design with three pollination models applied into nine groups. Pollination models used were open pollination (P1), hand-self-pollination (P2) and hand-cross pollination (P3). Several floral-related parameters, including the elongation of flower bud, diameter of blooming flower, length of stigma, number and length of anthers, were assessed. Effect of different pollination models was also observed through some yield-related parameters, such as fruit weight, fruit diameter, fruit length, harvesting age and number of fruit sets. This study revealed that hand cross pollination produced the best yield performance showing 541.1 gram of fruit with 11.5 in length and 8.66 cm in diameter. Harvesting age and number of fruit sets showed no significant difference among those three pollination models.
Keywords: Pollination, red pitaya, yields, fruits, flowers
Isolation of Cellulose Degradation Bacteria (CDB) from acid soil as a potential candidate of organic waste degradation
Authors: Samah Eri 
Published: March 2019

Background: The study aimed to obtain CDB with high degraded activities, determined growth curve, protein content, and cellulase maximum activity (exoglucanase and endoglucanase). Method: The cellulose activity calculated according to Miller (1959), protein content was measured by Bradford method with bovine serum albumin (BSA) as a standardize protein. Result: Six isolates of CDB were found as potential degradation of organic waste (Km25, Sr75, Jm, U6, G8, and Km13). Growth curve, protein level, and protein maximum activity occurred on day-3. The largest diameter of clear zone of six isolates was Km25, Sr75, Jm, U6, G8, and Km13 (3.32, 3.31, 2.41, 2.36, 2.19, and 2.04 mm, respectively). Endoglucanase and exoglucanase maximum activity were 0.011-0.402 IU/mL and 0.0028-0.155 IU/mL, respectively. Conclusion: Six isolates showed high activities of cellulase with diameter of clear zone ≥ 2 cm (Km25, Sr75, Jm, U6, G8, and Km13). Growth maximum curve was on day-3. Highest endo- and exoglucanase activities were on day-3 (0.402 IU/mL and 0.155 IU/mL, respectively) in Jm isolate.
Keywords: Identification, degradation, clear zones, cellulase.
Infecções relacionadas à assistência à saúde em recém-nascidos de alto risco: perfil de resistência dos bacilos Gram negativos
Authors: Modesto Esther Nicoli , Brito Denise Von Dolinger de 
Published: March 2019

Introdução: Infecções Relacionadas à Assistência à Saúde (IRAS) são problemas importantes dentro de uma Unidade de Terapia Intensiva Neonatal (UTIN), onde tanto fatores ambientais quanto intrínsecos do Recém-Nascido (RN) contribuem para a incidência das infecções. IRAS provocadas por bacilos Gram negativos apresentam relevância clínica devido à maior gravidade dos casos e à maior resistência destes patógenos aos antimicrobianos. Objetivo: Objetivou-se verificar a incidência de IRAS por bacilos Gram negativos multirresistentes, descrever os microrganismos identificados nas culturas laboratoriais e avaliar o perfil de resistência aos antimicrobianos. Metodologia: Foi realizado um estudo retrospectivo, do tipo caso-controle a partir da coleta de dados dos prontuários de 804 RN que estiveram internados na UTIN de um hospital terciário entre janeiro de 2010 e dezembro de 2012. Resultados: Os principais fatores de risco para IRAS: peso de nascimento entre 750g e 1500g e maior que 2500g, idade gestacional entre 26 e 30 semanas, tempo de internação maior que 8 dias, uso de cateter venoso central, uso de ventilação mecânica e nutrição parenteral. A IRAS mais frequente foi a Infecção da Corrente Sanguínea com Confirmação Laboratorial, e dentre os bacilos Gram negativos, a Klebsiella pneumoniae foi a mais frequente. Conclusão: O estudo atendeu aos objetivos propostos e mostrou a importância das ações de vigilância, prevenção e controle das IRAS nas unidades neonatais, reduzindo a ocorrência de agravos à saúde do RN de alto risco, contribuindo para a diminuição dos índices de morbi-mortalidade e promovendo a melhoria da qualidade da assistência no período neonatal.
Análise da qualidade das prescrições médicas em Montes Claros - Minas Gerais
Authors: Murta Inah Araújo de Almeida , Bastos Camila Bacelar , Lacerda Leidiane Vilasboas , Rocha Emanuelly Durães , Gomes Iara Lafetá , França Dorothéa Schmidt 
Published: March 2019

Introdução: A prescrição médica é a forma de informação e orientação e a falha nesta pode gerar dúvidas e prejudicar a saúde do paciente. Metodologia: O presente estudo avaliou o perfil de 589 receituários médicos, durante um período de 06 meses, em duas drogarias em Montes Claros - MG, observando principalmente a legalidade dos mesmos. Foram avaliadas onze variáveis foram: identificação do prescritor, identificação do paciente, posologia, tipo de receituário, quantidade de medicamentos por receita, intervalo das doses, orientações, assinatura e carimbo médicos. A coleta foi realizada pelo sistema de amostragem aleatória simples, as mesmas foram submetidas a análise e comparadas com a literatura que versa sobre o tema. Resultados: Nas 510 receitas consideradas legais, 504 (98,8%) continham assinatura do prescritor, 496 (97,2%), número de inscrição no CRM e 399 (78,2%) o endereço. Em relação aos dados do paciente, 509 (99,8%) apresentaram o nome e apenas 09 (1,76%) o endereço. Conclusão: É relevante que sejam estabelecidas estratégias que visem à oferta de orientações considerando o nível de entendimento dos usuários individualmente, o que pode ser atingido com a criação do Serviço de Atenção Farmacêutica e educação continuada de médicos.
Efficacy and Safety of Apremilast in Patients With Moderate to Severe Plaque Psoriasis of the Scalp: Results of a Phase 3, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study
Authors: Van Voorhees Abby , Stein Gold Linda , Lebwohl Mark , Al. Et 
Published: March 2019

Abstract not available. Disclosures: Study sponsored by Celgene.
Secukinumab Is Associated With Improvements in Real-World Effectiveness Outcomes Through 12 Months of Follow-Up in Patients With Plaque Psoriasis: Analysis of US Dermatology Electronic Medical Records
Authors: Yamauchi Paul , Chen Chi-Chang , Ding Yao , Al. Et 
Published: March 2019

Abstract not available. Disclosures: Study sponsored by Novartis.
Caffeine in the Treatment of Atopic Dermatitis and Psoriasis: A Review
Authors: Alashqar Mais Bassam 
Published: March 2019

Atopic dermatitis (AD) and psoriasis are inflammatory skin diseases. AD is characterized by immune dysregulation and barrier impairment, while psoriasis is by immune dysfunction and resultant keratinocyte hyper-proliferation. Caffeine has shown effective in ameliorating the symptoms of both diseases, but it is not conclusive through which pathways. The aim of this study was to provide a detailed discussion of available work on this topic, as well as known modes of action of caffeine that are relevant to these two conditions. After an extensive review of the literature, we found that both diseases have decreased intracellular cyclic adenosine monophosphate (cAMP) levels in cutaneous leukocytes, so it is very likely that being a methylxanthine, and hence a phosphodiesterase (PDE) inhibitor, caffeine raises intracellular cAMP levels, which suppresses inflammatory pathways and potentiates anti-inflammatory ones. Moreover, caffeine is known to be an ATR (ataxia-telangiectasia mutated) kinase and an ATM (ATM- and Rad3-Related) kinase inhibitor, which promotes prompt apoptosis of damaged cells. It was also found to have anti-necrotic effects in reactive oxygen species (ROS)-damaged cells. These pro-apoptotic and anti-necrotic properties may also be reducing the inflammation. Finally, caffeine's metabolites have shown antioxidising effects against ROS, which certainly would reduce inflammation caused by lipid peroxidation, DNA damage and organelle destruction. We find that caffeine acts in a number of ways to improve symptoms of inflammation and that it is an effective adjunct to therapy in AD and psoriasis.
Assessing Patient Satisfaction With Hydrogen Peroxide Topical Solution, 40% (w/w) Treatment of Seborrheic Keratoses on the Face, Neck, and Décolletage: Objectives and Design of the Phase 4, Open-Label SK-FAN Study
Authors: Dubois Janet , Grande Kimberly , Schnyder Judith , Al. Et 
Published: March 2019

Abstract not available. Disclosures: Study sponsored by Aclaris.