bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scientific Goals and In-orbit Performance of the High-energy Particle Detector on Board the CSES
Authors: Picozza P. , Battiston R. , Ambrosi G. , Bartocci S. , Basara L. , Burger W. J. , Campana D. , Carfora L. , Casolino M. , Castellini G. , Cipollone P. , Conti L. , Contin A. , De Donato C. , De Santis C. , Follega F. M. , Guandalini C. , Ionica M. , Iuppa R. , Laurenti G. , Lazzizzera I. , Lolli M. , Manea C. , Marcelli L. , Martucci M. , Masciantonio G. , Mergé M. , Osteria G. , Pacini L. , Palma F. , Palmonari F. , Panico B. , Parmentier A. , Patrizii L. , Perfetto F. , Piersanti M. , Pozzato M. , Puel M. , Rashevskaya I. , Ricci E. , Ricci M. , Ricciarini S. , Scotti V. , Sotgiu A. , Sparvoli R. , Spataro B. , Vitale V. , Zuccon P. , Zoffoli S. 
Published: July 2019

Abstract
The China Seismo-Electromagnetic Satellite (CSES) aims to monitor electromagnetic, particle, and plasma perturbations in the iono-magnetosphere and inner Van Allen radiation belts originated by electromagnetic sources external and internal to the geomagnetic cavity, cosmic rays, and solar events. In particular, the objective of the space mission is to investigate lithosphere–atmosphere–ionosphere coupling mechanisms (including the effects of lightning, earthquakes, volcanoes, and artificial electromagnetic emissions) that induce perturbations of the top side of the ionosphere and lower boundary of the radiation belts. To this purpose, the mission has been conceived to take advantage of a multi-instrument payload comprising nine detectors for the measurement of electromagnetic field components, plasma parameters, and energetic particles, as well as X-ray flux. The Italian team participating in the CSES mission has built one of these devices, the High-Energy Particle Detector (HEPD), for high-precision observations of electrons, protons, and light nuclei. During its trip along the orbit, and thanks to the large set of detectors operated on board, CSES completely monitors the Earth, acting as an excellent instrument for space weather. The satellite was launched on 2018 February 2, with an expected life span of 5 yr. This article describes the CSES mission with a particular focus on the HEPD apparatus and its in-flight performance.
Déterminants du recours au répit pour les proches aidants de malades atteints de démence
Authors: Bannerot Frédéric , Leocadie Marie-Conception , Rothan-Tondeur Monique 
Published: July 2019

Introduction : L’évolution démographique et le vieillissement de la population concourent à l’augmentation des maladies d’Alzheimer ou apparentées. Encouragé par les politiques de santé, le maintien à domicile des patients souffrant de ces pathologies est souvent dépendant de la contribution de proches aidants. L’exigence de ce rôle peut fragiliser les personnes concernées et favoriser chez elles l’apparition d’un sentiment de fardeau nécessitant le recours à des périodes de répit. Étude ancillaire d’un programme de recherche mené sur l’agglomération de Genève, notre travail vise à caractériser les déterminants d’un recours aux dispositifs de répit pour les proches aidants de patients atteints de démence, Méthode : Recherche qualitative, menée par la méthode de focus groupes, auprès des proches aidants de patients atteints de démence. Trois focus groupes ont été menés, avec 12 participants dans les agglomérations de Genève (Suisse) et Rouen (France). Résultats : Notre étude relève la concomitance de l’évolution des troubles de la personne aidée et l’émergence d’un sentiment de fardeau chez l’aidant, lié à la durée et l’intensité de l’aide prodiguée. Nos résultats permettent de distinguer les déterminants d’un recours aux dispositifs de répit qui dépendent de l’aidant ou des institutions et d’en proposer une modélisation. Conclusion : Les dispositifs de répit doivent bénéficier d’une coordination et s’adapter aux exigences des bénéficiaires, en termes de format et de qualité, afin d’en faciliter le recours aux populations les plus fragiles et d’éviter qu’il ne soit trop tardif.
Persecución y re-significación de lo popular y femenino en el mercado de la salud en Chile y Argentina 1850‑1900
Authors: Durán Manuel 
Published: July 2019

Durante el siglo XIX en Chile y Argentina, se instituyó un discurso médico positivista, regulando los modelos de género y clase. Fortaleciendo un paradigma científico y masculino. Ya organizados gremial y académicamente, el sector médico patriarcal inició una depuración del “mercado de la salud”, oponiéndose al ejercicio popular y femenino de la salud: meicas, parteras y sanadores. Por otra parte el sector médico profesional constituyó una imagen de la “naturaleza femenina” en términos de inestabilidad física y psicológicamente, incompatible con el ejercicio de un oficio científico. Estos “imaginarios” se instalaron en la mentalidad colectiva, constituyendo un discurso naturalizado. En este contexto las primeras médicos debieron re-significar nuevos ámbitos de acción médica, bajo una “política de los cuidados”, generando nuevos discursos y disciplinas profesionales.
La trace écrite scolaire : un récit ?
Authors: Promonet Aurore 
Published: July 2019

L’écriture scolaire ordinairement et quotidiennement pratiquée en France est appelée trace écrite. Elle se constitue d’écrits variés que l’enseignant décide de faire archiver dans les cahiers, carnets des élèves. Ces écrits constituent un corpus scolaire varié, faiblement prescrit et peu étudié. Le cahier relève d’une tradition scolaire qui alimente une partie du patrimoine des musées de l’éducation. Ce support ne change guère au fil des années. On y lit l’activité scolaire, la vie de la classe et la réussite des élèves. Le cahier peut se constituer en récit de vie, en récit de parcours scolaire ; il peut surtout soutenir l’élève dans son développement personnel comme sujet didactique au sein des disciplines scolaires. Cet article propose de le montrer à partir d’analyse de journaux d’apprentissages produits en dernières années d’école élémentaire.
Aux marges de la fiction sérielle télévisuelle : sémio-pragmatique de la shortcom familiale
Authors: Delaporte Chloé 
Published: July 2019

Cet article examine la relation entretenue par le sous-genre de la shortcom familiale avec la fiction sérielle télévisuelle, à partir d’un cadre théorique qui n’a pas été pensé pour l’analyse des séries télévisées : la sémio-pragmatique. Alors que les shortcoms familiales Scènes de ménages (M6, 2009-), Nos chers voisins (TF1, 2012-2017) ou Parents mode d’emploi (France 2, 2013-) se présentent comme des formes fictionnelles, leur analyse sémio-pragmatique révèle une hybridité énonciative de nature à solliciter de la part des publics d’autres modes de lecture que la seule lecture fictionnalisante.
Instrument-Assisted Soft Tissue Mobilization: A Systematic Review and Effect-Size Analysis
Authors: Seffrin Cristina B. , Cattano Nicole M. , Reed Melissa A. , Gardiner-Shires Alison M. 
Published: July 2019

Objective
To determine the overall effectiveness of instrument-assisted soft tissue mobilization (IASTM) in improving range of motion (ROM), pain, strength, and patient-reported function in order to provide recommendations for use. We also sought to examine the influence of IASTM on injured and healthy participants, body part treated, and product used.

Data Sources
We searched the Academic Search Premier, Alt Healthwatch, CINAHL Complete, Cochrane Library, MEDLINE with full text, NLM PubMed, Physical Education Index, Physiotherapy Evidence Database (PEDro), SPORTDiscus with full text, and Web of Science databases for articles published from 1997 through 2016. The Boolean string advantEDGE OR astym OR graston OR iastm OR “instrument assist* soft tissue mobil*” OR “augment* soft tissue mobil*” OR “myofascial release” OR “instrument assist* massage” OR “augment* massage” OR “instrument assist* cross fiber massage” was used.

Study Selection
Included articles were randomized controlled trials that measured ROM, pain, strength, or patient-reported function and compared IASTM treatment with at least 1 other group.

Data Extraction
Thirteen articles met the inclusion criteria. Four independent reviewers assessed study quality using the PEDro and Centre for Evidence-Based Medicine scales. Twelve articles were included in the effect-size analysis.

Data Synthesis
The average PEDro score for studies of uninjured participants was 5.83 (range = 5 to 7) and that for studies of injured participants was 5.86 (range = 3 to 7). Large effect sizes were found in outcomes for ROM (uninjured participants), pain (injured participants), and patient-reported function (injured participants). The different IASTM tools used in these studies revealed similar effect sizes in the various outcomes.

Conclusions
The current literature provides support for IASTM in improving ROM in uninjured individuals as well as pain and patient-reported function (or both) in injured patients. More high-quality research involving a larger variety of patients and products is needed to further substantiate and allow for generalization of these findings.
The lexical representation of English verbs of action. Complex predicates and structures
Authors: Ojanguren López Ana Elvira 
Published: July 2019

<p>This article aims at proposing a lexical representation for a set of English verbs of action. The analysis is carried out on the grounds of Role and Reference Grammar (RRG) and includes aspects like <em>Aktionsart </em>type, macrorole and syntactic function assignment, linking, as well as nexus and juncture. Against this background, the meaning components of the verbs in question are analysed, in such a way that a logical structure based on a lexical representation is defined for each verbal class. Conclusions fall on both the descriptive and the theoretical side. From the descriptive point of view, <em>Fail </em>and <em>Try </em>verbs constitute a unified verbal class as regards their meaning components and grammatical behaviour and, thus, they are represented by means of a unified logical structure. Conversely, <em>Prevent </em>verbs and <em>Forbid </em>verbs require different logical structures that account for their divergent grammatical behaviour, corresponding to the Causative Activity and Causative Achievement <em>Aktionsart </em>types respectively. On the theoretical side, the logical structures of <em>End </em>verbs, <em>Fail </em>verbs, <em>Try </em>verbs and <em>Prevent </em>verbs stick to the canonical representations of RRG, while those of <em>Hinder </em>verbs and <em>Refrain </em>verbs require complex predicates and complex logical structures which allow to incorporate extra meaning components and to combine different <em>Aktionsart </em>types.</p>
Influence of Arctic stratospheric ozone on surface climate in CCMI models
Authors: Harari Ohad , Garfinkel Chaim I. , Ziskin Ziv Shlomi , Morgenstern Olaf , Zeng Guang , Tilmes Simone , Kinnison Douglas , Deushi Makoto , Jöckel Patrick , Pozzer Andrea , O'Connor Fiona M. , Davis Sean 
Published: July 2019

Abstract. The Northern Hemisphere and tropical circulation response to interannual variability in Arctic stratospheric ozone is analyzed in a set of the latest model simulations archived for the Chemistry-Climate Model Initiative (CCMI) project. All models simulate a connection between ozone variability and temperature/geopotential height in the lower stratosphere similar to that observed. A connection between Arctic ozone variability and polar cap surface air pressure is also found, but additional statistical analysis suggests that it is mediated by the dynamical variability that typically drives the anomalous ozone concentrations. While the CCMI models also show a connection between Arctic stratospheric ozone and the El Niño–Southern Oscillation (ENSO), with Arctic stratospheric ozone variability leading to ENSO variability 1 to 2 years later, this relationship in the models is much weaker than observed and is likely related to ENSO autocorrelation rather than any forced response to ozone. Overall, Arctic stratospheric ozone is related to lower stratospheric variability. Arctic stratospheric ozone may also influence the surface in both polar and tropical latitudes, though ozone is likely not the proximate cause of these impacts and these impacts can be masked by internal variability if data are only available for ∼40 years.
Book Review: Drew Dalton, The Ethics of Resistance: Tyranny of the Absolute (London, U.K.: Bloomsbury Academic, 2018), pp. 154.
Authors: Nethery IV H.A. 
Published: July 2019

A review of Drew Dalton, The Ethics of Resistance: Tyranny of the Absolute (London, U.K.: Bloomsbury Academic, 2018), pp. 154.
Characteristics of adhesion areas between the tissue expander and capsule in implant-based breast reconstruction
Authors: Lim Yoon Min , Park Kwang Hyun , Lee Dong Won , Lew Dae Hyun , Roh Tai Suk , Song Seung Yong 
Published: July 2019

Background The use of anatomic implants has improved the aesthetic results of breast surgery; however, implant malrotation is an uncommon, but serious complication of these procedures. Nevertheless, little research has explored implant adhesion. In this study, we investigated adhesion between the expander and the capsule.
Methods Seventy-nine cases of immediate breast reconstruction via two-stage implantbased reconstruction performed between September 2016 and November 2017 were evaluated. Mentor CPX4 expanders were used in 14 breasts, and Natrelle expanders in 65. We analyzed areas of adhesion on the surfaces of the tissue expanders when they were exchanged with permanent implants. We investigated whether adhesions occurred on the cephalic, caudal, anterior, and/or posterior surfaces of the expanders.
Results Total adhesion occurred in 18 cases, non-adhesion in 15 cases, and partial adhesion in 46 cases. Of the non-adhesion cases, 80% (n=12) were with Mentor CPX4 expanders, while 94.4% (n=17) of the total adhesion cases were with Natrelle expanders. Of the partial adhesion cases, 90.7% involved the anterior-cephalic surface. The type of tissue expander showed a statistically significant relationship with the number of attachments in both univariate and multivariate logistic regression analyses (P<0.001) and with total drainage only in the univariate analysis (P=0.015).
Conclusions We sought to identify the location(s) of adhesion after tissue expander insertion. The texture of the implant was a significant predictor of the success of adhesion, and partial adhesion was common. The anterior-cephalic surface showed the highest adhesion rate. Nevertheless, partial adhesion suffices to prevent unwanted rotation of the expander.
Clinical outcomes of a low-cost single-channel myoelectric-interface three-dimensional hand prosthesis
Authors: Ku Inhoe , Lee Gordon K. , Park Chan Yong , Lee Janghyuk , Jeong Euicheol 
Published: July 2019

Background Prosthetic hands with a myoelectric interface have recently received interest within the broader category of hand prostheses, but their high cost is a major barrier to use. Modern three-dimensional (3D) printing technology has enabled more widespread development and cost-effectiveness in the field of prostheses. The objective of the present study was to evaluate the clinical impact of a low-cost 3D-printed myoelectric-interface prosthetic hand on patients’ daily life.
Methods A prospective review of all upper-arm transradial amputation amputees who used 3D-printed myoelectric interface prostheses (Mark V) between January 2016 and August 2017 was conducted. The functional outcomes of prosthesis usage over a 3-month follow-up period were measured using a validated method (Orthotics Prosthetics User Survey–Upper Extremity Functional Status [OPUS-UEFS]). In addition, the correlation between the length of the amputated radius and changes in OPUS-UEFS scores was analyzed.
Results Ten patients were included in the study. After use of the 3D-printed myoelectric single electromyography channel prosthesis for 3 months, the average OPUS-UEFS score significantly increased from 45.50 to 60.10. The Spearman correlation coefficient (r) of the correlation between radius length and OPUS-UEFS at the 3rd month of prosthetic use was 0.815.
Conclusions This low-cost 3D-printed myoelectric-interface prosthetic hand with a single reliable myoelectrical signal shows the potential to positively impact amputees’ quality of life through daily usage. The emergence of a low-cost 3D-printed myoelectric prosthesis could lead to new market trends, with such a device gaining popularity via reduced production costs and increased market demand.
P5CS expression study in a new family with ALDH18A1‐associated hereditary spastic paraplegia SPG9
Authors: Magini Pamela , Marco‐Marin Clara , Escamilla‐Honrubia Juan M. , Martinelli Diego , Dionisi-Vici Carlo , Faravelli Francesca , Forzano Francesca , Seri Marco , Rubio Vicente , Panza Emanuele 
Published: July 2019

AbstractIn 2015–2016, we and others reported ALDH18A1 mutations causing dominant (SPG9A) or recessive (SPG9B) spastic paraplegia. In vitro production of the ALDH18A1 product, Δ1‐pyrroline‐5‐carboxylate synthetase (P5CS), appeared necessary for cracking SPG9 disease‐causing mechanisms. We now describe a baculovirus–insect cell system that yields mgs of pure human P5CS and that has proven highly valuable with two novel P5CS mutations reported here in new SPG9B patients. We conclude that both mutations are disease‐causing, that SPG9B associates with partial P5CS deficiency and that it is clinically more severe than SPG9A, as reflected in onset age, disability, cognitive status, growth, and dysmorphic traits.
Benchmarking to the Gold Standard: Hyaluronan‐Oxime Hydrogels Recapitulate Xenograft Models with In Vitro Breast Cancer Spheroid Culture
Authors: Baker Alexander E. G. , Bahlmann Laura C. , Tam Roger Y. , Liu Jeffrey C. , Ganesh Ahil N. , Mitrousis Nikolaos , Marcellus Richard , Spears Melanie , Bartlett John M. S. , Cescon David W. , Bader Gary D. , Shoichet Molly S. 
Published: July 2019

AbstractMany 3D in vitro models induce breast cancer spheroid formation; however, this alone does not recapitulate the complex in vivo phenotype. To effectively screen therapeutics, it is urgently needed to validate in vitro cancer spheroid models against the gold standard of xenografts. A new oxime‐crosslinked hyaluronan (HA) hydrogel is designed, manipulating gelation rate and mechanical properties to grow breast cancer spheroids in 3D. This HA‐oxime breast cancer model maintains the gene expression profile most similar to that of tumor xenografts based on a pan‐cancer gene expression profile (comprising 730 genes) of three different human breast cancer subtypes compared to Matrigel or conventional 2D culture. Differences in gene expression between breast cancer cultures in HA‐oxime versus Matrigel or 2D are confirmed for 12 canonical pathways by gene set variation analysis. Importantly, drug response is dependent on the culture method. Breast cancer cells respond better to the Rac inhibitor (EHT‐1864) and the PI3K inhibitor (AZD6482) when cultured in HA‐oxime versus Matrigel. This study demonstrates the superiority of an HA‐based hydrogel as a platform for in vitro breast cancer culture of both primary, patient‐derived cells and cell lines, and provides a hydrogel culture model that closely matches that in vivo.
Late‐Stage 18F‐Difluoromethyl Labeling of N‐Heteroaromatics with High Molar Activity for PET Imaging
Authors: Trump Laura , Lemos Agostinho , Lallemand Bénédicte , Pasau Patrick , Mercier Joël , Lemaire Christian , Luxen André , Genicot Christophe 
Published: July 2019

AbstractDespite a growing interest in CHF2 in medicinal chemistry, there is a lack of efficient methods for the insertion of CHF18F into druglike compounds. Herein described is a photoredox flow reaction for 18F‐difluoromethylation of N‐heteroaromatics that are widely used in medicinal chemistry. Following the two‐step synthesis for a new 18F‐difluoromethylation reagent, the photoredox reaction is completed within two minutes and proceeds by C−H activation, circumventing the need for pre‐functionalization of the substrate. The method is operationally simple and affords straightforward access to radiolabeled N‐heteroaromatics with high molar activity suitable for biological in vivo studies and clinical application.
Rational Design of Specific Recognition Molecules for Simultaneously Monitoring of Endogenous Polysulfide and Hydrogen Sulfide in the Mouse Brain
Authors: Dong Hui , Zhou Qi , Zhang Limin , Tian Yang 
Published: July 2019

AbstractA biosensor was created for the simultaneous monitoring of endogenous H2Sn and H2S in mouse brains and exploring their roles in activation of the TRPA1 channel under two types of brain disease models: ischemia and Alzheimer's disease (AD). Based on DFT calculations and electrochemical measurements, two probes, 3,4‐bis((2‐fluoro‐5‐nitrobenzoyl)oxy)‐benzoic acid (MPS‐1) and N‐(4‐(2,5‐dinitrophenoxy) phenyl)‐5‐(1, 2‐dithiolan‐3‐yl)pentanamide (MHS‐1), were synthesized for specific recognition of H2Sn and H2S. Through co‐assembly of the two probes at the mesoporous gold film with good anti‐biofouling ability and electrocatalytic activity, this microsensor showed high selectivity for H2Sn and H2S against potential biological interferences. The biosensor can simultaneously determine the concentration of H2Sn from 0.2 to 50 μm, as well as that of H2S from 0.2 to 40 μm. The expression of TRPA1 protein positively correlated with levels of H2Sn under both ischemia and AD.
Replacing Mg2+ by Fe2+ for RNA‐Cleaving DNAzymes
Authors: Moon Woohyun J. , Liu Juewen 
Published: July 2019

AbstractIt has been proposed that Mg2+ and Fe2+ are very similar in interacting with ribozymes and some protein‐based enzymes, but their activities with DNAzymes have yet to be studied. Here, the activity of Fe2+ as cofactor for a few RNA‐cleaving DNAzymes is investigated. 17E is a well‐studied DNAzyme that is active in the presence of many different divalent metal ions; it is highly active with Fe2+ with an apparent Kd of 29.7±2.3 μm and a kobs of 1.12±0.11 min−1 in the presence of 1 mm Fe2+ at pH 7.5. Fe2+ has 21‐fold higher activity than Mg2+. Six different DNAzymes are then tested, and only the DNAzymes active with Mg2+ (17E, 8–17, and E5) are active with Fe2+. Fe2+ has 25 and one‐ to twofold higher activity than Mg2+ for the 8–17 and E5 DNAzymes, respectively. In pH>7 buffer and in presence of air, 1 mm Fe2+ results in a nonspecific degradation of the DNA strand due to reactive oxygen species (ROS). Cleavage reactions in anoxic environment and antioxidant ascorbate can be used to overcome the effect of oxidation. The findings provide insights for potential DNAzyme catalysis in the early Earth, and they further support the similarity between Mg2+ and Fe2+ in enzyme catalysis.