bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bertram, Martin, Die Handschriften des Liber Clementinarum des Johannes de Imola (1404)
Authors: Bertram Martin 
Published: July 2019

Abstract

The manuscripts of the Liber Clementinarum of Johannes de Imola (1404). As the author of this contribution has already argued in other occasions, in this paper he would like to highlight once more the importance of manuscripts for research in the literature of late medieval canon law. Manuscript witnesses of canon law literature after 1234 have never been subject of systematic review. This offers an explanation for the fact that this period has been largely disregarded in modern research. The example, chosen for this paper, shows that in particular the makeup and the external features of the manuscripts provide insights which paradoxically may be more revealing than the text itself: The commentary on the Constitutiones Clementinae by the Bolognese doctor utriusque iuris Iohannes de Imola (ca. 1375-1436) is preserved in more than 30 manuscripts, which contain an amazing amount of information regarding dates, scribes, commissioners and owners; last but not least, these manuscripts were continued seamlessly by a series of early printed editions. Altogether, they offer a vivid picture of the making, the proliferation and the use of Iohannes's work.
Neuheuser, Hanns Peter, Vom utensilium zum insignium. Zur rechtlichen und ästhetischen Ordnung der spätmittelalterlichen Kanonikergewandung
Authors: Neuheuser Hanns Peter 
Published: July 2019

Abstract

From utensilium to insignium: The juridical and esthetic order of the canons' vestment. The paper deals with the inner structure of the institutes of secular canons and the regulations of their specific vestments. As the liturgical vestment set for celebrating mass (alb, stole, chasuble resp. dalmatic) and for the liturgy of the office of the hours in the choir (alb, surplice, cope) was common for the whole clergy, in the (high) middle ages tendencies were shown to establish elements as insignia of a canon, e.g. the material, form, colour and wearing of the often hooded almuce. Topics of the research are the medieval goals to further an image of unity of the institution, to underline the hierarchic function of a single canon, and at last to show, where is the ecclesiastical instance to establish a juridical rule.
Lauener, Michael, Schutz der Kirche und Stabilität des Staates durch Absenz von religiöser ,Seichtigkeit': die religionspolitischen Anschauungen von Jeremias Gotthelf und Georg Wilhelm Friedrich Hegel aus dem Geist der Versöhnung
Authors: Lauener Michael 
Published: July 2019

Abstract

Protection of the church and state stability through the absence of religious 'shallowness': views on religion-policy of Jeremias Gotthelf and Georg Wilhelm Friedrich Hegel out of a spirit of reconciliation. The article re-examines a thesis of Paul Baumgartner published in 1945: "Jeremias Gotthelf's, 'Zeitgeist and Bernergeist', A Study on Introduction and Interpretation", that if the Swiss writer and keen Hegel-opponent Jeremias Gotthelf had read any book of the philosopher Georg Wilhelm Friedrich Hegel, some of this would have received his recognition. Both Gotthelf and Hegel see the Reformation to be the cause of the emergence of a strong state. For Gotthelf, this marks the beginning of a process of strengthening the state at the expense of the church. Hegel, on the other hand, considers the modern state to be the reality of freedom, produced by the Christian 'religion of freedom' (Rph, §270 Z., p. 430). In contrast to Gotthelf, for whom only Christ can reconcile the state and religion, Hegel praises the French Revolution as "reconciliation of the divine with the world". For Gotthelf, the French Revolution was only a poor imitation of the process of spiritual and political liberation initiated by the Reformation, through which Christ reduced people to their original liberty. Nevertheless, both Gotthelf and Hegel want to protect the state and the church from falling apart, they reject organizational unity of state – religion – church in the sense of a theocracy, and demand the protection of church communities.
Partial Selfing Can Reduce Genetic Loads While Maintaining Diversity During Experimental Evolution
Authors: Chelo Ivo M , Afonso Bruno , Carvalho Sara , Theologidis Ioannis , Goy Christine , Pino-Querido Ania , Proulx Stephen R , Teotónio Henrique 
Published: July 2019

AbstractPartial selfing, whereby self- and cross- fertilization occur in populations at intermediate frequencies, is generally thought to be evolutionarily unstable. Yet, it is found in natural populations. This could be explained if populations with partial selfing are able to reduce genetic loads and the possibility for inbreeding depression while keeping genetic diversity that may be important for future adaptation. To address this hypothesis, we compare the experimental evolution of Caenorhabditis elegans populations under partial selfing, exclusive selfing or predominant outcrossing, while they adapt to osmotically challenging conditions. We find that the ancestral genetic load, as measured by the risk of extinction upon inbreeding by selfing, is maintained as long as outcrossing is the main reproductive mode, but becomes reduced otherwise. Analysis of genome-wide single-nucleotide polymorphisms (SNPs) during experimental evolution and among the inbred lines that survived enforced inbreeding indicates that populations with predominant outcrossing or partial selfing maintained more genetic diversity than expected with neutrality or purifying selection. We discuss the conditions under which this could be explained by the presence of recessive deleterious alleles and/or overdominant loci. Taken together, our observations suggest that populations evolving under partial selfing can gain some of the benefits of eliminating unlinked deleterious recessive alleles and also the benefits of maintaining genetic diversity at partially dominant or overdominant loci that become associated due to variance of inbreeding levels.
Mapping of Novel Leaf Rust and Stem Rust Resistance Genes in the Portuguese Durum Wheat Landrace PI 192051
Authors: Aoun Meriem , Kolmer James A , Rouse Matthew N , Elias Elias M , Breiland Matthew , Bulbula Worku Denbel , Chao Shiaoman , Acevedo Maricelis 
Published: July 2019

Abstract
Leaf rust caused by Puccinia triticina Erikss. (Pt) and stem rust caused by Puccinia graminis f. sp. tritici Erikss. & E. Henn (Pgt) are serious constraints to production of durum wheat (Triticum turgidum L). The objective of this study was to identify leaf rust resistance (Lr) and stem rust resistance (Sr) genes/QTL in Portuguese durum landrace PI 192051. Four Pt-isolates, representing three virulence phenotypes (BBBQJ, BBBSJ & EEEEE) and six Pgt-races TTKSK, JRCQC, TKTTF, QFCFC, TPMKC and TMLKC were used to evaluate 180 recombinant inbred lines (RILs) derived from the cross Rusty (rust susceptible) × PI 192051-1 (rust resistant) at the seedling stage. The RILs were also phenotyped at the adult-plant stage in a stem rust nursery in Ethiopia in 2017. The RILs were genotyped using the Illumina iSelect 9K wheat SNP array. PI 192051-1 carries a previously unidentified major Sr gene designated as QSr.ace-7A on chromosome arm 7AS and Lr gene Lr.ace-4A in the pericentromeric region of chromosome 4A. In addition, three minor Sr QTL QSr.ace-1A, QSr.ace-2B and QSr.ace-4A were mapped in PI 192051-1 on chromosomes 1AL, 2BL, and 4A, respectively Lr.ace-4A could be co-located or tightly linked to QSr.ace-4A. Markers linked to the identified QTL/genes can be used for marker assisted selection. These findings enrich the genetic basis of rust resistance in both durum and common wheat.
Application of Accelerated Activation in Retroperitoneal Video Endoscopic Adrenalectomy for Cushing Syndrome
Authors: Neimark M. I. , Kiselev R. V. 
Published: July 2019

Purpose.To improve the immediate results of surgical treatment of endogenous hypercorticism throughoptimizing the perioperative management of patients using accelerated rehabilitation protocols.Materials and methods.A randomized prospective study of 53 patients with a body mass index 35 kg/m2 was carried out. In the control group (n=27), TIVA based on propofol was used with postoperative analgesia by systemic administration of opioids. In the accelerated rehabilitation protocol group (n=26), we used anesthesia based on low-flow inhalation of desflurane with sympatholytic mixture infusion in intra- and postoperative periods, multimodal postoperative analgesia, and use of accelerated rehabilitation protocol in the perioperative period. The time of patients' achievement of BIS90 index, time of extubation, time of achievement of 10 points by the Aldrete scale and 0 points by the Bidway test, duration of stay in the in-patient hospital, number of postoperative complications were assessed. Effectiveness of analgesia was evaluated by the time of the first analgesia requirement, consumption of narcotic analgesic, VAS and Verbal Descriptor scale.Results.The study revealed that the time of awakening and reaching 10 points by the Aldrete scale in patients of group 2 was significantly shorter than in group 1: 3 (2; 6) and 6.5 (3.5; 9) min respectively (P=0.046). They had fewer postoperative complications, shorter hospitalization time — 58 (39; 71) hours compared to the control group with 74.5 (58.5; 87) hours (P=0.032).Conclusion.Perioperative management of obese patients after retroperitoneal video endoscopic adrenalectomy with the use of accelerated rehabilitation protocols contributed to earlier mobilization, reduction of the number of complications in the early postoperative period, reduction of the duration of stay in the in-patient hospital, which together facilitates improving the immediate results of surgical treatment of endogenous hypercorticism.
Prophylaxis of Reperfusion Complications in Treatment of Acute Myocardial Infarction in Type 2 Diabetes Mellitus Patients
Authors: Kornienko E. A. 
Published: July 2019

Purpose — to identify the possibility of improving the outcome of multimodality treatment of acute myocardial infarction (AMI) in type 2 diabetes mellitus (DM) patients by use of a succinate-containing drug.Materials and methods. The results of examination and treatment of 86 men aged 40 to 70 years with clinical diagnosis of AMI and concomitant type 2 DM were analyzed. The patients were split into two groups depending on use of the succinate-containing drug. Patients of the control group (38 men, 58.3±7.1 years old) received the standard treatment that included percutaneous coronary intervention (PCI). In the main group under study (48 men, 57.6±7.6 years old), the standard therapy complex was complemented with administration of a succinate-containing drug (1.5% succinic acid solution), which was administered first 30–60 minutes prior to PCI intravenously at a dose of 10–12 ml/kg; then, daily once a day, for 5 days at a dose of 5–6 ml/kg. Peculiarities of the AMI clinical course, dynamics of myocardial contractility, values of acid-base balance (ABB), glucose and lactate content, lipid peroxidation (LPO) and antioxidant system (AOS), rheological properties of the blood were evaluated.Results. During AMI type 2 DM patients developed compensated metabolic lactic acidosis and oxidative distress that manifested in considerable activation of LPO and insufficient activity of the enzymatic component of AOS, blood viscosity grew, elasticity of red blood cells fell. Decreased local and global myocardial contractility was noted as well. During PCI in this category of patients, cardiac rhythm disorders developed in 47.4% of cases, 23.7% of which were life threatening, such as multifocal ventricular extra systole and ventricular fibrillation. Conclusion. Administration of a succinate-containing drug during performance of PCI provided correction of the lipid peroxidation processes and rheological properties of the blood in the population studied, facilitated improvement of left ventricle’s systolic and diastolic function, reduced the risk of reperfusion complications.
Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) and polymorphic variants of TREM-1 in the development of multiple organ dysfunction syndrome after coronary artery bypass grafting
Authors: Khutornya M. V. , Ponasenko A. V. , Tsepokina A. V. , Radivilko A. S. , Zhidkova I. I. , Kutikhin A. G. , Krutitsky S. S. , Golovkin A. S. , Grigoriev E. V. 
Published: July 2019

The onset of critical complications (multiple organ dysfunction syndrome, MODS) after coronary artery bypass grafting is the result of severe stress response. The key etiopathological factor of the induction phase of the complex pathological process, which ultimately leads to dysfunction of organs and systems, is the dysfunction of the immune response. The characteristics of reactions of the immune system in a particular individual are genetically determined and realized through innate immunity activation. Aim. To determine the role of TREM-1 gene polymorphism through the changes of sTREM serum levels and their contribution to the development of multiple organ dysfunction syndrome after coronary artery bypass grafting.Materials and Methods. 132 patients with coronary atherosclerosis who had undergone coronary artery bypass grafting were included in the study. Of them, 30 patients had multiple organ dysfunction syndrome in the early postoperative period. sTREM serum levels were measured using enzyme immunoassay. Genotyping of polymorphic loci of the TREM-1 gene was performed with real-time allele-speciﬁc PCR using TaqMan system.Results. Signiﬁcant diﬀerences in sTREM levels among patients with and without MODS were found. sTREM levels depend on the carriage of certain allelic variants in the three polymorphic loci of the TREM-1 gene (rs1817537, rs2234246, rs3804277)Conclusion. The relationships of the levels of the circulating soluble form of TREM-1 and the polymorphic variants of the coding TREM-1 gene with the severity of MODS were determined in coronary artery disease patients after coronary artery bypass grafting.
Screening Criteria for Multiple Organ Dysfunction after Abdominal Surgery (Clinical Research)
Authors: Tachyla S. A. , Marochkov A. V. , Livinskaya V. A. 
Published: July 2019

Objective:to determine the feasibility of using C-reactive protein (CRP) and cholesterol levels as biochemical screening markers for multiple organ dysfunction syndrome (MODS) in patients after abdominal surgery.Materials and methods.A prospective case-control study was performed in 192 patients who receivedtreatment at the Intensive Care Unit (ICU) after abdominal surgery. Patients were classified into two groups: Group 1 (n=95) of patients without MODS and Group 2 (n=97) of patients with MODS. The signs of MODS were identified based on 2001 SCCM/ACCP consensus conference criteria. During the first three post-operative days, total cholesterol and CRP levels were measured, and severity was assessed using prognostic scoring systems (SOFA and Apache III). Logistic regression analysis was used to evaluate five MODS prediction models based on total cholesterol levels, CRP levels, a combination of cholesterol and CRP levels as well as SOFA and Apache III scores.Results.Cholesterol levels in Group 2 were found to be significantly lower than those in Group 1 (3.13 (2.6–3.74) mmol/l vs 4.09 (3.26–5.01) mmol/l;P0.05). Significantly increased CRP levels in Group 2 compared to Group 1 were found (168.7 (90.2–247.2) mg/l vs 85.9 (35.6–172.6) mg/l;P0.05). AUC, sensitivity, and specificity values were determined for the study models and scales based on total cholesterol levels (AUC 0.679; 95% confidence interval (CI) 0.625–0.732), CRP levels (AUC 0.67; 95% CI 0.6–0.74), a combination of cholesterol and CRP levels (AUC 0.819; 95% CI 0.721–0.917), SOFA score (AUC 0.786; 95% CI 0.744–0.829), and Apache III score (AUC 0.631; 95% CI 0.582–0.68). The optimal threshold was 3.4 mmol/l and 96.5 mg/l for cholesterol and CRP levels, respectively.Conclusion.Total cholesterol and CRP monitoring revealed them as screening biomarkers informative for predicting MODS within the first three days after abdominal surgery. Using all these models, the probability of MODS development in a patient can be calculated as a function of the numerical value of the biomarker.
Neuroprotective Eﬀect of Lithium Chloride in Rat Model of Cardiac Arrest
Authors: Ostrova I. V. , Grebenchikov O. A. , Golubeva N. V. 
Published: July 2019

Lithium chloride, which is used for the treatment of bipolar disorders, has a neuroprotective eﬀect in conditions associated with acute and chronic circulatory disorders.The purpose of the study: to investigate the eﬃcacy of lithium chloride for the prevention of post-resuscitation death of hippocampal neurons during the post-resuscitation period.Material and methods. Cardiac arrest for 10 minutes was evoked in mature male rats by intrathoracic clumping of the vascular bundle of the heart, followed by resuscitation. 40 mg/kg or 20 mg/kg of 4,2% lithium chloride (LiCl) was injected intraperitoneally 1 hour before cardiac arrest, on the 1st and 2nd day after resuscitation (n=9). Untreated animals received equivalent doses of saline (n=9). Rats after a sham surgery served as a reference group (n=10). The number of viable neurons in the CA1 and CA3/CA4 ﬁelds of the hippocampus was estimated in slides stained with cresyl violet by day 6 or 7 postresuscitation. In a separate series of experiments, at the same terms, we studied the eﬀect of lithium chloride on the protein content of GSK3β (glycogen synthase kinase) in brain tissue using Western-Blot analysis.Results. Histological assay showed that a 10-minute cardiac arrest resulted in a decrease in the number of viable neurons in the hippocampal CA1 ﬁeld — by 37.5% (P0.001), in the CA3/CA4 ﬁeld — by 12.9% (P0.05) vs. the reference group. Lithium treatment increased the number of viable neurons in resuscitated rats — in the CA1 ﬁeld by 37% (P<0.01), in the CA3/CA4 ﬁeld — by 11.5% (P0.1) vs. the untreated animals. It was found that lithium caused an increase in phosphorylated form of GSK3β: by 180% vs. the reference group (P[1]0.05), and by 150% vs. the untreated animals (P0.05).Conclusion. Lithium treatment leads to a pronounced neuroprotection in the neuronal populations of the hippocampus post-resuscitation. This eﬀect may be due to an increase in the content of the phosphorylated form of GSK3β protein. The results indicate a high potential of lithium for the prevention and treatment of neurodegenerative disorders caused by a temporary arrest of blood circulation.
Az elhízás jelenlegi és prognosztizált betegségterhe a magyarországi romák körében I.
Authors: Kiss Anna , Andó Réka , Fritz Péter , Lakner Zoltán 
Published: July 2019

Abstract: Introduction: The Roma population rapidly gains in importance in the social structure of Hungary. An adverse consequence of the multiple disadvantageous position of this minority is the unhealthy nutrition, which leads to obesity and high prevalence of its co-diseases. Aim: Based on primer anthropometric data collection, we will determine the nutritional status of the Hungarian Roma population, then on the basis of official statistical data, an estimation and prognoses will be prepared on the disease burden of obesity according to genders and age. Method: A long-range forecast of the population size of the Roma minority’s prognosis has been prepared on the basis of official statistics and time-series by Spectrum 5.0 demographic software. On this basis, applying the Dynamic Modeling for Health Impact Assessment software, we have prepared a forecast for the incidence and prevalence of the most important diseases attributable to obesity. Results: In the next decades, the number of the Roma population will be doubled, but there is a high level of uncertainty of different forecasts. The nutritional status of the Hungarian roma population is less favorable, than the indicators, characterizing the Hungarian population as a whole. In the next half a century, the prevalence of co-morbidities of obesity will be increasing from 6 thousand up to 26 thousand in the case of women, while in the case of men from nearly 6 thousand up to 17 thousand. Conclusions: The rapidly increasing number of the Roma population is an increasing challenge for the Hungarian healthcare system, which highlights the importance of evidence-based prevention and intervention programs. Orv Hetil. 2019; 160(28): 1097–1104.
A B9-vitamin élettani és kórélettani jelentősége. Összegzés a folsav táplálékkiegészítőként történő alkalmazásának 30. évfordulójára
Authors: Zsigrai Sára , Kalmár Alexandra , Valcz Gábor , Szigeti Krisztina Andrea , Barták Barbara Kinga , Nagy Zsófia Brigitta , Igaz Péter , Tulassay Zsolt , Molnár Béla 
Published: July 2019

Abstract: Vitamin B9, also known as folate, can be found in natural and synthetic forms, mostly in vegetables or folic acid containing food supplements. By participating in the proper cell development and division, its presence is indispensable for certain basic metabolic processes. The decreased folate level of the body, mainly caused by environmental and hereditary factors as well as aging, can lead to genetic, epigenetic and metabolic changes. It can be related to the development of megaloblastic anemia, various cardiovascular diseases (such as atherosclerosis, stroke) obstetrical complications (such as abruption of the placentae, spontaneous abortion, preterm delivery, neural tube defect), neuropsychiatric diseases (such as Alzheimer’s disease, Parkinson’s disease, depression) and tumors. The vitamin has a preventive effect in all the above-mentioned diseases, however, in the case of tumor existence, its therapeutic use requires great care, as it may promote the progression of certain precancerous lesions. Food fortification with folic acid is currently being carried out in more than 60 countries in order to ensure a minimum vitamin B9 requirement for the population and therefore to prevent the development of the diseases that are connected to folic acid deficiency. Due to its assumable role in carcinogenesis, an initial concern had taken place when fortification was implemented (1998), however, the present statistical data do not confirm such adverse health effects. On the other hand, several beneficial properties can be connected to the vitamin, that can be the reason why more and more countries are considering to join this program. Besides the fact that folic acid is a widely used food supplement, it is also applied in oncological medicine (leucovorin) to increase the effectiveness of certain chemotherapeutical drugs (e.g. methotrexate, 5-fluorouracil). Orv Hetil. 2019; 160(28): 1087–1096.