bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH
Authors: Korać Jelena , Stanković Dalibor M. , Stanić Marina , Bajuk-Bogdanović Danica , Žižić Milan , Pristov Jelena Bogdanović , Grgurić-Šipka Sanja , Popović-Bijelić Ana , Spasojević Ivan 
Published: February 2018

AbstractCoordinate and redox interactions of epinephrine (Epi) with iron at physiological pH are essential for understanding two very different phenomena – the detrimental effects of chronic stress on the cardiovascular system and the cross-linking of catecholamine-rich biopolymers and frameworks. Here we show that Epi and Fe3+form stable high-spin complexes in the 1:1 or 3:1 stoichiometry, depending on the Epi/Fe3+concentration ratio (low or high). Oxygen atoms on the catechol ring represent the sites of coordinate bond formation within physiologically relevant bidentate 1:1 complex. Redox properties of Epi are slightly impacted by Fe3+. On the other hand, Epi and Fe2+form a complex that acts as a strong reducing agent, which leads to the production of hydrogen peroxide via O2reduction, and to a facilitated formation of the Epi–Fe3+complexes. Epi is not oxidized in this process,i.e. Fe2+is not an electron shuttle, but the electron donor. Epi-catalyzed oxidation of Fe2+represents a plausible chemical basis of stress-related damage to heart cells. In addition, our results support the previous findings on the interactions of catecholamine moieties in polymers with iron and provide a novel strategy for improving the efficiency of cross-linking.
Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing
Authors: Karathanasi Georgia , Bojer Martin Saxtorph , Baldry Mara , Johannessen Bárdur Andréson , Wolff Sanne , Greco Ines , Kilstrup Mogens , Hansen Paul Robert , Ingmer Hanne 
Published: February 2018

AbstractStaphylococcus aureus is an important pathogen causing infections in humans and animals. Increasing problems with antimicrobial resistance has prompted the development of alternative treatment strategies, including antivirulence approaches targeting virulence regulation such as the agr quorum sensing system. agr is naturally induced by cyclic auto-inducing peptides (AIPs) binding to the AgrC receptor and cyclic peptide inhibitors have been identified competing with AIP binding to AgrC. Here, we disclose that small, linear peptidomimetics can act as specific and potent inhibitors of the S. aureus agr system via intercepting AIP-AgrC signal interaction at low micromolar concentrations. The corresponding linear peptide did not have this ability. This is the first report of a linear peptide-like molecule that interferes with agr activation by competitive binding to AgrC. Prospectively, these peptidomimetics may be valuable starting scaffolds for the development of new inhibitors of staphylococcal quorum sensing and virulence gene expression.
GourdBase: a genome-centered multi-omics database for the bottle gourd (Lagenaria siceraria), an economically important cucurbit crop
Authors: Wang Ying , Xu Pei , Wu Xiaohua , Wu Xinyi , Wang Baogen , Huang Yunping , Hu Yaowen , Lin Jiandong , Lu Zhongfu , Li Guojing 
Published: February 2018

AbstractGourdBase is an integrative data platform for the bottle gourd to examine its multifarious intuitive morphology and annotated genome. GourdBase consists of six main modules that store and interlink multi-omic data: the genome (with transcriptomic data integrated) module, the phenome module, the markers/QTLs module, the maps (genetic, physical and comparative) module, the cultivars module, and the publications module. These modules provide access to various type of data including the annotated reference genome sequence, gene models, transcriptomic data from various tissues, physical and comparative genome maps, molecular markers in different types, phenotypic data for featuring traits including fruit shape and umami taste, and quantitative trait loci (QTLs) that underlie these traits. GourdBase is intuitive, user-friendly and interlinked and is designed to allow researchers, breeders and trained farmers to browse, search and fetch information on interests and assist in genomics-driven studies and breeding. The knowledge base and web interface can be accessed at http://www.gourdbase.cn/.
Body temperature measurement in mice during acute illness: implantable temperature transponder versus surface infrared thermometry
Authors: Mei Jie , Riedel Nico , Grittner Ulrike , Endres Matthias , Banneke Stefanie , Emmrich Julius Valentin 
Published: February 2018

AbstractBody temperature is a valuable parameter in determining the wellbeing of laboratory animals. However, using body temperature to refine humane endpoints during acute illness generally lacks comprehensiveness and exposes to inter-observer bias. Here we compared two methods to assess body temperature in mice, namely implanted radio frequency identification (RFID) temperature transponders (method 1) to non-contact infrared thermometry (method 2) in 435 mice for up to 7 days during normothermia and lipopolysaccharide (LPS) endotoxin-induced hypothermia. There was excellent agreement between core and surface temperature as determined by method 1 and 2, respectively, whereas the intra- and inter-subject variation was higher for method 2. Nevertheless, using machine learning algorithms to determine temperature-based endpoints both methods had excellent accuracy in predicting death as an outcome event. Therefore, less expensive and cumbersome non-contact infrared thermometry can serve as a reliable alternative for implantable transponder-based systems for hypothermic responses, although requiring standardization between experimenters.
Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death
Authors: Zheng M. , Cao Z. , Vorobyeva Y. , Manrique P. , Song C. , Johnson N. F. 
Published: February 2018

AbstractWe present the continuous-time evolution of an online organism network from birth to death which crosses all organizational and temporal scales, from individual components through to the mesoscopic and entire system scale. These continuous-time data reveal a lifespan driven by punctuated, real-time co-evolution of the structural and functional networks. Aging sees these structural and functional networks gradually diverge in terms of their small-worldness and eventually their connectivity. Dying emerges as an extended process associated with the formation of large but disjoint functional sub-networks together with an increasingly detached core. Our mathematical model quantifies the very different impacts that interventions will have on the overall lifetime, period of initial growth, peak of potency, and duration of old age, depending on when and how they are administered. In addition to their direct relevance to online extremism, our findings may offer insight into aging in other network systems of comparable complexity for which extensive in vivo data is not yet available.
The Mechanisms of Carnosol in Chemoprevention of Ultraviolet B-Light-Induced Non-Melanoma Skin Cancer Formation
Authors: Tong Lingying , Wu Shiyong 
Published: February 2018

AbstractCarnosol is a natural compound extracted from rosemary and sage, which has been demonstrated to have anti-inflammatory, anti-oxidant, and anti-cancer properties. In this report, we evaluated the therapeutic potential and elucidated the potential mechanism of action of carnosol in chemoprevention of ultraviolet B-light (UVB) induced non-melanoma skin cancer formation. Our data indicated that carnosol could partially reduce UVB-induced reactive oxygen species (ROS) elevation and thus reduce DNA damage. It could also reduce UVB-induced formation of cyclobutane pyrimidine dimers (CDP) in keratinocytes possibly through its ability in absorbing UVB radiation. In addition, carnosol could inhibit the UVB-induced activation of NF-κB and also reduce UVB-induced transformation of keratinocytes. Taken together, the results indicate the role of carnosol as a potential chemopreventive agent upon UVB radiation.
A database of chlorophyll a in Australian waters
Authors: Davies Claire H. , Ajani Penelope , Armbrecht Linda , Atkins Natalia , Baird Mark E. , Beard Jason , Bonham Pru , Burford Michele , Clementson Lesley , Coad Peter , Crawford Christine , Dela-Cruz Jocelyn , Doblin Martina A. , Edgar Steven , Eriksen Ruth , Everett Jason D. , Furnas Miles , Harrison Daniel P. , Hassler Christel , Henschke Natasha , Hoenner Xavier , Ingleton Tim , Jameson Ian , Keesing John , Leterme Sophie C. , James McLaughlin M , Miller Margaret , Moffatt David , Moss Andrew , Nayar Sasi , Patten Nicole L. , Patten Renee , Pausina Sarah A. , Proctor Roger , Raes Eric , Robb Malcolm , Rothlisberg Peter , Saeck Emily A. , Scanes Peter , Suthers Iain M. , Swadling Kerrie M. , Talbot Samantha , Thompson Peter , Thomson Paul G. , Uribe-Palomino Julian , van Ruth Paul , Waite Anya M. , Wright Simon , Richardson Anthony J. 
Published: February 2018

AbstractChlorophyll a is the most commonly used indicator of phytoplankton biomass in the marine environment. It is relatively simple and cost effective to measure when compared to phytoplankton abundance and is thus routinely included in many surveys. Here we collate 173, 333 records of chlorophyll a collected since 1965 from Australian waters gathered from researchers on regular coastal monitoring surveys and ocean voyages into a single repository. This dataset includes the chlorophyll a values as measured from samples analysed using spectrophotometry, fluorometry and high performance liquid chromatography (HPLC). The Australian Chlorophyll a database is freely available through the Australian Ocean Data Network portal (https://portal.aodn.org.au/). These data can be used in isolation as an index of phytoplankton biomass or in combination with other data to provide insight into water quality, ecosystem state, and relationships with other trophic levels such as zooplankton or fish.
Bilingualism and Procedural Learning in Typically Developing Children and Children With Language Impairment
Authors: Park Jisook , Miller Carol A. , Rosenbaum David A. , Sanjeevan Teenu , van Hell Janet G. , Weiss Daniel J. , Mainela-Arnold Elina 
Published: February 2018

Purpose
The aim of this study was to investigate whether dual language experience affects procedural learning ability in typically developing children and in children with specific language impairment (SLI).

Method
We examined procedural learning in monolingual and bilingual school-aged children (ages 8–12 years) with and without SLI. The typically developing children (35 monolinguals, 24 bilinguals) and the children with SLI (17 monolinguals, 10 bilinguals) completed a serial reaction time task.

Results
The typically developing monolinguals and bilinguals exhibited equivalent sequential learning effects, but neither group with SLI exhibited learning of sequential patterns on the serial reaction time task.

Conclusion
Procedural learning does not appear to be modified by language experience, supporting the notion that it is a child-intrinsic language learning mechanism that is minimally malleable to experience.
Statistical Methodology for the Analysis of Repeated Duration Data in Behavioral Studies
Authors: Letué Frédérique , Martinez Marie-José , Samson Adeline , Vilain Anne , Vilain Coriandre 
Published: February 2018

PurposeRepeated duration data are frequently used in behavioral studies. Classical linear or log-linear mixed models are often inadequate to analyze such data, because they usually consist of nonnegative and skew-distributed variables. Therefore, we recommend use of a statistical methodology specific to duration data.MethodWe propose a methodology based on Cox mixed models and written under the R language. This semiparametric model is indeed flexible enough to fit duration data. To compare log-linear and Cox mixed models in terms of goodness-of-fit on real data sets, we also provide a procedure based on simulations and quantile–quantile plots.ResultsWe present two examples from a data set of speech and gesture interactions, which illustrate the limitations of linear and log-linear mixed models, as compared to Cox models. The linear models are not validated on our data, whereas Cox models are. Moreover, in the second example, the Cox model exhibits a significant effect that the linear model does not.ConclusionsWe provide methods to select the best-fitting models for repeated duration data and to compare statistical methodologies. In this study, we show that Cox models are best suited to the analysis of our data set.
Electrophilic Metal Homoenolates and Their Application in the Synthesis of Cyclopropylamines
Authors: Rousseaux Sophie , Mills L. 
Published: February 2018

Since their discovery, metal homoenolates have been widely explored as carbon-based nucleophiles for the β-functionalization of carbonyl derivatives. Only recently has it been reported that metal ­homoenolates can react as carbonyl electrophiles. In this context, we have recently discovered that cyclopropylamines can be prepared from cyclopropanols via zinc homoenolate intermediates. This Synpacts ­article will present an overview of the reactivity of homoenolates and our strategy to employ these intermediates for the synthesis of cyclopropylamines. Key mechanistic observations and their influence on reaction optimization will also be discussed.1	Introduction2	Homoenolates as Nucleophiles—Selected Reactivity3	Homoenolates as Electrophilic Reagents4	Conclusion
Mobile Geriatrische Rehabilitation – ein alltagsorientiertes
Behandlungskonzept
Authors: Warnach Martin 
Published: February 2018

Zusammenfassung
Effektive Rehabilitation Eine innovative Form der Rehabilitation, die Mobile Geriatrische Rehabilitation
(MoGeRe) weitet sich mit neuen Standorten aus. Das war lange nicht so, obwohl schon vor gut zehn Jahren die
„Rahmenempfehlungen für die Mobile Geriatrische Rehabilitation“ verabschiedet wurden 1 und der Gesetzgeber vor fünf Jahren die Mobile Rehabilitation als Regelversorgung anerkannt hat
2. Die Krankenkassen hatten erhebliche Vorbehalte, sie sahen neue Kosten
auf sich zukommen. Mittlerweile beginnt sich aber durchzusetzen: Die Mobile Geriatrische Rehabilitation ist
eine am Alltag älterer und pflegebedürftiger Menschen orientierte, effektive Form der Rehabilitation.
Smart Home & Living-Technologien in Bauvorhaben im Sozial- und
Gesundheitswesen
Authors: Cupok Uta , Pfister Verena , Steiner Barbara 
Published: February 2018

Zusammenfassung
Vernetzung IT-gestützte Vernetzung von Pflegenden, Beratern, Architekten und Handwerkern ermöglicht den
fachübergreifenden Einsatz von Smart Home & Living-Technologien in sozialen Einrichtungen, wie z. B. in
Pflegeheimen oder im Betreuten Wohnen. Der Einsatz orientiert sich an individuellen Bedarfen von
unterstützungs- und pflegebedürftigen Personen im stationären und ambulanten Wohnsetting.
Frakturen der Wirbelkörper, der Oberschenkel und des Beckenrings
Authors: Maier Klaus-Jürgen , Knobe Matthias 
Published: February 2018

Zusammenfassung
Fallbeispiele Welche Diagnostik bei Frakturen der Wirbelkörper, der Oberschenkel und des Beckenrings zum
Einsatz kommt, um eine Indikation zu stellen und wie die Patienten am besten therapiert werden können,
schildern unsere Autoren anhand von Praxisbeispielen.
Indikationsqualität. Konzeption und professionsethische Implikationen
Authors: Dörries Andrea 
Published: February 2018

Zusammenfassung
Ziel der Studie In letzter Zeit wird – auch bedingt durch gesetzliche Vorgaben - zunehmend eine gute „Indikationsqualität“ eingefordert. Ziel des Beitrags ist es, zur Klärung der Debatte über die „Indikationsqualität“ beizutragen, indem die Indikationsstellung als ärztliche Tätigkeit genauer in den Blick genommen und nach einem dieser Tätigkeit angemessenem Qualitätsverständnis gefragt wird.
Methodik Es wird zunächst gezeigt, inwiefern die Indikationsstellung integraler Bestandteil des übergeordneten therapeutischen Entscheidungsprozesses ist, in den neben medizinischer Evidenz auch normative Elemente einfließen (Arbeitsschritt 1). In einem zweiten Teil werden 2 unterschiedliche Qualitätsverständnisse kontrastiert (Arbeitsschritt 2): eine extern messbare, standardisierbare Qualität (Q-Qualität) und eine an professionsethischen Werten und Prinzipien orientierte Qualität (T-Qualität).
Ergebnisse Für die Qualitätssicherung der „Indikationsqualität“ wird die Beachtung beider Qualitätsverständnisse begründet dargestellt. Für die Q-Qualität sind quantitative Methoden mit Indikatoren geeignet, für die T-Qualität eignen sich qualitativ-diskursive Verfahren besser.
Schlussfolgerungen Es wird vorgeschlagen, unter „Indikationsqualität“ die Qualität des gesamten therapeutischen Entscheidungsprozesses inkl. der Indikationsstellung zu verstehen. Die Indikationsstellung selbst sollte an professionsspezifische und nicht andere kontextuelle oder „private“ ethische Grundlagen gebunden sein. Die rechtlichen und gesellschaftlichen Rahmenbedingungen sollten positive Anreize für beide Qualitätsverständnisse setzen.
Does an Immigrant Background Affect the Indication, Incidence or Outcome of Emergency Cesarean Section? Results of the Prospective Data Collection of 111 Births
Authors: David Matthias , Scherer Katrin , Henrich Wolfgang , Breckenkamp Jürgen 
Published: February 2018

Abstract
Objectives Does the incidence and/or indication(s) for emergency cesarean section differ if the pregnant woman has an immigrant background (IB)? Does a lack of language proficiency (communication problems) and a low acculturation level result in a longer decision-to-delivery interval (D-D interval)? Are neonates born to women with IB by emergency cesarean section in a poorer condition post delivery?
Patient cohorts and method Standardized interviews were carried out before or immediately after delivery in three Berlin obstetric hospitals. Questions were asked about the sociodemographic background and care aspects as well as about immigration and level of acculturation. Collected data were linked to information obtained from the expectant motherʼs antenatal records and to care data and perinatal data routinely recorded by the hospitals. Data was analyzed using regression models which adjusted for age, parity, and socio-economic status.
Results The total patient population consisted of 7100 women (rate of response: 89.6%); of these women, 111 required emergency cesarean section (50 women without IB, 61 immigrant women). Risk factors such as late first antenatal check-up, gestational diabetes, pregnancy-induced hypertension, fetal macrosomia, smoking, and weight gain were similar in both patient cohorts. The incidence of and indications for emergency cesarean section and the D-D interval were similar for both groups. Limited German language proficiency and low levels of acculturation among immigrant women did not prolong the D-D interval. There were no statistically relevant differences between immigrant and non-immigrant cohorts with regard to adverse neonatal conditions (5-minute Apgar score ≤ 7, umbilical cord arterial pH < 7.00) or with regard to immediate transfer of the neonate to a pediatric clinic following emergency cesarean section.
Conclusion The factor “immigrant background” did not affect the indication or obstetric outcome following emergency cesarean section.
Trauma nach Flucht: NADA-Akupunktur und Qigong
Authors: Friedrichs Elisabeth 
Published: February 2018

SummarySeit dem Sommer 2015 sind Hunderttausende Menschen auf ihrer Flucht aus Bürgerkrieg, Hoffnungslosigkeit, Aussichtslosigkeit nach Europa gekommen. Die meisten sind traumatisiert. Schnelle therapeutische Lösungen sind nicht sichtbar. Hier können niederschwellige Angebote eine erste Anlaufstelle sein. Erfahrungen aus Augsburg und Stuttgart zeigen beispielhaft, dass einfache Konzepte, wie die NADA-Akupunktur oder Qigong-Übungen in der Gruppe, Menschen in schwierigen Lebenssituationen ein wenig auffangen können.
Thyroid-Stimulating Hormone-Stimulated Human Adipocytes Express Thymic Stromal Lymphopoietin
Authors: Ma Loretta , Gagnon AnneMarie , Landry Anne , Le Timothea , Xiao Fengxia , Sun Cathy , Lochnan Heather , Burger Dylan , Sorisky Alexander 
Published: February 2018

AbstractWhen recombinant human (rh) thyroid-stimulating hormone (TSH) is administered to thyroid cancer survivors, an acute extra-thyroidal effect raises pro-inflammatory cytokines and activates platelets. Thymic stromal lymphopoietin (TSLP) is a cytokine recently implicated in platelet activation. Our aim was to measure platelet microparticle levels after rhTSH stimulation in vivo, and to investigate TSLP expression in TSH-stimulated human adipocytes in culture. Blood samples for total and platelet microparticle analysis were obtained from thyroid cancer survivors before (day 1) and after rhTSH administration (day 5). Adipocytes, differentiated from stromal preadipocytes isolated from adipose tissue from surgical patients, were stimulated with TSH. TSLP mRNA expression, protein expression, and protein release into the adipocyte medium were measured. The level of platelet microparticles in thyroid cancer patients rose 5-fold after rhTSH stimulation. TSH upregulated TSLP mRNA expression in adipocytes in culture through a pathway that was inhibited by 66% by H89, a protein kinase A inhibitor. TSLP protein expression rose in response to TSH, and TSH-stimulated TSLP release into the medium was completely blocked by dexamethasone. In conclusion, TSLP is a novel TSH-responsive adipokine. Future studies will be needed to address the potential role of adipocyte-derived TSLP and whether it is linked to TSH-dependent platelet activation.
A semantic challenge to non-realist cognitivism
Authors: Copp David 
Published: February 2018

AbstractRecently, some philosophers have attempted to escape familiar challenges to orthodox nonnaturalist normative realism by abandoning the robust metaphysical commitments of the orthodox view. One such view is the ‘Non-Metaphysical Non-Naturalism’ or ‘Non-Realist Cognitivism’ proposed by Derek Parfit and a few others. The trouble is that, as it stands, Non-Realist Cognitivism seems unable to provide a substantive non-trivial account of the meaning and truth conditions of moral claims. The paper considers various strategies one might use to address the challenge. There is a rich field of views that are cognitivist and non-realist. But the paper is skeptical of the prospects of Non-Realist Cognitivism.