bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomized study of solriamfetol for excessive sleepiness in narcolepsy
Authors: Thorpy Michael J. , Shapiro Colin , Mayer Geert , Corser Bruce C. , Emsellem Helene , Plazzi Giuseppe , Chen Dan , Carter Lawrence P. , Wang Hao , Lu Yuan , Black Jed , Dauvilliers Yves 
Published: January 2019

ObjectiveSolriamfetol (JZP‐110) is a selective dopamine and norepinephrine reuptake inhibitor with wake‐promoting effects. This phase 3 study (NCT02348593) evaluated the safety and efficacy of solriamfetol in narcolepsy.MethodsPatients with narcolepsy with mean sleep latency <25 minutes on the Maintenance of Wakefulness Test (MWT), Epworth Sleepiness Scale (ESS) score ≥10, and usual nightly sleep ≥6 hours were randomized to solriamfetol 75, 150, or 300 mg, or placebo for 12 weeks. Coprimary endpoints were change from baseline to week 12 in MWT and ESS. Improvement on the Patient Global Impression of Change (PGI‐C) was the key secondary endpoint.ResultsSafety and modified intention‐to‐treat populations included 236 and 231 patients, respectively. Solriamfetol 300 and 150 mg were positive on both coprimary endpoints. Least squares mean (standard error [SE]) changes from baseline were 12.3 (SE = 1.4) and 9.8 (SE = 1.3) minutes for solriamfetol 300 and 150 mg on the MWT, respectively, versus 2.1 (SE = 1.3) minutes for placebo, and −6.4 (SE = 0.7) for 300 mg and −5.4 (SE = 0.7) for 150 mg on the ESS versus −1.6 (SE = 0.7) for placebo (all p < 0.0001). At week 12, higher percentages of patients treated with solriamfetol 150 mg (78.2%) and 300 mg (84.7%) reported PGI‐C improvement relative to placebo (39.7%; both p < 0.0001). Adverse events ≥5% across all solriamfetol doses included headache (21.5%), nausea (10.7%), decreased appetite (10.7%), nasopharyngitis (9.0%), dry mouth (7.3%), and anxiety (5.1%).InterpretationSolriamfetol has the potential to be an important therapeutic option for the treatment of impaired wakefulness and excessive sleepiness in patients with narcolepsy. ANN NEUROL 2019;85:359–370.
Catalytic and biological valorization of a supramolecular mononuclear copper complex based 4‐aminopyridine
Authors: Hfidhi Nabil , bkhairia Intidhar , Atoui Dhieb , Boonmak Jaursup , Nasri Moncef , Ben Salem Ridha , Youngme Sujittra , Naïli Houcine 
Published: January 2019

Hydrothermal reaction of copper bromide with 4‐aminopyridine in DMF solution yields a new mononuclear copper complex [Cu(C5H6N2)4]2Br.2(C3H7NO) abbreviated Cu‐4AP‐Br. The product was characterized, structurally, by single‐crystal X‐ray diffraction analysis and, thermally, by DSC‐ATG measurement. The inorganic–organic hybrid compound Cu‐4AP‐Br crystallizes in the centrosymmetric space group Pbcn, exhibiting a supramolecular network. Simultaneous DSC‐ATG analysis shows that this compound remains stable up to 100 °C and then performs a successive decompositions accompanied with endothermic peaks. The complex Cu‐4AP‐Br was applied as a catalyst in the Heck coupling reaction under ultrasonic irradiation in various reaction conditions. The yields, obtained for a short period of time, allow us to consider this complex, generating selectivity on the external position of styrene with a preference of the trans form over cis, as an excellent catalyst for this type of reaction. Interestingly, Cu‐4AP‐Br displayed important antibacterial (Gram‐positive and Gram‐negative) and antioxidant activities (β‐carotene bleaching inhibition, scavenging effect on DPPH free radical, and reducing power).
OR Time and Sacral Pressure Injuries in Critically Ill Surgical Patients
Authors: Grap Mary Jo , Schubert Christine M. , Munro Cindy L. , Wetzel Paul A. , Burk Ruth S. , Lucas Valentina , Pepperl Anathea 
Published: January 2019

AbstractCritically ill patients are at risk for developing pressure injuries during operative and other invasive procedures. The purpose of this secondary analysis was to explore the relationship of OR time to sacral pressure injuries in critically ill patients using high frequency ultrasound as a method of assessment. The 41 participants examined in this study had both time in the OR and up to eight days of pressure injury data. The multivariable model containing OR bed time, body mass index, and Braden Scale score produced the best prediction of pressure injury (area under the curve = 0.859). A higher body mass index (P = .09), shorter OR bed time (P = .01), and lower Braden Scale score (P = .05) were associated with a greater chance of pressure injury. These results suggest that use of high frequency ultrasound may identify tissue changes before observable skin changes, leading to earlier pressure injury prevention strategies.
Novel approach to promote the hydrophobic association: Introduction of short alkyl chains into hydrophobically associating polyelectrolytes
Authors: Han Yuhao , Tan Jiawen , Wang Dongping , Xu Kun , An Huiyong 
Published: January 2019

ABSTRACTA novel approach to promote hydrophobic association by incorporating short alkyl chains onto polyelectrolytes (HAPEs) was presented. A series of HAPEs was synthesized by free radical copolymerization in aqueous media with acrylamide (AM), 11‐acrylamidoundecanoic acid (C11AM), and 6‐acrylamidohexanoic acid (C6AM). The structures and compositions of the polymers were confirmed by 1H‐NMR, and the molecular weights were determined by GPC. Results of rheological experiments revealed that viscosities increased greatly in samples containing C11AM and C6AM compared with the sample without C6AM. The sample without C6AM was also characterized by critical association concentrations and critical angular frequencies. Solubilization and bridging interaction were considered as the possible reasons. Pyrene fluorescence probe data and 1H‐NMR spin–spin relaxation times further illustrated the reinforcement of hydrophobic associations by short alkyl side chains. All the results showed that the optimum content of C6AM was 1 mol % in the prepared HAPEs. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47581.
Enzyme production by solid‐state fermentation on soybean meal: A comparative study of conventional and ultrasound‐assisted extraction methods
Authors: Salim Abdalla Ali , Grbavčić Sanja , Šekuljica Nataša , Vukašinović‐Sekulić Maja , Jovanović Jelena , Jakovetić Tanasković Sonja , Luković Nevena , Knežević‐Jugović Zorica 
Published: January 2019

AbstractProtease, cellulase, and α‐amylase producing Bacillus subtilis strain was cultivated by solid‐state fermentation technique using soybean meal as a substrate. The aim of the present study was to establish a highly efficient enzymes’ extraction method as a first stage in downstream processing. The conventional extraction procedure was optimized by determining pH, stirring rate, solid/liquid ratio, and time of extraction on enzymes’ recoveries from fermented soybean meal. Yields of leached enzymes were compared to the amounts of enzymes that are achieved with ultrasound‐assisted extraction (UAE). UAE was established to be superior method for obtaining higher yields of proteases (up to 330 IU) and α‐amylases (825 IU), under significantly shorter extraction time and gaining more concentrated product. However, the obtained model predicts that conventional process led to a product with a higher cellulolytic activity (≥7.5 IU).
Electrochemiluminescent functional nucleic acids‐based sensors for food analysis
Authors: Xu Huifeng , Zhu Xi , Wang Jian , Lin Zhenyu , Chen Guonan 
Published: January 2019

AbstractFoodborne contaminants widely exist in foods, which can lead to various foodborne diseases and food safety issues. The development of quick, sensitive and universal analytical approaches for foodborne contaminants is imperative. Electrochemiluminescent functional nucleic acids (ECL FNAs)‐based sensors are a series of sensing devices using FNAs as the recognition elements and ECL as the transducer. Contributing to the specific recognition ability of FNA and the high sensitivity of ECL, ECL FNA‐based sensors are considered to be of great application potential for foodborne contaminants monitoring. This review mainly presents the applications of ECL FNA‐based sensors for foodborne contaminants (including microorganisms, mycotoxins, allergens, antibiotics, heavy metal ions, pesticides and some illegal additives). In general, the application of ECL FNA‐based sensors in the field of food analysis is just in its infancy. Although there are several limitations and challenges, it is envisaged that ECL FNA‐based sensors will have broad prospects for food analysis in the future.
Human T lymphotropic virus type 1 and risk of cardiovascular disease: High‐density lipoprotein dysfunction versus serum HDL‐C concentrations
Authors: Samadi Sara , Abolbashari Samaneh , Meshkat Zahra , Mohammadpour Amir Hooshang , Kelesidis Theodoros , Gholoobi Aida , Mehramiz Mehrane , Tabadkani Mahla , Sadabadi Fatemeh , Dalirfardouei Razieh , Ferns Gordon A , Ghayour‐Mobarhan Majid , Avan Amir 
Published: January 2019

AbstractHigh‐density lipoprotein (HDL) is thought to be protective against cardiovascular disease (CVD), and HDL dysfunction is considered to be a risk factor for CVD. It is unclear whether there is an association between Human T lymphotropic virus type 1 (HTLV1) infection and CVD risk. We have assessed HDL lipid peroxidation (HDLox) as a marker of HDL dysfunction and CVD risk in a subgroup of the MASHAD cohort study. One hundred and sixty two individuals including 50 subjects positive for HTLV1 infection and 112 individuals negative for HTLV1 infection were recruited. Anthropometric and biochemical parameters including serum hs‐CRP, fasted lipid profile (HDL‐C, LDL, triglycerides, and cholesterol), and fasting blood glucose were determined. Serum HDLox was also measured in the study participants. Multivariate analyses were used to evaluate the association between serum HDLox and HTLV1 infection. None of the traditional CVD risk factors were associated with HTLV1 infection, including serum HDL‐C. However, serum HDLox was independently associated with the presence of HTLV1 infection. Logistic regression analysis showed that subjects who were positive for HTLV1 infection were also significantly more likely than uninfected individuals to have higher HDLox (odds ratio 9.35, 95%CI: 3.5–24.7; P < 0.001). HDLox was increased approximately 20% (P < 0.001) in infected subjects compared to the uninfected group. Serum HDLox is a marker of CVD risk factor and increased in individuals affected by HTLV1 infection compared to healthy subjects. © 2019 BioFactors, 45(3):374–380, 2019
The preoperative neutrophil‐to‐lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving radical prostatectomy
Authors: Cao Zhi , Ji Jin , Zhang Chao , Wang Fubo , Xu Huan , Yu Yongwei , Sun Yinghao 
Published: January 2019

AbstractThe neutrophil‐to‐lymphocyte ratio (NLR) has been reported to be a prognostic marker in prostate cancer. In this study, we assessed the association between preoperative NLR and the clinicopathological characteristics, biomolecular features and prognosis of patients with localized prostate cancer treated with radical prostatectomy. A total of 994 subjects were retrospectively enrolled, and the histological specimens of 210 patients were retrieved for constructing a tissue microarray. Immunohistochemistry was then performed to assess the expression of AR, ERG, PTEN, p‐AKT, Bcl‐2, Beclin‐1, Ki‐67, CD3, CD4, CD8, IFN‐γ and TNF‐α. No significant differences in the NLR distributions among clinicopathological variables were observed (P > 0.05) when the original NLR data were utilized. When we dichotomized the NLR value into the high‐NLR group (NLR ≥ 2) and low‐NLR group (NLR < 2), we found that the patients in the high‐NLR group had more prostate capsule invasion (P = 0.047). Additionally, no significant correlation was found between the NLR and infiltrating CD3+ cells, the CD4/CD8 ratio, AR, ERG, PTEN, p‐AKT, Bcl‐2, Beclin‐1, Ki‐67, IFN‐γ or TNF‐α (P > 0.05). When we analyzed the data of patients without postoperative adjuvant hormone therapy or radiotherapy, univariate and multivariate survival analysis indicated that a high NLR was a predictor of better BCR‐free survival (P < 0.05). When analyzing the entire cohort, univariate survival analysis showed that the high‐NLR group had significantly poorer overall survival (P < 0.05). In conclusion, NLR cannot reflect prostate cancer characteristics or the local immune microenvironment, but a high NLR can serve as an independent predictor of better BCR.
Long‐term survival outcome with tyrosine kinase inhibitors and surgical intervention in patients with metastatic or recurrent gastrointestinal stromal tumors: A 14‐year, single‐center experience
Authors: Kim Jwa Hoon , Ryu Min‐Hee , Yoo Changhoon , Chae Heejung , Na Hana , Beck Moyoul , Kim Beom Su , Yoo Moon‐Won , Yook Jeong Hwan , Kim Byung Sik , Kim Ki‐Hun , Kim Chan Wook , Kang Yoon‐Koo 
Published: January 2019

AbstractThe long‐term effects of tyrosine kinase inhibitors (TKIs), including imatinib, and surgical intervention on advanced gastrointestinal stromal tumor (GIST) were evaluated. All 379 patients had metastatic or recurrent GIST and started 400 mg/d imatinib at the Asan Medical Center in periods 1 and 2 [2001‐2007 (33.2%) and 2008‐2014 (66.8%), respectively]. Men constituted 60.4%; median patient age and tumor size at the initiation of imatinib were 58.6 (14.6‐85.5) years and 51 (0‐324) mm, respectively, without differences between periods except for older age and less preimatinib surgery in period 2. Response and disease control rates with imatinib in measurable GIST were 63.1% and 94.3%, respectively, without differences between periods. More patients in period 2 underwent surgical resection for TKI‐responsive diseases within the first 2 years (24.9%, P = 0.006). With a median follow‐up of 6.1 years (2.5‐16.0) in survivors, median progression‐free survival (PFS) was 5.4 years [95% confidence interval (CI), 4.0‐6.9]. Subsequent sunitinib (P = 0.066) and regorafenib (P = 0.003) were more commonly administered in period 2. Median overall survival (OS) was 8.8 years (95% CI, 7.8‐9.7). PFS with imatinib (P = 0.002) and OS (P = 0.019) were significantly longer in period 2. Young age, smaller tumor size at the initiation of imatinib, KIT exon 11 mutation, surgical intervention, and period 2 were favorable factors for PFS and OS. Patients with advanced GIST showed better prognosis with the optimal use of imatinib, along with active surgical intervention and more common use of subsequent TKIs in period 2.
Orthogonally Stimulated Assembly/Disassembly of Depsipeptides by Rational Chemical Design
Authors: Pieszka Michaela , Sobota Adriana Maria , Gačanin Jasmina , Weil Tanja , Ng David Y. W. 
Published: January 2019

AbstractControlling the assembly and disassembly of cross‐β‐sheet‐forming peptides is one of the predominant challenges for this class of supramolecular material. As they constitute a continuously propagating material, every atomic change can be exploited to bring about distinct responses at the architectural level. We report herein that, by using rational chemical design, serine and methionine can both be used as orthogonal chemical triggers to signal assembly/disassembly through their corresponding stimuli. Serine is used to construct an ester‐bond oligopeptide that can undergo O,N‐acyl rearrangement, whereas methionine is sensitive to oxidation by H2O2. Using the example peptide sequence, KIKISQINM, we demonstrate that assembly and disassembly can be independently controlled on demand.
On the Limited Role of Electronic Support Effects in Selective Alkyne Hydrogenation: A Kinetic Study of Au/MOx Catalysts Prepared from Oleylamine‐Capped Colloidal Nanoparticles
Authors: Bruno James E. , Sravan Kumar K. B. , Dwarica Nicolas S. , Hüther Alexander , Chen Zhifeng , Guzman Clemente S. , Hand Emily R. , Moore William C. , Rioux Robert M. , Grabow Lars C. , Chandler Bert D. 
Published: January 2019

AbstractWe report a quantitative kinetic evaluation and study of support effects for partial alkyne hydrogenation using oleylamine‐capped Au colloids as catalyst precursors. The amine capping agents can be removed under reducing conditions, generating supported Au nanoparticles of ∼2.5 nm in diameter. The catalysts showed high alkene selectivity (>90 %) at all conversions during alkyne partial hydrogenation. Catalytic activity, observed rate constants, and apparent activation energies (25–40 kJ/mol) were similar for all Au catalysts, indicating support effects are relatively small. Alkyne adsorption, probed with FTIR and DFT, showed adsorption on the support was associated with hydrogen‐bonding interactions. DFT calculations indicate strong alkyne adsorption on Au sites, with the strongest adsorption sites at the metal‐support interface (MSI). The catalysts had similar hydrogen reaction orders (0.7–0.9), and 1‐octyne reaction orders (∼−0.2), suggesting a common mechanism. The reaction kinetics are most consistent with a mechanism involving the non‐competitive activated adsorption of H2 on an alkyne‐covered Au surface.
Intercalating MnO2 Nanosheets With Transition Metal Cations to Enhance Oxygen Evolution
Authors: Yang Yue , Su Xingsong , Zhang Lei , Kerns Peter , Achola Laura , Hayes Veronica , Quardokus Rebecca , Suib Steven L. , He Jie 
Published: January 2019

AbstractThe catalytic activity of MnO2 nanosheets towards oxygen evolution depends highly on their interlayer environment. We present a systematic investigation on fine‐tuning of the interlayer environment of MnO2 nanosheets by intercalation through a facile cation exchange with inexpensive first‐row transition metal cations, including Ni2+, Co2+, Cu2+, Zn2+, and Fe3+ ions. Among them, the Ni‐intercalated MnO2 nanosheets show remarkably enhanced OER activity and long‐term stability, compared to pristine MnO2 nanosheets. The overpotential of 330 mV at a current density of 10 mA cm−2 is observed for the Ni‐intercalated MnO2 nanosheets. The ehancement mechanism of OER is studied by comparing physiochemical properties, such as the oxidation state of Mn, the interlayer distance, the increase in the disorder/twisting of MnO6 octahedra, and the interlayer cooperative binding of water molecules. The Ni intercalation, different from other metal cations, strengthens the Mn−O bond perpendicularly to the layer chains to facilitate the interlayer catalysis possibly between two Mn sites, and thus promotes the efficiency of oxygen evolution.
Carbon with Surface‐Enriched Nitrogen and Sulfur Supported Au Catalysts for Acetylene Hydrochlorination
Authors: Wang Bolin , Zhao Jia , Yue Yuxue , Sheng Gangfeng , Lai Huixia , Rui Jiayao , He Haihua , Hu Zhongting , Feng Feng , Zhang Qunfeng , Guo Lingling , Li Xiaonian 
Published: January 2019

AbstractThe front cover artwork for Issue 03/2019 is provided by researchers from Industrial Catalysis Institute, Laboratory Breeding Base of Green Chemistry‐Synthesis Technology, Zhejiang University of Technology (P. R. China). The image shows carbon with surface‐enriched nitrogen and sulfur supported Au catalysts for acetylene hydrochlorination. The sulfur species on the carbon surface was considered to be able to selective formation of pyrrolic nitrogen against pyridinic nitrogen, which significantly influence the catalytic performance of Au‐based catalysts.. See the Full Paper itself at https://doi.org/10.1002/cctc.201801555.
Activated Carbon‐Supported Mo‐Co‐K Sulfide Catalysts for Synthesizing Higher Alcohols from CO2
Authors: Liu Su , Zhou Haibo , Zhang Lin , Ma Zhen , Wang Yangdong 
Published: January 2019

AbstractActivated carbon‐supported Mo‐Co‐K sulfide catalysts, prepared by stepwise impregnation, were used in the synthesis of higher alcohols via CO2 hydrogenation. The catalysts with varying Mo contents and defined K/Mo and Co/Mo molar ratios exhibited relatively high CO2 conversions and high selectivity to total alcohols and C2+ alcohols. Moreover, the influence of calcination conditions on the sulfidation states and catalytic performance was studied. The surface sulfur runoff of the supported catalysts can be effectively suppressed by online calcination. As a result, the selectivity to total alcohols and C2+ alcohols can be improved.
What the Combustion Engineer Gains from CFD Modeling: Gas Furnace
Authors: Hájek Jiří , Vondál Jiří , Juřena Tomáš , Sláma Jaroslav 
Published: January 2019

AbstractCombustion engineers require correct predictions of trends, especially in cases when computational fluid dynamics is applied for troubleshooting, scale‐up, or decision support in the design phase. Validation of models by parametric studies and in a large‐scale furnace is rare and much needed. This is the primary objective of this work. Similarly, combustion engineers require the prediction of heat loads in specific parts of a boiler or furnace. The second objective of this work is to provide exactly such type of validation for a megawatt‐scale burner. Both cases use natural gas fuel. The models applied to perform the predictions are typical of practicing combustion engineers, providing fast turnaround times. The results provide a perspective on the performance of models serving as workhorses in engineering companies.
Effects of Graphene Quality on Lithium Storage Performances of Fe3O4/Thermally Reduced Graphene Oxide Hybrid Anodes
Authors: Chang Wei , Qu Jin , Hao Shu‐Meng , Zhang Yu‐Jiao , Jiang Zhi‐Guo , Yu Zhong‐Zhen 
Published: January 2019

AbstractTill now, there are no systematic reports on the effect of the quality of thermally reduced graphene oxide (TRG) on lithium storage properties, as the reported methods to fabricate graphene‐based electrodes are usually not effective enough to reduce graphene oxides to graphene. Herein, graphite oxide is thermally exfoliated and annealed with a high‐temperature graphitization oven at different temperatures (800–2000 °C). A series of Fe3O4/TRG hybrids are synthesized as anode materials for lithium‐ion batteries with TRGs acting as substrates of in‐situ formed Fe3O4 nanoparticles. Both, the electroconductivity of the TRGs and their interfacial interaction with Fe3O4 influence the lithium storage performances of the hybrids. However, the electroconductivity of the TRGs and the formation of interfacial bonds are conflicting. Because the oxygen‐containing groups and defects of TRG are greatly removed leading to enhanced electrical conductivity with the increase of thermal annealing temperature. Hence, the resulting Fe3O4/TRG hybrids show first decreased then increased electrochemical performances with increasing annealed temperatures. In a word, the effect of interfacial interaction is dominant at a relatively low annealing temperature, while the effect of conductivity is dominant at a relatively high annealing temperature. The optimized hybrids exhibit excellent cycling and rate performances. This work should provide useful information for the rational design and construction of high‐performance electrodes for energy storage applications.
Palladium(0)‐Catalyzed Intermolecular Asymmetric Cascade Dearomatization Reaction of Indoles with Propargyl Carbonate
Authors: Ding Lu , Gao Run‐Duo , You Shu‐Li 
Published: January 2019

AbstractAn intermolecular asymmetric cascade dearomatization reaction of indole derivatives with propargyl carbonate was developed. The challenges associated with both the chemoselectivity between the carbon and nitrogen nucleophile and the enantioselective control during the formation of an all‐carbon quaternary stereogenic center were well addressed by a Pd catalytic system derived from the Feringa ligand. A series of enantioenriched multiply substituted fused indolenines were provided in good yields (71–86 %) with excellent enantioselectivity (91–96 % ee) and chemoselectivity (3/4>19:1 in most cases).