bluuebunny/crossref_metadata_2025_split huggingface dataset:
Persistence of Diabetes and Hypertension After Multimodal Treatment of Acromegaly
Authors: González Baldomero , Vargas Guadalupe , de los Monteros Ana Laura Espinosa , Mendoza Victoria , Mercado Moisés 
Published: March 2018

Abstract

Context
Diabetes and hypertension are frequent comorbidities of acromegaly.

Objective
To analyze the course of diabetes and hypertension at diagnosis and after multimodal therapy in a large cohort of patients with acromegaly.

Design and Setting
Retrospective study at a tertiary care center.

Patients and Methods
A total of 522 patients with acromegaly treated according to a preestablished protocol.

Main Outcome Measures
Prevalence of diabetes and hypertension and its relationship with biochemical indices of acromegalic control.

Results
The cohort was stratified according to disease activity upon last visit to clinic: (1) surgical remission (n = 122), (2) pharmacologically controlled (n = 92), (3) active disease (n = 148), (4) insulinlike growth factor (IGF)-1 discordance (n = 64), and (5) growth hormone (GH) discordance (n = 96). The prevalence of diabetes and hypertension at diagnosis was 30% and 37%, respectively, and did not change upon the last visit (30.6% and 38%). Both comorbidities were more prevalent at diagnosis and on the last visit than in the general population. Diabetes was less prevalent on the last visit in patients who achieved surgical remission than in those who persisted with active disease (25% vs 40%, P = 0.01). Upon multivariate analysis, diabetes was associated with an IGF-1 at diagnosis &gt;2× upper limit of normal, with the persistence of active acromegaly, the presence of hypertension upon the last visit, with the presence of a macroadenoma, and with female sex.

Conclusion
Our findings underscore the importance of an integral approach when managing these patients, focusing not only on the control of GH and IGF-1 levels but also on the timely diagnosis and the specific treatment of each comorbidity.
Neurocognition, sleep, and PET findings in type 2 vs type 1 narcolepsy
Authors: Huang Yu-Shu , Hsiao Ing-Tsung , Liu Feng-Yuan , Hwang Fang-Ming , Lin Kuang-Lin , Huang Wen-Cheng , Guilleminault Christian 
Published: March 2018

ObjectiveTo analyze differences in functional brain images collected in patients with type 2 and type 1 narcolepsy compared to normal controls and the relationship among brain images, objective neuropsychologic tests, and sleep findings.MethodsData collection included comprehensive clinical investigation, study of sleep/wake with actigraphy, polysomnography, Multiple Sleep Latency Test, human leukocyte antigen typing, 18F-fluorodeoxyglucose PET, and cognitive tests obtained from 29 patients with type 2 narcolepsy, 104 patients with type 1 narcolepsy, and 26 sex- and age-matched normal control individuals. Conners’ Continuous Performance Test (CPT II) and Wisconsin Card-Sorting Task were performed simultaneously with the FDG-PET examination. After analyses of variance, data between patients with type 1 and type 2 narcolepsy were compared by post hoc analysis, and correlation between functional brain imaging findings and results of neurocognitive tests was obtained.ResultsAll patients with narcolepsy presented with at least 2 sleep-onset REM periods (SOREMP) and subjective sleepiness. Patients with type 2 narcolepsy compared to patients with type 1 narcolepsy had significantly less SOREMP, longer mean sleep latencies, and lower body mass indexes, apnea-hypopnea indexes, and frequency of human leukocyte antigen DQ-Beta1*0602. In patients with type 2 narcolepsy, FDG-PET studies showed significantly less hypermetabolism in the fusiform gyrus, striatum, hippocampus, thalamus, basal ganglia, and cerebellum than in patients with type 1 narcolepsy, and significantly less hypometabolism in the regions of frontal lobe, posterior cingulum, angular gyrus, and part of the parietal lobe; these changes were associated with fewer errors on the CPT.ConclusionYoung patients with type 2 narcolepsy have fewer clinical impairments and less distinct brain functional abnormalities than patients with type 1 narcolepsy, who are significantly more affected.
Adaptive interaction as a method of non-verbal communication in individuals with dementia
Authors: Currie Linda 
Published: March 2018

In the final stages of dementia, individuals may lose the ability to use verbal language. Linda Currie explains how staff in general practice can use a method called adaptive interaction to help communicate with people living with dementiaSignificant numbers of people in the UK are living with dementia. In the final stages of dementia, individuals may experience a loss of verbal language ability. All staff in general practice are in a key position to engage with individuals using non-verbal communication methods. Adaptive interaction is one such method, which is simple to initiate, and in doing so offers a lifeline to help prevent social isolation.
The girl, nature, goddess, or how Marilyn Monroe became ‘the queen of glamour’?
Authors: Łuksza Agata 
Published: March 2018

Abstract
‘Did you ever see anything like her?’, Cleveland Amory asked Hedda Hopper while they were both watching the making of the famous ‘bathtub scene’ in The Seven Year Itch (Wilder, 1955). How can one explain the phenomenon of Marilyn Monroe – the ‘queen of glamour’, as her contemporaries called her? This research examines the case of Marilyn Monroe with reference to the model of glamorous femininity which has emerged in modern consumer societies. Monroe is understood as a ‘representative character’, not a real person, and the study aims at reconstructing and deconstructing her public image, not at establishing the ‘truth’ about her personal life. The most influential components of Monroe’s persona are indicated and analysed based on press material from her lifetime and her repertoire, i.e. the pin-up context, the association with nature and the ‘goddess’ aspect. It is maintained that these components accounted for Monroe’s lasting status as an icon of glamour but also best corresponded to the changes in morality and sexuality that American society experienced in the 1950s.
Lyric images, everlasting instants: The photographic works of Tacita Dean and Roni Horn
Authors: Thornton Becca 
Published: March 2018

Abstract
Of the most recent turn to literary practices in contemporary art, this article studies one facet: that which relates to the lyric tradition. It hopes to make a case for ‘lyric images’, drawing on the works by artists Tacita Dean, Day for Night (2009), and Roni Horn, Still Water [...] (1999). Read around poems by Emily Dickinson, John Fuller and Margaret Atwood, how these artworks utilize photography’s natural capacity to mirror both the recursive syntactic structure and the blending of instantaneity with immortality common to the lyric poem is explored. Particularly, the article considers notions of cyclical seriality – as composed of singular moments, yet tending towards the infinite – both formally and referentially. Whether these qualities provoke an imaginative and/or emotive looking that contrasts with our response to previous assumptions of the written form in conceptual art practices (e.g. Art and Language) is also reflected upon, in order to contemplate why this particular hybridising may be current in photographic practice.
Aberrant flight paths: The uncertain bearings of Malaysian Airlines f﻿light MH370
Authors: Simmons Matthew 
Published: March 2018

Abstract
This article examines the disappearance of Malaysian Airlines MH370 through the lens of its varied non-human witnesses. By employing Harun Farocki’s notion of operative images in conjunction with the process philosophy of Alfred North Whitehead it plots a radically dispersed and autonomous image-making apparatus that captured the event of the aircraft’s disappearance and accelerated the expansion of the event itself. Crucially, this article proposes that these images cannot be understood in terms of vision but must be read instead as a series of tactile or synaesthetic practices between materials. Through examining contemporary image-making technologies employed in the search for the aircraft, it charts an ontological tactility within image making, one that – it is argued – has been present since the birth of the medium itself.
Reinventing the body on the photographic stage: Theatricality, identity, and figural writing in the work of Helena Almeida
Authors: Duarte Miguel Mesquita , Marques Bruno 
Published: March 2018

Abstract
The fictional regime of the photographic image allows Helena Almeida to stage a theatrical metamorphosis of her own body through displacements, expansions and dissimulations, placing photography at the heart of a pictorial transgression that undermines the disciplinary boundaries of visual media: the artist becomes ink, inhabits the empty canvas space, multiplies herself in mirror games that produce the unfolding of a body in deep crisis, thrown beyond its physical limits and identity. Moreover, in multimedia works such as Feel me, Hear me and See me (1979–1980), as well as in some images of the series entitled The House (1982–1983), Almeida seems to move towards a radical linguistic and pictorial derangement, likely to break the traditional communicative and representative mechanisms. We seek to demonstrate, on the basis of these different aspects relating to photography’s effects of hybridization, and making use of the post-structuralist thought of Jacques Derrida and Gilles Deleuze, that the artist moves towards the designation of a structural space that combines photography, writing and the reinvention of the body. Almeida’s work confronts us with a complex reconfiguration of ways of seeing, feeling and thinking the photographic act, as well as its discursive features.
Crystal structure of bis(μ-N-i-propyl-N-n-propyldithiocarbamato-κ3
S,S′:S)bis(N-i-propyl-N-n-propyldithiocarbamato-κ2
S,S′)dicadmium(II), C28H56Cd2N4S8
Authors: Tan Yee Seng , Tiekink Edward R.T. 
Published: March 2018

Abstract
C28H56Cd2N4S8, monoclinic, P21/n (no. 14), a = 9.9003(3) Å, b = 11.7373(3) Å, c = 17.4539(5) Å, β = 102.999(3)°, V = 1976.22(10) Å3, Z = 2, R
gt(F) = 0.0243, wR
ref(F
2) = 0.0582, T = 100 K.
Synthesis and crystal structure of bis(μ2-acetato-κ2
O:O′)-di(ethanol)-bis{μ2-5-(N,N′-diethylamine)-5′-methoxyl-2,2′-[ethylenediyldioxybis(nitrilomethylidyne)]diphenolato-κ6
O:O,N,N,O′:O′}trinickel(II) – ethanol – acetonitrile (1/2/2), C58H86Ni3N8O18
Authors: Zong-Li Ren , Xiao-Xin An , Ling-Zhi Liu , Peng-Fei Lan , Wen-Kui Dong 
Published: March 2018

Abstract
C58H86Ni3N8O18, triclinic, P1̅ (no. 2), a = 11.4561(8) Å, b = 13.1859(8) Å, c = 13.5063(11) Å, α = 109.620(7)°, β = 101.234(7)°, γ = 114.469(6)°, V = 1611.1(2) Å3, Z = 1, R
gt(F) = 0.0518, wR
ref(F
2) = 0.1315, T = 173.69(10) K.
Crystal structure of N-(3-chlorophenyl)ethoxycarbothioamide, C9H10ClNOS
Authors: Tan Yee Seng , Yeo Chien Ing , Tiekink Edward R.T. 
Published: March 2018

Abstract
C9H10ClNOS, monoclinic, C2/c (no. 15), a = 18.8783(6) Å, b = 4.5518(2) Å, c = 23.6739(8) Å, β = 91.501(4)°, V = 2033.61(13) Å3, Z = 8, R
gt(F) = 0.033, wR
ref(F
2) = 0.082, T = 100(2) K.
Effects of Larval Density on Gene Regulation in Caenorhabditis elegans During Routine L1 Synchronization
Authors: Chan Io Long , Rando Oliver J , Conine Colin C 
Published: March 2018

Abstract
Bleaching gravid C. elegans followed by a short period of starvation of the L1 larvae is a routine method performed by worm researchers for generating synchronous populations for experiments. During the process of investigating dietary effects on gene regulation in L1 stage worms by single-worm RNA-Seq, we found that the density of resuspended L1 larvae affects expression of many mRNAs. Specifically, a number of genes related to metabolism and signaling are highly expressed in worms arrested at low density, but are repressed at higher arrest densities. We generated a GFP reporter strain based on one of the most density-dependent genes in our dataset – lips-15 – and confirmed that this reporter was expressed specifically in worms arrested at relatively low density. Finally, we show that conditioned media from high density L1 cultures was able to downregulate lips-15 even in L1 animals arrested at low density, and experiments using daf-22 mutant animals demonstrated that this effect is not mediated by the ascaroside family of signaling pheromones. Together, our data implicate a soluble signaling molecule in density sensing by L1 stage C. elegans, and provide guidance for design of experiments focused on early developmental gene regulation.
AÇIK ÖĞRETİM LİSESİ ÖĞRENCİLERİNİN DÜŞÜNME STİLLERİNİN İNCELENMESİ*
Authors: URAL Ozana , ESMER Elif 
Published: March 2018

İnsanın öğrenmesi üzerinde etkisi
olan bireysel farklılıklar içinde düşünme stilleri de yer almaktadır.
Öğrenenlerin düşünme stilleri çoğunlukla örgün eğitim sisteminde yer alanlar
üzerinde çalışılmıştır. Bu çalışmada açık lise öğrenenlerinin düşünme stilleri
ortaya konmuş ve bu stiller yaş ile cinsiyet değişkenine göre ele alınmıştır.
Araştırma, tarama modeline uygun ve betimsel nitelikte bir araştırmadır.
Çalışma grubunu 2016-2017 eğitim öğretim yılında İstanbul’da Tuzla Halk Eğitim
Merkezine Açık Öğretim Lisesine kayıt olan ve kayıt yenileme işlemleri için
başvuran 70 katılımcı oluşturmaktadır. Çalışmada, veri toplamak amacıyla
Stenberg ve Wagner tarafından geliştirilen ve Buluş (2006) tarafından Türkçeye
uyarlanan “Düşünme Stili Ölçeği” kullanılmıştır. Analizler sonucunda
öğrenenlerin düşünme stilleri belirlenmiştir. Çalışma bulguları açık öğretim
lisesi öğrencilerinin en fazla sırasıyla liberal, muhafazakâr ve hiyerarşik
stilleri kullandıklarını göstermektedir. Sonuç olarak, açık öğretim lisesi
öğrencilerinin eğitimden daha fazla yararlanması “bağımsız öğrenme”
becerilerini kazanmalarıyla ilintili düşünülmektedir. Bağımsız öğrenme
becerisini destekleyecek uygun düşünme stillerinin öğrencilere verilmesi
önerilmektedir.

&nbsp;
Prediction of adult-onset bronchial asthma in patients with metabolic syndrom in actual practice
Authors: Kosmynina M A , Kupaev V I 
Published: March 2018

Aim. Adult asthma diagnosis optimization for patients with metabolic syndrome using prognostic methods.
Methods. The study included 46 patients with metabolic syndrome. Out of them, at the time of the study 31 subjects suffered from adult-onset bronchial asthma. All participants of the study had a history and complaints collected, and a clinical examination performed. Spirometry was used to assess the severity of bronchial obstruction syndrome. To assess the severity of metabolic syndrome components, glucose and fasting insulin concentrations, and lipid profile were determined, the homeostasis index of insulin resistance was calculated. Also in all participants the concentrations of leptin and endothelin-1 in the serum were determined.
Results. Risk of adult-onset bronchial asthma in a typical patient with metabolic syndrome spikes with maximal blood pressure higher than 154/90 mm Hg, and immunoglobulin E and leptin level higher than 33 ME/ml and 3.7 ng/ml, respectively. Blood pressure level affects adult-onset bronchial asthma pathogenesis only in combination with other metabolic syndrome components. Immunoglobulin E-mediated reactions play an important role in the pathogenesis of adult-onset bronchial asthma, and leptin acts as a regulator of pathogenetic mechanism.
Conclusion. Development of adult-onset bronchial asthma in patients with metabolic syndrome may be predicted on the basis of various variables; according to our data, those variables include maximum systolic and diastolic blood pressure levels, and levels of immunoglobulin E and leptin.
Prevalence and risk factors for pelvic organ prolapse in female citizens of Baku
Authors: Askerova M Sh , Rzakulieva L M 
Published: March 2018

Aim. Study of prevalence and risk factors of pelvic organ prolapse in females in Baku.
Methods. Statistical observation unit was a woman aged 45-74 years. The sample size (710 women) was determined taking into account probable prevalence of pelvic organ prolapse (20% according to literature) and margin of error (3%). All women were invited to maternity welfare centre, and a thorough examination was performed after their written consent was obtained.
Results. The proportion of women aged 45-49, 50-54, 55-59, 60-64, 65-69, and 70-74 years was 26.5±1.7, 24.9±1.6, 23.1±1.6, 10.9±1.2, 8.2±1.0 and 6.4±0.9%, respectively. Prevalence of obesity in the named groups was 31.9, 34.5, 35.4, 36.4, 27.8 and 34.8%. Proportion of women with secondary and specialized secondary education was 58.5, 58.8, 53.7, 51.9, 51.7 and 67.4% resepctively. Among women of the corresponding age groups, physical work was recorded in 47.9, 53.7, 59.8, 58.4, 13.8 and 17.4% of cases, respectively. In past medical history, no surgeries were observed in 68.1, 77.4, 73.2, 77.9, 84.5 and 84.8% of cases, resepectively. Some women had no labour in past medical history (2.1, 2.3, 2.5, 2.6, 3.5 and 4.3% in the same age groups). Statistically significantly prevalence of pelvic organ prolapse increases among those aged 60 years and older (51.6±3.6% at age 45-49 years and ≥76.6±4.8% at age 60 years and older, р=0.001), with a body mass index less than 25.0 and more than 30 kg/м2 (69.7±3.3 and 66.7±3.0%, р=0.01), with high parity and remarkable family history (63.0±2.6, р=0.01), severe connective tissue dysplasia (72.6±2.5%, р=0.001), in postmenopausal period (63.8±2.0%, р=0.01), and depending on education level (88.0±2.4% among those with pre-secondary education: р=0.001). Relative risk of pelvic organ prolapse in the population of Baku is lower compared to the literature data in the background of obesity, but is higher in the background of positive family history and depending on the amount of deliveries (p=0.05).
Conclusion. In Baku 59.9±1.8% of women aged 45-75 years have pelvic organ prolapse of different severity, incomplete uterine and vaginal prolapse are more prevalent (41.3±1.8 per 100 women); prevalence of pelvic organ prolapse is higher in women aged 60 years or older compared to those aged 45-49 (76.6±4.8% vs 51.6±3.6%, р=0.001).
Presence of metabolic syndrome does not influence intima-media thickness and interadventitial diameter of main arteries in patients with type 2 diabetes mellitus
Authors: Rzaeva R A 
Published: March 2018

Aim. To evaluate intima-media thickness, interadventitial diameter of common carotid arteries and their ratio in patients with type 2 diabetes mellitus as well as in combination with metabolic syndrome, previously not receiving statins.
Methods. The results of Doppler ultrasound of common carotid arteries of 233 patients were analyzed. 73 of them were diagnosed with type 2 diabetes (49 males, 24 females, average age 59.2±9.13 years), 74 - in combination with metabolic syndrome (38 males, 36 females, average age 61.38±9.16 years), and 86 did not have neither type 2 diabetes nor metabolic syndrome (52 males and 34 females, average age 58.99±7.23 years). For variables with normal distribution, mean value (M) and error of mean (m) were used, and when comparing nonparametric parameters, distribution in contingency table and χ2 was used.
Results. Mean values of intima-media thickness of common carotid arteries and the ratio of intima-media thickness to interadventitial diameter were significantly higher (p <0.05), and interadventitial diameter was significantly lower (p <0.05) in the subgroups of patients with type 2 diabetes alone and in combination with metabolic syndrome compared to patients without these diseases. Significantly more frequently the cases of increased intima-media thickness and decreased interadventitial diameter of common carotid arteries were revealed on both sides in the subgroups with type 2 diabetes alone and combined with metabolic syndrome (p <0.001), that resulted in increased ratio of intima-media thickness to interadventitial diameter being indicative of general increase of arterial wall stiffness and decreased ability to compensatory remodeling in these categories of patients.
Conclusion. In patients with type 2 diabetes mellitus and its combination with metabolic syndrome previously not receiving statins, the values of intima-media thickness, interadventitial diameter and their ratio statistically significantly differ frome those in patients without type 2 diabetes and metabolic syndrome; the presence of metabolic syndrome does not influence values of intima-media thickness, interadventitial diameter and their ratio in patients with type 2 diabetes mellitus.
Antiimmunosuppressive action of 3d-metal gluconates in experimental immunodeficiency
Authors: Knyazeva O A , Urazaeva S I , Konkina I G , Saptarova L M , Gazdalieva L M , Murinov Yu I 
Published: March 2018

Aim. Evaluation of the effect of 3d-metal gluconates on complement-fixing function of immunoglobulin G and functional activity of complement.
Methods. The study was conducted in vivo on 2.5-3 month-old white laboratory mice weighing 25-28 g with secondary immunodeficiency, which was induced by a single intraperitoneal injection of cyclophosphamide, as well as in vitro in a test system using sensitized sheep erythrocytes. Immunological studies were performed in intact animals, and before and after the administration of Mn, Co, Cu, and Zn gluconates to mice with induced immunodeficiency. The content of immunoglobulin G and its complexes with subcomponent of the complement first component C1q was determined in serum by ELISA using specific monoclonal antibodies.
Results. Two-week oral administration of 3d-metal gluconates (Mn, Co, Cu, Zn) in a dose of 1/10 LD50 to immunodeficient mice was shown to cause a significant increase in the level of immunoglobulin G and its complexes with C1q. The greatest increase in concentration was observed with the introduction of zinc gluconate. Also by means of sensitized sheep erythrocytes in vitro, cobalt and, to a lesser extent, manganese gluconates were shown to increase the functional activity of C1q.
Conclusion. 3d-metal gluconates (Mn, Co, Cu, Zn) demonstrate immunocorrecting properties: increase the content of immunoglobulin G and its complexes with C1q, significantly decreasing as a result of cyclophosphamide effect; cobalt and manganese gluconates have a stimulating effect on the functional activity of complement by its classical pathway, which indicates different mechanisms of immunocorrection action of studied metal gluconates and requires further studies.
The first experience of the use of two-fraction adaptive intracavitary/interstitial brachytherapy in the treatment of cervical cancer
Authors: Isaev I G , Akperov K S , Guliev E G , Alieva N R , Alieva N S 
Published: March 2018

Aim. The study of the results of chemoradiotherapy for cervical cancer with the use of two-fraction brachytherapy.
Methods. The article presents analysis of the examination and treatment results of 17 patients with IIB-IIIB stage cervical cancer. The average age was 51±4.6 years (44 to 62 years). External beam radiotherapy was performed with single boost dose of 1.8 Gy to total dose of 45 Gy. Also the patients received 40 mg/m2 of weekly cisplatin. Intracavitary/interstitial high dose-rate brachytherapy with insertion of parametrial needles consisted of two weekly fractions of 10.0 Gy.
Results. Due to the use of interstitial needles the average dose was 82.2 Gy when recalculated to classical 2 Gy fractions. The median follow up was 16±3,2 months. The used radiotherapy modality for cervical cancer allowed achieving complete tumor involution in 16 (94.1%) patients and partial involution only in 1 (5.9%) case. All females had favorable tolerance and received the entire regimen of planned radiation.
Conclusion. The first experience of the use of concurrent chemoradiotherapy for locally advanced cervical cancer with external beam radiotherapy, two-fraction intracavitary/interstitial adaptive brachytherapy with single boost dose of 10 Gy and 5 weekly infusions of 40 mg/m2 of cisplatin showed high probability of complete and partial tumor response rate with favorable tolerance and acceptable incidence and severity of toxicity.