bluuebunny/crossref_metadata_2025_split huggingface dataset:
(131) SHAEER’S CAVERNOTOME: IMPLANTATION OF A FULL-SIZE INFLATABLE PROSTHESIS IN POST-PRIAPISM FIBROSIS
Authors: Shaeer O 
Published: December 2024

Abstract

Introduction
Implantation of a penile prosthesis in cases of corporeal fibrosis is a challenging procedure. Cavernotomes aid excavation of fibrous tissue in scarred corporal bodies. However, in many cases, the track established -with risk and difficulty- barely suffices for a narrow base inflatable or girth-9 malleable rods. The patient may have this exchanged with a full-size implant after several months, in another surgery. Shaeer’s Cavernotome is a corer, that cores out and grinds fibrous tissue in gentle rotatory movements rather than forceful forward thrusting. The process is therefore safer, and with lower risk of perforation. By choosing the maximum size of Shaeer’s cavernotome (6-13 Hegar), a track wide enough for full-size cylinder – rather than down-sized cylinders - can be established in one pass.

Objective
To demonstrate coring the scarred corpora cavernosa using Shaeer’s Cavernotome in cases of post-priapism cavernous fibrosis, enabling the implantation of a regular size inflatable implant.

Methods
Surgery was performed in 11 cases of post-priapism fibrosis, average duration post-priapism being 9.7 months +/−3. Incision was penoscrotal. Dilatation with blunt dilators failed. Corpora cavernosa and crura were fully excavated using Shaeer’s cavernotome, followed by dilatation of the track up to the maximum possible Hegar size with blunt dilators.

Results
Excavation succeeded up to size 13.5 Hegar in 7 cases and up to size 12.5 in 4 cases. One proximal crossing over occurred. No perforations were encountered. Three-piece inflatable penile prosthesis was implanted in all cases, with regular cylinders rather than down-sized. Average operative time was 65 minutes +/−12.2.

Conclusions
Shaeer’s Cavernotome renders penile prosthesis implantation in fibrotic cases safer and easier, and enables implantation of regular sized inflatable cylinders rather than down-sized ones.

Disclosure
No.
(132) GELATIN SPONGE (GELFOAM®) AS A HEMOSTAT IN PENILE PROSTHESIS IMPLANTATION
Authors: Mahmoud O 
Published: December 2024

Abstract

Introduction
Gelfoam® Sterile Compressed Sponge is a hemostatic that is directly applied to bleeding surfaces. This cost-effective hemostatic agent is prepared from purified porcine skin, Gelatin granules and Water for Injection. It is water insoluble, however is completely absorbed within 4-6 weeks with minimal scar formation. Gelfoam is available sterile for intra-operative use, and is applied in a multitude of surgical specialties.

Objective
In this work, we demonstrate for the first time the of Gelfoam to minimize the risk of bleeding in penile prosthesis implantation.

Methods
Eight cases received a three-piece inflatable implant (Rigicon Infla10®) through a peno-scrotal incision. Following cylinder insertion, corporotomies were closed by tying the stay sutures rather than water-tight sewing. Gelfoam was soaked in antibiotic-supplemented saline. Air bubbles were squeezed out followed by soaking. Gelfoam was then applied to the corporotomies, pump space and entry rout to the reservoir space. It was secured over the corporotomies by closing a pre-fashioned layer of Buck’s fascia. A suction drain was inserted. Mummy wrap was not used. Drain output was monitored and complications recorded.

Results
In two cases, drain output was an average of 80 cc’s in the first 24 hours, then 20 cc’s in the following 24 hours. However, in 6 cases, drain output was an average of 18 cc’s in the first 24 hours, mostly sero-sanguinous, then none in the following 24 hours. No cases of hematoma formation, infection, foreign body reaction, mass formation or hypersensitivity reaction were encountered.

Conclusions
The initial results of the current small case series demonstrate that Gelfoam is well-tolerated in penile surgeries, with possible value at minimizing post-operative bleeding, encouraging a multi-center larger study. Applying Gelfoam to the closed corporotomies, pump and reservoir spaces may help reduce the risk of bleeding, upon penile prosthesis implantation.

Disclosure
No.
(149) NEW FINDINGS REGARDING PERIOPERATIVE INFLATABLE PENILE PROSTHESIS ANTIMICROBIAL PROPHYLAXIS PATTERNS FROM A LARGE MULTINATIONAL COLLABORATION
Authors: Hammad MAM , Azad B , Gross MS , Swerdloff D , Miller J , Abou Chawareb E , Alkhayal A , Alrabeeah KA , Andrianne R , Burnett AL , Gross K , Hatzichristodoulou G , Lentz A , Osmonov D , Jones A , Modgil V , Perito P , Hotaling JM , Park SH , Pearce I , Sadeghi-Nejad H , Sempels M , Suarez-Sarmiento Jr. A , Van Renterghem K , Warner JN , Ziegelmann M , Hsieh TC , Jenkins L , Jones J , Simhan J , Yafi FA ,   on behalf of the PUMP (Prosthetic Urology Multi-institutional Partnership) collaborators, Barham DW 
Published: December 2024

Abstract

Introduction
Inflatable penile prosthesis (IPP) surgery is a well-established treatment for erectile dysfunction (ED). There is little information in the literature regarding the utilization of perioperative antimicrobial prophylaxis in primary and revision IPP surgeries.

Objective
We investigated the patterns of perioperative antimicrobial prophylaxis among a large multinational cohort of primary and revision IPP surgeries.

Methods
We conducted a retrospective analysis of 5400 patients (4187 primary IPP patients and 849 revision IPP patients) from our Prosthetic Urology Multi-Institutional Partnership (PUMP) institutions. Usage data for intravenous (IV), preoperative oral, and postoperative oral antimicrobials were analyzed. We specifically assessed patient profiles, antimicrobial selection, and antimicrobial duration. Multivariate statistical analyses were conducted to identify significant variations between primary and revision surgeries.

Results
For patients undergoing primary IPP placement, 81.9% received IV antibiotics for &lt;24 hours whereas 18.1% received IV antibiotics for &gt;24 hours. Preoperative oral antimicrobials were used in 59.4% of patients and 99.4% received postoperative oral antimicrobials. The overall infection rate for primary implants was 2%. Notably, quinolone administration shows a higher postoperative infection rate (11.4%) compared to gentamicin (1.9%), cephalosporin (0%), and vancomycin (1.0%). Multivariable regression analysis identifies factors such as a history of infection, diabetes, and priapism as predictors for postoperative infections. Furthermore, the study finds that perioperative antifungal use is associated with a decreased risk of infection.

Conclusions
This study provides valuable insights into the patterns of perioperative antimicrobial prophylaxis. Duration, type, and route of antibiotics given preoperatively or postoperatively do not affect postoperative infection rates among high volume prosthetic urologists. Giving IV antibiotics for more than 24 hours does not affect postoperative infection. Perioperative antifungals are a protective factor.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: Coloplast, Clarus Therapeutics, Antares Pharma, Acerus.
(180) VIRTUAL REALITY AND PORNOGRAPHY: THE IMPACT OF IMMERSIVE EFFECTS ON PORNOGRAPHY CONSUMPTION
Authors: Marques JM , Scanavino MDT , Figueiredo CPM 
Published: December 2024

Abstract

Introduction
Virtual reality (VR) technology contributes by providing a useful approach to behavioral observation and methodological safety to improve ecological validity and offers a promising tool for sex therapy interventions. We still lack information about the impact of VR when used in pornography consumption, since this technology is too recent, but authors hypothesize about its stimulus effects of immersion in sexual arousal.

Objective
This study investigates the impact of VR pornography on sexual behavior and its potential clinical applications. We contribute to a present review of the effects of stimuli immersion in VR on pornography consumption and describe in a synthesis of studies this effect in diverse sexual response outcomes.

Methods
Following PRISMA guidelines, we designed a research strategy describing types of studies, participants, data collection and outcomes, and search in four electronic databases (Pubmed, EMBASE, PsycInfo and Scielo) and made a full-text screening process, and last, assess studies based on GRADE protocol.

Results
The search found 149 articles and 11 meet eligibility criteria. The review highlights the limited research on VR pornography. Synthesis shows that most studies focused on the impact of level of immersion on diverse sexual responses. The existing studies primarily focus on correlations between VR immersion and physiological arousal during pornography consumption. The most frequent sexual response was erectile response, sexual attraction, and subjective sexual arousal. Most of the studies presented a significant methodology limitations like samplse size, randomization and allocation which in assessment studies show an uncertain risk of bias.

Conclusions
The literature is scarce and need to improve their methodology, even though it already shows relevant data for sex therapy intervention in pornography related problems. From this perspective, it could be a technology to improve psychological sexual dysfunctions because due to the immersion effect that has a greater impact on sexual arousal. Even with studies been applied to treat sexual related problems, more feasibility tests are still needed. On the other perspective, studies show concern about the use of VR in pornography consumption. Even though VR is not as widely consumed at domestic situations as other forms of pornography, its higher impact on sexual arousal due to level of immersion in virtual environment could worsen the impact of problematic pornography behavior. Further research on VR’s therapeutic applications and potential risks is crucial.

Disclosure
No.
(185) MEDICAL KNOWLEDGE AND PREJUDICE FROM THE PERSPECTIVE OF ANDROGENIC ANABOLIC STEROID USERS
Authors: Camara L , Freire M 
Published: December 2024

Abstract

Introduction
The abuse of androgenic anabolic steroids (AAS) has been increasing over the years, with prevalence rates reaching 6% among men and 3% among women in the general population. However, in specific groups such as recreational strength training enthusiasts, bodybuilders, and athletes from various sports, these figures can exceed an alarming 30%. Consequently, many medical societies and sports organizations consider AAS abuse a significant public health issue. This critical situation is further exacerbated by users who seek information from non-scientific (empirical) sources, the lack of adequate medical training on the subject, and societal prejudice. This prejudice can lead users to conceal their use or can manifest in the medical community through stigmatizing campaigns and refusal to provide clinical care. Enhancing medical knowledge is essential for the effective care and guidance of individuals using AAS, and can play a crucial role in mitigating the potential long-term harms associated with steroid abuse.

Objective
To conduct a survey among current and former users of AAS to delineate various characteristics of their abuse profiles. The survey includes specific questions related to the topic of interest, such as the users perception of medical knowledge and the prejudices they encounter during healthcare interactions.

Methods
An entirely anonymous survey was conducted using Google Forms, comprising 50 questions to delineate the profile of AAS abuse among Brazilian users and former users. The survey, promoted by various health professionals on social media platforms (Instagram, Facebook, Twitter) and WhatsApp groups, is ongoing. It includes a term of free and informed consent and does not require any personal user data, thereby ensuring that anonymity cannot be compromised in any of the responses. Subsequently, the data were transferred to analysis software and stored in a research database.

Results
Partial data from 917 respondents indicate that 9.7% believe doctors have no knowledge about AAS, 68.8% believe their knowledge is insufficient, 15% consider it good, and only 6.5% believe it is outstanding. Additionally, outside of medical consultations, 64.6% have witnessed prejudice from doctors regarding AAS use, while only 9.8% have never witnessed it. Notably, 25.6% of respondents declared they never reported AAS use to any doctors. Among those who reported AAS use during medical consultations, 27% received a comprehensive and positive response from the doctor, 34.1% received a poor response, 14.5% did not report use, and 24.3% have never been to a doctor.

Conclusions
The analyzed data indicate that, according to the perspectives of AAS users and ex-users, doctors often lack adequate knowledge, exhibit prejudice, or respond inappropriately when reports of use are mentioned during consultations.

Disclosure
No.
(188) CAUSAL ASSOCIATIONS BETWEEN PROSTATE DISEASES, RENAL DISEASES, RENAL FUNCTION, AND ERECTILE DYSFUNCTION RISK: A 2-SAMPLE MENDELIAN RANDOMIZATION STUDY
Authors: Dilixiati D , Lu J , Kadier K , Xie S , Azhati B , Xilifu R , Rexiati M 
Published: December 2024

Abstract

Introduction
Previous observational studies have found a potential link between prostate disease, particularly prostate cancer (PCa), and kidney disease, specifically chronic renal disease (CKD), in relation to erectile dysfunction (ED), yet the causal relationship between these factors remains uncertain.

Objective
The study sought to explore the potential causal association between prostate diseases, renal diseases, renal function, and risk of ED.

Methods
In this study, 5 analytical approaches were employed to explore the causal relationships between various prostate diseases (PCa and benign prostatic hyperplasia), renal diseases (CKD, immunoglobulin A nephropathy, membranous nephropathy, nephrotic syndrome, and kidney ureter calculi), as well as 8 renal function parameters, with regard to ED. All data pertaining to exposure and outcome factors were acquired from publicly accessible genome-wide association studies. The methods used encompassed inverse variance weighting, MR-Egger, weighted median, simple mode, and weighted mode residual sum and outlier techniques. The MR-Egger intercept test was utilized to assess pleiotropy, while Cochran’s Q statistic was employed to measure heterogeneity..

Results
Genetically predicted PCa demonstrated a causal association with an elevated risk of ED (odds ratio, 1.125; 95% confidence interval, 1.066-1.186; P &lt; .0001). However, no compelling evidence was found to support associations between genetically determined benign prostatic hyperplasia, CKD, immunoglobulin A nephropathy, membranous nephropathy, nephrotic syndrome, kidney ureter calculi, and the renal function parameters investigated, and the risk of ED.

Conclusions
The results of this study suggest a potential link between PCa and a higher risk of ED.

Disclosure
No.
(191) QUESTIONNAIRE: WHAT HELPS HETEROSEXUAL MALE SEXUAL AROUSAL?
Authors: Brendler J 
Published: December 2024

Abstract

Introduction
There is little research studying the emotional factors and behaviors that cause erection (function), as opposed to the number of studies on the organic factors that cause erection and erectile dysfunction. The results of applying the questionnaire can help healthy men and men with sexual dysfunction (which is very common, especially after 50 years of age.

Objective
To develop an auxiliary method to identify behaviors/factors that help male sexual arousal during sexual intercourse, for patients treated in clinical sexology, as well as to be applied to the general population.

Methods
The questionnaire consists of general items such as age, marital status, occupation (work and school), education. There are specific questions about sexuality, which list 41 behaviors/factors that can positively interfere with male emotional and/or physical sexual arousal; there is an open option, “other” (which allows you to write about other factors/behaviors), item 41. 20 listed items cover the man’s behavior and 14 cover the woman’s behavior, 6 items list the couple’s behavior. First, they choose up to 10 factors (out of 41 options) and then the 5 that most help with sexual arousal. The questionnaire was applied to two populations: men who were undergoing a private sexological consultation and among people who access websites with information about sexuality and sexual dysfunctions/problems.

Results
The questionnaire interested men when searching for scientific information (website www.terapiadosexo.med.br) about sexuality and its problems, being the first questionnaire for men most answered spontaneously. In men who consulted in clinical sexology, the questionnaire “mapped” the function of sexual arousal and the sexologist emphasized items that help erection to increase awareness of these behaviors and factors. Among dysfunctional men, he pointed out what helped erections in the past and may still work.

Conclusions
The questionnaire is useful as an auxiliary method in identifying behaviors/factors that support/help sexual arousal in both populations studied. In the general population (access via website) the findings can be used for sexual education and to disseminate what helps most men to have an erection. In clinical sexology, this identification aimed to guide the use of all behaviors and factors that help to initiate and maintain an erection, contributing to sexual health. The man was instructed to share the findings of his questionnaire with his sexual partner, improving intimacy and sexual life.

Disclosure
No.
(229) EFFECTIVENESS OF PROSTATE W-POINT MASSAGE IN IMPROVING SYMPTOMS, PROMOTING ERECTION AND SEXUAL PLEASURE
Authors: Wang Q 
Published: December 2024

Abstract

Introduction
Prostate disease will have frequent micturition, urgency, endless urine, urine waiting, urine dripping, night urine increase, low back pain, poor sleep and other symptoms, serious can affect sexual function and physical and mental health.

Objective
Explore the three main benefits of the w-spot prostate massage (named after its w-like massage path): improving symptoms of prostate disease (inflammation or hyperplasia), promoting penile erection, and sexual pleasure.

Methods
1. Methods: 300 men aged 30-50 years with similar symptoms of prostate diseases were randomly divided into 3 groups. The control group only took medicine, the experimental group only took w-point massage, the second group was treated with drugs and w-point massage. W-point massage is twice a week. After 4 weeks, the degree of symptom improvement was analyzed. 2. Methods: a total of 200 patients aged 30-50 years with prostate erectile dysfunction were randomly divided into two groups, the three groups were treated with w-point massage of the prostate twice a week. After 4 weeks, the improvement of erectile function in the two groups was analyzed. 3. Method of experiment and Investigation: 100 healthy men between 30-50 years old were selected as experiment group, and massaged at w-point of prostate twice a week for 4 weeks.

Results
The mean value of symptom improvement was 43.32% (p &lt; 0.05) in control group, 72.5% (p &lt; 0.05) in experimental group I and 85.48% (p &lt; 0.05) in experimental Group II. The erectile improvement rate was 36.8% (p &lt; 0.05) in the control group and 76.94% (p &lt; 0.05) in the experimental group. The incidence of sexual pleasure was 83.22% (p &lt; 0.05).

Conclusions
1. Prostate w-point massage is effective in improving the symptoms of prostate diseases, promoting erection (erectile dysfunction caused by prostate diseases) and sexual pleasure. 2. No massage is allowed in the acute stage of prostate attack, prostate tumor and basic diseases, such as heart disease, hypertension, etc.

Disclosure
No.
(250) THE EFFECTS OF PRETREATMENT WITH XIAFLEX ON PENILE CURVATURE CORRECTION WITH MANUAL MODELING DURING AND AFTER IPP PLACEMENT
Authors: Atwater BL , Gross MS , Madden-Fuentes RJ 
Published: December 2024

Abstract

Introduction
There are a variety of treatment modalities available to treat Peyronie’s disease (PD), including collagenase clostridium histolyticum (Xiaflex) injections. Patients with concomitant erectile dysfunction (ED) and PD are best served by insertion of an inflatable penile prosthesis (IPP) in order to adequately treat both conditions. Many PD patients may undergo other PD treatments, including Xiaflex, prior to IPP implantation. Little data exists regarding whether Xiaflex treatments prior to IPP placement influence changes in penile curvature during and after IPP surgery with manual modeling.

Objective
The primary objectives were assessing the impact of pre-treatment with Xiaflex on penile curvature immediately after IPP implantation and after manual modeling. The secondary objective was change in penile curvature postoperatively.

Methods
All IPP patients with known preoperative penile curvature with and without a history of Xiaflex injections undergoing IPP placement by a single surgeon from January 2017 to June 2023 were included in this IRB-approved (IRB 00031589) retrospective series. All patients had a 3-piece Coloplast Titan Touch IPP (Coloplast, Minneapolis, MN, USA) ranging 16-24 cm in length (mean 19.8 ± 1.9 cm) with 0-3 cm rear tips (mean 1.4 ± 0.9 cm). Goniometer was used to assess curvature during preoperative intracavernosal injection and duplex Doppler ultrasound, at multiple points intraoperatively, and postoperatively at 2 weeks, 6 weeks, and 6 months.

Results
Sixty-one patients were included. Preoperative curvature was 35° ± 17° (10° to 70°) for the Xiaflex cohort (n = 11) and 41° ± 15° (20° to 80°) for the Xiaflex naïve cohort (n = 50). At the time of IPP placement, patients previously treated with Xiaflex had a 19° ± 12° absolute reduction in penile curvatures, corresponding to a 45% ± 36% improvement, while Xiaflex naïve patients had a 20° ± 13° absolute reduction and 54% ± 23% improvement. Similar mean curvature reductions were seen with IPP placement regardless of curvature direction. There was little difference in change in curvature after modeling between the Xiaflex (11° ± 3°, 63% ± 23%) and Xiaflex naïve patients (14° ± 9°, 70% ± 20%). Interval assessments postoperatively were also comparable.

Conclusions
Preoperative treatment of PD with Xiaflex does not impede nor significantly improve curvature correction with IPP implantation and manual modeling. Similar changes in penile curvatures were seen in both groups regardless of curvature direction, modeling, or postoperative interval. In patients with severe PD, Xiaflex may be a useful tool to improve preoperative penile curvatures such that they may be more easily correctable with an IPP.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: Coloplast, MenMD.