bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revealing the coral habitat effect on benthopelagic fauna diversity in the Santa Maria di Leuca cold‐water coral province using different devices and Bayesian hierarchical modelling
Authors: Capezzuto Francesca , Calculli Crescenza , Carlucci Roberto , Carluccio Angela , Maiorano Porzia , Pollice Alessio , Sion Letizia , Tursi Angelo , D'Onghia Gianfranco 
Published: June 2019

Abstract

Data from two experimental longline surveys and two video inspections carried out in Santa Maria di Leuca cold‐water coral province (Mediterranean Sea) during spring–autumn 2010 were used in order to compare the benthopelagic abundance and diversity between coral and non‐coral habitats and between different devices. The sampling was carried out in two types of habitat: a coral habitat with carbonate mounds and a non‐coral habitat characterized by intermound sea floor.
A Bayesian hierarchical modelling approach to accommodate factors influencing community assemblages was used considering the number of species, the Shannon–Wiener diversity index and the two most abundant species represented by the European conger (Conger conger) and blackbelly rosefish (Helicolenus dactylopterus).
A relevant effect of the habitat factor was observed for both the number of species and the diversity index, showing a higher species number and diversity index in the coral habitat than in the non‐coral habitat. Concerning the relevance of fixed effects from the model on the probability of observing non‐zero (positive) abundances, the devices considered, longline and baited lander, did not show different influence for either C. conger or H. dactylopterus. In the case of positive abundance, a relevant device effect was only observed for H. dactylopterus, showing higher abundances for longline than for baited lander. A habitat effect was detected, with positive abundances for both species in the coral habitat.
This study proves that structurally complex habitats generated by cold‐water corals influence the distribution and diversity of the benthopelagic fauna, and that the use of different devices can provide complementary useful results. Increased knowledge about the role of cold‐water corals in the associated benthopelagic fauna could lead to better conservation of one of the most important hot spots of biodiversity in the Mediterranean Sea.
Scalable synthesis and antibacterial evaluation of 2‐(3‐(N‐(substituted phenyl)sulfamoyl)ureido)benzothiazoles
Authors: Cheraiet Zinelaabidine , Meliani Saida , Nessaib Mounir , Hessainia Sihem , Boukhari Abbas , Djahoudi Abdelghani , Regainia Zine 
Published: June 2019

AbstractA new series of 2‐(3‐(N‐(substituted phenyl)sulfamoyl)ureido)benzothiazoles was synthesized via a one‐pot efficient and scalable method, involving the condensation of 2‐aminobenzothiazoles derivatives, substituted anilines, and chlorosulfonyl isocyanate. The products were obtained in good yield with a simple workup, and their structures were confirmed from their spectral analyses. The synthesized compounds were further screened for their antibacterial activity against Gram‐positive and Gram‐negative pathogenic strains. The molecules show promising activity in the MIC value range of 2–0.25 µg/ml against selected bacterial strains, especially against nonfermentative carbapenem‐resistant bacteria (Pseudo VIM‐2 and Acinetobacter baumanni).
A new video‐camera‐based visiometer system
Authors: Yu Zhibin , Wang Jingli , Liu Xulin , He Liu , Cai Xiaowei , Ruan Shunxian 
Published: June 2019

AbstractWe provide a novel design of atmosphere visibility measurement system with the contrast principle used in the naked eye visibility observation. The new digital photography visiometer system (DPVS), composed of a CCD camera and two identical targets, utilizes the contrast of dual targets to measure the visibility. Two operational modes are designed to enable the DPVS to accommodate the lighting conditions of the day and night. Two passive targets, black bodies, are employed for daytime visibility measurement, and two active lights, LED panels, are utilized for nighttime. The mathematical models of the dual targets for both daytime and nighttime are developed, and the sensitivity analysis shows the requirements of the hardware to achieve desired accuracy. The design of the target including the blackbody and the LED panel is briefly discussed, and the temperature dependence and stability of the LED panels are measured experimentally. Finally, the DPVS is compared with two commercial visibility devices, a forward scatter meter and a transmission meter for field validation. A 5‐day comparative experiment shows that the measurements of the DPVS generally well agree with those of the transmissometer and the forward scatter meter for visibility up to 15 km, and the relative bias of 87% of the DPVS measurements lies between −0.2 and 0.2.
Psychometric analysis of the repetitive behavior scale‐revised using confirmatory factor analysis in children with autism
Authors: Hooker Jessica L. , Dow Deanna , Morgan Lindee , Schatschneider Christopher , Wetherby Amy M. 
Published: June 2019

Research examining restricted and repetitive patterns of behavior or interests (RRB) in autism spectrum disorder (ASD) has increased our understanding of its contribution to diagnosis and its role in development. Advances in our knowledge of RRB are hindered by the inconsistencies in how RRB is measured. The present study examined the factor structure of the Repetitive Behavior Scale‐Revised (RBS‐R) in a sample of 350 children with ASD ages 2–9. Confirmatory factor analysis designed for items with categorical response types was implemented to examine six proposed structural models. The five‐factor model demonstrated the most parsimonious fit based on common overall fit indices that was further supported by examination of local model fit indicators, though, the four‐ and six‐factor models evidenced adequate‐to‐good fit as well. Examination of RRB factor score approaches indicated only minor differences between summed item subscale scores and extracted factor scores with regard to associations with diagnostic measures. All RRB subtypes demonstrated significant associations with cognitive functioning and adaptive behavior. Implications for future research validating the RBS‐R as a more extensive clinical measure of RRB in ASD are discussed. Autism Res 2019, 12: 1399–1410. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryRepetitive behaviors are one of the two main symptoms of autism spectrum disorder (ASD). To better understand the role of repetitive behaviors, we must establish effective ways of measuring them. This study assessed the measurement qualities of the Repetitive Behavior Scale‐Revised (RBS‐R) in a sample of 350 children with ASD ages 2–9. We found that the RBS‐R measures multiple types of repetitive behaviors and that these behaviors are related to thinking ability and independence.
Vitamin D attenuates myocardial ischemia–reperfusion injury by inhibiting inflammation via suppressing the RhoA/ROCK/NF‐ĸB pathway
Authors: Qian Xuesong , Zhu Minghui , Qian Weichun , Song Jiaxian 
Published: June 2019

AbstractThe aim of this study was to investigate the protective effects of vitamin D (VD) against myocardial ischemia–reperfusion (I/R) injury in hearts. An I/R injury model was induced by left coronary artery ligation in Sprague‐Dawley rats (in vivo) and Langendorff perfusion of isolated hearts (in vitro). The infarction areas were determined by triphenyltetrazolium chloride (TTC) staining. Changes in the ST segment, cardiac function, lactate dehydrogenase (LDH) activity, creatine kinase (CK) activity, inflammatory cytokine (interleukin‐6 (IL‐6), IL‐1β, and tumor necrosis factor‐α (TNF‐α)) levels and the RhoA/ROCK/NF‐ĸB pathway were tested in rats with I/R injury treated with or without VD. VD notably alleviated myocardial injury with decreased infarction areas and had a restorative effect on cardiac function, which was specifically manifested as a restored ST segment, increased myocardial contractility and increased coronary blood flow in the isolated hearts. The levels of CK and LDH were also suppressed by VD. In addition, VD significantly decreased the expression of inflammatory cytokines in rat sera and isolated hearts. The RhoA/ROCK/NF‐κB pathway in I/R‐injured rats was also obviously inhibited with VD treatment. The present study demonstrates that VD plays a protective role against myocardial injury by inhibiting inflammation through repressing the RhoA/ROCK/NF‐κB pathway.
The challenges of facilitating arts learning in home education
Authors: Burke Katie 
Published: June 2019

Home education, or home schooling, is a rapidly growing global educational phenomenon. Given the emphasis that educators, policy makers and researchers have placed upon the arts as an important element in a holistic education, the ways in which the growing home education community are facilitating arts learning warrants consideration. Facilitating quality arts learning has been found to be extremely challenging, especially for generalist classroom teachers who may not possess background learning across the range of arts subjects represented in most arts curricula. Revelations from this study on Australian home educating parents identifies a similar dilemma with the facilitation of arts learning in home contexts, and a significant proportion of the home educating participants acknowledged little to no educational or artistic training. In this project, an online survey was conducted to develop insights into the ways Australian home educators (n = 193) approach arts education, the challenges associated with facilitating arts learning and the strategies they employ in light of these challenges. The research highlights that, while home education is pedagogically unique and distinct from traditional classroom education, the challenges participants expressed regarding teaching in the arts aligned closely with those expressed by classroom teachers in wider research; however, the uniqueness of home education contexts means that support structures for classroom teachers are less helpful for home educators. Implications arising from the research are thus beneficial in understanding the nature of support that might be tailored for arts learning in home education.
Stereotactic body radiotherapy improves the survival of patients with oligometastatic non‐small cell lung cancer
Authors: Ouyang Wen , Yu Jing , Nuerjiang Shuake , Li Zhijun , Wang Dajiang , Wang Xiaoyong , Zhang Junhong , Xie Conghua 
Published: June 2019

AbstractPurposeThe aim of the study was to evaluate the efficacy and safety of stereotactic body radiotherapy (SBRT) for pulmonary lesions in oligometastatic non‐small cell lung cancer (NSCLC) patients, to explore prognostic factors of progression‐free survival (PFS) and overall survival (OS), to validate improved survival contributed by SBRT in oligometastatic NSCLC patients.Patients and methodsA total of 71 oligometastatic NSCLC patients with 86 pulmonary lesions treated with SBRT in our institute between 2012 and 2018 were included. Local control (LC), progression‐free survival (PFS), and overall survival (OS) were calculated using Kaplan‐Meier method. Prognostic factors of PFS and OS were analyzed using univariate and multivariate Cox analyses. Subgroup analyses were performed to investigate the impact of SBRT on PFS and OS during first line systemic treatment.ResultsAfter a median follow‐up of 17.6 months, 2‐year LC and OS rates were 82.6% and 55.3%, respectively. No grade 4 or more toxicities were observed. Multivariate analysis showed systemic treatment regimen before SBRT was an independent prognostic factor of PFS, but not for OS. Among this cohort, patients receiving first line target therapy could show a better PFS and OS than those undergoing first line chemotherapy (target therapy vs chemotherapy, PFS, 26.4 m vs 6.9 m; OS, 34.8 m vs 15.5 m).ConclusionsSBRT for pulmonary lesions was a feasible and tolerable option for oligometastatic NSCLC patients. Delivery of SBRT for pulmonary lesions improved outcomes of oligometastatic NSCLC patients. Finally, SBRT combined with first line target therapy might have optimal outcomes.
Prognostic impact of intraoperative peritoneal cytology in interval debulking surgery for pelvic high‐grade serous carcinoma
Authors: Kojima Naoki , Yoshida Hiroshi , Kuno Ikumi , Uehara Takashi , Uno Masaya , Ishikawa Mitsuya , Kato Tomoyasu 
Published: June 2019

AbstractBackground and ObjectivesThe aim of this study was to determine whether peritoneal washing cytology (PWC) during interval debulking surgery (IDS) could predict the prognosis of patients with pelvic high‐grade serous carcinoma (HGSC) achieving R0 status.MethodsBetween January 2007 and May 2018, 110 patients with ovarian/tubal/primary peritoneal HGSC received platinum‐based neo‐adjuvant chemotherapy, followed by IDS at National Cancer Center Hospital, Japan. All the patients achieved R0 debulking status, defined as no macroscopic residual tumor in the peritoneal cavity at the completion of IDS. PWC was performed before debulking during IDS. The survival outcomes were compared between the PWC‐positive and PWC‐negative groups.ResultsThe median progression free survival (PFS) for the entire cohort was 17 months (range, 5‐133 months). The median PFS for the PWC‐positive group was significantly shorter than that of the PWC‐negative group (16 vs 19 months, HR 2.04, 95% CI 1.22‐3.41, P‐value < 0.01). Increased risk of progression was observed on both univariate and multivariate analyses, including age and FIGO stage (HR 2.28; 95% CI 1.35‐3.84, P < 0.01).ConclusionsThe positive PWC during IDS was found to predict earlier disease recurrence in patients with pelvic HGSC achieving R0 status. As performing PWC during IDS becomes standard practice, prospective validation should be conducted in the future.
Audio‐driven emotional speech animation for interactive virtual characters
Authors: Charalambous Constantinos , Yumak Zerrin , van der Stappen A. Frank 
Published: June 2019

AbstractWe present a procedural audio‐driven speech animation method for interactive virtual characters. Given any audio with its respective speech transcript, we automatically generate lip‐synchronized speech animation that could drive any three‐dimensional virtual character. The realism of the animation is enhanced by studying the emotional features of the audio signal and its effect on mouth movements. We also propose a coarticulation model that takes into account various linguistic rules. The generated animation is configurable by the user by modifying the control parameters, such as viseme types, intensities, and coarticulation curves. We compare our approach against two lip‐synchronized speech animation generators. Our results show that our method surpasses them in terms of user preference.
Targeting PCNA with Peptide Mimetics for Therapeutic Purposes
Authors: Horsfall Aimee J. , Abell Andrew D. , Bruning John B. 
Published: June 2019

AbstractProliferating cell nuclear antigen (PCNA) is an excellent inhibition target to shut down highly proliferative cells and thereby develop a broad‐spectrum cancer therapeutic. It interacts with a wide variety of proteins through a conserved motif referred to as the PCNA‐interacting protein (PIP) box. There is large sequence diversity between high‐affinity PCNA binding partners, but with conservation of the binding structure—a well‐defined 310‐helix. Herein, all current PIP‐box peptides crystallised with human PCNA are collated to reveal common trends between binding structure and affinity. Key intra‐ and intermolecular hydrogen‐bonding networks that stabilise the 310‐helix of PIP‐box partners are highlighted and related back to the canonical PIP‐box motif. High correlation with the canonical PIP‐box sequence does not directly afford high affinity. Instead, we summarise key interactions that stabilise the binding structure that leads to enhanced PCNA binding affinity. These interactions also implicate the “non‐conserved” residues within the PIP‐box that have previously been overlooked. Such insights will allow a more directed approach to develop therapeutic PCNA inhibitors.
Novel Supramolecular Photocatalyst Based on Conjugation of Cucurbit[7]uril to Non‐Metallated Porphyrin for Electrophotocatalytic Hydrogen Generation from Water Splitting
Authors: Kumar Yogesh , Patil Bhushan , Khaligh Aisan , Hadi Seyed E. , Uyar Tamer , Tuncel Dönüs 
Published: June 2019

AbstractThe front cover artwork for Issue 13/2019 is provided by Tuncel and co‐workers at UNAM and the Chemistry Department of Bilkent University (Turkey). The image shows solar energy promoted photoelectrocatalytic water splitting for hydrogen generation using a supramolecular photocatalyst. See the Communication itself at https://doi.org/10.1002/cctc.201900144.
Ranking Oxidant Sensitiveness: A Guide for Synthetic Utility
Authors: Dallaston Madeleine A. , Bettencourt Christian J. , Chow Sharon , Gebhardt Joshua , Spangler Jordan , Johnston Martin R. , Wall Craig , Brusnahan Jason S. , Williams Craig M. 
Published: June 2019

AbstractCommon oxidants used in chemical synthesis, including newly developed perruthenates, were evaluated in the context of understanding (and better appreciating) the sensitiveness and associated potential hazards of these reagents. Analysis using sealed cell differential scanning calorimetry (scDSC) facilitated Yoshida correlations, which were compared to impact sensitiveness and electrostatic discharge experiments (ESD), that enabled sensitiveness ranking. Methyltriphenylphoshonium perruthenate (MTP3, 8), isoamyltriphenylphosphonium perruthenate (ATP3, 7) and tetraphenylphosphonium perruthenate (TP3, 9) were found to be the most sensitive followed by 2‐iodoxybenzoic acid (IBX, 2) and benzoyl peroxide (BPO, 10), whereas the most benign were observed to be Oxone (12), manganese dioxide (MnO2, 13), and N‐bromosuccinimide (NBS, 17).
Nivolumab treatment beyond RECIST‐defined progression in recurrent or metastatic squamous cell carcinoma of the head and neck in CheckMate 141: A subgroup analysis of a randomized phase 3 clinical trial
Authors: Haddad Robert , Concha‐Benavente Fernando , Blumenschein George , Fayette Jerome , Guigay Joel , Colevas A. Dimitrios , Licitra Lisa , Kasper Stefan , Vokes Everett E. , Worden Francis , Saba Nabil F. , Tahara Makoto , Jayaprakash Vijayvel , Lynch Mark , Li Li , Gillison Maura L. , Harrington Kevin J. , Ferris Robert L. 
Published: June 2019

BackgroundResponse patterns with immune checkpoint inhibitors may be different from those with chemotherapy. Therefore, assessment of response to immunotherapy with the Response Evaluation Criteria in Solid Tumors (RECIST), version 1.1, could result in premature treatment termination. The randomized, open‐label, phase 3 CheckMate 141 trial (NCT02105636), which evaluated nivolumab in recurrent/metastatic squamous cell carcinoma of the head and neck after platinum therapy, allowed treatment beyond first RECIST‐defined progression (TBP) according to protocol‐specified criteria.MethodsIn CheckMate 141, patients with RECIST‐defined progression who had a stable performance status and demonstrated clinical benefit without rapid disease progression were permitted to receive TBP with nivolumab at 3 mg/kg every 2 weeks until further progression, which was defined as an additional ≥10% increase in tumor volume. This post hoc analysis evaluated outcomes for patients who received TBP with nivolumab.ResultsOf 240 patients randomized to nivolumab, 146 experienced RECIST‐defined progression. Sixty‐two of these patients received TBP, and 84 discontinued treatment (no TBP). Among the 60 TBP patients evaluable for response, 15 (25%) had no change in their tumor burden, and 15 (25%) had reductions in target lesion size; 3 patients (5%) had reductions >30%. The median overall survival among TBP patients was 12.7 months (95% confidence interval, 9.7‐14.6 months). No new safety signals were observed with TBP. Exploratory analyses of immune cell biomarkers suggested a potential relationship with initial and TBP responses.ConclusionsTumor burden reduction was noted in a proportion of patients who received TBP with nivolumab in CheckMate 141. Additional research is warranted to identify factors predictive of a TBP benefit in this population.
Prevalence and predictors of probable depression in prostate cancer survivors
Authors: Erim Daniel O. , Bensen Jeannette T. , Mohler James L. , Fontham Elizabeth T. H. , Song Lixin , Farnan Laura , Delacroix Scott E. , Peters Edward S. , Erim Theodora N. , Chen Ronald C. , Gaynes Bradley N. 
Published: June 2019

BackgroundThe early diagnosis and treatment of depression are cancer care priorities. These priorities are critical for prostate cancer survivors because men rarely seek mental health care. However, little is known about the epidemiology of depression in this patient population. The goal of this study was to describe the prevalence and predictors of probable depression in prostate cancer survivors.MethodsThe data were from a population‐based cohort of North Carolinian prostate cancer survivors who were enrolled from 2004 to 2007 in the North Carolina–Louisiana Prostate Cancer Project (n = 1031) and were prospectively followed annually from 2008 to 2011 in the Health Care Access and Prostate Cancer Treatment in North Carolina study (n = 805). Generalized estimating equations were used to evaluate an indicator of probable depression (Short Form 12 mental composite score ≤48.9; measured at enrollment and during the annual follow‐up) as a function of individual‐level characteristics within the longitudinal data set.ResultsThe prevalence of probable depression fell from 38% in the year of the cancer diagnosis to 20% 6 to 7 years later. Risk factors for probable depression throughout the study were African American race, unemployment, low annual income, younger age, recency of cancer diagnosis, past depression, comorbidities, treatment decisional regret, and nonadherence to exercise recommendations.ConclusionsDepression is a major challenge for prostate cancer survivors, particularly in the first 5 years after the cancer diagnosis. To the authors' knowledge, this is the first study to demonstrate an association between treatment decisional regret and probable depression.
On‐Surface Photochemistry of Pre‐Ordered 1‐Methyl‐2‐phenyl‐acetylenes: C‐H Bond Activation and Intermolecular Coupling on Highly Oriented Pyrolytic Graphite
Authors: Colazzo Luciano , Casarin Maurizio , Sambi Mauro , Sedona Francesco 
Published: June 2019

AbstractIn this contribution we report on light‐induced metal‐free coupling of propynylbenzene molecular units on highly oriented pyrolytic graphite. The reaction occurs within the self‐assembled monolayer and leads to the generation of covalently coupled 1,5‐hexadiyne and para‐terphenyl derivatives under topological control. Such photochemical uncatalysed pathway represents an original approach in the field of topological C−C coupling at the solid/liquid interface and provides new insight into the low temperature formation of aromatic compounds at the surface of carbonaceous supports.