bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous MR-guided whole-gland prostate cancer cryoablation: safety considerations and oncologic results in 30 consecutive patients
Authors: De Marini Pierre , Cazzato Roberto Luigi , Garnon Julien , Tricard Thibault , Koch Guillaume , Tsoumakidou Georgia , Ramamurthy Nitin , Lang Hervé , Gangi Afshin 
Published: March 2019

Objective:
To assess the safety and oncological efficacy of percutaneous MR-guided whole-gland prostate cancer (PCa) cryoablation (CA).

Methods and materials:
Between July 2009 and January 2018, 30 patients (mean age 72.9 ± 5.13 years) with histologically proven, organ-confined (≤ T2cN0M0), predominantly low/intermediate-risk PCa (median Gleason score 7; mean prostate specific antigen 6.05 ± 3.74 ng ml−1 ) underwent MR-guided whole-gland CA. Patients were selected on the basis of prior pelvic radiotherapy (n = 16; 12 for previous PCa), or contra indication/refusal of surgery or radiotherapy. Complications, local progression-free survival (LPFS) and overall survival (OS) were retrospectively investigated.

Results:
Eighteen [60%] patients reported procedure-related complications: 5/18 [28%] needed surgical/interventional treatments and 13 [72%] conservative or pharmacological treatment. Eleven [73%] complications were noted in the first 15 patients and 7 [47%] in the last 15 patients (p = 0.26). Mean nadir prostate specific antigen was 0.24 ± 1.5 ng ml−1 (mean follow-up 3.8 years; range: 2 – 2915 days). Seven [23%] patients developed histologically proven local progression (mean time to recurrence 775 days, range: 172 – 2014). Mean clinical follow-up was 3.8 years (range 1–2915 days). LPFS was 92.0, 75.7 and 69.4 % at 1-, 3- and 5 year follow-up, respectively. For patients in salvage treatment, LPFS was 100%, 75%, and 75% at 1-, 3- and 5 year follow-up. OS was 100%, 94.4 and 88.5 % at 1-, 3- and 5 year follow-up respectively, with no patients dying from PCa.

Conclusion:
Whole-gland PCa CA offers good oncological efficacy, particularly in post-radiotherapy cases. Although the complication rate is significant, the majority is minor and is managed with conservative or pharmacologic management.

Advances in knowledge:
MRI-guided whole-gland prostate cancer cryoablation offers good oncological efficacy, particularly in post-radiotherapy cases with a contained complication rate.
Fibroblast growth factor-6 enhances CDK2 and MAKT expression in microvesicles derived from human stem cells extracted from exfoliated deciduous teeth
Authors: Othman Ahmed , Mubarak Rabab , Sabry Dina 
Published: March 2019

Background: Stem cells from human exfoliated deciduous teeth (SHEDs) are considered one of the most convenient sources of adult stem cells. This study aimed to examine the effect of fibroblast growth factor 6 (FGF-6) on SHEDs and evaluate CDK2 and MATK gene expression in SHED-derived microvesicles (MVs). SHEDs were cultured from deciduous teeth pulp. Methods: SHEDs were divided into two groups: the control group and test groups, with and without FGF-6 supplementation, respectively. After the third passage, SHED proliferation was assessed by MTT assay. MVs were purified and CDK2 and MATK gene expression was assessed by real time polymerase chain reaction. SHEDs were identified by their positivity for CD90 and CD73, and negativity for CD45 and CD34. Results: SHEDs proliferation in the test group was significantly higher than in the control group (P<0.001). mRNA from SHED-derived MVs from the test group exhibited a markedly elevated expression of CDK2 and MAKT, (P<0.002 and P<0.005, respectively) in comparison with those of the control group. FGF-6 enhanced the proliferation of SHEDs. Proliferation enhancement is favorable for the production of a large number of stem cells, which will then be beneficial for cell-based therapies. Conclusions: CDK2 and MAKT genes in SHED-derived MVs can be used as molecular biomarkers for SHED proliferation.
Evaluating the contribution of interdisciplinary obstetrics skills and drills emergency training
Authors: Hayes Catherine , Hinshaw Kim , Hogg Robert , Graham yitka 
Published: March 2019

Background High-fidelity simulation is integral to health professional training. The effect of interdisciplinary training on levels of confidence in obstetric emergencies is less well explored. Aim To evaluate the impact of a multidisciplinary training project in obstetric emergency skills and drills on the confidence of staff. Methods A mixed-methods approach was used to evaluate the self-reported confidence levels of obstetrics staff. A total of 69 staff voluntarily attended emergency skills and drills training with a birthing simulator manikin. The programme used four emergency scenarios that had potential for poor maternal outcomes. A debrief followed each scenario and confidence levels were self-reported before and after each training session. Findings There were significant (P<0.05) effects on teams' self-perceived confidence levels. Staff reported that training improved their knowledge and understanding of interdisciplinary roles, and improved capacity within and between professional disciplines. Conclusion This model is of significant use in interdisciplinary obstetric emergency care training. Training had a direct effect on the staff's perceived confidence and encouraged critical reflection on professional practice in emergency obstetrics.
Doujinshi and Comiket: A day of ‘hare’
Authors: McInerney Tara 
Published: March 2019

Abstract
Since 1975, the increasing success of Comiket (Comic Market) stands testament to the popularity of doujinshi in Japan. At first attracting only 700 visitors, Comiket now attracts roughly one million visitors yearly, with nine million doujinshi sold per market. Meiji University’s Yoshihiro Yonezawa Memorial Library is entirely dedicated to the collection and preservation of hundreds of thousands of fancomics – their status elevated to that of high cultural and historical worth, worthy of their own archive. Whilst doujinshi are now a valued commodity, seen as inextricable from the manga industry, they are still categorically illegal. Doujinshi (fan-comics) are hailed as the foundation of the Manga industry, supporting creative talent, craft tradition and financial revenue. There are many practical legal defenses for doujinshi that are widely agreed upon, a symbiosis that has been acknowledged by lawyers and academics, creators and fans alike. Even Japanese Prime Minister Shinzo Abe commented that doujinshi ‘operate in a different market’ to original manga, and therefore do not warrant litigation. These arguments sit well with Japanese lawyers, but if doujinshi have proven so beneficial to the Japanese comic industry, why are fan-comics shrouded in taboo in the West? Even before one attempts to sell a fan-comic, the sheer creation of them is culturally shameful – not a parody, but a soulless copy. In Japan there is a learning model of creating utsushi (replicas) that functions through applied copying, used in traditional crafts such as basket-weaving, lacquering and now, even manga (in the West we may liken it to rotelearning or embodied learning). In light of utsushi, I aim to examine the boundary between copying craft and copying ideas. I hope to explain the inextricability of learning Manga as a visual language with learning storytelling through reappropriation of archetypes and the folkloric tradition of the East. I aim to depict this cultural and cognitive dissonance between Japan and the West, this disagreement of exactly what constitutes a copy.
Goffman’s Frame Analysis, modality and comics
Authors: Davies Paul Fisher 
Published: March 2019

Abstract
This article explores how comics can ‘frame’ experience by instantiating borders in various ways, temporally, spatially and socially. It approaches ‘frame analysis’ in two senses: first, the ‘framing’ of comics in the sense of their nesting in bookended narrative structures, drawing attention to the hypotaxis inherent to graphic narrative, and highlighting parallels to the framing of experience in Goffman’s sense. Second, with a focus on the frame itself, the panel border: attending to how this can be used to signal the status of the material enclosed, that is, to modalize the narrative in ways parallel to those suggested by Goffman. The article will bring together Goffman’s social pragmatics and M. A. K. Halliday’s functional approach to multimodal texts, offering not only an approach to the reading of comics texts but also a method for comics creators to present imaginary, fictional, remembered and otherwise ‘framed’ experience. During the course of discussion, the article will also consider disruptions of framing, and transitions from frame to frame, both in the sense of panel-to-panel and from modality to modality.
Tempo de Leitura e Acurácia na Conversão Grafofonêmica na Relação entre Fluência e Compreensão Leitora / Reading Time and Accuracy in Grafophonic Conversion in the Relationship between Fluency and Reading Comprehension
Authors: Abreu Cristiane Vieira Costa , Guaresi Ronei 
Published: March 2019

Sustentado em pressupostos teóricos psicolinguísticos, no tocante ao processamento cognitivo da leitura, inclusive e especialmente por meio dos modelos Botton-up e Top-down e Dupla Rota e, ainda, em estudos de revisão de literatura que tratam da relação entre fluência e compreensão leitora, este estudo objetiva avaliar a relação entre fluência e compreensão leitora. Avaliou-se a fluência leitora por meio do tempo disponibilizado para a leitura oral e pelo critério precisão de conversão grafema-fonema e a compreensão leitora, mediante respostas escritas de questões abertas de compreensão do texto lido. Participam da pesquisa 191 estudantes do 4º ano do ensino fundamental, entre 9 e 13 anos, de ambos os sexos, de escolas pública e particular do interior da Bahia. Observamos, a partir de dados preliminares, uma correlação forte entre as duas variáveis estudadas, quanto menor o tempo de leitura maior a compreensão leitora e menor a ocorrência de trocas, omissões, repetições, adições e inversões de letras, silabas ou/e palavras na conversão grafofonêmica. Leitores mais fluentes usam, preferencialmente, a rota lexical e o modelo descendente. Leitores menos fluentes utilizam, preferencialmente, a rota fonológica e o modelo ascendente. Ao que parece, a falta de reconhecimento automatizado dos grafemas impõe maior custo de processamento cognitivo, ou seja, o processamento pelas vias fonológica e ascendente parece consumir a gama essencialmente limitada de recursos cognitivos da memória de trabalho, como consequência, restam poucos recursos cognitivos para acesso ao significado.
Avaliação das interações medicamentosas entre antihipertensivos e hipoglicemiantes orais / Evaluation of drug interactions between antihypertensive and oral hypoglycemic agents
Authors: Alves Natália Rodrigues , Menezes Paula Denise Lima de , Diniz Joaquim Alves , Souza Francisca Andreza Fernandes de , Carvalho Poliana Moreira de Medeiros , Tavares Sâmia Macedo Queiroz Mota Castellao 
Published: March 2019

As interações medicamentosas podem acontecer quando há o uso de dois ou mais medicamentos concomitantemente, ocasionado consequências clínicas que podem afetar a saúde do paciente. A partir destas interações a finalidade da terapia proposta pode não ser alcançada, causando muitas vezes ineficácia do tratamento. O objetivo deste trabalho foi avaliar as Interações Medicamentosas presentes nas prescrições médicas dos pacientes da Policlínica Tasso Jereissat portadores de Diabetes Mellitus e Hipertensão Arterial. Foi realizado uma entrevista individual com 22 pacientes da policlínica em forma de questionário, envolvendo indivíduos com idade entre 54 e 75 anos. O trabalho revelou que a maioria dos pacientes usavam 5 medicamentos ou mais, o que influenciou na ocorrência de Interações Medicamentosas. Os medicamentos mais frequentes foram Metformina e Losartana. Foram encontradas Interações Medicamentosas potenciais com relevâncias clínicas baixa, moderada e alta. A maioria das Interações Medicamentosas encontradas foram de relevância clínica Moderada. Entre os pares de Interações Medicamentosas mais frequentes, 61,54% foi entre Metformina e Hidroclorotiazida, resultando em hiperglicemia, intolerância a glicose e risco de acidose láctica. Foi observado que esse resultado se deve ao fato de 36% dos pacientes usarem Hidroclorotiazida e Metformina concomitantemente. A média de interações medicamentosas por prescrição foi de 0,60. O trabalho concluiu que quanto maior o número de medicamentos maiores são as chances de ocorrência de Interações Medicamentosas e que a terapia medicamentosa pode ser deficiente mesmo com o uso correto.
BAHASA MEDIA: ANALISA SENSITIVITAS GENDER DAN KONTESTASI KEKUASAAN
Authors: Witriani Witriani 
Published: March 2019

This paper discusses about media analysis especially on language news of the current issues in both electronic and printed media of Indonesia. Focus on the gender issues on the headline news of media, the writer analyzes various types of gender insensitivity among the media as being portraited in the titles especially for such criminal cases in which women were involved both as the victims and the doer or lawbreakers. It’s a library research, in which the writer focuses on certain cases to be analyzed and collects all related data to support the analysis. Since the object of the analysis is the title of various headlines news, the theoretical approaches here are theory of semiotic and representation. The research finds out that as being represented in the titles, some media are not quite sensitive in viewing various cases happened in the society, especially related to gender inequality. The media only focused on how to get a lot of audience attention but ignoring the effects on the readers. The bias news would essentially causes and strengthens myths which only bring such benefit to a certain interest especially the power or those who control the rule. The research also finds that the power relation between men and women in the public area also contribute in generating such bias statements or news, not only on the choice of words but also on angle and gender perspective. The bias news represents the bias society.
STRUKTUR WACANA RITUAL (Studi Kasus Ritual Selametan di Pesarean Gunung Kawi, Malang, Jawa Timur)
Authors: Nuryani Nuryani 
Published: March 2019

Rituals of selametan (celebrations of thanksgiving and / or to ask the blessingsand favours from the God, gods, or spirits) can be found at Pesarean Gunung Kawi, Malang, East Java. In this place, the ritual has some purposes. These can be known from the discourse that is spoken by modin or the leader of the ritual ceremony. The objective of this study is to describe the structure of the speech discourse in ritual of selametan. Data recordings which are obtained in the form of implementation of the ritual were transcribed. Based on the research and analysis, some results can be concluded. The views of the structure of language or the speech discourse, in selametan ritual are composed of invitation, solicitation/expectations, and statement sentences. The invitations appear in the early discourse, expectations appear in all parts of the discourse, while statements also appear in each section.
SIRI’ DAN PACCE DALAM EPISODE PERJALANAN SAWERIGADING KE TANAH CINA
Authors: Ram Aminuddin 
Published: March 2019

This paper deals with the so called siri’ and pacce which are the most important values in Buginese-Makassarese culture. The paper attempts to observe these two values as reflected in the episode of Sompe’na Sawerigading Lao ri Tanah Cina (Sawerigading’s Journey to Tanah Cina) which is one of the episodes of Lagaligo, the longest world literary work recognized by Unesco (United Nations, Educational, Social, and Cultural Organization) as a Memory of the World (MOW) in 2011. Siri’ and pacce, which are the core values of Buginese-Makassarese culture, function as a source of moral reference that strongly influences the way of thinking and behavior of Buginese-Makassarese people. The paper reveals that several characters in the story of Sompe’na Sawerigading Lao ri Tana Cina try to do their best to observe the two values in facing conflicts and challenges of life, but some of them fail. This is due to the fact that the implementation of siri’ and pacce may vary in accordance with one’s status, emotional and intellectual maturity as well as motivation. It is recommended that in order to reduce the destructive impacts of globalization and to minimize the deterioration of national identity and character there should be a holistic strategic policy and efforts taken both by the state and private institutions to seriously and continuously facilitate the transformation of noble values.
PRANATA MANGSA JAWA (Cermin Pengetahuan Kolektif Masyarakat Petani di Jawa)
Authors: Badrudin Ali 
Published: March 2019

The research studies the Javanese language in the context of it society. The main goal is to express the knowledge system and the thought patterns of the Javanese society, especially the Javanese farmers, in understanding their life and the world of their life. The steps of this research are: (1) collecting data, (2) analyzing data, and (3) presenting the research results. The analysis of the data finds the following results: (1) The language units classification pattern are analyzed grammatically; (2) the knowledge system and the collective thought of the Javanese society expressed in the pranata mangsa are as follows: (a) The uses of metaphor describes: the world/the earth, (parts of) human body, wind, sounds, finery, water, and family relationship; (b) The reasons of using the Kawi language in pranata mangsa are motivated by the intellectual values, the artistic values, aesthetic aspects, and common usage in the Javanese literature; and (c) In relation to pranata mangsa, the Javanese society has the concepts of the vertical and horizontal relationship, which cover: the concept of God, the world/the earth, time, and space. Through pranata mangsa, the farmers harmonizing themselves with the cosmos and the nature.
NILAI-NILAI KEHIDUPAN DALAM PUISI AL-MUTANABBI
Authors: Nurain Nurain 
Published: March 2019

This study assumes that literary works are not neutral or value-free works. Poetry which is the main object of this article carries not only aesthetic values but also personal and social life values, either directly attributed consciously by the poet him/herself or by the audiences. Poetry is one of the main ways to express feeling and imagination among the Arabs since the era of jahiliy (the days of ignorance). Therefore, a poet was highly hallowed and respected like a priest, spokesman, tribal chief, or even prophet. This phenomenon reached its peak in the Abbasid period due to the caliphs’ support. One of the great poets in the Abbasid period was Al-Mutanabbi. This paper examines his poems with the purpose to explore their literary values as well as their various life values using a pragmatic approach. From this study, the writer discovers a number of values, such as intellectual, religious, social, patriotic or heroic, and philosophical, in addition to the poetic aesthetic values in his works. These values are not free from the dynamics of Al-Mutanabbi’s life and his association as a court poet, mainly of Saif al-Daulah’s.
TELAAH SIMBOL DAN METAFOR: ANTARA TRANSENDENTALISME DAN “SUFISME SEKULER” DALAM KARYA RALPH WALDO EMERSON
Authors: Minderop Albertine 
Published: March 2019

The aim of this study is to show the essence of transcendentalism in the context of the "Divine Light" which is assessed through figurative language style (metaphors and symbols). The scope of research is the study of literature, such as essays, and style; from the point of Transcendentalism philosophy. The theory used is the science of literature -the concepts of figurative language. The point of view is philosophy of transcendentalism and Sufism. Stages in Sufism are Shari'a, congregations, nature, and ma'rifat. The results showed that Emerson’s essays called transcendentalism contains teachings as "Secular Sufism", focusing on human control efforts. In this case, Emerson Transcendentalism does not require any religious means, therefore he was called “Secular Sufism”; whereas the teachings of Sufism emphasizes the teachings of religion. Conclusion of the study is the benefit of achieving the "Light Divine," that is, a mental reform that produces "true happiness" and forms a "whole person."
MANIFESTASI WUJUD DAN MAKNA PRAGMATIK KEFATISAN BERBAHASA DALAM RANAH PENDIDIKAN
Authors: Rahardi R. Kunjana 
Published: March 2019

This research on phatic communion is aimed at describing the forms and the pragmatic meanings of phatic language in Indonesian society, especially in the educational domain. Based on its pragmatic meanings, the utterance in the educational domain can be categorized into five pragmatic meanings, namely (a) phatic function in utterances of acceptance, (b) phatic function in the form of utterances of rejection, (c) phatic function in the form of utterances of invitation, (d) phatic function in the form of utterances of thanking, and (e) phatic function in the form of utterance of greeting.
Suffering and Sacrifice
Authors: Wolf Sarah 
Published: March 2019

This article offers the argument that suffering (yisurin) in the Babylonian Talmud functions as a locus for the relationship between God and rabbinic Jews. Scholars of rabbinic martyrdom and asceticism have tended to claim that the Talmud's positive portrayal of suffering is a theodical apology for unexplained evil in the world. However, the article argues that the Talmud—in contrast to earlier rabbinic texts—presents suffering as spiritually relevant not primarily to justify preexisting suffering, but rather to develop a site at which to interpret information about an individual's spiritual status.The article draws on theories of sacrifice's structure and function, in conjunction with close analysis of rabbinic texts that relate suffering to sacrifice. The pericope at the core of the article's argument demonstrates a strikingly technical approach to the human experience of suffering, describing four examples of yisurin in which no real physical suffering occurs; in each instance the “victim” experiences extremely mild discomfort at most, and at the least barely registers an experience of inconvenience. Nonetheless, these experiences all qualify as “suffering,” and are thus still understood to bear indisputable soteriological import. Physical suffering in the Talmud is thus open for interpretation, yielding information about the status of the sufferer's spiritual self.Human suffering is viewed as religiously desirable in both late rabbinic and early Christian literatures. By developing an understanding of its hermeneutical function for the rabbis, this article helps to elucidate the value of suffering for rabbinic literature as a subset of late antique religious discourse.