bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of exercise training on cardiotoxicity and cardiac health outcomes in women with breast cancer undergoing anthracycline-containing chemotherapy: a study protocol for a randomized controlled trial.
Authors: Antunes Pedro , Esteves Dulce , Nunes Célia , Sampaio Francisco , Ascensão Antonio , Vilela Eduardo , Teixeira Madalena , Amarelo Anabela Leal , Joaquim Ana 
Published: May 2019

Abstract
Background: Anthracyclines are chemotherapeutic agents frequently used in breast cancer (BC) treatment. Although improving disease-free and overall survival, the use of anthracyclines is associated with a cumulative risk of cardiac toxicity. Preventive strategies to optimize cardiac health are needed and exercise is proposed as a potential non-pharmacological approach for counteracting of anthracycline-related cardiotoxicity (ARC). Most of the data on the effects of exercise to reduce ACT is from animal studies, with only a few studies with a limited number of patients indicating beneficial effects. To better understand the effectiveness of exercise in mitigation of ARC, clinical, real-world trials claim for a larger sample size and more accurate and valuable clinical biomarkers. In this study, we intend to include a large sample size and investigate cardiac function throughout serial measures of biomarkers and imaging techniques.
Methods: This protocol describes a two-armed prospective randomized controlled trial that will explore the cardioprotective effect of a structured exercise program in women with BC undergoing anthracycline-containing chemotherapy (ACT). Ninety adult women with early BC and with a therapeutic decision to receive ACT will be randomly assigned (1:1) to an intervention group or a control group. Patients allocated to the intervention group will perform a supervised exercise program three times per week, consisting of a combination of aerobic and resistance training with progressive intensity and volume, during the time period they received ACT. The control group will receive standard BC care. Primary outcomes related to cardiac (dys)function will be circulating N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, resting left ventricular (LV) longitudinal strain, and resting LV ejection fraction. Secondary outcomes will include the assessment of resting blood pressure, resting heart rate (HR), resting HR variability (HRV), recovery HR, physical function outcomes, self-reported physical activity level, health-related quality of life and fatigue. Data will be obtained at baseline (t0), after the end of anthracycline-treatment (t2), and three months after t2 (t3). Additionally, N-terminal pro-brain natriuretic peptide levels will be measured 1-24 hours prior to each anthracycline-treatment cycle (t1).
Discussion: The implementation of the present study design, using novel clinical biomarkers, will determine the effect of structured exercise interventions at mitigating ARC, with the overall aim of finding means to further improve BC care.

Trial registration: ISRCTN, ISRCTN32617901. Registered on 24 October 2018. Last updated on 11 January 2019, https://doi.org/10.1186/ISRCTN32617901.
Interprofessional education challenges in medical education of Iran
Authors: Ahmady Soleiman , Mirmoghtadaie Zohrehsadat , Rasouli Davood 
Published: May 2019

Abstract
Background

Interprofessional education is one of the most important educational methods for developing team work encounter with many challenges, especially in developing countries. The purpose of this study was to identify the important challenges of Interprofessional education in Iran's medical educational system.

Methodology

The qualitative content analysis was used to explain the perception and experience of 15 professors and experts regarding the challenges of Interprofessional education with semi structured interviews. The interviews were analyzed with Graneheim and Lundman qualitative approach in the MAXQDA software V.12 interviews were completed.

Findings

According to the participants, the important challenges to designing and implementation of Interprofessional education was: 1) educational challenges, 2) structural challenges and 3) cultural challenges.

Conclusion

Because of the importance of Interprofessional education to enhancing medical education, policymakers need to understand the importance of IPE and address the barriers and challenges they face. Also the Structures must be created and attitudes change.
Identification of large-scale genomic rearrangements during wheat evolution and the underlying mechanisms
Authors: Bariah Inbar , Keidar-Friedman Danielle , Kashkush Khalil 
Published: May 2019

Abstract
Background: Following allopolyploidization, nascent polyploid wheat species react with massive genomic rearrangements, including deletion of transposable element-containing sequences. While such massive rearrangements are considered to be a prominent process in wheat genome evolution and speciation, their structure, extent, and underlying mechanisms remain poorly understood.
Results: In this study, we retrieved ~3500 insertions of a specific variant of Fatima, one of the most dynamic gypsy long-terminal repeat retrotransposons in wheat from the recently available high-quality genome drafts of Triticum aestivum (bread wheat) and Triticum turgidum ssp. dicoccoides or wild emmer, the allotetraploid mother of all modern wheats. The dynamic nature of Fatima facilitated the identification of large (i.e., up to ~ 1 million bases) Fatima-containing insertions/deletions (indels) upon comparison of bread wheat and wild emmer genomes. We characterized 11 such indels using computer-assisted analysis followed by PCR validation, and found that they occurred via unequal intra-strand recombination or double-strand break (DSB) events. In most cases, indels breakpoints were located within transposable element sequences. Additionally, we observed one case of introgression of novel DNA fragments from an unknown source into the wheat genome.
Conclusions: Our data thus indicate that massive large-scale DNA rearrangements might play a prominent role in wheat speciation.
Transverse Versus Longitudinal Uterine Incision in Abdominal Myomectomy: A Randomized Controlled Trial
Authors: Elguindy Alaa , Hemeda Hosam , Shawky Mohamed Esmat , Nawara Maii , Elsenity Mohamed , Elsayed Medhat Adel , Fahim Ahmed , Afifi Khaled 
Published: May 2019

Abstract
Background

It has long been believed that longitudinal uterine incision causes less blood loss than transverse incision in myomectomy, yet knowledge of detailed anatomy of vascular supply of a myoma suggests that transverse incision would be a safe choice. Our aim was to compare between transverse and longitudinal uterine incisions in myomectomy.

Methods

A randomized controlled study in a university affiliated hospital, in which 52 women candidates for abdominal myomectomy were randomized into transverse uterine incision or longitudinal uterine incision groups. Intraoperative blood loss, operative time and postoperative fever were analyzed.

Results

No statistically significant difference was found between transverse and longitudinal incisions regarding intraoperative blood loss (389.7 ± 98.56 ml vs 485.04 ± 230.6 ml respectively, p value=0.07), operative time (59.96 ± 16.78 min vs 66.58 ± 17.33 min respectively, p value=0.18), and postoperative fever (4% vs 8.33%, p value=0.6).

Conclusion

Transverse uterine incision does not cause more blood loss than longitudinal incision and is a reasonable option during abdominal myomectomy.
Trial registration

NCT03009812 at clinicaltrials.gov, registered January 2017
Yustalgie: Remembrance and Material Culture of Socialism as a Frame of Reference for the Consumption of the Present
Authors: Mijić Emilija 
Published: May 2019

The paper is a result of research on consumption processes and nostalgic narratives connected to former Yugoslavia. It deals with the relations between consumption yustalgia and yustalgic consumption, two processes interrogated in nostalgic narratives.
The goal of the research was to explain how people use active memories and nostalgic narratives as a tool of critique for the present socio-political and economical position. In this transitional moment, socialist material culture is a one kind of critique process in post-socialistic discourse.
Developing Foreign Language Presentation Competence of Linguistic Majors through Cooperative Learning
Authors: Dashkina A. I. , Zlobina O. N. 
Published: May 2019

It is essential for linguistic majors to acquire the foreign language presentation competence. This competence includes a complete set of knowledge, aptitudes and skills, as well as psychological characteristics one needs to make a public speech. The experiment described in the article was aimed at ascertaining whether this competence can be formed more efficiently through cooperative learning. In order to assess the extent to which the foreign language presentation competence has been developed, the authors considered the following criteria: foreign language proficiency, knowledge of the subject matter, the ability to structure the presentation and to make slides, and a carefully prepared report. When the report was assessed, the following criteria were taken into account: speech rate and volume, eye contact, pronunciation, vocal fillers, enthusiasm, whether or not mistakes were made and whether the delivery was polished. Such personality traits as self-confidence, intensity, determination, adequate self-evaluation, general knowledge, empathy and willingness to develop oneself are also the inherent components of the foreign language presentation competence. An experiment was conducted to find out whether presentations should be prepared in the process of cooperative learning or individually. In the experimental groups presentations were prepared cooperatively, and the students with a high level of foreign language proficiency helped the ones whose knowledge was rudimentary. In the monitoring groups the students worked individually. Four presentations were made and the students’ progress by the end of the experiment was assessed on the basis of the criteria applied to a public report. In the experimental groups, the students made more progress than those in the monitoring groups. The experiment clearly demonstrates that linguistic majors develop the foreign language presentation competence through cooperative learning.
The Inducing Role and Molecular Basis of Bursal Hexapeptide (BHP) on Avian Immature B Cell
Authors: Feng Xiu Li , Zheng Yang , Hao Shan Shan , Zhou Guang Fang , Chen Pu Yan 
Published: May 2019

Background:The Bursa of Fabricius is an acknowledged central humoral immune organ unique to birds, which provides an ideal research model on the immature B cell development.Objective:In this article, our motivation is to study the role on sIgM and establish the molecular basis and functional processes of Bursal Hexapeptide (BHP) in avian immature B cells DT40 cell lines.Methods:In this article, we detected the expressions of sIgM mRNA with qPCR in DT40 cells with BHP treatment, and investigated the gene expression profiles of BHP-treated DT40 cells, employing microarray analyses. Also, to validate the differentially expressed genes, we performed KEGG pathway and Gene Ontology analysis in the BHP-treated DT40 cells. Finally, we comparatively analyzed the similar regulated genes and their involved immune functional processes between DT40 cell and mouse immature B cell line WEHI231 cell with BHP treatment.Results:Following the proposed framework, we proved that the BHP enhanced the mRNA expression levels of IgM in DT40 cells, and induced 460 upregulated genes and 460 downregulated genes in BHP-treated DT40 cells. The pathway analysis showed that the differentially regulated genes in DT40 cell line with BHP treatment were involved in 12 enrichment pathways, in which Toll-like receptor signaling pathway was the vital pathways, and cytokine-cytokine receptor interaction and Jak-STAT signaling pathway were another two important pathways in BHP-treated DT40 cells. Moreover, BHP induced the immune related biological processes in BHP-treated DT40 cells, including T cell related, cytokine related, lymphocyte related, and innate immune response GO terms. Finally, the comparatively analysis showed that there were two downregulated genes GATA3 and IFNG to be found co-existed among the differentially expressed genes in BHP-treated DT40 cell and WEHI231 cells, which shared some same immune related functional processes in both cell lines.Conclusion:After the applying the framework, we proved the inducing roles and the gene expression profiles of BHP on avian immature B cells, and verified some molecular basis from the KEGG and GO analysis. These results provided the insight for mechanism on immature B cell differentiation, and offer the essential direction for the vaccine improvement.
Suicide Prevention Mobile Apps: Descriptive Analysis of Apps from the Most Popular Virtual Stores
Authors: Castillo-Sánchez Gema , Camargo-Henríquez Ismael , Muñoz-Sánchez Juan Luis , Franco-Martín Manuel , de la Torre-Díez Isabel 
Published: May 2019

Background
Provision of follow-up and care during treatment of people with suicidal intentions is a challenge for health professionals and experts in information and communications technology (ICT). Therefore, health professionals and ICT experts are making efforts to carry out these activities in collaboration by using mobile apps as a technological resource.

Objective
This study aimed to descriptively analyze mobile apps aimed at suicide prevention and to determine relevant factors in their design and development. In addition, it sought to analyze their impact on the support of treatment for patients at risk for suicide.

Methods
We considered 20 apps previously listed in the article “Mobile Apps for Suicide Prevention: Review of Virtual Stores and Literature” (de la Torre et al, JMIR mHealth uHealth 2017;5[10]:e130). To find the apps in this list, the most popular app stores (Android and iOS) were searched using the keyword “suicide prevention.” The research focused on publicly available app information: language, platform, and user ratings. The results obtained were statistically evaluated using 16 parameters that establish various factors that may affect the choice of the user, and the consequent support that the app can offer to a person at risk for suicide.

Results
Of the 20 mobile apps, 4 no longer appeared in the app stores and were therefore excluded. Analysis of the remaining 16 apps sampled showed the following: (1) a high percentage of the apps analyzed in the study (n=13, 82%) are provided in English language; (2) the sampled apps were last updated in 2017, when only 45% of them were updated, but the constant and progressive update of treatments should be reflected in the apps; and (3) the technical quality of these apps cannot be determined on the basis of the distribution of scores, because their popularity indices can be subjective (according to the users). User preference for a particular operating system would require further, more specific research, including study of the differences in the technical and usability aspects between both platforms and the design of medical apps.

Conclusions
Although there are positive approaches to the use of apps for suicide prevention and follow-up, the technical and human aspects are yet to be explored and defined. For example, the design and development of apps that support suicide prevention should be strongly supported by health personnel to humanize these apps, so that the effectiveness of the treatments supported by them can be improved.
IMPLEMENTASI AKUNTANSI DAN MANAJEMEN BAGI PENGUSAHA RENGGINING DESA KOLEANG, KECAMATAN JASINGA, BOGOR
Authors: Wulan Mulyaning , Al Azizah Ummu Salma 
Published: May 2019

ABSTRAK

Desa Koleang terletak di Kecamatan jasinga, Jawa Barat. Dengan jumlah penduduk kurang lebih sebanyak 5000 penduduk, Koleang menjadi kampung yang berpenduduk paling banyak penduduknya dibanding kampung lain di sekitarnya seperti Karundang, Cicanggong, Silongong, Sampalan Kadu, Cisarua dan kampung lainnya. pembuat makanan trdisional yaitu Renggining dan Dapros makanan berbentuk camilan ini merupakan salah satu penggerak perekonomian bagi sebagian besar masyarakat Koleang. Tetapi, sangat di sayangkan kurangnya pemahaman warga tentang pentingnya manajemen keuangan yang baik membuat usaha yang sudah mereka jadikan mata pencaharian selama bertahun-tahun ini sulit untuk berkembang. Tim PKM dari Universitas Muhammadiyah Prof, DR Hamka, merupan dosen yang memiliki dedikasi untuk melaksanakan Catur Darma Perguruan Tinggi. Diharapkan melalui pelatihan yang diadakan dapat menambah kemampuan akuntansi melalui pelatihan pembuatan laporan keuangan. Selain itu, pengusaha renggining diharapkan memiliki kemampuan untuk memanage usahanya terutama dalam inovasi dan pemasaran.

Kata kunci: Usaha Mikro, Pemasaran berbasis internet, Manajemen Usaha, Pengabdian Kepada Masyarakat (PKM)
El emprendimiento como campo de estudio en las instituciones de educación superior: una aproximación desde los postulados de Morin y Habermas
Authors: Moreno Mahecha Yancira 
Published: May 2019

El presente artículo aborda al emprendimiento como campo de estudio, y para ello postula nuevas perspectivas de abordaje: la complejidad y la transdisciplinariedad desde Morin, y los intereses y la acción comunicativa desde Habermas. En este horizonte, plantea por qué el emprendimiento no debe ser pensado solo desde su orientación hacia el empresarismo, sino desde una visión en conjunto que reconozca la responsabilidad social, ambiental y humanística que su ejercicio conlleva. Comprender al emprendimiento como campo de estudio busca favorecer el análisis de una problemática actual observada en la gestión de la formación en emprendimiento en las instituciones de educación superior. Se evidencia un vacío en su concepción sistémica, de ahí que se planteen varias dimensiones de análisis tanto del concepto en sí mismo como de sus implicaciones para el modelo de formación y de gestión en emprendimiento en las universidades colombianas.
Scientists and Theologians in Front of the Mystery
Authors: Magnin Thierry 
Published: May 2019

SCIENCE AND THEOLOGY have their own distinct languages and modes of representing reality. These must be clearly distinguished in order to avoid na¨ıve concordism. However, it is interesting to explore how the methods and logic used in one field can be applicable to the other, taking into account the specific constraints of each. The aim of this paper is to show how the incompleteness of both the scientist and the theologian in their own field is a new way to consider the dialog between science and theology today. We will see that Christian dogmas- Trinity and Incarnation, as well as the biblical notion of Covenant-can, be fruitfully explored through the logic of the “included middle” as applied to quantum physics. This application of methods from one field to another emphasizes that deep, common human attitudes enable both physicists and believers to explore the nature of reality without any confusion between the fields of science and theology. Common attitudes derive from the study of the logic of the included middle and its role in science and theology. Such a field of pursuit is called “moral philosophy” because it is related to critical analysis of the ethical principles involved in comparative epistemologies in science and theology. Taking into account the different domains of science, metaphysics, and theology, we will show how moral philosophy can be a new foundation for the dialog between scientists and people of faith. Such a dialog can perhaps be helpful in promoting quality in education and in supporting peace in the modern world
SOCIAL CLASS IN BRITISH SOCIETY IN JANE AUSTEN’S PRIDE AND PREJUDICE
Authors: Putri Mira Andrea , Bahri Syamsul , Suswati Rita 
Published: May 2019

This study deals with social class in British society in Jane Austen’s Pride and Prejudice. The objectives of this study were to find out the impacts of social class toward british society based on the novel Pride and Prejudice written by Jane Austen and to describe social class reflected toward british society in that novel. The study was conducted by using descriptive qualitative method. The data of this research were dialogues and narration in Pride and Prejudice novel. The analysis of this study was based on Marxist’s concept (1995:25). The findings of this study were (1) two impacts of social class toward british society found in Pride and Prejudice novel, they were pride and prejudice (2) three types of social classes which were reflected, such as power, wealth, and status.
TRANSLATION TECHNIQUES IN MEDAN AND DELI SERDANG TOURISM BOOKLET
Authors: Sasmita Misdahlia , Siregar Masitowarni , Harahap Neni Afrida Sari 
Published: May 2019

This study aims to find out the translation techniques, the dominant one used by the translator in translating the booklets and the process of translating the dominant technique. It uses the theory of Molina and Albir, which are adaptation, amplication, borrowing, calque, compensation, description, discursive creation, established equivalent, generalization, linguistic amplication, linguistic compression, literal translation, modulation, particularization, reduction, substitution, transposition, and variation. In analyzing the data, the research was conducting by using mixed method research which involved collecting both quantitative and qualitative data. The data were taken from “Medan and Deli Serdang Tourism Booklet” which consist of Bahasa and translate into English. In Medan Tourism Booklet the result of literal translation 136 sentences (81,43%) belongs to dominant technique that applied in the booklet, followed by transposition 13 sentences (7,78%), adaptation 8 sentences (4,80%), borrowing 3 sentences (1,80%), amplification 2 sentences (1,20%), description 2 sentences (1,20%), reduction 2 sentences (1,20%) and generalization 1 sentence (0,60%). In Deli Serdang Tourism Booklet the result of literal translation 61 sentences (79,22%) belongs to dominant technique that applied in the booklet, followed by transposition 7 sentences (9,09%), reduction 3 sentences (3,89%), discursive creation 2 sentences (2,60%), particularization 2 sentences (2,60%), adaptation 1 sentence (1,30%) and borrowing 1 sentence (1,30%). There are three process in translating the dominant technique 1) analysis, 2) transfer and 3) restructuring. Keywords: Translation Techniques, Tourism, Booklet