bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative transcriptome analysis revealed the cooperative regulation of sucrose and IAA on adventitious root formation in lotus (Nelumbo nucifera Gaertn)
Authors: libao Cheng , Minrong Zhao , Huiying Liu , Shuyan Li , Zhubing Hu 
Published: July 2019

Abstract
Background

In China, lotus is an important cultivated crop with multiple applications in ornaments, food, and environmental purification. Adventitious roots (ARs), a secondary root is necessary for the uptake of nutrition and water as the lotus principle root is underdeveloped. To investigate the regulatory pathway during ARs formation, we analyzed the expression of genes and miRNAs upon treatment with differential concentrations of sucrose, and a crosstalk between sucrose and IAA was also identified.

Results

We observed that the lotus ARs formation was significantly affected by sucrose treatment. Notably, 20 mg/L sucrose promoted the ARs development, whereas 60 mg/L sucrose inhibited the formation of ARs. The expression of genes and miRNAs was evaluated by high-throughput tag-sequencing. We observed that the expression of 5438, 5184, and 5345 genes was enhanced in the GL20/CK0, GL60/CK0, and CK1/CK0 libraries, respectively. Further, the expression of 73, 78, and 71 miRNAs was upregulated in the ZT20/MCK0, ZT60/MCK0, and MCK1/MCK0 libraries, respectively. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that most of the differentially expressed genes and miRNAs in the GL20/GL60 and ZT20/ZT60 libraries were involved in signal transduction. A large number of these genes (29) and miRNAs (53) were associated with plant hormone metabolism. We observed an association between five miRNAs (miR160, miR156a-5p, miR397-5p_1, miR396a and miR167d) and nine genes (auxin response factor, protein brassinosteroid insensitive 1, laccase, and peroxidase 27) in the ZT20/ ZT60 libraries during ARs formation. Quantitative polymerase chain reaction (qPCR) was used to validate the high-throughput tag-sequencing data.

Conclusions

We found that the expression of many critical genes involved in IAA synthesis and IAA transport was changed after treatment with various concentration of sucrose. Based on the change of these genes expression, IAA and sucrose content, we concluded that sucrose and IAA cooperatively regulated ARs formation. Sucrose affected ARs formation by improving IAA content at induction stage, and increased sucrose content might be also required for ARs development according to the changes tendency after application of exogenous IAA.
Perceptions of emergency medicine and acute care among a cohort of non-emergency medicine health providers in Myanmar
Authors: Bills Corey B. , Acker Peter , McGovern Tina , Walker Rebecca , Ohn Htoo , Mahadevan Swaminatha V 
Published: July 2019

Abstract
Background

Currently, Myanmar does not have a nationalized emergency care or emergency medical services (EMS) system. The provision of emergency medicine (EM) education to physicians without such training is essential to address this unmet need for high quality emergency care. We queried a group of healthcare providers in Myanmar about their experience, understanding and perceptions regarding the current and future needs for EM training in their country.

Methods

A 34-question survey was administered to a convenience sample of healthcare workers from two primary metropolitan areas in Myanmar to assess exposure to and understanding of emergency and pre-hospital care in the country.

Results

236 of 290 (81% response rate) individuals attending one of two full-day symposia on emergency medicine completed the survey. The majority of respondents were female (n=138, 59%), physicians (n=171, 74%), and working in private practice (n=148, 64%). A majority of respondents (n=133, 57%) spent some to all of their clinical time providing acute and emergency care however 83.5% (n=192) of all surveyed reported little or no past training in emergency care; and those who have received prior emergency medicine training were more likely to care for emergencies (>2 weeks training; p=.052). 81% (n= 184) thought the development of emergency and acute care services should be a public health priority.

Conclusions

Although this subset of surveyed health practitioners commonly provides acute care, providers in Myanmar may not have adequate training in emergency medicine. Continued efforts to train Myanmar’s existing healthcare workforce in emergency and acute care should be emphasized.
Effects of risperidone on glucose lipid metabolism and bodyweight in drug-naïve first episode Chinese Han patients with schizophrenia: A prospective study
Authors: Chen Ke , Zhang Xiang Yang , Feng Wei , Lu Yin , Xiu Mei Hong , Chen Da Chun 
Published: July 2019

Abstract
Background: Atypical antipsychotics may have a stronger potential effect on metabolic syndrome. A number of researchs have shown that risperidone have a risk for newly diagnosed hyperglycemia,new-onset diabetes and weight gain. Our study focused on the Chinese han population and used a large sample to study the effects of risperidone on glucose and lipid metabolism in drug-naïve first episode patients with schizophrenia.
Methods: 175 inpatients meeting DSM-IV schizophrenia criteria recruited, 125 patients completed the study. All participants were hospitalized throughout the trial and had to eat the same diets. And patients need to make sure that no antipsychotic drugs other than risperidone or antidepressants are used.The course of risperidone treatment was 4mg-6mg/ day for 10 weeks. They received baseline evaluations before and 10 weeks after risperidone treatment.Patients received total cholesterol,HDL,LDL, triglyceride, plasma glucose, serum insulin levels, HOMA-IR and anthropometric measurements.
Results: The average age of our study was 28.6±9.8 years; the mean course of the disease was 20.9±19.1 months , 14 cases of smoking. After 10 weeks, there were significant increases in BMI, body weight,waist circumference and waist-hip compared with baseline(all P<0.05).The insulin and HOMA-IR levels reached statistical significance compared with baseline(all P<0.05).However, no significant increase in the proportion of patients with IGT and IFG compared with baseline (P= 0.78, 0.72 respectively). Finally, there was a statistically significant increase in cholesterol and triglyceride levels (P = 0.05, 0.00 respectively). After 10 weeks of risperidone treatment, male patients had higher body weight, waist-to-hip ratio and waist circumference than female patients (all p <0.01).
Conclusion:Risperidone increased insulin, total cholesterol, triglycerides, body weight, BMI, homa-ir level, waist-hip ratio, and waist circumference in patients with schizophrenia.There were significant gender differences in waist-to-hip ratio,weight gain , and waist circumference among patients treated with risperidone
SURVIVAL AND TREATMENT OUTCOMES OF PEDIATRIC SOFT TISSUE AND BONE SARCOMAS IN TANZANIA
Authors: Abraham Zephania Saitabau , Mithe Siwillis Elizabeth , Dharsee Nazima , Scanlan Trish , Ngoma Mamsau , Kahiu Josephine , Million Lynn 
Published: July 2019

Abstract
Background

Pediatric sarcomas represent an important group of childhood tumors who require treatment at Muhimbili National Hospital (MNH), the largest pediatric oncology center in Tanzania. Treatment is often adapted from established childhood protocols validated in clinical trials from the United States and United Kingdom. There are no studies describing the outcomes of treatment in Tanzania to understand similarities and disparities with other countries. The objective of this study was to describe the treatment outcomes including the overall survival for children seen at MNH.

Methods

Data on treatment outcome was collected on all children seen at MNH pediatric oncology unit between 2011 and 2016 with a confirmed histological diagnosis of either bone or soft tissue sarcoma.

Results

A total of 135 cases were analyzed; 89 (66%) were Soft tissue sarcoma (STS) and 46 (34%) were bone sarcomas. In the STS group, 37 (41.6%) achieved a complete response, 12 (13.5%) achieved a partial response and 40 (44.9%) had no response. Factors found to be significantly associated with a higher complete response rate included early stage disease (stage I or II), embryonal histology, tumor in favorable sites and tumor size of <5cm for STS and <8cm for the bone sarcomas. There was a trend for better 2-year overall survival for STS in early stage disease (74.5%) compared to late stage disease (20.6%), p<0.001. A similar trend was noted for the bone sarcomas; 91.7% versus 25.3% for early stage and late stage disease respectively, p=0.001.

Conclusions

This report is the first study documenting the treatment outcome for pediatric sarcomas seen in Tanzania. Disease stage is strongly related to treatment outcome with later stages of the disease having an overall poor prognosis.
Calculator and Prediction Score for Early-onset Neonatal Sepsis in Asymptomatic Term Infant: A Determinant Model
Authors: Hendrarto Toto Wisnu , Hadinegoro Sri Rezeki , Karuniawati Anis , Sukadi Abdurachman , Kesson Alison 
Published: July 2019

Abstract
Background

Risk estimation of early-onset neonatal sepsis (EONS) in asymptomatic term infants is sometimes considered less often among clinician. The cumulative case number is large and we aimed to develop a calculator and scoring system as a determinant model of early onset neonatal sepsis (EONS) in asymptomatic term infants with premature rupture of the membranes (PROM) by combining maternal factors and umbilical cord blood examination to guide more targeted antimicrobial therapy.

Method

This is a cross-sectional study involving infants born to mothers with premature rupture of the membranes for > 12 hours who are term and asymptomatic. We investigated the maternal clinical status, maternal blood and urine examination and infant cord blood examination. Independent predictors were identified by using bivariate and multivariable analysis, then developed into a calculator and scoring system with ideal and optimal cut-off.

Result

A total of 334 infants with PROM were involved in this study with 62 diagnosed with EONS. The overall incidence in all term births of culture-proven EONS was 4.6 per 1,000 live births. Independent predictors were vaginal birth (OR 2.39; 95%CI 1.19, 4.80), foul-smelling amniotic fluid (OR 1.93; 95%CI 1.01 -3.70), maternal blood WBC > 15,000/mm3 (OR 2.01; 95%CI 1.09-3.73), cord blood WBC > 15,000/mm3 (OR 1.84; 95%CI 1.01-3.39), cord blood C-reactive protein (CRP) > 0.15 mg/L (OR 1.16; 95%CI 1.01-1.33), and cord blood interleukin-6 (IL-6) > 10 ng/L (OR 5.38; 95%CI 2.88-10.04). We developed two models: IndEONS 1 (with IL-6) and IndEONS 2 (without IL-6), both in the form of a calculator and scoring system. All models have good performance with consistent validity. The result was infant stratification into low, medium, or high EONS risk each with a corresponding management recommendation. Only high risk infants should get empirical antibiotics.

Conclusion

A new calculator and scoring system are a useful tool to quantify EONS risk among asymptomatic term infants.
The Impact of the donor-recipient gender matching on the graft survival from live donors
Authors: Naderi Gholamhossein , Azadfar Amin , Yahyazadeh Seyed Reza , Khatami Fatemeh , Aghamir Seyed Mohammad Kazem 
Published: July 2019

Abstract
Background

Several factors are important in order to predict the graft survival in kidney transplant recipients like the age of recipient, BMI, serum cratinine, and having history of dialysis. One factor that can have impact of transplant outcomes but not considered can be the age of donor and recipients.

Patients and Methods

The numbers of 1113 kidney transplant recipients were considered through a retrospective cohort study. Several factors were taken into the account of graft survival and outcomes like gender and age of donor and recipients in addition to common recipient factors like cratinine, eGFR, BMI, and positive history of dialysis.

Results

The most successful transplant based on donor-recipient gender was seen in male donor to male recipient and then male donor to female recipient. In female transplant recipient the level of serum creatinine, and eGFR, have dialysis history before transplant, and low donor hemoglobin level can be a good prognosis factor that should considered for kidney transplant survival.

Conclusions

Our result suggested that the gender match is suggested for kidney transplant. On some exceptional occasion just kidney of male donor to female recipient may be successful and it would be better to hesitate female donors to male recipients especially in aged patients with history of dialysis.
VIVER E MORRER COM DIGNIDADE: BREVES REFLEXÃ•ES SOBRE A EUTANÃSIA E SEU SANCIONAMENTO NO BRASIL
Authors: Lamas LÃ­via Paula de Almeida 
Published: July 2019

A eutanÃ¡sia Ã© um tema muito discutido ao longo dos anos e que sempre provocou opiniÃµes controversas. Este artigo tem por escopo apresentar algumas reflexÃµes sobre o assunto, realizando uma anÃ¡lise frente Ã legislaÃ§Ã£o brasileira. Trata-se de assunto de grande importÃ¢ncia que ainda precisa de discussÃ£o aprofundada por toda a sociedade, para que direitos fundamentais nÃ£o venham a ser desrespeitados.
The effect of recent climate shifts on optimal sowing windows for wheat in Punjab, India
Authors: Sandhu S. S. , Kaur Prabhjyot , Gill K. K. , Vashisth B. B. 
Published: July 2019

AbstractThe productivity of wheat is highly vulnerable to climate change. Optimizing the sowing period of a crop may be one of the most important climate resilient strategies to optimize yield. First, the CERES-Wheat model was used to analyze effects of climate change on the optimum sowing window of wheat. Second, it was used to determine the optimum sowing window for different zones within Punjab state, India. The simulation results suggested that climate change has caused a shift in the optimum sowing window of wheat. The current (2006–2015 weather data) optimum sowing window is 22–28 October in north eastern Punjab, 24–30 October in central Punjab, and 21–27 October in south western Punjab. The rate of decrease in productivity with delay in sowing from the optimum sowing window by each day was lowest for north eastern Punjab (36.09 kg ha−1 day−1) and highest for south western Punjab (70.80 kg ha−1 day−1). The methodology followed in this study can be useful in determining the optimum sowing time of various crops.
Predicting and Preventing Sudden Cardiac Death in the Young
Authors: Maharani Erika 
Published: July 2019

Sudden cardiac death (SCD) is an unexpected death condition and occurs with unknown causes or cardiac condition. The SCD incidence at young age is a rare condition but when this condition happens it become traumatic event for both family and community. Incidence rate of death on 1-35 years old is around 0.8-2.8/100.000 each year. This number also varies according to age and sex. Death incidence on 1-4 years old is more common than on 5-10 years old group. This number is increasing after 15 years old, where age of 31-35 years has 10 fold risk of SCD compared to 1-10 years old group. Ratio of SCD in men and woman are 2: 1. Early detection of underlying heart disease is the most important action of preventio. If young people are known to have a risk of SCD, the lifestyle changing and appropriate medical therapy, including implantation of implantable cardioverter defibrillator, according to risk stratification must be done.
Is Plaque Rupture Always Responsible in Acute Coronary Syndrome?
Authors: Gharini Putrika Prastuti Ratna 
Published: July 2019

The majority cause of myocardial infarction is the atherothrombotic event, mainly cause by plaque rupture. Since the 20th century, it was found that the plaque rupture was not the solely condition responsible for the acute coronary syndrome. With the invention of more sensitive myocardial biomarker, a series of guideline was written as guideline for the definition of myocardial infarction. This review discuss about the consensus in the Universal Definition of Myocardial Infarction.
Identidad latinoamericana. Las raíces, la historia, los conceptos
Authors: Acevedo López María Guadalupe 
Published: July 2019

En América Latina hay un rico y complejo esfuerzo de intelectuales que a lo largo de la historia regional se preocupan por reflexionar sobre el "modo de ser" propio de los pueblos que la integran y del conjunto latinoamericano como un todo.
Quiebres epistemológicos para la enseñanza de la teoría cuántica
Authors: Muñoz Burbano Zulman Estela 
Published: July 2019

Este artículo es resultado de la investigación desarrollada dentro del proyecto macro titulado: Enseñanza de la Estructura Atómica de la Materia. La metodología seguida es una adaptación de las metodologías utilizadas en la realización de estados del arte, que se realiza en dos fases: una heurística, o de recopilación de la información, y una fase hermenéutica, que corresponde al análisis de la información y consolidación de la reflexión. El problema planteado es una enseñanza de la Estructura atómica de la materia simplista y de poca profundidad, que no toma como base la Teoría Cuántica.

El documento establece un breve recorrido por la historia de la filosofía y la historia de las ciencias, desde la Grecia Antigua hasta inicios del siglo XX. Parte de la epistemología de Tomas Kuhn, la dinámica de la “ciencia normal” y la disrupción que generan las “revoluciones científicas” y cómo deberían tomarse en cuenta en la enseñanza de la Teoría Cuántica. Dentro de los quiebres epistemológicos que se describen están: el atomismo de Demócrito, el paso del modelo geocéntrico al modelo heliocéntrico y la ruptura en el pensamiento que significa el advenimiento de la Teoría Cuántica, con énfasis en la posibilidad de asumir estas rupturas para la enseñanza de esta teoría. Concluye con la necesidad de una enseñanza que asumiera la historia de las ciencias y la filosofía, con un acento en los quiebres epistemológicos que el paso de un paradigma a otro requiere, especialmente en el quiebre que demanda la Teoría Cuántica y el indeterminismo que le subyace.
THE EFFECT OF BOARD OF DIRECTOR, BOARD OF COMMISSIONER AND AUDIT COMMITTEE ON VALUE OF FIRM TO ISLAMIC SOCIAL REPORTING AS A MEDIATING VARIABLE
Authors: LIDYAH RIKA , AMIR AMRI , YACOB SYAHMARDI , RAHAYU SRI 
Published: July 2019

This research aim to analyze the effect of number of Board of Directors, number of Commissioners and audit committee of the company with the Islamic social reporting as mediation variables. This research was conducted on the basic and chemical industrial enterprises registered in the ISSI. The research found that the number of Board of Director, number of Commissioners and audit committee of the value of firm affects. The number of Board of Director of Islamic have effect on social reporting, whereas number of Commissioner and audit committee do not have effect to the Islamic social reporting. Islamic social reporting can mediate all the variables (the number of Commissioner and the Board of Director, the audit committee of the company)
BUYA HAMKA: KETELADANAN MULTITALENTA TANAH MELAYU NUSANTARA
Authors: Bahar Mahdi , M Hartati 
Published: July 2019

Buya HAMKA adalah tokoh Multi Talenta Nusantara banyak meninggalkan karya tulis, selain sebagai ulama, sastrawan, pendakwah, dan politikus. Sepanjang hayatnya senantiasa memperjuangkan ideologi berbasis ajaran tauhid. Suka dan duka, segudang pengalaman, pahit dan manis dijalani Buya HAMKA. Penghargaan demi pengahragaan diperolehnya, baik nasional maupun internasional. “Kebesaran” Buya HAMKA yang ditunjukkan melalui karya dan aktivitas semasa hidup, diteroka di tanah alam perjuangan mengisi kemerdekaan. Sekalipun perjuangan beresiko masuk penjara, namun akhirnya pemerintah Republik Indonesia menganugerahkan gelar Pahlawan Nasional kepada Buya HAMKA. Ketokohan Buya HAMKA merupakah anugerah yang patut ditauladani oleh para generasi di persada Nusantara.
NILAI-NILAI YANG TERKANDUNG DALAM TRADISI LISAN BIDUK SAYAK MASYARAKAT DESA JERNIH
Authors: Suryani Irma , Rahariyoso Dwi , Maulana Rio Yudha 
Published: July 2019

Tujuan penelitian ini mendeskripsikan nilai-nilai yang terkandung dalam tradisi lisan Biduk Sayak masyarakat desa Jernih. Penelitian ini dilakukan di Desa Jernih Kecamatan Air Hitam Kabupaten Sarolangun Provinsi Jambi.
Unsur-unsur yang terkandung dalam tradisi lisan biduk sayak, terdiri atas seniman tradisi lisan biduk sayak, alat musik, waktu dan tempat pertunjukan, kostum pemain, penonton, dan lagu yang disajikan dalam pementasan tradisi lisan biduk sayak. Keunikan tradisi lisan biduk sayak antara lain, Senimannya terdiri atas: pemain biola dengan senar tiga, pemain kicer/kecir, penggendang ketipung, penggendang celiti, dan vokalis atau penyanyi. Keunikan selanjutnya yaitu, Lirik lagu bentuk seperti pantun dan satu baid dengan baid lainnya saling terkait. Lirik-lirik suatu lagu pada suatu acara misalnya pernikahan, bisa saja digunakan untuk acara turun mandi, yang penting maknanya sampai dan cocok. Nilai-nilai yang terkandung dalam tradisi lisan biduk sayak yaitu nilai budaya, moral, dan religius. Nilai budaya yang ditemukan yaitu ketakwaan, bersyukur, kerukunan, kasih sayang, harapan, pengorbanan, keikhlasan, kesopanan, dan memberi nasihat, Selanjutnya nilai moral yang ditemukan dalam tradisi lisan biduk sayak yaitu tolong menolong dan saling menghargai. Nilai religius yang ditemukan ialah akhlak, keikhlasan, dan kedisiplinan.
Recycle Limbah Plastik Jenis PET (Polyethylene Terepthalate) dengan Proses Pirolisis dengan katalis Silika-Alumina
Authors: Salamah Siti , Maryudi Maryudi 
Published: July 2019

Limbah/ Sampah plastik di dunia semakin meningkat setiap tahunnya, bahkan hingga menyentuh angka yang sangat mengkhawatirkan. Sampah yang paling banyak ditemukan adalah jenis PET. Selain itu ketahanan energi saat ini perlu diperhatikan juga, sehingga teknologi dalam mengkonversi sampah menjadi energi dengan proses pirolisis penting dilakukan. Penelitian ini dilakukan dengan menggunakan bahan baku sampah PET berupa botol bekas yang berasal dari sekitar dengan katalis berupa katalis SiO2/Al2O3 berbentuk butiran. Penelitian dilakukan dengan reaktor fixed bed berbahan stainlees steel yang dilengkapi dengan condensor. Penelitian dilakukan dengan pengecilan ukuran plastik PET (1-2 cm) dan proses pirolisis dilakukan pada suhu 450 oC pada waktu 2 jam dengan variabel berat katalis tetap yaitu 4,8,12 dan 16 gram. Produk pirolisis dianalisis dengan FTIR (F… tranfor Infra Red) dan Gas Kromatografi MS-Pac. Dari penelitian ini dihasilkan produk pirolisis berujud gas dan cairan yang dalam yang temperatur ruangan berujud padatan berwarna kuning, dengan titik lebur 90 0 C. Pirolisis optimal terdapat pada suhu 450 OC dengan katalis 1 % berat umpan 400 gr diperoleh yield 14 %. Hasil analaisi FTIR (Fourier Transform Infrared Spectroscopy) menunjukkan dalam produk mengandung gugus benzene, gugus karbonil, gugus ester, gugus hidroksil. Kandungan senyawa yang paling dominan pada hasil analisis GC-MS adalah asam benzoate 71 %, yang merupakan monomer dari PET dan senyawa turunan asam benzoate ( toluene dan isomernya ) 15 %,Biphenil 4 % dan triphenil 7 %