bluuebunny/crossref_metadata_2025_split huggingface dataset:
Put at and kept from risk: The sexual risk dilemmas confronting marginalized youth
Authors: Bay‐Cheng Laina Y. , Sutton Emily R. ,   4tRecord Research Team
Published: November 2024

AbstractIntroductionThe current study examines Bay‐Cheng and Ginn's (2024) claim that marginalized youth confront two intertwined sexual risk dilemmas: being put at risk by unjust social forces and structures that threaten their sexual health and safety; and being kept from risk by those same forces and structures, thus compromising their development and dignity.MethodsWe explored the presence and relevance of these dilemmas using interviews conducted in 2022 with 101 racialized and/or queer (i.e., a sexuality other than exclusively heterosexual) young women and trans or nonbinary youth aged 16–21 and living in Melbourne (Australia), New York City (United States), and Toronto (Canada). We conducted a directed content analysis of the data and examined intersectional group‐based comparisons of code frequencies.ResultsWe found that 80% of participants felt endangered (i.e., put at risk) and/or obstructed (i.e., kept from risk) by social and material conditions. Over half felt put at risk through exposure to hostility and harm, and over one‐third of participants described precarious life circumstances as keeping them from taking wanted sexual risks. Group‐based and intersectional comparisons indicated that feeling put at risk is associated with marginalized gender and sexuality identities and corresponding discrimination. We also found tentative signs that feeling kept from risk may be more closely linked to race and racism than marginalization by gender and/or sexuality.ConclusionsThe findings highlight the diverse implications of interlocked social injustices for youths' sexual lives, particularly the infringement on their rights both to safety and to risk.
Adolescents' meaning making of salient emotional experiences during the COVID‐19 pandemic
Authors: Peplak Joanna , Taffe Rachel , Klemfuss J. Zoe 
Published: November 2024

AbstractIntroductionThis mixed‐method longitudinal study examined American adolescents' meaning making of salient COVID‐19 pandemic events.MethodWithin phone interviews, adolescents (N = 124, Mage = 15.76 years; 46% Latine) narrated their most emotionally impactful pandemic experience at two time points ~30 days apart between July 2020 and March 2021. Narratives were coded for (1) content (i.e., event‐type, relation to the pandemic, and the valence of the event [positive or negative]), (2) linguistic markers of subjective event processing (internal state language such as positive emotion, negative emotion, and cognition words), (3) narrative meaning‐making, and (4) the outcome of adolescents' meaning‐making (i.e., their “meanings made”).ResultsAbout 30% of adolescents spontaneously made meaning of their experience. Negative emotion words within narratives at time 1 positively predicted meaning making at time 2. Meaning making at time 1 predicted increased use of cognition words at time 2. Meaning making themes included: recognizing the threat of COVID‐19, coping with a pandemic, and shifts in perspectives.DiscussionSalient emotional experiences that occur during adolescence are likely to be remembered and contribute to one's life story. This work provides a window into how the COVID‐19 pandemic may have shaped adolescent development in the United States.
The Effects and Mechanisms of Chrysosplenetin in Targeting RANKL‐Induced NF‐κB Signaling and NFATc1 Activation to Protect Bone Density in Osteolytic Diseases
Authors: Hong Guoju , Zhou Lin , He Wei , Wei Qiushi , Xu Jiake 
Published: November 2024

ABSTRACTChrysosplenetin (CHR), an O‐methylated flavonol from Chamomilla recutita and Laggera pterodonta, has previously demonstrated efficacy in enhancing osteoblast differentiation for treating postmenopausal osteoporosis. This study aims to evaluate CHR's potential to inhibit osteoclastogenesis and prevent bone deterioration in both in vitro and in vivo models. Using tartaric acid‐resistant acid phosphatase staining and hydroxyapatite resorption assays, we examined the impact of CHR on RANKL‐induced osteoclasts derived from mouse bone marrow monocytes. Additionally, Western blot analysis and qRT‐PCR were utilized to assess the protein and gene expressions within the MAPK and NF‐κB signaling pathways, as well as the NFATc1 pathway. In vivo, CHR's effects were validated using micro‐CT and histomorphometry in an ovariectomized mouse model, showing significant reduction in osteoclast activity and bone loss. The study confirms CHR's inhibition of osteoclastogenesis through interference with RANKL‐mediated signaling pathways, suggesting its potential as a novel therapeutic agent for osteolytic conditions related to osteoclast‐osteoblast dysregulation.
Fear of reinjury after acute Achilles tendon rupture is related to poorer recovery and lower physical activity postinjury
Authors: Larsson Elin , LeGreves Agnes , Brorsson Annelie , Eliasson Pernilla , Johansson Christer , Carmont Michael R. , Nilsson Helander Katarina 
Published: November 2024

AbstractPurposeThe aim of this study was to investigate how fear of reinjury to the Achilles tendon affects return to previous levels of physical activity and self‐reported Achilles tendon Total Rupture Score (ATRS) outcomes.MethodsData were collected from a large cohort of patients treated for an acute Achilles tendon rupture at Sahlgrenska University Hospital Mölndal between 2015 and 2020. The ATRS and additional questions concerning fear of reinjury, treatment modality, satisfaction of treatment and recovery were analyzed 1–6 years postinjury. Analysis was performed to determine the impact of fear of reinjury on patient‐reported recovery and physical activity.ResultsOf a total of 856 eligible patients, 550 (64%) answered the self‐reported questionnaire and participated in the follow‐up. Of the participants, 425 (77%) were men and 125 (23%) were women. ATRS, recovery in percentage, satisfaction of treatment, recovery on a 5‐point scale and physical activity level post‐ versus preinjury were significantly related to fear of reinjury (p < 0.001). Of the nonsurgically treated patients, 59% reported fear of reinjury compared to 48% of the surgically treated patients (p = 0.024) Patients that reported fear of reinjury had a 15‐point lower median ATRS score than those who did not (p < 0.001).ConclusionMore than half of patients who have suffered an Achilles tendon rupture are afraid of reinjuring their tendon. Patients who reported fear of reinjury exhibited a significantly lower ATRS score. This indicates the importance of addressing psychological aspects in the treatment after this injury.Level of EvidenceLevel II.
Genetic testing and counseling for hypertrophic cardiomyopathy: An evidence‐based practice resource of the National Society of Genetic Counselors
Authors: Miller Erin M. , Brown Emily , Christian Susan , Kelly Melissa A. , Knight Linda M. , Saberi Sara , Rigelsky Christina , Ingles Jodie 
Published: November 2024

AbstractHypertrophic cardiomyopathy (HCM) is a common hereditary condition affecting approximately 1 in 500 adults. It is characterized by marked clinical heterogeneity with individuals experiencing minimal to no symptoms, while others may have more severe outcomes including heart failure and sudden cardiac death. Genetic testing for HCM is increasingly available due to advances in DNA sequencing technologies and reduced costs. While a diagnosis of HCM is a well‐supported indication for genetic testing and genetic counseling, incorporation of genetic services into the clinical setting is often limited outside of expert centers. As genetic counseling and testing have become more accessible and convenient, optimal integration of genomic data into the clinical care of individuals with HCM should be instituted, including delivery via genetic counseling. Drawing on recommendations from recent disease guidelines and systematic evidence reviews, we highlight key recommendations for HCM genetic testing and counseling. This practice resource provides a comprehensive framework to guide healthcare providers in the process of genetic test selection, variant classification, and cascade testing for genetic evaluation of HCM.
Prognostic role of lipoprotein(a) in atherosclerotic cardiovascular disease risk from a perspective on current risk stratification
Authors: Li Sha , Liu Hui‐Hui , Zhang Yan , Zhang Meng , Zhang Hui‐Wen , Zhu Cheng‐Gang , Wu Na‐Qiong , Xu Rui‐Xia , Dong Qian , Qian Jie , Dou Ke‐Fei , Guo Yuan‐Lin , Li Jian‐Jun 
Published: November 2024

AbstractLipoprotein(a) [Lp(a)] is an emerging predictor for atherosclerotic cardiovascular disease (ASCVD) but the association from a perspective on current risk stratification was unknown. A cohort of 9944 Chinese patients with ASCVD was recruited and refined into very‐high‐risk (VHR) and non‐VHR subgroups according to current guideline. Lp(a) plasma levels were divided by its concentration (<30, 30–50, 50–75, and ≥75 mg/dL) and percentile zones (<25th, 25–50th, 50–75th, 75–90th, ≥90th). Cardiovascular events (CVEs) occurred during an average of 38.5 months’ follow‐up were recorded. We found that Lp(a) was increased with risk stratification of ASCVD increasing. Prevalence of CVEs had a significantly increasing trend with gradients of Lp(a) elevation in VHR but not in non‐VHR subgroup. The adjusted HRs (95%CIs) for CVEs were 1.75(1.25–2.46) in the highest group of Lp(a) ≥75 mg/dL compared with the group of Lp(a) <30 mg/dL as the reference in overall patients, 2.18(1.32–3.58) in VHR subgroup and 1.43(0.93–2.18) in non‐VHR subgroup, respectively. The adjusted HRs (95%CIs) at the highest grade of Lp(a) levels (≥90th) were 1.72(1.19–2.50) in overall population, 2.83(1.53–5.24) in VHR subgroup and 1.38(0.86–2.12) in non‐VHR subgroup, respectively. These findings suggested that Lp(a) might contribute more to CVEs risk in VHR subgroup of ASCVD.
Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk
Authors: Fan Hua‐Yang , Liang Xin‐Hua , Tang Ya‐Ling 
Published: November 2024

AbstractCancer neuroscience is an emerging field that investigates the intricate relationship between the nervous system and cancer, gaining increasing recognition for its importance. The central nervous system governs the development of the nervous system and directly affects brain tumors, and the peripheral nervous system (PNS) shapes the tumor microenvironment (TME) of peripheral tumors. Both systems are crucial in cancer initiation and progression, with recent studies revealing a more intricate role of the PNS within the TME. Tumors not only invade nerves but also persuade them through remodeling to further promote malignancy, creating a bidirectional interaction between nerves and cancers. Notably, immune cells also contribute to this communication, forming a triangular relationship that influences protumor inflammation and the effectiveness of immunotherapy. This review delves into the intricate mechanisms connecting the PNS and tumors, focusing on how various immune cell types influence nerve‒tumor interactions, emphasizing the clinical relevance of nerve‒tumor and nerve‒immune dynamics. By deepening our understanding of the interplay between nerves, cancer, and immune cells, this review has the potential to reshape tumor biology insights, inspire innovative therapies, and improve clinical outcomes for cancer patients.
Simultaneous measurement of carbon monoxide and carbon dioxide for combustion diagnosis using 2 μm laser absorption spectroscopy
Authors: Li Jinyi , Wang Keming , Zhou Yun , Wang Zehua , Ji Yue , Du Zhenhui , Yang Xiaotao 
Published: November 2024

AbstractCarbon monoxide (CO) and carbon dioxide (CO2) are products of incomplete combustion and complete combustion, respectively. Time‐resolved knowledge of CO and CO2 exhaust concentrations will aid in improving combustion strategies, control, and efficiency. To achieve online high‐precision simultaneous measurement of CO and CO2, a tunable diode laser absorption spectroscopy‐based sensor is designed and constructed. Two diode lasers with central wavelengths of 2.3 and 2.0 μm are multiplexed in time‐division to cover the absorption spectral lines of CO at 4285.00 cm−1 and CO2 at 4989.96 cm−1, respectively. Wavelength modulation spectroscopy with second harmonic detection normalized by the first harmonic (WMS‐2f/1f) is employed. A software lock‐in amplifier and inversion algorithm are implemented for data processing and concentration acquisition. The entire measurement system is based on the idea of a virtual instrument and is carried out using a high‐speed data acquisition card and a computer. Experimental verification demonstrates that the measurement accuracies of CO and CO2 were 2.47% and 2.56%, respectively, with a time resolution of 20 ms. Dynamic measurement experiments with an alcohol blast burner validate the feasibility of measuring CO and CO2 in actual combustion environments. The developed sensor demonstrates the potential for real‐time and in situ carbon emission measurement for combustion diagnosis.
Asymmetric Coplanar Strip Loaded With Meander Lines for Multiband Operations Using ANN Optimization
Authors: Priya S. Janu , Daniel R. Samson 
Published: November 2024

ABSTRACTA miniaturized asymmetric coplanar strip fed with meander lines is developed for hexaband wireless applications. Multiband with compact size of the antenna is developed by using meander lines. The designed antenna is enhanced by an increased number of meander lines. The invented antenna is composed of three meander lines, it yields the antenna to excite 1.13, 2.35, 2.91, 3.46, 3.96, and 4.5 GHz, respectively. The prototype antenna is fed by ACS, which is printed on a 14  24  1.6 mm3 FR‐4 substrate and dielectric constant of Ɛr = 4.4. MATLAB tool is utilized in the ANN computation to amend the physical values of the antenna. The calibrated and simulated radiation attributes are identical with each other. The designed antenna provides distinguishing characteristics such as good reflection coefficient, impedance matching, and size miniaturization. It imparts empirical peak gains of 0.028 dBi at 1.14 GHz, 1.305 dBi at 2.35 GHz, 1.54 dBi at 2.86 GHz, 1.79 dBi at 3.43 GHz, 2.43 dBi at 3.96 GHz, and 2.58 dBi at 4.5 GHz, which is suitable for GSM/WLAN/WiMAX and C‐band wireless applications.
The herbicidal activity and mechanism of Talaromyces purpureogenusCY‐1 metabolites
Authors: Yang Chunping , Lu Yuan , Yang Yinhua , Hu Jiayun , Yang Yifen , Zhang Min , Gong Guoshu , Chen Huabao , Jiang Chunxian 
Published: November 2024

AbstractBACKGROUNDStudies have shown that Talaromyces can produce a large number of secondary metabolites in its metabolic process, many of which have good insecticidal, antibacterial, antitumor, antiviral and other biological activities. In order to explore the herbicidal activity and mechanism of Talaromyces purpureogenus CY‐1, we determined the inhibitory effect of the fermentation broth of the CY‐1 strain on weeds, identified the major active components, and further investigated the herbicidal mechanism.RESULTThe results showed that CY‐1, with IC50 values of 5.40 g/L and 4.39 g/L, respectively, exhibited good herbicidal activity against Xanthium sibiricum and Amaranthus lividus. Spraying CY‐1 strain fermentation broth on redroot pigweed resulted in plant protection efficiencies and fresh weight protection efficiencies of 83.7% and 87%, respectively. The active component identified in the broth was 2‐(3‐hydroxybenzoyloxy) acrylic acid. Treatment of Amaranthus lividus with 2‐(3‐hydroxybenzoyloxy) acrylic acid resulted in trends of increasing superoxide dismutase activity, peroxidase activity, respiratory rate, cytochrome oxidase activity, and soluble protein content, followed by a decrease. Peroxidase activity, relative conductance and malondialdehyde content gradually increased, while acetyl lactate synthase and glutamine synthetase initially decreased and gradually returned to normal. The soluble sugar content showed a gradual decrease.CONCLUSIONThe findings of the present study indicate that 2‐(3‐hydroxybenzoyloxy) acrylic acid can induce oxidative stress in plants, damaging plant cell walls, weakening respiratory activity, inhibiting protein synthesis and sugar metabolism, ultimately leading to weed wilting and death. © 2024 Society of Chemical Industry.
Toward economic resilience in Sub‐Saharan Africa: The role of institutional quality and human capital development
Authors: Afolabi Joshua Adeyemi , Raifu Isiaka Akande 
Published: November 2024

AbstractA viable economy's hallmark is its ability to generate positive growth rates and its capacity to sustain such growth, especially during a crisis. Economic crises have the potential to induce uncertainty, reverse pre‐crisis economic gains and force preexisting challenges to reemerge, necessitating actions on building economic resilience. Given the fragility of most countries in Sub‐Saharan Africa (SSA), the current paper evaluates the role of institutional quality (INSQ) and human capital development in boosting economic resilience in SSA. The sampled countries were classified into fragile and resilient countries. Annual data spanning 2000–2021 was obtained and analyzed using the Bias‐Corrected Method of Moments (BCMM) estimation method, which can adequately account for cross‐sectional dependence, endogeneity, and heterogeneity in the sample. The results revealed that human capital development improves the resilience of fragile and non‐fragile economies, and INSQ has a higher positive impact in fragile countries than in non‐fragile countries. The results of the bundled INSQ support the positive effect of economic governance, institutional governance, and political governance on the resilience of fragile and non‐fragile countries. Therefore, group‐specific economic resilient policies need to be designed to strengthen economic resilience in the SSA region, and buffers that will ensure a healthy response to economic crises need to be strengthened. In addition, sound institutions and massive investment in human capital development should be pursued to boost economic resilience in the SSA region.
Association between adenomyosis volume and adverse perinatal outcomes: multicenter cohort study
Authors: Ni X. , Su X. , Shi Y. , Ru P. , Liu Y. , Lei S. , Gu Y. , Liu M. , Duan T. 
Published: November 2024

ABSTRACTObjectiveTo assess the association between adenomyosis volume, as a reflection of its severity, and the risk of adverse perinatal outcomes.MethodsThis multicenter retrospective cohort study was conducted at a comprehensive tertiary care institution and a tertiary maternal and child healthcare hospital, which are the main types of hospital providing maternal medical care in China. The study included pregnant women without adenomyosis (non‐AD cohort) who delivered between 1 January 2021 and 31 December 2021, and women with pregnancy complicated by adenomyosis (AD cohort) who delivered between 1 January 2020 and 31 December 2022. Adenomyosis was diagnosed and measured using transvaginal or transabdominal ultrasound up to 14 weeks of gestation. The adenomyosis volume (V) was calculated based on the sonographic measurement of three dimensions, using the formula V = (length × width × thickness) × 4/3π. Univariate and multivariate logistic regression analyses were conducted to assess the association between adenomyosis and the risk of pregnancy complications. We also performed a sensitivity analysis among 226 pregnancies complicated by adenomyosis that had volume measurements available and 10 507 pregnancies without adenomyosis, using as a threshold for severe adenomyosis the 3rd quartile of adenomyosis volume.ResultsThe study group included 10 507 pregnant women in the non‐AD cohort and 321 in the AD cohort. Pregnancies complicated by adenomyosis had an increased risk of preterm birth < 37 weeks of gestation (adjusted odds ratio (aOR), 2.39 (95% CI, 1.65–3.48)), spontaneous preterm birth < 37 weeks of gestation (aOR, 2.57 (95% CI, 1.54–4.28)), placenta previa (aOR, 2.57 (95% CI, 1.41–4.67)), cervical incompetence (aOR, 9.70 (95% CI, 4.00–23.55)) and abnormal fetal presentation (aOR, 2.04 (95% CI, 1.39–3.00)), and there was also a non‐significant trend toward increased risk of pre‐eclampsia (aOR, 1.64 (95% CI, 0.94–2.85)). Sensitivity analysis revealed there was a greater risk in pregnancies with severe (≥ 757.5 cm3) vs mild adenomyosis of preterm birth < 37 weeks of gestation (aOR, 5.50 (95% CI, 2.80–10.82) vs aOR, 1.73 (95% CI, 0.98–3.05)), pre‐eclampsia (aOR, 4.94 (95% CI, 2.11–11.58) vs aOR, 1.03 (95% CI, 0.41–2.58)), placenta previa (aOR, 6.37 (95% CI, 2.39–17.04) vs aOR, 1.58 (95% CI, 0.60–4.19)) and cervical incompetence (aOR, 12.79 (95% CI, 2.87–56.93) vs aOR, 4.97 (95% CI, 1.25–19.77)) compared to pregnancies without adenomyosis. The risk of spontaneous preterm birth < 37 weeks and the risk of abnormal fetal presentation was similar between the two subgroups.ConclusionPregnancies complicated by adenomyosis, particularly those with severe adenomyosis, have an increased risk of pregnancy complications, including preterm birth, spontaneous preterm birth, placenta previa, cervical incompetence and abnormal fetal presentation. © 2024 International Society of Ultrasound in Obstetrics and Gynecology.
A Versatile catalytic and photothermal lateral flow immunoassay Based on ultrathin Fe‐MoS2 nanosheets for sensitive and accurate detection of Influenza A
Authors: Xu Meimei , Lin Chenglong , Zhao Shuai , Zhang Weida , Li Dan , Fang Fanghao , Teng Zheng , Peng Yusi , Liu Ming , Huang Zhengren , Shi Jianlin , Yang Yong 
Published: November 2024

AbstractInfluenza A virus (H1N1) poses a significant threat to global human health that imperative demands the development of sensitive and accurate point‐of‐care testing (POCT) methods. Here, for the first time, Fe‐MoS2 nanosheets were employed as a multifunctional nanotag in the development of catalytic colorimetric‐photothermal dual‐mode lateral flow immunoassay (dLFIA) strips for the sensitive detection of H1N1 inactivated virus. The Fe‐MoS2 nanosheets featuring large size, high specific surface area, and ultrathin structure could flow smoothly on the strips and thus quickly produce an ideal colorimetric signal for qualitative analysis. Both the limit of detection (LOD) of catalytic colorimetric and photothermal signals reached 1000 copies/mL and the corresponding calculated LOD was 550 and 691 copies/mL, respectively, which were about 50–90‐fold more sensitive than traditional gold nanoparticles based‐LFIA (5 × 104 copies/mL). The developed assay could correctly identify eight positive clinical samples with Ct values less than 35 and 10 negative actual samples, proving significant promise for rapid, sensitive, and accurate detection of H1N1, especially in resource‐limited areas.
An interesting wall-crossing: failure of the wall-crossing/MMP correspondence
Authors: Rezaee Fatemeh 
Published: November 2024

AbstractWe introduce a novel wall-crossing phenomenon in the space of Bridgeland stability conditions: a wall in the stability space of canonical genus 4 curves that induces non-Q-factorial singularities and hence, it cannot be detected as an operation in the Minimal Model Program of the corresponding moduli space, unlike the case for many surfaces. More precisely, we give an example of a wall-crossing in $$\textrm{D}^{b}(\mathbb {P}^{3})$$

D
b

(

P

3

)

such that the wall induces a small contraction of the moduli space of stable objects associated to one of the adjacent chambers, but a divisorial contraction to the other. This significantly complicates the overall picture in this correspondence to applications of stability conditions to algebraic geometry. The full wall-crossing for canonical genus four curves and the geometry are considered in the published paper (Rezaee in Proc LMS 128(1):e12577, 2024); this article is devoted to describe a particularly interesting wall among the walls in Rezaee (Proc LMS 128(1):e12577, 2024) in full details to explain the novel phenomenon.