bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Irrigation Uniformity Analysis Based on Translation Variable-Rate Sprinkler
Authors: Run Yan 
Published: August 2019

Abstract
Research and compare various modeling of three-dimensional model, the paper chooses CATIA software to model the translation irrigation machine, and analyzes its working principle, structure, mode of operation and obtains to various parts of the structure size parameters, organize and remove redundant parameters, to facilitate the establishment of the model. We proposed here two indexes which were spray shape and water distribution uniformity to evaluate hydraulic performance of variable-rate sprinkler. And analyzed the influence of the throw radius caused by working pressure, nozzle area and trajectory angle. By calculating instantaneous application rate, it is indicated that the irrigation uniformity will go bad when change single factor to accomplish variable-rate irrigation.
Analysis of the precipitated phase changes for Super304H heat resistant steel during shot time aging at 800°C
Authors: Tao Song , Zhiwu Wang 
Published: August 2019

Abstract
For analyzing the change trend of Super304H heat resistant steel steel precipitated phases, this article adopts the method of high temperature aging to simulate the material conditions during actual working environment. Super304H steel aged under 800 °C for short time 10 h, 20 and 30 h. And analyzed SEM morphology, precipitate phase statistics, composition changes of the original sample and the samples after aging. The results showed that the number of precipitated phase increased first, then decreased and then increased with the prolong of aging time, while the average size and area fraction of precipitated phase increased all the time. In the precipitated phase, Cr continued to increase while Ni decreased.
Integrating ab initio and template-based algorithms for protein–protein complex structure prediction
Authors: Vangaveti Sweta , Vreven Thom , Zhang Yang , Weng Zhiping 
Published: August 2019

Abstract

Motivation
Template-based and template-free methods have both been widely used in predicting the structures of protein–protein complexes. Template-based modeling is effective when a reliable template is available, while template-free methods are required for predicting the binding modes or interfaces that have not been previously observed. Our goal is to combine the two methods to improve computational protein–protein complex structure prediction.

Results
Here, we present a method to identify and combine high-confidence predictions of a template-based method (SPRING) with a template-free method (ZDOCK). Cross-validated using the protein–protein docking benchmark version 5.0, our method (ZING) achieved a success rate of 68.2%, outperforming SPRING and ZDOCK, with success rates of 52.1% and 35.9% respectively, when the top 10 predictions were considered per test case. In conclusion, a statistics-based method that evaluates and integrates predictions from template-based and template-free methods is more successful than either method independently.

Availability and implementation
ZING is available for download as a Github repository (https://github.com/weng-lab/ZING.git).

Supplementary information
Supplementary data are available at Bioinformatics online.
Island Nation, US Territory and Contested Space: Territorial Status As a Social Determinant of Indigenous Health in Guam
Authors: Diaz Tressa P , Ka‘opua Lana Sue I , Nakaoka Susan 
Published: August 2019

AbstractThe United Nations and International Federation of Social Work affirm the right of all people to determine their political status, preserve their environments and pursue endeavours for well-being. This article focuses on CHamoru, Guam’s Indigenous people, and examines distal social determinants of health (SDOH) in the contested spaces of US territorial status and non-self-determining Indigenous nationhood. Published multi-disciplinary literature identified ways in which territorial status functions as an SDOH unique to non-self-determining Pacific Island nations. Indicated is the use of structural approaches that address mechanisms of US power and control, including economic policies that ‘defacto’ promote coca-colonisation and non-communicable diseases risk. Critical race theory centres race, colonisation and subversive narratives. In line with fourth-generation SDOH action-oriented research, we posit a CHamoru critical race theory model that weaves Indigenous, social work and public health perspectives. Lack of community input is a limitation of the current research. To assure relevance, the model will be vetted through community discussions. Our discussion guide may be tailored for other Indigenous communities. Social workers may play a meaningful role in promoting health equity through participatory action-oriented, cultural–political social work that upholds Indigenous self-determination and survivance in contested spaces.
Neurotoxic tau oligomers after single versus repetitive mild traumatic brain injury
Authors: Bittar Alice , Bhatt Nemil , Hasan Tasneem F , Montalbano Mauro , Puangmalai Nicha , McAllen Salome , Ellsworth Anna , Carretero Murillo Mariana , Taglialatela Giulio , Lucke-Wold Brandon , Logsdon Aric , Rosen Charles , Turner Ryan C , Kayed Rakez 
Published: August 2019

Abstract
Mild traumatic brain injury accounts for the majority of head injuries and has been correlated with neurodegeneration and dementia. While repetitive mild traumatic brain injury is highly correlated to neurodegeneration, the correlation of a single mild traumatic brain injury with neurodegeneration is still unclear. Because tau aggregates are the main form of mild traumatic brain injury induced pathology, toxic forms of tau protein most likely play a role in the development of post-mild traumatic brain injury neurodegeneration. Therefore, it becomes crucial to characterize the properties of soluble tau aggregates in single versus repetitive mild traumatic brain injury. Herein, we isolated tau oligomers from wild-type mice exposed to single or repetitive mild traumatic brain injury and characterized the tau aggregates at functional, biochemical and biophysical levels. We demonstrated that single versus repetitive mild traumatic brain injuries frequencies lead to the formation of different tau oligomeric polymorphisms. These polymorphisms express different long-term potentiation impairment potencies, toxicity potentials, morphologies and strain indicating properties. To our knowledge, this is the first evidence that soluble tau oligomers derived from single versus repetitive mild traumatic brain injuries form distinct polymorphisms that possibly correlate with the risk of neurodegeneration after mild traumatic brain injury.
Epigenetics of Inflammatory Bowel Disease: Unraveling Pathogenic Events
Authors: Mateos Beatriz , Palanca-Ballester Cora , Saez-Gonzalez Esteban , Moret Inés , Lopez Adrian , Sandoval Juan 
Published: August 2019

Abstract
Epigenetics has emerged as a new and promising field in recent years. Because there exists a need to find new biomarkers and improve diagnosis, prognosis, and drug response for inflammatory bowel diseases, the research on epigenetic biomarkers for molecular diagnostics encourages the translation of this field from the bench to the clinical practice. In this review, we present an overview of the current knowledge and its potential applicability of this emerging field in inflammatory bowel diseases.
Non-invasive in vivo imaging of acute thrombosis: development of a novel factor XIIIa radiotracer
Authors: Andrews Jack P M , Portal Christophe , Walton Tashfeen , Macaskill Mark G , Hadoke Patrick W F , Alcaide Corral Carlos , Lucatelli Christophe , Wilson Simon , Wilson Ian , MacNaught Gillian , Dweck Marc R , Newby David E , Tavares Adriana A S 
Published: August 2019

Abstract

Aims
Cardiovascular thrombosis is responsible a quarter of deaths annually worldwide. Current imaging methods for cardiovascular thrombosis focus on anatomical identification of thrombus but cannot determine thrombus age or activity. Molecular imaging techniques hold promise for identification and quantification of thrombosis in vivo. Our objective was to assess a novel optical and positron-emitting probe targeting Factor XIIIa (ENC2015) as biomarker of active thrombus formation.

Methods and results
Optical and positron-emitting ENC2015 probes were assessed ex vivo using blood drawn from human volunteers and passed through perfusion chambers containing denuded porcine aorta as a model of arterial injury. Specificity of ENC2015 was established with co-infusion of a factor XIIIa inhibitor. In vivo18F-ENC2015 biodistribution, kinetics, radiometabolism, and thrombus binding were characterized in rats. Both Cy5 and fluorine-18 labelled ENC2015 rapidly and specifically bound to thrombi. Thrombus uptake was inhibited by a factor XIIIa inhibitor. 18F-ENC2015 remained unmetabolized over 8 h when incubated in ex vivo human blood. In vivo, 42% of parent radiotracer remained in blood 60 min post-administration. Biodistribution studies demonstrated rapid clearance from tissues with elimination via the urinary system. In vivo,18F-ENC2015 uptake was markedly increased in the thrombosed carotid artery compared to the contralateral patent artery (mean standard uptake value ratio of 2.40 vs. 0.74, P &lt; 0.0001).

Conclusion
ENC2015 rapidly and selectively binds to acute thrombus in both an ex vivo human translational model and an in vivo rodent model of arterial thrombosis. This probe holds promise for the non-invasive identification of thrombus formation in cardiovascular disease.
Does isolated mitral annular calcification in the absence of mitral valve disease affect clinical outcomes after transcatheter aortic valve replacement?
Authors: Okuno Taishi , Asami Masahiko , Khan Faisal , Praz Fabien , Heg Dik , Lanz Jonas , Kassar Mohammad , Khalique Omar K , Gräni Christoph , Brugger Nicolas , Räber Lorenz , Stortecky Stefan , Valgimigli Marco , Windecker Stephan , Pilgrim Thomas 
Published: August 2019

Abstract

Aims
Mitral annular calcification (MAC) has been associated with adverse outcomes in patients undergoing transcatheter aortic valve replacement (TAVR) but has been investigated in isolation of co-existent mitral regurgitation or mitral stenosis, which may represent important confounders. This study sought to investigate the effect of MAC with and without concomitant mitral valve disease (MVD) on clinical outcomes in patients treated with TAVR.

Methods and results
Computed tomography (CT) and echocardiographic data in consecutive TAVR patients enrolled into a prospective registry were categorized according to presence or absence of severe MAC and significant MVD, respectively. A total of 967 patients with adequate CT and echocardiography data were included between 2007 and 2017. Severe MAC was found in 172 patients (17.8%) and associated with MVD in 87 patients (50.6%). Compared to TAVR patients without severe MAC or MVD, all-cause mortality at 1 year was significantly increased among patients with severe MAC in combination with MVD [adjusted hazard ratio (HRadj): 1.97, 95% confidence interval (CI): 1.12–3.44, P = 0.018] and patients with isolated MVD (HRadj: 2.33, 95% CI: 1.56–3.47, P &lt; 0.001), but not in patients with isolated severe MAC in the absence of MVD (HRadj: 0.52, 95% CI: 0.21–1.33, P = 0.173).

Conclusion
We found no effect of isolated MAC on clinical outcomes following TAVR in patients with preserved mitral valve function. Patients with MVD had an increased risk of death at 1 year irrespective of MAC.
Temporal trends in bleeding events in acute myocardial infarction: insights from the SWEDEHEART registry
Authors: Simonsson Moa , Wallentin Lars , Alfredsson Joakim , Erlinge David , Hellström Ängerud Karin , Hofmann Robin , Kellerth Thomas , Lindhagen Lars , Ravn-Fischer Annica , Szummer Karolina , Ueda Peter , Yndigegn Troels , Jernberg Tomas 
Published: August 2019

Abstract

Aims
To describe the time trends of in-hospital and out-of-hospital bleeding parallel to the development of new treatments and ischaemic outcomes over the last 20 years in a nationwide myocardial infarction (MI) population.

Methods and results
Patients with acute MI (n = 371 431) enrolled in the SWEDEHEART registry from 1995 until May 2018 were selected and evaluated for in-hospital bleeding and out-of-hospital bleeding events at 1 year. In-hospital bleeding increased from 0.5% to a peak at 2% 2005/2006 and thereafter slightly decreased to a new plateau around 1.3% by the end of the study period. Out-of-hospital bleeding increased in a stepwise fashion from 2.5% to 3.5 % in the middle of the study period and to 4.8% at the end of the study period. The increase in both in-hospital and out-of-hospital bleeding was parallel to increasing use of invasive strategy and adjunctive antithrombotic treatment, dual antiplatelet therapy (DAPT), and potent DAPT, while the decrease in in-hospital bleeding from 2007 to 2010 was parallel to implementation of bleeding avoidance strategies. In-hospital re-infarction decreased from 2.8% to 0.6% and out-of-hospital MI decreased from 12.6% to 7.1%. The composite out-of-hospital MI, cardiovascular death, and stroke decreased in a similar fashion from 18.4% to 9.1%.

Conclusion
During the last 20 years, the introduction of invasive and more intense antithrombotic treatment has been associated with an increase in bleeding events but concomitant there has been a substantial greater reduction of ischaemic events including improved survival.
A novel Sphingobacterium sp. RB, a rhizosphere isolate degrading para-nitrophenol with substrate specificity towards nitrotoluenes and nitroanilines
Authors: Samson Rachel , Bodade Ragini , Zinjarde Smita , Kutty Razia 
Published: August 2019

ABSTRACT
Sphingobacterium sp. RB, a novel bacterial strain isolated from a soil sample, was able to utilize para-nitrophenol (PNP) as sole source of carbon and energy at high concentrations (1.0–5.0 mM). The culture completely degraded 3.0 mM PNP within 36 h with proportionate increase in biomass. With 5.0 mM PNP (700 ppm), 70% degradation was observed within 72 h of incubation. Scanning electron microscope images of the isolate in the presence and absence of PNP showed no significant morphological variations. Liquid chromatography–mass spectrometry analysis indicated that the biodegradation of PNP in this bacterium proceeded via the formation of 1,2,4-benzenetriol. Cells previously exposed to PNP (induced) were 30% more effective in degrading PNP. With catechol and phenol, such induction was not observed. Uninduced cells of Sphingobacterium sp. RB were capable of degrading a variety of other nitroaromatic compounds, including 2-nitroaniline, 2,4-dinitroaniline, 2-nitrotoluene, 3-nitrotoluene and 2,4-dinitrophenol, within 72 h, thus proving its candidacy as a potent bioremediation agent. To the best of our knowledge, this is the first report on a Sphingobacterium species degrading PNP via formation of 1,2,4-benzenetriol.
The correlation between microRNAs and Helicobacter pylori in gastric cancer
Authors: Dastmalchi Narges , Safaralizadeh Reza , Banan Khojasteh Seyed Mahdi 
Published: August 2019

ABSTRACT
Helicobacter pylori infection and H. pylori-related gastric inflammation can be considered as the most significant promoter of gastric cancer (GC). Recent investigations have evaluated the regulatory function of microRNAs (miRNAs) in H. pylori pathogenesis and H. pylori-related diseases, especially GC. The present study reviewed the correlation between miRNAs and H. pylori in gastrointestinal diseases. Furthermore, the current review highlighted the role of H. pylori pathogen and some H. pylori-related virulence factors in the deregulation of various miRNAs, especially oncogenic miRNAs (miRs) and their associated molecular pathways. Among the related studies, some have focused on the effects of H. pylori infection on regulatory networks of miRs, while others have highlighted the effects of alterations in the expression level of miRs in H. pylori-related diseases. The connectivity between miRNAs and H. pylori is regulated by various molecular pathways and different molecular targets of miRNAs.
A Manin–Mumford Theorem for the Maximal Compact Subgroup of a Universal Vectorial Extension of a Product of Elliptic Curves
Authors: Jones Gareth , Schmidt Harry 
Published: August 2019

Abstract
We study the intersection of an algebraic variety with the maximal compact subgroup of a universal vectorial extension of a product of elliptic curves. For this intersection we show a Manin–Mumford-type statement. This answers some questions posed by Corvaja–Masser–Zannier, which arose in connection with their investigation of the intersection of an algebraic curve with the maximal compact subgroup of various algebraic groups. In particular they proved that these intersections are finite for universal vectorial extensions of elliptic curves. Using Khovanskii’s zero-estimates combined with a stratification result of Gabrielov–Vorobjov and recent work of the authors, we obtain effective bounds for this intersection that only depend on the degree of the algebraic variety and the dimension of the group. As a corollary, we obtain new uniform results of Manin–Mumford type for additive extensions of certain abelian varieties.
Universal Behavior of the Corners of Orbital Beta Processes
Authors: Cuenca Cesar 
Published: August 2019

Abstract
There is a unique unitarily-invariant ensemble of $N\times N$ Hermitian matrices with a fixed set of real eigenvalues $a_1&gt; \dots &gt; a_N$. The joint eigenvalue distribution of the $(N-1)$ top-left principal submatrices of a random matrix from this ensemble is called the orbital unitary process. There are analogous matrix ensembles of symmetric and quaternionic Hermitian matrices that lead to the orbital orthogonal and symplectic processes, respectively. By extrapolation, on the dimension of the base field, of the explicit density formulas, we define the orbital beta processes. We prove the universal behavior of the virtual eigenvalues of the smallest $m$ principal submatrices, when $m$ is independent of $N$ and the eigenvalues $a_1&gt; \dots &gt; a_N$ grow linearly in $N$ and in such a way that the rescaled empirical measures converge weakly. The limiting object is the Gaussian beta corners process. As a byproduct of our approach, we prove a theorem on the asymptotics of multivariate Bessel functions.
Staphylococcus aureus from hospital-acquired pneumonia from an Italian nationwide survey: activity of ceftobiprole and other anti-staphylococcal agents, and molecular epidemiology of methicillin-resistant isolates
Authors: Antonelli Alberto , Giani Tommaso , Coppi Marco , Di Pilato Vincenzo , Arena Fabio , Colavecchio Olga Lorenza , Conte Viola , Santerre Henriksen Anne , Rossolini Gian Maria ,   MRSA-HAP Study Group, Principe Luigi , Pagani Elisabetta , Galanti Irene , Scarparo Claudio , Vaggelli Guendalina , Mencacci Antonella , Orecchioni Francesca , Fontana Carla , Labonia Maria , Bianco Gabriele , Sambri Vittorio , Campanile Floriana , Bielli Alessandra 
Published: August 2019

AbstractObjectivesTo determine the prevalence of Staphylococcus aureus from hospital-acquired pneumonia (HAP) in Italy and the susceptibility to ceftobiprole and comparators of MSSA and MRSA isolates. A secondary objective was to characterize the clonality and acquired resistance and virulence genes of MRSA.MethodsConsecutive non-replicate isolates from HAP were collected from 13 laboratories distributed across Italy, from January to May 2016. Antimicrobial susceptibility testing was performed by broth microdilution, and results were interpreted according to the EUCAST breakpoints. All MRSA isolates were subjected to WGS using an Illumina platform. Clonality and resistance and virulence gene content were investigated with bioinformatics tools.ResultsAmong 333 isolates from HAP, S. aureus was the third most common pathogen (18.6%). The proportion of MRSA was 40.3%. Susceptibility to ceftobiprole was 100% for MSSA and 95.5% for MRSA. Lower susceptibility rates of 78.4% and 94.6% in MSSA and 36.4% and 12.1% in MRSA isolates were observed for erythromycin and levofloxacin, respectively. The MRSA from HAP mostly belonged to clonal complex (CC) 22 (47.0%), CC5 (25.8%) and CC8 (15.2%), with a minority of other lineages (ST1, ST6, ST7, ST30, ST152 and ST398). Acquired resistance and virulence genes in most cases exhibited a clonal distribution. The three ceftobiprole-resistant isolates exhibited an MIC of 4 mg/L and belonged to ST228-MRSA-I of CC5.ConclusionsS. aureus is an important cause of HAP in Italy. Ceftobiprole exhibited good in vitro activity against S. aureus isolated from HAP, including MRSA. A trend to replacement of ST228 with ST22 was noticed compared with previous studies.
Subgroup analysis of Japanese patients in a Phase 3 study of atezolizumab in advanced triple-negative breast cancer (IMpassion130)
Authors: Iwata Hiroji , Inoue Kenichi , Kaneko Koji , Ito Yoshinori , Tsugawa Koichiro , Hasegawa Ayumi , Nakagawa Shintaro , Kuratomi Hiroyasu , Tamura Kenji 
Published: August 2019

AbstractBackgroundIn the randomised Phase 3 IMpassion130 trial, atezolizumab combined with nab-paclitaxel (atezo + nab-P) in 902 patients with triple-negative breast cancer (TNBC) showed prolonged progression-free survival (PFS) in both the intention-to-treat (ITT) population and programmed death-ligand 1 (PD-L1)–positive subgroup compared with placebo plus nab-P (plac + nab-P). This study assessed the efficacy and safety of atezo + nab-P in the IMpassion130 Japanese subpopulation.MethodsEligible patients had unresectable locally advanced or metastatic TNBC previously untreated with chemotherapy for metastatic disease. Patients were randomised 1:1 to receive either atezo + nab-P or plac + nab-P. Co-primary endpoints were investigator-assessed PFS and overall survival (ITT population and PD-L1–positive subgroup). These were also assessed in the Japanese subpopulation.ResultsThere were 65 Japanese patients (34 atezo + nab-P; 31 plac + nab-P). The PD-L1–positive subgroup included 25 patients (12 atezo + nab-P; 13 plac + nab-P). Median PFS was 7.4 months (atezo + nab-P) versus 4.6 months (plac + nab-P; hazard ratio [HR], 0.47; 95% CI, 0.25–0.90). In the PD-L1–positive subgroup, median PFS was 10.8 months (atezo + nab-P) versus 3.8 months (plac + nab-P; HR, 0.04; 95% CI, &lt;0.01–0.35). Safety results in the Japanese subgroup were consistent with those in the overall population. The Japanese subgroup had a lower incidence of adverse events leading to treatment withdrawal than the overall population. More patients in the atezo + nab-P arm had neutrophil count decreases and stomatitis than patients in the plac + nab-P arm.ConclusionsAtezo + nab-P efficacy in Japanese patients was consistent with the overall IMpassion130 population. No new safety signals were observed, and tolerability was consistent with that of the overall population.
One Parent, Three Parents: Judges and Ontario’s All Families Are Equal Act, 2016
Authors: Leckey Robert 
Published: August 2019

AbstractThis article studies judges’ early treatment of a new law on parentage and assisted reproduction. During decades of legislative inaction, Ontario’s judges adapted the law to evolving familial practices, at times boldly. A legislative overhaul in 2016, aiming to recognize all children’s families equally and inclusively, raised the question whether judges would adopt a more restrained role post-reform. In two early cases, where the new conditions for automatic recognition of a parental arrangement were unmet, the judges emphasized the intention of involved adults. Closely reading the legislation, the article presents bases for deciding the cases otherwise and for reducing their potential to incentivize litigation. Where the legislature has set out a broad range of accessible paths to parentage, even judges who champion family diversity may have reasons to stick to those paths. For legislative drafters, the difficulty of anticipating the variety of contemporary forms of family may counsel against purporting to limit judicial discretion. Ontario’s experience also favours including transitional measures in major reform.