bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraday order placement and execution in a limit order market: Evidence from the Indonesia stock market
Authors: Ekaputra Irwan A. , Liu Chunlin , Rhee S. Ghon , Zeng Hongchao 
Published: July 2019

AbstractUsing order and trade information from the Jakarta Stock Exchange (JSX), we examine the intraday patterns of order placement and execution. We find that the probability of an order being executed is the lowest in the first trading hour even though more than 50% of orders are submitted during the period. The execution probability increases steadily along the trading hours and reaches the highest close to the end of trading. Controlling for order aggressiveness and other factors that might impact investors' order placement behavior, we find that orders placed in the morning take longer to be executed compared to those submitted in the afternoon. However, the execution cost is relatively lower for orders of early trading. Our results suggest that choosing the right time to place an order is important in designing an optimal trading strategy.
Case records from the 13th annual international symposium on ventricular arrhythmias
Authors: Pathik Bhupesh , Dukkipati Srinivas , Syros Geroge , Reddy Vivek Y. , Koruth Jacob 
Published: July 2019

AbstractA 60‐year old male with a history of nonischemic cardiomyopathy and the high burden of premature ventricular contractions (PVCs) was evaluated for possible PVC‐induced cardiomyopathy.
Bipolar ablation of epicardial posteroseptal accessory pathway
Authors: Derejko Pawel , Miszczak‐Knecht Maria , Sliwka Michal , Dzwonkowska Dobromiła , Bieganowska Katarzyna 
Published: July 2019

AbstractWe present a case of a 16‐year‐old male with WPW syndrome, referred for ablation after being resuscitated from cardiac arrest. Bipolar transseptal RF ablation successfully destroyed rapidly conducting epicardial posteroseptal accessory pathway after three failed attempts of endo‐ and epicardial ablation.
Procyanidin B2 inhibits the activation of hepatic stellate cells and angiogenesis via the Hedgehog pathway during liver fibrosis
Authors: Feng Jiao , Wang Chengfen , Liu Tong , Li Jingjing , Wu Liwei , Yu Qiang , Li Sainan , Zhou Yuting , Zhang Jie , Chen Jiaojiao , Ji Jie , Chen Kan , Mao Yuqing , Wang Fan , Dai Weiqi , Fan Xiaoming , Wu Jianye , Guo Chuanyong 
Published: July 2019

AbstractBackgroundLiver fibrosis is a wound‐healing process of liver featured by the over‐deposition of extracellular matrix (ECM) and angiogenesis. However, the effective treatment is lacking. Procyanidin B2 (PB2) is a flavonoid extract abundant in grape seeds with anti‐oxidant, anti‐inflammatory and anti‐cancer properties. The present study aimed to determine effects of PB2 on liver fibrosis.MethodThe CCl4‐induced mouse liver fibrosis model and a human hepatic stellate cell (HSC) line (LX2 cells) were used to study the activation, ECM production and angiogenesis of HSCs through Western blotting analysis, immunohistochemistry, immunofluorescence staining, flow cytometry and tubulogenesis assay. A Hedgehog (Hh) pathway inhibitor (cyclopamine) and Smoothened agonist (SAG) were used to investigate the role of PB2 on Hh pathway.ResultsThe results showed that PB2 could inhibit the proliferation and induce apoptosis of HSCs. PB2 could also down‐regulate the expressions of VEGF‐A, HIF‐1α, α‐SMA, Col‐1 and TGF‐β1 of HSCs in vivo and in vitro. The application of SAG and cyclopamine proved that PB2 targets on Hh pathway.ConclusionsPB2 inhibited the Hh pathway to suppress the activation, ECM production and angiogenesis of HSCs, therefore reverses the progression of liver fibrosis in vivo and in vitro.
Effect of WAM‐1 transgenic Arabidopsis thaliana on the development and gut microbial composition of diamondback moth (Plutella xylostella) larvae (Lepidoptera: Plutellidae)
Authors: Wu Yafei , Jayasekara Arachchige Maduka Nilakshi , Pei Xiaoya , Wang Dun 
Published: July 2019

AbstractWAM‐1 is a cathelicidin antimicrobial peptide found on the Macropus eugenii (Tammar wallaby) genome. It possesses antibiotic activity against a broad spectrum of bacteria and fungi. In order to investigate the impact of this WAM‐1 antimicrobial peptide on development and midgut microbial composition of Plutella xylostella (DBM) larvae, the WAM‐1 was introduced into Arabidopsis thaliana using the Agrobacterium‐mediated floral‐dip transformation method. WAM‐1 expression was confirmed by reverse transcriptase PCR analysis. The larval growth and developmental variations and midgut microbial compositions were analysed after DBM larvae had fed on transgenic plants. Transgenic plant‐fed DBM larvae showed significantly higher mortality, a prolonged developmental period and less weight gain. Enterobacteriaceae was the highest dominating family in all samples including transgenic and non‐transgenic plants fed larvae. However, its abundance was substantially lower in the WAM‐1 Arabidopsis‐fed larvae. Furthermore, Moraxellaceae and Bacillaceae were the next dominating families in the WAM‐1 transgenic Arabidopsis‐fed larvae whereas Enterococcaceae and Xanthomonadaceae were dominant in the non‐transgenic Arabidopsis‐fed larvae. Abundance of Pseudomonadaceae was also relatively higher in WAM‐1 transgenic‐fed larvae whereas it was much lower in other samples. Therefore, our findings suggest that WAM‐1 has an impact on gut microbial composition but a minor effect on larval development.
Distribution models for Ascia monuste and the host Brassica oleracea var. capitata
Authors: Santos Abraão Almeida , Hogendoorn Katja , Ramos Rodrigo Soares , Picanço Marcelo Coutinho 
Published: July 2019

AbstractThe butterfly Ascia monuste L. (Lepidoptera: Pieridae) is a specialist pest of brassica crops in neotropical regions where it significantly impacts crop production. Understanding the actual and potential distribution of the pest and its hosts in current and future climates may help government agencies to mitigate and manage potential incursions. Here, we use MaxEnt algorithm to model the current distribution of both A. monuste and its host, Brassica oleracea var. capitata L. (cabbage) and then model the likely impact of projected climate change (RCP 4.5 and 8.5 scenarios) on their potential future distributions. While A. monuste is currently restricted to the American continent, we show that under current conditions the potential distribution of both the butterfly and cabbage includes areas of Africa, Asia, Oceania and Europe to some extent. The annual temperature range and mean annual temperature were the strongest predictors of the distribution of both species. Under a projected climate change scenario, suitable areas in the tropical climate zone are expected to decrease for both species. However, in temperate regions, the suitable area for cabbage is expected to increase but will remain unsuitable for the pest. Our results highlight the need for strategies to prevent the introduction of A. monuste to other areas of the tropical climate zone and for the development of management practices in the neotropical region.
Salinity affects growth but not thermal preference of adult mummichogs Fundulus heteroclitus
Authors: Thompson Jessica S. 
Published: July 2019

AbstractThe effects of an ecologically relevant range of salinities (2, 12, 22, 32) on thermal preferences and growth of adult mummichogs Fundulus heteroclitus were determined for fish from a southern Chesapeake Bay population. Salinity did not affect the mean temperature selected by F. heteroclitus in a thermal gradient, which was identified as 26.6°C based on observations of 240 individuals. Salinity and temperature had significant and interacting effects on growth rates of F. heteroclitus measured over 12 weeks. Growth rates were highest overall and remained high over a broader range of temperatures at moderate salinities (12 and 22), while high growth rates were shifted toward lower temperatures for fish grown at a salinity of 2 and higher temperatures at a salinity of 32. Significant reductions in growth relative to the optimal conditions (28.6°C, salinity of 22) were observed at the coolest (19.6°C) and warmest (33.6°C) temperature tested at all salinities, as well as temperatures ≥ 26.6°C at a salinity of 2, ≥ 28.6°C at a salinity of 12 and ≤ 26.6°C at a salinity of 32. Growth rates provide a long‐term, organismal measure of performance and results of this study indicate that performance may be reduced under conditions that the highly euryhaline F. heteroclitus can otherwise easily tolerate. The combination of reduced salinity and increased temperature that is predicted for temperate estuaries as a result of climate change may have negative effects on growth of this ecologically important species.
The effect of botulinum toxin type A in different dilution on the contraction of fibroblast—In vitro study
Authors: Wanitphakdeedecha Rungsima , Kaewkes Arisa , Ungaksornpairote Chanida , Limsaengurai Saowalak , Panich Uraiwan , Manuskiatti Woraphong 
Published: July 2019

AbstractBackgroundBotulinum toxin type A (BoNT‐A) may directly remodel dermal tissues or induce a loss of normal morphology and cytoplasmic retraction and spread. Intradermal injection was claimed to produce a dermo‐lifting effect, including midface lifting by using low concentration with variable dilution.ObjectiveTo understand how intradermal BoNT‐A achieves tissue lifting, we examined different type of BoNT‐A and their effects on dermal fibroblast contraction.MethodsNormal human dermal fibroblasts were treated with onabotulinumtoxin (ONA), abobotulinumtoxin (ABO), prabotulinumtoxinA (PRABO), incobotulinumtoxinA (INCO), and letibotulinumtoxin A (LETI) in dilutions used in real‐world practice. Fifty fibroblasts per dilution were photographed and measured the length to demonstrate their contraction every 2 hours from baseline (0 hours) to 12 hours post‐treatment.ResultsONA did not significantly decrease fibroblast lengths, at any timepoint or dilution. At 1:7 dilution ratios, ABO decreased fibroblast lengths after 2 hours and significantly after 10‐12 hours. At 1:7, 1:8, 1:9, and 1:10 dilution, PRABO decreased length, and most rapidly at 1:7 and 1:8. At 1:6, 1:8, 1:9, and 1:10 dilution, INCO decreased lengths almost immediately. At 1:6 dilution, INCO decreased lengths almost immediately. At 1:7 dilution, INCO decreased lengths after 2‐4 hours, while at 1:8, 1:9, and 1:10 dilution, INCO decreased lenghts nearly imediately. LETI decreased lengths at all dilutions except 1:9, with near‐immediate effects at 1:6, 1:7, 1:8, and 1:10. At 1:4 dilution, LETI decreased lengths from 1 hour.ConclusionsDifferent commercial preparations of BoNT‐A toxins cause different fibroblast contractions in vitro. Product selection and dilution used may affect the clinical outcome of intradermal injection of BoNT‐A for face lifting.
Population genetics and evolutionary history of Miscanthus species in China
Authors: Li Shan‐Shan , Zhou Hai‐Fei , Chen Wen‐Li , Yan Juan , Cai Zhe , Wei Ruo‐Xun , Chen Chih‐Hui , Han Bin , Li Jian‐Qiang , Sang Tao , Ge Song 
Published: July 2019

AbstractMiscanthus species have received considerable attention as a potential biomass source for renewable energy production because of their ability to produce high yields of biomass and adapt to a wide range of climates and soils. To explore the genetic diversity and phylogenetic relationship of Miscanthus species in China, we used 24 simple sequence repeat markers to genotype 100 natural populations representing all four Chinese Miscanthus species (M. sinensis Andersson, M. floridulus (Lab.) Warb. ex K. Schum. & Lauterb., M. sacchariflorus (Maxim.) Hack., and M. lutarioriparius L. Liu ex Renvoize & S. L. Chen). Based on phylogenetic, principal coordinate, and Structure analyses, we found that the 100 populations formed two major groups corresponding to sect. Triarrhena and sect. Miscanthus. Group 1 (i.e., sect. Triarrhena) was further subdivided into two subgroups corresponding to M. sacchariflorus and M. lutarioriparius; Group 2 (i.e., sect. Miscanthus) was subdivided into three subgroups, group 2a (M. sinensis populations in southern China), group 2b (M. sinensis populations in northern China), and group 2c (all the M. floridulus populations). Population genetics analyses indicated high levels of the genetic diversity at both population (HE = 0.468–0.599) and species (HE = 0.559–0.708) levels, indicative of the potential of these wild resources in future breeding programs. The species distribution modeling showed that M. sacchariﬂorus and M. lutarioriparius have experienced population reductions during the last glacial maximum and population expansion afterward; in contrast, M. sinensis and M. floridulus both underwent gradual population expansions from the last interglaciation to the present. We also suggest that M. floridulus originated from M. sinensis in southeast China through ecological speciation. The understanding of the evolutionary history and population dynamics of these species not only provides valuable information for further genetic improvement and breeding of this energy crop but also gives important insights into the origin and speciation processes of the Miscanthus species.
New insights into the phylogeny and biogeography of subfamily Orontioideae (Araceae)
Authors: Lee Joon Seon , Kim Seon‐Hee , Lee Sangryong , Maki Masayuki , Otsuka Koichi , Kozhevnikov Andrey E. , Kozhevnikova Zoya V. , Wen Jun , Kim Seung‐Chul 
Published: July 2019

AbstractProto‐Araceae, the earliest diverged lineage within the family Araceae, includes two subfamilies, Gymnostachydoideae (one species) and Orontioideae (eight species). Based on an extensive sampling (a total of 198 accessions) of six chloroplast non‐coding regions (5799 aligned sites), we assessed phylogenetic relationships among the genera and species within subfamily Orontioideae and estimated the timing of intercontinental disjunct events in the Northern Hemisphere. Overall phylogenetic relationships among the genera were consistent with results from previous studies, but several new important findings were discovered, primarily within Symplocarpus Salisb. ex W. P. C. Barton. First, two major lineages within Symplocarpus were identified: one lineage included S. foetidus (L.) Salisb. ex W. Barton, S. nabekuraensis Otsuka & K. Inoue, and S. renifolius Schott ex Tzvelev (Japan), whereas the other included S. nipponicus Makino, S. egorovii N. S. Pavlova & V. A. Nechaev, and S. renifolius (Korea). Symplocarpus renifolius in Japan was tetraploid and closely related to the tetraploid S. foetidus in eastern North America. Populations of S. renifolius in Korea were confirmed to be diploid (2n = 30) and shared the most recent common ancestor with the other diploid species, S. nipponicus. Second, two recently described species, S. nabekuraensis and S. egorovii, were deeply embedded within S. renifolius in Japan and Korea, respectively, and their distinct taxonomic status requires further assessment. Finally, two intercontinental disjunction events in the subfamily, one in Lysichiton Schott between eastern Asia and western North America and the other in Symplocarpus between eastern Asia and eastern North America, were estimated to be between 4.5 and 1.4 million years ago (Pliocene and Pleistocene) and between 1.9 and 0.5 million years ago (Pleistocene), respectively.
Genome‐wide variation in DNA methylation is associated with stress resilience and plumage brightness in a wild bird
Authors: Taff Conor C. , Campagna Leonardo , Vitousek Maren N. 
Published: July 2019

AbstractIndividuals often differ in their ability to cope with challenging environmental and social conditions. Evidence from model systems suggests that patterns of DNA methylation are associated with variation in coping ability. These associations could arise directly if methylation plays a role in controlling the physiological response to stressors by, among other things, regulating the release of glucocorticoids in response to challenges. Alternatively, the association could arise indirectly if methylation and resilience have a common cause, such as early‐life conditions. In either case, methylation might act as a biomarker for coping ability. At present, however, relatively little is known about whether variation in methylation is associated with organismal performance and resilience under natural conditions. We studied genome‐wide patterns of DNA methylation in free‐living female tree swallows (Tachycineta bicolor) using methylated DNA immunoprecipitation (MeDIP) and a tree swallow genome that was assembled for this study. We identified areas of the genome that were differentially methylated with respect to social signal expression (breast brightness) and physiological traits (ability to terminate the glucocorticoid stress response through negative feedback). We also asked whether methylation predicted resilience to a subsequent experimentally imposed challenge. Individuals with brighter breast plumage and higher stress resilience had lower methylation at differentially methylated regions across the genome. Thus, widespread differences in methylation predicted both social signal expression and the response to future challenges under natural conditions. These results have implications for predicting individual differences in resilience, and for understanding the mechanistic basis of resilience and its environmental and social mediators.
The roles of age, parentage and environment on bacterial and algal endosymbiont communities in Acropora corals
Authors: Chan Wing Yan , Peplow Lesa M. , Menéndez Patricia , Hoffmann Ary A. , van Oppen Madeleine J. H. 
Published: July 2019

AbstractThe bacterial and microalgal endosymbiont (Symbiodiniaceae spp.) communities associated with corals have important roles in their health and resilience, yet little is known about the factors driving their succession during early coral life stages. Using 16S rRNA gene and ITS2 metabarcoding, we compared these communities in four Acropora coral species and their hybrids obtained from two laboratory crosses (Acropora tenuis × Acropora loripes and Acropora sarmentosa × Acropora florida) across the parental, recruit (7 months old) and juvenile (2 years old) life stages. We tested whether microbiomes differed between (a) life stages, (b) hybrids and purebreds, and (c) treatment conditions (ambient/elevated temperature and pCO2). Microbial communities of early life stage corals were highly diverse, lacked host specificity and were primarily determined by treatment conditions. Over time, a winnowing process occurred, and distinct microbial communities developed between the two species pair crosses by 2 years of age, irrespective of hybrid or purebred status. These findings suggest that the microbial communities of corals have a period of flexibility prior to adulthood, which can be valuable to future research aimed at the manipulation of coral microbial communities.
Time‐Varying Relationship between Inflation and Inflation Uncertainty
Authors: Hou Chenghan 
Published: July 2019

AbstractThis paper investigates whether the relationship between inflation and inflation uncertainty has changed and whether the change in this relationship has been gradual or abrupt. We extend the time‐varying parameter with stochastic volatility in mean model (TVP‐SVM) to include a mixture innovation disturbance in the time‐varying parameter process. The proposed model produces more reliable estimates and allows us to investigate the occurrence of breaks in the gradually evolving process of the time varying coefficients. Using data of US, Germany, Canada, New Zealand, UK, France, Italy, Spain and Australia, we find that: (i) the relationship between inflation and inflation uncertainty substantially varies over time; (ii) there is strong support for the existence of abrupt changes in the US inflation–inflation uncertainty relationship; (iii) our empirical results of Canada and New Zealand show that the correlation between inflation and inflation uncertainty has been much weaker since early 1990s, which coincides with the timing of the implementation of inflation targeting.
A comparison of the healthiness of packaged foods and beverages from 12 countries using the Health Star Rating nutrient profiling system, 2013–2018
Authors: Dunford Elizabeth K. , Ni Mhurchu Cliona , Huang Liping , Vandevijvere Stefanie , Swinburn Boyd , Pravst Igor , Tolentino‐Mayo Lizbeth , Reyes Marcela , L'Abbé Mary , Neal Bruce C. 
Published: July 2019

SummaryWe compared the healthiness of packaged foods and beverages between selected countries using the Health Star Rating (HSR) nutrient profiling system. Packaged food and beverage data collected 2013–2018 were obtained for Australia, Canada, Chile, China, India, Hong Kong, Mexico, New Zealand, Slovenia, South Africa, the UK, and USA. Each product was assigned to a food or beverage category and mean HSR was calculated overall by category and by country. Median energy density (kJ/100 g), saturated fat (g/100 g), total sugars (g/100 g) and sodium (mg/100 g) contents were calculated. Countries were ranked by mean HSR and median nutrient levels. Mean HSR for all products (n = 394,815) was 2.73 (SD 1.38) out of 5.0 (healthiest profile). The UK, USA, Australia and Canada ranked highest for overall nutrient profile (HSR 2.74–2.83) and India, Hong Kong, China and Chile ranked lowest (HSR 2.27–2.44). Countries with higher overall HSR generally ranked better with respect to nutrient levels. India ranked consistently in the least healthy third for all measures. There is considerable variability in the healthiness of packaged foods and beverages in different countries. The finding that packaged foods and beverages are less healthy in middle‐income countries such as China and India suggests that nutrient profiling is an important tool to enable policymakers and industry actors to reformulate products available in the marketplace to reduce the risk of obesity and NCDs among populations.
Estimating stomatal and biochemical limitations during photosynthetic induction
Authors: Deans Ross M. , Farquhar Graham D. , Busch Florian A. 
Published: July 2019

AbstractUnderstanding stomatal and biochemical components that limit photosynthesis under different conditions is important for both the targeted improvement of photosynthesis and the elucidation of how stomata and biochemistry affect plant performance in an ecological context. Limitation analyses have not yet been extensively applied to conditions of photosynthetic induction after an increase in irradiance. Moreover, few studies have systematically assessed how well various limitation analyses actually work. Here we build on two general ways of estimating limitations, one that sequentially removes the effect of a limitation (elimination) and one that uses a tangent plane approximation (differential), by including the ternary effect and boundary layer conductance so that they are consistent with gas exchange data. We apply them to the analysis of temporal and time‐integrated limitations during photosynthetic induction, calculating limitations either independent of the time course (one‐step) or make use of the entire time course (stepwise). We show that the stepwise differential method is the best method to use when time steps are small enough. We further show that the differential method predicts limitations near exact when the internal CO2 concentration stays constant. This last insight has important implications for the general use of limitation analyses beyond photosynthetic induction.