bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Nomogram Based on Histological Characteristics of Fibrotic Tumor Stroma in Patients Who Underwent Curative Resection for Intrahepatic Cholangiocarcinoma
Authors: Jing Chu-Yu , Fu Yi-Peng , Huang Jin-Long , Zhang Mei-Xia , Yi Yong , Gan Wei , Xu Xin , Shen Hu-Jia , Lin Jia-Jia , Zheng Su-Su , Zhang Juan , Zhou Jian , Fan Jia , Ren Zheng-Gang , Qiu Shuang-Jian , Zhang Bo-Heng 
Published: September 2018

Abstract

Background
Fibrotic tumor stroma (FTS) has been implicated in cancer promotion in several neoplasms. The histological features of FTS are convenient and easily accessible in clinical routine in intrahepatic cholangiocarcinoma (ICC) specimens. The goal of this study was to explore prognostic impacts of the quantity and maturity of FTS on surgical ICC patients. Moreover, we aimed to propose an efficient prognostic nomogram for postoperative ICC patients.

Materials and Methods
The clinical profiles of 154 consecutive postoperative ICC patients were retrospectively analyzed. Tumor-stroma ratio and morphological maturity of FTS were evaluated on hematoxylin and eosin-stained tumor sections. CD3, CD8, and α-smooth muscle actin (α-SMA) staining were performed on corresponding tissue microarrays. The nomogram was established on variables selected by multivariate analyses and was validated in 10-fold cross-validation.

Results
Rich tumor stroma and strong α-SMA expression were associated with poor overall survival (OS). However, in multivariate analyses, these two biomarkers failed to stratify both OS and recurrence-free survival (RFS). Immature FTS was correlated with tumor multiplicity, advanced clinical stage, and sparser CD3 and CD8 positive tumor-infiltrating lymphocytes (TILs) and was identified as an independent prognostic indicator for both OS and RFS. The nomogram comprising FTS maturity, tumor number, microvascular invasion, and lymph node metastasis possessed higher predictive power relative to conventional staging systems.

Conclusion
Immature FTS was an independent risk factor for survival and was associated with sparser CD3 and CD8 positive TILs in ICC. The prognostic nomogram integrating the maturity of FTS offers a more accurate risk stratification for postoperative ICC patients.

Implications for Practice
Accumulating evidence has suggested that fibrotic components in tumor microenvironment (TME) play a complicated and vital role in TME reprogramming and cancer progression. However, in clinical practice, the evaluation of fibrotic tumor stroma (FTS) is still neglected to some extent. This study's findings indicated that, in intrahepatic cholangiocarcinoma (ICC), the histological maturity of FTS is a robust prognostic indicator for patients who underwent curative resection. Moreover, prognostic nomogram constructed on the maturity of FTS possessed higher predictive power relative to the conventional tumor-node-metastasis staging systems. Taken together, the evaluation of FTS should be emphasized in clinical routine for more accurate prognostic prediction in postoperative ICC patients.
Cosmetic Consequences of Breast-Conserving Treatment for Breast Cancer: Something Worth Talking About
Authors: Brands-Appeldoorn Angelique , Maaskant-Braat Sabrina , Schenk Karin , Roumen Rudi 
Published: September 2018

AbstractBackgroundBreast-conserving treatment (BCT) for breast cancer can lead to deformation of the treated breast, resulting in patient dissatisfaction with the final cosmetic outcome. Currently, literature on the specific information needs of patients concerning the cosmetic effects of BCT is lacking. The aim of the present study was to investigate the information needs of breast cancer patients regarding the long-term cosmetic outcome after BCT.Subjects, Materials, and MethodsThe data from 115 women who had undergone BCT in a general teaching hospital breast cancer unit in The Netherlands were studied. Structured questionnaires and semi-structured interviews were conducted between October 2012 and April 2013. A mixed model of quantitative and qualitative research was used to explore patient-reported information needs. A phenomenological approach was used to analyze the qualitative data.ResultsThis study shows that women undergoing BCT want to discuss long-term cosmetic effects. Most patients appreciate such information immediately after the diagnosis. Patients indicated that it is also important to pay attention to the cosmetic effects during the follow-up visits, because deformation of the breast can also occur at a later stage. Furthermore, half the patients indicated that they would not likely raise the subject of cosmetic effects of the treatment themselves.ConclusionBreast cancer patients have a need for long-term attention for cosmetic outcome of BCT, which should be tailored during the treatment and follow-up process.Implications for PracticeCurrently, no literature exists concerning patients' needs for information regarding the cosmetic effects of breast-conserving therapy (BCT). Bringing up the cosmetic effects of BCT by health care professionals does not appear to be a standard part of treatment and follow-up. It is expected that the quality of care and life will be improved by providing information and guidance regarding the cosmetic outcome of BCT within the existing structure of the breast cancer pathway. Discussion and visualization of the cosmetic effects prior to treatment will lead to more realistic expectations, and as a result, secondary interventions, such as partial prostheses and plastic surgery, may be easier to discuss and accept.
Türkiye’de Okul Öncesi Eğitim Mekânlarına Yönelik Bilişsel Gelişimi Destekleyici Mobilya Önermeleri
Authors: SOYUPAK İlayda , ETİ PROTO Meltem 
Published: September 2018

Fiziksel çevre, okul öncesi eğitimde öğreticilik görevi üstlenir.
Çevreden gelen uyaranlar çocuk tarafından algılanır, işlenir, yorumlanır,
yeniden düzenlenir; böylelikle çocuk mekanı deneyimleyerek öğrenir. Öğreticilik
niteliği gözetildiğinde, okul öncesi eğitimde fiziksel çevre tasarımının
sürdürülen eğitim yaklaşımı ile doğrudan ilişkili olduğu ortaya çıkar. İyi
tasarlanmış bir okul öncesi eğitim çevresi, sürdürülen eğitim yaklaşımına bağlı
olarak çocuğa uygun öğrenme imkanları sunar ve çocuk gelişimini destekler. Okul
öncesi eğitim çevreleri farklı hacimsel özelliklere sahip olmasına karşın, ilgili
eğitim yaklaşımına uygun olarak tasarlanmış mobilyaların kullanılması ile o
eğitim yaklaşımının değerlerini yansıtan, öğretici, bilişsel gelişimi
destekleyici çevreler yaratılabilir. Bu çalışma kapsamında, Marmara
Üniversitesi Prof. Dr. Ayla Oktay Uygulama Anaokulunda gerçekleştirilen saha
araştırması ve ilişkili çalışmalardan elde edilen veriler değerlendirilerek
okul öncesi eğitimde bilişsel gelişimi destekleyici mobilya tasarım önerileri
geliştirilmiştir. Saha araştırmasında; seçilen okulun yetişkin ve çocuk
kullanıcılarıyla gerçekleştirilen sözlü görüşmeler, araştırmacının yetişkin ve
çocuk göz seviyesinde gerçekleştirdiği video kaydı, çocukların derslikleri tanıttığı
video kayıtları ve gözlem yöntemiyle veriler toplanmıştır. Tasarım sürecinde, konuyla ilgili bilgiler,
saha çalışmasından elde edilen veriler ışığında problem tanımlanarak, tasarım
önermeleri oluşturulmuştur. Bu çalışmada, okul öncesi eğitimde fiziksel çevre
ve bilişsel gelişim ilişkisi incelemesi ve saha çalışması sonucunda ortaya
çıkan, Milli Eğitim Bakanlığı eğitim yaklaşımına uygun olarak geliştirilen
mobilya tasarım çözümleri değerlendirilmiştir
OS JOVENS NA PÓS-MODERNIDADE: CALEIDOSCÓPIO DE SEUS PROJETOS DE VIDA
Authors: NASCIMENTO Ivany PINto , Rodrigues Sônia Eli 
Published: September 2018

RESUMO: Neste artigo, abordamos dois momentos. No primeiro, abordamos a modernidade e a pós-modernidade com o objetivo de situar a contemporaneidade e o chão onde essas juventudes se constroem. No segundo, enveredamos pela apresentação parcial da pesquisa sobre projetos de vida de jovens de escolas públicas da cidade de Belém. A pesquisa teve como amostra seis escolas distribuídas entre a região central e a periférica da cidade de Belém. Os sujeitos são 725 jovens distribuídos entre sexo feminino e o sexo masculino na faixa de 15 a 24 anos, dos 2º e 3º anos do Ensino Médio. Os resultados demonstram que as representações sociais refletem as imagens e os significados sobre o Projeto de Vida que transitam entre Educação, Trabalho e Vida Melhor. Além disso, a escola, sem ressignificar a racionalidade com a qual materializa o processo ensino-aprendizagem passa a representar um obstáculo por suas condições de ensino, pela ausência de projetos socioeducacionais que contribuam com a formação cidadã, a construção e a realização de projetos atuais e futuros de vida desses jovens. Em síntese, o descompasso entre os contextos sócio históricos nos quais as juventudes se constroem e a educação que recebem é preocupante, uma vez que fortalece o campo de vulnerabilidades, onde essas juventudes podem se inserir
O “CÍRCULO ANTROPOLÓGICO” E A SOCIOLOGIA DO IMAGINÁRIO: APROXIMAÇÕES ENTRE DURAND E MAFFESOLI
Authors: Barros Eduardo Portanova , Berghauser Francieli Costa 
Published: September 2018

Este artigo versa sobre aproximações possíveis entre a Teoria Geral do Imaginário de Gilbert Durand, principalmente no que diz respeito ao “círculo antropológico” (um reforço em relação ao “trajeto”), e sua relação com a Sociologia do Imaginário, sobretudo numa acepção compreensiva (derivada de Max Weber) em Michel Maffesoli. Para tanto, buscou-se uma tentativa de analogia entre as noções desses dois pensadores por meio das imagens simbólicas num e noutro. Procuramos compreender, de início, a questão do pertencimento de uma teoria em Merleau-Ponty. Seguimos com Durand e Maffesoli. Neste, o racionalismo de cunho moralista, inspirado que ele foi por Nietzsche. Depois, mas não de forma estanque, como se dá, ainda, a metodologia anarquista maffesoliana, que toma como alavanca metodológica o imaginário cotidiano. Já naquele (Durand), por sua vez, o imaginário é alógico, porque a existência humana, para ele, é antes poética do que sociológica. Conclusão: o aporte maffesoliano se baseia em uma fenomenologia do imaginário, mas não, como em Durand, numa Sociologia das Profundezas. A distinção, porém, nem sempre é excludente.
APRESENTAÇÃO
Authors: Rechia Schroeder Tânia Maria , Abreu Cláudia Barcelos Moura , Pesce Lucila 
Published: September 2018

Apresentação dossiê temático "Pós-modernidade e Educação: caleidoscópio de perspectivas" . Os artigos que compõem este dossiê apresentam estudos que provocam os leitores a pensar, justamente, sobre o atual tempo de impermanências e continuidades.
In vıtro Antioxidant Properties of Novel Compound (1R, 2R) -1,2-bis- (5- (4- Hydroxynaphthalen-1-ylazo) - [1,3,4] Thiadiazol-2-YL) -Ethane- 1,2-Diole
Authors: PARLAK Akif Evren , KOPARIR Pelin 
Published: September 2018

1,3,4-Thiadiazoles have a variety of biological
activities depending on their substituents. This study aims to investigate
the in vitro antioxidant properties of 1R,2R
-1,2-bis- (5- (4-hydroxynaphthalen-1-ylazo) - [1,3,4] thiadiazol-2-yl) -ethane- 1,2-diole novel
compound. In this study, antioxidant activities were measured by different methods
such as, DPPH. radical scavenging activity, iron reducing
power capacity, metal chelating activity and hydroxyl radical scavenging
activity. As a result, it was determined that this new compound has effective
antioxidant and free radical scavenging activity when compared to reference
antioxidants such as BHT and α-tocopherol.
New Composite, Poly(Hydroxyethylmethacrylate-Expanded Perlite), for Single step Separation of Egg White Lysozyme
Authors: AKKAYA Birnur , AKKAYA Recep 
Published: September 2018

In this study, we
investigated adsorption behaviour of lysozyme on poly(hydroxyethylmethacrylate-expanded
perlite) [P(Hema-Ep)]. For this purpose, we synthesized P(Hema-Ep) composite by
bulk polymerization and it was characterized by SEM, FTIR and swelling
ratio. The fresh chicken egg white
lysozyme was used as a model protein, had an isoelectric point (pI) 10.7 and
molecular weight (MW) 14 kDa. Adsorption
capacity was found 51 mg g-1 at room temperature and in 0.1 M pH=8.0 phosphate buffer.
Experiments on desorption and reusability were also performed. It
appears that P(Hema-Ep) composites can be
used ten times without lost of efficiency.
Lysozyme purification, without causing any denaturation, can be
performed from chicken egg white by using this new synthesized composite in a
single step.
Bebida Gelada à Base de Café e Tangerina Desenvolvimento e Avaliação Sensorial
Authors: Rosário Fernanda Menegon , Vendruscolo Thainara Amanda Duarte , Vieira Alexia Flávia França , Rodrigues Marjory Xavier 
Published: September 2018

Pesquisadores têm mostrado que os consumidores estão buscando produtos diferenciados, prontos para beber, produzidos à base de café. Assim, o objetivo deste trabalho foi elaborar uma bebida mista gelada de café e suco de tangerina e verificar sua aceitabilidade sensorial. Após testes preliminares, as formulações para análise sensorial foram determinadas; as formulações consistiam em 60% de café filtrado e 40% de suco de tangerina com variações nas concentrações de açúcar, 5%, 7,5% e 10%. Contagem de coliformes a 45 ºC e identificação de Salmonella sp. foram realizadas, sendo encontrados, respectivamente, <3,0 NMP/mL e ausência/25mL em todas as formulações. A análise sensorial foi realizada utilizando escala hedônica de nove pontos e escala de intenção de compra com cinco pontos, sessenta provadores não treinados avaliaram as bebidas apresentadas. Média, desvio-padrão, análise de variância (ANOVA) e teste de Tukey (p≤0,05) foram empregados para análise dos dados. Verificou-se que a formulação contendo 7,5% de açúcar adicionado foi a mais aceita entre os provadores, enquanto, a formulação com 10% apresentou médias inferiores às demais. Adicionalmente, foi estimada a composição da bebida, indicando o potencial nutritivo do produto ao combinar café e tangerina. Ressalta-se a boa aceitabilidade da bebida, embora café gelado não tenha tradição de consumo no país.Palavras-chave: Café. Suco de Fruta. Citrus reticulata. Novo Produto. AbstractResearchers have shown that consumers have been looking for differenced products, ready-to-drink, based coffee. Thus, the aim of this paper was to develop an iced coffee and tangerine juice beverage and to verify its sensory acceptance. After preliminary tests, the formulations to sensorial analysis were determined; the formulations consisted of 60% of filter coffee, 40% of tangerine juice with different concentration of sugar, 5%, 7.5%, and 10%. Enumeration of coliform bacteria at 45 ºC and Salmonella sp. identification were carried out, <3.0 MPN/mL and absence/25mL, respectively, were detected in all formulations. Sensory analysis was performed using hedonic scale of nine points and purchase intent scale of five points; sixty untrained tasters evaluated the presented beverages. Mean, standard error of the mean, variance analysis (ANOVA) and Tukey test (p≤0.05) were applied to data analysis. It was verified that the formulation containing 7.5% of sugar was the most accepted among tasters; meanwhile, the formulation with 10% of sugar had inferior mean compared to the others. Additionally, the beverage nutritional composition was estimated; it was indicated the nutritional potential of the product combining coffee and tangerine. It is highlighted the good acceptability of beverage although iced-coffee is not traditionally consumed in the country.Keywords: Coffee. Juice Fruit. Citrus reticulate. New Product.
Missing IUCD strings: an analysis
Authors: Verma Upasana , Gupta Mamta , Saini Vandana 
Published: September 2018

Background: Missing IUCD strings, i.e. IUCD strings that are not visible at the external cervical os, are a commonly encountered problem and needs to be analysed.Methods: IUCD users coming for routine checkup (follow-up / renewal / removal) or with any complaints related to IUCD or gynecological complaints or referred from other health center and found to be having missing threads were included in the study. Complaints by woman, obstetric history, details of IUCD insertion, USG imaging reports were recorded. Removal of IUCD was done if indicated or if the woman desired so, by simple OPD procedure and if required in operation theatre.Results: Out of 324 IUCD users who were examined in OPD, missing IUCD threads were found in 69. About half of them were asymptomatic. AUB was the commonest symptom. 82.6% women had IUCD in situ on USG. Displacement was seen in 10.14%, embedment in 4.35%. Expulsion was seen in 4.35% women. Removal was done in only 29 women. Removal was done by simple OPD procedure in 24 women, as minor OT procedure in 3. Only 1 required hysteroscopic removal. Commonest cause of missing threads was found to be broken, detached or severed strings.Conclusions: As most of these women with missed IUCD strings, IUCD was found to be in situ on ultrasound imaging; hence, these women need counselling regarding continuation of using IUCD. If required, removal can be done as an OPD procedure.
Study of prevalence of maternal anaemia and its fetal outcome at rural tertiary care centre
Authors: Verma Vandana , Vishwakarma Soniya , Chand Ramesh , Gupta Umesh Kumar 
Published: September 2018

Background: Anaemia is a major public health problem especially among low socioeconomic class of the population in developing countries. Prevalence of anaemia among pregnant women in developing countries is 51%. Anaemia is defined by the WHO as haemoglobin levels of less than 11 gm. % in pregnancy. The present study was aimed to find out prevalence of anaemia in rural tertiary care centre to see the foetal outcome in anaemic women.Methods: This is a retrospective observational study done in the Department of Obstetrics and Gynaecology, University of medical sciences Saifai, Etawah from June 2017 to November 2017. All the women admitted to labour room in third trimester and delivered here were included in the study excluding the patients with pre-eclampsia, eclampsia, gestational diabetes mellitus, heart disease, patients with other medical disorders and patients with twin pregnancy, antepartum haemorrhage and the patients who did not deliver here.Results: Prevalence of anaemia was 87.3 %. severe anaemia was found in 3.5 % women. The percentage of preterm births was more in anaemic women that is 16.9 %.Conclusions: Anaemia in pregnancy is a major public health problem in India. The number of IUGR and LBW babies were more in anaemic women. Anaemia is related to serious consequences in mother and baby if not diagnosed and treated timely. It can be prevented by increasing the awareness regarding need of iron intake during pregnancy.
Enhancing contraceptive usage by immediate postpartum intra uterine contraceptive device insertion with evaluation of safety, acceptability and expulsion
Authors: Tirupati Lekhya , Shivaraju Pradeep , Lingegowda Krishna , Srinivasan Sabitha 
Published: September 2018

Background: India’s population which crossed one billion in 2000 is projected to reach 1.53 billion by 2050 making India the most populous country in world. In India 65% of women have unmet need for family planning in the first post-partum year. PPIUCD is highly effective, safe, long-acting, coitus independent and rapidly reversible method of contraception with very few side effects. Since there is tenfold increase in institutional deliveries due to maternity benefit schemes, postpartum period is potentially an ideal time to begin contraception as women are more strongly motivated and these women would leave the hospital with contraceptive in place.Methods: The present study was a prospective study to assess the acceptance rate of PPIUCD insertion and evaluation of safety of Cu T 380A when inserted within ten minutes of placental expulsion in 100 women delivering at PESIMSR, Kuppam. A specially designed proforma was used to collect the data of women attending hospital between period June 2016 to June 2017.Results: Out of 486 patients who were counselled only 100 women (20.57%) accepted for PPIUCD insertion. The acceptance rate of PPIUCD is 20.57%. Of 100 women who had PPIUCD insertion, 91 were seen at follow up, 76 (78.12%) women were continuing with no complaints and only 15 (16.4%) women developed complications. PPIUCD was found to be safe as there was no reported case of perforation or failure during usage. The complications like expulsion was found to be 1.09%, infection 5.4%, pain abdomen 5.4%, bleeding 1.09% and missing strings 5.4%.Conclusions: PPIUCD was demonstrably safe, having no reported case of uterine perforation. Expulsion rates are low implying more retention rates, thus more effective. Public awareness regarding the concept and advantages of PPIUCD insertion can be improved by mass media approach and creating strategies and training programmes under Government policies.
A comparative study of efficacy of letrozole and clomiphene citrate for ovulation induction
Authors: Jain Shaveta , Dahiya Pushpa , Yadav Jyoti , Jain Nitin 
Published: September 2018

Background: This study was conducted to evaluate the efficacy of letrozole as an ovulation inducing agent and to compare it with clomiphene citrate (CC) in infertile women.Methods: This study includes 100 women referred to gynecology OPD of Pt. B.D Sharma, PGIMS, Rohtak with infertility due to dysovulation. The patients were divided in two groups each comprised of 50 patients, Alternate women were enrolled in study group (Letrozole). Ultrasonic follicular monitoring was done on day 10, 12, 14, 16 of menstrual cycle to measure the number, size of mature follicles. Endometrial thickness and trilaminar pattern of endometrium was compared in between the groups. Inj. Gonadotrophin (hCG) was given as a trigger intramuscularly when follicle size was between 18 to 21mm. After 36 hours of hCG administration ovulation was confirmed on ultrasound.Results: Mean age, parity, and the duration of infertility were similar in both groups. Ovulation rate was 81.6% in letrozole group and was higher than control group(p<.01). The average number of follicles in the control group was 1.90±0.77and 1.17±0.47 in the study group(p<.001). Endometrial thickness in the study group was 7.55±1.12mm and in the control group it was 6.06±0.87(p<.01). Pregnancy rate in study group was 48 % and control group 16%(p<.05).Conclusions: Aromatase inhibitors (Letrozole) is a new group of drugs to join the arsenal of infertility treatments. The result of this preliminary study suggests that letrozole is associated with higher ovulation rate, higher endometrial thickness and trilaminar pattern thus resulting in higher pregnancy rate. Clomiphene citrate may be replaced by letrozole as primary treatment for ovulation induction in infertile patients.