bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED ARTICLE: LncGPR107 drives the self-renewal of liver tumor initiating cells and liver tumorigenesis through GPR107-dependent manner
Authors: Huang Guanqun , Jiang Hui , Lin Ye , Xia Wuzheng , Luo Yuanwei , Wu Yanpeng , Cai Weilong , Zhou Xinke , Jiang Xianhan 
Published: June 2018

Abstract
Background
With self-renewal and differentiation properties, liver tumor initiating cells (TICs) are the reasons for tumor initiation, metastasis and drug resistance. G protein coupled receptors (GPCR) are critical modulators in many physiological and pathological processes. While, their roles in liver TICs are unknown.

Methods
An unbiased screening was performed using online-available data dataset. Liver TICs were sorted by FACS with surface marker CD133, or enriched by oncosphere formation. TIC self-renewal was examined by oncosphere formation and tumor initiation assay. Loss of function and gain of function assays were performed to examine the role of lncRNA. RNA pulldown, RNA immunoprecipitation, ChIP, western blot and double FISH were used explore the molecular mechanism of lncRNA.

Results
We performed an unbiased screening for GPCR expression in liver cancers, and found GPR107 was the most highly expressed GPCR in liver cancer and liver TICs. GPR107 was essential for the self-renewal of liver TICs. The expression of GPR107 was regulated by a long noncoding RNA lncGPR107. LncGPR107 was also highly expressed in liver cancers and liver TICs. LncGPR107 drove the self-renewal of liver TICs through GPR107. Moreover, lncGPR107 recruited SRCAP complex to GPR107 promoter to drive its transcriptional activation. LncGPR107 depletion inhibited the binding of SRCAP complex and GPR107 promoter and subsequent GPR107 expression. Moreover, LncGPR107-SRCAP-GPR107 can be targeted for liver TIC elimination.

Conclusion
GPR107 was the most highly expressed GPCR in liver cancer and liver TICs. LncGPR107 participated in the transcriptional regulation of GPR107 in cis, through recruiting SRCAP remodeling complex to GPR107 promoter. This work revealed the important role of GPCR signaling in liver TIC self-renewal and added a new layer for liver TIC and GPCR regulation.
The RASopathy Family: Consequences of Germline Activation of the RAS/MAPK Pathway
Authors: Tajan Mylène , Paccoud Romain , Branka Sophie , Edouard Thomas , Yart Armelle 
Published: June 2018

AbstractNoonan syndrome [NS; Mendelian Inheritance in Men (MIM) #163950] and related syndromes [Noonan syndrome with multiple lentigines (formerly called LEOPARD syndrome; MIM #151100), Noonan-like syndrome with loose anagen hair (MIM #607721), Costello syndrome (MIM #218040), cardio-facio-cutaneous syndrome (MIM #115150), type I neurofibromatosis (MIM #162200), and Legius syndrome (MIM #611431)] are a group of related genetic disorders associated with distinctive facial features, cardiopathies, growth and skeletal abnormalities, developmental delay/mental retardation, and tumor predisposition. NS was clinically described more than 50 years ago, and disease genes have been identified throughout the last 3 decades, providing a molecular basis to better understand their physiopathology and identify targets for therapeutic strategies. Most of these genes encode proteins belonging to or regulating the so-called RAS/MAPK signaling pathway, so these syndromes have been gathered under the name RASopathies. In this review, we provide a clinical overview of RASopathies and an update on their genetics. We then focus on the functional and pathophysiological effects of RASopathy-causing mutations and discuss therapeutic perspectives and future directions.
A Randomized Trial of Continuous Noninvasive Blood Pressure Monitoring During Noncardiac Surgery
Authors: Maheshwari Kamal , Khanna Sandeep , Bajracharya Gausan Ratna , Makarova Natalya , Riter Quinton , Raza Syed , Cywinski Jacek B. , Argalious Maged , Kurz Andrea , Sessler Daniel I. 
Published: June 2018

BACKGROUND:
Intraoperative hypotension is associated with postoperative mortality. Early detection of hypotension by continuous hemodynamic monitoring might prompt timely therapy, thereby reducing intraoperative hypotension. We tested the hypothesis that continuous noninvasive blood pressure monitoring reduces intraoperative hypotension.

METHODS:
Patients ≥45 years old with American Society of Anesthesiologists physical status III or IV having moderate-to-high-risk noncardiac surgery with general anesthesia were included. All participating patients had continuous noninvasive hemodynamic monitoring using a finger cuff (ClearSight, Edwards Lifesciences, Irvine, CA) and a standard oscillometric cuff. In half the patients, randomly assigned, clinicians were blinded to the continuous values, whereas the others (unblinded) had access to continuous blood pressure readings. Continuous pressures in both groups were used for analysis. Time-weighted average for mean arterial pressure <65 mm Hg was compared using 2-sample Wilcoxon rank-sum tests and Hodges Lehmann estimation of location shift with corresponding asymptotic 95% CI.

RESULTS:
Among 320 randomized patients, 316 were included in the intention-to-treat analysis. With 158 patients in each group, those assigned to continuous blood pressure monitoring had significantly lower time-weighted average mean arterial pressure <65 mm Hg, 0.05 [0.00, 0.22] mm Hg, versus intermittent blood pressure monitoring, 0.11 [0.00, 0.54] mm Hg (P = .039, significance criteria P < .048).

CONCLUSIONS:
Continuous noninvasive hemodynamic monitoring nearly halved the amount of intraoperative hypotension. Hypotension reduction with continuous monitoring, while statistically significant, is currently of uncertain clinical importance.
The Expression of Time (Spinoza, Deleuze, Cinema)
Authors: Casarino Cesare 
Published: June 2018

Abstract
This essay investigates the absent presence of Baruch Spinoza’s thought in Gilles Deleuze’s Cinema 1: The Movement-Image and Cinema 2: The Time-Image and argues that the concept of expression—as articulated by Deleuze in his study on Spinoza, Expressionism in Philosophy, as well as in his Logic of Sense—constitutes the crucial condition of possibility of Deleuze’s philosophical theory of the cinema and, in particular, of his twofold understanding of cinema as medium of expression and of cinema as expression of time.
Read Yourself!
Authors: Biddick Kathleen 
Published: June 2018

AbstractCentered on the opening scene of reading staged by Giorgio Agamben in his study of reading machines, The Open: Man and Animal, this article considers how Agamben’s own messianic reading of an illuminated page from a medieval Ashkenazi Bible (Biblioteca Ambrosiana MSS B 30–32) erases the entangled biopolitical histories of medieval Ashkenazi Jews and their Christian sovereigns. What happens if we read the distinctive animal-headed Jews peopling medieval Ashkenazi manuscripts of Bibles and Haggadot dated to the thirteenth and early fourteenth centuries, not in a messianic mode but in the temporal mode of biopolitical bare life? What is the temporal structure of precarious life? Furthermore, how does this Ashkenazi figural tradition of animal-headed Jews point to forms of resistance to the biopolitics of medieval Christendom? How is messianic theory now unconsciously entangled in modes of temporality of precarious life, then?
Face Value (the Prosopa of Money)
Authors: Szendy Peter 
Published: June 2018

Abstract
“Face value,” according to the OED, is “the value printed or depicted on a coin, banknote, ticket, etc., especially when less than the actual value.” But we could hear in this expression an imperative—“face value!”—an injunction to consider value face to face, that is, prosopon pros prosopon. Prosopon, the Greek word for mask, gave rise to the rhetorical figure of prosopopoeia (prosopon poiein: to confer a mask or a face). A striking occurrence of prosopopoeia is found in the eighteenth-century British genre called “it-narrative,” in which inanimate things speak and recount their life narrative. The first of these novels—Charles Gildon’s Golden Spy (1702)—gives voice to a bunch of coins. And the genre becomes self-reflexive when money starts to “coin words,” like the autobiographical protagonist of The Adventures of a Bank-Note (1770). Drawing on ancient sources, contemporary art, and readings of Nietzsche, Marx, and Levinas, the article attempts to formulate the following question: Why does money need a mask?
Climate Trauma, or the Affects of the Catastrophe to Come
Authors: Richardson Michael 
Published: June 2018

AbstractThe climate catastrophe to come is traumatically affecting, whether in its micro and macro manifestations, in the threat it poses to existing ways of life, in its upending of entrenched understandings of the workings of the world, or in the injury it is doing to particular lives and wider ecologies. It works on ecologies and bodies alike as a kind of wounding, one not simply or solely to the everyday stuff of biological life but to the very constitution of experience and expression. Critiquing and extending writing on climate, trauma, and aesthetic experience by E. Ann Kaplan (2016), Timothy Morton (2013), and others, this article argues that these affects of climate catastrophe are traumatically affecting without necessarily being traumatizing: they are jarring, rupturing, disjunctive experiences of future crisis in the now. This article traces these affects of apocalypse as they circulate traumatically in three texts: George Miller’s film Mad Max: Fury Road (2015), Marina Zurkow’s animation Slurb (2009), and Briohny Doyle’s novel The Island Will Sink (2016). Climate catastrophe, that most threatening yet elusive of hyperobjects, marks and emerges irresistibly from within these works, not simply as theme, setting, or symbol but as the form of their affectivity. This intensity presses into the present from the future, shaping how the catastrophe to come is felt today and exposing crucial tensions between aesthetic expression and lived experience.
Octopamine signaling in the metazoan pathogen S
chistosoma mansoni: localization, small-molecule screening and opportunities for drug development
Authors: El-Sakkary Nelly , Chen Steven , Arkin Michelle R. , Caffrey Conor R. , Ribeiro Paula 
Published: June 2018

ABSTRACT
Schistosomiasis is a tropical disease caused by a flatworm trematode parasite that infects over 200 million people worldwide. Treatment and control of the disease rely on just one drug, praziquantel. The possibility of drug resistance coupled with praziquantel's variable efficacy encourages the identification of new drugs and drug targets. Disruption of neuromuscular homeostasis in parasitic worms is a validated strategy for drug development. In schistosomes, however, much remains to be understood about the organization of the nervous system, its component neurotransmitters and potential for drug discovery. Using synapsin as a neuronal marker, we map the central and peripheral nervous systems in the Schistosoma mansoni adult and schistosomulum (post-infective larva). We discover the widespread presence of octopamine (OA), a tyrosine-derived and invertebrate-specific neurotransmitter involved in neuromuscular coordination. OA labeling facilitated the discovery of two pairs of ganglia in the brain of the adult schistosome, rather than the one pair thus far reported for this and other trematodes. In quantitative phenotypic assays, OA and the structurally related tyrosine-derived phenolamine and catecholamine neurotransmitters differentially modulated schistosomulum motility and length. Similarly, from a screen of 28 drug agonists and antagonists of tyrosine-derivative signaling, certain drugs that act on OA and dopamine receptors induced robust and sometimes complex concentration-dependent effects on schistosome motility and length; in some cases, these effects occurred at concentrations achievable in vivo. The present data advance our knowledge of the organization of the nervous system in this globally important pathogen and identify a number of drugs that interfere with tyrosine-derivative signaling, one or more of which might provide the basis for a new chemotherapeutic approach to treat schistosomiasis.
This article has an associated First Person interview with the first author of the paper.
Clinical application of high frequency jet ventilation in stereotactic liver ablations – a methodological study
Authors: Galmén Karolina , Freedman Jacob , Toporek Grzegorz , Goździk Waldemar , Harbut Piotr 
Published: June 2018

Background: Computer-assisted navigation during thermal ablation of liver tumours, may help to correct needle placement and improve ablation efficacy in percutaneous, laparoscopic and open interventions. The potential advantage of using high frequency jet-ventilation technique (HFJV) during the procedure is by minimising the amplitude of respiration-related upper-abdominal organs movements. The aim of this clinical methodological trial was to establish whether HFJV would give less ventilatory induced liver movements than conventional ventilation, during stereotactic navigated ablation of liver metastases under open surgery. Methods: Five consecutive patients scheduled for elective, open liver ablation under general propofol and remifentanil anaesthesia were included in the study protocol. During the stereotactic targeting of the tumours, HFJV was chosen for intraoperative lung ventilation. For tracking of liver movement, a rigid marker shield was placed on the liver surface and tracked with an optical position measurement system. A 4D position of the marker shield was measured for HFJV and conventional tidal volume lung ventilation (TV). At each time point the magnitude of liver displacement was calculated as an Euclidean distance between translational component of the marker shield's 3D position and previously estimated centroid of the translational motion. Results: The mean Euclidean liver displacement was 0.80 (0.10) mm for HFJV and 2,90 (1.03) mm for TV with maximum displacement going as far as 12 mm on standard ventilation (p=0.0001). Conclusion: HFJV is a valuable lung ventilation method for patients undergoing stereotactic surgical procedures in general anaesthesia when reduction of organ displacement is crucial.
Water Supply Rates for Recirculating Evaporative Cooling Systems
Authors: Purswell Joseph L. , Linhoss John E. , Edge Carson M. , Davis Jeremiah D. , Campbell Jesse C. 
Published: June 2018

Abstract. Evaporative cooling (EC) is an important tool to reduce heat stress in animal housing systems. Expansion of ventilation capacity in tunnel ventilated poultry facilities has resulted in increased water demand for EC systems. As water resources become more limited and costly, proper planning and design of water supply systems is critical to ensure demand is met during periods of heat stress which increase EC use and bird water consumption. Few estimates of EC water use in animal housing applications are available in the literature and available estimates are geographically limited or rely on extreme weather events. The goal of this analysis was to provide guidance for EC water supply design to accommodate estimates of peak demand, rather than average consumption rates. Keywords: Ventilation, Broiler house, Water conservation, Housing design.
Preanalytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for “Precision Medicine and Pharmacometabolomics Task Group”—The Metabolomics Society Initiative)
Authors: Kirwan Jennifer A , Brennan Lorraine , Broadhurst David , Fiehn Oliver , Cascante Marta , Dunn Warwick B , Schmidt Michael A , Velagapudi Vidya 
Published: June 2018

AbstractBACKGROUNDThe metabolome of any given biological system contains a diverse range of low molecular weight molecules (metabolites), whose abundances can be affected by the timing and method of sample collection, storage, and handling. Thus, it is necessary to consider the requirements for preanalytical processes and biobanking in metabolomics research. Poor practice can create bias and have deleterious effects on the robustness and reproducibility of acquired data.CONTENTThis review presents both current practice and latest evidence on preanalytical processes and biobanking of samples intended for metabolomics measurement of common biofluids and tissues. It highlights areas requiring more validation and research and provides some evidence-based guidelines on best practices.SUMMARYAlthough many researchers and biobanking personnel are familiar with the necessity of standardizing sample collection procedures at the axiomatic level (e.g., fasting status, time of day, “time to freezer,” sample volume), other less obvious factors can also negatively affect the validity of a study, such as vial size, material and batch, centrifuge speeds, storage temperature, time and conditions, and even environmental changes in the collection room. Any biobank or research study should establish and follow a well-defined and validated protocol for the collection of samples for metabolomics research. This protocol should be fully documented in any resulting study and should involve all stakeholders in its design. The use of samples that have been collected using standardized and validated protocols is a prerequisite to enable robust biological interpretation unhindered by unnecessary preanalytical factors that may complicate data analysis and interpretation.
Involvement of mitophagy in cisplatin-induced cell death regulation
Authors: Abdrakhmanov Alibek , Kulikov Andrey V. , Luchkina Ekaterina A. , Zhivotovsky Boris , Gogvadze Vladimir 
Published: June 2018

Abstract
Mitophagy, the selective degradation of mitochondria via the autophagic pathway, is a vital mechanism of mitochondrial quality control in cells. The removal of malfunctioning or damaged mitochondria is essential for normal cellular physiology and tissue development. Stimulation of mitochondrial permeabilization and release of proapoptotic factors from the intermembrane space is an essential step in triggering the mitochondrial pathway of cell death. In this study, we analyzed the extent to which mitophagy interferes with cell death, attenuating the efficiency of cancer therapy. We show that stimulation of mitophagy suppressed cisplatin-induced apoptosis, while mitophagy inhibition stimulates apoptosis and autophagy. Suppression of mitophagy involved production of reactive oxygen species, and the fate of cell was dependent on the interplay between endoplasmic reticulum stress and autophagy.
IL-37 affects the occurrence and development of endometriosis by regulating the biological behavior of endometrial stromal cells through multiple signaling pathways
Authors: Jiang Jianfa , Yu Kenan , Jiang Zhaoying , Xue Min 
Published: June 2018

Abstract
Endometriosis (EMs) is a chronic inflammatory condition. Interleukin (IL)-37 is a member of the IL-1 family and an anti-inflammatory cytokine. This study aimed to evaluate the possible role of IL-37 in the EMs pathogenesis. We investigated the in vivo effect of IL-37 on EMs by injection with recombinant human IL-37 (rhIL-37) into EMs mice. Furthermore, we evaluated the in vitro effects of IL-37 on proliferation, adhesion, migration and invasiveness of endometrial stromal cells (ESCs), and explored whether Wnt/β-catenin and mitogen-activated protein kinase (MAPK) pathways were involved in this process. In cultured ESCs, IL-37 overexpression significantly suppressed both protein and mRNA expression of the inflammation-associated cytokines, including IL-1β, IL-6, IL-10 and tumor necrosis factor (TNF-α). Furthermore, IL-37 overexpression significantly inhibited ESCs proliferation, adhesion, migration, invasion and the activity of matrix metalloproteinase (MMP)-2 and MMP-9. In contrast, knockdown of IL-37 exerted the opposite effects. Importantly, the IL-37-mediated action in ESCs was through inactivation of Wnt/β-catenin, p38 MAPK, extracellular signal-related kinases MAPK and c-Jun N-terminal kinase MAPK pathways. Moreover, EMs mice treated with rhIL-37 showed the decreased endometriotic-like lesion size and lesion weight, lower expression of IL-1β, IL-6, IL-10, TNF-α, vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-I (ICAM-I) and MMP-2/9 activity in peritoneal fluid compared with the wide type (WT) EMs mice. These findings suggest that IL-37 suppresses cell proliferation, adhesion, migration and invasion of human ESCs through multiple signaling pathways, thereby affecting the occurrence and development of EMs.
A Genetic Algorithm Approach for Group Recommender System Based on Partial Rankings
Authors: Meena Ritu , Bharadwaj Kamal K. 
Published: June 2018

Abstract
Many recommender systems frequently make suggestions for group consumable items to the individual users. There has been much work done in group recommender systems (GRSs) with full ranking, but partial ranking (PR) where items are partially ranked still remains a challenge. The ultimate objective of this work is to propose rank aggregation technique for effectively handling the PR problem. Additionally, in real applications, most of the studies have focused on PR without ties (PRWOT). However, the rankings may have ties where some items are placed in the same position, but where some items are partially ranked to be aggregated may not be permutations. In this work, in order to handle problem of PR in GRS for PRWOT and PR with ties (PRWT), we propose a novel approach to GRS based on genetic algorithm (GA) where for PRWOT Spearman foot rule distance and for PRWT Kendall tau distance with bucket order are used as fitness functions. Experimental results are presented that clearly demonstrate that our proposed GRS based on GA for PRWOT (GRS-GA-PRWOT) and PRWT (GRS-GA-PRWT) outperforms well-known baseline GRS techniques.
Buoyancy-Driven Rayleigh–Taylor Instability in a Vertical Channel
Authors: Aljahdaly Noufe H. , Hadji Layachi 
Published: June 2018

Abstract
Suppose that a vertical tube is composed of two chambers that are separated by a retractable thermally insulated thin membrane. The upper and lower chambers are filled with an incompressible fluid and maintained at temperatures

T

c

{T_{c}}

and

T

h

>

T

c

{T_{h}}>{T_{c}}

, respectively. Upon removal of the membrane, the two fluid masses form an unstably stratified Rayleigh–Taylor-type configuration with cold and heavy fluid overlying a warmer and lighter fluid and separated by an interface across which there is a discontinuity in the density. Due to the presence of an initial discontinuity between two homogeneous states, this problem is mathematically homologous to that of the shock tube problem with the thermal expansion playing the role of pressure. When the two fluid regions are brought directly into contact with each other and the transient interfacial fluctuations have subsided, we show the emergence of a stationary state of convection through a supercritical bifurcation provided a threshold value for the temperature difference is exceeded. We suggest a possible way for the experimental testing of the theoretical results put forth in this paper.