bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of MIF, Beclin1, and LC3 in human salivary gland adenoid cystic carcinoma and its prognostic value
Authors: Li Chenxi , Chen Qingli , Tian Zhongqi , Li Shixiao , Gong Zhongcheng , Lin Zhaoquan , Wang Bing , Liu Hui 
Published: May 2019

Abstract
Adenoid cystic carcinoma (ACC) is an uncommon salivary gland malignancy with a poor long-term prognosis. Clinical reports show the high rates of local recurrences and distant metastases. This study aimed to investigate the expression of MIF, Beclin1, and light-chain 3 (LC3) in salivary adenoid cystic carcinoma (SACC).
Tissue specimens were obtained from 48 salivary glands adenoid cystic carcinoma (SACC) patients and 15 oral squamous cell carcinoma (OSCC) patients. Immunohistochemical staining was performed to estimate the level of LC3, Beclin1, and MIF. All SACC patients were followed up. The Kaplan–Meier method was used to compare the prognosis of patients after treatment.
The 3-year, 5 year-, and 10 year-survival rates of the SACC patients were 83.9%, 69.9%, and 46.6%, respectively. MIF, LC3, and Beclin1 in SACC were all obviously over-expressed. MIF showed an increased tendency in cases with advanced TNM stages, and at the same time, there was an inversely proportional relationship between MIF and LC3, Beclin1.
The long-term survival of SACC patients is poor. MIF might be a risk factor for SACC patients, whereas, LC3 and Beclin1 might be an effective strategy for treatment of SACC.
Single shot versus continuous technique adductor canal block for analgesia following total knee arthroplasty
Authors: Zhang Lu-kai , Zhang Bo-ya , Quan Ren-fu , Xu Hong , Sun Yu-jie , Zhou Jian-hong 
Published: May 2019

AbstractBackground:An adductor canal block (ACB) provides recognized analgesia following total knee arthroplasty (TKA). This meta-analysis compared the single-injection ACB (SACB) with the continuous-injection ACB (CACB).Method:Relevant studies were searched from PubMed (1996–October 2018), Embase (1980–October 2018), and Cochrane Library (CENTRAL, October 2018). Four randomized controlled trials (RCTs), which compared SACB with CACB, were included in our meta-analysis.Results:Four RCTs met the inclusion criteria. Our pooled data indicated that the SACB group had similar efficacy compared with the CACB group in terms of morphine consumption (P = .19), time to first opioid request (P = .32), range of motion (P = .97), and visual analogue scale (VAS) scores at 24 hours at rest (P = .12) and movement (P = .24), without increasing the risk of complications (P = .97) and length of stay (P = .54).Conclusion:The SACB technique provides similar analgesia in the 24 hours following TKA compared with CACB, while the CACB method was better over 48 hours.
Dose-response relationship between higher serum calcium level and higher prevalence of hyperuricemia
Authors: Liu Zhichen , Ding Xiang , Wu Jing , He Hongyi , Wu Ziying , Xie Dongxing , Yang Zidan , Wang Yilun , Tian Jian 
Published: May 2019

AbstractThe aim of the study was to examine the relationship between serum calcium (Ca) levels and the prevalence of hyperuricemia (HU).The data included in this analysis were extracted from a population-based study conducted at the Xiangya Hospital Health Management Centre. Serum Ca levels were measured using the Arsenazo III method. HU was defined as the uric acid ≥416 μmol/L for male subjects, and ≥360 μmol/L for female subjects. The association between serum Ca levels and the prevalence of HU was evaluated using logistic and spline regression.The present study included a total of 6337 subjects. The overall prevalence of HU for the target population was 17.5%. Compared with the lowest quintile, the odds ratios adjusted by age, sex, body mass index, smoking, and drinking for HU were 1.51 [95% confidence interval (CI): 1.20–1.91], 1.43 (95% CI: 1.13–1.82), 2.02 (95% CI: 1.61–2.54), and 2.54 (95% CI: 2.02–3.18) for the second, third, fourth, and fifth quintiles of serum Ca levels, respectively (Pfor trend <.001), and a positive dose-response relationship was observed. Similar results were observed for men and women, respectively. The findings were not materially altered by the adjustment for further potential confounders.Subjects with higher serum Ca levels are subject to a higher prevalence of HU in a dose-response relationship manner.
Bone transport with a unilateral external fixator for femoral infected nonunion after intramedullary nailing fixation
Authors: Liu Chunfeng , Zhang Xianghong , Zhang Xiangsheng , Li Zhihong , Xu Yaozeng , Liu Tang 
Published: May 2019

Abstract
This is a therapeutic study to evaluate the results of femoral infected nonunion using bone transport with an external fixator after debridement and irrigation. We retrospectively reviewed 15 patients with femoral infected nonunion after intramedullary nailing fixation of fractures from October 1999 to January 2010 in our institute. There were 7 males and 8 females with an average age of 32.5 years. First, the infection was eradicated completely, and the medullary canals were continuous irrigated for 2-3 weeks. After eradicating the infection tissues, the mean amount of bone defect was 8.7 cm (range, 4.0–16.0 cm). The unilateral consecutive distraction-compression osteosynthesis technique was applied after long-time medullary cavity-wound exclusion surgery. Enumeration data was described by frequency and measurement data by mean. Bone infections were controlled in all patients except 1 patient after the first debridement and irrigation. All patients have achieved bony union without recurrence of infection during the follow-up period, the mean external fixation index was 43.4 day/cm. According to the criteria recommended by Paley, the bone results were graded as excellent in 13 (86.7%) cases and good in 2 (13.3%) cases; the functional results were graded as excellent in 6 (40.0%) cases, good in 6 (40.0%) cases and fair in 3 (20.0%) cases. In management of femoral infectious nonunion which caused by intramedullary nailing fixation, the surgery of consecutive compression-distraction osteogenesis with unilateral external fixator achieves a highly effective treatment, and the method of debridement and irrigation is a compatible choice on the phase of infection-elimination.
Efficacy and safety of direct-acting antiviral therapy for chronic hepatitis C genotype 6
Authors: Luo Aoran , Xu Pan , Wang Jin , Li Zuli , Wang Shunli , Jiang Xiaoyan , Ren Hong , Luo Qiang 
Published: May 2019

Abstract

Background:
Because of the heterogeneity of hepatitis C virus (HCV) distribution of different genotypes, large-scale clinical trials on direct-acting antiviral (DAA) mainly included patients with genotype 1 and genotype 3 infection. Data on the efficacy of direct-acting antiviral agents in patients with chronic genotype 6 HCV infection are limited.

Methods:
The PubMed, Embase, and the Cochrane Libraries were searched comprehensively. All published clinical trials assessing the efficacy of DAA therapy for patients with chronic genotype 6 HCV infection were included. Sustained virological response (SVR) and rapid virological response (RVR) were pooled. Additional meta-analyses were also performed to compare the efficacy of DAA therapy in HCV-6 versus HCV-1 or HCV-3 patients.

Results:
Seventeen studies met the inclusion criteria and were included in our meta-analysis. The pooled SVR of all single arms was 95% [95% confidence interval (CI): 0.90–0.97]. The pooled RVR of all single arms was 97% (95% CI: 0.95–0.99). The SVR and RVR were both similar between HCV-6 and HCV-1 or HCV-3. Adverse events were common but rarely caused treatment interruption.

Conclusion:
Based on the available data, our results indicate that DAA treatment is effective and safe for patients with genotype 6 HCV infection, and the efficacy was similar compared to patients with genotype 1 HCV or genotype 3 HCV infection.
The association between adherence and dementia in chronic obstructive pulmonary disease
Authors: Liao Kuang-Ming , Chen Chung-Yu 
Published: May 2019

Abstract
Our previous studies have shown that patients with chronic obstructive pulmonary disease (COPD) have an increased risk of dementia and that COPD combined with dementia confers an increased risk of acute respiratory dysfunction, severe sepsis, and hospital mortality. The aim of this study was to investigate whether medication adherence can decrease the risk of dementia in COPD.
This retrospective study enrolled COPD patients from 1 million beneficiaries randomly sampled from all beneficiaries in Taiwan. We excluded COPD patients not prescribed a bronchodilator or those using theophylline or short-acting β2-agonists for <1 year. To ensure a sufficient observation period, we excluded patients diagnosed with dementia within 1 year after the diagnosis of COPD or those prescribed bronchodilators after the diagnosis of dementia. Patients with COPD and a history of severe mental disorders were also excluded.
There was a total of 13,015 first diagnoses of COPD from 1998 to 2012, of whom 9,489 had a proportion of days covered (PDC) <80% and 1,206 had a PDC ≥80% before matching. In the high PDC group, 226 (18.74%) patients had acute exacerbations of COPD and were hospitalized within 1 year after diagnosis. Compared with the PDC <80% group, the PDC ≥80% group had a risk of dementia with an adjusted hazard ration of 0.88, but there were no statistically significant differences (95% confidence interval, 0.57–1.35).
Medication adherence to bronchodilators may not modify the risk of dementia in patients with COPD.
Corneal cross-linking for keratoconus caused by compulsive eye rubbing in patients with Tourette syndrome
Authors: Shinzawa Megumi , Kato Naoko , Kasai Kozue , Konomi Kenji , Chai Yuzhu , Shimazaki Jun 
Published: May 2019

Abstract

Rationale:
Eye rubbing is an important risk factor for keratoconus progression. Tourette syndrome (TS) is a neurological disorder, and approximately 50% of individuals with TS exhibit obsessive-compulsive behaviors including eye rubbing. We report the effects of corneal cross-linking (CXL) on the progression of keratoconus combined with psychiatric treatment for 3 patients with TS.

Patients’ concerns:
Three cases, 24-year-old male, 14-year-old male, and 17-year-old male, were all referred to our institute, due to decreased visual acuity.

Diagnosis:
All 3 patients were diagnosed with progressive keratoconus. They were found to rub their eyes, and were also diagnosed with TS by psychiatrists.

Intervention:
Upon diagnosis of keratoconus, we performed CXL on 1 eye of each patient.

Outcomes:
After CXL, there was no further progression. Psychiatric medication was also required.

Lessons:
For patients with keratoconus caused by eye rubbing due to TS, CXL seems to be effective when done in association with psychiatric treatment.
Recovery of paraplegia following postoperative epidural hematomas in lumbar canal stenosis surgery by closed kinetic chain (CKC) exercises
Authors: Komatsu Jun , Sato Keita , Iwabuchi Masumi , Fukuda Hironari , Kusano Keigo , Kaneko Kazuo , Shirado Osamu 
Published: May 2019

Abstract

Rationale:
A postoperative spinal epidural hematoma (PSEH) is among the most devastating complications following spine and spinal cord surgery, and it should be considered before performing microendoscopic decompression as part of minimally invasive surgery, since early recovery is one of the advantages of this procedure.

Patient concerns:
A 70-year-old woman with lumbar spinal stenosis at L4-5 underwent tubular surgery with the assistance of endoscopic laminectomy (MEL), but 2 days after the surgery, the patient noticed decreased lower limb sensation and power of the right leg, and she developed numbness from the level of L5 and weakness from the L4, 5 myotome distally.

Diagnoses:
An epidural hematoma at the L4-5 surgical site was found on magnetic resonance imaging of the lumbar spine and evacuated operatively. This rare complication appears to be the result of a PSEH. In the present case, complete neurological recovery was not achieved, despite rapid surgery.

Interventions:
The patient's course and physical therapy, which focused on attitude maintenance practice and muscle-strengthening exercise of the closed kinetic change (CKC) type from the early stage of paraplegia, were specifically examined.

Outcomes:
The patient recovered complete motor function with attitude maintenance practice and muscle strengthening exercises after 3 months. CKC exercise in particular may contribute to improving caudal muscle weakness, including the L4, 5 innervated area (e.g., tibialis anterior [TA], extensor hallucis longus [EHL], flexor hallucis longus [FHL], gastrocnemius [GC], etc.).

Lessons:
Prevention of PSEH is needed to not only avoid neurological deterioration, but also avoid delaying the patient's recovery. CKC exercise may contribute to improving the prolonged paralysis associated with a PSEH. Future studies should involve larger numbers of patients to evaluate the clinical features of PSEH and treatment by rehabilitation with more effective muscle exercises and stretches.
Hypertensive disorders during pregnancy and elevated blood pressure in the offspring
Authors: Yu Huan , He Yuan , Mao Zhengxia , Dong Wenbing , Fu Xiaodong , Lei Xiaoping 
Published: May 2019

Abstract

Background:
Hypertensive disorders during pregnancy (HDP), including gestational hypertension, preeclampsia (PE), and chronic hypertension, affect approximately 10% of pregnancies worldwide. PE was associated with elevated blood pressure (BP) in the offspring confirmed by previous literature. No previous systematic review has investigated the associations between the subtypes of HDP and BP in offspring. Therefore, from the published literature, the present systematic review and meta-analysis aims to reach to a clear consensus on this topic.

Methods:
The Cochrane Handbook for Systematic Reviews of Interventions was used to structure our methodological approach, and the Preferred Reporting Items for Systematic Reviews and Meta Analyses Protocols guidelines to this protocol. We will include cohort, case-control, and cross-sectional studies, in which HDP or its subtypes were reported and BP in the offspring was the outcome of interest. A systematic search of PubMed, Embase, the Cochrane library, and Web of Science will be conducted according to a specific search strategy. The titles and abstracts of all literature will be reviewed independently by 2 authors. A standardized data collection form will be used for data extraction. The overall pooled estimates will be calculated by meta-analysis in Revman 5.3 based on an inverse variance method. According to the heterogeneity by the I
2, a random-effect model or a fixed-effect model will be chosen to pool data. Risk of bias and quality of the studies will be assessed by a suitable bias classification tool.

Results:
This study will provide high-quality evidence of the effects in offspring BP, which were influenced by different subtypes of HDP.

Conclusion:
This systematic review will infer a conclusion on the associations between different subtypes of HDP and BP in offspring.

Ethics and dissemination:
Due to the data come from the published study, the present systematic review and meta-analysis does not require ethics approval. Findings will be published in a peer-reviewed journal.

Registration:
Supporting data can be found at the International Prospective Register of Systematic Reviews (PROSPERO) website, with registration number CRD 42018110872.
Efficacy of low-dose rivaroxaban in an 88-year-old female with pulmonary embolism
Authors: Zhou Huanyu , Wei Qi , Wu Haidi , Tang Minglong , Yang Shuo , Liu Yang , Qin Ling 
Published: May 2019

Abstract

Rationale:
Rivaroxaban has numerous advantages over traditional anticoagulation therapy. Fixed doses can be administered without requiring routine monitoring of coagulation, and anticoagulation efficacy is more predictable. Safety, including fewer drug interactions, and reduced bleeding, is also improved with rivaroxaban based on current recommendations. The goal of this report was to explore if low-dose rivaroxaban 10 mg once daily was effective in an elderly patient who developed minor bleeding when treated with rivaroxaban (10 mg twice daily) for a pulmonary embolism.

Patient concerns:
We present an 88-year-old female with dyspnea and fatigue, which became increasingly worse over a month in the absence of medication. Her weight was 64 kg. Routine coagulation assays and renal function were normal at time of admission.

Diagnosis:
Deep vein thrombosis and pulmonary embolism were confirmed by venous compression ultrasonography and computed tomography pulmonary angiography.

Interventions:
Oral rivaroxaban 10 mg twice daily was administered, but the patient developed hemoptysis and gum bleeding 5 days later. The dose of rivaroxaban was reduced to 10 mg once daily, and bleeding gradually disappeared after 3 days.

Outcome:
At follow-up 90 days after treatment, the patient reported no discomfort. Venous compression ultrasonography and computed tomography pulmonary angiography showed normal results; therefore, treatment was terminated.

Lessons:
Elderly patients exhibit variable tolerance of anticoagulants, warranting careful consideration of the risk of bleeding. Low-dose rivaroxaban was an effective treatment for pulmonary embolism in the elderly patient presented here.
Percutaneous vertebroplasty with granulated allogeneic bone grafting using screw-view model of navigation for thoracolumbar compressive fracture
Authors: Zhao Jianwu , Zhao Xin , Yang Lili , Qu Yang , Dong Rongpeng , Kang Mingyang , Zhang Xiwen , Zheng Changjun , Yu Tong 
Published: May 2019

Abstract

Rationale:
The aim of this study was to assess the accuracy of percutaneous puncture needle with screw view model of navigation (SVMN) and the effect of periacetabular vertebroplasty (PVP) with granulated allogeneic bone grafting in thoracolumbar compressive fracture (TCF).

Patient concerns:
A 46-year-old female patient associated with high fall injury showed symptoms characterized by back pain and restricted movement of the right lower extremity.

Diagnoses:
The patient was diagnosed with a TCF, right femoral neck fracture, and lumbar vertebrae hyperosteogeny.

Interventions:
A SVMN was used to guide our puncture needle insertion; and PVP was performed with granulated allogeneic bone grafting in this patient.

Outcomes:
The follow-up lasted for 29 months. It took 2.4 minutes to design the trajectory of puncture needle, 2.1 minutes to implant the puncture needle, and 6.3 minutes to undergone fluoroscopy. Postoperative visual analog scale and Oswestry disability index scores were improved obviously compared with those before the operation. The Cobb angle of fractured vertebrae improved from 9.3° to 7.3° after treatment. The height ratio of fractured vertebrae increased from 79.5% to 90.6% postoperatively. Intraoperative blood loss amounted to 11 ml. No clinical complications were observed, including neurovascular injury and new fracture of adjacent vertebra.

Lessons:
Puncture needle placement under the guidance of SVMN is verified as a convenient, safe and reliable method, and PVP with granulated allogeneic bone grafting can effectively restore the height of anterior fractured vertebra, filling the gaps in the fractured vertebrae, and reconstructing the completeness of the fractured vertebrae.
Information experiences, needs, and preferences of colonoscopy patients
Authors: Lee Eugene , Shafer Leigh Anne , Walker John R. , Waldman Celeste , Michaud Valerie , Yang Chengyue , Bernstein Charles N. , Hathout Linda , Park Jason , Sisler Jeff , Wittmeier Kristy , Restall Gayle , Singh Harminder 
Published: May 2019

Abstract
Better pre-colonoscopy education may lead to improved bowel preparation, decreased anxiety, and a willingness to go direct-to-colonoscopy. We assessed information experiences, needs, and preferences of patients undergoing colonoscopy.
A self-administered survey was distributed between 08/2015 and 06/2016 to patients in Winnipeg, Canada when they attended an outpatient colonoscopy. The amount, type, helpfulness, and satisfaction with information provided were analyzed. Linear and logistic regression analyses were used to assess predictors of satisfaction with various aspects of the information received, as well as overall satisfaction with the provided information.
Although the majority of the 1580 respondents were satisfied with the information they received, only 68% of respondents coming for a repeat colonoscopy and 59% of those coming for first colonoscopy perceived receiving just the right amount of information from their endoscopy doctor. One quarter or less of the respondents indicated they received just the right amount of information from any source other than their colonoscopy doctor. 38% coming for a first colonoscopy and 44% coming for a repeat colonoscopy indicated they received no information from their family physician. Those coming for their first colonoscopy had a lower average score (9.7 vs 11.1; P < .001) for amount of information received (scale 0-15), were less satisfied with the information they received (P = .005) and found the information to be less clear (P = .004).
Many patients going for colonoscopy in a large urban practice are inadequately informed about the various aspects of the procedure and it is worse for those going for first rather than repeat colonoscopy.
Non–English Language Availability of Community Health Center Websites
Authors: Rodriguez Jorge A. , Davis Roger B. , Percac-Lima Sanja 
Published: May 2019

Background:
For limited English-proficient (LEP) patients, the digital divide has narrowed, creating a new population of Internet users. However, language-appropriate health information is difficult to find. Community health center (CHC) websites are health information resources and their homepages are critical access points for patients. CHCs supported by Health Resources and Services Administration (HRSA) care for many LEP patients.

Objective:
We sought to determine the number of HRSA-supported CHC websites providing translated homepage content.

Research Design:
In February 2017, we performed a cross-sectional analysis of the language availability of CHC homepages.

Measures:
The primary outcome was availability of translated content on CHC homepages. Secondary outcomes were method of translation and associations between homepage translation and CHC demographics, including percent LEP population and socioeconomic and Internet access characteristics.

Results:
Of the 1400 CHC homepages, 480 (34.3%) provided translated information with half using Google Translate. We found higher odds of having a translated homepage as the LEP population by county increased [odds ratio (OR): 1.26, confidence interval (CI): 1.07–1.49, P=0.005], Internet subscription at the state level increased (OR: 1.19, CI: 1.02–1.38, P=0.026), and if health centers were in metropolitan areas (OR: 1.81, CI: 1.31–2.51, P<0.001). There was also higher likelihood of having a homepage translated to Spanish in counties with higher Spanish LEP populations (OR: 1.39, CI: 1.19–1.63, P<0.001), but this did not extend to non-Spanish languages (OR: 0.85, CI: 0.71–1.04, P=0.131).

Conclusions:
Despite increased Internet use among LEP patients and linguistic diversity of the CHC populations, there is a lack of language-appropriate content on CHC website homepages.