bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of occludin protein mobility with paracellular leak pathway permeability in renal epithelia
Authors: Axis Josephine , Kolb Alexander L. , Bacallao Robert L. , Amsler Kurt 
Published: October 2018

ABSTRACTStudies have demonstrated regulation of the epithelial paracellular permeability barrier, the tight junction, by a variety of stimuli. Recent studies have reported a correlation between changes in paracellular permeability, particularly paracellular permeability to large solutes (leak pathway), and mobility of the tight junction protein, occludin, in the plane of the plasma membrane. This had led to the hypothesis that changes in occludin protein mobility are causative for changes in paracellular permeability. Using a renal epithelial cell model system, MDCK, we examined the effect of various manipulations on both leak pathway permeability, monitored as the paracellular movement of a fluorescent molecule (calcein), and occludin protein mobility, monitored through fluorescence recovery after photobleaching. Our results indicate that knockdown of the associated tight junction protein, ZO-1, increases baseline leak pathway permeability, whereas, knockdown of the related tight junction protein, ZO-2, does not alter baseline leak pathway permeability. Knockdown of either ZO-1 or ZO-2 decreases the rate of movement of occludin protein but only knockdown of ZO-2 protein alters the percent of occludin protein that is mobile. Further, treatment with hydrogen peroxide increases leak pathway permeability in wild type MDCK cells and in ZO-2 knockdown MDCK cells but not in ZO-1 knockdown MDCK cells. This treatment decreases the rate of occludin movement in all three cell lines but only alters the mobile fraction of occludin protein in ZO-1 knockdown MDCK cells. Finally, we examined the effect of renal ischemia/reperfusion injury on occludin protein mobility in vivo.Ischemia/reperfusion injury both increased the rate of occludin mobility and increased the fraction of occludin protein that is mobile. These results indicate that, at least in our cell culture and in vivo model systems, there is no consistent correlation between paracellular leak pathway permeability and occludin protein mobility.
Absence of general rules governing molluscan body-size response to climatic fluctuation during Cenozoic
Authors: Chattopadhyay Debarati , Chattopadhyay Devapriya 
Published: October 2018

AbstractBody size is a key factor in dictating the fate of interaction between an organism and its surrounding environment. A negative temperature-size relationship (TSR) has been suggested as one of the universal responses to climatic warming. It is also predicted that groups with narrow latitudinal range, tropical affinity and higher body size, would show higher sensitivity to climatic fluctuation. Moreover, because of the difference in thermal sensitivity, it is also expected that the response to climatic fluctuation would be different between epifaunal and infaunal groups. To confirm the generality of these relationship among marine families, we compiled the relationship between body-size and global temperature trends over Cenozoic using a database of marine benthic molluscs of class gastropoda and bivalvia resolved to temporal stages. We evaluated the dependence of climate induced body-size response to the existing size and latitudinal spread via correlating the first-difference correlation coefficient of temperature-size (ρ1st(size-temp)) with maximum size and latitudinal spread of family respectively. Cenozoic record of this highly diverse group does not show any signature of TSR for molluscan class or for any other regional, ecological groups during the past 66My long climatic fluctuation. We did not find any evidence supporting heightened response to climatic fluctuation in groups with limited latitudinal spread or with large body-size. The tropical species did not show significant difference in their body-size response in comparison to temperate species. It also shows lack of any difference in response between ecological groups of molluscs with varying substrate relationship and hence, refutes the predicted variation due to difference in thermal specialization. Although a negative correlation between maximum latitudinal spread and ρ1st(size-temp)is observed for infaunal families, it is not statistically significant. Our results highlight the limited validity of “universal rules” in explaining the climate induced morphological response of marine communities in deep time and underscores the complexity in generalizing the biotic outcome of future climatic fluctuation.
Estimation of auditory steady-state responses based on the averaging of independent EEG epochs
Authors: Prado-Gutierrez Pavel , Martínez-Montes Eduardo , Weinstein Alejandro , Zañartu Matías 
Published: October 2018

AbstractThe amplitude of the auditory steady-state responses (ASSRs) generated in the brainstem exponentially decreases over the averaging of subsequent EEG epochs. This behavior is partially due to the adaptation of the auditory response to the continuous and monotonous stimulation. We analyzed the potential clinical relevance of the ASSR adaptation. Specifically, we compare the ASSR amplitude computed in two conditions: (1) when the auditory responses -embedded in the EEG epochs that are averaged in the estimation procedure- are influenced by the previous stimulation; and (2) when they are independent of the previous stimulation. ASSR were elicited in eight anesthetized adult rats by 8-kHz tones, modulated in amplitude at 115 Hz. ASSR amplitudes were computed using three averaging methods (standard, weighted and sorted averaging). We evaluated the ASSR amplitude as a function of sub-set of epochs selected for the averaging and the improvement in the ASSR detection resulting from averaging independent epochs. Due to adaptation, the ASSR amplitude computed by averaging dependent EEG epochs relied upon the averaging method. Lower ASSR amplitudes were obtained as EEG segments containing unadapted responses were systematically excluded from the averaging. In the absence of EEG artifacts, the ASSR amplitudes did not depend on the averaging method when they were computed from independent EEG epochs. The amplitude of independent ASSRs were up to 35% higher than those obtained by processing dependent EEG segments. Extracting the ASSR amplitude from independent epochs halved the number of EEG segments needed to be averaged to achieve the maximum detection rate of the response. Acquisition paradigm based on a discrete acoustic stimulation (in which segments of AM-sounds of several seconds in length are presented after a given inter stimulus interval), in combination with appropriated averaging methods might increase the accuracy of audiological tests based on ASSRs.
Inhibition of platelet function by targeting the platelet cytoskeleton via the LIMK-signaling pathway
Authors: Antonipillai Juliana , Rigby Sheena , Bassler Nicole , Peter Karlheinz , Bernard Ora 
Published: October 2018

AbstractActin is highly abundant in platelets, and platelet function is dependent on actin structures. Actin filaments are dynamic structures involved in many cellular processes including platelet shape changes and adhesion. The actin cytoskeleton is tightly regulated by actin-binding proteins, which include the members of the actin depolymerising factor (ADF)/cofilin family. LIM kinase (LIMK) and slingshot phosphatase (SSH-1L) regulate actin dynamics by controlling the binding affinity of ADF/cofilin towards actin. We hypothesised that inhibition of LIMK activity may prevent the changes in platelet shape during their activation and therefore their function by controlling the dynamics of Factin. Therefore, inhibition of LIMK activity may represent an attractive new strategy to control and inhibit platelet function; particularly the formation of stable platelet aggregates and thus stable thrombi.
Thermal acclimation of photosynthetic activity and Rubisco content in two hybrid poplar clones
Authors: Benomar Lahcen , Moutaoufik Mohamed. Taha , Elferjani Raed , Isabel Nathalie , DesRochers Annie , Guellab Ahmed El , Khlifa Rim , Idrissi Hassania Lala Amina 
Published: October 2018

AbstractThe mechanistic bases of thermal acclimation of net photosynthetic rate (An) are still difficult to discern and empirical research remains limited, particularly for hybrid poplar. In the present study, we examined the contribution of a number of biochemical and biophysical traits on thermal acclimation ofAnfor two hybrid poplar clones. We grew cuttings ofPopulus maximowiczii×Populus nigra(M×N) andPopulus maximowiczii×Populus balsamifera(M×B) clones under two day/night temperature of 23°C/18°C and 33°C /27°C and under low and high soil nitrogen level. After 10 weeks, we measured leaf RuBisCO and RuBisCO activase (RCA) amounts and the temperature response ofAn, dark respiration (Rd), stomatal conductance, (gs), maximum carboxylation rate of CO2(Vcmax) and photosynthetic electron transport rate (J). Results showed that a 10°C increase in growth temperature resulted in a shift in thermal optimum (Topt) ofAnof 6.2±1.6 °C and 8.0±1.2 °C for clone M×B and M×N respectively, and an increasedAnandgsat the growth temperature for clone M×B but not M×N. RuBisCO amount was increased by N level but was insensitive to growth temperature whileRCAamount and the ratio of its short to long isoform was stimulated by warm condition for clone M×N and at low N for clone M×B. The activation energy ofVcmaxandJdecreased under warm condition for clone M×B and remain unchanged for clone M×N. Our study demonstrated the involvement of bothRCA, activation energy ofVcmaxand stomatal conductance in thermal acclimation ofAn.
Description of Cranial Elements and Ontogenetic Change within Tropidolaemus wagleri (Serpentes: Crotalinae)
Authors: Hill Nicolette 
Published: October 2018

AbstractTropidolaemus wagleri is a species of Asian pitviper with a geographic range including Thailand, Vietnam, Malaysia, Singapore, Bruniei, parts of Indonesia, and the Philippines. Tropidolaemus is a member of the Crotalinae subfamily, within Viperidae. The genus Tropidolaemus includes five species, and was once included within the genus Trimeresurus. While some osteologic characteristics have been noted a comprehensive description of cranial elements has not been produced for T. wagleri. An in-depth description of the cranial skeleton of Tropidolaemus wagleri lays the foundation for future projects to compare and contrast other taxa within Crotalinae and Viperidae. The chosen reference specimen was compared to the presumed younger specimens to note any variation in ontogeny. The study here provides a comprehensive description of isolated cranial elements as well as a description of ontogenetic change within the specimens observed. This study contributes to the knowledge of osteological characters in T. wagleri and provides a foundation for a long term project to identify isolated elements in the fossil record.
The mitochondrial copper chaperone COX11 plays an auxiliary role in the defence against oxidative stress
Authors: Radin Ivan , Gey Uta , Kost Luise , Steinebrunner Iris , Rödel Gerhard 
Published: October 2018

AbstractCOX11, a protein anchored in the inner mitochondrial membrane, was originally identified as a copper chaperone delivering Cu+ to the cytochrome c oxidase of the respiratory chain. Here, we present evidence that this protein is also involved in the defence against reactive oxygen species. Quantitative PCR analyses in the model plant Arabidopsis thaliana revealed that the level of AtCOX11 mRNA rises under oxidative stress. The unexpected result that AtCOX11 knock-down lines contained less ROS than the wild-type can possibly be explained by the impaired oxidative phosphorylation, resulting in less respiration-dependent ROS formation. Similarly, we observed that yeast Saccharomyces cerevisiae ScCOX11 null mutants produced less ROS than wild-type cells. However, when exposed to oxidative stress, yeast strains overexpressing ScCOX11 or AtCOX11 showed lower ROS levels compared with the control indicating a ROS-detoxifying effect of the COX11 proteins. The additive effect on ROS sensitivity upon deletion of ScCOX11 in addition to the known ROS scavenger gene SOD1 encoding superoxide dismutase 1 corroborates the oxidative stress-relieving function of ScCOX11. Moreover, yeast strains overexpressing soluble versions of either AtCOX11 or ScCOX11 became more resistant against oxidative stress. The importance of three conserved cysteines for the ROS scavenger function became apparent after their deletion that resulted in the loss of ROS resistance. Further studies of strains producing COX11 proteins with individually mutated cysteines indicate that the formation of disulphide bridges might be the underlying mechanism responsible for the antioxidative activity of COX11 proteins. Both AtCOX11 and ScCOX11 apparently partake in oxidative stress defence by directly or indirectly exploiting the redox capacity of their cysteine residues.
Co-designed of network scheduling and sliding mode control for underwater shuttle based on adaptive genetic algorithm
Authors: Li Zeyu , Liu Weidong , Li Le , Liu Zhi , Zhang Feihu 
Published: October 2018

Purpose
Underwater shuttle is widely used in scenarios of deep sea transportation and observation. As messages are transmitted via the limited network, high transmission time-delay often leads to information congestion, worse control performance and even system crash. Moreover, due to the nonlinear issues with respect to shuttle’s heading motion, the delayed transmission also brings extra challenges. Hence, this paper aims to propose a co-designed method, for the purpose of network scheduling and motion controlling.

Design/methodology/approach
First, the message transmission scheduling is modeled as an optimization problem via adaptive genetic algorithm. The initial transmission time and the genetic operators are jointly encoded and adjusted to balance the payload in network. Then, the heading dynamic model is compensated for the delayed transmission, in which the parameters are unknown. Therefore, the adaptive sliding mode controller is designed to online estimate the parameters, for enhancing control precision and anti-interference ability. Finally, the method is evaluated by simulation.

Findings
The messages in network are well scheduled and the time delay is thus reduced, which increases the quality of service in network. The unknown parameters are estimated online, and the quality of control is enhanced. The control performance of the shuttle control system is thus increased.

Originality/value
The paper is the first to apply co-design method of message scheduling and attitude controlling for the underwater unmanned vehicle, which enhaces the control performance of the network control system.
Philosophy of language and accounting
Authors: Alexander David , de Brébisson Hélène , Circa Cristina , Eberhartinger Eva , Fasiello Roberta , Grottke Markus , Krasodomska Joanna 
Published: October 2018

PurposeAccounting practices vary not only across firms, but also across countries, reflecting the respective legal and cultural background. Attempts at harmonization therefore continue to be rebuffed. The purpose of this paper is to argue that different wordings in national laws, and different interpretations of similar wordings in national laws, can be explained by taking recourse to the philosophy of language, referring particularly to Searle and Wittgenstein.Design/methodology/approachThe example of the substance over form principle, investigated in seven countries, is particularly suitable for this analysis. It is known in all accounting jurisdictions, but still has very different roots in different European countries, with European and international influences conflicting, which is reflected in the different wording of the principle from one country to the next, and the different socially constructed realities associated with those wordings.FindingsThis paper shows that, beyond accounting practices, the legal and cultural background of a country affects the wording of national law itself. The broad conclusion is that different socially constructed realities might tend to resist any attempt at harmonized socially constructed words.Originality/valueThe paper contributes to the debate surrounding the possible homogenization of accounting regulations, illustrating the theory of the social construction of both “reality” and “language” on the specific application of one common principle to various Member State environments.
Suppression of nonlinear aeroelastic vibrations by learned neural network controller
Authors: Dul Franciszek 
Published: October 2018

PurposeThe purpose of the paper is to analyze the active suppression of the aeroelastic vibrations of ailerons with strongly nonlinear characteristics by neural network/reinforcement learning (NN/RL) control method and comparing it with the classic robust methods of suppression.Design/methodology/approachThe flexible wing and aileron with hysteresis nonlinearity is treated as a plant-controller system and NN/RL and robust controller are used to suppress the nonlinear aeroelastic vibrations of aileron. The simulation approach is used for analyzing the efficiency of both types of methods in suppressing of such vibrations.FindingsThe analysis shows that the NN/RL controller is able to suppress the nonlinear vibrations of aileron much better than linear robust method, although its efficiency depends essentially on the NN topology as well as on the RL strategy.Research limitations/implicationsOnly numerical analysis was carried out; thus, the proposed solution is of theoretical value, and its application to the real suppression of aeroelastic vibrations requires further research.Practical implicationsThe work shows the NN/RL method has a great potential in improving suppression of highly nonlinear aeroelastic vibrations, opposed to the classical robust methods that probably reach their limits in this area.Originality/valueThe work raises the questions of controllability of the highly nonlinear aeroelastic systems by means of classical robust and NN/RL methods of control.
Bending and vibration analysis of skew sandwich plate
Authors: Katariya Pankaj V. , Panda Subrata Kumar , Mahapatra Trupti Ranjan 
Published: October 2018

Purpose
The purpose of this paper is to develop a general mathematical model for the evaluation of the bending and vibration responses of the skew sandwich composite plate using higher-order shear deformation theory. The sandwich structural components are highly preferable in modern engineering application because of their desirable structural advantages despite the manufacturing and analysis complexities. The present model is developed to solve the bending and vibration problem of the skew sandwich composite plate with adequate accuracy numerically in the absence of the experimental analysis.

Design/methodology/approach
The skew sandwich composite plate structure is modelled in the present analysis by considering laminated face sheet in conjunction with isotropic and/or orthotropic core numerically with the help of the higher-order mathematical model. Further, the responses are computed numerically with the help of in-house computer code developed in matrix laboratory (MATLAB) environment in conjunction with finite element (FE) steps. The system governing equations are derived via variational technique for the computation of the static and the frequency responses.

Findings
The skew sandwich composite plate is investigated using the higher-order kinematic model where the transverse displacement through the thickness is considered to be linear. The convergence and the validation study of the bending and the frequency values of the sandwich structure indicate the necessary accuracy. Further, the current model has been used to highlight the applicability of the higher-order kinematics for the evaluation of the sandwich structural responses (frequency and static deflections) for different design parameters.

Originality/value
In the present paper, the bending and the vibration responses of the skew sandwich composite plate are analysed numerically using the equivalent single-layer higher-order kinematic theory for the isotropic and the orthotropic core numerically with the help of isoparametric FE steps. Finally, it is understood that the present model is capable of solving the sandwich structural responses with less computation cost and adequate accuracy.
An empirical study of biological scientists’ article sharing through ResearchGate
Authors: Kim Youngseek 
Published: October 2018

PurposeThe purpose of this paper is to investigate how attitudinal, normative and control beliefs influence scientists’ article sharing through ResearchGate.Design/methodology/approachA survey method was employed to examine a research model of scientists’ article sharing through ResearchGate. A total of 264 survey responses from biological scientists in the USA were used to evaluate the research model by using partial least square based structural equation modeling.FindingsThe results showed that scientists’ attitudinal beliefs (i.e. perceived relationship, reputation and risk), normative beliefs (i.e. subjective norm, perceived academic culture and community norm of article sharing) and control belief (i.e. perceived ease of use) all significantly affect their attitudes toward article sharing and article sharing intentions through ResearchGate.Research limitations/implicationsThe theory of planned behavior (TPB) was used to develop the research model, and the specific research constructs from prior literature were incorporated in the model. The TPB and related research constructs nicely explained biological scientists’ article sharing through ResearchGate.Practical implicationsThis study suggests that academic libraries can better promote their scientists’ article sharing through digital platforms such as institutional repositories as well as scholarly social media. This can be achieved by emphasizing its benefits, including potential relationships or collaborations, positive academic reputation and community norms of article sharing, and by decreasing scientists’ concerns about copyright infringements and effort expectancy involved in article sharing.Originality/valueAs one of the initial studies in scientists’ article sharing through ResearchGate, this study provides a holistic picture of how attitudinal, normative and control beliefs all affect scientists’ article sharing through ResearchGate.