bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of congenital heart surgery on quality of life in children and adolescents with surgically corrected Ventricular Septal Defect, Tetralogy of Fallot, and Transposition of the Great Arteries
Authors: Holst Line M. , Kronborg Jonas B. , Idorn Lars , Bjerre Jesper V. , Vejlstrup Niels , Juul Klaus , Ravn Hanne B. 
Published: July 2019

AbstractObjective:To describe the impact of CHD surgery in early childhood on quality of life in children aged 10–16 years with surgically corrected Ventricular Septal Defect, Transposition of the Great Arteries, and Tetralogy of Fallot.Method:A cross-sectional survey study of quality of life survey on 161 children and adolescents aged 10–16 years with surgically corrected Ventricular Septal Defect, Transposition of the Great Arteries, and Tetralogy of Fallot. The international Paediatric Quality of Life 4.0 quality of life questionnaires were applied and collected for assessment from patients and parents. The endpoints were total, physical, emotional, social, and school quality of life scores.Results:The quality of life total and school scores was significantly lower in children with CHD than their healthy peers. There was no significant difference in quality of life between the three CHD groups. All three CHD groups had a significantly lower total (7.7–13.2%, p<0.001) and school scores (21.1–31.6%, p<0.001) than the control group. The tetralogy of Fallot group was the only group that had significantly lower scores in the physical subscale (p<0.001) than the controls.Conclusion:Children and adolescents with surgically corrected CHD show losses in quality of life in total and school scores compared to healthy controls. The tetralogy of Fallot group was the only CHD group that had significantly lower physical score than the controls.
Reducing coercion in mental healthcare
Authors: Sashidharan S. P. , Mezzina Roberto , Puras Dainius 
Published: July 2019

AbstractAimsTo examine the extent and nature of coercive practices in mental healthcare and to consider the ethical, human rights challenges facing the current clinical practices in this area. We consider the epidemiology of coercion in mental health and appraise the efficacy of attempts to reduce coercion and make specific recommendations for making mental healthcare less coercive and more consensual.MethodsWe identified references through searches of MEDLINE, EMBASE, PsycINFO and CINAHL Plus. Search was limited to articles published from January 1980 to May 2018. Searches were carried out using the terms mental health (admission or detain* or detention or coercion) and treatment (forcible or involuntary or seclusion or restraint). Articles published during this period were further identified through searches in the authors' personal files and Google Scholar. Articles resulting from searches and relevant references cited in those articles were reviewed. Articles and reviews of non-psychiatric population, children under 16 years, and those pertaining exclusively to people with dementia were excluded.ResultsCoercion in its various guises is embedded in mental healthcare. There is very little research in this area and the absence of systematic and routinely collected data is a major barrier to research as well as understanding the nature of coercion and attempts to address this problem. Examples of good practice in this area are limited and there is hardly any evidence pertaining to the generalisability or sustainability of individual programmes. Based on the review, we make specific recommendations to reduce coercive care. Our contention is that this will require more than legislative tinkering and will necessitate a fundamental change in the culture of psychiatry. In particular, we must ensure that clinical practice never compromises people's human rights. It is ethically, clinically and legally necessary to address the problem of coercion and make mental healthcare more consensual.ConclusionAll forms of coercive practices are inconsistent with human rights-based mental healthcare. This is global challenge that requires urgent action.
Effect of the Quasi‐Biennial Oscillation on Carbon Monoxide in the Stratosphere
Authors: Yung Yuk L. , Long Junyang , Jiang Jonathan H. , Fan Siteng , Jiang Xun , Shia Run‐Lie 
Published: July 2019

AbstractThe interannual variability of tropical carbon monoxide from the Microwave Limb Sounder over 2004–2018 period is dominated by the quasi‐biennial oscillation (QBO). We simulate the carbon monoxide variability over this period using the 2‐D Caltech/JPL chemistry‐transport model. The chemistry‐transport model includes the photochemical sources and sinks and transport driven by a stream function and eddy diffusivity derived from the assimilated winds of National Centers for Environmental Prediction Reanalysis 2. The results show good agreement between model and Microwave Limb Sounder observations. We also investigate the anomalous period 2015–2016, when the QBO winds deviated significantly from their climatological values. The model simulations could capture the QBO features in agreement with observations for the anomalous period.
Coastal Semidiurnal Internal Tidal Incoherence in the Santa Maria Basin, California: Observations and Model Simulations
Authors: Kumar Nirnimesh , Suanda Sutara H. , Colosi John A. , Haas Kevin , Di Lorenzo Emanuele , Miller Arthur J. , Edwards Christopher A. 
Published: July 2019

AbstractA series of five realistic, nested, hydrostatic numerical ocean model simulations are used to study semidiurnal internal tide generation and propagation from the continental slope, through the shelf break and to the midshelf adjacent to Point Sal, CA. The statistics of modeled temperature and horizontal velocity fluctuations are compared to midshelf observations (30‐ to 50‐m water depth). Time‐ and frequency‐domain methods are used to decompose internal tides into components that are coherent and incoherent with the barotropic tide, and the incoherence fraction is 0.5–0.7 at the midshelf locations in both the realistic model and observations. In contrast, the incoherence fraction is at the most 0.45 for a simulation with idealized stratification, and neither atmospheric forcing nor mesoscale currents. Negligible conversion from barotropic to baroclinic energy occurs at the local shelf break. Instead, the dominant internal tide energy sources are regions of small‐scale near‐critical to supercritical bathymetry on the Santa Lucia escarpment (1,000–3,000 m), 70–80 km from the continental shelf. Near the generation region, semidiurnal baroclinic energy is primarily coherent and rapidly decays adjacent to the shelf break. In the realistically forced model, incoherent energy is less than 10% in the generation region, with a steady increase in incoherence fraction from the continental slope to the midshelf. Backward ray tracing from the midshelf to the Santa Lucia escarpment identifies multiple energy pathways potentially leading to spatial interference. As internal tides shoal on the predominantly subcritical slope/shelf system, temporally variable stratification and Doppler shifting from mesoscale and submesoscale features appear equally important in leading to the loss of coherence.
Time‐Lag Correlation Between Passive Microwave Measurements and Surface Precipitation and Its Impact on Precipitation Retrieval Evaluation
Authors: You Yalei , Meng Huan , Dong Jun , Rudlosky Scott 
Published: July 2019

AbstractThis study investigates the correlation between the upwelling microwave brightness temperature measured by satellite radiometer and surface precipitation rate from ground radar observations at different time lags. Results show that brightness temperatures correlate more strongly with the lagged surface precipitation rate than the simultaneous surface precipitation rate. The lag time for snowfall ranges from 30 to 60 min. This time lag effect has an important influence when evaluating the satellite retrieval results relative to ground observations. For example, the falsely identified pixels can decrease by as much as 23.88% when considering a 30‐min lag time. Furthermore, the satellite‐retrieved snowfall rate shows much stronger correlation with the time‐lagged surface snowfall rate than the simultaneous snowfall rate in cold environments and for tall storms. This work implies that the time of the level‐2 swath‐retrieved snowfall rate needs to shift forward when incorporated into the level‐3 gridded products.
Interseismic and Postseismic Shallow Creep of the North Qaidam Thrust Faults Detected with a Multitemporal InSAR Analysis
Authors: Daout Simon , Sudhaus Henriette , Kausch Thore , Steinberg Andreas , Dini Benedetta 
Published: July 2019

AbstractUnderstanding the mechanisms by which earthquake cycles produce folding and accommodate shortening is essential to quantify the seismic potential of active faults and integrate aseismic slip within our understanding of the physical mechanisms of the long‐term deformation. However, measuring such small deformation signals in mountainous areas is challenging with current space‐geodesy techniques, due to the low rates of motion relative to the amplitude of the noise. Here we successfully carry out a multitemporal Interferometric Synthetic Aperture Radar analysis over the North Qaidam fold‐thrust system in NE Tibet, where eight Mw> 5.2 earthquakes occurred between 2003 and 2009. We report various cases of aseismic slip uplifting the thickened crust at short wavelengths. We provide a rare example of a steep, shallow, 13‐km‐long and 6‐km‐wide afterslip signal that coincides spatially with an anticline and that continues into 2011 in response to a Mw 6.3 event in 2003. We suggest that a buried seismic slip during the 2003 earthquake has triggered both plastic an‐elastic folding and aseismic slip on the shallow thrusts. We produce a first‐order two‐dimensional model of the postseismic surface displacements due to the 2003 earthquake and highlight a segmented slip on three fault patches that steepen approaching the surface. This study emphasizes the fundamental role of shallow aseismic slip in the long‐term and permanent deformation of thrusts and folds and the potential of Interferometric Synthetic Aperture Radar for detecting and characterizing the spatiotemporal behavior of aseismic slip over large mountainous regions.
The effects of exercise session timing on weight loss and components of energy balance: midwest exercise trial 2
Authors: Willis Erik A. , Creasy Seth A. , Honas Jeffery J. , Melanson Edward L. , Donnelly Joseph E. 
Published: July 2019

Abstract
Background/objectives
Circadian physiology has been linked to body weight regulation and obesity. To date, few studies have assessed the association between exercise timing and weight related outcomes. The aim of this secondary analysis was to explore the impact of exercise timing (i.e., 24 h clock time of exercise session) on weight loss and components of energy balance.

Subjects/methods
Overweight/obese (BMI 25.0–39.9 kg/m2), physically inactive, young adults (~51% female) completed a 10-month supervised exercise program (400 or 600 kcal/session for 5 days/week) or served as non-exercise controls (CON). Participants were categorized based on the time of day in which they completed exercise sessions (Early-Ex: >50% of sessions completed between 7:00 and 11:59 am; (n = 21), Late-Ex: >50% of sessions completed between 3:00 and 7:00 pm; (n = 25), Sporadic-Ex: <50% of sessions completed in any time category; (n = 24), and CON; (n = 18)). Body weight, energy intake (EI; digital photography), and non-exercise physical activity (NEPA; accelerometer) were assessed at baseline, 3.5, 7, and 10 months. Total daily energy expenditure (TDEE; doubly labeled water), was assessed at baseline and 10 months.

Results
At month 10, weight loss was significantly greater in both Early-EX (−7.2 ± 1.2%; p < 0.001) and Sporadic-EX (− 5.5 ± 1.2%; p = 0.01) vs CON (+0.5 ± 1.0%), and Early-EX vs Late-EX (−2.1 ± 1.0%; p < 0.001). There were no between group differences for change in TDEE, EI, and non-exercise energy expenditure (P > 0.05). A significant group × time interaction (p = 0.02) was observed for NEPA (counts/min), however, after adjusting for multiple comparisons, group effects were no longer significant.

Conclusions
Despite minimal differences in components of energy balance, Early-EX lost significantly more weight compared with Late-Ex. Although the mechanisms are unclear, the timing of exercise may be important for body weight regulation.
Microbe-driven chemical ecology: past, present and future
Authors: Schmidt Ruth , Ulanova Dana , Wick Lukas Y , Bode Helge B , Garbeva Paolina 
Published: July 2019

Abstract
In recent years, research in the field of Microbial Ecology has revealed the tremendous diversity and complexity of microbial communities across different ecosystems. Microbes play a major role in ecosystem functioning and contribute to the health and fitness of higher organisms. Scientists are now facing many technological and methodological challenges in analyzing these complex natural microbial communities. The advances in analytical and omics techniques have shown that microbial communities are largely shaped by chemical interaction networks mediated by specialized (water-soluble and volatile) metabolites. However, studies concerning microbial chemical interactions need to consider biotic and abiotic factors on multidimensional levels, which require the development of new tools and approaches mimicking natural microbial habitats. In this review, we describe environmental factors affecting the production and transport of specialized metabolites. We evaluate their ecological functions and discuss approaches to address future challenges in microbial chemical ecology (MCE). We aim to emphasize that future developments in the field of MCE will need to include holistic studies involving organisms at all levels and to consider mechanisms underlying the interactions between viruses, micro-, and macro-organisms in their natural environments.
Simultaneous production of fresh water and electricity via multistage solar photovoltaic membrane distillation
Authors: Wang Wenbin , Shi Yusuf , Zhang Chenlin , Hong Seunghyun , Shi Le , Chang Jian , Li Renyuan , Jin Yong , Ong Chisiang , Zhuo Sifei , Wang Peng 
Published: July 2019

AbstractThe energy shortage and clean water scarcity are two key challenges for global sustainable development. Near half of the total global water withdrawals is consumed by power generation plants while water desalination consumes lots of electricity. Here, we demonstrate a photovoltaics-membrane distillation (PV-MD) device that can stably produce clean water (>1.64 kg·m−2·h−1) from seawater while simultaneously having uncompromised electricity generation performance (>11%) under one Sun irradiation. Its high clean water production rate is realized by constructing multi stage membrane distillation (MSMD) device at the backside of the solar cell to recycle the latent heat of water vapor condensation in each distillation stage. This composite device can significantly reduce capital investment costs by sharing the same land and the same mounting system and thus represents a potential possibility to transform an electricity power plant from otherwise a water consumer to a fresh water producer.
Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex
Authors: Faria Joana , Glover Lucy , Hutchinson Sebastian , Boehm Cordula , Field Mark C. , Horn David 
Published: July 2019

AbstractThe largest gene families in eukaryotes are subject to allelic exclusion, but mechanisms underpinning single allele selection and inheritance remain unclear. Here, we describe a protein complex sustaining variant surface glycoprotein (VSG) allelic exclusion and antigenic variation in Trypanosoma brucei parasites. The VSG-exclusion-1 (VEX1) protein binds both telomeric VSG-associated chromatin and VEX2, an ortholog of nonsense-mediated-decay helicase, UPF1. VEX1 and VEX2 assemble in an RNA polymerase-I transcription-dependent manner and sustain the active, subtelomeric VSG-associated transcription compartment. VSG transcripts and VSG coats become highly heterogeneous when VEX proteins are depleted. Further, the DNA replication-associated chromatin assembly factor, CAF-1, binds to and specifically maintains VEX1 compartmentalisation following DNA replication. Thus, the VEX-complex controls VSG-exclusion, while CAF-1 sustains VEX-complex inheritance in association with the active-VSG. Notably, the VEX2-orthologue and CAF-1 in mammals are also implicated in exclusion and inheritance functions. In trypanosomes, these factors sustain a highly effective and paradigmatic immune evasion strategy.
A systematic approach to orient the human protein–protein interaction network
Authors: Silverbush Dana , Sharan Roded 
Published: July 2019

AbstractThe protein-protein interaction (PPI) network of an organism serves as a skeleton for its signaling circuitry, which mediates cellular response to environmental and genetic cues. Understanding this circuitry could improve the prediction of gene function and cellular behavior in response to diverse signals. To realize this potential, one has to comprehensively map PPIs and their directions of signal flow. While the quality and the volume of identified human PPIs improved dramatically over the last decade, the directions of these interactions are still mostly unknown, thus precluding subsequent prediction and modeling efforts. Here we present a systematic approach to orient the human PPI network using drug response and cancer genomic data. We provide a diffusion-based method for the orientation task that significantly outperforms existing methods. The oriented network leads to improved prioritization of cancer driver genes and drug targets compared to the state-of-the-art unoriented network.
Conditions for void formation in friction stir welding from machine learning
Authors: Du Yang , Mukherjee Tuhin , DebRoy Tarasankar 
Published: July 2019

AbstractFriction stir welded joints often contain voids that are detrimental to their mechanical properties. Here we investigate the conditions for void formation using a decision tree and a Bayesian neural network. Three types of input data sets including unprocessed welding parameters and computed variables using an analytical and a numerical model of friction stir welding were examined. One hundred and eight sets of independent experimental data on void formation for the friction stir welding of three aluminum alloys, AA2024, AA2219, and AA6061, were analyzed. The neural network-based analysis with welding parameters, specimen and tool geometries, and material properties as input predicted void formation with 83.3% accuracy. When the potential causative variables, i.e., temperature, strain rate, torque, and maximum shear stress on the tool pin were computed from an approximate analytical model of friction stir welding, 90 and 93.3% accuracies of prediction were obtained using the decision tree and the neural network, respectively. When the same causative variables were computed from a rigorous numerical model, both the neural network and the decision tree predicted void formation with 96.6% accuracy. Among these four causative variables, the temperature and maximum shear stress showed the maximum influence on void formation.
Postbiotic L. plantarum RG14 improves ruminal epithelium growth, immune status and upregulates the intestinal barrier function in post-weaning lambs
Authors: Izuddin Wan Ibrahim , Loh Teck Chwen , Foo Hooi Ling , Samsudin Anjas Asmara , Humam Ali Merzza 
Published: July 2019

AbstractWe investigate the effects of postbioticLactobacillus plantarumRG14 on gastrointestinal histology, haematology, mucosal IgA concentration, microbial population and mRNA expression related to intestinal mucosal immunity and barrier function. Twelve newly weaned lambs were randomly allocated to two treatment groups; the control group without postbiotic supplementation and postbiotic group with supplementation of 0.9% postbiotic in the diet over a 60-day trial. The improvement of rumen papillae height and width were observed in lambs fed with postbiotics. In contrast, no difference was shown in villi height of duodenum, jejunum and ileum between the two groups. Lambs received postbiotics had a lower concentration of IgA in jejunum but no difference in IgA concentration in serum and mucosal of the rumen, duodenum and ileum. In respect of haematology, postbiotics lowered leukocyte, lymphocyte, basophil, neutrophil and platelets, no significant differences in eosinophil. The increase in of IL-6 mRNA and decrease of IL-1β, IL-10, TNF mRNA were observed in the jejunum of lambs receiving postbiotics. Postbiotics also improved the integrity of the intestinal barrier by the upregulation of TJP-1, CLDN-1 and CLDN-4 mRNA. Postbiotic supplementation derived fromL. plantarumRG14 in post-weaning lambs enhance the ruminal papillae growth, immune status and gastrointestinal health.
Whole-Exome Sequencing of Nasopharyngeal Carcinoma Families Reveals Novel Variants Potentially Involved in Nasopharyngeal Carcinoma
Authors: Yu Guoqin , Hsu Wan-Lun , Coghill Anna E. , Yu Kelly J. , Wang Cheng-Ping , Lou Pei-Jen , Liu Zhiwei , Jones Kristie , Vogt Aurelie , Wang Mingyi , Mbulaiteye Sam M. , Chen Hao-Hui , Boland Joseph , Yeager Meredith , Diehl Scott R. , Chen Chien-Jen , Hildesheim Allan , Goldstein Alisa M. 
Published: July 2019

AbstractGenetic susceptibility is likely involved in nasopharyngeal carcinoma (NPC), a cancer caused by Epstein-Barr virus (EBV) infection. Understanding of genetic factors involved in NPC and how they contribute to EBV-induced carcinogenesis is limited. We conducted whole-exome capture/sequencing among 251 individuals from 97 multiplex families from Taiwan (205 affected, 21 obligate carriers, and 25 unaffected) using SeqCap EZ Human Exome Library v3.0 and Illumina HiSeq. Aligned sequences were filtered to identify likely-to-be-functional deleterious variants that co-segregated with disease. Ingenuity Pathway analysis was performed. Circulating magnesium levels were measured in 13 individuals in 2 families with NIPAL1 mutations and in 197 sporadic NPC cases and 237 controls. We identified variants in 12 genes likely involved in cancer pathogenesis, viral infection or immune responses to infection. These included genes postulated to be involved in magnesium transport (NIPAL1), EBV cell entry (ITGB6), modulation of EBV infection (BCL2L12, NEDD4L), telomere biology (CLPTM1L, BRD2, HNRNPU), modulation of cAMP signaling (RAPGEF3), DNA repair (PRKDC, MLH1), and Notch signaling (NOTCH1, DLL3). Pathway based analysis demonstrated enrichment for Notch signaling genes (p-value = 0.0006). Evaluation of individuals within NIPAL1 families suggested lower serum magnesium in NPC compared to unaffected members. A significant reduction in serum magnesium levels was observed among sporadic NPC cases compared to controls (7.1% NPC/1.7% controls below normal range; OR = 4.5; 95% CI = 1.4,14) and is consistent with findings demonstrating a role for magnesium channeling in T-cell responses to EBV. We identified novel genes associated with NPC that point to new areas of inquiry to better understand genetic factors that determine the fate of viral infections and/or otherwise predisposes to NPC.