bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anomalous coronary artery originating from the opposite sinus of Valsalva (ACAOS), fractional flow reserve‐ and intravascular ultrasound‐guided management in adult patients
Authors: Driesen Bart W. , Warmerdam Evangeline G. , Sieswerda Gert‐Jan T. , Schoof Paul H. , Meijboom Folkert J. , Haas Felix , Stella Pieter R. , Kraaijeveld Adriaan O. , Evens Fabiola C. M. , Doevendans Pieter A. F. M. , Krings Gregor J. , van Dijk Arie P. J. , Voskuil Michiel 
Published: March 2018

AbstractObjectivesTo describe the use of fractional flow reserve (FFR) and intravascular ultrasound (IVUS) in the evaluation of patients with anomalous coronary arteries originating from the opposite sinus of Valsalva (ACAOS).BackgroundACAOS of the right and left coronary are rare, but may lead to symptoms and impose a risk for sudden cardiac death, depending on several anatomical features. Assessment and risk estimation is challenging in (nonathlete) adults, especially if they present without symptoms or with atypical complaints.MethodsThe team retrospectively studied 30 consecutive patients with ACAOS with interarterial course, who received IVUS‐ and FFR‐guided treatment at our institution between October 2010 and September 2017.ResultsFFR was abnormal in only seven patients. IVUS showed the typical slit‐like anatomy of the orifice in 23 patients. Based on FFR and/or IVUS results, in conjunction with the clinical presentation, clinical decision was made. A decision for intervention was made if at least two out of three entities were abnormal. Intervention implied unroofing of the coronary artery (n = 10) or coronary artery bypass grafting (n = 1). In all other patients a conservative strategy was followed. No adverse events occurred in the total population after a median of 37 (0–62) months of follow‐up.ConclusionsConservative treatment may be justifiable in adult patients with ACAOS in the presence of normal FFR and nonsuspicious symptoms, despite the presence of an interarterial course and/or slitlike orifice on IVUS. We recommend the use of FFR and IVUS in the standard work‐up for adult patients with ACAOS and propose the use of a flowchart to aid in decision‐making.
Generalized tetanus in adults without antitetanus booster vaccination in southern Mauritania
Authors: Boushab Boushab Mohamed , Fall‐Malick Fatim‐Zahra , Savadogo Mamoudou , Basco Leonardo K. 
Published: March 2018

Key Clinical MessageTetanus has become rare in countries with high levels of vaccination coverage and hygiene but may still occur in adults without booster vaccination. In addition to the expanded program on immunization for children and maternal immunization against neonatal tetanus, a systematic vaccination of the population, including boosters, is recommended.
Electrospun BiOCl/Bi2Ti2O7 Nanorod Heterostructures with Enhanced Solar Light Efficiency in the Photocatalytic Degradation of Tetracycline Hydrochloride
Authors: Xu Yuxian , Lin Daifeng , Liu Xinping , Luo Yongjin , Xue Hun , Huang Baoquan , Chen Qinghua , Qian Qingrong 
Published: March 2018

AbstractBismuth titanates (BTs) can be fabricated by electrospinning combined with calcination at different temperatures. BiOCl/Bi2Ti2O7 nanorod heterostructures were obtained at 500 °C. They possess excellent photocatalytic efficiency and stability for tetracycline hydrochloride (TC‐HCl) degradation under simulated solar light. The excellent catalytic activity is predominantly attributed to the heterostructure between BiOCl and Bi2Ti2O7, which accelerates the separation of photogenerated carriers while the narrow band gap of Bi2Ti2O7 enhances solar energy utilization. On the basis of energy band engineering, scavenger tests, and LC‐HRMS analysis, a possible degradation pathway of TC‐HCl and photocatalytic mechanism were proposed. Our work can predict a facile route for achieving high photocatalytic performance of Bi2Ti2O7‐based materials in the application of TC‐HCl degradation.
Investigation of the Redox and Acid‐Base properties of TCNQF and TCNQF2: Electrochemistry, Vibrational Spectroscopy, and Substituent Effects
Authors: Vo Nguyen , Haworth Naomi L. , Bond Alan M. , Martin Lisandra L. 
Published: March 2018

AbstractThe electrochemistry and acid‐base chemistry of TCNQF and TCNQF2 (TCNQ=7,7,8,8‐tetracyanoquinodimethane) are described, and the results are compared to those reported previously for TCNQ and TCNQF4. In acetonitrile solution, both mono‐ and di‐fluorinated TCNQ derivatives show two well‐resolved, diffusion‐controlled chemically and electrochemically reversible one‐electron‐transfer processes under the conditions of cyclic voltammetry. The reversible potentials of the mono‐ and difluoro‐TCNQ were determined for both the monoanionic and dianionic processes, that is, TCNQF0/1−/2− and TCNQF20/1−/2−. A Hammett plot shows a linear relationship of the potential differences between the three fluorinated derivatives and TCNQ with the sum of the Hammett constants for fluoro substitution. A significant positive shift in the reversible potential is found by increasing the number of fluoro substituents. Although the first TCNQFn0/1− (n=1,2) reduction process is not affected by addition of trifluoroacetic acid (TFA), the dianions are more basic and rapidly protonate to form H2TCNQFn. This explains the significant change detected in the electrochemistry of the second TCNQFn1−/2− redox process. The addition of TFA to solutions of the monoanionic form also gives rise to the disproportionation of TCNQFn1− to TCNQFn and H2TCNQFn, as proven electrochemically and spectroscopically. Furthermore, a higher number of fluoro substituents results in the reduced form of the molecule being more stable, as evidenced by both UV/Vis spectra and voltammetric measurements. Finally, we performed DFT calculations for TCNQF2 and TCNQF2 to produce a spectroscopic library of characteristic IR and Raman bands for these species. These data are used for comparisons with earlier calculations for TCNQF4, and we report the experimental and calculated infrared and Raman spectra for TCNQF and TCNQF2. The vibrational frequencies of the trifluorinated species, TCNQF3, were also calculated to complete the series.
Simulation of kinetic behavior of natural surfactants adsorption using a new robust approach
Authors: Daryasafar Navid , Borazjani Omid , Daryasafar Amin 
Published: March 2018

AbstractSurfactant‐based enhanced oil recovery techniques are known as promising methods for mobilizing the trapped oil in porous media. Surfactants can improve oil recovery by modifying the wettability of rock minerals and also by reducing the interfacial tension between injected water and the trapped oil. Natural surfactants have been introduced as good candidates for enhanced oil recovery applications. In addition, they are less expensive and also have less detrimental environmental effects in comparison with the industrial surfactants. Various empirical models have been proposed for simulating the kinetic behavior of surfactants adsorption, but these models suffer from overestimation and underestimation and they cannot be generalized for even a type of surfactant. Therefore, it is crucial to develop a new model that can overcome these issues. In this study, a new simple, rapid, and accurate model based on least square support vector machines (LSSVMs) was developed for predicting the kinetic adsorption density of natural surfactants on both sandstone and carbonate minerals. Coupled simulated annealing algorithm (CSA) is used for tuning the parameters of the model. Predicted values by this model were in an excellent agreement with experimental values with a coefficient of determination of 0.990. The results demonstrated that the proposed LSSVM‐CSA model has the best performance in comparison with the other well‐established kinetic models. Furthermore, the model reliability was investigated over input parameters changes and showed the acceptable efficiency of the proposed model.
Design, Synthesis, and in vitro Evaluation of Multivalent Drug Linkers for High‐Drug‐Load Antibody–Drug Conjugates
Authors: Chen Bo , Gianolio Diego A. , Stefano James E. , Manning Charlene M. , Gregory Richard C. , Busch Michelle M. , Brondyk William H. , Miller Robert J. , Dhal Pradeep K. 
Published: March 2018

AbstractA series of novel multivalent drug linkers (MDLs) containing cytotoxic agents were synthesized and conjugated to antibodies to yield highly potent antibody–drug conjugates (ADCs) with drug/antibody ratios (DARs) higher than those typically reported in the literature (10 vs. ≈4). These MDLs contain two copies of a cytotoxic agent attached to biocompatible scaffolds composed of a branched peptide core and discrete polyethylene glycol (PEG) chains to enhance solubility and decrease aggregation. These drug linkers produced well‐defined ADCs, whose DARs could be accurately determined by LC–MS. Using this approach, ADCs with significantly lower aggregation and higher DAR than those of conventional drug linker design were obtained with highly hydrophobic cytotoxic agents such as monomethyldolastatin 10 (MMAD). The in vitro potencies of the MDL‐derived conjugates matched that of ADCs of similar DAR with conventional linkers, and the potency increased proportionally with drug loading. This approach may provide a means to prepare highly potent ADCs from a broader range of drugs, including those with lower cytotoxicity or poor solubility, which otherwise limits their use for antibody–drug conjugates. This may also provide a means to further improve the potency achievable with cytotoxins currently used in ADCs.
A (+)‐Larixol Congener with High Affinity and Subtype Selectivity toward TRPC6
Authors: Häfner Stephanie , Burg Finn , Kannler Martina , Urban Nicole , Mayer Peter , Dietrich Alexander , Trauner Dirk , Broichhagen Johannes , Schaefer Michael 
Published: March 2018

AbstractNatural products have many health benefits, and their application can improve the quality of life. Recently, the diterpene (+)‐larixol and its acetylated congeners demonstrated selective inhibition of the second‐messenger‐gated cation channel transient receptor potential canonical 6 (TRPC6) over its close isoforms TRPC3 and TRPC7. Building on this knowledge, we expanded these findings by chemical diversification of (+)‐larixol mostly at position C6. Implementing high‐throughput Ca2+ FLIPR screening assays and electrophysiological patch‐clamp recordings, we showcase larixyl N‐methylcarbamate, termed SH045, as a compound with nanomolar affinity and 13‐fold subtype selectivity over TRPC3 in stably expressing HEK293 cells. Expanding on this finding, TRPC6 inhibition was also observed in rat pulmonary smooth muscle cells. Furthermore, treatment of isolated perfused lung preparations with SH045 led to a decrease in lung ischemia‐reperfusion edema (LIRE), a life‐threatening condition associated with TRPC6 that may occur after organ transplantation. Taken together, and given the inexpensive, straightforward, and scalable preparation of SH045, we report a TRPC6 blocker that holds promise for the translational treatment of LIRE.
Safety, Tolerability, and Pharmacokinetics of 3 g of Ceftolozane/Tazobactam in Healthy Adults: A Randomized, Placebo‐Controlled, Multiple‐Dose Study
Authors: Yu Brian , Adedoyin Adedayo , Hershberger Ellie , Caro Luzelena , Xiao Alan , Rhee Elizabeth G. , Huntington Jennifer A. 
Published: March 2018

AbstractCeftolozane/tazobactam is an antibacterial approved at 1.5 g (1g/0.5 g) every 8 hours (q8h); higher doses may provide additional benefits in difficult‐to‐treat infections. We conducted a phase I trial in healthy adults evaluating safety, tolerability, and pharmacokinetics of 3 g (2 g/1 g) ceftolozane/tazobactam administered q8h for 10 days. Sixteen participants were randomized (2:1:1) to 3 g ceftolozane/tazobactam, 1.5 g ceftolozane/tazobactam, or placebo. Participants underwent regular safety and plasma drug level assessments, with a follow‐up safety visit 7 days after completion. No adverse events (AEs) were reported with placebo; 75% of participants in the 1.5‐g and 50% in the 3‐g arm experienced AEs. AE types were similar between the ceftolozane/tazobactam groups; all AEs were mild. No participants experienced clinically meaningful laboratory assessment or electrocardiogram abnormalities. Both ceftolozane and tazobactam exhibited dose‐proportional pharmacokinetics without accumulation and without substantial differences in clearance and volume of distribution between groups. In the 3‐g group, mean ceftolozane parameters were: peak concentration 104 μg/mL (day 1), 112 μg/mL (day 10); half‐life 3 hours (day 10); area under the concentration‐time curve (AUC(0‐t)) 272 μg·h/mL (day 1), 300μg·h/mL (day 10). Mean tazobactam parameters were: peak concentration 28 μg/mL (day 1), 26 μg/mL (day 10); half‐life 1 hour (day 10); AUC(0‐t) 47μg·h/mL (day 1), 41μg·h/mL (day 10). Administration of 3 g ceftolozane/tazobactam q8h for 10 days was safe and well tolerated in healthy volunteers.
Naphthalimide‐Tertiary Amine Derivatives as Blue‐Light‐Sensitive Photoinitiators
Authors: Zhang Jing , Zivic Nicolas , Dumur Frédéric , Xiao Pu , Graff Bernadette , Fouassier Jean Pierre , Gigmes Didier , Lalevée Jacques 
Published: March 2018

AbstractThe photochemical mechanism of the radical generation from photoinitiating systems based on 1, 8‐naphthalimide derivatives (ANDs; with tertiary amine moieties) are investigated by using various approaches including cyclic voltammetry, steady‐state photolysis, and electron spin resonance spin‐trapping techniques. It reveals that radicals can be produced from ANDs alone or ANDs/additive (e. g. iodonium salt or chloro triazine) combinations. The generated radicals and cations can initiate both free‐radical and cationic photopolymerization reactions under irradiation with various light‐emitting diodes or a halogen lamp. For most of the AND‐based photoinitiating systems, more than 60 % of acrylate or epoxide conversions were attained, and were even higher than those obtained by using commercial photoinitiators, for example, bisacylphosphine oxide or camphorquinone. More interestingly, the AND1‐based photoinitiating system can also initiate concomitant cationic/radical polymerizations and can be used for the synthesis of interpenetrated polymer networks.
Reactions of Disulfides with Silyl Phosphites to Generate Thiophosphates Under Neat Conditions
Authors: Zhan Zhen , Yang Zhongzhen , Ma Dena , Zhang Hao , Shi Yuesen , Wang Qiantao , Deng Yong , Hai Li , Wu Yong 
Published: March 2018

AbstractAn efficient procedure for the synthesis of thiophosphates is described. Without using any metallic catalyst or base, the direct sulfur–phosphorus coupling reaction of disulfides and dialkyl trimethylsilyl phosphite (DTSP) was carried out under solvent‐free reaction conditions in moderate to excellent yields with good functional group compatibility. The reaction conditions represent an advance over established methods not only in omitting the need for expensive catalysts or solvents, but also in shortening the reaction time significantly.These transformations are easy to conduct and can be readily applied to gram‐scale preparation.
Interaction of systolic blood pressure and resting heart rate with clinical outcomes in takotsubo syndrome: insights from the International Takotsubo Registry
Authors: Böhm Michael , Cammann Victoria L. , Ghadri Jelena R. , Ukena Christian , Gili Sebastiano , Di Vece Davide , Kato Ken , Ding Katharina J. , Szawan Konrad A. , Micek Jozef , Jurisic Stjepan , D'Ascenzo Fabrizio , Frangieh Antonio H. , Rechsteiner Delia , Seifert Burkhardt , Ruschitzka Frank , Lüscher Thomas , Templin Christian ,   on behalf of the InterTAK Collaborators
Published: March 2018

AimsThe present study aimed to determine the prognostic impact of resting heart rate (HR) and systolic blood pressure (SBP) in takotsubo syndrome (TTS).Methods and resultsPatients from the International Takotsubo Registry with complete data on HR and SBP were enrolled. We analysed all‐cause mortality and major adverse cardiac and cerebrovascular events (MACCE) in tertiles of HR (<77 b.p.m., 77–94 b.p.m., >94 b.p.m.) and SBP (<119 mmHg, 119–140 mmHg, >140 mmHg). In addition, linear splines with interactions between HR and SBP were analysed. The risk of all‐cause mortality was higher in the second HR tertile (1.89, 1.15–3.10; P = 0.012) and the third HR tertile (3.01, 1.90–4.79; P < 0.001) than in the first tertile. Similar effects were observed for MACCE. Low SBP was related to an increased risk of all‐cause mortality (P < 0.001) and MACCE (P = 0.002). In a multivariable analysis of all‐cause mortality, at HR >70 b.p.m., every 1 b.p.m. increase in HR was associated with a 1.7% increase (P < 0.001), and every 1 mmHg increase in SBP up to 130 mmHg was associated with a 2% risk reduction (P < 0.001). The risk of all‐cause mortality thus was particularly elevated when low SBP occurred together with high HR.ConclusionsHigh HR and low SBP are associated with an increased risk of all‐cause mortality in TTS. HR reduction might be worthy of being investigated as a therapeutic strategy for this condition and high HR and low SBP can be used to evaluate risk in this acute presentation of TTS.Clinical trial registration: ClinicalTrials.gov NCT01947621.
Miscarriage induced by adoptive transfer of dendritic cells and invariant natural killer T cells into mice
Authors: Negishi Yasuyuki , Ichikawa Tomoko , Takeshita Toshiyuki , Takahashi Hidemi 
Published: March 2018

AbstractUnexpected fetal loss is one of the common complications of pregnancy; however, the pathogenesis of many miscarriages, particularly those not associated with infections, is unknown. We previously found that activated DEC‐205+ dendritic cells (DCs) and NK1.1+ invariant natural killer T (iNKT) cells are recruited into the myometrium of mice when miscarriage is induced by the intraperitoneal administration of α‐galactosylceramide (α‐GalCer). Here we demonstrate that the adoptive transfer of DEC‐205+ bone marrow‐derived DCs cocultured with α‐GalCer (DEC‐205+ BMDCs‐c/w‐α‐GalCer) directly induced marked fetal loss by syngeneic pregnant C57BL/6 (B6) mice and allogeneic mice (B6 (♀) × BALB/c (♂)), which was accompanied by the accumulation of activated iNKT cells in the myometrium. Further, the adoptive transfer of NK1.1+ iNKT cells obtained from B6 mice injected with α‐GalCer facilitated miscarriages in syngeneic Jα18(−/−) (iNKT cell‐deficient) mice. These results suggest that DEC‐205+ DCs and NK1.1+ iNKT cells play crucial roles required for the initiation of fetal loss associated with stimulation by glycolipid antigens and sterile inflammation.
Photolabile Ru Model Complexes with Chelating Diimine Ligands for Light‐Triggered Drug Release
Authors: Battistin Federica , Balducci Gabriele , Wei Jianhua , Renfrew Anna K. , Alessio Enzo 
Published: March 2018

AbstractInvited for the cover of this issue is the group of Enzo Alessio, University of Trieste, Italy, collaborating with the group of Anna Renfrew, University of Sydney, Australia. The cover image shows how a drug “chained” to an inert Ru complex can be photo‐released upon illumination.
Delineation between different components of chronic pain using dimension reduction – an ASL fMRI study in hand osteoarthritis
Authors: Keszthelyi D. , Aziz Q. , Ruffle J.K. , O'Daly O. , Sanders D. , Krause K. , Williams S.C.R. , Howard M.A. 
Published: March 2018

AbstractBackgroundTraditional psychometric measures aimed at characterizing the pain experience often show considerable overlap, due to interlinked affective and modulatory processes under central nervous system control. Neuroimaging studies have been employed to investigate this complexity of pain processing, in an attempt to provide a quantifiable, adjunctive description of pain perception. In this exploratory study, we examine psychometric and neuroimaging data from 38 patients with painful osteoarthritis of the carpometacarpal joint. We had two aims: first, to utilize principal component analysis (PCA) as a dimension reduction strategy across multiple self‐reported endpoints of pain, cognitive and affective functioning; second, to investigate the relationship between identified dimensions and regional cerebral blood flow (rCBF) as an indirect measure of brain activity underpinning their ongoing pain experiences.MethodsPsychometric data were collected using validated questionnaires. Quantitative estimates of rCBF were acquired using pseudo‐continuous arterial spin‐labelled functional magnetic resonance imaging.ResultsTwo principal components were identified that accounted for 73% of data variance; one related to pain scores and a second to psychological traits. Voxel‐wise multiple regression analysis revealed a significant negative association between the ‘pain score’ component and rCBF to a right temporal lobe cluster, including the amygdala and the parahippocampal cortex.ConclusionWe suggest this association may represent a coping mechanism that aims to reduce fear‐related pain‐anxiety. Further investigation of central brain processing mechanisms in osteoarthritis‐related pain may offer insights into more effective therapeutic strategies.SignificanceThis study demonstrates that dimension reduction using PCA allows insight into pain perception and its affective components in relation to brain activation patterns in patients with painful hand osteoarthritis.
The effect of self‐identity alongside perceived importance within the theory of planned behaviour
Authors: Reid Matthew , Sparks Paul , Jessop Donna C. 
Published: March 2018

AbstractSelf‐identity often predicts behavioural intentions after standard theory of planned behaviour (TPB) components are accounted for. However, it has been claimed this is due to conceptual similarity between self‐identity and perceived importance of the behaviour. We examined this claim within the context of recycling food waste. Participants (N = 113) completed questionnaires assessing intentions, attitude, perceived behavioural control, perceived norms, perceived importance, self‐identity, and past behaviour. Confirmatory factor analysis indicated that self‐identity and perceived importance were distinct constructs. Further, after accounting for TPB components and perceived importance, self‐identity explained a significant amount of additional variance in intentions. The present findings therefore do not support this particular argument against the predictive utility of self‐identity.
Monkey see, monkey do: The effect of social influence on selective‐exposure bias
Authors: Adams John Milton , Hart Will , Richardson Kyle , Tortoriello Gregory K. , Rentschler Abby 
Published: March 2018

AbstractSelective‐exposure bias refers to the tendency to predominantly seek out attitude‐consistent information and avoid attitude‐inconsistent information. Although researchers have proposed and tested several underlying psychological factors that might contribute to this tendency, the potential role of social influence has not been addressed. In the present research, we address this issue. In four experiments (total N = 645), participants’ selective‐exposure bias was significantly reduced when the bias was portrayed as non‐normative (vs. normative). In Experiment 4, we obtained evidence for the possibility that this social‐norm manipulation could result in effects on attitudes through information selection. Overall, this research contributes novel evidence for the effect of social influence on selective‐exposure bias.