bluuebunny/crossref_metadata_2025_split huggingface dataset:
Keanekaragaman Spesies Mangrove dan Zonasi di Wilayah Kelurahan Mangunharjo Kecamatan Tugu Kota Semarang
Authors: Tefarani Rahmadyan , Tri Martuti Nana Kariada , Ngabekti Sri 
Published: April 2019

Tugu sub-district has a mangrove ecosystem that is better than the other three sub-districts in Semarang City. The improvement of the mangrove ecosystem in Mangunharjo Village became the main of priority for mangrove rehabilitation This study aimed to determine the level of diversity of mangrove species found in the mangrove ecosystem of Mangunharjo Sub-District, Tugu District, Semarang City based on the zonation. The study was conducted in February-March 2018. Sampling using a combination method, that are systematic sampling with vegetation analysis techniques using quadrat sampling technique. There are three data collection stations determined based on the distance from the coastline to the mainland. Data were analyzed using quantitative descriptive statistics. The results showed that the diversity of mangrove species found in Mangunharjo Village had a low to moderate diversity level (0.72-1.32). The mangrove ecosystem in Mangunharjo is actually artificial ecosystem, with the type and number of mangroves dominated by Rhizophora mucronata and Avicennia marina. There are seven mangrove species found in the open zone, four species in the middle zone and four species in the land zone.

Kecamatan Tugu memiliki ekosistem mangrove yang masih baik dibandingkan dengan tiga kecamatan lainnya yang berada di Kota Semarang. Perbaikan ekosistem mangrove di Kelurahan Mangunharjo menjadi prioritas utama rehabilitasi mangrove. Penelitian ini bertujuan untuk menentukan tingkat keanekaragaman spesies mangrove yang terdapat di ekosistem mangrove Kelurahan Mangunharjo Kecamatan Tugu Kota Semarang berdasarkan zonasinya. Penelitian dilakukan pada bulan Februari–Maret 2018. Pengambilan sampel menggunakan metode kombinasi, yaitu antara systematic sampling dengan teknik analisis vegetasi menggunakan quadrat sampling technique. Terdapat tiga stasiun pengambilan data yang ditentukan berdasarkan jarak dari garis pantai hingga daratan. Data dianalisis secara statistik deskriptif kuantitatif. Hasil penelitian menunjukan bahwa keanekaragaman spesies mangrove yang terdapat di Kelurahan Mangunharjo mempunyai tingkat keanekaragaman rendah hingga sedang (0.72-1.32). Hal ini dikarenakan ekosistem mangrove wilayah Mangunharjo merupakan ekosistem buatan, dengan jenis dan jumlah mangrove yang dominasi oleh Rhizophora mucronata dan Avicennia marina. Terdapat tujuh spesies mangrove yang ditemukan pada zona terbuka, empat spesies pada zona tengah dan empat spesies pada zona daratan.
GALLIUM-67 CITRATE USED AS A TRACER OF ACETONE PRODUCTION ROUTE
Authors: Mesquita Carlos Henrique de , Calvo Wilson Aparecido Parejo , Aoki Pedro Eiti , Silva Valdir Cosmo da , Haraguchi Márcio Issamu , Velo Alexandre França , Alvarez Alexandre Gimenes , Hamada Margarida Mizue 
Published: April 2019

In this work the pathway of the chemical product and the kinetics parameters were evaluated in a laboratory plant settled, using 0.4 GBq (10 mL) of 67Ga citrate as radiotracer and 18 NaI(Tl) radiation detectors. The AnaComp program was used to estimate the kinetic para ameters of the acetone production. The yield of the acetone production was estimated by the percentage ratio between the areas under the curve (AUC) of the curve profiles of the final product compartment divided by the concentration found inside the chemical reactor whose result was 87% yield during the first 30 minutes of reaction.
The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG
Authors: SOARES Jaqueline Jamara SOUZA 
Published: April 2019

The functionalization of graphene oxide (GO) with polyethylene glycol (PEG) has been widely used in drug delivery systems. This nanocomposite exhibits excellent stability in the presence of high concentrations of salts and proteins and shows to be less toxic than its raw form in vitro and in vivo. However, it must be sterilized before use in the medical field and the gamma irradiation shows a promising option for this purpose. Sterilization by ionizing energy through gamma rays, generated by Cobalt-60 self-disintegration, consists in exposing the materials to short electromagnetic waves. The irradiation process provides substantial advantages when compared to thermal and chemical processes such as more precise control of the process, production of products with superior qualities, lower energy consumption and less environmental pollution. In this work the effect of gamma radiation on the structure of GO and GO functionalized com Amino-PEG (GO-PEG-NH2) irradiated with different doses (15, 25, 35 and 50 kGy) and rate dose 7.31 kGy.h - 1 was evaluated. The analyses were performed by Fourier-transform infrared spectroscopy (FT-IR) and Raman spectroscopy. The results showed that the methods for the synthesis of GO and GO-PEG-NH2 was effective since there was confirmation of the surface oxidation of materials and functionalization with the PEG-NH2 and the sterilization by gamma radiation does not caused any defects on materials.
Thermoluminescent properties of LaAlO3:C crystals synthesized by solid state reaction applied to UV Dosimetry
Authors: Alves Neriene , Ferraz Wilmar Barbosa , Faria Luiz Oliveira 
Published: April 2019

In this work, the thermoluminescent (TL) response of carbon doped lanthanum aluminate crystals grown by solid state reaction method was investigated. Three syntheses using different combinations of Al2O3, La2O3 and 0.1 wt % of carbon atoms were conducted. The 1:1 mixture of aluminum and lanthanum oxide was mixed with 0.1wt.% carbon and annealed at 1700°C for two hours in a hydrogen atmosphere. The X-ray diffraction analysis revealed the formation of the rhombohedral LaAlO3 crystallographic phase. Ultraviolet-visible spectroscopies were obtained and F and F+ centers were identified ascribed. Fourier transform infrared spectroscopic data show higher and lower frequencies assigned to AlO6 octahedra in LaAlO3. The UV irradiations were carried out using a commercial 8W UV lamp. Thermoluminescence measurements were performed at a Harshaw 4500 TL reader. The three syntheses were very efficient to obtain carbon doped LaAlO3 crystals with high thermoluminescent output, for low exposure rates of UVR fields.
Genetic Profiling of Non-Small Cell Lung Cancer at Development of Resistance to First- or Second-Generation EGFR-TKIs by CAPP-Seq Analysis of Circulating Tumor DNA
Authors: Otsubo Kohei , Sakai Kazuko , Takeshita Masafumi , Harada Daijiro , Azuma Koichi , Ota Keiichi , Akamatsu Hiroaki , Goto Koichi , Horiike Atsushi , Kurata Takayasu , Nakagaki Noriaki , Nosaki Kaname , Iwama Eiji , Nakanishi Yoichi , Nishio Kazuto , Okamoto Isamu 
Published: April 2019

Abstract

Patients with non-small cell lung cancer (NSCLC) treated with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) eventually acquire resistance to these drugs. The identification of various resistance mechanisms for determination of subsequent treatment for these patients will require a method for simultaneous detection of multiple genetic alterations with high sensitivity. We performed cancer personalized profiling by deep sequencing (CAPP-Seq) with circulating tumor DNA obtained from patients with NSCLC who acquired resistance to first- or second-generation EGFR-TKIs. Plasma samples from 27 patients were analyzed, and 24 samples underwent CAPP-Seq successfully. Original activating EGFR mutations were detected in 23 patients, with the remaining patient showing MET amplification. With regard to known mechanisms of EGFR-TKI resistance, the T790M mutation of EGFR was detected in 17 of the 24 patients, MET amplification in 9 patients (6 of whom also harbored T790M), ERBB2 amplification in 2 patients (1 of whom also harbored T790M), and EGFR amplification in 4 patients (all of whom harbored T790M). Our results thus show that CAPP-Seq is applicable to clinical samples for the identification of multiple somatic mutations in circulating tumor DNA obtained from patients with NSCLC at the time of disease progression during treatment with first- or second-generation EGFR-TKIs. Patients positive for the T790M mutation of EGFR were also found to constitute a molecularly heterogeneous population.

Key Points
CAPP-Seq is applicable to clinical samples for the identification of multiple somatic mutations. The T790M mutation of EGFR is associated with amplification of MET, ERBB2, or EGFR in NSCLC patients resistant to EGFR-TKIs. T790M-positive patients are molecularly heterogeneous, and genetic alterations coexisting with T790M may differ between patients treated with first-generation or second-generation EGFR-TKIs.
Türkiye’de Okul Öncesi Eğitimde Dil Gelişimi ile İlgili Yapılan Lisansüstü Tezlerin İncelenmesi
Authors: KAROĞLU Hilal , ESEN ÇOBAN Aysel 
Published: April 2019

Bu çalışmanın amacı, okul öncesi eğitimde dil gelişimi ile ilgili
yapılmış lisansüstü tezlerin incelenmesidir. Dil gelişimi ile ilgili tezlerin
çeşitli boyutlarda incelenmesi ailelere, öğretmenlere ve araştırmacılara
çocukların dil kazanımları ve gelişimleri ile ilgili bilgi ve beceri
kazandıracağından önemli olduğu düşünülmektedir. Araştırma nitel araştırma
desenindedir. Veriler Yök Dokümantasyon sistemi kullanılarak elde edilmiş; okul
öncesi, dil ve eğitim ve öğretim konusu anahtar kelimeler olarak
belirlenmiştir. 7 doktora tezi 37 yüksek lisans tezi toplam 44 lisansüstü tez
araştırmanın örneklemini oluşturmuştur. Araştırmada dil gelişim alanında
yapılan lisansüstü tezlerin belli yıl aralıklarında artış gösterdiği, %64’ ünün
tarama modelinde olduğu, %58’ sinin çalışma grubunu çocukların oluşturduğu,
yabancı dil eğitimi % 20, programların etkisi% 16 ve Türkçe-dil etkinlikleri %
16 en çok incelenen konuları oluşturduğu bulguları elde edilmiştir. Veri
toplama aracı olarak Peabody resim-kelime testi % 20,8, anket%
18,7ve Lügatçe ve dil testleri kullanıldığı % 14,6’tür. Veri analiz yöntemi olarak ise t-testi % 26,7, Anova % 24 ve Korelasyon %12 tekniklerinin
kullanıldığı tespit edilmiştir. Araştırma sonucunda dil gelişimi alanındaki
eksiklikleri giderecek çalışmaların yapılması önerilmektedir.
HOW WOULD OUR STUDENTS LIKE TO BE CORRECTED? : A STUDY ON LEARNERS’ BELIEFS ABOUT LANGUAGE LEARNING STRATEGY
Authors: W. Pratolo Bambang 
Published: April 2019

Purpose: This study aims at finding out whether learners with different English proficiency backgrounds respond differ- ently to corrective feedbacks (CFs) and what kind of CFs are acceptable for them.
Methodology: This study was conducted using a qualitative method with a semi-structured interview and learning journals as the instruments to collect the data. Six students were involved in this study, two of them were high achievers, two were medium achievers, and the other two were low achievers.
Results: The findings showed that all participants in this study believed that they needed CFs from their lecturers and they were confident that CFs was very significant to improve their English competence.
Implications: This study revealed that although most of the participants were alright to receive CFs immediately after they made mistakes, they would do differently if they became teachers. They would wait until their students finish talking before they give CFs or they would do it at the end of the class. The results confirmed that they preferred CFs which were accurate, appreciative, motivating and make them feel comfortable. Finally, this current study also points out that the way how lecturers give feedbacks has to consider the type of mistakes.
The Leukocyte Esterase Test for Periprosthetic Joint Infection Is Not Affected by Prior Antibiotic Administration
Authors: Shahi Alisina , Alvand Abtin , Ghanem Elie , Restrepo Camilo , Parvizi Javad 
Published: April 2019

Background:
It has been demonstrated that administration of antibiotics prior to performing diagnostic testing for periprosthetic joint infection can interfere with the accuracy of the standard diagnostic tests. Therefore, the purpose of this study was to evaluate the effects of antibiotic administration prior to performing the synovial leukocyte esterase strip test for periprosthetic joint infection.

Methods:
We identified 121 patients who underwent revision hip or knee arthroplasty for a Musculoskeletal Infection Society (MSIS)-confirmed periprosthetic joint infection. All patients also had a leukocyte esterase strip test performed. Patients in one group (32%) took antibiotics prior to the diagnostic workup, whereas patients in another group (68%) did not receive antibiotics within 2 weeks of the diagnostic workup. The leukocyte esterase strip test, erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), synovial white blood-cell (WBC) count, and polymorphonuclear neutrophil (PMN) percentage were collected and were compared between the 2 groups.

Results:
The median serum ESR (85 compared with 67 mm/hr for patients who did not and did receive antibiotics; p = 0.009), CRP (16.5 compared with 12.9 mg/L; p = 0.032), synovial WBC count (45,675 compared with 9,650 cells/µL; p < 0.0001), and PMN percentage (93% compared with 88%; p = 0.004) were all significantly lower for patients receiving antibiotics. Furthermore, the administration of antibiotics resulted in a significant decrease in the sensitivity of all tests, except leukocyte esterase: ESR (79.5% in the antibiotics cohort compared with 92.7% in the no-antibiotics cohort [relative risk (RR) for false-negative results, 2.8; p = 0.04]), CRP (64.2% compared with 81.8% [RR, 1.9; p = 0.03]), WBC count (69.3% compared with 93.4% [RR, 5.0; p = 0.001]), PMN percentage (74.4% compared with 91.5% [RR, 3.0; p = 0.01]), and leukocyte esterase (78% compared with 83% [RR, 1.6; p = 0.17]). The rate of negative cultures was higher in the antibiotics group at 30.7% compared with the no-antibiotics group at 12.1% (p = 0.015).

Conclusions:
This current study and previous studies have demonstrated that the administration of premature antibiotics can compromise the results of standard diagnostic tests for periprosthetic joint infection, causing significant increases in false-negative results. However, in this study, the leukocyte esterase strip test maintained its performance even in the setting of antibiotic administration. Antibiotic administration prior to diagnostic workups for periprosthetic joint infection stands to interfere with diagnosis. The leukocyte esterase strip test can be used as a reliable diagnostic marker for diagnosing periprosthetic joint infection even when prior antibiotics are administered.

Level of Evidence:
Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.
New Persistent Opioid Use Following Common Forefoot Procedures for the Treatment of Hallux Valgus
Authors: Finney Fred T. , Gossett Timothy D. , Hu Hsou Mei , Waljee Jennifer F. , Brummett Chad M. , Talusan Paul G. , Holmes James R. 
Published: April 2019

Background:
Orthopaedic surgeons are the fourth highest on the list of top prescribers of opioid analgesics by specialty and have a direct impact on opioid-related morbidity in the United States. Operative bunion correction is one of the most commonly performed elective foot surgical procedures in this country. We sought to determine the rate of new persistent opioid use following exposure to opioids after surgical treatment of hallux valgus (bunionectomy) and to identify associated risk factors.

Methods:
A nationwide U.S. insurance claims database, Truven Health MarketScan, was used to identify opioid-naïve patients who underwent surgical treatment of hallux valgus employing 3 common procedures from January 2010 to June 2015. The rate of new persistent opioid use (i.e., fulfillment of an opioid prescription between 91 and 180 days after the surgical procedure) among patients who filled a perioperative opioid prescription was then calculated. A logistic regression model was used to examine the relationship between new persistent use and risk factors, including surgical procedure, patient demographic characteristics, and patient comorbidities.

Results:
A total of 36,562 patients underwent surgical treatment of hallux valgus and filled a perioperative opioid prescription. The rate of new persistent opioid use among all patients who filled a perioperative opioid prescription was 6.2%. Patients who underwent treatment with a first metatarsal-cuneiform arthrodesis were more likely to have new persistent opioid use compared with the distal metatarsal osteotomy control group (adjusted odds ratio, 1.19 [95% confidence interval, 1.03 to 1.39]; p = 0.021). Factors independently associated with new persistent opioid use included prescribing patterns, coexisting mental health diagnoses, and certain pain disorders.

Conclusions:
New persistent opioid use following surgical treatment of hallux valgus affects a substantial number of patients. Understanding factors associated with persistent opioid use can help clinicians to identify and counsel at-risk patients and to mitigate this public health crisis.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
The Orthopaedic Workforce Is Not as Diverse as the Population It Serves: Where Are the Minorities and the Women?
Authors: Harrington Melvyn A. , Rankin E. Anthony , Ladd Amy L. , Mason Bonnie S. 
Published: April 2019

Abstract:
The lack of sex and racial diversity of the physicians within the specialty of orthopaedic surgery was recognized decades ago, and formal steps to address these issues began in 1983 with the founding of the Ruth Jackson Orthopaedic Society and the J. Robert Gladden Orthopaedic Society. Despite the efforts of these organizations, the work of other interested groups, and the growing diversity in medical student demographics, physician diversity in orthopaedic surgery remains disproportionately poor relative to the populations that we serve as a specialty.
Optimal dose of pretreated-dexmedetomidine in fentanyl-induced cough suppression: a prospective randomized controlled trial
Authors: Zhou Wei , Zhang Dongsheng , Tian Shunping , Yang Yang , Xing Zhi , Ma Rongrong , Zhou Tianqi , Bao Tianxiu , Sun Jianhong , Zhang Zhuan 
Published: April 2019

Abstract
Background: To investigate the optimal dose of pretreated-dexmedetomidine in fentanyl-induced cough (FIC) suppression.
Methods: Patients of 180 undergoing elective surgery with general anesthesia, aged 18-65 years, BMI 18.5-30 kg/m2, ASA I or II, were equally randomized into four groups (n = 45) to receive intravenous pretreatment of dexmedetomidine with 0 (group 1), 0.3 (group 2), 0.6 (group 3) and 0.9 (group 4) mcg/kg over 10 mins, respectively. After the pretreatment, all patients were given a 5-s intravenous injection of fentanyl 4 mcg/kg. The symptoms of irritating cough including the severity and onset time were recorded for 1 min after fentanyl injection. General anesthesia induction was completed with midazolam, propofol and cisatracurium, then endotracheal tube or laryngeal mask was inserted and connected to an anesthesia machine. MAP, HR and SpO2 at the beginning of pretreatment (T0), 3 min (T1), 6 min (T2), 9 min (T3) and 12 min (T4) after the beginning of pretreatment were recorded. Side effects of dexmedetomidine, such as bradycardia, hypertension, hypotension, and respiratory depression were also recorded during the course.
Results: Totally 168 patients completed the study. The incidences of cough were 52.4%, 42.9%, 11.9%, and 14.3% in groups 1, 2, 3, and 4, respectively, with no significant differences between groups 1 and 2 (P > 0.05) and between groups 3 and 4 (P > 0.05). The incidence and severity of cough in groups 3 and 4 were significantly lower than those in groups 1 and 2 (P < 0.05). Compared to T0, HR at T2 (P < 0.05), T3 (P < 0.01), and T4 (P < 0.01) decreased significantly and MAP at T4 decreased significantly (P < 0.05) in group 4. Bradycardia occurred in 1 case and respiratory depression occurred in 1 case in group 4. Compared to group 1, the onset time of cough in the other 3 groups were delayed significantly (P < 0.05).
Conclusion: Pretreated dexmedetomidine 0.6 mcg/kg blous intravenous infusion over 10 mins could reduce FIC effectively without side effects.
Assessment of PrEP eligibility and uptake among at-risk MSM participating in a HIV-1 vaccine feasibility cohort in coastal Kenya
Authors: Wahome Elizabeth , Graham Susan M. , Thiong’o Alexander N. , Chirro Oscar , Mohamed Khamisi , Gichuru Evans , Mwambi John , Price Matt A. , Sanders Eduard J. 
Published: April 2019

Abstract
Introduction

Pre-exposure prophylaxis (PrEP) is provided free of costs to a broad range of at-risk populations in Kenya, including men who have sex with men (MSM), but anal intercourse is not an eligibility criterion. We set out to determine PrEP eligibility, uptake and predictors of PrEP uptake among MSM enrolled in an HIV-1 vaccine feasibility cohort in coastal Kenya.

Methods

We compared the number of MSM identified as eligible for PrEP from June - December 2017 by Kenyan Ministry of Health (MoH) criteria, which do not include reported anal intercourse, to those identified as eligible by a published MSM cohort-derived HIV-1 risk score (CDHRS). We determined PrEP uptake and assessed factors associated with PrEP uptake at first offer among eligible MSM followed up monthly for HIV-1 testing, risk assessment, and risk reduction counselling.

Results

Out of 167 MSM assessed for PrEP eligibility, 118 (70.7%) were identified by both MoH and CDHRS eligibility criteria. However, the CDHRS identified 33 (19.8%) more cohort MSM for PrEP eligibility than the MoH criteria, of whom the majority (24 or 72.7%) reported receptive anal intercourse (RAI). Of the 162 MSM eligible for PrEP, 113 (69.7%) accepted PrEP at first offer. Acceptance of PrEP was higher for men reporting RAI (adjusted prevalence ratio [aPR], 1.4; 95% confidence interval [CI], 1.0–1.9), having paid for sex (aPR, 1.3; 95% CI, 1.1–1.6) and group sex (aPR, 1.4; 95% CI, 1.1–1.8), after adjustment for sociodemographic factors.

Conclusions

Assessing PrEP eligibility using a CDHRS identified 20% more at-risk MSM for PrEP initiation than when Kenyan MoH criteria were used. Approximately 70% of eligible men accepted PrEP at first offer, suggesting that PrEP is acceptable among at-risk MSM. MSM reporting RAI, group sex, or paying for sex were more likely to accept PrEP, reinforcing the importance of an informed discussion of HIV-1 risk during PrEP counselling.