bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward Flexible and Wearable Embroidered Supercapacitors from Cobalt Phosphides-Decorated Conductive Fibers
Authors: Wen Jianfeng , Xu Bingang , Zhou Jinyun 
Published: October 2019

Abstract
Wearable supercapacitors (SCs) are gaining prominence as portable energy storage devices. To develop high-performance wearable SCs, the significant relationship among material, structure, and performance inspired us with a delicate design of the highly wearable embroidered supercapacitors made from the conductive fibers composited. By rendering the conductive interdigitally patterned embroidery as both the current collector and skeleton for the SCs, the novel pseudocapacitive material cobalt phosphides were then successfully electrodeposited, forming the first flexible and wearable in-plane embroidery SCs. The electrochemical measurements manifested that the highest specific capacitance was nearly 156.6 mF cm−2 (65.72 F g−1) at the current density of 0.6 mA cm−2 (0.25 A g−1), with a high energy density of 0.013 mWh cm−2 (5.55 Wh kg−1) at a power density of 0.24 mW cm−2 (100 W kg−1). As a demonstration, a monogrammed pattern was ingeniously designed and embroidered on the laboratory gown as the wearable in-plane SCs, which showed both decent electrochemical performance and excellent flexibility.
Unsupervised network embeddings with node identity awareness
Authors: Gutiérrez-Gómez Leonardo , Delvenne Jean-Charles 
Published: October 2019

Abstract
A main challenge in mining network-based data is finding effective ways to represent or encode graph structures so that it can be efficiently exploited by machine learning algorithms. Several methods have focused in network representation at node/edge or substructure level. However, many real life challenges related with time-varying, multilayer, chemical compounds and brain networks involve analysis of a family of graphs instead of single one opening additional challenges in graph comparison and representation. Traditional approaches for learning representations relies on hand-crafted specialized features to extract meaningful information about the graphs, e.g. statistical properties, structural motifs, etc. as well as popular graph distances to quantify dissimilarity between networks. In this work we provide an unsupervised approach to learn graph embeddings for a collection of graphs defined on the same set of nodes so that it can be used in numerous graph mining tasks. By using an unsupervised neural network approach on input graphs, we aim to capture the underlying distribution of the data in order to discriminate between different class of networks. Our method is assessed empirically on synthetic and real life datasets and evaluated in three different tasks: graph clustering, visualization and classification. Results reveal that our method outperforms well known graph distances and graph-kernels in clustering and classification tasks, being highly efficient in runtime.
Endemic North American Plants as Potentially Suitable Agents for Wound Cleaning Under Resource Scarce Conditions
Authors: Whitehead Aldon J. , Nelson Nathan W. , Brame Lacy S. , Champlin Franklin R. 
Published: October 2019

Introduction Skin and subcutaneous infections are dangerous sequelae of soft tissue injuries, especially in austere situations where medical technology is not available. Numerous plant species endemic to North America have been described as having antibacterial properties. Of these, St. John’s wort ( Hypericum perforatum), chamomile ( Matricaria chamomilla), and white oak ( Quercus alba) were selected for testing against Staphylococcus aureus. Our objective was to assess the suitability of all 3 plants as potential antiseptic agents using methods easily replicated in a resource-scarce environment. Methods Water-soluble natural products were extracted from different concentrations of each plant part using either mechanical agitation at ambient temperature or boiling in unsterilized tap water. Antibacterial activity of each extract against S aureus was assessed using a conventional agar well diffusion bioassay. Zones of inhibition were measured using electronic calipers and were compared to tap water as the negative control. Results Aqueous extracts of St. John’s wort and white oak bark displayed antibacterial effects against S aureus, with St. John’s wort being more potent. Chamomile displayed no inhibitory properties at the concentrations examined. Conclusions These data suggest that both St. John’s wort and white oak are potential candidates for infection prophylaxis and therapy in austere wilderness scenarios, with St. John’s wort being the more potent agent. White oak may be more logistically feasible because the larger surface area of a white oak tree allows for harvesting a larger quantity of bark compared to the smaller surface area of the St. John’s wort plant.
Case–Control Study of Endovascular Thrombectomy in a Canadian Stroke Center
Authors: Hu Sherry X. , Virani Karim , Shankar Jai J. S. , Christian Christine A. , Matheson Kara J. , Cao Huiling , Simpkin Wendy L. , Phillips Stephen J. 
Published: October 2019

ABSTRACT:Background:Although the efficacy of endovascular thrombectomy (EVT) for acute ischemic stroke caused by intracranial anterior circulation large vessel occlusion (LVO) is proven, demonstration of local effectiveness is critical for health system planning and resource allocation because of the complexity and cost of this treatment.Methods:Using our prospective registry, we identified all patients who underwent EVT for out-of-hospital LVO stroke from February 1, 2013 through January 31, 2017 (n= 44), and matched them 1:1 in a hierarchical fashion with control patients not treated with EVT based on age (±5 years), prehospital functional status, stroke syndrome, severity, and thrombolysis administration. Demographics, in-hospital mortality, discharge disposition from acute care, length of hospitalization, and functional status at discharge from acute care and at follow-up were compared between cases and controls.Results:For EVT-treated patients (median age 66, 50% women), the median onset-to-recanalization interval was 247 min, and successful recanalization was achieved in 30/44 (91%). Alteplase was administered in 75% of cases and 57% of controls (p= 0.07). In-hospital mortality was 11% among the cases and 36% in the control group (p= 0.006); this survival benefit persisted during follow-up (p= 0.014). More EVT patients were discharged home from acute care (50% vs. 18%,p= 0.002). Among survivors, there were nonsignificant trends in favor of EVT for median length of hospitalization (14 vs. 41 days,p= 0.11) and functional independence at follow-up (51% vs. 32%,p= 0.079).Conclusion:EVT improved survival and decreased disability. This demonstration of single-center effectiveness may help facilitate expansion of EVT services in similar health-care jurisdictions.
Body mass index and peripheral arterial disease, a “U-shaped” relationship in elderly African population – the EPIDEMCA study
Authors: Desormais Ileana , Aboyans Victor , Guerchet Maëlenn , Ndamba-Bandzouzi Bébène , Mbelesso Pascal , Magne Julien , Jesus Pierre , Marin Benoît , Lacroix Philippe , Preux Pierre Marie ,   EPIDEMCA investigators
Published: October 2019

Summary: Background: There is no study available concerning specifically the role of underweight in PAD prevalence. Patients and methods: Individuals ≥ 65 years living in urban and rural areas of two countries in Central Africa (Central African Republic and the Republic of Congo) were invited. Demographic, clinical and biological data were collected, and ankle-brachial index measured. BMI was calculated as weight/height2and participants were categorized according to the World Health Organization as with underweight (< 18.5 kg/m2), normal weight (18.5–24.9 kg/m2), overweight (25–29.9 kg/m2), and obese (≥ 30 kg/m2). Results: Among the 1815 participants (age 73.0 years, 61.8 % females), the prevalence of underweight was 34.1 %, higher in subjects with PAD than in PAD free subjects (37.1 % vs. 33.5 %, p = 0.0333). The overall prevalence of PAD was 14.3 %. Underweight and obesity were still significantly associated with PAD after adjustment to all potential confounding factors (OR: 2.09, p = 0.0009 respectively OR: 1.90, p = 0.0336) while overweight was no more significantly associated with PAD after multivariate analysis. Conclusions: While obesity is a well-known PAD associated marker, low BMI provides novel independent and incremental information on African subject’s susceptibility to present PAD, suggesting a “U-shaped” relationship between BMI and PAD in this population.
Retrieving Surface Snowfall With the GPM Microwave Imager: A New Module for the SLALOM Algorithm
Authors: Rysman Jean‐François , Panegrossi Giulia , Sanò Paolo , Marra Anna Cinzia , Dietrich Stefano , Milani Lisa , Kulie Mark S. , Casella Daniele , Camplani Andrea , Claud Chantal , Edel Léo 
Published: October 2019

AbstractIn this study, we present a new module for the Snow retrievaL ALgorithm fOr gMi (SLALOM) that retrieves surface snowfall rate using Global Precipitation Measurement (GPM) Microwave Imager measurements together with humidity and temperature vertical profiles. This module, named Surface Snowfall Rate Module, is tuned using colocated surface snowfall observations of the Cloud Profiling Radar onboard CloudSat. Using this new module, the SLALOM algorithm is able to predict surface snowfall rate with a relative bias of −13%, a root‐mean‐square error of 0.08 mm/hr, and a correlation coefficient of 0.7. Surface Snowfall Rate Module is then used to retrieve snowfall rate for three case studies and to provide a unique, 70°S to 70°N high‐resolution distribution of average surface snowfall rate from 2014 to 2017. This new product will be useful for surface precipitation analyses, global water budget estimation, and climatological analyses.
Jovian Auroral Radio Sources Detected In Situ by Juno/Waves: Comparisons With Model Auroral Ovals and Simultaneous HST FUV Images
Authors: Louis C. K. , Prangé R. , Lamy L. , Zarka P. , Imai M. , Kurth W. S. , Connerney J. E. P. 
Published: October 2019

AbstractSince the discovery of Jovian auroral radio emissions, the question arises of the source positions of the different components (broadband kilometric, hectometric, and decametric) and their association with far ultraviolet (FUV) auroral emissions. We surveyed Juno's first 15 perijoves to track local radio sources from in situ Juno/Waves measurements (50 Hz to 40 MHz). This allowed us to study the 3‐D spatial distribution of the broadband kilometric, hectometric, and decametric radio sources. These sources are carried by the same magnetic field lines, with the bulk of them at apex M ranging from 15 to 60 (distance measured in RJ at the magnetic equator). Finally, comparisons with images of the Jovian FUV aurorae simultaneously acquired by the Hubble Space Telescope (HST) reveal a partial spatial colocation of the FUV main oval emission with the identified local radio sources.
Particle‐in‐cell Experiments Examine Electron Diffusion by Whistler‐mode Waves: 1. Benchmarking With a Cold Plasma
Authors: Allanson O. , Watt C. E. J. , Ratcliffe H. , Meredith N. P. , Allison H. J. , Bentley S. N. , Bloch T. , Glauert S. A. 
Published: October 2019

AbstractUsing a particle‐in‐cell code, we study the diffusive response of electrons due to wave‐particle interactions with whistler‐mode waves. The relatively simple configuration of field‐aligned waves in a cold plasma is used in order to benchmark our novel method, and to compare with previous works that used a different modelling technique. In this boundary‐value problem, incoherent whistler‐mode waves are excited at the domain boundary, and then propagate through the ambient plasma. Electron diffusion characteristics are directly extracted from particle data across all available energy and pitch‐angle space. The ‘nature’ of the diffusive response is itself a function of energy and pitch‐angle, such that the rate of diffusion is not always constant in time. However, after an initial transient phase, the rate of diffusion tends to a constant, in a manner that is consistent with the assumptions of quasilinear diffusion theory. This work establishes a framework for future investigations on the nature of diffusion due to whistler‐mode wave‐particle interactions, using particle‐in‐cell numerical codes with driven waves as boundary value problems.
Stable aerobic and anaerobic coexistence in anoxic marine zones
Authors: Zakem Emily J , Mahadevan Amala , Lauderdale Jonathan M , Follows Michael J 
Published: October 2019

Abstract
Mechanistic description of the transition from aerobic to anaerobic metabolism is necessary for diagnostic and predictive modeling of fixed nitrogen loss in anoxic marine zones (AMZs). In a metabolic model where diverse oxygen- and nitrogen-cycling microbial metabolisms are described by underlying redox chemical reactions, we predict a transition from strictly aerobic to predominantly anaerobic regimes as the outcome of ecological interactions along an oxygen gradient, obviating the need for prescribed critical oxygen concentrations. Competing aerobic and anaerobic metabolisms can coexist in anoxic conditions whether these metabolisms represent obligate or facultative populations. In the coexistence regime, relative rates of aerobic and anaerobic activity are determined by the ratio of oxygen to electron donor supply. The model simulates key characteristics of AMZs, such as the accumulation of nitrite and the sustainability of anammox at higher oxygen concentrations than denitrification, and articulates how microbial biomass concentrations relate to associated water column transformation rates as a function of redox stoichiometry and energetics. Incorporating the metabolic model into an idealized two-dimensional ocean circulation results in a simulated AMZ, in which a secondary chlorophyll maximum emerges from oxygen-limited grazing, and where vertical mixing and dispersal in the oxycline also contribute to metabolic co-occurrence. The modeling approach is mechanistic yet computationally economical and suitable for global change applications.
A genomics approach reveals the global genetic polymorphism, structure, and functional diversity of ten accessions of the marine model diatom Phaeodactylum tricornutum
Authors: Rastogi Achal , Vieira Fabio Rocha Jimenez , Deton-Cabanillas Anne-Flore , Veluchamy Alaguraj , Cantrel Catherine , Wang Gaohong , Vanormelingen Pieter , Bowler Chris , Piganeau Gwenael , Hu Hanhua , Tirichine Leila 
Published: October 2019

Abstract
Diatoms emerged in the Mesozoic period and presently constitute one of the main primary producers in the world’s ocean and are of a major economic importance. In the current study, using whole genome sequencing of ten accessions of the model diatom Phaeodactylum tricornutum, sampled at broad geospatial and temporal scales, we draw a comprehensive landscape of the genomic diversity within the species. We describe strong genetic subdivisions of the accessions into four genetic clades (A–D) with constituent populations of each clade possessing a conserved genetic and functional makeup, likely a consequence of the limited dispersal of P. tricornutum in the open ocean. We further suggest dominance of asexual reproduction across all the populations, as implied by high linkage disequilibrium. Finally, we show limited yet compelling signatures of genetic and functional convergence inducing changes in the selection pressure on many genes and metabolic pathways. We propose these findings to have significant implications for understanding the genetic structure of diatom populations in nature and provide a framework to assess the genomic underpinnings of their ecological success and impact on aquatic ecosystems where they play a major role. Our work provides valuable resources for functional genomics and for exploiting the biotechnological potential of this model diatom species.
Desipramine restores the alterations in circadian entrainment induced by prenatal exposure to glucocorticoids
Authors: Spulber Stefan , Conti Mirko , Elberling Frederik , Raciti Marilena , Borroto-Escuela Dasiel Oscar , Fuxe Kjell , Ceccatelli Sandra 
Published: October 2019

AbstractAlterations in circadian rhythms are closely linked to depression, and we have shown earlier that progressive alterations in circadian entrainment precede the onset of depression in mice exposed in utero to excess glucocorticoids. The aim of this study was to investigate whether treatment with the noradrenaline reuptake inhibitor desipramine (DMI) could restore the alterations in circadian entrainment and prevent the onset of depression-like behavior. C57Bl/6 mice were exposed to dexamethasone (DEX—synthetic glucocorticoid analog, 0.05 mg/kg/day) between gestational day 14 and delivery. Male offspring aged 6 months (mo) were treated with DMI (10 mg/kg/day in drinking water) for at least 21 days before behavioral testing. We recorded spontaneous activity using the TraffiCage™ system and found that DEX mice re-entrained faster than controls after an abrupt advance in light-dark cycle by 6 h, while DMI treatment significantly delayed re-entrainment. Next we assessed the synchronization of peripheral oscillators with the central clock (located in the suprachiasmatic nucleus—SCN), as well as the mechanisms required for entrainment. We found that photic entrainment of the SCN was apparently preserved in DEX mice, but the expression of clock genes in the hippocampus was not synchronized with the light-dark cycle. This was associated with downregulated mRNA expression for arginine vasopressin (AVP; the main molecular output entraining peripheral clocks) in the SCN, and for glucocorticoid receptor (GR; required for the negative feedback loop regulating glucocorticoid secretion) in the hippocampus. DMI treatment restored the mRNA expression of AVP in the SCN and enhanced GR-mediated signaling by upregulating GR expression and nuclear translocation in the hippocampus. Furthermore, DMI treatment at 6 mo prevented the onset of depression-like behavior and the associated alterations in neurogenesis in 12-mo-old DEX mice. Taken together, our data indicate that DMI treatment enhances GR-mediated signaling and restores the synchronization of peripheral clocks with the SCN and support the hypothesis that altered circadian entrainment is a modifiable risk factor for depression.
Interplay between Caspase 9 and X-linked Inhibitor of Apoptosis Protein (XIAP) in the oocyte elimination during fetal mouse development
Authors: Liu Xueqing , Castle Veronica , Taketo Teruko 
Published: October 2019

AbstractMammalian female fertility is limited by the number and quality of oocytes in the ovarian reserve. The number of oocytes is finite since all germ cells cease proliferation to become oocytes in fetal life. Moreover, 70–80% of the initial oocyte population is eliminated during fetal and neonatal development, restricting the ovarian reserve. Why so many oocytes are lost during normal development remains an enigma. In Meiotic Prophase I (MPI), oocytes go through homologous chromosome synapsis and recombination, dependent on formation and subsequent repair of DNA double strand breaks (DSBs). The oocytes that have failed in DSB repair or synapsis get eliminated mainly in neonatal ovaries. However, a large oocyte population is eliminated before birth, and the cause or mechanism of this early oocyte loss is not well understood. In the current paper, we show that the oocyte loss in fetal ovaries was prevented by a deficiency of Caspase 9 (CASP9), which is the hub of the mitochondrial apoptotic pathway. Furthermore, CASP9 and its downstream effector Caspase 3 were counteracted by endogenous X-linked Inhibitor of Apoptosis (XIAP) to regulate the oocyte population; while XIAP overexpression mimicked CASP9 deficiency, XIAP deficiency accelerated oocyte loss. In the CASP9 deficiency, more oocytes were accumulated at the pachytene stage with multiple γH2AFX foci and high LINE1 expression levels, but with normal levels of synapsis and overall DSB repair. We conclude that the oocytes with LINE1 overexpression were preferentially eliminated by CASP9-dependent apoptosis in balance with XIAP during fetal ovarian development. When such oocytes were retained, however, they get eliminated by a CASP9-independent mechanism during neonatal development. Thus, the oocyte is equipped with multiple surveillance mechanisms during MPI progression to safe-guard the quality of oocytes in the ovarian reserve.
Dual self-assembly of supramolecular peptide nanotubes to provide stabilisation in water
Authors: Rho Julia Y. , Cox Henry , Mansfield Edward D. H. , Ellacott Sean H. , Peltier Raoul , Brendel Johannes C. , Hartlieb Matthias , Waigh Thomas A. , Perrier Sébastien 
Published: October 2019

AbstractSelf-assembling peptides have the ability to spontaneously aggregate into large ordered structures. The reversibility of the peptide hydrogen bonded supramolecular assembly make them tunable to a host of different applications, although it leaves them highly dynamic and prone to disassembly at the low concentration needed for biological applications. Here we demonstrate that a secondary hydrophobic interaction, near the peptide core, can stabilise the highly dynamic peptide bonds, without losing the vital solubility of the systems in aqueous conditions. This hierarchical self-assembly process can be used to stabilise a range of different β-sheet hydrogen bonded architectures.
Effect of Gold Nanoparticle Size on Their Properties as Contrast Agents for Computed Tomography
Authors: Dong Yuxi C. , Hajfathalian Maryam , Maidment Portia S. N. , Hsu Jessica C. , Naha Pratap C. , Si-Mohamed Salim , Breuilly Marine , Kim Johoon , Chhour Peter , Douek Philippe , Litt Harold I. , Cormode David P. 
Published: October 2019

AbstractComputed tomography (CT) is one of the most commonly used clinical imaging modalities. There have recently been many reports of novel contrast agents for CT imaging. In particular, the development of gold nanoparticles (AuNP) as CT contrast agents is a topic of intense interest. AuNP have favorable characteristics for this application such as high payloads of contrast generating material, strong X-ray attenuation, excellent biocompatibility, tailorable surface chemistry, and tunable sizes and shapes. However, there have been conflicting reports on the role of AuNP size on their contrast generation for CT. We therefore sought to extensively investigate the AuNP size-CT contrast relationship. In order to do this, we synthesized AuNP with sizes ranging from 4 to 152 nm and capped them with 5 kDa m-PEG. The contrast generation of AuNP of different sizes was investigated with three clinical CT, a spectral photon counting CT (SPCCT) and two micro CT systems. X-ray attenuation was quantified as attenuation rate in Hounsfield units per unit concentration (HU/mM). No statistically significant difference in CT contrast generation was found among different AuNP sizes via phantom imaging with any of the systems tested. Furthermore, in vivo imaging was performed in mice to provide insight into the effect of AuNP size on animal biodistribution at CT dose levels, which has not previously been explored. Both in vivo imaging and ex vivo analysis with inductively coupled plasma optical emission spectroscopy (ICP-OES) indicated that AuNP that are 15 nm or smaller have long blood circulation times, while larger AuNP accumulated in the liver and spleen more rapidly. Therefore, while we observed no AuNP size effect on CT contrast generation, there is a significant effect of size on AuNP diagnostic utility.