bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sharp coefficient bounds for starlike functions associated with the Bell numbers
Authors: Kumar Virendra , Cho Nak Eun , Ravichandran V. , Srivastava H. M. 
Published: October 2019

Abstract
Let
$\begin{array}{}
\mathcal{S}^*_B
\end{array}$ be the class of normalized starlike functions associated with a function related to the Bell numbers. By establishing bounds on some coefficient functionals for the family of functions with positive real part, we derive for functions in the class
$\begin{array}{}
\mathcal{S}^*_B
\end{array}$ several sharp coefficient bounds on the first six coefficients and also further sharp bounds on the corresponding Hankel determinants. Bounds on the first three consecutive higher-order Schwarzian derivatives for functions in the class
$\begin{array}{}
\mathcal{S}^*_B
\end{array}$ are investigated.
Crop growth and viability of seeds on Mars and Moon soil simulants
Authors: Wamelink G.W.W. , Frissel J.Y. , Krijnen W.H.J. , Verwoert M.R. 
Published: October 2019

Abstract
If humans are going to establish a base on the Moon or on Mars they will have to grow their own crops. An option is to use Lunar and Martian regolith. These regoliths are not available for plant growth experiments, therefore NASA has developed regolith simulants. The major goal of this project was to cultivate and harvest crops on these Mars and Moon simulants. The simulants were mixed with organic matter to mimic the addition of residues from earlier harvests. Ten different crops, garden cress, rocket, tomato, radish, rye, quinoa, spinach, chives, pea and leek were sown in random lines in trays. Nine of the ten species grew well with the exception of spinach. It was possible to harvest edible parts for nine out of ten crops. The total biomass production per tray was highest for the Earth control and Mars soil simulant and differed significantly from Moon soil simulant. The seeds produced by three species were tested for germination (radish, rye and cress). The germination on Moon soil simulant was significantly lower in radish than for the Earth control soil.
The p75NTR Influences Cerebellar Circuit Development and Adult Behavior via Regulation of Cell Cycle Duration of Granule Cell Progenitors
Authors: Zanin Juan P. , Verpeut Jessica L. , Li Ying , Shiflett Michael W. , Wang Samuel S.-H. , Santhakumar Viji , Friedman Wilma J. 
Published: October 2019

Development of brain circuitry requires precise regulation and timing of proliferation and differentiation of neural progenitor cells. The p75 neurotrophin receptor (p75NTR) is highly expressed in the proliferating granule cell precursors (GCPs) during development of the cerebellum. In a previous paper, we showed that proNT3 promoted GCP cell cycle exit via p75NTR. Here we used genetically modified rats and mice of both sexes to show that p75NTR regulates the duration of the GCP cell cycle, requiring activation of RhoA. Rats and mice lacking p75NTR have dysregulated GCP proliferation, with deleterious effects on cerebellar circuit development and behavioral consequences persisting into adulthood. In the absence of p75NTR, the GCP cell cycle is accelerated, leading to delayed cell cycle exit, prolonged GCP proliferation, increased glutamatergic input to Purkinje cells, and a deficit in delay eyeblink conditioning, a cerebellum-dependent form of learning. These results demonstrate the necessity of appropriate developmental timing of the cell cycle for establishment of proper connectivity and associated behavior.SIGNIFICANCE STATEMENTThe cerebellum has been shown to be involved in numerous behaviors in addition to its classic association with motor function. Cerebellar function is disrupted in a variety of psychiatric disorders, including those on the autism spectrum. Here we show that the p75 neurotrophin receptor, which is abundantly expressed in the proliferating cerebellar granule cell progenitors, regulates the cell cycle of these progenitors. In the absence of this receptor, the cell cycle is dysregulated, leading to excessive progenitor proliferation, which alters the balance of inputs to Purkinje cells, disrupting the circuitry and leading to functional deficits that persist into adulthood.
Functional Localization of the Frontal Eye Fields in the Common Marmoset Using Microstimulation
Authors: Selvanayagam Janahan , Johnston Kevin D. , Schaeffer David J. , Hayrynen Lauren K. , Everling Stefan 
Published: October 2019

The frontal eye field (FEF) is a critical region for the deployment of overt and covert spatial attention. Although investigations in the macaque continue to provide insight into the neural underpinnings of the FEF, due to its location within a sulcus, the macaque FEF is virtually inaccessible to electrophysiological techniques such as high-density and laminar recordings. With a largely lissencephalic cortex, the common marmoset (Callithrix jacchus) is a promising alternative primate model for studying FEF microcircuitry. Putative homologies have been established with the macaque FEF on the basis of cytoarchitecture and connectivity; however, physiological investigation in awake, behaving marmosets is necessary to physiologically locate this area. Here, we addressed this gap using intracortical microstimulation in a broad range of frontal cortical areas in three adult marmosets (two males, one female). We implanted marmosets with 96-channel Utah arrays and applied microstimulation trains while they freely viewed video clips. We evoked short-latency fixed vector saccades at low currents (<50 μA) in areas 45, 8aV, 8C, and 6DR. We observed a topography of saccade direction and amplitude consistent with findings in macaques and humans: small saccades in ventrolateral FEF and large saccades combined with contralateral neck and shoulder movements encoded in dorsomedial FEF. Our data provide compelling evidence supporting homology between marmoset and macaque FEF and suggest that the marmoset is a useful primate model for investigating FEF microcircuitry and its contributions to oculomotor and cognitive functions.SIGNIFICANCE STATEMENTThe frontal eye field (FEF) is a critical cortical region for overt and covert spatial attention. The microcircuitry of this area remains poorly understood because in the macaque, the most commonly used model, it is embedded within a sulcus and is inaccessible to modern electrophysiological and imaging techniques. The common marmoset is a promising alternative primate model due to its lissencephalic cortex and potential for genetic manipulation. However, evidence for homologous cortical areas in this model remains limited and unclear. Here, we applied microstimulation in frontal cortical areas in marmosets to physiologically identify FEF. Our results provide compelling evidence for an FEF in the marmoset and suggest that the marmoset is a useful model for investigating FEF microcircuitry.
The Magnitude ofCandida albicansStress-Induced Genome Instability Results from an Interaction Between Ploidy and Antifungal Drugs
Authors: Avramovska Ognenka , Hickman Meleah A 
Published: October 2019

AbstractOrganismal ploidy and environmental stress impact the rates and types of mutational events. The opportunistic fungal pathogen Candida albicans, serves as a clinically relevant model for studying the interaction between eukaryotic ploidy and drug-induced mutagenesis. In this study, we compared the rates and types of genome perturbations in diploid and tetraploid C. albicans following exposure to two different classes of antifungal drugs; azoles and echinocandins. We measured mutations at three different scales: point mutation, loss-of-heterozygosity (LOH), and total DNA content for cells exposed to fluconazole and caspofungin. We found that caspofungin induced higher mutation rates than fluconazole, although this is likely an indirect consequence of stress-associated cell wall perturbations, rather than an inherent genotoxicity. Surprisingly, we found that antifungal drugs disproportionately elevated genome and ploidy instability in tetraploid C. albicans compared to diploids. Taken together, our results suggest that the magnitude of stress-induced mutagenesis results from an interaction between ploidy and antifungal drugs. These findings have both clinical and evolutionary implications for how fungal pathogens generate mutations in response to antifungal drug stress and how these mutations may facilitate the emergence of drug resistance.
Scalable Nonparametric Prescreening Method for Searching Higher-Order Genetic Interactions Underlying Quantitative Traits
Authors: Kontio Juho A J , Sillanpää Mikko J 
Published: October 2019

Abstract
The Gaussian process (GP) regression is theoretically capable of capturing higher-order gene-by-gene interactions important to trait variation non-exhaustively with high accuracy. Unfortunately, GP approach is scalable only for 100-200 genes and thus, not applicable for high...
Gaussian process (GP)-based automatic relevance determination (ARD) is known to be an efficient technique for identifying determinants of gene-by-gene interactions important to trait variation. However, the estimation of GP models is feasible only for low-dimensional datasets (∼200 variables), which severely limits application of the GP-based ARD method for high-throughput sequencing data. In this paper, we provide a nonparametric prescreening method that preserves virtually all the major benefits of the GP-based ARD method and extends its scalability to the typical high-dimensional datasets used in practice. In several simulated test scenarios, the proposed method compared favorably with existing nonparametric dimension reduction/prescreening methods suitable for higher-order interaction searches. As a real-data example, the proposed method was applied to a high-throughput dataset downloaded from the cancer genome atlas (TCGA) with measured expression levels of 16,976 genes (after preprocessing) from patients diagnosed with acute myeloid leukemia.
Adverse Effects of Transaction Costs in East European Economies
Authors: Todorova Tamara 
Published: October 2019

Abstract. At a given level of technology the gross aggregate production function lies above the net aggregate production function where the difference represents the aggregate transaction costs in the economy. Transitional economies facing serious institutional impediments to creating a smoothly functioning market mechanism are faced with sizable transaction costs. We use a net production function model enhanced by Furubotn and Richter and apply it conceptually to the case of transitional economies. We find that at a particular level of a community isoprofit line much less output will be supplied compared to developed market economies with mature market institutions. The aim of the paper is to trace the falling output and the deep structural problems of East European economies to the effect of transaction costs and institutional building. The more rapidly transaction costs grow, the less the firms would be willing to pay for inputs. Furthermore, we find that certain markets tend to disappear in emerging economies due to the adverse effects of transaction costs. As a safeguard to precontractual opportunism and prevention to ex post transaction costs, ex ante transaction costs would play a more vital role in East European societies.
Cultural Aspects of Compulsive Buying in Emerging and Developed Economies: a Cross Cultural Study in Compulsive Buying
Authors: Horváth Csilla , Adigüzel Feray , Herk Hester Van 
Published: October 2019

Although several studies focused on understanding of compulsive buying in developed countries, this phenomenon remains understudied in other parts of the world. This is rather surprising since there is an increasing interest in understanding shopping behavior of consumers in emergent markets due to the growing importance of these markets. The main reason for the limited attention to compulsive buying in emerging countries is the lack of cross-culturally validated scales.
In response to these calls, this paper tests measurement invariance of two prominent compulsive buying scales – the Compulsive Buying Scale (CBS) and the Compulsive Buying Index (CBI) in Western (Spain and the Netherlands) and emerging (Russia and Turkey) economies. In case of lack of invariance the reasons in terms of socio-cultural factors and country conditions are explained.
The results establish the partial measurement invariance of the CBI but not the CBS. So, to study the antecedents and consequences of compulsive buying in cross-cultural contexts, the CBI is sufficient. The varying credit card ownership and usage, and different gender roles of women across countries appear to be the main reasons for lack of measurement invariance of the CBS. The percentages of compulsive buyers in emerging countries are lower than those in developed countries.
AS OTHERS SEE THEMSELVES
Authors: P. A. G. S. 
Published: October 2019

"... We talk abut feeling liverish or having heartburn or chills on the kidney, but all these visceral images have to be invented, and our only source of information for the inventions is what we have been told. We reconstruct our insides from pictures in advertisements for patent medicines, from haif-remembered school science, from pieces of offal on butchers' slabs and all sorts of medical folklore.
These promptings may account for the otherwise inexplicable fact that the French seem to have far more trouble with their liver than the English do. It is hard to believe that this organ is so much more threatened in France than it is in England, in spite of what we have been told about their drinking habits. It seems more reasonable to assume that the French interpret their symptoms in the light of a national fantasy about the liver and unconsciously reshape their sensations in terms of this phantom organ. The English, on the other hand, are obsessed with their bowels. When an Englishman complains about constipation, you never know whether he is talking about his regularity, his lassitude, his headaches, or his depression. Once an organ gains a hold on the collective imagination, its influence is almost invariably exaggerated and a wide range of symptoms are explained in terms of it."
Erythema Following Transcutaneous Po2 Monitoring
Authors: Boyle Robert J. , Oh William 
Published: October 2019

Transcutaneous Po2 (tcPo2) monitoring has become a reliable adjunct in the care of the critically ill neonate.1 The heated electrode applied to the skin produces local hyperthermia and vasodilation, "arterializing" the capillary bed under the electrode. Huch et al1 have noted no skin damage or irritation from hyperthermia for up to seven hours of application. However, others have noted lesions ranging from slight erythema to small vesicles, persisting from several hours to several days.2-4 Bossi et al5 noted erythema disappearing within 24 hours in every patient.
To define the incidence and severity of these lesions we prospectively studied this aspect in infants undergoing tcPo2 monitoring.
Leprosy in a Vietnamese Adoptee
Authors: Lauer Brian A. , Lilla James A. , Golitz Loren E. 
Published: October 2019

The arrival in the United States of large numbers of Vietnamese war orphans and refugees means that physicians in this country may encounter exotic diseases that they have not been trained to recognize. We report here the case of a 10-year-old Vietnamese adoptee with tuberculoid leprosy. (This case was described in a brief letter to the editor, Pediatrics 61:330, 1978.) Our purpose is to remind physicians that leprosy is a common infection in Vietnam and that clinical symptoms may not appear for several years because of the long incubation period.
CASE HISTORY
A 10-year-old girl was seen in March 1977 because of a swollen finger and a tender mass in her palm.
Amniotic Fluid Microviscosity and Middle Ear Effusion
Authors: Jaffe Burton F. 
Published: October 2019

As an otologist interested in newborn ear disease, I was fascinated by the article in Pediatrics 63:213, 1979, entitled "Amniotic Fluid Microviscosity Determined by Fluorescence Polarization: Methodology and Relation to Gestational Age." It documented the decreasing viscosity of amniotic fluid as the fetus approached term delivery.
My experience with middle ear effusions in infants leads me to go one step further than the authors' presentation. I would like to suggest that in premature infants persistent middle ear fluid may very well be initiated by the higher viscosity of amniotic fluid. The study that leads me to this conclusion was conducted in 1967 by Jaffe et al.1
Impact of Neonatal Intensive Care on Neonatal Mortality in Chile
Authors: Ventura-Junca P. , Tapia J. L. , Winter A. , Gonzalez H. , Ciriano A. , Juez G. 
Published: October 2019

Up to the year 1975, neonatal care in our unit consisted of: pediatricians and nurses without specialization in neonatology; equipment basically limited to incubators; and treatment of premature infants and neonates with respiratory problems reduced to: (1) temperature control, (2) prevention of infection, (3) careful feeding and fluid administration, (4) oxygen therapy based on clinical appearance of cyanosis, and (5) correction of acidosis with NaHCO3.
See table in the PDF file
In 1976, a plan for introducing intensive care was begun.
Measles Vaccine in Egg-Allergic Children
Authors: Nieburg Phillip I. , Preblud Stephen R. , Halsey Neal A. , Brandling-Bennett A. David , Hinman Alan R. 
Published: October 2019

The question of allergy to eggs or chickens as a true contraindication to measles vaccination has recently been discussed.1,2 We would like to comment further on the issues involved.
Package inserts of vaccines have traditionally listed as contraindications allergies to the animal or egg whose cells have been used for propagating the virus in question. Measles vaccine in use now is produced in chick fibroblast cultures.3 This tissue differs from the egg cells that were used to grow viruses for some older vaccines and that are still used for influenza, yellow fever, and rabies vaccines.
Waardenburg Syndrome Associated with Hirschsprung Disease and Other Abnormalities
Authors: de Lumley Woodyear Lionel , Boulesteix Jean , Rutkowski Janice , Umdenstock Robert 
Published: October 2019

Upon reading the interesting article by Branski et al1 concerning Hirschsprung's disease and Waardenburg syndrome, we think it beneficial to report this association in one of our patients. As Branski et al pointed out, both conditions are believed to be caused by a defect in the migration of neural crest cells before the 12th week of gestation (a hypothesis elicited by McKusick2 in 1973).
Our patient, FD, was born at 41 weeks' gestation with a birth weight of 3,225 gm following an uncomplicated pregnancy.
KONSEP TASAWUF SYAIKH NAWAWI AL-BANTANI DAN IMPLIKASINYA TERHADAP PENDIDIKAN AGAMA ISLAM DI PERSEKOLAHAN
Authors: Hidayatulloh Muhammad Ridwan , Kosasih Aceng , Fahrudin Fahrudin 
Published: October 2019

Di era modern yang hampir runtuh ini, masih banyak manusia yang menegasikan unsur spiritual, sehingga terjadi dekadensi moral. Fenomena tersebut harus diantisipasi oleh umat Islam dengan menggali kembali ajaran spiritual dan mengaplikasikannya di kehidupan sehari-hari. Dalam agama Islam terdapat ajaran yang sangat menanamkan unsur spirtual dan manajemen hati, yaitu tasawuf. Di antara berbagai tokoh yang menyebarkan pemahaman tentang tasawuf, Syaikh Nawawi Al-Bantani menggambarkan tasawuf yang terintegrasi dalam setiap ibadah dan aktivitas muslim. Penelitian ini bertujuan untuk mendeskripsikan konsep tasawuf Syaikh Nawawi Al-Bantani dan implikasinya terhadap Pendidikan Agama Islam di persekolahan. Penelitian ini menggunakan pen-dekatan kualitatif dengan metode deskriptif. Pertimbangan penggunaan metode ini adalah untuk mengung-kap konsep tawasuf Syaikh Nawawi Al-Bantani dari berbagai karyanya, dan bagaimana implikasinya terha-dap Pendidikan Agama Islam di persekolahan. Dalam pengumpulan data peneliti menggunakan teknik studi literatur dan library research. Berdasarkan hasil penelitian diperoleh gambaran mengenai tasawuf Syaikh Nawawi Al-Bantani yang mengintergrasikan antara syariat, tarekat dan hakikat, serta wasiat-wasiat Syaikh Nawawi kepada setiap muslim yang hendak menempuh jalan menuju Allah. Konsep ini terimplikasi dalam Pendidikan Agama Islam yang harus menyeimbangkan antara ketiga aspek, yaitu Aqidah, Syariah, dan Akhlak, serta mengintegrasikan antara aspek kognitif, afektif, dan psikomotor
Las concepciones de ambiente inciden en el modelo de enseñanza de la educación ambiental
Authors: Quintero Mariana , Solarte María Claudia 
Published: October 2019

El artículo presenta el trabajo realizado en torno a la identificación de un modelo de educación ambiental a partir de la observación y análisis de prácticas de enseñanza de educación ambiental obtenidas como resultado de un estudio de caso. La hipótesis que se sostiene a lo largo de la investigación indica que las actividades de enseñanza en educación ambiental son producto de la concepción que se tiene del ambiente en el contexto estudiado. Para dar respuesta a la hipótesis se realizó el análisis de las prácticas de enseñanza de una maestra, a partir de la aplicación y análisis de instrumentos cualitativos; posteriormente se trianguló la información obtenida para identificar su modelo de enseñanza. Los resultados del estudio revelaron que el modelo de enseñanza de la maestra es sistémico, pues implementa varias actividades y a través de ellas establece relaciones entre diversos componentes del ambiente, y antropocéntrico, en tanto que considera que uno de sus compromisos en la enseñanza es la protección de la naturaleza. Lo anterior permitió demostrar la hipótesis de trabajo, a saber, que los modelos identificados coinciden con la concepción de ambiente y de educación ambiental de la maestra.
Studi Potensi Pembangkit Listrik Tenaga Mikro Hidro (PLTMH) Di Aliran Sungai Desa Kejawar Banyumas
Authors: Harto Jawadz Unggah Rizki , Prasetijo Hari , Purnomo Widhiatmoko Herry 
Published: October 2019

<span>Desa Kejawar memiliki sumberdaya air yang dapat dimanfaatkan sebagai pembangkit listrik tenaga mikro <span>hidro (PLTMH). Ketersediaan mercu bendung saluran pembawa, dan bak pengendap menjadi faktor utama diadakannya <span>penelitian ini. Metode yang digunakan dalam pengumpulan data primer berupa <span><em>head </em><span>yaitu dengan pengukuran langsung <span>di lokasi perencanaan pembangunan PLTMH dan didapatkan hasil pengukuran <span><em>head </em><span>efektif setinggi 3,08m. <span>Pengumpulan data sekunder berupa curah hujan, iklim, dan DAS sebagai perhitungan untuk debit andalan diperoleh <span>hasil 0,05 𝑚<span>3<span>/𝑠. Kapasitas daya dalam perencanaan pembangunan PLTMH ini sebesar 1,36 kW. Berdasarkan simulasi <span>menggunakan aplikasi TURBNPRO 3.0 turbin yang digunakan bertipe kincir dan alternator 3 kW. Total investasi yang <span>dibutuhkan dalam perencanaan pembangunan PLTMH sebesar Rp. 31.699.531 dengan umur proyek selama 10 tahun. <span>Kelayakan proyek perencanaan pembangunan PLTMH diperoleh nilai NPV pada <span><em>discount factor </em><span>10% sebesar Rp. <span>37.063.244&gt;0, BCR sebesar 2,1&gt;1, PP selama 3,46 tahun &lt; 10 tahun, IRR pada <span><em>discount factor </em><span>34% sebesar 33,6%. <span>Berdasar pada evaluasi proyek, dapat dikatakan perencanaan pembangunan PLTMH di aliran sungai Desa Kejawar <span>layak dilakukan</span></span></span></span></span></span></span></span></span></span></span><br /></span></span></span></span></span></span></span></span></span></span></span>