bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-management support? Listening to people with complex co-morbidities
Authors: Francis Helen , Carryer Jenny , Wilkinson Jill 
Published: September 2018

Objectives The study aimed to explore how people with complex, established co-morbidities experience long-term condition care in New Zealand. Despite the original conception as appropriate for people with early stage disease, in New Zealand the self-management approach dominates the care provided to people at all stages of diagnosis with long-term conditions, something reinforced through particular funding mechanisms. Methods A multiple case study followed the lives of 16 people with several long-term conditions. Data collection comprised two interviews, four weekly contacts with patients over an 18-month period and an interview with their primary health care clinicians. Results This paper reveals a cohort of tired, distracted patients struggling to manage their lives in the face of multiple conflicting challenges, with insufficient energy for the level of personal agency required to deal with the self-management approach. Discussion Participants described aspects of care received, which does meet their needs but sit outside the self-management approach, that resonate with the ideas behind current approaches to palliative care. The potential of an approach to care built upon these ideas is explored as a more compassionate, effective way of meeting the needs of people with advanced, multiple long-term conditions. Further research is warranted to explore the acceptability of such an approach.
Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway
Authors: Li Xiao-Qian , Yu Qian , Chen Feng-Shou , Tan Wen-Fei , Zhang Zai-Li , Ma Hong 
Published: September 2018

Abstract
Background
Ischaemia reperfusion (IR) induces multiple pathophysiological changes. In addition to its classical role in regulating tumourigenesis, the feedback loop formed by p53 and its driven target p53-upregulated modulator of apoptosis (PUMA) was recently demonstrated to be the common node tightly controlling various cellular responses during myocardial IR. However, the roles of the p53-PUMA feedback loop in the spinal cord remain unclear. This study aimed to elucidate the roles of p53-PUMA feedback interactions in the spinal cord after IR, specifically investigating their regulation of caspase 3-mediated apoptosis and nuclear factor (NF)-κB-mediated cytokine release.

Methods
SD rats subjected to 12 min of aortic arch occlusion served as IR models. Neurological assessment as well as p53 and PUMA mRNA and protein expression analyses were performed at 12-h intervals during a 48-h reperfusion period. The cellular distributions of p53 and PUMA were determined via double immunofluorescence staining. The effects of the p53-PUMA feedback loop on modulating hind-limb function; the number of TUNEL-positive cells; and protein levels of caspase 3, NF-κB and cytokines interleukin (IL)-1β and tumour necrosis factor (TNF)-α, were evaluated by intrathecal treatment with PUMA-specific or scramble siRNA and pifithrin (PFT)-α. Blood-spinal cord barrier (BSCB) breakdown was examined by Evans blue (EB) extravasation and water content analyses.

Results
IR induced significant behavioural deficits as demonstrated by deceased Tarlov scores, which displayed trends opposite those of PUMA and p53 protein and mRNA expression. Upregulated PUMA and p53 fluorescent labels were widely distributed in neurons, astrocytes and microglia. Injecting si-PUMA and PFT-α exerted significant anti-apoptosis effects as shown by the reduced number of TUNEL-positive cells, nuclear abnormalities and cleaved caspase 3 levels at 48 h post-IR. Additionally, p53 colocalized with NF-κB within the cell. Similarly, injecting si-PUMA and PFT-α exerted anti-inflammatory effects as shown by the decreased NF-κB translocation and release of IL-1β and TNF-α. Additionally, injecting si-PUMA and PFT-α preserved the BSCB integrity as determined by decreased EB extravasation and spinal water content. However, injecting si-Con did not induce any of the abovementioned effects.

Conclusions
Inhibition of aberrant p53-PUMA feedback loop activation by intrathecal treatment with si-PUMA and PFT-α prevented IR-induced neuroapoptosis, inflammatory responses and BSCB breakdown by inactivating caspase 3-mediated apoptosis and NF-κB-mediated cytokine release.
Potensi beberapa Jenis Rumput Laut sebagai Bahan Pangan Fungsional, Sumber Pigmen dan Antioksidan Alami
Authors: Sanger Grace , Kaseger Bertie Elias , Rarung Lexy Karel , Damongilala Lena 
Published: September 2018

Rumput laut dan ekstraknya mengandung banyak senyawa kimia protektif yang berfungsi sebagai antioksidan, di antaranya senyawa fenol, dietary fiber, PUFA dan fotosintetik pigmen. Penelitian ini bertujuan untuk menentukan kandungan pigmen dan aktivitas antioksidan ekstrak rumput laut <em>Gracilaria salicornia, Turbinaria decurens</em> dan <em>Halimeda macroloba</em> yang diambil dari perairan Sulawesi Utara. Rumput laut diekstraksi menggunakan metode maserasi dengan pelarut aseton dan etanol. Analisis pada penelitian ini terdiri dari: klorofil a, klorofil b, total klorofil, klorofi C1+C2, fukoxantin, karotenoid, fikosianin dan fikoeritrin; kadar total fenol, aktivitas peredam radikal DPPH (1,1-diphenyl-2-picrylhydracyl) dan daya reduksi. Hasil analisis menunjukkan bahwa kandungan pigmen tertinggi adalah klorofil C1+C2 yang<br />terdapat pada ekstrak etanol <em>H. macroloba</em> (6,23016±0,12457 mg/g). Kadar total fenol tertinggi terdapat pada ekstrak aseton <em>G. salicornia</em> (72,224±6,01 µg GAE (Galic acid equivalent)/g. Aktivitas aktioksidan peredam radikal DPPH tertinggi adalah ekstrak etanol <em>T. decurens</em> (IC50 0,3033±0,023 mg/mL). Nilai daya reduksi tertinggi terdapat pada ekstrak aseton dan atanol H. macroloba dengan nilai masing-masing 0,248±0,014 dan 0,214±0,013 µM Fe2+/mg. Hal ini disimpulkan bahwa <em>G. salicornia</em>, <em>T. decurens</em> dekstrak dan H. macroloba dapat berfungsi sebagai pangan fungsional sumber pigmen dan antioksidan alami. <br /><br />
the Effect of Age and Height on Some Selected Physical Properties of Ethiopian Highland Bamboo (Yushania Alpina)
Authors: Girma Yohannis gebremariam , Assefa Dessie 
Published: September 2018

Ethiopian highland bamboo is a multipurpose and a fast growing plant that supports local livelihoods in many ways. It is a source of food, fodder, furniture, textile raw material, building material, industrial inputs, fuel and other purposes in Ethiopia. Physical properties are considered to be important factors in determining the suitability of bamboo for various applications. A sufficient knowledge of the physical properties of bamboo ensures safe design for materials used in service. In this study, Effects of age and height on the basic density, moisture content, wall thickness and culm diameter of Ethiopian highland bamboo (Yushinia alpina) were studied on 2, 3 and 4 years-old bamboo. The result of the study show that four years old bamboo had the highest moisture content and wall thickness and the lowest density and culm diameter. Density and culm diameter did not show significant difference between 2, 3, and 4 years of old bamboo. However, variation in moisture content and wall thickness were observed between the three age groups. Density had greatest in bottom and lowest, in the top. There is no variation of moisture content, wall thickness and culm diameter at different height positions (Bottom, Middle and Top).
O programa Mais Educação em Maringá: apontamentos iniciais da proposta burguesa de educação integral
Authors: Gomes Marco Antônio de Oliveira 
Published: September 2018

O presente artigo tem por objetivo identificar historicamente a construção das propostas de educação integral, suas respectivas matrizes e analisar as propostas em curso no município de Maringá. Trata-se de uma análise documental, bibliográfica e de levantamento de dados fundamentada no materialismo histórico e dialético, que se expressa na Pedagogia Histórico-Crítica. O artigo aponta para os limites das propostas em curso que incorporam ações marcadas pela descontinuidade com destaque para a redução da responsabilidade do Estado diante da educação básica. Palavras-chave: Programa Mais Educação. Tempo Integral. Educação integral.
O professor na primeira república no Pará: notas sobre seu papel e função na relação família x escola
Authors: Pantoja Suellem Martins , Damasceno Alberto 
Published: September 2018

Neste artigo, buscamos compreender a ideia disseminada sobre o professor no período da Primeira República, bem como sobre o papel que este exercia na relação entre a família e a escola a partir do Regulamento Escolar do Ensino Primário, do ano 1890, e dos artigos de H. de Sant’Anna na Revista de Educação e Ensino, que circulava no Pará em 1894. Ele resulta de uma pesquisa documental e bibliográfica, e analisa preliminarmente os preceitos que regulamentavam o ensino nesse período, que apontavam para a formação de cidadãos para o progresso da nação, funcionando a educação como um mecanismo de difusão do ideário republicano. Neste sentido, o professor não poderia se portar na escola e na sociedade como um “cidadão qualquer”, de modo que o Regulamento Escolar do Ensino Primário e os esritos de Sant’Anna chegam a explicitar regras de comportamento moral e social que ultrapassariam os limites da escola. Ao mestre, caberia a tarefa de ser um propagador e fiscalizador dos novos hábitos e regras no ambiente escolar, baseado no ideal de professor projetado pelo regulamento de ensino e pela imprensa educacional da época, que estava ligado a um projeto político — o de implementação do ideal republicano. Neste sentido, o professor era tido como um mestre da vida cidadã, titular de uma profissão tida e sabida como sacerdócio, cabendo-lhe forjar o futuro da nação brasileira, sobretudo cultivando nas crianças o sentimento de amor à pátria e à República. Palavras-chave: Primeira República. Família-escola. Professor. Ensino-primário.
Mapeamento das produções acadêmicas sobre condições de trabalho do coordenador pedagógico (2012 a 2016)
Authors: Oliveira Eliane Guimarães de , Nunes Claudio Pinto 
Published: September 2018

Este estudo faz parte da pesquisa em construção sobre as condições de trabalho do coordenador pedagógico e tem por objetivo apresentar um mapeamento das produções acadêmicas referentes a temática no recorte temporal de 2012 a 2016. Para realização do trabalho foi feita pesquisa no banco de teses e dissertações da Capes com o descritor: condições de trabalho do coordenador pedagógico, sendo localizado um total de 56 trabalhos, sendo 45 dissertações e 11 teses, estando o número maior de produções na região Sudeste. Na leitura dos títulos, resumos e palavras-chave, identificamos diversas nomenclaturas para o coordenador pedagógico e o principal conteúdo abordado nos trabalhos é a formação continuada. Somente uma dissertação trata de forma específica sobre as condições de trabalho do supervisor escolar, discutindo componentes como: forma de ingresso, jornada de trabalho, carreira e remuneração. Diante do mapeamento realizado, fica evidenciado a lacuna desse debate no campo de pesquisa e a necessidade de novos estudos. Palavras-chave: Condições de Trabalho. Coordenador Pedagógico. Produções Acadêmicas.
Descrição dos frutos nativos utilizados na alimentação do povo indígena Rikbaktsa
Authors: Utumy Edson , Leão Marcelo Franco 
Published: September 2018

Com o intuito de registrar os conhecimentos tradicionais e científicos sobre a alimentação do povo indígena Rikbaktsa, este estudo tem como objetivo descrever as características básicas dos frutos nativos utilizados na alimentação dos Rikbaktsa e a maneira como ocorre esse consumo. Trata-se de um estudo etnográfico, desenvolvido no período de 2014 a 2016, que envolveu as três Terras Indígenas: Erikpatsa, Japuíra e Escondido, localizadas nos municípios mato-grossenses de Brasnorte, Juara, Cotriguaçu, respectivamente. Os dados foram coletados por meio de entrevistas com os anciãos de diferentes comunidades, além das observações a campo sobre os frutos comestíveis disponíveis na região. Os frutos foram desenhados e posteriormente descritos quanto à época de colheita e a maneira como são consumidos. O estudo permitiu descrever 32 frutos nativos comestíveis do povo Rikbaktsa. Essa variedade encontrada pode estar relacionada ao fato de o território investigado comportar parte de cerrado, bem como possuir área de floresta amazônica. Foi possível identificar os nomes de cada fruto na língua materna, popular e científico e a sazonalidade desses frutos. Quanto à maneira de preparo, constatou-se que alguns deles servem para comer assim que retirado do pé, outros ficam guardados durante três ou mais dias a fim de amadurecer, outros são cozidos, outros servem para fazer suco ou chicha (bebida fermentada). O estudo permitiu registrar características dos frutos nativos é uma maneira de preservar a cultura e fortalecer os costumes para que não sejam esquecidos. Espera-se que esse artigo sirva como fonte de consulta às futuras gerações, indígenas e não indígenas. Palavras-chave: Alimentação. Modo de consumo. Povo tradicional.
Cenários e perspectivas de políticas públicas da educação especial no Brasil
Authors: Teixeira Ricardo Antonio Gonçalves , Oliveira Ana Flávia Teodoro de Mendonça , Sousa Andréia da Silva Quintanilha 
Published: September 2018

Este artigo está dividido em duas partes, no primeiro momento discute os aspectos históricos-normativos da educação especial no Brasil desde as primeiras iniciativas de institucionalização implementadas no período imperial até os dias atuais. No segundo momento, mapeia por meio de levantamento e da exploração dos dados extraídos do Censo escolar, INEP, de 1998 a 2016, o total de matrículas na educação especial em escolas especializadas e classes especiais, por etapas e modalidade de ensino. A pesquisa pode ser classificada como do tipo exploratória, cuja principal finalidade é proporcionar uma visão geral do cenário da educação especial no Brasil. As “fronteiras” de uma política pública são sempre suscetíveis de serem postas em questão, através de um processo constante de redefinição dos limites dos campos políticos e do contexto histórico de cada época, como nos alertam Muller e Surel (2001). Assim, para o século XXI, o atendimento às pessoas com deficiência é empreendido com base no novo modelo denominado inclusivo no qual a ideia defendida é a de que não é a pessoa com deficiência que deve se adaptar à escola, mas as instituições escolares que devem ser capazes de oferecer condições de acesso e permanência para todos. Palavras-chave: Políticas Públicas. Educação Especial. Matrículas.
Total Equitable Bondage Number of a Graph
Authors: Vaidya S. K. , Parmar A. D. 
Published: September 2018

If for any total dominating set D with ν ∈ V (G) − D there exists a vertex u ∈ D such that uν ∈ E (G) and |d(ν)−d(u)| ≤ 1 then D is called the total equitable dominating set. The minimum cardinality of the total equitable dominating set is called the total equitable domination number denoted by γet (G). The bondage number b(G) of a nonempty graph G is the minimum cardinality among all sets of edges E0 ⊆ E(G) for which γ(G – E0) > γ(G). We introduced the concept of total equitable bondage number and proved several results.
Thin Layer Chromatography-A Tool to Investigate Kinetics of Michael Addition Reaction
Authors: Susan M. A. B. H. , Ara G. , Islam M. M. , Rahman M. M. , Mollah M. Y. A. 
Published: September 2018

Thin layer chromatography (TLC), a tool for defining identity, purity, and quantitation of a compound, has also been proved useful for monitoring the progress of a chemical reaction. However, the technique is yet to be exploited for investigating the kinetics of a reaction systematically. In this work, we used TLC for measuring the time for consumption of a reactant in Michael addition reaction of acetylacetone with 2-cyclohexene-1-one. Average rate of the model reaction was determined using a definite initial concentration of acetylacetone for a series of catalyst systems like NaOH, 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), DBU based protic ionic liquids (PILs) 1,8-diazabicyclo[5.4.0]undec-7-ene-8-ium hydroxide ([HDBU]OH) and 1,8-diazabicyclo[5.4.0]undec-7-ene-8-ium acetate ([HDBU]CH3COO), a DBU based aprotic ionic liquid (AIL), 8-hexyl-1,8-diazabicyclo [5.4.0]undec-7-ene-8-ium hydroxide ([C6DBU]OH), and binary systems of the ionic liquids with molecular solvents, such as, water, DBU, and acetic acid. The kinetic data on the performance of the chosen catalysts were interpreted on the basis of the established mechanism of the reaction. Finally, the prospect of the method based on TLC as a suitable technique for kinetic study of chemical reactions has been discussed.
Incidence and Predictive Factors for Orthopedic Surgery in Patients with Psoriatic Arthritis
Authors: Nystad Tone Wikene , Husum Yngvil Solheim , Furnes Ove Nord , Fevang Bjørg-Tilde Svanes 
Published: September 2018

Objective.To investigate the incidence of orthopedic procedures in patients with psoriatic arthritis (PsA), and how patient characteristics, time of diagnosis, and treatment affect the need for surgery.Methods.We reviewed the medical history of 1432 patients with possible PsA at Haukeland University Hospital in Bergen, Norway. There were 590 patients (mean age 49 yrs, 52% women) who had sufficient journal information and a confirmed diagnosis of PsA, and who were included in the present study. Relevant orthopedic procedures were obtained from the hospital’s administrative patient records. Survival analyses were completed to evaluate the effect of different factors such as year of diagnosis, age, sex, radiographic changes, disease activity, and treatment, on the risk of surgery.Results.There were 171 procedures (25% synovectomies, 15% arthrodesis, and 53% prostheses) performed on 117 patients. These factors all increased the risk of surgery: female sex [relative risk (RR) 1.9, p = 0.001], age ≥ 70 years at diagnosis (RR 2.4, p = 0.001), arthritis in initial radiographs (RR 2.2, p = 0.006), and maximum erythrocyte sedimentation rate 30–59 mm/h (RR 1.6, p = 0.026). Time period of diagnosis had no effect on the outcome. In a subanalysis of surgery exclusive of hip and knee arthroplasty, diagnosis in earlier years (1954–1985 vs 1999–2011) was a risk factor (RR 2.1, p = 0.042). Antirheumatic treatment changed significantly over time.Conclusion.There were 20% of patients with PsA who needed surgery. We found that the prognosis of patients with PsA did not change regarding the risk of orthopedic surgery, despite the change in treatment. A possible explanation is the increase in large joint replacements in the general population.
Traduire le régionalisme : le destin américain des pièces de Reinhold Solger
Authors: Massnick Thomas O. 
Published: September 2018

Cet essai entend explorer les conséquences, politiques, génériques, du transfert d’une pièce régionaliste depuis l’Europe jusqu’en Amérique, à l’heure des Révolutions démocratiques du milieu du xix e siècle. Der Reichstags-Professor , farce locale écrite par Reinhold Solger (1817-1866), dramaturge et homme politique révolutionnaire, lors de son exil en Suisse, use de jeux de dialecte pour souligner des rapports de classe. The Hon. Anodyne Humdrum: or, The Union Must and Shall be Preserved , version anglaise de la pièce, n’en est pas seulement une traduction : le décor n’est plus le Berlin post-révolutionnaire mais la Virginie d’avant la guerre de Sécession, et le dialecte y prend une autre signification, départageant les races plus que les classes. Cet essai reconsidère donc le rôle de la traduction et de la politique des genres dans la relocalisation géo-politique de la pièce régionale.
Heimat en errance dans les Histoires villageoises de la Forêt-Noire de Berthold Auerbach
Authors: Gauthier Cécile 
Published: September 2018

La Heimat , dans le premier volume des Histoires villageoises de la Forêt-Noire (1843) de B. Auerbach, est plus globalisée que ne le laisserait penser son traditionnel ancrage dans le local : les mutations de la modernité ont atteint le village et la Heimat naît de la crainte de sa prochaine disparition. Ce qui émerge alors est une Heimat en errance, Heimat nomade, délocalisée voire relocalisable. Cet article étudie les mutations de l’expérience de la Heimat à travers deux histoires villageoises, et le parcours de deux personnages : Tolpatsch, qui émigre et réimplante son village souabe outre-mer, découvrant là-bas sa germanité tout en devenant progressivement américain ; et Ivo, double autobiographique de l’auteur, qui choisit le village d’à côté, signe, peut-être, d’une impossible Heimkehr , mais signe aussi d’une réinvention de la Heimat , et donc de soi, par l’expérience de l’écart.
« Je suis maîtrisé par mon imagination » : le cas Chénier
Authors: Genand Stéphanie 
Published: September 2018

La poésie d’André Chénier accorde une importance particulière à l’imagination : conçue comme une dépossession de soi, elle s’apparente, par sa violence et l’autonomie dont la dote le poète rendu passif par ses assauts, à une crise qui invalide la raison. Transport, élans, désorganisation des facultés, ses symptômes la rattachent à la folie qui s’empare des esprits au moment 1800 : de la recherche d’une syntaxe plus souple, capable d’épouser les élucubrations des âmes poétiques, à la vogue des « folles » au théâtre, en passant par les convulsions politiques qui égarent les contemporains, les signes abondent d’un dérèglement et d’une perte des repères au tournant du siècle. Chénier, pleinement inscrit dans ce contexte, y joue un rôle moteur en tendant le miroir de ses textes aux excès et aux stupeurs des imaginations, amoureuses, familiales ou politiques, qui nourrissent son inspiration. Et si son œuvre se voulait, par ses fractures et ses lacunes, la partition la plus à l’écoute des chants inquiétants qui surgissent autour de lui ?
Qu’est-ce qu’un doute raisonnable ?
Authors: Vorms Marion 
Published: September 2018

Un aspect particulier de l’irrationalité théorique concerne les croyances qu’il faudrait suspendre ou ne pas accepter : le doute raisonnable. Faute de pouvoir déterminer avec certitude ce qu’il est rationnel de croire en certaines circonstances, notamment lorsque, comme dans le cas d’un procès criminel, on ne peut avoir un accès direct ni garanti à la vérité, il est commun de recourir à un critère moins exigeant que celui de rationalité, à savoir celui du raisonnable, qui est d’essence politique et sociale, autant qu’épistémologique. Qu’est-ce qu’un doute raisonnable, tel qu’on l’entend dans la tradition juridique de la common law , et qu’est-ce qui fixe le seuil au-delà duquel le jury est autorisé à considérer que les preuves fournies établissent effectivement la culpabilité du prévenu ?
Recente ontwikkelingen in de rijksbrede wetgevingstoetsing
Authors: van Melis S.A.P.J. 
Published: September 2018

Recente ontwikkelingen in de rijksbrede wetgevingstoetsing
Iedereen wil betere kwaliteit van wetgeving, maar het daadwerkelijk realiseren hiervan is gemakkelijker gezegd dan gedaan. De rijksbrede wetgevingstoetsing, onder verantwoordelijkheid van het ministerie van Justitie en Veiligheid, levert hieraan op verschillende manieren een bijdrage. De auteur gaat in op de organisatie en meerwaarde van de rijksbrede wetgevingstoetsing en de dilemma’s die hierbij spelen. Ook komen de effecten van de toetsing aan de orde, de relatie met de Raad van State en de parlementaire aandacht voor wetgevingskwaliteit. Aan de hand van internationale ontwikkelingen worden verder te onderzoeken opties geschetst voor de toekomstige ontwikkeling van de rijksbrede wetgevingstoetsing.