bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kimliğin Etni ve Ulus Arasında Salınımı: Çokkültürcülük mü Yeniden Kabilecilik mi?
Authors: Konuralp Emrah 
Published: September 2018

Çeşitli
öğelerin bir araya gelmesiyle üretilen,
biçimlenen, değişen, dönüşen, yeniden üretilen etnik kimliği oluşturan öğelerin
başında gelen milliyet, ırk, sınıf, din, toplumsal cinsiyet ve dil kimliği oluştururken
genellikle iç içe geçer ve tikel bir etnik kimliğin tarihsel biçimleniş
koşulları dolayımıyla bu öğelerden hangisinin diğerlerine göre baskınlığı
değişkendir. Bu makalede kimlik kavramının öznel ve öznelerarası boyutlarından
hareketle etnisite-milliyet etkileşimi üzerinden çözümlemesi yapılmaktadır.
Tikelin evrenselle bağının koptuğu çokkültürcü paradigmanın kimlik
çatışmalarını çözmek bir yana demokratik toplumu temelsizleştirme tehlikesine
dikkat çekilirken yeniden kabileselleşme olarak adlandırılabilecek olan
kabileciliğe dönüş eğilimi ele alınmaktadır. Bu anlamda, çokkültürcülüğün
çelişkilerine işaret etmek adına bu makalenin temel amacı, akraba kavramlar
olan etni ve ulus ile etnisite ve
milliyetçilik arasındaki -parçalanmış toplumlara yol açan- ilişkileri ortaya
koymaktır.
Ventilator associated pneumonia: incidence, profile and outcome in pediatric intensive care unit of tertiary care centre
Authors: Gadappa Swati M. , Behera Manas Kumar 
Published: September 2018

Background: Ventilator-Associated Pneumonia (VAP) refers to nosocomial pneumonia occurring 48 hours or more after initiation of mechanical ventilation (MV), with frequencies ranging from 15-45%. The incidence rates of VAP are higher in developing countries with limited resources. Early and late VAP differ in their pathogenesis, micro-organisms responsible, antibiotic sensitivity, outcome and treatment.Methods: Retrospective cohort study of all critically ill children between 1 month to 12 years who were admitted and mechanically ventilated in our 8-bedded PICU between January 2015 to June 2016 and developed Ventilator associated pneumonia. PIM3 (Paediatric Index of Mortality 3) was calculated. We compared early and late VAP for risk factors, length of stay on mechanical ventilation (LOS MV) and outcome. The data collected were compiled and tabulated.Results: The incidence of VAP in this study was 40%. We found significant correlation between early and late VAP with parenteral nutrition (p = 0.001), presence of nasogastric tube (p = 0.012) and mortality (p = 0.027). The LOS MV was Mean 7.25 days in early VAP, while 22.75 days in late VAP; which demonstrated significant correlation (p = 0.003). There was no significant correlation of PIM3 with VAP, reintubation and mortality. Most frequent organisms found in Early VAP were Acinetobacter baumannii and MRSA, whereas in late VAP Pseudomonas aeruginosa was commonest isolated organism.Conclusions: VAP is a major cause of mortality in PICU. Late VAP was associated with longer length of stay on mechanical ventilation (LOS MV), higher mortality. This study thus emphasizes the need for prospective multicentric case-control studies for formulating and applying early preventive strategies in PICU to reduce VAP-related mortality.
'Niet weer Triëst'
Authors: Van Hout Milou 
Published: September 2018

‘Trieste, non di nuovo’In questo contributo ci si chiede come Trieste sia potuta crescere in modo tale da diventare una città dal significato mitologico letterario. Dal punto di vista della persona e dello scrittore Claudio Magris, vengono indagati l’ambiente letterario urbano di Trieste e la sua manifestazione in un discorso europeo di diversità ed identità durante periodi di crisi. Si propone una lettura di tale ambiente urbano come se fosse un mental mindscape in cui Trieste rappresenti sia un microcosmo in un contesto europeo che un’indicazione di luoghi concreti all’interno dello stesso spazio urbano.
On lattice ordered intuitionistic fuzzy soft sets
Authors: Mahmood Tahir , Ali Muhammad Irfan , Malik Muhammad Aamir , Ahmed Waseem 
Published: September 2018

Lattices, soft sets, fuzzy sets and their generalizations have always been important for Mathematicians and the researchers working on uncertaities. In this paper our aim is to introduce the concept of lattice ordered intuitionistic fuzzy soft sets. After introducing extended union, extended intersection, AND-product, OR-product, basic union, basic intersection of intuitionistic fuzzy soft sets, in this paper the affects of lattice ordered intuitionistic fuzzy soft sets and anti-lattice ordered intuitionistic fuzzy soft sets on restricted union, restricted intersection, extended union, extended intersection,AND-product, OR-product, basic union, basic intersection of intuitionistic fuzzy sets are discussed. Further a decision making problem is solved by using these concepts.
Generalization of (∈,∈∨q_k )-fuzzy subnear-rings and (∈,∈∨q_k )-fuzzy ideals of near-rings
Authors: Manikantan T. , Ramkumar S. 
Published: September 2018

In this paper, we introduce the notions of (∈, ∈∨q_δ^k)-fuzzy subnear-ring and (∈, ∈∨q_δ^k)-fuzzy ideal of a near-ring which are generalization of (∈, ∈∨q_k)-fuzzy subnear-ring and (∈, ∈∨q_k)-fuzzy ideal respectively. We provide the characterizations of (∈, ∈∨q_δ^k)-fuzzy subnear-ring (resp. ideal) of a near-ring and deal with some related properties. Further, we introduce the notion of ∈∨q_δ^k-level subset of a fuzzy subset and obtain some related results.
Parkinson Hastalığında D Vitamininin Etkisi: Güncel Yaklaşımlar
Authors: ERDEM Nur Bengü , AYAZ Aylin 
Published: September 2018

Bu
derleme yazıda Parkinson hastalığında D
vitaminin etkisini güncel çalışma sonuçlarına göre değerlendirmek
amaçlanmıştır.
A LINK BETWEEN AUTOPHAGY REGULATORY PROTEINS M-TOR AND BECLIN-1 AND PARAMETERS OF LYMPHOGENIC METASTASIS IN COLORECTAL CANCER
Authors: Vtorushin S. V. , Rachkovsky K. V. , Krakhmal N. V. , Stepanov I. V. , Zavyalova M. V. 
Published: September 2018

Currently the impact of autophagy on carcinogenesis remains understudied. On the one hand, autophagy acts as a tumor suppressor, as it activates degradation of oncoproteins, toxic proteins, and damaged cell organelles, that may be aggressive and lead to DNA damage. On the other hand, autophagy may promote tumor cell survival under hypoxia and in the presence of reactive oxygen species, which occurs primarily due to blocking of apoptosis mechanisms, raising the chances for maintaining tumor clone dynamics. Autophagy regulation is a complicated and multi-stage process. The main regulator here is a signaling pathway that activates serine/threonine protein kinase m-TOR (the mammalian target of rapamycin). Data on the impact of autophagic proteins ATG5, LC3A, LC3B, and Beclin-1 on malignant cell survival as well as on tumor growth and progression have been reported in literature. However, studies aimed at seeking possible relationships between autophagy and pathogenetic mechanisms of carcinogenesis are of great interest.Theaimof the study is to investigate a relationship between the expression parameters of autophagy regulatory proteins m-TOR and Beclin-1 and the features of lymphogenic metastasis in colorectal cancer.Materials and methods. The study included 105 patients with T1-4N0-3M0 colorectal cancer treated in the Thoracic and Abdominal Department of Cancer Research Institute of Tomsk Research Medical Center from 2012 to 2015. The average age of patients was 59.7±4.3 years. Morphological verification of the diagnosis was performed on the biopsy samples of primary tumor tissue. Staging of colorectal cancer was determined according to the TNM classification of malignant tumors (2002).Results.Analysis of the frequency of lymphogenic metastasis depending on the presence or absence of m-Tor and Beclin-1 expression in tumor cell cytoplasm revealed a statistically significant link between these variables.Conclusion.The obtained findings clearly exhibit that deceleration or loss of autophagic activity in the tumor is accompanied by implementation of lymphogenic dissemination, which is a predictor of an unfavorable outcome of the disease.
HEREDITARY DIFFUSE GASTRIC CANCER: GENETIC ASPECTS AND PROPHYLACTIC TOTAL GASTRECTOMY
Authors: Lyubchenko L. N. , Filippova M. G. , Anurova O. A. , Nazliev P. B. , Stilidi I. S. 
Published: September 2018

For patients with an identified germline E-cadherin-1 (CDH1) mutation, prophylactic gastrectomy is the treatment of choice to eliminate the high risk of developing diffuse gastric cancer. The case report describes a rare case of hereditary diffuse gastric cancer (HDGC) associated with CDH1 gene mutation, which is reported in the Russian population for the first time. In 2013, a 28-year- old woman was referred to Clinical Oncogenetics Laboratory with a family history of gastric cancer. Molecular genetic analysis revealed CDH1 gene mutation. The lifetime risk of cancer in mutation positive members is more than 80. Histological examination of gastric biopsy specimens obtained during endoscopy revealed isolated signet ring cells in the lamina propria. Spleenpreserving D2-lymphodissection and total gastrectomy with Roux-en-Y reconstruction with a jejunal reservoir formation were performed at the Abdominal Oncology Surgery Department.
THE FIRST EXPERIENCE OF USING 99MTC-1-THIO-D-GLUCOSE FOR SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY IMAGING OF LYMPHOMAS
Authors: Chernov V. I. , Dudnikova E. A. , Zelchan R. V. , Kravchuk T. L. , Danilova A. V. , Medvedeva A. A. , Sinilkin I. G. , Bragina O. D. , Goldberg V. E. , Goldberg A. V. , Frolova I. G. 
Published: September 2018

Introduction. The purpose of this study was to evaluate the feasibility of using 99mTc-TG SPECT in the detection and staging of malignant lymphoma.Materials and methods.Fifteen patients with newly diagnosed malignant lymphoma underwent 99mTc-TG SPECT. Six patients had Hodgkin’s lymphoma and 9 patients had aggressive forms of non-Hodgkin’s lymphoma (NHL): diffuse large B-cell lymphoma (7 cases), B-cell follicular lymphoma (1 case), and lymphoma from B cells in the marginal zone (1 case). Stage IIA was diagnosed in 5 patients, stage IIB in 1, stage IIIA in 1, stage IVA in 4 and stage IVB in 4 patients.Results.Pathological 99mTc-TG uptake in lymph nodes was observed in 14 (93 %) of the 15 patients. In one patient, the enlarged submandibular lymph node (16 mm in size) detected by CT was not visualized by 99mTc-TG SPECT. This false-negative result was likely to be associated with increased accumulation of 99mTc-TG in the oropharyngeal region. There were difficulties in the visualization of paratracheal, para-aortic and paracardial lymph nodes. These difficulties were associated with a high blood background activity, which persisted even 4 hours after intravenous injection of 99mTc-TG. Software-based SPECT and CT image fusion allowed visualization of these lymph nodes. The pathological 99mTc-TG accumulation in axillary, supraclavicular, infraclavicular and cervical lymph nodes was observed most often. Extranodal involvement was seen in 9 patients. 99mTc-TG SPECT identified extranodal hypermetabolic lesions in 7 (78 %) of these patients. In one patient, hypermetabolic lesion in the lung detected by 99mTc-TG SPECT was not detected on CT image. CT identified bone marrow involvement in the pelvic and scapula in 1 patient. The use of 99mTc-TG SPECT allowed the visualization of hypermetabolic bone tissue lesions in this patient (Figure 4). In addition, in a patient with intact bone tissue on CT, 99mTc-TG SPECT detected hypermetabolic lesions in the iliac bone.Conclusion.99mTc-1-Thio-D-glucose demonstrated increased uptake in nodal and extranodal sites of lymphoma. The results indicate that SPECT with 99mTc-1-Thio-D-glucose is a feasible and useful tool in the detection and staging malignant lymphoma.
Current Ventilation And Air Quality Problems Against Historical Solutions
Authors: RADZIEWICZ-WINNICKI Rafał 
Published: September 2018

Abstract
The paper describes the issue of ventilation and air quality in buildings with reference to regular tightening of heating standards. The purpose of the work is to show the risks related to excessive insulation of buildings, which is thought to have a negative influence on users’ well-being and health. The development of issues related to thermal comfort has often led to erroneous solutions. As a result, problems such as “Sick Building Syndrome” and “Building Related Illness” has developed in the recent history, whereas in the long history of the ‘art of construction’, there existed a number of solutions beneficial for users’ health. This issue serves as a pretext for the presentation of former solutions, gradually improved on the basis of the observation of nature, physical phenomena, predecessors’ experiences, creative thinking and intuition. They were used for ages and have become a basis for today’s architectural solutions, although some of them have been forgotten or eliminated by higher and higher normative requirements. In the paper, the author asks the following research question: Do modern legal instruments and standards provide an effective guarantee of high quality of internal air and heat comfort of buildings? Is there an alternative development path for these issues?
Students’ Needs and Vocabulary Development in English for Specific Purposes Course
Authors: LOW PIYADA 
Published: September 2018

<p><em>Vocabulary is very important for language learners. Limited knowledge of vocabulary can cause problems in language learning, especially in English for Specific Purposes (ESP). Students’ needs on English vocabulary should be invested for learning achievement. The research study was conducted with all students registering in an ESP course, English for Food and Beverage Service. The total number was 54 students: 48 females and 6 males. Three instruments were employed: first and post-activity questionnaires, task assignment, and a vocabulary test. The food lists in the questionnaires fall into five groups: herbs, spices, and food seasonings; vegetables; fruits; meat and poultry; fish and shellfish. Vocabulary list with more than 50% chosen as needed in each food group from the first questionnaire distributed at the beginning of the course were used to create a test on students’ vocabulary knowledge. Two most chosen food groups for vocabulary knowledge development were herbs, spices, and food seasonings group (98.1%) and fish and shell fish group (96.3%). Fish and shellfish list was the only group indicated as a very great problem for the students (48.1%). Vocabulary test results showed the lowest score of 0/23 while the highest score is 22/23 from fish and shellfish group list. </em><em>Mean of the fish and shellfish food list is 10.80 which is the lowest mean among the five group lists on the vocabulary test.</em><em> 63% of the students admitted that task assignment responded to their needs of English food vocabulary development.</em><em></em></p>
Imagen corporal, estrés percibido y resiliencia en militares amputados en el conflicto armado interno en Colombia
Authors: Herrera-Moreno Daniela , Carvajal-Ovalle Diego , Cueva-Nuñez Angélica , Acevedo Camila , Riveros Munévar Fernando , Camacho Katherin , Fajardo-Tejada Diana Milena , Clavijo-Moreno Mauricio Noel , Lara-Correa Dary Luz , Vinaccia Alpi Stefano 
Published: September 2018

El objetivo del presente estudio fue determinar los niveles y la relación entre satisfacción de la imagen corporal, estrés percibido y resiliencia en soldados con amputación víctimas del conflicto armado interno colombiano. Fue un estudio cuantitativo, transversal, de alcance correlacional, se contó con la participación de 22 soldados colombianos víctimas del conflicto armado interno y con algún grado de amputación, a quienes se les aplicó el Multidimensional body self relations questionnaire (MBSRQ), la Escala de estrés percibido (EEP-14) y el Connor-Davidson Resilience Scale (Cd-Risc 10). Los resultados muestran altas puntuaciones en conductas orientadas a mantener la forma física, atractivo físico autoevaluado y cuidado del aspecto físico, puntuaciones bajas en estrés y puntuaciones con tendencias altas en Resiliencia, así como una correlación negativa entre el estrés y las conductas orientadas a mantener la forma física.
Role of Methylglyoxal in Diabetic Cardiovascular and Kidney Diseases: Insights from Basic Science for Application into Clinical Practice
Authors: Sankaralingam Sowndramalingam , Ibrahim Angham , Rahman MD Mizanur , Eid Ali H. , Munusamy Shankar 
Published: September 2018

Background:
The incidence and prevalence of diabetes mellitus are increasing globally at alarming
rates. Cardiovascular and renal complications are the major cause of morbidity and mortality in patients with
diabetes. Methylglyoxal (MG) - a highly reactive dicarbonyl compound – is increased in patients with diabetes
and has been implicated to play a detrimental role in the etiology of cardiovascular and renal complications. Derived
from glucose, MG binds to arginine and lysine residues in proteins, and the resultant end products serve as
surrogate markers of MG generation in vivo. Under normal conditions, MG is detoxified by the enzyme glyoxalase
1 (Glo1), using reduced glutathione as a co-factor. Elevated levels of MG is known to cause endothelial and
vascular dysfunction, oxidative stress and atherosclerosis; all of which are risk factors for cardiovascular diseases.
Moreover, MG has also been shown to cause pathologic structural alterations and impair kidney function. Conversely,
MG scavengers (such as N-acetylcysteine, aminoguanidine or metformin) or Nrf2/Glo1 activators (such
as trans-resveratrol / hesperetin) are shown to be useful in preventing MG-induced cardiovascular and renal complications
in diabetes. However, clinical evidence supporting the MG lowering properties of these agents are
limited and hence, need further investigation.

Conclusion:
Reducing MG levels directly using scavengers or indirectly via activation of Nrf2/Glo1 may serve as
a novel and potent therapeutic strategy to counter the deleterious effects of MG in diabetic complications.
Design, Synthesis, SAR Study, Antimicrobial and Anticancer Evaluation of Novel 2-Mercaptobenzimidazole Azomethine Derivatives
Authors: Tahlan Sumit , Narasimhan Balasubramanian , Lim Siong Meng , Ramasamy Kalavathy , Mani Vasudevan , Shah Syed Adnan Ali 
Published: September 2018

Background:
Various analogues of benzimidazole are found to be biologically and therapeutically
potent against several ailments. Benzimidazole when attached with heterocyclic rings has
shown wide range of potential activities. So, from the above provided facts, we altered benzimidazole
derivatives so that more potent antagonists could be developed. In the search for a new category of antimicrobial
and anticancer agents, novel azomethine of 2-mercaptobenzimidazole derived from 3-(2-
(1H-benzo[d]imidazol-2-ylthio)acetamido)benzohydrazide were synthesized.

Results and Discussion:
The synthesized analogues were characterized by FT-IR, 1H/13C-NMR and
MS studies as well C, H, N analysis. All synthesized compounds were evaluated for in vitro antibacterial
activity against Gram-positive (B. subtilis), Gram-negative (E. coli, P. aeruginosa, K. pneumoniae and S.
typhi) strains and in vitro antifungal activity against C. albicans and A. niger strains by serial dilution
method, the minimum inhibitory concentration (MIC) described in μM/ml. The in vitro anticancer activity
of synthesized compounds was determined against human colorectal carcinoma cell line (HCT-
116) using 5-fluorouracil as standard drug.

Conclusion:
In general, most of the synthesized derivatives exhibited significant antimicrobial and anticancer
activities. Compounds 8, 10, 15, 16, 17, 20 and 22 showed significant antimicrobial activity
towards tested bacterial and fungal strains and compound 26 exhibited significant anticancer activity.
Marine Streptomyces sp. VITASP as a Source of New Bioactive Secondary Metabolites
Authors: Thosar Aditi , Satpathy Pooja , S. Jemimah Naine , Devi Chandrasekaran S. 
Published: September 2018

Background::
The main aim of the study was to evaluate the bioactive properties of ethyl
acetate crude extract of Streptomyces sp. VITASP with a view to assess their therapeutic potential.

Methods:
The morphological, physiological and the biochemical properties of the strain Streptomyces
sp. VITASP were confirmed by conventional methods. The present study evaluated the antibacterial,
antioxidant and cytotoxic activities.

Results:
The isolate was identified to be Streptomyces sp. (Genbank accession number: KR233807).
The ethyl acetate extract of Streptomyces sp. VITASP showed maximum antibacterial activity of two
Gram- positive and Gram- negative bacteria at 0.5mg/mL. The antioxidant potential of the crude extract
exhibited strong reducing power activity at 0.5 mg/mL with 93±0.05% inhibition. The antiinflammatory
and anti-diabetic properties were identified at 0.5 mg/mL concentration. The cytotoxic
effect was found with an IC50 of 500μg/ mL on HeLa cell lines. The GC-MS analysis and the chromatogram
patterns revealed major peak at 18.485 which corresponds to Pyrrolo[1,2-a]pyrazine-1,4-dione,
Hexahydro-3-(2-methylpropyl. IR spectra showed the functional groups. HPLC Retention time of the
peak was found to be 2.414 min.

Conclusion:
This work demonstrates that the extract should be considered as a useful source as an antioxidant
and antimicrobial agent and gives further insight into the potential use of the compounds as
drugs for various other bioactivities.
Role of Nrf2/HO-1 and PI3K/Akt Genes in the Hepatoprotective Effect of Cilostazol
Authors: Hassan Marwa , Ibrahim Mohamad A. , Hafez Heba M. , Mohamed Mervat Z. , Zenhom Nagwa M. , Abd Elghany Hend M. 
Published: September 2018

Background:Cilostazol, a phosphodiesterase 3 inhibitor (PDE3I), is a platelet aggregation inhibitor and vasodilator that is useful for treating intermittent claudication. Experimental studies have shown that cilostazol has potent anti-inflammatory, anti-oxidant effects effects.Objectives:Although the hepatoprotective effect cilostazol has been studied, the molecular mechanisms of such protection, including: the nuclear factor-erythroid 2-related factor 2 (Nrf2) / hemoxygenase (HO-1) and the phosphoinositide 3-kinase (PI3K) /serine/threonine kinase (Akt) pathways are not fully explored, which is the aim of this study.Methods:To achieve the aim of this study, 35 rats were grouped into: control groups, liver injury group (model- non treated: injected with thioacetamide (TAA), 150 mg/kg, i.p.), and two cilostazoltreated groups (treated with cilostazol 10 and 50 mg/kg, p.o.). The rats were treated for 8 days and injected with TAA on the 7th day of the experiment and sacrificed 48 hours after TAA injection.Results:The model group showed evidence of liver injury as indicated by the elevation of liver enzymes and confirmed by histopathological findings. TAA-induced liver injury was accompanied by down-regulation of the cytoprotective pathways: PI3K/Akt and Nrf2/HO-1 mRNAs. Cilostazol administration ameliorated TAA-induced liver injury, where it caused a significant improvement in the activity of liver enzymes as well as in the histopathological changes. Such an effect was associated with a significant increase in the expression of PI3K/Akt and Nrf2/HO-1 mRNAs as detected by Real-time reverse transcription polymerase chain reaction (RT-PCR).Conclusion:Cilostazol protected rats against TAA hepatotoxicity through up-regulation of PI3K/Akt and Nrf2/HO-1 gene expression.