bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral and Otorhinolaryngological Findings in Adults Who Were Diagnosed With Pediatric Onset Crohn’s Disease
Authors: Haaramo Anu , Alapulli Heikki , Aine Liisa , Tuokkola Jetta , Saarnisto Ulla , Roine Risto P. , Pitkäranta Anne , Kolho Kaija-Leena 
Published: June 2018

Background:
Up to 50% of pediatric patients with Crohn’s disease (CD) report oral manifestations, but less is known about their oral health when they become adults.

Goals:
Our aim was to provide detailed descriptions of the presence of oral and otorhinolaryngological manifestations in patients with pediatric onset CD once they reached adulthood, to look for predisposing factors and to compare the findings to matched controls.

Study:
Adult patients diagnosed with CD in childhood at the Children’s Hospital, University of Helsinki, Finland, after 2000 were invited for a follow-up appointment in 2016 and 24 were examined by a dentist and otorhinolaryngologist. They were compared with 22 matched controls from the Population Register Centre. The participants completed questionnaires about their general health, any special diets, and their health-related quality of life. Their nutrition was evaluated from food records.

Results:
Patients with CD had minor oral manifestations at a median of 9 years after their childhood diagnosis and the most common was angular cheilitis, which affected 6 patients and 1 control, but was not statistically significant (P=0.0984). CD with perianal abscessing disease correlated to orofacial findings (P=0.0312). Most of the patients had normal otorhinolaryngological findings. Subjects with oral lesions had lower mean health-related quality of life scores than subjects without oral findings and the differences were clinically but not statistically significant. Oral manifestations were not associated with differences in energy intake.

Conclusions:
Oral manifestations in adult patients with pediatric onset CD were mild and were not associated with otorhinolaryngological pathology.
Greater Reductions in Readmission Rates Achieved by Urban Hospitals Participating in the Medicare Shared Savings Program
Authors: Kim Yeunkyung , Thirukumaran Caroline P. , Li Yue 
Published: June 2018

Background:
Accountable Care Organizations in the Medicare Shared Savings Program (MSSP) have financial incentives to reduce the cost and improve the quality of care delivered to Medicare beneficiaries that they serve. However, previous research about the impact of the MSSP on readmissions is limited and mixed.

Objective:
To examine the association between hospital participation in the MSSP during the 2012–2013 period and reductions in 30-day risk-standardized readmission rates for Medicare patients initially admitted for acute myocardial infarction, heart failure (HF), pneumonia, or any cause.

Research Design:
Difference-in-differences estimation to compare the change in readmission rates for hospitals participating in the MSSP with that of other hospitals.

Subjects:
Acute care hospitals that either participated in the MSSP or did not participate in any of Medicare Accountable Care Organization programs (for acute myocardial infarction, n=1631; for HF, n=1889; for pneumonia, n=1896; for any cause, n=2067).

Results:
Compared with nonparticipating hospitals, MSSP-participating hospitals showed greater reductions in readmission rates for Medicare patients originally admitted for HF by 0.47 percentage points [95% confidence interval (CI), −0.76 to −0.17] and for pneumonia by 0.26 percentage points (95% CI, −0.49 to −0.03). MSSP-participating hospitals also showed more reductions in hospital-wide all-cause readmission by 0.10 percentage points (95% CI, −0.20 to 0.01), relative to nonparticipating hospitals during the first year of MSSP.

Conclusions:
MSSP-participating hospitals showed slightly greater reductions in readmissions during postimplementation years for Medicare patients initially admitted for HF or pneumonia, compared with other hospitals.
Multicenter Review of Current Practices Associated With Venous Thromboembolism Prophylaxis in Pediatric Patients After Trauma
Authors: Bigelow Amee M. , Flynn-O’Brien Katherine T. , Simpson Pippa M. , Dasgupta Mahua , Hanson Sheila J. 
Published: June 2018

Objectives:
Frequency of venous thromboembolism in pediatric trauma patients admitted to PICUs is not insignificant, ranging up to 6%. Risk factors have been identified in this population. However, there is little consensus of actual venous thromboembolism prophylaxis practice. We examined factors associated with venous thromboembolism prophylaxis in PICUs.

Design:
A retrospective study evaluating associations with mechanical venous thromboembolism prophylaxis, pharmacologic venous thromboembolism prophylaxis, or dual therapy (DUAL) prophylaxis compared with no venous thromboembolism prophylaxis. Multivariable logistic regression explored the relationship between prophylaxis type and selected covariates with stepwise selection method to identify the independent predictors of venous thromboembolism prophylaxis utilization.

Setting:
Five level I/II pediatric trauma centers in the United States.

Patients:
Children less than 18 years from January 1, 2013, to December 31, 2013, admitted to the PICU after a trauma, identified through combined trauma registry and Virtual Pediatric Systems database.

Interventions:
None.

Measurements and Main Results:
Six hundred ninety-two patients were included in the database, with 55 excluded for missing data. Of the remaining 637 patients, 538 (84.5%) had no venous thromboembolism prophylaxis by 48 hours, 77 (12.1%) had only mechanical venous thromboembolism prophylaxis, 11 (1.7%) had DUAL, and 11 (1.7%) had pharmacologic venous thromboembolism prophylaxis alone. Multivariable analysis showed increased age, and orthopedic procedure was associated with all forms of prophylaxis. Orthopedic procedures were associated with higher utilization of dual prophylaxis use (odds ratio, 5.2; 95% CI, 1.2–21.8), pharmacologic venous thromboembolism prophylaxis (odds ratio, 8.5; 95% CI, 2.3–31.7), and mechanical venous thromboembolism prophylaxis (odds ratio, 2.2; 95% CI, 1.1–4.2) alone. Brain/spinal cord procedures (odds ratio, 3.7; 95% CI, 1.9–7.3) and abdominal procedures (odds ratio, 6.6; 95% CI, 2.5–17.1) were associated with mechanical venous thromboembolism prophylaxis. Head injury was associated with a decreased use of any prophylaxis (odds ratio, 0.5; 95% CI, 0.3–0.9). Patient comorbidities were associated with decreased use of mechanical venous thromboembolism prophylaxis (odds ratio, 0.5; 95% CI, 0.3–1.0).

Conclusions:
Pharmacologic venous thromboembolism prophylaxis is not common in critically ill children after trauma. Patient age, orthopedic and vascular procedures, and higher injury severity are associated with pharmacologic venous thromboembolism prophylaxis.
The impact of news exposure on collective attention in the United States during the 2016 Zika epidemic
Authors: Tizzoni Michele , Panisson André , Paolotti Daniela , Cattuto Ciro 
Published: June 2018

AbstractIn recent years, many studies have drawn attention to the important role of collective awareness and human behaviour during epidemic outbreaks. A number of modelling efforts have investigated the interaction between the disease transmission dynamics and human behaviour change mediated by news coverage and by information spreading in the population. Yet, given the scarcity of data on public awareness during an epidemic, few studies have relied on empirical data. Here, we use fine-grained, geo-referenced data from three online sources – Wikipedia, the GDELT Project and the Internet Archive – to quantify population-scale information seeking about the 2016 Zika virus epidemic in the U.S., explicitly linking such behavioural signal to epidemiological data. Geolocalized Wikipedia pageview data reveal that visiting patterns of Zika-related pages in Wikipedia were highly synchronized across the United States and largely explained by exposure to national television broadcast. Contrary to the assumption of some theoretical models, news volume and Wikipedia visiting patterns were not significantly correlated with the magnitude or the extent of the epidemic. Attention to Zika, in terms of Zika-related Wikipedia pageviews, was high at the beginning of the outbreak, when public health agencies raised an international alert and triggered media coverage, but subsequently exhibited an activity profile that suggests nonlinear dependencies and memory effects in the relation between information seeking, media pressure, and disease dynamics. This calls for a new and more general modelling framework to describe the interaction between media exposure, public awareness and disease dynamics during epidemic outbreaks.
Crohn’s disease patients effectively mobilize peripheral blood stem cells to perform autologous haematopoietic stem cell transplantation
Authors: Ruiz Milton Artur , Kaiser Roberto Luiz , Piron – Ruiz Lilian , Peña-Arciniegas Tatiana , Castiglioni Lilian , Samara Saran Priscila , De Quadros Luiz Gustavo , Gouvea Faria Mikaell Alexandre , Siqueira Rubens Camargo , Liedtke Kaiser Fernanda Soubhia , Comenalli Marques José Francisco 
Published: June 2018

AbstractBackgroundTreatment with high doses chemotherapy followed by autologous haematopoietic stem cell transplantation is promising for refractory Crohn’s disease patients with no therapeutic option and at imminent risk of further surgeries.ObjectivesTo evaluate the feasibility and efficacy of haematopoietic progenitor cell mobilization in a group of Crohn’s disease patients preparing for autologous unselected haematopoietic stem cell transplantation in a single institution. This is the first study to evaluate mobilization for Crohn’s disease.MethodsPatients were selected according to criteria of the European Bone Marrow Transplant Society.ResultsAll patients mobilized with the mean number of haematopoietic progenitor cells obtained and infused being 16.17 × 106/CD34+/kg. Most patients required only one leukapheresis session to reach the ideal number of cells. Grafting occurred around ten days after cells infusion. Complications and adverse events during the mobilization period were rare with only one patient presenting sepsis as a relevant event in the period.Most patients 20 (70%) had anaemia from the beginning of the mobilization but only 11 (37.9%) received packed red blood cell transfusions.ConclusionMobilization in patients with Crohn’s disease is effective and it seems they are good mobilizers.
The Investment Concept of Sharia Insurance According to National Sharia Council and Its Regulation in Indonesia
Authors: LUTH Thohir , BURHANUDDIN BURHANUDDIN , SANTOSO Budi 
Published: June 2018

It is a fact that contemporary Islamic scholars have different opinion related to legalization of insurance (ta’mîn). The differences indicate there is a plurality in Islamic legal thought in responding contemporary issues which dynamic along with the change of time. This article is aimed to analysis the investmen concept of sharia insurance explained on dictum (fatwa) National Sharia Council (NSC) and its regulations which legitimize those enforcement. This discussion is important ‘to introduce the new concept of investing in the insurance products which later has caused controversy from the aspect of validity. The methods used to write this article is critical content analysis by making the NSC’s fatwa and the regulation of sharia insurance as its object, so both of which can be found the excellence and weakness of the concepts offered. The interesting of this concept is that the investment can be incorporated with insurance products, so that participants who pay a premium not only get guaranty indemnity of risk but also entitled to get a profit sharing of their fund investment. As for the weakness of this concept is the using of hybrid contract which tends to imposed to fullfil pragmatism needs, so that has opened new scientific debate from side of validity.
Land Plots as a Variety of Immovable Things
Authors: ZOLOTAREVA Alla Efratovna , STARODUMOVA Svetlana Jurievna , NEZNAMOVA Alla Andreevna , LENKOVSKAYA Renata Romanovna , VOLKOVA Maria Alexandrovna 
Published: June 2018

The article deals with attributes of immovable things, land plots in particular, as a special variety of an immovable thing. We have analyzed legal precedents, which allowed identifying various items of immovable property and relate them to each other. In our research, we used general scientific and law-specific methods of cognition: historical legal, formal legal, comparative legal, etc.
We have found gaps in the land legislation and civil legislation related to incomplete definitions and lack of clearly described attributes of immovable things. We have accounted for the latest legislative changes characterizing judicial attribute of any immovable property. Based on the identified attributes, we divided real estate into groups and provided a definition for the concept of a land plot as a special variety of real estate, without which things cannot exist and may not be divided into movable and immovable.
Deep-UV materials
Authors: Ehrt Doris 
Published: June 2018

Abstract
Materials with high deep-ultraviolet (DUV; λ<300 nm) transmission are important for many industrial applications. Fluoride single crystals and various glasses, pure SiO2, fluoride, phosphate, multicomponent silicates, and organic materials (PMMA), were investigated. The role of intrinsic absorption (UV edge) due to electron transitions between the main components, and extrinsic absorption due to trace impurities, effect of polyvalent ions, redox behavior, and radiation-induced transmission loss were considered. The optical basicity and optical properties were used to order the materials.
Thermally Induced Superlow Friction of DLC Films in Ambient Air
Authors: Zeng Qunfeng 
Published: June 2018

Abstract
Thermally induced superlow friction (0.008) of diamond-like carbon (DLC) films was achieved in ambient air in the present work. Raman and XPS (X-ray Photoelectron Spectroscopy) measurements and analyses show that superlow friction of the annealed DLC films is involved in the transformation of sp3 to sp2 hybridized carbon during annealing and the tribochemical reactions during sliding. The thermally activated graphitization and oxidation of the annealed DLC films in ambient air is beneficial to form the positively charged interface and achieve the stable superlow friction. A friction model was developed and applied to explain superlow friction, which is attributed to Van de Waals force between graphite layers and the repulsive force between hydroxyl group of graphite oxide and hydrogen terminated DLC films surface.
Crystal structure of (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl furan-2-carboxylate, C10H7FN2O5
Authors: Yan Xiaowei , Zhu Dongjian , Zhong Xing , Wang Sujuan 
Published: June 2018

Abstract
C10H7FN2O5, monoclinic, P21/n (no. 14), a = 8.5781(17) Å, b = 5.3121(11) Å, c = 23.578(5) Å, β = 96.68(3)°, V = 1067.1(4) Å3, Z = 4, R
gt(F) = 0.0375, wR
ref(F
2) = 0.1138, T = 293(2) K.
Effect of Caffeine on Sprint Cycling in Experienced Cyclists
Authors: Anderson Dawn E. , LeGrand Sarah E. , McCart Reece D. 
Published: June 2018

Abstract
Anderson, DE, LeGrand, SE, and McCart, RD. Effect of caffeine on sprint cycling in experienced cyclists. J Strength Cond Res 32(8): 2221–2226, 2018—Research regarding the ergogenic effects of caffeine (CAF) in anaerobic activity remains inconclusive. However, some researchers have found significant improvements in anaerobic performance when testing specifically trained athletes. A double-blind, placebo-controlled, counterbalanced, cross-over design was implemented to assess the impact of CAF on a 30-second Wingate Anaerobic Test (WAnT) in experienced cyclists. Nine experienced cyclists volunteered to participate in this study (men, n = 7 and women, n = 2). The subjects completed 2 separate experimental trials consisting of a 30-second WAnT at a resistance of 9% body mass. In a random order, 1 hour before each WAnT, subjects ingested either a CAF (∼280 mg) or placebo (PLAC) coffee. For each trial, heart rate (HR) and blood lactate (BL) values were recorded at rest, pre-WAnT, post-WAnT, and 5 minutes post-WAnT. After each trial, the subjects recorded their perception of which treatment they received. Heart rate and BL responses were not significantly different between the CAF and PLAC conditions. The ingestion of CAF did not significantly improve peak anaerobic power, mean anaerobic power, nor fatigue index. In at least 1 of the 2 trials, 44% of the subjects incorrectly guessed which substance they had ingested. The findings of this study do not show a significant correlation between CAF ingestion and improved anaerobic performance in experienced cyclists. However, performance enhancements may depend on varying individual responses to CAF. Athletes who are positive CAF responders may consider using coffee before competition to improve anaerobic performance.
Is female sex an independent risk factor for early mortality in isolated coronary artery bypass graft? A propensity-matched analysis
Authors: Garatti Andrea , Parolari Alessandro , Canziani Alberto , Mossuto Eugenio , Daprati Andrea , Abu Farah Ali , Brugnetti Daniele , Ranucci Marco , Menicanti Lorenzo 
Published: June 2018

Aims
Despite several studies reporting a higher mortality rate for women undergoing isolated coronary artery bypass graft (CABG) surgery, this issue has not been completely clarified. The aim of the current study was to determine if sex differences in CABG surgery affect adjusted operative results and operative mortality.

Methods
Between January 2005 and December 2012, 3756 consecutive patients (3009 men and 747 women) underwent isolated CABG at our institution. Women presented with older age, smaller BSA and higher rate of preoperative comorbidities. The propensity score methodology was used to obtain risk-adjusted outcome comparisons between the two groups.

Results
The distribution of preoperative variables among matched pairs (553 patients in both groups) was, on average, equal. Propensity-matched women received a similar number of distal anastomoses (P = 0.56), had similar rate of left internal thoracic artery (LITA) graft (P = 0.73) and comparable extracorporeal circulation (P = 0.61) and aortic cross-clamp (P = 0.39) time as men. Postoperative complications were comparable in the two study groups with the exception of postoperative transfusion rate which was significantly higher in women (P = 0.01). However, operative mortality (3.8 vs. 2.7%; P = 0.20), perioperative acute myocardial infarction (P = 0.50) and stroke (P = 0.75) were not significantly different between the two groups. Interestingly, after adjustment for the other baseline characteristics, female patients with diabetes (P = 0.03), preoperative renal dysfunction (P = 0.07) and obesity (P = 0.07) exhibited a greater operative mortality rate compared with men with the same comorbidities.

Conclusion
After adjustment for preoperative variables, female sex seems not to be an independent risk factor for early mortality in isolated CABG surgery. However, renal impairment, diabetes and obesity seem to play an important role in the operative risk profile of women undergoing isolated CABG.
A methodology for thermo-mechanical assessment of in-box LOCA events on fusion blankets and its application to EU DEMO HCPB breeding blanket
Authors: Zhou G. , Hernández F. A. , Zeile C. 
Published: June 2018

Abstract
Within the framework of EUROfusion research activities, the Karlsruhe Institute of Technology (KIT) is developing the Helium Cooled Pebble Bed (HCPB) breeding blanket (BB) for European demonstration fusion power plant (DEMO), with the support of BME and Wigner-RCP (Hungary) and CIEMAT (Spain). During the development of the BB concept in the past years, the in-box Loss Of Coolant Accident (LOCA) has been identified as a main design driver for BB. During this event, a leakage of pressurized coolant within the blanket box happens (in-box LOCA), pressurizing the blanket module and endangering its structural integrity. This accident has not been investigated in a detailed approach yet. In this paper, a more precise methodology is introduced taking into account the temperature evolution of the structure for assessing the structural integrity of BB under in-box LOCA and has been applied to the HCPB BB. The methodology and results are presented and critically discussed.
Analysis code development for the direct reactor auxiliary cooling system of the pool-type sodium-cooled fast reactor
Authors: Zhang D. L. , Song P. , Wang S. , Wang X. , Chen J. , Liang Y. , Qiu S. Z. 
Published: June 2018

Abstract
Sodium-cooled fast reactor (SFR) is one of the most promising reactors among the six Gen-IV reactor systems due to its significant advantages in close fuel cycle, comprehensive technology foundations and operation experiences. China is designing and constructing a demonstration SFR, in which, to ensure the reactor passive safety, a direct reactor auxiliary cooling system (DRACS) with the inter-wrapper flow is proposed as the decay heat removal system. Xi'an Jiaotong University is in charge of the DRACS analysis code development. The physical models in the DRACS are extracted and the numerical models for each component are established. The Gear method and the SIMPLE method are adopted as the primary solution algorithm. The code is developed and validated by EBR-II and PHENIX benchmarks, the results of which indicate that the code can predict experimental results very well.
The Inhibitory Action of Adsorbed Undiluted Plasma (normal or pathological) on the Thromboplastin Generation Test
Authors: Mayer G , Mayer S , Waitz R 
Published: June 2018

SummaryIn considering errors made during the search for a weak inhibitor of thromboplastin generation in a patient suffering from multiple myeloma, the authors recall the inhibitory action of adsorbed undiluted plasma added to a thromboplastin generation test. They stress the non-specificity of this inhibitory action which is common to all adsorbed plasma (normal, myelomatous or hemophilic) added undiluted to the test of Biggs and Douglas.
Urinary Outcomes in Patients with Down's Syndrome and Hirschsprung's Disease
Authors: Dingemans Alexander Johannes Martinus , Reck-Burneo Carlos Albert , Fuchs Molly , Sanchez Alejandra Vilanova , Lane Victoria Alison , Hoover Erin , Maloof Tassiana , Weaver Laura , Levitt Marc A. , Wood Richard J. 
Published: June 2018

Introduction Previous research in children with Hirschsprung's disease (HD) and Down's syndrome (DS) has focused on colorectal outcomes. We set out to review urinary outcomes in this patient group.
Materials and Methods The medical records of all patients aged five years and older with HD were reviewed, and patients and caregivers filled out the Vancouver Symptom Score at intake, which is designed and validated to diagnose dysfunctional elimination syndrome.
Results A total of 104 patients with HD were included in this study. Of these, 16 (15%) patients had DS. There were no significant differences in the prevalence of enterocolitis or colorectal symptoms between patients with or without DS. Five of 88 (6%) patients without DS and 7 of 16 (44%) (p = 0.00001) with DS reported having urinary accidents. Patients with HD and DS scored higher on the Vancouver score (9 vs. 17.5; p = 0.007), indicating more severe urinary symptoms. Patients who also reported fecal accidents scored significantly higher on the Vancouver (12 vs. 9; n = 61; p = 0.016), indicating more problems.
Conclusion Patients with DS appear to be a unique subset of HD patients who have a higher prevalence of urinary symptoms after surgery. In the postoperative care of patients with HD and DS, a strong focus should be placed on postoperative urinary care in addition to their bowel care. This could significantly ease care and contribute to the quality of life of the parents and the patient.