bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economics for the right to work
Authors: BRANCO Manuel C. 
Published: April 2019

AbstractThis article argues that mainstream economic theory is one of the main reasons why the human right to work, which was recognized by the international community in 1966, appears not to have been taken seriously. In the mainstream discourse, labour is a cost, employment is a second‐tier objective, individuals are resources with production specifications, and rights are rigidities. Economics based on human rights and seeking to promote the right to work must construe that right as more than just fighting unemployment, regard full employment as an end in itself and place the individual at the heart of its raison d'être.
Patterns of parents’ perspectives on protecting young children from secondhand smoke exposure: A Q‐methodology study
Authors: Huang Chiu‐Mieh , Liao Jung‐Yu , Huang Su‐Fei , Hsu Yi‐Ting , Hsu Hsiao‐Pei , Guo Jong‐Long 
Published: April 2019

AbstractAimsTo identify and describe the various patterns of parents’ perspectives on avoiding secondhand smoke exposure.DesignQ methodology was applied to investigate the parental perspectives of 50 parents.MethodsThe study was implemented from September–December 2016. Forty‐two Q‐statements were constructed based on the literature related to parental attitudes and prevention practices regarding preventing young children from experiencing secondhand smoke exposure. A series of Q‐sorts was performed by the participants to rank the statements into a Q‐sort grid. PQMethod 2.35 software was used to perform principal component analysis to identify different patterns of parents’ perspectives.ResultsFive patterns of shared perspectives, which accounted for 62% of the total variance, were derived from the analysis: (a) lack of confidence to confront smokers in non‐smoking areas; (b) awareness of health hazards but not ready to take preventive actions; (c) emphasis on parental responsibility and behavioural guidance; (d) awareness of health rights protected by legislation; and (e) strong willingness to take protective actions.ConclusionOur findings revealed the shared perspectives of five groups of parents. The exploration of clusters of parents could assist healthcare professionals in acknowledging parents’ tendencies related to attitudes and responses towards secondhand smoke exposure.ImpactUsing a forced distribution through the Q‐sorting technique, the particular perspective patterns of parents’ experiences would be captured. These findings can serve as a useful guide for researchers and practitioners to develop tailored intervention programs for parents with the purpose of reducing secondhand smoke exposure in young children.
Augmenter of liver regeneration protects the kidney from ischaemia‐reperfusion injury in ferroptosis
Authors: Huang Li‐li , Liao Xiao‐hui , Sun Hang , Jiang Xiao , Liu Qi , Zhang Ling 
Published: April 2019

AbstractAcute kidney injury (AKI) is a common and severe clinical condition with high morbidity and mortality. Ischaemia‐reperfusion (I/R) injury remains the major cause of AKI in the clinic. Ferroptosis is a recently discovered form of programmed cell death (PCD) that is characterized by iron‐dependent accumulation of reactive oxygen species (ROS). Compelling evidence has shown that renal tubular cell death involves ferroptosis, although the underlying mechanisms remain unclear. Augmenter of liver regeneration (ALR) is a widely distributed multifunctional protein that is expressed in many tissues. Our previous study demonstrated that ALR possesses an anti‐oxidant function. However, the modulatory mechanism of ALR remains unclear and warrants further investigation. Here, to elucidate the role of ALR in ferroptosis, ALR expression was inhibited using short hairpin RNA lentivirals (shRNA) in vitro model of I/R‐induced AKI. The results suggest that the level of ferroptosis is increased, particularly in the shRNA/ALR group, accompanied by increased ROS and mitochondrial damage. Furthermore, inhibition of system xc‐ with erastin aggravates ferroptosis, particularly silencing of the expression of ALR. Unexpectedly, we demonstrate a novel signalling pathway of ferroptosis. In summary, we show for the first time that silencing ALR aggravates ferroptosis in an in vitro model of I/R. Notably, we show that I/R induced kidney ferroptosis is mediated by ALR, which is linked to the glutathione‐glutathione peroxidase (GSH‐GPx) system.
miRNA‐210‐3p regulates trophoblast proliferation and invasiveness through fibroblast growth factor 1 in selective intrauterine growth restriction
Authors: Li Lin , Huang Xuan , He Zhiming , Xiong Yuanyan , Fang Qun 
Published: April 2019

AbstractSelective intrauterine growth restriction (sIUGR), which affects approximately 10%‐15% of monochorionic (MC) twin pregnancies, is highly associated with intrauterine foetal death and neurological impairment in both twins. Data suggest that unequal sharing of the single placenta is the main contributor to birth weight discordance. While MC twins and their placenta derive from a single zygote and harbour almost identical genetic material, the underlying mechanisms of phenotypic discrepancies in MC twins remain unclear. MicroRNAs are small non‐coding RNA molecules that regulate gene expression but do not change the DNA sequence. Our preliminary study showed that microRNA‐210‐3p (miR‐210‐3p) was significantly upregulated in the placental share of the smaller sIUGR twin. Here, we investigate the potential role of miR‐210‐3p in placental dysplasia, which generally results from dysfunction of trophoblast cells. Functional analysis revealed that miR‐210‐3p, induced by hypoxia‐inducible factor 1α (HIF1α) under hypoxic conditions, suppressed the proliferation and invasiveness of trophoblast cell lines. Further RNA sequencing analysis and luciferase reporter assays were performed, revealing that fibroblast growth factor 1 (FGF1) is an influential target gene of miR‐210‐3p. Moreover, correlations among miR‐210‐3p levels, HIF1α and FGF1 expression and the smaller placental share were validated in sIUGR specimens. These findings suggest that upregulation of miR‐210‐3p may contribute to impaired placentation of the smaller twin by decreasing FGF1 expression in sIUGR.
Fabella prevalence rate increases over 150 years, and rates of other sesamoid bones remain constant: a systematic review
Authors: Berthaume Michael A. , Di Federico Erica , Bull Anthony M. J. 
Published: April 2019

AbstractThe fabella is a sesamoid bone located behind the lateral femoral condyle. It is common in non‐human mammals, but the prevalence rates in humans vary from 3 to 87%. Here, we calculate the prevalence of the fabella in a Korean population and investigate possible temporal shifts in prevalence rate. A total of 52.83% of our individuals and 44.34% of our knees had fabellae detectable by computed tomography scanning. Men and women were equally likely to have a fabella, and bilateral cases (67.86%) were more common than unilateral ones (32.14%). Fabella presence was not correlated with height or age, although our sample did not include skeletally immature individuals. Our systematic review yielded 58 studies on fabella prevalence rate from 1875–2018 which met our inclusion criteria, one of which was an outlier. Intriguingly, a Bayesian mixed effects generalized linear model revealed a temporal shift in prevalence rates, with the median prevalence rate in 2000 (31.00%) being ~ 3.5 times higher than that in 1900 (7.64%). In all four countries with studies before and after 1960, higher rates were always found after 1960. Using data from two other systematic reviews, we found no increase in prevalence rates of 10 other sesamoid bones in the human body, indicating that the increase in fabella prevalence rate is unique. Fabella presence/absence is due to a combination of genetic and environmental factors: as the prevalence rates of other sesamoid bones have not changed in the last 100 years, we postulate the increase in fabella prevalence rate is due to an environmental factor. Namely, the global increase in human height and weight (due to improved nutrition) may have increased human tibial length and muscle mass. Increases in tibial length could lead to a larger moment arm acting on the knee and on the tendons crossing it. Coupled with the increased force from a larger gastrocnemius, this could produce the mechanical stimuli necessary to initiate fabella formation and/or ossification.
Factors that Influence Direction Deviation in Freehand Implant Placement
Authors: Tang Tianhong , Huang Zhuoli , Liao Luman , Gu Xiaoyu , Zhang Jiazheng , Zhang Xiuyin 
Published: April 2019

AbstractPurposeThis retrospective study investigates the accuracy of freehand implant placement and whether the factors of presence of an adjacent tooth, implant quadrant, number of missing teeth, and location of the implant site influence direction and angulation deviations.Materials and MethodsAccording to specific inclusion and exclusion criteria, a total of 112 implants from 75 partially edentulous patients were recruited for this retrospective study. The implants were inserted using a freehand approach by one experienced clinician (right‐handed). The full thickness flap was elevated to expose the alveolar bone in the implant surgery, and the implant crown consisted of an all‐ceramic restoration retained by cement. The planned implant position was preoperatively determined using implant planning software. The postoperative implant position was determined by analyzing the alignment after optically scanning the dentition using a specifically designed registration model in Geomagic Studio software. The deviations between the planned and postoperative implant positions were then calculated. The outcomes included direction and angulation deviations between the planned and postoperative implant positions. All data were analyzed by ANOVA, Bonferroni correction, regression analysis, and one‐sample t‐tests conducted using SPSS.ResultsThe 3D deviations between planned and postoperative implant positions were 1.22 ± 0.63 mm at the entrance point, 1.91 ± 1.17 mm at the apical point, and 7.93 ± 5.56° in angulation. The presence of adjacent teeth influenced deviations in the mesiodistal (F = 4.338, p = 0.006) and buccolingual directions (F = 3.017, p = 0.033) at the entrance point and mesiodistal angulation (F = 7.979, p < 0.001). The quadrant influenced deviation in the buccolingual direction at the apical point (F = 6.093, p = 0.001) and buccolingual angulation (F = 6.457, p < 0.001). The number of missing teeth had no effect on deviations of direction and angulation of implants. The location of the implant site affected the deviation in the buccolingual direction at the entrance point (F = 3.096, p = 0.049) and the mesiodistal direction at the apical point (F = 3.724, p = 0.027).ConclusionThe 3D accuracy of freehand‐placed implants could be acceptable in clinical situations. The results showed that the presence of an adjacent tooth and the quadrant and the location of the implant site influenced the direction and angulation deviations of the implant position; however, the factor of number of missing teeth did not.
Elevated C‐reactive protein in umbilical cord blood: Neonatal case review
Authors: Kitano Taito , Takagi Kumiko , Arai Ikuyo , Yasuhara Hajime , Ebisu Reiko , Ohgitani Ayako , Minowa Hideki 
Published: April 2019

AbstractBackgroundC‐reactive protein (CRP) has limited placental transportability. Relying on CRP level in umbilical cord blood alone is an inaccurate way to predict early onset neonatal sepsis, and we retrospectively reviewed the clinical courses of neonates with elevated CRP in umbilical cord blood.MethodsThis study was a retrospective case review of neonates with elevated CRP in umbilical cord blood (>0.5 mg/dL) in the Nara Prefecture General Medical Center, Nara, Japan between February 2013 and August 2017. We investigated the association of maternal and neonatal factors with neonatal clinical course. Then, we compared the cases of neonates with and without elevated CRP in umbilical cord blood.ResultsThe subjects consisted of a total of 22 neonates with elevated CRP in umbilical cord blood and 344 neonates without elevated CRP in umbilical cord blood. Of the 22 neonates with elevated CRP, 18 had some symptoms of sepsis at birth, but the symptoms of 85% of the symptomatic patients resolved ≤24 h after birth. Two neonates with elevated CRP in umbilical cord blood had bacteremia, and they had poor prognoses. Elevated CRP in umbilical cord blood was associated with length of antimicrobials (P = 0.021), immature/total neutrophil ratio (P = 0.017), and pathological chorioamnionitis (CAM; P = 0.028) on multivariable logistic regression analysis.ConclusionElevated CRP in umbilical cord blood was associated with pathological CAM. Most symptoms of sepsis resolved <24 h after birth.
Comparing Classification Trees to Discern Patterns of Terrorism*
Authors: Saiya Nilay , Scime Anthony 
Published: April 2019

ObjectiveThough applied widely in the fields of medicine, finance, ecology, psychology, and computer science, machine learning algorithmic‐based methods are a relatively novel approach to social scientific analysis that have yet to be extensively applied. Yet as we argue in this article, a specific form of algorithmic analysis known as C4.5 classification trees has much to offer social analysis and, specifically, the study of social and political violence.MethodThis article describes four novel classification model comparison techniques for the C4.5 classification method and applies them to the study of terrorism.ResultsOur state‐level analysis suggests that there is something fundamentally different in the targeting choices of religious and secular terrorists.ConclusionThis analysis highlights the ability of classification trees to heighten our understanding of terrorism and even provide recommendations to policymakers for avoiding future attacks.
Are Presidential Inversions Inevitable? Comparing Eight Counterfactual Rules for Electing the U.S. President*
Authors: Cervas Jonathan R. , Grofman Bernard 
Published: April 2019

ObjectivesWe offer a typology of possible reforms to the Electoral College (EC) in terms of changes to its two most important structural features: seat allocations that are not directly proportional to population and winner‐take‐all outcomes at the state level. This typology allows us to classify four major variants of “reform” to the present EC in a parsimonious fashion. Many of the proposals we consider have been suggested by well‐known figures, some debated in Congress, and they include what we view as most likely to be taken seriously. We evaluate these proposals solely in terms of one simple criterion: “Would they be expected to reduce the likelihood of inversions between EC and popular vote outcomes?”MethodsWe answer this question by looking at the data on actual presidential election outcomes at the state level over the entire period 1868–2016, and at the congressional‐district level over the period 1956–2016. We consider the implications for presidential outcomes of these different alternative mechanisms, in comparison to the actual electoral outcome and the popular vote outcome. In addition, we consider the implications of a proposal to increase the size of the U.S. House (Ladewig and Jasinski, 2008).ResultsOur results show that inversions from the popular vote happen under all proposed alternatives at nearly the same rate as under the current EC rules, with some proposals actually making inversions more frequent.ConclusionsThe major difference between the present EC rule and alternative rules is not in frequency of inversions, but is in which particular years the inversions occur. As for the proposal to increase the size of the House, we show that any realistic increase in House size would have made no difference for the 2016 outcome.
Cenozoic development of northern Svalbard based on thermochronological data
Authors: Dörr Nina , Lisker Frank , Piepjohn Karsten , Spiegel Cornelia 
Published: April 2019

AbstractNorthern Svalbard represents a basement high surrounded by the Norwegian‐Greenland Sea/Fram Strait, Eurasian Basin, the Barents Shelf and the onshore Central Tertiary Basin (CTB). Published apatite fission track (AFT) data indicate Mesozoic differential, fault‐controlled uplift and exhumation of the region. Thermal history modelling of published and new AFT and (U–Th–Sm)/He ages of 51–153 Ma in the context of regional stratigraphy and geomorphology implies at least two, possibly three, uplift and exhumation stages since late Mesozoic, separated by episodes of subsidence and sediment deposition. Late Cretaceous/Palaeocene exhumation and subsequent burial appear to be related with the transition of compressional to transpressional collision of Svalbard and Greenland during the Eurekan Orogeny. Renewed exhumation since the Oligocene probably results from passive margin formation after the separation of Svalbard and Greenland, when a new offshore sedimentary basin opened west of Svalbard. Final uplift since the Miocene eventually re‐exposed the palaeosurface of northern Svalbard.
Towards a molecular understanding of endosomal trafficking by Retromer and Retriever
Authors: Chen Kai‐En , Healy Michael D. , Collins Brett M. 
Published: April 2019

AbstractEndosomes are dynamic intracellular compartments that control the sorting of a constant stream of different transmembrane cargos either for ESCRT‐mediated degradation or for egress and recycling to compartments such as the Golgi and the plasma membrane. The recycling of cargos occurs within tubulovesicular membrane domains and is facilitated by peripheral membrane protein machineries that control both membrane remodelling and selection of specific transmembrane cargos. One of the primary sorting machineries is the Retromer complex, which controls the recycling of a large array of different cargo molecules in cooperation with various sorting nexin (SNX) adaptor proteins. Recently a Retromer‐like complex was also identified that controls plasma membrane recycling of cargos including integrins and lipoprotein receptors. Termed “Retriever,” this complex uses a different SNX family member SNX17 for cargo recognition, and cooperates with the COMMD/CCDC93/CCDC22 (CCC) complex to form a larger assembly called “Commander” to mediate endosomal trafficking. In this review we focus on recent advances that have begun to provide a molecular understanding of these two distantly related transport machineries.
A consensus redefinition of transfusion‐related acute lung injury
Authors: Vlaar Alexander P.J. , Toy Pearl , Fung Mark , Looney Mark R. , Juffermans Nicole P. , Bux Juergen , Bolton‐Maggs Paula , Peters Anna L. , Silliman Christopher C. , Kor Daryl J. , Kleinman Steve 
Published: April 2019

BACKGROUNDTransfusion‐related acute lung injury (TRALI) is a serious complication of blood transfusion and is among the leading causes of transfusion‐related morbidity and mortality in most developed countries. In the past decade, the pathophysiology of this potentially life‐threatening syndrome has been increasingly elucidated, large cohort studies have identified associated patient conditions and transfusion risk factors, and preventive strategies have been successfully implemented. These new insights provide a rationale for updating the 2004 consensus definition of TRALI.STUDY DESIGN AND METHODSAn international expert panel used the Delphi methodology to develop a redefinition of TRALI by modifying and updating the 2004 definition. Additionally, the panel reviewed issues related to TRALI nomenclature, patient conditions associated with acute respiratory distress syndrome (ARDS) and TRALI, TRALI pathophysiology, and standardization of reporting of TRALI cases.RESULTSIn the redefinition, the term “possible TRALI” has been dropped. The terminology of TRALI Type I (without an ARDS risk factor) and TRALI Type II (with an ARDS risk factor or with mild existing ARDS) is proposed. Cases with an ARDS risk factor that meet ARDS diagnostic criteria and where respiratory deterioration over the 12 hours before transfusion implicates the risk factor as causative should be classified as ARDS. TRALI remains a clinical diagnosis and does not require detection of cognate white blood cell antibodies.CONCLUSIONSClinicians should report all cases of posttransfusion pulmonary edema to the transfusion service so that further investigation can allow for classification of such cases as TRALI (Type I or Type II), ARDS, transfusion‐associated circulatory overload (TACO), or TRALI or TACO cannot distinguish or an alternate diagnosis.
Enhancement of excitatory transmission in NTS neurons projecting to ventral medulla of rats exposed to sustained hypoxia is blunted by minocycline
Authors: Lima‐Silveira Ludmila , Accorsi‐Mendonça Daniela , Bonagamba Leni G. H. , Almado Carlos Eduardo L. , da Silva Melina P. , Nedoboy Polina E. , Pilowsky Paul M. , Machado Benedito H. 
Published: April 2019

Key points
Rats subjected to sustained hypoxia (SH) present increases in arterial pressure (AP) and in glutamatergic transmission in the nucleus tractus solitarius (NTS) neurons sending projections to ventrolateral medulla (VLM).
Treatment with minocycline, a microglial inhibitor, attenuated the increase in AP in response to SH.
The increase in the amplitude of glutamatergic postsynaptic currents in the NTS‐VLM neurons, induced by postsynaptic mechanisms, was blunted by minocycline treatment.
The number of microglial cells was increased in the NTS of vehicle‐treated SH rats but not in the NTS of minocycline‐treated rats.
The data show that microglial recruitment/proliferation induced by SH is associated with the enhancement of excitatory neurotransmission in NTS‐VLM neurons, which may contribute to the observed increase in AP.
AbstractShort‐term sustained hypoxia (SH) produces significant autonomic and respiratory adjustments and triggers activation of microglia, the resident immune cells in the brain. SH also enhances glutamatergic neurotransmission in the NTS. Here we evaluated the role of microglial activation induced by SH on the cardiovascular changes and mainly on glutamatergic neurotransmission in NTS neurons sending projections to the ventrolateral medulla (NTS‐VLM), using a microglia inhibitor (minocycline). Direct measurement of arterial pressure (AP) in freely moving rats showed that SH (24 h, fraction of inspired oxygen () 0.1) in vehicle and minocycline (30 mg/kg i.p. for 3 days)‐treated groups produced a significant increase in AP in relation to control groups under normoxic conditions, but this increase was significantly lower in minocycline‐treated rats. Whole‐cell patch‐clamp recordings revealed that the active properties of the membrane were comparable among the groups. Nevertheless, the amplitudes of glutamatergic postsynaptic currents, evoked by tractus solitarius stimulation, were increased in NTS‐VLM neurons of SH rats. Changes in asynchronous glutamatergic currents indicated that the observed increase in amplitude was due to postsynaptic mechanisms. These changes were blunted in the SH group previously treated with minocycline. Using immunofluorescence, we found that the number of microglial cells was increased in the NTS of vehicle‐treated SH rats but not in the NTS neurons of minocycline‐treated rats. Our data support the concept that microglial activation induced by SH is associated with the enhancement of excitatory neurotransmission in NTS‐VLM neurons, which may contribute to the increase in AP observed in this experimental model.