bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of esophageal acidification on esophageal reflexes controlling the upper esophageal sphincter
Authors: Lang Ivan M. , Medda Bidyut K. , Shaker Reza 
Published: October 2018

Esophageal acid exposure can alter upper esophageal sphincter (UES) function, but the mechanism is unknown. The aim of this study was to determine the effects of esophageal acid exposure on esophago-UES relaxation (EURR) and contractile (EUCR) reflexes. Cats, decrebrate ( n = 27) or chronic ( n = 4), were implanted with electromyographic electrodes on pharynx, larynx, and esophagus. The esophagus was infused with either NaCl (0.9%) or HCl (0.1 N). The EUCR was activated by balloon distension in acute cats and slow air injection in chronic cats, and the EURR was activated by rapid air injection in both sets of cats. We found that NaCl infused for 15 or 30 min had no effect on EUCR or EURR in acute cats. HCl infused for 15, 30, or 45 min significantly ( P < 0.05) decreased the sensitivity to activate EUCR. HCl infused for 15 min significantly ( P < 0.05) increased and for 45 min significantly ( P < 0.05) decreased sensitivity to activate EURR. In chronic cats, HCl infused for 15 min/day increased sensitivity to activate EURR and decreased ( P < 0.05) sensitivity to activate EUCR after 4 days of infusion. EURR occurred spontaneously during HCl infusions on the 3rd and 4th ( P < 0.05) days of HCl infusion. We conclude that esophageal acid exposure initially sensitizes the esophagus to activation of EURR and desensitizes to activation of EUCR, but with longer exposure desensitizes to both. The alteration in sensitivity to activate EURR and EUCR caused by gastroesophageal reflux may play a role in the generation of supraesophageal reflux. NEW & NOTEWORTHY In acute studies, short-term esophageal acid exposure sensitizes esophagus to activation of esophago-upper esophageal sphincter relaxation response (EURR), whereas longer-term exposure inhibits EURR. Short- or long-term esophageal acid exposure decreases sensitivity to activation of esophago-upper esophageal sphincter contractile response (EUCR). In chronic studies, short-term esophageal acid exposure has the same effects on EURR and EUCR as occur acutely, but these effects take days to develop. Alteration in EURR and EUCR caused by gastroesophageal reflux may play a role in reflux disease.
CT-measured lung air-trapping is associated with higher carotid artery stiffness in individuals with chronic obstructive pulmonary disease
Authors: Luehrs Rachel E. , Newell John D. , Comellas Alejandro P. , Hoffman Eric A. , Warner Kelsey , Croghan Anna , DuBose Lyndsey E. , Nopoulos Peggy , Magnotta Vincent , Arndt Stephan , Pierce Gary L. , Hoth Karin F. 
Published: October 2018

Early stages of chronic obstructive pulmonary disease (COPD) are characterized by the loss and narrowing of terminal bronchioles in the lung, resulting in “air-trapping,” often occurring before overt emphysema manifests. Individuals with an airway-predominant phenotype of COPD display extensive lung air-trapping and are at greater cardiovascular disease (CVD) risk than COPD patients with an emphysema-predominant phenotype. We hypothesized that the degree of computed tomography (CT)-quantified lung air-trapping would be associated with greater aortic and carotid artery stiffness and lower endothelial function, known biomarkers of CVD risk. Lung air-trapping was associated with greater aortic stiffness (carotid femoral pulse wave velocity, CFPWV) ( r = 0.60, P = 0.007) and carotid β-stiffness ( r = 0.75, P = 0.0001) among adults with ( n = 10) and without ( n = 9) a clinical diagnosis of COPD and remained significant after adjusting for blood pressure (BP) and smoking history (pack-years) (carotid β-stiffness: r = 0.68, P < 0.01; CFPWV r = 0.53, P = 0.03). The association between lung air-trapping and carotid β-stiffness remained significant after additionally adjusting for age and forced expiratory volume 1(FEV1) ( r = 0.64, P = 0.01). In the COPD group only ( n = 10), lung air-trapping remained associated with carotid β-stiffness ( r = 0.82, P = 0.05) after adjustment for age, pack-years, and FEV1. In contrast, no association was observed between CFPWV and lung air-trapping after adjustment for BP, pack-years, age, and FEV1 ( r = 0.12, P = 0.83). Lung air-trapping was not associated with endothelial function (brachial artery flow-mediated dilation) in the entire cohort ( P = 0.80) or in patients with COPD only ( P = 0.71). These data suggest that carotid artery stiffness may be a mechanism explaining the link between airway-predominant phenotypes of COPD and high CVD risk. NEW & NOTEWORTHY Previous cross-sectional studies have demonstrated greater large elastic artery stiffness and lower endothelium-dependent dilation in chronic obstructive pulmonary disease (COPD) patients compared with controls. Furthermore, COPD patients with emphysema have greater aortic stiffness than non-COPD controls, and the degree of stiffness is associated with emphysema severity. The present study is the first to demonstrate that even before overt emphysema manifests, lung air-trapping is associated with carotid artery stiffness in COPD patients independent of blood pressure, age, or smoking history.
Effect of diaphragm fatigue on subsequent exercise tolerance in healthy men and women
Authors: Welch Joseph F. , Archiza Bruno , Guenette Jordan A. , West Christopher R. , Sheel A. William 
Published: October 2018

Women are more resistant to diaphragmatic fatigue (DF) and experience an attenuated inspiratory muscle metaboreflex relative to men. The effects of such sex-based differences on whole body exercise tolerance are yet to be examined. It was hypothesized that DF induced prior to exercise would cause less of a reduction in subsequent exercise time in women compared to men. Healthy men ( n = 9, age = 24 ± 3 yr) and women ( n = 9, age = 24 ± 3 yr) completed a maximal incremental cycle test on day 1. On day 2, subjects performed isocapnic inspiratory pressure-threshold loading (PTL) to task failure followed by a constant load submaximal time-to-exhaustion (TTE) exercise test at 85% of the predetermined peak work rate. On day 3, subjects performed the same exercise test without prior induced DF. Days 2 and 3 were randomized and counterbalanced. Magnetic stimulation of the phrenic nerve roots was used to nonvolitionally assess DF by measurement of transdiaphragmatic twitch pressure ( Pdi,tw). A similar degree of DF was produced in both sexes following PTL [ Pdi,tw (% change from baseline): M = −24.6 ± 7.8%, W = −23.1 ± 5.4%; P = 0.54)]. There was a significant reduction in TTE with prior induced DF compared with the control condition in both men (10.9 ± 3.5 min vs. 13.0 ± 3.2 min, P = 0.05) and women (10.1 ± 2.4 min vs. 12.2 ± 3.3 min, P = 0.03) that did not differ in magnitude between the sexes (M = −15.8 ± 19.5%, W = −14.5 ± 19.2%, P = 0.89). In conclusion, DF negatively and equally impairs exercise tolerance independent of sex. NEW & NOTEWORTHY Women are more resistant to diaphragmatic fatigue (DF) relative to men. The effect of DF on exercise tolerance is currently being debated. Our findings show that DF negatively and equally affects exercise tolerance in healthy men and women. Mechanisms beyond the inspiratory muscle metaboreflex (e.g., dyspnea, central fatigue, breathing pattern) may explain the absence of a sex-based difference.
On Touching the Violin
Authors: Hanly Peter 
Published: October 2018

Abstract
This essay considers the work of Jean-Luc Nancy on touch as a model for a conception of the musical body. More than a re-emphasizing of the tactile, though, it is possible to show that Nancy’s work enables an understanding of music as touch. The significance of this re-thinking lies in the counterweight it provides to the degradation of music entailed in its digitalized de-materialization. Hegel is seen to be complicit in this degradation.
Gadamer and the Hermeneutics of Early Music Performance
Authors: Thomas Mark J. 
Published: October 2018

Abstract
The success of the early music movement raises questions about performing historical works: Should musicians perform on period instruments and try to reconstruct the original style? If a historically “authentic” performance is impossible or undesirable, what should be the goal of the early music movement? I turn to Gadamer to answer these questions by constructing the outlines of a hermeneutics of early music performance. In the first half of the paper, I examine Gadamer’s critique of historical reconstruction and argue that this critique sheds light on mistaken tendencies and misunderstandings within the early music movement, but it does not discredit the movement as such. In the second half of the paper, I attempt to show how Gadamer’s dialogical account of historical consciousness provides a framework for understanding what historically informed performance is seeking to accomplish, as well as its advantage over a Nietzschean approach.
Postcolonial Capitalism and the Politics of Dispossession
Authors: Aung Geoffrey 
Published: October 2018

Abstract
This article examines the trajectory of struggles over land and resources in Dawei, a town in southern Myanmar. The site of a major special economic zone project, Dawei has seen sustained mobilisation around displacement, dispossession and environmental degradation, against the backdrop of national political and economic reforms. Recently, scholars have argued that earlier visions of postcolonial transition have lost their empirical and political purchase, as farmers dispossessed of land increasingly become excluded from formal capitalist production. What happens to politics and political form if dynamics of exclusion, rather than transition, organise political activity under today’s conditions of accumulation? Repurposing Kalyan Sanyal’s concept of postcolonial capitalism, this article describes and theorises the politics of dispossession in Dawei. Tracing the political activities of activist groups and villagers, it argues that two contrasting political trajectories—one secular–egalitarian, one situational–differential—constitute a heterogeneous political field, reflecting the complexity of postcolonial capitalism itself.
A new species of Aculus mite (Acari: Eriophyidae), a potential biocontrol agent for Australian swamp stonecrop, Crassula helmsii (Crassulaceae)
Authors: KNIHINICKI DANUTA K. , PETANOVIĆ RADMILA , CVRKOVIĆ TATJANA , VARIA SONAL 
Published: October 2018

A new, gall-forming eriophyoid mite species is described from Australia. Aculus crassulae sp. nov. was found causing significant leaf deformation in Crassula helmsii (Kirk) Cockayne (Crassulaceae), a semi-aquatic, succulent plant. Native to Australia and New Zealand, this plant is now a highly invasive weed in the United Kingdom and Western Europe. The host specificity of the new mite species, and damage caused to the host plant, infer its potential to be a valuable biological control agent in countries where Australian swamp stonecrop is threatening native flora. The species description provided here, which also includes a revised diagnosis for the genus Aculus, incorporates line drawings and scanning electron micrographs (SEM). This is supplemented by a partial mitochondrial gene sequence of cytochrome c oxidase subunit I (mtCOI) and the sequence was compared with Aculus amygdali Xue & Hong and Aculus ichnocarpi (Ghosh & Chakrabarati) available in the NCBI database. Pairwise comparison of mtCOI sequences between A. crassulae sp. nov. and two congeneric species revealed 22.6% and 23.1% genetic divergence, respectively.
Patterns, Impacts, and Future Projections of Summer Variability in the Arctic from CMIP5 Models
Authors: Cai Lei , Alexeev Vladimir A. , Walsh John E. , Bhatt Uma S. 
Published: October 2018

AbstractThirty models in phase 5 of the Coupled Model Intercomparison Project (CMIP5) are evaluated for their performances in reproducing two summertime atmospheric circulation patterns in the Arctic: the Arctic Oscillation (AO) and Arctic dipole (AD). The reference AO and AD are extracted from the ERA-Interim dataset (1979–2016). Model evaluation is conducted during the historical period (1901–2005). Models are ranked by a combined metrics approach based on two pattern correlation coefficients (PCCs) and two explained variances for the AO and AD, respectively. In the projected period (2006–2100), most models produce a positive trend for the AO index and a negative trend for the AD index in summer. The models ranked higher based on the combined metrics ranking show greater consistency and smaller values in the magnitudes of trends of AO and AD than the lower-ranked ones. The projected trends in the AO and AD contribute to a slight increase, if not a decrease, of the air temperature and an acceleration of precipitation increase in the twenty-first century over Arctic Alaska, which is the reverse of over the Barents and Kara Seas. Changes in the AO and AD are relatively minor contributing factors to the projected temperature and precipitation changes in the Arctic, among which the changes in the AD play a bigger role than those in the AO. The summer AO and AD have a stronger impact on the spatial asymmetry of the precipitation field than on the air temperature field.
Progress in Forecast Skill at Three Leading Global Operational NWP Centers during 2015–17 as Seen in Summary Assessment Metrics (SAMs)
Authors: Hoffman Ross N. , Kumar V. Krishna , Boukabara Sid-Ahmed , Ide Kayo , Yang Fanglin , Atlas Robert 
Published: October 2018

Abstract
The summary assessment metric (SAM) method is applied to an array of primary assessment metrics (PAMs) for the deterministic forecasts of three leading numerical weather prediction (NWP) centers for the years 2015–17. The PAMs include anomaly correlation, RMSE, and absolute mean error (i.e., the absolute value of bias) for different forecast times, vertical levels, geographic domains, and variables. SAMs indicate that in terms of forecast skill ECMWF is better than NCEP, which is better than but approximately the same as UKMO. The use of SAMs allows a number of interesting features of the evolution of forecast skill to be observed. All three centers improve over the 3-yr period. NCEP short-term forecast skill substantially increases during the period. Quantitatively, the effect of the 11 May 2016 NCEP upgrade to the four-dimensional ensemble variational data assimilation (4DEnVar) system is a 7.37% increase in the probability of improved skill relative to a randomly chosen forecast metric from 2015 to 2017. This is the largest SAM impact during the study period. However, the observed impacts are within the context of slowly improving forecast skill for operational global NWP as compared to earlier years. Clearly, the systems lagging ECMWF can improve, and there is evidence from SAMs in addition to the 4DEnVar example that improvements in forecast and data assimilation systems are still leading to forecast skill improvements.
A structured exercise programme combined with proprioceptive neuromuscular facilitation stretching or static stretching in posttraumatic stiffness of the elbow: a randomized controlled trial
Authors: Birinci Tansu , Razak Ozdincler Arzu , Altun Suleyman , Kural Cemal 
Published: October 2018

Objectives: To compare the different stretching techniques, proprioceptive neuromuscular facilitation (PNF) stretching and static stretching, in patients with elbow stiffness after a treated elbow fracture. Design: Randomized-controlled, single-blind study. Setting: Department of physiotherapy and rehabilitation. Subjects: Forty patients with posttraumatic elbow stiffness (24 women; mean age, 41.34 ± 7.57 years). Intervention: PNF stretching group ( n = 20), hold-relax PNF stretching combined with a structured exercise programme (two days per week for six weeks); static stretching group ( n = 20), static stretching combined with a structured exercise programme (two days per week for six weeks). Main measures: The primary outcome is the Disabilities of the Arm, Shoulder and Hand (DASH). The secondary outcomes are active range of motion (AROM), visual analogue scale (VAS), Tampa Scale for Kinesiophobia, Short Form-12 and Global Rating of Change. Participants were assessed at baseline, after a six-week intervention period and one-month later (follow-up). Results: After treatment, improvement in the mean DASH score was slightly better in the PNF stretching group (8.66 ± 6.15) compared with the static stretching group (19.25 ± 10.30) ( p = 0.03). The overall group-by-time interaction for the 2 × 3 mixed-model analysis of covariance (ANCOVA) was also significant for elbow flexion AROM (mean change for PNF stretching group; static stretching group; 41.10, 34.42, p = 0.04), VAS-rest (–1.31, –1.08, p = 0.03) and VAS-activity (–3.78, –3.47, p = 0.01) in favour of PNF stretching group. The other outcomes did not differ significantly between the two groups. Conclusion: The study demonstrated that the structured exercise programme combined with PNF stretching might be effective in patients with posttraumatic elbow stiffness with regard to improving function, elbow flexion AROM, pain at rest and during activity.
Epidemiological Evaluation of Meniscal Ramp Lesions in 3214 Anterior Cruciate Ligament–Injured Knees From the SANTI Study Group Database: A Risk Factor Analysis and Study of Secondary Meniscectomy Rates Following 769 Ramp Repairs
Authors: Sonnery-Cottet Bertrand , Praz Cesar , Rosenstiel Nikolaus , Blakeney William G. , Ouanezar Herve , Kandhari Vikram , Vieira Thais Dutra , Saithna Adnan 
Published: October 2018

Background: Ramp lesions are characterized by disruption of the peripheral meniscocapsular attachments of the posterior horn of the medial meniscus. Ramp repair performed at the time of anterior cruciate ligament reconstruction (ACLR) has been shown to improve knee biomechanics. Purpose: The primary objectives of this study were to evaluate the incidence of and risk factors for ramp lesions among a large series of patients undergoing ACLR. Secondary objectives were to determine the reoperation rate for failure of ramp repair, defined by subsequent reoperations for partial medial meniscectomy. Study Design: Case-control study; Level of evidence, 3. Case series; Level of evidence, 4. Methods: All patients underwent transnotch posteromedial compartment evaluation of the knee during ACLR. Ramp repair was performed if a lesion was detected. Potentially important risk factors were analyzed for their association with ramp lesions. A secondary analysis of all patients who underwent ramp repair and had a minimum follow-up of 2 years was undertaken to determine the secondary partial meniscectomy rate for failed ramp repair. Results: The overall incidence of ramp lesions in the study population was 23.9% (769 ramp lesions among 3214 patients). Multivariate analysis demonstrated that the presence of ramp lesions was significantly associated with the following risk factors: male sex, patients aged <30 years, revision ACLR, chronic injuries, preoperative side-to-side laxity >6 mm, and concomitant lateral meniscal tears. The secondary meniscectomy rate was 10.8% at a mean follow-up of 45.6 months (range, 24.2-66.2 months). Patients who underwent ACLR + anterolateral ligament reconstruction had a >2-fold reduction in the risk of reoperation for failure of ramp repair as compared with patients who underwent isolated ACLR (hazard ratio, 0.457; 95% CI, 0.226-0.864; P = .021). Conclusion: There is a high incidence of ramp lesions among patients undergoing ACLR. The identification of important risk factors for ramp lesions should help raise an appropriate index of suspicion and prompt posteromedial compartment evaluation. The overall secondary partial meniscectomy rate after ramp repair is 10.8%. Anterolateral ligament reconstruction appears to confer a protective effect on the ramp repair performed at the time of ACLR and results in a significant reduction in secondary meniscectomy rates.
Evaluating the Outcomes of Rotator Cuff Repairs With Polytetrafluoroethylene Patches for Massive and Irreparable Rotator Cuff Tears With a Minimum 2-Year Follow-up
Authors: Seker Vasanth , Hackett Lisa , Lam Patrick H. , Murrell George A.C. 
Published: October 2018

Background: Massive and irreparable rotator cuff tears are difficult to manage surgically. One technique is to use a synthetic polytetrafluoroethylene (PTFE) patch to bridge the tear. However, there is little information regarding the outcomes of this procedure. Purpose: To determine the ≥2-year outcomes of patients for whom synthetic patches were used as tendon substitutes to bridge irreparable rotator cuff defects. Study Design: Case series; Level of evidence, 4. Methods: This retrospective cohort study used prospectively collected data. Patients included those with a synthetic patch inserted as an interposition graft for large and/or irreparable rotator cuff tears with a minimum 2-year follow-up. Standardized assessment of shoulder pain, function, range of motion, and strength was performed preoperatively, at 6 and 12 weeks, and at 6 months and ≥2 years. Radiograph and ultrasound were performed preoperatively, at 6 months, and ≥2 years. Results: At a mean of 36 months, 58 of 68 eligible patients were followed up, and 53 of 58 (90%) patches remained in situ. Three patches failed at the patch-tendon interface, while 1 patient (2 shoulders/patches) went on to have reverse total shoulder replacements. Patient-ranked shoulder stiffness ( P < .001), frequency of pain with activity and sleep ( P < .0001), level of pain at rest and overhead ( P < .0001), and overall shoulder function improved from bad to very good ( P < .0001) by 6 months. Supraspinatus (mean ± SEM: 29 ± 16 N to 42 ± 13 N) and external rotation (39 ± 13 N to 59 ± 15 N) strength were the most notable increases at the ≥2-year follow-up ( P < .0001). Passive range of motion also improved by 49% to 67%; forward flexion, from 131° to 171°; abduction, from 117° to 161°; external rotation, from 38° to 55°; and internal rotation, from L3 to T10 ( P < .0001) preoperatively to ≥2 years. The most improvement in passive range of motion occurred between 12 months and ≥2 years. The mean (SD) Constant-Murley score was 90 (12), while the American Shoulder and Elbow Surgeons score was 95 (8). Conclusion: At 36 months postoperatively, patients who had synthetic patches used as tendon substitutes to bridge irreparable rotator cuff defects reported less pain and greater overall shoulder function as compared with preoperative assessments. They demonstrated improved range of passive motion and improved strength. The data support the hypothesis that the technique of using a synthetic PTFE patch to bridge a large and/or irreparable tear has good construct integrity and improves patient and clinical outcomes.