bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circadian rhythms of thyroid hormones in patients with ischemic heart disease, arterial hypertension, and atrial fibrillation
Authors: Tsareva Yu. O. , Mayskova E. A. , Fedotov E. A. , Shvarts Yu. G. 
Published: April 2019

Aim. To evaluate the interrelationship between diurnal changes in thyrotropic hormone (TTH), free triiodothyronine (FT3), and clinical features of IHD in combination with AH and atrial fibrillation (AF). Materials and methods. Levels of TTH, FT3, and plasma cortisol were measured in 133 patients with IHD and AH with or without paroxysmal AF. The studied indexes included duration of IHD, AH, and AF; presence or absence of AF and AH; incidence rate of AF episodes per week; severity of exertional angina; systolic and diastolic BP; and EchoCG data. Results. Morning and evening TTH levels were significantly different and reached high values in the morning and low values in the evening in most patients (n=91; 68.4%). A part of patients (n=42; 31.6%) showed an opposite tendency with high TTH values in the evening, i.e., inversion of the TTH fluctuations. Such patients more often had a history of myocardial infarction, a high class of exertional angina, and recurrence of paroxysmal AF. Patients with the TTH inversion had a shorter AH duration but somewhat higher BP. Conclusion. A part of IHD patients had inversed TTH circadian changes associated with more severe clinical manifestations of cardiovascular pathology.
Blood lipids and angina pectoris (by epidemiological cardiological Rose questionnaire) in the population of 25-45 years of Novosibirsk
Authors: Ragino Yu. I. , Shcherbakova L. V. , Denisova D. V. , Kuzminykh N. A. , Yachmeneva M. P. , Voevoda M. I. 
Published: April 2019

The aim of the study was to investigate the prevalence of angina pectoris (AP) according to the standardized epidemiological questionnaire of Rose in the population of 25–45 years of Novosibirsk and to identify its association with some lipid and non-lipid risk factors for coronary heart disease (CHD). Material and methods. Cross-sectional survey of the population aged 25–45 in Novosibirsk was carried out. The study included 1439 people (656 men and 783 women). Within the framework of the complex survey program, the standardized epidemiological questionnaire of Rose (WHO, 1984) was used. Blood levels of total cholesterol (total C), triglycerides (TG), low and high density lipoprotein cholesterol (LDL–C, HDL–C) were determinate by biochemical methods. Results. For all lipid indicators, significant differences were found between men and women. The levels of total C, TG and LDL–C were significantly higher, and the level of HDL–C was lower in men, than in women. According to the Rose questionnaire, out of 1439 people included in the study, 12 patients (0.8%) had AP (75% women). In persons with AP, blood levels of TG were 1.8 times higher, and the levels of HDL–C in blood was 1.2 times lower compared to persons without AP. Univariate analysis of associations of AP with CHD risk factors showed that the chance of developing angina pectoris in the population of 25–45 years was significantly increased in individuals with high blood TG levels (OR 3,515, DI 1,106–11,168, p = 0.039) and low HDL–C (OR 1,203, DI 1,054–1,372, p = 0.006). A natural, although statistically not significant (OR 3,165, p=0,055, due to the small number of groups with AP) increasing in the chance of developing AP in hypertension was detected. Conclusion. In the young population of 25–45 years in Novosibirsk, elevated blood levels of TG, reduced levels of HDL–C, and hypertension were associated with AP, according to Rosecardiological questionnaire, which underlines the importance of conducting screening surveys of the young population to improve effective prevention and treatment of diseases.
Pengembangan Panduan Mendesain Konten E-Learning pada Platform Totara
Authors: Pratiwi Maharani Eka , Nursetyo Kunto Imbar , Wirasti R.A Murti Kusuma 
Published: April 2019

The development research aims to produce a guidelines for designing e-learning content in general and spesific in Totara platform. The guides are packed in a printed book and leaflet. This guidelines is meant to be used by lecturer in FIP UNJ. This development research is referring to Rowntreeâ€™s model that consists of three major stages; planning; preparation of writing; writing and editing. The evaluation on this development research was conducted through expert review and face-to-face tryouts. The evaluation involving one subject matter expert, one media expert, and three users. The average value obtainded from the expert review by the subject matter expert was 3,6 overall excellent. The average value obtainded from the expert review by the media expert was 3,1 overall good. In face-to-face tryouts, obtained the average score 3,8 which signifies the overall guidance is excellent and can be used to guide lecturer in designing e-learning content, spesifically in Totara platform.
Peranan Knowledge Management dalam Meningkatkan Keunggulan Kompetitif BTPN Syariah
Authors: Muhammadsjah Anggiearanidipta Suma 
Published: April 2019

Knowledge has been recognized as the most difficult resource traded and imitated. The creation and use of knowledge needs to be managed at the level of individuals, groups, and companies. For the Bank itself, knowledge management is not organizing knowledge of their human resources as assets, but also as a key competitive advantage amid the global banking market. This paper discusses how knowledge management will be very beneficial for the BTPN Sharia to maintain a competitive advantage.
Pengetahuan sudah diakui sebagai sumber daya yang paling sulit diperdagangkan dan ditiru. Penciptaan dan penggunaan pengetahuan perlu dikelola dengan baik pada level individu, kelompok, maupun perusahaan. Bagi BTPN Syariah sendiri, manajemen pengetahuan bukan hanya sekedar mengatur pengetahuan sumber daya manusianya sebagai asset, tetapi juga sebagai kunci keunggulan kompetitif ditengah pasar global dunia perbankan. Paper ini membahas bagaimana manajemen pengetahuan akan sangat bermanfaat bagi BTPN Syariah untuk menjaga keunggulan kompetitif.
Identifying appropriate outcomes to help evaluate the impact of the Canadian Guideline for Safe and Effective Use of Opioids for Non-Cancer Pain
Authors: Allen Michael , Sproule Beth , MacDougall Peter , Furlan Andrea , Murphy Laura , Debono Victoria Borg , Buckley Norman 
Published: April 2019

Abstract
Background: The Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain (COG) was developed in response to increasing rates of opioid-related hospital visits and deaths in Canada, and uncertain benefits of opioids for chronic non-cancer pain (CNCP). Following publication, we developed a list of evaluable outcomes to assess the impact of this guideline on practice and patient outcomes.

Methods: A working group at the National Pain Centre at McMaster University used a modified Delphi process to construct a list of clinical and patient outcomes important in assessing the uptake and application of the COG. An advisory group then reviewed this list to determine the relevance and feasibility of each outcome, and identified potential data sources. This feedback was reviewed by the National Faculty for the Guideline, and a National Advisory Group that included the creators of the COG, resulting in the final list of 5 priority outcomes.

Results: Five outcomes were judged clinically important and feasible to measure: 1) Effects of opioids for CNCP on quality of life, 2) Assessment of patient’s risk of addiction before starting opioid therapy, 3) Monitoring patients on opioid therapy for aberrant drug-related behaviour, 4) Mortality rates associated with prescription opioid overdose and 5) Use of treatment agreements with patients before initiating opioid therapy for CNCP. Data sources for these outcomes included patient’s medical charts, e-Opioid Manager, prescription monitoring programs and administrative databases.

Conclusion: Measuring the impact of best practice guidelines is infrequently done. Future research should consider capturing the five outcomes identified in this study to evaluate the impact of the COG in promoting evidence-based use of opioids for CNCP.
How has urban water metabolism been communicated? Perspectives from the USA, Europe and Australia
Authors: King S. , Kenway S. K. , Renouf M. A. 
Published: April 2019

Abstract
Urban metabolism is increasingly being adopted to guide city planning towards improved water, energy and material efficiency. Stakeholder participation in the adoption of this concept will be important, and hence effective communication will be crucial. This study aimed to determine how urban metabolism has been communicated and interpreted, with attention to water. The approach included (i) literature review, (ii) structured international interviews and (iii) thematic analysis. We demonstrate how diverse language, metaphors, methods, visual imagery, data and information have been used to communicate this complex topic. Maps, Sankey diagrams, concept figures, spider diagrams, pictorial flow diagrams, art, and animation have all been used. We observe barriers to communication in order to understand the communication techniques which may be effective, and clarify issues relating to awareness and target audiences. We include a discussion of the themes that emerged from the research that are relevant for integrated water planning and the power of visual imagery. Inconsistent language is influenced by widely different overarching metaphors which range from ‘organism’ to ‘ecosystem’ metabolism. Fragmented data are a major gap for shared understanding. The research provides new understanding of how stakeholders perceive urban water metabolism and its relationship to Integrated urban water management.
Treatment with Radix Euphorbiae Ebracteolatae Significantly Decreases the Expression of E6 and L1, and Increases the Expression of p53 and Rb in HPV18-infected Human Foreskin Keratinocytes
Authors: He Xiang , He Xufeng , Xu Ping , Yang Lili , Ma Xin , Li Wen , Zhang Huimin 
Published: April 2019

Background:Radix Euphorbiae Ebracteolatae (REE) was recently reported to be significantly superior to vitamin A acid ointment in treating multiple plantar warts. However, the effects of REE on HPV18 remain unclear. Therefore, the current study aimed to investigate the effects of REE on the proliferation of HPV18, and explore possible molecular mechanisms underlying the effects.Methods:HFK and HFK-HPV18 were treated with water-extracted single or compound REE, ethanol-extracted single or compound REE, TNF-α and IFN for 3 days, respectively. In addition, the organotypic rafts containing HFK-HPV18 and HFK were treated with REE, IFN and TNF-α for 7 days, respectively. Cell proliferation rates were measured with Brdu. mRNA expression of E6, L1, p53 and Rb was detected by qPCR. Protein expression of p53, Rb and L1 was detected by Western blot.Results:Compared to HFK group, HFK-HPV18 group had significantly higher expression of E6 and L1. Compared to the control group, HFK-HPV18 treated with REE, TNF-α and IFN displayed significantly lower proliferation rates. The mRNA expression of E6 was markedly lower, and mRNA expression of p53 and Rb was significantly higher after treatment of REE in HFK-HPV18 or in organotypic rafts containing HFK-HPV18. Treatment with REE markedly increased the protein expression of p53 and Rb, and decreased the protein expression of L1 in HFK-HPV18 or in organotypic rafts containing HFK-HPV18. Among all formula of REE, the inhibition of proliferation rates and expression of E6 and L1, and the increase in expression of p53 and Rb in HFK-HPV18 was highest in ethanol-extracted compound REE group.Conclusions:The proliferation rates are significantly lower in HFK-HPV18 treated with REE. The expression of E6 and L1 is markedly lower, and expression of p53 and Rb is significantly higher after REE treatment in HFK-HPV18 or organotypic rafts containing HFK-HPV18. Among all formula of REE, ethanol-extracted compound REE displays the highest protection against HPV18.
Arterial Stiffness, Cognitive Dysfunction and Adherence to Antihypertensive Agents. Is there a Link to Hypertensive Patients?
Authors: Kalaitzidis Rigas G. , Panagiotopoulou Thalia , Stagikas Dimitrios , Pappas Kosmas , Balafa Olga , Elisaf Moses S. 
Published: April 2019

:The incidence of hypertension (HTN) and its cardiovascular (CV) complications are increasing throughout the world. Blood pressure (BP) control remains unsatisfactory worldwide. Medical inertia and poor adherence to treatment are among the factors that can partially explain, why BP control rate remains low. The introduction of a method for measuring the degree of adherence to a given medication is now a prerequisite. Complex treatment regimes, inadequate tolerance and frequent replacements of pharmaceutical formulations are the most common causes of poor adherence. In contrast, the use of stable combinations of antihypertensive drugs leads to improved patient adherence.:We aim to review the relationships between arterial stiffness, cognitive function and adherence to medication in patients with HTN.:Large artery stiffening can lead to HTN. In turn, arterial stiffness induced by HTN is associated with an increased CV and stroke risk. In addition, HTN can induce disorders of brain microcirculation resulting in cognitive dysfunction. Interestingly, memory cognitive dysfunction leads to a reduced adherence to drug treatment. Compliance with antihypertensive treatment improves BP control and arterial stiffness indices. Early treatment of arterial stiffness is strongly recommended for enhanced cognitive function and increased adherence.
Testing an Ectoin Containing Emollient for Atopic Dermatitis
Authors: Hon Kam Lun , Kung Jeng Sum , Ng Wing Gi Gigi , Leung Ting Fan 
Published: April 2019

Aim:
To describe the methodology in studying patient’s acceptability and efficacy of an
ectoin containing emollient for atopic dermatitis (AD).

Methods:
We described the methodology that we used in studying emollients and moisturisers, and
patient acceptability of a group of AD patients before and following usage of an ectoin-containing
proprietary emollient. These data were also compared with other brand emollients that we previously
reported, namely Restoradom®, Ezerra® and Ezerra plus®.

Results:
30 subjects (50% Male, Mean (SD) age: 9.8 (3.6) years with AD used the trial emollient
W for four weeks. AD severity of subjects (by objective SCORAD) was moderate (n=22) and severe
(n=8). Compliance was good and patients generally managed to use the moisturisers daily,
with individual reports of a ‘tingly’ sensation by some subjects when applied to inflamed wounds.
63% reported “very good” or “good”, whereas 37% reported “fair” or “poor” acceptability of the
moisturisers. Following use of the trial emollient, area affected, disease intensity and severity significantly
improved, as demonstrated in objective SCORAD (p=0.002). There were also significant
improvements in POEM (p=0.035), and PADQLQ scores (p=0.017). For skin measurements, only
transepidermal water loss had improved (p=0.035) after the treatment. There was no significant improvement
of itch or sleep scores, skin hydration, pH, S. aureus colonization status, or need for use
of topical medications. When compared with historical data of other emollients, the mean age of patients
on emollient W was younger; efficacy and acceptability among these emollients were similar.

Conclusions:
Methodology of emollient research is described. Doctors should provide evidencebased
information about the efficacy of emollients. The ectoin-containing proprietary emollient
improves disease and quality of life following its use in 4 weeks. Efficacy and acceptability are
similar among 4 proprietary emollients.
Primary Aldosteronism: Novel Insights
Authors: Stavropoulos Konstantinos , Imprialos Konstantinos , Papademetriou Vasilios , Faselis Charles , Tsioufis Kostas , Dimitriadis Kyriakos , Doumas Michael 
Published: April 2019

Background:
Primary aldosteronism is one of the most common causes of secondary
hypertension. Patients with this endocrine syndrome are at increased cardiovascular risk, higher
than hypertensive individuals with equal blood pressure levels.

Objectives:
The study aimed to thoroughly present and critically discuss the novel insights into the
field of primary aldosteronism, focusing on the clinically meaningful aspects.

Method:
We meticulously evaluated existing data in the field of primary aldosteronism in order to
summarize future perspectives in this narrative review.

Results:
Novel data suggests that a subclinical form of primary aldosteronism might exist. Interesting
findings might simplify the diagnostic procedure of the disease, especially for the localization of
primary aldosteronism. The most promising progress has been noted in the field of the molecular
basis of the disease, suggesting new potential therapeutic targets.

Conclusion:
Several significant aspects are at early stages of evaluation. Future research is essential
to investigate these well-promising perspectives.
Resampled Cox Proportional Hazards Models for Infant Mortality at the Kigali University Teaching Hospital
Authors: Gatabazi Paul , Melesse Sileshi Fanta , Ramroop Shaun 
Published: April 2019

Introduction:Resampling technique as a way of overcoming instability in Cox Proportional hazard model is used for measuring the risk and related standard error for the infant mortality, given socio-economic and clinical covariates for mother and children at the Kigali University Teaching Hospital in Rwanda.Methods:Bootstrap and jackknife Cox proportional hazards models was applied to N=2117 newborn data collected in 2016 at the Kigali University Teaching Hospital in Rwanda.Results:The unadjusted models revealed significance of the age of female parents, information on previous abortion, gender of a newborn, number of newborns at a time, APGAR, the weight of a newborn and the circumference of the head of a newborn.Conclusion:Statistical analysis supports two major findings: 1) parents under 20 years of age indicate a relatively higher risk of infant death, and 2) abnormality in the newborn's head and weight indicates a relatively higher risk of infant mortality. Recommendations include avoidance of pregnancy until after age 20 and clinically recommended nutrition for the mother during pregnancy to decrease the risk of infant mortality.
Genetic Polymorphisms of CYP2D6: Prevalence in Healthy Kurds
Authors: Ibrahim Muslih Abdulkarim , Zahari Zalina , Musa Nurfadhlina , Yin Khoo Boon 
Published: April 2019

Background:
Identifying the genetic polymorphisms of drug metabolizing enzyme
CYP2D6 is useful in pharmacogenomics. Unfortunately, until today, the prevalence
of the CYP2D6 polymorphisms among Kurds is scarce.

Objective:
In this study, we explored the CYP2D6 polymorphisms among Kurds.

Methods:
Four hundred and fifty-nine unrelated healthy Kurds were recruited for the
study. DNA was extracted from whole blood and was then used for genotyping
CYP2D6*3, *4, *5, *6, *9, *10, *17, *114 and gene duplication using the nested allelespecific
multiplex Polymerase Chain Reaction (PCR).

Conclusion:
The data add to our knowledge of CYP2D6 alleles, the genotypes and the
distributions of predicted phenotypes in Kurds. Majority of the observed variant alleles
confer no function and gene duplication. CYP2D6 polymorphisms were found to be very
heterogeneous in relation to genotype frequencies. Further study in relation to the evaluation
of drug therapy adjustment based on CYP2D6 genotype may help to understand the
clinical consequences of CYP2D6 polymorphisms.
In-vitro and in-vivo evaluation of antidiabetic activity of Withania coagulans extract
Authors: Patel Tejas , Suhagia B.N. 
Published: April 2019

Background:
Diabetes mellitus is major issue to public health as its prevalence is rising day by day. Synthetic agents available for the diabetic treatment are expensive or produce undesirable side effect on chronic use and some of them are not suitable during pregnancy. Herbal medicines accepted widely due to side effects and low cost.

Objective:
The aim of present study was to evaluate the activity of Withania coagulans extract using In-vitro and In-vivo model.

Methods:
Different three types of Withania coagulans extract were prepared using aqueous (W1), Alcohol (W2) and hydro-alcoholic (50:50) mixture (W3). In-vitro Anti-diabetic activity of the all three extracts evaluated using RINm5F Pancreatic beta cells.Further, n-vivo anti-diabetic evaluation performed by administering 50 mg/kg (p.o) aqueous extract for 7 days in Streptozotocin (STZ)-induced mice. Body weight of the animals was also determined to perform acute toxicity study.

Results:
The results of in –vitro cell based study indicated that among all three extract, aqueous extract (W1) of Withania coagulans showed potential increase in inulin release. The EC50 of the W1 (249.6 µg/L) which is compared with standard (Glibenclamide) EC50. From the results of In-vitro study, W1 subjected for acute toxicity study and the acute toxicity study results indicated LD50 of 50mg/kg. Diabetic rats treated with W1 extract at oral dose of 50 mg/kg for 7 days showed 34.17% reduction in blood glucose in comparison to untreated diabetic (STZ-induced) rats. Blood glucose levels of Standard treated (Glibenclamide) and control untreated.

Conclusion:
In conclusion, results of pancreatic beta cell based study showed increase in insulin release by administration of extract. Further aqueous extract (W1) was potentially reduced blood glucose level in STZ induced diabetic mice.
Cluster-based Ensemble Classification Approach for Anomaly Detection in the Internet of Things
Authors: Hosseini Mostafa , Brojeni Hamidreza Shayegh 
Published: April 2019

Background & Objective:
The next generation of the internet where physical things or
objects are going to interact with each other without human interventions is called the Internet of
Things (IoT). Its presence can improve the quality of human lives in different domains and environments
such as agriculture, smart homes, intelligent transportation systems, and smart grids.

:
In the lowest layer of the IoT architecture (i.e., the perception layer), there are a variety of sensors
which are responsible for gathering data from their environment to provide service for customers.
However, these collected data are not always accurate and may be infected with anomalies for
some reasons such as limited sensor’s resources and environmental influences.

:
Accordingly, anomaly detection can be used as a preprocessing phase to prevent sending inappropriate
data for the processing.

Methods:
Since distributed characteristic and its heterogeneous elements complicate the application
of anomaly detection techniques, in this paper, a cluster-based ensemble classification approach
has been presented.

Results & Conclusion:
Will possessing low complexity, the proposed method has high accuracy
in detecting anomalies. This method has been tested on the data collected from sensors in the Intel
Berkley research laboratory which is one of the free and available datasets in the domain of IoT.
The results indicated that the proposed technique could achieve an accuracy of 99.9186%, a positive
detection rate of 99.7459%, while reducing false positive rate and misclassification rate to
0.0025% and 0.0813% respectively.