bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between Employment Status, Loneliness, and Social Isolation: A Systematic Review
Authors: Sugiura Keiko , Takase Mai , Nakamoto Isuzu , Watanabe Saya , Murayama Hiroshi 
Published: November 2024

Abstract

Background
Loneliness and social isolation are significant concerns of public health globally. Although employment was one of the social participants, there is a dearth of literature examining the relationship between employment status and loneliness or social isolation. This study reviewed the relationship between employment status and loneliness/social isolation of adults.
Methods
For this systematic review, a computerized search was performed using PubMed, CINAHL, and PsycINFO for prospective studies published until May 2021. The observational studies were extracted according to study participants, indicators, follow-up period, statistical approach, and main results. The quality of the studies was assessed using the Newcastle-Ottawa Scale.
Results
Of the 3,214 records identified, nine studies were included in the systematic review based on the inclusion and exclusion criteria. Seven articles investigated loneliness, while the remaining two examined social isolation. Of the nine articles, two were from Israel, two from the US, and one each from Australia, Germany, Croatia, the Netherlands, and England. Approximately half the articles were published in the past decade. Only one of the nine articles used a longitudinal design. Four articles, whose samples covered all age groups, reported that being employed was associated with a lower sense of loneliness. The other three articles, whose samples consisted predominantly of people aged 30–64 years, reported a strong association between being employed and having a lower sense of loneliness. Only one of the seven studies reported an association between employment and loneliness among people aged 65 years or older. Two studies found no such association among that age group. The two studies that used social isolation as the outcome reported that employed people were significantly less isolated compared with unemployed people.
Conclusions
The review revealed that employed people are less likely to feel lonely or socially isolated. This study suggests that recommendations can be made for creating age-dependent employment conditions to avoid loneliness or social isolation.
The morbidity, viability and growth performance of water buffalo (Bubalus bubalis) calves during the growth phase can be affected by colostrum nutritional components as well as colostrum and calf’s serum non-nutritional components
Authors: Okuyucu ibrahim Cihangir , Erdem Hüseyin 
Published: November 2024

Abstract

This study aimed to investigate the effects of colostrum dry matter (DM), fat, solids-non-fat (SNF), protein, and lactose contents as well as colostrum and calf’s serum immunoglobulin (IgG, IgA, IgM), IGF-1, and lactoferrin concentrations on the morbidity, viability and growth performance of Anatolian buffalo calves during growth phase (0–6 mo). A total of 86 female and male calves, along with data from the dams of these calves, were utilized in the present study. Colostrum (at first milking) and calf serum samples (at 24–48 h and 28 d after birth) were analyzed with a milk analyzer and ELISA. Calves with high circulating concentrations of IgG at 24–48 h and IGF-1 and lactoferrin at 28 d during neonatal period (0–30 d and 31–60 d) had lower incidences of diarrhea than those with low concentrations. Calves with high circulating (at 24–48 h) concentrations of all Ig’s had higher viability at the 0–6 mo. Calves fed with colostrum with high DM, fat, SNF, protein, IgG, IGF-1 and lactoferrin content improved growth at different phases of the 0–6 mo, regardless of the volume of colostrum delivered. Consequently, variations in the concentration of some bioactive substances in colostrum and circulation can affect growth, disease and viability.
Ancestral Flavors of the Gastronomy of Catacaos in Peru: A Revaluation and Rescue
Authors: Aguirre-Sosa Joaquin , Dextre Maria Luisa , Vargas-Merino Jorge Alberto 
Published: November 2024

Abstract

Since the dawn of humanity, food has evolved beyond its basic function of sustenance, becoming an essential pillar of social life. Group hunting and farming not only ensured survival but also fostered cooperation and social cohesion. The aim of this research was to revalue the ancestral flavors of the gastronomy of Catacaos, Piura, Peru, by identifying and promoting traditional culinary practices through the “Flavors of the North” gastronomic festival. This qualitative study, with a descriptive-interpretive approach based on the ethnomethodological paradigm, included semi-structured interviews with key actors of the event. These interviews allowed for the exploration of the cultural, organizational, and social dynamics underlying the festival, integrating the perspectives of cooks, local entrepreneurs, and tourism managers. The study highlighted the richness of recipes and techniques passed down through generations, as well as the preservation of native ingredients and ancestral cooking methods. Gastronomic festivals are spaces to enjoy local cuisine and, as such, act as key tools for preserving cultural heritage, allowing new generations to connect with their roots. The revaluation of these ancestral flavors is crucial to safeguarding Catacaos' culinary memory in the face of cultural globalization, ensuring that its legacy remains alive and continuously evolves.
The Second Victim Experience and Support Tool: a cross-cultural adaptation, validation and psychometric evaluation of the Serbian version for pharmacy professionals (SR-SVEST-R)
Authors: Zimonjić Ivana , Marinković Valentina , Mira José Joaquín , Knežević Bojana , Djokic Borivoje-Boris , Bogavac-Stanojević Nataša , Odalović Marina 
Published: November 2024

Abstract

Background: The second victim phenomenon, involving emotional and psychological distress after adverse events, is underexplored among pharmacy professionals. The validated Second Victim Experience and Support Tool measures these experiences and support options, with the improved version also assessing resilience.
Aim: This study aimed to validate the Second Victim Experience and Support Tool-Revised, measure the second victim phenomenon, and present results among pharmacy professionals in Serbia.
Method: This cross-sectional study included 350 pharmacy professionals (MPharm and technicians). The questionnaire, with 9 factors and 35 statements, was translated and adapted following guidelines, and the content was validated by five experts. A pre-test with 30 participants ensured clarity, followed by Confirmatory Factor Analysis for construct validity and Cronbach's Alpha for reliability.
Results: Content validity was confirmed with item scores from 0.8 to 1 and an average scale score of 0.83. Factor analysis identified 9 factors and 30 items (Chi-square = 545.571, degrees of freedom = 366, p < 0.001). The model fit was supported by a Root Mean Square Error of Approximation of 0.037, a Comparative Fit Index of 0.958, a Tucker-Lewis Index of 0.950, and a Standardised Root Mean Square Residual of 0.040. Reliability analysis showed a Cronbach's alpha of 0.88, with factor values from 0.60 to 0.90. Among participants, 49.5% feared future events, 47.4% felt exhausted, 22.6% considered quitting, 72.6% valued peer support, and 28.9% improved work quality.
Conclusion: The Serbian resilience measuring version effectively evaluates the second victim experience and support options among pharmacy professionals, showing good validity and reliability.
A Noval RUL Prediction Method for Rolling Bearing: TcLstmNet-CBAM
Authors: Liu Qiang , Dai Zhengwei , Lai Hongxi , Chen Minghao , Huang Huiyuan , Fu Jiahui , Hou Mingxin , Xu Xiaoming , Wang Guangbin , Yan Jin 
Published: November 2024

Abstract

Rolling bearings are pivotal components within rotating mechanical systems, and accurately predicting their remaining service life holds significant practical importance. This paper addresses issues prevalent in common deep learning methods for predicting remaining useful life (RUL), notably inadequate feature extraction and low prediction accuracy resulting from reliance solely on short-term or long-term dependent features.In this paper, we introduce a residual useful life prediction method for bearings, named TcLstmNet-CBAM. This method integrates CBAM attention alongside parallel Temporal Convolutional Network (TCN) and Long Short-Term Memory (LSTM). Specifically, it employs a parallel network architecture for feature extraction, TCN extracts long-term temporal relationships and quickly mines deep spatial features to capture short-term time series relationships using LSTM. Additionally, the method incorporates the CBAM attention mechanism to assign weights to features across various dimensions, emphasizing the significance of important features.This approach not only achieves a more comprehensive feature distribution but also enhances the representation of crucial features, consequently leading to improved accuracy in predicting RUL. Finally, to validate the effectiveness of the proposed approach, we conducted experiments on the PHM2012 and XJTU-SY rolling bearing datasets, comparing its performance against several other prevalent deep learning prediction methods. The results demonstrate the robustness and generalization capability of the proposed method.
Risk factors of histological crescent formation in children IgA vasculitis with nephritis
Authors: Yang He , Lin Qian , He Xue , Fu Haidong , Jin Yanyan 
Published: November 2024

Abstract

Objective:This study aimed to explore the risk factors of histological crescent formation in children IgA vasculitis with nephritis (IgAV-N).
Methods:Enrolled patients with biopsy-proven IgAV-N from Zhejiang University’s hospital were split into two groups: 377 with no crescents (group 1) and 364 with crescents (group 2). Collected data included clinical features, lab indicators, pathological grading, and renal fibrosis indicators. Logistic regression was used to assess factors affecting crescent formation in IgAV-N. Double immunofluorescence assay detected TGF-β1, MCP-1, α-SMA, Collagen I, and FN1 in specimens. The relationship between renal fibrosis factors and pathological grade was analyzed using chi square and Pearson tests.
Results:A total of 741 patients with IgAV-N were included in the study. Univariate logistic regression identified potential factors related to crescent formation, including age, gender, clinical classification, hematuria grade, 24-hour urine protein grade, blood WBC, ALB, Cys-C, APTT, and PT. Multivariate analysis revealed statistical significance for age, 24-hour urine protein, and blood WBC across pathological levels (P<0.05). Mantel-Haenszel chi-square test indicated a linear relationship between IgAV-N pathological grade and α-SMA, TGF-β1, MCP-1, and FN1. Pearson correlation analysis confirmed a positive correlation between pathological grade and these markers.
Conclusions: Age, 24-hour urinary protein, and blood WBC are identified as risk factors for histological crescent formation in children with IgAV-N. Additionally, a higher pathological level is associated with more pronounced fibrosis indicators.
Nexus of corporate governance, political stability and Performance: Evidence from IPOs of an emerging economy
Authors: Waris Muhammad 
Published: November 2024

Abstract

Purpose
The purpose of this study is to investigate the nexus of corporate governance, political stability and Performance in IPOs of an emerging economy such as Pakistan.
Material and Methods
The data used in this study were obtained from the annual reports of IPO-listed firms in Pakistan between 2008 to 2022. We used different methods such as regression analysis, random effect model, and GMM methods in the analysis process.
Findings and Conclusion
: Our results show that an independent board has a significant positive relationship with performance. Moreover, board size has both a negative and positive relationship with the performance of the IPOs. Gender diversity has a significant positive relationship with IPO performance. Moreover, the age of the firm has a significant positive relationship with IPO performance. Political stability within the country has a positive relationship with IPO performance, whereas the political instability decreases the performance and vice versa.
Policy Implications:
This study provides practical implications to the government and investors; the government makes a code of corporate governance to increase the number of corporations by improving their Initial return and Investors use the study to evaluate the corporation with an effective code of corporate governance for protecting their investment.
Bibliometric analysis of tumor-associated macrophages and colorectal cancer
Authors: Gao Yadi , Yuan Weichen , Zhang Jiexiang , Wang Zhiwei , Cui Wenwen , Guan Zhongan 
Published: November 2024

Abstract

Background
Colorectal cancer (CRC) progression is closely related to the tumor microenvironment (TME). Tumor-associated macrophages (TAMs), the predominant immune cells in the TME, facilitate proliferation, invasion, metastasis, angiogenesis, chemoresistance, and immunosuppression in CRC.TAMs play significant roles in both the pathological processes and therapeutic strategies of CRC. The mutual pathological mechanisms remain unclear, necessitating an in-depth study of the relationship between TAMs and CRC. This paper employs bibliometric methods to analyze TAMs and CRC research literature, aiming to assess current trends, evaluate the research status, and forecast future directions and emerging topics.
Methods
Publications from the Web of Science Core Collection (WOSCC) database were searched between January 1, 2001, and July 31, 2024. Following the establishment of specific search criteria for time, publication type, and language, bibliometric analysis and data visualization were conducted using Microsoft Excel, R software, VOSviewer, and CiteSpace.
Results
This study included 1218 publications, written by 8,302 authors from 61 countries and 1,657 institutions, published in 427 journals, covering 4,451 keywords and citing 65,174 references. During the period 2017–2023, the number of publications increased rapidly. The most published and most cited country is China. The leading research institutions were Sun Yat Sen University, Zhejiang University, and the Chinese Academy of Sciences, all located in China. Mantovani, Alberto, was the most prolific and cited author from Humanitas University. The primary research disciplines included molecular, biology, immunology, medicine, and genetics. Keyword co-occurrence and literature co-citation analysis identified NF-κB (nuclear factor kappa-B), endothelial growth factor, angiogenesis, polarization, TME, immune response, PD-1 blockade, immune checkpoint inhibitors, and metabolism as current research hotspots and trends in this field.
Conclusion
This study employed bibliometric methods to comprehensively analyze and visualize research papers in TAMs and CRC published from 2001 to July 31, 2024. The objective was to assess the current research status, hotspots, and development trends in targeting TAMs for CRC, aiming to provide a reference point and information to establish TAMs as a novel driving force for CRC treatment.
Effect of the phase transition on the dynamics of COVID19 drugs trapped inside lipid bilayers
Authors: Singh Satnam 
Published: November 2024

Abstract

Investigating the dynamics of drugs inside lipid bilayers to understand their effects on drug efficacy and cellular functions. In this work, the dynamics of three COVID-19 drugs inside two lipid bilayers are studied using molecular dynamics simulations. The three drugs, Baricitinib (C16H17N7O2S), Nirmatrelvir (C23H32F3N5O4), and Remdesivir (C27H35N6O8P), and the two lipid bilayers, Dimyristoylphosphatidylcholine (C36H72NO8P) and Dipalmitoylphosphatidylcholine (C40H80NO8P), are selected to encapsulate the drugs. We study the diffusion of the drugs, radial distribution function, hydrogen bonding between drugs and lipids, and dihedral angles of the drugs. Additionally, the oral bioavailability of the three drugs is studied. Moreover, lipid parameters such as the area per lipid and deuterium order parameters are also examined. We found that changes in the phase of the bilayer significantly impact the dynamics of the drugs. The hydrogen bonding between the lipid and drug increases as the phase of the lipid changes from solid to liquid. Changes in the area per lipid and deuterium order parameters are also clearly observed.
CT and MRI characteristics of ovarian mucinous tumors arising from mature cystic teratomas
Authors: Hattori Mayu , Kato Hiroki , Kawaguchi Masaya , Kobayashi Kazuhiro , Nishibori Hironori , Furui Tatsuro , Isobe Masanori , Noda Yoshifumi , Hyodo Fuminori , Matsuo Masayuki 
Published: November 2024

Abstract

Purpose: This study aimed to evaluate the CT and MRI features of ovarian mucinous tumors arising from mature cystic teratomas.
Materials and methods: A total of 34 patients (age range, 12–74 years; mean age, 39 years) with histopathologically proven ovarian mucinous tumors arising from mature cystic teratomas were enrolled in the present study. All patients underwent preoperative pelvic CT and/or MRI. Imaging findings were retrospectively reviewed.
Results: Histopathological diagnosis of mucinous tumors included mucinous cystadenoma in 22 patients, mucinous borderline tumor (MBT) in 10 patients, and mucinous carcinoma in two patients. The mean maximum tumor diameter was 167 mm (range, 39–314 mm). All tumors were unilateral, well-defined, predominantly cystic, and multilocular. A total of 14 tumors (41%) had fewer than 10 loculi, while 12 tumors (35%) had 30 or more. Fatty components were observed in 30 tumors (88%), and 20 of 30 tumors (67%) had multiple fatty components. On MRI, stained glass appearance was observed in 20 of 29 tumors (69%). On CT, nodular calcifications within fatty components were observed in 12 of 21 tumors (57%), whereas flattened calcifications within the septa of non-fatty components were observed in 7 of 21 tumors (33%). Pseudomyxoma peritonei (PMP) was observed in three patients (9%) with MBT.
Conclusion: Ovarian mucinous tumors arising from mature cystic teratomas typically presented as large, multilocular cystic lesions with fatty components and teratoma/mucinous tumor-associated calcifications. Although PMP was uncommon, it was rarely observed in patients with MBT.
Correlation of Quantitative HBsAg with HBV DNA levels in treatment naïve Chronic Hepatitis B patients.
Authors: Malik Praveen Kumar , Varun Varun Shahi , Heli Heli Kapoor , Nikhil Nikhil Verma , Raman Raman Parashar , Taneja Rajesh Satyapal Taneja R S 
Published: November 2024

Abstract

Background This was a cross-sectional analytical study evaluating treatment naive CHB patients visiting department of Medicine at our tertiary care centre between January 2023 - March 2024. Demographic details and laboratory parameters like HBV DNA, Quantitative HBsAg (qHBsAg), HBeAg status, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, albumin was noted. The purpose of the study was understanding the correlation between qHBsAg and HBV DNA levels is critical for optimizing clinical decision-making in chronic hepatitis B management. If a strong correlation is established, qHBsAg could potentially serve as an alternative or adjunctive marker for monitoring disease progression, assessing treatment response, and predicting outcomes. Moreover, if qHBsAg proves reliable as a surrogate for HBV DNA levels, it could streamline patient care by reducing the need for frequent HBV DNA testing, particularly in resource-limited settings where sophisticated molecular assays may be scarce.Results 50 treatment-naïve chronic hepatitis B patients were enrolled to evaluate the correlation between quantitative HBsAg and HBV DNA levels. The cohort had a mean age of 44.56 years, predominantly male (68%). Serological tests showed all patients were positive for Total Anti HBc, with 34% HBeAg-positive and 66% HBeAg-negative. Mean HBV DNA levels were 100,217,224.45 IU/mL, and quantitative HBsAg levels averaged 3117.78 IU/mL. The correlation between quantitative HBsAg and HBV DNA was very weak and non-significant, with coefficients of 0.049 in overall study patients, 0.194 in HBeAg-reactive patients, and 0.192 in non-reactive patients.Conclusion The study found a predominantly non-significant correlation between quantitative HBsAg and HBV DNA levels, suggesting HBsAg alone may not reliably predict HBV DNA or disease activity in chronic HBV patients.
Quantitative EEG characteristics and prediction of neuromotor development in premature neonates with brain injury
Authors: Shan Yuanyuan , Zhang Lin , Zhang Peng , Xu Yan , Wang Jun , Yang Mingshu , Cheng Guoqiang 
Published: November 2024

Abstract

Objective
The objective of this study was to identify relevant quantitative parameters to distinguish premature infants with presence of brain injury from conventional EEGs and predict short-term neuromotor developmental outcomes.
Methods
This is a prospective cohort study of newborns at 34 weeks’ gestation or earlier. Multichannel EEG recordings were performed within the first 3 days after birth. The total power (TP), absolute and relative band power (ABP and RBP), alpha/theta ratio (ATR), alpha/ delta + theta ratio (ADTR), 95% spetral edge frequency (SEF), approximate entropy (ApEn), coherence and brain symmetry index (BSI) were calculated using the Auto-Neo-EEG signal processing system. Neonates were divided into two groups: with and without brain injury, and clinical outcomes of general movements (GMs) assessment at three months were available for analysis.
Results
Preterm infants with brain injury had significantly lower TP, ABP-δ, ABP-α, RBP-δ and coherence than those without brain injury (P values were 0.008, 0.002, 0.019, 0.035, 0.025, respectively). The area under curve (AUC) of TP, ABP-δ, ABP-α, RBP-δ and coherence for predicting brain injury was 0.749, 0.830, 0.721, 0.799 and 0.743, respectively. When TP, ABP-δ, ABP-α, RBP-δ and coherence were taken as cut-off values (53.46µV2, 78.55µV2, 6.28µV2, 35.58%, 0.13), the sensitivity reached 84.1%, 81.5%, 70.6%, 79.1%, 49.2%, and the specificity were 58.7%, 83.1%, 60.5%, 67.8%, 90.1%, respectively, to distinguish brain injury. Preterm infants with brain injury had significantly lower GMs optimimality scores (15.6 ± 6.7) than those without brain injury (28.4 ± 8.3) (P = 0.019). For 43 preterm infants with brain injury, TP (P = 0.023) and ABP-δ (P = 0.030) were positively correlated with GMs optimimality scores; while coherence (P = 0.039) was the opposite.
Conclusions
Compared with those without brain injury, preterm infants with brain injury tended to have reduced spectral power, accompanied by impaired brain network connectivity, and delayed motor development. Automated qEEG analysis provides predictive value on the occurrence of brain injury and outcomes in preterm neonates, among which ABP-δ presenting the best predictive value.