bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluoreszenzoptische Bildgebung zum Nachweis einer möglichen Psoriasisarthritis im Vergleich zum muskuloskelettalen Ultraschall
Authors: Erdmann‐Keding Magdalena , Ohrndorf Sarah , Werner Stephanie Gabriele , Glimm Anne‐Marie , Burmester Gerd‐Rüdiger , Kokolakis Georgios , Zuberbier Torsten , Sterry Wolfram , Backhaus Marina , Philipp Sandra 
Published: September 2019

ZusammenfassungZielVergleich der fluoreszenzoptischen Bildgebung (fluorescence optical imaging, FOI) mit Graustufen‐ (GS) und Power‐Doppler‐Ultraschall (PDUS) zum Nachweis von Gelenkentzündung bei Patienten mit bestätigter Psoriasisarthritis (PsA) oder mit Verdacht auf PsA.MethodenPatienten (n = 60) mit Psoriasis und druckschmerzhaften und/oder geschwollenen Gelenken wurden in zwei Gruppen eingeteilt: Diagnose vor dem Start der Studie vom behandelnden Dermatologen bestätigt (n = 26) und Verdacht auf PsA (n = 34). GS/PDUS der klinisch stärker betroffenen Hand wurde in dorsaler/palmarer Ansicht durchgeführt (Handgelenk, MCP, PIP, DIP2–5). Die FOI‐Untersuchung erfolgte standardisiert durch eine Analyse der prädefinierten Phasen 1–3.ErgebnisseFOI war beim Nachweis von Entzündung in PIP/DIP‐Gelenken sensitiver als der muskuloskelettale Ultraschall (MSUS) (p = 0,035). Bestätigte PsA‐Patienten hatten mehr Befunde in P2 und P3 der FOI, während Patienten mit Verdacht auf PsA mehr Befunde in P1 aufwiesen. In der Gruppe mit bestätigter PsA waren insbesondere die MCP‐Gelenke betroffen, während in der Gruppe mit Verdacht auf PsA mehr betroffene Handgelenke und DIP‐Gelenke (p = 0,006) mittels FOI nachgewiesen wurden.SchlussfolgerungenDie Unterschiede zwischen den Gruppen mit der bestätigten und der Verdachtsdiagnose lassen darauf schließen, dass die FOI für den Nachweis einer frühen PsA ein geeignetes Verfahren ist, da eine vermehrte Anreicherung in P1 am ehesten einer akuten Entzündung entspricht, während eine erhöhte Signalintensität in P2 und P3 eine chronische Entzündung widerspiegelt. Die fluoreszenzoptische Bildgebung könnte daher zukünftig als neues Verfahren in der frühen Diagnose einer PsA Bedeutung erlangen.
Entwicklung und Validierung eines Fragebogens zur Messung des Empowerments bei erwachsenen Patienten mit atopischer Dermatitis. Der DATEMP‐Fragebogen
Authors: Pereyra‐Rodriguez José Juan , Dominguez‐Cruz Javier Jesús , Hernandez‐Montoya Carlos , Galan‐Gutiérrez Manuel , Martín Carrasco Pablo , Alcántara Luna Sara , Navarro‐Triviño Francisco José , del Pozo Jesús , Ruiz‐Villaverde Ricardo 
Published: September 2019

ZusammenfassungHintergrund und ZieleIn den letzten Jahren gewann insbesondere bei chronischen Erkrankungen die Erkenntnis an Bedeutung, dass über eine Steigerung des Empowerments von Patienten das medizinische Outcome verbessert und der Einsatz von Gesundheitsleistungen rationalisiert werden kann. Die Entwicklung und Validierung von Messinstrumenten sind zur Verwirklichung dieses Ziels essenziell. In der Dermatologie haben sich nur wenige Studien mit dem Empowerment befasst. Ziel der vorliegenden Studie ist die Entwicklung und Validierung eines selbstauszufüllenden Fragebogens für erwachsene Patienten mit der Diagnose atopische Dermatitis (AD), um das Ausmaß ihres Empowerments zu bestimmen.MethodenNach Literaturrecherche und Einrichtung von Consulting‐Gruppen, bestehend aus Patienten und Dermatologen, wurde auf Grundlage der in früheren Empowerment‐Studien verwendeten Dimensionen ein Themenkomplex aus 35 Items erstellt. Eine multidisziplinäre Gruppe wählte daraus die 20 am besten geeigneten Items für den Fragebogen aus. Mit diesen Items sowie den demographischen und klinischen Charakteristika wurde eine Querschnittsstudie durchgeführt. Mit exploratorischer Faktorenanalyse (EFA) der primären Komponenten und Varimax‐Rotation wurde die Anzahl der Items verringert und die Konstruktvalidität bestimmt. Die Reliabilität der individuellen Skalen und des Fragebogens wurde mit Cronbachs α ermittelt.ErgebnisseEs wurden 242 gültige Fragebogen berücksichtigt. Nach der EFA bestand der endgültige Dermatitis Atópica EMPoderamiento (DATEMP)‐Fragebogen aus 17 Items, die in 4 Faktoren zusammenliefen. Die folgenden 4 Skalen hatten eine ausreichende Zuverlässigkeit: „Wissen“ (knowledge) (Cronbachs α = 0,808), „Fähigkeiten“ (abilities) (Cronbachs α = 0,744), „Wille zu Veränderungen“ (intention to change) (Cronbachs α = 0,798) und „Bewältigungsstrategien“ (coping skills) (Cronbachs α = 0,772). Insgesamt betrug der Cronbach‐α‐Wert des Fragebogens 0,764.SchlussfolgerungenDer DATEMP‐Fragebogen ist das erste spezifisch für Patienten mit AD entwickelte Messinstrument für Empowerment, bei dem eine ausreichende Reliabilität und Konstruktvalidität nachgewiesen wurde. Es handelt sich um einen selbstauszufüllenden Fragebogen, der leicht und schnell zu beantworten ist.
S2k‐Leitlinie zur Therapie der Psoriasis bei Kindern und Jugendlichen – Kurzfassung Teil 2
Authors: Eisert Lisa , Augustin Matthias , Bach Sabine , Dittmann Martin , Eiler Renate , Fölster‐Holst Regina , Gerdes Sascha , Hamm Henning , Höger Peter , Horneff Gerd , von Kiedrowski Ralph , Philipp Sandra , Pleimes Marc , Schlaeger Martin , Schuster Volker , Staubach Petra , Weberschock Tobias , Werner Ricardo Niklas , Nast Alexander , Sticherling Michael 
Published: September 2019

ZusammenfassungDiese Leitlinie richtet sich an Assistenz‐ und Fachärzte der Dermatologie, Pädiatrie, Kinderdermatologie und Kinderrheumatologie sowie an Kostenträger und politische Entscheidungsgremien. Die Leitlinie wurde im formellen Konsensusverfahren (S2k) von Dermatologen und Kinderdermatologen unter Einbindung von Kinderrheumatologen erstellt.Die Leitlinie stellt einen Überblick über Schweregrad, Lebensqualität und Therapieziele mit Erläuterung der Off‐Label‐Problematik im Kindesalter dar. Es werden Diagnosestellung und Triggerfaktoren erläutert. Der Schwerpunkt der Leitlinie liegt auf der Darstellung der verschiedenen topischen Therapien, UV‐Therapien und systemischen Therapieoptionen mit Abbildung der Empfehlungen zur Anwendung der Therapien sowie Therapiealgorithmen. Darüber hinaus wird im Kontext auf Impfungen bei Psoriasis im Kindesalter sowie auf verschiedene Sonderformen wie Psoriasis guttata, Windelpsoriasis, Psoriasis pustulosa und Psoriasisarthritis eingegangen. Auch werden Empfehlungen zu Tuberkulosediagnostik und Röntgenuntersuchung vor Systemtherapie gegeben.
Multidimensional stable isotope analysis illuminates resource partitioning in a sub‐Antarctic island bird community
Authors: Connan Maëlle , Dilley Ben J. , Whitehead T. Otto , Davies Delia , McQuaid Christopher D. , Ryan Peter G. 
Published: September 2019

A central theme in community ecology is understanding how similar species co‐exist and how their interactions may evolve in the context of climate change. Most studies of resource partitioning among central place foragers, particularly birds, focus on the offspring‐rearing period, when they are accessible, but breeding success may be determined earlier and little is known about how such species partition resources at the onset of breeding. We used a non‐invasive approach to evaluate resource partitioning in co‐existing females at a sub‐Antarctic island during their pre‐laying periods. Three hypotheses were tested using carbon, nitrogen and oxygen stable isotope ratios measured in shells and membranes of hatched eggs as ecological tracers: 1) resource partitioning by geographic location and trophic level will exist among the 12 bird species and will be enhanced within taxonomic groups; 2) given the absence of strong oxygen gradients in the Southern Ocean we will not detect spatial structuring based on oxygen isotopes, but differences will exist between resident and oceanic species as the former may use meteoric water; 3) capital and income breeder strategies can be differentiated using stable isotopes of egg remains.Two and three dimensional isotopic data showed resource partitioning among species. As predicted, segregation was evident within the four main taxonomic groups: penguins, albatrosses, burrowing petrels and giant petrels. Unexpectedly, oxygen isotopes revealed widespread use of meteoric water among a suite of sub‐Antarctic birds. Stable isotopes allowed us to identify females of most species as income breeders at the onset of breeding, with the exception of the females of the two crested penguin exhibiting a mix of income and capital resources use. Multidimensional isotopic analyses revealed that resource partitioning exists at multiple stages of the annual cycle in ways likely to be important under global change, exhibiting wide potential for ecosystem analysis.
Between Malthus and the industrial take‐off: regional inequality in Sweden, 1571–1850
Authors: Enflo Kerstin , Missiaia Anna 
Published: September 2019

AbstractThe causes and extent of regional inequality in the process of economic growth are at the core of historical economic research. So far, much attention has been devoted to studying the role of industrialization in driving regional divergence. However, empirical studies on relatively unequal countries such as Italy and Spain show that inequality was already high at the outset of modern industrialization. Using new estimates of Swedish regional GDP, this article looks for the first time at regional inequality in a pre‐industrial European economy. Its findings show that inequality increased dramatically between 1571 and 1750 and stayed high until the mid‐nineteenth century. This result refutes the classical view that the industrial take‐off was the main driver of regional divergence. Decomposing the Theil index for GDP per worker, we find that the bulk of inequality from 1750 onwards was driven by structural differences across sectors rather than different regional productivity within sectors. We show that counties with higher agricultural productivity followed a classic Malthusian pattern when experiencing technological advancement, while those with higher industrial productivity did not. We suggest that institutional factors, such as the creation of the Swedish Empire, Stockholm's trading rights, and a protective industrial policy, amplified this exceptional pattern.
Why do we feel bored with our clothing and where does it end up?
Authors: Kwon Theresa Anna , Choo Ho Jung , Kim Youn‐Kyung 
Published: September 2019

AbstractBoredom reflects the dynamic nature of consumer tastes and preferences. Understanding the role of boredom in clothing disposal is of particular importance given that consumers often dispose of clothes they feel bored with, leading to harmful environmental consequences. Despite its substantial influence on postacquisition behaviours, boredom has received insufficient attention in the disposal literature. In this paper, we explore the factors that lead to boredom and the effect of boredom on retention, recycling and discarding of clothing. We use a sequential mixed‐methods approach, consisting of a first qualitative phase that uses in‐depth interviews to generate hypotheses, followed by a second quantitative phase that tests the hypotheses using survey data. In two phases, we identify the oldness of clothing, decreased social fit and purchase of new clothing as drivers of boredom, which implies that the physical and aesthetic attributes of the clothing, social meaning ascribed to the clothing and situational factors collectively influence feelings of boredom towards owned clothing. As boredom intensifies, consumers are less inclined to keep the item and more inclined to recycle or discard it. Furthermore, we find that attachment and resource input (i.e., money, time and effort) moderate the effect of boredom on decisions regarding disposal methods. The results add to our understanding of emotion‐laden disposal by revealing the role of boredom in clothing disposal. Finally, our findings call for the collective efforts of consumers, retailers, campaigners and policymakers to break away from an increasingly extravagant and wasteful culture of clothing consumption.
Investigating volatile compounds’ contributions to the stale odour of green tea
Authors: Dai Qianying , Jin Huozhu , Gao Jing , Ning Jingming , Yang Xiaogen , Xia Tao 
Published: September 2019

SummaryThis study aimed to characterise the volatiles that contribute to stale odour of green tea. Volatiles were extracted using headspace solid‐phase microextraction (HS‐SPME) and analysed using gas chromatography‐mass spectrometry (GC‐MS) and gas chromatography‐olfactometry (GC‐O). Results showed that a total of ninety‐six volatiles were identified by GC‐MS, in which forty‐four volatiles were screened out based on Principal component analysis (PCA) and orthogonal projections to latent structures–discriminant analysis (OPLS‐DA), and thirty‐nine volatiles had a significant variation at the level of 0.05 by analysis of variance (anova). From GC‐O analysis, fifty‐four aromatic volatiles with strong aroma intensity (aroma intensity above 2) were perceived. Further investigation revealed that fifteen volatiles, including 1‐octen‐3‐ol, benzyl alcohol, benzaldehyde, safranal, β‐cyclocitral, (E,E)‐3,5‐octadien‐2‐one, (Z,E)‐3,5‐octadien‐2‐one, dimethyl adipate, dihydroactinidiolide, β‐ionone, α‐ionone, geranyl acetone, phenylethyl alcohol, methyl decanoate and α‐terpineol were responsible for stale odour, besides the former nine compounds were only found in stored tea.
Direct observation of the moisture distribution in calcium aluminate cement and hydratable alumina‐bonded castables during first‐drying: An NMR study
Authors: Barakat Ahmed J. , Pel Leo , Krause Olaf , Adan Olaf C. G. 
Published: September 2019

AbstractThe drying behavior for various calcium aluminate cement and hydratable alumina‐bonded refractory castables was investigated in the first‐drying temperature range (100°C‐300°C). Using a specialized high‐temperature Nuclear Magnetic Resonance setup, we were able to directly and nondestructively measure the spatially and temporally resolved moisture distribution, while simultaneously measuring the temperature distribution as well. These measurements show that the drying front position is a linear function of time, which can be explained on the basis of a simplified model where only vapor transport is considered. Based on the measurements and the model, one can directly determine the permeability at high temperatures. Moreover, the results demonstrate that the drying front speed and temperature strongly correlates with the control of key material parameters (eg, water demand, binder content, etc). In particular, microsilica fume‐containing low‐cement castables displayed the highest vapor pressures, while regular castables generated the lowest vapor pressures reflecting the permeability of these materials.
Modelling time‐varying low‐temperature‐induced mortality rates for pupae of Tuta absoluta (Gelechiidae, Lepidoptera)
Authors: Kahrer Andreas , Moyses Anna , Hochfellner Lisa , Tiefenbrunner Wolfgang , Egartner Alois , Miglbauer Teresa , Müllner Katharina , Reinbacher Lara , Pilz Christina , Votzi Julia , Scheifinger Helfried 
Published: September 2019

AbstractIn a series of laboratory experiments, acclimated pupae of Tuta absoluta were exposed to various constant low temperatures in order to estimate their maximum survival times (Kaplan–Meier, Lt99.99). A Weibull function was fitted to the data points, describing maximum survival time as a function of temperature. In another experiment at −6°C, the progress of mortality increasing with exposure time was identified. These values were fitted by a sigmoidal function converging asymptotically to 100% mortality for very long exposure times. Analysing mortality data from the maximum survival experiment by a generalized linear model showed a significant common slope parameter (p < .001) that reveals parallelism of the survival curves at each temperature if a log time axis is used. These curves appear stretched (time scaled) if plotted with a nonlogarithmic time axis. By combining these mathematical relations, it was possible to calculate a species‐specific ‘mortality surface’ which exhibits mortalities, depending on temperature and duration of exposure. In order to accumulate hourly mortalities for courses of varying temperatures, an algorithm was developed which yields mortality values from that surface taking into account the attained mortality level. In validation experiments, recorded mortalities were compared against modelled mortalities. Prediction of mortality was partially supported by the model, but pupae experiencing intensely fluctuating temperatures showed decreased mortality, probably caused by rapid cold hardening during exposure. Despite this observation, mortality data converged to distinct levels very close to 100% depending on the intensity of temperature fluctuations that were characteristic for different types of experiments. The highest mortality limit occurred at intensely fluctuating temperatures in laboratory experiments. This constituted a benchmark that was not reached under various field conditions. Thus, it was possible to identify temperature limits for the extinction of field populations of Tuta absoluta pupae.
Does audit report information improve financial distress prediction over Altman's traditional Z‐Score model?
Authors: Muñoz‐Izquierdo Nora , Laitinen Erkki K. , Camacho‐Miñano María‐del‐Mar , Pascual‐Ezama David 
Published: September 2019

AbstractWe analyze empirically the usefulness of combining accounting and auditing data in order to predict corporate financial distress. Concretely, we examine whether audit report information incrementally predicts distress over a traditional accounting model: the Altman's Z‐Score model. Although the audit report seems to play a critical part in financial distress prediction because auditors should warn investors about any default risks, this is the first study that uses audit report disclosures for predicting purposes. From a dataset of 1,821 Spanish distressed private firms, we analyze a sample of distressed and non‐distressed firms and develop logit prediction models. Our results show that while the only accounting model registers a classification accuracy of 77%, combined models of accounting and auditing data exhibit considerably higher accuracy (about 87%). Specifically, our findings indicate that the number of disclosures included in the audit report, as well as disclosures related to a firm's going concern status, firms’ assets, and firms’ recognition of revenues and expenses contribute the most to the prediction. Our empirical evidence has implications for financial distress practice. For managers, our study highlights the importance of audit report disclosures for anticipating a financial distress situation. For regulators and auditors, our study underscores the importance of recent changes in regulation worldwide intended to increase auditor's transparency through a more informative audit report.
Effects of the presence and absence of amino acids on translation, signaling, and long‐term depression in hippocampal slices from Fmr1 knockout mice
Authors: Cooke Spencer K. , Russin Jacob , Moulton Kristen , Nadel Jeffrey , Loutaev Inna , Gu Qinhua , Li Zheng , Smith Carolyn Beebe 
Published: September 2019

AbstractFragile X syndrome (FXS) is caused by silencing of the FMR1 gene and consequent absence of its protein product, fragile X mental retardation protein (FMRP). FMRP is an RNA‐binding protein that can suppress translation. The absence of FMRP leads to symptoms of FXS including intellectual disability and has been proposed to lead to abnormalities in synaptic plasticity. Synaptic plasticity, protein synthesis, and cellular growth pathways have been studied extensively in hippocampal slices from a mouse model of FXS (Fmr1 KO). Enhanced metabotropic glutamate receptor 5 (mGluR5)‐dependent long‐term depression (LTD), increased rates of protein synthesis, and effects on signaling molecules have been reported. These phenotypes were found under amino acid starvation, a condition that has widespread, powerful effects on activation and translation of proteins involved in regulating protein synthesis. We asked if this non‐physiological condition could have effects on Fmr1 KO phenotypes reported in hippocampal slices. We performed hippocampal slice experiments in the presence and absence of amino acids. We measured rates of incorporation of a radiolabeled amino acid into protein to determine protein synthesis rates. By means of western blots, we assessed relative levels of total and phosphorylated forms of proteins involved in signaling pathways regulating translation. We measured evoked field potentials in area CA1 to assess the strength of the long‐term depression response to mGluR activation. In the absence of amino acids, we replicate many of the reported findings in Fmr1 KO hippocampal slices, but in the more physiological condition of inclusion of amino acids in the medium, we did not find evidence of enhanced mGluR5‐dependent LTD. Activation of mGluR5 increased protein synthesis in both wild type and Fmr1 KO. Moreover, mGluR5 activation increased eIF2α phosphorylation and decreased phosphorylation of p70S6k in slices from Fmr1 KO. We propose that the eIF2α response is a cellular attempt to compensate for the lack of regulation of translation by FMRP. Our findings call for a re‐examination of the mGluR theory of FXS.
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Influence of perioperative stress on central and peripheral oxytocin and arginine‐vasopressin concentrations
Authors: Kagerbauer Simone Maria , Martin Jan , Ulm Bernhard , Jungwirth Bettina , Podtschaske Armin Horst 
Published: September 2019

AbstractPerioperative stress provides not only physical, but also psychic and emotional aspects, which may influence the hypothalamic neuropeptide system. Studies investigating the perioperative course of central neuropeptide activity are missing. Therefore, the present study aimed to determine perioperative fluctuations in central and concomitant peripheral concentrations of the hypothalamic neuropeptides oxytocin (OXT) and arginine‐vasopressin (AVP), as well as their impact on perioperative anxiety and depression. Cerebrospinal fluid (CSF), blood and saliva were collected from 12 patients who underwent elective endovascular aortic repair with a routinely inserted spinal catheter. AVP and OXT concentrations were analysed at four timepoints: (i) the evening before the operation; (ii) the operation day immediately before anaesthesia induction; (iii) intraoperatively after the stent was placed; and (iv) on day 1 after the operation. Patients completed the Hospital Anxiety and Depression Scale (HADS) at timepoints 1 and 4. For CSF OXT, the present study showed a significant intraoperative decline, accompanied by a decrease in saliva. OXT blood concentrations before anaesthesia induction were higher than at the evening before the operation. OXT concentrations in CSF and saliva correlated well at timepoints 2‐4. AVP concentrations in CSF, blood and saliva did not show any significant changes perioperatively. However, postoperative AVP blood concentrations showed a significant negative correlation with anxiety and depression scores according to the HADS. This pilot study demonstrates perioperative fluctuations in central OXT concentrations, which are better reflected by saliva than by blood. Further studies are required to determine whether OXT and AVP can predict postoperative post‐traumatic stress disorder.
Distributive politics of public goods networks through multistage voting
Authors: Kurosaka Kengo 
Published: September 2019

AbstractPublic goods networks create conflict between districts needing the network and districts that pay the costs. Thus, it is difficult for pork barrel politicians to achieve logrolling with other districts. I show that logrolling is possible for such politicians if they set their agenda properly. To show this, I model the centralized decision‐making process as a multistage vote among representatives from different districts. I assume the districts are better off if and only if the public good “connects” them to the network. Public goods can be provided universally by setting the agenda properly, even when costs exceed the benefits.