bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proximity Ligation‐Based Fluorogenic Imaging Agents for Neuraminidases
Authors: Gao Zhizeng , Thompson Andrew J. , Paulson James C. , Withers Stephen G. 
Published: September 2018

AbstractReagents to visualize and localize neuraminidase activity would be valuable probes to study the role of neuraminidases in normal cellular processes as well as during viral infections or cancer development. Herein, a new class of neuraminidase‐imaging probes that function as proximity ligation reagents by releasing a highly reactive fluorophore that tags nearby cellular material is described. It is further demonstrated that it is possible to create an influenza virus‐specific reagent, which can specifically detect influenza virus infections in mammalian cells. These reagents have potential use as specific histological probes independent of viral antigenicity and, therefore, offer some advantages over commonly used anti‐neuraminidase antibodies.
Dynamic Migration of Surface Fluorine Anions on Cobalt‐Based Materials to Achieve Enhanced Oxygen Evolution Catalysis
Authors: Chen Pengzuo , Zhou Tianpei , Wang Sibo , Zhang Nan , Tong Yun , Ju Huanxin , Chu Wangsheng , Wu Changzheng , Xie Yi 
Published: September 2018

AbstractFluorine‐anion surface engineering has now been used to activate catalytic active species, representing a completely new way of reconstruction toward oxygen evolution reaction (OER) active species. The electronegativity of the fluorine anion is the strongest so that it will be much easier to form weak metal–fluorine bonds with stronger ionicity, contributing to the dynamic migration of fluorine anions and finally enriching on the surface of both cobalt‐based oxide/oxyhydroxide. Surface enrichment of fluorine anions endows more hydrophilic surface character for accelerating the key process of oxygen‐related intermediate adsorption. Combining with an obviously improved electron transfer capacity, the F‐CoOOH/NF catalyst exhibits a greatly enhanced OER activity (270 mV at 10 mA cm−2) and reaction kinetics (54 mV dec−1) in alkaline medium. Surface anion engineering introduces a new concept for rational design advanced OER catalysts for energy conversion system.
Development of a highly accurate and sensitive diagnostic tool for pyrethroid‐resistant chimeric P450 CYP337B3 of Helicoverpa armigera using loop‐mediated isothermal amplification
Authors: Choi Bo Hey , Hur Joon Haeng , Heckel David G. , Kim Juil , Koh Young Ho 
Published: September 2018

AbstractRecent studies have shown that pyrethroid resistance in the cotton bollworm (CBW) Helicoverpa armigera is conferred by the generation of a chimeric CYP337B3 gene, which resulted from unequal crossing‐over between the CYP337B1 and CYP337B2 genes. In this study, we developed a diagnostic protocol based on the loop‐mediated isothermal amplification (LAMP) assay for the detection of chimeric CYP337B3. The CYP337B3 LAMP assay utilized six primers and generated strong fluorescence signals visible to the naked eye under normal or ultraviolet light. The primers were designed based on CYP337B3v1 (JQ995292), the major allele detected in Australia. The detection limit of this LAMP assay was 10 fg genomic DNA in a 25‐µl reaction mixture. Compared with CYP337B2v1, the Korean CYP337B3v2 allele had two nucleotide mismatches within the amplifying regions of this LAMP assay; therefore, we confirmed that polymerase chain reaction‐synthesized CYP337B3v2 was well amplified using this LAMP assay. In addition, we determined that the presence of CYP337B3 from H. armigera collected by pheromone traps from Korean fields could be confirmed using this LAMP assay. This assay could detect CYP337B3 even in heterozygotes, which is relevant because CYP337B3 is dominant, and heterozygotes are pyrethroid resistant. Therefore, the newly developed CYP337B3 LAMP assay could detect the presence of pyrethroid resistance in H. armigera that were captured by pheromone traps during the early season and provide information on whether pyrethroids could be used to control H. armigera.
Tunable Fluorescence from a Responsive Hyperbranched Polymer with Spatially Arranged Fluorophore Arrays
Authors: Cao Xiaosong , Gan Weiping , Shi Yi , Xu Hui , Gao Haifeng 
Published: September 2018

AbstractIn the present study, a water‐soluble hyperbranched polymer platform that contained a Förster resonance energy transfer (FRET) array and exhibited varied fluorescence in response to solvent, light, and CN− anion stimuli was constructed. The use of chain‐growth copper‐catalyzed azide–alkyne cycloaddition polymerization (CuAACP) enabled accurate control of the ratio and distance of three incorporated fluorophores, coumarin (Cou), nitrobenzoxadiazole (NBD), and photoswitchable spiropyran (SP), that could be reversibly transformed into the red‐emitting merocyanine (MC) state. Within the FRET system, the energy flow from Cou to MC was significantly enhanced by the introduction of NBD as a central fluorophore relay. Moreover, the energy‐transfer efficiency was increased by changing the solvent from tetrahydrofuran to more polar water; this was accompanied by a clear color change and fluorescence behavior. These correlations of polymer composition and solvent polarity to the FRET efficiency were finally applied to the effective detection of CN− anion; thus demonstrating a function of this polymer as a CN− sensor.
Deadlock and Blockage Control of Automated Manufacturing Systems with an Unreliable Resource
Authors: Luo JianChao , Xing KeYi , Zhou MengChu 
Published: September 2018

AbstractThis work studies the deadlock and blockage control problem of an automated manufacturing system (AMS) with a single unreliable resource. It aims to develop a robust control policy to ensure that AMS can produce all parts in the absence of resource failures, and when the unreliable resource fails, the system can continuously produce all parts that do not require the failed resource. To this end, we divide the system into two regions, continuous and non‐continuous, based on whether all parts in them can be produced continuously or not. For the non‐continuous region, dominating region constraints are established to ensure that all parts in it do not block the production of parts in the continuous region, and an optimal deadlock avoidance policy based on a Petri net model is introduced to guarantee its deadlock‐free operation. For the continuous region, we configure a resource order policy to ensure the smooth productions of AMS. By integrating the dominating region constraints and deadlock avoidance policy with the configured resource order policy, we propose a novel robust control policy. It is proven to be of polynomial complexity and more permissive than the existing one with the same resource order policy. Also, it is tested to be more permissive than other existing policies.
H∞ Filtering for Spatially Interconnected Time‐Delay Systems with Interconnected Chains in Finite Frequency Domains
Authors: Wang Guopeng , Xu Huiling , Zhang Guizhou , Yao Juan 
Published: September 2018

AbstractThis paper deals with the problem of delay‐dependent H∞ filtering for spatially interconnected time‐delay systems (SITSs) with interconnected chains in finite frequency domains. First, a multidimensional (N‐D) hybrid time‐delay Roesser model and a delay‐dependent finite frequency bounded ream lemma (BRL) for SITSs with interconnected chains are proposed. Then, using the obtained delay‐dependent finite frequency BRL, a finite frequency H∞ filter design method can be derived by solving a set of linear matrix inequalities (LMIs). Finally, a practical example is provided to clearly demonstrate the effectiveness of the proposed method.
Reduced distractor interference in neurotypical adults with high expression of autistic traits irrespective of stimulus type
Authors: Muller Spaniol Mayra , Shalev Lilach , Mevorach Carmel 
Published: September 2018

Attention atypicality is evident in autism spectrum disorder (ASD) and its broader phenotype with previous studies suggesting that in some cases participants can be more efficient at ignoring distracting irrelevant information. However, it is not clear to what extent this improved filtering capacity is driven by perceptual atypicality, such as local bias or atypical face processing, which is also sometimes reported in these populations. For instance, better ability to ignore the global aspect of a display could stem from a local perceptual bias rather than from improved distractor inhibition. To test whether distractor suppression per se, is associated with high expression of autistic traits, in the present study a large cohort of neurotypical participants (n = 218), in whom expression of autistic traits was assessed, performed two nonspatial attention selection tasks with different categories of stimuli (global/local and face/scene). Importantly, both tasks involved a conflict with one aspect of the stimuli designated as the target and the other designated as the distractor. Across the two experiments adults with high autistic traits were overall, better able to ignore distractors than adults with low autistic traits, irrespective of the type of perceptual processing involved. These results support the notion that autistic tendencies are associated with increased attention filtering (at least when target and distractor remain constant) which is not dependent on perceptual biases. Thus, future work in the broader autism phenotype should explicitly consider the effect played by attention mechanisms in this population. Autism Res 2018, 11: 1345–1355. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryIn the present study, we show that neurotypical adults with high autistic traits are better able to avoid distraction from conspicuous (but completely irrelevant) distractors when told in advance to do so. This ability is not affected by the type of visual input (for instance, whether the distractor is a face or whether small rather than large letters should be reported). This finding could be important in better understanding the way attention is utilized in Autism.
Hyperplastic Response Following Soft Tissue Augmentation in the Esthetic Zone
Authors: Gluckman Howard , Du Toit Jonathan , Pontes Carla Cruvinel , Hille Jos 
Published: September 2018

IntroductionThe indications for augmentation of gingival tissue by connective tissue graft (CTG) are numerous. The techniques are widely adopted with extensive literature reporting high success. Harvest techniques include the mid to anterior palate, versus the posterior palate and tuberosity. The latter comprises denser collagen, identified as a more suitable graft. Alas, rarely have hyperplastic responses been reported.Case PresentationTwo adult, Caucasian patients presented with clinical need for soft tissue augmentation. Autogenous tissue was opted for, harvesting from the tuberosity gingiva. De‐epithelialized outside the mouth and inserted into envelope flaps, late healing resulted in hyperplastic gingival lesions. Neither lesion could be successfully removed, and biopsy for histopathological investigation was carried out.ConclusionHyperplastic response resulting from soft tissue augmentation with tuberosity CTG is rare but may occur. Laser or scalpel might not ensure complete removal. Informing the patient of this rare adverse effect may be important.
The prevalence of computed tomography‐defined leaflet thrombosis in intra‐ versus supra‐annular transcatheter aortic valve prostheses
Authors: Rashid Hashrul N. , Nasis Arthur , Gooley Robert P. , Cameron James D. , Brown Adam J. 
Published: September 2018

AbstractIntroductionLeaflet thrombosis (LT) defined by computed tomography (CT) following transcatheter aortic valve replacement (TAVR) has been shown to increase cerebrovascular events. The neo‐sinus plays an important role in the development of LT. Intra‐annular valves (IAV) have a larger neo‐sinus when compared to supra‐annular valves (SAV), and has been associated with larger thrombus burden. The prevalence of LT with IAV and SAV in a larger, diverse cohort is unknown.MethodsWe performed a systematic review to assess the prevalence of LT in IAV versus SAV TAVR prostheses. Inclusion criteria were (1) reported CT‐defined LT following TAVR, (2) comparison between LT and non‐LT cohort, (3) separate registry/database, and (4) fully published status. A total of 2,013 citations were reviewed and 7 studies were included.ResultsOverall, 1,644 patients were included from 7 observational studies and the prevalence of LT following TAVR was 12.8%. The Portico valve system (IAV) had the highest prevalence of LT with 35.2%, followed by Symetis Acurate Neo (SAV) at 15.4% and the Lotus valve system (IAV) at 14.5%. LT occurred more frequently in IAV than SAV (13.5% vs. 7%, P = 0.02). Subanalysis of IAV versus SAV with the exclusion of the Portico valve was performed to ensure results were not influenced by this valve system and revealed IAV still had higher rates of LT (12.1% vs. 7%, P = 0.05).ConclusionIn summary, IAV prostheses appear to be associated with higher rates of LT when compared with SAV.
Retracted: Chemoenzymatic Method for Enantioselective Synthesis of (R)‐2‐Phenylglycine and (R)‐2‐Phenylglycine Amide from Benzaldehyde and KCN Using Difference of Enzyme Affinity to the Enantiomers
Authors: Kawahara Nobuhiro , Asano Yasuhisa 
Published: September 2018

AbstractIn general, enzymatic and chemoenzymatic methods for asymmetric synthesis of α‐amino acids are performed using highly enantioselective enzymes. The enzymatic reactions using α‐aminonitrile as a starting material have been performed using reaction conditions apart from the chemical Strecker synthesis. We developed a new chemoenzymatic method for the asymmetric synthesis of α‐amino acids from aldehydes and KCN by performing Strecker synthesis and nitrilase reaction in the same reaction mixture. Nitrilase AY487533 that showed rather low enantioselectivity in hydrolysis of 2‐phenylglycinonitrile (2PGN) to 2‐phenylglycine (2PG) was utilized in the hydrolysis of aminonitrile formed from benzaldehyde and KCN via 2PGN by Strecker synthesis, preferentially synthesizing (R)‐2PG with more than 95 % yield and enantiomeric excess (ee). The method was also utilized for the synthesis of (R)‐2‐phenylglycine amide ((R)‐2PGNH2) from benzaldehyde and KCN by the chemoenzymatic reaction in the presence of a mutated nitrilase AY487533W186A, which catalyzes the conversion of 2PGN to 2PGNH2.
Phosphorescent Cyclometalated Platinum(II) aNHC Complexes
Authors: Soellner Johannes , Strassner Thomas 
Published: September 2018

AbstractThe synthesis and characterization of the first bidentate C^C* cyclometalated platinum(II) complexes based on abnormal N‐heterocyclic carbenes (aNHC) is presented. The aNHC ligand precursors are prepared from benzonitriles and anilines to form 1,2,3‐trisubstituted imidazolium salts. The title compounds were synthesized by in situ generation of the silver carbene complex, followed by transmetalation to platinum and subsequent introduction of the β‐diketonate ligand. Structural characterization by 2D NMR experiments, as well as solid‐state structures unequivocally prove the abnormal binding mode of the aNHC ligands. Additionally, the photophysical properties of the platinum(II) complexes were examined and studied in detail by DFT calculations and cyclic voltammetry experiments. The title compounds proved to be strongly emissive at room temperature in the green to orange region of the visible spectrum, with emission efficiencies of up to 69 %.
On Jeff=0 Ground State Iridates(V): Tracking Residual Paramagnetism in New Bi2NaIrO6
Authors: Prasad Beluvalli E. , Doert Thomas , Felser Claudia , Jansen Martin 
Published: September 2018

AbstractOpen‐shell transition metal oxides are capable of developing a rich diversity of electronic phases. The specific features evolving crucially depend on an intricate interplay of various local and long‐range electronic interactions. Recently, the 5d transition elements have come into sharp focus because for these elements spin‐orbit coupling (SOC) and onsite Coulomb repulsion (U) are on a comparable energy scale. For Ir4+ the t2g level associated to an octahedral crystal field (CF) is split by SOC, giving rise to a Jeff=
spin state and rendering respective oxides like Sr2IrO4 as Mott insulators. Transferring this scenario to iridium(V) oxides would lead to a diamagnetic ground state, Jeff=0. However, reported experimental results do not lend unambiguous support for such an electronic state. Theoretical explanations for the breakdown of the J=0 magnetic state suffer from conspicuous discrepancies. In an attempt to empirically contribute to resolving the puzzle, Bi2NaIrO6 was synthesized in high purity by precipitation from homogeneous solution; it represents an iridium(V) oxide where long range band structure effects and magnetic superexchange are minimized, and the t2g degeneracy is lifted geometrically. We managed to reduce the strength of paramagnetic response, lending support to a Jeff=0 ground state of Bi2NaIrO6, exhibiting van Vleck type behavior.
Tabletop 700 MHz electron paramagnetic resonance imaging spectrometer
Authors: Buchanan Laura A. , Rinard George A. , Quine Richard W. , Eaton Sandra S. , Eaton Gareth R. 
Published: September 2018

AbstractLow frequency electron paramagnetic resonance imaging is a powerful tool to noninvasively measure the physiological status of tumors. Here, we report on the design and functionality of a rapid scan and pulse tabletop imaging spectrometer based around an arbitrary waveform generator and 25 mm cross‐loop resonator operating at 700 MHz. Two and four‐dimensional rapid scan spectral‐spatial images are presented. This tabletop imager is a prototype for future preclinical imagers.
Oncologist volume and outcomes in older adults diagnosed with diffuse large B cell lymphoma
Authors: Huntington Scott F. , Hoag Jessica R. , Zhu Weiwei , Wang Rong , Zeidan Amer M. , Giri Smith , Podoltsev Nikolai A. , Gore Steven D. , Ma Xiaomei , Gross Cary P. , Davidoff Amy J. 
Published: September 2018

BackgroundAlthough provider‐level volume is frequently associated with outcomes in cancers requiring complex surgeries, whether similar relations exist for cancers treated primarily with systemic therapy is unknown.MethodsUsing a population‐based cohort analysis of older adults diagnosed with diffuse large B cell lymphoma (DLBCL) during the years 2004‐2011, we evaluated the association between oncologist volume and 4 clinical outcomes (receipt of any chemotherapy, receipt of an anthracycline‐containing or equivalent regimen, early hospitalization, and overall survival). Our primary explanatory variable was lymphoma treatment volume, defined as the number of patients with newly diagnosed lymphoma for which an oncologist initiated therapy during a 12‐month look‐back period from each incident DLBCL case.ResultsWe identified 8247 Medicare beneficiaries who were newly diagnosed with DLBCL. Chemotherapy was administered to 6202 (75.2%) beneficiaries, and 71.4% of cytotoxic regimens contained an anthracycline. Beneficiaries who were treated by higher‐volume oncologists had increased odds of receiving chemotherapy (adjusted odds ratio [aOR], 1.45; 95% confidence interval [CI], 1.24‐1.70; P <.001) and of receiving an anthracycline‐containing regimen (aOR, 1.26; 95% CI, 1.06‐1.50; P = .009). Receiving care from a higher‐volume provider was also associated with decreased hospitalization (aOR, 0.80; 95% CI, 0.69‐0.95; P = .007) and improved survival (adjusted hazard ratio, 0.85; 95% CI, 0.79‐0.92; P < .001).ConclusionIn older adults diagnosed with DLBCL, receiving care from a provider with more experience treating lymphoma patients was associated with receipt of guideline‐adherent therapy, reduced hospitalizations, and improved survival. Clinical volume may be an important factor in providing high‐quality cancer care in the modern era.
An optimized procedure to develop a 3‐dimensional microfluidic hydrogel with parallel transport networks
Authors: Jafarkhani Mahboubeh , Salehi Zeinab , Shokrgozar Mohammad Ali , Mashayekhan Shohreh 
Published: September 2018

AbstractThe development of microfluidic hydrogels is an attractive method to generate continuous perfusion, induce vascularization, increase solute delivery, and ultimately improve cell viability. However, the transport processes in many in vitro studies still have not been realized completely. To address this problem, we have developed a microchanneled hydrogel with different collagen type I concentrations of 1, 2, and 3 wt% and assessed its physical properties and obtained diffusion coefficient of nutrient within the hydrogel. It is well known that microchannel geometry has critical role in maintaining stable perfusion rate. Therefore, in this study, a computational modeling was applied to simulate the 3D microfluidic hydrogel and study the effect of geometric parameters such as microchannel diameters and their distance on the nutrient diffusion. The simulation results showed that the sample with 3 channels with a diameter of 300 μm has adequate diffusion rates and efficiency (56%). Moreover, this system provides easy control and continuous perfusion rate during 5 days of cell culturing. The simulation results were compared with experimental data, and a good correlation was observed for nutrient profiles and cell viability across the hydrogel.
Retracted: Application of VR computer image technology in 3D virtualization of sports human science
Authors: Cheng Yuan 
Published: September 2018

SummaryCompared with traditional geometric modeling techniques, image‐based modeling technology has the advantages of simple operation, quick reconstruction, and strong sense of reality. Compared with the three‐dimensional scanning technology, it has the characteristics of low cost and simple algorithm. In a broad sense, the image‐based 3D modeling technique not only includes the geometric modeling of the entity but also includes visual restoration, ie, reconstruction of the geometric model of the entity using the image, and restoration of its corresponding surface texture, reflection properties, lighting conditions, and the like. This paper focuses on the application of geometric reconstruction methods to study the application of VR computer images in the three‐dimensional virtualization of sports human science. By combining the background difference method and the interframe difference method, the target region where the moving human body is located can be accurately extracted from the video, and then the idea of the human body can be divided along the virtual plane. Finally, the end‐point feature points of the human body are determined by the geodesic distance, and a three‐dimensional model skeleton is buried using a discrete penalty function, and an image‐based three‐dimensional reconstruction system is realized.