bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of urinary PAHs on psoriasis risk in U.S. adults: Insights from NHANES
Authors: Li Jiang-Hui , Yan Xiao-Ning , Fu Jia-Ying , Hu Hao-Yuan 
Published: December 2024

Objective
Exposure to environmental pollutants is increasingly recognized as a risk factor for the development of psoriasis. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the air and might induce reactions such as oxidative stress. Nevertheless, it is still unclear if PAHs have any influence on the prevalence of psoriasis over the entire population of the United States. The objective of this study was to assess the association between urine PAHs and psoriasis.

Methods
The research included 3,673 individuals aged 20 years or older who participated in the 2003–2006 and 2009–2012 National Health and Nutrition Examination Surveys (NHANES). We employed logistic regression models to evaluate the relationship between levels of urine PAH metabolites and psoriasis and smoothed curve fitting to illustrate the concentration-response relationship. Additionally, subgroup and interaction analyses were conducted to elucidate these associations. Furthermore, we employed weighted quartile sum (WQS) regressions to examine the distinct effects of individual and mixed urine PAH metabolites on psoriasis. However, it is important to note that the NHANES sample may be subject to selectivity and self-reporting bias, which may influence the data’ generalisability.

Results
We observed that the highest tertiles of 2-NAP and 2-FLU had a 63% (95% CI 1.02, 2.61) and 83% (95% CI 1.14, 2.96) higher odds of association with psoriasis prevalence, respectively. Meanwhile, tertile 2 and tertile 3 of 3-PHE were also significantly associated with psoriasis, with higher odds of 65% (95% CI 1.01, 2.69) and 14% (95% CI 1.17, 3.00), respectively. The subgroup analyses revealed a significant correlation between urine PAH metabolites and the odds of psoriasis in specific groups, including males, aged 40–60 years, with a BMI > 30, and those with hyperlipidemia. In the WQS model, a positive association was found between the combination of urine PAH metabolites and psoriasis (OR 1.43, 95% CI 1.11, 1.84), with 2-FLU being the most prevalent component across all mixtures (0.297).

Conclusions
Our findings indicate a significant association between urine PAH metabolites and the odds of psoriasis prevalence in adults. Among these metabolites, 2-FLU demonstrated the most prominent impact. Controlling PAH exposure, as an important strategy for minimizing exposure to environmental contaminants and lowering the risk of psoriasis, is critical for raising public knowledge about environmental health and preserving public health.
Understanding the relationships between 24-hour movement behavior, community mobility and the neighborhood built environment for healthy aging in Brazil: The EpiMove study protocol
Authors: Zorzi Viviane Nogueira de , Coelho Janio Carlos Pessanha , Santos Carla Elane Silva dos , Siqueira Junior Joel de Almeida , Scheller Daniel Alexander , d ‘Orsi Eleonora , Rech Cassiano Ricardo 
Published: December 2024

Background
The population is aging rapidly worldwide, impacting public health, with countries in the Global South, such as Brazil, aging faster than developed nations. The 24-hour movement behavior is crucial for healthy aging, but its relationship with the neighborhood built environment is underresearched, especially for older adults. The EpiMove Study uses accelerometers and GPS to investigate the relationships between 24-hour movement behavior, community mobility and the neighborhood built environment for healthy aging in older Brazilian adults.

Methods
The EpiMove Study is a representative cross-sectional study of older adults aged 60 years and older from an urban area in the southern region of Brazil. It consists of two phases. Phase 1 involves conducting home interviews to gather subjective measures of the neighborhood built environment and physical activity. Phase 2 involves delivering devices to participants’ homes and collecting objective data on 24-hour movement behavior via wrist-worn wGT3X-BT ActiGraph accelerometers and community-based active transportation via hip-mounted GPS Qstarz-1000XT devices. The data are collected simultaneously over seven consecutive days, along with the participants’ reasons for adhering to the study protocol.

Discussion
The EpiMove study will provide a better understanding of the relationships between the perceived neighborhood environment and 24-hour movement behaviors and community-based active transportation among older adults, with a particular focus on whether environmental factors influence these behaviors, which are crucial for healthy aging. The results from the EpiMove study could offer essential evidence for developing public policies and urban interventions that support healthier and more equitable environments for aging populations, particularly in rapidly urbanizing regions.
Comparing effects of wearable robot-assisted gait training on functional changes and neuroplasticity: A preliminary study
Authors: Lee Jungsoo , Kunanbayev Kassymzhomart , Jang Donggon , Kim Dae-Shik 
Published: December 2024

Robot-assisted gait training (RAGT) is a promising technique for improving the gait ability of elderly adults and patients with gait disorders by enabling high-intensive and task-specific training. Gait functions involve multiple brain regions and networks. Therefore, RAGT is expected to affect not just gait performance but also neuroplasticity and cognitive ability. The purpose of this preliminary study was to verify the feasibility of the proposed RAGT design and to assess and compare the effect sizes of various measurement variables, including physical, cognitive, and neuroimaging induced by RAGT. Twelve healthy adults without any neurological or musculoskeletal disorders participated in this study. All participants wore a wearable exoskeleton robot and underwent 10 RAGT sessions. Functional data related to physical and cognitive abilities and neuroimaging data obtained from a magnetic resonance imaging (MRI) scanner and a functional near-infrared spectroscopy (fNIRS) device were acquired before and after the training sessions to assess the effect sizes of variables affected by RAGT. All participants underwent 10 sessions of RAGT without any adverse incidents, and the feasibility of the proposed RAGT design, consisting of preferred speed walking, fast speed walking, inclined walking, and squats, was validated. Variables related to physical and cognitive abilities significantly improved, but those related to neuroplasticity did not. The effect size of physical ability was “very large,” whereas that of cognitive ability was “medium-to-large.” The effect sizes of functional and structural neuroplasticity showed “medium” and “very small,” respectively. The effect size of the RAGT varied depending on the measured variables, with the effect size being the greatest for physical ability, followed by cognitive ability, functional neuroplasticity, and structural neuroplasticity. The proposed RAGT design affects cognitive and neuroplastic effects beyond the physical effect directly affected by RAGT. This study highlights that while RAGT can positively influence cognitive outcomes beyond physical benefits, more intensive interventions may be required to elicit significant neuroplastic changes. This preliminary study offers useful information for researchers interested in designing robot-assisted training by investigating the potential extent of neuroplastic effects.
Trial registration: KCT0006738.
Archives and Research: Situating the Reading Experience
Authors: Brasch Ilka 
Published: December 2024

Abstract
The main premise of this article is that research conducted on site in archival reading rooms is influenced by the architecture of an archive and the interior design of its reading room. A subjective account of the study of the publication, editorial, and material histories of early-American literature at the American Philosophical Society and the Library Company in Philadelphia illustrates how the engagement with books in an archive is marked by an arrest of time. An empty sense of history in reading rooms as well as ritualized procedures of entry into library spaces and a supervised reading experience, in addition to a calming environment, inform this temporal suspension. A comparable sense of arrest marks the archival document itself, which is shielded from accumulating marks or additions that would bear evidence of its history after it entered the archive. A similar bracketing of time informs the archive as an institution, which provides a nation with a moment of origin.
Coleridge’s Surrogate: An Inquiry into the Identity of the Glossist of The Rime of the Ancient Mariner (1817)
Authors: Mei Shenyou 
Published: December 2024

Abstract
The writer of the marginal gloss of The Rime of the Ancient Mariner (1817) has long been viewed by critics as an imaginary editor obsessed with dry rational analysis and pedantic moral teaching while being incapable of imagination and emotion, totally different from the poet. This essay first queries this notion and, by examining some key gloss passages, demonstrates that the glossist is at times capable of extraordinary empathy. The glossist’s ability to combine reason and emotion is a telling testament to Coleridge’s idea of how to be a qualified reader. Given the fact that Coleridge was a voracious reader of antiquarian books and habitual writer of marginalia, the paper posits that the glossist bears strong resemblance to the poet. The poem’s gloss passages can be regarded as Coleridge’s tacit practice of marginalia in a deliberate effort to illustrate this obscure and often misunderstood poem. The glossist’s resort to Neoplatonic machinery and Christian preaching is attributable to Coleridge’s philosophical and theological stance as a Christian Platonist. As expected in a traditional ballad, the purported minstrel, or rather, an only slightly fictionalized Coleridge, is emotionally reserved in narrating the ancient mariner’s tale, but an investigation into the verbal incoherence in the verse text, together with Coleridge’s life experiences, reveals the poet’s hidden affinity for the penitent protagonist. Coleridge writes the gloss in order to make the poem more intelligible, but also betrays a tormented soul not unlike that of the ancient mariner. As a side note, the author of this paper suggests a change of academic convention by using ‘marginalia’ instead of ‘gloss’ in reference to the poem’s gloss passages, hence dating Coleridge’s first record of publishing marginalia in 1817, not in 1819.1
Non-Herlitz junctional epidermolysis bullosa in a Native American newborn
Authors: Ibrahim Ayah A. , Yrun-Duffy Macken , Almario Rochelle D. , Mullins Jordyn R. , Cyrus Scott S. 
Published: December 2024

Abstract
This case report details the presentation, diagnosis, and management of a newborn Native American male with non-Herlitz junctional epidermolysis bullosa (JEB), a rare diagnosis specifically in the Native American population. Genetic analysis revealed a homozygous mutation in the COL17A1 gene. The management involved multidisciplinary care and highlighted the challenges in treatment, including pain management, wound care, and ethical considerations surrounding adoption within Indigenous communities. This case highlights the importance of tailored interventions and the need for further research into the genetic diversity and prevalence of epidermolysis bullosa (EB) among the Native American population.
Modulation of surface phonon polaritons in MoO3 via dynamic doping of SiC substrate
Authors: Garcia-Pomar Juan Luis , Fandan Rajveer , Calle Fernando , Pedrós Jorge 
Published: December 2024

Abstract
Polar biaxial crystals with extreme anisotropy hold promise for the spatial control and the manipulation of polaritons, as they can undergo topological transitions. However, taking advantage of these unique properties for nanophotonic devices requires to find mechanisms to modulate dynamically the material response. Here, we present a study on the propagation of surface phonon polaritons (SPhPs) in a photonic architecture based on a thin layer of α-MoO3 deposited on a semiconducting 4H-SiC substrate, whose carrier density can be tuned through photoinduction. By employing this system, we establish a comprehensive polaritonic platform where the propagation of the hybridized SPhPs can be manipulated dynamically due to their coupling with the electron plasma. Specifically, we demonstrate that increasing the doping of the 4H-SiC substrate allows for modulating the on/off switch behavior of SPhP propagation or its controlled canalization. Furthermore, this modulation leads to a notable increase in the Purcell factor, primarily attributed to the doping-induced flat dispersion curve creating ultra-slow light. These findings have significant implications for the development of nanophotonic and quantum technologies, as they enable the utilization of polaritonic materials exclusively.
The role and potential of Health Development Offices (HDOs) in maintaining the health of older people in Hungary
Authors: Domján P. , Angyal VZs. , Vingender I. 
Published: December 2024

AbstractPurposeWe investigated health development offices (HDOs) in Hungary as key providers of preventive healthcare services (nutrition, exercise, and mental hygiene programmes) for the general population, with a particular emphasis on health maintenance among people aged 60 and over.Materials and MethodsOur research was informed by the fact that there are currently 113 HDOs operating in Hungary. We carried out a short online survey, for which the sample size (n = 44) was big enough to apply descriptive statistical methods and make statistically significant estimates for different age groups, using a significance level of α = 5% for the target group.ResultsOur research yielded a remarkable finding: around one in two of the clients using the services of the HDOs were over the age of 60. As many as 89% (39 out of 44) of the HDOs participating in the survey provided specific health promotion programmes for individuals over 60 years of age.ConclusionsOur research showed that HDOs are key players in the field of primary prevention among older people, suggesting that they are an important aspect of gerontological care.
Empowering Natural Medicine: Combining Brotowali Extract (T.Crispa) with Lampung Natural Zeolite to Improve Diabetic Wound Healing
Authors: Mulyati Lia , Wulandari Afni , Devi Fitria Kusuma , Rahayuningrat Nurunnisa 
Published: December 2024

Background: Diabetic ulcers are a serious complication that often occurs in people with diabetes mellitus. The complication leads to amputation and causes disability in about 30% of patients.Objective: The study aims to test the effectiveness of an ointment formulation containing brotowali extract with a combination of Lampung natural zeolite (ZAL) in the healing process of diabetic ulcers.Methods: The research method used is quasi-experimental with a control group. The sample of this study used mice, with a total of 6 in each group. Before the intervention, blood sugar levels in the samples were increased by injecting streptozotocin. The study was conducted for 14 days. The Mann-Whitney test was used to analyze the data obtained.Results: The results showed a significant difference in the percentage of wound closure between the control group and the intervention group with p=0.002.Conclusion: Based on these findings, it can be concluded that an ointment formulation containing brotowali extract with a combination of ZAL effectively accelerates the wound healing process in diabetic mice. Brotowali extract ointment with a combination of Lampung natural zeolites can be used as an alternative in wound care for patients with diabetes mellitus based on herbs and local wisdom so that it will be more easily accepted in the community.
Intraoperative Bone Cement Implantation Syndrome in a Pediatric Patient
Authors: Tansey Patrick J. , Wainwright Jared D. , Johnson Blake A. , Montgomery Nicole I. 
Published: December 2024

Case:
A 10-year-old girl with a history of distal femur osteosarcoma underwent resection and limb reconstruction with a cemented custom expandable endoprosthesis. Immediately following stemmed implant insertion, the patient experienced severe cardiopulmonary collapse. Following emergent fluid and oxygen resuscitation by anesthesia, her transient cardiopulmonary instability resolved.

Conclusion:
This is the first report describing acute bone cement implantation syndrome in a pediatric patient. This case highlights the importance of vigilance and interdisciplinary communication with anesthesia when inserting cemented implants in pediatric patients.
A fluorescent aptasensor based on gold nanoparticles for sensitive detection of ofloxacin
Authors: Kong Wei-Chuang , Wu Miao-Miao , Li Chen-Chen , Wang Jiang-Nan , Meng Ya-Li , Jia Xiao-Juan , Xin Zhen-Hui , Kang Yan-Fei 
Published: December 2024

Abstract

Ofloxacin (OFL), as third generation fluoroquinolone antibiotics, is commonly used to treat bacterial infections in humans and animals. However, excessive use of OFL has led to significant environmental contamination, raising concerns about food safety and public health. The current detection methods for OFL residues are often limited by excessive operational complexity, high resource consumption, and constrained application scope, highlighting an urgent need for more efficient and accessible alternatives. In this work, we developed a simple and fast fluorescence aptasensor for detecting OFL based on FRET (Förster Resonance Energy Transfer) between the FAM fluorescent group and gold nanoparticles (AuNPs). The nucleic acid aptamer labeled with FAM (FAM-Apt) binds with the AuNPs to quench FAM fluorescence due to FRET. Upon addition of OFL, OFL preferentially binds with aptamers, leading to fluorescence intensity of FAM-Apt increase. Therefore, this strategy provided the possibility for OFL detection. The results showed that this sensor can selectively detect OFL with a linear range of 0-1500 nM. The limit of detection was detected to be 4.84 nM under optimized conditions. The sensor can be used for detecting OFL in serum, urine, tap-water, river water, pork, chicken and milk with spiked recoveries ranged from 98.00–102.56% and relative standard deviations ranging from 0.41–6.99%. These results demonstrate that this aptasensor offers an accurate, widely applicable potential for OFL monitoring, addressing critical needs in public health and environmental safety by providing an effective method for OFL residue detection in environmental and food samples.
Preparing physiotherapists for the future: the development and evaluation of an innovative curriculum
Authors: Stolwijk Niki , Bergen Anne van , Jetten Evy , Maas Marjo 
Published: December 2024

Abstract

Background
Educational innovation in health professional education is needed to keep up with rapidly changing healthcare systems and societal needs. This study evaluates the implementation of PACE, an innovative curriculum designed by the physiotherapy department of the HAN University of Applied Sciences in The Netherlands. The PACE concept features an integrated approach to learning and assessment based on pre-set learning outcomes, personalized learning goals, flexible learning routes, and programmatic assessment. PACE distinguishes itself from traditional education because of the flexible learning routes, vertical organization in learning communities, absence of pre-defined learning activities and class schedules, and a culture of continuous learning and development. PACE is based on three guiding principles: 1) flexible and varied, 2) self-directed and collaborative, 3) future-oriented. PACE was implemented in 2021 for first-year students. This study evaluates the implementation to inform future curriculum development.
Methods
A sequential explanatory mixed methods design was used to evaluate the implementation of PACE using a questionnaire, focus groups, in-depth interviews, and a national progress test allowing for benchmarking results. Participants were undergraduate physiotherapy students of cohort 2021–2022, the first group who experienced PACE and teachers involved with this cohort. Questionnaire data were analyzed using descriptive statistics. To compare mean total scores of the national progress test between four different universities a one-way ANOVA was conducted including a post-hoc analysis. Reflexive thematic analysis guidelines were applied to analyze the interview data.
Results
In total 82 first year students (44,6%) of cohort 2021–2022 and 36 teachers (60%) completed the questionnaire. Results show that the guiding principles were implemented as intended. Results of the national progress test on knowledge and clinical reasoning showed that students of the HAN University performed well compared to other universities. Thematic analysis of interviews and focus groups resulted in three themes and nine subthemes: 1) navigating a personalized curriculum, 2) caring and sharing, and 3) shaping professional identity. PACE contributed positively to students' intrinsic motivation, learning joy, identity development, and life-long learning skills. Areas for improvement were self-directed learning support, and teaching strategies to prompt deep learning.
Conclusion
The evaluation showed that the guiding principles of PACE were implemented as intended and that the innovation positively contributed to student learning,