bluuebunny/crossref_metadata_2025_split huggingface dataset:
Venice
Authors: Zhao Boyan , Hou Rui , Dong Jianbo , Huang Michael , Mckee Sally A. , Zhang Qianlong , Liu Yueji , Li Ye , Zhang Lixin , Meng Dan 
Published: March 2019

Consolidated server racks are quickly becoming the standard infrastructure for engineering, business, medicine, and science. Such servers are still designed much in the way when they were organized as individual, distributed systems. Given that many fields rely on big-data analytics substantially, its cost-effectiveness and performance should be improved, which can be achieved by flexibly allowing resources to be shared across nodes. Here we describe Venice, a family of data-center server architectures that includes a strong communication substrate as a first-class resource. Venice supports a diverse set of resource-joining mechanisms that enables applications to leverage non-local resources efficiently.
We have constructed a hardware prototype to better understand the implications of design decisions about system support for resource sharing. We use it to measure the performance of at-scale applications and to explore performance, power, and resource-sharing transparency tradeoffs (i.e., how many programming changes are needed). We analyze these tradeoffs for sharing memory, accelerators, and NICs. We find that reducing/hiding latency is particularly important, the chosen communication channels should match the sharing access patterns of the applications, and of which we can improve performance by exploiting inter-channel collaboration.
Hepatic CYP1A2 activity in liver tumors and the implications for preoperative volume-function analysis
Authors: Wuensch Tilo , Heucke Niklas , Wizenty Jonas , Quint Janina , Sinn Bruno , Arsenic Ruza , Jara Maximilian , Kaffarnik Magnus , Pratschke Johann , Stockmann Martin 
Published: March 2019

Dynamic liver function assessment by the [13C]methacetin maximal liver function capacity (LiMAx) test reflects the overall hepatic cytochrome P-450 (CYP) 1A2 activity. One proven strategy for preoperative risk assessment in liver surgery includes the combined assessment of the dynamic liver function by the LiMAx test, the volumetric analysis of the liver, and calculation of future liver remnant function. This so-called volume-function analysis assumes that the remaining CYP1A2 activity in any tumor lesion is zero. The here presented study aims to assess the remaining CYP1A2 activities in different hepatic tumor lesions and its consequences for the preoperative volume-function analysis in patients undergoing liver surgery. The CYP1A2 activity analysis of neoplastic lesions and adjacent nontumor liver tissue from resected tumor specimens revealed a significantly higher CYP1A2 activity (median, interquartile range) in nontumor tissues (35.5, 15.9–54.4 µU/mg) compared with hepatocellular adenomas (7.35, 1.2–32.5 µU/mg), hepatocellular carcinomas (0.18, 0.0–2.0 µU/mg), or colorectal liver metastasis (0.17, 0.0–2.1 µU/mg). In nontumor liver tissue, a gradual decline in CYP1A2 activity with exacerbating fibrosis was observed. The CYP1A2 activity differences were also reflected in CYP1A2 protein signals in the assessed hepatic tissues. Volume-function analysis showed a minimal deviation compared with the current standard calculation for hepatocellular carcinomas or colorectal liver metastasis (<1% difference), whereas a difference of 11.9% was observed for hepatocellular adenomas. These findings are important for a refined preoperative volume-function analysis and improved surgical risk assessment in hepatocellular adenoma cases with low LiMAx values. NEW & NOTEWORTHY The cytochrome P-450 (CYP) 1A2-dependent maximal liver function capacity test reflects the overall functional capacity of the liver. To which extent hepatocellular tumors harbor CYP1A2 activity and thus contribute to the maximal liver function capacity test outcome is unknown. We here show that hepatocellular adenomas but not hepatocellular carcinomas or colorectal liver metastasis contain significant residual CYP1A2 activity. These findings are important for an improved preoperative volume-function analysis and an accurate surgical risk assessment in hepatocellular adenoma cases.
Prolonged low-frequency force depression is underestimated when assessed with doublets compared with tetani in the dorsiflexors
Authors: Ruggiero Luca , Bruce Christina D. , Cotton Paul D. , Dix Gabriel U. , McNeil Chris J. 
Published: March 2019

Prolonged low-frequency force depression (PLFFD) after damaging eccentric exercise may last for several days. Historically, PLFFD has been calculated from the tetanic force responses to trains of supramaximal stimuli. More recently, for methodological reasons, stimulation has been reduced to two pulses. However, it is unknown whether doublet responses provide a valid measure of PLFFD in the days after eccentric exercise. In 12 participants, doublets and tetani were elicited at 10 and 100 Hz before and after (2, 3, 5 min, 48 and 96 h) 200 eccentric maximal voluntary contractions of the dorsiflexors. Doublet and tetanic torque responses at 10 Hz were similarly depressed throughout recovery ( P > 0.05; e.g., 2 min: 58.9 ± 12.8% vs. 57.1 ± 14.5% baseline; 96 h: 85.6 ± 11.04% vs. 85.1 ± 10.8% baseline). At 100 Hz, doublet torque was impaired more than tetanic torque at all time points ( P < 0.05; e.g., 2 min: 70.5 ± 14.2% vs. 88.1 ± 11.7% baseline; 96 h: 83.0 ± 14.2% vs. 98.7 ± 9.5% baseline). As a result, the postfatigue reduction of the 10 Hz-to-100 Hz ratio (PLFFD) was markedly greater for tetani than for doublets ( P < 0.05; e.g., 2 min: 64.3 ± 15.1% vs. 83.0 ± 5.8% baseline). In addition, the doublet ratio recovered by 48 h (99.2 ± 5.0% baseline), whereas the tetanic ratio was still impaired at 96 h (88.2 ± 9.7% baseline). Our results indicate that doublets are not a valid measure of PLFFD in the minutes and days after eccentric exercise. If study design favors the use of paired stimuli, it should be acknowledged that the true magnitude and duration of PLFFD are likely underestimated.NEW & NOTEWORTHY Prolonged low-frequency force depression (PLFFD) will result from damaging exercise and may last for several days. After 200 eccentric maximal dorsiflexor contractions, we compared the gold-standard measure of PLFFD (calculated using trains of supramaximal stimulation) to the value obtained from an alternative technique that is becoming increasingly common (paired supramaximal stimuli). Doublets underestimated the magnitude and duration of PLFFD compared with tetani, so caution must be used when reporting PLFFD derived from paired stimuli.
δ-Catenin Promotes Bevacizumab-Induced Glioma Invasion
Authors: Shimizu Toshihiko , Ishida Joji , Kurozumi Kazuhiko , Ichikawa Tomotsugu , Otani Yoshihiro , Oka Tetsuo , Tomita Yusuke , Hattori Yasuhiko , Uneda Atsuhito , Matsumoto Yuji , Date Isao 
Published: March 2019

Abstract
The combination of bevacizumab with temozolomide and radiotherapy was shown to prolong progression-free survival in newly diagnosed patients with glioblastoma, and this emphasizes the potential of bevacizumab as a glioma treatment. However, although bevacizumab effectively inhibits angiogenesis, it has also been reported to induce invasive proliferation. This study examined gene expression in glioma cells to investigate the mechanisms of bevacizumab-induced invasion. We made a human glioma U87ΔEGFR cell xenograft model by stereotactically injecting these cells into the brain of animals. We administered bevacizumab intraperitoneally three times per week. At 18 days after tumor implantation, the brains were removed for histopathology and mRNA was extracted. In vivo, bevacizumab treatment increased glioma cell invasion. qRT-PCR array analysis revealed upregulation of δ-catenin (CTNND2) and several other factors. In vitro, bevacizumab treatment upregulated δ-catenin expression. A low concentration of bevacizumab was not cytotoxic, but tumor cell motility was increased in scratch wound assays and two-chamber assays. Overexpression of δ-catenin increased the tumor invasion in vitro and in vivo. However, δ-catenin knockdown decreased glioma cell invasiveness. The depth of tumor invasion in the U87ΔEGFR cells expressing δ-catenin was significantly increased compared with empty vector-transfected cells. The increase in invasive capacity induced by bevacizumab therapy was associated with upregulation of δ-catenin expression in invasive tumor cells. This finding suggests that δ-catenin is related to tumor invasion and migration.
Inhibition of the Replication Stress Response Is a Synthetic Vulnerability in SCLC That Acts Synergistically in Combination with Cisplatin
Authors: Nagel Remco , Avelar Ana Teresa , Aben Nanne , Proost Natalie , van de Ven Marieke , van der Vliet Jan , Cozijnsen Miranda , de Vries Hilda , Wessels Lodewyk F. A. , Berns Anton 
Published: March 2019

Abstract
Small cell lung cancer (SCLC) is generally regarded as very difficult to treat, mostly due to the development of metastases early in the disease and a quick relapse with resistant disease. SCLC patients initially show a good response to treatment with the DNA damaging agents cisplatin and etoposide. This is, however, quickly followed by the development of resistant disease, which urges the development of novel therapies for this type of cancer. In this study, we set out to compile a comprehensive overview of the vulnerabilities of SCLC. A functional genome-wide screen where all individual genes were knocked out was performed to identify novel vulnerabilities of SCLC. By analysis of the knockouts that were lethal to these cancer cells, we identified several processes to be synthetic vulnerabilities in SCLC. We were able to validate the vulnerability to inhibition of the replication stress response machinery by use of Chk1 and ATR inhibitors. Strikingly, SCLC cells were more sensitive to these inhibitors than nontransformed cells. In addition, these inhibitors work synergistically with either etoposide and cisplatin, where the interaction is largest with the latter. ATR inhibition by VE-822 treatment in combination with cisplatin also outperforms the combination of cisplatin with etoposide in vivo. Altogether, our study uncovered a critical dependence of SCLC on the replication stress response and urges the validation of ATR inhibitors in combination with cisplatin in a clinical setting.
Impact of Organizational-level Factors on Cancer Screening Activities in Fire Departments: A Cross-sectional Study from the Sylvester Firefighter Cancer Initiative
Authors: Caban-Martinez Alberto J. , Schaefer Solle Natasha , Santiago Katerina M. , Lee David J. , Koru-Sengul Tulay , Bator Christopher G. , Babinec Frank A. , Halas Julius , Kobetz Erin N. 
Published: March 2019

Abstract
Despite known individual-level facilitators of cancer screening, the impact of work-related organizational-level characteristics on cancer screening is unknown particularly in the firefighter workforce who is experiencing a disproportionate burden of cancer. We examine the association between fire service organizational-level factors and implementation of cancer screening activities within Florida fire departments. We used a cross-sectional observational study design to survey fire department leaders attending the Florida Fire Chiefs' Association Health and Safety conference about cancer screening activities implemented by their fire departments. Measures assessing organizational-level characteristics include: fire department workforce size, total health and safety officers, fire department geographic location, employment type, leadership support and capacity. Among the 126 fire departments participating (response rate = 47.7%), approximately 44% reported some type of cancer screening activity in the 12 months prior to survey administration. The proportion of fire departments with two or more health and safety officers was significantly greater among those with cancer screening activities as compared with departments without cancer screening activities (46.3% vs. 24.2%; P = 0.016). There were no statistical differences noted for cancer screening activities among all other organizational-level characteristics including workforce size, fire department geographic location, employment type, leadership support, and individual capacity measures. Most organizational-level characteristics of a fire department evaluated in this study were not associated with cancer screening activities; however, having two or more dedicated health and safety officers supports the delivery of cancer screening activities. These officers may be a key to improving availability of cancer screening activities at work.
Electrophysiological and Anatomical Correlates of Sites With Postpacing Intervals Shorter Than Tachycardia Cycle Length in Atypical Atrial Flutter
Authors: Johner Nicolas , Shah Dipen C. , Jousset Florian , Dall’Aglio Pietro Bernardo , Namdar Mehdi 
Published: March 2019

Background
Although entrainment mapping is an established approach to atypical atrial flutter ablation, postpacing intervals shorter than tachycardia cycle length (difference between postpacing interval and tachycardia cycle length [dPPI] <0 ms) remain of unknown significance. We sought to compare anatomic and electrophysiological properties of sites with dPPI <0, dPPI=0–30, and dPPI >30 ms.

Methods
We studied 24 noncavotricuspid isthmus–dependent macroreentrant atypical atrial flutter in 19 consecutive patients. Ultra high-density electroanatomic activation maps were acquired with a 64-electrode basket catheter. Entrainment mapping was performed at multiple candidate sites. Ablation was performed at the narrowest accessible slow-conducting critical isthmuses.

Results

Of 102 entrainment mapping sites, dPPI <30 was observed at 72 sites on complete maps of 24 atypical atrial flutter. Compared with dPPI=0–30 sites (N=45), dPPI<0 sites (N=27) were more commonly located within isthmuses <15 mm wide (67% versus 6.7%,
P
<0.00001; odds ratio, 28.0; 95% CI, 6.8–115.7), more frequently located within 5 mm of the leading wavefront (93% versus 64%,
P
=0.008), exhibited slower local conduction velocity (0.49±0.43 versus 0.93±0.57 m/s,
P
=0.0005), lower voltages (0.48±0.79 versus 0.92±0.97 mV,
P
=0.04), and more frequently fractionated electrograms (67% versus 24%,
P
=0.0004). High rates of arrhythmia termination or cycle length increase >15 ms by ablation were observed in both dPPI groups (94% versus 86%,
P
=0.53). Compared with all dPPI <30, dPPI >30 sites (N=30) were less commonly observed within isthmuses (3.3%,
P
<0.001) or within 5 mm of the leading wavefront (30%,
P
<0.0001); conduction velocity (1.0±0.7 m/s,
P
=0.002) and voltage (1.1±1.4 mV,
P
=0.049) were higher compared with dPPI<0 but similar to dPPI=0–30 sites.

Conclusions
In atypical atrial flutter, sites with dPPI <0 are markers of limited width critical isthmuses with slower conduction velocity, whereas sites with dPPI=0–30 ms are often not in close proximity to the reentry circuit. Virtual electrode simultaneous down and upstream (antidromic) capture of a confined isthmus of slow conduction can explain a dPPI <0. Identifying these sites may improve selective and efficient ablation strategies compared with the standard 30-ms threshold.
Coronary Artery Calcification and Mortality Risk in Patients With Severe Mental Illness
Authors: Kugathasan Pirathiv , Johansen Martin Berg , Jensen Mikkel Bak , Aagaard Jørgen , Nielsen René Ernst , Jensen Svend Eggert 
Published: March 2019

Background
Cardiovascular mortality is the leading contributor to the shortened life expectancy in patients with severe mental illness (SMI), but efforts to predict cardiovascular outcomes in these patients have been lacking. In this study, we aimed to determine the severity of coronary artery calcification (CAC), and its effect on mortality rates in patients with SMI, compared with the general population.

Methods

All individuals with a registered cardiac computed tomography for calcium scoring in the Western Denmark Heart Registry, from January 1, 2008 to December 31, 2016, were included. We identified patients diagnosed with SMI (
International Classification of Diseases, Tenth Revision
: F20, F30, F31), whereas the remaining individuals were used as a comparison group.

Results
Among 48 757 individuals, including 564 patients with SMI (1.2%), we found no difference in CAC score between patients with SMI and the comparison group. SMI patients with CAC >100 had an increased mortality rate (hazard ratio, 3.16; 95% CI, 1.41–7.06), as well as SMI patients with CAC <100 (hazard ratio, 3.95; 95% CI, 2.36–6.62), compared with the comparison group with CAC <100 as reference, adjusted for age, sex, and calendar period.

Conclusions
Patients with SMI have increased cardiovascular risks, but show no difference in CAC score, compared with the comparison group. Mortality rates were increased in patients with SMI, independent of CAC severity; however, the relatively large number of noncardiovascular causes of death in this sample might indicate other contributing factors to death than coronary artery disease in this sample of SMI patients.
Atrial Fibrillation and Brain Magnetic Resonance Imaging Abnormalities
Authors: Berman Jeremy P. , Norby Faye L. , Mosley Thomas , Soliman Elsayed Z. , Gottesman Rebecca F. , Lutsey Pamela L. , Alonso Alvaro , Chen Lin Y. 
Published: March 2019

Background and Purpose—
Atrial fibrillation (AF) is associated with dementia independent of clinical stroke. The mechanisms underlying this association remain unclear. In a community-based cohort, the ARIC study (Atherosclerosis Risk in Communities), we evaluated (1) the longitudinal association of incident AF and (2) the cross-sectional association of prevalent AF with brain magnetic resonance imaging (MRI) abnormalities.

Methods—
The longitudinal analysis included 963 participants (mean age, 73±4.4 years; 62% women; 51% black) without prevalent stroke or AF who underwent a brain MRI in 1993 to 1995 and a second MRI in 2004 to 2006 (mean, 10.6±0.8 years). Outcomes included subclinical cerebral infarctions, sulcal size, ventricular size, and, for the cross-sectional analysis, white matter hyperintensity volume and total brain volume.

Results—
In the longitudinal analysis, 29 (3.0%) participants developed AF after the first brain MRI. Those who developed AF had higher odds of increase in subclinical cerebral infarctions (odds ratio [OR], 3.08; 95% CI, 1.39–6.83), worsening sulcal grade (OR, 3.56; 95% CI, 1.04–12.2), and worsening ventricular grade (OR, 9.34; 95% CI, 1.24–70.2). In cross-sectional analysis, of 969 participants, 35 (3.6%) had prevalent AF at the time of the 2004 to 2006 MRI scan. Those with AF had greater odds of higher sulcal (OR, 3.9; 95% CI, 1.7–9.1) and ventricular grade (OR, 2.4; 95% CI, 1.0–5.7) after multivariable adjustment and no difference in white matter hyperintensity or total brain volume.

Conclusions—
AF is independently associated with increase in subclinical cerebral infarction and worsening sulcal and ventricular grade—morphological changes associated with aging and dementia. More research is needed to define the mechanisms underlying AF-related neurodegeneration.
International Governance of Oil Spills from Upstream Petroleum Activities in the Arctic: Response over Prevention?
Authors: Shapovalova-Krout Daria 
Published: March 2019

Abstract
Discovery of petroleum resources in Arctic waters and the rapid loss of sea ice raise concerns over environmental risks of oil development in Arctic waters. One of the biggest threats to the marine environment from offshore oil production is a large-scale oil spill, akin to Deepwater Horizon. The challenging operating conditions, lack of infrastructure and effective clean-up techniques in the Arctic conditions exacerbate the need to ensure robust regulation of petroleum activities in the region. Whereas national laws vary extensively across the Arctic States, international law does not offer a uniform approach to prevention of and response to oil spills. This paper examines the scope and application of the relevant treaties and argues that a regulatory gap exists in the prevention of oil spills and addressing the challenges of response in Arctic conditions. It further suggests that there is an increasing role for soft-law regional cooperation in addressing these gaps.
Toward Convective-Scale Prediction within the Next Generation Global Prediction System
Authors: Zhou Linjiong , Lin Shian-Jiann , Chen Jan-Huey , Harris Lucas M. , Chen Xi , Rees Shannon L. 
Published: March 2019

AbstractThe Geophysical Fluid Dynamics Laboratory (GFDL) has developed a new variable-resolution global model with the ability to represent convective-scale features that serves as a prototype of the Next Generation Global Prediction System (NGGPS). The goal of this prediction system is to maintain the skill in large-scale features while simultaneously improving the prediction skill of convectively driven mesoscale phenomena. This paper demonstrates the new capability of this model in convective-scale prediction relative to the current operational Global Forecast System (GFS). This model uses the stretched-grid functionality of the Finite-Volume Cubed-Sphere Dynamical Core (FV3) to refine the global 13-km uniform-resolution model down to 4-km convection-permitting resolution over the contiguous United States (CONUS), and implements the GFDL single-moment 6-category cloud microphysics to improve the representation of moist processes. Statistics gathered from two years of simulations by the GFS and select configurations of the FV3-based model are carefully examined. The variable-resolution FV3-based model is shown to possess global forecast skill comparable with that of the operational GFS while quantitatively improving skill and better representing the diurnal cycle within the high-resolution area compared to the uniform mesh simulations. Forecasts of the occurrence of extreme precipitation rates over the southern Great Plains are also shown to improve with the variable-resolution model. Case studies are provided of a squall line and a hurricane to demonstrate the effectiveness of the variable-resolution model to simulate convective-scale phenomena.
Evolution of Ocean Heat Content Related to ENSO
Authors: Cheng Lijing , Trenberth Kevin E. , Fasullo John T. , Mayer Michael , Balmaseda Magdalena , Zhu Jiang 
Published: March 2019

Abstract
As the strongest interannual perturbation to the climate system, El Niño–Southern Oscillation (ENSO) dominates the year-to-year variability of the ocean energy budget. Here we combine ocean observations, reanalyses, and surface flux data with Earth system model simulations to obtain estimates of the different terms affecting the redistribution of energy in the Earth system during ENSO events, including exchanges between ocean and atmosphere and among different ocean basins, and lateral and vertical rearrangements. This comprehensive inventory allows better understanding of the regional and global evolution of ocean heat related to ENSO and provides observational metrics to benchmark performance of climate models. Results confirm that there is a strong negative ocean heat content tendency (OHCT) in the tropical Pacific Ocean during El Niño, mainly through enhanced air–sea heat fluxes Q into the atmosphere driven by high sea surface temperatures. In addition to this diabatic component, there is an adiabatic redistribution of heat both laterally and vertically (0–100 and 100–300 m) in the tropical Pacific and Indian oceans that dominates the local OHCT. Heat is also transported and discharged from 20°S–5°N into off-equatorial regions within 5°–20°N during and after El Niño. OHCT and Q changes outside the tropical Pacific Ocean indicate the ENSO-driven atmospheric teleconnections and changes of ocean heat transport (i.e., Indonesian Throughflow). The tropical Atlantic and Indian Oceans warm during El Niño, partly offsetting the tropical Pacific cooling for the tropical oceans as a whole. While there are distinct regional OHCT changes, many compensate each other, resulting in a weak but robust net global ocean cooling during and after El Niño.