bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiosensitizing effects of miR‐18a‐5p on lung cancer stem‐like cells via downregulating both ATM and HIF‐1α
Authors: Chen Xu , Wu Lei , Li Dezhi , Xu Yanmei , Zhang Luping , Niu Kai , Kong Rui , Gu Jiaoyang , Xu Zihan , Chen Zhengtang , Sun Jianguo 
Published: June 2018

AbstractLung cancer is one of the main causes of cancer mortality globally. Most patients received radiotherapy during the course of disease. However, radioresistance generally occurs in the majority of these patients, leading to poor curative effect, and the underlying mechanism remains unclear. In the present study, miR‐18a‐5p expression was downregulated in irradiated lung cancer cells. Overexpression of miR‐18a‐5p increased the radiosensitivity of lung cancer cells and inhibited the growth of A549 xenografts after radiation exposure. Dual luciferase report system and miR‐18a‐5p overexpression identified ataxia telangiectasia mutated (ATM) and hypoxia inducible factor 1 alpha (HIF‐1α) as the targets of miR‐18a‐5p. The mRNA and protein expressions of ATM and HIF‐1α were dramatically downregulated by miR‐18a‐5p in vitro and in vivo. Clinically, plasma miR‐18a‐5p expression was significantly higher in radiosensitive than in radioresistant group (P < .001). The cutoff value of miR‐18a‐5p >2.28 was obtained from receiver operating characteristic (ROC) curve. The objective response rate (ORR) was significantly higher in miR‐18a‐5p‐high group than in miR‐18a‐5p‐low group (P < .001). A tendency demonstrated that the median local progression‐free survival (PFS) from radiotherapy was longer in miR‐18a‐5p‐high than in miR‐18a‐5p‐low group (P = .082). The median overall survival (OS) from radiotherapy was numerically longer in miR‐18a‐5p‐high than in miR‐18a‐5p‐low group (P = .281). The sensitivity and specificity of plasma miR‐18a‐5p to predict radiosensitivity was 87% and 95%, respectively. Collectively, these results indicate that miR‐18a‐5p increases the radiosensitivity in lung cancer cells and CD133+ stem‐like cells via downregulating ATM and HIF‐1α expressions. Plasma miR‐18a‐5p would be an available indicator of radiosensitivity in lung cancer patients.
PIK3CA c.3140A>G mutation in a patient with suspected Proteus Syndrome: a case report
Authors: Valentini Virginia , Zelli Veronica , Rizzolo Piera , Silvestri Valentina , Alimandi Maurizio , D'Aloia Maria Michela , Giustini Sandra , Calvieri Stefano , Richetta Antonio Giovanni , Monteleone Giovanni , Ottini Laura 
Published: June 2018

Key Clinical MessageWe present a patient with suspected Proteus Syndrome, an overgrowth disorder associated with AKT1c.49G>A mutation. NGS analysis detected PIK3CAc.3140A>G mutation in the patient's affected tissue allowing for PROS (PIK3CA‐related overgrowth spectrum) diagnosis. The overlapping clinical features in overgrowth disorders highlight the importance of molecular testing for a correct diagnosis.
Fitz‐Hugh–Curtis syndrome: a diagnostic challenge
Authors: Jia Wei , Fadhlillah Fiqry 
Published: June 2018

Key Clinical MessageDiagnosis of Fitz‐Hugh–Curtis is challenging due to its rarity and its similar presentation to common intra‐abdominal conditions, such as cholecystitis or appendicitis. In our case, the adherent cecal and omental mass felt on examination were thought to be an appendiceal mass secondary to perforation, hence the patient underwent a diagnostic laparoscopy.
Experimental and Theoretical Analysis of Foaming in Diethanolamine‐Sour Gas Contactors
Authors: Shahraki Bahram Hashemi , Fatemi Mahmoud 
Published: June 2018

AbstractFoaming and foam stability of impure aqueous diethanolamine (DEA) solution were evaluated. The impurities used in the experiments were gas oil, normal hexane, iron oxides, and bicine. Bikerman's method was selected to study the foaming phenomenon. A predetermined quantity of impurity was added to aqueous DEA solution and pure CO2 was allowed to flow into the solution with a constant flow rate which resulted in the formation of a height of foam bubbles on the gas‐liquid interface. At the equilibrium height of the foam, the foaming index of the impure solutions was calculated for different impurities and compared. The shrinking speed of the foam and the foam half‐life were recorded as foam stability parameters. The presence of liquid hydrocarbons and iron oxide in DEA solution intensified solution foaming more than other impurities. To predict the parameters influencing foam stability, a mathematical model was developed.
Debris flow protection with flexible ring net barriers – 10 years of experience
Authors: WENDELER Corinna , BUDIMIR Vjekoslav , DENK Mathias 
Published: June 2018

AbstractFlexible ring net barriers against debris flow have been installed worldwide during the last 10 years mainly for the purpose of debris retention and a few as erosion control. An increasing number of client projects (40 barriers within Switzerland, more than 100 worldwide by 2017) shows the interest in this solution. This article highlights different special applications such as one single barrier providing a very large retention capacity, an example of several barriers in line and filled up barriers for erosion control. Advantages and challenges for the use of flexible ring net barriers are discussed on a technical and economic level and needs for maintenance and replacement works are addressed.
Synthesis of Fluidized CO2 Sorbents Based on Diamine Coordinated to Metal–Organic Frameworks by Direct Conversion of Metal Oxides Supported on Mesoporous Silica
Authors: Luz Ignacio , Soukri Mustapha , Lail Marty 
Published: June 2018

AbstractA general and efficient method for shaping MOFs into fluidized forms has been developed by direct conversion of metal oxides supported on fluidized mesoporous silica. The resulting fluidized MOF hybrid materials containing diamines coordinated at the open metal sites have been studied as CO2 solid sorbents from post‐combustion flue gas showing similar performance than their bulk counterparts. These new fluidized MOF hybrid materials can be used for other applications involving fluidized bed reactor configurations, in which MOFs have never been considered.
Synthesis and Characterization of Nanotubes from Misfit (LnS)1+yTaS2 (Ln=Pr, Sm, Gd, Yb) Compounds
Authors: Serra Marco , Stolovas Dalit , Houben Lothar , Popovitz‐Biro Ronit , Pinkas Iddo , Kampmann Felix , Maultzsch Janina , Joselevich Ernesto , Tenne Reshef 
Published: June 2018

AbstractThe synthesis and characterization of nanotubes from misfit layered compounds (MLCs) of the type (LnS)1+yTaS2 (denoted here as LnS‐TaS2; Ln=Pr, Sm, Gd, and Yb), not reported before, are described (the bulk compound YbS‐LaS2 was not previously documented). Transmission electron microscopy and selected area electron diffraction showed that the interlayer spacing along the c axis decreased with an increase in the atomic number of the lanthanide atom, which suggested tighter interaction between the LnS layer and TaS2 for the late lanthanides. The Raman spectra of the tubules were studied and compared to those of the bulk MLC compounds. Similar to the bulk MLCs, the Raman spectra could be divided into the low‐frequency modes (110–150 cm−1) of the LnS lattice and the high‐frequency modes (250–400 cm−1) of the TaS2 lattice. The Raman spectra indicated that the vibrational lattice modes of the strained layers in the tubes were stiffer than those in the bulk compounds. Furthermore, the modes of the late lanthanides were higher in energy than those of the earlier lanthanides, which suggested larger charge transfer between the LnS and TaS2 layers for the late lanthanides. Polarized Raman measurements showed the expected binodal intensity profile (antenna effect). The intensity ratio of the Raman signal showed that the E2g mode of TaS2 was more sensitive to the light‐polarization effect than its A1g mode. These nanotubes are expected to reveal interesting low‐temperature quasi‐1D transport behavior.
Detection of erythropoiesis‐stimulating agents in a single dried blood spot
Authors: Reverter‐Branchat Gemma , Ventura Rosa , Ezzel Din Mohammed , Mateus Julián , Pedro Carme , Segura Jordi 
Published: June 2018

AbstractThe use of dried blood spots (DBS) for anti‐doping purposes would facilitate an increase in the number of blood samples because it eliminates the need for specialized personnel and involves minimal invasiveness, reduced costs, stability, and easy transportation and storage. Here, the electrophoretic methodology established by the World Anti‐Doping Agency (WADA) to detect erythropoiesis‐stimulating agents (ESAs) has been adapted to evaluate their applicability to DBS. A qualitative procedure to detect recombinant erythropoietin (rEPO), novel erythropoiesis‐stimulating protein (NESP), and continuous erythropoietin receptor activator (CERA) in a single DBS was optimized and validated. For rEPO and NESP, confirmation was performed in finger‐prick DBS from a pilot study and an administration patients study, respectively. For CERA, detection capabilities were evaluated in DBS prepared with modeled‐blood spiked with known concentrations of the protein. Main validation parameters concerning DBS sampling such as stability, hematocrit influence, and blood type (capillary vs. venous) described minor variations. Onsite drying appeared not to be essential before transport. Intra‐ and inter‐day variation range was 2.9%–23.5%. Linearity was maintained (r ≥ 0.9) and ESAs were robustly recovered (CV ≤ 20.2%). The validated method permitted the detection of treated subjects after 48 hours and 17 days of rEPO and NESP administration, respectively. The reproduction of a CERA pharmacokinetics showed good possibilities for the method with a detection window that could reach 16 days after its actual administration. Thus, results provided here reinforce the suitability of DBS blood sampling for the analysis of ESA misuse in sports drug testing.
Error management theory and the adaptive significance of transgenerational maternal‐stress effects on offspring phenotype
Authors: Sheriff Michael J. , Dantzer Ben , Love Oliver P. , Orrock John L. 
Published: June 2018

AbstractIt is well established that circulating maternal stress hormones (glucocorticoids, GCs) can alter offspring phenotype. There is also a growing body of empirical work, within ecology and evolution, indicating that maternal GCs link the environment experienced by the mother during gestation with changes in offspring phenotype. These changes are considered to be adaptive if the maternal environment matches the offspring's environment and maladaptive if it does not. While these ideas are conceptually sound, we lack a testable framework that can be used to investigate the fitness costs and benefits of altered offspring phenotypes across relevant future environments. We present error management theory as the foundation for a framework that can be used to assess the adaptive potential of maternal stress hormones on offspring phenotype across relevant postnatal scenarios. To encourage rigorous testing of our framework, we provide field‐testable hypotheses regarding the potential adaptive role of maternal stress across a diverse array of taxa and life histories, as well as suggestions regarding how our framework might provide insight into past, present, and future research. This perspective provides an informed lens through which to design and interpret experiments on the effects of maternal stress, provides a framework for predicting and testing variation in maternal stress across and within taxa, and also highlights how rapid environmental change that induces maternal stress may lead to evolutionary traps.
Antibiotic‐induced effects on scaling relationships and on plant element contents in herbs and grasses
Authors: Minden Vanessa , Schnetger Bernhard , Pufal Gesine , Leonhardt Sara D. 
Published: June 2018

AbstractPlant performance is correlated with element concentrations in plant tissue, which may be impacted by adverse chemical soil conditions. Antibiotics of veterinary origin can adversely affect plant performance. They are released to agricultural fields via grazing animals or manure, taken up by plants and may be stored, transformed or sequestered by plant metabolic processes. We studied the potential effects of three antibiotics (penicillin, sulfadiazine, and tetracycline) on plant element contents (macro‐ and microelements). Plant species included two herb species (Brassica napus and Capsella bursa‐pastoris) and two grass species (Triticum aestivum and Apera spica‐venti), representing two crop species and two noncrop species commonly found in field margins, respectively. Antibiotic concentrations were chosen as to reflect in vivo situations, that is, relatively low concentrations similar to those detected in soils. In a greenhouse experiment, plants were raised in soil spiked with antibiotics. After harvest, macro‐ and microelements in plant leaves, stems, and roots were determined (mg/g). Results indicate that antibiotics can affect element contents in plants. Penicillin exerted the greatest effect both on element contents and on scaling relationships of elements between plant organs. Roots responded strongest to antibiotics compared to stems and leaves. We conclude that antibiotics in the soil, even in low concentrations, lead to low‐element homeostasis, altering the scaling relationships between roots and other plant organs, which may affect metabolic processes and ultimately the performance of a plant.
An “Omics” Approach for Lipid Oxidation in Foods: The Case of Free Fatty Acids in Bulk Purified Olive Oil
Authors: Paradiso Vito M. , Pasqualone Antonella , Summo Carmine , Caponio Francesco 
Published: June 2018

Monitoring or preventing oxidation processes in foods, particularly heterogeneous systems or highly oxidizable lipids, has become a primary issue. Traditional approaches often fail in pursuing this aim. At the same time, the prediction in laboratory of the efficacy of antioxidant molecules and technologies often fails when challenging reality. A change in the traditional paradigm used to conceive oxidation processes and their monitoring could be a key. In the present work, an “omics” approach is suggested for the evaluation of oxidation in food lipids and of the role played by minor compounds. This holistic and comprehensive, hypothesis‐generating approach is applied to a typical research case: highly‐purified olive oil added with increasing amounts of purified free fatty acids (FFA). A comprehensive profile (“oxidome”) of oxidation products is outlined during the accelerated oxidation. The pathways considered are FFA and triacyglycerol oxidation, triacyglycerol polymerization, volatile compounds formation as well as their further oxidation. FFA affectes the overall balance of the oxidation pathways and consequently causes a drift in the evolution of the pattern of oxidation products. The balance between accelerating activity of FFA toward triacylglycerol oxidation and their high susceptibility to undergo oxidation turnes out to be dose‐dependent and time‐related, and shiftes the resulting oxidation profile of the oil. The omics approach to oxidation products profiling provides new insight into oxidation processes. “Oxidomics” could be helpful to deepen the insight into unresolved issues of oxidation, going beyond the usual single‐ or few‐marker approach.Practical Applications: This research suggests a new paradigm for approaching food lipid oxidation. Unresolved practical issues regarding food spoilage and shelf‐life, waste reduction, keeping of healthy properties are increasing along the increasing formulation of complex and dispersed systems, use of healthy highly unsaturated fatty acids and bioactive antioxidants, attention paid by consumers and industries to nutritional, sensory, health properties of foods. The new paradigm suggests going beyond the usually adopted single‐ or few‐marker approach and to consider the pattern of oxidation reactions and products as a whole, in order to better describe and predict its changes and the effects of external factors as well as added molecules.“Oxidomics” is a new paradigm for lipid oxidation, with a holistic approach to the system and evaluating a pattern of oxidation products and its changes.
How nostalgia infuses life with meaning: From social connectedness to self‐continuity
Authors: van Tilburg Wijnand A. P. , Sedikides Constantine , Wildschut Tim , Vingerhoets Ad J. J. M. 
Published: June 2018

AbstractNostalgia increases meaning in life (MIL), but how so? In four experiments—using varied operationalizations of nostalgia, diverse populations, and complementary methodologies—we identified a serial process. We hypothesized and found, in Experiment 1, that self‐continuity boosts MIL. We hypothesized and found, in Experiment 2, that nostalgia increases MIL through self‐continuity. Finally, we hypothesized and found, in Experiments 3–4, that nostalgia fosters social connectedness, which plausibly heightens self‐continuity, which in turn strengthens MIL. The findings clarify an intricate pathway through which nostalgia renders life more meaningful.
Probiotic potentials of Lactobacillus plantarum isolated from fermented durian (Tempoyak), a Malaysian traditional condiment
Authors: Ahmad Asmariah , Yap Wei Boon , Kofli Noorhisham Tan , Ghazali Ahmad Rohi 
Published: June 2018

AbstractLactic acid bacterium isolated from fermented durian (tempoyak) was investigated for its potentials as a probiotic strain. Bacterial tolerance toward gastrointestinal environment, adhesion, and cytotoxic activity in human colon adenocarcinoma cell line HT‐29 was evaluated. 16S rRNA sequencing identified the lactic acid bacterium as Lactobacillus plantarum. The bacterium demonstrated good tolerance toward gastrointestinal pH 2.0 and 0.3% bile salts. It showed strong adhesive capacity in human intestinal cell line, HT‐29, with an adhesion index of 159 ± 10. Cytotoxicity of L. plantarum was investigated using both live bacterial cells (BC) and cell‐free supernatant (CFS). Findings showed that both BC and CFS of L. plantarum reduced proliferation of HT‐29 colon adenocarcinoma cells using MTT assay. The results imply potential probiotic properties of L. plantarum isolated from tempoyak.
Effect of ABCC2 and ABCG2 Gene Polymorphisms and CSF‐to‐Serum Albumin Ratio on Ceftriaxone Plasma and Cerebrospinal Fluid Concentrations
Authors: Allegra Sarah , Cardellino Chiara Simona , Fatiguso Giovanna , Cusato Jessica , De Nicolò Amedeo , Avataneo Valeria , Bonora Stefano , D'Avolio Antonio , Di Perri Giovanni , Calcagno Andrea 
Published: June 2018

AbstractWe measured ceftriaxone pharmacokinetics in patients’ plasma and cerebrospinal fluid (CSF) and assessed the influence of biometric, demographic, genetic (ABCB1, ABCC2, ABCB11, ABCG2, and SLCO1A2 polymorphisms) and pathological features. Adult patients with signs and symptoms of central nervous system infections, receiving intravenous ceftriaxone, were enrolled. Ceftriaxone plasma and CSF concentrations were measured by high‐precision liquid chromatographic methods; allelic discrimination was performed by real‐time polymerase chain reaction. Forty‐three patients were included: median ceftriaxone maximal concentration was 15,713 ng/mL in plasma and 3512 ng/mL in CSF with a CSF‐to‐plasma ratio of 0.3. ABCC2 1249 rs2273697 (P = .027) and ABCG2 1194+928 rs13120400 (P = .015) variants were significantly associated with CSF concentrations and CSF‐to‐plasma ratios. At linear regression analysis, CSF‐to‐serum albumin ratio was an independent predictor of ceftriaxone CSF concentrations (P = .001; also in those with intact blood‐brain barrier: P = .031) and CSF‐to‐plasma ratio (P = .001; also in those with blood‐brain barrier impairment: P = .040). We here report the role of transporters’ genetic variants as well as of blood‐brain barrier permeability in predicting ceftriaxone exposure in the central nervous system.
Mood—Creativity Relationship in Groups: The Role of Equality in Idea Contribution in Temporal Mood Effects
Authors: Leung Angela K.‐Y. , Liou Shyhnan , Tsai Ming‐Hong , Koh Brandon 
Published: June 2018

AbstractAs people working in groups might fare better in solving complex problems than those working alone (e.g., Laughlin, Hatch, Silver, & Boh,Journal of Personality and Social Psychology,90, 2006 and 644), organizations have increasingly assigned creative projects to groups. Group members contribute their collective efforts over time until the creative project has come to fruition. Although mood is identified as an important antecedent to creativity, little is known about the temporal pattern of how group mood enhances or inhibits group creativity, as well as the underpinning group process that explains the mood—creativity link in groups. We set out to address these questions by taking a within‐group approach to study the temporal trends of how group mood precedes group creativity and to examine idea contribution equality (ICE) as a mediating group process. We conducted a three‐wave longitudinal study among student workgroups tasked to complete a creativity project over a 1‐month span. Evidence showed that positive mood is positively associated with concurrentICEand negative mood is negatively associated with laggedICE. Furthermore, a mediation model showed that negative mood eventually hampered expert‐rated group creative performance by reducingICEover time. These findings add new knowledge to the temporal mood—creativity relation within the group context.
Smartphone imaging of subcutaneous veins
Authors: Lewis William , Franco Walfre 
Published: June 2018

ObjectiveThe identification of veins by medical personnel is a critical skill that is necessary to draw blood or administer intravenous fluids and medications. Because a normal consumer camera can act as a multispectral imaging apparatus, operating with three broadband detectors, we hypothesized that a standard smartphone camera might be employed for enhanced visualization of veins in human skin.StudyVideo and images of subcutaneous veins were acquired using the rear‐facing iSight camera from an iPhone 6, with a fixed aperture of f/2.2, and Sony Exmor RS back‐illuminated CMOS image sensor with pixel generation of 1.5 microns. A custom program was written for the iOS operating system that performs a scaled matrix subtraction of different spectral channels and displays results as a grayscale image.ResultsA scaled subtraction of green channel pixel values from red channel pixel values enabled greatly improved identification of subcutaneous veins. Wavelengths of light at which the green detector is most sensitive (520–580 nm) correspond to local absorption maxima of both oxyhemoglobin (542 and 576 nm) and deoxyhemoglobin (556 nm); consequently, the algorithm obtained images of light transport weighted toward deeper skin layers.ConclusionWe identified and developed a simple algorithm by which a standard smartphone camera can be employed for enhanced video‐rate visualization of veins in human skin. Lasers Surg. Med. 50:1034–1039, 2018. © 2018 Wiley Periodicals, Inc.