bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementasi Knowledge Management di Perpustakaan dalam Membangun Koleksi Warisan Budaya Batik
Authors: Husna Jazimatul 
Published: March 2019

Tulisan ini dimaksudkan untuk menemukan peran knowledge mananagement dalam membangun koleksi warisan budaya. Beberapa perpustakaan di Indonesia sudah memiliki inisiatif dalam pelestarian warisan budaya. Perpustakaan-perpustakaan yang mulai Membangun koleksi warisan budaya mereka. Perpustakaan terus memasukkan kesadaran warisan di antara masyarakat, dan mereka akan tahu tentang budaya mereka. Berbagai alasan melatar belakangi tulisan ini sebagai dasar pemikiran yang berguna untuk membuat sebuah pusat pengetahuan manajemen tentang khasanah budaya khusunya Batik, Peneletian ini membahas peran knowledge mananagement di perpustakaan. Sangat Penting, upaya-upaya dalam rangka mewujudkan fungsinya sebagai pelestari budaya semakin terasa dengan hadirnya beberapa layanan perpustakaan yang ingin mengusung sebuah informasi yang terkait dengan kekhasan dari ketentuan daerah tertentu. Perpustakaan juga dapat menjadi jembatan dan fasilitator untuk menciptakan, menyimpan, menyatukan, dan membagikan bahan pelestari batik, dan juga menjadi bahan yang kompetitif, efektif dan efisien untuk menciptakan batik.
Development and Validation of a Novel Reversed Phase High Performance Liquid Chromatography with Refractive Index Detector Method for Assay of Polyvinyl Alcohol in an Ophthalmic Solution
Authors: Ergen Harun , Guleli Muge , Sener Cigdem , Caliskan Cem , Semiz Sercan , Ozbek Mahmut 
Published: March 2019

Introduction:Polyvinyl alcohol (PVA), a polymer, is in demand due to its usage in different applications such as pharmaceutical, biomedical and textile, paper, food industries.Methods:A new sensitive reversed phased high-pressure liquid chromatography (RP-HPLC) method with refractive index detector (RID) was developed for determination of PVA in an ophthalmic solution containing dexpanthenol and PVA as active substances and it was validated according to The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guideline.Results:Chromatographic separation was achieved on a Chiral-AGP (150 mm × 4.0 mm, 5 μm) column kept at 30°C with an isocratic flow at a flow rate of 1.0 ml/min. The detector temperature was 30°C, the retention time of PVA was around 1.0 min and the total run time was 5 minutes.Conclusion:The proposed method showed linearity, accuracy, precision, specificity, robustness, solution stability, and system suitability results within the acceptance criteria.
A Secure Reversible Data Hiding and Encryption System for Embedding EPR in Medical Images
Authors: Ayyappan Sonal , Lakshmi C. , Menon Varun 
Published: March 2019

Background:
Recent advances in medical associated technologies have drastically increased
the amount of electronic medical records collected, stored and transferred through the
network. Considering the significance and level of sensitivity of the collected medical data, the
security of the transmitted data has become a very vital and challenging task for researchers. The
protection of these medical images with embedded data is usually guaranteed using encryption or
data hiding techniques. Conventional techniques that employ encryption or data hiding are often
insecure and also time-consuming during transmission through the network.

Materials and Methods:
A method combining encryption and data hiding together can result in
compression of data that reduces the transmission time and increases the security level. Reversible
data hiding in images can reestablish the cover image after extracting the hidden embedded data
exclusive of alterations. Here a new reversible crypto-watermarking system is proposed using
cryptographic algorithms that encrypts and hides an Electronic Patient Record (EPR) into an image
corresponding to that patient using Rhombus Prediction Scheme. It embeds a big amount of
encrypted data into an image with hardly noticeable modification using spatial pixel manipulations
based on prediction errors. The marked image is hashed using SHA-256 algorithm.

Results and Conclusion:
Hashing and cryptography increases the robustness and guarantees authenticity
with integrity. The proposed method results in improved safety with a lower transmission
time than the existing methods.
Morphological Segmentation Analysis and Texture-based Support Vector Machines Classification on Mice Liver Fibrosis Microscopic Images
Authors: Wang Yu , Shi Fuqian , Cao Luying , Dey Nilanjan , Wu Qun , Ashour Amira Salah , Sherratt Robert Simon , Rajinikanth Venkatesan , Wu Lijun 
Published: March 2019

Background:
To reduce the intensity of the work of doctors, pre-classification work
needs to be issued. In this paper, a novel and related liver microscopic image classification
analysis method is proposed.

Objective:
For quantitative analysis, segmentation is carried out to extract the quantitative
information of special organisms in the image for further diagnosis, lesion localization, learning
and treating anatomical abnormalities and computer-guided surgery.
</P><P>
Methods: In the current work, entropy-based features of microscopic fibrosis mice’ liver images
were analyzed using fuzzy c-cluster, k-means and watershed algorithms based on distance
transformations and gradient. A morphological segmentation based on a local threshold was
deployed to determine the fibrosis areas of images.

Results:
The segmented target region using the proposed method achieved high effective
microscopy fibrosis images segmenting of mice liver in terms of the running time, dice ratio and
precision. The image classification experiments were conducted using Gray Level Co-occurrence
Matrix (GLCM). The best classification model derived from the established characteristics was
GLCM which performed the highest accuracy of classification using a developed Support Vector
Machine (SVM). The training model using 11 features was found to be accurate when only trained
by 8 GLCMs.

Conclusion:
The research illustrated that the proposed method is a new feasible research approach
for microscopy mice liver image segmentation and classification using intelligent image analysis
techniques. It is also reported that the average computational time of the proposed approach was
only 2.335 seconds, which outperformed other segmentation algorithms with 0.8125 dice ratio and
0.5253 precision.</P>
Nitrogen Mustards as Alkylating Agents: A Review on Chemistry, Mechanism of Action and Current USFDA Status of Drugs
Authors: More Ghansham S. , Thomas Asha B. , Chitlange Sohan S. , Nanda Rabindra K. , Gajbhiye Rahul L. 
Published: March 2019

Background & Objective: :Nitrogen mustard derivatives form one of the major classes of anti-cancer agents in USFDA approved drugs list. These are polyfunctional alkylating agents which are distinguished by a unique mechanism of adduct formation with DNA involving cross-linking between guanine N-7 of one strand of DNA with the other. The generated cross-linking is irreversible and leads to cell apoptosis. Hence it is of great interest to explore this class of anticancer alkylating agents.Methods::An exhaustive list of reviews, research articles, patents, books, patient information leaflets, and orange book is presented and the contents related to nitrogen mustard anti-cancer agents have been reviewed. Attempts are made to present synthesis schemes in a simplified manner. The mechanism of action of the drugs and their side effects are also systematically elaborated.Results::This review provides a platform for understanding all aspects of such drugs right from synthesis to their mechanism of action and side effects, and lists USFDA approved ANDA players among alkylating anticancer agents in the current market.Conclusion: :Perusing this article, generic scientists will be able to access literature information in this domain easily to gain insight into the nitrogen mustard alkylating agents for further ANDA development. It will help the scientific and research community to continue their pursuit for the design of newer and novel heterocyclic alkylating agents of this class in the coming future.
Safety of Electronic Cigarette Use During Breastfeeding: Qualitative Study Using Online Forum Discussions
Authors: Johnston Emily Jade , Campbell Katarzyna , Coleman Tim , Lewis Sarah , Orton Sophie , Cooper Sue 
Published: March 2019

Background
Electronic cigarettes (e-cigs) are an increasingly popular alternative to smoking, helping to prevent relapse in those trying to quit and with the potential to reduce harm as they are likely to be safer than standard cigarettes. Many women return to smoking in the postpartum period having stopped during pregnancy, and while this can affect their decisions about breastfeeding, little is known about women’s opinions on using e-cigs during this period.

Objective
The aim of this study is to explore online forum users’ current attitudes, motivations, and barriers to postpartum e-cig use, particularly as a breastfeeding mother.

Methods
Data were collected via publicly accessible (identified by Google search) online forum discussions, and a priori codes identified. All transcripts were entered into NVivo for analysis, with a template approach to thematic analysis being used to code all transcripts from which themes were derived.

Results
Four themes were identified: use, perceived risk, social support and evidence, with a number of subthemes identified within these. Women were using e-cigs to prevent postpartum return to smoking, but opinions on their safety were conflicting. They were concerned about possible transfer of harmful products from e-cigs via breastmilk and secondhand exposure, so they were actively seeking and sharing information on e-cigs from a variety of sources. Although some women were supportive of e-cig use, others provided harsh judgement for mothers who used them.

Conclusions
E-cigs have the potential to reduce the number of women who return to smoking in the postpartum period and potentially improve breastfeeding rates, if breastfeeding mothers have access to relevant and reliable information. Health care providers should consider discussing e-cigs with mothers at risk of returning to smoking in the postpartum period.
Pengaruh Proses Pelaporan Dan Penyetoran Pajak Serta Kepuasan Dan Kepatuhan Dalam Wajib Pajak Pribadi Kabupaten Sleman Terhadap Ketahanan Ekonomi Wilayah
Authors: Ferdiana Diki , Laksmi Ayu Chairina 
Published: March 2019

ABSTRACT This study examinedthe influence of the process of reporting and depositing taxes as well as satisfaction and compliance in personal taxpayers in Sleman regency against economic resilience. The purpose of this study was to analyzed the influence of the process of reporting and depositing taxes and taxpayer compliance and compliance with economic resilience.This research was an empirical research by taking samples of taxpayers in Sleman District. Survey data were analyzed statistically using descriptive method and Structural Equation Modeling (SEM) with the help of computer program AMOS v22. The results showed that the process of reporting and depositing taxes and satisfaction and compliance in taxpayershad posistive influence, which had a significant impact on the economic resilience of the region. This could be said as a form of economic resilience of the region which was the basis of national resilienceABSTRAK Penelitian ini mengkaji tentang pengaruh proses pelaporan dan penyetoran pajak serta kepuasan dan kepatuhan dalam wajib pajak pribadi di Kabupaten Sleman terhadap ketahanan ekonomi. Tujuan penelitian ini untuk menganalisis pengaruh proses pelaporan dan penyetoran pajak serta kepuasan dan kepatuhan wajib pajak terhadap ketahanan ekonomi.Penelitian ini merupakan penelitian empiris dengan mengambil sampel para wajib pajak di Kabupaten Sleman. Data survei dianalisis secara statistik menggunakan metode deskriptif dan Structural Equation Modeling (SEM) dengan bantuan program komputer AMOS v22.Hasil penelitian menunjukkan bahwa proses pelaporan dan penyetoran pajak serta kepuasan dan kepatuhan dalam wajib pajak berpengaruh posistif, yang berdampak signifikan terhadap ketahanan ekonomi wilayah. Hal ini dapat dikatakan sebagai wujud dari ketahanan ekonomi wilayah yang merupakan dasar dari ketahanan nasional.
Treatment patterns and outcomes for patients with unresectable stage III and metastatic melanoma in the USA
Authors: Tarhini Ahmad , Atzinger Christopher , Gupte-Singh Komal , Johnson Courtney , Macahilig Cynthia , Rao Sumati 
Published: March 2019

Aim:
To describe treatment patterns and outcomes of patients with unresectable stage III and metastatic/stage IV melanoma.
Materials & methods:
An observational retrospective chart review of patients diagnosed with advanced melanoma before 1 November 2015 who initiated a new line of therapy (LOT) from 1 January 2015 to 31 May 2016.
Results:
Among 487 patients, ipilimumab monotherapy (27.5%) was the most common first line of therapy (1LOT) in 2015, surpassed by nivolumab monotherapy (21.5%) in 2016. 12-month survival was ≥80.1%; proportions were highest forpatients treated with nivolumab + ipilimumab (86.6%). All treatments relatively well tolerated in real-world setting and adverse events were consistent with the previously reported safety profiles.
Conclusion:
This study provides important insights into real-world advanced melanoma treatment patterns and demonstrates encouraging treatment safety and patient survival data.
Intento suicida y psicosis debida a déficit de vitamina B12, a propósito de un caso
Authors: Morillo de Nieto Zuleika , Guzmán Esquea Deseado , Ortiz Yosira 
Published: March 2019

Introducción: El folato y la vitamina B12 juegan un papel importante en el correcto desarrollo, diferenciación y funcionamiento del Sistema Nervioso Central. Intervienen en la producción de mielina y son indispensables para numerosas reacciones que implican la metilación y biosíntesis de ácidos nucleicos, además de intervenir en la síntesis de proteínas, neurotransmisores, ácidos grasos y fosfolípidos. Su deficiencia se asocia a alteraciones cognitivas, irritabilidad, depresión, psicosis, demencia, entre otras.
Material y Métodos: En este trabajo se presenta el caso de una joven de 17 años, sin antecedentes mórbidos conocidos, que presentó cuadro de un mes de evolución, caracterizado por intento suicida, alucinaciones visuales y auditivas, idea delirante de daño tipo persecutoria, cefalea y parestesias en miembros inferiores. Ingresada en unidad de psiquiatría y consultada por departamento de neurología.
Se le realizaron analíticas y estudios especializados que incluían hemograma, glicemia, perfil renal, hepático, virales, electrolitos, perfil tiroideo, panel 6, tomografía de cráneo y EEG, sin evidencia patológica. Posteriormente con vitamina B12 y ácido fólico, evidenciando niveles de Vit B12 reducidos (110pg-ml), iniciamos la reposición de vitamina B12 intramuscular y añadimos Risperidona 3 mg cada 24 horas.
Conclusión: La paciente presentó remisión total de los síntomas, a partir del tratamiento de Vitamina B12 y los controles pertinentes del departamento de psiquiatría y hematología.
Risk Factors for Kidney Disease in Type 1 Diabetes
Authors: Perkins Bruce A. , Bebu Ionut , de Boer Ian H. , Molitch Mark , Tamborlane William , Lorenzi Gayle , Herman William , White Neil H. , Pop-Busui Rodica , Paterson Andrew D. , Orchard Trevor , Cowie Catherine , Lachin John M. ,   on behalf of the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group
Published: March 2019

OBJECTIVE
In type 1 diabetes (T1D), the course of microalbuminuria is unpredictable and timing of glomerular filtration rate (GFR) loss is uncertain. Thus, there is a need to identify the risk factors associated with the development of more advanced stages of kidney disease through large, long-term systematic analysis.

RESEARCH DESIGN AND METHODS
Multivariable Cox proportional hazards models assessed the association of baseline and time-dependent glycemic and nonglycemic risk factors for incident macroalbuminuria and reduced estimated GFR (eGFR; defined as &lt;60 mL/min/1.73 m2) over a mean of 27 years in the Diabetes Control and Complications Trial (DCCT) cohort.

RESULTS
Higher mean HbA1c (hazard ratio [HR] 1.969 per 1% higher level [95% CI 1.671–2.319]) and male sex (HR 2.767 [95% CI 1.951–3.923]) were the most significant factors independently associated with incident macroalbuminuria, whereas higher mean triglycerides, higher pulse, higher systolic blood pressure (BP), longer diabetes duration, higher current HbA1c, and lower mean weight had lower magnitude associations. For incident reduced eGFR, higher mean HbA1c (HR 1.952 per 1% higher level [95% CI 1.714–2.223]) followed by higher mean triglycerides, older age, and higher systolic BP were the most significant factors.

CONCLUSIONS
Although several risk factors associated with macroalbuminuria and reduced eGFR were identified, higher mean glycemic exposure was the strongest determinant of kidney disease among the modifiable risk factors. These findings may inform targeted clinical strategies for the frequency of screening, prevention, and treatment of kidney disease in T1D.
PERKEMBANGAN ARSITEKTUR VERNAKULAR ATONI; KASUS STUDI: KAWASAN ISTANA KERAJAAN AMARASI DI TEUNBAUN, KABUPATEN KUPANG
Authors: El Boru Jeky 
Published: March 2019

Abstract: This research concerns about the development of vernacular Atonian architecture in an architecture and urban context. The samples were taken from some villages that are still applying Atonian architecture and still have been changed until now. The method used in data collecting are observation, interview, and from the literature sources. The analytical method used is qualitative description which is concern about any sources of research in vernacular Atonian culture. It is compared to the current condition of Atonian culture by using the categorization of cultural forms which were mentioned by Koentjaraningrat. This research aims is to find out the changes of architecture and urban context in the development of vernacular Atonian architecture, The result of this research is the changes on cultural forms which can be seen in three manifestation, that are the changes in idea (cultural system), activities, and artifacts as physical things in building and urban planning context.Keywords: development, architecture and urban, vernacular Atonian architectureAbstrak: Tulisan ini membahas mengenai perkembangan arsitektur vernakular Atoni dilihat dari sisi arsitektur dan kawasan. Kasus studi penelitian ini menekankan pada kawasan kampung yang masih mengunakan arsitektur Atoni dan juga yang telah mengalami perubahan. Metode pengumpulan data dilakukan melalui observasi, wawancara, dan melihat berbagai sumber pustaka, sedangkan metode analisis yang diterapkan, yakni deskripsi kualitatif dengan melihat berbagai sumber penelitian kebudayaan vernakular Atoni yang kemudian dibandingkan dengan perubahan yang terjadi pada kebudayaan Atoni saat ini dengan mengacu pada kategorisasi wujud kebudayaan yang diungkapkan oleh Koentjaraningrat. Tujuan penelitian ini adalah mengetahui perubahan arsitektur dan kawasan dalam perkembangan arsitektur vernakular Atoni, dan hasil dari penelitian ini adalah perubahan kebudayaan dilihat dari tiga wujud yakni perubahan pada tata cara, aktivitas, dan benda-benda berupa bangunan dan tata kawasan.Kata kunci: perkembangan, arsitektur dan kawasan, arsitektur vernakular Atoni
PEMANFAATAN MARKA JALAN UNTUK MENGATUR BATAS TERITORIAL PERILAKU PADA PASAR MINGGU PAGI (SUNDAY MORNING MARKET) UNIVERSITAS GADJAH MADA YOGYAKARTA (Studi Kasus : Jalan Olahraga Universitas Gadjah Mada Yogyakarta)
Authors: Ricardo David 
Published: March 2019

Abstract: This Research is one of methods to figure out the benefits from the use of marking road. A special handling is needed to the violations of Marking Road especially for populated area that located on lack of attention area. Sunday morning market of University of Gadjah Mada has tight activities every Sunday morning and Olahraga street is the study sample that represent other streets. This research using qualitative methods by gathering data field and interview to obtain results such as site size, history, behavior setting, behavior mapping, and personal space. The use of marking road must be related to territorial division of activities such as function and activity that is happening. Territory happened through a different process every its object. There are two divisions of territory for Sunday Market Morning that are Primary Territory and Secondary Territory. Primary Territory includes kiosk traders, parking attendants, and visitors. On the other hand, Secondary territory is a space that is used together such as secondary road or the divisor road. After the division of territories is obtained then the data is analyzed to get some alternatives. The alternatives are compared to get the pattern of territories that can be arranged through the use of Marking Road.Keywords: Marking Road, Territorial, Sunday Morning Market of Gadjah Mada University Abstrak: Penelitian ini merupakan salah satu cara untuk mengetahui manfaat dari penggunaan marka jalan. Pelanggaran terhadap marka jalan perlu penanganan khusus terutama daerah-daerah padat yang terdapat pada jalur jalan lingkungan yang kurang menjadi perhatian. Pasar Minggu Pagi (Sunday Morning Market) Universitas Gadjah Mada Yogyakarta termasuk memiliki kegiatan padat setiap minggu pagi dan jalan olahraga sebagai sampel penelitian mewakili jalan yang lain. Penelitian ini menggunakan metode kualitatif dengan mengumpulkan data lapangan dan wawancara sehingga mendapatkan data seperti ukuran site, sejarah, behavior setting, behavior mapping, dan personal space. Penggunaan marka jalan pasti berhubungan dengan pembagian batas teritori kegiatan seperti fungsi dan aktivitas yang terjadi. Teritori terjadi melalui proses yang berbeda-beda tiap objeknya. Pada Sunday Morning Market terdapat pembagian dua teritori yaitu primary territory dan secondary territory. Primary territory meliputi pedagang kios, pelaku parkir, dan pengunjung. Sedangkan secondary territory merupakan ruang yang dipakai bersama seperti jalan sekunder ataupun jalan pembagi. Setelah didapatkan pembagian teritorinya maka dianalisis dan mendapatkan beberapa alternatif. Alternatif tersebut dibandingkan sehingga mendapatkan pola teritori yang dapat diatur melalui penggunaan marka jalan.Kata kunci: Marka Jalan, Teritorial, Pasar Minggu Pagi Universitas Gadjah Mada