bluuebunny/crossref_metadata_2025_split huggingface dataset:
Operative And Non-operative Management Of Osteochondritis Dissecans In The Knee Of Skeletally Immature Patients: Rates Of Persistent Knee Pain, Osteoarthritis, And Arthroplasty At Mean 14- Years Follow-up
Authors: Hevesi Mario , Sanders Thomas L. , Pareek Ayoosh , Milbrandt Todd , Levy Bruce A. , Saris Daniël B. , Krych Aaron John 
Published: July 2018

Objectives: The purpose of this study was to report long-term follow-up of skeletally immature OCD lesions treated operatively and non-operatively and determine risk factors for persistent knee pain at final follow-up. Methods: A large, geographic database of over 500,000 patients was reviewed in this case series to identify and confirm patients with OCD of the knee. Presenting radiographs and MRI were reviewed. Clinical course including operative management, persistent knee pain, and conversion to TKA were obtained and analyzed through review of clinical and operative notes. Results: 95 skeletally immature patients (70 males, 25 females) with OCD lesions diagnosed at a mean age of 13 years (range: 7-16) were followed for a mean of 14 years (range: 2-40). 53 patients (56%) were treated operatively and 42 patients (44%) were treated non-operatively. At final follow up, 13 patients with a mean age of 30 years noted persistent knee pain, 8 (15%) treated operatively versus 5 (12%) treated non-operatively. Risk factors for knee pain were female gender, patellar lesion location, and unstable lesions (Table 1). Four patients (8%) treated operatively and two (5%) treated non-operatively developed symptomatic osteoarthritis at a mean of 28.6 years following diagnosis. One patient treated operatively and two treated non-operatively converted to TKA at a mean of 37 years following diagnosis. Mean age at TKA was 52 years, significantly younger than that observed for primary TKA at our institution (p = 0.004). Conclusion: Patients with skeletally immature OCD lesions have an estimated 14% rate of persistent knee pain, 6% risk of symptomatic osteoarthritis, and 3% risk of conversion to TKA at a mean of 14 years following time of diagnosis. Female patients, patellar lesions, and unstable lesions demonstrated increased risk of persistent knee pain at final follow-up. Patients with OCD of the knee convert to TKA at a significantly younger age than that of the general primary TKA population. [Table: see text]
Trans-osseous versus Anchor Repair of Acute Patellar Tendon Ruptures
Authors: O’Dowd James A. , Lehoang David , Butler Rebecca K. , De Witt David , Mirzayan Raffy 
Published: July 2018

Objectives: Patellar tendon ruptures are relatively uncommon injuries. They require prompt diagnosis and surgical repair to restore the extensor mechanism of the knee. The gold standard procedure is a suture repair of the tendon, passed through trans-osseous tunnels, and tying of the sutures on the superior pole of the patella. Suture anchors have gained popularity with a recent cadaveric study demonstrating significantly less gap formation during cyclic loading and significantly higher ultimate failure loads. We present the largest series of patellar tendon repairs and compare the clinical outcomes and complications of trans-osseous (TO) and anchor (A) repair types. Methods: All patients who underwent a primary repair of a traumatic patellar tendon rupture within 45 days of injury, between 2007 and 2016, were retrospectively reviewed. Surgeries were performed at a multi-surgeon (114 surgeons), multi-center (13 centers) community-based integrated health care system. Patients with prior knee surgery, use of graft, patellar debridement for tendonitis, inferior pole avulsion fracture, concurrent knee surgery with other procedures were excluded. Patient demographic information, repair type, complications, and time from surgery to release from medical care were recorded. Results: 361 patients (374 knees) met our inclusion criteria. 13 had bilateral repairs during our study period and an additional 8 had a contralateral repair prior to our study period, for a bilateral incidence at 5.8%. The average age was 39.8 years (9 to 86 years). There were 341 males (94.5%). The most common mechanism of injury was basketball (47%), fall (19.5%), football (5.0%), and soccer (4.8%). Average time from injury to surgery was 6.3 days (range: 1- 45 days). There were 321 TO and 53 A repairs. There was no significant difference in the mean age (P=0.27), gender (P=0.79), tourniquet time (P=0.93), or BMI (P=0.78) between the two groups. There was a significant difference in re-rupture between (24 of 321) TO (7.5%) and (0 of 53) A (0%) (P=0.034). Using logistic regression, we found that TO had 3.244 times the odds of re-operation as those with A (95% CI: 0.757, 13.895. p-value: 0.1129) but did not reach signficance. The infection rate was 7.5% for A and 1.6% for TO (P= 0.160). There was no difference in time to release from medical care, 18.4 weeks for and 17.1 weeks (P=0.92). Conclusion: Compared to Anchors, primary repair of patellar tendon ruptures with trans-osseous repair had a significantly higher re-rupture rate, but there was no difference in re-operation rate, infection, or release from medical care.
Patellar Tendon Thickness and Failure After Anterior Cruciate Ligament Reconstructions with Bone-Patella Tendon-Bone Autograft
Authors: Roach Ryan , Kramarchuk Mark , Pham Hien , Mastio Michele , Dai Amos , Alaia Michael Joseph , Gonzalez-Lomas Guillem 
Published: July 2018

Objectives: The purpose of this study was to determine if patellar tendon (PT) thickness measured on pre-operative magnetic resonance imaging (MRI) is a risk factor for failure after anterior cruciate ligament reconstruction (ACLR) using bone-patella tendon-bone (BTB) autograft. Methods: 18 patients [age (mean 96 Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:”Table Normal”; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow: yes; mso-style-priority:99; mso-style-parent:”“; mso-padding-alt:0in 5.4 pt 0in 5.4 pt; mso-para-margin:0in; mso-para-margin-bottom:.0001 pt; mso-pagination: widow-orphan; font-size:11.0 pt; mso-bidi-font-size:12.0 pt; font-family: Helvetica;} ± standard deviation) 21.5 ± 4.99years] that underwent an ACLR with BTB autograft and returned for revision ACLR between July 2005-January 2017 at our institution were included in the study. Failures were age-, sex-, height-, and weight-matched to 36 control (age 21.5 ± 4.99years) BTB-ACLR patients that have not required revision at a minimum of 2-years follow-up. Demographic data and mechanism of injury were recorded from patients’ medical records. PT thickness was measured at 3 points (5 mm lateral to the center, center, and 5 mm medial to the center) each at the level of the inferior pole of the patella (IPP), midpoint (MP), and insertion to tibial tubercle (ITT) on pre-operative axial-cut MRI. Results: All ACLR failures occurred after a non-contact pivot-shift type injury. Mean time between primary ACLR and revision was 2.4 ± 2.4 years and mean follow-up time was 3.1 ± 0.9 years in the control group. Patients with a failed ACLR had significantly thicker PTs at the IPP (lateral: 4.66 ± 1.47 vs 3.96 ± 0.66 mm; central: 5.39 ± 1.49 vs 4.51 ± 1.04 mm; medial: 5.51 ± 1.52 vs 4.59 ± 1.05 mm) and MP (lateral: 4.50 ± 0.83 vs 4.12 ± 0.54 mm; central: 4.83 ± 0.80 vs 4.43 ± 0.59 mm; medial: 4.57 ± 0.88 vs 4.13 ± 0.59 mm). There were no significant differences in PT thickness at the ITT. PT width tended to be larger in the failure cohort but this was not statistically significant (IPP: 32.2 ± 4.6 vs 29.8 ± 4.3 mm; MP: 31.3 ± 4.9 vs 29.5 ± 3.8 mm; ITT: 27.7 ± 3.7 vs 26.2 ± 2.9 mm). Conclusion: Contrary to conventional wisdom, we found that BTB autograft ACLR failures had significantly thicker patellar tendons at the inferior pole of the patella and midpoint. Further studies are need to investigate possible causes for this inverse correlation, such as poor histological tendon quality or mechanical impingement due to increased tendon size.
Accuracy of MRI and Varus Stress Radiographs in Diagnosing Fibular Collateral Ligament Injuries
Authors: Provencher Matthew T. , Kane Patrick W. , DePhillipo Nicholas N. , Cinque Mark , Moatshe Gilbert , Murphy Colin , Sanchez Anthony , LaPrade Robert F. 
Published: July 2018

Objectives: To evaluate the diagnostic accuracy of magnetic resonance imaging and varus stress radiographs for FCL tears, and compare these modalities to intraoperative findings. Methods: All patients who underwent an isolated FCL or combined ACL/FCL reconstruction by a single surgeon between 2010 and 2017 with preoperative varus stress radiographs and MRI were included in this study. A control group was comprised of patients with an MRI and intact ACL and FCL. Sensitivity and specificity of diagnosing FCL injuries on MRI were determined based on review by a fellowship-trained musculoskeletal radiologist. The sensitivity of diagnosing an FCL injury based on varus stress radiographs was also determined. Furthermore, the ability of both imaging modalities to identify an FCL injury was stratified based on acute versus chronic etiology. Results: A total of 232 patients were included: 98 patients in the FCL tear group and 134 patients in the control group. Varus stress radiographs were determined to be more sensitive in diagnosing FCL injuries compared to MRI, with an overall sensitivity of 70% compared to 66%. Based on chronicity of the injuries, MRI was more accurate for detecting acute FCL injuries than chronic injuries (p=0.002), and varus stress radiographs were more accurate for detecting chronic FCL injuries than acute injuries (p=0.041). Conclusion: To our knowledge, this is the first clinical study to directly compare the diagnostic accuracy of FCL tear detection utilizing MRI and varus stress radiographs in the same patient cohort. While varus stress radiographs appear to have a higher accuracy overall, the results from our study support the use of both varus stress radiographs and MRI in diagnosing FCL injuries, as MRI is more sensitive in diagnosing an acute FCL tear, and varus stress radiographs are more sensitive in diagnosing a chronic FCL tear.
Shoulder Injection Prior to Rotator Cuff Repair is Associated with Increased Risk of Subsequent Surgery
Authors: Traven Sophia , Brinton Daniel , Simpson Kit , Adkins Zachary , Althoff Alyssa , Palsis John Andrew , Slone Harris 
Published: July 2018

Objectives: Corticosteroid injections (CSI) are frequently utilized in the nonoperative management of rotator cuff tears. However, recent literature suggests that injections may reduce biomechanical strength of tendons and ligaments in animal models and increase the risk of postoperative infections following surgery. The goal of this study was to determine if the timing of CSI is associated with an increased risk of reoperation following primary rotator cuff repair (RCR). Methods: A retrospective analysis of claims data of privately-insured subjects from the MarketScan® database for the years 2010-2014 was conducted. A cohort of subjects aged 18-64 who were diagnosed with a rotator cuff tear and underwent repair in 2011 was identified. Multivariable logistic regression models were used to compare the odds of reoperation between groups. Results: A total of 4,959 subjects with an arthroscopic RCR were identified. Of this, 550 subjects required reoperation within the following 3 years. Patients who had a CSI within 6 months preceding the RCR were at a much higher risk of undergoing reoperation: 0-3 months prior, AOR 1.536 (95% CI: 1.201 -1.965); 3-6 months, AOR 1.843 (95% CI: 1.362-2.494); and 6-12 months AOR 1.339 (95% CI: 0.914 -1.962). Of those patients that underwent a reoperation, the most common surgery performed was revision rotator cuff repair followed by arthroscopic debridement (48.5% versus 38.9%, respectively). Conclusion: Patients who had received a CSI within 6 months prior to RCR were much more likely to undergo a subsequent reoperation within the following 3 years. These odds diminished as more time passed between CSI and primary repair. Consideration should therefore be given to delaying primary rotator cuff repair for 6 months following injection. [Table: see text][Figure: see text]
Full width at half maximum of low-angle basal phyllosilicate X-ray diffraction reflections: fitted peaks vs. diffraction traces
Authors: Kisch Hanan J. 
Published: July 2018

ABSTRACTBernard Kübler measured illite ‘crystallinity’, the half-height width or full width at half maximum (FWHM) of the X-ray diffraction line of illite/mica at 10 Å, directly on the diffraction traces; this procedure has since been followed by the vast majority of workers. However, some workers have recently measured the FWHM of the fitted Pearson VII function rather than on the diffraction traces. The FWHM of this function for low-angle phyllosilicate diffraction peaks (FWHM*PVII) is almost consistently ‘broader’ than those measured directly on the diffraction trace profiles (FWHMtrace) by up to 0.08°Δ2θ for the broader peaks. The Pearson VII function shows gentle curvature (‘smoothing’) at its tops and fast fading of the tails relative to virtually all 10 Å diffraction traces. The broad FWHM*PVII results from the consequent lowering/’under-fitting’ of the peak tops and the upper tails and compensatory broadening/’over-fitting’ of the intermediate peak flanks. FWHM*PVII ‘contraction’ with respect to FWHMtrace and enhancement of the peak maximum is found on traces of muscovite strips. The fitting reliabilities of the Cauchy function are almost invariably better than those of the Pearson VII function. Their FWHM*Cauchy values are narrower for both the illite/mica 10 Å and the chlorite 7 Å reflections; although they still differ somewhat from the FWHMtrace, they are much closer, usually within 0.02°Δ2θ. This markedly lesser broadening of FWHM* of the Cauchy of the Pearson VII function is the result of its stronger top curvature and notably faster tail fading (less ‘smoothening’). For higher-angle mica peaks, the FWHM* values of the Pearson VII and Cauchy functions converge, usually differing only by 0.01–0.03°Δ2θ for the 5 Å peak, and even less for the 3.3 Å peak. It is therefore strongly recommended that FWHM values of the illite/mica 10 Å reflections be measured on the diffraction traces rather than on fitted functions. Where peak fitting is unavoidable (e.g. in order to separate the contributions of adjoining, partly resolved or unresolved reflections on broadened 10 Å reflections), Cauchy rather than Pearson VII functions should be used.
Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma
Authors: Song Tammy Linlin , Nairismägi Maarja-Liisa , Laurensia Yurike , Lim Jing-Quan , Tan Jing , Li Zhi-Mei , Pang Wan-Lu , Kizhakeyil Atish , Wijaya Giovani-Claresta , Huang Da-Chuan , Nagarajan Sanjanaa , Chia Burton Kuan-Hui , Cheah Daryl , Liu Yan-Hui , Zhang Fen , Rao Hui-Lan , Tang Tiffany , Wong Esther Kam-Yin , Bei Jin-Xin , Iqbal Jabed , Grigoropoulos Nicholas-Francis , Ng Siok-Bian , Chng Wee-Joo , Teh Bin-Tean , Tan Soo-Yong , Verma Navin Kumar , Fan Hao , Lim Soon-Thye , Ong Choon-Kiat 
Published: July 2018

Key Points
Alterations in JAK/STAT signaling pathway are highly prevalent in PTCL and NKTL, where STAT3 and TP53 are the most frequently mutated genes. STAT3 activation drives PD-L1 expression in NKTL, providing a rationale to combine STAT3 inhibitors with immune checkpoint inhibitors.
Validation of the 2017 revision of the WHO chronic myelomonocytic leukemia categories
Authors: Loghavi Sanam , Sui Dawen , Wei Peng , Garcia-Manero Guillermo , Pierce Sherry , Routbort Mark J. , Jabbour Elias J. , Pemmaraju Naveen , Kanagal-Shamanna Rashmi , Gur H. Deniz , Hu Shimin , Zuo Zhuang , Medeiros L. Jeffrey , Kantarjian Hagop M. , Khoury Joseph D. 
Published: July 2018

Key Points
Validation of the WHO 2017 CMML categories supports distinguishing MP-CMML from MDS–CMML. The prognostic value of the new 3-tiered blast-based CMML stratification scheme is limited.
Prevalence of dengue fever virus antibodies and associated risk factors among residents of El-Gadarif state, Sudan
Authors: Eldigail Mawahib H. , Adam Gamal K. , Babiker Rabie A. , Khalid Fatima , Adam Ibrahim A. , Omer Osama H. , Ahmed Mohamed E. , Brair Sara L. , Haroun Eltahir M. , AbuAisha Hassan , Karrar Abdelrahim E. , Abdalla Hamid S. , Aradaib Imadeldin E. 
Published: July 2018

Abstract
Background
Dengue fever, caused by dengue virus (DENV), has become one of the most important mosquito-borne viral diseases with a steady rise in global incidence, including the Sudan. Sporadic cases and frequent acute febrile illness outbreaks, compatible with Dengue fever, have been reported in El-Gadarif State, Sudan. However, diagnosis was based almost exclusively on clinical signs without confirmatory laboratory investigations. Despite the magnitude of the problem in El-Gadarif State, no information is currently available with regard to the epidemiology of the disease in this State. El-Gadarif State is one of the largest commercial centers in the Sudan. The objective of the present investigation is to estimate the prevalence of DENV antibodies, and determine the potential risk factors associated with seropositivity among residents of El-Gadarif State.

Methods
A cross sectional study was conducted in a total of 701residents randomly selected from all 10 localities in El-Gadarif State. The sera from the 701 residents were tested for the presence of DENV-specific immunoglobulin G (IgG) antibodies using a commercially available Anti-dengue IgG enzyme-linked immunosorbent assay (ELISA).

Results
Among the 701 residents, 334 residents (47.6%) were seropositive for DENV. Mosquito control (OR = 2.73, CI = 1.37–5.87, p-value = 0.001); low income (OR = 2.31, CI: 1.71–6.36, p value = 0.032); sleeping out-doors (OR = 3.73, CI = 2.63–6.23, p-value = 0.013), and localities were determined as potential risk factors for contracting DENV infection.

Conclusions
The prevalence rate of DENV antibodies among residents of El-Gadarif State is significantly high (47.6%). Further epidemiologic studies including, distribution of mosquito vectors and implementation of improved surveillance are urgently warranted for better prediction and prevention of a possible DENV outbreak in El-Gadarif State, Sudan.
The book on how to make all the colour paints for illuminating books: unravelling a Portuguese Hebrew illuminators’ manual
Authors: Melo Maria J. , Castro Rita , Nabais Paula , Vitorino Tatiana 
Published: July 2018

Abstract

The book on how to make all the colour paints for illuminating books invites readers to step inside the workshop of a fifteenth century illuminator in Portugal. This illuminator was the carrier of a tradition on how to make colours with ‘which you can illuminate or paint or capitalize or write’ that dates back, at least, to the thirteenth century. This unique knowledge and know-how was carefully preserved in Portuguese language, in Hebrew characters, in a collection of texts now known as Ms. Parma 1959 (Parma, Italy, Biblioteca Palatina, MS 1959, folios 1r–20r). Its ultimate purpose was possibly to assist on the production of Hebrew Bibles, where the precision of the text would have been illuminated by the colours described in this ‘book of all colour paints’. This medieval treatise describes the main steps and ingredients for producing painting materials, such as mosaic gold, red lead, verdigris, brazilwood lake pigments, lac dye red, vermilion, parchment glue, among others. It also instructs on the binding media that should be used to produce the colour paints. In this paper, we will discuss the technical aspects relevant for the success of the making of the painting materials and of the experimentation of this remarkable text, copied in the fifteenth century.
Theranostics and contrast agents for magnetic resonance imaging
Authors: Jeong Yohan , Hwang Hee Sook , Na Kun 
Published: July 2018

Abstract

Background
Magnetic resonance imaging is one of the diagnostic tools that uses magnetic particles as contrast agents. It is noninvasive methodology which provides excellent spatial resolution. Although magnetic resonance imaging offers great temporal and spatial resolution and rapid in vivo images acquisition, it is less sensitive than other methodologies for small tissue lesions, molecular activity or cellular activities. Thus, there is a desire to develop contrast agents with higher efficiency. Contrast agents are known to shorten both T1 and T2. Gadolinium based contrast agents are examples of T1 agents and iron oxide contrast agents are examples of T2 agents. In order to develop high relaxivity agents, gadolinium or iron oxide-based contrast agents can be synthesized via conjugation with targeting ligands or functional moiety for specific interaction and achieve accumulation of contrast agents at disease sites.

Main body
This review discusses the principles of magnetic resonance imaging and recent efforts focused on specificity of contrast agents on specific organs such as liver, blood, lymph nodes, atherosclerotic plaque, and tumor. Furthermore, we will discuss the combination of theranostic such as contrast agent and drug, contrast agent and thermal therapy, contrast agent and photodynamic therapy, and neutron capture therapy, which can provide for cancer diagnosis and therapeutics.

Conclusion
These applications of magnetic resonance contrast agents demonstrate the usefulness of theranostic agents for diagnosis and treatment.
Q-compensated acoustic impedance inversion of attenuated seismic data: Numerical and field-data experiments
Authors: Chai Xintao , Tang Genyang , Wang Fangfang , Gu Hanming , Wang Xinqiang 
Published: July 2018

Acoustic impedance (AI) inversion is of great interest because it extracts information regarding rock properties from seismic data and has successful applications in reservoir characterization. During wave propagation, anelastic attenuation and dispersion always occur because the subsurface is not perfectly elastic, thereby diminishing the seismic resolution. AI inversion based on the convolutional model requires that the input data be free of attenuation effects; otherwise, low-resolution results are inevitable. The intrinsic instability that occurs while compensating for the anelastic effects via inverse [Formula: see text] filtering is notorious. The gain-limit inverse [Formula: see text] filtering method cannot compensate for strongly attenuated high-frequency components. A nonstationary sparse reflectivity inversion (NSRI) method can estimate the reflectivity series from attenuated seismic data without the instability issue. Although AI is obtainable from an inverted reflectivity series through recursion, small inaccuracies in the reflectivity series can result in large perturbations in the AI result because of the cumulative effects. To address these issues, we have developed a [Formula: see text]-compensated AI inversion method that directly retrieves high-resolution AI from attenuated seismic data without prior inverse [Formula: see text] filtering based on the theory of NSRI and AI inversion. This approach circumvents the intrinsic instability of inverse [Formula: see text] filtering by integrating the [Formula: see text] filtering operator into the convolutional model and solving the inverse problem iteratively. This approach also avoids the ill-conditioned nature of the recursion scheme for transforming an inverted reflectivity series to AI. Experiments on a benchmark Marmousi2 model validate the feasibility and capabilities of our method. Applications to two field data sets verify that the inversion results generated by our approach are mostly consistent with the well logs.