bluuebunny/crossref_metadata_2025_split huggingface dataset:
The three-domain impact framework for characterizing impact of patient involvement in health technology assessment
Authors: Lopez Gousset Veronica , Silveira Silva Aline , Holtorf Anke-Peggy , Toledo-Chávarri Ana , Single Ann 
Published: November 2024

Abstract

Objectives
Evaluating the impact of patient involvement in health technology assessments (HTA) may help improve practices and avoid ineffective activities. Evaluation, however, continues to be infrequent, inconsistent, and often only relates to process quantity or quality. The Patient and Citizen Involvement in HTA Interest Group (PCIG) within Health Technology Assessment International set out to contextualize this impact to support evaluation.

Methods
Given the lack of established methodology to measure impact, the team performed a qualitative analysis of first-hand accounts about perceived changes in HTA due to involvement of patient stakeholders. A questionnaire was developed, piloted, and rolled out to collect personal perspectives from stakeholders with relevant experience. The stories were analyzed in the aggregate to identify themes in the data.

Results
From January 2019 to September 2021, twenty-four responses were collected through PCIG’s network. Responses (including one joint industry-HTA body submission) came from patient representatives (12), HTA bodies (11), and industry representatives (2) from North America (5), South America (3), Europe (13), and Asia Pacific (3). Based on themes commonly reported, a three-domain framework for evaluating impact is proposed: impact on basis of HTA result or recommendation, impact on HTA body, and impact on patient participants. The framework includes components under each domain to support reporting.

Conclusions
Using the Three-Domain Impact Framework may be useful in identifying, evaluating, and communicating the value of patient involvement in HTA. Enhancing and increasing reporting practices may improve transparency and facilitate process improvements for meaningful integration of patient stakeholders into HTA appraisals across jurisdictions.
‘Par mesure de prudence’. Flood prevention and river regulation in Demer-Dijle confluence area (NE Belgium), 1840s–1880s
Authors: Lathouwers Eline , Segers Yves , Verstraeten Gert 
Published: November 2024

Abstract
This article analyses the views of experts and political discourse on river regulation, its objectives, and flood prevention in the rural Demer-Dijle catchment areas, the 1840s–1880s – a period marked by climatological extremes and agricultural transition. Via a close read of state archives and parliamentary discussions, we unravel different opinions and interests and find that not all flooding was unwanted. While the Ministry of Public Works, at first, aimed to better regulate water discharge and to improve watercourses for navigational purposes, it later prioritised agricultural interests. However, managing rivers coherently and efficiently was challenging because river powers were dispersed over ministerial departments, provinces, and municipalities that made coordinating upstream and downstream river works difficult. Floods often resulted in the drawing up of new plans, but their implementation often failed to materialise because the government had other worries and insufficient resources available while parliamentarians prioritised the interests of their constituencies.
The Value of Life and Reproductive and Professional Autonomy
Authors: Frith Lucy 
Published: November 2024

Abstract
This article considers John Harris’ work on autonomy, specifically reproductive autonomy, outlined in The Value of Life and developed throughout his career. Harris often used the concept of reproductive autonomy to make the case for liberal approaches to developments in reproductive and genetic technologies. Harris argued that reproductive autonomy should be highly valued, and therefore we need compelling arguments to justify limiting it in anyway. When discussing reproductive autonomy, Harris focused mainly on restrictions on the potential users of reproductive technologies autonomy, that is, prospective parents. This article extends the discussion of autonomy and the appropriate limits to individuals exercising their autonomy to medical professionals working in this area. Given reproductive technologies have become part of routine medical practice, this article considers whether the current restrictions on both patients and clinicians, as imposed by regulators and professional guidelines, remain ethically justified.
Association of growth differentiation factor 9 expression with nuclear receptor and basic helix-loop-helix transcription factors in buffalo oocytes during in vitro maturation
Authors: Jain Tripti , Jain Asit , Goswami Surender Lal , Roy Bhaskar , De Sachinandan , Kumar Rakesh , Datta Tirtha Kumar 
Published: November 2024

AbstractGrowth differentiation factor 9 (GDF9) is an oocyte-specific paracrine factor involved in bidirectional communication, which plays an important role in oocyte developmental competence. In spite of its vital role in reproduction, there is insufficient information about exact transcriptional control mechanism of GDF9. Hence, present study was undertaken with the aim to study the expression of basic helix-loop-helix (bHLH) transcription factors (TFs) such as the factor in the germline alpha (FIGLA), twist-related protein 1 (TWIST1) and upstream stimulating factor 1 and 2 (USF1 and USF2), and nuclear receptor (NR) superfamily TFs like germ cell nuclear factor (GCNF) and oestrogen receptor 2 (ESR2) under three different in vitro maturation (IVM) groups [follicle-stimulating hormone (FSH), insulin-like growth factor-1 (IGF1) and oestradiol)] along with all supplementation group as positive control, to understand their role in regulation of GDF9 expression. Buffalo cumulus–oocyte complexes were aspirated from abattoir-derived ovaries and matured in different IVM groups. Following maturation, TFs expression was studied at 8 h of maturation in all four different IVM groups and correlated with GDF9 expression. USF1 displayed positive whereas GCNF, TWIST1 and ESR2 revealed negative correlation with GDF9 expression. TWIST1 & ESR2 revealing negative correlation with GDF9 expression were found to be positively correlated amongst themselves also. GCNF & USF1 revealing highly significant correlation with GDF9 expression in an opposite manner were found to be negatively correlated. The present study concludes that the expression of GDF9 in buffalo oocytes remains under control through the involvement of NR and bHLH TFs.
Effects of substance exposure on gametes and pre-implantation embryos: a narrative review
Authors: Mehdinejadiani Shayesteh , Khosravizadeh Zahra , Alizadeh Akram , Azad Nahid 
Published: November 2024

AbstractSubstance use refers to the consumption of drugs that have varying degrees of impact on a persons’ physical, mental and emotional well-being. While the adverse health effects of drugs have been extensively documented, further research is needed to understand their impact on fertility. Studies have indicated that substance use affects both the male and female reproductive systems. As substance use is more prevalent among young adults compared with the elderly, it appears that individuals of reproductive age are particularly vulnerable to the reproductive impairments associated with substance use. Although numerous studies have reported detrimental effects of substance use on pregnant women and their foetus during the post-implantation stages, there are limited studies on critical pre-implantation period and gamete stages. In this narrative review, we aimed to focus on the most significant evidence regarding the impact of substances on gametes and pre-implantation embryos.
Anaemia prevalence, its determinants and profile of micronutrient status among rural school adolescent girls aged 14–19 years: a cross-sectional study in Nagpur district, Maharashtra, India
Authors: Dhurde Varsha S , Patel Archana B , Locks Lindsey M , Hibberd Patricia L 
Published: November 2024

Abstract

Objective:
The objective of our study was to determine the prevalence of anaemia among 14–19 years school going girls, risk factors for it and profile of micronutrient status among rural girls from western state of India.

Design:
Using a cross-sectional design, we obtained information on socio-demography, menstruation, dietary habits, knowledge and daily consumption of the government recommended iron and folic acid (IFA) tablets, and anthropometry. Blood was collected to assess Hb, red blood cell indices, serumFe, folate and vitamin B12 levels.

Settings:
Nagpur district, Maharashtra, India.

Participants:
A total of 221 girls aged 14–19 years studying in twenty-four government institutes included.

Results:
57 % girls were anaemic, 84 % had deficiency of one or more micronutrients and 60 % were malnourished based on body mass index (BMI). The prevalence of Fe, vitamin B12 and folate deficiency was 37·7 %, 69·8 % and 1·4 %, respectively. Among anaemic girls, Fe and vitamin B12 deficiency was observed in 45·5 % and 67·5 %, respectively, v. among non-anaemic girls it was 27 % and 73 %, respectively. Fe deficiency was a predictor of anaemia and its severity. Girls residing in non-nuclear family were more likely to have anaemia. The consumption of daily non-vegetarian food and green leafy vegetables was 3 % and 3·6 %, respectively. Only 9 % consumed IFA tablets in the past 2 weeks.

Conclusions:
Anaemia is common in adolescent girls, particularly associated with Fe and vitamin B12 deficiency. There is need to reconsider the approach to prevention of anaemia in adolescent girls, particularly before they become pregnant.
The brilliance of Maria Sklodowska Curie: understanding history is critical to forging the future
Authors: Trombetta Mark , Julian Thomas B. 
Published: November 2024

Abstract
Ask most oncologists (especially radiation oncologists), and you may be hard pressed to find one who professes ignorance of Madame Curie and her historic contributions to medicine. Innumerable publications and media over the past century have correctly memorialised Madame Curie as one of the most brilliant minds in world history. However, do any of us really know the woman and the true extent of her sphere of influence? How, as well, does she fit into modern life and contemporary scientific advancement? Let us try to understand and learn from this complex scientist as more than just one of the most brilliant minds in human history.
Design of a cost-effective intelligent surface structure for field reconfiguration of an antenna
Authors: Ahmed Aijaz , Dubey Satya Kesh 
Published: November 2024

Abstract
This work presents a passive intelligent surface designed at 2.45 GHz that has the capability of transmitting and reflecting electromagnetic waves that are incident upon it. The proposed surface does not require any circuitry or power source to function. Therefore, it makes a cost-effective and simple intelligent surface. It is a simple metallic structure that has embedded waveguide slots on its surface, allowing the waves to couple for transmission. A prototype of the proposed surface is designed using an aluminum foil and analyzed for both transmission and reflection of the wave. Further, the designed surface is investigated for tuning the directionality of the radiated field from the antenna. For this purpose, a coplanar patch antenna is first designed and then combined with the surface to tune the directionality of the radiated field of this antenna. The outcome of the measured performance validates that the proposed surface has the potential capability of field reconfiguration in wireless communication for Wi-Fi, WLAN, and Bluetooth applications.
Topology-based segmentation of 3D confocal images of emerging hematopoietic stem cells in the zebrafish embryo
Authors: Nardi G. , Torcq L. , Schmidt A. A. , Olivo-Marin J.-C. 
Published: November 2024

Abstract
We develop a novel method for image segmentation of 3D confocal microscopy images of emerging hematopoietic stem cells. The method is based on the theory of persistent homology and uses an optimal threshold to select the most persistent cycles in the persistence diagram. This enables the segmentation of the image’s most contrasted and representative shapes. Coupling this segmentation method with a meshing algorithm, we define a pipeline for 3D reconstruction of confocal volumes. Compared to related methods, this approach improves shape segmentation, is more ergonomic to automatize, and has fewer parameters. We apply it to the segmentation of membranes, at subcellular resolution, of cells involved in the endothelial-to-hematopoietic transition (EHT) in the zebrafish embryos.
Gender Matters: A Critical Piece in Mental Health
Authors: Baños Rosa María , Miragall Marta 
Published: November 2024

Abstract
Gender is a socially constructed concept influenced by social practices, norms, and expectations. The impact of gender differences on mental health has been long recognized, with consequences such as over-diagnosis and pathologization or under-diagnosis of some disorders depending on gender. This also has implications for the treatments that each gender receives. In this narrative review, we will analyze (a) the gender differences in the prevalence of mental disorders, (b) the explanations for gender differences in mental health, including biological, social constructionist, and sociocultural risk factors, and (c) the gender differences in the treatment of mental disorders, including differences in health-seeking behavior and treatment outcomes. Overall, there is a consistent pattern of differences in prevalence, with women more likely to have internalizing disorders (e.g., anxiety or depression) and men more likely to have externalizing disorders (e.g., antisocial personality or substance use). The explanations aimed at disentangling the reasons for these gender differences are complex, and several approaches should be considered to achieve a comprehensive explanation. In addition to biological factors (e.g., hormonal changes), social constructionist factors (e.g., biased diagnostic criteria and clinicians’ gender bias) and sociocultural factors (e.g., feminization of poverty, gender discrimination, violence against women, and prescriptive beauty standards) should be considered. Future studies in the field of mental health should consider gender differences and explore the bio-psycho-socio-cultural factors that may underlie these differences.
CuS-NiTe2 embedded phosphorus-doped graphene oxide catalyst for evaluating hydrogen evolution reaction
Authors: Parvaz Sedigheh , Talebi Vandishi Zahra , Ensafi Ali A. , Zarean Mousaabadi Kimia 
Published: November 2024

AbstractThe hydrogen evolution reaction (HER), a crucial half-reaction in the water-splitting process, is hindered by slow kinetics, necessitating efficient electrocatalysts to lower overpotential and enhance energy conversion efficiency. Transition-metal electrode materials, renowned for their robustness and effectiveness, have risen to prominence as primary contenders in the field of energy conversion and storage research. In this investigation, we delve into the capabilities of transition metals when employed as catalysts for the HER. Furthermore, we turn our attention to carbon nanomaterials like graphene, which have exhibited tremendous potential as top-performing electrocatalysts. Nevertheless, advancements are indispensable to expand their utility and versatility. One such enhancement involves the integration of phosphorus-doped graphene. Our research focuses on the synthesis of CuS–NiTe2/PrGO, a nanocomposite with a crystalline structure, through a straightforward method. This nanocomposite exhibits enhanced catalytic activity for the HER, boasting a Tafel slope of 57 mV dec−1 in an acidic environment. Consequently, our findings present a straightforward and efficient approach to developing high-performance electrocatalysts for HER.
Sex differences in the association between repetitive negative thinking and neurofilament light
Authors: Lau Yolanda , Bansal Amit , Palix Cassandre , Demnitz-King Harriet , Wirth Miranka , Klimecki Olga , Chetelat Gael , Poisnel Géraldine , Marchant Natalie L. ,   The Medit-Ageing Research Group, Chocat Anne , Collette Fabienne , De La Sayette Vincent , Delarue Marion , Espérou Hélène , Ferrand Devouge Eglantine , Frison Eric , Gonneaud Julie , Jessen Frank , Kaliman Perla , Kuhn Elizabeth , Lefranc Valérie , Lutz Antoine , Ourry Valentin , Quillard Anne , Salmon Eric , Smagghe Delphine , Smith Rhonda , Schlosser Marco , Touron Edelweiss , Wallet Cédric , Whitfield Tim 
Published: November 2024

Abstract
Emerging evidence suggests that repetitive negative thinking (RNT; i.e., worry and ruminative brooding) is associated with biomarkers of Alzheimer’s disease. Given that women have a greater risk of many neurodegenerative diseases, this study investigated whether worry and brooding are associated with general neurodegeneration and whether associations differ by sex. Exploratory analyses examined whether allostatic load, a marker of chronic stress, mediates any observed relationships. Baseline data from 134 cognitively healthy older adults in the Age-Well clinical trial were utilised. Worry and brooding were assessed using questionnaires. Plasma neurofilament light chain (NfL), a biomarker of neurodegeneration, was quantified using a Meso Scale Discovery assay. We found a positive interaction between brooding and sex on NfL, with higher brooding associated with greater NfL levels in women. No associations were observed between worry/ruminative brooding and allostatic load. These results offer preliminary support that RNT is associated with worse brain health, specifically in women.
Glutamylation imbalance impairs the molecular architecture of the photoreceptor cilium
Authors: Mercey Olivier , Gadadhar Sudarshan , Magiera Maria M , Lebrun Laura , Kostic Corinne , Moulin Alexandre , Arsenijevic Yvan , Janke Carsten , Guichard Paul , Hamel Virginie 
Published: November 2024

AbstractMicrotubules, composed of conserved α/β-tubulin dimers, undergo complex post-translational modifications (PTMs) that fine-tune their properties and interactions with other proteins. Cilia exhibit several tubulin PTMs, such as polyglutamylation, polyglycylation, detyrosination, and acetylation, with functions that are not fully understood. Mutations in AGBL5, which encodes the deglutamylating enzyme CCP5, have been linked to retinitis pigmentosa, suggesting that altered polyglutamylation may cause photoreceptor cell degeneration, though the underlying mechanisms are unclear. Using super-resolution ultrastructure expansion microscopy (U-ExM) in mouse and human photoreceptor cells, we observed that most tubulin PTMs accumulate at the connecting cilium that links outer and inner photoreceptor segments. Mouse models with increased glutamylation (Ccp5−/− and Ccp1−/−) or loss of tubulin acetylation (Atat1−/−) showed that aberrant glutamylation, but not acetylation loss, disrupts outer segment architecture. This disruption includes exacerbation of the connecting cilium, loss of the bulge region, and destabilization of the distal axoneme. Additionally, we found significant impairment in tubulin glycylation, as well as reduced levels of intraflagellar transport proteins and of retinitis pigmentosa-associated protein RPGR. Our findings indicate that proper glutamylation levels are crucial for maintaining the molecular architecture of the photoreceptor cilium.
METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma
Authors: Thombare Ketan , Vaid Roshan , Pucci Perla , Ihrmark Lundberg Kristina , Ayyalusamy Ritish , Baig Mohammad Hassan , Mendez Akram , Burgos-Panadero Rebeca , Höppner Stefanie , Bartenhagen Christoph , Sjövall Daniel , Rehan Aqsa Ali , Dattatraya Nale Sagar , Djos Anna , Martinsson Tommy , Jaako Pekka , Dong Jae-June , Kogner Per , Johnsen John Inge , Fischer Matthias , Turner Suzanne D , Mondal Tanmoy 
Published: November 2024

AbstractNeuroblastoma (NB) is the most common extracranial childhood cancer, caused by the improper differentiation of developing trunk neural crest cells (tNCC) in the sympathetic nervous system. The N6-methyladenosine (m6A) epitranscriptomic modification controls post-transcriptional gene expression but the mechanism by which the m6A methyltransferase complex METTL3/METTL14/WTAP is recruited to specific loci remains to be fully characterized. We explored whether the m6A epitranscriptome could fine-tune gene regulation in migrating/differentiating tNCC. We demonstrate that the m6A modification regulates the expression of HOX genes in tNCC, thereby contributing to their timely differentiation into sympathetic neurons. Furthermore, we show that posterior HOX genes are m6A modified in MYCN-amplified NB with reduced expression. In addition, we provide evidence that sustained overexpression of the MYCN oncogene in tNCC drives METTL3 recruitment to a specific subset of genes including posterior HOX genes creating an undifferentiated state. Moreover, METTL3 depletion/inhibition induces DNA damage and differentiation of MYCN overexpressing cells and increases vulnerability to chemotherapeutic drugs in MYCN-amplified patient-derived xenografts (PDX) in vivo, suggesting METTL3 inhibition could be a potential therapeutic approach for NB.
Auxiliaries in Old Dutch
Authors: Coussé Evie , Bouma Gerlof , van der Sijs Nicoline 
Published: November 2024

Abstract
This study explores the use of auxiliaries in the oldest text available for Old Dutch, the Wachtendonck Psalter,
dating from the 10th century. Our aim is to understand why there are so few different auxiliaries in this text in comparison to
other texts in Old Dutch. We tackle this question by taking a historical comparative perspective, using methodological insights
and techniques from corpus-based contrastive linguistics and typology. More specifically, we build a diachronic parallel corpus of
psalm translations and compare the contexts in which auxiliaries and inflectional alternatives are used in these parallel texts by
means of multidimensional scaling. Our historical comparative method results in five proximity maps which allow us to explore and
compare the inventory of verb constructions of the Wachtendonck Psalter both retrospectively, with its source text in Latin, and
prospectively, with later translations in Dutch. Our analysis examines the role of grammaticalization as well as the specific
nature of the text as an interlinear translation as possible motivations for the presence and absence of auxiliaries in the
Wachtendonck Psalter.