bluuebunny/crossref_metadata_2025_split huggingface dataset:
Planning antepartum directed donations in preparation for neonatal cardiac surgery in the absence of compatible donors
Authors: Bienz Marc , Constanzo‐Yanez Jessica , Baillargeon Nadia , Leiva‐Torres Gabriel André , Boileau Mélissa , Cloutier Marc , Laforce‐Lavoie Audrey , Robitaille Nancy 
Published: December 2024

AbstractBackgroundHomozygous inheritance of the RN haplotype, characterized by the absence of the high frequency antigen Sec, as well as partial C and e antigens, is rare and is associated with potential for alloimmunization. Anti‐Sec has been reported to be associated with a risk of delayed hemolytic transfusion reaction and hemolytic disease of the fetus and newborn (HDFN).ResultsWe report the case of a 36‐year‐old pregnant woman with known sickle cell trait (SCT) and homozygous for the RN haplotype with anti‐Sec, anti‐c, and anti‐e. Morphological ultrasound identified dextro‐transposition of the great arteries in the fetus. Neonatal cardiac surgery was planned with cardiopulmonary bypass support. Due to the rarity of this genotype, there were no compatible donors in our registry. For this reason, in addition to two previously glycerolized maternal donations, the mother donated three units during pregnancy and one unit postpartum.DiscussionThis case highlights the many complexities for the blood supplier pertaining to organizing blood donations during pregnancy, the risk of leukoreduction failure and jellification during the deglycerolization process of units from donors with rare blood carrying the SCT, as well as planning the rare‐blood inventory and managing expiry dates to provide transfusion support during delivery, neonatal surgery, and the postoperative period. This case also exemplifies the importance of a strong partnership between blood suppliers and medical teams.
Patient-level analysis of the cost and variation in melatonin prescribing patterns in those under 18 in the North East of England
Authors: McLellan Elizabeth Miriam , Haq Iram J , Ebdon Anne-Marie , Vasey Nicola , Anderson Kirstie N 
Published: December 2024

BackgroundMelatonin is widely used to promote sleep in both normally developing children and adolescents and those with neurodevelopmental disorders. It has an evidence base as both hypnotic and chronobiotic although the optimum dose and timing remain unclear. There are now a wide variety of different preparations of melatonin both immediate and prolonged release. We reviewed annual national and regional prescribing data and undertook a detailed review of one year of melatonin prescriptions issued to those under 18 within one of the UK’s dedicated paediatric hospitals, this included a cost analysis. This was to understand whether prescribing was appropriate, whether behavioural therapies had been recommended first and whether there had been consideration of other causes of poor sleep, such as sleep apnoea.MethodsBetween November 2020 and October 2021, 220 patients under 18 had one or more melatonin prescriptions issued to treat poor sleep. The audit assessed whether prescriptions were issued in accordance with local Melatonin Shared Care Guidance standards that emphasise: an initial behavioural approach, fixed timing, use of licensed preparations and review of benefit. This included a detailed review of electronic patient care records. A cost analysis of the different preparations was also made.Results adherence to the audit were not met for any of the audit standards, only 9% had a prior behavioural intervention, and only 15% had another sleep disorder considered. Community prescribers were more likely to give advice on timing and review any subsequent benefit. The total costs of prescriptions were £13 299 of which £8736 was issued as off licence, liquid suspension.ConclusionThe audit highlighted a lack of knowledge about appropriate melatonin prescribing and led to a trust-wide sleep education programme. It additionally highlighted the cost and potential risk of inappropriate prescribing and a clear need for better access to effective behavioural interventions.
Compressing Neural Networks Using Learnable 1-D Non-Linear Functions
Authors: Singh Gaurav , Bazargan Kia 
Published: December 2024

As deep learning models grow in size to achieve state-of-the-art accuracy, there is a pressing need for compact models. To address this challenge, we introduce a novel operation called Personal Self-Attention (PSA). It is specifically designed to learn non-linear 1-D functions, enhancing existing spline-based methods while remaining compatible with gradient backpropagation. By integrating these non-linear functions with linear transformations, we can achieve the accuracy of larger models but with significantly smaller hidden dimensions, which is crucial for FPGA implementations.
We evaluate PSA by implementing it in a Multi-Layer Perceptron (MLP)-based vision model, ResMLP, and testing it on the CIFAR-10 classification task. MLP is gaining increasing popularity due to its widespread use in large-language models. Our results confirm that PSA achieves equivalent accuracy with a 2x smaller hidden size compared to conventional MLPs. Furthermore, by quantizing our non-linear function into a simple lookup table, we reduce the number of operations required by 45%-28%, which offers significant benefits for hardware accelerators. To showcase this, we design an end-to-end unrolled streaming accelerator for ResMLP, demonstrating that our compressed model maintains an 88% accuracy while reducing LUT + DSP resource requirements by 25%, and doubling throughput to 32kFPS. Additionally, we implement a fixed-size SIMD accelerator for the same compressed model that achieves a 62.1% improvement in throughput while only consuming 3.5% extra LUTs.
Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions
Authors: Lamoureux Audrey-Anne , Fisher Michael J. , Lemelle Lauriane , Pfaff Elke , Amir-Yazdani Pouneh , Kramm Christof , De Wilde Bram , Kazanowska Bernarda , Hutter Caroline , Pfister Stefan M. , Sturm Dominik , Jones David T.W. , Orbach Daniel , Pierron Gaëlle , Raskin Scott , Drilon Alexander , Diamond Eli L. , Harada Guilherme , Zapotocky Michal , Zamecnik Josef , Krskova Lenka , Ellezam Benjamin , Weil Alexander G. , Venne Dominic , Barritault Marc , Leblond Pierre , Coltin Hallie , Hammad Rawan , Tabori Uri , Hawkins Cynthia , Hansford Jordan R. , Meyran Deborah , Erker Craig , McFadden Kathryn , Sato Mariko , Gottardo Nicholas G. , Dholaria Hetal , Nørøxe Dorte Schou , Goto Hiroaki , Ziegler David S. , Lin Frank Y. , Parsons Donald Williams , Lindsay Holly , Wong Tai-Tong , Liu Yen-Lin , Wu Kuo-Sheng , Franson Andrea T. , Hwang Eugene , Aguilar-Bonilla Ana , Cheng Sylvia , Cacciotti Chantel , Massimino Maura , Schiavello Elisabetta , Wood Paul , Hoffman Lindsey M. , Cappellano Andréa , Lassaletta Alvaro , Van Damme An , Llort Anna , Gerber Nicolas U. , Spalato Ceruso Mariella , Bendel Anne E. , Skrypek Maggie , Hamideh Dima , Mushtaq Naureen , Walter Andrew , Jabado Nada , Alsahlawi Aysha , Farmer Jean-Pierre , Coleman Christina , Mueller Sabine , Mazewski Claire , Aguilera Dolly , Robison Nathan J. , O’Halloran Katrina , Abbou Samuel , Berlanga Pablo , Geoerger Birgit , Øra Ingrid , Moertel Christopher L. , Razis Evangelia D. , Vernadou Anastasia , Ducray François , Bronnimann Charlotte , Seizeur Romuald , Clarke Matthew , Resnick Adam C. , Alves Mélanie , Jones Chris , Doz François , Laetsch Theodore W. , Perreault Sébastien 
Published: December 2024

Abstract

Purpose:
Tropomyosin receptor kinase (TRK) fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients.

Experimental Design:
We conducted an international retrospective cohort study of patients with TRK fusion–driven central nervous system tumors.

Results:
A total of 119 patients were identified. The median age at the time of diagnosis was 4.5 years. The majority were reported to have a histology consistent with a diagnosis of high-grade glioma (HGG; 57.1%) followed by low-grade glioma (LGG; 27.7%). Pediatric patients had a better prognosis, with a median overall survival of 185.5 months compared with 24.8 months in adults (P &lt; 0.0001). Patients with LGG also had a better outcome when compared with HGG (P = 0.0012). The objective response was 68.8% with larotrectinib compared with 38.1% for nontargeted treatment.

Conclusions:
Children with LGG had a favorable outcome compared with adult glioma and HGG. TRK inhibitors seem to improve tumor control.
Inhibition of PSF Activity Overcomes Resistance to Treatment in Cancers Harboring Mutant p53
Authors: Takayama Ken-ichi , Sato Tomohiro , Honma Teruki , Yoshida Minoru , Inoue Satoshi 
Published: December 2024

Abstract
Mutations in the TP53 tumor suppressor genes are prevalent in aggressive cancers. Pharmacologic reactivation of dysfunctional p53 due to mutations is a promising strategy for treating such cancers. Recently, a multifunctional proline- and glutamine-rich protein, polypyrimidine tract–binding protein–associated splicing factor (PSF), was identified as a key driver of aggressive cancers. PSF promotes the expression of numerous oncogenes by modulating epigenetic and splicing mechanisms. We previously screened a small-molecule library and discovered compound No. 10-3 as a potent PSF inhibitor. Here, we report the discovery of a No. 10-3 analog, 7,8-dimethoxy-4-(4-methoxy-phenyl)-chromen-2-one (C-30), as a potent PSF inhibitor. Compared with No. 10-3, C-30 treatment specifically suppressed the growth and induced apoptosis of mutant p53-bearing and therapy-resistant cancer cells. Interestingly, C-30 activated a set of p53-regulated genes in therapy-resistant cancer cells. A comprehensive analysis of PSF and p53-binding regions demonstrated a higher level of PSF-binding potential in mutant p53-expressing cancer cells around genomic regions identified as p53-binding peaks in p53 wild-type cancer cells. Treatment of mutant p53-expressing cancer cells with C-30 decreases PSF binding around these sites, leading to activated histone acetylation. We further demonstrated that C-30 impaired tumor growth and increased the expression of p53 target genes in vivo. These results suggested that C-30 produces tumor-suppressive effects similar to the functional reactivation of p53, providing a rationale for the inhibition of PSF activity as a promising therapy against treatment-resistant cancer.
Efficacy of CBP/p300 Dual Inhibitors against Derepression of KREMEN2 in cBAF-Deficient Cancers
Authors: Sasaki Mariko , Kato Daiki , Yoshida Hiroshi , Shimizu Takafumi , Ogiwara Hideaki 
Published: December 2024

Abstract
The SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex is divided into three subcomplexes: cBAF, PBAF, and ncBAF. Constituent genes (e.g., SMARCB1, SMARCA4, SMARCA2, and SS18) of the SWI/SNF complex often harbor genetic abnormalities in various cancers. Previously, we found that histone acetyltransferases CBP/p300 dual inhibitors could be promising treatments for SMARCB1-deficient cancers. We show that treatment with CBP/p300 dual inhibitors causes synthetic lethality in cBAF-deficient cancers such as SMARCA4/SMARCA2-deficient and SS18–SSX fusion cancers. Given the sensitivity to CBP/p300 dual inhibitors and their commonality with SWI/SNF subcomplexes containing each subunit, CBP/p300 dual inhibitors could be promising treatments for cancers harboring abnormalities in constituent genes included in the entire cBAF subcomplex. Because SMARCA4/SMARCA2-deficient and SS18–SSX fusion cancer cells depend on transcriptional upregulation of KREMEN2 due to SMARCA4/SMARCA2 deficiency and SS18–SSX fusion, we clarified that synthetic lethality is induced by repressing expression of KREMEN2 by simultaneous inhibition of CBP/p300. In addition, simultaneous inhibition of CBP/p300 led to transcriptional downregulation of KREMEN2, followed by apoptosis induction via KREMEN1. Furthermore, treatment with CBP/p300 dual inhibitor suppressed the growth of xenografts derived from SMARCA4/SMARCA2-deficient and SS18–SSX fusion cancer cells, resulting from repression of KREMEN2 and induction of apoptosis. Thus, CBP/p300 dual inhibitors could be promising for SMARCA4/SMARCA2-deficient lung cancer and SS18–SSX fusion synovial sarcoma, which are entirely deficient in the cBAF complex.

Significance:
In this study, we clarified that the cBAF subcomplex is deficient in the SWI/SNF complex, resulting in dependency on the CBP/p300 paralog pair. Simultaneous inhibitors of the CBP/p300 paralog pair show promise for cBAF-deficient lung cancer, as well as rare cancers such as malignant rhabdoid tumors, epithelioid sarcomas, and synovial sarcomas.
Artificial Intelligence–Based Feature Analysis of Pulmonary Vein Morphology on Computed Tomography Scans and Risk of Atrial Fibrillation Recurrence After Catheter Ablation: A Multi-Site Study
Authors: Asaeikheybari Golnoush , El-Harasis Majd , Gupta Amit , Shoemaker M. Benjamin , Barnard John , Hunter Joshua , Passman Rod S. , Sun Han , Kim Hyun Su , Schilling Taylor , Telfer William , Eldridge Britta , Chen Po-Hao , Midya Abhishek , Varghese Bibin , Harwood Samuel J. , Jin Alison , Wass Sojin Y. , Izda Aleksandar , Park Kevin , Abraham Abel , Van Wagoner David R. , Tandon Animesh , Chung Mina K. , Madabhushi Anant 
Published: December 2024

BACKGROUND:
Atrial fibrillation (AF) recurrence is common after catheter ablation. Pulmonary vein (PV) isolation is the cornerstone of AF ablation, but PV remodeling has been associated with the risk of AF recurrence. We aimed to evaluate whether artificial intelligence–based morphological features of primary and secondary PV branches on computed tomography images are associated with AF recurrence post-ablation.

METHODS:

Two artificial intelligence models were trained for the segmentation of computed tomography images, enabling the isolation of PV branches. Patients from Cleveland Clinic (N=135) and Vanderbilt University (N=594) were combined and divided into 2 sets for training and cross-validation (D
1
, n=218) and internal testing (D
2
, n=511). An independent validation set (D
3
, N=80) was obtained from University Hospitals of Cleveland. We extracted 48 fractal-based and 12 shape-based radiomic features from primary and secondary PV branches of patients with AF recurrence (AF+) and without recurrence after catheter ablation of AF (AF-). To predict AFrecurrence, 3 Gradient Boosting classification models based on significant features from primary (M

p

), secondary (M

s

), and combined (M

c

) PV branches were built.

RESULTS:

Features relating to primary PVs were found to be associated with AF recurrence. The M

p

classifier achieved area under the curve values of 0.73, 0.71, and 0.70 across the 3 datasets. AF+ cases exhibited greater surface complexity in their primary PV area, as evidenced by higher fractal dimension values compared with AF- cases. The M

s

classifier results revealed a weaker association with AF+, suggesting higher relevance to AF recurrence post-ablation from primary PV branch morphology.

CONCLUSIONS:
This largest multi-institutional study to date revealed associations between artificial intelligence–extracted morphological features of the primary PV branches with AF recurrence in 809 patients from 3 sites. Future work will focus on enhancing the predictive ability of the classifier by integrating clinical, structural, and morphological features, including left atrial appendage and left atrium–related characteristics.
Direct segmentation of cortical cytoarchitectonic domains using ultra-high-resolution whole-brain diffusion MRI
Authors: Pas Kristofor E. , Saleem Kadharbatcha S. , Basser Peter J. , Avram Alexandru V. 
Published: December 2024

Abstract
We assess the potential of detecting cortical laminar patterns and areal borders by directly clustering voxel values of microstructural parameters derived from high-resolution mean apparent propagator (MAP) magnetic resonance imaging (MRI), as an alternative to conventional template-warping-based cortical parcellation methods. We acquired MAP-MRI data with 200 μm resolution in a fixed macaque monkey brain. To improve the sensitivity to cortical layers, we processed the data with a local anisotropic Gaussian filter determined voxel-wise by the plane tangent to the cortical surface. We directly clustered all cortical voxels using only the MAP-derived microstructural imaging biomarkers, with no information regarding their relative spatial location or dominant diffusion orientations. MAP-based 3D cytoarchitectonic segmentation revealed laminar patterns similar to those observed in the corresponding histological images. Moreover, transition regions between these laminar patterns agreed more accurately with histology than the borders between cortical areas estimated using conventional atlas/template-warping cortical parcellation. By cross-tabulating all cortical labels in the atlas- and MAP-based segmentations, we automatically matched the corresponding MAP-derived clusters (i.e., cytoarchitectonic domains) across the left and right hemispheres. Our results demonstrate that high-resolution MAP-MRI biomarkers can effectively delineate three-dimensional cortical cytoarchitectonic domains in single individuals. Their intrinsic tissue microstructural contrasts enable the construction of whole-brain mesoscopic cortical atlases.
Brain-wide functional connectome analysis of 40,000 individuals reveals brain networks that show aging effects in older adults
Authors: Pan Yezhi , Bi Chuan , Kochunov Peter , Shardell Michelle , Smith J. Carson , McCoy Rozalina G. , Ye Zhenyao , Yu Jiaao , Lu Tong , Yang Yifan , Lee Hwiyoung , Liu Song , Gao Si , Ma Yizhou , Li Yiran , Chen Chixiang , Ma Tianzhou , Wang Ze , Nichols Thomas , Hong L. Elliot , Chen Shuo 
Published: December 2024

Abstract
The functional connectome changes with aging. We systematically evaluated aging-related alterations in the functional connectome using a whole-brain connectome network analysis in 39,675 participants in UK Biobank project. We used adaptive dense network discovery tools to identify networks directly associated with aging from resting-state functional magnetic resonance imaging (fMRI) data. We replicated our findings in 499 participants from the Lifespan Human Connectome Project in Aging study. The results consistently revealed two motor-related subnetworks (both with permutation test p-values &lt;0.001) that showed a decline in resting-state functional connectivity (rsFC) with increasing age. The first network primarily comprises sensorimotor and dorsal/ventral attention regions from precentral gyrus, postcentral gyrus, superior temporal gyrus, and insular gyrus, while the second network is exclusively composed of basal ganglia regions, namely the caudate, putamen, and globus pallidus. Path analysis indicates that white matter fractional anisotropy mediates 19.6% (p &lt; 0.001, 95% CI [7.6% 36.0%]) and 11.5% (p &lt; 0.001, 95% CI [6.3% 17.0%]) of the age-related decrease in both networks, respectively. The total volume of white matter hyperintensity mediates 32.1% (p &lt; 0.001, 95% CI [16.8% 53.0%]) of the aging-related effect on rsFC in the first subnetwork.
Collection of dna and the Creation of dna Databases in India: A Proportionality Analysis on Whether There is a Violation of Genetic Privacy
Authors: Chandran Rudra 
Published: December 2024

Abstract
Genetic information, which can be processed from human bodily samples, contains three major types of information: first, individual traits such as the skin colour, race, eye colour, and height of the data subject; second, medical information such as information about genetic diseases and genetic predispositions; and third and most importantly, it can provide information about a class of persons who are genetically related to the data subject. Genetic data has huge application potential, from criminal investigations to assisted reproductive techniques. Thus, it is the most sensitive form of personal data. The concept of privacy in India has also evolved by way of judicial pronouncements and, in the case of K.S. Puttaswamy v Union of India, it was recognised as a fundamental right. The Indian Government has passed the Criminal Procedure Identification Act, 2022, which allows for the collection of measurements – including genetic samples – and authorises the National Crime Records Bureau to collect, store, process, share, and disseminate such data. In light of the above developments, this article analyses the constitutionality of section 3 of the Criminal Procedure Identification Act, 2022 through the lens of the principle of proportionality.
Male Rape Victims and the Case for a Gender-Neutral Definition of Rape in Bangladesh
Authors: Rahman Arifur 
Published: December 2024

Abstract
Rape laws in Bangladesh tend to operate on the putative gender binary and understand rape through the prism of penile-vaginal penetration. The idea of male rape, especially adult male rape, remains foreign to the existing rape laws, which leads to the underreporting of rape cases against men. This article argues for a gender-neutral definition of rape in Bangladesh. The justification is premised on two key arguments. First, it demonstrates that, like any other form of sexual and gender-based violence, male rape is a gendered crime. Second, both male rape and the absence of its legal recognition cut across an array of human rights of male rape victims in Bangladesh. The article concludes that a gender-neutral definition of rape would not only recognise the gendered harm that male rape survivors experience but also help Bangladesh fulfil its human rights obligations towards male rape survivors.
Mixed Messages: Reflections on Multiethnic Identity and Narratives in Youth Ministry Pedagogy
Authors: Mayward Joel 
Published: December 2024

Abstract
Drawing upon the work of Gloria E. Anzaldúa and Paul Ricoeur, this article presents a personal and scholarly reflection on the author’s multiethnic identity and how such identities may benefit youth ministry pedagogies and perspectives. The author explains Anzaldúa’s notion of nepantla alongside Ricoeur’s concepts of “narrative identity” and “social imaginary,” then demonstrates how these two thinkers’ perspectives can be interwoven and applied by educators and youth ministry practitioners. Ultimately, in sharing about his “mixed” heritage, the author contends that multiethnic individuals can serve as bridge-builders between cultures and generations.
Sovereignty and Oil
Authors: Stoekl Allan 
Published: December 2024

Abstract
This essay considers the question of sovereignty in relation to oil. First, in the conventional geo-strategic sense: control over oil resources is the sovereign right of a nation. But here national sovereignties conflict with each other, and sovereignty, supposedly absolute (it is by definition the unconditioned) turns out to be malleable, always qualified. Another, second sense involves sovereignty as the general will; here I propose that oil, and energy resources, have their own will, which enters into conflict with what is normally the general will of the people. Finally, a third sovereignty involves the radically unconditioned, in which energy is expended unconditionally, with no goal in sight or possible; this is the sovereignty of the sacred, or of erotism, and is the most basic aspect of energic ‘use.’