bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of a PET scan in selecting the best lymph node to biopsy, and confirming the diagnosis of idiopathic multicentric Castleman disease with HLH and EBV viremia in a previously healthy adult
Authors: Bitektine Erica , Hagh-Daoust Hamila , Michel René P. , Isnard Stephane , Routy Jean-Pierre 
Published: November 2024

Introduction: Castleman disease (CD) is a rare lymphoproliferative disorder having a variegated clinical presentation. Diagnosis of the idiopathic HIV- and HHV8-negative multicentric CD (iMCD) subtype poses a challenge given its non-specific clinical manifestations. iMCD presents as diffuse lymphadenopathy with inflammatory manifestations, primarily driven by interleukin-6 (IL-6). Treatment includes suppressing the inflammation by targeting IL-6 with monoclonal antibodies such as siltuximab and, in severe cases, immuno-chemotherapy to control B- and plasma-cell activation. Case description: A previously healthy 43-year-old male presented to the emergency department with fever, night sweats, anasarca, anaemia, thrombocytopenia and acute renal insufficiency. Extensive blood and imaging workup was initiated. Several diagnoses were entertained including viral infections (comprising COVID-19), haemophagocytic lymphohistiocytosis, lymphoma and autoimmune conditions. Initial axillary lymph node biopsy was not diagnostics. A positron emission tomography (PET) scan showed diffuse and symmetrical cervical and hilar/mediastinal lymphadenopathies. A mediastinal lymph node biopsy was then performed and indicated iMCD. The patient was treated with high-dose steroids and siltuximab. An Epstein-Barr virus (EBV) PCR was positive, and rituximab was added to the treatment. The patient recovered and felt well after two months. Conclusions: Non-specific symptoms, non-diagnostic first biopsy and iMCD resemblance to haemophagocytic lymphohistiocytosis further complicated the diagnosis. A PET scan allowed the best selection of a lymph node to be biopsied. Anti-IL6 is the recommended treatment; however, we are lacking information on the duration of siltuximab, and the long-term toxicity and immunosuppressive effect of this treatment. The contribution of EBV reactivation in the development and treatment of iMCD needs further investigation.
Practice patterns among ophthalmic surgeons in treating concomitant oculoplastic conditions in preoperative period: A questionnaire-based study
Authors: Panda Bijnya Birajita , Mishra Chitaranjan , Nayak Bhagabat , Roy Avik Kumar , Balakrishnan Logesh , Mishra Priyadarshini 
Published: November 2024

BACKGROUND
Addressing oculoplastic conditions in the preoperative period ensures both the safety and functional success of any ophthalmic procedure. Some oculoplastic conditions, like nasolacrimal duct obstruction, have been extensively studied, whereas others, like eyelid malposition and thyroid eye disease, have received minimal or no research.
AIM
To investigate the current practice patterns among ophthalmologists while treating concomitant oculoplastic conditions before any subspecialty ophthalmic intervention.
METHODS
A cross-sectional survey was disseminated among ophthalmologists all over India. The survey included questions related to pre-operative evaluation, anaesthetic and surgical techniques preferred, post-operative care, the use of adjunctive therapies, and patient follow-up patterns.
RESULTS
A total of 180 ophthalmologists responded to the survey. Most practitioners (89%) felt that the ROPLAS test was sufficient during pre-operative evaluation before any subspecialty surgery was advised. The most common surgical techniques employed were lacrimal drainage procedures (Dacryocystorhinostomy) (63.3%), eyelid malposition repair (36.9%), and ptosis repair (58.7%). Post-operatively, 47.7 % of respondents emphasized that at least a 4-week gap should be maintained after lacrimal drainage procedures and eyelid surgeries. Sixty-seven percent of ophthalmologists felt that topical anaesthetic procedures should be preferred while performing ocular surgeries in thyroid eye disease patients.
CONCLUSION
Approximately 50% of ophthalmologists handle prevalent oculoplastic issues themselves, seeking the expertise of an oculoplastic surgeon under particular conditions. Many ophthalmologists still favor using ROPLAS as a preliminary screening method before proceeding with cataract surgery. Eyelid conditions and thyroid eye disease are not as commonly addressed before subspecialty procedures compared to issues like nasolacrimal duct obstruction and periocular infections.
Evaluation of changes in fixed flexion deformity following medial unicompartmental knee arthroplasty
Authors: Wignadasan Warran , Magan Ahmed , Kayani Babar , Fontalis Andreas , Chambers Alastair , Rajput Vishal , Haddad Fares S. 
Published: November 2024

AimsWhile residual fixed flexion deformity (FFD) in unicompartmental knee arthroplasty (UKA) has been associated with worse functional outcomes, limited evidence exists regarding FFD changes. The objective of this study was to quantify FFD changes in patients with medial unicompartmental knee arthritis undergoing UKA, and investigate any correlation with clinical outcomes.MethodsThis study included 136 patients undergoing robotic arm-assisted medial UKA between January 2018 and December 2022. The study included 75 males (55.1%) and 61 (44.9%) females, with a mean age of 67.1 years (45 to 90). Patients were divided into three study groups based on the degree of preoperative FFD: ≤ 5°, 5° to ≤ 10°, and > 10°. Intraoperative optical motion capture technology was used to assess pre- and postoperative FFD. Clinical FFD was measured pre- and postoperatively at six weeks and one year following surgery. Preoperative and one-year postoperative Oxford Knee Scores (OKS) were collected.ResultsOverall, the median preoperative navigated (NAV) FFD measured 6.0° (IQR 3.1 to 8), while the median postoperative NAV FFD was 3.0° (IQR 1° to 4.4°), representing a mean correction of 49.2%. The median preoperative clinical FFD was 5° (IQR 0° to 9.75°) for the entire cohort, which decreased to 3.0° (IQR 0° to 5°) and 2° (IQR 0° to 3°) at six weeks and one year postoperatively, respectively. A statistically significant improvement in PROMs compared with baseline was evident in all groups (p < 0.001). Regression analyses showed that participants who experienced a larger FFD correction, showed greater improvement in PROMs (β = 0.609, p = 0.049; 95% CI 0.002 to 1.216).ConclusionThis study found that UKA was associated with an approximately 50% improvement in preoperative FFD across all three examined groups. Participants with greater correction of FFD also demonstrated larger OKS gains. These findings could prove a useful augment to clinical decision-making regarding candidacy for UKA and anticipated improvements in FFD.
Indigenous Feminism in Environmental Sustainability: Zora Neale Hurston’s Dust Tracks on A Road (1942)
Authors: Sadiq Aisha 
Published: November 2024

Abstract
In this essay, I explore and analyze Zora Neale Hurston’s autoethnography The Dust Tracks on a Road (1942) as an alternative to the modern anthropological simplification of nature and the African American indigenous identity. Hurston’s indigenous feminist subjectivity is focused on environmental sustainability and her resistance to anthropocentrism and racialized labor. Hurston’s subjectivity as an indigenous feminist scholar can be articulated as minoritarian in the critical posthumanities since it is not about margin; rather, it revolutionizes anthropological discourse by re-signifying the African American lumberer identity and environmental sustainability in a robust, appealing, and unique manner. She reconceptualizes Black indigenous lumberers by articulating their historical and cultural relationality with the forests owned by forest industries in Polk County, Florida.
Distant-Reading Communities: Monolingualisation in Fin-de-Siècle European Literary Historiography
Authors: Millim Anne-Marie 
Published: November 2024

Abstract
A return to earlier forms of distant reading multilingual corpora allows us to reflect on the monolingual authorial position that manages and mediates the language diversity and linguistic specificity (literariness) of multilingual corpora with the objective of fostering supranational (imagined) communities of readers (Anderson, 1983). Revisiting the distant-reading practices of fin-de-siècle Britain can help us identify historiographical focal points and priorities, provide an understanding of the scope and circumference of the corpus, and reveal the conceptions of gain and loss perceived as integral to distant reading. The tension between enrichment and dispossession inherent in the practice of literary historiography is acute when it comes to multilingual corpora, compiled to facilitate a crossing and re-weaving of the boundaries of language, understanding, and community. In the 12-volume series Periods of European Literature, edited and, in part, written by the journalist, literary historian, and Chair of Rhetoric and English Literature at Edinburgh University, George Saintsbury (1845–1933), Anglophone comparatists represent the multilingual corpora of exemplar works, gauging the necessity for, or dispensability of, translation, and managing the “great unread”, which, in this case, equates the “great unreadable”. In their desire to build imagined communities of readers of European literature, Saintsbury and his contributors tend to operate in a monolingual supralinguistic sphere in which languages, authors, and works are named, passages are occasionally quoted, but in which no reading of literature, neither on the side of the comparatist, nor of the reader, takes place. Literary language is thus only tangentially part of literary historiography.
Art, Magic and the Corruption of Consciousness
Authors: Connelly James 
Published: November 2024

Abstract
The purpose of this paper is to provide a brief account of part of Collingwood’s philosophy of art, in particular that dealing with the relationship between art, craft and magic, in relation to the corruption of consciousness, and to consider some of the implications for the aesthetic evaluation of ‘works of art’ produced as moral or political propaganda. I shall try to do this by drawing on the work of Matthew Kieran in relation to art and morality. I will not so much analyse or criticise Collingwood’s conception of the corruption of consciousness as presuppose it as the conception which makes sense of Collingwood’s understanding of the relation between art and morality.
Histological transformation in lung adenocarcinoma: Insights of mechanisms and therapeutic windows
Authors: Tan Nuopei , Li Yan , Ying Jianming , Chen Wanqing 
Published: November 2024

Abstract
Histological transformation from lung adenocarcinoma (ADC) to small cell lung carcinoma (SCLC), large cell neuroendocrine carcinoma (LCNEC), squamous cell carcinoma (SCC), and sarcomatoid carcinoma (PSC) after targeted therapies is recognized as a mechanism of resistance in ADC treatments. Patients with transformed lung cancer typically experience a poor prognosis and short survival time. However, effective treatment options for these patients are currently lacking. Therefore, understanding the mechanisms underlying histological transformation is crucial for the development of effective therapies. Hypotheses including intra-tumoral heterogeneity, cancer stem cells, and alteration of suppressor genes have been proposed to explain the mechanism of histological transformation. In this review, we provide a comprehensive overview of the known molecular features and signaling pathways of transformed tumors, and summarized potential therapies based on previous findings.
Analysis of hypothetical channel flow blockage of a tubular fuel assembly in a 10 MWth nuclear research reactor
Authors: Ibrahim Said M. A. , Esawy Mohamed H. , Yousif Hossam I. 
Published: November 2024

Abstract
Heat removal from the core of nuclear reactors is a crucial safety requirement that needs much analysis and attention. Coolant channel flow blockage is one of the unintentional cases that may influence the required heat removal rate. As a result, unsustainable over heating of the fuel cladding could occur resulting eventually in affecting the fuel integrity. This paper deals with simulating the effect of total channel flow blockage in a single fuel assembly on its steady state thermal hydraulic parameters. Thermal hydraulic calculations are carried out for the much less studied IRT-4M ducted fuel assembly type in a 10 MWth WWR-S tank in pool research reactor. The simulated IRT-4M fuel assembly comprises six rounded rectangular fuel elements in which seven channels are used for cooling. A mathematical model is developed in which all steady state thermal hydraulic parameters and their distributions could be predicted for the blocked and unblocked flow channel cases. Calculations were performed for two separate hypothetical flow channel blockage cases in the innermost channel and the middle channel of the IRT-4M fuel assembly. The results showed that the maximum clad temperatures for the two-flow blockage cases are nearly 127.4 °C, and 132.2 °C, respectively. The temperature increases resulting from a single channel blockage are not high enough to cause fuel damage, although some local coolant boiling might occur. Model validation and results support the model outcomes and its applications in the safety of the research reactor during abnormal operation.
Improved intelligent model predictive controller for the nuclear power reactor system
Authors: Mostafa Khaled M. , AbduAllah Mahmoud , Saleh Hassan , Elsawy Nabila 
Published: November 2024

Abstract
Over the last two decades, extensive research has been conducted to enhance the control performance of reactor power. Various methodologies have been suggested and implemented to achieve optimal power control in nuclear reactors. However, due to the diverse characteristics and inherent uncertainties in the models, devising optimal controllers for nuclear systems remains a complex task. To address this, numerous approaches have been adopted to ensure controllability and resilience, aiming for an optimal nuclear power reactor controller. The Model Predictive Control (MPC) algorithm has garnered significant attention as a viable approach to boost operational efficiency and overall system utility. In this research, Particle Swarm Optimization (PSO) method and MPC controller are combined together to form a novel algorithm termed PSO-MPC, aiming to amplify the system’s performance and overcomes the local minima problem that basically happens when using MPC controller. First, MPC controller is applied to the nuclear reactor model, then the suggested technique PSO-MPC also is applied to the system and a comparison of the outcomes using both techniques is done. The results demonstrate enhanced system response using the innovative technique.
Evaluation of cultivation technology package and corn variety based on agronomy characters and leaf green indices
Authors: Musa Yunus , Farid Muh , Iswoyo Hari , Adzima Achmad Fauzan , Anshori Muhammad Fuad , Arief Ramlah 
Published: November 2024

Abstract
This study aimed to identify the best combination of corn technologies and varieties to increase yield, a study case in Torowang, South Sulawesi. The findings of this study used a split-plot design with three replications. The cultivation technology package is composed of planting spacing, chemical fertilizer, and biofertilizer, with three levels of treatment. Meanwhile, varieties treatment as subplot consisted of six varieties of treatment: Nasa 29, Bisi 18, Sinhas 1, NK7328, Pioneer 27, and ADV 313. The study determined the effectiveness of six agronomy and three chlorophyll pigment characters. Based on the results, varietal diversity dominates the differences in growth traits, both morphological and physiological. Varietal potential differs from the diversity of crop technology packages, which show no significant effect on all growth traits. However, the interaction between the growth package and varieties shows a significant effect, indicating that the crop technology package significantly affects the growth response. Yield was significantly correlated with plant height, 1,000 grain weight, peeled ear weight, chlorophyll content meter (CCM) chlorophyll, and NDVI-UAV. The total chlorophyll trait based on CCM showed a significant correlation with yield but did not correlate with NDVI-UAV. The study concluded that Pioneer 27 and ADV 313 varieties are recommended for cultivation in Takalar, with the combination of planting space of 75 × 20 cm + N:P:K fertilizer dose of 200:100:50 kg ha−1 + 25 kg of KNO3 + 5 cc L−1 of Eco-Farming fertilizer to Pioneer 27 (Pc2V5) recommended. Further dissemination is required in other regions.
»Glauben Sie mir […]: das Wort Zufall ist Gotteslästerung«
Authors: Dörr Volker C. 
Published: November 2024

Abstract
The essay begins with a discussion of the concepts of chance and contingency from both philosophical and common knowledge perspectives. Subsequently, the essay analyzes Schiller’s rejection of chance as a dramaturgical factor, which he offers in the preface to Die Verschwörung des Fiesko zu Genua. This analysis is conducted with a reference to Lessing’s Hamburgische Dramaturgie. The reading then poses the question: Could Schiller’s figure Fiesko and Lessing’s Orsina be correct in crediting Providence’s hand, despite their misguided perception of their own standing and role? After a brief exploration of the »Schicksalsdrama« genre, which was prominent in the 19th century, the focus then shifts to Friedrich Dürrenmatt’s comedy Die Physiker. In Dürrenmatt’s play, chance emerges as the ultimate principle governing worldly events.
Chengba: the Dangqu City of the Han Dynasty in south-west China
Authors: Sun Tianqiang , Liu Fang , Chen Weidong , Li Yingfu , Li Yuniu 
Published: November 2024

Abstract
The Chengba site is the only city site dated from the late Warring States Period in eastern Sichuan Province, China. New discoveries of artefacts and structures at the site enable exploration of the regional role and management of counties that were established at this time by the central government.
Focus on Executive Functions. Part 2: Nonverbal and Verbal Working Memory
Authors: Barkley Russell A. , Benton Christine M. 
Published: November 2024

The second in a 3-part series on executive functions. This series for adults with ADHD discusses the 7 executive functions that foster self-control—the abilities we use to monitor our own behavior to attain our goals. —Excerpted from Taking Charge of Adult ADHD (2nd ed.), by Russell A. Barkley with Christine M. Benton. Part 1: Self-awareness (the mind's mirror) and inhibition (the mind's brakes). Part 2: Nonverbal and verbal working memory (the mind’s eye and the mind’s voice). Part 3: Emotion regulation (the mind’s heart), self-motivation (the mind’s fuel tank), and planning/problem-solving (the mind’s playground).
Construction of CRISPR/Cas9 vector for editing <i>IaVQ9</i> gene in <i>Ipomoea aquatica</i>
Authors: Hue Huynh Thi Thu , Ngoc Nguyen Thi Bich , Thanh Le Tat , Hoa Nguyen Thi , Tri Le Minh , Thuy Le Thi Bich 
Published: November 2024

The group of proteins containing the VQ motif (named VQ proteins) is a family of plant-specific proteins with a FxxhVQxhTG conservative VQ-motif region. VQ proteins regulate many developmental processes, including responses to biotic and abiotic stresses, and seed development. The VQ9 protein has an interaction with the WRKY8 factor, when this interaction occurs, it causes a decrease in the DNA binding ability of WRKY8 to DNA, which plays a role in the regulation function of the plant to stress. Some mutations in the VQ9 gene increase salt tolerance in plants, suggesting that VQ9 acts antagonistically to regulate responses to salt conditions. This antagonism is consistent with an increase or decrease in the Na+/K+ ratio. Ipomoea aquatica is commonly grown and used as a vegetable in Southeast Asia. The research involved RNA extraction from I. aquatica leaves, followed by PCR sequencing to confirm the presence of the IaVQ9 gene. Subsequently, a specific guide RNA (gRNA) was designed using CRISPR-P ver.2.0 and inserted into the pRGEB31 vector, optimized for CRISPR/Cas9 applications. The gRNA-inserted vector was successfully transformed into E. coli DH10B and then into Agrobacterium tumefaciens EHA105, verified through colony PCR and restriction enzyme analysis. This process created a delivery system capable of editing the VQ9 gene in I. aquatica. This research represents a significant step towards improving crop resilience to salinity, addressing a critical challenge for agriculture in salt-affected regions. Future studies will focus on transferring the construct back into I. aquatica plants to assess its impact on enhancing salt tolerance, potentially contributing to sustainable crop production in adverse environmental conditions.
Inductive and Deductive Reasoning in Byrom vs. Johns Hopkins Bayview Hospital
Authors: Howard Smith 
Published: November 2024

The status quo that results from medical malpractice litigation is 85,000 medical malpractice lawsuits filed per year, of which 66% are potentially frivolous. There are also 3 million claims but only 85,000 are represented. There is something wrong with this status quo, which prompts questions about traditional decision-making Traditional decision-making is inductive reasoning. Deductive reasoning is hypothesis testing. The objective evidence and the burden of proof are the same in both; except hypothesis testing has a greater level of confidence. The differences are examined in detail. Of the parties involved in dispute resolution, medical experts are essential, medical experts are doctors. Doctors are familiar with hypothesis testing and threats to validity. Doctors, who are medical experts, are duty-bound to be objective. Hypothesis testing best satisfies this duty. Nothing prohibits medical experts from using hypothesis testing when they review a case to arrive at an opinion; although, until now, none do. Yet, as doctors, it is expected of them and they can never be prohibited from doing so. In the final analysis, traditional decision-making subjectively infers a departure from the standard of care; however, hypothesis testing objectively proves it.