bluuebunny/crossref_metadata_2025_split huggingface dataset:
Invasive hemodynamic monitoring during cardiopulmonary resuscitation in a community hospital emergency department
Authors: Duvoisin Robert M. , Broniak Frederick F. , Collop John R. , Collins Brian Christopher 
Published: February 2019

Abstract
Monitoring the effects of resuscitation efforts in a community emergency department are limited primarily to noninvasive techniques. Coronary perfusion pressure (CCP) has been used as a predictor for successful resuscitation. The authors investigated the feasibility of measuring the CPP in a community emergency department and incorporating the CPP into decisions for managing the resuscitation effort. During a 7-month period, the authors prospectively studied 77 nontraumatic, normothermic adults in cardiopulmonary arrest who were treated in the emergency department. Fifty-one patients underwent invasive monitoring and 26 patients entered a control (noninvasive monitoring) group. Successful CPP monitoring was accomplished in 84% of the patients; the average time to obtain an initial CPP was 12.1 ± 7.3 minutes. Twenty patients had a return of spontaneous circulation, but no patient survived to hospital discharge. There was no significant difference in return of spontaneous circulation between patients in the invasively monitored and the noninvasively monitored group. Coronary perfusion pressure monitoring had a positive influence on the management of three patients. This study showed that CPP monitoring is feasible in a community hospital, but further studies are needed to better define the effects of CPP in resuscitation effort outcome.
Familial glomerular disease with asymptomatic Proteinuria and nephrotic syndrome: a new clinical entity
Authors: Slick Gary L. , Mathis Beverly J. , Calabrese Kenneth E. 
Published: February 2019

Abstract
Seventy-three members of a 100-member kindred with asymptomatic proteinuria, nephrotic syndrome, and progressive renal failure were studied. Of those studied, 11 members had progressed to end-stage renal disease and seven had significant proteinuria (> 1 g/24 hours) with normal renal function. The genetic mode of inheritance was autosomal dominant with variable penetrance and expressivity. Histopathologic changes were variable but included focal segmental glomerulosclerosis and diffuse glomerulosclerosis. Renal failure usually occurred in the fifth decade of life. The most consistent clinical finding was proteinuria without microscopic hematuria or other significant urinary sediment elements. This disease differed from Alport's hereditary nephritis and congenital nephrotic syndrome in age of onset, urinary findings, and associated conditions, that is, nerve deafness. The hereditary proteinuria and nephrotic syndrome described in this kindred represents another facet in the spectrum of hereditary renal disease.
Therapeutic drug monitoring: Lithium levels
Authors: Fernandes John J. , Coffman Norman B. 
Published: February 2019

Abstract
Lithium has been used in the treatment of mania since 1949. Although its effectiveness is well recognized, the mechanism by which it stabilizes manic behavior is not well understood. In addition, it has some serious toxic properties combined with a narrow therapeutic range. For this reason, monitoring of serum lithium levels is mandatory. Suggested mechanisms of action and protocols for monitoring of serum levels are presented.
Aortic dissection in acute pancreatitis
Authors: Goff, II CDR Walter B. , Lawrence CDR David P. , Burkhard CDR Thomas K. 
Published: February 2019

Abstract
Extrapancreatic fluid collections are frequently seen in acute pancreatitis. Vascular damage with life-threatening hemorrhage is also a known complication. In the case report presented, we include documentation by computed tomography of an apparent abdominal aortic wall dissection by fluid in a patient with acute pancreatitis. Conservative therapy resulted in complete resolution without hemorrhage or aneurysm formation.
Mirizzi syndrome (hepatic duct obstruction)
Authors: Moult R. Gene , Wilczynski Michael , Mullangi Ureddi , Mehta Harsha 
Published: February 2019

Abstract
The Mirizzi syndrome is an uncommon cause of obstructive jaundice. In 1948, Mirizzi characterized a syndrome in which common hepatic duct obstruction occurs because of impacted stones in the gallbladder neck or cystic duct. The authors report a case demonstrating this syndrome. They discuss the radiographic features and report the features found on a computed tomographic cholangiogram that have not been previously described. Computed tomography-cholangiography may be helpful in evaluating patients with suspected Mirizzi syndrome.
Update on monoclonal antibody therapy in the gram-negative sepsis syndrome
Authors: Hecker Maj. Richard B. 
Published: February 2019

Abstract
Two multicenter controlled clinical trial~ of genetically engineered monoclonal antibodies directed against endotoxin, a potent mediator of inflammation in the gram-negative sepsis syndrome, were recently reported in the medical literature. One of these antiendotoxin antibodies was derived from a murine (mouse) source, and the other antibody was derived mainly from a human source (nebacumab [negative bacteria human monoclonal antibody D. This article reviews recent literature concerning' the use of these agents in the treatment of gram-negative sepsis syndrome. It also projects economic assessment data regarding the use of nebacumab in the United States.
The evolution of osteopathic manipulative technique: The Spencer technique
Authors: Patriquin David A. 
Published: February 2019

Abstract
The Spencer technique is a standardized series of shoulder treatments with broad application in diagnosis, treatment, and prognosis. The evolution of this technique is traced from 1916 to date to try to identify factors in the development of manipulative methods. Few suggestions about the basic steps to be followed in developing any new manipulative technique were seen. Of chief importance were changes in sequence, the addition of steps, and the combination of one technique with another, as in the addition of muscle-energy methods to each step. One change, accidentally introduced in the 1970s, displaced a critical step in the procedure. The principal element guiding the development of the Spencer technique appears to be clinical necessity interpreted in terms of anatomy and pathology.
A survey on zoo mortality over a 12-year period in Italy
Authors: Scaglione Frine Eleonora , Biolatti Cristina , Pregel Paola , Berio Enrica , Cannizzo Francesca Tiziana , Biolatti Bartolomeo , Bollo Enrico 
Published: February 2019

Background
The zoo is a unique environment in which to study animals. Zoos have a long history of research into aspects of animal biology, even if this was not the primary purpose for which they were established. The data collected from zoo animals can have a great biological relevance and it can tell us more about what these animals are like outside the captive environment. In order to ensure the health of all captive animals, it is important to perform a post-mortem examination on all the animals that die in captivity.

Methods
The causes of mortality of two hundred and eighty two mammals which died between 2004 and 2015 in three different Italian zoos (a Biopark, a Safari Park and a private conservation center) have been investigated.

Results
Post mortem findings have been evaluated reporting the cause of death, zoo type, year and animal category. The animals frequently died from infectious diseases, in particular the causes of death in ruminants were mostly related to gastro-intestinal pathologies. pulmonary diseases were also very common in each of the zoos in the study. Moreover, death was sometimes attributable to traumas, as a result of fighting between conspecifics or during mating. Cases of genetic diseases and malformations have also been registered.

Discussion
This research was a confirmation of how conservation, histology and pathology are all connected through individual animals. These areas of expertise are extremely important to ensure the survival of rare and endangered species and to learn more about their morphological and physiological conditions. They are also useful to control pathologies, parasites and illnesses that can have a great impact on the species in captivity. Finally, this study underlines the importance of a close collaboration between veterinarians, zoo biologists and pathologists. Necropsy findings can help conservationists to determine how to support wild animal populations.
UNDULAR BORE DEVELOPMENT OVER A LABORATORY FRINGING REEF
Authors: Tissier Marion , Dekkers Jochem , Reniers Ad , Pearson Stuart , Van Dongeren Ap 
Published: February 2019

Several studies have reported the development of
undular bores over fringing coral reefs (e.g, Gallagher,
1976; Nwogu and Demirbilek, 2010) but the importance
of this phenomenon for reef hydrodynamics has never
been studied. Yet, the transformation of a long wave
(e.g., swell or infragravity wave) into an undular bore
leads to significant modifications of the wave field. The
formation of undulations is for example associated to a
significant increase of the leading bore height. Moreover,
if the undulations have enough time to develop (i.e. if the
reef flat is wide enough), the initial long wave will
ultimately split into a series of solitons (e.g., Grue et al.,
2008). All this is likely to affect wave run-up. As reeffronted
coastlines are particularly vulnerable to flooding,
a good understanding of long wave transformation over
the reef flat, including their possible transformation into
undular bores, is crucial.
In this study, we investigate undular bore development
over reef-type profiles based on a series of laboratory
experiments. More specifically, we aim to characterize
the conditions under which undular bores develop, and
analyse how their development affect the hydrodynamics
at the toe of the reef-lined beach and the resulting wave
run-up.
Ultrafast Field‐Emission Electron Sources Based on Nanomaterials
Authors: Zhou Shenghan , Chen Ke , Cole Matthew Thomas , Li Zhenjun , Chen Jun , Li Chi , Dai Qing 
Published: February 2019

AbstractThe search for electron sources with simultaneous optimal spatial and temporal resolution has become an area of intense activity for a wide variety of applications in the emerging fields of lightwave electronics and attosecond science. Most recently, increasing efforts are focused on the investigation of ultrafast field‐emission phenomena of nanomaterials, which not only are fascinating from a fundamental scientific point of view, but also are of interest for a range of potential applications. Here, the current state‐of‐the‐art in ultrafast field‐emission, particularly sub‐optical‐cycle field emission, based on various nanostructures (e.g., metallic nanotips, carbon nanotubes) is reviewed. A number of promising nanomaterials and possible future research directions are also established.
Substituent Effect in the Synthesis of α,α‐Dibromoketones, 1,2‐Dibromalkenes, and 1,2‐Diketones from the Reaction of Alkynes and Dibromoisocyanuric Acid
Authors: Cho Eunjeong , Jayaraman Aravindan , Lee Junseong , Ko Kyoung Chul , Lee Sunwoo 
Published: February 2019

AbstractInternal alkynes reacted with dibromoisocyanuric acid/H2O to afford α,α‐dibromoketone and 1,2‐diketone derivatives. Diarylalkynes with activating groups provided 1,2‐diketone derivatives as the major products, whereas diarylalkynes with a non‐activating group or alkylarylalkynes gave α,α‐dibromoketone derivatives as the major products. In addition, diarylalkynes with deactivating groups provided 1,2‐dibromoalkenes. The reaction was conducted at room temperature and showed good yields in most cases. Reaction pathways have been proposed on the basis of experimental observations and density functional theory (DFT) calculations.magnified image
Nonvolatile Electric‐Field Control of Ferromagnetic Resonance and Spin Pumping in Pt/YIG at Room Temperature
Authors: Yu Rui , He Kang , Liu Qi , Gan Xucheng , Miao Bingfeng , Sun Liang , Du Jun , Cai Hongling , Wu Xiaoshan , Wu Mingzhong , Ding Haifeng 
Published: February 2019

AbstractElectric‐field‐controlled magnetism is of importance in realizing energy efficient, dense and fast information storage and processing. Strain‐mediated converse magneto‐electric (ME) coupling between ferromagnetic and ferroelectric heterostructure shows promise for realizing electric‐controlled magnetism at room temperature and is attracting a number of recent investigations. However, such ME‐effect studies have mainly focus on magnetic metals. In this work, high quality yttrium iron garnet (Y3Fe5O12 (YIG)) films are deposited directly onto (100)‐oriented single‐crystal Pb (Mg1/3Nb2/3)0.7Ti0.3O3 (PMN‐PT) substrates by means of magnetron sputtering. The electric‐field‐induced polarization switching and lattice strain in the PMN‐PT substrate results in two distinct magnetization states in the YIG film that are nonvolatile and electrically reversible. Because of the direct contact between the YIG and the PMN‐PT substrate, an efficient ME coupling and an almost 90° rotation of the easy axis of the YIG film can be realized. Furthermore, the electric‐field‐controlled hysteresis loop‐like ferromagnetic resonance field shifts and spin pumping signals are observed in Pt/YIG/PMN‐PT heterostructures. Thus, the obstacle is overcome via growing high‐quality YIG thin films directly onto PMN‐PT substrates and an efficient manipulation of magnetism and pure spin current transport by electric field is thereby realized. These findings are instructive for future low‐power magnetic insulator‐based spintronic devices.
Effects of glycol on adsorption dynamics of idealized water droplets on LTA‐3A zeolite surfaces
Authors: Olsen Richard , Kvamme Bjørn 
Published: February 2019

AbstractDuring production of natural gas, glycol may follow the gas stream due to hydrate prevention or glycol dehumidification. Further dehumidification can be achieved by Linde Type A‐3A zeolite. Local glycol concentrations can form through adsorption to surrounding clay material or zeolite, thus blocking zeolite windows or contaminating condensed water droplets close to the surface. Idealized nanoscale water droplets and their adsorption dynamics onto zeolite structures were simulated, with and without glycol contamination. Blockage of the zeolite windows was also investigated. Water from contaminated droplets adsorbed slower than uncontaminated droplets due to hindrance caused by glycols adsorbed to the zeolite surfaces, thus decreasing initial water loading rates. The adsorption free energy barrier of water was higher for D4R‐terminated zeolite than for alpha cavity‐terminated zeolite. Adsorbed glycols blocked zeolite cavities. However, temperature increase resulted in partial desorption of the glycols, while water desorbed at a lower temperature than for glycol.
Polymer bilayers with enhanced dielectric permittivity and low dielectric losses by Maxwell–Wagner–Sillars interfacial polarization: Characteristic frequencies and scaling laws
Authors: Samet M. , Kallel A. , Serghei A. 
Published: February 2019

ABSTRACTAn efficient approach to obtain polymeric materials with high permittivity values and low dielectric losses is presented in the current study. For this purpose, dielectric measurements by means of broadband dielectric spectroscopy, numerical simulations, and analytical calculations have been carried out for bilayer structures consisting in an insulating and a conductive polymer layer. Polyethyleneterephtalate and polytetrafluoroethylene have been used as insulating layers while, as conductive materials, blends of polyvinyl acetate with an ionic liquid, 1‐butyl‐3‐methylimidazolium tetrafluoroborate. The dielectric properties of the samples have been investigated in a broad frequency (from 10−1 to 107 Hz) and temperature range in order to determine, through the analysis of the scaling laws governing the interfacial polarization effects, the characteristic frequency ranges and the amplitude of the enhanced permittivity. An excellent agreement is found between the experimental results, the numerical simulations, and the analytical calculations. Finally, we show that bilayer polymeric materials with permittivity values as high as ε′ = 556 and with low dielectric losses (tan(δ) = 0.001) can be readily obtained by the current approach. This could have multiple applications, especially in the field of organic electronics. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47551.
Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels forin vitrocontrolled release of vitamin B12
Authors: Nath Jayashree , Chowdhury Anupam , Ali Ilias , Dolui Swapan Kumar 
Published: February 2019

ABSTRACTGelatin (Ge)‐g‐poly(acrylic acid‐co‐acrylamide) and montmorillonite (MMT)‐clay‐based nanocomposite hydrogels were fabricated to study the controlled release of vitamin B12. Polymeric hydrogels were characterized with Fourier transform infrared (FTIR) spectroscopy, X‐ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). FTIR spectroscopy confirmed the grafting of partially neutralized acrylic acid on a Ge backbone. The incorporation of MMT fillers inside the nanocomposite hydrogels and their increased crystallinity were established by XRD analysis. The rough surface morphologies of the composite hydrogels shown by SEM resulted from the assimilation of MMT inside the same. TEM confirmed the formation of nanosized composites. The average length and width of the MMT platelets were found to be 184.37 and 20.48 nm, respectively. The maximum swelling of the hydrogel was 375 g/g, and the results were established with Design‐Expert software. The biodegradability of the nanocomposite increased in comparison to that of the copolymer hydrogel. Biocompatibility and cytotoxicity studies were also performed. During different time intervals, the controlled release of vitamin B12in artificial gastric fluid (AGF) and artificial intestinal fluid (AIF) was evaluated with a UV–visible spectrophotometer; this resulted in different controlled release curves. The release in AGF was 42%, and in AIF, the cumulative release was 80% over 6 h. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2019,136, 47596.
Carbon‐Free Cathode Materials for Li−O2 Batteries
Authors: Cao Deqing , Zhang Shuaishuai , Yu Fengjiao , Wu Yuping , Chen Yuhui 
Published: February 2019

AbstractRechargeable lithium‐oxygen batteries, especially the nonaqueous lithium‐oxygen batteries have attracted much attention in recent years due to their high energy densities. However, few critical challenges remain to be overcome, including the low round‐trip efficiency, high charge overpotential, poor cycling performance, decomposition of electrolyte, and instability of the carbon‐based electrode. Among these, the instability of the carbon‐based electrode is one of the major problems that hindered the practical application of the Li−O2 batteries. Much work has been done to solve this problem and there are two widely‐applied strategies: modification of carbon and designing a “carbon‐free” cathode. In this review, we will introduce recent achievements of both strategies.
Determination of oxytetracycline hydrochloride in milk and egg white samples using Ru(bipy)32+–Ce(SO4)2 chemiluminescence
Authors: Xing‐yu Long , Jiang‐ning Gong , Mao Deng , Di Wu , Zhuo Chen , Pin‐hua Xia , Xiao‐jian Gong , Qin Deng , Zhi‐hui Shi , Xue‐mei Yan , Ru‐qing Tian , Cai‐yun Jiang 
Published: February 2019

AbstractA novel, rapid and sensitive chemiluminescence (CL) method for the determination of oxytetracycline hydrochloride (OTCH) is described in this paper. The presented method was based on the fact that OTCH could immensely enhance the CL of the reaction of cerium sulfate and tris(2,2‐bipyridyl) ruthenium (II) in acidic medium. Under optimal experimental conditions, CL intensity was favorably linear for OTCH in the range 5.0 × 10−7 to 5.0 × 10−5 g/ml, with a detection limit of 1.5 × 10−7 g/ml (S/N = 3). The relative standard detection was 4.76% for 5.0 × 10−6 g/ml (n = 11). This method was successfully applied to the analysis of OTCH in milk and egg white samples. According to the results of the kinetic curves for OTCH in the Ru(bipy)32+–Ce(SO4)2 CL system, together with CL and ultraviolet (UV)–visible spectra, the possible mechanism of the CL reaction is discussed briefly.
Undergraduate lab series using the K562 human leukemia cell line: Model for cell growth, death, and differentiation in an advanced cell biology course
Authors: Phelan Shelley A. , Szabo Elizabeth 
Published: February 2019

AbstractThis sequence of labs was developed for an upper level undergraduate cell biology course at Fairfield University. The labs are based on the use of the K562 human erythroleukemia cell line, a model system that is exceptionally amenable to an undergraduate cell biology lab course due to its ease of maintenance and propagation and usefulness for studies of growth, death, and differentiation. The sequence of labs is conducted over a 6‐week period, following a series of weekly cell biology labs covering basic cell and molecular biology techniques. Together, the lab series has four primary objectives 1) to teach students how to culture and maintain mammalian cells; 2) to build student competency in standard cell biology techniques; 3) to demonstrate the role of growth factors on cell proliferation and viability; and 4) to provide students with an opportunity to use these cells in an independent investigation on cell differentiation. We provide examples of student data and offer a range of experimental measurements depending on institutional capacity and facilities. Our assessment data suggest that students find great value in this lab series, enhancing their comprehension of key concepts, acquisition of important lab skills, and depth of understanding of the research process. © 2019 International Union of Biochemistry and Molecular Biology, 47(3):263–271, 2019.
A novel, rapid and sensitive UPLC–MS/MS method for the determination of macitentan in patients with pulmonary arterial hypertension
Authors: Albayrak Mevlut , Atıla Alptug , Yılmazel Ucar Elif , Araz Omer , Kadıoglu Yucel 
Published: February 2019

AbstractMacitentan is an endothelin receptor antagonist commonly used in the treatment of pulmonary arterial hypertension (PAH). A novel, rapid, simple and sensitive UPLC–MS/MS method was developed and validated for pharmacokinetic study and the determination of macitentan in PAH patients. Macitentan and bosentan, which are used as internal standards, were detected using atmospheric pressure chemical ionization in positive ion and multiple reaction monitoring mode by monitoring the mass transitions m/z 589.1 → 203.3 and 552.6 → 311.5, respectively. Chromatographic separation was performed on a reverse‐phase C18 column (5 μm, 4.6 × 150 mm) with an isocratic mobile phase, which consisted of water containing 0.2% acetic acid–acetonitrile (90:10, v/v) at a flow rate of 1 mL/min. Retention times were 1.97 and 1.72 min for macitentan and IS, respectively. The calibration curve with high correlation coefficient (0.9996) was linear in the range 1–500 ng/mL. The lower limit of quantitation and average recovery values were determined as 1 ng/mL and 89.8%, respectively. This method is the first UPLC–MS/MS method developed and validated for the determination of macitentan from human plasma. The developed analytical method was fully validated for linearity, selectivity, specificity, accuracy, precision, sensitivity, stability, matrix effect and recovery according to US Food and Drug Administration guidelines. The developed method was applied successfully for pharmacokinetic study and the determination of macitentan in PAH patients.