bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor de Wilms: experiencia de 12 años en dos hospitales de alto nivel en Medellín, Colombia
Authors: Herrera-Toro Natalia , Peña-Aguirre Laura , Arango-Rave María Elena 
Published: May 2019

Objetivo: describir la epidemiología y los resultados en el manejo de los niños menores de 15 años con el diagnóstico de tumor de Wilms (TW) en dos hospitales de alto nivel de complejidad en un período de 12 años.Métodos: estudio de seguimiento a una cohorte retrospectiva. Se revisaron las historias clínicas de pacientes con diagnóstico de TW entre enero de 2005 y mayo de 2017, buscando información centrada en edad, forma de presentación, confirmación histopatológica y estratificación del tumor, tipo de tratamiento ofrecido y desenlaces en el seguimiento relacionados con recaída y supervivencia.Resultados: en total se encontraron 84 pacientes con el diagnóstico de TW, con un promedio de edad de presentación de 3 años. Predominó el estadio III al momento del diagnóstico y la principal presentación fue masa abdominal. El 8,3 % de los pacientes tuvieron histología desfavorable. El tiempo promedio de supervivencia libre de recaída fue 97 meses. A los 108 meses después del diagnóstico, la supervivencia fue del 71 %. En nuestros hospitales se realiza nefrectomía inicial (protocolo COG/NWTS). El 39 % de los pacientes fueron sometidos a quimioterapia prequirúrgica, la cual se rigió en el 72,7 % con el protocolo SIOP y 27,3 % con el COG/NWTS.Conclusiones:en los dos hospitales analizados, el manejo del TW se rige por el protocolo del COG/NWTS con nefrectomía inicial y posterior quimioterapia. Un grupo de pacientes son llevados a quimioterapia prequirúrgica con las mismas indicaciones descritas en el protocolo americano. El diagnóstico de nuestros pacientes es con mayor frecuencia en estadios avanzados. La supervivencia en esta serie, 71 %, es menor que la reportada en la literatura mundial, 93 %.
A 5-Week Seminar on the Biopsychosocial-Spiritual Model of Self-Care Improves Anxiety, Self-Compassion, Mindfulness, Depression, and Stress in Graduate Healthcare Students
Authors: Klawonn Amisha , Kernan Dana , Lynskey James 
Published: May 2019

Abstract
Graduate healthcare students can experience stress that affects their ability to perform academically and clinically, decreases empathy, and affects their well-being and clinical competence. The purpose of the current study was to determine the effects of a seminar on a yoga-inspired biopsychosocial-spiritual model of self-care on perceived levels of anxiety, self-compassion, mindfulness, depression, and stress in graduate healthcare students. We used a within-group repeated-measure design with baseline followed by intervention. The intervention was a 5-week seminar with 60-minute sessions that incorporated breathing, mindful movement, meditation, and education for self-care in five areas of a biopsychosocial-spiritual model (spiritual, physical, intellectual, energetic, and psychoemotional-social). The following outcomes measures assessed perceived changes in anxiety, self-compassion, mindfulness, depression, and stress: Beck Anxiety Inventory (BAI), Self-Compassion Scale–Short Form (SCS-SF), Freiburg Mindfulness Inventory (FMI), Kentucky Inventory of Mindfulness Skills (KIMS), Mindfulness Attention Awareness Scale (MAAS), Beck Depression Inventory (BDI), and Perceived Stress Scale (PSS). The Freidman test with Dunn's test post hoc pairwise comparisons was used for the BAI, SCS-SF, FMI, KIMS, and MAAS. A Wilcoxon signed-rank test was used for BDI and PSS. Twenty doctor of physical therapy students and one doctor of dental medicine student participated in the study. Significant improvements (all p &lt; 0.05) were found for self-compassion, mindfulness, anxiety, depression, and stress. A 5-week seminar using a biopsychosocial-spiritual approach for self-care improved self-compassion and mindfulness and diminished anxiety, depression, and stress. Implementing programs that facilitate self-awareness and self-care may provide important benefits to future healthcare providers.
Female Patients and Informed Consent: Oman’s cultural background
Authors: Al Balushi Amal A. 
Published: May 2019

Female patients in Oman face a certain amount of pressure from their families when making high-stakes decisions regarding personal healthcare. In fact, some women waive their right to make decisions, typically giving that responsibility to their husbands or fathers. This article highlights the need to empower females in decision-making when it comes to their own well-being. Moreover, informed consent should not be signed by anyone but the patient herself if the patient is deemed competent by a medical professional. Keywords: Informed Consent; Female; Decision Making; Clinical Competence; Medical Ethics; Patient Rights; Oman.
Randomised Trial of Oral Misoprostol Versus Manual Vacuum Aspiration for the Treatment of Incomplete Abortion at a Nigerian Tertiary Hospital
Authors: Ibiyemi Kehinde F. , Ijaiya Munir'deen A. , Adesina Kikelomo T. 
Published: May 2019

Objectives: This study aimed to compare the efficacy of oral misoprostol with manual vacuum aspiration (MVA) in first trimester incomplete abortions. Methods: This randomised controlled trial study was conducted at the University of Ilorin Teaching Hospital, Ilorin, Nigeria between April 2014 and November 2015. Pregnant women who presented with clinical features of incomplete abortion at a gestational age of 13 weeks or less were included. Patients who had profuse vaginal bleeding, an intrauterine device in situ, signs of pelvic infections or who were younger than 18 years old and had no accompanying adults to give informed consent were excluded. A total of 200 participants were randomly and equally allocated to either the MVA or misoprostol treatment group. The treatment group were given 600 μg of misoprostol orally. The primary outcome measure was complete uterine evacuation, while secondary outcome measures included the need for additional surgical evacuation for failed treatment, adverse effects/complications, acceptability of and satisfaction with the treatment. Results: Both misoprostol and MVA had high complete evacuation rates, yet MVA was significantly higher (99% versus 83%, relative risk [RR]: 0.84, confidence interval [CI]: 0.766–0.918; P <0.001). Significantly more women in the misoprostol group required additional MVA for failed treatment than in the MVA treatment group (17% versus 1%, RR: 16.67, CI: 2.260–12.279; P <0.001). No significant difference was found between the misoprostol and MVA treatment groups in terms of satisfaction (92.7% versus 89.8%, RR: 1.04, CI: 0.946–1.127; P = 0.473). Conclusion: Treatments with misoprostol and MVA had high complete uterine evacuation rates, as well as high rates of acceptability and satisfaction. However, MVA had a significantly higher complete evacuation rate than misoprostol.Keywords: Misoprostol; Abortion Techniques; First Trimester; Incomplete Abortion; Nigeria.
Authors’ Selection of Target Journals and Their Attitudes to Emerging Journals: A survey from two developing regions
Authors: Beshyah Salem A. 
Published: May 2019

Objectives: This study aimed to assess the factors that influence authors' decision when choosing a journal for publication and to assess authors' attitudes and practices regarding emerging journals. Methods:cross-sectional questionnaire-based study was conducted between April and July 2017 at Dubai Medical College, Dubai, United Arab Emirates, on a convenience sample of 2,764 healthcare professionals. Results: A total of 250 responses were received (response rate: 9%) and 152 valid respondents were included in this study (5.6%), of which the majority were male (61.2%) and aged 41–60 years (68%) from the Middle East and Africa. Most respondents (88.8%) had medical and/or dental qualifications and the majority were in senior clinical (55%) and academic (71.5%) positions. More than half of the respondents (62.5%) had published at least one article in the previous five years. Results showed that journal impact factor (JIF), indexation status, free submission and being international were important among respondents. Based on the respondents that shared their encounters with emerging journals (n = 114), 62 respondents (54.4%) regularly read certain emerging journals, 51 (44.7%) had been a peer-reviewer, 48 (42.1%) had cited content from an emerging journal at least once and 45 (39.5%) had published in emerging journals. Only 18 respondents (14.2%) were not convinced with the need for emerging journals and believed that all researchers should compete for publication in the same international journals. Conclusion: Selection of target journals is driven mainly by JIF, indexation status, free submission and a journal’s international status. A diverse range of opinions and attitudes regarding emerging journals were observed in this study. Keywords: Journal Impact Factor; Open Access Publishing; Editorial Policy; Peer Review; Indexing; Publications; Attitude; United Arab Emirates.
Obstetrics and Gynaecology as a Future Career for Medical Graduates in Oman: Factors that attract and discourage graduates
Authors: Al Salehi Asma , Al Dughaishi Tamima , Rizvi Gauhar , Gowri Vaidyanathan 
Published: May 2019

Objectives: Obstetrics and gynaecology (OBGYN) is a major speciality in the medical field that is often demanding yet rewarding; however, OBGYN receives the least number of applicants in Oman. This study aimed to determine the factors that influence graduates in choosing OBGYN as their speciality. Methods: This cross-sectional questionnaire-based study was conducted from February to March 2017 at Sultan Qaboos University Hospital, Royal Hospital, Khoula Hospital and Al Nahdha Hospital, Muscat, Oman. The questionnaire was distributed to 150 Omani medical graduates (interns and post-intern doctors). Results: A total of 145 Omani graduates took part in the study (response rate: 96.7%) and the participants’ average age was 26 years. Family medicine ranked as the first choice followed by paediatrics and emergency medicine. OBGYN was the first choice for eight female graduates. The top factors attracting male graduates to the OBGYN speciality were its surgical opportunities (80.6%), intellectual content (77.4%), faculty interactions and the opportunity to care for a healthy population (54.8% each); however, the top factors attracting females were the intellectual content (88.6%), patients’ desire for female physicians (85.1%), the opportunity to care for a healthy population (76.3%) and cultural expectations (69.5%). The most discouraging factors for male graduates were cultural expectations (100%), the patients’ desire for a female physician (93.5%) and the level of stress (71%), while the discouraging factors for female graduates were the level of stress (82.5%), time demands (78.1%), night duties and the length of the residency (71.9% each). Conclusion: Most of the factors that discourage female graduates from choosing OBGYN are to some extent modifiable. These changes should be considered to encourage the selection of OBGYN as a career by medical students.Keywords: Career Choice; Obstetrics and Gynecology Department, Hospital; Internship and Residency; Medical Student; Oman.
MULTILEVEL SYSTEM OF FORMATION OF MATHEMATICAL COMPETENCE OF TEACHING ENGINEERING PROFILE UNDER TERMS OF CONTINUOUS EDUCATION
Authors: Ilyashenko Lubov K. 
Published: May 2019

Purpose of Study: The aim of this paper was designing a multi-stage model for the learning of maths of engineering college students under continuous learning.This was a content analysis study, then we first outlined the basic and key mathematical topics that engineering students should be mastering. We then identified a multi-stage model of expected learning levels for each of these topics, after that, we categorized the topics based on the levels desired and put them in the form of a pattern of continuous learning courses and finally, the time and type of evaluation were determined in each period. Accordingly, the length of each period was considered to be 3 months, and the upgrade criterion in each curse was considered as a step in 80% of the topics.
Methodology: This was a content analysis study, in which mathematical topics were first categorized in the field of engineering.
Results: In this research, a five-level model was designed in 12 courses. The criterion for determining the levels, the degree of deepening and the importance of learning, and for the determination of curses, were the key to the basic concepts and concepts that students had difficulty with. The model was designed in five levels, moving from top to bottom, math problems became more abstract and complex. Then, for each level, steps were taken to determine the expectations of the course for students.
Implications/Applications: Mathematical concepts are crucial in engineering, but students over time forget them and face a lot of problems in their work. Accordingly, it is imperative to use This model for continuous learning of these concepts for Russian engineering students.
Editorial Responsibilities
Authors: .. .. 
Published: May 2019

Editors
Jessica Lange, Editor-in-Chief, McGill University
Giovanna Badia, Guest Editor, McGill University
Linda Ecclestone, Section Editor (Book Reviews), Lasalle Secondary School
Éthel Gamache, Section Editor (French Language), Concordia University
Corinne Gilroy, Layout Editor, Mount Saint Vincent University
Krista Godfrey, Production Editor, Memorial University of Newfoundland
Jen Hoyer, Section Editor (Innovations in Practice), Brooklyn Public Library
Tamara Noor, Section Editor (Features), OCAD University
Rainer Schira, Layout Editor, Brandon University
Ann Smith, Section Editor (Theory & Research), Acadia University
Copyeditors
Lindsay McNiff, Lead Copyeditor, Dalhousie University
Chris Landry, OCAD University
Allana Mayer, OurDigitalWorld
Emily Tyschenko, Guelph Public Library
Greg Nightingale, Western University
Dahlal Mohr-Elzeki, McGill University Health Centre
Andrea Quaiattini, McGill University
Proofreaders
Deborah Hemming, Simon Fraser Univeristy
Mylène Pinard, McGill University
Tanya Ulmer, Internet Archive Canada (Alberta)
Social Media & Web Design
Graham Lavender, Web Design Coordinator, Michener Institute of Education at UHN
Natalie Colaiacovo, Digital & Social Media Coordinator, Centennial College
Translation
Patrick Labelle, Translator, University of Ottawa
Real-Time Well-Integrity Monitoring Using Fiber-Optic Distributed Acoustic Sensing
Authors: Raab T.. , Reinsch T.. , Aldaz Cifuentes S. R. , Henninges J.. 
Published: May 2019

Summary
Proper cemented casing strings are a key requirement for maintaining well integrity, guaranteeing optimal operation and safe provision of hydrocarbon and geothermal resources from the pay zone to surface facilities. Throughout the life cycle of a well, high–temperature/high–pressure changes in addition to shut–in cyclic periods can lead to strong variations in thermal and mechanical load on the well architecture. The current procedures to evaluate cement quality and to measure downhole temperature are mainly dependent on wireline–logging campaigns. In this paper, we investigate the application of the fiber–optic distributed–acoustic–sensing (DAS) technology to acquire dynamic axial–strain changes caused by propagating elastic waves along the wellbore structure. The signals are recorded by a permanently installed fiber–optic cable and are studied for the possibility of real–time well–integrity monitoring.
The fiber–optic cable was installed along the 18⅝–in. anchor casing and the 21–in.–hole section of a geothermal well in Iceland. During cementing operations, temperature was continuously measured using distributed–temperature–sensing (DTS) technology to monitor the cement placement. DAS data were acquired continuously for 9 days during drilling and injection testing of the reservoir interval in the 12¼–in. openhole section. The DAS data were used to calculate average–axial–strain–rate profiles during different operations on the drillsite. Signals recorded along the optical fiber result from elastic deformation caused by mechanical energy applied from inside (e.g., pressure fluctuations, drilling activities) or outside (e.g., seismic signals) of the well. The results indicate that the average–axial–strain rate of a fiber–optic cable installed behind a casing string generates trends similar to those of a conventional cement–bond log (CBL). The obtained trends along well depth therefore indicate that DAS data acquired during different drilling and testing operations can be used to monitor the mechanical coupling between cemented casing strings and the surrounding formations, hence the cement integrity. The potential use of DTS and DAS technology in downhole evaluations would extend the portfolio to monitor and evaluate qualitatively in real time cement–integrity changes without the necessity of executing costly well–intervention programs throughout the well's life cycle.
High rates of culture conversion and low loss to follow-up in MDR-TB patients managed at Regional Referral Hospitals in Uganda
Authors: Mbonye Martin Kayitale , Otuba John-Paul , Riese Sara , Alima Hilary , Mugabe Frank , Muhwezi Augustin K , Turyahabwe Stavia , Wandera Christopher , Zanten Tisna Veldhuijzen van , Tugume Gladys 
Published: May 2019

Abstract
Background: Multi-drug resistant – tuberculosis (MDR-TB) is an emerging public health concern in Uganda. Prior to 2013, MDR-TB treatment in Uganda was only provided at the national referral hospital and two private-not-for profit clinics. From 2013, it was scaled up to seven regional referral hospitals (RRH). The aim of this study was to measure interim (six months) treatment outcomes among the first cohort of patients started on MDR-TB treatment at the RRH in Uganda.
Methods: This was a cross-sectional study in which a retrospective descriptive analysis of data on a cohort of 69 patients started on MDR-TB treatment at 7 RRH between 1st April 2013 and 30th June 2014 and had been on treatment for at least nine months was conducted.

Results: Of the 69 patients, 21 (30.4%) were female, 39 (56.5%) HIV-negative, 30 (43.5%) resistant to both isoniazid and rifampicin and 57 (82.6%) category 1 or 2 drug susceptible TB treatment failures. Median age at start of treatment was 35 years (Interquartile range (IQR): 27-45), median time-to-treatment initiation was 27.5 (IQR:6-89) days and of the 30 HIV-positive patients, 27 (90.0%) were on anti-retroviral treatment with a median CD4 count of 206 cells/microliter of blood (IQR: 113-364.5). Within six months of treatment, 59 (86.0%) patients culture converted, of which 45 (65.2%) converted by the second month and the other 14 (20.3%) by the sixth month; one (1.5%) did not culture convert; three (4.4%) died; and six (8.8%) were lost-to-follow up. Fifty (76.8%) patients experienced at least one drug adverse event, while 40 (67.8%) gained weight. Mean weight gained was 4.7 (standard deviation:3.2) kilograms.

Conclusions: Despite MDR-TB treatment initiation delays, most patients had favourable interim treatment outcomes with majority culture converting early and very few getting lost to follow-up. These encouraging interim outcomes indicate a successful scale-up of MDR-TB treatment to RRH.
Identification of a novel mutation in the CACNA1C gene in a Chinese family with autosomal dominant cerebellar ataxia
Authors: Chen Jiajun , Sun Yajuan , Liu Xiaoyang , Li Jia 
Published: May 2019

Abstract
Background: Hereditary ataxia is a group of neurodegenerative diseases with progressive cerebellar ataxia of the gait and limbs as the main symptoms. The genetic patterns of the disease are diverse but it is mainly divided into autosomal dominant cerebellar ataxia (ADCA) and autosomal recessive cerebellar ataxia (ARCA), and about 45 pathogenic loci have been found in ADCA. The purpose of this study was to explore the genetic defect in a Chinese family with ADCA. Methods: A three-generation Chinese family with ADCA was enrolled in this study, Exome sequencing was conducted in four family members, including the proband, and verified by Sanger sequencing. Results: The rs779393130 mutation of the CACNA1C gene co-segregated with the ataxia phenotype in this family. The mutation was not detected in 50 unaffected controls. Conclusions: The rs779393130 mutation of CACNA1C may be associated with the phenotype of the disease. The CACNA1C gene encodes the Cav1.2 (alpha-1) subunit of an L-type calcium channel and this subunit may be related to the ADCA phenotype. These findings may have implications for family clinical monitoring and genetic counseling and may also help in understanding pathogenesis of this disease.
Jakyakgamcho-tang in the Relief of Delayed-Onset Muscle Soreness in Healthy Adults: study protocol for a randomized, double-blind, placebo-controlled, cross-over design clinical trial
Authors: Han Kyungsun , Kwon Ojin , Jung So-Young , Park In-hwa , Hwang Man-Suk , Park Sun-Young , Hwang Eui-Hyoung , Lee Jun-Hwan 
Published: May 2019

Abstract
Background

Muscle soreness after exercise, or so-called delayed onset muscle soreness (DOMS), may cause significant changes to muscle function and may increase the risk of sports injuries. Therefore, various therapeutic strategies have been studied to help recovery after exercise. Jakyakgamcho-tang (JGT) is a widely prescribed herbal medicine to treat muscle pain and cramps in traditional Eastern medicine. The aim of this study was to evaluate the effect of JGT for reducing pain and improving muscle damage after exercise.

Methods

This study is a randomized, double-blind, placebo-controlled, cross-over design clinical trial. A total of 30 healthy male adults will be recruited. Subjects who voluntarily wish to participate in this study will be hospitalized for 4 days. On the first day, the subjects will perform a standardized treadmill exercise for 1 hour to induce DOMS. After the exercise, the subjects will take either JGT or a placebo for 3 days. After a more than 1 week wash-out period, the subjects will repeat the same process with the other drug. Pain intensity, calf circumference, and pain threshold will be measured as outcome measures. Blood tests and blood pressure will be measured as safety assessments. In addition, blood tests for muscle damage and inflammation markers, such as creatine kinase, interleukin-6, and C-reactive protein will be analyzed.

Discussion

This will be the first trial to assess the effect of JGT on exercise-induced muscle soreness. Our findings will provide valuable data to determine the clinical effects of JGT on DOMS.