bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of survival and progression in behavioural variant frontotemporal dementia
Authors: Agarwal S. , Ahmed R. M. , D'Mello M. , Foxe D. , Kaizik C. , Kiernan M. C. , Halliday G. M. , Piguet O. , Hodges J. R. 
Published: December 2018

Background and purposePredicting the course of behavioural variant frontotemporal dementia (bvFTD) remains a major clinical challenge. This study aimed to identify factors that predict survival and clinical progression in bvFTD.MethodsConsecutive patients with clinically probable bvFTD were prospectively followed up over an 8‐year period. Baseline neuropsychological variables, presence of a known pathogenic frontotemporal dementia gene mutation and a systematic visual magnetic resonance imaging assessment at baseline were examined as candidate predictors using multivariate modelling.ResultsAfter screening 121 cases, the study cohort consisted of 75 patients with probable bvFTD, with a mean age of 60.8 ± 8.5 years, followed up for a mean duration of 7.2 ± 3.5 years from symptom onset. Median survival time from disease onset was 10.8 years and median survival, prior to transition to nursing home, was 8.9 years. A total of 25 of the 75 patients died during the study follow‐up period. Survival without dependence was predicted by shorter disease duration at presentation (hazard ratio, 0.49, P = 0.001), greater atrophy in the anterior cingulate cortex (hazard ratio, 1.75, P = 0.047), older age (hazard ratio, 1.07, P = 0.026) and a higher burden of behavioural symptoms (hazard ratio, 1.04, P = 0.015).In terms of disease progression, presence of a known pathogenic frontotemporal dementia mutation (β = 0.46, P < 0.001) was the strongest predictor of progression. Deficits in letter fluency (β = −0.43, P = 0.017) and greater atrophy in the motor cortex (β = 0.51, P = 0.03) were also associated with faster progression.ConclusionsThis study provides novel clinical predictors of survival and progression in bvFTD. Our findings are likely to have an impact on prognostication and care planning in this difficult disease.
Patterns of genetic differentiation in Colorado potato beetle correlate with contemporary, not historic, potato land cover
Authors: Crossley Michael S. , Rondon Silvia I. , Schoville Sean D. 
Published: December 2018

AbstractChanging landscape heterogeneity can influence connectivity and alter genetic variation in local populations, but there can be a lag between ecological change and evolutionary responses. Temporal lag effects might be acute in agroecosystems, where land cover has changed substantially in the last two centuries. Here, we evaluate how patterns of an insect pest’s genetic differentiation are related to past and present agricultural land cover change over a 150‐year period. We quantified change in the amount of potato, Solanum tuberosum L., land cover since 1850 using county‐level agricultural census reports, obtained allele frequency data from 7,408 single‐nucleotide polymorphism loci, and compared effects of historic and contemporary landscape connectivity on genetic differentiation of Colorado potato beetle, Leptinotarsa decemlineata Say, in two agricultural landscapes in the United States. We found that potato land cover peaked in Wisconsin in the early 1900s, followed by rapid decline and spatial concentration, whereas it increased in amount and extent in the Columbia Basin of Oregon and Washington beginning in the 1960s. In both landscapes, we found small effect sizes of landscape resistance on genetic differentiation, but a 20× to 1,000× larger effect of contemporary relative to historic landscape resistances. Demographic analyses suggest population size trajectories were largely consistent among regions and therefore are not likely to have differentially impacted the observed patterns of population structure in each region. Weak landscape genetic associations might instead be related to the coarse resolution of our historical land cover data. Despite rapid changes in agricultural landscapes over the last two centuries, genetic differentiation among L. decemlineata populations appears to reflect ongoing landscape change. The historical landscape genetic framework employed in this study is broadly applicable to other agricultural pests and might reveal general responses of pests to agricultural land‐use change.
Counties not countries: Variation in host specificity among populations of an aphid parasitoid
Authors: Hopper Keith R. , Oppenheim Sara J. , Kuhn Kristen L. , Lanier Kathryn , Hoelmer Kim A. , Heimpel George E. , Meikle William G. , O’Neil Robert J. , Voegtlin David G. , Wu Kongming , Woolley James B. , Heraty John M. 
Published: December 2018

AbstractParasitic wasps are among the most species‐rich groups on Earth. A major cause of this diversity may be local adaptation to host species. However, little is known about variation in host specificity among populations within parasitoid species. Not only is such knowledge important for understanding host‐driven speciation, but because parasitoids often control pest insects and narrow host ranges are critical for the safety of biological control introductions, understanding variation in specificity and how it arises are crucial applications in evolutionary biology. Here, we report experiments on variation in host specificity among 16 populations of an aphid parasitoid, Aphelinus certus. We addressed several questions about local adaptation: Do parasitoid populations differ in host ranges or in levels of parasitism of aphid species within their host range? Are differences in parasitism among parasitoid populations related to geographical distance, suggesting clinal variation in abundances of aphid species? Or do nearby parasitoid populations differ in host use, as would be expected if differences in aphid abundances, and thus selection, were mosaic? Are differences in parasitism among parasitoid populations related to genetic distances among them? To answer these questions, we measured parasitism of a taxonomically diverse group of aphid species in laboratory experiments. Host range was the same for all the parasitoid populations, but levels of parasitism varied among aphid species, suggesting adaptation to locally abundant aphids. Differences in host specificity did not correlate with geographical distances among parasitoid populations, suggesting that local adaption is mosaic rather than clinal, with a spatial scale of less than 50 kilometers. We sequenced and assembled the genome of A. certus, made reduced‐representation libraries for each population, analyzed for single nucleotide polymorphisms, and used these polymorphisms to estimate genetic differentiation among populations. Differences in host specificity correlated with genetic distances among the parasitoid populations.
The history of urologic pathology: an overview
Authors: Young Robert H , Eble John N 
Published: December 2018

This article begins with the testis and a legendary figure, Sir Astley Cooper, who wrote an early text on the organ. The early 20th century saw the first major development, the description of the seminoma by the French investigator Maurice Chevassu, but the pace of knowledge did not accelerate until after World War II with a major article from the Armed Forces Institute of Pathology (AFIP) by Nathan B. Friedman and Robert A. Moore, soon followed by the first series testis fascicle by Frank J. Dixon and Moore. Other noteworthy contributions were made by two masters of gonadal pathology, Gunnar Teilum and Robert E. Scully. In the 1970s, Niels E. Skakkebaek played a seminal role in elaborating in‐situ neoplasia of the testis. The school of British testicular tumour authored, in the mid‐1970s, under the editorship of Roger C. B. Pugh, one of the best texts on testicular pathology. Advances in more recent years have been largely spearheaded by Thomas M. Ulbright of the Indiana University School of Medicine. Observations on the prostate gland date back to Andreas Vesalius and William Cheselden, the latter appearing to have introduced the word for the gland. Note is made of contributions on the anatomy and histology of the gland by Oswald Lowsley, L. M. Franks, and John McNeal. Diagnosing carcinoma of the prostate was brought into the modern age in a landmark 1953 article by Robert S. Totten et al. In the 1960s, Donald F. Gleason introduced a grading system that is now in use worldwide. The topic of premalignant lesions has been well established only for approximately three decades, based initially on the work of Dr McNeal and David G. Bostwick. One of the first to write a book on the bladder was the remarkable British surgeon‐pathologist Sir Henry Thompson. Workers at the AFIP, including Colonel James E. Ash and Fatallah K. Mostofi, wrote many outstanding articles on bladder pathology. The roles of other institutions, such as Johns Hopkins University, the Mayo Clinic, and St Peter's Hospital Institute of Urology, London, and those who worked there are noted. Knowledge of the pathology of the urachus dates largely back to the remarkable book on the topic in 1916 by the Hopkins investigator Thomas S. Cullen. Information on renal tumours dates largely to the work of Paul Grawitz, but awareness of the many variants of renal cell carcinoma in general was slow to evolve, and has only accelerated in recent years. The AFIP group of Dr Mostofi, ably assisted by Colonel Charles J. Davis and Isabell A. Sesterhenn, has contributed to knowledge of renal neoplasia with articles of note on oncocytoma, metanephric adenoma, and medullary carcinoma. In the mid‐1980s, the German workers Wolfgang Thoenes and Stephan Störkel recognised the distinctive tumour known as chromophobe renal cell carcinoma. Work on renal tumours in the young owes much to J. Bruce Beckwith. The observational talents of numerous investigators have, in just over a century, advanced our knowledge of diseases of the urinary tract and testis remarkably.
The Punitive Nature of Pre‐Trial Detention: Perspectives of Detainees in Hong Kong
Authors: CHENG KEVIN KWOK‐YIN , LEUNG BECKY PO‐YEE 
Published: December 2018

AbstractPre‐trial detention plays an important, and often contentious, role in the criminal justice process. Legal theorists have gone to great lengths to distinguish between preventive detention and punishment with respect to pre‐trial detention, as it would violate the principle of retribution and the presumption of innocence if yet‐to‐be convicted defendants were subjected to punishment. Nonetheless, the experiences of detainees remains an understudied area. The purpose of this article is not to dispute whether pre‐trial detention is, or can be justified as, a form of punishment, but it is to show that pre‐trial detention, at least in the minds of detained defendants, is punitive. Drawing on interviews with a sample of previously‐detained defendants in Hong Kong, it is found that they experience censure (stigma) and hard treatment during their time in pre‐trial detention. Implications and recommendations are discussed.
Nursing research in the Arab Region: A bibliometric analysis
Authors: Dardas Latefa Ali , Sawair Faleh A. , Nabolsi Manar , Simmons Leigh Ann 
Published: December 2018

AbstractAimsScientific discovery in general, and nursing research specifically, is an increasingly global effort consistent with changing demographics and the need to provide culturally competent care in a diverse society. Given that Arabs account for an increasing proportion of the populations in many Western countries, this study presents findings from the first bibliometric analysis of nursing research conducted through December 2017 in the Arab region.MethodsWe used quantitative and qualitative indicators to analyse bibliometric data from Scopus.ResultsWe provided significant data on Arab nursing publication output and growth trends; types of published documents; publication geographic loci, focus, and subject categories; authors' collaboration patterns; core publishing journals and their impact; and citation patterns.ConclusionsOur findings highlighted the need for Arab policy makers and funding agencies to allocate research funding that supports the dissemination of Arab nursing research into the broader scientific community so that Western researchers, policymakers, and health care providers can appropriately address the health care needs of Arab individuals and families. The insights gleaned regarding the performance of journals, authors, countries, and institutions are discussed in relation to the potential impacts of the publish‐or‐perish culture of the current academic world.
MicroRNA miR‐252 targets mbt to control the developmental growth of Drosophila
Authors: Lim D.‐H. , Lee S. , Han J. Y. , Choi M.‐S. , Hong J.‐S. , Lee Y. S. 
Published: December 2018

AbstractDevelopmental growth is an intricate process involving the coordinated regulation of the expression of various genes, and microRNAs (miRNAs) play crucial roles in diverse processes throughout animal development. The ecdysone‐responsive miRNA, miR‐252, is normally upregulated during the pupal and adult stages of Drosophila development. Here, we found that overexpression of miR‐252 in the larval fat body decreased total tissue mass through a reduction in both cell size and cell number, causing a concomitant decrease in larval size. Furthermore, miR‐252 overexpression led to a delayed larval‐to‐pupal transition with defective anterior spiracle eversion, as well as a decrease in adult size and mass. Conversely, adult flies lacking miR‐252 showed an increase in mass compared with control flies. We found that miR‐252 directly targeted mbt, encoding a p21‐activated kinase, to repress its expression. Notably, co‐overexpression of mbt rescued the developmental and growth defects associated with miR‐252 overexpression, indicating that mbt is a biologically relevant target of miR‐252. Overall, our data support a role for the ecdysone/miR‐252/mbt regulatory axis in growth control during Drosophila development.
Newborn screening for severe combined immunodeficiency and T‐cell lymphopenia
Authors: Puck Jennifer M. 
Published: December 2018

SummaryThe development of a T cell receptor excision circle (TREC) assay utilizing dried blood spots (DBS) made possible universal newborn screening (NBS) for severe combined immunodeficiency (SCID) as a public health measure. Upon being flagged by an abnormal screening test in a SCID screening program, an infant can receive further diagnostic testing for SCID in the neonatal period, prior to onset of infectious complications, to permit immediate institution of protective measures and definitive, life‐saving treatment to establish a functional immune system. SCID screening is now the accepted standard of care in state public health departments across the United States, and it is being adopted in many countries. It has proven effective, with infants having this otherwise inapparent but serious, rare disorder achieving survival and immune reconstitution. In addition to bringing to attention infants with the primary screening target diseases, typical SCID and leaky SCID (due to hypomorphic mutations in known SCID genes), the NBS assay for insufficient TRECs in DBS also reveals infants with non‐SCID T lymphopenic conditions. Experience has accumulated regarding the range and limitations of diagnoses of newborns with low TRECs and low T cells. Previously unknown immune defects have been discovered, as well as conditions not formerly recognized to have low T cells in the neonatal period.
Social determinants of health and maxillofacial injuries in children and adolescents victims of violence: A novel GIS‐based modelling application
Authors: de Macedo Bernardino Ítalo , da Nóbrega Lorena Marques , da Silva José Régis Cordeiro , de Alencar Catarina Ribeiro Barros , de Olinda Ricardo Alves , d’Ávila Sérgio 
Published: December 2018

BackgroundPhysical violence against children and adolescents comprises a serious public health problem and often results in oral and maxillofacial traumas. Social determinants may favour the occurrence of these events, but few studies have critically evaluated the interaction between social and geographical risk factors.AimsTo investigate the spatiotemporal distribution of oral and maxillofacial traumas resulting from violence against children and adolescents through geostatistical techniques.MethodsThis study was an ecological analysis of cases of trauma caused by violence against Brazilian children and adolescents using aggregated data from victims attended at a Center of Forensic Medicine and Forensic Dentistry between January 2012 and December 2015. Data were analysed through modelling based on geographic information system (GIS).ResultsTwo distinct patterns of longitudinal trajectory of oral and maxillofacial trauma related to violence against children and adolescents were identified (TP1 and TP2, P < 0.05). The spatial regression analysis revealed a statistically significant association between higher incidence of cases and areas with worse socioeconomic conditions (β = 0.047, SE = 0.020, P < 0.05).ConclusionNeighbourhoods with considerable socio‐spatial vulnerability for violence against children and adolescents and maxillofacial traumas were identified.
Impedance spectroscopy and conduction mechanism of magnetoelectric hexaferrite BaFe10.2Sc1.8O19
Authors: Zhu Qishan , Tang Rujun , Zhou Hao , Wang Yu , Xu Sicheng , Zhang Jianmin , Jiang Changjun , Su Xiaodong , Yang Hao 
Published: December 2018

AbstractThe dielectric relaxation and conduction properties of hexaferrite BaFe10.2Sc1.8O19 (BFSO) ceramics have been investigated by impedance spectroscopy (1 Hz‐2 GHz) at various temperatures (253‐473 K). The frequency dependence of impedance and modulus spectra of BFSO shows that its dielectric responses are thermally activated. The scaling behaviors of impedance spectra indicate that the distribution of dielectric relaxation times in BFSO is temperature independent. The frequency‐dependent conductivity spectra follow the universal‐power‐law at high temperatures but deviate slightly at low temperatures. An enormous increase in relaxation/conduction activation energies of BFSO above 413 K is also observed in both impedance and conductivity spectra. This indicates that at high temperatures, relaxation/conduction processes may be contributed mainly by the movable oxygen vacancies, whereas at low‐temperature electron hopping dominates. The conductivity fitting results further suggest that electron/oxygen vacancy‐related small polaron hopping should be the most probable conduction mechanism for BFSO.
Targeting the lysosome by an aminomethylated Riccardin D triggers DNA damage through cathepsin B‐mediated degradation of BRCA1
Authors: Wang Yanyan , Niu Huanmin , Hu Zhongyi , Zhu Mengyuan , Wang Lining , Han Lili , Qian Lilin , Tian Keli , Yuan Huiqing , Lou Hongxiang 
Published: December 2018

AbstractRD‐N, an aminomethylated derivative of riccardin D, is a lysosomotropic agent that can trigger lysosomal membrane permeabilization followed by cathepsin B (CTSB)‐dependent apoptosis in prostate cancer (PCa) cells, but the underlying mechanisms remain unknown. Here we show that RD‐N treatment drives CTSB translocation from the lysosomes to the nucleus where it promotes DNA damage by suppression of the breast cancer 1 protein (BRCA1). Inhibition of CTSB activity with its specific inhibitors, or by CTSB‐targeting siRNA or CTSB with enzyme‐negative domain attenuated activation of BRCA1 and DNA damage induced by RD‐N. Conversely, CTSB overexpression resulted in inhibition of BRCA1 and sensitized PCa cells to RD‐N‐induced cell death. Furthermore, RD‐N‐induced cell death was exacerbated in BRCA1‐deficient cancer cells. We also demonstrated that CTSB/BRCA1‐dependent DNA damage was critical for RD‐N, but not for etoposide, reinforcing the importance of CTSB/BRCA1 in RD‐N‐mediated cell death. In addition, RD‐N synergistically increased cell sensitivity to cisplatin, and this effect was more evidenced in BRCA1‐deficient cancer cells. This study reveals a novel molecular mechanism that RD‐N promotes CTSB‐dependent DNA damage by the suppression of BRCA1 in PCa cells, leading to the identification of a potential compound that target lysosomes for cancer treatment.
Soil tillage reduces arthropod biodiversity and has lag effects within organic and conventional crop rotations
Authors: Patterson Eli S. P. , Sanderson Roy A. , Eyre Michael D. 
Published: December 2018

AbstractCrop rotation systems in organic and conventional farming systems differ in crop types, management and duration. However, changes in arthropod communities over the entire rotation system are poorly understood, as many studies have surveyed only single years or have not covered the entire rotation period. Here, we describe changes in arthropods in two contrasting systems at a split organic‐conventional farm: an 8‐year organically managed rotation with five crops and a 5‐year conventionally managed rotation with three crops. Arthropods were classified into three functional groups, representing epigeal predators, foliar predators/parasitoids and herbivores/pollinators. Epigeal predators were particularly reduced by soil tillage which occurred annually in the conventional rotation, but was intermittent in the organic. Arthropods were most abundant on the conventional rotation, but most taxonomically diverse on the organic. In the conventional system, all functional groups showed a cyclical change in their taxonomic composition that closely matched the crop rotation sequence, whereas in the organic rotation, the cycle was less clear. Whilst the current year's crop type was the major determinant of arthropod community composition, there was a significant “lag effect” for many taxa from the preceding year's crop. Our results suggest that both the amounts of soil tillage (e.g., in no‐till systems) and crop rotation order have major impacts on arthropods in agroecosystems. Rotations with excessive soil tillage are likely to reduce the abundance of some groups of beneficial arthropods, especially epigeal predators.
Anatomical, microbiological, and genetic considerations in treatment of Chinese periodontal patients
Authors: Goh Edwin X. J. , Ong Marianne M. A. 
Published: December 2018

AbstractThe aim of the present narrative review was to highlight considerations when treating Chinese patients with periodontal diseases. These considerations can be broadly categorized into anatomical, microbiological, and genetic considerations. Anatomical considerations are tooth‐related factors causing site‐specific issues, and these include incisal palatal groove, root concavities, three‐rooted permanent mandibular first molar, furcation entrance dimensions, cervical enamel projections, root trunk length, and molar root fusion. Aggregatibacter actinomycetemcomitans was found to be commensal in the oral flora of Chinese. The association between a single gene polymorphism and periodontal disease has not been unequivocally proven in Chinese populations. Despite these subtle differences compared to other ethnic populations, studies of Chinese participants from various geographic regions have demonstrated that periodontal disease in this particular ethnic group can be successfully treated.