bluuebunny/crossref_metadata_2025_split huggingface dataset:
New composite supernova remnant toward HESS J1844-030?
Authors: Petriella A. 
Published: May 2019

Aims. HESS J1844-030 is a newly confirmed TeV source in the direction of the X-ray pulsar wind nebula (PWN) candidate G29.4+0.1 and the complex radio source G29.37+0.1, which is likely formed by the superposition of a background radio galaxy and a Galactic supernova remnant (SNR). Many scenarios have been proposed to explain the origin of HESS J1844-030, based on several sources that are capable of producing very high energy radiation. We investigate the possible connection between the SNR, the PWN G29.4+0.1, and HESS J1844-030 to shed light on the astrophysical origin of the TeV emission.
Methods. We performed an imaging and spectral study of the X-ray emission from the PWN G29.4+0.1 using archival observations obtained with the Chandra and XMM-Newton telescopes. Public radio continuum and HI data were used to derive distance constraints for the SNR that is linked to G29.37+0.1 and to investigate the interstellar medium where it is expanding. We applied a simple model of the evolution of a PWN inside an SNR to analyze the association between G29.4+0.1 and the radio emission from G29.37+0.1. We compared the spectral properties of the system with the population of TeV PWNe to investigate if HESS J1844-030 is the very high energy counterpart of the X-ray PWN G29.4+0.1.
Results. Based on the morphology and spectral behavior in the X-ray band, we conclude that G29.4+0.1 is a PWN and that a point source embedded on it is the powering pulsar. The HI data revealed that the SNR linked to G29.37+0.1 is a Galactic source at 6.5 kpc and expanding in a nonuniform medium. From the analysis of the pulsar motion and the pressure balance at the boundary of X-ray emission, we conclude that G29.4+0.1 could be a PWN that is located inside its host remnant, forming a new composite SNR. Based on the magnetic field of the PWN obtained from the X-ray luminosity, we found that the population of electrons producing synchrotron radiation in the keV band can also produce IC photons in the TeV band. This suggests that HESS J1844-030 could be the very high energy counterpart of G29.4+0.1.
Recent results from the cosmic ray program of the NA61/SHINE experiment
Authors: Prado Raul R. 
Published: May 2019

NA61/SHINE is a fixed target experiment designed to study hadron-proton, hadron-nucleus and nucleus-nucleus interactions at the CERN Super-Proton-Synchrotron. In this paper we summarize the results from pion-carbon collisions recorded at beam momenta of 158 and 350 GeV=c. Hadron production measurements in these types of interactions is of fundamental importance for the understanding of the muon production in extensive air showers. In particular, production of (anti)baryons and ρ0 are mechanisms responsible for increasing the number of muons which reach the ground. The underestimation of the (anti)baryons or ρ0 production rates in current hadronic interaction models could be one of the sources of the excess of muons observed by cosmic ray experiments. The results on the production spectra of π±, K±, p, ¯p, Λ	, ¯Λ, K0S, ρ0, ω and K*0 are presented, as well as their comparison to predictions of hadronic interaction models currently used in air shower simulations.
Performance measures for small-bowel endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative
Authors: Spada Cristiano , McNamara Deirdre , Despott Edward J. , Adler Samuel , Cash Brooks D. , Fernández-Urién Ignacio , Ivekovic Hrvoje , Keuchel Martin , McAlindon Mark , Saurin Jean-Christophe , Panter Simon , Bellisario Cristina , Minozzi Silvia , Senore Carlo , Bennett Cathy , Bretthauer Michael , Dinis-Ribeiro Mario , Domagk Dirk , Hassan Cesare , Kaminski Michal F. , Rees Colin J. , Valori Roland , Bisschops Raf , Rutter Matthew D. 
Published: May 2019

AbstractThe European Society of Gastrointestinal Endoscopy (ESGE) together with the United European Gastroenterology (UEG) recently developed a short list of performance measures for small-bowel endoscopy (i. e. small-bowel capsule endoscopy and device-assisted enteroscopy) with the final goal of providing endoscopy services across Europe with a tool for quality improvement. Six key performance measures for both small-bowel capsule endoscopy and for device-assisted enteroscopy were selected for inclusion, with the intention being that practice at both a service and endoscopist level should be evaluated against them. Other performance measures were considered to be less relevant, based on an assessment of their overall importance, scientific acceptability, and feasibility. Unlike lower and upper gastrointestinal endoscopy, where performance measures had already been identified, this is the first time that small-bowel endoscopy quality measures have been proposed.
Interobserver Agreement of Planar and SPECT Tc99m-MIBI Scintigraphy for the Assessment of Hypofunctioning Thyroid Nodules
Authors: Schenke Simone , Klett Rigobert , Acker Peter , Rink Thomas , Kreissl Michael C , Zimny Michael 
Published: May 2019

Abstract
Introduction Thyroid scintigraphy with 99mTc-methoxyisobutylisonitrile (MIBI) is a helpful tool for the risk stratification of thyroid nodules (TN). Whereas a nodule with low or hypointense MIBI uptake has a low risk for malignancy, a hyperintense uptake may indicate a malignant nodule, which requires surgical resection. The appropriate diagnostic or therapeutic regimen of an isointense nodule with an uptake similar to the paranodular tissue is discussed controversially. Aim of this study was to assess the interobserver agreement (IA) for the assignment of TN to the three categories: hypo-, iso-or hyperintense.
Methods Retrospective analysis of planar and SPECT images of MIBI scintigraphy was performed in 36 randomly selected patients with hypofunctioning TN and histological diagnosis. Four observers with different levels of experience in MIBI-scintigraphy analyzed MIBI uptake and assigned the nodules to the appropriate category. To assess the IA, Fleiss‘ Kappa was calculated.
Results The study cohort included 11 patients with papillary thyroid carcinoma (diameter 20.3 mm) and 25 patients with benign nodules (diameter 24.8 mm). The IA for all nodules using planar images was 0.76 compared to 0.80 for SPECT images. The IA was better in the subgroup of malignant nodules for planar images as well as SPECT images (Kappa 0.91 and 0.90, respectively) compared to benign nodules (0.65 and 0.76, respectively). Using SPECT images, only one thyroid carcinoma presented with hypointense uptake, the remainder with hyper- or isointense uptake. In contrast, benign nodules were found in all categories.
Conclusion MIBI scintigraphy shows a good IA for the interpretation of thyroid carcinoma. The IA is further improved if MIBI scintigraphy is performed in SPECT technique.
Prevalence of Dyslipidaemia and Pre-Diabetes Among Women with Polycystic Ovary Syndrome (PCOS): Do We Overestimate Cardiovascular Risk?
Authors: Lewandowski Krzysztof C. , Płusajska Justyna , Horzelski Wojciech , Lewiński Andrzej 
Published: May 2019

AbstractPCOS is widely accepted as associated with an increased cardiovascular risk, however, without convincing evidence of an increased cardiovascular mortality. We assessed prevalence of obesity, glucose intolerance, and dyslipidaemia in 490 women with PCOS, aged 24.75±8.05 years, diagnosed according to the Rotterdam consensus criteria. Fifty-two percent of women had BMI<26 kg/m2, 81.8% had total cholesterol<200 mg/dl, 82.8% had LDL cholesterol<130 mg/dl (48.3%<100 mg/dl), 81.4% had triglycerides<150 mg/dl, 96.08% had fasting glucose<100 mg/dl, 90.3% had glucose<140 mg/dl at 120′ of OGTT. The most frequent abnormality was low HDL cholesterol, as only 33.9% had LDL>60 mg/dl. Combination of several risk factors related to dyslipidaemia was, however, relatively rare, for example, a combination of raised total cholesterol and LDL cholesterol was present only in 2.9% of subjects. An increase in BMI, total cholesterol, LDL-cholesterol, and glucose concentrations at 120′ of OGTT was more pronounced in women, who had raised concentrations of at least two androgens (n=172, 35.1%), yet there was no increase in insulin resistance parameters, that is, HOMA-IR, QUICKI, McAuley, or Belfiore index. Contrary to common belief, over 50% of women with PCOS have normal body weight, and with exception of lower HDL cholesterol, most have no significant dyslipidaemia or glucose intolerance. Women with normal or borderline abnormal androgens, who form the majority of PCOS subjects, seem to have more healthy metabolic profile. This might be one of the reasons for the absence of evidence of an increased CV mortality in women with PCOS.
Massive Brain Swelling after Cranioplasty: A Case Report
Authors: Zhang Xiaoyang , Pan Baogen , Ye Zhanying , Li Zheng , Mo Feng , Wang Xiaoyan 
Published: May 2019

Abstract
Background Cranioplasty is a common procedure in neurosurgery. It is usually performed following decompressive craniectomy (DC). However, complications may occur after the operation, such as massive brain swelling. Up to now, far too little attention has been given to this severe complication. We report one case of fatal cerebral swelling after cranioplasty and analyze the possible mechanism of this complication.
Case Description The patient was a 40-year-old man who had a severe right basal ganglia cerebral hemorrhage and underwent DC ∼ 2 months before. One day before scheduled cranioplasty, a lumbar cerebrospinal fluid drainage was placed. The cranioplasty itself was uneventful. However, he gradually fell into a coma, and his right pupil was moderately dilated 20 hours after the surgery. A brain computed tomography (CT) scan indicated massive right cerebral edema with compressed right midbrain. The patient did not regain consciousness, and he remained quadriplegic.
Conclusion It is necessary to increase awareness of complications of cranioplasty in high-risk patients. The lessons learned from this case include avoiding excessive drainage of cerebrospinal fluid. Patients with low-density lesions in the brain need to be treated with caution. Once the CT scan shows massive cerebral swelling, the patient has a poor prognosis.
Acute and chronic effects of competition on ankle dorsiflexion ROM in professional football players
Authors: Moreno‐Pérez Victor , Soler Aitor , Ansa Asier , López‐Samanes Álvaro , Madruga‐Parera Marc , Beato Marco , Romero‐Rodríguez Daniel 
Published: May 2019

ABSTRACTThe aim of this study was to investigate the acute (a football match) and chronic (a whole season) effects of competition on ankle dorsiflexion ROM in professional football players. Forty football players participated in this study. Ankle dorsiflexion ROM was recorded to examine acute (pre‐match, immediately post‐match and 48 h post‐match) and chronic (pre‐season, mid‐season and post‐season) effects of competitive football. In addition, it was found that players had restricted mobility measures on ankle dorsiflexion as >2 cm change between baseline measures (pre‐match and pre‐season). The training load of all played matches was estimated using a global positioning system (GPS) and RPE. Pre‐season ankle dorsiflexion ROM was greater compared to mid‐season (8.1% in the dominant, and 9.6% in the non‐dominant leg) and post‐season (13.8% in the dominant, and 12.5% in the non‐dominant leg). In addition, around 30% of all players showed restricted ankle dorsiflexion ROM values in post‐season compared with pre‐season. Related to acute effects, ankle dorsiflexion ROM increased after a match (5.8%) in the dominant ankle, and this value decreased (2.65%) 48 h post‐match when post‐match measurements in both dominant and non‐dominant ankles were compared. The progressive decrease in ankle dorsiflexion ROM throughout a season can be an indicator of increased risk of injury and may be reinforce the need of prevention actions such as stretching exercises and eccentric strength training in professional football players. In addition, these findings suggest to implement specific recovery strategies aiming at minimizing alteration in ankle dorsiflexion ROM 48 h post‐match.
Design and commissioning of an image-guided small animal radiation platform and quality assurance protocol for integrated proton and x-ray radiobiology research
Authors: Kim Michele M , Irmen Peyton , Shoniyozov Khayrullo , Verginadis Ioannis I , Cengel Keith A , Koumenis Costantinos , Metz James M , Dong Lei , Diffenderfer Eric S 
Published: May 2019

Abstract
Small animal x-ray irradiation platforms are expanding the capabilities and future pathways for radiobiology research. Meanwhile, proton radiotherapy is transitioning to a standard treatment modality in the clinician’s precision radiotherapy toolbox, highlighting a gap between state-of-the-art clinical radiotherapy and small animal radiobiology research. Comparative research of the biological differences between proton and x-ray beams could benefit from an integrated small animal irradiation system for in vivo experiments and corresponding quality assurance (QA) protocols to ensure rigor and reproducibility. The objective of this study is to incorporate a proton beam into a small animal radiotherapy platform while implementing QA modelled after clinical protocols.
A 225 kV x-ray small animal radiation research platform (SARRP) was installed on rails to align with a modified proton experimental beamline from a 230 MeV cyclotron-based clinical system. Collimated spread out Bragg peaks (SOBP) were produced with beam parameters compatible with small animal irradiation. Proton beam characteristics were measured and alignment reproducibility with the x-ray system isocenter was evaluated. A QA protocol was designed to ensure consistent proton beam quality and alignment. As a preliminary study, cellular damage via γ-H2AX immunofluorescence staining in an irradiated mouse tumor model was used to verify the beam range in vivo.
The beam line was commissioned to deliver Bragg peaks with range 4–30 mm in water at 2 Gy min−1. SOBPs were delivered with width up to 25 mm. Proton beam alignment with the x-ray system agreed within 0.5 mm. A QA phantom was created to ensure reproducible alignment of the platform and verify beam delivery. γ-H2AX staining verified expected proton range in vivo.
An image-guided small animal proton/x-ray research system was developed to enable in vivo investigations of radiobiological effects of proton beams, comparative studies between proton and x-ray beams, and investigations into novel proton treatment methods.
Pairing, waltzing and scattering of chemotactic active colloids
Authors: Saha Suropriya , Ramaswamy Sriram , Golestanian Ramin 
Published: May 2019

Abstract
We study theoretically an active colloid whose polar axis of self-propulsion rotates to point parallel (antiparallel) to an imposed chemical gradient. We show that the coupling of this ‘chemotactic’ (‘antichemotactic’) response to phoretic translational motion yields remarkable two-particle dynamics reflecting the non-central and non-reciprocal character of the interaction. A pair of mutually chemotactic colloids trap each other in a final state of fixed separation resulting in a self-propelled active dimer. A second type of bound state is observed when the polar axes undergo periodic cycles leading to phase-locked circular motion around a common centre. A pair of swimmers with mismatched phoretic mobilities execute a dance in which they twirl around one another while moving jointly in a wide circle. For sufficiently small initial separation, the speed of self-propulsion controls the transition from bound to scattering states. Mutually anti-chemotactic swimmers always scatter apart. For the special case in which one of the two colloids has uniform surface activity we succeed in exactly classifying the fixed points underlying the bound states, and identify the bifurcations leading to transitions from one type of bound state to another. The varied dynamical behaviours are accessible by tuning the swimmer design and are summarised in state diagrams.
Flexible Modeling of the Association Between Cumulative Exposure to Low-Dose Ionizing Radiation From Cardiac Procedures and Risk of Cancer in Adults With Congenital Heart Disease
Authors: Danieli Coraline , Cohen Sarah , Liu Aihua , Pilote Louise , Guo Liming , Beauchamp Marie-Eve , Marelli Ariane J , Abrahamowicz Michal 
Published: May 2019

AbstractAdults with congenital heart disease are increasingly being exposed to low-dose ionizing radiation (LDIR) from cardiac procedures. In a recent study, Cohen et al. (Circulation. 2018;137(13):1334–1345) reported an association between increased LDIR exposure and cancer incidence but did not explore temporal relationships. Yet, the impact of past exposures probably accumulates over years, and its strength may depend on the amount of time elapsed since exposure. Furthermore, LDIR procedures performed shortly before a cancer diagnosis may have been ordered because of early symptoms of cancer, raising concerns about reversal causality bias. To address these challenges, we combined flexible modeling of cumulative exposures with competing-risks methodology to estimate separate associations of time-varying LDIR exposure with cancer incidence and all-cause mortality. Among 24,833 patients from the Quebec Congenital Heart Disease Database, 602 had incident cancer and 500 died during a follow-up period of up to 15 years (1995–2010). Initial results suggested a strong association of cancer incidence with very recent LDIR exposures, likely reflecting reverse causality bias. When exposure was lagged by 2 years, an increased cumulative LDIR dose from the previous 2–6 years was associated with increased cancer incidence, with a stronger association for women. These results illustrate the importance of accurate modeling of temporal relationships between time-varying exposures and health outcomes.
Endemism and diversity in European montane mammals: macro-ecological patterns
Authors: Amori Giovanni , Boitani Luigi , Milana Giuliano , Maiorano Luigi , Luiselli Luca 
Published: May 2019

AbstractMountains are important landforms with regard to both biodiversity and evolution of endemism. We analysed macro-ecological patterns of distribution and endemism of European montane (i.e. with at least 70% of their range inside mountain areas) mammals. The landscape of the study area was characterized by three environmental variables: land cover, land-use and elevation. For each species, we collected spatially explicit information on the extent of occurrence, level of endemicity, conservation status, habitat preferences, elevation range and all the available presence points. Montane species accounted for 25.5% of the total (N = 66), whereas lowland species (N = 193) accounted for 74.5% of the total European mammals. There was a significantly lower mean range in size of montane species compared to non-montane species. There was a negative correlation between the number of species and elevation, and a negative correlation between median elevation of the range of a given species and its extent of occurrence. The highest peak in the percentage of species present in each altitudinal band was observed at lower elevations in the lower altitude mountain chains. There was a significantly negative correlation between elevation and Simpson’s index of habitats, but species richness increased significantly with Simpson’s index of habitat diversity. A total of 122 species (40.7%) were European endemics, with the frequencies of endemic species not being different between montane areas and overall. A logistic regression model showed that, for a given species, being montane also enhanced the probability of being endemic to Europe. Montane species are especially concentrated in the Caucasus, along the Turkish coast of the Black Sea. The area of the various mountain chains did not influence either the number of montane species or the number of montane species that are strictly endemic to that mountain chain. A total of 45 endemic montane species were recorded for the study region, with only ten being of conservation concern according to IUCN criteria.
Pathologic up-regulation of TNFSF15–TNFRSF25 axis sustains endothelial dysfunction in unprovoked venous thromboembolism
Authors: Della Bella Silvia , Calcaterra Francesca , Bacci Monica , Carenza Claudia , Pandolfo Chiara , Ferrazzi Paola , Uva Paolo , Pagani Massimiliano , Lodigiani Corrado , Mavilio Domenico 
Published: May 2019

Abstract

Aims
The pathogenetic mechanisms underlying unprovoked venous thromboembolism (uVTE) are largely unknown. In this study, we investigated the molecular mechanisms involved in uVTE pathogenesis by using ex vivo expanded endothelial colony-forming cells (ECFCs), which represent a valuable non-invasive tool for the assessment of endothelial function.

Methods and results
We isolated and expanded ECFCs from the peripheral blood of uVTE patients and observed that these cells underwent earlier senescence and showed lower growth rate compared with ECFCs obtained from healthy donors. Through microarray expression profiling, we demonstrated that 2905 genes were differentially expressed between patients and controls. Among them, the anti-angiogenic cytokine TNF superfamily member 15 (TNFSF15) and its death-receptor TNFRSF25 were up-regulated in uVTE ECFCs, and this finding was validated by RT-qPCR. TNFSF15 up-regulation was confirmed at the protein level in ECFC supernatants, and the in vivo relevance of these findings was further corroborated by demonstrating that also the plasmatic levels of TNFSF15 are increased in uVTE patients. After proving that exogenous TNFSF15 exerts pro-apoptotic and anti-proliferative activity on control ECFCs, we demonstrated through blocking experiments that TNFSF15 up-regulation contributes to impaired survival and proliferation of uVTE ECFCs.

Conclusion
By providing evidence that TNFSF15 impairs ECFC functions crucial to endothelial repair, and that uVTE patients have increased TNFSF15 levels both ex vivo and in vivo, the results of this study suggest that pathologic up-regulation of TNFSF15–TNFRSF25 axis may contribute to uVTE pathogenesis, and may represent the target for novel therapeutic strategies aimed at preventing recurrences in uVTE patients.