bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the clinical benefits for non-small cell lung cancer patients between different volume of pleural lavage fluid following video-assisted thoracoscopic lobectomy and systematic mediastinal lymph node dissection: study protocol for a randomized controlled trial
Authors: Zhou Jian , Liu Chengwu , Man Shulei , Lyu Mengyuan , Liao Hu , Chen Nan , Cheng Yuhui , Liu Lunxu 
Published: June 2019

Abstract
Background: Pleural lavage is regularly performed before closing the chest wall in pulmonary surgery to prevent pleural implantation of tumor cells and postoperative infection. However, no proper regimen of pleural lavage is available now. To establish a reliable procedure of pleural lavage, we designed this prospective, randomized controlled, single-center clinical trial. Methods: A total of 400 participants with the diagnosis of non-small cell lung cancer (NSCLC) undergoing video-assisted thoracoscopic surgery (VATS) lobectomy and systematic mediastinal lymph node dissection (MLND) will be randomly assigned into 2 groups: Group A (500ml pleural lavage fluid) and Group B (3000ml pleural lavage fluid). The primary outcomes include the plasma levels of leukocytes, neutrophils, inflammatory factors, and the incidence of postoperative fever. The secondary outcomes are as follows: volumes of thoracic drainage and total drainage 1 day, 2 days, 3 days after operation; drainage time; postoperative hospitalization; perioperative complications; the incidence of pleural effusion requiring thoracic puncture or drainage within 30 days after surgery. The main content of the analysis is effectiveness and safety analysis. And we will perform subgroup analysis to identify potential influence factors. Discussion: This first randomized controlled trial was expected to compare the clinical outcomes between different volume of pleural lavage fluid following VATS and MLND, and provide us evidence to develop a standardized procedure of pleural lavage before closing thoracic cavity in lung cancer operation. Trial registration number: This study has been registered with the Chinese Clinical Trial Registry (ChiCTR 1900021950) on 17 March 2019. The URL of the trial registry record is http://www.chictr.org.cn/listbycreater.aspx.
Music to improve sleep quality in adults with depression related insomnia (MUSTAFI): Study protocol for a randomized controlled trial
Authors: Lund Helle Nystrup , Pedersen Inge Nygaard , Johnsen Søren Paaske , Heymann-Szlachcinska Agnieszka Maria , Tuszewska Maryla , Bizik Gustav , Larsen Jens Ivar , Kulhay Eszter , Larsen Anelia , Grønbech Bettina Ellen , Østermark Helle , Borup Heidi , Valentin Jan Brink , Mainz Jan 
Published: June 2019

Abstract
Background Insomnia is a common sleep disorder for adults with depression with major impact on the quality of life. Previous trials suggest that music listening may be helpful in the treatment of sleep disturbances in healthy populations including students and elderly. In addition, small studies with clinical populations of traumatized refugees, adults with chronic insomnia and adults with depression insomnia add to the evidence base. However, the impact of music listening in the treatment of depression related insomnia is not well documented. Objective To examine the efficacy of music listening on sleep quality, symptoms of depression and quality of life in adults with depression related insomnia. Method A single center randomized controlled trial (RCT) in a two arm parallel group design is conducted and reported according to the Consort guidelines. The trial consists of an experimental group and a standard care control group. Both groups receive standard treatment for depression following Danish guidelines in an outpatient unit in psychiatry. The experimental group listen to music minimum 30 minutes at bedtime in four weeks. Discussion This study will provide information on the efficacy of music intervention as a non-pharmacological intervention in the treatment of depression related insomnia. This study will provide novel knowledge concerning music medicine as an evidence based treatment of depression in psychiatry. Trial Registration: Clinicaltrials.gov. ID NCT03676491, registered on 19th of September 2018.
Indirect impact of violent events on Emergency Department utilization and disease patterns
Authors: Hitti Eveline , Makhlouf-Obermeyer Carla , Sharara Eman 
Published: June 2019

Abstract
Background

The health effects of war and armed conflict on casualties and mental health of those directly exposed has been well described, but few studies have explored the indirect health effects of violent events. This paper assesses the indirect health impact of several violent events that took place in Beirut in 2013-2014 on ED visit utilization and disease patterns.

Methods

As tracked by media reports, there were 9 violent events in Beirut during 2013-2014. We compared visits to the Emergency Department of a major medical center during weeks when violent events happened and weeks without such events (the preceding week and the same week in preceding years). After re-coding de-identified data from the medical records of 23,067 patients, we assessed differences in the volume of visits, severity index, and discharge diagnoses. Individual control charts were used to analyze ED visit trends post-event.

Results

Comparisons of weeks with violent events and weeks without such events indicate that the socio-demographic characteristics of patients who visited the Emergency Department were similar. Patients seen during violent weeks were significantly more likely to be admitted to the hospital, and to have a lower emergency severity index, indicating greater acuity of their conditions. The discharge diagnoses that were significantly higher during violent event weeks included anxiety disorders, sprains, and gastritis. Daily ED visits dropped post events.

Conclusions

The results indicate that violent events such as bombs, explosions, and terrorist attacks reverberate through the population, impact patterns of ED utilization immediately post-event and are associated with adverse health outcomes, even among those who are not directly affected by the events.
The Effect of Single High-dose Buprenorphine on Opioid Craving and Relapse
Authors: Ahmadi Jamshid , SefidfardJahromi Mina , Ghahremani Dara , London Edythe D. 
Published: June 2019

Abstract
Background: Buprenorphine, a treatment for Opioid Use Disorder, has liability for diversion and abuse. Use of single high doses of buprenorphine that are supervised avoid issues with diversion that occur with unsupervised or take home doses. Such doses have the potential to act as an initial opioid detox, facilitate transition to opioid antagonists or drug free treatments, as well as to maintenance treatment. Objective: To assess effects of a single, physician-administered high dose of buprenorphine on craving and on early relapse. Method: Sixty men who used heroin, opium or prescription opioids and met DSM-5 criteria for Opioid Use Disorder received a single, sublingual dose of buprenorphine (32 mg, 64 mg or 96 mg; n’s = 20, 21, and 19) as inpatients on a psychiatric unit. Buprenorphine was administered when patients were in moderate opioid withdrawal (4-5 symptoms). Self-reports of craving were taken at baseline and daily for the next 13 days, and relapse was assessed 1 and 2 months. Findings: Craving was reduced from baseline in each of the three groups (p < 0.0005), but the doseXtime interaction did not reach statistical significance (p= 0.069). Follow-up assessments at 1- and 2-months indicated significantly lower relapse rates for the higher-dose groups than for the low-dose group (p < 0.05). Conclusions: A single high dose of buprenorphine provides rapid relief of opioid craving and positively impacts relapse rate in the initial 1- and 2-months of outpatient treatment. Further investigation of single high-dose buprenorphine for early treatment of patients with Opioid Use Disorder is warranted as an alternative when buprenorphine/naloxone or long-acting buprenorphine dosage forms are not available.
A mutation in the filamin c gene causes myofibrillar myopathy with lower motor neuron syndrome: a case report
Authors: Chen Juanjuan , Wu Jun , Han ChunXi , Li Yao , Guo Yuzu , Tong Xiaoxin 
Published: June 2019

Abstract
Background: Myofibrillar myopathies (MFMs) are a genetically heterogeneous group of muscle disorders. Mutations in the filamin C gene (FLNC) have previously been identified in patients with MFM. The phenotypes of FLNC-related MFM are heterogeneous. Case presentation: The patient was a 37-year-old male who first experienced weakness in the distal muscles of his hand, which eventually spread to the lower limbs and proximal muscles. Serum creatine kinase levels were moderately elevated. Obvious neuropathic changes in the electromyographic exam and edema changes in lower distal limb magnetic resonance imaging were observed. Histopathological examination revealed the presence of abnormal protein aggregates and angular atrophy in some muscle fibers. Ultrastructural analysis showed inordinate myofibrillar structures and dissolved myofilaments. DNA sequencing analysis detected a heterozygous missense mutation (c.7123G>A, p.V2375I) in the immunoglobulin (Ig)-like domain 21 of FLNC. Conclusions: FLNC mutation c.7123G>A, p.V2375I in the immunoglobulin (Ig)-like domain 21 can be associated with distal myopathy with typical MFM features and lower motor neuron syndrome. Although electromyographic examination of our patient showed obvious neuropathic changes, MFM could not be excluded. Therefore, genetic testing is necessary to make an accurate diagnosis.
Transcriptional characterisation of the Exaiptasia pallida pedal disc
Authors: Davey Peter A , Clarke Jessica L , Rodrigues Marcelo , Aldred Nick 
Published: June 2019

Abstract
Background
Biological adhesion (bioadhesion), enables organisms to attach to surfaces as well as to a range of other targets. Bioadhesion evolved numerous times independently and is ubiquitous throughout the kingdoms of life. To date, investigations have focussed on various taxa of animals, plants and bacteria, but the fundamental processes underlying bioadhesion and the degree of conservation in different biological systems remain poorly understood. This study had two aims: 1) To characterise tissue-specific gene regulation in the pedal disc of the model cnidarian Exaiptasia pallida, and 2) to elucidate putative genes involved in pedal disc adhesion.

Results
Five hundred and forty-seven genes were differentially expressed in the pedal disc compared to the rest of the animal. Four hundred and twenty-seven genes were significantly upregulated and one hundred and twenty genes were significantly downregulated. Forty-one condensed gene ontology terms and 19 protein superfamily classifications were enriched in the pedal disc. Eight condensed gene ontology terms and 11 protein superfamily classifications were depleted. Enriched superfamilies were consistent with classifications identified previously as important for the bioadhesion of unrelated marine invertebrates. A host of genes involved in regulation of extra cellular matrix generation and degradation were identified, as well as others related to development and immunity. Ab initio prediction identified 173 upregulated genes that putatively code for extracellularly secreted proteins.

Conclusion
The analytical workflow facilitated identification of genes putatively involved in adhesion, immunity, defence and development of the E. pallida pedal disc. When defence, immunity and development-related genes were identified, those remaining corresponded most closely to formation of the extracellular matrix (ECM), implicating ECM in the adhesion of anemones to surfaces. This study therefore provides a valuable high-throughput resource for the bioadhesion community and lays a foundation for further targeted research to elucidate bioadhesion in the Cnidaria.
Identifying the Structural Features of Diphenyl Ether Analogues for InhA Inhibition: A 2D and 3D QSAR Based Study
Authors: Tiwari Ashutosh Prasad , Giliyar Varadaraj Bhat , Shenoy Gurypur Gautham , Eshwara Vandana Kalwaja 
Published: June 2019

Background:
Enoyl acyl carrier protein reductase (InhA) is a validated target for
Mycobacterium. It is an enzyme which is associated with the biosynthesis of mycolic acids in type II
fatty acid synthase system. Mycobacterial cell wall majorly comprises mycolic acids, which are
responsible for virulence of the microorganism. Several diphenyl ether derivatives have been known
to be direct inhibitors of InhA.

Objective:
In the present work, a Quantitative Structure Activity Relationship (QSAR) study was
performed to identify the structural features of diphenyl ether analogues which contribute to InhA
inhibitory activity in a favourable way.

Method:
Both 2D and 3D QSAR models were built and compared. Several fingerprint based 2D
QSAR models were generated and their relationship with the structural features was studied. Models
which corroborated the inhibitory activity of the molecules with their structural features were
selected and studied in detail.

Results:
A 2D-QSAR model, with dendritic fingerprints having regression coefficient, for test set
molecules Q2 =0.8132 and for the training set molecules, R2 =0.9607 was obtained. Additionally, an
atom-based 3D-QSAR model with Q2 =0.7697 and R2 =0.9159 was also constructed.

Conclusion:
The data reported by various models provides guidance for the designing of structurally
new diphenyl ether inhibitors with potential activity against InhA of M. tuberculosis.
3D-QSAR Studies on 4,5-Dihydro-1H-pyrazolo [4,3-h] Quinazolines as Plk-1, CDK2/A and Aur-A Serine/Threonine Kinase Inhibitors
Authors: Bhongade Bhoomendra A. , Amnerkar Nikhil D. , Gadad Andanappa K. 
Published: June 2019

Background:
The family of serine/threonine protein kinases is associated with peculiar
tumor cell-cycle checkpoints which are overexpressed in proliferating tissues as well as in cancers,
making them as potential targets for cancer chemotherapy. In the present paper, 3D-QSAR studies
were carried out on 4,5-dihydro-1H-pyrazolo[4,3-h]quinazolines against serine/threonine protein
kinases viz. polo-like 1 (Plk-1), cyclin dependent 2/A (CDK2/A) and Aurora-A (Aur-A) and their in
vitro anti-proliferative activity on A2780 ovarian cancer cell line.

Methods:
3D-QSAR models were derived using stepwise forward-backward partial least square
(SWFB_PLS) regression method using VlifeMDS QSAR plus software and the docking calculations
were carried out using Docking Server.

Results:
The derived statistically significant and predictive 3D-QSAR models exhibited correlation
coefficient r2 in the range of 0.875 to 0.966 and predictive r2 in the range of 0.492 to 0.618. The hydrogen
bond donor NH group joining the phenyl ring with quinazoline and terminal amide group
were found to favored for Plk-1, CDK2/A and anti-proliferative activity. Estimated energy of binding
of compound 45 with enzymes was in the range of -8.52 to -9.03.

Conclusion:
The results of 3D-QSAR studies may be useful in the development of new pyrazolo[
4,3-h]quinazoline derivatives with better inhibitory activities against serine/threonine kinases.
Polymeric Nanoparticles: A Promising Tool to Enhance the Solubility of Poorly Water Soluble Drug
Authors: Kasekar Nirmal M. , Singh Sarabjit , Jadhav K.R. , Kadam V.J. 
Published: June 2019

Objective:
The objective of this study was to entrap water-insoluble drug itraconazole
into polymer to form drug entrapped nanoparticles by using simple formulation strategy and characterize
them for various in vitro properties.

Method:
Itraconazole (ITZ) encapsulated Eudragit E 100 nanoparticles (IEENs) were formulated by
emulsification solvent evaporation technique.

Results:
Developed IEENs were evaluated for entrapment efficiency, particle size, polydispersity
index, and drug release profile. It was clear that drug polymer ratio along with homogenization
speed are the factors affecting droplet size of an emulsion. Evaluation was done by HPLC at
263nm. DSC, XRD studies were carried out. The in vitro antifungal study of nanoparticles suggested
that they are more effective in inhibiting growth of Candida albicans.

Conclusion:
The results from this study suggest the potential use of IEENs to provide a possible
way of improving solubility and thus oral absorption of Itraconazole. Thus the study concluded that
IEENs have potential to effectively treat the fungal infection.
The Usefulness of Serum Sorbitol and Vascular Endothelial Growth Factor A in Predicting Diabetic Retinopathy as Compared to Optical Coherence Tomography
Authors: Hama Almandlawi Sanaa Gadbaan , Mawlood Muhanad Salah 
Published: June 2019

Background:
No specific and sufficient diagnostic biomarkers are currently available for predicting diabetic retinopathy (DR).

Objectives:
This study was conducted to investigate the validity of serum sorbitol and Vascular Endothelial Growth Factor A (VEGF-A) in diagnosing DR and differentiating it from diabetes without retinopathy (DNR). The study also investigated the diagnostic efficiency of these biomarkers when compared to optical coherence tomography OCT.

Methods:
A cross-sectional study included 164 diabetes mellitus patients: 30 patients with no retinopathy (the control group), 86 patients with non-proliferative diabetic retinopathy (NPDR), and 48 patients with Proliferative Diabetic Retinopathy (PDR). Patients were referred to the Layla Qasim Diabetic Center between November 2016 and October 2017 and an ophthalmologist established a DR diagnosis using OCT. Serum sorbitol and serum VEGF-A were measured for all patients.

Results:
By using study biomarkers, the cut-off values of VEGF-A (124.7 ng/ml) and sorbitol (0.3112 mg/ml) were established, and their validity parameters. For sorbitol, the values were as follows: specificity was 75.4, the sensitivity was 80 and 68.3% of observed agreement with the results of the OCT technique. For VEGF-A, the specificity was 73.1 the sensitivity was 80 and 76.2% of the observed agreement. The combined parallel test was applied as negative if both the tests were negative or as positive if either of the tests was positive: a highly significant statistical agreement (Kappa test p <0.001) was found with the gold standard diagnosis (OCT), with 85.4% of observed agreement.

Conclusion:
A combination of serum sorbitol and VEGF-A for diagnosing DR and for differentiating DR from DNR patients exhibits a significant agreement with an OCT diagnosis.
O mito da ausência de preconceito racial na educação infantil no Brasil
Authors: Marques Circe Mara , Dornelles Leni Vieira 
Published: June 2019

Este artigo trata do preconceito racial na Educação Infantil. Resultou de uma pesquisa qualitativa, realizada em escolas infantis da região metropolitana de Porto Alegre, em 2013. Teve o propósito de investigar o modo como as culturas africanas são apresentadas às crianças de 0-3 anos no sentido de implantar o Art. 7º, inciso V, das Diretrizes CurricularesNacionais para a Educação Infantil (DCNEI). Segundo esse documento, as propostas pedagógicas devem estar comprometidas com o rompimento das relações de dominação diversas, inclusive étnico-racial. A coleta de dados ocorreu através de observações e conversas com gestores e professores que atuam em escolas infantis. Os resultados mostraram que a maioria dos profissionais desconhece as DCNEI. Estes afirmaram que nãoocorrem problemas raciais na Educação Infantil e justificaram que as crianças de 0-3 anos são pequenas e não percebem tais diferenças. Praticamente, não há materiais didáticos e imagens de pessoas negras nos espaços das escolas pesquisadas. É preciso não só dar visibilidade às crianças de 0-3 anos como também desconstruir o mito da ausência de preconceito racial para que as histórias e culturas africanas adentrem nos tempos e espaços destas escolas.
Palavras-chave: Educação Infantil; Diretrizes CurricularesNacionais para a Educação Infantil; Preconceito racial
O Exílio dos Professores Brasileiros em Portugal e a Documentação da DOPS-PR
Authors: Braggio Ana Karine , Fiuza Alexandre Felipe 
Published: June 2019

Este artigo almeja analisar a experiência vivida por professores brasileiros que se exilaram para garantir sua sobrevivência, ameaçada por perseguições ocorridas no período da ditadura civil-militar brasileira (1964-1985). Nosso enfoque se direciona aos indivíduos citados nos dossiês temáticos do acervo da Delegacia de Ordem Política e Social do Estado do Paraná (DOPS/PR) e que se exilaram em Portugal. Entre os 2.378 dossiês da DOPS/PR catalogados, analisamos os oito dossiês que tratam especificamente do exílio de brasileiros. Nestes materiais, rastreamos os nomes dos exilados que foram professores no Brasil e/ou que atuaram na docência em Portugal. Nosso objetivo é apresentar, como uma parte da história do exílio, a história de alguns destes professores, que, apesar das dificuldades de adaptação a uma nova cultura e de vivência em novos espaços sociais e políticos, afastados de amigos e familiares, assumiram relevo na consolidação e circulação de novos ideais no plano político-ideológico. Contribuíram ainda para o desenvolvimento pedagógico, utilizando como referência, ainda que esporádica, a Pedagogia Libertadora do movimento educacional crítico e emancipatório sob influência de Paulo Freire, que, por sua militância política incompatível com os anseios do governo ditatorial, também vivenciou a experiência do exílio.
Palavras-Chave: Exílio; Militância; Docência; Ditadura.
Escala de Atribuições de Causalidade e Rendimento Escolar: Estudo de Evidência de Validade de Critério
Authors: Ferraz Adriana Satico , Santos Acácia Angeli dos , Almeida Leandro da Silva 
Published: June 2019

O objetivo deste estudo foi conferir a evidência de validade de critério concorrente para a Escala de Avaliação das Atribuições de Causalidade para Alunos do Ensino Fundamental (EAVAT-EF), tendo como variável critério o rendimento escolar. Considerou-se como medida de rendimento as classificações dos alunos em Língua Portuguesa e Matemática e a sua autopercepção de rendimento na escola. Participaram 661 alunos de escolas públicas brasileiras do Ensino Fundamental I e II (3.º ao 9.º ano), de ambos os gêneros, com idades entre 8 e 17 anos (M= 11.82; DP= 1.91). O modelo de predição do rendimento escolar constituiu-se pelos fatores da EAVAT-EF acrescido às variáveis gênero, número de repetências e autopercepção de rendimento, e foi testado nos dois ciclos do Ensino Fundamental. Este modelo funcionou apenas para o Ensino Fundamental II. No Ensino Fundamental I, por meio da análise de regressão linear, os fatores da EAVAT-EF tiveram a variância explicada menos expressiva para o rendimento escolar em comparação aos coeficientes padronizados identificados no Ensino Fundamental II. Considera-se que as atribuições de causalidade têm impacto no rendimento escolar avaliado por meio das classificações e da autopercepção de rendimento dos alunos, e vice-versa. Os resultados sugerem, ainda, que este impacto se consolida, tornando-se cada vez mais relevante com o avançar na escolaridade.
Palavras-chave:Atribuição causal; Motivação para a aprendizagem; Ensino Básico; Avaliação psicoeducacional