bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring implementation in global mental health: validation of a pragmatic implementation science measure in eastern Ukraine using an experimental vignette design
Authors: Haroz E. E. , Bolton P. , Nguyen A. J. , Lee C. , Bogdanov S. , Bass J. , Singh N. S. , Doty Benjamin , Murray L. 
Published: April 2019

Abstract
Background
There is mounting evidence supporting the effectiveness of task-shifted mental health interventions in low- and middle-income countries (LMIC). However, there has been limited systematic scale-up or sustainability of these programs, indicating a need to study implementation. One barrier to progress is a lack of locally relevant and valid implementation measures. We adapted an existing brief dissemination and implementation (D&I) measure which includes scales for acceptability, appropriateness, feasibility and accessibility for local use and studied its validity and reliability among a sample of consumers in Ukraine.

Methods
Local qualitative data informed adaptation of the measure and development of vignettes to test the reliability and validity. Participants were veterans and internally displaced persons (IDPs) recruited as part of a separate validity study of adapted mental health instruments. We examined internal consistency reliability, test-retest reliability, and construct and criterion validity for each scale on the measure. We randomly assigned half the participants to respond to a vignette depicting existing local psychiatric services which we knew were not well regarded, while the other half was randomized to a vignette describing a potentially more well-implemented mental health service. Criterion validity was assessed by comparing scores on each scale by vignette and by overall summary ratings of the programs described in the vignettes.

Results
N = 169 participated in the qualitative study and N = 153 participated in the validity study. Qualitative findings suggested the addition of several items to the measure and indicated the importance of addressing professionalism/competency of providers in both the scales and the vignettes. Internal consistency reliabilities ranged from α = 0.85 for feasibility to α = 0.91 for appropriateness. Test-rest reliabilities were acceptable to good for all scales (rho: 0.61–0.79). All scales demonstrated substantial and significant differences in average scores by vignette assignment (ORs: 2.21–5.6) and overall ratings (ORs: 5.1–14.47), supporting criterion validity.

Conclusions
This study represents an innovative mixed-methods approach to testing an implementation science measure in contexts outside the United States. Results support the reliability and validity of most scales for consumers in Ukraine. Challenges included large amounts of missing data due to participants’ difficulties responding to questions about a hypothetical program.
Work participation, mobility and foot symptoms in people with systemic lupus erythematosus: findings of a UK national survey
Authors: Stevens M. J. , Walker‐Bone K. , Culliford D. J. , Alcacer‐Pitarch B. , Blake A. , Hopkinson N. , Teh L. S. , Vital E. M. , Edwards C. J. , Williams A. E. , Cherry L. 
Published: April 2019

AbstractObjectiveThe aim of this study was to investigate whether foot and lower limb related symptoms were associated with work participation and poor mobility in people with Systemic Lupus Erythematosus (SLE).MethodA quantitative, cross‐sectional, self‐reported survey design was utilised. People with SLE from six United Kingdom (UK) treatment centres and a national register were invited to complete a survey about lower limb and foot health, work participation and mobility. Data collected included work status and the prevalence of foot symptoms. The focus of the analyses was to explore potential associations between poor foot health work non‐participation.ResultsIn total, 182 useable surveys were returned. Seventy‐nine respondents reported themselves as employed and 32 reported work non‐participation. The remaining were retired due to age or reported work non‐participation for other reasons. Work non‐participation due to foot symptoms was significantly associated with difficulty walking (p = 0.024), past episodes of foot swelling (p = 0.041), and past episodes of foot ulceration (p = 0.018). There was a significant increase in foot disability scores amongst those not working (mean 18.13, 95% CI: 14.85–21.41) compared to those employed (mean 10.16, 95% CI: 8.11–12.21).ConclusionsTwenty‐nine% of people with SLE reported work non‐participation because of lower limb or foot problems. Our results suggest that foot health and mobility may be important contributors to a persons' ability to remain in work and should be considered as part of a clinical assessment.
Comment on “Earthquake-induced prompt gravity signals identified in dense array data in Japan” by Kimura et al.
Authors: Vallée Martin , Ampuero Jean Paul , Juhel Kévin , Bernard Pascal , Montagner Jean-Paul , Barsuglia Matteo 
Published: April 2019

AbstractA recent work by Kimura et al. (Earth Planets Space 71:27, 2019. https://doi.org/10.1186/s40623-019-1006-x) (hereafter referred to as K19) claims to provide the first observational constraints on the prompt elastogravity signals (PEGS) induced by an earthquake. To make their claim, the authors argue that the observations shown in Vallée et al. (Science 358:1164–1168, 2017. https://doi.org/10.1126/science.aao0746) (hereafter referred to as V17) are spurious and their modeling inaccurate. Here we show that K19’s claim is invalid because it is based on flawed data processing. In fact, K19’s analysis involves an incomplete correction of the instrument response of broadband seismic sensors, which essentially dismisses low-frequency components of the data that are critical for the detection of intrinsically low-frequency signals such as PEGS. As a direct consequence, signals are much more difficult to observe than in V17, where the low part of the signal spectrum is carefully taken into account. This deficient data processing also explains why the signal amplitude reported by K19 after stacking data from multiple stations is lower than the individual signals reported by V17. Moreover, failing to take appropriate measures of data quality control, K19 used signals from low-quality sensors to call into question the signals detected by high-quality sensors. Finally, K19 use an inadequate simulation approach to model PEGS, in which the important effect of the ground acceleration induced by gravity changes is ignored. In summary, K19 do not show any viable arguments to question the observations and modeling of PEGS presented in V17.
Wnt signaling mediates new nephron formation during zebrafish kidney regeneration
Authors: Kamei Caramai N. , Gallegos Thomas F. , Liu Yan , Hukriede Neil , Drummond Iain A. 
Published: April 2019

ABSTRACT
Zebrafish kidneys use resident kidney stem cells to replace damaged tubules with new nephrons: the filtration units of the kidney. What stimulates kidney progenitor cells to form new nephrons is not known. Here, we show that wnt9a and wnt9b are induced in the injured kidney at sites where frizzled9b- and lef1-expressing progenitor cells form new nephrons. New nephron aggregates are patterned by Wnt signaling, with high canonical Wnt-signaling cells forming a single cell thick rosette that demarcates: domains of cell proliferation in the elongating nephron; and tubule fusion where the new nephron plumbs into the distal tubule and establishes blood filtrate drainage. Pharmacological blockade of canonical Wnt signaling inhibited new nephron formation after injury by inhibiting cell proliferation, and resulted in loss of polarized rosette structures in the aggregates. Mutation in frizzled9b reduced total kidney nephron number, caused defects in tubule morphology and reduced regeneration of new nephrons after injury. Our results demonstrate an essential role for Wnt/frizzled signaling in adult zebrafish kidney development and regeneration, highlighting conserved mechanisms underlying both mammalian kidney development and kidney stem cell-directed neonephrogenesis in zebrafish.
A dual function of FGF signaling in Xenopus left-right axis formation
Authors: Schneider Isabelle , Kreis Jennifer , Schweickert Axel , Blum Martin , Vick Philipp 
Published: April 2019

ABSTRACT
Organ left-right (LR) asymmetry is a conserved vertebrate feature, which is regulated by left-sided activation of Nodal signaling. Nodal asymmetry is established by a leftward fluid-flow generated at the ciliated LR organizer (LRO). Although the role of fibroblast growth factor (FGF) signaling pathways during mesoderm development is conserved, diverging results from different model organisms suggest a non-conserved function in LR asymmetry. Here, we demonstrate that FGF is required during gastrulation in a dual function at consecutive stages of Xenopus embryonic development. In the early gastrula, FGF is necessary for LRO precursor induction, acting in parallel with FGF-mediated mesoderm induction. During late gastrulation, the FGF/Ca2+-branch is required for specification of the flow-sensing lateral LRO cells, a function related to FGF-mediated mesoderm morphogenesis. This second function in addition requires input from the calcium channel Polycystin-2. Thus, analogous to mesoderm development, FGF activity is required in a dual role for laterality specification; namely, for generating and sensing leftward flow. Moreover, our findings in Xenopus demonstrate that FGF functions in LR development share more conserved features across vertebrate species than previously anticipated.
Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule
Authors: Martínez-Corrales Guillermo , Cabrero Pablo , Dow Julian A. T. , Terhzaz Selim , Davies Shireen-A. 
Published: April 2019

ABSTRACT
The GATA family of transcription factors is implicated in numerous developmental and physiological processes in metazoans. In Drosophila melanogaster, five different GATA factor genes (pannier, serpent, grain, GATAd and GATAe) have been reported as essential in the development and identity of multiple tissues, including the midgut, heart and brain. Here, we present a novel role for GATAe in the function and homeostasis of the Drosophila renal (Malpighian) tubule. We demonstrate that reduced levels of GATAe gene expression in tubule principal cells induce uncontrolled cell proliferation, resulting in tumorous growth with associated altered expression of apoptotic and carcinogenic key genes. Furthermore, we uncover the involvement of GATAe in the maintenance of stellate cells and migration of renal and nephritic stem cells into the tubule. Our findings of GATAe as a potential master regulator in the events of growth control and cell survival required for the maintenance of the Drosophila renal tubule could provide new insights into the molecular pathways involved in the formation and maintenance of a functional tissue and kidney disease.
STIM1-dependent membrane insertion of heteromeric TRPC1–TRPC4 channels in response to muscarinic receptor stimulation
Authors: Harada Keita , Matsuoka Hidetada , Inoue Masumi 
Published: April 2019

ABSTRACT
Muscarinic receptor stimulation results in activation of nonselective cation (NSC) channels in guinea pig adrenal medullary (AM) cells. The biophysical and pharmacological properties of the NSC channel suggest the involvement of heteromeric channels of TRPC1 with TRPC4 or TRPC5. This possibility was explored in PC12 cells and guinea pig AM cells. Proximity ligation assay (PLA) revealed that when exogenously expressed in PC12 cells, TRPC1 forms a heteromeric channel with TRPC4, but not with TRPC5, in a STIM1-dependent manner. The heteromeric TRPC1–TRPC4 channel was also observed in AM cells and trafficked to the cell periphery in response to muscarine stimulation. To explore whether heteromeric channels are inserted into the cell membrane, tags were attached to the extracellular domains of TRPC1 and TRPC4. PLA products developed between the tags in cells stimulated by muscarine, but not in resting cells, indicating that muscarinic stimulation results in the membrane insertion of channels. This membrane insertion required expression of full-length STIM1. We conclude that muscarinic receptor stimulation results in the insertion of heteromeric TRPC1–TRPC4 channels into the cell membrane in PC12 cells and guinea pig AM cells.
The Effects of Vascular Cognitive Impairment on the Thickness of the Granular Cell Layer of the Dentate Gyrus within the Hippocampus in a Mouse Model
Authors: Radhakrishnan Akshaya , Jadavji Nafisa 
Published: April 2019

Vascular Cognitive Impairment (VCI) is a form of dementia, most prevalent after Alzheimer’s Disease. However, VCI remains the second leading cause for dementia because it restricts blood flow to the brain and there are currently no treatments. There has been a positive correlation between VCI and hippocampal atrophy reported. Diet such as deficiencies in folic acid, is a modifiable risk factor for neurodegeneration. In the present study, a mouse model of VCI was combined with a deficiency in folic acid to assess hippocampal morphology. Animals were split into 4 experimental groups where they were placed into a control diet (CD) or folic acid deficient diet (FADD), and later these animals either had microcoils implanted around their common carotid arteries to model VCI or a sham, control surgery. For hippocampal morphological analysis, the thickness of the granular cell layer of the dentate gyrus within the hippocampus was measured. It was hypothesized that a mouse model of VCI with microcoil treatment and reduced levels of folic acid would reduce blood flow, and increase cell death resulting in a reduced thickness of the granular cell layer within the dentate gyrus of the hippocampus. Our results show that thickness had an increasing trend in the in the FADD microcoil group. These data suggest that there may be an additional factor coming into play such as compensation by neural stem cells that needs to be further researched.
Patient reported outcomes and neuropsychological testing in patients with chronic non-cancer pain in long-term opioid therapy: a pilot study
Authors: Diasso Pernille D. K. , Sjøgren Per , Højsted Jette , Nielsen Susanne D. , Main Katharina M. , Kurita Geana P. 
Published: April 2019

Abstract

Background and aims
Opioid consumption has increased dramatically in patients with chronic non-cancer pain (CNCP), but long-term consequences are still unclear. The aim of this study is to investigate the effects of long-term opioid treatment on pain, cognition, mood, sleep and quality of life in CNCP patients.

Methods
In this cross-sectional pilot study, two groups of patients with CNCP treated in a multidisciplinary pain center were selected: (1) opioid group: ≥30 mg morphine equivalent/day for >4 weeks, and (2) control group: no opioid consumption for >4 weeks. Socio-demographic data, alcohol consumption, smoking habits and body mass index (BMI) were registered and pain (brief pain inventory), mood (Hospital Anxiety and Depression Scale), sleep (Pittsburgh Sleep Quality Index) and quality of life (RAND 36-Item Health Survey) were assessed. Continuous Reaction Time and the Digit Span Test were used to evaluate cognitive function. Data was analyzed with a Fisher’s exact test and Wilcoxon two-sample test.

Results
Forty-two patients with CNCP were included (21 in each group). No differences regarding socio-demographics, smoking/alcohol habits and duration, type, or intensity of pain were found. More patients in the opioid group had significantly higher BMI (62% above BMI 25 vs. 33.3%, p = 0.042). Consequently, the subsequent data analyses were controlled for BMI. The two groups did not differ in pain, cognition, anxiety, depression, sleep or quality of life but both showed lower values than the normal standards. Further, the opioid group presented a tendency to lower ratings regarding pain and social function and performed below the normal cut off in the continuous reaction time.

Conclusions
No significant differences between the two groups were found regarding any of the above-mentioned variables. Interestingly, the patients assessed, regardless of taking opioids or not, could be classified with moderate pain intensity, anxiety and low quality of sleep and life compared to norm standards.

Implications
The findings of this pilot study suggested that long-term opioid treatment may influence pain and quality of life among CNCP patients. A larger cohort is needed to verify these findings.
Difference in the ascending reticular activating system injury between mild traumatic brain injury and cerebral concussion
Authors: Jang Sung Ho , Kim Seong Ho , Lee Han Do 
Published: April 2019

Abstract

Introduction
We investigated differences in the ascending reticular activating system (ARAS) injuries between patients with mild traumatic brain injury (mTBI) and cerebral concussion by using diffusion tensor tractography (DTT).

Methods
Thirty-one patients with mTBI, 29 patients with concussion, and 30 control subjects were recruited. We used DTT to reconstruct the lower ventral and dorsal ARAS, and the upper ARAS. The fractional anisotropy (FA) value and the fiber number (FN) of the lower ventral and dorsal ARAS, and the upper ARAS were determined.

Results
Significant differences were observed in the FA values of the lower ventral and dorsal ARAS on both sides between the mTBI and control groups and between the concussion and control groups (p < 0.05). The FN value was significantly different in the lower ventral ARAS on both sides between the concussion and control groups and between the mTBI and concussion groups (p < 0.05).

Conclusion
Both the mTBI and concussion patients suffered injuries in the lower ventral and dorsal ARAS, with the concussion patients exhibiting more severe injury in the ventral ARAS than that in the mTBI patients. These results suggest that the terms mTBI and concussion should be used differentially, even though they have used interchangeably for a long time.
Battle Rope Conditioning
Authors: Langford Emily L. , Wilhoite Sydni , Collum Connor , Weekley Hunter , Cook Jordan , Adams Kara , Snarr Ronald L. 
Published: April 2019

ABSTRACT
This column provides an analysis of the proper technique for battle rope conditioning. Specific musculature involvement, benefits of battle rope training, exercise technique, as well as advanced and beginning progressions are discussed. This dynamic movement is designed to improve cardiorespiratory endurance, muscular strength, endurance, and power. Specific variations for battle rope conditioning can provide various benefits to athletes such as enhancing sport-specific movements, increasing grip strength, and addressing unilateral deficits. Thus, the implementation of battle rope conditioning for an exercise regimen should be considered.
Neįvykęs pokalbis: Del Noce’ė ir Vattimo apie ateizmą, sekuliarizaciją ir nihilizmą
Authors: Markevičius Domantas 
Published: April 2019

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]
Straipsnyje siekiama suprobleminti Roberto Esposito pasiūlytą Augusto Del Noce’ės ir Gianni Vattimo požiūrių į sekuliarizaciją ir nihilizmą analizę ir pateikti alternatyvią jų santykio interpretaciją. Tuo tikslu lyginami Del Noce’ės ir Vattimo modernybės ir ateizmo apmąstymai ir jais paremtos skirtingos sekuliarizacijos bei nihilizmo fenomenų interpretacijos. Teigiama, kad Esposito neadekvačiai įvertina tarp Del Noce’ės ir Vattimo filosofijų kylantį prieštaravimą. Del Noce’ės moderniojo ateizmo interpretacija turėtų būti vertinama ne kaip „ištirpstanti“ Vattimo silpnajame mąstyme, o kaip svarbus šiuolaikinės italų filosofijos idėjinio pliuralumo tyrinėjant sekuliarizacijos ir nihilizmo fenomenus ženklas.
Dakwah Majelis Rasulullah dan Kecintaan Jama’ah kepada Dakwah Islam
Authors: Ikrima Anisatul , Diningrat Karsidi , Rojudin Rojudin 
Published: April 2019

This research discusses the Islamic proselytizing conducted by Majelis Rasulullah Tambun Cibitung Cikarang, the congregations love of the forum toward Islamic proselytizing, and the influence of Islamic proselytizing conducted by Majelis Rasulullah Tambun Cibitung Cikarang on the congregations of the forum’s love. The result showing the amount of X variable reach 46,4. After divided by the number of items obtained the number 4,64 and the amount of Y variable reach 47,36. After divided by the number of items obtained the number 4,736. The both of this variable has very high qualification because at interval 4,20-5,00. The correlation coefficient is 1,0. The value of correlation coefficient in this research was at the interval 0,81-1.00 which expressed perfect correlation. The influence Majelis Rasulullah, has coefficient 1,0 with 40% level of influence, it can be concluded that there are still around 60% from other factor which also influence to follower’s love in Islamic proselytizing.
Penelitian ini mengungkapkan dakwah Islam yang dilakukan oleh Majelis Rasulullah Tambun Cibitung Cikarang, kecintaan jama’ah terhadap dakwah Islam, dan pengaruh dakwah Islam yang dilakukan Majelis Rasulullah Tambun Cibitung Cikarang terhadap kecintaan jama’ah. Metode Penelitian menggunakan analisis kuantitatif. Hasil penelitian menunjukkan jumlah variabel X mencapai 46,4. Setelah dibagi jumlah item diperoleh angka 4,64 dan jumlah Variabel Y mencapai 47,36. Setelah dibagi oleh jumlah item diperoleh angka 4,736. Kedua variabel ini memiliki kualifikasi sangat tinggi karena berada pada interval 4,20–5,00. Koefisien kolerasi sebesar 1,0. Nilai koefisien korelasi pada penelitian ini berada pada interval 0,81-1,00 yang dinyatakan korelasi sempurna. Pengaruh Majelis Rasulullah, koefisiennya 1,0 dengan kadar pengaruhnya 40% hal tersebut dapat disimpulkan bahwa masih ada sekitar 60% dari faktor lain yang turut mempengaruhi terhadap kecintaan jama’ahnya dalam dakwah Islam.