bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancement of indirect functional connections with shortest path length in the adult autistic brain
Authors: Guo Xiaonan , Simas Tiago , Lai Meng‐Chuan , Lombardo Michael V. , Chakrabarti Bhismadev , Ruigrok Amber N. V. , Bullmore Edward T. , Baron‐Cohen Simon , Chen Huafu , Suckling John ,   MRC AIMS Consortium
Published: August 2019

AbstractAutism is a neurodevelopmental condition characterized by atypical brain functional organization. Here we investigated the intrinsic indirect (semi‐metric) connectivity of the functional connectome associated with autism. Resting‐state functional magnetic resonance imaging scans were acquired from 65 neurotypical adults (33 males/32 females) and 61 autistic adults (30 males/31 females). From functional connectivity networks, semi‐metric percentages (SMPs) were calculated to assess the proportion of indirect shortest functional pathways at global, hemisphere, network, and node levels. Group comparisons were then conducted to ascertain differences between autism and neurotypical control groups. Finally, the strength and length of edges were examined to explore the patterns of semi‐metric connections associated with autism. Compared with neurotypical controls, autistic adults displayed significantly higher SMP at all spatial scales, similar to prior observations in adolescents. Differences were primarily in weaker, longer‐distance edges in the majority between networks. However, no significant diagnosis‐by‐sex interaction effects were observed on global SMP. These findings suggest increased indirect functional connectivity in the autistic brain is persistent from adolescence to adulthood and is indicative of reduced functional network integration.
Elevated Fatty Liver Index as a Risk Factor for All‐Cause Mortality in Human Immunodeficiency Virus–Hepatitis C Virus–Coinfected Patients (ANRS CO13 HEPAVIH Cohort Study)
Authors: Barré Tangui , Protopopescu Camelia , Bani‐Sadr Firouzé , Piroth Lionel , Rojas Rojas Teresa , Salmon‐Ceron Dominique , Wittkop Linda , Esterle Laure , Sogni Philippe , Lacombe Karine , Chas Julie , Zaegel Olivia , Chaix Marie‐Laure , Miailhes Patrick , Serfaty Lawrence , Marcellin Fabienne , Carrieri Maria Patrizia ,   ANRS CO13 HEPAVIH Study Group
Published: August 2019

Background and Aims
Human immunodeficiency virus (HIV)–hepatitis C virus (HCV)–coinfected patients are at high risk of metabolic complications and liver‐related events, which are both associated with hepatic steatosis and its progressive form, nonalcoholic steatohepatitis, a known risk factor for mortality. The fatty liver index (FLI), a noninvasive steatosis biomarker, has recently drawn attention for its clinical prognostic value, although its capacity to predict mortality risk in HIV–HCV‐coinfected patients has never been investigated. Using a Cox proportional hazards model for mortality from all causes, with data from the French National Agency for Research on Aids and Viral Hepatitis CO13 HEPAVIH cohort (983 patients, 4,432 visits), we tested whether elevated FLI (≥60) was associated with all‐cause mortality.

Approach and Results
After multiple adjustment, individuals with FLI ≥ 60 had almost double the risk of all‐cause mortality (adjusted hazard ratio [95% confidence interval], 1.91 [1.17‐3.12], P = 0.009), independently of the following factors: HCV cure (0.21 [0.07‐0.61], P = 0.004), advanced fibrosis (1.77 [1.00‐3.14], P = 0.05), history of hepatocellular carcinoma and/or liver transplantation (7.74 [3.82‐15.69], P < 10−3), history of indirect clinical signs of cirrhosis (2.80 [1.22‐6.41], P = 0.015), and HIV Centers for Disease Control and Prevention clinical stage C (2.88 [1.74‐4.79], P < 10−3).

Conclusions
An elevated FLI (≥60) is a risk factor for all‐cause mortality in HIV–HCV‐coinfected patients independently of liver fibrosis and HCV cure. In the present era of nearly 100% HCV cure rates thanks to direct‐acting antivirals, these findings encourage the more systematic use of noninvasive steatosis biomarkers to help identify coinfected patients with higher mortality risk.
The lenalidomide/bortezomib/dexamethasone regimen for the treatment of blastic plasmacytoid dendritic cell neoplasm
Authors: Marmouset Vincent , Joris Magalie , Merlusca Lavinia , Beaumont Marie , Charbonnier Amandine , Marolleau Jean‐Pierre , Gruson Bérengère 
Published: August 2019

AbstractWe describe the use and value of a lenalidomide/bortezomib/dexamethasone regimen for the treatment of three patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN, a disease that lacks a consensus treatment). After five cycles of chemotherapy, we observed two complete responses and one clinical remission. Together with the encouraging literature data on the effects of lenalidomide and bortezomib on BPDCN cells, our results might prompt further investigations of this regimen's value in BPDCN.
Challenges facing oncology nurses in Jordan: A qualitative study
Authors: Al zoubi Ahmad M. , Saifan Ahmad Rajeh , Alrimawi Intima , Aljabery Mohannad A. 
Published: August 2019

SummaryBackgroundThe literature shows that oncology nurses have more stressors than nurses in other units. They face many challenges both within and outside the work environment that affect them negatively. Most of the reviewed studies concerning these challenges were conducted in developed countries.AimThe purpose of this study was to explore the challenges experienced by oncology nurses in Jordan during their daily practice.MethodA qualitative descriptive approach was adopted. Semistructured individual face‐to‐face interviews were conducted with 24 nurses. Participants were selected from oncology departments in one of the biggest governmental hospitals in Jordan.ResultsTwo main themes were drawn from the data analysis. The first discussed the personal challenges that oncology nurses encountered. These included emotional attachment to patients and difficulties in separating work and personal life. The second related to organizational challenges in the work environment, which included the nurses' lack of authority to inform patients about their diseases, nursing staff and supply shortages, and a lack of orientation programs. All of these factors affected the psychological status of the nurses.ConclusionsThe results of this study indicated that the working environment for oncology nurses is highly stressful and demanding and these nurses face many challenges in their work. The understanding and consideration of these challenges by stakeholders, managers, and organizational leaders would lead to improvements in the nurses' psychological state, thereby enhancing the quality of care in these units and helping with staff retention.
The NTP Report on Carcinogens: A valuable resource for public health, a challenge for regulatory science
Authors: Suarez‐Torres Jose Daniel , Alzate Juan Pablo , Orjuela‐Ramirez Maria Erley 
Published: August 2019

AbstractThe Report on Carcinogens (RoC), from the National Toxicology Program of the USA, is one of the world‐leading programs for the identification and acknowledgment of substances that represent a hazard of cancer to humans. RoC covers several essential topics concerning environmental, occupational, and pharmaceutical agents that are known to be, or reasonably anticipated to be carcinogenic to humans. To promote the highest exploitation by its potential users, several RoC aspects and features were put together into one article. For doing so, a comprehensive description is provided regarding RoC history, scope, general features, listing criteria, contents, handbook, and website. Secondary and tertiary aims for this work were (a) to point out some improvement opportunities for the RoC, and (b) to discuss pending issues in regulatory science and cancer hazard assessments. In this regard, for agents classified as probably, likely, reasonably anticipated, possibly or suspected to be a human carcinogen, there is a lack of quantitative knowledge concerning the likelihood of those agents actually being carcinogenic to humans. Elucidating these probabilities is necessary, because the duration of current regulations and the arrival of new acts may depend on it. On the other hand, there is a dramatic imbalance in priorities toward carcinogens, compared with non‐carcinogens, in current cancer hazard identification programs. That vision may ignore that the availability on the market of chemicals classified as probably not carcinogenic to humans can also be important for the employment, alimentation, economy, quality of life of consumers, and human health.
Distinguishing structural features between Crohn's disease and gastrointestinal luminal tuberculosis using Mueller matrix derived parameters
Authors: Liu Teng , Lu Min , Chen Binguo , Zhong Qinsong , Li Jingyu , He Honghui , Mao Hua , Ma Hui 
Published: August 2019

AbstractRecently, the incidence of inflammatory bowel diseases, especially the Crohn's disease (CD) and gastrointestinal luminal tuberculosis (ITB), has grown rapidly worldwide. Currently there is no general gold standard to distinguish between CD and ITB tissues, which both have tuberculosis and surrounding fibrous structures. Mueller matrix imaging technique is suitable for describing the location, density and distribution behavior of such fibrous structures. In this study, we apply the Mueller matrix microscopic imaging to the CD and ITB tissue samples. The 2D Mueller matrix images of the CD and ITB tissue slices are measured using the Mueller matrix microscope developed in our previous study, then the Mueller matrix polar decomposition and Mueller matrix transformation parameters are calculated. To evaluate the distribution features of the fibrous structures surrounding the tuberculosis areas more quantitatively and precisely, we analyze the retardance related Mueller matrix derived parameters, which show clear different distribution behaviors between the CD and ITB tissues, using the Tamura image processing method. It is demonstrated that the Mueller matrix derived parameters can reveal the structural features of tuberculosis areas and be used as quantitative indicators to distinguish between CD and ITB tissues, which may be useful for the clinical diagnosis.
A preliminary study on the differential expression of long noncoding RNAs and messenger RNAs in obese and control mice
Authors: Li Ping , Chen Xiaoyu , Chang Xuelian , Tang Tiantian , Qi Kemin 
Published: August 2019

AbstractObesity has become one of the public health problems that threatens children's health, but its specific etiology and pathogenesis are still unclear. Recently, many long noncoding RNAs (lncRNAs) have been shown to be involved in the occurrence of obesity. However, their roles are still poorly understood. Thus, the aim of this study was to discover the profiles of the lncRNAs and messenger RNAs (mRNAs) altered in obesity. Epididymal fat samples were collected from mice fed with control and high‐fat diets (HFD) for 16 weeks to investigate the differentially expressed lncRNAs and mRNAs by lncRNA microarray, after which seven lncRNAs and nine mRNAs were validated using reverse‐transcription polymerase chain reaction (RT‐PCR). Bioinformatics analysis and predictions were used to determine the potential biofunctions of these differentially expressed lncRNAs. Then a coexpression network was constructed to determine the transcriptional regulatory relationship of the differentially expressed lncRNAs and mRNAs between the control and HFD groups. The body weight of the HFD group was much higher than that of the control group, as a result of the increased energy intake. In total, 8421 differentially expressed lncRNAs and 6840 mRNAs were profiled using the lncRNAs microarray. Bioinformatics predictions and the coexpression network all indicated that the occurrence of obesity was attributed to those differentially expressed lncRNAs and mRNAs associated with energy metabolism, cell differentiation, and oxidative phosphorylation. The expression levels of Cyp2e1, Atp5b, Hibch, Cnbp, Frmd6, Ptchd3, ENSMUST00000155948, AK140152, ENSMUST00000135194, and ENSMUST00000180861 were significantly different between the control and HFD groups. All these Results suggested that obesity was partially attributed to those lncRNAs associated with energy metabolism, cell differentiation, and oxidative phosphorylation.
Prognostic role of body composition parameters in gastric/gastroesophageal junction cancer patients from the EXPAND trial
Authors: Hacker Ulrich T. , Hasenclever Dirk , Linder Nicolas , Stocker Gertraud , Chung Hyun‐Cheol , Kang Yoon‐Koo , Moehler Markus , Busse Harald , Lordick Florian 
Published: August 2019

AbstractBackgroundBody fat and/or muscle composition influences prognosis in several cancer types. For advanced gastric and gastroesophageal junction cancer, we investigated which body composition parameters carry prognostic information beyond well‐established clinical parameters using robust model selection strategy such that parameters identified can be expected to generalize and to be reproducible beyond our particular data set. Then we modelled how differences in these parameters translate into survival outcomes.MethodsFat and muscle parameters were measured on baseline computed tomography scans in 761 patients with advanced gastric or gastroesophageal junction cancer from the phase III EXPAND trial, undergoing first‐line chemotherapy. Cox regression analysis for overall survival (OS) and progression‐free survival (PFS) included body composition parameters and clinical prognostic factors. All continuous variables were entered linearly into the model as there was no evidence of non‐linear prognostic impact. For transferability, the final model included only parameters that were picked by Bayesian information criterion model selection followed by bootstrap analysis to identify the most robust model.ResultsMuscle and fat parameters formed correlation clusters without relevant between‐cluster correlation. Mean muscle attenuation (MA) clusters with the fat parameters. In multivariate analysis, MA was prognostic for OS (P < 0.0001) but not for PFS, while skeletal muscle index was prognostic for PFS (P = 0.02) but not for OS. Worse performance status Eastern Cooperative Oncology Group (ECOG 1/0), younger age (on a linear scale), and the number of metastatic sites were strong negative clinical prognostic factors for both OS and PFS. MA remained in the model for OS (P = 0.0001) following Bayesian information criterion model selection in contrast to skeletal muscle index that remained prognostic for PFS (P = 0.009). Applying stricter criteria for transferability, MA represented the only prognostic body composition parameter for OS, selected in >80% of bootstrap replicates. Finally, Cox model‐derived survival curves indicated that large differences in MA translate into only moderate differences in expected OS in this cohort.ConclusionsAmong body composition parameters, only MA has robust prognostic impact for OS. Data suggest that treatment approaches targeting muscle quality are unlikely to prolong OS noticeably on their own in advanced gastric cancer patients, indicating that multimodal approaches should be pursued in the future.
Living cell‐based regenerative medicine technologies for periodontal soft tissue augmentation
Authors: McGuire Michael K. , Tavelli Lorenzo , Feinberg Stephen E. , Rasperini Giulio , Zucchelli Giovanni , Wang Hom‐Lay , Giannobile William V. 
Published: August 2019

AbstractThe cultivation of human living cells into scaffolding matrices has progressively gained popularity in the field of periodontal wound healing and regeneration. Living cellular constructs based on fibroblasts, keratinocytes alone or in combination have been developed and used as alternatives to autogenous soft tissue grafts in keratinized tissue augmentation and in root coverage procedures. Their promising advantages include reduced patient morbidity, unlimited graft availability, and comparable esthetics. This manuscript reviews soft tissue augmentation and root coverage procedures using bioengineered living cellular therapy and highlights their expected clinical, esthetic, and patient‐related outcomes.
Spatiotemporal changes of permafrost in the Headwater Area of the Yellow River under a changing climate
Authors: Sheng Yu , Ma Shuai , Cao Wei , Wu Jichun 
Published: August 2019

AbstractThis article attempts to predict the spatiotemporal changes of permafrost in the Headwater Area of the Yellow River (HAYR) on the northeastern Qinghai‐Tibet Plateau, Southwest China by using field monitoring and numerical models. Permafrost in the HAYR is categorized into four types: low‐ and high‐ice‐content high‐plain permafrost and low‐ and high‐ice‐content alpine permafrost. According to these permafrost types, changes in permafrost temperature were calculated by coupling a geometric model with the soil thermal conduction model. Based on the calculation results, this paper evaluates the changes of permafrost in the HAYR over the past 50 years and predicts the change trends of permafrost in the HAYR under the scenarios of RCP2.6, RCP6.0, and RCP8.5 for possible climate change in 2050 and 2010 from the Intergovernmental Panel on Climate Change Fifth Assessment Report. The results show that (a) in the process of permafrost degradation, the same permafrost type at different degradation stages results in different modes and rates of increasing temperature. The response of permafrost to climate change differs in various degradation stages of permafrost; (b) from 1972 to 2012, the areal extent of permafrost degradation was 1,056 km2, resulting from a sharp air temperature increase after the 1980s. By 2050, the areal extent of permafrost degradation into seasonal frost is similar under the three scenarios of climate change. The areal extent of permafrost degradation is 2,224, 2,347, and 2,559 km2 or 7.5%, 7.9%, and 8.6% of the total area in the HAYR, respectively. In RCP2.6, the areal extent of permafrost degradation into seasonal frost by 2100 would be approximately 3,500 km2 greater than that by 2050. In RCP6.0, the areal extent of permafrost degradation by 2100 would be 10,000 km2 or 32.9% of the total area in the HAYR. In RCP8.5, the area of permafrost degradation by 2100 would be 18,492 km2 or 62.2% of the total area in the HAYR; (c) the active layer thickness (ALT) in the HAYR would increase significantly. The average of the ALT was 1.51 m by 1972 and 2.01 m by 2012, respectively. Under the RCP2.6, RCP6.0, and RCP8.5 scenarios, the basin‐wide average of ALT would be 2.21, 2.40, and 3.08 m by 2050 and 2.78, 4.07, and 4.39 m by 2100, respectively.
Solventless Synthesis and Patterning of UV‐Responsive Poly(allyl methacrylate) Film
Authors: Yang Huidong , Wang Hong , Feng Jingang , Ye Yumin , Liu Wenna 
Published: August 2019

AbstractAsymmetric divinyl monomers are attractive candidates for constructing functional polymer thin films owing to their ability to undergo further reactions after polymerization. Here, the first solventless synthesis of poly(allyl methacrylate) (PAMA) film with retention of abundant allyl groups using initiated chemical vapor deposition (iCVD) is reported. It is demonstrated that lower substrate and filament temperatures lead to better allyl retention, while higher temperatures lead to intramolecular cyclization. The retained allyl groups can be further crosslinked under UV light, and the crosslinking degree can be easily tuned by adjusting the exposure time. Patterning of iCVD PAMA films with 20 µm resolution using a TEM grid as photomask is also demonstrated. The reported synthesis method suggests possible solventless incorporation of AMA in thin films as a latent crosslinker or anchoring sites for further functionalization. The solventless patterning can also extend patterning technique to solvent‐sensitive and non‐planar substrates.
Improving the precipitation forecast over the Eastern Mediterranean using a smoothed time‐lagged ensemble
Authors: Khain Pavel , Levi Yoav , Shtivelman Alon , Vadislavsky Elyakom , Brainin Evgeny , Stav Nir 
Published: August 2019

AbstractIn the absence of convection permitting numerical weather prediction (NWP) ensembles, the most recent deterministic NWP precipitation forecast is usually addressed. However, the exact intensity, location and timing of a deterministic precipitation forecast is not always reliable because of the chaotic nature and complexity of precipitation formation mechanisms. This study examines a way to optimize the use of precipitation forecasts for deterministic NWP models. More specifically, it suggests using a spatially smoothed time‐lagged ensemble (TLE) to obtain more reliable precipitation forecasts. A global NWP model (integrated forecast system—IFS) and a regional convection permitting NWP model (COSMO) over the Eastern Mediterranean during the period 2016–2018 were used for the analysis. First, the paper defines light, light–moderate and moderate intensities for 6 hr accumulated precipitation (6hAP) and investigates the corresponding definitions for 1 hr accumulated precipitation (1hAP). Next, fractional skill score (FSS) are used to estimate the optimal spatial smoothing scale of a deterministic precipitation forecast for the three intensity categories for the 6hAP and 1hAP. The FSS is also used to compare COSMO and IFS deterministic precipitation forecasts, and to analyse the skill degradation with the forecast range. It is quantitatively shown that the useful scale of precipitation forecasts is smaller for larger accumulation time intervals. Finally, precipitation forecasts for TLE are formed from successive smoothed deterministic forecasts and compared with the most recent deterministic forecast. It is found that, on average, TLEs have better skills for both 6hAP and 1hAP. The reason for this improvement in skill is illustrated using a case study as an example.
On a class of systems of rational second‐order difference equations solvable in closed form
Authors: Stević Stevo 
Published: August 2019

We show that the following nonlinear system of difference equations

urn:x-wiley:mma:media:mma5809:mma5809-math-0001
where parameters a,b,c,d and initial values x−1,x0,y−1,y0 are real numbers, is solvable in closed form, considerably generalizing some recent results. To do this, we use the method of transformation along with several tricks, transforming the system to some known solvable difference equations, by use of which we obtain some closed‐form formulas for general solution to the system. The following five cases are considered separately: (1) c=0; (2) d=0; (3) a=0; (4) b=0; and (5) abcd≠0.