bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous infusion of simoctocog alfa in haemophilia A patients undergoing surgeries
Authors: Holme Pål Andre , Tjønnfjord Geir E. 
Published: November 2018

IntroductionThere are two major principles for coagulation factor replacement in the clinical management of surgical procedures in patients with haemophilia, repetitive bolus injections every 6‐12 hours or administration of coagulation factor concentrates by continuous infusion.AimThe aim was to investigate the efficacy of simoctocog alfa (human‐cl rhFVIII) delivered by continuous infusion for bleeding prophylaxis during surgery in patients with haemophilia A.MethodsWe investigated the use of continuous infusion with simoctocog alfa in haemophilia A patients undergoing major surgical procedures at Oslo University Hospital from September 2015 to March 2018. The objectives were haemostatic outcome, in vivo recovery, stability over time at room temperature (3 days) and inhibitor development.ResultsSimoctocog alfa demonstrated treatment success in terms of haemostatic efficacy in 100% of major surgeries used as CI: 87% (n=21) excellent; 13% (n=3) good. No erythrocyte transfusions were required in any patient, no adverse events occurred and no inhibitors developed. The product was stable for 3 days at room temperature without loss of activity. Mean in vivo recovery was 1.8 (0.3) (IU/mL/IU/kg).ConclusionContinuous infusion with simoctocog alfa was found to achieve good/excellent haemostatic efficacy in all procedures. No adverse events occurred and no inhibitors developed.
Common origin of sequential cutaneous CD30+ lymphoproliferations with nodal involvement evidenced by genome‐wide clonal evolution
Authors: Xerri Luc , Adélaïde José , Avenin Morgan , Guille Arnaud , Taix Sebastien , Bonnet Nathalie , Carbuccia Nadine , Garnier Séverine , Mescam Lenaïg , Murati Anne , Chaffanet Max , Coso Diane , Bouabdallah Reda , Bertucci François , Birnbaum Daniel 
Published: November 2018

AimsThis study sought to clarify the molecular pathways underlying the putative evolution from lymphomatoid papulosis (LyP) to cutaneous anaplastic large‐cell lymphoma (c‐ALCL) and lymph node invasion (LNI).Methods and resultsWe analysed nine sequential tumours from the same patient presenting with parallel evolution of LyP (n = 3) and c‐ALCL (n = 1) with LNI (n = 1), combined with systemic diffuse large B‐cell lymphoma (DLBCL) (n = 4). Clonality analysis showed a common clonal T‐cell origin in the five CD30+ lesions, and a common clonal B‐cell origin in the four DLBCL relapses. Array‐comparative genomic hybridisation and targeted next‐generation sequencing analysis demonstrated relative genomic stability of LyP lesions as compared with clonally related anaplastic large‐cell lymphoma (ALCL) tumours, which showed 4q and 22q13 deletions involving the PRDM8 and TIMP3 tumour suppressor genes, respectively. The three analysed CD30+ lesions showed mostly private (specific to each sample) genetic alterations, suggesting early divergence from a common precursor. In contrast, DLBCL tumours showed progressive accumulation of private alterations, indicating late divergence.ConclusionsSequential cutaneous and nodal CD30+ tumours were clonally related. This suggests that LyP, c‐ALCL and LNI represent a continuous spectrum of clonal evolution emerging from a common precursor of cutaneous CD30+ lymphoproliferations. Therefore, nodal ALCL tumours in the context of LyP should be considered as a form of transformation rather than composite lymphoma.
Clarifying model for continuity of care: A concept analysis
Authors: Bahr Sarah J. , Weiss Marianne E. 
Published: November 2018

AbstractAimThe aim is to clarify the use of the term continuity in the specific context of acute care hospitalization and discharge.BackgroundThe meaning of “continuity” is often co‐mingled with other concepts, specifically coordination and communication. To increase usefulness for contemporary concerns with the hospitalization‐postdischarge continuum, continuity of care is examined from the specific context of acute hospitalization and discharge.DesignConcept analysis.Data SourcesMedline via Ovid, Cochrane Library, Cinahl, and Google Scholar. Search years encompassed 2001–2016.Review MethodsRodgers evolutionary concept analysis method.ResultsA total of 50 papers were included in this concept analysis. Synthesis of findings from these papers resulted in a model of continuity of care that illustrates the hierarchical and interdependent relationship between time and setting, patient‐provider relationships, communication, and coordination in the context of discharge transitions.ConclusionThe continuity model provides a framework to assist in the design of multicomponent, interdisciplinary, integrated interventions that can then be tested for their effect on patient care practices and outcomes.
The limits of inequality: Public support for social policy across rich democracies
Authors: Breznau Nate , Hommerich Carola 
Published: November 2018

AbstractDoes public opinion react to inequality, and if so, how? The social harms caused by increasing inequality should cause public opinion to ramp up demand for social welfare protections. However, the public may react to inequality differently depending on institutional context. Using ISSP and WID data (1980‒2006), we tested these claims. In liberal institutional contexts (mostly English‐speaking), increasing income inequality predicted higher support for state provision of social welfare. In coordinated and universalist contexts (mostly of Europe), increasing inequality predicted less support. Historically higher income concentration predicted less public support, providing an account of the large variation in inequality within the respective liberal and coordinated contexts. The results suggest opinions in liberal societies – especially with higher historical inequality – reached the limits of inequality, reacting negatively; whereas in coordinated/universalist societies – especially with lower historical inequality – opinions moved positively, as if desiring more inequality.
Factors influencing clinical decision making used by mental health nurses to provide provisional diagnosis: A scoping review
Authors: Campbell Katrina , Massey Deb , Broadbent Marc , Clarke Karen‐Ann 
Published: November 2018

AbstractMedical diagnosis has traditionally been the role of medical officers. However, mental health nurses working in crisis/emergency settings within Australia are expected to provide a provisional diagnosis postassessment of a consumer. There is limited literature and understanding how mental health nurses develop a provisional diagnosis. In this scoping review, we aimed to first identify and describe the clinical decision‐making processes used by mental health nurses across a variety of clinical settings. Second, we sought to explore the factors influencing mental health nurse's diagnostic practice in a variety of settings. Literature was searched using CINAHL (EBSCOhost), PubMed, and ProQuest. Peer‐reviewed literature published between 2007 and 2017 was used for this scoping review. Two major themes were identified: clinical decision making (CDM) in mental health nursing and diagnostic practice in nursing. A combination of clinician, environmental, and patient factors were found to have influenced CDM. Furthermore, mental health nurses rely heavily on tacit knowledge when making clinical decisions. Little is known about the use of diagnostic practice in mental health nursing in Australia; however, the limited literature revealed an overlap between the factors which influence CDM and diagnostic practice, respectively. Further research is needed into the use of diagnostic practice in mental health nursing to develop frameworks to assist with CDM pertaining to application of provisional diagnosis by mental health nurses working in assessment environments.
Identification with arts‐based groups improves mental wellbeing in adults with chronic mental health conditions
Authors: Williams Elyse , Dingle Genevieve A. , Jetten Jolanda , Rowan Christian 
Published: November 2018

AbstractPeople experiencing chronic mental health conditions (CMHC) often report feeling socially marginalised. There is emerging evidence that social and mental wellbeing can be enhanced through participation in arts‐based programmes. In this paper, a social identity theoretical approach was applied to explore how participation in the arts may improve mental health in a longitudinal study. A one‐year prospective study of 34 choir members and 25 creative writing group members (Mage = 46, 51% female) with CMHC, involved three assessments of participants’ group identification and mental wellbeing, measured by the Warwick Edinburgh Mental Wellbeing Scale. The programmes were community‐based and facilitated by arts professionals. Multilevel modelling analyses demonstrated that participants’ mental wellbeing significantly improved over time. Greater identification with their arts‐based group (ABG) was significantly related to an increased rate of improvement in mental wellbeing. The trajectory of improvement in mental wellbeing did not differ between participants partaking in the choir or creative writing group. This study demonstrates that participation in ABGs can be effective in improving mental wellbeing in adults with chronic mental health problems, particularly for those who strongly identify with the group. This study supports ABG participation as an accessible component of mental health services.
The effects of health frame and target relevance in appearance social comparisons
Authors: Head Maggie L. , Bruchmann Kathryn 
Published: November 2018

AbstractSocial comparison powerfully influences on appearance self‐evaluations, but previous research has not examined the combined impact of target frame and relevance on appearance comparison outcomes. The present study examined the effect of target relevance and health frame in body‐ideal images on self‐evaluations in a mixed‐gender university‐based sample from the United States (N = 176; 58% female). Participants were randomly assigned to one of four conditions in which they viewed a body‐ideal image of a same‐sex target that varied in target relevance (peer or model) and health frame (extreme behaviors described as being healthy or unhealthy). We did not find evidence that comparisons with models or peers are different in their effects. And, consistent with hypotheses, the health frame of a comparison target’s eating and exercise behaviors influenced how participants perceived themselves and their health. Participants were more likely to take health advice from the target described as healthy, and felt better about their own health when comparing to healthy targets. We also found gender differences such that men were more satisfied with their physical health but women were more satisfied with their appearance. Overall, this research supports the importance of addressing peer comparisons and health literacy in body image interventions, which has long‐term implications for the prevention of eating and exercise pathology.
Picroside II attenuates hyperhomocysteinemia‐induced endothelial injury by reducing inflammation, oxidative stress and cell apoptosis
Authors: Wang Yunkai , Hong Yajun , Zhang Chunyu , Shen Yunli , Pan Ye Shen , Chen Rui Zhen , Zhang Qi , Chen Yi Han 
Published: November 2018

AbstractPicroside II (P‐II), one of the main active components of scrophularia extract, which have anti‐oxidative, anti‐inflammatory effects, but its effect on hyperhomocysteinemia (HHcy) induced endothelial injury remains to be determined. Here, we test whether P‐II protects HHcy‐induced endothelial dysfunction against oxidative stress, inflammation and cell apoptosis. In vitro study using HUVECs, and in hyperhomocysteinemia mouse models, we found that HHcy decreased endothelial SIRT1 expression and increased LOX‐1 expression, subsequently causing reactive oxygen species generation, up‐regulation of NADPH oxidase activity and NF‐κB activation, thereby promoting pro‐inflammatory response and cell apoptosis. Blockade of Sirt1 with Ex527 or siRNASIRT1 increased LOX‐1 expression, whereas overexpression of SIRT1 decreased LOX‐1 expression markedly. P‐II treatment significantly increased SIRT1 expression and reduced LOX‐1 expression, and protected against endothelial cells from Hcy‐induced oxidative injury, inflammation and apoptosis. However, blockade of SIRT1 or overexpression of LOX‐1 attenuated the therapeutic effects of P‐II. In conclusion, our results suggest that P‐II prevents the Hcy induced endothelial damage probably through regulating the SIRT1/LOX‐1 signaling pathway.
The frequency of arthritis in Adamantiades‐Behçet's disease in Greek patients
Authors: Vaiopoulos A.G. , Kapsimali V. , Kanakis M.A. , Vaiopoulos G. , Samarkos M. , Zouboulis C.C. , Kaklamanis P.G. 
Published: November 2018

AbstractBackground/ObjectivesMusculoskeletal manifestations are frequent in Adamantiades‐Behçet's disease (ABD) but only represent non‐specific clinical findings. They have not been included in the two commonly used sets of classification criteria. The occurrence of musculoskeletal manifestations at ABD onset may even delay or obscure the diagnosis; therefore, detailed knowledge of the different musculoskeletal manifestations is essential. Our objective was to describe musculoskeletal signs and their clinical course in Greek ABD patients.MethodsWe conducted a retrospective cohort study, which included all patients with ABD, who had been examined in our Rheumatology Outpatient Division from 1995 to 2010. The study included 224 ABD patients (140 male, 84 female) that fulfilled the International Criteria for the diagnosis of BD. For statistical analysis, we have used chi‐square and Fisher's exact tests.ResultsArthritis as a presenting sign was seen in 10.2% of our patients. During the follow‐up period, the frequency of arthritis was 58.4%. Monoarthritis was found in 32.8% and 22.6% of male and female patients, respectively (ns). During the follow‐up period, polyarthritis was only occasionally observed in male patients (2.14%). Oligoarthritis was assessed in 20.0% and 41.6% of male and female patients, respectively (P < 0.001), and was the only significantly different manifestation between sexes.ConclusionsMusculoskeletal manifestations are common in ABD both at presentation and during the disease course. The most frequent sign is mooarthritis. Oligoarthritis was the only significantly different articular manifestation between sexes (more common in women) in our study group.
HrQoL in hair loss‐affected patients with alopecia areata, androgenetic alopecia and telogen effluvium: the role of personality traits and psychosocial anxiety
Authors: Russo P.M. , Fino E. , Mancini C. , Mazzetti M. , Starace M. , Piraccini B.M. 
Published: November 2018

AbstractBackgroundIllness impact on HrQoL has been widely studied in hair loss‐affected patients, yet no study has addressed whether individual differences modulate HrQoL in patients with alopecia areata (AA), androgenetic alopecia (AGA) and telogen effluvium (TE).ObjectiveTo identify the personality dimensions most predictive of the impact of disease on HrQoL.MethodA single‐site cross‐sectional study was carried out in the Dermatology Unit of Sant'Orsola‐Malpighi Hospital, Bologna between September 2016 and September 2017. The study included 143 patients (105 females, ages 18–60 years) diagnosed with AA (n = 27), AGA (n = 80) and TE (n = 36). Illness severity, alopecia type, age, gender, education and civil status were documented. Health‐related quality of life (HrQoL), personality traits, trait anxiety, emotional intelligence, social anxiety and social phobia were also measured.ResultsAA, AGA and TE groups differed significantly for illness severity with most severe patients falling in AA type. For HrQoL, Gender × Group interaction resulted significant with AGA females reporting a higher impact of hair loss on quality of life than males, while TE males were more impacted by hair loss than AA and AGA males. Lower scores were obtained by AGA females than males on emotional intelligence while no significant differences were evidenced on other groups. A significant Gender × Group interaction was also found for trait anxiety, social phobia and social anxiety: consistently, AGA females reported higher scores than AGA males in all three measures. Finally, discriminant analysis evidenced that anxiety‐related traits can contribute to reliably predict hair loss impact on HrQoL, regardless of illness severity and alopecia type.ConclusionsWe recommend that gender and individual differences in anxiety‐related dimensions be considered as key factors in gaining a deeper understanding of hair loss impact on quality of life as well as in reducing the burden of illness in alopecia‐affected patients.
Exporting firms and retail internationalization: Evidence from France
Authors: Cheptea Angela , Emlinger Charlotte , Latouche Karine 
Published: November 2018

AbstractThis paper questions the impact of the globalization of the retail sector on the export activity of origin country agri‐food firms. We use an original firm‐level database of French agri‐food exports that identifies the domestic suppliers of French retailers through certification with the private International Featured Standard (IFS). The results show that IFS certified French firms are more likely to export and export larger volumes than noncertified firms to markets where French retailers have established outlets. We also show that when French retailers stop their activities in a market, certified firms reduce their exports to this market in the following years. The results are robust to the use of different sets of firm‐year‐ and country‐year‐specific controls and fixed effects, and are not affected by possible selection and endogeneity biases. The difference in the behavior of certified and noncertified exporting firms on markets where French retailers operate confirms the network effect that benefits retailers’ suppliers, which is lost when French retailers exit from the destination country.
Effect of screw access hole design on the fracture resistance of implant‐supported zirconia‐based restorations
Authors: Saboury Abolfazl , Mahshid Minoo , Tabatabaian Farhad , Moghadam Leila 
Published: November 2018

AbstractObjectiveTo evaluate the effect of screw access hole design on the fracture resistance of cement‐retained implant‐supported zirconia‐based restorations with screw access holes.Materials and MethodsThirty cement‐retained implant‐supported zirconia‐based molar crown specimens were fabricated. The specimens were divided into 3 groups of 10: without access holes (C), with screw access holes (S), and with screw access holes accompanied with a surrounding zirconia wall (W). The veneering ceramic thickness was 0.8 mm in all groups. Implants were vertically mounted in a metal block. Abutments were screwed on the implants and the specimens were cemented to the abutments. A universal testing machine applied compressive forces to the specimens until fracture. Fracture resistance values of the specimens were measured. One‐way analysis of variance (ANOVA) and Tukey HSD tests were used to analyze data (P < .05).ResultsThe mean fracture resistance values were 5794.85 N for C, 2691.48 N for S, and 3878.06 N for W. The screw access hole design significantly affected the fracture resistance (P < .0001). Significant differences were found between C and S (P < .001), C and W (P < .001), and S and W (P = .026).ConclusionsThe screw access hole decreased the fracture resistance. A surrounding zirconia wall for the screw access hole increased the fracture resistance.Clinical SignificanceScrew access hole design may affect the fracture resistance of cement‐retained implant‐supported zirconia‐based restorations with screw access holes. This study introduced a screw access hole design to improve the fracture resistance of these restorations.
Optical properties and colorimetric evaluation of resin cements formulated with thio‐urethane oligomers
Authors: Bacchi Atais , Caldas Ricardo Armini , Cesar Paulo Francisco , Pfeifer Carmem Silvia 
Published: November 2018

AbstractObjectiveThe aim of this study was to evaluate the color parameters and optical properties of resin cements (RCs) formulated with thio‐urethanes (TUs).Materials and methodsSix TUs were synthesized by combining thiols (pentaerythritol tetra‐3‐mercaptopropionate [PETMP] or trimethylol‐tris‐3‐mercaptopropionate [TMP]) with di‐functional isocyanates (1,6‐Hexanediol‐diissocyante [HDDI] [aliphatic‐AL] or 1,3‐bis(1‐isocyanato‐1‐methylethyl) benzene [BDI] [aromatic‐AR] or Dicyclohexylmethane 4,4′‐Diisocyanate [HMDI] [cyclic‐CC]). TUs (20 wt%) were added to a BisGMA/UDMA/TEGDMA matrix. Filler was introduced at 60 wt%. Fluorescence was evaluated through an UV‐light emitting equipment. Coordinates L*, a*, and b* were obtained in the black and white reflectance to evaluate the contrast ratio (CR) and translucency parameter (TP00). The coordinates obtained from transmittance were used to evaluate lightness (L*), chroma (C*), color difference (ΔE00) after 6 month, and whiteness index for Dentistry (WID).ResultsRCs formulated with TUs presented significantly higher CR, and fluorescence (with T_AR). Significantly lower C*, L*, and TP00 (except for P_AR and T_AL) were also observed in RCs containing TUs. ΔE00 were not significant among the materials. WID was not influenced.ConclusionRCs composed by TU oligomers present higher CR and lower translucency. The material also present higher fluorescence depending on the oligomer used.Clinical SignificanceThe use of thio‐urethanes to formulate resin cements can ensure a luting material with improved potential to mask colored substrates due to the higher contrast ratio and lower translucency obtained. A final higher fluorescence of restoration is also expected with the use of specific oligomer.
Structural equation modeling of home food safety practice based on the PRECEDE model
Authors: Esfarjani Fatemeh , Mohammadi‐Nasrabadi Fatemeh , Khaksar Ramin , Roustaee Roshanak , Alikhanian Haleh , Ghazi‐Tabatabaei Mahmoud , Hosseini Hedayat 
Published: November 2018

AbstractThis cross‐sectional study is the first attempt to design predictive model of home food safety practice by structural equation modeling (SEM) approach. The most important factors in the final model were demographic status (t = 1.99, γ = 0.99) and reinforcing factors (t = 3.30, γ = 0.29), while enabling factors (t = −2.07, γ = −0.10) and demographic status (t = −4.03, γ = −0.13) had reverse effect on food insecurity (FI). FI itself had negative effect on food safety practice (t = −2.21, γ = −0.16). The fit indices indicated that the model had good fitting (root mean square error of approximation [RMSEA] = 0.036, goodness of fit index [GFI] = 0.94, and adjusted goodness of fit index [AGFI] = 0.92).Practical applicationsFI and undesirable food practice were relatively prevalent among the households of Tehran. This model provides accurate and reliable information for policy makers to improve food safety status and reduce foodborne disease in Iranian households.