bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enfoque constructivista en el aprendizaje de la asignatura de metodología de la investigación en la ENEO.
Authors: Salcedo Álvarez Rey Arturo , Alba Leonel Adela , Zarza Arizmendi María Dolores 
Published: January 2019

Introducción: El aprendizaje de la investigación en enfermería generalmente se realiza a través de una educación de tipo tradicional. La enseñanza con enfoque constructivista favorecen el aprendizaje significativo y la innovación de la práctica investigativa de los problemas inherentes al cuidado. Objetivo: Realizar un diagnóstico sobre la aplicación del enfoque constructivista en el aprendizaje de la asignatura de metodología de la investigación. Metodología: Estudio de investigación educativa de tipo transversal realizado a través de una encuesta donde se exploraron cinco áreas sobre la aplicación del enfoque constructivista en el aprendizaje de la asignatura de metodología de la investigación. Resultados: Durante la primera semana de diciembre de 2008, se aplicaron 116 encuestas; el análisis de ellas, mostró que la distribución percentilar del indicador de puntuación general para el aprendizaje constructivista acumulo las frecuencias más altas para las respuestas de "casi siempre" percentil 0.25 (42), mediana (48) y percentil 0.75 (54); para la respuesta "siempre" percentil 0.25 (44), mediana (49) y percentil 0.75 (51). Discusión: Acorde a la literatura la concepción constructivista implica, la disposición total por parte del alumno y la guía del profesor en la dinámica de la enseñanza misma que si se dio en la enseñanza de esta asignatura. Conclusiones: De acuerdo con los resultados, los docentes de los grupos estudiados que imparten la asignatura de metodología de la investigación si utilizan un enfoque de constructivista.
Prevalencia de migraña y análisis de factores asociados en estudiantes de medicina colombianos
Authors: Salazar Espinosa Juan Felipe , Cardona Ramírez Jhojan Danilo , Perez Agudelo Juan Manuel 
Published: January 2019

RESUMEN
Objetivo: Determinar la prevalencia de migraña en estudiantes de medicina colombianos y su correlación con variables sociodemográficas y clínicas. Materiales y métodos: Estudio descriptivo y transversal, desarrollado en 49 universidades colombianas. Se incluyeron 299 estudiantes de medicina de primer a decimotercer semestre. Se aplicó un instrumento que contenía el autocuestionario validado ALCOI-95. Resultados: 69,6% de los sujetos fueron mujeres. La media de edad fue de 20,6 años. El 17,1% cursaba V semestre. La prevalencia de cefalea fue de 97,7% y la prevalencia de migraña de 72,5%, predominando en las mujeres (71,9%), la prevalencia fue mayor en III, V y VIII semestre, existiendo una diferencia estadísticamente significativa. No se encontró una relación estadísticamente significativa entre las variables evaluadas y los criterios ALCOI-95. Conclusión: El presente estudio resalta la elevada prevalencia de migraña en los estudiantes de medicina colombianos y la frecuencia de factores relacionados coexistentes como consumo de alcohol, tabaquismo y estrés psicológico.
Palabras Clave: Trastornos Migrañosos; Estudiantes de medicina; Migraña con Aura.
PERANCANGAN E-MARKETING UMKM KERAJINAN TAS
Authors: Susanti Nanik 
Published: January 2019

Perkembangan teknologi, dunia digital dan internet berdampak kuat pada dunia pemasaran. Diciptakannya teknologi e-marketing sebagai salah satu strategi pemasaran yang mampu menjangkau jaringan masyarakat luas. Perancangan e-marketing dalam penelitian ini ditujukan kepada usaha mikro, kecil dan menengah pengrajin tas yang tergabung dalam KUB Valya Bags di Desa Gulang. Permasalahan yang dihadapi oleh para pengrajin adalah minimnya strategi pengembangan usaha, masih menggunakan sistem traditional marketing. Jangkauan pasar sempit, Keterbatasan media promosi serta keluhan calon pembeli yang merasa kesulitan untuk mengetahui detail produk tas. Metode penelitian yang dilakukan dengan menganalisa kebutuhan yang dapat menghasilkan pemodelan sistem pemasaran dengan menggunakan perancangan sistem UML. Penelitian ini menghasilkan sebuah analisa dan perancangan e- marketing bagi UMKM pengrajin Tas di Desa Gulang yang diharapkan mampu menjangkau pasar yang lebih luas, jumlah konsumen meningkat serta dapat menjalin hubungan interaksi penjual dan pembeli tanpa dibatasi ruang dan waktu yang pada akhirnya dapat meningkatkan perekonomian masyarakat khusunya para pengrajin tas. Sistem yang dibangun meghasilkan aplikasi website untuk pemasaran produk tas yang diproduksi oleh KUB Valya Bags. Aplikasi website dapat diakses melalui URL http://www.valyabags.online. Kata kunci: strategi pemasaran, e-marketing, kerajinan tas.
FINTECH SEBAGAI SALAH SATU SOLUSI PEMBIAYAAN BAGI UMKM
Authors: Rizal Muhamad , Maulina Erna , Kostini Nenden 
Published: January 2019

ABSTRACTIn 2017, more than 40 new fintech businesses is born, this financial business have emerged that have tried their luck in the Indonesian financial landscape along with the other 140s of startup that have stood before. Indonesia's fintech industry has become one of the prima donna that attracted so much attention from the financial industry actors. Investment on startup fintech began to attract a lot of interest, even some startup managed to get series A of investment this year. The fintech sectors are beginning to develop and many new products are launched.Meanwhile, the Ministry of Cooperatives and Small and Medium Enterprises (Ministry of Small and Medium Enterprises) launched 3.79 million micro, small and medium enterprises (SMEs) already utilizing online platform in marketing their products. This number is around 8 percent of the total perpetrators of SMEs in Indonesia, which is 59.2 million.The problem of sources of financing is a classic problem that is a barrier to the growth of SMEs who do not get financing facilities from the banking sector. Lack of financial resources makes SMEs unable to develop innovations to increase production. However, the rapid growth of financing business of fintech, such as peer-to-peer lending can now be another alternative for loan fund raisers. peer-to-peer lending is a financing business that targets the middle to lower market sectors ABSTRAKSepanjang tahun 2017, setidaknya muncul lebih dari 40 bisnis fintech baru yang mencoba peruntungan di lanskap keuangan Indonesia bersama dengan 140-an startup lain yang telah berdiri sebelumnya. Industri fintech Indonesia memang menjadi salah satu primadona yang menarik perhatian begitu besar dari para pelaku industri keuangan. Investasi pada startup fintech mulai banyak diminati, bahkan beberapa startup berhasil mendapatkan investasi seri A di tahun ini. Sektor-sektor fintech mulai berkembang dan produk-produk baru banyak diluncurkan.Sementara itu, Kementerian Koperasi dan Usaha Kecil Menengah (Kemenkop UKM) melansir sebanyak 3,79 juta usaha mikro, kecil, dan menengah (UMKM) sudah memanfaatkan platform online dalam memasarkan produknya. Jumlah ini berkisar 8 persen dari total pelaku UMKM yang ada di Indonesia, yakni 59,2 juta.Masalah sumber pembiayaan merupakan masalah klasik yang menjadi penghambat pertumbuhan UMKM yang tidak mendapat fasilitas pembiayaan dari sektor perbankan. Kurangnya sumber dana menjadikan UMKM tidak dapat mengembangkan inovasi untuk meningkatkan produksinya. Namun demikian pesatnya pertumbuhan bisnis pembiayaan FinTech seperti peer-to-peer lending sekarang ini bisa menjadi alternatif lain bagi para pencari dana pinjaman. peer-to-peer lending merupakan bisnis pembiayaan yang menyasar sektor pasar menengah ke bawah.
Praćenje vršnog ekspiratornog protoka u dijagnozi profesionalne astme
Authors: Skroza Dina , Macan Jelena 
Published: January 2019

Abstract
Prema podacima iz Registra profesionalnih bolesti Hrvatskoga zavoda za zaštitu zdravlja i sigurnost na radu, u posljednjih deset godina (2008. ‒ 2017.) prijavljeno je samo 20 slučajeva profesionalne astme od ukupno 2234 prijavljene profesionalne bolesti. To upućuje na značajne nedostatke u prepoznavanju toga poremećaja u našoj radnoj populaciji. Cilj ovoga rada bio je opisati standardnu metodu praćenja vršnog ekspiratornog protoka zraka (eng. peak expiratory flow, PEF) i predložiti praktičnu smjernicu za korištenje te dijagnostičke metode u ambulantama medicine rada i sporta. Praćenje vršnog ekspiratornog protoka zraka (PEF-monitoring) jednostavna je, jeftina, neinvazivna i pouzdana metoda za utvrđivanje funkcije dišnog sustava u stvarnim uvjetima rada i radnog okoliša. Sadašnje smjernice preporučuju PEF-monitoring kao inicijalnu dijagnostičku metodu prilikom sumnje na profesionalnu astmu. Pozitivan test upozorava na povezanost promjene plućne funkcije s radnom izloženošću i važan je dio dijagnostičkoga procesa utvrđivanja profesionalne astme. Najveći je nedostatak te metode da se tim testom ne može utvrditi uzrok astme, tj. on ne razlikuje profesionalnu astmu od astme pogoršane na radu, nema standardizirane metode za interpretaciju rezultata, a mjerenja provode sami radnici pa su moguće namjerne i nenamjerne manipulacije rezultatima mjerenja. U radu je predložena praktična smjernica za primjenu te metode u ambulantama medicine rada i sporta, s preporukama protokola mjerenja PEF-a, prikaza rezultata mjerenja i njihove interpretacije u sklopu dijagnosticiranja profesionalne astme.
Sodium-glucose cotransporters: new targets of cancer therapy?
Authors: Madunić Ivana Vrhovac , Madunić Josip , Breljak Davorka , Karaica Dean , Sabolić Ivan 
Published: January 2019

Abstract
Glucose, the key source of metabolic energy, is imported into cells by two categories of transporters: 1) facilitative glucose transporters (GLUTs) and 2) secondary active sodium-glucose cotransporters (SGLTs). Cancer cells have an increased demand for glucose uptake and utilisation compared to normal cells. Previous studies have demonstrated the overexpression of GLUTs, mainly GLUT1, in many cancer types. As the current standard positron emission tomography (PET) tracer 2-deoxy-2-(18F)fluoro-D-glucose (2-FDG) for imaging tumour cells via GLUT1 lacks in sensitivity and specificity, it may soon be replaced by the newly designed, highly sensitive and specific SGLT tracer α-methyl-4-(F-18)fluoro-4-deoxy-Dglucopyranoside (Me-4FDG) in clinical detection and tumour staging. This tracer has recently demonstrated the functional activity of SGLT in pancreatic, prostate, and brain cancers. The mRNA and protein expression of SGLTs have also been reported in colon/colorectal, lung, ovarian, head, neck, and oral squamous carcinomas. So far, SGLTs have been poorly investigated in cancer, and their protein expression and localisation are often controversial due to a lack of specific SGLT antibodies. In this review, we describe current knowledge concerning SGLT1 and SGLT2 (over)expression in various cancer types. The findings of SGLTs in malignant cells may help in developing novel cancer therapies with SGLT2 or SGLT1/SGLT2 inhibitors already used in diabetes mellitus treatment.
Insert a Root to Extract a Root of Quintic Quickly
Authors: Kulkarni Raghavendra G. 
Published: January 2019

Abstract
The usual way of solving a solvable quintic equation has been to establish more equations than unknowns, so that some relation among the coefficients comes up, leading to the solutions. In this paper, a relation among the coefficients of a principal quintic equation is established by effecting a change of variable and inserting a root to the quintic equation, and then equating odd-powers of the resulting sextic equation to zero. This leads to an even-powered sextic equation, or equivalently a cubic equation; thus one needs to solve the cubic equation.
We break from this tradition, rather factor the even-powered sextic equation in a novel fashion, such that the inserted root is identified quickly along with one root of the quintic equation in a quadratic factor of the form, u
2
− g
2 = (u + g)(u − g). Thus there is no need to solve any cubic equation. As an extra benefit, this root is a function of only one coefficient of the given quintic equation.
Three-dimensional pulmonary monitoring using focused electrical impedance measurements
Authors: Orschulik Jakob , Pokee Diana , Menden Tobias , Leonhardt Steffen , Walter Marian 
Published: January 2019

Abstract
Lung pathologies such as edema, atelectasis or pneumonia are potentially life threatening conditions. Especially in critically ill and mechanically ventilated patients, an early diagnosis and treatment is crucial to prevent an Acute Respiratory Distress Syndrome [1]. Thus, continuous monitoring tool for the lung condition available at the bedside would be highly appreciated. One concept for this is Electrical Impedance Tomography (EIT). In EIT, an electrode belt of typically 16 or 32 electrodes is attached at the body surface and multiple impedance measurements are performed. From this, the conductivity change inside the body is reconstructed in a two-dimensional image. In various studies, EIT proved to be a useful tool for quantifying recruitment maneuvers, the assessment of the ventilation homogeneity, the detection of lung edema or perfusion monitoring [2, 3, 4, 5]. Nevertheless, the main problem of EIT is the low spatial resolution (compared to CT) and the limitation to two dimensional images. In this paper, we try to address the latter issue: Instead of projecting conductivity changes onto a two-dimensional image, we adjust electrode positions to focus single tetrapolar measurements to specific, three-dimensional regions of interest. In earlier work, we defined guidelines to achieve this focusing [6, 7]. In this paper, we demonstrate in simulations and in a water tank experiment that applying these guidelines can help to detect pathologies in specific lung regions.
A single differential equation description of membrane properties underlying the action potential and the axon electric field
Authors: Melendy Robert F. 
Published: January 2019

Abstract
In a succession of articles published over 65 years ago, Sir Alan Lloyd Hodgkin and Sir Andrew Fielding Huxley established what now forms our physical understanding of excitation in nerve, and how the axon conducts the action potential. They uniquely quantified the movement of ions in the nerve cell during the action potential, and demonstrated that the action potential is the result of a depolarizing event across the cell membrane. They confirmed that a complete depolarization event is followed by an abrupt increase in voltage that propagates longitudinally along the axon, accompanied by considerable increases in membrane conductance. In an elegant theoretical framework, they rigorously described fundamental properties of the Na+ and K+ conductances intrinsic to the action potential.
Notwithstanding the elegance of Hodgkin and Huxley’s incisive and explicative series of discoveries, their model is mathematically complex, relies on no small number of stochastic factors, and has no analytical solution. Solving for the membrane action potential and the ionic currents requires integrations approximated using numerical methods. In this article I present an analytical formalism of the nerve action potential, Vm
and that of the accompanying cell membrane electric field, Em
. To conclude, I present a novel description of Vm
in terms of a single, nonlinear differential equation. This is an original stand-alone article: the major contribution is the latter, and how this description coincides with the cell membrane electric field. This work has necessitated unifying information from two preceding papers [1,2], each being concerned with the development of closed-form descriptions of the nerve action potential, Vm
.
Measurement of cerebral blood flow autoregulation with rheoencephalography: a comparative pig study
Authors: Bodo Michael , D. Montgomery Leslie , J. Pearce Frederick , Armonda Rocco 
Published: January 2019

Abstract
Neuromonitoring is performed to prevent further (secondary) brain damage by detecting low brain blood flow following a head injury, stroke or neurosurgery. This comparative neuromonitoring study is part of an ongoing investigation of brain bioimpedance (rheoencephalography-REG) as a measuring modality for use in both civilian and military medical settings, such as patient transport, emergency care and neurosurgery intensive care. In a previous animal study, we validated that REG detects cerebral blood flow autoregulation (CBF AR), the body’s physiological mechanism that protects the brain from adverse effects of low brain blood flow (hypoxia/ischemia). In the current descriptive pig study, the primary goal was to compare measurements of CBF AR made with REG to measurements made with other neuromonitoring modalities: laser Doppler flow (LDF); intracranial pressure (ICP); absolute CBF; carotid flow (CF); and systemic arterial pressure (SAP). Challenges administered to anesthetized pigs were severe induced hemorrhage (bleeding) and resuscitation; CO2 inhalation; and positive end expiratory pressure (PEEP). Data were stored on a computer and processed offline. After hemorrhage, the loss of CBF AR was detected by REG, ICP, and CF, all of which passively followed systemic arterial SAP after bleeding. Loss of CBF AR was the earliest indicator of low brain blood flow: loss of CBF AR occurred before a decrease in cardiac output, which is the cardiovascular response to hemorrhage. A secondary goal of this study was to validate the usefulness of new automated data processing software developed to detect the status of CBF AR. Both the new automated software and the traditional (observational) evaluation indicated the status of CBF AR. REG indicates the earliest breakdown of CBF AR; cessation of EEG for 2 seconds and respiration would be used as additional indicators of loss of CBF AR. The clinical significance of this animal study is that REG shows potential for use as a noninvasive, continuous and non-operator dependent neuromonitor of CBF AR in both civilian and military medical settings. Human validation studies of neuromonitoring with REG are currently in progress.
Use of a conical conducting layer with an electrical impedance probe to enhance sensitivity in epithelial tissues
Authors: Kadir Muhammad Abdul , Rabbani K. Siddique-e 
Published: January 2019

Abstract
Tetra-polar electrical impedance measurement (TPIM) with a square geometry of electrodes is useful in the characterization of epithelial tissues, especially in the detection of cervical cancer at precancerous stages. However, in TPIM, the peak planar sensitivity just below the electrode surface is almost zero and increases to a peak value at a depth of about one third to one half of the electrode separation. To get high sensitivity for the epithelial layer, having thicknesses of 200 μm to 300 μm, the electrode separation needed is less than 1 mm, which is difficult to achieve in practical probes. This work proposes a conical conducting layer in front of a pencil like probe with a square geometry of TPIM electrodes to create virtual electrodes with much smaller separation at the body surface, thus increasing the sensitivity of the epithelial tissues. To understand the improvements, if any, 3D sensitivity distribution and transfer impedance were simulated using COMSOL Multiphysics software for a simplified body tissue model containing a 300 μm epithelial layer. It has been shown that fractional contribution of an epithelial layer can be increased several times placing a cylindrical conducting layer in between the tissue surface and the electrodes, which can further be enhanced using a conical conducting layer. The results presented in this paper can be used to choose an appropriate electrode separation, conducting layer height and cone parameters for enhanced sensitivity in the epithelial layer.
Nanostructured device based on coated ZnO layer as a window in solar cell applications
Authors: Mokhtari H. , Benhaliliba M. , Boukhachem A. , Aida M.S. , Ocak Y.S. 
Published: January 2019

Abstract
This work highlights some physical properties related to the influence of aluminum, tin and copper incorporation on nanostructured zinc oxide (ZnO:M; M:Al, Sn and Cu) thin films prepared by ultrasonic spray pyrolysis technique (USP) on glass substrate at 350±5 °C. For the as-grown layers, M- to Zn-ratio was fixed at 1.5 %. The effects of metal doping on structural, morphological, optical and electrical properties were investigated. X-ray diffraction pattern revealed that the as-prepared thin films crystallized in hexagonal structure with (0 0 2) preferred orientation. The surface topography of the films was performed by atomic force microscopy. AFM images revealed inhibition of grain growth due to the doping elements incorporation into ZnO matrix, which induced the formation of ZnO nanoparticles. Optical measurements showed a high transparency around 90 % in visible range. Some optical parameters, such as optical band gap, Urbach energy, refractive index, extinction coeffi-cient and dielectric constant were studied in terms of doping element. Particularly, dispersion of refractive index was discussed in terms of both Cauchy and single oscillator model proposed by Wemple and DiDomenico. Cauchy parameters and single oscillator energy E0 as well as dispersion energy Ed were calculated. Finally, electrical properties were investigated by means of electrical conductivity and Hall effect measurements. The measurements confirmed n type conductivity of the prepared thin films and a good agreement between the resistivity values and the oxidation number of doping element. The main aim of this work was the selection of the best candidate for doping ZnO for optoelectronics applications. The comparative study of M doped ZnO (M:Al, Sn and Cu) was performed. High rectifying efficiency of the Al/n-ZnO/p-Si/Al device was achieved and non-ideal behavior was revealed with n > 4.
The relationship between the TSH values and the Tpeak – Tend interval duration in hypothyroid patients receiving Levothyroxine treatment
Authors: Findikli Hüseyin Avni , Tutak Ayşe Şahin , Aydin Hakan 
Published: January 2019

Abstract

Introduction
. Changes in thyroid hormone level can affect the cardiovascular system. The aim of this study was to show how the Tpeak -Tend (Tpe) interval, which is a new marker of ventricular arrythmia, is affected in patients who have become euthyroid following Levothyroxine treatment for hypothyroidism, as this has not been examined previously in literature.

Materials and Methods
. This, cross-sectional study included a total of 119 females aged 18-45 years, separated into 3 groups as hypothyroid, euthyroid and control groups. For evaluation of the QTc and Tpe intervals, examination on precordial V5 lead was made of all the ECGs taken routinely on presentation of the patients.

Results
. The Tpe and QTc intervals of the hypothyroid group were determined to be significantly prolonged compared to those of the euthyroid and control groups (p < 0.001) and the values of the euthyroid and control groups were similar. A positive correlation was determined between TSH levels and Tpe and QTc intervals. Tpe interval AUC = 0.801 (%95 CI: 0.719 – 0.884) was higher than that of QTc AUC = 0.689 (%95 CI: 0.591 – 0.786).

Conclusions
. The Tpe duration was evaluated in respect of the risk of arrythmia in hypothyroid patients. In patients who had become euthyroid, the Tpe interval was found to be similar to that of healthy individuals and was more predictive than QTc. In the light of these findings it can be recommended that measurement of the Tpe interval should be preferred to QTc as a marker of the arrythmogenic effect in hypothyroid patients.