bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of NOSE Scores Following Functional Septorhinoplasty Using Autologous versus Cadaveric Rib
Authors: Fuller Jennifer , Levesque Patricia , Lindsay Robin , Justicz Natalie 
Published: January 2019

AbstractIn functional septorhinoplasty (FSRP), alternative grafting material is used if septal cartilage is insufficient for reconstructive needs. Autologous costal cartilage (ACC) and irradiated homologous costal cartilage (IHCC) are compared via the Nasal Obstruction Symptom Evaluation (NOSE) scale. One-hundred forty-one patients who underwent FSRP with ACC or IHCC between January 2013 and March 2018 were administered the NOSE scale pre- and postoperatively at 2, 4, 6, and 12 months. There was no significant difference in mean NOSE scores between the ACC and IHCC cohorts at the preoperative visit (68.5 [standard deviation, SD 24.1] and 71.7 [20.1], respectively; p < 0.6) or first postoperative visit (30.4 [26.6] and 33.9 [30.4], respectively; p < 0.6) or subsequent visits. NOSE scores demonstrated a clinically and statistically significant improvement at all follow-up time points for both the ACC and IHCC groups. Patients who underwent grafting with IHCC were significantly older than those with ACC; average age of 55.6 [SD: 17.3] versus 40.1 [SD:12.1]; (p < 0.001). Two IHCC (0.05%) patients had postoperative infections; both resolved with antibiotics, but one required revision surgery. Both ACC and IHCC provide reliable grafting material when septal cartilage is insufficient. In FSRP for nasal airway obstruction, ACC and IHCC both provide a clinically and statistically significant reduction in NOSE scores postoperatively that remain stable between follow-up time points. The authors find no difference in NOSE scores between the ACC and IHCC groups; however, IHCC did have a higher rate of postoperative infection. Both materials should be discussed with patients and are an important part of the informed consent process.
Role of Ultrasound in Diagnosis of Fetus Acardius Acephalus in Multiple Pregnancies
Authors: Yadav Ruby , Choudhary Nishi 
Published: January 2019

AbstractThis case report describes an acardiac fetus of the acephalus phenotype in a triplet pregnancy. The diagnosis was confirmed at 13 weeks. In the absence of signs of heart failure in the co-fetus, the pregnancy was managed conservatively. The pregnancy was complicated by preterm labor and the fetuses were delivered at 23 + 4 weeks. Also, the perinatal outcomes of triplet pregnancies complicated by an acardiac fetus, where the median gestational age at delivery is 23 to 24 weeks, are summarized, and the possible therapeutic interventions have been discussed.
A Systematic Review of Resident Aesthetic Clinic Outcomes
Authors: Kaplan Jordan , Volk Angela S , Ashley Janet R , Izaddoost Shayan , Reece Edward , Winocour Sebastian 
Published: January 2019

Abstract

Background
Providing residents with comprehensive training in aesthetic surgery has proven challenging. Resident aesthetic clinics propose an educational value to trainees while providing successful patient outcomes.

Objectives
This study systematically reviewed the available literature regarding resident aesthetic clinic outcomes to determine the efficacy of the clinic in resident training, surgical results, and patient satisfaction.

Methods
An electronic database search was performed to identify literature reporting on resident aesthetic clinics. Studies were excluded if the resident clinic was not aesthetic in nature, if only nonsurgical aesthetic procedures were performed, and if clinic outcomes were not evaluated. Study quality was assessed using the Newcastle Ottawa Scale for nonrandomized studies.

Results
Ten of 148 identified studies met inclusion criteria; 2 utilized a survey, 3 were retrospective cohort studies, and 5 were retrospective cohort studies also utilizing a survey. Clinic schedules, surgical case volume, and surgical procedures performed all varied. One study received a Newcastle Ottawa Scale score of 7 of a possible 9 stars, 2 studies received 5 stars, 5 studies received 4 stars, and 2 could not be assessed using the scoring system. Six studies analyzed surgical results as a primary outcome, reporting acceptable complication and revision rates. Four studies evaluated patient opinions of the clinics and reported overall high satisfaction rates.

Conclusions
This systematic review suggests that resident aesthetic clinics enhance resident education while providing safe and successful surgical results to patients.
Antimicrobial prophylaxis and the prevention of surgical site infection in cardiac surgery: an analysis of 21 007 patients in Switzerland†
Authors: Sommerstein Rami , Atkinson Andrew , Kuster Stefan P , Thurneysen Maurus , Genoni Michele , Troillet Nicolas , Marschall Jonas , Widmer Andreas F ,   Swissnoso, Balmelli Carlo , Eisenring Marie-Christine , Harbarth Stephan , Kuster Stefan P , Marschall Jonas , Spicher Virginie Masserey , Pittet Didier , Ruef Christian , Sax Hugo , Schlegel Matthias , Schweiger Alexander , Troillet Nicolas , Widmer Andreas F , Zanetti Giorgio 
Published: January 2019

AbstractOBJECTIVES:Our goal was to determine the optimal timing and choice of surgical antimicrobial prophylaxis (SAP) in patients having cardiac surgery.METHODS:The setting was the Swiss surgical site infection (SSI) national surveillance system with a follow-up rate of >94%. Participants were patients from 14 hospitals who had cardiac surgery from 2009 to 2017 with clean wounds, SAP with cefuroxime, cefazolin or a vancomycin/cefuroxime combination and timing of SAP within 120 min before the incision. Exposures were SAP timing and agents; the main outcome was the incidence of SSI. We fitted generalized additive and mixed-effects generalized linear models to describe effects predicting SSIs.RESULTS:A total of 21 007 patients were enrolled with an SSI incidence of 5.5%. Administration of SAP within 30 min before the incision was significantly associated with decreased deep/organ space SSI [adjusted odds ratio (OR) 0.73, 95% confidence interval (CI) 0.54–0.98; P = 0.035] compared to administration of SAP 60–120 min before the incision. Cefazolin (adjusted OR 0.64, 95% CI 0.49–0.84; P = 0.001) but not vancomycin/cefuroxime combination (adjusted OR 1.05, 95% CI 0.82–1.34; P = 0.689) was significantly associated with a lower risk of overall SSI compared to cefuroxime alone. Nevertheless, there were no statistically significant differences between the SAP agents and the risk of deep/organ space SSI.CONCLUSIONS:The results from this large prospective study provide substantial arguments that administration of SAP close to the time of the incision is more effective than earlier administration before cardiac surgery, making compliance with SAP administration easier. The choice of SAP appears to play a significant role in the prevention of all SSIs, even after adjusting for confounding variables.
The impact of agri-environment schemes on farm productivity: a DID-matching approach
Authors: Mennig Philipp , Sauer Johannes 
Published: January 2019

AbstractAccording to WTO standards, agri-environmental schemes (AES) payments should distort neither trade nor production but instead only compensate for income forgone and costs incurred. At the same time, contract design shall give farmers enough flexibility to react to changing market and production conditions. We apply a difference-in-difference propensity score matching estimator to test if AES have an unintended effect on farm productivity. Our results suggest that schemes designed for arable land overcompensate farmers and thus do fail to comply with WTO rules. For dairy farms, we find that AES participation reduces farm productivity, implying that action-based scheme design not considering changing market and production situations might be too restrictive, potentially preventing farmers from participating.
The effect of off-hour delivery on severe maternal morbidity: a population-based cohort study
Authors: Nam Jin Young , Lee Sang Gyu , Nam Chung Mo , Park Sohee , Jang Sung In , Park Eun-Cheol 
Published: January 2019

AbstractBackgroundSevere maternal morbidity is an indicator for quality of maternal care. Recently, there has been growing interest in identifying which provision factors affect the quality of maternity care. The extent to off-hour delivery on SMM rates contributes to individual or provision factor in Korea has not been studied. This study aimed to determine the relationship between off-hour delivery and SMM during childbirth hospitalization.MethodsThis is a population-based retrospective cohort study. Data were extracted from the Korean National Health Insurance Service-National Sample Cohort for 90 072 cases of delivery in Korea between 2003 and 2013. The main outcome was SMM which was determined using the Center for Disease Control and Prevention’s algorithm. A generalized estimating equation model with log link was performed for the relationship with SMM and day/time of delivery adjusted covariates.ResultsOf the 90 072 delivery cases, 2085 (2.31%) had SMM. Women who were on weekdays at night time or on weekend delivery had a higher risk of SMM compared with those who were on weekdays at daytime (RR 1.26, 95% CI 1.10–1.46, and RR 1.58, 95% CI 1.30–1.93, respectively).ConclusionWeekday at night time or weekend delivery was related to the risk of SMM. Policymakers should provide financial support and systematically allocate adequate human resources and labour facilities in vulnerable areas, as well as during weekends and night times to improve the quality of intrapartum and postpartum maternity care.
SMAGEXP: a galaxy tool suite for transcriptomics data meta-analysis
Authors: Blanck Samuel , Marot Guillemette 
Published: January 2019

Abstract

Background
With the proliferation of available microarray and high-throughput sequencing experiments in the public domain, the use of meta-analysis methods increases. In these experiments, where the sample size is often limited, meta-analysis offers the possibility to considerably enhance the statistical power and give more accurate results. For those purposes, it combines either effect sizes or results of single studies in an appropriate manner. R packages metaMA and metaRNASeq perform meta-analysis on microarray and next generation sequencing (NGS) data, respectively. They are not interchangeable as they rely on statistical modeling specific to each technology.

Results
SMAGEXP (Statistical Meta-Analysis for Gene EXPression) integrates metaMA and metaRNAseq packages into Galaxy. We aim to propose a unified way to carry out meta-analysis of gene expression data, while taking care of their specificities. We have developed this tool suite to analyze microarray data from the Gene Expression Omnibus database or custom data from Affymetrix© microarrays. These data are then combined to carry out meta-analysis using metaMA package. SMAGEXP also offers to combine raw read counts from NGS experiments using DESeq2 and metaRNASeq package. In both cases, key values, independent from the technology type, are reported to judge the quality of the meta-analysis. These tools are available on the Galaxy main tool shed. A dockerized instance of galaxy containing SMAGEXP and its dependencies is available on Docker hub. Source code, help, and installation instructions are available on GitHub.

Conclusion
The use of Galaxy offers an easy-to-use gene expression meta-analysis tool suite based on the metaMA and metaRNASeq packages.
A chromosomal-scale genome assembly of Tectona grandis reveals the importance of tandem gene duplication and enables discovery of genes in natural product biosynthetic pathways
Authors: Zhao Dongyan , Hamilton John P , Bhat Wajid Waheed , Johnson Sean R , Godden Grant T , Kinser Taliesin J , Boachon Benoît , Dudareva Natalia , Soltis Douglas E , Soltis Pamela S , Hamberger Bjoern , Buell C Robin 
Published: January 2019

Abstract

Background
Teak, a member of the Lamiaceae family, produces one of the most expensive hardwoods in the world. High demand coupled with deforestation have caused a decrease in natural teak forests, and future supplies will be reliant on teak plantations. Hence, selection of teak tree varieties for clonal propagation with superior growth performance is of great importance, and access to high-quality genetic and genomic resources can accelerate the selection process by identifying genes underlying desired traits.

Findings
To facilitate teak research and variety improvement, we generated a highly contiguous, chromosomal-scale genome assembly using high-coverage Pacific Biosciences long reads coupled with high-throughput chromatin conformation capture. Of the 18 teak chromosomes, we generated 17 near-complete pseudomolecules with one chromosome present as two chromosome arm scaffolds. Genome annotation yielded 31,168 genes encoding 46,826 gene models, of which, 39,930 and 41,155 had Pfam domain and expression evidence, respectively. We identified 14 clusters of tandem-duplicated terpene synthases (TPSs), genes central to the biosynthesis of terpenes, which are involved in plant defense and pollinator attraction. Transcriptome analysis revealed 10 TPSs highly expressed in woody tissues, of which, 8 were in tandem, revealing the importance of resolving tandemly duplicated genes and the quality of the assembly and annotation. We also validated the enzymatic activity of four TPSs to demonstrate the function of key TPSs.

Conclusions
In summary, this high-quality chromosomal-scale assembly and functional annotation of the teak genome will facilitate the discovery of candidate genes related to traits critical for sustainable production of teak and for anti-insecticidal natural products.
The Incidence and Definition of Crohn’s Disease of the Pouch: A Systematic Review and Meta-analysis
Authors: Barnes Edward L , Kochar Bharati , Jessup Hilary R , Herfarth Hans H 
Published: January 2019

AbstractBackgroundA subset of patients who undergo total proctocolectomy with ileal pouch–anal anastomosis (IPAA) creation for ulcerative colitis (UC) will later develop Crohn’s disease (CD) of the pouch, which has been associated with significant morbidity. We aimed to analyze the incidence of CD of the pouch and to review the existing diagnostic criteria utilized.MethodsA systematic search performed through March 1, 2018, identified 12 studies that reported the incidence of CD of the pouch after IPAA for UC or indeterminate colitis (IC). We compiled all diagnostic criteria utilized in these studies and then performed a meta-analysis using random effects modeling to estimate the overall incidence of CD of the pouch in this population.ResultsAmong 4843 patients with an IPAA for UC or IC, 10.3% of patients were ultimately diagnosed with CD of the pouch (95% confidence interval [CI], 6.1%–15.4%). The most commonly reported diagnostic criteria were (1) presence of fistula/fistulae, (2) stricture involving the pouch or prepouch ileum, and (3) presence of prepouch ileitis. In a secondary analysis, excluding those studies that included patients with a preoperative diagnosis of IC, the incidence of CD of the pouch was 12.4% (95% CI, 9.0%–16.1%).ConclusionsThe estimated incidence of 10.3% will assist gastroenterologists and surgeons in preoperative counseling regarding the potential to develop CD of the pouch. There is an unmet need for common diagnostic criteria for a more standardized approach to the diagnosis of CD of the pouch.
The influence of nudges on compliance behaviour in recreational fisheries: a laboratory experiment
Authors: Mackay Mary , Yamazaki Satoshi , Jennings Sarah , Sibly Hugh , van Putten Ingrid E , Emery Timothy J 
Published: January 2019

Abstract
Non-compliance is a tenacious problem in recreational fisheries management, posing a risk to marine conservation and socio-ecological systems by, for example, undermining management efforts and creating conflict between resource user groups. In fisheries management, deterrence-based approaches have traditionally been used to tackle non-compliance. However, enforcement is often limited in recreational fisheries and an alternative approach is needed to improve compliance. In this paper, we explore the lessons from behavioural economics and apply nudge theory as the basis of alternative management approaches. Nudge theory argues that through positive reinforcement or indirect suggestion, voluntary compliance can be achieved. We test the influence of a nudge, based on a descriptive social norm, through an economic laboratory experiment in a recreational fisheries context. Our results show that the presence of this nudge can increase compliance behaviour by 10%. We find that a nudge was more effective when deterrence is low, but its effects become weaker when deterrence is already high. We also find heterogeneity across individual’s responses to the nudge and risk preferences significantly related to compliance behaviour. Nudges based on social norms have the potential to complement traditional deterrence methods and could prove successful as a cost-effective compliance tool in the marine environment.
Indicators for Nonroutine Discharge Following Cervical Deformity-Corrective Surgery: Radiographic, Surgical, and Patient-Related Factors
Authors: Bortz Cole A , Passias Peter G , Segreto Frank , Horn Samantha R , Lafage Virginie , Smith Justin S , Line Breton , Mundis Gregory M , Kebaish Khaled M , Kelly Michael P , Protopsaltis Themistocles , Sciubba Daniel M , Soroceanu Alexandra , Klineberg Eric O , Burton Douglas C , Hart Robert A , Schwab Frank J , Bess Shay , Shaffrey Christopher I , Ames Christopher P ,   International Spine Study Group (ISSG)
Published: January 2019

Abstract

BACKGROUND
Nonroutine discharge, including discharge to inpatient rehab and skilled nursing facilities, is associated with increased cost-of-care. Given the rising prevalence of cervical deformity (CD)-corrective surgery and the necessity of value-based healthcare, it is important to identify indicators for nonroutine discharge.

OBJECTIVE
To identify factors associated with nonroutine discharge after CD-corrective surgery using a statistical learning algorithm.

METHODS
A retrospective review of patients ≥18 yr with discharge and baseline (BL) radiographic data. Conditional inference decision trees identified factors associated with nonroutine discharge and cut-off points at which factors were significantly associated with discharge status. A conditional variable importance table used nonreplacement sampling set of 10 000 conditional inference trees to identify influential patient/surgical factors. The binary logistic regression indicated odds of nonroutine discharge for patients with influential factors at significant cut-off points.

RESULTS
Of 138 patients (61 yr, 63% female) undergoing surgery for CD (8 ± 5 levels; 49% posterior approach, 16% anterior, and 35% combined), 29% experienced nonroutine discharge. BL cervical/upper-cervical malalignment showed the strongest relationship with nonroutine discharge: C1 slope ≥ 14°, C2 slope ≥ 57°, TS-CL ≥ 57°. Patient-related factors associated with nonroutine discharge included BL gait impairment, age ≥ 59 yr and apex of CD primary driver ≥ C7. The only surgical factor associated with nonroutine discharge was fusion ≥ 8 levels. There was no relationship between nonhome discharge and reoperation within 6 mo or 1 yr (both P > .05) of index procedure. Despite no differences in BL EQ-5D (P = .946), nonroutine discharge patients had inferior 1-yr postoperative EQ-5D scores (P = .044).

CONCLUSION
Severe preoperative cervical malalignment was strongly associated with nonroutine discharge following CD-corrective surgery. Age, deformity driver, and ≥ 8 level fusions were also associated with nonroutine discharge and should be taken into account to improve patient counseling and health care resource allocation.
Plasma Profiles of Inflammatory Markers Associated With Active Tuberculosis in Antiretroviral Therapy-Naive Human Immunodeficiency Virus-Positive Individuals
Authors: Olsson Oskar , Björkman Per , Jansson Marianne , Balcha Taye Tolera , Mulleta Daba , Yeba Habtamu , Valfridsson Christine , Carlsson Fredric , Skogmar Sten 
Published: January 2019

Abstract

Background
Diagnosis of tuberculosis (TB) in human immunodeficiency virus (HIV)-coinfected individuals is challenging. We hypothesized that combinations of inflammatory markers could facilitate identification of active TB in HIV-positive individuals.

Methods
Participants were HIV-positive, treatment-naive adults systematically investigated for TB at Ethiopian health centers. Plasma samples from 130 subjects with TB (HIV+/TB+) and 130 subjects without TB (HIV+/TB−) were tested for concentration of the following markers: CCL5, C-reactive protein (CRP), interleukin (IL)-6, IL12-p70, IL-18, IL-27, interferon-γ-induced protein-10 (IP-10), procalcitonin (PCT), and soluble urokinase-type plasminogen activator receptor (suPAR). Analyzed markers were then assessed, either individually or in combination, with regard to infection status, CD4 cell count, and HIV ribonucleic acid (RNA) levels.

Results
The HIV+/TB+ subjects had higher levels of all markers, except IL12p70, compared with HIV+/TB− subjects. The CRP showed the best performance for TB identification (median 27.9 vs 1.8 mg/L for HIV+/TB+ and HIV+/TB−, respectively; area under the curve [AUC]: 0.80). Performance was increased when CRP was combined with suPAR analysis (AUC, 0.83 [0.93 for subjects with CD4 cell count &lt;200 cells/mm3]). Irrespective of TB status, IP-10 concentrations correlated with HIV RNA levels, and both IP-10 and IL-18 were inversely correlated to CD4 cell counts.

Conclusions
Although CRP showed the best single marker discriminatory potential, combining CRP and suPAR analyses increased performance for TB identification.
Dalbavancin as Secondary Therapy for Serious Staphylococcus aureus Infections in a Vulnerable Patient Population
Authors: Bryson-Cahn Chloe , Beieler Alison M , Chan Jeannie D , Harrington Robert D , Dhanireddy Shireesha 
Published: January 2019

Abstract
We retrospectively evaluated off-label use of dalbavancin as secondary therapy in 32 patients with serious Staphylococcus aureus infections (endocarditis, osteomyelitis, septic thrombophlebitis, epidural infection) who were also persons who use drugs. The majority of patients (56%) had a clinical response to treatment. Only 1 patient who completed the intended dalbavancin course experienced a treatment failure.
Attitudes towards Data Linkage for Evidence-Based Policymaking
Authors: Fobia Aleia Clark , Holzberg Jessica , Eggleston Casey , Childs Jennifer Hunter , Marlar Jenny , Morales Gerson 
Published: January 2019

Abstract
In a recent report, the Commission for Evidence-Based Policymaking advocated for expanded use of data, including data linkage, from federal statistical and regulatory agencies to help guide decision-making and ultimately improve programs and policies. How data sharing and linkage is framed is important, and attitudes about data sharing and linkage are driven by respondents’ privacy beliefs and views towards the government more generally. Using data from the RDD telephone Gallup Daily Tracking Survey, we examine how favorability towards data sharing for the purpose of informed decision-making compares to other purposes. Respondents were less favorable towards data sharing when the purpose was for informed decision-making than for efficient use of taxpayer money, government accountability, or for community benefits, suggesting this is an ineffective way to frame data sharing to increase support. However, views towards the government, beliefs about privacy, and response behavior are still important determinants of favorability.