bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accelerated biological aging: unveiling the path to cardiometabolic multimorbidity, dementia, and mortality
Authors: He Yi , Jia Yu , Li Yizhou , Wan Zhi , Lei Yi , Liao Xiaoyang , Zhao Qian , Li Dongze 
Published: October 2024

BackgroundCardiometabolic multimorbidity (CMM) and aging are increasing public health concerns. This prospective study used UK Biobank cohort to investigate the relationship between biological aging and the trajectory of CMM to dementia and mortality.MethodsCMM is the coexistence of at least two cardiometabolic diseases (CMD), including stroke, ischemic heart disease, and diabetes. Biological age was calculated using the KDM-BA and PhenoAge algorithms. Accelerated aging indicated biological age advances more rapidly than chronological age.ResultsThe study included 415,147 individuals with an average age of 56.5 years. During the average 11-year follow-up period, CMD-free individuals with accelerated aging had a significantly greater risk of CMD (KDM-BA, HR 1.456; PhenoAge, HR 1.404), CMM (KDM-BA, HR 1.952; PhenoAge, HR 1.738), dementia (KDM-BA, HR 1.243; PhenoAge, HR 1.212), and mortality (KDM-BA, HR 1.821; PhenoAge, HR 2.047) in fully-adjusted Cox regression models (p &lt; 0.05 for all). Accelerated aging had adjusted HRs of 1.489 (KDM-BA) and 1.488 (PhenoAge) for CMM, 1.434 (KDM-BA) and 1.514 (PhenoAge) for dementia, and 1.943 (KDM-BA) and 2.239 (PhenoAge) for mortality in participants with CMD at baseline (p &lt; 0.05 for all). CMM significantly mediated accelerated aging’s indirect effects on dementia by 13.7% (KDM-BA, HR) and 21.6% (PhenoAge); those on mortality were 4.7% (KDM-BA) and 5.2% (PhenoAge). The population attributable-risk of Life’s Essential 8 score (≥80 vs. &lt;80) were 0.79 and 0.43 for KDM-BA and PhenoAge accelerated aging, respectively.ConclusionBiological aging involves the entire trajectory of CMM from a CMD-free state to CMD, to CMM, and ultimately to dementia and death. Life’s Essential 8 may be a potential target to counter age acceleration.
Exploring the impact of polychlorinated biphenyls on comorbidity and potential mitigation strategies
Authors: Gao Ying , Lu Han , Zhou Huan , Tan Jiaxing 
Published: October 2024

IntroductionPolychlorinated Biphenyls (PCBs) persist in the environment and accumulate in humans. Currently, there is a lack of understanding about the overall impact of PCBs on human health, and effective interventions for exposed populations are insufficient.MethodsOur study aimed to assess the impact of PCBs on various diseases and mortality risks using data from the National Health and Nutrition Examination Survey, while proposing lifestyle adjustments, particularly dietary modifications, to mitigate mortality risk. Statistical analyses employed principal component analysis, multifactorial logistic regression, multifactorial Cox regression, comorbidity network analysis, and machine learning prediction models.ResultsResults indicated significant associations between 7 types of PCBs and 12 diseases (p &lt; 0.05), with 6 diseases showing significant positive correlations (OR &gt; 1, p &lt; 0.05), along with listing the 25 most relevant diseases, such as asthma and chronic bronchitis (OR [95% CI] = 5.85 [4.37, 7.83], p &lt; 0.0001), arthritis and osteoporosis (OR [95% CI] = 6.27 [5.23, 7.55], p &lt; 0.0001). This suggested that PCBs may be intimately involved in the development and progression of multiple diseases. By constructing multidimensional machine learning models and conducting multiple iterations for precision and error measurement, PCBs may have the potential to become specific biomarkers for certain diseases in the future. Building upon this, we further suggested that controlling dietary intake to reduce dietary inflammatory index (DII) could lower mortality and disease risks.DiscussionWhile PCBs were independent risk factors for mortality, substantial evidence suggested that adjusting DII might mitigate the adverse effects of PCBs to some extent. Further physiological mechanisms require deeper exploration through additional research.
Occupational epidemiological characteristics of noise-induced hearing loss and the impact of combined exposure to noise and dust on workers’ hearing—a retrospective study
Authors: Zhou Bin , Zhang Jiaxiang 
Published: October 2024

IntroductionThe aim of the study was to investigate the occupational epidemiological characteristics of hearing loss among noise-exposed workers through a cross-sectional study and to explore the impact of combined noise and dust exposure on workers’ hearing loss through a longitudinal study.ResultsThis cross-sectional study revealed that the risk of speech-frequency hearing loss increases with age (OR = 1.096, 95%CI = 1.081–1.111). Independent factors influencing high-frequency hearing loss include sex, age, hazardous factors, industry category, and enterprise size. Scientific research and technical services (OR = 1.607, 95%CI = 1.111–2.324), wholesale and retail (OR = 2.144, 95%CI = 1.479–3.107), manufacturing (OR = 1.907, 95%CI = 1.429–2.545), and other industries (OR = 1.583, 95%CI = 1.002–2.502) are risk factors for high-frequency hearing loss, whereas being female (OR = 0.297, 95%CI = 0.236–0.373) is a protective factor against high-frequency hearing loss. Independent factors influencing occupational noise-induced hearing loss include sex, working age, hazardous factors, industry category, smoking, and drinking, with the risk of occupational noise-induced hearing loss increasing with working age (OR = 1.045, 95%CI = 1.031–1.058). Noise and dust work (OR = 1.271, 95%CI = 1.011–1.597), other work (OR = 0.619, 95%CI = 0.479–0.800), manufacturing (OR = 2.085, 95%CI = 1.336–3.254), other industries (OR = 2.063, 95%CI = 1.060–4.012), occasional smokers (OR = 0.863, 95%CI = 0.652–1.142), regular smokers (OR = 1.216, 95% CI = 0.987–1.497), and excessive drinkers (OR = 2.171, 95%CI = 1.476–3.193) are risk factors for occupational noise-induced hearing loss, whereas being female (OR = 0.496, 95%CI = 0.347–0.709) is a protective factor against occupational noise-induced hearing loss. The longitudinal study revealed differences in pure-tone hearing threshold test results at 500 Hz, 1,000 Hz, 3,000 Hz, 4,000 Hz, and 6,000 Hz in both ears before and after enrollment among noise-exposed workers (p &lt; 0.05). Combined noise and dust exposure (OR = 4.660, 95%CI = 1.584–13.711), 1st year (OR = 1.540, 95%CI = 1.128–2.103), 2nd year (OR = 1.994, 95%CI = 1.409–2.821), and 3rd year (OR = 1.628, 95%CI = 1.170–2.264) were risk factors for high-frequency hearing loss.DiscussionCombined noise and dust exposure is a risk factor for occupational noise-induced hearing loss. Additionally, occupational noise-induced hearing loss is influenced by gender, working age, enterprise industry category, smoking, and drinking. Employers should enhance occupational health management and improve workers’ occupational health literacy, with a particular focus on older male workers of long working age, and those with unhealthy habits. Combined exposure to noise and dust may have a synergistic effect on causing high-frequency hearing loss, and comprehensive protective measures should be implemented for workers exposed to both.
Reported roles of care partners in a specialized weaning centre—perspectives of patients, care partners, and health care providers
Authors: Istanboulian L. , Gilding A. , Hamilton L. , Master T. , Bingler S. , Hill M. , Isani S. , Kazi S. , Coppinger S. , Smith K. 
Published: October 2024

BackgroundCare partners are individuals chosen by a person with an illness to support their care during hospitalization. Patients with persistent critical illness have longer than average critical care admission and often other conditions including dysphagia, communication vulnerability, severe physical deconditioning, the need for an artificial airway, and difficulty weaning from invasive mechanical ventilation. Family presence has been identified as important for patients experiencing persistent critical illness in specialized weaning centers. Despite this, the role of care partners in clinical settings for patients with persistent critical illness has not been fully characterized, particularly from the perspectives of patients, care partners, and health care providers. The aim of this study was to gain insights into the roles of care partners during persistent critical illness from the perspectives of patients, care partners, and health care providers.MethodsWe used qualitative descriptive methodology including semi-structured interviews and content analysis. Interviews were audio recorded and transcribed verbatim. Included participants (n = 30) were patient survivors (n = 7), care partners of patient survivors (n = 9), and professionally diverse health care providers (n = 14) of adult patients with persistent critical illness from two specialized units in one community academic hospital in Toronto, Canada.ResultsParticipants across all groups described care partner roles that included physical, mental health, cognitive, social, and spiritual support of the patient, including the perceived role of safeguarding the multiple dimensions of care for the patient who is experiencing persistent critical care in specialized care settings.DiscussionThe results of this study are being used to co-design, implement, and evaluate a sustainable care partner program that is acceptable, appropriate, and feasible to implement in clinical settings where the care of patients with persistent critical illness occurs.Reporting methodConsolidated criteria for reporting qualitative studies (COREQ).
Outcome and survival analysis of pulmonary metastasectomy for primary sarcoma with pulmonary metastases
Authors: Chang Chih-Hsiang , Chiang Xu-Heng , Lin Mong-Wei , Kuo Shuenn-Wen , Huang Pei-Ming , Hsu Hsao-Hsun , Chen Jin-Shing 
Published: October 2024

BackgroundSarcomas are rare malignancies, accounting for approximately 1% of all cancers. Pulmonary metastases are the most preferential site for distant metastasis in malignant soft tissue sarcomas. Despite the lack of evidence from large randomized trials to support treatment guidelines, surgical resection of resectable metastatic tumors remains the current standard of care. This study aimed to explore the survival status of patients with soft tissue sarcoma after resection of pulmonary metastases.MethodsThis study is a retrospective analysis of patients who mestastasectomy by means of lobar or sublobar resections at National Taiwan University Hospital and its branches. The statistical and investigation period was from February 2007 to December 2020.ResultsAmong 110 samples during the investigation period, the overall 5-year survival rate was 62.9%, which was higher than the 15%–50.9% reported previously. A disease-free interval of more than 12 months and the occurrence of local recurrence of sarcoma at the time of resection of pulmonary metastases are associated with overall survival. Most of the samples were treated with minimally invasive surgery (VATS), and therefore, most patients had a shorter hospital stay and better postoperative recovery.ConclusionFor pulmonary metastatic sarcoma, pulmonary metastasectomy is a relatively safe treatment method with short hospital stay and short ICU stay. The results of this study suggest that VATS is preferred over thoracotomy, but further observations are needed to confirm these findings.
A toxicological assessment of Ganoderma lucidum and Cordyceps militaris mushroom powders
Authors: Chrysostomou Paola P. , Freeman Elaine , Murphy Mary M. , Chaudhary Ankit , Siddiqui Nazia , Daoust Julie 
Published: October 2024

Gonoderma lucidum (G. lucidum) and Cordyceps militaris (C. militaris) are among the many mushrooms known for their long history of use in traditional medicine. Wildcrafted sources of mushrooms including G. lucidum and C. militaris can be limited from a scarcity and quality perspective, but solid fermentation processes in cultivation settings can provide an efficient way to deliver whole mushroom preparations of a consistent composition. Despite the historical use of these mushrooms, few published reports have explored their potential subchronic oral toxicity or genotoxicity, either from specific components or whole mushroom preparations. The purpose of this study was to assess the potential for acute toxicity, subchronic toxicity, and genotoxicity of powders produced from G. lucidum mycelial biomass and fruiting body (“Organic Reishi M2-102-02 powder”) cultured on oats, and C. militaris mycelial biomass, stroma, and fruiting body (“Organic Cordyceps M2-116-04 powder”) cultured on oats. Results of the testing demonstrate that both Organic Reishi M2-102-02 powder and Organic Cordyceps M2-116-04 powder were not acutely toxic, did not exhibit subchronic oral toxicity in rats at doses up to the highest dose tested of 2,000 mg/kg bw/day, and did not have genotoxic potential based on in vitro and in vivo genotoxicity assays.
Prevalence and genetic evolution analysis of porcine epidemic diarrhea virus and porcine circovirus type 2 in Sichuan Province, China, from 2023 to 2024
Authors: Wu Fang , Xu Tong , Lai Si-Yuan , Ai Yan-Ru , Zhou Yuan-Cheng , Ge Liang-Peng , Sun Jing , Liu Zuo-Hua , Zeng Xiu , Lang Li-Qiao , Xu Zhi-Wen , Zhu Ling 
Published: October 2024

IntroductionPorcine circovirus type 2 (PCV2) and Porcine epidemic diarrhea virus (PEDV) are highly prevalent in Sichuan, significantly affecting the swine industry’s development. PCV2, known for its immunosuppressive effects, can compromise pigs’ immune systems, while PEDV typically causes diarrhea in piglets, leading to high mortality rates. Despite their impact, recent studies on the epidemiology and genetic diversity of PCV2 and PEDV within Sichuan Province remain limited.MethodsThis study examines clinical samples from 352 diarrheal piglets across 63 pig farms in 17 regions of Sichuan Province, revealing positivity rates of 42.33% (149/352) for PCV2 and 50.28% (177/352) for PEDV, with a co-infection rate of 27.56% (97/352). Notably, the highest positivity rates were observed in Ziyang for PCV2 at 61.90% (13/21), and in Meishan for PEDV at 73.81% (31/42), both regions also reported the highest co-infection rates of 47.62%.Results and discussionSeasonal analysis indicated that PEDV infections peaked during winter, whereas PCV2 showed no significant seasonal trends. Phylogenetic analysis identified 14 PCV2 strains, categorizing 2 as PCV2b (14.29%), 10 as PCV2d (71.43%), and 2 as PCV2e (14.29%). Among the 16 PEDV strains, 2 were classified as G1a (12.5%) and 14 as G2a (87.5%), with PCV2d and PEDV G2a identified as the predominant strains in the region. The study also highlights a high mutation rate at the antigenic sites of both viruses, potentially affecting vaccine efficacy. These findings underscore the need for ongoing surveillance and vaccine development tailored to the prevalent strains to improve control measures within the province.
THE REPORT ON THE KAZAKHSTAN DELEGATION PARTICIPATION IN THAILAND TRAINING COURSE FOR CONCERNED OFFICIALS ON DRUG TREATMENT AND REHABILITATION
Authors: M.V. Prilutskaya 
Published: October 2024

The article presents a report on the participation of the Kazakhstan delegation in the training course for concerned officials on Drug Treatment and Rehabilitation in the period of 24-31 August, 2015 (Thailand). The role of Conference on Interaction and Confidence Building Measures in Asia was introduced in part of activity aimed to drug abuse combating as well as treatment and rehabilitation. The goals and objectives of the training course were emphasized. The article notices the work principles for 24 member states. The results of the training course were reflected in the form of the 5 recommendatory principles.
В статье приведен отчет об участии казахстанской делегации в учебном курсе по лечению и реабилитации наркозависимых для заинтересованных официальных лиц, прошедший с 24 по 31 августа 2015 года в Таиланде. Подчеркнута роль работы Секретариата Совещания по Взаимодействию и мерам доверия в Азии по внедрению мероприятий, направленных на противодействие наркомании, в том числе в сфере лечения и реабилитации зависимостей. Освещены основные цели и задачи обучающего курса. Упомянуты принципы работы делегаций из 24 стран-участниц. Результаты тренинга отражены в форме 5 рекомендательных принципов.
Мақалада2015 жылдың24-31 тамызы аралығында Тайландта қазақстандық делегацияның нашақорлыққа тәуелділерді емдеу және сауықтыру бойынша мүдделі ресми тұлғаларға арналған оқыту курстарына қатысуы туралы есеп берілген. Азияда нашақорлыққа қарсы әрекеттерге бағытталған, оның ішінде тәуелділіктерді емдеу және сауықтыру аясындағы шараларды енгізу жөніндегі Өзара әрекет ету және сенім шаралары бойынша Кеңес Хатшылығы жұмысының рөлі аталып өтті. Оқыту курсының негізгі мақсаттары мен міндеттері жарияланды. 24 қатысушы-ел делегацияларының жұмыс принциптері еске салынды. Жаттығу нәтижелері ұсыныс принциптерінің5-ші нысанында көрсетілген.
ЭТИОЛОГИЧЕСКИЕ И КЛИНИЧЕСКИЕ ПРЕДИКТОРЫ ВОЗВРАТНОЙ ИШЕМИИ МИОКАРДА
Authors: Д.А. Мансурова , Л.К. Каражанова 
Published: October 2024

В работе рассматривается проблема возврата симптомов ишемической болезни сердца (ИБС) у пациентов, перенесших реваскуляризацию миокарда (хирургическую и/или эндоваскулярную): распространенность факторов риска, особенности коронарного кровотока, «сосудистые» причины возвратной ишемии миокарда, вопросы приверженности к терапии. Целью нашего исследования было разработать эффективные меры вторичной профилактики для улучшения прогноза ИБС у пациентов после реваскуляризации миокарда. Обозначена важность создания обучающих школ для повышения информированности и приверженности к лечению.
The problem of return of symptoms of coronary heart disease (CHD) in patients undergoing myocardial revascularization (surgical and/or endovascular): prevalence of risk factors, especially in coronary blood flow, «vascular» causes recurrent myocardial ischemia, adherence to therapy considered in this work. The aim of our study was to develop effective measures to improve secondary prevention of CHD prognosis in patients after myocardial revascularization. The importance of the creation of training schools to raise awareness of and adherence to treatment denoted.
Бұл жұмыста миокард реваскуляризациясын (хирургиялық және/немесе эндоваскулярлы) өткерген науқастардағы жүректің ишемиялық ауруы(ЖИА) симптомдарының қайталану мәселесі қаралған: қауіп факторларының таралуы, тәждік қанайналым ерекшеліктері, қайталамамиокард ишемиясының «тамырлық» себептері, терапияға қажеттілік сұрақтары. Біздің зерттеуіміздің мақсаты миокард реваскуляризациясынан кейін науқастарда ЖИА болжамын жақсарту үшін екіншілік алдын алудың тиімді әдісін құрастыру. Емге қажеттілік пен ақпараттандыруды жоғарылату үшін үйрету мектептерін құру маңыздылығы көрсетілген.
ЗАКОНОМЕРНОСТИ ПЕРЕСТРОЙКИ ЛИМФОЦИРКУЛЯТОРНОГО РУСЛА ПОДМЫШЕЧНОЙ ОБЛАСТИ ПРИ РАКЕ МОЛОЧНОЙ ЖЕЛЕЗЫ
Authors: Ш.Х. Ганцев , Ш.Р. Кзыргалин , А.Н. Каюмова 
Published: October 2024

Цель – выявить закономерности макроскопических изменений строения подмышечного лимфатического аппарата при раке молочной железы. Материал и методы.Объектами настоящего исследования послужили комплексы тканей, взятые у 100 лиц женского пола, во время хирургического вмешательства по поводу рака молочной железы и обработанные методом сонолиподеструкции. Результаты. Анализ лимфатических карт позволил разработать комбинированную схему градации функционального состояния лимфатических узлов и выделить (классифицировать) типы реструктурированного подмышечного лимфатического коллектора: «Последовательный», «Магистральный», «Равномерный», «Радиальный», «Сетчатый». Была подсчитана частота выявления того или иного типа подмышечного лимфатического аппарата. Заключение. Предлагаемая классификация является условной, не исключается вариант перехода одного типа подмышечного лимфатического коллектора в другой, то есть, возможно, это этапы одного процесса в различные зафиксированные моменты времени.
The aim is identify patterns of macroscopic changes in the structure of the axillary lymphatic system in breast cancer. Material and methods. The objects of this study were the complex tissue taken from 100 females, during surgery for breast cancer and treated by sonolipodestruction. Results. Analysis of lymph maps allowed to develop a combined functional state graduation scheme of the lymph nodes and highlight the types of axillary lymph collector restructured “Successive”, “Magistral”, “Uniform”, “Radial”, “Reticulated”. It was calculated incidence of a particular type of axillary lymphatic system. Conclusion. The proposed classification is conditional, not be excluded that the transition of one type of axillary lymph collector to another, that is, maybe it's the same process steps in various fixed points in time.
Мақсаты – cүт безі обыры кезіндегі қолтықасты лимфалық құрылғы құрылымының макроскопиялық өзгерістерінің заңнамалылығын анықтау. Материал және әдістері. Сүт безі обырына байланысты хирургиялық араласулар кезінде 100 әйелден алынған және сонолиподеструкция әдісімен өңделген тіндер кешені осы зерттеу нысандары болып қызмет етті. Нәтижелер. Лимфалық карталарды талдау лимфалық түйіндердің функционалдық жағдайы градациясының араласқан сұлбасын әдістеуге және қайта құрылымдалған қолтықастылық лимфалық коллектордың түрлерін бөлуге (жіктеуге) мүмкіндік береді: «Жүйелі», «Магистралды», «Бірқалыпты», «Радиалды», «Торлы». Айқындаудың сол немесе одан басқа қолтықастылық лимфалық құрылғы түрі жиілігі есептелген болатын. Қорытынды. Ұсынылған жіктеме шартты болып табылады, қолтықастылық лимфалық коллектордың бір түрінен бас түріне ауысу нұсқасы алып тасталмайды, яғни ол әртүрлі уақыттың белгіленген сәттеріне бір үрдістің кезеңдері болуы мүмкін.
UVULA EDEMA DUE TO ECBALİUM ELATERİUM
Authors: G. Kavalci , C. Kavalci 
Published: October 2024

Ecballium Elaterium is a plant that grows in the Mediterranean. It is used as a folk remedy in the treatment of sinusitis. In this case report, we aimed to present a patient, who developed uvular edema due to the use of squirting cucumber. A 38-year-old female presented to our emergency department with the complaints of shortness of breath and difficulty swallowing. It should be remembered that the medicines used in traditional treatment methods can have fatal consequences.
Ecbalium elaterium (Бешенный огурец) - растение, произрастающее в Средиземном море. Используется как народное средство при лечении гайморита. В этом отчете мы хотели представить случай обращения пациентки, 38-летней женщины, обратившейся в отделение неотложной помощи с жалобами на одышку и затрудненное глотание. Был диагностирован увулярный отек языка из-за употребления в лечебных целях Ecbalium elaterium (бешенного огурца). Следует помнить, что лекарства, используемые в традиционных методах лечения, могут иметь фатальные последствия.
Ecbalium elaterium (құтырған қияр) - Жерорта теңізінде өсетін өсімдік.Гайморитті емдеуде халықтық ем ретінде қолданылады. Бұл есепте біз жедел жәрдем бөлімшесіне тыныс алу және жұтылу қиындықтары туралы шағымданған 38 жастағы әйелдің емделуін ұсынғымыз келді. Емдік мақсаттаEcbalium elaterium (құтырған қияр) қолдану салдарынан тілдің увулярлық ісінуі диагнозы қойылды. Дәстүрлі емдеуде қолданылатын дәрі-дәрмектер өлімге әкелуі мүмкін екенін есте ұстаған жөн.