bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viscoelastic Behavior of Alkyl Ether Sulfate Systems Containing Nanosized Colloidal Silica
Authors: Adamy Steven T. 
Published: January 2019

AbstractSurfactant systems incorporating wormlike micelles (WLM) are utilized in both industrial and consumer products. While the viscoelastic behavior of such systems provides for many desired end‐use properties, there is often a need to further modify the rheological properties of such systems. These WLM systems behave much like polymer systems. Furthermore, incorporation of nanosized particles results in interaction of nanoparticles with the large WLM structures altering the rheological behavior. While there are a number of studies that have focused on the effect of particles on the rheological behavior in cationic surfactant systems, fewer studies have been done on systems containing anionic surfactants. In this study, relaxation behaviors in systems containing sodium alkyl ether sulfate and sodium carbonate were studied. The anionic surfactant was an alkyl ether sulfate with an average chain length of 12 carbons and one ethoxy group. WLM behavior was achieved through the addition of sodium carbonate. Ludox TMA, a nanosized colloidal silica, was employed at different concentrations in the WLM systems. Temperature was varied between 5 and 45°C. While characterization of relaxation in terms of the Maxwell model adequately described data below the threshold of ωτ ~1, the model failed to adequately describe behavior at higher frequencies. A modified expression with an additional relaxation mode adequately described relaxation throughout the frequency range studied. It was also found that zero‐shear viscosities generally increased with an increase in silica concentration, and relaxation times decreased. Measurements of relaxation due to a compressive stress via ultrasonic attenuation measurements in the surfactant/particle systems are also discussed.
Colour profile analysis of Port wines by various instrumental and visual methods
Authors: Soares‐da‐Silva Francisco AG , Campos Francisco M , Ferreira Manuel L , Ribeiro Natália , Amaral Bento , Simões Tomás , Silva Cristina LM 
Published: January 2019

AbstractBACKGROUNDWine colour is an important quality parameter, being the first sensorial attribute evaluated during wine tasting. The perception of wine colour can be different depending on many factors, including the depth of the sample under observation. The main objectives of the present study were to measure the colour of Port wines using CIE L*, a*, b* parameters at different depths with various instrumental techniques (spectrophotometry and colorimetry), and to compare the obtained results with the sensory (visual) perception of colour samples.RESULTSRepresentative profiles of lightness (L*), hue (H*) and chroma (C*) at different depths were obtained using Port wine samples from various categories and ages. In general, relatively good correlations between the colorimetric and spectrophotometric methods were obtained for the L* and H* parameters. The results of the sensory tests also showed good correlations between the visually assessed hue scores and the colorimetric measurements of the H* parameter, particularly at the lower depths tested (up to 4.0 mm).CONCLUSIONSOverall, the results indicate that the colorimetric method can be used for estimating wine colour parameters, providing useful information about the colour profile of wines at different depths. © 2019 Society of Chemical Industry
Quantity assessment of polyphenols, glycoalkaloids and saponins in Solanum scabrum berries of different genetic sources and maturity by HPLC/UV–visible/MS methods
Authors: Yuan Bo , Byrnes David , Dinssa Fekadu F , Simon James E , Wu Qingli 
Published: January 2019

AbstractBACKGROUNDSolanum scabrum berries in sub‐Saharan Africa are prolific but neglected as an agricultural resource. Recognition and application of such underutilized resources rely on systematic study of the relevant phytochemicals of commercial value.RESULTSThe quantities of a total of 54 phytochemicals in Solanum scabrum berries were assessed using HPLC‐MS methods. Berries from eight different genetic sources were analyzed with two entries monitored across different maturation stages. There was a significant variation among mature berries in the accumulation of phenolic acids, 91.5–794 mg·100 g−1 dry weight (DW); flavonols, 76.3–897 mg·100 g−1 DW; anthocyanins, 178–4650 mg·100 g−1 DW; glycoalkaloids, 1.76–1630 mg·100 g−1 DW; and saponins, 82.2–606 mg·100 g−1 DW. Fruit development from immature to post‐frost harvest featured dynamic changes in phytochemical composition and, despite remarkable differences in the absolute magnitude of content, the trend of change was generally similar in different genetic sources.CONCLUSIONSThe genotype‐dependent difference in toxic glycoalkaloids in mature berries may partially explain the consumption controversy as it reflects glycoalkaloid content. The analytical methods applied in this work should serve for quality control of glycoalkaloids thereby improving the safe utilization of this berry. In addition, the selection and breeding of new genotypes with low and safe levels of glycoalkaloids and saponins in the berry could be of value in sub‐Saharan Africa to increase nutrition and generate new income opportunities for growers. © 2019 Society of Chemical Industry
Acacia, cherry and oak wood chips used for a short aging period of rosé wines: effects on general phenolic parameters, volatile composition and sensory profile
Authors: Santos Filipa , Correia Ana C , Ortega‐Heras Mirian , García‐Lomillo Javier , González‐SanJosé María L , Jordão António M , Ricardo‐da‐Silva Jorge M 
Published: January 2019

AbstractBACKGROUNDThere is a restricted knowledge about the potential impact of the use of different wood chip species on the rosé wine aging process. Thus, the aim of this work was to evaluate the general phenolic parameters, aroma composition and sensory profile of rosé wines during a short maturation (20 aging days) in contact with wood chips from oak, acacia and cherry. In addition, the different wood chips were added to a rosé wine without a previous clarification process (unfined wine) and to a rosé wine submitted to a clarification process (fined wine).RESULTSFor the brief maturation time considered, the use of different wood chips induced a tendency for an increase of phenolic content, in particular for unfined rosé wine aged in contact with acacia chips. For volatile composition, the differentiation was clearer for aldehyde compounds group. Regarding sensorial overall appreciation the panel test preferred the unfined rosé wine aged in contact with acacia wood chips.CONCLUSIONSThe results show that, in general, the use of different wood chip species (acacia, cherry and oak) for a brief maturation time of rosé wines could play an important role in rosé wine characteristics, in particular in their phenolic composition. © 2019 Society of Chemical Industry
Mineralisation of tubular bones is affected differently by low phosphorus supply in growing‐finishing pigs
Authors: Sørensen Kristina U , Shiguetomi‐Medina Juan M , Poulsen Hanne D 
Published: January 2019

AbstractBACKGROUNDPhosphorus (P) supply is essential for bone mineralisation. Reduced P may result in osteopenia, whereas excessive P may result in environmental impacts. The objective was to study the long‐term effect of three dietary P levels on net bone mineralisation in growing‐finishing pigs. Eighteen female pigs were fed low P (LP (4.1)), medium P (MP (6.2)) or high P (HP (8.9 g P kg−1 DM)) from 39.7 until 110 kg. Trabecular, cortical and overall bone mineral density (BMD), ash, calcium (Ca) and P were determined after slaughter.RESULTSThe LP diet generally reduced the BMD, ash, Ca and P in all bones, though all measures were markedly lowered in femur compared with humerus. The trabecular BMD in LP pigs was only different in the distal section compared to the MP‐fed pigs (P < 0.05). In addition, ash, Ca and P were lower in the proximal and distal sections. No significant effect of HP was seen. Conclusively, LP caused lower net bone mineralisation, mainly of femur. The trabecular tissue of the distal bones seems to be most metabolically active.CONCLUSIONSThe MP level was sufficient for net bone mineralisation. Femur is recommended for studying bone fragility whereas humerus seems useful to study increased P retention. © 2019 The Authors. Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Expert sampling of VR simulator metrics for automated assessment of mastoidectomy performance
Authors: Andersen Steven Arild Wuyts , Mikkelsen Peter Trier , Sørensen Mads Sølvsten 
Published: January 2019

ObjectiveOften the assessment of mastoidectomy performance requires time‐consuming manual rating. Virtual reality (VR) simulators offer potentially useful automated assessment and feedback but should be supported by validity evidence. We aimed to investigate simulator metrics for automated assessment based on the expert performance approach, comparison with an established assessment tool, and the consequences of standard setting.MethodsThe performances of 11 experienced otosurgeons and 37 otorhinolaryngology residents. Participants performed three mastoidectomies in the Visible Ear Simulator. Nine residents contributed additional data on repeated practice in the simulator. One hundred and twenty‐nine different performance metrics were collected by the simulator and final‐product files were saved. These final products were analyzed using a modified Welling Scale by two blinded raters.ResultsSeventeen metrics could discriminate between resident and experienced surgeons’ performances. These metrics mainly expressed various aspects of efficiency: Experts demonstrated more goal‐directed behavior and less hesitancy, used less time, and selected large and sharp burrs more often. The combined metrics‐based score (MBS) demonstrated significant discriminative ability between experienced surgeons and residents with a mean difference of 16.4% (95% confidence interval [12.6–20.2], P << 0.001). A pass/fail score of 83.6% was established. The MBS correlated poorly with the final‐product score but excellently with the final‐product score per time.ConclusionThe MBS mainly reflected efficiency components of the mastoidectomy procedure, and although it could have some uses in self‐directed training, it fails to measure and encourage safe routines. Supplemental approaches and feedback are therefore required in VR simulation training of mastoidectomy.Level of Evidence2bLaryngoscope, 129:2170–2177, 2019
Palatal anatomy for sleep apnea surgery
Authors: Olszewska Ewa , Woodson B. Tucker 
Published: January 2019

The goal of this review is to advance the understanding of the muscular and soft tissue palatal anatomy as it relates to palatal surgery for sleep apnea and the phenotypic variations that generate the shape and collapsibility of the retropalatal airway. Anatomically, the soft palate has both a proximal and distal segments separated by the palatal genu. The proximal palatal segment has a variable angle from the hard palate (ie, alpha angle) determined by the position and length of the levator veli palatini muscle. The palatopharyngeus muscle (PP) is a major defining element of the palate and lateral pharyngeal wall and forms the medial wall of the lateral palatal space. It is composed of two divisions: the longitudinal palatopharyngeus fasciculi which acts to elevate the pharynx and depress the soft palate and the transverse palatopharyngeus fascicle (Passavant's ridge) which function is a nasopharyngeal sphincter. The lateral palatal space incorporates the supra‐tonsilar fat, and is bounded by muscles that determine the structure of the palate and associated lateral pharyngeal walls. Understanding of palatal muscles and pharyngeal airway phenotypes provides insight into the steps and mechanisms of pharyngoplasty procedures.Level of EvidenceN/A
Milk Polar Lipids in a High‐Fat Diet Can Prevent Body Weight Gain: Modulated Abundance of Gut Bacteria in Relation with Fecal Loss of Specific Fatty Acids
Authors: Milard Marine , Laugerette Fabienne , Durand Annie , Buisson Charline , Meugnier Emmanuelle , Loizon Emmanuelle , Louche‐Pelissier Corinne , Sauvinet Valérie , Garnier Lorna , Viel Sébastien , Bertrand Karène , Joffre Florent , Cheillan David , Humbert Lydie , Rainteau Dominique , Plaisancié Pascale , Bindels Laure B. , Neyrinck Audrey M. , Delzenne Nathalie M. , Michalski Marie‐Caroline 
Published: January 2019

ScopeEnhanced adiposity and metabolic inflammation are major features of obesity associated with altered gut microbiota and intestinal barrier. How these metabolic outcomes can be impacted by milk polar lipids (MPL), naturally containing 25% of sphingomyelin, is investigated in mice fed a mixed high‐fat (HF) diet .Methods and resultsMale C57Bl/6 mice receive a HF‐diet devoid of MPL (21% fat, mainly palm oil, in chow), or supplemented with 1.1% or 1.6% of MPL (HF‐MPL1; HF‐MPL2) via a total‐lipid extract from butterserum concentrate for 8 weeks. HF‐MPL2 mice gain less weight versus HF (p < 0.01). Diets do not impact plasma markers of inflammation but in the liver, HF‐MPL2 tends to decrease hepatic gene expression of macrophage marker F4/80 versus HF‐MPL1 (p = 0.06). Colonic crypt depth is the maximum in HF‐MPL2 (p < 0.05). In cecal microbiota, HF‐MPL1 increases Bifidobacterium animalis versus HF (p < 0.05). HF‐MPL2 decreases Lactobacillus reuteri (p < 0.05), which correlates negatively with the fecal loss of milk sphingomyelin‐specific fatty acids (p < 0.05).ConclusionIn mice fed a mixed HF diet, MPL can limit HF‐induced body weight gain and modulate gut physiology and the abundance in microbiota of bacteria of metabolic interest. This supports further exploration of how residual unabsorbed lipids reaching the colon can impact HF‐induced metabolic disorders.
An algorithmic approach to single‐probe Cherenkov removal in pulsed x‐ray beams
Authors: Archer James , Madden Levi , Li Enbang , Wilkinson Dean , Rosenfeld Anatoly B. 
Published: January 2019

PurposeThe removal of Cherenkov light in an optical dosimetry system is an important process to ensure accurate dosimetry without compromising spatial resolution. Many solutions have been presented in the literature, each with advantages and disadvantages. We present a methodology to remove Cherenkov light from a scintillator fiber optic dosimeter in a pulsed megavoltage x‐ray beam using the temporal waveform across the pulse.MethodsA sample waveform of Cherenkov light can be measured by exposing only the fiber to the beam. By assuming that the Cherenkov waveform closely matches the intensity of incident radiation, this waveform can be convoluted with the instantaneous scintillation response function to generate an expected scintillation signal. By finding the least‐squares fit between these two functions and the experimental data, the estimated Cherenkov contribution can be subtracted off the net signal. This can be applied for arbitrarily complex Cherenkov waveforms (within the 2 ns timing resolution of the data acquisition), and in fact, the results suggest more fluctuations in the waveforms provide a better fit to data.ResultsFour beam profiles for different field sizes and energies were found with this method. They closely matched references data measured with ionization chamber with average differences across the beam no more than 4%. Noisy waveforms are assumed to be the primary cause of differences between the analyzed scintillator and IC results. We propose methods for improving the results and optimizing the data acquisition and analysis processes.ConclusionsThese results demonstrate that it is possible and effective with a single probe to use function fitting of expected data to experimental to remove a complicated Cherenkov signal from the net light signal in pulsed‐beam optical dosimetry.
Extreme restriction design as a method for reducing confounding by indication in pharmacoepidemiologic research
Authors: Secrest Matthew H. , Platt Robert W. , Dormuth Colin R. , Chateau Dan , Targownik Laura , Nie Rui , Doyle Carla M. , Dell'Aniello Sophie , Filion Kristian B. 
Published: January 2019

AbstractPurposeConfounding by indication is a concern in observational pharmacoepidemiologic studies, including those that use active comparator, new user (ACNU) designs. Here, we present a method of restriction to an indication, which we call “extreme restriction,” to reduce confounding in such studies.MethodsAs a case study, we evaluated the effect of proton pump inhibitors (PPIs) on hospitalization for community‐acquired pneumonia (HCAP). PPI use has been associated with increased HCAP risk, but this association likely results from confounding by indication due to gastroesophageal reflux disease (GERD). Using the UK's Clinical Practice Research Datalink, we compared the risk of HCAP within 180 days between PPI users and histamine‐2 receptor antagonist (H2RA) users in an ACNU cohort using Cox proportional hazard models with a time‐fixed exposure definition adjusted for high‐dimensional propensity score deciles. We then performed the same analysis on an “extremely‐restricted” cohort of incident nonsteroidal anti‐inflammatory drug (NSAID) users, some of whom received PPIs for prophylaxis. Because PPIs were given as prophylaxis in this population, confounding due to GERD should be limited. We compared effect estimates between ACNU and restricted cohorts to evaluate confounding in both analyses.ResultsIn the ACNU cohort, PPIs were associated with an increased risk of HCAP (hazard ratio [HR]: 1.25; 95% confidence interval [CI]: 1.05, 1.47), but this association was not present in the restricted cohort (HR: 1.06; 95% CI: 0.75, 1.49).ConclusionsRestriction to a single indication for treatment may reduce confounding by indication in studies conducted in distributed data networks and other large databases.
Ecotypic and genotypic effects on regrowth and heading date in switchgrass (Panicum virgatum)
Authors: Jiang Qingzhen , Webb Stephen L. , Bhandari Hem S. , Bouton Joe H. , Saha Malay C. 
Published: January 2019

AbstractSwitchgrass (Panicum virgatum L.) is a native perennial grass species with great potential for bioenergy and forage. However, knowledge about its genetics and biology related to breeding is still in its infancy. Studying the diversity of switchgrass germplasm will shed light on variability, response to environmental conditions, adaptability, breeding, etc. Thirty‐six switchgrass accessions/cultivars were used to study the ecotypic and genotypic effects on regrowth, heading date, and vegetative growth period. The R‐360 honeycomb design was used for planting these accessions in 2007. Data on regrowth and heading dates were recorded in 2008, 2010, and 2011. Vegetative growth period was calculated by subtracting the regrowth date from the heading date. It was found that the lowland started regrowing earlier (77 ± 0.4 days of the year, DOY) than the upland ecotype (82 ± 0.3 DOY). The upland had earlier heading date (160 ± 0.4 DOY) than the lowland ecotype (173 ± 0.5 DOY). Vegetative growth period was about 18 days longer in the lowland (89 ± 0.6 days) than the upland ecotype (71 ± 0.4 days). For switchgrass (i.e., all accessions), biomass yield was related positively to growth period and heading date; however, biomass was only weakly related to regrowth. Therefore, when targeting biomass in the breeding program, growth period may be a quick and reliable reference in both ecotypes to quickly estimate biomass potential while regrowth and heading date may be better used as a parameter for accessions within an ecotype.
Large‐Scale Analysis of Redox‐Sensitive Conditionally Disordered Protein Regions Reveals Their Widespread Nature and Key Roles in High‐Level Eukaryotic Processes
Authors: Erdős Gábor , Mészáros Bálint , Reichmann Dana , Dosztányi Zsuzsanna 
Published: January 2019

AbstractRecently developed quantitative redox proteomic studies enable the direct identification of redox‐sensing cysteine residues that regulate the functional behavior of target proteins in response to changing levels of reactive oxygen species. At the molecular level, redox regulation can directly modify the active sites of enzymes, although a growing number of examples indicate the importance of an additional underlying mechanism that involves conditionally disordered proteins. These proteins alter their functional behavior by undergoing a disorder‐to‐order transition in response to changing redox conditions. However, the extent to which this mechanism is used in various proteomes is currently unknown. Here, a recently developed sequence‐based prediction tool incorporated into the IUPred2A web server is used to estimate redox‐sensitive conditionally disordered regions at a large scale. It is shown that redox‐sensitive conditional disorder is fairly widespread in various proteomes and that its presence strongly correlates with the expansion of specific domains in multicellular organisms that largely rely on extra stability provided by disulfide bonds or zinc ion binding. The analyses of yeast redox proteomes and human disease data further underlie the significance of this phenomenon in the regulation of a wide range of biological processes, as well as its biomedical importance.
Scalable synthesis of an architectural library of well‐defined poly(acrylic acid) derivatives: Role of structure on dispersant performance
Authors: Lunn David J. , Seo Sungbaek , Lee Sang‐Ho , Zerdan Raghida Bou , Mattson Kaila M. , Treat Nicolas J. , McGrath Alaina J. , Gutekunst Will R. , Lawrence Jimmy , Abdilla Allison , Anastasaki Athina , Knight Abigail S. , Schmidt Bernhard V. K. J. , Bates Morgan W. , Clark Paul G. , DeRocher Jonathan P. , Van Dyk Antony K. , Hawker Craig J. 
Published: January 2019

ABSTRACTThe synthesis and systematic comparison of a comprehensive library of well‐defined polymer architectures based on poly(acrylic acid) is reported. Through the development of new synthetic methodologies, linear, single branched, precision‐branched comb, and star polymers were prepared and their performance as dispersants was evaluated. The ability to accurately control chain lengths and branch points allows the subtle interplay between structure and dispersant performance to be defined and affords critical insights into the design of improved polymeric additives for coating formulations. The general industrial relevance of ionic polymers and branched macromolecular architectures supports these design rules for a wide range of other applications and materials, including as additives for personal care products and in water treatment. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 716–725