bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bayesian model of disease progression in GNE myopathy
Authors: Quintana M. , Shrader J. , Slota C. , Joe G. , McKew J.C. , Fitzgerald M. , Gahl W.A. , Berry S. , Carrillo N. 
Published: December 2018

One Sentence Summary: A Bayesian repeated measures model based on quantitative muscle strength data from a prospective Natural History Study was developed to determine disease progression and design clinical trials for GNE myopathy, a rare and slowly progressive muscle disease.GNE myopathy is a rare muscle disease characterized by slowly progressive weakness and atrophy of skeletal muscles. To address the significant challenges of defining the natural history and designing clinical trials for GNE myopathy, we developed a Bayesian latent variable repeated measures model to determine disease progression. The model is based on longitudinal quantitative muscle strength data collected as part of a prospective Natural History Study. The GNE Myopathy Progression Model provides an understanding of disease progression that would have otherwise required a natural history of unfeasible duration. “Disease age,” the model‐generated measure of disease progression, highly correlates with a variety of clinical, functional and patient‐reported outcomes. With the incorporation of a treatment effect parameter to the GNE Disease Progression Model, we describe a novel GNE Myopathy Disease Modification Analysis that significantly increases power and reduces the number of subjects required to test the effectiveness of novel therapies when compared to more traditional analysis methods. The GNE Myopathy Disease Progression Model and Disease Modification Analysis can be applied to muscle diseases with prospectively collected muscle strength data, and a variety of rare and slowly progressive diseases.
Isocyanide‐Based Multi‐Component Reactions: One‐Pot Catalyst‐Free Synthesis of Carboxamides
Authors: Mokhtari Tayebeh Sattaei , Amrollahi Mohammad Ali , Sheikhhosseini Enayatollah , Sheibani Hasan 
Published: December 2018

AbstractIn this paper, a catalyst‐free procedure is described for the synthesis of novel carboxamide derivatives through a one pot five‐component reaction of cycloalkylidene‐substituted Meldrum's acid, alkyl isocyanide, and 4,4′‐methylene‐ or 4,4′‐oxydianiline. Any by‐product was not prepared through this reaction, and products were separated by a simple work‐up procedure. The other noticeable benefits of this procedure are good yields, mild reaction conditions and use of available materials.
Cellular Detection of Hydrazine as Isoniazid Metabolite by a New Turn‐On Fluorescent Probe: Synthesis, Live Cell Imaging and In Vitro Toxicity Studies
Authors: Banerji Biswadip , K Chandrasekhar , Chatterjee Satadru , Killi Sunil Kumar , Prodhan Chandraday , Chaudhuri Keya 
Published: December 2018

AbstractA new turn‐on fluorescent probe 2‐((pyren‐3‐yl) methyl) isoindoline‐1,3‐dione was synthesized in a single step, high yielding reaction to detect hydrazine in solution. This ligand is highly sensitive to detect hydrazine in micromolar (1.1 μM) concentration in solution. It has high selectivity towards hydrazine compared to other analytes. Different biophysical experiments like hydrazine screening from both tap water and distilled water, vapour phase detection, anti‐interference studies with different analytes also corroborate the phenomenon of selective detection of hydrazine by our ligand. NMR titration and mass spectrum established the mechanism of hydrazine sensing. In addition, the probe was successfully used to trap exogenously added hydrazine inside the cell, which was further utilized to study insitu hydrazine released from an anti‐tubercular drug Isoniazid (INH), after its metabolism.
Facile Surface Modification of Glass‐Fiber Membrane with Silylating Reagent through Chemical Bonding for the Selective Separation and Recycling of Diverse Dyes from Aqueous Solutions
Authors: Li Jia‐Le , Gao Yu‐Hang , Jin Chun‐Xin , Wang Yu , He Miao , Dong Wei‐Wei , Zhao Jinhua , Li Donghao , Shang Hai‐Bo 
Published: December 2018

Abstract3‐(Trimethoxysilyl)‐1‐propanamine (APTMS) modified glass fiber membrane (APTMS‐GF) was prepared via chemical bonding with different volume ratios (APTMS : methanol=1:20, 1:10, 1:5), which was called APTMS‐GF‐1, −2 and −3, respectively. For congo red (CR) with the concentrations ranging from 5 to 45 mg L−1, the removal efficiencies were up to above 95% by filtration with APTMS‐GF composite membranes, but there was no distinct difference in removal capacity with increasing the volume ratio of APTMS. More importantly, on account of the electrostatic interaction, APTMS‐GF composite membrane could selectively separate and recycle neutral bromophenol blue (BPB), cationic methylene blue (MB) and anionic methyl orange (MO) from binary systems including BPB/CR, MB/CR, and MO/CR, respectively. Under the static adsorption, the adsorption process of CR on the APTMS‐GF composite membrane was better fitting with the pseudo‐second‐order kinetic model (R2=0.992) due to the electrostatic interaction, which was confirmed by the effects of inorganic ions and pH in solution. The structural advantage of glass fiber membrane with micropores made all of filtration fulfilled under atmospheric pressure in comparison to the reported membranes. As a result, this work provides a feasible method for fabricating the economic membrane in removing dyes.
A Facile Chemical Precipitation Method for the Synthesis of Nd(OH)3 and La(OH)3 Nanopowders and their Supercapacitor Performances
Authors: Arunachalam Subasri , Kirubasankar Balakrishnan , Rajagounder Nagarajan Erumaipatty , Vellasamy Devadoss , Angaiah Subramania 
Published: December 2018

AbstractA facile chemical precipitation method is used to prepare both lanthanum hydroxide [La(OH)3] and neodymium hydroxide [Nd(OH)3] nanopowders in an ambient temperature without the addition of any surfactants. Both rare‐earth hydroxides nanopowders are characterized by X‐ray diffraction and FE‐SEM analysis. The supercapacitor performances of La(OH)3 and Nd(OH)3 electrodes are studied by cyclic voltammetry, electrochemical AC‐impedance and galvanostatic charge‐discharge studies. It revealed that Nd(OH)3 electrode possesses a high specific capacitance (Csp) than La(OH)3 electrode. Hence, an asymmetric supercapacitor device is fabricated and denoted as Nd(OH)3||AC in 6 M KOH as the electrolyte soaked in the electrospun poly(vinylidene fluoride) membrane as the separator, which exhibited an energy density of 18.8 Wh kg−1 at a power density of 796 W kg−1.
Endothelial Differentiation G Protein-Coupled Receptor 5 Plays an Important Role in Induction and Maintenance of Pluripotency
Authors: Neganova Irina , Cotts Lewis , Banks Peter , Gassner Katja , Shukurov Anvar , Armstrong Lyle , Ladds Graham , Lako Majlinda 
Published: December 2018

Abstract
Direct reprogramming of human somatic cells toward induced pluripotent stem cells holds great promise for regenerative medicine and basic biology. We used a high-throughput small interfering RNA screening assay in the initiation phase of reprogramming for 784 genes belonging to kinase and phosphatase families and identified 68 repressors and 22 effectors. Six new candidates belonging to the family of the G protein-coupled receptors (GPCRs) were identified, suggesting an important role for this key signaling pathway during somatic cell-induced reprogramming. Downregulation of one of the key GPCR effectors, endothelial differentiation GPCR5 (EDG5), impacted the maintenance of pluripotency, actin cytoskeleton organization, colony integrity, and focal adhesions in human embryonic stem cells, which were associated with the alteration in the RhoA-ROCK-Cofilin-PAXILLIN-actin signaling pathway. Similarly, downregulation of EDG5 during the initiation stage of somatic cell-induced reprogramming resulted in alteration of cytoskeleton, loss of human-induced pluripotent stem cell colony integrity, and a significant reduction in partially and fully reprogrammed cells as well as the number of alkaline phosphatase positive colonies at the end of the reprogramming process. Together, these data point to an important role of EDG5 in the maintenance and acquisition of pluripotency. Stem Cells 2019;37:318–331
Recent Advances in Mechanically Robust and Stretchable Bulk Heterojunction Polymer Solar Cells
Authors: St. Onge P. Blake J. , Ocheje Michael U. , Selivanova Mariia , Rondeau‐Gagné Simon 
Published: December 2018

AbstractOrganic bulk heterojunction solar cells are promising candidates as future photovoltaic technologies for large‐scale and low‐cost energy production. It is, therefore, not surprising that research on the design and preparation of these types of organic photovoltaics has attracted a lot of attention since the last two decades, leading to constantly growing values of energy conversion and efficiency. Combined with the possibility of a large‐scale production via roll‐to‐roll printing techniques, bulk heterojunction solar cells enable the fabrication of conformable, light‐weight and flexible light‐harvesting devices for point‐of‐use applications. This perspective review will highlight the recent advances toward mechanically robust and intrinsically stretchable bulk heterojunction solar cells. Mechanically robust fullerene‐based and all‐polymer devices will be presented, as well as a comprehensive overview of the recent challenges and characterization techniques recently developed to overcome some of the challenges of this research area, which is still in its infancy.
Estimated mink home ranges using various home‐range estimators
Authors: Halbrook Richard S. , Petach Marty 
Published: December 2018

ABSTRACTAlthough the American mink (Neovison vison) is a fairly common and valued semiaquatic furbearing species, studies evaluating space use by mink in North America are scarce. We implanted radiotransmitters in 8 male and 6 female mink living within 3 km of the Hudson River between Hudson Falls and Northumberland Dam, New York, USA, during 2009–2011 and estimated Minimum Convex Polygon (MCP), Minimum Bounding Circle (MBC), and Kernel Density Estimate (KDE) home ranges. We also estimated an Ecological Home Range (EHR) using habitat characteristics known to be important to mink. The MBC, MCP, and 95% KDE estimation methods produced home ranges that appear to include area not actually used by mink, while the EHR method appeared to more accurately reflect space used at a finer scale. The mean 95% KDE home‐range estimate was 2.3 times greater than the mean MCP estimated home range and 3.3 times greater than the mean EHR estimate. The size of individual mink EHRs ranged from 23 to 164 ha and did not differ between male and female. Our results indicate that mink home ranges can be quite variable and demonstrates the importance of selecting an estimation method based on management objectives. Home‐range curves and asymptotes calculated using the Michaelis–Menten equation are provided; Site Fidelity and Time To Statistical Independence calculations reported in the rhr package of the Program R Statistical software are discussed. © 2018 The Wildlife Society.
Track plates detect the endangered New Mexico jumping mouse
Authors: Harrow Rachel L. , Horncastle Valerie J. , Chambers Carol L. 
Published: December 2018

ABSTRACTThe New Mexico jumping mouse (Zapus luteus luteus, formerly Z. hudsonius luteus), an endangered subspecies found in the southwestern United States, inhabits riparian areas with tall, dense herbaceous vegetation as habitat. To detect presence of this species for use in defining life history and habitat use, we developed and tested 4 noninvasive track‐plate methods, and selected the best for field use. New Mexico jumping mice have unique feet and toes that are readily distinguishable from other small mammals within their geographic range. We created reference photos of rodent tracks that confirmed the unique footprints of the jumping mouse and tested this method against detection with live traps in the Apache–Sitgreaves, Arizona, and Santa Fe, New Mexico, USA, National Forests, 2016 and 2017. When comparing the 2 detection methods, in only 1 of 16 comparisons did results differ, where we captured jumping mice in live traps, but did not detect them with track plates. Based on our success with this approach, we developed a 14‐minute instructional video (https://www.youtube.com/watch?v=i2x0Ydc1XVM) on assembly, deployment, and interpretation of track plates. Although trapping provided specific information about individuals, the noninvasive nature of our track‐plate design minimized risk of injury or mortality to animals and lowered study costs. © 2018 The Wildlife Society.
On the move towards customer-centric business models in the automotive industry - a conceptual reference framework of shared automotive service systems
Authors: Grieger Marcus , Ludwig André 
Published: December 2018

AbstractDigitalization drives automotive original equipment manufacturers (OEMs) to change their value propositions and open-up towards greater collaboration and customer integration. The shift towards services implies a transformational change from product- towards customer-centricity. This study proposes a conceptual reference framework (CRF) out of a business model perspective to systematize automotive service systems. The CRF presents relevant dimensions and dependencies between the involved stakeholders and the necessary infrastructures in order to facilitate digital service conceptualization in the early phases of the service design. The artifact is developed based on a literature review and conceptual modeling, then iteratively evaluated by means of guideline-supported interviews from three different perspectives and applied to a real problem statement within a case workshop. The results suggest value creation for automotive services occurs in shared mobility networks among interdependent stakeholders in which customers play an integral role during the service life-cycle. Additionally, the results deepen the understanding of service business model development under consideration of industry-specific aspects and suggest the framework to be a beneficial structuring tool that can save resources and specify solution finding.
RNF126 Quenches RNF168 Function in the DNA Damage Response
Authors: Zhang Lianzhong , Wang Zhenzhen , Shi Ruifeng , Zhu Xuefei , Zhou Jiahui , Peng Bin , Xu Xingzhi 
Published: December 2018

Abstract
DNA damage response (DDR) is essential for maintaining genome stability and protecting cells from tumorigenesis. Ubiquitin and ubiquitin-like modifications play an important role in DDR, from signaling DNA damage to mediating DNA repair. In this report, we found that the E3 ligase ring finger protein 126 (RNF126) was recruited to UV laser micro-irradiation-induced stripes in a RNF8-dependent manner. RNF126 directly interacted with and ubiquitinated another E3 ligase, RNF168. Overexpression of wild type RNF126, but not catalytically-inactive mutant RNF126 (CC229/232AA), diminished ubiquitination of H2A histone family member X (H2AX), and subsequent bleomycin-induced focus formation of total ubiquitin FK2, TP53-binding protein 1 (53BP1), and receptor-associated protein 80 (RAP80). Interestingly, both RNF126 overexpression and RNF126 downregulation compromised homologous recombination (HR)-mediated repair of DNA double-strand breaks (DSBs). Taken together, our findings demonstrate that RNF126 negatively regulates RNF168 function in DDR and its appropriate cellular expression levels are essential for HR-mediated DSB repair.
Navigating Our Way Between Market and State
Authors: Smith Jeffery 
Published: December 2018

ABSTRACT:In this address I argue that different perspectives on the normative foundations of corporate responsibility reflect underlying disagreements about the ideal arrangement of tasks between market and state. I initially recommend that scholars look back to the “division of moral labor” inspired by John Rawls’ seminal work on distributive justice in order to rethink why, and to what extent, corporations take on responsibilities normally within the purview of government. I then examine how this notion is related to recent theoretical work in the field of business ethics. I thereafter turn to provide a brief outline of an alternative view that sees corporations as having responsibilities in so far as markets are sites of delegated oversight over the production of social goods that might otherwise be administered by the state.
A consequence of the growth of rotation sets for families of diffeomorphisms of the torus
Authors: ADDAS-ZANATA SALVADOR 
Published: December 2018

In this paper we consider $C^{\infty }$-generic families of area-preserving diffeomorphisms of the torus homotopic to the identity and their rotation sets. Let $f_{t}:\text{T}^{2}\rightarrow \text{T}^{2}$ be such a family, $\widetilde{f}_{t}:\mathbb{R}^{2}\rightarrow \mathbb{R}^{2}$ be a fixed family of lifts and $\unicode[STIX]{x1D70C}(\widetilde{f}_{t})$ be their rotation sets, which we assume to have interior for $t$ in a certain open interval $I$. We also assume that some rational point $(p/q,l/q)\in \unicode[STIX]{x2202}\unicode[STIX]{x1D70C}(\widetilde{f}_{\overline{t}})$ for a certain parameter $\overline{t}\in I$, and we want to understand the consequences of the following hypothesis: for all $t>\overline{t}$, $t\in I$, $(p/q,l/q)\in \text{int}(\unicode[STIX]{x1D70C}(\widetilde{f}_{t}))$. Under these very natural assumptions, we prove that there exists a $f_{\overline{t}}^{q}$-fixed hyperbolic saddle $P_{\overline{t}}$ such that its rotation vector is $(p/q,l/q)$. We also prove that there exists a sequence $t_{i}>\overline{t}$, $t_{i}\rightarrow \overline{t}$, such that if $P_{t}$ is the continuation of $P_{\overline{t}}$ with the parameter, then $W^{u}(\widetilde{P}_{t_{i}})$ (the unstable manifold) has quadratic tangencies with $W^{s}(\widetilde{P}_{t_{i}})+(c,d)$ (the stable manifold translated by $(c,d)$), where $\widetilde{P}_{t_{i}}$ is any lift of $P_{t_{i}}$ to the plane. In other words, $\widetilde{P}_{t_{i}}$ is a fixed point for $(\widetilde{f}_{t_{i}})^{q}-(p,l)$, and $(c,d)\neq (0,0)$ are certain integer vectors such that $W^{u}(\widetilde{P}_{\overline{t}})$ do not intersect $W^{s}(\widetilde{P}_{\overline{t}})+(c,d)$, and these tangencies become transverse as $t$ increases. We also prove that, for $t>\overline{t}$, $W^{u}(\widetilde{P}_{t})$ has transverse intersections with $W^{s}(\widetilde{P}_{t})+(a,b)$, for all integer vectors $(a,b)$, and thus one may consider that the tangencies above are associated to the birth of the heteroclinic intersections in the plane that do not exist for $t\leq \overline{t}$.
Glacier changes between 1971 and 2016 in the Jankar Chhu Watershed, Lahaul Himalaya, India
Authors: DAS SURESH , SHARMA MILAP CHAND 
Published: December 2018

ABSTRACTGlacier changes in the Jankar Chhu Watershed (JCW) of Chandrabhaga (Chenab) basin, Lahaul Himalaya were worked out based on Corona and Sentinel 2A images between 1971 and 2016. The JCW consists of 153 glaciers (>0.02 km2) with a total area of 185.6 ± 3.8 km2that include 82 glaciers with debris-covered ablation zone, comprising 10.9% of the total glacierized area as in 2016. Change analysis based on Corona (1971), Landsat (2000) and Sentinel 2A (2016) was restricted to 127 glaciers owing to the presence of cloud cover on 26 glaciers in 1971. A subset of glaciers was also mapped using Landsat Thematic Mapper (TM; 1989) image. The total glacier area decreased by 14.7 ± 4.3 km2(0.3 ± 0.1 km2a−¹). The number of glaciers in the JCW increased by four between 1971 and 2016 due to fragmentation. More recently (2000–16), recession rate has increased. Clean-ice area decreased by 21.8 ± 3.8 km2(0.5 ± 0.1 km2a−¹) while debris-covered ice increased by 7.2 ± 0.4 km2(0.2 ± 0.01 km2a−¹). Field observations of select glaciers also support derived recession trend in the JCW. Retreat rates in the JCW have been observed to be much lower than previously reported.
Life span bias explains live–dead discordance in abundance of two common bivalves
Authors: Cronin Kelly E. , Dietl Gregory P. , Kelley Patricia H. , Edie Stewart M. 
Published: December 2018

AbstractLife span bias potentially alters species abundance in death assemblages through the overrepresentation of short-lived organisms compared with their long-lived counterparts. Although previous work found that life span bias did not contribute significantly to live–dead discordance in bivalve assemblages, life span bias better explained discordance in two groups: longer-lived bivalve species and species with known life spans. More studies using local, rather than global, species-wide life spans and mortality rates would help to determine the prevalence of life span bias, especially for long-lived species with known life spans. Here, we conducted a field study at two sites in North Carolina to assess potential life span bias between Mercenaria mercenaria and Chione elevata, two long-lived bivalve species that can be aged directly. We compared the ability of directly measured local life spans with that of regional and global life spans to predict live–dead discordance between these two species. The shorter-lived species (C. elevata) was overrepresented in the death assemblage compared with its live abundance, and local life span data largely predicted the amount of live–dead discordance; local life spans predicted 43% to 88% of discordance. Furthermore, the global maximum life span for M. mercenaria resulted in substantial overpredictions of discordance (1.4 to 1.6 times the observed live–dead discordance). The results of this study suggest that life span bias should be considered as a factor affecting proportional abundances of species in death assemblages and that using life span estimates appropriate to the study locality improves predictions of discordance based on life span compared with using global life span estimates.
Evidence for the diet and habitat of two late Pleistocene mastodons from the Midwest, USA
Authors: Birks Hilary H. , van Geel Bas , Fisher Daniel C. , Grimm Eric C. , Kuijper Wim J. , van Arkel Jan , van Reenen Guido B.A. 
Published: December 2018

AbstractWe analyzed intestinal contents of two late-glacial mastodons preserved in lake sediments in Ohio (Burning Tree mastodon) and Michigan (Heisler mastodon). A multi-proxy suite of macrofossils and microfossils provided unique insights into what these individuals had eaten just before they died and added significantly to knowledge of mastodon diets. We reconstructed the mastodons’ habitats with similar multi-proxy analyses of the embedding lake sediments. Non-pollen palynomorphs, especially spores of coprophilous fungi differentiated intestinal and environmental samples. The Burning Tree mastodon gut sample originates from the small intestine. The Heisler mastodon sample is part of the large intestine to which humans had added clastic material to anchor parts of the carcass under water to cache the meat. Both carcasses had been dismembered, suggesting that the mastodons had been hunted or scavenged, in line with other contemporaneous mastodon finds and the timing of early human incursion into the Midwest. Both mastodons lived in mixed coniferous-deciduous late-glacial forests. They browsed tree leaves and twigs, especiallyPicea. They also ate sedge-swamp plants and drank the lake water. Our multi-proxy estimates for a spring/summer season of death contrast with autumn estimates derived from prior tusk analyses. We document the recovered fossil remains with photographs.