bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food Container with Expiration Date Reminder (OPTIMA) as the Solution to Minimize Leftover Food
Authors: Pertiwi O R , Zhafira N , Ma’arij A M , Sari A D 
Published: July 2019

Abstract
As time goes by, food waste has become one of the global issues that needs to be addressed due to its adverse impact on the economy, environment, and social. Preliminary study shows 77% of respondents leaves the food until it expires. Moreover, a study shows that most of the reason consumers discard the food is to avoid the food which almost and has expired. OPTIMA is a food container with expiration reminder product design which aims to avoid expired food disposal. This innovation can be integrated with mobile phone application so that consumers can control the expiration period of stored food in order to be optimized before the expiration date. The expiration date will be displayed on the LED display and indicator lights using the battery power source. It was designed with PDCA process (Plan, Do, Check, Action). Based on usability test through the prototype, 60% of respondents only had less than or equal to one error to use the product for the first time, 80% of respondents stated that the product can be used easily, 80% of respondents were satisfied with the product. It is expected to be used as one of the medias of actualization and development of technology to find alternative and innovative solutions to the problem of food waste stacking and expected as the innovation for household technology.
EASILY (Easy to Use Kitchen Utilities) Designing Cutting Boards Sets for Elderly and Arthritis Sufferers with Quality Function Deployment
Authors: Zubaidi A M F , Sumitro M K , Husna A S 
Published: July 2019

Abstract
Based on the Indonesian Population Census in 2015, the number of elderly people aged over 60 years in Indonesia reached 2.1 million people. Elderly women do ADL (Activities Daily Living) is higher than the population of elderly men. One ADL that is still often done by the elderly woman is cooking while the process of manually using a cutting board. The purpose of this research is to developed cutting board set named EASILY (Easy-to-Use Kitchen Utilities) which is a set of cutting tools consisting of ergonomic knife and cutting board that comfortable to use and also it does not need much power from operator to do the cutting activities. The steps taken with the method of Quality Function Deployment, to process and interpreting consumer need for product specifications. Usability test is applied with satisfaction attribute performed to determine the level of user satisfaction through interview when subject using EASILY product. The result of this reserach show that EASILY have 4 components there are Cutting Board, Knife Holder, Food Holder, and Trash Tray. The subject feel comfortable while using EASILY after doing the usability testing. Recommendation for further reserach the product development can be done using another product design method, and the usability testing should using more respondent.
Training Performance Measurement with Schema and Mental Rotation Test
Authors: Kaewprasert S , Jiamsanguanwong A 
Published: July 2019

Abstract
Training was a crucial technique for skill development and basic foundation of learning in manufacturing while the traditional way of training selection was to trial-and-error those training methods to see its performance which take cost and time. The purpose of present study was to preliminary investigate the training performance measurement using cognitive schema and mental rotation test in camera assembly tasks with basic training and physical training condition for production staffs. 180 novice participants performed in this study. Results revealed that both cognitive schema and mental rotation test could significantly distinguish training performance between basic and physical training condition in the same direction. The implication of this study was on the measurement that could shorten the time and reduce cost in estimating the performance of each training method which could be used to support decision making. Discussion was provided.
Running and Cycling Induced Fatigue on Wrapper vs. BLR Feature Selection for IBk Classification
Authors: Tang S , Loh W P , Lin C F 
Published: July 2019

Abstract
Running and cycling fatigue causes muscle pains, cramps and accidental injuries. Previous studies had considered the importance of tri-axial accelerometer to detect fatigue motion in stability, balance and postural deviation aspects. While tri-axial accelerometer is important, the capability to predict running and cycling fatigue from the biomechanical attributes were unclear. Therefore, the study aims to (i) compare the featured attributes selected from wrapper approach and Binary Logistic Regression (BLR) on running and cycling datasets and (ii) perform IBk classification accuracy comparison on the feature selection attributes. Public running, experimental running and cycling induced fatigue datasets were employed to test the analysis. The most significant attributes identified in the public running was RMS_ML, followed by Range_ML and the cycle frequency in experimental running and cycling respectively. On 10 folds cross-validation classification test using the IBk algorithm in WEKA, accuracies for experimental running and cycling datasets were 93.1% and 90.5% from wrapper method, 65.6% and 76.2% from BLR respectively. Wrapper method performs better than BLR in data overfitting phenomenon. Findings reveal that the mediolateral variation at body trunk motion plays a major impact to predict fatigue running but fatigue cycling shows cycling frequency as the main attribute in fatigue cycling prediction.
An overview on joining of aluminium and magnesium alloys using friction stir welding (FSW) for automotive lightweight applications
Authors: Kayode Oyindamola , Akinlabi Esther Titilayo 
Published: July 2019

Abstract
Lightweight structures are increasingly in demand in the automotive manufacturing industry for fuel economy, vehicle efficiency and meeting reduction in emissions regulations. Weight reduction in automobiles have been achieved traditionally by reducing the body panel steel-sheet thickness and increasing its strength, but this technique is faced with the challenge of reduced stiffness in the panels. In the bid to incorporate numerous light-weighting ideas in manufacturing, the replacement of steel with light metals has been considered. Aluminium and magnesium are alternative materials that could be used to substitute steel because they are both lighter and possess comparable structural characteristics. Aluminium and magnesium has a density of 2.7 g cm−3 and 1.74 g cm−3 respectively compared to steel density of 7.86 g cm−3. However, there is usually unavailability of aluminium for high-volume production. Hence, the joining of aluminium to magnesium in the right proportion could be suitable as potential materials for new automobile applications to mitigate the challenges faced with the usage of steel and availability of aluminium and help to further reduce the vehicle weight. This study focuses on a review of the basis and joining of aluminium and magnesium alloys through friction stir welding to derive insights on appropriate joining process parameters selection.
Why do females sing?—pair communication and other song functions in eastern bluebirds
Authors: Rose Evangeline M , Coss Derek A , Haines Casey D , Danquah Sheridan A , Studds Colin E , Omland Kevin E 
Published: July 2019

Abstract
Female bird song has been underappreciated and understudied, especially in temperate species. Birdsong was originally thought to be a trait used primarily by male songbirds for mate attraction and male/male contest. However, ornithologists have long known that females sing in many tropical songbirds, often for similar functions to male song. Yet, studies of female song in temperate regions remain scarce. Increasing our understanding of the function of female song in temperate species is a powerful step towards discerning the selective pressures that maintain elaborate female signals. In the last few decades, studies of temperate species have highlighted five major functional categories of female song. Using a modeling framework, based on all known functions of song in other species, we tested the function of female song in eastern bluebirds. The modeling framework allowed us to test the effect of multiple complex behaviors simultaneously to predict female song function. Additionally, modeling mitigated issues of multiple testing across the five different functional categories. We found that female song in eastern bluebirds is primarily used in pair communication. Specifically, females sing to strengthen and maintain long-term pair bonds. Strengthening pair-bonds may be advantageous for eastern bluebirds as pairs that remain together between nesting attempts and between years have higher reproductive success. We demonstrate a clear link between the function of female song in pair communication and the likely selective force of long-term pair bonds acting on eastern bluebird reproductive success. Additionally, our study highlights a major function of female song in a temperate species.
Outbreak of Vancomycin-resistant Enterococcus faecium in Interventional Radiology: Detection Through Whole-genome Sequencing-based Surveillance
Authors: Sundermann Alexander J , Babiker Ahmed , Marsh Jane W , Shutt Kathleen A , Mustapha Mustapha M , Pasculle Anthony W , Ezeonwuka Chinelo , Saul Melissa I , Pacey Marissa P , Van Tyne Daria , Ayres Ashley M , Cooper Vaughn S , Snyder Graham M , Harrison Lee H 
Published: July 2019

Abstract

Background
Vancomycin-resistant enterococci (VRE) are a major cause of hospital-acquired infections. The risk of infection from interventional radiology (IR) procedures is not well documented. Whole-genome sequencing (WGS) surveillance of clinical bacterial isolates among hospitalized patients can identify previously unrecognized outbreaks.

Methods
We analyzed WGS surveillance data from November 2016 to November 2017 for evidence of VRE transmission. A previously unrecognized cluster of 10 genetically related VRE (Enterococcus faecium) infections was discovered. Electronic health record review identified IR procedures as a potential source. An outbreak investigation was conducted.

Results
Of the 10 outbreak patients, 9 had undergone an IR procedure with intravenous (IV) contrast ≤22 days before infection. In a matched case-control study, preceding IR procedure and IR procedure with contrast were associated with VRE infection (matched odds ratio [MOR], 16.72; 95% confidence interval [CI], 2.01 to 138.73; P = .009 and MOR, 39.35; 95% CI, 7.85 to infinity; P &lt; .001, respectively). Investigation of IR practices and review of the manufacturer’s training video revealed sterility breaches in contrast preparation. Our investigation also supported possible transmission from an IR technician. Infection prevention interventions were implemented, and no further IR-associated VRE transmissions have been observed.

Conclusions
A prolonged outbreak of VRE infections related to IR procedures with IV contrast resulted from nonsterile preparation of injectable contrast. The fact that our VRE outbreak was discovered through WGS surveillance and the manufacturer’s training video that demonstrated nonsterile technique raise the possibility that infections following invasive IR procedures may be more common than previously recognized.
Association between urinary biomarkers and disease progression in adults with autosomal dominant polycystic kidney disease
Authors: Segarra-Medrano Alfons , Martin Marisa , Agraz Irene , Vilaprinyó Mercè , Chamoun Betty , Jatem Elias , Molina Maria , Colàs-Campàs Laura , Garcia-Carrasco Alicia , Roche Sarai 
Published: July 2019

AbstractBackgroundHeight-adjusted total kidney volume (htTKV) is considered as the best predictor of kidney function in patients with autosomal dominant polycystic kidney disease (ADPKD), but its limited predictive capacity stresses the need to find new biomarkers of ADPKD progression. The aim of this study was to investigate urinary biomarkers of ADPKD progression.MethodsThis observational study included ADPKD patients, and two comparator groups of ischaemic and non-ischaemic kidney injury: benign nephroangiosclerosis patients and non-ischaemic chronic kidney disease (CKD) patients. Proteinuria, htTKV and urinary levels of molecules are associated with ischaemia and/or tubular injury. The slope of estimated glomerular filtration rate (eGFR) was used as a dependent variable in univariate and multivariate models of kidney function decline.ResultsThe study included 130 patients with ADPKD, 55 with nephroangiosclerosis and 40 with non-ischaemic CKD. All patients had increased urinary concentrations of biomarkers associated with tubular lesions (liver fatty acid-binding protein, kidney injury molecule-1, β2-microglobulin) and molecules overexpressed under ischaemic conditions [hypoxia-inducible factor-1α, vascular endothelial growth factor (VEGF) and monocyte chemoattractant protein-1 (MCP-1)]. These biomarkers correlated positively with htTKV and negatively with the eGFR slope. htTKV was the single best predictor of the eGFR slope variability in univariate analyses. However, a multivariate model including urinary levels of β2-microglobulin, MCP-1 and VEGF improved the capacity to predict the decline of eGFR in ADPKD patients compared with htTKV alone.ConclusionsThe urinary levels of molecules associated with either renal ischaemia (VEGF and MCP-1) or tubular damage (β2-microglobulin) are associated with renal function deterioration in ADPKD patients, and are, therefore, candidates as biomarkers of ADPKD progression.
Antimicrobial resistance three ways: healthcare crisis, major concepts and the relevance of biofilms
Authors: Jorge Paula , Magalhães Andreia Patrícia , Grainha Tânia , Alves Diana , Sousa Ana Margarida , Lopes Susana Patrícia , Pereira Maria Olívia 
Published: July 2019

ABSTRACTWorldwide, infections are resuming their role as highly effective killing diseases, as current treatments are failing to respond to the growing problem of antimicrobial resistance (AMR). The social and economic burden of AMR seems ever rising, with health- and research-related organizations rushing to collaborate on a worldwide scale to find effective solutions. Resistant bacteria are spreading even in first-world nations, being found not only in healthcare-related settings, but also in food and in the environment. In this minireview, the impact of AMR in healthcare systems and the major bacteria behind it are highlighted. Ecological aspects of AMR evolution and the complexity of its molecular mechanisms are explained. Major concepts, such as intrinsic, acquired and adaptive resistance, as well as tolerance and heteroresistance, are also clarified. More importantly, the problematic of biofilms and their role in AMR, namely their main resistance and tolerance mechanisms, are elucidated. Finally, some of the most promising anti-biofilm strategies being investigated are reviewed. Much is still to be done regarding the study of AMR and the discovery of new anti-biofilm strategies. Gladly, considerable research on this topic is generated every day and increasingly concerted actions are being engaged globally to try and tackle this problem.
Daily Context for Abusive and Neglectful Behavior in Family Caregiving for Dementia
Authors: Pickering Carolyn E Z , Yefimova Maria , Maxwell Christopher , Puga Frank , Sullivan Tami 
Published: July 2019

Abstract

Background and Objectives
The purpose of this study was to identify risk and protective factors for abusive and neglectful behavior in the context of daily caregiving.

Research Design and Methods
Family caregivers who co-reside with a care recipient with Alzheimer’s disease and related dementia, recruited from social media, completed 21-days of diaries. Multilevel modeling with days (n = 831) nested within caregivers (N = 50) was used to evaluate relationships between hypothesized risk and protective factors and the odds of an abusive or neglectful behavior on a given day.

Results
Disruptions in the daily routine and stress of the caregiver related to behavioral symptoms of the care recipient are significant risk factors for abusive and neglectful behavior. Participating in a meaningful activity with the care recipient when it occurs twice in a day is a significant protective factor against use of a neglect behavior (OR = 0.19; CI 0.06–0.64; p = .01), but not for abusive behavior. Hypotheses that spending the full day together would increase risk, and that receipt of instrumental support and caregiver participation in self-care would decrease risk, were not supported.

Discussion and Implications
Findings demonstrate that risk of an abusive or neglectful behavior varies from day-to-day in the presence and absence of contextual factors, and that the majority of the variance in the odds an abusive or neglectful behavior occurring is related to day-level factors. Findings demonstrate that diary surveys are critical to identifying ecologically valid modifiable risk and protective factors for abusive and neglectful behaviors that can be targeted in future interventions.
The Materials of Mastication: Material Science of the Humble Tooth
Authors: van Casteren Adam , Crofts Stephanie B 
Published: July 2019

Abstract
Dental functional morphology, as a field, represents a confluence of materials science and biology. Modern methods in materials testing have been influential in driving the understanding of dental tissues and tooth functionality. Here we present a review of dental enamel, the outermost tissue of teeth. Enamel is the hardest biological tissue and exhibits remarkable resilience even when faced with a variety of mechanical threats. In the light of recent work, we progress the argument that the risk of mechanical degradation across multiple scales exhibits a strong and continued selection pressure on structural organization of enamel. The hierarchical nature of enamel structure presents a range of scale-dependent toughening mechanisms and provides a means by which natural selection can drive the specialization of this tissue from nanoscale reorganization to whole tooth morphology. There has been much learnt about the biomechanics of enamel recently, yet our understanding of the taxonomic diversity of this tissue is still lacking and may form an interesting avenue for future research.
Use of Contemporary Protease Inhibitors and Risk of Incident Chronic Kidney Disease in Persons With Human Immunodeficiency Virus: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study
Authors: Ryom Lene , Dilling Lundgren Jens , Reiss Peter , Kirk Ole , Law Matthew , Ross Mike , Morlat Phillip , Andreas Fux Christoph , Fontas Eric , De Wit Stephane , D’Arminio Monforte Antonella , El-Sadr Wafaa , Phillips Andrew , Ingrid Hatleberg Camilla , Sabin Caroline , Mocroft Amanda ,   Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study Group
Published: July 2019

Abstract

Background
It is unclear whether use of contemporary protease inhibitors pose a similar risk of chronic kidney disease (CKD) as use of older protease inhibitors.

Methods
Participants in the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study were followed up until the earliest occurrence of CKD, the last visit plus 6 months, or 1 February 2016. Adjusted Poisson regression was used to assess associations between CKD and the use of ritonavir-boosted atazanavir (ATV/r) or ritonavir-boosted darunavir (DRV/r).

Results
The incidence of CKD (10.0/1000 person-years of follow-up; 95% confidence interval, 9.5–10.4/1000 person-years of follow-up) increased gradually with increasing exposure to ATV/r, but the relation was less clear for DRV/r. After adjustment, only exposure to ATV/r (adjusted incidence rate ratio, 1.4; 95% confidence interval, 1.2–1.6), but not exposure to DRV/r (1.0; .8–1.3), remained significantly associated with CKD.

Conclusion
While DRV/r use was not significantly associated with CKD an increasing incidence with longer ATV/r use was confirmed.
Maternal, newborn, child and adolescent health: challenges for the next decade
Authors: Costello Anthony , Naimy Zainab 
Published: July 2019

Abstract
The Millennium Development Goals era achieved substantial improvements in the health of women and children. Yet progress was uneven and many women and children still suffer from preventable mortality and morbidity. The United Nations Secretary General’s Global Strategy for Women’s, Children’s and Adolescents’ Health (2016–2030) set out an ambitious ‘survive, thrive and transform’ agenda for countries as they accelerate progress towards the health-related Sustainable Development Goals. This review highlights aspects of ‘survive, thrive and transform’ that have had strong traction globally, namely quality of care and humanitarian settings for ‘survive’, early childhood development and adolescent health for ‘thrive’ and community engagement and a sustainable environment for ‘transform’.
Using Papaverine and Its Metabolites, 6-Desmethyl Papaverine and 4′,6-Didesmethyl Papaverine as Biomarkers to Improve the Detection Time of Heroin Use
Authors: Wolf Carl E , Pierce Kaitlin L , Goldfine Brett L , Nanco Carrol R , Poklis Justin L , Korzun William J 
Published: July 2019

Abstract
Opioid usage in the USA has increased over the past decade, with prescriptions increasing from 76 million in 1991 to 207 million in 2013. New regulations have curbed the number of prescriptions, leading to an increase in heroin use. Heroin-related overdoses have quadrupled between 2000 and 2015. The traditional urinary biomarkers for indicating heroin use are a combination of morphine and 6-acetyl morphine (6-AM). Morphine is detectable in urine for several days. 6-AM is detected in urine for 2–8 hours. Papaverine has been proposed as an alternative heroin biomarker. It has been reported to have a 1–2 day detection window. Papaverine metabolites have been reported to have up to a 3-day detection window. Presented is a method for the detection of papaverine and its metabolites, 6-desmethyl papaverine (6-DMP) and 4′, 6-didesmethyl papaverine (4,6-DDMP), in urine using a modified Waters® MCX™ microelution method. An ultra-performance liquid chromatography and tandem mass spectrometry (UPLC–MS-MS), with a Waters’ BEH C18 column, and 20 mM ammonium formate water: 20 mM ammonium formate methanol mobile phase was employed. Calibration curves were linear from 0.1 to 50 ng/mL. No interferences were observed from the analysis of multicomponent therapeutic drug or drugs of abuse control materials; intra- and inter-run precision tests were acceptable. A total of 428 genuine urine specimens where heroin use was suspected were analyzed. These included 101 6-AM and 179 morphine only positive samples as well as 6 morphine-negative samples where papaverine and/or metabolites were detected. The determined concentrations in these samples for papaverine, 6-DMP and 4,6-DDMP ranged from 0.10 to 994, 0.10 to 462 and 0.12 to 218 ng/mL, respectively. The method was rugged and robust for the analysis of papaverine and metabolites, 6-DMP and 4,6-DDMP. The use papaverine and metabolites, 6-DMP and 4,6-DDMP has the potential to increase the detection window of heroin use.