bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ageing in place and the internet of things – how smart home technologies, the built environment and caregiving intersect
Authors: Carnemolla Phillippa 
Published: December 2018

AbstractSmart technologies and the Internet of Things (IoT), have the potential to play a significant role in enabling older people to age in place. Although there has been substantial development of new applications of sensor technology in the home, this has tended to be tele-health focused, and there has been less work done on the role of IoT and ageing in place that more broadly considers caregiving and the built environment. Research in the field of IoT development and evaluation has recognised a number of challenges and limitations associated with past smart technology developments to support Ageing in Place, calling for user centeredness and better integration with broader systems. Compounding this, research into Ageing in Place and home environments has focused on built environments and largely ignored the impact of technology in the lives of older people staying at home. Recognising a gap in acknowledging the potential impact of technology on Ageing in Place theories, the purpose of this paper is to conceptualise a way of framing smart technology within an Ageing in Place model that acknowledges the interaction of smart technology with the built environment and caregiving and to present a framework for visualising the interactions that take place. A review of Environmental Gerontology model development is undertaken and a new model is presented that recognises the role of technology in Ageing in Place. Based on this model, a template is developed and three case studies of older people’s experiences of smart home technology, home modifications and caregiving are mapped out. These are used to demonstrate “proof of concept” of the relationships put forward in the HAST model and the pre-curser for a template to help people map smart technology and its role in supporting caregiving and ageing in place. This paper’s position is that technologies such as IoT further support the role of the built environment and caregiving to produce outcomes that enable older people to remain autonomous, independent, safe and well at home. However, a number of risks were also identified through the case studies, the issues of maintenance, cost and ease of use, and willingness to use are considerations and potential barriers to the benefits of smart technology.
What controls the initial peak of an air-gun source signature?
Authors: Watson Leighton M. , Werpers Jonatan , Dunham Eric M. 
Published: December 2018

Seismic air guns are broadband sources that generate acoustic waves at many frequencies. The low-frequency waves can be used for imaging, whereas the high-frequency waves are attenuated and/or scattered before they can reflect from targets of interest in the subsurface. It is desirable to reduce the amplitude of the high-frequency acoustic waves because they are thought to be disruptive, and potentially damaging, to marine life and are not useful for geophysical purposes. The high-frequency acoustic waves are primarily associated with the initial expansion of the air-gun bubble and associated peak in the acoustic pressure time series, which is commonly referred to as the source signature of the air gun. We have developed a quasi-1D model of a seismic air gun coupled to a spherical bubble that accounts for gas dynamics and spatially variable depressurization inside the firing chamber to investigate controls on the initial peak of the source signature. The model is validated against data collected during field tests in Lake Seneca, New York. Simulations and field data show that the initial peak is primarily dependent on the operating pressure. A lower gun pressure results in a smaller peak amplitude and a slower rise time. The slope, the amplitude of the initial peak divided by the rise time, is used as a proxy for environmental impact and can decrease by as much as 50% when the air-gun pressure is reduced from 2000 to 1000 psi. The low frequencies are controlled by the total discharged mass, which is dependent upon the gun volume and pressure. Decreasing the operating pressure while simultaneously increasing the gun volume will reduce the high frequencies while maintaining the desirable low-frequency signals.
Managing the clinical encounter with patients with borderline personality disorder in a general psychiatry setting: key contributions from transference-focused psychotherapy
Authors: Lee Tennyson , Hersh Richard G. 
Published: December 2018

SUMMARYThis article describes how the core principles and techniques of transference-focused psychotherapy (TFP) can be used in general psychiatry to help in the management of patients with borderline personality disorder (or other moderate to severe personality disorders). It focuses on: knowledge – appreciating how an understanding of object relations assists the clinician in assessment and treatment; attitude – developing a stance to manage the confusing and negative feelings that may arise in both clinician and patient; and skills – describing how use of TFP techniques (technical neutrality, analysing the transference and countertransference, and judicious use of interpretation) helps the clinician to continue thinking in the fraught clinical encounter. The structural (including contemporary object relations) and structured approach in TFP are exemplified in clinical vignettes.LEARNING OBJECTIVESAfter reading this article you will be able to:•Apply an understanding of object relations theory to interactions with patients with Borderline Personality Disorder (BPD)•Describe the use of the treatment contract and technical neutrality•Understand and better manage the countertransference in working with patients with BPDDECLARATION OF INTERESTNone.
Initial Diagnostic Work-Up of Acute Leukemia: ASCO Clinical Practice Guideline Endorsement of the College of American Pathologists and American Society of Hematology Guideline
Authors: de Haas Valérie , Ismaila Nofisat , Advani Anjali , Arber Daniel A. , Dabney Raetasha S. , Patel-Donnelly Dipti , Kitlas Elizabeth , Pieters Rob , Pui Ching-Hon , Sweet Kendra , Zhang Ling 
Published: December 2018

Purpose The College of American Pathologists (CAP) and the American Society of Hematology (ASH) developed an evidence-based guideline on the initial diagnostic work-up of acute leukemia (AL). Because of the relevance of this topic to the ASCO membership, ASCO reviewed the guideline and applied a set of procedures and policies for endorsing clinical practice guidelines that have been developed by other professional organizations. Methods The CAP-ASH guideline on initial diagnostic work-up of AL was reviewed for developmental rigor by methodologists. Then, an ASCO Endorsement Expert Panel updated the literature search and reviewed the content and recommendations. Results The ASCO Expert Panel determined that the recommendations from the guideline, published in 2016, are clear, thorough, and based on the most relevant scientific evidence. ASCO fully endorsed the CAP-ASH guideline on initial diagnostic work-up of AL and included some discussion points according to clinical practice and updated literature. Conclusion Twenty-seven guideline statements were reviewed. Some discussion points were included to better assess CNS involvement in leukemia and to provide novel insights into molecular diagnosis and potential markers for risk stratification and target therapy. These discussions are categorized into four sections: (1) initial diagnosis focusing on basic diagnostics and determination of risk parameters, (2) molecular markers and minimal residual disease detection, (3) context of referral to another institution with expertise in the management of AL, and (4) reporting and record keeping for better outlining and follow-up discussion. Additional information is available at: www.asco.org/hematologic-malignancies-guidelines .
The influence of storage condition on nitrite, nitrate and vitamin C levels in vegetables
Authors: Cintya Henni , Silalahi Jansen , De Lux Putra Effendy , Siburian Rikson 
Published: December 2018

Vegetables are the main sources of nitrate and nitrite in food. The presence of nitrate and nitrite at a high level may cause a negative impact on health, because nitrite and nitrate when reduced to nitrite, may react with alkylamine to form carcinogenic nitrosamine. The influence of temperature and time of storage on nitrite, nitrate, and vitamin C contents in vegetables were investigated in this study. The vegetables were sweet mustard, bokchoy, spinach and lettuce obtained from a local market. Samples were stored at ±25oC and ±5oC. Analysis of nitrite, nitrate, and vitamin C was conducted in fresh samples, after storage for 24 and 48 hours. Nitrite was analyzed by spectrophotometry at 540 nm. Nitrate reduced into nitrite with Zn in acidic conditions and then analyzed as nitrite. Vitamin C was analyzed by titration with 2.6-dichlorophenolindophenol. During storage, nitrite and nitrate increased, while vitamin C decreased. Nitrite and nitrate content in fresh samples were 15.22 and 22.46 mg/kg (sweet mustard), 12.57 and 6.55 mg/kg (bokchoy), 20.26 and 90.60 mg/kg (spinach), 18.77 and 32.68 mg/kg (lettuce), respectively. Vitamin C content in fresh samples was 101.15 mg/100g (mustard), 92.17 mg/100g (bokchoy), 88.95 mg/100g (spinach), 40.03 mg/100g (lettuce). After storage for 48 hours at ±25oC, nitrite and nitrate increased 44.97% and 53.19% (mustard), 46.18% and 62.59% (bokchoy), 43.86% and 16.48% (spinach), and 41.05% and 47.09% (lettuce), respectively. Vitamin C decreased 67.57% (mustard), 24.68% (bokchoy), 81.25% (spinach), and 79.74% (lettuce). Storage at ±5oC, showed that nitrite and nitrate increased 27.54% and 35.08% (mustard), 13.75% and 43.51% (bokchoy), 19.59% and 10.60% (spinach), 19.85% and 25.16% (lettuce), respectively. Vitamin C decreased 30.88% (mustard), 6.05% (bokchoy), 60.92% (spinach), and 74.94% (lettuce). During storage, nitrite and nitrate increased more significantly at ±25oC than ±5oC while vitamin levels C decreased and were more effective at 25oC than 5oC.
Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA): a study protocol to investigate in vivo Plasmodium falciparum malaria parasite growth in the context of pre-existing immunity
Authors: Kapulu Melissa C. , Njuguna Patricia , Hamaluba Mainga M. ,   CHMI-SIKA Study Team
Published: December 2018

Malaria remains a major public health burden despite approval for implementation of a partially effective pre-erythrocytic malaria vaccine. There is an urgent need to accelerate development of a more effective multi-stage vaccine. Adults in malaria endemic areas may have substantial immunity provided by responses to the blood stages of malaria parasites, but field trials conducted on several blood-stage vaccines have not shown high levels of efficacy. We will use controlled human malaria infection (CHMI) studies with malaria-exposed volunteers to identify correlations between immune responses and parasite growth rates in vivo. Immune responses more strongly associated with control of parasite growth should be prioritized to accelerate malaria vaccine development. We aim to recruit up to 200 healthy adult volunteers from areas of differing malaria transmission in Kenya, and after confirming their health status through clinical examination and routine haematology and biochemistry, we will comprehensively characterize immunity to malaria using >100 blood-stage antigens. We will administer 3,200 aseptic, purified, cryopreserved Plasmodium falciparum sporozoites (PfSPZ Challenge) by direct venous inoculation. Serial quantitative polymerase chain reaction to measure parasite growth rate in vivo will be undertaken. Clinical and laboratory monitoring will be undertaken to ensure volunteer safety. In addition, we will also explore the perceptions and experiences of volunteers and other stakeholders in participating in a malaria volunteer infection study. Serum, plasma, peripheral blood mononuclear cells and extracted DNA will be stored to allow a comprehensive assessment of adaptive and innate host immunity. We will use CHMI in semi-immune adult volunteers to relate parasite growth outcomes with antibody responses and other markers of host immunity. Registration: ClinicalTrials.gov identifier NCT02739763.
Femoral vascular complications following cardiac catheterisation
Authors: Williams Trent , Khan Arshad , Savage Lindsay , Condon Jeremy , Boyle Andrew J , Collins Nicholas , Inder Kerry J 
Published: December 2018

Aim: This study examines the factors associated with femoral vascular complications (FVCs) following cardiac catheterisation. Methods: In a study using a case control design, patients with an FVC (pseudoaneurysm or retroperitoneal bleed) were examined over 5 years. Multivariable logistic regression was used to determine associations with FVCs. Results are reported as adjusted odds ratios (AOR) and 95% confidence intervals (CIs). Results: Seventy-eight (0.65%) patients experienced FVCs (mean age: 65 years, sex: 50% female). Factors that increased the likelihood of experiencing FVC were being female (AOR 2.9, 95% CI 1.3–6.1), smoking (AOR 7.4, 95% CI 3.5–16), having diabetes mellitus (AOR 7.5, 95% CI 3.4–16), having hypertension (AOR 2.9, 95% CI 1.2–6.9), taking anticoagulant medication (AOR 16, 95% CI 5.5–45) having an elevated body mass index (AOR 1.1, 95% CI 1.0–1.2) and the use of vascular closure devices (AOR 3.4, 95% CI 0.61–19). Use of a compression device reduced the likelihood of FVCs developing (AOR 0.6, 95% CI 0.3–1.0). Conclusion: Sex, cardiovascular disease risk factors, and procedural factors remain important in developing FVCs.
Assessing skin damage and prevention in elderly patients
Authors: Todd Marie 
Published: December 2018

From dryness, tears, pressure ulcers to moisture-related damage, elderly skin requires more attention from health professionals. Marie Todd highlights these common skin problems and discusses the assessment skills and preventative measures to improve patient quality of life Maintaining skin integrity in elderly patients is one of the core elements in all fields of nursing. It is important that nurses are able to identify and eliminate as far as possible the risk factors for poor skin health, which include cognitive impairment, comorbidity, and polypharmacy. Good practice involves being aware of skin problems that are likely to affect older people, and implementing robust preventative and management strategies to help reduce the incidence of skin problems. Dry skin, skin tears, moisture-related skin damage, and pressure ulcers are the most common skin problems experienced by older people. This article will highlight these issues and provide some measures practice nurses can implement and prescribe to help prevent and manage these skin problems.
The Care Quality Commission's state of care report
Authors: Frankova Helena 
Published: December 2018

The Care Quality Commission's state of health and adult social care in England report found that general practices maintained good quality care from last year. Understanding what the report found is essential for nurses in order to continue this trend in their practice The Care Quality Commission's state of care 2017/18 report reviews the performance of more than 31 000 healthcare providers, 22% of which are GP services. Despite the range of difficulties experienced by the sector, the regulator found that good quality care has broadly been maintained, and, in some cases, improved. GP services were found to have the highest overall proportion of ‘good’ and ‘outstanding’ services (96%) of the four professional groups reviewed. The report explored various factors that the sustainability of good quality care depends on. These range from access to care, quality management, capacity and commissioning to workforce management, recruitment and retention. The regulator is clear that the performance of individual providers must be supplemented by successful collaboration, enabling providers to work together to provide joined-up care for service users.
Using cognitive behavioural therapy techniques in COPD
Authors: Heslop-Marshall Karen 
Published: December 2018

It is estimated that by 2020 chronic obstructive pulmonary disease is likely to become the fourth leading cause of death. People living with this condition may experience symptoms that can be managed with cognitive behavioural therapy, says Karen Heslop-Marshall Chronic obstructive pulmonary disease (COPD) is a term oftened used to describe two lung conditions in particular: chronic bronchitis and/or emphysema. Patients with COPD often experience symptoms of breathlessness, anxiety, panic and depression, and practice nurses are ideally placed to address these symptoms. This article looks at the use of cognitive behavioural therapy (CBT) techniques in symptom management, describes methods to assess the psychological impact of breathlessness, and outlines common techniques evaluated in a COPD CBT study by Heslop-Marshall et al (2018) . Research found that respiratory nurses were able to learn and deliver CBT techniques to patients with COPD and improved their symptoms of anxiety, depression, quality of life and reduced their use of healthcare resources. Self-management in primary care can be improved with CBT skills and practice nurses could improve self-management by incorporating CBT techniques.
Pemanfaatan Jamur Simbion Sponge dalam Bioisomerasi Asam Lemak pada Dedak untuk Menghasilkan Asam Lemak Cis
Authors: Trianto Agus , Sedjati Sri , Radjasa Ocky Karna , Afriyanto Rachmat , Muchlisin Sakti Imam , Radjasa Septhy Kusuma , Bahry Muhammad Syaifudien 
Published: December 2018

Utilization of Sponges Symbiotic Fungus in the Bioisomeration of Fatty Acids in Brans to Produce Cis Fatty Acid Trans fatty acids are known to have a negative impact on human health such as triggering the coronary heart and blood vessel related diseases. However, many food and animal feed contain trans fatty acids. Bran, which is widely used as animal feed has high fatty acid content and the majority are trans fatty acids. This study aims to determine the potential of Trichoderma harzanum, a sponge symbiont fungus, in the process of fatty acid bioconversion in bran. Bran was fermented in saline and non-salin condition for 15 days in the room temperature. Both fermented and not bran was extracted with methanol, and the extracts were concentrated with rotary evaporator. Fatty acid extracts were analyzed on the GC with hydrolysis and methylation as pre-treatments. The test results showed the fatty acid composition changed, and the was formation of new fatty acids. The bioisomeration process occurs in the Trans-9-Elaidic acid Methyl esther into Cis-9-Oleic Methyl ester. Cis-9-oleic acid is known as oleic acid which is widely found in olive and sunflowers oil. The fungus has potential as biocatalys for production of cis fatty acid. Asam lemak trans dikenal mempunyai dampak negatif terhadap kesehatan manusia seperti memicu terjadinya penyakit jantung koroner dan penyakit terkait pembuluh darah. Namun asam lemak trans banyak terkandung dalam berbagai jenis bahan makanan maupun pakan ternak diantaranya adalah dedak. Dedak banyak digunakan sebagai pakan ternak mempunyai kandungan asam lemak yang tinggi dan mayoritas adalah asam lemak trans. Penelitian ini bertujuan untuk mengetahui potensi jamur simbion spons Trichoderma harzanum dalam proses biokonversi asam lemak pada dedak. Fermentasi dedak dilakukan dalam kondisi salin dan unsalin selama 15 hari pada suhu ruang. Dedak yang difermentasi maupun tidak kemudian diekstrak dengan metanol kemudian dipekatkan dengan rotari eveporator. Ekstrak asam lemak degan GC dengan pre-treatment meliputi hidrolisis dan metilasi. Hasil uji menunjukan adanya perubahan komposisi dan terbentuknya asam lemak baru. Proses bioisomerasi terjadi pada Trans-9-Elaidic acid Methyl estermenjadi Cis-9-Oleic Methyl ester. Cis-9-oleic acid yang dikenal dengan asam oleat yang banyak terdapat dalam minyak zaitun dan bunga matahari. Jamur T. Harzianum mempunyai potensi sebagai biokatalis untuk memproduksi asam lemak cis.
URGENSI KONTRAK KERJA YANG BERKEADILAN SEBAGAI UPAYA PERLINDUNGAN HUKUM RAHASIA DAGANG
Authors: Annisa Rizki Nur , Sulistiyono Adi , Latifah Emmy 
Published: December 2018

Rahasia dagang merupakan ‘jantungnya’ keberlangsungan sebuah bisnis. Oleh karena rahasia dagang mempunyai posisi yang sangat vital, pelaku usaha berusaha melakukan proteksi sangat ketat. Pelanggaran rahasia dagang di Indonesia sebagian besar dilakukan oleh karyawan, dikarenakan lemahnya kesadaran karyawan untuk memenuhi kewajibannya dan akibat lemahnya perlindungan hukum. Dibutuhkan kontrak kerja yang mengikat Karyawan dan Pemilik Rahasia dagang untuk memberi batasan hak dan kewajiban serta sanksi sebagai bentuk perlindungan hukum rahasia dagang. Untuk mencapai tujuan itu digunakan metode penelitian hukum normatif untuk mengkaji urgensi kontrak kerja yang berkeadilan sebagai upaya perlindungan hukum rahasia dagang. Hasil penelitian ini menunjukkan bahwa dengan adanya kontrak kerja yang adil dapat menjadi alternatif upaya perlindungan hukum rahasia dagang; dikarenakan hak dan kewajiban karyawan yang diatur secara mutual menjadikan rahasia dagang dapat dilindungi secara optimal.
TITIK SINGGUNG KERAGAMAN SISTEM HUKUM DALAM PEMBAGIAN HARTA KEKAYAAN PERKAWINAN PADA PERKAWINAN SERIAL
Authors: Yunanto Yunanto 
Published: December 2018

Realitas menunjukkan adanya inkonsistensi dalam memaknai dan melakukan pembagian harta kekayaan perkawinan akibat adanya keragaman aturan khususnya dalam perkawinan serial. Rumusan masalah dalam penelitian ini terkait titik singgung kesamaan makna dan hakikat pembagian harta kekayaan perkawinan dalam keragaman sistem hukum harta perkawinan; dan penyelesaian pembagian harta kekayaan perkawinan dalam perkawinan serial berbasis keragaman aturan dalam praktik di pengadilan. Metode pendekatan yang digunakan dalam penelitian ini adalah metode yuridis empiris. Hasil penelitian menunjukkan: terdapat kesamaan makna dan hakikat pembagian harta kekayaan perkawinan dalam keragaman sistem hukum harta kekayaan perkawinan pada harta yang diperoleh selama perkawinan di luar harta yang diperoleh karena warisan dan hibah; dan dalam perkawinan serial terbentuk masing-masing kelompok harta kekayaan perkawinan yang terpisah dan berdiri sendiri-sendiri.
Twin pregnancy in uteri with congenital anomalies: prenatal diagnosis by three- dimensional ultrasound
Authors: Zohav Efraim , Leytes Sophia , Anteby Eyal Y. , Grin Leonti 
Published: December 2018

Abstract

Objectives
To establish a practical and valid method for the diagnosis of twin gestation in uteri with Müllerian anomalies in the first trimester of pregnancy.

Case presentation
This was a prospective cohort study. Two cases with congenital uterine anomalies were followed prospectively from 7 weeks of gestation and compared to eight controls. The longitudinal to transverse uterine lumen diameter ratio (LTDR) was measured in mid-sagittal and coronal planes. The LTDR was compared between unicornuate and didelphys uteri to normal uteri controls weekly. The area under the curve for the coronal and sagittal planes were 1.000 and 0.823, respectively. For the coronal plane, an LTDR of 1.15 was selected as optimal for predicting uteri with a Müllerian anomaly, with a sensitivity of 100%, specificity of 100%. An LTDR of 1.68 in the sagittal plane was selected as optimal for predicting anomalous uteri, with a sensitivity of 100%, specificity of 73%.

Conclusions
LTDR ratios measured in mid sagittal and coronal planes of unicornuate and didelphys uteri with twin gestation during the first trimester of pregnancy are highly predictive of Müllerian anomalies. Early diagnosis of uterine anomalies could provide a reference to initiate earlier meticulous follow-up.