bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous reversion of a lineage switch following an initial blinatumomab-induced ALL-to-AML switch in MLL-rearranged infant ALL
Authors: Wölfl Matthias , Rasche Mareike , Eyrich Matthias , Schmid Renate , Reinhardt Dirk , Schlegel Paul G. 
Published: June 2018

Key Points
A case of MLL-rearranged leukemia that rapidly adapts to immunological stimuli illustrating the high plasticity of this phenotype.
Synthesis of a gadolinium based-macrocyclic MRI contrast agent for effective cancer diagnosis
Authors: Jeong Yohan , Na Kun 
Published: June 2018

Abstract

Background
Gadolinium-based contrast agents are widely used as a contrast agent for magnetic resonance imaging. Since gadolinium ions are toxic, many chelators are developed to bind gadolinium ions to prevent free gadolinium-associated disease. However, many reports indicated that linear chelator-based contrast agents are associated with nephrogenic systemic fibrosis (NSF) in patients with low kidney function. Therefore, the demand for stable macrocyclic chelator-based contrast agent is now increasing.

Method

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate (DOTA) was conjugated to lactobionic acid (LBA) through DCC-NHS coupling reaction. Gd
3+
(gadolinium ion) was chelated to 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate-lactobionic acid (DOTA-LAE) and free Gd
3+
was removed using a cation exchange column. In vitro cytotoxicity of contrast agent towards normal cells was measured using MTT assay. For in vivo MR imaging, contrast agents were intravenously injected to tumor-bearing mice and imaged by a MR imaging scanner.

Results
This new macrocyclic gadolinium-based contrast agent showed enhanced in vitro paramagnetic properties compared to Gadovist. In addition, Gd-DOTA-LAE showed a 29% increased contrast enhancement of tumor tissue compared to normal tissue within 20 min past IV injection.

Conclusions
We developed a new macrocyclic T1-weighted MR contrast agent. This new contrast agent offers various opportunities for cancer detection and diagnosis.
Assessment of outcome measures for cost–utility analysis in depression: mapping depression scales onto the EQ-5D-5L
Authors: Gamst-Klaussen Thor , Lamu Admassu N. , Chen Gang , Olsen Jan Abel 
Published: June 2018

BackgroundMany clinical studies including mental health interventions do not use a health state utility instrument, which is essential for producing quality-adjusted life years. In the absence of such utility instrument, mapping algorithms can be applied to estimate utilities from a disease-specific instrument.AimsWe aim to develop mapping algorithms from two widely used depression scales; the Depression Anxiety Stress Scales (DASS-21) and the Kessler Psychological Distress Scale (K-10), onto the most widely used health state utility instrument, the EQ-5D-5L, using eight country-specific value sets.MethodA total of 917 respondents with self-reported depression were recruited to describe their health on the DASS-21 and the K-10 as well as the new five-level version of the EQ-5D, referred to as the EQ-5D-5L. Six regression models were used: ordinary least squares regression, generalised linear models, beta binomial regression, fractional logistic regression model, MM-estimation and censored least absolute deviation. Root mean square error, mean absolute error and r2 were used as model performance criteria to select the optimal mapping function for each country-specific value set.ResultsFractional logistic regression model was generally preferred in predicting EQ-5D-5L utilities from both DASS-21 and K-10. The only exception was the Japanese value set, where the beta binomial regression performed best.ConclusionsMapping algorithms can adequately predict EQ-5D-5L utilities from scores on DASS-21 and K-10. This enables disease-specific data from clinical trials to be applied for estimating outcomes in terms of quality-adjusted life years for use in economic evaluations.Declaration of interestNone.
Transcriptional Subtyping and CD8 Immunohistochemistry Identifies Patients With Stage II and III Colorectal Cancer With Poor Prognosis Who Benefit From Adjuvant Chemotherapy
Authors: Allen Wendy L. , Dunne Philip D. , McDade Simon , Scanlon Enya , Loughrey Maurice , Coleman Helen G. , McCann Christopher , McLaughlin Kristy , Nemeth Zsuzsanna , Syed Najeeb Ashraf , Jithesh Puthen Veettil , Arthur Ken , Wilson Richard , Coyle Vicky M. , McArt Darragh , Murray Graeme I. , Samuel Leslie , Nuciforo Paolo , Jimenez Jose , Argiles Guillem , Dienstmann Rodrigo , Tabernero Josef , Picariello Lucia , Messerini Luca , Nobili Stefania , Mini Enrico , Sheahan Kieran , Ryan Elizabeth , Johnston Patrick G. , Van Schaeybroeck Sandra , Lawler Mark , Longley Daniel B. 
Published: June 2018

Purpose Transcriptomic profiling of colorectal cancer (CRC) has led to the identification of four consensus molecular subtypes (CMS1 to 4) that have prognostic value in stage II and III disease. More recently, the Colorectal Cancer Intrinsic Subtypes (CRIS) classification system has helped to define the biology specific to the epithelial component of colorectal tumors; however, the clinical value of these classification systems in the prediction of response to standard-of-care adjuvant chemotherapy remains unknown. Patients and Methods Using samples from four European sites, we assembled a novel cohort of patients with stage II and III CRC (n = 156 samples) and performed transcriptomic profiling and targeted sequencing and generated a tissue microarray to enable integrated multiomics analyses. We also accessed data from two published cohorts of patients with stage II and III CRC: GSE39582 and GSE14333 (n = 479 and n = 185 samples, respectively). Results The epithelial-rich CMS2 subtype of CRC benefitted significantly from treatment with adjuvant chemotherapy in both stage II and III disease ( P = .02 and P < .001, respectively), whereas the CMS3 subtype significantly benefitted in stage III only ( P = .001). After CRIS substratification of CMS2, we observed that only the CRIS-C subtype significantly benefitted from treatment with adjuvant chemotherapy in stage II and III disease ( P = .0081 and P < .001, respectively), whereas the CRIS-D subtype significantly benefitted in stage III only ( P = .0034). We also observed that CRIS-C patients with low levels of CD8+ tumor-infiltrating lymphocytes were most at risk for relapse in both stage II and III disease (log-rank P = .0031; hazard ratio, 12.18 [95% CI, 1.51 to 98.58]). Conclusion Patient stratification using a combination of transcriptional subtyping and CD8 immunohistochemistry analyses is capable of identifying patients with poor prognostic stage II and III disease who benefit from adjuvant standard-of-care chemotherapy. These findings are particularly relevant for patients with stage II disease, where the overall benefit of adjuvant chemotherapy is marginal.
Probing Plasmodium falciparum sexual commitment at the single-cell level
Authors: Brancucci Nicolas M.B. , De Niz Mariana , Straub Timothy J. , Ravel Deepali , Sollelis Lauriane , Birren Bruce W. , Voss Till S. , Neafsey Daniel E. , Marti Matthias 
Published: June 2018

Background: Malaria parasites go through major transitions during their complex life cycle, yet the underlying differentiation pathways remain obscure. Here we apply single cell transcriptomics to unravel the program inducing sexual differentiation in Plasmodium falciparum. Parasites have to make this essential life-cycle decision in preparation for human-to-mosquito transmission. Methods: By combining transcriptional profiling with quantitative imaging and genetics, we defined a transcriptional signature in sexually committed cells. Results: We found this transcriptional signature to be distinct from general changes in parasite metabolism that can be observed in response to commitment-inducing conditions. Conclusions: This proof-of-concept study provides a template to capture transcriptional diversity in parasite populations containing complex mixtures of different life-cycle stages and developmental programs, with important implications for our understanding of parasite biology and the ongoing malaria elimination campaign.
Workflow management in radiation oncology: the impact on a high volume department
Authors: Miriyala Raviteja , Thakur Pragyat , Singh Arun O , Gupta Ankita , Yadav Budhi S , Kumar Narendra , Rattan Rajit , Ghoshal Sushmita 
Published: June 2018

Objective: Integration of treatment planning and delivery is paramount for efficient functioning of radiotherapy departments. Workflow management software is a tool available for effective resource management in radiotherapy. The purpose of this study is to evaluate the impact of workflow-management on work-efficiency and organisational ergonomics in a high volume department. Methods: Before implementing the workflow management software (Aria v 11.0™), paper documentation was the predominant mode of communication between physicians and physicists in our department. Case records of patients treated with conformal radiation in the two-month period before and after implementation of workflow management were retrospectively evaluated. Proportion of cases for which treatment was started on the day of appointment was taken as a surrogate for work-efficiency. Results: Of the 343 cases analysed, 190 were treated before implementation of workflow-management, while 153 were treated after. Workflow management has improved overall efficiency from 67%–79%. Conclusion: Implementation of workflow management resulted in significant improvement in efficiency and organisational ergonomics.
Fractional Perimeters from a Fractal Perspective
Authors: Lombardini Luca 
Published: June 2018

Abstract
The purpose of this paper consists in a better understanding of the fractional nature of the nonlocal perimeters introduced in [L. Caffarelli, J.-M. Roquejoffre and O. Savin, Nonlocal minimal surfaces, Comm. Pure Appl. Math. 63 2010, 9, 1111–1144]. Following [A. Visintin, Generalized coarea formula and fractal sets, Japan J. Indust. Appl. Math. 8 1991, 2, 175–201], we exploit these fractional perimeters to introduce a definition of fractal dimension for the measure theoretic boundary of a set. We calculate the fractal dimension of sets which can be defined in a recursive way, and we give some examples of this kind of sets, explaining how to construct them starting from well-known self-similar fractals. In particular, we show that in the case of the von Koch snowflake

S
⊆

ℝ
2

{S\subseteq\mathbb{R}^{2}}

this fractal dimension coincides with the Minkowski dimension. We also obtain an optimal result for the asymptotics as

s
→

1
-

{s\to 1^{-}}

of the fractional perimeter of a set having locally finite (classical) perimeter.
The Peculiarities of Civil-Legal Regulation of Transplantation in Ukraine and Europe
Authors: Herts Alla 
Published: June 2018

Abstract
In modern realities the issue of the quality and accessibility of health services, the cost of medicines, examinations and treatment in general is being increasingly frequently discussed. The attention is focused on such a narrow surgical field as transplantation, because in Ukraine thousands of patients are waiting in line for organ transplantation and very few operations are performed. The main, most secure and common type of transplantation is the transplantation of organs and tissues from a deceased person, the dead body. Cadaveric transplantation, which is used in most developed countries, is hardly carried out in Ukraine. This is due to the fact that the current regulatory base of Ukraine in the field of transplantation does not fully meet the needs of modern medicine and has many gaps. The aim of donation is a future transplantation (including and in cases of blood transfusion and reproductive cells use). The parts (tissues, organs, their parts, individual cells) extracted (separated) from the body in the process of donation can be used generally in the treatment process in a processed form (blood plasma) or in the original state (fertilized reproductive cells). The detailed analysis of the provisions of the national legal system makes it possible to conclude that, despite the absence of direct regulation of relations concerning organ donation and transplantation as material relations, the legal regulations provide the fundamental provisions, which determine their material nature, and therefore offer opportunities for agreementbased regulation. In our opinion, one of the essential legal means of ensuring the rights of participants in the relations of donation and transplantation can be their agreement-based regulation. The peculiarities of civil-legal regulation of transplantation in Ukraine and Europe are simultaneously analysed; and the grounds of its legitimacy are defined.
Determining the Priorities of the Development of EU Research Universities Based on the Analysis of Rating Indicators of World-Class Universities
Authors: Sitnicki Maksym W. 
Published: June 2018

Abstract
The object of this research is the activity of 25 leading research universities in the world. One of the most problematic issues is the in-depth analysis of the ranking indicators of world-class research universities in order to identify the priorities for the development of research universities in the European Union. The following scientific methods were used in the research: generalizations, analysis, synthesis, graphical method, and also comparison method. The study is based on data on the global university rankings in QS World University Rankings 2018 and empirical data from publicly available sources provided by the research universities. The article also systematizes the scientific views of the leading scientists of Europe and the world on the course of development of research universities and analyses the experience of implementing joint scientific projects in the EU countries. The importance of international cooperation between research universities in the fields of academic mobility and scientific research is underlined due to the fact that the global challenges and prospects that the research universities in the European Union and the world are facing are transient and create a tough competitive environment. Strengthening their leadership potential and developing entrepreneurial thinking has been revealed as a modern trend in the development of research universities. The article characterizes the 25 best world-class research universities, and the factors which have enabled them to uncover their strengths and systematize the key areas of in-depth specialization. The contrasting differences between the analysed research universities are shown, as there are significant disparities in the total number of students, foreign students and staff of research universities, showing fundamentally different approaches to the organization of educational and research processes, even within a single country. This is due to the fact that the ratio of student per staff representative significantly affects the quality of education. The author proposes the key development priorities for research universities in the European Union, which consist in intensified work on: academic reputation; the number of foreign students; reputation of employers; improvement of the ratio of the number of students to the number of staff; improvement of quality and increase in the number of citations of scientific publications by university researchers; increasing the share of the university’s participation in international educational and scientific networks of other countries and continents.
Analysis of Internal Defects Appeared in the Continuous Casting
Authors: Stoian Elena Valentina , Bratu Vasile , Enescu Cristiana Maria , Rusanescu Carmen Otilia 
Published: June 2018

Abstract
The paper presents the study of internal defects resulting from the continuous casting of steels. The 50 samples were taken from a total of 20 continuously cast bits of different steel grades. The investigation of the causes of internal defects, shown on the analyzed samples, started from the assumption that the secondary metallurgy was performed correctly. The following internal defects have been evident: internal cracks (axial cracks, section cracks), central porosity and marginal punctuation impurities.
Compaction Behaviour Modelling of Metal-Ceramic Powder Mixtures. A Review
Authors: Popescu Ileana Nicoleta , Vidu Ruxandra 
Published: June 2018

Abstract
Powder mixtures compaction behavior can be quantitatively expressed by densification equations that describe the relationship between densities - applied pressure during the compaction stages, using correction factors. The modelling of one phase (metal/ceramic) powders or two-phase metal-ceramic powder composites was studied by many researchers, using the most commonly compression equations (Balshin, Heckel, Cooper and Eaton, Kawakita and Lüdde) or relative new ones (Panelli - Ambrózio Filho, Castagnet-Falcão- Leal Neto, Ge Rong-de, Parilák and Dudrová, Gerdemann and Jablonski. Also, for a better understanding of the consolidation process by compressing powder blends and for better prediction of compaction behavior, it's necessary the modeling and simulation of the powder pressing process by computer numerical simulation. In this paper are presented the effect of ceramic particles additions in metallic matrix on the compressibility of composites made by P/M route, taking into account (a) the some of above mentioned powder compression equations and also (b) the compaction behavior modeling through finite element method (FEM) and discrete element modeling (DEM) or combined finite/ discrete element (FE/DE) method.
Intelligent Cyber-Mixmechatronic Micro-System for Monitoring and Controlling the Security and Surveillance Robots
Authors: Angelescu Dorin , Gheorghe Gheorghe Ion 
Published: June 2018

Abstract
As a result of the scientific concerns of the Doctoral School of Mechanical Engineering and Mechatronics at Valahia Târgovişte University in the field of robotics dedicated to security and surveillance, the scientific work "Intelligent Cyber- Mixmechatronic Micro-System for Monitoring and Controlling the Security and Surveillance Robots" is in the testing and experimentation phase, within the doctoral (industrial) thesis "Studies, research and contributions regarding the realization of a smart mecatronic robot for security and surveillance applications". The scientific work results in a highly efficient cybermixmecatronic system, unique in Romania, which will be used to control the mechatronic security and surveillance robot, respectively the propulsion and control of its displacement. The robot is controlled through Artificial Intelligence, using the Internet of Things (IoT), which is why the Intelligent Motion Control system must be optimized both in terms of response speeds and energy. At the same time, due to the varied and possibly unstable conditions of the displacement field, the system must meet stringent criteria of reliability, resilience, weather, stability and redundant solutions for on-site repair of potential failures during missions. The cybermixmecatronic system designed to move the robot must carry it safely at the mission site so that it can then return it back to the Command and Control Center. In the paper will be presented the original solution, applicable with minimum of specific modifications (according to the chassis used), to any type of robot requiring both operator-controlled or autoguid control. Thus, a complex project will be realized combining into a unitary Mechatronics, Integronics, Cyber-Mixmechatronics, Artificial Intelligence and Information Technology.
Concept and Armonic Analysis Used for Processing Data Sampled by Mecatronic Devices in Smart Measurement Processes
Authors: Stanciu Dănuț Iulian , Gheorghe Gheorghe , Cioboata Daniela , Abalaru Aurel 
Published: June 2018

Abstract
Harmonic analysis is a mathematical method that performs the determination (approximation) of continuous functions by the sum of ideal sinusoids. By selecting these sinusoids in a judicious way, in defining the methods of smart measurement of a part, it is possible to separate the geometrical elements of a part into geometric elements of the shape (circularity, eccentricity, etc.) of the geometric elements corresponding to the state surfaces. This article, using the research carried out under the doctoral thesis “COMPLEX STUDIES, RESEARCH AND EXPERIMENTATION OF PRECISION MECHANICAL GEARING TRANSMISSIONS USING HIGH PRECISION HARMONICS METHODS ”, aims to perform an original work and thus to present and analyze the main methods of processing the data gathered in the process measurement of the parts made and used in mechatronic equipment by resorting to harmonic analysis.
How Do Institutions Relate to Entrepreneurship: an Integrative Model
Authors: Zhai Qinghua , Su Jing , Ye Minghai , Xu Yuwen 
Published: June 2018

Abstract
This article brings together existing literature on institutions and entrepreneurship. Despite a recent increase in publications on their relationship, this line of inquiry is still very fragmented due to a lack of consistent theoretical framework to guide the selection of institutions. To provide a “big picture” of this research area, an integrative model is proposed around two central themes: theoretical constructs of institutions that work at different levels and their relationship with different aspects of entrepreneurship. This integrative model presents an overview of existing literature, how previous research fit in the model, the gaps in what we know, and the future directions might be taken by scholars hoping to contribute to this important and growing research area.
Mann iteration process for monotone nonexpansive mappings with a graph
Authors: Alfuraidan Monther Rashed 
Published: June 2018

Abstract
Let

(
X
,

∥
⋅
∥

)

{(X,\lVert\,\cdot\,\rVert)}

be a Banach space. Let C be a nonempty,
bounded, closed and convex subset of X and let

T
:

C
→
C

{T:C\rightarrow C}

be a G-monotone nonexpansive mapping. In this work, it is shown
that the Mann iteration sequence defined by

x

n
+
1

=

t
n

⁢
T
⁢

(

x
n

)

+

(

1
-

t
n

)

⁢

x
n

,

n
=

1
,
2
,
…

,

x_{n+1}=t_{n}T(x_{n})+(1-t_{n})x_{n},\quad n=1,2,\dots,

proves the existence of a fixed point of G-monotone nonexpansive
mappings.
Representations for the image-kernel (p,q)-inverses of block matrices in rings
Authors: Mosić Dijana 
Published: June 2018

Abstract
We present the conditions for a block matrix of a ring to have the
image-kernel

(
p
,
q
)

{(p,q)}

-inverse in the generalized
Banachiewicz–Schur form. We give representations for the
image-kernel inverses of the sum and the product of two block
matrices. Some characterizations of the image-kernel

(
p
,
q
)

{(p,q)}

-inverse in a ring with involution are investigated too.
A Radical RN- BS Nursing Class: Outcomes from an Integrative Yoga Elective
Authors: Clark Carey S. 
Published: June 2018

AbstractWith the knowledge of psychoneuroimmunological responses and the known high stress levels of nursing students, as caring nurse educators, we have become ethically obligated to revise and re-vision our current nursing educational practices. Nurse educators should be motivated to create innovative and radical caring science curricular approaches, so that our nurses of the future are in turn supported in creating caring- healing sustainable bedside practices. This paper details the outcomes from an upper level yoga elective in an RN- BSN program. The course is just one within an innovative holistic-integral nursing curriculum that supports nurses in practicing self-care as a way to support their ability to create caring-healing moments and spaces for patients, implement change in the workplace, and avoid the perils of burn-out related to low stress resilience, which is so common within the nursing profession.