bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognozy naukowych wizjonerów a powszechne poglądy o roli nauki we współczesnym świecie
Authors: Jach Łukasz 
Published: July 2018

In the popular works of charismatic scientists you can find messages which presentscientific code as the only appropriate way of speaking about reality. However,the history of science shows that strongly optimistic opinions about therole of the elements of the scientific system in the process of overcoming all theproblems of humanity are not a new phenomenon. From the psychological pointof view, it is interesting to identify the conditions of shaping of attitudes towardsscience among people who meet popular scientific information every day.In the article some results of works on psychological tool designed to examinemany aspects of strongly scientistic worldview described as “scientotheism”were presented. During researches on the sample of 508 adult Poles, from theprimary set of questionnaire items we selected these which were characterizedby the highest level of accordance of examined people’s attitudes. Because ofthe high level of agreement/disagreement, answers connected with these itemscan be perceived as a sample survey of common convictions about the role ofthe elements of scientific system in the contemporary world.Analysis of collected data shown that examined people perceived scientific researchas rather useful activity which brought the real increase of knowledge about world, gave them tools to cope with common problems and had positiveinfluence on everyday life. On the other hand, common convictions of the examinedpeople were that there were phenomena which cannot be scientificallyexplained and that forecasts which said that we would achieve the full knowledgeabout the world could not be serious. Furthermore, respondents frequentlythought that science could only partially reduce common fears. Commonlythey contested also the statement that science could erase conflicts which occurredamong people.
Comparison of the EORTC and CUETO prognostic models in non-muscle-invasive bladder cancer
Authors: Kaprin A. D. , Apolikhin O. I. , Alekseev B. Ya. , Roshchin D. A. , Kachmazov A. A. , Perepechin D. V. , Golovashchenko M. P. , Deryagina D. M. 
Published: July 2018

Bladder cancer is one of the most common malignant diseases involving the urinary system. Accurate prediction of the disease course and outcome is crucial for choosing an appropriate treatment strategy in these patients. Currently, there are several prognostic models for predicting non-muscle invasive bladder cancer outcomes. The scoring systems developed by the European Organization for Research and Treatment of Cancer (EORTC) and the Spanish Urological Club for Oncological Treatment (CUETO) are the most widely used prognostic models for bladder cancer. Despite the undeniable merits of these scales, they need to be supplemented. Since the prognostic score has a direct impact on the treatment strategy, intensity and costs of postoperative follow-up, and outcome, its accuracy should be higher than it is now. Identifying the additional parameters that would increase the robustness of these models is one of the major challenges for researchers.The molecular and genetic characteristics of the tumor, that can be estimated after the first surgery, are probably the best candidates for this role. The main limitation of these prognostic models lies in the fact that they assess only morphological properties of the tumor, while the most important molecular characteristics are neglected. These scoring systems do not evaluate clinical factors, concomitant diseases, and iatrogenic complications occurring during the treatment of relapses. The assessment of molecular mechanisms and clinical characteristics underlying the development of non-muscle-invasive bladder cancer as well as identification of key molecular markers, that could complement the currently existing risk assessment models, are the most important goals for researchers dealing with bladder cancer. It will significantly improve predictive capabilities of these models, ensuring the choice of an optimal treatment strategy.
Adrenal metastases: clinical manifestations and surgical outcomes
Authors: Latypov V. R. , Popov O. S. , Latypova V. N. , Grishchenko M. Yu. 
Published: July 2018

Background. The adrenal glands are one of the most common sites of metastases in malignant disease, particularly lung cancer. The frequency of adrenal metastasis in patients with breast cancer and lung cancer reaches 39 and 35 % respectively.Materials and methods. A total of 156 patients with adrenal tumors underwent surgical treatment in the Siberian State Medical University between December 1998 and July 2017. The study included 16 (10.2 %) patients (9 males and 7 females) with adrenal metastases. The mean age of study participants was 57.6 years (range: 44–73 years).Results. By the moment of surgery, the mean metastatic adrenal tumor size was 4.9 ± 3.0 cm (range: 1.0–10.2 cm). Thirteen out of 16 patients had adrenal metastases from renal cell carcinoma, one patient – from colon cancer, one patient – from lung cancer, and one patient – from breast cancer. Nine patients had left-sided adrenal metastases, whereas six patients had right-sided adrenal metastases. Synchronous adrenal metastasis was detected in two cases: one patient had adrenal metastasis at the side of the renal tumor; the other one had bilateral renal cell carcinoma with both adrenal glands affected.We identified three main variants of the disease course according to prevailing clinical manifestations of adrenal metastasis: no manifestations, pain syndrome, and arterial hypertension.Seven participants had no clinical manifestations; of them, 6 patients had renal cell carcinoma, whereas 1 patient had breast cancer. The mean time between surgical removal of the primary tumor and detection of adrenal metastases was 24.1 months; the mean tumor size was 4.5 cm.Pain syndrome was observed in 5 patients. In three of them, adrenal metastases derived from renal cell carcinoma, in one patient – from lung cancer, and in one patient – from colon cancer. The mean time between removal of the primary tumor and detection of adrenal metastases was 19.8 months; the mean tumor size was 5.4 cm.Arterial hypertension was diagnosed in four patients. The mean time between removal of the primary tumor and identification of adrenal metastases was 27.3 months; the mean tumor size was 4.1 cm. The five-year overall survival rate in operated patient was 47.8 %.Conclusion. Regular examinations of patients after surgical treatment of malignant tumors are needed to detect adrenal metastases; surgery can extend the patient’s life. can extend the patient’s life.
THE EFFECTIVENESS OF HERBAL MOSQUITO COILS “MORIZENA” AGAINST Aedes Aegypti DEATH
Authors: Susilowati Rina Priastini , Darmanto Win , Aminah Nanik Siti 
Published: July 2018

It has been successfully found new herbal mosquito coils called “Morizena” made from Passiflora foetida leaf extract (40%), Chrysantemum cinerariaefolium flowers seed extract (40%), essential oils of leaves-stems of Cymbopogon nardus (20%). The herbal mosquito coils are more effective to kill Aedes aegypti compared to commercial synthetic mosquito coils made from Transfluthrin. Treatment of exposure to herbal mosquito coils “Morizena” on Aedes aegypti for 8 hours/day with concentration 500 ppm (P1), 1000 ppm (P2), 2000 ppm (P3), 3000 ppm (P4), 4000 ppm (P5) and treatment of exposure to synthetic mosquito coils Transfluthrin 2500 ppm (K1) as a positive control, and without treatment of exposure to mosquito coils (K0) as a negative control. Experimental animals used were adult Ae. aegypti mosquito with 25 mosquitoes in each treatment. Experimental design used is one-way Anova test with linear regression to calculate its LC50 and LC90. The results of test to herbal mosquito coils “Morizena” given for 8 hours/day obtained mortality of Ae. aegypti by 92% to a concentration of 3000 ppm (P4) and 100% to a concentration of 4000 ppm (P5) and 100% for test to synthetic mosquito coils transfluthrin 2500 ppm (K1). Ae. aegypti LC50 and LC90 value for treatment of exposure to herbal mosquito coils “Morizena” are 999 ppm and 2977 ppm. Treatment of herbal mosquito coils “Morizena” with graded doses up to 4000 ppm and synthetic mosquito coils Transfluthrin 2500 ppm causing an increase in the enzyme acetylcholinesterase activity of Ae. aegypti. The conclusion is based on the Ae. aegypti LC90 value is 2977 ppm, which means the effective dose of herbal mosquito coils “Morizena” to kill Ae. aegypti is 2977 ppm.
HUMAN RESOURCE SCORECARD DALAM PENDIDIKAN NONFORMAL DAN INFORMAL
Authors: Puspita Widya Ayu 
Published: July 2018

Human resource scorecard is a tool to record human resource performance in a card system, by focusing on long and short term and using financial and non financial indicators. There are four perspectives in this approach, which are learning and growth, internal business process, customer and finance. Human resource scorecard is not only a tactic measurement but a strategic management to manage long term strategies. This articles discusses how human resource scorecard can be implemented in the formal and nonformal organization comprehensively to increase human resource quality and to improve education organization, so that, it can give the best service to community.
STRATEGI PEMBELAJARAN PAUD MELALUI METODE DONGENG BAGI PENDIDIK PAUD
Authors: Kusmiadi Ade , Sriwahyuningsih Sriwahyuningsih , Nurfalah Yuyun 
Published: July 2018

Instructional strategy is one of important factors to achieve instructional objectives. This article discusses both strengthening of Early Childhood Education (ECE) teachers in implementing instructional strategy through story telling method and some consideration upon the selection of appropriate story telling for ECE. It is one of the effective methods improving childrenâ€™s competencies in many aspects. It could also improve the teachersâ€™ knowledge and stimulate their creativity in developing learning method.
TUTOR INTI SEBAGAI SOLUSI PERCEPATAN PENINGKATAN KOMPETENSI TENAGA PENDIDIK NONFORMAL
Authors: Samosir Chairuddin 
Published: July 2018

There is still a bad need to improve the competence of a large number of non-formal educators but the Government has limited budget and trainers to do formal trainings all over the country. This article purposes a cell system through a master tutor as an alternative training model to solve the problem. This model can be successfully implemented under sufficient support and supervision of The Education Office in district level, PTK-PNF Forum, BPKB, SKB and the Directorate of PTKPNF.
OPTIMALISASI PERAN TUTOR INTI SEBAGAI TIM TEACHING DAN PEER TUTORING
Authors: Syamsuddin Erman 
Published: July 2018

Non-formal Education (NFE) is still facing insufficient number and quality of tutors and thiese become serious obstacles in implementing NFE programs. Meanwhile a continous quality improvement of various NFE activities is required to meet the societyâ€™s needs. This article discusses the necessities of developing master tutors based on philosophical, legal, and empirical studies.
PEMBERDAYAAN MASYARAKAT ADAT TERPENCIL MELALUI MODEL PENDIDIKAN LUAR SEKOLAH
Authors: Hadiyanti Puji 
Published: July 2018

Empowering the community of remote custom is an effort to raise dignity and prestige of human to the real position. There are many challenges that must be faced especially in empowering potential that exists in human itself. Modeling out of school education tries to position itself as one of approaches that can be used in the effort of empowering the community of remote custom. Developing theori awareness in the importance of study process as an effort of behavior changes, then it will open their access toward an appropriate study process to their way of life and their requirement in order to increase their power, their cognitive, their psychology, their economic and their politic that is a form of done empowering. Although it cannot happen in short time, out of school education is believed will make them more adjustable toward environment changes.
Tunable band gap of Bi3+-doped anatase TiO2 for enhanced photocatalytic removal of acetaminophen under UV-visible light irradiation
Authors: Alzamly Ahmed , Hamed Fathalla , Ramachandran Tholkappiyan , Bakiro Maram , Ahmed Salwa Hussein , Mansour Shefaa , Salem Sahar , Abdul al Khaldiha , Al Kaabi Nawf Saif , Meetani Mohammed , Khaleel Abbas 
Published: July 2018

Abstract
A series of Bi3+-doped TiO2 photocatalysts has been prepared via the propylene oxide (PO) assisted sol-gel method. The effect of Bi3+ doping on structural surface morphology and optical properties of the as-prepared photocatalysts was characterized using UV-Visible (UV-Vis) diffuse reflectance spectroscopy, X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, Brunauer-Emmett-Teller for determination of the specific surface area and porosity, and X-ray photoelectron spectroscopy. Increasing the Bi3+ doping percentage up to 10 mole percent, resulted in all as-prepared photocatalysts exhibiting pure anatase phase upon calcination at 400 °C for 3 hours. A red shift in optical band gap measurements was observed with increasing Bi3+ ion percent doping, which led to extension of the photocatalysts' activity to the visible region. The enhanced photocatalytic activity for removal of the pharmaceutical compound acetaminophen under UV-Vis light irradiation was demonstrated by comparing bismuth doped as-prepared photocatalysts with pure TiO2 photocatalysts prepared under the same conditions. Based on experimental conditions, the highest activity was achieved using 10 mole percent Bi3+-doped photocatalyst, where over a period of 4 hours more than 98% acetaminophen removal was achieved.
Nitrogen removal and N2O emission by shunt distributing wastewater in aerated or non-aerated subsurface wastewater infiltration systems under different shunt ratios
Authors: Zheng Fanping , Zhao Yue , Li Zhiqi , Tan Chaoquan , Pan Jing , Fan Linlin , Xiao Lu , Hou Wanyuan 
Published: July 2018

Abstract
This study investigated matrix oxidation–reduction potential (ORP), nitrogen removal, N2O emission and nitrogen removal functional gene abundance in three subsurface wastewater infiltration systems (SWISs), named SWIS A (without aeration or shunt distributing wastewater), SWIS B (with shunt distributing wastewater) and SWIS C (with intermittent aeration and shunt distributing wastewater) under different shunt ratios. Aerobic conditions were produced at a depth of 50 cm and anoxic or anaerobic conditions were not changed at depths of 80 and 110 cm by aeration in SWIS C. High average removal rates of chemical oxygen demand (COD) (83.1% for SWIS B, 90.9% for SWIS C), NH3-N (74.3% for SWIS B, 90.8% for SWIS C) and total nitrogen (TN) (61.1% for SWIS B, 87.9% for SWIS C) were obtained under shunt ratios of 1:3 and 1:2 for SWIS B and C, respectively. The lowest N2O emission rate (28.4 mg/(m2 d)) and highest nitrogen removal functional gene abundances were achieved in SWIS C under a 1:2 shunt ratio. The results suggested intermittent aeration and shunt distributing wastewater combined strategy would enhance nitrogen removal and reduce N2O emission for SWISs.
Improved adsorption of Congo red by nanostructured flower-like Fe(II)–Fe(III) hydroxy complex
Authors: Sun Xiaoyan , Liu Zhongwu , Zheng Zhigang , Yu Hongya , Zeng Dechang 
Published: July 2018

Abstract
Amorphous Fe(II)–Fe(III) hydroxy complex with flower-like nanostructure was synthesized by ferric reduction using a microwave-assisted ethylene glycol approach. Here we investigated the correlation between its chemical composition and the removal rate for Congo red (CR) dye. The results showed that the amorphous complex had similar reduction and anion exchange capacities to the green rust. Due to the synergistic effect of attractive electrostatic interaction, anion exchange, ferrous redox and hydrogen bonding, the Fe(II)–Fe(III) hydroxy complex exhibited strong adsorption of CR with an estimated adsorption capacity up to 513 mg g−1. In contrast, the Fe(III) hydroxy complex had an adsorption capacity of 296 mg g−1 because of the predominant mechanism based on the electrostatic interaction. The present study provides a facile synthesis of nanostructured iron hydroxy complex, with superior performance in adsorbing CR.
Does influent COD/N ratio affect nitrogen removal and N2O emission in a novel biochar-sludge amended soil wastewater infiltration system (SWIS)?
Authors: Zheng Fanping , Tan Chaoquan , Hou Wanyuan , Huang Linli , Pan Jing , Qi Shiyue 
Published: July 2018

Abstract
Nitrogen removal and N2O emission of a biochar-sludge amended soil wastewater infiltration system (SWIS) with/without intermittent aeration under different influent COD/N ratios was investigated. Nitrogen removal and N2O emission were affected by influent COD/N ratio. Under a COD/N ratio between 1:1 and 15:1, average chemical oxygen demand (COD), NH4+-N and total nitrogen (TN) removal rates decreased with COD/N ratio increase in non-aerated SWISs amended with/without biochar-sludge; an increasing COD/N ratio hardly affected COD and NH4+-N removal in a biochar-sludge amended SWIS with intermittent aeration; the N2O emission rate decreased with COD/N ratio increase in the studied SWISs. The biochar-sludge amended SWIS with intermittent aeration achieved high COD (92.2%), NH4+-N (96.8%), and TN (92.7%) removal rates and a low N2O emission rate (10.6 mg/(m2 d)) under a COD/N ratio of 15:1, which was higher than those in non-aerated SWISs amended with/without biochar-sludge. Combining the biochar-sludge amended SWIS with intermittent aeration enhanced the number of nitrifying bacteria, denitrifying bacteria, nitrate reductase activities, nitrite reductase activities, and improved the abundance of nitrogen removal functional genes under a high influent COD/N ratio. The results suggested that the joint use of intermittent aeration and biochar-sludge in a SWIS could be an effective and appropriate strategy for improving nitrogen removal and reducing N2O emissions in treating high COD/N ratio wastewater.
Selection of quorum quenching (QQ) bacteria for membrane biofouling control: effect of different Gram-staining QQ bacteria, Bacillus sp. T5 and Delftia sp. T6, on microbial population in membrane bioreactors
Authors: Gül Bahar Yavuztürk , Imer Derya Yüksel , Park Pyung-Kyu , Koyuncu Ismail 
Published: July 2018

Abstract
This study aimed to address the gap in understanding how the microbial community present within quorum quenching-membrane bioreactor (QQ-MBRs) changes during the operations by investigating the behavior of two different types of QQ bacteria, Bacillus sp. T5 and Delftia sp. T6. The anti-biofouling effects of T5 and T6 in the QQ-MBR were 85% and 76%, respectively. According to the Illumina HiSeq results, when the QQ-MBR was operated with Gram-positive bacteria, T5, in the mixed liquor a reduction was observed in Gram-positive bacteria and Gram-negative bacteria population increased. In contrast, when the QQ-MBR was operated with Gram-negative bacteria, T6, Gram-negative bacteria population reduced and an increase in Gram-positive bacteria observed. As such, the outputs of the Illumina analysis revealed that use of Gram-negative QQ bacteria in the reactor induced a Gram-positive microbial community and vice versa. This indicates that a close interaction occurs between indigenous Gram-negative and positive bacterial phyla, and Bacillus sp. T5/Delftia sp. T6 is fundamental to the performance of MBRs. This is the first study demonstrating such a relationship and assistance selecting QQ bacteria/strategy in an effective way.
Co-digestion of microalga-bacteria biomass with papaya waste for methane production
Authors: Cea-Barcia Glenda , Pérez Jaime , Buitrón Germán 
Published: July 2018

AbstractThe anaerobic co-digestion of microalga-bacteria biomass and papaya waste (MAB/PW) was evaluated under semi-continuous conditions. Microalgae-bacteria biomass was obtained from a high rate algal pond fed with municipal wastewater and artificially illuminated. The co-digestion of MAB/PW was evaluated using a 1:1 (w/w) ratio and an organic loading rate of 1.1 ± 0.1 g COD/L/d. Enzymatic activity assays of papain were performed in the feeding to determine the activity of this enzyme in the substrate mixture. A methane yield of 0.55 L CH4/gVS and 68% of total volatile solid removal were observed. The volumetric productivity was 0.30 ± 0.03 L CH4/L/d with a methane content of 71%. It was observed that papaya waste was a suitable co-substrate because it maintained a low ammonium concentration, decreasing the risk of inhibition due to ammonia and then increasing the methane yield of the microalgae-bacteria biomass compared to the biomass alone. The pretreatment effect by the addition of papaya waste on the microalgae-bacteria biomass was supported by the papain activity remaining in the substrate.
Therapeutic Drug Monitoring in Pediatric IBD: Current Application and Future Perspectives
Authors: Lega S. , Bramuzzo M. , Dubinsky M.C. 
Published: July 2018

Background:
as the paradigm for IBD management is evolving from symptom control
to the more ambitious goal of complete deep remission, the concept of personalized medicine, as a
mean to deliver individualized treatment with the best effectiveness and safety profile, is becoming
paramount. Therapeutic drug monitoring (TDM) is an essential part of personalized medicine
and its role in the management of IBD patients is rapidly expanding.
<p>
Objective: to review the current knowledge that poses the rationale for the use of TDM, and the
present and future role of TDM-based approaches in the management of pediatric IBD.
<p>
Method: literature review.
<p>
Results: the concept of TDM has been introduced in the field of IBD along with thiopurines, over
a decade ago, and evolved around anti-TNF therapies. TDM-based strategies proved to be costeffective
in the management of patients with loss of response to biologics and, more recently,
proactive TDM to optimize drug exposure has been shown to reduce treatment failure and drug
adverse events. The role of TDM with new biologics and the usefulness of software-systems support
tools to guide drug dosing are now under investigation.
<p>
Conclusion: Therapeutic drug monitoring has the potential to maximize the cost-benefit profile of
therapies and is becoming an essential part of IBD management.
Synthesis of New 5-amino-7-(aryl)-1,2,3,7-tetrahydro-8-nitroimidazo[1,2-a]pyridine- 6-carboxamide and 6-amino-2,3,4,8-tetrahydro-9-nitro-8-(aryl)-1H-pyrido[1,2- a]pyrimidine-7-carboxamide Derivatives
Authors: Hosseini Fahimeh S. , Bayat Mohammad 
Published: July 2018

Aim and Objectives: Development of simple synthetic routes for widely used organic compounds
from readily available reagents is one of the major tasks in organic chemistry. Therefore, new approaches for
increasing the molecular diversity of simple starting materials, are needed. Herein, an efficient synthesis of
imidazo[1,2-a]pyridine, pyrido[1,2-a]pyrimidine and pyrido[1,2-a][1,3]diazepine derivatives is described.

Materials and Methods:

A one-pot, multi-component reaction of nitro ketene aminal derived from the addition
of various 1,n-diamines to 1,1-bis(methylthio)-2-nitroethene with cyanoacetamide and aromatic aldehydes is
described. The reactions are completed within 2-5 h, in ethanol at reflux, in good to high yields (70-93%). The
structures of products were deduced from their IR, mass, 1H NMR, and 13C NMR spectra.

Results:
Optimal reaction conditions for the synthesis of products were obtained, when ethanol was used as the
solvent at reflux. This protocol involves Michael reaction, imine–enamine tautomerization, and cyclization sequences.

Conclusion:
This work represents an efficient synthesis of imidazo[1,2-a]pyridine, pyrido[1,2-a]pyrimidine
and pyrido[1,2-a][1,3]diazepine derivatives via a one-pot, multi-component reaction. The advantages of this
protocol are mild conditions, easy accessibility of reactants, absence of catalyst, high atom economy, simple
work-up and purification process with no chromatographic technique.