bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topologies on quotient space of matrices via semi‐tensor product
Authors: Cheng Daizhan , Liu Zequn 
Published: September 2019

AbstractAn equivalence of matrices via semi‐tensor product (STP) is proposed. Using this equivalence, the quotient space is obtained. Parallel and sequential arrangements of the natural projection on different shapes of matrices lead to the product topology and quotient topology respectively. Then the Frobenious inner product of matrices is extended to equivalence classes, which produces a metric on the quotient space. This metric leads to a metric topology. A comparison for these three topologies is presented. Some topological properties are revealed.
DNA‐binding activity and cytotoxic and cell‐cycle arrest properties of some new coumarin derivatives: a multispectral and computational investigation
Authors: Khosravifar Fariba , Dehghan Gholamreza , Bidoki Seyed Kazem , Mahdavi Majid 
Published: September 2019

AbstractCoumarins are the most important class of natural compounds found widely in various plants. Many coumarin derivatives with different biological and pharmacological activities have been synthesized. In this study, the antiapoptotic and cytotoxic effects and DNA‐binding properties of some synthetic coumarin derivatives (4b, 4d, 4f, 4 g (DBP‐g), 4 h and 4j) against K562 cell lines were investigated using different techniques. MTT assay indicated that the DBP‐g compound was more active than other derivatives, with a IC50 value of 55 μM, and therefore this compound was chosen for further investigation. Apoptosis induction was assessed using acridine orange/ethidium bromide double‐staining and cell‐cycle analysis. In addition, in vitro DNA‐binding studies were carried out using ultraviolet–visible light absorption and fluorescence spectroscopy, as well as viscosity measurement and molecular modelling studies. In vitro results indicated that DBP‐g interacted with DNA through a groove‐binding mode with a binding constant (Kb) of 1.17 × 104 M−1. In agreement with other experimental data, molecular docking studies showed that DBP‐g is a minor groove binder. Overall, it can be concluded that DBP‐g could be used as an effective and novel chemotherapeutic agent.
Trends in intracranial meningioma incidence in the United States, 2004‐2015
Authors: Lin Dong‐Dong , Lin Jia‐Liang , Deng Xiang‐Yang , Li Wei , Li Dan‐Dong , Yin Bo , Lin Jian , Zhang Nu , Sheng Han‐Song 
Published: September 2019

AbstractBackgroundMeningioma incidence was reported to have risen substantially in the United States during the first decade of the 21st century. There are few reports about subsequent incidence trends. This study provides updated data to investigate trends in meningioma incidence by demographic and tumor characteristics at diagnosis in the United states from 2004 to 2015.MethodsTrends in meningioma incidence were analyzed using data from the Surveillance, Epidemiology, and End Results‐18 (SEER‐18) registry database of the National Cancer Institute. The joinpoint program was used to calculate annual percent change (APC) in incidence rates.ResultsThe overall incidence of meningioma increased by 4.6% (95% CI, 3.4‐5.9) annually in 2004‐2009, but remained stable from 2009 to 2015 (APC, 0; 95% CI, −0.8 to 0.8). Females (10.66 per 100 000 person‐years) and blacks (9.52 per 100 000 person‐years) had significant predominance in meningioma incidence. Incidence in many subgroups increased significantly up to 2009 and then remained stable until 2015. However, meningioma incidence in young and middle‐aged people increased significantly throughout the entire time period from 2004 to 2015 (APC: 3.6% for <20‐year‐olds; 2.5% for 20‐39‐year‐olds; 1.8% for 40‐59‐year‐olds). The incidence of WHO II meningioma increased during 2011‐2015 (APC = 5.4%), while the incidence of WHO III meningioma decreased during 2004‐2015 (APC = −5.6%).ConclusionIn this study, the incidence of meningioma was found to be stable in recent years. Possible reasons for this finding include changes in population characteristics, the widespread use of diagnostic techniques, and changes in tumor classification and risk factors in the US population.
Transcription factor E2F4 is a positive regulator of milk biosynthesis and proliferation of bovine mammary epithelial cells
Authors: Zhen Zhen , Zhang Minghui , Yuan Xiaohan , Li Meng 
Published: September 2019

AbstractThe transcription factor E2F4 is a key determinant of cell differentiation and cell‐cycle progression, but its function and regulatory mechanism are not completely understood. Here, we report that E2F4 acts as a positive regulator of the biosynthesis of milk components and proliferation of bovine mammary epithelial cells (BMECs). Overexpression of E2F4 in BMECs resulted in the upregulation of β‐casein, triglyceride, and lactose levels and increased cell proliferation, whereas E2F4 knockdown by small interfering RNA had the opposite effects. We further detected that overexpression of E2F4 significantly increased the messenger RNA expression of mTOR, SREBP‐1c, and Cyclin D1, and increased protein levels of SREBP‐1c, and Cyclin D1, and the ratio of p‐mTOR/mTOR, whereas E2F4 knockdown had the opposite effects. E2F4 was almost entirely located in the nucleus, and we further identified, via ChIP‐qPCR analysis, that mTOR, SREBP‐1c, and Cyclin D1 were E2F4 target genes, and exogenous administration of methionine, leucine, β‐estradiol, and prolactin markedly increased the protein levels of E2F4 and its binding to the promoters of these three genes. In summary, our data reveal that E2F4 responds to extracellular stimuli and regulates the expression of mTOR, SREBP‐1c, and Cyclin D1 for milk biosynthesis and proliferation of BMECs.
ING5 inhibits cancer aggressiveness by inhibiting Akt and activating p53 in prostate cancer
Authors: Barlak Neslisah , Capik Ozel , Sanli Fatma , Kilic Ahsen , Aytatli Abdulmelik , Yazici Aysenur , Ortucu Serkan , Ittmann Michael , Karatas Omer Faruk 
Published: September 2019

AbstractProstate cancer (PCa) is one of the most common types of cancer in men. In several recent studies, chromosomal deletions in the q arm of chromosome 2, where ING5 resides within, have been identified in various cancer types including PCa. In this study, we investigate the role of ING5 as a tumor suppressor in PCa. We examined the expression level of ING5 in tissue samples and cell lines using quantitative real‐time polymerase chain reaction and western blot analysis. We tested the in vitro tumor suppressor potential of ING5 in PC3 and LNCaP cells stably overexpressing it using cell viability, colony formation, migration, invasion, and apoptosis assays. We then investigated the effects of ING5 on the Akt and p53 signaling using western blot analysis. We show that ING5 is significantly downregulated in PCa tumor tissue samples and cell lines compared with the corresponding controls. In vitro assays demonstrate that ING5 effectively suppresses proliferative, clonogenic, migratory, and invasive potential and induce apoptosis in PCa cells. ING5 may potentially exert its anti‐tumor potential by inhibiting AKT and inducing p53 signaling pathways. Our findings demonstrate that ING5 possesses tumor suppressor roles in vitro, pointing its importance during the prostatic carcinogenesis processes.
Spinel‐Type Mixed Metal Sulfide NiCo2S4 for Efficient Photocatalytic Reduction of CO2 with Visible Light
Authors: Xiong Zhuang , Huang Lijuan , Peng Junwen , Hou Yidong , Ding Zhengxin , Wang Sibo 
Published: September 2019

AbstractMixed metal oxides with a spinel structure have exhibited great opportunities for photocatalytic CO2 reduction; however, the abilities of their sulfide counterparts in this promising area are much less reported. Herein, we demonstrate the synthesis of a ternary metal sulfide, namely NiCo2S4, and its first application to catalyze the CO2 photoreduction reaction under visible light irradiation. The NiCo2S4 material is prepared through a coupled solvothermal‐ion exchange strategy, and is fully checked by diverse characterizations, including X‐ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X‐ray photoelectron spectroscopy (XPS), energy‐dispersive X‐ray spectroscopy (EDX) and N2 sorption measurements. Under visible light irradiation in a classic tandem photochemical system, this non‐noble‐metal NiCo2S4 catalyst affords a considerable activity and high stability for CO2 deoxygenative reduction, delivering a high CO‐liberating rate of 43.5 μmol mg−1 h−1. The in‐situ PL and transient photocurrent measurements reveal that the spinel catalyst can hamper recombination and accelerate transfer of light‐excited charge carriers, and thus boosting the CO2 reduction reaction. At last, a possible mechanism of the NiCo2S4‐catalyzed CO2 photoreduction reaction is proposed.
Electrochemical Signature of Escherichia coli on Nickel Micropillar Array Electrode for Early Biofilm Characterization
Authors: Astorga Solange E. , Hu Liang Xing , Marsili Enrico , Huang Yizhong 
Published: September 2019

AbstractBiofilms are sessile microbial communities living at interfaces, in which the extracellular matrix is responsible for the mechanical stability and adhesion to surfaces. Transition from planktonic to attached cells is a key step in the biofilm formation process. Monitoring of this transition is needed to prevent contamination of biomedical devices and mitigate microbially influenced corrosion. Under anoxic local conditions and in the presence of an exogenous redox mediator, biofilms can divert part of the electron flow associated with catabolism to electrodes maintained at a defined potential. Extracellular electron transfer (EET) follows upon the attachment of planktonic cells to the surface. Modification of the electrode increases bacterial attachment, thus allowing early bioelectrochemical detection of the biofilm. Here, we report a Ni electrode micropillar array to detect early attachment of Escherichia coli biofilm through mediated EET in potentiostat‐controlled electrochemical cells. The biofilm‐surface interaction is studied by using electrochemical impedance spectroscopy (EIS) at different potentials and temperatures over 24 h. The analysis of the EIS signature highlights the effect of temperature on mediated EET in biofilms. These results demonstrate that micropillared electrodes allow earlier biofilm detection than flat electrodes, which is relevant to biofilm sensing and investigation of microbially influenced corrosion in drinking water systems and biomedical devices.
Internet‐Challenges
Authors: Prechtl Markus 
Published: September 2019

ZusammenfassungJugendliche präsentieren und verfolgen substanzbezogene Challenges auf YouTube. Der Beitrag informiert über die populäre Chili Challenge, Cinnamon Challenge, Deo Challenge, Banana‐and‐Sprite Challenge, das Vodka Eyeballing etc., über deren Gesundheitsgefahren, insofern verlässliche Befunde vorliegen, und über deren Häufigkeit auf YouTube.
Structure‐Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases
Authors: Małecki Piotr H. , Rüger Nicole , Roatsch Martin , Krylova Oxana , Link Andreas , Jung Manfred , Heinemann Udo , Weiss Manfred S. 
Published: September 2019

AbstractHuman histone demethylases are known to play an important role in the development of several tumor types. Consequently, they have emerged as important medical targets for the treatment of human cancer. Herein, structural studies on tetrazolylhydrazide inhibitors as a new scaffold for a certain class of histone demethylases, the JmjC proteins, are reported. A series of compounds are structurally described and their respective binding modes to the KDM4D protein, which serves as a high‐resolution model to represent the KDM4 subfamily in crystallographic studies, are examined. Similar to previously reported inhibitors, the compounds described herein are competitors for the natural KDM4 cofactor, 2‐oxoglutarate. The tetrazolylhydrazide scaffold fills an important gap in KDM4 inhibition and newly described, detailed interactions of inhibitor moieties pave the way to the development of compounds with high target‐binding affinity and increased membrane permeability, at the same time.
Cu2O Nanocrystals‐Catalyzed Photoredox Sonogashira Coupling of Terminal Alkynes and Arylhalides Enhanced by CO2
Authors: Shanmugam Munusamy , Sagadevan Arunachalam , Charpe Vaibhav Pramod , Pampana V. Kishore Kumar , Hwang Kuo Chu 
Published: September 2019

AbstractHerein the first visible‐light‐activated Sonogashira C−C coupling reaction at room temperature catalyzed by single‐metal heterogeneous Cu2O truncated nanocubes (Cu2O TNCs) was developed. A wide variety of aryl halides and terminal alkynes worked well in this recyclable heterogeneous photochemical process to form the corresponding Sonogashira C−C coupling products in good yields. Mechanistic control studies indicated that CO2 enhances the formation of light‐absorbing heterogeneous surface‐bound CuI‐phenylacetylide (λmax=472 nm), which further undergoes single‐electron transfer with aryl iodides/bromides to enable Sonogashira C
−Csp bond formation. In contrast to literature‐reported bimetallic TiO2‐containing nanoparticles as photocatalyst, this work avoided the need of cocatalysis by TiO2. Single‐metal CuI in Cu2O TNCs was solely responsible for the observed C
−Csp coupling reactions under CO2 atmosphere.
Error probability and channel capacity analysis of wireless system over inverse gamma shadowed fading channel with selection diversity
Authors: Pant Diwaker , Chauhan Puspraj Singh , Soni Sanjay Kumar 
Published: September 2019

SummaryIn this paper, we present an analytical framework to analyse the error probability and the channel capacity of the inverse gamma (I‐Gamma) shadowed fading channel. First, the work discusses the utility of the I‐Gamma over log‐normal (LN) and gamma fading models where the closeness of I‐Gamma with other existing shadowing models is carried out. Utilising the probability density function (PDF) of the I‐Gamma shadowed fading channel, various metrics of the communication system, namely, the average symbol error probability (SEP), the channel capacity under optimal rate adaptation (ORA), channel inversion with fixed rate (CIFR), and truncated CIFR (TIFR) are derived. Further, the work is extended to derive a novel selection combining (SC) PDF, and the analytical results for the SEP and the channel capacity of SC diversity are presented. Furthermore, we also provide simpler asymptotic expressions for the average SEP. In addition, the simplified high and low signal‐to‐noise‐ratio (SNR) solutions to channel capacity are also provided. The derived mathematical formulations have been endorsed by comparing with Monte Carlo simulations.
Development of a mono‐specific anti‐VEGF bivalent nanobody with extended plasma half‐life for treatment of pathologic neovascularization
Authors: Sadeghi Amir , Behdani Mahdi , Muyldermans Serge , Habibi‐Anbouhi Mahdi , Kazemi‐Lomedasht Fatemeh 
Published: September 2019

AbstractVascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis within solid cancers. Thus, targeting VEGF might be part of a feasible therapy for treating pathological neovascularization, and nanobodies − derived from heavy chain‐only antibodies occurring within Camelidae − are a novel class of nanometer‐sized antibodies possessing unique properties that could be developed into a promising therapeutic. However, nanobodies have a very short half‐life in vivo due to their small size. Development of a bivalent nanobody is one way to remediate the half‐life problem of nanobodies. Two identical anti‐VEGF nanobodies were connected using the hinge region of llama IgG2c. The recombinant plasmid (pHEN6c‐bivalent nanobody) was transformed into E.coli WK6 cells and expression of the bivalent nanobody construct was induced with 1mM Isopropyl β‐D‐1‐thiogalactopyranoside (IPTG). Recombinant bivalent nanobody was purified using nickel affinity chromatography and its activity on human endothelial cells was assessed using 3‐(4,5‐Dimethylthiazol‐2‐yr)‐2,5‐diphenyltetrazolium bromide (MTT), tube formation, and cell migration assays. The pharmacokinetic study was performed after intravenous (i.v.) injection of recombinant bivalent nanobody into six‐week‐old C57BL/6 mice. Recombinant bivalent nanobody performed significantly better than monovalent nanobody in inhibiting proliferation, tube formation, and migration of human endothelial cells. Pharmacokinetic results showed a 1.8‐fold longer half‐life of bivalent nanobody in comparison with the monovalent nanobody. These results underscore the potential of recombinant anti‐VEGF bivalent nanobody as a promising tool for development of a novel therapeutic with an extended plasma half‐life for VEGF‐related diseases.
Linking pollen foraging of megachilid bees to their nest bacterial microbiota
Authors: Voulgari‐Kokota Anna , Ankenbrand Markus J. , Grimmer Gudrun , Steffan‐Dewenter Ingolf , Keller Alexander 
Published: September 2019

AbstractSolitary bees build their nests by modifying the interior of natural cavities, and they provision them with food by importing collected pollen. As a result, the microbiota of the solitary bee nests may be highly dependent on introduced materials. In order to investigate how the collected pollen is associated with the nest microbiota, we used metabarcoding of the ITS2 rDNA and the 16S rDNA to simultaneously characterize the pollen composition and the bacterial communities of 100 solitary bee nest chambers belonging to seven megachilid species. We found a weak correlation between bacterial and pollen alpha diversity and significant associations between the composition of pollen and that of the nest microbiota, contributing to the understanding of the link between foraging and bacteria acquisition for solitary bees. Since solitary bees cannot establish bacterial transmission routes through eusociality, this link could be essential for obtaining bacterial symbionts for this group of valuable pollinators.Open Research BadgesThis article has earned an Open Data Badge for making publicly available the digitally‐shareable data necessary to reproduce the reported results. The data is available at https://www.ebi.ac.uk/ena/data/view/PRJEB27223, https://www.ebi.ac.uk/ena/data/view/PRJEB31610, and https://doi.org/10.5061/dryad.qk36k8q
First record of Oziroë argentinensis (Lillo & Hauman) Speta (Asparagaceae) for Brazil
Authors: de Melo Pablo Hendrigo Alves , Lombardi Julio Antonio 
Published: September 2019

AbstractWe report the first record of Oziroë argentinensis (Asparagaceae) for Brazil, previously known from Paraguay, Bolivia, and Argentina. The plant was collected in the state of Mato Grosso do Sul, growing between limestone rocks, and is the first record of any species of Oziroë on this substrate.
Flexible covariance dynamics, high‐frequency data, and optimal futures hedging
Authors: Lai Yu‐Sheng 
Published: September 2019

AbstractThis paper investigates the out‐of‐sample performance of hedged portfolios constructed using a novel rotated ARCH (RARCH) model class, which enables flexible covariance dynamics for spot and futures returns. The model's empirical fit can be significantly improved when it incorporates rotated realized covariance matrix measures. The empirical results suggest that a highly risk‐averse hedger implementing the restricted RARCH model would be willing to pay substantial switching fees to capture the incremental gains generated by the flexible and informative alternative; this thus supports the economic importance of incorporating high‐frequency data into flexible RARCH modeling processes for the construction of optimal hedged portfolios.
Effects of forestry on summertime low flows and physical fish habitat in snowmelt‐dominant headwater catchments of the Pacific Northwest
Authors: Gronsdahl Stefan , Moore R. Dan , Rosenfeld Jordan , McCleary Rich , Winkler Rita 
Published: September 2019

AbstractPeriods of summertime low flows are often critical for fish. This study quantified the impacts of forest clear‐cutting on summertime low flows and fish habitat and how they evolved through time in two snowmelt‐dominant headwater catchments in the southern interior of British Columbia, Canada. A paired‐catchment analysis was applied to July–September water yield, the number of days each year with flow less than 10% of mean annual discharge, and daily streamflow for each calendar day. The postharvest time series were divided into treatment periods of approximately 6–10 years, which were analysed independently to evaluate how the effects of forestry changed through time. An instream flow assessment using a physical habitat simulation‐style approach was used to relate streamflow to the availability of physical habitat for resident rainbow trout. About two decades after the onset of logging and as the extent of logging increased to approximately 50% of the catchments, reductions in daily summertime low flows became more significant for the July–September yield (43%) and for the analysis by calendar day (11–68%). Reductions in summertime low flows were most pronounced in the catchment with the longest postharvest time series. On the basis of the temporal patterns of response, we hypothesize that the delayed reductions in late‐summer flow represent the combined effects of a persistent advance in snowmelt timing in combination with at least a partial recovery of transpiration and interception loss from the regenerating forests. These results indicate that asymptotic hydrological recovery as time progresses following logging is not suitable for understanding the impacts of forest harvesting on summertime low flows. Additionally, these reductions in streamflow corresponded to persistent decreases in modelled fish habitat availability that typically ranged from 20% to 50% during the summer low‐flow period in one of the catchments, suggesting that forest harvest may have substantial delayed effects on rearing salmonids in headwater streams.
Computer‐assisted psychological assessment and psychotherapy for collegians
Authors: Heesacker Martin , Perez Caroline , Quinn Molly S. , Benton Sherry 
Published: September 2019

AbstractObjectiveThis article reviews research on computerized and computer‐assisted psychological assessment and psychotherapy for college and university students.MethodPublished reviews of outcome research on the topic are reviewed, along with individual clinical trials and other relevant studies not covered by reviews, as well as reviews of closely‐related research.ResultsComputer‐assisted assessment and psychotherapy have proven effective with collegians across samples, nations, and presenting concerns.ConclusionsCurrently‐available digital technologies can address these mental health service delivery challenges: cost, limited human resources, failure of students to seek help, stigmatization of collegians seeking help, premature termination, inadequate process and outcome data to assess and improve treatment effectiveness, and lack of real‐time data‐based treatment selection.