bluuebunny/crossref_metadata_2025_split huggingface dataset:
Backshoring readiness
Authors: Nujen Bella Belerivana , Mwesiumo Deodat Edward , Solli-Sæther Hans , Slyngstad Andrea Blindheim , Halse Lise Lillebrygfjeld 
Published: November 2018

PurposeThe purpose of this study is to delineate key aspects of backshoring readiness and discuss how such aspects contribute to a smooth shift-back from global sourcing operations. It aims to answer the following questions: which factors constitute backshoring readiness and how these factors affect the backshoring transition.Design/methodology/approachBased on theory departure from the organizational readiness field and the emerging field on backshoring, a conceptual model is developed. A multiple qualitative case study is then conducted to exemplify the backshoring readiness factors delineated in the study.FindingsThe study indicates that due to previous outsourcing, limitations concerning the availability of firms’ capabilities are affected by ownership structures and that backshoring appears to be time-sensitive. The study delineates three key aspects of backshoring readiness and proposes a comprehensive understanding of readiness as an important construct to enhance successful backshoring.Research limitations/implicationsThe findings are limited by the nature of this conceptual study, the restriction to a high-cost context and the small number of cases. Therefore, conclusions and proposed recommendations need to be further investigated in preferably larger samples of case studies.Practical implicationsBy introducing contextual variables that go beyond traditional cost considerations, this work should be of special interest for both practitioners and academics, because the absorptive capacity for the exploitation of cutting-edge knowledge is globally scarce and hence rather expensive in Western countries compared with traditionally low-cost countries. Another practical contribution of this study is the conceptual backshoring readiness framework itself, as it can guide firms acquainting themselves with the resource availability in their home environment.Originality/valueThe research defines key resources needed to facilitate backshoring readiness in a conceptual framework developed from literature, which is then exemplified by a case study. This framework conceptualizes backshoring readiness as aspects of requirements to knowledge, technology and supplier infrastructures. Furthermore, the readiness framework developed provides firms and their managers with six recommendations that can enable a rigorous evaluation of a firm’s readiness to embark on backshoring and reflect on the aspect of fitness of its current strategies.
A safety marketing stimuli-response model of passenger behaviour in the ferry context
Authors: Lu Chin-Shan , Poon Ho Yee , Weng Hsiang-Kai 
Published: November 2018

Purpose
This study aims to propose a safety marketing stimuli-response model to explain passengers’ safety behavior in the ferry services context.

Design/methodology/approach
Structural equation modeling was conducted to examine the impact of safety marketing stimuli on passengers’ safety awareness and behavior by using data obtained from a survey of 316 ferry passengers in Hong Kong.

Findings
The authors found that passengers’ perceptions of ferry safety marketing stimuli positively affected their safety awareness and safety awareness positively affected passengers’ safety behaviors. Specifically, they found that safety awareness played a mediating role in the relationship between ferry safety marketing stimuli and passengers’ safety behaviors.

Practical/implications
The empirically validated scales can be adapted to practices of safety marketing, while providing helpful information for ferry operators to evaluate their efforts of safety marketing and implications for improvement.

Originality/value
According to the authors' knowledge, this study is one of the first attempts to fill this research gap by empirically validating and theoretically conceptualizing measures of safety marketing stimuli based on the marketing stimulus-response model.
Image processing procedure to quantify the internal structure of porous asphalt concrete
Authors: Ahmad Kabiru Abdullahi , Abdul Hassan Norhidayah , Abdullah Mohd Ezree , Bilema Munder A.M. , Usman Nura , Al Allam Al Allam Musbah , Hainin Mohd Rosli Bin 
Published: November 2018

Purpose
In order to fully understand the properties of porous asphalt, investigation should be conducted from different point of views. This is from the fact that porous asphalt mixture designed with the same aggregate gradation and air void content can give different infiltration rate due to the different formation of the internal structure. Therefore, the purpose of this paper is to investigate the micro-structural properties and functional performance of porous asphalt simultaneously.

Design/methodology/approach
The aim is to develop imaging techniques to process and analyze the internal structure of porous asphalt mixture. A few parameters were established to analyze the air void properties and aggregate interlock within the gyratory compacted samples captured using a non-destructive scanning technique of X-ray computed tomography (CT) throughout the samples. The results were then compared with the functional performance in terms of permeability. Four aggregate gradations used in different countries, i.e. Malaysia, Australia, the USA and Singapore. The samples were tested for resilient modulus and permeability. Quantitative analysis of the microstructure was used to establish the relationships between the air void properties and aggregate interlock and the resilient modulus and permeability.

Findings
Based on the results, it was found that the micro-structural properties investigated have successfully described the internal structure formation and they reflect the results of resilient modulus and permeability. In addition, the imaging technique which includes the image processing and image analysis for internal structure quantification seems to be very useful and perform well with the X-ray CT images based on the reliable results obtained from the analysis.

Research limitations/implications
In this study, attention was limited to the study of internal structure of porous asphalt samples prepared in the laboratory using X-ray CT but can also be used to assess the quality of finished asphalt pavements by taking core samples for quantitative and qualitative analysis. The use of CT for material characterization presents a lot of possibilities in the future of asphalt concrete mix design.

Originality/value
Based on the validation process which includes comparisons between the values obtained from the image analysis and those from the performance test and it was found that the developed procedure satisfactorily assesses the air voids distribution and the aggregate interlock for this reason, it can be used.
Intrapulmonary lymph node metastasis is common in clinically staged IA adenocarcinoma of the lung
Authors: Zhang DengGuo , Chen XianChao , Zhu Daxin , Qin Changlong , Dong Jingsi , Qiu Xiaoming , Fan Mingyu , Zhuo QingHua , Tang XiaoJun 
Published: November 2018

BackgroundIntrapulmonary lymph nodes (LNs, stations 11–14) are usually omitted in postoperative pathological examination. Some non‐small cell lung cancer (NSCLC) patients with intrapulmonary LN metastasis are incorrectly diagnosed as N0 cases. Furthermore, underestimation of intrapulmonary LN involvement in clinically early stage NSCLC may lead to the incorrect choice of surgical procedure: lobectomy or sublobar resection. This study was conducted to determine the status of intrapulmonary LN involvement in clinically staged IA (c‐T1N0M0) peripheral adenocarcinoma of the lung.MethodsSeventy‐five lobectomy specimens of c‐T1N0M0 peripheral adenocarcinoma of the lung were carefully dissected to find intrapulmonary LNs. The longest diameter of each intrapulmonary LN was measured and sent for pathological examination, together with hilar and mediastinal LNs, to investigate the relationship between LN metastasis and primary tumor size.ResultsIntrapulmonary LN metastasis was detected in 22.7%(17/75) of patients. Positive LNs were detected in 21.7% (10/46) of T1b patients and 45% (11/24) of T1c patients, while no metastasis (0/5) was observed in T1a patients (P = 0.036). The mean longest diameter of the 17 involved intrapulmonary LNs was only 6.5 ± 2.1 mm, which was not significantly different to the size of negative intrapulmonary LNs (5.2 ± 1.4 mm).ConclusionsIntrapulmonary LN metastasis is common in clinically staged IA peripheral adenocarcinoma of the lung. LN metastasis is related to tumor size, and this should be taken into account to determine appropriate surgical procedures and postoperative treatment. Computed tomography is not a reliable method to judge LN metastasis, particularly intrapulmonary LN metastasis.
The Loss of Information Associated with Binary Audit Reports: Evidence from Auditors' Internal Control and Going Concern Opinions
Authors: Christensen Brant E. , Neuman Stevanie S. , Rice Sarah C. 
Published: November 2018

ABSTRACTThis study provides evidence that binary signals in audit reports are unable to fully communicate underlying risks that are inherently continuous in nature. Specifically, we find that companies whose audit reports signal an improvement in internal control effectiveness relative to the prior year are still more likely to subsequently restate the current year's financial statements than companies with no material weaknesses in either year. Similarly, companies deemed to no longer have substantial doubt of continuing as a going concern are still more likely to declare bankruptcy than companies with no going concern opinion in either year. Results in both settings suggest the presence of residual risk that cannot be communicated through a binary audit report, despite the fact that auditors recognize the risk, as evidenced by higher audit fees and longer audit report lags. Our findings are strongest when the reported improvement is more pronounced, and our results hold in matched samples. Our study provides empirical evidence that supports recent regulatory efforts to improve the content of the audit report and offers suggestions for future research.
Risk and Feminist Utopia: Radicalizing the Future
Authors: Cortiel Jeanne 
Published: November 2018

AbstractRisk has taken over the world as the major way of conceptualizing the future as bleak, if one follows Ulrich Beck’s claim in World at Risk (2007). However, there is also a distinctly utopian strand in American risk discourse, one that has, from the outset, been linked to feminist perspectives. Indeed, when risk entered American culture in the 19th century, immediately women’s rights philosophy began to draw on futures shaped by risk, establishing self‐ownership and agency in a context that denied such freedom to women and non‐white men. This article explores connections between risk, futurity, agency, and selfhood as expressed in feminist thought, drawing a line between Margaret Fuller’s political essay Woman in the Nineteenth Century (1845), Joanna Russ’s science fiction novel The Female Man (1975), and Mary Daly’s radical feminist manifesto Quintessence: Realizing the Archaic Future (1998). The aim is not to develop a narrative of development but to see how risk has become useful in shaping distinctly feminist visions of the future. More specifically, I would like to see how risk‐taking has enabled feminist social dreaming. It is precisely this groundedness in risk that allows feminist utopian visions to remain productive in popular culture beyond feminist discourse. When, for example, the movie Alien (1979, dir. Ridley Scott) introduced a female protagonist to a science fiction/horror action plot, it drew on feminist utopian narrative patterns grounded in risk and risk‐taking. Feminist utopian visions as well as their continuations in popular culture thus bring out the subversive potential of risk for feminist theory and practice.
An Exploration of Femininity, Masculinity, and Racial Prejudices in Herland
Authors: Bowers Elinor 
Published: November 2018

AbstractCharlotte Perkins Gilman (1860–1935) helped spearhead the fin de siècle and early 20th‐century women’s rights movement and significantly contributed to the feminist literary genre with The Yellow Wallpaper (1892). Despite her dedication to the women’s movement and contributions to feminist literature, her novel Herland (1915) features problematic undertones of racism, elitism, and masculine degradation. Within recent years, feminism has become a term that is synonymous with inclusivity, with a focus on intersectionality and the rights of not only women but others who have been disenfranchised by race, religious affiliation, sexuality, socioeconomic status, or gender identification. Given modern feminism’s focus on diversity, the racist undertones and focus on gender separatism in Herland places Gilman outside the feminist literary genre, particularly as it has been defined in recent decades.
3D organ modeling with open‐source software
Authors: Cross Devon E. , Bauer Tyler M. , Tchantchaleishvili Vakhtang 
Published: November 2018

AbstractTo date, 3D organ modeling has not reached widespread clinical use, despite showing promise in medical literature. The majority of anatomic modeling that is presented in the literature is performed with proprietary software, presenting certain barriers to use, such as price for usage rights. Open‐source software not only circumvents this barrier, but also often provides greater customization offered by global communities. In this proof‐of‐concept experiment, a HeartMate II LVAD inflow cannula was “virtually fit” in a patient’s left ventricle using only open‐source software. Open‐source programs provide a legitimate alternative to the proprietary software options.
Clinical and translational pharmacological aspects of the management of fibrous dysplasia of bone
Authors: Rotman Marlous , Hamdy Neveen Agnes Therese , Appelman‐Dijkstra Natasha M. 
Published: November 2018

Fibrous dysplasia (FD) is a genetic, noninheritable rare bone disease caused by a postzygotic activating mutation of the α subunit of the stimulatory G‐protein causing increased abnormal bone formation leading to pain, deformity and fractures. To date, no cure has been identified for FD/McCune–Albright syndrome (MAS) and treatment is symptomatic and aimed at decreasing pain and/or local bone turnover. Various drugs have been used to achieve clinical improvement in FD/MAS patients including bisphosphonates and denosumab, however further translational studies are also warranted to address unresolved pathophysiological issues and explore novel pharmacological targets for the management of FD/MAS.In this article, we review literature on the medical treatment of FD/MAS, discuss the unresolved pathophysiological issues and explore novel pharmacological targets for the management of FD/MAS.
Risk factors associated with pseudoaldosteronism in patients with chronic hepatitis: A retrospective cohort study
Authors: Komatsu Akihiro , Yoshino Tetsuhiro , Suzuki Takeshi , Nakamura Tomonori , Kanai Takanori , Watanabe Kenji 
Published: November 2018

AbstractGlycyrrhizin is used to treat chronic hepatitis, but it also plays an important role in pseudoaldosteronism. Multidrug resistance‐associated protein 2 is important for glycyrrhizin excretion. Dysfunction of this transporter increases the serum levels of direct bilirubin, glycyrrhizin and its metabolites. Hence, elevated direct‐bilirubin levels could predict the risk of pseudoaldosteronism. This study aimed to evaluate the relationship between elevated direct‐bilirubin levels and hypokalaemia, which is the most sensitive marker of pseudoaldosteronism. This retrospective cohort study was conducted in a Japanese university hospital. The occurrence of hypokalaemia is defined as a serum potassium level of ≤3.5 mEq/L after the administration of a glycyrrhizin‐containing medication, and a further decline of ≥0.5 mEq/L or an increase of ≥0.5 mEq/L after discontinuing the glycyrrhizin‐containing medication was examined in patients with chronic hepatitis between January 2009 and December 2015. This analysis involved 1392 patients, including 596 women. Hepatitis C virus infections were the most common cause of chronic hepatitis in this study. Seventy‐nine patients received glycyrrhizin (exposed group; mean age: 60.5 ± 14.2) and 1313 did not receive glycyrrhizin (control group; mean age: 58.3 ± 15.8 years). Synergistic effects of glycyrrhizin‐containing medications and elevated direct‐bilirubin levels were associated with hypokalaemia. Elevated direct‐bilirubin levels and hypoalbuminaemia were associated with hypokalaemia in the exposed group. Older age, female sex, high daily glycyrrhizin dosage, longer duration of glycyrrhizin intake, and potassium‐lowering medications were not associated with hypokalaemia after the model adjustment. Elevated direct‐bilirubin levels and hypoalbuminaemia may predict pseudoaldosteronism caused by glycyrrhizin.
Computational methods and tools to predict cytochrome P450 metabolism for drug discovery
Authors: Tyzack Jonathan D. , Kirchmair Johannes 
Published: November 2018

AbstractIn this review, we present important, recent developments in the computational prediction of cytochrome P450 (CYP) metabolism in the context of drug discovery. We discuss in silico models for the various aspects of CYP metabolism prediction, including CYP substrate and inhibitor predictors, site of metabolism predictors (i.e., metabolically labile sites within potential substrates) and metabolite structure predictors. We summarize the different approaches taken by these models, such as rule‐based methods, machine learning, data mining, quantum chemical methods, molecular interaction fields, and docking. We highlight the scope and limitations of each method and discuss future implications for the field of metabolism prediction in drug discovery.
Nonhypoxic pharmacological stabilization of Hypoxia Inducible Factor 1α: Effects on dopaminergic differentiation of human neural stem cells
Authors: Hey Sabine Morris , Jensen Pia , Ryding Matias , Martínez Serrano Alberto , Kristensen Bjarne W. , Meyer Morten 
Published: November 2018

AbstractParkinson's disease is a neurodegenerative disease resulting in degeneration of midbrain dopaminergic neurons. Exploratory studies using human foetal tissue or predifferentiated stem cells have suggested that intracerebral transplantation of dopaminergic precursor cells may become an effective treatment for patients with Parkinson's disease. However, strategies for dopaminergic stem cell differentiation vary widely in efficiency, and better methods still need to be developed. Hypoxia Inducible Factor 1 (HIF‐1) is a transcription factor involved in the regulation of genes important for cellular adaption to hypoxia and low glucose supply. HIF‐1 is to a large degree regulated by the availability of oxygen as in its presence, the subunit HIF‐1α is degraded by HIF prolyl hydroxylase enzymes (HPHs). Stabilization of HIF‐1α through inhibition of HPHs has been shown to increase dopaminergic differentiation of stem cells and to protect dopaminergic neurons against neurotoxins. This study investigated the effects of noncompetitive (FG‐0041) and competitive (Compound A and JNJ‐42041935) HIF‐1α stabilizing compounds on the dopaminergic differentiation of human neural stem cells. Treatment with all HPH inhibitors at high oxygen tension (20%) resulted in HIF‐1α stabilization as assessed by immunocytochemistry for HIF‐1α and detection of increased levels of vascular endothelial growth factor in the conditioned culture medium. Following 10 days of HIF‐1α stabilization, the cultures displayed a slightly reduced proliferative activity and significantly increased relative levels of tyrosine hydroxylase‐positive dopaminergic neurons. In conclusion, HIF‐1α stabilization may represent a promising strategy for the generation of dopaminergic neurons intended for use in experimental in vitro studies and cell replacement therapies.
Onychoscopy of non‐infectious nail abnormalities in patients after allogeneic haematopoietic stem cell transplantation
Authors: Szlauer‐Stefańska A. , Kamińska‐Winciorek G. , Giebel S. 
Published: November 2018

AbstractNail abnormalities after allogeneic haematopoietic stem cell transplantation procedure (alloHSCT) are often reported. Usually, they are related to chronic graft‐versus‐host disease (cGvHD). So far, only clinical manifestations of selected nail abnormalities have been described, without the presentation of dermoscopic images. In this article, we present morphologic and dermoscopic manifestations of potential non‐infectious nail abnormalities in patients after alloHSCT procedure based on reviewed literature and our own experience with dermoscopic iconography. In majority of studies published till now, nail changes are not connected to severity of other cGvHD symptoms; however, e.g. the presence of pterygium inversum unguis may be an indicator of lung dysfunction. As nail changes may be an early sign of cGvHD and always present in association with other manifestations, routine clinical assessment should include nails examination. Knowledge of possible presentation of nail involvement after alloHSCT may be valuable for treating physician.
‘High dose’ vs. ‘medium dose’ UVA1 phototherapy in italian patients with severe atopic dermatitis
Authors: Pacifico A. , Iacovelli P. , Damiani G. , Ferraro C. , Cazzaniga S. , Conic R.R.Z. , Leone G. , Morrone A. 
Published: November 2018

AbstractBackgroundThe current evidences attest UVA1 phototherapy as effective in the treatment of severe atopic dermatitis (AD). Furthermore, in this indication, ‘medium dose’ is as effective as ‘high dose’ regimen. To date, a randomized comparison study evaluating the effectiveness as well as safety of different UVA1 protocols in different skin types in the treatment of adult patients with severe AD is still lacking.ObjectiveThe aim of the present study was to compare the safety and the efficacy of medium and high dose UVA1 either in fair or in dark skin types.MethodsTwenty‐seven adult patients with severe AD were consecutively included in a randomized, controlled, open, two arms trial Severity of AD was determined by means of SCORAD index and clinical improvement was also monitored. A total of 13 out of 27 patients were treated with high dose (130 J/cm2) UVA1 protocol while 14 out of 27 patients received medium dose (60 J/cm2) UVA1 protocol. Phototherapy was performed five times weekly up to 3 weeks. Before and after UVA1 treatment each patient was evaluated for skin pigmentation through Melanin Index (MI) quantitative evaluation.ResultsSkin status improved in all patients resulting in a reduction of SCORAD index in all groups. Our results demonstrated that among patients with darker skin types and higher MI, high dose UVA1 was significantly more effective than medium dose (P < 0.0001) while within the groups with skin type II, no significant differences between high and medium dose protocols were observed.ConclusionOur study, confirms previous observations that UVA1 phototherapy should be considered among the first approaches in the treatment of patients with severe generalized AD and also demonstrates that in darker skin types, high dose UVA1 phototherapy is more effective than medium dose in the treatment of adult patients with severe AD.