bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local estrogen formation and its regulation in endometriosis
Authors: Mori Taisuke , Ito Fumitake , Koshiba Akemi , Kataoka Hisashi , Takaoka Osamu , Okimura Hiroyuki , Khan Khaleque N. , Kitawaki Jo 
Published: June 2019

AbstractBackgroundIt has been well established that endometriosis is an estrogen‐dependent disease. Although the exact pathogenesis of the disease is still unclear, it is known to be characterized by estrogen‐dependent growth and maintenance of the ectopic endometrium and increased local estrogen production.MethodsThe authors reviewed studies on local estrogen production and estrogen activities mediated by estrogen receptors in endometriotic tissues.Main findingsAberrant expression of several enzymes in local endometriotic lesions contributed to the production and metabolism of estrogens. Aromatase was one of the key therapeutic targets for the regulation of local estrogen formation. Our findings suggest that PGC‐1a, a transcriptional coactivator‐modulating steroid hormone, regulates aromatase expression and activity. Estrogen activities mediated by different types of estrogen receptors abnormally elevated in local tissues could also be involved in the development of endometriosis. The authors demonstrated that the isoflavone aglycone, a partial agonist of the estrogen receptor, suppressed the formation of endometriotic lesions.ConclusionsLocal estrogen production and estrogen activity mediated by estrogen receptors are important potential therapeutic targets for endometriosis.
Command‐filtered fixed‐time trajectory tracking control of surface vehicles based on a disturbance observer
Authors: Gao Zhenyu , Guo Ge 
Published: June 2019

SummaryIn this paper, we investigate trajectory tracking control of surface vehicles with model parameter uncertainties and external disturbances. The disturbances due to the wind, waves, and ocean currents are combined with the model parameter uncertainties as a compound disturbance. Then, a disturbance observer (DO) is introduced to estimate the compound disturbance, which can be achieved within a finite time independent of the initial estimation error. Based on the DO and, in the context of command filtered control, a novel fixed‐time backstepping control scheme is developed, by which the vehicle can track the desired trajectory with all the states globally stabilized in a given fixed time. The effectiveness and performance of the method are demonstrated by numerical simulations.
Synthesis of Hollow Nanospherical Cuprous Oxide Supported by Nitrogen‐Doped Reduced Graphene Oxide and Its Application to Enzyme‐Free Glucose Sensing
Authors: Chen Kang , Zhang Rong , Li Yuehua , Jiang Mengxiu , Wang Wenyang , Cui Zixiang 
Published: June 2019

AbstractNitrogen‐doped reduced graphene oxide (N‐rGO) was obtained via high temperature heat treatment using ammonia as a nitrogen source. EDS and XPS tests revealed that the nitrogen atoms have been doped into the skeleton of graphene successfully. On this basis, hollow nanospherical cuprous oxide supported by N‐rGO (HNS‐Cu2O/N‐rGO) was synthesized by chemical precipitation as electrode materials for detection of glucose. TEM test showed that the hollow spherical cuprous oxide has been successfully supported on the surface of N‐rGO. In the case of electrochemical studies, the HNS‐Cu2O/N‐rGO modified glass carbon electrode presented a linear range from 4 μM to 2.37 mM for glucose detection with a sensitivity of 2488.8 μA⋅mM−1⋅cm−2, a detection limit of 2.28 μM (S/N=3) and fast amperometric response. Furthermore, the nanocomposite displayed good selectivity for glucose detection in the presence of interferences. The entire analysis demonstrates the applicability of HNS‐Cu2O/N‐rGO nanocomposite as one of the futuristic sensing material for glucose detection.
Synthesis and Antimicrobial Activity of Novel Thiazoles with Reactive Functional Groups
Authors: Grybaitė Birutė , Vaickelionienė Rita , Stasevych Maryna , Komarovska‐Porokhnyavets Olena , Kantminienė Kristina , Novikov Volodymyr , Mickevičius Vytautas 
Published: June 2019

AbstractA series of substituted thiazoles bearing different functional groups, such as carboxyethylamino, carboxyl, chloromethyl, (phenylamino)methyl, ethoxyoxoethyl, methoxyoxoethylidene, ethoxycarbonyl, (methoxy or hydrazinyl)oxopropyl, carbohydrazinyl, formyl, and ((phenyl, carbamothioyl or isonicotinoyl)hydrazono)methyl, incorporated into their structure were synthesized. The synthesized compounds were tested for their antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Mycobacterium luteum bacteria strains, and Candida tenuis and Aspergillus niger fungi. Compounds exhibiting exclusive antifungal activity against Aspergillus niger (MIC 0.9, 1.9 μg/mL) and Candida tenuis (MIC 7.8 μg/mL) have been identified among the novel thiazole derivatives.
Citric Acid/MCM‐48 Catalyzed Multicomponent Reaction: An Efficient Method for the Novel Synthesis of Quinoline Derivatives
Authors: Akpotu Samson O. , Moodley Brenda , Vamsi Boddu , Ofomaja Augustine , Maddila Suresh , Jonnalagadda Sreekantha B 
Published: June 2019

AbstractA facile, efficient and suitable green approach has been designated for the one‐pot synthesis of quinoline derivatives in the presence of citric acid doped MCM‐48 (CAMCM‐48) as a heterogeneous catalyst. The prepared material was characterized by using various techniques like P‐XRD, SEM, TEM, TGA, FTIR and structural properties was determined by BET analysis. The reaction progressed efficiently under ethanol solvent system at room temperature condition to afford the corresponding products. This protocol offers many advantages such as simple synthesis, easy work‐up, short reaction times (15 min), good stability, reusability and no chromatographic separation techniques plus excellent yields (91‐98%).
Facile Fabrication of Highly Efficient Photoelectrocatalysts MxOy@NH2‐MIL‐125(Ti) for Enhanced Hydrogen Evolution Reaction
Authors: Fiaz Muhammad , Kashif Muhammad , Majeed Saadat , Ashiq Muhammad Naeem , Farid Muhammad Asim , Athar Muhammad 
Published: June 2019

AbstractHighly efficient amine functionalized MxOy@NH2‐MIL‐125(Ti) (MxOy=MnO2, Fe2O3, Co3O4, NiO, CuO and ZnO) photoelectrocatalysts have been synthesized by using a simple and cost effective synthetic approach through in‐situ incorporation of pre‐synthesized metal oxide nanoparticles into NH2‐MIL‐125(Ti) MOF via hydrothermal method. All the synthesized samples have been characterized by Powder X‐ray Diffraction, Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, Energy Dispersive X‐ray Spectrometry, Elemental Mapping, UV‐Vis Spectroscopy and N2‐adsorption isotherm. It has been found that incorporation of nanoparticles into porous MOF decreased the band gap, reduced the electron‐hole pair recombination and enhanced the efficient absorption of visible light. Hydrogen evolution reaction is evaluated by Cyclic voltammetry and linear sweep voltammetry studies at 100 mV/s and 1 mV/s, respectively. Amongst various synthesized samples, CuO@NH2‐MIL‐125(Ti) required lowest overpotential of 146 mV to achieve −5mAcm−2 current density as compared to 226 mV for bare NH2‐MIL‐125(Ti). Moreover, MxOy@NH2‐MIL‐125(Ti) samples showed lower onset potential for hydrogen evolution reaction as compared to bare NH2‐MIL‐125(Ti). Chronoamperometric measurements of all these samples showed their stability for 600 seconds at constant applied voltage of 1.5 V.
Multi‐Responsive Supramolecular Hydrogels Derived from Gemini Surfactants for Visual Recognition of Isomerization
Authors: Zhong Jinlian , Zhong Juping , Zhong Xiang , Chen Yali , Jiang Wenting , Chen Zhixing , Liu Huijin , Jia Xinjian , Luo Xuzhong 
Published: June 2019

AbstractA new series of gemini surfactants containing azobenzene moieties with different alkyl chains (TMn, n denotes the number of carbon atom in alkyl chains) were successfully designed and synthesized. And then, their gelation abilities in water were evaluated in detail. It was found that stable supramolecular hydrogels could be formed at room temperature when n=8 (TM8), in which TM8 molecules self‐assembled into ordered bilayer aggregates via intermolecular hydrogen bonding and π‐π stacking interactions. Moreover, this kind of hydrogel exhibits excellent mechanical property and thermo‐reversibility. Interestingly, the TM8 molecule can be well‐recognized by α‐cyclodextrin (α‐CD) via host‐guest interactions. When α‐CD is added to the TM8‐H2O system, the corresponding hydrogel displays photo‐sensitive characteristics under irradiation of UV light (365 nm). As a conversion material, this multi‐responsive supramolecular hydrogel has great potentials in the smart switch field.
Enfranchising the future: Climate justice and the representation of future generations
Authors: Gonzalez‐Ricoy Inigo , Rey Felipe 
Published: June 2019

AbstractRepresenting unborn generations to more suitably include future interests in today's climate policymaking has sparked much interest in recent years. In this review we survey the main proposed instruments to achieve this effect, some of which have been attempted in polities such as Israel, Philippines, Wales, Finland, and Chile. We first review recent normative work on the idea of representing future people in climate governance: The grounds on which it has been advocated, and the main difficulties that traditional forms of representation have encountered when applied to this particular case. We then survey existing institutional means to represent generations to come. We separate out representation in courts, in parliament, and by independent bodies, and review specific instruments including climate litigation, parliamentary commissions, future representatives, youth quotas, and independent offices for future generations. We examine the particular forms whereby each of these may suitably represent future people, including audience representation, surrogate representation, and indicative representation, and discuss the main challenges they encounter in so doing.This article is categorized under:
Climate, Nature, and Ethics > Climate Change and Human Rights
Smart city big data analytics: An advanced review
Authors: Soomro Kamran , Bhutta Muhammad Nasir Mumtaz , Khan Zaheer , Tahir Muhammad A. 
Published: June 2019

AbstractWith the increasing role of ICT in enabling and supporting smart cities, the demand for big data analytics solutions is increasing. Various artificial intelligence, data mining, machine learning and statistical analysis‐based solutions have been successfully applied in thematic domains like climate science, energy management, transport, air quality management and weather pattern analysis. In this paper, we present a systematic review of the literature on smart city big data analytics. We have searched a number of different repositories using specific keywords and followed a structured data mining methodology for selecting material for the review. We have also performed a technological and thematic analysis of the shortlisted literature, identified various data mining/machine learning techniques and presented the results. Based on this analysis we also present a classification model that studies four aspects of research in this domain. These include data models, computing models, security and privacy aspects and major market drivers in the smart cities domain. Moreover, we present a gap analysis and identify future directions for research. For the thematic analysis we identified the themes smart city governance, economy, environment, transport and energy. We present the major challenges in these themes, the major research work done in the field of data analytics to address these challenges and future research directions.This article is categorized under:

Application Areas > Government and Public Sector
Fundamental Concepts of Data and Knowledge > Big Data Mining
In the quagmire of quibbles: a dialectical exploration
Authors: Krabbe Erik C. W. , van Laar Jan Albert 
Published: June 2019

AbstractCriticism may degenerate into quibbling or nitpicking. How can discussants keep quibblers under control? In the paper we investigate cases in which a battle about words replaces a discussion of the matters that are actually at issue as well as cases in which a battle about minor objections replaces a discussion of the major issues. We survey some lines of discussion dealing with these situations in profiles of dialogue.
Intelligent Hybridization of Regression Technique with Genetic Algorithm for Navigation of Humanoids in Complex Environments
Authors: Kumar Priyadarshi Biplab , Parhi Dayal R. 
Published: June 2019

SUMMARYIn the current investigation, a novel navigational controller has been designed and implemented for humanoids in cluttered environments. Here, regression analysis is hybridized with genetic algorithm (GA) for designing the controller. The obstacle distances collected in the form of sensor outputs are initially fed to the regression controller; and based on the previous training pattern data, an intermediate advancing angle (AA) is obtained as the first output. The intermediate AA obtained from the regression controller along with other inputs is again fed to the GA controller, which generates the final AA as the desired final output to avoid the obstacles present in a complex environment and reach the destination successfully. The working of the controller is tested on a V-REP simulation platform. In the current work, navigation of both single as well as multiple humanoids has been attempted. To avoid inter-collision among multiple humanoids during their navigation in a common platform, a Petri-Net model has been proposed. The simulation results are validated through a real-time experimental platform developed under laboratory conditions. The results obtained from both the simulation and experimental platforms are compared against each other and are found to be in good agreement with acceptable percentage of errors. Finally, the proposed controller is also compared with other existing navigational controller and an improvement in performance has been observed.
Food insecurity in a pre-bariatric surgery sample: prevalence, demographics and food shopping behaviour
Authors: Price Julia A , Zickgraf Hana F , Rigby Andrea 
Published: June 2019

AbstractObjective:To identify the prevalence and demographic characteristics of food insecurity in a presurgical bariatric population. To date there has been no research on food insecurity in a presurgical bariatric population.Design:Participants completed the ten-item adult food security survey module created by the US Department of Agriculture (USDA), with additional questions related to food shopping behaviours and perceived affordability of post-bariatric supplements. USDA scoring guidelines were used to classify participants as food secure, marginally food secure and food insecure.Setting:Academic medical centre bariatric surgery clinic in Central Pennsylvania, USA.Participants:Adult bariatric surgery candidates (n 174).Results:There was a prevalence of 17·8 % for food insecurity and 27·6 % for marginal food security. Food insecurity was associated with younger age, higher BMI, non-White race/ethnicity, having less than a college education, living in an urban area, receiving Medicaid/Medicare and participating in nutrition assistance programmes. Food-insecure participants endorsed food shopping behaviours that could interfere with postsurgical dietary adherence and perceived post-bariatric supplies as unaffordable or inaccessible.Conclusions:These results highlight the importance of screening bariatric surgical patients for food insecurity. Further study of this important problem within the bariatric population should address effects of food insecurity and related shopping behaviours on postsurgical outcomes and inform the development of programmes to better assist these high-risk patients.
Hydrocarbon Removal in Power Plant Plumes Shows Nitrogen Oxide Dependence of Hydroxyl Radicals
Authors: de Gouw J. A. , Parrish D. D. , Brown S. S. , Edwards P. , Gilman J. B. , Graus M. , Hanisco T. F. , Kaiser J. , Keutsch F. N. , Kim S.‐W. , Lerner B. M. , Neuman J. A. , Nowak J. B. , Pollack I. B. , Roberts J. M. , Ryerson T. B. , Veres P. R. , Warneke C. , Wolfe G. M. 
Published: June 2019

AbstractDuring an airborne study in the Southeast United States, measured mixing ratios of biogenic hydrocarbons were systematically lower in air masses containing enhanced nitrogen oxides from power plants, which we attribute to increased concentrations of hydroxyl (OH) radicals within the power plant plumes. Plume transects at successively further downwind distances provide a decreasing gradient of nitrogen oxides (NOx) concentrations, which together with the implied loss rates of isoprene, constrains the OH dependence on NOx. We find that OH concentrations were highest at nitrogen dioxide concentrations near 1–2 ppbv and decreased at higher and at lower concentrations. These findings agree with the dependence of OH on NOx concentrations expected from known chemical reactions but are not consistent with some studies reporting direct OH measurements higher than expected in regions of the atmosphere with low NOx (NO < 0.08 and NO2 < 0.46 ppbv) and high biogenic hydrocarbon emissions.
Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment
Authors: Dumont Adélie , de Rosny Charlotte , Kieu Trinh-Le-Vi , Perrey Sabrina , Berger Hélène , Fluckiger Aurélie , Muller Tania , Pais de Barros Jean-Paul , Pichon Laurent , Hichami Aziz , Thomas Charles , Rébé Cédric , Ghiringhelli François , Rialland Mickaël 
Published: June 2019

AbstractLimitation of 5-fluorouracil (5-FU) anticancer efficacy is due to IL-1β secretion by myeloid-derived suppressor cells (MDSC), according to a previous pre-clinical report. Release of mature IL-1β is a consequence of 5-FU-mediated NLRP3 activation and subsequent caspase-1 activity in MDSC. IL-1β sustains tumor growth recovery in 5-FU-treated mice. Docosahexaenoic acid (DHA) belongs to omega-3 fatty acid family and harbors both anticancer and anti-inflammatory properties, which could improve 5-FU chemotherapy. Here, we demonstrate that DHA inhibits 5-FU-induced IL-1β secretion and caspase-1 activity in a MDSC cell line (MSC-2). Accordingly, we showed that DHA-enriched diet reduces circulating IL-1β concentration and tumor recurrence in 5-FU-treated tumor-bearing mice. Treatment with 5-FU led to JNK activation through ROS production in MDSC. JNK inhibitor SP600125 as well as DHA-mediated JNK inactivation decreased IL-1β secretion. The repression of 5-FU-induced caspase-1 activity by DHA supplementation is partially due to β-arrestin-2-dependent inhibition of NLRP3 inflammasome activity but was independent of JNK pathway. Interestingly, we showed that DHA, through β-arrestin-2-mediated inhibition of JNK pathway, reduces V5-tagged mature IL-1β release induced by 5-FU, in MDSC stably overexpressing a V5-tagged mature IL-1β form. Finally, we found a negative correlation between DHA content in plasma and the induction of caspase-1 activity in HLA-DR− CD33+ CD15+ MDSC of patients treated with 5-FU-based chemotherapy, strongly suggesting that our data are clinical relevant. Together, these data provide new insights on the regulation of IL-1β secretion by DHA and on its potential benefit in 5-FU-based chemotherapy.
CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI
Authors: Hu Wen-Feng , Krieger Kimiko L. , Lagundžin Dragana , Li Xueli , Cheung Ronald S. , Taniguchi Toshiyasu , Johnson Keith R. , Bessho Tadayoshi , Monteiro Alvaro N. A. , Woods Nicholas T. 
Published: June 2019

AbstractBRCA1 C-terminal domains are found in a specialized group of 23 proteins that function in the DNA damage response to protect genomic integrity. C-terminal domain phosphatase 1 (CTDP1) is the only phosphatase with a BRCA1 C-terminal domain in the human proteome, yet direct participation in the DNA damage response has not been reported. Examination of the CTDP1 BRCA1 C-terminal domain-specific protein interaction network revealed 103 high confidence interactions enriched in DNA damage response proteins, including FANCA and FANCI that are central to the Fanconi anemia DNA repair pathway necessary for the resolution of DNA interstrand crosslink damage. CTDP1 expression promotes DNA damage-induced FANCA and FANCD2 foci formation and enhances homologous recombination repair efficiency. CTDP1 was found to regulate multiple aspects of FANCI activity, including chromatin localization, interaction with γ-H2AX, and SQ motif phosphorylations. Knockdown of CTDP1 increases MCF-10A sensitivity to DNA interstrand crosslinks and double-strand breaks, but not ultraviolet radiation. In addition, CTDP1 knockdown impairs in vitro and in vivo growth of breast cancer cell lines. These results elucidate the molecular functions of CTDP1 in Fanconi anemia interstrand crosslink repair and identify this protein as a potential target for breast cancer therapy.
A tectonically driven Ediacaran oxygenation event
Authors: Williams Joshua J. , Mills Benjamin J. W. , Lenton Timothy M. 
Published: June 2019

AbstractThe diversification of complex animal life during the Cambrian Period (541–485.4 Ma) is thought to have been contingent on an oxygenation event sometime during ~850 to 541 Ma in the Neoproterozoic Era. Whilst abundant geochemical evidence indicates repeated intervals of ocean oxygenation during this time, the timing and magnitude of any changes in atmospheric pO2 remain uncertain. Recent work indicates a large increase in the tectonic CO2 degassing rate between the Neoproterozoic and Paleozoic Eras. We use a biogeochemical model to show that this increase in the total carbon and sulphur throughput of the Earth system increased the rate of organic carbon and pyrite sulphur burial and hence atmospheric pO2. Modelled atmospheric pO2 increases by ~50% during the Ediacaran Period (635–541 Ma), reaching ~0.25 of the present atmospheric level (PAL), broadly consistent with the estimated pO2 > 0.1–0.25 PAL requirement of large, mobile and predatory animals during the Cambrian explosion.
A bionic stretchable nanogenerator for underwater sensing and energy harvesting
Authors: Zou Yang , Tan Puchuan , Shi Bojing , Ouyang Han , Jiang Dongjie , Liu Zhuo , Li Hu , Yu Min , Wang Chan , Qu Xuecheng , Zhao Luming , Fan Yubo , Wang Zhong Lin , Li Zhou 
Published: June 2019

AbstractSoft wearable electronics for underwater applications are of interest, but depend on the development of a waterproof, long-term sustainable power source. In this work, we report a bionic stretchable nanogenerator for underwater energy harvesting that mimics the structure of ion channels on the cytomembrane of electrocyte in an electric eel. Combining the effects of triboelectrification caused by flowing liquid and principles of electrostatic induction, the bionic stretchable nanogenerator can harvest mechanical energy from human motion underwater and output an open-circuit voltage over 10 V. Underwater applications of a bionic stretchable nanogenerator have also been demonstrated, such as human body multi-position motion monitoring and an undersea rescue system. The advantages of excellent flexibility, stretchability, outstanding tensile fatigue resistance (over 50,000 times) and underwater performance make the bionic stretchable nanogenerator a promising sustainable power source for the soft wearable electronics used underwater.