bluuebunny/crossref_metadata_2025_split huggingface dataset:
The green city citizen: Exploring the ambiguities of sustainable lifestyles in Copenhagen
Authors: Winter Amanda K. 
Published: November 2018

AbstractSustainable lifestyles research to date reveals a need for empirical insight to how it is defined in practice within the context of societal change. This article attends to this gap by demonstrating how sustainable lifestyles are understood in one of the world's “greenest” cities: Copenhagen (DK). On the basis of ethnographic field research with local policy‐makers and sustainability‐oriented community groups, I found that a dominant theme reflects Copenhagen's green city policy goals, as it envisions a techno‐moral, energy‐efficient citizen. Three contradictions were evident in this imaginary: privilege (class), suburbanites (scale), and disincentivizing (measurement). I give examples of how this green city citizen imaginary is inserted in policy, which demonstrates a disjuncture between how sustainable lifestyles are understood in practice and theory. This study empirically contributes to the ambiguous concept of sustainable lifestyles, while shedding light on potential social tensions of technocentric green city policy.
Effectiveness of the European Society of Cardiology/Heart Failure Association website ‘heartfailurematters.org’ and an e‐health adjusted care pathway in patients with stable heart failure: results of the ‘e‐Vita HF’ randomized controlled trial
Authors: Wagenaar Kim P. , Broekhuizen Berna D.L. , Jaarsma Tiny , Kok Ilse , Mosterd Arend , Willems Frank F. , Linssen Gerard C.M. , Agema Willem R.P. , Anneveldt Sander , Lucas Carolien M.H.B. , Mannaerts Herman F.J. , Wajon Elly M.C.J. , Dickstein Kenneth , Cramer Maarten J. , Landman Marcel A.J. , Hoes Arno W. , Rutten Frans H. 
Published: November 2018

BackgroundEfficient incorporation of e‐health in patients with heart failure (HF) may enhance health care efficiency and patient empowerment. We aimed to assess the effect on self‐care of (i) the European Society of Cardiology/Heart Failure Association website ‘heartfailurematters.org’ on top of usual care, and (ii) an e‐health adjusted care pathway leaving out ‘in person’ routine HF nurse consultations in stable HF patients.Methods and resultsIn a three‐group parallel‐randomized trial in stable HF patients from nine Dutch outpatient clinics, we compared two interventions (
heartfailurematters.org website and an e‐health adjusted care pathway) to usual care. The primary outcome was self‐care measured with the European Heart Failure Self‐care Behaviour Scale. Secondary outcomes were health status, mortality, and hospitalizations. In total, 450 patients were included. The mean age was 66.8 ± 11.0 years, 74.2% were male, and 78.8% classified themselves as New York Heart Association I or II at baseline. After 3 months of follow‐up, the mean score on the self‐care scale was significantly higher in the groups using the website and the adjusted care pathway compared to usual care (73.5 vs. 70.8, 95% confidence interval 0.6–6.2; and 78.2 vs. 70.8, 95% confidence interval 3.8– 9.4, respectively). The effect attenuated, until no differences after 1 year between the groups. Quality of life showed a similar pattern. Other secondary outcomes did not clearly differ between the groups.ConclusionsBoth the heartfailurematters.org website and an e‐health adjusted care pathway improved self‐care in HF patients on the short term, but not on the long term. Continuous updating of e‐health facilities could be helpful to sustain effects.Clinical Trial registration: ClinicalTrials.gov ID NCT01755988.
CD300 receptor family in viral infections
Authors: Vitallé Joana , Terrén Iñigo , Orrantia Ane , Zenarruzabeitia Olatz , Borrego Francisco 
Published: November 2018

AbstractThe CD300 molecules constitute an evolutionarily significant family of receptors that are expressed on myeloid and lymphoid cells, but also on other cell types, such as tuft cells. Many of the CD300 receptors have been shown to recognize lipids, e.g. phosphatidylserine and phosphatidylethanolamine. Over the past couple of years, accumulating evidence has shown that this family of receptors is involved in the pathogenesis of many diseases. Specifically, CD300 molecules participate in the mechanisms that viruses employ to develop immune evasion strategies and to infect host cells. The participation of CD300 molecules in viral infection includes both lipid dependent and independent mechanisms, as for example in infections with dengue virus (DENV) and murine norovirus (MNV), respectively. CD300 receptors are also involved in viral escape mechanisms, for instance inhibiting NK cell‐mediated cytotoxicity against infected cells. Moreover, it is becoming increasingly recognized that the expression of CD300 receptors is altered during viral diseases. Here, we review the involvement of human and murine CD300 molecules in viral binding and entry and in cellular responses to viruses, which highlights the potential of CD300 molecules in the search of new biomarkers for various stages of infection and therapeutic targets for the treatment of viral infections.
Early Cretaceous arc granitoids from the central Lhasa subterrane: Production of the northward subduction of Yarlung Zangbo Neo‐Tethyan Ocean?
Authors: Zheng Hao , Huang Qiang‐Tai , Cai Zhou‐Rong , Zhang Kai‐Jun , Liu Hui‐Chuan , Cheng Chen , Lu Li‐Juang , Yang Peng , Yu Sheng‐rui 
Published: November 2018

There is ongoing debate as to the genesis of the Lhasa Terrane during the Mesozoic (northward subduction of Yanglu‐Zangbo Tethyan Ocean [YZTO] or southward subduction of Bangong–Nujiang Tethyan Ocean [BNTO]). In this paper, we report a dataset of geochronology, geochemistry, and Sr–Nd–Hf isotopes for the Azhale granitoids in order to elucidate the dominant geodynamic processes of the central subterrane. These rocks are dated at 142.2 ± 1.0 and 136.6 ± 0.6 Ma by zircon LA–ICP–MS method, indicating that these rocks were contemporaneous. In situ zircon Hf isotopic analyses yielded εHf(t) values of −4.2 to −0.1. Geochemically, these samples mostly belong to calc‐alkaline series and show strong enrichments in large‐ion lithophile elements (LILE;e.g., Rb, Ba, and Th) and depletions in high‐field‐strength elements (HFSE;e.g., Nb and Ta), indicating the Azhale granitoids are typically I‐type granite. In terms of isotopic composition, these rocks also have low εNd(t) values (−6.51 to −6.80) and high initial 87Sr/86Sr ratios (0.7078 to 0.7084) relative to melts derived from partial melting of ancient mafic lower crust. We considered that these rocks should be interpreted to have resulted from melting, assimilation, storage, and homogenization (MASH process) above subduction zones. In conclusion, combined with the published and our new data, we argued for the petrogenesis of Early Cretaceous arc‐related granitoids were due to the YZTO lithosphere subducted northward beneath the Lhasa Terrane.
Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development
Authors: Tozaki‐Saitoh Hidetoshi , Masuda Junya , Kawada Ryu , Kojima Chinami , Yoneda Sosuke , Masuda Takahiro , Inoue Kazuhide , Tsuda Makoto 
Published: November 2018

AbstractMicroglia, which are pathological effectors and amplifiers in the central nervous system, undergo various forms of activation. A well‐studied microglial‐induced pathological paradigm, spinal microglial activation following peripheral nerve injury (PNI), is a key event for the development of neuropathic pain but the transcription factors contributing to microglial activation are less understood. Herein, we demonstrate that MafB, a dominant transcriptional regulator of mature microglia, is involved in the pathology of a mouse model of neuropathic pain. PNI caused a rapid and marked increase of MafB expression selectively in spinal microglia but not in neurons. We also found that the microRNA mir‐152 in the spinal cord which targets MafB expression decreased after PNI, and intrathecal administration of mir‐152 mimic suppressed the development of neuropathic pain. Reduced MafB expression using heterozygous Mafb deficient mice and by intrathecal administration of siRNA alleviated the development of PNI‐induced mechanical hypersensitivity. Furthermore, we found that intrathecal transfer of Mafb deficient microglia did not induce mechanical hypersensitivity and that conditional Mafb knockout mice did not develop neuropathic pain after PNI. We propose that MafB is a key mediator of the PNI‐induced phenotypic alteration of spinal microglia and neuropathic pain development.
Bilateral vocal cord paralysis in a patient with myasthenia gravis
Authors: Zhou Guojun , Wu Min , Xia WeiSheng 
Published: November 2018

SummaryA 65‐yr old female developed bilateral vocal cord paralysis following thoracoscopy and pulmonary resection. Surgery, which was performed using a thoracoscope and with lung separation techniques, proceeded without complication. She was transferred to the ICU after surgery and extubated on the third postoperative day when she complained of persistent severe hoarseness and dysphasia. She was subsequently diagnosed with myasthenia gravis and bilateral vocal cord paralysis due to bulbar muscle fatigue. Treatment was with prednisolone and pyridostigmine bromide. Oesophageal function recovered on the twenty‐second day and she regained her normal voice four weeks later. We describe this rare cause of postoperative hoarseness and discuss the causes.
Fabrication of Nanofibrous PVA/Alginate‐Sulfate Substrates for Growth Factor Delivery
Authors: Mohammadi Sajjad , Ramakrishna Seeram , Laurent Sophie , Shokrgozar Mohammad Ali , Semnani Dariush , Sadeghi Davoud , Bonakdar Shahin , Akbari Mohsen 
Published: November 2018

AbstractProviding affinity sites on alginate (ALG) matrix enables specific binding of growth factors to the polymer backbone and allows their release in a controlled fashion. In this study, we used a blend of alginate sulfate (ALG‐S) and polyvinyl alcohol (PVA) to fabricate electrospun scaffolds capable of delivering a heparin‐like growth factor, transforming growth factor‐beta1 (TGF‐β1). The alginate was sulfated with different degrees of sulfation (DS, from 0.8, 3.4 to 12.4%) by a simple process. The success of sulfation was determined by Fourier‐transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (NMR), elemental analysis, ultraviolet (UV) spectroscopy and staining with dimethylmethylene blue. The physical‐mechanical properties of nanofibrous mats were characterized by scanning electron microscopy (SEM), FTIR, energy‐dispersive X‐ray spectroscopy (EDX), tensile strength and mass loss analysis. Additionally, the release kinetics of transforming growth factor‐β1 (TGF‐β1) from PVA/ALG‐S and PVA/ALG scaffolds were compared. The results showed that the binding and entrapment of TGF‐β1 to the nanofibrous scaffolds are improved by the addition of sulfate group to alginate. In conclusion, our results support that nanofibrous scaffold based on PVA/ALG‐S can deliver growth factors in tissue engineering application. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 403–413, 2019.
Mechanical and biological evaluation of a hydroxyapatite‐reinforced scaffold for bone regeneration
Authors: Patel Pushpendra P. , Buckley Christian , Taylor Brittany L. , Sahyoun Christine C. , Patel Samarth D. , Mont Ashley J. , Mai Linh , Patel Swati , Freeman Joseph W. 
Published: November 2018

AbstractWith over 500,000 bone grafting procedures performed annually in the United States, the advancement of bone regeneration technology is at the forefront of medical research. Many tissue‐engineered approaches have been explored to develop a viable synthetic bone graft substitute, but a major challenge is achieving a load‐bearing graft that appropriately mimics the mechanical properties of native bone. In this study, sintered hydroxyapatite (HAp) was used to structurally reinforce a scaffold and yield mechanical properties comparable to native bone. HAp was packed into a cylindrical framework and processed under varying conditions to maximize its mechanical properties. The resulting HAp columns were further tested in a 6‐week degradation study to determine their physical and mechanical response. The cellular response of sintered HAp was determined using a murine preosteoblast cell line, MC3T3‐E1. Cell viability and morphology were studied over a one‐week period and MC3T3‐E1 differentiation was determined by measuring the alkaline phosphatase levels. Finite element analysis was used to determine the columns' geometric configuration and arrangement within our previously developed composite bone scaffold. It was determined that incorporating four cylindrical HAp columns, fabricated under 44 MPa of pressure and sintered at 1200°C for 5 hr, led to load‐bearing properties that match the yield strength of native whole bone. These preliminary results indicate that the incorporation of a mechanically enhanced HAp structural support system is a promising step toward developing one of the first load‐bearing bone scaffolds that can also support cell proliferation and osteogenic differentiation. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 732–741, 2019.
Assessment of rapid diagnostic tests and fourth‐generation Enzyme‐Linked Immunosorbent Assays in the screening of Human Immunodeficiency and Hepatitis B virus infections among first‐time blood donors in Libreville (Gabon)
Authors: Eko Mba Jean Marie , Bisseye Cyrille , Mombo Landry Erik , Ntsame Ndong Jophrette Mireille , Mbina Ekayeng Schella Carlaye , Bengone Calixte , M’batchi Bertrand , Nagalo Bolni Marius 
Published: November 2018

AbstractBackgroundBlood transfusion is a pathway for the transmission of blood‐borne pathogens such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV) from donors to recipients in most countries in sub‐Saharan Africa, including Gabon. The study aimed to compare the performance of four rapid diagnostic tests (RDTs: Alere DETERMINE, BIOSYNEX Exacto Pro HIV, MEDIFF HIV 1&2, and BIOSYNEX IMMUNOQUICK HBsAg) with results of 4th‐generation immunoenzymatic assays COBAS 6000 e601 and EVOLIS BioRad for the detection of HIV and hepatitis B surface antigen (HBsAg) in blood donors in Libreville, Gabon.MethodsReactive and nonreactive blood samples for HIV and HBsAg were selected using fourth‐generation ELISA COBAS 6000 e601 and EVOLIS BioRad. The sensitivities of RDTs were calculated using Epi Info version 6.04dfr (CDC, Atlanta, USA).ResultsSensitivities for the detection of HIV in blood donors were 90.9% for Alere DETERMINE, 81.8% for BIOSYNEX Exacto Pro HIV, and 81.8% for MEDIFF HIV 1&2 Serum/sang Total Cassette compared with COBAS 6000 e601. The sensitivity of Alere DETERMINE compared to the semi‐automated ELISA Bio‐Rad for HIV detection was 65.6%. The sensitivity of BIOSYNEX IMMUNOQUICK HBsAg compared to ELISA tests for the detection of HBsAg was 78.0%. The specificity of all RDTs for the detection of HIV and HBsAg was 100%.ConclusionAlere DETERMINE HIV‐1/2, MEDIFF HIV 1&2 Serum/sang Total Cassette, BIOSYNEX Exacto Pro HIV, and BIOSYNEX IMMUNOQUICK HBsAg are not recommended for determining whether donors qualify to donate blood because of their low sensitivity for the detection of HIV antibodies and HBsAg in blood donors in Gabon.
Association of the study between LncRNA‐H19 gene polymorphisms with the risk of breast cancer
Authors: Abdollahzadeh Safa , Ghorbian Saeid 
Published: November 2018

AbstractBackgroundThe H19 is a maternally expressed imprinted gene transcribing a long noncoding RNA (lncRNA), which has previously been reported to be involved in tumorigenesis and cancer progression. The aim of this study was to evaluate the associations between two lncRNA‐H19 (rs3741219 T>C and rs217727 C>T) gene polymorphisms with the risk of breast cancer (BC).MethodsIn a case‐control investigation, we evaluated 150 BC patients and 100 cancer‐free subjects in East Azerbaijan Province of Iran. To assess two gene polymorphisms, the polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) method was used.ResultsThe genotype frequencies of two lncRNA‐H19 (rs217727 C>T and rs3741219 T>C) gene polymorphisms TT + TC/CC and CC + CT/TT have not shown a statistically significant association with the risk of BC (P = 0.065; OR = 0.967; 95% CI, 0.938‐0.996) and (P = 0.510; OR = 1.583; 95% CI, 0.399‐6.726), respectively. In addition, our findings revealed a significant differences in allele frequencies in lncRNA‐H19 rs217727 C>T polymorphism between groups (P = 0.033; OR = 1.985; 95% CI, 1.048‐3.761).ConclusionOur findings suggested that rs217727 C>T polymorphism may be involved in the pathogenesis of BC, whereas rs3741219 T>C variation may not be involved in the genetic background of BC in Iranian.
Hepatocellular carcinoma in otherwise sonographically normal liver
Authors: Naganuma Hiroko , Ishida Hideaki , Ogawa Masahiro , Sato Tutomu , Sageshima Masato , Suzuki Katunori , Ohyama Yoko 
Published: November 2018

AbstractPurposeHepatocellular carcinoma (HCC) on normal liver is very rare. The goal of this study was to determine the clinical manifestations and the role of ultrasonography (US) in the diagnosis of HCC arising in normal liver.MethodsThe clinical data and US findings in 12 cases of surgically resected HCC in normal liver were retrospectively analyzed.ResultsThe patients were asymptomatic, had no hepatocarcinogenic factor, and hepatic function tests were almost normal in most cases. HCCs were large, encapsulated, and solitary, and there were predominantly well‐differentiated or moderately differentiated in most cases. US showed a hypoechoic rim and lateral shadowing, suggestive of peritumoral capsule formation, and on contrast‐enhanced US (CEUS), the tumor was hyperenhanced in arterial phase and washed out in postvascular phase, revealing typical HCC findings.ConclusionsUS raises suspicion of HCC by showing lateral shadowing on grayscale ultrasound and hypervascularity on CEUS of the lesion.
Synthesis of Novel Thiazolidin‐4‐ones and Thiazinan‐4‐ones Analogous to Rosiglitazone
Authors: das Neves Adriana M. , Campos José C. , Gouvêa Daniela P. , Berwaldt Gabriele A. , Goulart Taís B. , Avila Cinara T. , Machado Pablo , Zimmer Geórgia C. , Cunico Wilson 
Published: November 2018

This work reports the synthesis of thiazolidin‐4‐ones and thiazinan‐4‐ones analogous to rosiglitazone, a potent antidiabetic drug. The desired compounds were synthesized with moderate to good yields by one‐pot reactions between different primary amines, mercaptoacetic or mercaptopropionic acids, and the 4‐(2‐(methyl(pyridin‐2‐yl)amino)ethoxy)benzaldehyde. The cyclocondensation reactions were carried out for 20 h, and all the products were characterized by 1H and 13C nuclear magnetic resonance spectroscopy, mass spectrometry, and one example by X‐ray diffraction.
Cost comparison of treatment for oropharyngeal carcinoma
Authors: Tam Kenric , Orosco Ryan K. , Dimitrios Colevas A. , Bedi Nikita , Starmer Heather M. , Beadle Beth M. , Holsinger F. Christopher 
Published: November 2018

Objectives/HypothesisBased on current guidelines, surgical and nonsurgical therapies are viable frontline treatment for patients with locoregional oropharyngeal carcinoma (OPC). We sought to compare financial parameters between chemoradiation and transoral robotic surgery (TORS) in this patient population.Study DesignCase‐control study.MethodsIn this study we identified patients with selected American Joint Committee on Cancer 7th Edition stage II to IVa OPC treated with TORS between January 2013 and December 2014. Fifteen patients who underwent TORS were stage matched with 15 patients treated with chemoradiation. Total charges and cost data for each patient were analyzed at 4‐month and 1‐year time points; functional and oncologic outcomes were assessed.ResultsThere were no significant differences in functional and oncologic outcomes. Patients undergoing TORS had a longer inpatient hospital stay, and most required a nasogastric tube for an average of 3.5 days. There were no local or regional recurrences. Across all time points, the TORS group had lower charges and costs compared to the chemoradiation group, with 14% lower costs at 1 year. In the chemoradiation group, nearly two‐thirds of costs came from radiation therapy and pharmacy expenses. Chemotherapy accounted for most pharmacy costs. The costs of operating the surgical robot accounted for a about half of surgical costs.ConclusionsSelected patients with stage II to IVa oropharyngeal carcinoma treated with TORS may incur lower costs than those treated nonsurgically. With rising healthcare spending, the financial impact of treatment might be considered for those patients eligible for treatment regimens with comparable functional and oncologic outcomes.Level of Evidence3bLaryngoscope, 129:1604–1609, 2019
A Thermally Robust La3Si6N11:Ce‐in‐Glass Film for High‐Brightness Blue‐Laser‐Driven Solid State Lighting
Authors: You Shihai , Li Shuxing , Zheng Peng , Zhou Tianliang , Wang Le , Liu Lihong , Horisaki Naoto , Xu Fangfang , Xie Rong‐Jun 
Published: November 2018

AbstractColor converter is a key luminescent material in the laser‐driven solid state lighting, which must bear high‐density excitation and serious thermal attack from the incident laser. Here, a thermally robust yellow‐emitting La3Si6N11:Ce‐in‐glass (LSN:Ce‐PiG) film for laser lighting is reported by co‐firing the LSN:Ce and glass powders on a thermally conductive sapphire substrate. No detectable interfacial reaction occurs between the LSN:Ce particle and glass matrix, enabling the film to fully inherit the original thermal robustness and high quantum efficiency. The optical performance of LSN:Ce‐PiG‐converted white laser light has been effectively optimized by changing the phosphor‐to‐glass (PtG) ratio and the film thickness. The highest light conversion efficiency is respectively achieved at PtG = 2:3 and the thickness of 70 µm, and the saturation threshold is found to decrease with either a higher PtG ratio or a thicker film. The optimized LSN:Ce‐PiG film (P2G3‐50) can withstand a maximum laser power density of 12.91 W mm−2 and produce a cool white light with a high luminous flux of 1076 lm (luminance of 773 Mcd m−2), a luminous efficiency of 166.05 lm W−1, a color rendering index of 70. These results make the LSN:Ce‐PiG film a considerably promising color converter for laser lighting.
Nanofibers for Biomedical and Healthcare Applications
Authors: Rasouli Rahimeh , Barhoum Ahmed , Bechelany Mikhael , Dufresne Alain 
Published: November 2018

AbstractUnique features of nanofibers provide enormous potential in the field of biomedical and healthcare applications. Many studies have proven the extreme potential of nanofibers in front of current challenges in the medical and healthcare field. This review highlights the nanofiber technologies, unique properties, fabrication techniques (i.e., physical, chemical, and biological methods), and emerging applications in biomedical and healthcare fields. It summarizes the recent researches on nanofibers for drug delivery systems and controlled drug release, tissue‐engineered scaffolds, dressings for wound healing, biosensors, biomedical devices, medical implants, skin care, as well as air, water, and blood purification systems. Attention is given to different types of fibers (e.g., mesoporous, hollow, core‐shell nanofibers) fabricated from various materials and their potential biomedical applications.