bluuebunny/crossref_metadata_2025_split huggingface dataset:
УПРАВЛІННЯ ІННОВАЦІЙНОЮ АКТИВНІСТЮ ПІДПРИЄМСТВ: ОСНОВНІ ХАРАКТЕРИСТИКИ ТА МЕХАНІЗМ
Authors: ЧЕРНЯЄВА Анна , МЕТЛА В'ячеслав 
Published: November 2024

Сучасні теоретичні та прикладні дослідження, що спрямовані на аналіз актуальних проблем управління інноваційною активністю українського бізнесу орієнтовані, переважно, на розкриття його галузевих аспектів і особливостей.
Підвищення інноваційної активності вітчизняних підприємств є важливим фактором досягнення цілей розвитку національної економіки у сучасний період, її післявоєнного відновлення та зростання у перспективі.
Розкриття механізму управління інноваційною активністю підприємств на основі обґрунтування її сутнісних характеристик як процесу реалізації інноваційної функції бізнесу.
Інноваційність – це сутнісна ознака бізнесу, що розкриває його спрямованість на впровадження нових ідей, технологій, продукції (послуг), пошуки нових ринків, сфер та напрямів діяльності та є базовою умовою досягнення високого рівня його конкурентоспроможності та ефективності. Інноваційність бізнесу є потенційною, як здатність до інноваційної діяльності у різних формах, і реалізованою, якщо його суб’єкти є інноваційно активними. Отже, ступень реалізації потенціалу інноваційності бізнесу залежить від інноваційної активності його організаційних одиниць – підприємств, що обумовлює необхідність формування та впровадження ефективної системи управління інноваційною активністю, завданням якого є трансформація потенціалу інноваційності у реальні інноваційні проєкти, програми й заходи.
Інноваційна активність підприємства є процесом реалізації інноваційної функції бізнесу, що визначає загальну спрямованість господарської системи на забезпечення розвитку бізнесу на основі інновацій.
A systematic review on work-life balance among IT professionals in India
Authors: Babu V. Hari , Sahayam D. Binu 
Published: November 2024

Work-life balance (WLB) entails establishing a harmonic equilibrium between one's professional and personal life. Time and energy management is the conscious practice of balancing work and personal responsibilities while prioritizing self-care and overall well-being. The IT sector has experienced substantial growth and has a prominent position in the nation's economy. The WLB has been prevalent in IT professionals over the years. This paper summarizes the recent status of research by emphasizing important discoveries from the body of extant literature and identifying significant remaining gaps using the PRISMA model. Using the databases PubMed, Google Scholar, Web of Science, Emerald, and Sage, this systematic review aims to analyze all the research conducted between 2011 and 2023 on work-life balance among Indian IT employees. This review finds various factors affecting WLB in IT employees including organizational policies, gender-specific issues, technostress, burnout, social support, and flexible work options. The findings show that supportive management, psychological freedom, and established flexible work practices can improve WLB and employee happiness. However, major gaps remain, especially in the long-term effect of mixed work settings and the interplay of socio-demographic factors with WLB. Future studies should focus on longitudinal studies, mixed-method approaches, and the success of focused interventions like psychological capital building are analyzed. Thus, addressing these gaps can provide a complete understanding of WLB among IT employees in India by informing better organizational practices and policies to create a healthy and productive workforce in the IT sectors.
Optimization of a dual-energy imaging Kinestatic Charge Detector	for chest radiography
Authors: Schmithorst Vincent J. , Endorf Robert J. , Kulatunga Sunil , Spelic David C. , DiBianca Frank A. , Rodriguez Carlos , Zeman Herbert D. , Zhu Zeping , Giakos George C. 
Published: November 2024

The Kinestatic Charge Detector (KCD) technique of projection radiography shows promise when used for dual-energy imaging, which may be performed either by taking two separate exposures at different kVp settings (the dual-kVp method) or by taking a single exposure with the KCD segmented into a front and back region (the split-detector method), as the higher energy photons will be preferentially absorbed in the back region. Using computer simulations, we have optimized the dual-energy performance of a segmented KCD using the split-detector method for chest radiography. Theoretical optimization of imaging parameters and determination of contrast resolution were performed by minimizing pixel variances of the basis materials. The expected contrast resolution of the aluminum and plexiglas basis material images was found to be acceptable for purposes of clinical diagnosis. A detector medium of krypton produced better results than xenon at the same density, and the optimal kVp setting was in the range of 120–150 kVp. Preliminary dual-energy images were taken with a small field-of-view split-detector imaging KCD system. The experimentally obtained aluminum and plexiglas basis material pixel variances agree with the theoretical results.
Fast finite Hilbert transform via DE quadrature scheme
Authors: Ji Changguo , Cui Yidong , Cao Wentian , Bao Shanglian 
Published: November 2024

Purpose: The finite Hilbert transform (FHT) or inverse finite Hilbert transform (IFHT) is recently found to have some important applications in computerized tomography (CT) arena [1-6], where they are used to filter the derivatives of back-projected data in the chord-line based CT reconstruction algorithms. In this paper, we implemented, improved and validated a fast numerical solution to the FHT via a double exponential (DE) integration scheme. A same strategy can be used to compute IFHT. Methods: To overcome the underflow of floating-point numbers, we first determined the range of variable transformation from the minimum positive value of single or double precision floating point number, the integration step can be further determined by the range of variable transformation and the integration level. Two functions with their known analytical FHTs are used to validate the implementation of the FHT via DE scheme. The surface map and 2D contour of the FHT transformation error with respect to integration level and the range of the variable transformation are used to numerically determine the optimal numbers for a fast FHT. Results: Given a specific precision, the lowest integration level and the optimal range of variable transformation, which are used to transform a signal with a certain degree of fluctuation, can be numerically determined by the surface map and 2D contour of the standard deviation of transformation error. These two numbers can then be taken to efficiently compute the FHT for other signals with the same or less degree of fluctuation. Conclusions: The FHT via DE scheme and the numerical method to determine the integration level and the range of transformation can be used for fast FHT in certain applications, such as data filtering in chord-line based CT reconstruction algorithms.
Accurate 3D data stitching in circular cone-beam micro-CT
Authors: Ji Changguo 
Published: November 2024

Purpose: In circular cone-beam microcomputed tomography (micro-CT), it is likely that the length of the Field of View (FOV) of a single acquisition is shorter than the total length of the object to be imaged, such as a rat in the case of preclinical application of micro-CT. This leads to multiple acquisitions using different bed positions with bed translations in between, which can be automated using a motorized bed stage. However, subtle mechanical inaccuracies can cause undesired effects when the reconstructed volumes of the different acquisitions are combined into one larger volume. In this paper, we develop an automated method for accurately stitching 3D computed tomography (CT) data using an image registration scheme, and validate this technique in a circular cone-beam micro-CT scanner. Methods: The approach is based on precalculated spatial transformation matrices acquired by a calibration phantom with point markers at stitching positions. The spatial transformation between two adjacent subvolumes was calculated only once with a rigid-body matching algorithm. Once all transformation matrices are obtained, all subsequent reconstructed subvolumes imaged at these fixed positions can be stitched accurately, and efficiently using these precalculated matrices. Results: We applied this method to real object/animal imaging in circular cone-beam micro-CT and compared the result with that obtained by stitching method calculated only by translation distances and CT voxel size. Both stitching errors calculated using point markers and stitched volumes of rigid object (a syringe) and small animal (a rat) illustrated the success of our proposed approach. Conclusions: Preliminary experimental results demonstrate that "3D data stitching" using an image registration scheme provides a good solution to the voxel mismatch caused by limited FOV length in circular cone-beam micro-CT. This method can be extended to other tomography techniques which need to acquire data at fixed scanning positions.
A treatment planning comparison between proton beam therapy and	intensity-modulated x-ray therapy for recurrent nasopharyngeal carcinoma
Authors: Liu Su-Wen , Li Jia-Min , Chang Joe-Yujiao , Yu Jin-Ming , Chen Qing , Jiang Qian-An , Mu Xiang-Kui , Zhao Mei-Hong , Tian Ying , Wei Qing-Long 
Published: November 2024

Background and purpose: A comparative treatment planning study was undertaken between proton beam therapy (PBT) and intensity-modulated x-ray therapy (IMXT) for patients with recurrent nasopharyngeal carcinoma (NPC), to assess the potential benefits and limitations of the two treatment modalities. Materials and methods: We retrospectively analyzed seven patients with recurrent NPC treated at our proton center with PBT from 2004 to 2007. Eclipse proton treatment planning system and Eclipse inverse treatment planning system for IMXT were employed. For each patient, the IMXT plan was optimized with nine evenly spaced coplanar fields. Three coplanar beams and passive scattering mode were used for PBT. The dose prescription in cobalt Gray equivalent (CGE) for gross tumor volume (GTV) was 66CGE and for planning target volume (PTV), 62.7CGE. Dose-volume histograms (DVH) were used to evaluate the difference in dosimetric distributions for the target volume and the organs at risk (OARs). Results: Optimal target volume coverage and similar target conformation were achieved in both PBT and IMXT. Median conformity index was 0.72 and 0.75 (p=0.15) and median inhomogeneity coefficient was 0.14 and 0.10 (p=0.08) for PBT and IMXT, respectively. Dose to OARs was significantly lower in PBT plans than IMXT. Median maximal dose to the brainstem was 27.89CGE(cobalt Gray equivalent) and 42.45Gy (p< 0.01), and the dose to 5% of the brainstem(D5) was 12.83CGE and 19.47Gy (p< 0.001 ), for PBT and IMXT, respectively. Median maximal dose to the spinal cord was 8.38CGE and 22.91Gy (p< 0.004), and the dose to 5% of the spinal cord was 2.18CGE and 13.62Gy (p< 0.001), for PBT and IMXT, respectively. Conclusions: The use of PBT, when compared with IMXT, resulted in similar levels of tumor conformation. PBT, however, exposed the OARs to a significantly lower dose, effectively sparing the brainstem, spinal cord, optic nerve and chiasm, temporal lobes and parotid glands. The superior dose distributions possible with PBT should translate into reduced morbidity and improved quality of life.
Effects on radiation oncology treatments involving various	neuromodulation devices
Authors: Gossman Michael S. , Paralikar Kunal J. , Hebb Adam O. , Wilkinson Jeffrey D. , Graves-Calhoun Alison R. , Lawson Raymond C. , Lopez Jeffrey P. , Powell James S. 
Published: November 2024

Object: Where no society-based or manufacturer guidance on radiation limits to neuromodulation devices is available, this research provides the groundwork for neurosurgeons and radiation oncologists who rely on the computerized treatment plan clinically for cancer patients. The focus of the article is to characterize radiation parameters of attenuation and scatter when an incident therapeutic x-ray beam is directed upon them. At the time of this writing, manufacturers of Neuromodulation products do not recommend direct exposure of the device in the beam nor provide guidance for the maximum dose for these devices. Methods: Ten neuromodulation models were chosen to represent the finite class of devices marketed by Medtronic before 2011. CT simulations permitted computer treatment modeling for dose distribution analysis as used routinely in radiation oncology for patients. Phantom case results were directly compared to actual clinical patient cases. Radiation detection measurements were then correlated to computational results. Where the x-ray beam passes through the device and is attenuated, dose reduction was identified with Varian Eclipse computer modeling for these posterior locations. Results: Although the computer algorithm did not identify physical processes of side-scatter and back-scatter, these phenomena were proven by radiation measurement to occur. In general, the computer results underestimated the level of change seen by measurement. Conclusions: For these implantable neurostimulators, the spread in dose changes were found to be −6.2% to −12.5% by attenuation, +1.7% to +3.8% by side-scatter, and +1.1% to +3.1% by back-scatter at 6 MV. At 18 MV, these findings were observed to be −1.4% to −7.0% by attenuation, +1.8% to 5.7% by side-scatter, and 0.8% to 2.7% by back-scatter. No pattern for the behavior of these phenomena was deduced to be a direct consequence of device size.
Novel applications of diagnostic X-rays in activating a clinical	photodynamic drug: Photofrin II through X-ray induced visible luminescence from	"rare-earth" formulated particles
Authors: Abliz Erkinay , Collins Joshua E. , Bell Howard , Tata Darrell B. 
Published: November 2024

Introduction: In this communication we report on a novel non-invasive methodology in utilizing "soft" energy diagnostic X-rays to indirectly activate a photo-agent utilized in photodynamic therapy (PDT): Photofrin II (Photo II) through X-ray induced luminescence from Gadolinium Oxysulfide (20 micron dimension) particles doped with Terbium: Gd $_{2}$ O $_{2}$ S:Tb. Photodynamic agents such as Photo II utilized in PDT possess a remarkable property to become preferentially retained within the tumor's micro-environment. Upon the photo-agent's activation through (visible light) photon absorption, the agents exert their cellular cytotoxicity through type I and type II pathways through extensive generation of reactive oxygen species (ROS); namely, singlet oxygen $^{1}$ O $_{2}$ , superoxide anion O $_{2}^{-}$ , and hydrogen peroxide H $_{2}$ O $_{2}$ , within the intra-tumoral environment. Unfortunately, due to shallow visible light penetration depth (∼ 2 mm to 5 mm) in tissues, the current PDT strategy has largely been restricted to the treatment of surface tumors, such as the melanomas. Additional invasive strategies through optical fibers are currently utilized in getting the visible light into the intended deep seated targets within the body for PDT. Methods: X-ray induced visible luminescence from Gd $_{2}$ O $_{2}$ S:Tb particles were spectroscopically characterized, and the potential in-vitro cellular cytotoxicity of Gd $_{2}$ O $_{2}$ S:Tb particles on human glioblastoma cells (due to 48 Hrs Gd $_{2}$ O $_{2}$ S:Tb particle exposure) was screened through the MTS cellular metabolic assay. In-vitro human glioblastoma cellular exposures in presence of Photo II with Gd $_{2}$ O $_{2}$ S:Tb particles were performed in the dark in sterile 96 well tissue culture plates, and the corresponding changes in the metabolic activities of the glioblastoma due to 15 minutes of (diagnostic energy) X-ray exposure was determined 48 Hrs after treatment through the MTS assay. Results: Severe suppression (> 90% relative to controls) in the cellular metabolic activity of human glioblastoma was measured due to the treatment of clinically relevant concentrations of 20 μg/ml Photo II, with Gd $_{2}$ O $_{2}$ S:Tb particles, and (120 kVp) diagnostic X-rays. Taken together, the in-vitro findings herein provide the basis for future studies in determining the safety and efficacy of this non-invasive X-ray induced luminescence strategy in activating photo-agent in deep seated tumors.
BOARD DIVERSITY AGAINST FIRM VALUE IN CORPORATE GOVERNANCE PERSPECTIVE
Authors: Syahputri Alvina Dwi , Biduri Sarwenda , Hariyanto Wiwit , Noor Abidin Fityan Izza , Utomo Prasetyo 
Published: November 2024

Research Purposes: The study aims to find out the impact of board diversity on the firm value from the perspective of corporate governance for food and beverage industry manufacturing companies listed on the Indonesia Stock Exchange in 2016–2022.
Methods: Sampling in this study used the purposive sampling method taken from the annual reports of companies in the food and beverage manufacturing sector for 2016–2022.
Finding: It was found that the term and nationality of the board of directors has an effect on firm value. While gender diversity, age and educational background of the board of directors has no effect on firm value.
Novelty: In this study the authors focus on board diversity with complete indicators. Previous research only uses gender, nationality, and education as free variables. In this study, authors add two free variables that is tenure and age. And unlike previous studies that used chemical sector companies as research objects, this study used food and beverage industry manufacturing companies as the research object.
TAX PLANNING, INFORMATION ASYMMETRY AND FREE CASH FLOW TO EARNINGS MANAGEMENT WITH GOOD CORPORATE GOVERNANCE AS A MODERATING VARIABLE
Authors: Eri Anggraeni  , Eny Maryanti  , Cicik Suciati  , Nihlatul Qudus Sukma Nirwana  
Published: November 2024

This research was conducted with the aim of examining the effect of tax planning, information asymmetry and free cash flow on earnings management, as well as good corporate governance as a moderator of the relationship between tax planning, information asymmetry and free cash flow on earnings management. The data used is in the form of annual reports of companies in the goods & consumer industry sector listed on the Indonesia Stock Exchange (IDX) for the 2018-2021 period. The method used is quantitative with an analytical tool in the form of multiple linear regression. The results show that tax planning and information asymmetry have an effect on earnings management, while free cash flow has no effect on earnings management. Good corporate governance is able to moderate the relationship between tax planning, information asymmetry and free cash flow on earnings management. The implications of this research are expected to make a positive contribution to investors and creditors to be more careful in assessing management performance, company conditions and understanding reported earnings, because these profits are not necessarily true profits. This research is expected to provide input for companies to observe earnings management activities carried out by management for the benefit of management itself.
Association between serum free fatty acids and gestational diabetes mellitus
Authors: Li Danyang , Du Haoyi , Wu Na 
Published: November 2024

BackgroundPregnant women with gestational diabetes mellitus (GDM) are at an increased risk of adverse pregnancy outcomes (APO). Early understanding of risk factors affecting these outcomes may facilitate preventive interventions for women at high risk. Blood samples from GDM and control pregnant women were collected for Free fatty acid (FFA) profiling to determine the relationship with the occurrence of APO in GDM pregnant women.MethodsThe study comprised 144 women diagnosed with GDM and 52 normal control pregnancy (NC). Venous fasting serum samples were collected during the second trimester. The serum FFA levels were detected by liquid chromatography-mass spectrometry (LC-MS). The primary outcome consisted of serious maternal and neonatal adverse events ( hypertensive disorder complicating pregnancy (HDCP), emergency cesarean section, large for gestational age (LGA), small for gestational age (SGA), macrosomia, low birth weight (LBW), preterm birth, and stillbirth). The association of metrics with outcomes was assessed, and receiver operating characteristic (ROC) curve analysis was employed to evaluate clinical utility.ResultsDifferences in fatty acid profiles were observed between GDM patients and controls. Stearic acid (C18:0) levels differed between the normal pregnancy outcome (NPO) and APO groups, potentially correlating with fetal sex. Logistic regression models indicated that moderate and high levels of C18:0 were negatively associated with APO relative to the NPO group. ROC analysis demonstrated that C18:0 had a certain predictive ability for APO, and predictive efficiency was enhanced when combined with general clinical data.ConclusionThe level of C18:0 was associated with the occurrence of APO in pregnant women with GDM and exhibited a certain predictive value. When C18:0 was combined with general clinical data, the predictive power for APO was improved.
Hyperlipidemia and apolipoprotein E are associated with intraocular pressure of thyroid-associated ophthalmopathy in a Chinese population: a cross-sectional study
Authors: Chen Yu , Qi Xin , Wang Jingya , Xu Huayang , Sun Yushi , Wang Ling , Zhou Xingchen , He Mingqian , Zhao Jiarui , Zhang Jinbo , He Hairong , Guo Hui , Shi Bingyin , Wang Yue , Zhang Meng 
Published: November 2024

ObjectiveThis study aimed to explore the clinical characteristics of thyroid-associated ophthalmopathy (TAO) with hyperlipidemia and to identify the key lipid indicator.MethodsPatients with TAO were recruited to this study and divided into two groups based on the presence of hyperlipidemia. TAO patients with hyperlipidemia were further classified based on the type of hyperlipidemia. Basic and clinical information of the patients were collected, and comparisons between groups were carried out. Correlation analyses, regression analyses, and stratified analysis were performed to assess the correlations and relationship of the serum lipids with the ophthalmic indicators.ResultsA total of 273 patients with TAO were recruited, including 158 patients with hyperlipidemia and 115 patients without hyperlipidemia. Patients with hyperlipidemia, especially those with mixed hyperlipidemia, exhibited high intraocular pressure (IOP). Spearman’s correlation analysis and partial correlation analysis showed that apolipoprotein E (ApoE) was positively related to IOP levels after controlling for confounding factors, including age, gender, BMI, smoking history, triiodothyronine (T3), and thyrotropin (thyroid-stimulating hormone, TSH). Moreover, multiple linear regression obtained a regression equation including ApoE, gender, age, and BMI and showed that elevated ApoE levels were associated with elevated IOP [β = 0.072, 95% confidence interval (CI) = 0.037–0.155, p = 0.030]. Stratified analysis highlighted the impact of ApoE on IOP in younger patients (≤48 years), female patients, patients with normal BMI (&lt;24 kg/m2), and patients with a shorter course of ophthalmopathy (≤6 months).ConclusionOverall, higher IOP levels were observed in patients with hyperlipidemia, especially those with mixed hyperlipidemia. Notably, a higher ApoE was identified as an independent risk factor for higher IOP. This finding confirmed the close relationship between TAO and lipid metabolism and provides a new insight into the pathogenesis research and the long-term management of TAO.