bluuebunny/crossref_metadata_2025_split huggingface dataset:
Azacitidine maintenance after intensive chemotherapy improves DFS in older AML patients
Authors: Huls Gerwin , Chitu Dana A. , Havelange Violaine , Jongen-Lavrencic Mojca , van de Loosdrecht Arjan A. , Biemond Bart J. , Sinnige Harm , Hodossy Beata , Graux Carlos , Kooy Rien van Marwijk , de Weerdt Okke , Breems Dimitri , Klein Saskia , Kuball Jürgen , Deeren Dries , Terpstra Wim , Vekemans Marie-Christiane , Ossenkoppele Gert J. , Vellenga Edo , Löwenberg Bob ,   the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON)
Published: January 2019

Abstract
The prevention of relapse is the major therapeutic challenge in older patients with acute myeloid leukemia (AML) who have obtained a complete remission (CR) on intensive chemotherapy. In this randomized phase 3 study (HOVON97) in older patients (≥60 years) with AML or myelodysplastic syndrome with refractory anemia with excess of blasts, in CR/CR with incomplete hematologic recovery (CRi) after at least 2 cycles of intensive chemotherapy, we assessed the value of azacitidine as postremission therapy with respect to disease-free survival (DFS; primary end point) and overall survival (OS; secondary end point). In total, 116 eligible patients were randomly (1:1) assigned to either observation (N = 60) or azacitidine maintenance (N = 56; 50 mg/m2, subcutaneously, days 1-5, every 4 weeks) until relapse, for a maximum of 12 cycles. Fifty-five patients received at least 1 cycle of azacitidine, 46 at least 4 cycles, and 35 at least 12 cycles. The maintenance treatment with azacitidine was feasible. DFS was significantly better for the azacitidine treatment group (logrank; P = .04), as well as after adjustment for poor-risk cytogenetic abnormalities at diagnosis and platelet count at randomization (as surrogate for CR vs CRi; Cox regression; hazard ratio, 0.62; 95% confidence interval, 0.41-0.95; P = .026). The 12-month DFS was estimated at 64% for the azacitidine group and 42% for the control group. OS did not differ between treatment groups, with and without censoring for allogeneic hematopoietic cell transplantation. Rescue treatment was used more often in the observation group (n = 32) than in the azacitidine maintenance group (n = 9). We conclude that azacitidine maintenance after CR/CRi after intensive chemotherapy is feasible and significantly improves DFS. The study is registered with The Netherlands Trial Registry (NTR1810) and EudraCT (2008-001290-15).
Court diversion for those with psychosis and its impact on re-offending rates: results from a longitudinal data-linkage study
Authors: Albalawi Olayan , Chowdhury Nabila Zohora , Wand Handan , Allnutt Stephen , Greenberg David , Adily Armita , Kariminia Azar , Schofield Peter , Sara Grant , Hanson Sarah , O'Driscoll Colman , Butler Tony 
Published: January 2019

BackgroundWith significant numbers of individuals in the criminal justice system having mental health problems, court-based diversion programmes and liaison services have been established to address this problem.AimsTo examine the effectiveness of the New South Wales (Australia) court diversion programme in reducing re-offending among those diagnosed with psychosis by comparing the treatment order group with a comparison group who received a punitive sanction.MethodThose with psychoses were identified from New South Wales Ministry of Health records between 2001 and 2012 and linked to offending records. Cox regression models were used to identify factors associated with re-offending.ResultsA total of 7743 individuals were identified as diagnosed with a psychotic disorder prior to their court finalisation date for their first principal offence. Overall, 26% of the cohort received a treatment order and 74% received a punitive sanction. The re-offending rate in the treatment order group was 12% lower than the punitive sanction group. ‘Acts intended to cause injury’ was the most common type of the first principal offence for the treatment order group compared with the punitive sanction group (48% v. 27%). Drug-related offences were more likely to be punished with a punitive sanction than a treatment order (12% v. 2%).ConclusionsAmong those with a serious mental illness (i.e. psychosis), receiving a treatment order by the court rather than a punitive sanction was associated with reduced risk for subsequent offending. We further examined actual mental health treatment received and found that receiving no treatment following the first offence was associated with an increased risk of re-offending and, so, highlighting the importance of treatment for those with serious mental illness in the criminal justice system.
Cost-effectiveness analysis of telephone cognitive–behaviour therapy for adolescents with obsessive–compulsive disorder
Authors: Tie Hiong , Krebs Georgina , Lang Katie , Shearer James , Turner Cynthia , Mataix-Cols David , Lovell Karina , Heyman Isobel , Byford Sarah 
Published: January 2019

BackgroundTelephone cognitive–behaviour therapy (TCBT) may be a cost-effective method for improving access to evidence-based treatment for obsessive–compulsive disorder (OCD) in young people.AimsEconomic evaluation of TCBT compared with face-to-face CBT for OCD in young people.MethodRandomised non-inferiority trial comparing TCBT with face-to-face CBT for 72 young people (aged 11 to 18) with a diagnosis of OCD. Cost-effectiveness at 12-month follow-up was explored in terms of the primary clinical outcome (Children's Yale-Brown Obsessive-Compulsive Scale, CY-BOCS) and quality-adjusted life-years (QALYs) (trial registration: ISRCTN27070832).ResultsTotal health and social care costs were higher for face-to-face CBT (mean total cost £2965, s.d. = £1548) than TCBT (mean total cost £2475, s.d. = £1024) but this difference was non-significant (P = 0.118). There were no significant between-group differences in QALYs or the CY-BOCS and there was strong evidence to support the clinical non-inferiority of TCBT. Cost-effectiveness analysis suggests a 74% probability that face-to-face CBT is cost-effective compared with TCBT in terms of QALYs, but the result was less clear in terms of CY-BOCS, with TCBT being the preferred option at low levels of willingness to pay and the probability of either intervention being cost-effective at higher levels of willingness to pay being around 50%.ConclusionsAlthough cost-effectiveness of TCBT was sensitive to the outcome measure used, TCBT should be considered a clinically non-inferior alternative when access to standard clinic-based CBT is limited, or when patient preference is expressed.Declaration of interestD.M.-C. reports research grants from the Swedish Research Council (Vetenskapsrådet), the Swedish Research Council for Health, working life and welfare (Forte), the US National Institute of Mental Health (NIMH), the UK National Institute of Health Research (NIHR), as well as royalties from Wolters Kluwer Health and Elsevier, all unrelated to the submitted work.
Fully Automatic Treatment Planning for External-Beam Radiation Therapy of Locally Advanced Cervical Cancer: A Tool for Low-Resource Clinics
Authors: Kisling Kelly , Zhang Lifei , Simonds Hannah , Fakie Nazia , Yang Jinzhong , McCarroll Rachel , Balter Peter , Burger Hester , Bogler Oliver , Howell Rebecca , Schmeler Kathleen , Mejia Mike , Beadle Beth M. , Jhingran Anuja , Court Laurence 
Published: January 2019

Purpose The purpose of this study was to validate a fully automatic treatment planning system for conventional radiotherapy of cervical cancer. This system was developed to mitigate staff shortages in low-resource clinics. Methods In collaboration with hospitals in South Africa and the United States, we have developed the Radiation Planning Assistant (RPA), which includes algorithms for automating every step of planning: delineating the body contour, detecting the marked isocenter, designing the treatment-beam apertures, and optimizing the beam weights to minimize dose heterogeneity. First, we validated the RPA retrospectively on 150 planning computed tomography (CT) scans. We then tested it remotely on 14 planning CT scans at two South African hospitals. Finally, automatically planned treatment beams were clinically deployed at our institution. Results The automatically and manually delineated body contours agreed well (median mean surface distance, 0.6 mm; range, 0.4 to 1.9 mm). The automatically and manually detected marked isocenters agreed well (mean difference, 1.1 mm; range, 0.1 to 2.9 mm). In validating the automatically designed beam apertures, two physicians, one from our institution and one from a South African partner institution, rated 91% and 88% of plans acceptable for treatment, respectively. The use of automatically optimized beam weights reduced the maximum dose significantly (median, −1.9%; P < .001). Of the 14 plans from South Africa, 100% were rated clinically acceptable. Automatically planned treatment beams have been used for 24 patients with cervical cancer by physicians at our institution, with edits as needed, and its use is ongoing. Conclusion We found that fully automatic treatment planning is effective for cervical cancer radiotherapy and may provide a reliable option for low-resource clinics. Prospective studies are ongoing in the United States and are planned with partner clinics.
The N-cadherin interactome in primary cardiomyocytes as defined using quantitative proximity proteomics
Authors: Li Yang , Merkel Chelsea D. , Zeng Xuemei , Heier Jonathon A. , Cantrell Pamela S. , Sun Mai , Stolz Donna B. , Watkins Simon C. , Yates Nathan A. , Kwiatkowski Adam V. 
Published: January 2019

ABSTRACT
The junctional complexes that couple cardiomyocytes must transmit the mechanical forces of contraction while maintaining adhesive homeostasis. The adherens junction (AJ) connects the actomyosin networks of neighboring cardiomyocytes and is required for proper heart function. Yet little is known about the molecular composition of the cardiomyocyte AJ or how it is organized to function under mechanical load. Here, we define the architecture, dynamics and proteome of the cardiomyocyte AJ. Mouse neonatal cardiomyocytes assemble stable AJs along intercellular contacts with organizational and structural hallmarks similar to mature contacts. We combine quantitative mass spectrometry with proximity labeling to identify the N-cadherin (CDH2) interactome. We define over 350 proteins in this interactome, nearly 200 of which are unique to CDH2 and not part of the E-cadherin (CDH1) interactome. CDH2-specific interactors comprise primarily adaptor and adhesion proteins that promote junction specialization. Our results provide novel insight into the cardiomyocyte AJ and offer a proteomic atlas for defining the molecular complexes that regulate cardiomyocyte intercellular adhesion.
This article has an associated First Person interview with the first authors of the paper.
Multiple Glass-Transitions of Globular Protein BSA Aqueous Solutions Depending on the Hydration Degree
Authors: Watanabe Keisuke , Kawai Kiyoshi , Nagoe Atsushi , Suzuki Toru , Oguni Masaharu 
Published: January 2019

Abstract
Glass-transition behavior of hydrated bovine serum albumin (BSA) aqueous solutions depending on hydration degree within 0.05 and 0.43 h (water-g/protein-g) was investigated according to the measurement of an enthalpy-relaxation rate deduced from the temperature drift observed by adiabatic calorimetry. The results showed that an increase in hydration degree enlarged the temperature range in which the enthalpy-relaxation effects emerged. The BSA sample in hydration degree around 0.05 h showed one Tg peak, and further hydration to 0.24 h led to up to three distinguishable Tg, and finally BSA solution of 0.43 h showed cold crystallization due to the portion of water molecules included. The multiplicity of the Tg in the well-hydrated BSA is explained as follows: At sufficiently low temperatures, ∼50 K, the hydrated BSA molecule and the contained water molecules are completely frozen. Then, heating induces mobility of some of the water molecules initially, and further causes the sequential unfreezing of the polar side chains of BSA molecules, coupling with the directly hydrating water molecules, and, in turn, of the main chains of the BSA molecule. This interpretation may integrate the unique insights of glass transition behavior of hydrated proteins into a consensus.
Reactions between 5-Nitroso-1,3-diphenyltetrazolium Salts and Electron-Rich Arenes, Amines, Thiophenol, Sulfoxides, and Thioanisole
Authors: Matsukawa Yuta , Hirashita Tsunehisa , Araki Shuki 
Published: January 2019

Abstract
A series of reactions between 5-nitroso-1,3-diphenyltetrazolium tetrafluoroborate and methoxybenzenes, amines, thiols, sulfoxides, and sulfides, most of which are generally accepted as being inert to nitroso groups, is reported here. The tetrazolium-activated nitroso functionality is capable of oxidizing the aforementioned substrates to give the corresponding oxidized products, and the nitroso tetrazolium itself is transformed into the corresponding amide or hydroxyamide, depending on the nature of the reaction partners. In the case of thioanisole, an addition product was obtained.
ANTHROPOGENIC FACTORS DRIVING PHOSPHORUS CONTENTS IN SALTO GRANDE RESERVOIR SEDIMENTS, SÃO PAULO STATE (SE BRAZIL) / INFLUÊNCIA ANTROPOGÊNICA NAS CONCENTRAÇÕES DE FÓSFORO DOS SEDIMENTOS DO RESERVATÓRIO DE SALTO GRANDE, ESTADO DE SÃO PAULO (SE BRASIL)
Authors: Misailidis Maria Laura , Machado Wilson , Segovia Alexander Perez , Strikis Nicolás Misailidis , Strikis Pedro Carlos , Pregnolato Leonardo Antonio , Duleba Wânia 
Published: January 2019

Phosphorus is an essential element for life and, when scarce, this macronutrient is a limiting factor for primary production. Phosphorus (P) is a widely used element in the composition of fertilizers, besides being present in large quantities in domestic effluents. Its accumulation in the springs is related to the proliferation of algae and cyanobacteria. In excess, P is a pollutant that contributes greatly to the eutrophication, development of reduced conditions and deterioration of water bodies. In order to understand how the anthropogenic action affected the accumulation of P in the freshwater reservoir of Salto Grande, Americana City (São Paulo State, Brazil), the evaluation of a temporal sedimentary record was carried out. For this purpose, a sediment core collected in the reservoir of Salto Grande was studied. The sediment core recorded the reservoir history since its filling in 1950. The comparison of P concentrations along the core with the population growth curve indicates that the population growth in the surrounding region has had a direct impact on the accumulation of P in the freshwater reservoir of Salto Grande. The eutrophication history of this major continental ecosystem of São Paulo State, was reflected by this sewage-derived from loading of P. ResumoO fósforo é um elemento essencial para a vida e, quando escasso, esse macronutriente é um fator limitante para a produção primária. O fósforo (P) é um elemento amplamente utilizado na composição de fertilizantes, além de estar presente em grande quantidade nos efluentes domésticos. A sua acumulação nas nascentes está relacionada à proliferação de algas e cianobactérias. Em excesso, o P é um poluente que contribui grandemente para a eutrofização, desenvolvimento de condições redutoras e deterioração dos corpos d'água. Para entender como a ação antropogênica afetou o acúmulo de P no reservatório de água doce de Salto Grande, na cidade de Americana, Estado de São Paulo (SE Brasil) foi realizada a avaliação de um registro temporal sedimentar. Para tanto, foi estudado um testemunho de sedimentos de 2,37m coletado no reservatório de Salto Grande. O testemunho registrou a história do reservatório desde seu preenchimento, em 1950. A comparação das concentrações de P ao longo do testemunho com a curva de crescimento populacional e de pluviosidade indica que estas variáveis tiveram um impacto direto no acúmulo de P no reservatório de água doce de Salto Grande.
DIÁLOGOS PERTINENTES ACERCA DA UTILIZAÇÃO DE RECURSOS EDUCACIONAIS ABERTOS PARA A EDUCAÇÃO
Authors: Pinto Anamelea De Campos , Silva Júlio César Correia da , Mercado Luis Paulo 
Published: January 2019

A crescente profusão e difusão das tecnologias digitais de informação e comunicação (TDIC) possibilitaram a criação de novas práticas de ensino que incorporam a utilização de recursos multimidiáticos como facilitadores do processo de ensino e aprendizagem dos sujeitos conectados. Nesse sentido, os Recursos Educacionais Abertos (REA) surgem como uma proposta inovadora para o campo da educação e tem como objetivo constituir autores digitais mais responsáveis na edificação e partilha do conhecimento, possibilitando a engendração do conceito de abertura e liberdade face as especificidades do licenciamento em Creative Commons (CC) e as etapas de produção e execução dos REA. Para nortear a construção do artigo, que se caracteriza como uma pesquisa teórica acerca do usabilidade de REA, buscou-se em Silva et al (2017), Amiel (2012), Pesce (2013), Santana et al (2012) e Litto e Mattar (2017) respostas para solucionar tais problemáticas: Quais elementos são essenciais para a construção e usabilidade dos REA? De que forma podemos propor a usabilidade desses recursos para a educação? Desse modo descobriu-se que o alicerce deste artigo está na forma de investigar e consultar a importância do uso dos REA como uma política pública educacional, sobretudo na proposta epistemológica da Teoria Conectivista e nas contribuições históricas da Educação Aberta pela qual a (co)produção e a (co)aprendizagem dos REA se apoia. Como resultado, apresentamos a proposição de alguns elementos norteadores da construção, execução e utilização dos REA, promovendo diálogos pertinentes para a preparação de um guia de recomendações de usabilidade, abordando conteúdos introdutórios acerca da temática em tela e propondo como um dos elementos a formatação de uma plataforma online híbrida, que denominamos de restart, para organizar e contabilizar obras em REA ou transformadas em Domínio Público, complementando as cinco liberdades essenciais para a condução dos REA, que são: revisar, reutilizar, remixar e redistribuir. A finalidade desse estudo é discutir as formas de licenciamento em CC, o acesso aos recursos, um método de trabalho que leve em consideração a saúde, bem-estar e segurança dos usuários e produtores de REA e assegurar uma avaliação aberta na concepção dos REA, trazendo tais peculiaridades como componentes do guia, que estejam em conformidade com as suas bases legais-normatizadoras.
Concepções de Docentes sobre o uso de Metodologias Ativas da Aprendizagem: Um Enfoque na Formação de Enfermeiros
Authors: Oliveira Gésica Kelly Da Silva , Rodrigues Kátia Calligaris , Freitas Maria Aparecida De Oliveira 
Published: January 2019

As vertiginosas mudanças na conjuntura social têm posto em reflexão, de maneira contundente, os aspectos relacionados a formação profissional em enfermagem. Assim, esta discussão surge mediante a necessidade de considerar os fatores que são próprios do trabalho em saúde, tais como a relação intrínseca entre as atividades práticas e a teoria, o cuidado holístico, crítico e humanizado, visto que estes elementos são essenciais para o apropriado exercício profissional. Este trabalho objetivou investigar a percepção dos docentes do curso de graduação em enfermagem sobre a utilização e contribuição das metodologias ativas da aprendizagem no processo de formação e desenvolvimento do profissional enfermeiro. Trata-se de um estudo de natureza qualitativa de caráter exploratório-descritivo, que foi realizado com docentes de um Centro Universitário do Agreste Pernambucano. Os dados foram coletados por meio de entrevista semiestruturada, para apreciação dos dados obtidos foirealizada análise de conteúdo, seguindo o referencial teórico proposto por Minayo. Os resultados demonstraram que os docentes compreendem a relevância das metodologias ativas para a formação em enfermagem, entretanto evidenciamos não haver um planejamento de um ensino ativo, pelo professor, demonstrando afinidade com a transmissão de conteúdos, o que sinaliza a importância da atitude reflexiva constante no campo da docência em enfermagem.
Important implementation constructs for federal agencies in health and human service settings that are selecting, monitoring, and supporting grantees
Authors: Dymnicki Allison , Bzura Robin , Osher David , Wandersman Abraham , Duplantier Dan , Boyd Michelle , Cash Amanda , Hutchison Lindsey 
Published: January 2019

Background:Federal agencies and other funders seeking to maximise their impact aim to understand factors associated with implementing evidence-based interventions (EBIs) to address health problems. Challenges exist, however, in synthesising information from different disciplines and reaching agreement about these factors due to different terminology, frameworks, and measures being used in different fields.
Methods:A mixed-methods approach was used to identifying a set of implementation constructs helpful for selecting, monitoring, and supporting federal grantees in health and human service settings. Three phases of research were conducted: a literature review, structured expert interviews, and consensus building. Interviews with implementation experts were used to validate a set of implementation constructs identified in the literature review as strongly and consistently related to successful implementation of EBIs in international contexts. A modified Delphi approach was used with a technical working group (TWG) of federal staff to agree on the constructs most relevant for federally funded EBIs.
Findings:This process yielded 11 constructs related to either the intervention, the intersection between the invention and context, or the implementation process. These constructs are areas of interest when integrating research evidence into routine practice. Expert interviewees recommended establishing clear, consistent construct definitions before developing valid, feasible measures of the constructs. In contrast to the numerous and specific constructs advanced by researchers, federal TWG members favoured fewer constructs with more generalisability.
Discussion and conclusions:This article demonstrates the translation work required for policy contexts and highlights a successful approach to translate evidence from implementation science research for federal staff.