bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modern Trends in the Breast Cancer Conserving Surgery and Oncoplastic Breast Surgery
Authors: Зикиряходжаев А. , Zikiryahodjaev A. , Ермощенкова М. , Ermoshchenkova M. , Каприн А. , Kaprin A. , Чиссов В. , Chissov V. , Запиров М. , Zapirov M. 
Published: December 2018

Introduction: The highest priority for modern clinical oncology is functionally-sparing and organ-conserving treatment. In Russia, breast cancer (BC), among all malignant tumors, accounted for 21.1 % of women in 2017. Oncoplastic radical resections (OPS-BCS = oncoplastic surgery – breast conserving surgery) have been widely used. This term means resection of the breast for cancer using plastic surgery to restore the shape of the breast, in most cases with one-stage correction of the contralateral breast. Purpose: It was the creation of various techniques of oncoplastic breast surgery, applicable for the appropriate localization of breast cancer and the evaluation of surgical, oncological and aesthetic results. Methods: From 2013 to 2017, in the P.A. Hertsen Moscow Oncology Research Center, organ-conserving surgery were performed in 570 patients with BC with an average age of 54.2. Stage 0 was diagnosed in 4.6 %, I – 5.9 %, IIA – 28.7 %, IIB – 6 %, IIIA – 5.1 %, IIIC – 3.3 %, IIIB – 0.2 %, IV – 0.2 %. Radical resection in the standard version was performed in 290 patients with breast cancer, oncoplastic breast surgery in various modifications – in 280. All patients after the organ-conserving surgical treatment received radiation therapy. Patients received chemotherapy, targeted therapy and hormone therapy according to the indications in depending the disease stage and the immunohistochemical type of the tumor. Results: After an urgent and planned morphological study positive margins of resection were revealed in 10 patients, which required reresection of the edges to a negative state of them in case of an urgent intraoperative response and mastectomy – in case of a planned response. Within 4 years, local recurrences were detected in 4 patients (0.7 %), which required a mastectomy with a one-stage reconstruction. In 1 patient (0.2 %), the disease progressed as metastases to the lung – in this case lobectomy and a necessary chemotherapy were conducted. Cosmetic results were defined as excellent in 70 % cases, good – 25 %, satisfactory – 5 %. Conclusion: If there are indications for organ-conserving treatment of breast cancer and the patient’s decision concerning this surgery, the patient should be offered methods of oncoplastic surgery for the prevention of psychological and emotional stress, effective rehabilitation, and a quick return to active social life.
Archaeometry of Roman Aquitania-Tarraconensis coarse ware pottery from the northern Iberian Peninsula and southern Aquitania
Authors: Alonso-Olazabal Ainhoa , Martínez Salcedo Ana , Esteban Delgado Milagros , Izquierdo Maria Teresa , Ortega Luis Angel , Zuluaga Maria Cruz , Réchin François 
Published: December 2018

Abstract
Atrial Fibrillation and Exercise: Exercise Recommendations
Authors: Sorace Paul , Ronai Peter , Berry Robert 
Published: December 2018

ABSTRACT
ATRIAL FIBRILLATION (AF) IS CHARACTERIZED BY A RAPID PULSE RATE AND AN IRREGULAR HEART RHYTHM. IT IS A MORE COMMON CARDIAC ARRHYTHMIA. AF MAY LACK SYMPTOMS, ALTHOUGH FATIGUE AND AN IMPAIRED EXERCISE ABILITY ARE COMMON SYMPTOMS. THIS COLUMN WILL DISCUSS EXERCISE TESTING AND TRAINING RECOMMENDATIONS AS WELL AS SPECIAL CONSIDERATIONS.
Autoimmune hypoglycaemia caused by alpha-lipoic acid: a rare condition in Caucasian patients
Authors: Veltroni A , Zambon G , Cingarlini S , Davì M V 
Published: December 2018

Summary
Insulin autoimmune syndrome (IAS), a rare cause of autoimmune hyperinsulinaemic hypoglycaemia, is relatively well known in Japan. The incidence in Caucasians is less than one-fifth of that reported in Japanese people, but it is becoming increasingly recognised worldwide in non-Asians as well. Drugs containing sulphydryl groups are known to be associated with the disease in genetically predisposed individuals. Moreover, several recent reports showed a direct association between the onset of IAS and the consumption of dietary supplements containing alpha-lipoic acid (LA). Insulinoma remains the most prevalent cause of hypersulinaemic hypoglycaemia in Caucasians. Consequently, primary investigation in these patients is generally focused on localisation of the pancreatic tumour, often with invasive procedures followed by surgery. We described a case of an Italian woman presenting to us with severe recurrent hypoglycaemia associated with high insulin and C-peptide levels and no evidence of pancreatic lesions at imaging diagnostic procedures. She had taken LA until 2 weeks before hospitalisation. After an evaluation of her drug history, an autoimmune form of hypoglycaemia was suspected and the titre of insulin autoantibodies was found to be markedly elevated. This allowed us to diagnose LA-related IAS, thus preventing any unnecessary surgery and avoiding invasive diagnostic interventions.

Learning points:

IAS is a rare cause of hyperinsulinaemic hypoglycaemia that typically affects Asian population, but it has been increasingly recognised in Caucasian patients.

It should be considered among the differential diagnosis of hyperinsulinaemic hypoglycaemia to avoid unnecessary diagnostic investigations and surgery.

It should be suspected in the presence of very high serum insulin levels (100–10  000  μU/mL) associated with high C-peptide levels.

There is a strong association with administration of drugs containing sulphydryl groups included LA, a dietary supplement commonly used in Western countries to treat peripheral neuropathy.
Optimizing Patient Management in Crohn’s Disease in a Tertiary Referral Center: the Impact of Fast-Track MRI on Patient Management and Outcomes
Authors: Ilias Akos , Lovasz Barbara D , Gonczi Lorant , Kurti Zsuzsanna , Vegh Zsuzsanna , Sumegi Liza D , Golovics Petra A , Rudas Gabor , Lakatos Peter L 
Published: December 2018

Background & Aims: Rapid optimization of treatment algorithms and disease outcomes requires an objective measurement of disease activity in patients with Crohn’s disease (CD). Our aim was to evaluate the impact of rapid-access to magnetic resonance imaging (MRI) on treatment optimization, clinical decision-making and outcomes for CD patients in a specialized tertiary care for inflammatory bowel disease (IBD) patients.Methods: A cohort of 75 referral CD patients (median age: 34, IQR: 25-43 years) who had underwent 90 fasttrack MR enterography (MRE) scans between January 2014 and June 2016 were retrospectively enrolled. The MRI results were compared to clinical activity scores and biomarkers (C-reactive protein). The immediate impact of fast-track MRI on clinical decision-making, including changes in medical therapy, the need of hospitalization and surgery were evaluated.Results: The location of CD was ileo-colonic in 61% of the patients with perianal fistulas in 56% and previous surgeries in 55%. The indication for fast-track MRI scans was active disease (clinical or biomarker activity) in 55.6%. The radiological activity (including mild radiological signs to severe lesions) was detected in 94% of cases. Significant/severe MRI activity was depicted in 68% of these patients. Correlation between MRI radiological activity and clinical disease activity or colonoscopy was moderate (kappa: 0.609 and 0.652). A change in therapeutic strategy was made in 94.1% of cases with severe MRI radiological activity vs. 50% of patients without severe MRI radiological activity (p=0.001). Significant/severe MRI activity was followed by higher surgery rates among patients with clinical disease activity (50% vs. 12.5%; p=0.013). MRI performed on patients with clinical and biomarker remission identified disease activity in a significantly smaller proportion.Conclusions: Fast-track MRI had a great impact on patient management in CD patients with clinical or biomarker activity, leading to better patient stratification and faster optimization of the therapy (medical or surgical), while MRI revealed previously undiagnosed disease activity only in a small proportion of patients in clinical remission.
Neonatal Intubation Practice and Outcomes: An International Registry Study
Authors: Foglia Elizabeth E. , Ades Anne , Sawyer Taylor , Glass Kristen M. , Singh Neetu , Jung Philipp , Quek Bin Huey , Johnston Lindsay C. , Barry James , Zenge Jeanne , Moussa Ahmed , Kim Jae H. , DeMeo Stephen D. , Napolitano Natalie , Nadkarni Vinay , Nishisaki Akira ,   for the NEAR4NEOS Investigators
Published: December 2018

BACKGROUND AND OBJECTIVES:
Neonatal tracheal intubation is a critical but potentially dangerous procedure. We sought to characterize intubation practice and outcomes in the NICU and delivery room (DR) settings and to identify potentially modifiable factors to improve neonatal intubation safety.

METHODS:
We developed the National Emergency Airway Registry for Neonates and collected standardized data for patients, providers, practices, and outcomes of neonatal intubation. Safety outcomes included adverse tracheal intubation–associated events (TIAEs) and severe oxygen desaturation (≥20% decline in oxygen saturation). We examined the relationship between intubation characteristics and adverse events with univariable tests and multivariable logistic regression.

RESULTS:
We captured 2009 NICU intubations and 598 DR intubations from 10 centers. Pediatric residents attempted 15% of NICU and 2% of DR intubations. In the NICU, the first attempt success rate was 49%, adverse TIAE rate was 18%, and severe desaturation rate was 48%. In the DR, 46% of intubations were successful on the first attempt, with 17% TIAE rate and 31% severe desaturation rate. Site-specific TIAE rates ranged from 9% to 50% (P &lt; .001), and severe desaturation rates ranged from 29% to 69% (P = .001). Practices independently associated with reduced TIAEs in the NICU included video laryngoscope (adjusted odds ratio 0.46, 95% confidence interval 0.28–0.73) and paralytic premedication (adjusted odds ratio 0.38, 95% confidence interval 0.25–0.57).

CONCLUSIONS:
We implemented a novel multisite neonatal intubation registry and identified potentially modifiable factors associated with adverse events. Our results will inform future interventional studies to improve neonatal intubation safety.
STRUCTURAL ANALYSIS OF LIQUID 3D TRANSITION METALS USING CHARGED HARD SPHERE REFERENCE SYSTEM
Authors: THAKOR P. B. , GAJJAR P. N. , JANI A. R. 
Published: December 2018

The Charged Hard Sphere (CHS) reference system is applied to study the structural
analysis of liquid 3d transition metals. Here we report the structure factor S(q), pair
distribution function g (r), interatomic distance r1 of nearest neighbour atoms and coordination
number n$_1$ for liquid 3d transition metals viz: Ti, V, Cr, Mn, Fe, Co, Ni and Cu.
To describe electron–ion interaction our own model potential is employed alongwith the local
field correction due to Sarkar et al (SS). The present results of S(q) and g (r) are in
good agreement with experimental findings. The maximum discrepancy obtained from the
experimental data for the coordination number is 4.22% in the case of Ti while the lowest
is 0.31% for Cu. Thus CHS is capable of explaining the structural information of a nearly
empty d-shell, nearly filled d-shell and fully filled d-shell elements.
AXION IN PQWW MODEL AND AXION PRODUCTION IN e<sup>+</sup>e<sup>-</sup> COLLISION
Authors: SOA DANG VAN , THUC LE NHU , KHOI DINH PHAN 
Published: December 2018

Properties of the axion in PQWW model is considered. In this model, axion appears as a new phase of the Higgs field. From a general Higgs potential which is renormalizable and invariant under UPQ(1) transformation, we consider the interaction of the axion with leptons and quarks. Based on these results, axion production in e+e- collision is calculated in detail. The numerical evaluation shows that the axion can be detected in
experimental conditions.
DEPENDENCE OF THE COSMIC MUON FLUX ON ATMOSPHERIC PRESSURE AND TEMPERATURE
Authors: DIEP PHAM NGOC , NHUNG PHAM THI TUYET , DINH PHAM NGOC , DUONG NGUYEN HAI , DARRIULAT PIERRE , THAO NGUYEN THI , THIEU DANG QUANG , THUAN VO VAN 
Published: December 2018

The dependence upon atmospheric pressure of the cosmic muon flux in Hanoi
has been measured to be -1.47± 0.50 permil per mbar in agreement with expectation from a
naive estimate. The dependence over ground temperature is observed to largely reflect the
correlation existing between temperature and pressure. Once the effect of this correlation is
removed a smaller, barely significant temperature dependence of -0.57± 0.34 permil per °C
subsists.
RUSSIAN GENIUS LOMONOSOV AS A PIONEER AND POPULARIZER IN SCIENCE
Authors: Maevskaya Marina Igorevna , Gromova Ludmila Petrovna 
Published: December 2018

The article analyzes the promotional activity of outstanding Russian encyclopedist Michail Lomonosov who founded the fundamentals of science in Russia and tried to make scientific knowledge available for the wide range of readers in the XVIII century. Also, different forms of dissemination of scientific knowledge that Lomonosov used in the academic and educational activities were examined in the article.
Vigilância das síndromes neurológicas notificadas no HFSE em um contexto de epidemia de Zika, chikungunya e dengue
Authors: Pereira Alessandra Gonçalves Lisbôa , Escosteguy Claudia Caminha , Marques Márcio Renan Vinícius Espínola , Bergamo Luísa Corrêa 
Published: December 2018

Justificativa e Objetivos: a ocorrência de manifestações neurológicas no contexto da circulação dos vírus da dengue(DENV), Zika(ZIKV) e chikungunya(CHIKV) no Brasil é um desafio para a vigilância epidemiológica. Objetivo: descrever o perfil clínico-epidemiológico dos pacientes notificados no HFSE com síndromes neurológicas potencialmente associadas ao DENV, CHIKV e ZIKV, em 2015 e 2016.
Métodos: estudo observacional, com análise de bases secundárias e coleta de dados em prontuários e fichas de investigação epidemiológica do HFSE. Incluídos todos os casos notificados em 2015 e 2016, que atendessem aos critérios: a) síndrome neurológica de origem indeterminada e registro de infecção viral prévia até 60 dias antes do início do quadro neurológico, confirmados laboratorialmente ou não; b) síndrome neurológica sem registro de infecção viral prévia até 60 dias antes do início do quadro neurológico, com confirmação laboratorial para DENV, CHIKV e ZIKV em líquor, soro ou urina. Variáveis analisadas: sexo, idade, raça/cor, escolaridade, município de residência, sinais e sintomas, diagnóstico sindrômico e etiológico do quadro neurológico, local/tempo de internação e evolução.
Resultados: 72 casos notificados: 61,1% homens, idade mediana 37 anos, quadro neurológico com síndrome de Guillain-Barré(SGB) 34,7% e meningoencefalite 31,9%. Foram classificados como associados a arboviroses 39 casos (54,1%), dos quais 14 pelo critério laboratorial (3 ZIKV, 6 CHIKV, 4 DENV, 1 DENV+ CHIKV) e 25 por critério clínico-epidemiológico. Nos laboratorialmente confirmados o percentual de meningoencefalite (57,1%) ultrapassou SGB (35,7%).
Conclusão: o diagnóstico diferencial entre as arboviroses nesse contexto é um desafio para a vigilância epidemiológica, destacando-se o predomínio da SGB e das meningoencefalites.
PALAVRAS-CHAVE: infecção por arbovírus; manifestações neurológicas; Epidemiologia.
SAĞLIK İŞLETMELERİNDE MALİYET ANALİZİ: ÖZEL BİR HASTANEDE RÖNTGEN BİRİM MALİYETLERİNİN HESAPLANMASI
Authors: YOLCİ Melik , TANYILDIZI Halil 
Published: December 2018

Bütün sektörlerde olduğu gibi sağlık
sektöründe de sunulan hizmetler çoğunlukla gerçek bir maliyetlemeye tabi tutulmadan
fiyatlandırılmaktadır. Bu durum sunulan hizmetlerin bazılarının aşırı bir
şekilde bazılarının ise maliyetlerinin altında fiyatlandırılmasına neden
olmaktadır. Hastaneler için sunulan hizmetlerin maliyetlerinin ne olduğu, hangi hizmetlerin daha kârlı olduğu gibi
hususların bilinmesi büyük bir avantaj sağlayacağı için maliyetleme çalışmaları
hayati bir öneme sahiptir. Bu çalışmada özel bir hastanenin röntgen servisinin
maliyetleri Faaliyet Tabanlı Maliyet Sistemi ve Geleneksel Maliyetleme sistemi yöntemleriyle
hesaplanmıştır. Her iki sistem karşılaştırılarak sunulan hizmetlerdeki birim
maliyet farklılıkları ortaya konulmuştur. Bu çalışma sonucunda her hizmetin
maliyetinin doğru hesaplanmasıyla doğru fiyatlandırması amaçlanmıştır. Yapılan karşılaştırmalar neticesinde FTM
sisteminin daha gerçekçi maliyetler ortaya koyduğu görülmüştür.
Analysis of response of vitiligo to treatment with NBUVB
Authors: Madhava Praveen J. , Sidhwa Jatin 
Published: December 2018

<p class="abstract"><strong>Background:</strong> Vitiligo is an acquired skin disorder characterised by white (depigmented) patches in the skin, due to the loss of functioning melanocytes. The disease can have devastating consequences on an individual’s relationships with others and internal feelings of self-worth. Vitiligo is caused by a dynamic interplay between genetic and environmental risks that initiates an autoimmune attack on melanocytes in the skin. Long term phototherapy has shown good response in the management of vitiligo. In this study we explore the efficacy of phototherapy in management of our vitiligo patients.</p><p class="abstract"><strong>Methods:</strong> 30 subjects were included in the study. Subjects were started on NBUVB at 300mj/cm<sup>2</sup>. Weekly 3 doses were given. Doses were increased after every 3<sup>rd</sup> sitting by 10%. In case of adverse effects treatment is withheld till resolution of symptoms following which NBUVB is given at 50% of the last dose and patient managed based on the response.<strong></strong></p><p class="abstract"><strong>Results:</strong> A majority of the subjects showed significant and persistent improvement within the first 3 months of initiation of treatment. The proportion of the patients showing improvement increased with duration of treatment.</p><p class="abstract"><strong>Conclusions:</strong> Our study has revealed the standard and significant role the phototherapy plays in the treatment of vitiligo as a monotherapy or as an adjuvant with other treatment modalities. With good treatment response and minimal side effect incidence, phototherapy is an important treatment modality in the management of vitiligo.</p><p> </p>
STRATEGI PEMBELAJARAN MENYENANGKAN DENGAN KONSEP LEARNING REVOLUTION
Authors: Wahyudi Dedi , Azizah Habibatul 
Published: December 2018

Dalam setiap proses pendidikan, tentu tidak luput dari berbagai kegiatan belajar dan mengajar yang terjadi di dalamnya. Salah satu hal yang menandakan bahwa seorang individu telah melakukan kegiatan pembelajaran adalah terjadinya perubahan baik dari segi tingkah laku maupun pengetahuan pada diri peserta didik baik pada aspek kognitif, afektif maupun psikomotornya. Namun, hal tersebut hanya dapat terjadi apabila proses pembelajaran lancar sesuai dengan keinginan pendidik maupun peserta didik. Kegiatan pembelajaran akan berjalan lancar dan sesuai harapan apabila kegiatan pembelajaran berada dalam keadaan yang menyenangkan serta tidak membuat para siswa tertekan dengan kegiatan belajar tersebut. Selama ini, kegiatan pembelajaran cenderung bersifat monoton dan membosankan. Sehingga mereka tidak mempunyai motivasi dan semangat belajar yang tinggi. Untuk mengatasi permasalahan tersebut, seorang pendidik harus kreatif dengan menerapkan konsep Learning revolution, yang diharapkan mampu membuat suasana belajar menjadi lebih berkesan dan menyenangkan sehingga kualitas pembelajaran akan meningkat. Learning revolution merupakan proses belajar menyenangkan yang tentu sesuai dengan kemauan peserta didik, dengan harapan dapat meningkatkan semangat belajar mereka dan proses pembelajaran akan berjalan lancar sesuai dengan keinginan peserta didik. In any educational process, certainly not escape from a variety of teaching and learning that happens in it. One thing that signifies that an individual has learning activity is the change in terms of both behavior and knowledge on self-learners well on cognitive, affective and psycomotor. However, it can only happen if the learning process smoothly in accordance with the desire of educators and learners. Learning activities will run smoothly and according to expectation when the learning activities in a state of pleasant and not make the depressed student with the learning activities. During this time, the learning activities and to be monotonous and boring. So they do not have the motivation and the spirit of learning. To overcome these problems, an educator must be creative by applying the concept of the learning revolution, which is expected to make learning more memorable and enjyable so that the quality of learning will increase. Learning revolution is a fun learning process that would correspon to the willingness of students, with the hpe of improving their enthusiasm for learning and the learning process will run smoothly in accordance with the wishes of learners. Kata kunci: strategi pembelajaran, pembelajaran menyenangkan, learning revolution
UPAYA MENINGKATKAN HASIL BELAJAR PENDIDIKAN KEWARGANEGARAAN MELALUI PEMBELAJARAN KOOPERATIF MODEL JIGSAW
Authors: Yubaidah Siti 
Published: December 2018

Penelitian ini bertujuan untuk mengetahui bagaimana meningkatkan hasil belajar pendidikan kewarganegaran pada pembelajaran tingkat dasar melalui pembelajaran kooperatif model jigsaw. Penelitian ini dilaksanakan pada Peserta Didik Kelas V Sekolah Dasar (SD) Negeri I Mayong Kidul Jepara Tahun Pelajaran 2015/2016. Jenis penelitian ini adalah penelitian tindakan kelas yang biasanya disebut dengan PTK. Pada penelitian tindakan kelas ini dilakukan dalam dua kali siklus tindakan. Pada penelitian ini peneliti adalah seorang pendidik dalam pelaksanaan proses pembelajaran pendidikan kewarganegaraan. Pada setiap siklus pada penelitian tidakan kelas ini terdiri dari perencanaan, pelaksanaan pembelajaran pendidikan kewarganegaraan, observasi serta refleksi. Selanjutnya subjek pada penelitian ini adalah peserta didik kelas V Sekolah Dasar (SD) Negeri I Mayong Kidul Jepara Tahun 2015/2016 dengan jumlah peserta didiknya adalah 20 orang. This study aims to determine how to improve learning outcomes of citizenship education course at the primary (elementary) level of education in Indonesia through cooperative learning using jigsaw models. The research was conducted involving the students of grade five of Elementary School (SD) I Mayong Kidul Jepara in the academic year of 2015/2016. This research is a classroom action research that is usually called in Indonesian context as penelitian tindakan kelas (PTK). In this classroom action research, the study was conducted in two cycles of action. In this study, the researcher is a teacher-researcher in the implementation process of civic education course. In each cycle of this classroom action research, I conducted several activities such as planning, actuating (implementation) the civic education course, observation and reflection. Furthermore, the subjects in this study were the students of grade five of Elementary School (SD) I Mayong Kidul Jepara Year 2015/2016 with the number of student participants is 20 people. Kata kunci: hasil pembelajaran, pembelajaran kooperatif, model jigsaw