bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of mesh complications following surgery for stress urinary incontinence or pelvic organ prolapse: a systematic review
Authors: Carter P , Fou L , Whiter F , Delgado Nunes V , Hasler E , Austin C , Macbeth F , Ward K , Kearney R 
Published: September 2019

BackgroundMesh surgery for stress urinary incontinence or pelvic organ prolapse can result in complications such as mesh exposure, mesh extrusion, voiding dysfunction, dyspareunia, and pain. There is limited knowledge or guidance on the effective management for mesh‐related complications.ObjectiveTo determine the best management of mesh complications; a systematic review was conducted as part of the national clinical guideline ‘Urinary incontinence (update) and pelvic organ prolapse in women: management’.Search strategySearch strategies were developed for each indication for referral.Selection criteriaRelevant interventions included complete or partial mesh removal, mesh division, and non‐surgical treatments such as vaginal estrogen.Data collection and analysisCharacteristics and outcome data were extracted, and as a result of the heterogeneous nature of the data a narrative synthesis was conducted.Main resultsTwenty‐four studies were included; five provided comparative data and four studies stated the indication for referral. Reported outcomes (including pain, dyspareunia, satisfaction, quality of life, incontinence, mesh exposure, and recurrence) and the reported incidences of these varied widely.ConclusionsThe current evidence base is limited in quantity and quality and does not permit firm recommendations to be made on the most effective management for mesh‐related complications. Robust data are needed so that mesh complications can be managed effectively in the future.Tweetable abstractSystematic review demonstrates that the outcomes following mesh revision surgery are highly variable.
Prevalence of risk—drinking in critically ill patients, screened with carbohydrate‐deficient transferrin and AUDIT‐C score: A retrospective study
Authors: Uljas Eliisa , Jalkanen Ville , Kuitunen Anne , Hynninen Marja , Hästbacka Johanna 
Published: September 2019

BackgroundStudies demonstrate that up to one‐third of intensive care unit (ICU) admissions are directly or indirectly related to alcohol. Screening for alcohol use is not routine. This study examined the prevalence of elevated %CDT (carbohydrate‐deficient transferrin) and above risk‐level AUDIT‐C (Alcohol Use Disorders Identification Test, Consumption) in patients admitted to ICU.MethodsWe conducted a retrospective analysis of clinical and laboratory data from a single ICU where %CDT and AUDIT‐C were included in routine assessment. After excluding readmissions, 2532 adult patients from a 21‐month period were included. Admission values of %CDT were available for 2049 patients, and AUDIT‐C was available for 1617 patients. The association of %CDT and AUDIT‐C with short‐ and long‐term outcome was studied by using univariate and multivariate logistic regression analysis.Results%CDT was above the reference value in 23.7% (486/2048) of patients with available %CDT. Of patients with available AUDIT‐C, 33% (544/1617) had a risk‐level AUDIT‐C score. Patients with a risk‐level AUDIT‐C score were significantly younger than those with a lower score (51 vs 64 years, P < .0001). Increased %CDT was associated with higher severity of illness. AUDIT‐C was associated independently with increased risk of long‐term mortality in multivariate analysis (P = .007).ConclusionOne in three of ICU patients are risk‐level alcohol users as measured with AUDIT‐C score, and one in four are analysed with %CDT. The prevalence varies according to the method used and any method alone may be insufficient to detect risk‐level consumption reliably.
Editorial CommentAlcohol overconsumption is associated with need for ICU admission and with less favorable outcomes. Diagnosis of alcohol overconsumption though is problematic due to low sensitivity in screening. In a pilot study, a biomarker and a screening tool are compared. The finding is that multiple tools are needed to achieve an adequate sensitivity for detection.
Abnormal returns and asymmetric information surrounding strategic and financial acquisitions
Authors: Osborne Sarah 
Published: September 2019

AbstractUsing takeover bids from the United States, we investigate the importance of information asymmetry in self‐selection when evaluating the abnormal returns of financial versus strategic takeover targets during a period of possible informed trade. Sample selection bias due to differences in financial versus strategic takeover bid information environments is controlled for using Heckman's model. Results show that takeover announcements are not randomised, indicative of timed announcements, and further that private equity firms exhibit lower price impact post‐announcement. We conclude that the long‐term financial motive of private equity takeovers, coupled with higher private information pre‐announcement, leads to lower abnormal returns post‐announcement.
Depletion of DNA damage binding protein 2 sensitizes triple‐negative breast cancer cells to poly ADP‐ribose polymerase inhibition by destabilizing Rad51
Authors: Zhao Lin , Si Cheng‐Shuai , Yu Yue , Lu Jian‐Wei , Zhuang Yan 
Published: September 2019

AbstractPoly ADP‐ribose polymerase inhibitors (PARPi) have shown promising therapeutic efficacy in triple‐negative breast cancer (TNBC) patients. However, resistance ultimately develops, preventing a curative effect from being attained. Extensive investigations have indicated the diversity in the mechanisms underlying the PARPi sensitivity of breast cancer. In this study, we found that DNA damage binding protein 2 (DDB2), a DNA damage‐recognition factor, could protect TNBC cells from PARPi by regulating DNA double‐strand break repair through the homologous recombination pathway, whereas the depletion of DDB2 sensitizes TNBC cells to PARPi. Furthermore, we found that DDB2 was able to stabilize Rad51 by physical association and disrupting its ubiquitination pathway‐induced proteasomal degradation. These findings highlight an essential role of DDB2 in modulating homologous recombination pathway activity and suggest a promising therapeutic target for TNBC.
Children Learn From Both Embodied and Passive Pretense: A Replication and Extension
Authors: Thompson Brittany N. , Goldstein Thalia R. 
Published: September 2019

Research suggests that children can learn new information via pretense. However, a fundamental problem with existing studies is that children are passive receivers of the pretense rather than active, engaged participants. This preregistered study replicates previous learning from pretense findings (Sutherland & Friedman, 2012, Child Development), in which children are passive observers of pretense, and extends to two additional conditions that require children to partially (with puppets) or fully (with costumes) embody a character. Children (N = 144, 24–79 months) learned equally well, and better than those in the control condition, from all three play scenarios. At a 2‐week follow‐up, learning was equally retained across embodiment conditions for older, but not younger, preschoolers. Future research should consider embodiment’s role for more complex material.
Homologous tropomyosins from vertebrate and invertebrate: Recombinant calibrator proteins in functional biological assays for tropomyosin allergenicity assessment of novel animal foods
Authors: Klueber Julia , Costa Joana , Randow Stefanie , Codreanu‐Morel Françoise , Verhoeckx Kitty , Bindslev‐Jensen Carsten , Ollert Markus , Hoffmann‐Sommergruber Karin , Morisset Martine , Holzhauser Thomas , Kuehn Annette 
Published: September 2019

AbstractBackgroundNovel foods may provide new protein sources for a growing world population but entail risks of unexpected food‐allergic reactions. No guidance on allergenicity assessment of novel foods exists, while for genetically modified (GM) crops it includes comparison of sequence identity with known allergens, digestibility tests and IgE serum screening.ObjectiveAs a proof of concept, to evaluate non‐/allergenic tropomyosins (TMs) regarding their potential as new calibrator proteins in functional biological in vitro assays for the semi‐quantitative allergy risk assessment of novel TM‐containing animal foods with mealworm TM as an example.MethodsPurified TMs (shrimp, Penaeus monodon; chicken Gallus gallus; E coli overexpression) were compared by protein sequencing, circular dichroism analysis and in vitro digestion. IgE binding was quantified using shrimp‐allergic patients' sera (ELISA). Biological activities were investigated (skin testing; titrated basophil activation tests, BAT), compared to titrated biological mediator release using humanized rat basophil leukaemia (RBL) cells.ResultsShrimp and chicken TMs showed high sequence homology, both alpha‐helical structures and thermal stability. Shrimp TM was stable during in vitro gastric digestion, chicken TM degraded quickly. Both TMs bound specific IgE from shrimp‐allergic patients (significantly higher for shrimp TM), whereas skin reactivity was mostly positive with only shrimp TM. BAT and RBL cell assays were positive with shrimp and chicken TM, although at up to 100‐ to 1000‐times lower allergen concentrations for shrimp than chicken TM. In RBL cell assays using both TM as calibrators, an activation of effector cells by mealworm TM similar to that by shrimp TM confirmed the already reported high allergenic potency of mealworm TM as a novel protein source.Conclusions & clinical relevanceAccording to current GM crops' allergenicity assessment, non‐allergenic chicken TM could falsely be considered an allergen on a weight‐of‐evidence approach. However, calibrating allergenic potency in functional BAT and RBL cell assays with clinically validated TMs allowed for semi‐quantitative discrimination of novel food protein's allergenicity. With TM calibration as a proof of concept, similar systems of homologous protein might be developed to scale on an axis of allergenicity.
A cohort study on short mini‐implants for mandibular overdentures compared to those of standard length
Authors: Kovačić Ines , Peršić Sanja , Kranjčić Josip , Čelebić Asja 
Published: September 2019

AbstractObjectivesTo assess peri‐implant bone level, survival and success rates of short (6 or 8 mm long) one‐piece mini‐implants (MDIs) in edentulous patients with extremely resorbed alveolar ridge (interforaminal height <10 mm) rehabilitated with mandibular implant overdentures and to compare them with patients having standard length MDIs in 1‐year prospective clinical study.Material and methodsThe Short MDI group consisted of 28 participants with interforaminal height ≤10 mm. Implants being, both, short and slim (short MDIs: 6 or 8 mm long, 2 or 2.5 mm wide) were inserted. The Standard‐MDI group included 35 participants (interforaminal height >13 mm) who received standard length MDIs (10–14 mm long, 2 or 2.5 mm wide). Primary outcomes were assessments of MDI peri‐implant bone level, survival and success rates; secondary outcomes were assessments of peri‐implant tissue, oral hygiene, and prosthodontic maintenance.ResultsThe Short MDI group had mean marginal bone loss (MBL) of 0.26 ± 0.35 mm, 6.4% of failure, and 92.6% of, both, success and survival rates. The Standard‐MDI group had mean MBL of 0.34 ± 0.40 mm, 5% of failure, 95% of survival, and 94.3% success. There were no significant differences in MBL (p = .420), survival (p = .414), and success (p = .571) between the groups. The Short MDI group had significantly less plaque (p = .001) and bleeding on probing (p < .001).ConclusionWithin the limitations of this study, short MDIs (6 or 8 mm long) in extremely atrophied mandibles (interforaminal height <10 mm) showed good clinical results in the first year of function.
Single‐staged implant placement using the bone ring technique with and without membrane placement: Micro‐CT analysis in a preclinical in vivo study
Authors: Nakahara Ken , Haga‐Tsujimura Maiko , Igarashi Kensuke , Kobayashi Eizaburo , Schaller Benoit , Lang Niklaus P. , Saulacic Nikola 
Published: September 2019

AbstractObjectivesTo assess the impact of collagen membrane application on bone formation surrounding implants placed simultaneously with the bone ring technique.Material and methodsDental implants were inserted simultaneously with the bone ring technique in standardized, vertical alveolar bony defects in the mandible of dogs. On one side of the mandible, the augmented sites were covered with a collagen membrane (M‐Group). On the contralateral side, no membranes were used (NM‐Group). Implants were left to heal with osseointegration for three and six months. The harvested samples were analyzed by means of micro‐CT.ResultsA nonparametric analysis of data revealed that the membranes were not a significant negative factor for bone volume (BV), but for bone‐to‐implant contact (BIC, p = .04). Absence of healing caps impaired BV (p = .04) and BIC (p = .02) as well. Furthermore, loss of healing caps and exposure to the oral environment significantly and negatively affected BV (p < .001) and bone mineral density (p < .05) within 2 mm below the implant shoulder. Implant exposure and healing time had a negative interaction effect on both BV (p = .01) and BIC (p = .01).ConclusionsWithin its limitations, the present study revealed no benefit of membrane application to implant placement simultaneous with the bone ring technique. Disruption of soft tissue healing was identified as a risk factor for decrease in BV and BIC.
Rate of colorectal neoplasia in patients with Hodgkin lymphoma
Authors: Abu‐Sbeih H. , Ali F. S. , Tang T. , Coronel E. , Lee H. J. , Pande M. , Bresalier R. S. , Raju G. S. , Wang Y. 
Published: September 2019

Abstract
Aim
Survivors of Hodgkin lymphoma (HL) are at increased risk of breast, lung, thyroid, stomach, pancreatic and colon cancer. There is limited information on the utility of endoscopic screening for colon cancer. We aimed to describe the adenoma detection rate (ADR) in patients with HL to determine the appropriate timing of colonoscopy screening.
Method
We retrospectively studied patients with HL who underwent colonoscopy between 2000 and 2017.
Results
A total of 251 patients underwent colonoscopy. Eighty (32%) patients had 151 colonic polyps. Thirty per cent of the polyps exhibited high‐grade dysplasia, and invasive colon adenocarcinoma was found in 10 patients. Patients with the nodular sclerosing subtype of HL had a significantly lower ADR than others (P = 0.002). The ADR was 5% in patients younger than 35 years (n = 64), 23% in patients between 35 and 40 years of age (n = 22), 39% in patients between 40 and 50 years of age (n = 51) and 46% in patients older than 50 years (n = 114).
Therapeutic living donor nephrectomy
Authors: Dale Leigh‐Anne , Silva Mark V. , Sandoval Pedro Rodrigo , Decastro Joel , Campenot Eric S. , Ratner Lloyd E. 
Published: September 2019

AbstractTherapeutic living donor nephrectomy is defined as a nephrectomy that is performed as therapy for an underlying medical condition. The patient directly benefits from having their kidney removed, but the kidney is deemed transplantable. The kidney is subsequently used as an allograft for an individual with advanced renal disease. Therapeutic donor nephrectomy can be successfully utilized for a heterogenous cohort of disease processes as both treatment for the donor and to increase the number of suitable organs available for transplantation. We describe four cases of therapeutic donor nephrectomy that were performed at our institution. Of the four cases, two patients elected to undergo therapeutic donor nephrectomy as treatment for loin pain hematuria syndrome; one after blunt abdominal trauma that resulted in complete proximal ureteral avulsion; and the fourth after being diagnosed with a small renal mass. Based on our data presented to the United Network for Organ Sharing Board of Directors (UNOS) in December 2015, living donor evaluation has been made simpler for patients electing to undergo therapeutic donor nephrectomy. UNOS eliminated the requirement for a psychosocial evaluation for these patients. As the organ shortage continues to limit transplantation, therapeutic donor nephrectomy should be considered when appropriate.
Development curves of communication and social interaction in individuals with cerebral palsy
Authors: Tan Siok Swan , van Gorp Marloes , Voorman Jeanine M , Geytenbeek Joke JM , Reinders‐Messelink Heleen A , Ketelaar Marjolijn , Dallmeijer Annet J , Roebroeck Marij E ,   Perrin‐Decade study group
Published: September 2019

AimTo determine development curves of communication and social interaction from childhood into adulthood for individuals with cerebral palsy (CP).MethodThis Pediatric Rehabilitation Research in the Netherlands (PERRIN)‐DECADE study longitudinally assessed 421 individuals with CP, aged from 1 to 20 years at baseline, after 13 years (n=121 at follow‐up). Communication and social interactions were assessed using the Vineland Adaptive Behavior Scales. We estimated the average maximum performance limit (level) and age at which 90% of the limit was reached (age90) using nonlinear mixed‐effects modeling.ResultsOne‐hundred individuals without intellectual disability were aged 21 to 34 years at follow‐up (39 females, 61 males) (mean age [SD] 28y 5mo [3y 11mo]). Limits of individuals without intellectual disability, regardless of Gross Motor Function Classification System (GMFCS) level, approached the maximum score and were significantly higher than those of individuals with intellectual disability. Ages90 ranged between 3 and 4 years for receptive communication, 6 and 7 years for expressive communication and interrelationships, 12 and 16 years for written communication, 13 and 16 years for play and leisure, and 14 and 16 years for coping. Twenty‐one individuals with intellectual disability were between 21 and 27 years at follow‐up (8 females, 13 males) (mean age [SD] 24y 7mo [1y 8mo]). Individuals with intellectual disability in GMFCS level V showed the least favourable development, but variation between individuals with intellectual disability was large.InterpretationIndividuals with CP and without intellectual disability show developmental curves of communication and social interactions similar to typically developing individuals, regardless of their level of motor function. Those with intellectual disability reach lower performance levels and vary largely in individual development.What this paper adds

Communication and social interactions in individuals with cerebral palsy without intellectual disability develop similarly to typically developing individuals.

Communication and social interactions of individuals with intellectual disability develop less favourably and show large variation.
A practical guide to graphic communication for quality assurance, education, and patient care in echocardiography
Authors: Cohen Gerald I. 
Published: September 2019

AbstractGraphic communication (GC) is useful for continuous quality improvement (CQI), education, and patient care when in‐person discussion is not possible because of geographic and schedule constraints. In echocardiography, these constraints can be mitigated by (a) capturing screenshots and device photos or videos and sharing them by email or text message, (b) simultaneous viewing of images on digital displays, and (c) broadcasting the study real time during acquisition to other mobile or stationary devices. Screenshots are useful for CQI and education and can be acquired, annotated, and shared with minimal impact on the flow of clinical echo interpretation. Providers at different locations can employ GC for shared clinical decision making by viewing echo studies from the same server, video conferencing or accessing real‐time broadcast from a device. Which GC tool is selected is determined by its ease of use, the provider's goals and whether immediate image review is needed.
Oral and cranio‐maxillofacial trauma in children and adolescents in an emergency setting at a Brazilian hospital
Authors: Rêgo Isabel Cristina Quaresma , Vilarinho Silvia Marques Martins , Rodrigues Claudia Karolyne Freitas , Correia Paula Vitória de Almeida Ramos , Junqueira José Luiz Cintra , Oliveira Luciana Butini 
Published: September 2019

AbstractBackground/AimsVery few studies have been performed to evaluate cranio‐maxillofacial trauma diagnosed in hospitals in children and adolescents. The aim of this study was to perform an analysis of oral and cranio‐maxillofacial trauma in the aforementioned population.Materials and MethodsA hospital‐based retrospective study, which reviewed 1438 patient records, was conducted at the “Teresina Emergency Hospital”, Brazil. Data regarding demographics, day of the week on which trauma occurred, type of injury, etiology, anatomic trauma site, time of hospital admission, and associated comorbidities (or injuries) were collected.ResultsThere were 1092 (75.9%) males and 346 (24.1%) females. The largest group was adolescents aged between 13 and 18 years (956, 66.5%). The majority lived in urban areas (69%). Trauma occurred most frequently during the week. The most prevalent etiology was road traffic accidents involving motorcycles (771, 53.6%) causing facial and skull fractures (598, 41%). The most prevalent soft tissue lesions were facial abrasions (49%), followed by injuries to the cheek (16.7%). Comorbidities associated with craniofacial trauma were present in 82%, with complications from traumatic brain injuries being the most prevalent (65.6%) Dental trauma was recorded in only 81 cases (5.6%).ConclusionMale adolescents living in urban areas were most affected by craniofacial trauma. The most common cause was road traffic accidents involving motorcycles, resulting in facial and skull fractures. Complications from traumatic brain injuries were the most common associated injuries.
Infection scene investigation of shot holes: Incomplete but neutral abscission of brown spots on oriental cherry leaves
Authors: Park Junhyung , Kim Ki Woo 
Published: September 2019

AbstractShot holes on oriental cherry (Prunus serrulata var. spontanea) leaves were investigated to evaluate their role in the elimination of pathogens using analytical electron microscopy. Small brown spots caused by Mycosphaerella cerasella appeared on the leaf surface and developed into shot holes that were approximately 1–5 mm in diameter. Field emission scanning electron microscopy revealed clusters of fungal conidiophores and hyphal growth on the leaf surface around the shot holes. The fungal structures were mostly located within a radius of 500 μm from the shot holes and confined to the epidermal sector separated by veins. X‐ray microanalysis revealed distinct calcium ring patterns encircling the shot holes. The abscised surfaces consisted of suberized plant cells colonized with filamentous fungi and yeasts. Embedded in the mesophyll tissue, druse crystals were co‐localized with calcium and oxygen. Despite the fungal presence around the shot holes, no further expansion of the shot holes was observed on the leaf surface. These results suggest that shot holes may represent an incomplete but neutral abscission of infection loci in the presence of necrotrophic fungal pathogens. This microscopy study provides insight into the formation and roles of calcium oxalate in plants under pathological conditions.