bluuebunny/crossref_metadata_2025_split huggingface dataset:
Problems of psychophysiological status of human capital in the cyclic conditions of Arctic
Authors: Bashkireva T , Bashkireva A , Severin A , Morozov A 
Published: August 2019

AbstractThe problem of studying the psychophysiological status of labor resources, carrying out their professional activities in the complex cyclical conditions of the Arctic latitudes, is extremely important. The human research and his work activities are being actively developed in various areas of the medical, biological and psychological sciences. However, a systematic study of the psychophysiological status of human capital in the cyclical conditions of the Arctic, using its scientific terminology, has been identified individually. In this connection, it remains unclear whether the mechanism of integral adaptation to the conditions of the complex effect of stress factors of different nature, important for identifying the psycho-physiological status and psychological portrait of human capital in the special cyclical conditions of the Arctic. In the studied literature, we have not encountered a synergistic approach to the problems under study. It should be understood that human resources were not considered as a dissipative system and therefore we see in the results only the principle of determinism, but not the fractal one. The obtained information about the psychophysiological problems of human capital in the cyclical conditions of professional activity is necessary to create areas of medical and environmental monitoring of the Arctic.
Features of color mentality of the indigenous small nationalities of the Arctic (on the example of the analysis of the traditional Khanty people costume)
Authors: Bakieva O A , Popova O A 
Published: August 2019

Abstract
The relevance of the presented research is connected with the problem of preserving the mentality, cultural traditions and way of life of small peoples of the Arctic (using the example of the Khanty). In this regard, the most interesting direction of research for us is the symbolism of color in the culture of these peoples, since the color carried a certain sacred meaning, revealing the features of the ethnic groups living in this region. During the study of the color mentality of the ethnic group, chromatic combinations of the traditional female costume of the Khanty were analyzed. According to the authors, the language of color is a non-verbal means of communication; it serves to understand the mentality by interpreting signs and symbols expressed in traditional costumes, symbolically embodying the cosmological model of traditional society. Based on the psychodiagnosis of Max Lüscher, it was found out how much the color preferences in the art of traditional costume reveal the national peculiarities of character and emotional state. To conduct a comparative analysis, the color criteria system has been developed, including primary colors, colors in ornamental symbols and color accents. The authors study the color symbolism in the costume through ethno-psychology, which allows to make sure that the color mentality of the few indigenous Northern ethnic groups of the Khanty is correct. It follows from this that the color mentality of an ethnos expresses a vital position, value orientations, ideological and behavioral stereotypes based on the peculiarities of the emotional state and psyche, which are characteristic of this ethnic group. Thanks to the study of color mentality in the decorative and applied art of the northern, eastern and southern Khanty, the authors revealed not only the peculiarity of the national character and worldview, but also revealed the distinctive features of this people. In this regard, the most interesting area of research for us is the symbolism of color in the culture of these peoples, as the color carried a certain sacred semantic load, revealing the characteristics of the ethnic groups living in this region.
KRAB ZNF explorer—the online tool for the exploration of the transcriptomic profiles of KRAB-ZNF factors in The Cancer Genome Atlas
Authors: Cylwa Rafał , Kiełczewski Kornel , Machnik Marta , Oleksiewicz Urszula , Biecek Przemysław 
Published: August 2019

Abstract

Summary
Krüppel-associated box domain zinc finger protein (KRAB ZNF) explorer is a web-based tool for comprehensive characterization of the mRNA expression status of KRAB-ZNF transcription factors in the data from The Cancer Genome Atlas study. Key functionalities cover a comparative analysis of KRAB-ZNF expression between normal and cancer tissues, an association of KRAB-ZNF expression with various pathological features, including survival analysis, association with global DNA methylation status, analyses of KRAB-ZNF isoform expressions and analysis of KRAB-ZNF levels in normal tissues.

Availability and implementation
KRAB ZNF explorer is available at http://mi2.mini.pw.edu.pl: 8080/KRAB_ZNF/. The source code for shiny application is available at: https://github.com/MI2DataLab/KRAB_ZNF/tree/master/app and the source code for analyses and precalculations are available at: https://github.com/MI2DataLab/KRAB_ZNF/tree/master/work
CNVRanger: association analysis of CNVs with gene expression and quantitative phenotypes
Authors: da Silva Vinicius , Ramos Marcel , Groenen Martien , Crooijmans Richard , Johansson Anna , Regitano Luciana , Coutinho Luiz , Zimmer Ralf , Waldron Levi , Geistlinger Ludwig 
Published: August 2019

AbstractSummaryCopy number variation (CNV) is a major type of structural genomic variation that is increasingly studied across different species for association with diseases and production traits. Established protocols for experimental detection and computational inference of CNVs from SNP array and next-generation sequencing data are available. We present the CNVRanger R/Bioconductor package which implements a comprehensive toolbox for structured downstream analysis of CNVs. This includes functionality for summarizing individual CNV calls across a population, assessing overlap with functional genomic regions, and genome-wide association analysis with gene expression and quantitative phenotypes.Availability and implementationhttp://bioconductor.org/packages/CNVRanger.
Interindividual variation and consistency of migratory behavior in the Eurasian woodcock
Authors: Tedeschi Alessandro , Sorrenti Michele , Bottazzo Michele , Spagnesi Mario , Telletxea Ibon , Ibàñez Ruben , Tormen Nicola , De Pascalis Federico , Guidolin Laura , Rubolini Diego 
Published: August 2019

Abstract
Diverse spatio-temporal aspects of avian migration rely on relatively rigid endogenous programs. However, flexibility in migratory behavior may allow effective coping with unpredictable variation in ecological conditions that can occur during migration. We aimed at characterizing inter- and intraindividual variation of migratory behavior in a forest-dwelling wader species, the Eurasian woodcock Scolopax rusticola, focusing on spatio-temporal consistency across repeated migration episodes. By satellite-tracking birds from their wintering sites along the Italian peninsula to their breeding areas, we disclosed a remarkable variability in migration distances, with some birds flying more than 6,000 km to Central Asian breeding grounds (up to 101°E). Prebreeding migration was faster and of shorter duration than postbreeding migration. Birds moving over longer distances migrated faster during prebreeding migration, and those breeding at northernmost latitudes left their wintering areas earlier. Moreover, birds making longer migrations departed earlier from their breeding sites. Breeding site fidelity was very high, whereas fidelity to wintering areas increased with age. Migration routes were significantly consistent, both among repeated migration episodes and between pre- and postbreeding migration. Prebreeding migration departure date was not significantly repeatable, whereas arrival date to the breeding areas was highly repeatable. Hence, interindividual variation in migratory behavior of woodcocks was mostly explained by the location of the breeding areas, and spatial consistency was relatively large through the entire annual cycle. Flexibility in prebreeding migration departure date may suggest that environmental effects have a larger influence on temporal than on spatial aspects of migratory behavior.
Antithrombotic therapy and major adverse limb events in patients with chronic lower extremity arterial disease: systematic review and meta-analysis from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy in Collaboration with the European Society of Cardiology Working Group on Aorta and Peripheral Vascular Diseases
Authors: Savarese Gianluigi , Reiner Martin F , Uijl Alicia , D’Amario Domenico , Agewall Stefan , Atar Dan , Baumgartner Iris , Borghi Claudio , De Carlo Marco , Drexel Heinz , Kaski Juan Carlos , Kjeldsen Keld P , Kucher Nils , Lund Lars H , Niessner Alexander , Semb Anne Grete , Schmidt Thomas A , Sulzgruber Patrick , Tamargo Juan , Vitale Cristiana , Wassmann Sven , Aboyans Victor , Lewis Basil S 
Published: August 2019

Abstract

Aims
The role and selection of antithrombotic therapy to improve limb outcomes in chronic lower extremity artery disease (LEAD) is still debated. We conducted a meta-analysis to examine the efficacy and safety of antithrombotic and more intense antithrombotic therapy on limb outcomes and limb salvage in patients with chronic LEAD.

Methods and results
Study inclusion criteria were: enrolment of patients with LEAD, randomized allocation to more vs. less intense antithrombotic therapy [more vs. less intense single-antiplatelet therapy (SAPT); dual-antiplatelet therapy vs. SAPT; dual antithrombotic therapy vs. SAPT or oral anticoagulant]; enrolment of ≥200 patients; reporting of at least one of following outcomes: limb amputation or revascularization. Seven randomized studies enrolling 30 447 patients were included. Over a median follow-up of 24 months, more vs. less intense antithrombotic therapy or placebo significantly reduced the risk of limb revascularization [relative risk (RR) 0.89, 95% confidence interval (CI) 0.83–0.94] and limb amputation (RR 0.63, 95% CI 0.46–0.86), as well as stroke (RR 0.82, 95% CI 0.70–0.97). There was no statistically significant effect on the risk of myocardial infarction (RR 0.98, 95% CI 0.87–1.11), all-cause (RR 0.93, 95% CI 0.86–1.01), and cardiovascular death (RR 0.97, 95% CI 0.86–1.08). Risk of major bleeding increased (RR 1.23, 95% CI 1.04–1.44).

Conclusion
In patients with LEAD, more intense antithrombotic therapy reduces the risk of limb amputation and revascularization as well as stroke with an increase in the risk of bleeding events.
Oral health-related quality of life in orthodontics: a cross-sectional multicentre study on patients in orthodontic treatment
Authors: Paes da Silva Susie , Pitchika Vinay , Baumert Uwe , Wehrbein Heinrich , Schwestka-Polly Rainer , Drescher Dieter , Kühnisch Jan , Wichelhaus Andrea 
Published: August 2019

Summary

Objective
This study aimed to assess oral health-related quality of life (OHRQoL) in relation to associated covariates in orthodontic patients of different age groups (children, adolescents, and adults) in a cross-sectional study.

Methods
A total of 898 subjects (50.6% females, 49.4% males; mean age 16.89 years) undergoing orthodontic treatment anonymously completed the German version of the Oral Health Impact Profile (OHIP-G14) to assess OHRQoL in addition to completing 23 other items. Descriptive, exploratory statistical analysis and multiple linear regression modelling were performed.

Results
The mean score of the OHIP-G14 was 8.3 for the 6- to 11-year olds, 8.9 for the 12- to 17-year olds, and 12.6 for adults. Physical pain (Subscale 2) was the highest factor in all groups. Additionally, a relevant factor was Subscale 3 (psychological discomfort). A linear regression model showed that, in the adolescent group, aesthetics in combination with pain had a significant negative influence on OHRQoL, whereas, in the adult group, function in combination with pain showed the same significant negative influence. Second, except for the children, fixed appliances had a significant negative effect on OHRQoL compared to removable appliances.

Conclusions
Our study showed that the majority of the 6- to 11-year olds and 12- to 17-year olds reported a good OHRQoL. Nevertheless, adolescents and adults who reported aesthetic/pain and function/pain problems, respectively, as reasons for orthodontic treatment showed a significant occurrence for reduced OHRQoL. Fixed appliances, in comparison with removable appliances, also resulted in a significant reduction in OHRQoL for both groups.
Enhanced tomato plant growth in soil under reduced P supply through microbial inoculants and microbiome shifts
Authors: Eltlbany Namis , Baklawa Mohamed , Ding Guo-Chun , Nassal Dinah , Weber Nino , Kandeler Ellen , Neumann Günter , Ludewig Uwe , van Overbeek Leo , Smalla Kornelia 
Published: August 2019

ABSTRACTSoil microbial communities interact with roots, affecting plant growth and nutrient acquisition. In the present study, we aimed to decipher the effects of the inoculants Trichoderma harzianum T-22, Pseudomonas sp. DSMZ 13134, Bacillus amyloliquefaciens FZB42 or Pseudomonas sp. RU47 on the rhizosphere microbial community and their beneficial effects on tomato plants grown in moderately low phosphorous soil under greenhouse conditions. We analyzed the plant mass, inoculant colony forming units and rhizosphere communities on 15, 22, 29 and 43 days after sowing. Selective plating showed that the bacterial inoculants had a good rhizocompetence and accelerated shoot and root growth and nutrient accumulation. 16S rRNA gene fingerprints indicated changes in the rhizosphere bacterial community composition. Amplicon sequencing revealed that rhizosphere bacterial communities from plants treated with bacterial inoculants were more similar to each other and distinct from those of the control and the Trichoderma inoculated plants at harvest time, and numerous dynamic taxa were identified. In conclusion, likely both, inoculants and the rhizosphere microbiome shifts, stimulated early plant growth mainly by improved spatial acquisition of available nutrients via root growth promotion. At harvest, all tomato plants were P-deficient, suggesting a limited contribution of inoculants and the microbiome shifts to the solubilization of sparingly soluble soil P.
BFF: Bayesian, Fiducial, Frequentist Analysis of Age Effects in Daily Diary Data
Authors: Neupert Shevaun D , Hannig Jan 
Published: August 2019

Abstract

Objectives
We apply new statistical models to daily diary data to advance both methodological and conceptual goals. We examine age effects in within-person slopes in daily diary data and introduce Generalized Fiducial Inference (GFI), which provides a compromise between frequentist and Bayesian inference. We use daily stressor exposure data across six domains to generate within-person emotional reactivity slopes with daily negative affect. We test for systematic age differences and similarities in these reactivity slopes, which are inconsistent in previous research.

Method
One hundred and eleven older (aged 60–90) and 108 younger (aged 18–36) adults responded to daily stressor and negative affect questions each day for eight consecutive days, resulting in 1,438 total days. Daily stressor domains included arguments, avoided arguments, work/volunteer stressors, home stressors, network stressors, and health-related stressors.

Results
Using Bayesian, GFI, and frequentist paradigms, we compared results for the six stressor domains with a focus on interpreting age effects in within-person reactivity. Multilevel models suggested null age effects in emotional reactivity across each of the paradigms within the domains of avoided arguments, work/volunteer stressors, home stressors, and health-related stressors. However, the models diverged with respect to null age effects in emotional reactivity to arguments and network stressors.

Discussion
The three paradigms converged on null age effects in reactivity for four of the six stressor domains. GFI is a useful tool that provides additional information when making determinations regarding null age effects in within-person slopes. We provide the code for readers to apply these models to their own data.
Using Lean Six Sigma to improve rates of day of surgery admission in a national thoracic surgery department
Authors: Brown Rachel , Grehan Petra , Brennan Marie , Carter Denise , Brady Aoife , Moore Eoin , Teeling SeÁn Paul , Ward Marie , Eaton Donna 
Published: August 2019

Abstract

Objective
The aim of this study is to improve rates of day of surgery admission (DOSA) for all suitable elective thoracic surgery patients.

Design
Lean Six Sigma (LSS) methods were used to enable improvements to both the operational process and the organizational working of the department over a period of 19 months.

Setting
A national thoracic surgery department in a large teaching hospital in Ireland.

Participants
Thoracic surgery staff, patients and quality improvement staff at the hospital.

Intervention(s)
LSS methods were employed to identify and remove the non-value-add in the patient’s journey and achieve higher levels of DOSA. A pre-surgery checklist and Thoracic Planning Meeting were introduced to support a multidisciplinary approach to enhanced recovery after surgery (ERAS), reduce rework, improve list efficiency and optimize bed management.

Main Outcome Measure(s)
To achieve DOSA for all suitable elective thoracic surgery patients in line with the National Key Performance Indicator of 75%. A secondary outcome would be to further decrease overall length of stay by 1 day.

Results
Over a 19 month period, DOSA has increased from 10 to 75%. Duplication of preoperative tests reduced from 83 to &lt;2%. Staff and patient surveys show increased satisfaction and improved understanding of ERAS.

Conclusions
Using LSS methods to improve both operational process efficiency and organizational clinical processes led to the successful achievement of increasing rates of DOSA in line with national targets.
NuGrid stellar data set – III. Updated low-mass AGB models and s-process nucleosynthesis with metallicities Z= 0.01, Z = 0.02, and Z = 0.03
Authors: Battino U , Tattersall A , Lederer-Woods C , Herwig F , Denissenkov P , Hirschi R , Trappitsch R , den Hartogh J W , Pignatari M ,   (The NuGrid Collaboration†)
Published: August 2019

ABSTRACT
The production of the neutron-capture isotopes beyond iron that we observe today in the Solar system is the result of the combined contribution of the r-process, the s-process, and possibly the i-process. Low-mass asymptotic giant branch (AGB) (1.5 < M/M⊙ < 3) and massive (M > 10 M⊙) stars have been identified as the main site of the s-process. In this work we consider the evolution and nucleosynthesis of low-mass AGB stars. We provide an update of the NuGrid Set models, adopting the same general physics assumptions but using an updated convective-boundary-mixing model accounting for the contribution from internal gravity waves. The combined data set includes the initial masses MZAMS/M⊙ = 2, 3 for Z = 0.03, 0.02, 0.01. These new models are computed with the mesa stellar code and the evolution is followed up to the end of the AGB phase. The nucleosynthesis was calculated for all isotopes in post-processing with the NuGrid mppnp code. The convective-boundary-mixing model leads to the formation of a 13C-pocket three times wider compared to the one obtained in the previous set of models, bringing the simulation results now in closer agreement with observations. Using these new models, we discuss the potential impact of other processes inducing mixing, like rotation, adopting parametric models compatible with theory and observations. Complete yield data tables, derived data products, and online analytic data access are provided.
Targeting reduced mitochondrial DNA quantity as a therapeutic approach in pediatric high-grade gliomas
Authors: Shen Han , Yu Man , Tsoli Maria , Chang Cecilia , Joshi Swapna , Liu Jie , Ryall Scott , Chornenkyy Yevgen , Siddaway Robert , Hawkins Cynthia , Ziegler David S 
Published: August 2019

Abstract

Background
Despite increased understanding of the genetic events underlying pediatric high-grade gliomas (pHGGs), therapeutic progress is static, with poor understanding of nongenomic drivers. We therefore investigated the role of alterations in mitochondrial function and developed an effective combination therapy against pHGGs.

Methods
Mitochondrial DNA (mtDNA) copy number was measured in a cohort of 60 pHGGs. The implication of mtDNA alteration in pHGG tumorigenesis was studied and followed by an efficacy investigation using patient-derived cultures and orthotopic xenografts.

Results
Average mtDNA content was significantly lower in tumors versus normal brains. Decreasing mtDNA copy number in normal human astrocytes led to a markedly increased tumorigenicity in vivo. Depletion of mtDNA in pHGG cells promoted cell migration and invasion and therapeutic resistance. Shifting glucose metabolism from glycolysis to mitochondrial oxidation with the adenosine monophosphate–activated protein kinase activator AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) or the pyruvate dehydrogenase kinase inhibitor dichloroacetate (DCA) significantly inhibited pHGG viability. Using DCA to shift glucose metabolism to mitochondrial oxidation and then metformin to simultaneously target mitochondrial function disrupted energy homeostasis of tumor cells, increasing DNA damage and apoptosis. The triple combination with radiation therapy, DCA and metformin led to a more potent therapeutic effect in vitro and in vivo.

Conclusions
Our results suggest metabolic alterations as an onco-requisite factor of pHGG tumorigenesis. Targeting reduced mtDNA quantity represents a promising therapeutic strategy for pHGG.
Use of Polyvinyl Alcohol Sponge Cubes for Vagal Nerve Stimulation: A Suggestion for the Wrapping Step. Technical Note and Step-by-Step Operative Technique
Authors: Hamdi Hussein , Spatola Giorgio , Lagarde Stanislas , McGonigal Aileen , Paz-Paredes Armando , Bizeau Alain , Bartolomei Fabrice , Carron Romain 
Published: August 2019

Abstract

BACKGROUND
Vagal nerve stimulation (VNS) is an approved treatment for epilepsy and depression. Wrapping the helical electrodes around the nerve can prove technically challenging. However, a quick and efficient method to slightly elevate the nerve can highly facilitate this part of the procedure.

OBJECTIVE
To provide useful surgical tips to facilitate the procedure.

METHODS
Based on experience of more than 150 adult cases for mainly epilepsy (primary lead implant), the authors share their surgical technique to provide the experienced surgeons or newcomers to the field of VNS with some useful tips. All patients signed informed consent according to the local ethics committee guidelines.

RESULTS
The article consists of a detailed step-by-step description of the whole procedure illustrated through high-resolution colored photographs of the surgical field. Special reference is made to the usefulness of polyvinyl alcohol (PVA) sponge cubes to elevate the nerve instead of the commonly used silicon vessel loops.

CONCLUSION
The use of surgical microscope and PVA sponge cubes to elevate the nerve constitute key points to make VNS an easy surgery.