bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipid associated polygenic enrichment in Alzheimer’s disease
Authors: Broce Iris J. , Tan Chin Hong , Fan Chun Chieh , Witoelar Aree , Wen Natalie , Jansen Iris , Hess Christopher P. , Dillon William P. , Glastonbury Christine M. , Glymour Maria , Yokoyama Jennifer S. , Elahi Fanny M. , Rabinovici Gil D. , Miller Bruce L. , Mormino Elizabeth C. , Sperling Reisa A. , Bennett David A , McEvoy Linda K. , Brewer James B. , Feldman Howard A. , Posthuma Danielle , Hyman Bradley T. , Schellenberg Gerard S. , Yaffe Kristine , Andreassen Ole A. , Dale Anders M. , Sugrue Leo P. , Karch Celeste M. , Desikan Rahul S. 
Published: August 2018

ABSTRACTCardiovascular (CV) and lifestyle associated risk factors (RFs) are increasingly recognized as important for Alzheimer’s disease (AD) pathogenesis. Beyond the ∊4 allele of apolipoprotein E (APOE), comparatively little is known about whether CV associated genes also increase risk for AD (genetic pleiotropy). Using large genome-wide association studies (GWASs) (total n > 500,000 cases and controls) and validated tools to quantify genetic pleiotropy, we systematically identified single nucleotide polymorphisms (SNPs) jointly associated with AD and one or more CV RFs, namely body mass index (BMI), type 2 diabetes (T2D), coronary artery disease (CAD), waist hip ratio (WHR), total cholesterol (TC), low-density (LDL) and high-density lipoprotein (HDL). In fold enrichment plots, we observed robust genetic enrichment in AD as a function of plasma lipids (TC, LDL, and HDL); we found minimal AD genetic enrichment conditional on BMI, T2D, CAD, and WHR. Beyond APOE, at conjunction FDR < 0.05 we identified 57 SNPs on 19 different chromosomes that were jointly associated with AD and CV outcomes including APOA4, ABCA1, ABCG5, LIPG, and MTCH2/SPI1. We found that common genetic variants influencing AD are associated with multiple CV RFs, at times with a different directionality of effect. Expression of these AD/CV pleiotropic genes was enriched for lipid metabolism processes, over-represented within astrocytes and vascular structures, highly co-expressed, and differentially altered within AD brains. Beyond APOE, we show that the polygenic component of AD is enriched for lipid associated RFs. Rather than a single causal link between genetic loci, RF and the outcome, we found that common genetic variants influencing AD are associated with multiple CV RFs. Our collective findings suggest that a network of genes involved in lipid biology also influence Alzheimer’s risk.
Ankyrin domain encoding genes resulting from an ancient horizontal transfer are functionally integrated into developmental gene regulatory networks in the waspNasonia
Authors: Pers Daniel , Lynch Jeremy A. 
Published: August 2018

ABSTRACTBackgroundHow and why regulatory networks incorporate additional components, and how novel genes are maintained and functionally integrated into developmental processes are two important and intertwined questions whose answers have major implications for the evolution of development. We recently described a set of novel genes with robust and unique expression patterns along the dorsal-ventral axis of the embryo of the waspNasonia.Given the unique evolutionary history of these genes, and their apparent integration in to the dorsal-ventral (DV) patterning network, they are collectively an excellent model to study the evolution of regulatory networks, and the fates of novel genes.ResultsWe have found that the novel DV genes are part of a large family of rapidly duplicating and diverging ankyrin domain encoding genes that originated most likely by horizontal transfer fromWolbachiain a common ancestor of the wasp superfamilly Chalcidoidea. We tested the function of those ankyrin encoding genes expressed along the DV axis and found that they participate in early embryonic DV patterning. We also developed a new wasp model system(Melittobia)and found that some functional integration of ankyrin genes have been preserved for over 90 million years, while others are lineage specific.ConclusionsOur results indicate that regulatory networks can incorporate novel genes that then become necessary for stable and repeatable outputs. Even modest role in developmental networks may be enough to allow novel or duplicate genes to be maintained in the genome and become fully integrated network components.
Fine-mapping cis-regulatory variants in diverse human populations
Authors: Tehranchi Ashley K. , Hie Brian , Dacre Michael , Kaplow Irene M. , Pettie Kade P , Combs Peter A. , Fraser Hunter B. 
Published: August 2018

AbstractGenome-wide association studies (GWAS) are a powerful approach for connecting genotype to phenotype. Most GWAS hits are located in cis-regulatory regions, but the underlying causal variants and their molecular mechanisms remain unknown. To better understand human cis-regulatory variation, we mapped quantitative trait loci for chromatin accessibility (caQTLs)—a key step in cis-regulation—in 1000 individuals from 10 diverse populations. Most caQTLs were shared across populations, allowing us to leverage the genetic diversity to fine-map candidate causal regulatory variants, several thousand of which have been previously implicated in GWAS. In addition, many caQTLs that affect the expression of distal genes also alter the landscape of long-range chromosomal interactions, suggesting a mechanism for long-range expression QTLs. In sum, our results show that molecular QTL mapping integrated across diverse populations provides a high-resolution view of how worldwide human genetic variation affects chromatin accessibility, gene expression, and phenotype.
Structural capture of an intermediate transport state of a CLC CI-/H+ antiporter
Authors: Park Kunwoong , Lim Hyun-Ho 
Published: August 2018

AbstractThe CLC family proteins are involved in a variety of cellular processes, where chloride homeostasis needs to be controlled. Two distinct classes of CLC proteins, Cl- channels and Cl-/H+ antiporters, have been functionally and structurally investigated over the last several decades. Recent studies have revealed that the conformational heterogeneity of the critical glutamate residue, Gluex could explain the transport cycle of CLC-type Cl-/H+ antiporters. However, the presence of multiple conformations of the Gluex has been suggested from combined structural snapshots of two different CLC antiporters. Thus, we aimed to investigate the presence of these three intermediate conformations in CLC-ec1, the most deeply studied CLC at both functional and structural levels. By comparing crystal structures of E148D, E148A mutant and wildtype CLC-ec1 with varying anion concentrations, we suggest that the Gluex indeed take at least three distinct conformational states in a single CLC antiporter, CLC-ec1.
The limiting DNA replication initiation factors Sld2 and Sld3 influence origin efficiency independent of origin firing time
Authors: Lynch Kelsey L. , Kwan Elizabeth X. , Alvino Gina M. , Brewer Bonita J. , Raghuraman M.K. 
Published: August 2018

AbstractChromosome replication inSaccharomyces cerevisiaeis initiated from roughly 300 origins that are regulated both by DNA sequence and by the limited abundance of fourtrans-actinginitiation proteins (Sld2, Sld3, Dpb11 and Dbf4, collectively called “SSDD”). We set out to determine how the association of Sld2 or Sld3 at origins contributes to time of origin activation and/or origin efficiency using auxin-induced protein degradation to further decrease their abundance. Depleting cells of either factor slows growth rate, increases S-phase duration, and causes viability defects, without activating the S phase checkpoint. Chr XII is uniquely unstable with breakage occurring specifically within the rDNA locus. The efficiency of the rDNA origin is decreased while the onset of replication initiation is unchanged. We found that origin efficiency is reduced uniformly across the unique portions of the yeast genome. We conclude that the abundance of Sld2 and Sld3 contribute primarily to origin efficiency.
Differences in audit pricing between voluntary and mandatory audits
Authors: Gandía Juan L. , Huguet David 
Published: August 2018

PurposeDespite the extensive research on the determinants of audit pricing in both public and private settings, there is a lack of research about the differences in audit fees between voluntary audits and mandatory audits. The purpose of this paper is to address this gap.Design/methodology/approachFirst, a theoretical framework is developed to justify differences in audit pricing between voluntary and mandatory audits. Next, using a sample of Spanish private small and medium enterprises (SMEs) running from 2009 to 2014, the authors empirically test whether the fees charged for voluntary audits differ from those charged for mandatory ones. The authors also examine whether the premium observed among large auditors is persistent in the SME setting, and whether this premium differs depending on whether the audits are voluntary or mandatory.FindingsAlthough a preliminary analysis does not report significant differences in pricing between voluntary and mandatory audits, additional analyses using samples restricted by company size show that voluntary audits are charged with a premium. The authors observe a premium related to large auditors, and find no significant differences in the audit pricing of Big 4 auditors depending on the mandatory/voluntary nature of the audit, but the premium associated with Middle-Tier auditors disappears in the voluntary setting.Originality/valueThis paper contributes to the previous literature by introducing the examination of differences in audit pricing between voluntary and mandatory audits. As far as the authors know, this is the first study to examine the differences in audit pricing between voluntary and mandatory audits. It also elaborates on studies on audit pricing in SMEs.
Lost in translation? Cross-language thematic analysis in tourism and hospitality research
Authors: Esfehani Minoo H. , Walters Trudie 
Published: August 2018

Purpose
Tourism and hospitality research is frequently cross language in nature; yet, English is the most used language to disseminate research findings. The use of thematic analysis is increasing; yet, critical discussions of the implications of the timing of translation when applying this method are rare. The purpose of this study is to present a model for bilingual researchers undertaking qualitative studies in their mother language who are reliant on their own language skills to translate and overcome language differences, and who are using thematic analysis.

Design/methodology/approach
Thematic analysis is a six-phase iterative analysis process during which the main themes are identified and a network of related themes is constructed to facilitate the interpretation of the material. The model is illustrated through reference to a research project carried out by the first author on the role and manifestation of intangible cultural heritage in tourism in protected areas in Iran.

Findings
The model introduces translation as an internal procedure within thematic analysis, situating it between the second and third phases when the codes are being consolidated into basic themes. Translation is viewed as a part of the iterative process of thematic analysis.

Originality/value
This model is the first to provide bilingual cross-language researchers with a practical and epistemologically, methodologically and ethically sound rationale for the timing of translation when using thematic analysis. While it was developed on a tourism case study, the authors believe it is applicable to research in other disciplines where cross-language qualitative analysis is used.
Medical education governance based on strategic planning
Authors: Nurakynova Sabina 
Published: August 2018

Purpose
The purpose of this paper is to analyze the medical education strategic planning to align with international best practices in university governance.

Design/methodology/approach
Research methods used: content analysis, analysis of modern concepts of strategic planning in universities. The study used two main methodological approaches: analysis of medical education governance and analysis of strategic planning in universities.

Findings
Applied models of educational governance at most universities are not always effective in achieving their goals. A strategy is a complex and potentially powerful tool, with the help of which a modern university can withstand the constantly changing environment. By using such a tool, the university can gain prestige, leading positions and recognition in international scientific and educational spheres. Therefore, strategy and strategic planning deserve close attention as a higher education governance tool, suitable not only for a medical college but also for a wide range of other types of social organizations.

Originality/value
Education is a policy priority of any state determining the state’s level of modern socio-economic development and building a productive workforce. The quality of human resources primarily depends on the system of higher education, which is carried out by universities. Foreign countries’ experience shows that prosperity of the state and society is impossible without a healthy nation. Improving the quality of people’s lives depends, in particular, on health education, so “medical education governance” is how we prepare personnel, which must be properly trained and qualified to provide high-quality health care services. Kazakhstan medical universities are increasingly becoming players in the medical education market, but the governance systems of universities are lagging behind. The success of universities largely depends on the results of their strategic planning, which is why special attention should be given to strategic planning analysis. Despite the importance of analyzing medical education governance, there has been insufficient research in this area in Kazakhstan.
A study on performance of slot entry hybrid journal bearing considering effect of surface irregularities
Authors: Sahu Krishnkant , Sharma Satish C. 
Published: August 2018

Purpose
This study aims to deal with the performance of symmetric/asymmetric slot entry hybrid journal bearing system considering the effect of three dimensional irregularities in the analysis.

Design/methodology/approach
The asperity profile of three-dimensional irregularities has been modeled in both circumferential and axial directions. To compute the bearing performance characteristics parameter, finite element formulation of governing Reynolds equation has been derived using Galerkin’s technique.

Findings
Based on the numerically simulated results, it has been observed that the three-dimensional irregularities enhance the value of minimum fluid film thickness (h̄min), lubricant flow (Q̄) and fluid film damping coefficients (C̄11,C̄22) approximately by order of magnitude of 24-26, 43-51 and 18-66 per cent, respectively, for the case of asymmetric slot entry configuration. Whereas, the values of fluid film stiffness coefficients (S̄11,S̄22) and threshold speed (ω̄th) reduces approximately by order of 1-6 and 0-3 per cent, respectively, for the case of symmetric slot entry configuration.

Originality/value
The present paper describes that the influence of three-dimensional irregularities on bearing surface on the performance of slot entry hybrid journal bearing is original in literature gaps. The numerically simulated results presented in this study are expected to be quite useful to the bearing designers.
Designing web-scale discovery systems using the VuFind open source software
Authors: Roy Bijan Kumar , Biswas Subal Chandra , Mukhopadhyay Parthasarathi 
Published: August 2018

PurposeThis paper aims to provide an overview of the emergence of resource discovery systems and services along with their advantages and best practices including current landscapes. It reports the development of a resource discovery system by using the “VuFind” software and describes other technological tools, software, standards and protocols required for the development of the prototype.Design/methodology/approachThis paper describes the process of integrating VuFind (resource discovery tool) with Koha (integrated library system), DSpace (repository software) and Apache Tika (as full-text extractor for full-text searching), etc.FindingsThe proposed model performs like other existing commercial and open source Web-scale resource discovery systems and is capable of harvesting resources from different subscribed or external sources replacing a library’s OPAC.Originality/valueThis discovery system is an important add-on to designing a one-stop access in place of the existing retrieval silos in libraries. This system is capable of indexing a variety of content within and beyond library collections. This work may help library professionals and administrators in designing their discovery system, as well as vendors to improve their products, to provide different library-friendly services.
A practitioner’s guide to the design of strategy map frameworks
Authors: Islam Syrus 
Published: August 2018

PurposeThe purpose of this study is to synthesise the prior literature on strategy maps to develop a practitioner’s guide to the design of strategy map frameworks. Robert Kaplan and David Norton introduced the strategy map in their 2000 Harvard Business review article. A strategy map visually represents how the critical elements of an organisation’s strategies are linked together. In an organisation’s strategy execution process, a strategy map complements a performance measurement framework such as the balanced scorecard.Design/methodology/approachThis is a technical paper, which primarily builds on the prior literature on the strategy map design. In particular, this study reviews 41 publications on strategy maps in the period 2000-2015, including observation of 333 strategy map frameworks.FindingsThis study develops 14 design principles across seven features of a strategy map framework. This study also identifies a significant lack of empirical research on strategy map design features and principles.Research limitations/implicationsFuture research could examine whether and why various design features and principles could exert different or same effects (e.g. decision-relevance).Practical implicationsThe developed design features and principles can be used by practitioners as guidance for developing customised strategy maps for their organisations.Originality/valueThis paper contributes to the literature by serving as a “one-stop shop” for both practitioners and researchers seeking a comprehensive understanding of the current state of the strategy map design features and principles.
Social studies and beyond: attending to informal citizenship education in schools
Authors: Kissling Mark T. 
Published: August 2018

Purpose
Although social studies teachers are charged with explicitly teaching about citizenship, all teachers in a school implicitly teach about citizenship. That is, in their daily interactions with students, whether specific to subject area content or not, teachers impart lessons to their students about what citizenship is and what it means to be a citizen. The paper aims to discuss these issues.

Design/methodology/approach
Examining the “powerful” stories of three teachers, only one of whom teaches social studies, this paper focuses on “informal citizenship education” across schools.

Findings
It concludes with implications for workers in and beyond the field of social studies education.

Originality/value
Ultimately, it suggests that as notions of citizenship education expand to include informal citizenship education, teachers will better teach students to be effective citizens.
The elephant in the classroom: a comparative study of civics end-of-course assessment
Authors: Furgione Brian , Evans Kelsey , Walker Irenea , Russell III William B. 
Published: August 2018

Purpose
Over the last 40 years, K-12 education has seen a continuous and significant increase in the amount of mandated standardized testing. This rise in standardized testing has led many in the field to question the extent to which these tests are affecting students, teachers and schools. The purpose of this paper is to explore the results of a social studies standardized test, specifically, the Florida Civics End-of-Course assessment.

Design/methodology/approach
Researchers used population data for seventh grade students and aggregated countywide proficiency rates from 2013–2016 for comparative statistical measures. Descriptive statistics and regression analyses were utilized to identify emerging trends using mean proficiency percentages when accounting for race, gender and socioeconomic status.

Findings
Initial findings indicated disparity within each subgroup (R2=0.511 (2013–2014), 0.500 (2014–2015) and 0.456 (2015–2016)). Following an analysis of the results, the conclusion and implications discuss the influence of standardized testing in social studies education.

Originality/value
This is a large-scale project that has never been done.
Safety and efficacy of zotarolimus‐eluting stents in the treatment of diabetic coronary lesions in Chinese patients: The RESOLUTE‐DIABETES CHINA Study
Authors: Zhu Zhengbin , Wu Yongjian , Shen Zhujun , Xu Yawei , Li Yigang , Wang Yan , Su Xi , Li Bao , Jiang Tiemin , Jiang Jinfa , Wang Lefeng , He Shenghu , Li Xueqi , Li Hongwei , Liu Yin , Zhou Yujie , Tang Qiang , Chen Yundai , Fang Weiyi , Jiang Li , Lu Chengzhi , Guo Jincheng , Zhang Jianjun , Chen Shaoliang , Xia Yong , Zheng Hongchao , Wang Bin , Zhang Daifu , Feng Liuliu , Tang Lijiang , Xu Peng , Liu Xuebo , Zhang Ruiyan ,   on behalf of the RESOLUTE‐DIABETES CHINA Investigators
Published: August 2018

AbstractBackgroundThe RESOLUTE‐DIABETES CHINA study was specifically designed to investigate the safety and efficacy of Resolute zotarolimus‐eluting stents (ZES; Medtronic, Santa Rosa, CA, USA) in the treatment of diabetic coronary lesions in the Chinese population.MethodsIn all, 945 patients with de novo native coronary lesions and type 2 diabetes mellitus were recruited at 32 cardiac centers across the Chinese mainland and were implanted with Resolute ZES. The primary endpoint was target vessel failure (TVF); secondary endpoints were clinical outcomes, namely all‐cause death, stroke, bleeding, target lesion revascularization (TLR), target vessel revascularization (TVR), non‐TVR, and stent thrombosis (ST). The follow‐up period for all endpoints was 12 months after the procedure.ResultsIn all, 933 patients (98.73%) had clinical follow‐up at 12 months. The rate of TVF was 11.60%, whereas the rate of occurrence of secondary endpoints was 5.47%, with four patients (0.43%) having subacute or late ST. There were no significant differences in TVF rates comparing patients with different HbA1c levels or receiving different glucose control treatments (all P > 0.05). Patients with multivessel lesions had higher TVF rates (95% confidence intervals) than those with single‐vessel lesions (16.76% [12.10%–22.97%) vs 9.72% [7.79%–12.11%], respectively; P = 0.006). There were no significant differences in TVF rates in patients with or without small vessels, bifurcated lesions, or chronic total occlusions (all P > 0.05). [Correction added on 17 January 2019, after first online publication: in the second sentence of Results section, “TLF” was changed to “TVF”.].ConclusionsResolute ZES may perform well in the Chinese diabetic population, especially in those with poor glucose control, complex lesions, and certain unfavorable clinical features. Further studies are needed to determine why ZES perform well in this population.