bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Decision-Making for Thrombolysis of Acute Minor Stroke Using Adaptive Conjoint Analysis
Authors: Liberman Ava L. , Pinto Daniel , Rostanski Sara K. , Labovitz Daniel L. , Naidech Andrew M. , Prabhakaran Shyam 
Published: September 2018

Introduction: There is practice variability in the treatment of patients with minor ischemic stroke with thrombolysis. We sought to determine which clinical factors physicians prioritize in thrombolysis decision-making for minor stroke using adaptive conjoint analysis. Methods: We conducted our conjoint analysis using the Potentially All Pairwise RanKings of all possible Alternatives methodology via the 1000Minds platform to design an online preference survey and circulated it to US physicians involved in stroke care. We evaluated 6 clinical attributes: language/speech deficits, motor deficits, other neurological deficits, history suggestive of increased risk of complication from thrombolysis, age, and premorbid disability. Survey participants were asked to choose between pairs of treatment scenarios with various clinical attributes; scenarios automatically adapted based on participants’ prior responses. Preference weights representing the relative importance of each attribute were compared using unadjusted paired t tests. Statistical significance was set at α = .05. Results: Fifty-four participants completed the survey; 61% were vascular neurologists and 93% worked in academic centers. All neurological deficits were ranked higher than age, premorbid status, or potential contraindications to thrombolysis. Differences between each successive mean preference weight were significant: motor (31.7%, standard deviation [SD]: 9.5), language/speech (24.1%, SD: 9.6), other neurological deficits (16.6%, SD: 6.4), premorbid status (12.9%, SD: 6.6), age (10.1%, SD: 6.3), and potential thrombolysis contraindication (4.7%, SD: 4.4). Conclusion: In a conjoint analysis, surveyed US physicians in academic practice assigned greater weight to motor and speech/language deficits than other neurological deficits, patient age, relative contraindications to thrombolysis, and premorbid disability when deciding to thrombolyse patients with minor stroke.
Patient Perceptions of Surgeon Reimbursement for Rotator Cuff Repair
Authors: Southam Brendan R. , Crawford Zachary , Grawe Brian M. 
Published: September 2018

Background: Previous studies in the arthroplasty, spine, and shoulder and elbow literature have shown that patients perceive Medicare reimbursement to surgeons to be much higher than current reimbursement schedules. Purpose: To evaluate patient perceptions of surgeon reimbursement for various rotator cuff repair (RCR) procedures. Study Design: Cross-sectional study. Methods: We surveyed 153 patients who presented to a single surgeon’s orthopaedic sports medicine clinic between October 2016 and March 2017. Patients with a new complaint of hip or knee pain, those with a new complaint of shoulder pain, or those who had undergone shoulder surgery 1 year or more prior to their current visit were included. Patients were asked how much they thought surgeons should be reimbursed for RCR procedures, including arthroscopic repair of a simple tear and a massive tear as well as open repair of an acute tear and a chronic tear. They were also asked to estimate how much they thought surgeons were reimbursed by Medicare for these procedures. They were then given actual Medicare reimbursement rates for these procedures and asked whether they believed surgeons should be reimbursed that amount. Results: For arthroscopic repair of a rotator cuff tear, patients believed that surgeons should receive a mean (±SEM) reimbursement of US$5645 ± $442. This was significantly more than their estimate of what surgeons were actually reimbursed by Medicare ($3644 ± $408; P = .001). Patients also believed that surgeons should be reimbursed more than their estimate of what surgeons were actually reimbursed for arthroscopic repair of a massive tear ($8066 ± $708 vs $4694 ± $476; P = .0001), open repair of an acute tear ($8428 ± $768 vs $4549 ± $396; P = .00001), and open repair of a chronic tear ($8902 ± $844 vs $4639 ± $438; P = .00001). Both types of patient perceptions were higher than the actual state Medicare reimbursement data for all procedures surveyed ( P < .001). Conclusion: Consistent with previous literature, patients perceive Medicare reimbursement for RCR to be higher than what surgeons are actually reimbursed. As the United States health care system enters a bundled care environment, price transparency is increasingly important. This study indicates a need for patient education on how their health care costs are allocated.
Quantitative Raman calibration of sulfate-bearing polymineralic mixtures: a S quantification in sedimentary rocks on Mars
Authors: Larre Chloé , Morizet Yann , Guillot-Deudon Catherine , Baron Fabien , Mangold Nicolas 
Published: September 2018

AbstractThe NASA 2020 Mars mission is a Curiosity-type rover whose objective is to improve the knowledge of the geological and climatic evolution of Mars and to collect rock samples for return to Earth. The new rover has a payload of seven instruments including the SuperCam instrument which consists of four tools including a Raman spectrometer. This Raman device will be non-destructive and will analyse the surface remotely in order to determine the mineralogy of rocks and, by extent, to detect and quantify major elements such as sulfur. Sulfur has been detected as sulfate (Ca,Mg,Fe-sulfates) in sedimentary rocks. This element is difficult to quantify using the laser ablation tool of the ChemCam instrument on-board the Curiosity rover.We propose a Raman calibration to constrain the sulfur abundance in polymineralic mixtures. We acquired Raman signatures on binary and ternary mechanical mixtures containing Ca and Mg sulfates, mixed with natural silicate minerals supposed to be relevant to basaltic-sedimentary rocks at the surface of Mars: olivine, clinopyroxene, orthopyroxene and plagioclase. Using the Voigt function to process the Raman spectra from samples extracted from our mixtures allows us to calculate the initial proportions of our preparations of Ca and Mg sulfates. From these simulations, calibration equations have been provided allowing us to determine sulfate proportions (CaSO4and MgSO4) in a mixture with basaltic minerals. With the presented calibration, S can be quantified at a lower limit of 0.7 wt.% in Martian soil.
Gem amphiboles from Mogok, Myanmar: crystal-structure refinement, infrared spectroscopy and short-range order–disorder in gem pargasite and fluoro-pargasite
Authors: Day Maxwell C. , Hawthorne Frank C. , Susta Umberto , Della Ventura Giancarlo , Harlow George E. 
Published: September 2018

AbstractThe crystal structures of six gem-quality pargasites and fluoro-pargasites from Mogok, Myanmar, space group C2/m, Z = 2, have been refined to R1 indices of 2.20–2.90% using MoKα X-radiation. The unit formulae were calculated from the results of electron-microprobe analysis, and were used with the refined site-scattering values and the observed mean bond lengths to assign site populations. TAl occurs at both the T(1) and T(2) sites but is strongly ordered at T(1). [6]Al is partly disordered over the M(2) and M(3) sites but does not occur at the M(1) site. ANa is split between the A(2) and A(m) sites and K occurs at the A(m) site. The infrared spectra in the principal OH-stretching region were measured and the fine structure was fit to component bands. The component bands were assigned to short-range ion arrangements over the configuration symbol M(1)M(1)M(3)–O(3)–A–O(3):T(1)T(1) using the refined site-populations and the expected frequencies from previously assigned spectra in more simple amphibole compositions, and correspond to the local arrangements: (1) MgMgMg–OH–Na–OH:SiAl; (2) MgMgMg–OH–Na–F:SiAl; (3) MgMgAl–OH–Na–OH:SiAl and (4) MgMgAl–OH–Na–F:SiAl.
A phase 1 trial evaluating thioridazine in combination with cytarabine in patients with acute myeloid leukemia
Authors: Aslostovar Lili , Boyd Allison L. , Almakadi Mohammed , Collins Tony J. , Leong Darryl P. , Tirona Rommel G. , Kim Richard B. , Julian Jim A. , Xenocostas Anargyros , Leber Brian , Levine Mark N. , Foley Ronan , Bhatia Mickie 
Published: September 2018

Key Points
Intermediate-dose cytarabine can be safely combined with TDZ at 50 mg every 6 hours in older patients with relapsed or refractory AML. A 5-day monotherapy with TDZ led to reduced blast counts in 5 out of 11 patients and was associated with patient-specific DRD2 level.
Elevated ecto-5′-nucleotidase: a missing pathogenic factor and new therapeutic target for sickle cell disease
Authors: Liu Hong , Adebiyi Morayo , Liu Rong Rong , Song Anren , Manalo Jeanne , Wen Yuan Edward , Wen Alexander Q. , Weng Tingting , Ko Junsuk , Idowu Modupe , Kellems Rodney E. , Eltzschig Holger K. , Blackburn Michael R. , Juneja Harinder S. , Xia Yang 
Published: September 2018

Key Points
CD73-mediated adenosine production contributes to SCD pathogenesis by promoting erythrocyte 2,3-BPG production and sickling. Specific inhibition of CD73 significantly attenuates disease severity of SCD mice and provides a novel therapeutic strategy to treat SCD.
CXCR5 and ICOS expression identifies a CD8 T-cell subset with TFH features in Hodgkin lymphomas
Authors: Le Kieu-Suong , Amé-Thomas Patricia , Tarte Karin , Gondois-Rey Françoise , Granjeaud Samuel , Orlanducci Florence , Foucher Etienne D. , Broussais Florence , Bouabdallah Reda , Fest Thierry , Leroux Dominique , Yadavilli Sapna , Mayes Patrick A. , Xerri Luc , Olive Daniel 
Published: September 2018

Key Points
A subset of CD8 T cells in some Hodgkin lymphomas shares phenotypic and functional features with CD4 TFH cells.
Outcomes of patients who developed subsequent solid cancer after hematopoietic cell transplantation
Authors: Inamoto Yoshihiro , Matsuda Tomohiro , Tabuchi Ken , Kurosawa Saiko , Nakasone Hideki , Nishimori Hisakazu , Yamasaki Satoshi , Doki Noriko , Iwato Koji , Mori Takehiko , Takahashi Satoshi , Yabe Hiromasa , Kohno Akio , Nakamae Hirohisa , Sakura Toru , Hashimoto Hisako , Sugita Junichi , Ago Hiroatsu , Fukuda Takahiro , Ichinohe Tatsuo , Atsuta Yoshiko , Yamashita Takuya 
Published: September 2018

Key Points
Subsequent solid cancers after HCT occurred at younger ages than primary cancers and accounted for most common causes of deaths. Subsequent solid cancers after HCT showed similar or worse survival compared with primary cancers in the general population.
Hematopoietic cell transplant for acute myeloid leukemia and myelodysplastic syndrome: conditioning regimen intensity
Authors: Eapen Mary , Brazauskas Ruta , Hemmer Michael , Perez Waleska S. , Steinert Patricia , Horowitz Mary M. , Deeg H. Joachim 
Published: September 2018

Key PointsBu4/Cy, Flu/Bu4, and Flu/Mel are optimal regimens for patients with AML in clinical remission or those with MDS. Flu/Mel, considered a less-intense regimen, is ideal for less fit patients.
Computational modeling and confirmation of leukemia-associated minor histocompatibility antigens
Authors: Lansford Jefferson L. , Dharmasiri Udara , Chai Shengjie , Hunsucker Sally A. , Bortone Dante S. , Keating James E. , Schlup Ian M. , Glish Gary L. , Collins Edward J. , Alatrash Gheath , Molldrem Jeffrey J. , Armistead Paul M. , Vincent Benjamin G. 
Published: September 2018

Key Points
Tissue-specific minor histocompatibility antigens can be predicted through computational analysis of donor and recipient genotyping data. Targeted mass spectrometry and tetramer analysis confirmed a computationally predicted, public leukemia antigen derived from GRK4.
Long-Term Risk of Venous Thromboembolism in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study
Authors: Madenci Arin L. , Weil Brent R. , Liu Qi , Murphy Andrew J. , Gibson Todd M. , Yasui Yutaka , Leisenring Wendy M. , Howell Rebecca M. , Tinkle Christopher L. , Nekhlyudov Larissa , Diller Lisa R. , Armstrong Gregory T. , Oeffinger Kevin C. , Weldon Christopher B. 
Published: September 2018

Purpose To estimate the incidence of late-occurring venous thromboembolism (VTE) among survivors of childhood cancer and to identify risk factors for VTE to facilitate diagnosis and prevention. Methods The Childhood Cancer Survivor Study is a multi-institutional cohort of 24,355 5-year childhood cancer survivors (diagnosed between 1970 and 1999; median age at last follow-up, 28.7 years [range, 5.6 to 58.9 years]; median follow-up since diagnosis, 21.3 years [range, 5.0 to 39.2 years]) and 5,051 sibling participants. The primary end point was self-reported late (≥ 5 years after cancer diagnosis) VTE. Rate ratios (RRs) were estimated with multivariable piecewise exponential models. Results Late VTE incidence among survivors and siblings was 1.1 and 0.5 events per 1,000 person-years, respectively (RR, 2.2; 95% CI, 1.7 to 2.8), with 2.5 excess events per 100 survivors over 35 years. Among survivors, risk factors for VTE were female sex (RR, 1.3; 95% CI, 1.1 to 1.6), cisplatin (reference none; 1 to 199 mg/m2: RR, 3.0 [95% CI, 1.4 to 6.5]; 200 to 399 mg/m2: RR, 1.9 [95% CI, 1.0 to 3.6]; ≥ 400 mg/m2: RR, 2.0 [95% CI, 1.2 to 3.3]), l-asparaginase (RR, 1.3; 95% CI, 1.0 to 1.7), obesity or underweight (reference body mass index [BMI] 18.5 to 24.9 kg/m2; BMI ≥ 30.0 kg/m2: RR, 1.6 [95% CI, 1.2 to 2.0]; BMI < 18.5 kg/m2: RR, 2.4 [95% CI, 1.7 to 3.4]), and late cancer recurrence or subsequent malignant neoplasm (RR, 4.6; 95% CI, 3.6 to 5.8). Among lower-extremity osteosarcoma survivors, limb salvage (reference amputation; RR, 3.1; 95% CI, 1.2 to 7.5) and cisplatin 200 to 399 or ≥ 400 mg/m2 (reference none; RR, 4.0 [95% CI, 1.1 to 14.6] and 2.9 [95% CI, 1.1 to 8.0], respectively) were independently associated with late VTE. VTE was associated with increased risk for nonexternal cause late mortality (RR, 1.9; 95% CI, 1.6 to 2.3). Conclusion Childhood cancer survivors are at increased risk for VTE across their lifespan and a diagnosis of VTE increases mortality risk. Interventions that target potentially modifiable comorbidities, such as obesity, warrant consideration, with prophylaxis for high-risk survivors, including those treated with cisplatin and limb-sparing approaches.
Clonal analysis reveals laminar fate multipotency and daughter cell apoptosis of mouse cortical intermediate progenitors
Authors: Mihalas Anca B. , Hevner Robert F. 
Published: September 2018

ABSTRACT
In developing cerebral cortex, most pyramidal-projection neurons are produced by intermediate progenitors (IPs), derived in turn from radial glial progenitors. Although IPs produce neurons for all cortical layers, it is unknown whether individual IPs produce multiple or single laminar fates, and the potential of IPs for extended proliferation remains uncertain. Previously, we found that, at the population level, early IPs (present during lower-layer neurogenesis) produce lower- and upper-layer neurons, whereas late IPs produce upper-layer neurons only. Here, we employed mosaic analysis with double markers (MADM) in mice to sparsely label early IP clones. Most early IPs produced 1-2 neurons for deep layers only. Less frequently, early IPs produced larger clones (up to 12 neurons) spanning lower and upper layers, or upper layers only. The majority of IP-derived clones (∼66%) were associated with asymmetric cell death after the first division. These data demonstrate that laminar fate is not predetermined, at least in some IPs. Rather, the heterogeneous sizes and laminar fates of early IP clones are correlated with cell division/death/differentiation choices and neuron birthdays, respectively.
Effect of various organic acid supplementation diets on Clarias gariepinus BURCHELL, 1822: Evaluation of growth, survival and feed utilization
Authors: Asriqah Lia , Nugroho Rudy Agung , Aryani Retno 
Published: September 2018

Background: The purpose of the current study was to determine the growth status, survival and feed utilization of catfish (Clarias gariepinus BURCHELL, 1822) fed various organic acid supplementations. Methods: In total, 1600 fish were randomly distributed into 20 tanks and fed different types of diet: A, control diet without organic acid supplementation; B, control diet supplemented with 0.05% formic, acetic, and propionic acid; C, control diet supplemented with 0.1% formic, acetic, and propionic acid; D, control diet supplemented with 0.05% butyric acid; E, control diet supplemented with 0.01% butyric acid. The control diet was a commercial diet, containing 35% crude protein, 8.58% crude fat, and 2.75% fibre. All fish were fed using a satiation method, three times per day for 56 days. At the end of the trial, growth, survival and feed utilization were determined. Water quality parameters during the trial were also measured once a week. Results: Fish fed diet type D had the significantly lowest (P<0.05) final weight (FW), weight gain (WG), and specific growth rate (SGR) of all diets. Similar FW, WG, and SGR were found for fish fed diets A-C and E. Meanwhile, the feed conversion ratio, feed efficiency, and survival rate of fish were not affected by any types of diet. The water quality parameters were not significantly different between tanks and weeks: dissolved oxygen 6.79-6.81 mg L-1, pH 7.11-7.19, water temperature 28.97-29.32°C, nitrite (NO2) content 0.48- 0.50 mg L-1, and ammonia (NH3) content 0.064-0.066 mg L-1. Conclusion: The supplementation of 0.05% butyric acid in the diet of C. gariepinus for 56 days reduced the growth performance of the fish. However, supplementation of an organic acid in the diet of C. gariepinus had no impact on feed utilization, survival, and water quality parameters.
Comparing Ethnicity-Specific Reference Intervals for Clinical Laboratory Tests from EHR Data
Authors: Rappoport Nadav , Paik Hyojung , Oskotsky Boris , Tor Ruth , Ziv Elad , Zaitlen Noah , Butte Atul J 
Published: September 2018

Abstract

Background
The results of clinical laboratory tests are an essential component of medical decision-making. To guide interpretation, test results are returned with reference intervals defined by the range in which the central 95% of values occur in healthy individuals. Clinical laboratories often set their own reference intervals to accommodate variation in local population and instrumentation. For some tests, reference intervals change as a function of sex, age, and self-identified race and ethnicity.

Methods
In this work, we develop a novel approach, which leverages electronic health record data, to identify healthy individuals and tests for differences in laboratory test values between populations.

Results
We found that the distributions of &gt;50% of laboratory tests with currently fixed reference intervals differ among self-identified racial and ethnic groups (SIREs) in healthy individuals.

Conclusions
Our results confirm the known SIRE-specific differences in creatinine and suggest that more research needs to be done to determine the clinical implications of using one-size-fits-all reference intervals for other tests with SIRE-specific distributions.
Reagents that Contain Se-H or Te-H Bonds
Authors: Ho Peter C. , Wang Jin , Vargas-Baca Ignacio 
Published: September 2018

Abstract
Species that contain bonds between hydrogen and selenium or tellurium have a characteristic high reactivity, which can be harnessed in the synthesis of valuable organic compounds. This overview includes the synthesis of dihydrides, alkali metal hydrochalcogenides, chalcogenols, chalcogenocarboxylic and chalcogenocarbamic acids, and their application in reactions of reduction, addition to unsaturated compounds, and nucleophilic substitution.
Accelerated Healing in Asphalt Concrete via Laboratory Microwave Heating
Authors: Wang Haopeng , Yang Jun , Lu Guoyang , Liu Xueyan 
Published: September 2018

Abstract
Self-healing of asphalt concrete (AC) is highly dependent on temperature, and its healing capacity increases with elevated temperatures. The main objective of this study is to investigate the effect of microwave heating on promotion of self-healing in AC. With this purpose, two types of AC specimens (neat AC without additives and conductive AC containing steel fiber and graphite) were prepared to for use in thermal conductivity, microwave heating speed tests, four-point bending fatigue, and healing tests. In addition, oscillatory frequency sweep tests were carried out to obtain the flow behavior of asphalt binder. Results indicated that AC containing electrically conductive additives had a higher thermal conductivity and microwave heating speed than neat AC. It was also found that the fatigue resistance and healing capacity of conductive AC after microwave heating were higher than that of neat AC. Moreover, there exists a critical temperature (corresponding to near-Newtonian behavior temperature of asphalt binder) above which healing of AC starts and an optimum heating time (temperature) to maximize the healing effect. Finally, it was found that an intermittent heating mode with a cooling process is more effective than the consecutive heating mode to enhance the healing capacity of AC. Based on these findings, it is concluded that self-healing efficiency of AC can be enhanced via microwave heating.
La familia Bromeliaceae en México
Authors: Espejo-Serna Adolfo , López-Ferrari Ana Rosa 
Published: September 2018

Antecedentes: Las Bromeliaceae mexicanas han despertado el interés de los botánicos desde 1789; su estudio sistemático inició a partir de la década de los setenta del siglo pasado, contando actualmente con avances significativos en su conocimiento taxonómico-florístico.Pregunta: ¿Cuántas y cuáles especies de Bromeliaceae se presentan en México? ¿Cómo están distribuidas y cuántas son endémicas?Sitio de estudio: México, 1887-2017.Métodos: Con base en el estudio de las Bromeliaceae de México, incluyendo recolecciones botánicas, revisión de literatura y consulta, cotejo y determinación de ejemplares en 50 herbarios nacionales y extranjeros, se obtuvieron datos sobre riqueza, endemismo y distribución de sus representantes en el país.Resultados: En México están representadas cuatro de las ocho subfamilias de Bromeliaceae, 19 géneros, 422 especies y 8 taxones infraespecíficos. Los géneros más ricos en especies son Tillandsia (230/54.5 %), Hechtia (71/16.8 %) y Pitcairnia (50/11.8 %). Trescientas dieciocho especies, así como los géneros Ursulaea y Viridantha, son endémicos de México; 172 especies son microendémicas. La entidad con más taxones es Oaxaca, seguida por Chiapas, Veracruz y Guerrero y las que cuentan con menor representación son Tlaxcala y Baja California Sur. Baja California, Baja California Sur, Campeche, Ciudad de México, San Luis Potosí, Sonora, Tabasco y Tlaxcala no tienen taxones endémicos estrictos.Conclusión: Aunque el avance del conocimiento de las Bromeliaceae mexicanas ha sido constante, todavía se requiere de trabajo de exploración y recolección en algunas regiones del país, antes de concluir la flora Bromeliológica Mexicana. También es necesario abordar aspectos de conservación y aprovechamiento sustentable.