bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience-dependent development of dendritic arbors in mouse visual cortex
Authors: Richards Sarah E.V. , Moore Anna R. , Nam Alice Y. , Saxena Shikhar , Paradis Suzanne , Van Hooser Stephen D. 
Published: September 2019

AbstractDespite the importance of dendritic arbors for proper neuronal function, our knowledge of how sensory experience influences these structures during postnatal cortical development is incomplete. We present a large-scale dataset of 849 three-dimensional reconstructions of pyramidal neuron basal arbors collected across early postnatal development in the mouse visual cortex. We found that the basal arbor underwent a 45% increase in total length between postnatal day 7 (P7) and P30. Surprisingly, comparisons of dark-reared and typically-reared mice revealed that only 15% of arbor length could be attributed to visual experience. Furthermore, we characterized the role of the activity-regulated small GTPase Rem2, showing that Rem2 is an experience-dependent negative regulator of dendritic segment number during the visual critical period. These data establish a detailed, quantitative analysis of the basal arbor that has high utility for understanding circuit development and providing a framework for computationalists wishing to generate anatomically accurate neuronal models.
Experimental Evidence for Constraints in Amplitude-Timescale Co-variation of a Biomolecular Pulse Generating Circuit Design
Authors: Patel Abhilash , Sen Shaunak 
Published: September 2019

AbstractUnderstanding constraints on the functional properties of biomolecular circuit dynamics, such as the variation of amplitude and timescale of pulse, is an important part of biomolecular circuit design. While the amplitude-timescale co-variations of the pulse in an incoherent feedforward loop have been investigated computationally using mathematical models, experimental support for such constraints is relatively unclear. Here, we address this using experimental measurements of an existing pulse generating incoherent feedforward loop circuit realization in the context of a standard mathematical model. We characterize the trends of co-variation in the pulse amplitude and rise time computationally by randomly exploring the parameter space. We experimentally measured the co-variation by varying inducers and found that larger amplitude pulses have slower rise time. We discuss the gap between the experimental measurements and predictions of the standard model, highlighting model additions and other biological factors that might bridge the gap.
The ESCRT-III Isoforms CHMP2A And CHMP2B Display Different Effects On Membranes Upon Polymerization
Authors: Alqabandi Maryam , de Franceschi Nicola , Miguet Nolwenn , Maity Sourav , Bally Marta , Roos Wouter H. , Weissenhorn Winfried , Bassereau Patricia , Mangenot Stéphanie 
Published: September 2019

ABSTRACTESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, CHMP2 exists as two potential isoforms, CHMP2A and CHMP2B, but their physical characteristics have not been compared yet. Here, we use a combination of technics on biomimetic systems and purified proteins to study their affinity and effects on membranes. We establish that CHMP2B binding is enhanced in the presence of PI(4,5)P2 lipids. In contrast, CHMP2A does not display lipid specificity and requires CHMP3 for binding significantly to membranes. On the micrometer scale and at moderate bulk concentrations, CHMP2B forms a reticular structure on membranes whereas CHMP2A (+CHMP3) binds homogeneously. Eventually, CHMP2A and CHMP2B unexpectedly induce different mechanical effects to membranes: CHMP2B strongly rigidifies them while CHMP2A (+CHMP3) has no significant effect. Altogether, we conclude that CHMP2B and CHMP2A cannot be considered as isoforms and might thus contribute differently to membrane remodeling processes.
Structural studies of MMP-3 interaction with triple-helical collagen introduce the enzyme’s new roles in tissue remodelling
Authors: Manka Szymon W. , Bihan Dominique , Farndale Richard W. 
Published: September 2019

AbstractMatrix metalloproteinase-3 (MMP-3 or stromelysin 1) participates in normal extracellular matrix (ECM) turnover during embryonic development, organ morphogenesis and wound healing, and in tissue-destructive diseases, such as aneurysm, cancer, arthritis and heart failure. Despite its ability to hydrolyse numerous proteins in the ECM, MMP-3 fails to cleave the triple helix of interstitial fibrillar collagens. Nonetheless, it can still bind to these collagens although the mechanism, location and role of binding are not known. We used the Collagen Toolkits, libraries of triple-helical peptides that embrace the entire helical domains of collagens II and III, to map MMP-3 interaction sites. The enzyme recognises five sites on collagen II and three sites on collagen III. They share a glycine-phenylalanine-hydroxyproline/alanine (GFO/A) motif that is recognised by the enzyme in a context-dependent manner. Neither MMP-3 zymogen (proMMP-3) nor the individual catalytic (Cat) and hemopexin (Hpx) domains of MMP-3 interact with the peptides, revealing cooperative binding of both domains to the triple helix. The Toolkit binding data combined with molecular modelling enabled us to deduce the putative collagen-binding mode of MMP-3, where all three collagen chains make contacts with the enzyme in the valley running across both Cat and Hpx domains. The observed binding pattern casts light on how MMP-3 could regulate collagen turnover and compete with various collagen-binding proteins regulating cell adhesion and proliferation.
A framework for electrified propulsion architecture and operation analysis
Authors: Cinar Gokcin , Garcia Elena , Mavris Dimitri N. 
Published: September 2019

Purpose
The purpose of this paper was to create a generic and flexible framework for the exploration, evaluation and side-by-side comparison of novel propulsion architectures. The intent for these evaluations was to account for varying operation strategies and to support architectural design space decisions, at the conceptual design stages, rather than single-point design solutions.

Design/methodology/approach
To this end, main propulsion subsystems were categorized into energy, power and thrust sources. Two types of matrices, namely, the property and interdependency matrices, were created to describe the relationships and power flows among these sources. These matrices were used to define various electrified propulsion architectures, including, but not limited to, turboelectric, series-parallel and distributed electric propulsion configurations.

Findings
As a case study, the matrices were used to generate and operate the distributed electric propulsion architecture of NASA’s X-57 Mod IV aircraft concept. The mission performance results were acceptably close to the data obtained from the literature. Finally, the matrices were used to simulate the changes in the operation strategy under two motor failure scenarios to demonstrate the ease of use, rapidness and automation.

Originality/value
It was seen that this new framework enables rapid and analysis-based comparisons among unconventional propulsion architectures where solutions are driven by requirements.
Financial statement analysis
Authors: Mbona Reginald Masimba , Yusheng Kong 
Published: September 2019

Purpose
The Chinese Telecoms Industry has been rapidly growing over the years since 2001. An analysis of financial performance of the three giants in this industry is very important. However, it is difficult to know how many ratios can be used best with little information loss. The paper aims to discuss this issue.

Design/methodology/approach
A total of 18 financial ratios were calculated based on the financial statements for three companies, namely, China Mobile, China Unicom and China Telecom for a period of 17 years. A principal component analysis was run to come up with variables with significance value above 0.5 from each component.

Findings
At the end, the authors conclude how financial performance can be analysed using 12 ratios instead of the costly analysis of too many ratios that may be complex to interpret. The results also showed that ratios are all related as they come from the same statements, hence, the authors can use a few to represent the rest with limited loss of information.

Originality/value
This study will help different stakeholders who are interested in the financial performance of each company by giving them a shorter way to analyse performance. It will also assist those who do financial reporting on picking the ratios which matter in reflecting the performance of their companies. The use of PCA gives unbiased ratios that are most significant in assessing performance.
Integral and differential nonlocal micromorphic theory
Authors: Norouzzadeh Amir , Faraji Oskouie Mohammad , Ansari Reza , Rouhi Hessam 
Published: September 2019

Purpose
This paper aims to combine Eringen’s micromorphic and nonlocal theories and thus develop a comprehensive size-dependent beam model capable of capturing the effects of micro-rotational/stretch/shear degrees of freedom of material particles and nonlocality simultaneously.

Design/methodology/approach
To consider nonlocal influences, both integral (original) and differential versions of Eringen’s nonlocal theory are used. Accordingly, integral nonlocal-micromorphic and differential nonlocal-micromorphic beam models are formulated using matrix-vector relations, which are suitable for implementing in numerical approaches. A finite element (FE) formulation is also provided to solve the obtained equilibrium equations in the variational form. Timoshenko micro-/nano-beams with different boundary conditions are selected as the problem under study whose static bending is addressed.

Findings
It was shown that the paradox related to the clamped-free beam is resolved by the present integral nonlocal-micromorphic model. It was also indicated that the nonlocal effect captured by the integral model is more pronounced than that by its differential counterpart. Moreover, it was revealed that by the present approach, the softening and hardening effects, respectively, originated from the nonlocal and micromorphic theories can be considered simultaneously.

Originality/value
Developing a hybrid size-dependent Timoshenko beam model including micromorphic and nonlocal effects. Considering the nonlocal effect based on both Eringen’s integral and differential models proposing an FE approach to solve the bending problem, and resolving the paradox related to nanocantilever.
A reconfigurable model for implementation in the closing phase of a wind turbines project construction
Authors: Zohrehvandi Shakib , Vanhoucke Mario , Soltani Roya , Javadi Mehrdad 
Published: September 2019

Purpose
The purpose of this paper is to introduce a reconfigurable model that is a combination of a schedule model and a queuing system M/M/m/K to reduce the duration of the wind turbine construction project closure phase and reduce the project documentation waiting time in the queue.

Design/methodology/approach
This research was implemented in a wind farm project. The schedule model deals with reducing the duration of the turbines closure phase by an activity overlapping technique, and the queuing system deals with reducing the turbine documentation waiting time in the queue, as well as reducing the probability of server idleness during the closure phase.

Findings
After the implementation of the model, the obtained results were compared to those of similar previously conducted projects in terms of duration, and the model was found effective.

Research limitations/implications
Project closure is an important and mandatory process in all projects. More often than not, this process is faced with problems including prolonged project duration, disputes, lawsuits, and also in projects like the implementation of wind farms, a queue of documents at closing stage may also cause difficulties in project closure phase.

Originality/value
The contributions of this research are twofold: first, a combination of project management and queuing system is presented, and second, a reconfigurable model is introduced to enhance the performance and productivity of the closure phase of the project through reducing the implementation time and reducing the turbine documentation waiting time in the queue, as well as reducing the probability of server idleness during the closure phase of the wind farm project.
Conformance or evasion
Authors: Najeeb Ali , Barrett Mary 
Published: September 2019

PurposeThe purpose of this paper is to investigate how resort managers respond to employment legislation (Law No. 02/2008).Design/methodology/approachThe qualitative case study data from seven self-contained tourist resorts in the Maldives were used to investigate the managerial responses to employment legislation.FindingsResort managers’ responses ranged from passive compliance to active resistance, with decoupling through opportunism as the dominant strategy used to circumvent the legislation. Some human resource management (HRM) practices emerged from resort managers’ interactions with external stakeholders and employees. Strategic responses and HRM practices were driven by a search for legitimacy or efficiency and sometimes both. The findings show that there are differences between strategic responses and HRM practices by organisational subfield, local resorts and international hotel chains. The resorts’ market orientation also influenced resort managers’ responses and HRM practices.Research limitations/implicationsThe findings of this paper have limitations because it was limited to a single industry/sector and to a particular piece of legislation. However, it demonstrates the complexity of the relationship between institutional context and HRM.Originality/valueThis paper shows that responding to employment legislation entails a high level of interplay between the institutional environment and HR actors, and between stakeholders (e.g. employees) and HR actors. It demonstrates the difficulty of reconciling institutional requirements with the preferences of different stakeholders and organisational interests. HR actors actively make sense of institutional requirements and modify HRM practices to accommodate stakeholders’ varying perspectives and preferences. This suggests that in countries such as the Maldives, uneven institutional coverage (e.g. incomplete employment legislation) allows room for organisations to innovate – for better or worse.
Identification of temperature-dependent boundary conditions using MOR
Authors: Frank Tobias , Wieting Steffen , Wielitzka Mark , Bosselmann Steffen , Ortmaier Tobias 
Published: September 2019

Purpose
A mathematical description of temperature-dependent boundary conditions is crucial in manifold model-based control or prototyping applications, where accurate thermal simulation results are required. Estimation of boundary condition coefficients for complex geometries in complicated or unknown environments is a challenging task and often does not fulfill given accuracy limits without multiple manual adaptions and experiments. This paper aims to describe an efficient method to identify thermal boundary conditions from measurement data using model order reduction.

Design/methodology/approach
An optimization problem is formulated to minimize temperature deviation over time between simulation data and available temperature sensors. Convection and radiation effects are expressed as a combined heat flux per surface, resulting in multiple temperature-dependent film coefficient functions. These functions are approximated by a polynomial function or splines, to generate identifiable parameters. A formulated reduced order system description preserves these parameters to perform an identification. Experiments are conducted with a test-bench to verify identification results with radiation, natural and forced convection.

Findings
The generated model can approximate a nonlinear transient finite element analysis (FEA) simulation with a maximum deviation of 0.3 K. For the simulation of a 500 min cyclic cooling and heating process, FEA takes a computation time of up to 13 h whereas the reduced model takes only 7-11 s, using time steps of 2 s. These low computation times allow for an identification, which is verified with an error below 3 K. When film coefficient estimation from literature is difficult due to complex geometries or turbulent air flows, identification is a promising approach to still achieve accurate results.

Originality/value
A well parametrized model can be further used for model-based control approaches or in observer structures. To the knowledge of the authors, no other methodology enables model-based identification of thermal parameters by physically preserving them through model order reduction and therefore derive it from a FEA description. This method can be applied to much more complex geometries and has been used in an industrial environment to increase product quality, due to accurate monitoring of cooling processes.
The effects of elastane and finishing properties on wicking, drying and water vapour permeability properties of denim fabrics
Authors: Eryuruk Selin Hanife 
Published: September 2019

PurposeThe liquid water and water vapour transfer properties of fabrics play an important and decisive role in determining thermal comfort properties of clothing systems. The purpose of this paper is to analyse the effects of fabric composition (98 percent cotton–2 percent elastane and 100 percent cotton) and finishing treatments (rigid, resin, bleaching and softening) on the wicking, drying and water vapour permeability (WVP) properties of denim fabrics.Design/methodology/approachThe research design for this study consists of experimental study. Two fabric compositions (98 percent cotton–2 percent elastane and 100 percent cotton) and four finishing treatments (rigid, resin, bleaching and softening) were evaluated to see the effects of elastane and finishing treatments on wicking, drying and WVP properties of woven denim fabrics. Results were analysed statistically.FindingsExperimental results showed that the transfer wicking, drying and WVP values of denim fabrics were significantly influenced by fabric weight, fibre composition and finishing treatments.Practical implicationsThe wicking ability of sweat from the skin to the outer environment of a skin contact fabric layer is the primary requirement.Originality/valueAs a result of the literature review, it was seen that there are some studies in the literature about comfort properties of denim fabrics, but there is no study concerning the water vapour transmission, wicking and drying properties of denim fabrics.
Monaco’s struggle to become a smart destination
Authors: Fabry Nathalie , Blanchet Cyril 
Published: September 2019

PurposeMonaco is a simultaneously a destination, a state and a city, which belongs to the long list of places that aims to become smart. The purpose of this paper is to present Monaco’s transformation strategy from October 2017 to May 2019. It will present Monaco’s smart urban ecosystem as a meeting point between the destination and the smart city.Design/methodology/approachThe authors develop the methodology as an exploratory observation of the state transformations. The methodology relies on an understanding of smart cities policy from an insider perspective, as one of the co-authors participates in the “Matrice Smart-City Monaco” program (Season 1: Tourism), on a media coverage analysis and in a semi-directive interview with a stakeholder of the digital transformation in Monaco.FindingsThe paper empirically and theoretically explores the following three hypotheses: H1 – being a smart city/destination is less a status than a process; H2 – a permeable state city challenges the boundaries between the city and the smart destination; and H3 – the conceptualization of the smart city requires a broader definition of who its engaged stakeholders are.Research limitations/implicationsThe case of Monaco helps us to understand the role of tourism in a smart city and to deepen the link between “smart city” and “smart destination” from a theoretical point of view. Monaco offers us the opportunity to reinforce our understanding of the relationship between the smart city and the smart destination.Originality/valueThe study concerns a micro-state that aims to become smart using a top–down strategy. However, for a city to become smart, stakeholders including citizens must be able to support the process.
“The right information”: perceptions of information bias among Black Wikipedians
Authors: Ju Boryung , Stewart Brenton 
Published: September 2019

PurposeThe purpose of this paper is to examine motivators that drive Black Wikipedia contribution. The authors explore motivations around content contribution, effects of gender on motivations and self-perceptions of Black Wikipedia labor.Design/methodology/approachA total of 318 Black American Wikipedia contributors completed an online survey. The authors employed both quantitative and qualitative methods in the study including descriptive statistics, multivariate (MANOVA) and univariate (ANOVA) analysis of variance to examine gender differences in Wikipedia content contribution. In addition, open-ended responses were evaluated, through content analysis, to make inferences on their perceptions of Wikipedia labor.FindingsThis paper identifies racial identity and perceptions of information quality as strong motivators in content contribution among Black Wikipedians. Motivators are gender variant; men are more motivated than women with the lone exception being racial identity. Additionally, the study identifies Wikipedia as a contested space among Black contributors and is a site of resistance.Originality/valueBlack Wikipedians information activity is a relatively new and understudied phenomenon. This paper presents new insight and a deeper understanding of Black Wikipedians’ motivations for information sharing behaviors in the most popular encyclopedia on the internet.
The vascular endothelium plays a role in insulin action
Authors: Kolka Cathryn M. 
Published: September 2019

AbstractThe endocrine system relies on the vasculature for delivery of hormones throughout the body, and the capillary microvasculature is the site where the hormones cross from the blood into the target tissue. Once considered an inert wall, various studies have now highlighted the functions of the capillary endothelium to regulate transport and therefore affect or maintain the interstitial environment. The role of the capillary may be clear in areas where there is a continuous endothelium, yet there also appears to be a role of endothelial cells in tissues with a sinusoidal structure. Here we focused on the most common endocrine disorder, diabetes, and several of the target organs associated with the disease, including skeletal muscle, liver and pancreas. However, it is important to note that the ability of hormones to cross the endothelium to reach their target tissue is a component of all endocrine functions. It is also a consideration in organs throughout the body and may have greater impact for larger hormones with target tissues containing a continuous endothelium. We noted that the blood levels do not always equal interstitial levels, which is what the cells are exposed to, and discussed how this may change in diseases such as obesity and insulin resistance. The capillary endothelium is, therefore, an essential and understudied aspect of endocrinology and metabolism that can be altered in disease, which may be an appropriate target for treatment.