bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dramatically diverseS. pombe wtfmeiotic drivers all display high gamete-killing efficiency
Authors: Bravo Núñez María Angélica , Sabbarini Ibrahim M. , Eickbush Michael T. , Liang Yue , Lange Jeffrey J. , Kent Aubrey M. , Zanders Sarah E. 
Published: August 2019

AbstractMeiotic drivers are selfish genetic loci that force their transmission into more than 50% of the viable gametes made by heterozygotes. Meiotic drivers are known to cause infertility in a diverse range of eukaryotes and are predicted to affect the evolution of genome structure and meiosis. Thewtfgene family ofSchizosaccharomyces pombeincludes both meiotic drivers and drive suppressors and thus offers a tractable model organism to study drive systems. Currently, only a handful ofwtfgenes have been functionally characterized and those genes only partially reflect the diversity of thewtfgene family. In this work, we functionally test 22 additionalwtfgenes. We identify eight new drivers that share between 30-90% amino acid identity with previously characterized drivers. Despite the vast divergence between these genes, they generally drive into >85% gametes when heterozygous. We also find three newwtfgenes that suppress drive, including two that also act as autonomous drivers. Additionally, we find thatwtfgenes do not underlie a weak (64%) transmission bias caused by a locus or loci on chromosome 1. Finally, we find that some Wtf proteins have expression or localization patterns that are distinct from the poison and antidote proteins encoded by drivers and suppressors, suggesting somewtfgenes may have non-meiotic drive functions. Overall, this work expands our understanding of thewtfgene family and the burden selfish driver genes impose onS. pombe.Article SummaryDuring gametogenesis, the two gene copies at a given locus, known as alleles, are each transmitted to 50% of the gametes (e.g. sperm). However, some alleles cheat so that they are found in more than the expected 50% of gametes, often at the expense of fertility. This selfish behavior is known as meiotic drive. Some members of thewtfgene family in the fission yeast,Schizosaccharomyces pombe, kill the gametes (spores) that do not inherit them, resulting in meiotic drive favoring thewtfallele. Otherwtfgenes act as suppressors of drive. However, thewtfgene family is diverse and only a small subset of the genes has been characterized. Here we analyze the functions of other members of this gene family and found eight new drivers as well as three new suppressors of drive. Surprisingly, we find that drive is relatively insensitive to changes inwtfgene sequence as highly divergedwtfgenes execute gamete killing with similar efficiency. Finally, we also find that the expression and localization of some Wtf proteins are distinct from those of known drivers and suppressors, suggesting that these proteins may have non-meiotic drive functions.
Identification of biomarkers associated with ovarian cancer based on transcriptome sequencing
Authors: chen jiazhou , peng xiandong , yu min 
Published: August 2019

AbstractObjectiveThis study aimed to explore more biomarkers associated with ovarian cancer.MethodsCell lines SKOV-3 (ovarian serous carcinoma cells) and MCV152 (benign ovarian epithelial tumor cell) were used in this study and performed transcriptome sequencing. The differentially expressed genes (DEGs) between ovarian cancer cells (SKOV-3) and controls (MCV152) were identified, followed by function enrichment analysis. The expression levels of genes involved in the key pathway were validated through PCR and western blot analyses.ResultsTotal 2,020 upregulated and 1,673 downregulated DEGs were obtained between SKOV3 and MCV152 cells. The upregulated and downregulated DEGs were significantly associated with cell adhesion. In addition, the upregulated DEGs were significantly involved in pathways of ECM-receptor interaction, and the downregulated DEGs were involved in PI3K-Akt signaling pathway. PCR and western blot analyses showed that genes (proteins) expression related to PI3K-Akt signaling pathway were in consistent with bioinformatics analysis.ConclusionCell adhesion and extracellular matrix (ECM)-receptor interaction may play an important role in the invasion of ovarian cancer. PI3K-Akt signaling pathway may be involved in the progression of ovarian cancer by up-regulating ANGPT2, FGF18, ITGB4 and ITGB8, and downregulating AKT3 and PIK3AP1.HighlightsCell adhesion and ECM-receptor interaction may play important roles in ovarian cancer invasion.PI3K-Akt signaling pathway may involve in ovarian cancer progression.ANGPT2, FGF18, ITGB4, ITGB8, AKT3 and PIK3AP1 may serve as biomarkers in ovarian cancer.
Research on software synchronization method of real-time ethernet distributed motion control system
Authors: Huang Zhengyu , Chen Lingyu , Zhang Lianchao , Fan Shixun , Fan Dapeng 
Published: August 2019

Purpose
This paper aims to analyze the key factors influencing the synchronization performance of distributed motion control system and to improve the synchronization performance for peripherals control of this system.

Design/methodology/approach
This paper deals with the software synchronization problems of distributed motion control system based on real-time Ethernet. First, combined with communication and control tasks, the key factors affecting synchronization performance of system are analyzed. Then, aiming at key factors and considering the synchronization of system bus, protocol conversion and task scheduling, a software synchronization method based on CANopen protocol and real-time Ethernet is proposed. Finally, the feasibility of this method is verified by establishing distributed motion control system and testing the synchronization performance of terminal control signals of slaves.

Findings
Based on this method, the results show that the synchronization accuracy for peripherals control of all slaves could be about 100 ns.

Practical implications
This research provides high-precision synchronization method, which could lay a foundation for the application of distributed motion control system in the field of assembly automation, such as multi-axis assembly robots control.

Originality/value
In distributed motion control system, many factors affect the synchronization performance. At present, there is no synchronization method that could comprehensively consider these factors. This paper not only analyzes the key factors influencing the synchronization performance of system but also proposes a synchronization method. Therefore, the method proposed in this paper has certain theoretical value and engineering significance.
A novel PGSA–PSO hybrid algorithm for structural optimization
Authors: Jiang Zhengrong , Lin Quanpan , Shi Kairong , Pan Wenzhi 
Published: August 2019

Purpose
The purpose of this paper is to propose a new hybrid algorithm, named improved plant growth simulation algorithm and particle swarm optimization hybrid algorithm (PGSA–PSO hybrid algorithm), for solving structural optimization problems.

Design/methodology/approach
To further enhance the optimization efficiency and precision of this algorithm, the optimization solution process of PGSA–PSO comprises two steps. First, an excellent initial growth point is selected by PSO. Then, the global optimal solution can be obtained quickly by PGSA and its improved strategy called growth space adjustment strategy. A typical mathematical example is provided to verify the capacity of the new hybrid algorithm to effectively improve the global search capability and search efficiency of PGSA. Moreover, PGSA–PSO is applied to the optimization design of a suspended dome structure.

Findings
Through typical mathematical example, the improved strategy can improve the optimization efficiency of PGSA considerably, and an initial growth point that falls near the global optimal solution can be obtained. Through the optimization of the pre-stress of a suspended dome structure, compared with other methods, the hybrid algorithm is effective and feasible in structural optimization.

Originality/value
Through the examples of suspended dome structure, it shows that the optimization efficiency and precision of PGSA–PSO are better than those of other algorithms and methods. PGSA–PSO is effective and feasible in structural optimization problems such as pre-stress optimization, size optimization, shape optimization and even topology optimization.
Non-invasive implementation of nonlinear isogeometric analysis in an industrial FE software
Authors: Tirvaudey Marie , Bouclier Robin , Passieux Jean-Charles , Chamoin Ludovic 
Published: August 2019

Purpose
The purpose of this paper is to further simplify the use of NURBS in industrial environnements. Although isogeometric analysis (IGA) has been the object of intensive studies over the past decade, its massive deployment in industrial analysis still appears quite marginal. This is partly due to its implementation, which is not straightforward with respect to the elementary structure of finite element (FE) codes. This often discourages industrial engineers from adopting isogeometric capabilities in their well-established simulation environment.

Design/methodology/approach
Based on the concept of Bézier and Lagrange extractions, a novel method is proposed to implement IGA from an existing industrial FE code with the aim of bringing human implementation effort to the minimal possible level (only using standard input-output of finite element analysis (FEA) codes, avoid code-dependent subroutines implementation). An approximate global link to go from Lagrange polynomials to non-uniform-rational-B-splines functions is formulated, which enables the whole FE routines to be untouched during the implementation.

Findings
As a result, only the linear system resolution step is bypassed: the resolution is performed in an external script after projecting the FE system onto the reduced, more regular and isogeometric basis. The novel procedure is successfully validated through different numerical experiments involving linear and nonlinear isogeometric analyses using the standard input/output of the industrial FE software Code_Aster.

Originality/value
A non-invasive implementation of IGA into FEA software is proposed. The whole FE routines are untouched during the novel implementation procedure; a focus is made on the IGA solution of nonlinear problems from existing FEA software; technical details on the approach are provided by means of illustrative examples and step-by-step implementation; the methodology is evaluated on a range of two- and three-dimensional elasticity and elastoplasticity benchmarks solved using the commercial software Code_Aster.
A domain-specific measure of centrality for water distribution networks
Authors: Zarghami Seyed Ashkan , Gunawan Indra 
Published: August 2019

Purpose
In recent years, centrality measures have been extensively used to analyze real-world complex networks. Water distribution networks (WDNs), as a good example of complex networks, exhibit properties not shared by other networks. This raises concerns about the effectiveness of applying the classical centrality measures to these networks. The purpose of this paper is to generate a new centrality measure in order to stick more closely to WDNs features.

Design/methodology/approach
This work refines the traditional betweenness centrality by adding a hydraulic-based weighting factor in order to improve its fit with the WDNs features. Rather than an exclusive focus on the network topology, as does the betweenness centrality, the new centrality measure reflects the importance of each node by taking into account its topological location, its demand value and the demand distribution of other nodes in the network.

Findings
Comparative analysis proves that the new centrality measure yields information that cannot be captured by closeness, betweenness and eigenvector centrality and is more accurate at ranking the importance of the nodes in WDNs.

Practical implications
The following practical implications emerge from the centrality analysis proposed in this work. First, the maintenance strategy driven by the new centrality analysis enables practitioners to prioritize the components in the network based on the priority ranking attributed to each node. This allows for least cost decisions to be made for implementing the preventive maintenance strategies. Second, the output of the centrality analysis proposed herein assists water utilities in identifying the effects of components failure on the network performance, which in turn can support the design and deployment of an effective risk management strategy.

Originality/value
The new centrality measure, proposed herein, is distinct from the conventional centrality measures. In contrast to the classical centrality metrics in which the importance of components is assessed based on a pure topological viewpoint, the proposed centrality measure integrates both topological and hydraulic attributes of WDNs and therefore is more accurate at ranking the importance of the nodes.
Mediating effects of perceived environment support and knowledge sharing between self-efficacy and job performance of SME employees
Authors: Na-Nan Khahan , Saribut Salitta , Sanamthong Ekkasit 
Published: August 2019

Purpose
Currently, small and medium-sized enterprises (SMEs) concentrate on developing their employees’ potential to ensure high job performance. Enhancing the perception of efficacy is important to encourage employees to perform their responsibilities with increased self-confidence. Perceived environmental support and knowledge sharing are also significant factors that boost employees’ potential to achieve targets. The purpose of this paper is to examine how self-efficacy (SE) relates both directly and indirectly to employee job performance through perceived environmental support and knowledge sharing.

Design/methodology/approach
Empirical data were garnered from a sample of 344 admins working at SMEs in Central Thailand and structural equation modelling was used to test the proposed relationships.

Findings
SE had a strong positive influence on employee job performance, perceived environmental support and knowledge sharing, while perceived environmental support and knowledge sharing positively influenced employee job performance. Perceived environmental support and knowledge sharing were considered to be partial mediating factors of SE in the employee job performance model.

Originality/value
This research extends understanding of the relationship between SE and employee job performance. The findings shed light on mediating roles of perceived environmental support and knowledge sharing regarding the relationship between SE and employee job performance.
Assessment of factors affecting maintenance cost of public school facilities
Authors: Hassanain Mohammad A. , Al-Zahrani Mohammad , Abdallah Abdullatif , Sayed Ahmed M.Z. 
Published: August 2019

Purpose
The purpose of this paper is to identify and assess the significance of various factors affecting maintenance costs of public school facilities.

Design/methodology/approach
Detailed literature review resulted in identifying 54 factors that were categorized under nine groups. This was followed by a questionnaire survey completed by 60 experienced professionals. The relative importance index was used to determine the in-group ranking, as well as the overall ranking of these factors.

Findings
The study established that the five most significant factors affecting the maintenance cost of public school facilities were “not providing operations and maintenance manuals to maintenance group” in the “construction phase” category, “ignoring maintainability studies in design” in the “design phase” category, “specification of low-quality materials” in the “design phase” category, “selection criteria of contractors” in the “regulations and contracting” category, and “lack of quality control during work execution” in the “construction phase” category.

Originality/value
The present research represents the first research covering the maintenance cost of public school facilities in Saudi Arabia. The study also presents the unique landscape of facility maintenance in the Saudi Arabian context. The outcome of this research has the potential to significantly cut down unnecessary costs rooted in expensive maintenance of public school facilities, enhancing the quality of these facilities. The findings also underscore the necessity of collaboration and coordination of the various key disciplines toward the realization of cost-effective school facilities.
Micro-level sectoral analysis of developing economies
Authors: Muhtaseb Hind , Khoury Grace , Tovstiga George 
Published: August 2019

PurposeThe purpose of this paper is to examine current performance management practices, identify potential areas of improvement and recommend appropriate interventions. Developing economies continue to intrigue in light of the promise they hold for future growth markets. Existing studies tend to focus on macro-economic factors and to concentrate on a few regions. Few studies have looked at the lesser developed Middle-Eastern regions, such as Palestine. This study seeks to address that deficit; it examines firm-level factors relevant to the competitive performance of enterprises in the Palestinian stone and marble industry, one of the most important industries in the region.Design/methodology/approachThe study utilizes a mixed-methods exploratory qualitative and quantitative approach that probes operational and strategic performance factors. Interviews and insights derived from a survey-based research data from 45 respondents representing a sampling of 36 enterprises form the basis of the analysis.FindingsFindings suggest that the majority of performance measures employed by the firms investigated rely primarily on traditional financial indicators. Although some progressive metrics including those targeting measures of productivity and process efficiency are being adopted by firms in the sector, measures that focus on long-term strategic growth promoters such as innovation and organizational learning are largely not yet employed.Originality/valueThe paper concludes with recommendations for how firms competing in such environments might enhance and improve their performance management.
Cultural influences moderating learners’ adoption of serious 3D games for managerial learning
Authors: Siala Haytham , Kutsch Elmar , Jagger Suzy 
Published: August 2019

PurposeThe purpose of this paper is to investigate whether learners from different cultures adopt a serious 3D game to facilitate the learning of transferable managerial skills (ethics) and knowledge.Design/methodology/approachA cross-sectional, cross-country survey study (n=319) was conducted recruiting participants from one North American and two British universities. The survey data and the conceptual model have been analysed and tested using confirmatory factor analysis and structural equation modelling.FindingsParticipants displayed positive attitudes towards the 3D game and responded positively to theory presented as “real-life” scenarios; gamification techniques such as interactions and dialogue, and rewards and progression levels, which are part of the game, albeit the participants’ adoption was driven more by extrinsic motivations (rewards) than intrinsic ones (ease of use and entertainment). In addition, the empirical results suggest that when gender is taken into account, the perceptions and needs of cross-cultural learners in serious gaming environments vary and display characteristics that are similar to Rogers’ five adopter categories; thus, culture could significantly shape learners’ decisions to adopt a serious game as a managerial learning tool.Research limitations/implicationsFor future researchers, this paper highlights various levels of training, support and promotional awareness that need to be considered to facilitate the adoption of serious games for managerial learning.Practical implicationsFor academics and practitioners in work-based learning and managerial training environments, this paper highlights the salient factors that need to be inherent in a serious 3D game, and best practices for scaffolding existing instructional approaches or training interventions.Originality/valueIn light of Rogers’ five adopter categories, this cross-country study involving culturally diverse learners provides key insight into the potential application of serious games as a practice-based learning instrument in academia and industry.
Growth enterprise market in Hong Kong
Authors: Nguyen Trang , Chaiechi Taha , Eagle Lynne , Low David 
Published: August 2019

Purpose
Growth enterprise market (GEM) in Hong Kong is acknowledged as one of the world’s most successful examples of small and medium enterprise (SME) stock market. The purpose of this paper is to examine the evolving efficiency and dual long memory in the GEM. This paper also explores the joint impacts of thin trading, structural breaks and inflation on the dual long memory.

Design/methodology/approach
State-space GARCH-M model, Kalman filter estimation, factor-adjustment techniques and fractionally integrated models: ARFIMA–FIGARCH, ARFIMA–FIAPARCH and ARFIMA–HYGARCH are adopted for the empirical analysis.

Findings
The results indicate that the GEM is still weak-form inefficient but shows a tendency towards efficiency over time except during the global financial crisis. There also exists a stationary long-memory property in the market return and volatility; however, these long-memory properties weaken in magnitude and/or statistical significance when the joint impacts of the three aforementioned factors were taken into account.

Research limitations/implications
A forecasts of the hedging model that capture dual long memory could provide investors further insights into risk management of investments in the GEM.

Practical implications
The findings of this study are relevant to market authorities in improving the GEM market efficiency and investors in modelling hedging strategies for the GEM.

Originality/value
This study is the first to investigate the evolving efficiency and dual long memory in an SME stock market, and the joint impacts of thin trading, structural breaks and inflation on the dual long memory.