bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL CANCRO DELLO STOMACO CONSIDERAZIONI STATISTICHE E RISULTATI LONTANI
Authors: Umberto Ballarati 
Published: April 2018

A series of 1 035 cases of gastric cancer observed in the Hospital of Busto Arsizio from 1921 to 1953 is presented. 727 patients (70,2 per cent) were operated: 438 of them (42,2 per cent) were submitted to resection, 110 to gastro-enterostomy or gastrotomy, 179 to exploratory laparotomy. The post-operative mortality is of the 18,2 per cent for the totality of operations; for the resections only (radical or sub-radical) a 21,6 per cent mortality is observed. Percentages of 5 and 10 years survival were 18,3 and 13,8 respectively (for patients submitted to radical or palliative resection). For all the treated and untreated patients hospitalized for gastric cancer, the 5 years survival was of the 7,7 per cent.
CARATTERIZZAZIONE DEI COSTITUENTI PROTEICI DEL PERFUSATO DI SARCOMA DI ROUS
Authors: Caputo Antonio 
Published: April 2018

The perfusion fluid, obtained from physiological salt solution circulating in the vascular district of Rous sarcoma, has been electrophoretically examined and ultracentrifuged. The electrophoretic tracings give evidence to four distinct components: their characteristics of mobility and U.V. absorption show that the components 1 and 2 are of nucleoproteic nature, while the components 3 and 4 are of proteic nature (albumins and globulins). The sedimentation diagrams show the presence of two components: one of them represents the 39 per cent and has a S20 = 5,88 × 10−13, the other represents the 61 per cent and has a S20 = 3,84 × 10−13.
L'INFLUENZA DEGLI ORMONI IPOFISARI SULLA CRESCITA DEL CARCINOMA DI WALKER
Authors: Rabotti G. C. 
Published: April 2018

Adult albino rats of the same weight and age were hypophisectomized and grafted with Walker carcinoma. The animals were divided in 8 groups, 4 of which submitted to hormonotherapy and 4 kept as controls. Non hypophisectomized grafted animals submitted to hormonotherapy were also considered as controls. a) in the first group, treated with ACTH, a partial restoration of the tumour growth value was observed in comparison with hypophisectomized untreated animals. b) The same result, though in a lesser degree, was obtained in animals treated with STH. c) the administration of the folliculostimulating hormone (FSH) did not significantly increase the tumour weight. d) the treatment with the interstitial cells stimulating hormone (ICSH) gave the same result of FSH administration. e) animals treated with ACTH and STH showed a remarkable diminution in the ponderal value of the carcass (total weight minus tumour weight) at the end of the experiment.
TUMORI E PROTEINE EMATICHE
Authors: Antonini Francesco Mario , Sodi Amos 
Published: April 2018

The main laboratory investigations for the diagnosis of malignancy are reviewed. None of them has demonstrated to have a sufficient sensibility and specificness. The results of electrophoretic separation of serum proteins of one hundred and twenty eight patients with malignant diseases and of ten patients with benign forms are reported. From the examination of the results we may conclude: a) Eighty five per cent of the patients with malignant diseases has presented alterations of the electrophoretic pattern while no alteration was evident in subjects with benign forms. b) According to what has been already described by others the most frequent alteration seen in subjects with malignant tumors is the increase of alpha 2 globulins. Wo have seen the highest values of alpha 2 globulins in subjects with gastric and pulmonary cancer and in bone metastasis from prostate and breast cancer. c) Hepatic metastasis from gastric cancer presented increase of beta globulins and alpha 2 globulins. In gastric cancer we have very often seen an increase of alpha 1 globulins too. In four cases of gastric cancer (two infiltrating forms and two old gastric ulcers degenerated) we had no modification of serum proteins. d) We had increase of gamma globulins in pulmonary cancer, bone cancer and in the second stage of linphogranuloma. e) The described alterations of the electrophoretic pattern are common to other pathological conditions, out they assume particular importance in tumors of some organs (stomach, lung, bone). f) The insufficient specificness and sensibility of these modification makes them of no value when other pathological conditions are present in the same patient. g) Electrophoretic pattern is very important in the post-operation course (after removal of tumor) as a token of local relapses or metastasis.
« PRIME OSSERVAZIONI CLINICHE ED EMATOLOGICHE SULL'IMPIEGO DELLA SARCOCLORINA NEL TRATTAMENTO DI ALCUNE EMOLINFOPATIE MALIGNE »
Authors: Consoli G. , Violante A. 
Published: April 2018

8 cases of Hodgkin's disease, 1 case of chronic myeloid leukemia and 1 case of reticulosarcoma have been treated with sarcochlorine (DL-para-bis (β-chloroethyl) aminophenylalanine). A marked cytostatic action of the compound, effectively influencing the general conditions, the febrile course and the zonal manifestations of the disease, was observed in all patients. Two negative aspects were demonstrated, i.e. a marked leukopenic influence of the cytostatic substance and a short duration of the clinical remissions.
ASPETTI DOTTRINARI E CLINICI DEL CARCINOMA DELLA MAMMELLA
Authors: Sartori A. 
Published: April 2018

308 malignant tumours of the breast (303 in women and 5 in men) histologically proved, observed in the Surgical Department of the « Ospedale Fatebenefratelli-Sorelle-Ciceri-Agnesi » of Milano from 1941 to 1956 are reported. Out of the 303 cases of the female sex, 301 were epithelial and 2 connectival malignomas. In women, the age distribution showed a highest frequency from 45 to 49 years; the left breast was found to be prevailingly affected (158 cases against 141 in the right breast); 3 cases of bilateral cancer were observed. The most involved quadrant was found to be the supero-external, followed by the supero-internal and the central one. From a clinical point of view, 92 cases were of the I stage, 123 of the II, 78 of the III; in 8 cases the stage was undetermined. Of the 227 cases operated upon, 191 underwent radical mastectomy according to Halsted, followed by postoperative roentgentherapy; 36 (all in the last five years) underwent simple mastectomy with roentgentherapy according to Mc Whirter. Out of the 191 radical cases, 117 showed axillary metastases. A histological differentiation between solid and adeno-carcinoma is of very little practical value, owing to the frequent concomitance of both microscopical features in the same case. Survival percentages in relation to clinical data, pathological findings and treatment could not be established because of the little number of long-term observations after the surgical procedure.
Ricerche Sperimentali Sull'effetto Anticellulare di Alcune Associazioni di Antimitotici su Elementi Proliferanti in Vitro
Authors: Lenti G. , Tortarolo E. , Musolino G. , Girardi F. 
Published: April 2018

The action of some associations of cytostatic agents on « in vitro » embryonic cells are studied: chloramine, deacetylcolchicine and 6-mercapto-purine added with hydrocortisone, and 6-mercapto-purine plus chloramine. The effective doses of each drug were always remarkably lower than those wich were found to have the minimal action in previous researches. It is so demonstrated that this association potentiates the activity of the single drugs. The enhancement varies as for the type and intensity in the different experimented associations. The possibility of a therapeutical application of the cytotoxic combinations is discussed.
RISULTATI DELLA RADIOTERAPIA DEI SARCOMI DELLA FARINGE TRATTATI DAL 1928 AL 1945 (125 CASI)
Authors: Luzzatti G. 
Published: April 2018

125 primary sarcomas of the pharynx, radiologically treated in the years 1928 at 1945 in the Cancer Institute of Milan, have been statistically studied basing: on criteria taking into account the most important clinical and histological data. The evolution of the neoplasms and the results obtained after roentgentherapy will be considered in a second part of the paper.
Correlazione Fra Neoplasie E Gruppi Sanguigni Del Sistema ABO
Authors: Visconti A. , Tolio A. , Cava L. 
Published: April 2018

The relation of cancer to ABO groups was studied in 2590 patients with malignant lesions of different sites (except for gastric tumours), in 171 cases of leukemia, and in 117 cases of Hodgkin's disease. 9607 Mood donors were kept as controls. A prevalence of the A group was observed in tumours of the esophagus (148 cases), of the uterus and ovary (188 cases), in myeloid leukemia (71 cases), and in Hodgkin's disease (117 cases). A prevalence of the 0 group was observed in the 37 patients with lymphatic leukemia. However, A and 0 group prevalence was not found to be statistically significant. No relation to ABO groups was demonstrated in tumours of the colon and rectum (489 cases), larynx (121), lung (806), prostata (111), urinary bladder (120), kidney (71), liver and biliary tract (200), and breast (344). The study of larger series of cases is advised for a better evaluation of the relation between cancer and ABO groups.
L'Asportazione Dei Linfonodi Mammari Interni Nel Trattamento Del Cancro Mammario
Authors: Bucalossi P. 
Published: April 2018

From 1948 to May 1961, 304 patients underwent radical mastectomy with dissection of the internal mammary lymph node chain at the Cancer Institute of Milan. Out of these, 199 were submitted to extrapleural removal of internal mammary lymph nodes, and 105 to an «en bloc » removal, with sterno-costal toracectomy. Of the 305 cases operated upon by the two different techniques, 72 (23.7 %) had internal mammary metastases. The internal mammary involvement was found to be frequent also in tumours of the lateral quadrants (20%). In addition, it could be demonstrated that a relation exists between size of the mammary tumour and frequency of internal mammary metastases. The latter were present in the 15 per cent of tumours less than 3 cm in diameter and in the 61 per cent of tumours 8 cm or more in diameter. Out of the 156 cases with axillary invasion, 54 (41 %) had also internal mammary metastases. Out of the 148 cases without axillary invasion, 7 (4.7 %) had internal mammary metastases. Of the 165 patients operated upon until 1956 (by extrapleural exeresis not «en bloc » with the primary tumour), 91 (55.5 %) were alive after 5 years. The 5-year survival of cases with axillary metastases only was demonstated to be of the 52.4 per cent, whereas it drops to 13.2 per cent in cases with axillary and internal mammary metastases.
Diagnosi Colpocitologica Dell'Adenocarcinoma Dell'Endometrio Dopo Contrazione Provocata
Authors: Di Re F. 
Published: April 2018

The main causes of error (false negatives) in the colpocytologic diagnosis: of endometrial neoplasms are pointed out. A diagnostic method is exposed, which is based on removal by aspiration — under colposcopic control — of the material excreted through the external uterine orifice following uterine contraction induced by i. v. administration of methylergobasine (methergin). The following advantages are obtained with the present method: a) a higher percentage of endometrial cells in the cytologic preparation, b) absence of degenerative phenomena induced by the permanence within the vagina, and c) frequent recovery of small fragments of neoplastic tissue which facilitate the diagnosis. A series of 27 cases of endometrial adenocarcinoma is presented: a positive diagnosis has been attained in 24 cases, and a suspect diagnosis in 1, with an accuracy percentage much higher than that obtained by colpocytologic smears carried out by simple vaginal aspiration. In 20 cases of hyperplastic non-tumoral forms of the endometrium, examined by the same technique, no finding of false positivity has been observed.
Metastasi Ossee Da Neoplasie Dell'Apparato Gastro-Enterico: Studio radiologico
Authors: Dragoni G. , Salvini E. 
Published: April 2018

Out of 2000 primary neoplasms of the digestive system, observed at the Institute of Radiology of the University of Milan, 15 cases of bone localization of metastatic type were encountered. The radiologic diagnosis of metastatic bone changes has been in most cases unexpected, or suspected owing to the presence of a painful symptomatology of the involved skeletal area; these patients are in fact seldom submitted to a complete X-ray examination of the skeleton. The present series includes 6 cases of epithelial neoplasms of the esophagus, 5 of the stomach and 4 of the rectum which, however, do not show particular characteristics of topographic, radiologic or pathologico-anatomical nature. The sites more involved by metastatic changes are the spinal column and the pelvis, that is the most vascular flat bones with anastomotic connections with the Batson's vertebral plexus. Other sites are the scapula, the skull and the long bones. Their radiological appearances are similar to those of the secondary bone changes, with prevalence of osteolytic forms in comparison to osteoplastic ones.
Osservazioni su Generazioni Successive di Tumori Prodotti in Criceti con Inoculo di Cellule Trasformate da SV40
Authors: Menezes José 
Published: April 2018

This paper describes some important features of successive generations of tumors produced in hamsters by inoculation of SV40-transformed cells (C12TSV5 and RHaT), and presents data indicating the correlation among increased percentage of polykaryocytes in the tumor primary cell cultures, increased capacity of cells for fusion, and the production of metastases. According to our knowledge this correlation has not yet been described in tumor biology. The data presented also suggest that the large polykaryocytes from tumor primary cell cultures do not multiply and that they are particularly affected by most experimental procedures. Thus they appear to perish or be drastically reduced in cultures of cells submitted to centrifugation, freezing procedures for routine cells preservation and even trypsination. Our observations also show that cell morphology, SV40 rescuability, and T-antigen appear to be among the features which are not lost in transformed cells throughout in vivo passages. Furthermore, a theory is discussed in an attempt to explain, in part, the local growth of the tumor as well as the occurrence of metastases in the hamster, particularly those at the lymph node level.
Liver and Spleen Scanning in the Study of Malignant Lymphomas
Authors: Buraggi Gian Luigi , Rodari Antonio , Grisotti Giordano , Laurini Roberto 
Published: April 2018

With the object of evaluating the diagnostic importance of liver and spleen scintigraphy in lymphoblastomas, the hepatic and splenic scintigraphic patterns and their actual conditions ascertained through surgical exploration have been compared. 112 scintigraphic tests of liver and 46 of spleen were performed on patients with lymphoma who afterwards underwent splenectomy and multiple hepatic biopsy. Liver scintigraphy provided reliable evidence on the anatomopatological situation of the liver in most cases but also a fair number of false positives, combined sometimes with false negatives, and a large number of doubtful cases. As for as splenic scintigraphy is concerned, there were no positives but a good percentage of false negatives, probably related to the size of the anathomical alterations. In the case of multiple micronodular lesions the limit of scintigraphic detection seems to be about 1 cm. In conclusion, at present, in the case of lymphoblastomas, scintigraphic explorations cannot replace surgical exploration in the appraisal of the diffusion of the disese.
The First Breast Cancer Screening Program in Southern Italy: Preliminary Results from Three Municipalities of the Naples Province
Authors: De Placido Sabino , Nuzzo Francesco , Perrone Francesco , Carlomagno Chiara , Noviello Arturo , Delrio Paolo , Di Palma Ester , Pini Maria Teresa , Cerato Pier Luigi , Bianco Cataldo , Rivellini Maria , Petrella Giuseppe , Gallo Ciro , Sodano Antonio , Bianco Angelo Raffaele 
Published: April 2018

Aims and Background It has been demonstrated that breast cancer screening induces a 30% reduction of specific mortality. In May 1990, we started a pilot screening program to assess the feasibility of carrying out such a program in Campania (southern Italy). Herein we report the results of the first round of the program from three municipalities (Giugliano, Mugnano and Qualiano) that lie within the local health district no. 23, close to the city of Naples. Methods Women between the ages of 50 and 69 years were sent a personalized letter inviting them to attend the screening test; those not responding were sent a second invitation. The screening test consisted of clinical examination followed by two-view mammography. Second–level diagnostic tools were sonography, fine needle aspiration (manual, echo-guided and stereotaxic) and surgical biopsy. Results Out of 5,732 women invited for the first round, 1,813 (31.6%) attended the screening. Attendance rate was higher among younger women. Ninety-one women were positive at the screening test and underwent further examination (recall rate, 5.0%). Among them, 19 had surgical biopsy (biopsy rate, 1.0%) that led to breast cancer diagnosis in 11 cases. The benign/malignant biopsy rate was 0.73. Detection rate was 6.07 × 1,000 screened women and varied among age categories, increasing within the 60–69 subgroup; detection rate/expected incidence ratio in the overall group was 4.5 and also increased within the older age category. Seven out of 11 cancers were at UICC stage 0-I. Among 327 self-referring women, 38 were positive (recall rate, 11.6%), and 14 underwent biopsy (biopsy rate, 4.3%), which showed cancer in 7 cases (benign/malignant biopsy rate, 1.0). In addition, 2 inflammatory cancers were diagnosed without surgical biopsy. Thus 9 cancer cases were detected in this group. Self-referring women differed from responding women in that they had a higher frequency of symptoms or familiar history of cancer, and a higher educational level and awareness of preventive medicine. Clinical examination added no diagnostic advantage in the responding group but did not significantly worsen the recall rate. In the self-referring group, one case of inflammatory cancer was missed by mammography and diagnosed by clinical examination. Conclusion The early results (recall rate = 5%, detection rate/expected incidence ratio = 4.5, benign/malignant biopsy rate = 0.73, advanced cancers = 36.4%) are encouraging and indicate the validity of the program. Strategies to improve attendance rate are planned.
Carbon Dioxide Digital Subtraction Angiography in Oncological-Interventional Radiology
Authors: Garbagnati Francesco , Spreafico Carlo , Marchianò Alfonso , Frigerio Laura Francesca , Patelli Gianluigi , Gervasoni Maria , Giovannardi Giulia , Damascelli Bruno 
Published: April 2018

Aims and background The aim of this work is to demonstrate the usefulness of carbon dioxide, used as contrast agent, in special indications in vascular interventional oncological procedures. Methods We studied 40 patients with digital subtraction angiography enhanced with CO2 as a contrast agent. At the same time we utilized also, in all cases, jodinated contrast agent to evaluate the different opacification gradient, the different viscosity range and the different perfusion. Results The low viscosity of CO2 allows demonstration of the presence of even minimal blood losses in gastrointestinal tumors and enhances arteriovenous shunts in hepatocellular carcinoma. Carbon dioxide can also be employed to assess the patency of small-sized catheters for chemotherapy infusion which do not allow easy injection of the traditional iodinated contrast agents characterized by high viscosity. Conclusion Carboangiographic study combined to digital subtraction angiography can clear some diagnostic problems and is further method to assess the outcome of angiographic interventional procedures in oncology.
The Potential Role of Tomudex in the Treatment of Advanced Colorectal Cancer
Authors: Sobrero Alberto F. 
Published: April 2018

Aims and Background The quinazoline folate analog thymidylate synthase inhibitor, Tomudex, is about to enter the Italian pharmaceutical market. Its place among the therapeutic options for advanced colorectal cancer is discussed. Methods The pros and cons of currently available chemotherapeutic regimens are briefly described with special attention to patient's and tumor's determinants of treatment outcome. The mechanism of action and the results of phase I, II and III studies of Tomudex are reviewed. Results Not all patients need to be treated. Guidelines are given in this respect. Tomudex at the dose of 3 mg/m2 given i.v. every three weeks has antitumor activity similar to that of currently available regimens, with a favorable toxicity profile. Conclusions Current research approaches are unlikely to dramatically improve the treatment outcome of this disease in the near future. What can reasonably be expected is less toxicity and more convenient routes and schedules of drug administration that may translate into better quality of life for our patients. Tomudex has been devised along these lines.
Frequency of Thyroid Carcinoma in a Recent Series of 539 Consecutive Thyroidectomies for Multinodular Goiter
Authors: Pelizzo Maria Rosa , Bernante Paolo , Toniato Antonio , Fassina Ambrogio 
Published: April 2018

Aims and background The aim of the study was to analyze the frequency of thyroid carcinoma in a consecutive series of 539 thyroidectomies for multinodular goiter (MNG) and to assess the influence of sex and age as cancer risk factors. Methods In a 2-year period, 539 patients underwent subtotal or total thyroidectomy for MNG at the Institute of General Surgery, University of Padova, Padova, Italy: 455 were females and 84 males (F/M = 5.5/1); mean age was 46 years (min. 17, max 78). Only 17 patients (3.1%) (16 females and 1 male) were aged 21 years or less. Results A malignancy was found in 41 patients: 38 females and 3 males; 39 older and 2 younger than 21 years. The frequency of cancer in MNG was 7.6%: 8.3% in females and 3.6% in males; 7.5% in patients older than 21 and 11.7% under 21 years. Conclusions The combination of MNG and carcinoma should always be carefully considered but not overemphasized, and the policy of surgically treating all patients with MNG is not justified. Sex and age cannot be considered as factors of a higher risk of cancer.
Lack of Prognostic Value of p53 Protein Expression in Node-Negative Breast Cancer
Authors: Bianchi Simonetta , Calzolari Anna , Vezzosi Vania , Zampi Giancarlo , Cardona Gaetano , Cataliotti Luigi , Bonardi Rita , Ciatto Stefano 
Published: April 2018

Aims and background The association of p53 protein accumulation and prognosis in node-negative breast cancer patients has been alternately demonstrated and denied in literature reports, and opinions on the use of p53 expression as an indicator of high risk of recurrence and as a guide for adjuvant therapy are controversial. Study design The association of p53 protein accumulation with prognosis was retrospectively evaluated in a series of 221 node-negative breast cancer patients treated with surgery alone and followed up for a minimum of 10 years. p53 accumulation was determined by immunohistochemistry on archive material, and classified into four grades of increasing immunostaining. Results No association was observed between p53 and age or pT category, whereas a significant association with nuclear grade was found (P = 0.0014). Univariate and multivariate analysis of 10-yr disease-free and overall survival showed a significant and independent prognostic association for tumor size (pT category) and nuclear grading but not for p53 expression, whatever grade grouping was used. Conclusions We did not find any evidence supporting the use of p53 immunostaining in current practice as an independent prognostic indicator or as a discriminant factor for adjuvant treatment of node-negative breast cancer patients.