bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of saffron (Crocus sativus L.) supplementation on cardiometabolic Indices in diabetic and prediabetic overweight patients: a systematic review and meta-analysis of RCTs
Authors: Karim Mehdi , Pirzad Samira , Shirsalimi Niyousha , Hosseini Mohammad Hossein , Ebrahimi Pouya , khoshdooz Sara , Rashidian Pegah 
Published: November 2024

Abstract
Background
The incidence of diabetes mellitus (DM) is increasing worldwide, and there is growing interest in the potential use of natural compounds as an alternative treatment for managing DM. Several research studies have investigated the impact of saffron consumption on managing and improving metabolic profiles in patients with DM, and they have shown promising results.

Object
The study aims to systematically review and perform a meta-analysis to evaluate the potential effects of saffron and its extract on cardiometabolic indicators in diabetic and prediabetic overweight patients.

Methods
We conducted a comprehensive systematic review and meta-analysis, searching PubMed, Scopus, Web of Science, Embase, and Google Scholar for all relevant studies published before April 20, 2024. We extracted weighted (WMD) or standardized (SMD) mean differences (before-after) and 95% confidence intervals (95%CI) of the outcomes and conducted meta-analyses using R. The study protocol was registered in PROSPERO (CRD42024538380).

Results
Out of the studies screened, 15 RCTs were selected for inclusion in the systematic review and meta-analysis. These studies collectively involved 869 participants, 438 in the intervention group and 431 in the control group. Notably, our results showed that saffron supplementation led to significant changes in FBS (MD: − 8.75 mg/dL, 95% CI [− 14.75; − 2.76], P < 0.01), HbA1C (MD: − 0.34%, 95% CI [− 0.39; − 0.9], P < 0.01), TG (MD: − 13.28 mg/dL, 95% CI [− 22.82; − 3.75], P < 0.01), SBP (MD: − 5.33 mmHg, 95% CI [− 8.99–1.67], P = 0.04), DBP (MD: − 1.02 mmHg, 95% CI [− 3.91; 1.86], P = 0.03), AST (MD: − 1.32 IU/L, 95% CI [− 1.72, − 0.93], P < 0.01) levels in T2DM patients compared to placebo or no supplementation, indicating its potential as a therapeutic intervention. However, there was no significant effect on Insulin secretion (MD: − 0.15 µU/ml, 95% CI [− 2.1763; 1.8689], P = 0.88), HOMA (MD: − 0.35%, 95% CI [− 1.34;0.63], P = 0.48), TC (MD: − 4.86 mg/dL, 95% CI [− 9.81–0.09], P = 0.54), HDL (MD: 0.18 mg/dL, 95% CI [− 0.93; 1.29], P = 0.74), LDL (MD: − 1.77 mg/dL, 95% CI [− 5.99–2.45], P = 0.41), TNF-α (MD: − 0.34 pg/mL, 95% CI [− 0.99–0.30], P = 0.29), creatinine (MD: 2.83 mg/dL, 95% CI [2.29, 3.37], P = 0.31) and BUN (MD: − 0.44 mg/dL, 95% CI [− 1.43, 0.55], P = 0.38).

Conclusion
Saffron may improve specific CMI indices in overweight patients with diabetes or prediabetes, including significant reductions in FBS, HbA1C, TG, SBP, and AST. However, it did not significantly affect HDL, TC, LDL, insulin secretion, HOMA, DBP, TNF-α, ALT, Cr, or BUN. Further research with more trials and extended follow-up periods is needed to confirm and expand these findings.
Assessing multi-target antiviral and antioxidant activities of natural compounds against SARS-CoV-2: an integrated in vitro and in silico study
Authors: Al balawi Aisha Nawaf , Eldiasty Jayda G. , Mosallam Sahar Abd-El Razik , El-Alosey Alaa R. , Elmetwalli Alaa 
Published: November 2024

AbstractThere is an urgent need for preventive and therapeutic drugs to effectively treat and prevent viral diseases from resurfacing as they emerge during the COVID-19 pandemic. This study aims to assess the antiviral effects of four natural compounds commonly used in traditional medicine to treat SARS-CoV-2 infection. A cytotoxicity, dose-dependent, and plaque reduction assay was performed on Vero CCL-81 cells to figure out their effects on the cells. Quantification of cytokines was assessed. In silico analysis for the selected compound was also evaluated. Results revealed that the compounds could disrupt the viral replication cycle through direct inhibition of the virus or immune system stimulation. The cytotoxicity assay results revealed that the compounds were well tolerated by the cells, indicating that the compounds were not toxic to the cells. This study evaluated the antioxidant capacities of propolis, curcumin, quercetin, and ginseng using ABTS, FRAP, and CUPRAC assays, revealing that propolis exhibited the highest antioxidant activity of ABTS with 1250.40 ± 17.10 μmol Trolox eq/g, with FRAP values reaching 1200.55 ± 15.90 μmol Fe2⁺ eq/g and CUPRAC values of 1150.80 ± 14.20 μmol Trolox eq/g at 1000 µg/mL, highlighting its potential as a potent natural antioxidant. The results of the plaque reduction assay revealed that the compounds could reduce the size and number of plaques, indicating that the compounds could inhibit the virus replication cycle. Subsequently, using molecular docking to analyze the effect of propolis, curcumin, quercetin, and ginseng as inhibitors, it was unveiled that the four compounds are likely to have the potential to inhibit the protease activity, spike protein S1, and RNA polymerase of SARS-CoV-2 and the virus titer was reduced by 100% after post-infection using propolis as an inhibitor control.
Graphical Abstract
Exploring factors influencing university students’ intentions to use ChatGPT: analysing task-technology fit theory to enhance behavioural intentions in higher education
Authors: Al-Mamary Yaser Hasan , Alfalah Adel Abdulmohsen , Alshammari Mohammad Mulayh , Abubakar Aliyu Alhaji 
Published: November 2024

AbstractThe increasing integration of AI technologies such as ChatGPT in educational systems calls for an in-depth understanding of the factors influencing students’ intentions to use these tools. This study explores the factors shaping university students’ intentions to use ChatGPT by analysing three key dimensions: task characteristics, technology characteristics and individual characteristics. Using the task-technology fit (TTF) framework, the research examined how these elements impact the alignment between educational tasks and ChatGPT’s capabilities, ultimately driving students’ behavioural intentions. A survey of 393 students from a Saudi Arabian university was conducted, and structural equation modelling was applied to assess the relationships among the variables. Results indicated that all three characteristics significantly influenced TTF, which in turn had a positive impact on students’ intentions to use ChatGPT. The study highlighted the importance of achieving a strong TTF to encourage the effective use of AI tools in academic settings. The implications of this research suggest that educational institutions should focus on aligning AI technologies with students’ learning tasks to enhance their intent to use these tools, thereby improving academic performance. Furthermore, this study extended the TTF model to the context of AI-powered educational tools, particularly in line with Saudi Arabia’s Vision 2030. This research is one of the first to investigate the factors influencing students’ intentions to use ChatGPT within the unique cultural and technological context of Saudi Arabia’s higher education system. By integrating the TTF framework with local and regional factors, the study provides novel insights into the drivers of AI usage in education, offering guidance for regional policy and broad educational practices.
Strengthening the relationship between community resilience and health emergency communication: a systematic review
Authors: Vandrevala Tushna , Morrow Elizabeth , Coates Tracey , Boulton Richard , Crawshaw Alison F. , O’Dwyer Emma , Heitmeyer Carrie 
Published: November 2024

Abstract
Background
Community resilience and health emergency communication are both crucial in promoting a community’s ability to endure crises and recover from emergency events. Yet, a notable gap in theory and evidence exists in the relationship between them. We aim to explore the relationship between community resilience and health emergency communication and to identify strategies and interventions to strengthen their usefulness to each other. Based on the results, a secondary aim was to develop a model of community-centred resilience and health emergency communication.

Methods
A systematic review of literature published between January 1990 and February 2024 was undertaken following Joanna Briggs Institute guidelines. Electronic databases (Web of Science, Social Science Citation Index, PubMed/MEDLINE) were searched using key terms. Eligibility criteria were developed from the literature and the knowledge of the multidisciplinary team. Inductive thematic analysis generated key themes. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were applied to present the findings.

Results
The searches identified 300 articles, of which 86 met the inclusion criteria. Two main themes were identified from the literature: (i) the relationship between emergency communication and community resilience, including subthemes: building trust and collaboration within communities, identifying resources and their distribution, tailoring communication strategies, considering inclusion and equity, and community engagement and feedback and (ii) strategies and interventions, including subthemes: facilitating community structures as channels for communication, respecting personal and private boundaries in health communication, targeting outreach for effective crisis communication, building resilience through training and communication initiatives, and demonstrating commitment to equity and inclusion.

Conclusions
There is a small, yet valuable, body of evidence to demonstrate the value of bolstering community-centred resilience for emergency preparedness, response and recovery. The model of community-centred resilience and health emergency communication developed can inform policy, research and practice. Further research is required to develop and test community-centred approaches to enhance inclusive risk communication and equitable recovery.
Gender, Rumor, and Religious Polemic in Louis XIV's France
Authors: Heath Sean 
Published: November 2024

Abstract
The Chinese Rites Controversy was one of the most contentious issues in the French church at the beginning of the eighteenth century. Nourished with rumors from China, it was predominantly a debate among men, with the exception of an extraordinary intervention by a woman, Paule Payen de Lionne, in 1701. In a public letter to the Jesuits, she used a dispute concerning her missionary son Artus de Lionne to launch a fierce critique of what she saw as the Society of Jesus's toleration of Chinese idolatry. Conscious that many would see it as inappropriate for a woman to discuss a matter of ecclesiastical controversy, Payen nonetheless filled the letter with references to her sex. This article proposes that she strategically invoked tropes of feminine weakness and intellectual inadequacy as rhetorical tools to contrast the simple purity (and thus truth) of her perspective with the verbose artifice of the Jesuits. At the same time, the register of aggression in her letter forces historians to reconsider the view that women engaging in querelles were obliged to adopt a less confrontational tone than men. This episode shows how women could use femininity to carve out a unique voice in an otherwise male-dominated public sphere.
Dividing small groups into problem-based learning tutorials: an experience report
Authors: Sousa Costa Henrique , Mendes do Carmo Julia , Ademar Dias Arruda Filho Carlos , Pedrosa Moreira Deborah , Da Silva Rodrigues Maria Dilene , Kubrusly Marcos 
Published: November 2024

This article aims to provide a critical and reflective account of the experience of the pedagogical support service at the Christus University Center - Unichristus, during the implementation of the heterogeneous division of tutorial groups by personality traits, in the active methodology, Problem-Based Learning (PBL). Method: This is a descriptive experience report of a study carried out at a private higher education institution in Fortaleza. The participants were 12 teachers who acted as tutors and 120 students who were new to the PBL methodology. The activity was systematized into three moments: application of the QUATI psychological typology test to the students, classification of the students into extroversion and introversion attitudes, division of the tutorial groups into similar proportions of introverted and extroverted students. The educational action involved training the teachers in group dynamics, revealing the personalities of their respective students and a round table discussion after the end of the semester. Results: the heterogeneous division of groups and teacher training led to an improvement in the management of tutorial groups. Conclusion: the experience showed that the tutors' prior knowledge of the personality traits of the tutorial group members and their heterogeneous formation can contribute to improving the teaching-learning process in PBL, especially with regard to looking at existing personalities individually.
Warsztat artysty malarza w XVIII stuleciu na przykładzie dzieł Szymona Czechowicza (1689−1775) oraz twórców jego kręgu
Authors: Doleżyńska-Sewerniak Ewa 
Published: November 2024

Niniejsza publikacja poświęcona jest zagadnieniom warsztatu malarskiego artystów w XVIII stuleciu, ze szczególnym uwzględnieniem Szymona Czechowicza − jednego z najwybitniejszych polskich twórców aktywnych w tym czasie. Głównym celem badań była rekonstrukcja procesu twórczego − etapów i metod realizacji obrazów oraz technicznej strony malarstwa, a także przybliżenie realiów tego zawodu: edukacji, organizacji pracy, pracowni, jej zasobu − używanych narzędzi, materiałów i akcesoriów, a także ich dostępności.

Dzięki temu autorka stworzyła bank danych dotyczących metod i materiałów w warsztacie Czechowicza, które – być może − staną się bazą do porównań, ułatwiającą datowanie oraz służącą weryfikacji autorstwa przypisywanych mu prac. Jako że badania objęły także obrazy artystów związanych z jego pracownią (tych znanych z nazwiska), autorka podjęła próbę opisania wpływu Szymona Czechowicza na ukształtowanie ich warsztatu.
Descolonização das disciplinas acadêmicas na formação de professores
Authors: Araujo da Silva Andréa Giordanna 
Published: November 2024

O artigo aborda o processo de desenvolvimento de práticas e de conteúdos descolonizadores no âmbito da educação superior. Constitui-se da análise do movimento político-pedagógico crítico de reconstrução do currículo universitário de forma endógena, a partir da invenção de outras práticas e da circulação de outros saberes na ministração das disciplinas obrigatórias do curso de formação inicial de professores(as). Trata das especificidades do curso de licenciatura em Pedagogia do Campo, ofertado por uma universidade federal da região Nordeste do Brasil. O estudo documental e qualitativo observou que o contato de diferentes grupos étnicos, culturais e sociais, com interesses políticos e culturais semelhantes, fez insurgir, nas(os) futuras(os) professoras(es), o interesse pelo desenvolvimento de saberes e práticas que confrontam o modelo colonizador de formação acadêmica na educação superior.

[1] Como maior parte do corpo discente do curso de Pedagogia é feminino, utiliza-se este gênero como primazia na escrita.
Parallel 3D projection lithography of massive tunable nanopillars for functional structures
Authors: Su Chenyi , Yang Shunhua , Ding Chenliang , Wen Jisen , Yang Zhenyao , Zhang Jiachen , Xu Liang , Shi Junhui , Kuang Cuifang , Liu Xu 
Published: November 2024

As a typical nanostructure, nanopillars enable multiple functional
structures. However, fabricating nanopillar arrays of large scale and
varying sizes is challenging for conventional manufacturing methods.
This paper presents a parallel 3D projection lithography that
generates 5041 programmable and extended-focal-depth foci for the 3D
projection of massive size- and period-tunable nanopillars. Nanopillar
arrays of various sizes can be printed by tuning the intensity or the
exposure time of each focus. The high aspect ratios of 11.6 and 18.7
are obtained by serial in situ exposure
and z-axis scanning, respectively.
Large-scale superhydrophobic surfaces with various periods are printed
via multiple interlaced exposures, and a maximum contact angle of
167.4° is obtained. The fabricated dynamic self-assembly nanopillars
can be controlled by precisely adjusting the intervals or modifying
the developing process. Furthermore, metalenses operating at 532 nm
with a maximum diameter of 10 mm are designed and fabricated by
stitch-free and 3D-grayscale exposure, and their focusability and
focal length are verified. The results have well demonstrated the
superiority of our scheme for the simultaneous realization of
ultrahigh-throughput, volume-exposure, individually controlled, and
high-precision grayscale nanofabrication for functional
structures.
The relationship between democracy and corruption and the global physician workforce
Authors: Kirpalani Amrit , Yilmaz Eray 
Published: November 2024

Background
Understanding how governance factors such as democracy and corruption impact the healthcare workforce is crucial for achieving Universal Health Coverage (UHC). Effective health workforce planning and resource allocation are influenced by these political constructs. This study examines the relationship between democracy and corruption and key healthcare workforce metrics.

Methods
A cross-sectional study was conducted using a global dataset from 2020 to 2022. The primary outcome was Physician Density (medical doctors per 10000 people). Secondary outcomes included the generalist to specialist ratio and the percentage of female physicians (% Female). Partial correlations, multivariate analysis of variance (MANOVA), and univariate analysis of variance (ANOVA) were used to analyze the relationship between workforce variables and the democracy index (DI), and corruption perception index (CPI), controlling for domestic health expenditure.

Results
Data from 134 countries showed significant positive associations between both DI (r = 0.32, p = 0.004) and CPI (r = 0.43, p < 0.001) with physician density. MANOVA indicated significant multivariate effects of DI (Wilks’ Lambda = 0.8642, p = 0.013) and CPI (Wilks’ Lambda = 0.8036, p = 0.001) on the combined workforce variables. Univariate ANOVAs showed that DI (F = 6.13, p = 0.015) and CPI (F = 10.57, p = 0.002) significantly affected physician density, even after adjusting for domestic expenditure (F = 18.53, p < 0.001). However, neither DI nor CPI significantly impacted the Generalist to Specialist Ratio or % Female Physicians.

Discussion
Higher levels of democracy and lower levels of corruption are associated with a greater density of medical doctors, independent of healthcare spending. Policymakers must advocate for governance reforms that support a robust healthcare workforce to support aim of universal health coverage.
An immune suppressive tumor microenvironment in primary prostate cancer promotes tumor immune escape
Authors: Anton Angelyn , Hutchinson Ryan , Hovens Christopher M. , Christie Michael , Ryan Andrew , Gibbs Peter , Costello Anthony , Peters Justin , Neeson Paul J. , Corcoran Niall M. , Tran Ben 
Published: November 2024

Background
Immunotherapy has demonstrated limited activity in prostate cancer to date. This likely reflects an immune suppressive tumor microenvironment (TME), with previous studies suggesting low PD-L1 expression and a sparse immune cell infiltrate. We aimed to further characterise the immune TME in primary prostate cancer and correlate immune subset densities with clinical outcomes.

Methods
Two distinct cohorts of patients treated with radical prostatectomy were identified, based on the development of biochemical recurrence (BCR), one subgroup with high International Society of Urological Pathologists (ISUP) grade group, recurrent disease and a second with low grade, non-recurrent disease. A prostate immunohistochemical (IHC) antibody cocktail was used to differentiate tumor and peritumoral benign tissue. Specific CD8+, CD4+, FoxP3+, CD20+ and CD68+ cell subsets were identified using IHC staining of consecutive slides. PD-L1 and CD8/PD-L1 dual staining were also performed. Cell subset densities were quantified within tumor and peritumoral regions. We used descriptive statistics to report cell subset densities and T-tests to compare groups by age, grade and the development of BCR. Univariable and multivariable logistic regression were used to analyse risk factors for BCR and the development of metastatic disease.

Results
A total of 175 patients were included, with a median age of 63 years and median pre-operative PSA of 8.2ng/ml. BCR occurred in 115 patients (66%) and 56 (32%) developed metastatic disease. CD68+ cells were the most abundant (median 648.8/mm2 intratumoral, 247.6/mm2 peritumoral), while PD-L1+ and PD-L1/CD8+ cell density was low overall (PD-L1+ median 162.4/mm2 intratumoral, 141.7/mm2 peritumoral; PD-L1/CD8+ (median 5.52/mm2 intratumoral, 3.41/mm2 peritumoral). Overall, grade group and T-stage were independently associated with BCR and metastatic disease. Higher density of peritumoral PD-L1+ cells was an independent risk factor for BCR (OR 5.33, 95%CI 1.31–21.61, p = 0.019).Although higher densities of CD8+ and CD4+ cells were observed in higher grade group 3–5 tumors, these were not associated with the development of BCR or metastasis.

Conclusions
In our cohort of prostate cancer patients who underwent radical prostatectomy, higher grade group and T-stage were independent predictors of BCR and metastasis. Despite higher grade group being associated with higher CD8+ cell density, PD-L1+ and PD-L1/CD8+ cell densities were low overall, suggesting lower T cell receptor recognition of tumor antigens. Further understanding of this phenomenon would influence development of future immunotherapeutic strategies in prostate cancer.
The relationship between proactive personality and college students’ short-form video addiction: A chain mediation model of resilience and self-control
Authors: Wu Shujie , Shafait Zahid , Bao Kaixin 
Published: November 2024

Background
With the explosive development of the short-form video (SFV) industry in recent years, the issue of SFV addiction among young people has attracted increasing attention from scholarship. Researchers have found that proactive personality is negatively associated with behavioral addiction. Additionally, SFV Apps tend to place users in a “filter bubble” to passively consume the pushed video content. Proactiveness could be an effective trait to resist the excessive use of SFVs. Thus, proactive personality may be a negative predictor of SFV addiction.

Objective
The present study aims at investigating the relationship between proactive personality and SFV addiction among college students, and the psychological mechanism underlying the relationship, i.e., the mediating roles of resilience and self-control.

Methods
Convenience sampling was adopted to conduct an online questionnaire survey among college students from 8 universities in 5 provinces of China. Proactive personality scale (PPS), brief resilience scale (BRS), Brief self-control scale (BSCS), and SFV addiction scale were applied in designing the questionnaire. A total of 560 valid questionnaires were obtained with ages ranging from 17 to 22 (19.32±1.14), among whom 40.18% were males and 59.28% females.

Results
SFV addiction among college students was negatively correlated with proactive personality, resilience, and self-control. Proactive personality has significant direct effect on SFV addiction, and the other two variables play partial mediating roles including chain mediation between proactive personality and SFV addiction. The ratio of SFV addicts amounted to 23.57%, which was slightly higher compared to previous research findings.

Conclusion
Proactive personality negatively predicts SFV addiction among college students and the mediators of resilience and self-control play partially mediating roles between proactive personality and SFV addiction.