bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence and reliability of lower-limb arterial occlusion pressure at different body positions
Authors: Hughes Luke , Jeffries Owen , Waldron Mark , Rosenblatt Ben , Gissane Conor , Paton Bruce , Patterson Stephen D. 
Published: May 2018

Background
Total arterial occlusive pressure (AOP) is used to prescribe pressures for surgery, blood flow restriction exercise (BFRE) and ischemic preconditioning (IPC). AOP is often measured in a supine position; however, the influence of body position on AOP measurement is unknown and may influence level of occlusion in different positions during BFR and IPC. The aim of this study was therefore to investigate the influence of body position on AOP.

Methods
Fifty healthy individuals (age = 29 ± 6 y) underwent AOP measurements on the dominant lower-limb in supine, seated and standing positions in a randomised order. AOP was measured automatically using the Delfi Personalised Tourniquet System device, with each measurement separated by 5 min of rest.

Results
Arterial occlusive pressure was significantly lower in the supine position compared to the seated position (187.00 ± 32.5 vs 204.00 ± 28.5 mmHg, p < 0.001) and standing position (187.00 ± 32.5 vs 241.50 ± 49.3 mmHg, p < 0.001). AOP was significantly higher in the standing position compared to the seated position (241.50 ± 49.3 vs 204.00 ± 28.5 mmHg, p < 0.001).

Discussion
Arterial occlusive pressure measurement is body position dependent, thus for accurate prescription of occlusion pressure during surgery, BFR and IPC, AOP should be measured in the position intended for subsequent application of occlusion.
A novel RNA sequencing‐based miRNA signature predicts with recurrence and outcome of hepatocellular carcinoma
Authors: Bai Fumao , Zhou Huaibin , Ma Mengni , Guan Chen , Lyu Jianxin , Meng Qing H. 
Published: May 2018

Hepatocellular carcinoma (HCC) is the fifth most common type of cancer and the second leading cause of cancer‐related deaths worldwide. Given that the rate of HCC recurrence 5 years after liver resection is as high as 70%, patient with HCC typically has a poor outcome. A biomarker or set of biomarkers that could predict disease recurrence would have a substantial clinical impact, allowing earlier detection of recurrence and more effective treatment. With the aim of identifying a new microRNA (miRNA) signature associated with HCC recurrence, we analyzed data on 306 patients with HCC for whom both miRNA expression profiles and complete clinical information were available from The Cancer Genome Atlas database. Through this analysis, we identified a six‐miRNA signature that could effectively predict patients’ recurrence risk; the high‐risk and low‐risk groups had significantly different recurrence‐free survival rates. Time‐dependent receiver operating characteristic analysis indicated that this signature had a good predictive performance. Multivariable Cox regression and stratified analyses demonstrated that the six‐miRNA signature was independent of other clinical features. Functional enrichment analysis of the gene targets of the six prognostic miRNA indicated enrichment mainly in cancer‐related pathways and important cell biological processes. Our results support use of this six‐miRNA signature as an independent factor for predicting recurrence and outcome of patients with HCC.
Rho‐kinase inhibitors do not expand hematoma volume in acute experimental intracerebral hemorrhage
Authors: Akhter Murtaza , Qin Tom , Fischer Paul , Sadeghian Homa , Kim Hyung Hwan , Whalen Michael J. , Goldstein Joshua N. , Ayata Cenk 
Published: May 2018

AbstractRho‐associated kinase (ROCK) is an emerging target in acute ischemic stroke. Early pre‐hospital treatment with ROCK inhibitors may improve their efficacy, but their antithrombotic effects raise safety concerns in hemorrhagic stroke, precluding use prior to neuroimaging. Therefore, we tested whether ROCK inhibition affects the bleeding times, and worsens hematoma volume in a model of intracerebral hemorrhage (ICH) induced by intrastriatal collagenase injection in mice. Tail bleeding time was measured 1 h after treatment with isoform‐nonselective inhibitor fasudil, or ROCK2‐selective inhibitor KD025, or their vehicles. In the ICH model, treatments were administered 1 h after collagenase injection. Although KD025 but not fasudil prolonged the tail bleeding times, neither drug expanded the volume of ICH or worsened neurological deficits at 48 h compared with vehicle. Although more testing is needed in aged animals and comorbid models such as diabetes, these results suggest ROCK inhibitors may be safe for pre‐hospital administration in acute stroke.
Long‐Lived and Highly Efficient TADF‐PhOLED with “(A)n–D–(A)n” Structured Terpyridine Electron‐Transporting Material
Authors: Bian Mengying , Zhang Dongdong , Wang Yuanxun , Chung Yao‐Hsien , Liu Yang , Ting Hungkit , Duan Lian , Chen Zhijian , Bian Zuqiang , Liu Zhiwei , Xiao Lixin 
Published: May 2018

AbstractThe electron‐transporting material (ETM) is one of the key factors to determine the efficiency and stability of organic light‐emitting diodes (OLEDs). A novel ETM with a “(Acceptor)n–Donor–(Acceptor)n” (“(A)n–D–(A)n”) structure, 2,7‐di([2,2′:6′,2″‐terpyridin]‐4′‐yl)‐9,9′‐spirobifluorene (27‐TPSF), is synthesized by combining electron‐withdrawing terpyridine (TPY) moieties and rigid twisted spirobifluorene, in which the TPY moieties facilitate electron transport and injection while the spirobifluorene moiety ensures high triplet energy (T1 = 2.5 eV) as well as enhances glass transition temperature (Tg = 195 °C) for better stability. By using tris[2‐(p‐tolyl)pyridine]iridium(III) (Ir(mppy)3) as the emitter, the 27‐TPSF‐based device exhibits a maximum external quantum efficiency (ηext, max) of 24.5%, and a half‐life (T50) of 121, 6804, and 382 636 h at an initial luminance of 10 000, 1000, and 100 cd m−2, respectively, which are much better than the commercialized ETM of 9,10‐bis(6‐phenylpyridin‐3‐yl)anthracene (DPPyA). Furthermore, a higher efficiency, a ηext, max of 28.2% and a maximum power efficiency (ηPE, max) of 129.3 lm W−1, can be achieved by adopting bis(2‐phenylpyridine)iridium(III)(2,2,6,6‐tetramethylheptane‐3,5‐diketonate) (Ir(ppy)2tmd) as the emitter and 27‐TPSF as the ETM. These results indicate that the derivative of TPY to form “(A)n–D–(A)n” structure is a promising way to design an ETM with good comprehensive properties for OLEDs.
Thermoreversible Hyaluronic Acid‐PNIPAAm Hydrogel Systems for 3D Stem Cell Culture
Authors: Ekerdt Barbara L. , Fuentes Christina M. , Lei Yuguo , Adil Maroof M. , Ramasubramanian Anusuya , Segalman Rachel A. , Schaffer David V. 
Published: May 2018

AbstractHuman pluripotent stem cells (hPSCs) offer considerable potential for biomedical applications including drug screening and cell replacement therapies. Clinical translation of hPSCs requires large quantities of high quality cells, so scalable methods for cell culture are needed. However, current methods are limited by scalability, the use of animal‐derived components, and/or low expansion rates. A thermoresponsive 3D hydrogel for scalable hPSC expansion and differentiation into several defined lineages is recently reported. This system would benefit from increased control over material properties to further tune hPSC behavior, and here a scalable 3D biomaterial with the capacity to tune both the chemical and the mechanical properties is demonstrated to promote hPSC expansion under defined conditions. This 3D biomaterial, comprised of hyaluronic acid and poly(N‐isopropolyacrylamide), has thermoresponsive properties that readily enable mixing with cells at low temperatures, physical encapsulation within the hydrogel upon elevation at 37 °C, and cell recovery upon cooling and reliquefaction. After optimization, the resulting biomaterial supports hPSC expansion over long cell culture periods while maintaining cell pluripotency. The capacity to modulate the mechanical and chemical properties of the hydrogel provides a new avenue to expand hPSCs for future therapeutic application.
Direct Electrical Neurostimulation with Organic Pigment Photocapacitors
Authors: Rand David , Jakešová Marie , Lubin Gur , Vėbraitė Ieva , David‐Pur Moshe , Đerek Vedran , Cramer Tobias , Sariciftci Niyazi Serdar , Hanein Yael , Głowacki Eric Daniel 
Published: May 2018

AbstractAn efficient nanoscale semiconducting optoelectronic system is reported, which is optimized for neuronal stimulation: the organic electrolytic photocapacitor. The devices comprise a thin (80 nm) trilayer of metal and p–n semiconducting organic nanocrystals. When illuminated in physiological solution, these metal–semiconductor devices charge up, transducing light pulses into localized displacement currents that are strong enough to electrically stimulate neurons with safe light intensities. The devices are freestanding, requiring no wiring or external bias, and are stable in physiological conditions. The semiconductor layers are made using ubiquitous and nontoxic commercial pigments via simple and scalable deposition techniques. It is described how, in physiological media, photovoltage and charging behavior depend on device geometry. To test cell viability and capability of neural stimulation, photostimulation of primary neurons cultured for three weeks on photocapacitor films is shown. Finally, the efficacy of the device is demonstrated by achieving direct optoelectronic stimulation of light‐insensitive retinas, proving the potential of this device platform for retinal implant technologies and for stimulation of electrogenic tissues in general. These results substantiate the conclusion that these devices are the first non‐Si optoelectronic platform capable of sufficiently large photovoltages and displacement currents to enable true capacitive stimulation of excitable cells.
Controlling Magnetic and Optical Properties of the van der Waals Crystal CrCl3−xBrx via Mixed Halide Chemistry
Authors: Abramchuk Mykola , Jaszewski Samantha , Metz Kenneth R. , Osterhoudt Gavin B. , Wang Yiping , Burch Kenneth S. , Tafti Fazel 
Published: May 2018

AbstractMagnetic van der Waals (vdW) materials are the centerpiece of atomically thin devices with spintronic and optoelectronic functions. Exploring new chemistry paths to tune their magnetic and optical properties enables significant progress in fabricating heterostructures and ultracompact devices by mechanical exfoliation. The key parameter to sustain ferromagnetism in 2D is magnetic anisotropy—a tendency of spins to align in a certain crystallographic direction known as easy‐axis. In layered materials, two limits of easy‐axis are in‐plane (XY) and out‐of‐plane (Ising). Light polarization and the helicity of topological states can couple to magnetic anisotropy with promising photoluminescence or spin‐orbitronic functions. Here, a unique experiment is designed to control the easy‐axis, the magnetic transition temperature, and the optical gap simultaneously in a series of CrCl3−xBrx crystals between CrCl3 with XY and CrBr3 with Ising anisotropy. The easy‐axis is controlled between the two limits by varying spin–orbit coupling with the Br content in CrCl3−x Brx. The optical gap, magnetic transition temperature, and interlayer spacing are all tuned linearly with x. This is the first report of controlling exchange anisotropy in a layered crystal and the first unveiling of mixed halide chemistry as a powerful technique to produce functional materials for spintronic devices.
Novel and Facile Route for the Synthesis of Tunable Boron Nitride Nanotubes Combining Atomic Layer Deposition and Annealing Processes for Water Purification
Authors: Weber Matthieu , Iatsunskyi Igor , Coy Emerson , Miele Philippe , Cornu David , Bechelany Mikhael 
Published: May 2018

AbstractThe synthesis of tunable boron nitride (BN) nanotubes is the subject of intense research because of their potential applications in various fields, from smart textile materials to emerging environmental technologies. However, the preparation of these nanomaterials remains extremely challenging. Herein, proof‐of‐concept results on the scalable synthesis of boron nitride nanotubes with tunable dimensions are reported. Combining atomic layer deposition (ALD) of boron nitride on carbon nanofibers template supports and successive annealing steps at high temperature, BN nanotubes with controllable properties are prepared. The successive annealing steps enable the crystallization of BN and the combustion of the initial carbon supports. The self‐limiting nature of the ALD process allows for the scalable coating of large scale carbon fibers matrix. High‐resolution transmission electron microscopy measurements demonstrate the exquisite dimensions control at the nanoscale and the presence of crystalline BN. The proof‐of‐concept results presented allow for independent control of the inner and external diameter dimensions, opening up unique possibilities for the precise engineering of BN nanotubes properties. The nanotubes present good mechanical properties, are easy to handle, and the assessment of their sorption properties shows that they absorb up to 110 times their own weight in oils while repelling water, which opens prospects for water purification.
Colloidal Synthesis of Mo–Ni Alloy Nanoparticles as Bifunctional Electrocatalysts for Efficient Overall Water Splitting
Authors: Zhang Taotao , Liu Xiaowang , Cui Xin , Chen Meilin , Liu Shoujie , Geng Baoyou 
Published: May 2018

AbstractThe practical use of overall water electrolysis is largely hindered by the need for precious noble metal‐based catalysts. Here, the colloidal synthesis of earth‐abundant electrocatalysts of Mo–Ni nanoparticles for efficient water splitting by thermal decomposition of Ni(acac)2 and Mo(CO)6 in the presence of 1‐octadecene and oleylamine at 320 °C is reported. It is shown that the optimized catalysts (Mo0.6Ni0.4) only require low overpotentials of 0.065 V for the hydrogen evolution reaction (HER) and of 290 mV for the oxygen evolution reaction (OER) to deliver a current density of 10 mA cm−2 in KOH (1.0 m). The as‐prepared Mo–Ni alloy nanoparticles also show extraordinary durability for both the HER and OER. A low potential of ≈1.62 V is required to yield a current density of 10 mA cm−2 when utilizing the alloy nanoparticles as bifunctional catalysts in a two‐electrode electrolyzer system. The ease of preparing either rigid or flexible high‐performance electrodes by making use of the alloy nanoparticle electrocatalysts without the need for binder further suggests the attractive application of colloidally stable nanoparticles in the field of electrochemical water splitting.
Structural Locality and Early Stage of Aggregation of Micelles in Water: An Adaptive Resolution Molecular Dynamics Study
Authors: Shadrack Jabes B. , Klein Rupert , Delle Site Luigi 
Published: May 2018

AbstractThe adaptive resolution simulation technique is employed to perform molecular dynamics simulations of a single micelle and two micelles in water. It is shown how, by identifying the essential atomistic degrees of freedom in the solvation process, the adaptive technique can be used to devise an optimal strategy for studying the aggregation of two micelles with atomistic accuracy and at a reduced computational cost. Atomistic accuracy is highly desired in such studies; in fact, if any water‐mediated effect that requires the explicit hydrogen bond network is present, then the adaptive resolution will be able to describe it. Instead, this is not possible if a generic coarse‐grained model, for example, spherical molecules without orientational bonds, is employed. In particular, the potential of mean force for the aggregation of two micelles is calculated and it is shown that the results obtained agree in a satisfactory way with the full atomistic simulation of reference. In perspective, this paper offers an example of how similar systems/problems can be efficiently treated with the adaptive resolution technique.
A New Simulation Approach for Performance Prediction of Vertically Integrated Nanogenerators
Authors: Doumit Nicole , Poulin‐Vittrant Guylaine 
Published: May 2018

AbstractThe vertically integrated nanogenerator (VING) is one of the most used designs in mechanical energy harvesting using piezoelectric nanowires, due to its easiest manufacturing process. Here, a new modeling approach is presented in order to reduce the computation time of a whole VING finite element simulation. In this work, the effect of the polymer layer (Parylene C), in which nanowires are immersed, on the electromechanical behavior of the whole VING is taken into account. The active part of the VING (nanowires–polymer composite) is considered as a 1–3 piezocomposite. It is formed with ZnO piezoelectric nanowires; however, this study can be applied to any type of piezoelectric nanowires (PZT, GaN, PVDF, etc.) and matrix materials (PDMS, PMMA, Al2O3, etc.). The present method relies on the finite element method applied to a single nanowire‐composite cell in open‐circuit condition, combined with an analytical modeling of the full VING. This approach allows the computation time to be drastically reduced without inducing significant approximation errors. The expected maximum power, internal capacitance, and optimum resistance can be deduced thanks to this efficient modeling tool, offering wide perspectives for the optimization of such VING devices.
Simultaneous Imaging of Ribonucleic Acid and Hydrogen Sulfide in Living Systems with Distinct Fluorescence Signals Using a Single Fluorescent Probe
Authors: Liu Yong , Niu Jie , Wang Weishan , Ma Yanyan , Lin Weiying 
Published: May 2018

AbstractRibonucleic acid (RNA) and hydrogen sulfide (H2S) are important genes and gaseous signal molecules in physiological environment. However, simultaneous investigation of distribution and interrelation of RNA and H2S in living systems is restricted by lack of functional molecular tools. To address this critical challenge, the development of TP‐MIVC is described as the first paradigm of the probes that can concurrently report ribonucleic acid and hydrogen sulfide with distinct fluorescence signals in the cancer cells, zebrafish, and living animals. The advantageous features of the probe include high stability, low background fluorescence, high sensitivity, and two‐photon imaging property. Significantly, regardless of normal mice or tumor mice, tumor tissues exhibit stronger fluorescence intensity than other organs. More interestingly, it is found that TP‐MIVC is capable of distinguishing normal mice and tumor mice by in vivo imaging. This study may open a new pathway for distinguishing malignant and benign tumor by fluorescence imaging of RNA.
Er3+ Sensitized 1530 nm to 1180 nm Second Near‐Infrared Window Upconversion Nanocrystals for In Vivo Biosensing
Authors: Liu Lu , Wang Shangfeng , Zhao Baozhou , Pei Peng , Fan Yong , Li Xiaomin , Zhang Fan 
Published: May 2018

AbstractFluorescent bioimaging in the second near‐infrared window (NIR‐II) can probe deep tissue with minimum auto‐fluorescence and tissue scattering. However, current NIR‐II fluorophore‐related biodetection in vivo is only focused on direct disease lesion or organ bioimaging, it is still a challenge to realize NIR‐II real‐time dynamic biosensing. A new type of Er3+ sensitized upconversion nanoparticles are presented with both excitation (1530 nm) and emission (1180 nm) located in the NIR‐II window for in vivo biosensing. The microneedle patch sensor for in vivo inflammation dynamic detection is developed based on the ratiometric fluorescence by combining the effective NIR‐II upconversion emission and H2O2 sensing organic probes under the Fenton catalysis of Fe2+. Owing to the large anti‐Stokes shifting, low auto‐fluorescence, and tissue scattering of the NIR‐II upconversion luminescence, inflammation can be dynamically evaluated in vivo at very high resolution (200×200 μm).
A Long Cycle Life, Self‐Healing Zinc–Iodine Flow Battery with High Power Density
Authors: Xie Congxin , Zhang Huamin , Xu Wenbin , Wang Wei , Li Xianfeng 
Published: May 2018

AbstractA zinc–iodine flow battery (ZIFB) with long cycle life, high energy, high power density, and self‐healing behavior is prepared. The long cycle life was achieved by employing a low‐cost porous polyolefin membrane and stable electrolytes. The pores in the membrane can be filled with a solution containing I3− that can react with zinc dendrite. Therefore, by consuming zinc dendrite, the battery can self‐recover from micro‐short‐circuiting resulting from overcharging. By using KI, ZnBr2, and KCl as electrolytes and a high ion‐conductivity porous membrane, a very high power density can be achieved. As a result, a ZIFB exhibits an energy efficiency (EE) of 82 % at 80 mA cm−2, which is 8 times higher than the currently reported ZIFBs. Furthermore, a stack with an output of 700 W was assembled and continuously run for more than 300 cycles. We believe this ZIFB can lead the way to development of new‐generation, high‐performance flow batteries.
Eosin Y as a Direct Hydrogen‐Atom Transfer Photocatalyst for the Functionalization of C−H Bonds
Authors: Fan Xuan‐Zi , Rong Jia‐Wei , Wu Hao‐Lin , Zhou Quan , Deng Hong‐Ping , Tan Jin Da , Xue Cheng‐Wen , Wu Li‐Zhu , Tao Hai‐Rong , Wu Jie 
Published: May 2018

AbstractEosin Y, a well‐known economical alternative to metal catalysts in visible‐light‐driven single‐electron transfer‐based organic transformations, can behave as an effective direct hydrogen‐atom transfer catalyst for C−H activation. Using the alkylation of C−H bonds with electron‐deficient alkenes as a model study revealed an extremely broad substrate scope, enabling easy access to a variety of important synthons. This eosin Y‐based photocatalytic hydrogen‐atom transfer strategy is promising for diverse functionalization of a wide range of native C−H bonds in a green and sustainable manner.
Formal Nickelate(−I) Complexes Supported by Group 13 Ions
Authors: Vollmer Matthew V. , Xie Jing , Cammarota Ryan C. , Young Victor G. , Bill Eckhard , Gagliardi Laura , Lu Connie C. 
Published: May 2018

AbstractFormal nickelate(−I) complexes bearing Group 13 metalloligands (M=Al and Ga) were isolated. These 17 e− complexes were synthesized by one‐electron reduction of the corresponding Ni0→MIII precursors, and were investigated by single‐crystal X‐ray diffraction, EPR spectroscopy, and quantum chemical calculations. Collectively, the experimental and computational data support: 1) the strengthening of the Ni−M bond upon one‐electron reduction, and 2) the delocalization of the unpaired spin across the Ni and M atoms. An intriguing electronic configuration is revealed where three valence electrons occupy two σ‐type bonding interactions: Ni(3d
)2→M and σ‐(Ni−M)1. The latter is an unusual Ni−M σ‐bonding molecular orbital that comprises primarily the Ni 4pz and M npz/ns atomic orbitals.
Die Interhalogenkationen [Br2F5]+ und [Br3F8]+
Authors: Ivlev Sergei I. , Karttunen Antti J. , Buchner Magnus R. , Conrad Matthias , Kraus Florian 
Published: May 2018

AbstractDie bislang einzigen Polyhalogenkationen, in denen verbrückende Fluoratome vorliegen, wurden synthetisiert und charakterisiert. Das [Br2F5]+‐Kation enthält eine symmetrische [F2Br‐μ‐F‐BrF2]‐Brücke, das [Br3F8]+‐Kation enthält unsymmetrische μ‐F‐Brücken. Die Fluoronium‐Ionen wurden in Form ihrer [SbF6]−‐Salze erhalten und Raman‐ und 19F‐NMR‐spektroskopisch sowie durch Röntgenbeugung am Einkristall untersucht. Quantenchemische Rechnungen, sowohl für die isolierten Kationen in der Gasphase als auch für die Festkörper selbst, wurden durchgeführt. Populationsanalysen ergaben, dass die μ‐F‐Atome die am stärksten negativ partialgeladenen Atome der Kationen sind.