bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease
Authors: Gluck Caroline , Qiu Chengxiang , Han Sang Youb , Palmer Matthew , Park Jihwan , Ko Yi-An , Guan Yuting , Sheng Xin , Hanson Robert L. , Huang Jing , Chen Yong , Park Ae Seo Deok , Izquierdo Maria Concepcion , Mantzaris Ioannis , Verma Amit , Pullman James , Li Hongzhe , Susztak Katalin 
Published: June 2019

AbstractEpigenetic changes might provide the biological explanation for the long-lasting impact of metabolic alterations of diabetic kidney disease development. Here we examined cytosine methylation of human kidney tubules using Illumina Infinium 450 K arrays from 91 subjects with and without diabetes and varying degrees of kidney disease using a cross-sectional design. We identify cytosine methylation changes associated with kidney structural damage and build a model for kidney function decline. We find that the methylation levels of 65 probes are associated with the degree of kidney fibrosis at genome wide significance. In total 471 probes improve the model for kidney function decline. Methylation probes associated with kidney damage and functional decline enrich on kidney regulatory regions and associate with gene expression changes, including epidermal growth factor (EGF). Altogether, our work shows that kidney methylation differences can be detected in patients with diabetic kidney disease and improve kidney function decline models indicating that they are potentially functionally important.
Phase transition in the cuprates from a magnetic-field-free stiffness meter viewpoint
Authors: Kapon Itzik , Salman Zaher , Mangel Itay , Prokscha Thomas , Gavish Nir , Keren Amit 
Published: June 2019

AbstractA method to measure the superconducting (SC) stiffness tensor $$\bar \rho _{\mathrm{s}}$$

ρ

¯

s

, without subjecting the sample to external magnetic field, is applied to La1.875Sr0.125CuO4. The method is based on the London equation $${\mathbf{J}} = - {\bar{\mathbf{\rho }}}_{\mathrm{s}}{\mathbf{A}}$$
J
=
-

ρ

¯

s

A
, where J is the current density and A is the vector potential which is applied in the SC state. Using rotor free A and measuring J via the magnetic moment of superconducting rings, $$\bar \rho _{\mathrm{s}}$$

ρ

¯

s

at T → Tc is extracted. The technique is sensitive to very small stiffnesses (penetration depths on the order of a few millimeters). The method is applied to two different rings: one with the current running only in the CuO2 planes, and another where the current must cross planes. We find different transition temperatures for the two rings, namely, there is a temperature range with two-dimensional stiffness. Additional low energy muon spin rotation measurements on the same sample determine the stiffness anisotropy at T < Tc.
Fundamental limits to quantum channel discrimination
Authors: Pirandola Stefano , Laurenza Riccardo , Lupo Cosmo , Pereira Jason L. 
Published: June 2019

AbstractWhat is the ultimate performance for discriminating two arbitrary quantum channels acting on a finite-dimensional Hilbert space? Here we address this basic question by deriving a general and fundamental lower bound. More precisely, we investigate the symmetric discrimination of two arbitrary qudit channels by means of the most general protocols based on adaptive (feedback-assisted) quantum operations. In this general scenario, we first show how port-based teleportation can be used to simplify these adaptive protocols into a much simpler non-adaptive form, designing a new type of teleportation stretching. Then, we prove that the minimum error probability affecting the channel discrimination cannot beat a bound determined by the Choi matrices of the channels, establishing a general, yet computable formula for quantum hypothesis testing. As a consequence of this bound, we derive ultimate limits and no-go theorems for adaptive quantum illumination and single-photon quantum optical resolution. Finally, we show how the methodology can also be applied to other tasks, such as quantum metrology, quantum communication and secret key generation.
Comparative transcriptome profiling of multi-ovary wheat under heterogeneous cytoplasm suppression
Authors: Guo Jialin , Zhang Gaisheng , Song Yulong , Ma Shoucai , Niu Na , Wang Junwei 
Published: June 2019

AbstractDUOII is a multi-ovary wheat line with two or three pistils and three stamens in each floret. The multi-ovary trait of DUOII is controlled by a dominant gene, whose expression can be suppressed by the heterogeneous cytoplasm of TeZhiI (TZI), a line with the nucleus of common wheat and the cytoplasm of Aegilops. DUOII (♀) × TZI (♂) shows multi-ovary trait, while TZI (♀) × DUOII (♂) shows mono-ovary. Observing the developmental process, we found that the critical stage of additional pistil primordium development was when the young spikes were 2–6 mm long. To elucidate the molecular mechanisms that are responsible for the heterogeneous cytoplasmic suppression of the multi-ovary gene, we RNA-sequenced the entire transcriptome of 2–6 mm long young spikes obtained from the reciprocal crosses between DUOII and TZI. A total of 600 differentially expressed genes (DEGs) was identified. Functional annotation of these DEGs showed that the heterogeneous cytoplasmic suppression of additional pistil development mainly involved four pathways, i.e., chloroplast metabolism, DNA replication and repair, hormone signal transduction, and trehalose-6-phosphate in the primordium development stage, which cooperated to modulate the multi-ovary gene expression under heterogeneous cytoplasmic suppression.
Adjuvant chemotherapy versus observation after radical cystectomy in patients with node-positive bladder cancer
Authors: Pak Sahyun , You Dalsan , Jeong In Gab , Song Cheryn , Lee Jae-Lyun , Hong Bumsik , Hong Jun Hyuk , Kim Choung-Soo , Ahn Hanjong 
Published: June 2019

AbstractThis retrospective study compared adjuvant chemotherapy (AC) versus observation after radical cystectomy (RC) in patients with node-positive bladder cancer (pN+). Outcomes were reviewed in patients with pTanyN1-3M0 bladder cancer who underwent RC with or without AC between 1995 and 2017. Baseline characteristics between the two groups were controlled with inverse probability of treatment weighting (IPTW)-adjusted analyses. Of 281 enrolled patients, the 3-year IPTW-adjusted rates of overall survival was higher in the AC group than the RC group (46.4% vs. 33.7%, p = 0.024). AC was an independent predictor of overall survival (hazard ratio = 0.48; P < 0.0001). When patients were subdivided by lymph node density (LND), the 3-year overall survival rates were similar between the AC and RC groups in patients with LND < 9%, but higher in the AC group in patients with LND 9–25% (53.4% vs. 23.7%) and LND ≥ 25% (27.4% vs. 16.1%). The numbers needed to treat to prevent one death at 3 years were three and nine in patients with LND 9–25% and ≥25%, respectively. In conclusion, AC after RC was associated with improved overall survival in patients with node-positive bladder cancer. Patients with an intermediate nodal burden may benefit most from AC.
Pre-Operative Delta-MELD is an Independent Predictor of Higher Mortality following Liver Transplantation
Authors: Cholankeril George , Li Andrew A. , Dennis Brittany B. , Gadiparthi Chiranjeevi , Kim Donghee , Toll Alice E. , Maliakkal Benedict J. , Satapathy Sanjaya K. , Nair Satheesh , Ahmed Aijaz 
Published: June 2019

AbstractClinical decompensation immediately prior to liver transplantation may affect post-liver transplant (LT) outcomes. Using the serial Model for End-Stage Liver Disease (MELD) scores recorded in the United Network for Organ Sharing national registry (2010–2017), we analyzed post-LT mortality among adult LT recipients based on the degree of fluctuation in MELD score during the 30-day period prior to LT surgery. Delta-MELD (D-MELD) was defined as recipient MELD score at LT minus lowest MELD score within the preceding 30 days. Impact of D-MELD as a continuous and categorical variable (D-MELD 0–4, 5–10, >10) on early, 30-day post-LT mortality was assessed. Overall, a total of 12,785 LT recipients were analyzed, of which 8,862 (67.9%) had a pre-operative D-MELD 0–4; 2,574 (20.1%) with a D-MELD 5–10; and 1,529 (12.0%) with a D-MELD > 10. One-point incremental increase in pre-operative D-MELD (adjusted HR, 1.07, 95% CI: 1.04–1.10) was associated with higher 30-day post-LT mortality. Moreover, pre-operative D-MELD > 10 was associated with nearly a two-fold increased risk for 30-day post-LT mortality (adjusted HR, 1.89, 95% CI: 1.30–2.77) compared to D-MELD 0–4. The increased risk of pre-LT mortality associated with severity of clinical decompensation assessed by the magnitude of pre-operative D-MELD persists in the early post-LT period.
Role of the S1P pathway and inhibition by fingolimod in preventing hemorrhagic transformation after stroke
Authors: Salas-Perdomo Angélica , Miró-Mur Francesc , Gallizioli Mattia , Brait Vanessa H. , Justicia Carles , Meissner Anja , Urra Xabier , Chamorro Angel , Planas Anna M. 
Published: June 2019

AbstractHemorrhagic transformation (HT) is a complication of severe ischemic stroke after revascularization. Patients with low platelet counts do not receive reperfusion therapies due to high risk of HT. The immunomodulatory drug fingolimod attenuated HT after tissue plasminogen activator in a thromboembolic stroke model, but the underlying mechanism is unknown. Fingolimod acts on several sphingosine-1-phosphate (S1P) receptors, prevents lymphocyte trafficking to inflamed tissues, and affects brain and vascular cells. This study aimed to investigate changes in S1P-signaling in response to brain ischemia/reperfusion and the effects of the S1P receptor modulator fingolimod on HT. We studied brain expression of S1P signaling components, S1P concentration, and immune cell infiltration after ischemia/reperfusion in mice. We administered fingolimod after ischemia to wild-type mice, lymphocyte-deficient Rag2−/− mice, and mice with low platelet counts. Ischemia increased S1P-generating enzyme SphK1 mRNA, S1P concentration, and S1P receptor-1 (S1P1)+ T-cells in the brain. Fingolimod prevented lymphocyte infiltration, and attenuated the severity of HT in Rag2−/− mice but it was ineffective under thrombocytopenia. Fingolimod prevented β-catenin degradation but not Evans blue extravasation. Ischemia/reperfusion upregulates brain S1P signaling pathway, and fingolimod exerts local effects that attenuate HT. Although fingolimod seems to act on the brain tissue, it did not prevent blood-brain barrier leakage.
A PDM-based bi-directional fibre-FSO integration with two RSOAs scheme
Authors: Tsai Wen-Shing , Lu Hai-Han , Huang Yong-Cheng , Tu Shi-Cheng , Huang Qi-Ping 
Published: June 2019

AbstractA polarization-division-multiplexing (PDM)-based bi-directional fibre-free-space optical (FSO) integration with two reflective semiconductor optical amplifiers (RSOAs) scheme to efficiently wipe off the modulated data for upstream modulation is proposed and successfully demonstrated. For downstream modulation, a high-speed 128 Gb/s vestigial sideband (VSB)-four-level pulse amplitude modulation (PAM4) fibre-FSO integration is feasibly established. The transmission capacity is increased up to four times through PDM operation and VSB-PAM4 modulation. For uplink transmission, a 10 Gb/s non-return-to-zero fibre-FSO integration with two RSOAs scheme to effectually erase the downstream modulated data is practically constructed. The upstream performance exhibits noticeable enhancement by using of two RSOAs scheme to wipe off the modulated data clearly. Such illustrated PDM-based bi-directional 128 Gb/s (downstream)/10 Gb/s (upstream) fibre-FSO integration is shown to be prominent not only due to its enhancement in the convergence of fibre backhaul and optical wireless reach extender but also because of its benefit in bi-directional transmission for affording high transmission capacity with long-reach optical wireless link and improved upstream performance.
The Role of Prekindergarten Spanish in Predicting First-Grade English Word Reading Among Dual-Language Learners
Authors:   Language and Reading Research Consortium (LARRC), Mesa Carol , Yeomans-Maldonado Gloria 
Published: June 2019

Purpose
The purpose of the current study was to examine the role that the 1st language, Spanish, at prekindergarten (pre-K) plays in predicting 2nd language (L2), English, word reading in 1st grade. In addition, it examines the role of conceptual vocabulary in predicting word reading in English.

Method
As part of a longitudinal study of predictors and models of reading comprehension from pre-K to 3rd grade, 248 children attending preschool programs completed Spanish and English measures in the spring of each academic year. In this article, we report the results of English and Spanish measures of oral language and literacy skills that were administered in pre-K and 4 measures of English word reading that were administered in 1st grade.

Results
Results from structural equation modeling indicated that Spanish oral language made significant direct and indirect contributions to English oral language and word reading. Further, results supported previous evidence indicating that L2 letter knowledge and L2 oral language proficiency are the strongest predictors of L2 word reading in 1st grade.

Discussion
Similar to findings with monolingual English-speaking children, results support findings that, in the early stages of reading development, oral language in both 1st language and L2 make a significant and independent contribution to word reading. This study has important implications for the support of oral language skills in Latino preschool children.
Analysis of putative exoplanetary signatures found in light curves of two sdBV stars observed by Kepler
Authors: Blokesz A. , Krzesinski J. , Kedziora-Chudczer L. 
Published: June 2019

Context. We investigate the validity of the claim that invokes two extreme exoplanetary system candidates around the pulsating B-type subdwarfs KIC 10001893 and KIC 5807616 from the primary Kepler field.
Aims. Our goal was to find characteristics and the source of weak signals that are observed in these subdwarf light curves.
Methods. To achieve this, we analyzed short- and long-cadence Kepler data of the two stars by means of a Fourier transform and compared the results to Fourier transforms of simulated light curves to which we added exoplanetary signals. The long-cadence data of KIC 10001893 were extracted from CCD images of a nearby star, KIC 10001898, using a point spread function reduction technique.
Results. It appears that the amplitudes of the Fourier transform signals that were found in the low-frequency region depend on the methods that are used to extract and prepare Kepler data. We demonstrate that using a comparison star for space telescope data can significantly reduce artifacts. Our simulations also show that a weak signal of constant amplitude and frequency, added to a stellar light curve, conserves its frequency in Fourier transform amplitude spectra to within 0.03 μHz.
Conclusions. Based on our simulations, we conclude that the two low-frequency Fourier transform signals found in KIC 5807616 are likely the combined frequencies of the lower amplitude pulsating modes of the star. In the case of KIC 10001893, the signal amplitudes that are visible in the light curve depend on the data set and reduction methods. The strongest signal decreases significantly in amplitude when KIC 10001898 is used as a comparison star. Finally, we recommend that the signal detection threshold is increased to 5σ (or higher) for a Fourier transform analysis of Kepler data in low-frequency regions.
The TeV-emitting radio galaxy 3C 264
Authors: Boccardi B. , Migliori G. , Grandi P. , Torresi E. , Mertens F. , Karamanavis V. , Angioni R. , Vignali C. 
Published: June 2019

Context.In March 2018, the detection by VERITAS of very-high-energy emission (VHE >  100 GeV) from 3C 264 was reported. This is the sixth, and second most distant, radio galaxy ever detected in the TeV regime.Aims.In this article we present a radio and X-ray analysis of the jet in 3C 264. We determine the main physical parameters of the parsec-scale flow and explore the implications of the inferred kinematic structure for radiative models of thisγ-ray emitting jet.Methods.The radio data set is comprised of VLBI observations at 15 GHz from the MOJAVE program, and covers a time period of about two years. Through a segmented wavelet decomposition method (WISE code), we estimated the apparent displacement of individual plasma features; we then performed a pixel-based analysis of the stacked image to determine the jet shape. The X-ray data set includes all available observations from theChandra, XMM, andSwiftsatellites, and is used, together with archival data in the other bands, to build the spectral energy distribution (SED).Results.Proper motion is mostly detected along the edges of the flow, which appears strongly limb brightened. The apparent speeds increase as a function of distance from the core up to a maximum of ∼11.5 c. This constrains the jet viewing angle to assume relatively small values (θ ≲ 10°). In the acceleration region, extending up to a de-projected distance of ∼4.8 × 104Schwarzschild radii (∼11 pc), the jet is collimating (r ∝ z0.40 ± 0.04), as predicted for a magnetically-driven plasma flow. By assuming that the core region is indeed magnetically dominated (UB/Ue >  1), the SED and the jet power can be well reproduced in the framework of leptonic models, provided that the high-energy component is associated to a second emitting region. The possibility that this region is located at the end of the acceleration zone, either in the jet layer or in the spine, is explored in the modeling.
Integrals of motion for non-axisymmetric potentials
Authors: Bienaymé O. 
Published: June 2019

Context. The modelling of stationary galactic stellar populations can be performed using distribution functions.
Aims. This paper aims to write explicit integrals of motion and distribution functions.
Methods. We propose an analytic formulation of the integrals of motion with an explicit dependence on potential. This formulation applies to potentials with rotational symmetry or triaxial symmetry. It is exact for Stäckel potentials and approximate for other potentials.
Results. Modelling a stationary stellar population using these integrals of motion allows the force field to be found with satisfactory accuracy. On the other hand, the mass density distribution that generates the force field and the gravitational potential is recovered with less accuracy due to lower precision in modelling box-type orbits.
Early metabolic response assessment of breast cancer liver
metastases: 4-week posttreatment FDG PET predicts survival after 90Y
microsphere radioembolization
Authors: Sabet Amir , Ries Martin , Al-Khalaf Yamen , Meyer Carsten , Rudlowski Christian , Simon Birgit , Khreish Fadi , Ezziddin Samer 
Published: June 2019

Abstract
Aim To evaluate the feasibility of early metabolic response assessment
with 18F-FDG PET/CT in patients with breast cancer liver metastases 4
weeks after radioembolization with Yttrium-90 labeled microspheres.
Methods 25 patients (mean age 58y, range 40–74) with advanced stage liver
metastases of breast cancer were treated with 1.9 ± 0.4 GBq of 90Y-microspheres
in the salvage setting and underwent 18F-FDG PET/CT at baseline and 4
weeks post-radioembolization. 14 patients (56 %) had an excessive hepatic tumor
burden (> 50 % of total liver volume), 21 patients (84 %) had extrahepatic
disease. Liver lesions with the highest SUVmax were selected as
target lesions and a cut-off was set at 50 % reduction to separate responders
from non-responders. The predictive impact of metabolic response on overall
survival (OS) was investigated along with other prognostic factors.
Results The median OS in this highly advanced metastatic cohort was 7
months (95 % CI, 5–9). All patients had a reduction in SUVmax (mean
ΔSUVmax: –49 ± 26 %) at 4 weeks post-treatment. Patients with
> 50 % SUVmax reduction survived longer (median OS 13 mo, 95 % CI
8–18) than the remaining patients (median OS 4 mo, 95 % CI 2–6; p = 0.001). From
all investigated baseline factors including age, performance status, and
presence of extra-hepatic disease, only the hepatic tumor burden had a
significant impact on OS (p = 0.02).
Conclusions This is the first preliminary evidence in breast cancer that
early post-radioembolization molecular response assessment of treated liver
metastases – as early as 4 weeks posttreatment – may predict survival. If
confirmed by larger series, FDG PET/CT could be considered for early
response-adapted treatment modifications.
Tablet-basiertes Trainingsmodell zum Verständnis des
Zusammenwirkens von extrinsischer Unterarmmuskulatur und intrinsischer
Handmuskulatur
Authors: Andreou Andreas , Ganser Joachim 
Published: June 2019

ZusammenfassungDas Zusammenwirken verschiedener Muskeln in der Ausführung spezieller Handgriffe
ist komplizierter als gedacht. Wir haben deshalb ein Tablet-basiertes
Trainingsmodell entworfen, um zur selbständigen Komposition spezifischer
Handgriffe unter gewichtetem Einsatz der zur Verfügung stehenden Instrumente,
d. h. der extrinsischen und intrinsischen Unterarm- und Handmuskeln zu
animieren. Unsere Lösungen für die gestellten Aufgaben erheben keinen Anspruch
auf Richtigkeit, da es eine entsprechende validierte Datenbank noch nicht gibt.
Wir möchten mit dem Modell lediglich zur Weiterbildung und zum Spaß in der
täglichen Arbeit beitragen.
Edgeworthia papyrifera Regulates Osteoblast and Osteoclast Differentiation In Vitro and Exhibits Anti-osteoporosis Activity in Animal Models of Osteoporosis
Authors: Kim Pansoo , Nam Yeon-Ju , Kim Woo Jung , Kim Jin Kyu , Lee Gyeongbeen , Song Myung-Jin , Yang Jungeun , Yi Sun Shin , Lee Jong Suk , Seo Jin-Ho , Choi Yongmun 
Published: June 2019

AbstractOsteoporosis is a clinical condition characterized by low bone strength that leads to an increased risk of fracture. Strategies for the treatment of osteoporosis involve inhibition of bone resorption by osteoclasts and an increase of bone formation by osteoblasts. Here, we identified the extract derived from the stem part of Edgeworthia papyrifera that enhanced differentiation of MC3T3-E1 cells to osteoblast-like cells and inhibited osteoclast differentiation of RAW 264.7 cells in vitro. In support of our observation, rutin and daphnoretin, which were previously reported to inhibit osteoclast differentiation, were identified in E. papyrifera extract. In an animal model of osteoporosis, the ovariectomy-induced increases in bone resorption biomarkers such as pyridinoline and tartrate-resistant acid phosphatase were significantly reduced by E. papyrifera extract administration at 25.6 and 48.1%, respectively. Furthermore, the ovariectomy-induced bone loss in animal models of osteoporosis was significantly prevented by the administration of E. papyrifera in our study. Taking these observations into account, we suggest that E. papyrifera is an interesting candidate for further exploration as an anti-osteoporotic agent.
Development of a Hydrazine-Catalyzed Carbonyl-Olefin Metathesis Reaction
Authors: Lambert Tristan H. 
Published: June 2019

Carbonyl-olefin metathesis is a potentially powerful yet underexplored reaction in organic synthesis. In recent years, however, this situation has begun to change, most notably with the introduction of several different catalytic technologies. The development of one of those new strategies, based on hydrazine catalysts and a novel [3+2] paradigm for double bond metathesis, is discussed herein. First, the stage is set with a description of some potential applications of carbonyl-olefin metathesis and a discussion of alternative strategies for this intriguing reaction.1	Introduction2	Potential Applications of Carbonyl-Olefin Metathesis3	Carbonyl-Olefin Metathesis Strategies4	Direct (Type I): Non-Catalytic5	Direct (Type I): Acid-Catalyzed6	Indirect (Type II): Metal Alkylidenes7	Indirect (Type III): Hydrazine-Catalyzed8	Conclusion