bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triggered codeswitching: Lexical processing and conversational dynamics
Authors: Broersma Mirjam , Carter Diana , Donnelly Kevin , Konopka Agnieszka 
Published: March 2019

AbstractThis study investigates the psycholinguistic process underlying triggered codeswitching – codeswitching facilitated by the occurrence of cognates – within the context of conversational dynamics. It confirms that, in natural bilingual speech, lexical selection of cognates can facilitate codeswitching by enhancing the activation of the non-selected language. Analyses of a large-scale corpus of Welsh–English conversational speech showed that 1) producing cognates facilitated codeswitching, 2) speakers who generally produced more cognates generally codeswitched more, even in clauses that did not contain cognates, 3) larger numbers of cognates in a clause increased the likelihood of codeswitching, 4) codeswitching temporarily remained facilitated after the production of cognates, and 5) hearing rather than producing cognates did not facilitate codeswitching. The findings confirm the validity of the proposed cognitive account of triggered codeswitching, and clarify the relation between the lexical activation of cognates and consecutive language choice, in accord with current insights in lexical processing.
Attitudes towards Lesbian, Gay, Bisexual and Transgender Old Age Scale (EAFV– LGBT): Elaboration and Psychometric Evidence
Authors: Diógenes de Medeiros Emerson , Fernandes de Araújo Ludgleydson , Victor de Oliveira Santos José , Souza Thais Coutinho , Monteiro Renan Pereira 
Published: March 2019

AbstractThe aim of this study was to construct and validate an Attitude Scale relating to Lesbian, Gay, Bisexual and Transgender (LGBT) old age (EAFV-LGBT). The first study, consisting of 29 items in its preliminary version, counted on 266 individuals from the public in general with an average age of 28.6 years (DP = 9.70), exploratory factor analysis was undertaken and EAFV-LGBT consisted of twelve items, with eigenvalues of 5.08, accounting for 43.8% of total variance. The second study consisted of 261 individuals from the general public with an average age of 23.18 years (DP = 8.25), confirmatory factor analysis was undertaken and psychometric parameters by means of Item Response Theory and conformation of the EAFV-LGBT structure. After this analysis, two items were excluded due to lower psychometric values, in which the 10 item scale proved to be valid and precise in evaluating individuals with varying levels of the latent trait. An adequate fit of the model to the data was verified, CFI = 0.97; TLI = 0.6; RMSEA, 90% CI = 0.05 [0.01, 0.07]. Lastly, the EAFV-LGBT has valid psychometric properties to evaluate attitudes towards LGBT old age.
Frequent interactions of Tibet's CO2 emissions with those of other regions in China
Authors: Ou Jiamin , Meng Jing , Zheng Heran , Mi Zhifu , Shan Yuli , Guan Dabo 
Published: March 2019

AbstractTibet is usually missing from China's emission accounts, especially from those of consumption‐based emissions. In this study, we developed a multiregional input‐output table for 31 provinces in China and examined the production‐ and consumption‐based characteristics of Tibet's CO2 emissions in 2012. Results show that the consumption‐based CO2 emissions in Tibet (18.8 Mt, similar to Guinea's emissions in 2015) were three times as high as the production‐based estimate (6.2 Mt). Tibet displays unique emission patterns with the highest ratio of consumption‐ to production‐based emissions in China, which are more similar with the east developed provinces rather than its counterparts in west China. More than half of Tibet's consumption‐based emissions are supported by Qinghai, Hebei, Sichuan, and others, enabled by the Qinghai‐Tibet railway that connected Tibet to China's national railway system. High carbon footprint but low life expectancy is found in Tibet, suggesting the emerging need of a more sustainable consumption pathway under the intensifying interregional connections by Belt and Road Initiative.
Radiative Forcing by Dust and Black Carbon on the Juneau Icefield, Alaska
Authors: Nagorski Sonia A. , Kaspari Susan D. , Hood Eran , Fellman Jason B. , Skiles S. McKenzie 
Published: March 2019

AbstractHere we present the first known data set on black carbon (BC) and mineral dust concentrations in snow from the Juneau Icefield (JIF) in southeastern Alaska, where glacier melt rates are among the highest on Earth. In May 2016, concentrations of BC (0.4–3.1 μg/L) and dust (0.2–34 mg/L) were relatively low and decreased toward the interior of the JIF. The associated radiative forcing (RF) averaged 4 W/m2. In July, after 10 weeks of exposure, the aged snow surface had substantially higher concentrations of BC (2.1–14.8 μg/L) and dust (11–72 mg/L) that were not spatially distributed by elevation or distance from the coast. RF by dust and BC ranged from 70 to 130 W/m2 (87 W/m2 average) across the JIF in July, and RF was dominated by dust. The associated median snow water equivalent reduction in the July samples is estimated at 10–18 mm/day, potentially advancing melt on the scale of days to weeks. Aging of the snow surface in summer likely resulted in a positive feedback of melt consolidation, enhanced solar absorption and melting, and further concentration of surface particles. Regional projections of warming temperatures and increased rain at the expense of snow make it likely that summer season darkening will become a more important contributor to the high melt rates on the JIF. Further studies are needed to elucidate the spatiotemporal occurrence of various light‐absorbing particles on the JIF, and models of ice field wastage should incorporate their associated RF.
High‐Temperature Extreme Events Over Africa Under 1.5 and 2 °C of Global Warming
Authors: Nangombe Shingirai S. , Zhou Tianjun , Zhang Wenxia , Zou Liwei , Li Donghuan 
Published: March 2019

AbstractWith anthropogenic global warming, heat‐related extreme events are projected to increase in severity and frequency. Already vulnerable regions like Africa will be hard‐hit. Therefore, such regions could benefit from low global warming levels. Using the Community Earth System Model low warming simulations, we investigate changes in temperature extremes across Africa as a function of global mean temperature in the context of the implications of the Paris Agreement's targets. A significant warming across Africa is projected at the 1.5 °C warming world and is amplified at the 2 °C world, exceeding the mean global warming rate. Specifically, North Africa and East Africa regions are projected to have the highest and lowest temperature changes of 0.63 °C (0.60–0.67 °C) and 0.50 °C (0.47–0.54 °C), respectively, between the 1.5 and 2 °C warmer worlds. Consequently, hot events are also estimated to increase with global warming. We showed that limiting warming to 1.5 °C instead of 2 °C may lead to 29% (27–31%) to 35% (33–37%) reduction in severity of hot events and to 31% (30–33%) to 42% (39–48%) reduction in the frequency of the threshold‐based high‐temperature events across Africa. The highest reductions are projected over North Africa. Furthermore, restricting warming to 0.5 °C lower than 2 °C might also result in 28% (34–40%) to 37% (25–34%) reduction in severity of once‐in‐10/20‐year heat events across Africa with North Africa having the highest benefits than tropical regions. Thus, restricting warming to low levels may indeed translate to substantial benefits of reduced intensity and frequency of extreme heat events across Africa.
The Influence of Weather Systems in Controlling Mass Balance in the Southern Alps of New Zealand
Authors: Cullen Nicolas J. , Gibson Peter B. , Mölg Thomas , Conway Jonathan P. , Sirguey Pascal , Kingston Daniel G. 
Published: March 2019

AbstractThe recent advance of some fast‐responding glaciers in New Zealand demonstrates that regional variability in atmospheric circulation can counteract the effects of global warming. Until recently, a key challenge in quantifying how weather systems influence glaciers has been the lack of observational data from high‐elevation sites in the Southern Alps. Using high‐quality meteorological and glaciological observations from Brewster Glacier over four summers and two winters, a physically based mass balance model is used to resolve daily ablation and solid precipitation. Composite analysis confirms ablation is largely controlled by changes in meridional airflow, with high ablation associated with north to northwest airflow, while low ablation is associated with south to southwest airflow. The largest snowfall events in the cool season also occur during northwesterly airflow, highlighting the importance of seasonality (i.e., whether an event occurs in the ablation or accumulation period) for mass balance. Application of a synoptic weather typing approach commonly used for the New Zealand region, known broadly as Kidson weather types, revealed that three established regimes (trough, zonal, and blocking) are less effective in resolving variability in ablation and snowfall than a simple procedure that groups weather types using geostrophic flow direction. The frequency of four weather types can explain approximately 40% of the variance in mass balance over a 42‐year period. This highlights that future regional variability or trends in large‐scale circulation and their seasonality, superimposed on background warming, will be important in shaping glacier mass balance in the coming decades.
Phase I trial of isatuximab monotherapy in the treatment of refractory multiple myeloma
Authors: Martin Thomas , Strickland Stephen , Glenn Martha , Charpentier Eric , Guillemin Hélène , Hsu Karl , Mikhael Joseph 
Published: March 2019

AbstractThis phase I dose-escalation/expansion study evaluated isatuximab (anti-CD38 monoclonal antibody) monotherapy in patients with relapsed/refractory multiple myeloma (RRMM). Patients progressing on or after standard therapy received intravenous isatuximab (weekly [QW] or every 2 weeks [Q2W]). The primary objective was to determine the maximum tolerated dose (MTD) of isatuximab. Overall, 84 patients received ≥ 1 dose of isatuximab. The MTD was not reached; no cumulative adverse reactions were noted. The most frequent adverse events were infusion reactions (IRs), occurring in 37/73 patients (51%) following introduction of mandatory prophylaxis. IRs were mostly grade 1/2, occurred predominantly during Cycle 1, and led to treatment discontinuation in two patients. CD38 receptor occupancy reached a plateau of 80% with isatuximab 20 mg/kg (highest dose tested) and was associated with clinical response. In patients receiving isatuximab ≥ 10 mg/kg, overall response rate (ORR) was 23.8% (15/63), including one complete response. In high-risk patients treated with isatuximab 10 mg/kg (QW or Q2W), ORR was 16.7% (3/18). Median (range) duration of response at doses ≥ 10 mg/kg was 25 (8–30) weeks among high-risk patients versus 36 (6–85) weeks for other patients. In conclusion, isatuximab demonstrated a manageable safety profile and clinical activity in patients with RRMM.
Spontaneous formation and relaxation of spin domains in antiferromagnetic spin-1 condensates
Authors: Jiménez-García K. , Invernizzi A. , Evrard B. , Frapolli C. , Dalibard J. , Gerbier F. 
Published: March 2019

AbstractMany-body systems at low temperatures generally organize themselves into ordered phases, whose nature and symmetries are captured by an order parameter. This order parameter is spatially uniform in the simplest cases, for example the macroscopic magnetization of a ferromagnetic material. Non-uniform situations also exist in nature, for instance in antiferromagnetic materials, where the magnetization alternates in space, or in the so-called stripe phases emerging for itinerant electrons in strongly correlated materials. Understanding such inhomogeneously ordered states is of central importance in many-body physics. Here we study experimentally the magnetic ordering of itinerant spin-1 bosons in inhomegeneous spin domains at nano-Kelvin temperatures. We demonstrate that spin domains form spontaneously, that is purely because of the antiferromagnetic interactions between the atoms and in the absence of external magnetic forces, after a phase separation transition. Furthermore, we explore how the equilibrium domain configuration emerges from an initial state prepared far from equilibrium.
Specialized dendritic cells induce tumor-promoting IL-10+IL-17+ FoxP3neg regulatory CD4+ T cells in pancreatic carcinoma
Authors: Barilla Rocky M. , Diskin Brian , Caso Raul Caso , Lee Ki Buom , Mohan Navyatha , Buttar Chandan , Adam Salma , Sekendiz Zennur , Wang Junjie , Salas Ruben D. , Cassini Marcelo F. , Karlen Jason , Sundberg Belen , Akbar Hashem , Levchenko Dmitry , Gakhal Inderdeep , Gutierrez Johana , Wang Wei , Hundeyin Mautin , Torres-Hernandez Alejandro , Leinwand Joshua , Kurz Emma , Rossi Juan A. Kochen , Mishra Ankita , Liria Miguel , Sanchez Gustavo , Panta Jyoti , Loke P’ng , Aykut Berk , Miller George 
Published: March 2019

AbstractThe drivers and the specification of CD4+ T cell differentiation in the tumor microenvironment and their contributions to tumor immunity or tolerance are incompletely understood. Using models of pancreatic ductal adenocarcinoma (PDA), we show that a distinct subset of tumor-infiltrating dendritic cells (DC) promotes PDA growth by directing a unique TH-program. Specifically, CD11b+CD103− DC predominate in PDA, express high IL-23 and TGF-β, and induce FoxP3neg tumor-promoting IL-10+IL-17+IFNγ+ regulatory CD4+ T cells. The balance between this distinctive TH program and canonical FoxP3+ TREGS is unaffected by pattern recognition receptor ligation and is modulated by DC expression of retinoic acid. This TH-signature is mimicked in human PDA where it is associated with immune-tolerance and diminished patient survival. Our data suggest that CD11b+CD103− DC promote CD4+ T cell tolerance in PDA which may underscore its resistance to immunotherapy.
Enhanced Dopamine in Prodromal Schizophrenia (EDiPS): a new animal model of relevance to schizophrenia
Authors: Petty Alice , Cui Xiaoying , Tesiram Yasvir , Kirik Deniz , Howes Oliver , Eyles Darryl 
Published: March 2019

AbstractOne of the most robust neurochemical abnormalities reported in patients living with schizophrenia is an increase in dopamine (DA) synthesis and release in the dorsal striatum (DS). Importantly, it appears that this increase progresses as a patient transitions from a prodromal stage to the clinical diagnosis of schizophrenia. Here we have recreated this pathophysiology in an animal model by increasing the capacity for DA synthesis preferentially within the DS. To achieve this we administer a genetic construct containing the rate-limiting enzymes in DA synthesis—tyrosine hydroxylase (TH), and GTP cyclohydrolase 1 (GCH1) (packaged within an adeno-associated virus)—into the substantia nigra pars compacta (SNpc) of adolescent animals. We refer to this model as “Enhanced Dopamine in Prodromal Schizophrenia” (EDiPS). We first confirmed that the TH enzyme is preferentially increased in the DS. As adults, EDiPS animals release significantly more DA in the DS following a low dose of amphetamine (AMPH), have increased AMPH-induced hyperlocomotion and show deficits in pre-pulse inhibition (PPI). The glutamatergic response to AMPH is also altered, again in the DS. EDiPS represents an ideal experimental platform to (a) understand how a preferential increase in DA synthesis capacity in the DS relates to “positive” symptoms in schizophrenia; (b) understand how manipulation of DS DA may influence other neurotransmitter systems shown to be altered in patients with schizophrenia; (c) allow researchers to follow an “at risk”-like disease course from adolescence to adulthood; and (d) ultimately allow trials of putative prophylactic agents to prevent disease onset in vulnerable populations.
The First Definite Lambeosaurine Bone From the Liscomb Bonebed of the Upper Cretaceous Prince Creek Formation, Alaska, United States
Authors: Takasaki Ryuji , Fiorillo Anthony R. , Kobayashi Yoshitsugu , Tykoski Ronald S. , McCarthy Paul J. 
Published: March 2019

AbstractThe Prince Creek Formation of Alaska, a rock unit that represents lower coastal plain and delta deposits, is one of the most important formations in the world for understanding vertebrate ecology in the Arctic during the Cretaceous. Here we report on an isolated cranial material, supraoccipital, of a lambeosaurine hadrosaurid from the Liscomb Bonebed of the Prince Creek Formation. The lambeosaurine supraoccipital has well-developed squamosal bosses and a short sutural surface with the exoccipital-opisthotic complex, and is similar to lambeosaurine supraoccipitals from the Dinosaur Park Formation in having anteriorly positioned squamosal bosses. Affinities with Canadian lambeosaurines elucidate more extensive faunal exchange between the Arctic and lower paleolatitudes which was previously suggested by the presence of Edmontosaurus, Pachyrhinosaurus, tyrannosaurids, and troodontids in both regions. The presence of one lambeosaurine and nine hadrosaurine supraoccipitals in the Liscomb Bonebed suggests hadrosaurine dominated faunal structure as in the Careless Creek Quarry of the USA that was also deposited under a near-shore environment. It differs from the lambeosaurine dominant structures of localities in Russia and China interpreted as inland environments. This may suggest that lambeosaurines had less preference for near-shore environments than hadrosaurines in both Arctic and lower paleolatitudes.
Monocytes/Macrophages play a pathogenic role in IL-23 mediated psoriasis-like skin inflammation
Authors: Wang Yibing , Edelmayer Rebecca , Wetter Joe , Salte Katherine , Gauvin Donna , Leys Laura , Paulsboe Stephanie , Su Zhi , Weinberg Isaac , Namovic Marian , Gauld Stephen B. , Honore Prisca , Scott Victoria E. , McGaraughty Steve 
Published: March 2019

AbstractPsoriasis is an immune-mediated inflammatory skin disease that affects millions worldwide. Studying immune cells involved in psoriasis pathogenesis is essential to identify effective and safe therapeutics for the disease. Using human psoriasis skin, activated macrophages were observed in both lesional and non-lesional skin, but were elevated in lesional skin. Activation of the IL-23/IL-17 pathway is integral to the development of psoriasis. To further characterize the monocyte/macrophage (Mon/Mac) population when the IL-23 pathway is activated, a murine model of intradermal injection of IL-23 was used. Flow cytometry revealed that Mon/Mac cells were the dominant immune population, particularly late in the model, highlighted by strong presence of Ly6ChiMHC IIhi cells. The Mon/Mac cells were also shown to have high expression for TNFα but not IL-17A. Prophylactic dosing of a CSF-1R inhibitor to deplete Mon/Mac cells significantly reduced several inflammatory mediators from the skin tissue suggesting a pathogenic role for Mon/Mac. Treatment dosing of the inhibitor produced a less robust effect. Mon/Mac cells were also differentiated by levels of Ki67 and TNFα expression. These data point to an important contribution of Mon/Mac cells in IL-23 related skin inflammation and suggest that these cells are a significant player in the underlying pathophysiology of psoriasis.
Increase of genetic diversity indicates ecological opportunities in recurrent-fire landscapes for wall lizards
Authors: Ferreira Diana , Pinho Catarina , Brito José Carlos , Santos Xavier 
Published: March 2019

AbstractSocioeconomic and climatic factors are modifying fire regimes with an increase of fire frequency and extension. Unfortunately, the effects of recurrent fires on biological processes that ultimately affect the genetic diversity of animal populations are mostly unknown. We examined genetic patterns of diversity in the wall lizardPodarcis guadarramaein northern Portugal, one of the European regions with the highest percentage of burnt land. This species is a small saxicolous lizard as it inhabits natural outcrops and artificial stone walls, likely in recurrent-fire landscapes. We genotyped nine microsatellites from ten populations selected according to a gradient in fire recurrence, and compared genetic diversity indexes and demographic patterns among them. At the population level, we hypothesize that a high level of mortality and population bottlenecks are expected to reduce genetic heterozygosity in sampled localities affected by recurrent fires. Alternatively, genetic signatures are expected to be absent whether fire did not cause high mortality. Regardless of levels of mortality, we expect a gain in genetic diversity whether recurrent fires facilitate lizard dispersal and migration due to the increased quality of the habitat for wall lizards. At the regional level, we examine whether a recurrent fire regime may disrupt the spatial structure of populations. Our results showed an increase in genetic diversity in recurrently burnt populations, and a decline in longer-unburnt populations. We did not detect bottleneck effects in repeatedly-burnt populations. High genetic diversity in recurrent fire populations suggests a high dispersion rate between adjacent metapopulations and perhaps immigration from outside the fire boundary. At the regional level, lizard populations show low differentiation and weak genetic structure, suggesting no effects of fire. This study confirms field-based censuses showing that recurrent-fire regimes give ecological opportunities to wall lizards that benefit from habitat openness.
Effect of fluoride mouthrinses and stannous ions on the erosion protective properties of the in situ pellicle
Authors: Kensche A. , Buschbeck E. , König B. , Koch M. , Kirsch J. , Hannig C. , Hannig M. 
Published: March 2019

AbstractThe particular feature of this study is the investigation of effects of pure fluoride- or stannous ions based mouthrinses on the erosion protective properties and the ultrastructure of the in situ pellicle (12 volunteers). Experimental solutions were prepared either from 500 ppm NaF, SMFP, AmF or SnF2 or 1563 ppm SnCl2, respectively. After 1 min of in situ pellicle formation on bovine enamel slabs, rinses with one of the preparations were performed for 1 min and intraoral specimens’ exposure was continued for 28 min. Native enamel slabs and rinses with bidestilled water served as controls. After oral exposure, slabs were incubated in HCl (pH 2; 2.3; 3) for 120 s and kinetics of calcium- and phosphate release were measured photometrically; representative samples were analysed by TEM and EDX. All mouthrinses reduced mineral loss compared to the native 30-min pellicle. The effect was pH-dependent and significant at all pH values only for the tin-containing mouthrinses. No significant differences were observed between the SnF2- and the SnCl2-containing solutions. TEM/EDX confirmed ultrastructural pellicle modifications. SnF2 appears to be the most effective type of fluoride to prevent erosive enamel demineralisation. The observed effects primarily have to be attributed to the stannous ions’ content.