bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex‐based differences in histologic lung cancer incidence trends in the United States, 2005–2019
Authors: Burus Todd , Patel Manali I. , Christian W. Jay , Huang Bin , Lang Kuhs Krystle A. 
Published: November 2024

AbstractDecreases in lung cancer incidence in the United States (US) have paralleled decreasing smoking prevalence for several decades; however, recent data has revealed slower declines among females than males. Sex‐based differences in histologic lung cancer—and specifically adenocarcinoma—for all 50 US states and the District of Columbia have never been investigated. Using population‐based cancer registry data from the US Cancer Statistics, we examined age‐adjusted histologic lung cancer incidence rates and trends by sex and state of residence at diagnosis. We compared state‐level adenocarcinoma incidence to lung cancer screening (LCS) adherence and smoking prevalence estimates. Average annual percentage change (AAPC) and incidence rate ratios (IRR) were used to assess changes over time. Nationally, females experienced faster increases in adenocarcinoma incidence than males (1.75%/year vs. 0.35%/year), and slower decreases in incidence of squamous cell (−0.06%/year vs. −1.58%/year) and small cell carcinoma (−2.06%/year vs. −3.19%/year). Adenocarcinoma incidence increased significantly (AAPC>0) in 41 states among females compared to 10 among males. Significant adenocarcinoma increases in individuals under age 55 (IRR >1) occurred among females in six states (four in the southeastern US) and none among males. State‐level LCS adherence was significantly associated with adenocarcinoma incidence among females (r = 0.39; p<.01) but not males, though screening cannot account for increases among females under age 55. Our results highlight sex‐based differences in histologic lung cancer incidence trends, with specific concern for increases in adenocarcinoma in the southeastern US. Further research is needed into appropriate LCS eligibility criteria and the risk factors driving sex‐based disparities.
Total en bloc spondylectomy in testicular immature teratoma: Long‐term survival amidst vertebral metastasis escalated by growing teratoma syndrome
Authors: Tamaki Masahiro , Maruno Kouhei , Hazama Tatsuya , Takahashi Toshifumi , Yamada Yuya , Nakashima Masakazu , Kikkawa Kazuro , Ito Noriyuki 
Published: November 2024

IntroductionWe present a rare case of long‐term survival following metastasectomy for lumbar metastasis with growing teratoma syndrome.Case presentationAn 18‐year‐old man presented with left scrotal mass and lumbago. Alpha‐fetoprotein was elevated to 648.8 ng/mL, while human chorionic gonadotropin and lactate hydrogenase were normal. Pathology of left inguinal orchiectomy revealed immature teratoma, and computed tomography confirmed a single metastasis in the second lumbar vertebra. After two courses of bleomycin, etoposide, cisplatin chemotherapy, alpha‐fetoprotein decreased, but computed tomography confirmed an enlarged lumbar metastasis. A vertebral biopsy demonstrated teratoma with a dominant mature component, and growing teratoma syndrome was suspected. Following additional etoposide, cisplatin chemotherapy, and normalization of alfa‐fetoprotein, total spondylectomy was performed. Vertebral pathology proved mature teratoma. After adjuvant chemotherapy, he has been recurrence‐free for 17 years.ConclusionSpondylectomy of a single metastatic vertebra contributed to long‐term survival in a testicular teratoma case.
How much and how long? The transmission of external shocks on stock market in Chinese hospitality and tourism industry
Authors: Chen Yuan , Yu Qikexin , Yuan Peiwen , Zhao Yeyang 
Published: November 2024

AbstractIn this study, we employ the synthetic control method to evaluate the transmission of external shocks, taking COVID‐19 as an example, on the stock market in the Chinese hospitality and tourism industry, specifically in the catering, hotel, cultural landscape, natural landscape, and travel agency sectors. We find an increasingly negative causal effect on stock returns in all five sectors within 1–2 days after the external shock occurred. However, this impact then gradually shrank, disappearing after 7 days. We also show that the short‐ and long‐term causal effects of the external shock on stock volatility in the above sectors are positive and significant, due to the great uncertainty induced by the pandemic. We examine the sensitivity of stock market reactions and find that hotels are the most vulnerable among the five sectors in terms of the duration of the pandemic's negative impact. Finally, we report that larger firms in the catering and hotel sectors (compared to the other three sectors) show a greater increase in volatility. These findings provide valuable insights into financial market reactions to an external shock and offer implications for crisis management in the hospitality and tourism industry during such events.
YTHDF3 rs7464 A > G polymorphism increases Chinese neuroblastoma risk: A multiple‐center case–control study
Authors: Lin Huiran , Chen Yongping , Chen Liping , Zhang Wenli , Zhu Jinhong , Zhang Xinxin , Yang Zhonghua , Zhang Jiao , Cheng Jiwen , Li Li , Zhou Haixia , Li Suhong , Zhuo Zhenjian , He Jing 
Published: November 2024

AbstractNeuroblastoma (NB), a rare childhood cancer originating in nerve tissue. YTHDF3, a member of the YTH domain protein family, is involved in RNA m6A modification and cancer progression. Polymorphisms in YTHDF3 may influence its expression and biological function. Herein, this study estimated the association between YTHDF3 polymorphisms (rs2241753, rs2241754, and rs7464) and NB susceptibility in a multicenter study comprising 898 cases and 1734 controls. We genotyped YTHDF3 candidate polymorphisms by the TaqMan assay. Logistic regression analysis was applied to indicate the possible relationships between these polymorphisms and NB susceptibility, using odds ratios (ORs) and 95% confidence intervals (CIs). Logistic regression analysis revealed that the rs2241753 GA versus GG decreased NB risk (Adjusted OR = 0.84, 95% CI = 0.71–0.997, p = .047), while the rs7464 GG versus AA enhanced NB risk (Adjusted OR = 1.62, 95% CI = 1.20–2.18, p = .002). Additionally, rs7464 GG versus AA/AG showed a higher risk (Adjusted OR = 1.66, 95% CI = 1.24–2.22, p = .0006). Combination analysis showed that having 1–3 risk genotypes versus 0 was associated with increased NB risk (Adjusted OR = 1.28, 95%CI = 1.09–1.51, p = .003). The significance of rs7464 and the risk genotypes combination persisted across multiple subgroups, whereas rs2241754 was significant only in mediastinal NB. False‐positive report probability (FPRP) confirmed the reliability of results. Notably, the interaction between rs7464 and rs2241754 may increase NB risk dramatically. Our study demonstrated that YTHDF3 rs7464 A > G significantly affected NB susceptibility, warranting validation in larger sample sizes.
Urine Analysed by FTIR, Chemometrics and Machine Learning Methods in Determination Spectroscopy Marker of Prostate Cancer in Urine
Authors: Mitura Przemysław , Paja Wiesław , Klebowski Bartosz , Płaza Paweł , Bar Krzyszof , Młynarczyk Grzegorz , Depciuch Joanna 
Published: November 2024

ABSTRACTProstate‐specific antigen (PSA) is the most commonly used marker of prostate cancer. However, nearly 25% of men with elevated PSA levels do not have cancer and nearly 20% of patients with prostate cancer have normal serum PSA levels. Therefore, in this study, Fourier transform infrared (FTIR) spectroscopy was investigated as a new tool for detection of prostate cancer from urine. Obtained results showed higher levels of glucose, urea and creatinine in urine collected from patients with prostate cancer than that in control. Principal component analysis (PCA) was not noticed possibility of differentiation urine collected from healthy and nonhealthy patients. However, machine learning algorithms showed 0.90 accuracy and precision of FTIR in detection of prostate cancer from urine. We showed that wavenumbers at 1614 cm−1 and 2972 cm−1 were candidates for prostate cancer spectroscopy markers. Importantly, these FTIR markers correlated with Gleason score, PSA and mpMRI PI‐RADS category.
Concordance of Freehand 3D Ultrasound Muscle Measurements With Sarcopenia Parameters in a Geriatric Rehabilitation Ward
Authors: Huet Jeremie , Nordez Antoine , Sarcher Aurélie , Mathieu Marie , Cornu Christophe , Boureau Anne‐Sophie 
Published: November 2024

ABSTRACTBackgroundSarcopenia is a devastating disease for older adults, but it lacks accessible and reliable tools for measuring total appendicular skeletal muscle mass (ASMM). Two‐dimensional muscle ultrasound (US) has been developed for its bedside clinical advantages and feasibility but lacks standardization and prediction performance. We previously validated a new 3D‐US technique to measure muscle volume (MV) at bedside and applied it in a geriatric rehabilitation setting.Objectives were to analyse the concordance between 3D‐US MV and ASMM and compare concordance between 3D‐US MV and 2D‐US parameters with ASMM.MethodsParticipants were recruited in a Geriatric rehabilitation ward in Nantes, France, from May to October 2022. Exclusion criteria were as follows: oedema in the lower limbs or recent history of unilateral lower limb damage or stroke. ASMM was measured with bioelectrical impedance analysis; 3D‐US and 2D‐US acquisitions were performed on three muscles of the right lower limb. Measures of strength (hand grip, knee extension and ankle dorsiflexion) were also recorded. Reliability of 3D‐US MV measurements on 10 participants was high (ICC = 0.99).We used Lin's concordance correlation coefficients (CCC) and bias correction factor for agreement between variables and linear regression models for prediction equations.ResultsFifty‐eight participants had an interpretable ASMM of whom 17 (29%) had a diagnosis of sarcopenia. Volumes of TA, RF and VL were all significantly concordant with ASMM measured by BIA (all p values < 0.001), with CCCs respectively of 0.72, 0.61 and 0.60. MV were all significantly concordant with isometric strength (p values < 0.001). Concordance and correlation with ASMM were higher with 3D‐US than 2D‐US measurements regardless of the muscle. Prediction of ASMM reached an adjusted R2 of 0.8 with tibialis anterior volume, biometrics and 2D measurements.ConclusionsThis study was the first to use 3D‐US in a geriatric setting and develop a model to predict ASMM in very old hospitalized patients. MV measurements with 3D‐US proved to be reliable and more concordant with appendicular muscle mass and strength than 2D parameters.
Impact of intermittent power supply on electrokinetic remediation of chromium‐contaminated soil
Authors: Huang Zhaoqin , Hu LinChao , Ji Dongliang , Feng Xiaowei , Ge Liang 
Published: November 2024

AbstractBACKGROUNDThis study investigates the effectiveness of electrokinetic remediation (EKR) with an intermittent power supply on soil contaminated with varying concentrations of chromium (Cr). Two soil types, designated as Soil A and Soil B, were analyzed to assess the impact of different remediation strategies.RESULTSSoil A, characterized by lower total Cr levels (1137 mg/kg), exhibited Cr (VI) removal rates exceeding 85%, peaking at 90.79% during the EK1 treatment (20 h on/4 h off). In contrast, Soil B, with significantly higher total Cr concentrations (6639 mg/kg), demonstrated a maximum Cr (VI) removal rate of approximately 80%. The study evaluated the influence of current, soil pH, and the three‐dimensional distribution of total Cr, Cr (VI), and Cr (III). Energy consumption increased with longer power‐off durations, while Soil B benefited from reduced energy usage and achieved nearly 10% higher Cr (VI) removal efficiency under specific conditions.CONCLUSIONThe findings demonstrate that EKR with intermittent power supply is an effective and energy‐efficient approach for remediating Cr‐contaminated soils, particularly when tailored to the specific characteristics of the contaminated soil types. © 2024 Society of Chemical Industry (SCI).
Shining a spotlight on youth involvement in mental health research: Challenges and innovations
Authors: Michail Maria 
Published: November 2024

AbstractDespite progress in youth involvement in mental health research, considerable gaps remain in our understanding, conceptualisation, and implementation of involving children and young people in this field. This Editorial Perspective reflects on how these gaps present challenges to our research practices and often serve as barriers to meaningfully involving youth voices and experiences into the research process. We take a critical perspective to recent advances in the field of youth involvement in mental health research, reflected by the studies included in this special issue, and highlight examples of good practice paving the way for more equitable and inclusive approaches. Meaningful progress in mental health research relies on the active involvement of young people. Researchers, practitioners and policymakers have an ethical and moral responsibility to create a safe and inclusive environment that empowers young people to participate in research that impacts their lives, care, and overall quality of life.
Perception of the value of simulation models by dental anesthesia teachers and implementation of simulation models for teaching
Authors: Aguila‐Sánchez Lilia Mariana , Bermeo‐Escalona Josué Roberto , Suárez‐Franco José Luis , Galindo‐Reyes Edith Lilia , Ortiz‐Magdaleno Mariné , Cerda‐Cristerna Bernardino Isaac 
Published: November 2024

AbstractBackgroundA dental anesthesia simulation model (DASM) is a tool for the teaching and learning of local dental anesthesia techniques. We investigated how dental anesthesia teachers (DATs) perceive the value of those tools.ObjectiveThe objective of this study was to investigate the following: the characteristics of the dental anesthesia curriculum used by DATs in Mexico; the DATs’ opinion of ethical issues in the teaching of local dental anesthesia; the DATs’ perception of the value of using a DASM to teach local dental anesthesia; and the characteristics of the implementation of a DASM by DATs.MethodsDental anesthesia teachers in Mexico answered an online questionnaire with 34 items. The questionnaire had five sections that explored the objective of the study. The results were analyzed with a chi‐square test (p < 0.05) or with the Tau‐c test (p < 0.05).ResultsOne hundred twenty dental anesthesia teachers participated in the study.A total of 37.5% perceived a very high value of using a DASM to teach local dental anesthesia. No significant statistical differences were found when the level of perception was analyzed using the variable of whether the participants used a simulation model for teaching. Half of the participants had access to a simulation model, but only 29.2% used a simulation model for teaching. Most of the participants did not know how to use a DASM for teaching.ConclusionDental anesthesia teachers had a positive perception of simulation models. However, they did not use them, nor were they prepared to use them.
Machine learning in knee injury sequelae detection: Unravelling the role of psychological factors and preventing long‐term sequelae
Authors: LIPPS LENE Clément , Frere Julien , Weissland Thierry 
Published: November 2024

AbstractPurposeThis study evaluated the performance of three machine learning (ML) algorithms—decision tree (DT), multilayer perceptron (MLP) and extreme gradient boosting (XGB)—in identifying regular athletes who suffered a knee injury several months to years prior. In addition, the contribution of psychological variables in addition to biomechanical ones in the classification performance of the ML algorithms was assessed, to better identify factors to get back to competitive sport with the lowest possible risk of new knee injury.MethodsA cohort of 96 athletes, 36 with prior knee injuries, practicing an average of 5.7 ± 2.4 h per week, participated in a horizontal force‐velocity test on a ballistic ergometer providing data of force, velocity and power from each lower limb. They also completed a psychological questionnaire, which included components from the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Sport Anxiety Scale (SAS). The three ML algorithms were trained on a thousand different train‐test sets. Also, Shapley values were calculated for each input variable of a data set to highlight its contribution to the prediction from an ML model.ResultsOver a thousand cross‐validations, higher area under the curve (AUC) values were obtained when accounted for the psychological attributes (p < 0.001). Also, higher AUC values were obtained from MLP compared to XGB or DT (p < 0.001). XGB exhibited higher AUC values than DT (p < 0.001).ConclusionsOur results suggested that psychological factors play a more important role in recognition than biomechanical factors, with KOOS and SAS scores ranking high in the list of influential factors. Additionally, the computing stability of MLP could be recommended for classification tasks in the context of knee injuries.Level of EvidenceLevel III.
N‐lauroylglutamates with two and four carboxylate head groups: Their interactions with bovine serum albumin
Authors: Singh Ankita , Gupta Sumedha , Neelakshi  , Gurunarayanan Vinithra , Ramapanicker Ramesh 
Published: November 2024

AbstractN‐lauroyl derivatives of amino acids have widely been reported as environmentally benign surfactants. Although N‐lauroyl‐l‐glutamate is reported in the literature, the effect of the two carboxylate groups in it has not been specifically addressed. In this study, we report the interactions of bovine serum albumin (BSA) with N‐lauroylglutamate (S1) and an N‐lauroyl derivative of a tripeptide of glutamic acid (S2), respectively. The surfactant S1 has two and S2 has four carboxylic acid groups making them different from other N‐lauroyl amino acids, which have just one carboxylic acid group. The aim of this study is to understand the role of the number of carboxylate groups present in these amino acid‐based anionic surfactants while interacting with biomolecules such as BSA. The critical micelle concentration (CMC) of the surfactants were measured both in the presence and absence of BSA using fluorescence spectroscopy. The fluorescence of BSA was quenched on addition of the surfactants. The mechanisms of fluorescence quenching were established by studying the fluorescence at three different temperatures. CD studies were performed to calculate the temperature at which BSA unfolds completely in the presence and absence of the surfactants. Conformational changes in the secondary structure of BSA were also observed on the addition of S1 and S2. The results of these studies are compared with those previously reported for the interactions between BSA and N‐lauroylglycinate. We find that S1 has a lower CMC than S2 and lauroylglycinate. The surfactant S1 stabilized the secondary structure of BSA better at higher temperatures.
Excellent quality acquisition of myofibrillar protein in red shrimp (Solenocera crassicornis) based on regulating the oxidation degree of atmospheric cold plasma treatment
Authors: Chen Yingyun , Peng Siwei , Hu Jiajie , Chen Jing , Zhou Xinyi , Yang Hongli 
Published: November 2024

AbstractBACKGROUNDMyofibrillar protein (MP) is essential for the texture and taste of shrimp surimi products. The reactive oxygen/nitrogen species (ROS/RNS) produced by atmospheric cold plasma (ACP) might cause oxidative modification of MP. In this study, the effect of different ACP treatment times on the properties of red shrimp MP was investigated in detail.RESULTSThe mild oxidation induced by ACP treatment for 1 min (ACP‐1 min) promoted the unfolding and refolding of the MP structure, which was manifested as a transition from α‐helix to β‐sheets. Compared with other groups, more hydrogen bonds and hydrophobic interactions in the ACP‐1 min group might enhance the interactions between the myosin heavy chain and actin, which was conducive to the formation of a regular and dense three‐dimensional network structure. Person correlation analysis revealed that ROS/RNS mediated the changes in the secondary and tertiary structure of MP. In addition, ACP‐1 min has high Ca2+‐ATPase activity, which reflected that MP maintained structural integrity. While excessive oxidation in the ACP treatments for 3 min and 5 min reduced MP robustness. The stable internal structure in ACP‐1 min group gave the MP excellent texture profile (1.79 mJ of adhesiveness and 0.89 mm of springiness) and rheological characteristics (0.373 MPa of storage modulus).CONCLUSIONOverall, the excellent quality of MP could be obtained by regulating the oxidation degree of ACP, which would provide valuable information for the in‐depth and efficient processing of shrimp products. © 2024 Society of Chemical Industry.
A Systematic Review and Meta‐Analysis of Oncologic Liver Resections in Low‐ and Middle‐Income Countries: Opportunities to Improve Evidence and Outcomes
Authors: Khan Adel H. , Mahmud Omar , Fatimi Asad Saulat , Ahmed Shaheer , Wiener Alyssa A. , Nishtala Madhuri V. , Stahl Christopher C. , Christensen Leslie , Khan Muhammad Rizwan , Schwartz Patrick B. , Zafar Syed Nabeel 
Published: November 2024

ABSTRACTBackgroundPatients in low‐ and middle‐income countries (LMICs) are disproportionately affected by liver cancers but there is a lack of understanding of their postoperative outcomes. This study aimed to review the current status of research in LMICs regarding outcomes after oncologic hepatectomy and synthesize the data reported in the literature.MethodsThe PubMed, Scopus, Embase, Web of Science, and World Health Organization (WHO) Global Index Medicus databases were searched from database inception to May 26th, 2022. Studies that reported outcomes after oncologic hepatectomy in LMIC settings were eligible for inclusion. Two independent reviewers performed record screening and data extraction. Risk of bias assessment was performed using the National Institutes of Health Study Quality Assessment tools. Pooled results with 95% confidence intervals (95% CIs) were calculated using a random effects model.ResultsOne hundred and thirty‐five studies and 16 985 patients were included. Most studies were of a “fair” quality. Two studies described pediatric patients. Only one study was from a low‐income country and most African regions were not represented. The rates of major and minor complications were 11% and 27%, respectively, while 30‐ and 90‐day mortality rates were 2% and 3% each. Postoperative liver failure (8%), surgical site infections (6%), and bile leaks (6%) were common complications.ConclusionsThis review indicates a dearth of data from LMICs on outcomes after hepatectomy, particularly from African regions and low‐income countries.
Averaging principle on semi‐axis for semi‐linear differential equations
Authors: Cheban David 
Published: November 2024

AbstractWe establish an averaging principle on the real semi‐axis for semi‐linear equation
with unbounded closed linear operator and asymptotically Poisson stable (in particular, asymptotically stationary, asymptotically periodic, asymptotically quasi‐periodic, asymptotically almost periodic, asymptotically almost automorphic, asymptotically recurrent) coefficients. Under some conditions, we prove that there exists at least one solution, which possesses the same asymptotically recurrence property as the coefficients, in a small neighborhood of the stationary solution to the averaged equation, and this solution converges to the stationary solution of averaged equation uniformly on the real semi‐axis when the small parameter approaches to zero.