bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biting mechanics determines craniofacial morphology among extant diprotodont herbivores: dietary predictions for the giant extinct short-faced kangaroo, Simosthenurus occidentalis
Authors: Mitchell D. Rex , Wroe Stephen 
Published: January 2019

AbstractLarge herbivores can act as keystone species that strongly influence their communities. During the Pliocene and Pleistocene, Australia was dominated by a number of large to gigantic marsupial herbivore taxa. Many of these have been understudied quantitatively with regard to their ecology; and identifying the diet of these species will improve our understanding of not only their ecologies, but also of past environments. Recent research has found that cranial morphology among kangaroos and wallabies corresponds with foraging behaviors and mechanical properties of preferred plant tissues. Here we apply shape analysis and computational biomechanics to test the hypothesis: that feeding ecology is associated with craniofacial morphology across a taxonomically broad sample of diprotodont herbivores. Based on our results we predict the diet of an extinct short-faced kangaroo, Simosthenurus occidentalis. We find that biting behaviors are reflected in craniofacial morphology, but that these are more a reflection of the hardest bites required for their lifestyle, rather than diet composition alone. A combination of a very short face, robust musculoskeletal features, and dental arrangements predict that S. occidentalis was a browser, capable of consuming particularly resistant, bulky plant matter. These features were largely conserved among other short-faced kangaroos and may have offset the unpredictable availability of quality forage during the climatically variable Pleistocene epoch, contributing to their prolific diversification during this time.
TRADING SECRETS: CONSTRUCTIONS AND CONTEXTS OF TWO MIDDLE EASTERN JEWISH GUARDS IN THE EARLY PETAH TIKVA AGRICULTURAL COLONY
Authors: Halperin Liora R. 
Published: January 2019

AbstractTwo Arabic-speaking Jewish guards worked in the European Jewish agricultural colony of Petah Tikva soon after its founding, northeast of Jaffa, in 1878: Daud abu Yusuf from Baghdad and Yaʿqub bin Maymun Zirmati, a Maghribi Jew from Jaffa. The two men, who worked as traders among Bedouin but were recruited for a short time by the colony, offer a rare glimpse of contacts between Ashkenazi and Middle Eastern Jews in rural Jewish colonies established in the last quarter of the 19th century, colonies that are often regarded as detached from their local and Ottoman landscape. The article first argues that Zionist sources constructed these two men as bridges to the East in their roles as teachers of Arabic and perceived sources of legitimization for the European Jewish settlement project. It then reads beyond the sparse details offered in Ashkenazi Zionist sources to resituate these men in their broad imperial and regional context and argue that, contrary to the local Zionist accounts, the colony was in fact likely to have been marginal to these men's commercial and personal lives.
The Other Door: Spain and the Guatemalan Counter-Revolution, 1944–54
Authors: Weld Kirsten 
Published: January 2019

AbstractThis article reveals the influence of the Spanish Civil War (1936–9) on both the reformers of Guatemala's ‘Revolutionary Spring’ (1944–54) and the reactionaries who overthrew Jacobo Arbenz in 1954. It shows how officials in the Arévalo and Arbenz administrations looked to the defeated Second Spanish Republic as a moral and political example, while local opponents of those administrations treated Spain's Nationalist insurgency and Francisco Franco's dictatorship as models for how to exterminate communism. In so doing, the article argues for the importance of multi-sited transnational Cold War histories that complement existing studies of US intervention.
In vitroscreening of 51 birdsfoot trefoil (Lotus corniculatusL.; Fabaceae) strains for anti-parasitic effects againstHaemonchus contortus
Authors: Barone Carly D. , Zajac Anne M. , Ferguson Sarah M. , Brown Rebecca N. , Reed Jess D. , Krueger Christian G. , Petersson Katherine H. 
Published: January 2019

AbstractSecondary plant compounds have shown bioactivity against multi-drug resistantHaemonchus contortusin small ruminants. This study screened 51 strains of birdsfoot trefoil (BFT,Lotus corniculatus) crude aqueous extracts (BFT-AqE) for anti-parasitic activityin vitroagainst egg hatching, and of those 51 strains, 13 were selected for further testing of motility of first (L1) and third stage (L3) larvae, and exsheathment of L3. Proanthocyanidin content ranged between 1.4 and 63.8 mg PAC g−1powder across the 51 BFT strains. When tested against egg hatching, 21 of the 51 aqueous extracts had an EC50of 1–2 mg powder mL−1, 70% of the strains were >90% efficacious at 6 mg powder mL−1and 11 of the strains were 100% efficacious at 3 mg powder mL−1BFT-AqE. Across the 13 strains tested against L3, efficacy ranged from 0 to 75% exsheathment inhibition, and 17 to 92% L3 motility inhibition at a concentration of 25 mg powder mL−1BFT-AqE. There was no correlation between the PAC content of BFT powders and the anti-parasitic activity of aqueous extracts, therefore other secondary compounds may have contributed to the observed anti-parasitic effects. Further testing of BFT using bioactivity-driven fractionation and screening of BFT populations for the identified anti-parasitic compounds is needed.
From Rights to Activation: The Evolution of the Idea of Basic Income in the Finnish Political Debate, 1980–2016
Authors: PERKIÖ JOHANNA 
Published: January 2019

AbstractThe article contributes to the growing body of research on the politics of basic income by analysing the framing of the idea in the context of Finland, a country with a long history of debate and one of the forerunners in experimenting with this policy. Using a comprehensive dataset of political documents covering 36 years, the study shows how contextual factors and shifts in political climate shaped the framing of the idea. It also shows that the key frames describing basic income were widely shared among the politicians and parties discussing the policy. The study enriches our understanding of the politics of basic income by adding an ideational perspective that has for long been a missing element in this field of research.
BAYESIAN OCKHAM’S RAZOR AND NESTED MODELS
Authors: Autzen Bengt 
Published: January 2019

Abstract:While Bayesian methods are widely used in economics and finance, the foundations of this approach remain controversial. In the contemporary statistical literature Bayesian Ockham’s razor refers to the observation that the Bayesian approach to scientific inference will automatically assign greater likelihood to a simpler hypothesis if the data are compatible with both a simpler and a more complex hypothesis. In this paper I will discuss a problem that results when Bayesian Ockham’s razor is applied to nested economic models. I will argue that previous responses to the problem found in the philosophical literature are unsatisfactory and develop a novel reply to the problem.
Dimensions in programming multi-agent systems
Authors: Boissier Olivier , Bordini Rafael H. , Hübner Jomi F. , Ricci Alessandro 
Published: January 2019

Abstract
Research on Multi-Agent Systems (MAS) has led to the development of several models, languages, and technologies for programming not only agents, but also their interaction, the application environment where they are situated, as well as the organization in which they participate. Research on those topics moved from agent-oriented programming towards multi-agent-oriented programming (MAOP). A MAS program is then designed and developed using a structured set of concepts and associated first-class design and programming abstractions that go beyond the concepts normally associated with agents. They include those related to environment, interaction, and organization. JaCaMo is a platform for MAOP built on top of three seamlessly integrated dimensions (i.e. structured sets of concepts and associated execution platforms): for programming belief desire intention (BDI) agents, their artefact-based environments, and their normative organizations. The key purpose of our work on JaCaMo is to support programmers in exploring the synergy between these dimensions, providing a comprehensive programming model, as well as a corresponding platform for developing and running MAS. This paper provides a practical overview of MAOP using JaCaMo. We show how emphasizing one particular dimension leads to different solutions to the same problem, and discuss the issues of each of those solutions.
The fifth moment of Hecke L-functions in the weight aspect
Authors: KHAN RIZWANUR 
Published: January 2019

AbstractWe prove an upper bound for the fifth moment of Hecke L-functions associated to holomorphic Hecke cusp forms of full level and weight k in a dyadic interval K ≤ k ≤2K, as K → ∞. The bound is sharp on Selberg’s eigenvalue conjecture.
Self-selection and risk sharing in a modern world of life-long annuities
Authors: Gerrard R. , Hiabu M. , Kyriakou I. , Nielsen J. P. 
Published: January 2019

AbstractCommunicating a pension product well is as important as optimising the financial value. In a recent study, we showed that up to 80% of the value of a pension lump sum could be lost if customer communication failed. In this paper, we extend the simple customer interaction of the earlier contribution to the more challenging lifetime annuity case. Using a simple mobile phone device, the pension customer can select the life-long optimal investment strategy within minutes. The financial risk trade-off is presented as a trade-off between the pension paid and the number of years the life-long annuity is guaranteed. The pension payment decreases when investment security increases. The necessary underlying mathematical financial hedging theory is included in the study.
Moderately elevated preconception fasting plasma total homocysteine is a risk factor for psychological problems in childhood
Authors: Roigé-Castellví Joana , Murphy Michelle , Fernández-Ballart Joan , Canals Josefa 
Published: January 2019

AbstractObjectiveWe investigated the effect of maternal preconception fasting plasma total homocysteine (tHcy) on psychological problems in children aged 6 years from normal pregnancies.DesignA longitudinal study was carried out from preconception, throughout each trimester of pregnancy, until 6 years of age in the offspring. Fasting blood samples at 2–10 weeks preconception and non-fasting samples at birth were collected. Parents completed the Child Behaviour Checklist (CBCL) and teachers the Inattention-Overactivity with Aggression (IOWA) scale for the 6-year-old children.SettingElevated tHcy during pregnancy has been associated with several adverse outcomes and with neurodevelopmental impairment in the offspring.ParticipantsThe initial sample consisted of 139 healthy non-pregnant women who were planning on becoming pregnant. Eighty-one mother–child dyads were followed from preconception until 6 years of age.ResultsAfter adjusting for covariables, multiple linear regression models showed that higher preconception tHcy was associated with higher scores in internalizing dimension (β=0·289;P=0.028), specifically in withdrawn behaviour (β=0·349;P=0·009), anxiety/depression (β=0·303;P=0·019) and social problems (β=0·372;P=0·009). Aggressive behaviour in the school setting was higher in children whose mothers had higher preconception tHcy (β=0·351;P=0·014).ConclusionsModerately elevated preconception tHcy may increase the risk of psychological problems in offspring during childhood. These findings add to the evidence that maternal nutritional status, even before being pregnant, can affect later offspring health and may be important to consider when developing future public health policy.
Dosimetric comparison of flattened and flattening filter-free beams for liver stereotactic body irradiation in deep inspiration breath hold, and free breathing conditions
Authors: Munirathinam N. , Pawaskar P. N. 
Published: January 2019

AbstractAimThe aim of this study is to evaluate the influence of flattened and flattening filter-free (FFF) beam 6 MV photon beam for liver stereotactic body radiation therapy by using volumetric modulated arc therapy (VMAT) technique in deep inspiration breath hold (DIBH) and free breathing condition.Materials and methodsEight liver metastasis patients (one to three metastasis lesions) were simulated in breath hold and free breathing condition. VMAT-based treatment plans were created for a prescription dose of 50 Gy in 10 fractions, using a 230° coplaner arc and 60° non-coplanar arc for both DIBH and free breathing study set. Treatment plans were evaluated for planning target volume (PTV) dose coverage, conformity and hot spots. Parallel and serial organs at risk were compared for average and maximum dose, respectively. Dose spillages were evaluated for different isodose volumes from 5 to 80%.ResultMean D98% (dose received by 98% target volume) for FFF in DIBH, flattened beam in DIBH, FFF in free breathing and flatten beam in free breathing dataset were 48·9, 47·81, 48·5 and 48·3 Gy, respectively. D98% was not statistically different between FFF and flatten beam (p = 0·34 and 0·69 for DIBH and free breathing condition). PTV V105% (volume receiving 105% dose) for the same set were 3·76, 0·25, 1·2 and 0·4%, respectively. Mean heterogeneity index for all study sets and beam models varies between 1·05 and 1·07. Paddik conformity index using unflattened and flattened beam in DIBH at 98% prescription dose were 0·91 and 0·79, respectively. Maximum variation of isodose volume was observed for I-5%, which was ranging between 2288·8 and 2427·2 cm3. Increase in isodose value shows a diminishing difference in isodose volumes between different techniques. DIBH yields a significant reduction in the chest wall dose compared with free breathing condition. Average monitor units for FFF beam in DIBH, flattened beam in DIBH, FFF beam in free breathing CT dataset and flattened beam in free breathing CT dataset were 1318·6 ± 265·1, 1940·3 ± 287·6, 1343·3 ± 238·1 and 2192·5 ± 252·6 MU.ConclusionDIBH and FFF is a good combination to reduce the treatment time and to achieve better tumour conformity. No other dosimetric gain was observed for FFF in either DIBH or free breathing condition.
Patient experience of supported computerized CBT in an inner-city IAPT service: a qualitative study
Authors: Perera-Delcourt Ramesh P. , Sharkey Gemma 
Published: January 2019

AbstractComputerized cognitive behavioural therapy (cCBT) has been developed to address economic and clinical issues around limited access to evidence-based therapy. Supported cCBT (variously termed iCBT or eCBT) has been developed to address issues with the effectiveness of, and engagement with, cCBT. There has been no in-depth qualitative exploration of the patient experience of eCBT within the UK, which might aid improving its effectiveness. The aim of this study was to explore patient experience of eCBT in one inner-city National Health Service (NHS) Improving Access to Psychological Therapies (IAPT) service using a semi-structured interview and Thematic Analysis methodology. Ten patients took part. Six main themes were identified: (1) Being Offered eCBT; (2) How eCBT Compares with Self-help; (3) The Patient's State of Mind; (4) The Relationship with the Supporter; (5) Preferring to Talk; (6) eCBT's Value as a Treatment. Participants in this study indicated a preference for face-to-face talking therapy, but were clear that they could form a therapeutic relationship via asynchronous messaging. They reported clinical benefit from the eCBT programme and online relationship, and acknowledged that accessing this immediately was valuable. Issues around the process of selecting patients for eCBT, including with regard to acknowledging or mitigating any negative emotional effects of eCBT, and how to offer and support users with it, are discussed.
Time reversal imaging based on joint space–frequency and frequency–frequency data
Authors: Mu Tong , Song Yaoliang 
Published: January 2019

AbstractA new time reversal (TR) method for target imaging is proposed in this paper. Through single measurement by the antenna array, the received signals are utilized to form the space–frequency–frequency multistatic data matrix (MDM). Singular value decomposition is applied to the matrix to obtain the left singular vectors which span the signal subspace. The obtained vectors are divided into multiple subvectors by two different schemes and used to provide target signatures in the form of coarse frequency dependence and relative phase shifts that can be exploited to construct the imaging function. The performance of the proposed method is investigated through numerical simulations for both single and multiple targets, and the results are compared with the traditional TR method using the frequency–frequency MDM. It turned out that the proposed method is able to achieve high resolution with limited array aperture and shows satisfactory robustness in noise environment. Furthermore, experimental results are provided to show the availability of the method in practical applications.
3‐D Density, Thermal, and Compositional Model of the Antarctic Lithosphere and Implications for Its Evolution
Authors: Haeger C. , Kaban M. K. , Tesauro M. , Petrunin A. G. , Mooney W. D. 
Published: January 2019

AbstractWe create a 3‐D density, temperature, and composition model of the Antarctic lithosphere using an integrative approach combining gravity, topography, and tomography data with mineral physics constraints and seismic data on crustal structures. The latter is used to create a new Moho and crustal density model. Temperature and thermal density variations are estimated based on S wave velocities from two independent tomography models (SL2013sv and AN1‐S). Results of the Antarctic continent show the well‐known distinction between East and West Antarctica in temperature and density to a depth of about 200 km. Incorporating compositional variations in the temperature calculations increases temperatures in depleted regions by up to 150 °C, giving improved insights into thermal structures. The thickness of the lithospheric root also varies strongly between these regions, with values below 100 km in the west and above 200 km in the east. Regions with negative compositional density variations (<−0.040 g/cm3 at 100 km), high depletion (Mg # > 91.5), and low temperatures (<800 °C; central Dronning Maud Land, along the east flank of the Transantarctic Mountains) are interpreted as Precambrian cratonic fragments. Nearly undepleted lithosphere is found in the Lambert Graben and the Aurora Subglacial Basin and is attributed to Mesozoic rifting activity that has caused lithospheric rejuvenation.
Functional annotation of orthologs in metagenomes: a case study of genes for the transformation of oceanic dimethylsulfoniopropionate
Authors: González José M , Hernández Laura , Manzano Iris , Pedrós-Alió Carlos 
Published: January 2019

Abstract
Dimethylsulfoniopropionate (DMSP) is produced mainly by phytoplankton and bacteria. It is relatively abundant and ubiquitous in the marine environment, where bacterioplankton make use of it readily as both carbon and sulfur sources. In one transformation pathway, part of the molecule becomes dimethylsulfide (DMS), which escapes into the atmosphere and plays an important role in the sulfur exchange between oceans and atmosphere. Through its other dominant catabolic pathway, bacteria are able to use it as sulfur source. During the past few years, a number of genes involved in its transformation have been characterized. Identifying genes in taxonomic groups not amenable to conventional methods of cultivation is challenging. Indeed, functional annotation of genes in environmental studies is not straightforward, considering that particular taxa are not well represented in the available sequence databases. Furthermore, many genes belong to families of paralogs with similar sequences but perhaps different functions. In this study, we develop in silico approaches to infer protein function of an environmentally important gene (dmdA) that carries out the first step in the sulfur assimilation from DMSP. The method combines a set of tools to annotate a targeted gene in genome databases and metagenome assemblies. The method will be useful to identify genes that carry out key biochemical processes in the environment.
DNA methylation in mice is influenced by genetics as well as sex and life experience
Authors: Grimm Sara A. , Shimbo Takashi , Takaku Motoki , Thomas James W. , Auerbach Scott , Bennett Brian D. , Bucher John R. , Burkholder Adam B. , Day Frank , Du Ying , Duncan Christopher G. , French John E. , Foley Julie F. , Li Jianying , Merrick B. Alex , Tice Raymond R. , Wang Tianyuan , Xu Xiaojiang ,   NISC Comparative Sequencing Program, Barnabas Beatrice B. , Bouffard Gerard G. , Brooks Shelise Y. , Coleman Holly , Dekhtyar Lyudmila , Guan Xiaobin , Han Joel , Ho Shi-ling , Legaspi Richelle , Maduro Quino L. , Masiello Catherine A. , McDowell Jennifer C. , Montemayor Cassandra , Park Morgan , Riebow Nancy L. , Schandler Karen , Scharer Chanthra , Schmidt Brian , Sison Christina , Stantripop Sirintorn , Thomas Pamela J. , Vemulapalli Meghana , Young Alice C. , Bushel Pierre R. , Fargo David C. , Mullikin James C. , Wade Paul A. 
Published: January 2019

AbstractDNA methylation is an essential epigenetic process in mammals, intimately involved in gene regulation. Here we address the extent to which genetics, sex, and pregnancy influence genomic DNA methylation by intercrossing 2 inbred mouse strains, C57BL/6N and C3H/HeN, and analyzing DNA methylation in parents and offspring using whole-genome bisulfite sequencing. Differential methylation across genotype is detected at thousands of loci and is preserved on parental alleles in offspring. In comparison of autosomal DNA methylation patterns across sex, hundreds of differentially methylated regions are detected. Comparison of animals with different histories of pregnancy within our study reveals a CpG methylation pattern that is restricted to female animals that had borne offspring. Collectively, our results demonstrate the stability of CpG methylation across generations, clarify the interplay of epigenetics with genetics and sex, and suggest that CpG methylation may serve as an epigenetic record of life events in somatic tissues at loci whose expression is linked to the relevant biology.
LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation
Authors: Profumo Valentina , Forte Barbara , Percio Stefano , Rotundo Federica , Doldi Valentina , Ferrari Elena , Fenderico Nicola , Dugo Matteo , Romagnoli Dario , Benelli Matteo , Valdagni Riccardo , Dolfini Diletta , Zaffaroni Nadia , Gandellini Paolo 
Published: January 2019

AbstractThough miR-205 function has been largely characterized, the nature of its host gene, MIR205HG, is still completely unknown. Here, we show that only lowly expressed alternatively spliced MIR205HG transcripts act as de facto pri-miRNAs, through a process that involves Drosha to prevent unfavorable splicing and directly mediate miR-205 excision. Notably, MIR205HG-specific processed transcripts revealed to be functional per se as nuclear long noncoding RNA capable of regulating differentiation of human prostate basal cells through control of the interferon pathway. At molecular level, MIR205HG directly binds the promoters of its target genes, which have an Alu element in proximity of the Interferon-Regulatory Factor (IRF) binding site, and represses their transcription likely buffering IRF1 activity, with the ultimate effect of preventing luminal differentiation. As MIR205HG functions autonomously from (albeit complementing) miR-205 in preserving the basal identity of prostate epithelial cells, it warrants reannotation as LEADeR (Long Epithelial Alu-interacting Differentiation-related RNA).