bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Bridge Symptoms of Work–Family Conflict, Sleep Disorder, and Job Burnout: A Network Analysis
Authors: Sun Jingyan , Wang Siyuan , Huang Ying , Lam Sze Tung , Zhao Yixin , He Yuqiong , Peng Hanrui , Guo Huijuan , Wang Xiaoping 
Published: November 2024

Background: This study aims to elucidate characteristics of the symptom network of work–family conflict (WFC) and sleep disorders among Chinese correctional personnels while accounting for job burnout as a possible confounder.Method: A total of 472 correctional personnel were included. Their WFC, sleep disorders, and job burnout were measured using a Chinese version of Work–Family Conflict Scale (WFCS), the Athens Insomnia Scale (AIS), and a revised Chinese version of Maslach Burnout Inventory‐General Survey (MBI‐GS), respectively. Central symptoms and bridge symptoms were respectively identified based on centrality indices and bridge centrality indices. Network stability was examined using the case‐dropping procedure.Results: Daytime condition (strength = 0.01) and strain‐based work interference with family (WFCs, strength = 1.45) symptoms had the highest centrality values in the WFC‐sleep disorder network structure, which were also identified as two bridge symptoms. Emotional exhaustion, daytime condition, and WFCs appeared to be potential bridge symptoms in the WFC–sleep disorder–burnout network structure.Conclusions: In this study, among Chinese correctional personnel, daytime conditions, and WFCs were found to be central symptoms in the WFC–sleep disorder network structure, with emotional exhaustion as the bridge symptom in the WFC–sleep disorder–burnout network structure. We encourage relevant organizations to provide timely and effective education and guidance for regulatory personnel regarding these bridge symptoms. Subsequent research should follow up to assess the impact of relevant interventions on symptoms in the WFC–sleep disorder–burnout network, thereby advocating for the mental and physical health of correctional personnel.
The Challenges of Implementing Good Health and Well‐Being During a Pandemic: A Case Study of the Behavior of Using Telemedicine Services in the Younger Generation
Authors: Parahyanti Endang , Zharifah Afiyah Tsarwat , Lazuardi Sinan Vidi 
Published: November 2024

Objectives: Telemedicine has emerged as a crucial tool in addressing public health requirements, particularly during a pandemic. This aligns with the third Sustainable Development Goals (SDGs) objective of ensuring healthy lives and promoting well‐being for all ages. The current generation demonstrates a greater proficiency in modern technology, prompting researchers to investigate their views and behavior trends in telemedicine.Methods: This research is aimed at examining the telemedicine adoption patterns of Generation Y and Generation Z by dividing them into two groups. Study Group 1 is comprised of those who have known modern technology but have yet to gain experience in using telemedicine. Meanwhile, Study Group 2 is comprised of those who had used telemedicine services. Utilizing structural equation model (SEM) analysis, this research investigates the magnitude of influence exerted by various determinants on an individual’s tendency to utilize telemedicine.Results: Findings from both study groups indicate that younger generations have positive attitudes towards telemedicine, significantly influencing their willingness to use telemedicine. Furthermore, the level of readiness for change emerges as a crucial factor in determining the degree of affective commitment to change, continuance commitment to change, and normative commitment to change. In addition, the participants’ affective experience state significantly influences all three dimensions of commitment to change.Conclusion: The results suggest the importance of fostering a positive and pragmatic understanding of telemedicine among young people. This can be achieved by encouraging the use of telemedicine services and fully adopting the shift to telemedicine. Therefore, it is crucial to prioritize the development of a positive view towards telemedicine, provide excellent service experiences, and promote social flexibility to attract a large user base, especially among the younger population.
Postshift Hand Fatigue in Emergency Service Nurses
Authors: Ulupınar Fadime , Meler Sibel , Karasu Şeyda , Ulupınar Süleyman 
Published: November 2024

Objective: Hand functionality, defined as the ability to perform tasks requiring fine motor skills, is crucial for emergency service nurses as it directly affects their ability to perform tasks requiring fine motor skills, such as administering medication, operating equipment, and providing patient care. This study, therefore, aimed to investigate the effects of an 8‐h work shift on hand functionality and perceived exertion among emergency service nurses.Method: Employing a cross‐sectional design, the study measured manual dexterity, handgrip, and pinch strength, and perceived exertion using the Minnesota Manual Dexterity Test (MMDT), Nine‐Hole Peg Test (9‐HPT), Handgrip Strength Test, Pinch Strength Test, and the Borg Rating of Perceived Exertion (RPE) Scale. Data were collected from 34 emergency service nurses both before and after their shifts.Results: The present findings indicated significant postshift declines in manual dexterity as evidenced by the MMDT and 9‐HPT, with the former demonstrating a large effect size and the latter a small effect size. No significant changes were observed in handgrip and pinch strength. Notably, Borg RPE scores increased significantly postshift, indicating substantial perceived fatigue with a nearly perfect effect size. Correlation analyses revealed significant relationships between increased physical exertion and changes in hand dexterity and strength, underscoring the physical demands placed on nurses during typical work shifts.Conclusions: These findings highlight the need for healthcare institutions to reassess work schedules and ergonomic practices to mitigate fatigue and preserve nurses’ hand functionality, thereby enhancing patient care and nurse well‐being. The study calls for further research to explore more comprehensive strategies aimed at reducing the occupational strain on emergency service nurses.
Supplementary Figure 11 from Organ-Specific Immune Setpoints Underlie Divergent Immune Profiles across Metastatic Sites in Breast Cancer
Authors: Egelston Colt A. , Guo Weihua , Simons Diana L. , Ye Jian , Avalos Christian , Solomon Shawn T. , Nwangwu Mary , Nelson Michael S. , Tan Jiayi , Bacon Eliza R. , Ihle Kena , Schmolze Daniel , Tumyan Lusine , Waisman James R. , Lee Peter P. 
Published: November 2024

<p>Evaluation of immune densities in segmented tissue areas across different organ sites. Densities of phenotype immune cells within segmented areas were compared across tumor-involved organ sites as shown (A, B). Statistics generated by Kruskal–Wallis test by ranks (A ) and Wilcoxon rank sum tests (B). Calculated p values are displayed as *, p < 0.05.</p>
Clinical Significance of Optical Coherence Tomography–Guided Percutaneous Coronary Intervention for In‐Stent Restenosis Within Drug‐Eluting Stents: Impact on Patient Outcomes
Authors: Han Yan , Yuan Xiaohang , Wang Wei , Wang Ningyuan , Zhang Yingqian , Jing Jing , Chen Yundai , Gao Lei 
Published: November 2024

Background
The evidence for optical coherence tomography (OCT)–guided percutaneous coronary intervention (PCI) in improving the prognosis of individuals with in‐stent restenosis (ISR) is lacking.

Methods and Results

This retrospective study enrolled 588 consecutive individuals with drug‐eluting stent ISR undergoing PCI from March 2010 to March 2022. Two hundred seven (35.2%) underwent OCT guidance, and 381 (64.8%) underwent angiography guidance. Clinical outcomes were analyzed using survival curves. The primary clinical endpoint was 2‐year major adverse cardiovascular events (MACEs), a composite of all‐cause death, myocardial infarction, and target‐vessel revascularization. Compared with angiography guidance, OCT guidance demonstrated a higher frequency of drug‐coated balloon use and adjunctive therapeutic modalities, including predilation, postdilation, nonslip element balloons, and noncompliant balloons (
P
<0.05). Following PCI, the OCT‐guided group achieved a significantly larger minimum lumen diameter (2.36 versus 2.15 mm,
P
<0.001) and a lower percentage diameter stenosis (17% versus 20%,
P
<0.001) than the angiography‐guided group. Survival analysis revealed significantly lower 2‐year MACEs in the OCT‐guided group compared with the angiography‐guided group (7% versus 15%,
P
=0.007), validated in the propensity matching analysis (7% versus 15%,
P
=0.001). Multiple sensitivity analyses showed that OCT‐guided PCI treatment was an independent protective factor for 2‐year MACEs in individuals with drug‐eluting stent ISR.

Conclusions
Compared with angiography guidance, OCT guidance is associated with a lower 2‐year MACE risk among individuals with drug‐eluting stent ISR. Therefore, OCT should be actively considered for guiding PCI treatment in individuals with drug‐eluting stent ISR.

Registration

Url:
clinicaltrials.gov
. Identifier: NCT03809754.
Effect of Intravenous Tirofiban Versus Placebo on First‐Pass Successful Reperfusion in Endovascular Stroke Thrombectomy: Insights From the RESCUE BT Randomized Clinical Trial
Authors: Yuan Junjie , Ge Hanming , Tao Zhaojun , An Huijie , Han Qin , Saver Jeffrey L. , Nguyen Thanh N. , Zhou Simin , Mao An , Wu Yuelu , Nogueira Raul Gomes , Sun Yaxuan , Jiang Shunfu , Wei Liping , Fu Xinmin , Bai Yongjie , Yang Shunyu , Hu Wei , Zhang Guling , Pan Chengde , Zhang Shuai , Qiao Lin , Chen Qiong , Sang Hongfei , Qiu Zhongming , Wu Fengfu , Chang Mingze , Ruan Zhongfan 
Published: November 2024

Background
First‐pass successful reperfusion (FPSR), defined as a successful/complete reperfusion achieved after a single thrombectomy pass, is predictive of favorable outcome in patients with acute ischemic stroke with large‐vessel occlusion. It is unknown whether intravenous tirofiban is effective in increasing the rate of FPSR in acute anterior large‐vessel occlusion stroke.

Methods and Results

Patients who had acute large‐vessel occlusion stroke presenting within 24 hours and underwent endovascular thrombectomy were analyzed from the RESCUE BT (Intravenous Tirofiban for Patients With Large Vessel Occlusion Stroke) clinical trial, of which the main analysis was neutral. The RESCUE BT trial randomized patients to receive either intravenous tirofiban or placebo before endovascular thrombectomy. The primary end point was FPSR, defined as successful reperfusion (extended thrombolysis in cerebral infarction scale 2b50, 2c, or 3) at first thrombectomy attempt. A modified Poisson regression analysis assessed the association between intravenous tirofiban treatment and FPSR. Of 948 enrolled patients, 463 patients were randomized to the tirofiban group and 485 to the placebo group. The mean age was 67 years, and 41.0% of the patients were women. FPSR was achieved more often in the tirofiban group (30.5% versus 23.5%; adjusted risk ratio, 1.24 [95% CI, 1.01–1.51];
P
=0.04). FPSR was associated with a favorable shift to lower modified Rankin Scale disability levels at 90 days (common odds ratio, 1.42 [95% CI, 1.08–1.86];
P
=0.01).

Conclusions
In this post hoc analysis of the RESCUE BT trial, treatment with intravenous tirofiban before endovascular thrombectomy was associated with increased FPSR in patients with acute ischemic stroke due to large‐vessel occlusion in the anterior circulation. FPSR was associated with reduced 90‐day levels of disability.

Registration

URL:
http://chictr.org
; Unique Identifier: ChiCTR‐INR‐17014167.
Biography and contributions of Joaquim do Espírito Santo (1901-1984) to the botany of Guinea-Bissau and São Tomé and Príncipe
Authors: LIMA RICARDO FAUSTINO DE , SILVA VASCO , DUARTE MARIA CRISTINA , CATARINO LUÍS 
Published: November 2024

A biography of Joaquim Viegas da Graça do Espírito Santo (1901–1984) is provided by integrating information from botanical collections and from his record as a civil servant. Born in São Tomé Island (São Tomé and Príncipe), he finished his studies in Portugal in 1924, spent most of his career as an agricultural technical engineer in Guinea-Bissau (1927–1956), and after retiring continued collecting, mostly in São Tomé. He collected at least 5 412 herbarium specimens, including 23 types of plant names. He remains the most prolific plant collector in Guinea-Bissau and is a somewhat neglected collector in São Tomé and Príncipe. He also produced 22 publications. Finally, these contributions are contextualised, taking into consideration that he was one of the few non-white plant collectors from the Portuguese colonial period, while being a member of a family that was pivotal in the inception of independence movements in Lusophone Africa.
Functional Outcomes of Immediate Weightbearing After Arthroscopic Lateral Ankle Ligament Repair: A Prospective Randomized Single-Center Trial
Authors: Zhao Yujie , Gu Xicheng , Chen Ziyi , Li Hongyun , Hua Yinghui 
Published: November 2024

Background: Previous studies have revealed that early postoperative rehabilitation of chronic lateral ankle instability is just as crucial as surgical intervention. Immediate weightbearing has yielded good clinical results; however, randomized controlled studies have been limited. Purpose: To compare the clinical outcomes of patients with immediate weightbearing after lateral ankle ligament repair with those with delayed weightbearing after 2 weeks in a prospective randomized controlled study. Study Design: Randomized controlled clinical trial; Level of evidence, 1. Methods: Patients who underwent arthroscopic anterior talofibular ligament repair between August 2021 and December 2022 were randomized into 2 groups—immediate weightbearing with a hard ankle brace and nonweightbearing casting for 2 weeks followed by cast removal and weightbearing. Primary outcomes were the ankle function scores as assessed using the visual analog scale at rest and during activities, the American Orthopaedic Foot & Ankle Society (AOFAS) score, and the Karlsson Ankle Functional Score (Karlsson score). Secondary outcomes were the time to return to unsupported walking, jogging, work, and exercise and change in the ankle range of motion (ROM) at 3-, 6-, and 12-month follow-ups. Results: A total of 88 participants were included, consisting of 58 men and 30 women, with a mean age of 30.26 years. Computerized randomization resulted in 44 patients per group. These 2 groups displayed no difference in the AOFAS score, Karlsson score, and ankle ROM at all follow-ups. Patients who underwent immediate weightbearing had a significantly shorter time of returning to unsupported walking ( P < .001). No differences were observed in the time of returning to work, jogging, and sports exercise. Conclusion: For patients with chronic ankle instability after arthroscopic anterior talofibular ligament repair, immediate weightbearing allowed patients to return to unsupported walking more quickly and had no negative effects on the AOFAS score, Karlsson score, times of returning to normal life, jogging, sports exercise, and ankle ROM at 3-, 6-, and 12-month follow-ups compared with cast fixation. Registration: ChiCTR2100049612 (Chinese Clinical Trial Registry; https://www.chictr.org.cn/ ).
Removal of sequencing adapter contamination improves microbial genome databases
Authors: Moeller Andrew H. , Dillard Brian A. , Goldman Samantha L. , Real Madalena V. F. , Sprockett Daniel D. 
Published: November 2024

AbstractAdvances in assembling microbial genomes have led to growth of reference genome databases, which have been transformative for applied and basic microbiome research. Here we show that published microbial genome databases from humans, mice, cows, pigs, fish, honeybees, and marine environments contain significant sequencing-adapter contamination that systematically reduces assembly accuracy and contiguousness. By removing the adapter-contaminated ends of contiguous sequences and reassembling MGnify reference genomes, we improve the quality of assemblies in these databases.
Associations between various anthropometric indices and hypertension and hyperlipidaemia: a cross-sectional study in China
Authors: Feng Chuyao , Lu Cihang , Chen Kang , Song Bo , Shan Zhongyan , Teng Weiping 
Published: November 2024

Abstract
Background
This study aims to explore the association and determine the distinguished potential of anthropometric adiposity indices in screening for hypertension and hyperlipidaemia in the Chinese population.

Methods
A recent nationwide cross-sectional study, called the Thyroid Disorders, Iodine State, and Diabetes Epidemiological Survey (TIDE 2015–2017), provided the newest data on the relationships between anthropometric adiposity indices and hypertension and hyperlipidaemia and included 65,231 subjects. The area under the curve (AUC) was used to assess the feasibility of using these indices to distinguish hypertension and hyperlipidaemia. After age stratification, a restricted cubic spline (RCS) fitted for generalized linear regression was used to visualize the relationships of the body mass index (BMI), waist circumference (WC), the waist-to-height ratio (WHtR), the body roundness index (BRI), and the “a body shape index” (ABSI) with hypertension and hyperlipidaemia.

Results
The results showed that there were significant differences in the BMI, WC, the WHtR, the BRI, and the ABSI among the different age groups (P < 0.0001). After adjusting for sex, age, education, income, smoking status, urban or rural residence, and ethnicity in model, The WHtR and BRI had greater discriminatory power in identifying hypertension (AUC = 0.665, 95% confidence interval (CI) 0.660–0.671 for both), hypercholesterolaemia (AUC = 0.629, 95% CI 0.624–0.634 for both), and high low-density lipoprotein cholesterol (LDL-C; AUC = 0.659, 95% CI 0.653–0.664 for both) status in the overall population. When distinguishing hypertriglyceridaemia among the general population, the BMI (AUC = 0.711, 95% CI 0.706–0.716) and WC (AUC = 0.715, 95% CI 0.710–0.720) had greater discriminatory ability than the other anthropometric indices did. The BMI (AUC = 0.631, 95% CI 0.625–0.637) had the highest power for low high-density lipoprotein cholesterol (HDL-C) status in the general population.

Conclusions
Several anthropometric indices show significant correlation with hypertension and hyperlipidaemia. The WHtR and BRI were better in distinguishing hypertension, hypercholesterolaemia and high LDL-C status, while the BMI was better in hypertriglyceridaemia and low HDL-C status. The use of combined indices, such as the BMI, WC, the WHtR and the BRI, can be included in an individual’s medical history and can be used as tools for cardiovascular health screening, which may yield superior results for public health.
Shared and unique patterns of autonomous human endogenous retrovirus loci transcriptomes in CD14 + monocytes from individuals with physical trauma or infection with COVID-19
Authors: Koo Hyunmin , Morrow Casey D. 
Published: November 2024

AbstractSince previous studies have suggested that the RNAs of human endogenous retrovirus (HERV) might be involved in regulating innate immunity, it is important to investigate the HERV transcriptome patterns in innate immune cell types such as CD14 + monocytes. Using single cell RNA-seq datasets from resting or stimulated PBMCs mapped to 3,220 known discrete autonomous proviral HERV loci, we found individual-specific variation in HERV transcriptomes between HERV loci in CD14 + monocytes. Analysis of paired datasets from the same individual that were cultured in vitro with LPS or without (i.e. control) revealed 36 HERV loci in CD14 + monocytes that were detected only after activation. To extend our analysis to in vivo activated CD14 + monocytes, we used two scRNA-seq datasets from studies that had demonstrated activation of circulating CD14 + monocytes in patients with physical trauma or patients hospitalized with COVID-19 infections. For direct comparison between the trauma and COVID-19 datasets, we first analyzed 1.625 billion sequence reads from a composite pangenome control of 21 normal individuals. Comparison of the sequence read depth of HERV loci in the trauma or COVID-19 samples to the pangenome control revealed that 39 loci in the COVID-19 and 11 HERV loci in the trauma samples were significantly different (Mann-Whitney U test), with 9 HERV loci shared between the COVID-19 and trauma datasets. The capacity to compare HERV loci transcriptome patterns in innate immune cells, like CD14 + monocytes, across different pathological conditions will lead to greater understanding of the physiological role of HERV expression in health and disease.
Phlebotomine sand fly survey, blood meal source identification, and description of Sergentomyia imihra n. sp. in the central Sahara of Algeria
Authors: Benallal Kamal Eddine , Mefissel Mohammed , Dib Yassine , Depaquit Jérôme , Kavan Daniel , Harrat Zoubir , Dvořák Vít , Volf Petr , Halada Petr 
Published: November 2024

Abstract
Background
Phlebotomine sand flies (Diptera: Psychodidae) are important vectors of various pathogens, mainly Leishmania parasites. In the Old World, the most important genus in term of pathogens transmission is the genus Phlebotomus, which includes many proven or suspected vectors of several Leishmania species, while the genus Sergentomyia remains so far unproven as a vector of human pathogens. Algeria is one of the most affected countries by human leishmaniasis.

Methods
In the present study, an entomological survey was carried out in two provinces, Ghardaïa and Illizi, located in the north and central Sahara, respectively, where cases of human leishmaniasis are recorded. Our goal was to understand the role of the local sand fly species in the transmission of Leishmania parasites and to analyze their blood meal preferences. Collected sand flies were identified by a combination of morphological and molecular approaches that included DNA-barcoding and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) protein profiling. In addition, female blood meals were analyzed by peptide mass mapping using MALDI-TOF MS.

Results
In total, 640 sand fly specimens belonging to Phlebotomus and Sergentomyia genera were collected in the two provinces. Sergentomyia antennata and Se. fallax were most abundant species in Ghardaïa, and Ph. papatasi and Ph. alexandri in Illizi. In addition, a new sand fly species was described in Illizi named Sergentomyia (Sergentomyia) imihra n. sp. Blood meal analysis of the engorged females revealed various mammalian hosts, especially goats, but also humans for Phlebotomus papatasi and Ph. alexandri, suggesting that these vector species are opportunistic feeders.

Conclusions
Integrative approach that combined morphological analysis, sequencing of DNA markers, and protein profiling enabled the recognition and description of a new Sergentomyia species, raising the number of the Algerian sand fly fauna to 27 species. Further sand fly surveillance in the central Sahara is recommended to identify the thus-far unknown males of Se. imihra n. sp.

Graphical Abstract