bluuebunny/crossref_metadata_2025_split huggingface dataset:
GROWTH THEORY AS AN UNWANTED CHILD OF MACRO-DYNAMICS
Authors: Punzo Lionello F. 
Published: January 2019

<p align="center"><strong>ABSTRACT</strong></p><p class="NormaleWeb1">The story this paper tells, attempts to explain 1) how Neo-Classical growth theory happened to be simultaneously born by the hands of Solow (1956) and Swan (1956); and 2) how it carried its signature characteristics, <em>i.e.</em> the exogeneity of the long run growth driver. Both issues are ascribed to the heritage of unsolved problems from Macroeconomics, in its most mature version a non-linear theory of fluctuations.<strong></strong></p><p><strong> </strong></p><p align="center">LA TEORÍA DEL CRECIMIENTO COMO UN VÁSTAGO NO DESEADO DE LA MACRODINÁMICA</p><p align="center"><strong>RESUMEN</strong></p><p class="NormaleWeb1">Este artículo narra e intenta explicar: 1) cómo la teoría neoclásica del crecimiento surgió de forma simultánea de las manos de Solow (1956) y de Swan (1956) y 2) cómo llevó consigo sus características distintivas, <em>i.e.</em>, la exogeneidad de su fuerza motriz de largo plazo. Ambas cuestiones se atribuyen a la herencia de problemas no resueltos de la macroeconomía en su versión más madura, una teoría no lineal de las fluctuaciones cíclicas.</p>
ARISTÓTELES Y NIETZSCHE: LA ÉTICA EN EL TRABAJO ACADÉMICO Y CIENTÍFICO
Authors: Loría Eduardo 
Published: January 2019

<p>Por lo menos desde hace veinte años viene creciendo de manera alarmante<em> </em>la exigencia por parte de instituciones y revistas académicas de alta reputación (reconocidas en <em>listas blancas</em>) para garantizar prácticas éticas en la publicación científica. Esto se acompaña de la exigencia de gobiernos, universidades e instituciones de todo el mundo por aumentar la producción del conocimiento en todas las áreas del saber. Lo anterior parece responder al hecho de que los académicos deben justificar ante la sociedad —en forma de productos finales de investigación— su trabajo cotidiano y, más aún, los ingresos y financiamientos que reciben de los contribuyentes. Es decir, la sociedad, representada por esos organismos, les exige a los académicos que demuestren de manera concreta la utilidad científica y social de su trabajo. De este modo se han creado índices de productividad y de competitividad y recompensas económicas a instituciones y académicos...</p>
INDUSTRY, COMPETITIVENESS, EXTERNAL TRADE AND GROWTH ACCELERATION
Authors: Costa da Silva Guilherme Jonas , Do Carmo Hermida Camila 
Published: January 2019

<p align="center"><strong>ABSTRACT</strong><strong></strong></p><p>This paper presents a pioneering theoretical model for the acceleration of economic growth, from the junction of elements of the post-Keynesian theory of long run growth with Neo-Schumpeterian aspects. Some new findings were pointed, since it shows that the growth acceleration of a given country depends primarily on its international competitiveness, which is given for the capacity for imitation and technological innovation, beyond growth of physical production capacity of the economy and growth acceleration of world income.</p><p align="center"> </p><p align="center">INDUSTRIA, COMPETITIVIDAD, COMERCIO EXTERIOR Y ACELERACIÓN DEL CRECIMIENTO</p><p align="center"><strong>RESUMEN</strong><strong></strong></p>Este artículo presenta un modelo teórico pionero para la aceleración del crecimiento económico mediante la unión de elementos de la teoría poskeynesiana del crecimiento a largo plazo con aspectos neoeschumpeterianos. Se señalaron algunos hallazgos nuevos, ya que muestra que la aceleración del crecimiento de un país depende principalmente de su competitividad internacional, que se expresa por la capacidad de imitación e innovación tecnológica, más allá del crecimiento de la capacidad de producción física de la economía y de la aceleración del crecimiento del ingreso mundial.
Development and In-vitro characterization of floating drug delivery system of ketoconazole
Authors: Rathi Jagdish , Bhowmick Mithun , Sharma Rahul , Panse Sagar , Pandit Rupal , Gupta Sachin 
Published: January 2019

The oral route is increasingly being used for the delivery of therapeutic agents because the low cost of the therapy and ease of administration lead to high level of patient compliances. Floating drug delivery system (FDDS) float in the gastric fluid and prolong GRT to obtain sufficient drug bioavailability, because of their lower bulk density compared to that of the aqueous medium. The aim of the present study is to prepare floating tablets as a delivery system for controlled release of Ketoconazole. Ketoconazole is a drug of choice in antifungal category and gives significant result. Floating tablets containing Ketoconazole were prepared by direct compression technique using varying concentrations of different grades of polymers of Hydrxy Propyl Cellulose & Xanthan gum. To evaluate the prepared floating tablets for various parameters like hardness, friability, uniformity of drug content, in-vitro floating studies, in-vitro dissolution studies.
Keywords: Ketoconazole, Floating drug delivery system, Hydrxy Propyl Cellulose, Xanthan gum
Design, formulation and evaluation of sustained release bilayer tablets of ciprofloxacin hydrochloride
Authors: Kar Ayan Kumar , Majumder Tandrima , Majumdar Subhabrota , Mahanti Beduin , Kar Banhishikha , Chakraborty Satyam , Parya Hiranmoy , Saha Surajit 
Published: January 2019

The present research work involve the development of a bilayer tablet of ciprofloxacin hydrochloride using a superdisintegranting agent (sodium starch glycolate) for the fast releasing layer and hydrophobic polymers like ethyl cellulose, acrycoat L100 and acrycoat S100 for the delayed releasing layer. Ciprofloxacin was used as a model drug. Tablets were prepared by wet granulation method. The prepared bilayer tablets were evaluated for angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio at the precompression stage and thickness variation, weight variation, hardness, friability, drug content, disintegration time, in vitro drug release study at the post compression stage.. In vitro dissolution studies were carried out in a USP 24 apparatus I. In vitro dissolution kinetics followed the Higuchi model via a non-Fickian diffusion controlled release mechanism after the initial burst release. FT-IR studies revealed that there was no interaction between the drug and polymers. Statistical analysis (ANOVA) showed no significant difference in the cumulative amount of drug release after 15 min, but significant difference (p < 0.05) in the amount of drug released after 12 h from optimized formulations was observed. Present research work involves the development of a bilayer tablet of ciprofloxacin hydrochloride using a superdisintegrant for the fast releasing layer and hydrophobic polymers for the delayed releasing layer. There was the initial burst effect from the formulations to provide the loading dose of the drug, followed by sustained release to provide maintenance dose of the drug.
Keywords: Superdisintegrants, Burst release, Wet granulation, non-Fickian, Sustained release
Transdermal patches fabricated from hyaluronic acid for the enhanced skin penetration of therapeutic entities
Authors: Nair Syam S. 
Published: January 2019

Skin is an attractive route for drug delivery. However poor permeation of drugs across the skin due to the presence of extremely ordered architecture of outermost layer of skin, led to several investigation to improve the permeability of drugs. Polysaccharides remain widely studied biomaterial for the sustained delivery of drug molecules across the skin. The advance of hyaluronic acid (HA) chemistry with multiple benefits has improved the attention of research groups for its application in the skin transportation of drug molecules. Beginning from the advantages of transdermal route, the present review details the application of HA in transdermal drug delivery. In the last few decades, substantial investigation in the domain has improved the requirement for an outline of all the developments, which is depicted in the review. The review also presented different types of HA based transdermal devices such as transferosomes, nanoemulsions, microneedle etc and their potential to improve the transdermal drug delivery. Furthermore the application of HA through chemical modification as a potential transdermal device is also presented.
Keywords: Hyaluronic acid, transdermal drug delivery, microneedles, nanoemulsion, hydrogel
Phytochemical screening and GC–MS analysis of bioactive compounds present in ethanolic leaves extract of Silybum marianum (L).
Authors: Padma M , Ganesan S , Jayaseelan T , Azhagumadhavan S , Sasikala P , Senthilkumar S , Mani P 
Published: January 2019

Objective: To investigate the phytochemicals and GC-MS analysis of ethanol extracts of Silybum marianum.
Methods: The air-dried leaves were powdered and subjected to selective sequential extraction using solvents of increasing polarity through percolation, ethanol to obtain an ethanolic extract. Then, each of the extracts was further subjected to gas chromatography-mass spectrometry.
Results: Qualitative determination of the different biologically active compounds from crude extracts of Silybum marianum using gas chromatography-mass spectrometry revealed different types of high and low molecular weight chemical entities with varying amounts present in each of the extracts. These chemical compounds are considered biologically and pharmacologically important.
Conclusions: The study established the chemical composition and anticancer activity of the plant.
Keywords: Silybum marianum, Phytochemicals screening, GC–MS analysis, Bioactive compounds.
Designing fabrication and evaluation of Oral fast Disintegrating tablet of Ranitidine HCL
Authors: Patel Afroza Akbar , Shaikh Siraj N , Patel Huzaifa , Band Afzal , Shaoor Ahmed 
Published: January 2019

The aim of this research work was to design develop & evaluate oral fast disintegrating tablets of Ranitidine HCL. The Orodispersible tablets of Ranitidine HCl were prepared by using direct Compression technique with a Synthetic Superdisintegrant such as Crosspovidone and a natural Superdisintegrant Fenugreek gum in different concentration. 32 factorial designs was applied to study the effect of independent variables, concentration of Crosspovidone & Fenugreek gum on dependent variables like Cumulative % Drug release and Disintegration time by using design expert software. Prepared oral fast disintegrating tablets evaluated for Pre and Post-compression parameters. The prepared tablets exhibited satisfactory physico-chemical characterise especially fast disintegration & dissolution property. Full factorial design and optimization technique successfully used in the development oral fast disintegrating tablets. Comparing the all the formulations, formulation F9 was considered as optimized formulation which shows excellent fast disintegration, in vitro dissolution, and faster drug release within 6 min in comparison to other batches also stable in stability study.
Keywords: Fast disintegrating, Ranitidine, Crosspovidone, Gum, Optimizations, Water absorption ratio
Phytopharmacology of Chloroxylon swietenia: a review
Authors: Charanraj Nallagiri , Venkateswararao Pragada , Vasudha Bakshi , Narender Boggula 
Published: January 2019

The nature has provided a complete store house of remedies to use for all ailments for mankind. The knowledge on drugs has accumulated over thousands of years as a result of mans inquisitive nature. Phytomedicines or natural prescriptions, have assumed a basic part in World wellbeing for a large number of years. As per the World Health Organization (WHO), "natural medications incorporate herbs, home grown materials, home grown arrangements and completed home grown items, that contain as dynamic fixings parts of plants, or other plant materials, or blends. Chloroxylon swietenia DC. (Family: Rutaceae) is an important traditional medicinal plant used in the treatment of various ailments like fungal infection of skin, rheumatism, common cold, cough, ophthalmic infection and cataract, wounds and as an astringent. It is a tropical aromatic tree of dry deciduous forests popularly known as East Indian Satin Wood. The findings of this study will facilitate pharmacognostic standardization of the plant material and aid in the preparation of an herbal monograph for the species. Further studies on this plant must be carried out to explore some other important, necessary and unknown benefits. As the plant has multifunctional properties, this review is worthwhile and therefore it presents comprehensive analysed information on the phytochemical and pharmacological aspects of the botanical.
Keywords: Chloroxylon swietenia, phytomedicines, pharmacological aspects, anti-feedant, anti-bacterial activity, IUCN, vulnerable species.
Phytochemical analysis, antioxidant, antidiabetic and anti-inflammatory activity of bark of Gardenia latifolia
Authors: Ansari Farheen , Khare Salaj , Dubey B. K. , Joshi Amit , Jain Amit , Dhakad Suresh 
Published: January 2019

Gardenia latifolia (Rubiaceae) is commonly known as Indian boxwood or Ceylon boxwood, is a densely foliaceous small tree that occurs throughout the greater parts of Indian common in deciduous forests along the streams. The stem bark and fruits are reported to be used in the treatment of various ailments such as snake bite, skin diseases, stomach pains, caries in humans and ephemeral fever in live stocks. Many beneficial medicinal products are used to treat various serious diseases and disorders like diabetes, cancer and cardiovascular diseases without side effects. Hence our study focused to investigate the phytochemical analysis, quantification of bioactive compounds, in vitro free radical scavenging activity (DPPH radical method), anti-inflammatory activity (Carrageenan induced hind paw oedema ), in vitro anti-diabetic activity by enzyme inhibition activity of bark of Gardenia latifolia (hydroalcoholic extract) which has boundless medicinal properties. The results of this study showed the evidence that the extracts when tested for their phytochemicals and free radical scavenging activity were found to have considerable antioxidant potential. This plant also exhibit better in vitro enzyme inhibitory activity and anti-inflammatory activity. The results of this study indicate that the hydroalcoholic extract of Gardenia latifolia bark has significant pharmacological properties.
Keywords: Gardenia latifolia, Phytochemical analysis, DPPH radical method, Anti-inflammatory activity, Anti-diabetic activity
Bioactive potential analysis of brown seaweed Sargassum wightii using UV-VIS and FT-IR
Authors: Rajeswari R. , Jeyaprakash K. 
Published: January 2019

The current study was investigated to explore the biogenic molecules of Sargassum wightii collected from the south east of Tamil Nadu, India. The biogenic molecules extracted from Sargassum wightii by using methanol as a solvent and the analysis was carried out by using UV-Visible spectroscopy and FT-IR. The UV-Visible spectrum of the methanolic extract of Sargassum wightii exposed the existence of the biogenic molecules separated from 200 - 1100 nm among the absorption. The incidence of peaks from 234-676 nm discovered the presence of flavonoids and its derivatives. The unprocessed methanolic extract of Sargassum wightii was travelled in to FT-IR and it indicated the being of phenols and flavonoids their functional groups such as alcohol, alkane, carboxylic acids, esters, ethers, alkynes and aromatics. From the results, the future aim of this study is necessary to develop the target site to treat dreadful diseases.
Keywords: Sargassum Wightii, FT-IR, UV-Visible Spectroscopy, Phytochemical analysis.
Permanganatic oxidation of neomycine sulphate salt in basic media: a kinetic study
Authors: Lawale Narayan V. , Dobhal Bhagwan Singh , Gaur Sandip Singh , Pardeshi Rajendra 
Published: January 2019

Permanganatic oxidation of Neomycine sulphate salt has been studied at different temperatures using spectrophotometer under alkaline conditions. The effect of variation of substrate Neomycine sulphate salt (NS), oxidant (KMnO4) and NaOH was studied under pseudo first order reaction conditions. The effect of different salts and solvents on oxidation of NS was also studied. The reaction was found to be first order with respect to oxidant, substrate and NaOH..
Keywords: Neomycine sulphate salt (NS), KMnO4 , permanganatic oxidation, alkaline permanganate
HPTLC fingerprinting of stem bark extract of Nyctanthes arbor-tristis (L.)
Authors: Ananthi T. , Vijayalakshmi S. 
Published: January 2019

Fingerprint profile of bark extract of Nyctanthes arbor-tristis using High Performance Thin Layer chromatography (HPTLC) has been established. HPTLC is a valuable tool for the investigation of medicinal plants with reference to the qualitative analysis of the phytoconstituents. Separation of the active constituents from the extracts has been developed using solvent system of Toluene: Ethyl acetate: Formic acid (5:4:1). The HPTLC analysis showed the presence of the flavonoid quercetin in the standard as well as in the sample and the Rf value was 0.73. These images of fingerprinting help in the proper identification and quantification of the marker compounds. On the basis of the marker compounds, new drugs could be formulated to treat various diseases
Keywords: Nyctanthes arbor- tristis, HPTLC analysis, quercetin, bark extract
Simultaneous estimation of gabapentin and methylcobalamin in bulk and pharmaceutical dosage form by RP-HPLC
Authors: Bakshi Anjali , Monika K , Bhutada Shweta , Bhagvan Raju M. 
Published: January 2019

A simple, selective, linear, precise, and accurate RP-HPLC method was developed and validated for the simultaneous estimation of Gabapentin & Methylcobalamin from bulk and formulation. Chromatographic separation was achieved Isocratically on an Inertsil C18 column (150x4.6, 5µ particle size) using a mobile phase Buffer: Acetonitrile in the ratio of 60:40 v/v. The flow rate was 1.0 ml/min, effluents were detected at 264 nm and 10µl of sample was injected. Retention time of Gabapentin & Methylcobalamin was found to be 2.7 and 4.13 min respectively. Linearity of the method was in the concentration range of 25-150 µg for Gabapentin & 0.125-0.750 µg for Methylcobalamin. Percent recoveries obtained for both the drugs were 100.00%. The percentage RSD for precision of the method was found to be less than 2%. The method was validated according to the ICH guidelines. The method developed was successfully applied for the analysis of simultaneous estimation of Gabapentin & Methylcobalamin tablets and was fairly good in comparison with other methods.
Keywords: Gabapentin, Methylcobalamin, HPLC.
Muco-constriction: A ray of promise from medicinal plants
Authors: Aruna V , Soundharya R , Amruthavalli GV , Gayathri R 
Published: January 2019

JRK’s Anti-coff was evaluated for blood purification benefit by phagocytosis. and surprisingly we found that Aniscochilus carnosus showed muco-constriction benefit, while Ocimum sanctum and Adathoda vasica showed mucolytic property. The clinical implication of the above therapeutic benefits is discussed in detail in the article from the context of Siddha system of medicine. The findings are discussed in the article.
Keywords: Mucolytic, Anti-coff, Cough, N-acetyl cysteine, Xylometazoline
Pattern of analgesic use in hospitalized children at a pediatric general ward in a tertiary care teaching hospital
Authors: Puja Dr. , Dhasmana D.C. , Kohli Saurabh , Chander Vipin 
Published: January 2019

Background: analgesic use is common in adults but their use in children has not been extensively studied. This observational study was envisaged to study prevalence and pattern of analgesic use in hospitalized children in pediatric general ward.
Methods: 120 patients were included in the study. Disease was classified as per ICD-10 and medicines used were classified according to ATC classification. WHO indicators for rationality was used. Descriptive statistics was used to present the data i.e. percentage; proportions, frequency, mean and standard deviation using Microsoft excel worksheet.
Result: A total of 791 drugs from different classes were prescribed to 120 patients with a mean of 6.6 + 2.68 drugs described per patient during their stay in the hospital. 81 analgesics were prescribed. 25 were prescribed as fixed dose combination. Paracetamol was the most commonly prescribed non steroidal anti-inflammatory agent.
Keywords: analgesics, children, fixed dose combinations
A comprehensive review on ethnobotanical applications and pharmacological activities of Acampe praemorsa (Roxb.) Blatt. & McCann (Orchidaceae)
Authors: Vibha S , Hebbar Sushmitha S , Mahalakshmi S.N. , Prashith Kekuda T.R. 
Published: January 2019

Orchidaceae is one of the two largest families in angiosperms. Orchids are popular owing to the most beautiful flowers they produce and due to their wide spread ethnobotanical importance. In this review, ethnobotanical uses and pharmacological activities of A. praemorsa is discussed by referring flora, journals, and search engines such as Google scholar, ScienceDirect and Pubmed. Ethnobotanical investigations have revealed the potential therapeutic roles of different parts of A. praemorsa. The orchid is used traditionally by for treating ailments such as stomachache, earache, backache, wounds, neuralgia, rheumatism, eye diseases, sciatica, cough and fracture. A. praemorsa is investigated for various pharmacological activities. Studies have revealed the potential of A. praemorsa to exhibit a range of bioactivities such as anticancer, antibacterial, antifungal, antioxidant and anti-inflammatory activities. In conclusion, A. praemorsa is an extensively used epiphytic orchid for medicinal purposes in several parts of the India and other countries. Major emphasis has to be given in order to conserve this medicinally important orchid species. A. praemorsa can be a promising candidate in terms of its pharmacological potential.
Keywords: Orchids, Orchidaceae, Acampe praemorsa, Ethnobotanical, Pharmacological
In-vitro Antioxidant Activity and Antimicrobial Activity of Hydroalcoholic Extracts of Vernonia cinerea
Authors: Mehta Jaswinder , Joshi Peenu Mahendra , Kushwaha Priyanka , Parkhe Geeta 
Published: January 2019

The aim of present study was to estimate the in vitro antioxidant potential and antimicrobial activity of hydroalcoholic extract of Vernonia cinerea. Antioxidant activity was assessed by using 2, 2- diphenyl-1-picryl-hydrazyl (DPPH) assay using ascorbic acid as standard antioxidant. The extract was found to scavenge effectively the free radicals. The total flavonoid contents were determined by established methods and were found to be 0.547 mg/100mg in quercitin equivalents. Antimicrobial activity was performed against 2 stains of human pathogenic bacteria by well diffusion method. Hydroalcoholic extract of Vernonia cinerea showed good antimicrobial activity against gram positive bacteria. The antioxidant activities may be attributed to the presence of significant amounts of flavonoid compounds. Results indicated that hydroalcoholic extract of Vernonia cinerea possess significant antioxidant effect in dose dependent manner, followed by the hydroalcoholic extract of Vernonia cinerea possessed good antimicrobial activity.
Keywords: Antioxidant activity, Radical scavenging activity, Free radicals, Antimicrobial activity.