bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advancing the field of communication research in pediatric oncology: A systematic review of the literature analyzing medical dialogue
Authors: Kaye Erica C. , Kiefer Ashley , Zalud Kristina , Gattas Melanie , Snyder Ian , Spraker‐Perlman Holly , Baker Justin N. 
Published: August 2018

AbstractHistorically, communication research in pediatric oncology has relied on surveys and interviews, resulting in cross‐sectional and retrospective studies constrained by selection, recognition, and recall biases. This systematic review identifies and synthesizes the published literature analyzing primary data from recorded conversations between pediatric oncologists, patients with cancer, and their families, with the following objectives: (1) to identify the extent and content of the evidence base, (2) to describe methodological strategies utilized in the analysis of recorded medical dialogue, (3) to aggregate salient findings, and (4) to generate recommendations for future prospective research related to analysis of medical dialogue in pediatric oncology.
Feasibility of systematic poverty screening in a pediatric oncology referral center
Authors: Zheng Daniel J. , Shyr Derek , Ma Clement , Muriel Anna C. , Wolfe Joanne , Bona Kira 
Published: August 2018

AbstractBackgroundBased on the strong link between poverty and child health outcomes, both the American Academy of Pediatrics (AAP) and national pediatric oncology associations have advocated for routine clinical poverty screening. Systematic implementation of this recommendation in pediatric oncology is not yet standard, and feasibility data are needed. We report the feasibility of routine poverty screening in a pediatric oncology referral center and baseline poverty characteristics of this population.MethodsFrom 2013 to 2017, 448 families with newly diagnosed pediatric cancer at Dana‐Farber/Boston Children's Cancer and Blood Disorders Center were offered the Psychosocial Assessment Tool 2.0 (PAT) as part of routine care. The PAT includes a two‐item screen for household material hardship (HMH). All families were asked about annual household income by a resource specialist. Data were abstracted with sociodemographic and child/disease characteristics. Descriptive statistics are reported.ResultsFour hundred and thirteen families completed the PAT (response rate 92%), of whom 394 (95%) completed specific questions assessing for HMH. Ninety‐four percent of families who met with a resource specialist disclosed their annual household income. One quarter (27%) of families was ≤200% federal poverty level at diagnosis, and 44% of families endorsed at least one domain of HMH. The most frequent domains of HMH included housing (24%), utilities (20%), and transportation (20%).ConclusionsSystematic poverty screening per AAP and pediatric oncology psychosocial standards of care is feasible in routine cancer care. There is a high baseline incidence (44%) of HMH in at least one domain in families with newly diagnosed pediatric cancer who may benefit from early identification and resource intervention.
Cover Image, Volume 67, Issue 9
Authors: Arrospide Eneko , Durana Gaizka , Azkune Mikel , Aldabaldetreku Gotzon , Bikandi Iñaki , Ruiz‐Rubio Leire , Zubia Joseba 
Published: August 2018

The cover image, by Eneko Arrospide et al., is based on the Review Polymers beyond standard optical fibres ‐ fabrication of microstructured polymer optical fibres, DOI: 10.1002/pi.5602.
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Asymmetric synthesis of tetrahydroquinoline‐type ecdysone agonists and QSAR for their binding affinity against Aedes albopictus ecdysone receptors
Authors: Yokoi Taiyo , Nakagawa Yoshiaki , Miyagawa Hisashi 
Published: August 2018

AbstractBACKGROUNDTetrahydroquinolines (THQs) are a class of non‐steroidal ecdysone agonists that specifically bind to mosquito ecdysone receptors (EcR). The THQ scaffold contains two chiral centers at the C‐2 and C‐4 positions, resulting in four stereoisomers. We have previously shown that the (2R,4S)‐isomers are the most biologically active; however, the lack of a practical synthetic method for these isomers has hampered further structure–activity studies.RESULTSIn this study, a chiral phosphoric acid‐catalyzed Povarov reaction was employed to develop a facile asymmetric synthesis of THQs with a (2R,4S)‐configuration, which allowed the preparation of a 40‐compound library of enantiopure THQs. Evaluation of their binding affinity against Aedes albopictus EcR, followed by quantitative structure–activity relationship (QSAR) analyses, uncovered the physicochemical properties of THQs that are important for the ligand–receptor interaction. The most potent THQ derivative was twofold more active than the molting hormone, 20‐hydroxyecdysone.CONCLUSIONThe QSAR results provide valuable information for the rational design of novel mosquito‐specific ecdysone agonists. © 2018 Society of Chemical Industry
Molecular epidemiology and phylogenetics of human enteroviruses: Is there a forest behind the trees?
Authors: Lukashev Alexander N. , Vakulenko Yulia A. , Turbabina Natalia A. , Deviatkin Andrei A. , Drexler Jan Felix 
Published: August 2018

SummaryEnteroviruses are among the best studied small non‐enveloped enteric RNA viruses. Most enteroviruses are easy to isolate in cell culture, and many non‐polio enterovirus strains were archived worldwide as a byproduct of the WHO poliovirus surveillance system. Common outbreaks and epidemics, most prominently the epidemic of hand‐foot‐and‐mouth disease with severe neurological complications in East and South‐East Asia, justify practical interest of non‐polio enteroviruses. As a result, there are over 50 000 enterovirus nucleotide sequences available in GenBank. Technical possibilities have been also improving, as Bayesian phylogenetic methods with an integrated molecular clock were introduced a decade ago and provided unprecedented opportunities for phylogenetic analysis. As a result, hundreds of papers were published on the molecular epidemiology of enteroviruses. This review covers the modern methodology, structure, and biases of the sequence dataset available in GenBank. The relevance of the subtype classification, findings of co‐circulation of multiple genetic variants, previously unappreciated complexity of viral populations, and global evolutionary patterns are addressed. The most relevant conclusions and prospects for further studies on outbreak emergence mechanisms are discussed.
Clinical Cellular Therapeutics Accelerate Clot Formation
Authors: George Mitchell J. , Prabhakara Karthik , Toledano-Furman Naama E. , Wang Yao-Wei , Gill Brijesh S. , Wade Charles E. , Olson Scott D. , Cox Charles S. 
Published: August 2018

Abstract
Clinical cellular therapeutics (CCTs) have shown preliminary efficacy in reducing inflammation after trauma, preserving cardiac function after myocardial infarction, and improving functional recovery after stroke. However, most clinically available cell lines express tissue factor (TF) which stimulates coagulation. We sought to define the degree of procoagulant activity of CCTs as related to TF expression. CCT samples from bone marrow, adipose, amniotic fluid, umbilical cord, multi-potent adult progenitor cell donors, and bone marrow mononuclear cells were tested. TF expression and phenotype were quantified using flow cytometry. Procoagulant activity of the CCTs was measured in vitro with thromboelastography and calibrated thrombogram. Fluorescence-activated cell sorting (FACS) separated samples into high- and low-TF expressing populations to isolate the contribution of TF to coagulation. A TF neutralizing antibody was incubated with samples to demonstrate loss of procoagulant function. All CCTs tested expressed procoagulant activity that correlated with expression of tissue factor. Time to clot and thrombin formation decreased with increasing TF expression. High-TF expressing cells decreased clotting time more than low-TF expressing cells when isolated from a single donor using FACS. A TF neutralizing antibody restored clotting time to control values in some, but not all, CCT samples. CCTs demonstrate wide variability in procoagulant activity related to TF expression. Time to clot and thrombin formation decreases as TF load increases and this procoagulant effect is neutralized by a TF blocking antibody. Clinical trials using CCTs are in progress and TF expression may emerge as a safety release criterion.
Noninvasive Diagnosis and Molecular Phenotyping of Breast Cancer through Microbead‐Assisted Flow Cytometry Detection of Tumor‐Derived Extracellular Vesicles
Authors: Li Wenzhe , Shao Bin , Liu Changliang , Wang Huayi , Zheng Wangshu , Kong Weiyao , Liu Xiaoran , Xu Guobin , Wang Chen , Li Huiping , Zhu Ling , Yang Yanlian 
Published: August 2018

AbstractBlood‐based detection and molecular phenotyping are highly desired for the early diagnosis and dynamic monitoring of cancer. Extracellular vesicles (EVs) carry molecular information from the cells of origin and are biomarkers of cancer. However, the detection and molecular analysis of EVs has been challenging due to their nanoscaled size. Here, an assessment of the detection and molecular phenotyping of serum EVs based on microbead‐assisted flow cytometry is established. The clinical utility of this method is validated in the diagnosis and human epidermal growth factor receptor 2 (HER2) phenotyping of breast cancer. Good correlation between the status of epithelial cell adhesion molecule (EpCAM) and HER2 expression in EVs and in the cells of origin is found. Both EpCAM+ and HER2+ EVs are demonstrated to be effective diagnostic markers of breast cancer with high sensitivity and specificity. EV‐based HER2 phenotyping is consistent with tissue‐based HER2 phenotyping by immunohistochemistry and can be used as a surrogate for the invasive tissue assessments. The microbead‐assisted flow cytometry assessment of EVs enables rapid and noninvasive detection and molecular phenotyping of cancer and would help to personalized treatment and cancer survival.
Enhanced Process Integration and Device Performance of Carbon Nanotubes via Flocculation
Authors: Gao Theodore Z. , Lei Ting , Molina‐Lopez Francisco , Bao Zhenan 
Published: August 2018

AbstractPolymer sorting is a promising strategy for purifying semiconducting carbon nanotubes (CNTs), offering high selectivity and yield, in addition to low cost and scalability. However, sorting conditions that maximize the yield lead to CNT dispersions with significant amounts of excess sorting polymer. This has undesirable implications for CNT device performance, such as decreased charge carrier mobility and on–off ratio. Here, a method for removing excess sorting polymer based on flocculation is demonstrated. This approach is broadly applicable to various sorting polymers and facilitates recycling of the sorting polymer. In addition, devices made with flocculated CNTs exhibit improved performance and require minimal post‐processing steps. Flocculation was found to be particularly effective for inkjet‐printed CNT transistors on SiO2, producing devices with mobilities ≈10 cm2 V‐1 s‐1 and on–off ratios ≈106. These results show that flocculation is a facile approach to improving the process integration and device performance of polymer‐sorted CNTs.
Enough is enough: the UK Prevent Strategy and normative invalidation
Authors: Bentley Michelle 
Published: August 2018

AbstractThe clash between national security and civil rights comprises one of the most controversial aspects of counter-radicalisation strategy. Analysts present this as a conflict between the need for restrictive security measures (for example, surveillance) and the need to uphold civil liberties (for example, privacy and freedom of speech). In responding to this dilemma, the article examines how this binary normative struggle impacts on the rhetorical presentation of counter-radicalisation policies – in particular, the UK Prevent Strategy and the rhetoric employed by UK Prime Minister and former Home Secretary, Theresa May. It argues that the normative environment has obliged May to construct rhetoric within the context of, what is termed here, normative invalidation. In facing two comparably compelling and related norms of action, May is necessarily required to invalidate or neutralise any norm not adhered to as an essential characteristic of rhetorical strategy. This is discussed in relation to the Strategic Narratives paradigm.
Droplets in isotropic turbulence: deformation and breakup statistics
Authors: Ray Samriddhi Sankar , Vincenzi Dario 
Published: August 2018

The statistics of the deformation and breakup of neutrally buoyant sub-Kolmogorov ellipsoidal drops is investigated via Lagrangian simulations of homogeneous isotropic turbulence. The mean lifetime of a drop is also studied as a function of the initial drop size and the capillary number. A vector model of a drop previously introduced by Olbricht et al. (J. Non-Newtonian Fluid Mech., vol. 10, 1982, pp. 291–318) is used to predict the behaviour of the above quantities analytically.
Payments for environmental services to strengthen ecosystem connectivity in an agricultural landscape
Authors: Bateman Laura , Yi Dale , Cacho Oscar J , Stringer Randy 
Published: August 2018

AbstractThis article investigates the use of payments for environmental services to support a wildlife corridor between two Priority Tiger Conservation Landscapes in central Sumatra, Indonesia. Several hundred smallholders operate within a Protection Forest linking the Tiger Conservation Landscapes. This study explores the willingness of these smallholders to accept a payment requiring them to forgo access to their land for five years. In addition to asking households directly what they would be willing to accept (WTA), we also ask them to infer what their neighbour would accept. The study finds evidence of hypothetical bias in the conventional WTA values, with a statistically significant difference between what people say they would be willing to accept when surveyed, compared to what they say would actually be willing to accept in a ‘real life’ situation. We show how inferred valuation techniques can mitigate against this.
Mega (metal-poor) not so much : Non-LTE spectroscopic stellar parameters and abundance determination of Ultra metal-poor stars
Authors: Ezzeddine Rana , Sitnova Tatyana , Frebel Anna , Mashonkina Lyudmilla , Plez Bertrand 
Published: August 2018

AbstractWe present Non-Local Thermodynamic Equilibrium (Non-LTE) abundance corrections for Mg, Ca, and Fe in 12 ultra metal-poor (UMP) stars ([Fe/H] &lt; −4.00). We show that they increase in absolute value toward the lower metallicity up to 0.45 dex for Mg, 0.30 dex for Ca, and 1.00 dex for Fe. This represents a first step toward a full Non-LTE analysis of chemical species in the UMP stars that will enable us to put useful constraints on the properties of the “First” stars.
The age-metallicity relation from a sample of white dwarf-main sequence binaries
Authors: Rebassa-Mansergas A. , Anguiano B. , García-Berro E. , Freeman K. C. 
Published: August 2018

AbstractThe age-metallicity relation (AMR) is a fundamental observational constraint for understanding how the Galactic disc formed and evolved chemically in time. However, there is not yet an agreement on the observational properties of the AMR, primarily due to the difficulty in obtaining accurate ages for individual field stars. We have started an observational campaign for providing new observational input by using wide white dwarf-main sequence (WDMS) binaries. WDs are natural clocks and can be used to derive accurate ages. Metallicities can be obtained from the MS companions. Since the progenitors of WDs and the MS stars were born at the same time, WDMS provide a unique opportunity to constrain in a robust way the properties of the AMR. We present the AMR derived from analysing a pilot sample of 23 WDMS and provide clear evidence for the lack of correlation between age and metallicity at young and intermediate ages.
YaPSI: a new database of evolutionary tracks and isochrones
Authors: Spada F. , Demarque P. , Kim Y. -C. , Boyajian T. S. , Brewer J. M. 
Published: August 2018

AbstractThe Yale–Potsdam Stellar Isochrones (YaPSI) cover the low and intermediate stellar mass regime (0.15 to 5.0 M⊙) for a wide range of solar-scaled chemical compositions (metallicity from −0.5 to +0.3; helium mass fraction from 0.25 to 0.37, assigned independently of each other). The tracks are finely spaced in mass, to allow for accurate interpolation. The models feature state-of-the-art input physics relevant to low-mass stars modeling (surface boundary conditions, equation of state), thus updating the faint end of the Yonsei-Yale (YY) isochrones. Utility codes, such as an isochrone interpolator in age, metallicity and helium content, are also provided. The YaPSI isochrones are in good agreement with the empirical mass–luminosity and mass–radius relations available to date, and provide satisfactory fitting of the color-magnitude diagrams of well-studied open clusters.
The vertical metallicity gradients of mono-age stellar populations in the Milky Way thin disk
Authors: Ciucă Ioana , Kawata Daisuke , Lin Jane , Casagrande Luca , Seabroke George , Cropper Mark 
Published: August 2018

AbstractWe investigate the vertical metallicity gradients of five mono-age stellar populations between 0 and 11 Gyr for a sample of 18 435 dwarf stars selected from the cross-matched Tycho-Gaia Astrometric Solution (TGAS) and RAdial Velocity Experiment (RAVE) Data Release 5. We find a correlation between the vertical metallicity gradients and age, with no vertical metallicity gradient in the youngest population and an increasingly steeper negative vertical metallicity gradient for the older stellar populations. We also find that the intrinsic dispersion in metallicity increases steadily with age. Our results are consistent with a scenario that thin disk stars formed from a flaring thin star-forming disk.
A large-scale variability survey for the northern Galactic plane: KISOGP
Authors: Matsunaga Noriyuki ,   KISOGP team
Published: August 2018

AbstractWe have conducted a large-scale survey of variable stars in the northern Galactic plane, about 320 square degrees using Kiso Wide Field Camera attached to the 105-cm Schmidt telescope at Kiso observatory. In the KISOGP (KWFC Intensive Survey of the Galactic Plane), we collected 40–100 epoch I-band images between 2012 and 2017. In our survey region roughly 5 million stars exist down to the limiting magnitude of ~16.5 mag in I. In the initial data analysis, we detected a couple of thousands of variable stars including approximately 100 Cepheids and more than 700 Miras. More than 80 percents of them were not previously reported as variable stars, indicating that there are still many relatively bright variables to be found in the Galactic plane.
Assembly of the Galactic Halo System Based on Carbon-Enhanced Metal-Poor Stars
Authors: Lee Young Sun , Beers Timothy C. , Yoon Jinmi , Kim Young Kwang , Jeong Jaehun 
Published: August 2018

AbstractThere is growing evidence that, among the various subclasses of carbon-enhanced metal-poor (CEMP) stars, the outer halo of the Milky Way exhibits a higher frequency of CEMP-no stars (those having no over-abundances of heavy neutron-capture elements) compared with the CEMP-s stars (those with over-enhancements of the s-process elements), while the inner halo shows a higher frequency of CEMP-s stars. We map out fractions of CEMP-no and CEMP-s stars in the inner- and outer-halo populations, separated by their spatial distribution of carbonicity ([C/Fe]), a so-called “carbonicity map”, based on a sample of over 100,000 main-sequence turnoff stars with available spectroscopy from the Sloan Digital Sky Survey. The CEMP-no and CEMP-s objects are classified by different levels of absolute carbon abundances for our sample, A(C). We also present kinematic and orbital characteristics of these subclasses for each population. The contrast appearing in these characteristics provides critical constraints on the assembly history of the two primary stellar components of the Galactic halo.
Large-Scale Surveys of Pulsating Stars for Studying Stellar Populations in the Inner Galaxy
Authors: Matsunaga Noriyuki 
Published: August 2018

AbstractSurveys of pulsating stars in the inner Galaxy have been very limited, but recent large-scale surveys are rapidly bringing us new samples of various kinds of variable stars and new insights into stellar populations therein. Because of the severe interstellar extinction along the Galactic disc, the stellar populations in the inner Galaxy are more easily observed in the infrared, but even in the infrared the interstellar extinction may cause a serious problem in revealing their accurate characteristics. Here we review recent discoveries of Cepheids and Miras, two kinds of luminous pulsating stars with period–luminosity relation, in the inner Galaxy.
The Spatial Structure of the Galactic outer disk with LAMOST DR3 K giant stars
Authors: Wang Haifeng , Liu Chao , Deng Licai 
Published: August 2018

AbstractThe spatial structure of the Milky Way outer disk is characterized with ~ 70000 LAMOST DR3 K giants after carefully correction of their selection effects. By slicing the data into various Galactocentric radius bins, we are able to fit the vertical stellar density profile with a models composed of two isothermal-sheet disks and an oblate power-law halo. We find that although the thin disk is significantly flared, the radial surface density profile can extend to as far as 19 kpc. Beyond 12 kpc, only one thicker disk, rather than two disk components, are found in the samples. Moreover, the residual of the density profiles after subtracting the best fit models show different oscillation patterns in almost all range of detecting radius.
Developing an astrophysical line list for Keck/Nirspec observations of red giants in the Galactic centre
Authors: Thorsbro B. , Ryde N. , Rich R. M. , Schultheis M. , Fritz T. K. , Origlia L. 
Published: August 2018

AbstractA major avenue in the study of the Galaxy is the investigation of stellar populations and Galactic chemical evolution by stellar spectroscopy. Due to the dust obscuration, stars in the centre of the Galaxy can only be observed in the near-IR wavelength region. However, existing line lists in this wavelength region are demonstratively not of good enough quality for use in stellar spectroscopy. In response to this, we have developed an empirical astrophysical line list in the K-band based on modelling against the Sun and testing against Arcturus. Of ca. 700 identified interesting lines about 570 lines have been assigned empirically determined values.
New Proper Motions of the Small Magellanic Cloud Using HST and Implications for Milky Way Mass
Authors: Zivick P. , Kallivayalil N. , Linden S. , Fritz T. , Besla G. , van der Marel R. P. , Kozłowski S. , Geha M. C. , Kochanek C. S. , Anderson J. , Alcock C. R. 
Published: August 2018

AbstractAs new work on the proper motions (PMs) of the Large Magellanic Cloud (LMC) has come out, our view of the history of the Magellanic Clouds has evolved. We now believe they are on their first infall into the Milky Way (MW), having been tidally bound at the start of infall (though not necessarily now). Combining these observations with initial PMs of the Small Magellanic Cloud (SMC) suggests a new formation mechanism of the Magellanic Stream through the stripping of material from the SMC. However, large uncertainties remain in the exact mass of the LMC. We present a measurement of the systemic proper motions of the SMC from astrometry with the Wide Field Camera 3 (WFC3) on the Hubble Space Telescope (HST), covering a ~3 year baseline of 30 fields with background QSOs. We find these motions to be μW = −0.82 ± 0.06 mas/yr and μN = −1.23 ± 0.07 mas/yr. Combining these measurements with previous efforts in studying the Clouds will help constrain their interactions with each other and the MW, including the mass of the LMC and the MW, as well as provide new insight into the internal dynamics of the SMC.