bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meeting up for management control: bracketing interaction in innovation development
Authors: Bürkland Sirle , Zachariassen Frederik , Oliveira João 
Published: May 2019

PurposeThe purpose of this paper is to examine meetings as a form of meta-practice and investigate their role related to management control of innovation development.Design/methodology/approachThis research draws on case studies of two biotechnology firms operating in pharmaceuticals and medicine, which represent different contexts regarding the uncertainty and complexity of innovation development.FindingsThe study suggests two distinct roles of meetings in the context of innovation development: meetings as regulating and ordering; and meetings as a resource. In the first role, meetings serve as a regulative mechanism that brings together multiple elements of control into a system. Meetings as a meta-practice regulate and order by bracketing elements of innovation in time and space, rendering the innovation process more manageable and allowing actors to handle the complexity of knowledge. In the second role, meetings are used as a resource, sporadically intervening in the ongoing activities of innovation projects. The study explains how these two roles relate to the uncertainty and complexity of innovation development and have different implications for management control.Originality/valueThe study challenges the instrumental view of meetings by taking a closer look at their structuring potential in the organization. Understanding the roles of meetings provides another perspective on the functioning of management control and opens new avenues for studying the practices of control and decision-making.
Investor attention using the Google search volume index – impact on stock returns
Authors: Swamy Vighneswara , Dharani Munusamy 
Published: May 2019

Purpose
The purpose of this paper is to investigate whether the investor attention using the Google search volume index (GSVI) can be used to forecast stock returns. The authors also find the answer to whether the “price pressure hypothesis” would hold true for the Indian stock market.

Design/methodology/approach
The authors employ a more recent fully balanced panel data for the period from July 2012 to Jun 2017 (260 weeks) of observations for companies of NIFTY 50 of the National Stock Exchange in the Indian stock market. The authors are motivated by Tetlock (2007) and Bijl et al. (2016) to employ regression approach of econometric estimation.

Findings
The authors find that high Google search volumes lead to positive returns. More precisely, the high Google search volumes predict positive and significant returns in the subsequent fourth and fifth weeks. The GSVI performs as an useful predictor of the direction as well as the magnitude of the excess returns. The higher quantiles of the GSVI have corresponding higher excess returns. The authors notice that the domestic investor searches are correlated with higher excess returns than the worldwide investor searches. The findings imply that the signals from the search volume data could be of help in the construction of profitable trading strategies.

Originality/value
To the best of the authors knowledge, no paper has examined the relationship between Google search intensity and stock-trading behavior in the Indian stock market. The authors use a more recent data for the period from 2012 to 2017 to investigate whether search query data on company names can be used to predict weekly stock returns for individual firms. This study complements the prior studies by investigating the relationship between search intensity and stock-trading behavior in the Indian stock market.
Individual investors’ sophistication and expectations of risk and return
Authors: Stålnacke Oscar 
Published: May 2019

Purpose
The purpose of this paper is to investigate the relationship between individual investors’ level of sophistication and their expectations of risk and return in the stock market.

Design/methodology/approach
The author combines survey and registry data on individual investors in Sweden to obtain 11 sophistication proxies that previous research has related to individuals’ financial decisions. These proxies are related to a survey measure regarding individual investors’ expectations of risk and return in an index fund using linear regressions.

Findings
The findings in this paper indicate that sophisticated investors have lower risk and higher return expectations that are closer to objective measures than those of less-sophisticated investors.

Originality/value
These results are important, since they enhance the understanding of the underlying mechanisms through which sophistication can influence financial decisions.
Shedding new light on the (in)compatibility of chronic disease management with everyday life – social practice theory, mobile technologies and the interwoven time‐spaces of teenage life
Authors: Harries Tim , Rettie Ruth , Gabe Jonathan 
Published: May 2019

AbstractThis article uses a socio‐material approach, social practice theory, to provide new insights into the self‐management of chronic illness. It demonstrates how this theory can bridge arguments about the respective roles of social and individual influences, and how it can foreground an oft‐overlooked aspect of the issue – the demands of self‐care technologies and consequences for participation in social life. Drawing on interviews and focus groups with 25 young type‐1 diabetes outpatients in London, UK, the study points to the conflicts that occur when disease management technologies compete for time and space with the social practices of everyday life, and when self‐care tasks threaten to interrupt the flow of social life and make people feel ‘left behind’. The paper concludes that young people are disabled by the contingent position of self‐care activities in daily life, which oblige them to compromise either their physical health or their immersion in the social world. This disabling effect would be mitigated if social practices were reorganised to make them more amenable to the time‐space requirements of disease management. A social practice theory lens can help throw light onto this issue and make a valuable contribution to the study of the self‐management of chronic illness.
Cross‐boundary working: Implications forHRMtheory, methods, and practice
Authors: Kinnie Nicholas , Swart Juani 
Published: May 2019

AbstractMajor changes have taken place in work organisation, which originate predominantly from working across organisational boundaries. This paper argues for a more sophisticated approach to HRM that includes three types of cross‐boundary working, that is, intraorganisational, interorganisational, and transorganisational. Herein lies the contribution of our paper; we argue that we cannot assume a transition from one type of working to another because cross‐boundary forms of working coexist. We also need to understand the tensions of this simultaneity at the levels of the organisation/network, HRM systems, and the individual. We consider the impact of the simultaneous existence of these types of cross‐boundary working for the following: (a) theory, especially the development of HRM systems; (b) methods, including an activity‐based unit of analysis; and (c) practice, where we pay attention to the challenges of control, collaboration, and consistency.
Validation of 2017 classification criteria for adult and juvenile idiopathic inflammatory myopathies proposed by EULAR/ACR in Chinese patients
Authors: Zhang Xiaohui , Yang Xinlei , Ji Lanlan , Zhang Zhuoli 
Published: May 2019

AbstractObjectivesTo evaluate the ability of 2017 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM) to classify IIM in comparison with the 1975 Bohan and Peter criteria in Chinese patients.MethodsTwo hundred and twenty‐one inpatients with suspected IIM (including 40 children) were retrospectively included in this study. The performance of the 2017 EULAR/ACR criteria was evaluated by sensitivity, specificity, positive predictive value, negative predictive value and classification rate, in comparison to the 1975 criteria, with clinical diagnosis as the gold standard.ResultsThe sensitivity, specificity, positive predictive value, negative predictive value of the 2017 EULAR/ACR criteria in IIM classification were 92.7%, 87.0%, 90.1% and 90.4%, respectively, in contrast to the 1975 Bohan and Peter criteria of 84.0%, 52.2%, 61.8%, and 77.9%. The classification rate of the 2017 criteria was also much better than that of the 1975 criteria (90.2% vs 67.4%). The performance of the new criteria in general, as well as the new criteria with muscle biopsy was better. Most IIM patients were correctly further sub‐classified by the classification tree. The positive rate of myogenic lesions in electromyography, muscular inflammatory edema in magnetic resonance imaging and specific antibodies of myositis were significantly higher in the IIM group than those in the control group (P < 0.001, all).ConclusionsThe 2017 EULAR/ACR criteria exhibited high sensitivity, specificity, classification rate in the Chinese IIM patients, which was superior to the 1975 criteria. The new criteria showed potential as clinical classification criteria in the future.
Anacapa Toolkit: An environmental DNA toolkit for processing multilocus metabarcode datasets
Authors: Curd Emily E. , Gold Zack , Kandlikar Gaurav S. , Gomer Jesse , Ogden Max , O'Connell Taylor , Pipes Lenore , Schweizer Teia M. , Rabichow Laura , Lin Meixi , Shi Baochen , Barber Paul H. , Kraft Nathan , Wayne Robert , Meyer Rachel S. 
Published: May 2019

Abstract

Environmental DNA (eDNA) metabarcoding is a promising method to monitor species and community diversity that is rapid, affordable and non‐invasive. The longstanding needs of the eDNA community are modular informatics tools, comprehensive and customizable reference databases, flexibility across high‐throughput sequencing platforms, fast multilocus metabarcode processing and accurate taxonomic assignment. Improvements in bioinformatics tools make addressing each of these demands within a single toolkit a reality.

The new modular metabarcode sequence toolkit Anacapa (https://github.com/limey-bean/Anacapa/) addresses the above needs, allowing users to build comprehensive reference databases and assign taxonomy to raw multilocus metabarcode sequence data. A novel aspect of Anacapa is its database building module, “Creating Reference libraries Using eXisting tools” (CRUX), which generates comprehensive reference databases for specific user‐defined metabarcoding loci. The Quality Control and ASV Parsing module sorts and processes multiple metabarcoding loci and processes merged, unmerged and unpaired reads maximizing recovered diversity. DADA2 then detects amplicon sequence variants (ASVs) and the Anacapa Classifier module aligns these ASVs to CRUX‐generated reference databases using Bowtie2. Lastly, taxonomy is assigned to ASVs with confidence scores using a Bayesian Lowest Common Ancestor (BLCA) method. The Anacapa Toolkit also includes an r package, ranacapa, for automated results exploration through standard biodiversity statistical analysis.

Benchmarking tests verify that the Anacapa Toolkit effectively and efficiently generates comprehensive reference databases that capture taxonomic diversity, and can assign taxonomy to both MiSeq and HiSeq‐length sequence data. We demonstrate the value of the Anacapa Toolkit in assigning taxonomy to seawater eDNA samples collected in southern California.

The Anacapa Toolkit improves the functionality of eDNA and streamlines biodiversity assessment and management by generating metabarcode specific databases, processing multilocus data, retaining a larger proportion of sequencing reads and expanding non‐traditional eDNA targets. All the components of the Anacapa Toolkit are open and available in a virtual container to ease installation.
Allergy…No more fear of needles!
Authors: Traina Giovanni , Martelli Alberto G. , Fiocchi Alessandro Giovanni , Franco Valentina , Ronchi Barbara , Betti Federica 
Published: May 2019

AbstractNeedleless injection systems are nowadays widespread and are mainly used to overcome the common problems of needle injection systems, such as pain, hematoma, scar tissue formation, infection or abscess, possibility of accidentally injecting into a venous vessel, and transmission of infectious diseases. All these problems are independent of the type of drug injected and are exclusively related to the needle devices. Current needleless injection systems are a valuable tool, which is especially available for the administration of vaccines to large numbers of patients. Our experience focused in particular on the so‐called "jet injectors," of which one of the most valid representatives is Injex®. Our patent essentially concerns a medical needleless device, suitable to inject a subcutaneous AIT (allergy immunotherapy). The mechanism at the base of our device works with compressed air by means of a spring: It is very simple and similar to that of compressed air guns. Once the syringe has been filled, it is placed perpendicular to the skin, and then, the device is activated. The pressure vaporizes the drug, without changing or altering its chemical structure; it makes it pass through the epidermis, until it quickly reaches the subcutaneous layer, at a depth between 3.2 and 9.1 mm, without the patient feeling any pain. The entrance hole made by the needleless device in the epidermis is 0.17 mm rather than 0.39 mm of a normal needle. This type of administration also allows a uniform and spray diffusion of the drug, without causing localized inflammation, as it sometimes happens with normal syringe.
Fresh frozen cadaver workshops for general surgical training
Authors: Chai Debbi Q. , Naunton‐Morgan Richard , Hamdorf Jeffrey 
Published: May 2019

BackgroundThe technical proficiency of a surgeon is intricately linked to training and experience. Reduction in working hours, decreased operating time and ethical imperatives to protect patients have all resulted in a decrease in hands‐on experience. The introduction of laparoscopic procedures has also decreased trainees' exposure to open operative procedures not routinely performed in the current era.MethodsThe Clinical Training and Evaluation Centre at The University of Western Australia introduced the Core Skills Workshop for general surgical trainees in 2007. The workshop provides cadaveric dissection time for a range of open procedures. We describe in this article the logistics of setting up and running a cadaveric workshop, the performance and report our trainees' evaluation of the workshop.ResultsThe Clinical Training and Evaluation Centre has hosted 26 General Surgery Core Skills Workshops since 2007. There were 227 participants with 196 evaluations returned (response rate 86%). Feedback was strongly positive for the course meeting the participants' expectations as well as its contribution to their skillset. Participants value the use of cadavers and high instructor:student ratios along with performance of a large number of open procedures in the setting of a stress‐free workshop and looked forward to more similar courses in the future.ConclusionsFresh frozen cadaver workshops are of value in the face of current surgical training challenges in providing an efficient, effective and safe environment.
Recycled Blessings: An Investigative Case Study of a Rewrapped Egyptian Votive Mummy Using Novel and Established 3D Imaging Techniques
Authors: Raymond C. A. , Bevitt J. J. , Tristant Y. , Power R. K. , Lanati A. W. , Davey C. J. , Magnussen J. S. , Clark S. M. 
Published: May 2019

This case study was the first of its kind, where neutron computed tomography (CT) was applied to a wrapped mummified animal. Conventional X‐ray CT was also used to allow for meaningful comparison, and complementary data for a comprehensive investigation. Previous applications of both techniques are limited to metallic objects, such as bronze Buddhas. The mummy used in this study (IA.2402) is dated between the Third Intermediate Period (1069–664 bce) to Late Period (664–332 bce) according to the wrapping style, and was originally believed to contain a complete skeleton of a feline. However, precise date and provenance were unknown. Our results prove the presence of only partial juvenile feline remains, and provide a date range for artefact creation (900–804 bce ± 30) and alteration (367–204 bce ± 30). Therefore, this study implements an established imaging technique (neutron CT) in a novel way, while preserving and conserving the intrinsic value of the artefact through non‐destructive investigation.
Trial of labor versus elective repeat cesarean delivery in twin pregnancies after a previous cesarean delivery—A systematic review and meta‐analysis
Authors: Shinar Shiri , Agrawal Swati , Hasan Haroon , Berger Howard 
Published: May 2019

AbstractObjectiveTo perform a systematic review of success rates of trial of labor after cesarean (TOLAC) and maternal and neonatal outcomes in twin pregnancy versus elective repeat cesarean delivery (ERCD).MethodsWe searched MEDLINE, EMBASE, and Web of Science from data inception to May 2018 with no language or regional restrictions, to identify all studies that compared twin TOLAC and ERCD for maternal and/or neonatal outcomes. The Newcastle‐Ottawa Scale was used to assess the methodological quality of the included studies. We assessed the pooled relative risk and mean difference using a random‐effects model. The pooled event rates for successful VBAC, cesarean delivery for twin B after vaginal delivery of twin A, and uterine rupture were determined.ResultsOf the 841 citations identified, 10 were eligible for analysis (2336 TOLAC cases and 5763 ERCD cases). The pooled event rates for successful VBAC and uterine rupture during TOLAC were 72.2% (95% CI 59.7%‐83.2%) and 0.87% (95% CI 0.51%‐1.31%), respectively. TOLAC was associated with a significantly higher risk of neonatal death (RR 3.02 [95% CI 1.07‐8.54]) with no significant differences in mean gestational age at birth, NICU admission rates, or 5‐minute Apgar <7. Although the risk for maternal infectious morbidity was significantly lower with TOLAC (RR 0.48 [95% CI 0.25‐0.90]), risks of uterine dehiscence, blood transfusions, and hysterectomy were comparable.ConclusionsTwin TOLAC is associated with a relatively high rate of successful vaginal delivery and a low risk of uterine rupture. The finding of higher neonatal mortality rates may be influenced by prematurity, but requires further investigation.
A cross‐cultural approach to the adoption of open educational resources in higher education
Authors: Jung Insung , Lee Jihyun 
Published: May 2019

AbstractThe factors affecting the adoption of open educational resources (OER) in higher education have become a research topic of great interest as OER continue to be widely used in universities, affecting the quality of teaching and learning. The reasons for OER adoption are diverse, across both individual educators and cultural environments. This study explored determinants of OER adoption by university educators in three cultural contexts utilizing the Unified Theory of Acceptance and Use of Technology (UTAUT2). Data on educators' behavioral intention to adopt OER were collected from 152 educators in three countries, Korea, Japan and the United States. In every culture, habit was the strongest determinant of this behavioral intention. Other highly significant factors affecting OER adoption by educators varied by culture. In Korea, the strongest determinant was performance expectancy, in Japan it was social influence and in the United States it was price value. The moderating effect of culture was significant on three paths of the model, and the cultural specificity affecting OER adoption was substantial. Theoretical and practical implications related to the UTAUT2 model and OER policy are discussed.
Ca2+ signalling plays a role in celastrol‐mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats
Authors: Wong Vincent Kam Wai , Qiu Congling , Xu Su‐Wei , Law Betty Yuen Kwan , Zeng Wu , Wang Hui , Michelangeli Francesco , Dias Ivo Ricardo De Seabra Rodrigues , Qu Yuan Qing , Chan Tsz Wai , Han Yu , Zhang Ni , Mok Simon Wing Fai , Chen Xi , Yu Lu , Pan Hudan , Hamdoun Sami , Efferth Thomas , Yu Wen Jing , Zhang Wei , Li Zheng , Xie Yuesheng , Luo Riqiang , Jiang Quan , Liu Liang 
Published: May 2019

Background and PurposeCelastrol exhibits anti‐arthritic effects in rheumatoid arthritis (RA), but the role of celastrol‐mediated Ca2+ mobilization in treatment of RA remains undefined. Here, we describe a regulatory role for celastrol‐induced Ca2+ signalling in synovial fibroblasts of RA patients and adjuvant‐induced arthritis (AIA) in rats.Experimental ApproachWe used computational docking, Ca2+ dynamics and functional assays to study the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase pump (SERCA). In rheumatoid arthritis synovial fibroblasts (RASFs)/rheumatoid arthritis fibroblast‐like synoviocytes (RAFLS), mechanisms of Ca2+‐mediated autophagy were analysed by histological, immunohistochemical and flow cytometric techniques. Anti‐arthritic effects of celastrol, autophagy induction, and growth rate of synovial fibroblasts in AIA rats were monitored by microCT and immunofluorescence staining. mRNA from joint tissues of AIA rats was isolated for transcriptional analysis of inflammatory genes, using siRNA methods to study calmodulin, calpains, and calcineurin.Key ResultsCelastrol inhibited SERCA to induce autophagy‐dependent cytotoxicity in RASFs/RAFLS via Ca2+/calmodulin‐dependent kinase kinase‐β–AMP‐activated protein kinase–mTOR pathway and repressed arthritis symptoms in AIA rats. BAPTA/AM hampered the in vitro and in vivo effectiveness of celastrol. Inflammatory‐ and autoimmunity‐associated genes down‐regulated by celastrol in joint tissues of AIA rat were restored by BAPTA/AM. Knockdown of calmodulin, calpains, and calcineurin in RAFLS confirmed the role of Ca2+ in celastrol‐regulated gene expression.Conclusion and ImplicationsCelastrol triggered Ca2+ signalling to induce autophagic cell death in RASFs/RAFLS and ameliorated arthritis in AIA rats mediated by calcium‐dependent/‐binding proteins facilitating the exploitation of anti‐arthritic drugs based on manipulation of Ca2+ signalling.