bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ambient Noise Tomography Across the Taiwan Strait, Taiwan Island, and Southwestern Ryukyu Arc: Implications for Subsurface Slab Interactions
Authors: Ai Sanxi , Zheng Yong , Xiong Cheng 
Published: January 2019

AbstractThe subduction flipping in the Taiwan region leads to complexities in the lithospheric structure. To better understand the arc‐continental collision process in this zone, we construct a 3‐D lithospheric model of the Taiwan Strait, Taiwan Island, and southwestern Ryukyu Arc. In the middle to lower crust, low velocities are mainly located beneath the Ryukyu Trough and the rifted basins in the Taiwan Strait, and high velocities are imaged in the Kuanyin and Penghu Platforms. Likely, the Kuanyin and Penghu Platforms act as relatively strong barriers that block the persistent westward advance of the western deformation front of the Taiwan mountain belt, as manifested by shape of the deformation front that withdraws to the east in the basement highs. In the mantle, high velocities are observed beneath the Central Range and Ryukyu Arc, which is interpreted as the two oppositely oriented slab subductions, that is, subduction of the Philippine Sea slab in the northeast Taiwan and Eurasian slab subduction in south Taiwan. Based on the vertical transects through our 3‐D model, we find that the subduction polarity has flipped in north Taiwan, and the tectonic framework in central Taiwan is in the process of subduction polarity reversal. We also image significant low mantle velocities beneath the North Taiwan Volcanic Zone and Taihsi Basin, which may be related to the breakoff of the subducting Eurasian slab. In addition, we propose that the inherited weakness of the Taihsi Basin may have facilitated the slab breakoff in central Taiwan.
Floquet group theory and its application to selection rules in harmonic generation
Authors: Neufeld Ofer , Podolsky Daniel , Cohen Oren 
Published: January 2019

AbstractSymmetry is one of the most generic and useful concepts in science, often leading to conservation laws and selection rules. Here we formulate a general group theory for dynamical symmetries (DSs) in time-periodic Floquet systems, and derive their correspondence to observable selection rules. We apply the theory to harmonic generation, deriving closed-form tables linking DSs of the driving laser and medium (gas, liquid, or solid) in (2+1)D and (3+1)D geometries to the allowed and forbidden harmonic orders and their polarizations. We identify symmetries, including time-reversal-based, reflection-based, and elliptical-based DSs, which lead to selection rules that are not explained by currently known conservation laws. We expect the theory to be useful for ultrafast high harmonic symmetry-breaking spectroscopy, as well as in various other systems such as Floquet topological insulators.
A child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessation
Authors: Violari Avy , Cotton Mark F. , Kuhn Louise , Schramm Diana B. , Paximadis Maria , Loubser Shayne , Shalekoff Sharon , Da Costa Dias Bianca , Otwombe Kennedy , Liberty Afaaf , McIntyre James , Babiker Abdel , Gibb Diana , Tiemessen Caroline T. 
Published: January 2019

AbstractUnderstanding HIV remission in rare individuals who initiated antiretroviral therapy (ART) soon after infection and then discontinued, may inform HIV cure interventions. Here we describe features of virus and host of a perinatally HIV-1 infected child with long-term sustained virological control. The child received early limited ART in the Children with HIV Early antiRetroviral therapy (CHER) trial. At age 9.5 years, diagnostic tests for HIV are negative and the child has characteristics similar to uninfected children that include a high CD4:CD8 ratio, low T cell activation and low CCR5 expression. Virus persistence (HIV-1 DNA and plasma RNA) is confirmed with sensitive methods, but replication-competent virus is not detected. The child has weak HIV-specific antibody and T cell responses. Furthermore, we determine his HLA and KIR genotypes. This case aids in understanding post-treatment control and may help design of future intervention strategies.
Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie
Authors: Sun Xiaohan , Ding Yan , Zhan Meixiao , Li Yan , Gao Dongqing , Wang Guiping , Gao Yang , Li Yong , Wu Shian , Lu Ligong , Liu Qingxin , Zhou Zizhang 
Published: January 2019

AbstractThe Hippo pathway plays an important role in organ development and adult tissue homeostasis, and its deregulation has been implicated in many cancers. The Hippo signaling relies on a core kinase cascade culminating in phosphorylation of the transcription coactivator Yorkie (Yki). Although Yki is the key effector of Hippo pathway, the regulation of its protein stability is still unclear. Here, we show that Hippo pathway attenuates the binding of a ubiquitin-specific protease Usp7 to Yki, which regulates Hippo signaling through deubiquitinating Yki. Furthermore, the mammalian homolog of Usp7, HAUSP plays a conserved role in regulating Hippo pathway by modulating Yap ubiquitination and degradation. Finally, we find that the expression of HAUSP is positively correlated with that of Yap, both showing upregulated levels in clinical hepatocellular carcinoma (HCC) specimens. In summary, our findings demonstrate that Yki/Yap is stabilized by Usp7/HAUSP, and provide HAUSP as a potential therapeutic target for HCC.
γ-Aminobutyric Acid Promotes Chloroplast Ultrastructure, Antioxidant Capacity, and Growth of Waterlogged Maize Seedlings
Authors: Salah Akram , Zhan Ming , Cao Cougui , Han Yuling , Ling Lin , Liu Zhihui , Li Ping , Ye Miao , Jiang Yang 
Published: January 2019

Abstractγ-aminobutyric acid (GABA) is a small signaling molecule that accumulates rapidly in plants exposed to various stresses; however, it has not been applied in regulating waterlogging tolerance in maize seedlings. Here, the effect of exogenous application of GABA in the determined optimal concentration was performed on seedlings of two maize cultivars under waterlogging treatments initiated at 3-leaf (V3) and 5-leaf stages (V5) in repeated experiments in 2016 and 2017. Chloroplast ultrastructure, photosynthesis, antioxidant capacity, and reactive oxygen species (ROS) production in the leaves were examined and compared with the corresponding values under normal soil water treatment (CK) and waterlogging treatment (WL). Compared with WL treatment, application of GABA significantly increased aboveground and root dry matter by 19.0% and 61.0%, promoted photosynthetic rate and chlorophyll content by 19.8% and 36.0%, increased the number of grana per chloroplast by 36.0%, fortified antioxidants (SOD, POD, CAT, GR, APX, VC) activities by 14.7–42.7%, and reduced the content of MDA, H2O2, and O2− by 30.5%, 32.5%, and 21.8%, respectively (p < 0.05). Collectively, GABA application was shown to promote the growth of maize seedlings under waterlogging, by down regulating ROIs-producing enzymes, activating antioxidant defense systems, and improving chloroplast ultrastructure and photosynthetic traits.
Biomarkers of optical coherence tomography in evaluating the treatment outcomes of neovascular age-related macular degeneration: a real-world study
Authors: Lai Tso-Ting , Hsieh Yi-Ting , Yang Chung-May , Ho Tzyy-Chang , Yang Chang-Hao 
Published: January 2019

AbstractThis study evaluated the characteristic changes in optical coherence tomography (OCT) biomarkers in neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor drugs and their relationship with visual outcomes at 1-year follow-up in a real-world setting. We retrospectively reviewed the medical records of 126 eyes with nAMD treated with either intravitreal ranibizumab or aflibercept, including ophthalmologic examinations and spectral-domain OCT at baseline and months 3, 6, and 12 after first injection. Treatment response of intraretinal cysts (IRCs), subretinal fluid (SRF), and pigment epithelial detachment (PED), and the correlation between best-corrected visual acuity (BCVA) changes and these OCT biomarkers were analyzed. After an average of 5.1 ± 1.5 injections, 33.3% of eyes with PED showed resolution at month 12, a significantly lower proportion than for IRCs (53.8%) or SRF (51.6%). BCVA improvement at 1 year was negatively associated with PED at baseline and with IRCs or PED at month 12. Persistence of IRCs at month 12 was associated with degeneration morphology of IRCs at baseline and non-resolved cysts at month 3 after loading. In conclusions, IRCs and PED are associated with poor visual improvement in nAMD in a real-world setting. Both IRCs and SRF responded better than PED to anti-VEGF therapy.
Cream Cheese-Derived Lactococcus chungangensis CAU 28 Modulates the Gut Microbiota and Alleviates Atopic Dermatitis in BALB/c Mice
Authors: Kim Jong-Hwa , Kim Kiyoung , Kim Wonyong 
Published: January 2019

AbstractAtopic dermatitis (AD) has a drastic impact on human health owing to complex skin, gut microbiota, and immune responses. Some lactic acid bacteria (LAB) are effective in ameliorating AD; however, the alleviative effects of dairy products derived from these LAB remain unclear. In this study, the efficacies of Lactococcus chungangensis CAU 28 (CAU 28) cream cheese and L. chungangensis CAU 28 dry cells were evaluated for treating AD in an AD mouse model. Overall, CAU 28 cream cheese administration was more effective against AD than L. chungangensis CAU 28 dry cells. Faeces from CAU 28 cream cheese-administered mice had increased short chain fatty acid, butyrate, acetate, and lactic acid levels, as well as butyrate-producing bacteria, including Akkermansia, Bacteroides, Lactobacillus, and Ruminococcus. Furthermore, oral CAU 28 cream cheese administration resulted in regulatory T cell (Treg)-mediated suppression of T helper type 2 (Th2) immune responses in serum and mRNA expression levels in the ileum. Oral CAU 28 cream cheese further reduced IgE levels, in addition to eosinophil and mast cell numbers. Therefore, CAU 28 cream cheese administration induced a coordinated immune response involving short-chain fatty acids and gut microbiota, indicating its potential for use as a supplement for AD mitigation.
Intermolecular distance measurement with TNT suppressor on the M13 bacteriophage-based Förster resonance energy transfer system
Authors: Kim Inhong , Song Hyerin , Kim Chuntae , Kim Minwoo , Kyhm Kwangseuk , Kim Kyujung , Oh Jin-Woo 
Published: January 2019

AbstractAn M13 bacteriophage-based Förster resonance energy transfer (FRET) system is developed to estimate intermolecular distance at the nanoscale using a complex of CdSSe/ZnS nanocrystal quantum dots, genetically engineered M13 bacteriophages labeled with fluorescein isothiocyanate and trinitrotoluene (TNT) as an inhibitor. In the absence of trinitrotoluene, it is observed that a significant spectral shift from blue to green occur, which represents efficient energy transfer through dipole-dipole coupling between donor and acceptor, or FRET-on mode. On the other hand, in the presence of trinitrotoluene, the energy transfer is suppressed, since the donor-to-acceptor intermolecular distance is detuned by the specific capturing of TNT by the M13 bacteriophage, denoted as FRET-off mode. These noble features are confirmed by changes in the fluorescence intensity and the fluorescence decay curve. TNT addition to our system results in reducing the total energy transfer efficiency considerably from 16.1% to 7.6% compared to that in the non-TNT condition, while the exciton decay rate is significantly enhanced. In particular, we confirm that the energy transfer efficiency satisfies the original intermolecular distance dependence of FRET. The relative donor-to-acceptor distance is changed from 70.03 Å to 80.61 Å by inclusion of TNT.
Tunable Backward Terahertz-wave Parametric Oscillation
Authors: Nawata Kouji , Tokizane Yu , Takida Yuma , Minamide Hiroaki 
Published: January 2019

AbstractBackward optical parametric oscillation has attracted attention for cavityless spectral narrowband generation based on perfect photon conversion. Few demonstrations have shown its potential from the aspect of nonlinear photonics; therefore, the mechanisms of momentum conservation among interacting light waves have been concealed by the restricted configuration under the phase-matching condition of periodically poled structures. Here, we unveil a tunable mechanism in the terahertz region by active control of the phase-matching condition. The tunability of backward terahertz-wave parametric oscillation is investigated using a quasi-collinear phase-matching model and its frequency range from the sub-terahertz to terahertz region is identified. Transform-limited terahertz-wave pulse is achieved simply by installing a device on the pump propagating line with no cavity. Moreover, the cascading terahertz-wave generation enhances the photon conversion efficiency, thus making nonlinear optics and its applications more promising. The results highlight new capabilities for using modern ferroelectric materials and encourage further research on nonlinear optics.
On the convective heat and zero nanoparticle mass flux conditions in the flow of 3D MHD Couple Stress nanofluid over an exponentially stretched surface
Authors: Ramzan Muhammad , Sheikholeslami Mohsen , Saeed Maria , Chung Jae Dong 
Published: January 2019

AbstractThree dimensional problems reflect more imperative understanding to real world issues in comparison to two dimensional problems. Keeping this fact in mind, a mathematical model is designed to deliberate the 3D magnetohydrodynamic couple stress nanofluid flow with joule heating and viscous dissipation effects past an exponential stretched surface. The analysis is performed keeping in mind the physical effects of Brownian motion and thermophoresis combined with convective heat condition. This paper also distinctly introduces a more realistic boundary constraint for nanoliquid flow model. For instance, zero mass flux condition has been instituted for the first time for 3D couple stress nanofluid model as far as the exponential stretched surface is concerned. Self-similar transformations are engaged to obtain a system of ordinary differential equations possessing high nonlinearity from the system of boundary layer partial differential equations. Analytic solution is constructed in the form of series using Homotopy Analysis Method (HAM). Numerically calculated values of Skin friction and local Nusselt number are also given with suitable analysis. Moreover, the influences of sundry parameters on velocity distribution, and heat and mass transfer rates are deliberated and depicted through relevant graphs. The results obtained clearly show that the Biot number and Hartmann number possess increasing effect on temperature distribution. To authenticate our obtained results, a comparison in limiting case is also given.
Up-regulation of activation-induced cytidine deaminase and its strong expression in extra-germinal centres in IgG4-related disease
Authors: Gion Yuka , Takeuchi Mai , Shibata Rei , Takata Katsuyoshi , Miyata-Takata Tomoko , Orita Yorihisa , Tachibana Tomoyasu , Yoshino Tadashi , Sato Yasuharu 
Published: January 2019

AbstractImmunoglobulin (Ig) G4-related disease (IgG4-RD) is a systemic disorder involving benign mass formation due to fibrosis and intense lymphoplasmacytosis; the chronic inflammation associated with the disease might also contribute to oncogenesis. Activation-induced cytidine deaminase (AID), normally expressed in germinal centre activated B-cells, is an enzyme that edits DNA/RNA and induces somatic hypermutation and Ig class switching. AID expression is strictly controlled under physiological conditions; however, chronic inflammation and some infectious agents induce its up-regulation. AID is overexpressed in various cancers and may be important in chronic inflammation-associated oncogenesis. We examined AID expression in IgG4-related sialadenitis (n = 14), sialolithiasis (non-specific inflammation, n = 13), and normal submandibular glands (n = 13) using immunohistochemistry and quantitative real-time polymerase chain reaction (qPCR). Immunohistochemistry revealed significantly more AID-expressing cells in IgG4-related sialadenitis than in sialolithiasis or normal submandibular gland samples (P = 0.02 and P < 0.01, respectively); qPCR yielded similar results. Thus, AID was significantly more up-regulated and had higher expression in extra-germinal centres in IgG4-RD than in non-specific inflammation or normal conditions. This report suggests that IgG4-RD has several specific causes of AID up-regulation in addition to inflammation. Furthermore, chronic inflammation-associated AID-mediated oncogenesis is possible in IgG4-RD.
A Large-Scale Comparison of Main Concept Production Between Persons With Aphasia and Persons Without Brain Injury
Authors: Dalton Sarah Grace Hudspeth , Richardson Jessica D. 
Published: January 2019

Purpose
The purposes of this study are to provide clinicians and researchers with introductory psychometric data for the main concept analysis (MCA), a measure of discourse informativeness, and specifically, to provide descriptive and comparative statistical information about the performance of a large sample of persons not brain injured (PNBIs) and persons with aphasia (PWAs) on AphasiaBank discourse tasks.

Method
Transcripts of 5 semi-spontaneous discourse tasks were retrieved from the AphasiaBank database and scored according to detailed checklists and scoring procedures. Transcripts from 145 PNBIs and 238 PWAs were scored; descriptive statistics, median tests, and effect sizes are reported.

Results
PWAs demonstrated overall lower informativeness scores and more frequent production of statements that were inaccurate and/or incomplete. Differences between PNBIs and PWAs were observed for all main concept measures and stories. Comparisons of PNBIs and aphasia subtypes revealed significant differences for all groups, although the pattern of differences and strength of effect sizes varied by group and discourse task.

Conclusions
These results may improve the investigative and clinical utility of the MCA by providing descriptive and comparative information for PNBIs and PWAs for standardized discourse tasks that can be reliably scored. The results indicate that the MCA is sensitive to differences in discourse as a result of aphasia.

Supplemental Material

https://doi.org/10.23641/asha.7485647
Role of reactive power (STATCOM) in the planning of distribution network with higher EV charging level
Authors: Zaidi Arsalan Hussain , Sunderland Keith , Conlon Michael 
Published: January 2019

In recent years, new trends in electrification of the transport sector have been a major concern for distribution grid operators. New types of flexible, uncontrollable loads, such as EV, influence the reliability of distribution networks. This work is related to the distribution system planning framework, with a particular focus on uncoordinated flexible EV loads. The main focus is the enhancement of the hosting capacity of EVs on distribution networks, while maintaining power quality (especially voltage magnitude and voltage unbalance), which is ultimately a pre‐requisite for increasing prosumer engagement. Several EV charging scenarios, in the context of UK/Irish distribution networks with increased penetration of EV prosumers are considered. The results show that reactive power compensation through STATCOM, in the context of EV integration, can provide continuous voltage support and thereby facilitate 90% penetration of network customer EV connections at a normal EV charging rate (3.68 kW). If fast charging (up to 11 kW) is employed, <30% of network EV customers can be accommodated due to bottlenecks presented by the substation transformer loading.
Common grounded wide voltage‐gain range DC–DC converter for fuel cell vehicles
Authors: Bi Huakun , Jia Cong 
Published: January 2019

In order to meet the requirements of the fuel cell stack power interface converter applied in the fuel cell vehicles, a common ground wide voltage‐gain range DC–DC converter is proposed. On the input voltage side, an interleaved structure is adopted in this converter to reduce the input current ripple. On the output voltage side, two series capacitors are combined with a diode–capacitor structure to improve the voltage gain and reduce the voltage stress of power semiconductors and capacitors. As a result, the efficiency and reliability of the proposed converter can be improved. The operating principle, steady‐state characteristic, parameter design, efficiency calculation, and comparison with other converters are analysed. A 1.6 kW prototype of the proposed converter with the 400 V output voltage has been developed to validate the analytical results. Theoretical analysis and experimental results show that the proposed converter can meet the requirements of a fuel cell stack power interface converter and is suitable for use as a fuel cell stack power interface converter applied in fuel cell vehicles.
Preliminary study on the structure design of 330 KV GIS with three phase in one tank
Authors: Wenlong Pang , Xixiu Wu , Shimin Cheng , Shipu Wu 
Published: January 2019

This paper focus on the research about the probability and practicability of 330 kV GIS structure design with three phase in one tank， which represents the miniaturisation and compact developing trend of GIS. The design principle is proposed according to the volume of three phase in one tank (structure A) is generally smaller than that of the sum volume of three single phase (structure B). Then, the dimension size of 330 kV GIS with structure A is presented. To solve the weak insulation‐level problem between phases of structure A, which prevents it from being used in high‐voltage power system especially above 330 kV, an electromagnetic‐temperature‐flow multi‐physical field coupling model considering eddy effect and skin effect is established to analyse the influencing factors on the insulation level of internal GIS. Therefore， the insulation level between the phases of structure A is calculated under the condition of power frequency and short circuit, respectively. The results show that the insulation margin of 330 kV GIS with structure A is enough and completely meet the insulation requirement of GIS. Furthermore, compared with structure B, structure A has lower temperature rise and energy consumption.
Influence of electric vehicle access mode on the static voltage stability margin and accommodated capacity of the distribution network
Authors: Tong Xiangqian , Ma Qiao , Tang Kaiyu , Liu Huakun , Li Cheng 
Published: January 2019

The electric vehicle, if accessed in the distribution network disorderly and extensively, will influence the safe, stable, and economic operation of the network, due to the characteristics of its randomness, intermittency, and duality with source and load. Here, the power demand models of different electric vehicles were established by analysing the behaviour of electric vehicle loads attributed to different users, and the spatial‐temporal distribution pattern of various electric vehicle loads in the distribution network was predicted with the Monte–Carlo method. Based on this regular pattern, an evaluation method for the adaptability of the distribution network to electric vehicles was proposed. Finally, the influence of electric vehicle loads under different access modes on the static voltage stability margin was tested with the IEEE33 node distribution network.