bluuebunny/crossref_metadata_2025_split huggingface dataset:
Legal dissemination protections in community-based participatory health equity research
Authors: Boutain Doris M , Sanon Rosemberg Marie-Anne , Kim Eunjung , Evans-Agnew Robin A 
Published: November 2024

Background There are legal protections for nurse researchers at public universities who employ community-based participatory research (CBPR) in research about social or health inequities. Dissemination of CBPR research data by researchers or participants may divulge unjust laws and create an imperative for university involvement. Research Question What are United States-based legal dissemination protections for CBPR health equity nurse researchers? Research Design Three case examples employing CBPR are examined: 1) a mixed methods study with participants reporting illegal discrimination in a municipal initiative about capacity building in community-based organizations serving children; 2) a visual methods study exposing potential clean air law violations in environmental justice research; and 3) a study examining workload violations and illegal discrimination among hotel workers. Participants and Research Context The cases involved participants from protected social class backgrounds. The research is described with respect to: background, funding, research purpose, and research team; research participants’ power and legal vulnerability; dissemination of relevant research information balancing vulnerability and power; research dissemination issues; potential legal issues involved; and laws researchers may use. Ethical Considerations IRB approval was obtained for the studies. Using a social justice ethical framework, studies highlight actual or potential legal aspects of data dissemination in the context of gathering data about injustice. Findings Legal protections for research data dissemination, whistleblower protection, research advancement protection, anti-harassment protection, false claims, defamation, and visual data liabilities are described. Conclusion Knowledge of legal research data dissemination protections is an essential competency for nurse researchers invested in uplifting social justice.
Early Palliative Care in Advanced Non-Small Cell Lung Cancer Patients: A Meta-Analysis
Authors: Liu Jie , Cheng Wei , Du Jie , Li Yamin 
Published: November 2024

Objective This study aims to assess the efficacy of Early Palliative Care (EPC) in non-small cell lung cancer (NSCLC) through a meta-analysis approach. Methods A computerized search was conducted in databases such as PubMed, Cochrane Library, Scopus, Embase, and Web of Science for prospective randomized controlled trials (RCTs) investigating the application of EPC in advanced NSCLC. Outcome measures including Overall Survival (OS), quality of life, and psychological status were extracted and subjected to pooled analysis. Results After the computerized search, a total of 7 studies comprising 1185 participants were included, with 597 patients receiving EPC intervention and 588 patients receiving Standard Care (SC) intervention. Three studies reported OS after the intervention, demonstrating a significant improvement in OS for patients receiving EPC (pooled HR = 1.60, 95% CI: 1.22, 1.98). Five studies analyzed the Functional Assessment of Cancer Therapy (FACT) scores after the intervention, revealing a significant improvement in FACT scores for patients receiving EPC (pooled SMD = 1.18, 95% CI: 1.04, 1.31). No significant differences were found in anxiety and depression scores between the 2 interventions in the 5 studies. Conclusion In advanced NSCLC, EPC provides benefits in terms of increased survival rates and improved quality of life. EPC should be considered as part of multidisciplinary treatment for patients with advanced NSCLC.
Factors Influencing Immunotherapy Outcomes in Cancer: Sarcopenia and Systemic Inflammation
Authors: Ucgul Enes , Guven Deniz Can , Ucgul Aybala Nur , Ozbay Yakup , Onur Mehmet Ruhi , Akin Serkan 
Published: November 2024

Background Immunotherapy has shown promise in treating various subtypes of metastatic cancers, but many patients are frail and may have compromised immune systems, which can influence treatment outcomes. Sarcopenia, a condition characterized by loss of muscle mass and systemic inflammation, is a potential factor that may negatively impact the response to immunotherapy. However, more data must be collected on the extent of its influence. Therefore, this study aims to investigate the effects of sarcopenia, systemic inflammation, and Eastern Cooperative Oncology Group Performance Status (ECOG PS) on the response to immunotherapy. Methods We enrolled 100 patients treated with immune checkpoint inhibitors between 2015 and 2021 who underwent computed tomography of the abdomen before the first immunotherapy dose. This study was conducted retrospectively. Gender-specific thresholds were used for the diagnosis of sarcopenia. C-reactive protein (CRP), erythrocyte sedimentation rate, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), albumin, and lactate dehydrogenase (LDH) were used as markers of systemic inflammation. Systemic inflammatory markers and sarcopenia were assessed using univariable and multivariable analyses for overall survival (OS) and progression-free survival (PFS). Results Sarcopenia was found to be a significant prognostic factor associated with poor PFS (HR, 2.33; 95% confidence interval [CI], 1.45-3.74; P < 0.001). In addition, hypoalbuminemia was identified as a significant prognostic factor for predicting OS (HR, 2.10; 95% CI, 1.21-3.66; P = 0.008). Conclusions Closer monitoring and prevention of sarcopenia may enhance both OS and PFS. Additionally, our composite model may assist oncologists in predicting responses to immunotherapy more accurately. However, further prospective studies are needed to validate these findings.
Where Is Capitalism? Unmasking Its Hidden Role in Psychology
Authors: Bettache Karim 
Published: November 2024

This article critically examines the pervasive yet often-neglected influence of capitalism on psychological processes and human behavior. While capitalist ideologies like neoliberalism have entered the mainstream in psychology, there remains a lack of deeper engagement with the foundations of capitalism. The article argues that capitalism generates distinct cultural syndromes that emerged from the unique historical experiences of Western societies and are deeply rooted in the core principles of capitalism: profit motive, market competition, and private property ownership. The article then argues that these principles manifest as capitalist cultural syndromes termed the “gain primacy,” “zero-sum rivalry,” and “ownership” syndromes, which collectively drive a self-enhancement agenda resulting in an overarching “individualist syndrome.” It then explores how these syndromes maintain and reproduce social inequalities. By adopting a critical-historical approach, this article situates its analysis within a broader critique of capitalism, aiming to illuminate its impact on human thought, behavior, and well-being. Public Abstract Our thoughts, behaviors, and well-being are deeply influenced by the economic system we live in—capitalism. While psychologists have explored capitalist ideologies like neoliberalism, they often overlook capitalism’s core foundations driving inequality. This work argues that capitalism, rooted in Western colonial history, generates powerful cultural narratives prioritizing profit, competition, and private ownership. These capitalist principles manifest as pervasive societal mindsets obsessed with personal gain, viewing life as a zero-sum rivalry, and deriving self-worth from possessions. Collectively, they breed an individualistic syndrome of selfish striving at the expense of community. By understanding how these capitalist cultural forces psychologically shape us, maintaining oppressive societal hierarchies, we can reimagine economic systems that truly uplift the human spirit across all peoples and the planet we share. Unveiling capitalism’s influence is crucial to recover from its alienating effects and envision liberating alternatives.
National Trends in Healthcare Expenditures for the Management of Skin Cancer in the United States
Authors: Ma Bryan , James Matthew T. , Chan An-Wen , Mydlarski P. Régine 
Published: November 2024

Background: Malignant melanoma and keratinocyte carcinomas account for a substantial proportion of healthcare expenditures in the United States. Objective: To estimate trends in the economic burden of skin cancer in the United States between 1996 and 2016. Methods: The Disease Expenditure Project and Global Burden of Disease databases were used to estimate annual total costs and population-standardized rates of change for skin cancer-related healthcare spending. Results: Skin cancer expenditures totaled $23.4 billion in 2016, of which $1.4 billion (95% CI: $1.3-$1.6 billion) was melanoma-related and $22 billion (95% CI: $18-$28 billion) was keratinocyte carcinoma-related. Most spending on skin cancer management occurred in ambulatory care settings [60.7% (95% CI: 57.7%-64.3%) for melanoma and 87.8% (95% CI: 87.2%-88.2%) for keratinocyte carcinoma]. Pharmaceutical costs for melanoma have increased since 2010 to $365 million (95% CI: $327-$416 million), which represents 26.1% (95% CI: 22.6%-29.3%) of total melanoma expenditure. Conclusions: Skin cancer management in the United States is costly. Expenditures have increased substantially since 1996 without signs of plateauing in recent years.
The role of collaborative governance in translating national cancer programs into network-based practices: A longitudinal case study in Canada
Authors: Tremblay Dominique , Usher Susan , Bilodeau Karine , Touati Nassera 
Published: November 2024

Objectives Networks (multiple organizations or actors coordinating their activities towards a common goal) have been promoted in the cancer programs of a number of countries. But there is little empirical evidence on whether and how they overcome the siloed functioning endemic in specialized domains. This study examines how collaborative governance takes shape to support integrated network-based practices within a prescribed national cancer program. Methods A longitudinal qualitative single-case study was conducted of the Quebec cancer network in Canada. Data were collected in 2018-2020 through semi-structured interviews with stakeholders ( n = 37) involved in regional and/or national cancer network structures and a review of documents ( n = 45) generated at national and regional level. Abductive thematic analysis during and post-field work was based on Emerson’s collaborative governance framework. It aimed to identify how collaborative governance mechanisms (principled engagement, shared motivation and capacity for joint action) were activated in the network, and their contribution to translating a national cancer program into network-based practices at the point of care. Results Principled engagement was driven through interdisciplinary committees at national and regional level, communities of practice and trajectory-development efforts. These mandated structures supported knowledge exchange and contributed to the recognition of interdependencies, distribution of leadership and development of mutual understanding and trust. Shared motivation benefitted from a vision of patient-centred care but was hindered by top-down communication vehicles that did not allow regional priorities to filter upwards to central level. Between care providers in different settings, trust and candidacy were identified as mechanisms important to shared motivation, though network actions did not sufficiently support trust across care settings, or even between members of the same profession. Candidacy issues hindered family physician participation in cancer network structures that mirrored ongoing difficulties to including them in cancer care practice. Institutional arrangements were important drivers of capacity for joint action in the network. Common indicators were recognized as important to generating efforts towards common goals; however, questions around their validity reduced their contribution to capacities for joint action. Conclusions Despite favorable starting conditions from the national cancer program and its central leadership promoting collaborative governance, tensions that emerge through the pursuit of network integration limit the transition to a more collaborative practice. Taking the time to work out these tensions as integration proceeds in waves appears essential to arrive at a governance model that is appropriate and acceptable for all network members.
Autism disproportionality in racially and ethnically minoritized and girl students in schools
Authors: Beckman Parker S , Brunson McClain Maryellen , Harris Bryn , Brownell Alexa , Beauchesne Britany M , Davis Gwendolyn , Bera Jac’lyn , Shahid Rabbiya 
Published: November 2024

Special education services are crucial for enhancing outcomes and well-being among autistic students. Unfortunately, many racially and ethnically minoritized and girl autistic youth face challenges in timely and accurate identification. National-level data reveal autism prevalence rates differ across student gender, race, and ethnicity hindering access to services and appropriate education. As research focusing on autism disproportionality in schools is limited, we investigate autism identification disparities specific to racially and ethnically minoritized and girl students at the national and state levels in schools. State-level data from the 2019–2020 academic year were obtained from the United States Department of Education and analyzed to assess prevalence rate, relative risk, and systemic-level predictors of autism identification disparities. Girls were under-identified with autism in schools compared to their boy peers. The disproportionality risk of racially and ethnically minoritized students compared to White students had decreased in reference to prior reports, with the least improvement for Latine students. School locale proved significant in predicting the risk of autism identification for girl and Latine students. These findings can inform policy change, raise the collective consciousness, and encourage practitioners to seek out continued education regarding autism identification and girl students to reduce or eliminate these disparities. Lay abstract Special education services are important for helping autistic students succeed, but many racially and ethnically minoritized and girl students face difficulties in getting support because they are not identified appropriately in schools. This study looks at the identification of autism in racially and ethnically minoritized and girl students across schools in the United States during the 2019–2020 school year. We found that girls are less likely to be identified compared to boys, which means they might not get the help they need. The gap between racially and ethnically minoritized students and White students in autism identification has improved slightly, but Latinx students still face challenges. We also found that where students live (their locale) affects their chances of being identified, especially for girls and Latinx students. These findings show that there are disparities in school autism identification, and understanding them can help policymakers, educators, and communities make changes to ensure all autistic students get the support they need.
Positioning Sensor Data Mining and Correlation Analysis Based on Multi-mode Radio Frequency Identification
Authors: Zhao Min 
Published: November 2024

Real-time positioning and sensor data mining are critical for various Internet of things (IoT) applications, but current approaches face challenges such as limited accuracy, high cost, and energy inefficiency. This paper proposes a novel fusion intelligent structure that combines radio frequency identification (RFID) technology and wireless sensor networks (WSN) to enable accurate and efficient positioning and data mining. The proposed method consists of two key components: an energy heterogeneity strategy for optimizing network energy consumption, and a data association feature analysis technique for mining sensor data. The results demonstrated that the proposed approach achieved superior positioning accuracy compared to other algorithms, with an average error of less than 0.300 under various conditions. The data detection accuracy was also high, with a maximum false detection rate of 3%. Furthermore, the proposed energy heterogeneity strategy significantly improved network energy utilization and stability. Real-world scenario testing validated the practicality of the proposed approach, with an average positioning error of less than 0.500 meters. These results validate the effectiveness of the proposed RFID-WSN fusion structure for real-time positioning and sensor data mining, providing a promising solution for IoT applications.
Everolimus treatment in patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative advanced breast cancer and a predictive model for its efficacy: a multicenter real-world study
Authors: Tan Yujing , Peng Zexi , Jiang Hanfang , Ma Fei , Wang Jiayu , Zhang Pin , Li Qing , Tian Xinzhu , Han Yuhang , Ji Danyang , Xu Binghe , Zhao Weihong , Fan Ying 
Published: November 2024

Background:Everolimus is beneficial for patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2−) advanced breast cancer (ABC). However, some patients developed drug resistance and the well-established predictor for everolimus efficacy was limited.Objectives:The study was designed to evaluate the efficacy of everolimus in different treatment lines and identify several clinicopathological markers to estimate everolimus efficacy in patients with HR+/HER2− ABC.Design:This was a retrospective and multicenter study.Methods:Between 2014 and 2022, more than 2000 patients with tumors who received everolimus were collected from multiple cancer centers in China (National Cancer Center, Chinese PLA General Hospital, Peking University Cancer Hospital & Institute). A training cohort and two validation cohorts were developed.Results:The training cohort included 338 patients. The median progression-free survival (PFS) for everolimus was 5.6 months, with an objective response rate of 25.1% and a clinical benefit rate of 54.4%. PFS was significantly worse from first-line (1L) to second-line (2L) to third-line (3L), with PFS1Lfor 13.5 months, PFS2Lfor 6.1 months, and PFS3Lfor 4.1 months ( p = 2.9e−6, hazard ratio (HR) = 0.70, 95% confidence interval (CI) = 0.61–0.82). The clinicopathological characteristics, including post-1L everolimus treatment, Ki67 index of more than 40%, more than two metastatic sites at first recurrence, and receiving adjuvant chemotherapy, were independent risk factors for PFS. A predictive model for everolimus efficacy was established using these four factors. In the low-risk group, patients achieved a median PFS of 12.6 months, significantly longer compared to 2.7 months for those in the high-risk group ( p = 2.4e−64, HR = 9.41, 95% CI = 7.05–12.56). The area under the curve was 0.96, 0.95, and 0.94 for 6-month, 1-year, and 3-year PFS, respectively. Internal validation cohort (PFS 18.4 vs 3.1 months, p = 3.6e−11, HR = 3.78, 95% CI = 2.49–5.74) and external validation cohort (PFS 13.5 vs 3.1 months, p = 2.9e−10, HR = 11.53, 95% CI = 4.68–28.37) confirmed its power for estimating clinical benefits of everolimus.Conclusion:A predictive model was successfully established to predict survival outcomes for everolimus in patients with HR+/HER2− ABC, which may provide references for the management of everolimus in Chinese patients with HR+/HER2− ABC.
Role of repeat transurethral resection in no-muscle-invasive bladder tumour: an umbrella review
Authors: Yu Qing-Xin , Wu Rui-Cheng , Tuo Zhou-Ting , Zhu Wei-Zhen , Wang Jie , Ye Xing , Yoo Koo Han , Wei Wu-Ran , Feng De-Chao , Li Deng-Xiong 
Published: November 2024

Background: Repeat transurethral resection of bladder tumour (reTURB) is a conventional treatment for non-muscle-invasive bladder cancer (NMIBC) to enhance prognosis. However, the necessity of reTURB in NMIBC remains controversial owing to upstaging of treatments and new evidence. Objectives: We performed an umbrella review to determine the need for reTURB in patients with NMIBC. Design: We extracted data from meta-analyses that were screened out after a systematic search of PubMed, Embase, the Web of Science and the Cochrane Database of Systematic Reviews. Methods: Risk of Bias in Systematic Reviews and the Grading of Recommendations, Assessment, Development and Evaluation tools were used to assess the quality of each included meta-analysis and outcomes. Results: Our study included seven meta-analyses. Two studies assessed the efficiency of reTURB in patients who underwent en bloc resection of bladder tumours (ERBT). Patients who underwent ERBT reported low residual tumour and upstaging rates of 5.9% and 0.3%, respectively. Conversely, patients who underwent conventional transurethral resection for bladder cancer (cTURB) had high residual tumour rates. Patients who underwent cTURB and reTURB had significantly improved 1-year recurrence-free survival (RFS) compared to those who underwent initial cTURB alone. In terms of progression-free survival (PFS), a meta-analysis reported that patients who underwent cTURB and reTURB had significantly improved PFS compared with those who underwent initial cTURB alone. In the subgroup analyses of ERBT, reTURB did not affect the RFS and PFS of patients who received ERBT. Currently, only a limited number of randomised clinical trials have evaluated reTURB, and various factors have influenced its efficacy. Conclusion: There was significant variation in survival outcomes among patients undergoing reTURB. The necessity and efficacy of reTURB depend on numerous factors, such as surgical approach, equipment and medication usage. Patients eligible for ERBT may constitute a group that does not require reTURB. Further clinical trials are required to validate these findings. Registration: This umbrella review was registered with the International Prospective Register of Systematic Reviews (CRD42023439078).
The effect of vitamin D on the speed and quality of pediatric fracture healing
Authors: Hendrych Jan , Havránek Petr , Bayer Milan , Čepelík Martin , Pešl Tomáš 
Published: November 2024

Purpose: To evaluate the effect of vitamin D on the speed and quality of pediatric fracture healing. Methods: A 4-year prospective study of healthy children with shaft fractures of the forearm bones (treated with minimally invasive osteosynthesis) or femur (treated by traction or by minimally invasive osteosynthesis). All children had their vitamin D levels examined four times—at the time of the injury, 1, 3, and 5 months after the injury. Also, all children underwent radiograph follow-ups (same time as blood tests) to evaluate fracture healing. Children were, in the beginning, blindly divided into two similarly sized groups—one group was orally administered cholecalciferol throughout the follow-up, the second group was not, and we compared those groups. Results: Altogether, 63 children were included in the study—36 supplemented and 27 non-supplemented. In supplemented children, the vitamin D levels increased statistically significantly during the follow-up period, in contrast to the non-supplemented group. The fracture healing on radiographs was also statistically significantly faster and better in the supplemented group. When we divided children according to fracture type, we observed statistically significantly better fracture healing in children with forearm fractures in the supplemented group for the whole study period. In children with femoral fractures, the healing in the supplemented group was statistically significantly better after 3 months; however, after 1 and 5 months, the difference was not statistically significant. Conclusions: Based on our results, we recommend vitamin D testing and administration for children treated for forearm and femoral fractures. Level of evidence: Level I.