bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amplified Cascade Catalysis for RAFT Polymerization
Authors: Zhao Yue , Zhang Shudi , An Zesheng 
Published: November 2024

AbstractWe report a conceptually new amplified cascade catalysis that converts oxygen to hydroxyl radical for controlled RAFT polymerization. This catalysis consists of two sequential reactions, deoxygenation catalyzed by glucose oxidase and Fenton reaction catalyzed by ferrocene. The two catalysts can communicate with each other, leading to ferrocene recycling and hence amplification in radical generation. Ferrocene recycling was confirmed by UV/Vis spectroscopy, molecular docking simulation, electron paramagnetic resonance spectroscopy, as well as polymerization studies. This catalysis was applied to RAFT polymerization of various monomers, yielding well‐defined homopolymers and diblock copolymers with controlled molecular weights and low dispersities. Poly(N,N‐dimethyl acrylamide) with molecular weight over 1 million g mol−1 was also successfully synthesized under ambient conditions. Ferrocene‐functionalized microspheres were prepared and used as recyclable Fenton catalyst for five consecutive polymerizations with minimal declination in monomer conversion, which further improved the ecofriendly character of this polymerization methodology.
Examining the Impact of 3D Multi‐Arm Small Molecules on PM6 : Y6 Blend Reveals the Key Requirements for Their Electronic Properties
Authors: Huang Yuehao , Yu Ziwen , Yin Ailing , Han Gao‐Feng , Lang Xing‐You , Brédas Jean‐Luc , Wang Tonghui , Jiang Qing 
Published: November 2024

AbstractWhile the emergence of PM6 : Y6 active layer re‐energized the organic photovoltaic community, excessive aggregation of Y6 molecules induced by their strong intermolecular interactions has limited the performance of PM6 : Y6‐based organic solar cells (OSCs). Adding 3D multi‐arm small‐molecule acceptors is an effective strategy to inhibit such aggregation. However, to maximize OSC efficiency, these molecules should also contribute to the electronic processes. Here, by taking a benzotriazole‐based 3D four‐arm small molecule (i.e., SF‐BTA1) as representative example, we combine molecular dynamics simulations and density functional theory calculations to examine the molecular‐scale impact of 3D multi‐arm small molecules on morphological characteristics (especially at the nanoscale) and electronic properties of PM6 : Y6 blends. By considering the intermolecular packing distances, density, and patterns among PM6, Y6, and SF‐BTA1 components, exciton transfer rates from SF‐BTA1 to Y6 or PM6, charge transfer rates from Y6 or PM6 to SF‐BTA1, electron/hole transfer rates among adjacent Y6/PM6 pairs, and radiative and non‐radiative recombination processes, we draw a comprehensive picture that describes how 3D multi‐arm small molecules improve morphological and electronic properties of PM6 : Y6 blends and thus the OSC efficiency. Furthermore, successful rationalization of these aspects allows us to point out key requirements regarding the electronic properties of 3D multi‐arm small molecules.
Single Crystalline, Non‐Stoichiometric Hydrogen‐Bonded Organic Frameworks Showing Versatile Fluorescence Depending on Composition Ratios and Distributions
Authors: Hashimoto Taito , Hoz Tomás Mario de la , Oketani Ryusei , Cohen Boiko , Naruoka Miki , Tohnai Norimitsu , Douhal Abderrazzak , Hisaki Ichiro 
Published: November 2024

AbstractHydrogen‐bonded organic frameworks (HOFs) composed of multicomponent molecules in a non‐stoichiometric composition have drawn great interest due to their tunable properties. However, the photobehavior of the single crystals of such mixed HOFs has not been explored. Here, we report on the synthesis, characterization and photobehavior of single crystalline non‐stoichiometric HOFs (NS‐HOFs). NS‐HOFs (BTNT‐1) with various composition ratios were successfully obtained as single crystals from two analogue tetratopic carboxylic acids, possessing naphthalene and benzothiadiazole cores (NTTA and BTTA, respectively). The heterogeneous distribution of the components was thoroughly confirmed by time‐resolved fluorescence microscopy and local crystallographic analysis using focused synchrotron X‐ray radiation. The versatile fluorescence of BTNT‐1 behavior depends on the composition ratio and distribution of the component in the single crystals. We observed not only fluorescence bands with various colors such as purple, blue, green and white, depending on the composition ratios, but also different emission bands from a single crystal. We provide details on their emission lifetimes following the composition, emission color and targeted region on the crystal. This work is the first example of single crystal studies applied to organic porous co‐crystals and demonstrates unique and versatile optical properties of carboxylic acid‐based NS‐HOFs. The results provide a concept of creating functional mixed porous materials capable of different and tunable optical properties.
Strengthening an OR Nurse Residency Program: Enhancing Education and Achieving Accreditation
Authors: Weatherly Patricia , Small Nicole , Fencl Jennifer L. (Zinn) 
Published: November 2024

ABSTRACTThis article discusses the implementation and enhancement of an OR nurse residency program at a health care system in North Carolina. Recognizing the unique challenges and skills required in perioperative nursing, program coordinators aimed to support new nurses transitioning into the OR setting. Key enhancements included incorporating AORN's Periop 101: A Core Curriculum to provide consistent, evidence‐based perioperative education and pursuing accreditation through the Commission on Collegiate Nursing Education to ensure the highest standards of excellence. The program also emphasizes simulation training, preceptor guidance, and continuous feedback to increase residents’ proficiency and confidence. The integration of Periop 101 has led to successful outcomes, including high pass rates on comprehensive exams and residents achieving the Certified Foundational Perioperative Nurse credential offered by the Competency & Credentialing Institute. This article highlights the importance of structured education, leadership involvement, and continuous improvement to develop competent and skilled OR nurses.
Quantitative Comparison of ROV and Diver‐Based Photogrammetry to Reconstruct Maerl Bed Ecosystems
Authors: Paterson Iona L. R. , Dawson Kathryn E. , Mogg Andrew O. M. , Sayer Martin D. J. , Burdett Heidi L. 
Published: November 2024

ABSTRACTIn a time of ever‐increasing pressure on the coastal ocean and rising costs, the development of effective and efficient methods for assessing the health of marine ecosystems is becoming essential for continued conservation efforts. Taking advantage of technologies such as remotely operated vehicles (ROVs) may be a way of achieving this, but a quantitative check on the quality of ROV‐derived data is necessary. Here, using coralline algae reefs (maerl beds) as a model habitat, we compared 3D seabed reconstructions obtained from structure‐from‐motion photogrammetry surveys from diver‐held and ROV‐mounted camera systems. We found that both approaches achieved satisfactory alignment and mm‐scale resolution, allowing small‐scale features and individual organisms in the maerl bed to be resolved. The higher quality camera system available to divers resulted in generally lower modelling errors, but the spatial extent of surveys was highly restricted. In contrast, although associated with a slightly higher error, we show that much larger areas can be surveys by ROVs—we reconstructed 11,285 m2 of seabed in just 400 min of ROV deployment time. Moving forward, we recommend that a hybrid survey approach is adopted: utilising ROV surveys for large‐scale monitoring and diver surveys for higher detail insights that are informative for areas with highly complex and fine‐scale morphologies (like coralline algae reefs). Here, even small changes in complexity can be indicative of habitat change, and associated species can be small in size so multiscale visual assessment is beneficial.
Assessing the causal association between celiac disease and autism spectrum disorder: A two‐sample Mendelian randomization approach
Authors: Fatoba Abiodun , Simpson Claire 
Published: November 2024

AbstractThe association between celiac disease (CD) and autism spectrum disorder (ASD) remains inconclusive. Reports from different observational studies have become controversial, necessitating exploration of the causal relationship between CD and ASD. To assess true causality, this study used a two‐sample Mendelian randomization (MR) analysis to determine the causal association between CD and ASD. Summary‐level data from a genome‐wide association study (GWAS) of the European population were used to select instrument variables (IVs) at genome‐wide significance (p < 5 × 10−8). The strength of IVs was also evaluated with F‐statistics. The inverse variance weighted method (IVW) was the primary MR analysis, supported by other MR tests such as the weighted median method and weighted mode. The presence of horizontal pleiotropy was tested with MR‐Egger and MR‐PRESSO while other sensitivity analyses such as heterogeneity, leave‐one‐out analysis, and scatterplot were used to assess the validity of our MR results. Our study did not show an association between CD and ASD (OR, 0.994; 95% CI, 0.935–1.057; p = 0.859). There was also no evidence of horizontal pleiotropy (MR‐Egger intercept = 0.015; p‐value = 0.223) and heterogeneity (Q = 14.029; p‐value = 0.051). These results were also complemented by the leave‐one‐out analyses, forest plot, and scatter plot, which showed that none of the SNPs influenced the result. The result of this study shows that CD is not causally associated with ASD.
Clinical Presentation and Long‐Term Survival Outcomes of Patients With Monoclonal Gammopathy of Renal Significance (MGRS): A Multicenter Retrospective Study
Authors: Mancuso K. , Mina R. , Rocchi S. , Antonioli E. , Petrucci M. T. , Fazio F. , Gozzetti A. , Salvini M. , Cartia C. S. , Bertuglia G. , Patriarca F. , Dalla Palma A. B. , Barbato S. , De Cicco G. , Bigi F. , Favero E. , Tacchetti P. , Pantani L. , Rizzello I. , Puppi M. , Talarico M. , Solli V. , Kanapari A. , Cavo M. , Zamagni E. 
Published: November 2024

ABSTRACTIntroductionMGRS are new rare clinical entities, whose recognition and optimal management is evolving.MethodsTo implement real‐life data, we retrospectively analysed a multicentre cohort of 60 patients with renal biopsy‐proven MGRS receiving mainly novel treatments (between 2006 and 2021) in eight Italian centres. Based on renal biopsy, patients were divided into two subgroups: AL amyloidosis (70%, n = 42) and other‐MGRS (30%, n = 18).ResultsBaseline characteristics follow typical manifestations of MGRS disorders in terms of small clonal burden, laboratory and clinical features. More patients with AL amyloidosis had monotypic lambda light‐chain disease, estimated glomerular filtration rate (eGFR) ≥ 60 mL/min and nephrotic proteinuria than other‐MGRS group. The most widely used drug was bortezomib, and about one‐third of patients underwent ASCT. Overall response rate was 86% with no differences in the two subgroups. However, high‐quality hematologic responses ≥very good partial response (VGPR) were greater in AL amyloidosis than in other‐MGRS group (67% vs 28%, p = 0.015). The depth of haematological response influenced renal response, obtained in 32 (59%) of evaluable patients, similarly in the subgroups. Indeed, 75% patients with ≥ VGPR (p = 0.049) and none with stable disease (p ≤ 0.001) obtained a renal response. No association between renal response and histotypes (p = 0.9) or type of first‐line therapy (p = 0.3) was found. At a median follow‐up of 54.4 months (IQR 24.8–102.8), median progression‐free survival (PFS) was 100.1 months (95% CI 34.9–NR), and median overall survival not reached (95% CI 129.8–NR). No significant difference emerged between the two groups in terms of survival outcomes. Achieving ≥ VGPR was confirmed as the main independent predictor of prolonged PFS in the general population (HR = 0.29, p = 0.023) and AL amyloidosis group (HR 0.23; p = 0.023). Preserved renal function at diagnosis was predictive of improved PFS in the AL amyloidosis group (eGFR ≥ 60 mL/min: HR = 0.003; p = 0.018; eGFR 30–60 mL/min: HR = 0.04, p = 0.046).ConclusionFurther research is warranted to develop standardised response criteria and treatment strategies to improve MGRS management.
Fusobacterium nucleatum Abundance is Associated with Cachexia in Colorectal Cancer Patients: The ColoCare Study
Authors: Ilozumba Mmadili N. , Lin Tengda , Hardikar Sheetal , Byrd Doratha A. , Round June L. , Stephens W. Zac , Holowatyj Andreana N. , Warby Christy A. , Damerell Victoria , Li Christopher I. , Figueiredo Jane C. , Toriola Adetunji T. , Shibata David , Fillmore Gary C. , Pickron Bartley , Siegel Erin M. , Kahlert Christoph , Florou Vaia , Gigic Biljana , Ose Jennifer , Ulrich Cornelia M. 
Published: November 2024

ABSTRACTBackgroundCachexia accounts for about 20% of all cancer‐related deaths and indicates poor prognosis. The impact of Fusobacterium nucleatum (Fn), a microbial risk factor for colorectal cancer (CRC), on the development of cachexia in CRC has not been established.MethodsWe evaluated the association between Fn abundance in pre‐surgical stool samples and onset of cachexia at 6 months post‐surgery in n = 87 patients with stages I–III CRC in the ColoCare Study.ResultsHigh fecal Fn abundance compared to negative/low fecal Fn abundance was associated with 4‐fold increased risk of cachexia onset at 6 months post‐surgery (OR = 4.82, 95% CI = 1.15, 20.10, p = 0.03).ConclusionOur findings suggest that high fecal Fn abundance was associated with an increased risk of cachexia at 6 months post‐surgery in CRC patients. This is the first study to link Fn abundance with cachexia in CRC patients, offering novel insights into biological mechanisms and potential management of cancer cachexia. Due to the small sample size, our results should be interpreted with caution. Future studies with larger sample sizes are needed to validate these findings.
Autoinhibition in (Bio)Chemistry: Identification and Mechanistic Classification
Authors: Horváth Attila K. , Gao Qingyu 
Published: November 2024

AbstractAutoinhibition is a frequently invoked self‐regulatory mechanism involved in various cellular processes to interpret clearly how these cells may control their complex functioning. This type of temporal behavior generally results in self‐retardation or even in complete shuts down of the undesired reactions to occur meaning that the rate of a certain biochemical reaction is partially or completely retarded. Precise characterization and classification of a complex system where deceleration of the reaction rate is found, however, requires special circumspection to avoid false interpretation. Hereby, it was clearly demonstrated that the retardation effect of an inhibitor is unexpectedly often misidentified as autoinhibition, especially in complex biochemical enzymatic systems. It prompted us to clarify unambiguously the difference between inhibition and autoinhibition. The latter kinetic phenomenon is a special type of inhibition where the inhibitor forms by the result of a chemical or biochemical event exerting the self‐decelerating effect on the rate of its own formation resulting thus in significantly different temporal patterns compared to the ones observed in the case of simple inhibitions. Kinetic activity of autoinhibitor towards the species involved in the given system allowed us to classify direct, indirect and dual autoinhibitions to be supported by real chemical examples.
Debris Embolization to the Lung After a Bioprosthetic (Mitroflow®) Valve Fracture
Authors: Nogales Eliú D. P. , Cabrera Francisco J. , del Mar Ávila Maria , Reyes Elisabet V. 
Published: November 2024

ABSTRACTThis case report shows a valve in valve procedure in pulmonary position of a 19‐year‐old male with a repaired Tetralogy of Fallot. After initial correction, a Mitroflow 23 mm bioprosthetic valve was implanted in pulmonary position. Nine years later severe degeneration of the valve occurred. He underwent percutaneous Melody valve implantation after balloon valvuloplasty and controlled rupture of the Mitroflow prosthesis. A fragment from the fractured prosthesis migrated to the right pulmonary artery without clinical consequences. Postimplantation echocardiography revealed improved hemodynamics. Percutaneous valve implantation on a degenerated bioprosthetic valve is a rising technique with some concerns such as prosthetic‐patient mismatch and potential debris embolization. This report emphasizes the successful use of balloon fracture to achieve larger diameters for the newly implanted valve and notes that debris embolization does not appear to have a clinical impact.
Feature Variable Selection for Near‐Infrared Spectroscopy Based on Simulated Annealing Bee Colony Algorithm
Authors: Shi Jianfei , Tong Baihong , Liu Jinming , Chen Zhengguang , Li Pengfei , Tan Chong 
Published: November 2024

ABSTRACTVariable selection is an effective method to enhance the modeling performance of near‐infrared spectroscopy. Given the promising application prospects of intelligent optimization algorithms in spectral feature variable selection, this article combines the artificial bee colony algorithm with the simulated annealing algorithm to construct a simulated annealing bee colony algorithm (SABC). To explore the feasibility of SABC for spectral variable selection, SABC was applied to construct a partial least squares spectral quantitative detection model for corn stover cellulose and soil organic matter contents. The modeling performance was compared with that of the full spectrum, genetic algorithm, simulated annealing algorithm, and artificial bee colony algorithm; it was found that the model regression precision established by SABC was the best. For the cellulose and organic matter content detection models, the coefficients of determination of the validation set were 0.9433 and 0.9853, with the relative root mean squared error of 1.7901% and 0.8011%, and the residual prediction deviation of 4.1741 and 8.3931, respectively, which could meet the corresponding actual detection needs. SABC adopted the strategy of multiple runs to select the repeated wavelength variables, effectively reduced variable dimensions and model complexity, improved the prediction performance of the regression model, and provided a new approach for building a high‐performance near‐infrared spectroscopy (NIRS) quantitative calibration model.
π‐Spacer Engineering: Driving Near‐infrared Aggregation Induced‐emission and Mechanofluorochromism in Carbazole‐biscyanostilbenes
Authors: Afrin A , Swamy P Chinna Ayya 
Published: November 2024

AbstractIn this study, we report the design and synthesis of two novel carbazole‐based bis‐cyanostilbenes incorporating phenyl and thiophene π‐spacer units to investigate their distinct impacts on photophysical properties. Notably, the thiophene‐based derivative exhibits remarkable far‐red/near‐infrared (NIR) solid‐state emission, with an emission peak at 732 nm, which shifts to 750 nm upon mechanical grinding, demonstrating pronounced mechanochromic fluorescence in the NIR region. Although its quantum yield is moderate, the ability to modulate its emission through mechanical stimuli opens exciting opportunities for stimuli‐responsive NIR applications. Conversely, the phenyl‐based analogue shows excellent solid‐state emission at 596 nm, achieving significantly higher quantum yields, due to suppressing π‐π interactions. Both compounds also exhibit strong AIE, with the thiophene system emitting at 730 nm and the phenyl‐based analogue at 580 nm in the aggregate state. In addition to their optical properties, both derivatives demonstrate remarkable thermal stability and reversible MFC. These intriguing behaviors highlight the critical role of π‐spacer engineering in fine‐tuning solid‐state emission, enhancing stimuli‐responsive capabilities, and ensuring robust thermal performance. Overall, our findings provide valuable insights into the design of next‐generation NIR‐emissive materials, with promising potential for advancing applications in optoelectronics, bioimaging, and smart sensing technologies.
Novel Easy‐to‐Synthesize Hydrazine Multi‐channel Detection and Adsorption Materials
Authors: Liu Juan , Zhao Hou‐Yi , Liu Zi‐Wen , Chen Peng‐Yu , Tao Shao‐Ping , Wu Lan , Li Gui‐Hua , Cui Lu‐Juan , Lin Qi 
Published: November 2024

Comprehensive SummaryHydrazine hydrate (DH) is a widely used chemical agent, but it is highly toxic. Thus, the development of low‐cost and easy‐to‐prepare materials for the detection and adsorption of DH is very significant. Herein, a novel and easy‐to‐prepare supramolecular smart material based on bisquinoline‐functionalized naphthalene diimide (DQ8) has been designed and synthesized. In the DQ8, the synergistic effect between quinoline and naphthalene diimide groups has been employed to improve the selectivity and sensitivity for binding of DH. The DQ8‐based crystalline porous material (DQ8‐CPM) can simultaneously detect and adsorb DH and produce noticeable fluorescence color changes after adsorption of DH vapor. More significantly, the DQ8‐CPM shows nice recycling performance on DH detection and adsorption. Meanwhile, a smart gel based on DQ8 (DQ8‐G) shows multi‐channel response for DH through color, fluorescence, and state changes. The DQ8 shows high selectivity and sensitivity for DH. The detection limit of DQ8 for DH is 8.6 × 10–7 mol/L. According to the investigation of the DH binding and response mechanism, the synergistic effect between quinoline and naphthalene diimide groups plays an important role in the DH response process. It's a simple and feasible way to develop materials for detection and adsorption of DH through synergistic effects.
Beyond the Surface: A Unique Presentation of Acute Promyelocytic Leukemia as Idiopathic Intracranial Hypertension: A Case Report
Authors: Mirhosseini Amirhossein , Shariat Mirmassoud , Ebrahimi Mandana , Saeedy Negar , Nouri Behnaz 
Published: November 2024

ABSTRACTBackgroundAcute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia defined by a fusion gene transcript called PML::RARA. Pseudotumor cerebri (PTC) is characterized by elevated intracranial pressure (ICP) and presents with pulsatile tinnitus, headaches, and visual disturbances. Pseudotumor cerebri has been observed in some patients undergoing long‐term ATRA therapy. While both APL and PTC have been individually described in the literature, their coexistence in a single patient, especially with PTC being the first clinical manifestation of APL, is an exceptionally rare occurrence, making this case particularly unique and warranting further investigation.Case PresentationWe present the case of a 30‐year‐old woman who initially presented with symptoms suggestive of PTC. The diagnosis of PTC was confirmed through a lumbar puncture. However, further investigations revealed that the patient had APL, which is typically sensitive to treatment with all‐trans‐retinoic acid (ATRA). To our knowledge, the association between APL and PTC as the first clinical manifestation of APL in adult patients has not been previously reported in the literature, further highlighting the exceptional rarity of this case.ConclusionsThis case underscores the importance of considering underlying systemic diseases in patients presenting with PTC, as it may represent an exceptionally rare initial manifestation of a rare underlying malignancy such as APL. The coexistence of APL and PTC in this patient highlights the need for a comprehensive evaluation and management approach to promptly diagnose and treat coexisting conditions. Healthcare providers must be aware of this association and consider the possibility of APL when evaluating patients with PTC symptoms. Such awareness can prompt timely recognition and appropriate management, thereby improving patient outcomes and preventing potential delays in diagnosis and treatment.