bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oleoylethanolamide: A novel pharmaceutical agent in the management of obesity‐an updated review
Authors: Laleh Payahoo , Yaser Khajebishak , Alireza Ostadrahimi 
Published: December 2018

AbstractObesity as a multifactorial disorder has been shown a dramatically growing trend recently. Besides genetic and environmental factors, dysregulation of the endocannabinoid system tone is involved in the pathogenesis of obesity. This study reviewed the potential efficacy of Oleoylethanolamide (OEA) as an endocannabinoid‐like compound in the energy homeostasis and appetite control in people with obesity. OEA as a lipid mediator and bioactive endogenous ethanolamide fatty acid is structurally similar to the endocannabinoid system compounds; nevertheless, it is unable to induce to the cannabinoid receptors. Unlike endocannabinoids, OEA negatively acts on the food intake and suppress appetite via various mechanisms. Indeed, OEA as a ligand of PPAR‐α, GPR‐119, and TRPV1 receptors participates in the regulation of energy intake and energy expenditure, feeding behavior, and weight gain control. OEA delays meal initiation, reduces meal size, and increases intervals between meals. Considering side effects of some approaches used for the management of obesity such as antiobesity drugs and surgery as well as based on sufficient evidence about the protective effects of OEA in the improvement of common abnormalities in people with obese, its supplementation as a novel efficient and FDA approved pharmaceutical agent can be recommended.
GRIM‐19 repressed hypoxia‐induced invasion and EMT of colorectal cancer by repressing autophagy through inactivation of STAT3/HIF‐1α signaling axis
Authors: Zhang Juan , Chu Dake , Kawamura Takuji , Tanaka Kiyohito , He Shuixiang 
Published: December 2018

AbstractHypoxia leads to cancer progression and promotes the metastatic potential of cancer cells. Thereby, the aim of the present study was to investigate the detailed effects of gene associated with retinoid‐interferon‐induced mortality‐19 (GRIM‐19) in colorectal cancer (CRC) cell lines under hypoxia conditions and explore the potential molecular mechanisms. Here, we observed that GRIM‐19 expression was downregulated in several CRC cell lines as well as in HCT116 and Caco‐2 cells under a hypoxic microenvironment. Additionally, the introduction of GRIM‐19 obviously suppressed cell invasive ability and epithelial–mesenchymal transition (EMT) through modulating EMT markers as reflected by the upregulation of E‐cadherin along with the downregulation of vimentin and N‐cadherin under hypoxic conditions. Moreover, the addition of GRIM‐19 repressed hypoxia‐induced autophagy through modulating autophagy associated proteins as reflected by the downregulation of LC3‐II/LC3‐I ratio and Beclin‐1 expression, as well as the increased of p62 expression. Interestingly, overexpression of GRIM‐19 markedly ameliorated the accumulation of HIF‐1α triggered by hypoxia accompanied by an inhibition of vascular endothelial growth factor (VEGF) production and phospho‐signal transducer and activator of transcription 3 (p‐STAT3) expression. Further data demonstrated that GRIM‐19 have a negative feedback effect on the expression of HIF‐1α. Mechanistically, re‐expression of HIF‐1α completely reversed the inhibitory effects of GRIM‐19 on hypoxia‐induced invasion and EMT. Taken all data together, our findings established that GRIM‐19 suppresses hypoxia‐triggered invasion and EMT by inhibiting hypoxia‐induced autophagy through inactivation HIF‐1α/STAT3 signaling pathway, indicating that GRIM‐19 may serve as a potential predictive factor and therapeutic target for CRC treatment.
T‐bet transcription factor in cardiovascular disease: Attenuation or inflammation factor?
Authors: Haybar Habib , Rezaeeyan Hadi , Shahjahani Mohammad , Shirzad Reza , Saki Najmaldin 
Published: December 2018

AbstractT‐bet is a major transcription factor increasing inflammatory responses in the immune system. Recently, it has been shown that this factor leads to inflammation in cardiovascular disease (CVD). In this study, we examine the dual role of T‐bet in inducing and suppressing inflammatory reactions as well as angiogenesis induction due to inflammatory cytokines in CVD. Relevant literature was identified by a Pubmed search (1992–2018) of English‐language papers using the terms “T‐bet,” “Cardiovascular disease,” “Immune response,” and “Angiogenesis.” Although T‐bet causes differentiation of Th1 cells and activation of immune cells such as NK and DC, it suppresses inflammatory responses and replaces damaged vessels with new ones by activating regulatory T‐cells and stimulating angiogenesis. It can be stated that T‐bet acts as double‐edged sword. Therefore, the identification of pathways that can increase the function of T‐bet in activating Tregs and inducing angiogenesis might be used as a new therapeutic option in future investigations.
Combined treatment with systemic resveratrol and resveratrol preconditioned mesenchymal stem cells, maximizes antifibrotic action in diabetic cardiomyopathy
Authors: ShamsEldeen Asmaa Mohammed , Ashour Hend , Shoukry Heba Samy , Fadel Mostafa , Kamar Samaa Samir , Aabdelbaset Marwan , Rashed Laila Ahmed , Ammar Hania Ibrahim 
Published: December 2018

AbstractWnt/β‐catenin signaling pathway plays a crucial role in diabetic cardiomyopathy (DCM), thus we aimed at investigating the effect of one therapeutic approach with resveratrol (RSV) given systemically and combined treatment of RSV with mesenchymal stem cells (MSCs) that was either RSV‐preconditioned or not on Wnt/β‐catenin signaling pathway in streptozotocin‐induced DCM, and to evaluate effects of RSV preconditioning on MSCs therapeutic potential. The rats were divided into control (C, n = 8), diabetic (DM, n = 8), diabetic treated with systemic RSV (DM‐RSV, n = 8), diabetic treated with RSV and nonconditioned MSCs (DM‐RSV‐MSCs, n = 8), diabetic treated with RSV and RSV‐incubated with MSCs (DM‐RSV‐MSCc, n = 8) and diabetic treated with RSV‐conditioned MSCs (DM‐MSCc, n = 8). Echocardiography (Echo) showed significant improvement of cardiac functions in all groups treated with RSV either systemic or added in culture media. Data of ejection fraction (EF%) of DM‐RSV‐MSCc (81.50; interquartile range [IQR], 80.00–83.00) was comparable to both DM‐RSV‐MSCs (77.50; IQR, 71.50–79.00), and DM‐MSCc (71.50; IQR, 70.00–74.50). Histological examination of the left ventricles was performed for all groups. DM group revealed significant myocardial hypertrophy, apoptosis, interstitial fibrosis, and microvascular affection. All treated groups were associated, in variable degrees, with attenuation of cardiac hypertrophy and fibrosis, decreased area% for cardiac immunostaining of secreted frizzled‐related protein (sFRP2) and Wnt/β‐catenin and improvement of the microvasculature. In conclusion, MSCs pretreated with resveratrol for 7 days showed increased 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay, and combined use of RSV (systemically and in culture media) significantly could improve cardiac remodeling capacity of MSCs via attenuation of sFRP2‐mediated fibrosis and the downstream Wnt/β‐catenin pathway.
microRNAs: Key players in virus‐associated hepatocellular carcinoma
Authors: Sadri Nahand Javid , Bokharaei‐Salim Farah , Salmaninejad Arash , Nesaei Abolfazl , Mohajeri Fatemeh , Moshtzan Azadeh , Tabibzadeh Alireza , Karimzadeh Mohammad , Moghoofei Mohsen , Marjani Arezo , Yaghoubi Shoeleh , Keyvani Hossein 
Published: December 2018

AbstractHepatocellular carcinoma (HCC) is known as one of the major health problems worldwide. Pathological analysis indicated that a variety of risk factors including genetical (i.e., alteration of tumor suppressors and oncogenes) and environmental factors (i.e., viruses) are involved in beginning and development of HCC. The understanding of these risk factors could guide scientists and clinicians to design effective therapeutic options in HCC treatment. Various viruses such as hepatitis B virus (HBV) and hepatitis C virus (HCV) via targeting several cellular and molecular pathways involved in HCC pathogenesis. Among various cellular and molecular targets, microRNAs (miRNAs) have appeared as key players in HCC progression. miRNAs are short noncoding RNAs which could play important roles as oncogenes or tumor suppressors in several malignancies such as HCC. Deregulation of many miRNAs (i.e., miR‐222, miR‐25, miR‐92a, miR‐1, let‐7f, and miR‐21) could be associated with different stages of HCC. Besides miRNAs, exosomes are other particles which are involved in HCC pathogenesis via targeting different cargos, such as DNAs, RNAs, miRNAs, and proteins. In this review, we summarize the current knowledge of the role of miRNAs and exosomes as important players in HCC pathogenesis. Moreover, we highlighted HCV‐ and HBV‐related miRNAs which led to HCC progression.
Killian‐Jamieson diverticulum mimicking a thyroid nodule: A case report
Authors: Ota Koshi , Onoe Miyako , Oka Masahiro , Ota Kanna , Taniguchi Kohei , Sakaue Masahide , Takasu Akira 
Published: December 2018

AbstractKillian‐Jamieson diverticulum (KJD) is a rare disease of the cervical esophagus, often misidentified as thyroid nodules on ultrasonography. We performed carotid artery ultrasonography for an asymptomatic 68‐year‐old man. The ultrasound showed an oval nodule with heterogeneous echogenicity surrounded by a multilayered rim in the posterior left thyroid gland. As endoscopy and computed tomography confirmed pharyngoesophageal diverticulum in the anterolateral wall of the esophagus, we reached a final diagnosis of KJD. In cases where a thyroid nodule is detected by ultrasound, physicians should be aware of the possibility of KJD before performing invasive procedures.
The lymph node status and histologic subtypes influenced the effect of postoperative radiotherapy on patients with N2 positive IIIA non–small cell lung cancer
Authors: Yuan Chongze , Tao Xiaoting , Zheng Difan , Pan Yunjian , Ye Ting , Hu Hong , Xiang Jiaqing , Zhang Yawei , Chen Haiquan , Sun Yihua 
Published: December 2018

Background and ObjectiveTo investigate the role of postoperative radiotherapy (PORT) in IIIA‐N2 non–small cell lung cancer (NSCLC) patients and subgroups which derived benefit from PORT.MethodsA total of 576 patients with pathological IIIA‐N2 NSCLC, who underwent complete resection, were identified. Propensity score matching (PSM) methods were used to balance the patients' characteristics between two groups. Overall survival (OS) and relapse‐free survival (RFS) were compared between PORT and non‐PORT patients.ResultsOn multivariable analysis, improved OS remained correlated with younger age, single N2 station involvement, less positive lymph nodes, and chemotherapy. After PSM, 121 PROT patients and 242 non‐PORT patients were matched. PORT was not associated improved patients' OS (P = 0.735) or RFS (
P = 0.483). For patients who underwent postoperative chemotherapy (POCT), PORT could improve OS in single N2 station involved patients (HR: 0.572, 95%CI: 0.312 to 1.05,
P = 0.040). Patients with papillary predominant adenocarcinoma also benefited from PORT with an increase in OS (HR: 0.350, 95%CI: 0.126 to 0.972,
P = 0.033).ConclusionsFor patients with completely resected IIIA‐N2 NSCLC, mediastinal lymph node metastasis and histologic subtypes could influence the effect of PORT. Single N2 station involvement and papillary predominant subtype were predictors of benefit from PORT.
Genetic variants in COL11A2 of lumbar disk degeneration among Chinese Han population
Authors: Yang Xuejun , Jia Haiyu , Xing Wenhua , Li Feng , Li Manglai , Sun Ke , Zhu Yong 
Published: December 2018

AbstractBackgroundLumbar disk disease (LDD) is a common musculoskeletal disorder. Several predisposing genetic and environmental risk factors have been established for symptomatic LDD.MethodsWe conducted a case–control association study to investigate the role of the COL11A2 gene in LDD. Genotyping of 384 Chinese Han LDD patients and 384 Chinese Han controls was made for six single‐nucleotide polymorphisms (SNPs) from COL11A2 by Agena Massarray. We evaluated these SNPs association with LDD using the chi‐square test and genetic model analysis.ResultsThe strongest associations with LDD were observed for polymorphisms in rs2071025. Carriers of “A” allele had an increased risk of LDD (OR = 1.47, 95% CI = 1.20–1.80, p = 0.0002) as compared with the “G” allele in allele model. We found that rs2071025 were associated with LDD in female and male from the stratification analyses (p < 0.05). Genetic models showed that rs986522(C) significantly increased the risk of LDD in female; however, in males, we did not find significant associations between the rs986522 and LDD risk.ConclusionThis study showed a genetic association with COL11A2 polymorphism in individuals with LDD. These data may provide novel insights into the pathogenesis of LDD, although further studies with larger numbers of participants worldwide are needed for validation of our conclusions.
A miniaturized 28 GHz 4‐bit phase shifter in 65 nm LP CMOS for multi‐channel 5‐G radios
Authors: Lee Junghwan , Seo Munkyo 
Published: December 2018

AbsractA 65 nm LP CMOS 4‐bit phase shifter for 28 GHz 5G applications is presented. Sharing inductor footprints and using a switched inductor allow ~50% of layout size reduction, compared to conventional design. On‐wafer testing shows that the fabricated phase shifter exhibits 14.3 dB average insertion loss over the 27.5–28.35 GHz band. Measured input and output return losses are >7.2 dB. Measured RMS phase and gain error are 9.4° and 2.7 dB at 28 GHz, respectively. Measured input P1dB is >11 dBm. The chip area excluding pads is 0.067 mm2,
×2 more compact than previous Ka‐band phase shifters, to the best of authors' knowledge. The presented phase shifter allows low‐cost IC implementation of multi‐channel 5G transceivers.
Reconfigurable rectenna array design with mutual coupling analysis
Authors: Lu Ping , Yang Xue‐Song , Wang Bing‐Zhong 
Published: December 2018

AbstractThis article introduces design of two frequency reconfigurable rectenna arrays, which are in direct current (DC) combining and in radio frequency (RF) combining configurations, respectively, with the mutual coupling analysis. We compare the performances in the conversion efficiency of the two arrays. For the mutual coupling analysis, the coupling coefficient matrix and the active DC patterns of the two rectenna arrays are calculated. By analyzing the mutual coupling, we find that the rectenna array in RF combining can achieve higher and more stable output DC power than that in DC combining. When the receiving antenna element spaces about 0.46λ0 and the rectifying circuit element spaces 0.17λ0, the proposed two‐element reconfigurable rectenna array in RF combining configuration achieves measured conversion efficiencies of 69.1% and 64.2% at two operation frequency modes, while simulated efficiency in DC configuration achieves 70.3% and 53.2% when the rectenna element spaces 0.38λ0.
Cucumis metuliferus reduces Meloidogyne incognita virulence against the Mi1.2 resistance gene in a tomato–melon rotation sequence
Authors: Expósito Alejandro , García Sergi , Giné Ariadna , Escudero Nuria , Sorribas Francisco Javier 
Published: December 2018

AbstractBACKGROUNDSusceptible tomato cv. Durinta, ungrafted or grafted onto cv. Aligator resistant rootstock, both followed by the susceptible melon cv. Paloma, ungrafted or grafted onto Cucumis metuliferus BGV11135, and in the reverse order, were cultivated from 2015 to 2017 in the same plots in a plastic greenhouse, infested or not with Meloidogyne incognita. For each crop, soil nematode densities, galling index, number of eggs per plant and crop yield were determined. Virulence selection was evaluated in pot experiments.RESULTSIn the tomato–melon rotation, nematode densities increased progressively for the grafted tomato, being higher than for ungrafted plants at the end of the study; this was not the case in the melon–tomato rotation. Grafted crops yielded more than ungrafted crops in the infested plots. Virulence against the Mi1.2 gene was detected, but not against C. metuliferus. Reproduction of M. incognita on the resistant tomato was ∼ 120% that on the susceptible cultivar after the first grafted tomato crop, but this decreased to just 25% at the end of the experiment.CONCLUSIONAlternating different resistant plant species suppresses nematode population growth rate and yield losses. Although this strategy does not prevent virulence selection, the level was reduced. © 2018 Society of Chemical Industry
Collaborating to manage performance trade‐offs: How fire departments preserve life and save property
Authors: Horwitz Jay R. , McGahan Anita M. 
Published: December 2018

Research SummaryWe examine how formal collaboration allows organizations to resolve performance trade‐offs that cannot be resolved informally. The theory is tested on U.S. fire departments, which pursue goals that sometimes conflict: reducing casualties and saving property. By relying on intrinsic motivation, informal collaboration reduces casualties and saves some property above what departments can achieve alone. Formal contracts are needed to achieve additional performance improvements on the goal of saving property. Contracts improve performance above what is accomplished informally by compelling collaboration even under casualty risk. Prior studies of collaboration that do not account for ex ante informality or performance trade‐offs may misstate the impact of collaboration on organization performance.Management SummaryLike many organizations, U.S. fire departments pursue multiple goals that sometimes conflict. For fire departments, these goals are reducing casualties and saving property. Goal conflict arises when firefighter lives are put at risk to save property. To improve performance on both goals, fire departments often collaborate with neighboring departments in nearby jurisdictions. In this paper, we examine how performance on both goals improves when departments collaborate informally through handshake agreements. However, performance in saving property—the goal that is less intrinsically motivating for firefighters—improves even more when the collaborating departments implement a formal contract. At the same time, casualties increase slightly. This is because a contract creates an obligation for an assisting department to save property even under a risk to firefighters' lives. The analysis shows how formal contracts are implemented to resolve trade‐offs that cannot be resolved informally. We conclude that the performance improvements associated with collaboration may be quite different than the improvements that follow the implementation of formal contracts. This is because contracts may deal only with marginal trade‐offs between the goals of the collaborators.
8:2 Fluorotelomer alcohol causes immunotoxicity and liver injury in adult male C57BL/6 mice
Authors: Wang Xia , Kong Baida , He Bingnan , Wei Lai , Zhu Jianbo , Jin Yuanxiang , Shan Yudong , Wang Weitao , Pan Chunqiang , Fu Zhengwei 
Published: December 2018

Abstract8:2 Fluorotelomer alcohol (8:2 FTOH) is widely used in houseware and industrial goods and is ubiquitous in the surrounding environment. 8:2 FTOH has been linked to hepatoxicity, nephrotoxicity, and reproductive toxicity, as well as endocrine‐disrupting effects. However, as of yet, the research regarding immunotoxicity of 8:2 FTOH remains largely limited. In the present study, adult male C57BL/6 mice were administered with 10, 30, and 100 mg/kg/d 8:2 FTOH by gavage for 28 days to investigate its immunotoxicity in vivo. The results showed that exposure to 8:2 FTOH caused increases in liver weight and histological changes in the liver, including vacuolation, cell swelling, immune cell infiltration, karyopyknosis and nuclear swelling. No histological change in either the spleen or the thymus was observed after administration of 8:2 FTOH. In addition, exposure to 8:2 FTOH reduced the concentration of IL‐1β in serum, and mRNA levels of IL‐1β, IL‐6, and TNF‐α in both the thymus and spleen. CXCL‐1 mRNA expression was downregulated in both the liver and thymus after 8:2 FTOH administration, while only IL‐1β mRNA expression was upregulated in the liver. Moreover, the exposure of primary cultured splenocytes to 8:2 FTOH inhibited the ConA‐stimulated proliferation of splenocytes at concentrations of 30 and 100 μM, and the LPS‐stimulated proliferation of splenocytes at 100 μM. Furthermore, 8:2 FTOH inhibited the level of secreted IFN‐γ in ConA‐stimulated splenocytes. The results obtained in the study demonstrated that 8:2 FTOH posed potential immunotoxicity and liver injury in mice. Our findings will provide novel data for the health risk assessment of 8:2 FTOH.
Impact of hospital hospitality house programs on quality of life and mood of patients and caregivers after hematopoietic stem cell transplant
Authors: Torres Maria E. , Hashmi Shahrukh K. , Stevens Maria A. , Tan Angelina D. , Callahan Valerie , Sloan Jeff A. , Hogan William J. , Litzow Mark R. , Roy Vivek , Foran James M. , Colon-Otero Gerardo 
Published: December 2018

Objective/background:
The quality of life (QOL) of hematopoietic stem cell transplant (HSCT) patients and their caregivers decreases during the first 8 days after HSCT.

Methods:
This prospective pilot study collected preliminary data on the impact of posttransplant living arrangements (hospital hospitality house [HHH] vs. hotel, apartment, or house [“hotel”]) and other factors on the QOL of HSCT patients and their caregivers. The predefined primary end point was QOL of patients and their caregivers on Day 30 (QOL30) as measured by the linear analog self-assessment (LASA).

Results:
Forty-four HSCT patients participated (HHH 23, hotel 21; allogeneic 18, autologous 26). No significant differences in QOL30 (mean LASA score) were noted between patient groups (55.6 [HHH] vs. 72.2 [hotel], p = .06) or between caregiver groups (77.8 [HHH] vs. 88.9 [hotel], p = .20). Multivariate analysis for QOL30 showed that baseline QOL (p = .006) and age (p = .049) were significant predictors of QOL30 after adjustment for sex, post-HSCT living place, and transplant type. Older patients (≥60 years) had a significantly lower QOL30 than younger patients (mean score, 51.6 vs. 75.3; p = .02).

Conclusion:
Efforts to improve QOL30 of HSCT patients and caregivers in the confined environment of an HHH should focus on patients with low baseline QOL and older patients.