bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Collagenolytic Bacteria in Human Samples: Screening Methods and Clinical Implications for Resolving and Preventing Anastomotic Leaks and Wound Complications
Authors: Guyton Kristina L. , Levine Zoe C. , Lowry Ann C. , Lambert Laura , Gribovskaja-Rupp Irena , Hyman Neil , Zaborina Olga , Alverdy John 
Published: July 2019

BACKGROUND:
Bacteria that produce collagen-digesting enzymes (collagenolytic bacteria) have been shown to play a critical and previously unappreciated role in anastomotic leak pathogenesis by breaking down host tissue extracellular matrix proteins. Detection of these bacteria is labor intensive, and no screening method currently exists.

OBJECTIVES:
We evaluated a rapid screening method developed to detect the presence of these collagenolytic bacteria in clinical samples, such as drain fluid, anastomotic tissue, or feces.

DESIGN:
We compared a new method of detecting collagenolytic bacterial species with a previously used technique using samples from a murine experimental model and then demonstrated the utility of this screening method in samples from patients with anastomotic complications.

SETTINGS:
All of the laboratory work and previous murine experiments were performed in Dr Alverdy’s laboratory at the University of Chicago under institutional review board–approved protocols.

PATIENTS:
Samples from patients with challenging wound complications were provided by participating clinicians with verbal patient consent. Given the small number of patients, this was determined to be institutional review board exempt.

MAIN OUTCOME MEASURES:
Whether this analysis can influence patient management and outcomes will require additional study.

RESULTS:
This screening method detects numerous strains of bacteria with collagenolytic properties, including the collagenolytic species that have been implicated previously in anastomotic leak. Once collagenolytic strains are identified, they can be speciated and tested for antibiotic resistance using standard laboratory techniques.

LIMITATIONS:
This study is limited by the small number of patient samples tested.

CONCLUSIONS:
We demonstrated the potential applicability of this assay to evaluate rare and complex anastomotic complications that often require analysis beyond standard culture and sensitivity assays. Future applications of this method may allow the development of strategies to prevent anastomotic leak related to collagenolytic bacteria. See Video Abstract at http://links.lww.com/DCR/A962.
Emergency Surgery for Obstructive Colon Cancer in Elderly Patients: Results of a Multicentric Cohort of the French National Surgical Association
Authors: Manceau Gilles , Mege Diane , Bridoux Valérie , Lakkis Zaher , Venara Aurélien , Voron Thibault , Sielezneff Igor , Karoui Mehdi 
Published: July 2019

BACKGROUND:
Although elderly patients constitute most of the patients undergoing surgery for obstructed colon cancer, available data in the literature are very limited.

OBJECTIVE:
The purpose of this study was to assess the management and outcomes of elderly patients treated for obstructed colon cancer.

DESIGN:
This was a multicenter, retrospective cohort study.

SETTINGS:
Between 2000 and 2015, 2325 patients managed for an obstructed colon cancer in member centers of the French National Surgical Association were identified. Data were collected by each center on a voluntary basis after institutional approval. Bowel obstruction was defined clinically and confirmed by imaging.

PATIENTS:
Three age groups were defined, including patients <75 years, 75 to 84 years, and ≥85 years.

MAIN OUTCOME MEASURES:
Postoperative and oncologic results in elderly patients with an obstructed colon cancer were measured. Relative survival was calculated as the ratio of the overall survival with the survival that would have been expected based on the corresponding general population.

INTERVENTIONS:
A total of 302 patients (13%) underwent colonic stent insertion, and 1992 (87%) underwent surgery as emergency procedure.

RESULTS:
A total of 2294 patients were analyzed (<75 y, n = 1200 (52%); 75–84 y, n = 650 (28%); and ≥85 y, n = 444 (20%)). Elderly patients were more likely to be women (p < 0.0001), to have proximal colon cancer (p < 0.0001), and to have a higher incidence of comorbidities (p < 0.0001). The use of colonic stent or the type of surgery was identical regardless of age. In patients with resected colon cancer, elderly patients had less stage IV disease (p < 0.0001). The absence of tumor resection (p < 0.0001) and definitive stoma rate increased with age (p < 0.0001). Postoperative mortality and morbidity were significantly higher in elderly patients (p < 0.0001), but surgical morbidity was similar across age groups (p = 0.60). Postoperative morbidity was correlated to the 6-month mortality rate in elderly (p < 0.0001). Overall and disease-free survivals were significantly lower in more elderly patients (p < 0.0001) but relative survival was not (p = 0.09).

LIMITATIONS:
It is quite difficult to know how to interpret these data as a whole, given the inherent bias in the study population, lack of ability to stratify by performance status, and long study period duration.

CONCLUSIONS:
Elderly patients have high morbidity with lower survival in the highest age ranges of elderly subgroups. These data should be considered when deciding on an operative approach. See Video Abstract at http://links.lww.com/DCR/A964.
Functional and Aesthetic Reconstruction for Microtia Using the Combination of Superficial Circumflex Iliac Artery Perforator Superthin Flap Transfer and Skin Grafting
Authors: Karakawa Ryo , Iida Takuya , Yoshimatsu Hidehiko , Kanayama Koji , Yamasoba Tatsuya 
Published: July 2019

Summary:
Microtia with congenital aural atresia is challenging to achieve aesthetically and functionally good results. We herein present a case where a vascularized superthin superficial circumflex iliac artery perforator (SCIP) flap was used for reconstruction of the external auditory canal (EAC) and a full-thickness skin graft was used for reconstruction of the postauricular region for a 10-year-old male who suffered from microtia with congenital aural atresia. After costal cartilage grafting (the first operation), EAC reconstruction and auricle elevation (the second surgery) was performed. After the atticoantrostomy, a superthin SCIP flap was rolled up in a sac and was inset to the newly created EAC. The postauricular skin defect was covered with full-thickness skin graft. The SCIP flap survived completely and good patency of the reconstructed EAC was accomplished, which results in an improvement of previous hearing loss. The skin graft survived completely, which eventually demonstrated aesthetically satisfactory results.
The Buccal Fat Pad: A Case Report and Retrospective Case Series
Authors: Weniger Frederick G. , Weidman Allan A. 
Published: July 2019

Summary:
Buccal fat contributes significantly to the contour of the face, but the contribution of buccal fat is often neglected on examination and in surgery. A case of isolated buccal fat removal is examined. Previous literature relevant to this case is discussed and the author’s experience from 10 subsequent lower facial rejuvenation surgeries combined with buccal fat reductions is presented with suggestions.
Streamlining Regulatory Activities Within Radiation Therapy Departments Using QATrack+
Authors: Angers Crystal , Bottema Ryan , Buckley Lesley , Studinski Ryan , Petzold Don , Abbassian Farhoud , Taylor Randy 
Published: July 2019

Abstract
Radiation therapy departments are faced with the challenge of tracking numerous quality control tests as well as monitoring service events affecting radiation therapy treatment units. Service events, in particular, pose a challenge since the clinic must be able to provide evidence to the regulatory body that both the service work and any required follow-up tests were recorded and authorized by the appropriate staff. This article presents an integrated approach to tracking quality control tests and service event logs using QATrack+. The newly developed version of this quality assurance software integrates quality control tracking with the service event log, allowing a direct link between a service event and any initiating routine tests or follow-up tests that are performed. This improves the ability of a licensee to ensure compliance with regulations and permits a simple platform from which to access all machine equipment tests and service events. Furthermore, this improves the ability of a department to assess the service record of equipment and to identify trends in failure modes.
BUCKLE-ASSOCIATED EPITHELIAL CYST MASQUERADING AS INTRAOCULAR INFLAMMATION
Authors: Crowell Eric , Stroh Inna , Wenick Adam , Burkholder Bryn 
Published: July 2019

Background/Purpose:
To describe a case of a rare, late scleral buckle-related complication, which was masquerading as ocular inflammation.

Methods:
Case report.

Results:
A 63-year-old woman with ocular history significant for cataract extraction with intraocular lens placement and retinal detachment repaired through pars plana vitrectomy and scleral buckle presents with anterior chamber inflammation and debris in the left eye. Uveitis workup was negative for any associated systemic disease. Anterior chamber washout and biopsy were nondiagnostic. At postoperative Month 1, she had recurrent anterior chamber debris and new debris noted in the vitreous cavity. A pars plana vitrectomy was performed, and during intraoperative scleral depression, copious strands of whitish material were expressed into the vitreous cavity. The scleral buckle was removed with additional whitish material noted within the encapsulated area. Papanicolaou stain of the material demonstrated a mixture of epithelial cells, histiocytes, lymphocytes, plasma cells, and neutrophils consistent with an epithelial cyst.

Conclusion:
Epithelial inclusion cysts are a rare complication of scleral buckle placement. These cysts are lined by a nonkeratinized, stratified squamous epithelium with or without goblet cells and most commonly occur after ocular trauma, inflammation, or surgical procedures. To the best of our knowledge, this is the first reported case of erosion of an epithelial inclusion cyst into the vitreous cavity.
ACUTE MACULAR EDEMA WITH SEROUS RETINAL DETACHMENT AFTER CATARACT SURGERY IN A VITRECTOMIZED EYE: A CASE REPORT
Authors: Bryan Eric A. , Cruz-Iñigo Yousef J. , Brems Robert N. , Bryan J. Shepard 
Published: July 2019

Purpose:
To present the first case of acute macular edema with serous retinal detachment after cataract surgery in a vitrectomized eye.

Methods:
A 63-year-old female patient, with history of pars plana vitrectomy and epiretinal membrane removal, underwent uneventful phacoemulsification surgery with injection of standard intracameral dose of cefuroxime (1 mg/0.1 mL of solution) at the end of the procedure.

Results:
First day after cataract surgery, visual acuity did not correlate with anterior segment findings, and funduscopic eye examination revealed acute macular edema with serous retinal detachment, which was confirmed by spectral domain optical coherence tomography. Fluorescein angiography showed no retinal or choroidal hyperpermeability. At 2-week follow-up visit, visual acuity had significantly improved, and there was complete resolution of macular edema and subretinal fluid.

Conclusion:
The current case suggests that acute macular edema with serous retinal detachment after cataract surgery with standard cefuroxime prophylaxis can occur even in vitrectomized eyes. A high level of suspicious is needed when visual acuity does not correlate with anterior segment findings immediately after cataract surgery. Similar to reports from nonvitrectomized eyes, visual prognosis was favorable.
Effect of Life Review on Quality of Life in Terminal Patients: A Systematic Review and Meta-Analysis
Authors: HUANG Mei-Hua , WANG Ruey-Hsia , WANG Hsiu-Hung 
Published: July 2019

ABSTRACT

Background
Enhancing quality of life takes precedence in the terminal stage of a disease, when a cure is considered impossible and all alternative methods to prevent disease progression have been exhausted. Life review, involving appreciating accomplishments and resolving conflicts, is widely considered to be an effective approach to bringing peace to terminal patients.

Purpose
This study was conducted to assess the effects of life review on quality of life in terminal patients.

Methods
The Cochrane Library, PubMed, MEDLINE, CINAHL, CEPS, and ProQuest databases were searched for original studies published between 2007 and July 2018. Studies that used experimental designs to assess the effects of life review on quality of life in terminal patients, involved patients aged >18 years, and were published in English or Chinese were considered eligible for inclusion. Studies that measured quality of life in individuals other than patients as well as unpublished papers or data were excluded. The search terms used included “life review,” “end of life,” “terminal or terminally ill,” “advanced cancer,” “palliative,” “hospice,” and “quality of life.” The quality of each included study was assessed using the Downs and Black checklist.

Results
Six studies with 296 patients were included in the review. The participants in the included studies were from multiple countries. Life review was found to affect quality of life significantly (95% CI [0.147, 0.668], Z = 3.062, p < .05). The selected studies exhibited moderate heterogeneity (I
2 = 42.407, p > .1).

Conclusions
Life review was found to affect quality of life significantly in the participants in the included studies. The feasibility and safety of applying life review interventions should be considered for terminal patients, and implementers of these interventions should be trained and qualified. Only a few studies in the literature have evaluated the effects of life review therapy in terminal patients. Further studies that use stricter selection criteria are necessary to evaluate the efficacy of the life review intervention before its adoption in clinical practice.
Uptake of 18F-Fluciclovine in Paget Disease
Authors: Akin-Akintayo Oladunni O. , Bonta Dacian , Barron Bruce 
Published: July 2019

Abstract
Since its recent approval by the United States Food and Drug Administration, fluciclovine PET-CT has gained widespread use for imaging of recurrent prostate cancer patients. As an amino acid–based radiotracer transported by LAT-1 and ASCT-2 transporters, fluciclovine exploits the up-regulation of amino acid transporters in malignant cells. We present a rare case of fluciclovine uptake in Paget disease in a 58-year-old man with suspected recurrent prostate cancer and asymmetric increased left hemipelvic uptake on imaging.
A Hungry Bone Syndrome Predicted by 18F-Fluorocholine PET/CT
Authors: Paepegaey Anne-Cécile , Velayoudom Fritz-Line , Housni Selma , Gauthé Mathieu , Groussin Lionel 
Published: July 2019

Abstract
Predicting hungry bone syndrome (HBS) after surgical cure of primary hyperparathyroidism (PHPT) can be challenging. A 57-year-old man diagnosed with PHPT was assessed preoperatively by 18F-fluorocholine PET/CT. An intense and diffuse tracer uptake of the axial and peripheral skeleton was visualized, in addition to a pathologic uptake suggestive of hyperfunctioning parathyroid gland. After the removal of a parathyroid adenoma, a severe and prolonged HBS requiring high doses of calcium and active metabolites of vitamin D was observed. This observation suggests that intense and diffuse bone uptake on 18F-fluorocholine PET/CT could be a predictive factor for HBS in patients with PHPT.
Giant Melanotic Malignant Peripheral Nerve Sheath Tumor in the Pelvis
Authors: Liu Entao , Sun Taotao , Liu Chao , Wang Siyun , Wang Shuxia 
Published: July 2019

Abstract
Melanotic malignant peripheral nerve sheath tumor is an extremely rare tumor, which originates from the neural crest, and more than half the cases are associated with Carney complex (myxomas, spotty pigmentation, and endocrine abnormalities). Herein, we have presented a case of a melanotic malignant peripheral nerve sheath tumor, which is not associated with Carney complex. The patient underwent preoperative nonenhanced CT, contrast-enhanced CT, and 18F-FDG PET/CT scans, which showed a large pelvic tumor with heterogeneous enhancement and increased 18F-FDG uptake. Subsequently, the patient underwent complete resection of the tumor.
Hamartoma of Mature Cardiac Myocytes Mimicking Malignancy on 18F-FDG PET/CT Images
Authors: Jiang Yang , Ma Xiaowei , Tan Yanlin , Lu Qingqing , Wang Yunhua 
Published: July 2019

Abstract
Hamartoma of mature cardiac myocytes is an extremely rare type of benign cardiac tumor with a slow growth rate and generally occurs in adults. We report a case with hamartoma of mature cardiac myocytes of the right auricle demonstrating intense 18F-FDG uptake and a large amount of pericardial effusion on PET/CT mimicking malignancy in a 41-year-old man. Hamartoma of mature cardiac myocytes should be considered among the differential diagnoses when an 18F-FDG-avid primary focal cardiac mass is found in patients with malignant features on PET/CT imaging.
Evaluation of Lung Cancer and Neuroendocrine Neoplasm in a Single Scan by Targeting Both Somatostatin Receptor and Integrin αvβ3
Authors: Zheng Yumin , Wang Hanping , Tan Huangying , Cui Xiaoxia , Yao Shaobo , Zang Jie , Zhang Li , Zhu Zhaohui 
Published: July 2019

Abstract

Purpose
This pilot study aimed to prove the complementary value of a novel 68Gallium-labeled heterodimeric peptide, 68Ga-NOTA-3P-TATE-RGD, in detection and evaluation of tumors with somatostatin receptor subtype 2 or integrin αvβ3 overexpression, including non-small cell lung cancer (NSCLC), small-cell lung cancer (SCLC), neuroendocrine tumor (NET), and neuroendocrine carcinoma (NEC).

Methods
With institute review board approval and written informed consent, 32 patients with pathologically diagnosed lung cancer (18 NSCLC, 14 SCLC) and 12 patients with neuroendocrine neoplasm (8 NET, 4 NEC) patients were recruited to undergo 68Ga-NOTA-3P-TATE-RGD PET/CT. For comparison, the NSCLC patients also underwent 68Ga-NOTA-TATE PET/CT, the SCLC patients underwent 68Ga-NOTA-RGD PET/CT, and the neuroendocrine neoplasm patients underwent 18F-FDG PET/CT within 3 days. The maximum standardized uptake value (SUV) of the primary tumor (T) and mean SUV of the blood pool (B) were measured, and the T/B ratios were calculated for comparison.

Results
In the primary tumors of NSCLC, the T/B ratios of 68Ga-NOTA-3P-TATE-RGD were significantly higher than those of 68Ga-NOTA-TATE (4.54 ± 3.00 versus 4.10 ± 2.83, P = 0.0058). In SCLC, the T/B ratios of 68Ga-NOTA-3P-TATE-RGD were significantly higher than those of 68Ga-NOTA-RGD (6.06 ± 6.09 versus 2.65 ± 1.19, P = 0.0344). In NET, the T/B ratios of 68Ga-NOTA-3P-TATE-RGD were 36.13 ± 33.84, significantly higher than those of 18F-FDG (2.91 ± 1.71, P = 0.0234). In NEC, there were no significant difference between the T/B ratios of 68Ga-NOTA-3P-TATE-RGD (4.80 ± 0.85) and those of 18F-FDG (3.56 ± 0.74, P = 0.1833).

Conclusions
This proof-of-concept study preliminarily demonstrates the efficacy of the dual targeting 68Ga-NOTA-3P-TATE-RGD PET/CT in the evaluation of lung cancer and neuroendocrine neoplasm in a single scan.
18F-DCFPyL PET/CT in a Single Large Metastasis With Prostate-Specific Antigen Level of 856 ng/mL
Authors: Wondergem Maurits , Srbljin Sandra , van der Zant Friso M. , Broos Wouter A. M. , Knol Remco J. J. 
Published: July 2019

Abstract
Literature shows that prostate-specific membrane antigen (PSMA) PET/CT may detect biochemical recurrence of prostate cancer at low prostate-specific antigen (PSA) levels, including detection of oligometastatic disease and hence direct metastasis-directed therapy. Although it is generally accepted that higher PSA values indicate higher disease burden, few data are available on the relation between PSA levels and number of detected metastases on PSMA PET/CT. This report demonstrates a patient with high PSA levels (856 ng/mL) at time of biochemical recurrence that showed only 1 metastasis on PSMA PET/CT. Combined androgen deprivation therapy and radiation therapy resulted in a complete biochemical response.
Isolated Small Bowel Metastasis From Gastric Cancer Detected by 18F-FDG PET/CT
Authors: Fan Qiuping , Su Minggang 
Published: July 2019

Abstract
Small bowel metastasis is rare. Most patients are diagnosed after presenting serious complications. The primary tumors generally arise from breast, lung, and melanoma, but rarely from the stomach. Here we present a case of a gastric cancer patient with asymptomatic small bowel metastasis diagnosed at staging using 18F-FDG PET/CT. The bowel lesion could not be found on the full-dose CT component of PET/CT. Previous staging contrast CT also made a missed diagnosis. This case reminds us that PET/CT can be used to detect unsuspected metastasis. It may be suitable for routine initial staging, especially on a patient with poor prognosis.
18F-Choline PET/CT Detected Skull Base Paraganglioma
Authors: Harbourne Alexander D. , Bradley Kevin M. 
Published: July 2019

Abstract
We present a case of a right skull base paraganglioma detected using 18F-choline PET/CT in a 63-year-old man. The 18F-choline PET/CT scan was performed to assess a known prostate cancer. In addition, the scan demonstrated a mildly choline-avid (SUVmax, 3.8) tumor within the carotid sheath of the right skull base, extending through the jugular foramen to the cerebellomedullary and cerebellopontine angles. 18F-choline may provide a superior alternative to FDG in imaging paragangliomas of the skull base because, unlike FDG, there is no significant 18F-choline uptake in the adjacent brain.
Incidental Detection of Adrenal Pheochromocytoma on 99mTc-DTPA Renal Dynamic Scintigraphy
Authors: Mi Yanxia , Huang Jianmin , Ren Yuan , Xie Peng 
Published: July 2019

Abstract
A 53-year-old man with a history of primary hypertension for over 8 years underwent 99mTc-DTPA renal dynamic scintigraphy to evaluate the renal function. The images revealed an unexpected focus of abnormally increased DTPA activity in the region superior to the upper pole of the right kidney. Subsequent MRIs confirmed an adrenal mass. The results of pathological examination and immunohistochemistry after the resection of the lesion were consistent with adrenal pheochromocytoma.
Comparison of Diagnostic Performance of B-Mode Ultrasonography and Shear Wave Elastography in Cervical Lymph Nodes
Authors: Kang Hye Jin , Seo Mirinae , Sohn Yu-Mee , Yun Seong Jong , Min Sun Young , You Myung-Won , Yeon Eung Koo 
Published: July 2019

Abstract
The purpose of this study was to compare the diagnostic performance of B-mode ultrasonography (US) and shear wave elastography (SWE) for differentiating benign from malignant cervical lymph nodes (LNs). This study evaluated 130 cervical LNs in 127 patients. On conventional B-mode US, short-axis and long-axis diameters, long-to-short-axis ratio, cortical morphology, border, and presence of necrosis or calcification were evaluated. Maximum elasticity value (Emax) was collected for SWE. The area under the receiver operator characteristic curve (AUC), sensitivity, and specificity of B-mode US features and SWE were compared. Final histopathologic results showed 89 benign and 41 metastatic LNs. Among the B-mode US features, cortical morphology had the highest AUC (0.884). When 54 kPa of Emax was applied as a cutoff value, the SWE showed significantly lower AUC than cortical morphology (0.734, P = 0.02). Both sensitivity and specificity for cortical morphology on B-mode US were higher than for Emax (80.5% vs 65.9%, P = 0.212 and 89.9% vs 76.4%, P = 0.026, respectively). Conventional B-mode US resulted in higher diagnostic yield than SWE in evaluating cervical LNs in our study. However, further studies on potential factors that may affect the SWE velocity are needed to validate the diagnostic value of SWE.