bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Ferrule Location with Varying Heights on Fracture Resistance and Failure Mode of Restored Endodontically Treated Maxillary Incisors
Authors: Santos Pantaleón Domingo , Valenzuela Fabio M. , Morrow Brian R. , Pameijer Cornelis H. , García‐Godoy Franklin 
Published: May 2019

AbstractPurposeTo investigate the effect of the location of a partial ferrule on 2 walls and the influence of ferrule height variations on remaining walls, fracture resistance, and failure mode of maxillary incisors endodontically treated and restored with fiber posts.Materials and MethodsSixty intact human maxillary central incisors were divided into 6 groups (n = 10): no ferrule (NF), 2‐mm ferrule (CF2), absence of lingual wall and 1 proximal wall with remaining walls’ height, 1 mm (IF1), 2 mm (IF2), 3 mm (IF3), and 4 mm (IF4). They were restored with a fiberglass post and composite resin core. Complete metal crowns were then cemented on all specimens. Completed specimens were subjected to thermal cycling (6000 cycles, 5°C/55°C) followed by the immediate testing of fracture resistance. After failure, the specimens were sectioned buccolingually and evaluated to identify the mode of failure. The data were analyzed with an ANOVA and the Student‐Newman‐Keuls multiple comparison tests (α = 0.05).ResultsAn incomplete ferrule (IF2) with the lingual wall missing and 1 proximal wall had a fracture resistance of 494 ± 137 N, which was significantly less that of a complete ferrule (CF2) (707 ± 162 N, p = 0.002). An increase of 3 to 4 mm in height of the remaining walls had negligible influence on the fracture resistance: 514 ± 117 N (IF3), 557 ± 177 N (IF4). Partial decementation was observed in all specimens of IF3 and IF4, in 9 of IF1 and IF2, in 6 in NF, and in 3 in CF2. Root fractures occurred in 7 specimens, 4 in CF2, 1 in IF1, 1 in IF2, and 1 in IF4. Cracks under the cemento‐enamel junction occurred in 4 specimens (NF and IF1), in 5 (IF2 and IF3), and in 6 (CF2 and IF4) and were considered catastrophic failures.ConclusionsSpecimens with a complete ferrule of 2 mm height were more resistant to fracture than specimens with 2 mm height and absence of the lingual wall and 1 proximal wall. A 3 or 4 mm wall height increase was associated with an insignificant increase in fracture resistance and cannot compensate for the absence of the lingual wall and 1 proximal wall.
Ethical Resonance
Authors: Prasad Leela 
Published: May 2019

AbstractThis essay defines ethical resonance through an ethnographic interlude that paves the way for a broader theorization of the concept. It begins by contextually recounting the story of an individual who had stayed at Sevagram, Mahatma Gandhi’s last ashram in 1944, shadowing Gandhi for some 20 days. The young man’s brief meeting with Gandhi in which Gandhi uttered only one sentence transformed him for his lifetime. I reflect on the experience and its narrative qualities to explore the broader question of why one is moved, and moved enough to be altered. I propose that the theorization of resonance in modern physics, in phenomenology, and in 11th‐century Sanskrit poetics is productive for understanding the subjective and the trans‐subjective elements that underlie ethical persuasion. I argue that the idea of resonance helps bridge the affective and the aesthetic in moral self‐formation that occurs in everyday life.
Evaluation of pigeon pea leaves (Cajanus cajan) replacing alfalfa meal on growth performance, carcass trait, nutrient digestibility, antioxidant capacity and biochemical parameters of rabbits
Authors: Chen Yiye , Zhu Ni , Chen Xiaoyang , Liu Guangbin , Li Yaokun , Guo Yongqing , Deng Ming , Liu Dewu , Sun Baoli 
Published: May 2019

AbstractA 30‐day experiment was performed to determine the effect of pigeon pea leaves (PPL) on growth performance, carcass trait, meat quality, nutrient digestibility, antioxidant capacity and biochemical parameters of growing rabbits. In a completely randomized design, PPL replaced alfalfa meal at the level of 0%, 10%, 20% and 30%, which were named PPL0 (control), PPL10, PPL20 and PML30 respectively. Two hundred New Zealand white rabbits at 6 weeks with similar weight (870.23 ± 15.98 g) were allocated to four dietary groups with five replicates containing 10 rabbits/per replicate (male). The results showed that: (a) PPL powder contained 24.26% crude protein, 4.34% crude fat, 17.86% crude fibre, 7.05% ash, 1.35% calcium, 0.28% phosphorus, 1.09% lysine and 0.20% methionine, and the chemical compositions are on DM basis; (b) the ratio of feed to gain of rabbits fed diet PPL10 was significantly better (p < 0.05) than those fed other three diets; (c) the content of longissimus dorsi (LD) moisture in the rabbits fed diets without PPL (control group) was 12% lower than that in the PPL30 diets (60.1 vs. 72.1; p < 0.05). In PPL10, PPL20 and PPL30 diets, the leg muscle (LM) b*(yellowness) value was 33%, 30% and 22.6% higher than the control group respectively. The rabbits fed diets PPL0 had lower (p < 0.05) LM crude protein and ash and higher (p < 0.05) crude fat of LD and LM as compared with those fed other diets; (d) crude protein and energy digestibility of PPL0 and PPL10 diets were significantly higher (p < 0.05) than PPL30 diets; and (e) serum glutathione peroxidase (GSH‐Px) activity of the rabbits fed PPL10 and PPL30 diets was significantly higher (p < 0.05) than that fed PPL20 diets. Liver total antioxidant capacity (T‐AOC) activity of the PPL30 groups was 1.3% higher (p < 0.05) than the PPL10 group. Additionally, the control group (PPL0) had the highest (p < 0.05) blood urea nitrogen (BUN), total cholesterol (TCHO) and low‐density lipoprotein cholesterol (LDLC) content compared with the groups supplemented with PPL. The PPL30 group had the highest (p < 0.05) triiodothyronine (T3) and tetraiodothyroxine (T4) value among the dietary groups.
In ovo injection of flavanone on bone quality characteristics, biochemical parameters and antioxidant enzyme status of blood in daily chicks
Authors: Ranjbar Zahra , Torki Mehran , Karimi Torshizi Amir Ali 
Published: May 2019

AbstractIn ovo injection (IOI) of Naringin (N), flavanone was examined on post‐hatch blood biochemical parameters, antioxidant status and bone characteristics. Fertile eggs (n = 700) were distributed in seven groups with 100 eggs. On 14th and 17.5th days of incubation, four groups were injected using 15 or 30 mg active ingredient levels of naringin/0.5 ml saline/egg, low and high level, into amnion sac. Controls include sham (injected normal saline, 0.5 ml/egg on day 14 and 17.5th) and un‐injected group. IOI of high naringin and saline on 14th day of incubation resulted in lower hatchability and then higher mortality in last week of embryonic life. On day hatch, high levels of injected groups more body weight compared to the control. Chick length was increased at high levels of naringin on day 17.5th compared to control and saline injected. Quality traits of bones were improved in naringin‐injected groups compared to control. IOI of naringin influenced thyroid hormones on 14th day of incubation. Naringin groups influenced the Alkaline phosphatase (ALP), Calcium (Ca), superoxide dismutase (SOD), blood biochemical and lipids. Totally, amniotic IOI of naringin in last days of developing embryo may be useful for hatched chick, development of leg long bone or effect on biochemical metabolites by levels of flavanone that it needs more research.
Mesoscale and microscale shock effects in the LL6 S4 chondrites Saint‐Séverin and Elbert: A tale of two breccias
Authors: Hugo Richard C. , Ruzicka Alex M. , Rubin Alan E. 
Published: May 2019

AbstractSaint‐Séverin and Elbert, two LL6 chondrite breccias, were systematically studied to evaluate multiple deformation effects on spatial scales ranging from thin section (mesoscale) to micron‐submicron (microscale) using optical microscopy, electron backscatter diffraction (EBSD), and transmission electron microscopy (TEM). The different techniques provide consistent results but have complementary strengths, together providing a powerful approach to unravel even complex impact histories. Both meteorites have an S4 conventional shock stage, but interclast areas are more deformed, and clasts are more deformed in Elbert than in Saint‐Séverin. TEM and EBSD data provide compelling evidence that Saint‐Séverin experienced significant shock deformation while already hot, and cooled rapidly afterward, as a result of a major, possibly disruptive impact on the LL chondrite parent body ~4.4 Ga ago. In contrast, Elbert was shocked from a cold initial state but was heated significantly during shock, and cooled in a localized hot impact deposit on the LL asteroid. Both meteorites probably were shocked at least twice; data for Saint‐Séverin are best reconciled with a three‐impact model.
Improving the lives of millions through new double fortification of salt technology
Authors: Diosady Levente L. , Mannar M.G. Venkatesh , Krishnaswamy Kiruba 
Published: May 2019

AbstractMicronutrient deficiencies (including iodine and iron deficiency) is a global health problem affecting one third of the world's population. Salt is an ideal carrier for food fortification as it is universally consumed at equal rates, independently of economic status, and it is industrially processed. Addressing iron and iodine deficiencies together is a challenge, due to interaction between iodine and iron, negating the effect of added iodine. This paper explains the development of an improved microencapsulation‐based technology to produce iron premix, which, when added to iodized salt, is stable and organoleptically indistinguishable. Ferrous fumarate was extruded, followed by cutting, sieving to achieve a size of 300–710 μm (salt grain size). Agglomerated extrudates were microencapsulated (5% hydroxypropyl methylcellulose and 5% soy stearin) to form iron premix. Microencapsulation ensures that the added micronutrients are stable without interaction or degradation. Double Fortified Salt is formed by blending iron premix with iodized salt (1:200 ratio). This technology was transferred to India for industrial scale‐up. The public distribution system was utilized to establish and monitor an efficient distribution network for DFS in a transparent manner. The scale‐up process was initially demonstrated in the state of Uttar Pradesh, following its success two more Indian states have started distribution of DFS. At present, the DFS with iron and iodine is reaching 60 million people in India. This important health intervention technology through food fortification has the potential to be scaled globally to ensure a world free from iron deficiency anemia.
Intraspecific divergence in floral‐tube length promotes asymmetric pollen movement and reproductive isolation
Authors: Minnaar Corneile , de Jager Marinus L. , Anderson Bruce 
Published: May 2019

SummaryThe causative link between phenotypic divergence and reproductive isolation is an important but poorly understood part of ecological speciation. We studied the effects of floral‐tube length variation on pollen placement/receipt positions and reproductive isolation.In a population ofLapeirousia anceps(Iridaceae) with bimodal floral‐tube lengths, we labelled pollen of short‐ and long‐tubed flowers with different colour fluorescent nanoparticles (quantum dots). This enabled us to map pollen placement by long‐ and short‐tubed flowers on the only floral visitor, a long‐proboscid fly. Furthermore, it allowed us to quantify pollen movement within and between short‐ and long‐tubed flowers.Short‐ and long‐tubed flowers placed pollen on different parts of the pollinator, and long‐tubed flowers placed more pollen per visit than short‐tubed flowers. This resulted in assortative pollen receipt (most pollen received comes from the same phenotype) and strong but asymmetric reproductive isolation, where short‐tubed plants are more reproductively isolated than long‐tubed plants.These results suggest that floral‐tube length divergence can promote mechanical isolation in plants through divergence in pollen placement sites on pollinators. Consequently, in concert with other reproductive isolation mechanisms, selection for differences in floral‐tube length can play an important role in ecological speciation of plants.
A national study of nursing homes as learning environments according to undergraduate nursing student’s perspective
Authors: Gonella Silvia , Brugnolli Anna , Terzoni Stefano , Destrebecq Anne , Saiani Luisa , Zannini Lucia , Dimonte Valerio , Canzan Federica , Mansutti Irene , Palese Alvisa ,   the SVIAT TEAM
Published: May 2019

AbstractBackgroundNursing students report care of the older people as an undesirable career pathway. Positive clinical placement experiences influence students’ attitudes and career intentions with respect to nursing home (NH) setting. The clinical environment's quality depends on meaningful learning opportunities, the relationship with the preceptors, and the pedagogical atmosphere as influenced by the staff–student interactions.AimThe aim of this study was to explore nursing students’ perceptions on their clinical learning experience and competence learned in the NH setting as compared to other clinical areas.MethodsA secondary analysis was performed of an Italian national cross‐sectional study involving 9,607 nursing students attending 95 different three‐year bachelor laureate nursing programmes in 27 universities. A questionnaire exploring individual and nursing programme variables was devised. Moreover, students self‐reported the perceived quality of the clinical learning experience using the Clinical Learning Quality Evaluation Index tool and the degree of competence learned using a four‐point Likert‐type scale.ResultsStudents in the NH setting scored the overall quality of the learning environment significantly higher (p = 0.046) compared to those experiencing other clinical settings, and they scored higher learning occasions (p = 0.002) and self‐directed learning opportunities (p = 0.018). No difference emerged in the perceived mean degree of competences learned at the end of the clinical rotation (p = 0.271).ConclusionNursing students perceive the NH setting to be a good quality learning environment with valuable learning opportunities and self‐directed learning opportunities compared to other settings. The nursing home setting provides opportunities to acquire clinical competences comparable to the ones in other clinical settings such as hospital units.Implications for practiceNursing home settings should be considered by all nursing programmes as a learning environment particularly worthy for students at different levels of their education.
Natural rubber biosynthesis in plants, the rubber transferase complex, and metabolic engineering progress and prospects
Authors: Cherian Sam , Ryu Stephen Beungtae , Cornish Katrina 
Published: May 2019

SummaryNatural rubber (NR) is a nonfungible and valuable biopolymer, used to manufacture ~50 000 rubber products, including tires and medical gloves. Current production of NR is derived entirely from the para rubber tree (Hevea brasiliensis). The increasing demand for NR, coupled with limitations and vulnerability of H. brasiliensis production systems, has induced increasing interest among scientists and companies in potential alternative NR crops. Genetic/metabolic pathway engineering approaches, to generate NR‐enriched genotypes of alternative NR plants, are of great importance. However, although our knowledge of rubber biochemistry has significantly advanced, our current understanding of NR biosynthesis, the biosynthetic machinery and the molecular mechanisms involved remains incomplete. Two spatially separated metabolic pathways provide precursors for NR biosynthesis in plants and their genes and enzymes/complexes are quite well understood. In contrast, understanding of the proteins and genes involved in the final step(s)—the synthesis of the high molecular weight rubber polymer itself—is only now beginning to emerge. In this review, we provide a critical evaluation of recent research developments in NR biosynthesis, in vitro reconstitution, and the genetic and metabolic pathway engineering advances intended to improve NR content in plants, including H. brasiliensis, two other prospective alternative rubber crops, namely the rubber dandelion and guayule, and model species, such as lettuce. We describe a new model of the rubber transferase complex, which integrates these developments. In addition, we highlight the current challenges in NR biosynthesis research and future perspectives on metabolic pathway engineering of NR to speed alternative rubber crop commercial development.
Strawberry tonoplast transporter, FaVPT1, controls phosphate accumulation and fruit quality
Authors: Huang Yun , Xu Peng‐Hao , Hou Bing‐Zhu , Shen Yuan‐Yue 
Published: May 2019

AbstractPhosphorus (P) is essential for plant growth and development, and the vacuole is an important organelle for phosphate storage. However, the tonoplast phosphate transporter in fleshy fruits remains unknown. In this study, based on the strawberry (Fragaria × ananassa) fruit transcriptome data, a tonoplast‐localized vacuolar phosphate transporter with SPX and major facilitator superfamily domains, FaVPT1, was identified. FaVPT1 expression was highest in the fruits and could be induced by sucrose. Using transient transgenic systems in strawberry fruit, the downregulation and upregulation of FaVPT1 inhibited and promoted ripening, respectively, and affected phosphate contents, fruit firmness, sugar and anthocyanin contents, and ripening‐related gene transcription. FaVPT1 could rescue Pi absorption in both yeast and the Arabidopsis atvpt1 mutant, confirming the similar function of FaVPT1 and AtVPT1, a previously identified tonoplast phosphate transporter in Arabidopsis. The Escherichia coli–expressed SPX domain of FaVPT1 could strongly bind to InsP6 with a Kd of 3.5 μM. The results demonstrate that FaVPT1 is a tonoplast phosphate transporter and regulates strawberry fruit ripening and quality, to a large extent, via sucrose.
A Viewpoint on Research for Social Business Entrepreneurship
Authors: Desai Sameeksha , Tyler John E. 
Published: May 2019

AbstractThis Viewpoint essay outlines key considerations for research on entrepreneurship, and for social business entrepreneurship specifically, considering the wide range of forms and essentially heterogeneous nature of this broad set of businesses. Themes related to practical research and key questions are outlined, along with considerations for researchers as the social business entrepreneurship space continues to evolve.
Over the ROC methodology: Productivity, economic size and firms’ export thresholds
Authors: Costa Stefano , Sallusti Federico , Vicarelli Claudio , Zurlo Davide 
Published: May 2019

AbstractWe identify the minimum combinations of productivity and “economic size” that Italian manufacturing firms need to achieve in order to access international markets. These “export thresholds” are estimated by applying, for the first time in economics, the ROC (receiver operating characteristics) methodology. In this way, we detect a model‐based (rather than a subjectively determined) cut‐off that allows to identify exporters and nonexporters and provides a measure of each firm’s distance from the export threshold. This methodology also paves the way to investigate other determinants of thresholds, thus helping to design more effective policy interventions to reduce barriers to trade.
Narrowest-Over-Threshold Detection of Multiple Change Points and Change-Point-Like Features
Authors: Baranowski Rafal , Chen Yining , Fryzlewicz Piotr 
Published: May 2019

SummaryWe propose a new, generic and flexible methodology for non-parametric function estimation, in which we first estimate the number and locations of any features that may be present in the function and then estimate the function parametrically between each pair of neighbouring detected features. Examples of features handled by our methodology include change points in the piecewise constant signal model, kinks in the piecewise linear signal model and other similar irregularities, which we also refer to as generalized change points. Our methodology works with only minor modifications across a range of generalized change point scenarios, and we achieve such a high degree of generality by proposing and using a new multiple generalized change point detection device, termed narrowest-over-threshold (NOT) detection. The key ingredient of the NOT method is its focus on the smallest local sections of the data on which the existence of a feature is suspected. For selected scenarios, we show the consistency and near optimality of the NOT algorithm in detecting the number and locations of generalized change points. The NOT estimators are easy to implement and rapid to compute. Importantly, the NOT approach is easy to extend by the user to tailor to their own needs. Our methodology is implemented in the R package not.
On how the immune system preferentially interacts with antigen‐specific molecules bound to antigen over unbound molecules, with emphasis on B cell receptor signalling
Authors: Bretscher Peter A. , Al‐Yassin Ghassan A. 
Published: May 2019

AbstractAntigen‐specific molecules of the immune system, namely antibodies, the membrane immunoglobulins (mIgs) of B cells and T cell receptors (TcRs), can all signal their interaction with antigen. There are different mechanisms by which this signalling could occur. These mechanisms can be divided into two general categories: allosteric and non‐allosteric. In allosteric mechanisms, the monovalent binding of the antigen to the receptor triggers a conformational change at the binding site that is propagated to an invariant part of the receptor, a change recognized by a sensing unit. We argue allosteric mechanisms are implausible. Non‐allosteric mechanisms depend on steric effects due to the antigen's size and/or multivalency. We consider two non‐allosteric mechanisms by which the mIg of B cells has been envisaged to signal its interaction with antigen: the popular cross‐linking model and the dissociation activation model. We argue, on the basis of both experimental observations and physiological considerations, that the dissociation activation model, developed by Reth and his colleagues, is uniquely plausible.