bluuebunny/crossref_metadata_2025_split huggingface dataset:
The mechanism of HBx protein to promote the initiation and progression of hepatocellular carcinoma
Authors: Zhang Muyao , Wei Xing , Wang Zhenfei 
Published: May 2018

AbstractHepatocellular carcinoma (HCC) is the sixth most common malignancy worldwide and the third most common cause of death from cancer, after lung and stomach cancer. Hepatitis B virus (HBV) infection is closely related to HCC and is a major cause of HCC. HBV is a lysogenic virus of the hepadnavirus family. Its genome presents a slack, ring-like, double-chain structure, containing four open reading frames. The X region encodes the product HBV X protein (HBx), which is a multifunctional regulatory protein that plays an important role in intracellular signal transduction, viral genome replication and transcription, cell proliferation and apoptosis, cell cycle progression, protein degradation, and genetic stability of hepatocytes. This article summarizes the recent research on the mechanism of promotion of initiation and progression of HCC by HBx protein.
Contributions to Improve Online Learning Through Adaptive Hypermedia Techniques
Authors: Abraham-Curto Javier 
Published: May 2018

Abstract
The personalization of learning through the automatic adaptation of the educational process, especially for the contents, is regarded as an important and necessary step for the improvement of education in the future. It is believed that through individualization get improved efficiency, increased speed and quality of learning for students and by automating the process, improved efficiency, better resource utilization, scalability of the process learning. To achieve this goal we have developed different strategies. One of them are looking for Adaptive Hypermedia Systems adjust all contents in a atuomática to the characteristics of each user.
Data Portability Among Providers o Platform as a Service
Authors: Androcec Darko 
Published: May 2018

Abstract
Platform as a service model has certain obstacles, including data lock-in. It is expensive and time-consuming to move data to the alternative providers. This paper presents data storage options in platform as a service offers and identifies the most common data portability problems between various commercial providers of platform as a service. There are differences among their storage models, data types, remote APIs for data manipulation and query languages. Representing data models of platform as a service and data mappings by means of ontology can provide a common layer to achieve data portability among different cloud providers.
A Proposal of a Multi-Agent System for Adapting Learning Contents to User Competences, Context and Mobile Device
Authors: Garcia-Cabot Antonio 
Published: May 2018

Abstract
E-learning has been a revolution in recent years in the training field. This, combined with the increased use of the mobile devices has caused the emergence of the m-learning. Hence new problems have appeared in the training field, such as showing correctly some learning contents in a mobile device that has restricted features or taking into account the learner’s context in the learning process, because the learner can be anywhere. Because of this, this paper proposes a new multi-agent system for adapting the learning contents to the learner’s competences, to the learner’s context and to his/her mobile device. The paper also describes in detail the prototype developed for testing the proposed design.
Comparison Of Oxidation Resistance of TiAlN Monolayer Coating And Its NaCo3 Nanostructured Version
Authors: Sahul Martin , Zacková Paulína , Čaplovič Ľubomír , Šalgó Kristián , Bohovičová Jana , Sondor Jozef 
Published: May 2018

Abstract
The contribution deals with comparison of oxidation resistance of classical TiAlN monolayer coating and its advanced high hard nanostructured and multilayered nACo3 version at elevated temperatures. Both coatings were deposited onto AISI M36 high speed steel using unique LAteral Rotating Cathodes process (LARC®). “In - situ” X-Ray diffraction analysis was employed for determination of the beginning of oxides creation and phase detection at different heating temperatures. Scanning electron microscopy fitted with EDX analysis was used for observation of fracture areas and measurements of coatings and oxide layers thicknesses as well. Determination of chemical composition of coatings surfaces and elemental linescans through the coatings and oxide layers were performed using EDX analysis. All measurements of these coatings were carried out not only before but also after the thermal annealing.
Impact of Data Characteristics on Feature Selection Techniques Performance
Authors: Oreski Dijana 
Published: May 2018

Abstract
Feature selection is a step in knowledge discovery in databases which takes away most of the time of the entire process. Therefore, the effective implementation of feature selection significantly improves the overall process. This paper suggests examining data characteristics before applying feature selection and hypothesize that data characteristics significantly affect feature selection techniques performance. Our experimental comparison of five previously used feature selection techniques reveals significant difference in feature selection techniques performance when dealing with data sets of different characteristics
Business Applications Architecture Model Based on Software Product Line Approach
Authors: Roško Zdravko 
Published: May 2018

Abstract
Software product line architecture is one of the most important artifacts defined at the early stage of a product line development process. Since the rest of the products are developed based on the initial product line architecture, it is of high importance to ensure the architecture stability by enabling the software’s evolution possibilities. Industrial evidence shows that companies spend more resources on maintaining and evolving their architecture and products than on the initial development of them. Hence, there is a need for flexible software architecture that stays stable as the requirements evolve. In this paper we propose a structural model, some architecture quality metrics, case-based reasoning methodology to predict the architectural stability and a feature model for business applications. The goal of the proposed architecture model is to develop a framework for business applications development and evaluating the stability of product line architectures in the face of changes in requirements.
Dealing with Mobile Platforms Fragmentation Problem: Ontology Oriented Approach
Authors: Stapić Zlatko 
Published: May 2018

Abstract
The available researches that referred mobile platforms fragmentation problem showed that current solutions, although many, converge into several groups that have common advantages and disadvantages and are based on the same principle: code ones, run anywhere. Thus, the new approach that would enable the developers to use native development environments was necessary. This paper introduces an ontology oriented approach that is based on methodological interoperability. Important assumption of the ongoing research presented in this paper is that during the development process the development team should use the same methodology and the same approach while developing for multiple mobile platforms. This will enhance this process with the artifacts reuse possibility according to the ontologically described knowledge.
The Proposal of the Process of Safety Analysis for Complex Dynamic Technology Systems
Authors: Štrbo Milan , Tanuška Pavol , Gese Augustín 
Published: May 2018

Abstract
The aim of this article is the proposal of process of the safety analysis for complex dynamic systems in process of the proposal of control system for safety-critical processes. The method of safety analysis depends on various safety-critical states of system which are system are controlled by models. We propose to use the method SQMD for modeling these states. This method combines qualitative and quantitative methods of modeling states and takes advantage of both methods. The model of the proposal is shown in the diagram. The article includes detailed description of the tasks for each step of analysis.
Minimum Ignition Temperature of Wood Dust Layers
Authors: Pastier Martin , Tureková Ivana , Turňová Zuzana , Harangozó Jozef 
Published: May 2018

Abstract
Fire characteristic (properties) are used to determine the fire risk and explosion hazard of materials. They are defined as numerical values which describe behavior in the process of burning. They can be determinate by standardized test methods. In this paper is described the most important fire technical characteristic of dust layer (minimum ignition temperature) and the results of standard laboratory method determination for wood dusts, aswell.
The Effect of Waveguide Shapes on the Modal Properties and Amplification Factors
Authors: Čičmancová Lenka , Naď Milan 
Published: May 2018

Abstract
Improving of machining process is one of the most important requirements that are expected from the machining methods. In many machining processes, the positive effects of ultrasound are applied. The performance of these machining systems and quality of machining process depends on the correct design of the individual system elements, mainly waveguide. For the correct functioning of the system, the waveguide must have the required dynamic properties - natural frequencies and amplification factors. The waveguide modal properties (natural frequencies, mode shapes) are determined by the numerical simulations using finite element method (FEM) design procedures. The effect of different waveguide shapes (conical, exponential, catenoidal) and their dimensions on modal properties and amplification factors are presented in this paper.
The Impact of Alignment Condition in the Measuring Plan by Using the Software Calypso on the Repeatability of Measured Values
Authors: Guniš Zdenko , Görög Augustín , Vagovský Juraj 
Published: May 2018

Abstract
The main goal of this publication is to determine the impact of the alignment condition to the repeatability of measured values. In the experimental work were performed four series of measurements, each contains 25 individual measurements on a single component. The component was measured according to the rules for making the comparison of measured values for repeatability. This comparison of measurement results was made by using statistical methods. A given goal was completely fulfilled. Experimental work has shown a dominant impact of the alignment condition on the measured values.
A Study of Haitian Immigrant’s Assimilation to Western Practices of Using the Telephony and Internet Technologies / Proučavanje Asimilacije Imigranata Sa Haitija Na Zapadnjačku Praksu Korišćenja Telefonskih I Internet Tehnologija
Authors: Đokić Borivoje-Boris , Polak Rhonda , Francis Jeanette D. , Mujtaba Bahaudin G. 
Published: May 2018

Abstract
This study examines the relationship between the use of technology to stay connected with home country and culture while adapting and integrating into the host culture. Through a survey the authors probe into how Haitian immigrants living in South Florida with varying levels of contact with their home country acculturate into the receiving society, exploring an increasingly salient experience of contemporary global migrants. Immigration is the experience of acculturation by individuals and the emergence of culturally plural societies, where both immigrants and host country citizens can live together in a positive environment. In this study, we report our exploratory findings and insights from a survey conducted among Haitian immigrants in South Florida area, studying the relationship between the scope of their electronic communication, and their level of integration into the mainstream American culture. Considerable research has been devoted to the understanding of immigration, acculturation and adaptation of adults, but much less has addressed these phenomena among Haitian population in reference to the use of communication technologies to keep in touch with their loved ones overseas and being fully adapted to their host country at the same time, asserting both identities. In other words, to what extend Haitians who wish to have contact with American culture, while maintaining their cultural attributes do so through the Internet and telecommunication technologies.
The objective of this study is to explore the correlation between cultural integration process and the level of Internet and telephony technologies usage among Haitians living in South Florida. The Internet and telephones are a necessity becoming central for one’s knowledge of environment, for the retention of one’s social contacts but also for the organization of one’s life. This is especially true for immigrants who often rely on their new and old social networks in order to adjust to the host country. This study looks at five well understood measures or indicators of the acculturation process, namely language proficiency, language use, length of time in the host culture, age, and peer contact. It also looks at the preferences of Internet related tools to contact friends and relatives both in Haiti and the USA by email, text messaging, and social sites. In our study, highly integrated Haitian immigrants are those who are young, have lived here for a long time, are proficient in Creole and English, speak to friends and relatives in both languages, and spend their free time with both Americans and other Haitians.
Probation Service as Part of Penitentiary System in the Republic of Macedonia / Služba Probacije Као Deo Kazneno-Popravnog Sistema U Republici Makedoniji
Authors: Veljanovska Svetlana 
Published: May 2018

Abstract
The reform of the system of execution of sanctions is anticipated in the part of the reform of the criminal justice system of the Republic of Macedonia. The functional system for implementing sanctions in modern criminal justice systems implies a complex approach in which besides the dimension of punishment, the dimensions of social reintegration and victim protection play an important role. In such a context, the so-called probation system, has been established. Event though such system has not been established in the Republic of Macedonia up to now, its elements are contained in the existing legal framework in the material and procedural provisions. Some solutions of the previous system can be used with the aim to establish continuity on institutional and operational level.The starting point for the establishment of probation begins with amendments to the Criminal Code of 2004, where in the part that refers to criminal sanctions, the following alternative measures were imposed: probation, suspended sentence with supervision, conditional discontinuation of criminal proceedings, community service, court sanctions and house arrest. The probation is primarily directed towards designing and developing the system of regular individualized assessment of perpetrators, assessing the risk of re-offending, identifying objective and subjective reasons for previous criminal activity and enabling people who already served their prison sentence to have an active and meaningful involvement in the community.
Pesquisa da atividade antioxidante do Allium Sativum L. pelo ensaio químico do DPPH e ensaios ex vivo com neutrófilos humanos.
Authors: Fuzzatti Sâmela C. , Da Cruz Andrezza Furquim , Gileno Miriane da Costa 
Published: May 2018

O Allium sativum L detém diversos efeitos biológicos como ação antioxidante, antitrombótica, antifúngica e antibacteriana. Devido às suas atividades terapêuticas, consta na relação de plantas medicinais recomendadas pela ANVISA. Este trabalho objetivou avaliar a ação do Allium sativum L., alho, sobre funções de neutrófilos humanos, inclusive citotoxidade e produção de espécies reativas de oxigênio (EROs) e a pesquisa da atividade antioxidante pelo ensaio químico do DPPH. Durante 72 horas, o alho permaneceu em contato com etanol absoluto e após filtração, diferentes diluições foram preparadas para realização dos ensaios. Realizou-se estudos das propriedades antioxidantes do alho por meio de ensaio com DPPH, teste de viabilidade celular (Azul de Trypan), formação de radical ânion superóxido pelo Teste do Nitro Azul de Tetrazólio (NBT), o efeito no sistema MPO/H2O2 (ensaio com TMB). No experimento realizado com DPPH demonstrou-se o efeito antioxidante do extrato de alho em todas as concentrações estudadas. A avaliação estatística do efeito do alho no sistema MPO/H2O2, através do ensaio com TMB, permitiu demostrar que o Allium sativum L. não inibiu a ação da mieloperoxidase, produzida normalmente, pelos neutrófilos. Desta forma, conclui-se que o extrato de alho demonstrou atividade antioxidante pelo ensaio do DPPH e NBT, inibindo também a produção de radical ânion superóxido, não prejudicou a viabilidade dos neutrófilos humanos e não é inibidor de mieloperoxidase. Outros experimentos são necessários para investigar a ação do extrato de alho sobre a atividade fagocitária dos neutrófilos.
CYTOTOXIC AND MOLECULAR MECHANISMS IN OTOTOXICITY OF CISPLATIN
Authors: Çakır Dilek Ülker , ALTUN Zekiye , OLGUN NUR 
Published: May 2018

Ototoxicity is based on inner ear dysfunction creating hearing loss, balance disorder or both symptoms depending on the drug or chemical agent.
Genetic and nongenetic risk factors, in addition to dose and time, play important roles in cisplatin ototoxicity.Although the changes firstly begin from first line of outer hairy cells on the Corti organ in the inner ear and then progress. Though the effect on the spiral ganglion and stria vascularis in addition to the Corti organ are well-defined, the molecular mechanisms that cause hearing loss are not fully understood. Cellular and molecular mechanisms and particularly apoptotic mechanisms explain cisplatin cytotoxicity leading to cochlea damage. DNA damage induced by cisplatin and ROS production seem to be mainly responsible for cisplatin toxicity.
Children treated with cisplatin are at risk of early or late hearing loss which could affect learning, communication, school performance, social communication and general quality of life. For this reason, many protective agents are used with cisplatin without changing its antitumoral efficiency. Studies of compounds to prevent ototoxicity may provide compounds for use in routine clinical practice and prevent one of the major dose-limiting side effects of cisplatin therapy, which will increase treatment efficacy and improve patient quality of life.
HISTOPATHOLOGICAL CHANGES IN THE STOMACH TISSUE OF RATS FED WITH MUSSELS (Mytilus galloprovincialis)
Authors: GEZEN Mehmet Rıza 
Published: May 2018

Dardanelles is exposed to environmental pollution for many years. The strait is important in terms of fish migration and shellfish farming. Fish and shellfish obtained from the strait is frequently consumed by local people. Mussels serve as useful indicators of temporal trends in environmental quality because they accumulate some contaminants in their tissues at levels many time higher than in the surrrounding water and quickly to changes in contamination. Although there are few data about the toxicity of seafood that is exposed to environmental pollution, there are no animal studies about the gastric toxicity of mussels grown in the Dardanelles. Our previous studies demonstrated that the water and mollusc from certain regions of the Dardanelles contained heavy metal salts. The purpose of the study is to demonstrate the histopathologic changes in the gastric tissues of rats which are fed with mussels that are collected from the Çamburnu region of the Dardanelles. Four groups of rats are included in the study, group 1 (n=6), control group fed with standard rat food, group 2 (n=6), 75% mussels and 25% standard rat food daily, group 3 (n=6), 75% mussels and 25% standard rat food every two days, group 4 (n=6), 75% mussels and 25% standard rat food every three days. After the routine histopathologic processing all gastric tissue samples are evaluated in terms of 8-hydroxy-2' -deoxyguanosine (8-OHdG) immunoreactivity with light microscopy and image analysis software. No histopathologic differences found in standard hematoxylin-eosin (H.E.) stained gastric tissue samples of the control group. In the second and third groups, a small amount of mononuclear cell infiltration was detected. In the fourth group, no significant difference was observed in mononuclear cells. In immunohistochemical staining, 8-OHdG immunoreactivity in gastric epithelial cells. 8-OHdG immunoreactivity was negative in gastric tissues in all groups. There was no statistically significant difference between the groups that were fed every day, every other day and every three days with clam (p>0.05).
SAVAŞIN DEĞİŞEN KARAKTERİ: TEORİ VE UYGULAMADA HİBRİT SAVAŞ
Authors: ÖZER Yusuf 
Published: May 2018

Özet

Barış
zamanı karar vericilerin temel görevi, olası savaşlara karşı hem zihinsel hem
de teknolojik olarak hazır bulunmaktır. Bunun için gelecekteki savaşların nasıl
olacağının tahmin edilmesi öncelikli hedeflerden biri olarak karşımıza
çıkmaktadır. Özellikle 21’inci yüzyılda içerisinde kimlerin yer aldığı ve hangi
teknoloji ile mücadele edildiğinin bilinmediği çatışmalar, yeni savaş
kavramlarını yaratmıştır. Bu makalede, bahse konu savaş kavramlarından birisi
olan hibrit savaş teorisi incelenmiştir. Makalenin temel amacı, savaşın değişen
karakteri doğrultusunda hibrit savaşların özelliklerini incelemek, mantığını
anlamak ve konvansiyonel savaşlardan hangi yönlerde ayrıldığını açıklamaktır.
Bu amaç doğrultusunda öncelikle savaş nedir sorusuna cevap aranmış, hibrit
savaş teorisine temel oluşturan savaş tanımlamaları ele alınmış ve küresel
örnekler verilerek hibrit savaş teorisi açıklanmıştır.
Yıldızlararası Ortamdaki On Farklı HII Bölgesinden Seçilen Hα Tayf Sonuçları
Authors: Şahan Muhittin , Tıraş Halil İbrahim , Bolat Erdinç 
Published: May 2018

Bu
çalışmada, DEFPOS tayfölçeri kullanılarak galaksimizdeki on farklı iyonize
olmuş hidrojen kaynağından (Sh2-108, Sh2-119, Sh2-136, Sh2-206, Sh2-228, IC5146,
IC444, NGC6572, NGC6960 ve NGC7380) elde edilen Ha tayf sonuçlarını vermekteyiz. Ha tayfları yıldızlararası ortamdaki iyonize gazın bazı
fiziksel durumları (parlaklıkları, LSR’a göre hızları ve çizgi genişlikleri
gibi) hakkında detaylı bilgi sağlamaktadır. Bu
tayflardan, yapıların LSR’a göre hızları ve parlaklıkları sırasıyla, Sh2-108
için 28.16 km/s ve 160.48 R, Sh2-119 için 14.40 km/s ve 214.22 R, Sh2-136 için
-20.08 km/s ve 458.63 R, Sh2-206 için -2.82 km/s ve 173.29 R, Sh2-228 için
20.21 km/s ve 163.64 R, IC5146 için -7.87 km/s ve 103.56 R, IC444 için -11.50
km/s ve 318.47, NGC6572 için -13.94 km/s ve 114.51 R, NGC6960 için -5.68 km/s
ve 70.40 R NGC7380 için -47.48 km/s ve 524.271 R olarak bulunmuştur. DEFPOS
tayfölçerinin yayılı iyonize gazın çalışılması için güçlü bir alet olduğuna ve
bu yeni sonuçların literatüre katkı sağlayabileceğine inanmaktayız.
АВТОМАТИЗАЦІЯ ПРОЦЕСУ СТВОРЕННЯ ЕСКІЗІВ НОВИХ МОДЕЛЕЙ ОДЯГУ В УМОВАХ МАЛИХ ПІДПРИЄМСТВ
Authors: Васильковський Д. В. , Цимбал Н. А. 
Published: May 2018

Improvement process of designing new models of women's clothing by automating sketch design in conditions of small sewing enterprises. Analysis of computer graphics programs possibilities; determination of meaningful indicators for determining the suitability of existing software by expert estimation method; approbation of the study results in the conditions of designer workplace. There have been created templates of graphic images of different types of female figures, libraries of modern materials textures, which are most often used for women's clothing manufacture. There has been developed the method of new model sketches creation of women's clothes with the use of figure templates and libraries of materials. An approach is proposed that generalizes and simplifies the process of adaptation of universal computer programs of vector graphics with the needs of automated design of new clothing models There has been developed a methodical support for the use of the universal graphic editor Xara Designer Pro on the AWS of a designer of a small sewing enterprise.