bluuebunny/crossref_metadata_2025_split huggingface dataset:
Churg-Strauss Syndrome Presenting as Acute Necrotizing Eosinophilic Myocarditis: Concise Review of the Literature
Authors: Chaudhry Muhammad Ali , Grazette Luanda , Yoon Andrew , Correa Adrian , Fong Michael W. 
Published: September 2018

Background:Acute eosinophilic myocarditis (EM) is a rare form of heart failure that is characterized by myocardial eosinophilic infiltration usually in association with peripheral eosinophilia. The underlying cause is variable and can include allergic reactions, parasitic infection, idiopathic hypereosinophilic syndrome, malignancy, Loeffler’s syndrome, Churg-Strauss syndrome (CSS), early giant cell myocarditis and malignancy. The course is potentially fatal, and early diagnosis and treatment with steroids is essential.Conclusion:Here, we present an illustrative case of eosinophilic myocarditis secondary to CSS followed by a brief review of epidemiology, pathogenesis, diagnosis and treatment of both disease entities.
Assessment of Sensitivity, Specificity, and Accuracy of Nuclear Medicines, CT Scan, and Ultrasound in Diagnosing Thyroid Disorders
Authors: Bafaraj Saeed Mohammed 
Published: September 2018

Purpose:
The study aims to investigate the specificity, sensitivity, and accuracy of nuclear
medicine, CT scan, and ultrasonography to diagnose the disorders related to the thyroid
gland.

Methodology:
The study is based on the retrospective approach of recruiting 52 patients suffering
from thyroid disorders. The demographic details of each patient have been recorded. Moreover, the
results of previously conducted nuclear medicine scan, CT scan, and ultrasound have also been assessed.
The findings of all the tests have been compared to evaluate and compare their sensitivity,
specificity, and accuracy.

Results:
A total of 52 patients were recruited for the study among which 41 were female and 11
were males. The findings of SPECT and MRI were compared, which revealed that MRI possessed
38.8% sensitivity and 22.22% specificity. As compared to the findings of CT scan, increased specificity
(71.42%) and sensitivity (70.96%) have been identified in MRI.

Conclusion:
There is an increase in the sensitivity and specificity of MRI outcomes as compared to
the nuclear medicine and CT scan.
Xanthone Conjugated Amino Acids as Potential Anticancer and DNA Binding Agents: Molecular Docking, Cytotoxicity and SAR Studies
Authors: Rakesh Kadallipura P. , Darshini Nanjudappa , Manukumar Honnayakanakalli M. , Vivek Hamse K. , Eissa Mohammed Y.H. , Prasanna Doddakunche S. , Mallesha Ningegowda 
Published: September 2018

Background:
Amino acids conjugated with heterocyclic molecules are well known for their effective
bioactive properties. In search of effective anticancer agents, a series of xanthone linked amino acids 2-23 were
synthesized and tested for in vitro anticancer activity.

Methods:
In vitro anticancer activity of the synthesized xanthone linked amino acids 2-23 are tested against three
different cancer cell lines MCF-7, MDA-MB-435 and A549 by MTT assay and validated by DNA binding and
molecular docking approaches. Doxorubicin and ethidium bromide used as standard and positive control
respectively.

Results:
Compounds 7, 8 and 9 exhibited potent anticancer activity against tested cancer cell lines and DNA binding
study using methyl green. In the molecular docking study, binding interactions of the most active compounds 7, 8
and 9 were confirmed to molecular surface of DNA.

Conclusion:
Structure-Activity Relationship (SAR) showed that the aromatic and hydrophobic amino acids
(phenylalanine, tyrosine, and tryptophan) favoured the DNA binding studies and anticancer activity whereas,
aliphatic amino acids showed least anticancer activity.
REPENSAR DIREITOS HUMANOS
Authors: Prado Rebeca Makowski 
Published: September 2018

David Sánchez Rubio, professor titular de Filosofia do Direito da Faculdade de Direito da Universidade de Servilha, Espanha, seguindo os passos de seu mestre, professor Joaquín Herrera Flores, escreve uma carreira acadêmica matizada por perpesctiva crítica, plural e emancipadora, delineada por uma atuação engajada e observável em sua produção teórica, cuja compreensão do Direito é apresentada como instrumento libertário (inspirada em Enrique Dussel). Precioso destacar que Sànchez Rubio, apesar de nativo europeu, filia-se a correntes de pensamento latino-americanas tal qual Helio Gallardo.
FUNÇÃO SOCIAL DA EMPRESA. ANÁLISE PRAGMÁTICA - FUNCTION OF THE COMPANY. PRAGMATIC ANALYSIS
Authors: Mendonça Saulo Bichara 
Published: September 2018

Para o direito o empresário representa um ser sem definição positivada, mas pragmaticamente pode ser reconhecido pelos contornos funcionais que o cotidiano lhe delineia, amplamente confirmados pelas concepções doutrinárias e jurisprudenciais. Não obstante, a empresa enquanto atividade desenvolvida pelo empresário possui responsabilidades das mais relevantes; sendo exigível de forma efetiva a comprovação de sua função social, que por óbvio, não se confunde com suas responsabilidades sociais. Destarte, neste esboço, a investigação registrará seu foco na colisão entre as múltiplas variáveis com que a atividade empresária se vincula de forma positivada, em vários ramos do direito e a importância de se registrar o desenvolvimento da função social, embasando-se por oportuno na perspectiva econômica do direito, sustentando-se no alicerce sobre o qual a empresa que não registre o cumprimento de tal função, poderia até honrar com suas variáveis, mas encontrar-se-ia vazia de legitimidade socioeconômica, passível, portanto de representar ônus ao Estado. For the law is the entrepreneur represents an be undefined positivism, but pragmatically it can be recognized by the functional shape delineates his daily life, amply confirmed by the doctrinal and jurisprudential concepts. Nevertheless, the company while activity developed by the entrepreneur has the most important responsibilities, being effectively required to prove its social function, which obviously, can not be confused with their social responsibilities. Thus, in this sketch, register its research focus in the collision between multiple variables with the activity entrepreneur is linked so positivity in various branches of law and the importance of recording the development of social function, basing itself on appropriate in view economic law, underpinned by the foundation on which the company did not record the performance of that function, it might honor with its variables, but finding it would empty of socioeconomic standing, liable, so the burden of representing the State.
O DIREITO TRANSNACIONAL E A FORMAÇÃO DE NOVAS FORMAS DE PODER EM UMA SOCIEDADE DE CONTROLE INFORMACIONAL
Authors: Rodrigues Márcia Sleiman , Pinto Augusto Eduardo Miranda 
Published: September 2018

O presente trabalho analisa as implicações das tecnologias digitais na constituição de uma nova sociedade de controle e seus efeitos na formação de um direito supranacional. Passamos de uma sociedade disciplinar hermética, fechada para uma sociedade de controle fluídica e aberta, mas continuamos com a mesma sistemática, utilizando outros instrumentos. Esse modelo impõe através de uma relação hierárquica um comportamento a uma multiplicidade de indivíduos, criando um encarceramento perfeito através do exercício do biopoder. Tais papéis são reforçados pela cultura consumista e a sociedade do espetáculo que transforma o indivíduo em uma mercadoria, levantando perfis de usuários conectados em rede propiciando uma categorização dos consumidores e trabalhadores com o objetivo de otimizar o lucro. Esta nova ordem permeia toda a civilização em um espaço ilimitado, universal com a apresentação de uma noção de direito atemporal, unitário com um centro de comando absoluto, que vise à paz perpétua e a justiça para todos. Essa utopia, que se propõe a ocupar todo o espaço sistêmico de maneira totalizante tem seu contraponto na formação de um proletariado que aparece como um novo poder, podendo através da linguagem e da comunicação interativa constituir uma estrutura corporativa necessária para a sua libertação. Com um novo uso da ligação maquinal em rede como ferramenta biopolítica, atua como um agente autônomo da produção. Nesta sociedade de controle informatizada criadora de condutas discriminatórias, a ‘multidão’ resgata sua identidade própria e toma de seus controladores o direito de fazer sua própria história coletiva.
Correlation between total pressure losses of highly loaded annular diffusers and integral stage design parameters
Authors: Mimic Dajan , Jätz Christoph , Herbst Florian 
Published: September 2018

Diffusers convert kinetic flow energy into a rise in static pressure. This pressure recovery is the primary aerodynamic design objective for exhaust gas diffusers in power-generating steam and gas turbines. The total pressure loss is an equally important diffuser design parameter. It is strongly linked to the pressure recovery and the residual kinetic energy of the diffuser outlet flow. A reduction benefits the overall thermodynamic cycle, which requires the adjacent components of a diffuser to be included in the design process.
This paper focuses on the total pressure losses in the boundary layer of a highly loaded annular diffuser. Due to its large opening angle the diffuser is susceptible to flow separation under uniform inlet conditions, which is a major source for total pressure losses. However, the unsteady tip leakage vortices of the upstream rotor, which are a source of losses, stabilise the boundary layer and prevent separation. Experiments and unsteady numerical simulation conducted show that the total pressure loss reduction caused by the delayed boundary layer separation exceed the vortex-induced losses by far. This flow interaction between the rotor and diffuser consequently decreases the overall total pressure losses.
The intensity of the tip leakage vortex is linked to three rotor design parameters, namely work coefficient, flow coefficient and reduced blade-passing frequency. Based on these parameters, we propose a semi-empiric correlation to predict and evaluate the change in total pressure losses with regards to design operating conditions.
A Legal and Exploratory Empirical Analysis of Changes to Innocent Spouse Law
Authors: Plečnik James M. 
Published: September 2018

ABSTRACT
This paper studies recent changes to innocent spouse law instituted by Rev. Proc. 2013-34. This rule change explicitly addresses issues with innocent spouse rulings, while also making innocent spouse law more flexible. I use legal and empirical methodologies to study 81 innocent spouse cases, and find that the recent rule changes have significantly modified the impact of various factors. Changes to some factors were stated objectives of the rule change; for example, abuse now has an increased impact on innocent spouse rulings. However, some changes appear to be side effects of the revised law's increased flexibility. Specifically, the health factor was unchanged by Rev. Proc. 2013-34, but appears to have gained prominence due to greater flexibility in innocent spouse law. Overall, my findings show that judges can now decide a case based on various criteria, rather than being bound primarily by taxpayer knowledge—as was the case pre-Rev. Proc. 2013-34.
Association of tibial plateau leveling osteotomy with proximal tibial osteosarcoma in dogs
Authors: Selmic Laura E. , Ryan Stewart D. , Ruple Audrey , Pass William E. , Withrow Stephen J. 
Published: September 2018

Abstract
OBJECTIVE To assess for any association between a history of tibial plateau leveling osteotomy (TPLO) and subsequent development of proximal tibial osteosarcoma in dogs.
DESIGN Matched case-control study.
ANIMALS 34 client-owned dogs in which proximal tibial osteosarcoma was diagnosed between January 2005 and December 2012 (cases) and 79 dogs without osteosarcoma, matched 3:1 to cases (when possible) by age, breed, and initial examination date (controls).
PROCEDURES Information on each case and control was collected from the medical records and other sources regarding date of birth, sex and neuter status, body weight, breed, and whether TPLO had been performed ≥ 1 year ago. A multivariable conditional logistic regression model was constructed to evaluate associations of body weight and history of TPLO with the outcome of proximal tibial osteosarcoma in dogs.
RESULTS After adjusting for body weight in the multivariable model, dogs with a history of TPLO were 40 times as likely to develop proximal tibial osteosarcoma as were dogs with no history of TPLO. In addition, each 1-kg (2.2-lb) increase in body weight was associated with an 11% increase in the odds of proximal tibial osteosarcoma.
CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that dogs with a history of TPLO were at increased risk of developing osteosarcoma of the proximal region of the tibia relative to dogs with no such history. Therefore, it is important for proximal tibial osteosarcoma to be included among the differential diagnoses for new or worsening hind limb lameness in dogs that underwent TPLO ≥ 1 year previously.
Clinical features, diagnostic methods, treatments, and outcomes associated with ingested wires in the abdomen of horses: 16 cases (2002–2013)
Authors: Marley Laura K. , Soffler Carl , Hackett Eileen S. 
Published: September 2018

Abstract
OBJECTIVE To describe clinical features, diagnostic methods, treatments, and outcomes associated with ingested wire foreign bodies in the abdomen of horses.
DESIGN Retrospective case series.
ANIMALS 16 client-owned horses with ingested wire in their abdomens that were evaluated at a veterinary teaching hospital between April 2002 and February 2013.
PROCEDURES Data for each case were collected from medical records and owners and then reviewed. Differences in clinicopathologic variables between horses that did (survivors) or did not (nonsurvivors) survive to discharge from the hospital were assessed.
RESULTS The median duration of clinical signs prior to admission was 5.5 days (range, 0.5 to 1,095 days). Survivors (n = 4) had significantly lower median WBC count, neutrophil count, and plasma total protein concentration, compared with nonsurvivors (12), and all survivors underwent surgical treatment. Peritoneal fluid analysis revealed suppurative or septic peritonitis in all 8 horses tested. The presence of wire was confirmed by abdominal radiography (n = 6), exploratory laparotomy (2), and necropsy (8). The median length of ingested wire was 6 cm; wire had perforated viscera in 13 horses, 10 of which subsequently developed abdominal abscesses.
CONCLUSION AND CLINICAL RELEVANCE Abdominal perforation by wire should be considered a differential diagnosis for horses with peritonitis and abdominal abscesses. Radiography is useful for detection of wire foreign bodies in the abdomens of horses. Given the guarded prognosis for affected horses suggested by results of the present study, early and aggressive treatment, including exploratory laparotomy to retrieve the wire and address perforations, peritonitis, and abscesses, should be considered.
“Footprint”: The Apocalyptic Imprint of End as Immanent in Atwood’s Oryx and Crake
Authors: Dillon Denise B. 
Published: September 2018

In her speculative fiction novel, Oryx and Crake, Atwood explores and challenges readers with visions of loss: the extinction of life forms, of culture, and loss of human control over various systems including those of language, economy and ecology. All such systems are prone to human manipulative influence and sensitive to minor alterations that result in major disruptions and ultimately to extinction, disappearance (both forms of loss) or, at best, altered forms of survival. I consider here McKibben’s suggestion that we live in a “postnatural world” because human activity has altered things as fundamental as the weather, and explore Atwood’s depiction of some of the consequences of a human-altered future in which a great city transforms into a harsh, tropical wilderness. I also apply Buell’s notion that apocalyptic rhetoric serves to alert people to global environmental threats by arousing their imagination to a “sense of crisis,” through this “master metaphor”. If only perceptions to threats are sufficiently aroused such that people are spurred to action, real apocalypse might thereby be delayed. Buell expresses the view that the environmental imagination has a sure role in how people might be able to adapt to transformations in the environment by gaining understanding of what the human relation to nature can be and what it should be. The notion of apocalypse is a strong and enduring theme in literature and is of particular relevance to speculative fiction pertaining to human desire to exercise ultimate control, as is Oryx and Crake.
Cómo llegar a ser un buen cirujano colorrectal.
Authors: Garcia Olmo Damián 
Published: September 2018

Mamá (papá), ¿por qué elegiste esta especialidad? La pregunta se repite en los hogares de los cirujanos colorrectales en algún momento de la vida de familia. Es una buena pregunta porque nos pone delante de la peculiaridad que significa ser cirujano colorrectal. Se trata de una especialidad que se ocupa de la cirugía del colon, recto y ano. Esto es, de todo lo relacionado en el cuerpo humano con los residuos más escatológicos que se acumulan en el tramo final del tubo digestivo, ahora denominados “microbiota”. Sin duda esto hace que el “bouquet” de la especialidad esté un tanto señalado.
Adenocarcinoma en el seno de fístula perianal en enfermedad de Crohn
Authors: Maldonado Valdivieso Patricia , Rodríguez Martín Marcos 
Published: September 2018

Se trata de un paciente de 40 años de edad con enfermedad de Crohn de larga evolución, diagnosticada hace 19 años. El paciente ha precisado múltiples ingresos y resección de setenta centímetros de intestino delgado por afectación inflamatoria refractaria al tratamiento médico. Presenta además enfermedad fistulosa perianal con fístulas extraesfintéricas complejas y afectación mayoritaria del glúteo derecho hacia la base testicular y raíz del muslo derecho. Ha requerido fistulotomías parciales y colocación de múltiples setones.
Síndrome de Mc Kittrick Wheelock como presentación clínica de adenoma velloso de recto de gran tamaño.
Authors: Tortolero Giamate Laura María , Luengo Pierrard Patricia 
Published: September 2018

Varón de 58 años que acude al Servicio de Urgencias por cuadro de deterioro progresivo del estado general, caracterizado por astenia, calambres musculares, palpitaciones y polidipsia intensa. Refiere un síndrome diarreico con moco, intermitente, de 1 año de evolución, que le genera debilidad. Incremento en el número y volumen de las deposiciones en los últimos 4 días.
Eşme Ayva (Cydonia oblonga Mill.) Çeşidinde Optimum Derim Tarihini Belirlemek İçin Uygun Kriterlerin Seçimi
Authors: Çalhan Özgür , Koyuncu Mehmet Ali 
Published: September 2018

Meyvelerde optimum derim zamanı (ODZ) belirlenmesi derim öncesi ve
sonrası dönemde meyve kalitesinin korunması ve kayıpların azaltılması için en
önemli faktörlerin başında gelmektedir. Bu çalışmada, Türkiye’de en yoğun
yetiştirilen Eşme ayva çeşidinde ODZ için uygun kriterlerin belirlenmesi
amaçlanmıştır. Bu amaçla 2 yıl süresince, küçük meyve döneminden derim tarihi
sonrasına kadar haftalık periyodlarla ağaçlardan meyve örnekleri alınarak
analizler yapılmıştır. Meyvelerde tam çiçeklenmeden derime kadar geçen gün
sayısı (TÇDG), meyve ağırlığı, meyve en ve boy gelişimi, nişasta parçalanması,
meyve eti sertliği, suda çözünür kuru madde miktarı, pH, titre edilebilir
asitlik, meyve kabuk rengi, etilen üretimi ve solunum hızı ölçümleri
yapılmıştır. Eşme ayva çeşidinde ODZ’nin
belirlenmesinde en kullanışlı kalite parametreleri olarak TÇDG, meyve kabuk
rengi (h° değeri), sertlik ve nişasta içeriği ön plana çıkmıştır. Meyvelerin
erken, optimum ve geç dönemde derimi için sırasıyla TÇDG sayısı 150-155 gün,
155-165 gün, 165-175 gün; kabuk renk skalası değeri 5-6, 7, 8; kabuk rengi h°
değeri 115°-110°, 110°-105°, 105°-100°, meyve eti sertliği 85-90 N, 75-80 N,
70-75 N; nişasta skalası değeri 4-5, 6, 7 olarak belirlenmiştir.
Representações sociais de futuros docentes sobre a teoria da evolução darwinista
Authors: Magalhães Fernanda Cândido 
Published: September 2018

A teoria da evolução de Darwin, que apresenta ampla repercussão nos conhecimentos de senso comum, é o objeto desse estudo do campo representacional. Para interpretação dos dados utilizou-se a Teoria das Representações Sociais, de Moscovici. O método de coleta de dados consistiu no levantamento da estrutura das representações sociais sobre a Teoria da Evolução, entre 179 estudantes dos cursos de graduação de Pedagogia e Biologia. O estudo apontou forte ligação entre a Teoria da Evolução e a imagem de Darwin. Mesmo com o passar de 150 anos teoria e autor estão presentes no conhecimento popular, rompendo as barreiras do universo científico para circular amplamente nas representações desses futuros professores.
Contoured Loop and Modified Wiring Technique for occipitocervical Fixation - A Safe and Efficacious Option
Authors: Shrestha Shikher , Bishokarma Suresh , Devkota Upendra Prasad 
Published: September 2018

To study the safety and efficacy of contoured loop and modified wiring techniques for occipitocervical fixation. Retrospective study among 15 patients who underwent occipitocervical fixation from Jan 2011-16 were reviewed. Contoured loop was wired at 2 points in occiput and 4 different points, 2 on either side to percutaneously passed K wire through the spino laminar junctions of C2 and C3. Additional fusion with on lay autologous graft from either iliac crest or ribs was done. Various parameters studied were patient’s demography, causes of instability, change in neurological function, complications and radiographic outcome. Six had basilar in vagination, 4 had traumatic atlantoaxial subluxation, 4 had osodontoidium and 1 had Rheumatoid arthropathy. There was improvement in Frankel grade from C to D in 6 and from D to E in 5 patients. Radiological union at 6 months was observed in all 15 cases. Two patients had surgical site infection. Dislodgement of K wire was found in 4 cases (26.66%) by which time radiological union had already taken place. The approximate cost of instrumentation was 100 dollars for each patient.Conclusions. Contoured rod and modified wiring occipitocervical fixation technique are relatively a safe, cheap and technically easy alternative for the management of occipitocervical instability.