bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review of the evolution of robotic-assisted total hip arthroplasty
Authors: Subramanian Padmanabhan , Wainwright Tom W , Bahadori Shayan , Middleton Robert G 
Published: April 2019

Introduction: Total hip arthroplasty (THA) is currently a very successful operation but continues to evolve as we try to perfect techniques and improve outcomes for our patients. Robotic hip surgery (RHS) began with the ‘active’ ROBODOC system in the 1980s. There were drawbacks associated with the original ROBODOC and most recently, the MAKO robot was introduced with early promising results. Aim: The aim of this paper is to provide an up-to-date review surrounding this area and discuss the pros and cons of this technique. Methods: A literature review searching Medline, Embase, Ovidsp, Cochrane library, pubmed database and google scholar was performed searching keywords including: ‘Robotic hip surgery’, ‘Robotic orthopaedic surgery’, ‘Computer assisted hip surgery’, ‘robotic arthroplasty’, and ‘computer assisted orthopaedic surgery’. Conclusion: Robotic hip surgery aims to tackle the limitations of the human factor in surgery by promising reproducible and reliable methods of component positioning in arthroplasty surgery. However, as orthopaedic surgeons, we must critically appraise all new technology and support the use providing there is sound robust evidence backing it.
Efficacy of direct oral anticoagulants on the resolution of left ventricular thrombus—A case series and literature review
Authors: Bahmaid Reem A , Ammar Shoroq , Al-Subaie Sarah , Soofi Mohammed A , Mhish Hassan , Yahia Madonna Ali 
Published: April 2019

Background Left ventricular thrombus is a frequent complication of acute myocardial infarction and a risk factor for thromboembolic complications. Warfarin has been frequently used, but has some disadvantages that limit its use. Direct oral anticoagulants, in particular Dabigatran and Rivaroxaban have been proved to be effective in preventing thromboembolism among patients with non-valvular atrial ﬁbrillation. However, no randomized clinical trials testing the efficacy and safety of these agents in patients with existing left ventricular thrombus. Furthermore, direct oral anticoagulants are still not approved by the Food and Drug Administration in the management of left ventricular thrombus. Method This study was a retrospective cohort assessing the efficacy of direct oral anticoagulants (Dabigatran or Rivaroxaban) on the resolution of left ventricular thrombus in patients taking either of these drugs during the study period from December, 2011 to December, 2016 at King Fahad Medical City. All patients’ records were reviewed and all patients who were diagnosed with left ventricular thrombus were included. Patients without available echocardiogram records were excluded. The study was approved by the institutional review board of King Fahad medical city, Riyadh Saudi Arabia. Result During the defined study period we found that 413 and 1218 patients were taking Dabigatran and Rivaroxaban, respectively. After filtering them based on the specialty of the prescriber, we ended up with 299 patients who have been started on Dabigatran and 448 patients who have been started on Rivaroxaban by cardiologists. Moreover, after reviewing echocardiogram reports for all of them (747 patients), we found that 11 patients were diagnosed to have left ventricular thrombus. Among those 11 patients, seven of them were treated with direct oral anticoagulants from the beginning and the remaining four patients were shifted from Warfarin to direct oral anticoagulants. All of them (7 patients) showed left ventricular thrombus resolution on follow-up echocardiogram. Conclusion Use of direct oral anticoagulants showed promising results in the resolution of left ventricular thrombus in patients diagnosed with left ventricular thrombus. Further studies at multiple health care centers are needed to further evaluate the efficacy and safety of direct oral anticoagulants as compared to traditional treatment in patients with left ventricular thrombus.
Characteristics of Emergency Department Visits and Select Predictors of Hospitalization for Adults With Newly Diagnosed Cancer in a Safety-Net Health System
Authors: Hong Arthur S. , Sadeghi Navid , Harvey Valorie , Lee Simon Craddock , Halm Ethan A. 
Published: April 2019

PURPOSE: There is little description of emergency department (ED) visits and subsequent hospitalizations among a safety-net cancer population. We characterized patterns of ED visits and explored nonclinical predictors of subsequent hospitalization, including time of ED arrival. PATIENTS AND METHODS: This was a retrospective cohort study of patients with cancer (excluding leukemia and nonmelanoma skin cancer) between 2012 and 2016 at a large county urban safety-net health system. We identified ED visits occurring within 180 days after a cancer diagnosis, along with subsequent hospitalizations (observation stay or inpatient admission). We used mixed-effects multivariable logistic regression to model hospitalization at ED disposition, accounting for variability across patients and emergency physicians. RESULTS: The 9,050 adults with cancer were 77.2% nonwhite and 55.0% female. Nearly one-quarter (24.7%) of patients had advanced-stage cancer at diagnosis, and 9.7% died within 180 days of diagnosis. These patients accrued 11,282 ED visits within 180 days of diagnosis. Most patients had at least one ED visit (57.7%); half (49.9%) occurred during business hours (Monday through Friday, 8:00 am to 4:59 pm), and half (50.4%) resulted in hospitalization. More than half (57.5%) of ED visits were for complaints that included: pain/headache, nausea/vomiting/dehydration, fever, swelling, shortness of breath/cough, and medication refill. Patients were most often discharged home when they arrived between 8:00 am and 11:59 am (adjusted odds ratio for hospitalization, 0.69; 95% CI, 0.56 to 0.84). CONCLUSION: ED visits are common among safety-net patients with newly diagnosed cancer, and hospitalizations may be influenced by nonclinical factors. The majority of ED visits made by adults with newly diagnosed cancer in a safety-net health system could potentially be routed to an alternate site of care, such as a cancer urgent care clinic.
Delayed Puberty—Phenotypic Diversity, Molecular Genetic Mechanisms, and Recent Discoveries
Authors: Howard Sasha R , Dunkel Leo 
Published: April 2019

AbstractThis review presents a comprehensive discussion of the clinical condition of delayed puberty, a common presentation to the pediatric endocrinologist, which may present both diagnostic and prognostic challenges. Our understanding of the genetic control of pubertal timing has advanced thanks to active investigation in this field over the last two decades, but it remains in large part a fascinating and mysterious conundrum. The phenotype of delayed puberty is associated with adult health risks and common etiologies, and there is evidence for polygenic control of pubertal timing in the general population, sex-specificity, and epigenetic modulation. Moreover, much has been learned from comprehension of monogenic and digenic etiologies of pubertal delay and associated disorders and, in recent years, knowledge of oligogenic inheritance in conditions of GnRH deficiency. Recently there have been several novel discoveries in the field of self-limited delayed puberty, encompassing exciting developments linking this condition to both GnRH neuronal biology and metabolism and body mass. These data together highlight the fascinating heterogeneity of disorders underlying this phenotype and point to areas of future research where impactful developments can be made.
The chromodomain helicase CHD4 regulates ERBB2 signaling pathway and autophagy in ERBB2+ breast cancer cells
Authors: D'Alesio Carolina , Bellese Grazia , Gagliani Maria Cristina , Lechiara Anastasia , Dameri Martina , Grasselli Elena , Lanfrancone Luisa , Cortese Katia , Castagnola Patrizio 
Published: April 2019

The chromodomain helicase DNA-binding 4 (CHD4), a member of the nucleosome remodeling and deacetylases (NuRD) complex, has been identified as an oncogene that modulates proliferation and migration of breast cancers (BC). ERBB2 is an oncogenic driver in 20-30% of BC in which its overexpression leads to increased chemoresistance. Here we investigated whether CHD4 depletion affects the ERBB2 cascade and autophagy, which represents a mechanism of resistance against Trastuzumab (Tz), a therapeutic anti-ERBB2 antibody.
We show that CHD4 depletion in two ERBB2+ BC cell lines strongly inhibits cell proliferation, induces p27KIP1 upregulation, Tyr1248 ERBB2 phosphorylation, ERK1/2 and AKT dephosphorylation, and downregulation of both ERBB2 and PI3K levels. Moreover, CHD4 silencing impairs late stages of autophagy, resulting in increased levels of LC3 II and SQSTM1/p62, lysosomal enlargement and accumulation of autolysosomes (ALs). Importantly, we show that CHD4 depletion and concomitant treatment with Tz prevent cell proliferation in vitro. Our results suggest that CHD4 plays a critical role in modulating cell proliferation, ERBB2 signaling cascade and autophagy and provide new insights on CHD4 as a potential target for the treatment of ERBB2+ BC.
Approximate Solution and its Convergence Analysis for Hypersingular Integral Equations
Authors: Sharma Vaishali , Setia Amit 
Published: April 2019

This paper propose a residual based Galerkin method with Legendre polynomial as a basis functions to find the approximate solution of hypersingular integral equations. These equations occur quite naturally in the field of aeronautics such as problem of aerodynamics of flight vehicles and during mathematical modeling of vortex wakes behind aircraft. The analytic solution of these kind of equations is known only for a particular case ( m(x,t) =0 in Eqn (1)). Also, in these singular integral equations which occur during the formulation of many boundary value problems, the known function m(x,t) in (Eqn (1)) is not always zero. Our proposed method find the approximate solution by converting the integral equations into a linear system of algebraic equations which is easy to solve. The convergence of sequence of approximate solutions is proved and error bound is obtained theoretically. The validation of derived theoretical results and implementation of method is also shown with the aid of numerical illustrations.
Strong approximation inh-mass of rectifiable currents under homological constraint
Authors: Chambolle Antonin , Ferrari Luca Alberto Davide , Merlet Benoit 
Published: April 2019

AbstractLeth:ℝ→ℝ+{h:\mathbb{R}\to\mathbb{R}_{+}}be a lower semicontinuous subbadditive and even function such thath⁢(0)=0{h(0)=0}andh⁢(θ)≥α⁢|θ|{h(\theta)\geq\alpha|\theta|}for someα>0{\alpha>0}. IfT=τ⁢(M,θ,ξ){T=\tau(M,\theta,\xi)}is ak-rectifiable chain, itsh-mass is defined as𝕄h⁢(T):=∫Mh⁢(θ)⁢𝑑ℋk.\mathbb{M}_{h}(T):=\int_{M}h(\theta)\,d\mathcal{H}^{k}.Given such a rectifiable flat chainTwith𝕄h⁢(T)<∞{\mathbb{M}_{h}(T)<\infty}and∂⁡T{\partial T}polyhedral, we prove that for everyη>0{\eta>0}, it decomposes asT=P+∂⁡V{T=P+\partial V}withPpolyhedral,Vrectifiable,𝕄h⁢(V)<η{\mathbb{M}_{h}(V)<\eta}and𝕄h⁢(P)<𝕄h⁢(T)+η{\mathbb{M}_{h}(P)<\mathbb{M}_{h}(T)+\eta}. In short, we have a polyhedral chainPwhich strongly approximatesTinh-mass and preserves the homological constraint∂⁡P=∂⁡T{\partial P=\partial T}. Whenh′⁢(0+){h^{\prime}(0^{+})}is well defined and finite, the definition of theh-mass extends as a finite functional on the space of finite massk-chains (not necessarily rectifiable). We prove in this case a similar approximation result for finite massk-chains with polyhedral boundary. These results are motivated by the study of approximations of𝕄h{\mathbb{M}_{h}}by smoother functionals but they also provide explicit formulas for the lower semicontinuous envelope ofT↦𝕄h⁢(T)+𝕀∂⁡S⁢(∂⁡T){T\mapsto\mathbb{M}_{h}(T)+\mathbb{I}_{\partial S}(\partial T)}with respect to the topology of the flat norm.
Bedeutung und Potenzial von Geoinformationen und deren Anwendungen im Kontext von Bibliotheken und digitalen Sammlungen
Authors: Müller Friedrich , Schmunk Stefan 
Published: April 2019

ZusammenfassungIn den letzten Jahren ist ein gesteigerter Bedarf vieler Fachdisziplinen an bereitgestellten Geoinformationen und Forschungsanwendungen mit GIS-Komponente(n) zu verzeichnen. Im Hinblick auf die digitale Transformation von Bibliotheken und den damit verbundenen fortschreitenden technischen und informationswissenschaftlichen Möglichkeiten wie Methoden des Text und Data Mining stehen zudem viele raumzeitliche Informationen in Bibliotheken zur Verfügung. In diesem Kontext gibt dieser Artikel einen exemplarischen Überblick über bereits vorhandene Entwicklungen in Bibliotheken weltweit, nennt Perspektiven der Erschließung und Nutzung von Geoinformationen für einen gewinnbringenden, zukunftsorientierten Einsatz und zeigt auf, welche Komponenten und Services in Zukunft von Bibliotheken angeboten werden könnten.
abiLehre.com: Wissensvermittlung mit Nachhaltigkeit
Authors: Feitsch Nathalie , Habermayer Andreas 
Published: April 2019

ZusammenfassungDie Webseite abiLehre.com repräsentiert den in Österreich angebotenen Lehrberuf Archiv-, Bibliotheks- und Informationsassistent und wurde eigeninitiativ von zwei Absolventen im Jahr 2016 ins Leben gerufen. Diese Plattform unterstützt Auszubildende und Absolventen und bietet ein sehr breites Angebot an allgemeinen und fachbezogenen Informationen für alle Interessenten.
Synergieeffekte durch Kooperation: Hintergründe, Aufgaben und Potentiale des Projekts FoDaKo
Authors: Hess Volker , von Rekowski Thomas , Roller Sabine , Walger Nicole 
Published: April 2019

ZusammenfassungVor dem Hintergrund der zunehmenden Bedeutung von Open-Data-Ansätzen und neuen Anforderungen an das Forschungsdatenmanagement (FDM) vonseiten der Förderinstitutionen, streben Forschende und Institutionen einen Wandel bislang praktizierter Vorgehensweisen beim FDM an. In einer universitären Kooperation von drei Rechenzentren und drei Universitätsbibliotheken zielt das Projekt Forschungsdatenmanagement in Kooperation (FoDaKo)Rekowski und Hess (2017), FoDaKo Forschungsprojekt. darauf ab, Synergien nutzbar zu machen und Best Practices für das FDM zu entwickeln und auszutauschen. Der Beitrag gibt einen Einblick in Struktur, Maßnahmen und bislang gesammelte Erfahrungen eines Projekts zur Erforschung des Managements von Forschungsdaten in ihrem Lebenszyklus an den Universitäten Düsseldorf, Siegen und Wuppertal und ermöglicht Dritten damit die Adaption von Ansätzen für ein möglichst kosteneffizientes und nachhaltiges FDM.
Library life in Australia: It Has Been a Busy Year!
Authors: Hallam Gillian 
Published: April 2019

AbstractThe strength and vibrancy of the Australian library sector is explored in this article. The concepts of developing, i.e. growing and maturing as an industry, and sustaining, i.e. supporting and maintaining the quality of library services, thread through the discussions about the events and activities that have shaped the library profession, library advocacy initiatives and the future generation of librarians.
Redaktionssache Forschungsdaten
Authors: Cremer Fabian , Klaffki Lisa , Steyer Timo 
Published: April 2019

ZusammenfassungDer Beitrag fokussiert die Publikation von Forschungsdaten in den Geisteswissenschaften und vertritt die These, dass die Forschungsdatenpublikation im Wissenschaftsbetrieb als Dienstleistung realisierbar ist. Ausgehend von hinderlichen Barrieren im System und förderlichen Modellen in Verbundprojekten wird das Konzept der Forschungsdatenredaktion diskutiert. Dieses Konzept basiert auf einer redaktionellen Bearbeitung der Forschungsdaten nach dem Forschungsprozess und der Veröffentlichung als eigenständiger Publikationsform.
PARTHENOS – Eine digitale Forschungsinfrastruktur für die Geistes- und Kulturwissenschaften
Authors: Wuttke Ulrike , Spiecker Claus , Neuroth Heike 
Published: April 2019

ZusammenfassungDas EU-geförderte Projekt PARTHENOS steht für „Pooling Activities, Resources and Tools for Heritage E-research Networking, Optimization and Synergies“ und arbeitet an der Verbesserung der Nutzung von digitalen Forschungsinfrastrukturen in den Geistes- und Kulturwissenschaften. Der Artikel stellt die Projektergebnisse der letzten drei Jahre, die sich auf eine technische und semantische Harmonisierung der verschiedenen bereits existierenden digitalen Forschungsinfrastrukturen, wie z. B. DARIAH, CLARIN etc. konzentrieren, vor. Darüber hinaus hat das Projekt zum Ziel, durch spezifische Trainings- und Schulungsmaßnahmen weitere Forschende der EU an die Digital Humanities, deren Methoden und digitalen Dienste heranzuführen. Ein besonderer Fokus liegt dabei auch auf der Sensibilisierung für die Themen Open Science, FAIR und Forschungsdatenmanagement.
Short-Run Health Consequences of Retirement and Pension Benefits: Evidence from China
Authors: Nikolov Plamen , Adelman Alan 
Published: April 2019

Abstract
This paper examines the impact of the New Rural Pension Scheme (NRPS) in China. Exploiting the staggered implementation of an NRPS policy expansion that began in 2009, we use a difference-in-difference approach to study the effects of the introduction of pension benefits on the health status, health behaviors, and healthcare utilization of rural Chinese adults age 60 and above. The results point to three main conclusions. First, in addition to improvements in self-reported health, older adults with access to the pension program experienced significant improvements in several important measures of health, including mobility, self-care, usual activities, and vision. Second, regarding the functional domains of mobility and self-care, we found that the females in the study group led in improvements over their male counterparts. Third, in our search for the mechanisms that drive positive retirement program results, we find evidence that changes in individual health behaviors, such as a reduction in drinking and smoking, and improved sleep habits, play an important role. Our findings point to the potential benefits of retirement programs resulting from social spillover effects. In addition, these programs may lessen the morbidity burden among the retired population.
Steam Reforming of Biomass Pyrolysis Oil: A Review
Authors: Adeniyi Adewale George , Otoikhian Kevin Shegun , Ighalo Joshua O. 
Published: April 2019

Abstract
The steam reforming of biomass pyrolysis oil is a well-established means of producing the more useful bio-hydrogen. Bio-oil has a comparatively low heating value, incomplete volatility and acidity, hence upgrading to a more useful product is required. Over the years, the experimental conditions of the process have been studied extensively in the domain of catalysis and process variable optimisation. Sorption enhancement is now being applied to the system to improve the purity of the hydrogen stream. Lifecycle analyses has revealed that bio-hydrogen offers considerable reductions in energy consumption compared to fossil fuel-derived hydrogen. Also, green-house-gas savings from the process can also be as high as 54.5 %. Unfortunately, techno-economic analyses have elucidated that bio-hydrogen production is still hampered by high production costs. Research endeavours in steam reforming of biomass bio-oil is done with an eye for developing added value products that can complement, substitute (and one day replace) fossil fuels whilst ameliorating the global warming menace.
Asymptotic orbital shadowing property for diffeomorphisms
Authors: Lee Manseob 
Published: April 2019

Abstract
Let M be a closed smooth Riemannian manifold and let f : M → M be a diffeomorphism. We show that if f has the C1 robustly asymptotic orbital shadowing property then it is an Anosov diffeomorphism. Moreover, for a C1 generic diffeomorphism f, if f has the asymptotic orbital shadowing property then it is a transitive Anosov diffeomorphism. In particular, we apply our results to volume-preserving diffeomorphisms.
Hopf bifurcation and the existence and stability of closed orbits in three-sector models of optimal endogenous growth
Authors: Nishimura Kazuo , Shigoka Tadashi 
Published: April 2019

Abstract
The present paper constructs a family of three-sector models of optimal endogenous growth, and conducts exact bifurcation analysis. In so doing, original six-dimensional equilibrium dynamics is decomposed into five-dimensional stationary autonomous dynamics and one-dimensional endogenously growing component. It is shown that the stationary dynamics thus decomposed undergoes supercritical Hopf bifurcation. It is inferred from the convex structure of our model that the dimension of a stable manifold of each closed orbit thus bifurcated in this five-dimensional dynamics should be two.
Bubble on real estate: the role of altruism and fiscal policy
Authors: Clain-Chamosset-Yvrard Lise , Seegmuller Thomas 
Published: April 2019

Abstract
In this paper, we are interested in the interplay between real estate bubble, aggregate capital accumulation and taxation in an overlapping generations economy with altruistic households. We consider a three-period overlapping generations model with three key elements: altruism, portfolio choice, and financial market imperfections. Households realise different investment decisions in terms of asset at different periods of life, face a binding borrowing constraint and leave bequests to their children. We show that altruism plays a key role on the existence of a productive real estate bubble, i.e. a bubble in real estate raising physical capital stock and aggregate output. The key mechanism relies on the fact that a real estate bubble raises income of retired households. Because of higher bequests, there children are able to invest more in productive capital. Introducing fiscal policy, we show that raising real estate taxation dampens capital accumulation.
Geodynamic Complexes and Structures of Transbaikalia: Record in Gravity Data
Authors: Dobretsov N.L. , Buslov M.M. , Vasilevsky A.N. 
Published: April 2019

Abstract
—The Transbaikalian region comprises several known geologic structures: the Mesozoic Mongolia-Okhotsk orogen, the Cenozoic Baikal rift system, and the world largest Angara–Vitim granitic batholith. They all formed upon heterogeneous Neoproterozoic– Early Paleozoic continental-margin complexes of the Siberian craton. The region is subject to the influence of mantle plumes, which induced Mesozoic–Cenozoic volcanism and controlled structural and lithological changes in the crust in the early history.
Transbaikalia, which has been a scene of multiple tectonic events, is a model area for geophysical (in particular, gravity) surveys for various geological and geodynamic applications. As a novel approach, we interpret geological and geodynamic data from the region with reference to the pattern of free-air and Bouguer gravity anomalies revealed by satellite altimetry. Bouguer anomalies highlight large structures in the lithospheric mantle which were produced in the Cenozoic mainly by the activity of mantle plumes. Basaltic lava fields were confirmed to be almost coeval with mantle anomalies and to record the presence of the plume head at the crustal base. However, the origin of the Late Paleozoic Angara–Vitim granitic batholith was only tentatively attributed to the plume activity, based on gravity data. Mesozoic metamorphic core complexes (MCC) and basins that formed during the evolution of the Mongolia–Okhotsk orogen show up clearly on the map of free-air anomalies. Most of the MCC revealed in Transbaikalia coincide with oval gravity highs and border negative elongate features corresponding to Mesozoic basins.
The zone of Cenozoic tectonism stands out in the pattern of free-air anomalies as maximum gravity contrasts, with the values changing from –110 to –120 mGal in basins to + 90 or +100 mGal in ranges. This zone encompasses rift basins filled with Cenozoic or, locally, Mesozoic sediments, which jointly form a domino-like system of rhomb-shaped structures typical of the Baikal rift system and, in general, of Cenozoic Central Asia resulted from the far-field effect of the India–Eurasia collision.