bluuebunny/crossref_metadata_2025_split huggingface dataset:
Onyx embolization with the Apollo detachable tip microcatheter: A single-center experience
Authors: Miller Timothy R , Giacon Luciano , Kole Matthew J , Chen Rong , Jindal Gaurav , Gandhi Dheeraj 
Published: February 2018

Purpose The Apollo Onyx Delivery Microcatheter (Ev3, Irvine, CA) is a detachable-tip microcatheter that was developed to reduce the risk of microcatheter entrapment during ethylene-vinyl alcohol copolymer (Onyx) embolizations. We report our experience with the microcatheter in a variety of neurointerventional procedures. Methods We retrospectively reviewed all Onyx embolizations performed in the head, neck, and spine using the Apollo Onyx Delivery Microcatheter from its introduction at our institution in July 2014 to August 2016. Information regarding patient diagnoses, procedural details, as well as clinical outcomes were obtained from the electronic medical record, procedure reports, and relevant angiographic imaging. Results A total of 58 arterial pedicle Onyx embolizations were performed in 37 patients. There were no cases of microcatheter entrapment, early/inadvertent tip detachment, or vessel injury upon removal of the device. There were two instances (3.5%) of leakage of Onyx from the microcatheter detachment site during embolization, which did not result in adverse sequelae. Clinical outcomes were excellent, with nearly all embolizations achieving the intended goal. In multivariate analysis, length of Onyx reflux along the microcatheter tip and utilization of a higher viscosity agent, Onyx 34, were significantly associated with tip detachment. Conclusion The use of the Apollo Microcatheter is both safe and effective during neurointerventional embolizations using Onyx. Leakage of liquid embolic agent from the detachment site is an infrequent technical complication that may be encountered with the device.
Minimal residual hairy cell leukemia eradication with moxetumomab pasudotox: phase 1 results and long-term follow-up
Authors: Kreitman Robert J. , Tallman Martin S. , Robak Tadeusz , Coutre Steven , Wilson Wyndham H. , Stetler-Stevenson Maryalice , FitzGerald David J. , Santiago Linda , Gao Guozhi , Lanasa Mark C. , Pastan Ira 
Published: February 2018

Key PointsMoxetumomab pasudotox eradicated HCL MRD in >50% of CRs, even by the most sensitive measure, bone marrow aspirate flow cytometry. Elimination of MRD was significantly associated with prolonged CR duration.
Economic evaluations and their use in infection prevention and control: a narrative review
Authors: Rennert-May Elissa , Conly John , Leal Jenine , Smith Stephanie , Manns Braden 
Published: February 2018

Abstract
Background
The objective of this review is to provide a comprehensive overview of the different types of economic evaluations that can be utilized by Infection Prevention and Control practitioners with a particular focus on the use of the quality adjusted life year, and its associated challenges. We also highlight existing economic evaluations published within Infection Prevention and Control, research gaps and future directions.

Design
Narrative Review.

Conclusions
To date the majority of economic evaluations within Infection Prevention and Control are considered partial economic evaluations. Acknowledging the challenges, which include variable utilities within infection prevention and control, a lack of randomized controlled trials, and difficulty in modelling infectious diseases in general, future economic evaluation studies should strive to be consistent with published guidelines for economic evaluations. This includes the use of quality adjusted life years. Further research is required to estimate utility scores of relevance within Infection Prevention and Control.
Should psychiatrists write fiction?
Authors: Bladon Henry 
Published: February 2018

SummaryThis paper looks at the relationship between fiction and psychiatry. Specifically, the idea of psychiatrists as fiction writers is explored, and reference is made to various fictional texts to illustrate the problems of stigma and negative imagery. These two main areas of focus are highlighted as ones that the practice of writing fiction might address, and some potential pitfalls are discussed. The paper suggests how psychiatrists might ameliorate the present problems by incorporating their unique clinical skills and knowledge into fictional narratives.Declaration of interestNone.
Artificial In Vitro Biosynthesis Systems for the Development of Pseudo-Natural Products
Authors: Goto Yuki , Suga Hiroaki 
Published: February 2018

Abstract
Recent advances in genome databases have allowed discovery of novel classes of natural products and their biosynthetic enzymes. Given the potentials and advantages of the biosynthetic enzymes, they are applicable to not only the production of natural products but also synthesis and discovery of artificial molecules with desired functions. This account describes our recent efforts to develop artificial in vitro biosynthesis systems that potentially allow for the elaboration of pseudo-natural peptides with novel bioactivities.
Valid but Invalid: Suboptimal ImPACT Baseline Performance in University Athletes
Authors: WALTON SAMUEL R. , BROSHEK DONNA K. , FREEMAN JASON R. , CULLUM C. MUNRO , RESCH JACOB E. 
Published: February 2018

ABSTRACT

Purpose
This study aimed to investigate the frequency of valid yet suboptimal Immediate Postconcussion Assessment and Cognitive Test (ImPACT) performance in university athletes and to explore the benefit of subsequent ImPACT administrations.

Methods
This descriptive laboratory study involved baseline administration of ImPACT to 769 university athletes per the institution’s concussion management protocol. Testing was proctored in groups of ≤2 participants. Participants who scored below the 16th percentile according to ImPACT normative data were readministered the ImPACT test up to two additional times because these scores were thought to be potentially indicative of suboptimal effort or poor understanding of instructions. Descriptive analyses were used to examine validity indicators and individual Verbal and Visual Memory, Visual Motor Speed, and Reaction Time ImPACT composite scores in initial and subsequent administrations.

Results
On the basis of ImPACT’s validity criteria, 1% (9/769) of administrations were invalid and 14.6% (112/769) had one or more composite score of <16th percentile but were considered valid. After one readministration, 71.4% (80/112) achieved scores of ≥16th percentile and an additional 18 of 32 scored ≥16th percentile after a third administration. Verbal Memory was most commonly <16th percentile on the first administration (43%), Verbal Memory and Visual Motor Speed on the second administration (44% each), and Visual Motor Speed alone on the third administration (50%).

Conclusions
Approximately 16% of ImPACT records were flagged as invalid or had one or more composite scores of <16th percentile, potentially indicative of suboptimal performance. Upon readministration, 88% of those participants scored >16th percentile. Clinicians must be aware of suboptimal ImPACT performance as it limits the clinical utility of the baseline assessment. Further research is needed to address factors leading to “valid” but invalid baseline performance.
Smoking and diabetes: An unhealthy relationship
Authors: Phillips Anne 
Published: February 2018

Smoking increases the risk of being diagnosed with diabetes, and once diagnosed, increases the risk of complications occurring. Anne Phillips provides an overview of the evidence Smoking is the biggest avoidable cause of death, disability, and social inequality in health in the UK. Smokers are at increased risk of developing type 2 diabetes, and the risk reduces when people stop smoking. In those with diabetes, smoking increases the risk of experiencing complications. Macrovascular complications, such as stroke and cardiovascular disease, are also more common in people who smoke. Smoking can also inhibit wound healing, affect tissue health and accelerate the occurrence of microvascular complications. Practice nurses have a duty to inform patients of these increased risks and have an opportunity to reduce harm by encouraging smoking cessation, whether by traditional stop smoking methods or e-cigarettes.
Why is pre-exposure rabies vaccination important?
Authors: Brewer Catherine 
Published: February 2018

Health professionals providing travel advice must understand the purpose of, and recommendations for, pre- and post-rabies exposure and communicate them to travellers, writes Catherine Brewer Rabies is an acute viral encephalomyelitis caused by members of the Lyssavirus genus. The rabies virus attacks the central nervous system, resulting in progressive inflammation of the spinal cord and brain ( National Travel Health Network and Centre, 2016 ). Once symptoms develop, rabies is almost always fatal; however, it is vaccine-preventable. Having a full understanding of the gravity of the disease, plus the purpose and regime of the pre- and post-exposure recommendations, and communicating these clearly, will allow travellers to make informed decisions. It is also vital that people know what to do if they have a potential exposure, and receive the correct post-exposure treatment, regardless of their vaccination status.
Early outcomes of patients transferred with ruptured suprarenal aneurysm or dissection
Authors: Rudarakanchana N , Hamady M , Harris S , Afify E , Gibbs RGJ , Bicknell CD , Jenkins MP 
Published: February 2018

Objective Despite centralisation of the provision of vascular care, not all areas in England and Wales are able to offer emergency treatment for patients with acute conditions affecting the aorta proximal to the renal arteries. While cardiothoracic centres have made network arrangements to coordinate care for the repair of type A dissections, a similar plan for vascular care is lacking. This study investigates early outcomes in patients with ruptured suprarenal aortic aneurysm or dissection (rSRAD) transferred to a specialist centre. Methods Retrospective observational study over a five-year period (2009–2014) assessing outcomes of patients with ruptured sRAD diagnosed at their local hospital and then transferred to a tertiary centre capable of offering such treatment. Results Fifty-two patients (median age 73 years, 32 male) with rSRAD were transferred and a further four died during transit. The mean distance of patient transfer was 35 miles (range 4–211 miles). One patient did not undergo intervention due to frailty and two died before reaching the operating theatre. A total of 23 patients underwent endovascular repair, 9 hybrid repair and 17 open surgery. Median follow-up was 12 months (range 1–43 months). Complications included paraplegia (n = 3), stroke (n = 2), type IA endoleak (n = 4); 30-day and in-hospital mortality were 16% and 27%. For patients discharged alive from hospital, one-year survival was 67%. Conclusions Although the number of patients with rSRAD is low and those who are transferred alive are a self-selecting group, this study suggests that transfer of such patients to a specialist vascular centre is associated with acceptable mortality rates following emergency complex aortic repair.
Book Reviews
Authors: Chowdhary Nimit , Dixit Saurabh Kumar , Koc Erdogan , Korstanje Maximiliano E. 
Published: February 2018

Abstract
Reinventing the Local in Tourism: Producing, Consuming and Negotiating Place, Antonio Paolo Russo and Greg Richards (2016) Bristol/ Buffalo, NY: Channel View Publications, xviii + 269 pp., ISBN: 9781845415686, p/bk, $59.99
The Routledge Handbook of Hospitality Studies, Conrad Lashley (ed.) (2017) Abingdon: Routledge, xv + 442 pp., ISBN: 9781138931121, h/bk, £150.00
Food and Drink Tourism: Principles and Practices, Sally Everett (2016) London: Sage, 464 pp., ISBN: 9781446267721, p/bk, £24.67
Mega Events as Economies of the Imagination: Creating atmospheres for Rio 2016 and Tokyo 2020, Rodanthi Tzanelli (2018) Abingdon: Routledge, 234 pp., ISBN: 9781138300286, h/bk, £105.00
Potential Effect of Pharmacotherapy on Sympathetic Arousal in Autism
Authors: Bujnakova I , Ondrejka I , Mestanik M , Fleskova D , Sekaninova N , Farsky I , Tonhajzerova I 
Published: February 2018

Abstract

Background: Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder associated with autonomic nervous system (ANS) abnormalities. Moreover, at least 50% of children with ASD suffer from other comorbid diseases such as anxiety, depression, and attention deficit hyperactivity disorder (ADHD) associated with receiving psychotropic medication. From this context we aimed to evaluate changes in sympathetic arousal using analysis of electrodermal activity (EDA) as an index of sympathetic cholinergic activity in treated and non-treated autistic children under resting conditions.

Methods: We examined 23 children with ASD and 14 healthy age- and gender-matched children at the age of 7–15 years. The ASD patients were divided into ASD non-treated group (n=12) and ASD treated group (n=11). The EDA was continuously monitored during resting phase in a supine position. The EDA amplitude (μS) was computed as an average of 5 min baseline period.

Results: We found significantly lower EDA in ASD non-treated subgroup compared to controls indicating subtle abnormalities in the regulation of the sympathetic nervous system. Although no significant differences were found between the ASD treated and non-treated subgroups the ASD treated group showed comparable sympathetic activity relative to controls indicating a potential ameliorated treatment effect on sympathetic arousal in ASD.

Conclusions: These findings could help to determine differences in sympathetic arousal in treated and non-treated children with ASD, which is important for assessment of autism-linked cardiovascular risk depending on pharmacotherapy.
On the generalized moment separability theorem for type 1 solvable Lie groups
Authors: Abdelmoula Lobna , Baklouti Ali , Bouaziz Yasmine 
Published: February 2018

Abstract
Let G be a type 1 connected and simply connected solvable Lie group.
The generalized moment map for π in

{\widehat{G}}

, the unitary dual of G, sends smooth vectors of the representation space of π to

{{\mathcal{U}(\mathfrak{g})}^{*}}

, the dual vector space of

{\mathcal{U}(\mathfrak{g})}

. The convex hull of the image of the generalized moment map for π is called its generalized moment set, denoted by

{J(\pi)}

. We say that

{\widehat{G}}

is generalized moment separable when the generalized moment sets differ for any pair of distinct irreducible unitary representations.
Our main result in this paper provides a second proof of the generalized moment separability theorem for G.
Stranger/Europe
Authors: Leerssen Joep 
Published: February 2018

AbstractDrawing on the working methods of imagology, this article surveys the way in which an implicit or tacit European self-image has taken shape over the centuries through contrast with two non-European Others: the New World and the Mediterranean. The article shows how these two others merge into a self-image of European alienation and moral perplexity following the devastations of the Second World War: the European cities have become kasbahs, Europe has become its own Other.
Taming the Stranger: Domestication vs Foreignization in Literary Translation
Authors: Ajtony Zsuzsanna 
Published: February 2018

AbstractThe translator’s task is to bridge the gap between the source text (ST) and the target text (TT), to mediate between the source culture (SC) and the target culture (TC). Cultural mediation is always more than linguistic mediation: it facilitates understanding between cultures. Cultural mediators need to be extremely aware of their own cultural identity, understanding how their own culture influences perception (ethnocentric attitude). While foreignization introduces the TT audience to the ST culture as much as possible, making the foreign visible, domestication brings two languages and two cultures closer, minimizing the foreignness of the TT, conforming to the TC values, and making the unfamiliar accessible (Venuti 1995, Munday 2016). This paper investigates different ways to find the balance between these two tendencies, offering examples from literary translation.
The Original Public Meaning of Amendment in the Origination Clause Versus the Patient Protection and Affordable Care Act
Authors: Smyth Daniel J. 
Published: February 2018

Abstract
Robert Natelson recently published his article, The Founders’ Origination Clause and Implications for the Affordable Care Act, in the Harvard Journal of Law & Public Policy. This article argued the original understanding of the scope of the Senate’s power to amend the House of Representatives’ bills for raising revenue in the Origination Clause permits complete substitutes that are new bills for raising revenue, such as the Patient Protection and Affordable Care Act (PPACA). The original understanding of a constitutional word or provision is what the ratifiers of the Constitution thought was the meaning of the word or provision. When the Senate originated PPACA as an amendment to the House’s Service Members Home Ownership Tax Act of 2009, the Senate replaced the entire House bill, except for the bill’s number, with PPACA.
I consider the original public meaning—not the original understanding—of a constitutional word or provision, unless unrecoverable, to be the controlling meaning of that word or provision. The original public meaning is the meaning that a “reasonable speaker of English” during the founding era would have ascribed to the word or provision. My article argues the original public meaning of amendment is clear and disallows complete substitutes. For instance, founding-era dictionaries indicate an amendment was a change or alteration to something that transformed the thing from bad to better. This definition suggests an amendment must not be a complete substitute because an amendment must preserve at least a part of the thing being amended so that there is something to transform from bad to better.
My article further argues the preponderance of evidence suggests the original understanding of the scope of an amendment actually disallows complete substitutes. For example, much evidence from the Philadelphia Convention, Confederation Congress, state legislatures, and state conventions suggests the dominant view among the founders was that an amendment to the Articles of Confederation, the legal compact between 13 states enacted in 1781, could not be a complete substitute.
My conclusion argues PPACA or any other such complete substitute violates the original public meaning of the scope of an amendment.
Analytical performance of an automated volumetric flow cytometer for quantitation of T, B and natural killer lymphocytes
Authors: Degandt Simon , Peeters Bart , Jughmans Stijn , Boeckx Nancy , Bossuyt Xavier 
Published: February 2018

Abstract

Background:
Quantitation of lymphocyte subsets (B cells, T cells, CD4 and CD8 T cells and NK cells) classically relies on quantitation of lymphocytes and immunophenotyping by flow cytometry. AQUIOS CL (Beckman Coulter) is a fully automated system that performs an onboard volumetric cell count, automatically processes the sample (staining, lysing and fixation) and analyzes the results. We compared AQUIOS CL to a dual-platform analysis and evaluated analytical performance.

Methods:
We evaluated precision, sample stability, inter-sample carryover, linearity and interpanel consistency. AQUIOS CL was compared to a dual-platform method (Sysmex XE-5000 and BD FACSCanto-II). A total of 113 patient samples were included: 45 from posttransplant patients, 44 from children and 24 random routine samples. The degree of automation was scored through the need of manual revisions triggered by AQUIOS CL run notifications and run flags.

Results:
Intrarun and interrun variability was <9.1% with dedicated control material and <32.1% with patient samples. Relative values of lymphocyte subsets could be determined up to 48 h after venipuncture when the sample was kept at room temperature. There was no carryover and good linearity. Interpanel consistency was 3.3% for relative values and 9.4% for absolute values. Method comparison showed good analytical correlation between AQUIOS CL and a dual-platform method. Thirty-five percent of the samples triggered a run notification. In 74% of these samples, the results could be accepted without intervention, so in 26% of all samples, an unnecessary notification was generated.

Conclusions:
AQUIOS CL allows for reliable fully automated immunophenotyping of lymphocyte subset quantitation. Gating algorithms could be further improved.
Toward a Pedagogy of Firstness
Authors: Campbell Cary 
Published: February 2018

AbstractThis paper examines how the Peircean category of Firstness can illuminate pre-cognitive and pre-interpretative aspects of learning. This study can be understood as part of a broader edusemiotic project currently gaining momentum (cf. Semetsky (ed.) 2010, 2017; Stables and Semetsky 2014; Olteanu 2015). I explore various iterations of Peirce’s thought, from his early Lowell Lectures (1866) to what Strand (2013) has called his “rhetorical turn” following the introduction of the concept ofsemiosisin 1883. My contention is that engagement in arts-based processes is educationally useful in inducing and cultivating reflection on those primary aspects of consciousness that are often neglected by formal educational programs. My aim here is to explore what stimulates engaged absorption and examine how this can be applied to form an “education of inquiry” informed by Peirce’s pragmatism, which places contemplation on this pre-interpretative realm of meaning in a central role. In conclusion, the paper will show how an understanding of Firstness is necessary for understanding Peirce’s aesthetics, and thus his ethics, which depends upon the “habits of feeling” emerging from Firstness. Thus, we can understand how the cultivation of a “pedagogy of Firstness” is foundationally an ethical educational program.
Preemptive NUDT15 genotyping: redefining the management of patients with thiopurine-induced toxicity
Authors: Shah Swarup A.V. , Paradkar Minal U. , Desai Devendra C. , Ashavaid Tester F. 
Published: February 2018

AbstractBackground:Thiopurine methyltransferase (TPMT) gene variants have achieved limited success in predicting the outcome of thiopurine therapy, which shows wide inter-individual variations. The literature indicates a strong association between theNUDT15gene variant and thiopurine-induced toxicity in Asian patients. The present study intends to explore the role of theNUDT15variant (C415T) in Indian patients on thiopurine therapy.Methods:NUDT15andTPMTgenotyping were performed using amplification-refractory mutation system-polymerase chain reaction (ARMS-PCR) and the restriction fragment length polymorphism (RFLP) technique.Results:Of 370 samples received forTPMTtesting, 206 samples were available forNUDT15genotyping. TheNUDT15risk allele frequency was 10.7%, with the frequency of wild, heterozygous and mutant genotypes being 80.6%, 17.5% and 1.9%, respectively.TPMTvariants were seen in 13 of 370 (3.5%) patients, whereas theNUDT15variant was seen in 40 of 206 (19.4%) patients. Thiopurine-induced toxicity information was available for 101 patients, among whom 10 developed leukopenia and all harbored theNUDT15variant (p<0.0001).NUDT15was clinically more relevant thanTPMTin terms of sensitivity and specificity, as well as with a statistically significant difference in thiopurine dose requirement for patients with theNUDT15variant.Conclusions:A preemptiveNUDT15genotyping approach can therefore help identify high-risk patients (NUDT15C415T positive) who could benefit from thiopurine dose reduction, thereby preventing fatal thiopurine-induced toxicity.