bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance
Authors: Chen Fei , Long Qilai , Fu Da , Zhu Dexiang , Ji Yan , Han Liu , Zhang Boyi , Xu Qixia , Liu Bingjie , Li Yan , Wu Shanshan , Yang Chen , Qian Min , Xu Jianmin , Liu Suling , Cao Liu , Chin Y. Eugene , Lam Eric W.-F. , Coppé Jean-Philippe , Sun Yu 
Published: October 2018

AbstractChemotherapy and radiation not only trigger cancer cell apoptosis but also damage stromal cells in the tumour microenvironment (TME), inducing a senescence-associated secretory phenotype (SASP) characterized by chronic secretion of diverse soluble factors. Here we report serine protease inhibitor Kazal type I (SPINK1), a SASP factor produced in human stromal cells after genotoxic treatment. DNA damage causes SPINK1 expression by engaging NF-κB and C/EBP, while paracrine SPINK1 promotes cancer cell aggressiveness particularly chemoresistance. Strikingly, SPINK1 reprograms the expression profile of cancer cells, causing prominent epithelial-endothelial transition (EET), a phenotypic switch mediated by EGFR signaling but hitherto rarely reported for a SASP factor. In vivo, SPINK1 is expressed in the stroma of solid tumours and is routinely detectable in peripheral blood of cancer patients after chemotherapy. Our study substantiates SPINK1 as both a targetable SASP factor and a novel noninvasive biomarker of therapeutically damaged TME for disease control and clinical surveillance.
Effect of Carbon Nanotube-Metal Hybrid Particle Exposure to Freshwater Algae Chlamydomonas reinhardtii
Authors: Intrchom Worawit , Thakkar Megha , Hamilton Raymond F. , Holian Andrij , Mitra Somenath 
Published: October 2018

AbstractWe demonstrate for the first time the toxicity of carbon nanotube (CNT) metal hybrids on freshwater algae. Carbon nanotube-silver (CNT-Ag) and platinum hybrids (CNT-Pt) were synthesized and exposed to Chlamydomonas reinhardtii (C. reinhardtii), and their toxicity was compared to the pure metal salts. Interactions between CNT-metal and algae were studied using electron microscopy and it was observed that while outer membrane of the algal cell was damaged as a result of Ag+ toxicity from pure Ag, the CNT-Ag only caused the distortion of the cell wall. It was also observed that the CNT-Ag particles could be internalized and enclosed in internal vesicles in the algal cells. Long-term exposure of the CNT-metals showed delay in algal growth. CNT-Ag at a concentration of 5.0 mg/L showed 90% growth inhibition and also showed a significant effect on photosynthetic yield with a 21% drop compared to the control. It was observed that pure silver was more toxic compared with CNT-Ag for both growth and photosynthesis in the 96-hour exposure. In general, CNT-Pt showed significantly less toxic effects on the algae than CNT-Ag. Based on this study, it is postulated that the CNT suppressed the release of Ag+ from CNT-Ag hybrids, thus reducing overall toxicity.
Vertically symmetric broadband lumped element CMOS directional coupler
Authors: Doan N.‐T. , Yoon S.‐W. 
Published: October 2018

A vertically symmetric lumped element directional coupler (VSLEDC) providing broadband characteristics is proposed. In simulations, the proposed VSLEDC showed a 43.8% broader bandwidth than a horizontally and vertically symmetric lumped element directional coupler under similar design conditions for the same insertion loss. The proposed coupler was implemented in a Global Foundry 130 nm CMOS technology. The overall chip size was 1300 µm × 850 µm. The coupling was designed to be −10 dB at 1 GHz. The S‐parameter measurements showed an absolute bandwidth and a fractional bandwidth of 141.1 MHz and 14.11%, respectively. Within the bandwidth, the insertion loss was 1.6‒1.8 dB.
Ultrasound-assisted catheter placement in CT-guided HDR brachytherapy for the local ablation of abdominal malignancies: Initial experience
Authors: Damm Robert , El-Sanosy Shahen , Omari Jazan , Damm Romy , Hass Peter , Pech Maciej , Powerski Maciej 
Published: October 2018

Purpose To evaluate the safety and feasibility of sonographically-assisted catheter placement in interstitial high-dose-rate brachytherapy of abdominal malignancies.
Materials and Methods In an initial cohort of 12 patients and 16 abdominal tumors (colorectal liver metastases n = 9; renal cell cancer n = 3; hepatocellular carcinoma n = 2; cholangiocellular carcinoma n = 2), initial puncture and catheter placement for CT-guided brachytherapy were performed under sonographic assistance when possible. The interventional procedure was prospectively recorded and in-patient data were collected. All data underwent descriptive statistics and comparative analysis by the Mann-Whitney test.
Results In 12 out of 16 lesions (diameter 1.5 – 12.9 cm), initial puncture was successfully achieved under ultrasound guidance without utilization of CT fluoroscopy, yielding a significantly shorter mean total fluoroscopy time (14.5 vs. 105.5 s; p = 0.006). In 8 lesions visibility was rated better in ultrasound than in CT fluoroscopy (p = 0.2). No major or minor complications occurred within 30 days after treatment.
Conclusion Ultrasound-assisted catheter placement during interstitial CT-guided brachytherapy of abdominal tumors could improve catheter positioning and reduce radiation exposure for medical staff.
Key points Ultrasound-assisted catheter placement in CT-guided brachytherapy is safe and feasible. Ultrasound puncture may improve catheter positioning. Reduced CT fluoroscopy time can significantly help to minimize radiation exposure for medical staff.
Citation Format
An Evaluation of the Association of Reproductive History and Multiple Births during Adolescence with Postmenopausal Osteoporosis
Authors: Kaya Aski , Doğan Ozan , Başbuğ Alper , Sönmez Cemil , Sungur Mehmet , Ataoğlu Safinaz 
Published: October 2018

Abstract
Introduction Osteoporosis is the most common metabolic bone disease characterized by low bone mass. Reproductive factors are known to affect bone mineral density (BMD). Calcium loss from maternal bone and decreased BMD have been observed especially during pregnancy and lactation, although this loss has been reported to recover within 6 – 12 months. There is no consensus on whether the effect of reproductive factors on the bone is positive or negative. The adolescent period is important for total bone mass, and total bone mass is significant in osteoporosis. The aim of this study was to investigate the effect of first gestational age, multiple births during adolescence, interpregnancy interval and reproductive history such as duration of breastfeeding on bone mineral density in postmenopausal women.
Materials and Methods BMD was measured in a total of 196 postmenopausal patients and in accordance with the results, analysis was made of three groups as normal, osteopenia and osteoporosis. Dual Energy X-Ray Absorptiometry (DEXA) was used to take the lumbar, femoral and total bone BMD measurements.
Results No statistically significant difference was determined between the groups in respect of total breastfeeding time (p = 0.596). It was detected that an increased interpregnancy interval decreased the risk of osteoporosis. In patients with osteoporosis, the mean interpregnancy interval was 1.4 ± 0.73 years, while it was longer in patients with osteopenia (1.92 ± 1.20) and normal BMD (2.45 ± 1.77) (p = 0.005). While no effect was determined of the first gestational age on BMD, in the univariate logistic regression analysis, multiple births in the adolescent period were seen to increase the risk of osteoporosis 6.833-fold (p = 0.001, OR = 6.833, 95% CI = 2.131 – 21.908; p = 0.001). The increase in the age of menopause was determined to decrease the risk of osteoporosis (OR = 0.911, 95% CI = 0.843 – 0.985; p = 0.019).
Conclusion Having frequent births throughout the whole reproductive age and having more than one child in adolescence has an adverse effect on postmenopausal bone mineral densities.
Pharmacological Properties of Geraniol – A Review
Authors: Lei Yu , Fu Peng , Jun Xie , Cheng Peng 
Published: October 2018

AbstractGeraniol is an acyclic isoprenoid monoterpene isolated from the essential oils of aromatic plants including Cinnamomum tenuipilum, Valeriana officinalis, and several other plants. The limited source of geraniol from plant isolation cannot fulfill the great demand from the flavor and fragrance industries, which require maximizing geraniol production through biotechnology processes. The diverse activities of geraniol suggested that geraniol could treat various diseases as a promising drug candidate. In order to evaluate the potential of geraniol applied in a clinical trial, this review aims at providing a comprehensive summary of the pharmacological effects of geraniol. The publications retrieved from PubMed, ScienceDirect, Springer, and Wiley databases were collected and summarized for the last 6 years. Then, the potential application of geraniol as a drug is discussed based on its pharmacological properties, including antitumor, anti-inflammatory, antioxidative, and antimicrobial activities, and hepatoprotective, cardioprotective, and neuroprotective effects. Hence, this review aims at providing evidence of the pharmacological activities of geraniol in the context of further development as a drug candidate in clinical application.
Safe Motherhood Initiative: Early Impact of Severe Hypertension in Pregnancy Bundle Implementation
Authors: Simpson Lynn , Rochelson Burton , Ananth Cande , Bernstein Peter , D'Alton Mary , Chazotte Cynthia , Lavery Jessica , Zielinski Kristin ,   for the Safe Motherhood Initiative Severe Hypertension in Pregnancy Work Group
Published: October 2018

Objective To describe the implementation and early results of the American College of Obstetricians and Gynecologists District II Safe Motherhood Initiative's Severe Hypertension in Pregnancy bundle on the timely treatment of severe hypertension in New York State obstetric hospitals.
Methods This is a retrospective comparative study of two time periods during voluntary implementation of the Severe Hypertension in Pregnancy bundle in New York State's obstetric hospitals. The main outcome measure was the administration of an appropriate antihypertensive agent within 1 hour of the second elevated value for all pregnant or postpartum patients with severe hypertension.
Results Of the 117 obstetric hospitals participating in the Safe Motherhood Initiative, 111 (94.9%) submitted data included in this analysis. During the study period, 80 of the 111 (72.0%) hospitals reported implementing the hypertension bundle. Overall, 2.4% of pregnant women were diagnosed with severe hypertension, and 60 to 65% of patients were treated within an hour of the second elevated value. Although not statistically significant, a greater numbers of patients were treated within an hour of the second elevated value in the second time period compared with the first in most obstetric hospitals (overall 64.8 vs. 60.8%; p = 0.33).
Conclusion There were increasing numbers of patients receiving timely treatment of severe hypertension during early implementation of a Severe Hypertension in Pregnancy bundle in New York State obstetric hospitals. However, bundle implementation requires significant financial and human resources and the long-term impact on maternal morbidity and mortality in our state remains uncertain.
Precis There was a tendency toward more timely treatment of severe hypertension following implementation of a Severe Hypertension in Pregnancy bundle in New York obstetric hospitals.
Facebook framed
Authors: Lev-On Azi 
Published: October 2018

Abstract
The study explores how Facebook was framed during the “tent protest” – the largest social protest in Israel’s history. Findings from of a content analysis of the local Israeli press indicate that Facebook was framed mainly as a political instrument assisting the protest, especially in the stages of recruitment, organization and dissemination of information to protesters. Alongside such positive framing, also evident, albeit less frequently, was negative framing that portrayed Facebook activities as incompatible with genuine political action, and portrayed the “Facebook generation” as lazy and spoiled.
Political myth as a legitimation strategy
Authors: Kranert Michael 
Published: October 2018

Abstract
Golden age myths as an answer to political crises are a recurrent phenomenon. This article demonstrates how the idea of a past golden age as the answer to a crisis of society was employed in the discourses of the Third Way: At the turn of the 20th century, the Social Democrats (SPD) in Germany and New Labour in Britain employed a golden age myth to define their politics. Analysing a corpus of texts from the Labour Party and the SPD between 1990 and 2005, this article demonstrates how global ideological trends are locally legitimized differently through the use of local political myths. The major contribution to the field of political discourse analysis lies in the discussion of mythopoesis as a legitimatory strategy, as well as in the analysis of the local adaptation of the golden age myth, which draws on Laclau’s discourse theory and its idea of empty signifiers.
Once upon a time
Authors: Pfeifer Hanna , Spencer Alexander 
Published: October 2018

Abstract
The article examines the romantic narratives told by the “Islamic State” in the propaganda online videos of foreign fighters. Employing a method of narrative analysis, based on insight from Literary Studies and Narratology, it holds that while narratives of jihad differ to “war on terror” narratives told in the West with regard to their content, narratives of jihad employ a very western romantic genre style. Focusing on the narrative elements of setting, characterisation and emplotment the article illustrates a romantic narrative of jihad which contains classical elements of a romantic story in which the everyday person is forced to become a hero in a legitimate struggle against an unjust order for the greater good and in aid of the down trodden. The article thereby aims to contribute to the debate on why such narratives of jihad have an appeal in certain parts of western society.
Studies of Bentonite Added Protein-Tannic Acid Multilayer Thin Films
Authors: Lau H H , Kiryukhin M V , Yakovlev N L , Ooi C P 
Published: October 2018

Abstract
Bentonite added in bovine serum albumin (BSA) increases the thickness of the multilayer film. BSA-TA multilayer thin films are built on silicon surface. The growths of the multilayer thin films are investigated by ellipsometry. The surface morphologies of the multilayer thin films are characterised with scanning electron microscopy (SEM). Both BSA-TA and BSA-Bentonite (BSAB)-TA layer-by-layer (LbL) assemblies exhibit linear growth behaviour. For all multilayer films studied here, a large amount of tannic acid molecules is eluted during washing, indicating weak binding and reversible adsorption on BSA surface. Oppositely, BSA absorb irreversibly on TA-terminated layer.
Design and modeling of a walking mechanism for the self-adapting pipeline robot
Authors: Yang Xiaocui , Bai Panfeng , Shen Xinmin , Li Zhizhong , Yin Qin 
Published: October 2018

Abstract
Self-adapting pipeline robot is widely used in many industrial fields and the walking mechanism is its critical part. According to the actual dimensional demand of a certain pipeline and the requirement of self-adapting pipeline robot, a walking mechanism is designed based on the double-cross structure and modelled through utilizing 3D modeling software. The walking mechanism can adjust its size to adapt to pipeline with different diameters. The workbench can be kept in the center of the pipeline by optimization of size of the double-cross structure. There are two driving wheels in the bottom and one driving wheel in the top to constitute three-point type, which can improve the stability and load capacity of the robot. The H-type driving wheel is adopted to improve stability and reliability of the contact between the wheel and the guide. Through optimizing parameters of the double-cross structure, the designed walking mechanism can meet the requirement of the pipeline with diameters from 480mm to 600mm. Furthermore, constructions of the walking mechanism are modelled by the Solidworks modeling software, which can verify the feasibility of the design. Design and modeling of the walking mechanism are propitious to give technical support to maintenance and repair of the pipeline.
Frontiers and Opportunities: Highlights of the 2nd Annual Conference of the Chinese Antibody Society
Authors: Zhang Hongyu , Deng Mi , Lin Peng , Liu Junjian , Liu Cheng , Strohl William R , Wang Shouye , Ho Mitchell 
Published: October 2018

ABSTRACT
The Chinese Antibody Society (CAS) convened the second annual conference in Cambridge, MA, USA on 29 April 2018. More than 600 members from around the world attended the meeting. Invited speakers discussed the latest advancements in therapeutic antibodies with an emphasis on the progress made in China. The meeting covered a vast variety of topics including the current status of therapeutic antibodies, the progress of immuno-oncology, and biosimilars in China. The conference presentations also included the development of several novel antibodies such as antibodies related to weight loss, T-cell receptor-mimicking antibodies that target intracellular antigens, and tumor-targeting antibodies that utilize both innate and adaptive immune pathways. At the meeting, the CAS announced the launch of its official journal—Antibody Therapeutics—in collaboration with Oxford University Press. The conference was concluded by a panel discussion on how to bring a therapeutic drug developed in China to the USA for clinical trials.
Statement of Significance The CAS convened the second annual conference in Cambridge, MA, USA on 29 April 2018. The meeting covered a variety of topics, including therapeutic antibodies being tested in clinical trials, new antibodies (e.g., programmed cell death protein 1/programmed death-ligand 1 inhibitors) being developed in China, and T-cell receptor-mimicking antibodies that target intracellular antigens.
Liver tumorigenesis is promoted by a high saturated fat diet specifically in male mice and is associated with hepatic expression of the proto-oncogene Agap2 and enrichment of the intestinal microbiome with Coprococcus
Authors: Pedersen Kim B , Pulliam Casey F , Patel Aarshvi , Del Piero Fabio , Watanabe Tatiane T N , Wankhade Umesh D , Shankar Kartik , Hicks Chindo , Ronis Martin J 
Published: October 2018

Abstract
Liver cancer results in a high degree of mortality, especially among men. As fatty liver disease is a risk factor for development of hepatocellular carcinoma, we investigated the role of dietary fat type in tumor promotion by high-fat diets in mice after initiation with the chemical carcinogen diethyl nitrosamine. Tumor incidence and multiplicity were significantly greater in males than those in females. In males, fat type had complex effects on tumorigenesis. Preneoplastic foci were most prevalent in mice fed a polyunsaturated fat diet enriched in docosahexaenoic acid, whereas carcinomas and large visible liver tumors were significantly greater in mice fed a saturated fat diet made with cocoa butter relative to mice fed mono- or polyunsaturated fats. Different mechanisms thus seemed involved in early and late tumor promotion. The hepatic transcriptome and gut microbiome were assessed for traits associated with tumorigenesis. Hepatic expression of more than 20% of all genes was affected by sex, whereas fat type affected fewer genes. In males, the saturated fat diet induced expression of the proto-oncogene Agap2 and affected the expression of several cytochrome P450 genes, and genes involved in lipid, bile acid and fatty acid metabolism. The gut microbiome had a higher level of genus Akkermansia and a lower level of Firmicutes in females than in males. Males fed saturated fat had an altered microbiome, including an enrichment of the genus Coprococcus. In conclusion, sex and the dietary fat type affect the gut microbiome, the hepatic transcriptome and ultimately hepatic tumor growth.
The role of accelerated dental development on the occurrence of aberrant dental traits that indicate malocclusion
Authors: Dhamo Brunilda , Nguee Amanda M , Ongkosuwito Edwin M , Jaddoe Vincent W V , Wolvius Eppo B , Kragt Lea 
Published: October 2018

Summary

Background
Timing of dental development might help orthodontists to optimize initiation of treatment and to prevent and intercept dental misalignment. This study examines the association between timing of dental development and aberrant dental traits such as crowding, impaction, and hypodontia.

Methods
This study was performed using 4446 ten-year-old children from a multiethnic birth cohort, the Generation R Study. Dental development was defined using the Demirjian method. Crowding, impaction, and hypodontia were ascertained from 2D and 3D pictures and radiographs. We built three series of logistic regression models to test the associations of dental age with crowding, impaction, and hypodontia. Similar models were built to investigate the associations of the developmental stages of each left mandibular tooth with crowding, impaction, and hypodontia.

Results
Inverse associations were found between every 1-year increase in dental age and the presence of crowding [odds ratio (OR) = 0.84, 95% confidence interval (CI): 0.79, 0.89], impaction of teeth (OR = 0.66, 95% CI: 0.52, 0.84), and hypodontia (OR = 0.52, 95% CI: 0.47, 0.56). Lower developmental stages of the second premolar were associated with the presence of crowding (OR = 0.90, 95% CI: 0.83, 0.98). Lower developmental stages of the second premolar (OR = 0.88, 95% CI: 0.79, 0.98), first molar (OR = 0.76, 95% CI: 0.65, 0.90), and the second molar (OR = 0.83, 95% CI: 0.73, 0.94) were associated with the presence of tooth impaction. Lower developmental stages of all mandibular teeth except the central incisor were associated with hypodontia (P < 0.05).

Conclusion
Accelerated dental development is associated with lower occurrence of crowding, impaction, and hypodontia.
Social Support and Preventive Healthcare Behaviors Among Couples in Later Life
Authors: Han Sae Hwang , Kim Kyungmin , Burr Jeffrey A 
Published: October 2018

Abstract

Background and Study Objectives
Intimate partners and close friends represent two major sources of social support that are central to one’s health and health behaviors in later life. The aim of this study was to examine dyadic linkages between perceived social support (from spouses and friends) and preventive healthcare behaviors among coupled-individuals.

Design and Methods
Prospective data from the Health and Retirement Study (2010, 2012) were used to analyze a sample of coupled-individuals (dyad N = 1,902). A series of multilevel logistic regression (actor–partner interdependence) models were estimated to evaluate whether perceived social support from spouses and friends was associated with the likelihood of using two common forms of preventive healthcare services (i.e., influenza vaccination and cancer screenings).

Results
Apart from the role of perceived support from spouse on flu vaccinations, wives’ preventive healthcare behaviors were unrelated to perceived social support. In contrast, husbands’ preventive healthcare behaviors showed consistent associations with perceived social support from friends for the 2-year observation period. Further, husbands’ receipt of prostate cancer screening was associated with wives’ perceptions of social support from spouse as well as friends.

Discussion and Implications
These findings contributed to our understanding of the health advantages associated with being in a marital relationship for preventive healthcare behaviors, especially for men. Future research should unpack the pathways through which social support of various forms is associated with obtaining needed preventive health services.