bluuebunny/crossref_metadata_2025_split huggingface dataset:
Major QTL controls adaptation to serpentine soils in Mimulus guttatus
Authors: Selby Jessica P. , Willis John H. 
Published: November 2018

AbstractSpatially varying selection is a critical driver of adaptive differentiation. Yet, there are few examples where the fitness effects of naturally segregating variants that contribute to local adaptation have been measured in the field. Plant adaptation to harsh soil habitats provides an ideal study system for investigating the genetic basis of local adaptation. The work presented here identifies a major locus underlying adaptation to serpentine soils in Mimulus guttatus and estimates the strength of selection on this locus in native field sites. Reciprocal transplant and common‐garden studies show that serpentine and nonserpentine populations of M. guttatus differ in their ability to survive on serpentine soils. We directly mapped these field survival differences by performing a bulk segregant analysis with F2 survivors from a field transplant study and identify a single QTL where individuals that are homozygous for the nonserpentine allele do not survive on serpentine soils. Genotyping the survivors from an independent mapping population reveals that this same QTL controls serpentine tolerance in a second, geographically distant population. Finally, we show that this QTL controls tolerance to soil properties, as opposed to some other aspect of the field sites that may differ, by performing a laboratory‐based common‐garden experiment in native serpentine soils that replicates the survival differences observed in the field. These results indicate that despite the myriad chemical and physical challenges plants face in serpentine habitats, adaptation to these soils in M. guttatus has a simple genetic basis.
Catch‐to‐stock dependence: The case of small pelagic fishery with bounded harvesting effort
Authors: Cruz‐Rivera Erica , Ramírez C. Héctor , Vasilieva Olga 
Published: November 2018

AbstractBiologic characteristics of schooling fish species explain why the rates of harvesting in pelagic fisheries are not proportional to the existent stock size and may exhibit no variation between the periods of fish abundance and scarcity. Therefore, the stock‐dependent nonlinearities in catchability must be reflected in the design of flexible fishing policies, which target the sustainable exploitation of this important natural resource. In this study, such nonlinearities are expressed through eventual variability of the “catch‐to‐stock” parameter that measures the sensitivity of an additional catch yield to marginal changes in the fish‐stock level. Using the optimal control modeling framework, we establish that each value of the “catch‐to‐stock” parameter generates a unique steady‐state size of the fish stock and the latter engenders an optimal fishing policy that can be sustained as long as the “catch‐to‐stock” parameter remains unchanged. We also prove the continuous dependence of the steady‐state stock and underlying fishing policy upon the mentioned “catch‐to‐stock” parameter and then focus on the analysis of the equilibrium responses to changes in this parameter induced by external perturbations.Recommendations for Resource ManagersMarginal catches of pelagic fish stocks do not react in a linear way to changes in existing stock level, and the latter is captured in our model by the “catch‐to‐stock” parameter. Each observable value ofengenders a unique steady‐state stock size that defines an optimal fishing policy, which can be sustained as long asremains unchanged.The ability of fishery managers to detect variations in the levels of hyperstability expressed by the “catch‐to‐stock” parametermay help them to anticipate new equilibrium responses in stock evolution and to make timely adjustments in the fishing policy.Plausible estimations of the “catch‐to‐stock” parameter, as well as detection of its possible alterations, can be carried out within the framework of Management Strategy Evaluation (MSE) approach where different data collected inside and outside the fishery are contrasted via the validation of a relatively simple decision‐making model (presented in this paper) coupled with other “operation models” of higher complexity.If the “catch‐to‐stock” parameter cannot be reasonably assessed (), the fishery managers may rely upon the lower bound of stationary stock size, which depends on economic and biological factors (such as the present and future economic values of the exploited fish stock, its marginal productivity, and underlying dynamics of biological growth).
Impacts of altered disturbance regimes on community structure and biodiversity mediated by fecundity–tolerance interactions
Authors: Miller Adam D. , Hsing Pen‐Yuan , Roxburgh Stephen H. , Fisher Charles R. , Shea Katriona 
Published: November 2018

AbstractWe present an investigation of the effects of disturbance and fecundity–tolerance strategies on community composition. We develop a theoretical model and apply it to macrofaunal communities at deep‐sea hydrothermal vents. We characterize community outcomes and find that dominance, coexistence, and alternative stable equilibria can all result from the interplay of disturbance regimes and fecundity–tolerance interactions. We show that fecundity–tolerance trade‐offs can permit coexistence under disturbance, but a strict fecundity–tolerance trade‐off is not required for coexistence to arise. We further describe how coexistence depends on habitat availability and disturbance regimes. Generally, our model elaborates on fecundity–tolerance strategies as a new axis of trait variation in coexistence theory. Natural disturbance regimes vary considerably across regions, and anthropogenic disturbance to vent communities will escalate with the advent of deep‐sea mineral extraction. We demonstrate how anthropogenic changes to disturbance regimes may impact species diversity, pushing communities over thresholds leading to local species extinction.Recommendations for Resource Managers

Conventional wisdom suggests that disturbance‐adapted communities will not be strongly affected by novel perturbations associated with resource extraction or other human activities.
We show that differing fecundity–tolerance strategies can mediate coexistence in disturbance‐prone deep‐sea environments, but that small changes to the disturbance regime can alter community composition and result in species extirpation.
Natural disturbance should not be used as a rationale for expected low impacts of anthropogenic disturbance, for example, mining activities in management of deep‐sea mineral extraction. Appropriate impact studies should be performed for all communities where disturbances, such as mining, are planned.
Neonatal anesthesia in low birth weight babies at Hospital Nacional Guido Valadares, Dili, Timor‐Leste
Authors: Grace Robert F. 
Published: November 2018

AbstractOver a 6‐month period, eight neonates weighing less than 3 kg were operated on at Hospital Nacional Guido Valadares, Dili, Timor‐Leste. Each was operated on for an abdominal condition. There is no postoperative neonatal ventilation, neonatal inotropes, fluid warmers, or parenteral nutrition available at Hospital Nacional Guido Valadares. Medical air and nitrous oxide are unavailable. Oxygen from cylinders is the only gas available in theaters and on the wards. Generally equipment is problematic and not designed for neonates. Five of these infants perished in hospital perioperatively, representing an in‐hospital mortality of 62%, another is presumed to have died following discharge, and two recovered well. This represents an estimated overall mortality rate of 75%. This is not surprising given the difficult circumstances in theater and the limited postoperative support services available. The resources and time deployed in operating on these small neonates is significant. As difficult as it may be surgical enthusiasm and the uncertainties surrounding prognostication should not displace practical and realistic assessment of the likely outcome of operating on very small babies in low resource facilities where perioperative support is limited. Future development in the Timor‐Leste healthcare sector will hopefully provide an environment where improvements in outcome can be achieved.
Hyponatremia and MAP‐kinase inhibitors in malignant melanoma: Frequency, pathophysiological aspects and clinical consequences
Authors: Assan Florence , Vilaine Eve , Wagner Sandra , Longvert Christine , Saiag Philippe , Seidowsky Alexandre , Bourgault‐Villada Isabelle , Massy Ziad A. 
Published: November 2018

AbstractThe incidence of malignant melanoma has increased over the past two decades. A combined BRAF/MEK inhibitor regimen has been shown to lead to prolonged survival and progression‐free survival in patients with metastatic BRAF V600‐mutant melanoma. Different nephrotoxic effects have been described, among them hyponatremia. The goal of the present narrative review was to understand the pathophysiological mechanisms driving hyponatremia when using selective BRAF inhibitors and/or MEK inhibitors in order to propose potential strategies to prevent or to treat this side effect. Several mechanisms of kidney injury have been suggested including changes in glomerular and tubular function. However, the precise mechanisms of hyponatremia remain unknown. Our hypothesis is that BRAF/MEK inhibitors lead to hyponatremia and water retention (so‐called dilution hyponatremia) by activating aquaporin 2 (AQP2) trafficking from its intracellular compartment to the luminal cell membrane, and by activating ENaC channel. Therefore, we recommend treating the hyponatremia related to BRAF/MEK inhibitors with restriction of fluid intake.
Variability in space and time: contrasting fruit distribution patterns in the deceptive orchid Orchis militaris
Authors: Henneresse T. , Kaiser A. , Wesselingh R. A. , Tyteca D. 
Published: November 2018

Abstract

In angiosperms, a decrease in fruit production towards the apex of individual inflorescences is usually observed. Orchids are thought to be primarily pollination‐limited species, and non‐uniform pollination could cause this decrease pattern in several species. Fruit production was investigated in relation to flower position and floral display size in Orchis militaris (Orchidaceae), a deceptive species.

Over 2 years, eight populations of O. militaris were studied and fruit position along the inflorescence was recorded. Generalised linear models were performed to examine the effect of population, year, flower position and floral display size on fruit production.

The dominant pattern was characterised by a higher fruit set in the middle part of the inflorescence (parabolic pattern). A non‐directional pattern of fruit production was also detected in some populations. Within a given population, patterns were generally consistent among years. In one of the two study years and in one of the eight populations specifically, the proximal‐to‐distal decrease in fruit production was dramatic in plants with a large floral display but weak or absent in small displays.

Our study demonstrates the intraspecific diversity of fruit distribution patterns in O. militaris. Non‐uniform pollination along the inflorescence is likely to be responsible for the parabolic pattern, while irregular visitation could explain the non‐directional pattern of fruit production. Pattern variation among years and between populations could arise from spatiotemporal variation in pollinator assemblages. Resource competition effects could explain the interaction effect between display size and flower position.
Antimicrobial peptides of fish: innocuous alternatives to antibiotics
Authors: Chaturvedi Preeti , Bhat Raja Aadil Hussain , Pande Amit 
Published: November 2018

AbstractAntimicrobial peptides (AMPs) are the key components of the innate immune system and perform the various biological function which offers immunocompetence and homeostasis to the living organisms. Owing to their multidimensional properties, they can find an important role in therapeutics for the treatment of emerging diseases in fishes. Several AMPs are reported in fishes, including defensins, cathelicidins, hepcidins, histone‐derived peptides and piscidins having board antimicrobial spectrum. Various factors are necessary for the induction of AMPs expression like pathogen‐associated molecular patterns and damage‐associated molecular pattern. Moreover, with beneficial effects, AMPs are coupled with rare concerns which should be considered before bringing them under the label of ‘harmless alternative to antibiotics’.
Insight into aquaculture's potential of marine annelid worms and ecological concerns: a review
Authors: Pombo Ana , Baptista Teresa , Granada Luana , Ferreira Susana M. F. , Gonçalves Sílvia C. , Anjos Catarina , Sá Erica , Chainho Paula , Cancela da Fonseca Luís , Fidalgo e Costa Pedro , Costa José L. 
Published: November 2018

AbstractPolychaetes are marine annelid worms that can contribute to aquaculture diversification. Its culture has been viable, and commercially attempted, but intensive production has progressed only in few countries around the world. In the countries with no production, marine polychaetes are imported or harvested. A strong and sustained research investment provided to a better understanding of the nutritional requirements and reproduction of some species. Recent studies showed new technical improvements, which can lead to an important progress in productivity and give a new impetus to the polychaete production. Some marine worm species were identified as good candidates for integrated multitrophic aquaculture. The development of cost‐effective aquaculture techniques for marine annelid worms is essential to ensure a balance between commercial interests and the preservation of ecosystems. The influence of polychaete aquaculture on the environment and vice versa raise important concerns related to ecological security and sustainability of this activity. This review focus on the main technical improvements and advances that have been made in areas as diverse as: aquaculture potential of polychaetes, reared species, main species used worldwide, and highlights biological and ecological concerns, important challenges and recommendations.
Influence of growth differentiation factor 9 and bone morphogenetic protein 15 on in vitro maturation of canine oocytes
Authors: Garcia Pablo , Aspee Karla , Ramirez Georges , Dettleff Phillip , Palomino Jaime , Peralta Oscar A. , Parraguez Víctor H. , De los Reyes Monica 
Published: November 2018

ContentsGrowth differentiation factor 9 (GDF‐9) and bone morphogenetic protein 15 (BMP‐15) have pivotal roles in oocyte development in many species, therefore the aim was to investigate these factors during in vitro maturation (IVM) of canine oocytes. Canine cumulus oocytes complexes (COCs) were cultured in six groups for 72 hr in a supplemented TCM199‐Hepes medium as (a) Control group; (b) GDF‐9 antibody (Ab); (c) BMP‐15 Ab; (d) recombinant human (rh) GDF‐9; (e) rh BMP‐15 or (f) rh BMP‐15 and GDF‐9. Data were evaluated by ANOVA. The Abs against GDF‐9 or BMP‐15 had a negative impact on meiotic development. Higher (p < 0.05) number of oocytes was arrested at GVBD stage when they were incubated with either GDF‐9 Ab (64.4 ± 2.1%) or BMP‐15 Ab (67.2%± 4.9%) in comparison to those in control group (32.4 ± 7.8%). In contrast, more (p < 0.05) oocytes in control group reached MI (37.4 ± 1.3%) and MII stages (10.2 ± 2.1%) comparing to those groups with GDF‐9 Ab (23.1 ± 4.7% MI; 0.0% MII) or BMP‐15 Ab (16.4 ± 2.4%MI; 5.9% ± 2.1 MII). Higher rates (p < 0.05) of oocytes in control group stayed still arrested at GV (19.9 ± 8.6%) in comparison to those cultured with either rhGDF‐9 (3.7 ± 0.4%) or rhBMP‐15 (10.9 ± 0.7%). However, there were no differences in MII rates between oocytes cultured with GDF‐9 (14.7 ± 3.1) and BMP‐15 (7.8 ± 2.5) separately. But, more oocytes (p < 0.05) reached the MII stage (20.5 ± 3.8%) compared to those exposed to each protein separately and to the control group. These results suggest that these proteins likely contribute to the meiotic development in dogs.
Neural adaptations after 4 years vs 12 weeks of resistance training vs untrained
Authors: Balshaw Thomas G. , Massey Garry J. , Maden‐Wilkinson Thomas M. , Lanza Marcel B. , Folland Jonathan P. 
Published: November 2018

The purpose of this study was to compare the effect of resistance training (RT) duration, including years of exposure, on agonist and antagonist neuromuscular activation throughout the knee extension voluntary torque range. Fifty‐seven healthy men (untrained [UNT] n = 29, short‐term RT [12WK] n = 14, and long‐term RT [4YR] n = 14) performed maximum and sub‐maximum (20%‐80% maximum voluntary torque [MVT]) unilateral isometric knee extension contractions with torque, agonist and antagonist surface EMG recorded. Agonist EMG, including at MVT, was corrected for the confounding effects of adiposity (ie, muscle‐electrode distance; measured with ultrasonography). Quadriceps maximum anatomical cross‐sectional area (QACSAMAX; via MRI) was also assessed. MVT was distinct for all three groups (4YR +60/+39% vs UNT/12WK; 12WK +15% vs UNT; 0.001 < P ≤ 0.021), and QACSAMAX was greater for 4YR (+50/+42% vs UNT/12WK; [both] P < 0.001). Agonist EMG at MVT was +44/+33% greater for 4YR /12WK ([both] P < 0.001) vs. UNT, but did not differ between RT groups. The torque‐agonist EMG relationship of 4YR displayed a right/down shift with lower agonist EMG at the highest common torque (196 Nm) compared to 12WK and UNT (0.005 ≤ P ≤ 0.013; Effect size [ES] 0.90 ≤ ES ≤ 1.28). The torque‐antagonist EMG relationship displayed a lower slope with increasing RT duration (4YR < 12WK < UNT; 0.001 < P ≤ 0.094; 0.56 ≤ ES ≤ 1.31), and antagonist EMG at the highest common torque was also lower for 4YR than UNT (−69%; P < 0.001; ES = 1.18). In conclusion, 4YR and 12WK had similar agonist activation at MVT and this adaptation may be maximized during early months of RT. In contrast, inter‐muscular coordination, specifically antagonist coactivation was progressively lower, and likely continues to adapt, with prolonged RT.
Retrograde and oscillatory shear rate in young anabolic androgenic steroid users
Authors: de Souza Francis Ribeiro , Sales Allan Robson Kluser , Dos Santos Marcelo Rodrigues , Porello Rafael Armani , Fonseca Guilherme Wesley Peixoto da , Sayegh Ana Luiza Carrari , Filho Antonio Carlos Battaglia , Pereira Rosa Maria Rodrigues , Takayama Liliam , Oliveira Tiago Franco de , Yonamine Mauricio , Negrão Carlos Eduardo , Alves Maria Janieire de Nazaré Nunes 
Published: November 2018

Disturbed shear rate (SR), characterized by increased retrograde and oscillatory SR in the brachial artery, is associated with inflammation, atherosclerosis, endothelial dysfunction, and sympathetic hyperactivity. Young subjects do not have disturbed SR; however, elderly subjects do, which seems to be associated with sympathetic hyperactivity. Anabolic androgenic steroids (AAS) abuse in young is associated with increased muscle sympathetic nerve activity (MSNA). We hypothesized that AAS users might have disturbed SR. We tested the association between retrograde and oscillatory SR with MSNA. In addition, we measured the high‐sensitivity C‐reactive protein (hs‐CRP). We evaluated 10 male AAS users, age 27 ± 4 years, and 10 age‐matched AAS nonusers, age 29 ± 5 years. At rest, retrograde and oscillatory SR were evaluated by Doppler ultrasound, MSNA was measured with microneurography, and hs‐CRP was measured in blood sample. Flow‐mediated dilation (FMD) was also assessed. AAS users had higher retrograde SR (24.42 ± 17.25 vs 9.15 ± 6.62 s−1, P = 0.01), oscillatory SR (0.22 ± 0.13 vs 0.09 ± 0.07 au P = 0.01), and MSNA (42 ± 9 vs 32 ± 4 bursts/100 heart beats, P = 0.018) than nonusers. MSNA (bursts/100 heart beats) was correlated with retrograde SR (r = 0.50, P = 0.050) and oscillatory SR (r = 0.51, P = 0.042). AAS users had higher hs‐CRP [1.17 (0.44‐3.63) vs 0.29 (0.17‐0.70) mg/L, P = 0.015] and decreased FMD (6.42 ± 2.07 vs 8.28% ± 1.53%, P = 0.035) than nonusers. In conclusion, AAS abuse is associated with retrograde and oscillatory SR which were associated with augmented sympathetic outflow. In addition, AAS seems to lead to inflammation characterized by increased hs‐CRP. These alterations may have the potential of increasing the early risk of atherosclerotic disease in young AAS users.
The globalisation–welfare state nexus: Evidence from Asia
Authors: Potrafke Niklas 
Published: November 2018

AbstractHow globalisation influences social expenditure has been examined for industrialised countries. Globalisation has often been shown to be positively associated with social expenditure in established industrialised countries, a finding that corroborates the compensation hypothesis. Scholars have focused on industrialised countries, because social expenditure is difficult to measure in developing countries. I use new data on social expenditure for Asian non‐OECD countries. Globalisation is measured by the new KOF Globalisation Index. My results do not suggest that globalisation influenced social expenditures in Asia. Neither do the results suggest that the nexus between globalisation and social expenditures varied across high‐income countries, such as Hong Kong and Singapore, and lower‐income Asian countries or across Asian regions. It is conceivable that Asian citizens did not demand increasing social support when globalisation proceeded rapidly because they enjoyed family and other private assistance. Asian countries also have weaker tax and labour market institutions than OECD countries and have therefore more difficulties in increasing social expenditure.
A Method of Motion-Based Immersive Design System for Vehicle Occupant Package
Authors: Wan Jian , Wang Nanxin 
Published: November 2018

Assessing user experience on a new vehicle design objectively is critical for an automotive company to improve customer satisfactory of its products. The technology of motion capture and digital human modeling has been utilized in many recent studies to assist in the design process of a new product. Motions of human interacting with a new product are captured or simulated. The human body trajectory and swept volumes of the motion are overlaid with the product geometry in CAD, providing a guidance for the direction of new design changes. However, a CAD system generally requires some training to be efficiently used to review a design. A more intuitive and easier approach is preferred.
In recent years, Virtual and Augmented Reality (VR/AR) are taking root in engineering area. The technology provide great advantages to the applications of design review, process simulation, maintenance, and training, etc., by expanding the physical world with virtual components or helpful information.
This paper presents a new method of motion-based immersive design system for vehicle occupant package that integrates the technologies of VR/AR and digital human modeling. The method incorporates human motions captured or simulated along with the new geometry of a vehicle compartment inside a VR/AR environment. Through this, the designer is able to not only immersively experience the new design, but also observe the behavior of different users interacting with the design in the 3D environment. It provides a systematic and intuitive approach for a designer to quickly iterate through the test-review-revise design cycle and achieve a more accommodating and occupant friendly vehicle compartment design.