bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional divergence of TPX2 family members in Arabidopsis thaliana
Authors: Tomastikova Eva Dvorak , Rutten Twan , Dvorak Petr , Tugai Alisa , Ptosková Klara , Petrovska Beata , Damme Daniel van , Houben Andreas , Dolezel Jaroslav , Demidov Dmitri 
Published: July 2019

Abstract
Background

TPX2 (Targeting protein for Xklp2) is an evolutionary conserved microtubule-associated protein important for microtubule nucleation and proper mitotic spindle assembly. The protein was also described as an activator of the mitotic kinase Aurora A in humans and the Arabidopsis AURORA 1 (AUR1) kinase. In contrast to animal genomes that encode only one TPX2 gene in their genome, higher plants genomes encode a family with several TPX2-LIKE gene members (TPXL).

Results

Arabidopsis genome comprise of 21 TPXL genes. To better understand the functional divergence within the TPXL gene family in plants, we characterized eight genes most closely related to the canonical TPX2 Arabidopsis. TPXL genes of Arabidopsis can be divided into two groups. Group A proteins (TPXL2, 3, 4 and 8) contain Aurora binding and TPX2_importin domains, while group B proteins (TPXL1, 5, 6 and 7) harbor an Xklp2 domain. Canonical Arabidopsis TPX2 contains all above mentioned domains. We confirmed using in vitro kinase assays that the group A proteins contain a functional Aurora kinase binding domain and are able to at least double the activity of recombinant AUR1 kinase. Transient expression of GFP-tagged Arabidopsis TPX2-like proteins in Nicotiana benthamiana revealed preferential localization to microtubules and nuclei, except TPXL7, which localized mainly to the nuclear envelope. Co-expression of AUR1 together with TPX2-like proteins changed the localization of AUR1, indicating that these proteins serve as targeting factors for Aurora kinases.

Conclusion

Taken together, we visualize the various localizations of the TPX2-LIKE family in Arabidopsis as proxy to their functional divergence and provide evidence of their role in the targeted regulation of AUR1 kinase activity.
Transcriptome profiling analysis of sex-based differentially expressed mRNAs and lncRNAs in the brains of mature zebrafish (Danio rerio)
Authors: Yuan Wenliang , Jiang Shouwen , Sun Dan , Wu Zhichao , Wei Cai , Dai Chaoxu , Jiang Linhua , PENG SIHUA 
Published: July 2019

Abstract
Background: Similar to humans, the zebrafish brain plays a central role in regulating sexual reproduction, maturation and sexual behavior. However, systematic studies of the dimorphic patterns of gene expression in the brain of male and female zebrafish are lacking.
Results: In this study, the mRNA and lncRNAs expression profiles were obtained from the brain tissue samples of the three male and three female zebrafish by high-throughput transcriptome sequencing. We identified a total of 108 mRNAs and 50 lncRNAs with sex-based differential expression. We randomly selected four differentially expressed genes for RT-qPCR verification and the results certified that the expression pattern showed a similar trend between RNA-seq and RT-qPCR results. Protein-protein interaction network analysis, Gene Ontology (GO) analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed to obtain the biological significance of differentially expressed mRNA in the brain dimorphism of zebrafish. Finally, a Pearson correlation analysis was performed to construct the co-expression network of the mRNAs and lncRNAs.
Conclusions: We found that 12 new lncRNAs not only have significant gender specificity in the brain of zebrafish, and this finding may provide a clue to further study of the functional difference between male and female zebrafish brain.
Patient-physician communication about financial problems: A cross-sectional study among over-indebted individuals
Authors: Warth Jacqueline , Puth Marie-Therese , Zier Ulrike , Beckmann Niklas , Porz Johannes , Tillmann Judith , Weckbecker Klaus , Bosma Hans , Weltermann Birgitta , Münster Eva 
Published: July 2019

Abstract
Background

About every tenth household across Europe is unable to meet payment obligations and living expenses on an ongoing basis and is thus considered over-indebted. Previous research suggests that over-indebtedness reflects a potential cause and consequence of psychosomatic health problems and limited access to health care. However, it is unclear whether those affected discuss their financial problems with general practitioners that often serve as patients’ initial medical contact. Therefore, this study examined patient-physician communication about financial problems in general practice among over-indebted individuals.

Methods

We conducted a cross-sectional survey among clients of 70 debt advice agencies in North Rhine-Westphalia, Germany, in 2017. We assessed the prevalence of patient-physician communication about financial problems and its association with patient characteristics using descriptive statistics and logistic regression analysis. Of 699 individuals who returned the questionnaire (response rate: 50.2%), we included 598 respondents enrolled in statutory health insurance with complete outcome data in the analyses.

Results

Less than one fourth of respondents had ever discussed financial problems with their general practitioner (n=135; 22.6%). Individuals with a high educational level were less likely to communicate about financial problems compared to those with medium educational level (aOR 0.11; 95% CI 0.01-0.83) after adjustment for other sociodemographic characteristics, health status and measures of financial distress. Those without a migrant background (aOR 2.09; 95% CI 1.32-3.32), the chronically ill (aOR 1.90; 95% CI 1.16-3.13) and individuals who reported high financial distress (aOR 2.15; 95% CI 1.22-3.78) and cutting on necessities to pay for medications (aOR 1.86; 95% CI 1.12-3.09) were more likely to report communication than their counterparts after adjustment.

Conclusions

Few over-indebted individuals discussed financial problems with their general practitioner. The findings suggest that patients’ health status, coping strategies and perception of financial distress might contribute to variations in disclosure of financial problems. Thus, enhancing communication and screening by routine assessment of financial problems in clinical practice can help to identify vulnerable patients and promote access to health care and social services and well-being for all.
Working Memory and Decision making in children with ADHD: an analysis of delay discounting with the use of the dual-task paradigm
Authors: Fabio Rosa Angela , Bianco Marilla , Caprì Tindara , Marino Flavia , Ruta Liliana , Vagni David , Pioggia Giovanni 
Published: July 2019

Abstract
Objective

Deficits in working memory tasks have been widely documented in Attention Deficit Hyperactivity Disorder (ADHD) studies. The aim of this study is to evaluate the effects of working memory load in impulsivity during decision-making processes. A delayed discounting (DD) paradigm was used, comparing children with ADHD and age matched controls.

Method

Thirty-two children equally divided with typical development or ADHD between 8 and 10 years of age were assigned to sessions of a dual-task paradigm. The first task was a forced dual choice between different amount of moneys at different time delay, while the second task was the repetition of a random series of digits with different lengths.

Results

Compared to peers with typical development, delayed discounting was significantly stronger in children with ADHD and for heavier memory load conditions. Furthermore, the memory load impact was stronger in children with ADHD compared to children with typical development.

Discussion

Results are discussed in terms of the relation between working memory load and decision-making processes.
A cross-sectional study on caregivers’ perspective of the quality of life and adherence of paediatric HIV patients to highly active antiretroviral therapy
Authors: Lahai Michael , James Peter B. , Wannang Noel N. , Wurie Haja R. , Conteh Sorie , Bah Abdulai J. , Samai Mohamed H 
Published: July 2019

Abstract
Background

Non-compliance to highly active antiretroviral therapy (HAART) can lead to sub-therapeutic drug concentrations in children leading to emergence of drug resistance and poor quality of life in children with HIV/AIDS. This study assess the response of caregivers for determination of the percentage adherence, child and caregivers’ demographics and related characters to the four domains of quality of life in children (aged 14 years and under) on HAART.

Methods

A cross-sectional survey was done for 188 paediatric patients accompanied by their caregivers’ attending Ola During Children’s Hospital and Makeni Government Hospital between September and November 2016 in Sierra Leone with ethical approval obtained from the Sierra Leone Ethics and Scientific Review Committee; Directorate of Policy and Planning, Ministry of Health and Sanitation. Adherence to HAART was measured as no indication of a missed dose in the past week or month using three adherence questions on dose in the past week or month. Quality of life was assessed using the four domains of the Quality of life summary questionnaire (WHOQOL-BREF) as the dependent variable and the demographic characteristics of caregiver and child as the independent variable. Inferential test was used to determine the association between variables and the regression model to determine association of significant variables to the four domains of the WHOQOL BREF.

Results

The study showed 5.9% adherence among 188 paediatric HIV/AIDs patients. Caregiver HIV status and caregiver type were also found to be associated with quality of life domains with high mean values for HIV positive caregivers and caregiver type that included a member of the nuclear family (father, mother or siblings).

Conclusion

This study showed strong association for involvement of caregiver that includes the nuclear family, caregiver’s knowledge of their HIV status and adherence to HAART. Therefore, these factors can improve the quality of life of paediatric HIV/AIDS patients on highly active antiretroviral therapy.
Climate-smart water technologies for sustainable agriculture: a review
Authors: Patle G. T. , Kumar Mukesh , Khanna Manoj 
Published: July 2019

AbstractWorldwide water management in irrigated and rain-fed agriculture is becoming more and more complex to overcome the expected water scarcity stress. In addition to this, challenges of global warming and climate change would have to be met through the judicious application of water in agriculture through climate-smart water technologies. Agriculture is an important sector in India and many developing countries, providing huge employment opportunities to rural populations, and supporting them to achieve food and nutritional security goals. In this paper, an attempt has been made to address challenges of increasing food production and improving rural livelihoods, while safeguarding critical water resources for sustainable use through adaptive measures for effective water management, particularly in drought-prone regions. An integrated approach needs to be implemented in agricultural water management through adoption of innovations such as water harvesting, micro-irrigation and resource conservation farming to increase water-use efficiency in agriculture and other critical services to humans and animals. The aim of this study is to facilitate an improved understanding of the potential implications of climate change and adaptation options for agricultural water management and thereby assist policymakers in taking up adaptation challenges and developing measures to reduce the vulnerability of the farming sector to climate change.
Prediction of effluent quality in ICEAS-sequential batch reactor using feedforward artificial neural network
Authors: Khatri Narendra , Khatri Kamal Kishore , Sharma Abhishek 
Published: July 2019

Abstract
It is highly essential that municipal wastewater is treated before its discharge and reuse in order to meet the standard requirements for safe marine life and for farming and industries. It is beneficial to use reclaimed water, since availability of fresh water is inadequate. An investigation was conducted on the Jamnagar Municipal Corporation Sewage Treatment Plant (JMC-STP) to develop a feedforward artificial neural network (FF-ANN) model. It is an alternate for the modelling/ prediction of JMC-STP to circumvent over the versatile physical, chemical, and biological treatment process simulations. The models were developed to predict effluent quality parameters through influent characteristics. The parameters are pH, biochemical oxygen demand (BOD), chemical oxygen demand (COD), total suspended solids (TSS), total Kjeldahl nitrogen (TKN), ammonium nitrogen (AN) and total phosphorus (TP). The correlation coefficient RTRAINING and RALL were calculated for all parametric models. The MAD (mean absolute deviation), MSE (mean square error), RMSE (root mean square error) and MAPE (mean absolute percentage error) were evaluated for FF-ANN models. This proves to be a useful tool for the plant management to optimize the treatment quality as it enhances the performance and reliability of the plant. The simulation results were validated through the measured values.
BUSINESS ANALYSIS AND DESIGNING MODELS OF GOVERNANCE AND ALSO RISK MANAGEMENT FOR FINTECH AS EFFORTS OF FINANCING OPTIMIZATION IN MSMEs
Authors: Wulandari Putu Prima , Wijayanti Anita , Fitriasari Rizka 
Published: July 2019

The development of financial services based on technology or Financial Technology (Fintech) potentially gives a great contribution for Indonesiaâ€™s economy. Fintech is able to draw both investor and MSMEs business administrator together that need credit loans with easier requirements compare to conventional financial institutions. The purpose of this research is to find out the readiness of MSMEs for the service offered by Fintech related to financing activity, to find out the role of fintech towards MSMEs development and national financial system, and also to find out which governance and risk management model that suits Fintechâ€™s business field. Qualitative descriptive research method is used in this research with semi structured documentation and interview data collection technique to collect primary and secondary data. Data analysis technique used in this research is content analysis from various sources, including text source, survey result and interview result. The research result shows that the majority of MSMEs doers, about 81,8% of total respondents are absolutely ready in utilizing Fintech service. However, in this case, regulator needs to consider socializing the use of fintech in transaction process towards MSMEs to optimize the role of fintech as alternate financial source for MSMEs. The research result shows that model design of fintech governance and risk management in this research should adopt IT governance framework that includes strategic alignment, trust value delivery, resource management, business & IT risk management and performance management. Besides that, big data management alsoÂ becomes part of fintech business governance and risk management model design.Â
Tailoring of a Smartphone Smoking Cessation App (Kick.it) for Serious Mental Illness Populations: Qualitative Study
Authors: Klein Pauline , Lawn Sharon , Tsourtos George , van Agteren Joep 
Published: July 2019

Background
Smoking rates of Australians with severe mental illness (SMI) are disproportionately higher than the general population. Despite the rapid growth in mobile health (mHealth) apps, limited evidence exists to inform their design for SMI populations.

Objective
This study aimed to explore the feasibility, acceptability, and utility of adapting a novel smoking cessation app (Kick.it) to assist smokers with SMI to prevent smoking relapse and quit.

Methods
Using co-design, two in-depth interviews with 12 adult smokers and ex-smokers with SMI were conducted in this qualitative study. Stage 1 interviews explored participants’ smoking-related experiences and perceptions of social support for smoking cessation, informed the development of the stage 2 interview schedule, and provided context for participants’ responses to the second interview. Stage 2 interviews explored participants’ perceptions of the feasibility, utility, and acceptability of the app features for SMI populations.

Results
People with SMI perceived mHealth interventions to support their quit smoking attempts as feasible, acceptable, and useful. Key emerging themes included personalization of the app to users’ psychosocial needs, a caring app to mediate self-esteem and self-efficacy, an app that normalizes smoking relapse and multiple quit attempts, a strong focus on user experience to improve usability, and a social network to enhance social support for smoking cessation.

Conclusions
This study gained an in-depth understanding of the lived experiences of smoking and quitting among people with SMI and their perception of the Kick.it app features to help inform the tailoring of the app. Specific program tailoring is required to assist them in navigating the complex interactions between mental illness and smoking in relation to their psychosocial well-being and capacity to quit. This study describes the adaptations required for the Kick.it app to meet the specific needs and preferences of people with SMI. Results of this study will guide the tailoring of the Kick.it app for SMI populations. The study findings can also inform a co-design process for the future development and design of smoking cessation apps for SMI populations.
Neurohumoral Pathway in Heart Failure
Authors: Anggrahini Dyah Wulan 
Published: July 2019

Heart Failure is now considered as one of the leading cause for mortality and morbidity. It is affecting several organs and cause organ damages due to the myocardial failure to pump inadequate oxygenated blood to the body including metabolites, to end organs and peripheral tissues. Heart failure results from multifactorial mechanism including neurohumoral activations including increased activity of the sympathetic nervous system, renin-angiotensin aldosteron system, vasopression and the atrial natriuretic peptide. This neurohumoral pathway has significant contribution to the development of myocardial dysfunction that lead to clinical manifestation of heart failure. Some of the markers in these pathways have now been considered as an independent predictors of prognosis in heart failure patient.
Effect of organic fertilizers on nutrients content and essential oil composition of savory (Satureja hortensis L.)
Authors: Esmaielpour Behrooz , Rahmanian Mahdi , Khorramdel Surur , Foroghian Setareh 
Published: July 2019

abstractApplication of organic fertilizers in the production of these plants to eliminate or substantially reduce the use of chemical inputs and improve the growth and quality of plants. For instance, in present study the effect of vermicompost and spent mushroom compost application on nutritional status and essential oil components of summer Savory (Satureja hortensis L.) was investigated.This experiment was conducted in research greenhouse of Faculty of Agriculture at Mohaghegh Ardabili University in layout of completely randomized design with five replications on Savory in 2014. Experimental treatments included different substrates contain vermicompost, washed and unwashed spent mushroom compost in five levels (10, 20, 30, 40 and 50 Percent v/v). After flowering, plants were harvested and parameters such as leaf area, leaf and plant dry weight, chlorophyll index of leaf and N, P, K, and Ca content and essential oil component of plants were measured.The results showed that the effect of organic substrates on macronutrient content and growth parameters of savory were significant. The highest Nitrogen content (6.3%) and Phosphorus (0.98%) in shoot of savory was obtained in substrate supplemented with 40% vermicompost. Plants grown in the media containing 30% of vermicompost and 50% washed spent mushroom compost (SMC) have higher potassium (3.19%) and calcium (2.48%) content, respectively. The lowest nitrogen, phosphorus and potassium content in the aerial part was obtained in the control treatment. Moreover, application of organic fertilizers significantly affected on essential oil percent and composition compounds of savory. The highest and lowest essential oil content were obtained in plants in substrates containing 30 % of vermicompost and unwashed spent mushroom compost respectively. Main components of essential oil were carvacrol and gamma- trepenine. The highest level of carvacrol (62.10) and gamma-trepenine (32.05) were obtained in plants in substrate containing 40 and 20 % of washed spent mushroom respectively.
No hay cuña más dura que la del mismo palo. Una aproximación a la dictadura duvalierista en Haití
Authors: Millán Moncayo Márgara 
Published: July 2019

Haití, el país más pobre de América Latina, ocupa la parte occidental de la añorada isla La Hispañola, conquistada por el viejo mundo durante el siglo XVI. El dominio de Haití lo tuvieron los corsarios franceses desde muy temprano. En 1697 pasa a ser colonia francesa. Fue entonces poblada por esclavos negros traídos del África. Los españoles habían exterminado con singular violencia a los nativos aracucos.
Una mirada sobre el fracaso escolar en la transición al bachillerato
Authors: Romo Torres Tania Maria 
Published: July 2019

La educación es una pieza fundamental, que otorga recursos y oportunidades al individuo para alcanzar las metas deseadas en virtud del esfuerzo; por ello, en la actualidad, la educación se ha convertido en una herramienta indispensable para la vida laboral y social de los individuos; sin embargo, la tasa de deserción es preocupante, tanto para educadores como para economistas, ya que, al tratarse de un evento voluntario, amplía las brechas sociales, se mantienen los círculos de pobreza y desigualdad e impide la transformación social. De manera que el fracaso escolar trasciende el ámbito educativo y afecta, de uno u otro modo, a la sociedad en su conjunto.De aquí la importancia de su estudio, ya que, si la educación es la clave y solución de múltiples problemas sociales, culturales, políticos y económicos, se debe disminuir el riesgo de exclusión, lo que se logra si se conoce en detalle el fenómeno de fracaso escolar. Ahora bien, el mayor número de casos de absentismo, deserción precoz, bajo rendimiento académico, repitencia y conflicto escolar se presenta en grado sexto, ya que es el grado en el que se realiza el primer cambio profundo al Sistema educativo y, por ende, implica cambios significativos en la vida escolar del estudiante; por tanto, la necesidad de realizar un cuestionamiento sobre lo que sucede en este grado y estudiar la posición de distintos teóricos para analizar las posibles alternativas de solución a este fenómeno de fracaso escolar.
The Hungryalist Movement in Bengal: A Conversation with Malay Roychoudhury
Authors: Mitra Zinia , Sarangi Jaydeep 
Published: July 2019

Malay Roychoudhury (1939) is an Indian Bengali poet, playwright, short story writer, essayist and novelist who founded the Hungryalist movement in the 1960s which changed the course of avant-garde Bengali literature and painting. His best-known poetry collections are Medhar Batanukul Ghungur, Jakham and Matha Ketey Pathachhi Jatno korey Rekho; and his novels Dubjaley Jetuku Proshwas and Naamgandho. He has written more than hundred books. He was given the Sahitya Academy award, the Indian government's highest honour in the field, in 2003 for translating Dharamvir Bharati's Hindi fiction Suraj Ka Satwan Ghora. However, he declined to accept this award and others. This interview has been executed by the exchange of e mails with the activist-author.