bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term follow-up of pediatric head trauma patients treated at Mulago National Referral Hospital in Uganda
Authors: Vaca Silvia D. , Xu Linda W. , Nalwanga Juliet , Muhumuza Christine , Lerman Benjamin J. , Kiryabwire Joel , Ssenyonjo Hussein , Mukasa John , Muhumuza Michael , Haglund Michael , Grant Gerald 
Published: November 2018

OBJECTIVEThere is a paucity of literature on long-term neurosurgical outcomes in sub-Saharan Africa, and as neurosurgical services expand in each country, it would be beneficial to understand the impact of these services on the national population. Since follow-up can be inconsistent, the authors here used the novel method of telephone surveys to conduct the first-ever long-term follow-up in Uganda to elucidate the outcomes of pediatric head trauma patients treated at the national referral hospital.METHODSA prospectively maintained database of pediatric head trauma patients treated at the Mulago National Referral Hospital (MNRH) between 2014 and 2015 included 232 patients eligible for this study. Quality of life was assessed through phone surveys conducted by a Ugandan collaborator on site who performed all interviews with the guardian listed at the time of hospital admission, using each participant’s language.RESULTSPhone interviews were completed for 142 patients, resulting in a 61% response rate. Including inpatient deaths, the mortality rate was 10%. Almost half of the patients (48%) did not return to MNRH postdischarge, and 37% received no subsequent healthcare at all. Including inpatient deaths, the average Extended Glasgow Outcome Scale–Pediatric Revision (GOSE-Peds) scores for patients with severe, moderate, and mild head trauma were 5.68 ± 2.85, 4.79 ± 2.38, and 3.12 ± 2.08, respectively, at 1 year postinjury and 5.56 ± 2.58, 4.00 ± 2.45, and 2.21 ± 1.49, respectively, at 2 years postinjury.CONCLUSIONSThis first-ever long-term follow-up of pediatric head trauma patients in Uganda confirmed the feasibility of a novel phone follow-up method for patients throughout Uganda. The results at 2 years showed poor long-term recovery in patients who suffered moderate or severe head trauma but good recovery in patients who suffered mild head trauma. However, there was greater overall disability than that in comparable head trauma studies in the US. The current study lays the groundwork for phone follow-up in low- and middle-income countries as a viable way to obtain outcome data.
Deep brain stimulation for Gilles de la Tourette syndrome in children and youth: a meta-analysis with individual participant data
Authors: Coulombe Marie-Andrée , Elkaim Lior M. , Alotaibi Naif M. , Gorman Daniel A. , Weil Alexander G. , Fallah Aria , Kalia Suneil K. , Lipsman Nir , Lozano Andres M. , Ibrahim George M. 
Published: November 2018

OBJECTIVEGilles de la Tourette syndrome (GTS) is a disorder characterized by motor and vocal tics. Although by definition the onset of GTS is before age 18 years, clinical trials of deep brain stimulation (DBS) have been conducted only in adults. Using individual participant data (IPD) meta-analysis methodology, the current study investigated the safety and efficacy of DBS as a treatment for GTS in children and youth.METHODSA systematic review with no date or language restrictions was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. Three electronic databases were searched: PubMed, EMBASE, and Web of Science. From 843 articles screened, the IPD of 58 children and youth (ages 12–21 years) extracted from 21 articles were collected and analyzed. A mixed-effects univariable analysis followed by multivariable hierarchical regression was performed using change in the Yale Global Tic Severity Scale (YGTSS) score as the primary outcome and reported measures of comorbidities as secondary outcomes.RESULTSThe authors’ results showed an average improvement of 57.5% ± 24.6% across studies on the YGTSS. They also found that comorbid depression and stimulation pulse width each correlated negatively with outcome (p < 0.05). In patients with less severe GTS, greater improvements were evident following thalamic stimulation. More than one-quarter (n = 16, 27.6%) of participants experienced side effects, the majority of which were minor.CONCLUSIONSDBS in the pediatric population may be an effective option with a moderate safety profile for treatment of GTS in carefully selected children and youth. Large, prospective studies with long-term follow-up are necessary to understand how DBS influences tic symptoms and may alter the natural course of GTS in children.
Resistencias y costos unitarios de concretos fabricados con cementos utilizados en Huaraz, con agregados de la cantera Tacllán, y topexconcreto listo, Huaraz
Authors: Villegas Zamora Víctor , Corrales Picardo Miguel 
Published: November 2018

<p>La presente investigación ha tenido por objeto determinar y seleccionar la marca de cemento: Sol, Quisqueya, Inka empleando agregados de la cantera Tacllán, para la fabricación de concreto y topex-concreto listo; con lo cual busca lograr mayor resistencia a la compresión y optimizar los costos unitarios de fabricación en Huaraz. Para el efecto, obtenidos los agregados de la cantera, se determinaron sus características físicas y empleando el método del Instituto Americano del Concreto, se ha realizado el diseño de mezclas de concreto con relación agua-cemento, para asentamiento entre 3'' a 4''; para resistencias a compresión de 21 y 28 Mpa se elaboraron y ensayaron briquetas de concreto en la máquina a compresión uniaxial, calculándose las resistencias. Los costos unitarios se determinaron en base a la cantidad de materiales requeridos por yd3 de concreto y precios de mercado. Se determinó que, para concretos diseñados para 21 y 28 Mpa, con cemento Quisqueya se ha logrado resistencias de 41.48 y 42.42 Mpa y costos unitarios de 190.19 y 210.58 nuevos soles, respectivamente. Se reporta que, empleando cemento marca Quisqueya en la fabricación de concretos, se logra mayores resistencias y menores costos unitarios para resistencias de diseño 21 y 28 Mpa.</p>
Utilización de técnicas de minería de datos para la identificación de rasgos de comportamiento en procesos de aprendizaje colaborativo en modelos de e-learning y b-learning
Authors: Cobo Ortega Ángel , Nuñez Blas Pilar , Niquin Alayo Esmelin , Puelles Gonzales Franklin 
Published: November 2018

<p>Actualmente, las modalidades e-learning y b-learning son cada vez más utilizadas y se acumula una gran cantidad de información que es muy valiosa para analizar el comportamiento de los estudiantes. En estos sistemas de aprendizaje colaborativo se ofrece</p><p>una gran variedad de canales y espacios de trabajo para facilitar el intercambio de información y la comunicación entre los participantes, pero que resultan muy difíciles de analizar; aun con el uso de las herramientas estadísticas. Se utilizó técnicas de Minería de Datos y la metodología de Proceso de Análisis Jerárquico (AHP) para identificar los rasgos de comportamiento en el aprendizaje colaborativo, el seguimiento de las actividades, la participación en los foros y demás actividades a partir de información extraída de los logs que quedan en los servidores y de los informes de actividad que generan las plataformas de gestión de cursos virtuales. Se estudió, igualmente, la interactividad en estos sistemas con el Proceso de Análisis Jerárquico. Es por ello que utilizaremos en esta oportunidad Expert Choice, Weka, softwares de AHP, Minería de Datos que nos ayudará a cumplir nuestro propósito.</p>
Sur les indices des cristaux liquides : mesure par la méthode du prisme et étude théorique
Authors: Pellet Odette , Chatelain Pierre 
Published: November 2018

Les indices de trois corps nématiques, mesurés par la méthode du prisme en fonction de la température et pour deux longueurs d'onde, sont donnés pour les phases cristal liquide et liquide isotrope dans la première partie de ce travail.
Dans la seconde partie les divers modes de calcul du champ de polarisation moléculaire sont discutés. Partant de ce que, dans le cristal liquide, il existe des domaines de l'ordre de 1/10 de µ dans lesquels les molécules sont très sensiblement parallèles les unes aux autres, une modification au calcul classique de Lorentz-Lorenz est apportée ; elle conduit à une meilleure vérification expérimentale des résultats théoriques.
Dissolution d'une solution solide : étude théorique et expérimentale
Authors: Denis Jérôme , Michard Gil 
Published: November 2018

From a discussion of the equilibrium conditions of a water-solid solution system and the notion of congruent dissolution, we propose two different ways of reaching stable equilibrium.
We first assume congruent dissolution of the initial solid :
A B1-x Cx → A- + (l-x) B+ + xC+
and the reprecipitation of a new solid phase following the partition relation between water and precipitate :
|AC|/|AB| = D|C+|/|B+|
where |AC| and |AB| are the concentration of the two end members in the precipitate, |C+| and |B+| ion activities in solution and D the partition coefficient.
The first model is based on instantaneous equilibrium between water and precipitate, the second is a kinetic approach. Both tend towards thermodynamic equilibrium between water and the solid-solution. We have applied these models to experimental results obtained in the laboratory.
Hydrocompaction, dissolution, suffosion et soutirage. Contribution à la formation des dépressions fermées
Authors: Pellegrin Jean-Christophe , Salomon Jean-Noël 
Published: November 2018

Hydrocompaction, solution, suffosion and piping as processes of forming depression contours.
The authors of this note provide a definition for four processes (hydrocompaction, solution, suffosion, piping) which, although different, are likely to result in comparable surface morphologies, such as closed hollows. They attempt to clarify the specific features of each of these processes.
Flow-line Wandering in the Turbulent Solar Wind and Space Environment Forecasts
Authors: Ragot B. R. 
Published: November 2018

Abstract
Space environment forecasts are based on ab initio modeling of the solar wind (SW) wherein solar magnetic fields and plasmas are propagated from an initial/boundary model source surface in the lower solar corona out to 1 au. Testing of these space environment forecasts relative to in situ measurements at 1 au typically shows uncertainties in the arrival times of fast SW streams of the order of a day, with broad distributions, means/medians of the order of half a day, and large variations between models but no definite winner. Here the effect of flow-line (FL) wandering due to the higher frequency velocity fluctuations within the turbulent SW on the arrival-time statistics of parcels of SW plasma transiting through the inner heliosphere out to 1 au is evaluated for a range of cutoff timescales in the velocity fluctuations. Used for this evaluation are in situ SW velocity measurements onboard Wind at 1 au, detailed spectral analysis of these measurements, WKB extrapolations to the inner heliosphere and simple application of a newly extended theoretical calculation of the mean SWFL cross-flow and “flow-aligned” displacements from the measured spectra. It is found that the velocity fluctuations near 1 au have little effect on the arrival times. The effect of the velocity fluctuations increases sunward, however, to a level sufficient to explain the large and broadly distributed “uncertainties” found in the testing of the forecasts.
THE SOIL SCIENCE &amp; ARCHAEO-GEOPHYSICS ALLIANCE (SAGA): going beyond prospection
Authors: Cuenca-Garcia Carmen , Armstrong Kayt , Aidona Elina , De Smedt Philippe , Rosveare Anne , Rosveare Martin , Schneidhofer Petra , Wilson Clare , Faßbinder Jörg , Moffat Ian , Sarris Apostolos , Scheiblecker Marion , Jrad Abir , van Leusen Martijn , Lowe Kelsey 
Published: November 2018

Archaeological sites can be discovered and recorded in a high-resolution and non-invasive manner using geophysical methods. These measure the spatial variation of a range of physical properties of the soil which may be representative proxies of the subsurface archaeology. Less-invasive and cost-effective field procedures have become top-priority to mitigate the destructive effects on our cultural heritage from intensified land use, climate change and the current conflict panorama.
At a time when many organisations are investing in advanced geophysical equipment, a major problem is that our ability to fully interpret the information available from geophysical datasets is still very limited. This deficiency prevents geophysical survey moving beyond basic prospection and becoming a significant tool for answering nuanced questions about archaeology and their host landscapes. This limitation arises from an incomplete understanding of the relationship between soil properties and geophysical measurements. Bridging this gap requires multi-disciplinary teams, testing novel methods, plus scholarly discussion to collate the outcomes of projects on this topic. Overcoming these challenges is a prerequisite for maximising the costeffectiveness of geophysical methods, realising the expected benefits of technological investment and allowing broader utility of geophysical methods in the cultural heritage sector.
SAGA will build an international network of geophysicists, archaeologists, soil scientists and other experts to develop our capability to interpret geophysical data and promote research collaborations. Our vision is that after four years, SAGA will have created an environment within which emerging field procedures, enhanced data interpretation and a broader understanding of integrated geophysical methods can flourish.
Uptake and Clinical Utility of Multibiomarker Disease Activity Testing in the United States
Authors: Curtis Jeffrey R. , Xie Fenglong , Yang Shuo , Danila Maria I. , Owensby Justin K. , Chen Lang 
Published: November 2018

Objective.The clinical utility of the multibiomarker disease activity (MBDA) test for rheumatoid arthritis (RA) management in routine care in the United States has not been thoroughly studied.Methods.Using 2011–2015 Medicare data, we linked each patient with RA to their MBDA test result. Initiation of a biologic or Janus kinase (JAK) inhibitor in the 6 months following MBDA testing was described. Multivariable adjustment evaluated the likelihood of adding or switching biologic/JAK inhibitor, controlling for potential confounders. For patients with high MBDA scores who added a new RA therapy and were subsequently retested, lack of improvement in the MBDA score was evaluated as a predictor of future RA medication failure, defined by the necessity to change RA medications again.Results.Among 60,596 RA patients with MBDA testing, the proportion adding or switching biologics/JAK inhibitor among those not already taking a biologic/JAK inhibitor was 9.0% (low MBDA), 11.8% (moderate MBDA), and 19.7% (high MBDA, p < 0.0001). Similarly, among those already taking biologics/JAK inhibitor, the proportions were 5.2%, 8.3%, and 13.5% (p < 0.0001). After multivariable adjustment, referent to those with low disease MBDA scores, the likelihood of switching was 1.51-fold greater (95% CI 1.35–1.69) for patients with moderate MBDA scores, and 2.62 (2.26–3.05) for patients with high MBDA scores. Among those with high MBDA scores who subsequently added a biologic/JAK inhibitor and were retested, lack of improvement in the MBDA score category was associated with likelihood of future RA treatment failure (OR 1.61, 95% CI 1.27–2.03).Conclusion.The MBDA score was associated with both biologic and JAK inhibitor medication addition/switching and subsequent treatment outcomes.
Use of Organoids Technology on Study of Liver Malignancy
Authors: Joob Beuy , Wiwanitkit Viroj 
Published: November 2018

AbstractThe study on liver cancer has been performed in clinical medicine and medical science for a long time. Within the few recent years, there are many new emerging biomedical technologies that help better assess on the liver cancer. Of several new technologies, the advanced cell technologies for the assessment of liver cancer, organoids technology is very interesting. In fact, the organoids is an advanced cell research technique that can be useful for studying of many medical disorders. Organoids can be applied for study on the pathophysiology of many cancers. The application for studying on liver cancer is very interesting issue in hepatology. In this short article, the author summarizes and discusses on applied organoids technology for studying on various kinds of liver cancers. The application can be seen on primary hepatocellular carcinoma, metastatic cancer, cholangiocarcinoma, hepatoblastoma, as well as other rare liver cancers.
An Unusual Presentation of Prostate Carcinoma
Authors: Sadasivan Greeshma , Arul R , Prabaharan A 
Published: November 2018

AbstractProstate carcinoma is the second most common cancer among men worldwide. Although prostate carcinoma is common, its presentation resembling retroperitoneal fibrosis is uncommon. We report a patient with prostate carcinoma mimicking retroperitoneal fibrosis. An elderly male presenting in a volume overload state with features of obstructive uropathy was diagnosed as a case of prostate carcinoma. Magnetic resonance imaging was suggestive of retroperitoneal fibrosis. The presentation of prostate carcinoma as retroperitoneal fibrosis is rare.
The Correlation between the Level of Doxorubicin-Induced Cardiac Damage and Serum Soluble Fas in an Experimental Rat Model
Authors: Kose Dogan , Ozdemir Hulya , Celik Zeliha Esin , Unlu Ali , Artac Hasibe , Koksal Yavuz 
Published: November 2018

Abstract
Aim: This study was planned to research the relationship between doxorubicin cardiomyopathy and the soluble Fas (sFas) level. Materials and Methods: Two groups of rats were included in the study. The control group was given physiological saline, while the study group was given doxorubicin. The rats, whose blood samples were taken weekly, were sacrificed and their myocardial tissues were removed. The tissues were examined in terms of morphological changes and surface Fas expression, while the blood samples were examined in terms of sFas level. Results: In the study group, the sFas levels at 2nd–9th weeks were higher than those found at 1st week before administrating the drug, and the increase at 2nd–7th weeks was meaningful. In addition, sFas levels were gradually increased each week during 1st–5th weeks when compared to the values of a previous week, and the increase during the first 4 weeks was meaningful. After the 5th week, the values gradually decreased each week. The mean values of the study group at 1st–8th weeks were higher than those of the control group, and the increases at 2nd–8th weeks were meaningful. The severe forms of interfibrillar hemorrhage, vascular dilatation, myocardial necrosis, inflammatory infiltration, and splitting of muscle fibers occurred with 15, 15, 17.5, 20, and 22.5 mg/kg dose of medicine, respectively. Conclusions: As the tissue injury increased, the increasing cell-surface Fas expression and sFas plasma level at the acute phase of doxorubicin-related cardiotoxicity decreased. The sFas level determined at acute phase may be helpful in predicting the existing injuries and possible late-term problems.
Estructuras y significados de trayectorias manageriales en grandes empresas argentinas
Authors: Luci Florencia , Zangaro Marcela 
Published: November 2018

Este artículo indaga cómo quienes aspiran a ocupar puestos directivos en grandes empresas argentinas perciben y significan la competencia de la carrera managerial. Se busca explorar la relación compleja entre el modo en que las organizaciones son diagnosticadas y pensadas en términos objetivos, y cómo son diagnosticadas y pensadas en términos subjetivos, es decir, el modo de vivirlas y de percibir la propia experiencia laboral en diseños organizacionales específicos. Se realizó una investigación cualitativa en ocho grandes empresas de Argentina de diversos sectores y formas de propiedad donde se entrevistó a 88 managers y se realizaron 12 entrevistas en profundidad a los directores y responsables de recursos humanos así como a informantes clave. Identificamos que la competencia hacia la cima se significa como up or out, constricción elusiva y dinámica tradicional, y que la dinámica temporal de la carrera se significa en términos de estancamiento, turning points o status passages. La inclusión de estos significados y apreciaciones subjetivas, junto con los elementos objetivos que derivan del diseño de la organización, son fundamentales para un análisis de las organizaciones como fenómenos complejos.
Le projet d’exploration au prisme d’une théorie sociale de l’apprentissage
Authors: Bonnet Emmanuel , Lièvre Pascal , Godé Cécile 
Published: November 2018

L’objet de cet article est d’étudier un projet d’exploration en mobilisant une théorie sociale de l’apprentissage initialement associée à la communauté de pratique (Wenger, 1998). D’une part, les projets d’exploration sont abordés sous l’angle de l’apprentissage collectif plutôt que de la coordination. D’autre part, l’apprentissage situé ne se réduit pas aux communautés de pratique (Amin et Roberts, 2008). Nous proposons d’articuler projet d’exploration et théorie sociale de l’apprentissage et posons la question suivante : quels enseignements théoriques et empiriques pouvons-nous dégager de l’étude d’une équipe projet d’exploration à travers le prisme d’une théorie sociale de l’apprentissage ? A partir du cas d’une simulation d’exploration martienne, nous montrons que le projet peut être abordé comme une dynamique de structuration qui articule sens, participation et réification. Nos résultats nous permettent de mieux comprendre l’apprentissage collectif en situation dans des projets d’exploration.
Le rôle des routines dans la construction des capacités dynamiques : le cas d’une entreprise dans le secteur touristique
Authors: Altintas Gulsun 
Published: November 2018

Nous mobilisons le concept de routine afin de saisir la récurrence du processus de construction des capacités dynamiques. Nous adoptons une démarche d’étude de cas au sein d’un tour-opérateur. Notre méthode qualitative permet d’identifier deux capacités dynamiques : la première est liée à la diversification des activités et la deuxième est liée au développement du réseau commercial. Nos résultats soulignent l’importance des routines existantes et nouvelles dans la construction des capacités dynamiques. Ils montrent également que le processus de construction - qui est différent en fonction de la nature émergente ou délibérée de l’opportunité - résulte de la routinisation d’une expérimentation réussie.
Children in the Ancient Near Eastern Household. By Kristine Garroway
Authors: Broida Marian 
Published: November 2018

Children in the Ancient Near Eastern Household. By Kristine Garroway. Explorations in Ancient
Near Eastern Civilizations, vol. 3. Winona Lake, Ind.: Eisenbrauns, 2014. Pp. xvii + 374. $57.50.
Couched in Death: Klinai and Identity in Anatolia and Beyond. By Elizabeth P. Baughan
Authors: Simpson Elizabeth 
Published: November 2018

Couched in Death: Klinai and Identity in Anatolia and Beyond. By Elizabeth P. Baughan. Wisconsin
Studies in Classics. Madison: University of Wisconsin Press, 2013. Pp. xvii + 487, illus. $65.