bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sympathetic Solar Eruption on 2024 February 9
Authors: Li Shu-Yue , Zhang Qing-Min , Ying Bei-Li , Feng Li , Su Ying-Na , Lin Mu-Sheng , Zhang Yan-Jie 
Published: December 2024

Abstract
In this paper, we perform a follow-up investigation of the solar eruption originating from active region 13575 on 2024 February 9. The primary eruption of a hot channel generates an X3.4 class flare, a full-halo coronal mass ejection (CME), and an extreme-ultraviolet (EUV) wave. Interaction between the wave and a quiescent prominence (QP) leads to a large-amplitude, transverse oscillation of QP. After the transverse oscillation, QP loses equilibrium and rises up. The ascending motion of the prominence is coherently detected and tracked up to ∼1.68 R
⊙ by the Solar UltraViolet Imager onboard the GOES-16 spacecraft and up to ∼2.2 R
⊙ by the Solar Corona Imager (SCI_UV) of the Lyα Solar Telescope onboard the ASO-S spacecraft. The velocity increases linearly from 12.3 to 68.5 km s−1 at 18:30 UT. The sympathetic eruption of QP drives the second CME with a typical three-part structure. The bright core comes from the eruptive prominence, which could be further observed up to ∼3.3 R
⊙ by the Large Angle Spectroscopic Coronagraph onboard the Solar and Heliospheric Observatory mission. The leading edge of the second CME accelerates continuously from ∼120 to ∼277 km s−1. The EUV wave plays an important role in linking the primary eruption with the sympathetic eruption.
Nanoarchitectonics in immobilization of DNT/TNT specific binding peptides on laser-induced graphene
Authors: Kol Seda , Kocaman Kabil Fatmanur , Aydemir Nihan , Oral Ahmet Yavuz 
Published: December 2024

Abstract
Bio/chemical sensors require high selectivity for specific targets. Carbon nanomaterials, especially graphene-based materials, are preferred in sensors due to their high surface area, superior electrical conductivity, mechanical strength, and flexibility. In this study, DNT-bp (Dinitrotoluene binding peptide) and TNT-bp (Trinitrotoluene binding peptide) were immobilized on LIG (Laser-induced graphene) films through covalent and non-covalent interactions. EDC (1-ethyl-3-3-dimethylaminopropyl carbodiimide hydrochloride) is used to activate carboxylic acid groups, which then react with NHS (N-hydroxysuccinimide) to form NHS esters, facilitating the binding of amine-containing peptides to the LIG surface. XPS analysis of LIG films functionalized with EDC+NHS shows a decrease in COOH (carboxyl) and an increase in C–N/C=N/C–O groups. N1s peak at high-resolution XPS spectrum indicates that DNT-bp immobilization leads to higher elimination of NHS-esters, resulting in fewer N-C=O (amide) functional groups and more protonated nitrogen, which suggests that DNT-bp immobilization is more effective than TNT-bp immobilization. The findings suggest that LIG-based sensors provide a cost-effective platform for the detection of DNT (2,4-dinitrotoluene) and 2,4,6-trinitrotoluene (TNT). Further advancements in LIG-based biosensors may enable their broader application in security, environmental monitoring, and health diagnostics.
Electrical diagnostics of dielectric barrier discharge for optimal power determination
Authors: Singh Akhilesh Kumar , Guragain Rajesh Prakash , Shrestha Asmita , Chhetri Ganesh Kuwar , Dhungana Santosh , Baniya Hom Bahadur , Subedi Deepak Prasad , Joshi Ujjwal Man 
Published: December 2024

Abstract
This study presents a comprehensive theoretical and experimental analysis to determine the optimum power for a Cold Atmospheric Pressure Plasma (CAPP) system using a Dielectric Barrier Discharge (DBD) reactor. The investigation reveals that maximum power is consumed at a specific discharge gap within the DBD reactor. Power was computed across varying discharge widths, ranging from 1.0 mm to 5.0 mm, for a fixed input sinusoidal voltage with a frequency of 50 Hz. Additionally, power was calculated for different input voltages at a constant discharge width. The power consumption of the reactor was determined using the Lissajous figure method and voltage-current characteristics. Both experimental and theoretical studies identified that a discharge width of 3.0 mm is optimal for minimizing power consumption in the reactor. The theoretical predictions, based on an electrical circuit model, aligned well with experimental findings using Lissajous figures and current–voltage measurements. Moreover, the study examined the variation in the number of discharge filaments per cycle at different input voltages and discharge widths, demonstrating that an increase in discharge width results in a linear decrease in the number of filaments, while higher input voltage increases filament density. These findings highlight the importance of optimizing both discharge width and input voltage to achieve efficient power usage in plasma systems. This research contributes to the development of energy-efficient plasma technologies by providing critical insights into the power optimization of CAPP in DBD reactors, with potential applications in various industrial and agricultural processes.
Transport signatures of phase fluctuations in superconducting qubits
Authors: Wisne M , Deng Y , Cansizoglu H , Kopas C , Mutus J Y , Chandrasekhar V 
Published: December 2024

Abstract
Josephson junctions supply the nonlinear inductance element in superconducting qubits. In the widely used transmon configuration, where the junction is shunted by a large capacitor, the low charging energy minimizes the sensitivity of the qubit to charge noise while maintaining the necessary anharmonicity to qubit states. We report here low-frequency transport measurements on small standalone junctions and identically fabricated capacitively-shunted junctions that show two distinct features normally attributed to small capacitance junctions near zero bias: reduced switching currents and prominent finite resistance associated with phase diffusion in the current–voltage characteristic. Our transport data reveals the existence of phase fluctuations in transmons arising from intrinsic junction capacitance.
Lasers, Light, and Energy-Based Devices in Plastic Surgery: A 3-Year Review of a Resident Cosmetic Clinic Experience
Authors: Nadarajan Vidhya , Thota Bhavana , Dogaroiu Anca , Kim Lauren , Niksic Amor , Barillas Jennifer , Hoopman John , Amirlak Bardia , Kenkel Jeffrey M 
Published: December 2024

Abstract

Background
The increasing utilization of laser and light-based technologies in plastic surgery has heightened the need for comprehensive training programs within residency programs, allowing trainees to remain competitive in the cosmetic medicine field.

Objectives
This review intends to describe our trainees’ experience with lasers in their last 2 years of training while participating in their resident cosmetic clinic.

Methods
This retrospective chart review examines laser procedures conducted from 2021 to 2023 within the Resident Cosmetic Clinic at the study institution. Data were gathered from internal records and patient charts, focusing on demographics, procedure types, complication rates, and training structures.

Results
This study analyzed 162 resident cosmetic laser, light-based device, and radiofrequency cases between 2021 and 2023. There were 90 patients with an average age of 46.8 years with the majority being females (95.6%). Intense pulsed light was the most frequently used modality used in 46.01% of procedures. The overall complication rate was 6.17%.

Conclusions
The findings suggest that resident laser clinics, under proper supervision, provide a safe and effective training ground for future plastic surgeons. This study underscores the need for standardized and comprehensive education to enhance resident knowledge and skills in laser and other energy-based devices.

Level of Evidence: 3 (Therapeutic)
Partially factorized variational inference for high-dimensional mixed models
Authors: Goplerud M , Papaspiliopoulos O , Zanella G 
Published: December 2024

Abstract
While generalized linear mixed models are a fundamental tool in applied statistics, many specifications, such as those involving categorical factors with many levels or interaction terms, can be computationally challenging to estimate due to the need to compute or approximate high-dimensional integrals. Variational inference is a popular way to perform such computations, especially in the Bayesian context. However, naive use of such methods can provide unreliable uncertainty quantification. We show that this is indeed the case for mixed models, proving that standard mean-field variational inference dramatically underestimates posterior uncertainty in high-dimensions. We then show how appropriately relaxing the mean-field assumption leads to methods whose uncertainty quantification does not deteriorate in high-dimensions, and whose total computational cost scales linearly with the number of parameters and observations. Our theoretical and numerical results focus on mixed models with Gaussian or binomial likelihoods, and rely on connections to random graph theory to obtain sharp high-dimensional asymptotic analysis. We also provide generic results, which are of independent interest, relating the accuracy of variational inference to the convergence rate of the corresponding coordinate ascent algorithm that is used to find it. Our proposed methodology is implemented in the R package vglmer. Numerical results with simulated and real data examples illustrate the favourable computation cost versus accuracy trade-off of our approach compared to various alternatives.
Association Between Serum Ustekinumab Concentrations and Endoscopic Disease Activity in Moderate-to-Severe Crohn’s Disease Patients
Authors: Di Fonzo David M P , Alabdulkarim Balqis , Yanofsky Russell , Abduallah Yaqeen , Golovics Petra , Lakatos Peter L , Bitton Alain , Wild Gary , Afif Waqqas , Bessissow Talat 
Published: December 2024

Abstract

Background/Aims
The role of ustekinumab therapeutic drug monitoring in patients with Crohn’s disease (CD) remains ambiguous. Examination of the association serum ustekinumab concentrations and endoscopic outcomes has yielded inconsistent results. Our study examined whether serum ustekinumab concentrations were associated with endoscopic healing in patients with moderate-to-severe CD.

Methods
This was a cross-sectional study of adult patients with CD on maintenance ustekinumab. Patients were included if they had serum ustekinumab concentrations and endoscopic evaluation taken within 4 months of each other. Endoscopic healing was defined as absence of ulceration on endoscopy or Simplified Endoscopic Score for Crohn’s disease (SES-CD) &lt; 3. Quartile analysis of drug levels was performed, and receiver operating characteristic curve was calculated. Multivariate logistic regression assessed for the probability of endoscopic healing based on serum ustekinumab concentration.

Results
Seventy-four patients were included in the final analysis. The mean serum ustekinumab concentration of the population was 6.10 mcg/mL. Serum ustekinumab concentration did not predict endoscopic remission based on either the absence of ulceration or SES-CD &lt; 3. There was no difference in the frequency of ulceration at increasing serum ustekinumab concentrations. There was no threshold serum ustekinumab concentration associated with the absence of ulceration (area under the curve [AUC] = 0.50) or SES-CD &lt; 3 (AUC = 0.49).

Conclusions
Our study found no association between serum ustekinumab concentrations and endoscopic remission in patients with CD. Exploration of mechanisms accounting for this lack of association is warranted.
Glucagon-like peptide-1 receptor agonists for the treatment of obstructive sleep apnea: a meta-analysis
Authors: Li Mingxia , Lin Hong , Yang Qianru , Zhang Xiaolong , Zhou Qiong , Shi Jiankuan , Ge Fangfang 
Published: December 2024

Abstract

Study Objectives
Obstructive sleep apnea (OSA) is characterized by disordered breathing during sleep and is associated with major cardiovascular complications. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) as an important treatment for obesity and diabetes mellitus show promising therapeutic prospects in OSA. We conducted a meta-analysis to evaluate the effect of GLP-1RA intervention in OSA individuals.

Methods
We searched the PubMed and Web of Science databases (published until July 1, 2024). The included studies evaluated the GLP-1RA in OSA individuals and the efficacy outcomes measured by the apnea-hypopnea index (AHI).

Results
Six studies with a total of 1067 participants enrolled. GLP-1RA significantly decreased AHI with an estimated treatment difference of −9.48 events per hour (95% confidence interval [CI] =  −12.56 to − 6.40, I2 = 92%). The change in weight was −10.99 kg and body mass index (BMI) was –1.60 kg/m2. The mean difference in systolic blood pressure was –4.81 mmHg and in diastolic blood pressure was –0.32 mmHg. Tirzepatide significantly reduced AHI more than liraglutide with an estimated treatment difference of –21.86 events per hour (95% CI = –25.93 to –17.79) vs –5.10 events per hour (95% CI = –6.95 to –3.26). Obese individuals experienced a more significant decrease in AHI with an estimated treatment difference of –12.93 events per hour vs –4.31 events per hour. The application of continuous positive airway pressure and the duration of follow-up did not affect the therapeutic effect.

Conclusions
GLP-1RA could significantly reduce the severity of OSA, and also lead to weight loss and lower blood pressure. Further high-quality randomized controlled trials (RCTs) are needed to explore different GLP-1RA treatments and durations in OSA and identify participant subgroups that may benefit the most.

Clinical Trial
NA.
Evidence-Based Clinical Utility of Heart Rate Variability Across Populations, Including Long COVID
Authors: Steere Karin 
Published: December 2024

Purpose:
Heart rate variability (HRV) has been used for decades as a tool for measuring systemic health through the autonomic nervous system (ANS). The purpose of this paper was to examine the literature on HRV and to investigate its use in the long COVID (LC) population.

Summary of Key Points:
Measurement devices vary significantly in their validity and reliability when compared with the gold standard of electrocardiogram (ECG). Wrist and hand devices typically demonstrate diminished validity for capturing HRV signal, while chest strap devices often exhibit high reliability and validity. Lack of transparency in third-party software used to clean and analyze HRV data makes assessment for accuracy problematic. This is of particular concern when single beat miscalculations can result in significantly dissimilar output. The conditions under which HRV data are collected, such as natural or paced breathing, activity intensity, and patient position, can dramatically affect HRV readings. While some individual HRV metrics have consistently been shown to reflect certain components of the ANS, such as high-frequency power as a measure of parasympathetic function, the meaning of other metrics is less clear.

Recommendations for Clinical Practice:
Heart rate variability can be an extraordinarily valuable tool to measure systemic function. However, it is recommended that clinicians be judicious in the interpretation of HRV, considering inconsistencies in presentation. This is particularly true in LC, where individual HRV varies greatly. In all populations, clinicians should consider using valid devices to assess trends in HRV values over time, along with consideration of unique physical conditions.
Suprachoroidal Space in Rhegmatogenous Retinal Detachment Assessed with Optical Coherence Tomography: Implications for Potential Future Therapeutic Interventions
Authors: Jung Katherine L. , Pecaku Aurora , Demian Sueellen , Pimentel Miguel Cruz , Melo Isabela Martins , Muni Rajeev H. 
Published: December 2024

Purpose:
To comprehensively investigate the suprachoroidal space (SCS) in the context of rhegmatogenous retinal detachment (RRD) using swept-source optical coherence tomography (SS-OCT).

Methods:
We conducted a post hoc analysis of 90 consecutive patients with a primary RRD. Baseline SS-OCT scans were graded for the presence and thickness of the suprachoroidal space. Available scans of the fellow eye were graded for comparison.

Results:
The suprachoroidal space was visible in 31.6% (24/76) of gradable RRD scans, with a mean thickest location measuring 67.0µm (SD 25.9), mean thinnest location of 33.8µm (SD 11.1), and mean average thickness of 50.0µm (SD 16.8). Additionally, the SCS was detectable in 28.3% (13/46) of available fellow eye scans, with a mean thickest location measuring 47.0µm (SD 41.7), thinnest location of 25.2µm (SD 27.6) and mean average thickness of 35.8µm (SD 31.4). A statistically significant difference was found between RRD and fellow eyes in all measurements of SCS thickness.

Conclusion:
In RRD, the suprachoroidal space serves as a crucial fluid reservoir influenced by dynamic shifts in intraocular hydrostatic and oncotic pressures. We found significant SCS engorgement in RRD eyes compared to fellow eyes, which may facilitate intra-SCS therapies such as suprachoroidal viscopexy (SCVEXY) or other pharmacologic interventions.
Adrenal Cortical Carcinoma Presenting as CSCR
Authors: Gohari A. Reza , Modjtahedi Sara P. , Telander Caleb R. , Kong MaxX. 
Published: December 2024

Purpose:
We describe a case of bilateral chronic central serous chorioretinopathy (CSCR) secondary to adrenal cortical carcinoma.

Methods:
Case report of a 70-year-old Hispanic man presenting with bilateral multifocal CSCR.

Results:
Clinical findings of bilateral chronic CSCR along with 160 µm of subretinal fluid (SRF) and choroidal thickness greater than 400 µm without enhanced depth optical coherence tomography was noted in a patient presenting with distortion in vision in both eyes and weight gain of 15 pounds, weakness, and fatigue starting 8 months prior. Further endocrine testing showed an elevated 24-hour urinary free cortisol level of 137 µg with no change in serum cortisol levels following low-dose dexamethasone suppression test and undetectable serum adrenocorticotropic hormone (ACTH) levels consistent with ACTH-independent Cushing’s syndrome. Imaging of the abdomen revealed heterogeneously enhancing masses, and biopsy of the adrenal tumor led to the diagnosis of adrenal cortical carcinoma. He died 3 weeks after starting hospice care, and only completed one round of chemotherapy.

Conclusion:
Adrenal tumors including adrenal cortical carcinoma may present as bilateral chronic central serous chorioretinopathy.
Differentiating Depressive Symptoms From Side Effects in Individuals With Major Depressive Disorder With Postpartum Onset
Authors: Pulido Christine M. , Walson Ifeanyi S. , Yang Amy , Stika Catherine S. , Sit Dorothy K. , Wisner Katherine L. 
Published: December 2024

Abstract

Purpose
Somatic symptoms are commonly seen in major depressive disorder (MDD) with postpartum onset and can be similar to side effects of antidepressant medications. The aim of this study is to determine whether the decline in depressive symptoms measured by the Structured Interview Guide for the Hamilton Depression Rating Scale with Atypical Depression Supplement (SIGH-ADS) is significantly associated with the decrease in somatic symptoms identified by the Asberg scale.

Methods
A secondary analysis of data from a randomized controlled trial was conducted. The original 8-week trial included 62 participants and assessed the efficacy of sertraline versus estradiol transdermal patches and their respective placebos for MDD with postpartum onset. The SIGH-ADS scale was used to assess depression severity and the Asberg scale was used to evaluate treatment emergent side effects, defined as an increase of ≥2 from baseline measures. Correlation analyses were performed between total scale scores. The scales were compared to establish symptoms, which overlapped across scales versus symptoms, which were unique to each scale.

Results
Positive correlations were observed between the SIGH-ADS and Asberg scales and across the 8-week trial in all 3 treatment groups (correlation coefficient range 0.468–0.712). Headache was the most frequent treatment emergent side effect (10 occurrences). Fourteen symptoms were found to overlap between the 2 scales.

Conclusions
These findings underscore the importance of reviewing somatic symptoms before administering medication to discern true treatment emergent side effects, especially in populations recovering from labor and delivery. Somatic symptoms decline in parallel with depressive symptom scores during treatment, suggesting they are indicative of underlying illness rather than side effects.
Effect of Self-efficacy, Disease Perception, Social Support, Anxiety, and Depression on Self-management in Young Patients With Stroke
Authors: Zhang Rongfang , Li Xiaojing , Luo Huanli , Niu Jiangtao , Zhang Huimin 
Published: December 2024

ABSTRACT

BACKGROUND: Better self-management of chronic diseases may benefit patient functional status, medication effectiveness, lifestyle, and psychosocial health. Self-efficacy, disease perception, social support, anxiety, and depression are determinants of self-management behaviors in individuals with chronic illnesses. There remains a gap in the empirical exploration of the influence of these factors on self-management behaviors in young Chinese stroke survivors. This study examined how these factors affect specific self-management behaviors. METHODS: Validated instruments were used to evaluate patient self-efficacy, disease perception, social support, anxiety, and depression in a cross-sectional study. Structural equation modeling was used to examine the hypothesis. RESULTS: Self-efficacy and social support showed a positive correlation with self-management (0.421 and 0.446, respectively; P < .001). Disease perception, anxiety, and depression were negatively correlated with self-management (−0.158 and −0.336, respectively; P < .05). The structural equation model fit the data very well; social support had a direct positive effect on self-management (t = 3.002, P < .05) and self-efficacy (t = 5.773, P < .001). However, the presence of social support had a positive impact on reducing anxiety and depression (t = −5.046, P < .001). Furthermore, self-efficacy positively affected self-management (t = 1.226, P < .05), whereas anxiety and depression (t = −1.190, P < .05) and disease perception (t = −1.068, P < .05) had adverse effects on self-management. CONCLUSION: Medical staff and caregivers can improve patient self-management by helping them recognize the disease, reducing negative perceptions, communicating more for better understanding and care, intervening in anxiety and depression, and promoting mental health. This is especially important for young stroke patients.