bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Deep Eastern Boundary Current in the Chile Basin
Authors: Schulze Chretien Lena M. , Speer Kevin 
Published: November 2018

AbstractHydrographic data and tracers from several ship‐based sections show the location and structure of a deep eastern boundary current in the Chile Basin. The current is centered above the Peru‐Chile Trench at 2,500–3,400 m and transports up to 6 Sv of low‐potential vorticity, high‐silicate water south toward Drake Passage. Deep current velocities from direct Lowered Acoustic Doppler Current Profiler measurements are up to about 15 cm/s southward. The hydrographic data, as well as potential vorticity and silicate distributions, show that the current is comprised to a large extent of flow from the west moving along the southern flank of the Sala y Gomez Ridge and Nazca Ridge, and to a lesser extent from a flow along the eastern boundary entering directly from the Panama Basin. At the southern edge of the Chile Trench, the current weakens and partly turns offshore to cross the Chile Ridge through a complex region of passages. Above the southern flank of the Chile Rise the flow joins a broader eastward flow; together, these waters return to the eastern boundary before entering Drake Passage.
Seasonality of Freshwater in the East Greenland Current System From 2014 to 2016
Authors: Le Bras Isabela Alexander‐Astiz , Straneo Fiamma , Holte James , Holliday N. Penny 
Published: November 2018

AbstractThe initial 2 years of Overturning in the Subpolar North Atlantic Program mooring data (2014–2016) provide the first glimpse into the seasonality of freshwater in the complete East Greenland Current system. Using a set of eight moorings southeast of Greenland at 60∘ N, we find two distinct, persistent velocity cores on the shelf and slope. These are the East Greenland Coastal Current, which carries cold, fresh water from the Arctic and Greenland along the shelf, and the East Greenland/Irminger Current over the slope, which is a combination of cold, fresh waters and warm, salty waters of Atlantic origin. Together, these currents carry 70% of the freshwater transport across the subpolar North Atlantic east of Greenland. The freshwater transport referenced to a salinity of 34.9 is approximately equipartitioned between the coastal current (East Greenland Coastal Current) and the fresh portion of the slope current (East Greenland Current), which carry 42 ± 6 and 32 ± 6 mSv, respectively. The coastal and slope current freshwater transports have staggered seasonality during the observed period, peaking in December and March, respectively, suggesting that summer surveys have underestimated freshwater transport in this region. We find that the continental slope is freshest in the winter, when surface cooling mixes freshwater off the shelf. This previously unmeasured freshwater over the slope is likely to enter the Labrador Sea downstream, where it can impact deep convection.
Mutation landscape in patients with myelofibrosis receiving ruxolitinib or hydroxyurea
Authors: Pacilli Annalisa , Rotunno Giada , Mannarelli Carmela , Fanelli Tiziana , Pancrazzi Alessandro , Contini Elisa , Mannelli Francesco , Gesullo Francesca , Bartalucci Niccolò , Fattori Giuditta Corbizi , Paoli Chiara , Vannucchi Alessandro M. , Guglielmelli Paola 
Published: November 2018

AbstractRefractoriness to ruxolitinib in patients with myelofibrosis (MF) was associated with clonal evolution; however, whether genetic instability is promoted by ruxolitinib remains unsettled. We evaluated the mutation landscape in 71 MF patients receiving ruxolitinib (n = 46) and hydroxyurea (n = 25) and correlated with response. A spleen volume response (SVR) was obtained in 57% and 12%, respectively. Highly heterogenous patterns of mutation acquisition/loss and/or changes of variant allele frequency (VAF) were observed in the 2 patient groups without remarkable differences. In patients receiving ruxolitinib, driver mutation type and high-molecular risk profile (HMR) at baseline did not impact on response rate, while HMR and sole ASXL1 mutations predicted for SVR loss at 3 years. In patients with SVR, a decrease of ≥ 20% of JAK2V617F VAF predicted for SVR duration. VAF increase of non-driver mutations and clonal progression at follow-up correlated with SVR loss and treatment discontinuation, and clonal progression also predicted for shorter survival. These data indicate that (i) ruxolitinib does not appreciably promote clonal evolution compared with hydroxyurea, (ii) VAF increase of pre-existing and/or (ii) acquisition of new mutations while on treatment correlated with higher rate of discontinuation and/or death, and (iv) reduction of JAK2V617F VAF associated with SVR duration.
Preclinical development of a microRNA-based therapy for intervertebral disc degeneration
Authors: Ji Ming-liang , Jiang Hua , Zhang Xue-jun , Shi Pei-liang , Li Chao , Wu Hao , Wu Xiao-tao , Wang Yun-tao , Wang Chen , Lu Jun 
Published: November 2018

AbstractUnderstanding the molecular mechanisms regulating the maintenance and destruction of intervertebral disc may lead to the development of new therapies for intervertebral disc degeneration (IDD). Here we present evidence from miRNA microarray analyses of clinical data sets along with in vitro and in vivo experiments that miR-141 is a key regulator of IDD. Gain- and loss-of-function studies show that miR-141 drives IDD by inducing nucleus pulposus (NP) apoptosis. Furthermore, miR-141 KO in mice attenuated spontaneous and surgically induced IDD. Mechanistically, miR-141 promotes IDD development by targeting and depleting SIRT1, a negative regulator of NF-κB pathway. Therapeutically, upregulation or downregulation of miR-141 by nanoparticle delivery in IDD model aggravated or alleviated experimental IDD, respectively. Our findings reveal a novel mechanism by which miR-141, in part, promotes IDD progression by interacting with SIRT1/NF-κB pathway. Blockade of miR-141 in vivo may serve as a potential therapeutic approach in the treatment of IDD.
Cortical beta power reflects decision dynamics and uncovers multiple facets of post-error adaptation
Authors: Fischer Adrian G. , Nigbur Roland , Klein Tilmann A. , Danielmeier Claudia , Ullsperger Markus 
Published: November 2018

AbstractAdapting to errors quickly is essential for survival. Reaction slowing after errors is commonly observed but whether this slowing is adaptive or maladaptive is unclear. Here, we analyse a large dataset from a flanker task using two complementary approaches: a multistage drift-diffusion model, and the lateralisation of EEG beta power as a time-resolved index of choice formation. Fitted model parameters and their independently measured neuronal proxies in beta power convergently show a complex interplay of multiple mechanisms initiated after mistakes. Suppression of distracting evidence, response threshold increase, and reduction of evidence accumulation cause slow and accurate post-error responses. This data provides evidence for both adaptive control and maladaptive orienting after errors yielding an adaptive net effect – a decreased likelihood to repeat mistakes. Generally, lateralised beta power provides a non-invasive readout of action selection for the study of speeded cognitive control processes.
Self-assembled nematic colloidal motors powered by light
Authors: Yuan Ye , Abuhaimed Ghaneema N. , Liu Qingkun , Smalyukh Ivan I. 
Published: November 2018

AbstractBiological motors are marvels of nature that inspire creation of their synthetic counterparts with comparable nanoscale dimensions, high efficiency and diverse functions. Molecular motors have been synthesized, but obtaining nanomotors through self-assembly remains challenging. Here we describe a self-assembled colloidal motor with a repetitive light-driven rotation of transparent micro-particles immersed in a liquid crystal and powered by a continuous exposure to unstructured ~1 nW light. A monolayer of azobenzene molecules defines how the liquid crystal’s optical axis mechanically couples to the particle’s surface, as well as how they jointly rotate as the light’s polarization changes. The rotating particle twists the liquid crystal, which changes polarization of traversing light. The resulting feedback mechanism yields a continuous opto-mechanical cycle and drives the unidirectional particle spinning, with handedness and frequency robustly controlled by polarization and intensity of light. Our findings may lead to opto-mechanical devices and colloidal machines compatible with liquid crystal display technology.
Interaction paths promote module integration and network-level robustness of spliceosome to cascading effects
Authors: Guimarães Paulo R. , Pires Mathias M. , Cantor Maurício , Coltri Patricia P. 
Published: November 2018

AbstractThe functionality of distinct types of protein networks depends on the patterns of protein-protein interactions. A problem to solve is understanding the fragility of protein networks to predict system malfunctioning due to mutations and other errors. Spectral graph theory provides tools to understand the structural and dynamical properties of a system based on the mathematical properties of matrices associated with the networks. We combined two of such tools to explore the fragility to cascading effects of the network describing protein interactions within a key macromolecular complex, the spliceosome. UsingS.cerevisiaeas a model system we show that the spliceosome network has more indirect paths connecting proteins than random networks. Such multiplicity of paths may promote routes to cascading effects to propagate across the network. However, the modular network structure concentrates paths within modules, thus constraining the propagation of such cascading effects, as indicated by analytical results from the spectral graph theory and by numerical simulations of a minimal mathematical model parameterized with the spliceosome network. We hypothesize that the concentration of paths within modules favors robustness of the spliceosome against failure, but may lead to a higher vulnerability of functional subunits, which may affect the temporal assembly of the spliceosome. Our results illustrate the utility of spectral graph theory for identifying fragile spots in biological systems and predicting their implications.
Advanced spectroscopy-based phenotyping offers a potential solution to the ash dieback epidemic
Authors: Villari Caterina , Dowkiw Arnaud , Enderle Rasmus , Ghasemkhani Marjan , Kirisits Thomas , Kjær Erik D. , Marčiulynienė Diana , McKinney Lea V. , Metzler Berthold , Muñoz Facundo , Nielsen Lene R. , Pliūra Alfas , Stener Lars-Göran , Suchockas Vytautas , Rodriguez-Saona Luis , Bonello Pierluigi , Cleary Michelle 
Published: November 2018

AbstractNatural and urban forests worldwide are increasingly threatened by global change resulting from human-mediated factors, including invasions by lethal exotic pathogens. Ash dieback (ADB), incited by the alien invasive fungus Hymenoscyphus fraxineus, has caused large-scale population decline of European ash (Fraxinus excelsior) across Europe, and is threatening to functionally extirpate this tree species. Genetically controlled host resistance is a key element to ensure European ash survival and to restore this keystone species where it has been decimated. We know that a low proportion of the natural population of European ash expresses heritable, quantitative resistance that is stable across environments. To exploit this resource for breeding and restoration efforts, tools that allow for effective and efficient, rapid identification and deployment of superior genotypes are now sorely needed. Here we show that Fourier-transform infrared (FT-IR) spectroscopy of phenolic extracts from uninfected bark tissue, coupled with a model based on soft independent modelling of class analogy (SIMCA), can robustly discriminate between ADB-resistant and susceptible European ash. The model was validated with populations of European ash grown across six European countries. Our work demonstrates that this approach can efficiently advance the effort to save such fundamental forest resource in Europe and elsewhere.
The role of chamaejasmine in cellular apoptosis and autophagy in MG-63 cells
Authors: Yang Dawei , Zhang Hao , Wu Jianjun , Ma Ruishuang , Li Zongyu , Wang Kunzheng , Yang Fan 
Published: November 2018

Abstract
Background: Osteosarcoma (OS) is the most common malignant neoplasm in children and adolescents with a very high propensity for local invasion and poor response to current therapy. Anti-cancer effect of chamaejasmine is newly discovered from Stellera chamaejasmine L. Our study focuses on investigating the effect of chamaejasmine on the cellular apoptosis, proliferation, autophagy, and the underlying mechanisms in MG-63.
Methods: Our study investigated the concentration of chamaejasmine in MG-63 cells by MTT and verified that chamaejasmine inhibited cell invasion by transwell. We also used Hoechst staining as well as apoptotic associated-proteins in MG-63 cells. Meanwhile, we also detected the lysophagesome and autophagsome by Lysotracker. Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) knockdown was performed with siRNA.
Results: Our results show that chamaejasmine exerts cellular growth inhibition, pro-apoptotic and pro-autophagic effect via activating AMPK in MG-63 cells. Furthermore, chamaejasmine significantly increases autophagic cell via the inhibition of mammalian target of rapamycin (mTOR) and activation of AMPK signaling pathways. Administrated with chamaejasmine also induces reactive oxygen species (ROS) generation, indicating cross-talking between these two primary modes of programmed cell death.
Conclusion: Our results show that chamaejasmine promotes apoptosis and autophagy by activating AMPK/mTOR signaling pathways with involvement of ROS in MG-63 cells. Chamaejasmine is a promising anti-cancer agent in OS treatment, and further studies are needed to confirm its efficacy and safety in vivo or other cancer cells.
Post-conjunction detection of β Pictoris b with VLT/SPHERE
Authors: Lagrange A.-M. , Boccaletti A. , Langlois M. , Chauvin G. , Gratton R. , Beust H. , Desidera S. , Milli J. , Bonnefoy M. , Cheetham A. , Feldt M. , Meyer M. , Vigan A. , Biller B. , Bonavita M. , Baudino J.-L. , Cantalloube F. , Cudel M. , Daemgen S. , Delorme P. , D’Orazi V. , Girard J. , Fontanive C. , Hagelberg J. , Janson M. , Keppler M. , Koypitova T. , Galicher R. , Lannier J. , Le Coroller H. , Ligi R. , Maire A.-L. , Mesa D. , Messina S. , Müeller A. , Peretti S. , Perrot C. , Rouan D. , Salter G. , Samland M. , Schmidt T. , Sissa E. , Zurlo A. , Beuzit J.-L. , Mouillet D. , Dominik C. , Henning T. , Lagadec E. , Ménard F. , Schmid H.-M. , Turatto M. , Udry S. , Bohn A. J. , Charnay B. , Gomez Gonzales C. A. , Gry C. , Kenworthy M. , Kral Q. , Mordasini C. , Moutou C. , van der Plas G. , Schlieder J. E. , Abe L. , Antichi J. , Baruffolo A. , Baudoz P. , Baudrand J. , Blanchard P. , Bazzon A. , Buey T. , Carbillet M. , Carle M. , Charton J. , Cascone E. , Claudi R. , Costille A. , Deboulbe A. , De Caprio V. , Dohlen K. , Fantinel D. , Feautrier P. , Fusco T. , Gigan P. , Giro E. , Gisler D. , Gluck L. , Hubin N. , Hugot E. , Jaquet M. , Kasper M. , Madec F. , Magnard Y. , Martinez P. , Maurel D. , Le Mignant D. , Möller-Nilsson O. , Llored M. , Moulin T. , Origné A. , Pavlov A. , Perret D. , Petit C. , Pragt J. , Szulagyi J. , Wildi F. 
Published: November 2018

Context. With an orbital distance comparable to that of Saturn in the solar system, β Pictoris b is the closest (semi-major axis ≃9 au) exoplanet that has been imaged to orbit a star. Thus it offers unique opportunities for detailed studies of its orbital, physical, and atmospheric properties, and of disk-planet interactions. With the exception of the discovery observations in 2003 with NaCo at the Very Large Telescope (VLT), all following astrometric measurements relative to β Pictoris have been obtained in the southwestern part of the orbit, which severely limits the determination of the planet’s orbital parameters.
Aims. We aimed at further constraining β Pictoris b orbital properties using more data, and, in particular, data taken in the northeastern part of the orbit.
Methods. We used SPHERE at the VLT to precisely monitor the orbital motion of beta β Pictoris b since first light of the instrument in 2014.
Results. We were able to monitor the planet until November 2016, when its angular separation became too small (125 mas, i.e., 1.6 au) and prevented further detection. We redetected β Pictoris b on the northeast side of the disk at a separation of 139 mas and a PA of 30° in September 2018. The planetary orbit is now well constrained. With a semi-major axis (sma) of a = 9.0 ± 0.5 au (1σ), it definitely excludes previously reported possible long orbital periods, and excludes β Pictoris b as the origin of photometric variations that took place in 1981. We also refine the eccentricity and inclination of the planet. From an instrumental point of view, these data demonstrate that it is possible to detect, if they exist, young massive Jupiters that orbit at less than 2 au from a star that is 20 pc away.
Colorectal cancer stage at diagnosis in migrants and non-migrants: a cross-sectional analysis of the KoMigra Study in Germany
Authors: Dahlhaus Anne , Siebenhofer Andrea , Guethlin Corina , Taubenroth Maja , Albay Zeycan , Schulz-Rothe Sylvia , Singer Susanne , Plath Jasper 
Published: November 2018

Abstract
Background Colorectal cancer is one leading cause of cancer-related morbidity and mortality. Its prognosis depends largely on tumour stage at diagnosis. Migration status was associated with late stage at diagnosis in some studies, yet results are inconsistent.
Methods The cross-sectional study “The Diagnostics of Colorectal Carcinoma in Migrants and Non-Migrants in Germany” (KoMigra) investigated the association between migration background and tumour stage of colorectal cancer at diagnosis in a large German urban area. Patient variables were collected via a survey translated into nine languages. Data on tumour stage were extracted from medical records.
Results 437 patients could be recruited for analysis. Explorative logistic regression yielded no significant difference for tumour stage “I” versus “II-IV” according to the tumour classification “Union Internationale Contre le Cancer” (UICC) between migrants and non-migrants. Although the odds of a higher tumour stage were consistently higher in migrants than non-migrants, the effect estimates had wide confidence intervals. In descriptive analyses, migrants reported symptoms more often and for longer time than non-migrants. This was especially true for patients with poor proficiency of German.
Conclusions Migration background was not significantly associated with advanced tumour stage at diagnosis. However, the effect of poor language proficiency should be explored further.
MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation
Authors: Zhu Bing-Lin , Long Yan , Luo Wei , Yan Zhen , Lai Yu-Jie , Zhao Li-Ge , Zhou Wei-Hui , Wang Yan-Jiang , Shen Lin-Lin , Liu Lu , Deng Xiao-Juan , Wang Xue-Feng , Sun Fei , Chen Guo-Jun 
Published: November 2018

AbstractMMP13 (matrix metallopeptidase 13) plays a key role in bone metabolism and cancer development, but has no known functions in Alzheimer’s disease. In this study, we used high-throughput small molecule screening in SH-SY5Y cells that stably expressed a luciferase reporter gene driven by the BACE1 (β-site amyloid precursor protein cleaving enzyme 1) promoter, which included a portion of the 5′ untranslated region (5′UTR). We identified that CL82198, a selective inhibitor of MMP13, decreased BACE1 protein levels in cultured neuronal cells. This effect was dependent on PI3K (phosphatidylinositide 3-kinase) signalling, and was unrelated to BACE1 gene transcription and protein degradation. Further, we found that eukaryotic translation initiation factor 4B (eIF4B) played a key role, as the mutation of eIF4B at serine 422 (S422R) or deletion of the BACE1 5′UTR attenuated MMP13-mediated BACE1 regulation. In APPswe/PS1E9 mice, an animal model of Alzheimer’s disease, hippocampal Mmp13 knockdown or intraperitoneal CL82198 administration reduced BACE1 protein levels and the related amyloid-β precursor protein processing, amyloid-β load and eIF4B phosphorylation, whereas spatial and associative learning and memory performances were improved. Collectively, MMP13 inhibition/CL82198 treatment exhibited therapeutic potential for Alzheimer’s disease, via the translational regulation of BACE1.
A Novel Collaborate Neural Dynamic System Model for Solving a Class of Min–Max Optimization Problems with an Application in Portfolio Management
Authors: Nazemi Alireza , Mortezaee Marziyeh 
Published: November 2018

AbstractIn this paper, we describe a new neural network model for solving a class of non-smooth optimization problems with min–max objective function. The basic idea is to replace the min–max function by a smooth one using an entropy function. With this smoothing technique, the non-smooth problem is converted into an equivalent differentiable convex programming problem. A neural network model is then constructed based on Karush–Kuhn–Tucker optimality conditions. It is investigated that the proposed neural network is stable in the sense of Lyapunov and can converge to an exact optimal solution of the original problem. As an application in economics, we use the proposed scheme to a min–max portfolio optimization problems. The effectiveness of the method is demonstrated by several numerical simulations.
Twitter Analysis for Intelligent Transportation
Authors: Alhumoud Sarah 
Published: November 2018

Abstract
The amount of data available online has grown enormously over the last decade as a result of the rapid growth of smartphone users and the availability of communication applications. Due to the anonymity and instantaneous nature of social media broadcasting compared to conventional attitudinal survey methods, social media mining is becoming popular for complementing traditional traffic detection methods due to its accessibility in reaching a large population and the opportunities for reflecting the true and immediate behaviour of participants for free. This study presents a framework for Arabic Twitter content analysis to gain transportation insight. The study is done with a dataset of more than 1 million tweets collected within 3 months. The proposed model comprises three main components: data acquisition, data analysis and the reverse geotagging scheme (RGS). The RGS tackles the problem of lack of location information in the tweets. Results show that 13% of the dataset reports traffic-related incidents with an overall precision of 55% and 87% for incidents identification prediction without and with reverse geotagging, respectively. This proves the efficiency of the developed analyser in identifying tweets on transportation and the potential of the RGS in defining the location of tweets with no registered location information.