bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gluon to $$ \textrm{q}\overline{\textrm{q}} $$ antenna in anisotropic QCD matter: spin-polarized and azimuthal jet observables
Authors: Barata João , Salgado Carlos A. , Silva João M. 
Published: December 2024

Abstract
We study the production of a quark-antiquark antenna in the presence of a dense and anisotropic QCD medium. We assume the antenna to originate from an unpolarized gluon state, and consider both massless and massive final states. The medium anisotropy is captured by allowing the jet quenching coefficient to take different magnitudes in orthogonal directions with respect to the jet axis. We find that the final particle distribution is sensitive to the medium anisotropy, and more importantly, that this effect couples directly to the helicity/spin of the final states. We propose to look into these effects by performing a Fourier decomposition of the particle distribution inside the jet. In our medium model, we find that the spin independent terms contribute to the even harmonics of the cosine series. The helicity/spin dependence enters only through the sine Fourier series. We further explore the spin dependence by examining the degree of polarization of the final states in different directions. Our results indicate that the anisotropies present in the QCD matter produced in heavy ion collisions can be probed by studying azimuthal and spin observables inside jets.
Comparative effectiveness of kilo- and megavoltage energies in low-dose radiotherapy for painful degenerative musculoskeletal diseases: a systematic review and meta-analysis
Authors: Kim Aram , Kwon Jeanny , Kim Ji Young , Kim Byoung Hyuck 
Published: December 2024

Abstract
Purpose
This study aimed to assess the impact of different energy levels on the effectiveness of low-dose radiotherapy (LDRT) for treating painful degenerative musculoskeletal diseases, as comparative efficacy data are currently lacking.

Methods
A systematic review was conducted in PubMed, Embase, and the Cochrane Library databases to identify studies with response information on the energy used (kilovoltage [kV] vs. megavoltage [MV]). The primary endpoint was the overall response rate (ORR), and the secondary endpoint was the complete response rate (CRR). Exploratory subgroup analyses included treatment site, study period, study design, country, and dose per fraction.

Results
A total of 33 studies involving 12,143 patients were analyzed. Short-term follow-up (up to 6 months) showed a pooled ORR of 64% (95% CI 46–78%) for kV and of 62% (95% CI 54–70%) for MV. Long-term follow-up (at least 12 months) revealed a pooled ORR of 85% (95% CI 65–95%) for kV and of 69% (95% CI 62–75%) for MV. Subgroup analysis indicated no significant differences in ORR for energy level stratified by treatment site and other factors. Regarding dose per fraction (0.5 Gy vs. 1.0 Gy), comparable ORRs were demonstrated between the two energies. No clinical side effects were noted.

Conclusion
This meta-analysis suggests that the known effectiveness of LDRT in painful degenerative musculoskeletal disease may not depend on the energy used. Additional studies using standardized evaluation methods are warranted to establish consistency and enhance the comprehensiveness of research. Further research is also needed to explore treatment modality selection considering disease-specific biology.
Does a carboxamide moiety alter the toxicokinetics of synthetic cannabinoids? A study after pulmonary and intravenous administration of cumyl-5F-P7AICA to pigs
Authors: Walle Nadja , Dings Christiane , Zaher Omar , Doerr Adrian A. , Peters Benjamin , Laschke Matthias W. , Lehr Thorsten , Menger Michael D. , Schmidt Peter H. , Meyer Markus R. , Schaefer Nadine 
Published: December 2024

Abstract
Synthetic cannabinoids (SCs) are consumed as an alternative to cannabis. Novel compounds are developed by minor modifications in their chemical structure, e.g. insertion of a carboxamide moiety as a linker, which can potentially lead to altered toxicokinetics (TK). Knowledge on the TK data of SCs, especially structural modified substances, is scarce. Hence, interpretation of toxicological results is challenging. Therefore, the aim of the present study was to evaluate the TK of cumyl-5F-P7AICA in a pig model, which was shown to be suitable for TK studies of SCs. A 200 µg/kg body weight dose of cumyl-5F-P7AICA was administered intravenously (n = 6) or inhalatively (n = 10) via an ultrasonic nebulizer to pigs. Blood specimens were repeatedly drawn over 6 h and the concentrations of cumyl-5F-P7AICA as well as its N-pentanoic acid (NPA) metabolite were determined using a fully validated LC–MS/MS method. Based on the concentration–time profiles, a population TK analysis yielded a three-compartment model for the TK of cumyl-5F-P7AICA, whilst a two-compartment model described the NPA best. The incorporation of transit compartments accounts for the time delay between the appearance of cumyl-5F-P7AICA and NPA in serum. Finally, the model was upscaled to humans using allometric scaling. In comparison to older SCs, a higher volume of distribution was determined for cumyl-5F-P7AICA. No further relevant differences of the TK properties were observed. Insertion of a carboxamide moiety into the chemical structure of SCs does not appear to have only minor influence on the TK.
The vanishing limit of a rigid body in three-dimensional viscous incompressible fluid
Authors: He Jiao , Su Pei 
Published: December 2024

AbstractWe consider the evolution of a small rigid body in an incompressible viscous fluid filling the whole space $${{\mathbb {R}}}^3$$

R

3

. When the small rigid body shrinks to a “massless” point in the sense that its density is constant, we prove that the solution of the fluid-rigid body system converges to a solution of the Navier–Stokes equations in the full space. Based on some $$L^p-L^q$$

L
p

-

L
q

estimates of the fluid–structure semigroup and a fixed point argument, we obtain a uniform estimate of velocity of the rigid body. This allows us to construct admissible test functions which plays a key role in the procedure of passing to the limit.
Practical considerations in the establishment of psychedelic research programs
Authors: Barnett Brian S. , Vest M. Frances , Delatte Marcus S. , King IV Franklin , Mauney Erin E. , Coulson Anthony J. , Nayak Sandeep M. , Hendricks Peter S. , Greer George R. , Murnane Kevin S. 
Published: December 2024

Abstract

Rationale
There is increasing interest in establishing psychedelic research programs at academic medical centers. However, psychedelics are intensely psychoactive, carry considerable sociopolitical baggage, and most are Schedule I drugs, creating significant potential impediments to implementation. There is little formal guidance for investigators on navigating the complex on-the-ground obstacles associated with establishing psychedelic research programs.

Objectives
This article provides recommendations that may be helpful to investigators seeking to work with psychedelics, with a focus on academic medical centers in the United States.

Methods
The academic literature on relevant matters is reviewed, and the authors provide observations from their experiences either working for relevant regulatory agencies or conducting basic science studies, investigator-initiated trials, or industry sponsored trials with psychedelics.

Results
Investigators planning to conduct psychedelic research should cultivate broad institutional support early. Challenges related to securing funding, obtaining approval for an Investigational New Drug application from the Food and Drug Administration, clinical grade drug sourcing, obtaining a Schedule I researcher registration from the Drug Enforcement Administration and an equivalent state license (if required), preparing spaces for treatment and study drug storage, managing controlled substance inventory, engaging the local community, and other issues should be anticipated.

Conclusions
Investigators should anticipate several implementation challenges when planning to work with psychedelics. However, these are likely surmountable with planning, persistence, and assistance from colleagues and other experts.
Lionfish (Pterois volitans) do not show directional preferences for ambient underwater soundscapes during diurnal hours
Authors: Holmes Roxanne B , Hamilton Nadia M. , Simpson Stephen D. , Herbert-Read James E. 
Published: December 2024

AbstractSound is a valuable cue in the marine environment that can inform animals about habitat location and community composition. Indeed, sound is often used for orientation and navigation by larval reef fishes during settlement. However, despite sound’s role in the early life of reef fishes, whether post-settlement reef fishes use ambient soundscapes to inform their movement decisions remains less clear. In an in-situ playback experiment in Curaçao, the Dutch Caribbean, settled individuals of an invasive predator, the Indo-Pacific lionfish (Pterois volitans), showed no preference to move towards the playbacks of two different habitat types during daylight hours. In particular, lionfish did not prefer to move towards the sounds of sandy or reef habitat playbacks when tested against a silent control. Moreover, when given a choice between simultaneous sandy and reef habitat playbacks, lionfish showed no preference for the soundscape of either habitat type. While the activity of lionfish was strongly correlated with their body size, with larger fish being more active, activity was not affected by habitat playback, nor did body size affect their preference for the soundscapes of either habitat type. While acoustic lures have been speculated to be a promising addition to existing lionfish trap designs, daytime playbacks of ambient soundscapes are unlikely to be successful in attracting lionfish post-settlement, ultimately affecting their efficacy.
A new modeling approach for denitrification taking internal chemical gradients into account
Authors: Schulze Johannes , Zawallich Jan , Ippisch Olaf 
Published: December 2024

AbstractIn this paper a new modeling approach for denitrification and similar processes, which depend on the geochemical gradient between the air-filled larger pores in a soil and a water-filled matrix, is presented. The new modeling approach is capable of taking soil structural properties (obtained e.g. from X-ray CT) into account without requiring a high-resolution simulation. The model approach is explained and its application is demonstrated by simulating denitrification experiments conducted with repacked soil samples to assess the challenges and possibilities of the new approach. The main result of the modeling is that the nitrous oxide emission measured in the experiment can not be explained by a limited supply with oxygen alone at a carbon turnover rate derived from carbon dioxide emissions. It is additionally necessary that the microbial activity is concentrated in localized hot spots to create anaerobic conditions. This is confirmed by analytical solutions.
Occupational psychosocial stressors and ergonomic strain during pregnancy and sex-specific risk of childhood asthma
Authors: Dornfeldt Mette Møller , Tøttenborg Sandra Søgaard , Flachs Esben Meulengracht , Begtrup Luise Mølenberg , Madsen Ida Elisabeth Huitfeldt , Hougaard Karin Sørig , Sejbaek Camilla Sandal 
Published: December 2024

Abstract

Objectives
Previous studies have indicated that maternal occupational psychosocial stressors may affect the risk of asthma in the offspring, but their results are inconsistent. Maternal occupational ergonomic strain is associated with predictors of fetal lung development, including preterm birth and low birthweight; however, it is not known, whether ergonomic strain during pregnancy is a risk factor for asthma in offspring. The aim was to investigate maternal psychosocial stressors and ergonomic strain during pregnancy relative to the risk of offspring asthma.

Methods
Live- and firstborn singletons (1996–2018) and their mothers were identified from Danish nationwide registers. Job code at time of conception was assigned to each mother and linked with exposure estimates from job exposure matrices (JEMs) of psychosocial stressors and ergonomic strain. Diagnoses of childhood asthma were retrieved from the Danish National Patient Register. Incidence rate ratios (IRR) of asthma were estimated using Poisson regression; adjusted for maternal asthma, age at conception, socioeconomic position, and body mass index, and calendar year.

Results
Maternal employment in occupations with low decision authority (IRR: 1.08, 95% CI 1.00–1.16) and high ergonomic strain (IRR: 1.09, 95% CI 1.02–1.16) was associated with increased risk of asthma among male offspring. Largely similar, but less consistent, associations were observed among female offspring due to low decision authority.

Conclusion
We found a minor increased risk of asthma among offspring whose mothers worked in an occupation with low decision authority or high ergonomic strain, most pronounced among male offspring.
Uterine sarcoma with KAT6B/A::KANSL1 fusion: a molecular and clinicopathological study on 9 cases
Authors: Dundr Pavel , Dvořák Jiří , Krausová Michaela , Hojný Jan , Hájková Nikola , Stružinská Ivana , Němejcová Kristýna , Ondič Ondřej , Michal Michael , Michalová Květoslava , Berjón Alberto , Jedryka Marcin , Książek Mariusz , Poprawski Tymoteusz , Ryś Janusz , Volodko Nataliya , Zapardiel Ignacio , Zima Tomáš , Cibula David , Poncová Renata , Matěj Radoslav , Kendall Bártů Michaela 
Published: December 2024

AbstractUterine sarcomas with KAT6B/A::KANSL1 fusion represent a new entity characterized by bland morphology, commonly with hybrid features of low-grade endometrial stromal sarcoma (LG-ESS) and tumors with smooth muscle differentiation. In our study, we performed a detailed morphological, immunohistochemical, and molecular analysis of 9 cases of these tumors. Six of those had been originally diagnosed as LG-ESS, one as leiomyoma, one as leiomyosarcoma, and the remaining case as sarcoma with the KAT6B/A::KANSL1 fusion. Seven cases showed overlapping features between endometrial stromal and smooth muscle tumors, one case resembled cellular leiomyoma, and one case resembled high-grade endometrial stromal sarcoma. Immunohistochemically, the tumors showed a common expression of smooth muscle markers and endometrial stromal markers. Molecular findings showed the KAT6B/A::KANSL1 fusion in all cases (by NGS and FISH). In addition, mutations affecting genes such as TP53, PDGFRB, NF1, RB1, PTEN, ATM, RB1, FANCD2, and TSC1 were present in all 5 cases with aggressive behavior. One patient with no evidence of disease showed no additional mutations, while another harbored a mutation of a single gene (ERCC3). Of the 8 patients with available follow-up, two died of disease, 3 are currently alive with disease, and 3 have no evidence of disease. The correct recognition of tumors with the KAT6B/A::KANSL1 fusion is essential because despite the bland morphological features of most cases, these tumors have a propensity for aggressive behavior.
Preferences of melanoma patients to accept adjuvant therapy and toxicity – a qualitative substudy of the GerMelaTox-A project
Authors: Janke Toni Maria , Moysig Laura , Blome Christine , Kähler Katharina C. 
Published: December 2024

Abstract

Purpose
Targeted treatment and immunotherapy, both adjuvant treatment options, come with a certain toxicity and can cause severe side effects. To date, data about the underlying reasons for patients to accept or reject specific types of adjuvant therapy is scarce. Therefore, this study investigates the motives of melanoma patients for tolerating or rejecting adjuvant therapy and its side effects.

Methods
We conducted semi-structured interviews with a subsample of patients to investigate the underlying reasons for treatment decisions in a quantitative treatment-trade off study. Categorisation was conducted using qualitative content analysis.

Results
The 17 participants had a mean age of 55.5 years and 12 were female. The final category system covered three clusters. The cluster “type of therapy and therapy process” described therapy-related aspects that affect acceptability of adjuvant treatments. Prospect of treatment benefit and side effects were important aspects. Route of administration and physician visits should be convenient. The cluster “way of living” described the influence that activities and circumstances of life organisation have on acceptability. Participants wished treatment to affect everyday life as little as possible. Maintaining sufficient quality of life was mentioned to be crucial. The cluster “emotions and feelings” described optimism and hope but also mental strain originating from possible treatment options.

Conclusion
Patients in our study indicate high willingness to undergo adjuvant therapy, even when facing toxicity. The evaluation of potential side effects and prospects of treatment benefit is highly individual. Therefore, it is important to consider personal patient preferences to make appropriate and shared decision-making.
Phase transition in porous materials: effects of material parameters and deformation regime on mass conservativity
Authors: Brodbeck Maximilian , Suditsch Marlon , Seyedpour Seyed Morteza , Ricken Tim 
Published: December 2024

AbstractPhase transition in porous materials is relevant within different engineering applications, such as freezing in saturated soil or pancake sea ice. Mathematical descriptions of such processes can be derived based on Biot’s consolidation theory or the Theory of Porous Media. Depending on parameters such as density ratio, permeability or compressibility of the solid matrix, either small or finite deformations occur. Numerical solution procedures for the general, finite deformation case, suffers from instabilities and high computational costs. Simplifications, assuming small deformations, increases stability and computational efficiency. Within this work shortcomings of simplified theories based on Biot and linearisations of the Theory of Porous Media (TPM) are systematically studied. In order to determine the interaction of the different model parameters a non-dimensional model for poro-elasticity is presented. Based on a characteristic test-case including phase-transition and consolidation, the simplified models are compared to the fully non-linear TPM, focusing on mass errors as well as the time behaviour of the solution. Taking further into account the efficiency of discretisation based on different primal variables and finite-element-spaces, a guideline for selecting an appropriate combination of model, kinematic assumption and discretisation scheme is presented.
Hyper-personalized employment in urban hubs: multimodal fusion architectures for personality-based job matching
Authors: Jain Dipika , Sangwan Saurabh Raj , Kumar Akshi 
Published: December 2024

AbstractIn the evolving landscape of smart cities, employment strategies have been steering towards a more personalized approach, aiming to enhance job satisfaction and boost economic efficiency. This paper explores an advanced solution by integrating multimodal deep learning to create a hyper-personalized job matching system based on individual personality traits. We employed the First Impressions V2 dataset, a comprehensive collection encompassing various data modalities suitable for extracting personality insights. Among various architectures tested, the fusion of XceptionResNet with BERT emerged as the most promising, delivering unparalleled results. The combined model achieved an accuracy of 92.12%, an R2 score of 54.49%, a mean squared error of 0.0098, and a root mean squared error of 0.0992. These empirical findings demonstrate the effectiveness of the XceptionResNet + BERT in mapping personality traits, paving the way for an innovative, and efficient approach to job matching in urban environments. This work has the potential to revolutionize recruitment strategies in smart cities, ensuring placements that are not only skill-aligned but also personality-congruent, optimizing both individual satisfaction and organizational productivity. A set of theoretical case studies in technology, banking, healthcare, and retail sectors within smart cities illustrate how the model could optimize both individual satisfaction and organizational productivity.
Swallowing function in patients with spinal muscular atrophy before and after the introduction of new gene-based therapies: what has changed?
Authors: Ruggiero Marta , Giannotta Gabriele , Pirani Greta , Saponaro Federica , Oliva Maria Carmela , Ferrante Camilla , Trabacca Antonio 
Published: December 2024

Abstract

objective
Individuals diagnosed with Spinal Muscular Atrophy (SMA), particularly those presenting with the most severe phenotypes, have long contended with significant swallowing dysfunction. The recent emergence of efficacious advanced therapy has fundamentally altered the landscape of SMA management. By encompassing both the pre and post gene-based therapy eras within our analysis, we endeavour to elucidate the potential impact of these novel therapeutic interventions on this function.

Methods
Following the established methodology outlined by the Joanna Briggs Institute, a scoping review was conducted. This review encompassed relevant literature published up to March 2024. Two electronic databases were searched, with additional studies identified by reviewing reference lists of pertinent articles. The search strategy employed a combination of keywords including “spinal muscular atrophy”, “SMA”, “swallowing”, “feeding”, and “nutrition”. Articles were initially screened based on title and abstract, followed by a full-text review of eligible studies published in peer-reviewed English language journals.

Results
The initial database search resulted in 462 articles, from which 23 studies were ultimately selected for analysis. Pre gene-based therapy studies revealed swallowing dysfunction as a prominent feature. Patients frequently reported challenges with chewing, choking on solids and liquids, and abnormal tongue movements during eating. Early dysphagia research relied on subjective measures (questionnaires, scales). objective measures like video fluoroscopic (VFSS) were rare. After gene-based therapies (GBTs), VFSS became the dominant, more objective method. Studies investigating the post-gene therapy era suggest potential clinical benefits, with trends towards improvement or stabilization of swallowing function.

Conclusion
Pre gene-based therapy studies revealed widespread swallowing dysfunction in SMA. Conversely, the post-treatment era suggests potential improvement. Future research should prioritize identifying optimal therapies for individual swallowing function and develop validated assessments to optimize SMA management.
Evaluating Liturgical Engagement With Psalms of Lament: Reading Psalm 74 Through the Lenses of Feeling and Thinking
Authors: Francis Leslie J. , Holdsworth John , Village Andrew 
Published: December 2024

AbstractRecent trends in biblical scholarship that have generated new interest in the book of Psalms and in the voice of lamentation may in turn present new opportunities for the liturgical use of psalms of lament. Drawing on the SIFT approach to biblical hermeneutics, the present study tested the ways in which feeling types and thinking types may evaluate Psalm 74 differently. The data demonstrated that feeling types and thinking types approach a psalm of lament in quite different ways. For thinking types, this is a satisfying intellectual exercise. They are caught up by the theological questions raised and fascinated by the capacity of the human mind to challenge God to keep God’s side of the covenantal agreement with the people. For feeling types, this is a journey of the heart as they identify with the protagonists rehearsing the source and cause of their pain. Preachers and liturgists need to be aware of this contrast.