bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gynecological malignancies in pediatric and adolescent group: a ten year experience in a national cancer center of Nepal
Authors: Sharma KS , Pariyar J , Misra D , Mehta S , Panthee S 
Published: September 2019

Introduction: Gynecological malignancies in pediatric and adolescent group are common. Germ cell tumors and gestational trophoblastic neoplasia are the most frequently found malignancies which are highly chemosensitive. With prompt and appropriate treatment higher cure rate is attainable in such malignancies even in resource constraints country like Nepal.
Objective: To study the clinicopathological profile and treatment outcome of gynecological malignancies among pediatric and adolescent group seeking treatment at B.P. Koirala Memorial Cancer Hospital (BPKMCH), Nepal.
Methodology: Descriptive study was done at BPKMCH Nepal. All available case records of pediatric and adolescent girls diagnosed to have gynecological malignancies from 2002 to 2011 were collected and analyzed in terms of age, clinical features, malignancy types, treatment modalities and outcome.
Results: Total 60 girls were eligible for the study. There were five patients (8.3%) below five years, 14 (23.3%) between 6-12 years and 41 (68.4%) patients between 13-19 years. Gynecological malignancies observed among the study group were: ovarian cancer in 46 (76.66%), gestational trophoblastic disease in 11 (18.33%), uterine cancer in two (3.33%) and vaginal cancer in one (1.66%). Among the ovarian cancers, 42 had malignant germ cell cancer (91.3%), three had epithelial ovarian cancer (6.5%) and one had juvenile granulose cell tumor. The commonest presentation was abdominal distension and pain in 70%. Onset of symptoms ranged from three days to 730 days (mean 95 days). Early stage disease was noted in 18 (30%) and advanced disease in 42 (70%). Eight (13.33%) underwent fertility sparing surgery only, 21(35%) underwent chemotherapy only and 31(51.66%) underwent multimodality treatment. Twenty (33.33%) defaulted and 40 (66.66%) completed treatment among which progressive disease and mortality was recorded in seven (17.5%) patients and 33 (82.5%) attended cure.
Conclusion: Malignant germ cell cancer is the commonest gynecologic malignancy among pediatric and adolescent girls. In country where childhood marriage is still prevalent, GTT is also more common among adolescent girls. Early presentation and prompt appropriate treatment would offer chances of cure even with preservation of fertility.
औपन्यासिक तत्वका आधारमा ‘एक चिहान’ उपन्यासको विश्लेषण Aaupanyasik Tatwaka Aadharma 'Ek Chihan' Upanyasko Vishleshan
Authors: विष्ट Bista सीताराम Sitaram राज Raj 
Published: September 2019

Not available.
उपलब्ध छैन .
Pra-Rancangan Instalasi Pengolahan Air Limbah (Ipal) Industri Batik (Studi Kasus Batik Sembung, Sembungan Rt.31/Rw.14, Gulurejo, Lendah, Kulonprogo)
Authors: Hastutiningrum Sri , Purnawan Purnawan 
Published: September 2019

Perancangan ini bertujuan untuk memberikan rancangan pengolahan limbah cair batik bagi industri batik di Yogyakarta. Beberapa parameter limbah cair batik sebelum diolah masih melebihi baku mutu, yaitu : TDS 5.325 mg/l, BOD 2.712,02 mg/l, COD 10.464,00 mg/l, dan pH 10,5. IPAL dirancang secara batch dengan sistem ekualisasi, koagulasi-flokulasi, sedimentasi, kontrol, dan pengering lumpur. Tahap perancangan IPAL meliputi menghitung ukuran dimensi masing-masing unit IPAL, merancang gambar masing-masing unit, dan menghitung rencana anggaran biaya yang diperlukan. Terdapat beberapa unit pada perancangan IPAL, salah satunya limbah cair batik sebanyak 5,5 m3 beserta dimensi yaitu : bak ekualisasi (panjang = 2,2m, lebar = 1,1m, tinggi = 2,5m), bak koagulasi-flokulasi (diameter = 1,2m, tinggi = 1,95m), bak sedimentasi (panjang = 2,013m, lebar = 1,0065m, tinggi = 1m), bak pengering lumpur (panjang = 0,92m, lebar = 0,46m, tinggi = 0,77m), bak filtrasi (panjang = 2,36m, lebar = 1,18m, tinggi = 2,4m), dan bak kontrol (panjang = 1,138m, lebar = 1,138m, tinggi = 1,138m). Adapun total rencana anggaran biaya yang dibutuhkan dalam perancangan IPAL limbah cair industri batik adalah sebesar Rp 67.833.300,34.
Amino acids composition of herb of Lamiaceae family representatives
Authors: Shanayda M. I. 
Published: September 2019

Researching of the amino acids contents in medicinal plant raw materials is an important task of pharmaceutical science and practice, because complexes of amino acids used for the corrections of hepatobiliary disorders, nervous and cardiovascular systems.
The aim of this study was to conduct a qualitative and quantitative analysis of amіno acids composition of these representatives.
The article presents the results of the amino acid composition investigation of the above-ground parts of 10 species belonging to Lamiaceae Juss. Family (Ocimum, Hyssopus, Dracocephalum, Lophanthus, Monarda and Satureja genera). By paper chromatography it was identified several amino acids. HPLC analyzes revealed the content and composition of more than 20 amino acids. The highest total amino acid composition was found in the herb of the genus Ocimum. It was identified 10 essential and non-essential 9 amino acids in each herb, and 3 nonproteinogenic amino acids also. It was established that in all plant materials dominate quantitatively nonessential amino acids (asparagine, proline, glutamic and aspartic acid). Among the essential amino acids arginine and threonine predominate.
Development and validation of the methods of phenytoin determination in urine by the method of gas–liquid chromatography
Authors: Klimenko L. Yu. , Bondar V. S. , Gumeniuk O. V. 
Published: September 2019

Development of the methods of strong medicines determination in human biological liquids for application in forensic and clinical toxicology is one of actual problems of pharmaceutical science, but validation of the analytical methods becomes much more vital and widely discussed problem in analytical toxicology in the last decade.
The purpose of the paper was to develop the methods of phenytoin quantitative determination in urine based on the offered before procedure of the analyte determination by the method of gas–liquid chromatography and to carry out validation of the developed methods in the variant of the method of calibration curve according to the approaches offered by authors for choosing the optimal procedure of phenytoin isolation from the mentioned biological matrix.
The set of GLC-methods of phenytoin quantitative determination in urine using different procedures of sample preparation – by extraction with chloroform in the acid medium and by maceration with acetonitrile without acidifying and at pH = 2 with subsequent separation of organic layer under the conditions of aqueous phase saturation by ammonium sulphate – has been developed.
Validation of the developed methods has been carried out and it has been set that acetonitrile application in the acid medium (рН = 2) is optimal for phenytoin determination in urine – extraction efficiency is maximal and equal to ~97%, and performance of linearity, accuracy and precision is optimal.
Application possibility of the offered approaches to validation of quantitative determination methods for forensic and toxicological analysis in the variant of the method of calibration curve for validation of procedure using the method of gas–liquid chromatography has been shown.
Antimicrobial and antifungal properties of 4-((R-iden)amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol
Authors: Safonov A. A. , Panasenko Т. V. , Knysh E. G. , Polishchuk N. M. 
Published: September 2019

For creating a new biologically active compounds are using a system on which already exist medications. One such system is the core of 1,2,4-triazole.
The aim of our work was to study the antimicrobial and antifungal activity new 4-((R-iden)amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiols. The study was conducted according to the method of serial dilutions.
As a result of studies new synthesized 4-((R-idene)amino)-5-(thiophene-2-ilmetyl)-4H-1,2,4-triazoles-3-thiols exhibit antimicrobial and antifungal activity.
The most active compound that exhibits antimicrobial activity against Staphylococcus aureus is 4-((1-(phenyl)ethylidene)amino)-5-(thiophene-2-ilmetyl)-4H-1,2,4-triazoles-3-thiol and 4-((3-nitrobenzylidene)amino)-5-(thiophene-2-ilmetyl)-4H-1,2,4-triazoles-3-thiol, 4-((4-fluorbenzylidene)amino)-5-(thiophene-2-ilmetyl)-4H-1,2,4-triazoles-3-thiol exhibit antifungal activity level of the comparator fluconazole, compound III, VI exceed its performance.
UV-spectrophotometric study of the 7-((3-thio-4-R-1,2,4-triazole-3-yl)methyl)-theophyllines
Authors: Gotsulya A. S. , Panasenko A. I. , Knysh E. G. , Pryimenko A. O. 
Published: September 2019

Chemistry of the 1,2,4-triazole derivatives recently attracts the attention of many scientists, mainly due to the presence of the number of the valuable pharmacological properties. In modern medical practice, there are many examples of successful heterocyclic systems derivatives usage. First of all, it is a group of drugs with antifungal activity (fluconazole, itraconazole, voriconazole, pozakonazol), antidepressant activity (alprazolam, triazolam), anticancer activity (anastrozole, letrozole). But despite the great practical importance of works in this area, the structure of 1,2,4-triazoles-3-thione derivatives have been studied imperfectly. Therefore, the study of this class of compounds is actual now.
The aim of this work was to study the UV-spectra of the research compounds in different polarity solvents (water, 95% ethanol, 0,1 M and 1 M sodium hydroxide, 0,1 M and 1 M hydrochloric acid, 0,1 M and 1 M sulfate acid solution, chloroform, isopropanol, acetonitrile and dioxane) for structure–spectral data relationship establishing.
Spectrophotometer SPECORD 200-222U214 was used to study the UV-spectra of the analyzed compounds and to measure their intensity.
During the research, it was found that the electronic spectra of 7-((3-thio-4-methyl-1,2,4-triazoles-5-yl)methyl)theophylline, 7-((3-thio-4-ethyl-1,2,4-triazolе-5-yl)methyl)theophylline and 7-((3-thio-4-phenyl-1,2,4-triazolе-5-yl)methyl)-theophylline were characterized by maximums in the short-wave (203–235 nm) and medium-wavе part (250–272 nm) of UV-spectrum.
Due to the presence of the methylene fragment in investigated molecules, which connects the purine cycle with 1,2,4-triazole, absorbtion maximums were caused by π→π*-electron jumping of the corresponding type 1La and 1Lb.
Determination of the glucose residues on pharmaceutical equipment surfaces by both methods: polarimetry and HPLC
Authors: Fedosenko A. А. , Scrypynets Yu. V. , Leonenko I. I. , Yegorova A. V. , Kashutskуy S. N. , Antonovich V. P. 
Published: September 2019

Cleaning of equipment in the production of medicines is an important requirement of good manufacturing practice (GMP). As a rule, the same process equipment is used for the production of a number of different drugs that may result in cross-contamination. In order to prevent the contamination there is need in efficient cleaning of equipment used with the validation methods for each part of equipment. There is need as well to prove and establish acceptable residual limits of active pharmaceutical ingredients (API) on the surface of the equipment after purification (purity acceptance criteria) based on the therapeutic dose of API, toxicity, volume of series, the surface area of the used equipment.
The aim of this work is the development of the simple and selective polarimetry and HPLC methods for determining residual amounts of glucose in washings from surfaces of pharmaceutical equipment after production of the drug. The object of the research is glucose, which is a part of the drug Regidron, powder for oral solution of 18.9 g per sachet. The swab Alpha® Sampling Swab TX715; membrane filters 0.20 µm; Minisart RC 15 «Sartorius» (Germany) were used. The polarimetric and HPLC methods for determination of glucose residues in washings from surfaces of pharmaceutical equipment after production the Regidron were developed.
The recovery rates of glucose from swabs and pharmaceutical equipment surfaces are more than 90%. The proposed simple and rapid methods are characterized by satisfactory metrological characteristics and can be recommended to determine the residues of glucose in controlling the quality of cleaning pharmaceutical equipment.
Using the thermal methods of analysis in selecting the optimal production techniques for tablets based on ademetionine 1,4-butanedisulfonate substance
Authors: Burdak K. S. , Yarnyh T. G. , Yanchuk I. B. , Borschevskiy G. I. 
Published: September 2019

When developing tablets on the base of ademetionine 1.4-butandionsulfonat substance it is difficult to obtain a stable product, as substance is hygroscopic, and its quantity in the tablet is 90% by weight of the core.
The aim of our work was the choice of conditions which would assure the safety of physical and chemical properties of the substance in the production process and allowed to get quality product.
Tablet mass was prepared by dry mixing, controlling the relative humidity in the range from 15 to 50% and a temperature from 15 to 25 °C. Studies were carried out by differential scanning calorimetry and the method for determining the weight of moisture. The results were compared with those obtained in studies for comparing drug Geptral (Abbott SpA, Italy).
As a result of studies was found that study samples number 1 and number 2 are as close as possible to their thermodynamic properties to the comparing drug. However, achieving a relative humidity of 15% is costly compared with values reaching 20%. Thus in the case of serial production is sufficient to create the following conditions: relative humidity not above 20%, the temperature +20,0 ± 2,0 °C.
Study of the acute toxicity of the praziquantel using different routs of administration
Authors: Kechin І. L. , Romanina D. M. , Gladishev V. V. , Dudun A. D. 
Published: September 2019

Patients with similar to acne dermatosis have more strongly pronounced clinical symptoms and significant increase of relapses rate in case of the demodicosis presence. Praziquantel is an antiparasitic substance with activity regarding to flukes and cestodes. Investigations carried out by the domestic scientists exposed also a presence of the antidemodicosic effect.
In Ukraine praziquantel is registered in the form of the oral tablets long using of which provokes gastrointestinal side effects. In view of this fact usage of alternative praziquantel routs of administration draws interest.
The aim of this work is study of the acute toxicity of the praziquantel using intraperitoneal, oral, rectal and topical administration.
Investigations of the toxicity were carried out according to the order of preclinical study and data examination of the preclinical study of drugs.
It was established that praziquantel intraperitoneal (LD50 = 564 mg/kg) and intragastric (LD50 = 1 030 mg/kg) administration in white rats by the extent of toxicity is a slightly dangerous substance (3 toxicity class). Study of the acute toxicity of the model semisolid application dosage forms in subtoxic dose for external administration showed that single applying of the external ointment and rectal suppository with this active substance in the maximum allowable volume doesn’t lead to the laboratory animal’s death and doesn’t negative influence on the examining parameters of their homeostasis. It is determined that praziquantel dosage forms for the external and rectal administration less toxic than oral tablets and are practically nontoxic substances.
Deteksi Gas Aseton sebagai Biomarker dalam Napas Manusia dengan Metode Spektroskopi Fotoakustik Laser
Authors: Yoga pratama Ananta Kusuma 
Published: September 2019

Abstrak: Dalam penelitian ini, telah dilakukan deteksi dan pengukuran konsentrasi gas aseton dalam gas hembus pernapasanmanusia menggunakan spektrometer fotoakustik sensitifitas tinggi. Laser CO2 kontinyu dengan panjang gelombang 9 sampaidengan 11mm sebagai sumber radiasi digunakan untuk medeteksi gas aseton. Pada penggunaannya, laser dikombinasikandengan teknik spektroskopi fotoakustik konfigurasi intrakavitas. Optimasi daya laser CO2 menghasilkan daya intrakavitasterukur 53 watt. Batas deteksi terendah (BDT) secara teoritisnya didapatkan sebesar 2,2 ± 0,04 ppb. Deteksi gas biomarkerpada gas hembus pernapasan manusia telah berhasil mengukur konsentrasi gas aseton sebesar 540±6 ppb.Kata kunci: gas aseton, spektroskopi fotoakustik, laserAbstract: In this study, the detection and measurement of acetone gas concentrations in human respiratory bladder gas usinga high sensitivity photoacoustic spectrometer was performed. The continuous CO2 lasers with wavelengths of 9 to 11 μm asradiation sources was used to detect acetone gas. In its applications, the continuous CO2 lasers was combined withphotoacoustic spectroscopy techniques of intracavity configuration. The optimization of CO2 laser power produces a measured53 watts intracavity power. The lowest detection limit (BDT) is theoretically obtained at 2.2 ± 0.04 ppb. Detection of biomarkergas in human respiratory human bladder gas has successfully measured the concentration of acetone gas by 540 ± 6 ppb.Keyword: acetone gas, photoacoustic spectroscopy, laser
Legal Framework for the Police Commissions: Current State and Prospects for Development
Authors: Sviatokum I. O. 
Published: September 2019

The article deals with the current legal framework for the activities of the police commissions in Ukraine. These bodies, established under the 2015 Law of Ukraine “On National Police”, are tasked primarily with ensuring transparent staffing of the police by conducting competitive selection of the candidates for the positions in the police. They include representatives from the Ministry of Internal Affairs, National Police as well as representatives of the civil society, appointed on the by the oblast councils on the local and by the Verkhovna Rada Human Rights Ombudsperson on the countrywide level. However, in the study, a number of problems of the existing regulations have been identified.
The first group concerns the way the commissions are established, namely, there is no single approach to the establishment of the commissions of the interregional territorial police forces (such as the Patrol Police). While some of these forces have only one police commission, functioning in Kyiv, the others (including the Patrol Police) have separate police commissions for every oblast. While the latter provides better representation of the local interests, legal status of such commissions requires clarification. Additionally, it was proposed, that establishment of the police commissions on the level below the oblasts seems to be appropriate in order to better represent interests of the communities.
The second problem stems from the fact that the contests involving police commissions are obligatory only for the first assignment in the police, while further career decisions are at the respective police director’s discretion. There are no criteria that make appointment through the procedures of the police commissions obligatory for any position in the police, which significantly lowers their relevance for the further career development of the police officers. Therefore, it was proposed to establish a list of the positions, for which the contest would be mandatory.
Finally, the article deals with the issue of the policing priorities. While they are mentioned in the Law of Ukraine “On National Police”, the powers of the police commissions to issue them are not sufficiently regulated. It was suggested, therefore, to establish a mechanism, under which the police commissions would draft policing priorities and the respective local councils would adopt them.
Issues of the Professional Development of Investigators of Pre-Trial Investigation Agencies of the National Police of Ukraine
Authors: Miloradova N. E. 
Published: September 2019

It has been noted that professional development of investigators of pre-trial investigation agencies of the National Police is a multi-faceted process, which includes both statutory regulated mandatory measures and appropriate professional and psychological support, as well as self-education and self-improvement of specialists. That is why consideration of the problems arising in the process of professional development and self-affirmation of employees of investigative units is a prerequisite for improving the efficiency of their activities. Legislative acts regulating the peculiarities of the professional development of investigators of the National Police of Ukraine have been considered.
Among the disadvantages of psychological support for passing consistent professional-genetic steps by investigators within the stage of professional development, the author has studied issues at the stages of professional adaptation (adaptant), mastering professional activity (intern), creative self-expression (master), mentoring (mentor), dismissal and social re-adaptation.
The author has analyzed the problems of advanced training of investigative units’ employees and the problems of professional training among the disadvantages of organizational and methodological support for the professional development of investigative units’ employees after the graduation from the professional training.
It has been also noted that the heads of structural units do not always let their subordinates to study at the correspondence course in institutions of higher education; investigators have lack of time for self-education, self-improvement and self-training for studies that reduces their motivation to self-improvement.
SISTEM PENDUKUNG KEPUTUSAN PEMILIHAN PENGGUNAAN JENIS TANAMAN DENGAN METODE ANALYTIC HIERARCHY PROCESS (AHP)
Authors: Mala Nur Musyarrofatul , Muhibuddin Anton , Sifaunajah Agus 
Published: September 2019

Agriculture is an important sector that can not be separated in determining the formation of various economic and social reality of society in various regions of Indonesia. Most of the livelihoods of the Indonesian community are covered by agriculture. In daily life for farmers there are still many problems or constraints such as crop failure due to less suitable land for plant growth, climate uncertainty and others. So in this case will be made information system that will provide recommendations for farmers in determining the use of plant species in accordance with the conditions of land in certain areas.This application use the Analytic Hierarchy Process (AHP) as a method that will take the decision of some criteria by calculating the weight ratio or value on each type of plant and will produce information in the form of cropratings are recommended. So that decision support system with AHP method can be used as one solution in solving the problem of choosing the use of plants in accordance with the condition of the land in certain areas.
Keywords: Analytic Hierarchy Process (AHP), Decision Support System, Land Suitability