bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain, antibiotics, and microbiota – how do they interplay?
Authors: Rybnikova Elena 
Published: June 2018

AbstractThe microbiome and its cross‐talk with the brain have drawn increasing attention lately, since imbalances in the gut microbiota's composition may result in pathogenic dysfunctions affecting brain functioning up to development of neurodegenerative and mental diseases. The current Editorial discusses a study by Gao and coworkers in the current issue of the Journal of Neurochemistry in which the authors use a model of antibiotic‐induced dysbiosis ‐ targeted infusion of antibiotics into the gut ‐ to assess if microbiotic metabolites exert effects on local neurotransmitter expression or contribute to the gut‐brain axis. The authors mechanistically link distal ileal infusion of antibiotics with a change in the levels of microbial metabolites that affect the expression of neurotransmitters in the brain and thereby can participate in the fine‐tuning of the hypothalamic functions, including regulation of visceral and neuroendocrine processes, stress responses, mood and anxiety. Their study thus represents an important step towards our understanding of the brain‐gut axis, with the potential to advance therapeutics.
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HCN channels in the hippocampus regulate active coping behavior
Authors: Fisher Daniel W. , Han Ye , Lyman Kyle A. , Heuermann Robert J. , Bean Linda A. , Ybarra Natividad , Foote Kendall M. , Dong Hongxin , Nicholson Daniel A. , Chetkovich Dane M. 
Published: June 2018

AbstractActive coping is an adaptive stress response that improves outcomes in medical and neuropsychiatric diseases. To date, most research into coping style has focused on neurotransmitter activity and little is known about the intrinsic excitability of neurons in the associated brain regions that facilitate coping. Previous studies have shown that HCN channels regulate neuronal excitability in pyramidal cells and that HCN channel current (Ih) in the CA1 area increases with chronic mild stress. Reduction of Ih in the CA1 area leads to antidepressant‐like behavior, and this region has been implicated in the regulation of coping style. We hypothesized that the antidepressant‐like behavior achieved with CA1 knockdown of Ih is accompanied by increases in active coping. In this report, we found that global loss of TRIP8b, a necessary subunit for proper HCN channel localization in pyramidal cells, led to active coping behavior in numerous assays specific to coping style. We next employed a viral strategy using a dominant negative TRIP8b isoform to alter coping behavior by reducing HCN channel expression. This approach led to a robust reduction in Ih in CA1 pyramidal neurons and an increase in active coping. Together, these results establish that changes in HCN channel function in CA1 influences coping style.
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The influence of iatrogenic interatrial septum leaks after left atrial appendage closure on cardiac function test results
Authors: Mitrega Katarzyna , Streb Witold , Szymala Magdalena , Podolecki Tomasz , Leopold‐Jadczyk Anna , Morawski Stanislaw , Kalarus Zbigniew 
Published: June 2018

AimLeft atrial appendage occlusion (LAAO) is a technique for preventing thromboembolism in patients with atrial fibrillation and a high risk of irreversible bleeding. In some patients, a spontaneous iatrogenic transseptal leak (ITL) remains after LAAO. The aim of this study was to assess the correlation between ITL incidence and the results of cardiac function tests in patients who underwent LAAO.Methods and ResultsLAOO was performed in 62 consecutive patients using the Amplatzer Amulet. Before and 3 months after LAA occlusion, the 6‐min walking distance (6MWD) test was performed in all patients and oxygen consumption assessment (VO2max) was performed in 32. All patients had transesophageal echocardiography before and 3 months after LAAO to assess ITL incidence. The patients were divided according to the presence and absence of ITL and the subgroup of patients with heart failure (HF) were further analyzed. In patients with HF and ITL, an increased VO2max (12.8 ± 5.2 vs 15.3 ± 4.7; P < 0.05) and 6MWD (350.1 ± 77.4 vs 414.3 ± 70.6; P < 0.05) was observed after the procedure comparing to the results before the procedure. The 6MWD was also significantly higher in the patients with transseptal leaks in comparison to those without (P < 0.0001).ConclusionThe presence of transseptal leaks after LAAO does not influence overall cardiac function test results. However, in patients with HF, there is an increase in oxygen consumption and 6MWD. These results indicate that ITLs in patients with HF decrease left atrial pressure, which is the key contributor to the symptoms of heart failure during physical activity.
Periodic limb movements during sleep are associated with cardiovascular diseases: A systematic review and meta‐analysis
Authors: Huang Tien‐Chi , Tseng Ping‐Tao , Wu Meng‐Ni , Stubbs Brendon , Carvalho André F. , Lin Pao‐Yen , Chen Yen‐Wen , Chen Tien‐Yu , Hsu Chung‐Yao 
Published: June 2018

SummaryPeriodic limb movements during sleep present with repetitive movements, typically in the lower limbs, during sleep. Periodic limb movements during sleep have been proposed to be associated with increased risk of heart diseases. The aim of this study was to examine the co‐morbidity rates of heart disease, including acute myocardial infarction, coronary artery disease and cardiovascular disease, in subjects with or without periodic limb movements during sleep through a meta‐analysis. An electronic review of PubMed, Embase, ScienceDirect, Cochrane Library, ProQuest, Web of Science, ClinicalKey and ClinicalTrials.gov was performed. Clinical studies, case‐controlled trials and cohort studies were all included in the search. Case reports or series, and non‐clinical studies were excluded. A meta‐analysis of the results of six studies comparing the prevalence of coronary artery disease/acute myocardial infarction/cardiovascular disease in subjects with/without periodic limb movements during sleep was performed. There were significantly higher co‐morbidity rates of coronary artery disease (odds ratio = 1.568, 95% confidence interval: 1.187–2.073, p = 0.002) and cardiovascular disease (odds ratio = 1.279, 95% confidence interval: 1.095–1.494, p = 0.002), but not acute myocardial infarction (odds ratio = 1.272, 95% confidence interval = 0.942–1.718, p = 0.117), in the periodic limb movements during sleep group than in the non‐periodic limb movements during sleep group. This meta‐analysis highlights the importance of a significantly high prevalence of coronary artery disease and cardiovascular disease in subjects with periodic limb movements during sleep. Further studies should be focused on the potential pathophysiology, and whether treatment for periodic limb movements during sleep can improve the outcome of heart disease.
Dantu's mineralogical properties – A view into the composition of Ceres' crust
Authors: Stephan K. , Jaumann R. , Wagner R. , De Sanctis M. C. , Palomba E. , Longobardo A. , Williams D. A. , Krohn K. , Tosi F. , McFadden L. A. , Carrozzo F. G. , Zambon F. , Ammannito E. , Combe J.‐P. , Matz K.‐D. , Schulzeck F. , von der Gathen I. , Roatsch T. , Raymond C. A. , Russell C. T. 
Published: June 2018

AbstractImpact crater Dantu not only exhibits a very complex geological history but also shows an exceptional heterogeneity of its surface composition. Because of its location within a low‐lying region named Vendimia Planitia, which has been proposed to represent an ancient impact basin, Dantu possibly offers a window into the composition of Ceres’s deeper crust, which apparently is enriched in ammonia. Local concentration of carbonates within Dantu or its ejecta blanket may be either exposed or their emplacement induced by the Dantu impact event. Because carbonates can be seen along Dantu's crater walls, exposed due to recent slumping, but also as fresh spots or clusters of spots scattered across the surface, the deposition/formation of carbonates took place over a long time period. The association of several bright spots enriched in carbonates with sets of fractures on Dantu's floor might be accidental. Nevertheless, its morphological and compositional similarity to the faculae in Ceres’s prominent impact crater Occator including its hydrated state does not exclude a cryo‐volcanic origin, i.e., upwelling of carbonate‐enriched brines influenced by H2O ice in the subsurface. Indeed, an isolated H2O ice spot can be identified near Dantu, which shows that ice still exists in Ceres’s subsurface at midlatitudes and that it can exist on the surface for a longer period of time.
The efficiency of light‐emitting diode suction traps for the collection of South African livestock‐associated Culicoides species
Authors: Venter G. J. , Boikanyo S. N. B. , De Beer C. J. 
Published: June 2018

AbstractCulicoides biting midges (Diptera: Ceratopogonidae) are vectors of a range of orbiviruses that cause important veterinary diseases such as bluetongue and African horse sickness. The effective monitoring of Culicoides species diversity and abundance, both at livestock and near potential wildlife hosts, is essential for risk management. The Onderstepoort 220‐V ultraviolet (UV) light trap is extensively used for this purpose. Reducing its power requirements by fitting low‐energy light‐emitting diodes (LEDs) can lead to greater flexibility in monitoring. A comparison of the efficiency of the 220‐V Onderstepoort trap (8‐W fluorescent UV light) with the efficiency of the 220‐V or 12‐V Onderstepoort traps fitted with red, white, blue or green LEDs or a 12‐V fluorescent Onderstepoort trap demonstrated the 220‐V Onderstepoort trap to be the most efficient. All the results showed nulliparous Culicoides imicola Kieffer females to be the dominant grouping. Despite the lower numbers collected, 12‐V traps can be used in field situations to determine the most abundant species.
Role of pannexin 1 channels in load‐induced skeletal response
Authors: Seref‐Ferlengez Zeynep , Urban‐Maldonado Marcia , Sun Hui B. , Schaffler Mitchell B. , Suadicani Sylvia O. , Thi Mia M. 
Published: June 2018

AbstractThe pannexin 1 (Panx1) channel is a mechanosensitive channel that interacts with P2X7 receptors (P2X7R) to form a functional complex that has been shown in vitro to play an essential role in osteocyte mechanosignaling. While the participation of P2X7R in skeletal responses to mechanical loading has been demonstrated, the role of Panx1 and its interplay with P2X7R still remain to be determined. In this study, we use a global Panx1−/− mouse model and in vivo mechanical loading to demonstrate that Panx1 channels play an essential role in load‐induced skeletal responses. We found that absence of Panx1 not only disrupts the P2X7R–Panx1 signaling complex, but also alters load‐induced regulation of P2X7R expression. Moreover, lack of Panx1 completely abolished load‐induced periosteal bone formation. Load‐induced regulation of β‐catenin and sclerostin expression was dysregulated in Panx1−/−, compared to wild‐type, bone. This finding suggests that Panx1 deficiency disrupts Wnt/β‐catenin signaling by lowering β‐catenin while favoring inhibition of bone formation by increasing load‐induced sclerostin expression. This study demonstrates the existence of a Panx1‐dependent mechanosensitive mechanism that not only modulates ATP signaling but also coordinates Wnt/β‐catenin signaling that is essential for proper skeletal response to mechanical loading.
Coexistence of atrioventricular accessory pathways and drug‐induced type 1 Brugada pattern
Authors: Hasdemir Can , Juang Jimmy Jyh‐Ming , Kose Sedat , Kocabas Umut , Orman Mehmet N. , Payzin Serdar , Sahin Hatice , Celen Candan , Ozcan Emin E. , Chen Ching‐Yu Julius , Gunduz Ramazan , Turan Oguzhan E. , Senol Oktay , Burashnikov Elena , Antzelevitch Charles 
Published: June 2018

AbstractBackgroundAtrial arrhythmias, particularly atrioventricular nodal reentrant tachycardia, can coexist with drug‐induced type 1 Brugada electrocardiogram (ECG) pattern (DI‐Type1‐BrP). The present study was designed to determine the prevalence of DI‐Type1‐BrP in patients with atrioventricular accessory pathways (AV‐APs) and to investigate the clinical, electrocardiographic, electrophysiologic, and genetic characteristics of these patients.MethodsOne‐hundred twenty‐four consecutive cases of AV‐APs and 84 controls underwent an ajmaline challenge test to unmask DI‐Type1‐BrP. Genetic screening and analysis was performed in 55 of the cases (19 with and 36 without DI‐Type1‐BrP).ResultsPatients with AV‐APs were significantly more likely than controls to have a Type1‐BrP unmasked (16.1 vs 4.8%, P = 0.012). At baseline, patients with DI‐Type1‐BrP had higher prevalence of chest pain, QR/rSr’ pattern in V1 and QRS notching/slurring in V2 and aVL during preexcitation, rSr’ pattern in V1‐V2, and QRS notching/slurring in aVL during orthodromic atrioventricular reentrant tachycardia (AVRT) compared to patients without DI‐Type1‐BrP. Abnormal QRS configuration (QRS notching/slurring and/or fragmentation) in V2 during preexcitation was present in all patients with DI‐Type1 BrP. The prevalence of spontaneous preexcited atrial fibrillation (AF) and history of AF were similar (15% vs 18.3%, P = 0.726) in patients with and without DI‐Type1‐BrP, respectively. The prevalence of mutations in Brugada‐susceptibility genes was higher (36.8% vs 8.3%, P = 0.02) in patients with DI‐Type1‐BrP compared to patients without DI‐Type1‐BrP.ConclusionsDI‐Type1‐BrP is relatively common in patients with AV‐APs. We identify 12‐lead ECG characteristics during preexcitation and orthodromic AVRT that point to an underlying type1‐BrP, portending an increased probability for development of malignant arrhythmias.
Cryoablation of the right anteroseptal or midseptal accessory pathways in children: A 2‐year single‐center experience
Authors: Jiang He , Li Xiaomei 
Published: June 2018

AbstractBackgroundRadiofrequency catheter ablation (RFCA) in the septum close to the atrioventricular node or His bundle has an increased risk of irreversible complications. Cryothermal energy has the advantages of reversible cryomapping and increased catheter stability. The study aims to evaluate the efficacy and safety of cryoablation of the right anteroseptal or midseptal accessory pathways (APs) in pediatric patients.MethodA retrospective review was performed with 26 pediatric patients (16 males and 10 females; median age 6.0 years and average body weight 24.9 kg) with paroxysmal supraventricular tachycardia (PSVT) in our Pediatric Heart Center from 2014 to 2016. Half of them had manifest APs. All the children underwent cryoablation for the treatment of PSVT because of the right anteroseptal or midseptal APs (16 cases had right anteroseptal APs and 10 cases had right midseptal APs).ResultsAcute cryoablation success was achieved in 23 cases (88%, 23/26). Atrioventricular block (AVB) occurred in eight cases (31%, 8/26) during the procedures and normal atrioventricular conduction recovered in seven cases except a case with I°AVB. During follow‐up, three cases recurred (13%, 3/23) and no permanent high degree AVB was found.ConclusionCryoablation of the right anteroseptal or midseptal APs in pediatric patients is both safe and effective.
Journeys through discrete‐character morphospace: synthesizing phylogeny, tempo, and disparity
Authors: Lloyd Graeme T. 
Published: June 2018

AbstractPalaeontologists have long employed discrete categorical data to capture morphological variation in fossil species, using the resulting character–taxon matrices to measure evolutionary tempo, infer phylogenies and capture morphological disparity. However, to date these have been seen as separate approaches despite a common goal of understanding morphological evolution over deep time. Here I argue that there are clear advantages to considering these three lines of enquiry in a single space: the phylomorphospace. Conceptually these high‐dimensional spaces capture how a phylogenetic tree explores morphospace and allow us to consider important process questions around evolutionary rates, constraints, convergence and directional trends. Currently the literature contains fundamentally different approaches used to generate such spaces, with no direct comparison between them, despite the differing evolutionary histories they imply. Here I directly compare five different phylomorphospace approaches, three with direct literature equivalents and two that are novel. I use a single empirical case study of coelurosaurian theropod dinosaurs (152 taxa, 853 characters) to show that under many analyses the literature‐derived approaches tend to reflect introduced phylogenetic (rather than the intended morphological) signal. The two novel approaches, which produce limited ancestral state estimates prior to ordination, are able to minimize this phylogenetic signal and thus exhibit more realistic amounts of phylogenetic signal, rate heterogeneity, and convergent evolution.
Widening the genetic base of cultivated gene pool following introgression from wild Lens taxa
Authors: Singh Mohar , Sharma Shyam K. , Singh Badal , Malhotra Nikhil , Chandora Rahul , Sarker Ashutosh , Singh Kuldeep , Gupta Dorin 
Published: June 2018

AbstractWild Lens taxa are a reservoir of useful rare genes/alleles for widening the genetic base and synthesis of a new gene pool of lentil. To maximize and sustain lentil production, new gene sources are needed to be identified and incorporated into cultivated background. This needs a comprehensive approach to accumulate favourable alleles from distantly related germplasm for widening of the cultivated gene pool and would be the most appropriate strategy to solve the various problems associated with stressed crop production and plateaued yields. Furthermore, expansion of deeper understanding of lentil genomics along with extensive research undertaken in other crop species can provide suitable guidelines to cover the distribution of Lens genus and component gene pools for further remarkable progress in lentil genetic improvement. This review aims at the genus Lens distribution and gene pools, crop germplasm conserved in ex‐situ and in‐situ collection, wild species characterization and evaluation for useful traits of interest to solve production‐related problems, highlight useful gene sources present in different gene pools and the progress achieved for widening the genetic base of cultivated varieties of lentil through wide hybridization and exploring lentil genomics.
The relationship between naevus count, memory function and telomere length in the Twins UK cohort
Authors: Masi Stefano , Georgiopoulos Georgios , Ribero Simone , Taddei Stefano , Bataille Veronique , Steves Claire J. 
Published: June 2018

AbstractThe presence of a skin–brain connection whereby alterations in the skin can inform on mechanisms underlying neurodegenerative diseases is increasingly recognized. In this study, we used a discovery (n = 321) and replication (n = 147) sample from the Twins UK population to test the association between naevus count and memory function, and its mediation by telomeres. Memory function was assessed in 1999 and 2009 using the paired associates learning test (PAL), while naevus count and leucocyte telomere length (LTL, assessed by the terminal restriction fragment assay) were measured once. Higher baseline naevus count was significantly associated with fewer errors at the baseline and follow‐up PAL, as well as with change in PAL score over 10 years. This association was significantly attenuated after adjustment for LTL. The significant association between naevus count and PAL score was reproduced in the replication sample. These findings suggest that melanocytes might be used as model system to study the biological ageing pathways involved in neurodegeneration.
The intrinsic probability of theism
Authors: Miller Calum 
Published: June 2018

AbstractIn this paper, I explore one of the most important but least discussed components of an evidentialist case for or against theism: its intrinsic plausibility and simplicity as a theory aside from the evidence. This is a crucial consideration in any inductive framework, whether Inference to the Best Explanation, probabilism, or another. In the context of Bayesian reasoning, this corresponds to an assessment of theism's intrinsic probability. I offer a survey of how philosophers of science have attempted to evaluate the intrinsic plausibility and simplicity of scientific theories more generally, before applying these considerations to the question of God's existence.
The potato transcription factor StbZIP61 regulates dynamic biosynthesis of salicylic acid in defense against Phytophthora infestans infection
Authors: Zhou Xin‐Tong , Jia Li‐Jia , Wang Hai‐Yun , Zhao Pan , Wang Wen‐Yan , Liu Ning , Song Shuang‐Wei , Wu Yao , Su Lei , Zhang Jie , Zhong Nai‐Qin , Xia Gui‐Xian 
Published: June 2018

SummarySalicylic acid (SA) signalling plays an essential role in plant innate immunity. In this study, we identified a component in the SA signaling pathway in potato (Solanum tuberosum), the transcription factor StbZIP61, and characterized its function in defence against Phytophthora infestans. Expression of StbZIP61 was induced upon P. infestans infection and following exposure to the defense signaling hormones SA, ethylene and jasmonic acid. Overexpression of StbZIP61 increased the tolerance of potato plants to P. infestans while RNA interference (RNAi) increased susceptibility. Yeast two‐hybrid and pull down experiments revealed that StbZIP61 could interact with an NPR3‐like protein (StNPR3L) that inhibited its DNA‐binding and transcriptional activation activities. Moreover, StNPR3L interacted with StbZIP61 in an SA‐dependent manner. Among candidate genes involved in SA‐regulated defense responses, StbZIP61 had a significant impact on expression of StICS1, which encodes a key enzyme for SA biosynthesis. StICS1 transcription was induced upon P. infestans infection and this responsive expression to the pathogen was reduced in StbZIP61 RNAi plants. Accordingly, StICS1 expression was remarkably enhanced in StbZIP61‐overexpressing plants. Together, our data demonstrate that StbZIP61 functions in concert with StNPR3L to regulate the temporal activation of SA biosynthesis, which contributes to SA‐mediated immunity against P. infestans infection in potato.