bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional tract‐specific white matter hyperintensities are associated with patterns of aging‐related brain atrophy via vascular risk factors, but also independently
Authors: Habes Mohamad , Erus Guray , Toledo Jon B. , Bryan Nick , Janowitz Deborah , Doshi Jimit , Völzke Henry , Schminke Ulf , Hoffmann Wolfgang , Grabe Hans J. , Wolk David A. , Davatzikos Christos 
Published: March 2018

AbstractIntroductionWe sought to investigate associations of regional white matter hyperintensities (WMHs) within white matter (WM) tracts with cardiovascular risk and brain aging‐related atrophy throughout adulthood in the general population, leveraging state of the art pattern analysis methods.MethodsWe analyzed a large sample (n = 2367) from the Study of Health in Pomerania, Germany (range 20–90 years). WMHs were automatically segmented on T1‐weighted and fluid‐attenuated inversion recovery magnetic resonance images, and WMH volumes were calculated in WM regions defined using the John Hopkins University WM tractography atlas. Regions with the highest average WMH volume were selected. We calculated a subject‐specific index, Spatial Pattern of Alteration for Recognition of Brain Aging, to measure age‐related atrophy patterns. The Framingham cardiovascular disease risk score summarized the individual cardiovascular risk profile. We used structural equation models, independently for each region, using Spatial Pattern of Alteration for Recognition of Brain Aging as a dependent variable, age as an independent variable, and cardiovascular disease risk score and regional WMH volumes as mediators.ResultsSelected 12 WM regions included 75% of the total WMH burden in average. Structural equation models showed that the age effect on Spatial Pattern of Alteration for Recognition of Brain Aging was mediated by WMHs to a different extent in the superior frontal WM, anterior corona radiata, inferior frontal WM, superior corona radiata, superior longitudinal fasciculus, middle temporal WM, posterior corona radiata, superior parietal WM, splenium of corpus callosum, posterior thalamic radiation, and middle occipital WM (variance explained between 2.8% and 10.3%, P < .0001 Bonferroni corrected), but not in precentral WM.ConclusionsOur results indicate that WMHs, in most WM tracts, might accelerate the brain aging process throughout adulthood in the general population as a result of vascular risk factors, but also independent of them. Preventive strategies against WMHs (such as controlling vascular risk factors or microglia depletion) could delay brain aging.
A Network Approach to Hypersexuality: Insights and Clinical Implications
Authors: Werner Marlene , Štulhofer Aleksandar , Waldorp Lourens , Jurin Tanja 
Published: March 2018

Abstract

Background
In spite of a growing interest in research on hypersexuality, consensus about its etiology and best treatment strategy has not been achieved.

Aim
To further the empirical and clinical understanding of hypersexuality by exploring the structure of its symptoms using a network analytic approach.

Methods
In 2014, an online survey advertised as focusing on Internet pornography, sexual health, and relationships was carried out among Croatian men and women aged 18–60 years (Mage = 31.1 years, SD = 9.67). In a sample of 3,028 participants, we applied a network analytic approach to explore the structure of hypersexuality symptoms. In the network, nodes represented hypersexuality symptoms and associated sexual behaviors, while their connections were operationalized as partial correlations. 4 Research questions were addressed: (1) does the hypersexuality network differ between genders; (2) which symptoms are centrally positioned; (3) what is the topological location of pornography use; and (4) are there distinct clusters (“communities”) of symptoms in the network?

Outcomes
We estimated and plotted hypersexuality networks by gender using items from the Hypersexual Disorder Screening Inventory and the Hypersexual Behavioral Consequences Scale, as well as indicators of sexual desire, pornography use, sexual intercourse, and masturbation frequency.

Results
The structure of the hypersexuality network was surprisingly similar in women and men, both in terms of symptom centrality and the clustering of symptoms. Psychological distress and negative emotions triggered by sexual fantasies and/or behaviors, together with a loss of control over sexual feelings, occupied central positions in the networks. Pornography use was located peripherally in both the men’s and women’s hypersexuality networks.

Clinical Translation
Psychological distress and negative emotions triggered by sexual fantasies and/or behaviors constituted the core of the hypersexuality network, which makes them potential prime targets for clinical intervention and calls for normalization of (presumably self-stigmatized) sexual expression through affirmative therapy and interventions that enhance self-care, self-compassion, and adaptive coping mechanisms.

Strengths & Limitations
This is the first network analytic approach to hypersexuality. Apart from its novel insights about the structure of hypersexuality, the study employed several methods to assure reliability and robustness of findings. Considering that networks were estimated in a convenience-based community sample, the findings might not generalize to clinically distressed individuals.

Conclusion
Our results demonstrate the usefulness of network analytics to hypersexuality in a non-clinical sample and we encourage future clinical and longitudinal explorations of hypersexuality using this novel approach.
Method for detection of leads from Sentinel-1 SAR images
Authors: Murashkin Dmitrii , Spreen Gunnar , Huntemann Marcus , Dierking Wolfgang 
Published: March 2018

ABSTRACTThe presence of leads with open water or thin ice is an important feature of the Arctic sea ice cover. Leads regulate the heat, gas and moisture fluxes between the ocean and atmosphere and are areas of high ice growth rates during periods of freezing conditions. Here, an algorithm providing an automatic lead detection based on synthetic aperture radar images is described that can be applied to a wide range of Sentinel-1 scenes. By using both the HH and the HV channels instead of single co-polarised observations the algorithm is able to classify more leads correctly. The lead classification algorithm is based on polarimetric features and textural features derived from the grey-level co-occurrence matrix. The Random Forest classifier is used to investigate the importance of the individual features for lead detection. The precision–recall curve representing the quality of the classification is used to define threshold for a binary lead/sea ice classification. The algorithm is able to produce a lead classification with more that 90% precision with 60% of all leads classified. The precision can be increased by the cost of the amount of leads detected. Results are evaluated based on comparisons with Sentinel-2 optical satellite data.
Land to sea transitions in vertebrates: the dynamics of colonization
Authors: Vermeij Geerat J. , Motani Ryosuke 
Published: March 2018

AbstractVertebrates with terrestrial or freshwater ancestors colonized the sea from the Early Triassic onward and became competitively dominant members of many marine ecosystems throughout the Mesozoic and Cenozoic eras. The circumstances that led to initial marine colonization have, however, received little attention. One hypothesis is that mass extinction associated with ecosystem collapse provided opportunities for clades of amphibians, reptiles, birds, and mammals to enter marine environments. Another is that competitive pressures in donor ecosystems on land and in freshwater, coupled with abundant food in nearshore marine habitats, favored marine colonization. Here we test these hypotheses by compiling all known secondarily marine amniote clades and their times of colonization. Marine amniotes are defined as animals whose diet consists primarily of marine organisms and whose locomotion includes swimming, diving, or wading in salt water. We compared the number of clades entering during recovery phases from mass extinctions with the rate of entry of clades during nonrecovery intervals of the Mesozoic and Cenozoic. We conservatively identify 69 marine colonizations by amniotes. The only recovery interval for which prior mass extinction could have been a trigger for marine entry is the Early Triassic, when four clades colonized the sea over 7 Myr, significantly above the rates at which clades entered during other intervals. High nearshore productivity was a greater enticement to colonization than was a low diversity of potential marine competitors or predators in nearshore environments of a highly competitive terrestrial or freshwater donor biota. Rates of marine entry increased during the Cenozoic, in part because of rising productivity and in part thanks to the participation of warm-blooded birds and mammals, which broadened the range of thermal environments in which initial colonization of the sea became possible.
Maternal high-salt diet alters redox state and mitochondrial function in newborn rat offspring’s brain
Authors: Stocher Daniela P. , Klein Caroline P. , Saccomori André B. , August Pauline M. , Martins Nicolli C. , Couto Pablo R. G. , Hagen Martine E. K. , Matté Cristiane 
Published: March 2018

AbstractExcessive salt intake is a common feature of Western dietary patterns, and has been associated with important metabolic changes including cerebral redox state imbalance. Considering that little is known about the effect on progeny of excessive salt intake during pregnancy, the present study investigated the effect of a high-salt diet during pregnancy and lactation on mitochondrial parameters and the redox state of the brains of resulting offspring. Adult female Wistar rats were divided into two dietary groups (n20 rats/group): control standard chow (0·675 % NaCl) or high-salt chow (7·2 % NaCl), received throughout pregnancy and for 7 d after delivery. On postnatal day 7, the pups were euthanised and their cerebellum, hypothalamus, hippocampus, prefrontal and parietal cortices were dissected. Maternal high-salt diet reduced cerebellar mitochondrial mass and membrane potential, promoted an increase in reactive oxygen species allied to superoxide dismutase activation and decreased offspring cerebellar nitric oxide levels. A significant increase in hypothalamic nitric oxide levels and mitochondrial superoxide in the hippocampus and prefrontal cortex was observed in the maternal high-salt group. Antioxidant enzymes were differentially modulated by oxidant increases in each brain area studied. Taken together, our results suggest that a maternal high-salt diet during pregnancy and lactation programmes the brain metabolism of offspring, favouring impaired mitochondrial function and promoting an oxidative environment; this highlights the adverse effect of high-salt intake in the health state of the offspring.
Early changes in tissue amino acid metabolism and nutrient routing in rats fed a high-fat diet: evidence from natural isotope abundances of nitrogen and carbon in tissue proteins
Authors: Mantha Olivier L. , Polakof Sergio , Huneau Jean-François , Mariotti François , Poupin Nathalie , Zalko Daniel , Fouillet Helene 
Published: March 2018

AbstractLittle is known about how diet-induced obesity and insulin resistance affect protein and amino acid (AA) metabolism in tissues. The natural relative abundances of the heavy stable isotopes of C (δ13C) and N (δ15N) in tissue proteins offer novel and promising biomarkers of AA metabolism. They, respectively, reflect the use of dietary macronutrients for tissue AA synthesis and the relative metabolic use of tissue AA for oxidationv.protein synthesis. In this study,δ13C andδ15N were measured in the proteins of various tissues in young adult rats exposed perinatally and/or fed after weaning with a normal- or a high-fat (HF) diet, the aim being to characterise HF-induced tissue-specific changes in AA metabolism. HF feeding was shown to increase the routing of dietary fat to all tissue proteins via non-indispensable AA synthesis, but did not affect AA allocation between catabolic and anabolic processes in most tissues. However, the proportion of AA directed towards oxidation rather than protein synthesis was increased in the small intestine and decreased in thetibialis anteriormuscle and adipose tissue. In adipose tissue, the AA reallocation was observed in the case of perinatal or post-weaning exposure to HF, whereas in the small intestine andtibialis anteriormuscle the AA reallocation was only observed after HF exposure that covered both the perinatal and post-weaning periods. In conclusion, HF exposure induced an early reorganisation of AA metabolism involving tissue-specific effects, and in particular a decrease in the relative allocation of AA to oxidation in several peripheral tissues.
Predicting the structure of soil communities from plant community taxonomy, phylogeny, and traits
Authors: Leff Jonathan W , Bardgett Richard D , Wilkinson Anna , Jackson Benjamin G , Pritchard William J , De Long Jonathan R , Oakley Simon , Mason Kelly E , Ostle Nicholas J , Johnson David , Baggs Elizabeth M , Fierer Noah 
Published: March 2018

Abstract
There are numerous ways in which plants can influence the composition of soil communities. However, it remains unclear whether information on plant community attributes, including taxonomic, phylogenetic, or trait-based composition, can be used to predict the structure of soil communities. We tested, in both monocultures and field-grown mixed temperate grassland communities, whether plant attributes predict soil communities including taxonomic groups from across the tree of life (fungi, bacteria, protists, and metazoa). The composition of all soil community groups was affected by plant species identity, both in monocultures and in mixed communities. Moreover, plant community composition predicted additional variation in soil community composition beyond what could be predicted from soil abiotic characteristics. In addition, analysis of the field aboveground plant community composition and the composition of plant roots suggests that plant community attributes are better predictors of soil communities than root distributions. However, neither plant phylogeny nor plant traits were strong predictors of soil communities in either experiment. Our results demonstrate that grassland plant species form specific associations with soil community members and that information on plant species distributions can improve predictions of soil community composition. These results indicate that specific associations between plant species and complex soil communities are key determinants of biodiversity patterns in grassland soils.
Altered brainstem responses to modafinil in schizophrenia: implications for adjunctive treatment of cognition
Authors: Minzenberg Michael J. , Yoon Jong H. , Soosman Steffan K. , Carter Cameron S. 
Published: March 2018

AbstractCandidate pro-cognitive drugs for schizophrenia targeting several neurochemical systems have consistently failed to demonstrate robust efficacy. It remains untested whether concurrent antipsychotic medications exert pharmacodynamic interactions that mitigate pro-cognitive action in patients. We used functional MRI (fMRI) in a randomized, double-blind, placebo-controlled within-subject crossover test of single-dose modafinil effects in 27 medicated schizophrenia patients, interrogating brainstem regions where catecholamine systems arise to innervate the cortex, to link cellular and systems-level models of cognitive control. Modafinil effects were evaluated both within this patient group and compared to a healthy subject group. Modafinil modulated activity in the locus coeruleus (LC) and ventral tegmental area (VTA) in the patient group. However, compared to the healthy comparison group, these effects were altered as a function of task demands: the control-independent drug effect on deactivation was relatively attenuated (shallower) in the LC and exaggerated (deeper) in the VTA; in contrast, again compared to the comparison group, the control-related drug effects on positive activation were attenuated in LC, VTA and the cortical cognitive control network. These altered effects in the LC and VTA were significantly and specifically associated with the degree of antagonism of alpha-2 adrenergic and dopamine-2 receptors, respectively, by concurrently prescribed antipsychotics. These sources of evidence suggest interacting effects on catecholamine neurons of chronic antipsychotic treatment, which respectively increase and decrease sustained neuronal activity in LC and VTA. This is the first direct evidence in a clinical population to suggest that antipsychotic medications alter catecholamine neuronal activity to mitigate pro-cognitive drug action on cortical circuits.
Author Correction: High Energy Radical Chemistry Formation of HCN-rich Atmospheres on early Earth
Authors: Ferus Martin , Kubelík Petr , Knížek Antonín , Pastorek Adam , Sutherland John , Civiš Svatopluk 
Published: March 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Months-long real-time generation of a time scale based on an optical clock
Authors: Hachisu Hidekazu , Nakagawa Fumimaru , Hanado Yuko , Ido Tetsuya 
Published: March 2018

AbstractTime scales consistently provide precise time stamps and time intervals by combining atomic frequency standards with a reliable local oscillator. Optical frequency standards, however, have not been applied to the generation of time scales, although they provide superb accuracy and stability these days. Here, by steering an oscillator frequency based on the intermittent operation of a 87Sr optical lattice clock, we realized an “optically steered” time scale TA(Sr) that was continuously generated for half a year. The resultant time scale was as stable as International Atomic Time (TAI) with its accuracy at the 10−16 level. We also compared the time scale with TT(BIPM16). TT(BIPM) is computed in deferred time each January based on a weighted average of the evaluations of the frequency of TAI using primary and secondary frequency standards. The variation of the time difference TA(Sr) – TT(BIPM16) was 0.79 ns after 5 months, suggesting the compatibility of using optical clocks for time scale generation. The steady signal also demonstrated the capability to evaluate one-month mean scale intervals of TAI over all six months with comparable uncertainties to those of primary frequency standards (PFSs).
Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells
Authors: Vanshylla Kanika , Bartsch Caren , Hitzing Christoffer , Krümpelmann Laura , Wienands Jürgen , Engels Niklas 
Published: March 2018

AbstractThe B cell antigen receptor (BCR) employs enzymatically inactive adaptor proteins to facilitate activation of intracellular signaling pathways. In animal model systems, adaptor proteins of the growth factor receptor-bound 2 (Grb2) family have been shown to serve critical functions in lymphocytes. However, the roles of Grb2 and the Grb2-related adaptor protein (GRAP) in human B lymphocytes remain unclear. Using TALEN-mediated gene targeting, we show that in human B cells Grb2 and GRAP amplify signaling by the immunoglobulin tail tyrosine (ITT) motif of mIgE-containing BCRs and furthermore connect immunoreceptor tyrosine-based activation motif (ITAM) signaling to activation of the Ras-controlled Erk MAP kinase pathway. In contrast to mouse B cells, BCR-induced activation of Erk in human B cells is largely independent of phospholipase C-ɣ activity and diacylglycerol-responsive members of Ras guanine nucleotide releasing proteins. Together, our results demonstrate that Grb2 family adaptors are critical regulators of ITAM and ITT signaling in naïve and IgE-switched human B cells.
ZFP226 is a novel artificial transcription factor for selective activation of tumor suppressor KIBRA
Authors: Schelleckes Katrin , Schmitz Boris , Lenders Malte , Mewes Mirja , Brand Stefan-Martin , Brand Eva 
Published: March 2018

AbstractKIBRA has been suggested as a key regulator of the hippo pathway, regulating organ size, cell contact inhibition as well as tissue regeneration and tumorigenesis. Recently, alterations of KIBRA expression caused by promotor methylation have been reported for several types of cancer. Our current study aimed to design an artificial transcription factor capable of re-activating expression of the tumor suppressor KIBRA and the hippo pathway. We engineered a new gene named ‘ZFP226′ encoding for a ~23 kDa fusion protein. ZFP226 belongs to the Cys2-His2 zinc finger type and recognizes a nine base-pair DNA sequence 5′-GGC-GGC-GGC-3′ in the KIBRA core promoter P1a. ZFP226 showed nuclear localization in human immortalized kidney epithelial cells and activated the KIBRA core promoter (p < 0.001) resulting in significantly increased KIBRA mRNA and protein levels (p < 0.001). Furthermore, ZFP226 led to activation of hippo signaling marked by elevated YAP and LATS phosphorylation. In Annexin V flow cytometry assays ZFP226 overexpression showed strong pro-apoptotic capacity on MCF-7 breast cancer cells (p < 0.01 early-, p < 0.001 late-apoptotic cells). We conclude that the artificial transcription factor ZFP226 can be used for target KIBRA and hippo pathway activation. This novel molecule may represent a molecular tool for the development of future applications in cancer treatment.