bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidential Deep Learning for Guided Drug-Target Interaction Prediction
Authors: He Song , Zhao Yanpeng , Xing Yuting , Zhang Yixin , Wang Yifei , Wu Chengkun , Li Shangze , Xu Huiyan , Han Tianyu , Zhang Hongyang , Liu Ziyi , Zhou Guowei , Li Mengfan , Wang Xuanze , Chen Zhengshan , Li Ruijiang , Wu Lianlian , Zhao Dongsheng , Bo Xiaochen 
Published: November 2024

Abstract

Drug-target interaction (DTI) prediction is a crucial component of drug discovery. Recent deep learning methods show great potential in this field but also encounter substantial challenges. These include generating reliable confidence estimates for predictions, enhancing robustness when handling novel, unseen DTIs, and mitigating the tendency toward overconfident and incorrect predictions. To solve these problems, we propose EviDTI, a novel approach utilizing evidential deep learning (EDL) for uncertainty quantification in neural network-based DTI prediction. EviDTI integrates multiple data dimensions, including drug 2D topological graphs and 3D spatial structures, and target sequence features. Through EDL, EviDTI provides uncertainty estimates for its predictions. Experimental results on three benchmark datasets demonstrated the competitiveness of EviDTI against five state-of-the-art baseline models. In addition, our study shows that EviDTI can calibrate prediction errors. More importantly, well-calibrated uncertainty information enhanced the efficiency of drug discovery by prioritizing DTIs with higher confident predictions for experimental validation. In a case study focused on tyrosine kinase inhibitors (TKIs), uncertainty-guided predictions identified novel potential inhibitors targeting FAK and FLT3. These results underscore the potential of evidential deep learning as a robust tool for uncertainty quantification in DTI prediction and its broader implications for accelerating drug discovery.
Spatial distribution, genetic analysis, and population structure of the invasive Anopheles stephensi in Kenya: 2022-2024
Authors: Samake Jeanne N. , Athinya Duncan K. , Milanoi Sylvia , Ramaita Edith , Muchoki Margaret , Omondi Seline , Abong’o Bernard , Matoke-Muhia Damaris , Mbogo Charles , Keitany Kibor , Mukabana Wolfgang Richard , Oyieke Florence , Shieshia Mildred , Mburu Monica , Ogoma Sheila , Nyawira Elizabeth , Wekesa Celestine , Bartilol Brian , Rono Martin , Maia Marta , O’Meara Wendy , Kahindi Samuel , Rafferty Cristina , Schultz Jonathan S. , Gutman Julie R. , Gimnig John E. , Zohdy Sarah , Ochomo Eric 
Published: November 2024

Abstract

This study analyzes the distribution, genetic diversity, and spread of An. stephensi in Kenya following initial detection in December 2022. A total of 114 larval and 33 adult An. stephensi samples were confirmed in 7 of 18 surveyed counties majorly along transportation routes. Genetic analyses revealed three distinct genetic compositions with different levels of genetic diversity, suggesting multiple introductions into the country. The genetic composition of mosquitoes in most counties resembled southern Ethiopian populations, while those from Turkana showed a unique haplotype. A species distribution model predicts a more extensive range than currently observed, with low precipitation and minimal seasonal temperature variations as key factors influencing distribution. Challenges in adult sampling were noted, with larval sampling revealing co-occurrence with native Anopheles species. The findings have implications for surveillance and control strategies, emphasizing the need for continued monitoring, refined sampling techniques to inform bionomics, and cross-border collaboration.
Seroprevalence of Treponema pallidum antibodies and community knowledge, attitudes, and practices related to yaws in the middle belt of Ghana: A quantitative cross-sectional study
Authors: Nyarko Prince , Acheampong Anabel , Kudzordzi Prince Charles , Ofori Dennis Kyei , Blay Edwina Twum , Owusu Philip Antwi , Yeboah Godfred , Boakye Oppong Owusu , Henyo Albert , Datsa Lydia , Oduro Paulina Pokua , Nsiede Claudia Wubuareyasa , Ansah Emmanuel Boateng , Veriegh Francis Balungnaa Dhari , Otabil Kenneth Bentum 
Published: November 2024

Abstract

Background
The paucity of epidemiological data on yaws in Ghana hampers national eradication efforts. This study aimed to investigate the seroprevalence of T. pallidum antibodies and community knowledge, attitudes, and practices toward yaws in the middle belt of Ghana.
Methods
A cross-sectional, quantitative study was performed between June 2021 and October 2021. A total of 138 participants—63.8% (88) female, with a median age of 32.7 years—were recruited from five study communities. Blood samples were taken to test for antibodies against T. pallidum, and a questionnaire on knowledge, attitudes and practices toward yaws was administered.
Results
The overall seroprevalence of antibodies against T. pallidum was 38% (52/137) [95% CI: 30.3 − 46.3], the highest of which was 63.3% (19/30) 19/30 [95% CI: 45.5 − 78.1] in State Farms, followed by 46.8% (22/47) [95% CI: 33.3 − 60.8] in Branam and 38.5% (10/26) [95% CI: 22.4 − 57.5] in Abekwai 3. Only 54.3% (75/138) had a good level of knowledge, 40.6% (56/138) had a high level of positive attitudes, and 58.7% (81/138) had a high level of good practices toward yaws. Having a formal education significantly increased the odds of having a high level of knowledge on yaws (OR = 2.299, P = 0.045, 95% CI = 1.020–5.180). The participants with a high level of knowledge were 8 times more likely to have a high level of positive attitudes (OR = 8.407, P < .001, 95% CI = 3.702–19.090), whereas a high level of good attitudes also significantly increased the odds of having a high level of positive practices (OR = 2.870, P = .005, 95% CI = 1.379–5.970). Being ≥ 30 years old significantly increased the odds of having a high level of positive attitudes and positive practices.
Conclusions
Despite high seropositivity of T. pallidum antibodies, there was an inadequate level of knowledge, good attitudes, and good practices toward yaws in our study communities. We highlight the need for sustained, targeted educational and sociobehavioral change campaigns by the Ghana Yaws Eradication Program to improve community knowledge, attitudes and practices and help reduce the transmission of the disease in communities.
Departing Classroom Constraints: Learners’ Shift to VR for Language Self-study Amidst Methodology, Atmosphere, and Time Challenges
Authors: Ardalani Masoud 
Published: November 2024

Abstract

Language education is undergoing significant transformation driven by psychological factors and technological advancements. Traditional learning environments present various challenges, including methodological limitations, psychological barriers related to learning atmosphere, and time-management constraints. This study investigated the interrelationship between these challenges (termed the M.A.T. framework) and learners’ tendencies toward self-study approaches, while exploring Virtual Reality (VR) technology as a potential solution in addressing these multifaceted learning barriers. Through a targeted survey of 106 self-study language learners—a specialized population characterized by their autonomous learning approach and typically difficult to access— I examined both the drivers of self-study choices and attitudes toward VR adoption.
For the research methodology, I employed both quantitative analysis and psychological assessment to understand learners’ motivations and technological acceptance. Logistic regression analysis revealed that learners facing time-management (OR: 5.46, 95% CI: 1.65-18.09) and psychological atmosphere-related challenges (OR: 4.66, 95% CI: 1.18-18.40) were significantly more likely to consider VR solutions compared to those experiencing methodological challenges. Notably, 72% of participants showed willingness to try VR language learning, while methodology-related challenges demonstrated lower relevance than initially hypothesized.
In this study I combined quantitative survey techniques with psychological insights, contributing to our understanding of how technological solutions might address traditional learning environment challenges leading to educational change. These findings have significant implications for educational technology development, learning environment design, and the future implementation of VR in language education. Furthermore, the results suggest a shifting paradigm in language learning methodology, where technological solutions could effectively address psychological and time-management barriers in educational settings.
A Multivariable Newton-Based Stochastic Extremum Seeking Control for Systems with Distinct Input Delays
Authors: Silva Paulo Cesar Souza , Pellanda Paulo Cesar , Oliveira Tiago Roux 
Published: November 2024

Abstract

This paper introduces a novel multivariable Newton-based stochastic extremum-seeking control method for real-time optimization in multi-input systems with distinct input delays. The proposed approach integrates predictor-based feedback and Hessian inverse estimation, achieved through stochastic sinusoidal perturbations, to allow delay compensation while ensuring user-defined convergence rates. This method preserves exponential stability and guarantees convergence to a small neighborhood around the unknown extremum point, even under arbitrarily long delays in actuator channels. The control scheme is further extended to accommodate multi-input, single-output maps with cross-coupled channels, thereby addressing complex, delayed interactions that frequently arise in real-world control systems. Stability analysis is rigorously derived using backstepping transformations and infinite-dimensional averaging techniques, establishing a strong theoretical foundation for robust performance in dynamic settings. Numerical simulations illustrate the proposed method’s effectiveness in delay compensation, highlighting both the challenges and the benefits of managing time-delayed channels in real-time optimization.
Między powinnościami a możliwościami. Funkcjonowanie redakcji mniejszości ukraińskiej w Polskim Radiu w pierwszym półroczu wojny w Ukrainie
Authors: Szydłowska Magdalena 
Published: November 2024

Autorka analizuje funkcjonowanie redakcji mniejszości ukraińskiej przy regionalnych rozgłośniach nadawcy publicznego, wprowadzone tam zmiany organizacyjne i programowe w pierwszych miesiącach wojny. Podstawą analizy są wywiady z dziennikarzami rozgłośni, ramówki z 2022 roku, a także zalecenia w sprawie podwyższenia bezpieczeństwa teleinformatycznego i zarządzenie w sprawie wprowadzenia stopnia alarmowego CRP Prezesa Rady Ministrów.
Rola oświadczenia w zarządzaniu informacją w kryzysie wizerunkowym influencera w kontekście zasady 5P
Authors: Urbaś Joanna 
Published: November 2024

Jedna z najpopularniejszych zasad organizujących działania w zarządzaniu kryzysowym to zasada 5P autorstwa Adama Łaszyna. Praktyczną formą, w której powinna się spełniać, jest między innymi oświadczenie kryzysowe. Główna hipoteza dotyczy tego, że jego dobra konstrukcja stanowi punkt przełomowy w relacjach z otoczeniem w mediach społecznościowych. Badania przeprowadzono metodą studium przypadku z elementami analizy zawartości. Wnioski płynące z badań potwierdzają hipotezy szczegółowe o tym, jak istotna w oświadczeniach kryzysowych jest nie tylko sama jego konstrukcja, ale też czas publikacji, kanał oraz forma wyrażenia – lub nie – skruchy. Dotychczasowe publikacje dotyczące kryzysów wizerunkowych influencerów powstawały w ramach raportów lub artykułów w portalach branżowych, brakuje natomiast naukowego opracowania tematu. Publikacja wnosi też wartość w postaci autorskiej kategoryzacji oświadczeń kryzysowych, która może stanowić narzędzie, klucz analizy w innych tego typu badaniach w przyszłości.
The Complications after General Anesthesia between Female and Male Genders in the First 24 Hours after Surgery
Authors: Vahabi Sepideh , Beiranvand Siavash , Kiabi Farshad Hassanzadeh , Rastad Hamid 
Published: November 2024

Background
During surgery, the body responds to injury. These physiological responses lead to an imbalance in the physiologic activity of the body.

Objective
This study aimed to compare the incidence of complications after general anesthesia between males and females in the first 24 hours postoperatively.

Methods
This is a cross-sectional study. The study population included 150 patients who were candidates for surgery in the age range of 18-55. The sampling method was simple and sequential, and the selection of samples continued to reach 75 in both male and female groups. The collected data were analyzed by SPSS v.18 software and descriptive statistics, chi-square and Repeated Measure tests. Finally, P <0.05 was considered statistically significant.

Results
The incidence of some complications after general anesthesia was significantly higher in women than in men, including hypertension, tachycardia, tachypnea, restlessness, reduction of SaO2, hypotension, pain, vomiting, nausea, and drowsiness. Also, some complications were observed in women more than men, but they were not statistically significant, including voice violence, urinary retention, bradypnea, and shivering. Bradycardia was the only complication that was seen in men more than women but was not statistically significant. It was also observed that all complications after 24 hours significantly decreased in all patients.

Conclusion
It is suggested that in future studies, this type of study should be conducted with a larger sample size in different populations and compared with other types of anesthetics.
Preferences for Starting Daily, On-Demand, and Long-Acting Injectable HIV Preexposure Prophylaxis Among Men Who Have Sex With Men in the United States (2021-2022): Nationwide Online Cross-Sectional Study
Authors: Islek Duygu , Sanchez Travis , Glick Jennifer L , Jones Jeb , Rawlings Keith , Sarkar Supriya , Sullivan Patrick S , Vannappagari Vani 
Published: November 2024

Background
Long-acting (LA) injectable preexposure prophylaxis (PrEP) and on-demand PrEP may improve overall PrEP uptake among men who have sex with men (MSM), but little is understood about the PrEP option preferences of MSM in practical scenarios where they may choose between various PrEP options.

Objective
This study aims to examine the preferences for starting various PrEP options among a US nationwide online convenience sample of MSM from September 2021 to February 2022.

Methods
Participants reporting no prior HIV diagnosis were provided brief descriptions of each PrEP option and were asked, “If [PrEP option] were available from your local doctor and you could access it for free, would you go to your doctor in the next month to start [PrEP option]?” Those who said “yes” to multiple options were asked to rank them in order of preference. MSM currently taking daily oral (DO) PrEP were asked whether they would switch to on-demand or LA PrEP options. Log binomial models were created to examine the association between willingness to start or switch to on-demand and LA PrEP with various sociodemographic and behavioral factors.

Results
In the analytic sample (N=7760), among the participants who did not use any PrEP in the past 12 months (n=5108, 66%), 54% (n=2445) reported willingness to start at least 1 PrEP option and 41% (n=1845) of participants showed interest in starting multiple PrEP options. Overall, the highest willingness was reported for on-demand PrEP (n=2235, 44%), followed by DO PrEP (n=2174, 43%) and LA PrEP (n=1482, 29%). LA PrEP was ranked first among those interested in multiple options. Characteristics associated with ranking LA PrEP as a first option to start PrEP versus DO or on-demand PrEP were region of residence (residing in the West vs Northeast), report of sexually transmitted infection diagnosis in the past year, report of illicit drug use other than marijuana in the past year, and prior awareness of LA PrEP. Among current DO PrEP users (n=2379, 31%), 58% (n=1386) were willing to switch to on-demand or LA PrEP, and LA PrEP was ranked first among participants who were open to switching to both options. Willingness to switch to LA PrEP was higher among those who used illicit drugs other than marijuana in the past year, who heard of LA PrEP prior to the survey, and those who took 15 or less doses of oral PrEP in the last 30 days.

Conclusions
LA PrEP was the highest-ranked option among most MSM who were willing to try multiple options or switch from DO PrEP. These findings highlight that LA PrEP might fill coverage gaps among MSM who use illicit drugs, have had a recent sexually transmitted infection diagnosis, and have less than optimal DO PrEP adherence.
Kajian Bahaya Potensial Ergonomi pada Pengrajin Batik (Studi Kasus Pengrajin Batik di Kelurahan Ulu Gedong)
Authors: Prasetyo Yodi , Aswin Budi , Reskiaddin La Ode 
Published: November 2024

Sektor informal minim dalam menerapkan K3 di lingkungan kerja termasuk pembatik. Proses dalam pekerjaan membatik berisiko menimbulkan bahaya ergonomi. Tujuan penelitian ini adalah mengetahui bahaya potensial ergonomi pada pengrajin batik di kelurahan Ulu Gedong. Metode penelitian menggunakan kualitatif dengan pendekatan studi kasus. Informan penelitian didapatkan dengan teknik snowball sampling sebanyak 6 pembatik dan 9 informan pendukung. Data dikumpulkan melalui wawancara mendalam dan observasi. Data dianalisis menggunakan pendekatan konten analisis. Hasil penelitian bahwa potensi risiko bahaya pada aspek man machine-system terkait penggunaan alat dalam waktu lama dan gerakan repetisi pengambilan lilin. Aspek sikap kerja terkait posisi duduk tidak ergonomis dan durasi duduk lama. Aspek layout stasiun kerja terkait bekerja tidak pada ruangan tertentu, bekerja dengan postur tidak nyaman dan lingkungan kerja kurang menyenangkan. Aspek metode kerja terkait postur duduk bersila, tidak ada SOP, durasi kerja berlebih. Penelitian ini menemukan keluhan pada pengrajin berupa pegal di: daerah punggung, pinggang, jari tangan dan kesemutan di kaki. Kesimpulan Sikap kerja dan layout merupakan aspek ergonomi yang paling dominan menimbulkan risiko bahaya ergonomi. Perlunya peningkatan pengetahuan masyarakat terkait ergonomi dan perancangan stasiun kerja yang ergonomis.
Faktor-Faktor yang Mempengaruhi Kenaikan Berat Badan Pada Pengguna Kontrasepsi Suntik di Wilayah Kerja Puskesmas Simpang IV Sipin Kota Jambi Tahun 2022
Authors: Afrilia Lisa , Fitri Adelina , Dhermawan Sitanggang Hendra , Mawarti Perdana Silvia , Wisudariani Evy 
Published: November 2024

Kontrasepsi suntik merupakan kontrasepsi hormonal yang efek sampingnya memicu nafsu makan dan meningkatkan berat badan. Kenaikan berat badan bisa terjadi dengan berbagai faktor seperti faktor internal yaitu genetik dan faktor eksternal yaitu aktivitas fisik, pola makan, lama pemakaian, usia, dll sehingga dalam penelitian ini peneliti memiliki tujuan yaitu untuk mengetahui faktor-faktor apa saja yang mempengaruhi kenaikan berat badan pada pengguna kontrasepsi suntik di wilayah kerja Puskesmas Simpang IV Sipin. Penelitian ini merupakan penelitian kuantitatif dengan desain cross sectional, menggunakan uji non parametrik uji Mann-Whitney SPSS. Pengambilan Sampel menggunakan Teknik simple random sampling jumlah sampel 77 orang, yaitu ibu yang menggunakan kontrasepsi suntik. Adanya pengaruh aktivitas fisik terhadap kenaikan berat badan pada pengguna kontrasepsi suntik p-value 0,0005, adanya pengaruh pola makan terhadap kenaikan berat badan pada pengguna kontrasepsi suntik p-value 0,0005, tidak adanya pengaruh lama pemakaian terhadap kenaikan berat badan pada pengguna kontrasepsi suntik p-value 0,697, adanya pengaruh usia terhadap kenaikan berat badan pada pengguna kontrasepsi suntik p-value 0,0005, adanya pengaruh penggunaan kontrasepsi suntik terhadap kenaikan berat badan p-value 0,023. Faktor yang mempengaruhi kenaikan berat badan pada pengguna kontrasepsi suntik yaitu aktivitas fisik, pola makan, usia, dan kontrasepsi suntik. Diharapkan responden dapat meningkatkan pengetahuan mengenai kontrasepsi suntik beserta efek sampingnya, sering melakukan aktivitas fisik seperti olahraga, dan mengatur pola makan.
De Ana Maria à Severina: o patrimônio cultural afetivo, as emoções e memórias em Ceilândia/DF
Authors: Zarbato Jaqueline Aparecida Martins , Rodrigues Sandra Maria 
Published: November 2024

O presente artigo parte do estudo da história das mulheres e também da Educação Patrimonial, seguindo as premissas do Patrimônio Cultural Afetivo, utilizando como ferramenta memórias femininas sobre a construção da então cidade-satélite de Ceilândia, zona periférica do Distrito Federal, e seus patrimônios culturais,institucionalizados e/ou afetivos ligados, em sua maioria, à construção da dignidade e cidadania de seus moradores, disponibilizadas pelo Arquivo Público do Distrito Federal - APDF. visa promover o conhecimento e a valorização do patrimônio cultural e história local analisando o papel desempenhado pelas mulheres como transmissoras de valores, conhecimentos e histórias na região administrativa de Ceilândia – DF. que se estabeleceu a partir de uma Campanha de Erradicação dos Invasores – CEI, trazendo análises e reflexões dos de Ana Maria, Antônia e Severia , visando contribuir com a visibilidade das memórias e histórias das mulheres e suas respectivas visões sobre a Ceilândia, visões e memórias carregadas de força e sensibilidade.
Plantas em trânsito
Authors: Chaves Larissa Patron , Macedo Mônica Lucas Leal de , Costa Rafael Ferreira 
Published: November 2024

Essa escrita trata da análise e reflexão sobre a circulação de plantas utilizadas para fins alimentícios e medicinais durante o Período Colonial no Brasil, entre os séculos XVI e XVII. Nosso objetivo é analisar a forma como esses produtos transitaram por esse território, e quais as conexões que se estabeleceram com os continentes europeu, africano, asiático, além dos demais territórios americanos, sejam pelo trabalho missionário ou pelas trocas comerciais com as metrópoles. O ponto de partida é observar como se obteve o reconhecimento dessas plantas e as suas relações com os seres humanos no período, para então compreender como ocorreram os seus deslocamentos intercontinentais até chegarem ao Brasil. Outro aspecto é refletir sobre como a biodiversidade brasileira fora construída a partir do estabelecimento desses espécimes, alargando o conhecimento sobre este e diferentes lugares do globo, e modificando as noções de local e global. Nessa perspectiva interessa-nos pensar os modos como esses itens alimentares ou curativos foram cultivados, pesquisados, explorados e consumidos para atender às necessidades dos diferentes contextos, perspectivando como a circulação contribuiu para a transformação de aspectos culturais em múltiplos territórios.
RISCO E MORTE EM O DIA: a dinâmica das narrativas de “abates” humanos em um jornal popular carioca
Authors: VENEGAS FERREIRA SORAYA , NUNES DE OLIVEIRA MALAFAIA DANIEL 
Published: November 2024

RESUMO
Para compreender como algumas narrativas jornalísticas sobre operações policiais publicadas em O Dia – um jornal carioca voltado ao público popular – caracterizam o risco e o medo na experiência social diante da morte ou de sua iminência, são analisadas duas coberturas de grande repercussão: o sequestro de um ônibus na ponte Rio-Niterói, em 2019; e a caçada a Lázaro Barbosa, em Goiás, em 2021. O que une os dois casos geograficamente distantes e de temporalidades distintas – o primeiro durou poucas horas e o segundo mais de 20 dias – é o “abate” dos criminosos por policiais, seguido por efusiva celebração da morte.

PALAVRAS-CHAVE: Medo; Risco de Morte; Jornalismo popular; Noticiário Policial; Jornal O Dia.