bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Impact of the Findings on Thin-Section Computed Tomography in stage I lung adenocarcinoma with visceral pleural invasion
Authors: Yuan Mei , Liu Jin-Yuan , Zhang Teng , Zhang Yu-Dong , Li Hai , Yu Tong-Fu 
Published: March 2018

AbstractVisceral pleural invasion (VPI) in stageI lung adenocarcinoma is an independent negative prognostic factor. However, no studies proved any morphologic pattern could be referred to as a prognostic factor. Thus, we aim to investigate the potential prognostic impact of VPI by extracting high-dimensional radiomics features on thin-section computed tomography (CT). A total of 327 surgically resected pathological-N0M0 lung adenocarcinoma 3 cm or less in size were evaluated. Radiomics signature was generated by calculating the contribution weight of each feature and validated using repeated leaving-one-out ten-fold cross-validation approach. The accuracy of proposed radiomics signature for predicting VPI achieved 90.5% with ROC analysis (AUC, 0.938, sensitivity, 90.6%, specificity, 93.2%, PPV: 91.2, NPV: 92.8). The cut-off value allowed separation of patients in the validation data into high-risk and low-risk groups with an odds ratio 12.01. Radiomics signature showed a concordance index of 0.895 and AIC value of 88.9% with regression analysis. Among these radiomics features, percentile 10%, wavEnLL_S_2, S_0_1_SumAverage represented as independent factors for determining VPI. Results suggested that radiomics signature on CT exhibited as an independent prognostic factor in discriminating VPI in lung adenocarcinoma and could potentially help to discriminate the prognosis difference in stage I lung adenocarcinoma.
Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet
Authors: Van Vrekhem S. , Vloebergh K. , Asadian M. , Vercruysse C. , Declercq H. , Van Tongel A. , De Wilde L. , De Geyter N. , Morent R. 
Published: March 2018

AbstractInsufficient glenoid fixation is one of the main reasons for failure in total shoulder arthroplasty. This is predominantly caused by the inert nature of the ultra-high molecular weight polyethylene (UHMWPE) used in the glenoid component of the implant, which makes it difficult to adhesively bind to bone cement or bone. Previous studies have shown that this adhesion can be ameliorated by changing the surface chemistry using plasma technology. An atmospheric pressure plasma jet is used to treat UHMWPE substrates and to modify their surface chemistry. The modifications are investigated using several surface analysis techniques. The adhesion with bone cement is assessed using pull-out tests while osteoblast adhesion and proliferation is also tested making use of several cell viability assays. Additionally, the treated samples are put in simulated body fluid and the resulting calcium phosphate (CaP) deposition is evaluated as a measure of the in vitro bioactivity of the samples. The results show that the plasma modifications result in incorporation of oxygen in the surface, which leads to a significant improved adhesion to bone cement, an enhanced osteoblast proliferation and a more pronounced CaP deposition. The plasma-treated surfaces are therefore promising to act as a shoulder implant.
Lack of impact of the El Hierro (Canary Islands) submarine volcanic eruption on the local phytoplankton community
Authors: Gómez-Letona M. , Arístegui J. , Ramos A. G. , Montero M. F. , Coca J. 
Published: March 2018

AbstractThe eruption of a submarine volcano south of El Hierro Island (Canary Islands) in October 2011 led to major physical and chemical changes in the local environment. Large amounts of nutrients were found at specific depths in the water column above the volcano associated with suboxic layers resulting from the oxidation of reduced chemical species expelled during the eruptive phase. It has been suggested that the fertilization with these compounds enabled the rapid restoration of the ecosystem in the marine reserve south of the island once the volcanic activity ceased, although no biological evidence for this has been provided yet. To test the biological fertilization hypothesis on the pelagic ecosystem, we studied the evolution and variability in chlorophyll a, from in situ and remote sensing data, combined with information on phytoplankton and bacterial community structure during and after the eruptive episode. Remote sensing and in situ data revealed that no phytoplankton bloom took place neither during nor after the eruptive episode. We hypothesize that the fertilization by the volcano did not have an effect in the phytoplankton community due to the strong dilution of macro- and micronutrients caused by the efficient renewal of ambient waters in the zone.
Adipokinetic hormone signaling determines dietary fatty acid preference through maintenance of hemolymph fatty acid composition in the cricket Gryllus bimaculatus
Authors: Fukumura Keisuke , Konuma Takahiro , Tsukamoto Yusuke , Nagata Shinji 
Published: March 2018

AbstractAdipokinetic hormone (AKH), an analog of mammalian glucagon, functions in supplying the required energy by releasing lipids and carbohydrates from the fat body into the hemolymph. Our previous study showed that AKH receptor (AKHR) knockdown in the two-spotted cricket Gryllus bimaculatus decreased hemolymph lipid levels and increased its feeding frequency. To reveal underlying mechanisms by which AKH signaling modulates lipid homeostasis, we analyzed the fatty acid composition as the lipid structure in the crickets. AKH administration significantly increased the proportion of unsaturated fatty acids (USFAs) to total fatty acids with decrease of the saturated fatty acids (SFAs) in hemolymph, while these proportions were inversely changed in RNA interference-mediated AKHR-knockdowned (AKHRRNAi) crickets. Interestingly, knockdown of hormone-sensitive lipase (Hsl) by RNAi (HslRNAi) affected the proportion of USFAs and SFAs in a similar manner to that observed in AKHRRNAi crickets. AKH administration in HslRNAi crickets did not change hemolymph fatty acid composition, indicating that AKH signaling critically altered fatty acid composition in the hemolymph through Hsl. In addition, a choice assay revealed that AKHRRNAi significantly increases the preference of USFAs. These data indicate that hemolymph lipid level and composition were modulated by AKH signaling with a complementary feeding behavior toward USFAs.
Pulmonary toxicity of exposure to nano nickel oxide
Authors: Chang Xuhong , Zhao Hongjun , Gao Jinxia , Chen Lijuan , Zhu An , Wang Cheng , Yu Shu , Ren Xiaolan , Ge Pengfei , Sun Yingbiao 
Published: March 2018

Many articles have been reported in the literature on the relationship between exposure to nano nickel oxide (NiO) and pulmonary toxicity, but no coherent results have been achieved. This research is aimed at investigating the combined toxicity effects of pulmonary induced by nano NiO using meta‐analysis. Data of cell and rat models were retrieved according to included and excluded criteria from 1994 to 2016. Twenty one articles were chosen in the meta‐analysis. The standardised mean difference between the exposure and control groups was calculated from the different endpoints in cell and rat models, respectively. The meta‐estimate was calculated using the computational equations when the effect size is measured in different scales. The results found that nano NiO induced the increasing of lactate dehydrogenase and decreasing of cell viability. We found an abnormal change in bronchoalveolar lavage fluid including the raised number of total cells, neutrophils, alveolar macrophage, and chemokines, as well as the transient increasing of pro‐inflammation cytokines. In addition, most of the above‐mentioned indicators can be changed after exposure to nano NiO from 1 week to 3 months and recovering at 6 months. Nano NiO could induce pulmonary toxicity, hinting potential adverse effect on the human respiratory system.
Imagerie globale de la Terre par les ondes sismiques
Authors: Romanowicz Barbara 
Published: March 2018

L’imagerie du manteau de la Terre est motivée par certaines questions fondamentales en géophysique, telle la compréhension des processus présents et passés de dynamique interne à l’origine de la tectonique des plaques.
Depuis une vingtaine d’années, l’étude de l’intérieur de la Terre connaît une véritable révolution, notamment grâce au développement de techniques toujours plus performantes de tomographie sismique et à la puissance de calcul rendue possible par l’informatique.
À l’heure actuelle, il est possible de calculer de manière précise le champ des ondes sismiques à travers des structures 3D arbitrairement complexes, en géométrie sphérique et pour des durées suffisantes, par des méthodes de calcul numérique, telle la méthode des « éléments spectraux ».
Anwendung der hyperthermen intrathorakalen Chemotherapie (HITHOC) in Deutschland
Authors: Ried Michael , Hofmann Hans-Stefan , Dienemann Hendrik , Eichhorn Martin 
Published: March 2018

Zusammenfassung
Hintergrund Die hypertherme intrathorakale Chemotherapie (HITHOC) wird seit mehreren Jahren an einigen thoraxchirurgischen Kliniken zusätzlich zur chirurgischen Zytoreduktion im Rahmen eines multimodalen Therapieansatzes zur Behandlung maligner Pleuratumoren angewendet. Genaue Zahlen zur HITHOC in Deutschland liegen bislang nicht vor.
Material und Methode Deutschlandweite schriftliche Umfrage an den thoraxchirurgischen Kliniken bzw. Abteilungen zu Anzahl, Indikationen, technischer Durchführung, perioperativen Schutzmaßnahmen und Komplikationen der HITHOC.
Ergebnis Insgesamt wurden 116 Kliniken angeschrieben. Die Rücklaufquote des Fragebogens lag bei 43% (n = 50). In 33 Kliniken wurde bisher keine HITHOC durchgeführt. Gründe hierfür sind mangelnde Ressourcen oder Erfahrung mit der HITHOC (n = 17), gefolgt von einer fehlenden Überzeugung bez. der Wirkung des Verfahrens (n = 8) verbunden mit einer zu hohen Komplikationsrate (n = 3). In 17 Kliniken wurden seit 2008 insgesamt 343 HITHOC-Prozeduren durchgeführt. Eine eigene Perfusionsmaschine besitzen 8 Kliniken, während sich die restlichen Kliniken die Maschine ausleihen. Indikationen stellten in allen Kliniken das maligne Pleuramesotheliom (n = 17), häufig Thymome mit pleuraler Aussaat (n = 11) und seltener die sekundäre Pleurakarzinose (n = 7) dar. Die HITHOC erfolgte in 16 Kliniken am geschlossenen Thorax, in den meisten Fällen bei 42 °C (n = 12) und für 60 Minuten (n = 15). Es wird immer Cisplatin entweder als Mono- (n = 9) oder in Kombinationstherapie (n = 8) verwendet. Alle Kliniken gaben als Ziel der HITHOC die Verbesserung der lokalen Tumorkontrolle sowie eine Verlängerung des rezidivfreien bzw. Gesamtüberlebens an. Über Komplikationen wird nur in wenigen Fällen berichtet.
Schlussfolgerung Die HITHOC wird derzeit an mindestens 17 Kliniken in Deutschland weitgehend standardisiert mit entsprechenden perioperativen Maßnahmen und ohne schwerwiegende Komplikationen durchgeführt. Ziel ist die Verbesserung der lokalen Tumorkontrolle bei bösartigen Neubildungen der Pleura und einer damit verbundenen Verbesserung der Überlebenszeit bei guter Lebensqualität.
Injuries in Austrian football players: Are they an issue?
Authors: Fischer Felix , Hoser Christian , Blank Cornelia , Schobersberger Wolfgang , Hepperger Caroline , Gföller Peter , Fink Christian 
Published: March 2018

Abstract
Purpose and Hypothesis With its load characteristics, the team sport of football places high physical demands on players and thus is associated with a high risk of injury. Therefore, the purpose of this study was to collect information about injuries suffered by football players in Austria during training or matches to enable participating clubs to learn about injuries.
Methods One hundred and forty-five players from seven teams with age ranging from 16 to 38 years participated in this prospective study during the 2015/16 season. Injury surveillance was conducted according to the consensus statement of Fuller et al. (2006).
Results During the period of study, a total of 83 injuries were recorded, which represents an overall incidence of 4.5 injuries/1000 hours (2.3 injuries/1000 hours in training and 14.2 injuries/1000 hours of match play). There was a significant difference for older age in injured players compared to non-injured players (p = 0.019). No differences in BMI were detected (p = 0.427). Ninety-four percent of all injuries occurred in the lower extremity, with the thigh (25.8 %), ankle (19.3 %) and knee (13.3 %) being the major locations of injuries. Muscle tendon injuries were the most common non-contact injuries (78.9 %).
Conclusion Lower extremity injuries are the most common injury in Austrian football. The incidence of muscle injuries is high, especially injuries of the posterior thigh. There are promising preventive strategies for the most common injury types. The implementation of these strategies is essential in order to reduce the incidence or recurrence of these football injuries.
Zweiter österreichischer Konsensus zur sicheren Anwendung von anti-TNF-α-Antikörpern bei chronisch-entzündlichen Darmerkrankungen
Authors: Miehsler Wolfgang , Dejaco Clemens , Gröchenig Hans-Peter , Fuchssteiner Harry , Högenauer Christoph , Kazemi-Shirazi Lili , Maier Harald , Mayer Andreas , Moschen Alexander , Reinisch Walter , Petritsch Wolfgang , Platzer Reingard , Steiner Pius , Tilg Herbert , Vogelsang Harald , Wenzl Heimo , Novacek Gottfried 
Published: March 2018

ZusammenfasungAnti-TNF-α-Antikörper haben die Therapie chronisch-entzündlicher Darmerkrankungen und anderer immunmediierter inflammatorischer Erkrankungen revolutioniert. Der zunehmende Einsatz dieser Substanzen war Anlass, den Konsensusbericht zur sicheren Anwendung von Infliximab der Arbeitsgruppe für Chronisch Entzündliche Darmerkrankungen der Österreichischen Gesellschaft für Gastroenterologie und Hepatologie aus dem Jahr 2010 zu aktualisieren und auf alle anti-TNF-α-Antikörper zu erweitern. Der vorliegende Konsensusbericht fasst die aktuelle Datenlage zur sicheren Anwendung von anti-TNF-α-Antikörpern zusammen und berücksichtigt folgende Themen: allgemeines Infektionsrisiko, bakterielle Infekte (inkl. Clostridium difficile, Tuberkulose, Nahrungsmittelhygiene), Pneumozystis jiroveci, virale Infektionen (inkl. Hepatitis B, Hepatitis C, HIV, CMV, VZV), Impfungen und Impfempfehlungen, gastrointestinale Aspekte (perianale Fistel, abdominale Fistel, Stenose), dermatologische Aspekte (Haut-Malignome, Ekzem-ähnliche anti-TNF-α-assoziierte Hautläsionen), Infusionsreaktionen und Immunogenität, demyelinisierende Erkrankungen, Hepatotoxizität, Hämatotoxizität, Herzinsuffizienz, Malignomrisiko und Einsatz nach Malignomen, sowie Schwangerschaft und Stillen. Da der Konsensusbericht als praktischer Leitfaden für die sichere Anwendung dieser Substanzen dienen soll, wurden die relevanten Aspekte in einer Checkliste zusammengefasst, die sich in zwei Teile „vor Therapie“ und „während Therapie“ gliedert.
Klinische Basisuntersuchung der Schulter
Authors: Friedrich Max , Wirtz Dieter , Rößler Philip 
Published: March 2018

Zusammenfassung
Zielsetzung Die erfolgreiche Behandlung von Schultererkrankungen erfordert eine exakte Diagnose. Neben einer differenzierten Anamneseerhebung stellt die klinische Untersuchung dabei den wichtigsten Bestandteil in der Diagnostik dar.
Methode Das vorliegende Video erklärt die gängigen Funktionsprüfungen und Provokationstests, die in der Basisuntersuchung der Schulter zum Einsatz kommen. Neben der Inspektion und Palpation liegt der Fokus hierbei auf den einzelnen Provokations- und Funktionstests.
Schlussfolgerung Der vorliegende Basisuntersuchungsgang ermöglicht eine strukturierte Herangehensweise an klinische Problemstellungen und kann, ergänzt um weitere spezifische und individuelle Tests, eine gute Grundlage für die Diagnostik von Schultererkrankungen darstellen.
Update Mammakarzinom 2017 – Etablierung neuer zielgerichteter Therapien
Authors: Lux Michael , Janni Wolfgang , Hartkopf Andreas , Nabieva Naiba , Taran Florin-Andrei , Overkamp Friedrich , Kolberg Hans-Christian , Hadji Peyman , Tesch Hans , Ettl Johannes , Huober Jens , Lüftner Diana , Wallwiener Markus , Müller Volkmar , Beckmann Matthias , Belleville Erik , Fehm Tanja , Wallwiener Diethelm , Brucker Sara , Schneeweiss Andreas , Fasching Peter 
Published: March 2018

ZusammenfassungIn den letzten Jahren sind zahlreiche neue Therapieoptionen für die Patientin mit einem Mammakarzinom in klinischen Studien entwickelt worden und teilweise zur Zulassung gekommen. Bei zunehmender Geschwindigkeit neuer Innovationen nimmt die Bedeutung von Kongressen zu, auf denen meist zum ersten Mal Daten zu den entsprechenden Therapien präsentiert werden. Diese Übersichtsarbeit greift Veröffentlichungen der Kongresse ASCO (American Society of Clincial Oncology) und ESMO (European Society of Medical Oncology) aus dem Jahr 2017 auf und fasst sie im Kontext bestehender Daten zusammen. Der Fokus liegt auf Erkenntnissen aus der neoadjuvanten Situation und Neuigkeiten aus der metastasierten Situation, wie dem Einsatz von CDK4/6-Inhibitoren oder PARP-Inhibitoren. Des Weiteren werden erste Ergebnisse zur Behandlung mit Checkpoint-Inhibitoren dargestellt. Bei baldigem Patentablauf von Trastuzumab sind zudem einige Studienergebnisse zu Trastuzumab-Biosimilars veröffentlicht worden. Auch die Digitalisierung der Patientenversorgung liefert erste Ergebnisse in Bezug auf Lebensqualität und Prognose von Patientinnen mit fortgeschrittener Krebserkrankung. Die digitale Kommunikation zwischen Patientin und Ärztin bzw. Arzt wird auch in Deutschland in einigen Studien untersucht. Bei anhaltender Diskussion über patientenrelevante Endpunkte für Patientinnen in der metastasierten Situation werden die Gesamtüberlebensdaten für die großen endokrin basierten Studien dringend erwartet. Erste Einblicke liefern vorläufige Analysen an kleinen Studienkollektiven. Im Rahmen der Patientenversorgung werden in den nächsten Jahren die Fragen aufkommen, welche Patientinnen besonders von bestimmten Therapien profitieren und welche vor besonders relevanten Nebenwirkungen geschützt werden können. Die Frage nach diesen Prädiktoren begleitet viele wissenschaftliche Projekte und bekommt eine besondere Aufmerksamkeit.
Psychophysical evidence for auditory motion parallax
Authors: Genzel Daria , Schutte Michael , Brimijoin W. Owen , MacNeilage Paul R. , Wiegrebe Lutz 
Published: March 2018

Significance
When we cannot see a sound source, it is very difficult to estimate how far away it is. In vision, motion parallax facilitates depth perception in that when we move, nearer objects move more in our visual field than farther objects. Our experiments show that humans can also exploit motion parallax for sound sources. Moreover, we show that, as in the visual system, facilitation of auditory depth perception is stronger when the subjects move actively than when subjects are being moved or when only the sound sources move. We conclude that dedicated mechanisms exist that integrate self-motion with binaural auditory motion cues, allowing humans to exploit auditory motion parallax.
Modeling recovery curves with application to prostatectomy
Authors: Wang Fulton , Rudin Cynthia , Mccormick Tyler H , Gore John L 
Published: March 2018

Summary
In many clinical settings, a patient outcome takes the form of a scalar time series with a recovery curve shape, which is characterized by a sharp drop due to a disruptive event (e.g., surgery) and subsequent monotonic smooth rise towards an asymptotic level not exceeding the pre-event value. We propose a Bayesian model that predicts recovery curves based on information available before the disruptive event. A recovery curve of interest is the quantified sexual function of prostate cancer patients after prostatectomy surgery. We illustrate the utility of our model as a pre-treatment medical decision aid, producing personalized predictions that are both interpretable and accurate. We uncover covariate relationships that agree with and supplement that in existing medical literature.
Biopanning data bank 2018: hugging next generation phage display
Authors: He Bifang , Jiang Lixu , Duan Yaocong , Chai Guoshi , Fang Yewei , Kang Juanjuan , Yu Min , Li Ning , Tang Zhongjie , Yao Pengcheng , Wu Pengcheng , Derda Ratmir , Huang Jian 
Published: March 2018

AbstractThe 2018 update of the biopanning data bank (BDB) stores phage display data sequenced by Sanger sequencing and next generation sequencing technologies. In this work, we upgraded the database with more biopanning data sets and several new features, including (i) incorporation of next generation biopanning data and the unselected population where the target is not determined and the round of screening is zero; (ii) addition of sequencing information; (iii) improvement of browsing and searching systems and 3 D chemical structure viewer; (iv) integration of standalone tools for target-unrelated peptides analysis within conventional phage display and next generation phage display (NGPD) data. In the current version of BDB (released on 19 January 2018), the database houses 3291 sets of biopanning data collected from 1540 published articles, including 95 NGPD data sets and 3196 traditional biopanning data sets. The BDB database serves as an important and comprehensive resource for developing peptide ligands.Database URL: The BDB database is available at http://immunet.cn/bdb
Almost Positive Curvature on an Irreducible Compact Rank 2 Symmetric Space
Authors: DeVito Jason , Nance Ezra 
Published: March 2018

Abstract
A Riemannian manifold is said to be almost positively curved if the set of points for which all two-planes have positive sectional curvature is open and dense. We show that the Grassmannian of oriented two-planes in $\mathbb{R}^{7}$ admits a metric of almost positive curvature, giving the first example of an almost positively curved metric on an irreducible compact symmetric space of rank greater than 1. The construction and verification rely on the Lie group $\mathbf{G}_{2}$ and the octonions, so do not obviously generalize to any other Grassmannians.
Down-Regulated Expression of Magnesium Transporter Genes Following a High Magnesium Diet Attenuates Sciatic Nerve Crush Injury
Authors: Chen Ying-Ju , Cheng Fu-Chou , Chen Chun-Jung , Su Hong-Lin , Sheu Meei-Ling , Sheehan Jason , Pan Hung-Chuan 
Published: March 2018

Abstract

BACKGROUND
Magnesium supplementation has potential for use in nerve regeneration. The expression of some magnesium transporter genes is reflective of the intracellular magnesium levels.

OBJECTIVE
To assess the expression of various magnesium transporter genes as they relate to neurological alterations in a sciatic nerve injury model.

METHODS
Sciatic nerve injury was induced in rats, which were then fed either basal or high magnesium diets. Magnesium concentrations and 5 magnesium transporter genes (SLC41A1, MAGT1, CNNM2, TRPM6, and TRPM7) were measured in the tissue samples.

RESULTS
The high magnesium diet attenuated cytoskeletal loss in a dose-dependent manner in isolated nerve explants. The high magnesium diet augmented nerve regeneration and led to the restoration of nerve structure, increased S-100, and neurofilaments. This increased regeneration was consistent with the improvement of neurobehavioral and electrophysiological assessment. The denervated muscle morphology was restored with the high magnesium diet, and that was also highly correlated with the increased expression of desmin and acetylcholine receptors in denervated muscle. The plasma magnesium levels were significantly elevated after the animals consumed a high magnesium diet and were reciprocally related to the down-regulation of CNNM2, MagT1, and SCL41A1 in the blood monocytes, nerves, and muscle tissues of the nerve crush injury model.

CONCLUSION
The increased plasma magnesium levels after consuming a high magnesium diet were highly correlated with the down-regulation of magnesium transporter genes in monocytes, nerves, and muscle tissues after sciatic nerve crush injury. The study findings suggest that there are beneficial effects of administering magnesium after a nerve injury.