bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating genetic counseling and testing in the pediatric oncology setting: Parental attitudes and influencing factors
Authors: Desrosiers Lauren R. , Quinn Emily , Cramer Stuart , Dobek Whitney 
Published: July 2019

AbstractBackgroundCancer predisposition syndromes (CPS) are caused by germline pathogenic variants that put an individual at increased risk of developing cancer throughout their lifetime. It is estimated that approximately 10‐15% of children with cancer have an underlying CPS. Although research has investigated the clinical utility of genetic testing for children diagnosed with cancer, this study aimed to gain a deeper understanding of parental attitudes toward genetic testing in this population.ProcedureAttitudes toward genetic counseling and testing among parents of children diagnosed with cancer were solicited through questionnaires distributed to a pediatric cancer clinic and online support groups. Quantitative data were analyzed using descriptive statistics and chi‐square tests for association.ResultsThe majority of participants had prior knowledge of genetic counseling (64.3%), yet most were not offered genetic counseling (59.5%). Fifty percent of parents reported interest in pursuing genetic counseling/testing and 31.0% reported uncertainty. Statistically significant associations were identified between interest in genetic counseling/testing and the child's age at diagnosis, child's sex, and participant annual income (P < .05).ConclusionsParents of children diagnosed with cancer generally expressed interest in genetic counseling/testing; however, notable uncertainty was also reported. In light of this uncertainty, genetic counselors have an ideal skill set to engage families in their decision‐making process as they weigh the benefits and drawbacks to pursuing genetic testing among this population. Demonstrated parental receptiveness to genomic technologies supports expansion of genetics providers in pediatric oncology care.
High incentive salience promotes motivation and pleasure experience
Authors: Zhang Yi‐Jing , Wang Jiao , Huang Jia , Chan Raymond C.K. 
Published: July 2019

AbstractThe present study aimed to examine the effect of incentive salience on the motivational behavior and pleasure experience of 35 healthy participants during reward pursuits. The findings suggest that high incentive salience promotes motivation in effort‐expenditure decision‐making, effort exertion, and pleasure experience.
Impact of pharmacy services on cystic fibrosis transmembrane conductance regulator modulator prescribing at a pediatric cystic fibrosis center
Authors: Wright Brittany A. , Singh Sachinkumar B. , Schultz Jordan L. , Ramsey Laura J. , Spading Kimberly A. , Mascardo Lisa A. , Starner Timothy D. 
Published: July 2019

AbstractBackgroundThis study was undertaken to determine if the presence of a clinical pharmacy team impacted patients’ access to cystic fibrosis transmembrane conductance regulator (CFTR) modulators.MethodsA retrospective chart review of electronic medical records from the University of Iowa Hospitals and Clinics (UIHC) was conducted. Data were collected regarding the timing of prior authorization (PA) submissions and approvals from 2012 to 2018. The Wilcoxon rank‐sum test was used to compare the meantime (days) between prescription and PA submission dates, and PA submission and approval date for all patients included in the analysis. Comparisons were made for pre‐ and postpharmacy services eras as well as the UIHC Specialty Pharmacy versus a non‐UIHC Specialty Pharmacy.ResultsSixty‐three patients were included in the final analysis. The average time between prescription date and PA submission was 12.5 days (standard deviation [SD] = 17.4 days) in the preclinical pharmacy services era and 3.5 days (SD = 5.8 days; P = .028) in the postclinical pharmacy services era. The average time to PA submission significantly decreased from 9.8 days (SD = 13.1 days) to 1.3 days (SD = 4.2 days; P < .0001) when prescriptions were filled by the UIHC Specialty Pharmacy vs a non‐UIHC Specialty Pharmacy.ConclusionsThere was a significant benefit to CFTR modulator prescribing when clinical pharmacy services were incorporated in our cystic fibrosis (CF) care team, which will become increasingly important with the anticipation of new CF medications in the near future.
Structural basis for −35 element recognition by σ4 chimera proteins and their interactions with PmrA response regulator
Authors: Lou Yuan‐Chao , Chou Chun‐Chi , Yeh Hsin‐Hong , Chien Chia‐Yu , Sadotra Sushant , Hsu Chun‐Hua , Chen Chinpan 
Published: July 2019

AbstractIn class II transcription activation, the transcription factor normally binds to the promoter near the −35 position and contacts the domain 4 of σ factors (σ4) to activate transcription. However, σ4 of σ70 appears to be poorly folded on its own. Here, by fusing σ4 with the RNA polymerase β‐flap‐tip‐helix, we constructed two σ4 chimera proteins, one from σ70 and another from σS of Klebsiella pneumoniae. The two chimera proteins well folded into a monomeric form with strong binding affinities for −35 element DNA. Determining the crystal structure of in complex with −35 element DNA revealed that adopts a similar structure as σ4 in the Escherichia coli RNA polymerase σS holoenzyme and recognizes −35 element DNA specifically by several conserved residues from the helix‐turn‐helix motif. By using nuclear magnetic resonance (NMR), was demonstrated to recognize −35 element DNA similar to . Carr‐Purcell‐Meiboom‐Gill relaxation dispersion analyses showed that the N‐terminal helix and the β‐flap‐tip‐helix of have a concurrent transient α‐helical structure and DNA binding reduced the slow dynamics on . Finally, only was shown to interact with the response regulator PmrA and its promoter DNA. The chimera proteins are capable of −35 element DNA recognition and can be used for study with transcription factors or other factors that interact with domain 4 of σ factors.
Ligand nanovectorization using graphene to target cellular death receptors of cancer cell
Authors: Arroyo Nicolas , Herlem Guillaume , Picaud Fabien 
Published: July 2019

AbstractTumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) is nowadays envisaged as a natural cytokine useful in nanomedicine to eradicate the cancer cells and not the healthy surrounding ones. However, it suffers from cell resistance and strong dispersion in body to prove its efficiency. The understanding at the molecular level of the TRAIL interaction with death receptors (DRs) on cancer cells is thus of fundamental importance to improve its action. We demonstrate here via molecular simulations that TRAIL can bind to its both agonistic DRs (ie, DR4 and DR5) with a preference for DR4. In this study, the role of a graphene nanoflake as a potential cargo for TRAIL is examined. Furthermore, both TRAIL self‐assembling and TRAIL affinity when adsorbed on graphene are considered to enhance efficacy toward the targeted cancer cell. Our modelization results show that TRAIL can bind to DR4 and DR5 when transported by graphene nanoflake, as a proof of concept.
Outliers detection using an iterative strategy for semi‐supervised learning
Authors: Frumosu Flavia D. , Kulahci Murat 
Published: July 2019

AbstractAs a direct consequence of production systems' digitalization, high‐frequency and high‐dimensional data has become more easily available. In terms of data analysis, latent structures‐based methods are often employed when analyzing multivariate and complex data. However, these methods are designed for supervised learning problems when sufficient labeled data are available. Particularly for fast production rates, quality characteristics data tend to be scarcer than available process data generated through multiple sensors and automated data collection schemes. One way to overcome the problem of scarce outputs is to employ semi‐supervised learning methods, which use both labeled and unlabeled data. It has been shown that it is advantageous to use a semi‐supervised approach in case of labeled data and unlabeled data coming from the same distribution. In real applications, there is a chance that unlabeled data contain outliers or even a drift in the process, which will affect the performance of the semi‐supervised methods. The research question addressed in this work is how to detect outliers in the unlabeled data set using the scarce labeled data set. An iterative strategy is proposed using a combined Hotelling's T2 and Q statistics and applied using a semi‐supervised principal component regression (SS‐PCR) approach on both simulated and real data sets.
δ15N analysis of ammonium in freeze‐dried natural groundwater samples by precipitation with sodium tetraphenylborate
Authors: Stock Patricia , Hösch Andreas , Burghardt Diana 
Published: July 2019

RationaleTo perform the δ15N isotopic analysis of ammonium (NH4+) with an elemental analyzer (EA) coupled to an isotope‐ratio mass spectrometer, it is necessary to isolate the NH4+ prior to the analysis. Existing methods are work‐intensive and time‐consuming. For broader applicability in the environmental sciences, it is desirable to simplify the sample preparation process. The method used here is based on the insolubility of ammonium tetraphenylborate ((C6H5)4BNH4) in water. Its suitability for the stable isotope measurement of δ15N values for NH4+ has already been proven (Howa et al. Rapid Commun Mass Spectrom. 2014;28:1530‐1534). However, there are no studies on the usability of the method for the analysis of ammonium‐containing water samples. In this study, the method was tested for its applicability to natural groundwater samples.MethodsTo achieve the necessary high NH4+ concentrations for complete (C6H5)4BNH4 precipitation, the water samples were first freeze‐dried and then prepared for the analysis. To precipitate the NH4+, sodium tetraphenylborate ((C6H5)4BNa) was added to the samples. The precipitate was then separated from the water by filtration using a membrane filter and analyzed using an EA interfaced with an isotope ratio mass spectrometer to determine the nitrogen isotope ratio.ResultsA consistent 15N enrichment of +0.65‰ was found in the measured isotope ratios. No significant effect due to other ions in the water samples could be identified. There was no significant difference between the isotope ratios of the natural groundwater samples determined from the tetraphenylborate (TPB) method and those determined from the diffusion method (DM). This indicates that the TPB method can easily be used for natural groundwater samples.ConclusionsThe TPB method in combination with freeze‐drying is an efficient technique for the precise δ15N measurement of NH4+ in natural groundwater samples. The laboratory effort required for sample preparation is very low, and the repeatability of the measurements is very high.
On time‐varying formation feasibility and reference function of time‐delayed linear multiagent systems with switching digraphs
Authors: Dong Xiwang , Hua Yongzhao , Hu Guoqiang , Li Qingdong , Ren Zhang 
Published: July 2019

SummaryTime‐varying formation feasibility and formation reference function of linear multiagent systems with both time‐varying delays and switching directed topologies are studied. For a given linear multiagent system, not all the time‐varying formations can be realized due to the dynamic restriction of each agent. The formation feasibility constraint reveals the requirement on the desired time‐varying formation to be compatible with the agent dynamics. Formation reference is a representation for the macroscopic movement of the whole multiagent system. Novel features of the formation feasibility constraint and the formation reference are the main focus of this paper. Firstly, a time‐delayed formation control protocol with switching directed topologies is constructed using local neighboring information. Then, a time‐varying formation feasibility constraint is derived based on nonsingular transformations. It is proven that the time‐varying formation feasibility constraint is independent of the time‐varying delays and the switching directed topologies. Moreover, an explicit expression of the formation reference function is proposed. It is shown that neither the time‐varying delays nor the switching directed topologies has influence on the obtained formation reference function. Finally, comparative examples are provided to demonstrate the obtained results.
Distribution of Botia superciliaris (Günther, 1892) ichthyoplankton in the upper mainstem of the Yangtze River preimpoundment and postimpoundment of the upstream dam cascade
Authors: Wang Zhen , Cheng Fei , Hou Gang , Song Yiqing , Thundiparambil Sathrajith Arunjith , Xie Songguang 
Published: July 2019

AbstractDam cascades have been a major threat to fishes of the upper Yangtze River. The remaining lotic river segment of the upper mainstem between the Xiangjiaba Dam (XJD) and the Three Gorges Reservoir (TGR) may serve as a critical refuge for endemic fishes. We investigated distribution of ichthyoplankton Botia superciliaris, an endemic species, at three sections preimpoundment and postimpoundment of the XJD, that is, Yibin (close to the XJD), Zhuyang (in the middle of the segment), and Mudong (in the tail of the TGR). Preimpoundment of the XJD, larvae occurred in all three sections, and their abundance tended to be highest at Yibin and lowest at Mudong. Postimpoundment, larval abundance dramatically decreased in all three sections. In particular, no larvae were found at Yibin, and larval abundance tended to be higher at Zhuyang than at Mudong. Eggs were collected from all three sections, and those from Zhuyang accounted for over 90% of the total. Initiation of egg occurrence at Yibin was approximately 1 month later than at Zhuyang and Mudong. Water temperature was lower, and water transparency was higher at Yibin than at Zhuyang and Mudong postimpoundment. We suggest that the decrease in abundance and delayed presence of ichthyoplankton at Yibin postimpoundment of the XJD reflected the impact of upstream dam discharge and that the lower abundance of ichthyoplankton at Mudong compared with Zhuyang both preimpoundment and postimpoundment of the XJD reflected the influence of inundation by the TGR. We recommend that the river sections around Zhuyang become high‐priority conservation areas
Lowland stream restoration by sand addition: Impact, recovery, and beneficial effects on benthic invertebrates
Authors: dos Reis Oliveira Paula C. , Kraak Michiel H.S. , Verdonschot Piet F.M. , Verdonschot Ralf C.M. 
Published: July 2019

AbstractUp to now, most lowland stream restoration projects were unsuccessful in terms of ecological recovery. Aiming to improve the success of stream restoration projects, a novel approach to restore sandy‐bottom lowland streams degraded by channel incision was launched, consisting of the addition of sand to the stream channel in combination with the introduction of coarse woody debris. Yet it remained unknown whether this novel measure of sand addition is actually effective in terms of biodiversity improvements. The aim of the present study was therefore to evaluate if sand addition can improve hydromorphological stream complexity on the short term leading to an increase in macroinvertebrate biodiversity. To this end, particle transport, water depth, current velocity, dissolved oxygen dynamics, and sediment composition were measured. The response of the macroinvertebrate community composition was determined at different stages during the disturbance and short‐term recovery process. Immediately downstream the sand addition site, transport and sedimentation of the sand were initially intense, until an equilibrium was reached and the physical conditions stabilized. The stream section matured fast as habitat formation took place within a short term. Macroinvertebrate diversity decreased initially but recovered rapidly following stabilization. Moreover, an increase in rheophilic taxa was observed in the newly formed habitats. Thus, although sand addition initially disturbed the stream, a relatively fast physical and biological recovery occurred, leading to improved instream conditions for a diverse macroinvertebrate community, including rheophilic taxa. Therefore, we concluded that sand addition is a promising restoration measure for incised lowland streams.
Designed Construction of Hierarchical CuCo2S4@Co(OH)2 Core‐Shell Nanoarrays as Electrode Materials for High‐Performance Supercapacitors
Authors: Sun Xueying , Sun Xiulun , Zhou Sicheng , Luo Guang , Liu Rongmei , Li Siqi , Li Anran , Zhu Xiandong 
Published: July 2019

AbstractIn this paper, a novel three‐dimensional (3D) hierarchical structure of CuCo2S4@Co(OH)2 core‐shell hybrid electrode was reported. It uses self‐supporting nanoneedles CuCo2S4 without organic binders synthesized by hydrothermal method as ideal conductive supports for Co(OH)2 nanosheets. The prepared CuCo2S4@Co(OH)2 composite electrode has good electrochemical performance with a specific capacitance of 2066 F⋅g−1 at 1 A⋅g−1 (highest specific capacity of 258 mAh⋅g−1) and a high capacitance retention rate (over 82.76% at 10 A⋅g−1 after 1000 cycles). The asymmetric supercapacitor device (CuCo2S4@Co(OH)2//AC) has an energy density of 37.58 Wh⋅kg−1 at 795.8 W⋅kg−1, and a high capacitance retention rate over 84.10% after 5000 cycles at 10 A⋅g−1, which exhibits the enormous potential of this hybrid nanostructure as high performance supercapacitor electrode material.
Water‐Mediated, Highly‐Efficient and Improved Protocol for the Synthesis of Vesamicol, Its Analogues and β‐Blockers through the Highly‐Chemoselective Aminolysis of Epoxides
Authors: Agarwal Jyoti , Peddinti Rama Krishna 
Published: July 2019

AbstractAn efficient, eco‐friendly and cost‐effective protocol has been developed for the synthesis of vesamicol, benzovesamicol, spirovesamicol, their analogues and drug molecules such as Naftopidil and SR 59230 A. In this reaction, water has played dual role i. e. of i) bifunctional catalyst and ii) reaction medium. Except reactants, no other chemical reagent/promotor is required to afford the products. Reaction follows 100% atom economy and has been found to be highly chemo‐selective. All studied reactions worked well to yield the corresponding products in excellent to near quantitative yields without following the tedious and time consuming column chromatography as purification step. Thus, this protocol provides the vesamicol and other products without generating any chemical waste to the environment. Furthermore, this methodology has been successfully applied for 15 gm scale also.
New Cobalt(II) and Copper(II) Thiocyanate Complexes of 2,5‐Bis(pyridin‐2‐yl)‐1,3,4‐oxadiazole Ligand: Synthesis, Crystal Structures, Spectral Properties and Hirshfeld Surface Analysis
Authors: Rhoufal Ferdaousse , Laachir Abdelhakim , Guesmi Salaheddine , Jouffret Laurent , Sergent Nicolas , Obbade Saïd , Akkurt Mehmet , Bentiss Fouad 
Published: July 2019

AbstractThe synthesis and characterization of two new mononuclear coordination complexes based on 2,5‐bis(pyridin‐2‐yl)‐1,3,4‐oxadiazole (bpox) and thiocyanate ion as coligand, [M(bpox)2(SCN)2]nH2O (M=Co, n=1 for complex 1; M=Cu, n=0 for complex 2), are described. The obtained complexes crystallize in the monoclinic crystal system with space group C 2/c for complex 1 and P 21/n for complex 2. UV/Vis, FTIR and Raman data indicated the presence of bpox and thiocyanate groups, in isolated compounds. This finding has been confirmed by crystallographic studies, which shows that the two metals Co(II) and Cu(II), have an octahedral environment in complex 1 and complex 2, respectively, with both bpox ligands in equatorial sites and terminal SCN− in axial positions. The crystal structure cohesion of each compound is ensured by intramolecular metal‐nitrogen M–N (M= Co, Cu) interactions, by π–π stacking interactions and by different intermolecular‐hydrogen bonds, such as C–H⋯π, O–H⋯N, O–H⋯O, C–H⋯N, and/or C–H⋯S. The three‐dimensional Hirshfeld surface analysis and the two‐dimensional fingerprint plots reveal that the structure is dominated by C⋯H/H⋯C contacts.
Iron, Cobalt, and Nitrogen Tri‐Doped Ordered Mesoporous Carbon as a Highly Efficient Electrocatalyst for Oxygen Reduction Reaction
Authors: Ran Wu , Dong Jing , Sun Tingting , Chen Jianfeng , Xu Lianbin 
Published: July 2019

AbstractMany heteroatom‐doped carbon materials have recently been fabricated to enhance the electrocatalytic oxygen reduction reaction (ORR) performance as promising alternatives to the scarce and high cost Pt‐based catalysts. Herein, Fe, Co, N‐tri‐doped ordered mesoporous carbon materials (Fe‐Co−N‐OMCs) are synthesized by a facile templating technique using ordered close‐packed silica nanospheres as a hard template and ferric chloride hexahydrate (FeCl3⋅6H2O), cobalt chloride hexahydrate (CoCl2⋅6H2O), dicyandiamide (DCDA), and sucrose as Fe, Co, N and C source, respectively. This method can be easily extended to synthesize a variety of doped carbon‐based materials containing ordered mesopores. The results show that the bimetallic doping in this carbon‐based materials is more favorable than single metal doping in catalyzing the ORR process. The best performing catalyst (Fe‐Co−N‐OMC (1:1)) exhibits comparable ORR activity with a half‐wave potential of 0.83 V vs. reversible hydrogen electrode (RHE) and superior stability to the commercial 20 wt% Pt/C in alkaline medium. The enhanced ORR performance of Fe‐Co−N‐OMC (1:1) could be attributed to the tri‐doping of Fe, Co and N into the carbon skeleton for catalytic reactions and the ordered mesoporous structure for facile mass transport and more exposed active sites.
A Novel Protective Strategy on High‐Voltage LiCoO2 Cathode for Fast Charging Applications: Li1.6Mg1.6Sn2.8O8 Double Layer Structure via SnO2 Surface Modification
Authors: Wang Mengcheng , Feng Xuyong , Xiang Hongfa , Feng Yuezhan , Qin Changdong , Yan Pengfei , Yu Yan 
Published: July 2019

AbstractSurface corrosion from electrolyte and reconstruction of layer‐structure LiCoO2 are the most important reasons for capacity decay and charging kinetics limitation. Spinel‐type material forms on the surface of LiCoO2 after cycling, which is more stable than the layer‐structure. To stabilize the surface and suppress the reconstruction, double layer structure Li1.6Mg1.6Sn2.8O8 matching LiCoO2 well is introduced to protect Mg‐doped LiCoO2 and restrain the structure change. With a simple surface coating of SnO2 and further high temperature treatment, Mg2+ in LiCoO2 and partly Li+ are extracted out and reacted with SnO2 to form double layer Li1.6Mg1.6Sn2.8O8. Meanwhile, Co3+ in pristine LiCoO2 is partly oxidized and electronic conductivity enhanced after surface modification. The Li1.6Mg1.6Sn2.8O8 coating efficiently stabilizes the surface structure of LiCoO2, with less structure change, less cracks appearing on the surface, and much better cycling performance. In addition, stable surface and higher electronic conductivity of LiCoO2 lead to better rate performance.