bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of ionic transport processes in a model of arterial hypertension
Authors: Nosarev A. V. , Birulina Yu. G. , Petrova I. V. , Kovalev I. V. , Gusakova S. V. , Smagliy L. V. , Teslya E. S. , Shamanaev A. Yu. , Pushkina E. V. , Medvedev M. A. 
Published: January 2019

Aim.To study the ionic mechanisms which underlie regulation contractile activity of vascular smooth muscles and the erythrocytes membrane potential from spontaneously hypertensive rats.Materials and methods.The effect of acetylcholine (ACX), 10 μM, and Ca2+ -ionophore A23187, 10 μM, on the contractile reactions of isolated smooth muscle segments of the aorta from 11-week-old spontaneously hypertensive rats (SHR) and Wistar – Kyoto rats (WKY) induced by phenylephrine (PE), 1 μM, was measured by the mechanography. 11-week-old SHR were divided into control and experimental groups depending on the drug administration (amlodipine 10 mg/kg given intragastrically). Blood pressure (BP) in SHR was measured before and after treatment. The amplitude of the hyperpolarizating response (HO) and the activity of Ca2+-dependent K+-channels of the erythrocyte membrane of SHR were performed with potentiometric method.Results.In response to the stimulating effect of the ACX or the calcium ionophore A23187, the smooth muscle segments of the aorta from the WKY and SHR precontracted with PE were relaxed. To the addition of the ACX, the vascular segments of the SHR responded with a stronger dilatation than the WKY segments, but not the action of the Ca2+-ionophore. Treatment of SHR with blocker of Ca2+-channels of L-type amlodipine caused a decrease the BP, and an increase in the relaxing effect of intact aortic segments on the ACX and Ca2+-ionophore. There was an increase the amplitude of HO and activity of Ca2+-dependent K+-channels of the erythrocyte membrane from SHR.Conclusion.Relaxation of vascular smooth muscle in SHR is caused by changes in the endothelial function and Ca2+-dependent ionic conductivity of the myocyte membrane. An increase of the hyperpolarizating response of the erythrocyte membrane from rats with spontaneous hypertension is associated with activation of potassium channels. The selective effect on these intracellular targets can serve as a basis for the development of antihypertensive drugs.
A multi-centre study on the role of the thioredoxin system in breast cancer cell proliferation
Authors: Shakhristova E. V. , Stepovaya E. A. , Nosareva O. L. , Litvinova L. S. , Skuratovskaya D. A. , Rudikov E. V. , Sadykova A. A. , Novitsky V. V. 
Published: January 2019

Redox proteins (thioredoxin, glutaredoxin) are key macromolecules capable of modulating intracellular processes. This determines research choices in the field of redox-dependent cell proliferation management. The study of the molecular mechanisms of the onset, development and progression of malignant neoplasms underlies the search for tumor-associated markers and potential targets for personalized antitumor therapy.Purpose.To establish the role of the “thioredoxin – thioredoxin-reductase” system in the impaired proliferation of mammary adenocarcinoma cells under the action of the cyclin-dependent protein kinase roskovitin blocker.Materials and methods.The study was carried out using the culture of mammary adenocarcinoma cells of the MCF-7 line incubated in the presence and absence of roskovitin at a final concentration of 20 μM for 18 h. The intracellular content of thioredoxin and protein regulators of proliferation (cyclin E and cyclin-dependent protein kinase 2) were determined by Western blotting technique, the expression level of thioredoxin mRNA was determined by real-time polymerase chain reaction and the activity of thioredoxin-reductase was measured by a spectrophotometric method.Results.It was established that the decrease in proliferative activity of MCF-7 tumor cells incubated in the presence of roskovitin was accompanied by a decrease in the content of cyclin E and cyclin-dependent kinase on the background of a decrease in the expression level of thioredoxin mRNA and an increase in the activity of thioredoxin-reductase.Conclusion.The involvement of the components of the thioredoxin system (thioredoxin, thioredoxinreductase) in disrupting the proliferation of MCF-7 tumor cells was detected under the action of the cyclindependent protein kinases of roskovitin.
Remodeling of the common carotid artery in oncohematological pathology by ultrasound
Authors: Koptev V. D. , Nimaev V. V. , Gorchakov V. N. 
Published: January 2019

The aimis the assessment of structural and functional state of common carotid artery by ultrasound in patients with non-Hodgkin malignant lymphomas (NHML) before and after chemotherapy.Materials and methods.The common carotid artery of 111 patients at different stages of NHML were examined via a “LOGIC 400” ultrasound.Results.The common carotid artery of patients with NHML is undergoing morphological modification with changes in thickness and diameter, which corresponds to a hypertrophic type of remodeling. There is an increase in the thickness of the complex “intima-media” and Kernogan`s index with decreasing the common carotid artery diameter by comparison with the control group. Chemotherapy improves the parameters of the common carotid artery while reducing the thickness of the complex “intima-media” and Kernogan`s index at different stages of NHML.Conclusion.Remodeling of the common carotid artery is associated with the developmental stage of NHML. Chemotherapy leads to an improvement of the morphological parameters of the common carotid artery, which evaluates the effect of the treatment.
The study of the Crataegus sanguinea Pall. extractsdiuretic and antidepressant action
Authors: Kurkin V. A. , Zaitceva E. N. , Morozova T. V. , Pravdivtseva O. E. , Dubishchev A. V. , Kurkina A. V. , Avdeeva E. V. , Agapov A. I. , Belousov M. V. 
Published: January 2019

The purposeof the study is to study the urinative and antidepressant activities of liquid extracts based on flowers, shoots, leaves and fruits ofCrataegus sanguineaPall. to substantiate their use in the development and manufacture of drugs for the complex treatment of cardiovascular diseases.Materials and methods.The comparative study of the diuretic and antidepressant activity of liquid extracts based on leaves, flowers, shoots and fruits Crataegus sanguinea was conducted. The liquid extracts were obtained on the basis of dried leaves, flowers, shoots and fruits of Crataegus sanguinea. All liquid extracts were obtained in the ratio “raw – extractant” 1 : 1, in all cases the extracting agent was ethyl alcohol 70%. The studies were conducted using outbred white rats of both sexes. All preparations were examined in a dose of 100 μl/kg. The diuretic activity of Crataegus sanguineaof liquid extracts in chronic experiments was determined, 4 h and 24 h portions of urine were collected. The antidepressant activity was tested using the “Desperation” testResults.During the experiment, the diuretic activity of the liquid extract Crataegus sanguinea, as well as the antidepressant activity of liquid extracts of Crataegus sanguinea, shoots and fruits were revealed. Conclusion. Crataegus sanguinea preparations have complex nephrotropic and neurotropic action and can be recommended for use in the cardiovascular pathology treatment.
The effect of preventive use of corticosteroids on postoperative complications after esophagectomy: A retrospective cohort study
Authors: Jeong Heejoon , Choi Ji Won , Ahn Hyun Joo , Kim Jie Ae , Yang Mikyung , Kim Jin Kyoung , Park Mihye , Kim Duk Kyung , Shin Byung Seop , Lee Sang Hyun , Kim Young Ri , Chung Yoon Joo 
Published: January 2019

Abstract
Background: Although corticosteroids were known to reduce acute respiratory distress syndrome (ARDS) after esophagectomy, the efficacy of corticosteroid remains debatable. Moreover, the risk of anastomosis leakage or infection, which relates to the administration of corticosteroid is another concern. Therefore, we compared the incidence of composite complications between patients who received or not the preventive administration of corticosteroid in esophagectomy.
Methods: All patients who underwent esophagectomy from 2010 to 2015 at a tertiary care university hospital, were reviewed in this retrospective study (n=1,041). Patients were divided into Steroid (n=120) and Control (n=860) groups based on the preventive administration of corticosteroid during surgery. The primary endpoint was the incidence of composite complications (acute respiratory distress syndrome, wound dehiscence, and infection). Comparison between the two groups was performed after adjustment of co-variables.
Results: The incidence of composite complications was not different between Steroid and Control group (21.7% vs 17.4%, respectively; P=0.26). Incidence of complications in each category between Steroid and Control groups were not significantly different: acute respiratory distress syndrome (5.0% vs 3.8%; P=0.46), graft dehiscence (6.7% vs 4.8%; P=0.37), and infection (15.8% vs 12.8%; P=0.36). After propensity score matching, the difference between the groups was also not significant. In multivariable analysis, age, lower body mass index, diabetes mellitus and duration of operation were independent risk factors of composite complications. Additionally, intraoperative vasopressor was a risk factor of graft dehiscence (odds ratio, 2.06; 95% confidence interval, 1.03-4.12; P=0.0407).
Conclusions: The preventive use of corticosteroid was not related to the incidence of composite complications after esophagectomy. Application of corticosteroid for prevention of acute respiratory distress syndrome is not recommended due to its lack of apparent benefit.
Keywords: Acute respiratory distress syndrome, corticosteroid, esophagectomy.
EVALUATION OF THE NATURAL RECREATION SYSTEM OF THE PERM REGION
Authors: Korolev Andrey Yu. , Safarian Azat A. 
Published: January 2019

In this paper we suggest a formula to evaluate the recreational possibilities of natural recreational systems (NRS). The formula depends on economic activity, accessibility, climate, relief and landscape attraction of unsettled territories. Unsettled territories are consisted with unpopulated areals with different scales and at the most remote points from any infrastructure, the center of unpopulated areals are situated. The aggregate of these unpopulated areas constitutes a natural recreational system - a natural area slightly modified by human economic activities in which recreation can be still carried out.The formula will allow choosing natural fit territories to develop recreational and tourist activities and create protected natural areas. Evaluation of the Perm region natural recreational system was conducted with the help of this formula. As a result, a map of the Perm region was portrayed on which there are some separate sections of similar NRS qualities. Most part of the region (48%) is at the average level of NRS quality. Only the north-eastern and a few particular sites on hills not affected by economic activities, are up to a high quality level (5%). None of the Perm region reaches the maximum score, due to climate severity and inability to fully use the territory for touristic activities throughout the whole year.
The Predictive Maintenance Concept in the Maintenance Department of the “Industry 4.0” Production Enterprise
Authors: Tran Anh Duc , Dąbrowski Karol , Skrzypek Katarzyna 
Published: January 2019

Abstract
Modern technical environments require a high degree of reliability both in machinery and in equipment. Technological progress has, on the one hand, increased this efficiency but on the other hand, it has changed the way in which this equipment and these machines have traditionally been maintained. The authors have set the following assumptions. In order to survive in the market and develop, modern production enterprises realize the assumptions of Industry 4.0, wherein the optimization of maintenance processes is important because of the financial situation. This includes the profits made by the production company and differs from traditional maintenance, by shifting towards new trends such as predictive maintenance; as such, it is crucial for the development of the company. The article is devoted to the most modern predictive maintenance strategy, in the maintenance department of a manufacturing company. The publication describes the meaning of the method, its potential and the theory of action.
Hubungan Kepatuhan Minum Obat Antihipertensi Terhadap Tercapainya Target Terapi Pasien Hipertensi di Puskesmas Wirobrajan Yogyakarta
Authors: Cahyani Fani Mardina 
Published: January 2019

<p><em> Center for Health Data and Information (Pusdatin) Province of Yogyakarta (DIY) 2016 based on Riskesdas 2013, DIY province with hypertension prevalence 12,8% rank 3 in Indonesia after North Sulawesi and South Kalimantan. The case data of family visits, hypertension disease has become the second most dominant disease for family groups in DIY. The top ten diseases diagnosed in outpatients in Puskesmas according to the report of integrated surveillance system, hypertension became the third order after diarrhea and influenza case. The purpose of this study was to determine the relation of adherence to antihypertensive medication to the achievement of hypertension therapy target at Wirobrajan Health Center Yogyakarta. This research is a type of observational research with cross sectional method. Method of sampling with total population with inclusion criteria that visit to Wirobrajan Health Center. The sample in this study were 50 patients. Primary data collection was conducted using MMAS questionnaire. The result of chi-square test between adherence level and the achievement of therapeutic target that is p value 0,005 &lt;0,05 this indicates the relation between adherence level with the achievement of therapy target.</em></p><p><em>Keywords: adherence, hypertension, therapeutic target</em></p>
TA Treatment of Depression: A Hermeneutic Single-Case Efficacy Design Study - 'Sergio'
Authors: Benelli Enrico , Gentilesca Giulia , Boschetti Désirée , Piccirillo Cristina , Calvo Vincenzo , Mannarini Stefania , Palmieri Arianna , Zanchetta Mariavittoria 
Published: January 2019

This study is the fifth of a series of seven and belongs to the second Italian systematic replication of findings from previous series that investigatedthe effectiveness of a manualized Transactional Analysistreatment for depression through Hermeneutic Single-Case Efficacy Design.The therapist was a white Italian woman with 5years of clinical experience and the patient, Sergio, was a 39-year old white Italian man who attended sixteen sessions of transactional analysis psychotherapy. Sergio satisfied DSM 5 criteria for Persistent Depressive Disorder (Dysthymia) with melancholic features, Post-Traumatic Stress Disorder (PTSD) with Obsessive Personality traits. The treatment focused on the permission to enjoy and on self-protection. The focus on both depressive symptoms and obsessive traits allowed a remission of his dysthymia within the end of therapy. The judges evaluated the case as a good outcome: the depressive and anxious symptomatology clinically and reliably improved over the course of the therapy and these improvements weremaintained at the followups. Furthermore, the patient reported significant change in his post-treatment interview and these changes were directly attributed to the therapy.
Citation - APA format:
Benelli, E., Gentilesca, G., Boschetti, D., Piccirillo, C., Calvo, V., Mannarini, S., Palmieri, A. and Zanchetta, M. (2018). TA Treatment of Depression: A Hermeneutic Single-Case Efficacy Design Study - Sergio. International Journal of Transactional Analysis Research & Practice, 9(2), 23-41 https://doi.org/10.29044/v9i2p23
TA Treatment of Depression: A Hermeneutic Single-Case Efficacy Design Study - 'Beatrice'
Authors: Benelli Enrico , Vulpiani Francesca , Cavallero Giorgio Cristiano , Calvo Vincenzo , Mannarini Stefania , Palmieri Arianna , Zanchetta Mariavittoria 
Published: January 2019

This study is the sixth of a series of seven and belongs to the second Italian systematic replication of findings from previous series that investigatedthe effectiveness of a manualized transactional analysistreatment for depressionthrough Hermeneutic Single-Case Efficacy Design.The therapist was a white Italian woman with 10 years of clinical experience and the patient, Beatrice, was a 45-year old white Italian woman who attended sixteen sessions of transactional analysis psychotherapy. Beatrice satisfied DSM 5 criteria for Major Depressive Disorder, Anxious Distress, with Dependent and Histrionic Personality Traits. The judges evaluated the case as a good outcome: the depressive and anxious symptomatology clinically and reliably improved over the course of the therapy and these improvements weremaintained throughoutthe duration of thefollowup intervals. Furthermore, the patient reported significant change in her post-treatment interview and these changes were directly attributed to the therapy.
Citation - APA format:
Benelli, E., Vulpiani, F., Cavallero, G., Calvo, V., Mannarini, S., Palmieri, A. and Zanchetta, M. (2018). TA Treatment of Depression: A Hermeneutic Single-Case Efficacy Design Study - Beatrice. International Journal of Transactional Analysis Research & Practice, 9(2), 42-63 https://doi.org/10.29044/v9i2p42
Taxonomic review of the tribe Nymphalini (Lepidoptera: Nymphalidae: Nymphalinae) from western Himalaya, India with special emphasis on external genitalic attributes
Authors: Mehra Deepika , Kirti Jagbir Singh , Sidhu Avtar Kaur 
Published: January 2019

Taxonomic review for 11 species referable to six genera under the tribe Nymphalini has been presented. Taxonomic characterization, and elucidation of external genitalic attributes, has been done for five species namely, Nymphalis xanthomelas (Esper), Polygonia c-album (Linnaeus), Kaniska canace (Linnaeus), Symbrenthia lilaea (Hewitson) and Symbrenthia hypselis (Godart) from western Himalaya, India. Along with that, distribution and taxonomic remarks on species Symbrenthia niphanda Moore and Symbrenthia brabira Moore, and species under genera Aglais Dalman and Vanessa Fabricius from the western Himalaya has been discussed from the older literature. Major gaps in the taxonomic history of the tribe Nymphalini has been mentioned in the concluding remarks.
RETRACTED: Plumbagin Ameliorates Collagen-Induced Arthritis by Regulating Treg/Th17 Cell Imbalances and Suppressing Osteoclastogenesis
Authors: Wang Tingyu , Qiao Han , Zhai Zanjing , Zhang Jun , Tu Jinwen , Zheng Xinyi , Qian Niandong , Zhou Hong , Lu Eryi , Tang Tingting 
Published: January 2019

Objective: Plumbago zeylanica L. (with plumbagin as its active ingredients) has been used for centuries to treat conditions such as joint swelling, fractures, and bacterial infections, suggesting that it possesses anti-inflammatory and immunosuppressive properties. In the present study, we evaluated the potential anti-arthritic activity and related mechanisms of plumbagin.Methods: Collagen-induced arthritis (CIA) was initiated in Wistar rats with collagen type II. Plumbagin (2 and 6 mg/kg) was orally administered to rats with CIA from day 12 to day 32 post immunization. The effects of plumbagin on arthritis progression were assessed by paw swelling, clinical scoring, and histologic analysis. The percentage of Treg and Th17 were defined by flow cytometry or immunofluorescence (IF) staining. Bone erosion and resorption were assessed by micro-CT and histomorphometric analysis. Osteoclast differentiation was further determined by in vitro osteoclastogenesis assay. The molecular docking assay was used to determine the potential binding site of plumbagin.Results: Treatment with plumbagin significantly inhibited arthritis development, as well as suppressed the local and systemic inflammation. Plumbagin reciprocally regulated pro-inflammatory Th17 cell and immunosuppressive Treg cell populations. In addition, plumbagin protected inflammation-induced bone loss by inhibiting osteoclast formation and activity. Plumbagin markedly suppressed RANKL-stimulated osteoclast-specific gene expression by repressing NF-κB signaling activation and MAP kinase phosphorylation. Further study via molecular docking assay demonstrated that plumbagin bound to MET169 of JNK kinase and LYS138 and SER183 of p38 kinase.Conclusion: Plumbagin not only attenuates the immune-induced arthritis by inhibiting inflammation, but also protects bone erosion by directly inhibiting osteoclast formation and activity. These data suggest plumbagin is a promising new candidate drug for treating inflammatory joint diseases.
« Déserts médicaux » en France : état des lieux et perspectives de recherches
Authors: Chevillard Guillaume , Lucas-Gabrielli Véronique , Mousques Julien 
Published: January 2019

L’expression de « déserts médicaux » est abondamment utilisée pour décrire des territoires où les habitants rencontrent des difficultés d’accès aux soins. Cette expression n’apparaît pas assez précise, ni pour décrire la pluralité des difficultés rencontrées, ni pour réfléchir aux mesures permettant de les résoudre. L’objectif de cet article est d’abord d’analyser l’évolution de la mesure d’un faible niveau d’accessibilité aux médecins généralistes à travers le temps. Nous analysons ensuite les réponses des pouvoirs publics aux « déserts médicaux » par deux éléments : la définition de zones prioritaires et le déploiement de mesures pour y attirer et maintenir des médecins généralistes. À partir des constats établis et du cadre conceptuel usité, nous proposons des perspectives de recherches pour améliorer la description de l’accessibilité aux médecins généralistes ainsi que l’évaluation de la politique menée contre les « déserts médicaux ».
Réflexions sur la notion de donnée publique
Authors: Boul Maxime 
Published: January 2019

Résumé Dans une société et une économie numérisées, les données sont au centre de problématiques majeures. Données publiques et données personnelles se répondent avec des encadrements juridiques croisés : la loi pour une République numérique du 7 octobre 2016 et le règlement général pour la protection des données « RGPD ». Pourtant la notion de donnée publique est difficilement saisie par le droit. Elle ne fait l’objet d’aucune définition. Information du service public, elle est concurrencée par de nouvelles notions. Bien au service du public, elle ne répond pas totalement aux définitions des biens publics et des facilités essentielles. Ainsi, ni le discours du droit ni le discours sur le droit n’ont réussi à appréhender cette notion.
Vers l’État-plateforme ?
Authors: Chevallier Jacques 
Published: January 2019

Résumé L’État-plateforme est le produit d’une politique volontariste visant à adapter l’État aux défis de l’ère numérique : passant par la diffusion des données publiques et la production de services numériques, cette politique est appelée à connaître de nouveaux développements, à la faveur de la mise en œuvre du « Plan d’action pour un gouvernement ouvert ». La conception d’un État souple, agile, flexible qui le sous-tend ne saurait manquer d’avoir un impact plus large, en travaillant en profondeur l’architecture étatique.
Un jeu de chaises musicales biaisé – Les effets de la RéATE sur les carrières des cadres du Ministère de l’écologie
Authors: Alber Alex 
Published: January 2019

Résumé Cet article, qui synthétise les résultats d’une recherche sur les blocages de carrière chez les cadres expérimentés du Ministère de l’écologie, vise à présenter les enjeux d’une transition inaboutie entre un modèle historique de « gestion administrée » et un modèle de « marché » censément plus attentif aux compétences, notamment managériales. Nous montrons, d’une part, comment certains agents se sont trouvés désavantagés par les nouvelles règles du jeu et, d’autre part, comment une minorité a su se saisir de ces nouvelles opportunités pour progresser en marge des circuits conventionnels. Finalement, nous montrons comment la situation étudiée questionne une possible dualisation de l’emploi public.