bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic Nicotine Exposure Alters the Neurophysiology of Habenulo-Interpeduncular Circuitry
Authors: Arvin Matthew C. , Jin Xiao-Tao , Yan Yijin , Wang Yong , Ramsey Matthew D. , Kim Veronica J. , Beckley Nicole A. , Henry Brittany A. , Drenan Ryan M. 
Published: March 2019

Antagonism of nicotinic acetylcholine receptors (nAChRs) in the medial habenula (MHb) or interpeduncular nucleus (IPN) triggers withdrawal-like behaviors in mice chronically exposed to nicotine, implying that nicotine dependence involves the sensitization of nicotinic signaling. Identification of receptor and/or neurophysiological mechanisms underlying this sensitization is important, as it could promote novel therapeutic strategies to reduce tobacco use. Using an approach involving photoactivatable nicotine, we previously demonstrated that chronic nicotine (cNIC) potently enhances nAChR function in dendrites of MHb neurons. However, whether cNIC modulates downstream components of the habenulo-interpeduncular (Hb-IP) circuit is unknown. In this study, cNIC-mediated changes to Hb-IP nAChR function were examined in mouse (male and female) brain slices using molecular, electrophysiological, and optical techniques. cNIC enhanced action potential firing and modified spike waveform characteristics in MHb neurons. Nicotine uncaging revealed nAChR functional enhancement by cNIC on proximal axonal membranes. Similarly, nAChR-driven glutamate release from MHb axons was enhanced by cNIC. In IPN, the target structure of MHb axons, neuronal morphology, and nAChR expression is complex, with stronger nAChR function in the rostral subnucleus [rostral IPN (IPR)]. As in MHb, cNIC induced strong upregulation of nAChR function in IPN neurons. This, coupled with cNIC-enhanced nicotine-stimulated glutamate release, was associated with stronger depolarization responses to brief (1 ms) nicotine uncaging adjacent to IPR neurons. Together, these results indicate that chronic exposure to nicotine dramatically alters nicotinic cholinergic signaling and cell excitability in Hb-IP circuits, a key pathway involved in nicotine dependence.SIGNIFICANCE STATEMENTThis study uncovers several neuropharmacological alterations following chronic exposure to nicotine in a key brain circuit involved in nicotine dependence. These results suggest that smokers or regular users of electronic nicotine delivery systems (i.e., “e-cigarettes”) likely undergo sensitization of cholinergic circuitry in the Hb-IP system. Reducing the activity of Hb-IP nAChRs, either volitionally during smoking cessation or inadvertently via receptor desensitization during nicotine intake, may be a key trigger of withdrawal in nicotine dependence. Escalation of nicotine intake in smokers, or tolerance, may involve stimulation of these sensitized cholinergic pathways. Smoking cessation therapeutics are only marginally effective, and by identifying cellular/receptor mechanisms of nicotine dependence, our results take a step toward improved therapeutic approaches for this disorder.
The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells
Authors: Ignarski Michael , Rill Constantin , Kaiser Rainer W.J. , Kaldirim Madlen , Neuhaus René , Esmaillie Reza , Li Xinping , Klein Corinna , Bohl Katrin , Petersen Maike , Frese Christian K. , Höhne Martin , Atanassov Ilian , Rinschen Markus M. , Höpker Katja , Schermer Bernhard , Benzing Thomas , Dieterich Christoph , Fabretti Francesca , Müller Roman-Ulrich 
Published: March 2019

Significance Statement
RNA-binding proteins (RBPs) are crucial regulators of cellular biology, and recent evidence suggests that regulation of RBPs that modulate both RNA stability and translation may have a profound effect on the proteome. However, little is known about regulation of RBPs upon clinically relevant changes of the cellular microenvironment. The authors used high-throughput approaches to study the cellular RNA‐binding proteome in differentiated tubular epithelial cells exposed to hypoxia. They identified a number of novel RBPs (suggesting that these proteins may be specific RBPs in differentiated tubular epithelial cells), and found quantitative differences in RBP-binding to mRNA associated with hypoxia versus normoxia. These findings demonstrate the regulation of RBPs through environmental stimuli and provide insight into the biology of hypoxia-response signaling in the kidney.

Background
RNA-binding proteins (RBPs) are fundamental regulators of cellular biology that affect all steps in the generation and processing of RNA molecules. Recent evidence suggests that regulation of RBPs that modulate both RNA stability and translation may have a profound effect on the proteome. However, regulation of RBPs in clinically relevant experimental conditions has not been studied systematically.

Methods
We used RNA interactome capture, a method for the global identification of RBPs to characterize the global RNA‐binding proteome (RBPome) associated with polyA-tailed RNA species in murine ciliated epithelial cells of the inner medullary collecting duct. To study regulation of RBPs in a clinically relevant condition, we analyzed hypoxia-associated changes of the RBPome.

Results
We identified >1000 RBPs that had been previously found using other systems. In addition, we found a number of novel RBPs not identified by previous screens using mouse or human cells, suggesting that these proteins may be specific RBPs in differentiated kidney epithelial cells. We also found quantitative differences in RBP-binding to mRNA that were associated with hypoxia versus normoxia.

Conclusions
These findings demonstrate the regulation of RBPs through environmental stimuli and provide insight into the biology of hypoxia-response signaling in epithelial cells in the kidney. A repository of the RBPome and proteome in kidney tubular epithelial cells, derived from our findings, is freely accessible online, and may contribute to a better understanding of the role of RNA-protein interactions in kidney tubular epithelial cells, including the response of these cells to hypoxia.
AZERBAYCAN – SOVYET YAZARLARININ YARATICILIĞINDA TÜRKİYE: 1960-1980 DÖNEMİ KAYNAKLARINA BİR BAKIŞ
Authors: AHMADOV Namiq 
Published: March 2019

Sovyet lideri
Stalin’in ölümünden sonra demir perdelerin kaldırılması Türkiye ile
ilişkilerin yeniden oluşturulmasında yeni bir dönem başlattı. Sovyetler
Birliği ile Türkiye arasında yapılan bilimsel ve kültürel anlaşmalardan, yani
1964 senesinden sonra Azerbaycan’dan birçok yazar, sanat ve bilim insanının
Türkiye’ye seyahati için olanaklar sağlandı. Azerbaycan Sovyet basınında, Türkiye ile
ilgili konularda yazılarıyla toplumun merakını gidermeye çalışan ilk isimler
arasında, Mehdi Hüseyin, Gasım Gasımzadə,
Elçin ve Memmed Aslan’ın adlarını anmamız gerekir. Azerbaycan’ın ünlü yazarı, dramaturg,
eleştirmen, aydın Mehdi Hüseyin’in Türkiye’ye ilk kez gidişi ve 1964 senesinde “Bir Ay ve Bir Gün” adlı kitabının okurlara sunulması dönemin
en önemli olaylarından birisiydi. Daha sonraki dönemlerde Gasım Gasımzade, Elçin ve Memmed Aslan’ın Türkiye
ile ilgili kitapları da yayınlar
arasında yerini almıştı.Azerbaycan-Türkiye
ilişkileri bakımından
değerlendirildiğinde, eleştirmenler
tarafından bugün bile edebiyatın iyi örnekleri olarak kabul edilen
bu değerli sanat eserleri bu konuda yazılmış ilk örnekler olarak kabul edilmektedir.

İzvestiya
gazetesinin Türkiye’deki muhabirleri olarak
çalışan Azad Şerifov ve Zaur Gadimbeyov’un kardeş Türkiye’de yaşadıklarıyla ilgili
izlenimlerinin yer aldığı eserleri de Sovyet döneminde ses getirmiştir.
Образ Востока в пьесе К. Марло «Тамерлан Великий»
Authors: Крылова Елизавета Евгеньевна 
Published: March 2019

<p>В статье рассмотрено, каким предстает Восток в пьесе «Тамерлан Великий» К. Марло. Автор анализирует, как этот образ соотносится с историческим Тамерланом и современным ему Востоком, каковы взаимоотношения между европейским миром и восточным в пьесе, а также насколько правомерно включать пьесу Марло (и, в принципе, творения его современников) в популярный ныне постколониальный дискурс.</p><p>В виде доклада исследование было представлено на I Всероссийской научной конференции «Кристофер Марло и его творчество в русской и мировой культуре: междисциплинарный взгляд» (Москва, 22–23 июня 2018 г.). Конференция была проведена в рамках проекта Российского фонда фундаментальных исследований (№ 18-012-00679).</p>
La crítica como ética del cuidado de sí
Authors: Scasserra José Ignacio 
Published: March 2019

El trabajo se propone evaluar el comentario de Michel Foucault al texto de Kant “¿Qué es la ilustración?” con el fin de dar cuenta de las continuidades que dicho comentario presenta para con la genealogía de las prácticas de sí greco – latinas que Foucault se encontraba estudiando entre los años 1980 y 1984, apartándose de este modo de una lectura que considere los trabajos foucaultianos sobre la Ilustración como un momento aislado de su producción en los años 80. Para ello, en primer lugar, se desarrollará el texto kantiano sobre la ilustración, luego abordaremos el modo en que Foucault enmarcó sus trabajos en dichos años en el prólogo de El uso de los placeres, para finalmente dirigirnos a los dos textos de Foucault sobre la ilustración. Nuestro desarrollo será realizado prestando atención a un triple gesto que creemos encontrar tanto en el texto kantinao como en el foucaultiano: la descripción, la adscripción, y la prescripción de ambos autores hacia el proyecto ilustrado. Dicha “similitud estructural” nos permitirá ordenar los desarrollos de ambos.
El paisaje atlántico vasco ante la marginalización ganadera: claves para su conservación
Authors: Alberdi Collantes Juan Cruz 
Published: March 2019

La investigación parte de la premisa de que una abandono de las funciones ganaderas originaria una reacción similar en los usos del suelo, siendo el paisaje de campiña atlántica el principal afectado. La metodología se centra en el estudio de casos y en la entrevista, como medios para completar y cualificar la información oficial. Los resultados muestran que el abandono ganadero es, si cabe mayor que el esperado pero, en apariencia, los usos del suelo apenas se alteran. Se analizan las causas, a menudo no productivas, que explican esta situación y se concluye que es una situación transitoria. Las acciones propuestas que pudieran frenar este proceso tan sólo amortiguarán el escenario previsto, la pérdida del paisaje atlántico de buena parte del País Vasco.
Extend Surface Casing Deeper to Eliminate Borehole Instability in Oil Field Turnkey Project
Authors: Ullah Syed Zahoor , Al-Fakih Abdulqawi , Almomen Mohammed Sami , Famiev Robert , Alatiyyah Ahmed Subhi , Al Sharif Taimour 
Published: March 2019

Abstract
In one of the largest oil fields in Middle East, the typical well design is to set the conductor just 40 ft below the ground, the surface casing 100 ft inside next competent formation due to shallow total loss zone below the conductor and the intermediate casing in the first competent formation before entering the reservoirs interval. The intermediate section includes a combination of formations that have total losses zones and extremely unstable shales, especially when drilled with total losses.
In most cases, encountering lost circulation results in formation collapse. The severity of the formation collapse risk in this section ranges from simple tights spots cleared with reaming up and down to stuck pipes, sidetracks and in several cases plug and abandonment of wells. To reduce the likelihood and severity of this risk, there was a need to review the casing seats to isolate unstable formations before entering the intermediate loss zones.
A detailed study was carried out where diverse options were analyzed, including adding a casing string and changing casing seats of existing casing strings. The study concluded that keeping the same number of casing strings and deepening only the surface casing seat as close as possible to the intermediate loss zone, covering the entire unstable formation but not entering the intermediate loss zone, would be the most efficient solution. Experts supported this change based on the principle that dealing with an unstable formation when it is below the loss zone is easier than when the same formation is above the loss zone.
The new casing seat choice has been successfully implemented at over 100 wells, with 100% success ending the borehole instability problems. Since then there has been no sidetrack or location plugged and abandoned for borehole instability in intermediate section.
This paper encompasses a comprehensive analysis of the mechanism of unstable formations reaction to the loss circulation, resultant stuck pipe mechanisms, unsuccessful attempts to cure losses in this zone, improving fly mixed mud inhibition, impacts of modifications in well design on zonal isolation and finally reaching the safest, time and cost-effective solution.
An Intelligent Data-Driven Framework to Develop New Correlation to Predict Gas Deviation Factor for High-Temperature and High-Pressure Gas Reservoirs Using Artificial Neural Network
Authors: Tariq Zeeshan , Mahmoud Mohamed , Asad Abdul 
Published: March 2019

Abstract
The gas deviation factor (Z-factor) is an effective thermodynamic property required to address the deviation of the real gas behavior from that of an ideal gas. Empirical models and correlations to compute Z-factor based on the equation of states (EOS) are often implicit, because they needed huge number of iterations and thus computationally very expensive. Many explicit empirical correlations are also reported in the literature to improve the simplicity; yet, no individual explicit correlation has been formulated for the complete full range of pseudoreduced temperatures and pseudo-reduced pressures, which demonstrates a significant research gap. The inaccuracy in determining gas deviation factor will lead to huge error in computing subsequent natural gas properties such as gas formation volume factor (Bg), gas compressibility (cg), and original gas in place (OGIP). Previously reported empirical correlations provide better estimation of gas deviation factor at lower pressures but at higher reservoir pressures their accuracies becomes questionable.
In this study, a simple and improved Z-factor empirical model is presented in a linear fashion using a robust artificial intelligence (AI) tool, the Artificial Neural Network (ANN). The new model is trained on more than 3000 data points from laboratory experiments obtained from several published sources. The proposed model is only a function of pseudo reduced temperature and pseudo reduced pressure of the gases which makes it simpler than the existing implicit and complicated correlations. The accuracy and generalization capabilities of the proposed ANN based model is also tested against previously published correlations at low and high gas reservoir pressures on an unseen published dataset.
The comparative results on a published dataset show that the new model outperformed other methods of predicting Z-factor by giving less average absolute percentage error (AAPE), less root mean square error (RMSE) and high coefficient of determination (R2). The error obtained was less than 3% compared to the measured data.
Geomechanical Integration Maximizes the Value For Waterflood Developments in the Sultanate of Oman
Authors: Al Zadjali Ruqaiya , Mahajan Sandeep 
Published: March 2019

Abstract
Water flooding has been widely used as secondary oil recovery method in the clastic reservoirs in PDO. Field development plan of this field requires water injection under matrix injection conditions. The field consists of stacked Gharif sand stone reservoirs with variable degree of depletion. Increased injection volumes at economical rate, could induce hydraulic fracturing where it is very important to manage fracture growth and reducing risk for out of zone injection. The success of water flood development depends on an optimal injection pressure, which requires knowledge of formation fracture pressures and geomechanical rock properties.
Efficient geomechanical analysis and workflow integrating data from well tests, field performance, water injection history and monitoring data was implemented for this study to provide guidance on optimum water injection pressure. Field stress tests, such as Leak off Tests (LOT) and micro fracs were analyzed to derive the fracture pressures. Gharif formation in these stacked reservoir formations have been significantly depleted hence a reduction in fracture pressure was required to be assessed. Depletion stress path coefficient, which is the ratio of change of fracture pressure and reservoir depletion, was derived based on historic field data. Data from well tests, field water injection performance was used for Modified Hall plot analysis and other diagnostic plots to provide better insight on active water injection operating conditions (fracture, matrix and plugging). Finally, for injector operating above the fracture pressure, Produced Water Re-Injection (PWRI) model was used to simulate expected fracture dimensions, and quantify the out of zone injection risk.
Results of this study indicate that the decrease in fracture pressure in Gharif formations is about 60% of the change in pore pressure (depletion). Qualitative and quantitative analyses were able to characterize the operating injection conditions (matrix vs. fractured) for active injectors. Interpreted fracture pressure from Gharif water injector diagnostic plots demonstrates good alignment with the measured fracture pressure from field tests. The results reveal that most of the water injector wells, particularly in the depleted formations are operating above fracturing pressure. Predicted fracture dimensions form the PWRI model calibrates well with the field monitoring data.
Outcome of this study provided fracture pressure estimate for Gharif formation with depletion and provide guidance on optimum water injection pressure to improve waterflood management. Stress path chart provide continuous improvement and quick decision for water flood operation. Results quantified the induced fracturing to mitigate the risk of out of zone injection and/or loss of sweep efficiency.
Additionally, the results provide continuous critical input for fracture gradient for drilling and cement design for wells through depleted stacked reservoirs in other field within Gharif formation.
The End of Petroleum Engineering as We Know It
Authors: Mathieson Derek , Meehan D. Nathan , Potts Jeff 
Published: March 2019

Abstract
"Would you recommend that your son or daughter go into petroleum engineering?"
This is a question SPE presidents and senior executives have been asked for decades and, for most of the last 40 years, the answer has been positive. However, how realistic is a positive response today?
In today's society, negative attitudes toward the extractive industries, and fossil fuels in particular, have made the oil & gas industry less attractive to college students. In addition, this negative opinion has been greatly exacerbated by issues surrounding climate change, not to mention the seemingly constant cyclical demand and massive layoffs during downturns. Factor in the inherent pressure for efficiency, new data-driven approaches and AI-based systems and the future of petroleum engineering looks to be quite different from what has been experienced in the past. In addition, decreasing oil demand in American and Europe may well portend radical changes in how the industry functions.
New Workflow of Facies Modeling Based on Deposition Study, Seismic Data and Artificial Modification: A Case Study for the Mishrif Formation of the H Oilfield, Iraq
Authors: Han Rubing , Li Shunming , Song Benbiao , Tian Changbing 
Published: March 2019

Abstract
The giant H oil field was discovered in 1976 and put into development in 2008. The Mishrif reservoir has half of the geological reserves, and the current development challenges are greater. First, the sedimentary evolution is very complicated (inner ramp, lagoon, shallow sea, et al), the existing facies model is generally derived from rock type interpolation with kriging algorithm, and does not reflect sedimentary understanding, and is quite different from the actual situation displayed by seismic data. Furthermore, the variogram of rock types is also difficult to be accurate, resulting in poor fitting of reservoir simulation. Second, the seismic data quality is generally low, and its correlation with rock types is worse. If it is directly used to constrain rock type interpolation, the accuracy is generally unsatisfactory.
In order to solve these problems, this study first comprehensively studied the core, thin slices, scanning electron microscopy, X-ray diffraction, electron probe and other data for sequence stratigraphy and sedimentary research. Secondly, based on the single well facies interpretation, combined with the inversion data, the dimension, spatial relationship and variogram of each depositional element were studied. Thirdly, the facies model was built using the Sequential Indicator Simulation (SIS) algorithm, and was manually modified zone by zone according to the sequence stratigraphy and sedimentary understanding. Finally, the relationship between depositional elements and rock types was studied, and the probability bodies of different depositional elements with different rock types were obtained. Based on this, the SIS algorithm was used to simulate rock types. Then this could be further used as a constraint to build petrophysical models.
The results showed that the correlation between the depositional elements and the rock type was obviously better than the inversion wave impedance. The artificially modified facies model could better reflect sedimentary appearance, and various static and dynamic data. The rock type model obtained under the constraint of the facies model also bypassed the problem that the seismic data quality was not good enough for direct rock type interpolation.
It was verified that with the new modeling workflow, the preliminary numerical simulation fitting rate reach over 80%. The facies model was then verified with water flooding test in H oil field and had good results. This workflow could provide a good reference for similar oilfields in the Middle East.