bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh senam kegel terhadap proses involusio uterus pada ibu post partum
Authors: Sarwinanti Sarwinanti 
Published: February 2019

Metode penelitian ini merupakan penelitian kuantitatif eksperimental dengan jenis rancangan Pra Eksperimen Post Test Only Design. SampelÂ dalam penelitian ini berjumlah 30 responden.Â Metode analisa data menggunakan Mann Whitney-Test. Hasil penelitian didapatkan dari 9 responden yang melakukan senam kegel ada 8 responden yang proses involusionya baik dan 1 responden yang proses involusionya buruk. Pada 21 responden yang tidak dilakukan senam kegel terdapat 6 responden dengan proses involusionya baik dan 15 responden dengan proses involusionya buruk. Kesimpulan dari penelitian ini adalah ada pengaruh senam kegel terhadap proses involusio uterus ibu post partum.
Teh hijau meningkatkan jumlah sel epitel tuba fallopi dan endometrium tikus dipapar sipermetrin
Authors: Sawitri Lia , Handayani Ririn , Norahmawati Eviana , Winarsih Sri , Ratnawati Retty 
Published: February 2019

Sipermetrin adalah pestisida golongan insektisida, yang dapat mempengaruhi organ reproduksi hingga menyebabkan infertil. Tujuan penelitian adalah mengetahui pengaruh teh hijau terhadap jumlah sel epitel tuba fallopi dan endometrium tikus yang dipapar sipermetrin.Â Ekstrak teh hijau merupakan hasil maserasi larutan etanol 96%. Penelitian ini dilakukan secara eksperimental menggunakan 25 ekor tikus betina dewasa. Hasil penelitian menunjukkan kelompok kontrol positif memiliki jumlah sel epitel yang paling sedikit, sedangkan kontrol negatif memiliki jumlah sel epitel yang paling banyak. Kelompok perlakuan menunjukkan bahwa P3 dengan dosis teh hijau paling tinggi menunjukan jumlah sel epitel yang paling banyak namun tidak berbeda signifikan dengan kontrol negatif.
Experimental evidence for 2SG direct object pronoun preferences in Brazilian Portuguese
Authors: Schwenter Scott A. , Hoff Mark , Dickinson Kendra V. , Bland Justin , Lamberti Luana 
Published: February 2019

We examine the competition in Brazilian Portuguese 2SG direct object pronoun expression between clitic te and tonic você (e.g. Eu te vi ~ Eu vi você). We offer data from an online forced-choice survey, analyzed using mixed-effects logistic regression, to show that dialectal subject pronoun preference (tu/você) and contrast both play a significant role in conditioning this choice. Furthermore, we find that contrast, despite its traditional treatment as binary, shows gradient effects on pronoun choice- while te is the preferred DO pronoun overall, você is the variant preferred in contrastive contexts, especially in cases of double contrast.-----------------------------------------------------------------------------EVIDÊNCIAS EXPERIMENTAIS POR PREFERÊNCIAS PRONOMINAIS DE OBJETOS DIRETOS DE 2SG EM PORTUGUÊS BRASILEIROExaminamos a competição no português brasileiro entre o pronome clítico te e o tônico você para a expressão de objetos diretos de segunda pessoa singular (Eu te vi ~ Eu vi você). Apresentamos dados recolhidos de um questionário, e analizados utilizando a regressão logística de efeitos mistos, para mostrar que tanto a preferência do pronome de sujeito (você/tu) quanto o contraste têm um papel importante na escolha do pronome de objeto direto. Também, o contraste, apesar do tratamento tradicional como binário, mostra efeitos gradáveis na escolha de pronome- enquanto o te é preferido em termos globais, você é preferido em contextos contrastivos, especialmente nos casos de duplo contraste.---Original em inglês.
Perfil y endofenotipos neuropsicológicos en TDAH: Una revisión
Authors: Rubio Belén , Castrillo Jennifer , Herreros Oscar , Gastaminza Xavier , Hernández Sergio 
Published: February 2019

Existe un acuerdo científico generalizado acerca de que un porcentaje elevado de las personas que presentan Trastorno por Déficit de Atención con Hiperactividad (TDAH) tienen también importantes dificultades en su rendimiento psicológico. Esta afirmación cuenta con evidencias cognitivo-conductuales y neurofuncionales. Así, están ampliamente constatados los problemas en el funcionamiento ejecutivo en los pacientes con TDAH, encontrándose, en especial, tamaños de efecto robustos para la memoria de trabajo y la inhibición. En este trabajo se presenta una revisión del perfil neuropsicológico más frecuentemente encontrado en TDAH, y se discuten los distintos modelos explicativos y dificultades en el endofenotipado neuropsicológico.
Tumor de Wilms Bilateral Sincrônico: Avaliação Cirúrgica e Sobrevida
Authors: Oliveira Pablo Baptista , Grabois Marilia Fornaciari , Lima Fernanda Ferreira da Silva , Faria Paulo Antônio Silvestre de , Santos Vanessa do Nascimento , Gutierrez Francisca Norma Albuquerque Girão , Ferman Sima Esther , Carvalho Ricardo Vianna de 
Published: February 2019

Introdução: Os tumores renais representam cerca de 7% de todas as neoplasias malignas da infância. O tumor de Wilms bilateral sincrônico corresponde a 5-7% de todos os nefroblastomas. O tratamento consiste em quimioterapia pré-operatória, seguida de cirurgia conservadora, quimioterapia pós-operatória e, quando indicada, radioterapia. Objetivo: Analisar o tipo de cirurgia e a sobrevida global dos pacientes com tumor de Wilms bilateral sincrônico. Método: Este estudo de coorte retrospectivo incluiu 18 pacientes pediátricos do Hospital do Câncer I, do Instituto Nacional de Câncer José Alencar Gomes da Silva, no Rio de Janeiro, de janeiro de 2000 a dezembro de 2017. Curvas de sobrevida foram calculadas pelo método Kaplan-Meier. Resultados: A idade mediana ao diagnóstico foi de 19 meses, sendo dez casos do sexo feminino. Em 62,5% dos rins operados, foi possível realizar cirurgia conservadora e, em 41,2% (7/17) dos pacientes, em ambos os rins. A sobrevida global em cinco anos, segundo o tipo cirurgia, foi de 87,5% para cirurgia conservadora e de 62,8% para nefrectomia total (p=0,0001). A sobrevida global em cinco anos para a coorte inteira foi de 70,8%. Conclusão: A cirurgia preservadora de tecido renal em crianças com o tumor de Wilms bilateral sincrônico é viável e pode ser realizada com segurança em centros de referência.
Perfil Nutricional de Crianças Portadoras de Tumores Cerebrais com Síndrome Diencefálica ou Síndrome de Russell recebendo Dieta Enteral
Authors: Garófolo Adriana , Silva Nasjla Saba , Cavalheiro Sérgio 
Published: February 2019

Introdução: A síndrome diencefálica é uma doença pediátrica rara, decorrente de tumores hipotalâmicos, caracterizada por failure to thrive. Objetivo: Descrever o estado nutricional e a terapia nutricional por meio de sonda nasoenteral de pacientes com tumores cerebrais com a síndrome diencefálica. Método: Sete pacientes foram acompanhados de julho/1999 a abril/2002 e analisados retrospectivamente, usando os escores-z de peso para idade (P/I), peso para estatura (P/E) e estatura para idade (E/I) no diagnóstico da desnutrição. Todos foram avaliados por meio de composição corporal: prega cutânea triciptal (PCT) e circunferências do braço e muscular do braço (CB e CMB) e receberam alimentação por sonda nasoenteral ou gastrostomia após o diagnóstico da neoplasia. Resultados: A idade variou de 2 meses a 13 anos, cinco do sexo masculino. A duração média da nutrição enteral foi de 7 meses (1,1-18,5) após o diagnóstico, sem diferença estatística significante na evolução dos escores-z, apesar do aumento nas médias de P/I (-4,42 para -3,50) e P/E (-3,06 para -1,99), e dos indicadores de composição corporal (PCT: 2,85 para 4,88; CB: 9,81 para 11,84 e CMB: 8,91 para 10,31). Houve redução na média da E/I, caracterizando o atraso no crescimento dessas crianças. Conclusão: A nutrição enteral demonstrou garantir a oferta nutricional e recuperar em parte os indicadores nutricionais de desnutrição aguda; principalmente a gordura corporal, mais do que massa magra. Entretanto, manteve-se o déficit de crescimento, agravado na maioria dos casos. A terapia nutricional deve ser implantada durante o tratamento oncológico, assegurando sua continuidade.
Impactos do Câncer na Vida Escolar de Crianças e Adolescentes: a Importância da Classe Hospitalar
Authors: Silva Vanessa de Magalhães Gonçalves , Hora Senir Santos da 
Published: February 2019

A escolarização de crianças e adolescente em situações de adoecimento por câncer se apresenta de forma desafiadora, uma vez que o tratamento oncológico impacta nas atividades habituais de escola e lazer desses que vivenciam o contato estreito com situações de dor, mutilações e efeitos colaterais que desencadeiam graves reações físicas e emocionais. Para auxiliar na inclusão escolar da criança e do adolescente que enfrentam tais condições – prevenindo a reprovação e consequente evasão – a classe hospitalar tem sido importante, na medida em que busca oferecer assistência pedagógica aos que se encontram impedidos de frequentar o ambiente escolar formal por motivo de saúde. Nesse sentido, busca-se compreender os impactos do adoecimento por câncer à vida escolar de crianças e adolescentes, considerando as possíveis sequelas do tratamento oncológico e os desafios do atendimento pedagógico hospitalar para inclusão escolar desses sujeitos.
Cirurgia Citorredutora e Quimioterapia Intraperitoneal Hipertérmica para Tratamento de Tumor Desmoplásico de Pequenas Células Redondas em Paciente Pediátrico: Relato de Caso
Authors: Coelho Simone de Oliveira , Grabois Marilia Fornaciari , Rebêlo Fabiola Almeida Barros , Carvalho Ricardo Vianna de , Lima Fernanda Ferreira da Silva , Ferman Sima Esther , Souza Filho Odilon 
Published: February 2019

Introdução: O tumor desmoplásico de pequenas células redondas (TDPCR) é uma neoplasia rara com comportamento clínico agressivo. Trata-se do caso de um paciente com 7 anos de idade, sexo masculino, com TDPCR, matriculado no Serviço de Pediatria do Instituto Nacional de Câncer José Alencar Gomes da Silva. Relato do caso: Paciente iniciou o quadro com queixa de dor e aumento do abdome, ascite volumosa, febre e emagrecimento. Nos exames de imagem, apresentava lesão hipodensa no segmento IV A do fígado, ascite volumosa, massa justa parietal no hemitórax direito. O laudo histopatológico foi compatível com TDPCR estádio IV. O paciente foi submetido à quimioterapia sistêmica com resposta completa nas lesões torácicas e redução importante da massa abdominal, restando lesões em cavidade pélvica. O paciente foi submetido à cirurgia com citorredução e hipertermoquimioterapia com cisplatina, e recebeu radioterapia abdominal adjuvante e quimioterapia. O paciente manteve-se estável, apresentando nova progressão e óbito 14 meses após a recidiva. Conclusão: A citorredução cirúrgica associada à hipertermoquimioterapia intraperitoneal permitiu a possibilidade de controle temporário da doença com boa qualidade de vida para o paciente.
Mielinólise Extrapontina em Adolescente com Diabetes Insípidus Secundário a Disgerminoma do Sistema Nervoso Central: Relato de Caso
Authors: Araújo Bruno Espírito Santo de , Castiglione Daniela Capuzzo Dias , Rascão Fernanda Lobo , Victal Sandra Helena dos Santos , Ferman Sima Esther , Lima Fernanda Ferreira da Silva , Capela Fernanda Costa 
Published: February 2019

Introdução: A síndrome de desmielinização osmótica é uma condição neurológica rara causada pelo dano à bainha de mielina dos neurônios, com difícil manejo do distúrbio do sódio em paciente com diabetes insípidus. Relato do caso: Adolescente do sexo feminino, 14 anos, com diabetes insípidus secundária a disgerminoma do sistema nervoso central, com hiponatremia grave (sódio 103 mEq/L). Cinco dias após a correção rápida do sódio, apresentou coma (Escala de Glasgow:11), disfagia, mutismo e tetraparesia. Os achados na ressonância nuclear magnética craniana foram compatíveis com diagnóstico de mielinólise extrapontina. Vinte e cinco dias após a internação no Centro de Tratamento Intensivo, a paciente encontrava-se lúcida, orientada, deambulando sem dificuldade, alimentando-se por via oral, sem engasgos, ainda com discreta diminuição de força nos membros superiores e comunicação verbal pouco lentificada. A ressonância nuclear magnética após três meses mostrou atrofia dos núcleos da base, comprovando lesão celular grave. Conclusão: A desmielinização osmótica pode apresentar-se com formas clínicas leves ou assintomáticas, até sequelas motoras graves e morte. Não existe tratamento específico, o que ressalta a importância do diagnóstico precoce e do manejo adequado do distúrbio do sódio, assim como controle rigoroso dos seus níveis séricos.
The Involvement of Pigment-Protein Fraction from Microalga Nannochloropsis oculata in Expression of Heat Shock Protein 70 with Nervous Necrosis Viral Infection on Grouper
Authors: Yanuhar Uun , Caesar Nico Rahman 
Published: February 2019

The aim of this study is to investigate the expression of heat shock protein 70 (HSP70) on grouper infected by Nervous Necrosis Viral (NNV) with involvement of pigment-protein fraction (PPF) from Nannocloropsis oculata (N.oculata). Fish treatments were divided into three group, which are control, fish with PPF from N.oculata, and fish with PPF and NNV. After treatment for 23 d, fish were sacrificed, and their brain was harvested for protein analysis using SDS-Page. Fish blood was collected to examine the expression of HSP70 by hemagglutination and western blot analysis. The results showed that the expression of HSP70 was observed after treatment with PPF in NNV infected brain tissue and blood cell proved by SDS-Page and Western blot analysis. Thus, PPF is responsible for the expression of HSP70 in infected tissues, indicating that PPF appears to have a function as an inhibitor of proliferation of NNV.
Function of a Sewage Treatment Plant in Rodgau, Germany
Authors: Bialdiga Robin 
Published: February 2019

Rodgau has nearly 50.000 citizens and have their own sewage treatment plant. The wastewater of the whole town has to be treated to the point where it can be released in the back which gives the town its name, the Rodgau. There are two main sources of wastewater, municipal and industrial waste water. (www.rodgau.de 8.9.17)
The objective of Sewage Treatment in Rodgau especially is that the waste water after beingprocess can go directly to Rodau river. The drinking water of Rodgau is not coming from thesewage treatment plant. (Bundesministerium der Justiz und für Verbraucherschutz)
The sewage Treatment Plant in Rodgau has the capacity up to 75.000 citizen value (EW). In this sewage treatment there are physical, chemical and biological processes. In the chemical processes there are neutralization, oxidation and reduction processes. The physical treatment including sedimentation, extraction, and adsorption process. Then main steps of the sewage treatment are screening and filtration of the bigger pollutants, transforming of elements and separating the sludge.( ATV-Handbuch (1999))
Different options can be seen which were used in the Rodgau plant. The Rodgau sewagetreatment plant is at state of the art, very efficient and can be a great example for sewagetreatment plants of other cities.
Real-time Atrial Fibrillation Detection Using Artificial Neural Network on a Wearable Electrocardiogram
Authors: Iskandar Aulia A. , Schilling Klaus 
Published: February 2019

Providing equal healthcare quality on heart diseases are an issue in developing countries, especially in Indonesia, due to is wide-spread areas. It is founded that the heart diseases occur not only in big cities but also in rural areas, that is caused by unhealthy lifestyle and foods. Heart disease itself is a disease with gradually symptoms changes that can be seen based on the hearts' electrical activity or electrocardiogram signals. Now, wearable medical devices are capable to be worn daily, so that, it can monitor our heart condition and alert if there is an abnormality. An embedded device worn on the chest can be used to perform a real-time data acquisition and processing of the electrocardiogram, that consists of a 1-lead ECG, an ARM processor, a Bluetooth module, an SD card, and rechargeable batteries. Also, by performing a digital filter and Tompkins algorithm, we obtain the P-wave presences and the heart rate variability values (heartbeat, average heartbeat, standard deviation, and root mean square) then by using an artificial neural network with 4 input, 6 hidden, and 1 output layers that has multi-layer perceptrons and backpropagation. We are able to perform a pre-diagnosis of atrial fibrillation, that is one of the common arrhythmias, from 41 recorded training samples (Physionet MIT/BIH AFDB and NSRDB) and 6 healthy subjects as test samples. The neural network has 0.1% error rate and needed 31548 epochs to train itself for classification the heart disease. Based on the results, this prototype can be used as a medical-grade wearable device thatcan help cardiologist in giving an early warning on the user's heart condition, so that it can prevent sudden death due to heart diseases in rural areas.
Comparison of Sensitivities of American College of Rheumatology and Systemic Lupus International Collaborating Clinics Classification Criteria in Childhood-onset Systemic Lupus Erythematosus
Authors: Tao Jessie J. , Hiraki Linda T. , Levy Deborah M. , Silverman Earl D. 
Published: February 2019

Objective.Currently there are 2 different classification criteria for systemic lupus erythematosus (SLE): American College of Rheumatology (ACR) and Systemic Lupus International Collaborating Clinics (SLICC). The aim of this study was to compare the sensitivities of ACR and SLICC criteria in childhood-onset SLE (cSLE) using a large, multiethnic cohort.Methods.We conducted a retrospective study of 722 patients diagnosed with cSLE at The Hospital for Sick Children (SickKids). Prospectively collected data from SickKids’ Lupus Database were reviewed/validated against medical records prior to ACR and SLICC scoring based on cumulative symptoms up to the last visit. Sensitivities were compared using McNemar’s test. Descriptive statistics were used to identify SLE features unique to each set of criteria and autoantibodies not included in either.Results.ACR and SLICC sensitivities were as follows: 92.4% and 96.3% overall (p = 0.001); 82.5% and 91.3% (p = 0.01) in those scored ≤ 1 year from diagnosis; 92.7% and 97.9% (p = 0.02) in those scored 2–3 years from diagnosis. Forty-eight of 55 (87.3%) patients who did not meet ACR criteria met SLICC criteria through SLICC-specific criterion or renal biopsy. Twenty of 27 (74.1%) patients who did not meet SLICC criteria met ACR criteria as a result of photosensitivity (73.9%) and ACR lymphopenia criteria (26.1%). Six of 7 patients (85.7%) who were clinically diagnosed with cSLE but did not meet either SLICC or ACR criteria had anti-Ro antibodies.Conclusion.SLICC criteria were significantly more sensitive than ACR criteria in cSLE classification, especially early in the disease course. Because of the extreme rarity of primary Sjögren syndrome in children, one may consider adding anti-Ro antibodies to the classification criteria for cSLE because they are present in ∼40% of patents with cSLE.
Sexual Quality of Life in Patients with Axial Spondyloarthritis in the Biologic Treatment Era
Authors: Berg Kari Hansen , Rohde Gudrun Elin , Prøven Anne , Benestad Esben Esther Pirelli , Østensen Monika , Haugeberg Glenn 
Published: February 2019

Objective.To examine the relationship between demographics, disease-related variables, treatment, and sexual quality of life (SQOL) in men and women with axial spondyloarthritis (axSpA).Methods.AxSpA patients were consecutively recruited from 2 rheumatology outpatient clinics in southern Norway. A broad spectrum of demographics, disease, treatment, and QOL data were systematically collected. SQOL was assessed using the SQOL-Female (SQOL-F) questionnaire (score range 18–108). Appropriate statistical tests were applied for group comparison, and the association between independent variables and SQOL-F was examined using multiple linear regression analysis.Results.A total of 360 (240 men, 120 women) axSpA patients with mean age 45.5 years and disease duration 13.9 years were included. Seventy-eight percent were married/cohabiting, 26.7% were current smokers, 71.0% were employed, 86.0% performed > 1-h exercise per week, and 88.0% were HLA-B27–positive. Mean (SD) values for disease measures were C-reactive protein (CRP) 8.5 (12.1) mg/l, Bath Ankylosing Spondylitis Disease Activity Index 3.1 (2.1), Bath Ankylosing Spondylitis Global Score (BAS-G) 3.8 (2.5), Bath Ankylosing Spondylitis Functional Index 2.7 (2.2), and Health Assessment Questionnaire 0.6 (0.5). The proportion of patients using nonsteroidal antiinflammatory drugs was 44.0%, synthetic disease-modifying antirheumatic drugs (DMARD) 5.0%, and biologic DMARD 24.0%. Mean (SD) total sum score for SQOL was 76.6 (11.3). In multivariate analysis, female sex, increased body mass index, measures reflecting disease activity (BAS-G and CRP), and current biologic treatment were independently associated with a lower SQOL.Conclusion.Our data suggest that inflammation in patients with axSpA even in the biologic treatment era reduces SQOL.
The Effect of Axial Spondyloarthritis on Mental Health: Results from the Atlas
Authors: Garrido-Cumbrera Marco , Delgado-Domínguez C.J. , Gálvez-Ruiz D. , Mur C. Blanch , Navarro-Compán V. 
Published: February 2019

Objective.To assess the risk of mental disorders in patients with axial spondyloarthritis (axSpA) and to examine the factors associated with this.Methods.In 2016, a sample of 680 patients with axSpA were interviewed as part of the development process for the Atlas of Axial Spondyloarthritis in Spain. The risk of mental disorders in these patients was assessed using the 12-item General Health Questionnaire scale. Additionally, the variables associated with the risk of mental disorders were investigated, including sociodemographic characteristics (age, sex, relationship, patient association membership, job status, and educational level), disease status (Bath Ankylosing Spondylitis Disease Activity Index, spinal stiffness, and functional limitation), and previous diagnosis of mental disorders (depression and anxiety). Bivariate correlation analyses were performed, followed by multiple hierarchical and stepwise regression analysis.Results.A total of 45.6% patients were at risk of mental disorders. All variables except educational level and thoracic stiffness significantly correlated with risk of mental disorders. Nevertheless, disease activity, functional limitation, and age showed the highest coefficient (r = 0.543, p ≤ 0.001; r = 0.378, p ≤ 0.001; r = −0.174, p ≤ 0.001, respectively). In the stepwise regression analysis, 4 variables (disease activity, functional limitation, patient association membership, and cervical stiffness) explained the majority of the variance for the risk of mental disorders. Disease activity displayed the highest explanatory degree (R2 = 0.875, p < 0.001).Conclusion.In patients with axSpA, the prevalence of risk of mental disorders is high. Combined with a certain sociodemographic profile, high disease activity is a good indicator of the risk for mental disorders.
Adaptive Trial Designs in Rheumatology: Report from the OMERACT Special Interest Group
Authors: Pickles Tim , Alten Rieke , Boers Maarten , Bykerk Vivian , Christensen Jared , Christensen Robin , van Hoogstraten Hubert , Simon Lee S. , Tam Lai-Shan , Choy Ernest H. 
Published: February 2019

Objective.Adaptive trial design was developed initially for oncology to improve trial efficiency. If optimized for rheumatology, it may improve trial efficiency by reducing sample size and time.Methods.A systematic review assessed design of phase II clinical trials in rheumatoid arthritis.Results.Fifty-six trials were reviewed. Most trials had 4 groups (1 control and 3 intervention), with an average group size of 34 patients. American College of Rheumatology 20 measured at 16 weeks was the most commonly used primary endpoint.Conclusion.The next step is to undertake a systematic review of adaptive designs used in early-phase trials in nonrheumatic conditions.