bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ozonotherapy influence on hormonal status of pregnant women of older reproductive age
Authors: Safarova R. B. 
Published: October 2019

Aim. To study the hormonal status in pregnant women of older reproductive age and estimate the influence of administration of medical ozone on the course of pregnancy.
Materials and methods. Ninety pregnant women aged 3544 years were examined over the period from 2013 to 2015. They were randomized by their age, social factors, associated gynecological and extragenital diseases. The main group (group I) joined 30 patients, the group of comparison (group II) 30 patients and the control (group III) 30 patients. All the patients underwent clinical and laboratory investigations according to the existing standards of obstetric examination. In the main group, complex treatment included therapy with medical ozone. In the comparison group, a standard medico-preventive therapy by the protocol №05 (20.02.2014 MH of AR) was implemented. In the control group, estrogen indices were studied in dynamics.
Results. Pregnant women aged 35 years and older have an unfavorable background of extragenital and gynecological pathology that is confirmed by hormonal background.
Conclusions. Planning of pregnancy, timely prevention and correction of clinicolaboratory indices permit to reduce the frequency and severity of pregnancy and delivery complications and improve the perinatal indices among patients of this age group.
Influence of congenital heart disease-caused hypoxia on intrathymic development of t-lymphocytes in children of first year of life
Authors: Loginova N. P. , Chetvertnykh V. A. , Khromtsova G. A. , Shekhmametyev R. M. , Chetvertnykh L. A. 
Published: October 2019

Aim. To study the influence of hypoxia, caused by congenital heart disease, on the intrathymic development of T-lymphocytes and provision of the organism with T-cellular resource in children with cardiac pathology of different degree of severity.
Materials and methods. The paper presents the results of complex immunomorphological study of the thymus in children of the first year of life (n = 129) with congenital heart diseases. Hystochemical and immunological methods were used to assess the influence of congenital heart disease-caused hypoxia on the functional status of thymus regarding provision of a child with T-lymphocytes.
Results. It was established that the degree of severity of congenital heart disease correlated with the degree of suppression of T-lymphocyte pool formation. During the first year of life, proliferative activity of thymocytes (assessed by Ki-67 expression) in the thymus falls, being the reason of decrease in the number of CD3+ thymocytes. In conditions of marked hypoxia (blue type of defect) the process of T-lymphocyte differentiation is inhibited that causes preservation of less mature forms of thymocytes. As a result, hypoxia is the reason of proliferation suppression and thymocyte differentiation, influencing subpopulation composition of the cells. Thus, insufficient quantity of thymic migrants enters the peripheral blood that confirms low functional activity of thymus regarding provision of the organism with T-cellular resource.
Conclusions. No doubt, it can be the cause of immunodeficient state and reduced formation of adaptive immunity in this category of children.
Epidemiological and economic efficiency of mass vaccinal prevention against pneumococcal infection in children compared with selective immunization at the example of community-acquired pneumonia
Authors: Semerikov Vadislav V. , Zubova Elena S. , Sofronova Lyudmila V. 
Published: October 2019

Aim. To study the epidemiological pattern of community-acquired pneumonias in children and the influence of mass vaccinal prevention on morbidity and mortality.
Materials and methods. Vaccination of children against pneumococcal infection on the territory of a large industrial center of Western Urals was analyzed, influence of mass vaccination against pneumococcal infection on pneumonia morbidity and mortality in children was determined.
Results. Mass vaccinal prevention of children of the first year of life against pneumococcal infection (vaccination volume 102 353.6 per 100 thousand children under 6) significantly influenced morbidity level regarding community-acquired pneumonias in the group of vaccinated children under 2 (1619.9 0.78 versus 15233.7 2.5 per 100 thousand in the group of unvaccinated, odds ratio and its confidence interval was 9.40 [95 % CI 8.4610.44]), on community-acquired streptococcal morbidity of children under 6 (r = 0.97; regression coefficient = 36.30, р 0.001; R2 = 91.0 %, significance F = 0.01 and possibility 95.0 %) and 5-fold decreased the mortality level (from 35.2 before vaccination started to 6.8 per 100 thousand) till its full absence in the third year of realization of this strategy. No analogous influence on the main manifestations of epidemiological process of community-acquired pneumonia was noted in case of selective immunization against pneumococcal infection among 25 year olds, belonging to high risk groups (vaccination volume 10 417.08 per 100 thousand children under 6).
Conclusions. The strategy of mass vaccination of children of the first year of life was characterized by the greatest epidemiological and economic benefits. Economic efficiency taking into account vaccination costs in terms of 1000 of vaccinated children was 17.1 times higher and was equal to 8.3656 mln rub per 1000 inhabitants versus 0.4890 mln rub in case of selective immunization of high risk group children.
Clinical case of granulomatosis with polyangiitis (Wegener’s) with isolated pulmonary lesion
Authors: Obukhova Oksana V. , Khlynova Olga V. 
Published: October 2019

Pulmonary vasculites include geterogenic group of diseases, characterized by destruction of pulmonary vessels with inflammation and tissue necrosis. From the clinical point of view, pulmonary vasculites are still difficult to diagnose and treat.
Pulmonary lesion is one of typical features of granulomatosis with polyangiitis (GPA) along with upper respiratory tract and renal pathologies, composing classical triad of this disease.
In case of GPA, pulmonary lesion is diagnosed in 6085 % of patients. As a rule, it is combined with involvement of other organs, but in 9 % of patients, it can be the main manifestation of disease. The paper presents a case of GPA with isolated pulmonary lesion.
Evaluación del nivel de inglés en los programas de enfermería en Colombia: 2011-2016
Authors: Alonso-Cifuentes Julio-César , Estrada-Nates Daniela , Mueces-Bedón Brigitte-Vanessa 
Published: October 2019

Objetivo: evaluar si se cumplió la meta del Gobierno de Colombia para el 2014 de que el 20 % de los graduandos de programas de enfermería de las instituciones colombianas de educación superior se clasifiquen en nivel intermedio o superior en inglés. Metodología: se emplearon los resultados del módulo de inglés de la base de datos de las pruebas Saber Pro del Instituto Colombiano para la Evaluación de la Educación (2011-2016). Los niveles de calificación de este módulo son adaptados del Marco Común Europeo de Referencia. Para inferir respecto al logro de la meta de la política se realizaron pruebas de proporciones paramétricas y no paramétricas. Adicionalmente, se hicieron ajustes sobre el valor p. Resultados: ningún programa cumplió estadísticamente con la meta. Sin embargo, cuando solo se realizó la prueba de comparación de proporciones paramétrica y no paramétrica (sin corrección por hacer múltiples comparaciones), el programa de la Universidad del Valle, sede Cali, sí la cumplió. Conclusión: la meta propuesta por el Programa de Fortalecimiento al Desarrollo de Competencias en Lenguas Extranjeras para el 2014 no se cumplió en el caso de los estudiantes de enfermería evaluados; solo el 2,36 % alcanzó el nivel B+ ese año. Además, se encuentran rezagados respecto a los programas de medicina, economía y administración de empresas.
Pressures and transformations of the Turkish welfare regime
Authors: Soto Carlos 
Published: October 2019

The state, the family and the market are the main pillars of welfare regimes that have different configurations from one country to another. In Turkey, these mechanisms are under increasing pressure today. The family seems unable to extend protection beyond the nuclear household. In addition to that, support to rural employment and urban housing, deployed through clientele networks, decline. Wage insurance, as a way of accessing the social protection system, is also challenged by the characteristics of the labour market. We argue that the structure of employment is increasingly incompatible with the existing welfare system framework, which is mainly centred on formal workers insurance. In this context, will the current pensions and health reforms lead to a better articulation between employment forms and the social protection system? The first part of the article analyzes the evolution of the labour market since the 1990s. Recent adjustments of this market take place in the context of structural changes in the regulation of labour relations and of the economic model. The second part of the article examines social protection reforms. We analyse first parametric adjustments in the case of pensions (retirement age, period of contribution and replacement rates), and secondly, measures adopted to ensure universal access to health care and services. We argue that other forms of insurance and/or assistance might be necessary to increase the scope and depth of coverage. The last section explore three possible transformations of the Turkish welfare regime: increased labour market flexibility, a more important role of private insurance and the scope of social assistance mechanisms.
Credit Take over Agreements with Guarantees of Mortgage Rights at Bank China Construction Bank Indonesia TBK. Pekanbaru Branch
Authors: Indah May Er Rosary , Yulfasni Yulfasni , Mannas Yussy Adelina 
Published: October 2019

Credit take over agreements with guarantees of Mortgage Rights in the banking world can still be said to be attractive because CCB Indonesia Pekanbaru Branch is carrying out a binding agreement on take-over credit and Power of Attorney Imposing Mortgage Rights with the conditions of Land Rights Certificates and Mortgage Certificates still attached Mortgage rights for the Initial Creditors / Banks that are taken over. CCB Indonesia in approving the take over credit facility with the main consideration being that the debtor has a history of credit collectibility in the Debtor Information for the Financial Information Service System / IDEB SLIK OJK with current credit collectability. Debtors choose to take over credit facilities to CCB Indonesia because they obtain lower lending credit interest rates, higher credit facility ceilings, faster approval processes and credit decision making compared to Initial Creditors, free of administrative fees and free of notary fees. The main problem in this study is how to take over credit agreements with guaranteed mortgage rights at Bank China Construction Bank Indonesia Tbk. Pekanbaru Branch. How is the legal protection for the parties with a credit take-over agreement (take over) with guaranteed Mortgage Rights at Bank China Construction Bank Indonesia Tbk. Pekanbaru Branch. The method used in this research is empirical juridical research. Respondents / Informants as well as samples in this study are Credit Operations Head of "CCB Indonesia" Pekanbaru Branch of 1 (one) person and 7 (seven) Notary Partners of "CCB Indonesia" of Pekanbaru Branch. Data collection tool in this study was in the form of an interview. This research is descriptive in nature, providing complete and clear data on loan takeover agreements with guaranteed mortgage rights at Bank China Construction Bank Indonesia Tbk. Pekanbaru Branch. The results of the author's research indicate that the specificity of the credit take-over agreement (guarantee over) with guaranteed Mortgage in Article 3 explicitly specifies that currently the object of Mortgage Guarantee is still in the initial creditor / bank (taken over) and Article 4 expressly specifies that The debtor will transfer the funds to the initial creditor / bank account (taken over) from the proceeds from the disbursement of credit facilities obtained by the Debtor from the CCB Indonesia Pekanbaru Branch. After the signing of the credit agreement has been fulfilled, the Partner Notary issues a Cover Note / Certificate submitted to CCB Indonesia to continue the transfer of funds to the Debtor account at the Initial Creditors / Banks which are overtaken. Legal protection for the Parties in the Take Over Agreement with guaranteed Mortgage is carried out in 2 (two) forms, namely preventive and repressive from CCB Indonesia Creditor and Partner Notary.
Turismo Comunitário e Desenvolvimento Local: uma revisão integrativa sobre a Acolhida na Colônia
Authors: Cunha Lima Felipe Borborema , Silva Yolanda Flores e 
Published: October 2019

Muitos países pobres são levados a acreditar no turismo convencional como um promotor do desenvolvimento. Contudo, se não direcionados às necessidades da população, pode levar à exploração humana e à segregação espacial sem melhorias reais. No final do século XX, o turismo comunitário (TC), ao adotar práticas mais sustentáveis, se contrapõe a esse modelo de turismo. Esta revisão bibliográfica de natureza integrativa objetiva apresentar a discussão brasileira sobre o TC da Associação de Agroturismo Acolhida na Colônia (AAAC). A pesquisa foi via revisão bibliográfica nas bases de dados: Scielo, Icap, Portal de Periódicos Capes, Biblioteca Virtual da USP e Biblioteca Digital Mundial. Os discursos dos autores foram analisados segundo Geertz, unindo as informações da coleta bibliográfica ao conhecimento dos autores sobre TC e AAAC. Das 100 bibliografias coletadas selecionaram se 40 trabalhos. Ao final, o estudo permitiu reconhecer o TC como um arranjo produtivo capaz de ofertar novas oportunidades de renda aos grupos tradicionais com prestação de serviços de hospedagem, alimentação e lazer em unidades familiares e criar atividades turísticas integradas à proteção ambiental e cultural.
Being gifted in art and music space in Turkey
Authors: Ilhan Ayse Cakir 
Published: October 2019

The gifted individual is an individual whose high performance in terms of intelligence, creativity, art, leadership capacity or academic fields is determined by experts. In the literature, when the individuals constituting the society are examined in terms of intelligence, 95% is considered to be normal, 3% is lowand 2% is superior. The development and progress of countries is only possible with the efficient use of skilled human resources. Three sets of characteristics for gifted children is defined in the study: general and special ability level, creativity and motivation. A workshop was organized by the Turkish Ministry of National Education on 21-22 January 2019 to form an action plan for â€œEducation for Giftedâ€. 76 field experts and trainers participated in the workshop. This paper will discuss opinions relating to the field of arts, found in the report released at the end of the workshop and the current situation in Turkey will be summarized. The data of the descriptive study will be collected based on document review and observation.
Keywords: Art, Art education, Fine arts, gifted children, leadership
Quality and Detergency Optimization, Liquid Detergent Preparation, Mahogany Seed Extract (Swietenia mahagoni)
Authors: Yuliyanti Mela , Husada Vinsensius Maunia Singgih , Fahrudi Halida Anwar Alzundi , Setyowati Widiastuti Agustina Eko 
Published: October 2019

The use of <em>Linear Alkylbenzene Sulfonate</em>(LAS) as a surfactant for making detergent can pollute aquatic ecosystem and agricultural soils. Mahogany seed extract can be used as a substitute for LAS because it contains saponin so that it can be used also as a foaming agent to remove dirt on clothes. This research aims to know the optimum liquid detergent formula seen from its suitability with SNI 06-4075-1996 about Liquid Washing Detergents, foam stability and detergency power. The research steps are (1) Making simplicia (2) Extracting mahogany seeds with ethanol solvent (3) Identification of saponin (4) Making liquid detergent preparations (5) Quality test, foam stability test and detergency power. The results showed that formula 2 with a ratio of mahogany seed extract : LAS is 2 : 1 is the most optimum formula because it appropiate with SNI, and has the best foam stability and detergency power. Formula 2 has pH 11.1; specific gravity 1.1; 0.1% free alkaline, foam stability of 70% and detergency without rinsing 91.53% and by rinsing 94.680%.<pre><em> </em></pre>
Not All Garden-I and II Femoral Neck Fractures in the Elderly Should Be Fixed
Authors: Okike Kanu , Udogwu Ugochukwu N. , Isaac Marckenley , Sprague Sheila , Swiontkowski Marc F. , Bhandari Mohit , Slobogean Gerard P. ,   on behalf of the FAITH Investigators
Published: October 2019

Background:
Internal fixation is currently the standard of care for Garden-I and II femoral neck fractures in elderly patients. However, there may be a degree of posterior tilt (measured on preoperative lateral radiograph) above which failure is likely, and primary arthroplasty would be preferred. The purpose of this analysis was to determine the association between posterior tilt and the risk of subsequent arthroplasty following internal fixation of Garden-I and II femoral neck fractures in elderly patients.

Methods:
This study is a preplanned secondary analysis of data collected in the FAITH (Fixation using Alternative Implants for the Treatment of Hip fractures) trial, an international, multicenter, randomized controlled trial comparing the sliding hip screw with cannulated screws in the treatment of femoral neck fractures in patients ≥50 years old. For each patient who sustained a Garden-I or II femoral neck fracture and had an adequate preoperative lateral radiograph, the amount of posterior tilt was categorized as <20° or ≥20°. Multivariable Cox proportional hazards analysis was used to assess the association between posterior tilt and subsequent arthroplasty during the 2-year follow-up period, controlling for potential confounders.

Results:
Of the 555 patients in the study sample, 67 (12.1%) had posterior tilt ≥20° and 488 (87.9%) had posterior tilt <20°. Overall, 73 (13.2%) of 555 patients underwent subsequent arthroplasty in the 24-month follow-up period. In the multivariable analysis, patients with posterior tilt ≥20° had a significantly higher risk of subsequent arthroplasty compared with those with posterior tilt <20° (22.4% [15 of 67] compared with 11.9% [58 of 488]; hazard ratio, 2.22; 95% confidence interval, 1.24 to 4.00; p = 0.008). The other factor associated with subsequent arthroplasty was age ≥80 years (p = 0.03).

Conclusions:
In this analysis of patients with Garden-I and II femoral neck fractures, posterior tilt ≥20° was associated with a significantly increased risk of subsequent arthroplasty. Primary arthroplasty may be considered for Garden-I and II femoral neck fractures with posterior tilt ≥20°, especially among older patients.

Level of Evidence:
Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Subluxation of the Middle Facet of the Subtalar Joint as a Marker of Peritalar Subluxation in Adult Acquired Flatfoot Deformity
Authors: de Cesar Netto Cesar , Godoy-Santos Alexandre Leme , Saito Guilherme H. , Lintz Francois , Siegler Sorin , O’Malley Martin J. , Deland Jonathan T. , Ellis Scott J. 
Published: October 2019

Background:
Progressive peritalar subluxation (PTS) is part of adult acquired flatfoot deformity (AAFD). We investigated the use of the middle facet as an indicator of PTS using standing, weight-bearing computed tomography (CT) images. We hypothesized that weight-bearing CT would be an accurate method of measuring increased subluxation (“uncoverage”) and incongruence of the middle-facet among patients with AAFD.

Methods:
We included 30 patients with stage-II AAFD (20 female and 10 male; mean age, 57.4 years [range, 24 to 78 years]) and 30 matched controls (20 female and 10 male; mean age, 51.8 years [range, 19 to 81 years]) who underwent standing, weight-bearing CT. Two independent and blinded fellowship-trained foot and ankle surgeons measured the amount of subluxation (percentage of uncoverage) and the incongruence angle of the middle facet at the midpoint of its longitudinal length, using coronal-plane, weight-bearing, cone-beam CT images. Intraobserver and interobserver reliabilities were assessed using intraclass correlation coefficients (ICCs). Comparisons were performed using independent t tests or Wilcoxon tests. P values of <0.05 were considered significant.

Results:
Substantial to almost perfect intraobserver and interobserver reliability was observed for both measurements. We found that the middle facet demonstrated significantly increased PTS in patients with AAFD, with a mean value for joint uncoverage of 45.3% (95% confidence interval [CI], 38.5% to 52.1%) compared with 4.8% (95% CI, 3.2% to 6.4%) in controls (p < 0.0001). A significant difference was also found for the incongruence angle, with a mean value of 17.3° (95% CI, 14.7° to 19.9°) in the AAFD group and 0.3° (95% CI, 0.1° to 0.5°) in controls (p < 0.0001). A joint incongruence angle of >8.4° was found to be diagnostic for symptomatic stage-II AAFD.

Conclusions:
We investigated the use of the middle facet of the subtalar joint as a marker for PTS in patients with AAFD. We confirmed that standing, weight-bearing CT images allowed accurate measurements and that significant differences were found in the percentage of joint uncoverage and the incongruence angle compared with controls.

Clinical Relevance:
The assessment of the amount of subluxation and incongruence of the middle facet of the subtalar joint represents an accurate diagnostic tool for symptomatic adult acquired flatfoot deformity.