bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metallothionein‐1 suppresses rheumatoid arthritis pathogenesis by shifting the Th17/Treg balance
Authors: Sun Jinxia , Li Li , Li Lingyun , Ding Liping , Liu Xiaokai , Chen Xianxiong , Zhang Jinshun , Qi Xin , Du Jing , Huang Zhong 
Published: July 2018

AbstractIt is now well accepted that an imbalance between the Th17 and regulatory T‐cell responses is closely associated with the development of rheumatoid arthritis (RA). However, the precise regulatory mechanism for the differentiation of Th17 and Treg in RA is not well characterized. The present study showed that metallothionein‐1 (MT‐1), which is a low molecular weight protein that is involved in the detoxification of heavy metals and scavenging of free radicals, was upregulated in RA. Furthermore, the synovial inflammation and pathologic symptoms in collagen‐induced arthritis and collagen antibody‐induced arthritis mice were significantly suppressed when MT‐1 was expressed intraarticularly. Further investigation revealed that MT‐1 inhibited the differentiation of Th17 cells but enhanced that of Treg cells. Furthermore, it markedly decreased both STAT3 and RAR‐related orphan receptor gamma t (RORγt) expression in vitro and in vivo. Collectively, our studies demonstrated that MT‐1 might manifest as a protein involved in immunosuppression of RA pathogenesis by shifting Th17/Treg balance and may prove to be a potential therapeutic target for RA autoimmune diseases.
Reduced inhibition in brainstem circuits in classical trigeminal neuralgia
Authors: Gündüz A. , Uygunoğlu U. , Uluduz D. , Saip S. , Siva A. , Göksan B. , Kızıltan M.E. 
Published: July 2018

AbstractObjectiveWe hypothesized that prepulse modulation (PPM) would be altered in trigeminal neuralgia (TN) if suprasegmental inhibitory network involvement was present and tested our hypothesis in a group of patients with classical TN.MethodsThe study enrolled nine consecutive patients with classical TN and 14 healthy subjects. Diagnosis and classification followed the International Classification of Headache Disorders‐third edition (beta version). The blink reflex (BR) and BR‐PPM were recorded. Ipsilateral recordings were made after stimulating each trigeminal nerve in the patient group whereas right‐sided recordings were performed after stimulating the right trigeminal nerve in the healthy subjects. A conditioning electrical stimulus was applied to the ipsilateral median nerve at interstimulus intervals (ISIs) of 50 and 100 ms before the test stimulus to the supraorbital nerve.ResultsThe unconditioned BR recordings were similar in all groups. In the healthy subjects, the prepulse stimulus resulted in a reduced R2 magnitude (p = 0.000, Friedman's test) and longer R2 latency (p = 0.008, Friedman's test) at ISIs of 50 and 100 ms in comparison with unconditioned recordings. The R2 latency differed significantly between the unconditioned recordings and the ISI of 100 ms. In the patients with TN, no significant change was observed on either the symptomatic or asymptomatic sides.ConclusionsThere is a bilateral prepulse inhibition deficit in TN, even on the asymptomatic side. Our findings provide electrophysiological evidence for suprasegmental changes and loss of filtering activity at the brainstem in level TN.
Probing the history of social psychology, exploring diversity and views of the social: Publication trends in the European Journal of Social Psychology from 1971 to 2016
Authors: Rizzoli Valentina , Castro Paula , Tuzzi Arjuna , Contarello Alberta 
Published: July 2018

AbstractThe European Journal of Social Psychology (EJSP), as the voice of the European Association of Social Psychology, aims to promote diversity and a distinctively ‘European’, more ‘social’, social psychology (SP). However, whether and how these objectives have been accomplished over time remains controversial. This article enters this debate, tracing the history of SP as depicted by EJSP publications, via two types of lexicometric analyses of all abstracts of the Journal (1971–2016). Themes, processes, methods, and their organisation in cycles and clusters over time, were identified and analysed. Regarding diversity, findings indicate that the publications reflect several of the new theoretical proposals that emerged over the years, but do not fully reflect the variety of perspectives and methods of the discipline. It further indicates that lately the ‘social’ is predominantly present in attention to pressing social issues, albeit the processes involved in them are mostly theorised at an individualistic level. This pattern suggests the importance of keeping open the quest for epistemological and methodological diversity, and of re‐problematising what the ‘social’ in SP means. By contributing to mapping the history of SP, offering a more comprehensive and reflexive view for it, the present analyses also help in forging a stronger discipline.
Interaction of environmental steroids with organic anion transporting polypeptide (Oatp1d1) in zebrafish (Danio rerio)
Authors: Willi Raffael Alois , Fent Karl 
Published: July 2018

Abstract

Steroid hormones in the aquatic environment may pose a risk to fish health due to their ubiquitous presence and high biological activity. At present, the uptake process and toxicokinetics of steroids in fish are poorly known, in particular the role of cell membrane transporters. We investigated the interaction of 17 endogenous and environmental steroids with the zebrafish organic anion transporting peptide (Oatp1d1) uptake transporter, which is prominently expressed in liver and kidneys. We selected steroids of different classes including androstenedione (A4), progesterone (P4), and its metabolites, as well as glucocorticoids and spironolactone, and analyzed their interaction with Oatp1d1 by competitive inhibition of the uptake of the fluorescent substrate Lucifer Yellow. The half-maximal inhibition (IC50) values derived from sigmoid inhibition curves were lowest for P4, and the order of increasing IC50 values was as follows: 17α-hydroxyprogesterone &gt; clobetasol propionate &gt; spironolactone &gt; 21α-hydroxyprogesterone &gt; fludrocortisone acetate and additional glucocorticoids. The interaction activity showed a positive correlation with the lipophilicity of the steroids. Our data show that different classes of steroids interact with Oatp1d1 with different activity (either by uptake or inhibition, or both). This is of importance, because in consequence, steroids may interfere with the transport of endogenous substrates, and thus physiological processes. Moreover, steroids may alter cellular trafficking of environmental contaminants by competitive inhibition of this transporter. Environ Toxicol Chem 2018;37:2670–2676. © 2018 SETAC
Abstract
Chronic toxicity of 6 neonicotinoid insecticides to Chironomus dilutus and Neocloeon triangulifer
Authors: Raby Melanie , Zhao Xiaoming , Hao Chunyan , Poirier David G. , Sibley Paul K. 
Published: July 2018

Abstract

Neonicotinoid insecticides are frequently detected in surface waters near agricultural areas, leading to a potential for chronic exposure to sensitive aquatic species. The midge Chironomus dilutus and the mayfly Neocloeon triangulifer have been shown to be acutely sensitive to neonicotinoids. Previous studies have established chronic effects of some neonicotinoids on C. dilutus, but reproduction has not been studied. Toxic effects have not been assessed using N. triangulifer. We present the results of chronic, static-renewal tests for 6 neonicotinoids (acetamiprid, clothianidin, dinotefuran, imidacloprid, thiacloprid, and thiamethoxam) with C. dilutus (≤56-d in length) and N. triangulifer (≤32-d in length). Emergence was generally the most sensitive endpoint for both species across all neonicotinoids. Effect concentrations, 10% (EC10s; emergence) were 0.03 to 1.1 μg L−1 for acetamiprid, clothianidin, imidacloprid, and thiacloprid. Dinotefuran and thiamethoxam were less potent, with EC10s (C. dilutus) or median effect concentrations (EC50s; N. triangulifer) of 2.2 to 11.2 μg L−1. Hazard was assessed through comparison of neonicotinoid environmental concentrations from agricultural surface waters in Ontario (Canada) with either the 5th percentile hazard concentration (for imidacloprid) or species-specific EC10s from the present study (for all remaining neonicotinoids). The resulting hazard quotients (HQs) indicated little to no hazard (HQ &lt;1) in terms of chronic toxicity for acetamiprid, dinotefuran, thiacloprid, or thiamethoxam. A moderate hazard (HQ &gt;1) was found for emergence of N. triangulifer for clothianidin, and a high hazard (HQ = 74) was found for imidacloprid. Environ Toxicol Chem 2018;37:2727–2739. © 2018 SETAC
Influence of Diltiazem on Fathead Minnows Across Dissolved Oxygen Gradients
Authors: Saari Gavin N. , Corrales Jone , Haddad Samuel P. , Chambliss C. Kevin , Brooks Bryan W. 
Published: July 2018

Abstract

Water resources in many arid to semi-arid regions are stressed by population growth and drought. Growing populations and climatic changes are influencing contaminant and water chemistry dynamics in urban inland waters, where flows can be dominated by, or even dependent on, wastewater effluent discharge. In these watersheds, interacting stressors such as dissolved oxygen and environmental contaminants (e.g., pharmaceuticals) have the potential to affect fish physiology and populations. Recent field observations from our group identified the calcium channel blocker (CCB) diltiazem in fish plasma exceeding human therapeutic doses (e.g., Cmin) in aquatic systems impaired because of nonattainment of dissolved oxygen water quality standards. Therefore our study objectives examined: 1) standard acute and chronic effects of dissolved oxygen and diltiazem to fish, 2) influences of dissolved oxygen at criteria levels deemed protective of aquatic life on diltiazem toxicity to fish, and 3) whether sublethal effects occur at diltiazem water concentrations predicted to cause a human therapeutic level (therapeutic hazard value [THV]) in fish plasma. Dissolved oxygen × diltiazem co-exposures significantly decreased survival at typical stream, lake, and reservoir water quality standards of 5.0 and 3.0 mg dissolved oxygen/L. Dissolved oxygen and diltiazem growth effects were observed at 2 times and 10 times lower than median lethal concentration (LC50) values (1.7 and 28.2 mg/L, respectively). Larval fathead minnow (Pimephales promelas) swimming behavior following low dissolved oxygen and diltiazem exposure generally decreased and was significantly reduced in light-to-dark bursting distance traveled, number of movements, and duration at concentrations as low as the THV. Individual and population level consequences of such responses are not yet understood, particularly in older organisms or other species; however, these findings suggest that assessments with pharmaceuticals and other cardioactive contaminants may underestimate adverse outcomes in fish across dissolved oxygen levels considered protective of aquatic life. Environ Toxicol Chem 2018;37:2835–2850. © 2018 SETAC
Adhesion and differentiation behaviors of mesenchymal stem cells on titanium with micrometer and nanometer‐scale grid patterns produced by femtosecond laser irradiation
Authors: Chen Peng , Aso Toshihiro , Sasaki Ryuichiro , Ashida Maki , Tsutsumi Yusuke , Doi Hisashi , Hanawa Takao 
Published: July 2018

AbstractTo clarify the effects of grid topographies with different scales on cell morphology and functionalization, we investigated the adhesion and differentiation of human mesenchymal stem cells (hMSCs) to titanium surfaces with micron, nano, and micron/nano (hybrid) grid topographies created by femtosecond laser irradiation. The results showed that cellular adhesion and differentiation strongly depended on the scales of the grid topography. hMSCs cultured on micron and hybrid grid topographies showed regulation of cellular adhesion plaques following the surface topography and were vinculin‐positive, whereas filamentous vinculin was evident at the filopodia of hMSCs cultured on nanogrids. The findings indicate that the micron grid topography was beneficial for cell colonization by anchoring the cells to the substrate surface, whereas the nanogrid topography was beneficial for cell locomotion. With the superposition effect of the micron and nanogrids, micro/nanohybrid grid topography strongly promoted cell adhesion. This differential adhesion induced differences cell differentiation. Nanogrids promoted differentiation of hMSCs, particularly osteogenic differentiation. These findings provide a basis for the design of novel biomaterial surfaces that can regulate specific cellular functions. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2735–2743, 2018.
ZIF‐8@SiO2 core–shell microsphere extraction coupled with liquid chromatography and triple quadrupole tandem mass spectrometry for the quantitative analysis of four plant growth regulators in navel oranges
Authors: Xu Xiaomei , Wang Xiaofen , Liu Menghan , Tan Ting , Wan Yiqun 
Published: July 2018

AbstractMonodisperse silica spheres that comprised a rhombic‐dodecahedral zeolitic imidazolate framework core–shell microsphere were applied in the sample pretreatment of navel orange. A rapid and efficient liquid chromatography with triple quadrupole tandem mass spectrometry method was established for simultaneously quantifying four plant growth regulators, 6‐benzylaminopurin, indole‐3‐acetic acid, indolepropionic acid, 3‐indolebutyric acid, in navel oranges. A satisfactory result was obtained, i.e., the peak area of the four plant growth regulators against concentration was linear with good correlation coefficients of 0.99987–0.99991. Under optimized conditions, the limits of detection were 3.0–59.4 μg/L for the four plant growth regulators. This method was applied to the simultaneous analysis of the four plant growth regulators in commercial samples, and all the detections were confirmed by acquiring transitions for each pesticide in the samples.
Dual‐frame lek surveys for estimating greater sage‐grouse populations
Authors: Shyvers Jessica E. , Walker Brett L. , Noon Barry R. 
Published: July 2018

ABSTRACTEffective monitoring programs are important for ensuring proper management of wildlife populations, but they require substantial resources, effort, and funding. For this reason, managers often use indices of animal abundance. However, indices typically rely on untested assumptions and may be unreliable for estimating population size, status, and trend. Therefore, it is important to test the assumptions underlying indices and to evaluate more rigorous methods of population estimation. Counts of males at leks are used as an index to monitor populations of greater sage‐grouse (Centrocercus urophasianus), a species of conservation concern, throughout its range in the western United States and Canada. However, not all leks are known, and wildlife managers typically have no rigorous, quantitative estimates of the number of leks and males in any given population. Therefore, it remains unclear what proportion of leks and males are included in, or excluded from, lek‐based population status assessments, trend analyses, and management decisions. We used dual‐frame surveys, in combination with occupancy analysis to adjust for imperfect detection, to estimate the number of active leks, the number of lekking males, and the proportion of active leks and lekking males counted on annual lek surveys over 3 consecutive breeding seasons in a small, low‐density greater sage‐grouse population in northwestern Colorado, USA. We estimated that annual lek surveys captured an average of 45–74% of active leks and 43–78% of lekking males each year. Our results suggest that many active leks remain unknown and annual counts fail to account for a substantial, but variable, proportion of the number of active leks and lekking males in the population in any given year. Managers need to recognize this potential source of bias in lek‐count data and, if possible, account for it in trend analyses and management efforts. Increased cost likely precludes annual use of dual‐frame lek surveys. However, we recommend using analytical methods that account for imperfect detection, mapping potential lek habitat to improve survey efficiency, and conducting dual‐frame surveys over multiple years to better understand temporal variation in the proportion of active greater sage‐grouse leks and lekking males being counted in specific populations of interest. © 2018 The Wildlife Society.
Hierarchical mark‐recapture distance sampling to estimate moose abundance
Authors: Oyster Jared H. , Keren Ilai N. , Hansen Sara J.K. , Harris Richard B. 
Published: July 2018

ABSTRACTEstimating the abundance of wide‐ranging wildlife, difficult under any circumstances, is particularly challenging when detection is low and affected by factors that also influence density and distribution. In northeastern Washington, moose (Alces alces) have evidently increased since the 1970s but spend most of their time under coniferous cover that makes detection from the air difficult. We used a Bayesian hierarchical approach to incorporate habitat use (in the form of availability as a function of canopy closure) into a detection model within a mark‐recapture distance sampling framework to estimate moose density. Our model of availability used a latent density surface employing habitat use data obtained from 17 adult female moose wearing global positioning system (GPS) collars. Distance sampling data, obtained from helicopter surveys in winters 2014, 2015, and 2016, consisted of double‐observer detections of 166 moose groups along 2,241 km of systematically placed line transects within 29 survey blocks selected using a stratified‐random design. We estimated moose density over the entire survey area as 0.49/km2(95% credible interval = 0.33–0.67/km2). Extrapolated to the 10,513‐km2survey area, we estimated 5,169 moose (95% credible interval = 3,510–7,034). Our methodology allowed us to adjust for availability bias and produce an estimate even where detection was difficult but required many hours of helicopter flights, acceptable weather conditions, and the availability of GPS collared‐moose. © 2018 The Wildlife Society.
Recent Advances in Resonant Waveguide Gratings
Authors: Quaranta Giorgio , Basset Guillaume , Martin Olivier J. F. , Gallinet Benjamin 
Published: July 2018

AbstractResonant waveguide gratings (RWGs), also known as guided mode resonant (GMR) gratings or waveguide‐mode resonant gratings, are dielectric structures where these resonant diffractive elements benefit from lateral leaky guided modes from UV to microwave frequencies in many different configurations. A broad range of optical effects are obtained using RWGs such as waveguide coupling, filtering, focusing, field enhancement and nonlinear effects, magneto‐optical Kerr effect, or electromagnetically induced transparency. Thanks to their high degree of optical tunability (wavelength, phase, polarization, intensity) and the variety of fabrication processes and materials available, RWGs have been implemented in a broad scope of applications in research and industry: refractive index and fluorescence biosensors, solar cells and photodetectors, signal processing, polarizers and wave plates, spectrometers, active tunable filters, mirrors for lasers and optical security features. The aim of this review is to discuss the latest developments in the field including numerical modeling, manufacturing, the physics, and applications of RWGs. Scientists and engineers interested in using RWGs for their application will also find links to the standard tools and references in modeling and fabrication according to their needs.
A literature review and meta‐analysis of outcomes in microsurgical reconstruction using vasopressors
Authors: Knackstedt Rebecca , Gatherwright James , Gurunluoglu Raffi 
Published: July 2018

IntroductionThere is a hesitancy to utilize vasopressors in microsurgical reconstruction due to fear of vessel spasm and subsequent flap compromise. Although there are large literature reviews analyzing vasopressor usage in head and neck reconstruction, this has not been extrapolated to all regions of the body. The goal of this study was to perform a meta‐analysis examining vasopressor usage and risk of complications in microsurgical reconstruction for all recipient sites.Materials and MethodsA meta‐analysis was conducted for articles discussing the utilization of vasopressors in microsurgical reconstruction. The primary endpoint was total flap failure. Secondary endpoints were necessity for operative take‐back and hematoma requiring intervention. Odds ratios were calculated for each complication and for each study.ResultsFour prospective and six retrospective studies were analyzed yielding 6321 patients and 7526 flaps. 67.4% (966/1433) of patients received vasopressors and 80.8% (6080/7526) of flaps received vasopressors. There were 100 failures in the vasopressor group (100/6080 = 15.9%) and 39 failures in the non‐vasopressor group (39/1456 = 26.8%) (O.R. 0.73; p = 0.12). There were 177 take‐backs in the vasopressor group (177/5916 = 29.9%) and 64 take‐backs in the non‐vasopressor group (64/1404 = 4.6%) (O.R. 0.65; p < 0.05). There were 73 hematomas in the vasopressor group (73/5099 = 14/3%) and 14 hematomas in the non‐vasopressor group (14/979 = 14.3%) (O.R. 1; p = 0.89). The odds ratio for total flaps failures in the breast and head/neck cohorts were 0.788 (p = 0.76) and 1.2761 (p = 0.77), respectively, with neither significantly increased in flaps receiving vasopressors.ConclusionOur results suggest that vasopressor utilization does not directly result in increased complications. Flaps that received vasopressors had a statistically lower rate of take‐back and failure. Due to the paucity of data available for analysis and limited reporting relating flap characteristics to outcomes, prospective, well‐designed studies are necessary to verify the safety of vasopressor use in microsurgical reconstruction.
Translation, cross‐cultural adaptation, and validation of the chinese version of the 15‐item myasthenia gravis quality of life questionnaire
Authors: Miao Xiaohui , Lian Zhiyun , Liu Ju , Chen Hongxi , Shi Ziyan , Li Mier , Zhou Hongyu , Hu Xiuying , Yang Rong 
Published: July 2018

ABSTRACTIntroduction: We sought to translate, cross‐culturally adapt, and evaluate the internal consistency and validity of the Chinese version of the 15‐Item Myasthenia Gravis Quality of Life (MG‐QOL15). Methods: Translation and cross‐cultural adaptation of the MG‐QOL15 were performed. We used Cronbach's α to test internal consistency, one‐way analysis of variance to test construct validity, and Pearson or Spearman correlations to test discriminant and concurrent validity. Results: We enrolled 168 outpatients. Internal consistency was excellent (Cronbach's α = 0.928). The MG‐QOL15 discriminated MG severity as stratified by the MG Composite (MGC; P < 0.001) and Osserman class (P = 0.01). Concurrent validity was low to moderate with the subscales of the 36‐item Short Form (−0.31 to ∼−0.59), MGC (r = 0.46), and Myasthenia Gravis Activities of Daily Living profile (r = 0.54). Discussion: The Chinese MG‐QOL15 showed comparable construct, discriminant and concurrent validity, and internal consistency with to the original version. Muscle Nerve 59:95–99, 2019