bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revealing Yukon’s hidden treasure: an atomic-scale investigation of Carlin-type gold mineralization in the Nadaleen Trend, Canada
Authors: Gopon Phillip , Sack Patrick , Pinet Nicolas , Douglas James O. , Jenkins Benjamin M. , Johnson Brooke , Penny Ella , Moody Michael P. , Robb Laurence 
Published: October 2024

AbstractThe invisible-gold deposits known as Carlin-type are becoming more important as easier to find deposits are progressively depleted. The combination of the invisible nature of the Au in these deposits, as well as the limited surface indicators of these deposits, makes exploration to find new Carlin-type deposits extremely difficult. Comprehensive mineralization models are essential to find new Carlin-type deposits in similar geologic settings. The Nadaleen Trend of Yukon, Canada, is one such district where an improved understanding of this deposit type has led to new discoveries. Previous studies compared and contrasted the tectonic setting, host rock depositional setting, structural preparation, and mineralization style of the Nadaleen Trend with those in Carlin-type localities, Nevada. However, the comparisons at an atomic scale, between Carlin-type Au deposits in the Nadaleen Trend and those in Nevada, has yet to be investigated. This study fills this knowledge gap by combining high resolution microanalytical techniques with atom probe tomography to examine the distribution of Au and other trace elements in the Nadaleen Trend, compare them to a representative Carlin-type deposit in Nevada (Turquoise Ridge), and determine how widespread the mineralization model is. Our findings show that in the Nadaleen Trend, as in Nevada, Au is generally directly linked with As at the macro to atomic scale, and is incorporated into As/Au rich overgrowths on sedimentary/diagenetic pyrite. Gold-rich pyrite rims in the Nadaleen Trend are generally smaller than those found in Nevada (0.5–2 µm vs > 10 µm), although the ore grades appear comparable. We find that the Au in the pyrite of the Nadaleen Trend is homogenously distributed (i.e. lattice bound) at the atomic scale, but that there is a notable enrichment of As surrounding individual Au atoms. These findings are in agreement with those from previous work on a representative deposit in Nevada, and support the assertation that As is the key ingredient in facilitating the incorporation of Au into the pyrite lattice. Arsenic as an essential component in the trapping mechanisms of Au in CTG deposits, is something that has been as to yet underappreciated in the current models of CTG deposit formation.
Investment casting of porous Mg-alloy networks biomechanically tuned for bone implant applications
Authors: Dmitruk Anna , Díaz Lantada Andrés , Ferraris Sara , Łobacz-Raźny Natalia , Spriano Silvia , Naplocha Krzysztof 
Published: October 2024

AbstractManufacturing technology has been refined and described for the fabrication of honeycomb-based bioresorbable networks for temporal bone replacement applications. Two novel techniques, digital light processing and investment casting, were utilized to produce customized, shape-optimized cellular constructs with additional orifices promoting tissue ingrowth during osteo-regeneration. For this purpose, a conventional magnesium casting alloy (AZ91) was chosen. Numerical simulations were conducted to predict the compressive behavior of the proposed biodegradable lightweight scaffolds. Spatial castings were adjusted to possess mechanical properties comparable to the ones of cortical or trabecular bones. Two kinds of protective coatings (plasma electrolytic oxidation and organic ones based on natural polyphenols from tea extract) were deposited and characterized. They can be utilized to control the degradation rate during exploitation to achieve a predictable implant lifespan. The elaborated layers aim to mitigate the rapid corrosion of magnesium substrates by prolonging their bioresorption time and thus expanding their applicability in osseointegration. To evaluate this assumption, immersion tests in phosphate-buffered saline were performed, showing better chemical resistance of PEO coating and as-cast sample (for both mass gain by below 1%), and visible increase in mass of sample coated with organic coating (increase by almost 5%). Compressive strength results from numerical approach were further validated by experimental compression tests, showing that PEO coating deteriorated compressive strength by almost 3%, and organic coating improved it by over 9%. Results achieved in numerical approach were better than expected for stiffer sample, and slightly lower for the one with bigger pores.
Prostate cancer lesions in transition zone exhibit a higher propensity for pathological upgrading in radical prostatectomy
Authors: Chen Xin , Wang He , Wang Chaozhong , Qian Chengbo , Lin Yuxin , Huang Yuhua , Wei Xuedong , Hou Jianquan 
Published: October 2024

Abstract
Background
The varying malignancy and lethality of different grades of prostate cancer (PCa) highlight the importance of accurate diagnosis. This study aims to evaluate the upgrading of transition zone (TZ) prostate cancer biopsies and identify factors to improve TZ biopsy accuracy.

Materials and methods
This retrospective study included 217 patients who underwent laparoscopic radical prostatectomy after 12 + X cores transperineal transrectal ultrasound-magnetic resonance imaging (MRI)-guided targeted prostate biopsy from 2018 to 2021 in our center.

Results
Patients with TZ lesions showed a higher incidence of International Society of Urological Pathology (ISUP) grade upgrading from 1 to higher grade compared to peripheral zone lesions (16.9% vs. 5.0%, p = 0.005). Multivariate analysis confirmed TZ lesions as an independent risk factor (OR: 4.594, 97.5% CI: 1.569–15.238, p = 0.008) for upgrading from 1 to higher. Additionally, the number of positive biopsy cores (OR: 0.586, 97.5% CI: 0.336–0.891, p = 0.029) and anterior TZ lesion location (OR: 10.797, 97.5% CI: 1.503-248.727, p = 0.048) were independent factors for the upgrading in TZ patients.

Conclusions
This study found that PCa lesions located in the TZ, particularly the anterior TZ, have a higher risk of ISUP grade upgrading. This elevated risk arises from the insufficient distribution of biopsy cores around the TZ lesion. The findings underscore the importance of having an adequate number of biopsy cores around the lesion area to improve the accuracy of ISUP grade assessments.
Postoperative complications in patients with Behçet’s disease
Authors: Jung You Jin , Park Eun Hye , Kim Ju Yeon , Lee Eun Kyoung , Choi Yunhee , Lee Eun Bong 
Published: October 2024

Abstract
Objective
To assess the proportion of postoperative complications of various surgeries in patients with Behçet’s disease (BD) and compare the risk of surgical complications between BD patients and controls.

Methods
We analyzed 389 BD patients who underwent surgeries at Seoul National University Hospital between January 2003 and December 2019. Controls were 1:1 matched with BD patients based on age at surgery, sex, and type of surgery. Generalized estimating equation analyses were performed to compare the postoperative complications between BD patients and controls.

Results
Among 632 surgeries in BD patients, 36 (5.7%) surgical site complications, including wound dehiscence (38.9%), bleeding (13.9%), infections (8.3%), anastomotic dehiscence (22.2%), and stricture (5.6%), occurred after median 12 days (IQR 7.8–22.0). Surgical site complications developed frequently after cardiac (33.3%) and vascular (22.2%) surgeries and rarely occurred after ophthalmic (1.5%) surgeries. Seventeen (2.7%) cases required reoperation within median 15 days (IQR 7.0–43.0). Four patients died within median 21 days (IQR 8.3–41.3 days). After adjustment for confounders, BD patients exhibited a significantly higher risk of surgical site complications (OR 3.4, 95% CI 1.4–8.0) and reoperation (OR 5.2, 95% CI 1.2–22.8) after cardiovascular surgery than controls. However, the risks of surgical site complications and reoperation after other types of surgery were similar in both groups.

Conclusions
The risk of postoperative complications varies according to the type of surgeries among BD patients. While cardiovascular surgeries result in higher perioperative complications in BD patients, ophthalmic surgeries show a safety profile similar to those in non-BD patients.

Key Points• Patients with Behçet’s disease exhibited an increased risk of surgical site complications and subsequent reoperations after cardiovascular surgery than controls.• The safety profile of ophthalmic surgery was comparable between patients with Behçet’s disease and controls.• In patients with Behçet’s disease, the risk of postoperative complications varies according to the type of surgery.
Impact of age on surgical outcomes for world federation of neurosurgical societies grade I and II aneurysmal subarachnoid haemorrhage: a novel prognostic model using recursive partitioning analysis
Authors: Umekawa Motoyuki , Yoshikawa Gakushi 
Published: October 2024

AbstractThis study aimed to evaluate age as a prognostic factor and develop a comprehensive prognostic model for patients undergoing clipping surgery for World Federation of Neurosurgical Societies (WFNS) grade I/II aneurysmal subarachnoid haemorrhage (SAH). We retrospectively investigated 188 patients with WFNS grade I/II SAH who underwent microsurgical clipping at our institute between December 2010 and January 2020. The data of 176 patients (75 with grade I and 101 with grade II) were analysed. Data on patient demographics, aneurysm characteristics, SAH factors, surgical details, and clinical outcomes were collected. Prognostic factors were assessed using bivariate and multivariable logistic regression analyses, and recursive partitioning analysis. Favourable outcomes (mRS 0–2) were observed in 76% of patients. Age, a significant negative prognostic factor in multivariable analysis (odds ratio 0.55, 95% confidence interval 0.40–0.76, p < 0.001), was cutoff at 70 years by the receiver operating characteristic curve. Patients aged ≤ 70 years had significantly better outcomes than those aged > 70 years (84% vs. 46%, respectively; p < 0.001). Epileptic seizures were significantly associated with poor outcomes in older adults (p < 0.001). A prognostic model (favourable, intermediate, and poor) based on age and postoperative adverse events showed significantly different outcomes between age groups (p < 0.001). Age was a stronger prognostic factor than WFNS grading for patients with grade I/II SAH undergoing microsurgical clipping. For patients aged ≤ 70 years, precise microsurgeries with fewer complications were associated with favourable outcomes beyond WFNS grade. For older patients, postoperative intensive seizure management may prevent poor outcomes.
A review of time-series analysis for cyber security analytics: from intrusion detection to attack prediction
Authors: Landauer Max , Skopik Florian , Stojanović Branka , Flatscher Andreas , Ullrich Torsten 
Published: October 2024

Abstract
Understanding the current threat landscape as well as timely detection of imminent attacks are primary objectives of cyber security. Through time-series modeling of security data, such as event logs, alerts, or incidents, analysts take a step towards these goals. On the one hand, extrapolating time-series to predict future occurrences of attacks and vulnerabilities is able to support decision-making and preparation against threats. On the other hand, detection of model deviations as anomalies can point to suspicious outliers and thereby disclose cyber attacks. However, since the set of available techniques for time-series analysis is just as diverse as the research domains in the area of cyber security analytics, it can be difficult for analysts to understand which approaches fit the properties of security data at hand. This paper therefore conducts a broad literature review in research domains that leverage time-series analysis for cyber security analytics, with focus on available techniques, data sets, and challenges imposed by applications or feature properties. The results of our study indicate that relevant approaches range from detective systems ingesting short-term and low-level events to models that produce long-term forecasts of high-level attack cases.
The European energy crisis and the US natural gas market dynamics: a structural VAR investigation
Authors: Rubaszek Michał , Szafranek Karol 
Published: October 2024

Abstract
The Russian invasion of Ukraine triggered severe disruptions in the European energy market, causing also significant shifts in global natural gas flows. We investigate how this European shock has affected the dynamics and altered the estimates of the elasticities on the US natural gas market. We use the Bayesian Structural Vector Autoregression framework proposed by Baumeister and Hamilton (Am Econ Rev 109(5):1873–1910, 2019, BH) for the crude oil market and applied by Rubaszek et al. (Energy Econ 103:105526, 2021, RSU) to analyze the dynamics of the US natural gas market. By extending the RSU model for natural gas exports and imports and deriving model’s posterior using most recent data, we approximate the impact of the European energy crisis on the US natural gas market. We show that the estimates of the US natural gas market elasticities change due to our modification, while simply updating the same prior beliefs with most recent data impacts the posterior estimates to a very limited extent. We also find that a shock even as major as the European energy crisis has only marginally affected the US natural gas market, thus confirming the results from the literature that the EU and US natural gas markets evolve independently.
Lattice Fundamental Measure Theory Beyond 0D Cavities: Dimers on Square Lattices
Authors: Zimmermann Michael , Oettel Martin 
Published: October 2024

AbstractUsing classical density functional theory, we study the behavior of dimers, i.e. hard rods of length $$L=2$$

L
=
2

, on a two-dimensional cubic lattice. For deriving a free energy functional, we employ Levy’s prescription which is based on the minimization of a microscopic free energy with respect to the many-body probability under the constraint of a fixed density profile. Using that, we recover the "0D cavity" functional originally found by Lafuente and Cuesta and derive an extension by applying a more general "cluster density functional theory" method introduced by Lafuente and Cuesta as well. Moreover, we introduce a new free energy functional, which is based on approximated configurational probabilities. Both derived free energy functionals are exact on cavities that can hold at most two particles simultaneously. The first functional allows to improve the prediction of the free energy in bulk and both of them improve the prediction in highly confined systems, especially for high packing fractions, in comparison to the "0D cavity" functional.
Luigi Lugiato’s “Madmen, deranged, criminals”: Dostoevsky and Italian psychiatry after Cesare Lombroso
Authors: Ghidini Maria Candida 
Published: October 2024

AbstractThis essay provides an exploration of the intertwining realms of psychiatry and literature, focusing particularly on the case of Fyodor Dostoevsky. The paper gives an overview of the interest in Dostoevsky’s opus and biography displayed by Italian psychiatry, in particular by Cesare Lombroso and the connection he made between genius and mental illness. The essay is divided into two parts: the first, more theoretical, aims to address the question of the osmosis between psychiatry and literature, paying particular attention to the fact that, in the last twenty years of the nineteenth century, this osmosis seems to have centered mainly around Dostoevsky. The first section delves into the theoretical underpinnings of this intersection, highlighting the influence of figures like Cesare Lombroso and the attraction Dostoevsky’s works and biography held for psychiatrists and alienists. The second section examines Luigi Lugiato’s unpublished study on Dostoevsky. Luigi Lugiato (1879-1950), an Italian psychiatrist and alienist, is a perfect example to demonstrate how decades following Lombroso’s death and notwithstanding all the polemics and critiques surrounding his theories, his strong positivist paradigm continues to shape psychiatric analysis and remains influential in the European cultural panorama. The “law of contradiction”, observed in Dostoevsky’s works and life, permeates Lugiato’s own examination of the author.
Divergent trajectories of Arctic change: Implications for future socio-economic patterns
Authors: Tingstad Abbie , Van Abel Kristin , Bennett Mia M. , Winston Isabelle , Brigham Lawson W. , Stephenson Scott R. , Wilcox Margaret , Pezard Stephanie 
Published: October 2024

Abstract
Climate change is causing rapid warming in the Arctic, which, alongside other physical, socio-economic, cultural, geopolitical, and technological factors, is driving change in the far north. This research presents a conceptual model summarizing Arctic change factors which in turn was used in the design of a Delphi exercise which leveraged a variety of experts to forecast trajectories in different parts of the Arctic. Based on these experts’ expectations for economic and governance outcomes by 2050, we find that our results illustrate the “many Arctics” concept or some of the ways in which the Arctic is heterogenous now, and perhaps becoming increasingly so in the future. Sub-regions of the Arctic differed in expert expectations about the future of resource extraction, tourism, Indigenous self-determination, and military activity, among other outcomes. This work also discusses the post-2022 geopolitical situation and some potential implications of “many Arctics” for policy and future governance.
Gefühlt rechts
Authors: Kempke Kevin 
Published: October 2024

Zusammenfassung
In neurechten Reflexionen über das Lesen werden die Bildung und die Lektürefähigkeit der eigenen Szenemitglieder immer wieder krisenhaft verhandelt. Der Beitrag analysiert die Funktionen solcher ›Lesekrisen‹-Narrative und zeigt auf, in welchem Zusammenhang diese Thematisierungen mit den jeweils entwickelten Literaturkonzepten stehen. Ein Fokus liegt dabei auf dem Jungeuropa-Podcast Von rechts gelesen, der in Abgrenzung von dem in der Neuen Rechten hegemonialen Kubitschek-Kreis eine eigene, dezidiert als ›jung‹ markierte Programmatik entwirft. Das wird besonders an den jeweils unterschiedlichen affektiven Begründungen und Aufladungen der Lektüren verdeutlicht.
Yield curve extrapolation with machine learning
Authors: Akiyama Shinobu , Matsuyama Naoki 
Published: October 2024

AbstractYield curve extrapolation to unobservable tenors is a key technique for the market-consistent valuation of actuarial liabilities required by Solvency II and forthcoming similar regulations. Since the regulatory method, the Smith–Wilson method, is inconsistent with observable yield curve dynamics, parsimonious parametric models, the Nelson–Siegel model and its extensions, are often used for yield curve extrapolation in risk management. However, it is difficult for the parsimonious parametric models to extrapolate yield curves without excessive volatility because of their limited ability to represent observed yield curves with a limited number of parameters. To extend the representational capabilities, we propose a novel yield curve extrapolation method using machine learning. Using the long short-term memory architecture, we achieve purely data-driven yield curve extrapolation with better generalization performance, stability, and consistency with observed yield curve dynamics than the previous parsimonious parametric models on US and Japanese yield curve data. In addition, our method has model interpretability using the backpropagation algorithm. The findings of this study prove that neural networks, which have recently received considerable attention in mortality forecasting, are useful for yield curve extrapolation, where they have not been used before.
Multifaceted implementation strategy to improve the evaluation of penicillin allergies in perioperative patients: a pre-post feasibility implementation study
Authors: Carter Eileen J. , Zavez Katherine , Schramm Carol , Zolla Meagan M. , Baron Katelyn , Banach David B. 
Published: October 2024

AbstractObjective:The U.S. Centers for Disease Control and Prevention encourages nurses to evaluate penicillin allergies as part of hospital-based antibiotic stewardship programs. We evaluated the feasibility of an implementation strategy to improve nurses’ comprehensive documentation of penicillin allergies. We defined feasibility as the uptake and acceptability of documentation procedures.Design:Six-month pre-post feasibility implementation study.Setting:Outpatient surgical areas of an academic medical center located in the U.S.Intervention:The implementation strategy was guided by the Capability, Opportunity, Motivation Model for Behavior Change and included, building an interdisciplinary coalition to iteratively evaluate the implementation effort, educational meetings with surgical prescribers and perioperative nurses, the development and distribution of educational pocket cards, and structured communication messages in the electronic medical record.Results:A total of 426 patients with 487 penicillin allergy records (216 records pre-implementation period, 271 records post-implementation period) were analyzed. Penicillin allergy documentation contained the following information in the pre- versus post-implementation period: symptoms of the reaction (87% vs 87%), timing/years since reaction (8% vs 26%), onset of reaction in relation to taking penicillin (0% vs 21%), how symptoms resolved (0% vs 21%), and penicillin re-exposure (3% vs 21%). Focus groups revealed nurses perceived documentation procedures as highly acceptable. Major drivers of acceptability included the perceived effectiveness of a detailed allergy history and self-efficacy in conducting a detailed allergy history.Conclusions:Nurses perceived the comprehensive documentation of penicillin allergy history intervention as acceptable, and uptake improved following a theory-informed implementation strategy. We offer implementation strategy components to facilitate nurses’ engagement in penicillin allergy evaluation.
Operationalizing an adverse event detection surveillance system to support antimicrobial stewardship activities: perceptions and insights from the SHEA research network
Authors: Al Lawati Hawra J. , Harvey Kimberly L. , Shin Marlena , Mull Hillary , Lamkin Rebecca P. , Golenbock Samuel , Basnet-Thapa Dipandita , Strymish Judith M. , Lee Matthew , Gold Howard , Bidwell Goetz Matthew , Branch-Elliman Westyn 
Published: October 2024

AbstractA surveillance system for measuring patient-level antimicrobial adverse drug events (ADE) may support stewardship activities, however, design and implementation questions remain. In this national survey, stewardship experts favored simple, laboratory-based ADE definitions although there were tensions between feasibility, ability to identify attribution without chart review, and importance of specific ADE.