bluuebunny/crossref_metadata_2025_split huggingface dataset:
A low insertion loss low-pass filter based on single comb-shaped spoof surface plasmon polaritons
Authors: Li Luping , Dong Lijuan , Chen Peng , Yang Kai 
Published: May 2019

AbstractThis paper presents a low insertion loss low-pass filter based on the spoof surface plasmon polariton (SSPP) with single comb-shape. Compared with traditional ones, the proposed filter provides lower insertion loss and return loss by optimizing the structural parameters of the mode conversion and SSPP parts. According to the measurement results, the average insertion loss of the fabricated filter is 0.41 dB and the return loss of which at the near-zero-hertz band is &lt;−25.9 dB. The S parameter comparison result between the unoptimized and optimized filters demonstrates that the optimized filter provides lower insertion loss and return loss, smaller size, and better out-of-band rejection. The dispersion comparison result reveals the reasons behind the improved performances. The better performances of the optimized filter proves that breaking the regularity of traditional SSPP filters is beneficial to the filter's performances.
Subglacial Geology and Geomorphology of the Pensacola‐Pole Basin, East Antarctica
Authors: Paxman Guy J. G. , Jamieson Stewart S. R. , Ferraccioli Fausto , Jordan Tom A. , Bentley Michael J. , Ross Neil , Forsberg René , Matsuoka Kenichi , Steinhage Daniel , Eagles Graeme , Casal Tania G. 
Published: May 2019

AbstractThe East Antarctic Ice Sheet (EAIS) is underlain by a series of low‐lying subglacial sedimentary basins. The extent, geology, and basal topography of these sedimentary basins are important boundary conditions governing the dynamics of the overlying ice sheet. This is particularly pertinent for basins close to the grounding line wherein the EAIS is grounded below sea level and therefore potentially vulnerable to rapid retreat. Here we analyze newly acquired airborne geophysical data over the Pensacola‐Pole Basin (PPB), a previously unexplored sector of the EAIS. Using a combination of gravity and magnetic and ice‐penetrating radar data, we present the first detailed subglacial sedimentary basin model for the PPB. Radar data reveal that the PPB is defined by a topographic depression situated ~500 m below sea level. Gravity and magnetic depth‐to‐source modeling indicate that the southern part of the basin is underlain by a sedimentary succession 2–3 km thick. This is interpreted as an equivalent of the Beacon Supergroup and associated Ferrar dolerites that are exposed along the margin of East Antarctica. However, we find that similar rocks appear to be largely absent from the northern part of the basin, close to the present‐day grounding line. In addition, the eastern margin of the basin is characterized by a major geological boundary and a system of overdeepened subglacial troughs. We suggest that these characteristics of the basin may reflect the behavior of past ice sheets and/or exert an influence on the present‐day dynamics of the overlying EAIS.
An Approach to Modeling Biofilm Growth During the Flocculation of Suspended Cohesive Sediments
Authors: Shen Xiaoteng , Toorman Erik A. , Lee Byung Joon , Fettweis Michael 
Published: May 2019

AbstractThe floc size distribution (FSD) is crucial to predict cohesive sediment dynamics in aquatic environments. Recently, increasing attention has been given to biofilm effects on the FSDs of suspended particles since the presence of biofilms on particle surfaces may lead to larger flocs and thus higher settling velocities. In this study, results from a settling column experiment conducted by Tang and Maggi (2018; https://doi.org/10.1002/2017JG004165) under nutrient‐free and biomass‐free, nutrient‐affected and biomass‐free, and nutrient‐affected and biomass‐affected conditions, with different suspended sediment concentrations, shear rates, and nutrient concentrations, have been used to validate modeled FSDs that is based on the population balance equation solved by the quadrature method of moments. In addition to the processes of aggregation and breakage, the effects of biofilm are expressed in the growth term of the population balance equation. The logistic growth pattern is used to account for an increase in biomass, which is primarily controlled by the specific growth rate and the carrying capacity. In this study, the biofilm growth rate is assumed nutrient dependent, and the carrying capacity of floc size is hypothesized to be proportional to the Kolmogorov microscale. With eight size classes to interpret a simulated FSD, the predicted and observed FSDs exhibit a reasonable match for all nutrient‐free and biomass‐free, nutrient‐affected and biomass‐free, and nutrient‐affected and biomass‐affected conditions. This simplified bioflocculation model fills the gap between the simulations of the FSDs of cohesive sediments without and with biofilms and has the potential to be included in large‐scale models in the future.
The Pressure and Temperature Limits of Likely Rocky Exoplanets
Authors: Unterborn C. T. , Panero W. R. 
Published: May 2019

AbstractThe interior composition of exoplanets is not observable, limiting our direct knowledge of their structure, composition, and dynamics. Recently described observational trends suggest that rocky exoplanets, that is, planets without significant volatile envelopes, are likely limited to <1.5 Earth radii. We show that given this likely upper limit in the radii of purely rocky super‐Earth exoplanets, the maximum expected core‐mantle boundary pressure and adiabatic temperature are relatively moderate, 630 GPa and 5000 K, while the maximum central core pressure varies between 1.5 and 2.5 TPa. We further find that for planets with radii less than 1.5 Earth radii, core‐mantle boundary pressure and adiabatic temperature are mostly a function of planet radius and insensitive to planet structure. The pressures and temperatures of rocky exoplanet interiors, then, are less than those explored in recent shock‐compression experiments, ab initio calculations, and planetary dynamical studies. We further show that the extrapolation of relevant equations of state does not introduce significant uncertainties in the structural models of these planets. Mass‐radius models are more sensitive to bulk composition than any uncertainty in the equation of state, even when extrapolated to terapascal pressures.
Greenhouse Gas Concentration and Volcanic Eruptions Controlled the Variability of Terrestrial Carbon Uptake Over the Last Millennium
Authors: Zhang Xuanze , Peng Shushi , Ciais Philippe , Wang Ying‐Ping , Silver Jeremy D. , Piao Shilong , Rayner Peter J. 
Published: May 2019

AbstractThe terrestrial net biome production (NBP) is considered as one of the major drivers of interannual variation in atmospheric CO2 levels. However, the determinants of variability in NBP under the background climate (i.e., preindustrial conditions) remain poorly understood, especially on decadal‐to‐centennial timescales. We analyzed 1,000‐year simulations spanning 850‐1,849 from the Community Earth System Model (CESM) and found that the variability in NBP and heterotrophic respiration (RH) were largely driven by fluctuations in the net primary production (NPP) and carbon turnover rates in response to climate variability. On interannual to multidecadal timescales, variability in NBP was dominated by variation in NPP, while variability in RH was driven by variation in turnover rates. However, on centennial timescales (100‐1,000 years), the RH variability became more tightly coupled to that of NPP. The NBP variability on centennial timescales was low, due to the near cancellation of NPP and NPP‐driven RH changes arising from climate internal variability and external forcings: preindustrial greenhouse gases, volcanic eruptions, land use changes, orbital change, and solar activity. Factorial experiments showed that globally on centennial timescales, the forcing of changes in greenhouse gas concentrations were the largest contributor (51%) to variations in both NPP and RH, followed by volcanic eruptions impacting NPP (25%) and RH (31%). Our analysis of the carbon‐cycle suggests that geoengineering solutions by injection of stratospheric aerosols might be ineffective on longer timescales.
Calibration of Sr/Ca, Li/Mg and Sr‐U Paleothermometry in Branching and Foliose Corals
Authors: Ross Claire L. , DeCarlo Thomas M. , McCulloch Malcolm T. 
Published: May 2019

AbstractCoral skeletons are the most commonly used high‐resolution temperature proxy in the tropical oceans, providing paleoclimate reconstructions dating back centuries to millennia. However, physiological differences in skeletal formation modes together with artifacts arising from coral biomineralization (vital effects) can confound the temperature dependence of single element‐to‐calcium ratios. In efforts to reduce vital effects and isolate temperature, new approaches have been developed based on Sr‐U and Li/Mg, which combine Sr/Ca and U/Ca and Li/Ca and Mg/Ca, respectively. Here we examine the systematics of Sr/Ca, Sr‐U, and Li/Mg paleothermometry in 33 colonies of branching (Acropora, Pocillopora, and Stylophora) and foliose (Turbinaria) genera. To address the calibration of these morphologically complex calcifiers, we conducted repeat field trips every 1 to 3 months and collected the most recent (~1 month) uppermost growth of individual colonies over ~18‐ to 24‐month periods. This enables seasonally resolved calibration of genera that exhibit rapid extension and slower secondary calcification. Based on this experimental design, we show that all three proxies capture seasonal to annual temperature variations for their respective growth intervals, providing calibrations across an 11 °C range. Species effects on the temperature dependence were largest for Sr/Ca (22.7%) yet minor for Li/Mg (7.2%) and Sr‐U (6.3%). Residuals from proxy‐temperature regressions were correlated between Sr/Ca and Li/Mg, indicating similar biological processes may influence Sr/Ca and Li/Mg thermometry. The implications of this study are that Sr‐U and to a lesser extent Li/Mg are applicable to fossil branching coral skeletons identified to genus level without the need for modern‐day calibration. We further show that all three paleothermometers provide complementary temperature constraints, with Li/Mg and the more species‐dependent Sr/Ca showing greater effectiveness at resolving seasonal variability and Sr‐U showing greater reliability at capturing mean annual temperature.
Crustal Fault Connectivity of the Mw 7.8 2016 Kaikōura Earthquake Constrained by Aftershock Relocations
Authors: Lanza F. , Chamberlain C. J. , Jacobs K. , Warren‐Smith E. , Godfrey H. J. , Kortink M. , Thurber C. H. , Savage M. K. , Townend J. , Roecker S. , Eberhart‐Phillips D. 
Published: May 2019

AbstractThe 14 November 2016 Mw7.8 Kaikōura earthquake in the northern South Island, New Zealand, involved highly complex, multifault rupture. We combine data from a temporary network and the permanent national seismograph network to repick and relocate ~2,700 aftershocks of M≥3 that occurred between 14 November 2016 and 13 May 2017. Automatic phase‐picking is carried out using REST, a newly developed hybrid method whose pick quality is assessed by comparing automatic picks for a subset of 138 events with analysts' picks. Aftershock hypocenters computed from high‐quality REST picks and a 3‐D velocity model cluster almost exclusively in the shallow crust of the upper plate and reveal linkages at depth between surface‐rupturing fault segments. Only eight aftershocks are relocated on a deeper structure positioned between patches of geodetically detected afterslip. This indicates that afterslip has not triggered significant earthquake activity on the subduction interface during the period of aftershock activity analyzed.
E4orf1 protein reduces the need for endogenous insulin
Authors: Peddibhotla Swetha , Hegde Vijay , Akheruzzaman Md , Dhurandhar Nikhil V. 
Published: May 2019

Abstract
Background
E4orf1 protein derived from adenovirus-36 reduces glucose excursion in mice, and lowers endogenous insulin response, suggesting a reduced need for insulin. We tested if the E4orf1-mediated lowering of insulin response is due to increased tissue sensitivity to insulin, reduced ability to produce or release insulin, or a reduced need for insulin release.

Methods
Experiment 1: hyperinsulinemic–euglycemic clamps (HEC) and glucose tolerance test (GTT) were performed in high fat fed transgenic mice expressing E4orf1 or non-transgenic littermates (n = 12 each), for 4 weeks. Experiments 2, 3, and 4: E4orf1 or null vectors were expressed in rat-pancreatic β-cell line (INS-1) for 72 h, and cells were exposed to varying levels of glucose. Cell lysates and media were collected. Experiment 5: 3T3L1-preadipocytes that express E4orf1 upon doxycycline induction, or null vector were induced with doxycycline and then exposed to protein transport inhibitor. Supernatant and cell lysate were collected. Experiment 6: 3T3L1-preadipocytes that express E4orf1 upon doxycycline induction, or null vector were co-cultured with INS-1 cells for 24 h. Media was collected.

Results
Experiment 1: E4orf1 transgenic mice cleared glucose faster compared to non-transgenic mice during GTT. HEC showed that E4orf1 did not alter tissue sensitivity to exogenous insulin in mice. Experiments 2, 3, and 4: in INS1 cells, E4orf1 did not alter Glut2 abundance or Akt activation, suggesting no reduction in glucose sensing or insulin synthesis, respectively. E4orf1 did not influence glucose-stimulated insulin secretion in media by INS1 cells. Experiment 5: E4orf1 was present in cell lysate, but not in media, indicating it is not a secretory protein. Experiment 6: INS1 cells released less insulin in media when co-cultured in the presence of E4orf1-expressing 3T3-L1 cells.

Conclusions
Our studies support the working hypothesis that the E4orf1-mediated lowering of insulin response is not due to increased tissue sensitivity to insulin, or reduced ability to produce or release insulin, but likely to be due to a reduced need for insulin release.
RETRACTED ARTICLE: Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer
Authors: Yu Hong-En , Wang Feng , Yu Fang , Zeng Zhao-Lei , Wang Yun , Lu Yun-Xin , Jin Ying , Wang De-Shen , Qiu Miao-Zhen , Pu Heng-Ying , Kang Tie-Bang , Xie Dan , Ju Huai-Qiang , Xu Rui-Hua , Luo Hui-Yan 
Published: May 2019

AbstractGastric cancer (GC) is one of the most common malignancies worldwide. Due to the low rate of early detection, most GC patients were diagnosed as advance stages and had poor response to chemotherapy. Some studies found that Fumarate hydratase (FH) participated in the DNA damage response and its deficiency was associated with tumorigenesis in some cancers. In this study, we investigated the relationship between FH and cisplatin (CDDP) sensitivity in GC cell lines. We found that FH was the most significant gene which induced by CDDP treatment and the suppression of FH could enhance the cytotoxicity of CDDP. Miconazole Nitrate (MN) could inhibit FH activity and enhance the effect of CDDP in vitro and in vivo. We also investigated the significance of expression of FH in GC tissues. The FH expression, which was higher in GC tissues than in noncancerous tissues, was negatively associated with the prognosis of patients. Together, these results revealed that FH is a reliable indicator for response to CDDP treatment in GC and the inhibition of FH may be a potential strategy to improve the effects of CDDP-based chemotherapy.
A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer
Authors: Mazzoldi Elena Laura , Pavan Simona , Pilotto Giorgia , Leone Kevin , Pagotto Anna , Frezzini Simona , Nicoletto Maria Ornella , Amadori Alberto , Pastò Anna 
Published: May 2019

AbstractReceptors tyrosine kinase (RTK) enable normal and tumor cells to perceive and adapt to stimuli present in the microenvironment. These stimuli, also known as growth factors, are important molecular cues actively supporting cancer stem cell (CSC) self-renewal and viability. Since in epithelial ovarian cancer (EOC) the expression of c-Kit (CD117) has been identified as a CSC hallmark, we investigated the existence of a tumor growth-promoting loop between c-Kit and its ligand Stem Cell Factor (SCF). SCF exists as a soluble or transmembrane protein and through c-Kit interaction regulates cell viability, proliferation, and differentiation both in physiological and pathological conditions. High amounts of SCF were found in the ascitic effusions collected from EOC patients. While tumor cells and CSC only expressed the membrane-associated SCF isoform, both secreted and membrane-bound isoforms were expressed by tumor-associated macrophages (TAM, here shown to be M2-like) and fibroblasts (TAF). Circulating monocytes from EOC-bearing patients and healthy donors did not express both SCF isoforms. However, monocytes isolated from healthy donors produced SCF upon in vitro differentiation into macrophages, irrespectively of M1 or M2 polarization. In vitro, both SCF isoforms were able to activate the Akt pathway in c-Kit+cells, and this effect was counteracted by the tyrosine kinase inhibitor imatinib. In addition, our results indicated that SCF could help c-Kit+CSC survival in selective culture conditions and promote their canonical stemness properties, thus indicating the possible existence of a juxtacrine/paracrine circuit in EOC.
Tuning porosity in macroscopic monolithic metal-organic frameworks for exceptional natural gas storage
Authors: Connolly B. M. , Aragones-Anglada M. , Gandara-Loe J. , Danaf N. A. , Lamb D. C. , Mehta J. P. , Vulpe D. , Wuttke S. , Silvestre-Albero J. , Moghadam P. Z. , Wheatley A. E. H. , Fairen-Jimenez D. 
Published: May 2019

AbstractWidespread access to greener energy is required in order to mitigate the effects of climate change. A significant barrier to cleaner natural gas usage lies in the safety/efficiency limitations of storage technology. Despite highly porous metal-organic frameworks (MOFs) demonstrating record-breaking gas-storage capacities, their conventionally powdered morphology renders them non-viable. Traditional powder shaping utilising high pressure or chemical binders collapses porosity or creates low-density structures with reduced volumetric adsorption capacity. Here, we report the engineering of one of the most stable MOFs, Zr-UiO-66, without applying pressure or binders. The process yields centimetre-sized monoliths, displaying high microporosity and bulk density. We report the inclusion of variable, narrow mesopore volumes to the monoliths’ macrostructure and use this to optimise the pore-size distribution for gas uptake. The optimised mixed meso/microporous monoliths demonstrate Type II adsorption isotherms to achieve benchmark volumetric working capacities for methane and carbon dioxide. This represents a critical advance in the design of air-stable, conformed MOFs for commercial gas storage.
Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells
Authors: Rosenbaum Marc , Gewies Andreas , Pechloff Konstanze , Heuser Christoph , Engleitner Thomas , Gehring Torben , Hartjes Lara , Krebs Sabrina , Krappmann Daniel , Kriegsmann Mark , Weichert Wilko , Rad Roland , Kurts Christian , Ruland Jürgen 
Published: May 2019

AbstractRegulatory T cells (Tregs) have crucial functions in the inhibition of immune responses. Their development and suppressive functions are controlled by the T cell receptor (TCR), but the TCR signaling mechanisms that mediate these effects remain ill-defined. Here we show that CARD11-BCL10-MALT1 (CBM) signaling mediates TCR-induced NF-κB activation in Tregs and controls the conversion of resting Tregs to effector Tregs under homeostatic conditions. However, in inflammatory milieus, cytokines can bypass the CBM requirement for this differentiation step. By contrast, CBM signaling, in a MALT1 protease-dependent manner, is essential for mediating the suppressive function of Tregs. In malignant melanoma models, acute genetic blockade of BCL10 signaling selectively in Tregs or pharmacological MALT1 inhibition enhances anti-tumor immune responses. Together, our data uncover a segregation of Treg differentiation and suppressive function at the CBM complex level, and provide a rationale to explore MALT1 inhibitors for cancer immunotherapy.
Microring resonator-assisted Fourier transform spectrometer with enhanced resolution and large bandwidth in single chip solution
Authors: Zheng S. N. , Zou J. , Cai H. , Song J. F. , Chin L. K. , Liu P. Y. , Lin Z. P. , Kwong D. L. , Liu A. Q. 
Published: May 2019

AbstractSingle chip integrated spectrometers are critical to bring chemical and biological sensing, spectroscopy, and spectral imaging into robust, compact and cost-effective devices. Existing on-chip spectrometer approaches fail to realize both high resolution and broad band. Here we demonstrate a microring resonator-assisted Fourier-transform (RAFT) spectrometer, which is realized using a tunable Mach-Zehnder interferometer (MZI) cascaded with a tunable microring resonator (MRR) to enhance the resolution, integrated with a photodetector onto a single chip. The MRR boosts the resolution to 0.47 nm, far beyond the Rayleigh criterion of the tunable MZI-based Fourier-transform spectrometer. A single channel achieves large bandwidth of ~ 90 nm with low power consumption (35 mW for MRR and 1.8 W for MZI) at the expense of degraded signal-to-noise ratio due to time-multiplexing. Integrating a RAFT element array is envisaged to dramatically extend the bandwidth for spectral analytical applications such as chemical and biological sensing, spectroscopy, image spectrometry, etc.
Boosting BCG with proteins or rAd5 does not enhance protection against tuberculosis in rhesus macaques
Authors: Darrah Patricia A. , DiFazio Robert M. , Maiello Pauline , Gideon Hannah P. , Myers Amy J. , Rodgers Mark A. , Hackney Joshua A. , Lindenstrom Thomas , Evans Thomas , Scanga Charles A. , Prikhodko Victor , Andersen Peter , Lin Philana Ling , Laddy Dominick , Roederer Mario , Seder Robert A. , Flynn JoAnne L. 
Published: May 2019

AbstractTuberculosis (TB) is the leading cause of death from infection worldwide. The only approved vaccine, BCG, has variable protective efficacy against pulmonary TB, the transmissible form of the disease. Therefore, improving this efficacy is an urgent priority. This study assessed whether heterologous prime-boost vaccine regimens in which BCG priming is boosted with either (i) protein and adjuvant (M72 plus AS01E or H56 plus CAF01) delivered intramuscularly (IM), or (ii) replication-defective recombinant adenovirus serotype 5 (Ad5) expressing various Mycobacterium tuberculosis (Mtb) antigens (Ad5(TB): M72, ESAT-6/Ag85b, or ESAT-6/Rv1733/Rv2626/RpfD) administered simultaneously by IM and aerosol (AE) routes, could enhance blood- and lung-localized T-cell immunity and improve protection in a nonhuman primate (NHP) model of TB infection. Ad5(TB) vaccines administered by AE/IM routes following BCG priming elicited ~10–30% antigen-specific CD4 and CD8 T-cell multifunctional cytokine responses in bronchoalveolar lavage (BAL) but did not provide additional protection compared to BCG alone. Moreover, AE administration of an Ad5(empty) control vector after BCG priming appeared to diminish protection induced by BCG. Boosting BCG by IM immunization of M72/AS01E or H56:CAF01 elicited ~0.1–0.3% antigen-specific CD4 cytokine responses in blood with only a transient increase of ~0.5–1% in BAL; these vaccine regimens also failed to enhance BCG-induced protection. Taken together, this study shows that boosting BCG with protein/adjuvant or Ad-based vaccines using these antigens, by IM or IM/AE routes, respectively, do not enhance protection against primary infection compared with BCG alone, in the highly susceptible rhesus macaque model of tuberculosis.