bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated tumor mutation burden in patients with cancer with underlying HIV infection: data from the Oncology Research Information Exchange Network (ORIEN)
Authors: Coghill Anna E. , Van Bibber Nathan , Baiocchi Robert A. , Arnold Susanne M. , Riedlinger Gregory , Schneider Bryan P. , Zhang Yonghong , Suneja Gita , Gomez Fontela Miguel , Abate-Daga Daniel , Teer Jamie K. 
Published: February 2025

Abstract
Background: People living with HIV (PWH) have improved life expectancy due to effective HIV therapy but still experience immune impairment (e.g., altered CD4/CD8 T-cells). We hypothesized that tumors diagnosed in PWH would have distinct molecular features. Methods: We utilized whole exome sequencing of paired tumor and germline DNA and RNA sequencing of tumors from 229 patients with cancer enrolled into ORIEN to classify: total tumor mutation burden (TMB), major histocompatibility complex (MHC) class I neoantigen count, and MHC class II neoantigen count. Results: Specimens from 229 patients with cancer (110 PWH and 119 without HIV) were evaluated. Average TMB for tumors diagnosed in PWH was 249, compared to 172 for those without HIV. After adjustment for age, sex, race, smoking, and cancer site, the association between HIV and TMB remained statistically significant (OR=1.72; 95% CI: 1.26-2.43). We further observed an association between HIV and higher class I neoantigen count (OR=1.62; 95% CI: 1.10-2.41) but no association with putative class II neoantigens. When considering cancer sites separately in unadjusted analyses, average TMB was elevated in PWH for thyroid (p&lt;0.01) and bladder cancers (p=0.03), and sarcoma (p=0.04). Similarly, putative class I neoantigen count was elevated in PWH for head & neck (p&lt;0.01) and thyroid (p=0.01) cancers, and sarcoma (p=0.04). Conclusion: Our findings indicate that tumors diagnosed in PWH harbor a higher TMB and a higher number of putative class I neoantigens. Impact. A higher TMB in PWH may portend a more favorable response to cancer treatment modalities such as immune checkpoint inhibitors.
Greater adherence to lifestyle recommendations after cancer diagnosis is associated with lower mortality in the UK Biobank
Authors: Byrne Stephanie , Hypponen Elina , Benyamin Beben , Boyle Terry 
Published: February 2025

Abstract
Background: Research supporting the current recommendation to adhere to a healthy lifestyle following cancer diagnosis is limited. We investigated whether a healthy lifestyle after diagnosis is associated with a lower risk of mortality among those diagnosed with any malignant cancer, and breast, colorectal and prostate cancers. Methods: In 2006-2010, UK Biobank participants (aged 37-73 years) were assessed. Analyses were restricted to those with a malignant cancer diagnosis prior to baseline (n=20,805, including 5,845 breast, 1,943 colorectal and 2,715 prostate cancer cases). Participants were followed for all-cause and cancer-specific death up to November 2022. A lifestyle index was determined based on lifestyle recommendations for cancer prevention. Cox regression was used to examine associations with all-cause and cancer-specific mortality among those with any cancer, and separately for breast, colorectal and prostate cancers, adjusting for relevant confounders. Results: There were 4,328 deaths and 3,354 cancer-specific deaths in the 258,985 person-years of follow up. A higher lifestyle index, representing greater adherence to recommendations, was associated with a lower risk of all-cause mortality (any cancer - highest vs lowest lifestyle index tertile: HR[95%CI]=0.77[0.71,0.83]; breast: 0.75[0.64,0.88]; colorectal: 0.68[0.52,0.89]; prostate: 0.73[0.59,0.89]), and cancer-specific mortality in all populations examined (any cancer: 0.82[0.75,0.89]; breast: 0.88[0.71,1.09]; colorectal: 0.58[0.36,0.94]; prostate: 0.70[0.53,0.93]), although evidence was weaker for cancer-specific mortality among colorectal and breast cancer survivors. Conclusions: Our findings provide evidence to support the recommendation to follow a healthy lifestyle after cancer diagnosis to prolong life. Impact: Clinical guidelines and public health programs promoting a healthy lifestyle to cancer survivors may prolong life.
Induction of Triple Negative Breast Cancer Cell Death and Chemosensitivity using mTORC2-directed RNAi Nanomedicine
Authors: Patel Shrusti S. , Cook Rebecca S. , Lo Justin H. , Cherry Fiona K. , Hoogenboezem Ella N. , Yu Fang , Francini Nora , Cassidy Nina T. , McCune Joshua T. , Gbur Eva F. , Messier Lisa , Dean Thomas A. , Wilson Kalin L. , Brantley-Sieders Dana M. , Duvall Craig L. 
Published: February 2025

Abstract
Alterations in the phosphatidylinositol 3-kinase (PI3K) signaling / mammalian target of rapamycin (mTOR) signaling pathway are often seen in triple negative breast cancers (TNBCs), a breast cancer subtype characterized by limited molecularly targeted treatment options and poorer patient outcomes. We report that gene amplification or overexpression of the mTORC2-required cofactor RICTOR correlated with increased mTORC2 signaling and worse patient outcome in clinical BC expression datasets, supporting studies examining selective mTORC2 inhibition in TNBC. The mTOR kinase inhibitor PP242 blocks both mTORC1 and mTORC2, which decreases growth and survival of RICTOR-amplified TNBC cells. However, mTORC1 inhibition by PP242 causes resurgent PI3K kinase signaling, limiting its therapeutic impact. In contrast, knockdown using short interfering RNA (siRNA) designed against Rictor (siRictor) did not increase PI3K or mTORC1 signaling, but potently blocked mTORC2 signaling, resulting in robust inhibition of tumor cell growth and survival. We developed siRictor-loaded nanoparticles to enable therapeutic testing of Rictor silencing in TNBCs in vivo. Intravenous delivery of this mTORC2-selective nanomedicine achieved siRNA accumulation and on-target gene silencing in TNBC tumors in vivo. Rictor silencing blocked tumor mTORC2 signaling and growth in multiple TNBC mouse models while also improving TNBC tumor response to chemotherapy. These findings support the further development of technologies for therapeutic Rictor silencing as an effective approach for mTORC2-selective inhibition and treatment in TNBC.
“Profane Like Esau”
Authors: Easter Matthew C. 
Published: February 2025

Abstract
The author of Hebrews accuses Esau of sexual immorality in Heb 12:16. This essay argues Esau’s sexual immorality is his marriage to foreign women, which sowed seeds of discord in the family and led ultimately to his unredeemable exclusion from the community. Esau’s exogamous marriage, as such, is not the concern in Hebrews, but rather how his mixed marriage introduced bitterness into the family and led ultimately to him abandoning the group. Like the wilderness generation in Num 13–14, Esau lost his inheritance by failing to persevere with the community. Tested against recent studies of conversion and deconversion, we see how Esau becomes a paradigmatic community-abandoning apostate and a warning against similar abandonment.
Who Are “We” in Romans?
Authors: Thorsteinsson Runar M. 
Published: February 2025

Abstract
Pauline scholarship has often struggled with the question of who is included when Paul uses the first-person plural, “we,” in Romans, but so far an overall analysis of this language in Paul’s letter has been lacking. This article provides a general overview of the first-person plural in Romans, proposes a methodological approach to the problem, and applies that approach in order to solve several intricate and controversial cases, including ἐλάβομεν in 1:5, προεχόμεθα in 3:9a, and the notable crux interpretum, προῃτιασάμεθα in 3:9b. It is argued that “we” in Romans can be classified into three basic categories in this respect: (1) “we” including Paul and his addressees and/or Jesus believers in general, (2) “we” including Paul and his co-workers, and (3) “we” including the diatribal addressees (not including Paul himself). While the last category applies to προεχόμεθα, both ἐλάβομεν and προῃτιασάμεθα include Paul and his co-workers (category 2).
Shifting Attitudes toward the “Saucer” Question in Mid-Century American Pentecostalism
Authors: Crace Benjamin D. 
Published: February 2025

Abstract
After some basic background and outlining of key contextual elements, this article examines the commentaries of William Branham, O.L. Jaggers, Gordon Lindsay, and Frank Stranges on the rise and growing popularity of the UFO phenomenon through the 1950s and 1960s. This brief survey tracks the shift from pluralistic interpretations to the dominant demonic interpretation while highlighting the accompanying nationalistic and apocalyptic milieu. It concludes with a brief deconstruction to clear the ground for future potential research.
Swedish Pentecostal Churches’ Use of the Concept of Mission
Authors: Kuhlin Julia 
Published: February 2025

Abstract
Over the past two decades, the Swedish pentecostal movement has undergone a major transformation in its way of organizing and collaborating around mission work. In this explorative study, the purpose is to investigate how these and other changes have influenced how contemporary Swedish pentecostal churches understand and make use of the concept of mission. The data for the study consists of texts from the churches’ websites and draws on conceptual history in its theoretical and methodological approach. The findings of the study indicate a theological shift within the Swedish pentecostal movement. Among other things, it highlights a disconnect between the concept of mission and eschatological urgency and notes that priority is no longer given to mission as evangelism, over social work. The study also points to a linguistic instability associated with the concept of mission wherein the term “international work” is being used interchangeably with it and has, on some churches’ websites, even replaced the “mission” altogether, a finding that suggests an ongoing dispute over the definition of mission.
The Imago Dei and the Indwelling Spirit
Authors: Warren E. Janet 
Published: February 2025

Abstract
Charismatic theology has engaged little with the concept of the imago Dei and has sometimes emphasized eschatology over creation. This article reconsiders views on the imago Dei in light of the concept of divine presence, building on notions of intensification and suggesting the concept of activation. I propose that as God breathes his Spirit into the first humans and pours out his Spirit on all flesh, a primary way in which we image God is by manifesting his divine presence in the world. Through the indwelling Spirit (a structural aspect of the imago Dei that is activated through belief in Christ), we are united with God the Father and one another (relational aspects of the imago Dei) and enabled to exercise responsible dominion over creation (a functional aspect). Thus the Spirit at creation is continuous with the Spirit at Pentecost.
Animal Glossolalia
Authors: Rizzo Daniela 
Published: February 2025

Abstract
This article extends the concept of glossolalia to encompass the idea of creaturely “sighs and groans,” emphasizing that animals, despite the apparent absence of reflective consciousness, harbor the capacity for expressions such as praise, lament, and prophecy. Within this research, a model of “animal glossolalia” is introduced, transcending the confines of human experience to delve into how animals engage in this unique form of spiritual expression through the Spirit. It posits that God hears the voices of all his non-human creatures through their sighs and groans. This exploration of animal spirituality and glossolalia challenges prevailing anthropocentric perspectives, advocating for a broader and more inclusive comprehension of glossolalia that embraces all of God’s creatures through the interceding Spirit.
A Holy Human Spirit
Authors: Griffiths John D. 
Published: February 2025

Abstract
Luke’s use of πνεῦμα ἅγιον stands out from the other phrases that he utilises in Luke-Acts, due to its anarthrous form. While most scholars understand the anarthrous phrase πνεῦμα ἅγιον as a one-of-a-kind expression, the presence of other πνεῦμα, both divine and human, in Luke-Acts indicates that the anarthrous phrase πνεῦμα ἅγιον might refer to something other than the Holy Spirit. In this article, I posit that the anarthrous phrase πνεῦμα ἅγιον refers to a holy human spirit in Luke 4:1 and Acts 2:4. That is, πνεῦμα ἅγιον describes the resultant state of the human spirit after the Holy Spirit has come upon a person.
Russia on Our Mind
Authors: Davidsson Tommy H. 
Published: February 2025

Abstract
Russia has had a bad reputation in the West for most of the twentieth and twenty-first centuries. Russia’s unprovoked attack on Ukraine in February 2022 reversed any lingering optimism that followed in the wake of Mikhail Gorbachev’s perestroika and glasnost reform programs at the end of the 1980s. Western Pentecostals not only have shared this negative view of Russia but also have viewed Russia in a negative eschatological light. This article aims to show, however, that Western Pentecostal perceptions have not always been negative, at least in early Pentecostalism. By a historical analysis of Western Pentecostal periodicals from the last years of the Russian Empire (1910–1917), through the Russian Civil War (1917–1922), to the initial years of the Soviet Union (1922–1929), the article demonstrates that perceptions of early Western Pentecostals fluctuated quite significantly in this period and were due to a changing historical situation and the efforts of influential leaders like William Fetler. The article concludes with an analysis of the reasons for the shifting perceptions.
What Would an Ancient Person Think of Tongues of Fire?
Authors: Glover Daniel 
Published: February 2025

Abstract
This article seeks to answer the question, What would an ancient person have thought of the tongues of fire in Acts 2:1–4? In seeking to answer this question, it contextualizes both Luke’s earliest readers and their probable interpretation within ancient Mediterranean literary culture. The article argues that the framework most readily available to such readers would have been epiphany narratives. After demonstrating the validity of this reading, the article turns to the literary purpose for epiphany and argues that Acts 2:1–4 shares that same purpose: to justify the introduction of a new god (Jesus), his worship, and his community of followers. The article concludes with implications for Luke’s literary procedure and role in defining and norming early “Christianity.”
Translation as Social and Ecological Justice
Authors: Yong Amos 
Published: February 2025

Abstract
This review essay focuses on a variant of Roman Jakobson’s interlingual typology of translation. It suggests that we reevaluate our interpretation of natural signs to secure a broader ontological and cosmological platform from which to theologize about the interlingual forms of communicative interpretation. Pamela Beattie, Simona Bertacco, and Tatjana Soldat-Jaffe’s Time, Space, Matter in Translation; Maria Dasca and Rosa Cerarols’ Translation Studies and Ecology; and Wine Tesseur’s Translation as Social Justice provide a ramp in precisely this direction.
Forced Migrants In Europe and Their Cultural Rights: In Need of Minority Protection
Authors: Xanthaki Alexandra 
Published: February 2025

Abstract
Discussions and efforts to improve the rights of forced migrants in Europe are ongoing as the situation continues to be dire. All such discussions and policies though have completely neglected so far the protection that the human rights system recognises to members of minorities. This article argues that forced migrants are entitled to such minority protection. It further argues that their recognition, as beneficiaries of such protection will address more comprehensively their needs and strengthen their rights. The article focuses on the cultural rights of forced migrants, as important rights connected to their identity. It demonstrates the gaps in the international law machinery used at the moment as well as the added value that the minority protection would have on their rights. Using such protection for migrants’ rights is consistent with international law, will strengthen their protection but also will be beneficial to the minority rights protection too.
Mapping the Field
Authors: Hofmann Rainer , Malkmus Moritz 
Published: February 2025

Abstract
International law does not provide for a universally accepted definition of the notion of ‘minorities’. This situation has prompted large numbers of states, especially in the European context, to adopt rather restrictive approaches, making any recognition of a minority status conditional on criteria such as citizenship or a temporal link to a particular territory. In contrast thereto, there has been a clear tendency in the ever growing corpus of opinions of international expert (treaty) bodies that free self identification, rather than the restrictive criteria mentioned above, should be the decisive criterion for assessing minority membership. The purpose of this paper is to evaluate these developments.
Decolonising Minority Rights Discourse
Authors: Shahabuddin Mohammad 
Published: February 2025

Abstract
Mainstream discourse on minority rights embodies a series of normative biases and assumptions, which ignore the colonial underpinning of some of the core concepts such as the definition of minority and the notion of minority protection. In this paper, I argue that contemporary minority rights discourse needs to engage closely with relations of power and subaltern agency to ‘decolonise’ conventional thinking within the discipline. I unpack this decolonising agenda and map out what such an agenda would entail by critically analysing five key areas of relevance: reconceptualising the minority to expose ‘otherness’ embedded in the concept; scrutinising the reification of the state as a prerequisite for decolonising minority rights discourse; mainstreaming subaltern resistance; reevaluating a priori assumptions about the need for legal interventions; and finally, taking seriously the political economy of neo-colonial violence. Thus, the paper offers a framework for systematically thinking about decolonial promises of minority rights discourse.
Atmospheric Water Resources and Their Exploitability in the Middle East
Authors: Li Fang-Fang , Lu Hou-Liang , Wang Hong-Ru , Sun Peng , Qiu Jun 
Published: February 2025

Abstract
The Middle East (ME) has suffered from severe water stress owing to the limited availability of surface freshwater. The exploitation of atmospheric water may be a potential solution for resolving the water crisis in the ME. This study presents a comprehensive analysis of atmospheric water resources, as well as their exploitability, mainly including the evaluation of precipitation and atmospheric water resources, imbalance analysis between precipitation and atmospheric water, and trend analysis. The exploitability of air water resources was also studied in combination with the vertical distribution of air water vapor. The results indicate that the precipitable water in most areas of the ME shows a significant increasing trend, but the Arabian Peninsula is becoming drier due to the decline in the ability to convert atmospheric water resources to precipitation; the most recommended areas for artificial precipitation exist in southern Sudan and Chad and western Turkey, which have rich background water vapor and preferred precipitation conversion mechanisms. Such knowledge provides a reference for the exploitation of atmospheric water resources in the ME.
EARLY CHILDHOOD DEVELOPMENT AS A PREDICTOR OF BETTER HEALTH OUTCOMES IN LATER LIFE
Authors: Paszthy Bea 
Published: February 2025

Despite remarkable progress in health status and life expectancy in the developed countries over the past decades, large inequalities remain not only across countries but also across population groups in each country. These inequalities in health status are linked to many factors, including differences in exposure to risk factors to health and in access to health care. Inequalities in health status are due to many factors, including differences in living and working conditions and in behavioral factors. Lifestyle behaviors ( eg. nutrition habits, physical inactivity, obesity, smoking and alcohol drinking) are important risk factors for many diseases including diabetes, cardiovascular diseases and cancers and vastly affect oral health as well. People in lower socioeconomic groups are more likely to smoke, be obese and be exposed to other important behavioral risk factors. Efforts targeting behavioral risk factors among disadvantaged groups can play an important role in promoting healthier lifestyles, offering individuals better choices, and reducing health inequalities. A key focus should be early child development. Good early development is a predictor of better health outcomes in later life. During pregnancy and the first few weeks and months of life, critical stages in the child’s mental and physical development follow each other in rapid succession. Each stage serves as a foundation for the next. Any faltering in early childhood therefore puts at risk subsequent stages of growth and development. There is an increasing number of mental health problems. One in five children and adolescents experience psychological conditions and/or psychiatric disorders. People with mental illness have increased risk of dental diseases due to several factors: fear, habits, life-style choices, cost, distrust of dentists, negative past experiences or stigma felt at a dentist visit, lack of knowledge about oral hygiene, lack of awareness of their own oral health problems, side effects of certain medications. However many people living with mental illness, dental health may be a low priority. Oral symptoms may be the first or only manifestation of a mental health problem.
SOCIAL GRADIENT IN CARIES EXPERIENCE AND ORAL HYGIENE BEHAVIOURS IN THE BELGIAN POPULATION
Authors: De Reu G. , Lambert M. , Declerck D. , Bottenberg P. , Vanobbergen J. 
Published: February 2025

Methods: The data are derived from the Belgian “Oral Health Data Registration and Evaluation System (OHDRES) 2009”, collected between September 2009 and November 2010. A multi-stage, stratified cluster sampling technique was used to obtain a sample representative of the Belgian population aged 5 years and older. Data collection consisted of an Oral Health Interview (self-administered questionnaire, pre- tested and validated) and a standardized Oral Health Examination by a dentist during a home visit. ANOVA and multivariable regression analyses were used to reveal associations between social parameters and oral hygiene related parameters with oral health outcomes after correction for age and sex. School aged children, students and retired people were excluded for inferential analyses. Results: 2742 subjects completed the questionnaire, a clinical oral examination was done for 2563 participants. 53% (N= 1,495) of the participants were female, mean age of 43 years. From the total population 11.1 % were caries-free. The mean DMFT was 10.8 (±8.71). Employment status had a significant influence on untreated tooth decay (p=0.05) and edentulism (p=0.02) while untreated tooth decay was also influenced by frequency of tooth brushing and plaque index (p<0.002 and p>0.001 respectively). People having higher education versus lower or no education or having Belgian nationality versus non-Belgian nationality have lower DMFT-scores (both p=0.003). Conclusions: Caries prevalence, expressed as mean DMFT and proportion of untreated tooth decay in Belgium are influenced by level of education and employment status respectively. Underprivileged groups have higher DMFT and more untreated dental decay.