bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluconazole treatment in severe ectopic Cushing syndrome
Authors: Canteros Teresa M , De Miguel Valeria , Fainstein-Day Patricia 
Published: July 2019

Summary
Severe Cushing syndrome (SCS) is considered an emergency that requires immediate treatment to lower serum cortisol levels. Fluconazole may be considered an alternative treatment in Cushing syndrome when ketoconazole is not tolerated or unavailable. We report a 39-year-old woman with a history of partial pancreaticoduodenectomy due to a periampullary neuroendocrine tumor with locoregional extension. Three years after surgery, she developed liver metastases and was started on 120 mg of lanreotide/month, despite which, liver metastases progressed in the following 6 months. The patient showed extreme fatigue, muscle weakness, delirium, moon face, hirsutism and severe proximal weakness. Laboratory tests showed anemia, hyperglycemia and severe hypokalemia. 24-h urinary free cortisol: 2152 nmol/day (reference range (RR): <276), morning serum cortisol 4883.4 nmol/L (RR: 138–690), ACTH 127.3 pmol/L (RR: 2.2–10). She was diagnosed with ectopic ACTH syndrome (EAS). On admission, she presented with acute upper gastrointestinal tract bleeding and hemodynamic instability. Intravenous fluconazole 400 mg/day was started. After 48 h, her mental state improved and morning cortisol decreased by 25%. The dose was titrated to 600 mg/day which resulted in a 55% decrease in cortisol levels in 1 week, but then had to be decreased to 400 mg/day because transaminase levels increased over 3 times the upper normal level. After 18 days of treatment, hemodynamic stability, lower cortisol levels and better overall clinical status enabled successful bilateral adrenalectomy. This case report shows that intravenous fluconazole effectively decreased cortisol levels in SCS due to EAS.

Learning points:

Severe Cushing syndrome can be effectively treated with fluconazole to achieve a significant improvement of hypercortisolism prior to bilateral adrenalectomy.

Intravenous fluconazole is an alternative treatment when ketoconazole is not tolerated and etomidate is not available.

Fluconazole is well tolerated with mild side effects. Hepatotoxicity is usually mild and resolves after drug discontinuation.
Prof. Vladas Jurgutis on banks: his insights and their development in works Lithuanian author‘s
Authors: Mackevičius Jonas , Savickas Vilius 
Published: July 2019

The article analyses prof. V. Jurgutis‘ thoughts, attitudes, ideas and suggestions towards the importance of banks, their management, competition among them, etc. The article presents the development of V. Jurgutis’ insights into bank performance in works of Lithuanian authors.
The study reveals that V. Jurgutis’ insights into banks’ performance is inestimable for Lithuanian banking science and practice professionals. Especially valuable are his thoughts and ideas towards the organization and rationalization of banks, their employee structure and relations, the competition and the expansion of banks. Statements formulated in prof. V. Jurgutis work "Banks" have encouraging influences on the growth of the effectiveness of bank performance, and are relevant to both the regulation of bank performance in Lithuania and the transition to Euro.
Therefore, with the consideration of today's realities, it is necessary to further analyse V. Jurgutis‘ scientific heritage and implement his ideas into practice.
Analysis of the accounting speciality collage graduates’ employment opportunities at the labour market in the context of the workforce supply and demand
Authors: Bagdonienė Audronė , Smolenskienė Fausta 
Published: July 2019

The problems which young people face with in order to get employed and survive, to compete successfully in the labour market has always been relevant to the society. It is obvious that after the completion of the training institutions the graduates can hope to get employed if their specialty is in high demand in the labour market. Permanent labour market demand and supply indicators are monitored and analysis allows to foresee the changes of the tendencies and trends to find out which specialty is needed most and have the most job opportunities in the world of work. Therefore, the research problem is revealed by the following questions: What are the opportunities to get employed having accounting profession? Are the people, gained such education, in demand in the labour market?
The aim of the investigation – to evaluate the accounting specialty graduates’ employment opportunities in the labour market.
Youth situation in the labour market is not favourable, and still significant positive changes still are not visible, because in recent years in recent years there at the labour centre applied approximately 70 thousand young people under 25 and about 20 thousand graduates. However, an analysis of the need for accounting professionals and graduates who have acquired the specialty of integration into the labour market statistics show that the demand for these professionals is not decreasing. As pointed out by some labour market analysts, this is one of the most stable professions and such individuals have significant employment opportunities in this field. This is also confirmed by the results of analysis: every year, employers offer about 2-3 thousand jobs for accountants and book-keepers; there are favourable employment opportunities in all regions of the country, as more and more businessmen are choosing financial services companies receive all levels of accounting services; every year graduates, who have acquired the specialty, number is decreasing, so the competition is to prepare professionals in the labour market is weakening; vacancy rate remains stable (on average by 0.6 per cent.), excess supply in the market for these professionals is not high, i.e. 2 persons apply for 1 vacancy.
The effectiveness of ABC method in small companies
Authors: Klimaitienė Rūta , Rudžionienė Kristina , Verbliugevičiūtė Andželika 
Published: July 2019

Under the current conditions of Economics, in order to keep competition it is necessary to possess not only good economical resources, but also to apply them relevantly in production and this is impossible without good administration in accounting of costs and productions costs. Before the calculation of product cost, first, it is necessary to know which costs and how many of them are included into the indicators of product cost. The validity and objectiveness of the obtained information depend on the preciseness of current cost distribution for the product cost.
Scientific problem – it is unclear how ABC method affects the calculation of partial cost in small companies. It is not clear which method of cost calculation is most beneficial to apply for small companies –it is necessary to research how to distribute indirect costs – either applying ABC system (activity based costing - ABC) or using more simple – traditional distribution methods. The object is ABC method. The aim is to research the application efficiency of ABC method in small companies.
In the first part there are analysed the pieces of research carried out by foreign authors investigating ABC method. There is executed the research in cost calculation in Lithuanian companies in order to identify if companies apply the following method, what benefit they receive and which difficulties they face. Having completed the analysis there were formulated advantages and disadvantages of the following method. In the second part, following the possessed cost calculation data of the company ‘Baldas’ there is compared the cost of the key company’s products calculated under traditional method and applying ABC method. It was indicated if it is useful for a company to apply ABC method for cost calculation.
Methodology for net profitability analysis
Authors: Labonaitė Gintarė , Subačienė Rasa 
Published: July 2019

Every company, regardless of the type or size of business is aiming to achieve the best results. These results are usually related to the profit and the ways to improve it. However, profit line in absolute terms is not sufficient enough as an indicator of the company's performance. Therefore, instruments expressed in profitability ratios are used. While different authors reveal various aspects of the concept of profitability, overall profitability ratios could be assessed as the evaluation of activities‘ results and the relationship of the means used to achieve it.
Net profitability ratio is one of the main cornerstones in the process of company‘s performance evaluation. It provides information on the efficiency of company‘s main, other, financial and investment activities - the final result. In addition, the ratio helps to evaluate efficiency of financial resources management. The analysis of net profitability ratio and factors influencing it may help to determine which element could be adjusted or changed in order to improve the company‘s performance and to gain higher profits.
The article investigates evaluation of net profitability, provides methodology for net profitability analysis, based on the summary of the various authors researches of pyramid systems on influence of various factors to the subject ratios. Methodology of net profitability analysis includes such stages as selection of companies for comparison of information, assessing information sources, application of pyramid analysis system, evaluation of results based on selected company‘s data and data of Department of Statistics, conclusions and suggestions. Chosen ratios of pyramid analysis, which reveal factors affecting the net profitability, reflects aspects of evaluation of efficiency of the assets, equity and current assets to equity ratio. Information collecting, comparison, grouping, systematization, generalization and pyramid analysis methods were used in the research.
Hoaks Dalam Kajian Pemikiran Islam dan Hukum Positif
Authors: Ahmad Supriyadi , Hotimah Husnul 
Published: July 2019

Abstract:Hoaks originating from "focus pocus" originally from Latin "hoc est corpus", means false news. Hoaks also comes from English, namely Hoax, which means fake news. Terminologically, hoax is a false message in an attempt to deceive or influence readers or dealers to believe something, even though the source of the news delivered is completely baseless. Ahead of the Legislative and Presidential Elections in Indonesia 2019, hoaks have entered the political sphere which can threaten the nation's unity and unity. In the perspective of Islamic thought, hoax is a public lie or dissemination of information that is misleading and even defame the other party. The hoax maker is classified as a party that harms others and the hoaxes made are categorized as ifki hadith or false news. Therefore, the perpetrators were threatened with very severe torture. In a positive legal perspective, hoax is a charge of false and misleading news, a content that creates hatred or hostility of certain individuals and/or groups based on ethnicity, religion, race, and between groups (SARA). The culprit can be punished with a maximum of ten years in prison.Keywords: Hoax, Islamic Studies, Positive Law. Abstrak:Hoaks yang berasal dari “hocus pocus” aslinya dari bahasa Latin “hoc est corpus”, berarti berita bohong. Hoaks juga berasal dari Bahasa Inggris Hoax, yang berarti berita palsu. Secara terminologis, hoaks merupakan sebuah pemberitaan palsu dalam usaha untuk menipu atau mempengaruhi pembaca atau pengedar untuk mempercayai sesuatu, padahal sumber berita yang disampaikan adalah palsu tidak berdasar sama sekali. Menjelang Pemilu Legislatif dan Pemilu Presiden di Indonesia tahun 2019, hoaks telah memasuki ranah politik yang dapat mengancam persatuan dan kesatuan bangsa. Dalam perspektif pemikiran Islam, hoaks adalah pembohongan publik atau penyebaran informasi yang menyesatkan dan bahkan menistakan pihak lain. Pembuat hoaks digolongkan sebagai pihak yang merugikan orang lain dan hoaks yang dibuatnya dikategorikan sebagai haditsul ifki atau berita bohong. Oleh karena itu, penyebarnya diancam dengan siksa yang sangat berat. Dalam perspektif hukum Positif, hoaks merupakan muatan berita bohong dan menyesatkan, muatan yang menimbulkan rasa kebencian atau permusuhan individu dan/atau kelompok masyarakat tertentu berdasarkan atas suku, agama, ras, dan antar golongan (SARA). Pelakunya dapat dihukum dengan penjara setinggi-tingginya sepuluh tahun.Kata Kunci: Hoaks, Kajian Islam, Hukum Positif
Keluarga Berencana Perspektif Ulama Hadis
Authors: Sari Emilia 
Published: July 2019

Abstract:Family planning is a slogan in the modern era that dictates community members to plan the number of children to be born in a household. For this reason, pregnancy prevention is carried out with this family planning program. This program is carried out with medical technology tools that are modern and traditional. In the study of Islamic jurisprudence itself, there has been a way to prevent pregnancy behavior by way of Azl, even though it has drawn controversy and differences in views from the jurists. This behavior is considered by some experts as natural family behavior that is permissible. Further discussion will be explained in this paper.Keywords: Family Planning, Hadith, Law Abstrak: Keluarga berencana merupakan suatu slogan di era modern yang mendoktrin anggota masyarakat untuk melakukan perencanaan jumlah anak yang akan dilahirkan dalam suatu rumah tangga. Untuk itu dilakukan penanggulangan kehamilan dengan Program KB ini. Program ini dilakukan dengan alat teknologi kedokteran yang modern maupun dengan cara tradisional. Dalam kajian fiqih Islam sendiri pernah terjadi bagaimana perilaku pencegahan kehamilan dengan cara Azl, walaupun hal tersebut menuai kontroversi dan perbedaan pandangan dari para ahli fikih. Perilaku ini dianggap oleh sebagian ahli sebagai perilaku KB alami yang dibolehkan. Pembahasan lebih lanjut akan dijelaskan dalam makalah ini.Kata Kunci: Keluarga Berencana, Hadis, Hukum
Early-Onset Sepsis Risk Calculator Integration Into an Electronic Health Record in the Nursery
Authors: Stipelman Carole H. , Smith Elizabeth R. , Diaz-Ochu Margarita , Spackman Jennifer , Stoddard Greg , Kawamoto Kensaku , Shakib Julie H. 
Published: July 2019

BACKGROUND AND OBJECTIVES:
An early-onset sepsis (EOS) risk calculator tool to guide evaluation and treatment of infants at risk for sepsis has reduced antibiotic use without increased adverse outcomes. We performed an electronic health record (EHR)–driven quality improvement intervention to increase calculator use for infants admitted to a newborn nursery and reduce antibiotic treatment of infants at low risk for sepsis.

METHODS:
This 2-phase intervention included programming (1) an EHR form containing calculator fields that were external to the infant’s admission note, with nonautomatic access to the calculator, education for end-users, and reviewing risk scores in structured bedside rounds and (2) discrete data entry elements into the EHR admission form with a hyperlink to the calculator Web site. We used statistical process control to assess weekly entry of risk scores and antibiotic orders and interrupted time series to assess trend of antibiotic orders.

RESULTS:
During phase 1 (duration, 14 months), a mean 59% of infants had EOS calculator scores entered. There was wide variability around the mean, with frequent crossing of weekly means beyond the 3σ control lines, indicating special-cause variation. During phase 2 (duration, 2 years), mean frequency of EOS calculator use increased to 85% of infants, and variability around the mean was within the 3σ control lines. The frequency of antibiotic orders decreased from preintervention (7%) to the final 6 months of phase 2 (1%, P &lt; .001).

CONCLUSIONS:
An EHR-driven quality improvement intervention increased EOS calculator use and reduced antibiotic orders, with no increase in adverse events.
RODOLFO STAVENHAGEN, LAS TESIS LATINOAMERICANAS
Authors: Garino Agustina 
Published: July 2019

El libro escrito por Jorgelina Loza, Doctora en Ciencias sociales por la Universidad de Buenos Aires e investigadora asistente del Conicet en el Instituto Gino Germani y FLACSO Argentina, forma parte de la colección Pequeños libros de grandes pensadores de América Latina, editada por la Universidad Nacional de General Sarmiento.1 Esta serie de publicaciones propone presentar una introducción al pensamiento político y social elaborado en nuestra región, ubicando lo latinoamericano2 en el centro del debate y, a su vez, planteando ¿por qué la necesidad de un pensamiento localizado? ¿cuál es la especificidad de lo latinoamericano? ¿por qué es importante reflexionar desde la región ? Con estos interrogantes esta serie de escritos se orienta hacia la construcción de ideas sobre lo común y lo diverso en nuestro territorio y nos invita a pensarnos desde nuestro lugar.
Świadomość działania jako podstawa etycznego wartościowania
Authors: Drożdż Michał 
Published: July 2019

Świadomość działania jako podstawa etycznego wartościowania. Racjonalność człowieka jest fundamentem etyki mediów, zarówno jako punkt wyjścia, jak i jako podstawowe kryterium wartościowania. Jeśli wartościowanie etyczne ma być prawdziwe, autentyczne, słuszne i odpowiedzialne, to musi się oprzeć na pewnym i trwałym fundamencie prawdy o człowieku. Czyn człowieka jest działaniem świadomym i wolnym. Dlatego też wymiar moralny mediów oraz etos medialny są ugruntowane i uwarunkowane świadomością i wolnością działania człowieka. Artykuł niniejszy jest próbą pokazania świadomości działania jako podstawy i kontekstu etycznego wartościowania ludzkich działań medialnych.
Świat wartości prawnych w mediach
Authors: Lizisowa Maria Teresa 
Published: July 2019

Świat wartości prawnych w mediach. Przedmiotem uwagi w niniejszym artykule jest medialny przekaz wartości prawnych. Autorka zaproponowała analizę dyskursu publicznego wokół prawnych wartości normatywnych i prawnych wartości postulatywnych, będących przedmiotem interpretacji w obiegu społecznym oraz w reprezentacji, ocenie i kierowaniu opinią publiczną na ich temat w mediach. W artykule przedstawiła zatem trzy sposoby istnienia wartości, twierdząc, że wartości ustanowione obowiązują w świecie rzeczywistym przy ocenie faktów, ale w mediach są reprezentowane przez nadawców w kontekście demokracji liberalnej, elitystycznej lub uczestniczącej i deliberacyjnej, co umożliwia odbiorcom wybór opcji z jaką mogą się utożsamiać.
Telewizja i film – kanały komunikacji i ewangelizacji w świetle wybranych dokumentów Kościoła katolickiego
Authors: Wożniak-Kot Anna 
Published: July 2019

W odniesieniu zarówno do filmu, jak i do telewizji stosunek Kościoła katolickiego zmieniał się – od negatywnego po pozytywny. Początkowa fascynacja filmem Leona XIII przerodziła się z czasem w niechęć i wrogość: film odciągał ludzi od Kościoła i wypierał z ich umysłów pierwiastki religijne. Przełomem była postawa Piusa XII, który nie zmienił merytorycznie katolickiej nauki o mediach, ale zmienił ton nauczania i spojrzenie na media. Pierwsza transmisja telewizyjna po II wojnie światowej miała miejsce we Francji w 1948 roku. Po tym wydarzeniu Kościół zaproponował swoje rozwiązania dotyczące przygotowania przekazów medialnych, formacji twórców i edukację odbiorców mediów. Artykuł jest syntetycznym ujęciem założeń co do stosowania, roli i korzystania z telewizji i filmu w misji Kościoła. W tym celu zostały przeanalizowane najważniejsze dokumenty Kościoła na temat mediów, opublikowane po soborze watykańskim II, oraz orędzia papieskie publikowane na Światowe Dni Środków Społecznego Przekazu.
PENGGUNAAN MEDIA AUDIO VISUAL DALAM PEMBELAJARAN MENYIMAK DONGENG DI ERA DIGITAL
Authors: Nurani Riga Zahara , Nugraha Fajar , Sidik Geri Syahril 
Published: July 2019

Abstract: Learning in the 21st century is inseparable from the influence of digital technology. Learning listening of fairy tale with conventional method (teachers read a fairy tale in front of the class) is no longer suitable to be applied for the students in this digital era, so that a new breakthrough in the use of learning media is needed. Learning listening of fairy tale by using an audio visual media can be one of alternatives used by teachers. Research used an audio visual media in learning listening of fairy tale was conducted in SDN 6 Singaparna. Research method used is descriptive qualitative method. The enthusiasm of students in learning listening of fairy tale by using audio visual media is better than learning listening of fairy tale read by the teacher. This is seen from the average score of listening ability of student’s fairy tales. The average listening ability of student’s fairy tale using audio visual media is 84,53, while the average listening ability of student’s fairy tale before the research was 67,20. In addition to making the average listening ability of student’s fairy tale increased was by the use of audio visual media that also made students more active in the learning process. This is seen when the teacher asked a few questions when the fairy tale has been played, most students responded well to the questions given by the teacher. Abstrak: Pembelajaran di abad ke-21 ini tidak terlepas dari pengaruh teknologi digital. Pembelajaran menyimak dongeng dengan cara konvensional (guru membacakan dongeng di depan kelas) dirasa sudah tidak cocok lagi diterapkan pada siswa di era digital ini, sehingga diperlukan adanya terobosan baru dalam penggunaan media pembelajaran. Pembelajaran menyimak dongeng dengan menggunakan media audio visual dapat menjadi salah satu alternatif yang bisa digunakan oleh guru. Penelitian tentang penggunaan media audio visual dalam pembelajaran menyimak dongeng dilakukan di SDN 6 Singaparna. Metode penelitian yang digunakan adalah metode deskriptif kualitatif. Antusiasme siswa dalam pembelajaran menyimak dongeng dengan menggunakan media audio visual lebih baik daripada pembelajaran menyimak dongeng yang dibacakan langsung oleh gurunya. Hal ini terlihat dari rata-rata kemampuan menyimak dongeng siswa. Rata-rata kemampuan menyimak dongeng siswa setelah menggunakan media audio visual adalah 84,53, sedangkan rata-rata kemampuan menyimak dongeng sebelumnya hanya 67,20. Selain membuat rata-rata kemampuan menyimak dongeng siswa meningkat, penggunaan media audio visual juga membuat siswa lebih aktif dalam proses pembelajaran. Hal ini terlihat saat guru mengajukan beberapa pertanyaan saat dongeng telah diputar, sebagian besar siswa merespon dengan baik pertanyaan-pertanyaan yang diberikan oleh guru.
INFLUENCE OF CONCRETE-PICTORIAL-ABSTRACT (CPA) APPROACH TOWARDS THE ENHANCEMENT OF MATHEMATICAL CONNECTION ABILITY OF ELEMENTARY SCHOOL STUDENTS
Authors: Putri Hafiziani Eka , Misnarti Misnarti , Saptini Ria Dewi 
Published: July 2019

Abstract:. The study aims to examine the influence of CPA learning approach towards the enhancement of mathematical connection ability of elementary school students. The present research is a quasi experiment using pretest and posttest design controls in Mathematics applied to 39 elementary school students in Purwakarta, West Java, Indonesia. The results of the study show that mathematical connection ability of elementary school students who were taught using CPA learning approach is enhanced than the elementary school students who were taught using conventional learning as a whole group of high and low achiever students according to their mathematical prior ability. Abstrak: Penelitian ini bertujuan untuk menguji pengaruh pendekatan pembelajaran CPA terhadap peningkatan kemampuan koneksi matematika siswa sekolah dasar. Penelitian ini adalah kuasi eksperimen dengan menggunakan kontrol desain pretest dan posttest dalam Matematika diterapkan kepada 39 siswa sekolah dasar di Purwakarta, Jawa Barat, Indonesia. Hasil penelitian menunjukkan bahwa kemampuan koneksi matematika siswa sekolah dasar yang diajarkan menggunakan pendekatan pembelajaran CPA lebih meningkat daripada siswa sekolah dasar yang diajar menggunakan pembelajaran konvensional secara keseluruhan dalam kelompok siswa berprestasi tinggi dan rendah sesuai dengan kemampuan matematika mereka sebelumnya.