bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lateral Force Transfer Mechanism of Staggered Truss Structures Influenced by Floor Slab Stiffness
Authors: Wang Yumei , Yu Kejie 
Published: December 2024

Abstract

Staggered truss structures are gaining more attentions due to their double-span spaces and adaptability in the industrialized age. However, the role of floors on the force transfer still needs more parameter analysis. This paper used three structural units to study the floor actions: the first case focuses on the shear distribution among different trusses on floors with full rigidity, full-flexibility, openings and diaphragm constraints; the second case focuses on the shear distribution among truss members with different joint restrictions; the third case focuses on the plastic hinge development and failure mode for floors with different stiffness reduction factors. Results showed that, rigid floors with diaphragm constraints coordinate different plane trusses well, but put large demands in the open corridor sections; while flexible floors are unfavorable to non-truss columns; all-fixed-joint model causes large shear and bending in all truss members; all-hinged-joint model softens the whole structure and induces large shear in the 1st story; fixing the chords’ joints could decrease the member forces and improve the overall structural performance. Effective lateral force transfer measures, either continuous chords or appropriate rigidity of floors, are key to ensure the seismic performance and favorable failure modes of staggered truss structures.
Classification of schizophrenia spectrum disorder using machine learning and functional connectivity: reconsidering the clinical application
Authors: Li Chao , Chen Ji , Dong Mengshi , Yan Hao , Chen Feng , Mao Ning , Wang Shuai , Liu Xiaozhu , Tang Yanqing , Wang Fei , Qin Jie 
Published: December 2024

Abstract

Background Early identification of Schizophrenia Spectrum Disorder (SSD) is crucial for effective intervention and prognosis improvement. Previous neuroimaging-based classifications have primarily focused on chronic, medicated SSD cohorts. However, the question remains whether brain metrics identified in these populations can serve as trait biomarkers for early-stage SSD. This study investigates whether brain metrics identified in chronic, medicated SSD can function as trait biomarkers for early-stage SSD.Methods Data were collected from 502 SSD patients and 575 healthy controls (HCs) across four medical institutions. Resting-state functional connectivity (FC) features were used to train a Support Vector Machine (SVM) classifier on individuals with medicated chronic SSD and HCs from three sites. The remaining site, comprising both chronic medicated and first-episode unmedicated SSD patients, was used for independent validation. A univariable analysis examined the association between medication dosage or illness duration and FC.Results The classifier achieved 69% accuracy (P = 2.86e-13), 63% sensitivity, and 75% specificity when tested on an independent dataset. Subgroup analysis showed 71% sensitivity (P = 4.63e-05) for chronic medicated SSD, but poor generalization to first-episode unmedicated SSD (sensitivity = 48%, P = 0.68). Univariable analysis revealed a significant association between FC and medication usage, but not disease duration.Conclusions Classifiers developed on chronic medicated SSD may predominantly capture state features of chronicity and medication, overshadowing potential SSD traits. This partially explains the current classifiers' non-generalizability across SSD patients with different clinical states, underscoring the need for models that can enhance the early detection of schizophrenia neural pathology.
Sleep quality and nighttime sleep duration mediated the association between occupational stress and work-related musculoskeletal disorders among bus drivers
Authors: Wang Yuxi , Weng Shaofan , Lin DaFeng , Chen Shengli , Zhou Wei , Guo Huan , Zhang Naixing 
Published: December 2024

Abstract

Background
Work-related musculoskeletal disorders (WMSDs) significantly affect bus drivers’ health and warrant adequate attention. This study aimed to explore the associations of occupational stress with WMSDs among bus drivers, and assess the potential mediating role of sleep quality and nighttime sleep duration.
Methods
A total of 1792 bus drivers with the available information from 5 subsidiaries of Shenzhen Bus Group by convenient sampling method were included. Logistic regression model was used to estimate the associations of occupational stress, sleep quality and nighttime sleep duration with WMSDs. Mediation analysis was performed to explore the role of sleep quality and nighttime sleep duration in the association between occupational stress and WMSDs.
Results
The prevalence rate of single-site, multiple-site, and overall WMSDs among bus drivers were 10.04%, 59.26%, and 69.31%, respectively. Compared to participants without occupational stress, those with occupational stress showed a 92% higher risk of multiple-site WMSDs and a 1.03-fold elevated risk of overall WMSDs [OR (95% confidence interval, CI) = 1.92 (1.56, 2.36) and 2.03 (1.63, 2.55), respectively]. Bus drivers with poor sleep quality had a 3.73-fold risk of multiple-site WMSDs and 4.82-fold risk of overall WMSDs than those in high sleep quality [OR (95% CI) = 3.73 (2.89, 4.84) and 4.82 (3.53, 6.71), respectively]. Each 1-hour increment in nighttime sleep duration was linked to a 36% declined risk of multiple-site WMSDs and a 37% reduced risk of overall WMSDs [OR (95% CI) = 0.64 (0.58, 0.71) and 0.63 (0.57, 0.70), respectively]. Further mediation analysis indicated that poor sleep quality and decreased nighttime sleep duration partly mediate the associations between occupational stress and risk of both multiple-site and overall WMSDs.
Conclusion
Occupational stress and poor sleep quality significantly elevated the risk of both multiple-site and overall WMSDs, while increased nighttime sleep duration was associated with a reduced risk of multiple-site and overall WMSDs. Sleep quality and nighttime sleep duration could partly mediate the relationship between occupational stress and both multiple-site and overall WMSDs. Highlighting the importance of reducing occupational stress, maintaining good sleep quality and sufficient nighttime sleep duration for WMSDs prevention.
Single Versus Double Symphyseal Plating in Management of Vertically Unstable Tile C1-2 and C1-3 Pelvic Ring Injuries: A Randomized Controlled Trial
Authors: Moussa Islam Sayed , Abdelmonem Ibrahim Mahmoud , Nagy Amr Mohammed 
Published: December 2024

Abstract

Background: Single superior symphyseal plating is the most effective method for managing vertically unstable Tile C1-2 and C1-3 pelvic ring injuries.However, high rates of implant failure were more frequently observed in obese patients (body mass index< 30). The study aimed to determine the potential reduction in implant failure rates by adding an anterior symphyseal plate in obese patients (class I).
Methods: The study was designed as a prospective, randomized controlled trial with a single-blind methodology, conducted at a level 1 trauma center.The study involved 36 patients with Tile C1-2 and C1-3 injuries, and class I obesity between February 2022 and May 2023. All cases had posterior and anterior ring fixation, with 18 cases having superior symphyseal plating and 18 cases having additional anterior plating (Groups A and B). The primary outcomes were radiological, functional outcomes, and implant failure rates.
Results: Patients in group A were followed up for an average of 13.39 months, and those in group B for 13.7 months. Group A exhibited a significantly shorter operative time with a mean difference of 30 minutes (p < 0.001), as well as lower reoperation rates (p = 0.03). Both groups had similar final clinical and radiological outcomes (p = 0.44 and 0.78) and implant failure rates (p = 0.18) at the last follow-up.
Conclusion: The authors found that using a single high-quality symphyseal plate effectively addresses symphyseal diastasis in vertically unstable Tile C1-2 and C1-3 pelvic ring injuries among patients with class I obesity. This method lowers morbidity by reducing operation times and minimizing reoperation rates, while the inclusion of an additional anterior plate does not enhance the final radiological and clinical outcomes.
Level of Evidence: Therapeutic Level I study.
Trial registration: Ain Shams University's ethical committee retrospectively registered and approved this trial (FWA 000017585 FMASU R65/2022). It was organized and operated according to the guidelines of the International Council on Harmonization (ICH) in Anesthesiology and the Islamic Organization for Medical Sciences (IOMS). The United States Office for Human Research Protections and the United States Code of Federal Regulations operate under Federal Wide Assurance No. 000017585 (retrospectively registered). Our study was registered at ClinicalTrials.gov with clinical trial number NCT06439108.
Evaluating the Effectiveness of a Multidisciplinary Virtual Clinic for Post-ICU Survivors: A Prospective Observational Study Protocol
Authors: Aljuhani Ohoud , Suilaman Khalid Al , Algethamy Haifa Mesfer , AlFaifi Mashael , Alharthi Abdullah F. , Alqahtani Rahaf A. , Alsohimi Samiah Abdullah , Abudayah Fatimah , Alballaa Rashid , Alarifi Mohammed , Alshehri Asma , Alhommod Abdulaziz 
Published: December 2024

Abstract

The global ICU patient survival rate has increased dramatically due to advancements in critical care practices and technology; yet, post-ICU survivors frequently struggle with post-ICU syndrome (PICS), significantly affecting their overall health and well-being (Needham et al., 2012). The lack of structured post-ICU care in Saudi Arabia, coupled with a growing aging population and the ambitious Saudi Vision 2030, highlights the urgency of establishing innovative healthcare solutions.
This protocol introduces a multidisciplinary virtual (tele) post-ICU follow-up clinic designed to address the unmet needs of ICU survivors. The clinic employs advancements in telemedicine, digital health, and multidisciplinary care to deliver comprehensive, accessible, and cost-effective support. Objectives include improving survivors' quality of life, reducing healthcare utilization, and enhancing care equity. Quantitative and qualitative methods will assess outcomes such as quality of life, cognitive and psychological recovery, and healthcare cost savings. This initiative not only addresses a critical gap in the healthcare system but also aligns with national goals to improve health outcomes and life expectancy.
Почвенные условия и состояние зеленых насаждений Южно-Приморского парка в Санкт-Петербурге
Authors: Двадцатова Т. В. , Изотова Т. В. , Мельничук И. А. , Часовская В. В. 
Published: December 2024

Статья посвящена изучению современного состояния почвы и насаждений Южно-Приморского парка в Санкт-Петербурге. Парк создан на намывных грунтах и на сегодняшний день является одним из крупнейших элементов воднозеленого каркаса Петербурга. Авторы проследили динамику формирования почвенного слоя (по данным 1974, 2004 и 2024 гг.). Выявлено, что происходит постепенное уплотнение нижних намывных горизонтов, что плохо сказывается на гидрологических условиях территории. При этом верхние – насыпные – горизонты постепенно увеличивают свою мощность и удерживают плодородие за счет постоянной хозяйственной деятельности человека. Видовое разнообразие древесно-кустарниковой растительности изменилось несущественно: утрачены некоторые декоративные виды, высаженные единично; отмечено появление аборигенных видов, устойчивых к неблагоприятным условиям среды, в первую очередь, к уплотнению почв и избыточному увлажнению. Состояние насаждений имеет тенденцию к ухудшению – общее ослабление растений по причине возросшей рекреационной нагрузки.
The article focuses on studying the current condition of the soil and plantings in Yuzhno-Primorskiy Park in St. Petersburg. The park was created on reclaimed soils and is currently one of the largest elements of St. Petersburg's water-green framework. The authors tracked the dynamics of soil layer formation (based on data from 1974, 2004, and 2024). It was found that there is a gradual compaction of the lower reclaimed horizons, which negatively affects the hydrological conditions of the area. At the same time, the upper – filled – horizons are gradually increasing in thickness and retaining fertility due to continuous human activity. The species diversity of woody and shrub vegetation has changed insignificantly: some ornamental species, planted singly, have been lost; there has been an emergence of indigenous species that are resistant to adverse environmental conditions, primarily to soil compaction and excessive moisture. The condition of the plantings tends to deteriorate – an overall weakening of plants due to increased recreational load.
Эффективность комбинации бортезомиба, леналидомида и дексаметазона в качестве индукционной терапии у больных множественной миеломой, осложненной терминальной почечной недостаточностью
Authors: Семочкин Сергей Вячеславович , Желнова Е. И. , Казей В. И. , Черкасова А. В. , Никифорова А. Г. , Фролова Н. Ф. , Барях Е. А. , Яцков К. В. , Каримова Е. А. , Котенко О. Н. , Мисюрина Е. Н. 
Published: December 2024

AIM. To analyze our own experience in the use of the VRd regimen in the induction therapy for patients with newly diagnosed multiple myeloma (MM) complicated by the end-stage renal disease (ESRD).
MATERIALS & METHODS. This prospective cohort trial enrolled 15 newly diagnosed MM patients with ESRD (eGFR < 15 mL/min/1.73 m2) in the period from February to October 2019. Six original RVd induction cycles were planned: lenalidomide 25 mg per os on Days 1, 4, 8, 11, and 15 (administered after hemodialysis), bortezomib 1.3 mg/m2 subcutaneously on Days 1, 4, 8, and 11, as well as dexamethasone 20 mg per os or IV on Days 1, 2, 4, 5, 8, 9, 11, and 12. Blood sampling for pharmacokinetic analysis was performed in 5 (33 %) patients prior to therapy (end-point 0) as well as 4, 24, and 96 hours after the first lenalidomide dose during the 1st RVd cycle.
RESULTS. The median age of patients was 67 years (range 55–74 years); there were 9 women and 6 men. All of them were hemodialysis-dependent. The median GFR was 6.3 (5.7; 12.5) mL/min/1.73 m2. In all patients, the serum β2-microglobuline concentration was > 5.5 mg/L (ISS III = 100 %). In 4 (26.7 %) out of 15 patients, renal response was achieved (group I), whereas 11 (73.3 %) patients showed no renal recovery and remained hemodialysis-dependent (group II). Overall (hematologic) response was 80 % (CR 26.7 %, VGPR 20 %, PR 33.3 %). With the median follow-up of 4.64 years, the 5-year overall survival (OS) in all 15 patients was 33.3 ± 12.2 %. In group I (n = 4), life expectancy of patients was 4.45+, 1.81, 4.93+, and 4,68+ years. Out of them, 3 patients are being further followed-up, one died. In group II (n = 11; 9 events), the median OS was 1.75 years. The median maximum serum lenalidomide concentration as reported 4 hours after the first dose of the drug administration was 470 (364; 496) ng/mL. After 24 hours, the lenalidomide concentration decreased 5.7-fold to 82 (54; 269) ng/mL.
CONCLUSION. The proposed original VRd regimen ensures high rates of overall response (80 %) and deep remissions (³ VGPR 46.7 %). The originality of the VRd regimen consisted in intermittent administration of 25 mg lenalidomide on Days 1, 4, 8, 11, and 15 after hemodialysis reaching a cumulative dose of 125 mg per 21-day cycle. The maximum lenalidomide concentration (Cmax) did not exceed that in patients with normal renal function and gradually decreased by the next hemodialysis session and the next drug administration. The incidence and severity of adverse events did not exceed those resulting from similar regimens for treatment of hemodialysis-dependent MM patients with ESRD.
Разработка и апробация электронной системы «ЭД-Сам» для мониторинга состояния пациентов с гематологическими злокачественными опухолями на основании данных о качестве их жизни
Authors: Никитина Татьяна Павловна , Мельниченко В. Я. , Федоренко Д. А. , Саржевский В. О. , Банникова А. Е. , Богатырев В. С. , Мамедова А. A. , Мочкин Н. Е. , Панченко А. К. , Рукавицын А. А. , Самойлова А. А. , Шорохов Н. С. , Порфирьева Н. М. , Ионова Т. И. 
Published: December 2024

BACKGROUND. Over the past years, digital technologies have been increasingly used worldwide for monitoring patient-reported assessment data in real-world clinical practice. Electronic systems allow to automatically assess a patient’s perception of disease and therapy in a convenient mode, remotely, and with obvious savings in time and resources.
AIM. To develop and test the domestic electronic system for monitoring the health status of patients with hematologic malignancies based on their quality-of-life data.
MATERIALS & METHODS. At the first stage, the electronic system was developed on the basis of a secure internet resource using two special questionnaires HM-PRO and HADS. Patients with hematologic tumors completed electronic questionnaires on admission to the hospital, after treatment, and remotely at different times after discharge. The data was processed by descriptive statistics.
RESULTS. The interactive electronic system “Health – Electronic Self-Assessment” (HESA) was developed so that a graphic representation of the patient-reported real-time questionnaire data is provided for both patients and doctors. The testing of HESA included 115 patients (the mean age of 44 years; 63 women) with various hematologic tumors treated with high-technology medical services. Half of the patients completed the questionnaires remotely at different times after hospital discharge. Using HESA, clinicians were able to remotely monitor the changes in various quality-of-life aspects and psychological issues relying on diagrams, summary results, and patients’ comments.
CONCLUSION. The first domestic electronic system HESA was developed for monitoring the health status of oncohematologic patients based on their quality-of-life data. We have shown that HESA can well be regarded as a valuable tool to inform hematologists on the state of their patients during hospitalization and most importantly during remote follow-up after discharge. It can contribute to further promotion of the patient-oriented approach in medicine and improvement of medical care quality for one of the most challenging categories of oncohematologic patients.
Новая коронавирусная инфекция COVID-19 и состояние гуморального иммунного ответа у пациентов с гематологическими злокачественными опухолями
Authors: Игнатьева Елена Валентиновна , Рукавицын О. А. , Казаков С. П. 
Published: December 2024

AIM. To study the baseline condition of the humoral component in the adaptive immune system and its changes in patients with hematologic malignancies who received the standard chemotherapy with and without monoclonal antibodies (mAb) after a COVID-19 infection.
MATERIALS & METHODS. The study enrolled 51 patients with hematologic malignancies (AL, NHL, cHL, MM, CMPN). They were treated at the NN Burdenko Main Military Clinical Hospital. Patients were aged 24–84 years (median 50.6 years); there were 14 women and 37 men. The control group consisted of 16 healthy medical professionals working at the hospital who had had COVID-19. The main group included a subgroup of patients (n = 21) treated with mAb chemotherapy. In all patients, blood serum was tested for anti-SARS-CoV-2 antibodies of different classes.
RESULTS. Significant differences were identified while assessing the level of IgG antibodies to SARS-CoV-2 S1-protein in lymphoma and multiple myeloma patients (median 431 BAU/mL vs. 667 BAU/mL; p < 0.05) as well as in patients with lymphomas and chronic myeloproliferative neoplasms (median 431 BAU/mL vs. 705 BAU/mL; p < 0.05). The juxtaposition of the control (n = 16) and main (n = 51) groups showed that their median levels of anti-SARS-CoV-2 IgG antibodies did not differ and accounted for 15.7 units. In the groups of patients with (n = 21) and without (n = 30) mAb chemotherapy, by the semi-quantitative method, the median levels of IgM/IgG antibodies to the S1-protein receptor-binding domain and SARS-CoV-2 nucleocapsid proteins accounted for 10.1 units vs. 16.1 units (p < 0.05). In the same groups of patients, the quantitative method yielded the median levels of anti-SARS-CoV-2 S1-protein IgG antibodies of 433 BAU/mL and 595 BAU/mL, respectively (p < 0.05).
CONCLUSION. Patients with hematologic malignancies show a decline in the levels of anti-SARS-CoV-2 S-protein IgG antibodies. Non-recipients of mAb chemotherapy have a higher level of anti-SARS-CoV-2 IgG antibodies. Patients with an indication for mAb chemotherapy (rituximab and obinutuzumab) need to be protected from COVID-19 by means of epidemiological preventive measures. One of them is anti-SARS-CoV-2 vaccination prior to mAb chemotherapy onset or post-exposure prophylaxis with recombinant humanized IgG mAbs tixagevimab + cilgavimab.
Open versus arthroscopic fusion of the subtalar joint: a randomized controlled trial
Authors: Stegeman Mark , Pruijn Nathalie , Susan Saskia , Heesterbeek Petra J C , Louwerens Jan Willem K 
Published: December 2024

Background and purpose: Our primary aim was to compare the early complication rate (< 6 weeks postoperatively) after open or arthroscopic fusion of the subtalar joint. Secondary outcomes included late complications (> 6 weeks postoperatively), function, pain, and patient satisfaction.Methods: In this prospective randomized controlled trial, patients listed for subtalar joint fusion were included and randomized for open or arthroscopic fusion. Complications were assessed at scheduled visits at 2 and 6 weeks, 3, 6, and 12 months postoperatively. Functional scores, pain scores, and patient satisfaction were assessed at 3, 6, and 12 months postoperatively, and PROMS at baseline (preoperatively), 3, 6, and 12 months postoperatively. The scores were compared over time between the groups using Fisher’s exact test and linear mixed models.Results: 51 patients were included between 2013 and 2020, of whom 25 were allocated to open and 26 to arthroscopic fusion. 3 early complications (2 sural nerve lesions, 1 infection) occurred in the open fusion group (12%; 95% confidence interval [CI] 3–32) and 3 (2 wound healing problems, 1 screw exchange) in the arthroscopic group (12%; CI 3–31). Late complications included screw removal (n = 5) in the open fusion group versus screw removal (n = 5), non-union (n = 2), bony prominence/calcification removal (n = 1), sural nerve lesion (n = 1), lesion of the calcaneal branch of the tibial nerve (n = 1), complex regional pain syndrome type II (n = 1), and secondary plantar fasciitis (n = 1) in the arthroscopic fusion group. No superiority of arthroscopic over open fusion was found regarding early (P = 1.0) and late complications (P = 0.2), function and pain scores, and patient satisfaction over 12 monthsConclusion: Arthroscopic fusion did not result in fewer early complications compared with open fusion. Secondary outcomes did not differ significantly between the approaches.