bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrological and physicochemical parameters associated with SARS-CoV-2 and pepper mild mottle virus wastewater concentrations for a large-combined sewer system
Authors: Nguyen Thanh Luan , Hachad Mounia , McQuaid Natasha , Krylova Kateryna , Thanh Loan Nguyen Ha , Visentin Flavia , Burnet Jean-Baptiste , Quete Fernando Sanchez , Maere Thomas , Tsitouras Alexandra , Vanrolleghem Peter , Frigon Dominic , Loeb Stephanie , Dorner Sarah , Goitom Eyerusalem 
Published: February 2025

ABSTRACT
During COVID-19, surveillance of SARS-CoV-2 in wastewater has been a promising tool for tracking viral infection at the community level. However, in addition to the shedding rates within the community, SARS-CoV-2 concentrations in raw wastewater are influenced by several environmental factors. This study investigated the effects of wastewater characteristics on the viral quantification of SARS-CoV-2 and pepper mild mottle virus (PMMoV) for a large wastewater system with combined sewers. Principal component analysis illustrated that water temperature negatively correlates with SARS-CoV-2 and PMMoV in wastewater, but flow rate and EC are highly correlated with SARS-CoV-2 in spring and winter. The normalization using EC enhanced the correlation with clinical data compared to normalization using pH, flow rate, and raw SARS-CoV-2. The normalization using PMMoV reduced the correlation with clinical data. Multiple linear and random forest (RF) applied to predict the concentrations of SARS-CoV-2 in wastewater, given the confirmed cases and physicochemical parameters. RF regression was the best model to predict SARS-CoV-2 in wastewater (R2=0.8), with the most important variables being the confirmed cases followed by water temperature. RF model is a potent predictor of the presence of SARS-CoV-2 in wastewater. This enhances the degree of reliability between community outbreaks and SARS-CoV-2 monitoring.
Recent Advancement in Drug Targeting Therapies in the Treatment of Pancreatic Cancer
Authors: Harwansh Ranjit K , Hamid Junainah Abd , Wal Pranay , Deshmukh Rohitas , Patra Pratap Kumar , Gasmi Amin 
Published: February 2025

Objective of the Study:
This review aims to critically analyze the scope for targeting drugs towards
the treatment of improving outcomes in PDAC, focusing on DNA repair inhibitors, antiangiogenic therapy, inhibitors
of the KRAS pathway, anti-stromal, and nanoparticle-based therapy.

Materials and Methods:
A critical review of preclinical and clinical studies was conducted to summarize the
therapeutic interventions that target specific mutations in PDAC, components of the tumor microenvironment,
and drug delivery systems, especially nanotechnology, to enhance targeting and efficacy.

Results:
Inhibitors and nanotechnology-based targeted therapies have reported promise in preclinical models:
drug delivery is enhanced with the loss of PDAC resistance mechanisms. Formulations and combinations targeting
KRAS as well as other pathways point toward improved drug delivery over 'orthodox' treatment approaches.

Conclusion:
This review concludes that although improvement in therapies for PDAC has incrementally been
proven in recent literature, however, more research is expected to enhance these approaches so that they can
be applied appropriately at the clinical stage. In future studies, it is expected to optimize treatment combinations,
address mechanisms of resistance, and improve the delivery of drugs.
Synthesis of N-Heterocycles and Linear Adducts from Allyl-Containing Substrates and Sulfonamides
Authors: Ganin Anton S. , Sobyanina Mariya M. , Moskalik Mikhail Yu. 
Published: February 2025

Abstract:
The review describes the oxidative addition of sulfonamides to allylic derivatives. The direction of
the sulfonamidation reaction depends on various factors, such as the type of allylic substrate, solvent, oxidant,
and the reactivity of the sulfonamide. Intramolecular cyclization of allyl sulfonamides is a simple method for
obtaining nitrogen-containing heterocyclic compounds with diverse structures. Reactions between O-allylic
substrates and sulfonamides in the presence of oxidizing agents can produce cyclic or linear amino ethers,
which are valuable for the synthesis of heterocyclic biologically active compounds. N-allylic substances are
excellent starting materials for the synthesis of N-heterocyclic compounds and linear products with two or three
amino groups, providing ample opportunities for further functionalization. When allylsilanes are exposed to
oxidizing conditions, they undergo desilylation, allowing for the introduction of an allylic group into reactions
with sulfonamides, resulting in products free from Si-heteroatoms, based on a C3-allylic scaffold and sulfonamide
nitrogen. The choice of reaction medium and oxidizing agent can significantly affect the course of the
reaction, leading to the formation of different products. The main products include aziridines, pyrrolidines, piperazines,
lactams, oxazolidines, amino ethers, amidines (imidazoline precursors), and products of aminohalogenetation.
This review provides a comparative analysis of the reactivity of sulfonamides in oxidative addition
reactions and considers the advantages and disadvantages of synthetic methods.
Impact of Pre-Lockdown Hyper-Energy on Mood and Rhythm Dysregulation in Older Adults During the COVID-19 Pandemic
Authors: Primavera Diego , Kalcev Goce , Bert Fabrizio , Cantone Elisa , Perra Alessandra , Tusconi Massimo , Pinna Samantha , Orrù Germano , Scano Alessandra , Tramontano Enzo , Barbov Ivan , Nonnis Marcello , Nardi Antonio Egidio , Cossu Giulia , Sancassiani Federica , Carta Mauro Giovanni 
Published: February 2025

Objective
The aim of this work is to verify whether a cohort of elderly people with hyper-energy tended to increase depressive symptoms and misaligned social and personal rhythms during the lockdown compared to a cohort of older adults without hyper-energy one year before the lockdown.

Methods
The two cohorts were evaluated in April 2019 (T0) and in April 2020 (T1). Hyper-energy, cognitive performance, depressive symptoms, and social and personal rhythms were evaluated at T0 and T1.

Results
In the measure of the Brief Social Rhythm Scale (BSRS) score, the differences between groups in the two observation times reach statistical significance. The sub-group with previous hyper-energy at T0 but no longer having hyper-energy at T1 increases the score by more than 5 points (a higher score indicates greater rhythm dysregulation, thus having a worse regulation of rhythms at T1), while in those individuals who didn’t have hyper-energy, the score remains substantially unchanged (+0.06). However, if the increase in the score from T0 and T1 is measured, both groups with hyper-energy at T0 presented a greater mean increase compared to people who did not have hyper-energy at T1. In the total of the eleven elderly people with hyper-energy at T0, the mean increase in BSRS score was 1.05±1.19 versus 0.06±0.98 (F=9.407, P=0.003), and in people who no longer had hyper-energy at T1, it was 1.05±1.19 versus 5.50±3.83 (F=105.0, P<0.0001). In people with hyper-energy at T0, the mean increase in the Patient Health Questionnaire-9 (PHQ-9) score was 0.72±0.75 versus 0.01±0.28 (F=37.153, P<0.0001). The gain was even higher in people who no longer had hyper-energy at T1, 1.38±1.03 vs. 0.01±0.28 (F=87.386, P<0.0001). An inverse linear correlation was found between energy perception (measured as the score of Item 10 of SF-12) and the score of PHQ-9 measuring depressive symptoms both at T0 and, more strongly, at T1, as well as with the BSRS scores, but only at T1.

Conclusion
The study, despite the limitations of a small sample, seems to confirm a greater vulnerability to the lockdown situation in people with hyperactivity, even in the absence of psychopathology (i.e., part of the bipolar spectrum).
Oral Microbiome Modulates Tumor Micro-Environment Potentiating Oral Cancer Progression from Benign Stages- A Scoping Review
Authors: Goswami Gargi Roy , Patil Rujuta , Ghosh Somedatta , Kaur Geetpriya , Banerjee Abhijit G. 
Published: February 2025

Background:
Oral Squamous Cell Carcinomas (OSCC) are one of the common causes
of death globally. Several etiological factors cause OSCC, including alcohol, tobacco use, poor
oral hygiene, Human Papilloma Virus (HPV) infections, Yeast (Candida spp.) infections, etc.
Oral microbial dysbiosis and inflammatory conditions like periodontitis have also been implicated
recently. The host-microbiome interactions may further alter the homeostasis of the oral Tumor
Microenvironment (TME). In this review, we aim to determine the role of resident microbiota in
oral cancer progression and decipher how they interact with the TME. The article also discusses
potential biomarkers and therapeutic targets to enhance the management of OSCC.

Methods:
PubMed, Medline, and Google Scholar were used as biomedical literature databases.
The following keywords were looked up for academic literature using Boolean operators. Initially,
a total of 273 articles were found as a result of the literature search.

Results:
Finally, 142 articles that met the exclusion and inclusion criteria were chosen for literature
review,as depicted in the PRISMA flowchart (Fig. 1).

Discussion:
Multiple oral bacterial species are linked to OSCC. Modulation immunotherapies
that target the TME and reverse oral microbiota dysbiosis have been proposed in recent investigations.
Changes in the oral microbiota have an impact on the oral microenvironment, leading to inflammatory
cell infiltration, cytokine release, and chronic inflammation. All the data support an
immunosuppressive TME. Antifungal and antibacterial medications are currently advised for the
treatment.

Conclusion:
We conclude that the utilization of microbial biomarkers and generated products as
potential anticancer targets could be one of the methods for mitigating oral cancer. Tumor immunotherapies
are the newest method for treating cancer patients. However, there are still a lot of
drawbacks. We attempted to outline the possible approaches to potential immunotherapies.
Blåleire og brunleire fra Enebakk leireuttak
Authors: Sigrid Espelien  
Published: February 2025

Denne leira og beholderen representerer blåleire som en del av et industrilandskap i prosjektet.
keywords: blåleire, kunstnerisk forskning, clay, blueclay, artistic resaerch, teglindustri, enebakk leireuttak, blåleire og brunleire fra enebakk leireuttak, leca fabrikken, LECA, ravinelandskap, brunleire, ekstraktiv industri
Samtale med tidligere fabrikksjef på Bratsberg teglverk John Arne Rinde 04.10.2022
Authors: Sigrid Espelien  
Published: February 2025

Samtale med tidligere fabrikksjef på Bratsberg teglverk John Arne Rinde 04.10.2022. Bø i Telemark.
keywords: blåleire, murstein, tegl, kunstnerisk forskning, clay, brick, blueclay, artistic resaerch, brick industry, teglindustri, teglhistorie, brick history, Bratsberg teglverk, kroppslig kunnskap, situert kunnskap
Psychoanalysis for the Virtual Reality
Authors: Tolga Theo Yalur  
Published: February 2025

Psychoanalysis is always targeted in theory with armchair theorizing. A very distorted sense of the phenomena from the armchair introspection and speculation and almost-limited theorizing in behavioral psychologies and even in psychoanalysis invests itself in human experiential stances instead of objective observation. To construct a theory based upon these phenomena, however, there’s too much data. What psychoanalysts do is to demonstrate to the people, through self-experiments, how simple it is to misunderstand what is actually in their consciousness and in their first-person data. What’s remarkable about consciousness is that it is not continuous. There are countless voids in the information of consciousness, some of which work in the psychoanalytic experience of diagnosing symptoms in first- person data, the beliefs about the experiences to which individuals have exclusive access. Its discontinuity, the voids and the holes are limited to these beliefs. For the fact that language works discursively, humans may renounce their privileged access to these experiences and shift their focus from what they believe to what actually is the case. In the end, there will be a scientific narrative in which the conscious self will not be a character. A living body, a living brain, and everything else is all that exists. The first-person narrative would be extracted from that third-person account. The conscious self never exists in any other sense. Thinking that it would exist is the illusion.
keywords: psychoanalysis, virtual reality, Discourse
Digital Safety Monitoring System for Auto Repair Company
Authors: Egelsky V. V. , Nikolaev N. N. , Egelskaya E. V. , Panfilova E. A. 
Published: February 2025

Introduction. The scientific literature discusses the potential of artificial intelligence (AI) for ensuring industrial safety. Risk control methods are considered and recommendations for incident prevention are given. The relationship between the competencies of lifting crane operators and the probability of accidents has been studied. Examples of using neural networks for determining the reliability of removable lifting devices are presented. Remote monitoring of operational safety is described. However, the use of AI to manage risks in a car repair station has not been sufficiently studied. This research aims to address this gap. The aim of this work is to demonstrate the potential of neural networks in creating a safety monitoring system for an automobile repair facility.Materials and Methods. The design materials of the service station at the equipment repair and maintenance center served as basic information. This enterprise was created by specialists of the Department of Operation of Transport Systems and Logistics at the Don State Technical University (DSTU). Risks were classified according to GOST ISO 12 100 and GOST R 58 771. Neural networks were trained using open-source libraries for the Python programming language. The digital monitoring system model with visualization was implemented using the AnyLogic simulation system.Results. The authors of this work trained 20 neural networks and selected five with the lowest error function values (from 74% to 78%). Out of five networks that worked most correctly, one was chosen that predicted the output parameter more accurately — 74%. The neural network with the best performance was a multilayer perceptron with 30 neurons in the input layer, 15 in the hidden layer, and 3 in the output layer. It was used to create a digital twin that warned in real time about potentially dangerous events: the movement of a car, a crane, and the opening of an inspection pit. Additionally, it identified workers without personal protective equipment or access to the work area.Discussion and Conclusion. The use of a digital safety monitoring system model will make it possible to identify high-risk work areas in advance, and reduce accidents and industrial injuries. The introduction of this model in auto repair facilities involves the installation of sensors and warning systems. In the future, we plan to explore the possibility of integrating algorithms with the risk monitoring system to help personnel repair specific types of machines.
Kajian Konsep Fisika Kinematika Gerak pada Hero Khufra (Skill Tyrent’s Revenge) dalam Game Online Mobile Legends Bang Bang
Authors: Agus Anwar  , Munir Rahmawati , Inu Natalisanto Adrianus , Djayus  , Rayzy Perwitasari Sutaji Putri Devina 
Published: February 2025

Dalam permainan online Mobile Legends Bang Bang, terdapat aspek yang berhubungan dengan kinematika gerak, salah satunya adalah durasi kokang skill yang digunakan oleh hero Khufra. Durasi kokang ini berpengaruh pada perbedaan jarak perpindahan yang dicapai oleh Khufra, mulai dari titik awal hingga titik akhir dalam permainan. Oleh karena itu, penting untuk mengkaji konsep kinematika gerak dalam game Mobile Legends Bang Bang, terutama terkait dengan penggunaan skill Tyrent’s Revenge pada hero Khufra. Penelitian ini bertujuan untuk mengidentifikasi konsep kinematika gerak dalam permainan ini serta menganalisis pengaruh durasi kokang hero Khufra terhadap jarak yang ditempuh. Penelitian ini menggunakan data berupa rekaman video penggunaan skill Tyrent’s Revenge pada hero Khufra dalam game Mobile Legends Bang Bang. Video tersebut dianalisis menggunakan software tracker video yang menghasilkan visualisasi grafik maupun data waktu dan jarak perpindahan. Data yang diperoleh selanjutnya digunakan dalam software excel untuk menentukan kurva regresi linier serta nilai R-Squared (R2). Hasil dari penelitian ini menunjukkan bahwa dalam game Mobile Legends Bang Bang kinematika gerak dapat dideskripsikan melalui perpindahan jarak hero Khufra dari titik awal ke titik akhir. Hasil analisis menunjukkan terdapat kurva regresi linier dengan Persamaan garis serta nilai . Nilai mendekati 1 menunjukkan bahwa terdapat pengaruh yang kuat antara waktu kokang terhadap jarak perpindahan hero Khufra.
A Short Tour Through the Translation of the Tourist Text
Authors: Oprea Maria-Otilia 
Published: February 2025

Abstract
Our study focuses on the translation of travel writing, a multi-semiotic genre by excellence, as well as on the specific role of the translator as an intercultural mediator, responsible not only for conveying the intended message faithfully, but especially for the effect the author wants to produce on the target reader. Analysing the translation of the brochure Sibiu - the Treasure from the Foot of the Carpathians from Romanian into French by Audrey Papuchon, we identify the strategy used by the translator in terms of the skopos of the translation and the target readership, the procedures of linguistic transfer, and the techniques she used in order to solve certain difficulties, especially regarding the transposition of culturemes. Therefore, we ascertain that, in addition to translating the text, most attractive and persuasive in itself, the translator has also managed to convey to foreign tourists an important side of the unparalleled image and culture of Romania.
Ordinances of the Sibiu Magistrate from 1564 and their translation into Romanian
Authors: Popa Carmen 
Published: February 2025

Abstract
In the Middle Ages and early modern times, the town registers were the municipal registers in which the various notaries recorded the decisions of the town council regarding the legal and administrative estate of the citizens. I was particularly interested in two documents from the year 1556, which fall outside the usual routine of the book, as they are files regulating the activities of the winegrowers’ association and the activities of the inns. The documents were also discussed from the point of view of their translation into Romanian.
Faces of Trauma in The Life and Times of Michael K
Authors: Frătean Denisa-Maria Bâlc 
Published: February 2025

Abstract
This paper presents the novel The Life and Times of Michael K written by J.M. Coetzee, focusing on the forms of trauma that can be identified in the life of the protagonist: the social trauma, trauma as the sum of interpersonal interactions, and family trauma. Through a philosophical and introspective approach, the writer presents the fact that, in a universe of disillusions, the ego must assume certain forms of resistance, intended to bring initiation and liberation. Silence, metaphysical gardening and a handful of “seeds” are the elements that can transform us, that can bring about the regeneration of the whole society. It takes a life, a journey and a genuine connection with nature to succeed, but it is possible to live in a fragmented universe, full of controversies and vain desires.
Manifestations of Peripheral Realism in Postcommunist European Literature: An Introduction
Authors: Popescu Andreea 
Published: February 2025

Abstract
The aim of this paper is to bring into discussion the concept of peripheral realism as a key concept in analyzing the similarities and differences highlighted in specific literary works, with a particular emphasis on literature originating from Eastern European countries. By employing a specialized approach to the expresions of peripheral realism, the study investigates literary texts produced in peripheral regions with limited global impact. Additionally, detailed attention is given to the influences and consequences of the communist era, which has left its imprint on the respective societies. The central argument of the paper posits that literary works, far from being mere artistic products, substantially reflect geopolitical, ideological and cultural aspects specific to the regions in which they are conceived. Consequently, this research provides a critical and comprehensive perspective on literary interactions within an ever-evolving transnational landscape.
Morphological and Molecular Characterization of a Novel Fungal-feeding Stem Nematode Ditylenchoides agaricivorus n. sp. (Tylenchida: Anguinidae) from Intercepted Samples
Authors: Liang Che-Chang , Chen Pei-Chen 
Published: February 2025

Abstract
A new species of the genus Ditylenchoides, D. agaricivorus n. sp., collected from coconut fiber used as growing media for staghorn ferns and intercepted during import quarantine, is described and illustrated herein based on morphological and molecular studies. The new species is characterized by a body length of 728 (612–846) μm and 641 (511–720) μm in female and male, respectively, delicate stylet 8.0 (7.4–8.4) μm long, six lines in the lateral field, median bulb of esophagus well-developed, muscular with crescentic valve, post-vulval uterine sac well-developed, 36 (22–52) μm long, female tail elongate-conoid with finely rounded terminus. The results of phylogenetic analyses based on sequences of the D2D3 expansion region of 28S rRNA and ITS confirmed the close molecular relationship between D. agaricivorus n. sp., and other Ditylenchoides species such as D. africanus, D. arachis, D. destructor, D. halictus, D. myceliophagus and D. persicus. Ditylenchoides agaricivorus n. sp. was successfully reared on the Rhizoctonia solani and Agaricus biporus. However, D. agaricvorus n. sp. did not reproduce when culturing on Lentinula edodes, Pleurotus erungii, Volcariella volvacea, A. bitorquis, nor on callused carrot disks, and alfalfa seedlings.
Clinical skills learning through medical students’ lenses, during and after a pandemic – a qualitative study
Authors: Elena Marin Laura , Maila Măgdălin Andreea , Băicuș Cristian 
Published: February 2025

Abstract
The Coronavirus disease of 2019 (COVID-19) pandemic caused significant disruptions in medical education, particularly in clinical training, as students were restricted from direct patient interactions. This study explores medical students’ experiences in learning semiology remotely and their perspectives on the role of online education in medical training.
We conducted interviews with 16 medical students in their last year of study. Interviews were audio-recorded and the transcription was verbatim. Thematic analysis was performed.
We identified four main themes: “Acquiring clinical skills during pandemic times”, “Students’ perception about semiology”, “Mapping the role of online learning in medicine”, and “Future perspectives for a better semiology learning”.
Students reported significant anxiety and fear regarding direct patient interactions, alongside a perceived deficiency in clinical skills. They mostly managed to overcome them during the following years. They considered that their teachers offered them as much as possible when it comes to the process of learning, giving the pandemic context. They were able to identify different traits of online learning when it comes to medical subjects except semiology. In some cases, they experienced a lack of understanding from their tutors in regard to their inadequate clinical skills.
Programs should be implemented in order to consolidate COVID-19 students’ clinical knowledge through residency. Online learning cannot be implemented for medical semiology, given the fact that hands-on procedures cannot be substituted.