bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peptide Antigen‐Surfaced TLR9‐Adjuvanting Nanovaccines as a Versatile Therapeutic Modality to Eradicate Acute Myeloid Leukemia
Authors: Sun Yinping , Cui Guanhong , Shi Yan , Xu Bin , Qu Liping , Meng Fenghua , Zhong Zhiyuan 
Published: November 2024

AbstractPeptide antigen vaccines constitute a promising clinical strategy for treating cancer patients. However, their anticancer immune response remains modest because of the suboptimal presentation of peptide antigens and/or insufficient activation of antigen‐presenting cells (APCs). The development of therapeutic vaccines for acute myeloid leukemia (AML) poses an even greater challenge because AML cells disseminate throughout the body. In this study, the peptide antigen‐surfaced TLR9‐adjuvanting nanovaccines (PASTA‐NV), which display multiple Wilm's tumor 1 (WT1) peptides on their surface and encapsulate CpG ODN adjuvants within their watery interior to simultaneously increase antigen presentation and APC activation/proliferation, are reported. Interestingly, systemic administration of PASTA‐NV induces strong cellular and humoral anticancer immune responses in orthotopic murine AML MLL‐AF9 models. When combined with an anti‐CTLA4 antibody, PASTA‐NV achieves complete regression of AML in mouse models and establishes durable anti‐AML immunity, effectively resisting rechallenge with leukemic cells. PASTA‐NV provides a new and general avenue to induce robust and specific anticancer immunity, which has the potential to revive peptide antigen‐based nanovaccines for tumor therapy.
Blade‐Coated Mixed‐Halide Wide‐Bandgap Perovskite Photovoltaics: Progress and Challenges
Authors: Xu Fan , Bao Zheng , Tu Yongguang , Yang Xiaoyu , Ye Fengjun 
Published: November 2024

AbstractWide‐bandgap (WBG) perovskite solar cells (PSC) have been widely applied in tandem photovoltaics (PV) for various scenarios including indoor, building, and underwater PV. However, the current mainstream WBG PSCs are fabricated by spin‐coating, which is inappropriate for scalable production. Blade‐coating has demonstrated great potential to realize commercial PV panel size at low cost, while till present, only a few efforts have been devoted to blade‐coated WBG PSCs, significantly hampering their efficiency evolvements. Herein, state‐of‐the‐art research progress and major challenges of blade‐coated WBG PSCs are reviewed, with their optimization strategies being summarized into four main categories, such as blading parameter, solvent engineering, additive/dopant, and defect passivation. Film homogenization, defect manipulation, optimized blade coating machines, single‐halide three‐dimensional WBG perovskites, and fabrication on the textured substrate are proposed as five promising directions for future investigations on high‐performance blade‐coated WBG PSCs.
Ferrocene Appended Linear Chromophores for Aggregation‐Induced Emission (AIE) and Nonlinear Optics (NLO): Combined Experimental and Theoretical Studies
Authors: Chithra Vadakkalur Sampath , Palanisami Nallasamy 
Published: November 2024

AbstractNew nonlinear optical (NLO)‐active chromophores, featuring phenyl and methoxy phenyl substitutions at the D‐π‐A motif [(Fc‐C(C6H4‐R) = CH‐CH = C(CN)‐C6H4‐Br)] [R = H (1), OCH3 (2)] are synthesized and structurally analyzed. Chromophore 2 crystallized in a triclinic system (P‐1), consistent with DFT‐optimized structures. Non‐covalent interactions in the crystal packing suppress antiparallel alignment, enhancing SHG efficiencies. Molecular electrostatic potential (MEP) maps reveal structure‐property relationship and electronic communication between donor–acceptor moieties. Both chromophores exhibit suppressed emission in solution due to twisted intramolecular charge transfer (TICT) facilitated by the cyano vinylene group. However, Upon aggregation‐induced emission in a THF/H2O mixture, fluorescence significantly increases, attributed to restricted intramolecular rotation (RIR). Second Harmonic Generation (SHG) efficiencies, measured using the Kurtz–Perry powder technique with potassium dihydrogen phosphate (KDP) as a reference, show chromophore 2 is 1.1 times higher efficiency than chromophore 1. Density functional theory (DFT) derived hyperpolarizability values follow this trend, with chromophore 2 (β0 = 40.39 × 10−30 esu in B3LYP functional) surpassing chromophore 1. DFT and time‐dependent density functional theory (TD‐DFT) calculations employing B3LYP, CAM‐B3LYP, and LC‐BLYP functionals determined second‐order nonlinear optical parameters, B3LYP and CAM‐B3LYP produced values with minimal differences and a close correlation with the experimental results.
A Physics‐Driven GraphSAGE Method for Physical Field Simulations Described by Partial Differential Equations
Authors: Hu Hang , Wu Sidi , Cai Guoxiong , Liu Na 
Published: November 2024

AbstractPhysics‐informed neural networks (PINNs) have successfully addressed various computational physics problems based on partial differential equations (PDEs). However, while tackling issues related to irregularities like singularities and oscillations, trained solutions usually suffer low accuracy. In addition, most current works only offer the trained solution for predetermined input parameters. If any change occurs in input parameters, transfer learning or retraining is required, and traditional numerical techniques also need recomputation. In this work, a physics‐driven GraphSAGE approach (PD‐GraphSAGE) based on the Galerkin method and piecewise polynomial nodal basis functions is presented to solve computational problems governed by irregular PDEs and to develop parametric PDE surrogate models. This approach employs graph representations of physical domains, thereby reducing the demands for evaluated points due to local refinement. A distance‐related edge feature and a feature mapping strategy are devised to help training and convergence for singularity and oscillation situations, respectively. The merits of the proposed method are demonstrated through a couple of cases. Moreover, the robust PDE surrogate model for heat conduction problems parameterized by the Gaussian random field source is successfully established, which not only provides the solution accurately but is several times faster than the finite element method in the experiments.
De Novo Balanced Translocations Disrupting the FBN1 Gene Diagnosed by Genome Sequencing: An Uncommon Cause of Marfan Syndrome Modifying Genetic Counseling
Authors: Racine C. , Callier P. , Touraine R. , Vitobello A. , Hanna N. , Arnaud P. , Jondeau G. , Boileau C. , Thauvin‐Robinet C. , Creveaux I. , Gatinois V. , Willems M. , Faivre L. 
Published: November 2024

ABSTRACTMarfan syndrome (MFS) is a well‐characterized rare genetic connective tissue disorder. The features of MFS are primarily skeletal, ocular, and cardiovascular and are mainly caused by single‐nucleotide variants (SNVs) in the FBN1 gene (MIM#134797) located on chromosome 15q21.1. We describe two patients, a 26‐year‐old male and a 10‐year‐old female from unrelated distinct families, with clinically diagnosed sporadic MFS. After years of unsuccessful molecular diagnosis for genetic counseling purposes, genome sequencing was performed and revealed a balanced translocation in both patients: de novo t(9;15)(p13.3;q21.1) translocation in the male patient, and de novo t(15;16)(q21.1;p13.13) translocation in the female patient, respectively, disrupting intron 40 and 45 of FBN1. The other breakpoints were not clinically relevant. These translocations were confirmed by specific fluorescence in situ hybridization probes and conventional karyotyping. In the literature, only one family has been described, leading to four cases of MFS caused by balanced translocations. Genetic counseling for balanced translocations differs from SNVs and even interstitial deletions since it is not restricted to MFS recurrence, but also involves the risk of unbalanced gametes, leading to miscarriage or unbalanced progeny. In case of clinical certainty, MFS patients should be screened for balanced translocations to ensure appropriate genetic counseling.
Traumatic neuroma of the medial antebrachial cutaneous nerve treated by targeted muscle reinnervation using the epitrochleoanconeus muscle
Authors: van Opijnen Mark P. , Wesstein Michel , de Ruiter Godard C. W. 
Published: November 2024

Key Clinical MessageThis case shows the feasibility of targeted muscle reinnervation (TMR) in a patient with a traumatic neuroma of the medial antebrachial cutaneous nerve (MABCN). TMR was performed by connecting the proximal stump of the MABCN to the branch innervating the accessory epitrochleoanconeus muscle. Postoperatively, the patient reported significantly less pain.
Neuroendocrine Neoplasms of the Breast: Current Insights and Future Directions
Authors: Jiang Lei , Pan Xinyuan , Lang Zhiqiang 
Published: November 2024

ABSTRACTBackgroundThe breast neuroendocrine neoplasms (NENs) represent a heterogeneous group of tumors and account for less than 1% of all NENs. The 5th edition of the WHO Classification of Breast Tumors in 2019 introduced a more stringent definition for breast NENs including neuroendocrine tumors (NETs) (G1, G2) and neuroendocrine carcinomas (NECs) (small cell carcinoma, large cell neuroendocrine carcinoma). While the diagnostic criteria and treatment of breast NENs still have some unsolved issues.ObjectiveWe aim to discuss the diagnosis, treatment progress, existing problems, and future development direction of breast NENs.MethodsWe provide a comprehensive review and evaluation of the diagnostic criteria, pathological features, utilization of immunohistochemical markers, molecular characteristics, pathogenesis, clinical significance, treatment options for breast NENs.Results(1) Under the new definition, "pure" breast NENs are extremely rare. (2) Breast NETs are graded according to Nottingham grading System. Grading criteria utilized in other systems for NENs, such as mitotic count, ki67 proliferation index, and necrosis, have not been applied to breast NENs. (3) The WHO has not yet acknowledged the existence of NET G3 clearly. (4) The expression of NE markers may differ in breast NECs. (5) The treatment of breast NENs is still based on IBCs‐NST, and without any difference from invasive carcinoma with NE features. (6) The prognosis of breast NENs remains unclear, while the prognosis for NECs is significantly poorer than invasive breast carcinomas of no special type (IBCs‐NST) has been confirmed.ConclusionStrict adherence to criteria is the key to correctly diagnose breast NENs with the exclusion of metastasis from other sites. Further exploration is required to determine the tissue origin of breast NENs and understand the pathogenesis. Efforts are still needed to establish unified diagnostic criteria and a unique diagnosis and treatment consensus for breast NENs.
Governing for the green: How European board attributes are driving environmental innovation
Authors: Dwekat Aladdin , Abu Alia Muiz , Abdeljawad Islam , Meqbel Rasmi 
Published: November 2024

AbstractThis study examines the impact of corporate board attributes, namely, gender diversity, independence, size, tenure, and CEO duality, on environmental innovation (EI). The study utilised a large dataset of 13,278 firm‐year observations belonging to companies from 24 European countries and covered the period 2010–2021. Drawing from the agency and stakeholder theories, we find that all attributes addressed in this study have a positive impact on EI. These findings enhance our understanding of how businesses manage EI in the real world. Strategic focus is essential for achieving environmental sustainability and fostering innovation in business processes. This study expands our understanding of the role of diverse, long‐term, and independent board structures in fostering EI. We can use the insightful results it provides to plan future corporate strategies and policies.
The influence of NGO‐corporate relationship on environmental disclosure: Evidence from the fashion industry
Authors: Crapa Giuseppe , Roma Paolo , Bruccoleri Manfredi 
Published: November 2024

AbstractMost NGO‐corporate relationships have been founded on conflict. However, this pattern has started to change with the emergence of more collaborative (dialog‐based) approaches. Academic inquiry into how NGOs influence corporate policies related to sustainable development is a novel field of investigation. This article aims to identify the potential role of conflictual versus collaborative relationships between NGOs and companies in influencing the quality of the environmental disclosure (ED). We also investigate how NGOs may unintentionally lead companies to adopt greenwashing practices. In this article, we derive five propositions by studying the relationships between Greenpeace and 24 firms operating in the fashion industry through a qualitative longitudinal analysis. We gathered data through three semi‐structured interviews with the Greenpeace Global Corporate Leader of the Detox Campaign and content analysis of corporate communication documents. Our findings suggest that company behavior toward ED and the odds of greenwashing practices are affected by type of relationship established with NGOs. Specifically, if the NGO‐corporate relationship is conflictual, companies tend to achieve higher ED quality in the short and intermediate terms. Vice versa, more collaborative (dialog‐based) relationships result in initially low ED quality. However, in the long run, under both types of relationship the quality of ED settles at a medium level. Moreover, NGOs' communication, activism intensity, and pressure constitute powerful means of persuasion and contribute to increasing a campaign engagement rate. However, too much pressure may create a fertile ground for greenwashing, and so may an everlasting conflictual relationship between NGO and companies.
The Impact of Preoperative Facial Nerve Weakness and Facial Nerve Outcomes in the Management of Patients With Parotid Metastases of Cutaneous Squamous Cell Carcinoma
Authors: Lin Vivian , Zhang Michael , Gupta Ruta , Elliott Michael S. , Clark Jonathan R. , Wykes James J. , Ch'ng Sydney , Shannon Kerwin F. , Palme Carsten E. , Low Tsu‐Hui 
Published: November 2024

ABSTRACTBackgroundCutaneous squamous cell carcinomas (cSCC) metastasizing to the parotid gland can cause facial nerve (FN) dysfunction secondary to direct invasion, perineural spread, or surgical ablation. This study aims to characterize the prevalence of preoperative FN involvement in metastatic cSCC to the parotid and identify risk factors resulting in FN sacrifice.MethodsPatients with parotid metastases from cSCC, treated surgically with parotidectomy with curative intent were identified through a retrospective cohort analysis of a prospectively maintained Sydney Head and Neck database from 1992 to 2021.ResultsOf 408 patients identified, 39 (10%) were found to have preoperative FN weakness, of which 41% underwent concurrent temporal bone resection compared to 9.1% for the overall cohort. All patients with preoperative FN weakness underwent FN sacrifice. FN sacrifice occurred in n = 145 (36%), of which 88 (61%) required sacrifice of a trunk or division. The 5‐year disease free survival and disease specific survival was worse for patients requiring sacrifice of the FN trunk compared to no sacrifice, however there was no difference in survival for patients requiring sacrifice of the FN division or branch. We found those with > 23.5 mm parotid deposits had an odds ratio of 9.9 for FN sacrifice (95% CI 3.0–32.8, p < 0.001).ConclusionsPreoperative FN weakness was present in 10% of patients and 36% had some part of the FN sacrificed. There was no significant difference in outcomes for patients with and without preoperative FN weakness. Patients who undergo sacrifice of the FN trunk have worse survival compared to those not requiring FN sacrifice, however similar outcomes were observed in those requiring lessor degrees of FN sacrifice. The likelihood FN sacrifice rises with increasing parotid deposit size.
Impact of Digital Technology on Traditional Banking: A Case From the Credit Market in the European Union
Authors: Kouretas Georgios P. , Pawłowska Małgorzata 
Published: November 2024

ABSTRACTThe aim of this study is to investigate whether digital technologies affect the credit market in the European Union (EU). The impact of digital technology on three types of bank loans (residential mortgage loans, consumer loans and corporate loans) is analysed separately for two groups of EU countries: Central and Eastern Europe and Western Europe. A dynamic panel regression model is employed based on yearly data on the individual bank level. The sample panel data cover the period 2010–2019. The results show that digital technology affects the growth of loans for households, mortgages and consumer loans. We also find heterogeneity between the Central and Eastern European and Western European banking sectors. Furthermore, the impact of digital technology on bank loan development is significantly stronger in foreign banks. Finally, the findings confirm the dominant role of digital technologies in loans for households during the analysed period. This is the first comprehensive study on the determinants of different loan types in the context of digital technology use in the EU.
Can the Original Use of an Employee Handbook Inform Present Day and Future Employee Relations?
Authors: Ritter Beth M. 
Published: November 2024

ABSTRACTThis review analyzed the original intention of employee handbooks and the evolution of handbooks over multiple decades to determine if there was valuable learning for today's postindustrial organizations. Four different employee relationship themes emerged from the review and are considered from an evidence‐based research perspective. Actual handbook observations, either in text or numerical summary, are shared for perspective. The review findings offer firms considerations for current‐day approaches to demonstrate employer commitments and organizational support for employees. The review identified four themes that aligned with organization support theory. Perceived organizational support has been shown to create positive employee outcomes for organizations. Demonstration of the themes, expectation setting via culture and values, psychological contracting via future opportunity sharing, inviting employee voice via decision making and problem resolution processes, and practicing organizational justice via consistency to policies, all offer the possibility for enhanced perceptions of organization support by employees. Positive outcomes of greater employee retention, presenteeism, and productivity in organizations can be realized by firms that can learn from the themes found in the review and adjust to capture the opportunity.
Observation and Manipulation of Self‐Chaos in Disordered Optical System
Authors: Li Haosen , Lv Jialiang , Li Hongtao , Ren Hongda , Yang Yaozhong , Xu Guanghui , Yang Lixia , Yu Qi , Wang Zhiqiang , Hu Zhijia , Yu Benli , Lu Liang 
Published: November 2024

AbstractOptical chaos is an attractive topic due to its unique dynamics and has been widely investigated in external‐cavity lasers. While chaotic behavior is hindered by undesired periodicity from external feedback. Although a self‐chaotic micro‐laser based on nonlinear interaction of internal modes can eliminate the periodicity, the inevitable characteristic frequency related to well‐defined cavity limits the improvement of chaotic performance. By virtue of the inherent randomness, disordered optical system can naturally avoid characteristic frequency and is deemed an ideal platform for generating self‐chaos. Here, the dynamical evolution process of self‐chaos in disordered optical system is observed, and self‐chaotic behavior can be flexibly manipulated by altering the interaction strength among random modes. Simultaneously, by adopting Erbium‐Raman hybrid gain, chaotic bandwidth can be synergistically enhanced to 38 GHz, which is successfully employed for higher‐speed true random bits generation and a scheme of local information encryption with higher‐quality. This work paves the way for investigating complex chaotic dynamics in disordered systems and showcases great potentialities within information security applications.
Leveraging Nanoengineered Microneedle‐Augmented Drug Delivery in Oncological Intervention
Authors: Singh Mansi , Shukla Rahul 
Published: November 2024

AbstractThe landscape of chemotherapy for cancer is experiencing a dramatic transition with the integration of sophisticated drug delivery methods, especially nanoengineered microneedles. Percutaneous vaccination is regarded the optimum therapeutic approach due to the high amount of immune cell accumulation and the rich capillary lymphatic system in the dermis. The curative impact of Microneedles‐based cancer vaccines is suboptimal due to the complicated mix of tumor, host, and environmental variables, as well as the vaccine's restricted loading capacity. As a result, additional enhancements are still needed to accelerate their clinical translation. This article offers a meticulous analysis of the avant‐garde strategies harnessed to augment drug delivery via microneedle. Various tactics, such as tailored nanoparticle carriers, functionalized microneedle arrays, and real‐time monitoring system, work together to improve therapeutic efficacy and prevent off‐target effects. By integrating recent advancement and delineating future trajectories, this article gives an in‐depth analysis of how nanoengineered microneedle‐augmented technologies have the potential to change the face of cancer therapy, heralding in a new era of precision medicine and better outcomes.
A Boat‐Paddle‐Like Molecule Binder with Twining‐Blocked and Ultrafast Self‐Healing Functionalities for Stable Silicon Anodes
Authors: Dong Yueyao , Dong Liwei , Li Yaqiang , Xu Feiyu , Yue Junpei , Zhao Yu‐Ming , Lu Zhuo‐Ya , Niu Min , Lei Zuotao , Yang Chunhui , Liang Jia‐Yan , Guo Yu‐Guo 
Published: November 2024

AbstractSelf‐healing binder is a prospective and efficient strategy to alleviate volume expansion of silicon (Si) anodes. However, excellent mechanical strength and healing ability tend to be mutually exclusive, due to enhanced tensile stress limit by twining polymer chains, while inhibiting polymer diffusion rate and inducing healing failure by blocked chains. Herein, inspired by the planning course of boat and paddles, a novel self‐healing binder (PVA‐4FBA‐PEI) is designed and synthesized with mobile parallel structure and twining‐blocked characteristics. The boat‐like intermediate (4‐formylphenyl) boronic acid (4FBA) blocks entanglement of poly(vinyl alcohol) (PVA) and poly(ethyleneimine) (PEI) chains, where two parallel chains as paddles can simultaneously form to ensure rapid diffusion of chains during bond breakage. Remarkably, it endows dynamic synergistic covalent bonds via C═N and B─O─C junctions within 4FBA, providing the binder with an ultrafast self‐healing time of merely 2 min. Moreover, the binder integrates superior plasticity and flexibility of each chain, showing a high tensile strength (14.4 MPa) and stretchability (1163%) among state‐of‐the‐art polymer binders, thus significantly improving structural integrity and electrochemical stability of Si anode during cycling. This work proposes a dynamic reversible structure via figurative molecular coordination, affording a rational viewpoint on synergetic functionalities of polymer binders for Si anodes.