bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of serological tests for diagnosis of chronic pulmonary aspergillosis: a systematic review and meta-analysis
Authors: Chaves Cláudia Elizabeth Volpe , do Valle Leone de Oliveira Sandra Maria , Venturini James , Grande Antonio Jose , Sylvestre Tatiane Fernanda , Mendes Rinaldo Poncio , Paniago Anamaria Mello Miranda 
Published: September 2019

AbstractChronic pulmonary aspergillosis (CPA) is a disease that benefits from cavities as after-effects of tuberculosis, presenting a high mortality rate. Serological tests like double agar gel immunodiffusion test (DID) or the counterimmunoelectrophoresis (CIE) test have been routinely used for CPA diagnosis in the absence of positive cultures; however, they have been replaced by enzyme-linked immunoassay (ELISA), with a variety of methods.This systematic review aims to compare the accuracy of the ELISA test with the reference test (DID and/or CIE) in CPA diagnosis. It was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA).The study was registered in PROSPERO under the registration number CRD42016046057. We searched the electronic databases MEDLINE (PubMed), EMBASE (Elsevier), LILACS (VHL), Cochrane library, and ISI Web of Science. Gray literature was researched in Google Scholars and conference abstracts. We included articles with patients or serum samples from CPA patients who underwent two serological tests: ELISA (index test) and IDD and/or CIE (reference test), using the accuracy of the tests as a result. Original articles were considered without a restriction of date or language. The pooled sensitivity, specificity, and summary receiver operating characteristic curves were estimated.We included 13 studies in the review, but only four studies were included in the meta-analysis. The pooled sensitivities and specificities were 0.93 and 0.97 for the ELISA test. For the reference test (DID and/or CIE), these values were 0.64 and 0.99. Analyses of summary receiver operating characteristic curves yielded 0.99 for ELISA and 0.99 for the reference test (DID and/or CIE). Our meta-analysis suggests that the diagnostic accuracy of ELISA is greater than that of the reference tests (DID and/or CIE) in early detection of CPA.
Third-party prosocial behavior in adult female rats is impaired after perinatal fluoxetine exposure
Authors: Heinla Indrek , Heijkoop Roy , Houwing Danielle J. , Olivier Jocelien D.A. , Snoeren Eelke M.S. 
Published: September 2019

AbstractSSRIs are commonly used to treat pregnant women with depression. However, SSRIs can cross the placenta and affect the development of the fetus. The effects of perinatal SSRI exposure, and especially the effects on social behavior, are still incompletely documented. This study first aims to investigate whether rats show prosocial behavior in the form of consolation behavior. Secondly, it aims to investigate whether perinatal SSRI exposure affects this prosocial behavior. At last, we investigate whether the behavior changed after the rats had been exposed to an additional white-noise stressor.Rat dams received 10 mg/kg/d fluoxetine (FLX) or vehicle (CTR) via oral gavage from gestational day 1 until postnatal day 21. At adulthood, the rat offspring were housed in four cohorts of 4 females and 4 males in a seminatural environment. As prosocial behaviors are more prominent after stressful situations, we investigated the behavioral response of rats immediately after natural aggressive encounters (fights). Additionally, we studied whether a stressful white-noise exposure would alter this response to the aggressive encounters.Our study indicates that CTR-female rats are able to show third party prosocial behavior in response to witnessing aggressive encounters between conspecifics in a seminatural environment. In addition, we showed that perinatal FLX exposure impairs the display of prosocial behavior in female rats. Moreover, we found no signs of prosocial behavior in CTR- and FLX-males after natural aggressive encounters. After white-noise exposure the effects in third party prosocial behavior of CTR-females ceased to exist. We conclude that female rats are able to show prosocial behavior, possibly in the form of consolation behavior. In addition, the negative effects of perinatal fluoxetine exposure on prosocial behavior could provide additional evidence that SSRI treatment during pregnancy could contribute to the risk for social impairments in the offspring.
Impaired liver regeneration and lipid homeostasis in CCl4 treated WDR13 deficient mice
Authors: Mishra Arun Prakash , Siva Archana B , Gurunathan Chandrashekaran , Komala Y , Lakshmi B Jyothi 
Published: September 2019

AbstractBackground and AimWDR13 - a WD repeat protein, is abundant in pancreas, liver, ovary and testis. Absence of this protein in mice has been seen to be associated with pancreatic β-cell proliferation, hyperinsulinemia and age dependent mild obesity. Previously, we have reported that the absence of WDR13 in diabetic Leprdb/db mice helps in amelioration of fatty liver phenotype along with diabetes and systemic inflammation. This intrigued us to study direct liver injury and hepatic regeneration in Wdr13−/0 mice using hepatotoxin CCl4.MethodsMice were injected with CCl4 twice a week for 8 consecutive weeks. Controls were injected with vehicle (olive oil) similarly. After the last injection, mice were given a 10-days of recovery period and then sacrificed for physiological and molecular analyses.ResultsIn the present study we report slower hepatic regeneration in Wdr13−/0 mice as compared to their wild type littermates after CCl4 administration. Interestingly, during the regeneration phase, hepatic hypertriglyceridemia was observed in Wdr13−/0 mice. Further analyses revealed an upregulation of PPAR pathway in the liver of CCl4-administered Wdr13−/0 mice, causing de novo lipogenesis.ConclusionsThe slower hepatic regeneration observed in CCl4 administered Wdr13−/0 mice, may be linked to liver hypertriglyceridemia because of activation of PPAR pathway.
Linker Histone H1 subtypes specifically regulate neutrophil differentiation
Authors: Sollberger Gabriel , Streeck Robert , Caffrey Brian E. , Skoultchi Arthur I. , Zychlinsky Arturo 
Published: September 2019

AbstractNeutrophils are important innate immune cells that tackle invading pathogens with different effector mechanisms. They acquire this antimicrobial potential during their maturation in the bone marrow, where they differentiate from hematopoietic stem cells in a process called granulopoiesis. Mature neutrophils are terminally differentiated and short-lived with a high turnover rate. Here, we show a critical role for linker histone H1 on the differentiation and function of neutrophils using a genome-wide CRISPR/Cas9 screen in the human cell line PLB-985. We systematically disrupted expression of somatic H1 subtypes to show that individual H1 subtypes affect PLB-985 maturation in opposite ways. Importantly, H1 subtypes also affect neutrophil differentiation of murine bone marrow stem cells, demonstrating an unexpected subtype-specific role for H1 in granulopoiesis.
Local network determinants of spontaneously emerging cortical maps
Authors: Fekete Tomer , Omer David B. , Grinvald Amiram , van Leeuwen Cees 
Published: September 2019

ABSTRACTSpontaneously emerging cortical maps related to the functional architecture of visual cortex have been observed initially in anesthetized cats and, subsequently, in monkey, albeit only under certain anesthetic regimes, and not in the awake state. Here we propose a network model that can accommodate these diverse findings. The model identifies two crucial determinants for the emergence of spontaneous map-like activity – local balance between excitatory and inhibitory activity, and the strength of feature-specific synaptic connections (e.g. orientation, ocularity). Our model further shows that dynamically, map-like activity patterns could be triggered either by standing or travelling waves, a mode of operation which is determined by the spatial extent of lateral connections within a given network. Our results suggest that careful pharmacological intervention can unveil the prevalence of maps – recurring spatial patterns of inhomogeneous lateral connectivity - in cortex without the need to explicitly identify area specific optimal features.
Transcriptomic profiling of plaque psoriasis and cutaneous T cell subsets during treatment with secukinumab
Authors: Liu Jared , Chang Hsin-Wen , Beck Kristen M. , Sekhon Sahil , Schmidt Timothy H. , Yan Di , Huang Zhi-Ming , Yang Eric J. , Sanchez Isabelle M. , Nakamura Mio , Bhattarai Shrishti , Thibodeaux Quinn , Ahn Richard , Bhutani Tina , Rosenblum Michael D. , Liao Wilson 
Published: September 2019

AbstractThe IL17A inhibitor secukinumab is efficacious for the treatment of psoriasis. In order to define its mechanism of action, it is important to understand its impact on psoriatic whole skin tissue as well as specific skin-resident immune cell populations such as T lymphocytes. In this study, we treated 15 moderate-to-severe plaque psoriasis patients with secukinumab and characterized the longitudinal transcriptomic changes of whole lesional skin tissue and cutaneous CD4+ T effector cells (Teffs), CD4+ T regulatory cells (Tregs), and CD8+ T effector cells during 12 weeks of treatment. Secukinumab was clinically effective, with 100%, 47%, and 27% of patients in the study achieving PASI75, PASI90, and PASI100 by week 12, respectively. At baseline prior to treatment, we observed that IL17A overexpression predominates in psoriatic CD8+ T cells rather than Teffs, supporting the importance of IL-17-secreting CD8+ T cells (Tc17) compared to IL-17-secreting CD4+ T cells (Th17) cells in the pathogenesis of psoriasis. Although secukinumab targets only IL17A, we observed rapid reduction of IL17A, IL17F, IL23A, IL23R, and IFNG expression in lesional skin as soon as 2 weeks after initiation of treatment and normalization of expression by week 12. Secukinumab treatment resulted in resolution of 89-97% of psoriasis-associated expression differences in both bulk tissue and T cell subsets by week 12 of treatment. Overall, secukinumab appears to rapidly reverse many of the molecular hallmarks of psoriasis.
A glycogenin homolog controls Toxoplasma gondii growth via glycosylation of an E3 ubiquitin ligase
Authors: Mandalasi Msano , Kim Hyun W. , Thieker David , Osman Sheikh M. , Gas-Pascual Elisabet , Rahman Kazi , Zhao Peng , Daniel Nitin G. , van der Wel Hanke , Ichikawa H. Travis , Glushka John N. , Wells Lance , Woods Robert J. , Wood Zachary A. , West Christopher M. 
Published: September 2019

ABSTRACTSkp1, a subunit of E3 Skp1/Cullin-1/F-box protein ubiquitin ligases, is uniquely modified in protists by an O2-dependent prolyl hydroxylase that generates the attachment site for a defined pentasaccharide. Previous studies demonstrated the importance of the core glycan for growth of the parasite Toxoplasma gondii in fibroblasts, but the significance of the non-reducing terminal sugar was unknown. Here, we find that a homolog of glycogenin, an enzyme that can initiate and prime glycogen synthesis in yeast and animals, is required to catalyze the addition of an α-galactose in 3-linkage to the subterminal glucose to complete pentasaccharide assembly in cells. A strong selectivity of the enzyme (Gat1) for Skp1 in extracts is consistent with other evidence that Skp1 is the sole target of the glycosyltransferase pathway. gat1-disruption results in slow growth attesting to the importance of the terminal sugar. Molecular dynamics simulations provide an explanation for this finding and confirm the potential of the full glycan to control Skp1 organization as in the amoebozoan Dictyostelium despite the different terminal disaccharide assembled by different glycosyltransferases. Though Gat1 also exhibits low α-glucosyltransferase activity like glycogenin, autoglycosylation is not detected and gat1-disruption reveals no effect on starch accumulation. A crystal structure of the ortholog from the crop pathogen Pythium ultimum explains the distinct substrate preference and regiospecificity relative to glycogenin. A phylogenetic analysis suggests that Gat1 is related to the evolutionary progenitor of glycogenin, and acquired a role in glycogen formation following the ancestral disappearance of the underlying Skp1 glycosyltransferase prior to amoebozoan emergence.
Variability aware FinFET SRAM cell with improved stability and power for low power applications
Authors: Birla Shilpi 
Published: September 2019

Purpose
Major area of a die is consumed in memory components. Almost 60-70% of chip area is being consumed by “Memory Circuits”. The dominant memory in this market is SRAM, even though the SRAM size is larger than embedded DRAM, as SRAM does not have yield issues and the cost is not high as compared to DRAM. At the same time, the other attractive feature for the SRAM is speed, and it can be used for low power applications. CMOS SRAM is the crucial component in microprocessor chips and applications, and as the said major portion of the area is dedicated to SRAM arrays, CMOS SRAM is considered to be the stack holders in the memory market. Because of the scaling feature of CMOS, SRAM had its hold in the market over the past few decades. In recent years, the limitations of the CMOS scaling have raised so many issues like short channel effects, threshold voltage variations. The increased thrust for alternative devices leads to FinFET. FinFET is emerging as one of the suitable alternatives for CMOS and in the region of memory circuits.

Design/methodology/approach
In this paper, a new 11 T SRAM cell using FinFET technology has been proposed, the basic component of the cell is the 6 T SRAM cell with 4 NMOS access transistors to improve the stability and also makes it a dual port memory cell. The proposed cell uses a header scheme in which one extra PMOS transistor is used which is biased at different voltages to improve the read and write stability thus, helps in reducing the leakage power and active power.

Findings
The cell shows improvement in RSNM (read static noise margin) with LP8T by 2.39× at sub-threshold voltage 2.68× with D6T SRAM cell, 5.5× with TG8T. The WSNM (write static noise margin) and HM (hold margin) of the SRAM cell at 0.9 V is 306 mV and 384  mV. It shows improvement at sub-threshold operation also. The leakage power is reduced by 0.125× with LP8T, 0.022× with D6T SRAM cell, TG8T and SE8T. The impact of process variation on cell stability is also discussed.

Research limitations/implications
The FinFet has been used in place of CMOS even though the FinFet has been not been a matured technology; therefore, pdk files have been used.

Practical implications
SRAM cell has been designed which has good stability and reduced leakage by which we can make an array and which can be used as SRAM array.

Social implications
The cell can be used for SRAM memory for low power consumptions.

Originality/value
The work has been done by implementing various leakage techniques to design a stable and improved SRAM cell. The advantage of this work is that the cell has been working for low voltage without degrading the stability factor.
Study on curved surface design of sliding pair based on stepped topography model
Authors: Wu Zhenpeng , Nguyen Vanliem , Zhang Zhihong , Zeng Liangcai 
Published: September 2019

Purpose
The stepped topography of the friction pairs mainly causes the fluid film thickness to change in the direction of motion. In this region, there have very few topographical design methods for continuous or non-linear distribution of the fluid film. The purpose of this study is to analyze the effect of the curved surface on the performance of the liquid film.

Design/methodology/approach
First, a numerical simulation is used to solve the optimal bearing capacity and friction coefficient of the liquid film under the condition of the minimum film thickness. Then, the curved surface described by the sinusoidal curve equation is applied in the transitional region of maximum and minimum film thickness. The bearing capacity and the friction coefficient of the liquid film are respectively simulated and compared in the same condition of the minimum film thickness.

Findings
The research results show that the liquid film using the curved surface transition model, the optimal bearing capacity is significantly increased by 32 per cent while the optimal friction coefficient is clearly reduced by 38 per cent in comparison with using stepped surface model.

Originality/value
The friction pair with curved transition enables better lubrication performance of the liquid film and better adaptability under unstable conditions.
Effect of percolation on hydrodynamic lubrication of rough bilayer porous bearing with circular contact
Authors: Zhang Guotao , Tong Baohong , Yang Shubao , Shi Liping , Yin Yanguo 
Published: September 2019

Purpose
The purpose of this paper was to study the hydrodynamic lubrication of rough bilayer porous bearing to reveal the effect of percolation.

Design/methodology/approach
The seepage lubrication model of the circular bilayer porous bearing was established in polar coordinates. The digital filtering technique and Darcy’s law were used to simulate the rough surface and the percolation characteristic of the oil bearing, respectively. The influence of the structural parameters on the lubrication performance was analyzed.

Findings
Compared with the ordinary monolayer oil bearing with high porosity, the bilayer bearing can reduce the whole porosity, prevent oil infiltrating into the porous medium and have better lubrication performance. The lubrication performance of bilayer oil bearing is better than that of the single-layer oil bearing which has a higher porosity. With increasing root-mean-square roughness or decreasing surface porosity, the lubrication performance of the bilayer bearing improves. The lower the porosity of the surface layer, the better the lubrication performance.

Originality/value
This research provides a theoretical basis for clarifying the lubrication mechanism and influence the mechanism of the bilayer oil bearing.
Effects of privacy policy visualization on users’ information privacy awareness level
Authors: Soumelidou Aikaterini , Tsohou Aggeliki 
Published: September 2019

PurposeThe purpose of this paper is to propose visualization techniques as a new representation for privacy policies instead of traditional textual representation and to examine empirically their effects on users’ information privacy awareness level.Design/methodology/approachThe authors selected as a case the privacy policy of Instagram and conducted two empirical investigations, each one with three interventions and each representing a different version of the Instagram privacy policy to users. Through a pre- and a post-questionnaire, the authors examined the effects that each representation technique had on the users’ privacy awareness level.FindingsThe paper finds that visualized privacy policies lead to higher privacy awareness levels than conventional textual ones, especially when icons are included.Research limitations/implicationsThe authors implemented two new representation techniques offering beneficial guidelines for designing more attractive privacy policy representations. However, the samples are rather limited for generalization to the wide population; nonetheless, they are significant to demonstrate the effect of visualized techniques. The findings might also be subject to bias (e.g. brand bias), although the authors took necessary methodological actions to prevent bias.Practical implicationsThe results and the methodology of the paper could guide practitioners for the representation of a privacy policy, given that the authors provide systematic and concrete steps.Originality/valueThis paper examines the value of privacy policy visualization as a new approach for enabling user privacy awareness, as well as implements two visualization techniques for a given privacy policy. The paper and its findings should be useful for researchers, as well as for practitioners.
Investigation of crack in beams using anti-resonance technique and FEA approach
Authors: Bhaurkar Vyankatesh Prabhakar , Thakur Ajaykumar Gulabsing 
Published: September 2019

Purpose
In the case of machines, structures and assemblies, the crack generation and propagation is becoming a great concern, especially in airplane wings, turbine blades and such other applications. This is because these parts are very large in size and the crack size is very small, i.e. in microns. Hence, there is an important need to locate the crack and to find its severity before it starts to propagate and also to detect these parameters by on-site non-destructive testing methods. This paper aims to develop and test the methodology to locate an unknown single open crack in steel cantilever beam along with its severity.

Design/methodology/approach
This study covers analytical, numerical and experimental analysis for healthy and cracked beams. Vibration-based approach and finite element analysis (FEA) approach is used for analytical and numerical study respectively. Own designed and dedicated experimental set-up is used for testing purpose along with fast fourier transform analyzer. An anti-resonance technique is used to locate and to find the severity of unknown crack. The statistical approach helps to validate the results.

Findings
The comparison of the natural frequency of healthy and cracked steel cantilever beam shows that the crack in the beam reduces its natural frequency. The accuracy of results is achieved by finding actual density and Young's modulus of steel specimen under consideration. It is helpful to verify the health of the non-cracked beam by applying dye testing. The study of natural frequency and anti-resonance gives the location of crack and its depth also. The FEA approach proved to be an important tool for numerical analysis of cracked beam.

Research limitations/implications
The research is limited to steel material and surface cracks only.

Practical implications
Practically, this study highlights how to locate a surface crack in steel beam along with its depth, i.e. severity with great accuracy. Identification of the factors such as location and depth of a crack provide the severity of damage in airplane wings, turbine blades, bridges and many more, and thereby, it helps in safety at working vicinity.

Social implications
The identification and solutions of current research helps to predict the operational life of machine elements such as airplane wings, turbine blades, bridges and many more, and thereby, it helps in the safety of people in working vicinity of such structures.

Originality/value
The work presented, is based on original research and experimentation. This work is valued contribution in the field of methodologies applied for fault detection in structures and also determining its correctness by numerical and experimental work.