bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modification of Epoxy Resin with a Phosphorus, Nitrogen, and Fluorine Containing Polymer to Improve the Flame Retardant and Hydrophobic Properties
Authors: Chen Ting , Peng Chaohua , Liu Cheng , Yuan Conghui , Hong Jing , Chen Guorong , Xu Yiting , Dai Lizong 
Published: November 2018

AbstractTargeting high‐effective modification of flame retardant epoxy resin, elements including phosphorus, nitrogen, and fluorine are simultaneously incorporated into a polymer named as PFNP. A certain amount of amino groups are preserved on PFNP chains to participate in the curing of epoxy resin. The reactive groups and segments contain 9,10‐dihydro‐oxa‐10‐phosphaphenanthrene‐10‐oxide (DOPO) endowed PFNP with good compatibility in epoxy resin. The proper addition of PFNP improves the mechanical property and Tg values of epoxy resins. The limiting oxygen index values of EP/PFNP increases while the peak heat release rate, heat release capacity, and total heat release values reduce after introduction of PFNP. Samples with contents of PFNP higher than 5 wt% reach UL‐94 V‐0 rating without dripping. Notably, the migration effect of trifluoromethyl (CF3) groups not only increases the water contact angles, but also reduces the dielectric constants of epoxy resins.
pH and Thermo Dual‐Responsive Fluorescent Hydrogel Actuator
Authors: Wu Bao‐Yi , Le Xiao‐Xia , Jian Yu‐Kun , Lu Wei , Yang Zhen‐Yu , Zheng Zhi‐Kun , Théato Patrick , Zhang Jia‐Wei , Zhang Afang , Chen Tao 
Published: November 2018

AbstractAs one of the most important smart materials, fluorescent hydrogel actuators can produce both color and shape changes under external stimuli. In the present work, an effective approach to develop a novel fluorescent hydrogel actuator with pH and thermo dual responsiveness is proposed. Through incorporating pH‐responsive perylene tetracarboxylic acid (PTCA), which is a typical fluorescent moiety with aggregation‐caused quenching (ACQ) effect, into an anisotropic poly(N‐isopropylacrylamide)–polyacrylamide (PNIPAm‐PAAm) structure, the obtained hydrogel exhibits stable thermoresponsive shape deformation and switchable fluorescence performance upon a pH trigger. Therefore, fluorescence‐quenching‐based and actuation‐based information can be revealed when exposed to UV light and immersed into warm water, respectively. Moreover, the thermoresponsive actuating behavior can be applied to further hide the fluorescence‐quenching‐based images. The present work may provide new insights into the design and preparation of novel stimuli‐responsive hydrogel actuators.
Diverse serotonin actions of vilazodone reduce l‐3,4‐dihidroxyphenylalanine–induced dyskinesia in hemi‐parkinsonian rats
Authors: Meadows Samantha M. , Conti Melissa M. , Gross Libby , Chambers Nicole E. , Avnor Yarden , Ostock Corinne Y. , Lanza Kathryn , Bishop Christopher 
Published: November 2018

ABSTRACT
Background: The serotonergic system is a well‐established modulator of l‐dopa‐induced dyskinesia. To date, targeting serotonin transporters or serotonin receptor subtype 1A (5‐HT1A) reduces l‐dopa‐induced dyskinesia in animal models; however, these strategies have failed to translate clinically. Ideally, a compound acting at both known antidyskinetic sites could optimize serotonin‐mediated approaches. Vilazodone is a selective serotonin reuptake inhibitor and a partial 5‐HT1A agonist approved by the U.S. Food and Drug Administration, situating Vilazodone in a unique position to reduce l‐dopa‐induced dyskinesia without compromising l‐dopa‐mediated motor improvements.
Objectives: The goal of the present study was to characterize Vilazodone's effects on l‐dopa‐induced behaviors, neurochemistry and gene expression in unilateral 6‐hydroxydopamine‐lesioned hemi‐parkinsonian rats.
Methods: In experiments 1 and 2, l‐dopa‐naïve and l‐dopa‐primed animals were coadministered Vilazodone and l‐dopa daily for 3 weeks to model subchronic use, and behavioral, neurochemical, and messenger RNA (mRNA) expression changes were measured. In experiment 3, dyskinetic behavior was assessed following 5‐HT1A or serotonin receptor subtype 1B blockade prior to Vilazodone–l‐dopa coadministration.
Results: Vilazodone significantly suppressed developing and established l‐dopa‐induced dyskinesia without compromising the promotor effects of l‐dopa therapy. In the dopamine‐depleted striatum, Vilazodone–l‐dopa cotreatment increased dopamine content, suggesting a normalization of dopamine kinetics in dyskinetic brain, and reduced l‐dopa‐induced c‐Fos and preprodynorphin mRNA overexpression, indicative of attenuated dopamine D1 receptor‐mediated direct pathway overactivity. Only 5‐HT1A antagonism partially attenuated Vilazodone's antidyskinetic efficacy, suggesting both serotonin transporter‐dependent effects and 5‐HT1A receptors in Vilazodone's actions.
Conclusions: Our findings show Vilazodone has a serotonin‐dependent effect on rodent l‐dopa‐induced dyskinesia and implicate the potential for repositioning Vilazodone against l‐dopa‐induced dyskinesia development and expression in Parkinson's disease patients. © 2018 International Parkinson and Movement Disorder Society
Intact automatic motor inhibition in patients with tourette syndrome
Authors: Stenner Max‐Philipp , Baumgaertel Charlotte , Heinze Hans‐Jochen , Ganos Christos , Müller‐Vahl Kirsten R. 
Published: November 2018

Abstract
Background: Behavioral disinhibition has been proposed as a key mechanism in Tourette syndrome. Yet classic inhibition tasks have yielded inconsistent results, likely reflecting interference by strategies compensating for tic release.
Methods: We examined a core inhibitory function that is immune to such interference because it suppresses movements automatically. We measured automatic motor inhibition behaviorally in 21 adults with Tourette syndrome and 21 healthy controls via the negative compatibility effect. When a motor response is activated, for example, by a subliminal prime stimulus, but execution is delayed, activation turns into inhibition, increasing reaction time and error. Diminished automatic inhibition could underlie tic release.
Results: Both controls and patients showed strong automatic motor inhibition with no significant group difference. Bayesian statistics, allowing inference on the absence of effects, favored intact inhibition in patients. Our study was well powered.
Conclusions: Automatic motor inhibition in Tourette syndrome is neither impaired nor harnessed by compensation. © 2018 International Parkinson and Movement Disorder Society
Autosomal dominant Marfan syndrome caused by a previously reported recessive FBN1 variant
Authors: Overwater Eline , Efrat Rifka , Barge‐Schaapveld Daniela Q. C. M. , Lakeman Phillis , Weiss Marjan M. , Maugeri Alessandra , van Tintelen J. Peter , Houweling Arjan C. 
Published: November 2018

AbstractBackgroundPathogenic variants in FBN1 cause autosomal dominant Marfan syndrome but can also be found in patients presenting with apparently isolated features of Marfan syndrome. Moreover, several families with autosomal recessive Marfan syndrome caused by pathogenic variants in FBN1 have been described. The aim of this report was to underline the clinical variability that can be associated with the pathogenic variant c.1453C>T, p.(Arg485Cys) in FBN1.MethodsWe provide the clinical details of two autosomal dominant families with this specific FBN1 variant, which was previously associated with autosomal recessive Marfan syndrome.ResultsClinical data of 14 individuals carrying this variant from these two families were collected retrospectively. In both families, the diagnosis of autosomal dominant Marfan syndrome was established based on the characteristics of the variant and the phenotype which includes aortic aneurysms and dissections. Of interest, in one of the families, multiple relatives were diagnosed with early onset abdominal aortic aneurysms.ConclusionIn conclusion, FBN1 variant c.1453C>T, p.(Arg485Cys) is a pathogenic variant that can cause autosomal dominant Marfan syndrome characterized by a high degree of clinical variability and apparently isolated early onset familial abdominal aortic aneurysms.
Assessment of cardiac‐driven liver movements with filtered harmonic phase image representation, optical flow quantification, and motion amplification
Authors: Hahn Stephan , Absil Julie , Debeir Olivier , Metens Thierry 
Published: November 2018

PurposeTo characterize cardiac‐driven liver movements using a harmonic phase image representation (HARP) with an optical flow quantification and motion amplification method. The method was applied to define the cardiac trigger delay providing minimal signal losses in liver DWI images.MethodsThe 16‐s breath‐hold balanced‐SSFP time resolved 20 images/s were acquired at 3T in coronal and sagittal orientations. A peripheral pulse unit signal was recorded. Cardiac‐triggered DWI images were acquired after different peripheral pulse unit delays. A steerable pyramid decomposition with multiple orientations and spatial frequencies was applied. The liver motion field‐map was derived from temporal variations of the HARP representation filtered around the cardiac frequency. Liver displacements were quantified with an optical flow method; moreover the right liver motion was amplified.ResultsThe largest displacements were observed in the left liver (feet‐head:3.70 ± 1.06 mm; anterior–posterior: 2.35 ± 0.51 mm). Displacements were statistically significantly weaker in the middle right liver (0.47 ± 0.11 mm; P = 0.0156). The average error was 0.013 ± 0.022 mm (coronal plane) and 0.021 ± 0.041 mm (sagittal plane). The velocity field demonstrated opposing movements of the right liver extremities during the cardiac cycle. DWI signal loss was minimized in regions and instants of smallest amplitude of both velocity and velocity gradient.ConclusionCardiac‐driven liver movements were quantified with combined cardiac frequency‐filtered HARP and optical flow methods. A motion phase opposition between right liver extremities was demonstrated. Displacement amplitude and velocity were larger in the left liver especially along the vertical direction. Motion amplification visually emphasized cardiac‐driven right liver displacements. The optimal cardiac timing minimizing signal loss in liver DWI images was derived.
Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury
Authors: Kojima Kota , Miyoshi Hiroyuki , Nagoshi Narihito , Kohyama Jun , Itakura Go , Kawabata Soya , Ozaki Masahiro , Iida Tsuyoshi , Sugai Keiko , Ito Shuhei , Fukuzawa Ryuji , Yasutake Kaori , Renault-Mihara Francois , Shibata Shinsuke , Matsumoto Morio , Nakamura Masaya , Okano Hideyuki 
Published: November 2018

AbstractTumorigenesis is an important problem that needs to be addressed in the field of human stem/progenitor cell transplantation for the treatment of subacute spinal cord injury (SCI). When certain “tumorigenic” cell lines are transplanted into the spinal cord of SCI mice model, there is initial improvement of motor function, followed by abrupt deterioration secondary to the effect of tumor growth. A significant proportion of the transplanted cells remains undifferentiated after transplantation and is thought to increase the risk of tumorigenesis. In this study, using lentiviral vectors, we introduced the herpes simplex virus type 1 thymidine kinase (HSVtk) gene into a human induced pluripotent stem cell-derived neural stem/progenitor cell (hiPSC-NS/PC) line that is known to undergo tumorigenic transformation. Such approach enables selective ablation of the immature proliferating cells and thereby prevents subsequent tumor formation. In vitro, the HSVtk system successfully ablated the immature proliferative neural cells while preserving mature postmitotic neuronal cells. Similar results were observed in vivo following transplantation into the injured spinal cords of immune-deficient (nonobese diabetic–severe combined immune-deficient) mice. Ablation of the proliferating cells exerted a protective effect on the motor function which was regained after transplantation, simultaneously defending the spinal cord from the harmful tumor growth. These results suggest a potentially promising role of suicide genes in opposing tumorigenesis during stem cell therapy. This system allows both preventing and treating tumorigenesis following hiPSC-NS/PC transplantation without sacrificing the improved motor function. Stem Cells Translational Medicine 2019;8:260&270
Organic Ionic Plastic Crystal‐polymer Solid Electrolytes with High Ionic Conductivity and Mechanical Ability for Solid‐state Lithium Ion Batteries
Authors: Yang Kaihua , Zhang Zhengxi , Liao Zhu , Yang Li , Hirano Shin‐ichi 
Published: November 2018

AbstractSolid electrolytes (SEs) would be an ideal solution to safety concerns, miniaturization and increase of energy density; however, SEs are difficult to have high ionic conductivity and mechanical properties simultaneously. In this work, we firstly synthesize a novel class of ammonium‐based organic ionic plastic crystals (OIPCs), then prepare SE system by blending synthesized OIPC with poly(vinylidenefluoride‐co‐hexafluoropropylene) (P(VDF‐HFP)) and lithium bis(fluorosulfonyl)imide (LiFSI). Such SEs overcome most of the limitations, with attractive ionic conductivity and lithium ion transference number, excellent mechanical properties, high electrochemical stability, as well as satisfactory interfacial stability with lithium metal. In particular, Li/LiFePO4 cells employing as‐prepared SE exhibit high discharge capacity, favorable cycling and rate performance at 30 °C, which is comparable to those using liquid electrolytes. The reported SE system, combined with excellent overall performance, is expected to have great potential for application in solid‐state lithium ion batteries.
Betaine + (Glycerol or Ethylene Glycol or Propylene Glycol) Deep Eutectic Solvents for Extractive Purification of Gasoline
Authors: Kučan Kristina Zagajski , Perković Marijana , Cmrk Karlo , Načinović Dominik , Rogošić Marko 
Published: November 2018

AbstractDeep eutectic solvents (DES), a class of ′green′ solvents, are being tested for extractive desulfurization, denitrification and dearomatization of fuels. Here, three DESs were prepared by combining betaine (B) with glycerol (Gly), ethylene glycol (EG) or propylene glycol (PG) in the molar ratios of 1:3, 1:3 and 1:3.5, respectively. The DESs were used for the removal of thiophene, pyridine and toluene from a 6‐component model gasoline and for the removal of sulfur and nitrogen compounds from a real fluid catalytic cracking (FCC) gasoline. Physical properties of the prepared DESs – density, viscosity, refractive index, specific conductance, thermal conductivity, temperature diffusivity and heat capacity were determined, too. All tested DESs exhibit higher potential for denitrification of model fuel with respect to desulfurization and dearomatization. B‐PG 1:3.5 worked best in one‐stage denitrification of both model gasoline (∼80%) and real FCC gasoline (∼36%). The reuse of solvent without loss in extraction efficiency in four extraction stages was successfully achieved for all three DESs by evaporation purification of DES between the stages.
Binder‐Free ZnO Cathode synthesized via ALD by Direct Growth of Hierarchical ZnO Nanostructure on Current Collector for High‐Performance Rechargeable Aluminium‐Ion Batteries
Authors: Pal Dipayan , Mathur Aakash , Singh Ajaib , Pakhira Srimanta , Singh Rinki , Chattopadhyay Sudeshna 
Published: November 2018

AbstractNanoscale ZnO, directly grown on current collector through ALD, shows high electrochemical performance as a binder‐free cathode for rechargeable Al‐ion batteries (AIBs). Al coin cell fabricated using binder‐free ALD grown ZnO cathode (ZnO‐ALD‐E) manifests an initial discharge capacity of 2563 mAh g‐1, and remains at 245 mAh g‐1 at a current rate of 400 mA g‐1 after 50 cycles with almost 95% Coulombic efficiency. Distinct and consistent plateaus in discharge/charge curves reveal the Al‐ion insertion/extraction process and electrochemical stability of the battery. The delivered discharge capacity of the battery with ZnO‐ALD‐E cathode is significantly higher (1000%) than that of batteries fabricated using a conventional ZnO cathode composed of ZnO powder (nanoparticles or bulk) and binder with conductive carbon. Ex‐situ XRD and Photoluminescence spectroscopy in different discharge/charge states of Al/ZnO‐ALD‐E battery reveal the structural information of ZnO‐ALD‐E, upon Al‐ion intercalation/deintercalation. Such remarkable electrochemical performance is attributed to the binder‐free, well‐defined textured nanostructures of ALD grown ZnO cathode with c‐axis orientation along the surface normal, facilitating good electrical contact and enhanced pathways for electron/ion transfer/transport kinetics. First principle based DFT calculations explain the Al‐ion intercalation phenomena in the framework of c‐axis oriented ZnO. The proposed concept provides a strategy for transitioning to next‐generation AIBs with a binder‐free cathode.
Enantioselective Synthesis of (R)‐Antofine and (R)‐Cryptopleurine
Authors: Ansari Anas , Ramapanicker Ramesh 
Published: November 2018

AbstractEnantioselective syntheses of (R)‐antofine and (R)‐cryptopleurine starting from a 3‐phenanthrenylpropanal derivative are reported. Asymmetric α‐amination of this aldehyde is carried out in the presence of D‐proline, which constitutes the key step in the syntheses and resulted in the formation of the new stereogenic center with very high enantioselectivity (94% ee). The indolizidine and quinolizidine moieties in the target molecules are formed through Pictet‐Spengler reaction. The current method is shorter and high yielding in comparison with a similar strategy used for the synthesis of these molecules using proline‐catalyzed α‐hydroxylation of the same aldehyde.
The effect of citrus ginger aroma on heart rate and salivary cortisol level during sleep at home
Authors: Jiang Fang , Kobayashi Takemi , Ichihashi Takurou , Ito Kanetoshi , Nomura Shusaku 
Published: November 2018

The aim of this study is to investigate the effect of odor on the heart rate (HR) and salivary cortisol levels during sleep at home. Twenty male students (aged 20.9 ± 0.74 years) participated in the study and were exposed to three different odorants (apple, cedar wood, and citrus ginger) or a scentless control sample each night in their home environment in a counterbalanced order. In this within‐subjects study design, all subjects were instructed to sleep at home for 6 h, from 00:00 to 06:00, and HR was measured using a wristwatch‐type HR monitor. Saliva samples were obtained before sleep and after awakening. While subjective sleep quality at awakening did not differ between conditions, tension and anxiety, as assessed by the Profile of Mood State Questionnaire, significantly decreased from the night before sleep to the next morning on which citrus ginger exposure was provided (p < 0.01). Moreover, HR during sleep and after awakening, as well as cortisol secretion after awakening, was significantly higher in the citrus ginger condition (p < 0.01–0.05). Hence, the inhalation of citrus ginger aroma during sleep may enhance sympathetic nervous and endocrine system activity while alleviating psychological tension and anxiety. © 2018 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Building Literacy Environments to Motivate African American Boys to Read
Authors: Thomas Katina L. 
Published: November 2018

AbstractThe early reading gap among diverse subgroups of students in schools has made teachers conscious of how students’ culture affects their perceptions of reading and the literacy materials now being used in classrooms. The reported racial and gender gap among elementary literacy readers leaves African American boys on the fringes of literacy growth and development. Therefore, teachers are responsible for implementing strategies to build an emergent and early literacy classroom that motivates all boys of color to enjoy reading at an early age while shining a positive spotlight on all student backgrounds. Adopting a culturally responsive approach to literacy, increasing student responsibility in the literacy selection process, and supplying culturally relevant texts that positively influence student self‐perception will foster motivation for male students of color who are marginalized during the literacy‐learning process.
From Spirituality to Responsible Leadership: Ignatian Discernment and Theory-U
Authors: Nullens Patrick 
Published: November 2018

AbstractIn its desire to build a bridge between self-awareness and morally responsible leadership, this chapter seeks to contribute to the theory of authentic leadership. The central thesis of this chapter is that Ignatian spiritual discernment is a valuable resource for making this connection. Ignatian Spirituality is directed at the world, the world beyond the self and the world beyond our primary experiences. It is inherently aimed at the common good and is therefore an interesting source when contemplating moral leadership. We will discuss the Spiritual Exercises of humility, silence, and detachment, the prevalence of emotions and imagination, ethical evaluation, and journaling and mentoring as means for increasing self-awareness. We will do this in dialogue with the new Theory-U. This, too, is an approach where societal meaning is fundamental and seeks to increase awareness and genuine openness to the future by letting go of the self. This makes for an interesting dialogue, leading to a deeper understanding of spiritual discernment.
Embodied Realism as Interpretive Framework for Spirituality, Discernment and Leadership
Authors: Barentsen Jack 
Published: November 2018

AbstractThere appear to be two ways of knowing, the one driven by scientific evidence, the other by practice and intuition. The concept of embodiment brings these two ways together. Embodiment is now widely studied, as in the disciplines of nursing (Benner), cultural psychology (Voestermans and Verheggen), and cognitive psychology (Lakoff and Johnson). These developments point to the philosophical perspective of “embodied realism,” as initially outlined by Merleau-Ponty and Dooyeweerd. Our human system of knowing is directed and limited by the way our bodies enable us to interface with the world we inhabit. It requires dialogue to transcend our individuality, without arriving at universals, as research on cognitive bias by Kahneman has demonstrated. The centrality of embodiment, then, implies that spirituality is not in opposition to material concerns, but rather that embodiment is foundational for spirituality, as evident in religious ritual practices as well as in the Christian confession of the Incarnation. Moreover, spiritual discernment takes shape, not as a disembodied practice of meditation to access the divine, but as embodied seeing, listening and feeling in a collective effort to understand God’s call in the middle of one’s rapidly changing world. Finally, leadership can be seen as the embodied performance of providing a safe holding environment amidst liminality in order to enable people to cope, to be transformed and to develop a new sense of personal and social identity.