bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Voltage‐Boosting Strategy Enabling a Low‐Frequency, Flexible Electromagnetic Wave Absorption Device
Authors: Lv Hualiang , Yang Zhihong , Wang Paul Luyuan , Ji Guangbin , Song Jizhong , Zheng Lirong , Zeng Haibo , Xu Zhichuan J. 
Published: March 2018

AbstractNowadays, low‐frequency electromagnetic interference (<2.0 GHz) remains a key core issue that plagues the effective attenuation performance of conventional absorption devices prepared via the component‐morphology method (Strategy I). According to theoretical calculations, one fundamental solution is to develop a material that possesses a high ε′ but lower ε″. Thus, it is attempted to control the dielectric values via applying an external electrical field, which inducts changes in the macrostructure toward a performance improvement (Strategy II). A sandwich‐structured flexible electronic absorption device is designed using a carbon film electrode to conduct an external current. Simultaneously, an absorption layer that is highly responsive to an external voltage is selected via Strategy I. Relying on the synergistic effects from Strategies I and II, this device demonstrates an absorption value of more than 85% at 1.5–2.0 GHz with an applied voltage of 16 V while reducing the thickness to ≈5 mm. In addition, the device also shows a good absorption property at 25–150 °C. The method of utilizing an external voltage to break the intrinsic dielectric feature by modifying a traditional electronic absorption device is demonstrated for the first time and has great significance in solving the low‐frequency electromagnetic interference issue.
A High Efficacy Self‐Charging MoSe2 Solid‐State Supercapacitor Using Electrospun Nanofibrous Piezoelectric Separator with Ionogel Electrolyte
Authors: Pazhamalai Parthiban , Krishnamoorthy Karthikeyan , Mariappan Vimal Kumar , Sahoo Surjit , Manoharan Sindhuja , Kim Sang‐Jae 
Published: March 2018

AbstractSelf‐charging supercapacitor power cell (SCSPC) received much attention for harvesting and storing energy in an integrated device, which paves the way for developing maintenance free autonomous power systems for various electronic devices. In this work, a new type of SCSPC device is fabricated comprising 2D molybdenum di‐selenide (MoSe2) as an energy storing electrode with polyvinylidene fluoride‐co‐hexafluoropropylene/tetraethylammonium tetrafluoroborate (PVDF‐co‐HFP/TEABF4) ion gelled polyvinylidene fluoride/sodium niobate (PVDF/NaNbO3) as the piezopolymer electrolyte. The fabricated SCSPC delivers a specific capacitance of 18.93 mF cm−2 with a specific energy of 37.90 mJ cm−2 at a specific power density of 268.91 µW cm−2 obtained at a constant discharge current of 0.5 mA. The MoSe2 SCSPC device can be self‐charged with the aid of mechanical deformation induced using the applied compressive force, thus making it harvest and store energy. The MoSe2 SCSPC device can be charged up to a maximum of 708 mV under a compressive force of 30 N in 100 s, and the mechanism of charge‐storage is discussed in detail. The experimental findings of this work demonstrate the high efficiency of the fabricated MoSe2 SCSPC device, which can provide new insights for developing sustainable power sources for the next generation wearable electronic applications.
Surface‐Improved Asymmetric Michael Addition Catalyzed by Amino Acids Adsorbed on Laponite
Authors: Szőllősi György , Gombkötő Dániel , Mogyorós Attila Zsolt , Fülöp Ferenc 
Published: March 2018

AbstractAn unprecedented enantioselectivity increase was observed in the presence of inorganic oxides in the asymmetric Michael addition of aldehydes to trans‐β‐nitrostyrene derivatives catalyzed by amino acids. The best results were reached in the l‐proline catalyzed addition of linear aldehydes using laponite RD as additive, approaching those obtained using synthetic chiral organocatalysts. In our study we have shown that the asymmetric Michael addition is catalyzed by the organic‐inorganic hybrid material formed in situ by adsorption of the amino acid on the solid surface. The chiral solid catalyst could be pre‐prepared and recycled several times with maintained stereoselectivities, showing a slow decrease in the activity, which could be restored by adding proline during reuse. Characterization of the chiral hybrid material by FT‐IR spectroscopy and XRD measurements indicated anchoring of the proline on the surface of the laponite particles. Effect of the chiral organocatalyst structure was used to evidence the involvement of both the carboxylic acid and the amino group in anchoring the organic compound on the solid surface. Linear natural amino acids became also active in the asymmetric Michael addition following adsorption on laponite and provided the opposite enantiomer in excess as compared with l‐proline. The heterogeneous catalyst was applied in reactions of various carbonyl compounds and substituted nitrostyrene derivatives. Based on results obtained in this study combined with the previously reported amino acid catalyzed reactions on solid surfaces and the recently revisited reaction mechanism of this asymmetric addition a plausible reaction pathway occurring on the surface was proposed.magnified image
Occupational exposure to asphalt fume can cause oxidative DNA damage among road paving workers
Authors: Bal Ceylan , Ağış Erol R. , Büyükşekerci Murat , Gündüzöz Meşide , Tutkun Lütfiye , Yılmaz Ömer H. 
Published: March 2018

ObjectivesWe designed the present study to determine the effect of occupational exposure to asphalt fumes on oxidative status and DNA damage in road paving workers.MethodsSixty road paving workers exposed to asphalt fumes and forty non‐exposed control subjects were recruited. Occupational exposure to PAHs was assessed by urinary 1‐hydroxypyrene (1‐OHP) excretion. Serum thiol disulfide homeostasis (TDH), total oxidant status (TOS) and total antioxidant status (TAS) and urinary 8‐hydro‐deoxyguanosine (8‐OH‐dG) level were evaluated by automated colourimetric method.ResultsThe urinary concentrations of 1‐OHP and 8‐OH‐dG were significantly higher in the exposed group than in the control group (P < 0.001). Disulfide/thiol ratio, TOS, and TAS were also significantly higher for the asphalt workers. A positive correlation existed between urinary 1‐OHP and 8‐OH‐dG, TOS and TAS.ConclusionStudy results indicate that exposure to PAHs induces oxidative stress and causes genotoxic effects in asphalt workers.
Promotion effect of additive Fe on Al2O3 supported Ni catalyst for CO2 methanation
Authors: Li Zhenhua , Zhao Tingting , Zhang Lijuan 
Published: March 2018

In this paper, the effect of additive Fe on Ni/Al2O3 catalyst for CO2 methanation was studied. A series of bimetallic Ni–Fe catalysts with different Ni/Fe ratios were prepared by impregnation method. For comparison, monometallic Fe‐based and Ni‐based catalysts were also prepared by the same method. The characterization results showed that adding Fe to Ni catalyst on the premise of a low Ni loading(≦12 wt.%) enhanced CO2 methanation performance. However, when the Ni loading reached 12 wt.%, the catalytic activity decreased with the increase of Fe content, but still higher than the corresponding Ni‐based catalyst without Fe. Among them, the 12Ni3Fe catalyst exhibited the highest CO2 conversion of 84.3 % and nearly 100% CH4 selectivity at 50000 ml g‐1 h‐1 and 420 °C. The enhancement effect of adding Fe on CO2 methanation was attributed to the dual effect of suitable electronic environment and increased reducibility generated by Fe species.
Identification of an Amino Acid Motif in HLA–DRβ1 That Distinguishes Uveitis in Patients With Juvenile Idiopathic Arthritis
Authors: Haasnoot Anne‐Mieke J. W. , Schilham Marco W. , Kamphuis Sylvia , Hissink Muller Petra C. E. , Heiligenhaus Arnd , Foell Dirk , Minden Kirsten , Ophoff Roel A. , Radstake Timothy R. D. J. , Den Hollander Anneke I. , Reinards Tjitske H. C. M. , Hiddingh Sanne , Schalij‐Delfos Nicoline E. , Hoppenreijs Esther P. A. H. , van Rossum Marion A. J. , Wouters Carine , Saurenmann Rotraud K. , van den Berg J. Merlijn , Wulffraat Nico M. ,   ICON‐JIA Study Group, ten Cate Rebecca , de Boer Joke H. , Pulit Sara L. , Kuiper Jonas J. W. 
Published: March 2018

ObjectiveUveitis is a visually debilitating disorder that affects up to 30% of children with the most common forms of juvenile idiopathic arthritis (JIA). The disease mechanisms predisposing only a subgroup of children to uveitis are unknown. This study was undertaken to identify genetic susceptibility loci for uveitis in JIA, using a genome‐wide association study in 522 children with JIA.MethodsTwo cohorts of JIA patients with ophthalmologic follow‐up data were genotyped. Data were then imputed using a genome‐wide imputation reference panel, and an HLA‐specific reference panel was used for imputing amino acids and HLA types in the major histocompatibility complex (MHC). After imputation, genome‐wide and MHC‐specific analyses were performed, and a reverse immunology approach was utilized to model antigen presentation at 13 common HLA–DRβ1 alleles.ResultsPresence of the amino acid serine at position 11 (serine 11) in HLA–DRβ1 was associated with an increased risk of uveitis in JIA patients (odds ratio [OR] 2.60, P = 5.43 × 10−10) and was specific to girls (Pfemales = 7.61 × 10−10 versus Pmales = 0.18). Serine 11 resides in the YST motif in the peptide‐binding groove of HLA–DRβ1; all 3 amino acids in this motif are in perfect linkage disequilibrium and show identical association with disease. Quantitative prediction of binding affinity revealed that HLA–DRβ1 alleles with the YST motif could be distinguished on the basis of discernable peptide‐binding preferences.ConclusionThese findings highlight a genetically distinct, sexually dimorphic feature of JIA with uveitis as compared to JIA without uveitis. The association could be indicative of the potential involvement of antigen presentation by HLA–DRβ1 in the development of uveitis in JIA. The results of this study may advance our progress toward improved treatments for, and possible prevention of, the sight‐threatening complications of uveitis in children with JIA.
Mechanism of Phosphine‐Catalyzed Allene Coupling Reactions: Advances in Theoretical Investigations
Authors: Cui Cheng‐Xing , Shan Chunhui , Zhang Yu‐Ping , Chen Xiao‐Lan , Qu Ling‐Bo , Lan Yu 
Published: March 2018

AbstractOrganocatalysis has emerged as an effective strategy for chemical synthesis. Within this area, phosphine‐catalyzed coupling reactions have attracted considerable attention because of their versatility and wide range of applications in the construction of new C−C bonds. Recently, various experimental studies on the phosphine‐catalyzed coupling reaction of allenes have been reported, and mechanistic and computational studies have also progressed considerably. As a nucleophile, phosphine can react with an allene to form a zwitterionic phosphoniopropenide intermediate. After stepwise cycloaddition and proton transfer, the phosphine catalyst can be regenerated by C−P bond cleavage. Alternatively, the zwitterionic phosphoniopropenide intermediate could also be protonated by a Brønsted acid to generate a phosphonium intermediate, which can be used to construct new C−C bonds by electrophilic addition. In this review, we have summarized details of mechanistic studies of phosphine‐catalyzed allene coupling reactions that follow these two reaction modes. In addition to detailing the reaction pathway, the regioselectivity and diastereoselectivity of the phosphine‐catalyzed allene coupling reaction are also discussed in this review.
Formation of Supramolecular Nanotubes by Self‐assembly of a Phosphate‐linked Dimeric Anthracene in Water
Authors: Yu Hao , Sabetti Mattia , Häner Robert 
Published: March 2018

AbstractThe assembly of supramolecular polymers from a phosphodiester‐linked dimeric anthracene is described. AFM and TEM imaging reveals that the supramolecular polymers self‐assemble into nanotubes in water. Subsequent photodimerization experiments indicate that the supramolecular polymerization occurs via end‐to‐end stacking rather than an interdigitation arrangement of the building blocks.
Discrete-choice experiment to analyse preferences for centralizing specialist cancer surgery services
Authors: Vallejo-Torres L , Melnychuk M , Vindrola-Padros C , Aitchison M , Clarke C S , Fulop N J , Hines J , Levermore C , Maddineni S B , Perry C , Pritchard-Jones K , Ramsay A I G , Shackley D C , Morris S 
Published: March 2018

Abstract

Background
Centralizing specialist cancer surgery services aims to reduce variations in quality of care and improve patient outcomes, but increases travel demands on patients and families. This study aimed to evaluate preferences of patients, health professionals and members of the public for the characteristics associated with centralization.

Methods
A discrete-choice experiment was conducted, using paper and electronic surveys. Participants comprised: former and current patients (at any stage of treatment) with prostate, bladder, kidney or oesophagogastric cancer who previously participated in the National Cancer Patient Experience Survey; health professionals with experience of cancer care (11 types including surgeons, nurses and oncologists); and members of the public. Choice scenarios were based on the following attributes: travel time to hospital, risk of serious complications, risk of death, annual number of operations at the centre, access to a specialist multidisciplinary team (MDT) and specialist surgeon cover after surgery.

Results
Responses were obtained from 444 individuals (206 patients, 111 health professionals and 127 members of the public). The response rate was 52·8 per cent for the patient sample; it was unknown for the other groups as the survey was distributed via multiple overlapping methods. Preferences were particularly influenced by risk of complications, risk of death and access to a specialist MDT. Participants were willing to travel, on average, 75 min longer in order to reduce their risk of complications by 1 per cent, and over 5 h longer to reduce risk of death by 1 per cent. Findings were similar across groups.

Conclusion
Respondents' preferences in this selected sample were consistent with centralization.
Probing the Outstanding Local Hydrophobicity Increases in Peptide Sequences Induced by Incorporation of Trifluoromethylated Amino Acids
Authors: Gadais Charlène , Devillers Emmanuelle , Gasparik Vincent , Chelain Evelyne , Pytkowicz Julien , Brigaud Thierry 
Published: March 2018

AbstractIn order to achieve accurate determination of the local hydrophobicity increases in peptide sequences produced by incorporation of trifluoromethylated amino acids (TfmAAs), the chromatographic hydrophobicity indexes (ϕ0) of three series of tripeptides containing three unnatural trifluoromethylated amino acids have been measured and compared with those of their non‐fluorinated analogues. The hydrophobic contribution of each fluorinated amino acid was quantified by varying the position and the protection of (R)‐ and (S)‐α‐trifluoromethylalanine (TfmAla), (R)‐trifluoromethylcysteine (TfmCys), and (S)‐trifluoromethionine (TFM) in a short peptide sequence. As a general trend, strong increases in hydrophobicity were precisely measured, even exceeding the high hydrophobic contribution of the natural amino acid isoleucine. This study validates the incorporation of trifluoromethylated amino acids into peptide sequences as a rational strategy for the fine‐tuning of hydrophobic peptide–protein interactions.
Absorb bioresorbable vascular scaffold vs. everolimus‐eluting metallic stent in small vessel disease: A propensity matched analysis of COMPARE II, RAI, and MAASSTAD‐ABSORB studies
Authors: Tarantini Giuseppe , Masiero Giulia , Barioli Alberto , Paradies Valeria , Vlachojannis Georgios , Tellaroli Paola , Cortese Bernardo , di Palma Gaetano , Varricchio Attilio , Ielasi Alfonso , Loi Bruno , Steffenino Giuseppe , Ueshima Daisuke , Mojoli Marco , Smits Pieter 
Published: March 2018

AbstractBackgroundPatients with small vessel disease (SVD) are at higher risk of adverse events after PCI compared to non‐SVD patients. In this subset, the use of bioresorbable vascular scaffolds (BVS) has raised particular concern.ObjectiveWe aimed to compare outcomes of Absorb BVS versus a 2nd‐generation metallic everolimus‐eluting stents (EES) in the SVD setting, by pooling patients from three large, prospective studies.MethodsPatients with SVD (reference vessel diameter ≤2.75 mm by QCA) and treated with Absorb BVS were identified in the Italian RAI and the MAASSTAD‐Absorb registries. EES controls were identified in the COMPARE II Trial. We performed a propensity‐score matching using several clinical and angiographic variables. Implantation technique was not object of matching, being device‐specific.ResultsOut of 4635 enrolled subjects, 1147 belonged to the SVD population. After matching, we obtained 337 pairs of patients. High clinical and angiographic complexity was found in both groups. Predilation and postdilation rates were significantly higher in BVS patients. No differences were found in terms of the device‐oriented composite end‐point at 1‐year (HR = 1.08, 95%CI 0.5–2.3, P = .8) and 2‐years (HR = 1.28, 95% CI: 0.68–2.43, P = .5). Notwithstanding, higher incidence of definite/probable stent thrombosis was observed in the BVS group at 1 year (HR 4.7, 95%CI 0.8–31.4, P = .08) and 2‐years (HR = 8.34 95%CI 1.1–60.2, P = .04).ConclusionIn this propensity‐matched analysis pooling SVD patients of three large prospective studies, incidence of composite device‐related events was comparable between BVS and EES up to 2 years follow‐up. However, higher rates of stent thrombosis were found in the BVS group.
Radical Diazidation of Alkenes: Cu/Fe/Mn Catalysis and Electrochemical Support
Authors: Ahmed Nisar , Khatoon Saira , Shirinfar Bahareh 
Published: March 2018

AbstractThe synthetic routes for C‐N3 bond formation through a radical mechanism with the use of transition metals provide efficient diazide products, which can be further applied in many transformations to synthesize various valuable nitrogen‐containing compounds of pharmaceutical interest. The reported methods evidence stoichiometric heavy metals and toxic reagents (as N3‐source) and generally exhibit a limited substrate scope. However, the electrochemical diazidations are found to be environmentally friendly and very simple, while also providing a highly efficient way to synthesize 1,2‐diazide derivatives. Moreover, they provide a smart alternative for easy access to 1,2‐diamines, which can be used for future modern syntheses.
Copper‐Catalyzed Regio‐ and Enantioselective Aminoboration of Unactivated Terminal Alkenes
Authors: Kato Kodai , Hirano Koji , Miura Masahiro 
Published: March 2018

AbstractA CuCl/(R,R)‐PTBP‐BDPP‐catalyzed regioselective and enantioselective aminoboration of simple and unactivated terminal alkenes with bis(pinacolato)diboron (pinB‐Bpin) and hydroxylamines has been developed. The amino group and boryl group were incorporated at the internal position and terminal position, respectively, and the corresponding chiral β‐borylalkylamines were obtained with good to high enantiomeric ratios. The asymmetric copper catalysis allows rapid and concise transformation of readily available olefinic feedstock‐like materials into functionalized chiral alkylamines of high potential in medicinal and pharmaceutical chemistry.
Startup of divided wall column for high purity separation of aromatic reformate
Authors: Wu Hao , Shen Benxian , Ling Hao 
Published: March 2018

AbstractStartup of distillation columns is one of the most difficult operations in the distillation process. Although the design and control of divided wall column (DWC) is mature recently, the startup procedure for divided wall columns still suffers a lack of knowledge. This paper investigates a startup policy of a pilot divided wall column used for high purity separation of an aromatic reformate. The aromatic reformate contains benzene, toluene, ethylbenzene, p‐xylene, m‐xylene, and o‐xylene. Very high product purities above 99.95 wt% are specified. The proposed startup procedure is consisted of four steps, including total‐reflux, benzene withdrawn, toluene withdrawn, and continuous feeding. This startup procedure has been successfully applied to the DWC pilot plant used for high purity separation of the aromatic reformate. Temperature and composition profiles of each step are presented. These profiles are used for determining the switching points of the near two steps and understanding the dynamic behaviour of the DWC.
Design of Modular G‐quadruplex Ligands
Authors: Duarte Ana Rita , Cadoni Enrico , Ressurreição Ana S. , Moreira Rui , Paulo Alexandra 
Published: March 2018

AbstractGuanine‐rich nucleic acid sequences able to form four‐stranded structures (G‐quadruplexes, G4) play key cellular regulatory roles and are considered as promising drug targets for anticancer therapy. On the basis of the organization of their structural elements, G4 ligands can be divided into three major families: one, fused heteroaromatic polycyclic systems; two, macrocycles; three, modular aromatic compounds. The design of modular G4 ligands emerged as the answer to achieve not only more drug‐like compounds but also more selective ligands by targeting the diversity of the G4 loops and grooves. The rationale behind the design of a very comprehensive set of ligands, with particular focus on the structural features required for binding to G4, is discussed and combined with the corresponding biochemical/biological data to highlight key structure–G4 interaction relationships. Analysis of the data suggests that the shape of the ligand is the major factor behind the G4 stabilizing effect of the ligands. The information here critically reviewed will certainly contribute to the development of new and better G4 ligands with application either as therapeutics or probes.
Supramolecular Assembly of Thiolated Cyclodextrin and Ferrocene Derivative for Controlled Drug Delivery
Authors: Cheng Jian‐Guang , Zhang Ying‐Ming , Liu Yu 
Published: March 2018

AbstractConstruction of biocompatible nanoparticles is a significant topic of research at the chemistry/biology interface. Presently, more and more researchers have focused on supramolecular amphiphiles constructed by macrocycle‐induced aggregation, a feasible and universal strategy in the fabrication of functional nanomaterials. In this work, we report a pH‐responsive nanoparticle through a noncovalent complexation between per‐6‐thiolated β‐cyclodextrin sodium salt (SACD) and amphiphilic ferrocene derivative (FC12+Br−) in water. The formation and composition of the obtained supramolecular nanoparticles were comprehensively characterized by UV/Vis absorption, dynamic laser scattering, and microscopic observations. Furthermore, the drug loading and release studies demonstrated that the supramolecular binary nanoparticles could efficiently encapsulate doxorubicin hydrochloride (DOX) in their nanoparticulate cores, and the entrapped DOX could be rapidly released in a low pH environment. The present study suggests that the obtained binary supramolecular amphiphiles with good stability, tunable assembling/disassembling behaviors, and controlled drug loading/release properties have great potential in the construction of on‐demand drug‐delivery systems.