bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the MHC I Immunopeptidome Repertoire of B‐Cell Lymphoblasts Using Two Isolation Methods
Authors: Lanoix Joël , Durette Chantal , Courcelles Mathieu , Cossette Émilie , Comtois‐Marotte Simon , Hardy Marie‐Pierre , Côté Caroline , Perreault Claude , Thibault Pierre 
Published: March 2018

AbstractSignificant technological advances in both affinity chromatography and mass spectrometry have facilitated the identification of peptides associated with the major histocompatibility complex class I (MHC I) molecules, and enabled a greater understanding of the dynamic nature of the immunopeptidome of normal and neoplastic cells. While the isolation of MHC I‐associated peptides (MIPs) typically used mild acid elution (MAE) or immunoprecipitation (IP), limited information currently exists regarding their respective analytical merits. Here, a comparison of these approaches for the isolation of two different B‐cell lymphoblast cell models is presented, and it is reported on the recovery, reproducibility, scalability, and complementarity of identification from each method. Both approaches yielded reproducible datasets for peptide extracts obtained from 2 to 100 million cells, with 2016 to 5093 MIPs, respectively. The IP typically provides up to 6.4‐fold increase in MIPs compared to the MAE. The comprehensiveness of these immunopeptidome analyses is extended using personalized genomic database of B‐cell lymphoblasts, and it is discovered that 0.4% of their respective MIP repertoire harbored nonsynonymous single nucleotide variations (also known as minor histocompatibility antigens, MiHAs).
Swendsen‐Wang algorithm on the mean‐field Potts model
Authors: Galanis Andreas , Štefankovič Daniel , Vigoda Eric 
Published: March 2018

AbstractWe study the q‐state ferromagnetic Potts model on the n‐vertex complete graph known as the mean‐field (Curie‐Weiss) model. We analyze the Swendsen‐Wang algorithm which is a Markov chain that utilizes the random cluster representation for the ferromagnetic Potts model to recolor large sets of vertices in one step and potentially overcomes obstacles that inhibit single‐site Glauber dynamics. Long et al. studied the case q = 2, the Swendsen‐Wang algorithm for the mean‐field ferromagnetic Ising model, and showed that the mixing time satisfies: (i) for , (ii) for , (iii) for , where βc is the critical temperature for the ordered/disordered phase transition. In contrast, for there are two critical temperatures that are relevant. We prove that the mixing time of the Swendsen‐Wang algorithm for the ferromagnetic Potts model on the n‐vertex complete graph satisfies: (i) for , (ii) for , (iii) for , and (iv) for . These results complement refined results of Cuff et al. on the mixing time of the Glauber dynamics for the ferromagnetic Potts model.
Confirmation of the Structure of Trans‐Cyclic Azobenzene by X‐Ray Crystallography and Spectroscopic Characterization of Cyclic Azobenzene Analogs
Authors: Jun Meesook , Joshi Dhruval K. , Yalagala Ravi S. , Vanloon Jesse , Simionescu Razvan , Lough Alan J. , Gordon Heather L. , Yan Hongbin 
Published: March 2018

AbstractThe photoisomerization properties of a series of cyclic azobenzene (cAb) analogs, including non‐substituted, Br‐, CN‐, carboxyl‐, and amino cAb, were compared. While the trans‐form of these analogs show different degrees of thermal stability, no spectral changes in the absorption wavelengths were observed for amino cAb upon exposure to purple light. The 15N NMR chemical shifts of cAb in both cis‐ and trans‐forms were found to show a large difference from those of aromatic azobenzene; however, the trend of difference in chemical shift is in agreement with that obtained from quantum chemical calculations. More importantly, the structure of the photoisomerization product from cis‐cAb was confirmed to be, indeed, the trans‐cAb by X‐ray diffraction experiments. The 15NMR data of the cAb isomers and confirmation of trans‐cAb through crystal structure will be of importance for future studies in the design and applications of cAb as a photoswitch.
An Ultrafast Transient Absorption Study of Charge Separation and Recombination Dynamics in CdSe QDs and Methyl Viologen: Dependence on Surface Stoichiometry
Authors: Sekhar M. Chandra , Paul Sneha , De Apurba , Samanta Anunay 
Published: March 2018

AbstractThe dependence of the dynamics of charge separation and recombination between methyl viologen (MV+2) and photo‐excited CdSe quantum dots (QDs) on the surface stoichiometry of the latter is studied for QDs with different Cd:Se mole ratios employing ultrafast time‐resolved absorption and emission measurements. The electron transfer rates between photoexcited CdSe QDs and MV+2 are measured directly by monitoring the ultrafast rise and decay of the transient absorption signal due to methyl viologen monocationic radical (MV+•). The results show that both forward and back electron transfer rates (5±1 x 1012 s−1 and 1.3±0.3 x 1010 s−1, respectively) are independent of the stoichiometry of the QDs. Interestingly, the efficiency of the electron transfer process, estimated from the yield of MV+•, shows significant dependence on the nature of the QDs, with maximum yield (Φrs=0.52±0.01) observed in the case of Cd‐rich QDs. These findings are explained considering the energetics and surface trap states of these systems.
The role of social proximity in professional CEO appointments: Evidence from caste/religion‐based hiring of CEOs in India
Authors: Damaraju Naga Lakshmi , Makhija Anil K. 
Published: March 2018

Research Summary: The role of homophily in CEO appointments at the largest corporations is an important subject in corporate governance. This subject is particularly important in a country like India where a multitude of religions, castes, and communities form its social fabric. We test for the role of homophily in professional CEO appointments in India by empirically examining the preference for same caste/religion CEOs by the largest firms. Using a unique dataset, assembled by detailed identification of castes/religions from family names and counterfactuals obtained through the Coarsened Exact Matching technique, we find that caste/religion plays a crucial role in CEO selection as a source of information (positive discrimination). The evidence is not consistent with its use to pursue taste‐based preferences (negative discrimination).Managerial Summary: We test for the role of homophily in the appointments of CEOs in India by empirically examining the preference for same caste/religion CEOs by the largest firms. We find that caste/religion plays an important role in CEO selection, i.e., as a form of information or “positive discrimination.” The evidence is not consistent with its use to pursue taste‐based preferences or “negative discrimination.”
One‐Step Hydrothermal Synthesis of Nitrogen‐Doped Conjugated Carbonized Polymer Dots with 31% Efficient Red Emission for In Vivo Imaging
Authors: Liu JunJun , Li Daowei , Zhang Kai , Yang Mingxi , Sun Hongchen , Yang Bai 
Published: March 2018

AbstractCarbon dots with long‐wavelength emissions, high quantum yield (QY) and good biocompatibility are highly desirable for biomedical applications. Herein, a green, facile hydrothermal synthesis of highly efficient red emissive nitrogen‐doped carbonized polymer dots (CPDs) with optimal emission at around 630 nm are reported. The red emissive CPDs possess a variety of superior properties including excellent water dispersibility, good biocompatibility, narrow bandwidth emission, an excitation‐independent emission, and high QY (10.83% (in water) and 31.54% (in ethanol)). Further studies prove that such strong red fluorescence is ascribed to the efficient conjugated aromatic π systems and hydrogen bonds of CPDs. And the fluorescence properties of CPDs can be regulated by adjusting the dosage of HNO3 before the reaction. Additionally, the as‐prepared CPDs are successfully used as a fluorescent probe for bioimaging, both in vitro and in vivo. More importantly, biodistribution results demonstrate that most CPDs and their metabolites are not only excreted in urine but also excreted by hepatobiliary system in a rapid manner. Besides, the CPDs could easily cross the blood brain barrier, which may provide a valuable strategy for the theranostics of some brain diseases through real‐time tracking.
Experimental and analytical behavior of a new type of concrete‐filled steel tube tied‐arch bridge with trough girder
Authors: Wu Xun , Shen Gang , Gui Xing , Ling Zhimin , Chen Weizhen 
Published: March 2018

AbstractTrough girders are widely accepted in engineering on account of lowing construction depth and protection against traffic noise pollution, but most of them are used for simple‐supported girder bridges with a span of generally less than 30 m. On the railway line of Nanjing–Qidong in China a new railway bridge will be built which has a span of over 64 m but a construction depth of less than 2.4 m on which Shanghai–Nantong railway line is also passed, so the type of concrete‐filled steel tube tied‐arch bridge with trough girder was chosen. For such a new structure hardly used in engineering, there are no research results yet available about mechanical properties of the structure. This paper therefore makes for the bridge an experimental model of 1:4 geometric scale in order to test mechanical properties under operation load, cracking load, and ultimate load such as cracking diagram, load‐carrying capacity, stress distribution, and failure mechanism. According to the experimental results, when the model is subjected to longitudinal bending moment, the failure mode is similar to that of pure bending of a girder, and when the model is subjected to transverse bending moment failure mode behaves like the flexural failure mode of the traditional reinforced concrete structure. A non‐linear element analysis is also made on the model with the results in good agreement with that of the experiment. The same modeling method is applied to the finite element analysis of the real bridge, considering various load in design. In the analysis, it is finally verified that this new type of bridge meets specification requirements in strength, rigidity, and resistance to cracking.
Lebenszyklusorientierte Bewertung von Segmentbrücken in Stahlverbundbauweise
Authors: Berndorfer Claus , Hierl Martin , Mensinger Martin , Seidl Günter , Zinke Tim 
Published: March 2018

AbstractInnovationen bilden die Grundlage für Effizienzsteigerung. Im Brückenbau können innovative Bauweisen dazu beitragen, die in den nächsten Jahrzehnten anstehenden Sanierungs‐ und Ersatzbaumaßnahmen zu bewältigen. In diesem Beitrag wird der Schwerpunkt auf Segmentbrücken gelegt. Hierzu werden bereits erstellte Pilotprojekte beschrieben, Weiterentwicklungen erläutert und die Segmentbauweise hinsichtlich ihrer Leistungsfähigkeit im Lebenszyklus mit den beiden „klassischen” Bauweisen der Verbundfertigteilbrücken und Spannbetonbrücken verglichen. In die Gegenüberstellungen werden sowohl Herstellungs‐, Nutzungs‐ und Rückbaukosten als auch die monetarisierten Auswirkungen auf Verkehrsteilnehmer und das Umfeld integriert. Die Ergebnisse stellen eine ganzheitliche Bewertungsgrundlage bereit, die in Entscheidungsfindungen von Bauherren, Planern und Ausführenden einbezogen werden können.
Monobogen als Tor zum Spessart
Authors: Bäumler Tobias , Baumhauer Andreas 
Published: March 2018

AbstractDie Bundesautobahn A3 zählt zu den bedeutendsten Bundesautobahnen in Deutschland. Aufgrund der hohen Verkehrsbelastung wird die Bundesautobahn A3 zwischen Aschaffenburg und dem Autobahnkreuz Biebelried sechsstreifig ausgebaut. Ausgewählte Bauwerke im Streckenabschnitt erhalten eine besondere Gestaltung mit Wiedererkennungswert. Dazu zählt auch die Überführung der Staatsstraße 2312, der sogenannte Monobogen. Im Zuge des sechsstreifigen Ausbaus der Bundesautobahn A3 wird durch die Verlegung der Bundesautobahn A3 und der Staatsstraße 2312 ein neues Kreuzungsbauwerk erforderlich. Die Konzeption der neuen Brücke soll insbesondere der schiefwinkligen Kreuzungssituation Rechnung tragen. Entworfen wurde ein Tragwerk, welches in seiner Statik und Ansicht der Schiefe entgegenwirkt. Der diagonal über den Überbau spannende Monobogen mit beidseitigen Seilabspannungen kreuzt nahezu rechtwinklig die unterführte Bundesautobahn. Die regelmäßig angeordneten Seilaufhängungen ermöglichen ein sehr schlank gestaltetes Brückendeck, welches seine Wirkung unabhängig vom Betrachtungswinkel entfaltet. Der Bogen zeigt sich aufgrund seiner nahezu rechtwinklig zur Bundesautobahn gerichteten Anordnung unverfälscht in seiner wahren Bogenform. Die Form der Seilüberspannung ist neben statischen Aspekten von der architektonisch gestalteten, gekreuzten Hängeransicht geprägt. Für das architektonisch gestaltete Tragwerk wurden vollverschlossene Seile gewählt, da deren Außendurchmesser und die Geometrie der Verankerungen gegenüber Litzenseilen eher den Proportionen der filigranen Brückenkonstruktion mit den vergleichsweise kurzen Seillängen gerecht werden.
Eine Bogenbrücke als Stadttor für Riedlingen
Authors: Plieninger Sven , Sander Christiane , Behrmann Tilo 
Published: March 2018

AbstractIn Riedlingen an der Donau entsteht zurzeit eine neue Straßenbrücke über den Donauhochwasserkanal. Um der besonderen Lage als Stadteingang vor der historischen Altstadtkulisse gerecht zu werden, wurde 2003 im Rahmen eines Realisierungs‐ und Ideenwettbewerbs eine angemessene Lösung gesucht. Nachdem mittlerweile die Aufweitung des Kanals zur Gewährleistung des Hochwasserschutzes in Riedlingen weitgehend umgesetzt wurde, stellt der Neubau der Kanalbrücke mit größerer Spannweite und verbesserter Einbindung in das Radwegenetz eine der letzten noch ausstehenden Maßnahmen dar. Neben den Anforderungen in Bezug auf Wegeführung, Gestaltung und Hochwasserschutz wurde bei der Planung besonderer Wert darauf gelegt, die aus dem temporären Wegfall der Innenstadtanbindung resultierenden Beeinträchtigungen zu minimieren. Um die Fertigstellung innerhalb einer achtmonatigen Bauzeit zu ermöglichen, wurden im Werk vorgefertigte Stahlträger als Haupttragelemente verwendet. Eine weitere Maßnahme bestand in der Errichtung einer Fußgängerbrücke, die als permanente Querung auch nach Fertigstellung der Straßenbrücke eine nachhaltige Funktion zur Anbindung der für Freizeitaktivitäten genutzten „Donauinsel” erfüllt.
Schiffstoßsicherung der Alten Mainbrücke Zellingen
Authors: Sonnabend Stephan , Goldstein Martina , Mensinger Martin 
Published: March 2018

AbstractIm Jahre 1884 wurde zur Schaffung einer festen Mainquerung die „Alte Mainbrücke Zellingen” erbaut. Bauwerke aus dieser Zeit wurden nicht hinsichtlich eines möglichen Schiffstoßes bemessen. Im Zuge des fortschreitenden Ausbaues des Mains forderte das Wasserstraßen‐Neubauamt Aschaffenburg eine zeitgemäße Sicherung des Bauwerkes gegen Schiffstoß. Im nachfolgenden Aufsatz wird erläutert, auf welche Weise die „Alte Mainbrücke Zellingen” gegen Schiffstoß gesichert wurde. Die im gleichen Zuge erfolgten Instandsetzungsmaßnahmen zum Erhalt des Brückenbauwerkes werden dargelegt. Nach erfolgter Bauausführung wurde im Juni 2015 die ursprüngliche Straßenbrücke als Rad‐ und Fußgängerbrücke wieder für den Verkehr freigegeben.
A study of sliding motion of a solid body on a surface with asymmetric friction*
Authors: Silantyeva Olga , Dmitriev Nikita 
Published: March 2018

AbstractRecent studies show growing interest in materials with asymmetric friction forces. We investigate terminal motion of a solid body with a circular contact area. Assuming that friction forces are asymmetric orthotropic, we consider Hertz and Boussinesq laws for pressure distribution. Equations for friction force and moment are formulated and solved for both cases. Numerical examples demonstrate significant impact of the asymmetry of friction on the motion. Our results can be used for more accurate prediction of contact behavior for bodies made of new materials with asymmetric surface textures.
Numerical analysis of a contact problem in poro‐thermoelasticity with microtemperatures
Authors: Bazarra Noelia , Fernández José R. 
Published: March 2018

AbstractA dynamic contact problem, between a thermoelastic rod with voids and microtemperatures and a deformable obstacle, is numerically investigated in this work. The contact is modelled with a modification of the classical normal compliance contact condition. The mechanical problem consists of a coupled system of two hyperbolic partial differential equations and two parabolic ones. An existence and uniqueness result, and an energy decay property, are stated. Then, fully discrete approximations are introduced to approximate this nonlinear problem by using the finite element method and the implicit Euler scheme. A discrete stability property and a priori error estimates are proved, from which the linear convergence of the algorithm is derived. Finally, some numerical simulations are performed to demonstrate the accuracy of the approximation and the behaviour of the solution.
Chemoradiotherapy for Initially Unresectable Locally Advanced Cholangiocarcinoma
Authors: Sumiyoshi Tatsuaki , Shima Yasuo , Okabayashi Takehiro , Negoro Yuji , Shimada Yasuhiro , Iwata Jun , Matsumoto Manabu , Hata Yasuhiro , Noda Yoshihiro , Sui Kenta , Sueda Taijiro 
Published: March 2018

AbstractObjectiveSurgical resection is the only available treatment for achieving long‐term survival in cholangiocarcinoma. The purpose of this study is to elucidate the utility of chemoradiotherapy for initially unresectable locally advanced cholangiocarcinoma.MethodsUnresectable locally advanced cholangiocarcinoma was defined as those in which radical surgery could not be achieved even with aggressive surgical procedure. Fifteen candidates (7 intrahepatic cholangiocarcinomas and 8 hilar cholangiocarcinomas) underwent chemoradiotherapy. Fourteen of the 15 patients received oral S‐1 chemotherapy. Radiotherapy was administered with 50 Gy for each patient. After chemoradiotherapy, the resectability of each cholangiocarcinoma was reexamined.ResultsOf the 15 patients with initially unresectable locally advanced cholangiocarcinoma, 11 (73.3%) were judged to have resectable cholangiocarcinoma after chemoradiotherapy, and received radical hepatectomy (R0 resection in 9 patients). Among the 11 patients who underwent surgical resection, 4 had recurrence‐free survival and the median survival time (MST) was 37 months. The overall 1‐, 2‐, and 5‐year survival rates were 80.8, 70.7 and 23.6%, respectively. Among the 4 patients who were unable to receive surgery, 3 died of the primary disease and the MST was 10 months. The overall 1‐ and 2‐year survival rates were 37.5 and 0%, respectively. Patients who received radical surgery had significantly longer survival time than those who were unable to receive surgery (p = 0.027).ConclusionsChemoradiotherapy allowed patients with initially unresectable locally advanced cholangiocarcinomas to be reclassified as surgical candidates in a substantial proportion. Chemoradiotherapy might be one of the treatment options for similarly advanced cholangiocarcinomas.
Cross‐sectional and longitudinal atrophy is preferentially associated with tau rather than amyloid β positron emission tomography pathology
Authors: Gordon Brian A. , McCullough Austin , Mishra Shruti , Blazey Tyler M. , Su Yi , Christensen John , Dincer Aylin , Jackson Kelley , Hornbeck Russ C. , Morris John C. , Ances Beau M. , Benzinger Tammie L.S. 
Published: March 2018

AbstractIntroductionStructural magnetic resonance imaging is a marker of gray matter health and decline that is sensitive to impaired cognition and Alzheimer's disease pathology. Prior work has shown that both amyloid β (Aβ) and tau biomarkers are related to cortical thinning, but it is unclear what unique influences they have on the brain.MethodsAβ pathology was measured with [18F] AV‐45 (florbetapir) positron emission tomography (PET) and tau was assessed with [18F] AV‐1451 (flortaucipir) PET in a population of 178 older adults, of which 123 had longitudinal magnetic resonance imaging assessments (average of 5.7 years) that preceded the PET acquisitions.ResultsIn cross‐sectional analyses, greater tau PET pathology was associated with thinner cortices. When examined independently in longitudinal models, both Aβ and tau were associated with greater antecedent loss of gray matter. However, when examined in a combined model, levels of tau, but not Aβ, were still highly related to change in cortical thickness.DiscussionMeasures of tau PET are strongly related to gray matter atrophy and likely mediate relationships between Aβ and gray matter.
Male Sexual Quality Of Life Is Maintained Satisfactorily Throughout Life In The Amazon Rainforest
Authors: Teixeira Thiago , Nazima Maira , Hallak Jorge 
Published: March 2018

Abstract

Introduction
The Amazon Rainforest is a cradle of biodiversity, where different ethnic groups have specific sexual habits.

Aims
To define the average sexual quality of life of Amazonian men 18 to 69 years old, evaluate the influence of aging on their sexual function, and calculate the prevalence of premature ejaculation, delayed ejaculation, and hypoactive sexual desire disorder.

Methods
A cross-sectional quantitative probability sample study was performed with a demographically representative population (N = 385), with data collected privately at participants’ houses, including men who had been sexually active for a minimum of 6 months. The Male Sexual Quotient (MSQ) was used to measure sexual satisfaction and function. Statistical analysis was performed with SPSS 21.0 using the Kruskal-Wallis test (P &lt; .05), and a multiple linear regression analysis was performed to investigate which factors could predict participants’ quality of sexual life.

Main Outcome Measures
MSQ scores.

Results
The response rate was 81.69%. The mean age was 36.00 ± 12.95 years, and most men had mixed ethnicity (63.11%), were self-employed (42.07%), had a monthly earned income of US$0 to US$460 (46.75%), and were single (36.10%). The mean MSQ score was 80.39 ± 12.14 (highly satisfied). None of the demographic characteristics showed a statistically significant influence on sexual satisfaction. The difference in quality of sexual life was statistically significant compared with age (P &lt; .01). The domains of desire (P &lt; .01), partner satisfaction (P = .04), and erection quality (P &lt; .01, P = .03, P = .02) were statistically significant. Prevalences of sexual dysfunctions were 36.54% for premature ejaculation, 6.5% for delayed ejaculation, and 11.69% for hypoactive sexual desire disorder.

Conclusions
Independent of age, these men have an excellent quality of sexual life. Sexual domains such as desire, partner satisfaction, and erection quality are related to the correlation between sexual quality of life and aging. However, the prevalence of premature ejaculation seems to be slightly higher than in other parts of the world.