bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disentangling the facets of sharing
Authors: Trenz Manuel , Frey Alexander , Veit Daniel 
Published: June 2018

PurposeThe purpose of this paper is to develop a categorization of sharing practices from a structured interdisciplinary literature review on the Sharing Economy. Instead of striving for a new definition, the authors distinguish nine types of sharing practices and provide an overview of prior investigations on sharing practices across three levels of analysis and 15 research areas. The structured analysis is translated into opportunities for future research on the Sharing Economy.Design/methodology/approachThe study follows a structured literature review approach to uncover practices related to the Sharing Economy and similar phenomena. The authors analyze 210 articles from a broad number of disciplines, and develop a categorizing framework for Sharing Economy practices.FindingsThe paper identifies nine different types of sharing practices and provides a structured way for analyzing, comparing and positioning research on the Sharing Economy and related phenomena.Research limitations/implicationsThe categorization of sharing practices and the embedded interdisciplinary overview of studies on the Sharing Economy help to explain potentially contradictory research results and uncovers opportunities for future research in the topic area.Originality/valueGiven the variety of disciplines dealing with the Sharing Economy and the plenitude of definitions and related concepts, the categorization and research overview provides a consolidated view of the knowledge in the topic area and an effective tool for identifying paths for future research.
Does guanxi influence product performance and customer loyalty?
Authors: Zhang Man , Hartley Janet 
Published: June 2018

PurposeThis paper aims to propose and test a model examining the relationship of guanxi with new product performance and customer loyalty in the context of internationalizing small- and medium-sized enterprises (SMEs) in China. Social network theory and information processing theory provide the theoretical lenses for this research.Design/methodology/approachGuanxi with suppliers, distributors and customers is measured as a second-order construct consisting of ganqing, renqing, and xinren/xinyong. Research hypotheses are tested using survey data (n= 212) gathered in Anhui and Shandong Provinces. The data are analyzed using smart partial least squares technique.FindingsThe findings reinforce existing studies, which show that a locally based social network can be extended to the success of early-internationalizing SMEs. Results also suggest that the relationship between guanxi and customer loyalty is stronger when technical uncertainty is low and when market uncertainty is low rather than high.Research limitations/implicationsThe data were gathered from the point of view of the SMEs and may not accurately reflect the perspective of the foreign customer. The findings may not generalize beyond the regions surveyed. The study does not differentiate among the type of supply chain member, and the location of the supply chain member was not measured.Practical implicationsAlthough guanxi is typically viewed as being localized within a country, guanxi with suppliers, distributors and customers can provide information and resources needed for successful export products. Second, internationalizing SMEs must understand that even though guanxi has positive impact on new product performance which directly leads to customer loyalty only when uncertainty is low.Originality/valueAlthough guanxi has been studied, there are a limited number of empirical studies of guanxi in a supply chain context and most focus on buyers’ guanxi with suppliers. The research on guanxi with customers and distributors is also limited. This research addresses this gap by focusing on guanxi with suppliers, distributors and customers.
Regulation of p38 mitogen‐activated kinase‐mediated fetal membrane senescence by statins
Authors: Ayad Martina T. , Taylor Brandie D. , Menon Ramkumar 
Published: June 2018

ProblemOxidative stress (OS)‐induced, p38 mitogen‐activated protein kinase (p38MAPK)‐mediated chorioamniotic senescence and inflammation (senescence‐associated secretory phenotype [SASP]) are associated with parturition. In response to OS‐inducing risk factors, premature senescence contributes to preterm premature rupture of the membranes (pPROM) and spontaneous preterm birth (PTB). We determined the effect of simvastatin, rosuvastatin, and progesterone in downregulating p38MAPK‐mediated senescence and SASP.Method of StudyNormal term, not‐in‐labor fetal membranes (n = 8) were exposed to cigarette smoke extract (CSE: OS inducer) alone or combined with simvastatin (100 and 200 ng/mL), rosuvastatin (100 and 200 ng/mL), and progesterone (10−6 mol/L). p38MAPK expression changes were studied by Western blot, senescence was determined by senescence‐associated β‐Galactosidase (SA‐β‐Gal) staining, and multiplex analysis determined changes associated with 4 SASP markers (IL‐8, IL‐10, TNF‐α, and GM‐CSF). A pairwise comparison between groups was conducted by ANOVA.ResultsCompared to untreated controls, CSE induced p38MAPK‐mediated senescence and SASP. CSE cotreatment with simvastatin and rosuvastatin significantly reduced p38MAPK activation, senescence (decrease in SA‐β‐Gal) and SASP markers, GM‐CSF, and TNF, but not IL‐8, while increasing anti‐inflammatory IL‐10 in a dose‐dependent manner. Cotreatment of CSE and progesterone had no effect on reducing p38MAPK activation, senescence, or SASP.ConclusionBoth simvastatin and rosuvastatin downregulated OS‐induced p38MAPK activation, senescence, and SASP, while rosuvastatin showed a pronounced effect. Progesterone did not reduce OS‐induced fetal membrane senescence and SASP. Simvastatin or rosuvastatin may reduce the incidences of OS‐associated PTB and pPROM by preventing premature senescence and SASP.
“Putting Band‐Aids on Things That Need Stitches”: Immigration and the Landscape of Care in Rural America
Authors: Sangaramoorthy Thurka 
Published: June 2018

ABSTRACTGrowing numbers of immigrants work and live in rural, geographically isolated areas throughout the United States, places without previously settled immigrant populations. Rapid immigration to such areas already struggling with poverty, weak public infrastructures, and high concentrations of uninsured residents has given way to an increasingly precarious landscape of care. The neoliberal logics of American health care and contentious debates over immigration reform shape this landscape and condition relations among providers, immigrants, and others. Through what I call “band‐aid” care and the informal transactions that characterize it, such as rationing, bartering, hoarding, willful noncompliance, and goodwill, providers and immigrants counter these logics of exclusion and inequality by participating in the dynamic improvisation of care considered illicit and often prohibited under the market‐based economic rationale of health‐care provision. Social obligations and moral legitimacy benefit otherwise marginalized providers who engage in this landscape of care, while vulnerable immigrants gain entry and access to vital resources within this landscape through sociality and interdependence, which engender opportunities (however fraught) for living. Yet providers and immigrants understand band‐aid care to be necessary, just, moral, and legitimate in response to precarity characterized by geographical isolation, economic scarcity, civic inequality, market‐based health care, and exclusionary policies. [immigration, health care, exclusion, social inequality, United States]
Hegemonic Concepts of Culture: The Checkered History of Dark Anthropology
Authors: Rodseth Lars 
Published: June 2018

ABSTRACTThis article traces a genealogy of the culture concept, starting with the way it is presented in Sherry Ortner's account of “dark anthropology” (2016) and working back to the interpretations offered by Clifford Geertz, Raymond Williams, and Antonio Gramsci. Of particular interest is the shifting historical relationship between “culture” and its dark counterpart, “hegemony,” which Ortner describes as “the dominant version of the culture concept in use today.” While Ortner's analysis is compelling in many ways, it is flawed, in my view, by a “Boasian gap”—part of a widespread tendency in contemporary anthropology to underestimate the theoretical legacy of Franz Boas and the tradition that bears his name. This tendency is rooted, I argue, in a series of “asymmetrical ancestries.” Thus, Geertz minimized the importance of the Boasian tradition in his own intellectual genealogy, and Williams recognized but downplayed the role of German Romanticism in the early development of the culture concept. The case of Gramsci is especially interesting as it involves a cryptic ancestral connection between his approach to culture and that of his Boasian contemporaries. When all these gaps are filled, dark anthropology turns out to be historically checkered—regularly articulated with a “lighter” theoretical tradition. By recovering that tradition and appreciating its rich genealogy—sensing its manifold connections to German historicism, Humboldtian linguistics, and American pragmatism—we stand a chance of integrating “dark” and “light” anthropologies rather than pitting them needlessly against each other. [culture, genealogy, hegemony, Gramsci, Boas]
Size and modality effects in Braille learning: Implications for the blind child from pre‐reading sighted children
Authors: Barlow‐Brown Fiona , Barker Christopher , Harris Margaret 
Published: June 2018

BackgroundBeginning readers are typically introduced to enlarged print, and the size of this print decreases as readers become more fluent. In comparison, beginning blind readers are expected to learn standard‐sized Braille from the outset because past research suggests letter knowledge cannot be transferred across different sizes of Braille.AimsThe study aims to investigate whether learning Braille using an oversized pegboard leads to faster, transferable, letter learning and whether performance is mediated by either tactile or visual learning.SampleSixty‐eight children participated in the study. All children were sighted pre‐readers with no previous knowledge of Braille. The children came from two nursery schools with an average age of 47.8 months.MethodsChildren were taught specific Braille letters using either an enlarged pegboard or standard Braille. Two other groups of children were taught using visually presented Braille characters in either an enlarged or standard size and a further control group mirrored the experience of blind children in receiving non‐specific tactile training prior to being introduced to Braille. In all tactile conditions it was ensured that the children did not visually experience any Braille for the duration of the study.ResultsResults demonstrated that initially training children with large Braille tactually led to the best subsequent learning of standard Braille. Despite the fact that both initial visual and large tactual learning were significantly faster than learning standard Braille, when transferring letter knowledge to standard tactile Braille, previous tactile experience with the large pegboard offered the most efficient route.ConclusionsBraille letter knowledge can be transferred across size and modality particularly effectively with large tactile Braille. This has significant implications for the education of blind children.
Impact of tocilizumab administered intravenously or subcutaneously on patient-reported quality-of-life outcomes in patients with rheumatoid arthritis
Authors: Strand Vibeke , Michalska Margaret , Birchwood Christine , Pei Jinglan , Tuckwell Katie , Finch Rebecca , Kivitz Alan J , Smolen Josef S , Burmester Gerd R 
Published: June 2018

ObjectiveRandomised controlled trials (RCTs) have shown tocilizumab (TCZ) administered intravenously or subcutaneously with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) to be superior to csDMARDs alone for improving rheumatoid arthritis (RA) disease activity. This study evaluated the effect of TCZ-intravenous and TCZ-subcutaneous on patient-reported outcomes (PROs) in three RCT populations.MethodsOPTION (NCT00106548), BREVACTA (NCT01232569) and SUMMACTA (NCT01194414) were independent RCTs evaluating the efficacy and safety of TCZ-intravenous and/or TCZ-subcutaneous with csDMARDs in patients with RA. PROs included patient global assessment, pain, Health Assessment Questionnaire-Disability Index, Functional Assessment of Chronic Illness Therapy-Fatigue and Short Form-36. Study outcomes included the proportions of patients reporting changes from baseline in PRO scores ≥ minimum clinically important differences (MCID) and scores ≥ age and gender-matched normative values.ResultsIn OPTION, more patients who received TCZ-intravenous reported improvements in PROs ≥MCID (50%–82% vs 31%–57%) and scores ≥ normative values (16%–44% vs 5%–28%) at week 16 compared with placebo. Similarly, a greater proportion of patients in BREVACTA who received TCZ-subcutaneous reported improvements ≥ MCID (54%–73% vs 42%–55%) and scores ≥ normative values (8%–34% vs 4%–25%) at week 12 compared with placebo. In SUMMACTA, 61%–84% of patients who received TCZ-subcutaneous and 64%–84% of those who received TCZ-intravenous reported improvements ≥ MCID and 14%–41% and 15%–24%, respectively, scores ≥ normative values at week 24.ConclusionsTCZ-intravenous or TCZ-subcutaneous with csDMARDs resulted in more patients reporting clinically meaningful improvements and PRO scores ≥ normative values compared with placebo. These improvements were similar with TCZ-intravenous and TCZ-subcutaneous.
CoveringLSH
Authors: Pagh Rasmus 
Published: June 2018

We consider a new construction of locality-sensitive hash functions for Hamming space that is
covering
in the sense that is it guaranteed to produce a collision for every pair of vectors within a given radius
r
. The construction is
efficient
in the sense that the expected number of hash collisions between vectors at distance
cr
, for a given
c
>1, comes close to that of the best possible data independent LSH without the covering guarantee, namely, the seminal LSH construction of Indyk and Motwani (STOC’98). The efficiency of the new construction essentially
matches
their bound when the search radius is not too large—e.g., when
cr
=
o
(log (
n
)/ log log
n
), where
n
is the number of points in the dataset, and when
cr
= log (
n
)/
k
, where
k
is an integer constant. In general, it differs by at most a factor ln (4) in the exponent of the time bounds. As a consequence, LSH-based similarity search in Hamming space can avoid the problem of false negatives at little or no cost in efficiency.
Enhanced Cancer Immunotherapy with Smad3-Silenced NK-92 Cells
Authors: Wang Qing-Ming , Tang Patrick Ming-Kuen , Lian Guang-Yu , Li Chunjie , Li Jinhong , Huang Xiao-Ru , To Ka-Fai , Lan Hui-Yao 
Published: June 2018

AbstractNatural killer (NK) cells, early effectors in anticancer immunity, are paralyzed by TGFβ1, an immunosuppressive cytokine produced by cancer cells. Development and activity of NK cells are largely inhibited in the Smad3-dependent tumor microenvironment. Here, we used genetic engineering to generate a stable SMAD3-silencing human NK cell line, NK-92-S3KD, whose cancer-killing activity and cytokine production were significantly enhanced under TGFβ1-rich condition compared with the parental cell line. Interestingly, we identified that the IFNG gene is a direct E4BP4 target gene. Thus, silencing of SMAD3 allows upregulation of E4BP4 that subsequently promoting interferon-γ (IFNγ) production in the NK-92-S3KD cells. More importantly, NK-92-S3KD immunotherapy increases the production of not only IFNγ, but also granzyme B and perforin in tumors; therefore, inhibiting cancer progression in two xenograft mouse models with human hepatoma (HepG2) and melanoma (A375). Thus, the NK-92-S3KD cell line may be useful for the clinical immunotherapy of cancer. Cancer Immunol Res; 6(8); 965–77. ©2018 AACR.
Growth and nutritional value of Moina macrocopa (Straus, 1820) fed with Saccharomyces cerevisiae and Phaffia rhodozyma
Authors: Manklinniam Piyapan , Chittapun Supenya , Maiphae Supiyanit 
Published: June 2018

Abstract
The nutritional value, astaxanthin level and population growth of Moina macrocopa fed with Chlorella sp., Saccharomyces cerevisiae and Phaffia rhodozyma in eight treatments (C1: 1 × 105 cells/ml; C2: 1 × 106 cells/ml; S1: 4 × 106 cells/ml; S2: 4 × 107 cells/ml; P1: 4 × 107 cells/ml; P2: 4 × 108 cells/ml; SP1: S + P 4 × 106 : 4 × 107 cells/ml; and SP2: S + P 4 × 106 : 4 × 108 cells/ml) were examined. The results showed that lipid content was significantly different among the treatments but protein and carbohydrate were not. C2 had the highest lipid content (11.83 ± 0.87%) whereas C1 and SP1 had the highest protein (76.26 ± 2.84%) and carbohydrate (14.56 ± 3.04%), respectively. In addition, SP1 had the highest astaxanthin level (0.83 ± 0.19 μg/g) and S1 showed fastest population growth rate (0.81 day−1). This indicated that feeding on S. cerevisiae resulted in high lipid and astaxanthin levels and a concentration of 4 × 106 cells/ml enhanced the population growth of M. macrocopa. Therefore, it could replace or be used as supplementary to Chlorella sp. for cladoceran production in mass cultures.
The Spirit of the Letter: The Hebrew Inscription in Bermejo’s Piedat Revisited
Authors: Glazer-Eytan Yonatan 
Published: June 2018

Abstract
The Hebrew inscription in the Piedat attributed to Bartolomé Bermejo is usually viewed in relation to the possible involvement of conversos in the painting. Offering a broader exploration of the local setting as well as the visual and textual models available to Bermejo, this article goes beyond a narrow converso interpretation and situates the inscription within two different contexts: an environment of growing Christian interest in Hebraic knowledge and an Aragonese artistic experimentation with the iconography of the Man of Sorrows.
Connexin 26 Immunohistochemistry in Temporal Bones With Cochlear Otosclerosis
Authors: Miller Mia E. , Lopez Ivan A. , Linthicum Fred H. , Ishiyama Akira 
Published: June 2018

Hypothesis: Connexin-26 (Cx26) expression is diminished in the spiral ligament of subjects with hearing loss and cochlear otosclerosis (CO). Background: Human temporal bone (HTB) studies have demonstrated that CO is associated with hyalinization of the spiral ligament. We hypothesize that hyalinization is associated with a loss of fibrocytes with a consequent decline in Cx26 expression. Cx26 and Connexin-30 (Cx30) encode gap junction proteins expressed in supporting cells of the organ of Corti, the spiral limbus, stria vascularis, and in fibrocytes of the spiral ligament. These gap junctions are critical for potassium recycling and maintenance of the endocochlear potential. Diminished expression of these proteins would likely be associated with hearing dysfunction. Methods: Histopathology and clinical characteristics of 45 HTB specimens with CO and spiral ligament hyalinization were reviewed. Those with sensorineural or mixed hearing loss but normal or near-normal hair cell counts were analyzed with light microscopy, and Cx26-immunoreactive (IR) signal was qualitatively assessed. Results: H&E staining demonstrated hyalinization in the spiral ligament and loss of type II and type III fibrocytes. Cx26-IR was diminished throughout the cochlea affected with CO compared with normal controls. Conclusions: Cx26-IR reduction in the spiral ligament of subjects with CO likely plays a role in hearing loss.
Attention control comparisons with SLT for people with aphasia following stroke: methodological concerns raised following a systematic review
Authors: Brady Marian C , Godwin Jon , Kelly Helen , Enderby Pam , Elders Andrew , Campbell Pauline 
Published: June 2018

Objective: Attention control comparisons in trials of stroke rehabilitation require care to minimize the risk of comparison choice bias. We compared the similarities and differences in SLT and social support control interventions for people with aphasia. Data sources: Trial data from the 2016 Cochrane systematic review of SLT for aphasia after stroke Methods: Direct and indirect comparisons between SLT, social support and no therapy controls. We double-data extracted intervention details using the template for intervention description and replication. Standardized mean differences and risk ratios (95% confidence intervals (CIs)) were calculated. Results: Seven trials compared SLT with social support ( n  =  447). Interventions were matched in format, frequency, intensity, duration and dose. Procedures and materials were often shared across interventions. Social support providers received specialist training and support. Targeted language rehabilitation was only described in therapy interventions. Higher drop-out ( P  =  0.005, odds ratio (OR) 0.51, 95% CI 0.32–0.81) and non-adherence to social support interventions ( P  <  0.00001, OR 0.18, 95% CI 0.09–0.37) indicated an imbalance in completion rates increasing the risk of control comparison bias. Conclusion: Distinctions between social support and therapy interventions were eroded. Theoretically based language rehabilitation was the remaining difference in therapy interventions. Social support is an important adjunct to formal language rehabilitation. Therapists should continue to enable those close to the person with aphasia to provide tailored communication support, functional language stimulation and opportunities to apply rehabilitation gains. Systematic group differences in completion rates is a design-related risk of bias in outcomes observed.
Combining tumor size and diffusion-weighted imaging to diagnose normal-sized metastatic pelvic lymph nodes in cervical cancers
Authors: Song Jiacheng , Hu Qiming , Huang Junwen , Ma Zhanlong , Chen Ting 
Published: June 2018

Background Detecting normal-sized metastatic pelvic lymph nodes (LNs) in cervical cancers, although difficult, is of vital importance. Purpose To investigate the value of diffusion-weighted-imaging (DWI), tumor size, and LN shape in predicting metastases in normal-sized pelvic LNs in cervical cancers. Material and Methods Pathology confirmed cervical cancer patients with complete magnetic resonance imaging (MRI) were documented from 2011 to 2016. A total of 121 cervical cancer patients showed small pelvic LNs (<5 mm) and 92 showed normal-sized (5–10 mm) pelvic LNs (39 patients with 55 nodes that were histologically metastatic, 53 patients with 71 nodes that were histologically benign). Preoperative clinical and MRI variables were analyzed and compared between the metastatic and benign groups. Results LN apparent diffusion coefficient (ADC) values and short-to-long axis ratios were not significantly different between metastatic and benign normal-sized LNs (0.98 ± 0.15 × 10−3 vs. 1.00 ± 0.18 × 10−3 mm2/s, P = 0.45; 0.65 ± 0.16 vs. 0.64 ± 0.16, P = 0.60, respectively). Tumor ADC value of the metastatic LNs was significantly lower than the benign LNs (0.98 ± 0.12 × 10−3 vs. 1.07 ± 0.21 × 10−3 mm2/s, P = 0.01). Tumor size (height) was significantly higher in the metastatic LN group (27.59 ± 9.18 mm vs. 21.36 ± 10.40 mm, P < 0.00). Spiculated border rate was higher in the metastatic LN group (9 [16.4%] vs. 3 [4.2%], P = 0.03). Tumor (height) combined with tumor ADC value showed the highest area under the curve of 0.702 ( P < 0.00) in detecting metastatic pelvic nodes, with a sensitivity of 59.1% and specificity of 78.8%. Conclusions Tumor DWI combined with tumor height were superior to LN DWI and shape in predicting the metastatic state of normal-sized pelvic LNs in cervical cancer patients.