bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of a 320-degree intrastromal corneal ring segment implantation for keratoconus: Results of a 6-month follow-up
Authors: Rocha Guilherme Andrade do Nascimento , Ferrara de Almeida Cunha Paulo , Torquetti Costa Leonardo , Barbosa de Sousa Luciene 
Published: December 2018

Importance: This study shows that a newer long-arc length intrastromal corneal ring segment is efficient and safe for keratoconus treatment. Background: To evaluate visual, tomographic results and complications of a 320-degree intrastromal corneal ring segment implantation with the femtosecond laser for keratoconus treatment. Design: A prospective, nonrandomized, and interventional study. Participants: A total of 34 eyes of 31 patients diagnosed with keratoconus were enrolled. Methods: Patients were divided into two groups based on the strategy used for 320-degree intrastromal corneal ring segment thickness selection. In one group, this selection was based on spherical equivalent (SE group) and in the other on the mean asphericity (Q group). The uncorrected and corrected distance visual acuities, spherical equivalent, K1, K2, Km, Kmax, and mean asphericity ( Q) on corneal tomography were evaluated preoperatively and at 3 and 6 months postoperatively. For astigmatism improvement, we analyzed the corneal tomographic vectorial astigmatism change preoperatively and at 6 months postoperatively. The mean follow-up period was 6.63 ± 0.96 months. Results: The mean uncorrected distance visual acuity and corrected distance visual acuity improved with a significant spherical equivalent improvement ( p < 0.05), with no differences between the 320-degree intrastromal corneal ring segment groups. All corneal tomographic parameters improved significantly ( p < 0.05) between the preoperative and postoperative intervals, with a significant better performance when we used spherical equivalent for the 320-degree intrastromal corneal ring segment thickness selection. Finally, the mean vectorial corneal tomographic astigmatism significantly improved after 6 months, again with no differences between groups. Conclusion: This study suggests that implanting a 320-degree intrastromal corneal ring segment is a safe and effective procedure for treating patients with keratoconus. It also suggests that for thickness selection spherical equivalent is the better strategy.
A bilingual emotional advantage? An investigation into the effects of psychological factors in emotion perception in Arabic and in English of Arabic-English bilinguals and Arabic/English monolinguals
Authors: Alqarni Nada , Dewaele Jean-Marc 
Published: December 2018

Aims and objectives: While the debate on the cognitive bilingual advantage is ongoing, much less attention has been paid to the potential emotional advantage of bilinguals. The present study compared the performance of bilinguals and monolinguals in emotion perception (EP) in Arabic and in English and the differences in trait emotional intelligence (Trait EI). It also considered the relationship between Trait EI and EP scores. Methodology: 205 Arabic-English bilinguals, 71 Arabic monolinguals and 333 English monolinguals had to recognise anger, fear, sadness, disgust, surprise and happiness in 12 short audio-visual video clips (six in English and six in Arabic) embedded in an online questionnaire. The clips contained short conversations about day-to-day situations. Data and analysis: Nonparametric statistical analyses were used to explore the differences between bilinguals and monolinguals in EP in English and Arabic and to explore the relationship between Trait EI and EP. Findings: Bilinguals outperformed English monolinguals in the EP task in English but did not perform better than Arabic monolinguals in Arabic. Bilinguals scored higher on Trait EI than monolinguals, and Trait EI scores were significantly and positively correlated with EP scores. Originality: This study suggests that there is a small bilingual advantage for emotional and psychological domains. Significance: Bilingualism seems to have an effect on some personality dimensions and emotional skills.
A National Survey of Transplant Surgeons and Nephrologists on Implementing Apolipoprotein L1 (APOL1) Genetic Testing Into Clinical Practice
Authors: Gordon Elisa J. , Wicklund Catherine , Lee Jungwha , Sharp Richard R. , Friedewald John 
Published: December 2018

Introduction: There is debate over whether Apolipoprotein L1 (APOL1) gene risk variants contribute to African American (AA) live donors’ (LD) increased risk of kidney failure. Little is known about factors influencing physicians’ integration of APOL1 genetic testing of AA LDs into donor evaluation. Design: We conducted a cross-sectional survey, informed by Roger’s Diffusion of Innovations theory, among nephrology and surgeon members of the American Society of Nephrology, American Society of Transplantation, and American Society of Transplant Surgeons about their practices of and attitudes about APOL1 genetic testing of AA potential LDs. Descriptive statistics and bivariate analyses were performed. Results: Of 383 completed surveys, most physicians believed that APOL1 testing can help AA LDs make more informed donation decisions (87%), and the addition of APOL1 testing offers better clinical information about AA LD’s eligibility for donation than existing evaluation approaches (74%). Among respondents who evaluate LDs (n = 345), 63% would definitely or probably begin or continue using APOL1 testing in the next year, however, few use APOL1 testing routinely (4%) or on a case-by-case basis (14%). Most did not know the right clinical scenario to order APOL1 testing (59%), but would use educational materials to counsel AA LDs about APOL1 testing (97%). Discussion: Although physicians were highly supportive of APOL1 genetic testing for AA LDs, few physicians use APOL1 testing. As more physicians intend to use APOL1 testing, an ethical framework and clinical decision support are needed presently to assist clinicians in clarifying the proper indication of APOL1 genetic testing.
Outcomes and Return to Sport After Pectoralis Major Tendon Repair: A Systematic Review
Authors: Yu James , Zhang Cindy , Horner Nolan , Ayeni Olufemi R. , Leroux Timothy , Alolabi Bashar , Khan Moin 
Published: December 2018

Context: Pectoralis major tendon ruptures are becoming increasingly common due to the growing prevalence of active lifestyles. Studies investigating the efficacy of pectoralis major tendon repair have limited sample sizes and offer mixed results, while existing reviews do not explore postoperative activity outcomes for patients. Objective: To summarize and synthesize the clinical outcomes and rate of return to activity after isolated pectoralis major tendon repair. Data Sources: Four databases (MEDLINE, EMBASE, PubMed, and CINAHL) were searched from database inception through March 7, 2018. Study Selection: Studies reporting outcomes of isolated pectoralis major tendon repair for pectoralis major tendon rupture were included. Study Design: Systematic review. Level of Evidence: Level 4. Data Extraction: Data including patient demographics, intervention details, and clinical outcomes were extracted. The methodological quality of included studies was evaluated. Results: Of 2332 retrieved articles, 18 studies were included, with a total of 536 patients. A majority (90%; 134/149) of patients undergoing pectoralis major tendon repair successfully returned to sport at a mean 6.1 ± 1.7 months postsurgery, of which 74% (95/128) successfully returned to their preinjury level of sport. The majority (95%; 269/284) of patients returned to work at a mean 6.9 ± 1 months. Postsurgically, 81% (83/102) of patients experienced complete pain relief after the surgery, and 19% (21/109) had cosmetic complaints after pectoralis major repair. Of the 10 studies that reported complications, 18% (75/423) of patients had postoperative complications, including reruptures and wound infections; 7% (30/423) of patients required reoperation for their complications. Conclusion: Pectoralis major tendon repair is an effective treatment that results in a high rate of return to sport and work, pain relief, and improved cosmetic appearance, albeit with a significant rate of complication. The evidence supporting all outcomes was limited by the rarity of the injury, the variable surgical techniques, and outcome assessment criteria.
Postoperative Spine Infection: Diagnosis and Management
Authors: Dowdell James , Brochin Robert , Kim Jun , Overley Samuel , Oren Jonathan , Freedman Brett , Cho Samuel 
Published: December 2018

Study Design: Review article. Objectives: A review of the literature on postoperative spinal infections, their diagnosis, and management. Methods: A systematic computerized Medline literature search was performed using PubMed, Cochrane Database of Systematic Reviews, and EMBASE. The electronic databases were searched for publication dates from the last 10 years. The searches were performed from Medical Subject Headings (MeSH) used by the National Library of Medicine. Specifically, MeSH terms “spine,” “infections,” “management,” and “diagnosis” were used. Results: Currently, the gold standard for diagnosis of postoperative spine infection is positive deep wound culture. Many of the current radiologic and laboratory tests can assist with the initial diagnosis and monitoring treatment response. Currently erythrocyte sedimentation rate, C-reactive protein, computed tomography scan, and magnetic resonance imaging with and without contrast are used in combination to establish diagnosis. Management of postoperative spine infection involves thorough surgical debridement and targeted antibiotic therapy. Conclusions: Postoperative spine infection is a not uncommon complication following surgery that may have devastating consequences for a patient’s short- and long-term health. A high index of suspicion is needed to make an early diagnosis.
Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives
Authors: Humbert Marc , Guignabert Christophe , Bonnet Sébastien , Dorfmüller Peter , Klinger James R. , Nicolls Mark R. , Olschewski Andrea J. , Pullamsetti Soni S. , Schermuly Ralph T. , Stenmark Kurt R. , Rabinovitch Marlene 
Published: December 2018

Clinical and translational research has played a major role in advancing our understanding of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms of PH with severe vascular remodelling (e.g. chronic thromboembolic PH and pulmonary veno-occlusive disease). However, PH remains an incurable condition with a high mortality rate, underscoring the need for a better transfer of novel scientific knowledge into healthcare interventions. Herein, we review recent findings in pathology (with the questioning of the strict morphological categorisation of various forms of PH into pre- or post-capillary involvement of pulmonary vessels) and cellular mechanisms contributing to the onset and progression of pulmonary vascular remodelling associated with various forms of PH. We also discuss ways to improve management and to support and optimise drug development in this research field.
Haemodynamic definitions and updated clinical classification of pulmonary hypertension
Authors: Simonneau Gérald , Montani David , Celermajer David S. , Denton Christopher P. , Gatzoulis Michael A. , Krowka Michael , Williams Paul G. , Souza Rogerio 
Published: December 2018

Since the 1st World Symposium on Pulmonary Hypertension (WSPH) in 1973, pulmonary hypertension (PH) has been arbitrarily defined as mean pulmonary arterial pressure (mPAP) ≥25 mmHg at rest, measured by right heart catheterisation. Recent data from normal subjects has shown that normal mPAP was 14.0±3.3 mmHg. Two standard deviations above this mean value would suggest mPAP >20 mmHg as above the upper limit of normal (above the 97.5th percentile). This definition is no longer arbitrary, but based on a scientific approach. However, this abnormal elevation of mPAP is not sufficient to define pulmonary vascular disease as it can be due to an increase in cardiac output or pulmonary arterial wedge pressure. Thus, this 6th WSPH Task Force proposes to include pulmonary vascular resistance ≥3 Wood Units in the definition of all forms of pre-capillary PH associated with mPAP >20 mmHg. Prospective trials are required to determine whether this PH population might benefit from specific management.Regarding clinical classification, the main Task Force changes were the inclusion in group 1 of a subgroup “pulmonary arterial hypertension (PAH) long-term responders to calcium channel blockers”, due to the specific prognostic and management of these patients, and a subgroup “PAH with overt features of venous/capillaries (pulmonary veno-occlusive disease/pulmonary capillary haemangiomatosis) involvement”, due to evidence suggesting a continuum between arterial, capillary and vein involvement in PAH.
Factors targeting MED12 to drive tumorigenesis?
Authors: Bullerdiek Jörn , Rommel Birgit 
Published: December 2018

Mediator Complex Subunit 12 (MED12) is part of the transcriptional preinitiation machinery. Mutations of its gene predominantly occur in two types of highly frequent benign tumors, uterine leiomyomas and fibroadenomas of the breast, where they apparently act as driver mutations. Nevertheless, their presence is not restricted to benign tumors having been found at considerable frequencies in uterine leiomyosarcomas, malignant phyllodes tumors, and chronic lymphocytic leukemia also. Most of the mutations are located within exon 2 of the gene but in rare cases the intron 1/exon 2 boundary or exon 1 are affected. As to their type, predominantly single nucleotide exchanges with a hotspot in one codon are found, but small deletions clustering around that hotspot also are not uncommon. These latter deletions are leaving the open reading frame intact. As to the types of mutations, so far no apparent differences between the tumor entities affected have emerged. Interestingly, this pattern with small deletions clustered around the hotspot of single nucleotide exchanges resembles that seen as a result of targeted gene editing. In contrast to other driver mutations the percentage of MED12-mutation positive tumors of independent clonal origin increases with the number of tumors per patient suggesting unknown etiological factors supporting site specific mutagenesis. These factors may act by inducing simultaneous site-specific double strand breaks the erroneous repair of which may lead to corresponding mutations. As inducers of DNA damage and its repair such as foreign nucleic acids of the microbiome displaying sequence homology to the putative target site might play a role. Interestingly, a 16 base pair homology of the hotspot to a putative terminator base-paired hairpin sequence of a Staphylococcus aureus tRNA gene cluster has been noted which might form R-loop like structures with its target sequence thus inducing said changes.
Caring Revolutionary Transformation: Combined Effects of a Universal Basic Income and a Public Model of Care
Authors: Uhde Zuzana 
Published: December 2018

AbstractThis paper explores the possibilities of the recognition and valuation of care by implementing an unconditional basic income (UBI) and presents a feminist redefinition of the concept of a UBI. The author proposes the notion of acaring revolutionary transformationas a process of institutionalising the social and economic conditions for recognition of care which is a cornerstone of struggles for women’s emancipation and gender equity. It is a process of practically realisable transformative steps which together with their combined and mutually reinforcing effects enable more radical social changes beyond a mere reform. The author argues that these transformative steps have to address two conditions embedded in the institutionalised structures of late modern capitalist society: the limited understanding of meaningful work as paid employment; and the liberal ideal of the independent and autonomous individual. Whereas a UBI can challenge the first condition, a public model of care questions the second condition by shifting the primary responsibility of care from the family towards a social solidarity. While insufficient when introduced separately, the combination of these two remedies has the potential to radically alter social structures on which gendered inequalities rest.
Decomposition of Vehicle Exhaust on Pavement with Nanotitanium Oxide and Promoting Function of Pyroelectric Materials
Authors: Li Feng , Zhou Siqi , Fu Kangyu , Yu Jing , Du Yuchuan , Zhou Peiting , Cheng Zhihao , Yang Zhenglong 
Published: December 2018

Abstract
According to the actual road conditions, the representative temperature, ultraviolet light intensity, and exhaust concentration were selected as the test environment. A study of the law of vehicle exhaust decomposition under different levels was conducted, and the phenomenon of temperature-light equivalence during a catalytic process was proposed. The decomposition products of exhaust gas from nanotitanium dioxide were detected by chemical analysis, and relevant information was obtained through the reaction process. Besides this, the effects of a piezoelectric system and pyroelectric materials on the catalytic efficiency of nanotitanium dioxide were also investigated. Meanwhile, the influence of pyroelectric materials on the catalytic activity of nanotitanium dioxide in different environments was also evaluated. With the increase of load, loading frequency, and temperature, the effect of tourmaline powder on the decomposition of vehicle exhaust gas is improved, and the influence of load and temperature was more obvious than that of the frequency.
The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels
Authors: Arcas José Miguel , González Alejandro , Gers-Barlag Katharina , González-González Omar , Bech Federico , Demirkhanyan Lusine , Zakharian Eleonora , Belmonte Carlos , Gomis Ana , Viana Félix 
Published: December 2018

TRPM8 is a polymodal, nonselective cation channel activated by cold temperature and cooling agents that plays a critical role in the detection of environmental cold. We found that TRPM8 is a pharmacological target of tacrolimus (FK506), a macrolide immunosuppressant with several clinical uses, including the treatment of organ rejection following transplants, treatment of atopic dermatitis, and dry eye disease. Tacrolimus is an inhibitor of the phosphatase calcineurin, an action shared with cyclosporine. Tacrolimus activates TRPM8 channels in different species, including humans, and sensitizes their response to cold temperature by inducing a leftward shift in the voltage-dependent activation curve. The effects of tacrolimus on purified TRPM8 in lipid bilayers demonstrates conclusively that it has a direct gating effect. Moreover, the lack of effect of cyclosporine rules out the canonical signaling pathway involving the phosphatase calcineurin. Menthol (TRPM8-Y745H)- and icilin (TRPM8-N799A)-insensitive mutants were also activated by tacrolimus, suggesting a different binding site. In cultured mouse DRG neurons, tacrolimus evokes an increase in intracellular calcium almost exclusively in cold-sensitive neurons, and these responses were drastically blunted inTrpm8 KOmice or after the application of TRPM8 antagonists. Cutaneous and corneal cold thermoreceptor endings are also activated by tacrolimus, and tacrolimus solutions trigger blinking and cold-evoked behaviors. Together, our results identify TRPM8 channels in sensory neurons as molecular targets of the immunosuppressant tacrolimus. The actions of tacrolimus on TRPM8 resemble those of menthol but likely involve interactions with other channel residues.SIGNIFICANCE STATEMENTTRPM8 is a polymodal TRP channel involved in cold temperature sensing, thermoregulation, and cold pain. TRPM8 is also involved in the pathophysiology of dry eye disease, and TRPM8 activation has antiallodynic and antipruritic effects, making it a prime therapeutic target in several cutaneous and neural diseases. We report the direct agonist effect of tacrolimus, a potent natural immunosuppressant with multiple clinical applications, on TRPM8 activity. This interaction represents a novel neuroimmune interface. The identification of a clinically approved drug with agonist activity on TRPM8 channels could be used experimentally to probe the function of TRPM8 in humans. Our findings may explain some of the sensory and anti-inflammatory effects described for this drug in the skin and the eye surface.
La justicia restaurativa en el Derecho Internacional Público y su relación con la justicia transicional
Authors: Macías Sandoval María Del Refugio , Puente Ochoa Gloria , De Paz González Isaac 
Published: December 2018

La justicia restaurativa es una filosofía y un método para arreglar conflictos que han perturbado la paz, con el fin de restablecerla a través de un proceso en el que intervengan directamente los nvolucrados: víctima, victimario y comunidad. Su aplicación en los conflictos cotidianos con resultados exitosos la ha posicionado en el ámbito internacional y ahora es recomendada en instrumentos de derecho internacional público para alcanzar la armonía perdida por conflictos derivados de hechos considerados delitos de derecho internacional público. Una aplicación específica es en la llamada justicia transicional, como un método para restablecer la paz sin afectar a las víctimas ni favorecer la impunidad, proceso que hoy está viviendo Colombia.
Associations between the dark triad of personality and unspecified/specific forms of Internet-use disorder
Authors: Sindermann Cornelia , Sariyska Rayna , Lachmann Bernd , Brand Matthias , Montag Christian 
Published: December 2018

Background and aims
Despite indications that the dark triad of personality might be associated with Internet-use disorder (IUD), research about these associations is lacking.

Methods
Two studies were performed to grasp the links between these variables. In the first study, a sample consisting of N = 468 participants (n = 130 males) filled in the Short Dark Triad Questionnaire to assess scores in the dark triad of personality and the short Internet Addiction Test to assess tendencies toward unspecified IUD. In the second study, another independent sample of N = 472 participants (n = 143 males) filled in the same questionnaires plus items about specific forms of IUD.

Results
Traits Machiavellianism and psychopathy were positively linked to tendencies toward unspecified IUD in both samples and males and females. Regarding the associations between tendencies toward specific IUDs and the dark triad of personality, no significant associations were found in males (at least not passing correction procedures for multiple testing). In females, trait Machiavellianism/psychopathy and tendencies toward Internet-shopping disorder, trait psychopathy, and tendencies toward Internet-pornography-use disorder as well as trait Machiavellianism and tendencies toward Internet-communication disorder were significantly positively correlated [at least one of the (sub)scales assessing the respective specific IUD was significantly associated with the respective dark triad trait even after correction procedures for multiple testing]. No robust pattern of associations between trait narcissism and unspecified/specific forms of IUD could be observed across (sub)samples.

Discussion and conclusions
These results indicate positive associations of the traits Machiavellianism and psychopathy (on a subclinical level) with tendencies toward IUD, especially unspecified IUD. The associations with tendencies toward specific forms of IUD seem more complex with differential personality correlates for each specific IUD. These associations need to be replicated.