bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel zebrafish model to emulate lung injury by folate deficiency-induced swim bladder defectiveness and protease/antiprotease expression imbalance
Authors: Lee Gang-Hui , Cheng Nai-Wei , Yu Hsin-Hsuan , Tsai Jen-Ning , Liu Tsunglin , Wen Zhi-Hong , Chen Bing-Hung , Fu Tzu-Fun 
Published: September 2019

AbstractLung injury is one of the pathological hallmarks of most respiratory tract diseases including asthma, acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). It involves progressive pulmonary tissue damages which are usually irreversible and incurable. Therefore, strategies to facilitate drug development against lung injury are needed. Here, we characterized the zebrafish folate-deficiency (FD) transgenic line that lacks a fully-developed swim bladder. Whole-mount in-situ hybridization revealed comparable distribution patterns of swim bladder tissue markers between wild-type and FD larvae, suggesting a proper development of swim bladder in early embryonic stages. Unexpectedly, neutrophils infiltration was not observed in the defective swim bladder. Microarray analysis revealed a significant increase and decrease of the transcripts for cathepsin L and a cystatin B (CSTB)-like (zCSTB-like) proteins, respectively, in FD larvae. The distribution of cathepsin L and the zCSTB-like transcripts was spatio-temporally specific in developing wild-type embryos and, in appropriate measure, correlated with their potential roles in maintaining swim bladder integrity. Supplementing with 5-formyltetrahydrofolate successfully prevented the swim bladder anomaly and the imbalanced expression of cathepsin L and the zCSTB-like protein induced by folate deficiency. Injecting the purified recombinant zebrafish zCSTB-like protein alleviated FD-induced swim bladder anomaly. We concluded that the imbalanced expression of cathepsin L and the zCSTB-like protein contributed to the swim bladder malformation induced by FD and suggested the potential application of this transgenic line to model the lung injury and ECM remodeling associated with protease/protease inhibitor imbalance.
Tailoring exciton dynamics of monolayer transition metal dichalcogenides by interfacial electron-phonon coupling
Authors: Nie Zhonghui , Shi Yongliang , Qin Shuchao , Wang Yuhan , Jiang Hongzhu , Zheng Qijing , Cui Yang , Meng Yuze , Song Fengqi , Wang Xiaoyong , Turcu Ion C. E. , Wang Xinran , Xu Yongbing , Shi Yi , Zhao Jin , Zhang Rong , Wang Fengqiu 
Published: September 2019

AbstractWith their strong light-matter interaction and rich photo-physics, two-dimensional (2D) transition metal dichalcogenides (TMDs) are important candidates for novel photonic and spin-valleytronic devices. It is highly desirable to control the photocarrier behaviours of monolayer TMDs to suit the needs of device functionalities. Here, through interfacial engineering, i.e., by depositing monolayer MoSe2 onto different oxide substrates (SiO2, Al2O3 and HfO2), we have revealed large tuning of the exciton relaxation times in monolayer TMDs. Significantly, the non-radiative recombination of MoSe2 is found shortened by almost one order of magnitude, from 160 ± 10 ps (on SiO2) to 20 ± 4 ps (on HfO2). Theoretical simulations based on ab initio non-adiabatic molecular dynamics (NAMD) method, together with temperature-dependent optical spectroscopy, identifies interfacial electron-phonon (e-ph) coupling as the leading mechanism for the lifetime tuning. Our results establish interface engineering as an effective knob for manipulating excited-state dynamics of monolayer TMDs.
Unraveling the thermodynamic conditions for negative gas adsorption in soft porous crystals
Authors: Vanduyfhuys L. , Van Speybroeck V. 
Published: September 2019

AbstractSoft porous crystals (SPCs) are widely known for their intriguing properties and various counterintuitive phenomena such as negative linear compression, negative thermal expansion and negative gas adsorption (NGA). An intriguing case is the adsorption of methane in DUT-49 for which experimentally a drop in the amount of adsorbed particles was observed under increasing vapor pressure. It is yet unknown which specific systems can exhibit NGA under which thermodynamic conditions. Herein, a semi-analytical thermodynamic model is applied to determine the conditions required for NGA, including their sensitivity towards various system-specific parameters, and investigate the correlation with pressure-induced breathing. As such, it is found that certain non-breathing materials may exhibit breathing with NGA under application of a fixed mechanical pressure. Such meticulous control of multiple triggers for NGA can open the way to new applications such as tunable gas detection and pressure amplification.
Ufd1 phosphorylation at serine 229 negatively regulates endoplasmic reticulum-associated degradation by inhibiting the interaction of Ufd1 with VCP
Authors: Nguyen Quynh-Anh Thi , Choi Juyong , Yang Jin Kuk , Lee Sang Yoon 
Published: September 2019

Abstract
Misfolded proteins in the endoplasmic reticulum (ER) are removed through multistep processes termed ER-associated degradation (ERAD). Valosin-containing protein (VCP) plays a crucial role in ERAD as the interaction of ubiquitin fusion degradation protein 1 (Ufd1) with VCP via its SHP box motif (228F-S-G-S-G-N-R-L235) is required for ERAD. However, the mechanisms by which the VCP–Ufd1 interaction is regulated are not well understood. Here, we found that the serine 229 residue located in the Ufd1 SHP box is phosphorylated in vitro and in vivo by cyclic adenosine monophosphate-dependent protein kinase A (PKA), with this process being enhanced by either forskolin (an adenylyl cyclase activator) or calyculin A (a protein phosphatase inhibitor). Moreover, a phosphomimetic mutant (S229D) of Ufd1 as well as treatment by forskolin, calyculin A, or activated PKA strongly reduced Ufd1 binding affinity for VCP. Consistent with this, the Ufd1 S229D mutant significantly inhibited ERAD leading to the accumulation of ERAD substrates such as a tyrosinase mutant (C89R) and 3-hydroxy-3-methylglutaryl coenzyme A reductase. However, a non-phosphorylatable Ufd1 mutant (S229A) retained VCP-binding ability and was less effective in blocking ERAD. Collectively, our results support that Ufd1 S229 phosphorylation status mediated by PKA serves as a key regulatory point for the VCP–Ufd1 interaction and functional ERAD.
A Modified Rotator Cuff Sparing Approach to the Proximal Humerus in Antegrade Nail Osteosynthesis with Transosseous Supraspinatus Tendon Refixation
Authors: Ateschrang Atesch , Gratzer Christoph , Stöckle Ulrich , Schreiner Anna Janine 
Published: September 2019

Abstract
Background Due to the approach within antegrade humerus nail osteosyntheses, lesions of the supraspinatus tendon with a consecutive functional limitation of the rotator cuff (RC), insufficiencies, adhesions and chronic shoulder pain in the long term can result. The evidence respectively the study data situation is limited regarding the evaluation of this issue.
Patients/Material and Methods We are the first to present by means of a case report with a geriatric female patient and a dislocated diaphyseal humerus fracture a rotator cuff sparing osseous approach to the proximal humerus in antegrade nail osteosynthesis without harming the vulnerable supraspinatus tendon (SSP). This is possible through a limited osteotomy of the greater tubercle with the preparation of a 10 mm deep and 15 to 20 mm wide osseous SSP base. The medullary cavity is then opened for inserting the nail in an antegrade manner and closed after fracture stabilization through reposition of the attached osteotomy of the greater tubercle by means of a suture anchor, for example. The procedure also includes a biceps tenodesis. Besides the description of the intraoperative approach and procedure, the clinical and functional results were recorded by established scores as well as radiologically respectively sonographically 6 weeks (T1) and 3 months (T2) postoperatively.
Results The patient was very satisfied regarding pain and function after the modified operative procedure. The rotator cuff tests were negative and there were no impingement like symptoms or indications for an adhesive capsulitis. Range of motion as well as the Constant and (Quick) DASH-Score showed a very good function in the course. The implant was located regularly in the radiological control and the fracture showed a good osseous consolidation. A bland joint without effusion or periarticular fluid and no adhesion with the delta fascia could be presented by sonography. The RC and especially the SSP showed a normal sonographic separation. The functional results are comparable to the other publications so far.
Conclusion The described surgical technique shows a significantly less invasive approach for the implantation of an antegrade humerus nail in the case of a humerus shaft fracture with an excellent function of the affected shoulder in a short-term follow-up. This novel approach should be evaluated by means of prospective studies regarding the functional outcome to justify the establishment of this modified procedure in the long term. Other modified approaches have been depicted but are essentially differing from our described procedure with regards to the invasiveness of the vulnerable tendinous structure of the SSP respectively RC.
Hautzeichen bei rheumatologischen Erkrankungen im Kindes- und Jugendalter
Authors: Vogt Annika , Stieler Karola Maria , Blume-Peytavi Ulrike 
Published: September 2019

ZusammenfassungRheumatologische Erkrankungen können sich in einer großen Vielfalt an der Haut manifestieren. Das Spektrum reicht von flüchtigen Exanthemen bis zu tiefer Sklerosierung, Vaskulitis und Pannikulitis. Dank der Zugänglichkeit für Inspektion, Dermatoskopie, Palpation und Biopsien können dermatologische Mitbeurteilungen wertvolle Hinweise für die diagnostische Einordnung geben. Während bei einigen rheumatologischen Erkrankungen, wie kutanem Lupus erythematodes oder Sklerodermie, spezifische Hautzeichen leicht mit dem Auge zu erkennen oder mit den Fingern zu ertasten sind, sind Hautzeichen wie Exantheme, leukozytoklastische Vaskulitis oder Erythema nodosum klar definierte Entitäten, die jedoch verschiedene Ursachen haben können. Gerade im Kindesalter müssen die häufigen, transienten infektassoziierten Varianten von immunologischen Grunderkrankungen abgegrenzt werden. Die Symptome sind teilweise inkomplett oder atypisch und können weiteren Manifestationen vorausgehen, was interdisziplinäre Verlaufsbeurteilungen erfordert. Die hier vorgestellten Hautzeichen rheumatologischer Erkrankungen im Kindes- und Adoleszentenalter illustrieren den Wert einer engen interdisziplinären Zusammenarbeit.
Sicherheit von Antirheumatika in der Schwangerschaft: Empfehlungen von Embryotox
Authors: Weber-Schoendorfer Corinna 
Published: September 2019

ZusammenfassungDie Innovationen in der Therapie rheumatischer Erkrankungen haben die Lebensqualität vieler PatientInnen deutlich verbessert, sodass mehr Frauen ihren Kinderwunsch planen und realisieren können. In diesem Artikel werden die Erfahrungen zu Antirheumatika in der Schwangerschaft zusammenfassend dargestellt und Empfehlungen für den klinischen Alltag gegeben.Die Beratung zum Arzneimittelrisiko muss 2 verschiedenen Situationen Rechnung tragen: der Einschätzung einer Arzneitherapie bei ungeplanter Schwangerschaft und der geplanten Arzneistoffauswahl bei Kinderwunsch bzw. in der Schwangerschaft. Für eine individuelle Risiko-Nutzen-Einschätzung sind, neben der Vorgeschichte der Patientin, Kenntnisse zum möglichen Risiko und Erfahrungsumfang der Arzneistoffe erforderlich sowie zu Besonderheiten und Verlauf der jeweiligen rheumatischen Erkrankung in der Schwangerschaft. Das Pharmakovigilanz- und Beratungszentrum für Embryonaltoxikologie (PVZ Embryotox) bietet Beratungen zu Arzneimitteln in Schwangerschaft und Stillzeit an und unterstützt die behandelnden ÄrztInnen bei der Therapieauswahl und Risikoeinschätzung.
Endocannabinoidsystem und Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung im Erwachsenenalter
Authors: Brunkhorst-Kanaan Nathalie , Kittel-Schneider Sarah 
Published: September 2019

ZUSAMMENFASSUNGADHS ist eine entwicklungspsychiatrische Erkrankung, die im Erwachsenenalter häufig unerkannt und unbehandelt bleibt. Die Folgen für die Betroffenen sind neben häufigeren Arbeitsplatzverlusten, ein erhöhtes Unfallrisiko und Schwierigkeiten in der sozialen Interaktion. Häufig präsentiert sich die ADHS im Erwachsenenalter sehr heterogen und ist in ca. 80 % der Fälle mit psychiatrischen Komorbiditäten, wie Depressionen, bipolare Störung, Angststörung, Borderline- und dissoziale Persönlichkeitsstörung sowie Suchterkrankungen vergesellschaftet. Letztere führt zu der hohen Inzidenz von Cannabismissbrauch von Patienten mit ADHS. Auf der anderen Seite wird vermutet, dass Cannabis von den Betroffenen als leichtes Sedativum im Sinne einer Selbstmedikation gegen einige Symptome des ADHS wie innere Unruhe, Rastlosigkeit und Schlafstörungen eingesetzt wird. Seit den frühen 1990er-Jahren sind zahlreiche Studien erschienen, die den Zusammenhang zwischen einer Störung des physiologischen endogenen Cannabinoidsystems und der Genese psychiatrischer Erkrankungen wie Depressionen, Angststörungen, posttraumatischer Belastungsstörung (PTBS), Schizophrenie, Suchterkrankungen und Schlafstörungen beschreiben und im Endocannabinoidsystem eine potenzielle Möglichkeit neuer pharmakologischer Behandlungsmöglichkeiten, z. B. durch den Einsatz von synthetischen Cannabinoiden, sehen. In diesem Artikel sollen grundlegende Mechanismen des Endocannabinoidsystems erklärt und die Zusammenhänge mit der Genese des ADHS anhand der Studienlage beleuchtet werden. Zudem soll ein Ausblick auf mögliche Therapieoptionen mit Cannabinoiden gegeben werden.
COPD – Patienten-Simulationsmodell für COPD bietet Vorteile
im Vergleich zu etablierten Markov-Modellen
Authors: Potempa Christoph 
Published: September 2019

Hoogendoorn et al. Broadening the Perspective of Cost-Effectiveness Modeling in
Chronic Obstructive Pulmonary Disease: A New Patient-Level Simulation Model
Suitable to Evaluate Strafified Medicine. Value Health 2019; 22(3): 313–321
Die Autoren um Hoogendoorn et al. präsentieren ein gesundheitsökonomisches
Patienten-Simulationsmodell zur Behandlung von COPD, welches geeignet ist,
die inkrementellen Kosten und Auswirkungen verschiedener Behandlungsoptionen
für diverse Subpopulationen von COPD-Patienten zu bestimmen. Das Modell
liefert damit wertvolle Informationen, die auch zur Entwicklung neuer
Behandlungsmöglichkeiten beitragen können.
Preisfindung – Ausschreibungsverfahren für Impfstoffe
drücken die Preise
Authors: Fietz Cornelia 
Published: September 2019

Qendri V et al. Pricing of HPV vaccines in European tender-based settings. Eur J
Health Econ 2019; 20(2): 271–280
Impfstoffausschreibungen sind eine gängige Methode zur Kostendämpfung teurer
Impfstoffe in der Europäischen Union. Die Autoren untersuchen am Beispiel
der Impfung gegen humane Papillomaviren, wie sich die
Ausschreibungsverfahren in Europa unterscheiden und welche Faktoren die
Preisfindung beeinflussen.
Clinical and Radiologic Evaluation of an Individual with Hypochondroplasia and a Novel FGFR3 Mutation
Authors: Ramos Mejía Rosario , Aza-Carmona Miriam , del Pino Mariana , Heath Karen E. , Fano Virginia , Obregon Maria Gabriela 
Published: September 2019

AbstractHypochondroplasia (HCH), a skeletal dysplasia caused by mutations in the fibroblast growth factor receptor 3 (FGFR3) gene, is characterized by disproportionate short stature. The p.Asn540Lys (p.N540K) mutation accounts for ∼50 to 70% of cases of HCH, but novel FGFR3 mutations are described. We present a family with disproportionately short stature and mild radiologic findings seen in a major public pediatric hospital in Argentina. A previously undescribed heterozygous missense variant in FGFR3, NM_000142.4:667C > T; p.(Arg223Cys) was identified. The predicted phenotype correlates well with the mild auxologic and radiologic characteristics observed. In this case, disproportionately short stature raised the suspicion of skeletal dysplasia.
A descriptive comparative study of the strategies applied for the translation of the vernacular dialect of John
Steinbeck’s Of Mice and Men as a sociolect into Farsi
Authors: Ala Mahsa , Salahshoor Farzad 
Published: September 2019

Abstract
This study aims to identify and compare the strategies applied by native Farsi Translators, Parviz Dariyush (1975) and Soroush Habibi (2009), in
rendering the vernacular dialect (Chicano English) of John Steinbeck’s Of Mice and Men (1965) as a sociolect into
Farsi. One hundred samples which contained seven unique characteristics of vernacular dialect limited to the two main characters
of the novel, George and Lennie, were extracted from the novel with their Farsi equivalents. Sienkiewicz (1984, as cited in Berezowski 1997: 35) proposed
strategies for the translation of dialects are taken as the model for this study to investigate the way dialectal features are
dealt with in the selected parts and to check whether the procedure proposed by Sienkiewicz is sufficient and adequate for their
translation. Analysing these samples, the results showed that one-to-one transference of dialectal elements is not practically
possible into Farsi. However, both translators used phonological, syntactical, and morphological irregularities of Colloquial
Farsi to show that the language of the novel is not standard language. Approximate Variety Substitution is the most frequent
strategy used by Habibi and Dariyush. The aim of this strategy is to select a colloquial variety that has some dialectal features
such as lexical, phonological, and morphological specifics and at the same time does not present an obvious recognizable TL
dialect.
Le tournant sémiotique du début du XXème siècle
Authors: Haßler Gerda 
Published: September 2019

Résumé
Le centenaire de la publication du Cours de linguistique
générale (1916) de Ferdinand de Saussure nous a invité à
reconsidérer l’importance de cet ouvrage et le rôle de son auteur pour la
fondation d’une linguistique intégrée dans une sémiologie. Il n’y a aucun doute
que cet auteur fut extrêmement important pour le développement de la
linguistique structurale en Europe et qu’avec son concept du signe linguistique
il a fait œuvre de pionnier pour le tournant sémiologique. Mais l’accueil
favorable d’une théorie dans le milieu scientifique ne s’explique pas seulement
par sa qualité intérieure, mais par plusieurs conditions extérieures. Ces
conditions seront analysées sur trois plans: (1) l’arrivée de la méthode des
néogrammairiens à ses limites qui incitait alors à l’étude de l’unité du
signifiant et du signifié; (2) la simplification et l’outrance de la pensée
structurale dans le Cours, publié en 1916 par Charles Bally et
Albert Sechehaye et (3) la préparation de la réception de la pensée sémiologique
par plusieurs travaux parallèles.
Shakedown loading capacity prediction of metal-based nanocomposites
Authors: Soleimanian Sina , Chen Min , Tate Derrick , Zhang Shunqi 
Published: September 2019

Abstract
Nano reinforcement of metals cannot escape the attention of designers who seek to improve overall performance of engineering structures from automotive components to biomedical devices. Since many engineering structures are susceptible to variable cyclic load, presenting shakedown design of them is of the present research interest. So that, in the present research the shakedown loading capacity of metal based nanocomposite is estimated through finite element discretization and interior point optimization method. Finally, the results are obtained for plate structures subjected to two independent biaxial loads. A maximum improvement of 71.2% is achieved for shakedown load factor of the structure, which means a remarkable improvement in load bearing capacity of the structure.
Prediction of outlet air temperature of direct air condenser based on BP neural network
Authors: Bai Jianyun , Meng Xinyu , Qu Yan , Feng Geng 
Published: September 2019

Abstract
At present, the dynamic parameter monitoring technology of the direct air cooling system is relatively weak. According to the study of outlet air flow temperature characteristics, this paper proposes a direct air condensing unit outlet air flow temperature prediction model based on BP neural network for studying dynamic parameters of direct air cooling units. The historical data of each factor is collected from the on-site DCS system. After the data is preprocessed, the BP neural network is used to establish the air temperature prediction model of the air condenser. Finally, the model is validated by the data that does not participate in the training. The model can predict the outlet air temperature of the air condenser under different working conditions, providing a basis for the next step of developing dynamic parameter monitoring technology, and also provide a reference for the cleaning cycle of the air condenser.
Performance evaluation of constant hanger for in-service pipelines in power plant
Authors: Wan Yu , Yang Qingxu , Jin Chuanling , Liu Xubi , Yang Xianbiao , Yang Chao 
Published: September 2019

Abstract
Aiming at the in-service pipeline of thermal power plant, considering the impact of pipeline operation factors, the finite element method is used to calculate the static load and modal analysis of the pipeline system, under the method of selecting the constant hanger according to the risk size, the constant hanger with abnormal state is found accurately, realized the evaluation of the whole state of the constant hanger of the pipeline system. The results show that after a long period of operation or vibration, the output load of the constant hanger near the maximum thermal displacement point and the maximum response point of the low order natural frequency will decrease due to the relaxation of the spring, resulting in the deviation of the performance index of the constant hanger, which can still meets the standard requirements after correction by the performance test. It is feasible to evaluate the overall state of the pipeline constanthanger by selecting partial constant hanger, which has some reference value for the safety evaluation of the Steam Pipe branch hanger in power plant.
Design and research on optimization of single point mooring system
Authors: Wang Ying , Xie Haiyan , Zheng Enxi 
Published: September 2019

Abstract
In this paper, we establish a statics model to analyze the force balance of the buoys, four steel pipes and steel buckets, and we derive the relationship between the inclination angle of steel pipes and steel buckets and the draught depth and wind speed, which is solved by moment in mechanics. Next, by applying the catenary curve’s equation to per unit of anchor chain, we can obtain the vertical height of anchor chain, thus the total depth of sea water can be obtained. Finally, the variable step search algorithm is used to search the draught depth, and we can obtain each parameter of the optimization result.