bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term outcomes of Fistula Laser Closure (FiLaC ® ) with a 1470 nm diode laser for cryptoglandular anal fistula
Authors: Zhu Jingyi , Li Zhicheng , Jin Lei , Zhang Xiyue , Wu Jiong , Wang Zhenyi 
Published: November 2024

Abstract

Objective
The aim of this study was to evaluate the long-term efficacy of Fistula Laser Closure (FiLaC®)with using a 1470 nm diode laser in the treatment of cryptoglandular anal fistula.
Methods
Data of patients with cryptoglandular anal fistula who underwent FiLaC® in our department between September 2017 and December 2019 were retrospectively analyzed. Demographic data, perioperative data and postoperative data were collected and statistically analyzed.
Results
A total of 52 patients who met the inclusion criteria were included in the study. The cure rates at 1month, 1 year, and 5 years were 96.2% (50/52), 82.7% (43/52), and 76.9% (40/52), respectively. The differences among the internal opening position subgroups were statistically significant (P = 0.018), with the bilateral type having a higher cure rate than the anterior and posterior types (86.2%, 75% and 37.5%, respectively). No statistically significant differences were observed between the subgroups: Parks classification, number of internal openings, closure of internal openings, treatment of internal openings, number of external openings, relative position of internal and external openings, presence of straight fistula, and presence of blind fistula. All the scores, including visual analogue scale pain score (VAS-PS), cleveland clinic florida incontinence score (CCF-IS), and the quality of life in patients with anal fistula questionnaire score (QoLAF-QS), showed a gradual increase over time, followed by a subsequent decrease.
Discussion
Although the cure rate of the FiLaC® technique is inferior to that of traditional surgery, the FiLaC® technique has significant advantages in reducing the postoperative pain, the risk of fecal incontinence, and the postoperative quality of life. Furthermore, the FiLaC® technique is more suitable for cryptoglandular anal fistulas with an internal opening located on both sides or behind the anal canal. This study provides a preliminary evaluation of the FiLaC® technique, and we hope to increase the cure rate in the future by observing improvements in surgical methods, laser burning power, laser burning time and other aspects.
Stereotactic body radiotherapy (SBRT) as a treatment for localized prostate cancer: a retrospective analysis
Authors: De Cooman Brecht , Debacker Tibaut , Adams Thomas , Lamberts Guy , De Troyer Bart , Claessens Marc , De Kerf Geert , Mercier Carole , Dirix Piet , Ost Piet 
Published: November 2024

Abstract

Background
External beam radiotherapy (EBRT) is a standard treatment for localized prostate cancer, with recent advancements favoring a reduced number of treatment sessions. Stereotactic body radiotherapy (SBRT) is a form of radiotherapy that delivers higher doses per fraction, typically in five or fewer sessions. This retrospective study aims to evaluate the implementation of the PACE-B SBRT protocol for localized prostate cancer at our center by assessing the incidence and severity of toxicity, as well as biochemical relapse-free survival.
Methods
We conducted a retrospective analysis of patients with localized prostate cancer treated with SBRT at the Iridium Network in Antwerp, Belgium, who were treated between January 1, 2020, and December 31, 2022. Data were extracted from electronic medical records and included descriptive information on patient outcomes. Acute and late genitourinary (GU) and gastrointestinal (GI) toxicities were graded according to the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. Acute toxicity was defined as events occurring within 90 days post-SBRT, whereas late toxicity was evaluated at 6 months, 1 year, 2 years, and 3 years post treatment. Biochemical recurrence was defined via the Phoenix criteria, as a rise in PSA levels of 2 ng/mL or more above the post treatment nadir.
Results
A total of 267 patients met the eligibility criteria for this study. In total, 9% of patients were low risk, 51% were intermediate risk, and 40% were high risk. The cumulative incidence of Grade 2 or higher GU toxicity was 27%, and for GI toxicity, it was 2%. At 24 months, 11.5% (20/175) of patients experienced CTCAE grade 2 or higher GU toxicity, and 1.7% (3/175) experienced grade 2 or higher GI toxicity. Biochemical relapse occurred in 1.5% (4/267) of patients, leading to a 3-year biochemical relapse-free survival rate of 98.5%.
Conclusion
SBRT for localized prostate cancer has favorable oncological outcomes with a low incidence of Grade 2 or higher toxicity. The results of this study are consistent with findings from prospective trials, suggesting that SBRT is an effective treatment modality.
Trial registration
Retrospectively registered.
The use of a heated helium-oxygen mixture in patients with severe COVID-19 and ARDS against the background of standard therapy and noninvasive ventilation
Authors: Nuralieva G. S. , Shmidt A. E. , Yaroshetskiy A. I. , Nekludova G. V. , Gaynitdinova V. V. , Tsareva N. A. , Merzhoeva Z. M. , Chikina S. Yu. , Trushenko N. V. , Avdeev I. S. , Avdeev S. N. 
Published: November 2024

Introduction. One of the insufficiently studied methods of Acute Respiratory Distress Syndrome (ARDS) therapy is therapy with a heated helium-oxygen mixture. Due to physico-chemical properties, helium demonstrates high efficiency in the treatment of various diseases of the pulmonological profile.Aim. To study the effect of a heated helium-oxygen mixture on the course of a severe form of COVID-19 occurring with the development of ARDS.Materials and methods. The study involved 58 patients with severe and extremely severe coronavirus infection and ARDS, divided into the NVL + t-He/O2 group (n = 30) and the NVL+O2 control group (n = 28). In addition to standard treatment, patients of the NVL + t-He/O2 group received noninvasive ventilation (NVL) and therapy with a heated helium-oxygen mixture, according to clinical recommendations. In the main group, inhalations took place daily for 60 minutes per day for 5 days.Results. Against the background of therapy with a heated helium-oxygen mixture, a more intense increase in the level of lymphocytes was observed: 1.39 (1.09-1.66) x 109/l in the NVL + t-He/O2 group versus 1.02 (0.78-1.40) x 109/l (p = 0.02). Also, as a result of treatment, there was a significant decrease in RR, D-dimer and CRP in the study group: the level of RR (21 (20-22)/minute versus 22.5 (21-24)/minute, p = 0.003), D-dimer (0.44 (0.29-0.60) FEU ng/ml versus 0.79 (0.42-1.34) FEU ng/ml, p = 0.02) and CRP (1.1 (0.7-3.1)mg/l versus 16.6 (8.5-29.5) mg/l, p = 0.03), respectively. Similarly to the NVL + t-He/O2 group, an increase in the level of PaO2 and the oxygenation index was noted. In addition, there were significantly fewer patients with grade III and IV lung damage in the NVL + t-He/O2 group compared with the control (p = 0.05).Conclusion. The use of a heated helium-oxygen mixture in patients with severe COVID-19, occurring with the development of ARDS, against the background of standard therapy and NIV has shown its safety and effectiveness: there was a decrease in the intensity of inflammation, improved oxygenation and a reduction in the need for respiratory support.
Sensitive HPLC Method to Support Pre-formulation Studies and to Determine Critical Quality Attributes of Therapeutic Contact Lenses Containing Dorzolamide Hydrochloride
Authors: Jani Harshilkumar , Ranch Ketan , Lalwani Rahul , Patel Yashkumar , Bodiwala Kunjan , Gajjar Anuradha 
Published: November 2024

Background:
Dorzolamide hydrochloride (DRZ) is a carbonic anhydrase inhibitor used
to treat glaucoma and ocular hypertension. Drug-eluting contact lenses, such as Acuvue Theravision
™ with Ketotifen, offer improved drug delivery and reduced side effects compared to eye
drops. Drug-loaded nanoparticle-loaded contact lenses can sustain drug release and enhance comfort
for extended wear.

Objective:
High buffer concentration and low pH increase the risk of damage to silica-bonded
columns. Therapeutic contact lenses face challenges related to critical lens parameters, including
the estimation of drug incorporation and release due to interference of lens matrix leaching. There
is currently no analytical method available for estimating DRZ in contact lenses.

Methods:
The HPLC method, which was developed and validated using ICH Q2 (R1) criteria,
used a C18 column (250 mm × 4.6 mm, 5 μm) as a stationary phase and methanol:water (70:30
v/v) as the mobile phase. The detecting wavelength was 253 nm. Moreover, to support the efficiency
of the developed method, the marketed formulation of DRZ eye drops, drug purity, and loading
in contact lenses were analysed. The method was also employed to determine the Critical Quality
Attributes (CQAs) of therapeutic contact lenses and drug release and drug leaching during the sterilization
process.

Results:
The developed HPLC method shows Rt for DRZ at 2.881 minutes with good linearity (r2
> 0.998) between 2-32μg/mL, precision (RSD < 2%), accuracy (Recovery > 99.5%), sensitivity,
and specificity for quantifying DRZ in marketed formulations and therapeutic contact lenses. The
developed method is devoid of any buffer or modifier in the mobile phase, making it safer for the
stationary phase. This method mitigates the interference of lens matrix leaching, which induces an
overestimation of DRZ. All the result for therapeutic contact lenses was found to be closely
aligned with theoretically expected results, confirming the reliability of the developed HPLC
method for therapeutic contact lenses.

Conclusion:
This method is specific, accurate, and precise for quantifying DRZ in commercial formulations
and newly developed therapeutic contact lenses. It effectively evaluates the critical quality
attributes of these lenses, demonstrating their reliability for assessing their performance and ensuring
quality in therapeutic applications.
Influence of Training With Corrective Feedback Devices on Cardiopulmonary Resuscitation Skills Acquisition and Retention: Systematic Review and Meta-Analysis
Authors: Nicolau Abel , Jorge Inês , Vieira-Marques Pedro , Sa-Couto Carla 
Published: November 2024

Background
Several studies related to the use of corrective feedback devices in cardiopulmonary resuscitation training, with different populations, training methodologies, and equipment, present distinct results regarding the influence of this technology.

Objective
This systematic review and meta-analysis aimed to examine the impact of corrective feedback devices in cardiopulmonary resuscitation skills acquisition and retention for laypeople and health care professionals. Training duration was also studied.

Methods
The search was conducted in PubMed, Web of Science, and Scopus from January 2015 to December 2023. Eligible randomized controlled trials compared technology-based training incorporating corrective feedback with standard training. Outcomes of interest were the quality of chest compression–related components. The risk of bias was assessed using the Cochrane tool. A meta-analysis was used to explore the heterogeneity of the selected studies.

Results
In total, 20 studies were included. Overall, it was reported that corrective feedback devices used during training had a positive impact on both skills acquisition and retention. Medium to high heterogeneity was observed.

Conclusions
This systematic review and meta-analysis suggest that corrective feedback devices enhance skills acquisition and retention over time. Considering the medium to high heterogeneity observed, these findings should be interpreted with caution. More standardized, high-quality studies are needed.

Trial Registration
PROSPERO CRD42021240953; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=240953
Navigating Awareness and Strategies to Support Dementia Advocacy on Social Media During World Alzheimer’s Month: Infodemiology Study
Authors: Bacsu Juanita-Dawne , Fraser Sarah Anne , Jamali Ali Akbar , Conanan Christine , Chasteen Alison L , Vellani Shirin , Gowda-Sookochoff Rory , Berger Corinne , Mah Jasmine C , Fehr Florriann , Virani Anila , Rahemi Zahra , Nanson Kate , Cammer Allison , Andrew Melissa K , Grewal Karl S , McGilton Katherine S , Lautrup Samantha , Spiteri Raymond J 
Published: November 2024

Background
Understanding advocacy strategies is essential to improving dementia awareness, reducing stigma, supporting cognitive health promotion, and influencing policy to support people living with dementia. However, there is a dearth of evidence-based research on advocacy strategies used to support dementia awareness.

Objective
This study aimed to use posts from X (formerly known as Twitter) to understand dementia advocacy strategies during World Alzheimer’s Awareness Month in September 2022.

Methods
Posts were scraped from X during World Alzheimer’s Awareness Month from September 1, 2022, to September 30, 2022. After applying filters, 1981 relevant posts were analyzed using thematic analysis, and measures were taken to support trustworthiness and rigor.

Results
Our study revealed a variety of advocacy strategies, including sharing the voices of lived experience, targeting ethnic and cultural groups, myth-busting strategies, and political lobbying. Although a range of strategies were identified, further research is needed to examine advocacy strategies within different countries and political contexts. Furthermore, the impact of specific strategies on stigma reduction, cognitive health promotion, and policy change needs to be scientifically evaluated.

Conclusions
Our study offers valuable insight into strategies to bolster dementia advocacy and awareness campaigns to support people living with dementia. Findings from our research may provide critical insight for policymakers, organizations, and health professionals working to reduce dementia-related stigma and increase the uptake of risk-reduction activities to support the promotion of cognitive health.
Inteligencia emocional y riesgo de abandono escolar en Educación Media Superior en el estado de Durango
Authors: Montes Ramos Frine Virginia , Hernández Jácquez Luis Fernando 
Published: November 2024

La presente investigación se centra en los estudiantes de nuevo ingreso en los planteles adscritos a la Dirección General de Educación Tecnológica Agropecuaria y Ciencias del Mar en el Estado de Durango, México, que son instituciones en las que se identifican tasas de abandono escolar por encima del promedio estatal (20.23%) en los recientes ciclos escolares. Partiendo de ello, los objetivos principales fueron determinar los niveles de inteligencia emocional y de riesgo de abandono escolar, así como la relación entre ambas variables. Los referentes teóricos se fundamentaron en las aportaciones de Mayer y Salovey para la inteligencia emocional y en el modelo de Hernández y Montes, para el riesgo de abandono escolar. Bajo un enfoque de investigación cuantitativo de alcance correlacional con una muestra de 1,529 sujetos, los principales resultados dejaron ver que los estudiantes tienen un bajo nivel de inteligencia emocional para afrontar su vida académica y un nivel moderado de riesgo de abandono escolar, así como un relación negativa entre las variables. Estos resultados podrían ser utilizados para la generación de estrategias que fortalezcan ambas variables y contribuyan a una dismunición en el abandono escolar.
Be Picky: Using communication design to create a brand identity, which is designed to educate young female adults on gut health.
Authors: Craig Holly , Mortensen Steagall Marcos 
Published: November 2024

Using communication design to create a brand identity, which is designed to educate young female adults on gut health and encourage healthier eating. Be Picky is a healthy snack option that advocates for good gut health, by educating and encouraging consumers to make healthier food choices, all while healing their gut. In recent years, studies have shown there to be an evident decline in human gut health, due to the decrease in probiotic-rich foods present in our diets. This leads to poor life quality and a series of other health implications. However, this can be prevented with an increased intake of good bacterias and probiotics, commonly found in fermented foods such as pickles. Using digital illustration, linocut and branding exploration through communication design to create a pickle brand made to benefit your gut health, tailored to appeal to the younger female audience. This project heavily relates to my own experiences regarding gut health, and how a solution like this would greatly improve the quality of life for so many, by motivating others to improve and maintain a healthy gut.
The Shabbat Table
Authors: Mishan Ella , Mortensen Steagall Marcos 
Published: November 2024

This practice-led research and design project examines Jewish diasporic histories retold through food and cuisine. It employs illustration, motif, mapping and colour symbolism to create an environment akin to a Jewish home on Shabbat evening simultaneously commenting on serious topics to develop these ideas within the confinements of publication format. This project aims to develop a deeper level of awareness and understanding of the Jewish people amongst non-Jewish audiences, and other Jewish groups among Jewish audiences, bringing together these important conversations through food.
From Third Place: Illustrations and Observations of Connection in the Inner City
Authors: Naylor Grace Elizabeth , Mortensen Steagall Marcos 
Published: November 2024

From Third Place is a practice-led project that explores the concept of third place in relation to society of the inner city, specifically Auckland CBD, using the traditional cultural anthropological methods of fieldwork and observational drawing to explore third places in Auckland. This project addresses the concept of third place and its role within society and the individual, reflecting on how we connect within our environment. This project is heavily influenced by my previous degree in cultural anthropology and art history. The inquiry is explored through the publication in three chapters of observational illustrations which focuses on the main third places used in everyday life by residents of Auckland CBD; cafes, parks, and pubs. The resulting publication is a series of snapshots of life in the city. The aims of this project is to explore connection of individuals in the city and celebrate the third places that facilitate them.
A Deep Dive: Enhancing Swimmer’s Performance Through Journaling, Value-Based Performance, and Growth Mindset.
Authors: Elliott Blake , Mortensen Steagall Marcos 
Published: November 2024

In ‘A Deep Dive’ I evaluate how journaling, editorial design, and tokens can be used to enhance swimmers’ performance. Becoming a high-performance swimmer requires a strong mindset to overcome challenging situations and perform at the highest level. As an aspiring high-performance swimmer, I have used personal experiences to develop a strategy to overcome these inherent challenges within the sport. Using an autoethnographic and reflective inquiry I incorporate methodologies’ such as drawing, prototyping, critical feedback, digital creation, and photography to bring this project to fruition. Drawing insights from contextual areas such as growth mindset, journaling, value-based performance, and the work of practitioner’s, Maritn Naumann, and Chris Harkin I have created three distinct artifacts: a mindset journal, a book, and five value tokens.
St: Exploring Auckland's St James Theatre as liminal space and picturesque ruin using photography, letterforms, and book design.
Authors: Fee Hillary Billie , Mortensen Steagall Marcos 
Published: November 2024

This practice-led artistic inquiry explores the relationship between letterforms and place. It asks the question: How can letterforms and book design conventions express the phenomenological experience of the eerie urban ruin? The conceptual framework for this research is of the ruin as liminal space sparking imagination and fascination. It embraces the Romanticism historically associated with ruins. St is framed as creative response to the experience of the ruin, centred around letterforms which emphasise the eerie through the interplay of negative and positive space. The resulting decorative alphabet references historic initial letters and illuminated manuscripts. This decorative alphabet is supported by a publication which investigates the history of the St James Theatre and its current derelict state using documentary photography and archival materials. The resulting work integrates text, image and story-telling, elevating letters to the Sublime, alongside architecture and humanity’s other artistic creations which the St James Theatre represents.
APT.5B – 2023 Time Capsule
Authors: Verkade Thammarat Bom , Mortensen Steagall Marcos 
Published: November 2024

This practice-led, artistic project explores the conceptual idea of a book as an object. It is an exploration of materiality and a documentation of artefacts found in APT. 5B. The exegesis talks to the significance of time capsules and the longevity of materials, which cements an everlasting legacy. This capstone involves curating a time capsule which documents a time and place in my life through publication design. It delves into the process of prototyping, an exploration of materials, presented in a publication through an exhibit space. This project aims to stand the test of time, transporting the artefacts, centuries into the future to be discovered. It will act as a testament to the longevity of brutalist materials and the significance of documentation and cataloguing.
The epic and poetics of the Travesía as a space of resistance in design Education.
Authors: González Herbert , Mortensen Steagall Marcos 
Published: November 2024

This paper explores the concept of "Travesías" as a profound pedagogical practice within the School of Architecture and Design at the Pontificia Universidad Católica de Valparaíso, which operates as a crucial form of resistance in design education amidst contemporary cultural and structural shifts. As a professor deeply involved in these journeys, I argue for the retention and adaptation of three foundational principles that ensure the continued relevance and transformative potential of the Travesías. These principles—Observation, the Work (Obra), and the Epic of the Commons—are essential in navigating the changing dynamics that challenge traditional educational models.

As the primary mode of engaging with the world, observation encourages profoundly personal and reflective interaction with the environment, fostering a unique and profound understanding and expression. The concept of the Work transcends conventional outputs of design and architecture, advocating for a creative process that emphasises gratuitousness and poetic engagement over utilitarian and commercial objectives. Lastly, the Epic of the Commons highlights the importance of collective creation and shared experiences, pivotal in forming a cohesive educational and creative community.

These principles are increasingly vital as the Travesías confront the commodification of education and the pervasive focus on individualism and specific competencies driven by market forces. The paper calls for a dialogue among global design educators to discuss adapting these principles to contemporary needs and explore new methods that respect and rejuvenate the foundational ethos of the Travesías. This dialogue is crucial for developing a "third way" in design education that integrates the poetic with the practical, ensuring our pedagogical approach remains innovative, inclusive, and deeply humanistic. Through this exploration, we invite a rethinking of design education that emphasises collective well-being, creative freedom, and a deeper engagement with our time's cultural and ecological contexts.