bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical Management of Migraine Headaches
Authors: Nagori Shakil Ahmed , Jose Anson , Roychoudhury Ajoy 
Published: December 2018

Background
The aim of the present study was to systematically review and analyze the available evidence on the role of surgery in improving outcomes in patients with migraine headaches.

Methods
An electronic search of PubMed, Scopus, CENTRAL (Cochrane Central Register of Controlled Trials), and Google Scholar databases was performed for English-language articles reporting results of peripheral nerve surgery for migraine headaches.

Results
The search strategy revealed a total of 1528 records, of which 23 studies were included in the review. A total of 1151 headache patients were treated in the included studies. The trigger site of migraine addressed varied across studies. Meta-analysis of data of 616 patients revealed that migraine surgery significantly reduces migraine headache frequency (random: mean, 9.52; 95% confidence interval, 7.14–11.9; P < 0.00001; I
2 = 94%). Similarly, when data of 797 patients were analyzed, there was statistically significant reduction in migraine headache intensity in patients undergoing migraine headache surgery (random: mean, 3.97; 95% confidence interval, 3.31–4.62; P < 0.00001; I
2 = 94%). On pooling of data of all 23 studies, 8.3% to 76.4% of patients reported complete elimination of headache after surgery, whereas 3.9% to 33.3% had no relief.

Conclusions
Peripheral nerve decompression surgery is highly effective in reducing migraine headache frequency and migraine headache intensity. However, not all patients benefit from the surgical procedure, with a small subset showing no improvement. Further clinical and anatomical studies are needed to define the exact mechanism of nerve compression in migraine patients and as to why a subset of patients does not respond to surgical treatment.
Gut Barrier Dysfunction Induced by Aggressive Fluid Resuscitation in Severe Acute Pancreatitis is Alleviated by Necroptosis Inhibition in Rats
Authors: Cui Qing-Rui , Ling Yi-Hong , Wen Shi-Hong , Liu Ke-Xuan , Xiang Yu-Ke , Yang Wen-Jing , Shen Jian-Tong , Li Yun-Sheng , Yuan Bao-Long , Huang Wen-Qi 
Published: December 2018

ABSTRACTFluid resuscitation is the first-line antishock treatment in severe acute pancreatitis (SAP). Currently, although mentions of complications related to aggressive fluid resuscitation are very frequent, a lack of proper handling of complications remains. One of the most important complications is intestinal barrier injury, including intestinal ischemia-reperfusion injury following aggressive fluid resuscitation. Once injured, the intestinal barrier may serve as the source of additional diseases, including systemic inflammatory response syndrome and multiple organ dysfunction syndrome, which aggravate SAP. This study focused on the underlying mechanisms of gut barrier dysfunction in rats induced by aggressive fluid resuscitation in SAP. This study further indicated the important role of necroptosis in intestinal barrier injury which could be relieved by using necroptosis-specific inhibitor Nec-1 before aggressive fluid resuscitation, thus reducing intestinal barrier damage. We also found pancreas damage after intestinal ischemia/reperfusion challenge and indicated the effects of high mobility group protein B1 in the vicious cycle between SAP and intestinal barrier damage.
P-Selectin Is Critical for De Novo Pulmonary Arterial Thrombosis Following Blunt Thoracic Trauma
Authors: Schutzman Linda M. , Rigor Robert R. , Khosravi Nasim , Galante Joseph M. , Brown Ian E. 
Published: December 2018

BACKGROUND
Thromboembolic events within the pulmonary arterial vasculature are a troublesome complication of severe blunt thoracic trauma. Mechanisms underlying these events are currently in question as pulmonary thromboembolic events in this particular trauma population tend to be diagnosed more rapidly, more frequently and without an associated systemic thrombosis. This study investigates the role of P-selectin in thrombus formation through the use of in vivo blocking antibodies. We hypothesize that P-selectin plays a pivotal role in de novo pulmonary arterial thrombosis following blunt thoracic trauma.

METHODS
A murine weight-drop model of lateral blunt thoracic trauma was used. Wild-type mice in the experimental group were given blocking antibodies against P-selectin prior to the trauma. All mice were euthanized at 24 hours for evaluation with hematoxylin-eosin staining or immunofluorescent staining for fibrin and P-selectin.

RESULTS
Injured mice that did not receive the P-selectin antibody showed a robust fourfold to fivefold increase in fibrin accumulation in both coup and contrecoup tissues (fluorescence per um of arterial wall) compared to uninjured sham mice. In contrast, mice pretreated with P-selectin blocking antibody showed no significant increase in fibrin accumulation on either side of the lungs after blunt thoracic trauma. No difference in mean fibrin deposition was found between sham controls that received the P-selectin–blocking antibody and those that received an isotype control antibody.

CONCLUSION
P-selectin expression increases at the pulmonary arterial luminal surface following blunt thoracic trauma. In addition, P-selectin–blocking in vivo prevents pulmonary arterial fibrin accumulation after blunt thoracic trauma, confirming that P-selectin is necessary for de novo pulmonary arterial thrombosis after traumatic injury.
The impact of standardized protocol implementation for surgical damage control and temporary abdominal closure after emergent laparotomy
Authors: Loftus Tyler J. , Efron Philip A. , Bala Trina M. , Rosenthal Martin D. , Croft Chasen A. , Walters Michael S. , Smith R. Stephen , Moore Frederick A. , Mohr Alicia M. , Brakenridge Scott C. 
Published: December 2018

BACKGROUND
To standardize care and promote early fascial closure among patients undergoing emergent laparotomy and temporary abdominal closure (TAC), we developed a protocol addressing patient selection, operative technique, resuscitation strategies, and critical care provisions. We hypothesized that primary fascial closure rates would increase following protocol implementation with no difference in complication rates.

STUDY DESIGN
We performed a retrospective cohort analysis of 138 adult trauma and emergency general surgery patients who underwent emergent laparotomy and TAC, comparing protocol patients (n = 60) to recent historic controls (n = 78) who would have met protocol inclusion criteria. The protocol includes low-volume 3% hypertonic saline resuscitation, judicious wound vacuum fluid replacement, and early relaparotomy with sequential fascial closure. Demographics, baseline characteristics, illness severity, resuscitation course, operative management, and outcomes were compared. The primary outcome was fascial closure.

RESULTS
Baseline characteristics, including age, American Society of Anesthesiologists class, and postoperative lactate levels, were similar between groups. Within 48 hours of initial laparotomy and TAC, protocol patients received significantly lower total intravenous fluid resuscitation volumes (9.7 vs. 11.4 L, p = 0.044) and exhibited higher serum osmolarity (303 vs. 293 mOsm/kg, p = 0.001). The interval between abdominal operations was significantly shorter following protocol implementation (28.2 vs. 32.2 hours, p = 0.027). The incidence of primary fascial closure was significantly higher in the protocol group (93% vs. 81%, p = 0.045, number needed to treat = 8.3). Complication rates were similar between groups.

CONCLUSIONS
Protocol implementation was associated with lower crystalloid resuscitation volumes, a transient hyperosmolar state, shorter intervals between operations, and higher fascial closure rates with no difference in complications.

LEVEL OF EVIDENCE
Therapeutic study, level IV.
Peripheral vestibular disorders: an update
Authors: Strupp Michael , Mandalà Marco , López-Escámez Jose A. 
Published: December 2018

Purpose of review
To provide an update on the most frequent peripheral vestibular disorders.

Recent findings
The on-going classification of vestibular disorders by the Bárány Society represents major progress. The diagnosis of bilateral vestibulopathy (BVP) requires quantitative testing of vestibular function. ‘Acute unilateral peripheral vestibulopathy’ (AUPVP) is now preferred over ‘vestibular neuritis.’ Menière's disease is a set of disorders with a significant genetic contribution. The apogeotropic variant of horizontal canal benign paroxysmal positional vertigo (hcBPPV) and anterior canal BPPV (acBPPV) can be distinguished from a central vestibular lesion. Vestibular paroxysmia is now an internationally accepted clinical entity. The diagnosis of SCDS is based on conclusive findings.

Summary
Diagnosis of BVP requires significantly reduced vestibular function. The clinical picture of AUPVP depends on how much the vestibular end organs or their innervation are affected. Menière's disease phenotype is a constellation of symptoms. Although diagnostic and therapeutic criteria for pc and hcBPPV are well defined, a number of less frequent and controversial are increasingly diagnosed and can be treated. Diagnosis of vestibular paroxysmia requires that a patient responds to treatment with a sodium channel blocker. The diagnosis of SCDS requires conclusive findings with various methods. There is still a great need for state-of-the-art randomized controlled treatment trials in most peripheral vestibular disorders.
Acute Phase Treatment Outcomes of Electroconvulsive Therapy in Adolescents and Young Adults
Authors: Benson Nicole M. , Seiner Stephen J. , Bolton Paula , Fitzmaurice Garrett , Meisner Robert C. , Pierce Casey , Busch Alisa B. 
Published: December 2018

Objective
Electroconvulsive therapy (ECT) is a highly efficacious, well-tolerated treatment in adults. Little is known, however, about its effectiveness in adolescents and young adults. Our objectives were to assess clinical outcomes after acute phase ECT in adolescents and young adults and determine whether screening positive or negative for a substance use disorder (SUD) is associated with differences in treatment outcomes.

Methods
Study sample consisted of all patients 16 to 25 years old who received ECT from May 2011 to August 2016 and who completed self-reported SUD screens and the Behavior and Symptom Identification Scale-24 (BASIS-24) initially and completed the BASIS-24 again after the fifth ECT treatment. For 5 BASIS-24 domains, longitudinal changes in mean domain scores were assessed; mean changes by SUD screening status were also examined using linear mixed models.

Results
One hundred ninety adolescents and young adults, with mean age 21.0 ± 2.6 years, met inclusion criteria. Electroconvulsive therapy was associated with significant clinical improvement (score decreases) in all 5 BASIS-24 domains during the acute phase treatment (P < 0.001). Sixty-four percent (122/190) screened positive for SUD. Compared with adolescents and young adults screening negative for SUD, those screening positive for co-occurring SUD had greater improvement in depression/functioning (−0.37 ± 0.14, P = 0.009), interpersonal relationships (−0.27 ± 0.13, P = 0.045), and emotional lability (−0.27 ± 0.14, P = 0.044) domains after the fifth ECT treatment.

Conclusions
Electroconvulsive therapy in adolescents and young adults was associated with significantly improved clinical outcomes during acute phase treatment. Adolescents and young adults screening positive for SUD had better acute phase ECT outcomes in self-reported depression/functioning, interpersonal relationships, and emotional lability than those screening negative. More research is needed to clarify adolescents and young adult patient characteristics that may be associated with differential ECT outcomes.
Decoding the Epitranscriptional Landscape from Native RNA Sequences
Authors: Wongsurawat Thidathip , Jenjaroenpun Piroon , Wassenaar Trudy M. , Wadley Taylor D , Wanchai Visanu , Akel Nisreen S. , Franco Aime T. , Jennings Michael L. , Ussery David W. , Nookaew Intawat 
Published: December 2018

AbstractSequencing of native RNA and corresponding cDNA was performed using Oxford Nanopore Technology. The % Error of Specific Bases (%ESB) was higher for native RNA than for cDNA, which enabled detection of ribonucleotide modification sites. Based on %ESB differences of the two templates, a bioinformatic tool ELIGOS was developed and applied to rRNAs of E. coli, yeast and human cells. ELIGOS captured 91%, 95%, ∼75%, respectively, of the known variety of RNA methylation sites in these rRNAs. Yeast transcriptomes from different growth conditions were also compared, which identified an association between metabolic adaptation and inferred RNA modifications. ELIGOS was further applied to human transcriptome datasets, which identified the well-known DRACH motif containing N6-methyadenine being located close to 3’-untranslated regions of mRNA. Moreover, the RNA G-quadruplex motif was uncovered by ELIGOS. In summary, we have developed an experimental method coupled with bioinformatic software to uncover native RNA modifications and secondary-structures within transcripts.
Mechanistic insights on metabolic dysfunction in PTSD: Role of glucocorticoid receptor sensitivity and energy deficit
Authors: Somvanshi Pramod R. , Mellon Synthia H. , Flory Janine D. , Abu-Amara Duna ,   The PTSD Systems Biology Consortium, Wolkowitz Owen M. , Yehuda Rachel , Jett Marti , Marmar Charles , Doyle Francis J. , Hood Leroy , Wang Kai , Lee Inyoul , Hammamieh Rasha , Gautam Aarti , Daigle Bernie J. , Yang Ruoting 
Published: December 2018

AbstractPTSD is associated with metabolic comorbidities; however it is not clear how the neuroendocrine disturbances affect metabolism. To analyze this we employed a systems biological approach using an integrated mathematical model of metabolism, HPA axis and inflammation. We combined the metabolomics, neuroendocrine, clinical lab and cytokine data from combat-exposed veterans with and without PTSD, to characterize the differences in regulatory effects. We used the pattern of fold change in metabolites representing pathway level differences as reference for metabolic control analysis (MCA) using the model. MCA revealed parameters constituting the HPA axis, inflammation and GPCR pathway that yielded metabolic dysfunction consistent with PTSD. To support this, we performed causal analysis between regulatory components and the significantly different metabolites in our sample. Causal inference revealed that the changes in glucocorticoid receptor sensitivity were mechanistically associated with metabolic dysfunction and the effects were jointly mediated by insulin resistance, inflammation, oxidative stress and energy deficit.
Efficient and specific Ly6G+cell depletion: A change in the current practices toward more relevant functional analyses of neutrophils
Authors: Faget Julien , Boivin Gael , Ancey Pierre-Benoit , Gkasti Aspasia , Mussard Julie , Engblom Camilla , Pfirschke Christina , Vazquez Jessica , Bendriss-Vermare Nathalie , Caux Christophe , Vozenin Marie-Catherine , Pittet Mikael J. , Gunzer Matthias , Meylan Etienne 
Published: December 2018

SummaryNeutrophils orchestrate the innate immune response against microorganisms and are increasingly recognized to modulate cancer development in primary tumors and metastases. To address their functionin vivo, different approaches are used, the most common ones relying on antibody-mediated neutrophil depletion. By comparing the effects of two widely used antibodies, we demonstrate a strong efficacy but a lack of specificity for anti-Gr1. In contrast, anti-Ly6G lacks neutrophil-depletion capacity in C57BL/6 mice, which can be explained by an insufficient celerity of neutrophil clearance that is counterbalanced by exacerbated mobilization of immature cells. When combined with a secondary antibody, anti-Ly6G treatment results in specific and efficient neutrophil depletion. Using a mouse model of lung adenocarcinoma, we demonstrate the efficacy of this new approach to diminish primary tumor growth and propose the existence of a local intercellular communication between neutrophils and alveolar macrophages that fosters regulatory T cell proliferation in lung cancer.
Multi-omics characterization of interaction-mediated control of human protein abundance levels
Authors: Sousa Abel , Gonçalves Emanuel , Mirauta Bogdan , Ochoa David , Stegle Oliver , Beltrao Pedro 
Published: December 2018

AbstractProteogenomic studies of cancer samples have shown that copy number variation can be attenuated at the protein level, for a large fraction of the proteome, likely due to the degradation of unassembled protein complex subunits. Such interaction mediated control of protein abundance remains poorly characterized. To study this we compiled genomic, (phospho)proteomic and structural data for hundreds of cancer samples and find that up to 42% of 8,124 analyzed proteins show signs of post-transcriptional control. We find evidence of interaction dependent control of protein abundance, correlated with interface size, for 516 protein pairs, with some interactions further controlled by phosphorylation. Finally, these findings in cancer were reflected in variation in protein levels in normal tissues. Importantly, expression differences due to natural genetic variation were increasingly buffered from phenotype differences for highly attenuated proteins. Altogether, this study further highlights the importance of post-transcriptional control of protein abundance in cancer and healthy cells.
Blended workplace learning: the value of human interaction
Authors: Hewett Suniti , Becker Karen , Bish Adelle 
Published: December 2018

Purpose
The purpose of this paper is to study the use of blended learning in the workplace and questions whether interpersonal interaction facilitates learner engagement (specifically behavioral, cognitive and/or emotional engagement), and if so, the means by which this occurs.

Design/methodology/approach
A qualitative approach was taken to this exploratory study, a single-case study design was utilized, and data collection methods involved interviews with facilitators and past participants of a blended workplace learning (BWL) program.

Findings
Human interaction in the BWL program included learner–facilitator, learner–learner and learner–colleague interaction. Where human interaction was present, it was reported to be linked with more active behavioral engagement, higher cognitive engagement and stronger and more positive emotional engagement than where human interaction was absent.

Research limitations/implications
The single-case study design does not allow for generalizability of findings. Reliance on self-reported data through interviews without cross-validation from other forms of measurement is a further limitation of the study.

Practical implications
Effective blended learning programs for workplaces are those that provide opportunities for learners to engage through human interaction with facilitators, other learners and colleagues. The findings advance current knowledge of BWL, and have implications for human resource development professionals, and designers and facilitators of blended learning programs for workplaces.

Originality/value
The study contributes to existing literature on blended learning in the workplace and emphasizes the importance of ensuring that human interaction is still an element of blended learning to maximize the benefits to learners and organizations.
Enhancing graduates’ employability skills through authentic learning approaches
Authors: Ornellas Adriana , Falkner Kajsa , Edman Stålbrandt Eva 
Published: December 2018

Purpose
The purpose of this paper is to introduce a theoretical framework based on authentic learning approaches that can be taken into consideration in higher education (HE) contexts to design activities that enable students to develop employability skills.

Design/methodology/approach
Three methods were used to develop the framework: desk research on current demand and supply of new graduate’s employability skills; interviews in four European HE institutions to identify authentic learning scenarios; and asynchronous online focus group to validate the framework.

Findings
The paper takes a competence-centred approach to the concept of employability skills and sets out a taxonomy of skills required to enhance new graduates’ employability. It also gives criteria and examples of authentic learning scenarios in HE settings that promote the acquisition of these skills.

Research limitations/implications
The framework developed remains theoretical. In a second phase, the framework will be applied to implement authentic activities in different programmes and subjects of five HE institutions, and the results will be reported in future publications.

Practical implications
The framework gives directions to create real and practical ways to enhance new graduates’ employability skills by improving the connection between HE curricula and the demands of the real world.

Originality/value
The added value of the paper lies in adopting a learner-centred, genuine and effective learning approach, such as authentic learning as a catalyst for bringing work experience to formal learning in HE institutions, in order to better develop graduates’ employability skills.
Adaptive reuse of historical buildings
Authors: Md Ali Zuraini , Zawawi Rodiah , Myeda Nik Elyna , Mohamad Nabila 
Published: December 2018

PurposeThe purpose of this paper is to focus on the impacts that the adaptive reuse of historical building has on museum service quality by analysing the visitors’ expectations and perceptions through the HISTOQUAL model. It looks deeper into investigating the enhancement of adaptive reuse approach to historical buildings not only to the surrounding environment, but also to the building’s cultural significance.Design/methodology/approachA field survey implementing quantitative approach was conducted by using questionnaires to collect the visitors’ expectations and perceptions on their visits to the selected case study sites. The selected two case study sites are both newly adaptive reuse museums located in the heart of Kuala Lumpur. Through these case studies, the visitors’ expectations and perceptions were analysed and the differences were identified.FindingsPositive feedback on the level of service quality provided at both museums indirectly shows the success of adaptive reuse initiative on the historical buildings towards adapting their new functions as a museum. It was also noted that foreign language leaflets and facilities for less able visitors were among the two service criteria that do not exceed the expectations of users. In general, these findings are crucial in identifying the gap within the services provided and appropriate measures that can be undertaken for further improvement.Research limitations/implicationsFurther study can be employed to a larger population of study to cater for a variety of perspectives from both users and managers of the buildings.Practical implicationsThis paper highlights the implications of users’ feedback towards building usability and functions. It provided imperative findings from the users’ point of view pertaining to the services provided.Social implicationsThe paper illustrates the significance of social perceptions on the implications of service delivery. It also reports empirical evidence in highlighting the importance of users’ attributes towards excellent service delivery.Originality/valueUp to present, there exists a small number of studies that look into reviewing the new functions of adaptive reuse buildings. This study now contributes to create a larger number of studies in this scope, especially within the context of Malaysia.