bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unrecognized pre‐transplant disseminated Coxiella burnetti infection diagnosed in a post‐transplant heart‐kidney recipient
Authors: Jandhyala Deeksha , Farid Saira , Mahmood Maryam , Deziel Paul , Abu Saleh Omar , Raoult Didier , Beam Elena 
Published: July 2018

AbstractTo the best of our knowledge, we report the first case of pre‐transplant unrecognized disseminated Coxiella burnetii infection, unmasked in the post‐transplant period leading to both heart and kidney allograft dysfunction. A 59 year old man with a history of simultaneous heart‐kidney transplantation due to end stage heart failure from severe aortic regurgitation (AR) and cryoglobulinemic immune complex mediated concentric necrotizing glomerulonephritis (GN), presents with a history of intermittent fevers and fatigue. Prior to transplantation he was treated for multiple episodes of culture negative endocarditis requiring bio‐prosthetic valve replacement. Evaluation of fever included a transesophageal echocardiogram (TEE) that revealed a large hyperechoic mass on the anterior mitral leaflet with perforation, severe mitral regurgitation and moderate AR. Blood cultures were negative at that time. Owing to development of allograft mitral and aortic valve insufficiency, he underwent allograft bio‐prosthetic mitral valve (MV) replacement and aortic valvuloplasty 2 years following his transplantation. Pathologic examination of the allograft mitral valve demonstrated fibrinopurulent exudate with degenerating bacterial organisms, consistent with vegetation and myxoid degenerative changes. Due to a high suspicion for native heart C. burnetii prosthetic valve endocarditis prior to transplantation, we re‐evaluated the native explanted heart histopathology, as well as the explanted allograft MV. Cardiac allograft and native MV were positive for C. burnetii by real‐time PCR. C. burnetii serology was consistent with persistent infection as well.
Evolutionary history of the genus Sorex (Soricidae, Eulipotyphla) as inferred from multigene data
Authors: Bannikova Anna A. , Chernetskaya Daria , Raspopova Alexandra , Alexandrov Dmitry , Fang Yun , Dokuchaev Nikolai , Sheftel Boris , Lebedev Vladimir 
Published: July 2018

AbstractThe genus Sorex is one of the most diverse and ecologically successful lineages of the family Soricidae. We present the first multilocus nuclear phylogeny focusing on the nominal subgenus Sorex s.str., which is distributed mainly in the northern Palearctic. The nuclear tree (six exons) provides more resolution than the mitochondrial data (cytb) and supports subdivision into eight species groups within Sorex s.str., most of which correspond to those recognized from chromosome data. The European species S. alpinus is consistently placed as the basal lineage in the Palearctic clade, while the next split separates the east‐Tibetan group of striped shrews (S. aff. cylindricauda, S. bedfordiae, S. excelsus). Within the remaining species, the following well‐supported clades are identified at the supra‐group level: “araneus” species group+S. samniticus; the “caecutiens” group+the “minutus” group, the latter also including S. minutissimus, S. gracillimus and S. thibetanus. S. raddei and S. roboratus represent separate lineages with no close relatives. The fossil‐calibrated molecular clock placed the divergence between Sorex s.str. and Otisorex at the Early/Middle Miocene boundary. Basal radiation of the crown Sorex s.str. was estimated to have occurred in the middle of the Late Miocene. A more than threefold increase in the diversification rate is inferred for the Early Pliocene. Taxonomic implications including potential genus ranks for Sorex s.str. and Otisorex are discussed. S. alpinus is placed in the monotypic subgenus Homalurus. The full species status of S. buchariensis and S. thibetanus and close relationships between S. cf. cansulus and S. caecutiens are confirmed.
Sex‐based differences in apnoea of prematurity: A retrospective cohort study
Authors: Bairam Aida , Laflamme Nathalie , Drolet Christine , Piedboeuf Bruno , Shah Prakesh S. , Kinkead Richard ,   on behalf of the Canadian Neonatal Network Investigators
Published: July 2018

New Findings
What is the central question of the study?
Is there a sex‐based difference in the incidence of apnoea of prematurity and the success or failure of caffeine therapy in preterm infants?

What is the main finding and its importance?
Our data show that females received fewer days of caffeine treatment than males. This was most noticeable in infants born between 260/7 and 276/7 weeks of gestational age. These results highlight the importance of considering sex in clinical and basic research investigating the pathophysiology of apnoea of prematurity.

AbstractThis retrospective cohort study assessed whether sex influences the occurrence of apnoea of prematurity (AOP) in preterm infants. The analysis included a cohort of 24,387 preterm infants born between the gestational ages (GA) of 240/7 and 336/7 weeks that were admitted to tertiary neonatal care units participating in the Canadian Neonatal Network from January 2011 to December 2015. Of those, 13,983 (57%) were diagnosed with AOP. More females were diagnosed with AOP than males, but the difference in the male/female ratio was marginal (P = 0.058). The majority (89%) of infants diagnosed with AOP received caffeine (89% of males; 89% of females). By using the discontinuation of caffeine therapy as a proxy for the resolution of significant AOP, data analysis showed that females born before 336/7 weeks of GA stopped caffeine treatment earlier than males whether the caffeine was discontinued before 34 or 37 weeks of GA. Consequently, females had fewer days of caffeine therapy than males, especially infants born between 260/7 and 276/7 weeks (P < 0.004), 280/7 and 296/7 weeks (P < 0.03), and 320/7 and 336/7 weeks of GA (P < 0.04). Similar trends were observed when the corrected GA at discontinuation of caffeine was used. Given that AOP is indicative of an immature respiratory system, our data suggest that the maturation of the respiratory system might occur more rapidly in females than males. We conclude that sex needs to be considered in future studies on AOP.
MuscleIO
Authors: Duente Tim , Schulte Justin , Pfeiffer Max , Rohs Michael 
Published: July 2018

Receiving and reacting to notifications on mobile devices can be cumbersome. We propose MuscleIO, the use of electrical muscle stimulation (EMS) for notification output and electromyography (EMG) for reacting to notifications. Our approach provides a one-handed, eyes-free, and low-effort way of dealing with notifications. We built a prototype that interleaves muscle input and muscle output signals using the same electrodes. EMS and EMG alternate such that the EMG input signal is measured in the gaps of the EMS output signal, so voluntary muscle contraction is measured during muscle stimulation.
Notifications are represented as EMS signals and are accepted or refused either by a directional or a time-based EMG response. A lab user study with 12 participants shows that the directional EMG response is superior to the time-based response in terms of reaction time, error rate, and user preference. Furthermore, the directional approach is the fastest and the most intuitive for users compared to a button-based smartwatch interface as a baseline.
Energy-Ball
Authors: Fan Xiaoran , Ding Han , Li Sugang , Sanzari Michael , Zhang Yanyong , Trappe Wade , Han Zhu , Howard Richard E. 
Published: July 2018

Wireless power transfer (WPT) promises to deliver energy to devices that are otherwise hard to charge or replace batteries for. This paper presents a new power transfer approach by aligning the phases of a collection of radio frequency (RF) energy chargers at the target receiver device. Our approach can ship energy over tens of meters and to mobile targets. More importantly, our approach leads to a highly asymmetric energy density distribution in the charging area: the energy density at the target receiver is much higher than the energy density at other locations. It is a departure from existing beamforming based WPT systems that have high energy along the energy beam path. Such a technology can enable a large array of batteryless Internet of Things applications and render them much more robust and long-running. Thanks to its asymmetric energy distribution, our approach potentially can be scaled up to ship higher level of energy over longer distances.
In this paper, we design, prototype, and evaluate the proposed energy transfer approach, referred to as Energy-Ball. We implement an Energy-Ball testbed that consists of 17 N210 and 4 B210 Universal Software Radio Peripheral (USRP) nodes, yielding a 20 x 20 m2 energy delivery area. We conduct carefully designed experiments on the testbed. We demo that the energy density of Energy-Ball at the target spot is considerably higher than the energy density elsewhere, with the peak to average power ratio of 8.72. We show that Energy-Ball can transfer energy to any point within the area. When the receiver moves at a speed of 0.5 m/s, Energy-Ball can transfer 80% of optimal power to the mobile receiver. Further, our results also show Energy-Ball can deliver over 0.6mw RF power that enables batteryless sensors at any point across the area.
Addressing The Privacy Paradox through Personalized Privacy Notifications
Authors: Jackson Corey Brian , Wang Yang 
Published: July 2018

Privacy behaviors of individuals are often inconsistent with their stated attitudes, a phenomenon known as the "privacy paradox." These inconsistencies may lead to troublesome or regrettable experiences. To help people address these privacy inconsistencies, we propose a personalized privacy notification approach that juxtaposes users' general privacy attitudes towards specific technologies and the potential privacy riskiness of particular instances of such technology, right when users make decisions about whether and/or how to use the technology under consideration. Highlighting the privacy inconsistencies to users was designed to nudge them in making decisions in a way that aligns with their privacy attitudes.
To illustrate this approach, we chose the domain of mobile apps and designed a privacy discrepancy interface that highlights this discrepancy between users' general privacy attitudes towards mobile apps and the potential privacy riskiness of a particular app, nudging them to make app installation and/or permission granting decisions reflecting their privacy attitudes. To evaluate this interface, we conducted an online experiment simulating the process of installing Android apps. We compared the privacy discrepancy approach with several existing privacy notification approaches. Our results suggest that the behaviors of participants who used the privacy discrepancy interface better reflected their privacy attitudes than the other approaches.
Duet
Authors: Vasisht Deepak , Jain Anubhav , Hsu Chen-Yu , Kabelac Zachary , Katabi Dina 
Published: July 2018

Although past work on RF-based indoor localization has delivered important advances, it typically makes assumptions that hinder its adoption in smart home applications. Most localization systems assume that users carry their phones on them at home, an assumption that has been proven highly inaccurate in past measurements. The few localization systems that do not require the user to carry a device on her, cannot tell the identity of the person; yet identification is essential to most smart home applications. This paper focuses on addressing these issues so that smart homes can benefit from recent advances in indoor localization.
We introduce Duet, a multi-modal system that takes as input measurements from both device-based and device-free localization. Duet introduces a new framework that combines probabilistic inference with first order logic to reason about the users' most likely locations and identities in light of the measurements. We implement Duet and compare it with a baseline that uses state-of-art WiFi-based localization. The results of two weeks of monitoring in two smart environments show that Duet accurately localizes and identifies the users for 94% and 96% of the time in the two places. In contrast, the baseline is accurate 17% and 42% respectively.
Phenotypical heterogeneity in responder and nonresponder male ApoE*3Leiden.CETP mice
Authors: Tarasco Erika , Pellegrini Giovanni , Whiting Lynda , Lutz Thomas A. 
Published: July 2018

The metabolic syndrome (MetS) is a major health issue worldwide and is associated with obesity, insulin resistance, and hypercholesterolemia. Several animal models were used to describe the MetS; however, many of them do not mimic well the MetS pathophysiology in humans. The ApoE*3Leiden.CETP mouse model overcomes part of this limitation, since they have a humanised lipoprotein metabolism and a heterogeneous response to MetS, similar to humans. The reported heterogeneity among them and their common classification refer to responder (R) and nonresponder (NR) mice; R mice show increased body weight, cholesterol, and triglycerides levels, whereas NR mice do not show this expected phenotype when fed a Western type diet. To define better the differences between R and NR mice, we focused on feeding behavior, body weight gain, glucose tolerance, and lipid parameters, and on an extensive pathological examination along with liver histology analysis. Our data confirmed that R mice resemble the pathological features of the human MetS: obesity, dysplipidemia, and glucose intolerance. NR mice do not develop the full dysmetabolic phenotype because of a severe inflammatory hepatic condition, which may heavily affect liver function. We conclude that R and NR mice are metabolically different and that NR mice have indications of severely impaired liver function. Hence, it is critical to identify and separate the respective mice to decrease data heterogeneity. Clinical chemistry and histological analysis should be used to confirm retrospectively the animals’ classification. Moreover, we point out that NR mice may not be an appropriate control for studies involving ApoE*3Leiden.CETP R mice. NEW & NOTEWORTHY When compared with some other animal models, ApoE*3Leiden.CETP mice are better models to describe the metabolic syndrome. However, there is phenotypic heterogeneity between “responder” and “nonresponder” mice, the latter showing some evidence of hepatic pathology. A full phenotypic characterization and eventually postmortem analysis of the liver are warranted.
Circulating PIWI-Interacting RNAs piR-5937 and piR-28876 Are Promising Diagnostic Biomarkers of Colon Cancer
Authors: Vychytilova-Faltejskova Petra , Stitkovcova Karolina , Radova Lenka , Sachlova Milana , Kosarova Zdenka , Slaba Katerina , Kala Zdenek , Svoboda Marek , Kiss Igor , Vyzula Rostislav , Cho William C. , Slaby Ondrej 
Published: July 2018

Abstract
Background: The early detection of colon cancer is one of the main prerequisites for successful treatment and mortality reduction. Circulating PIWI-interacting RNAs (piRNA) were recently identified as novel promising biomarkers. The purpose of the study was to assess the profiles of piRNAs in blood serum of colon cancer patients with the aim to identify those with high diagnostic potential.
Methods: Blood serum samples from 403 colon cancer patients and 276 healthy donors were included in this 3-phase biomarker study. Large-scale piRNA expression profiling was performed using Illumina small RNA sequencing. The diagnostic potential of selected piRNAs was further validated on independent training and validation sets of samples using RT-qPCR.
Results: In total, 31 piRNAs were found to be significantly deregulated in serum of cancer patients compared with healthy donors. Based on the levels of piR-5937 and piR-28876, it was possible to differentiate between cancer patients and healthy donors with high sensitivity and specificity. Moreover, both piRNAs exhibited satisfactory diagnostic performance also in patients with stage I disease and enabled detection of colon cancer with higher sensitivity than currently used biomarkers CEA and CA19-9. Finally, the expression of analyzed piRNAs in blood restored significantly 1 month after the surgical resection.
Conclusions: Based on our findings, piRNAs are abundant in human blood serum. Furthermore, their levels in colon cancer have been observed to be significantly deregulated. However, their involvement in carcinogenesis must be further established.
Impact: piRNAs could serve as promising noninvasive biomarkers for early detection of colon cancer. Cancer Epidemiol Biomarkers Prev; 27(9); 1019–28. ©2018 AACR.
CRISPR-Cas9–Mediated Epitope Tagging Provides Accurate and Versatile Assessment of Myocardin—Brief Report
Authors: Lyu Qing , Dhagia Vidhi , Han Yu , Guo Bing , Wines-Samuelson Mary E. , Christie Christine K. , Yin Qiangzong , Slivano Orazio J. , Herring Paul , Long Xiaochun , Gupte Sachin A. , Miano Joseph M. 
Published: July 2018

Objective—

Unreliable antibodies often hinder the accurate detection of an endogenous protein, and this is particularly true for the cardiac and smooth muscle cofactor, MYOCD (myocardin). Accordingly, the mouse
Myocd
locus was targeted with 2 independent epitope tags for the unambiguous expression, localization, and activity of MYOCD protein.

Approach and Results—

3cCRISPR (3-component clustered regularly interspaced short palindromic repeat) was used to engineer a carboxyl-terminal 3×FLAG or 3×HA epitope tag in mouse embryos. Western blotting with antibodies to each tag revealed a MYOCD protein product of ≈150 kDa, a size considerably larger than that reported in virtually all publications. MYOCD protein was most abundant in some adult smooth muscle-containing tissues with surprisingly low-level expression in the heart. Both alleles of
Myocd
are active in aorta because a 2-fold increase in protein was seen in mice homozygous versus heterozygous for FLAG-tagged
Myocd
. ChIP (chromatin immunoprecipitation)–quantitative polymerase chain reaction studies provide proof-of-principle data demonstrating the utility of this mouse line in conducting genome-wide ChIP-seq studies to ascertain the full complement of MYOCD-dependent target genes in vivo. Although FLAG-tagged MYOCD protein was undetectable in sections of adult mouse tissues, low-passaged vascular smooth muscle cells exhibited expected nuclear localization.

Conclusions—
This report validates new mouse models for analyzing MYOCD protein expression, localization, and binding activity in vivo and highlights the need for rigorous authentication of antibodies in biomedical research.
On the Role of Accent in Ancient Greek Poetry
Authors: Abritta Alejandro 
Published: July 2018

Abstract
In this paper, I set out to study the distribution of some accentual types of two different word shapes in the Homeric hexameter: iambs and iambic ending words and dactyls and dactylic ending words. Following Nagy 2000 and 2010 and David 2006, I start from the idea that accent has a role in Ancient Greek poetry, which has been corroborated in Abritta 2015 by studying the distribution of trochaic ending words. In the sections corresponding to each word shape, after a statistical consideration of the distribution, I examine some literary uses of accentual types, which the poet places in the line apparently in order to produce a certain effect on the audience. The article is conceived as a first approximation to the study of accentual distribution in Ancient Greek poetry.
Patient reported outcomes with remote orthopaedic consultations by telemedicine: A randomised controlled trial
Authors: Buvik Astrid , Bugge Einar , Knutsen Gunnar , Småbrekke Arvid , Wilsgaard Tom 
Published: July 2018

Introduction Decentralised services through outreach clinics or modern technology reduce patient travel time and cost to society. Telemedicine consultation through videoconference is one such modality. Here, we compared patient-reported health outcomes and satisfaction between video-assisted remote and standard face-to-face orthopaedic consultations. Methods This randomised controlled trial included two parallel groups: (1) patients receiving video-assisted remote consultation at a regional medical centre (RMC); and (2) patients receiving standard consultation at the orthopaedic outpatient clinic of the University Hospital of North Norway (UNN). This study included patients referred to or scheduled for a consultation at the orthopaedic outpatient clinic. After each consultation, patient satisfaction was determined using patient-completed questionnaires containing questions on patient-reported health (three-level European quality of life five-dimension index (EQ-5D-3L)/European quality of life visual analogue scale (EQ-VAS)) and questions from a validated OutPatient Experiences Questionnaire (OPEQ). Results This study included 389 patients, of which 199 received remote consultation and 190 received standard consultation (total of 559 consultations). In all, 99% RMC-randomised patients and 99% UNN-randomised patients evaluated the consultation as very satisfactory or satisfactory. Moreover, 86% RMC-randomised patients preferred video-assisted consultation as the next consultation. No difference was observed in patient-reported health after 12 months between the two groups. EQ-5D index scores were 0.77 and 0.75 for RMC- and UNN-randomised patients, respectively ( p = 0.42). Discussion We did not observe any difference in patient-reported satisfaction and health (EQ-5D/EQ-VAS) between video-assisted and standard consultations, suggesting that video-assisted remote consultation can be safely offered to some orthopaedic patients. Moreover, a significantly high proportion of patients selected video-assisted remote consultation as their next consultation, thus strengthening the findings of this study. However, economic aspects should be assessed before widely recommending video-assisted consultation.
Normal saline versus Normosol™-R in sepsis resuscitation: A retrospective cohort study
Authors: Duffy Ryan A , Foroozesh Mathab B , Loflin Robert D , Ie Susanti R , Icard Bradley L , Tegge Allison N , Nogueira Jonathan R , Kuehl Damon R , Smith Dan C , Loschner Anthony L 
Published: July 2018

Objective To determine the effect of Normosol™-R as compared to normal saline on the outcomes of acute kidney injury and the need for renal replacement therapy in the resuscitation phase of sepsis. Design Our study is a retrospective before-and-after cohort study. Setting The study occurred at a 700-bed tertiary academic level 1-trauma center. Patients A total of 1218 patients were enrolled through emergency department admissions. The normal saline (before) cohort was defined as the dates between 1 March and 30 September 2014 and the Normosol™-R (after) cohort was assessed from 1 March to 30 September 2015. Interventions None. Measurements and main results Intravenous fluid volumes received during the first 24 h, 72 h, and total hospital stays were compared. Sodium, chloride, potassium, and bicarbonate levels at 72 h were also compared. The medical coded diagnosis of acute kidney failure, need for renal replacement therapy, hospital LOS, ICU admission, ICU LOS, in-hospital mortality, and need for mechanical ventilation were all compared. There was no significant difference in intravenous fluid volumes between groups. Regression modelling controlling for baseline characteristics and 24-h fluid intake volume found no differences between groups for the primary outcomes of acute kidney injury ( P = 0.99) and renal replacement therapy ( P = 0.88). Patients in the Normosol™-R cohort were found to have a lower rate of hyperchloremia at 72 h post-admission (28% vs. 13%, P < 0.0001). There was a trend toward a decrease in the hospital and ICU LOS in the Normosol™-R cohort; however, the data were not statistically significant. Conclusions This study was unable to detect any difference in outcomes between sepsis patients who received intravenous fluid resuscitation with either a balanced crystalloid (Normosol™-R) or normal saline, except for a decreased rate of hyperchloremia.