bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Charged, Cytotoxic, Cyclometalated Iridium(III) Complexes as Cancer Stem Cell Mitochondriotropics
Authors: Laws Kristine , Eskandari Arvin , Lu Chunxin , Suntharalingam Kogularamanan 
Published: July 2018

AbstractThe cancer stem cell (CSC) toxicity and mechanism of action of a series of iridium(III) complexes bearing polypridyl and charged 1‐methyl‐2‐(2‐pyridyl)pyridinium ligands, 1–4 is reported. The most effective complex (containing 1,10‐phenanthroline), 3, kills CSCs and bulk cancer cells with equal potency (in the micromolar range), indicating that it could potentially remove heterogenous tumour populations with a single dose. Encouragingly, 3 also inhibits mammopshere formation to a similar extent as salinomycin, a well‐established anti‐CSC agent. This complex induces CSC apoptosis by mitochondrial membrane depolarization, inhibition of mitochondrial metabolism, and intracellular reactive oxygen species (ROS) generation. To the best of our knowledge, this is the first study to investigate the anti‐CSC properties of iridium complexes.
Highly enantioselective Michael addition of pyrazolin‐5‐ones to nitroolefins catalyzed by cinchona alkaloid derived 4‐methylbenzoylthioureas
Authors: Yang Mengchen , Zhang Min , Wang Zhenyu , Tang Li , Chen Wenbin , Ban Shurong , Li Qingshan 
Published: July 2018

AbstractCinchona alkaloid‐derived 4‐methyl/nitro benzoylthioureas were synthesized, which smoothly catalyzed the asymmetric Michael addition of pyrazolin‐5‐ones to nitroolefins. The results showed that electronic effects of substituents in the benzene ring of benzoylthioureas have subtle influences on their catalytic abilities and electron donating methyl group is favored than electron withdrawing nitro group. Preliminary Hartree‐Fock calculations revealed that in the catalytic cycle, hydrogen bond energies of the complex formed with 4‐methylbenzoylthioureas are about 0.19 to 1.56 kcal/mol higher than with the corresponding 4‐nitrobenzoylthioureas. 4‐Methylbenzoylthioureas were identified as the most effective catalysts that promoted asymmetric Michael addition of pyrazolin‐5‐ones to nitroolefins to give the S‐ or R‐products with high enantioselectivities.
Expression of human papillomavirus oncoproteins E6 and E7 inhibits invadopodia activity but promotes cell migration in HPV‐positive head and neck squamous cell carcinoma cells
Authors: Kahue Charissa N. , Jerrell Rachel J. , Parekh Aron 
Published: July 2018

AbstractBackgroundThe rapid increase in the incidence of head and neck squamous cell carcinoma (HNSCC) is caused by high‐risk human papillomavirus (HPV) infections. The HPV oncogenes E6 and E7 promote carcinogenesis by disrupting signaling pathways that control survival and proliferation. Although these cancers are often diagnosed with metastases, the mechanisms that regulate their dissemination are unknown.AimsThe aim of this study was to determine whether the HPV‐16 E6 and E7 oncogenes affected the invasive and migratory properties of HNSCC cells which promote their spread and metastasis.Methods and resultsInvasiveness was determined using invadopodia assays which allow for quantitation of extracellular matrix (ECM) degradation by invadopodia which are proteolytic membrane protrusions that facilitate invasion. Using cell lines and genetic manipulations, we found that HPV inhibited invadopodia activity in aggressive cell lines which was mediated by the E6 and E7 oncogenes. Given these findings, we also tested whether HPV caused differences in the migratory ability of HNSCC cells using Transwell assays. In contrast to our invadopodia results, we found no correlation between HPV status and cell migration; however, blocking the expression of the E6 and E7 oncoproteins in a HPV‐positive (HPV+) HNSCC cell line resulted in decreased migration.ConclusionsOur data suggest that the E6 and E7 oncoproteins are negative regulators of invadopodia activity but may promote migration in HPV+ HNSCC cells. Despite the need for ECM proteolysis to penetrate most tissues, the unique structure of the head and neck tissues in which these cancers arise may facilitate the spread of migratory cancer cells without significant proteolytic ability.
Universal models of colour emotion and colour harmony
Authors: Ou Li‐Chen , Yuan Yinqiu , Sato Tetsuya , Lee Wen‐Yuan , Szabó Ferenc , Sueeprasan Suchitra , Huertas Rafael 
Published: July 2018

AbstractA new set of quantitative models of colour emotion and colour harmony were developed in this study using psychophysical data collected from 12 regions in the world, including Argentina, China, France, Germany, Hungary, Iran, Japan, Spain, Sweden, Taiwan, Thailand, and the UK. These data have previously been published in journals or conferences (for details see Tables and ). For colour emotion, three new models were derived, showing satisfactory predictive performance in terms of an average correlation coefficient of 0.78 for “warm/cool”, 0.80 for “heavy/light” and 0.81 for “active/passive”. The new colour harmony model also had satisfactory predictive performance, with an average correlation coefficient of 0.72. Principal component analysis shows that the common colour harmony principles, including hue similarity, chroma similarity, lightness difference and high lightness principles, were partly agreed by observers of the same region. The findings suggest that it is feasible to develop universal models of colour emotion and colour harmony, and that the former was found to be relatively more culture‐independent than the latter.
Neuro‐fuzzy model for HELLP syndrome prediction in mobile cloud computing environments
Authors: Moreira Mário W. L. , Rodrigues Joel J. P. C. , Al‐Muhtadi Jalal , Korotaev Valery V. , de Albuquerque Victor Hugo C. 
Published: July 2018

SummaryThe exchange of information among health professionals is a common practice among clinics, laboratories, and hospitals. Cloud‐based clinical data exchange platforms enable valuable information to be available in real time and in a secure and private manner. The increasing availability of data in health information systems allows specialists to extract knowledge using pattern recognition techniques for the identification and prediction of risk situations that could lead to severe complications for a patient. Hence, this paper proposes the use of a neuro‐fuzzy machine learning technique for predicting the most complex hypertensive disorder in pregnancy called HELLP syndrome. This classifier serves as an inference mechanism for cloud‐based mobile applications, for effective monitoring through the analysis of symptoms presented by pregnant women. Results show that the proposed model achieves excellent results regarding several indicators, such as precision (0.685), recall (0.756), the F‐measure (0.705), and the area under the receiver operating characteristic curve (0.829). This technique can accurately predict situations that could lead to the death of both a mother and fetus, at any location and time.
Opto‐electric target tracking algorithm based on local feature selection and particle filter optimization
Authors: Peng Liangqing , Wu Yanpeng , Huang Lei 
Published: July 2018

SummaryAiming at exploring the opto‐electric target tracking, which is an important technology in the field of computer vision, the binocular stereo vision camera opto‐electric target tracking is studied and and a multi feature fusion characterization modeling method locally weighted is proposed. The target area is divided into multiple sub‐image areas by the modeling method, the feature histogram after the background weighting is extracted, and the sub‐image region is taken as a basic unit for adjusting the feature weight. The sub‐image area selected is regarded as the significant area, and the significant area is further extracted and fused in particle filter tracking algorithm. Then, the obtained significant are is conducted with color distribution processing. In the state prediction stage, the Mean Shift algorithm is applied to optimize each particle so that it converges to the optimal position. The experiment results showed that the multi feature fusion representation modeling method has better tracking accuracy and stability compared with the traditional fusion method and after the color distribution treatment; it has strong anti‐jamming for background effect. It is concluded that using Mean Shift algorithm for particle optimization can further strengthen the accurate tracking of the targets.
SAHARA
Authors: Mayhew David 
Published: July 2018

SummaryFaster, lower power, and/or less expensive computation will be a software problem forever. Hardware can only make the challenge simpler or harder and heterogeneous approaches exacerbate it. For emerging alternative computational technologies like quantum, optical, resistive (and other forms of analog computation), and/or biological computing (among others), to be successful, they must be integrated into the existing computational infrastructure (both hardware and software) if they are to realize their full potential. The increasingly main‐stream options that reconfigurable logic represents (both fine and coarse grained) will also be most useful within an infrastructure that is sympathetic to legacy memory and storage models. SAHARA is a reduction of computation into data wavefronts that, independent of the underlying technology, employs memory as the fundamental unit of computation within a simple data‐flow model, essentially turning processing into a side‐effect of the relevant data being made available to the logic that manipulates that data. No single aspect of SAHARA is “new”. Its foundations are more than 50 years old and started with Minsky's 1961 paper on Turing equivalence. SAHARA is an eminently useful abstraction of computation that has the potential of seamlessly integrating many disparate forms of computation behind a simple, common, architectural interface.
Environmental indicators of sustainable computing applications for Smart City
Authors: Zhang Yan , Pu Haitao 
Published: July 2018

SummaryIn the past decades, China has experienced rapid industrialization and urbanization, which has caused severe environmental pollution issues and hampered the sustainable development. To cope with these problems, a plethora of environmental protection policies has been presented by the Chinese government. Thus, determining the most reasonable environmental performance indicators is becoming an essential requirement for evaluating the effectiveness and efficiency of governmental management policy to the sustainable development of the ecological system. In this paper, we propose a group of environmental indicators including air quality index, water quality index, and soil quality index that are constructed specifically for evaluating the severity of environment pollution, and the implementation of corresponding governance policy as the pollution issue is one of the most severe risks to population health among all of the current existing problems in China. The proposed indicators are composed of the indices, which were selected by leveraging on the data acquired from China National Bureau of Statistics. Based on the proposed environmental quality indicators, we provide recommendations of governmental policy for improving the environmental performance in mining regions.
Cost optimization heuristics for deadline constrained workflow scheduling on clouds and their comparative evaluation
Authors: Emmanuel Bugingo , Qin Yingsheng , Wang Juntao , Zhang Defu , Zheng Wei 
Published: July 2018

SummaryNowadays, cloud service providers usually offer users virtual machines with various combinations of configurations and prices. As this new service scheme emerges, the problem of choosing the cost‐minimized combination under a deadline constraint is becoming more complex for users. The complexity of determining the cost‐minimized combination may be resulted from different causes: the characteristics of user applications and providers' setting on the configurations and pricing of virtual machine. In this paper, we proposed an algorithm with two variants to help the users to schedule their workflow applications on clouds so that the cost can be minimized and the deadline constraints can be satisfied. The proposed algorithm is evaluated by extensive simulation experiments with two realistic workflows.
Parallel Semi‐supervised enhanced fuzzy Co‐Clustering (PSEFC) and Rapid Association Rule Mining (RARM) based frequent route mining algorithm for travel sequence recommendation on big social media
Authors: Suresh Kumar N. , Thangamani M. 
Published: July 2018

SummaryIn this proposed method, with the aim of resolving the frequent route mining issue, by means of utilizing the Rapid Association Rule Mining (RARM) for frequent route mining, recurrently utilized routes as well as smaller distance routes are mined. As a result, support speedy decision of the route identify more willingly than the standard route optimization. Primarily, Multi‐Ontology based Points of Interest (MO‐POIs) model is presented that takes the POIs of user design in combination with the semantic info of the individual users. Furthermore, it as well takes another two steps that are along these lines: (1) routes ranking as per the similarity amid user package as well as routes packages are carried out by means of utilizing Parallel Semi‐supervised enhanced fuzzy Co‐Clustering (PSEFC) as well as (2) route optimizing by Parallel Ant Colony Optimization (PACO) technique in keeping with identical social users' records. The graph model is denoted as the amount of ants in the population of the identical user records. Assess the RARM‐PSEFC recommendation system on a set of Flickr images uploaded by users as well as travel POIs in numerous cities and show its efficiency.
Genesis of MgCl2‐based Ziegler‐Natta Catalysts as Probed with Operando Spectroscopy
Authors: Piovano Alessandro , Pletcher Paul , Velthoen Marjolein E. Z. , Zanoni Silvia , Chung Sang‐Ho , Bossers Koen , Jongkind Maarten K. , Fiore Gianluca , Groppo Elena , Weckhuysen Bert M. 
Published: July 2018

AbstractZiegler‐Natta catalysts for olefin polymerization are intrinsically complex multi‐component systems. The genesis of the active sites involves several simultaneous and sequential steps, making the individual steps and interconnections difficult to be unraveled in an unambiguous manner. In this work, we combine X‐ray diffraction and spectroscopy to probe each step of the birth and life of a MgCl2‐based Ziegler‐Natta catalyst, namely the formation of high surface area MgCl2 by dealcoholation of an alcoholate precursor, the TiCl4 grafting, and the subsequent activation by triethylaluminum as co‐catalyst. The so‐prepared catalyst was tested towards ethylene polymerization, leading to the production of mainly crystalline high‐density polyethylene. The use of operando characterization techniques allowed probing the transient details that are difficult to be dissected in the aftermath, but can radically affect the overall catalytic process.
Design and Synthesis of Energetic Materials towards Versatile Applications by N‐trinitromethyl and N‐nitromethyl Functionalization of Nitroimidazoles
Authors: Yin Xin , Li Jie , Zhang Guojie , Zhang Zhenqi , Ma Qing , Wang Jun , Wang Shumin 
Published: July 2018

AbstractModifying the properties of energetic materials is important not only for gaining insight into the relationship between structures and properties but also for multiple applications. A new family of energetic compounds, polynitroimidazoles featuring trinitromethyl, nitromethyl and methyl acetate moieties at the nitrogen position of heterocyclic rings were synthesized. The high‐energy oxidizers 2‐nitro and 4‐nitro‐1‐(trinitromethyl)‐1H‐imidazoles were obtained by nitration of 1‐acetonylpolynitroimidazoles in fuming HNO3 and concentrated H2SO4. 4,5‐Dinitro‐1‐(nitromethyl)‐1H‐imidazole and 4,5‐dinitro‐1‐(acetate methyl)‐1H‐imidazole were afforded by using 68 % HNO3 and concentrated H2SO4 through controllable synthesis. All the intermediates and the target compounds were confirmed by X‐ray diffraction. It is noteworthy that one of the N‐trinitromethyl nitroimidazole derivatives showed high density (ρ: 1.88 g cm−3), attractive positive oxygen balance (Ω: +18.3 %) and good detonation performance (D: 9003 m s−1) exceeding those of ADN, while N‐nitromethyl derivative behaved higher thermal stability and lower sensitivity in contrast to those of NG. N‐acetate methyl derivative gave an interesting melt‐castable property (Tm.p.: 86 oC, Td: 224 oC), acceptable detonation performance as well as low sensitivity towards impact and friction (IS>40 J, FS>360 N), making it a competitive replacement for DNAN. These chemical and physical properties indicate that these novel materials show promising energetic performance towards future applications.
Head and dental injuries or other dental problems in alpine sports
Authors: Schmid Martina , Schädelin Sabine , Kühl Sebastian , Filippi Andreas 
Published: July 2018

AbstractIn the hectic daily life, spending our leisure time outdoor in the mountains becomes more and more popular. Although information describing dental injuries in various sports is available, data specifically on dental trauma and other dental problems in alpine sports are lacking. Data of 1,128 alpinists were generated by using a standardized questionnaire. The questions focused on the frequency of head and dental injuries and other dental problems. The participating alpinists have been recruited through the network of alpine clubs and an outdoor equipment supplier.Injuries were most frequently caused by a fall while doing alpine sports (14.7%, = 154). Of the participants, 8.2% (n = 93) suffered from a facial injury: 16% (n = 15) of these had a dental trauma. Other dental problems such as barodontalgia were more common than dental traumas. A sensation of pressure or pain was noticed in 13% (n = 135) of the participants at least once. Of all the participants who suffered pain, 54.1% reported one or several previous restorations. Pain medication was beneficial in 92.1%.Dental traumas are rare while doing alpine sports but not negligible because of its requirement of lifelong therapy and incurs substantial treatment costs. An intraoral pain of a usually asymptomatic tissue occurred, in this sample of participants, nearly as often as in pilots and divers. Pain killer is an efficient tool for the alpinists to reduce the pain until they reach a lower altitude.
Clinical performance of LOCATOR® attachments: A retrospective study with 1–8 years of follow‐up
Authors: Guédat Christophe , Nagy Ursina , Schimmel Martin , Müller Frauke , Srinivasan Murali 
Published: July 2018

AbstractThe use of LOCATOR® attachments in implant‐supported removable dental prostheses (ISRDPs) has been evidenced with conflicting clinical behavior in literature. This retrospective study aimed to investigate the long‐term clinical performance of LOCATOR® attachments by evaluating the frequency of the encountered mechanical complication events (MCEs) and the factors that play a role in attachment wear (AW). The study recruited participants with ISRDPs on LOCATOR® attachments. Clinical parameters, number of MCEs (attachment replacements, attachment loosenings, denture cap‐related events, loss of retention and/or insert, and implant fractures), and AW were recorded. Nonparametric tests were applied for statistical analyses (𝛼=0.05). Baseline demographics for the recruited 47 participants (mean age: 72.0 ± 9.0 years) revealed an implant survival rate of 94.9% (mean observation period: 54.8 months), average peri‐implant probing depths, bleeding on probing scores, and plaque scores of 1.80 ± 1.50 mm, 0.70 ± 0.90, and 0.81 ± 0.90, respectively.MCEs were directly influenced by the time in use (p < 0.001). The most frequently encountered MCEs were loss of retention (p < 0.001) and denture cap‐related complications (p = 0.004). AW was found to be significantly higher in the maxilla than in the mandible (p = 0.028); in the maxilla, the vestibular (p = 0.005) and mesial (p = 0.01) aspects were the most common wear sites. Maxillary implant overdentures revealed more vestibular AW (p = 0.013). In prostheses supported by >3 implants, vestibular (p = 0.046) and mesial (p = 0.032) AW were common. Lingual AW (p = 0.021) was observed more frequently when the support was <3 implants. Loss of retention and AW are the most common complications encountered with LOCATOR® attachments. Therefore, a modification in the attachment design along with an amelioration of the attachment surface may help decrease the maintenance needs and further enhance its clinical performance.
Tellurium‐based mass cytometry barcode for live and fixed cells
Authors: Willis Lisa M. , Park Hanuel , Watson Michael W. L. , Majonis Daniel , Watson Jessica L. , Nitz Mark 
Published: July 2018

AbstractMass cytometry is a revolutionary technology that allows for the simultaneous quantification of >40 different biomarkers with cellular resolution. The biomarkers are detected using metal‐labeled antibodies as well as small‐molecule probes of cell size, viability, and biochemical status. Barcoding is an important component of sample preparation because it reduces processing time, eliminates sample‐to‐sample variation, discriminates cell doublets, reduces the amount of antibody needed, and conserves sample. We developed a thiol‐reactive tellurium‐based barcode, TeMal. TeMal is nontoxic at working concentrations, compatible with metal‐labeled antibodies, and can readily be applied to live or fixed cells, making it advantageous and complementary compared to existing barcoding reagents. We have demonstrated the utility of TeMal by barcoding microscale samples in situ to facilitate analysis of cells from an automated cell culture system using mass cytometry.
Integration of firefly optimization and Pearson service correlation for efficient cloud resource utilization
Authors: Gokulraj S. , Geetha B.G. 
Published: July 2018

SummaryCloud Computing (CC) environment presents a simplified, centralized platform or resources to usage while necessitated at minimum cost. In CC, the main processes in is the allocation of resources of web applications. However, with the increasing demands of Cloud User (CU), an efficient resource allocation technique for web applications is required. According to the request made by the user and response obtained, the cost of resources has also to be optimized. To overcome such limitations, Pearson service correlation‐based firefly resource cost optimization (PSC‐FRCO) technique is designed. Pearson service correlation‐based firefly resource cost optimization technique not only improves the performance of cost aware resource allocation but also achieves higher efficiency while rendering services in cloud computing environment for web applications. Pearson service correlation‐based firefly resource cost optimization technique initially uses Pearson service correlation in which the user‐required service is identified by correlating the available services provided by cloud owner. This helps in improving the Response Time (RT) of cloud service provisioning. Next, firefly resource cost optimization algorithm is applied to identify and allocate the cost‐optimized cloud resources to users to afford required service from the cloud server. Thus, PSC‐FRCO technique improves the Resource Utilization Efficiency (RUE) of web applications with minimal computational cost. This technique conducts experimental works on parameters such as RT, Bandwidth Utilization Rate (BUR) computational cost, Energy Consumption (EC), and RUE. Experimental analysis reveals that PSC‐FRCO technique enhances enhances RUE and lessens RT as compared to state‐of‐the‐art works.