bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anxiety Sensitivity as a Risk Indicator for Anxiety, Depression, and Headache Severity in Women With Migraine
Authors: Farris Samantha G. , Burr Emily K. , Abrantes Ana M. , Thomas J. Graham , Godley Frederick A. , Roth Julie L. , Lipton Richard B. , Pavlovic Jelena M. , Bond Dale S. 
Published: June 2019

ObjectiveThe primary aim of this exploratory study was to assess the relationship between anxiety sensitivity and emotional disorders, migraine characteristics, and migraine‐related fear and avoidance behaviors in women with probable migraine.BackgroundAnxiety and depressive disorders are the most frequent comorbid psychiatric conditions in migraine, particularly in women; however, the underlying reasons for these comorbidities are uncertain. Anxiety sensitivity, the tendency to catastrophically appraise anxiety and bodily sensations in terms of their physical, social, or cognitive consequences, is a psychological factor that may contribute to the comorbidity of anxiety and depressive disorders and migraine. It was hypothesized that anxiety sensitivity would be associated with greater migraine severity and psychiatric symptoms.MethodParticipants were women (n = 100) who screened positive for migraine on the validated IDMigraine Screener participated in an anonymous single‐session online survey‐based study on migraine. The Anxiety Sensitivity Index‐3 total and subscales scores were used to assess anxiety sensitivity. Anxiety and depression symptoms were assessed with the brief Patient Health Questionnaire.ResultsOn average, anxiety sensitivity was clinically elevated (mean ± SD: 24.0 ± 15.2). Anxiety sensitivity cognitive and social concerns were most strongly correlated with severity of anxiety (r's = .38‐.46) and depressive symptoms (r = .35‐.39, P's < .001), and all anxiety sensitivity facets were related to fear of head pain (r's = .35‐.38, P's < .001). Anxiety sensitivity cognitive concern facet was uniquely related to headache patterns, including longer migraine attack duration (r = .22, P = .029) and pain intensity (r = .24, P = .029), pain‐related avoidance, including avoiding movement and more frequent misuse of prescribed or non‐prescribed pain medication (r's = .20‐.21, P's < .01).ConclusionsThese novel findings indicate that anxiety sensitivity, specifically fearful appraisal of bodily sensations, are linked to both psychiatric symptoms and migraine severity in women. In this cross‐sectional study, causal sequence cannot be determined. If anxiety sensitivity leads to more severe pain and psychiatric distress, targeting anxiety sensitivity could lead to better headache outcomes.
Conference season
Authors: Grant Maria J. 
Published: June 2019

AbstractHealth library and information workers no longer find themselves restricted to presenting at purely local or national health‐related library events, a diversity evidenced by the two conferences supported by CILIP's Health Libraries Group this month, June 2019. The Health Libraries Group is an official sponsor of #EBLIP10, the 10th international Evidence Based Library and Information Practice conference, which encourages us to think about the evidence we collect and use to inform practice. The Health Libraries Group also strengthens its links with EAHIL: The European Association of Health Information and Libraries by aligning the content of this year's Virtual Issue of the Health Information and Libraries Journal with EAHIL 2019s themes of evidence‐based practice, impact & assessment, and technology uptake, available at: https://bit.ly/2PAZw2X.
Wither health science librarianship? Many questions, many options
Authors: Murphy Jeannette 
Published: June 2019

AbstractThe 2019 virtual issue of the Health Information and Libraries Journal (HILJ) is published to link to the 2019 EAHIL Workshop taking place in Basel, Switzerland on 17‐20 June 2019. The workshop is structured around six topics: (i) Roadmap of our Profession; (ii) Technology Uptake; (iii) Ecology of Scholarly Communications; (iv) Impact + Assessment; (v) Benchmarking + Advocacy; (vi) Evidence‐Based Practice. These themes have been used to compile this virtual issue, which contains published articles selected from HILJ from the March 2019 issue through to June 2017. The virtual issue mirrors the format of a regular issue of HILJ, namely a review article, five original articles and articles from our three regular features: ‘Dissertations into Practice’, ‘International Perspectives and Initiatives’ and ‘Teaching and Learning in Action’. The authors come from the UK, Canada, Australia, Italy, Iran and Belgium. All articles included in this virtual issue are available free online.
Complicated appendiceal diverticulosis versus low‐grade appendiceal mucinous neoplasms: a major diagnostic dilemma
Authors: Lowes Hannah , Rowaiye Babatunde , Carr Norman J , Shepherd Neil A 
Published: June 2019

AimsTo research and identify how often complicated diverticular disease of the appendix [appendiceal diverticular disease (ADD)] shows histological mimicry of low‐grade appendiceal mucinous neoplasms (LAMNs) and to provide guidance on the useful histopathological features that allow the appropriate diagnosis to be made.Methods and resultsSeventy‐four cases of complicated appendiceal diverticular disease were identified from two specialist centres. Of the second opinion/consultation cases, 71% of the ADD cases had been diagnosed by referring pathologists as LAMNs. Salient pathological features were identified and agreed upon to reach the applicable diagnosis. For a diagnosis of complicated diverticulosis, particularly when associated with mucus cysts, the following morphological features were regarded as important: relative retention of the normal mucosal architecture with lamina propria and a maintained crypt architecture, crypts arranged in regular array, epithelial hyperplasia and a lack of nuclear abnormalities extending the length of the crypts. In a formal case–control study undertaken on 30 cases with each diagnosis, ADD and LAMN, loss of lamina propria, a filiform architecture and hypermucinosis were significantly associated with low‐grade appendiceal mucinous neoplasms. Mucosal neuromas were significantly associated with diverticular disease of the appendix.ConclusionsTo our knowledge, this study represents the largest series in the world literature and serves to highlight the important pathological features to distinguish complicated diverticular disease of the appendix from LAMNs, and emphasises the difficulties experienced by diagnostic pathologists in diagnosing complicated appendiceal diverticulosis. This is important, as LAMNs have a significant risk of transcoelomic spread, while complicated appendiceal diverticulosis has no such risk.
Evidence for the Pleistocene persistence of Collembola in Great Britain
Authors: Faria Christiana M. A. , Shaw Peter , Emerson Brent C. 
Published: June 2019

AbstractAimUsing two genera of springtail,LepidocyrtusandEntomobrya(Collembola), we test for genetic signatures of Pleistocene persistence of soil arthropods in Great Britain.LocationGreat Britain.MethodsA region of the mitochondrial cytochrome oxidase I (COI) gene was sequenced for 1,150 Collembola specimens from the generaLepidocyrtusandEntomobryaacross Great Britain. Individuals were clustered into Operational Taxonomic Units (OTUs), and bothOTUrichness and geographical patterns of genetic variation withinOTUs were compared between glaciated and unglaciated areas to identify signatures ofOTUpersistence through Pleistocene glacial events.ResultsOur analyses identified 12Entomobryaand 18LepidocyrtusOTUs in Great Britain.LepidocyrtusOTUrichness was significantly lower in glaciated than unglaciated areas, whereas there was no difference forEntomobryaOTUrichness. However, both genera presented clear patterns of geographically disjunct genetic variation and geographically localized diversification ofOTUs. Estimated dates for the onset of in situ diversification events indicate population persistence that pre‐dates the Last Glacial Maximum.Main conclusionsPatterns of genetic diversity within CollembolaOTUs in Great Britain add to a growing body of evidence that elements of the invertebrate fauna have persisted in situ through Pleistocene glacial cycles. Genetic signatures of population persistence in more northern glaciated areas of Great Britain support a hypothesis of geothermal glacial refugia that call for further investigation with other soil mesofaunal taxa.
Global biogeographic structuring of tropical shallow‐water brittle stars
Authors: Bribiesca‐Contreras Guadalupe , Verbruggen Heroen , Hugall Andrew F. , O'Hara Timothy D. 
Published: June 2019

AbstractAimBiogeographic barriers emerged in the tropical oceans as continental masses moved with plate tectonics, and as the tropics contracted to lower latitudes from the late Eocene. These barriers have shaped tropical marine biodiversity. We characterize large‐scale diversity patterns for tropical brittle stars and investigate the effect of biogeographic barriers on these in space and time.LocationShallow‐water (<200 m) tropical oceans.TaxonTropical shallow‐water brittle stars (class Ophiuroidea).MethodsWe integrate phylogenetic and biogeographic modelling to test and quantify the biogeographic structuring across the major ocean basins for five families of brittle stars. These are well‐sampled in our phylogenies (173 species) and represent an important component of the brittle star fauna of tropical shallow waters. We define major bioregions based on patterns of compositional and phylogenetic beta diversity.ResultsWe find congruence between patterns of shared ancestry of regions and inferred biogeographic histories. Biogeographic reconstructions show that faunal patterns reflect the emergence of biogeographic barriers in the tropical world, with evidence of vicariant events driven by the opening of the Atlantic Ocean, the narrowing of the Tethyan Seaway and the rise of the Isthmus of Panama.Main conclusionsBiogeographic barriers almost completely isolated regional faunas. However, divergence age estimates predate the onset of the different barriers, suggesting that changes associated with the gradual emergence of the barriers had a strong effect on the evolutionary history of tropical shallow‐water brittle stars. Limited, very recent, bi‐directional dispersal was detected across the East Pacific Barrier, which is otherwise an important barrier for dispersal of brittle stars.
Age‐specific characteristics of neutrophilic dermatoses and neutrophilic diseases in children
Authors: Bucchia M. , Barbarot S. , Reumaux H. , Piram M. , Mahe E. , Mallet S. , Balguerie X. , Phan A. , Lacour J.‐P. , Decramer S. , Hatchuel Y. , Jean S. , Begon E. , Joubert A. , Merlin E. , Wallach D. , Meinzer U. , Bourrat E. ,   Groupe de recherche de la Société Française de Dermatologie Pédiatrique; Société Francophone pour la rhumatologie et les Maladies Inflammatoires en Pédiatrie (SOFREMIP)
Published: June 2019

AbstractBackgroundOur suggested ‘modern’ concepts of ‘neutrophilic dermatoses’ (ND) and ‘neutrophilic disease’ were based on observations in adult patients and have not been studied in paediatric patients. Only a minority of ND occurs in children, and little is known about age‐specific characteristics.ObjectivesTo describe age‐specific characteristics of ND in children and to study whether our suggested ‘modern’ classification of ND may be applied to children.MethodsWe conducted a retrospective multicentre study in a French cohort of 27 paediatric patients diagnosed with pyoderma gangrenosum (PG) or Sweet's syndrome (SS).ResultsDemographics and distribution of typical/atypical forms were similar in patients diagnosed with PG and SS. Atypical ND were more frequent in infants (90%), when compared to young children (60%) and adolescents (33%). Neutrophilic disease was observed in 17/27 patients and was most frequent in infants. Neutrophilic disease of the upper respiratory tract, as well as cardiac neutrophilic disease, was only observed in infants, whereas other locations were similarly found in infants, young children and adolescents. In infants and young children, ND were associated with a large spectrum of general diseases, whereas in adolescents associations were limited to inflammatory bowel disease and Behçet's disease.ConclusionsOur study describes the concept of ND in paediatric patients and shows that they have some characteristics different from ND occurring in adults. ND occurring in infants can be associated with a large spectrum of general diseases. Occurrence of neutrophilic disease is frequent in children. Thus, ND occurring in young paediatric patients should incite clinicians to schedule complementary explorations in order to search for involvement of other organs and to rule out monogenetic autoinflammatory syndromes.
Alpha‐synuclein at the nexus of genes and environment: the impact of environmental enrichment and stress on brain health and disease
Authors: Wassouf Zinah , Schulze‐Hentrich Julia M. 
Published: June 2019

AbstractAccumulation of alpha‐synuclein protein aggregates is the hallmark neuropathologic feature of synucleinopathies such as Parkinson’s disease. Rare point mutations and multiplications in SNCA, the gene encoding alpha‐synuclein, as well as other genetic alterations are linked to familial Parkinson’s disease cases with high penetrance and hence constitute major genetic risk factors for Parkinson’s disease. However, the preponderance of cases seems sporadic, most likely based on a complex interplay between genetic predispositions, aging processes and environmental influences. Deciphering the impact of these environmental factors and their interactions with the individual genetic background in humans is challenging and often requires large cohorts, complicated study designs, and longitudinal set‐ups. In contrast, rodent models offer an ideal system to study the influence of individual environmental aspects under controlled genetic background and standardized conditions. In this review, we highlight findings from studies examining effects of environmental enrichment mimicking stimulation of the brain by its physical and social surroundings as well as of environmental stressors on brain health in the context of Parkinson’s disease. We discuss possible internal molecular transducers of such environmental cues in Parkinson’s disease rodent models and emphasize their potential in developing novel avenues to much‐needed therapies for this still incurable disease.
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This article is part of the Special Issue “Synuclein”
Down‐regulation of interleukin‐33 expression in oligodendrocyte precursor cells impairs oligodendrocyte lineage progression
Authors: Sung Hsin‐Yu , Chen Wei‐Yu , Huang Hui‐Ting , Wang Chih‐Yen , Chang Song‐Bin , Tzeng Shun‐Fen 
Published: June 2019

AbstractInterleukin‐33 (IL‐33), a member of the IL1 family, has been found to be expressed in oligodendrocytes (OLGs) and released as an alarmin from injured OLGs to work on other glial cell‐types in the central nervous system. However, its functional role in OLGs remains unclear. Herein, we present that IL‐33 was mainly expressed in the nucleus of CC1+‐oligodendrocytes (OLGs) in mouse and rat corpus callosum, as well as NG2+‐oligodendrocyte precursor cells (OPCs). The in vitro study indicated that the amount of IL‐33 expressing in OPCs was higher when compared to that detected in OLGs. Results from the experiments using lentivirus‐mediated shRNA delivery against IL‐33 expression (IL33‐KD) in OPCs showed that IL33‐KD reduced the differentiation of OLGs into mature OLGs along with the down‐regulation of OLG differentiation‐related genes and mature OLG marker proteins, myelin basic protein (MBP) and proteolipid protein (PLP). Alternatively, we observed reduced differentiation of OLGs that were prepared from the brains of IL‐33 gene knockout (IL33‐KO) mice with anxiolytic‐like behavior. Observations were correlated with the results showing lower levels of MBP and PLP in IL33‐KO cultures than those detected in the control cultures prepared from wildtype (WT) mice. Transmission Electron Microscopy (TEM) analysis revealed that the myelin structures in the corpus callosum of the IL33‐KO mice were impaired compared to those observed in the WT mice. Overall, this study provides important evidence that declined expression of IL‐33 in OPCs suppresses the maturation of OLGs. Moreover, gene deficiency of IL‐33 can disrupt OLG maturation and interfere with myelin compaction.
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Cover Image for this issue: doi: 10.1111/jnc.14522
Natural history of prediabetes in older adults from a population‐based longitudinal study
Authors: Shang Y. , Marseglia A. , Fratiglioni L. , Welmer A.‐K. , Wang R. , Wang H.‐X. , Xu W. 
Published: June 2019

AbstractBackgroundThe natural history of prediabetes in older adults remains unknown.ObjectivesTo assess the rate at which prediabetes progresses to diabetes, leads to death or reverts to normoglycaemia in older adults and to identify prognostic factors related to different outcomes of prediabetes.MethodsIn the Swedish National Study on Aging and Care‐Kungsholmen, 2575 diabetes‐free participants aged ≥60 years were examined at baseline and followed for up to 12 years. At each wave, diabetes was diagnosed via medical examination, antidiabetic drug use, medical records or glycated haemoglobin (HbA1c) ≥6.5%. Prediabetes was defined as HbA1c ≥5.7% and normoglycaemia as HbA1c <5.7% in diabetes‐free participants. Data were analysed with multinomial logistic regression.ResultsAt baseline, 918 (36%) individuals had prediabetes. Of them, 204 (22%) reverted to normoglycaemia (3.4/100 person‐years, 95% CI 5.6–12.3), 119 (13%) developed diabetes (2.0/100 person‐years, 95% CI 1.7–2.4) and 215 (23%) died (13.0/100 person‐years, 95% CI 11.4–14.9) during the 12‐year follow‐up. The rates of reversion, progression and mortality were higher in the first 6‐year than in the second 6‐year follow‐up, albeit not statistically significant. Lower systolic blood pressure (SBP), absence of heart diseases and weight loss promoted the reversion from prediabetes to normoglycaemia, whilst obesity accelerated its progression to diabetes.ConclusionsDuring a 12‐year follow‐up, most of older adults with prediabetes remained stable or reverted to normoglycaemia, whereas only one‐third developed diabetes or died. Lower SBP, no heart diseases and weight management may promote reversion to normoglycaemia, suggesting possible strategies for achieving normoglycaemia in older adults with prediabetes.
Genetic diversity of hop stunt viroid from symptomatic and asymptomatic citrus trees in Iran
Authors: Vamenani Ramtin , Rahimian Heshmatollah , Alavi Seyyed Mohammad , Pakdin Parizi Ali , Mirza Razzaz Tarlan 
Published: June 2019

AbstractHop stunt viroid as the causal agent of cachexia disease has detected from citrus trees in different areas in Iran. Although cachexia has not been reported as a decline disease for citrus trees, it can impair crop quality and reduce plant yields. This study was undertaken to molecularly detect HSVd among different commercial citrus cultivars and determine genetic diversity of this viroid in Mazandaran province of Iran. Sampling was performed from symptomatic and symptomless citrus cultivars in Mazandaran province. HSVd specific primers were used for molecular detection. SSCP and sequencing were applied to assay HSVd genetic diversity. Results showed the detection of HSVd in all symptomatic Satsuma (25 out of 25), Clementine (25 out of 25), sweet lime (20 out of 20) and sweet orange cv. Valencia (7 out of 7), as well as, 31% (14 out of 22), 100% (12 out of 12) and 33% (5 out of 15) of page mandarin, lemon and grapefruit trees, respectively. 10 different HSVd genomes were identified by sequencing the SSCP profiles among which HSVd‐IR1 had the most frequency.
Parallel signaling pathways of pituitary adenylate cyclase activating polypeptide (PACAP) regulate several intrinsic ion channels
Authors: Johnson Gregory C. , May Victor , Parsons Rodney L. , Hammack Sayamwong E. 
Published: June 2019

AbstractPituitary adenylate cyclase activating polypeptide (PACAP), acting through its cognate receptors PAC1, VPAC1, and VPAC2, is a pleiotropic signaling neuropeptide of the vasoactive intestinal peptide/secretin/glucagon family. PACAP has known functions in neuronal growth, development, and repair, and central PACAP signaling has acute behavioral consequences. One of the ways in which PACAP may affect neuronal function is through the modulation of intrinsic membrane currents to control neuronal excitability. Here, we review the evidence of PACAP‐dependent modulation of calcium‐ and voltage‐gated potassium currents, hyperpolarization‐activated cation currents, calcium currents, and voltage‐gated sodium currents. Interestingly, PACAP signaling pathways diverge into parallel pathways to target different ionic currents for modulation, though single pathways are not limited to modulating just one target ionic current. Despite the various targets of modulation, the weight of the evidence suggests that PACAP signaling most commonly leads to a net increase in neuronal excitability. We discuss possible mechanisms by which PACAP signaling leads to the modulation of intrinsic membrane currents that may contribute to changes in behavior.
An Unusual Delayed Onset of Systemic Toxicity After Fluoroscopy‐Guided Cervical Epidural Steroid Injection With Levobupivacaine: A Case Report
Authors: Kang Hee Yong , Kim Jeong Eun , Kim Yun Jong , Park Sung Wook , Kim Youngsoon 
Published: June 2019

AbstractBackgroundCervical epidural steroid injection (CESI) with local anesthetics is commonly used to treat neck pain and radicular pain of the upper extremity. Local anesthetic systemic toxicity (LAST) occurs shortly after injection as a complication; however, delayed onset is a very rare event, especially in central nervous system (CNS) block.Case reportWe present a case in which delayed onset of LAST occurred in a patient who received CESI for cervical and arm radiating pain due to a cervical disc protrusion. We performed the interlaminar approach for CESI using fluoroscopic guidance. After confirming the location of the epidural space using the loss of resistance technique and spreading of contrast agent (Telebrix®30), a mixture of 0.25% levobupivacaine 12.5 mg (5 mL in volume), hyaluronidase 1,500 IU (1 mL), dexamethasone 5 mg (1 mL), and normal saline 3 mL was administrated. After 50 minutes of injection, the patient showed CNS toxicity (unconsciousness, seizure) with normal blood pressure and tachycardia; therefore, she was immediately sedated with intravenous midazolam (3 mg), and 15 L/min of oxygen was administered. The patient fully recovered after 30 minutes of sedation without any sequelae.ConclusionDelayed onset of LAST is a rare complication of a common procedure in CESI, so it is important to be aware of this complication and the presentation of toxicity.