bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimated incidence of adverse reactions to Kampo medicines in randomized controlled clinical trials
Authors: Arai Ichiro , Hagiwara Yuka , Motoo Yoshiharu 
Published: July 2018

ABSTRACTAimJapanese kampo medicines have a long history of empirical use but have not been clinically validated. Therefore, information about the incidence of adverse drug reactions (ADR) is usually lacking. We estimated the incidence of ADR from reports of randomized controlled trials of kampo products.MethodsTrials of kampo products from the evidence reports of the kampo treatment database were examined to determine the number of patients treated with kampo products, and the number and type of ADR.ResultsData for 20 340 users of kampo products were analyzed. Of ≥1000 patients who took kampo products, the proportions of those with ADR were as follows: bakumondoto, 2/2167 patients (0.09%); maobushisaishinto, 8/1201 patients (0.67%); saireito, 21/1131 patients (1.86%); daikenchuto, 5/1131 patients (0.44%); and rikkunshito, 23/1126 patients (2.04%). Five patients (0.02%) developed pseudoaldosteronism; all had received shakuyakukanzoto. Liver injury was reported in 32 patients (0.16%) and was approximately threefold higher in those treated with Scutellaria root formulae (15/4206; 0.36%) than in those treated with non‐Scutellaria formulae (17/16134; 0.11%). Of the Scutellaria root formulae, orengedokuto produced the highest incidence of liver injury (1.97%). No cases of interstitial pneumonia or mesenteric phlebosclerosis were reported. The ADR data for some formulae were similar to data from post‐marketing ADR surveys.ConclusionExamining data from a large number of trials is a useful way of estimating the incidence of kampo medicine ADR.
Gearbox high‐speed‐stage bearing slip induced by electric excitation in a test facility
Authors: Helsen J. , Guo Y. , Keller J. 
Published: July 2018

AbstractThe goal of this paper is to investigate the behaviour of the high‐speed stage of a wind turbine gearbox during transient grid‐loss events triggered at different power levels in a full‐scale nacelle dynamometer test. The gear mesh behaviour and the bearing roller slip during these events are characterized by strain measurements placed in the gear teeth roots and embedded in the outer rings of the tapered roller bearing locating pair. From our experiments, we conclude that the high‐speed stage experiences a multidimensional loading consisting of bending and torsional deformation during the transient event. This loading propagates throughout the gearbox and results in unfavourable loading conditions at the bearing that have the potential to go beyond the preload during the torque reversals that occur during the grid‐loss event. During the torque reversal, roller slip can occur in the bearings. It is observed that the slip behaviour is directly linked to the initial power level of the generator. Electrically induced excitation that typically leads to dynamic torque events can therefore cause mechanical gearbox degradation.
Importance of the nozzle-exit boundary-layer state in subsonic turbulent jets
Authors: Brès Guillaume A. , Jordan Peter , Jaunet Vincent , Le Rallic Maxime , Cavalieri André V. G. , Towne Aaron , Lele Sanjiva K. , Colonius Tim , Schmidt Oliver T. 
Published: July 2018

To investigate the effects of the nozzle-exit conditions on jet flow and sound fields, large-eddy simulations of an isothermal Mach 0.9 jet issued from a convergent-straight nozzle are performed at a diameter-based Reynolds number of $1\times 10^{6}$. The simulations feature near-wall adaptive mesh refinement, synthetic turbulence and wall modelling inside the nozzle. This leads to fully turbulent nozzle-exit boundary layers and results in significant improvements for the flow field and sound predictions compared with those obtained from the typical approach based on laminar flow in the nozzle. The far-field pressure spectra for the turbulent jet match companion experimental measurements, which use a boundary-layer trip to ensure a turbulent nozzle-exit boundary layer to within 0.5 dB for all relevant angles and frequencies. By contrast, the initially laminar jet results in greater high-frequency noise. For both initially laminar and turbulent jets, decomposition of the radiated noise into azimuthal Fourier modes is performed, and the results show similar azimuthal characteristics for the two jets. The axisymmetric mode is the dominant source of sound at the peak radiation angles and frequencies. The first three azimuthal modes recover more than 97 % of the total acoustic energy at these angles and more than 65 % (i.e. error less than 2 dB) for all angles. For the main azimuthal modes, linear stability analysis of the near-nozzle mean-velocity profiles is conducted in both jets. The analysis suggests that the differences in radiated noise between the initially laminar and turbulent jets are related to the differences in growth rate of the Kelvin–Helmholtz mode in the near-nozzle region.
On the spatial segregation of helicity by inertial waves in dynamo simulations and planetary cores
Authors: Davidson P. A. , Ranjan A. 
Published: July 2018

The distribution of kinetic helicity in a dipolar planetary dynamo is central to the success of that dynamo. Motivated by the helicity distributions observed in numerical simulations of the Earth’s dynamo, we consider the relationship between the kinetic helicity, $h=\boldsymbol{u}\boldsymbol{\cdot }\unicode[STIX]{x1D735}\times \boldsymbol{u}$, and the buoyancy field that acts as a source of helicity, where $\boldsymbol{u}$ is velocity. We show that, in the absence of a magnetic field, helicity evolves in accordance with the equation $\unicode[STIX]{x2202}h/\unicode[STIX]{x2202}t=-\unicode[STIX]{x1D735}\boldsymbol{\cdot }\boldsymbol{F}+S_{h}$, where the flux, $\boldsymbol{F}$, represents the transport of helicity by inertial waves, and the helicity source, $S_{h}$, involves the product of the buoyancy and the velocity fields. In the numerical simulations it is observed that the helicity outside the tangent cylinder is predominantly negative in the north and positive in the south, a feature which the authors had previously attributed to the transport of helicity by waves (Davidson & Ranjan, Geophys. J. Intl, vol. 202, 2015, pp. 1646–1662). It is also observed that there is a strong spatial correlation between the distribution of $h$ and of $S_{h}$, with $S_{h}$ also predominantly negative in the north and positive in the south. This correlation tentatively suggests that it is the in situ generation of helicity by buoyancy that establishes the distribution of $h$ outside the tangent cylinder, rather than the dispersal of helicity by waves, as had been previously argued by the authors. However, although $h$ and $S_{h}$ are strongly correlated, there is no such correlation between $\unicode[STIX]{x2202}h/\unicode[STIX]{x2202}t$ and $S_{h}$, as might be expected if the distribution of $h$ were established by an in situ generation mechanism. We explain these various observations by showing that inertial waves interact with the buoyancy field in such a way as to induce a source $S_{h}$ which has the same sign as the helicity in the local wave flux, and that the sign of $h$ is simply determined by the direction of that flux. We conclude that the observed distributions of $h$ and $S_{h}$ outside the tangent cylinder are consistent with the transport of helicity by waves.
It really does take a village: The role of neighbors in the etiology of nonaggressive rule-breaking behavior
Authors: Burt S. Alexandra , Pearson Amber L. , Rzotkiewicz Amanda , Klump Kelly L. , Neiderhiser Jenae M. 
Published: July 2018

AbstractAlthough there is growing recognition that disadvantaged contexts attenuate genetic influences on youth misbehavior, it is not yet clear how this dampening occurs. The current study made use of a “geographic contagion” model to isolate specific contexts contributing to this effect, with a focus on nonaggressive rule-breaking behaviors (RB) in the families’ neighbors. Our sample included 847 families residing in or near modestly-to-severely disadvantaged neighborhoods who participated in the Michigan State University Twin Registry. Neighborhood sampling techniques were used to recruit neighbors residing within 5km of a given family (the mean number of neighbors assessed per family was 13.09; range, 1–47). Analyses revealed clear evidence of genotype–environment interactions by neighbor RB, such that sibling-level shared environmental influences on child RB increased with increasing neighbor self-reports of their own RB, whereas genetic influences decreased. Moreover, this moderation appeared to be driven by geographic proximity to neighbors. Sensitivity analyses further indicated that this effect was specifically accounted for by higher levels of neighbor joblessness, rather than elements of neighbor RB that would contribute to neighborhood blight or crime. Such findings provocatively suggest that future genotype–environment interactions studies should integrate the dynamic networks of social contagion theory.
Setting the Stage: Drama, Libretti and the ‘Invention’ of Opera in Leipzig in the 1680s
Authors: Rathey Markus 
Published: July 2018

AbstractThe opera house in Leipzig opened its doors in 1693. Operas had been performed in central Germany for quite some time but they were primarily confined to courts. With the founding of the opera, Leipzig, home of an important trade fair, provided an additional musical attraction that could entertain merchants coming for the fair. While the year 1693 marks the beginning of regular opera performances in Leipzig, the preceding decades saw an increased interest in dramatic genres in the realms of both secular and sacred music. The connection between these dramatic works and the opera house are not just circumstantial. Some of the key players in the opera business in Leipzig were involved in these earlier pieces as well, especially the poet Paul Thymich, the first librettist for the Leipzig opera, who provided the majority of texts for thedrammi per musica, Singspiels and sacred cantatas.
Reaching the Operatic Stage: The Geographical and Social Origins of British and Irish Opera Singers, c.1850–c.1960
Authors: Russell Dave 
Published: July 2018

AbstractThe backgrounds of opera singers have received little systematic study and this article attempts to help redress this situation through analysis of a collective biography of 344 British and Irish-born performers active in the century from 1850. It argues that certain areas, notably London and Wales, made a particularly significant contribution to the operatic profession and notes that certain other patterns of regional under- and over-production are discernible. While singers from a broadly defined middle class were numerically dominant within this sample, this study stresses the unexpectedly strong contribution from those born into the lower-middle and working classes. Such performers were able to build on skills honed in the amateur musical sphere partly as a result of an expanding state-funded higher education system, but also due to an extraordinary variety of forms of patronage. The ‘popular’ social tone of singers, however, is shown to have done little to challenge perceptions of opera as an elitist cultural form.
The importance of preconception and prenatal genetic evaluation in heart transplant individuals and fetal and postnatal cardiac monitoring in their offspring
Authors: Liu Yin , Bock Matthew J. , Gold June-Anne 
Published: July 2018

AbstractA 24-year-old woman with a history of idiopathic dilated cardiomyopathy status post heart transplant gave birth to a healthy term female infant. At 5 months of age, the infant was diagnosed with severe left ventricular dysfunction with an ejection fraction of 18% and moderate non-compaction of the left ventricle. She received a heart transplant at 7 months of age. Familial dilated cardiomyopathy was diagnosed. Genetic testing revealed a likely pathogenic variant in the TPM1 gene. Fetal cardiac screening is critical for offspring of heart transplant recipients, especially when the reason for transplant was cardiomyopathy. Early genetic consultation and counselling is necessary for all heart transplant recipients, preferably prenatally. Postnatal screening of offspring is essential at birth, at 3-month intervals until 1 year of age, and then annually until the risk for familial cardiomyopathy is assessed.
Food insecurity and anaemia risk: a systematic review and meta-analysis
Authors: Moradi Sajjad , Arghavani Hana , Issah Amos , Mohammadi Hamed , Mirzaei Khadijeh 
Published: July 2018

AbstractObjectiveIncreasing evidence has suggested an association between food insecurity and the risk of anaemia. Therefore, a systematic review and meta-analysis were performed to examine the associations between food insecurity and anaemia risk.SettingPertinent studies were identified by searching PubMed and EMBASE databases up to August 2017. Data were available from nineteen studies; seventeen studies were cross-sectional and two studies were longitudinal. Risk ratios of 95993 individual participants from twelve different countries in these studies were pooled for the meta-analysis.ResultsThe results showed that there was an overall positive relationship between food insecurity and anaemia risk (OR=1·27; 95 % CI 1·13, 1·40). Similar results were observed for Fe-deficiency anaemia (OR=1·45; 95 % CI 1·04, 1·86). These results revealed that food insecurity at two levels, including mild food insecurity (OR=1·15; 95 % CI 1·00, 1·31) and moderate food insecurity (OR=1·36; 95 % CI 1·23, 1·48), increased the risk of anaemia. In addition, it was found that age had an impact on the associations between food insecurity and anaemia risk (OR=1·22; 95 % CI 1·09, 1·36). Age subgroup analysis indicated that food insecurity significantly increased the risk of anaemia among infants/toddlers (OR=1·17; 95 % CI 1·05, 1·29) and adult women (OR=1·35; 95 % CI 1·16, 1·54).ConclusionsIt seems that infants, toddlers and adult women in food-insecure households are at a higher risk of anaemia. To prevent anaemia in food-insecure households, these age groups may require more nutritional support.
Evolutionary Exobiology II: investigating biological potential of synchronously-rotating worlds
Authors: Stevenson David S. 
Published: July 2018

AbstractPlanets that orbit M-class dwarf stars in their habitable zones are expected to become tidally-locked in the first billion years of their history. Simulations of potentially habitable planets orbiting K and G-class stars also suggest that many will become tidally-locked or become pseudo-synchronous rotators in a similar time frame where certain criteria are fulfilled. Simple models suggest that such planets will experience climatic regions organized in broadly concentric bands around the sub-stellar point, where irradiation is maximal. Here, we develop some of the quantitative, as well as the qualitative impacts of such climate on the evolutionary potential of life on such worlds, incorporating the effects of topography and ocean currents on potential biological diversity. By comparing atmospheric circulation models with terrestrial circulation and biological diversity, we are able to construct viable thought models of biological potential. While we await the generation of atmospheric circulation models that incorporate topography and varying subaerial landscape, these models can be used as a starting point to determine the overall evolutionary potential of such worlds. The planets in these thought-models have significant differences in their distribution of habitability that may not be apparent from simple climate modelling.
Cloud Microphysical Factors Affecting Simulations of Deep Convection During the Presummer Rainy Season in Southern China
Authors: Furtado Kalli , Field Paul R. , Luo Yali , Liu Xi , Guo Zhun , Zhou Tianjun , Shipway Benjamin J. , Hill Adrian A. , Wilkinson Jonathan M. 
Published: July 2018

AbstractThe sensitivity of subtropical deep convection to the parameterization of cloud microphysics is elucidated through high‐resolution modeling of extreme presummer rainfall over southern China. An ensemble of physics configuration experiments is used to identify several drivers of model errors in comparison to radar observations from the South China Monsoon Rainfall Experiment (SCMREX) and remotely sensed estimates of cloud, precipitation, and radiation from satellites in the A‐train constellation. The benefits of increasing the number of prognostic variables in the microphysics scheme is assessed, relative to the effects of the parameterization of cloud microphysical properties and cloud fraction diagnosis. By matching individual parameterizations between the microphysical configurations, it is shown that a small subset of the parameterization changes can reproduce most of the dependence of model performance on physics configuration. In particular, biases that are due to the low‐level clouds and rain are strongly influenced by cloud fraction diagnosis and raindrop size distribution, whereas variations in the effects of high clouds are strongly influenced by differences in the parameterization of ice crystal sedimentation. Hence, for the case studied here, these parameterizations give more insight into the causes of variability in model performance than does the number of model prognostics per se.
Land Use‐Dependent Preferential Flow Paths Affect Hydrological Response of Steep Tropical Lowland Catchments With Saprolitic Soils
Authors: Cheng Yanyan , Ogden Fred L. , Zhu Jianting , Bretfeld Mario 
Published: July 2018

AbstractForested catchments in Central Panama can produce more base flow during the dry season compared to pasture catchments—the so‐called “forest sponge effect.” During rainfall events, peak storm runoff rates and storm runoff coefficients can be lower for forested catchments than pasture catchments, even when they have similar topographic characteristics, underlying geology, and soil texture. The internal mechanism of these differences in hydrological response due to land use is yet to be fully understood. A distributed model explicitly simulating preferential flow paths (PFPs), which is referred to as “PFPMod,” is used to explain the hydrological response caused by land use using data from three catchments with distinct land covers in Central Panama. Input parameters of forest and pasture land covers were identified using field observations and literature values. Multiple satisfactory objective criteria demonstrate that the two end‐member land cover parameter sets are adequate to explain the observed difference in dry‐season base flow and storm runoff coefficients. Field measurements of matrix infiltrability using soil cores and plot‐scale infiltration capacity enabled estimating the number of vertical macropores that fully penetrate the root zone. Model simulation results demonstrate that fast drainage through lateral PFPs in the early wet season and high flow in vertical PFPs to recharge deep groundwater in the late wet season contribute to the observed differences in peak storm runoff and the “forest sponge effect” during the dry season. This study provided insights to the mechanism by which reforestation may help to restore ecosystem services and water security in tropical settings.
Cluster Observations of a Dispersive Flapping Event of Magnetotail Current Sheet
Authors: Rong Z. J. , Cai Y. H. , Gao J. W. , Lui A. T. Y. , Shen C. , Petrukovich A. A. , Wei Y. , Wan W. X. 
Published: July 2018

AbstractA kink‐like flapping event of Earth magnetotail current sheet, which consists of two frequency bands successively, is studied by the multipoint observations of Cluster. The multipoint analysis of Cluster observations demonstrates that the higher frequency band (period is about 10 min) has faster propagation velocity (about 30 km/s), shorter wavelength (about 3 RE), and smaller amplitude (1–1.5 RE). In contrast, the lower frequency band (period is about 22 min) shows slower propagation velocity (about 21 km/s), longer wavelength (about 4.4 RE), and larger amplitude (2–3 RE). Comparison with the flapping models demonstrates that the dispersion of theoretical models does not show consistency with the results of this event, which suggests that new or more advanced kink‐like flapping theories or models in the future have to consider the constraints of the dispersive properties demonstrated by this event.
The Meridional Magnetic Field Lines of Saturn
Authors: Carbary J. F. 
Published: July 2018

AbstractThe magnetometer data for the Cassini mission (2004–2016) are used to derive a model of Saturn's meridional magnetic field lines. Using a bin map of the Bρ and Bz field components, the field lines can be traced from the equator to high latitudes in the inner magnetosphere. The traces reveal a magnetic field greatly compressed on the dayside and highly elongated on the nightside, which are presumably the effects of solar wind compression and viscous flow around the magnetosphere. A model of the traced field lines can accommodate this day‐night asymmetry and offer a way to connect various places in the magnetosphere. This model can be adjusted for magnetodisk warping by using solar latitude. The field line traces can be mapped down to the ionosphere using an offset dipole. The dayside magnetopause (L = 21) is mapped to colatitudes of ~13° in the north and ~16° in the south, while for L > 25 on the nightside, the mapped field lines approach asymptotic limits of ~16° in the north and ~18° in the south.
Internal Waves in the Arctic: Influence of Ice Concentration, Ice Roughness, and Surface Layer Stratification
Authors: Cole Sylvia T. , Toole John M. , Rainville Luc , Lee Craig M. 
Published: July 2018

AbstractThe Arctic ice cover influences the generation, propagation, and dissipation of internal waves, which in turn may affect vertical mixing in the ocean interior. The Arctic internal wavefield and its relationship to the ice cover is investigated using observations from Ice‐Tethered Profilers with Velocity and Seaglider sampling during the 2014 Marginal Ice Zone experiment in the Canada Basin. Ice roughness, ice concentration, and wind forcing all influenced the daily to seasonal changes in the internal wavefield. Three different ice concentration thresholds appeared to determine the evolution of internal wave spectral energy levels: (1) the initial decrease from 100% ice concentration after which dissipation during the surface reflection was inferred to increase, (2) the transition to 70–80% ice concentration when the local generation of internal waves increased, and (3) the transition to open water that was associated with larger‐amplitude internal waves. Ice roughness influenced internal wave properties for ice concentrations greater than approximately 70–80%: smoother ice was associated with reduced local internal wave generation. Richardson numbers were rarely supercritical, consistent with weak vertical mixing under all ice concentrations. On decadal timescales, smoother ice may counteract the effects of lower ice concentration on the internal wavefield complicating future predictions of internal wave activity and vertical mixing.