bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of office‐based vergence and anti‐suppression therapy on binocular vision and accommodation in small‐to‐moderate angle intermittent exotropia: A randomised clinical trial
Authors: Ma Martin Ming‐Leung , Kang Ying , Scheiman Mitchell , Chen Qiwen , Ye Xuelian , Pan Liuqing , Deng Jiayu , Su Guangxing , Zhang Guohui , Chen Xiang 
Published: November 2024

AbstractPurposeTo evaluate the short‐term (1 week after completion of treatment) effect of office‐based vergence and anti‐suppression therapy (OBVAT) on binocular vision and accommodative function when compared to observation alone in children with small‐to‐moderate angle intermittent exotropia (IXT).MethodsIn this single‐masked (examiner masked), two‐arm, single‐centre randomised clinical trial, 40 participants, 6 to <18 years of age with untreated IXT were randomly assigned to OBVAT or observation alone. Participants assigned to therapy received 16 weeks of OBVAT (60 min per visit, once per week) with home reinforcement (15 min per day, 5 days a week). Therapy included vergence, accommodation and anti‐suppression techniques. This paper reports the results of clinical measures of binocular vision and accommodation, including fusional vergence, near point of convergence, vergence facility, amplitude of accommodation, the Worth 4‐dot test and the Fusion Maintenance Score (FMS).ResultsTreatment group differences at the primary outcome visit significantly favoured the OBVAT group (n = 20) over the observation group (n = 16) in negative fusional vergence break point at both distance (p ≤ 0.001; r = 0.58) and near (adjusted mean difference: 12.3 Δ; 95% CI: 5.3–19.3 Δ; p = 0.001; partial eta squared: 0.28), positive fusional vergence break point at both distance (p = 0.009; r = 0.43) and near (adjusted mean difference: 20.6 Δ; 95% CI: 11.8–29.4 Δ; p ≤ 0.001; partial eta squared: 0.41), vergence facility (adjusted mean difference: 5.6 cpm; 95% CI: 1.9–9.4 cpm; p = 0.005; partial eta squared: 0.22) and the FMS (p = 0.007; r = 0.44).ConclusionsIn this randomised clinical trial of participants aged 6 to <18 years with IXT, those in the OBVAT group had a significantly better fusional vergence range, vergence facility, near Worth 4‐dot test result and FMS than the observation group at the 17‐week visit. The improvement in these areas further support the effectiveness of OBVAT for improving IXT.
Contraceptive Change and Fertility Transition
Authors: Kantorová Vladimíra , Bongaarts John 
Published: November 2024

AbstractOver the past half‐century, most countries have made progress through their demographic transitions with continuing declines in mortality and fertility. The major driver of fertility decline has been the adoption of contraception by women of reproductive age who increasingly desire smaller families. This paper documents the massive changes in contraceptive behavior that have occurred since 1970 at the global and regional levels and examines contraceptive use differentials by marital status and method. To understand the proximate causes of the rise in contraceptive use, we document the changes in the potential demand for contraception (among women who want to space or limit their childbearing) and the degree to which this potential demand is satisfied by the actual practice of contraception. The paper concludes with a confirmation of the strong inverse relationship between contraceptive use and fertility. The main sources of data for these analyses are comprehensive datasets with country, regional, and global estimates of historical trends in fertility and contraceptive behavior maintained by the Population Division of the United Nations.
Development of Novel InDel Markers for Breeding Applications in Pomegranate (Punica granatum L.)
Authors: Patil Prakash G. , Jamma Shivani M. , N. Manjunatha , K. Dhinesh Babu , Gaikwad Nilesh , Raigond Pinky , P. Shilpa , Murkute Ashutosh A. , Bohra Abhishek , Marathe R. A. 
Published: November 2024

ABSTRACTThe present study aims to enrich the genetic marker resources that are amenable for future trait mapping and quality improvement programmes in pomegranate. We analysed 140 well‐characterized genes that belonged to seven important gene families involved in the growth and development of pomegranate. We retrieved 140 representative genes for seven gene families from four draft genomes of pomegranate, cvs. Tunisia, Dabenzi, Taishanhong and Bhagawa, using BLASTn homology search. A total of 245 InDel primers were designed based on the comparison among four pomegranate genomes for the representative gene sequences, focusing on a size difference of at least 8 base pairs (bp). One hundred forty‐eight (60.41%) markers were in silico verified through e‐PCR on the Tunisia genome and further confirmed on the other three genomes, and we identified 107 polymorphic markers with an average PIC value of 0.62. By using 148 InDel markers physically mapped on the genome, we found that Tunisia had the highest syntenic relations with the Bhagawa (100%), Dabenzi (97.97%) and Taishanhong (97.30%) genomes. Experimental validation of 54 InDel primers on six pomegranate genotypes identified a set of 37 (71.15%) polymorphic markers, 24 of which had PIC values of ≥ 0.48. An investigation on genetic diversity and phenotype correlations in 16 pomegranate genotypes using 16 InDel markers demonstrated the utility of these markers. The developed InDel markers are an excellent resource for diverse applications in pomegranate including genetic diversity, trait mapping, gene discovery and gene editing.
Haploid‐Phased Chromosomal Telomere‐to‐Telomere Genome Assembly of Medicinal Plant Uncaria rhynchophylla Dissects Genetic Controls on the Biosynthesis of Bioactive Alkaloids
Authors: Hu Tao , Duan Lei , Shangguan Liyang , Zhao Qingshi , Hang Ye , Wang Xiaohong , Li Xue , Yang Ningxian , Yan Fulin , Lv Qiuyu , Tang Liu , Liu Miao , Qiang Wei , Wang Xincun , Wang Xuewen , Zhang Mingsheng 
Published: November 2024

ABSTRACTNatural indole alkaloids provide important medicinal resources and defences to environmental stresses. The Uncaria genus is a recorded traditional medicinal woody plant with high alkaloids. Genomic insights into alkaloid variation remain elusive. Here, we have dissected the haploid‐resolved chromosomal T2T genome assembly of Uncaria rhynchophylla with a size of ~634 Mb and contig N50 of 27 Mb using PacBio HiFi long‐reads plus Hi‐C reads and anchored the contigs on 22 pairs of confirmed chromosomes. This genome contains 56% repeat sequences and ~29 000 protein‐encoding genes. U. rhynchophylla diverged from a common ancestor shared with Coffea around 20 million years ago and contains expanded and contracted gene families associated with secondary metabolites and defences/resistance to stresses. We constructed the pathway and mined genes for rhynchophylline alkaloid biosynthesis. Fifty‐three alkaloids in this pathway and eight differentially expressed genes are the keys to alkaloid accumulation. Elevated alkaloid levels are driven by high copy numbers of critical genes STRs and SGRs involved in strictosidine synthesis and hydrolysis as evidenced by phylogenetic, expression and RNA interference analyses. These results advance our genetic understanding and guide further breeding improvements, stress adaptation studies and pharmaceutical development.
MsERF17 Promotes Ethylene‐Induced Anthocyanin Biosynthesis Under Drought Conditions in Malus spectabilis Leaves
Authors: Xu Yaping , Liu Yixin , Yue Lu , Zhang Shuangyu , Wei Jun , Zhang Yuqin , Huang Yuanxing , Zhao Ruiqing , Zou Wenting , Feng Hui , Li Houhua 
Published: November 2024

ABSTRACTDrought is an important factor that affects plant anthocyanin biosynthesis. However, the underlying molecular mechanisms remain elusive. Ethylene response factors (ERFs) are pivotal regulators in plant growth and environmental responses, particularly in anthocyanin biosynthesis. This study investigated the leaf colour transition from green to red in Malus spectabilis under drought conditions. This transition was primarily attributed to the accumulation of anthocyanins, specifically cyanidin‐3,5‐diglucoside and cyanidin‐3‐O‐galactoside. Our findings elucidate the pivotal role of MsERF17 in drought‐induced anthocyanin biosynthesis. Biochemical and molecular analyses showed that MsERF17 positively regulates anthocyanin synthesis by binding to promoters of MsbHLH3 and MsF3′ H, thereby activating their expression. Moreover, transient overexpression and virus‐induced gene silencing of MsERF17 in fruit peel and leaves, respectively, regulated anthocyanin synthesis. The stable transformation of calli further corroborated the positive regulatory function of MsERF17 in anthocyanin biosynthesis. Our results provide novel insights into the mechanism by which MsERF17, induced by ethylene, promotes anthocyanin accumulation through the positive regulation of MsbHLH3 and MsF3'H expression under drought conditions in M. spectabilis leaves.
Safety and Immunogenicity of an FhSAMS Vaccine Against Fasciola hepatica in Dairy Cattle
Authors: Viana Kelvinson Fernandes , Sperandio Natânia do Carmo , Neto Felipe Berbari , Donatele Dirlei Molinari , de Souza Adrieli Barboza , dos Santos Angelo Gabriel Vidal , Rivas Açucena Veleh , Barcellos Ema Carolina de Almeida , Martins Isabella Vilhena Freire 
Published: November 2024

ABSTRACTFasciolosis is a parasitosis of great importance for livestock, as well as for public health, as it is considered by the WHO as a neglected disease. Disease control is complex and reinfections make the use of therapeutic products an unsustainable method from an economic, environmental and health point of view. The aim of this study was to evaluate a new vaccine formulation for dairy cattle, containing soluble Fasciola hepatica antigens associated with Montanide 763 AVG and saponin adjuvants (FhSAMS). The vaccine was tested with two protocols, a single dose and a booster dose 6 months after the first dose. The FhSAMS vaccine proved to be safe, with no side effects. Furthermore, it was able to generate a more robust humoral immune response when a six‐month booster dose was used, in addition to stimulating greater production of IFN‐ʏ, indicating a Th1 profile immune stimulus.
Navigating the hydrogen landscape: An analysis of hydrogen support mechanisms in the US and the EU
Authors: Penttinen Sirja‐Leena 
Published: November 2024

AbstractWhilst hydrogen as a substance is not new, the recent surge in interest around hydrogen is prompting new regulatory frameworks and hydrogen strategies to support the uptake of the hydrogen economy. The potential of hydrogen to facilitate the decarbonisation of especially hard‐to‐abate sectors is immense, and various jurisdictions are actively creating regulatory frameworks for hydrogen investments, particularly in their green, clean or low‐carbon forms. This is crucial because hydrogen's environmental impact depends on its production methods. This article explores the United States (US) and the European Union (EU) approaches in implementing measures to support the uptake of hydrogen market. More specifically, it seeks to identify the main similarities and differences of the forerunner jurisdictions' adopted policies. The article focusses on the recent measures proposed or adopted by both jurisdictions, suggesting that their leading positions are becoming more aligned.
The Effects of FDI on School Enrollment in Developing Countries: New Evidence
Authors: Feldmann Horst 
Published: November 2024

ABSTRACTUsing data on 118 developing countries over the period 1973 to 2019, this paper finds that FDI stocks have positive effects on school enrollment rates. The magnitude of the effects is modest. They are larger at the tertiary than at the secondary level. At both levels of education, females benefit more than males. The paper also explores the channels through which FDI might affect enrollment rates and finds that a well‐developed financial sector enhances the positive effects of FDI on schooling. In contrast to almost the entire literature, the paper uses data on stocks rather than inflows of FDI. FDI stocks are more likely to affect schooling decisions because they are much larger and less volatile than FDI inflows. Indeed, the paper finds that FDI inflows do not affect enrollment rates. Throughout, it accounts for endogeneity of FDI and controls for all major determinants of schooling.
Women's Perspectives on the Unique Benefits and Challenges of Self‐Injectable Contraception: A Four‐Country In‐Depth Interview Study in Sub‐Saharan Africa
Authors: Himes Emily , Suchman Lauren , Kamanga Martha , Birabwa Catherine , Gitome Serah , Omoluabi Elizabeth , Okumu Sarah , Nmadu Grace , Kwena Zachary , Liu Jenny , Challa Sneha , Amongin Dinah , Wekesa Pauline , Ndunyu Louisa , Bukusi Elizabeth , Malata Address , Atuyambe Lynn , Nyando Mandayachepa , Okoli Chioma , Tijani Aminat , Vallin Janelli , Jegede Ayobambo , Dimowo Shakede , Maluwa Alfred , Alitubeera Phoebe , Kaudha Betty , Kayego Agnes , Jumbe Tamandani , Mtalimanja Innocencia , Waiswa Peter , Phillips Beth , Holt Kelsey 
Published: November 2024

AbstractImplementing self‐injection (SI) of subcutaneous depot‐medroxyprogesterone acetate (DMPA‐SC) is a key self‐care strategy for sexual and reproductive health, but SI uptake remains low, and assertions about the potential of SI to increase women's control over contraceptive use lack evidence. We sought to qualitatively explore how women with diverse contraceptive experiences—including those with and without experience using SI—view the benefits and challenges of SI as compared to other methods. We conducted 241 in‐depth interviews with women across four sub‐Saharan African countries and found alignment between the perceived and experienced benefits of SI across our diverse sample. Through the benefits of privacy, easier access, and self‐management, we found SI can promote greater control over the contraceptive experience by facilitating a woman's ability to act on her preferences and control who is involved in or aware of her contraceptive use. Interviews revealed SI's potential is, however, constrained by inherent limitations in the method; for example, it is often not private or accessible enough and many fear injecting themselves. SI has the most potential when implemented with programmatic solutions that mitigate challenges women experience or anticipate and allow more women to benefit from the privacy, easier access, and self‐management that SI offers.
Information frictions and learning dynamics: evidence from tax bunching in Ecuador
Authors: Bohne Albrecht , Nimczik Jan Sebastian 
Published: November 2024

AbstractWe examine how taxpayers learn to minimize personal income tax payments in the context of a rapidly formalizing economy with an expanding tax base. Initially, take‐up of possible generous tax deductions is low among taxpayers in Ecuador who start working in the formal sector. With increasing duration of employment, however, taxpayers become more likely to bunch at the tax exemption threshold using deductions. We exploit rich administrative data on the universe of taxpayers in Ecuador and an event study design to provide causal evidence on the learning mechanisms. We find that the spread of information is driven by the mobility of workers and tax preparers across firms.
El diseño gráfico en la preservación de la memoria del territorio de Usme
Authors: Cristancho Tenjo María Alejandra , Lavao Jorge Yulieth Natalia , Buitrago Gomez Gabriela 
Published: November 2024

El objetivo del artículo es mostrar como el diseño gráfico puede aportar en los entornos sociales, nuevas propuestas para fortalecer los lazos y memorias de una comunidad, tomando como caso de estudio la comunidad de Usme, donde se desarrolló un proyecto de preservación y visualización de la memoria de la comunidad a través del diseño gráfico.
Se presentará un proyecto universitario enfocado en la preservación de la memoria bajo las herramientas que otorga el diseño gráfico como disciplina, dejando de lado su función comercial, crear piezas audiovisuales efectivas e innovadoras que promocionen productos o servicios, crear identidades atractivas que aumenten la visibilidad en el mercado, etc. Para transformaciones sociales considerando la individualidad y vulnerabilidad de los participantes en el proyecto.
Bajo la mano del diseño, se planteó un modo moderno y tangible para comunicar de manera efectiva las memorias de las lideresas del barrio Alfonzo López en Usme, Colombia. El desarrollo de la investigación dio paso a un acercamiento no invasivo a las lideresas permitiendo así un flujo natural para recolectar y entender sus historias y el cómo lograron unificarse y construir un espacio digno a pesar de las dificultades que se presentaron. A través de diversos espacios propuestos se comprendió el desarrollo de su historia para finalmente hacer un libro análogo-digital sobre su recorrido como lideresas en formato de crónica, este libro tiene características especiales (realidad aumentada, medios de comunicación enfocados en el proyecto, personaje 3D, etc.) todo con el fin de hacer más visible su historia tanto para la comunidad como para personas fuera de este contexto.
A Novel Friction Coefficient Model Parameters Identification Method for Needle–Tissue Insertion Procedure
Authors: Hu Yingda , Du Shilun , Li Murong , Xu Tian , Lei Yong 
Published: November 2024

Abstract
In endoscopic liver vascular insertion surgeries, during the process of angiographic operation, the success of vascular staining depends on precise needle insertion control which heavily relies on experienced surgeons. Endoscopic vascular insertion surgical navigation system shows the potential to improve position precision; however, it relies on needle–tissue interaction model and parameter identification to provide essential information for improving needle insertion accuracy, in which the friction coefficient is an important parameter but difficult to determine. In this paper, a novel needle–tissue friction coefficient identification method was proposed with unknown tissue Young's modulus under endoscopic liver surgery scenarios. A modified friction coefficient model was proposed including the adhesion and elastic friction component to describe needle–tissue dynamic interaction process which can predict the friction coefficient more precisely. The proposed parameter estimation method based on the modified friction model can simultaneously estimate friction coefficient and Young's modulus. The proposed method was demonstrated by the friction coefficient measurement experiment. The results showed that the friction coefficient model prediction results agreed well with expected value. The proposed method can be applied to provide essential tissue-needle interactive information to improve needle insertion precision in endoscopic liver vascular insertion surgery scenarios.
Motherhood and Sexuality in Women’s Football News: Effects on Interest in the Article, Engagement, and Perception of the Player
Authors: Rodríguez-de-Dios Isabel , González-de-Garay Beatriz 
Published: November 2024

Women’s football has gained popularity and appreciation in the last few years. At the same time, sexual diversity and maternity in sport have become part of the global conversation. To investigate the influence of players’ motherhood and sexuality in the context of news, a 2 (sexuality) × 2 (motherhood status) between-subjects online experiment (N = 395) was conducted. The research examined the impact on interest in the news article, women’s football engagement, perception of the footballer (i.e., expected performance, impression, and perceived commitment), and attitudes toward lesbian athletes. Results show that featuring the footballer as a mother increased interest in the article. However, the maternity status had a negative impact only on the perception of the lesbian footballer, who was expected to show lower performance compared with her counterparts. These findings may help journalists and community managers to understand the impact and the ethical implications of their work.
Return-to-Play With R2Play: Protocol for Evaluating Cross-Site Feasibility, Face Validity, and Content Validity of a Multidomain Concussion Assessment Tool for Youth
Authors: Scratch Shannon , Shore Josh , DuPlessis Danielle , Lovell Andrew , Hickling Andrea , Gill Pavreet , Mallory Kylie , Lam Emily , Hotze Fanny , Zemek Roger , Emery Carolyn , Schneider Kathryn , Hutchison Michael , Gagnon Isabelle , Caron Jeffrey , Reed Nick , Biddiss Elaine 
Published: November 2024

Context: Clinical concussion assessments do not typically simulate the speed or complexity of sport. Performance changes arising from combined physical, cognitive, and sensory demands of sport may thus remain undetected during rehabilitation. We developed R2Play, a multidomain return-to-play assessment tool for youth with concussions. R2Play involves levels and conditions that vary in physical, cognitive, and sensory load to simulate the multidomain demands of sport. Objectives: To explore cross-site feasibility, face validity, and content validity of R2Play by integrating quantitative and qualitative data. Methods: Convergent mixed-methods feasibility study. Five sites will each recruit 5 clinicians (total nc = 25) and 10 youth sport participants (ages 10–25 y) with a history of concussion in the previous year (total ny = 50). Feasibility will be evaluated using quantitative criteria for acceptability, demand, implementation, practicality, and integration, and qualitative investigated data from content analysis of postassessment interviews with youth and clinician participants. Face validity will be investigated in postassessment interviews. Content validity will be established through (1) changes in performance metrics (time to completion, errors, and heart rate) across R2Play levels, (2) youth-perceived physical and cognitive exertion for each level, and (3) overall clinician perceptions determined through postassessment interviews. Qualitative and quantitative data will be merged through joint display to identify areas of convergence, divergence, and complementarity, and to establish meta-inferences about feasibility, face validity, and content validity. Discussion: This study aims to demonstrate the face and content validity of R2Play, and its feasibility for cross-site implementation. Findings will guide further iteration of R2Play and establish the foundation for a larger multicenter validation study to establish the psychometric properties of R2Play. This work represents an important first step toward the implementation of an ecologically valid multidomain assessment tool designed to support a safe and efficient return-to-play after concussion, ultimately reducing the risk of recurrent concussion and subsequent injury.
Complete genome sequence of
Cronobacter sakazakii
ES191 generated by PacBio sequencing
Authors: Wu Shuyan , Jauregui Ruy , Maclean Paul , Brightwell Gale 
Published: November 2024

ABSTRACT

We present the complete genome of
Cronobacter sakazakii
ES191, isolated from New Zealand in 2011 and known for its strong biofilm ability. The genome consists of a 4,309,604-base pair (bp) circular chromosome (56.9% GC) and a 165,613-bp circular plasmid (55.4% GC).