bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED: Long non‐coding RNA LOC554202 promotes laryngeal squamous cell carcinoma progression through regulating miR‐31
Authors: Yang Shujuan , Wang Jing , Ge Wensheng , Jiang Yanfang 
Published: May 2018

AbstractLaryngeal squamous cell carcinoma (LSCC) is one aggressive malignancy and accounts for 20% of all head and neck cancer. However, the role of LOC554202 in human LSCC remains unknown. The expression level of LOC554202 and miR‐31 was detected in the LSCC tiussues by using qRT‐PCR. Cell growth was measured by CCK‐8 assay. Flow cytometry and matrigel‐coated membrane was used to detect for cell cycle and invasion respectively. We indicated that lncRNA LOC554202 expression was overexpressed in LSCC tissues compared with the paired adjacent samples and higher LOC554202 expression was associated with the advanced stage. In addition, we demonstrated that the expression level of miR‐31 was downregulated in LSCC tissues compared to the paired adjacent samples and lower miR‐31 expression was correlated with the advanced stage. Moreover, the expression of miR‐31 was negatively correlated with the expression of LOC554202 in LSCC tissues. Ectopic expression of LOC554202 promoted LSCC cell growth, cell cyle and cell invasion and overexpression of miR‐31 inhibited LSCC cell growth, cell cyle and cell invasion. Elevated expression of LOC554202 suppressed miR‐31 expression and promoted RhoA expression in LSCC cell, which was a direct target gene of miR‐31. Furthermore, LOC554202 increased LSCC cell growth, cell cyle and cell invasion through suppressing miR‐31 expression. These results suggested that LOC554202 acted as an oncogene in the development of LSCC.
Notch signaling promotes angiogenesis and improves cardiac function after myocardial infarction
Authors: Zhou Xue‐liang , Zhu Rong‐rong , Liu Sheng , Xu Hua , Xu Xinping , Wu Qi‐cai , Liu Ji‐chun 
Published: May 2018

AbstractCurrently, the role of Notch signaling during myocardial infarction (MI) remains controversy. In this study we used in vitro and in vivo approaches to investigate the role of Notch signaling in MI. Using cultured human umbilical vein endothelial cells exposed to hypoxia/reoxygenation (H/R), we demonstrated that H/R inhibited the proliferation, VEGF secretion, and tube formation of HUVECs, and these effects were correlated with the inhibition of Notch signaling. Furthermore, these effects were antagonized by overexpression of NICD but aggravated by knockdown of NICD. In addition, in MI model rats we found that heart dysfunction and angiogenesis in model rats was partly improved by NICD overexpression but was aggravated by knockdown of NICD. In conclusion, these data demonstrate that Notch signaling is downregulated in H/R injury in the hearts. Artificial activation of Notch signaling could promote myocardial survival and angiogenesis and improve cardiac function following H/R injury.
Genotype I hepatitis A virus introduction in Italy: Bayesian phylogenetic analysis to date different epidemics
Authors: Cella Eleonora , Riva Elisabetta , Angeletti Silvia , Fogolari Marta , Blasi Aletheia , Scolamacchia Vittoria , Spoto Silvia , Bazzardi Riccardo , Lai Alessia , Sagnelli Caterina , Sagnelli Evangelista , Ciccozzi Massimo 
Published: May 2018

Despite a significant decrease in acute hepatitis A in the last 2 decades in Italy, outbreaks were observed occurring mostly in southern Italy. In this study, Bayesian phylogenetic analysis was used to analyze the origin of these epidemics. With this aim, 5 different data sets of hepatitis A virus sequences were built to perform genotyping by the neighbor‐joining method to estimate the evolutionary rates by using a Bayesian Markov chain Monte Carlo approach and to investigate the demographic history by independent Markov chain Monte Carlo runs enforcing both a strict and relaxed clock. The estimated mean value of the evolutionary rate, representing Ia and Ib strains, was 1.21 × 10−3 and 2.0 × 10−3 substitutions/site/year, respectively. The Bayesian maximum clade credibility tree of hepatitis A virus (HAV) Ia and Ib strains showed that Italian sequences mostly formed separate clusters. The root of the time for the most recent common ancestor (tMRCA) for HAV Ia and Ib strains dated back to 1981 and to 1988, respectively, showing in both cases different epidemic entrances. Phylodynamic analysis showed that genotype Ia increased in 1997, when the Apulia epidemic started, then suffered a bottleneck, probably consequent to vaccination and to the herd immunity, followed by a new increase in virus population in the years 2013‐2014 consequent to the epidemic caused by the ingestion of mixed frozen berries. A similar trend without an evident bottleneck was observed also in the case of genotype Ib. In conclusion, the Bayesian phylogenetic analysis represents a good tool to measure the effectiveness of the public health plans used for HAV control.
Development of a peptide substrate for detection of sunn pest damage in wheat flour
Authors: Hançerlioğulları Begüm Zeynep , Köksel Hamit , Dudak Fahriye Ceyda 
Published: May 2018

AbstractBACKGROUNDSince the common protease substrates did not give satisfactory results for the determination of Sunn pest protease activity in damaged wheat, different peptide substrates derived from the repeated sequences of high molecular weight glutenin subunits were synthesized.RESULTSHydrolysis of peptides by pest protease was determined by high‐performance liquid chromatography. Among three peptides having the same consensus motifs, peptide1 (PGQGQQGYYPTSPQQ) showed the best catalytic efficiency. A novel assay was described for monitoring the enzymatic activity of protease extracted from damaged wheat flour. The selected peptide was labeled with a fluorophore (EDANS) and quencher (Dabcyl) to display fluorescence resonance energy transfer. The proteolytic activity was measured by the change in fluorescence intensity that occurred when the protease cleaved the peptide substrate. Furthermore, the assay developed was modified for rapid and easy detection of bug damage in flour. Flour samples were suspended in water and mixed with fluorescence peptide substrate. After centrifugation, the fluorescence intensities of the supernatants, which are proportional to the protease content of the flour, were determined.CONCLUSIONThe total analysis time for the assay developed is estimated as 15 min. The assay developed permits a significant decrease in time and labor, offering sensitive detection of Sunn pest damage in wheat flour. © 2018 Society of Chemical Industry
Characterization of electronic displays using CMOS single‐photon avalanche diode image sensors
Authors: Mai Hanning , Gyongy Istvan , Dutton Neale A.W. , Henderson Robert K. , Underwood Ian 
Published: May 2018

AbstractAdvanced complementary metal‐oxide semiconductor‐compatible single‐photon avalanche diode array technology is progressing rapidly and is being deployed in a wide range of applications. We report for the first time the use of a complementary metal‐oxide semiconductor‐compatible single‐photon avalanche diode array to perform detailed optical measurements on pixels of an organic light‐emitting diode microdisplay at very high sampling rate, very low light level, and over a very wide dynamic range of luminance. This offers a clear demonstration of the huge potential of this single‐photon avalanche diode technology to reveal hitherto obscure details of the optical characteristics of individual and groups of organic light‐emitting diode pixels.
The role of industry influence in sinus balloon dilation: Trends over time
Authors: Gadkaree Shekhar K. , Rathi Vinay K. , Gottschalk Esther , Feng Allen L. , Phillips Katie M. , Scangas George A. , Metson Ralph 
Published: May 2018

ObjectiveBalloon dilation (BD) is a controversial alternative to conventional sinus surgery. The role of industry on practice patterns remains unknown. The aim of this study was to determine whether industry payments from BD manufacturers influence practice patterns for otolaryngologists and evaluate how these payments change over time.MethodsRetrospective cohort study using Medicare Provider Utilization and Payment (PUP) Data and Center for Medicare and Medicaid Services Open Payments (OP) general payment datasets. A total of 294 otolaryngologists identified in the PUP dataset who performed BD procedures from January 1, 2013, to December 31, 2015, were cross‐referenced in the OP dataset from January 1, 2014, to December 31, 2016, for BD manufacturer payments. Payments to surgeons performing BD stratified by amount, type, and number of procedures performed were primary outcome measures.ResultsOf the 294 otolaryngologists reporting BD procedures, 223 (76%) received payments from a company that manufactures BD devices. Receipt of $2,500 in BD payments was associated with performance of one additional BD procedure, and consulting fees were most positively associated with performing additional BD procedures (P = 0.006). The providers receiving the most in BD payments were more likely to continue to receive the most in payments, regardless of number of BD procedures performed. Performing more BD procedures did not correlate with decrease in other sinus procedures.ConclusionPayments to otolaryngologists from manufacturers of sinus BD devices are associated with the performance of an increased number of such procedures. Surgeons should consider the impact of interactions with industry when evaluating patients for BD procedures.Level of Evidence4. Laryngoscope, 128:1540–1545, 2018
Effects of seasonal variability of climatic factors on vegetation coverage across drylands in northern China
Authors: Zhang Jutao , Zhang Yuqing , Qin Shugao , Wu Bin , Wu Xiuqin , Zhu Yakun , Shao Yanying , Gao Yan , Jin Qiutong , Lai Zongrui 
Published: May 2018

AbstractThe relationships between vegetation and climatic factors are extremely complex and nonlinear. To identifying these relationships across the drylands in northern China, we analysed the driving effects of air temperature, precipitation, actual evapotranspiration, and reference crop evapotranspiration (i.e., potential evapotranspiration) on the seasonal variability of the leaf area index (LAI) in various locations including Horqin, Hulun Buir, Otindag, Mu Us, Tengger, and Junggar by using convergent cross mapping and multivariate empirical dynamic modelling based on meteorological datasets of 421 stations and remote sensing datasets at 8‐day intervals during 2000 to 2014. Over the study period, the strengths of the driving effects of the climatic factors on LAI were related to their own seasonality. Except in Junggar, the sensitivity of LAI to the climatic factors weakened with decreases in the aridity index, and these relationships changed over different seasons, but LAI was most vulnerable to the effects of climatic factors in the early growing season. Our results show that vegetation in the eastern drylands (e.g., Horqin, Hulun Buir, and Otindag) of northern China is more sensitive to seasonal climatic variations than that in the western drylands (e.g., Mu Us and Tengger), which suggests that vegetation in the eastern drylands may face greater risks of degradation under climate change. On the basis of our results, we recommend the application of differential management strategies for the drylands in northern China to prevent ongoing desertification and to achieve the target of land degradation neutrality by 2030.
Balancing organic carbon supply and consumption in the ocean's interior: Evidence from repeated biogeochemical observations conducted in the subarctic and subtropical western North Pacific
Authors: Uchimiya Mario , Fukuda Hideki , Wakita Masahide , Kitamura Minoru , Kawakami Hajime , Honda Makio C. , Ogawa Hiroshi , Nagata Toshi 
Published: May 2018

AbstractThe heterotrophic prokaryotic carbon demand (PCD) in the ocean's interior often substantially exceeds (by up to two orders of magnitude) the amount of organic carbon supplied by sinking particulate organic carbon (POC). A hypothesis to explain this carbon imbalance proposes that some non‐steady‐state processes have not been considered in previous studies based on snapshot data. To test this hypothesis, we collected time‐series (2.5 yr) data on sinking POC fluxes using moored sediment traps (trap deployment depths: 200 m, 500 m, and 4810 m) and compared them with the PCD data collected seasonally at two stations in the subarctic and subtropical western North Pacific. The POC supplies (ΔPOC) in the 200–500 m and 500–4810 m layers were estimated with a correction, when appropriate, for the non‐steady‐state effect arising from the change in the POC flux during the transit of POC between the upper and deeper traps. In the 200–500 m layer, ΔPOC generally exceeded or equaled PCD. In contrast, in the 500–4810 m layer, PCD generally exceeded ΔPOC by up to sevenfold. However, on a yearly basis, this carbon imbalance in the deeper layer decreased, with PCD balancing ΔPOC within a factor of 2. Therefore, the enigma of the high PCD relative to the POC flux in deep water is partially resolved by assuming a temporal uncoupling between supply and consumption, which partly equilibrates the carbon budget over a longer (yearly) time scale.
Poly(2‐oxazoline) Hydrogels: State‐of‐the‐Art and Emerging Applications
Authors: Dargaville Tim R. , Park Jong‐Ryul , Hoogenboom Richard 
Published: May 2018

AbstractThe synthesis of poly(2‐oxazoline)s has been known since the 1960s. In the last two decades, they have risen in popularity thanks to improvements in their synthesis and the realization of their potential in the biomedical field due to their “stealth” properties, stimuli responsiveness, and tailorable properties. Even though the bulk of the research to date has been on linear forms of the polymer, they are also of interest for creating network structures due to the relatively easy introduction of reactive functional groups during synthesis that can be cross‐linked under a variety of conditions. This opinion article briefly reviews the history of poly(2‐oxazoline)s and examines the in vivo data on soluble poly(2‐oxazoline)s to date in an effort to predict how hydrogels may perform as implantable materials. This is followed by an overview of the most recent hydrogel synthesis methods and emerging applications, and is concluded with a section on the future directions predicted for these fascinating yet underutilized polymers.
Pain processing in functional and idiopathic dystonia: An exploratory study
Authors: Morgante Francesca , Matinella Angela , Andrenelli Elisa , Ricciardi Lucia , Allegra Cosimo , Terranova Carmen , Girlanda Paolo , Tinazzi Michele 
Published: May 2018

ABSTRACTBackground: Pain is often experienced by patients with functional dystonia and idiopathic cervical dystonia and is likely to be determined by different neural mechanisms.Objective: In this exploratory study, we tested the sensory‐discriminative and cognitive‐emotional component of pain in patients with functional and idiopathic dystonia.Methods: Ten patients with idiopathic cervical dystonia, 12 patients with functional dystonia, and 16 age‐ and sex‐matched healthy controls underwent psychophysical testing of tactile and pain thresholds and pain tolerance. We delivered electrical pulses of increasing intensity to the index finger of each hand and the halluces of each foot. Pain threshold and pain tolerance were respectively defined as the (1) intensity at which sensation changed from unpainful to faintly painful and (2) intensity at which painful sensation was intolerable.Results: No differences were found between the three groups for tactile and pain thresholds assessed in hands and feet. Pain tolerance was significantly increased in all body regions only in functional dystonia. Patients with continuous functional dystonia had higher pain tolerance compared to subjects with paroxysmal functional dystonia and idiopathic cervical dystonia. There was no correlation between pain tolerance and pain scores, depression, anxiety, disease duration, and motor disability in both groups.Conclusions: Patients with functional dystonia have a dissociation between the sensory‐discriminative and cognitive‐emotional components of pain, as revealed by normal pain thresholds and increased pain tolerance. Abnormal connectivity between the motor and limbic systems might account for abnormal pain processing in functional dystonia. © 2018 International Parkinson and Movement Disorder Society
Low‐cost metamaterial absorber using three‐dimensional circular truncated cone
Authors: Yoon Youngseo , Lim Daecheon , Tentzeris Manos M. , Lim Sungjoon 
Published: May 2018

AbstractIn this article, we propose a low‐cost three‐dimensional (3D) printed metamaterial absorber. The proposed metamaterial consists of a periodic structure of circular truncated cones. The dielectric materials supporting the circular truncated cone are made from a poly(lactic acid) filament using the 3D printer. The conductor of the circular truncated cone is developed by spraying silver‐coated copper. The performance of the proposed absorber is numerically and experimentally investigated. The simulated and measured absorptivity are 91% and 95% at 10.8 and 10.81 GHz, respectively. As a result of the 3D printing and silver spray coating processes, the proposed absorber can be easily fabricated at a low cost.
Substrate‐integrated waveguide based antenna in remote respiratory sensing
Authors: Muharram Bushra , Okoniewski Michal 
Published: May 2018

AbstractContinuous respiratory monitoring is important in a hospital environment. It has the potential to reduce mortality in central sleep apnea. Remote monitoring can be achieved using electromagnetic waves. A leaky‐wave array antenna using substrate‐integrated waveguide technology is proposed in remote respiratory sensing. It operates between 8 and 9 GHz and offers inexpensive beam‐scanning ability to scan a hospital bed and locate patient's chest for monitoring. The proposed antenna is also tested in detecting simulated chest movements manifested as phase variations of back reflected signal and converted to displacement data.
A microring conjugate mirror design and simulation for naked‐eye 3D imaging application
Authors: Pornsuwancharoen N. , Youplao P. , Tamee K. , Amiri I. S. , Ali J. , Singh G. , Yupapin P. , Suhailin F. H. , Cacha L. A. , Poznanski R. R. 
Published: May 2018

AbstractWe present a design of micro‐conjugate mirror using a nonlinear microring resonator, which is made of GaAsInP/P, is rapidly achieving widespread option in several three‐dimensional (3D) imaging applications. By exploiting the conjugate mirror properties, the 3D light probes can be formed by the whispering gallery modes (WGM) in which the WGM probe is also available within a nonlinear microring resonator. It is important to understand, these light probes use the similar functional principle to provide structured light through the object, just as the reference beams to light up and develop a hologram using the holographic method. The interference of 2 beams constructs the 3D image which can be seen by the naked‐eye while providing the 3D perception. The simulation results obtained from the transmission of 3D imaging are processed using MATLAB and OptiFDTD are compared and analyzed. These convincing theoretical results suggest that the proposed method can be used in practice to realize the naked‐eye 3D imaging with convincing visual perception and efficient transmission while providing the ultimate mode of convenience for viewers.
Tightly arranged orthogonal mode antenna for 5G MIMO mobile terminal
Authors: Sun Libin , Feng Haigang , Li Yue , Zhang Zhijun 
Published: May 2018

AbstractThis letter presents an orthogonal mode 4‐antenna system operating in the 3.5‐GHz band (3.3–3.6 GHz) for the fifth‐generation (5G) multiple‐input multiple‐output (MIMO) mobile device. The 4‐antenna system is composed of 2 identical tightly arranged antenna pairs, and each pair is formed with an arrow‐shaped monopole and a bended dipole with gap‐coupled feeding. The tightly‐arranged antenna pair is face‐to‐face arranged on the front and back side of the substrate and the distance between the center of the 2 elements is only 1 mm; however, they have good isolation (better than 10 dB) and diversity performance (envelope correlation coefficient better than 0.11) with the help of orthogonal mode. This configuration provides promising solution for compactness of the MIMO antenna in mobile phone. The prototype was fabricated and measured, and the measured results show good agreements with the simulated ones.
A stretchable smart and highly efficient radio frequency antenna on low cost substrate
Authors: Deepa Nivethika S. , Sreeja B. S. , Manikandan E. , Radha S. 
Published: May 2018

AbstractThe manufacture and characterization of highly efficient smart antenna with stretchable behavior for C band wireless applications is described. The smart antenna uses stretchable substrate as well as stretchable patch. Ag elastomer is used as conductive and ethyl vinyl acetate is used as dielectric substrate for elastic applications. The exactness in antenna manufacture is achieved by utilizing corelDraw software. It is shown that, frequency reconfigures by varying the strain and can withstand up to 25% strain with relatively good efficiency. Furthermore, the results indicate that the antenna parameters with respect to no strain, 10% strain and 23% strain are simulated using HFSS and are found to be in match with the measured results.
Closely spaced MIMO antenna based on substrate‐integrated waveguide technology
Authors: Sung Youngje 
Published: May 2018

AbstractIn this letter, a compact array system for multiple‐input‐multiple‐output (MIMO) applications is designed, based on substrate integrated waveguide (SIW) technology. In order to verify the potential of the proposed antenna as a MIMO application, 2 types of 4‐element SIW antenna are placed in a compact space. Four isosceles triangle (type 1) and rectangle (type 2) SIW antennas, consisting of metallic vias at 1 side and slit at the other side, are used as radiating elements. The side‐to‐side distance of the elements is only 0.006 λ0. The peak gain of these patterns is −3 dBi. The envelope correlation coefficient is calculated from the measured 3D patterns and shows good MIMO performance. The proposed antenna achieves both a significant reduction of size and mutual coupling by metallic vias.
Comment on “a compact ultra‐thin ultra‐wideband microwave metamaterial absorber”
Authors: Marathe Dushyant Subhash , Kulat Kishore 
Published: May 2018

AbstractIn the recently published article, Ramya et al. (Microw Opt Technol Lett. 2017;59:1837–1845. https://doi.org/10.1002/mop.30636) proposed asymmetrical metamaterial absorber structure for wideband applications. It was shown that, the reported structure has wideband absorptivity (above 85%) from 10.36 to 16.67 GHz. It is demonstrated in this article that, the reported unit cell is not a metamaterial electromagnetic wave absorbing structure. It is found that, peak absorptivity is 37.6%, 26.5%, and 28.6% at frequencies 10.5, 13.9, and 16.2 GHz, respectively. The strong wideband absorption caused in the original article is due to ignorance of cross‐polarized reflections in the calculation of absorbivity rather than true absorption as authors claimed.