bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diversity and convergence of mechanisms involved in pyrethroid resistance in the stored grain weevils, Sitophilus spp.
Authors: Haddi Khalid , Valbon Wilson R. , Viteri Jumbo Luis O. , de Oliveira Luiz O. , Guedes Raul N. C. , Oliveira Eugenio E. 
Published: October 2018

AbstractTarget-site mutations and changes in insect metabolism or behavior are common mechanisms in insecticide-resistant insects. The co-occurrence of such mechanisms in a pest strain is a prominent threat to their management, particularly when alternative compounds are scarce. Pyrethroid resistance among stored grain weevils (i.e., Sitophilus spp.) is an example of a long-standing concern, for which reports of resistance generally focus on a single mechanism in a single species. Here, we investigated pyrethroid resistance in maize and rice weevils (i.e., Sitophilus zeamais and S. oryzae), exploring potential knockdown resistance (kdr) mutations in their sodium channels (primary site for pyrethroid actions) and potential changes in their detoxification and walking processes. Resistance in pyrethroid-resistant rice weevils was associated with the combination of a kdr mutation (L1014F) and increases in walking and detoxification activities, while another kdr mutation (T929I) combined with increases in walking activity were the primary pyrethroid resistance mechanisms in maize weevils. Our results suggest that the selection of pyrethroid-resistant individuals in these weevil species may result from multiple and differential mechanisms because the L1014F mutation was only detected in Latin American rice weevils (e.g., Brazil, Argentina and Uruguay), not in Australian and Turkish rice weevils or Brazilian maize weevils.
Receptor-Ligand Interaction Mediates Targeting of Endothelial Colony Forming Cell-derived Exosomes to the Kidney after Ischemic Injury
Authors: Viñas Jose L. , Spence Matthew , Gutsol Alex , Knoll William , Burger Dylan , Zimpelmann Joseph , Allan David S. , Burns Kevin D. 
Published: October 2018

AbstractEndothelial colony forming cell (ECFC)-derived exosomes protect mice against ischemic kidney injury, via transfer of microRNA-(miR)-486-5p. Mechanisms mediating exosome recruitment to tissues are unclear. We hypothesized that ECFC exosomes target ischemic kidneys, involving interaction between exosomal CXC chemokine receptor type 4 (CXCR4) and stromal cell-derived factor (SDF)-1α. Ischemia-reperfusion was induced in mice by bilateral renal vascular clamp, with intravenous infusion of exosomes at reperfusion. Optical imaging determined exosome biodistribution, and miR-486-5p was measured by real-time PCR. Human umbilical vein endothelial cells (HUVECs) were cultured to study the CXCR4/SDF-1α interaction. Targeting of administered exosomes to ischemic kidneys was detected 30 min and 4 hrs after reperfusion. Exosomes increased miR-486-5p levels only in kidneys, within proximal tubules, glomeruli, and endothelial cells. Uptake of fluorescently-labeled exosomes into HUVECs, and exosomal transfer of miR-486-5p were enhanced by hypoxia, effects blocked by neutralizing antibody to SDF-1α or by the CXCR4 inhibitor plerixafor. Infusion of ECFC exosomes prevented ischemic kidney injury in vivo, an effect that was not observed when exosomes were pre-incubated with plerixafor. These data indicate that ECFC exosomes selectively target the kidneys after ischemic injury, with rapid cellular transfer of miR486-5p. Targeting of exosomes may involve interaction of CXCR4 with endothelial cell SDF-1α.
Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells
Authors: Oba Shigeyoshi , Ayuzawa Nobuhiro , Nishimoto Mitsuhiro , Kawarazaki Wakako , Ueda Kohei , Hirohama Daigoro , Kawakami-Mori Fumiko , Shimosawa Tatsuo , Marumo Takeshi , Fujita Toshiro 
Published: October 2018

AbstractEpigenetic modulation may underlie the progression of diabetic nephropathy (DN). Involvement of TGFB1 in mesangial fibrosis of DN led us to hypothesize that Tgfb1 DNA demethylation contributes to progression of DN. In primary mesangial cells from diabetic (db/db) mouse kidneys, demethylation of Tgfb1 DNA and upregulation of Tgfb1 mRNA progressed simultaneously. USF1 binding site in Tgfb1 promoter region were demethylated, and binding of USF1 increased, with decreased binding of DNMT1 in db/db compared with control. Given downregulation of Tgfb1 expression by folic acid, antioxidant Tempol reversed DNA demethylation, with increased and decreased recruitment of DNMT1 and USF1 to the promoter, resulting in decreased Tgfb1 expression in db/db mice. Addition of H2O2 to mesangial cells induced DNA demethylation and upregulated Tgfb1 expression. Finally, Tempol attenuated mesangial fibrosis in db/db mice. We conclude that aberrant DNA methylation of Tgfb1 due to ROS overproduction play a key to mesangial fibrosis during DN progression.
Characterizing directed functional pathways in the visual system by multivariate nonlinear coherence of fMRI data
Authors: Goelman Gadi , Dan Rotem , Keadan Tarek 
Published: October 2018

AbstractA multivariate measure of directed functional connectivity is used with resting-state fMRI data of 40 healthy subjects to identify directed pathways of signal progression in the human visual system. The method utilizes 4-nodes networks of mutual interacted BOLD signals to obtains their temporal hierarchy and functional connectivity. Patterns of signal progression were defined at frequency windows by appealing to a hierarchy based upon phase differences, and their significance was assessed by permutation testing. Assuming consistent phase relationship between neuronal and fMRI signals and unidirectional coupling, we were able to characterize directed pathways in the visual system. The ventral and dorsal systems were found to have different functional organizations. The dorsal system, particularly of the left hemisphere, had numerous feedforward pathways connecting the striate and extrastriate cortices with non-visual regions. The ventral system had fewer pathways primarily of two types: (1) feedback pathways initiated in the fusiform gyrus that were either confined to the striate and the extrastriate cortices or connected to the temporal cortex, (2) feedforward pathways initiated in V2, excluded the striate cortex, and connected to non-visual regions. The multivariate measure demonstrated higher specificity than bivariate (pairwise) measure. The analysis can be applied to other neuroimaging and electrophysiological data.
Probing heat generation during tensile plastic deformation of a bulk metallic glass at cryogenic temperature
Authors: Brennhaugen David D. E. , Georgarakis Konstantinos , Yokoyama Yoshihiko , Nakayama Koji S. , Arnberg Lars , Aune Ragnhild E. 
Published: October 2018

AbstractDespite significant research efforts, the deformation and failure mechanisms of metallic glasses remain not well understood. In the absence of periodic structure, these materials typically deform in highly localized, thin shear bands at ambient and low temperatures. This process usually leads to an abrupt fracture, hindering their wider use in structural applications. The dynamics and temperature effects on the formation and operation of those shear bands have been the focus of long-standing debate. Here, we use a new experimental approach based on localized boiling of liquid nitrogen by the heat generated in the shear bands to monitor the tensile plastic deformation of a bulk metallic glass submerged in a cryogenic bath. With the “nitrogen bubbles heat sensor”, we could capture the heat dissipation along the primary shear banding plane and follow the dynamics of the shear band operation. The observation of nitrogen boiling on the surface of the deforming metallic glass gives direct evidence of temperature increase in the shear bands, even at cryogenic temperatures. An acceleration in bubble nucleation towards the end of the apparent plastic deformation suggests a change from steady-state to runaway shear and premonitions the fracture, allowing us to resolve the sequence of deformation and failure events.
Fabrication of highly effective hybrid biofuel cell based on integral colloidal platinum and bilirubin oxidase on gold support
Authors: Hasan Md Qumrul , Kuis Robinson , Narayanan J. Shankara , Slaughter Gymama 
Published: October 2018

AbstractA hybrid biofuel cell (HBFC) is explored as a low-cost alternative to abiotic and enzymatic biofuel cells. Here the HBFC provides an enzymeless approach for the fabrication of the anodic electrode while employing an enzymatic approach for the fabrication of the cathodic electrode to develop energy harvesting platform to power bioelectronic devices. The anode employed 250 μm braided gold wire modified with colloidal platinum (Au-co-Pt) and bilirubin oxidase (BODx) modified gold coated Buckypaper (BP-Au-BODx) cathode. The functionalization of the gold coated multi-walled carbon nanotube (MWCNT) structures of the BP electrodes is achieved by 3-mercaptopropionic acid surface modification to possess negatively charged carboxylic groups and subsequently followed by EDC/Sulfo-NHS (1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-Hydroxysulfosuccinimide) crosslinking with BODx. The integration of the BODx and gold coated MWCNTs is evaluated for bioelectrocatalytic activity. The Au-co-Pt and BP-Au-BODx exhibited excellent electrocatalytic activity towards glucose oxidation with a linear dynamic range up to 20 mM glucose and molecular oxygen reduction, respectively. The HBFC demonstrated excellent performance with the largest open circuit voltages of 0.735 V and power density of 46.31 μW/cm2 in 3 mM glucose. In addition, the HBFC operating on 3 mM glucose exhibited excellent uninterrupted operational stability while continuously powering a small electronic device. These results provide great opportunities for implementing this simple but efficient HBFC to harvest the biochemical energy of target fuel(s) in diverse medical and environmental applications.
Conserved Pbp1/Ataxin-2 regulates retrotransposon activity and connects polyglutamine expansion-driven protein aggregation to lifespan-controlling rDNA repeats
Authors: Ostrowski Lauren A. , Hall Amanda C. , Szafranski Kirk J. , Oshidari Roxanne , Abraham Karan J. , Chan Janet N. Y. , Krustev Christian , Zhang Kevin , Wang Ashley , Liu Yupeng , Guo Ru , Mekhail Karim 
Published: October 2018

AbstractRibosomal DNA (rDNA) repeat instability and protein aggregation are thought to be two major and independent drivers of cellular aging. Pbp1, the yeast ortholog of human ATXN2, maintains rDNA repeat stability and lifespan via suppression of RNA–DNA hybrids. ATXN2 polyglutamine expansion drives neurodegeneration causing spinocerebellar ataxia type 2 and promoting amyotrophic lateral sclerosis. Here, molecular characterization of Pbp1 revealed that its knockout or subjection to disease-modeling polyQ expansion represses Ty1 (Transposons of Yeast) retrotransposons by respectively promoting Trf4-depedendent RNA turnover and Ty1 Gag protein aggregation. This aggregation, but not its impact on retrotransposition, compromises rDNA repeat stability and shortens lifespan by hyper-activating Trf4-dependent turnover of intergenic ncRNA within the repeats. We uncover a function for the conserved Pbp1/ATXN2 proteins in the promotion of retrotransposition, create and describe powerful yeast genetic models of ATXN2-linked neurodegenerative diseases, and connect the major aging mechanisms of rDNA instability and protein aggregation.
Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining
Authors: Seaborne R. A. , Strauss J. , Cocks M. , Shepherd S. , O’Brien T. D. , Someren K. A. van , Bell P. G. , Murgatroyd C. , Morton J. P. , Stewart C. E. , Mein C. A. , Sharples A. P. 
Published: October 2018

AbstractDNA methylation is an important epigenetic modification that can regulate gene expression following environmental encounters without changes to the genetic code. Using Infinium MethylationEPIC BeadChip Arrays (850,000 CpG sites) we analysed for the first time, DNA isolated from untrained human skeletal muscle biopsies (vastus lateralis) at baseline (rest) and immediately following an acute (single) bout of resistance exercise. In the same participants, we also analysed the methylome following a period of muscle growth (hypertrophy) evoked via chronic (repeated bouts-3 sessions/wk) resistance exercise (RE) (training) over 7-weeks, followed by complete exercise cessation for 7-weeks returning muscle back to baseline levels (detraining), and finally followed by a subsequent 7-week period of RE-induced hypertrophy (retraining). These valuable methylome data sets described in the present manuscript and deposited in an open-access repository can now be shared and re-used to enable the identification of epigenetically regulated genes/networks that are modified after acute anabolic stimuli and hypertrophy, and further investigate the phenomenon of epigenetic memory in skeletal muscle.
Datasets from a research project examining the role of politics in social psychological research
Authors: Viganola Domenico , Eitan Orly , Inbar Yoel , Dreber Anna , Johannesson Magnus , Pfeiffer Thomas , Thau Stefan , Uhlmann Eric Luis 
Published: October 2018

AbstractWe present four datasets from a project examining the role of politics in social psychological research. These include thousands of independent raters who coded scientific abstracts for political relevance and for whether conservatives or liberals were treated as targets of explanation and characterized in a negative light. Further included are predictions about the empirical results by scientists participating in a forecasting survey, and coded publication outcomes for unpublished research projects varying in political overtones. Future researchers can leverage this corpus to test further hypotheses regarding political values and scientific research, perceptions of political bias, publication histories, and forecasting accuracy.
Leitliniengerechte Indikationsstellung der Herzschrittmacher- und ICD-Therapie
Authors: Schlichting Andrea , Gosau Nils 
Published: October 2018

AbstractIn 2016, there were 77 293 pacemakers and 28 953 ICDs implanted in Germany. This makes pacemaker- and ICD-implantations part of the most frequently performed operations in Germany. This article addresses questions of correct indication and patient selection.
Optische Kohärenztomografie
Authors: Schneider Hartmut , Ziebolz Dirk , Krause Felix , Häfer Matthias , Rüger Claudia , Haak Rainer 
Published: October 2018

ZusammenfassungMit Telematik und Technologien wie „Digitale Abformung“, „CAD/CAM“ oder „3-D-Röntgen“ hat die Digitalisierung die zahnärztliche Praxis längst erreicht. Den Wunsch nach effizienterer Diagnostik verfolgt dabei besonders das 3-D-Röntgen. Ein nichtinvasiv abbildendes Verfahren, dem wir erhebliches diagnostisches Potenzial zubilligen, ist die optische Kohärenztomografie. In diesem Beitrag werden Beispiele aus der Zahnerhaltung dargestellt, die ein breites Anwendungsspektrum dieser neuartigen Technologie auch in der Zahnheilkunde erwarten lassen.
Strahlenrisiko auf Langzeitraumflügen
Authors: Hellweg Christine E. , Berger Thomas , Baumstark-Khan Christa 
Published: October 2018

ZusammenfassungDer alte Menschheitstraum, nach den Sternen zu greifen und den Fuß auf unbewohnte Planeten zu setzen, rückt für den heutigen Menschen in unmittelbare Nähe. Die technisch mögliche Reise zu Mond oder Mars kann für den „Homo spatialis“ mit Sonnenstürmen und Partikelbeschuss gepflastert sein und birgt medizinische Risiken: Vor allem die erhöhte Strahlendosis der solaren und galaktischen Komponenten der Weltraumstrahlung (Elektronen, Protonen und hochenergetische schwere Teilchen) kann zu einem bedrohlichen Gesundheitsrisiko werden. Je nach Missionsdesign besteht die Möglichkeit, durch unvorhersehbare Sonnenstürme akute Strahlenschäden zu erleiden und, bedingt durch die erhöhte biologische Wirksamkeit der galaktischen Strahlung, Langzeitschäden zu entwickeln. Abschätzungen zeigen, dass Astronauten während einer Marsreise mit einer Strahlenbelastung zu rechnen haben, die weit über dem amtlichen Grenzwert von jährlich 20 mSv für beruflich strahlenexponierte Personen in Europa liegt. Die Karrieredosis von Astronauten kann möglicherweise zu einem 3–4 % erhöhten zusätzlichen Krebsrisiko führen. Des Weiteren ist mit einem früheren und häufigeren Auftreten von Katarakten zu rechnen. Das Risiko für neurodegenerative Effekte ist zurzeit schwer einschätzbar. Gegenmaßnahmen umfassen Abschirmung, Warnsysteme für Sonnenstürme und unter Umständen auch diätetische und pharmakologische Mittel.
Medizinische Versorgung bei Langzeitmissionen in der Raumfahrt
Authors: Kerkhoff Steffen , Komorowski Matthieu , Schmitz Jan , Jansen Stefanie , Meyer Moritz F. , Warnecke Tobias , Hinkelbein Jochen 
Published: October 2018

ZusammenfassungIm Lichte zukünftiger Langzeitraumfahrtmissionen fernab der Erdumlaufbahn besitzt die Fähigkeit der Crew zur autonomen, medizinischen Versorgung einen besonderen Stellenwert. Hier ist insbesondere die Durchführung einer Anästhesie bei einer dringend notwendigen Operation von entscheidender Bedeutung, um unter Umständen die Mission weiter fortsetzen zu können. Bisher musste noch keine Allgemeinanästhesie in der Raumfahrt durchgeführt werden, sodass die praktische Erfahrung entsprechend limitiert ist. Es erscheint sinnvoll, in Umgebungen mit vergleichbaren medizinischen Versorgungssituationen nach Erfahrungswerten und Behandlungsstrategien zu suchen. Diese Umgebungen sollten über eine oder mehrere der Eigenschaften von Raumfahrtmissionen verfügen. Beispielsweise könnten dies Limitationen bei medizinischem Personal und Ausstattung oder die Unmöglichkeit einer zeitnahen Evakuierung zu einer höherwertigen Versorgungseinrichtung sein. Die vorliegende Übersichtsarbeit fasst die bisher zu diesem Thema publizierte Literatur zusammen und gibt einen Überblick über wichtige und bisher bekannte medizinische Maßnahmen in Schwerelosigkeit.
Partizipative Entscheidungsfindung – Patientenpartizipation im Kontext der medizinischen Entscheidungsfindung bei Ekzemen
Authors: Potempa Christoph 
Published: October 2018

Block J. Improving Value for Patients with Eczema. Value Health 2018; 21: 380–385
Die Autorin Block stellt in ihrem Artikel ein Zentrum zur partizipativen Entscheidungsfindung vor, dass die Patienten verstärkt in Behandlungsentscheidungen
integriert und ihnen eine aktive, gestaltende und dem Arzt gleichgestellte Rolle im Behandlungskontext einräumt. Die langfristigen Auswirkungen dieser
erhöhten Patientenpartizipation sind vielversprechend und mit schnelleren Heilungsraten sowie einer erhöhten Compliance und Lebensqualität der Patienten
verbunden.
Schwannoma plexiforme en eminencia tenar
Authors: Rodríguez Rodríguez Miriam , García Frasquet María Ángeles , Nieto Díaz de los Bernardos María Isabel 
Published: October 2018

ResumenEl schwannoma plexiforme es un tumor raro, que suele aparecer en tronco, cabeza y cuello. Su diagnóstico definitivo es anatomopatológico, siendo de especial relevancia su distinción con el neurofibroma plexiforme. No se ha descrito potencial de malignización y el tratamiento de elección es la extirpación quirúrgica. Presentamos el caso de un varón de 34 con una tumoración dolorosa en eminencia tenar derecha. Tras realizar RNM que sugiere hemangioma cavernoso, se interviene quirúrgicamente realizándose escisión de la tumoración, cuyo estudio histológico diagnostica de schwannoma plexiforme. A los 12 meses de la cirugía, el paciente se encuentra asíntomático, sin mostrar signos de recidiva o enfermedades asociadas.
Advanced Glycation End Products:Receptors for Advanced Glycation End Products Axis in Coronary Stent Restenosis: A Prospective Study
Authors: Pearce Colin , Islam Naorin , Bryce Robyn , McNair Erick 
Published: October 2018

AbstractThis study was aimed to correlate the pre- and 6-month postpercutaneous coronary intervention (PCI) serum concentrations of advanced glycation end products (AGE), soluble receptors for advanced glycation end products (sRAGE), AGE/sRAGE ratio, and serum malondialdehyde (MDA) levels with in-stent restenosis (ISR) among patients receiving either a drug-eluting stent (DES) or a bare-metal stent (BMS).In-stent restenosis remains as an adverse outcome following PCI. Sixty consecutive nondiabetic, Caucasian male patients, diagnosed with a non-ST-elevation myocardial infarction who received either a DES or BMS via PCI, were enrolled. Baseline levels of serum AGE, sRAGE, AGE/sRAGE ratios, MDA, and angiographic parameters were determined at stenting and at 6 months. Patients with and without ISR at 6 months were compared on both baseline and 6-month biomarker levels and within stent types.The pre-PCI serum AGE levels and AGE/sRAGE ratios were higher in ISR patients compared with non-ISR patients, while the pre-PCI and post-PCI serum sRAGE levels were lower in ISR patients compared with non-ISR patients. The pre and post-PCI levels of MDA were also higher in ISR patients. Comparing stent types, relative levels of MDA between those with and without ISR at the respective time points were similar, although changes between time points appeared type specific.Post-PCI ISR correlates with low serum values of sRAGE and high serum values of AGE, MDA, and AGE/sRAGE ratio which are present at stenting. The associations of baseline AGE, sRAGE, AGE/sRAGE, and MDA levels with ISR appear consistent between stent types.
Probability of Success in the Ophthalmology Residency Match: Three-Year Outcomes Analysis of San Francisco Matching Program Data
Authors: Siatkowski R. , Mian Shahzad , Cullican Susan , Green Laura , Sun Grace , Waxman Evan , Wayman Laura , Stoner Julie , Chen Xi , Feldon Steven ,   for the Association of University Professors of Ophthalmology
Published: October 2018

Objective To develop a probability model of matching into a US ophthalmology residency program using San Francisco Matching Program (SF Match) data.
Design Retrospective data analysis of de-identified application and matching data.
Participants Registrants for the 2013, 2014, and 2015 ophthalmology residency matches conducted by the SF Match.
Methods Descriptive statistics of candidates, comparison of continuous and categorical variables between matched and nonmatched candidates, and linear regression modeling were performed. A recursive partitioning method was used to create a probability of matching algorithm.
Main Outcome Measures Probability of successfully matching based on quantifiable candidate characteristics.
Results Over the 3-year period, 1,959 individuals submitted an average of 64 applications and received a mean of nine interview invitations. The overall match rate was 71%, with 78% matching at one of their top five choices. Successful matches were more likely to occur in US medical school graduates (78% vs 20%, p < 0.001) and applicants on their first attempt (76% vs 29%, p < 0.001). The association between matching and number of programs applied became negative with > 48 applications. Probability of matching was “high” (> 80%) among US graduates with a step 1 United States Medical Licensing Examination (USMLE) score >243 (regardless of number of programs applied to), a step 1 USMLE score of 231 to 243 who applied to at least 30 programs, and first-time applicants with a step 1 score >232. No international medical graduates or repeat applicants had a “high” probability of matching.
Conclusions Although advice must be individualized for each candidate, applicants for ophthalmology residency who fall into a “high” probability of matching group are likely to be successful with applications to 45 or fewer programs. Applying to 80 or more programs should be considered for international medical graduates and/or applicants who are previously unmatched. Modification of the match application data form may allow more detailed analysis of variables such as Alpha Omega Alpha or Gold Humanism Honor Society membership, research activity, and composite evaluation on a standardized letter of recommendation.