bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gorboduc Now! The First English Tragedy in Modern Print and Performance
Authors: Winston Jessica 
Published: July 2019

Abstract
This article surveys the modern reception of the first English tragedy Gorboduc, first reviewing references to Gorboduc in popular print and literature and then in performance. For a long time in the popular press, the play formed part of a framework of cultural knowledge that educated people were assumed to have or desire. Productions of Gorboduc grew out of that context. Implicitly hearkening back to the Renaissance ethos of ‘teach and delight’, they offered audiences an appealing way to reinforce their awareness of English drama. Beyond this dominant trend in the play’s reception, Gorboduc has circulated in another way – as a work that not only represents the past but which also speaks to contemporary times. While the play once represented general information that educated people ought to know, clearly this is no longer the case. Considering this fact, this article suggests that it is possible to rehabilitate the play by building on presentist understandings of the play already present in its modern reception in popular print and performance – that is, to emphasise why Gorboduc continues to be relevant by more explicitly framing it and other Tudor plays in relation to topics that dominate the sixteenth century and matter now, such as tyranny, counsel, and territorial disunion.
Roman Exempla in the Early Tudor Period
Authors: Kern Darcy 
Published: July 2019

Abstract
Roman exempla, or moralizing anecdotes, appear frequently in the English literature of the early Tudor period. Textual, authorial, and historical exempla offered a language people could use to counsel the king and their fellow Englishmen and women. As a teacher of individual virtue, Roman exempla remained fairly stable throughout the period, though translators themselves became more conscious of their role as counsellors and more visible in their texts through their prefatory material. As a political guide for England, Roman exempla became more problematic over the course of the early Tudor period. Authors increasingly discouraged kings and nobles from heeding popular counsel and encouraged them to rely more on printed Roman exempla and the translators who wrote them.
‘The earth … shall eat us all’: Exemplary History, Post-Humanism, and the Legend of King Ferrex in Elizabethan Poetry and Drama
Authors: Archer Harriet 
Published: July 2019

Abstract
The legend of King Ferrex was employed by Thomas Norton and Thomas Sackville in their succession play, Gorboduc (first performed 1561), and by John Higgins in his Mirror for Magistrates (1574; 1587), to reflect on contemporary politics and offer topical warnings to Elizabeth I and her subjects based on legendary British history. However, as well as including a section specifically focused on environmental exploitation, Higgins imbues the earth with a destructive animism in his poem which stands apart as an anomaly in his collection of verse complaints and amongst wider treatments of the story. Higgins’s emphasis on the arbitrary amoral and areligious destruction of all by the agency of the earth and other non-human actors challenges the Mirror’s educative model, and renders the Gorboduc legend inert. Looking at various versions of the narrative in Gorboduc, Higgins’s Mirror, and William Warner’s Albion’s England (1586), and analogous uses of environmental discourse in other contemporary poetic and dramatic texts by Shakespeare, Spenser, and Marlowe, this article considers the role of the nonhuman, and specifically the earth itself, in early modern imaginative historiography and political commentary. In particular, it suggests that there are fruitful connections to be made between modern posthumanist theoretical approaches, and the post-humanism of Higgins’s approach to exemplary history, whereby his admonitory text appears to abandon its premise of human primacy and perfectability in response to the perceived failure of Elizabethan advice literature to effect political change.
The contemporary force balance in a wide accretionary wedge: numerical models of the southcentral Hikurangi margin of New Zealand
Authors: Ellis Susan , Ghisetti Francesca , Barnes Philip M , Boulton Carolyn , Fagereng Åke , Buiter Susanne 
Published: July 2019

SUMMARYThe southcentral Hikurangi subduction margin (North Island, New Zealand) has a wide, low-taper accretionary wedge that is frontally accreting a >3-km-thick layer of sediments, with deformation currently focused near the toe of the wedge. We use a geological model based on a depth-converted seismic section, together with physically realistic parameters for fluid pressure, and sediment and décollement friction based on laboratory experiments, to investigate the present-day force balance in the wedge. Numerical models are used to establish the range of physical parameters compatible with the present-day wedge geometry and mechanics. Our analysis shows that the accretionary wedge stability and taper angle require either high to moderate fluid pressure on the plate interface, and/or weak frictional strength along the décollement. The décollement beneath the outer wedge requires a relatively weaker effective strength than beneath the inner (consolidated) wedge. Increasing density and cohesion with depth make it easier to attain a stable taper within the inner wedge, while anything that weakens the wedge—such as high fluid pressures and weak faults—make it harder. Our results allow a near-hydrostatic wedge fluid pressure, sublithostatic fluid overpressure at the subduction interface, and friction coefficients compatible with measurements from laboratory experiments on weak clay minerals.
Identification and characterization of collagen-like glycosylation and hydroxylation of CCN1
Authors: Ishizawa Yudai , Niwa Yuki , Suzuki Takehiro , Kawahara Ryota , Dohmae Naoshi , Simizu Siro 
Published: July 2019

AbstractCCN1 is a secreted protein and belongs to the CCN family of matricellular proteins. CCN1 binds to various cell surface receptors; thus, CCN1 has important functions in cell proliferation, migration and angiogenesis through a variety of signaling pathways. We have reported that CCN1 is O-fucosylated and that this O-fucosylation regulates the secretion of CCN1 into the extracellular region. In this study, we detected collagen-like glycosylation and hydroxylation at Lys203 of recombinant CCN1 by mass spectrometry. We then examined the role of collagen-like glycosylation in the functions of CCN1. As a result, we found that a deficiency in collagen-like glycosylation decreased the secretion of CCN1 using wild-type CCN1- and collagen-like glycosylation-defective mutant CCN1-overexpressing cell lines. Further, knockout of lysyl hydroxylase3, a multifunctional protein with hydroxylase and glucosyltransferase activities, impaired the secretion and glycosylation level of recombinant CCN1. Previous studies reported that collagen glycosylation of Lys residues mediated by lysyl hydroxylase3 is glucosyl-galactosyl-hydroxylation, presuming that this collagen-like glycosylation detected at Lys203 of recombinant CCN1 in this study might be glucosyl-galactosyl-hydroxylation. Taken together, our results demonstrate the novel function of the collagen-like glycosylation of CCN1 and suggest that lysyl hydroxylase3-mediated glycosylation is important for CCN1 secretion.
Impact of sialyltransferase ST6GAL1 overexpression on different colon cancer cell types
Authors: Venturi Giulia , Gomes Ferreira Inês , Pucci Michela , Ferracin Manuela , Malagolini Nadia , Chiricolo Mariella , Dall’Olio Fabio 
Published: July 2019

AbstractCancer-associated glycan structures can be both tumor markers and engines of disease progression. The structure Siaα2,6Galβ1,4GlcNAc (Sia6LacNAc), synthesized by sialyltransferase ST6GAL1, is a cancer-associated glycan. Although ST6GAL1/Sia6LacNAc are often overexpressed in colorectal cancer (CRC), their biological and clinical significance remains unclear. To get insights into the clinical relevance of ST6GAL1 expression in CRC, we interrogated The Cancer Genome Atlas with mRNA expression data of hundreds of clinically characterized CRC and normal samples. We found an association of low ST6GAL1 expression with microsatellite instability (MSI), BRAF mutations and mucinous phenotype but not with stage, response to therapy and survival. To investigate the impact of ST6GAL1 expression in experimental systems, we analyzed the transcriptome and the phenotype of the CRC cell lines SW948 and SW48 after retroviral transduction with ST6GAL1 cDNA. The two cell lines display the two main pathways of CRC transformation: chromosomal instability and MSI, respectively. Constitutive ST6GAL1 expression induced much deeper transcriptomic changes in SW948 than in SW48 and affected different genes in the two cell lines. ST6GAL1 expression affected differentially the tyrosine phosphorylation induced by hepatocyte growth factor, the ability to grow in soft agar, to heal a scratch wound and to invade Matrigel in the two cell lines. These results indicate that the altered expression of a cancer-associated glycosyltransferase impacts the gene expression profile, as well as the phenotype, although in a cancer subtype-specific manner.
Left ventricular outflow tract obstruction by transatrial left ventricular cannulation
Authors: Nakahara Yoshinori , Kanemura Takeyuki , Shioya Masato , Yamana Koji 
Published: July 2019

Abstract
Transatrial cannulation of the left ventricle was introduced as a safe and easy cannulation method for antegrade arterial return in type A aortic dissection. However, because of the paucity of clinical reports, little is known about the complications or shortcomings of this technique. Herein, we report a case of pulmonary haemorrhage resulting from left ventricular outflow obstruction, necessitating the exchange of the arterial cannulation site. Monitoring the jet of the arterial cannula with transoesophageal echocardiography and pulmonary artery pressure is mandatory for early detection of complications.
Efficient optimized design of solar power tower plants based on successive response surface methodology
Authors: Luo Yan , Hu Yue , Lu Tao 
Published: July 2019

AbstractRecently the optimal design of the solar power tower (SPT) plants have attracted increasing attention. In this paper, an improved algorithm combing the successive response surface methodology (SRSM) and simulated annealing (SA) global algorithm was proposed to achieve the efficient optimization design of the molten salt SPT plant with 2650 heliostats in Sevilla, Spain. Based on the traditional response surface methodology (RSM) and the adaptive domain reduction method, the SRSM was established to surrogate the complex thermo-economic model of the SPT plant to the updated approximation function, which was a high-order polynomial form to define the relationship between the objective parameter of the levelized cost of energy (LCOE) and 12 design variables related to the 4 subsystems of the SPT plant. After that, the SPT plant optimization design was performed by the SA global algorithm on the basis of SRSM. According to a comparison between the results obtained by the proposed method and the actual model-based global algorithm, the high accuracy and low computation time of the proposed strategy was proved.
Description of a Bizarre New Genus and Species of Ambush Bugs from the Dominican Republic (Heteroptera: Reduviidae: Phymatinae)
Authors: Masonick Paul K 
Published: July 2019

AbstractEnigmatic and rarely collected, ambush bugs of the tribe Macrocephalini (Heteroptera: Reduviidae: Phymatinae) encompass a diverse group of predatory bugs armed with subchelate raptorial forelegs, a greatly enlarged scutellum, and elongate head. Macrocephalini is the most specious of the four tribes of ambush bugs, consisting of 20 genera and 154 species. They are represented in the Caribbean by several remarkable taxa that bear foretarsi, a trait unassociated with macrocephalines found elsewhere in the world. I here describe a new genus and species of Macrocephalini, Capricephala chiaroscuro gen. et sp. nov., native to the island of Hispaniola and one that bears striking differences to other phymatines known from that region.
Opinion-Formation and Issue-Framing Effects of Russian News in Kyrgyzstan
Authors: Chapman Hannah S , Gerber Theodore P 
Published: July 2019

Abstract
Powerful countries use foreign media broadcasts to enhance their soft power, yet there is scant empirical evidence as to whether such efforts actually sway public opinion abroad. Moreover, researchers have not specified conditions that may shape variations in the influence of foreign broadcasts and internet. We propose a theory that predicts, respectively, opinion-formation and issue-framing effects of foreign broadcasts as functions of the pervasiveness and familiarity of the issues they cover. We test our hypotheses by examining the potential effects of exposure to Russia-sourced broadcasts on views of Russia and other foreign policy issues in Kyrgyzstan, a most likely case of foreign media effects. Using an original, nationally representative survey conducted in Kyrgyzstan in 2015, we find that the influence of Russian media on Kyrgyzstani opinions varies according to the pervasiveness and familiarity of the issues at stake and is more limited than traditionally believed. The modest and conditional effects of foreign media in this particularly favorable environment cast doubt on the assumption that media are a soft-power tool “par excellence” and call for further research on how media can be used effectively for public diplomacy.
Use of darunavir in HIV-1-infected individuals in routine clinical practice from 2012 to 2016 in France
Authors: Potard Valérie , Canestri Ana , Gallien Sebastien , Costagliola Dominique ,   French Hospital Database on HIV, Abgrall S , Bernard L , Billaud E , Boué F , Boyer L , Cabié A , Caby F , Canestri A , Costagliola D , Cotte L , De Truchis P , Duval X , Duvivier C , Enel P , Fischer H , Gasnault J , Gaud C , Grabar S , Katlama C , Khuong M A , Launay O , Marchand L , Mary-Krause M , Matheron S , Melica-Grégoire G , Melliez H , Meynard J L , Nacher M , Pavie J , Piroth L , Poizot-Martin I , Pradier C , Reynes J , Rouveix E , Simon A , Slama L , Tattevin P , Tissot-Dupont H , Astier G , Kurth T , Jacquemet N , Costagliola D , Abgrall S , Grabar S , Guiguet M , Leclercq S , Lièvre L , Mary-Krause M , Roul H , Selinger-Leneman H , Potard V 
Published: July 2019

AbstractObjectivesWe assessed virological outcomes of darunavir use in France from 2012 to 2016, in three groups of people living with HIV (PLHIV): (i) antiretroviral (ARV)-naive PLHIV; (ii) ARV-experienced PLHIV switching to darunavir while failing therapy; and (iii) ARV-experienced PLHIV switching to darunavir while virologically controlled.MethodsVirological success (VS) was defined as a plasma HIV-1 viral load (VL) <50 copies/mL and virological failure (VF) as two consecutive VL >50 copies/mL or one VL >50 copies/mL followed by a treatment switch prior to the next VL measurement. The cumulative incidence of VS was assessed considering darunavir discontinuation, loss to follow-up and death as competing risks, while estimates of cumulative incidence of VF accounted for loss to follow-up and death.ResultsAmong the 3235 ARV-naive PLHIV initiating darunavir, the 4 year cumulative incidence of VS was 80.9% and was associated with lower VL and higher CD4 cell counts. Among the 3485 ARV-experienced PLHIV switching to darunavir while failing therapy, the 4 year cumulative incidence of VS was 82.2% and was associated with lower VL. Among the 3005 ARV-experienced PLHIV switching to darunavir while virologically controlled, the 4 year cumulative incidence of VF was 12.6%. The risk of VF was higher with darunavir monotherapy [subdistribution hazard ratio (sHR)=1.67, 95% CI 1.15–2.42] while no difference was observed with dual therapy (sHR = 1.00, 95% CI 0.71–1.42) relative to triple therapy or more.ConclusionsDarunavir-containing regimens yielded similarly high rates of viral suppression in PLHIV whether they were ARV naive or ARV experienced switching to darunavir while failing therapy, or of maintaining VS in ARV-experienced PLHIV switching to darunavir while virologically controlled.
The impact of dietary supplementation of arginine during gestation in a commercial swine herd: I. Gilt reproductive performance
Authors: Hines Elizabeth A , Romoser Matthew R , Kiefer Zoë E , Keating Aileen F , Baumgard Lance H , Niemi Jarad , Gabler Nicholas K , Patience John F , Haberl Benjamin , Williams Noel H , Kerr Brian J , Touchette Kevin J , Ross Jason W 
Published: July 2019

Abstract
Supplemental arginine (Arg) during gestation purportedly benefits fetal development. However, the benefits of a gestational Arg dietary strategy in commercial production are unclear. Therefore, the objectives of this study examined Arg supplementation during different gestational stages and the effects on gilt reproductive performance. Pubertal gilts (n = 548) were allocated into 4 treatment groups: Control (n = 143; 0% supplemental Arg) or 1 of 3 supplemental Arg (1% as fed) treatments: from 15 to 45 d of gestation (n = 138; Early-Arg); from 15 d of gestation until farrowing (n = 139; Full-Arg); or from 85 d of gestation until farrowing (n = 128; Late-Arg). At farrowing, the number of total born (TB), born alive (BA), stillborn piglets (SB), mummified fetuses (MM), and individual piglet birth weights (BiWt) were recorded. The wean-to-estrus interval (WEI) and subsequent sow reproductive performance (to third parity) were also monitored. No significant effect of supplemental Arg during any part of P0 gestation was observed for TB, BA, SB, or MM (P ≥ 0.29). Offspring BiWt and variation among individual piglet birth weights did not differ (P = 0.42 and 0.89, respectively) among treatment groups. Following weaning, the WEI was similar among treatments (average of 8.0 ± 0.8 d; P = 0.88). Litter performance over 3 parities revealed a decrease (P = 0.02) in BA for Early-Arg fed gilts compared with all other treatments, whereas TB and WEI were similar among treatments over 3 parities (P &gt; 0.05). There was an increased proportion of sows with average size litters (12 to 16 TB) from the Full-Arg treatment sows (76.8% ± 3.7%) when compared with Control (58.7% ± 4.2%; P = 0.01); however, the proportion of sows with high (&gt;16 TB) and low (&lt;12 TB) litters was not different among treatments (P = 0.20). These results suggest that gestational Arg supplementation had a minimal impact on reproductive performance in first parity sows. These data underscore the complexity of AA supplementation and the need for continued research into understanding how and when utilizing a gestational dietary Arg strategy can optimize fetal development and sow performance.
Successful reversal of ovarian hyperstimulation syndrome in a mouse model by rapamycin, an mTOR pathway inhibitor
Authors: Liu Wenwen , Zhang Chi , Wang Lu , Huang Xuan , Zhang Jing , He Yuanlin , Chen Li , Li Jing 
Published: July 2019

Abstract
Ovarian hyperstimulation syndrome (OHSS) is a potentially life-threatening, iatrogenic complication of ovarian stimulation in assisted reproduction technology. This complex syndrome is characterised by enlarged ovaries with multiple corpora luteum, elevated sex steroid hormones in serum and increased capillary permeability. Until now, the pathogenesis of OHSS remains obscure, and no absolute strategy can fully prevent OHSS without any side effect on ovulation and clinical pregnancy. Using cultured human or mouse granulosa cells, our study revealed the time-dependent activation of the mTOR signaling pathway after human chorionic gonadotropin (hCG) treatment. The involvement of the mTOR signaling pathway was also observed in the development of OHSS in a mouse model. Selectively inhibiting mTOR signals by only two injections of rapamycin (2 mg/kg body weight), before or just after hCG treatment, significantly reduced vascular leakage and the severity of OHSS symptoms. Although ovarian angiogenesis was significantly inhibited, rapamycin could not decrease the elevated levels of vascular endothelial growth factor, IL-6 and IL-11 in OHSS ovaries. Further study showed the functional roles of the mTOR signaling pathway in the hyperstimulation-induced ovarian extracellular matrix remodeling as the expression of α2M, a broad proteolytic inhibitor in both ovary and serum, was dramatically decreased after rapamycin treatment. Since a single injection of rapamycin during superovulation had no side effects on ovulation and early embryonic development, we propose rapamycin may be a good candidate to lower and prevent the risk of OHSS in the future.
Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage
Authors: Giovannini Sara , Weller Marie-Christine , Repmann Simone , Moch Holger , Jiricny Josef 
Published: July 2019

AbstractPoly(ADP-ribose) polymerases (PARPs) facilitate the repair of DNA single-strand breaks (SSBs). When PARPs are inhibited, unrepaired SSBs colliding with replication forks give rise to cytotoxic double-strand breaks. These are normally rescued by homologous recombination (HR), but, in cells with suboptimal HR, PARP inhibition leads to genomic instability and cell death, a phenomenon currently exploited in the therapy of ovarian cancers in BRCA1/2 mutation carriers. In spite of their promise, resistance to PARP inhibitors (PARPis) has already emerged. In order to identify the possible underlying causes of the resistance, we set out to identify the endogenous source of DNA damage that activates PARPs. We argued that if the toxicity of PARPis is indeed caused by unrepaired SSBs, these breaks must arise spontaneously, because PARPis are used as single agents. We now show that a significant contributor to PARPi toxicity is oxygen metabolism. While BRCA1-depleted or -mutated cells were hypersensitive to the clinically approved PARPi olaparib, its toxicity was significantly attenuated by depletion of OGG1 or MYH DNA glycosylases, as well as by treatment with reactive oxygen species scavengers, growth under hypoxic conditions or chemical OGG1 inhibition. Thus, clinical resistance to PARPi therapy may emerge simply through reduced efficiency of oxidative damage repair.