bluuebunny/crossref_metadata_2025_split huggingface dataset:
Possible Considerations for the Management of Turcot’s Syndrome?
Authors: Nikova Alexandrina , Ganchev Dimitar , Birbilis Theodossios 
Published: July 2018

Background:Turcot’s syndrome (TS) is a rare disease with known incidence of about 1-2 cases per year. It is, however, linked to high mortality due to the brain cancer. And because of this, we propose recommendations, aimed at preventing the mortality of the patients and to minimize the risk of undiagnosed Turcot’s syndrome.Methods:The authors collected the worldwide published data on TS, from the year of its definition till 2018, all of which was published on the search engines, such as Medline, Medknow, Cohraine and Wiley.Results:We included 97 patients, 57 from which are females and 40 males with median age of 22 years. The most common type of cancer is medulloblastoma, followed by glioblastoma and astrocytoma. We further divided the patients into two categories based on the first symptom of the disease and we made an algorithm of approaching these patients.Conclusion:TS is a disease that affects mostly members of families with multiple genetic mutations and types of cancers. And because of the unknown mechanisms of inheritance, it is useful to establish guidelines for the approach of those patients, in order to minimize the high mortality rate.
Effect of Meat Sources on Nutritional Composition and Heavy Metal Profile of Suya (A West African Grilled Meat)
Authors: Adeyeye Samuel A.O. 
Published: July 2018

Objective:This study investigated the effect of meat sources on amino acids, vitamin, minerals and heavy metal profile in suya.Methods:Meat of cow (beef), goat (veal), sheep (mutton) and chicken samples were obtained from Ibadan, Nigeria. Forty (40) samples of each suya meat of cow (beef), goat (veal), sheep (mutton) and chicken were prepared. The amino acid analysis, vitamin, mineral and heavy metal profile of the suya samples were determined using standard methods.Results:The results showed that there were significant differences (p ≤ 0.05) in the amino acid, vitamin and mineral of suya samples. The amino acid concentration in g/100g crude protein of suya meats of cow, goat (veal), sheep (mutton) and chicken samples for lysine, arginine and leucine were 7.72±0.03, 7.63±0.04, 7.47±0.04 and 7.83±0.03 respectively for lysine; 6.39±0.02, 6.27±0.02, 6.54±0.01 and 6.48±0.02 respectively for arginine and 7.32±0.01, 7.41±0.01, 7.68±0.01 and 7.54±0.01 respectively for leucine. The non-essential amino acids, glutamic acid, aspartic acid and glycine were the most abundant amino acids in all the suya from beef, goat, sheep and chickens meats. The amino acid composition of suya samples from different meat sources was compared with that of a standard protein recommended by the World Health Organization (WHO). The study showed that the suya samples contained high amounts of vitamin B-complex and minerals, and low amounts of heavy metals.Conclusion:In conclusion, the suya samples from beef, goat, sheep and chickens meats are good sources of lysine, which is severely restricted in cereals, the most important staple food.
Evaluation of Cytotoxic Effect, Anti-Cholinesterase, Hemolytic and Antibacterial activities of the Species Scabiosa stellata L.
Authors: Mouffouk Chaima , Hambaba Leila , Haba Hamada , Mouffouk Soumia , Bensouici Chawki 
Published: July 2018

Objective:
In this study, cytotoxic effect, anticholinesterase, hemolytic and antibacterial
activities of crude extracts (petroleum ether, ethyl acetate and n-butanol) obtained from the plant
Scabiosa stellata L. were evaluated.

Methods:
The cytotoxicity of extracts was tested by Brine shrimp lethality method; the acetylcholinesterase
inhibitory activity was performed using Ellman's colorimetric method and the hemolytic
activity was assessed by spectrophotometric method towards human erythrocytes. Furthermore, the
antibacterial activity was estimated by agar disk diffusion assay against ten bacterial strains.

Results:
The phytochemical screening of the extracts revealed the presence of several types of secondary
metabolites. A significant cytotoxic effect was observed for the n-butanolic extract with 57.2 ± 0.2
% of mortality at 80 μg/mL, the ethyl acetate extract had a moderate anticholinesterase activity at 200
μg/mL. The hemolytic assay exhibited that n-butanolic and ethyl acetate extracts induce hemolysis in
dose-dependent manner with values of EC50 at 37.3 ± 0.5 and 106.6 ± 0.3 μg/mL, respectively. All the
crude extracts showed antibacterial activity against most tested strains, with zones of inhibition ranging
from 9 to 20 mm.

Conclusion:
The results indicate that the extracts obtained from S. stellata can be an important source
of therapeutic agents against pathological damage due to free radicals inducing neurodegenerative and
infectious diseases, while n-butanolic extract could be used as a good source of alternative natural antiproliferative
compounds.
A Comparative Phytochemical and Biological Study between Different Solvent Extracts of Leaves and Stems Extracts of Erica arborea L. and Viburnum tinus L. Plants Growing in Tunisia
Authors: Elaloui Meriem , Ennajah Amel , Ghazghazi Hanene , Issami Wiem , Mekni Abir , Ahmed Hela B. , Laamouri Abdelwahed 
Published: July 2018

Background:Many Tunisian medicinal plants are widespread and are used in modern ethnomedecin due to their interesting biological activities. Considering natural products of plant origin, this study was conceived to evaluate the allelopathic effect of leaf and stem extracts of Erica arborea and Viburnum tinus on the seed germination and seedling development of Avena sativa. We identified the secondary metabolites that were responsible.Methods:Total phenols, flavonoids, tannins contents and antioxidant activity were evaluated using the Folin ciocalteux, Aluminum trichloride, vanillin and scavenging activity on 2, 2-diphenyl- 1picrylhydrazyl (DPPH) radicals methods, respectively. Leaf powders (5, 20, 40, 60 and 100 g) were macerated each with 1000 ml of distilled water for 24 h. The extracts were filtered through Whatman N°1 filter paper, pooled and concentrated under vacuum. Allelopathic bioassays were conducted using the obtained supernatant.Results:The obtained results indicated that acetonic extracts of the Viburnum leaves had the highest levels of total phenols (36.82 mg / g), flavonoïds (11.99 mg / g) and tannins (7.93 mg / g) and recorded a high antioxidant activity (0.054 mg / ml). Both test species showed that all organs had significant inhibitory effect on the development of Avena sativa. The leaves of Viburnum are best from the point of view inhibition of root length (-85.45%) and height of the aerial part (-78.95%).Conclusion:The inhibitory effects of these extracts were manifested much more on the development of seedlings. Extracts from Viburnum tinus leaves were the best inhibitors and could be regarded as promising candidates for natural plant source of antioxidant and herbicide agents.
Simultaneous Monitoring of Febuxostat and Uric Acid in Human Serum Samples Using the Direct Square-Wave Voltammetric Method
Authors: Nigović Biljana , Vlak Jakov 
Published: July 2018

Background:
High uric acid serum level, hyperuricemia, is now associated with many diseases
such as gout, chronic kidney disease, hypertension, coronary artery disease and diabetes. Febuxostat
is a novel selective xanthine oxidase inhibitor approved for the treatment of hyperuricemia.

Objective:
The aim of this study was to develop a first analytical method for the simultaneous determination
of febuxostat and uric acid.

Methods:
An unmodified boron-doped diamond electrode provided concurrent quantitation of drug at
low levels and uric acid, which has clinical significance in the diagnosis and therapy of hyperuricemia,
at relatively high concentrations. The direct square-wave voltammetric method was applied to the
analysis of both analytes in human serum samples.

Results:
Under the optimized conditions, the linear response of peak current on febuxostat concentration
was achieved in the range from 7.5 × 10-7 to 3 × 10-5 M, while uric acid showed two linear ranges
of 5 × 10-6 - 5 × 10-5 M and 5 × 10-5 - 2 × 10-4 M. The method was successfully utilised for quantification
of both analytes in human serum samples. Good recoveries were obtained without interference
from common inorganic cations and anions as well as glucose, dopamine, ascorbic and folic acids at
concentrations expected in physiological conditions.

Conclusion:
The great benefits of developed method are fast analysis (only 7.5 s for run), low cost
and simplicity of performance.
Energy Efficient Techniques in Wireless Sensor Networks
Authors: Chugh Amit , Panda Supriya 
Published: July 2018

Background:Wireless Sensor Network (WSN) is a collection of tiny electromechanical nodes termed as sensors. Sensors are equipped with sensing unit, which is designed for application specific. When deployed either by planned or unplanned after deployment, sensor’s energy starts depleting due to various roles like sensing, communication and aggregation.Method:WSN is challenged with limited battery power. The aim is to enhance energy efficiency that leads to a prolonged lifetime of networks.Results:We have reviewed the patents related to energy efficiency in wireless sensor networks. This Paper presents the study of various energy efficient techniques, which can enhance the lifetime of sensor networks; it covers basics of WSN, their design, Classification, Communication in WSN and a survey of different techniques for effective utilization of sensor’s energy.Conclusion:Paper has emphasized on energy efficient clustering technique along with feature wise summary of existing clustering protocols.
A Motion-Activated Video Game for Prevention of Substance Use Disorder Relapse in Youth: Pilot Randomized Controlled Trial (Preprint)
Authors: Abroms Lorien C , Fishman Marc , Vo Hoa , Chiang Shawn C , Somerville Victoria , Rakhmanov Lawrence , Ruggiero Michael , Greenberg Daniel 
Published: July 2018

BACKGROUND

Body motion-activated video games are a promising strategy for promoting engagement in and adherence to addiction treatment among youth.

OBJECTIVE

This pilot randomized trial (N=80) investigated the feasibility of a body motion–activated video game prototype, Recovery Warrior 2.0, targeting relapse prevention in the context of a community inpatient care program for youth.

METHODS

Participants aged 15-25 years were recruited from an inpatient drug treatment program and randomized to receive treatment as usual (control) or game play with treatment as usual (intervention). Assessments were conducted at baseline, prior to discharge, and at 4 and 8 weeks postdischarge.

RESULTS

The provision of the game play intervention was found to be feasible in the inpatient setting. On an average, participants in the intervention group played for 36.6 minutes and on 3.6 different days. Participants in the intervention group mostly agreed that they would use the refusal skills taught by the game. Participants in the intervention group reported attending more outpatient counseling sessions than those in the control group (10.8 versus 4.8), but the difference was not significant (P=.32). The game had no effect on drug use at 4 or 8 weeks postdischarge, with the exception of a benefit reported at the 4-week follow-up among participants receiving treatment for marijuana addiction (P=.04).

CONCLUSIONS

Preliminary evidence indicates that a motion-activated video game for addiction recovery appears to be feasible and acceptable for youth within the context of inpatient treatment, but not outpatient treatment. With further development, such games hold promise as a tool for the treatment of youth substance use disorder.

CLINICALTRIAL

ClinicalTrials.gov NCT03957798; https://clinicaltrials.gov/show/NCT03957798 (Archived by WebCite at http://www.webcitation.org/78XU6ENB4)
ANALISIS PENGARUH LEVERAGE, UKURAN PERUSAHAAN DAN PROFITABILITAS TERHADAP KETEPATAN WAKTU PELAPORAN KEUANGAN PADA PERUSAHAAN PERBANKAN
Authors: E Janrosl Viola Syukrina 
Published: July 2018

<p><em>This study aims to provide information on what factors make the company not timely in reporting financial statements that will be relevant information for investors in business and economic decision-making. The population in this study is the financial statements of banking companies listed on the Indonesia Stock Exchange. The sample in this study is the financial statements of banking companies listed on the Indonesia Stock Exchange from 2014-2016. This study uses descriptive statistics, t test and F test. The results of this study firm size partially significant effect on the timeliness of financial reporting while profitability and leverage have no significant effect on the timeliness of financial reporting. F test results obtained significant value 0.025 &lt;0.05 which shows simultaneously leverage, firm size, and profitability significantly influence the timeliness of financial reporting.</em></p><p> </p><p>Penelitian ini bertujuan untuk memberikan informasi mengenai faktor-faktor apa yang membuat perusahaan tidak tepat waktu dalam melaporkan laporan keuangan yang akan menjadi informasi yang relevan bagi investor dalam pengambilan keputusan bisnis dan ekonomi. Populasi dalam penelitian ini adalah laporan keuangan perusahaan perbankan yang terdaftar di Bursa Efek Indonesia. Sampel dalam penelitian ini adalah laporan keuangan perusahaan perbankan yang terdaftar di Bursa Efek Indonesia dari tahun 2014-2016. Penelitian ini mengunakan statistik deskriptif, uji t dan uji F. Hasil penelitian ini ukuran perusahaan secara parsial berpengaruh signifikan terhadap ketepatan waktu pelaporan keuangan sedangkan profitabilitas dan leverage tidak berpengaruh signifikan terhadap ketepatan waktu pelaporan keuangan. Hasil uji F didapatkan nilai signifikan 0,025 <strong>&lt;</strong>0,05 yang menunjukkan secara simultan leverage, ukuran perusahaan, dan profitabilitas berpengaruh secara signifikan terhadap ketepatan waktu pelaporan keuangan.</p>
KARAKTERISTIK COKELAT FILLING KACANG METE YANG DIPENGARUHI JENIS DAN JUMLAH LEMAK NABATI
Authors: Sutrisno Asep Dedy 
Published: July 2018

Tujuan dari penelitian ini adalah untuk mempelajari dan mengetahui karakteristik cokelat filling kacang mete (Anacardium occidentale L.) yang dipengaruhi jenis dan jumlah lemak nabati. Penelitian ini diharapkan dapat memberikan informasi mengenai pengaruh penggunaan jenis lemak nabati dan jumlah lemak nabati dalam pembuatan cokelat filling kacang mete (Anacardium occidentale L.). Diharapkan dapat memberikan informasi pengembangan teknologi, pengolahan dan wawasan yang luas dalam membuat produk cokelat filling kacang mete (Anacardium occidentale L.), serta memberikan informasi mengenai pengaruh proses pengolahan terhadap neraca bahan komponen lemak. Rancangan percobaan yang digunakan dalam penelitian ini adalah pola faktorial 3 x 3 dalam Rancangan Acak Kelompok (RAK) dan ulangan yang dilakukan sebanyak tiga kali. Pola percobaan faktorial tersebut terdiri dari dua faktor, yaitu : faktor A (jenis lemak nabati) terdiri dari 3 taraf yaitu : cocoa butter (a1), vegetable shortening (a2) dan margarin (a3) dan faktor B (jumlah lemak nabati) terdiri dari 3 taraf yaitu: 25% (b1), 20% (b2) dan 15% (b3). Hasil analisis dan perhitungan statistik pada penelitian utama menunjukkan faktor A (jenis lemak nabati) berpengaruh terhadap kadar lemak, titik leleh, tekstur, titik beku, rasa, dan aroma. Faktor B (jumlah lemak nabati) berpengaruh terhadap kadar lemak, titik leleh, dan tekstur. Interaksi antara faktor A (jenis lemak nabati) dan B (jumlah lemak nabati) berpengaruh terhadap titik leleh.
The Spectroscopic and theoretical investigations of complex formation of (3E,3'E)-7,7'-(carbonylbis(azanediyl))bis(3-(2-(2-hydroxyphenyl)hydrazono)-4-oxo-3,4-dihydronaphthalene-2-sulfonic acid) with metal cations
Authors: Kovalchukova Olga , Ryabov Mikhael , Obmenennaya Alexandra , Popandopulo Nikolai 
Published: July 2018

A novel azo-dye was isolated by a diazo-coupling reaction and characterized by the elemental analysis, mass spectra, IR and UV-VIS spectroscopy. The processes of complex formation of H4L with some mono-, bis-, and trivalent metal cations were studied by spectrophotometric titration and theoretical modeling. The NBO effective charge calculations indicate a strong covalent character of the coordination bonds at complexation.
Eriştenin Farklı Un Katkıları ile Zenginleştirilmesi
Authors: METE Merve , DÜLGER ALTINER Dilek 
Published: July 2018

Gıdalarda zenginleştirme hiç bulunmayan veya eksik
bulunan bir veya birden fazla besin öğesinin eklenmesi ve özeliklerinin
geliştirilmesidir. Gıdaların fonksiyonel, besleyici ve duyusal kalite
özelliklerinin araştırılmasına yönelik çalışmalar gün geçtikçe artmaktadır.
Erişte, besleyici özelliğinin yanı sıra, düşük maliyetli ve yapım
teknolojisinin basit olması ve uzun süre muhafaza edilebilir olmasından dolayı,
zenginleştirme için uygun bir yarı hazır gıda maddesidir. Fonksiyonel erişte
üretiminde meyve, sebze unları, baklagiller, protein konsantreleri, vitaminler
ve mineraller gibi maddeler ilave edilerek zenginleştirmeye gidilmiştir. Bu derlemede,
eriştenin besleyici, tekstürel ve diyet lif özelliklerini geliştirmeye yönelik
çeşitli çalışmalar ve farklı un katkıları ile eriştenin zenginleştirilmesi anlatılmıştır.&nbsp;
Peran Tokoh Agama dalam Pembinaan Harmonisasi Kehidupan dan Akhlak Masyarakat di Kota Metro Lampung
Authors: Umami Ida 
Published: July 2018

Religious figures basically have a very important and strategic position and role, mainly as a spiritual, moral and ethical foundation in the life and life of mankind. a religious figure is a figure or role model in society. Has a position and great influence in the midst of society, because it has advantages, both in science, integrity, and so forth. Religious figures also serve as community leaders, as priests in religious matters and community issues and state affairs in order to succeed government programs and foster community life harmonization. Religion as a value system must be understood, lived and practiced by all adherents in the life order of every individual, family and society and animates the life of the nation and the state. The current situation of harmonization and community behavior requires the role of religious leaders to be significantly expected to take the initiative in the development and development of morality. This means that every development effort must always be directed to have a positive impact on character development.
Keyword: Religious figures and character development
On the Symmetric Block Design with Parameters (306,61,12) Admitting a Group of Order 61
Authors: Gashi Menderes 
Published: July 2018

In this paper we have proved that up to isomorphism there are exactly two orbitÂ structures for a putative symmetric block design D with parameters (306,61,12), constructed byÂ group G of order 61. Also the full automorphism groups for these orbit structures are given.
Pride and Passion: Remarks on Thomas L. Saatyâ€™s Final Papers
Authors: Ã‡etin EyÃ¼p , Kiremitci BarÄ±ÅŸ 
Published: July 2018

Thomas L. Saaty, a world-renowned scholar and our beloved Advisory Editor, passed away on August 14, 2017 at the age of 91. Â He has made many fundamental contributions to operations research, analytics, business and mathematics. Despite his heavy illness for 14 months, as passionate about science, he has also enthusiastically published his research. We review his final works published in 2017 and 2018. We are also honored to reveal and publish his final statements on neural firing and synthesis in making comparisons & life satisfaction, respectively, in his final two papers; the previous one submitted by him just before his passing and the other one submitted by his co-authors after his death to European Journal of Pure and Applied Mathematics (EJPAM).We just would like to remember and honor Saatyâ€™s memory by publishing his final papers at EJPAM and this humble remarks dedicated to the memory of Thomas L. Saaty on the occasion of the first anniversary of his passing, August 14, 2018.
Алгоритм програми індивідуалізації фізичної реабілітації дітей 14–17 років із вегето-судинними дисфункціями
Authors: Savchuk Olena 
Published: July 2018

Актуальність теми дослідження зумовлена відсутністю комплексного підходу до оцінювання психофізичного стану учнів спеціальних медичних груп із вегето-судинними дисфункціями, що не виконує повною мірою оздоровчих завдань освіти в умовах навчального процесу закладів загальної середньої освіти. Мета й методи роботи. Мета роботи – підвищити ефективність оздоровчих завдань освіти в умовах навчального процесу закладів загальної середньої освіти для дітей 14–17 років із вегето-судинними дисфункціями за допомогою розробки алгоритму програми індивідуалізації фізичної реабілітації дітей цієї групи. Проаналізовано навчальні програми та науково-методичну літературу щодо підходів до фізичної реабілітації дітей 14–17 років із вегето-судинними дисфункціями в умовах навчальних закладів загальної середньої освіти. Із метою вивчення сучасних проблем організації навчального процесу дітей спеціальних медичних груп проведено спостереження за перебігом процесів навчання на уроках фізичної культури для дітей 8–11 класів закладів загальної середньої освіти м. Суми. Використано методи симпліфікації та диференціації до процесу побудови алгоритму індивідуалізації програми фізичної реабілітації. Результати роботи та висновки. Розроблено алгоритм та схему програми індивідуалізації фізичної реабілітації дітей 14–17 років із вегето-судинними дисфункціями в умовах закладів загальної середньої освіти, що реалізують індивідуальний підхід через визначення рівня інтегрального показника вегето-судинної дисфункції й індивідуальних для кожної дитини складових частин ризику розвитку вегето-судинної дисфункції (психогенної, соматичної, ризику виникнення вегето-судинної дисфункції під впливом чинників життєдіяльності). Запропоновані алгоритм та схема програми індивідуалізації фізичної реабілітації дітей 14–17 років із вегето-судинними дисфункціями в умовах закладів загальної середньої освіти дадуть змогу здійснювати індивідуальний підхід на основі кількісної оцінки донозологічних станів, покращення моніторингу стану здоров’я школярів, програм закріплення форм рухової активності.