bluuebunny/crossref_metadata_2025_split huggingface dataset:
Condições da Saúde Bucal de Escolares de 12 anos na Cidade de Ibicuí, Bahia, 2011
Authors: Carvalho Juliana Souza , Dourado Priscila Cunha , Lima Matheus Silva , Silva Ricardo Araúdo , Almeida Tatiana Frederco 
Published: April 2018

<p class="MsoNormal" style="text-align: justify; line-height: 200%;"><span style="line-height: 20px;">Introdução: os estudos epidemiológicos têm como objetivo contribuir para a melhoria da saúde das populações e permitir através dos </span><span style="line-height: 20px;">resultados encontrados e dos conhecimentos adquiridos o direcionamento de políticas de saúde públicas mais adequadas. Objetivo: </span><span style="line-height: 20px;">descrever as condições de saúde bucal dos escolares de 12 anos das instituições públicas da cidade de Ibicuí-BA. Metodologia: os </span><span style="line-height: 20px;">escolares foram examinados na própria escola conforme os critérios do SB Brasil 2010. Análises descritivas foram realizadas. No total </span><span style="line-height: 20px;">participaram deste estudo 247 escolares. Discussão: o índice CPO-D apresentou resultado igual a 1,87. Avaliando a necessidade de </span><span style="line-height: 20px;">tratamento nesse grupo, identificou-se que 50,20% dos escolares não necessitavam de nenhum tratamento em nenhuma unidade </span><span style="line-height: 20px;">dentária. Vinte e nove vírgula vinte e cinco por cento dos indivíduos apresentou algum tipo de fluorose. Ao analisar a presença de </span><span style="line-height: 20px;">traumatismo dentário neste grupo, verificou-se que 8,93% das crianças já haviam sofrido algum tipo de injúria dental. Já as alterações </span><span style="line-height: 20px;">periodontais foram mais encontradas na zona rural do que na zona urbana. Conclusão: a condição de saúde bucal dos escolares de 12 </span><span style="line-height: 20px;">anos da cidade de Ibicuí é considerada insatisfatória, necessitando de tratamento odontológico curativo e preventivo. A Epidemiologia </span><span style="line-height: 20px;">pode contribuir para o planejamento de ações mais efetivas voltadas para este grupo.</span></p>
EVIDENCIAÇÃO DOS FATORES DE RISCOS NAS EMPRESAS BRASILEIRAS E AMERICANAS DO SETOR DE PAPEL E CELULOSE
Authors: Vogt Mara , Brighenti Josiane , Guse Jaqueline Carla , Fernandes Francisco Carlos 
Published: April 2018

<p>O objetivo deste estudo consiste em verificar os fatores de risco evidenciados nas empresas brasileiras e americanas do setor de papel e celulose. Para tanto, realizou-se uma pesquisa descritiva, qualitativa e documental. A população do estudo refere-se a todas as empresas brasileiras e americanas de capital aberto do setor de papel e celulose e, a amostra foi composta por seis empresas brasileiras e sete empresas americanas. O período de análise compreende o ano de 2013. Os resultados encontrados demonstram que as empresas brasileiras evidenciam os fatores de risco relacionados à companhia, ao controlador direto ou indireto, ou grupo de controle, aos acionistas, às controladas e coligadas, aos fornecedores, aos clientes, ao setor de atuação, à regulação do setor de atuação e aos países estrangeiros. Já as empresas americanas evidenciam fatores relacionados às companhias, aos clientes, à concorrência, à regulação do setor de atuação e à segurança dos sistemas de informação. </p>
RECONHECIMENTO DOS ATIVOS INTANGÍVEIS NAS COMBINAÇÕES DE NEGÓCIOS: UMA ANÁLISE NAS CARACTERÍSTICAS DAS COMPANHIAS DE CAPITAL ABERTO BRASILEIRAS NO PERÍODO ENTRE 2012 E 2014
Authors: Eloy Juliana Cordeiro Campodonio , De Souza Maíra Melo 
Published: April 2018

<p>Este estudo tem por objetivo identificar as características dos ativos intangíveis reconhecidos nas combinações de negócios e sua relação com as características das companhias de capital aberto brasileiras no período entre 2012 e 2014. Para alcançar o objetivo foi elaborada uma lista de verificação com base no CPC 15 (R1) elencando as características dos ativos intangíveis adquiridos e também foram analisadas as seguintes características das companhias: proporção do <em>goodwill</em> em relação à contraprestação, o índice de rentabilidade, se negocia <em>American Depositary Receipt</em> (ADRs) na <em>New York Stock Exchange</em> (NYSE), nível de governança corporativa e o setor de atuação. Em relação aos resultados, observou-se que na maior parte das combinações de negócios houve o reconhecimento do <em>goodwill, </em>o que sugere que existe uma tendência de não reconhecimento de intangíveis identificáveis nas combinações de negócios analisadas. Na maioria das combinações de negócios não foram especificados os fatores que formam o <em>goodwill</em> adquirido.</p><p> </p>
Development of the American College of Rheumatology Electronic Clinical Quality Measures for Gout
Authors: FitzGerald John D. , Mikuls Ted R. , Neogi Tuhina , Singh Jasvinder A. , Robbins Mark , Khanna Puja P. , Turner Amy S. , Myslinski Rachel , Suter Lisa G. 
Published: April 2018

ObjectiveElectronic clinical quality measures (eCQMs) are increasingly used by health registries and third parties to evaluate and improve the quality of health care. To complete these eCQMs, data are extracted from electronic health records (EHRs). The treatment of gout has been an area identified with gaps in quality of care. On behalf of the American College of Rheumatology (ACR), we sought to develop and test eCQMs to evaluate gout care.MethodsDrawing from the 2012 ACR gout guidelines, a working group developed candidate gout process measures that were evaluated by an interdisciplinary panel of health care stakeholders, the ACR Quality Measures Subcommittee (QMS), and ultimately the ACR Board of Directors for formal validity testing. For each of the selected gout eCQMs, 3 clinical sites using different EHR systems tested the scientific feasibility and validity of the measures. Measures appropriate for accountability were presented for national endorsement.ResultsOf the 10 proposed eCQMs, 4 were endorsed by the ACR QMS, 3 were incorporated into the ACR's Rheumatology Informatics System for Effectiveness (RISE) Registry, and 2 were endorsed by the National Quality Forum. The 3 eCQMs incorporated into RISE (evaluating indications for urate‐lowering therapy [ULT]), monitoring serum urate, and treat‐to‐target outcome) demonstrated high validity and reliability. Proportions of patients passing these 3 eCQMs in RISE and at the 3 clinical testing sites ranged between 32% and 58%, indicating significant room for improvement in care.ConclusionThree eCQMs have been validated and implemented into RISE. Two of these measures (evaluating indications for ULT and monitoring serum urate) are available for use in federal quality reporting programs. Performance on these measures suggests there is significant room for improvement in the management of gout.
Lipid Testing and Statin Prescriptions Among Medicaid Recipients With Systemic Lupus Erythematosus or Diabetes Mellitus and the General Medicaid Population
Authors: Chen Sarah K. , Barbhaiya Medha , Fischer Michael A. , Guan Hongshu , Lin Tzu‐Chieh , Feldman Candace H. , Everett Brendan M. , Costenbader Karen H. 
Published: April 2018

ObjectiveCardiovascular disease (CVD) risks in systemic lupus erythematosus (SLE) are similar to those in diabetes mellitus (DM). We investigated whether the numbers of lipid tests and statin prescriptions in patients with SLE are comparable with those in patients with DM and those in individuals without either disease.MethodsUsing Analytic eXtract files from 29 states for 2007–2010, we identified a cohort of US Medicaid beneficiaries, ages 18–65 years, with prevalent SLE. Each SLE patient was matched for age and sex with 2 patients with DM and 4 individuals in the general Medicaid population who did not have either SLE or DM. We compared the proportions of patients in each cohort who received ≥1 lipid test and ≥1 statin prescription during 1‐year follow‐up. We used multivariable logistic regression to calculate the odds of lipid testing and receiving prescriptions for statins and conditional logistic regression to compare the matched cohorts.ResultsWe identified 3 Medicaid cohorts: 25,950 patients with SLE, 51,900 patients with DM, and 103,800 Medicaid recipients without either condition. In these cohorts, lipid testing was performed in 24% of patients in the SLE group, 43% of patients in the DM group, and 16% of individuals in the group with neither condition, and statin prescriptions were dispensed in 11%, 33%, and 7% of these groups, respectively. SLE patients were 66% less likely (odds ratio [OR] 0.34, 95% confidence interval [95% CI] 0.34–0.35) to have lipid tests and 82% less likely (OR 0.18, 95% CI 0.18–0.18) to fill a statin prescription compared with DM patients. SLE patients were also less likely (OR 0.89, 95% CI 0.84–0.94) to fill a statin prescription compared with individuals in the general Medicaid population.ConclusionDespite having an elevated risk of CVD, SLE patients received less lipid testing and received fewer statin prescriptions compared with age‐ and sex‐matched DM patients and individuals in the general Medicaid population; this gap should be a target for improvement.
Rhodium‐Catalyzed Direct and Selective ortho C−H Chalcogenation of N‐(Hetero)aryl‐7‐azaindoles
Authors: Vats Tripta Kumari , Mishra Aniket , Deb Indubhusan 
Published: April 2018

AbstractRhodium catalyzed synthesis of chalcogenated N‐aryl‐7‐azaindoles/azaindolines has been developed through N‐directed ortho Csp2−H activation in presence of silver triflate and silver carbonate in 1,4‐dioxane using dichalcogenides. We have established this methodology as being efficient, highly regioselective and scalable, having a broad substrates scope. Through this route, a range of substrates have furnished thiolation and selenylation of azaindoles and azaindolines in good to excellent yields. These molecules could have potential application in biological and/or material science.magnified image
Synergistic Effect of B and N Dopants in Catalytic Transfer Hydrogenation
Authors: Zhang Yunrui , Zhai Yingying , Chu Minzhe , Huo Li , Wang Haijun , Gao Yongjun 
Published: April 2018

AbstractA B,N‐codoped carbon material (BNC) was prepared by a simple method and employed as a metal‐free catalyst in the transfer hydrogenation of nitroarenes in aqueous solution. In the preparation of the BNC, boric acid not only functions as the template during the carbonization step but also serves as the source for the B dopant in the final BNC product. Nitrilotriacetic acid (NTA) serves as the carbon and nitrogen source for the system. Characterization of the intermediate materials prepared during the synthesis indicate that the boron nitride (BN) content of the BNC increases at higher calcination temperatures. The final B,N‐codoped carbon material showed excellent catalytic activity and high selectivity in the transfer hydrogenations of nitroarenes under moderate reaction conditions (52.1–100 % yield). Results of control experiments suggest that the BN domain of the BNC is a key factor to its catalytic activity. Density functional theory calculations show that boron atoms facilitate the adsorption and activation of the nitrobenzene and hydrazine molecules. Nitrogen atoms store the active hydrogen atoms that are generated during the catalytic process and transfer them to the nitroarene. This synergistic effect between the B and N dopants in the BN domain of the BNC was used to successfully promote the catalytic transfer hydrogenation of nitroarenes.
Endoscopic and external approaches for orbital decompression: an analysis of trends from a U.S. perspective
Authors: Svider Peter F. , Arianpour Khashayar , Nguyen Brandon , Hsueh Wayne D. , Langer Paul D. , Eloy Jean Anderson , Folbe Adam J. 
Published: April 2018

BackgroundAlthough the endoscopic approach has been increasingly utilized for a variety of sinonasal and skull base pathologies, there has been little inquiry into its adoption in the surgical management of orbital disease. Our objective was to evaluate nationwide temporal and geographic trends in approaches for orbital decompression.MethodsData available from the Centers for Medicare and Medicaid Services (CMS) were evaluated, focusing on the use of open and endoscopic approaches for orbital decompression (CPT codes 67414, 67445, 31292, and 31293) among Medicare beneficiaries over a 10‐year period. Regional data were also analyzed.ResultsThere were 8047 orbital decompressions billed to Medicare from 2007 to 2016. The number of external and endoscopic approaches increased by 73.0% and 29.2%, respectively, while the number of Medicare beneficiaries increased by 29.1%. Endoscopic decompression represented 23.5% of Medicare‐billed orbital decompressions in 2016 (221 of 939), down from 29.2% in 2007 (171 of 586). The South had the greatest proportion of decompressions utilizing an endoscopic approach (30.2%).ConclusionThere has not been a clear movement toward the endoscopic approach for orbital decompression, with modest growth when compared with external approaches. Potential explanations include the specialty‐exclusive nature of approaches, as well as a lack of consensus; the latter idea is further reinforced by geographic variation. High‐quality prospective trials may clarify the role of endoscopic approaches in these patients.
Amyloid‐β Peptide Induces Prion Protein Amyloid Formation: Evidence for Its Widespread Amyloidogenic Effect
Authors: Honda Ryo 
Published: April 2018

AbstractTransmissible spongiform encephalopathy is associated with misfolding of prion protein (PrP) into an amyloid β‐rich aggregate. Previous studies have indicated that PrP interacts with Alzheimer′s disease amyloid‐β peptide (Aβ), but it remains elusive how this interaction impacts on the misfolding of PrP. This study presents the first in vitro evidence that Aβ induces PrP‐amyloid formation at submicromolar concentrations. Interestingly, systematic mutagenesis of PrP revealed that Aβ requires no specific amino acid sequences in PrP, and induces the misfolding of other unrelated proteins (insulin and lysozyme) into amyloid fibrils in a manner analogous to PrP. This unanticipated nonspecific amyloidogenic effect of Aβ indicates that this peptide might be involved in widespread protein aggregation, regardless of the amino acid sequences of target proteins, and exacerbate the pathology of many neurodegenerative diseases.
Enantioselective Formal [3+2] Cycloaddition of Epoxides with Imines under Brønsted Base Catalysis: Synthesis of 1,3‐Oxazolidines with Quaternary Stereogenic Center
Authors: Kondoh Azusa , Akahira Shiori , Oishi Masafumi , Terada Masahiro 
Published: April 2018

AbstractThe formal [3+2] cycloaddition of epoxides and unsaturated compounds is a powerful methodology for the synthesis of densely functionalized five‐membered heterocyclic compounds containing oxygen. Described is a novel enantioselective formal [3+2] cycloaddition of epoxides under Brønsted base catalysis. The bis(guanidino)iminophosphorane as a chiral organosuperbase catalyst enabled the enantioselective reaction of β,γ‐epoxysulfones with imines, owing to its strong basicity and high stereocontrolling ability, to provide enantioenriched 1,3‐oxazolidines having two stereogenic centers, including a quaternary one, in a highly diastereo‐ and enantioselective manner.
Highly Efficient Supramolecular Catalysis by Endowing the Reaction Intermediate with Adaptive Reactivity
Authors: Jiao Yang , Tang Bohan , Zhang Yucheng , Xu Jiang‐Fei , Wang Zhiqiang , Zhang Xi 
Published: April 2018

AbstractA new strategy of highly efficient supramolecular catalysis is developed by endowing the reaction intermediate with adaptive reactivity. The supramolecular catalyst, prepared by host–guest complexation between 2,2,6,6‐tetramethylpiperidin‐1‐oxyl (TEMPO) and cucurbit[7]uril (CB[7]), was used for biphasic oxidation of alcohols. Cationic TEMPO+, the key intermediate, was stabilized by the electrostatic effect of CB[7] in aqueous phase, thus promoting the formation of TEMPO+ and inhibiting side reactions. Moreover, through the migration into the organic phase, TEMPO+ was separated from CB[7] and recovered the high reactivity to drive a fast oxidation of substrates. The adaptive reactivity of TEMPO+ induced an integral optimization of the catalytic cycle and greatly improved the conversion of the reaction. This work highlights the unique advantages of dynamic noncovalent interactions on modulating the activity of reaction intermediates, which may open new horizons for supramolecular catalysis.
Crowdsourcing as an Analytical Method: Metrology of Smartphone Measurements in Heritage Science
Authors: Brigham Rosie , Grau‐Bové Josep , Rudnicka Anna , Cassar May , Strlic Matija 
Published: April 2018

AbstractThis research assesses the precision, repeatability, and accuracy of crowdsourced scientific measurements, and whether their quality is sufficient to provide usable results. Measurements of colour and area were chosen because of the possibility of producing them with smartphone cameras. The quality of the measurements was estimated experimentally by comparing data contributed by anonymous participants in heritage sites with reference measurements of known accuracy and precision. Participants performed the measurements by taking photographs with their smartphones, from which colour and dimensional data could be extracted. The results indicate that smartphone measurements provided by citizen scientists can be used to measure changes in colour, but that the performance is strongly dependent on the measured colour coordinate. The same method can be used to measure areas when the difference in colour with the neighbouring areas is large enough. These results render the method useful in some heritage science contexts, but higher precision would be desirable.
Modulating the Folding Landscape of Superoxide Dismutase 1 with Targeted Molecular Binders
Authors: Bunck David N. , Atsavapranee Beatriz , Museth Anna K. , VanderVelde David , Heath James R. 
Published: April 2018

AbstractAmyotrophic lateral sclerosis, or Lou Gehrig's disease, is characterized by motor neuron death, with average survival times of two to five years. One cause of this disease is the misfolding of superoxide dismutase 1 (SOD1), a phenomenon influenced by point mutations spanning the protein. Herein, we used an epitope‐specific high‐throughput screen to identify a peptide ligand that stabilizes the SOD1 native conformation and accelerates its folding by a factor of 2.5. This strategy may be useful for fundamental studies of protein energy landscapes as well as designing new classes of therapeutics.
Kinetic Resolution of α‐Hydroxy‐Substituted Oxime Ethers by Enantioselective Cu−H‐Catalyzed Si−O Coupling
Authors: Dong Xichang , Kita Yuji , Oestreich Martin 
Published: April 2018

AbstractA catalyst‐controlled enantioselective alcohol silylation by Cu−H‐catalyzed dehydrogenative Si−O coupling of hydroxy groups α to an oxime ether and simple hydrosilanes is reported. The selectivity factors reached in this kinetic resolution are generally high (s≈50), and these reactions thereby provide reliable access to highly enantioenriched α‐hydroxy‐substituted oxime ethers. The synthetic usefulness of these compounds is also demonstrated.
Triphenylamine‐Appended Half‐Sandwich Iridium(III) Complexes and Their Biological Applications
Authors: He Xiangdong , Tian Meng , Liu Xicheng , Tang Yanhua , Shao Chang Fang , Gong Peiwei , Liu Jinfeng , Zhang Shumiao , Guo Lihua , Liu Zhe 
Published: April 2018

AbstractOrganometallic half‐sandwich IrIII complexes of the type [(η5‐Cpx)Ir(N^N)Cl]PF6 (Cpx: Cp* or its phenyl Cpxph or biphenyl Cpxbiph derivatives; N^N: triphenylamine (TPA)‐substituted bipyridyl ligand groups) were synthesized and characterized. The complexes showed excellent bovine serum albumin (BSA) and DNA binding properties and were able to oxidize NADH to NAD+ (NAD=nicotinamide adenine dinucleotide) efficiently. The complexes induced apoptosis effectively and led to the emergence of reactive oxygen species (ROS) in cells. All complexes showed potent cytotoxicity with IC50 values ranging from 1.5 to 7.1 μm toward A549 human lung cancer cells after 24 hours of drug exposure, which is up to 14 times more potent than cisplatin under the same conditions.
Synthesis of 1,1′‐Spirobiindane‐7,7′‐Disulfonic Acid and Disulfonimide: Application for Catalytic Asymmetric Aminalization
Authors: Kurihara Takumaru , Satake Shun , Hatano Manabu , Ishihara Kazuaki , Yoshino Tatsuhiko , Matsunaga Shigeki 
Published: April 2018

Abstract1,1′‐Spirobiindane‐7,7′‐disulfonic acid (SPISA) and 1,1′‐spirobiindane‐7,7′‐disulfonimide were synthesized from 1,1′‐spirobiindane‐7,7′‐diol (SPINOL) in 4 steps using a Pd‐catalyzed Newman–Kwart rearrangement as a key step. These new catalysts possessing a rigid spirocyclic backbone were evaluated in a catalytic asymmetric aminalization reaction, and SPISA/iPr2NEt exhibited high enantioselectivity, demonstrating the utility of SPISA as a chiral Brønsted acid catalyst.
An Active Palladium Colloidal Catalyst for the Selective Oxidative Heterocoupling of (Hetero)Aryl Boronic Acids
Authors: Sable Vaibhav , Maindan Karan , Bhilare Shatrughn , Chrysochos Nicolas , Schulzke Carola , Kapdi Anant R. 
Published: April 2018

AbstractA highly selective oxidative heterocoupling protocol for (hetero)aryl boronic acids with an active palladium colloidal catalyst was developed. The judicious choice of electronically different aryl boronic acids made possible such couplings under mild conditions, with air as oxidant, while embracing a wide substrate scope. This successful approach further allowed the development of a unique one‐pot sequential oxidative heterocoupling/Suzuki–Miyaura cross‐coupling tandem process for accessing substituted terphenyls.
Pinning Consensus Analysis for Nonlinear Second‐Order Multi‐Agent Systems with Time‐Varying Delays
Authors: Zhang Dandan , Song Qiang , Liu Yang , Cao Jinde 
Published: April 2018

AbstractThis paper considers the second‐order leader‐following consensus problem for adelayed multi‐agent systems under general network topologies, in which each agent is a time‐delayed second‐order system with inherent nonlinear dynamics. Based on the pinning control strategy, a distributed control algorithm is proposed to achieve the second‐order leader‐following consensus of multi‐agent systems. Using matrix theory, algebraic graph theory and the free‐weighting‐matrix approach, some sufficient conditions are established in terms of linear matrix inequalities to ensure that all the agents can asymptotically follow the virtual leader. Finally, the effectiveness and the advantages of the developed approach are illustrated by means of simulations.
Optimal non‐blocking decentralized supervisory control with unobservable controllable events
Authors: Saeidi Vahid , Afzalian Ali A. , Gharavian Davood 
Published: April 2018

AbstractParanormality is an observation property of a language, in which the occurrence of unobservable events never exits the closure of the language. In this paper, a synthesis method is proposed to construct a paranormal supervisor. We propose a method to construct a controllable language such that the occurrence of unobservable events does not exit the closure of the controllable language. Moreover, a new observation property, that is, Quasi Output Control Consistency (QOCC) is defined to construct the optimal (least restrictive) non‐blocking decentralized supervisory control in the presence of unobservable controllable events. Using QOCC and natural observer properties, we propose a method to construct a normal supervisor such that an arbitrary pair of lookalike strings are initiated and terminated with identical observable and uncontrollable events. It is assumed that one of these strings has unobservable controllable events. An OCC property is defined in the literature as a special case of QOCC property, where none of the lookalike strings has unobservable controllable events.