bluuebunny/crossref_metadata_2025_split huggingface dataset:
CO2‐Cross‐Linked Frustrated Lewis Networks as Gas‐Regulated Dynamic Covalent Materials
Authors: Chen Liang , Liu Renjie , Hao Xiang , Yan Qiang 
Published: November 2018

AbstractThe design of structurally dynamic molecular networks can offer strategies for fabricating stimuli‐responsive adaptive materials. Herein we first report a gas‐responsive dynamic gel system based on frustrated Lewis pair (FLP) chemistry. Two trefoil‐like molecules with bulky triphenylborane and triphenylphosphine groups are synthesized as complementary Lewis acid and base with trivalent sites. They can together bind CO2 gas molecules and further form a cross‐linked network via the bonding interactions between FLPs and CO2. Such CO2‐bridged dative linkages are shown to be dynamic covalent bonds, which endow the frustrated Lewis network with adaptable behaviors and unprecedented gas‐regulated viscoelastic, mechanical, and self‐healing performance. This study is an initial attempt to apply the FLP concept in materials chemistry, but we believe that this strategy will open a promising future for gas‐sensitive smart materials.
Zinc(II)‐Dipicolylamine Coordination Nanotheranostics: Toward Synergistic Nanomedicine by Combined Photo/Gene Therapy
Authors: Chu Chengchao , Ren En , Zhang Yunming , Yu Jingwen , Lin Huirong , Pang Xin , Zhang Yang , Liu Heng , Qin Zainen , Cheng Yi , Wang Xiaoyong , Li Wei , Kong Xiangjian , Chen Xiaoyuan , Liu Gang 
Published: November 2018

AbstractWe report the rational design of coordination‐driven self‐assembly metal–organic nanostructures for multifunctional nanotheranostics. Zinc(II) coordination‐based nano‐formulations capable of loading indocyanine green (ICG) and therapeutic genes were prepared to achieve a fluorescence/photoacoustic imaging‐guided combination photo/gene therapy strategy. We showed the enhanced theranostic capability of zinc(II)‐dipicolylamine‐assisted assembly of ICG, as well as simultaneous targeted gene delivery in an experimental mouse model of cancer. Such a co‐assembly strategy provides a facile way to achieve combined therapeutic functions for personalized nanomedicine.
Enhanced visible‐light‐driven photocatalytic activity of F doped reduced graphene oxide ‐ Bi2WO6 photocatalyst
Authors: Yu Hongguang , Chu Chenglin , An Xulong 
Published: November 2018

The reduced graphene oxide‐Bi2WO6 (rGO‐BWO) photocatalysts with the different RF/O values (molar ratio of the F molar mass and the O's molar mass of Bi2WO6) had been successfully synthesized via one‐step hydrothermal method. The F‐doped rGO‐BWO samples were characterized by X‐ray diffraction patterns (XRD), field‐emission scanning electron microscopy (FE‐ESEM), transmission electron microscopy (TEM), Brunauer–Emmett–Teller surface area (BET), X‐ray photoelectron spectroscopy (XPS) and UV–vis diffuse reflectance spectra (DRS). The results indicate that F− ions had been successfully doped into rGO‐BWO samples. With the increasing of the RF/O values from 0 to 2%, the evident change of the morphology and the absorption edges of F‐doped rGO‐BWO samples and the photocatalytic activities had been enhanced. Moreover, the photocatalytic activity of F‐doped rGO‐BWO with RF/O = 0.05 were better than rGO‐BWO and the other F‐doped rGO‐BWO under 500 W Xe lamp light irradiation. The enhanced photocatalytic activity can be attributed to the morphology of the intact microsphere that signify the bigger specific surface area for providing more possible reaction sites for the adsorption–desorption equilibrium of photocatalytic reaction, the introduction of F− ions that may cause the enhancement of surface acidity and creation of oxygen vacancies under visible light irradiation, the narrower band gap which means needing less energy for the electron hole pair transition.
In vivo Visualization of the Process of Hg2+ Bioaccumulation in Water Flea Daphnia carinata by a Novel Aggregation‐Induced Emission Fluorogen
Authors: He Tao , Ou Weixin , Tang Ben Zhong , Qin Jianguang , Tang Youhong 
Published: November 2018

AbstractThis paper employs a specially designed aggregation‐induced emission fluorogen (AIEgen) to in vivo visualize the process of Hg2+ bioaccumulation in a common species of freshwater zooplankton Daphnia carinata (D. carinata) by two methods, direct Hg2+ absorption and ingestion of Hg2+ contaminated food. We analysed the relevance between photoluminescence (PL, I595/I480) ratios and Hg2+ (CHg2+) and developed the master curve for Hg2+ determination based on measuring the PL intensity of the solution. Meanwhile, fluorescent image analysis showed that the major recipient organs of Hg2+ in D. carinata were the compound eyes and carapace, followed by the intestine and shell gland, but not the brain or heart. The response of D. carinata to Hg2+ via uptake from surrounding water differed distinctly from that through food intake of the algae (Euglena gracilis) contaminated by mercury. When Hg2+ was encapsulated by algae membrane, no fluorescence was detected, and the carapace morphology remained intact after ingesting algae for 80 min, in contrast to the rapid carapace deformation by direct Hg2+ absorption. The D. carinata showed higher mortality by direct Hg2+ immersion than via food ingestion. The reason for the high mortality after Hg2+ immersion was possibly due to carapace deformity after chemical reaction between chitin and mercury, but the biochemical pathway leading to morality needs further study.
Carbon dots‐involved chemiluminescence: Recent advances and developments
Authors: Wang Dong Mei , Lin Ke Li , Huang Cheng Zhi 
Published: November 2018

AbstractIn recent years, more and more nanomaterials‐based chemiluminescence (CL) systems have appeared to improve the sensitivity and expand the scope of the analytical applications with the explosive growth and development of nanomaterials and technology. As a fascinating class of luminescent carbon nanomaterials, carbon dots (CDs) are now substantially studied in fabricating CL based assays due to their unique optical and mechanical properties. Herein, we summarize and highlight the current developments of CDs‐involved weak or ultraweak CL systems, as well as the corresponding mechanisms and proper applications in some fields. CDs can take part in the CL reactions as oxidants, emitting species directly involved in redox oxidation, energy acceptors of CL energy transfer, or even catalysts involving other luminophores. In fact, they always have more than one role in many cases, owing to the formation of various excited species with short life in CL systems. Therefore, in this review article, the most recent progress of the different CDs‐assisted CL systems including the mechanisms and applications are presented. Finally, the conclusions and future prospects of this field are also discussed. The significant features of the CDs‐based CL systems may open up new prospects and challenges in a wider range of fields.
Simple determination of plasma ibrutinib concentration using high‐performance liquid chromatography
Authors: Yasu Takeo , Momo Kenji , Yasui Hiroshi , Kuroda Seiichirou 
Published: November 2018

AbstractIbrutinib is an oral inhibitor of Bruton tyrosine kinase, which is one of the key drugs used for the treatment of chronic lymphocytic leukemia and mantle cell lymphoma. In this study, we aimed to develop a simple method for determining plasma ibrutinib concentration. The analysis required extraction of a 200 μL plasma sample and precipitation of proteins using solid‐phase extraction. Ibrutinib and nilotinib, which was used as an internal standard, were separated using high‐performance liquid chromatography (HPLC) using a mobile phase of acetonitrile–0.5% monopotassium phosphate (KH2PO4, pH 3.0; 52:48, v/v) on a Capcell Pack C18 MG II (250 × 4.6 mm) monitored at 260 nm, at a flow rate of 1.0 mL/min. The calibration curve was linear at the plasma concentration range of 10–500 ng/mL with a coefficient of determination (r2) of 0.9999. The coefficients of intra‐day and inter‐day validation were 4.0–6.6 and 2.6–7.7%, respectively. The assay accuracy was −4.4–8.6%, and the recovery was >84%. This HPLC method coupled with ultraviolet (UV) detection for determining ibrutinib plasma concentration has several advantages such as simplicity and applicability to routine therapeutic drug monitoring at hospital laboratories.
In the eye of the beholder: The role of cognitive style and similarity in the evaluation of brand extensions
Authors: de Groote Julia K. , Mendini Monica , Gibbert Michael 
Published: November 2018

AbstractFit has been identified as an antecedent of the success of brand extensions. Recently, a new stream of literature has distinguished two different types of fit: feature‐based taxonomic similarity and relation‐based thematic similarity. Although researchers in this field have investigated how thematic and taxonomic brand extensions are evaluated, they have not accounted for interindividual differences in these evaluations. To address this gap, we investigate how cognitive styles are related to the evaluation of brand extensions that are based on different types of similarity. We show that a systematic cognitive style is related to the evaluation of taxonomic brand extensions. Moreover, we take the first steps to disentangle the relationship between intuitive cognitive style and the evaluation of thematic brand extensions, and we show that positive affect might play an important role as a moderator in these cases. The results provide us with a better understanding of how interindividual differences in information processing might account for differences in preferences for different types of brand extensions and, hence, consumer behavior.
Exploiting the Cellular Redox‐Control System for Activatable Photodynamic Therapy
Authors: Gharibi Nima , Kailass Karishma , Beharry Andrew A. 
Published: November 2018

AbstractPhotodynamic therapy (PDT) has been successfully used to treat a variety of cancers. However, one drawback has been the adverse side effects experienced by patients during therapy, as a result of the destruction of normal tissues upon irradiation. Herein, we describe the design, synthesis and characterisation of a photosensitiser to overcome this issue that, in addition to light, is also dependent on the overactive redox system present in cancer cells for its activation. Our probe consists of the photosensitiser, protoporphyrin IX, and a FRET‐based quencher dye, BHQ‐3, on a scaffold containing a disulfide bond. The close proximity of BHQ‐3 to protoporphyrin IX quenches its ability to fluoresce and produce reactive oxygen species, whereas nonenzymatic or enzymatic reduction can recover its native properties. We further demonstrate its ability to be activated in cancer cells in a thiol‐dependent manner and destroy breast and lung cancer cells upon red‐light irradiation.
Ingestible Contrast Agents for Gastrointestinal Imaging
Authors: Yang Xingyue , Lovell Jonathan F. , Zhang Yumiao 
Published: November 2018

AbstractGastrointestinal (GI) ailments cover a wide variety of diseases involving the esophagus, stomach, small intestine, large intestine, and rectum. They bring about many inconveniences in daily life in chronic diseases and can even be life threatening in acute cases. Rapid and safe detection approaches are essential for early diagnosis and timely management. Contrast agents for GI imaging can enhance contrast to distinguish abnormal lesions from normal structures. Computed tomography and magnetic resonance imaging are two important diagnostic tools for the evaluation of GI conditions. This review mainly involves several common GI diseases, including inflammatory diseases, intestinal tumors, diarrhea, constipation, and gastroesophageal reflux diseases. Selected contrast agents, such as barium sulfate, iodine‐based agents, gadolinium‐based agents, and others, are summarized. Going forward, continued endeavors are being made to develop more emerging contrast agents for other imaging modalities.
Retrospective longitudinal study of osteoporosis in adults with recessive dystrophic epidermolysis bullosa
Authors: Hubbard Lynne D. , Mayre‐Chilton Kattya 
Published: November 2018

Key Clinical MessageThis retrospective study looks at bone mineral density of people with recessive dystrophic epidermolysis bullosa as assessed by dual‐energy x‐ray absorptiometry. Data were collected in 34 patients aged 16‐35 years. Statistical analysis showed immobility, low body mass index, and pubertal delay was associated with osteoporosis.
Late T‐wave inversion following resolution of non‐ischemic acute pulmonary edema
Authors: Tampakis Konstantinos , Makris Nikolaos , Kontogiannis Christos , Spartalis Michael , Repasos Evangelos , Spartalis Eleftherios , Anninos Hector , Paraskevaidis Ioannis 
Published: November 2018

Key Clinical MessageElectrocardiographic (ECG) changes occurring several hours after the onset of acute cardiogenic pulmonary edema have been seldom described. The proposed explanatory mechanisms are various and not fairly established. In the absence of significant coronary artery disease, these ECG abnormalities could be attributed to mechanisms implicated in coronary microcirculatory dysfunction.
A patient with solid gynecologic cancer causing lactic acidosis, severe hypercalcemia, and hypoglycemia
Authors: Hausken John , Haave Ellen M. , Haugaa Håkon , Løberg Else M. , Kongsgaard Ulf E. 
Published: November 2018

Key Clinical MessageThough rare in cervical cancer patients, paraneoplastic syndrome usually presents with several endocrine and hormonal symptoms. Knowledge of the pathophysiology that underlies these abnormalities is beneficial to diagnosis and treatment. An interdisciplinary approach and test analysis prior to initiating specific treatment is recommended, though prognosis appears poor in advanced cases.
Acute‐on‐chronic food protein‐induced enterocolitis syndrome in an exclusively breast‐fed infant
Authors: Ntoumpara Maria , Sotiriadou Fotini , Fotoulaki Maria 
Published: November 2018

Key Clinical MessageFood protein‐induced enterocolitis syndrome (FPIES) is a non‐IgE‐mediated gastrointestinal food hypersensitivity disorder, typically provoked by cow's milk or soy in formula‐fed infants. This case shows that diagnosis of FPIES should be suspected in exclusively breast‐fed infants and pediatricians should be suspicious of this in infants with shock and sepsis.
Polyglandular syndrome type 2 in a Mexican family and its association with human leukocyte antigen
Authors: Bermeo‐Cabrera Janneth , Reza‐Albarrán Alfredo Adolfo , Granados Julio , Morales Juan José , González Jorge Alberto Gutiérrez , Doño Susana Hernández , Gutiérrez María Fernanda García 
Published: November 2018

Key Clinical MessageThe evaluation of first‐degree family members is very important to detect additional cases of polyglandular autoimmune syndrome type 2. The genetic evaluation of human leukocyte antigen (HLA) may be useful in the study of this syndrome. This study is the first report of an HLA study of this syndrome in a Mexican family.
Highly Enantioselective Transfer Hydrogenation of Prochiral Ketones Using Ru(II)‐Chitosan Catalyst in Aqueous Media
Authors: Szőllősi György , Kolcsár Vanessza Judit 
Published: November 2018

AbstractUnprecedentedly high enantioselectivities are obtained in the transfer hydrogenation of prochiral ketones catalyzed by a Ru complex formed in situ with chitosan chiral ligand. This biocompatible, biodegradable chiral polymer obtained from the natural chitin afforded good, up to 86 % enantioselectivities, in the aqueous‐phase transfer hydrogenation of acetophenone derivatives using HCOONa as hydrogen donor. Cyclic ketones were transformed in even higher, over 90 %, enantioselectivities, whereas further increase, up to 97 %, was obtained in the transfer hydrogenations of heterocyclic ketones. The chiral catalyst precursor prepared ex situ was examined by scanning electron microscopy, FT‐mid‐ and ‐far‐IR spectroscopy. The structure of the in situ formed catalyst was investigated by 1H NMR spectroscopy and using various chitosan derivatives. It was shown that a Ru pre‐catalyst is formed by coordination of the biopolymer to the metal by amino groups. This precursor is transformed in water insoluble Ru‐hydride complex following hydrogen donor addition. The practical value of the developed method was verified by preparing over twenty chiral alcohols in good yields and optical purities. The catalyst was applied for obtaining optically pure chiral alcohols at gram scale following a single crystallization.
Effect of Electrolyte Ions on the Stability of Flavin Adenine Dinucleotide‐Dependent Glucose Dehydrogenase
Authors: Nemoto Miki , Sugihara Kazunori , Adachi Tsubasa , Murata Kazuki , Shiraki Kentaro , Tsujimura Seiya 
Published: November 2018

AbstractThe thermal stability of flavin adenine dinucleotide‐dependent glucose dehydrogenase (FAD‐GDH) from Aspergillus terreus in phosphate buffer solution was substantially improved by kosmotropic ions, especially kosmotropic anions. The residual activity of FAD‐GDH in a 1.5 M sodium or ammonium sulfate solution remained more than 90 % after 60 min of heat treatment at 60 °C, while slight activity was observed for FAD‐GDH in a solution in the absence of additive sulfate ions. The stabilizing effect of the electrolytes was concentration‐dependent and strongly related to the structural stabilization of the enzyme, which involved enzyme compaction.
Chemometrics in instrumental analysis of complex systems—in honor and memory of Yi‐Zeng Liang
Authors: Zhang Zhimin , Li Hongdong , Yun Yonghuan , Ma Pan , Yi Lunzhao , Ren Dabing , Zhang Liangxiao , Yan Jun , Dong Naiping , Deng Baichuan , Lu Hongmei 
Published: November 2018

AbstractA true pioneer in the fields of chemometrics and analytical chemistry was lost with the passing of Yi‐Zeng Liang in October 2016. This is an enormous loss to both the local and global community of chemometrics. Yi‐Zeng Liang is recognized as one of the major players in China in the field of chemometrics. As a professor of chemometrics and analytical chemistry in Hunan University and Central South University, he made significant advances within instrumental analysis of complex systems. Liang inspired many students and visiting scholars. As Liang's former students, we have attempted to summarize Liang's contributions to the field over the past 30 years. This review covers different chemometric areas, signal preprocessing, multivariate curve resolution, and multivariate calibration and discusses the application of these methods in traditional Chinese medicine, metabolomics, proteomics, and quantitative structure‐activity relationship research.
The Shape of the Simplest Non‐proteinogenic Amino Acid α‐Aminoisobutyric Acid (Aib)
Authors: Alonso José L. , Peña Isabel , López Juan C. , Alonso Elena R. , Vaquero Vanesa 
Published: November 2018

AbstractThe simplest non‐proteinogenic amino acid α‐aminoisobutyric acid (Aib), an analogue of glycine and alanine, has been vaporized by laser ablation and probed by high‐resolution Fourier transform microwave spectroscopic techniques. Comparison of the experimental rotational and 14N nuclear quadrupole constants with that predicted ab initio has allowed the identification of three conformers of Aib exhibiting three types of hydrogen‐bond interactions I (NH⋅⋅⋅O=C, cis‐COOH), II (OH⋅⋅⋅N, trans‐COOH), and III (N−H⋅⋅⋅O−H, cis‐COOH) within the amino acid backbone. The observation of conformer III, not detected previously for related proteinogenic amino acids with a nonpolar side chain in a supersonic expansion, indicates that the presence of the methyl groups should restrict the conformational relaxation from conformer Aib‐III to Aib‐I. For conformer Aib‐II, the rotational spectra of the 13C isotopomers reveal a tunneling motion arising from the two equivalent methyl groups in the molecule. The observation of a single spectrum at the midpoint between those predicted for the two 13C of the methyl groups has been explained by considering a double‐minimum potential function with a low‐energy interconversion barrier for a large amplitude internal motion. This singular fact has been corroborated by the anomalous centrifugal distortion effects determined in conformer Aib‐II.
Back Cover: Electrochemical Sensor Based on AgNPs‐NNH Nanocomposites for Hydrogen Peroxide Detection by Zero Current Potentiometry (Chin. J. Chem. 12/2018)
Authors: Fu Yanyi , Hao Huan , Liu Xiaoli , Zheng Jianbin 
Published: November 2018

The back cover picture shows a zero current potential technique for electrochemical sensing of hydrogen peroxide based on silver‐nickel nitrate hydroxide (AgNPs‐NNH). By using the AgNPs‐NNH nanocomposites, a very low detection limit of 0.3 nmol L−1 for hydrogen peroxide detection was achieved. The zero current potential technique holds great promise for the construction of novel electrochemical sensors and the application to various targets assay. More details are discussed in the article by Zheng et al. on page 1174–1178.
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Loss of ATRX/DAXX expression and alternative lengthening of telomeres in uterine leiomyomas
Authors: Ahvenainen Terhi V. , Mäkinen Netta M. , von Nandelstadh Pernilla , Vahteristo Maija E. A. , Pasanen Annukka M. , Bützow Ralf C. , Vahteristo Pia M. 
Published: November 2018

BackgroundUterine leiomyomas (ULs) are the most common gynecologic tumors and affect 3 of every 4 women by the age of 50 years. The majority of ULs are classified as conventional tumors, whereas 10% represent various histopathological subtypes with features that mimic malignancy. These subtypes include cellular and mitotically active ULs and ULs with bizarre nuclei. Uterine leiomyosarcoma (ULMS), the malignant counterpart of UL, is an aggressive cancer with poor overall survival. The early diagnosis and preoperative differentiation of ULMS from UL are often challenging because their symptoms and morphology resemble one another. Recent studies have shown frequent loss of alpha‐thalassemia/mental retardation syndrome X‐linked (ATRX) or death domain–associated protein (DAXX) expression in ULMS, and this is often associated with an alternative lengthening of telomeres (ALT) phenotype.MethodsTo investigate ATRX and DAXX expression and the presence of ALT in UL subtypes, immunohistochemical and telomere‐specific fluorescence in situ hybridization analyses were performed. The study material consisted of 142 formalin‐fixed, paraffin‐embedded tissue samples representing various UL subtypes and 64 conventional ULs.ResultsA loss of ATRX or DAXX and/or ALT was detected in 6.3% of the histopathological UL subtype samples (9 of 142). Two patients whose ULs showed either ATRX loss or ALT were later diagnosed with a pulmonary smooth muscle tumor. Pulmonary tumors displayed molecular alterations found in the corresponding uterine tumors, which indicated metastasis to the lungs. All conventional ULs displayed normal ATRX, DAXX, and telomeres.ConclusionsThese results highlight the differences between conventional and histopathologically atypical ULs and indicate that some UL subtype tumors may harbor long‐term malignant potential.