bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pentachloropseudilin Impairs Angiogenesis by Disrupting the Actin Cytoskeleton, Integrin Trafficking and the Cell Cycle
Authors: Cota Teixeira Samuel , Silva Lopes Daiana , Santos da Silva Marcelo , Cordero da Luz Felipe Andrés , Cirilo Gimenes Sarah Natalie , Borges Bruna Cristina , Alves da Silva Aline , Alves Martins Flávia , Alves dos Santos Marlus , Teixeira Thaise Lara , Oliveira Ricardo A. , de Melo Rodrigues Ávila Veridiana , Barbosa Silva Marcelo José , Elias Maria Carolina , Martin René , Vieira da Silva Claudio , Knölker Hans‐Joachim 
Published: April 2019

AbstractClass 1 myosins (Myo1s) were the first unconventional myosins identified and humans have eight known Myo1 isoforms. The Myo1 family is involved in the regulation of gene expression, cytoskeletal rearrangements, delivery of proteins to the cell surface, cell migration and spreading. Thus, the important role of Myo1s in different biological processes is evident. In this study, we have investigated the effects of pentachloropseudilin (PClP), a reversible and allosteric potent inhibitor of Myo1s, on angiogenesis. We demonstrated that treatment of cells with PClP promoted a decrease in the number of vessels. The observed inhibition of angiogenesis is likely to be related to the inhibition of cell proliferation, migration and adhesion, as well as to alteration of the actin cytoskeleton pattern, as shown on a PClP‐treated HUVEC cell line. Moreover, we also demonstrated that PClP treatment partially prevented the delivery of integrins to the plasma membrane. Finally, we showed that PClP caused DNA strand breaks, which are probably repaired during the cell cycle arrest in the G1 phase. Taken together, our results suggest that Myo1s participate directly in the angiogenesis process.
Costs of postoperative delirium with transcatheter aortic valve replacement: Improved yet still present
Authors: Ashley Kellan E. , Hillegass William B. 
Published: April 2019

Key Points

Transcatheter aortic valve replacement (TAVR) is associated with a lower risk of postoperative delirium (PD) than surgical aortic valve replacement (SAVR) in patients aged ≥80, based on billing codes.
Postoperative delirium remains a frequent problem after both SAVR and TAVR in clinical series and is costly.
Improved pre‐procedural prediction of PD risk would improve targeting of clinical care and allow testing of preventative and management strategies.
PK Papyrus covered stent: Device description and early experience for the treatment of coronary artery perforations
Authors: Kandzari David E. , Birkemeyer Ralf 
Published: April 2019

AbstractBackgroundCoronary artery perforation during percutaneous revascularization is associated with considerable morbidity and mortality. The PK Papyrus covered stent provides a physical barrier to seal perforated arteries and prevent associated complications including death.MethodsIn a survey of patients treated for coronary artery perforation with the PK Papyrus stent in 16 countries, procedural and in‐hospital outcomes were ascertained. Procedural variables included device delivery, sealing of the perforation, and complications related to the covered stent.ResultsAmong 80 patients with coronary perforation, Ellis classification was characterized as grade III or III‐cavity spilling in 50.0% and 17.5% of events, respectively. The mean (±SD) number of stents attempted for use per patient was 1.25 ± 0.61. The PK Papyrus stent was successfully delivered to the site of perforation in 76 patients (95.0%), and successful sealing was reported in 73 patients (91.3%). Pericardiocentesis was performed in seven patients (8.8%), and in‐hospital death occurred in eight patients (10.0%). Among patient deaths, Ellis grade III perforations were reported in all instances (data not reported in one patient), and two cases were associated with unsuccessful sealing of the perforation site.ConclusionsThe PK Papyrus covered stent is designed to overcome limitations of existing therapies and to facilitate device delivery and effectively treat coronary artery perforations. Initial experience demonstrates favorably high rates of successful delivery to and sealing of the perforation site. Despite treatment, in‐hospital mortality remains high for patients experiencing Ellis grade III coronary perforations.
Spindle Epithelial Tumor of Thymus‐like Differentiation (SETTLE) in a 3‐year‐old African girl
Authors: Ogundoyin Olakayode O. , Ogun Gabriel , Oluwasola Abideen , Junaid Tamaldeen A. 
Published: April 2019

Key Clinical MessageSpindle epithelial tumor with thymus‐like differentiation (SETTLE) is a rare tumor of the thyroid gland occurring in children and young adults. This report presents SETTLE as a tumor that can also affect young children (under fives). Although majority of the reports were in Caucasians, the tumor can affect all races.
Decarboxylative Fluorination of 2‐Pyridylacetates
Authors: Kawanishi Ryouta , Phongphane Lacksany , Iwasa Seiji , Shibatomi Kazutaka 
Published: April 2019

AbstractSyntheses of substituted pyridines and fluorinated compounds, which are often pharmaceutical targets, are important objectives in organic chemistry. Herein, we found that decarboxylative fluorination of lithium 2‐pyridylacetates occur under catalyst‐free conditions. The phenomenon can be applied to one‐pot transformation of substituted methyl 2‐pyridylacetate to 2‐(fluoroalkyl)pyridine by decarboxylative fluorination of the intermediate lithium 2‐pyridylacetate. This method was also applied to the syntheses of 2‐(difluoroalkyl)pyridines.
Construction of a Shape‐Diverse Fragment Set: Design, Synthesis and Screen against Aurora‐A Kinase
Authors: Zhang Rong , McIntyre Patrick J. , Collins Patrick M. , Foley Daniel J. , Arter Christopher , von Delft Frank , Bayliss Richard , Warriner Stuart , Nelson Adam 
Published: April 2019

AbstractHistorically, chemists have explored chemical space in a highly uneven and unsystematic manner. As an example, the shape diversity of existing fragment sets does not generally reflect that of all theoretically possible fragments. To assess experimentally the added value of increased three dimensionality, a shape‐diverse fragment set was designed and collated. The set was assembled by both using commercially available fragments and harnessing unified synthetic approaches to sp3‐rich molecular scaffolds. The resulting set of 80 fragments was highly three‐dimensional, and its shape diversity was significantly enriched by twenty synthesised fragments. The fragment set was screened by high‐throughput protein crystallography against Aurora‐A kinase, revealing four hits that targeted the binding site of allosteric regulators. In the longer term, it is envisaged that the fragment set could be screened against a range of functionally diverse proteins, allowing the added value of more shape‐diverse screening collections to be more fully assessed.
Luminescent Molecular Octopuses with a Polyhedral Oligomeric Silsesquioxane (POSS) Core and Iridium(III) Polypyridine Arms: Synthesis, Aggregation Induced Emission, Cellular Uptake, and Bioimaging Studies
Authors: Zhu Jing‐Hui , Tang Ben Zhong , Lo Kenneth Kam‐Wing 
Published: April 2019

AbstractA new class of luminescent molecular hybrids in which eight cyclometalated iridium(III) polypyridine complexes are grafted onto a polyhedral oligomeric silsesquioxane (POSS) unit [POSS‐{Ir(N^C)2(py‐im)}8](PF6)8 [py‐im=pyridine imine; HN^C=N‐phenylpyrazole (Hppz) (1 a), 2‐phenylpyridine (Hppy) (2 a), 2‐phenylquinoline (Hpq) (3 a)] were synthesized and characterized. On photoexcitation, the complexes showed intense and long‐lived orange‐red to red emission in fluid solutions at room temperature and in low‐temperature glasses. The photophysical properties including aggregation‐induced emission and biological properties of these complexes were studied and compared with those of their POSS‐free counterparts [Ir(N^C)2(py‐im)](PF6) [HN^C=Hppz (1 b), Hppy (2 b), Hpq (3 b)]. The (photo)cytotoxicity of the complexes was examined by the MTT assay, and their cellular uptake and intracellular localization were investigated by inductively coupled plasma‐mass spectrometry and laser‐scanning confocal microscopy.
Asymmetric Electrochemical Catalysis
Authors: Lin Qifeng , Li Longji , Luo Sanzhong 
Published: April 2019

AbstractAsymmetric electrochemical catalysis, an emerging frontline in asymmetric catalysis and electro‐organic synthesis, is summarized. Representative works are classified, with respect to the external chiral resources, including chiral media, chiral mediator, chiral catalyst, and chiral electrode. This concept article is expected to provide readers with the general concepts and perspectives of each chiral electrochemical catalysis mode, and to indicate the potential and future development of asymmetric electrochemical catalysis.
Structure Elucidation of a Melam–Melem Adduct by a Combined Approach of Synchrotron X‐ray Diffraction and DFT Calculations
Authors: Kessler Fabian K. , Burow Asbjörn M. , Savasci Gökcen , Rosenthal Tobias , Schultz Peter , Wirnhier Eva , Oeckler Oliver , Ochsenfeld Christian , Schnick Wolfgang 
Published: April 2019

AbstractMelam‐melem (1:1), an adduct compound that can be obtained from dicyandiamide in autoclave reactions at 450 °C and elevated ammonia pressure, had previously been described based on mass spectrometry and NMR spectroscopy, but only incompletely characterized. The crystal structure of this compound has now been elucidated by means of synchrotron microfocus diffraction and subsequent quantum‐chemical structure optimization applying DFT methods. The structure was refined in triclinic space group P
based on X‐ray data. Cell parameters of a=4.56(2), b=19.34(8), c=21.58(11) Å, α=73.34(11)°, β=89.1(2)°, and γ=88.4(2)° were experimentally obtained. The resulting cell volumes agree with the DFT optimized value to within 7 %. Molecular units in the structure form stacks that are interconnected by a vast array of hydrogen bridge interactions. Remarkably large melam dihedral angles of 48.4° were found that allow melam to interact with melem molecules from different stack layers, thus forming a 3D network. π‐stacking interactions appear to play no major role in this structure.
Recent Progress on the Design, Characterization, and Application of Superalkalis
Authors: Sun Wei‐Ming , Wu Di 
Published: April 2019

AbstractSuperalkalis are clusters or molecules featuring lower ionization energies (IEs) than that of cesium atoms, and thus exhibit excellent reducing properties. Such special species have great potential to be used in the synthesis of unusual charge‐transfer salts and cluster‐assembled nanomaterials with tailored properties, in the reduction of carbon dioxide, or as hydrogen storage materials and noble‐gas‐trapping agents, etc. In this regard, ongoing efforts have been devoted to designing and characterizing superalkalis of new types. The recent progress on the study of superalkalis in terms of theoretical design, characterization, and potential application is summarized in this minireview. We hope this review will not only provide a broad overview of this research field, but also highlight the prospect of further extending the experimental synthesis and practical application of superalkalis.
A Matter of Fidelity: Self‐Sorting Behavior of Di‐Gold Metallotweezers
Authors: Ibáñez Susana , Peris Eduardo 
Published: April 2019

AbstractCation‐induced high selective self‐sorting is observed for reactions involving a series of di‐gold metallotweezers. The variation of the nature of the arms of the tweezers (benzo‐imidazolylidene or pyrene‐imidazolylidene), or the rigid bis‐alkynyl linker (anthracenyl‐bis‐alkynyl or xanthenyl‐bis‐alkynyl), induces different type of self‐sorting events upon addition of a metal cation (Cu+, Tl+, or Ag+). Combining two tweezers with the same arms and different linkers produces narcissistic self‐sorting. The combination of tweezers with the same linker and different ligands at the arms produces social self‐sorting.
Consumers' perception on corporate social responsibility: Evidence from Vietnam
Authors: Huang Yung‐Fu , Do Manh‐Hoang , Kumar Vimal 
Published: April 2019

AbstractThe purpose of this research focuses on examining the consumers' perception towards corporate social responsibility (CSR) in a developing country via the case of Vietnam. This study was conducted by face‐to‐face interview, and the questionnaire was mailed directly to consumers who are living in the urban and rural areas in Vietnam. The findings of this research are to clarify consumers' perception of CSR issues in Vietnam based on four dimensions of the CSR definition by Carroll in 1991. Therefore, the results are useful for future researchers about CSR and consumers' perception in a developing country. Although, there have been some previous studies about consumers' perception in both developed and developing countries have been chosen. However, this study has applied Carroll's definition with other approach and compared it with other articles that aim to fill this knowledge gap in Vietnam because Vietnam can represent other developing countries nowadays; besides, those results allow enterprises to understand Vietnamese consumers' perception better.
Differences in the literacy skills of Danish dyslexic students in two types of higher education programmes
Authors: Bønnerup Katrine H. , Pedersen Anne Leth , Weed Ethan , Parrila Rauno 
Published: April 2019

Previous research has treated high‐functioning dyslexic students as a homogeneous group. This study explores the clinical observation that dyslexic students attending university programmes differ from dyslexic students attending tertiary education professional programmes in some aspects of their literacy skills. Four groups, dyslexic university students (n = 32), dyslexic students attending professional programmes (n = 32), control university students (n = 31), and control students from professional programmes (n = 30), were assessed on measures of pseudoword reading, phonological choice, vocabulary, reading and spelling of morphologically complex single words, and reading aloud from a syntactically complex text. The results showed that the two dyslexic groups were comparable only on the phonological tasks, the dyslexic university students outperforming the professional programme students in all reading and spelling measures. Controlling vocabulary and number of semesters studied, the difference was no longer significant. Nevertheless, the analyses indicate that phonological deficits underlie the performance of professional programme students with dyslexia across a wide range of tasks, whereas university students with dyslexia may be able to limit the impact of phonological deficits to some extent by relying on some alternative cognitive attributes. Reading experience, orthographic learning, and working memory efficiency are discussed as possible explanations for this pattern of results.
Contagious fear: Escape behavior increases with flock size in European gregarious birds
Authors: Morelli Federico , Benedetti Yanina , Díaz Mario , Grim Tomas , Ibáñez‐Álamo Juan Diego , Jokimäki Jukka , Kaisanlahti‐Jokimäki Marja‐Liisa , Tätte Kunter , Markó Gábor , Jiang Yiting , Tryjanowski Piotr , Møller Anders Pape 
Published: April 2019

AbstractFlight initiation distance (FID), the distance at which individuals take flight when approached by a potential (human) predator, is a tool for understanding predator–prey interactions. Among the factors affecting FID, tests of effects of group size (i.e., number of potential prey) on FID have yielded contrasting results. Group size or flock size could either affect FID negatively (i.e., the dilution effect caused by the presence of many individuals) or positively (i.e., increased vigilance due to more eyes scanning for predators). These effects may be associated with gregarious species, because such species should be better adapted to exploiting information from other individuals in the group than nongregarious species. Sociality may explain why earlier findings on group size versus FID have yielded different conclusions. Here, we analyzed how flock size affected bird FID in eight European countries. A phylogenetic generalized least square regression model was used to investigate changes in escape behavior of bird species in relation to number of individuals in the flock, starting distance, diet, latitude, and type of habitat. Flock size of different bird species influenced how species responded to perceived threats. We found that gregarious birds reacted to a potential predator earlier (longer FID) when aggregated in large flocks. These results support a higher vigilance arising from many eyes scanning in birds, suggesting that sociality may be a key factor in the evolution of antipredator behavior both in urban and rural areas. Finally, future studies comparing FID must pay explicit attention to the number of individuals in flocks of gregarious species.
Wolbachia pipientis occurs in Aedes aegypti populations in New Mexico and Florida, USA
Authors: Kulkarni Aditi , Yu Wanqin , Jiang Jinjin , Sanchez Concepcion , Karna Ajit K. , Martinez Kalli J. L. , Hanley Kathryn A. , Buenemann Michaela , Hansen Immo A. , Xue Rui‐de , Ettestad Paul , Melman Sandra , Duguma Dagne , Debboun Mustapha , Xu Jiannong 
Published: April 2019

AbstractThe mosquitoes Aedes aegypti (L.) and Ae. albopictus Skuse are the major vectors of dengue, Zika, yellow fever, and chikungunya viruses worldwide. Wolbachia, an endosymbiotic bacterium present in many insects, is being utilized in novel vector control strategies to manipulate mosquito life history and vector competence to curb virus transmission. Earlier studies have found that Wolbachia is commonly detected in Ae. albopictus but rarely detected in Ae. aegypti. In this study, we used a two‐step PCR assay to detect Wolbachia in wild‐collected samples of Ae. aegypti. The PCR products were sequenced to validate amplicons and identify Wolbachia strains. A loop‐mediated isothermal amplification (LAMP) assay was developed and used for detecting Wolbachia in selected mosquito specimens as well. We found Wolbachia in 85/148 (57.4%) wild Ae. aegypti specimens from various cities in New Mexico, and in 2/46 (4.3%) from St. Augustine, Florida. Wolbachia was not detected in 94 samples of Ae. aegypti from Deer Park, Harris County, Texas. Wolbachia detected in Ae. aegypti from both New Mexico and Florida was the wAlbB strain of Wolbachia pipientis. A Wolbachia‐positive colony of Ae. aegypti was established from pupae collected in Las Cruces, New Mexico, in 2018. The infected females of this strain transmitted Wolbachia to their progeny when crossed with males of Rockefeller strain of Ae. aegypti, which does not carry Wolbachia. In contrast, none of the progeny of Las Cruces males mated to Rockefeller females were infected with Wolbachia.
The pollination system of the widely distributed mammal‐pollinated Mucuna macrocarpa (Fabaceae) in the tropics
Authors: Kobayashi Shun , Denda Tetsuo , Placksanoi Jumlong , Waengsothorn Surachit , Aryuthaka Chittima , Panha Somsak , Izawa Masako 
Published: April 2019

AbstractAlthough the pollinators of some plant species differ across regions, only a few mammal‐pollinated plant species have regional pollinator differences in Asia. Mucuna macrocarpa (Fabaceae) is pollinated by squirrels, flying foxes, and macaques in subtropical and temperate islands. In this study, the pollination system of M. macrocarpa was identified in tropical Asia, where the genus originally diversified. This species requires “explosive opening” of the flower, where the wing petals must be pressed down and the banner petal pushed upward to fully expose the stamens and pistil. A bagging experiment showed that fruits did not develop in inflorescences (n = 66) with unopened flowers, whereas fruits developed in 68.7% of inflorescences (n = 131) with opened flowers. This indicated that the explosive opening is needed for the species to reproduce. Four potential pollinator mammals were identified by a video camera‐trap survey, and 78.3% and 60.1% of monitored inflorescences (n = 138) were opened by gray‐bellied squirrels (Callosciurus caniceps) and Finlayson's squirrels (C. finlaysonii), respectively, even though more than 10 mammal species visited flowers. Nectar was surrounded by the calyx, and the volume and sugar concentration of secreted nectar did not change during the day. This nectar secretion pattern is similar to those reported by previous studies in other regions. These results showed that the main pollinators of M. macrocarpa in the tropics are squirrels. However, the species' nectar secretion pattern is not specifically adapted to this particular pollinator. Pollinators of M. macrocarpa differ throughout the distribution range based on the fauna present, but there might not have been no distinctive changes in the attractive traits that accompanied these changes in pollinators.
Temporal and spatial changes in macrozoobenthos diversity in Poyang Lake Basin, China
Authors: Li Ke , Liu Xiongjun , Zhou Yu , Xu Yang , Lv Qian , Ouyang Shan , Wu Xiaoping 
Published: April 2019

AbstractPoyang Lake plays a significant role in maintaining and replenishing the macrozoobenthos biodiversity in the middle Yangtze River. However, due to human activities and natural factors, the habitat of Poyang Lake has been seriously degraded, resulting in a decline in macrozoobenthos biodiversity. Here, we analyzed the effect of human activity and environmental elements change on the diversity of macrozoobenthos based on a systematic investigation of Poyang Lake Basin in 2016–2017. The current species richness, density, and biomass of macrozoobenthos were lower than those in the historical period. At the same time, the community structure of the macrozoobenthos assemblage exhibits significant temporal and spatial differences. In addition, the spatial turnover component was the main contribution to beta diversity, which indicated that a number of protected areas would be necessary to conserve the biodiversity of macrozoobenthos. Water depth, dissolved oxygen, water velocity, and chlorophyll‐a were significantly correlated with macrozoobenthos distributions and assemblage structure based on RDA. These results indicated that human activities have seriously destroyed the macrozoobenthos habitat and led to the decline in macrozoobenthos diversity. Therefore, habitat restoration and the conservation of macrozoobenthos have become urgent in Poyang Lake Basin, and an integrated management plan should be developed and effectively implemented.