bluuebunny/crossref_metadata_2025_split huggingface dataset:
Like-simile and metaphor in cooperation: from expressing similarities to expressing contrasts
Authors: Reda Ghsoon 
Published: November 2024

Abstract
Cognitive-oriented work on simile has developed out of attempts to pinpoint features distinguishing simile and metaphor. This development has had such consequences as 1) focusing on simile as an analogy-based process and 2) giving very little attention to the way simile and metaphor work together, treating them as independent rather than cooperating phenomena. Addressing these shortcomings, this study examines the ability of non-ironic like-simile to imply contrasts between the asserted source-target similarity and a thought or belief evoked by this similarity, giving rise to context-bound attitudinal and illocutionary implications. In cases of like-simile scaffolded by metaphors, the contrast-based process arises from the cooperation of the two phenomena in the sense that the scenario created by the like-simile rests on manipulating the conceptual metaphor(s) supporting the comparison. The analysis of these cases is placed in the Extended Conceptual Metaphor Theory (ECMT) – a contextual, multilevel theory of figurative language conceptualisation. The contrast-based process, drawn from the model of irony developed within the Lexical Constructional Model (LCM), is added to this theory as a mental-space level activity. Raykowski’s sensory schema (a generalized notion of accumulation intuitions) is also added above the image-schema level metaphors, presenting the manipulation of the scaffolding metaphors as based on the expression of this schema.
Despite Current Challenges: Lexicography has a bright future
Authors: Gouws Rufus H. , Tarp Sven 
Published: November 2024

Abstract
This paper responds to some of the fears regarding the future of lexicography. By referring to a number of paradigm shifts in the history of lexicography, some of the innovative endeavours currently occurring in lexicography and a number of exciting future possibilities, the paper tries to show that there is hope for a bright lexicographical future. This paper maintains the division of lexicography into two components, namely dictionography and glossography, and places special emphasis on glossography and the role of glosses. It is shown that glosses played a significant role in the early phases of lexicography and have re-emerged in the digital era where their use leads to innovative lexicographical procedures. It is argued that new challenges demand new ways of thinking about lexicography.
Oligonucleotide therapeutics for neurodegenerative diseases
Authors: Li Victor , Huang Yunlong 
Published: November 2024

Abstract
Recently there has been a surge in interest involving the application of oligonucleotides, including small interfering RNA (siRNA) and antisense oligonucleotides (ASOs), for the treatment of chronic diseases that have few available therapeutic options. This emerging class of drugs primarily operates by selectively suppressing target genes through antisense and/or RNA interference mechanisms. While various commercial medications exist for delivering oligonucleotides to the hepatic tissue, achieving effective delivery to extra hepatic tissues remains a formidable challenge. Here, we review recent advances in oligonucleotide technologies, including nanoparticle delivery, local administration, and 2′-O-hexadecyl (C16)-conjugation that work to extend the applicability of siRNAs and ASOs to nerve tissues. We discuss critical factors pivotal for the successful clinical translations of these modified or engineered oligonucleotides in the context of treating neurodegenerative diseases such as Alzheimer’s disease and amyotrophic lateral sclerosis.
Exosomal microRNA-21-5p from gastric cancer cells promotes angiogenesis by targeting LEMD3 in human endothelial cells
Authors: Zhou Tianbao , Lu Ping 
Published: November 2024

Abstract

Objectives
The effect of exosome-derived miR-21-5p from gastric cancer (GC) on angiogenesis remains unclear. This study aims to examine the angiogenic impact of GC exosome-derived miR-21-5p.

Methods
Exosomes were isolated from GC cells and co-cultured with human umbilical vein endothelial cells (HUVECs). miR-21-5p levels in HUVECs were measured by qPCR. Flow cytometry was used to assess apoptosis, and the Cell Counting Kit-8 was used to assess cell growth. Bioinformatics analysis was used to identify the miR-21-5p target genes, which were then verified by dual-luciferase gene reporter experiments. qPCR and western blotting were employed to assess the expression of genes and proteins, respectively. Functional rescue assays were conducted to verify that miR-21-5p regulates endothelial cell function by targeting the LEM domain containing 3 (LEMD3). Additionally, cell migration was assessed using a scratch assay.

Results
Co-cultivation with GC-derived exosomes improved cell survival, decreased apoptosis, and raised miR-21-5p levels in HUVECs. Increases in vascular endothelial growth factor A (VEGFA) and the TGF-β/Smad signaling pathway were seen. It was shown that miR-21-5p targets LEMD3. The biological effects of miR-21-5p were lessened when miR-21-5p was inhibited, or LEMD3 was overexpressed.

Conclusions
By targeting LEMD3, miR-21-5p in GC cell exosomes stimulates angiogenesis by triggering the TGF-β/Smad signaling cascade and upregulating VEGFA expression. This leads to increased proliferation, survival, and migration of HUVECs, underscoring the potential of targeting this pathway in cancer therapy.
Excitation functions of proton-induced nuclear reactions on titanium
Authors: Kholil Sinthia Binte , Uddin M. Shuza , Hasan M. Mehedi , Chakraborty A. Kumer , Shariff M. Asad , Voyles Andrew S. , Spahn Ingo 
Published: November 2024

Abstract
Excitation functions of the natTi(p,x)43,44m,44g,46,47,48Sc and natTi(p,x)48V reactions were measured using stacked target activation from reaction thresholds up to 44.28 MeV. A wide energy range was achieved by irradiating several stacks with proton beams of energies 16.7 MeV, 27 MeV, and 44.5 MeV. Cross-section data were obtained from 15 to 25 MeV at the Lawrence Berkeley National Laboratory (LBNL) and from 14 to 44.28 MeV and 8–17 MeV at the Forschungszentrum Jülich (FZJ). Each set of measured data agrees well with each other in the overlapping energy regions. The cross sections were also calculated theoretically using the TALYS code, and the model calculations reproduced the experimental values well. Generally, the results obtained for proton-induced reactions using the global set of parameters, as expressed in the TENDL-2021 data library, are not satisfactory. Our measurements are valuable for resolving discrepancies in the existing data and providing insights into reaction mechanisms.
Advanced techniques and innovations in peripheral nerve repair: a comprehensive review for clinical and experimental reference
Authors: Zou Yuchun , Zhang Gonghang , Yang Yuchen , Huang Hankai , Li Zongxu , Chen Xiaohang , Zheng Dali , Lu You-guang , Niu Gang 
Published: November 2024

Abstract
Peripheral nerve injury, resulting from various physical and chemical causes, has a high incidence and significant functional impact. This injury, affecting both sensory and motor functions, can severely diminish quality of life and cause mental health issues. Consequently, it is a major focus of current research. Recent advancements in peripheral nerve repair technology, including the application of new techniques and materials, have expanded the options for nerve repair methods. A comprehensive article that combines the pathological process of peripheral nerve repair with these methods is needed to advance research in this field. This review aims to provide a comprehensive overview of various techniques for repairing peripheral nerve injuries. Beginning with the histopathology of nerve injury, it evaluates these techniques in detail to offer clinical guidance. This review summarizes the advantages and disadvantages of various peripheral nerve repair methods, including photobiological modulation therapy, suture repair, nerve graft repair, vein graft catheter repair, muscle graft repair, laser welding repair, nerve catheter repair, nerve sliding repair technology, growth factor-assisted repair, stem cell therapy, and exosome therapy. Additionally, it explores future directions in the treatment of peripheral nerve injuries, providing valuable references for experimental research and clinical treatment.
Review of structural neuroimaging and genetic findings in autism spectrum disorder – a clinical perspective
Authors: Budisteanu Magdalena , Papuc Sorina Mihaela , Erbescu Alina , Glangher Adelina , Andrei Emanuela , Rad Florina , Hinescu Mihail Eugen , Arghir Aurora 
Published: November 2024

Abstract
Autism spectrum disorders (ASDs) are neurodevelopmental conditions characterized by deficits in social relationships and communication and restrictive, repetitive behaviors and interests. ASDs form a heterogeneous group from a clinical and genetic perspective. Currently, ASDs diagnosis is based on the clinical observation of the individual’s behavior. The subjective nature of behavioral diagnoses, in the context of ASDs heterogeneity, contributes to significant variation in the age at ASD diagnosis. Early detection has been proved to be critical in ASDs, as early start of appropriate therapeutic interventions greatly improve the outcome for some children. Structural magnetic resonance imaging (MRI) is widely used in the diagnostic work-up of neurodevelopmental conditions, including ASDs, mostly for brain malformations detection. Recently, the focus of brain imaging shifted towards quantitative MRI parameters, aiming to identify subtle changes that may establish early detection biomarkers. ASDs have a strong genetic component; deletions and duplications of several genomic loci have been strongly associated with ASDs risk. Consequently, a multitude of neuroimaging and genetic findings emerged in ASDs in the recent years. The association of gross or subtle changes in brain morphometry and volumes with different genetic defects has the potential to bring new insights regarding normal development and pathomechanisms of various disorders affecting the brain. Still, the clinical implications of these discoveries and the impact of genetic abnormalities on brain structure and function are unclear. Here we review the literature on brain imaging correlated with the most prevalent genomic imbalances in ASD, and discuss the potential clinical impact.
Exploring the Relationship Between ESG Performance and Dividend Policy in MENAT Region: The Role of Audit Quality
Authors: Abdel Hameed Yasmin Mamdouh 
Published: November 2024

Abstract
Exploring the significance of ESG performance is especially crucial in the Middle East, North Africa, and Turkey (MENAT) area, where economic and cultural environments differ. The study aims to empirically assess the relationship between firms’ dividend policy and ESG performance in MENAT, along with the moderating effect of audit quality. The research is novel in exploring this link in the MENAT region. The study uses dividend yield (DY) as the dependent variable and yearly ESG combined score from the Eikon Refinitiv database, which range from 0 to 100 as the primary independent variable, with control variables as retained earnings, profitability, firm size, and financial leverage. The results indicate a significant negative relationship between ESG scores and dividend yields, suggesting a trade-off between prioritizing ESG factors and short-term returns. The moderating effect of audit quality on the ESG-dividend policy connection is insignificant. Additionally, retained earnings and corporate size have positive effects on dividend policy, while financial leverage has a negative impact. Profitability shows an insignificant effect on dividend yield.
A genealogy of poetry
Authors: Young Jake 
Published: November 2024

Abstract
Poetry does not have a history; it has many histories. By tracing the history of poetry in the West, in conjunction with genre studies and research on concept formation, it is evident that the genre “poetry” is contingent on the various rhetorical situations of its production. Such an approach reveals that the concept “poetry,” like all concepts, is always in flux. Yet, despite the fact that “poetry” means different things to different people in different times and places, studies of oral poetry have yielded insights into traits that might be considered universal to poetry, such as its performativity and categorization as ritual language. Other common aspects include the use of parallelism, analogy and metaphor, musicality, and how poems function as metapragmatic symbols that reflect the values of their cultural production. This functionalist approach to poetry reveals that the evolution of poetry is at once historically contingent and culturally universal, and recognizes that poetry’s multiplicity and continual becoming operate with the primary goals of generating and sharing culturally relative meaning.
A semiotic lifeworld. Semiotics and phenomenology: Peirce, Husserl, Heidegger, Deleuze, and Merleau-Ponty
Authors: Paolucci Claudio 
Published: November 2024

Abstract
If we think of cognition and experience from the enactivist idea of a structural coupling between organism and environment, we see that this environment is first and foremost a semiotic environment, crowded with objects, norms, habits, institutions, and artefacts that shape our minds and represent the background of our perception of the world. This semiotic environment, which goes far beyond the opposition between nature and culture, (See Paolucci 2021. Cognitive semiotics: Integrating signs, minds, meaning, and cognition. Berlin: Springer: ch. 1.) is a semiotic lifeworld that is important to compare with the classic idea of lifeworld coming from phenomenology. In this paper, (i) we will first start with a comparison of the semiotic Lebenswelt and the phenomenological Lebenswelt; (ii) we will follow the construction of the semiotic lifeworld coming from Peirce’s Anti-Cartesian essays; (iii) we will make a deep comparison between the phenomenology coming from Peirce (phaneroscopy) and the phenomenology coming from Husserl, Heidegger, and Merleau-Ponty; (iv) we will show how these very same principles also ground structuralism; (v) we will show how this new semiotic lifeworld grounded on phaneroscopy is neither pre-logical nor pre-categorial. Rather, it is founded on the primacy of “telling” over “showing,” and on the primacy of discourse over perception.
A footless stroll through Italian stress
Authors: Faust Noam , Ulfsbjorninn Shanti 
Published: November 2024

Abstract
Despite the fact that Italian has been studied intensely for many years, the intricate relationship between its syllable structure and its metrical facts (weight and stress assignment) still poses a very significant formal challenge to previously published theoretical accounts. In this paper, we provide a novel account of Italian stress within the framework of Strict CV Metrics. We show that this approach most accurately captures the empirical data of the language, while providing a formally simple analysis which does not require feet, binary or ternary. The analysis is computationally simple and derives the ‘three syllable’ window effect without arbitrarily stipulating the foot-size of the language or overgenerating forms.
Accuracy of Screening Tests for the Diagnosis of Urinary Tract Infections in Young Children
Authors: Shaikh Nader , Campbell Elizabeth A. , Curry Calise , Mickles Caitlin , Cole Elisabeth B. , Liu Hui , Lee Matthew C. , Conway Isabella O. , Mueller Grace D. , Gibeau Asumi , Brady Patrick W. , Rasmussen Jayne , Kohlhepp Mark , Qureini Heba , Moxey-Mims Marva , Williams Whitney , Davis-Rodriguez Stephanie 
Published: November 2024

BACKGROUND
The objective of this study was to compare the accuracy of available tests for pyuria, including newer automated tests, and to examine the implications of requiring them for the diagnosis of urinary tract infections (UTIs).

METHODS
We included children between 1 and 36 months of age undergoing bladder catheterization for suspected UTIs who presented to 1 of 3 pediatric centers. Using a positive urine culture result as the reference standard, we compared the sensitivity of 5 modalities for assessing pyuria at the cutoffs most often used clinically for detecting children with a positive culture result: leukocyte esterase on a dipstick, white blood cell (WBC) count on manual microscopy with and without using a hemocytometer, automated WBC enumeration using flow cytometry, and automated WBC enumeration using digital imaging with particle recognition.

RESULTS
A total of 4188 children were included. Among febrile children, the sensitivity of the 2 most widely available modalities, the leukocyte esterase test and WBC enumeration using digital imaging, had sensitivity values of 84% (95% confidence interval, 0.80–0.87) and 75% (95% confidence interval, 0.66–0.83), respectively.

CONCLUSIONS
Our findings suggest that for febrile children &lt;36 months of age undergoing bladder catheterization for suspected UTI, pyuria will be absent in ∼20% of children who are eventually shown to have pure growth of a pathogen on a culture. This raises questions about the appropriateness of requiring pyuria for the diagnosis of UTIs.
Industrial Control as a Service
Authors: Vogt Lucas , Honold Fabian , Schmid Tobias , Punzenberger Lukas , Greising Samuel , Waltl Josef , Beckhoff Laurids , Auer Marcel , Jilg Michael , Maurer Frank , Barth Mike , Urbas Leon , Blumer Wolfgang 
Published: November 2024

Industrial Control as a Service (ICaaS) hat das Potenzial, die IT- und die OT-Welt näher zusammenzubringen. Es verspricht eine kürzere Time-to-Market, weniger Komplexität für Anlagenbesitzer/-betreiber sowie die einfache Integration fortschrittlicher Technologien wie KI. Um diese Behauptungen zu überprüfen, werden in diesem Artikel mehrere Proof-of-Concept-Anwendungsfälle für verschiedene ICaaS-Aspekte vorgestellt und diskutiert. Darüber hinaus werden Möglichkeiten zur Weiterentwicklung des Konzepts skizziert.
The analysis of comparison performed between the standard deep breathing approach and a strategy for denitrogenating patients prior to inducing general anesthesia
Authors: Mali Sajan , Dahal Tshetiz 
Published: November 2024

Most anesthesia professionals view denitrogenating as a crucial patient safety procedure that should be carried out before administering general anesthesia and creating a secure airway. According to studies, passive spontaneous mask ventilation for three to five minutes is inferior to four deep breaths over thirty seconds (the "four-breath technique") or eight deep breaths over sixty seconds (the "eight-breath technique"). Nevertheless, there aren't any published randomized studies assessing techniques to enhance deep breathing quality in a typical clinical situation during denitrogenation. This study aims to evaluate the effectiveness of a typical coaching technique with a biofeedback strategy to improve deep breathing volumes during denitrogenation. Two groups participated in this hypothetical experimental study: the Control group (N = 11) and the Investigational group (N = 11). Four conventional deep breaths (DBs) were used to prenitrogenate both groups at the beginning. Four more DBs were completed by Control individuals utilizing the conventional coaching method. On the other hand, the patients in the experimental group received increasing DB objectives in real time using a biofeedback technique, with four breaths after each of the first four DBs. When comparing the volume of DBs 5 to 8 (p=0.005) between the Investigational group and the controls, there was a statistically significant increase. DB 5 to 8 in the experimental subjects more closely approximated the projected VC when the volume of each DB was compared to the participants' predicted VC (p=0.002). In summary, when employing a breath-to-breath biofeedback technique instead of a conventional DB coaching technique, DB volumes are noticeably higher.
No association between rs6295 of and risk of migraine: Evidence from meta-analysis
Authors: Kumar Parvinder , Sudershan Amrit , Sheikh Bashir Ahmad , Malik Showkat Ahmad , Kumar Hardeep 
Published: November 2024

Migraine is considered a complex disorder with polygenic inheritance and is associated with a variant i.e., rs6295 has been hypothesized to be involved in determining the disease susceptibility. Therefore, in the present study we aimed to find the risk between the rs6295 and migraine susceptibility using a meta-analysis approach. The present study utilizes the PRISMA guideline to review existing literature to perform pooled analysis, and also includes quality assessment, association analysis, publication, and heterogeneity analysis using the NOS tool, OR with 95% CI, tests of Begg's with Egger's test, and χ2 based on Cochran's Q Test with I tests respectively. In the present study we didn’t observe any statistical association between the rs6295 and risk of migraine (allele: 1.01 [0.83-1.22], p-value=0.92). Further sub-grouping based on the clinical sub-type, no association was observed in either group i.e., MA (allele: 1.02 [0.73-1.40], p-value=0.90) and MWA (allele: 1.03 [0.75-1.41], p-value0.83). In the present analysis after critical analysis, it was observed that rs6295 didn’t pose any significant risk to the disease susceptibility.
Spontaneous intracerebral haemorrhage in young: Can we manage in a better way?
Authors: Chakraborty Debabrata 
Published: November 2024

Intracerebral haemorrhage (ICH), a dynamic phenomenon with unpredictable course is associated with almost 50% mortality. It is sharply rising amongst the young population. The surgical intervention in ICH only when the patient deteriorates on conservative management should be given a second thought. This is because young patients with less atrophic brains suffer from a sudden rise in intracranial pressure resulting in rapid deterioration giving less time to intervene especially in odd hours. So, with the advent of new surgical techniques, it may be wiser to administer them within 24 hours of ictus rather than wait for a sudden deterioration.