bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transhepatic-intrahepatic branches of the portal vein catheterization for ex vivo liver resection and autotransplantation
Authors: Kong Junjie , Shen Shu , Yang Xianwei , Wang Wentao 
Published: March 2019

Abstract

Rationale:
There has been increased use of ex vivo liver resection and autotransplantation (ERAT) for treatment of end-stage hepatic alveolar echinococcosis (HAE). Rapid perfusion of the autograft in bench resection is always required to reduce the warm ischemia time (WIT) and to protect the function of the remnant liver. Nevertheless, the severe invasion of the portal hepatis sometimes makes it impossible to find a usable inflow rapidly and the process of perfusion could be delayed.

Patient concerns:
Two patients diagnosed with end-stage HAE combined with severe portal hepatis invasion were selected to undergo ERAT at our center.

Diagnosis:
Besides the large HAE lesions, the CT imaging of patient 1 showed that part of the intra- and extrahepatic portal vein (PV) had disappeared. Patient 2 had severe invasion of both of the right and left branches of the PV.

Interventions:
We introduced a new approach for perfusing the liver in ERAT using transhepatic-intrahepatic branches of the PV catheterization. Afterward, ERAT was successfully performed.

Outcomes:
For patient 1, the WIT was 2 minutes and the cold ischemia time (CIT) was 296 minutes. For patient 2, the WIT was 2 minutes and the CIT was 374 minutes. Patient 1 suffered stenosis of the common bile duct on postoperative day 14, and patient 2 recovered uneventfully. Both of the 2 patients were discharged from the hospital with normal laboratory values on postoperative day 31 and 15, respectively. The laboratory values for both patients at recent follow-up were normal.

Lessons:
Transhepatic-intrahepatic branches of the PV catheterization is useful for decreasing WIT and facilitating the management of ERAT. It is a useful technical variant that could be used in ERAT for treating patients with severe portal hepatis invasion.
Comparison of the psychometric properties of the EQ-5D-3L and SF-6D in the general population of Chengdu city in China
Authors: Zhao Longchao , Liu Xiang , Liu Danping , He Yan , Liu Zhijun , Li Ningxiu 
Published: March 2019

Abstract
The EQ-5D-3L and SF-6D are the most commonly used economic evaluation instruments. Data comparing the psychometric properties of the instruments are scarce in the Chinese population. This study compared the psychometric properties of these measures in the Chinese general population in Chengdu.
From October to December 2012, 2186 respondents (age ≥18) were selected from urban and rural areas of Chengdu, China, via multistage stratified cluster sampling. Correlations, scatter plots and Bland-Altman plots were used to explore the relationships between the 2 measures. Ceiling and floor effects were used to analyze the score distribution. The known-groups method was used to evaluate discriminant validity.
Among 2186 respondents, 2182 completed the questionnaire, and 2178 (18–82 years old, mean 46.09 ± 17.49) met the data quality requirement. The mean scores for the EQ-5D-3LCN, EQ-5D-3LUK, and SF-6DUK were 0.95 (Std: 0.11), 0.93 (Std: 0.15), and 0.79 (Std: 0.12), respectively. The correlations between domains ranged from 0.16 to 0.51. The correlation between the EQ-5D-3LCN and SF-6DUK and between the EQ-5D-3LUK and SF-6DUK was 0.46. The scatter plots and Bland-Altman plots demonstrated poor agreement between the EQ-5D-3L and SF-6D. The floor and ceiling effects were respectively 0.05% and 74.60% for the EQ-5D-3L and 0.05% and 2.53% for the SF-6DUK. The EQ-5D-3LCN, EQ-5D-3LUK and SF-6D have good discriminant validity in different sociodemographic and health condition groups. The SF-6D has higher level of discriminant validity in moderately healthy groups in the EQ-5D-3L full-health population.
Both the EQ-5D-3L and SF-6D are valid economic evaluation instruments in the Chinese general population in Chengdu but do not seem to be interchangeable. The EQ-5D-3L has a higher ceiling effect and higher level of discriminant validity among different sociodemographic groups, and the SF-6D has a lower ceiling effect and higher level of discriminant validity in health condition groups. Users may consider the evidence in the choice of these instruments.
Discussion on operative skills in the embolization of hydrosalpinx by hysteroscopic placement of a microcoil
Authors: Cai Hua-Lei , Pan Le-Yun , Wang Shun-Fang , Tian Yu , Zheng Xiao-Zhu , Yang Yan , Li Kun 
Published: March 2019

Abstract
This study aims to discuss the operative skills of hysteroscopic tubal embolization and reduce the occurrence of complications.
Ninety-four patients were divided into group A and group B. The main surgical technique in group A: when the inner sleeve is sent to the fallopian tube and no longer accessible (but no >3 cm), remove the guide wire and put into the microcoil. But in group B, there are four major surgical techniques. First, the depth at which the guide wire enters the tube was controlled at 2 cm. Second, the inner diameter of the fallopian tube must be explored to determine the type and shape of the coils. Third, saline should be used to separate the catheter. Fourth, it is to control the release speed of the coils. The superiority of the improved operation method was confirmed by comparing the surgical failure rate, incidence of complications, and cost of surgery before and after the procedure.
The reoperation rate of group A was 10% (3/30), while that of group B was 2.68% (3/112). The ectopic microcoils rate of group A was 6.67% (2/30), while that of group B was 0.89% (1/112). The microcoil damages rate of group 23.33% (7/30), while that of group B was 8.04% (9/112). All P values were <.01, and the difference was statistically significant.
Hysteroscopic tubal embolization is currently a new surgical procedure to block the fallopian tubes and prevent the reverse flow of fluid in the fallopian tubes into the uterine cavity. After we improved surgical techniques, the surgical failure rate, complication rate, and operation cost of fallopian tube embolization were significantly lower than before the improved method was applied. The improved techniques led to a higher success rate.
Massive hemoperitoneum and upper gastrointestinal hemorrhage following liver rupture secondary to gallbladder perforation
Authors: Lan Xiang , Xiang Yuanyuan , Liu Fei , Li Bo , Wei Yonggang , Zhang Hua 
Published: March 2019

Abstract

Rationale:
Available literature states that the common reasons for non-traumatic spontaneous liver rupture are hepatocellular carcinoma, macronodular cirrhosis, hemangioma, and other tumors; gallbladder perforation is not cited as a cause.

Patient concerns:
The patient presented with sudden-onset right upper quadrant pain with tarry stool for 3 days after eating with dysphoria and increasing thirst; gradually, hemorrhagic shock developed. He had no history of trauma, no background of chronic hepatitis, and no cirrhosis.

Diagnosis:
Hemorrhage secondary to spontaneous rupture of intrahepatic cholangiocarcinoma.

Interventions:
Left hemihepatectomy, cholecystectomy, and common bile duct exploration were performed.

Outcomes:
The patient was diagnosed with massive hemoperitoneum accompanying upper gastrointestinal hemorrhage following liver rupture secondary to gallbladder perforation. The postoperative course was uneventful and the patient was discharged after 10 days of hospitalization.

Lessons:
If patients present with non-traumatic spontaneous liver rapture accompanying cholelithiasis and gallbladder hematoma, gallbladder perforation should be considered as a differential diagnosis. Misdiagnosis can lead to incorrect treatment.
Hepatitis C virus infection is a risk factor for non-Hodgkin lymphoma
Authors: Zhu Xiaofeng , Jing Li , Li Xiaoming 
Published: March 2019

Abstract
Previous studies have reached conflicting results regarding the possibility that hepatitis C virus (HCV) infection may increase the risk of non-Hodgkin lymphoma (NHL). We performed a meta-analysis to clarify the relationship between HCV infection and development of NHL. The PubMed, Web of Science, and Embase databases were searched for relevant studies estimating the association between HCV infection and NHL risk through October 31, 2017. Fixed effects or random effects models were used to calculate the pooled odds ratio (OR) and its 95% confidence interval (CI). A total of 18 studies met the inclusion criteria. We found a positive association between HCV infection and NHL (pooled OR 1.69, 95% CI 1.40–2.03, P < .05). In conclusion, our meta-analysis suggested that HCV infection was associated with increased risk of developing NHL.
Single nucleotide polymorphism of rs2596542 and the risk of hepatocellular carcinoma development
Authors: Kuang Xue-Jun , Mo Dun-Chang , Qin Yan , Ahir Bhavesh K. , Wang Jian-Jun , Peng Zhao , Deng Zu-Liang 
Published: March 2019

Abstract

Background:
Major histocompatibility complex class I-related chain A (MICA) is considered as a tumor antigen, and its expression is affected by its genetic polymorphisms. However, the relationship between rs2596542 polymorphisms in MICA promoter region and hepatocellular carcinoma (HCC) is not fully elucidated so far. This study aims to explore the relationship between single nucleotide polymorphism of rs2596542 and the risk of HCC development through meta-analysis.

Methods:
MEDLINE, Web of Science, and EMBASE databases were systematically searched to identify relevant studies. A meta-analysis was performed to examine the association between MICA rs2596542 polymorphism and susceptibility to HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.

Results:
Fourteen case–control studies involving 4,900 HCC cases and 19,519 controls were included. The MICA rs2596542C allele was significantly associated with decreased risk of HCC based on allelic contrast (OR = 0.76, 95% CI = 0.69–0.83, P
< .001), homozygote comparison (OR = 0.57, 95% CI = 0.48–0.69, P
< .001), and a recessive genetic model (OR = 0.77, 95% CI = 0.65–0.91, P
< .001), whereas patients carrying the MICA rs2596542TT genotype had significantly higher risk of HCC than those with the CT or CC genotype (TT vs CT + CC, OR = 1.57, 95% CI = 1.36–1.81, P
< .001). Subgroups analyses based on the ethnic or the source of control groups found very similar findings.

Conclusion:
The C allele in MICA rs2596542 is a protective factor for hepatocarcinogenesis, whereas the T allele is a risk factor. Further large and well-designed studies are needed to confirm this conclusion.
Comparison between video-assisted thoracoscopic lung cancer resection and robot-assisted lung cancer resection
Authors: Chai Tianci , Lin Yuhan , Shen Zhimin , Chen Sui , Zhang Zhenyang , Lin Wenwei , Zhang Peipei , Kang Mingqiang , Lin Jiangbo 
Published: March 2019

Abstract

Background:
Video-assisted thoracoscopic surgery (VATS) has developed rapidly and a variety of feasible technical methods have been formed. VATS is the main way of lung cancer resection nowadays with minor surgical incision and less bleeding. Robot-assisted thoracic surgery (RATS) is a revolution in surgical procedures and robotic pulmonary resection has been put to use by an increasing quantity of hospitals around the world. However, the widespread adoption of robot-assisted lung cancer resection is controversial. We aimed to evaluate quality metrics of these 2 different approaches of operation by this review and meta-analysis.

Methods and Analysis:
We will search Medline, Embase, Pubmed, Google Scholar, and the Cochrane Central Register of Controlled Trials for related literature published in any language before February 28, 2019. Propensity score matched comparative studies, prospective cohort studies; randomized controlled trials (RCTs) will be included. If sufficient data are available, we will perform subgroup analysis in different operative types of lung cancer resection.

Results:
The results of this study will be published in a peer-reviewed journal.

Conclusion:
To our knowledge, this will be the first time to use meta-analysis to assess quality metrics of video-assisted thoracoscopic lung cancer resection and robot-assisted lung cancer resection. The results of this study will provide more proofs for researchers, clinicians, and patients with lung cancer to choose a suitable surgical procedure. There is not enough high-quality evidence of RCTs to be included, due to the characteristics of interventions. We will try to include some non-randomized controlled trials, small sample trails. Although our team has experience in carrying out a systematic review and meta-analysis, there may be high heterogeneity and low reliability of evidence, which is the limitation of this study.
The value of 18F-FDG PET/CT in the diagnosis of different size of solitary pulmonary nodules
Authors: Tang Kun , Wang Ling , Lin Jie , Zheng XiangWu , Wu Yiwei 
Published: March 2019

Abstract
This study aimed to evaluate the diagnostic value of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for solitary pulmonary nodules (SPNs) with different diameters.
One hundred eighty two consecutive patients with SPN who underwent 18F-FDG PET/CT examination were retrospectively studied. Patients were categorized into 3 groups according to the diameter of nodules: Group A with the diameter of greater than or equal to 6 mm and less than or equal to 10 mm; Group B with diameter greater than 10 mm and less than or equal to 20 mm; Group C with diameter greater than 20 mm and less than or equal to 30 mm. The efficiency of PET/CT, PET and CT in the diagnosis of benign and malignant SPNs and different subgroup of SPNs was calculated. Receiver operating characteristic curves (ROCs) were drawn and area under the curves (AUCs) were compared between different groups.
The age, diameter, mean standardized uptake value (SUVmean) and maximum standardized uptake value (SUVmax) of benign and malignant nodules were significantly different (P < .05). For overall SPNs, the sensitivity, specificity, accuracy, PPV, and NPV of PET/CT were 98.35%, 77.05%, 91.21%, 89.47%, and 95.92%, respectively. The AUC of PET/CT was significantly larger than that of SUVmean, SUVmax, and CT (P < .05). For different size of SPNs, the AUC of PET/CT in group A was higher than that in group B and group C, but there was no significant difference with CT (P > .05). In group B, the accuracy of PET/CT in the diagnosis of SPN was significantly higher than that of CT (P < .05).

18F-FDG PET/CT demonstrated excellent performance in identifying different size of SPNs, especially for those with diameter between 11 and 20 mm, the diagnostic value of 18F-FDG PET/CT is significantly higher than other methods.
The association between socioeconomic status and prevalence of chronic kidney disease
Authors: Shen Quanquan , Jin Wei , Ji Shuiyu , Chen Xiaoying , Zhao Xiang , Behera Tapas Ranjan 
Published: March 2019

Abstract
To investigate the prevalence of chronic kidney disease (CKD) among eastern Chinese rural residents and analyze the relationship between socioeconomic conditions and CKD.
A cross-sectional survey of 1713 adults, enrolled from 4 villages in the north-central part of Zhejiang province in eastern China was conducted by collecting data on socioeconomic status, physical examination, and laboratory investigations. CKD was defined as estimated glomerular filtration rate < 60 mL/min per 1.73 m2 or urinary albumin/creatinine ratio more than 30 mg/g. The crude and adjusted prevalence of CKD was estimated and the association of socioeconomic status was analyzed by logistic regression.
A total of 1654 adults (96.53%) completed the screening, and 1627 (98.37%) of them had complete questionnaire and test information. The standardized prevalence of CKD adjusted by age and sex was 9.21% (95% confidence interval, 7.8–10.63). People with hypertension, hyperglycemia, hyperuricemia, high fasting blood glucose, and high body mass index had higher risk for CKD. Socioeconomic status was found to be partly related to CKD, especially educational level and occupational nature.
A high prevalence of CKD was observed among rural residents in north-central Zhejiang province in eastern China. Socioeconomic statuses were partly related to the prevalence of CKD.
Serum levels of insulin-like growth factor 1 are negatively associated with log transformation of thyroid-stimulating hormone in Graves’ disease patients with hyperthyroidism or subjects with euthyroidism
Authors: Tseng Fen-Yu , Chen Yen-Ting , Chi Yu-Chiao , Chen Pei-Lung , Yang Wei-Shiung 
Published: March 2019

Abstract
Insulin-like growth factor 1 (IGF-1) has a molecular structure similar to that of insulin. As an essential mediator of growth hormone, IGF-1 plays a vital role in growth of children and anabolic effects of adults. We evaluated the serum levels of IGF-1 in patients with hyperthyroidism or euthyroidism.
In this study, 30 patients each of Graves’ disease with hyperthyroidism (HY group) and euthyroid individuals (EU group) were recruited. The HY patients were treated with antithyroid regimens as clinically indicated. No medications were given to EU patients. The demographic characteristics and anthropometric and laboratory data of both groups at baseline and 6 months were compared. Associations between levels of IGF-1 and free thyroxine (fT4), thyroid-stimulating hormone (TSH), or log transformation of TSH (logTSH) were analyzed.
At baseline, the HY patients had significantly higher serum IGF-1 levels than EU patients (median [Q1, Q3]: 305.4 [257.4, 368.1] vs. 236.7 [184.6, 318.8] ng/mL, P = .007). At 6 months, the HY patients still had higher serum levels of IGF-1 than EU patients (299.5 [249.9, 397.9] vs 222.1 [190.2, 305.4] ng/mL, P = .003). At baseline, the serum levels of IGF-1 in the HY and EU patients were positively associated with fT4 (β = 29.02, P = .002) and negatively associated with TSH (β = −31.46, P = .042) and logTSH (β = −29.04, P = .007). The associations between serum levels of IGF-1 with fT4 or TSH became insignificant at 6 months. However, the serum IGF-1 levels had persistent negative associations with logTSH at 6 months (β = −26.65, P = .021). The negative associations between IGF-1 and logTSH at baseline and 6 months remained significant even after adjustment with sex and age (β = −20.22, P = .023 and β = −20.51, P = .024, respectively).
The HY patients had higher serum IGF-1 levels than EU patients. The serum IGF-1 concentrations were negatively associated with logTSH in patients with hyperthyroidism or euthyroidism.
Effect of adiponectin level and genetic variation of its receptors on diabetic retinopathy
Authors: Liao Wen-Ling , Chen Yung-Hsiang , Chen Ching-Chu , Huang Yu-Chuen , Lin Hui-Ju , Chen Yng-Tay , Ban Bo , Wu Chia-Ming , Chang Ya-Wen , Hsieh Ai-Ru , Tsai Fuu-Jen 
Published: March 2019

AbstractAdiponectin (APN) and its receptors have been reported to be associated with metabolic phenotypes. To better understand the effects of APN levels and its receptors on diabetic retinopathy (DR), we investigated the association of the plasma APN level and variations in APN-related genes with DR, individually and in combination.Patients with type 2 diabetes (T2D; N = 1604), above 20 years of age from the Taiwanese population participated in the study. Demographic information, blood pressure, and serological markers were recorded at enrollment. Genomic DNA was isolated and genotyped. The plasma APN levels were measured by enzyme-linked immunosorbent assay.T2D patients with DR (N = 632) had diabetes for a longer duration, and had higher HbA1c, and systolic and diastolic blood pressure compared to those without DR (N = 972) (P < .001, for all the parameters). Overall, 10 single nucleotide polymorphisms (SNPs) inADIPOQandCDH13susceptibility loci were associated with DR. Gene risk score (GRS) was calculated based on 10 SNPs for each subject and the cumulative effect of genes was observed. Among the subjects with plasma APN level (N = 518), natural logarithm (LN) of APN (LN [APN]; odds ratio [OR] = 1.63, 95% confidence interval [CI] = 1.19–2.25) and GRS (OR = 1.90, 95% CI = 1.11–3.26 for middle range of GRS, and OR = 2.61, 95% CI = 1.48–4.59 for high range of GRS) were independent risk factors for DR after adjustment for other parameters.In conclusion, the plasma APN level and the genetic variations in adiponectin receptors were associated with DR.
Immunocompetent patient with a brain abscess caused by Nocardia beijingensis in Latin America
Authors: Solano-Varela David M. , Barrios-Vidales Edgar M. , Plaza David F. , Riveros William M. , Guzmán Julián , Chica Claudia E. , Patarroyo Manuel A. 
Published: March 2019

Abstract

Rationale:

Nocardia species are not commonly referred as primary infectious entities but rather as opportunistic pathogens. Infectious cases of Nocardia spp. in immunocompetent individuals are rare.

Patient concerns:
An immunocompetent 58-year-old patient presented with recurrent headaches.

Diagnosis:
A brain abscess was found and surgically drained. Matrix-assisted laser desorption ionization–time-of-flight mass spectrometry and heat shock protein 65/16S-23S rRNA gene intergenic spacer genotyping from the sample revealed the etiological agent as Nocardia beijingensis.

Interventions:
Meropenem/amikacin/Trimethoprim-sulfamethoxazole were administered.

Outcomes:
The infection persisted leading to the patient's death.

Lessons:
Here we present the first case of N. beijingensis infection of the central nervous system in an immunocompetent patient from Latin America. Further inquiry is needed to establish whether this species is more virulent than other Nocardia isolates.
A cross-sectional study on the correlation between physical activity levels and health-related quality of life in community-dwelling middle-aged and older adults
Authors: Abdelbasset Walid Kamal , Alsubaie Saud F. , Tantawy Sayed A. , Elyazed Tamer I. Abo , Elshehawy Ahmed A. 
Published: March 2019

Abstract
This study aimed to evaluate the association between physical activity level and health-related quality of life in community-dwelling middle aged and older adults in Egypt. Between May and August 2017, a cross-sectional study of 184 middle-aged and older adults between the ages of 55 and 64 years old (129 males and 55 females) with a mean age of 58 ± 4.3 years old participated in this study. Study participants were classified into 3 groups based on their level of physical activity (walking duration); low level of physical activity (<150 minutes/week), moderate level of physical activity (150–300 minutes/week), and high level of physical activity (>300 minutes/week). The health-related quality of life (HRQoL) was calculated using the Euro-Quality of life-5dimensions-3 levels scale questionnaire (EuroQol-5D-3L). Spearman's correlation coefficient was performed to determine the correlation between the physical activity level and HRQoL scores in community-dwelling middle-aged and older adults. The results showed a significant correlation between the physical activity levels and HRQoL dimensions. Significant differences were observed in the HRQoL scores between high, moderate and low-physical activity groups (P < .05). The moderate and high-physical activity groups had significantly higher HRQoL scores in all dimensions than low-physical activity group. The low-physical activity group showed a high predominance of the chronic disease compared to the high and moderate physical activity groups. It was concluded that high and moderate levels of physical activity have a great positive relationship with the HRQoL in community-dwelling middle-aged and older adults in Egypt. Recommendations should be dedicated to supporting the active lifestyle among the different population, particularly middle-aged and older adults.