bluuebunny/crossref_metadata_2025_split huggingface dataset:
MODERN POSSIBILITIES OF RATIONAL VITAMIN THERAPY IN PREGNANT WOMEN
Authors: Khashukoeva A. Z. , Agaeva M. I. , Ermilova K. A. , Moseshvili G. G. 
Published: September 2018

Insufficient nutrition is an urgent problem of modern healthcare. According to WHO, more than 2 billion people suffer from essential vitamin and mineral deficiencies, in particular vitamin A, iodine, iron and zinc [1]. The hypovitaminosis, as well as hypoelementosis pose the greatest threat to pregnancy and lactation, contributing to the development of miscarriages, intrauterine growth restriction, maternal mortality, labor complications, infectious pathology and adverse course of the neonatal period.Objective of the study: evaluation of the efficacy of the vitamin and mineral complex in correcting the nutritional status of patients during gestation.Materials and methods of the study: 33 pregnant women with threatened miscarriage of various genesis, who were admitted to the department of gynaecology, underwent a clinical and laboratory examination and treatment. In addition to the general clinical examination, all patients were assessed for plasma vitamin E and folic acid concentrations, which play a key role in embryogenesis. In addition to therapy aimed at prolonging pregnancy, all pregnant women received nutritional support in the form of a multivitamin drug.Results of the study: During the observation period, the condition of pregnant women improved significantly: signs of threatened miscarriage were eliminated, complaints of weakness, fatigue and sleep disturbance disappeared. All patients showed significantly higher plasma vitamin E and folic acid concentrations after the treatment.
Use of sodium-glucose co-transporter-2 inhibitors from clinical trial results to practical application in Russia
Authors: Lebedev D. A. , Babenko A. Yu. 
Published: September 2018

In clinical trials of drugs, including sodium-glucose co-transporter-2 inhibitors (SGLT2), the main reason for the discontinuation of the therapy are side effects. However, there are additional factors that affect the discontinuation of the therapy in real clinical practice. This paper presents assessment of adverse events against the background of SGLT2 therapy with empagliflozin, identification of risk factors for these phenomena, and analysis of the reasons for discontinuation of SGLT2 therapy in real clinical practice. The study included 86 patients with type 2 diabetes mellitus, who were prescribed empagliflozin SGLT2 for the first time. During the trial, 24 (27.9%) cases of side effects were reported: infection in the genitourinary tract – 13 (15.1%) cases, hypoglycemia – 7 (8.1%) cases, and hypotension – 4 cases (4.7%). In general, the risk factors for adverse events were female gender, BMI ≥ 30 kg/m2 and reduced estimated glomerular filtration rate (eGFR<60 mL/min/1.73m2). The empaglyflosin therapy was discontinued in 37.1% of patients for the following reasons: the development of side effects – 11.6%, lack of efficacy of the therapy – 8.1%, the cost of the drug – 13.9%, other reasons – 3.5%. Thus, in real clinical practice, not only the development of side effects, but also socio-economic factors play an important role in supporting medication adherence.
Agronomic Cultivation, Chemical Composition, Functional Activities and Applications of Pereskia Species – A Mini Review
Authors: Maciel Vinicius B.V. , Yoshida Cristiana M.P. , Goycoolea Francisco M. 
Published: September 2018

Background:
The exploration of the plant biodiversity as a natural source to obtain
sustainable food products and new bioactive pharmaceutical compounds has been growing
significantly due to their abundance, safety and economy. Natural pharmaceutical and edible
compounds present some advantages when compared to synthetic ones, such as being chemically
inert and widely available. In this sense, plants of the genus Pereskia belonging to the
Cactaceae family, have been studied. It is an unconventional wild edible plant that contains a
large amount of protein and minerals. Studies have demonstrated their biological activities
and potential application in different areas such as pharmaceutical, medicinal and food.

Objective:
This review is focused on the chemical composition, functional properties, applications
on pharmaceutical, nutraceutical and food areas and formulation techniques to enhance
the stability and bioavailability of bioactive compounds from the underutilized wild edible
plant known as ora-pro-nobis (Pereskia aculeata or Pereskia grandifolia).

Conclusion:
The latest studies involving ora-pro-nobis demonstrated its great potential due to
its biological activities, which could stimulate further investigations. The utilization of this
plant as a natural source to supplement the diet, or to prepare new food products and pharmaceutical
formulations is an attractive approach to explore and fully realize the potential of the
rich biodiversity found in Brazil and in other countries.
Anesthetic-induced Myocardial Conditioning: Molecular Fundamentals and Scope
Authors: Guerrero Orriach Jose Luis , Escalona Belmonte Juan Jose , Ramirez Aliaga Marta , Ramirez Fernandez Alicia , Raigón Ponferrada Aida , Rubio Navarro Manuel , Cruz Mañas Jose 
Published: September 2018

Background:
The pre- and post-conditioning effects of halogenated anesthetics
make them most suitable for cardiac surgery. Several studies have demonstrated that the
mechanism of drug-induced myocardial conditioning is enzyme-mediated via messenger
RNA and miRNA regulation. The objective of this study was to investigate the role that
miRNAs play in the cardioprotective effect of halogenated anesthetics. For such purpose, we
reviewed the literature to determine the expression profile of miRNAs in ischemic
conditioning and in the complications prevented by these phenomena.

Methods:
A review was conducted of more than 100 studies to identify miRNAs involved in
anesthetic-induced myocardial conditioning. Our objective was to determine the miRNAs that
play a relevant role in ischemic disease, heart failure and arrhythmogenesis, which expression
is modulated by the perioperative administration of halogenated anesthetics. So far, no studies
have been performed to assess the role of miRNAs in anesthetic-induced myocardial
conditioning. The potential of miRNAs as biomarkers and miRNAs-based therapies involving
the synthesis, inhibition or stimulation of miRNAs are a promising avenue for future research
in the field of cardiology.

Results:
Each of the cardioprotective effects of myocardial conditioning is related to the
expression of several (not a single) miRNAs. The cumulative evidence on the role of miRNAs
in heart disease and myocardial conditioning opens new therapeutic and diagnostic
opportunities.

Conclusion:
Halogenated anesthetics regulate the expression of miRNAs involved in heart
conditions. Further research is needed to determine the expression profile of miRNAs after
the administration of halogenated drugs. The results of these studies would contribute to the
development of new hypnotics for cardiac surgery patients.
Interferon-λ3 as a Predictor of Survival in Hemodialysis Patients.
Authors: Grzegorzewska A.E. , Swiderska M.K. , Warchol W. 
Published: September 2018

Background: IFNL4 polymorphisms are associated with circulating IFN-λ3,
and higher plasma IFN-λ3 are associated with higher production of antibodies to HBV
surface antigen (anti-HBs). The IFNL4 rs8099917 T allele and anti-HBs development in
response to HBV vaccine are associated with better survival in hemodialysis (HD)
patients.

Objective:
To show whether plasma IFN-λ3 is also a predictor of survival in HD
patients.

Methods:
Plasma IFN-λ3 was measured in 135 HD patients who were followed-up for
2.6 years. Survival probability was tested using the Kaplan-Meier method and the Cox
proportional hazard model.

Results:
Plasma IFN-λ3 (ng/L) was 116.8 (20.4–227.5) in survivors on HD (n=89,
65.9%), 75.1 (36.0-228.8) in deceased patients (n=37, 27.4%), and 109.0 (40.0–232.7)
in subjects submitted to kidney transplantation (n=9, 6.7%). IFN-λ3 was lower in
deceased patients than that in all remaining patients (P=0.039) and patients who
continued HD without transplantation (P=0.028). IFN-λ3 and anti-HBs titers were
correlated (r=0.587, P<0.000001). Patients showing IFN-λ3 >126.1 ng/L (3rd tertile)
presented better survival compared with patients with IFN-λ3 in the 1st (<73.8 ng/L,
P=0.005) and 2nd (≥73.8 - <126.1 ng/L, P=0.013) tertiles. Each decrease in IFN-λ3 per
10 ng/L was associated with a hazard ratio equal to 1.076 (95%CI 1.015–1.140,
P=0.013). In multivariate analysis, the independent predictors of survival were age
(P=0.008), dialysis modality (P=0.038), circulating IFN-λ3 (P=0.044), and diabetic
nephropathy (P=0.047), but not gender, dialysis duration prior to the study, mean arterial
pressure, BMI, CRP, albumin, 25(OH)D, or anti-HBs.

Conclusion:
Circulating IFN-λ3 is a promising predictor of HD patient survival.
TMJ Arthritis Imaging: Conventional Radiograph vs. CT Scan - Is CT Actually Needed?
Authors: Modgil Richa , Arora Karandeep Singh , Sharma Abhishek , Negi Lalit Singh , Mohapatra Shreeyam , Pareek Shubhangi 
Published: September 2018

Objective:The present study was conducted to evaluate the efficacy of conventional TMJ imaging in depicting osseous changes in mandibular condyle and glenoid fossa in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) by comparing the finding against CT and with an objective that if conventional TMJ imaging modality can appreciate the osseous changes in RA and OA then what is the need for CT scan. Thus further reducing the patient’s radiation dose.Materials and Methods:A total of 70 patients (40 Rheumatoid Arthritis; 30 Osteoarthritis) were taken in the study aged between 40 - 60 years and divided in to age groups. Then according to clinical history they were divided according to being symptomatic and asymptomatic. Further radiographic examination was carried out. First the trans-cranial view was obtained (conventional view left and right TMJ) and subsequently a CT scan was obtained and the interpretation was carried out to note the osseous changes like erosion, flattening, sclerosis and osteophyte formation.Results:After comparison of the two radiographic methods it was observed that both were equally efficacious in evaluating the osseous changes in arthritic patients.Conclusion:Thus, it was concluded that when both the radiographic methods (conventional and CT scan) are equally efficacious in evaluating the osseous degenerative changes of TMJ in arthritis. Thus we should prefer the conventional technique so that the patient in not exposed to unnecessary radiation dosage.
Does Prior Interprofessional Experience Influence the Attitudes of Graduate Healthcare Students about Interprofessional Education?
Authors: Oza Preeti D. , Nesbit Kathryn C. 
Published: September 2018

Background: Educational background and students’ preparedness influence interprofessional education (IPE). We studied if healthcare students’ prior exposure tointerprofessional collaborations and education influenced their attitudes andreadiness for IPE.Methods: Graduate students were surveyed in this cross-sectional study using the Readiness for Interprofessional Learning Survey (RIPLS). Independent variables included age, gender, type of healthcare program, diversity of clinical observation settings, and previous IPE coursework.Findings: Sixty-eight completed surveys included 60 percent in the 20 to 25-yearold group and 78 percent females. Controlling for age and gender, MANCOVA showed no group mean differences in the RIPLS.Conclusions: Students’ attitudes toward IPE are not associated with their professional program, previous IPE coursework, or exposure to interprofessional interactions in diverse clinical observations.
Study of the Equilibrium Sorption Humidity of the Materials of the Enclosing Constructions of Buildings at a Temperature -20 °C
Authors: Kiselev Igor Y. 
Published: September 2018

Equilibrium sorption humidity (further: sorption humidity) together with the thermal conductivity is the most important thermo-technical property of building materials, since itlargely determines the course of the process of heat- and moisture transfer through the enclosing constructions of buildings and, consequently, also the thermo-technical properties of these constructions. The isotherms of the absorption of vapors of water for foam concrete, cellular concrete, expanded-clay lightweight concrete, expanded-clay-pearlite lightweight concrete, expanded-shungizitlightweight concrete and arbolit were experimentally (by exiccator method) determined at temperatures -20, -10,4, +1,2, +20 and +35 °С. The analysis of the obtained results showed that the sorption humidity of all investigated materials increases with the temperature decrease from +35 °C to -10,4 °C. However, at a temperature -20 °С sorption humidity decreases, and what is more, that, it becomesless than the sorption humidity of these materials at a temperature of +20 °С. The reasons for the decrease of the sorption humidity of building materials at a temperature -20 °С in comparison with the values of this property at a temperature of +20 °C appears:

with the relative humidity of air φ< 80%: the sharp decrease of the mobility of water molecules of the first adsorbed monolayer at a certain temperature, which belongs to temperature range from -10,4 to -20 °С, and, as a result, a sharp increase of thelifetime of a water molecule in the first adsorbed monolayer;
with the relative humidity of air φ> 80% appears the second reason for the decrease of the equilibrium sorption humidity of building materials at a temperature -20 °C, namely, the freezing of some share of the capillary-condensed water and blocking by formed fixed ice the access of water vapor into the internal pore volume of material.
"Model Cultural Village": Architectural Dreams and Reality of the 1920-1930s
Authors: Kosenkova Yuliya L. 
Published: September 2018

The article is dedicated to the planning and development of the countryside in the 1920-1930s, both in the context of the rural social policy and in connection to the general orientation of Soviet town planning of this period. The idea of a "Model Cultural Village", which should've been shown to peasants as an example for imitation, was formed in the first post-revolutionary years. Depending on the changing construction policy of the State in the 1920-1930s, this idea was embodied in various projects, but all of them were far from the real situation in the countryside. In particular, attempts to create "exemplary" and then the "standard" projects of the planning of collective and state farm settlements, not based on the study of specific data, are considered.
The article shows the birth of scientific approach to the individual rural design based on pre-project studies in the second half of the 1930s. Such an approach was developed by the institutes of communal hygiene, but it did not manage to develop before the World War II. The social life basis in the countryside was unsustainable, and in the pre-war years the state policy regarding the planning of the countryside became much more strict. The struggle with the so-called "extravagances" began.
This trend was in contradiction with the slogan of "blurring the differences between urban areas and the countryside". The article shows the gradual simplification of the concept of "agro­town" - from agro-industrial plants, conceived in a big way in thelate 1920s, to a minimum equipping of the countryside. At the same time, the search for a visual image of the Soviet countryside was mainly reduced to competition projects of various "types" of clubs and community centers.
The Effect of Information Opacity and Accounting Irregularities on Personal Lending Relationships: Evidence from Lender and Manager Co-Migration
Authors: Khan Urooj , Li Xinlei , Williams Christopher D. , Wittenberg-Moerman Regina 
Published: September 2018

ABSTRACT
We examine how personal lending relationships between lenders and managers are affected by information and accounting environments of borrowing firms. We address this question by exploring whether, following managerial turnover, lenders migrate with the manager from the firm where a relationship developed (origin firm) to the manager's new firm (destination firm). We find that the opacity of the external information environment of the destination firm significantly increases the probability of lenders' co-migration, while accounting irregularities at both the destination and origin firms decrease it. We also show that co-migration is affected by a lender's monitoring efficiency. A lender's monitoring efficiency increases its co-migration probability when a manager moves to an opaque firm, but not when she moves to a transparent one. When the destination or origin firm experiences accounting irregularities, even lenders with strong monitoring capabilities are mostly reluctant to continue their relationship with a migrating manager.
Use of EU Funds in Promotion of Peripheral Areas
Authors: Stawicki Maciej 
Published: September 2018

Abstract
Subject and purpose of work: The aim of this paper is to assess the use of EU funds in promotion of peripheral areas on the example of five provinces of Eastern Poland. The detailed objectives are defined as follows: identification of projects co-financed by the EU aimed at promoting economy or tourism, including promotion of tourism-related products and assessment of using the EU funds in promotion of Polish enterprises abroad. Materials and methods: The research material is a database of projects co-financed from EU funds for 2007-2013, projects devoted to carrying out promotional activities (economic or tourist promotion) were selected for the analyses. Results: Spatial and quantitative diversification of promotional activities co-financed from EU funds in Eastern Poland was quite significant, with the highest absorption in the Lublin province. Among beneficiaries implementing promotional projects the largest group were entrepreneurs and local governments, primarily at the commune level. Conclusions: In the examined area, EU funds were used primarily to promote enterprises on foreign markets, also through participation in trade fairs organised on many continents, and to promote economy and tourism of local government units.
DETERMINANTS OF PUBLIC DEBT IN LOWER MIDDLE INCOME COUNTRIES
Authors: Thuan Vu Duc 
Published: September 2018

The ever increasing of public debt has been affecting the financial stability of both high and low income countries for years and is a considerable subject to various author all around the world. The aim of this study is to understand which all factors influence the public debt in lower middle-income countries using DGMM regression method. With the dataset of 40 countries during the 1996-2015, the study provides empirical evidences on the role of macroeconomic factors on changes of public debt in lower middle-income countries, including trade openness, interest rates, budget surplus, inflation, economic growth, foreign direct investment, infrastructure, scale of the financial system. However, the unemployment rate does not have any impact whatsoever on debt to GDP ratios of these countries for over the period.
Repositórios para tecnologias sociais de área rural em Brasília
Authors: Peres Monica Regina , Assumpção Luiz uiz Carlos Flores 
Published: September 2018

O objetivo deste estudo é o demonstrar a indicação de um projeto de aplicação das técnicas e ferramentas da área da Ciência da Informação no apoio a disseminação e utilização da informação de Tecnologias Sociais desenvolvidas no âmbito dos núcleos rurais do Lago Norte, Brasília, Distrito Federal. Assim, a metodologia indicada é uma pesquisa aplicada com utilização de pesquisa de campo com abordagem qualitativa e quantitativa. Como resultados um site da instituição proponente com DSpace e AtoM. Podemos concluir que a utilização dos repositórios disponibilizará e propiciará o acesso as informações sobre as Tecnologias Sociais desenvolvidas pela comunidade de moradores dos núcleos rurais da Serrinha do Paranoá, possibilitando a replicação e a aprendizagem ampliando a sustentabilidade da região.
Koyunlarda Üremenin Denetlenmesinde Güncel Yaklaşımlar
Authors: AKAL Eser , AKDAĞ Ceyhan 
Published: September 2018

Neolitik Çağ’da (M.Ö. 7-6) evcilleştirilmiş olan koyun, eski insanlardan
beri günümüze kadar yün, et ve süt üretimi amacıyla yetiştirilmektedir.
Türkiye’de de neredeyse her bölgede çeşitli koyun ırklarının (Merinos, Akkaraman,
Morkaraman, Dağlıç, Kıvırcık, İvesi, Sakız, İmroz, Tuj, Hemşin, Herik)
yetiştiriciliği yapılmaktadır. Dünyada koyun sayısında bir artış gözlenirken
ülkemizde 1980’de koyun varlığı 46 milyon iken bugün bu sayının 31 milyona
gerilediği görülmektedir. Daha verimli bir üretim için teknolojiden
faydalanarak modern yetiştiricilik hedeflenmelidir. Bu amaçla koyun
yetiştiriciliğinde masraflar artırmadan iyi verim elde etmek ve hayvanların
üreme performanslarını üst seviyeye çıkarmak için çeşitli yöntemler
kullanılmaktadır. Teknolojik yeniliklere ilaveten doğal yöntemler ve çeşitli
hormonlar kullanılarak koyunların üretimi denetim altına alınabilmektedir.
Böylece dölverimde artışlar mümkün hale gelebilmektedir. Bu yöntemler başlıca;
koyunların fotoperiyodik bir siklus düzeni olduğundan, ışık uygulamaları ve
normal siklus içerisindeki hormonların (Progestagenler, PMSG, GnRH, PGF2α)
taklidi yer alır. Bu seminerin amacı koyunlarda üremenin denetlenmesi amacıyla
yapılan uygulamalar hakkında bilgiler vererek turlere göre uygun prosedürleri
açıklamaktır.
Turkey’s Volte-Face Politics: Understanding the AKP’s Securitization Policy toward the Syrian Conflict
Authors: Aghaie Joobani Hossein , Adısönmez Umut Can 
Published: September 2018

Throughout its Republican history, Turkey has attempted to formulate a “non-interventionist” foreign policy toward its neighbouring countries. Since the onset of the Arab Uprisings, however, the ruling Justice and Development Party (AKP) has abjured the traditional policy of “non-military engagement”, adopting instead an assertive and security-oriented foreign policy that has paved the way for the securitization of the Syrian conflict in terms of its Kurdish component and of wider geopolitical aspects. This article aims to explore why and in what ways this abrupt shift toward securitization has occurred while discussing its broader implications on Turkish domestic politics as well. Using the Copenhagen School’s securitization theory, the article will unpack and analyse the internal and external dimensions of threat construction and otherization processes underlying Ankara’s securitization policy toward Syria to make the case for the obsolescence of Turkey’s traditional non-interventionist policy, which, we argue, results from an ontological insecurity approach toward the Syrian conflict. The article finds that Turkey’s securitization policy (i.e. interventionist approach) was chiefly driven by the fear of Kurdish autonomy and the growing Russo-Assad-Iranian alliance in Syria; and by the grand ambition of bringing the Muslim Brotherhood into power in Syria and consolidating Turkey’s agential importance in Western security architecture under the aegis of the US.