bluuebunny/crossref_metadata_2025_split huggingface dataset:
Herausforderungen eines strukturierten Ausfallmanagements in einem regionalen Klinikverbund als Alternative zur Leiharbeit
Authors: Krebs Stephanie , Hasseler Martina , Lietz Anna Larina 
Published: October 2019

Zusammenfassung
Zielsetzung In der vorgestellten explorativen Datenerhebung werden der Bedarf und mögliche Herausforderungen hinsichtlich eines strukturierten Ausfallmanagements in einem Klinikverbund erläutert, was eine Alternative zur Nutzung von Leiharbeit darstellen kann.
Methodik Zur Erhebung der Daten wurden leitfadengestützte Interviews nach Witzel (1985) mit verschiedenen Stakeholdern geführt. Anschließend wurden diese nach der qualitativen Inhaltsanalyse nach Mayring (2016) ausgewertet.
Ergebnisse Berufsgruppend übergreifend wurde große Skepsis gegenüber der Forschungsidee eines strukturierten Ausfallkonzepts in einem Klinikverbund geäußert. Es wurde ein Bedarf gesehen, dass die Gesamtanzahl von Pflegekräften erhöht werden muss, um eine Patientenbetreuung 24 Stunden gewährleisten zu können. Darüber hinaus wurden zahlreiche Herausforderungen beschrieben.
Schlussfolgerung Die benannten Herausforderungen spiegeln die aktuelle Situation im Hinblick auf den demografischen Wandel, den Fachkräftemangel und der bestehenden Unzufriedenheit verschiedener Berufsgruppen im deutschen Gesundheitswesen wider. Positive Effekte der Zusammenarbeit in Klinikverbünden wurden auf Grund etablierter Wettbewerbsgedanken nicht erkannt. Ebenso die Möglichkeit mit Hilfe von Organisations- und Personalentwicklungsmaßnahmen oder einem passgenauen Change Management, die Situation in der Pflege zu verbessern. Es zeigt sich, dass ein Generationsmanagement, Kommunikation und Transparenz sowie Innovationsbestreben fehlen, jedoch unerlässlich sind.
Eglerisine, a Novel Sesquiterpenoid Tropolone from Dulacia egleri with Antiproliferative Effect against an Acute Myeloid Leukemia Lineage
Authors: R. de Novais Leice M. , Ferreira Luiz F. , de Sousa Paulo T. , Ribeiro Tereza A. N. , Jacinto Marcos J. , dos Santos Carlos H. C. , de Carvalho Mário G. , Torquato Heron F. V. , Paredes-Gamero Edgar J. , Silva Virgínia C. P. 
Published: October 2019

AbstractChemical investigation of the stems of Dulacia egleri resulted in the isolation of eglerisine (1), a compound with a rare sesquiterpenoid tropolone skeleton. Its structure was determined by analysis of spectrometric and spectroscopic data, including HRESIMS, 1D, and 2D NMR. The antiproliferative effects of eglerisine were tested in human leukemia lineages. In the Kasumi-1 lineage, an acute myeloid leukemia cell line, eglerisine reduced cell metabolism, as determined by the resazurin assay. Eglerisine did not induce cell death by either apoptotic or necrotic mechanisms. However, a reduction of the absolute number of cells was observed. Eglerisine induced cell cycle arrest after 72 h of treatment by phosphorylation of H2AX histone, reducing the S phase and increasing the G2 phase of the cell cycle.
Implant Reconstruction in Nipple Sparing Mastectomy
Authors: Chu Carrie K. , Davis Matthew J. , Abu-Ghname Amjed , Winocour Sebastian J. , Losken Albert , Carlson Grant W. 
Published: October 2019

AbstractNipple sparing mastectomy has been popularized in the modern era of breast cancer treatment due to its touted advantages with regard to resultant body image and reconstructive outcome. Implant-based techniques remain the most prevalent means of breast reconstruction. Special considerations regarding patient selection and technique are reviewed for implant reconstruction in the setting of mastectomy with nipple preservation. Applications for prepectoral and direct-to-implant reconstruction are discussed and published outcomes are summarized.
CaM kinase II regulates cardiac hemoglobin expression through histone phosphorylation upon sympathetic activation
Authors: Saadatmand Ali Reza , Sramek Viviana , Weber Silvio , Finke Daniel , Dewenter Matthias , Sticht Carsten , Gretz Norbert , Wüstemann Till , Hagenmueller Marco , Kuenzel Stephan R. , Meyer-Roxlau Stefanie , Kramer Martin , Sossalla Samuel , Lehmann Lorenz H. , Kämmerer Susanne , Backs Johannes , El-Armouche Ali 
Published: October 2019

Significance
Posttranslational modifications of the histone 3 (H3) tail in response to stress represent highly conserved epigenetic processes. However, the regulatory function of histone phosphorylation has hardly been studied in postmitotic cardiomyocytes. Here, we identified CaMKII as a catecholamine-sensitive kinase phosphorylating H3S28. We identified CaMKII-dependent H3S28p-regulated genes including hemoglobin, pointing to a previously unrecognized role of CaMKII for cardiac hemoglobin homeostasis. This study raises fundamental questions about the role of hemoglobin in nonhematopoietic cells such as cardiomyocytes and about the role of CaMKII for hematopoesis.
Airborne nanoparticle (Nanoaerosol) sampling efficiency analysis based on filtration on TEM grid
Authors: Xiang M , Morgeneyer M , Philippe F , Bressot C 
Published: October 2019

Abstract
The scientific and technological issues associated with the characterization of the exposure of nano-aerosols is a huge technological challenge. Nano-aerosol measurement is a key point to characterize nanoparticle exposure. Transmission electron microscopy (TEM) coupled with energy-dispersive X-ray (EDX) is a comprehensive tool for determining size distributions and elemental compositions. Individual particle analysis allows the determination of size, morphology, specific surface, and elemental composition. Techniques allowing sampling on adapted analysis support TEM grids are of great interest to aerosol analysis: by using MPS and TEM analysis, sampling is directly and easily performed. The current paper explores the available theoretical models which assess sampling efficiency according to the chosen empirical approach. The recent studies which use this method are also briefly introduced.
Occupational risk assessment during explosion severity tests of carbon black and MWCNT in a laboratory
Authors: Bouhoulle Elodie , Sinaba Tiécoura , Laruelle Robin , Dalle Morgane , Aguerre-Chariol Olivier , Breulet Hervé , Le Bihan Olivier 
Published: October 2019

Abstract
Risk assessment has been conducted by quantitative and qualitative methods during explosion severity tests in a 20 L sphere for carbon black (N990) and MWCNT (NC7000™). The qualitative risk assessment was performed by control banding with CB Nanotool and StoffenManager Nano. The methodology for the quantitative assessment was based on general recommendations for exposure measurement assessment and an easy-to-use operational sampling approach. The results enabled to highlight a few sources of nanomaterials emission during the tests. It led also to the finding that the dynamic barrier provided by the local exhaust ventilation system can be temporarily weakened due to overpressure events. Based on the comparison of the measurements with the risk assessment results, the relevance of the selected control banding tools was assessed.
Occupational exposure to LTA Nanozeolites: strategies of exposure monitoring and toxicity evaluation
Authors: Ferrante R. , Ursini C.L. , Boccuni F. , Tombolini F. , Fresegna A.M. , Ciervo A. , Maiello R. , Iavicoli S. , Cavallo D. 
Published: October 2019

Abstract
Nanozeolites (NZs) are increasingly used in several sectors, but very few data are available on their toxicity. Therefore in this study we aimed to apply a standardized strategy to assess the occupational exposure integrated to an in vitro model useful to evaluate potential toxic effects in the case study of LTA-NZs.
Particle number concentration (PNC) values greater than the background significant level were highlighted during the production process phase of LTA NZs. The increase of PNC in the typical size range of produced NZs (around 100nm) and the presence of airborne NZs and their agglomerates in the workplace were confirmed by both real-time (CPC and FMPS) and off-line (ICP-MS and SEM-EDX) data analysis.
We also investigated the potential cyto-genotoxicity of NZs produced in the factory, on human alveolar cells (A549) exposed to 10-100μg/mL. We evaluated cell viability/apoptosis by cytofluorimetric assay, membrane damage by LDH release and DNA damage by Fpg-comet assay. We found a slight increase of apoptotic cell % at 50 and 100μg/mL. We found slight, statistically significant, direct DNA damage and slight oxidative DNA damage.
These findings represent the first data integrating exposure characterization and potential genotoxicity of NZs and highlight the need to perform further studies to confirm such results.
Synthesis and characterization of calcium alginate and cellulose nanocrystal films for lead removal
Authors: Urzedo A L , Bernardes J S , Pedron T , Batista B L , Akiba N , Gaubeur I , Seabra A B 
Published: October 2019

Abstract
The contamination of water with lead (Pb) is a society concern since this metal as a toxic cation. Cellulose nanocrystals (CNC) are rod-like structures with variable size, which are prepared by acid hydrolysis of cellulose natural sources, so it is a renewable, biodegradable material, with good mechanical performance. Sodium alginate (SA) is a biopolymer, biodegradable and renewable. This biopolymer can chelate bivalent cations forming gel networks. This work focuses on the combination of these two natural biopolymers to create a film of calcium alginate with CNC with the aim to remove non-essential elements on contaminated water. SA and CNC were mixed forming a dispersion, then they were left to dry and reticulated with sodium chlorate (CaCl2) solution. To determine the adsorption kinetics, the films were put in contact with Pb solution, the mixture was maintained under agitation, at constant speed and temperature, the Pb and calcium (Ca) concentrations in supernatant aliquots were determined using the Inductively Coupled Plasma Optical Emission Spectroscopy (ICP OES) and Flame Atomic Absorption Spectroscopy (FAAS), respectively. The results were applied on three kinetic models of adsorption: pseudo-first order; pseudo-second order and Weber-Morris. Characterizations of films were carried by Fourier Transform Infrared (FTIR); Atomic Force Microscopy (AFM); Scanning Electron Microscopy (SEM). AFM and SEM topography study showed a very flat and smooth surface for the films. The adsorption of Pb onto film increased with time contact. Maximum adsorption of Pb was 3.5 mg per gram of film. The prepared films were characterized by AFM and SEM. FTIR confirmed the structure of both polysaccharides. The Pb adsorption experimental data showed an adjusting for pseudo-second model, agreeing with published papers. Further analysis should be done to evaluate isotherms of adsorption and methods for removing the non-essential elements of the film, with the aim of a possible reuse of it.
Nanomaterials exposure as an occupational risk in metal additive manufacturing
Authors: Sousa M , Arezes P , Silva F 
Published: October 2019

Abstract
Metal Additive Manufacturing (AM) is a process of joining metallic materials based on 3D model data, aiming the manufacture of three dimensional parts by the successive addition of material, usually layer upon layer. This technology is nowadays seen as an emerging one, showing exceptional perspectives of growth, being able to produce parts in various materials such as precious metals (for example gold, silver and platinum) and several metal alloys, such as aluminium, titanium, nickel, cobalt and magnesium based alloys, among others. However, as the range of feedstock materials, technologies and applications increases, so do the concerns about its impact on health and safety of those who are exposed to the particles emitted during these processes, particularly when AM uses metal powder. Regarding emissions, studies thus far show that nanomaterials are emitted during AM processes, a fact that rises the concern about its impacts and enhances the complexity of risk management on these processes. When risk management aims nanoscale, it becomes a true challenge as it deals with several different nanomaterials and the lack of systematic and standardized risk assessment methodologies. At this scale, risk management raises many doubts regarding the selection of quantitative or qualitative approaches, the identification, characterization and quantification of nanomaterials, the definition of occupational exposure limits and the outlining of control measures. Having this conscience, a review was developed to summarize some of the recent developments in the field of risk management of occupational exposure to nanomaterials during metal additive manufacturing. Additionally, this review emphasizes the need for more investigation about risks regarding nanomaterials in workplaces, which is essential to ensure workers’ safety conditions and preserve their health, as well as to make conscious decisions on risk assessment, public health, medical monitoring and control measures, namely the adoption of personal protective equipment.
Cytotoxicity and Antitumor Activity of Biogenic Silver Nanoparticles Against Non-Muscle Invasive Bladder Cancer
Authors: Ferreira L A B , Fóssa F G , Durán N , de Jesus M B , Fávaro W J 
Published: October 2019

Abstract
Bladder cancer is the fifth most common form of malignancy in the United States, and for most of the last three decades, the treatment and outcomes for patients with this disease have not changed. Nanomedicine aims to provide the means to target chemotherapies directly and selectively to cancerous cells and enhance their therapeutic efficacy. In this scenario, we employed biogenic Silver Nanoparticles (AgNPs) as an anticancer agent against non-muscle invasive bladder cancer (NMIBC). Bladder cancer was chemically induced with N-methyl-N-nitrosourea (MNU) on C57BL/6Junib female mice and treated by intravesical route with biogenic silver nanoparticles concentrations of 0.5, 0.2, and 0.05 mg/mL. The histopathological analyzes showed the treated with AgNP 0.5 group presented 42.85% of pTa, 28.57% of pTis and 28.57% of pT1, indicating that this treatment was not effective in regressing the neoplastic lesions. MNU + AgNP 0.2 group showed 28.57% of tumor regression, being these animals showed flat hyperplasia (28.57%). Finally, treatment with 0.05 AgNP led to 57.13% of tumor regression, with 14.28% of the animals showing normal urothelium and 42.85% showing flat hyperplasia, considering a benign lesion. Further, to understand the antitumor effect of AgNPs, we evaluated the molecular mechanism of cytotoxicity in human bladder carcinoma 5637 cell. The results showed the dose-time dependent cytotoxicity, and detailed analysis demonstrated the induction of cell death via apoptosis. Besides, we found that AgNP inhibition in cell migration and proliferation. Thus, these findings confirm the antitumor properties of AgNPs and suggest that they may be a cost-effective alternative and promising candidate for the treatment of bladder cancer.
Relevance of pin-on-disc and inertia dynamometer bench experiments for braking emission studies
Authors: Philippe F , Xiang M , Bressot C , Chen Y , Guingand F , Charles P , Loigerot J , Morgeneyer M 
Published: October 2019

Abstract
Over the last years, the task of reducing automobile pollution was focused on the car’s engine. Now, the non-exhaust emission becomes a major contributor, and its control is the next objective to reach the zero-emission car. A major part of those non-exhaust emissions comes from brake wear, caused by the friction between the brake disc and pads. This emission is the result of complex tribological phenomena that has still to be determined. Nevertheless, this emission remains controllable and is the next lever for reducing car pollution. The problem of this field is the non­comparable results obtained by stakeholders due to their different measurement protocol. The first challenge is, thus, to define the best protocol in order to get a representative, reliable and repeatable measurement of particle emissions. The present article discusses a step of the selection process: which laboratory indoor method is the best for simulating the generation of braking particles? The pin-on-disc and the inertia dynamometer bench are the only two existing methods for braking simulation.
Structure and Electrical Erosion Resistance of An Electro-Explosive Coating of the ZnO-Ag System
Authors: Romanov D A , Moskovskii S V , Sosnin K V 
Published: October 2019

Abstract
For the first time, electroerosion-resistant coatings of the ZnO-Ag system were obtained by electro-explosive spraying. The coating structure was investigated by atomic force microscopy and scanning electron microscopy. The formed coating is a homogeneous composite material consisting of a silver matrix and ZnO inclusions located in it. Tests of sprayed coatings for electrical erosion resistance under arc erosion conditions were carried out. A formation mechanism of hierarchical levels of the structure of electro-explosive coatings was suggested. The mechanism is based on theoretical concepts of the formation and evolution of fractal aggregates with diffusion-limited and cluster-cluster aggregations. Based on the electrical properties of silver and zinc oxide, the dependence of electrical contact resistance on the number of on/off cycles in the process of testing for electrical erosion resistance is substantiated.
Style Transfer for CNC Machine Input Data Preprocessing
Authors: Nikolaev E I , Zaharov V V , Zaharova N I 
Published: October 2019

Abstract
Advances in deep neural networks have led to impressive results in recent years. The new technologies such as cross-domain adaptation, reinforcement learning and generative adversarial networks have shown a real promise for industrial and real-life applications. In this paper, the results of the experimental research on designing, training and implementation of the preprocessing algorithm for the computer numerical control machine input were presented. The algorithm of neural network transfer of artistic style has demonstrated wide possibilities in the field of generating graphic content. This paper demonstrates the possibility of using a generating neural network for the synthesis of stylized images that can be used as input images for a computer numerical control machine. Thus, the proposed algorithm is pre-processing the input image. The design feature of the laser engraver does not allow styling using an arbitrary style image, so dotted or linearized binary images are used as a style. The proposed preprocessing algorithm allows synthesizing binary images reproduced by a laser engraver. At the same time, image generation is performed in one forward pass of the generating neural network.
Usage of Bioorganic Nano-fertilizer Nagro as Opportunity of Ecologization for Winter Rye Development (Secale Cereale)
Authors: Pinchuk L G , Piyanyh A V , Sergeeva I A , Konstantinova O B 
Published: October 2019

Abstract
On the basis of research of winter rye productivity dependence of Vlada and Tetra short cultivar from exposure of seed treatment and sowing with bioorganic nano-fertilizer Nagro in Kuznetskaya forest steppe of south-east in West Siberia (2015–2018 years), there was found out increasing of yield activity respectively to control (sowings without fertilizer) for Vlada cultivar – 15-28% and Tetra short – 4-13%. Number of falling increased for 5-23%. Wasn’t spotted correlation between hydrothermal conditions of vegetation and influence of biologics on studied productivity index.
Simulation of Transcendental Deformation Mode of Interchamber Pillars and Ore Deposit in the Course of Development of Bauxite Resources at Great Depth on the Example of Mine «Sevuralboksitruda»
Authors: Kosukhin N I , Sidorov D V , Yu Timofeev V 
Published: October 2019

Abstract
The publication describes the problem of transcendental deformation mode of interchamber pillar and ore deposit associated with the formation of hazardous zones in the rock mass in process of development of rockburst-hazardous rock masses at the great depth. Geomechanical software PRESS 3D URAL is used to assess the impact of the range of geological and technological factors on the mode of interchamber pillars deformation and ore deposit. The software allows to solve spatial problems in the elastic-plastic formulation. The results of step-by-step modeling of different mining and technical situations with a test of the bearing capacity of interchamber pillars showed that some of them can’t withstand the mountain pressure and go to the transcendental mode of deformation with subsequent destruction. Identification of the destroyed pillars allows to adjust the boundary conditions of loading the ore mass. At the same time the neglect of transcendental mode of deformation of interchamber pillars can lead to an undervaluation of the stress level in the ore mass by 1.5 or more times. This can lead to an error in predicting the parameters of zones dangerous due to rock bumps.
Management of Repair Service Structure of Industrial Enterprise When Transferring Repair Equipment for Outsourcing
Authors: Shimohin A V , Redreev G V , Pomogaev V M , Zaripova N A , Kirasirov O M 
Published: October 2019

Abstract
in modern conditions, when the equipment of domestic industrial enterprises is significantly worn out, it becomes important to use outsourcing repairs as a way to improve the reliability of equipment by ensuring the quality of repair. The decision to outsource is made on the basis of different criteria using different approaches, some of which have certain drawbacks. For example, a decision based on a revenue change might be wrong because it is not related to outsourcing. Multi-criteria approaches are ineffective due to mutual compensation of deteriorating and improving criteria. The algorithm of decision-making on outsourcing of repair of the equipment and the choice of service providers on the basis of comparison of costs of outsourcing and insourcing is presented.The widespread structure of repair service of the industrial enterprises is considered and its reorganization in the conditions of repair outsourcing application is offered. The criteria and method of their calculation for the possibility of evaluating the effectiveness of repair outsourcing equipment. To assess the effectiveness of the reorganization of the repair service, the ratio of repair time, the number of failures, the number of defects, the repair costs are taken. For the detection of improvement or deterioration in the quality of the repair after the use of outsourcing, you must use the product of these relations.