bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medical conditions and outcomes in 371 hoarded cats from 14 sources: a retrospective study (2011–2014)
Authors: Jacobson Linda S , Giacinti Jolene A , Robertson Jyothi 
Published: June 2019

Objectives The aims of this study were to: (1) describe the source, route of surrender and signalment of hoarded cats relinquished to the Toronto Humane Society (THS); (2) document the prevalence of medical conditions by group (place of origin); (3) compare medical conditions between institutional hoarding (IH) and non-institutional hoarding (NIH) environments; and (4) report length of stay (LOS) and outcomes in hoarded and non-hoarded cats. Methods A retrospective, descriptive epidemiological study was performed using THS records from between July 2011 and June 2014. The prevalence of medical conditions was calculated for the different groups. Univariable logistic regression with a random intercept to account for autocorrelation among animals from the same group was used to examine the influence of IH and NIH environments on selected medical conditions. LOS and outcomes were calculated for hoarded and non-hoarded cats. Results Three hundred and seventy-one hoarded cats from 14 sources were included. The majority (n = 352/371) were surrendered voluntarily, many with the assistance of a community intermediary. Upper respiratory infection (URI) was the most common medical condition (38% of cats), followed by dermatological disease (30%). The prevalence of medical conditions varied substantially between groups. The odds of URI at intake (odds ratio [OR] 4.35, P = 0.044) and chronic URI (OR 23.70, P <0.0001) were significantly greater for IH compared with NIH. Adoption rates, euthanasia rates and LOS were similar for hoarded and non-hoarded cats. Conclusions and relevance The different prevalence of medical conditions in groups of hoarded cats indicates a continuum of harm and severity in animal hoarding. Hoarded cats can have LOS and live release rates comparable with non-hoarded cats. Cats from IH were significantly more likely to have chronic URI. This study highlights the need for a greater focus on IH, as well as the role of community intermediaries and the potential for a harm reduction approach to animal hoarding.
The use of social services by older males
Authors: Meyer Seth J 
Published: June 2019

Summary In the fields of social work and social welfare, there have been many studies which have examined the use of social services. Few studies, however, have specifically explored the use of social services by older male clients (age 60 and older). There is little understanding in social work concerning how to best work with male clients. Using the 2012 Southeastern Pennsylvania Household Health Survey (n = 3042), this study examines how older males are using social services as compared to older females. Findings Specifically using a zero-inflated negative binomial regression model and logit models this study finds that older males, in general, are using fewer social services than older females. Looking at services supported through the Older Americans Act of 1965, it also identifies which services older males have a lower likelihood of using as compared to older females. Furthermore, instead of viewing all older males as a monolithic group, this study shows how intersectionalities in race, ethnicity, and socioeconomic status affect service use. Applications By having a greater understanding of which services older males are and are not using, nonprofit organizations can start exploring how to expand and improve services for this population. To improve outreach to older males, organizations should first explore if they are using services to begin with.
Introduction of Cobas Liat Influenza A/B for rapid point-of-care diagnosis of influenza infection in an acute trust
Authors: Brooke-Pearce Fran , Demertzi Elli 
Published: June 2019

Background: We aimed to evaluate the impact of a new molecular point-of-care test (POCT), the Cobas Liat Influenza A/B for rapid diagnosis of influenza within 20 min, on the operational workflow of the Trust, accurate diagnosis and potential cost savings during the winter of 2017–2018. Methods: A retrospective cohort study was conducted on all patients aged > 18 years tested for flu A/B by laboratory PCR in January 2017 and by POCT in January 2018. Results: From 21 December 2017 to 30 April 2018, a total of 1375 POCTs were performed with a total of 479 (35%) influenza-positive cases. Results demonstrated that 1046 (76%) suspected cases did not require isolation or were able to be discharged from Emergency Department (ED), once other risks had been ruled out. We particularly looked into the differences between the month of January 2017 (before POCT) and the month of January 2018. Discussion: Results demonstrate that influenza POCT had a positive impact on the Trust regarding prompt patient diagnosis and treatment, discharge decisions, improvement of patient bed management by avoiding unnecessary patient isolation and reducing bay closures, and significant reduction in length of stay in both positive and negative cases. Estimated cost savings were significant.
A Measure of Social Media Marketing: Scale Development and Validation
Authors: Khan Mohammad Furqan , Jan Anisa 
Published: June 2019

With the evolution of social media the world has witnessed an information explosion. The role of social media in influencing the consumer behavior is huge, but the studies conducted in these areas are insignificant. Scholars have identified different variables over time to study social media marketing, but functionality-based approach was only investigated by Babac (Impact of social-media use on brand equity of magazine brands: A qualitative study of Vogue Turkey, Unpublished Master’s thesis, 2011) and Tresna and Wijaya (iBuss Management, 3: 37–48, 2015). Tresna and Wijaya’s (iBuss Management, 3: 37–48, 2015) study was based on Instagram, therefore, their scale could not be used for Facebook, because of the difference in website functionalities. Most of the social media marketing activities are carried on Facebook and to measure these marketing efforts a research instrument is needed. Therefore, this study is an attempt to develop a measurement scale to assess the influence of social media functionalities. In order to identify the factors of social media, exploratory factor analysis (EFA) was run on a sample of 122 respondents in SPSS 20. EFA was run on 34 items and seven items were removed in the first round. In the second round EFA was run on the remaining 27 items and five items were dropped. Third time when EFA was run, all 22 items loaded well on the seven factors of social media with a cumulative variance of 82.95 percent. The scales reliability was tested by using Cronbach’s alpha which was above the threshold. Further the scale was also tested for convergent and discriminant validity, that indicated positive results. Therefore, 22 items scale to measure seven functionalities of social media websites was found to be reliable and valid. This study is unique because, a measurement scale to investigate the influence of social media functionalities of Facebook is developed. Previous study was based on Instagram and only six functionalities were measured, whereas this study has filled that gap by providing a full-fledged scale to measure the seven functionalities of social media. This scale can be further used to study the impact of these seven functionalities on various dimensions of consumer-based brand equity, purchase intentions, and brand experience.
Hip Function 6 to 10 Months After Arthroscopic Surgery: A Cross-sectional Comparison of Subjective and Objective Hip Function, Including Performance-Based Measures, in Patients Versus Controls
Authors: Wörner Tobias , Nilsson Johanna , Thorborg Kristian , Granlund Viktor , Stålman Anders , Eek Frida 
Published: June 2019

Background: Little is known about hip-related function, mobility, and performance in patients after hip arthroscopic surgery (HA) during the time that return to sports can be expected. Purpose: To evaluate measures of subjective and objective hip function 6 to 10 months after HA in patients compared with healthy controls and to compare objective function in the HA group between the operated and nonoperated hips. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 33 patients who had undergone HA (mean, 8.1 ± 2.6 months postoperatively) and 33 healthy participants matched on sex, age, and activity level were compared regarding subjective hip function (Copenhagen Hip and Groin Outcome Score [HAGOS]) and objective function including hip range of motion (ROM; flexion, internal rotation, and external rotation), isometric hip muscle strength (adduction, abduction, flexion, internal rotation, and external rotation), and performance-based measures: the Y Balance Test (YBT), medial and lateral triple-hop test, and Illinois agility test. Group differences were analyzed using independent-samples t tests. Paired-samples t tests were used for a comparison of the operated and nonoperated hips. Standard effect sizes (Cohen d) were provided for all outcomes. Results: The HA group reported worse subjective hip function than the control group (HAGOS subscores: d = –0.7 to –2.1; P ≤ .004). Objective measures of hip ROM ( d = –0.5 to –1.1; P ≤ .048), hip flexion strength ( d = –0.5; P = .043), and posteromedial reach of the YBT ( d = –0.5; P = .043) were also reduced in the HA group, although there were no significant differences between groups regarding the remaining objective measures ( d = –0.1 to –0.4; P ≥ .102 to .534). The only significant difference between the operated and nonoperated hips in the HA group was reduced passive hip flexion ( d = –0.4; P = .045). Conclusion: Patients who had undergone HA demonstrated reduced subjective hip function compared with controls 6 to 10 months after surgery, when return to sports can be expected. While most objective strength and performance test results were comparable between the HA and control groups at 6 to 10 months after surgery, the HA group presented with impairments related to hip mobility and hip flexion strength. No consistent pattern of impairments was found in operated hips compared with nonoperated hips.
CRISPR genome editing of murine hematopoietic stem cells to create Npm1-Alk causes ALK+ lymphoma after transplantation
Authors: Rajan Soumya Sundara , Li Lingxiao , Kweh Mercedes F. , Kunkalla Kranthi , Amin Amit Dipak , Agarwal Nitin K. , Vega Francisco , Schatz Jonathan H. 
Published: June 2019

Key Points
CRISPR/Cas9 genomic editing of wild-type hematopoietic stem cells generates Npm1-Alk, leading to ALK+ large-cell lymphomas in recipients. CD30+ postthymic T-cell lymphomas are polyclonal but transplantable to secondary recipients with long latency.
Biologic Significance of Magnetic Resonance Imaging Invisibility in Localized Prostate Cancer
Authors: Salami Simpa S. , Kaplan Jeremy B. , Nallandhighal Srinivas , Takhar Mandeep , Tosoian Jeffrey J. , Lee Matthew , Yoon Junhee , Hovelson Daniel H. , Plouffe Komal R. , Kaffenberger Samuel D. , Schaeffer Edward M. , Karnes R. Jeffrey , Lotan Tamara L. , Morgan Todd M. , George Arvin K. , Montgomery Jeffrey S. , Davenport Matthew S. , You Sungyong , Tomlins Scott A. , Curci Nicole E. , Kim Hyung L. , Spratt Daniel E. , Udager Aaron M. , Palapattu Ganesh S. 
Published: June 2019

PURPOSE Multiparametric magnetic resonance imaging (mpMRI) is used widely for prostate cancer (PCa) evaluation. Approximately 35% of aggressive tumors, however, are not visible on mpMRI. We sought to identify the molecular alterations associated with mpMRI-invisible tumors and determine whether mpMRI visibility is associated with PCa prognosis. METHODS Discovery and validation cohorts included patients who underwent mpMRI before radical prostatectomy and were found to harbor both mpMRI-visible (Prostate Imaging and Reporting Data System 3 to 5) and -invisible (Prostate Imaging and Reporting Data System 1 or 2) foci on surgical pathology. Next-generation sequencing was performed to determine differential gene expression between mpMRI-visible and -invisible foci. A genetic signature for tumor mpMRI visibility was derived in the discovery cohort and assessed in an independent validation cohort. Its association with long-term oncologic outcomes was evaluated in a separate testing cohort. RESULTS The discovery cohort included 10 patients with 26 distinct PCa foci on surgical pathology, of which 12 (46%) were visible and 14 (54%) were invisible on preoperative mpMRI. Next-generation sequencing detected prioritized genetic mutations in 14 (54%) tumor foci (n = 8 mpMRI visible, n = 6 mpMRI invisible). A nine-gene signature (composed largely of cell organization/structure genes) associated with mpMRI visibility was derived (area under the curve = 0.89), and the signature predicted MRI visibility with 75% sensitivity and 100% specificity (area under the curve = 0.88) in the validation cohort. In the testing cohort (n = 375, median follow-up 8 years) there was no significant difference in biochemical recurrence, distant metastasis, or cancer-specific mortality in patients with predicted mpMRI-visible versus -invisible tumors (all P > .05). CONCLUSION Compared with mpMRI-invisible disease, mpMRI-visible tumors are associated with underexpression of cellular organization genes. mpMRI visibility does not seem to be predictive of long-term cancer outcomes, highlighting the need for biopsy strategies that detect mpMRI-invisible tumors.
Effectors of the spindle assembly checkpoint are confined within the nucleus of Saccharomyces cerevisiae
Authors: Heasley Lydia R. , DeLuca Jennifer G. , Markus Steven M. 
Published: June 2019

ABSTRACT
The spindle assembly checkpoint (SAC) prevents erroneous chromosome segregation by delaying mitotic progression when chromosomes are incorrectly attached to the mitotic spindle. This delay is mediated by mitotic checkpoint complexes (MCCs), which assemble at unattached kinetochores and repress the activity of the anaphase promoting complex/cyclosome (APC/C). The cellular localizations of MCCs are likely critical for proper SAC function, yet remain poorly defined. We recently demonstrated that in mammalian cells, in which the nuclear envelope disassembles during mitosis, MCCs diffuse throughout the spindle region and cytoplasm. Here, we employed an approach using binucleate yeast zygotes to examine the localization dynamics of SAC effectors required for MCC assembly and function in budding yeast, in which the nuclear envelope remains intact throughout mitosis. Our findings indicate that in yeast, MCCs are confined to the nuclear compartment and excluded from the cytoplasm during mitosis.
Dosimetric performance of two linear accelerator-based radiosurgery systems to treat single and multiplebrain metastases
Authors: Ueda Yoshihiro , Ohira Shingo , Yamazaki Hideya , Mabuchi Nobuhisa , Higashinaka Naokazu , Miyazaki Masayoshi , Teshima Teruki 
Published: June 2019

Objective:
To evaluate and compare the dosimetric plan quality for noncoplanar volumetric arc therapy of single and multiple brain metastases using the linear accelerator-based radiosurgery system HyperArc and a robotic radiosurgery system.

Methods:
31 tumors from 24 patients were treated by stereotactic radiosurgery using the CyberKnife system. CT images, structure sets, and dose files were transferred to the Eclipse treatment planning system for the HyperArc system. Dosimetric parameters for both plans were compared. The beam-on time was calculated from the total monitor unit and dose rate.

Results:
For normal brain tissue, the received volume doses were significantly lower for HyperArc than for CyberKnife_G4 and strongly correlated with the planning target volume (PTV) for cases of single brain metastasis. In addition, the difference in volume dose between CyberKnife_G4 and HyperArc was proportional to the PTV. For multiple brain metastases, no significant difference was observed between the two stereotactic radiosurgery systems, except for high-dose region in the normal tissue. In low dose for brain minus PTV, when the maximum distance among each target was above 8.0 cm, HyperArc delivered higher dose than CyberKnife_G4. The mean ± SDs for the beam-on time were 15.8 ± 5.3 and 5.6 ± 0.8 min for CyberKnife_G4 and HyperArc, respectively (p &lt; .01).

Conclusion:
HyperArc is best suited for larger targets in single brain metastasis and for smaller inter tumor tumor distances in multiple brain metastases.

Advances in knowledge:
The performance of HyperArc in comparison with CyberKnife_G4 was depended on defined margin and tumor distances.
Rationale and design of perioperative myocardial ischemia: a protocol for troponin monitoring, prognostic thresholds, economic analysis and further insights into pathophysiology for non-cardiac surgery patients
Authors: Popova Ekaterine , Paniagua Iglesias Pilar , Alvarez Garcia Jesus , Vives Borras Miguel , Carreras Costa Francesc , García-Moll Marimón Xavier , Rivas Lasarte Mercedes Pilar , Gonzalez Osuna Aranzazu , Martinez Bru Cecilia , Font Gual Adria , Diaz Jover Ruben , India Aldana Inmaculada , Azparren Cabezon Gonzalo , Carles Lavila Misericordia , Rué Monné Montserrat , Zamora Romero Javier , Martinez Zapata MªJosé , Alonso-Coello Pablo 
Published: June 2019

Introduction: Worldwide, near 200 million adults undergo major non cardiac surgery each year, and 10 million of them are estimated to suffer a myocardial injury after non-cardiac surgery (MINS), defined as an elevated high sensitive troponin T (hs-cTnT) in the first 3 days after surgery. Troponin levels need to be monitored in order to diagnose MINS, high sensitive cardiac Troponin T (hs-cTnT) assays being currently the most frequently used. Perioperative hs-cTnT screening could lead to care decisions that can potentially improve clinical outcomes. However, many of the clinical and economic implications of perioperative hs-cTnT monitoring remain unclear, and need to be elucidated. Methods and analysis: Prospective cohort that will include patients with high cardiovascular risk undergoing major non-cardiac surgery, expected to require at least an overnight hospital admission. Three determinations of hs-cTnT in each patient (before surgery, at 48, and 72 hours after surgery) will be obtained. We will determine the incidence and prognosis of MINS, and calculate prognostically relevant thresholds for pre- and post-operative hs-cTnT. We will also conduct a cost-effectiveness analysis of hs-cTnT screening, compared with usual care. Finally, using computed tomography angiography (CTA) and cardiac magnetic resonance imaging (MRI), we aim to elucidate further the pathophysiology of MINS. Ethics and dissemination: Our center had Ethics approval before including patients. Written informed consent is required for all patients before inclusion. The study will evaluate the feasibility and impact of implementing an hs-cTnT monitoring program at a tertiary hospital, as well as its cost-effectiveness, determine pre and postoperative thresholds of hs-cTnT and finally, evaluate potential mechanisms involved in perioperative ischemic events. The dissemination plan includes publishing the results in a policy-influencing journal, conference presentations, engagement of influential medical organizations, and taking published results to real practice.
Diversity issues in Nigeria’s healthcare sector: implications on organizational commitment. A cross-sectional study
Authors: Ibidunni Ayodotun Stephen , Olawande Tomike , Olokundun Maxwell , Iruonagbe Charles , Adelekan Iyanu 
Published: June 2019

Background: Workplace diversity is increasingly gaining the attention of healthcare organizations, especially in developing countries like Nigeria. However, little is understood from existing literature about how workforce diversity affects employees’ satisfaction and organisational commitment in the workplace. Consequently, this paper showed the direct and mediating relationships between diversity of workforce, job satisfaction and employee commitment to the organization. Methods: Copies of the structured questionnaire have been given to 133 public healthcare employees in Nigeria’s Ministry of Health in Lagos state. Statistical analysis for the study included descriptive measures and multi-variate analysis, using structural equation modelling. Results: Outcomes from statistical analysis supports direct and mediating relationships between the research variables. Gender and ethical diversity had significant influences on job satisfaction at r = 0.35 (p < 0.05) and r = 0.28 (p < 0.05) respectively. The following mediating relationships were also statistically confirmed: job satisfaction related with affective commitment (r = 0.41, p < 0.05) and normative commitment (r = 0.26, p < 0.05). Conclusions: Based on the results of the statistical analysis, the study concludes that there is a relationship between diversity of employees and job satisfaction, diversity of employees and organizational commitment and the influence of work satisfaction on organizational commitment.
Patterns of neurobehavioral functioning in school-aged survivors of neonatal jaundice and hypoxic-ischemic encephalopathy in Kilifi, Kenya: A cross-sectional study
Authors: Magai Dorcas N. , Newton Charles R , Mwangi Paul , Koot Hans M. , Abubakar Amina 
Published: June 2019

Background: Studies in high-income countries have reported that school-aged children who survive neonatal jaundice (NNJ) and hypoxic-ischemic encephalopathy (HIE) develop long-term neurocognitive problems. However, less is known about the patterns of functioning in school-aged survivors of NNJ and HIE in sub-Saharan Africa. This study examined patterns of functioning in school-aged children who survived NNJ and HIE in Kilifi, Kenya. Methods: This is a cross-sectional study that included 107 survivors of NNJ/HIE (64 with NNJ, 43 with HIE), aged 6-12 years, admitted to Kilifi County Hospital on the Kenyan Coast. The Gross Motor Function Classification System (GMFCS), Adapted Communication Profile, Raven’s Coloured Progressive Matrices (RCPM) and an epilepsy screening tool were used to assess gross motor function, communication function, intellectual functioning, and epilepsy, respectively. Results: Most of the survivors of NNJ (95.2%) and HIE (95.3%) had no impairments in gross motor functioning. A small percentage of the children in the NNJ and HIE groups had profound problems in their communication (4.7% and 4.7%); expressive communication function (4.7% and 4.7%); social functions (3.1% and 2.3%); receptive communication (4.7% and 2.3%); and communicative effectiveness (4.7% and 2.3%). Cognitive impairment was reported in 10.9% and 11.9% for NNJ and HIE survivors, respectively. Active epilepsy was detected in 1.6% of survivors of NNJ and 2.3% of survivors of HIE. All children had normal hearing and visual functioning except one participant who presented with mild visual acuity problems. Conclusions: Most school-aged children who survive with NNJ and HIE have normal motor and communication function; however, one in ten are likely to present with lowered intellectual functioning compared to the normative sample.