bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection and characterization of a rhabdovirus causing mortality in black bullhead catfish, Ameiurus melas
Authors: Bedendo Giulia , Panzarin Valentina , Fortin Andrea , Zamperin Gianpiero , Pretto Tobia , Buratin Alessandra , Quartesan Rosita , Sabbion Matteo , Salogni Cristian , Pascoli Francesco , Toffan Anna 
Published: March 2018

AbstractThis study fully describes a severe disease outbreak occurred in 2016 in black bullhead catfish farmed in Italy. Affected fish showed nervous clinical signs as well as emaciations and haemorrhagic petechiae on the skin at the fin bases, abdomen and gills. Viral isolation in cell culture allowed the subsequent identification of a rhabdovirus, tentatively named ictalurid rhabdovirus (IcRV), through electron microscopy, immunofluorescence and whole genome sequencing (WGS). The newly isolated virus, together with 14 additional viral strains stored in our repository and detected during similar mortality episodes in the period 1993–2016, was phylogenetically analysed on the basis of the nucleoprotein and the glycoprotein nucleotide and amino acid sequences. The genetic distances among Italian IcRV strains were also estimated. Our results show that all the IcRV strains belong to the genus Sprivivirus and are closely related to the tench rhabdovirus (TenRV). Italian catfish production is constantly decreasing, mainly due to viral infections, which include the newly characterized IcRV. Data presented in this work will assist to investigate the molecular epidemiology and the diffusive dynamics of this virus and to develop adequate surveillance activities.
Liraglutide ameliorated peripheral neuropathy in diabetic rats: Involvement of oxidative stress, inflammation and extracellular matrix remodeling
Authors: Moustafa Passant E. , Abdelkader Noha F. , El Awdan Sally A. , El‐Shabrawy Osama A. , Zaki Hala F. 
Published: March 2018

AbstractDiabetic peripheral neuropathy is one of the most common microvascular complications that occurs with both type 1 and type 2 diabetes mellitus. It has a significant negative impact on patients’ quality of life; as it starts with loss of limbs’ sensation and may lead to lower limb amputation. This study aimed at investigating the effect of liraglutide on peripheral neuropathy in diabetic rats. Experimental diabetes was induced by single intraperitoneal injections of nicotinamide (50 mg/kg) and streptozotocin (52.5 mg/kg). Rats were allocated into five groups. Two groups were given saline or liraglutide (0.8 mg/kg, s.c.). Three diabetic groups were either untreated or treated with liraglutide (0.8 mg/kg, s.c.) or pregabalin (10 mg/kg, i.p.). After 2 weeks of treatment, behavioral, biochemical, histopathological, and immunohistochemical investigations were performed. Treatment with liraglutide‐restored animals’ body weight, normalized blood glucose, decreased glycated hemoglobin, and increased insulin levels. In parallel, it normalized motor coordination and the latency withdrawal time of both tail flick and hind paw cold allodynia tests and reversed histopathological alterations. Treatment with liraglutide also normalized malondialdehyde, matrix metalloproteinase‐2 and ‐9 contents in sciatic nerve. Likewise, it decreased sciatic nerve nitric oxide and interleukin‐6 contents, DNA fragmentation and expression of cyclooxygenase‐2. Meanwhile, it increased superoxide dismutase and interleukin‐10 contents in sciatic nerve. These findings indicate the neuroprotective effect of liraglutide against diabetic peripheral neuropathy probably via modulating oxidative stress, inflammation, and extracellular matrix remodeling.
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DOES ICT GENERATE ECONOMIC GROWTH? A META‐REGRESSION ANALYSIS
Authors: Stanley T. D. , Doucouliagos Hristos , Steel Piers 
Published: March 2018

AbstractDespite phenomenal technological progress and exponential growth in computing power, economic growth remains comparative sluggish. In this paper, we investigate two core issues: (1) is there really no connection between ICT and national economic growth? and (2) what factors moderate the ICT–growth relationship? We apply meta‐regression analysis to 466 estimates drawn from 59 econometric studies that explore the Solow or Productivity Paradox that there is little impact of ICT on economic growth and productivity. We explore the differential impact of ICT on developed and developing countries and the differential impact of different types of ICT: landlines, cell phones, computer technology and Internet access. After accommodating potential econometric misspecification bias and publication selection bias, we detect evidence that ICT has indeed contributed positively to economic growth, at least on average. Both developed and developing countries benefit from landline and cell technologies, with cell technologies’ growth effect approximately twice as strong as landlines. However, developed countries gain significantly more from computing than do developing countries. In contrast, we find little evidence that the Internet has had a positive impact on growth.
Psychosocial safety climate as a moderator of the moderators: Contextualizing JDR models and emotional demands effects
Authors: Loh May Young , Idris Mohd Awang , Dollard Maureen F. , Isahak Marzuki 
Published: March 2018

Psychosocial safety climate (PSC) is a facet‐specific aspect of organizational climate that pertains to employees’ psychological health. We sought to deepen our understanding of how and when resources function by considering the role of PSC as a contextual factor for job demands‐resources model. We explained this using two different mechanisms – PSC as a resource passageway (i.e., channelling, supplying, bolstering, complementing, compensating resources) or PSC as a safety signal (i.e., enabling resource use) effect. Using longitudinal data from 429 Malaysian health care workers from 53 teams and hierarchical linear modelling (HLM), we found team PSC was a stronger moderator of emotional demands than control or rewards on psychological health problems (emotional exhaustion and somatic symptoms), after controlling for the baseline outcomes. A three‐way interaction of team PSC at Time 1 with demands and resources (rewards only) at Time 2 showed that PSC is able to moderate the moderation relationship of demands and resources. Specifically, PSC, as a resource passageway, is providing a range of resources, that likely to compensate and complement low rewards. Hence, when both PSC and rewards were low, emotional demands had the strongest effect on psychological health. This result is robust as it was validated using HLM and split samples of PSC at the upper level. Given the important contextual role of PSC as a ‘moderator of the moderators’, building PSC should be the focus of workplace interventions to protect the psychological health of workers.Practitioner points

Psychosocial safety climate may compensate for job resources, particularly rewards in an organization to protect workers’ psychological health.

Psychosocial safety climate buffers the detrimental effect of emotional demands on workers’ psychological health better than rewards and control.
Determination of the occlusal vertical dimension in edentulous patients using lateral cephalograms
Authors: Enkling N. , Enkling‐Scholl J. , Albrecht D. , Bornstein M. M. , Schimmel M. 
Published: March 2018

SummaryThe determination of the occlusal vertical dimension (OVD) in edentulous patients is based on clinical assessment with high variability. This study tested the hypothesis: The average OVD in edentulous patients with conventional dentures is too low compared to orthodontic norms, when only clinical parameters are used for the determination of the OVD. Edentulous patients with conventional full dentures were enrolled. Clinical parameters were judged by two senior prosthodontists. Digital lateral cephalograms were taken and served to calculate the OVD according to the lower face height angle (ANS‐Xi‐D) taking tooth‐independent facial growth patterns into account. The ANS‐Xi‐D angle was compared with reference values by applying one‐sample mean comparison tests. Thirty‐six participants (17 female, 19 male; mean age 65.3 ± 10.6 years) were enrolled in this study. Clinically, the OVD of four dentures was judged too low, in one case too high, and in the other 31 cases as correct. The mean ANS‐Xi‐D angle was 48.28°±4.86 and statistically not different to the norm value of 49°±4 (n.s.). There was a tendency that the ANS‐Xi‐D angle was different between participants with different tooth‐independent facial growth patterns (ANOVA, P = .0548). Predominantly, clinically sufficient prostheses show adequate ANS‐Xi‐D angles. Short‐face type denture patients are often restored to comply with mesiofacial norms. The determination of the OVD based on lateral cephalography is not recommendable to be a standard diagnostic parameter. Orthodontic norms are derived from dentate cohorts and might not take the continuing facial growth and other confounding factors of edentulous subjects into account.
Effect of Alkaline Peroxides on the Surface of Cobalt Chrome Alloy: An In Vitro Study
Authors: Vasconcelos Glenda Lara Lopes , Curylofo Patricia Almeida , Raile Priscilla Neves , Macedo Ana Paula , Paranhos Helena Freitas Oliveira , Pagnano Valeria Oliveira 
Published: March 2018

AbstractPurposeRemovable denture hygiene care is very important for the longevity of the rehabilitation treatment; however, it is necessary to analyze the effects that denture cleansers can cause on the surfaces of prostheses. Thus, this study evaluated the effect of alkaline peroxide‐effervescent tablets on the surface of cobalt‐chromium alloys (Co‐Cr) used in removable partial dentures.Materials and MethodsCircular metallic specimens (12 × 3 mm) were fabricated and were immersed (n = 16) in: control, Polident 3 Minute (P3M), Steradent (S), Efferdent (E), Polident for Partials (PFP), and Corega Tabs (CT). The surface roughness (μm) (n = 10) was measured before and after periods of cleanser immersion corresponding to 0.5, 1, 2, 3, 4, and 5 years. Ion release was analyzed (n = 5) for Co, Cr, and molybdenum (Mo). Scanning electron microscopy (SEM) analysis and an Energy‐dispersive X‐ray spectroscopy (EDS) were conducted in one specimen. The surface roughness data were statistically analyzed (α = 0.05) with the Kruskal‐Wallis test to compare the solutions, and the Friedman test compared the immersion durations. Ion release analysis was performed using 2‐way ANOVA and Tukey's test.ResultsThere was no significant surface roughness difference when comparing the solutions (p > 0.05) and the immersion durations (p = 0.137). Regarding ion release (μg/L), CT, E, and control produced a greater release of Co ions than S (p < 0.05). CT produced a greater release of Cr ions than control, S, and P3M (p < 0.05). Finally, E caused the greatest release of Mo ions (p < 0.05). SEM confirmed that the solutions did not damage the surfaces and EDS confirmed that there were no signs of oxidation.ConclusionThe various solutions tested did not have any deleterious effects on the Co‐Cr alloy surface. Steradent, however, presented the smallest ionic release.
Rehabilitation of Edentulism and Mortality: A Systematic Review
Authors: Gupta Avni , Felton David A. , Jemt Torsten , Koka Sreenivas 
Published: March 2018

AbstractPurposeIt has been shown that tooth loss is associated with an increased risk of early mortality, and that prosthetic rehabilitation of edentulism improves quality of life and reduces morbidity. This review examines association between prosthetic rehabilitation of the edentulous state with a complete denture and mortality.MethodsA systematic search using combinations of related keywords for “complete denture” and “mortality” was performed on PubMed, Web of Science, and Google Scholar. A reference search of included articles and author contacts was also performed.ResultsNone of the studies reported results for association between mortality and wearing complete dentures among edentulous individuals; however, based on the published methods and results, a total of 15 studies were found to be eligible for author contacts to obtain relevant data. Overall, 5 eligible studies were included and critically evaluated to summarize their findings. The follow‐up period in these studies ranged from 3 to 24 years, and the age group of included samples ranging from 52 to 105 years. The proportion of individuals not wearing dentures ranged from 3.0% to 13.3%. Four of the included studies showed fewer individuals without complete dentures surviving over the follow‐up years as compared to the group wearing complete dentures. One of two studies that could adjust for certain confounders found no significant difference in mortality after adjusting, but another study found a 42% reduced risk of dying among those wearing complete dentures, as compared to those not wearing complete dentures after adjusting for age, sex, educational level, smoking, alcohol drinking, body mass index, time spent walking daily, medical history, psychological distress score, energy intake, and protein intake. Due to the small sample size of nondenture wearers, it was not possible to analyze with statistical rigor the comparative risk of dying associated with wearing or not wearing complete dentures.ConclusionMost of the included studies indicated a higher proportion of deceased edentulous patients not using dentures as compared to denture wearers. Nevertheless, small sample size prevents a definite conclusion being drawn regarding a relationship between prosthetic rehabilitation and mortality among edentulous individuals.
Sensory characterization of Nile tilapia croquettes enriched with flaxseed flour using free‐choice profiling and common components and specific weights analysis
Authors: Fuchs Renata H. B. , Ribeiro Ricardo P. , Bona Evandro , Kitzberger Cíntia S. G. , de Souza Carolina , Matsushita Makoto 
Published: March 2018

AbstractThis research described sensory characteristics of freeze‐dried mixtures of tilapia croquettes enriched with flaxseed flour using free‐choice profiling (FCP) and analyzed the data through the common components and specific weights analysis (CCSWA). Enriched croquette was defined by brown color, odor and taste of flour, and creaminess. Control croquette was defined by odor and taste of fish, odor and spicy flavor, and frying flavor. CCSWA captured 92.1% of the variance with the first two common components (CC). CC1 (82.8% of the variance) was able to correctly discriminate the products, while CC2 (9.3% of the variance) separates the repetition of the same product. Furthermore, CCSWA allows a differentiated analysis of the importance of the judges, proving to be a good alternative to statistical analysis for FCP.Practical applicationsFree‐choice profile (FCP) technique is a descriptive sensory method that has as main advantage the elimination of the training phase of the panelists, which makes it faster and more advantageous. Traditionally, the results from these methods are analyzed through generalized procrustes analysis (GPA). In this work, the results of the sensory description of tilapia croquettes enriched with flaxseed flour were analyzed through common components and specific weights analysis (CCSWA). Despite presenting various sensory differences, the addition of flaxseed flour to the product is viable, since it improves the fatty acid composition. The CCSWA enables a differentiated analysis of each judges, proving to be a method that allows a more detailed analysis of the results obtained by the FCP.
Effects of oxidative stress induced by high dosage of dietary iron ingested on intestinal damage and caecal microbiota in Chinese Yellow broilers
Authors: Gou Z. Y. , Li L. , Fan Q. L. , Lin X. J. , Jiang Z. Y. , Zheng C. T. , Ding F. Y. , Jiang S. Q. 
Published: March 2018

SummaryThe objective of this trial was to test the effects of oxidative stress induced by a high dosage of dietary iron on intestinal lesion and the microbiological compositions in caecum in Chinese Yellow broilers. A total of 450 1‐day‐old male chicks were randomly allotted into three groups. Supplemental iron (0, 700 and 1,400 mg/kg) was added to the basal diet resulting in three treatments containing 245, 908 and 1,651 mg/kg Fe (measured value) in diet respectively. Each treatment consisted of six replicate pens with 25 birds per pen. Jejunal enterocyte ultrastructure was observed by transmission electron microscopy. The results showed that a high dosage of dietary iron induced oxidative stress in broilers. Dilated endoplasmic reticulum (ER), autophagosome formation of jejunal enterocytes and decreased villi were caused by this oxidative stress. Compared to the control, concentration of the malondialdehyde (MDA) in jejunal mucosa in the 908 and 1,651 mg/kg Fe groups increased by 180% (p < .01) and 155% respectively (p < .01); activity of copper‐zinc superoxide dismutase (Cu/ZnSOD) increased in jejunum (p < .01); and the concentration of plasma reduced glutathione (GSH) decreased by 34.9% (p < .01) in birds fed 1,651 mg/kg Fe. Gene expression of nuclear factor, erythroid‐derived 2‐like 2 (Nrf2) and zonula occludens‐1 (ZO‐1), in the higher dietary Fe groups was enhanced (p < .05). Species of microbial flora in caecum increased caused by oxidative stress. The PCR‐DGGE (denaturing gradient gel electrophoresis) dendrograms revealed different microbiota (65% similarity coefficient) between the control and iron‐supplemented groups (p < .05). These data suggest high dosage of iron supplement in feed diet can induce oxidative stress in Chinese Yellow broilers, and composition of microbiota in the caecum changed. It implied there should be no addition of excess iron when formulating diets in Chinese Yellow broilers.
A detailed study of leaf micromorphology and anatomy of New World Vitis L. subgenus Vitis within a phylogenetic and ecological framework reveals evolutionary convergence
Authors: Ickert‐Bond Stefanie M. , Harris AJ , Lutz Sue , Wen Jun 
Published: March 2018

AbstractWe investigated leaf anatomy and micromorphology in the New World Vitis using light and scanning electron microscopy to understand the correlation of these traits to molecular phylogenetic relationships and environmental affinity. We observed traits known to differ among species of Vitis with importance in traditional taxonomy of Vitis: trichome type, stomata morphology, mesophyll organization, and midrib vascularization. We found that traits associated with water conductance and photosynthesis comprised the highest loadings of axis one of a principal components analysis (PCA) while traits related to gas exchange (i.e., the stomatal apparatus) had high loadings on axis two. Using the PCA, we identified seven clusters of species, which showed little correlation to recently reported molecular phylogenetic relationships. Moreover, analyses using Bayes Traits and Bayesian Binary Method revealed little to no phylogenetic signal in trait evolution. PCA axes one and two separated species occurring in dry southwestern North American habitats from those in mesic places. For example, a cluster of V. monticola and V. arizonica occurred adjacent to a cluster of V. californica and V. girdiana in ordination space, and the latter three species share key leaf anatomical traits. Nevertheless, among these, only V. arizonica and V. girdiana are closely related according to molecular phylogeny. Thus, the leaf micromorphological/anatomical traits of Vitis observed in this study are highly correlated with environment, but not phylogenetic relationships. We expect that trait similarities among distantly related species may result from evolutionary convergences, especially within xeric habitats of western North America.
Barriers to and enablers of implementing antimicrobial stewardship programs in veterinary practices
Authors: Hardefeldt Laura Y. , Gilkerson J. R. , Billman‐Jacobe H. , Stevenson M. A. , Thursky K. , Bailey K. E. , Browning G. F. 
Published: March 2018

BackgroundAntimicrobial stewardship (AMS) programs are yet to be widely implemented in veterinary practice and medical programs are unlikely to be directly applicable to veterinary settings.ObjectiveTo gain an in‐depth understanding of the factors that influence effective AMS in veterinary practices in Australia.MethodsA concurrent explanatory mixed methods design was used. The quantitative phase of the study consisted of an online questionnaire to assess veterinarians’ attitudes to antimicrobial resistance (AMR) and antimicrobial use in animals, and the extent to which AMS currently is implemented (knowingly or unknowingly). The qualitative phase used semi‐structured interviews to gain an understanding of the barriers to and enablers of AMS in veterinary practices. Data were collected and entered into NVivo v.11, openly coded and analyzed according to mixed methods data analysis principles.ResultsCompanion animal, equine, and bovine veterinarians participated in the study. Veterinary practices rarely had antimicrobial prescribing policies. The key barriers were a lack of AMS governance structures, client expectations and competition between practices, cost of microbiological testing, and lack of access to education, training and AMS resources. The enablers were concern for the role of veterinary antimicrobial use in development of AMR in humans, a sense of pride in the service provided, and preparedness to change prescribing practices.Conclusion and Clinical ImportanceOur study can guide development and establishment of AMS programs in veterinary practices by defining the major issues that influence the prescribing behavior of veterinarians.
Prospective long‐term evaluation of parenteral hydroxocobalamin supplementation in juvenile beagles with selective intestinal cobalamin malabsorption (Imerslund‐Gräsbeck syndrome)
Authors: Kook Peter Hendrik , Reusch C. E. , Hersberger M. 
Published: March 2018

BackgroundProspective studies on maintenance treatment for Beagles with hereditary selective cobalamin (Cbl) malabsorption (Imerslund‐Gräsbeck syndrome, IGS) are lacking. In our experience, measurement of methylmalonic acid (MMA), a Cbl‐dependent metabolite, seems more helpful to monitor Cbl status as compared with serum Cbl concentrations.ObjectivesTo evaluate a standardized Cbl supplementation scheme in Beagles with IGS. We hypothesized that a single parenteral dose of 1 mg hydroxocobalamin (OH‐Cbl) would maintain clinical and metabolic remission for up to 2 months.AnimalsSix client‐owned juvenile Beagles with genetically confirmed IGS and 28 healthy control dogs.MethodsProspective study. Monthly IM OH‐Cbl (1 mg) supplementation was done over a median of 9 months (range, 6‐13) in 6 dogs, followed by bimonthly (every 2 months) injections in 5 dogs over a median of 6 months (range, 3‐10). Health status was assessed by routine clinical examinations at injection time points and owner observations. Voided urine samples were collected immediately before OH‐Cbl injections for measurement of MMA‐to‐creatinine concentrations using a gas‐liquid chromatography‐tandem mass spectrometry (GC‐MS) method.ResultsAll dogs were clinically healthy while receiving monthly and bimonthly OH‐Cbl supplementation. Urinary MMA results in healthy dogs ranged from 1.3 to 76.5 mmol/mol creatinine (median, 2.9). Median urinary MMA concentrations did not differ between dogs with IGS receiving monthly (n = 49; 5.3 mmol/mol creatinine; range, 2.3‐50.4) and bimonthly (n = 31; 5.3 mmol/mol creatinine; range, 1.6‐50) injections.Conclusions and Clinical ImportanceA maintenance parenteral dose of 1 mg OH‐Cbl monthly or bimonthly appears adequate in Beagles with IGS monitored by metabolic testing.