bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of the first bacteriocin isolated in Lebanon extracted via a modified adsorption-desorption method and its potential food application
Authors: Al Kassaa Imad , ZAYLAA Mazen , Hussein Samah , El Omari Khaled , Chihib Nour-Eddin , Hamze Monzer , Yusef Hoda , Dabboussi Fouad 
Published: March 2018

Introduction: The raw goat milk is considered as a good source of novel bacteriocinogenic lactic acid bacteria (LAB) strains.
Method: The bacteriocin, which named enterocin CMUL20-2 was secreted by Enterococcus faecium CMUL20-2. This bacterial strain was originally isolated from raw goat’s milk, was extracted by using a modified adsorption-desorption method and purified via RP-HPLC. antimicrobial activity was tested against several pathogenic and spoilage microbes.
Results: The enterocin CMUL20-2 showed a strong adsorption on cell wall of producer strain even in acidic environment which facilitate its extraction in only two simple steps. The recovered purified enterocin has decreased procedure time and diminished the number of undesirable molecules present in Rogosa and Sharpe (MRS) broth. The recovered enterocin showed antimicrobial activity against several foodborne pathogenic and spoilage microbes.
Conclusion: The recovered enterocin was able to tolerate a variety of food chain conditions such as high temperature, pH and storage stability, and it can be a good candidate to protect food from spoilage microbes
Laboratory Simulations of Haze Formation in the Atmospheres of Super-Earths and Mini-Neptunes: Particle Color and Size Distribution
Authors: He Chao , Hörst Sarah M. , Lewis Nikole K. , Yu Xinting , Moses Julianne I. , Kempton Eliza M.-R. , McGuiggan Patricia , Morley Caroline V. , Valenti Jeff A. , Vuitton Véronique 
Published: March 2018

Abstract
Super-Earths and mini-Neptunes are the most abundant types of planets among the ∼3500 confirmed exoplanets, and are expected to exhibit a wide variety of atmospheric compositions. Recent transmission spectra of super-Earths and mini-Neptunes have demonstrated the possibility that exoplanets have haze/cloud layers at high altitudes in their atmospheres. However, the compositions, size distributions, and optical properties of these particles in exoplanet atmospheres are poorly understood. Here, we present the results of experimental laboratory investigations of photochemical haze formation within a range of planetary atmospheric conditions, as well as observations of the color and size of produced haze particles. We find that atmospheric temperature and metallicity strongly affect particle color and size, thus altering the particles’ optical properties (e.g., absorptivity, scattering, etc.); on a larger scale, this affects the atmospheric and surface temperature of the exoplanets, and their potential habitability. Our results provide constraints on haze formation and particle properties that can serve as critical inputs for exoplanet atmosphere modeling, and guide future observations of super-Earths and mini-Neptunes with the Transiting Exoplanet Survey Satellite, the James Webb Space Telescope, and the Wide-Field Infrared Survey Telescope.
ALMA Detections of CO Emission in the Most Luminous, Heavily Dust-obscured Quasars at z > 3
Authors: Fan 范 Lulu 璐璐 , Knudsen Kirsten K. , Fogasy Judit , Drouart Guillaume 
Published: March 2018

Abstract
We report the results of a pilot study of CO(4 − 3) emission line of three Wide-field Infrared Survey Explorer (WISE)-selected hyper-luminous, dust-obscured quasars (QSOs) with sensitive ALMA Band 3 observations. These obscured QSOs with L
bol > 1014
L
⊙ are among the most luminous objects in the universe. All three QSO hosts are clearly detected both in continuum and in CO(4 − 3) emission line. Based on CO(4 − 3) emission line detection, we derive the molecular gas masses (∼1010−11
M
⊙), suggesting that these QSOs are gas-rich systems. We find that the obscured QSOs in our sample follow the similar

relation as unobscured QSOs at high redshifts. We also find the complex velocity structures of CO(4 − 3) emission line, which provide the possible evidence for a gas-rich merger in W0149+2350 and possible molecular outflow in W0220+0137 and W0410−0913. Massive molecular outflow can blow away the obscured interstellar medium and make obscured QSOs evolve toward the UV/optical bright, unobscured phase. Our result is consistent with the popular active galactic nucleus (AGN) feedback scenario involving the co-evolution between the supermassive black holes and host galaxy.
High-Definition Optical Coherence Tomography of the Macula in Deprivational Amblyopia
Authors: Al-Haddad Christiane , Mehanna Carl-Joe , Ismail Karine 
Published: March 2018

BACKGROUND AND OBJECTIVE:
This study evaluated macular thickness in deprivational amblyopia and compared it to matched controls.

PATIENTS AND METHODS:
The authors present a cross-sectional study of patients with amblyopia from pediatric cataract and matched controls. Macular high-definition optical coherence tomography scans of each eye were acquired. Central macular thickness (CMT) and parafoveal thicknesses at 500 μm, 1,000 μm, and 1,500 μm in the nasal, temporal, inferior, and superior locations were measured.

RESULTS:

Thirty-four eyes were included: 14 eyes with deprivational amblyopia and 20 controls. In amblyopes, the mean age was 10.06 years ± 3.89 years and logMAR visual acuity (VA) was 0.41 ± 0.53, whereas in the control group, mean age was 8.96 years ± 1.89 years and mean logMAR VA was 0.03 ± 0.05. The macula in deprivational amblyopia was significantly thicker centrally compared to controls (
P
= .0013), but only tended to be thicker at 500 μm and thinner at 1,000 μm and 1,500 μm. Male gender, poorer VA, and hyperopic refraction positively correlated with CMT (
P
= .011,
P
= .018, and
P
= .038, respectively).

CONCLUSION:
Eyes with deprivational amblyopia had increased CMT compared to controls, and this correlated with the severity of amblyopia.

[
Ophthalmic Surg Lasers Imaging Retina
. 2018;49:198–204.]
An Isolated TCR αβ Restricted by HLA-A*02:01/CT37 Peptide Redirecting CD8+ T Cells To Kill and Secrete IFN-γ in Response to Lung Adenocarcinoma Cell Lines
Authors: Flores-Villanueva Pedro O. , Ganachari Malathesha , Guio Heinner , Mejia Jaime A. , Granados Julio 
Published: March 2018

Abstract
Lung cancer is a leading cause of cancer-related death among both men and women in the United States, where non–small cell lung cancer accounts for ∼85% of lung cancer. Lung adenocarcinoma (ADC) is the major histologic subtype. The presence of actionable mutations prompts the use of therapies designed to specifically address the deleterious effects of those cancer-driving mutations; these therapies have already shown promise in cases carrying those actionable mutations (∼30%). Innovative therapeutic approaches are needed for the treatment of 70% of patients suffering from lung ADC. Adoptive transfer of CD8+ T cells specific against cancer/testis (CT) Ags, whose protein expression is restricted to the gonads (testis and ovary) and cancerous cells, is an excellent alternative. In this study, we report the isolation of HLA-A*02:01/CT37 peptide–specific α and β TCR chains from a CD8+ T cell clone obtained from a patient suffering from lung ADC. We also report the development of an innovative CD3ζ construct. With those TCR chains and the engineered (modified) CD3ζ chain, we produced a construct that when transduced into CD8+ T cells is capable of redirecting transduced CD8+ T cell cytotoxic activity and IFN-γ secretion against peptide-pulsed autologous cells and HLA-A*02:01–positive and CT37-expressing lung ADC cell lines. Our findings will launch the development of innovative adoptive transfer immunotherapies for the treatment of lung ADC, targeting the most prevalent HLA molecules and CT37 peptides restricted by these molecules.
Arcite's Overheard Song: The Knight's Tale and the Prosimetrum Tristan en prose
Authors: Matthews Ricardo 
Published: March 2018

Abstract
The medieval prosimetrum challenges many prevalent theories of the lyric because of the way it seems to personalize highly conventional and anonymous songs when placed within the context of a narrative frame. The article analyzes a tradition of knights listening to other knights complaining in song of their resistant loves. Palamoun's violent reaction to Arcite's rondeau in the Knight's Tale repeats a pattern found frequently in the Arthurian prosimetrum Tristan en prose: a knight stops in the woods, overhears another knight's song, and then endeavors to interpret the lyric's oblique references to the dame, often with violent consequences. For both Palamoun and Tristan, the referential nature of framed songs becomes a problem, especially when that overheard song could potentially be about one's lady.
A Language for Ethics and Eloquence: Political and Linguistic Order in Chaucer's Lak of Stedfastnesse
Authors: Crosson Chad G. 
Published: March 2018

Abstract
Lak of Stedfastnesse exemplifies the shift prior criticism took from a strictly humanist perspective on Chaucer's work, wherein he eschewed politics, to an understanding of his poetry wherein political references and concerns abound. Reading this poem in light of both the mirror-for-princes genre and traditions of grammatical instruction, the article shows how Chaucer interweaves the concerns of a timebound, contingent, political world with those of the timeless, absolute world of moral values. Through a negotiation between these two worlds, Chaucer suggests how poetry might intervene in ethical practice. Lak of Stedfastnesse reveals how the political becomes a means rather than an end. Neither political nor apolitical, Chaucer forges a middle way to explore the potentialities of language and literature.
A Proposal to Adopt Data Discrimination Rather than Privacy as the Justification for Rolling Back Data Surveillance
Authors: Cramer Benjamin W. 
Published: March 2018

Abstract
Critics of data surveillance by government and businesses have used a legal strategy based on privacy, but have thus far been unsuccessful. This article suggests that civil libertarians should consider raising the specter of unfair data discrimination in legal arguments to roll back data surveillance, and they may find support from statutory and judicial precedents in which the American government fought to protect citizens from older types of discrimination. This may in turn support arguments that America is traditionally opposed to discrimination, and should be opposed to modern discrimination caused by data surveillance practices.
From Fairy Host to Mutant Community: The “Singular” Changeling in Folklore, Medical Discourse, and Theories of Evolutionary Change
Authors: Lawrence Adam 
Published: March 2018

ABSTRACT
The socially and biologically diverse “Fairyland” we find in legends represented to those who believed in supernatural agency both an alternative model for social relations and a metaphor for the unpredictable nature of life, including sudden physical transformation. The changeling legend—in which a healthy human is exchanged for a malformed fairy—played a significant role not only in traditional “diagnoses” for congenital malformation but also in contemplating evolutionary change. Science-fiction authors like Theodore Sturgeon, Poul Anderson, Paul McAuley, and Harlan Ellison appear to have adapted the legend to reimagine the versatile folkloric changeling as a potential model in a technologically advanced environment, where sympathy and hospitality are often pushed to the wayside. In highlighting humanity's changeling status, these authors encourage us to reverence those earth-dwelling denizens that possibly gave us our ethos in the first place.
Ocupación social del espacio en el Estado de Tlaxcala, México, 1980-2017
Authors: Martínez Rodríguez María Concepción , Reynoso Pérez Rolando , Alvarado Cardona Miguel , Romero Javier 
Published: March 2018

Actualmente, el estado de Tlaxcala enfrenta grandes desafíos en materia de ordenamiento territorial y gestión urbana, pues desde el último tercio del siglo pasado ha experimentado un rápido incremento demográfico en las localidades rurales que conforman a la periferia de sus ciudades, lo que se traduce en una rápida urbanización del estado, pero también en grandes retos para afrontar esta transición demográfica.
Este estudio pretende explicar el proceso de urbanización de la zona metropolitana del estado entre 1980 y 2017, utilizando la información estadística disponible y fundamentándose en diversas teorías de desarrollo urbano, con el objetivo de realizar una caracterización del sistema territorial con la información existente, e incorporar el análisis de las diferentes interacciones de los sistemas naturales, sociales, económicos y jurídicos que influyen en la dinámica poblacional de Tlaxcala, para posteriormente, hacer un diagnóstico del estado e identificar las principales debilidades del modelo de desarrollo urbano actual. Finalmente, se realiza una propuesta para orientar el ordenamiento territorial del estado, que aterrice en las necesidades concretas de infraestructura, servicios y estrategias de desarrollo requeridas para lograr una integración eficiente, ordenada y sustentable de las localidades rurales a la región metropolitana de Tlaxcala.
Paridad de género en los debates políticos argentinos
Authors: Cano Micaela Soledad , Cano Julieta Evangelina 
Published: March 2018

Recientemente en la provincia de Buenos Aires se aprobó la ley de paridad de género en las listas electorales, no sin acalorados debates acerca de la necesidad de la ley, como así también de la justicia o injusticia que la sanción de la misma representa.
Con motivo de la sanción de dicha ley y el debate que generó a nivel nacional, nos proponemos sistematizar los argumentos a favor y en contra de los derechos políticos de las mujeres en Argentina. Para acercarnos a nuestro objetivo usaremos como fuente principal las versiones taquigráficas de los debates parlamentarios en ocasión ley de paridad bonaerense de 2016. Por su novedad en nuestro país, esta ley reactivó discursos contrarios a la participación femenina que ya creíamos superados. Este trabajo busca identificar los argumentos que evidencian resistencias a la participación política de las mujeres, y cómo estos argumentos son reediciones de antiguos argumentos, ya vertidos en el recinto parlamentario cada vez que este tema logró ingresar a la agenda política.
Consideramos también importante contextualizar el momento actual y, en pos de construir conocimiento situado, realizamos un breve recorrido histórico sobre la participación política de las mujeres en Argentina. Nuestra intención es identificar los discursos en juego, constructores de la ciudadanía femenina.
Presentación del director
Authors: Garretón Manuel Antonio 
Published: March 2018

La Revista de Sociología nació en 1986, hace poco más de treinta años y, debido a las circunstancias tanto del contexto histórico nacional como del desarrollo de las Ciencias Sociales, ha pasado por varias etapas. Hoy se
cierra una de ellas, en la que la dirección estuvo a cargo de Octavio Avendaño, quien junto a su equipo editorial, los colaboradores y autores, cumplió una enorme labor en entregarle a la Revista una prestancia científica y a la vez una presencia en los debates intelectuales de nuestro país. Este es el desafío principal que tiene una Revista de Sociología: estar a la altura de los más altos estándares disciplinarios y transdisciplinarios y al mismo tiempo estar presente en el debate intelectual sobre nuestra sociedad.
Dialectical Logic K-model: On Multidimensional Discrete Dynamical Sampling System and Further Properties of Kirchhoff Matrices
Authors: Jiang Yaozhi 
Published: March 2018

In order to solve the problem of multidimensional logic variable true value function remarked in the paper(Yaozhi Jiang., 2017), now author has used discrete multiple Fourier transform to deal with the problem remarked above, and obtained an theoretical formulations of discrete multidimensional Fourier transform for that multidimensional logic variable true value function is unknown or we need the frequency properties of multidimensional logic variable true value function. Another problem is about further and deeper properties of Kirchhoff matrices defined in author’s paper(Yaozhi Jiang., 2017), author has established a series of matrix expression for Kirchhoff laws and some new properties of Kirchhoff matrices. These results are all compute-able and complicated.
Innovative finance to deliver adequate marine biodiversity knowledge for high seas and deep ocean governance beyond national jurisdiction.
Authors: Thiele Torsten 
Published: March 2018

Torsten Thiele, Ocean Governance, Institute for Advanced Sustainability Studies, Potsdam, Germany torsten.thiele@iass-potsdam.de
High seas and deep sea governance is progressing through the UN BBNJ process. At the same time the International Seabed Authority is developing a Mining Code for the Area. Both processes are in need of adequate marine biodiversity knowledge to ensure that the governance regimes address adequately the challenges of human impacts on these critical ecosystems. The chosen management structures need to reflect the complexity and connectivity of marine life. They have to be enforceable, practicable and cost-effective. Such solutions will require significant funding, which can be delivered at scale if the financing model chosen is robust and has the right incentives for private sector participation. A well-structured and funded marine biodiversity knowledge infrastructure would have a wide range of benefits beyond the role as a key part of an ocean governance system. It could be base for a broader public-private partnership for ocean regeneration, delivering large-scale science, research and conservation objectives. Innovative finance is a mechanism to put such an effective policy and legal response in place, but needs to be developed and supported in cooperation with the marine science community. This talk will cover ocean policy issues as well as the innovative finance approach.
Analisis Estimasi Biaya Langsung Medis Penderita Rawat Jalan Diabetes Mellitus Tipe 2 di RSUD Dr. Abdul Aziz Singkawang Tahun 2013
Authors: 1976 Mursalin , Soewondo Prastuti 
Published: March 2018

AbstrakDiabetes Mellitus merupakan penyakit epidemik yang menjadi ancaman global. Selain tingkat morbiditas dan mortalitas yang tinggi, juga menyebabkan sebagian besar negara di dunia mengeluarkan anggaran kesehatan yang besar. Penelitian ini bertujuan untuk menghitung besarnya biaya langsung medis dan faktor-faktor yang mempengaruhinya pada penderita rawat jalan diabetes mellitus tipe 2. Penelitian dilaksanakan pada bulan Januari – Februari 2015 di RSUD dr. Abdul Aziz Singkawang, Kalimantan Barat. Jenis penelitian ini adalah kuantitatif analitik dengan menggunakan data sekunder yang dikumpulkan secara retrospektif berdasarkan data tahun 2013 dengan jumlah sampel sebanyak 200. Hasil analisis multivariat, terdapat perbedaan yang signifikan biaya langsung medis pada setiap tipe penatalaksanaan, lama sakit dan komplikasi yang dialami penderita. Upaya promotif dan preventif perlu ditingkatkan untuk mencapai efektivitas dan efisiensi pengobatan dan meningkatkan kualitas hidup penderita. AbstractDiabetes mellitus has epidemic diseases that seriously global threated. Except, hight level of morbidity and mortality, its also caused most countries in the world spend a lot of money for health care. This study purpose to count direct medical costs and factors of influence on type 2 diabetes mellitus outpatient care. This study conduct on January to February 2015 in RSUD dr. Abdul Aziz Singkawang at West Kalimantan. Design study used cuantitative analysis by secondary data that retrospectively collected on 2013 data and number of samples are 200. Result of multivariate analysis, there were significant difference means of direct medical costs of type 2 diabetes mellitus outpatient care on type of care, diseases duration, and complication. Health promotion and prevention on type 2 diabetes mellitus intervention must be increasingly to achieve effective and efficient cost of care and to increase patient’s quality of life.
Analisis Pembiayaan Program Promotif dan Preventif Pemberantasan Demam Berdarah Dengue (DBD) Bersumber Pemerintah di Kota Semarang Tahun 2013-2015
Authors: Kamila Nisa 
Published: March 2018

AbstrakSelama tahun 2010-2014, Kota Semarang selalu termasuk dalam peringkat tiga besar Incidence Rate Deman Berdarah Dengue (DBD) di Provinsi Jawa Tengah. Penelitian ini bertujuan menganalisis pembiayaan program pemberantasan DBD bersumber pemerintah pada tahun 2013-2015 dan kesenjangan sumberdaya. Pendekatan akun biaya kesehatan (health account) digunakan untuk menelusuri pembiayaan menurut sumber, fungsi, dan penyedia layanan. Hasil studi menunjukkan bahwa total belanja program DBD bersumber APBD tahun 2013 adalah Rp. 4.018.927.020,- meningkat sebesar 101% pada tahun 2014 dan meningkat sebesar 218% pada tahun 2015. Belanja terbesar pada program pemberantasan DBD adalah untuk kegiatan surveilans epidemiologi dan pengendalian penyakit menular. Tidak terdapat kesenjangan antara ketersediaan sumber daya (berdasarkan belanja kesehatan program pemberantasan DBD) dengan kebutuhan program (berdasarkan perhitungan kebutuhan metode SPM). Disarankan agar perencanaan program lebih berfokus pada kegiatan promotif dan preventif. AbstractIn 2010–2014, Semarang was involved as the big three city with high incidence rate of dengue in Central Java province. This study aimed to analyze the financing by the local government for Dengue preventive program in 2013-2015, as well as the resources gap.The health account approach was used to analyze spending by source, function, and provider. Total local government spending for dengue in 2013 were IDR 4.018.927.020,- increased by 101% in 2014 and increased by 218% in 2015. The largest expenditure for Dengue Preventive program is epidemiological surveillance and infectious disease control. There was no gap between available resources and requires program according to SPM. The study suggested to improve planning by focusing on the direct activities such as promotive and preventive.
Perbedaan Hasil Pemeriksaan Bioelectric Impedance Analysis antara Status Nutrisi Baik dan Malnutrisi pada Penderita Penyakit Gastrointestinal dan Hati yang Dirawat Inap di RSCM Tahun 2013
Authors: Taufiq Taufiq , Syam Ari Fahrial , Lesmana C Rinaldi , Suwarto Suhendro 
Published: March 2018

Pendahuluan. Bioelectric Impedance Analysis (BIA) mulai banyak digunakan dalam mengevaluasi status nutrisi. Belum ada data penelitian nutrisi di Indonesia yang menggunakan BIA. Penelitian ini dilakukan untuk mengetahui perbedaan rerata hasil pemeriksaan BIA antara status nutrisi baik dan malnutrisi pada penderita penyakit gastrointestinal dan hati yang dirawat inap. Metode. Penelitian potong lintang retrospektif terhadap penderita yang dirawat inap di ruang perawatan interna RSCM periode 1 Juni-31 Desember 2013, untuk mengetahui perbedaan rerata hasil pemeriksaan BIA penderita status nutrisi baik dan malnutrisi pada penyakit gastrointestinal dan hati yang dirawat inap.Hasil. Dari 28 penderita dengan status nutrisi baik, 71,57% laki-laki, dan 21,47% wanita. Dari 28 penderita malnutrisi, 53,60% laki-laki, dan 46,40% wanita. Rerata hasil pemeriksaan BIA antara penderita nutrisi baik dan malnutrisi adalah: lean body mass, 49,5 ± 8,59 v s39,68 ± 6,28kg, p<0,001; body cell mass, 32,19 (20,49-40,95) vs 25,23 (17,83-31,64) kg, p=0,003; total body water, 35,69±1,17 vs 28,58±0,85 kg, p<0,001; dan phase angle 6,18◦(3,73-10,11)◦ vs 3,46◦ (0,40-6,51)◦; , p<0,001. Simpulan. Pada penderita penyakit gastrointestinal dan hati yang dirawat inap dengan status nutrisi baik, memiliki nilai body mass, body cell mass,total body water dan phase angle hasil pemeriksaan BIA yang lebih tinggi dibandingkan dengan penderita malnutrisi.