bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Food and Nutrition Value of Rubus alceifolius Poir. Fruits of Mizoram, India
Authors: Laldinchhana  , Dutta Rajat S. , Thanzami Kawl , Lalhlenmawia Hauzel , Pachuau Lalduhsanga 
Published: May 2019

Background:
Lesser known fruits and vegetables could be the source of dietary antioxidants
and nutrition. However, to establish that these fruits and vegetables are important in healthy diet,
it is imperative that thorough scientific investigations are performed. Results and data from such
studies can also help in framing their conservation policy as well as in their promotion.

Objectives:
The present study reports for the first time the physicochemical properties, functional and
antioxidant activities of the wild berry fruit Rubus alceifolius Poir collected from Mizoram, India.

Methods:
The average size, pH, juice content, the fruit acid content and dry matter content were determined.
The antioxidant components of the fruit extract such as anthocyanin, β-carotene, lycopene,
total phenolic and flavonoid contents were also reported.

Results:
The SPF number of the fruit calculated from Mansur’s equation was found to be 1.59 ± 0.03.
HPLC analysis of the fruit extract for phenolic acids showed the presence of ellagic acid and gallic
acid in the acetone-extract.

Conclusion:
Results from studies on various antioxidant activities such as DPPH scavenging, reducing
capability and inhibition of lipid peroxidation indicate that the R. alceifolius fruit possesses
antioxidant activities and its consumption may help in reducing the oxidative stress and preventing
the various degenerative diseases associated with it.
New Insights into the Binding Mechanism of Co-regulator BUD31 to AR AF2 Site: Structural Determination and Analysis of the Mutation Effect
Authors: Song Tianqing , Li Jiazhong 
Published: May 2019

Introduction:
Androgen Receptor (AR) plays a pivotal role in the development of male
sex and contributes to prostate cancer growth. Different from other nuclear receptors that bind to
the co-regulator LxxLL motif in coregulator peptide interaction, the AR Ligand Binding Domain
(LBD) prefers to bind to the FxxLF motif. BUD31, a novel co-regulator with FxxLF motif, has
been demonstrated to suppress wild-type and mutated AR-mediated prostate cancer growth.

Methods:
To find out the interaction mechanisms of BUD31 with WT/T877A/W741L AR complex,
molecular dynamics simulations were employed to study the complex BUD31 and
WT/mutant ARs. The molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) results
demonstrated that T877A and W741L point mutations can reduce the binding affinity between
BUD31 and AR. The RMSF and dynamic cross-correlation analysis indicated that amino acid point
mutations can affect the motions of loop residues in the AR structure.

Results:
These results indicated that AR co-regulator binding site AF2 can serve as a target for
drug discovery to solve the resistance problem.
When are Firms Sued for Qualitative Disclosures? Implications of the Safe Harbor for Forward-Looking Statements
Authors: Cazier Richard A. , Merkley Kenneth J. , Treu John S. 
Published: May 2019

ABSTRACT
Prior research finds that positive tone in firms' qualitative disclosures increases the risk of shareholder lawsuits. However, federal securities laws provide a safe harbor intended to shield firms' forward-looking statements from legal liability. One implication of this safe harbor is that litigation risk potentially varies between qualitative forward- and non-forward-looking statements. Consistent with this implication, we find that positive tone in forward-looking qualitative statements is significantly less related to the likelihood of subsequent litigation than is positive tone in non-forward-looking qualitative statements. On average, we fail to find a significant association between qualitative forward-looking statements and subsequent litigation. We do find evidence, however, that positive tone in qualitative forward-looking statements relates positively to subsequent litigation in two U.S. circuits in which court rulings reduced safe harbor protections for forward-looking statements. Overall, our results are consistent with the safe harbor effectively shielding firms' qualitative forward-looking statements from litigation risk.
Sell-Side Analysts' Benchmarks
Authors: Kadan Ohad , Madureira Leonardo , Wang Rong , Zach Tzachi 
Published: May 2019

ABSTRACT
Sell-side analysts employ different benchmarks when defining their recommendations. A buy for some brokers means the stock is expected to outperform its industry, while for other brokers, it means the stock is expected to outperform the market or some return threshold. We show that these stated benchmarks have implications for the distribution of recommendations, price reactions to recommendations, and the investment value of recommendations. We conclude that, depending on the question, academics may need to account for the benchmarks when studying analysts' outputs, and investors may find the benchmarks beneficial in interpreting analysts' advice.
JEL Classifications: G10; G24.
The Pedagogical Work of Vieth and GutsMuths
Authors: Virág Irén 
Published: May 2019

Abstract

Introduction:
Philanthropism as it evolved at the end of the 18th century in Germany wanted to break completely with the contemporary methods persisting in education, with the hegemony of classical languages, and with the study of antique authors’ works; instead, it laid emphasis on practical and useful knowledge, on teaching modern languages, on acquiring knowledge based on demonstration, and on an intimate connection to nature. The aim of philanthropist education was to train virtuous citizens who honestly pursue their ordinary profession, in whose training they assigned a central role to physical education.

Purpose:
In our paper, which is a part of our research exploring the appearance of the pedagogical ideas of philanthropism in Hungary, we set out to investigate the question: What was the focus of physical education in the philanthropinums? As a first step in our investigation, we give an overview of the philanthropists’ ideas regarding physical education, then we take a close look at how these ideas were put into practice in two selected institutions, namely among the walls of the philanthropinums in Dessau and Schnepfenthal, by relying on the contemporary works of Gerhard Ulrich Anton Vieth and Johann Christoph Friedrich GutsMuths. Finally, we consider their impact in Hungary.

Methods:
In this study we apply the source analysis as a traditional research method in the history of education.

Conclusions:
The impact of philanthropism on contemporary Hungarian public education, especially in the first half of the 19th century, can be clearly detected, which can be accredited to study trips to Germany and the Hungarian translations of German works. The presence of philanthropism can also be perceived in swimming instruction. Basedow and GutsMuths initiated the instruction of swimming and lifeguarding, and the general institutionalization of swimming instruction. The impact of philanthropists could also be felt in Hungary. Károly (Carl) Csillagh’s textbook on swimming appeared in German in 1841 with the title “Der philantropische Schwimmmeister” (“The Philanthropist Swimming Instructor”). The first book on swimming in Hungarian appeared in 1842.
The Optimal Control of Two Work-Stealing Deques, Moving One After Another in a Shared Memory
Authors: Barkovsky Eugene Aleksandrovich , Lazutina Anna Aleksandrovna , Sokolov Andrew Vladimirovich 
Published: May 2019

In the parallel work-stealing load balancers, each core owns personal buffer of tasks called deque. One end of the deque is used by its owner to add and retrieve tasks, while the second end is used by other cores to steal tasks. In the paper two representation methods of deques are analyzed: partitioned serial cyclic representation of deques (one of the conventional techniques); and the new approach proposed by our team, without partition of shared memory in advance between deques moving one after another in a circle. Previously we analyzed these methods for representing FIFO queues in network applications, where the “One after another” way gave the best result for some values of the system parameters.
Purpose of this research is to construct and analyze models of the process of work with two circular deques located in shared memory, where they movie one after another in a circle. The mathematical model is constructed in the form of a random walk by integer points in the pyramid. The simulation model is constructed using the Monte Carlo method. The used work-stealing strategy is stealing of one element. We propose the mathematical and simulation models of this process and carry out numerical experiments.
Efektivitas model problem based learning ditinjau dari kemampuan pemecahan masalah matematika
Authors: Jana Padrul , Supiati Endah 
Published: May 2019

Penelitian ini bertujuan untuk mengetahui efektivitas model Problem Based Learning dengan pembanding model pembelajaran langsung ditinjau dari kemampuan pemecahan masalah matematika. Penelitian ini dilakukan di SMA Negeri 1 Pajangan dengan mengambil sampel siswa kelas X MIPA 2 sebagai kelas eksperimen dan kelas X MIPA 1 sebagai kelas kontrol. Jenis penelitian ini menggunakan Quasi Eksperiment (eksperimen semu) dengan desain penelitian The Nonequivalent Posttest-Only Control Group Design. Analisis data yang dilakukan yaitu analisis data uji coba soal posttest kemampuan pemecahan masalah matematika, analisis data hasil observasi keterlaksanaan pembelajaran dengan model Problem Based Learning dan model pembelajaran langsung, dan analisis data hasil posttest kemampuan pemecahan masalah matematika yang meliputi uji normalitas dengan menggunakan uji Kolmogorov Smirnov serta uji hipotesis dengan menggunakan uji T dengan taraf signifikansi α = 0,05. Hasil penelitian menunjukkan bahwa kedua kelas dalam keadaan awal yang setimbang. Berdasarkan uji normalitas nilai posttest kemampuan pemecahan masalah matematika pada kelas eksperimen diperoleh nilai sig. 0,057 > α dan pada kelas kontrol diperoleh nilai sig. 0,200 > α, sehingga kedua kelas berdistribusi normal. Berdasarkan uji T nilai posttest kemampuan pemecahan masalah matematika pada kedua kelas diperoleh > , sehingga dapat disimpulkan bahwa model Problem Based Learning lebih efektiv daripada model pembelajaran langsung ditinjau dari kemampuan pemecahan masalah matematika siswa kelas X MIPA SMA Negeri 1 Pajangan Bantul.
TEORI HUMANISTIK DALAM MULTIMEDIA PEMBELAJARAN BILANGAN BULAT
Authors: Jannah Mita Hapsari , Suyoto Suyoto 
Published: May 2019

This study aims to develop elementary V class multimedia based on humanistic theory on integer competencies that is valid, practical, and effective. The development model is a 4D (define, design, development, disseminate) model. In the define stage there are interviews and observations to study the curriculum and the needs of teachers and students. In the design stage, draft I multimedia was designed using Adobe Flash Player. In the development stage, draft I is valid based on questionnaires from media and material expert validators. Furthermore, the results of field notes and student and teacher response questionnaires indicate that draft II is practical. Then drat III was tested by independent t-test which resulted that draft III is effective. Draft III developed into a final product which was then disseminated at the disseminate stage with the delivery of products to teachers, training of teachers, and publications in national journals.
Primera jornada de detección precoz del cáncer de piel, Asocolderma 2011, reporte de la experiencia en Medellín, Colombia
Authors: Velásquez Margarita María , Zuluaga de Cadena Ángela 
Published: May 2019

Con el propósito de proyectar la Dermatología a la población general, conocer algunos aspectos del problema del cáncer de piel e iniciar campañas masivas de educación nacional, Asocolderma inició este programa en Medellín como ciudad piloto.Se presentan los resultados de la primera jornada realizada del 17 al 19 de mayo de 2011, con la participación de las escuelas de dermatología del CES y la Universidad de Antioquia, y otros dermatólogos de la ciudad. De las 2.404 solicitudes telefónicas, se adjudicaron 1.265 citas. A 246 pacientes se les sospecharon lesiones premalignas o malignas, a 149 se les tomó biopsia y a los demás se les sospechó clínicamente queratosis actínicas o nevus atípicos. Se detectaron dos pacientes con melanoma maligno, 14 con carcinoma escamocelular, 59 con carcinoma basocelular y 1 con porocarcinoma. Se obtuvo información importante sobre las prácticas de exposición y protección solar en este grupo de pacientes.
Tendencia de la incidencia y la mortalidad en melanoma maligno en los últimos 60 años y análisis de los datos del Registro Poblacional (sic.) de Cáncer de Cali
Authors: Oliveros Catalina , Bravo Juan Carlos , Zambrano Ángela , Cepeda Magda , Ramírez Ana Francisca 
Published: May 2019

Introducción. El melanoma maligno cutáneo es uno de los cánceres más agresivos que existen y uno de los de mayor crecimiento global en el mundo. La velocidad con que creció su incidencia después de 1950 ha sido tal, que ha sido considerado por muchos autores como una epidemia que azota a algunos países.Materiales y métodos. Se hizo una búsqueda en Pubmed utilizando los términos MeSH melanoma [AND] trends; de los artículos resultantes, se utilizaron los trabajos originales, teniendo en cuenta para la discusión la incidencia, prevalencia, mortalidad, factores de riesgo, factores socioeconómicos, área corporal, sexo y edad.Resultados y conclusiones. La incidencia del melanoma maligno cutáneo ha aumentado en la mayoría de países. El mayor número de casos y la mayor mortalidad continúan presentándose en hombres, así como las lesiones más avanzadas y de peor pronóstico, en etnias minoritarias y en personas con bajo estrato socioeconómico y pobre acceso a servicios de salud. La mortalidad ha aumentado en la población mayor de 65 años. En Cali, según el análisis del registro de cáncer de Cali, se observa que la incidencia y la mortalidad son más elevadas en hombres y mujeres mayores, con un aumento en la proporción de hombres sobre mujeres.
Prevalencia de herpes, sífilis y condilomatosis en pacientes con VIH en un hospital de referencia de Bogotá
Authors: Motta Adriana , Marín Diana Patricia , Merlo Eliana Andrea 
Published: May 2019

Introducción. La infección por el virus de la inmunodeficiencia humana (VIH) ha afectado a más de 60 millones de personas en el mundo, predisponiéndolas a otras infecciones que aumentan la morbimortalidad. La sífilis, el herpes simple de tipo 2 y los condilomas son coinfecciones frecuentes que modifican el curso del VIH, empeoran el estado de salud de quienes las padecen y conducen a un deterioro rápido que, en ocasiones, puede ser fatal.Objetivo. Determinar la seroprevalencia de infección por herpes simple de tipo 2 y sífilis, y la prevalencia de condilomatosis en los pacientes con VIH/sida en el Hospital Simón Bolívar de Bogotá en el año 2011.Métodos. Se llevó a cabo un estudio descriptivo de corte transversal. La muestra estuvo constituida por 220 pacientes positivos para VIH seleccionados de manera consecutiva en algunos servicios de la institución.Resultados. Se encontró una seroprevalencia de herpes de tipo 2 del 64,9 % y de sífilis de 43,2 %. La prevalencia de condilomatosis fue de 36 %. Conclusiones. Existe una alta prevalencia de sífilis, herpes y condilomatosis en pacientes con VIH, por lo cual se hace necesario desarrollar programas de educación sexual enfocados en la prevención de estas infecciones.
Papel de las quimiocinas en la inmunopatogénesis del linfoma cutáneo de células T
Authors: Mejía María Natalia , Velásquez Margarita María 
Published: May 2019

Los linfomas cutáneos de células T representan una expansión maligna de linfocitos de memoria que muestran una gran predilección por la piel. Son enfermedades de curso largo e indolente que pueden afectar la calidad de vida de forma significativa.Las quimiocinas son una gran familia de citocinas relacionadas con la quimiotaxis, supervivencia y localización celular. Actúan sobre sus células blanco mediante receptores acoplados a proteínas G. En esta revisión se trata el papel que juegan las quimiocinas en el asentamiento de las células tumorales en la piel y su posterior relación con la infiltración de otros órganos; además; sobre cómo ellas son un posible blanco terapéutico para el manejo de estas enfermedades.
Tratamiento quirúrgico y reconstrucción del cáncer periorbitario
Authors: Olmos Miguel , Portilla Nataly , Castro Carlos 
Published: May 2019

Introducción. Se ha estimado que, aproximadamente, 5 a 10 % de todos los cánceres de piel se ubican en la región periorbitaria. El párpado y, en general, la región periorbitaria son sitios anatómicos asociados a un gran riesgo de recurrencia y metástasis. Las recomendaciones sugieren practicar cirugía micrográfica de Mohs y escisión de segmentos por congelamiento.Objetivo. Describir los antecedentes y el contexto actual del tratamiento quirúrgico y la reconstrucción para cáncer periorbital.Métodos. Se hizo una búsqueda en la literatura científica, utilizando las palabras clave (MeSH): neoplasms, carcinoma, squamous cell, basosquamous, melanoma, Mohs surgery, y operadores booleanos. Las bases de datos donde se hizo la búsqueda fueron: Pubmed, Ebsco Host, Embase, Lilacs, Science direct y Ovid.Conclusiones. La cirugía micrográfica de Mohs es actualmente la opción terapéutica y diagnóstica más completa y con menores tasas de recidiva para el tratamiento quirúrgico de tumores cutáneos complejos; además, permite ahorrar tejido sano con la seguridad de la erradicación tumoral. Se sugiere realizar estudios analíticos para establecer una mejor evidencia.
POLITIK HUKUM PERUBAHAN UNDANG-UNDANG NOMOR 17 TAHUN 2014 TENTANG MPR, DPR, DPD DAN DPRD
Authors: Basniwati AD 
Published: May 2019

Demokrasi menekankan pada pentingnya check and balance di seluruh institusi negara. Di Indonesia berjalannya check and balance bisa dilihat dari tidak adanya monopoli wewenang dari sebuah institusi. Namun revisi Undang-undang Nomor 17 tahun 2014 tentang MPR, DPR, DPRD dan DPD (selanjutnya disebut dengan UU MD3) justru kembali meletakkan seluruh kuasa pada tangan eksekutif dan legislatif. Pemanggilan anggota dewan harus seijin presiden dan revisi pada pasal 72 ayat (3) dan (4) mengenai pemanggilan paksa dan penyanderaan yang harus dilakukan atas permintaan DPR tidak mencerminkan komitmen untuk mewujudkan pemerintahan yang adil dan bersih. Pejabat seakan mendapatkan imunitas dari upaya penegakan hukum. Terlepas dari saratnya kepentingan partai politik untuk menguasai DPR, revisi UU MD3 memang sudah selayaknya ditinjau ulang.
DAMPAK PELANGGARAN ASN ATAS SE Menteri PANRB N0. B/2355/M.PANRB/07/2015 DALAM LAYANAN BIROKRASI
Authors: - Syaefullah 
Published: May 2019

The side of the government bureaucracy to the political power or the dominant group makes the bureaucracy not sterile. Many viruses continue to irritate it like; impartial service, far from objectivity, too bureaucratic, etc., as a result they feel stronger themselves, immune from supervision. The descriptions above may be concluded that the neutrality of the bureaucracy will always be associated with political elements and political power; in this case the political element is defined as the power to make decisions, while the political power is all political aggression in the form of political parties.
With the issuance of Law Number 5 of 2014 concerning ASN, in which the law has been regulated and determined in the form of restrictions and sanctions that will be received by a member of the ASN Public Servants and Government Employees with this Work Agreement (PPPK). By looking at the phenomena or opinions above, the writer tries to give a little review of the various impacts that will occur on the roles and functions of civil servants ASN and PPPK if they are not neutral in bureaucratic services as follows: 1. Community interests are distorted, 2 Services are not optimal, 3. Position placement tends to see the involvement in the election, 4. The position of the bureaucracy is filled by incompetent civil servants.
That in order to maintain the neutrality of ASN in the election, it is very necessary:
There is a strengthening of the ASN Code of Ethics with clear and firm limitations, There is a guarantee of protection in maintaining the neutrality of ASN; Collaboration with BKN is established to provide administrative sanctions in the form of not being promoted to ASN, Construction of KASN cooperation, Regional Civil Service Agency (BKN) with Regional Civil Service Agency (BKD) as a source of information in the regions, and Bawaslu to oversee the election and election throughout the Republic of Indonesia. Access to reporting or advocacy on issues of centralization in all parts of Indonesia, as well as guarantees for reporters;
PERAN CIVIL SOCIETY DALAM FILANTROPI ISLAM
Authors: Syahab Abdullah 
Published: May 2019

Runtuhnya orde baru dan masuknya Indonesia ke era reformasi telah memberikan peran besar civil society di Indonesia. Peranan civil society dalam pembangunan negara sangat strategis pada pemerintahan Indonesia yang mengedepankan demokratis dalam pengelolaan negara. Salah satunya dalam pengelolaan zakat di Indonesia. Korupsi, kolusi dan nepotisme pada pemerintahan pada masa reformasi telah mempengaruhi tingkat kepercayaan masyarakat terhadap lembaga pengelola zakat yang dikelola negara. Kebijakan good governance juga telah menumbuhkan pergerakan civil society di Indonesia khususnya dalam memberikan kontribusi bagi perkembangan pengelolaan zakat di Indonesia. Menguatnya peran civil society merupakan realitas sosial kontemporer di Indonesia.
PERANAN TASAWUF DALAM KEHIDUPAN MODERN
Authors: Nilyati Nilyati 
Published: May 2019

Sufisme atau tasawuf merupakan buah peradaban Iaslam yang sangat tua, namun mengalami revitalisasi di era modern ini. Kehadirannya semakin bermakna ketika ia mampu menjadi”oase di padang pasir” bagi masyarakat modern yang pengalami krisis spiritual. Dalam bentuk tarekat tertentu atau dalam bentuk yang sudah termodifikasi, tasawuf menjadi obat penyakit modernisasi dengan segala dampak negatifnya. Tasawuf dengan ajaran kerohanian dan akhlak mulianya semakin memainkan peranan penting. Ia yang dahulu dituduh penyebab kemunduran Islam, dan disikapi secara negatif oleh beberapa pakar Islam, seperti Faslur Rahman dan al-Faruqi, kini makin mendapatkan tempat dalam masyarakat modern. Bahkan ia menjadi solusi yang dinantikan bagi problematika masyarakat modern.
EKSISTENSI PESANTREN DARUU ATTAUHID MUARO KUMPEH - MUARO JAMBI TERHADAP PERUBAHAN SOSIAL KEAGAMAAN MASYARAKAT
Authors: Kusnadi Edi 
Published: May 2019

Penelitian ini mengungkapkan bagaimana eksistensi pesantren Daruu Attauhid di Desa Muaro Kumpeh Kecamatan Kumpeh Ulu Kabupaten Muaro Jambi terhadap perubahan sosial masyarakat sekitar. Adapun yang menjadi permasalahan dalam penelitian ini adalah bagaimana karakteristik pesantren Daruu Attauhid, kemudian bagaimana hubungan pesantren Daruu Attauhid dengan Masyarakat sekitar, dan bagaimana perubahan sosial keagamaan masyarakat sekitar dengan keberadaan pesantren Daruu Attauhid tersebut. Dari hasil pengamatan dan wawancara, didapati informasi bahwa pembelajaran yang dilakukan pada pondok pesantren ini diselenggarakan dengan cara non-klasikal atau dengan klasikal. Adapun bentuk perubahan keadaan sosial keagamaan yang terjadi adalah bahwa keadaan sosial keagamaan menjadi cukup religius.