bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between catastrophizing and altered pain sensitivity in patients with chronic low-back pain
Authors: Meints Samantha M. , Mawla Ishtiaq , Napadow Vitaly , Kong Jian , Gerber Jessica , Chan Suk-Tak , Wasan Ajay D. , Kaptchuk Ted J. , McDonnell Christina , Carriere Junie , Rosen Bruce , Gollub Randy L. , Edwards Robert R. 
Published: December 2018

Abstract
Changes in central pain processing have been shown in patients with chronic low-back pain (cLBP). We used quantitative sensory testing methods to identify differences in pain sensitization between patients with cLBP (N = 167) and healthy controls (N = 33). Results indicated that, compared with healthy pain-free controls, cLBP patients showed increased sensitivity and greater painful aftersensations for mechanical pressure and pin-prick stimuli and lower tactile spatial acuity in the 2-point discrimination task (ps < 0.05). Then, we examined the role of pain catastrophizing as a mediator of the group differences in pain sensitization. We found that catastrophizing partially accounted for group differences in pressure required to produce moderate pain. Finally, we examined the relationship between pain sensitization, catastrophizing, and clinical pain among patients with cLBP. We found that catastrophizing and deep-tissue pressure pain were associated with greater pain intensity in the past month, week, and at the visit as well as low-back pain bothersomeness. Furthermore, deep-tissue pressure pain mediated the associations between catastrophizing and both pain in the past month and low-back pain severity. Taken together, these results indicate that not only do patients with cLBP demonstrate increased pain sensitization and decreased sensitivity to innocuous stimuli, but these changes are also linked with increased catastrophizing. Furthermore, both catastrophizing and sensitization are associated with increased clinical pain among cLBP patients.
Prognostic value of Sirtuin1 in acute ischemic stroke and its correlation with functional outcomes
Authors: Liu Yang , Jia ShiYu , Liang Xue , Dong MeiXue , Xu XiaoMin , Lu ChangQi , Wei YouDong 
Published: December 2018

Abstract

Background:
The blood–brain barrier is impaired in patients with stroke. The release of protein markers such as Sirtuin1 (SIRTl) into circulation may be useful to assess the prognosis of patients with cerebrovascular disease. In this study, we investigated the predictive value of SIRT1 levels in acute ischemic stroke (AIS) patients.

Methods:
In all, 101 AIS patients and 38 healthy controls were enrolled, and blood samples were collected within 72 hours of stroke onset. SIRT1 was analyzed using a commercially available enzyme-linked immunosorbent assay kit. On admission, neurological status was assessed by the standardized National Institutes of Health Stroke Scale (NIHSS). Functional outcomes were measured 1 year after admission using the modified Rankin scale.

Results:
Compared with the control group, SIRT1 was significantly increased in the AIS group (0.63 ± 0.75 vs 0.48 ± 0.80 ng/mL; P ≤ 0.05). However, there was no significant correlation between SIRT1 and NIHSS score at admission (r = −0.01, P = .920). In addition, with an unadjusted odds ratio of 0.862 (95% confidence interval 0.495–1.502), SIRT1 was not significantly correlated with functional outcomes.

Conclusions:
Serum concentrations of SIRT1 have no significant predictive value for favorable functional outcome after acute stroke in our study.
Secondary skin involvement in gastric diffuse large B-cell lymphoma treated with chidamide
Authors: Yang Dan , Zhang Wei-Ping , Yang Jian-Min , He Miao-Xia , Cheng Chao , Chen Jie 
Published: December 2018

Abstract

Rationale:
Diffuse large B-cell lymphoma (DLBCL) is a neoplasm of large B lymphoid cells that exhibits diffuse growth patterns. Patients may present with nodal and/or extranodal disease. The most common extranodal site is the gastrointestinal tract, while skin is less common.

Patient concerns:
We report a case of secondary skin involvement of an original gastric DLBCL, which has achieved a complete response after treatment with chidamide.

Diagnoses:
Initially, the diagnosis of gastric DLBCL is clear, and this patient responded well to systemic chemotherapy (rituximab + cyclophosphamide + epirubicin + vincristine + prednisone) after 8 cycles. Thirty months later, some rapidly enlarging skin nodules on his arm were found. These skin nodules were diagnosed as secondary cutaneous DLBCL based on the clinical features, positron emission tomography-computed tomography, and histomorphologic and immunohistochemical expression.

Interventions:
Steroids, interferon-α, and radiation had little therapeutic effect. We treated the patient with chidamide at 30 mg twice per week in combination with dexamethasone.

Outcomes:
The skin nodules regressed 3 weeks later. During the 1-year follow-up period, the patient is still in treatment with chidamide without adverse reactions.

Lessons:
To the best of our knowledge, this is the first case of secondary skin DLBCL reported to exhibit a complete response to chidamide, which provides a novel therapeutic strategy for secondary skin DLBCL. However, more cases are still needed to further validate its efficacy.
Relationship between oxidative stress and inflammation in hyperuricemia
Authors: Zhou You , Zhao Mingcai , Pu Zheyan , Xu Guoqiang , Li Xiangkun 
Published: December 2018

Abstract
The average age of hyperuricemia patients has gradually decreased, but young patients with primary hyperuricemia often do not exhibit clinical symptoms and have not received sufficient attention. However, a lack of symptoms with primary hyperuricemia does not mean that high serum uric acid (UA) levels cannot lead to pathological effects, such as oxidative stress and inflammation, and the specific damage is still unclear. We aimed to determine the relationship between oxidative stress and inflammation to explore the possible role of pathological damage in asymptomatic young patients with primary hyperuricemia.
A total of 333 participants were enrolled in our study: 158 asymptomatic young patients with primary hyperuricemia and 175 healthy persons from a health check-up population. Malondialdehyde (MDA), superoxide dismutase (SOD), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and general biochemical markers were measured.
We found no differences in biochemical markers (fasting glucose, TG, TC, LDL-C, HDL-C, SCr, BUN, AST, and ALT) between the patients and healthy persons. Subsequent analyses of oxidative stress and inflammation revealed that the serum levels of MDA, IL-6, and TNF-α in the patients were significantly higher than those in the healthy control group (P < .001), and the SOD activity was significantly lower (P < .001). As the UA levels increased, MDA increased significantly and SOD decreased significantly; likewise, IL-6 and TNF-α increased significantly as the UA level increased. MDA showed a significant positive correlation with IL-6 (r = 0.367, P < .001) and TNF-α (r = 0.319, P < .001), and SOD was negatively correlated with IL-6 (r = −0.241, P < .01) and TNF-α (r = −0.308, P < .001). Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698–3.286, P < .001; OR: 3.261, 95% CI: 1.729–3.857, P < .001; for IL-6 and TNF-α, respectively) and MDA (OR: 1.836, 95% CI: 1.283–2.517, P < .01; OR: 2.532, 95% CI: 1.693–3.102, P < .001; for IL-6 and TNF-α, respectively) were risk factors for high IL-6 and TNF-α and that SOD (OR: 0.517, 95% CI: 0.428–0.763, P < .01; OR: 0.603, 95% CI: 0.415–0.699, P < .001; for IL-6 and TNF-α, respectively) was a protective factor.
In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Therefore, we should pay more attention to the pathological damage caused by these alterations.
Aggressiveness of solid pseudopapillary neoplasm of the pancreas
Authors: Hao Emmanuel II Uy , Hwang Ho Kyung , Yoon Dong-Sub , Lee Woo Jung , Kang Chang Moo 
Published: December 2018

Abstract

Background:
Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare tumors considered to be benign although 10% to 15% of SPNs have been reported to be aggressive. Due to its rarity, there have only been a few cases reported regarding the clinical course of patients with aggressive SPNs. The goal of this study is to describe the clinical course of patients diagnosed with aggressive SPNs.

Methods:
A PubMed search was done looking for articles describing the clinical course of patients diagnosed with SPN that locally invaded, recurred, or metastasized. Institutional experience was also added to the pooled data. Patient information was extracted from the articles. Survival and recurrence curves were plotted and factors associated with survival and recurrences were analyzed.

Results:
A total of 59 patients were identified to have aggressive SPN. Seven patients were males and 52 were females and the mean age was 37.44 ± 2.21 years. Systemic metastasis constituted 81.4% while recurrence and deep tissue invasion were found in 11.9% and 6.8% of the patients, respectively. Disease-free survival was 45 ± 6.28 months and disease-specific survival was 152.67 ± 12.8 months. In survival analysis, age, gender, tumor size, tumor location, combined resection, type of recurrence, and stage IV on diagnosis were not significant factors in predicting survival. However, an unresectable tumor (hazards ratio [HR] = 4.871, 95% confidence interval [CI] 1.480–16.03, P = .009), and metastasis within 36 months (HR = 6.399, 95% CI: 1.390–29.452, P = .017) were identified as independent variables in predicting survival.

Conclusion:
SPNs of the pancreas carry a favorable course. Despite having aggressive properties, patients can still survive for more than 10 years as long as the tumor can be resected completely.
CLDN10 single nucleotide polymorphism rs1325774 alters the risk of breast cancer in south chinese women
Authors: Liao Jinling , Li Jie , Cheng Hong , Chen Yang , Mo Zengnan 
Published: December 2018

Abstract
Breast cancer is one of the most widespread malignancies in females, and the incidence rate has been increasing in recent years in the world. Genetic factors play an important role in the occurrence of breast cancer. Our study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) of claudin 10 (CLDN10) (rs1325774, rs7333503, rs3751334) and breast cancer and the clinical characteristics of patients.
A total of 104 patients with breast cancer and 118 healthy controls were recruited in our study between 2013 and 2015. The SNPscan system was used for genotyping. Demographic information, health status, anthropometric parameters and clinical data were considered in analysis. Statistical analysis of the data was carried out using the Student t test, the Chi-square test (X2) or Fisher exact test and unconditional logistic regression analysis. The Gene Expression Profiling Interactive Analyses application (GEPIA) was used to analysis the expression of CLDN10 in breast cancer tissues and normal samples.
The polymorphism of rs1325774 was significantly associated with an increased risk of breast cancer (T/G vs T/T: OR = 2.073, 95% CI = 1.095–3.927, P = .025). After adjusting for age, the association remained statically significant (T/G vs T/T: OR = 2.067, 95% CI = 1.070–3.867, P = .026). Furthermore, harbouring G allele in rs1325774 position was significantly associated with increased risk of breast cancer (OR = 1.993, 95% CI = 1.107–3.589, P = .022). However, no significant association among rs7333503, rs3751334, and breast cancer. The expression level of CLDN10 was reduced in breast cancer tissues compared with normal breast tissues according to the analysis of The Cancer Genome Atlas (TCGA) data through GEPIA.
Our results suggest that the polymorphism of rs1325774 associate with increase the breast cancer risk. No significant relationship between rs1325774 polymorphism and clinical as well as pathological characteristics in patients.
Primary cutaneous anaplastic large cell lymphoma arising from a long-standing erythema nodosum
Authors: Ma Liang-Liang , Han Shi-Xin , Fang Mei-Yun 
Published: December 2018

Abstract

Rationale:
Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare subtype of non-Hodgkin lymphoma, which is rarely associated with erythema nodosum (EN).

Patient concerns:
A 57-year-old woman complained of recurrent rashes involving her abdomen, back, upper and lower limbs for over 20 years, with severity in symptoms for 2 weeks.

Diagnoses:
The first skin biopsy was performed in 2011 in another hospital and she was diagnosed idiopathic EN. The second skin biopsy was performed in 2014 and she was diagnosed as pcALCL with stage IA.

Interventions:
She was treated with oral prednisone, cyclosporine, and thalidomide.

Outcomes:
One month later, the ulcerative lesion was decreased in size and became smooth and the patient achieved partial remission. She is still under treatment and has been monitored closely for 4 years.

Lessons:
The case suggested that stimulation of inflammation in the skin lesions for a long period might be related to clonal transformation into pcALCL and hence should be closely monitored. Immunosuppressive treatment may be effective and safe for patients with pcALCL at early stages.
Accuracy and safety of percutaneous periacetabular screw insertion using screw view model of navigation in acetabular fracture
Authors: Zhao Jian-Wu , Yu Tong , Chu Guang-Yu , Zhang Xi-Wen , Wang Yao , Zhu Xiu-Jie , Jiang Qi-Yao , Jiang Zhen-De , Wang Dong-Sheng 
Published: December 2018

Abstract

Rationale:
The purpose of this study was to estimate the efficacy and safety of percutaneous periacetabular screw (PPS) insertion assisted by screw view model of navigation (SVMN) to treat fracture of acetabulum.

Patient concerns:
A 61-year-old male patient was injured in a motorcycle accident, which caused pain, swelling, deformity and limited mobility on his right hip.

Diagnoses:
He was diagnosed with fracture of acetabulum.

Interventions:
We used PPS insertion assisted by SVMN to treat fracture of acetabulum in this patient.

Outcomes:
The follow up lasted 24 months. Totally 2 screws were inserted into anterior and posterior column of acetabulum respectively and both of them displayed grade 0. Compared with the preoperative gap and step of fracture displacement, the postoperative ones were significantly reduced. It took 11.7 minutes for designing the screws, 6.7 minutes for implanting the guide wire, and 45.5 minutes for placing the screws. Intraoperative blood loss was 29 mL and total fluoroscopic time was 4.1 minutes. No clinical complications such as nerve vascular injury, infection and screw loosening were found after the operation.

Lessons:
The study indicated that SVMN is favorable to the PPS insertion for acetabular fracture. Our lesson is that the relative position between the acetabular and the patient tracker must be static to ensure the accuracy of the entire system throughout the operation.
Genetic polymorphisms of ERCC-1 and ERCC-2 are not prognostic markers in osteosarcoma patients with chemotherapy
Authors: Liu Dabiao , Liu Xuesong 
Published: December 2018

Abstract

Aim:
To make an accurate estimation of the association of ERCC1 and ERCC2 polymorphisms with osteosarcoma (OS) prognosis in Chinese population.

Methods:
Total 7 qualified studies with 1404 osteosarcoma patients were included. Odds ratios (OR) with 95% CIs were pooled for the survival rate in different osteosarcoma patients with ERCC1 and ERCC2 genetic polymorphisms. The heterogeneity was assessed by I2 test. Potential publication bias was assessed by Begg funnel plot and Egger linear regression test.

Results:
In rs11615, no significant association was found under dominant [TT+TC vs. CC: OR = 1.252, 95% CI:0.864–1.815, P = .235], recessive [TT vs. TC+CC: OR = 0.850, 95% CI: 0.695–1.030, P = .095] or allelic model [T vs. C Allele: OR = 1.219, 95% CI: 0.922–1.612, P = .165]. In rs13181, no significant association was found under dominant [AA+AC vs. CC: OR = 1.031, 95% CI: 0.800–1.329, P = .801], recessive [AA vs. AC+CC: OR = 1.005, 95% CI: 0.875, 1.154, P = .944] or allelic model [A vs. C Allele: OR = 1.009, 95% CI: 0.903–1.128, P = .870]. In rs1799793, no significant association was found under dominant [GG+GA vs. AA: OR = 1.134, 95% CI: 0.884–1.454, P = .322, recessive [GG vs. AG+AA: OR = 1.025, 95% CI: 0.881–1.192, P = .750], or allelic model [G vs. A Allele: OR = 1.046, 95% CI: 0.930–1.177, P = .450].

Conclusion:
This study did not support rs11615, rs13181 or rs1799793 to be used as surrogate markers for clinical outcome of osteosarcoma with chemotherapy.
Morphological evaluation of cervix using MRI at 32 to 36 weeks of gestation
Authors: Liu Wen , Chen Xin , Sun Cong , Wei Xinhong , Wang Guangbin , Shan Ruiqin 
Published: December 2018

Abstract
This study is to investigate the role of cervical morphology evaluated by magnetic resonance imaging (MRI) in predicting invasive placenta previa (IPP).
Totally 105 cases of pregnant women underwent prenatal placental MRI at 32 to 36 weeks of gestation for suspected IPP were included in this study. Cervical morphology (cervical length and placental protrusion) was evaluated independently by 2 radiologists. The association between the cervical morphology and surgery findings was analyzed.
Totally, 57 pregnant women were confirmed as IPP. For invasion degree, there were 17 cases with placenta percreta and 40 with accreta. For invasion topography, there were 27 cases with S1 invasion and 30 with S2 invasion. The sensitivity and specificity for the MRI sign of placental protrusion in evaluating cervical invasion of IPP were 100% and 100%, respectively. All the 7 IPP patents with cervical invasion received total hysterectomy and had severe blood loss (3500–6000 mL). The IPP patients with S2 invasion had shorter cervical length than those with S1 invasion (2.66 ± 0.66 cm vs 3.24 ± 0.64 cm, P <.001). However, cervical lengths did not correlate with the degree of invasion (placenta percreta vs placenta accreta: 2.82 ± 0.86 vs 2.99 ± 0.60, P = .21).
Placental protrusion is a reliable MRI sign for cervical invasion of IPP, and cervical lengths correlate with the invasion topography.
Secondary lymphedema after high ligation of the great saphenous vein surgery
Authors: Chen Ping , Chen Hui , Yang Mu , Wang Xuan 
Published: December 2018

Abstract
A 56-year-old male patient with secondary lymphedema in a single lower extremity presented to our hospital.
He received high ligation of great saphenous vein 3 years ago. Severe infection was observed in affected limb on postoperative day 10, and rapidly progressive pain and erythema spreading to inguinal region. He was diagnosed with secondary lymphedema after 3 years of high ligation of great saphenous vein. Compression treatment was given in affected limb to promote the lymphatic return.
The patient was followed up for 3 months now, the edema in right leg showed attenuation compared with before.
The effect of apatinib in the treatment of sorafenib resistant metastatic hepatocellular carcinoma
Authors: Han Zonghong , He Zhongming , Wang Caoye , Wang Qi 
Published: December 2018

Abstract

Rationale:
Most patients with hepatocellular carcinoma (HCC) have lost the chance of radical treatment at the time of their visit, and the prognosis of metastatic HCC is even worse. Sorafenib is currently regarded as a first-line systemic therapy in patients with advanced and metastatic HCC. Apatinib is a new inhibitor of vascular endothelial growth factor receptor 2 tyrosine kinase, which has been reported to be effective in some solid tumors. We herein report a case of apatinib in the treatment of the patient with metastatic HCC who was resistant to sorafenib.

Patient concerns:
A 41-year-old Chinese man with a history of chronic hepatitis B had undergone an emergency partial hepatectomy for tumor ruptured. Despite the treatment with transcatheter arterial chemoembolization and sorafenib, the progression of tumor failed to control.

Diagnoses:
Although the patient had been treated with sorafenib (400 mg, twice daily) for 10 months, computed tomography documented radiological progression.

Interventions:
Due to disease progression, failure of sorafenib and positive expression of vascular endothelial growth factor (VEGF), the drug regimen was changed to apatinib 250 mg once daily. Due to some degree of resistance, the dose was increased up to 425 mg once daily.

Outcomes:
The patient had a disease-free progression of 7 months at 250 mg apatinib. The dosage was adjusted to 425 mg due to drug resistance and the side effects were tolerable. The patient has survived a total of 19 months under apatinib.

Lessons:
Apatinib may be a substitute for the HCC patients with sorafenib resistance in the future, especially for those with high expression of VEGF.
Machine learning methods for automatic pain assessment using facial expression information
Authors: Liu Dianbo , Cheng Dan , Houle Timothy T. , Chen Lucy , Zhang Wei , Deng Hao 
Published: December 2018

Abstract

Introduction:
Prediction of pain using machine learning algorithms is an emerging field in both computer science and clinical medicine. Several machine algorithms were developed and validated in recent years. However, the majority of studies in this topic was published on bioinformatics or computer science journals instead of medical journals. This tendency and preference led to a gap of knowledge and acknowledgment between computer scientists who invent the algorithm and medical researchers who may use the algorithms in practice. As a consequence, some of these prediction papers did not discuss the clinical utility aspects and were causally reported without following related professional guidelines (e.g., TRIPOD statement). The aim of this protocol is to systematically summarize the current evidences about performance and utility of different machine learning methods used for automatic pain assessments based on human facial expression. In addition, this study is aimed to demonstrate and fill the knowledge gap to promote interdisciplinary collaboration.

Methods and analysis:
We will search all English language literature in the following electronic databases: PubMed, Web of Science and IEEE Xplore. A systematic review and meta-analysis summarizing the accuracy, interpretability, generalizability, and computational efficiency of machine learning methods will be conducted. Subgroup analyses by machine learning method types will be conducted.

Timeline:
The formal meta-analysis will start on Jan 15, 2019 and expected to finish by April 15, 2019.

Ethics and dissemination:
Ethical approval will be exempted or will not be required because the data collected and analyzed in this meta-analysis will not be on an individual level. The results will be disseminated in the form of an official publication in a peer-reviewed journal and/or presentation at relevant conferences.

Registration:
PROSPERO CRD42018103059.