bluuebunny/crossref_metadata_2025_split huggingface dataset:
A specific gene expression program underlies antigen archiving by lymphatic endothelial cells in mammalian lymph nodes
Authors: Tamburini Beth , Sheridan Ryan , Doan Thu , Lucas Cormac , Forward Tadg , Fleming Ira , Uecker-Martin Aspen , Morrison Thomas , Hesselberth Jay 
Published: December 2024

Abstract

Lymph node (LN) lymphatic endothelial cells (LEC) actively acquire and archive foreign antigens. Here, we address questions of how LECs achieve durable antigen archiving and whether LECs with high levels of antigen express unique transcriptional programs. We used single cell sequencing in dissociated LN tissue and spatial transcriptomics to quantify antigen levels in LEC subsets and dendritic cell populations at multiple time points after immunization and determined that ceiling and floor LECs archive antigen for the longest duration. We identify, using spatial transcriptomics, antigen positive LEC-dendritic cell interactions. Using a prime-boost strategy we find increased antigen levels within LECs after a second immunization demonstrating that LEC antigen acquisition and archiving capacity can be improved over multiple exposures. Using machine learning we defined a unique transcriptional program within archiving LECs that predicted LEC archiving capacity in mouse and human independent data sets. We validated this modeling, showing we could predict lower levels of LEC antigen archiving in chikungunya virus-infected mice and demonstrated in vivo the accuracy of our prediction. Collectively, our findings establish unique properties of LECs and a defining transcriptional program for antigen archiving that can predict antigen archiving capacity in different disease states and organisms.
Linking Changes in Sulcal Morphology to Cognitive Development from Childhood to Adolescence
Authors: Li Shuyu , Shan Yijin , Qiao Huiting , He Yirong , Chu Lei , Zeng Debin , Zhao Tengda , Liao Xuhong , Chen Xiaodan , Xia Yunman , Lei Tianyuan , Sun Lianglong , Men Weiwei , Wang Yanpei , Wang Daoyang , Hu Mingming , Pan Zhiying , Tan Shuping , Gao Jia-Hong , Qin Shaozheng , Tao Sha , Dong Qi , He Yong 
Published: December 2024

Abstract

Throughout childhood and adolescence, the development of motor skills and cognitive functions is accompanied by concurrent changes in the morphology of cortical sulci. In this study, we analyzed structural MRI (sMRI) data from a longitudinal cohort of 312 children (145 females) aged 6 to 14 years to reconstruct and label the brain's sulci, followed by mixed-effects modeling to assess age-related morphological changes. We further investigated the relationship between morphological changes and cognitive development during this period via the least absolute shrinkage and selection operator (LASSO) method. Our results revealed a significant increase in the width of secondary/tertiary sulci compared with primary sulci. An increased width of the secondary intermediate ramus of the intraparietal sulcus in children predicted improvements in Attention Network Test performance, whereas an increased width of the posterior intralingual sulcus was most strongly associated with improvements in working memory performance. Through gene enrichment analysis, we discovered that the age-related changes in sulcal morphology are linked to underlying biological processes, including synaptic reorganization and myelination. This study enhances our understanding of the relationship between sulcal morphology and cognitive function, highlighting mechanisms that may influence brain development from childhood to adolescence.
Влияния содержания бересты в пресс-сырье на свойства пластика без связующих на основе березовых опилок
Authors: Артёмов А. В. , Власов Н. Г. , Ершова А. С. , Вураско А. В. , Бурындин В. Г. 
Published: December 2024

Были получены образцы пластика без связующего (ПБС) на основе древесного наполнителя с различным соотношением бересты березы. Образцы ПБС прессовались в герметичной пресс-форме под давлением 40 МПа и температуре 180 °С с последующим ее охлаждением без снятия давления до 40 °С. У полученных образцов были исследованы показатели плотности, прочности при изгибе, модуля упругости при изгибе, твердости по Бринеллю, ударной вязкости, водопоглощения и разбухания за 24 ч, биостойкости по отношению к почво-грунту за 90 суток и активному грунту за 105 суток. Также осуществлялась оценка гидрофобности по краевому углу смачивания. На основании полученных результатов испытаний было установлено рациональное соотношение пресс-композиции на основе березовых опилок с добавлением бересты 50%. При данном соотношении достигаются следующие показатели материала: плотность – 909 кг/м3 ; модуль упругости – 1566 МПа; прочность при изгибе – 8,9 МПа; твердость по Бринеллю – 17 МПа; ударная вязкость – 3,818 кДЖ/м2 ; водопоглощение за 24 ч – 32%; разбухание – 7%. Выявлена зависимость роста биостойкости ПБС с увеличением содержания бересты в пресс-материале, что объясняется ее высокой гидрофобностью и антисептическими свойствами.
Samples of plastic without resin (PWR) were produced using a wood filler with varying proportions of birch bark. The PWR samples were pressed in a sealed mold under a pressure of 40 MPa and at a temperature of 180 °C, followed by cooling without pressure release until reaching 40 °C. The resulting samples underwent testing for density, flexural strength, flexural modulus of elasticity, Brinell hardness, impact toughness, water absorption, and swelling after 24 hours. Additionally, biostability was assessed in soil for 90 days and in active soil for 105 days. Hydrophobicity was also evaluated based on the contact angle. Based on the test results, the optimal composition ratio for the press material was determined using birch sawdust with a 50% addition of birch bark. At this ratio, the material exhibited the following properties: density – 909 kg/m³, modulus of elasticity – 1566 MPa, flexural strength – 8.9MPa, Brinell hardness – 17 MPa, impact toughness – 3.818 kJ/m², water absorption in 24 hours – 32%, and swelling – 7%. A correlation was found between increased birch bark content in the press material and enhanced biostability, attributed to its high hydrophobicity and antiseptic properties.
Субпопуляционный состав лимфоцитов костного мозга при хроническом лимфоцитарном лейкозе у пациентов с различным ответом на противоопухолевое лечение
Authors: Селютина Олеся Николаевна , Златник Е. Ю. , Гуськова Н. К. , Новикова И. А. , Лысенко И. Б. , Сагакянц А. Б. , Пушкарева Т. Ф. , Владимирова Л. Ю. 
Published: December 2024

AIM. To analyze the bone marrow lymphocyte subpopulation based on targeted assessment of PD-1, PD-L1, and LAG-3 marker expression in chronic lymphocytic leukemia (CLL) patients with different responses to chemotherapy.
MATERIALS & METHODS. In 33 CLL patients, PD-1, PD-L1, and LAG-3 antigen expression on В-, Т-, and NK-cells of the bone marrow (BM) was analyzed by flow cytofluorometry prior to treatment and after 6 cycles of chemotherapy with rituximab. Patients were aged 58–68 years (median 64 years); there were 14 women and 19 men. Hematologic response was assessed by measurements of minimal residual disease (MRD). On this basis, patients were divided into two groups: group 1 (n = 20) with satisfactory hematologic response (MRD < 1 %) and group 2 (n = 13) with unsatisfactory hematologic response (MRD ≥ 1 %).
RESULTS. Prior to treatment, the count of PD-1-, LAG-3-, CD38-, and ZAP-70-expressing BM tumor B-cells was lower in patients of group 1 than in those of group 2. After treatment, their decrease was more pronounced in group 1. Prior to treatment, patients in group 1 had a higher count of BM T-lymphocytes with CD3+, CD4+, CD8+, CD8+/CD28+, CD8+/CD28–, and CD8+/CD38+ phenotype including PD-1- but neither PD-L1- nor LAG-3-expressing T-cells.
After treatment, increased T-cells with CD3+, CD4+, CD8+, Treg, CD8+/CD28+, and CD8+/CD28– phenotype including PD-1+ T-lymphocytes were detected in both groups but more pronounced in group 2. In this group, CD3+ и CD4+ T-lymphocytes maintained LAG-3 expression. Prior to treatment, all patients showed decreased NK-cells in BM. After treatment, group 1 showed a higher count of NK-cells with CD3–/CD16+/CD56+ and CD3–/CD16+/CD56+/PD-1+ phenotype and a lower count of NK-cells with CD3–/CD16+/CD56+/LAG-3+ phenotype. PD-L1 expression in NK-cells was not detected, whereas in Т- and В-cells it was moderate prior to treatment and was not identified after hematologic response was achieved.
CONCLUSION. The values determined by the targeted assessment of PD-1 and LAG-3 expression in BM В-, Т-, and NK-cells prior to chemotherapy may well be used in clinical practice as additional prognostic factors in CLL. PD-1 and LAG-3 overexpression in Т-lymphocytes and NK-cells in CLL patients with MRD-positive status after chemotherapy can be regarded as evidence of the functional deficiency of these cells.
Las obligaciones propter rem o ambulatorias. Análisis en el derecho romano – el Código Civil – el Código civil y Comercial - el caso especial del derecho real de propiedad horizontal = The propter rem or ambulatory obligations. Analysis in roman law – the Civil Code – the Civil and Commercial code – the special case of the real law of horizontal property
Authors: Marmissolle Guarisco Ronald Alfredo , Palomanes Ana María 
Published: December 2024

En el presente trabajo se ha realizado una revisión sobre el régimen de las denominadas obligaciones propter rem o ambulatorias; desde el Derecho Romano, pasando por el régimen del Código Civil para concluir con la regulación en el Código Civil y Comercial y el caso particular de la propiedad horizontal.

Abstract: In this work, a review has been carried out on the regime of the so-called propter rem or ambulatory obligations; from Roman Law, passing through the Civil Code regime to conclude with the regulation in the Civil and Commercial Code and the particular case of horizontal property.
Pengaruh Partai Sayap Kanan dalam Pelaksanaan Kebijakan Muslim Ban: Studi Komparasi Amerika Serikat, Australia, India dan Denmark pada Tahun 2017-2021
Authors: Anindita Marsaa - , Fahadayna Adhi Cahya 
Published: December 2024

Penelitian ini mengkaji kebijakan "Muslim Ban" yang diterapkan di Amerika Serikat, Australia, India, dan Denmark dalam konteks persepsi negatif terhadap Islam pasca peristiwa 9/11. Dengan menggunakan metode komparatif dan analisis regresi linear berganda, penelitian ini meneliti faktor-faktor yang mempengaruhi kebijakan tersebut, seperti persepsi masyarakat terhadap Islam sebagai ancaman, trauma nasional, arus imigrasi internasional, dan pengaruh kebijakan AS. Hasil analisis menunjukkan bahwa di Amerika Serikat, semua variabel berpengaruh signifikan terhadap kebijakan Muslim Ban, dengan Klaim Pemimpin Mewakili Rakyat sebagai faktor paling berpengaruh. Sementara itu, di Australia, hanya Penggunaan Isu Populis yang mendekati signifikansi, dan di India serta Denmark, tidak ada variabel independen yang menunjukkan pengaruh signifikan. Temuan ini mencerminkan kompleksitas dan perbedaan dalam penerapan kebijakan di negara-negara tersebut, serta implikasinya terhadap kualitas demokrasi dan perlakuan terhadap komunitas Muslim. Penelitian ini diharapkan dapat memberikan wawasan yang lebih mendalam tentang kebijakan diskriminatif dan tantangan dalam menjaga nilai-nilai demokrasi di tengah masyarakat multikultural.
Evaluation of Prediction Performances of Deep Learning Models for the Aerodynamic Characteristics of Flettner Rotors
Authors: Seo Janghoon , Park Jung Yoon , Ma Juhwan , Kim Young Bu , Park Dong-Woo 
Published: December 2024

Abstract
This study investigates the prediction of the aerodynamic characteristics of Flettner rotors through three deep learning models. Various numbers of Flettner rotors, arrangements, and spin ratios are employed to consider these effects in the dataset. For the training of deep learning models, a dataset of aerodynamic force coefficients and flow fields is generated using Computational Fluid Dynamics (CFD). Three deep learning architectures (U-net, Encoder-Decoder, and Decoder models) are employed and trained to predict the aerodynamic characteristics of Flettner rotors. Three deep learning models are established through a training stage with a hyperparameter study and by altering the number of layers. The aerodynamic force coefficients and flow fields are predicted by established deep learning models and show small absolute errors compared to those from the CFD analysis. Moreover, predicted flow fields reflect the flow characteristics according to the difference of spin ratio and arrangement of Flettner rotors. In conclusion, the established deep learning models demonstrate rapid and robust predictions of aerodynamic force coefficients and flow fields for Flettner rotors under varying arrangements and spin ratios. Furthermore, a significant reduction in computational time is measured when comparing the analysis time of CFD simulations to the training and testing time of the deep learning models.
A Digital Twin Comprehensive Monitoring System for Ship Equipment
Authors: Miao Zhe , Zhao Yong , Su Shaojuan , Song Nanzhe 
Published: December 2024

Abstract
In this study, a comprehensive digital twin monitoring system for ship equipment was designed and implemented, including the system architecture, key technologies, and applications. Through data-driven models and operational monitoring system analysis, our PSO-SVM-based time series prediction method demonstrated excellent predictive capabilities for catamaran equipment, achieving efficient fault warnings using a threshold method. The digital twin model and virtual scenarios constructed here provide a visualisation and simulation platform for equipment status monitoring, enhanced fault diagnosis and support for maintenance decisions. The system integrates real-time monitoring, fault warning, and data analysis, and testing results show good stability and accuracy. In addition, the system optimises the user experience through multi-round feedback testing, and ensures data security and privacy protection through multi-layer encryption, identity verification, and role-based access control. A case study indicates that the proposed system effectively monitors equipment status and provides fault warnings, and has broad application prospects and practical value. Future work will focus on optimising the functionality and improving the applicability and security of the system.
Investigating the Coupling Effects of Momentum Wake-Buoyancy Jets in Thermohaline Stratification: A Simulation Study
Authors: Yongcheng Du , Changgeng Shuai , Feiyang Luo , Chengzhe Gao 
Published: December 2024

Abstract
This study analyses the impact of varying temperature and salinity stratifications on the thermal characteristics of the wake through a newly established simulation model, the reliability of which is confirmed by experimental validation. In a stratified environment with sTable positive salinity but a temperature changing from positive to negative, the wake has “cold” and “hot” characteristics at the free liquid surface, respectively, and these characteristics are enhanced with an increase in the temperature gradient. In a stratified environment with a sTable positive temperature but changing positive salinity, the wake stream has “cold” characteristics at the free liquid surface, and the feature intensity has a weak positive correlation with the salinity gradient. In general, under the boundary and initial conditions studied in this paper, temperature stratification is the main factor determining the thermal characteristics of the free surface, and salinity stratification is the secondary factor. The influence of the moving induced wake on the thermal characteristics of the wake is stronger than that of the buoyant jet. In a follow-up study, we will focus on a scale analysis of the impact of stratified features on the wake, and scale extrapolation. The influence of the free surface thermal boundary layer on the wake characteristics will be another key point for investigation.
50 Years of scientific thought on Machine Diagnostics in PolanD anD its influence on MaritiMe aPPlications
Authors: Klekot Grzegorz , Dąbrowski Zbigniew , Dziurdź Jacek 
Published: December 2024

Abstract
This article presents a condensed outline of how approaches to solving technical diagnostics tasks have changed over the last 50 years. It reviews different approaches to the modelling of wear and tear phenomena that are the subject of diagnosis, and draws attention to groundbreaking papers which are still of topical interest. Particular emphasis is placed on the development of vibroacoustic diagnostics methods, an area in which Polish scientists were among the world’s avant garde. It is also shown how methodologies have changed with the progress of digital signal analysis. The example presented in the second part of the article demonstrates that the well-known and technically important task of diagnosing a gear set can now be solved without looking for a classic state→symptom relationship through an accurate dynamic description of the machine and comparing it with the results of an experiment, but instead by comparing observations at different points in the n-dimensional space with an abstract pattern generated by a sequence of logical transformations. This formulation of the task opens up avenues for AI methods. Attention is paid to the fact that maritime shipping is one of the main fields of application for modern diagnostic methods, and it is shown that the increase in the accuracy of vibroacoustic diagnostics techniques and the correctness of the diagnosis allows for the use of this methodology in marine applications.
Influence of Lubrication Water Contamination by Solid Particles of Mineral Origin on Marine Strut Propeller Shafts Bearings of Ships
Authors: Litwin Wojciech , Barszczewska Agnieszka , Piątkowska Ewa , Szwoch Izabela , Matuszewski Leszek , Kahsin Maciej 
Published: December 2024

Abstract
The stern tube or strat bearings are key important component for safety of shipping. Modern global regulations required a low as possible negative impact on environment including lubricants leaking to the sea. The ship owners are looking for reliable and durable solutions. The costs of each ship components are carefully studied. The water lubricated bearings for ship propeller shafts are an environmentally friendly solution. That is the reason why water lubrication is an interesting option to consider. Because simplicity of the ship design is expected the open lubricating system with only one seal module, when sea water is a lubricant is often recommended by manufacturer.
This research was inspired by a series of failures or premature excessive wear of the propeller shaft strut bearings of real ships. The experimental tests were conducted in the laboratory on custom designed and build test-rig. The large group of tested bearings was delivered by certified manufacturers.
The results of long time wear tests clearly prove that the cause of this premature wear was abrasive wear resulting from water contamination with solid particles of mineral origin. The range of the wear strongly depends on bearing bush materials and bearing interspace geometry. The wear was low for bearings with elastic bushes especially when hydrodynamic phenomena takes place.
The general conclusion is that water lubrication is an interesting option to consider when design of the ship is discussed. The simplicity resulting an attractive price, low maintenance costs and proven durability and reliability of some bearings materials cause that this technology is becoming popular and often applied.
Effect of Vitamin D Supplementation on Serum Lipid Profile in Patients With Cardiovascular Risk
Authors: Frențușcă Claudia Florina , Babeș Katalin 
Published: December 2024

Abstract

Introduction
Existing evidence suggests vitamin D may benefit serum lipid profiles and, thus, cardiovascular health. The present study aimed to evaluate the effect of oral daily vitamin D supplementation on lipid profile among patients with cardiovascular risk.

Material and Methods
A total of 154 patients were included in the study, aged over 18 years, with at least one cardiovascular risk factor. Blood samples were collected at baseline and a 6-month follow-up. About 100 patients received vitamin D supplements in addition to the statin treatment, and 54 benefited from oral vitamin D treatment only.

Results
The serum level of vitamin D showed a significant increase after 6 months of treatment: from a mean basal level of 18.5 ng/ml (± 9.0) to a mean level at 6 months of 43.1 ng/ml (± 9.5) – p<0,0001. In the group treated only with vitamin D supplements, a significant improvement was observed in the total cholesterol and LDL cholesterol levels, even if the patients did not benefit from statin treatment. Among patients who also received statins, differences were observed in changes in serum LDL cholesterol, HDL cholesterol, and triglycerides, in that the decreases observed were more pronounced than those who received only vitamin supplementation D.

Conclusion
Vitamin D supplementation appeared to have a beneficial effect on lipid profile. Vitamin D supplementation may be useful in dyslipidemia patients at high risk of cardiovascular diseases.
The Amazon in the Context of the Climate Crisis: the Contradiction Between the Environmental Emergency and the Economic Interests
Authors: Oliveira Manoela Hoffmann , Oliveira Anna Hoffmann 
Published: December 2024

Objective: This article, through a critically sociological and interdisciplinarily grounded analysis of the environmental crisis, presents the intricate mechanisms within the economic, political, and legal domains that Lula’s government must confront in the context of Amazonian destruction.

Theoretical Framework: Despite the social and scientific recognition, the historical dimension of the gravity of the climatic situation, and the disastrous consequences of Amazon deforestation, the socioeconomic mechanisms that hinder the resolution of this collapsing scenario have not yet been adequately addressed nor entirely comprehended.
Method: The study considered up-to-date qualitative and quantitative data obtained from bibliographical and documentary research in reputable national and international sources.

Results and Discussion: The deforestation rate within the biome is declining; however, the state environmental policy maintains its rate in its energy plan with new oil wells, regularization of illegally acquired lands, and projects such as a railway crossing the forest, all questioned by the Minister of the Environment, Marina Silva. A pivotal aspect regarding Brazil, which prevailed during Lula’s term and several governments, is land concentration.

Research Implications: Although the current government, in contrast to its predecessor, has promised to engage in a conservationist revival of the forest, primarily focusing on eradicating deforestation and enforcing and rebuilding climate diplomacy, it is crucial to acknowledge the significant limitations of this attempt.

Originality/Value: The destruction of the Amazon presents itself as a necessity and constitutes a method that better serves an economic objective than socio-environmental sustainability. Clarity regarding these matters must fundamentally underlie the anticipation of realistic scenarios, all studies, and policies for mitigating and adapting to climate change.