bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atomic Interaction S. aureus/Machined and Additive Manufacturing Ti‐6Al‐4V and Ti‐35Nb‐7Zr‐5Ta Disks for Dental Implants
Authors: Tardelli Juliana Dias Corpa , Otani Lucas Barcelos , Batalha Rodolfo Lisboa , Alves Fernanda , Pereira‐da‐Siva Marcelo A. , Bagnato Vanderlei Salvador , Gargarella Piter , Bolfarini Claudemiro , dos Reis Andréa Cândido 
Published: November 2024

ABSTRACTThe adhesion strength of a bacterial strain on a substrate influences colonization and biofilm development, so the biomolecular analysis of this interaction is a step that allows insights into the development of antifouling surfaces. As peri‐implantitis is the main cause of failure of implant‐supported oral rehabilitations and the dental literature presents gaps in the atomic bacteria/surface interaction, this study aimed to correlate the qualitative variation of roughness, wettability, chemical composition, and electrical potential of Ti‐6Al‐4V and Ti‐35Nb‐7Zr‐5Ta (TNZT) disks obtained by machining (M) and additive manufacturing (AM) on the colonization and adhesion strength of S. aureus quantified by atomic force microscopy (AFM). The samples were evaluated for roughness, electrical potential, and S. aureus colonization and adhesion strength by specific methods in the AFM with subsequent analysis in the NanoScope software analysis, wettability by sessile drop method, and chemical composition by energy dispersive x‐ray spectroscopy (EDX). Qualitative data were correlated with bacterial adhesion strength. The greater adhesion strength of S. aureus was observed in descending order for TNZT AM, TNZT M, Ti‐6Al‐4V AM, and Ti‐6Al‐4V M. This experimental in vitro study allowed us to conclude that for the evaluated groups, the strength adhesion of S. aureus showed a linear relationship with roughness, and nonlinear for wettability, electrical potential, and S. aureus colonization on the surfaces evaluated. As for the two variation factors, type of alloy and manufacturing method, those that promoted the lowest bacterial adhesion strength were Ti‐6Al‐4V and M, possibly attributed to the synergistic modification of the evaluated surface properties. Thus, this study suggests S. aureus preferences for rough, hydrophilic surfaces with a greater electrical potential difference.
Optimizing Electroconductive PPy‐PCL Scaffolds for Enhanced Tissue Engineering Performance
Authors: Muñoz‐González Ana M. , Clavijo‐Grimaldo Dianney , Leal‐Marin Sara , Glasmacher Birgit 
Published: November 2024

ABSTRACTThe integration of electrically conductive materials is a promising approach in tissue regeneration research. The study presented focuses on the creation of electroconductive scaffolds made from polypyrrole‐polycaprolactone (PPy‐PCL) using optimal processing parameters. Utilizing Box–Behnken response surface methodology for in situ chemical polymerization of PPy, the scaffolds exhibited a maximum conductivity of 2.542 mS/cm. Morphological examination via scanning electron microscopy (SEM) indicated uniform dispersion of PPy particles within PCL fibers. Fourier transform infrared spectroscopy (FTIR) and energy dispersive x‐ray (EDX) analysis validated the composition of the scaffolds, while mechanical testing revealed that the optimized scaffolds exhibit superior tensile strength and Young's modulus compared to scaffolds comprised only of PCL. The hydrophilicity of the scaffolds was improved considerably, transitioning from initially hydrophobic to fully hydrophilic for the optimum scaffold, making it suitable for tissue engineering applications. Cell viability assays, including MTT with L929 fibroblasts and Alamar Blue with bone marrow mesenchymal stem cells (bmMSCs), reflected no cytotoxicity. They showed an increase in metabolic activity, suggesting the capability of the scaffolds to support cellular functions. In conclusion, the in situ synthesis of PPy in the PCL matrix by optimizing the fabrication parameters resulted in conductive scaffolds with promising structural and functional properties for tissue engineering.
Alternative Anticoagulant Strategy to Improve the Test Sensitivity of ASTM F2888‐19 Standard for Platelet and Leukocyte Count Assay
Authors: Patel Mehulkumar , Serna Carlos , Parrish Anna , Gupta Arjun , Jamiolkowski Megan , Lu Qijin 
Published: November 2024

ABSTRACTThe ASTM F2888‐19 standard for platelet and leukocyte count assay is the only standardized test method for assessing platelet and leukocyte interactions with blood‐contacting device materials. This study aimed to address two limitations of the ASTM F2888‐19 standard: low test sensitivity for leukocyte count and high test sample surface area to blood ratio (12 cm2/mL). Human blood from healthy adult donors was drawn into polypropylene tubes with either 3.2% sodium (Na) citrate or anticoagulant citrate dextrose solution A (ACDA). Immediately before starting the test, the blood was recalcified and heparinized to a concentration of 1, 1.5, or 2 U/mL and incubated with the test materials of varying thrombogenic potential at an exposure ratio of 6 or 12 cm2/mL for 1 h at 37°C ± 2°C in a shaking water bath. Complete blood count was measured using a hematology analyzer. The results show that both, Na‐citrated blood (6 or 12 cm2/mL exposure ratio) and ACDA blood (6 cm2/mL ratio), were able to differentiate thrombogenic materials from commonly used biomaterials based on platelet count changes. The magnitudes of difference between the thrombogenic materials and biomaterials depends on heparin concentration. The test sensitivity was highest when ACDA blood, heparinized to 1 U/mL heparin, was used. Moreover, the use of ACDA blood, unlike Na‐citrated blood, also allowed the assay to distinguish between the thrombogenic materials from commonly used biomaterials based on leukocyte count changes. In conclusion, the use of ACDA blood significantly increased test sensitivity of the ASTM F2888‐19 test method in differentiating materials with varying thrombogenicity based on both platelet and leukocyte counts, while reducing blood exposure ratio to 6 cm2/mL. These findings will be used to revise the ASTM F2888 standard in the future.
Relative Bioavailability of Dordaviprone (ONC201) is Not Affected by Co‐Administration of the Proton‐Pump Inhibitor Rabeprazole
Authors: Faison Shamia L. , Batonga Joelle , Arumugham Thangam , Bartkus Angela , Morrison Marion , Mullin Mark J. , Tippin Tim , Naderer Odin 
Published: November 2024

AbstractDordaviprone (ONC201) is a novel, orally administered, anti‐cancer, small molecule imipridone with demonstrated antitumor effects in patients with glioma. Dordaviprone in vitro solubility is significantly reduced at pH >4.5. Concomitant use of acid reducing agents (ARAs) may therefore impact dordaviprone solubility and bioavailability. This open‐label, single‐sequence, three‐period crossover study evaluated the effect of proton‐pump inhibitor rabeprazole on dordaviprone pharmacokinetics (PK). Periods were consecutive and comprised of period 1 (days 1–3), period 2 (days 4–9), and period 3 (days 10–13). In period 1, participants received a single oral 625 mg dose of dordaviprone on day 1. In period 2, participants received six consecutive days of QD 20 mg rabeprazole alone. In period 3, patients received one oral dose of 20 mg rabeprazole (the seventh consecutive daily dose), followed 2 h later by a single 625 mg dordaviprone oral dose. PK blood samples were collected and analyzed from pre‐dose 72 h following dordaviprone administration in periods 1 and 3. Dordaviprone exposure PK parameters were similar following administration of dordaviprone alone or with rabeprazole. Geometric mean ratios and 90% CIs for dordaviprone exposure parameters with and without rabeprazole following dordaviprone administration fell within bioequivalence limits of 80.00%–125.00% for Cmax (97.19% [86.43–109.28]), AUClast (102.21% [95.19–109.75]), and AUCinf (102.27% [95.21–109.86]), indicating no effect of multiple oral doses of rabeprazole on dordaviprone relative bioavailability. Six of the 16 participants reported treatment‐emergent adverse events (TEAEs); dordaviprone‐related TEAEs were reported by three participants and were limited to mild nausea and dizziness. No dordaviprone dose adjustment or ARA treatment modification is warranted.
Body Composition and Incident High‐Intensity Back Pain and/or High Disability: A 10‐Year Prospective Population‐Based Male Cohort
Authors: Estee Mahnuma Mahfuz , Wang Yuanyuan , Heritier Stephane , Urquhart Donna M. , Cicuttini Flavia M. , Kotowicz Mark A. , Brennan‐Olsen Sharon L. , Pasco Julie A. , Wluka Anita E. 
Published: November 2024

ABSTRACTBackgroundBack pain poses a significant global burden, within which individuals with more severe symptoms consume higher healthcare expenses than those with lesser back pain. Whether measures of body composition predict high‐intensity back pain and/or high‐disability in population‐based cohorts is unknown. This study aimed to examine the association between body composition at baseline and their change in the prior 5 years (between 2001–2005 and 2006–2010) and incident high‐intensity back pain and/or high‐disability in long‐term follow‐up, 10 years later (2016–2021) in a population‐based cohort of men.MethodThis study examined men with no or low‐intensity back pain and disability (Graded Chronic Pain Scale) at back pain study baseline (2006–2010) within the Geelong Osteoporosis Study. Those developing high‐intensity pain and/or high disability at follow‐up (2016–2021) were identified. Weight, body mass index (BMI), abdominal circumferences, fat mass and lean mass (dual energy X‐ray absorptiometry) were assessed prebaseline (2001–2005) and at baseline. The association of body composition at baseline and change in body composition from prebaseline to baseline with incident high‐intensity pain and/or high disability at follow‐up were examined using multivariable logistic regression.ResultOf 695 participants with no or low‐intensity pain and disability at baseline, 441 (62.3%) completed follow‐up with a mean age of 54.3 ± 14.1 years: 37 (8.3%) developed high‐intensity pain and/or high‐disability, 33 (7.5%) developed high‐intensity pain and 14 (3.2%) high disability. No measures of body composition at baseline were associated with incident high‐intensity pain and/or high disability at follow‐up in the whole population. In subgroup analysis, among men aged over 60 years, but not younger, higher lean mass was associated with decreased likelihood of high‐intensity pain and/or high‐disability (odds ratio [OR] 0.86, 95% confidence interval [CI] 0.76, 0.97, interaction p < 0.001). In the whole population, examination of the relationship between change in measures of body composition between prebaseline and baseline, only a one unit increase in BMI, equivalent to 3.1‐kg weight gain, was associated with increased incident high disability (OR 1.63, 95% CI 1.06, 2.51).ConclusionIn a population‐based sample, without severe back pain and disability, in older men aged ≥60 years, higher lean mass was protective of incident high‐intensity pain and/or high disability. An increase in BMI, over 5 years, equivalent to 3.1‐kg weight gain, was associated with incident back pain related high disability 10 years later. These results demonstrate another detrimental consequence of weight gain and highlight the importance of maintaining muscle mass in older men.
Prenatal Ultrasound Markers of Adverse Perinatal Outcomes in Newborns With Simple and Complex Gastroschisis
Authors: Caldas João Victor Jacomele , Peixoto Alberto Borges , Rolo Liliam Cristine , Araujo Júnior Edward 
Published: November 2024

ABSTRACTObjectiveThe aim of this study was to compare prenatal ultrasound markers and perinatal outcomes in newborns with simple and complex gastroschisis.MethodsA retrospective cohort study was performed on pregnant women with gastroschisis fetuses and their respective newborns between 2009 and 2019. Binary logistic regression was used to determine the best prenatal ultrasound markers of complex gastroschisis and adverse perinatal outcomes.ResultsAfter delivery, 36 gastroschisis were classified as simple and 10 as complex. Newborns with complex gastroschisis had a higher prevalence of early neonatal death compared to newborns with simple gastroschisis (30.0% vs. 2.8%, p = 0.007). The abdominal wall defect diameter became a significant prenatal ultrasound marker of neonatal sepsis [X2: 6.31 (1), OR:0.92, CI 95% (0.85–0.98), p = 0.020]. The presence of complex gastroschisis [X2: 7.33 (1), OR: 23.25, CI 95% 1.92–280.77, p = 0.013] was the only significant predictor of early neonatal death, and the presence of complex gastroschisis increased the risk of early neonatal death by 23.25 times. There was no significant effect of the type of gastroschisis in relation to gestational age, amniotic fluid index, intra‐abdominal intestinal dilation, extra‐abdominal intestinal dilation, and thickness of the intestine diameter.ConclusionAbdominal wall defect diameter was a significant prenatal ultrasound marker of adverse perinatal outcomes in newborns with simple and complex gastroschisis. Complex gastroschisis was a significant predictor of early neonatal death.
Regulation of Insect Hormones in Different Types of Diapause in Chilo Partellus (Swinhoe)
Authors: Tanwar Aditya K. , Dhillon Mukesh K. , Trivedi Neha , Hasan Fazil , Kirti Jagbir S. 
Published: November 2024

ABSTRACTMaize stem borer, Chilo partellus (Swinhoe) is a key pest of maize and sorghum. It undergoes both in estivation and hibernation depending on prevailing environmental conditions. Present investigations were aimed to decipher the regulation of ecdysone, 20‐hydroxyecdysone (20E) and juvenile hormone III (JH III) during different stages (prediapause, diapause and post‐diapause/pupae) of hibernation and estivation as compared to counterpart nondiapause C. partellus. Significant variations were found in the ecdysone, 20E and JH III titers in the hemolymph of different stages of hibernation and estivation over the nondiapause C. partellus. At the prediapause stages of hibernation and estivation, the 20E was greater than the ecdysone. However, the ecdysone and 20E downregulated, while JH III upregulated during prediapause stages of hibernation and estivation as compared to nondiapause larvae. During diapause, 20E decreased in hibernation, and increased in estivation as compared to their respective prediapause stages. The JH III significantly upregulated in diapause stages of hibernation and estivation over the nondiapause larvae. However, it was significantly greater in prediapause and diapause stages of estivation as compared to hibernation strain. During post‐diapause stage, the ecdysone and 20E titers were greater in estivation than in the hibernation and nondiapause strains, while JH III was greater in nondiapause than in the hibernation and estivation strains. These findings suggest the crucial role of these hormones in establishing switch between different stages of diapause and metamorphosis in C. partellus, which could further be useful to strategize sustainable management of C. partellus.
Paroxysmal atrial fibrillation is associated with poor sleep quality: Tamagawa cross‐sectional study on the relationship between lifestyle and atrial fibrillation (TAMAGAWA‐AF study)
Authors: Otsuka Toshiaki , Ikegami Haruhiko , Kodani Eitaro , Sakabe Kouichi , Hatano Hirokazu , Takami Mitsuaki , Hironaka Manabu , Fukai Kenichi , Yoshimoto Kazuya ,   the TAMAGAWA‐AF Study
Published: November 2024

AbstractBackgroundQuality of life (QOL) is reduced in patients with atrial fibrillation (AF). However, data regarding the association between sleep quality, one of the major components of QOL, and AF are insufficient. This cross‐sectional study aimed to elucidate whether sleep quality is reduced in patients with AF.MethodsWe recruited 2054 consecutive outpatients (64 ± 10 years, 1089 men) who had regularly presented to 26 clinics affiliated with the Tamagawa Medical Association, Tokyo, Japan. The patients were divided into paroxysmal AF (PaAF), persistent or permanent AF (PeAF), and non‐AF groups. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). The global PSQI score was calculated according to the answer to each question, and poor sleep quality was defined as a global PSQI score ≥6 points. Logistic regression analysis was used to obtain odds ratio for poor sleep quality in the PaAF and PeAF groups, relative to the non‐AF group.ResultsThe PaAF group showed significantly increased odds ratio for poor sleep quality (1.49, 95% confidence interval 1.02–2.17), after adjusting for multiple potential confounders. In contrast, no significant odds ratio for poor sleep quality was observed in the PeAF group (1.09, 95% confidence interval 0.70–1.71). Among the PSQI components, poor subjective sleep quality and sleep disturbances were the main determinants of poor sleep quality in the PaAF group.ConclusionSleep quality was found to be reduced in patients with PaAF, and this may be attributed to poor subjective sleep quality and sleep disturbances.
Projected Changes in Diurnal Temperature Range Over India Using a Coupled Ocean–Atmosphere Regional Climate Model
Authors: Jayasankar C. B. , Misra Vasubandhu 
Published: November 2024

ABSTRACTThis study investigates the projected changes in the diurnal temperature range (DTR) over India and explains its considerable spatial heterogeneity from a 20‐km resolution coupled regional climate model (RSM‐ROMS) integration. The RSM‐ROMS is driven at the lateral boundaries by the Community Climate System Model version 4 (CCSM4) model. Observations reveal spatial heterogeneity in DTR trends with significant declining trends at many grid points interspersed with areas of either increasing or insignificant trends of DTR during each of the four seasons. The present‐day simulations from RSM‐ROMS show reasonable skill in simulating the daily maximum temperature (Tmax) and minimum temperature (Tmin) over India. Our results show a significant decrease in DTR over the Gangetic Plains in boreal winter and fall seasons and over southeastern India during boreal summer in the projected mid‐21st century climate under the RCP 8.5 emission scenario. The future reduction in DTR over Region‐1 (over Bihar and the eastern regions of Uttar Pradesh) during December–February (−0.86°C) and over Region‐3 (over the rain shadow regions of Peninsular India) during June–September (−0.49°C) is attributed to large changes in surface radiative fluxes, with some of the decrease in downward short wave flux attributed to an increase in high cloud cover at the time of Tmax while there is a considerable increase in downward longwave flux in the mid‐21st century climate. The enthalpy fluxes at the time of Tmax also act to reduce the rate of its warming. As a result, the warming rate of Tmax is less compared with the corresponding warming rate of Tmin, which leads to a reduction of the DTR in some regions that display a significant reduction in future climate. In contrast, Region‐2 (over Rajasthan) and Region‐4 (over northeast India) exhibit insignificant DTR changes in the mid‐21st century climate for lack of asymmetrical changes in Tmin and Tmax.
Otolaryngologists Demonstrate Low Agreement on Pediatric Airway Inflammation Assessment
Authors: Raj Sweeya V. , Prosak Olivia L. , O'Brien Kaitlin July , Park Jason S. , Zhao Shilin , Wootten Christopher T. 
Published: November 2024

ObjectivesMicrolaryngoscopy and bronchoscopy (MLB) are essential tools for evaluating airway inflammation, but the reliability of endoscopic assessments for this purpose remains unclear. The aim of this study was to assess surgeons' interrater reliability during endoscopic assessment of airway inflammation. The endoscopic factors used to determine overall airway inflammation were also assessed.MethodsWe conducted a cross‐sectional study involving 24 pediatric patients who underwent MLB and arytenoid biopsy. Surgeons rated airway inflammation based on endoscopic images, and interrater reliability was assessed using Fleiss' Kappa.ResultsFleiss's Kappa demonstrated poor interrater reliability among all surgeons (0.111) and experienced surgeons (0.117). Surgeons varied in prioritizing visual features for assessing inflammation.ConclusionCurrent subjective assessments of airway inflammation during MLB exhibit poor interrater reliability, necessitating further research for improved diagnostic accuracy and informed treatment decisions in pediatric airway interventions.Level of EvidenceLevel 3 Laryngoscope, 2024
Three sustainability case studies in the scholarly publishing ecosystem
Authors: Gadsby Oliver , Barsley Zoe Cokeliss , Hodgson Catherine , Davidson Scott 
Published: November 2024

Key points
Of the UN's 17 Sustainable Development Goals, academic publishers and Higher Education institutions are focusing on Environmental Sustainability.
Oxford University Press has made progress on carbon neutrality for its operations; protecting biodiversity; and minimizing waste. Its ambitions go further.
Taylor & Francis has a goal of being a net zero carbon business by 2030, and has made progress in areas including reduction of book inventory and transport.
The University of Edinburgh has set targets of achieving net zero by 2040 and zero waste by 2030. It is ambitious in its further action, aiming to lead by example.
All contributors emphasize the collaborative effort required: within their organization, across their sector, and with relevant industry bodies. They usefully explore their own roles as agents of change.
Thin‐Film‐Lithium‐Niobate Photonic Chip for Ultra‐Wideband and High‐Precision Microwave Frequency Measurement
Authors: Yan Hao , Wang Zexu , Wang Siyuan , Li Zekun , Xie Yiwei , Hong Shihan , Liu Liu , Wang Ke , Yu Zejie , Dai Daoxin 
Published: November 2024

AbstractIntegrated photonic‐assisted instantaneous frequency measurements (IFMs) have been extensively explored and widely used in 5G/6G communications, navigation, automotive control, and radar systems. They offer significant advantages such as wide frequency, low power consumption, and immunity to electromagnetic interference compared to electrical solutions. As data traffic in high‐speed wireless communication systems and the operation bandwidth of advanced radar systems continue to grow, there is an urgent need for large instantaneous bandwidths and accurate frequency measurements to ensure signal integrity and efficient bandwidth utilization. However, achieving wide‐bandwidth and high‐precision measurements simultaneously with photonic IFMs remains challenging. Here, an integrated photonic IFM system based on a thin‐film lithium niobate (TFLN) platform is demonstrated that can dynamically identify signals with wide‐band frequency changes. The system incorporates a wide‐bandwidth Mach–Zehnder modulator (MZM) and a high‐Q Mach–Zehnder interferometer (MZI)‐coupled microring resonator (MRR) for double‐sideband suppressed‐carrier (DSB‐SC) modulation. Additionally, it includes dual‐stage frequency discriminator based on asymmetric MZIs (AMZIs) for both coarse wide‐band and accurate narrow‐band measurements. The proposed IFM system operates over a wide‐band frequency up to 67 GHz with a low root mean square (RMS) error of less than 123 MHz. This work opens up a path for high‐performance broadband microwave photonic applications using TFLN platform.