bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Review of Anticancer Potential of Conferone, Diversin and Ferutinin; Which One is Stronger for Cancer Therapy?
Authors: Keshmirshekan Fariborz , Mohamadi-Zarch Seyed-Mahdi , Bagheri Seyyed Majid 
Published: November 2024

Background:
One of the growing diseases in today's human societies is cancer, which has become a
major challenge, especially in industrialized and developing countries. Cancer treatments are diverse, but they
usually use surgery, chemotherapy, and radiotherapy to improve patients. Existing drugs are usually expensive
and, in some cases, are not effective due to drug resistance and side effects. Finding compounds of natural origin
can be somewhat effective and useful in helping doctors to treat this disease. Ferula plants, which are traditionally
used as spices or for medicinal purposes, can be a good source for finding anti-cancer compounds due to their
various compounds, such as monoterpenes, sulfide compounds, and polyphenols. Several studies have shown that
compounds found in Ferula plants have significant anticancer effects on various types of cancer cells.

Objective:
This article was compiled with the aim of collecting evidence and articles related to the anti-cancer
effects of three compounds obtained from these plants, namely Conferone, Diversin, and Ferutinin.

Methods:
This review article was prepared by searching the terms Conferone, Diversin, Ferutinin and cancer and
related information was collected through searching electronic databases such as ISI Web of Knowledge, PubMed
and Google Scholar until the March of 2024.

Conclusion:
The results of this review showed that relatively comprehensive studies have been conducted in this
field and these studies have shown that these compounds can be used in the design of future anticancer drugs.
Among the examined compounds, conferone showed that it has the best effect on cancer cells.
Development, Optimization, and Evaluation of Solid Lipid Nanoparticles of Celecoxib
Authors: Verma Madhu , Nanda Arun , Gautam Manish , Chauhan Iti , Yasir Mohd. , Singh Alok Pratap , Majhi Sagarika , Kumari Raj , Sharma Meenakshi 
Published: November 2024

Background:
In the present investigation, nano-lipid technology was exploited to control
the release of celecoxib (CXB) and overcome its dissolution problem. Solid lipid nanoparticles
(SLNs) have a small particle size (50-1000 nm) that results in a large surface area-to-volume ratio,
which further enhances the contact between the drug and the dissolution medium. This leads to improved
drug release and absorption.

Aim and Objective:
This study aimed to enhance the solubility and hence improve the therapeutic
efficacy of a BCS Class-II drug-celecoxib formulating it as solid lipid nanoparticles.

Methods:
CXB-loaded-SLNs were prepared using the solvent emulsification-diffusion technique and
optimized by CCD. Characterization included FTIR, drug loading, particle size, PDI, zeta potential,
and in-vitro release and anti-inflammatory studies.

Results:
Optimized Formulation (OF1) exhibited particle size, PDI, and zeta potential were found to
be 314 nm, 0.204, and -18.73 mV, respectively, with entrapment efficiency (79±0.18 %) and drug
loading (44.38±0.21 %). The best-fitted model was the Korsemeyer-Peppas model, with drug release
of 89.42 ±0.12 % in 24 h. OF1 formulation reduced the rat paw volume to a minimum (1±0.32) in 24
h when compared to pure API (2±0.62) and marketed preparation (2±0.42).

Conclusion:
OF1 demonstrated sustained drug release with enhanced solubility and better in-vivo
anti-inflammatory studies compared to pure API.
Diosgenin Unveiled: From Nutritional Insights to Nano Applications and Molecular Marvels
Authors: Thakur Manisha , Vasudeva Neeru , Sharma Sunil 
Published: November 2024

Introduction:
Diosgenin (DSG) is a steroidal sapogenin found in plants such as Dioscorea tokoro Makino ex Miyabe, Trigonella foenum-graceum, and Solanum virgini-anum, and is utilized as a natural source of steroidal hormones. It exhibits anti-inflammatory, anti-apoptotic, anti-oxidant, and various other pharmacological properties, making it a relia-ble candidate for research purposes. The aim of this review is to provide researchers with a scientific basis for the target-specific bio-potential of DSG as an ethnomedicine and to under-score its potential for drug design and therapy modifications in the future.

Methods:
Relevant literature search up to the current year by using online databases such as Scopus, Google Scholar, PubMed, Research Gate, and Science Direct by applying related search terms.

Results:
This review first addressed the green nanotechnology that is widely adopted to improve DSG’s pharmacokinetic profile, and then listed numerous nano-formulations of DSG for enhancement of their physical properties. At last, this article ex-plored the molecular action of DSG on NF-ĸB, TGF-β1/Smad, AMPK/ACC/CPT-1A & SERBP-1c/FAS, etc. that are pathologically involved in a variety of diseases for better under-standing such as limited clinical research has been conducted to date.

Conclusion:
Overall, the current review tries to update all information about DSG's nutri-tional benefits, its application as nanomedicine, and diverse pharmacological actions based on various molecular targets for its commendable pre-clinical and clinical applications
Examining the Spillover Economic Impacts of Caregiving Among Families of Children With Medical Complexity to Inform Inclusive Economic Models: Qualitative Study
Authors: Keim-Malpass Jessica , Muir K Jane , Letzkus Lisa C , Scheer Eleanore , Valdez Rupa S 
Published: November 2024

Background
Children with medical complexity represent a heterogeneous group of children with multiple chronic health care conditions. Caregivers of children with medical complexity experience a high intensity of caregiving that is often variable, extends across several networks of care, and often lasts for the entirety of the child’s life. The spillover, or indirect, economic impacts of caregiving are understudied in the context the family units of children with medical complexity. There have been recognized limitations to the sole use of quantitative methods when developing economic models of disease, because they lack direct caregiver voice and context of caregiving activities, and existing methods have been noted to be ableist.

Objective
This study aimed to explore the economic spillover impacts of caregiving among families of children with medical complexity using their own words and perspectives, with the intent of expanding caregiver-centered perspectives when developing economic models.

Methods
This study was a secondary analysis of a qualitative study that was conducted to examine family management practices among caregivers of children with medical complexity and their social networks. Caregivers of children with medical complexity were recruited through a pediatric complex care clinic at an academic medical center in the mid-Atlantic region, United States. This study used inductive qualitative descriptive methods and a template to define features of the person impacted and to define the economic construct as either a direct or indirect (spillover) cost.

Results
A total of 20 caregivers were included in this study. Perspectives from the caregivers of children with medical complexity revealed several key themes: (1) time lost from employment, impacting the primary caregivers; (2) physical and mental health impacts, impacting the child themselves, siblings, and the primary caregivers; (3) impacts to leisure activities and self-care, impacting the child themselves, siblings, and the primary caregivers; and (4) impacts to the social network or social capital.

Conclusions
The themes described can be operationalized into inclusive family-centered models that represent the impacts of caregiving in the context of the family units of children with medical complexity. The use of qualitative methods to expand our development of quantitative economic models can be adapted to other populations where caregivers are involved in care. Caregivers can and should have an active voice in preference-based assessments that are operationalized in economic contexts to make them more inclusive.

International Registered Report Identifier (IRRID)
RR2-10.2196/14810
Acceptance, Safety, and Effect Sizes in Online Dialectical Behavior Therapy for Borderline Personality Disorder: Interventional Pilot Study
Authors: Vonderlin Ruben , Boritz Tali , Claus Carola , Senyüz Büsra , Mahalingam Saskia , Tennenhouse Rachel , Lis Stefanie , Schmahl Christian , Margraf Jürgen , Teismann Tobias , Kleindienst Nikolaus , McMain Shelley , Bohus Martin 
Published: November 2024

Background
The potential of telehealth psychotherapy (ie, the online delivery of treatment via a video web-based platform) is gaining increased attention. However, there is skepticism about its acceptance, safety, and efficacy for patients with high emotional and behavioral dysregulation.

Objective
This study aims to provide initial effect size estimates of symptom change from pre- to post treatment, and the acceptance and safety of telehealth dialectical behavior therapy (DBT) for individuals diagnosed with borderline personality disorder (BPD).

Methods
A total of 39 individuals meeting the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders [Fifth Edition]) criteria for BPD received 1 year of outpatient telehealth DBT at 3 sites in Germany and Canada. Effect size estimates were assessed using pre-post measures of BPD symptoms, dissociation, and quality of life. Safety was evaluated by analyzing suicide attempts and self-harm. Additionally, acceptance and feasibility, satisfaction with treatment, useability of the telehealth format, and the quality of the therapeutic alliance were assessed from both therapists’ and patients’ perspectives. All analyses were conducted on both the intention-to-treat (ITT) and according-to-protocol (ATP) samples.

Results
Analyses showed significant and large pre-post effect sizes for BPD symptoms (d=1.13 in the ITT sample and d=1.44 in the ATP sample; P<.001) and for quality of life (d=0.65 in the ITT sample and d=1.24 in the ATP sample). Dissociative symptoms showed small to nonsignificant reductions. Self-harm behaviors decreased significantly from 80% to 28% of all patients showing at least 1 self-harm behavior in the last 10 weeks (risk ratio 0.35). A high dropout rate of 38% was observed. One low-lethality suicide attempt was reported. Acceptance, feasibility, and satisfaction measures were high, although therapists reported only moderate useability of the telehealth format.

Conclusions
Telehealth DBT for BPD showed large pre-post effect sizes for BPD symptoms and quality of life. While the telehealth format appeared feasible and well-accepted, the dropout rate was relatively high. Future research should compare the efficacy of telehealth DBT with in-person formats in randomized controlled trials. Overall, telehealth DBT might offer a potentially effective alternative treatment option, enhancing treatment accessibility. However, strategies for decreasing drop-out should be considered.

Trial Registration
German Clinical Trials Register DRKS00027824; https://drks.de/search/en/trial/DRKS00027824
The Double Materiality Audit: Attestation of ESG Disclosures in Financial Statements
Authors: Appelbaum Deniz , Duan Huijue Kelly , Hu Hanxin , Sun Ting 
Published: November 2024

SYNOPSIS
Auditors are required to evaluate the reliability of financial numbers and potentially provide attestation of environmental, social, and governance (ESG) claims disclosed in financial statements. Double-materiality refers to assessing materiality from two aspects: first, the extent necessary for an understanding of the company’s financial position, and second, the ESG impact of the company’s activities on a broad range of stakeholders. For an audit, these are interconnected, meaning that despite their inherently nonfinancial nature, ESG factors are closely associated with financial outcomes and potential business risks. This research provides an understanding of such a double materiality audit by recognizing the role of external auditors regarding the interaction between a financial audit and ESG attestation and suggests an audit analysis roadmap that incorporates both quantitative and big ESG data. Specifically, it proposes extended audit procedures for data collection, verification, and analysis and highlights the ongoing challenges and opportunities.
JEL Classifications: G18; G30; G32; G38; M14; M41; M42; M48.
Content Adaptation in Online Streaming: How Streamers Utilize Game Updates to Improve Performance
Authors: Cheng Xu , Hsiao Shih-Hui , Lin Tony L. J. 
Published: November 2024

ABSTRACT
This study investigates the impact of distributed streams on viewer engagement. Using the difference-in-differences (DiD) method, viewer engagement is analyzed based on whether the stream contains game updates. The research dataset contains 2,063 videos randomly selected from 130 streamers from January to March 2024. This study investigates the relationship between streaming releases and viewer engagement by tracking daily viewer growth and controlling for variables such as streaming account age, number of past followers, and number of existing videos. Research results show that streaming media that reflects game updates can initially increase viewer engagement, a key performance indicator that supports decision making. This study contributes to the management accounting and accounting information system literature by emphasizing the need for management control systems to incorporate viewer engagement metrics. This integration aids in making informed decisions within the streaming industry and highlights the critical role of data analytics in improving performance.
Data Availability: Data will be made available on request.
JEL Classifications: L82; L86; M31; O33.
Bank Entry Barriers and Firms’ Risk-Taking
Authors: Basu Sudipta , Kaviani Mahsa S. , Maleki Hosein 
Published: November 2024

ABSTRACT
We study how nonfinancial firms’ operating risks change after bank competition increases. By exploiting the 1990s staggered regulatory reforms across U.S. states that allowed interstate banking and branching, we show that out-of-state bank entry was associated with lower borrower risk-taking on average. Large, profitable, safe, and geographically diversified firms signed up as new clients of large entrant banks, which offered larger and cheaper loans that reflected their higher efficiency and risk reduction through geographical diversification. We argue that these large banks could substitute for local relationship lending with more data collection from branches in multiple states. Firms that began borrowing from entrant banks increased capital expenditures and project-specific financing and kept R&D expenses stable but reduced R&D risk. Firms that continued borrowing from incumbent banks paid higher interest rates and increased their risk, suggesting that their credit access fell. States that opened up more had bigger changes in these outcomes.
Data availability: Data are available from the public sources cited in the text.
JEL Classifications: G21; G28; G32.
Intelligent Simulation Design and Application of Garment Digitization Based on Virtual Image Recognition Technology
Authors: Long Quanru , Ma Xinmin 
Published: October 2024

Abstract
Realizing the digital design of clothing is an effective means to improve the design efficiency and effect, for this reason, this paper designs a virtual simulation design assistance system based on virtual image recognition technology. Wavelet Fourier descriptor and LDA technology are utilized to extract features and decrease the dimensionality of the clothing style image, while the extreme learning machine is utilized as a classifier to categorize the clothing style image. Based on the classification results, a virtual simulation model of the garment is constructed and stored in the parts library for the convenience of designers to call and design at any time to complete the construction of the design assistance system. The application of this paper’s image recognition method results in an overall style recognition rate of 94.8%, an average recognition time of 3.2 milliseconds for each sample, and an average Fourier wavelet descriptor classification accuracy of 97.5%. The size error is controlled within ±2.5%, and the mean customer satisfaction scores for all the finished sweaters are higher than 2. This paper proposes a style map recognition method that achieves high accuracy, reduces time consumption, produces finished products with minimal size errors, and increases customer satisfaction with the designed styles.
Research on the Development Mode of Innovative Entrepreneurship Programs for College Students Driven by Internet Technology
Authors: Wu Meng , Wang Xia 
Published: October 2024

Abstract
The development of college students’ entrepreneurship in the context of the Internet and the current situation of social development are inextricably linked. The TF-IDF algorithm and literature combined to extract the influencing factors for college students’ innovation and entrepreneurship program development from four dimensions. The combination of the DEMATEL method and ISM method is used to quantitatively analyze the overall role relationship and the recursive hierarchical structure of the system elements and then identify the key elements affecting the development of college students’ innovation and entrepreneurship programs. Then, the qualitative comparative analysis method is used to summarize the common characteristics and combinations of conditions that lead to success in college students’ dual entrepreneurship projects driven by Internet technology in multiple cases. The results show that four factors at the school level occupy 3/5 of the explanatory position of the centrality degree, three factors at the national level are important outcome factors, and innovation and entrepreneurship team cultivation are the fundamental factors. There are a total of five paths, namely, environment-influenced (A1), experience-supported (A2), ideal-driven (B1), multiple-assisted (B2), and demand-oriented (B3), which contribute to the success of promoting college students’ innovative entrepreneurship programs under the Internet technology.
Selected issues regarding children’s rights in the war on terror with a particular focus on Syria
Authors: Matusiak-Frącczak Magdalena 
Published: November 2024

Abstract
The aim of the article is to analyse the legal situation of the children held in camps in northeast Syria. The situation in the camps is devastating and poses a threat to the children’s right to life as well as physical and mental integrity. The article explores whether the states of citizenship of these children exercise any jurisdiction over them, and if the answer is affirmative, to what extent they exercise this jurisdiction. Next, the research will focus on the question of whether the states of citizenship have the obligation to repatriate those children from Syria. To this aim, the status of these children as victims of human trafficking will be also examined. Lastly, the deliberations will focus on the policy of citizenship revocation that is applied by some states in terrorism combatting and it will be studied whether this policy can be applied to children in conformity with international law. It results from the analysis that states have obligations towards children placed in the Syrian camps being their nationals, especially an obligation to repatriate them and to enable their rehabilitation and reintegration.
Keefektifan Manajemen Risiko dan Strategi Investasi terhadap Profitabilitas pada Trading Forex
Authors: Lumbantobing Dionisius , Yusbardini Yusbardini 
Published: November 2024

Penelitian ini bertujuan untuk menguji pengaruh manajemen risiko dan strategi investasi terhadap profitabilitas dalam perdagangna forex. Penelitian ini bersifat prediktif dan menggunakan metode kuantitatif. Data dianalisis menggunakan Structural EEquation Modeling (SEM) dan optimasi Partial Least Square (PLS) dengan Smart PLS 4. Penelitian ini menggunakan manajemen risiko dan strategi investasi sebagai variabel independen, sedangkan profitabilitas perdagangan forex sebagai variabel dependen. Hasil penelitian ini menunjukkan bahwa manajemen risiko dan strategi investasi keduanya memengaruhi profitabilitas perdagangan foex, meskipun manajemen risiko memengaruhi profitabilitas perdagangan forex, namun tidak signifikan. Namun, strategi investasi, di sisi lain, memengaruhi profitabilitas perdagangan forex secara signifikan.

This study aims to examine the influence of risk management and investment strategy toward profitability of forex trading. This study is a predictive study which uses quantitative method. Data was analyzed by using Structural Equation Modeling (SEM) and optimization of Partial Least Square (PLS) with Smart PLS 4. This study examines risk management and investment strategy as independent variables, and profitability of forex trading as dependent variable. This study suggests that risk management and investment strategy influence profitability of forex trading, although risk management doesn’t influence profitability of forex trading significantly. However, investment strategy, on the other side, influences profitability of forex trading significantly.
THE MIXED UNIVARIATE CONTROL CHART EWMA AND CUSUM FOR FLAVOUR PRODUCTION QUALITY PROCESS MONITORING
Authors: Sari Surya Puspita , Maiyastri Maiyastri , Devianto Dodi 
Published: November 2024

A control chart is an important statistical technique used to monitor the average quality of a process or dispersion. Shewhart control chart is used to detect larger disturbances in process parameters. Along with the times, a more sensitive univariate control chart is created, namely EWMA and CUSUM. The control chart is developed into a combination as a Mixed EWMA-CUSUM control chart to detect smaller changes.Â The performance of the Mixed EWMA â€“ CUSUM control graph does not only rely on current observations, but also collects information from previous observations so as to provide a fast signal to detect out of control conditions.
KARAKTERISASI POHON DENGAN BILANGAN DOMINASI-LOKASI-METRIK TIGA
Authors: Zulfaneti Zulfaneti , Baskoro Edy Tri , Assiyatun Hilda 
Published: November 2024

Misalkan G = (V;E) adalah graf sederhana dan terhubung. Untuk suatuÂ himpunan R = fr1; r2; : : : ; rkg V dan v 2 V , representasi titik v terhadap R adalahÂ vektor r(vjR) = (d(v; r1); d(v; r2); : : : ; d(v; rk)) dimana d(v; r) menyatakan jarak titik vÂ dan titik r. Himpunan R disebut himpunan pembeda dari G jika semua titik di G memiliki representasi unik terhadap R. Himpunan D disebut himpunan dominasi dari G jikasetiap titik di G-D bertetangga dengan suatu titik v 2 D. Suatu himpunan dominasidan juga merupakan himpunan pembeda disebut himpunan dominasi-lokasi-metrik dariG. Kardinalitas dari himpunan dominasi-lokasi-metrik minimum dari G disebut bilangan dominasi-lokasi-metrik dari G. Semua graf orde n dengan bilangan dominasi-lokasi-metrik 1, 2, n-2 dan n-3 telah ditentukan secara lengkap. Dalam tulisan ini, kamimengkarakterisasi semua pohon dengan bilangan-dominasi-lokasi-metrik 3 dan secarakhusus membuktikan bahwa tidak ada pohon dengan bilangan-dominasi-lokasi-metriksama dengan dimensi metriknya.