bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE USE OF RIGISCAN® EXAMINATION IN DIAGNOSING PATIENTS WITH ERECTILE DYSFUNCTION IN JAKARTA
Authors: Basukarno Ari , Birowo Ponco , Tri Prasetyo Dimas , Rasyid Nur 
Published: August 2019

Objective: The aim of this study is to describe the characteristic of patients with Erectile Dysfunction (ED) and results of Nocturnal penile tumescence and rigidity (NPTR) based on Rigiscan® examination in patients with ED in Jakarta. Material & Methods: Descriptive-prospective study of patients with ED in Cipto Mangunkusumo Referral Hospital, Bunda General Hospital Jakarta, and ASRI-Siloam Urology Hospital are recorded during 2015. Patients’ age (in years), marital status (yes/no), duration of ED (in months), and International Index of Erectile Function-5 (IIEF-5) were recorded. NPTR examination were performed while patients were sleeping. Number of events, duration of each event (in minutes) as well as the rigidity (in percentage) and tumescence (in cm) were recorded. The elevation of tip and base penile circumference (in cm) during erection were also noted. Results: There were 34 patients who agreed to perform NPTR test. Most patients were married with the average age of 40.94 ± 10.81 years old. The duration of ED were varied from 5 to 96 months with average duration of 33.7 ± 44.34 months and IIEF-5 score was 6.38 ± 5.14. In general number of erections was 4 ± 3 with 23.4% of them had normal erection. The comparison between organic and psychogenic ED showed that the increment of circumference was significantly less in organic ED patients. Other parameters showed insignificant difference in statistical results. Conclusion: NPTR examination is an objective, effective, and easy-to-use measurement in order to differentiate between organic and psychogenic ED. One third of patients who complained with ED suffered from psychogenic ED and needed referral to other specialists.
URINARY STONE COMPOSITION ANALYSIS IN INDONESIAN POPULATION: A SINGLE MAJOR CENTRE ANALYSIS
Authors: Widyasmara Her Bayu , Birowo Ponco , Rasyid Nur 
Published: August 2019

Objective: To evaluate the urinary stone composition of Indonesian population. Material & Methods: This is a retrospective study analyzing total 277 urinary stone, obtained from urinary stone patient that underwent treatment in Cipto Mangunkusumo Hospital Jakarta in period 2000-2013. Results: Urinary stone disease is more common in male, with male : female ratio 1.8 : 1, with both in male and female patient, the incidence are highest at 51-60 years old. Calcium containing stone is predominant in this study with calcium oxalate as the most frequent stone with 61% overall, 43.7% in male and 17.3% in female and founded most frequent in 51-60 years old. Uric acid become the second most common stone after calcium containing stone with 9.0% overall, 6.5% in male and 2.5% in female. Infection associated stone such as struvite is 5.8% and Amonium urate 0.7%. In our study, struvite is founded more in male 3.6% than in female 2.2%. Cystine is a rare stone which is only founded 0.7%, in young age at 21-30 years old. Conclusion: Calcium oxalate is the most frequently stone type in our country as it is worldwide. This study revealed information of stone composition in Indonesian population, that could be beneficial for strategies and management to prevent urinary stone disease and recurrence.
THE INCIDENCE AND CORRELATION OF CHRONIC PROSTATITIS WITH PSA IN BPH PATIENT
Authors: Krisna Daniel Mahendra , Hariatmoko Hariatmoko , Pinzon R 
Published: August 2019

Objective: The aim of this study is to determine the incidence of incidental chronic prostatitis proven by biopsy in prostate enlargement patients and to correlate with Prostate Specific Antigen (PSA) level serum. Material & Methods: This was a retrospective study with cross-sectional method. All of the prostate enlargement subjects with urinary retention and treated by surgical therapy were taken into inclusion criteria. The patient with acute prostatitis proven by biopsy and uncompleted medical records were excluded. Statistical analysis used Spearman correlation test. Results: The mean values of age and PSA were 70.24 years and 27.2 ng/mL. The patients characteristic such as surgery waiting time were 81 patients in 1-3 days, the most common length of stay were 3 patients (4%) for 1-3 days. The most common biopsy result was Benign Prostatic Hyperplasia (BPH) in 55 patients (61.5%). 64 patients (70.3%) were treated by Trans Urethral Resection of Prostate (TURP) and 14 patients (9.9%) had secondary surgery. There was a correlation between chronic prostatitis with PSA levels in BPH patients (p=0.000). Conclusion: Chronic prostatitis is often found incidentally in BPH patients and affecting PSA serum level. The existence of chronic prostatitis in BPH may predict the progress of prostate growth.
METASTASIS AND LOCAL INVASION PATTERN OF BLADDER CANCER IN HASAN SADIKIN HOSPITAL
Authors: Mustafa Akhmad , Safriadi Ferry 
Published: August 2019

Objective: The aim of this study is to provide database about local invasion and metastasis pattern, as well as the disease characteristics of bladder cancer in Hasan Sadikin Hospital, Bandung. Material & Methods: Between January 2011 and December 2016 there were 321 cases of bladder cancer recorded in our hospital. Of all cases, 106 patients included in this study, with evident of local invasion or distant metastasis either radiologically (contrast abdominal pelvic CT scan) or pathologically. Results: The study group consist of 106 patients (86 men [81.7%], 20 women [28.3%]); with mean age of 56.78 ± 13.19 (4-76) years old. Histopathology findings of transitional cell carcinoma (TCC) consist of 82 (77.3%) patients and the atypical histology features group of 24 (22.7%) patients. Local invasion was found in 99 patients of 321 (30.8%), with the most common organ invasion to the prostate in male (n=38 [35.8%]). Lymph node metastasis were found in 47 patients (44.3%), with the most common nodal metastasis to obturator lymph nodes (n=21 [19.8%]). Distant metastasis was found in 24 patients (22.6%) with the most common site for distant metastasis was the liver (n=12 [11.3%]). In TCC group, 12 patients (63.1%) had a distant organ metastasis with nodal metastasis, whereas in atypical group, majority of the patients with distant organ metastasis (n=5 [83.3%]) had no lymph node involvement. Moreover, in transitional cell group, not all patient (n=17 [73.1%]) had local invasion of the tumor, while all patients with distant organ metastasis in atypical group (n=6 [100%]) had abdominal or pelvic wall invasion (cT4b). Conclusion: TCC is the most common pathology findings and with Prostate is the most common site for local tumor invasion. Obturator lymph nodes is the most common nodal metastasis and liver is the most common site for distant metastasis in bladder cancer.
THE EFFECT OF DEXAMETHASONE ON SPERMATOGONIUM AND SERTOLI CELL OF IPSILATERAL TESTIS IN UNILATERAL TESTICULAR TORSION WISTAR RAT
Authors: Efendi Ferdyan Rachmat , Renaldo Johan , Djojodimedjo Tarmono 
Published: August 2019

Objective: To investigate the effect of dexamethasone on spermatogonium and sertoli cell of ipsilateral testis in unilateral testicular torsion strain wistar rat. Material & Method: Experimental study with post-test only control group design. The present study was conducted on 30 Wistar male rats aged 10 – 12 weeks grouped into 5 groups. Group I was the normal/sham operation group (KN), group II was left testicular torsion for 4 hours group and followed by manual detorsion (K1), group III was left testicular torsion for 10 hours group and followed by manual detorsion (K2), group IV was left testicular torsion for 4 hours group and given dexamethasone 10 mg/kg body weight subcutaneously 30 minutes before manual etorsion (D1), and group V was left testicular torsion for 10 hours group and given dexamethasone 10 mg/kg body weight subcutaneously 30 minutes before manual detorsion. All rats had left orchidectomy 4 hours after detorsion. The number of spermatogonium and sertoli cells were counted in histological seminiferous tubular testis that have obtained Haematoxylin Eosin staining. Data were analyzed by ANNOVA followed by Post Hoc Tukey for spermatogonium and Kruskal Wallis followed by Mann Whitney test for sertoli cell. Differences were considered significant at p <0.05. Results: There was significant difference in the mean number of spermatogonium between K1 & D1 group. Otherwise, there was no significant difference in the mean number of spermatogonium between K2 & D2. There was significant difference in the mean number of Sertoli cells between K1 & D1 group, likewise that between K2 & D2 group. Conclusion: These results suggest that dexamethasone has protective effect in spermatogonium and sertoli cell in testicular torsion for 4 hours.
PREOPERATIVE INTRAVENOUS TRAMADOL FOR PERCUTANEOUS NEPHROSTOMY TO REDUCE INTRAOPERATIVE PAIN
Authors: Oetama Harris , Sihombing Aaron Tigor 
Published: August 2019

Objective: To evaluate the effect of additional preoperative intravenous tramadol for reducing intraoperative pain. Material & Methods: This study was a double blind randomized controlled study from April - June 2017 in Urology Department in Hasan Sadikin Hospital. Inclusion criteria were cervical cancer patients who were performed percutaneous nephrostomy. Exclusion criteria were patients with infection and pain before the procedure. Written informed consent was obtained from each patient and the study protocol was approved by the local human ethics committee. The subjects were randomly divided into 2 groups. Group A were given 100 ml dripped normal saline 1 hour before the procedure and intraoperative local anesthesia with lidocaine 2% and group B were given preoperative intravenous tramadol 100 mg dripped within 100 ml of normal saline 1 hour before the procedure and intraoperative lidocaine 2%. Visual Analogue Score (VAS) were used to evaluate the pain score. All calculation were done using SPSS version 20. Results: There were 60 cervical cancer patients who were performed percutaneous nephrostomy (29 patients in Group A and 31 patients in Group B). The mean age in group A was 48.86 ± 8.524 (years old) and the mean age in group B was 51.90 ± 6.76 (years old). The median VAS score in group A was 4, with the minimum score was 2.00, maximum score was 6.00. The median VAS score in group B was 2, with the minimum score was 0.00, maximum score was 4.00. In group A, 11 patients (18.3%) were mild pain, 16 patients (26.7%) were moderate pain, 2 patients (3.3%) were severe pain. In group B, 29 patients (48.3%) were mild pain, 2 patients (3.3%) were moderate pain, 0 patients (0.0%) were severe pain. Based on Mann-Whitney U test, there was a significant pain score reduction in group B compared to group A (p=0.0001). There were no significant differences in the prevalence or proportion of patients with nausea and vomiting in group A and B (10% and 12%, respectively). There were no other adverse events and other complications observed in both groups. Conclusion: Preoperative intravenous tramadol significantly reduced intraoperative pain in cervical patients who were performed percutaneous nephrostomy compare to those who were only given intraoperative local anesthesia.
ESWL EFFECTIVENESS FOR LOWER POLE KIDNEY STONES
Authors: Sholihin Riza Mazidu , Soetojo Soetojo , Muris Haviv 
Published: August 2019

Objective: To describe the profile of lower pole kidney stone patients who underwent Extracorporeal Shock Wave Lithotripsy (ESWL) and the clearance rate of ESWL for lower pole kidney stones at Soetomo General Hospital from 2012 to 2016. Material & Methods: This research design was analytical retrospective, lower pole kidney stone patients who underwent ESWL in Soetomo General Hospital from 2012 to 2016 who fulfill inclusion criteria become samples in this research. Samples were divided into two group, stone size <15 mm and 15-20 mm. Results: Total samples in this study were 128, consist of 81 males and 47 females. The age average was 48 ± 11.124. The stone size average was 9.5 ± 4.5 mm consisted of 109 patients with stone size <15 mm and 19 patients with stone size 15-20 mm. There were 119 single lower pole kidney stones and 9 multiple ones. From all patients, 77 patients (60.2%) were stones free and the rest (39.8%) were not. Stone free rate for lower pole kidney stones was higher in stone size <15 mm compared with 15-20 mm, 65.2% and 31.5% respectively. Statistical analysis with Chi-square showed significant ESWL clearance rate difference between lower pole kidney stone size <15mm group and 15-20 mm (p<0.05). Conclusion: ESWL was a safe option for lower pole kidney stones with high success rate. There was significant relationship between stone size and stone clearance rate. ESWL was effective for lower pole kidney stones size <15 mm.
THE EFFECT OF SILODOSIN AND SODIUM DICLOFENAC TO REDUCE PAIN AFTER DJ STENT REMOVAL IN SOETOMO HOSPITAL: DOUBLE-BLINDED RANDOMIZED-CONTROLLED TRIAL
Authors: Fathurrahman Hasroni , Soebadi Doddy M , Hakim Lukman 
Published: August 2019

Objective: To analyze, measure, compare, prove, and evaluate effectiveness of silodosin, diclofenac sodium, and the combination of both drugs in pain management after stent removal. Materials & Methods: Thirty-three patients were divided into three groups. Group I was given diclofenac Sodium 50 mg, group II was given silodosin 8 mg and group III was given the combination of diclofenac sodium 50 mg and silodosin 8 mg. The Wong Baker Pain Scale (WBPS) was assessed serially: two hours before the DJ stent removal, during DJ stent removal, and after the DJ stent removal (2 hours and 24 hours after). The data was analyzed by ANOVA and Kruskal-Wallis test. Results: In this study, 33 patients who underwent DJ stent removal were obtained. Wong Baker was presented in median (min-max) form. The WBPS study in each group did not differ statistically significant. Lowest WBPS during DJ stent removal was found in group III. Group III was better and statistically significant in reducing pain compared to group I and group II (p<0.05). WBPS two hours after removal in each group decreased and group III was better and statistically significant in reducing pain compared to group II, whereas group III compared to group I had an equivalent effectiveness. While the WBPS 24 hours after removal had the same value and did not differ significantly. No side effects or adverse events were found in the use of diclofenac sodium, silodosin, and their combinations. Conclusion: Single oral dose of diclofenac sodium combined with silodosin is effective to reduce pain after DJ stent removal.
EFFECT OF VITAMIN E (α-TOCOPHEROL) ADMINISTRATION ON SPERM MOTILITY AND MORPHOLOGY OF SPRAGUE DAWLEY STRAIN RATS AFTER CISPLATIN TREATMENT
Authors: Aditya Dimas Visa , Djojodimedjo Tarmono , Soebadi Doddy M 
Published: August 2019

Objective: To evaluate the protective effects of vitamin E α-tocopherol isomer against the toxicity of cisplatin on sperm motility and morphology in Sprague Dawley rats. Material & Methods: Twenty-four rats were grouped into four groups (n=6). The control group (CN) was injected with normal saline, second group (CP) was injected with cisplatin, the third group (P1) was injected with cisplatin and vitamin E 50 mg/kgBW for 7 weeks P.O, the fourth group (P2) was injected with cisplatin and vitamin E 200 mg/kgBW for 7 weeks P.O. Vitamin E was given from 3 weeks before cisplatin injection and 4 weeks following cisplatin injection. At 7th week, all the samples were undergoing bilateral orchidectomy. Vitamin E that being used in this study was α-tocopherol isomer. Results: Cisplatin decreased motility and morphology of spermatozoa significantly against controls. Vitamin E 50 mg/kgBW and 200 mg/kgBW significantly increased motility of spermatozoa (p<0.05) compared to those in the cisplatin group only. Vitamin E 50 mg/kgBW, and 200 mg/kgBW did not have a significant difference in spermatozoa motility compare to control groups. Vitamin E 50 mg/kgBW and 200 mg/kgBW could increase the spermatozoa morphology significantly compare to those cisplatin only group. Vitamin E 50 mg/kgBW, and 200 mg/kgBW did not have a significant difference in spermatozoa morphology compared to control groups. Conclusion: α-tocopherol 50 mg/kgBW and 200 mg/kgBW provided a same protective effect against spermatozoa damage especially in motility and morphology aspect due to cisplatin exposure. Therefore, in this study it was more recommended to use α-tocopherol in 50 mg/kgBW dose than 200 mg/kgBW.
THE ROLE OF VITAMIN E (α-TOCOPHEROL) ON TESTOSTERONE LEVEL IN SPRAGUE DAWLEY RATS FOLLOWING CISPLATIN TREATMENT
Authors: Rezia Dian Kartika , Hakim Lukman , Djatisoesanto Wahjoe 
Published: August 2019

Objective: To observe the difference of testosterone levels in adult male Sprague Dawley rats treated with combination of cisplatin and vitamin E compared to those treated with cisplatin only. Material & Methods: We used 24 adult male Sprague Dawley rats weight 200–300 grams and randomly assigned into 4 groups (n=6). Rats in negative control group (NC) were given intraperitoneal normal saline injection, while the positive control (PC) group were injected with cisplatin 5 mg/kgBW at the end of the 3rd week. Two other groups, P1 and P2, were injected with cisplatin 5 mg/kgBW and given vitamin E orally 50 mg/kgBW and 200 mg/kgBW, respectively. Cardiac blood was aspirated at the end of the 7th week and processed for analysis of testosterone levels. Results: We recorded a significantly lower testosterone levels in rats treated only with cisplatin 5 mg/kgBW (CP) compared to those in CN group (p=0.006), and those receiving combination of cisplatin and vitamin E 50 mg/kgBW (p=0.003) and 200 mg/kgBW (p=0.001). Though not significant, testosterone levels were higher in P2 group than in P1 group (p=0.702). Conclusion: Exposure to cisplatin can lower testosterone levels in white rats, and the administration of vitamin E gives protection against such effect.
EFFECT OF VITAMIN E (α TOCOPHEROL) ADMINISTRATION ON APOPTOSIS OF GERMINAL CELLS EPITHELIUM TESTIS IN SPRAGUE DAWLEY WHITE STRAIN RATS AFTER EXPOSED BY CISPLATIN
Authors: Nugroho Achmad , Djatisoesanto Wahjoe , Soebadi Doddy M 
Published: August 2019

Objective: To determine the differences of germinal epithelial testicular cell apoptosis in white Sprague Dawley strain rat that received combination of cisplatin and vitamin E compared to Sprague Dawley strain rat that received cisplatin only. Material & Methods: Twenty four Sprague Dawley rats were divided into 4 groups randomly. Group 1 Negative Control (NC) was given an injection of 1 cc 0.9% normal saline intraperitoneally as a placebo, group 2 Positive Control (PC) was given 5 mg/kgBW cisplatin intraperitoneally, group 3 (P1) was given cisplatin injection 5 mg/kgBW intraperitoneally + vitamin E (α tocopherol) 50 mg/kgBW by gavage and group 4 (P2) was given cisplatin injection 5 mg/kgBW intraperitoneally + vitamin E (α tocopherol) 200 mg/kgBW by gavage. Vitamin E (α tocopherol) was given 3 weeks before up to 4 weeks after cisplatin injection. Observation of the germinal epithelial cells apoptosis was carried out by calculating germinal epithelial cells apoptosis in the cross-section preparations of the seminiferous tubule which gave a positive reaction to the apoptag staining, using a 400x magnification light microscope. Results: Apoptosis on positive control (PC) group was different significantly compared to the negative control (NC) group (p<0.05). There was a significant difference in the apoptosis of germinal epithelial testicular cells in the cisplatin + vitamin E 50 mg/kgBW compared to the PC group (p<0.05). The cisplatin + vitamin E 200 mg/kgBW group; had a lower number of apoptosis compared to the cisplatin + vitamin E 50 mg/kgBW (p<0.05). Conclusion: Vitamin E provides a protective effect on decreasing the amount of apoptosis due to cisplatin exposure. The protective effect of vitamin E is dose-dependent.
COMPARISON OF EFFICACY AND SAFETY SILODOSIN 8 MG ONCE DAILY AND SILODOSIN 4 MG TWICE DAILY IN BPH PATIENTS WITH LUTS
Authors: Diansyah Ramzie Nendra , Renaldo Johan , Djatisoesanto Wahjoe , Hakim Lukman 
Published: August 2019

Objective: This study was aimed to compare the efficacy and side effect of silodosin 8mg once daily and silodosin 4mg twice daily in BPH-LUTS patients after 4 and 12 weeks. Material & Methods: Single blind randomized controlled trials in 60 male patients aged ≥45 years with BPH-LUTS from July 2017 to October 2017 was divided into groups who received 8mg of silodosin once daily and those who received 4mg of silodosin twice daily. Efficacy and adverse events were evaluated after 4 and 12 weeks of treatment. Results: There was no significant difference of mean age of the two groups was 67.93 ± 6.49 years and 69.07 ± 6.28 years respectively (p 0.49). Both doses of this drug decreased the International Prostate Symptom Score (IPSS) and significantly increased the maximum urinary flow (Qmax) (p<0.05) but there was no significant differences between the two groups (p>0.05). Ejaculation disorder was the most common side effect in all groups (6.7% and 5%) and there was no significant difference between the two groups (p>0.05). Conclusion: The administration of 8mg of once daily silodosin has similar efficacy as 4mg twice daily silodosin. There were no adverse events differences in the two groups. Ejaculation disorder is the most common adverse event of silodosin administration.
ANALYSIS OF DIFFERENCES DEGREE OF SEVERITY AND QUALITY OF LIFE OF BPH DIABETES WITH BPH NON-DIABETES PATIENTS
Authors: Kurnia Putra Prayoga Triyadi , Wahyudi Septa Surya , Novi M Ancah Caesarina 
Published: August 2019

Objective: Benign Prostatic Hyperplasia (BPH) is a benign tumor located in prostate caused by prostate cell that will continuously grows which covalent with the aging process and the dihidrotestosteron level (DHT) increase. Prostate Hyperplasia can stop the urethra pars prostatics and causesa clogging in the urine’s flow excretes from bladder. Lower Urinary Tract Symptomps (LUTS) is a bladder muscle compensation mechanism to excrete urine. Diabetes Mellitus (DM) is one of the risk factors of BPH. This research aimed to find the differences on the degree of severity and quality of life BPH DM with BPH non-DM. Material & Methods: This research was observational analytic with cross sectional design which done to 32 subjects that consist of 16 BPH-DM subjects and 16 BPH non-DM in Bina Sehat Hospital Jember, Paru Hospital Jember, and Bhayangkara Hospital Bondowoso which meet to the inclusion and exclusion criteria. Data acquired from lead interview result using International Prostate Symptoms Score (IPSS) questionnaire to evaluate the degree of severity and World Health Organization Quality of Life (WHOQOL-BREF) questionnaire to evaluate the quality of life. The data processing using Mann Whitney’s comparative test. Results: IPSS and physic domain, psychology and social had p value in a row 0.001; 0.000; 0.001; and 0.001. Conclusion: It showed that there was a meaningful difference between BPH DM with BPH non-DM. Environment domain had p value of 0.373. It showed the non-meaningful difference between BPH DM with BPH non-DM.