bluuebunny/crossref_metadata_2025_split huggingface dataset:
A homozygous TARS2 variant is a novel cause of syndromic neonatal diabetes
Authors: Donis Russell , Patel Kashyap A. , Wakeling Matthew N. , Johnson Matthew B. , Amoli Masha M. , Yildiz Melek , Akçay Teoman , Aspi Irani , Yong James , Yaghootkar Hanieh , Weedon Michael N. , Hattersley Andrew T. , Flanagan Sarah E. , De Franco Elisa 
Published: November 2024

AbstractAimsNeonatal diabetes is a monogenic condition which can be the presenting feature of complex syndromes. The aim of this study was to identify novel genetic causes of neonatal diabetes with neurological features including developmental delay and epilepsy.MethodsWe performed genome sequencing in 27 individuals with neonatal diabetes plus epilepsy and/or developmental delay of unknown genetic cause. Replication studies were performed in 123 individuals with diabetes diagnosed aged ≤1 year without a known genetic cause using targeted next‐generation sequencing.ResultsThree individuals, all diagnosed with diabetes in the first week of life, shared a rare homozygous missense variant, p.(Arg327Gln), in TARS2. Replication studies identified the same homozygous variant in a fourth individual diagnosed with diabetes at 1 year. One proband had epilepsy, one had development delay and two had both.Biallelic TARS2 variants cause a mitochondrial encephalopathy (COXPD‐21) characterised by severe hypotonia, epilepsy and developmental delay. Diabetes is not a known feature of COXPD‐21. Current evidence suggests that the p.(Arg327Gln) variant disrupts TARS2's regulation of the mTORC1 pathway which is essential for β‐cells.ConclusionsOur findings establish the homozygous p.(Arg327Gln) TARS2 variant as a novel cause of syndromic neonatal diabetes and uncover a role for TARS2 in pancreatic β‐cells.
Preparation of Cf/Si3N4 composites based on vat photopolymerization combined with precursor infiltration and pyrolysis
Authors: Wang Xuye , Li Shan , Duan Wenyan , Li Yalin , Liu Bingshan , Wang Gong , Cui Congcong , Li Wei , Chen Fei 
Published: November 2024

AbstractThe development of vat photopolymerization (VPP) 3D printing technology has created the conditions for the fabrication of complex structured Si3N4 ceramics. However, Si3N4 ceramics produced through VPP often lack sufficient mechanical properties, which limiting their applications. This study introduces short carbon fibers (Cf) into the VPP‐Si3N4 ceramics, combined with the polymer infiltration and pyrolysis (PIP) process, to prepare Cf/Si3N4 composites. The effect of Cf content on slurry preparation, green part printing, and mechanical properties of the Cf/Si3N4 composites was systematically investigated. The results indicate that Cf significantly enhances the mechanical properties of Cf/Si3N4 composites. At 6 wt.% Cf content, the samples exhibit the highest strength and fracture toughness, reaching 183.2 MPa and 6.2 MPa·m1/2, respectively, representing increases of 29.7% and 92.3% compared to samples without Cf. The improvement in mechanical properties is partly due to the ‘pinning effect’ of Cf, which enhances interlayer bonding strength in the printed green parts, positively impacting the overall mechanical properties of the composites. Additionally, inherent toughening mechanisms of Cf, such as fiber pull‐out, crack deflection, and crack bridging, further enhance the composite's mechanical properties. This study confirms the feasibility of using Cf to enhance the mechanical properties of VPP‐Si3N4 ceramic.
Ceramic membranes production using quartzite waste for treatment of domestic wastewater
Authors: França Simone A. S. , Santana Lisiane N. L. , Rodriguez Miguel A. , Menezes Romualdo R. , Arimatéia Rafaela R. , Lira Hélio L. 
Published: November 2024

AbstractIn this work, flat ceramic membranes were prepared using ball clay, quartzite waste, and corn starch as porogenic agent. The raw materials were characterized by X‐ray fluorescence (EDXRF) and X‐ray diffraction (XRD). The compositions were characterized by the following techniques: X‐ray diffraction and heating microscopy. The membranes were produced using the uniaxial pressing process and sintered at different temperatures (900, 1000 and 1100°C). Subsequently, they were characterized by X‐ray diffraction (XRD), linear shrinkage, apparent porosity, mercury porosimetry, flexural strength, and scanning electron microscopy (SEM). The membrane contents 20 wt.% of corn starch sintered at 1000°C was selected because it has porosity of 35%, pore size of 1.3 µm, flexural strength of 8.6 MPa and permeability of 203 L.h−1.m−2.bar−1. The microfiltration membrane was tested in the treatment of domestic laundry wastewater and showed good decreasing (>91%) of turbidity and clarification of the wastewater.
Competition between surficial and volumetric diffusion in sintering TiO2 polymorphs by molecular dynamics simulation
Authors: Li Jiang , Yang Haozhen , Yin Deqiang , Pi Wenli 
Published: November 2024

AbstractThe competition between surficial and volumetric diffusion during the sintering process for ceramic polymorphism at different sintering temperatures is worth deeply exploring. In the current work, various sintering cases of mixed TiO2 nanoparticles with rutile and anatase types were investigated and the effects of crystalline phase, sintering temperature, and particle size on the sintering process were systematically investigated. The difference in thermodynamic stability and surficial activity of the crystalline phase could promote the decomposition and densification of the nanoparticles. Comparing the mixed‐phase sintering process at different sintering temperatures, the results showed that the particle binding process at low temperature relied mainly on surficial diffusion, however, volumetric diffusion played a crucial role at high temperature. The internal occurrence of volumetric diffusion inhibited the surficial diffusion, resulting in a smaller diameter of the sintering neck and a different sintering rate. In the case of sintering three nanoparticles with rutile and anatase types, it could be found that the decomposition of nanoparticles is more uniform in mixed‐phase sintering at high temperatures and the sintering rate is not significantly influenced by the sintering temperature. This work demonstrates the advantage of a mixed‐phase sintering strategy for TiO2 nanoparticles, which could provide insight into ceramic materials with polymorphism.
Fabrication of BiScO3–PbTiO3/epoxy 1–3 piezoelectric composites for high‐temperature transducer applications
Authors: Hu Liqing , Jin Ruoqi , Qiu Chenyu , Ren Xiaodan , Wang Sanhong , Xu Zhuo , Tian Hua , Li Xiaotian , Yan Yongke 
Published: November 2024

Abstract1–3 piezoelectric composites are widely used in piezoelectric ultrasonic transducers due to their high thickness electromechanical coupling factor. However, the applications of the composites in high‐temperature fields are limited by the low heat resistance of both the piezoelectric and polymer phases. To tackle this, we designed and fabricated the BiScO3–PbTiO3/epoxy high‐temperature 1–3 piezoelectric composites. These composites exhibit a high thickness electromechanical coupling factor kt of 63%, a large piezoelectric coefficient d33 of 470 pC/N, and a pure thickness vibration mode. Furthermore, we fabricated a high‐temperature transducer based on the BiScO3–PbTiO3/epoxy 1–3 composites. The bandwidths of the composites measured in water and silicone oil (30% and 23%, respectively) are approximately 1.65 times greater than those of monolithic piezoelectric ceramics (18% and 14%, respectively). The bandwidth of the transducer can be increased to 78% by adding a porous alumina backing layer, with the working temperature reaching up to 300°C. The results indicate that the BS–PT/epoxy 1–3 composite is a potential candidate for high‐temperature transducer applications.
Nursing practice of the prevention and control guidelines for vascular catheter‐related bloodstream infections
Authors: Yang Qingyan , Li Jingna , Ai Xiaoyan , He Ruijing , Yan Bing , Cui Zhiqiang , Liang Tao 
Published: November 2024

AbstractObjectiveTo apply the Ottawa Model of Research Use to translate the Guidelines for the Prevention and Control of Vascular Catheter‐Associated Bloodstream Infections.MethodsThe Ottawa model of research use is used to provide a framework and guidance. This study was organized by the Nursing Department of the Affiliated Hospital of Hebei Engineering University, and the Intravenous Therapy Group was responsible for the implementation of the study. The hospital's intravenous therapy administrators, members of the sedation team, and specialist nurses will be organized to evaluate the importance, exactness, and clinical practicability of 34 entries. Twelve clinical departments and intravenous therapy clinics with a high number of central venous catheters were used as sites for translating evidence from this project. The evidence‐based team assessed the practice environment, potential practitioners, and clinical status of clinical translation of evidence through symposia, review of relevant systems, operational procedures, on‐site inspections, and questionnaires. They compare evidence with existing processes and decide on change strategies.ResultsBefore and after the application of the evidence, there was a significant increase in the knowledge, belief, and behavior of healthcare workers on CLABSI prevention and control, especially in the acquisition of related knowledge (χ2 = 26.648 p < 0.001). The associated implementation rate was also significantly improved, with a significant decrease in CLABSI incidence from 0.29 per 1000 to 0.11 per 1000 (χ2 = 8.625 p = 0.004). The assessment of the integration of issues showed that 8 aspects, including workflow, knowledge mastery, monitoring reports, and aseptic operations, do not meet the qualified standards.ConclusionThrough this clinical change, a perfect prevention and control system has been established, and the level of knowledge, belief, and behavior of medical staff in preventing CLABSI has been improved, while the incidence of CLABSI has been reduced.
A new species of Hypancistrus Isbrücker & Nijssen 1991 (Loricariidae, Siluriformes) from the rapids of the middle Rio Tocantins
Authors: Araújo Felipe , Ferreira Marlon , Monteiro Iann , Wosiacki Wolmar 
Published: November 2024

AbstractThe Hypancistrus genus is recognized in the Río Orinoco basin and Rio Xingu in the Guiana and Brazilian Shields, respectively. Some of its species are important in ornamental fishing. Despite this significance, many other undescribed species are still awaiting to be named. Here we describe a new species of Hypancistrus found on bedrock in the Rio Tocantins, representing an extension of the distribution of the genus. Also, a multigene phylogeny is presented to evaluate the taxonomic position of this species concerning congeners. The new species differs from all congeners by (1) hypertrophied odontodes on cheeks reaching beyond the cleithrum, (2) a supraoccipital crest conspicuously elevated, (3) a supraorbital crest slightly convex, (4) oblique bars on the anterior part of the body, (5) a dark E‐shaped mark on the snout, (6) three oblique dark bars on the anterior part of the body and horizontal vermicular bars from the pectoral girdle to the posterior insertion of the dorsal fin, (7) a thin light gray bar on the posterior of the head extending across the branchial opening, (8) a tan background color, (9) a developed suspensorium with a diminished appendix in the metapterygoid, and (10) a dentary plate robust significantly fused with the angulo‐articular bone. The molecular phylogenetic results show the new species forming a group with Hypancistrus zebra (Brazilian Shield—Rio Xingu) as a clade, a sister group of a monophyletic group consisting of all congeners from the Río Orinoco.
Comparison of outcomes of labor induction with dinoprostone vaginal insert (PROPESS) and double balloon cook catheter in term nulliparous pregnancies
Authors: Li Shiyu , He Hua , Zheng Wenpei , Liu Jing , Chen Chaoli 
Published: November 2024

AbstractObjectiveThis retrospective study aimed to compare the outcomes of dinoprostone vaginal insert (PROPESS) and double balloon cook catheter (DBC) in term nulliparous pregnancies.Materials and MethodsA total of 1682 cases were enrolled, all of which were divided into two groups: PROPESS and DBC. The primary outcomes were rate of vaginal delivery (VD) and cesarean section (CS) and successful VD within 24 h and CS indications; the secondary outcomes were labor duration, oxytocin augmentation, complications during labor, maternal/neonatal outcomes, and predictors of successful VD within 24 h.ResultsThere was no statistical difference in the rates of VD between the PROPESS group (73.74%) and the DBC group (77.73%) (p = 0.36). The VD rate within 24 h was significantly higher in PROPESS group than in the DBC group (55.45% vs. 38.43%, p < 0.001). The occurrence of nonreassuring fetal heart rate (NRFHR) patterns was higher in the CS indications of the PROPESS group than in the DBC group (56.86% vs. 37.81%, p < 0.001). The oxytocin augmentation was significantly lower in the PROPESS group than in the DBC group (52.79% vs. 94.9%, p < 0.001). The incidence of chorioamnionitis was significantly higher in the DBC group as compared with PROPESS group (4.36% vs. 1.34%, p < 0.001), while neonatal outcomes were comparable between the two groups. PROPESS (p < 0.001, odds ratio [OR] 2.478, 95% confidence interval [CI] 1.718–3.574), oxytocin augmentation (p < 0.001, OR 32.759, 95% CI 20.654–51.958), and amniotomy (p = 0.016, OR 1.897, 95% CI 1.331–2.704) were predictors of VD within 24 h.ConclusionThe effectiveness of delivery was comparable between the two groups. The PROPESS group resulted in a high successful VD rate within 24 h, although accompanied by NRFHR occurrence. Two cases with fetal presentation change (cephalic to breech) and four cases with umbilical cord prolapse were observed in the DBC group. PROPESS, oxytocin augmentation, and amniotomy were associated with VD interval within 24 h.
Propaganda and thought work in the Mao era: Absoluteness, sharp transitions, and political instability
Authors: Li Haoguang 
Published: November 2024

AbstractThis paper elucidates the reasons behind Deng Xiaoping's initiation of political reform from a propaganda perspective by examining the features of Mao's propaganda and thought work and their implications for the Chinese Communist Party, analyzing cases such as the “Two‐Hundred Policy,” the “Anti‐Rightist Campaign,” propaganda campaigns related to the USSR, and the transformation of Lin Biao's image. It argues that Mao's propaganda and thought work, characterized by their absoluteness and sharp transitions, were detrimental to the stability of the communist regime. These characteristics led to widespread indifference, distrust, and even resistance toward the Chinese Communist Party among the Chinese populace since the late Mao era. China had entered a post‐trust era, marked by a growing tendency among the populace to preemptively view official messages as untrustworthy. To restore the party's credibility, Deng Xiaoping initiated reforms in propaganda and thought work to address these shortcomings.
Characterisation of the Phenotypic Reaction of Brazilian Soybean Genotypes to Sclerotinia sclerotiorum Under Controlled Conditions
Authors: Borges A. B. , Huzar‐Novakowiski J. , Pasquali M. , Baretta D. 
Published: November 2024

ABSTRACTWhite mould is a disease caused by the fungus Sclerotinia sclerotiorum, and it is considered one of the most devastating diseases in soybean crops, causing huge losses in productivity. In this study, we aimed to contribute to the genetic control of this disease by characterising the phenotypic reaction of 67 Brazilian soybean genotypes to S. sclerotiorum under controlled conditions. Plants were artificially inoculated with mycelium discs when they reached the four‐node phenological stage. Symptoms of white mould developed in all soybean genotypes. The resistance reaction was characterised by measuring the length of lesions on the main stem at 7 days after inoculation. Of the 67 genotypes evaluated, nine showed greater resistance to S. sclerotiorum, including 17S‐01443‐L8, 16S‐00630‐L4, GER_00003, 13S‐00001‐L2/FPS 2457 RR, BMX Torque I2X, P95Y02 IPRO, 17S‐00842‐L5, HO Pirapó IPRO and TMG 2359 IPRO. Twenty‐three genotypes showed an intermediate response, while 35 genotypes showed greater susceptibility to S. sclerotiorum. Further studies should be conducted under field conditions with the soybean genotypes that showed greater resistance response to S. sclerotiorum under controlled conditions.
Understanding the longitudinal trends (2005–2018) and multilevel risk factors of complementary feeding in Guinea
Authors: Schwendler Teresa R. , Shakya Evaniya , Kodish Stephen R. , Na Muzi 
Published: November 2024

AbstractThis study aimed to define complementary feeding trends in Guinea from 2005 to 2018 and complementary feeding risk factors at the individual, household, and community levels. Data from 2005 to 2018 demographic health surveys (DHS) and Multiple Indicator Cluster Surveys were used to describe complementary feeding trends in Guinea. The most recent DHS was used to examine complementary feeding risk factors at the individual, household, and community levels. Complementary feeding indicators including introduction to complementary foods (INTRO), minimum dietary diversity (MDD), minimum meal frequency (MMF), and minimum acceptable diet (MAD) were calculated based on the 2010 World Health Organisation guidance. Multivariate logistic regressions were used to identify significant risk factors (p < 0.05). Since 2005, there has been a marginal increase in MDD and MAD, but a decrease in INTRO and MMF. The 2018 DHS survey revealed various complementary feeding risk factors. At the individual level, travelling 1–60 min to get water was associated with decreased odds of meeting INTRO, while iron supplementation and maternal education were associated with increased odds of meeting MMF and MDD, respectively. Routine vitamin A supplementation, fever in the past 2 weeks, and low birth weight were associated with increased odds of meeting MAD. At the household level, being in a lower wealth quintile was associated with decreased odds of meeting MDD and MAD. National and subnational programmes and policies designed to improve infant and young child diets may consider tailored approaches that address the specific indicators and risk factors associated with poorer diets in this Guinean context.
What Predicts Gene Flow During Speciation? The Relative Roles of Time, Space, Morphology and Climate
Authors: Streicher Jeffrey W. , Lambert Shea M. , Méndez de la Cruz Fausto R. , Martínez‐Méndez Norberto , García‐Vázquez Uri Omar , Nieto Montes de Oca Adrián , Wiens John J. 
Published: November 2024

ABSTRACTThe processes that restrict gene flow between populations are fundamental to speciation. Here, we develop a simple framework for studying whether divergence in morphology, climatic niche, time and space contribute to reduced gene flow among populations and species. We apply this framework to a model system involving a clade of spiny lizards (Sceloporus) occurring mostly in northeastern Mexico, which show striking variation in morphology and habitat among closely related species and populations. We developed a new time‐calibrated phylogeny for the group using RADseq data from 152 individuals. This phylogeny identified 12 putative species‐level clades, including at least two undescribed species. We then estimated levels of gene flow among 21 geographically adjacent pairs of species and populations. We also estimated divergence in morphological and climatic niche variables among these same pairs, along with divergence times and geographic distances. Using Bayesian generalised linear models, we found that gene flow between pairs of lineages is negatively related to divergence time and morphological divergence among them (which are uncorrelated), and not to geographic distance or climatic divergence. The framework used here can be applied to study speciation in many other organisms having genomic data but lacking direct data on reproductive isolation. We also found several other intriguing patterns in this system, including the parallel evolution of a strikingly similar montane blue–red morph from more dull‐coloured desert ancestors within two different, nonsister species.
Effect of infusion line connection and infusion line characteristics on start‐up fluid delivery from syringe infusion pumps used for microinfusion
Authors: Weiss Markus , Wendel‐Garcia Pedro David , Cannizzaro Vincenzo , Kleine‐Brueggeney Maren 
Published: November 2024

AbstractBackgroundConnecting an infusion line to a closed stopcock results in pressurization of fluid within the syringe infusion pump assembly leading to flow irregularities when opening the stopcock and activating the pump.AimsIt was the purpose of this study to assess the extent of pressurization under different conditions and its impact on start‐up fluid delivery.MethodsIntraluminal pressures and start‐up fluid delivery at 1 mL/h flow rate were assessed with connection of the infusion line 1 min (delayed connection) or immediately after purging (immediate connection) using two different infusion lines made from polyvinylchloride (PVC) or polyethylene (PE).ResultsDelayed connection resulted in an increase of intraluminal pressures from zero to 5.1 [4.5 to 5.7] mmHg with the PVC line and from zero to 47.1 [44.8 to 49.3] mmHg with the PE line (mean difference 42.0 [95% CI 39.3–44.7] mmHg; p < .0001). Immediate connection resulted in an increase of intraluminal pressures from zero to 44.3 [41.8–46.8] mmHg with the PVC line and from zero to 61.3 [57.2–65.4] mmHg with the PE line (mean difference 17.0 [95% CI 11.8–22.2] mmHg; p < .0001). The increase in intraluminal pressures was significantly higher with PE lines for both delayed and immediate connection when compared to the PVC lines (mean difference 29.5 [95% CI 19.3–39.7] mmHg; p < .0001). Related fluid volumes delivered at 10 s and 360 s after starting the pump ranged from −252% to 1321% (10 s) of expected infusion volumes and from 59% to 129% (360 s), respectively.ConclusionsBoth, timing of infusion line connection after purging and infusion line characteristics considerably affect intraluminal pressures and start‐up fluid delivery when connecting a new syringe infusion pump assembly to a closed stopcock. Consecutive alterations in drug administration can have considerable hemodynamic consequences when dealing with catecholamine infusions in critically ill patients.