bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enabling factors and barriers to the sustainability and scale-up of drowning reduction interventions in Vietnam: a qualitative assessment
Authors: Jagnoor Jagnoor , Christou Aliki , Pham Cuong , Ivers Rebecca Q , Nguyen Ha 
Published: June 2019

BackgroundVietnam has some of the highest rates of drowning deaths in the Western Pacific Region, particularly among children aged 19 years or younger. Several policies aimed at drowning prevention have been developed over the last decade; however, despite policy support, generally these have not been sustained beyond a pilot phase or have been limited to small geographical regions. The present study aims to explore barriers and facilitators for sustainability and scale-up of drowning prevention initiatives in Vietnam, identifying ways forward for future implementation.MethodsThis was a qualitative study using semistructured indepth interviews with key stakeholders (n=12) engaged in drowning prevention in Vietnam. The Framework Method was used to analyse the data drawing on Schell’s theoretical framework for public health programme sustainability. The Framework Method is most commonly used for the thematic analysis of semistructured interview transcripts, particularly as the data were fairly homogeneous.ResultsFour key factors were identified that facilitated implementation of drowning reduction activities in Vietnam. Strong political support at all levels, underpinned by policy; effective partnerships with the community; widespread communication; and programme adaptation to local contexts and application of innovative approaches, for example, strengthening organisational capacity in limited resource settings, were the key enablers. Barriers include the instability of the funding sources; inadequate programme evaluations to generate evidence of effectiveness and lack of consistent and timely data collection; and insufficient strategic planning for long-term implementation of drowning prevention interventions.ConclusionEnsuring the sustainability and scale-up of drowning prevention programmes in Vietnam requires a continued focus on enablers such as on community engagement, communication activities and partnership approaches, and importantly concerted efforts to mobilise resources for continued long-term funding, improvements in planning and intersectoral coordination, and ensuring that future programmes are robustly evaluated for effectiveness.
Microsatellite instability diagnosis using the fully automated Idylla platform: feasibility study of an in-house rapid molecular testing ancillary to immunohistochemistry in pathology laboratories
Authors: Samaison Laura , Grall Mélanie , Staroz Frédéric , Uguen Arnaud 
Published: June 2019

AimTo study the performances of the Idylla MSI Assay in the diagnosis of microsatellite instability (MSI) or microsatellite stability (MSS).MethodsWe selected 12 tumour samples previously tested for MSI focusing on cases with discrepant results between MLH1, PMS2, MSH2 and MSH6 immunohistochemistry and microsatellite molecular analyses (five cases) or doubtful immunohistochemistry (two cases). Idylla MSI Assay was compared with retrospective immunohistochemistry and molecular results.ResultsIdylla MSI Assay showed an almost perfect concordance with microsatellite analysis results previously obtained (only one case with not fully conclusive analysis due to sample exhaustion). The full molecular analysis took less than 150 min per sample and revealed no mutation in any of the seven microsatellite sequences in five MSS samples and four to six mutated ones in seven MSI-High samples.ConclusionAt the era when the determination of MSI/MSS status is becoming important for rapid treatment choices, the Idylla MSI Assay consists of a valuable easy-to-perform diagnostic tool that allows, complementary to MLH1, PMS2, MSH2 and MSH6 immunohistochemistry, the diagnosis of MSI/MSS status in a single day.
Shift of estuarine type in altered estuaries
Authors: Shin Hyun-Jung , Lee Guan-hong , Kang KiRyong , Park Kyeong 
Published: June 2019

Abstract
To better understand the alteration of the estuarine circulation caused by estuarine dams, four major Korean estuaries were classified by using the Hansen and Rattray stratification–circulation classification scheme. The stratification and circulation parameters were calculated for both discharge and no-discharge periods from the tidally averaged salinity and velocity data obtained from these four Korean estuaries. The estuarine types of the altered Korean estuaries were compared with the previous results for natural estuaries in other countries of similar magnitude in tidal range, water depth, and discharge. This comparison revealed that the estuarine types of the altered Korean estuaries have been shifted from a partially mixed to a well-mixed type (Nakdong River Estuary), from a partially mixed to a coastal bay or a fjord type (Yeongsan River Estuary), and from a well-mixed to a well-mixed type with less tidal modulation (Geum River Estuary). The controlling factors that determined the type in natural estuaries were tide, discharge, and water depth, whereas for altered estuaries, they were the controlled river discharge and water depth. The different estuarine dam gate types with their different modes of operation (surface or bottom discharge) played an important role in the mixing and circulation of the altered estuaries.
Single production of vector-like top partner in the Wb channel at eγ collision in the LHT model
Authors: Yang Guang , Yang Bingfang , Hou Biaofeng , Bi Hengheng 
Published: June 2019

In the framework of the littlest Higgs Model with T-parity (LHT), we investigate the single production of vector-like top partner [Formula: see text] decaying to [Formula: see text] in the leptonic channel at the high energy [Formula: see text] collision. We utilize the polarized electron beam and photon beam to enhance the signal and propose a search strategy by performing a detector simulation. On the basis of the current limits from the precision electroweak data and Higgs data, we find that the top partner mass can be excluded up to 1350 (1380) GeV with integrated luminosity of 1000 fb[Formula: see text] and 1400 (1470) GeV with integrated luminosity of 3000 fb[Formula: see text] for the [Formula: see text] TeV (2.4 TeV) at the [Formula: see text] level. If the center-of-mass energy can be improved to 3.0 TeV, the limits on the top partner mass will reach 1450 (1550) GeV with integrated luminosities of 1000 (3000) fb[Formula: see text].
WearBreathing
Authors: Liaqat Daniyal , Abdalla Mohamed , Abed-Esfahani Pegah , Gabel Moshe , Son Tatiana , Wu Robert , Gershon Andrea , Rudzicz Frank , Lara Eyal De 
Published: June 2019

Respiratory rate is a vital physiological signal that may be useful for a multitude of clinical applications, especially if measured in the wild rather than controlled settings. In-the-wild respiratory rate monitoring is currently done using dedicated chest band sensors, but these devices are specialized, expensive and cumbersome to wear day after day. While recent works have proposed using smartwatch based accelerometer and gyroscope data for respiratory rate monitoring, current methods are unreliable and inaccurate in the presence of motion and have therefore only been applied in controlled or low-motion settings. Thus, measuring respiratory rate in the wild remains a challenge.
We observe that for many applications, having fewer accurate readings is better than having more, less accurate readings. Based on this, we develop WearBreathing, a novel system for respiratory rate monitoring. WearBreathing consists of a machine learning based filter that detects and rejects sensor data that are not suitable for respiratory rate extraction and a convolutional neural network model for extracting respiratory rate from accelerometer and gyroscope data. Using a diverse, out-of-the-lab dataset that we collected, we show that WearBreathing has a 2.5 to 5.8 times lower mean absolute error (MAE) than existing approaches. We show that WearBreathing is tunable and by changing a single threshold value, it can, for example, deliver a reading every 50 seconds with a MAE of 2.05 breaths/min or a reading every 5 minutes with an MAE of 1.09 breaths/min. Finally, we evaluate power consumption and find that with some power saving measures, WearBreathing can run on a smartwatch while providing a full day's worth of battery life.
Adherence to the World Cancer Research Fund/American Institute for Cancer Research 2018 Recommendations for Cancer Prevention and Risk of Colorectal Cancer
Authors: Petimar Joshua , Smith-Warner Stephanie A. , Rosner Bernard , Chan Andrew T. , Giovannucci Edward L. , Tabung Fred K. 
Published: June 2019

AbstractBackground:The World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) 2018 diet, nutrition, and physical activity recommendations aim to reduce cancer risk. We examined adherence to the WCRF/AICR recommendations and colorectal cancer risk in two prospective cohorts.Methods:We followed 68,977 women in the Nurses' Health Study and 45,442 men in the Health Professionals Follow-up Study from 1986 until 2012. We created cumulatively averaged WCRF/AICR scores using updated diet, adiposity, and physical activity data from questionnaires, and used Cox regression to estimate sex-specific HRs and 95% confidence intervals (CI) for incident colorectal cancer.Results:We documented 2,449 colorectal cancer cases. Men in the highest quintile of the WCRF/AICR lifestyle score had a lower risk of colorectal cancer compared with those in the lowest quintile (HRQ5vsQ1 = 0.64; 95% CI, 0.52–0.77). The result was weaker in women (HRQ5vsQ1 = 0.86; 95% CI, 0.72–1.02; Pheterogeneity by sex = 0.006). When analyzing the diet recommendations alone, we similarly observed stronger inverse associations in men (HRQ5vsQ1 = 0.74; 95% CI, 0.61–0.90) compared with women (HRQ5vsQ1 = 0.93; 95% CI, 0.77–1.12; Pheterogeneity by sex = 0.06). In men, the lifestyle score was more strongly inversely associated with risk of distal colon cancer compared with proximal colon or rectal cancer (Pcommon effects = 0.03); we did not observe significant differences between anatomic locations in women.Conclusions:The 2018 WCRF/AICR cancer prevention recommendations are associated with lower colorectal cancer risk in men, with weaker results in women.Impact:Consideration of adiposity and physical activity in conjunction with diet is important for colorectal cancer prevention.
Adherence to the Mediterranean Diet and Risks of Prostate and Bladder Cancer in the Netherlands Cohort Study
Authors: Schulpen Maya , van den Brandt Piet A. 
Published: June 2019

Abstract

Background:
Prostate cancer and urinary bladder cancer are frequently occurring cancers with few risk factors identified. We examined the relation of Mediterranean diet (MD) adherence with risks of prostate and bladder cancer in the Netherlands Cohort Study (NLCS).

Methods:
Data were available for 58,279 men and 62,573 women, who completed a baseline questionnaire on diet and other cancer risk factors. Multiple MD scores, including the alternate Mediterranean diet score without alcohol (aMEDr), were calculated to assess MD adherence. After 20.3 years of follow-up, 3,868 prostate cancer cases (advanced: 1,256) and 1,884 bladder cancer cases could be included in multivariable Cox proportional hazards analyses.

Results:
aMEDr was not associated with advanced prostate cancer risk [hazard ratio (HR)per 2-point increment (95% confidence interval, 95% CI) = 1.06 (0.96–1.17)]. In contrast, higher aMEDr values were associated with a significantly increased risk of nonadvanced prostate cancer (Ptrend = 0.04). For bladder cancer risk, no association was observed with aMEDr [HRper 2-point increment (95% CI) = 1.00 (0.92–1.09)]. Absolute scores based on the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) dietary recommendations were not associated with prostate or bladder cancer risk.

Conclusions:
MD adherence, measured by aMEDr or other MD scores, was not associated with decreased risks of advanced prostate cancer and bladder cancer in the NLCS. Higher levels of care-seeking behavior, screening attendance, and prostate cancer awareness in higher educated men with healthier lifestyles could potentially explain the positive associations observed for nonadvanced prostate cancer risk.

Impact:
MD adherence does not seem to reduce the risk of (advanced) prostate cancer or bladder cancer.
TRIB3 Stabilizes High TWIST1 Expression to Promote Rapid APL Progression and ATRA Resistance
Authors: Lin Jian , Zhang Wu , Niu Li-Ting , Zhu Yong-Mei , Weng Xiang-Qin , Sheng Yan , Zhu Jiang , Xu Jie 
Published: June 2019

Abstract

Purpose:
The resistance to differentiation therapy and early death caused by fatal bleeding endangers the health of a significant proportion of patients with acute promyelocytic leukemia (APL). This study aims to investigate the molecular mechanisms of all-trans retinoic acid (ATRA) resistance and uncover new potential therapeutic strategies to block the rapid progression of early death.

Experimental Design:
The important role of TWIST1 in APL leukemogenesis was first determined by gain- and loss-of-function assays. We then performed in vivo and in vitro experiments to explore the interaction of TWIST1 and TRIB3 and develop a potential peptide-initiated therapeutic opportunity to protect against early death and induction therapy resistance in patients with APL.

Results:
We found that the epithelial–mesenchymal transition (EMT)-inducing transcription factor TWIST1 is highly expressed in APL cells and is critical for leukemic cell survival. TWIST1 and TRIB3 were highly coexpressed in APL cells compared with other subtypes of acute myeloid leukemia cells. We subsequently demonstrated that TRIB3 could bind to the WR domain of TWIST1 and contribute to its stabilization by inhibiting its ubiquitination. TRIB3 depletion promoting TWIST1 degradation reverses resistance to induction therapy and improves sensitivity to ATRA. On the basis of a detailed functional screen of synthetic peptides, we discovered a peptide analogous to the TWIST1 WR domain that specifically represses APL cell survival by disrupting the TRIB3/TWIST1 interaction.

Conclusions:
Our data not only define the essential role of TWIST1 as an EMT-TF in patients with APL but also suggest that disrupting the TRIB3/TWIST1 interaction reverses induction therapy resistance and blocks rapid progression of APL early death.
See related commentary by Peeke and Gritsman, p. 6018
O ensino de “projeto” nos primórdios da arquitetura: o papel da mimesis
Authors: Kotchetkoff Julia 
Published: June 2019

O artigo especula sobre as origens do ensino do ato de criar arquitetura. Para tal tarefa, parte-se do pressuposto de que poderiam ser elencados dois momentos iniciais para a atividade arquitetônica – um primitivo, vinculado aos primeiros processos construtivos e às escolhas vinculadas a estes; e outro disciplinar, inaugurado junto à separação da figura da pessoa que constrói daquela que planeja a construção. Observando este primeiro período no qual não havia de fato “projeto”, a pesquisa encontra no mecanismo da mimesis, ou da imitação da natureza, aresposta para a origem do ensinar do fazer arquitetônico.
Desenhar para compreender e lembrar: a arquitetura portuguesa no traço de Lúcio Costa
Authors: Pessôa José Simões 
Published: June 2019

Este artigo discorre sobre os blocos de viagem feitos por Lucio Costa durante sua permanência em Portugal no ano de 1952 e ressalta a importância do croqui como ferramenta de conhecimento da arquitetura e portanto de projeto. Para a sua visão sobre a arquitetura brasileira era fundamental conhecer Portugal. É o interesse em conhecer a arquitetura portuguesa no seu local de origem que iria motivar Lucio Costa a empreender duas viagens de estudos por Portugal. A primeira ocorreu no ano de 1948, da qual só restou um relatório e da segunda, 304 desenhos distribuídos em 5 bloquinhos e 2 folhas avulsas.
Same‐Day Discharge After Elective Percutaneous Coronary Interventions in Ontario, Canada
Authors: Madan Mina , Bagai Akshay , Overgaard Christopher B. , Fang Jiming , Koh Maria , Cantor Warren J. , Garg Pallav , Natarajan Madhu K. , So Derek Y. F. , Ko Dennis T. 
Published: June 2019

Background

To manage overcrowding and bed shortages in Canadian hospitals, same‐day discharge (
SDD
) after percutaneous coronary intervention (
PCI
) has emerged as a solution to improve resource utilization. However, limited information exists regarding current trends, hospital variation, and safety of
SDD PCI
in Canada.

Methods and Results

We evaluated outpatients undergoing elective
PCI
in Ontario, Canada, from October 2008 to March 2016.
SDD
was defined when patients were discharged on the day of
PCI
, and non‐
SDD
was defined as those patients who had 1 overnight stay. The primary outcome was 30‐day all‐cause death or hospitalization for acute coronary syndrome. Inverse probability of treatment weighting with propensity score was used to account for differences in baseline and clinical characteristics between
SDD
and non‐
SDD
groups. Among 35 972 patients who underwent elective
PCI
at 17
PCI
centers in Ontario, 10 801 patients (30%) had
SDD PCI
and 25 121 patients (70%) had non‐
SDD PCI
. Substantial hospital variation for
SDD PCI
was observed, ranging from 0% to 87% during the study period. In the propensity‐weighted cohort,
SDD
patients had no significant difference in 30‐day rates of death or hospitalization for acute coronary syndrome (1.3% versus 1.6%; hazard ratio: 0.84 [95% CI, 0.65–1.08];
P
=0.17) compared with non‐
SDD
patients.
SDD
and non‐
SDD
patients also had no significant difference in 30‐day rates of mortality or coronary revascularization.

Conclusions

In this large population‐based cohort of elective
PCI
patients, we demonstrated the safety of
SDD PCI
. Increased adoption of this strategy could lead to improved bed‐flow efficiency and substantial savings for the Canadian healthcare system without comprising outcomes.
Pierwiastki męskie i kobiece w filmie "Aleksandra" w reżyserii Aleksandra Sokurowa
Authors: Korycka Agnieszka Magdalena 
Published: June 2019

The masculine and feminine elements in Aleksandr Sokurov’s film AlexandraThe aim of this article is to present the fundamentals of the Great Mother archetype in Aleksandr Sokurov’s film Alexandra using the anthropological-morphological method of analysis. The effect of meeting between the protagonists, Alexandra and Denis, and their interweaving, is a new person – a perfect being where the masculine and feminine is brought to a perfect harmony. Pierwiastki męskie i kobiece w filmie Aleksandra w reżyserii Aleksandra SokurowaArtykuł jest poświęcony przedstawieniu rudymentów archetypu Wielkiej Matki w filmie Aleksandra w reżyserii Aleksandra Sokurowa za pomocą metody analizy antropologiczno-morfologicznej dzieła filmowego. Efektem spotkania bohaterów i ich „czynności tkackich” jest nowa osoba – istota idealna, w której równowaga pierwiastków męskich i kobiecych osiągnęła stan pełnej harmonii.
Paradoksy w Dźiwy Goswamina koncepcji duszy, drogi do doskonałości oraz wyzwolenia
Authors: Wasilewska Dagmara 
Published: June 2019

Paradoxes in Jīva Gosvāmi’s concept of the soul, path to perfection and liberationThis article is devoted to the role and significance of paradoxes in the philosophical thought and mysticism of the sixteenth-century Bengali Vaishnava theologian Jīva Gosvāmi. He situates his system within the Vedanta school, where the main category distinguishing its branches and deciding on their specific character is the relation between the Absolute, the phenomenal world and the human being. In Gosvāmi’s school, this relation involves identity and distinctness (bhedābheda) of those categories at the same time, referred to by the word acintya (“inaccessible to reason”), which further stresses this ontological paradox. Although doctrinally the most important, it is not the only paradox in Gosvami’s thought. Adopting this core metaphysical thesis engendered many other aporias, including those concerning the nature of the soul, the concept of bhakti (loving devotion to a deity) and the idea of liberation (mukti), which Goswami then attempts to solve in his most important philosophical treatise – Ṣaṭsandarbha. Paradoksy w Dźiwy Goswamina koncepcji duszy, drogi do doskonałości oraz wyzwoleniaPrzedmiotem artykułu jest rola i znaczenie paradoksów w myśli filozoficznej i mistyce teologa wisznuizmu bengalskiego – Dźiwy Goswamina (XVI w.). Sytuuje on swój system w obrębie szkoły wedanty, w której główną kategorią odróżniającą jej nurty i decydującą o ich specyfice jest relacja pomiędzy absolutem a światem zjawiskowym i człowiekiem. U Goswamina będzie to relacja jednoczesnej tożsamości i odrębności (bhedābheda) powyższych kategorii, dookreślona słowem acintya – „niedostępna rozumowi” – co dodatkowo uwydatnia ten ontologiczny paradoks. Chociaż doktrynalnie najistotniejszy, nie jest to jednak jedyny paradoks w myśli Goswamina. Poprzez przyjęcie tej nadrzędnej tezy metafizycznej powstało bowiem wiele innych aporii, między innymi dotyczących natury duszy, problemu wcielenia, a także koncepcji bhakti (nabożnego oddania dla bóstwa) oraz wyzwolenia (mukti), które następnie Goswamin stara się rozwiązać w swoim najważniejszym traktacie filozoficznym – Szatsandarbhsze.
Funkcja frazeologizmów w wybranych poznańskich powieściach kryminalnych
Authors: Nowak Marta 
Published: June 2019

The function of phraseology in selected crime novels set in the city of PoznańThis article presents several patterns concerning the function of phraseology in contemporary crime novels set in the city of Poznań. Standard Polish phraseologisms make the characters’ speech more colloquial, natural and expressive and are used to convey their emotions. The use of phraseological units typical of the region of Greater Poland adds local colour and makes the novels more realistic by closely relating them to the space where they are set. The use of phraseology also serves to characterise the protagonists. The study analyses four novels: Arcymistrz (Grandmaster) by Piotr Bojarski, Polichromia (Polychromy) by Joanna Jodełka, Upiory spacerują nad Wartą (Ghosts Walking on the Warta) by Ryszard Ćwirlej and Elektryczne perły (Bone Pearls) by Konrad T. Lewandowski. Funkcja frazeologizmów w wybranych poznańskich powieściach kryminalnychArtykuł prezentuje kilka prawidłowości widocznych w funkcjonowaniu frazeologizmów w wybranych współczesnych powieściach kryminalnych, których akcja rozgrywa się w Poznaniu. Frazeologizmyogólnopolskie przede wszystkim sprawiają, że wypowiedzi bohaterów przypominają mowę potoczną, są bardziej naturalne i ekspresywne. Bohaterowie w ten sposób przekazują swoje emocje. Frazeologizmy typowe dla Wielkopolski dodatkowo oddają koloryt lokalny i sprawiają, że powieści są oryginalniejsze, ściśle związane z przestrzenią, w której rozgrywa się akcja. Poza tym użycie frazeologizmów pozwala scharakteryzować bohaterów. Analizie poddano cztery powieści różnych autorów: Arcymistrza Piotra Bojarskiego, Polichromię Joanny Jodełki, Upiory spacerują nad Wartą Ryszarda Ćwirleja oraz Elektryczne perły Konrada T. Lewandowskiego.