bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolation, Screening and Identification of Biosurfactant Producing Strain Nocardiopsis dassonvillei var B2 From Oil Contaminated Soil
Authors: Panatula Nalini , Guntuku Girijasankar , Palla Mary Sulakshana , Muthyala Murali Krishna Kumar , Meka Madhavi , Jagadeeswara Reddy D. 
Published: October 2024

ABSTRACTPetroleum and other oil manufacturing industries contribute to environmental pollution by releasing hazardous hydrocarbons. Biosurfactants offer a sustainable solution for mitigating oil pollution through emulsification processes, safeguarding agricultural soils, aquatic ecosystems, and human health. This study focuses on isolating, screening, and identifying actinomycetes producing biosurfactant from oil‐polluted soil in the naval dockyard of Visakhapatnam. Biosurfactant production was successfully achieved utilizing Kim's medium, which was supplemented with olive oil serving as the carbon source. The evaluation involved preliminary identification tests, including oil displacement, Parafilm‐M, and lipase activity assays, using sodium lauryl sulfate as the standard reference. Surface tension and emulsification index measurements were conducted, and the chemical composition of glycolipids and phospholipids was elucidated using phenol‐sulfuric acid and phosphate assays. Glycolipids, specifically identified as rhamnolipids, were confirmed via cetyltrimethylammonium bromide (CTAB) testing and quantitatively analyzed using the orcinol method. The cell‐free broth exhibited antagonistic activity against Gram‐positive and negative bacilli.16S rRNA sequencing‐based phylogenetic analysis was carried out by the NCIM, Pune, with the gene sequence being deposited in GenBank. Further characterization of isolate B2 included scanning electron microscopy (SEM) analysis, as well as physiological and biochemical assays. This study highlights the ability of Nocardiopsis dassonvillei var. B2, isolated from oil‐polluted soil, to produce biosurfactants, specifically glycolipids identified as rhamnolipids. Our findings represent the first reported instance of biosurfactant production from isolate B2 originating from the naval dockyard in Visakhapatnam, Andhra Pradesh, India.
Gastrointestinal manifestations of Rett syndrome: An updated analysis using the Gastrointestinal Health Questionnaire
Authors: Ihekweazu Faith D. , Motil Kathleen J. 
Published: October 2024

AbstractObjectiveWe conducted a nationwide survey using a validated Gastrointestinal Health Questionnaire (GHQ) for Rett syndrome (RTT) to provide an updated and accurate baseline assessment of the prevalence of common gastrointestinal (GI) issues in RTT, based on parental reporting.MethodsParents and caregivers of females with RTT or normally developing, unaffected, age‐matched controls completed the GHQ survey. The prevalence of GI symptoms and personality and mood symptoms due to stomach or intestinal problems, as well as GI medication usage and surgical interventions, were assessed in females with RTT and unaffected controls. The relation between GI symptoms and medication usage, surgical status, age, and genetic mutation were analyzed.ResultsParents of 118 females with RTT and 27 unaffected females completed the GHQ. GI symptoms were common in females with RTT, including constipation (81%), gas and bloating (70%), issues with eating, chewing and swallowing (73%), and irritability because of stomach or intestinal problems (53%). Females with RTT commonly used proton pump inhibitors (52%) and laxatives (64%). Medication usage was associated with significantly higher GHQ symptom scores. Parents of individuals with RTT reported a significantly higher prevalence of GI symptoms affecting their daughters in all symptom categories compared with unaffected females.ConclusionsGI problems are common in RTT and pose a significant medical burden to caregivers. The GHQ is a useful tool to assess GI issues in individuals with RTT. Improved recognition of these issues may allow for improved treatment and enhanced quality of life for girls and women affected by RTT.
A cross‐sectional study on quality of life in adult indolent systemic mastocytosis and its association with cutaneous involvement
Authors: Isoletta Eugenio , De Silvestri Annalisa , Bonelli Alice , Di Stefano Michele , Bono Elisa , Ferrari Jacqueline , Elena Chiara , Brazzelli Valeria 
Published: October 2024

AbstractBackgroundSystemic mastocytosis (SM) is characterized by abnormal mast cell accumulation in various tissues, including the skin, and encompasses several clinical variants, ranging from less aggressive to more severe forms. ISM, the most common variant, often presents with cutaneous manifestations, causing significant impairment in QoL due to mediator‐release symptoms and stigma associated with typical cutaneous lesions.ObjectivesThe study aimed to assess QoL impairment in ISM patients and its correlation with demographic and clinical data.MethodsA cohort of 52 adult ISM patients was evaluated using the Dermatology Life Quality Index (DLQI) and the mastocytosis QoL questionnaire (MC‐QoL). Questionnaire scores were then analyzed in relation to the clinical and demographic characteristics of the patients.ResultsOver half of the patients experienced mild or higher levels of impairment in QoL, with female patients showing greater impairment than males. Patients with recent symptom onset reported higher MC‐QoL scores, possibly due to psychological factors and lack of disease knowledge. Cutaneous symptoms significantly impacted QoL, and the visibility of lesions affected DLQI scores more than MC‐QoL scores. A moderately strong correlation was observed between DLQI and MC‐QoL scores, particularly in the Skin and Social Life domains. The study highlights gender differences in QoL impairment, suggesting the need for further investigation into potential social or cultural factors.ConclusionsWhile the study provides valuable insights into QoL impairment in ISM patients, its monocentric nature and small sample size are notable limitations. Further research is warranted to better understand the impact of SM on patients' well‐being and to identify effective strategies for managing symptoms and improving overall QoL in this population.
Experimental Study on Enhancement in the Tribological Behaviour of Military Grade Lubricant Using Titanium Dioxide Nanoadditives for Aerospace Applications
Authors: Senthil Kumar M. , Elayaperumal A. , Mada Sankaraiah , Sathyanarayana H. 
Published: October 2024

ABSTRACTThe coefficient of friction of low carbon chromium alloy steel with military grade lubricant was high, resulting in increased heat generation and temperature rise of the lubricant in the aircraft power transmission units such as engine gearbox, accessory gearbox and so on. To address this, the current research proposes the addition of TiO2 nanoparticles to MIL grade lubricant as an additive to enhance the tribological performance. In this experimental study, TiO2 nanolubricant was prepared using various surfactants for better suspension of TiO2 nanoparticles, and properties were evaluated for both base lubricant and nanolubricant. The tribological experiments were conducted using a four ball tester, a shear stability tester and a reichert tester. In a four ball test, TiO2 nanolubricant resulted in a 27.3% reduction in wear scar diameter by the addition of TiO2 nanoparticles to the base lubricant. In a shear stability test, TiO2 nanolubricant showed 80% better shear stability than the base lubricant. In the reichert test, the coefficient of friction was reduced by 13% with the TiO2 nanolubricant. The experimental findings demonstrated that the TiO2 nanoparticles, as an additive to a military grade lubricant, have superior tribological properties for aerospace applications.
Emerging Molecular‐Genetic Families in Dystonia: Endosome‐Autophagosome‐Lysosome and Integrated Stress Response Pathways
Authors: Calakos Nicole , Zech Michael 
Published: October 2024

AbstractAdvances in genetic technologies and disease modeling have greatly accelerated the pace of introducing and validating molecular‐genetic contributors to disease. In dystonia, there is a growing convergence across multiple distinct forms of the disease onto core biological processes. Here, we discuss two of these, the endosome‐autophagosome‐lysosome pathway and the integrated stress response, to highlight recent advances in the field. Using these two pathomechanisms as examples, we further discuss the opportunities that molecular‐genetic grouping of dystonias present to transform dystonia care. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Massive Data HBase Storage Method for Electronic Archive Management
Authors: Su Huaquan , Li Junwei , Guo Li , Wang Wanshuo , Yang Yongjiao , Wen You , Li Kai , Mo Pingyan 
Published: October 2024

ABSTRACTThe acceleration of the digitalization process in enterprise and university education management has generated a massive amount of electronic archive data. In order to improve the intelligence, storage quality, and efficiency of electronic records management and achieve efficient storage and fast retrieval of data storage models, this study proposes a massive data storage model based on HBase and its retrieval optimization scheme design. In addition, HDFS is introduced to construct a two‐level storage structure and optimize values to improve the scalability and load balancing of HBase, and the retrieval efficiency of the HBase storage model is improved through SL‐TCR and BF filters. The results indicated that HDFS could automatically recover data after node, network partition, and NameNode failures. The write time of HBase was 56 s, which was 132 and 246 s less than Cassandra and CockroachDB. The query latency was reduced by 23% and 32%, and the query time was reduced by 9988.51 ms, demonstrating high reliability and efficiency. The delay of BF‐SL‐TCL was 1379.28 s after 1000 searches, which was 224.78 and 212.74 s less than SL‐TCL and Blockchain Retrieval Acceleration and reduced the delay under high search times. In summary, this storage model has obvious advantages in storing massive amounts of electronic archive data and has high security and retrieval efficiency, which provides important reference for the design of storage models for future electronic archive management. The storage model designed by the research institute has obvious advantages in storing massive electronic archive data, solving the problem of lack of scalability in electronic archive management when facing massive data, and has high security and retrieval efficiency. It has important reference for the design of storage models for future electronic archive management.
Towards using active learning methods for human‐seat interactions to generate realistic occupant motion
Authors: Fahse Niklas , Harant Monika , Obentheuer Marius , Linn Joachim , Fehr Jörg 
Published: October 2024

AbstractIn the context of developing new vehicle concepts, especially autonomous vehicles with novel seating arrangements and occupant activities, predicting occupant motion can be a tool for ensuring safety and comfort. In this study, a data‐driven surrogate contact model integrated into an optimal control framework to predict human occupant behavior during driving maneuvers is presented. High‐fidelity finite element simulations are utilized to generate a dataset of interaction forces and moments for various human body configurations and velocities. To automate the generation of training data, an active learning approach is introduced, which iteratively queries the high‐fidelity finite element simulation for an additional dataset. The feasibility and effectiveness of the proposed method are demonstrated through a case study of a head interaction with an automotive headrest, showing promising results in accurately replicating contact forces and moments while reducing manual effort.
Case report: Dichloroacetate‐induced methaemoglobinaemia in a G6PD‐deficient neonate
Authors: Tan Ze Lei , Ng Nicholas Beng Hui , Ong Jacqueline Soo May 
Published: October 2024

AbstractA 3‐week‐old neonate with glucose‐6‐phosphate dehydrogenase (G6PD) deficiency and primary lactic acidosis developed haemolytic jaundice and methaemoglobinaemia following treatment with dichloroacetate (DCA), a standard treatment for primary lactic acidosis. While this mechanism has been reported in the sheep model, it has not been described in humans. Our case reinforces the uncommon observation that a G6PD‐deficient individual experiencing oxidative stress may develop concurrent methaemoglobinaemia. In this case, methylene blue, the standard treatment for methaemoglobinaemia, may result in further oxidative stress. The judicious use of blood transfusion to correct the oxygen‐carrying capacity of our patient led to reversal of the methaemoglobinaemia.
Novel polystyrene‐based light diffusing materials: Introduction of magnesium hydroxide to enhance scattering range and thermal conductivity
Authors: Zhu Huihao , Wang Yu , Wan Zhou , Ma Yulu , Li Guo , Xie Linsheng 
Published: October 2024

AbstractIn high‐power lighting, large‐screen display, and other practical application scenarios, Light diffusing materials (LDMs) with favorable thermal conductivity are desired to assist in heat dissipation. In this paper, platy magnesium hydroxide (pMH) and mesoporous spherical magnesium hydroxide (sMH) were introduced as scattering particles for the first time to prepare polystyrene (PS)‐based LDMs. The limited refractive index mismatch allowed MH to be filled in large quantities with less sacrifice of light transmission performance. Owing to the complex surface morphology and large specific surface area, sMH possesses stronger scattering capability, and its combination addition with pMH could effectively increase scattering range. Meanwhile, an effective filler network was constructed with the combined use of pMH and sMH, and thus enhanced the thermal conductivity of the composites. Additionally, PS/pMH‐sMH composites exhibited higher thermal stability. This study expands the auxiliary thermal management capability of light diffusion materials and presents a new application possibility for MH as scattering particles.Highlights
A new application possibility for Magnesium hydroxide as scattering particles.
Light transmittance degradation of PS/MH at high filler loadings was mitigated by RI matching.
Complex surface morphology endowed sMH with strong scattering capability.
Optimal filling ratio of pMH to sMH was tested for better scattering performance.
Extended scattering range, improved TC and thermal stability was achieved.
The Oncology QCARD Initiative: Fostering efficient evaluation of initial real‐world data proposals
Authors: Rivera Donna R. , Eckert Joy C. , Rodriguez‐Watson Carla , Lerro Catherine C. , Bertagnolli Monica M. , Hubbard Rebecca A. , Kushi Lawrence H. , Lund Jennifer L. , Schrag Deborah , Wang Shirley V. , Wood William A. , Lee Jennifer J. , Okafor Cristeen , Ghauri Kanwal , Winckler Susan C. , Kluetz Paul G. 
Published: October 2024

AbstractPurposeThe oncology quality, characterization, and assessment of real‐world data (Oncology QCARD) Initiative was formed to develop a set of minimum study design and data elements needed to evaluate the fitness of the real‐world data (RWD) source(s) proposed in an initial study concept as part of early interaction with scientific reviewers.MethodsA multidisciplinary executive committee (EC) was established to guide the Oncology QCARD Initiative. The EC conducted a landscape review of published literature, guidances, and guidelines to evaluate relevant dimensions of data quality measurement. Guided by the review and informed by expert feedback, the Oncology QCARD Initial Protocol Characterization (IPC) provides a summary of minimum elements needed to adequately describe an initial clinical study concept that involves RWD and is intended to support decision‐making.ResultsFit‐for‐use data and fit‐for‐purpose design emerged as themes from the landscape analysis. Data that are fit‐for‐use are both relevant (sufficiently capturing exposure, outcomes, and covariates) and reliable (understanding data accrual and quality control and whether the data represent the underlying concepts they are intended to represent) to answer a specific research question. A fit‐for‐purpose design takes appropriate steps to ensure internal and external validity and allows for transparency in reporting. The QCARD‐IPC focuses on high‐level characteristics of RWD sources and study design domains including data temporality, population, medical product exposure, comparators, and covariates, endpoints, statistical analysis, and data quality assurance plans.ConclusionsEvaluation of studies including RWD requires understanding the data source, study design, and potential biases to preliminarily evaluate whether selected RWD are fit‐for‐use for the research question. The Oncology QCARD‐IPC provides a structured, transparent approach to facilitate early review and enhanced communication between study sponsors and scientific reviewers of initial study proposals including RWD.
High‐precision numerical simulation method for thermal–mechanical coupling in rubbers
Authors: Zhang Li , Li Zhi , Fu Qiang , Tang Nian , Pan Siwei , Lin Musong , Wang Baocheng , Bai Pengxiang , Qiao Dan , Zhang Bo , Huang Fei 
Published: October 2024

AbstractImproving the precision of numerical simulations in thermal–mechanical coupling for amorphous polymer materials is crucial for their effective utilization. To enhance the precision of rubber numerical simulations, this study proposed a method considering the temperature and strain rate to establish tensile testing conditions based on the principle of time–temperature equivalence. Additionally, to obtain more precise parameters for hyperelastic constitutive equations, stress relaxation experiments were conducted to determine a set of stress values under complete rubber stress relaxation, which were used to fit the hyperelastic components of the hyper‐viscoelastic algorithm. A finite element model of rubber rebound was established, and a hyperelastic model based on loss factor and a hyperelastic model based on Prony series (hyper‐viscoelastic) were used to calculate the temperature changes caused by rubber rebound coefficient and energy dissipation during the rebound process at 110, 120, and 130°C. We compared the calculation results of these two algorithms with experimental data to verify their accuracy. The research results show that the average error of the rebound coefficient of the hyperelastic algorithm at three temperatures is 3.63%, and the average error of the rebound coefficient of the hyper‐viscoelastic algorithm at these three temperatures is 0.93%. The comparison with the rebound test results shows that the hyper‐viscoelastic method is more accurate and better captures the viscoelastic hysteresis of rubber, but the model calculation time is longer. In addition, at the moment of rebound sample impact, the maximum temperature rise amplitude of the hyperelastic algorithm sample impact position is 2.60, 1.75, and 0.91°C, which are 110, 120, and 130°C, respectively; The maximum heating amplitudes of the hyper‐viscoelastic algorithm are 2.05, 1.35, and 0.61°C. The hyper‐viscoelastic algorithm is closer to the actual test results.Highlights
Applied the principle of time–temperature equivalence.
Determination of material parameters using the hyper‐viscoelastic algorithm.
Calculated the temperature change during the rubber rebound process.
Synthesis and characterization of novel electrospun nanofibers based on taro starch: influence of solvent and isolation agent on morphology and diameter
Authors: Sawitri Asti , Luthfianti Halida Rahmi , Hapidin Dian Ahmad , Edikresnha Dhewa , Palar Pramudita Satria , Surtiyeni Neni , Wibowo Arie , Khairurrijal Khairurrijal 
Published: October 2024

AbstractThe utilization of natural polymers in producing electrospun nanofibers has received significant attention due to their biocompatibility, sustainability and diverse range of applications. This research focuses on synthesizing electrospun nanofibers derived from taro starch isolated from tubers. The investigation utilized SEM to examine the structure and size of the electrospun nanofibers. Formic acid and dimethyl sulfoxide solvents were tested to determine the most efficient solvent system for synthesizing taro starch nanofibers. The results demonstrated that the taro starch nanofibers can be effectively synthesized when using formic acid as the primary solvent. The study also investigated the impact of altering the volumetric ratio of formic acid to water on nanofiber morphology and size, finding that a lower formic acid fraction produced smooth fibers while a higher fraction resulted in fused fibers. The electrospinnability was further evaluated by comparing the effects of different isolation agents—distilled water and sodium metabisulfite—during the isolation process. The isolation agent significantly affected the fiber diameter, with notable differences observed in the smoothness of taro starch nanofibers at starch solution concentrations of 13, 15 and 17 wt%. Overall, the results of the study showed that the formation of taro starch fibers was influenced by the type of solvent, the volume fraction of the solvent to water, and the starch isolation agent. Successful fabrication of nanofibers from taro starch and its optimization parameters can contribute to the development of environmentally friendly nanofiber materials and offer a variety of applications in biomedicine, food and environmental engineering, such as tissue engineering, wound dressing, drug delivery, functional food delivery and food packaging. © 2024 Society of Chemical Industry.
Radical Copolymerization of 2‐Thiocyanatoethyl Substituted Acrylate to Introduce Thiol‐Acrylate‐Based Dynamic Bonds as Degradable Linker
Authors: Ye Feiyang , Yue Chaowei , Li Yifan 
Published: October 2024

ABSTRACTWe employ the 1,4‐cyano group migration radical polymerization strategy to copolymerize acrylates with 2‐thiocyanate ethyl substituted acrylates. The radical copolymerization can be effectively controlled using reversible addition−fragmentation chain‐transfer (RAFT) polymerization. This approach can incorporate thiol‐acrylate‐based dynamic bonds within the polymer main chain. Utilizing these dynamic bonds, we degrade the polymers under mild basic conditions, achieved with the assistance of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) to facilitate the reversible thiol‐Michael addition. Notably, high degradation efficiency is observed. This study exemplifies the application of 2‐thiocyanate ethyl substituted acrylate in radical copolymerization to produce degradable polymers.