bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anxiety Buffer Disruption: Relationship Threat, Death Anxiety, and Coping Appraisals Among Low and High Posttraumatic Stress Symptom Samples
Authors: Vail Kenneth E. , Courtney Emily P. , Goncy Elizabeth A. , Cornelius Talea , Edmondson Donald 
Published: June 2019

Objective: Prior work suggests that people function effectively in the world, in part, by relying on sociocultural anxiety-buffer systems to protect against death anxiety. However, traumatic experiences may overwhelm and disrupt those systems, and this work tests whether posttraumatic stress symptoms reflect a vulnerability to death anxiety and risk of coping failure.Method: Following posttraumatic stress screening (n = 4129), individuals with low (n = 187) and high (n = 186) posttraumatic stress symptoms engaged in either an anxiety-buffer stressor task (contemplating relationship problems) or control task. Participants subsequently reported death anxiety and made coping appraisals.Results: Results supported four key hypotheses. Among individuals with low posttraumatic stress: (1) death anxiety was low under control conditions but moderately increased after contemplating relationship problems; and (2) perceived coping ability remained high in both conditions. However, among those with high posttraumatic stress: (3) death anxiety was exceptionally high in both the relationship problems prime and the control conditions—indicating anxiety buffer disruption; and (4) perceived coping ability was low in the control condition, and even lower after contemplating relationship problems.Conclusions: These findings support the hypotheses and make novel contributions, in that prior research on the existential implications of PTSD have not considered that anxiety buffer disruption may be associated with failure to cope with new challenges after traumatic experiences. Future research should determine whether therapies can improve the core dimensions of functional worldviews, a sense of meaning and self-esteem, and whether such improvements result in improvements to perceived coping abilities.
Cyfip1Haploinsufficiency Does Not Alter GABAAReceptor δ-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV+Interneurons and Granule Cells
Authors: Trent Simon , Hall Jeremy , Connelly William M. , Errington Adam C. 
Published: June 2019

AbstractCopy number variation (CNV) at chromosomal region 15q11.2 is linked to increased risk of neurodevelopmental disorders including autism and schizophrenia. A significant gene at this locus is cytoplasmic fragile X mental retardation protein (FMRP) interacting protein 1 (CYFIP1). CYFIP1 protein interacts with FMRP, whose monogenic absence causes fragile X syndrome (FXS).Fmrpknock-out has been shown to reduce tonic GABAergic inhibition by interacting with the δ-subunit of the GABAAreceptor (GABAAR). Usingin situhybridization (ISH), qPCR, Western blotting techniques, and patch clamp electrophysiology in brain slices from aCyfip1haploinsufficient mouse, we examined δ-subunit mediated tonic inhibition in the dentate gyrus (DG). In wild-type (WT) mice, DG granule cells (DGGCs) responded to the δ-subunit-selective agonist THIP with significantly increased tonic currents. In heterozygous mice, no significant difference was observed in THIP-evoked currents in DGGCs. Phasic GABAergic inhibition in DGGC was also unaltered with no difference in properties of spontaneous IPSCs (sIPSCs). Additionally, we demonstrate that DG granule cell layer (GCL) parvalbumin-positive interneurons (PV+-INs) have functional δ-subunit-mediated tonic GABAergic currents which, unlike DGGC, are also modulated by the α1-selective drug zolpidem. Similar to DGGC, both IPSCs and THIP-evoked currents in PV+-INs were not different betweenCyfip1heterozygous and WT mice. Supporting our electrophysiological data, we found no significant change in hippocampal δ-subunit mRNA expression or protein level and no change in α1/α4-subunit mRNA expression. Thus,Cyfip1haploinsufficiency, mimicking human 15q11.2 microdeletion syndrome, does not alter hippocampal phasic or tonic GABAergic inhibition, substantially differing from theFmrpknock-out mouse model.
Two-Level Evolutionary Approach to Persistent Surveillance for Multiple Underwater Vehicles with Energy Constraints
Authors: Bychkov Igor , Kenzin Maksim , Maksimkin Nikolai 
Published: June 2019

Currently, the coordinated use of autonomous underwater vehicles groups seems to be the most promising and ambitious technology to provide a solution to the whole range of oceanographic problems. Complex and large-scale underwater operations usually involve long stay activities of robotic groups under the limited vehicle’s battery capacity. In this context, available charging station within the operational area is required for long-term mission implementation. In order to ensure a high level of group performance capability, two following problems have to be handled simultaneously and accurately – to allocate all tasks between vehicles in the group and to determine the recharging order over the extended period of time. While doing this, it should be taken into account, that the real world underwater vehicle systems are partially self-contained and could be subjected to any malfunctions and unforeseen events.
The article is devoted to the suggested two-level dynamic mission planner based on the rendezvous point selection scheme. The idea is to divide a mission on a series of time-limited operating periods with the whole group rendezvous at the end of each period. The high-level planner’s objective here is to construct the recharging schedule for all vehicles in the group ensuring well-timed energy replenishment while preventing the simultaneous charging of a plenitude of robots. Based on this schedule, mission is decomposed to assign group rendezvous to each regrouping event (robot leaving the group for recharging or joining the group after recharging). This scheme of periodic rendezvous allows group to keep up its status regularly and to re-plan current strategy, if needed, almost on-the-fly. Low-level planner, in return, performs detailed group routing on the graph-like terrain for each operating period under vehicle’s technical restrictions and task’s spatiotemporal requirements. In this paper, we propose the evolutionary approach to decentralized implementation of both path planners using specialized heuristics, solution improvement techniques, and original chromosome-coding scheme. Both algorithm options for group mission planner are analyzed in the paper; the results of computational experiments are given.
Simulation of Motion Stability of Deformed Elongated Bodies Based on Variations of Angular Velocities in Roll
Authors: Romanova Irina 
Published: June 2019

The class of moving objects, which are bodies of revolution, which for some reason have undergone irreversible deformations of the hull, is considered.
The immediacy of the problem being studied has to do both with the need to study the dynamics of such objects and the insufficiency of the studies already conducted, which are mainly focused on the study of the effects of aeroelasticity or mass asymmetry and do not affect the dynamics of bodies with irreversible deformations.
The problem of the motion stability of the considered objects, including the process of interaction of the longitudinal and lateral movements of the deformed body, is formulated. Particular attention is paid to the movement of the curved body with rotation about the roll and the identification of the presence of critical roll velocities. It is noted that for the case of passive movement there are three possible reasons for this interaction: aerodynamic, kinematic, inertial.
A theoretical approach has been developed that takes into account the specific features of the geometry of deformed bodies. The approach made it possible in practical studies to determine the allowable deformation levels and its relationship with the motion parameters of deformed bodies.
The stability analysis was carried out based on the stability criteria of the system solutions describing the body movement according to the Routh – Hurwitz criterion. The body parameters , which have a varying degree of influence on the stability of movement, are determined. In a more general case, the curve of the stability boundary for a given angular velocity in roll will have a more complex form than a simple hyperbola.
The possibility of obtaining a direct solution to a nonlinear to the determining parameters equation is also shown. It will make it possible to obtain the dependences of the critical heel velocities and stability ranges on these parameters.
Mathematical modeling based on the developed techniques, carried out for direct and curved bodies, showed that the body curvature has a significant effect on the displacement of the lines of derivative pitch moments in the angle of attack and the moment of sliding in the angle of slip relative to the limits of stability. The range of angular velocities for the roll is determined, in which a loss of stability is observed for the curved body. The effect of variations in the angular velocity and the relative change in the derivative of the yaw moment coefficient in the slip angle on the value of the determining factor from the stability conditions for the direct and curved bodies is analyzed. It is shown how the curvature of the body leads to a shift of the saddle point. The effect of a change in the Mach number on the determining coefficient of characteristic equations is analyzed.
Results of Holter monitoring in patients with angina pectoris treated by combination of trimethazidine with fabomotisol in the area of former armed conflict
Authors: Shakhbieva Z. Yu. , Abdullaev A. A. , Islamova U. A. , Abdullaeva A. A. 
Published: June 2019

Aim. To assess the effectiveness of trimetazidine and fabomotisol adding to standard treatment in patients with stable angina in the area of former armed conflict in point of improving of Holter monitoring parameters.Material and methods. One hundred and twelve patients with stable angina of the II-III functional classes (FC) living in the area of former armed conflict were randomly divided into two groups. For 6 months 54 patients (control group) received standard treatment (isosorbide dinitrate 40 mg/day, metoprolole tartras 50-100 mg/day, acetylsalicylic acid 100 mg/day, simvastatin 40 mg/day). Fifty eight patients (study group) in addition to a standard treatment, took trimetazidine 70 mg/day and fabomotisol 30 mg/day. Initially and after 6 months they underwent Holter monitoring.Results. In patients of the control group the number of episodes of silent myocardial ischemia was statistically significantly reduced (p<0,05). The duration of episodes of silent and manifest myocardial ischemia, ST segment depression >1 mm, and the number of patients with supraventricular and ventricular extrasystoles decreased not statistically significant (p>0,05). The number of episodes of manifest myocardial ischemia did not change. In the study group, the number of silent ischemia episodes, the duration of silent and manifest myocardial ischemia significantly decreased. ST segment depression and the frequency of ventricular extrasystoles were also decreased (p<0,05). At the same time, the changes in number of supraventricular extrasystoles was not statistically significant (p>0,05). Conclusion. Using a combination of trimetazidine with fabomotisol in comparison with standard treatment in patients with angina reduces the frequency of angina episodes, the duration of myocardial ischemia, ST segment depression, the frequency of supraventricular and ventricular extrasystoles.
Prognostic value of the cardiac fraction of fatty acid binding protein in patients with non-ST elevation acute coronary syndrome with concomitant type 2 diabetes
Authors: Berns S. A. , Zakharova V. A. , Shmidt V. S. , Lynev V. S. , Zverev К. V. 
Published: June 2019

Aim. To study the association between a positive results of Heart-type fatty acid binding protein (h-FABP) test with the development of adverse outcomes during the year of observation in patients with non-ST elevation acute coronary syndrome (NSTE-ACS) depending on the type 2 diabetes mellitus (DM-2) presence.Material and methods. The study included 153 patients with NSTEACS hospitalized in the department of emergency cardiology in the period from March 2014 to January 2017. In addition to the standard examination, all patients underwent a qualitative analysis on the h-FABP in venous blood. Results. Kaplan–Meier estimator demonstrated a significant probability of a combined end point in patients with positive h-FABP, both with and without DM-2. H-FABP also acts as a marker for the development of adverse outcomes during the year after NSTE-ACS. Patients with adverse outcomes and type 2 diabetes mellitus had the highest frequency (100%) of positive test reactions.Conclusion. H-FABP positive test when admitted to hospital may be considered as a predictor of adverse long-term outcomes in patients with NSTE-ACS. That statistics is most significant for patients with DM-2.
Predictors of the development of non-cardiogenic syncopal conditions at a young age
Authors: Napalkov D. A. , Sokolova A. A. , Kondratyuk M. R. , Kudryavtseva A. A. , Krupenin P. M. , Savkov G. E. , Savkova O. D. , Yagofarova S. Yu. , Buchneva A. V. , Kwedhi J. M. 
Published: June 2019

Aim. Syncopal condition in young people are a relatively frequent and poorly understood medical problem. Non-cardiogenic syncope is not sufficiently studied because often they are not raise fears among doctors or patients, and at the same time their causes are associated with many complex medical and diagnostic aspects. The aim of the presented work is to identify the most significant risk factors in the development of non-cardiogenic syncopal conditions, identify triggers and assess the relationship between these factors, the lifestyle and development of syncope.Material and methods. The article presents the results of a descriptive research, including 1031 young people with a history of syncope episodes. The study took into account the presence of chronic diseases which could become a syncope trigger. External triggers (prolonged upright staying, stuffy room, and so on) were also determined.Results. In a multifactor survey of students living in Russia and abroad, the more frequent occurrence of non-cardiogenic syncopal episodes in young girls compared with young men was found. The effect of longterm upright and oxygen corporal were most likely risk factors for syncope.Conclusion. A significant correlation was found between the onset of reflex syncope and the presence of anemia and autonomic dysfunction syndrome. We proved the absence of a correlation between the level of daily load and the frequency of syncope conditions.
Development of a novel monoclonal antibody against chitinase-like protein YKL-39 applicable for immunohistochemistry
Authors: Gratchev A. N. , Samoilova D. V. , Kurochkin S. N. , Kovaleva O. V. 
Published: June 2019

Introduction. Mammalian chitinase-like proteins are produced in the areas of inflammation and in tumors. Some members of chitinase-like proteins family are studied as potential biomarkers of tumors (glioma, prostate and ovary). YKL-39 also known as chitinase-3-like 2 (CHI3L2) is a secreted protein produced by chondrocytes. Its high expression is also found in synoviocytes, lung heart and macrophages.The aim of this study was the development of highly specific monoclonal antibodies against human YKL-39. Materials and methods. Using recombinant full-length human YKL-39 as immunogen using hybridoma technology we have generated monoclonal antibody 1B2G4, that specifically binds YKL-39 in ELISA.Results and conclusion. Obtained antibody was successfully tested in Western blot, immunocytochemistry, immunofluorescence and immunohistochemistry on FFPE sections. It was shown that the antibody binds the full-length YKL-39 protein and does not interact with other chitinase-like proteins.
N-glycosidesindolo[2,3,-a]pyrrolo[3,4,-c]carbazole derivatives chemical structure influence on antitumor activity
Authors: Kiseleva M. P. , Pokrovsky V. S. , Borisova L. M. , Golubeva I. S. , Ektova L. V. 
Published: June 2019

Introduction . The report considers the prospect of rational approach to the new anticancer agents creation based on indolocarbazole derivatives.Objective . To conduct a comparative study of 12 domestic N-glycosides, indolo[2,3-a]pirrolo[2,3-a]carbazole derivatives in the course of “structure – activity” bond analysis.Materials and methods . The investigation of influence of 12 carbohydrate – containing indolocarbazoles, synthesized in N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia, performed on models of solid transplantable mouse tumors: lung Lewis epidermoid carcinoma and B16 melanoma. The antitumor effect was assessed by Lewis epidermoid carcinoma and B16 melanoma tumor growth inhibition (TGI %) criterion.Results . A variety of indolocarbazoles modifications allowed revealing the dependence of their antitumor properties on the structure of both, the aglycone and the glycoside residue. Imino-nitrogen interchange of atoms in upper heterocycle influences on indocarbazole derivatives antitumor activity change. During a comparative study of 12 N-glycosides indolocarbazole derivatives on lung Lewis epidermoid carcinoma and B16 melanoma models, 8 derivatives showed antitumor activity.Conclusion . The formulated concepts on the modification features in indolocarbazole derivatives structure can be used for more active compounds creation with greater action selectivity.
The influence of multiphytoadaptogen on leukocyte infiltration in mice hepatocarcinomas
Authors: Karpova R. V. , Bocharov E. V. , Bocharova O. A. , Kazeev I. V. , Kucheryanu V. G. , Soloviev Yu. N. 
Published: June 2019

The aim of this study was the morphological investigation of the CBA mice liver tissue at different stages of ontogenesis as well as during liquid form multifitoadaptogen therapeutic administration.Materials and methods . The study objects are the liver samples of CBA male mice (subline CBA / LacY). Experimental animals received a 10 % solution of multifitoadaptogen from 6 months of age until natural death. Tissue samples were fixed in neutral buffered formalin and embedded in paraffin. Sections from paraffin blocks were stained with hematoxylin and eosin. The structure of the liver tumours was determined as well as the quantitаtive degree of leukocyte infiltration in the tumour tissue.Results . The tumours morphologically structured as moderately differentiated trabecular hepatocarcinomas (at 8 months of age) and low differentiated trabecular-acinar hepatocarcinomas (aged 22 months) were revealed in CBA male mice. Higher lever of leukocyte infiltration in hepatocarcinomas of experimental animals was determined.Conclusion . Leukocyte infiltration may be important for antitumour immune reaction as well as for reduction of the tumour formation incidence in high-cancer mice.
Créditos
Authors: Guimarães Gustavo Cerqueira 
Published: June 2019

Créditos do v. 4, n. 1, jan.-abr., 2019. Faculdade de Letras da UFMGDiretora: Profª Graciela Inés Ravetti de GómezVice-Diretora: Profª Sueli Maria Coelho EditoresElcio Loureiro CornelsenGustavo Cerqueira Guimarães Editores de seçãoDossiê – FutebóisSilvana Goellner (UFRGS) Entrevista e Poética Gustavo Cerqueira Guimarães Pareceristas desta ediçãoAndré Mendes Capraro, UFPRCésar Castilho, UEMGCleber Dias, UFMGChristina Fornaciari, UFVEduardo de Gomes, UFRJLuiz Carlos Ribeiro, UFPRMarcelino da Silva, UFMGMarcel Vejmelka, Univ. de MainzRaphael Rajão, FGVThiago Costa, UFMGYvonne Hendrich, Univ. de Mainz Projeto gráficoPeDRa LeTRa Coordenação Editorial, Preparação de Originais, Diagramação e Editoração eletrônicaGustavo Cerqueira Guimarães Editoração eletrônica em Redes sociaisErilma DesireéGabriel Canuto da Gama Imagem da capa do portalPablo Lobato (Brasil)Um a zero #2 (2012) Imagem da capa deste númeroDaniel Kfouri (Brasil)Sem título, 201?.
"Sabe aquele gol que o Pelé não fez? Eu fiz!: a trajetória esportiva de Duda" (2018), de Silvana Goellner e Suellen Ramos
Authors: Costa Thiago Carlos 
Published: June 2019

Resenha sobre o livro Sabe aquele gol que o Pelé não fez? Eu fiz!: a trajetória de Duda, de autoria das pesquisadoras Silvana Vilodre Goellner e Suellen dos Santos Ramos.
La competencia científica en los libros de texto de Educación Primaria
Authors: Laya Iglesias Paula , Martinez Losada Cristina 
Published: June 2019

Este trabajo tiene como objetivo indagar en qué medida las actividades dirigidas al estudio del ser humano y la salud que proponen los libros de texto LOMCE de 6.º de Educación Primaria, correspondientes a tres editoriales de amplia implantación, promueven la adquisición de la competencia científica de los escolares. El análisis de las actividades (369 en total) se realiza teniendo en cuenta su tipología y el tipo de capacidades que dan ocasión de desarrollar. Respecto a ellas, además de los tres tipos definidos en PISA 2015 se consideran otras capacidades cognitivas presentes en las actividades. Los resultados muestran que la mayoría son cuestiones puntuales de tipo académico, muy centradas en el uso de capacidades ligadas al conocimiento científico en sí, mientras que las directamente asociadas a la competencia científica son poco consideradas. Lo indicado demanda un cambio en los planteamientos de los textos, pues constituyen un elemento clave en la innovación de la enseñanza.
L’entretien avec Jean-Paul Sartre. Le questionnaire implicite du discours sur la littérature des écrivains Verdier
Authors: Barraband Mathilde 
Published: June 2019

Nées en quelque sorte de la rencontre de Jean-Paul Sartre et de Benny Lévy à la fin des années 1970, les éditions Verdier ont aujourd’hui réussi à fédérer autour d’elles des écrivains importants de la littérature française contemporaine. Certains de ces écrivains (Pierre Bergounioux, François Bon, Didier Daeninckx, Pierre Michon, Natacha Michel et Olivier Rolin) et les éditeurs Verdier eux-mêmes ont en commun d’être passés de l’engagement gauchiste dans les années 1970 à l’engagement dans la littérature au début des années 1980. L’article pose alors ces questions : que reste-t-il, dans le discours sur la littérature de ces auteurs, des grands concepts, des grandes idées de Sartre? Quelles fonctions sociales assignent-ils à la littérature et pour qui affirment-ils écrire?AbstractArising from the meeting of Jean-Paul Sartre and Benny Levy in the late 70s, Éditions Verdier have now attracted important writers of contemporary French literature. These writers (Pierre Bergounioux, François Bon, Didier Daeninckx, Pierre Michon, Natacha Michel and Olivier Rolin) and Verdier as publishers have in common that they went from leftist commitment in the 70s to commitment in literature in the early 80s. The article raises the following questions: in the discourse on literature of these writers, what remains of Sartre's major concepts and main ideas? What social functions do they assign to literature? And for whom do they write?