bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parents’ and children’s comprehension and decision in a paediatric early phase oncology trial: a prospective study
Authors: Béranger Agathe , Bouazza Naïm , de Haut de Sigy Amélie , Foubert-Wenc Anne-Charlotte , Davous Dominique , Aerts Isabelle , Geoerger Birgit , Auvrignon Anne , Brethon Benoît , Leblond Pierre , Corradini Nadège , André Nicolas , Martinez Hélène , Dupont Jean-Claude K , Doz François , Chappuy Hélène 
Published: November 2018

Objective
To analyse parents’ and children’s understanding of consent information and assess their decision-making process in paediatric oncology.

Design
Prospective observational study.

Settings
Eleven French paediatric oncology units.

Patients
Parents and children who have been asked to give consent for participation in an early phase trial.

Interventions
Thirty-seven children and 119 parents were questioned using an audio-recorded semistructured interview.

Main outcome measures
The participants’ understanding of nine elements of the informed consent was assessed by comparing their answers with the informed consent leaflet. Their decision-making process was also evaluated.

Results
Most parents and children had an excellent understanding regarding their participation in a clinical trial (respectively 88.2% and 48.6%), the right to withdraw (76.5% and 43.2%) and the prospects of collective benefits (74.8% and 48.6%). By contrast, less than half of the parents and few of the children correctly understood the alternatives (respectively 47.5% and 27%), the risks related to participation (44.5% and 10.8%), the prospects of individual benefits (33.6% and 10.8%) and the purpose of the clinical trial (12.6% and 2.7%). Twenty-six (70.3%) children participated in the decision-making process. Most parents and children felt they had no choice but to participate in the trial to have access to a new anticancer treatment.

Conclusions
What might appear to be a poor understanding of the research protocol may actually correspond to the families’ interpretation of the situation as a coping mechanism. All children (except infants) should get age-tailored information in order for them to have a meaningful involvement in research.
Accuracy of real-time delivery room resuscitation documentation
Authors: Fishman Claire E , Weinberg Danielle D , Murray Ashley , Foglia Elizabeth E 
Published: November 2018

ObjectiveTo assess the accuracy of real-time delivery room resuscitation documentation.DesignRetrospective observational study.SettingLevel 3 academic neonatal intensive care unit.ParticipantsFifty infants with video recording of neonatal resuscitation.Main outcome measuresVital sign assessments and interventions performed during resuscitation. The accuracy of written documentation was compared with video gold standard.ResultsTiming of initial heart rate assessment agreed with video in 44/50 (88%) records; the documented heart rate was correct in 34/44 (77%) of these. Heart rate and oxygen saturation were documented at 5 min of life in 90% of resuscitations. Of these, 100% of heart rate and 93% of oxygen saturation values were correctly recorded. Written records accurately reflected the mode(s) of respiratory support for 89%–100%, procedures for 91%–100% and medications for 100% of events.ConclusionReal-time documentation correctly reflects interventions performed during delivery room resuscitation but is less accurate for early vital sign assessments.
School-related experience and performance with inflammatory bowel disease: results from a cross-sectional survey in 675 children and their parents
Authors: Freckmann Magdalena , Seipp Alexander , Laass Martin W , Koletzko Sibylle , Claßen Martin , Ballauff Antje , Peplies Jenny , Timmer Antje 
Published: November 2018

ObjectiveWe describe school performance and experience in children with inflammatory bowel disease (IBD) across Germany and Austria. Predictors of compromised performance and satisfaction were evaluated to identify subgroups of increased risk.DesignThis cross-sectional analysis was based on a postal survey in children aged 10–15 with Crohn’s disease, ulcerative colitis or unclassified IBD and their families. Multivariate regression analysis was used to assess influential factors on parental satisfaction with school, attending advanced secondary education (ASE), having good marks and having to repeat a class. Satisfaction was assessed based on the Child Healthcare–Satisfaction, Utilisation and Needs instrument (possible range 1.00–5.00).ResultsOf 1367 families contacted, 675 participated in the study (49.4%). Sixty-eight participants (10.2%) had repeated a year, 312 (46.2%) attended ASE. The median school satisfaction score was 2.67 (IQR 2.00–3.33). High socioeconomic status (SES) and region within Germany were predictive for ASE (OR high SES 8.2, 95% CI 4.7 to 14.2). SES, female sex and region of residence predicted good marks. Grade retention was associated with an active disease course (OR 2.7, 95% CI 1.4 to 5.3) and prolonged periods off school due to IBD (OR 3.9, 95% CI 1.8 to 8.6).ConclusionsA severe disease course impacted on the risk of grade retention, but not on type of school attended and school marks. Low satisfaction of parents of chronically ill children with the school situation underlines the need for a more interdisciplinary approach in health services and health services research in young people.
Formalisation and subordination: a contingency theory approach to optimising primary care teams
Authors: Contandriopoulos Damien , Perroux Mélanie , Duhoux Arnaud 
Published: November 2018

ObjectiveWhile there is consensus on the need to strengthen primary care capacities to improve healthcare systems’ performance and sustainability, there is only limited evidence on the best way to organise primary care teams. In this article, we use a conceptual framework derived from contingency theory to analyse the structures and process optimisation of multiprofessional primary care teams.DesignWe focus specifically on inter-relationships between three dimensions: team size, formalisation of care processes and nurse autonomy. Interview-based qualitative data for each of these three dimensions were converted into ordinal scores. Data came from eight pilot sites in Quebec (Canada).ResultsWe found a positive association between team size and formalisation (correlation score 0.55) and a negative covariation (correlation score −0.64) between care process formalisation and nurses’ autonomy/subordination. Despite the study being exploratory in nature, such relationships validate the idea that these dimensions should be analysed conjointly and are coherent with our suggestion that using a framework derived from a contingency approach makes sense.ConclusionsThe results provide insights about the structural design of nurse-intensive primary care teams. Non-physicians’ professional autonomy is likely to be higher in smaller teams. Likewise, a primary care team that aims to increase nurses’ and other non-physicians’ professional autonomy should be careful about the extent to which it formalises its processes.
Predictive value of CT angiography source image ASPECTS in patients with anterior circulation acute ischemic stroke after endovascular treatment: ultimate infarct size and clinical outcome
Authors: Park Jung-Soo , Lee Jong Myong , Kwak Hyo-Sung , Chung Gyoung Ho 
Published: November 2018

Background and purposeThe objective of this study was to investigate the predictive value of computed tomographic angiography (CTA) source image Alberta Stroke Program Early CT Score (ASPECTS) on clinical outcome and final infarction extent after endovascular treatment (EVT) in patients with acute ischemic stroke (AIS).MethodsAll eligible patients from January 2014 to March 2018 undergoing EVT due to anterior circulation AIS were retrospectively reviewed. The baseline ASPECTS on initial noncontrast CT (NCCT) and the CTA source image were compared with the follow-up MR diffusion-weighted imaging (DWI) ASPECTS. Receiver operating characteristic (ROC) curve analysis was used to assess the predictive value of CTA ASPECTS for prediction of final infarct extent and good clinical outcome.ResultsOur sample included a total of 122 eligible patients (64 males, mean age 70 years) with a median baseline National Institute of Health Stroke Scale (NIHSS) score of 12. Baseline ASPECTS on the CTA source image correlated with follow-up MR DWI ASPECTS better than NCCT ASPECTS (P<0.001). ROC curve analysis revealed baseline CTA ASPECTS (area under the curve [AUC] =0.74, 95% CI: 0.65 to 0.83, P<0.001) can better predict favorable functional outcome than NCCT ASPECTS (AUC=0.64, 95% CI: 0.54 to 0.74, P=0.008). Baseline NIHSS score <15, CTA ASPECTS≥8, and successful recanalization were independent predictors of good clinical outcomes.ConclusionThe ASPECTS on the CTA source image provides more information in the prediction of good clinical outcome and final infarction size than NCCT in patients with AIS treated with EVT.
Reduced plasma levels of small HDL particles transporting fibrinolytic proteins in pulmonary arterial hypertension
Authors: Harbaum Lars , Ghataorhe Pavandeep , Wharton John , Jiménez Beatriz , Howard Luke S G , Gibbs J Simon R , Nicholson Jeremy K , Rhodes Christopher J , Wilkins Martin R 
Published: November 2018

BackgroundAberrant lipoprotein metabolism has been implicated in experimental pulmonary hypertension, but the relevance to patients with pulmonary arterial hypertension (PAH) is inconclusive.ObjectiveTo investigate the relationship between circulating lipoprotein subclasses and survival in patients with PAH.MethodsUsing nuclear magnetic resonance spectroscopy, 105 discrete lipoproteins were measured in plasma samples from two cohorts of patients with idiopathic or heritable PAH. Data from 1124 plasma proteins were used to identify proteins linked to lipoprotein subclasses. The physical presence of proteins was confirmed in plasma lipoprotein subfractions separated by ultracentrifugation.ResultsPlasma levels of three lipoproteins from the small high-density lipoprotein (HDL) subclass, termed HDL-4, were inversely related to survival in both the discovery (n=127) and validation (n=77) cohorts, independent of exercise capacity, comorbidities, treatment, N-terminal probrain natriuretic peptide, C reactive protein and the principal lipoprotein classes. The small HDL subclass rich in apolipoprotein A-2 content (HDL-4-Apo A-2) exhibited the most significant association with survival. None of the other lipoprotein classes, including principal lipoprotein classes HDL and low-density lipoprotein cholesterol, were prognostic. Three out of nine proteins identified to associate with HDL-4-Apo A-2 are involved in the regulation of fibrinolysis, namely, the plasmin regulator, alpha-2-antiplasmin, and two major components of the kallikrein–kinin pathway (coagulation factor XI and prekallikrein), and their physical presence in the HDL-4 subfraction was confirmed.ConclusionReduced plasma levels of small HDL particles transporting fibrinolytic proteins are associated with poor outcomes in patients with idiopathic and heritable PAH.
Antibacterial properties of subphthalocyanine and subphthalocyanine-TiO2 nanoparticles on Staphylococcus aureus and Escherichia coli
Authors: Ozturk Ismail , Tunçel Ayça , Ince Mine , Ocakoglu Kasim , Hoşgör-Limoncu Mine , Yurt Fatma 
Published: November 2018

Nowadays the problem of antimicrobial resistance is the most important cause of morbidity and mortality in the treatment of infectious diseases worldwide. Treatment options for antimicrobial-resistant microorganisms are quite limited. Therefore, alternative treatment strategies are needed to control infectious diseases. Antimicrobial photodynamic therapy (aPDT) is one of the new treatment modalities proposed for a wide variety of infections. In the basic principle of aPDT, photosensitizers (PS) produce free radicals by irradiating them with harmless light at the appropriate wavelength, and this causes microorganism cell cytotoxicity. In this study, light emitting diodes (LED) (630–700 nm, 17.4 mW/cm[Formula: see text] were used on Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) at different light doses under the minimum inhibitory concentration (MIC) values of SubPc and SubPc-integrated TiO2 nanoparticles (SubPc-TiO[Formula: see text] concentration. Both compounds show good phototoxicity toward S. aureus when high light doses (16, 24[Formula: see text]J/cm[Formula: see text] were applied. In addition, SubPc-TiO2 were found to be more effective than SubPc in aPDT of S. aureus. In E. coli, the success of aPDT has been shown to be dependent on the increased light dose (20, 30[Formula: see text]J/cm[Formula: see text] for both compounds. As a result, the aPDT activity of SubPc-TiO2 is more effective than SubPc in increasing light doses.
Structural Changes in the Pacific–Japan Pattern in the Late 1990s
Authors: Xu Peiqiang , Wang Lin , Chen Wen , Feng Juan , Liu Yuyun 
Published: November 2018

AbstractThe Pacific–Japan (PJ) pattern, also known as the East Asia–Pacific pattern, is a teleconnection that significantly influences the East Asian summer climate on various time scales. Based on several reanalysis and observational datasets, this study suggests that the PJ pattern has experienced a distinct three-dimensional structural change in the late 1990s. Compared with those during 1979–98, the PJ pattern shifts eastward by approximately 20° during 1999–2015, and the intensity of its barotropic structure in the extratropics weakens significantly. As a result, its influences on the summer rainfall along the mei-yu band are weakened after the late 1990s. These observed changes can be attributed to three reasons. First, the location where the PJ pattern is excited shifts eastward. Second, the easterly shear of the background wind is very weak around the source region of the PJ pattern after the late 1990s, which prevents the convection-induced baroclinic mode from converting into barotropic mode and thereby from propagating into the extratropics. Third, the PJ pattern–induced rainfall anomalies are weak along the mei-yu band after the late 1990s. As a result, their feedbacks to the PJ pattern become weak and play a considerably reduced role in maintaining the structure of the PJ pattern in the midlatitudes. In contrast, the eddy energy conversion from the basic flow efficiently maintains the PJ pattern before and after the late 1990s and thereby contributes little to the observed change.
External accelerated partial breast irradiation for ductal carcinoma in situ: long-term follow-up from a phase 3 randomized trial
Authors: Becherini Carlotta , Meattini Icro , Livi Lorenzo , Garlatti Pietro , Desideri Isacco , Scotti Vieri , Orzalesi Lorenzo , Sanchez Luis Jose , Bernini Marco , Casella Donato , Nesi Silvia , Nori Jacopo , Bianchi Simonetta , Pallotta Stefania , Marrazzo Livia 
Published: November 2018

Introduction: For a long time, accelerated partial breast irradiation (APBI) effectiveness for ductal carcinoma in situ (DCIS) has been debated, due to conflicting published results. Recent encouraging data from phase 3 trials reopened new perspectives for this radiation approach. The aim of the present study was to analyze the long-term efficacy and safety results of the series of patients with DCIS enrolled in the APBI arm of the APBI-IMRT-Florence phase 3 trial (NCT02104895). Methods: Patients were treated in a phase 3 randomized trial comparing whole breast irradiation (50 Gy in 25 fractions to the whole breast, plus 10 Gy in 5 fractions to the tumor bed) to APBI (30 Gy in 5 nonconsecutive fractions) using the intensity-modulated radiotherapy technique. Results: Overall, 22 patients were treated in the APBI arm. Median age was 62 years (mean 59; range 42–75 years). At a median follow-up of 9.2 years (mean 8.8; range 3.8–12.1 years), no contralateral invasive/DCIS occurrence, distant metastasis, or breast cancer–related death were recorded. The 5- and 10-year local recurrence, distant metastasis–free survival, and breast cancer–specific survival were 100%. The 10-year overall survival rate was 90.9%. No late toxicity at 5 and 10 years was recorded. Conclusions: Waiting for pending studies and mature follow-up, we confirmed the efficacy and safety of APBI for low-risk DCIS.
Coping With Anterior Cruciate Ligament Injury From Childhood to Maturation: A Prospective Case Series of 44 Patients With Mean 8 Years’ Follow-up
Authors: Ekås Guri Ranum , Moksnes Håvard , Grindem Hege , Risberg May Arna , Engebretsen Lars 
Published: November 2018

Background: There is no consensus regarding the best treatment approach for skeletally immature children with anterior cruciate ligament (ACL) injuries. High-quality studies with long-term follow-up are lacking, and evidence to support decision making is limited. Purpose: To evaluate functional and patient-reported outcome, surgical history, and complications among young adults who sustained an ACL injury before the age of 13 years and were treated with active rehabilitation and the option of delayed ACL reconstruction if needed. Study Design: Case series; Level of evidence, 4. Methods: Forty-six children aged <13 years with a total intrasubstance ACL injury were included. None of these patients had additional injuries that warranted early surgery. At final follow-up at a mean 8 years after the time of injury, 44 patients remained in the study. The same test battery was conducted at baseline, 1 and 2 years, and final follow-up at approximately 18 years of age. The test battery included functional tests (hop tests and isokinetic muscle strength tests of quadriceps and hamstrings), patient-reported outcome measures (including the Knee injury and Osteoarthritis Outcome Score and the International Knee Documentation Committee Subjective Knee Form), and clinical examination. Medical records were reviewed to assess surgical history and complications. Results: At a mean 8 years of follow-up, 24 patients (55%) had undergone ACL reconstruction, and 16 (36%) had undergone meniscal surgery. Quadriceps muscle strength symmetry was >90% for 30 patients (68%). Mean leg symmetry indexes for hop and strength tests were consistently >90%, except for the single-hop test and hamstrings muscle strength for ACL-reconstructed knees. Mean ± SD International Knee Documentation Committee scores were 86.3 ± 13.7 for the ACL-reconstructed knees and 90.6 ± 11.8 for the nonreconstructed knees. At final follow-up, forty patients (91%) remained active in sports, but 29 (66%) restricted their activity level to nonpivoting sports. Conclusion: Active rehabilitation may have a role in treatment of children with ACL injury. Approximately 50% of children may cope well, even to adulthood, without a surgical intervention. The other half may develop instability that warrants ACL reconstruction, and one-third may require meniscal surgery.
Walkable Urban Design Attributes and Japanese Older Adults’ Body Mass Index: Mediation Effects of Physical Activity and Sedentary Behavior
Authors: Koohsari Mohammad Javad , Kaczynski Andrew T. , Nakaya Tomoki , Shibata Ai , Ishii Kaori , Yasunaga Akitomo , Stowe Ellen W. , Hanibuchi Tomoya , Oka Koichiro 
Published: November 2018

Purpose: The purposes of this study were to examine associations between objectively measured walkable urban design attributes with Japanese older adults’ body mass index (BMI) and to test whether objectively assessed physical activity and sedentary behavior mediated such associations. Design: Cross-sectional. Setting: Matsudo City, Chiba Prefecture, Japan. Participants: Participants were 297 older residents (aged 65-84 years) randomly selected from the registry of residential addresses. Measures: Walkable urban design attributes, including population density, availability of physical activity facilities, intersection density, and access to public transportation stations, were calculated using geographic information systems. Physical activity, sedentary behavior, and BMI were measured objectively. Analysis: The relationships of walkable urban design attributes, Walk Score®, and BMI were examined by multiple linear regression with adjustment for covariates in all models. Mediation effects of the physical activity and sedentary behavior variables in these relationships were tested using a product-of-coefficients test. Results: Higher population density and Walk Score® were associated with lower BMI. Light and moderate-to-vigorous physical activities partially mediated the relationships between these walkable urban design attributes and BMI. Conclusions: Developing active-friendly environmental policies to (re)design neighborhoods may not only promote active transport behaviors but also help in improving residents’ health status in non-Western contexts.
Hip Hip Hooray, ECT turns 80!
Authors: Clarke Patrick 
Published: November 2018

Objective: This paper reviews the history of electroconvulsive therapy (ECT) with an emphasis on the Australian context over the past 30 years. The review includes data collection, the contribution of the RANZCP, and changes in legislation. Conclusion: ECT remains the most effective treatment for severe depression. Since the 1950s efforts have been made to make it more effective, tolerable and acceptable. Over the same period, significant social and political forces have acted to have the practice of ECT restricted or banned. Psychiatrists, through the RANZCP and other bodies, have the responsibility to promote quality ECT practice, advocate for patients, carers, and clinicians, counter inaccurate negative portrayals, and lobby for balanced legislation for ECT and other neurostimulation.
Prevalence of self-reported computer vision syndrome symptoms and its associated factors among university students
Authors: Al Tawil Layan , Aldokhayel Sara , Zeitouni Leena , Qadoumi Tala , Hussein Siham , Ahamed Shaik Shaffi 
Published: November 2018

Purpose: To determine the prevalence of symptoms of computer vision syndrome and to identify its associated factors. The secondary objective was to assess knowledge and practices related to preventing computer vision syndrome symptoms. Methods: The data for this cross-sectional study were collected through a self-administered questionnaire distributed to 713 female undergraduates studying business and medicine in Saudi Arabia. The questionnaire included computer vision syndrome validated symptoms and factors associated with computer vision syndrome development. Results: The most common symptom due to prolonged computer use was neck or shoulder pain, reported by 82.2% of the subjects. Overall, 66.5% of the subjects suffered from headache and 51.5% from dry eyes, in mild, moderate, or severe form. Business students were 1.6 times as likely as medical students to suffer from computer vision syndrome (odds ratio = 1.65; 95% confidence interval: 1.22, 2.24). The use of electronic devices for more than 5 h (odds ratio = 1.52; 95% confidence interval: 1.07, 2.16) was also associated with experiencing computer vision syndrome symptoms. Regarding computer vision syndrome prevention, factors such as hours of use, screen distance, screen brightness, and room illumination showed statistically significant difference between the two groups (p < 0.0001). Conclusion: The prevalence of computer vision syndrome symptoms was significantly higher among business students, who reported lower awareness and poor practice measures of computer use recommendations. Relevant awareness campaigns focusing on the appropriate use of computers are highly recommended.