bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rational Design of Amyloid‐Like Fibrillary Structures for Tailoring Food Protein Techno‐Functionality and Their Potential Health Implications
Authors: Jansens Koen J.A. , Rombouts Ine , Grootaert Charlotte , Brijs Kristof , Van Camp John , Van der Meeren Paul , Rousseau Frederic , Schymkowitz Joost , Delcour Jan A. 
Published: November 2018

AbstractTo control and enhance protein functionality is a major challenge for food scientists. In this context, research on food protein fibril formation, especially amyloid fibril formation, holds much promise. We here first provide a concise overview of conditions, which affect amyloid formation in food proteins. Particular attention is directed towards amyloid core regions because these sequences promote ordered aggregation. Better understanding of this process will be key to tailor the fibril formation process. Especially seeding, that is, adding preformed protein fibrils to protein solutions to accelerate fibril formation holds promise to tailor aggregation and fibril techno‐functionality. Some studies have already indicated that food protein fibrillation indeed improves their techno‐functionality. However, much more research is necessary to establish whether protein fibrils are useful in complex food systems and whether and to what extent they resist food processing unit operations. In this review the effect of amyloid formation on gelation, interfacial properties, foaming, and emulsification is discussed. Despite their prevalent role as functional structures, amyloids also receive a lot of attention due to their association with protein deposition diseases, prompting us to thoroughly investigate the potential health impact of amyloid‐like aggregates in food. A literature review on the effect of the different stages of the human digestive process on amyloid toxicity leads us to conclude that food‐derived amyloid fibrils (even those with potential pathogenic properties) very likely have minimal impact on human health. Nevertheless, prior to wide‐spread application of the technology, it is highly advisable to further verify the lack of toxicity of food‐derived amyloid fibrils.
Development of Latent Fingermarks on Surfaces of Food‐A More Realistic Approach
Authors: Hong Sungwook , Park Jae‐Hee , Park Ju‐Hee , Oh Han‐byeol , Choi Eun‐Ju , Cho Il‐Han , Mok Yoon‐Jung 
Published: November 2018

AbstractLatent fingermark developing methods from food (mandarin, egg, banana, apple, potato, carrot, eggplant, onion, bell pepper, and tomato) surface has been studied by 10 methods, including powdering method, small particle reagent method, and cyanoacrylate fuming method. The foods were stored under two conditions (room temperature and refrigerator) before fingermark deposition and aged for 2, 24, 48, and 72 h before fingermark development. In most of the food surfaces used in this study, cyanoacrylate fuming with 80% relative humidity was superior to the powder or small particle reagent methods. The quality of the fingermarks varied depending on the storage conditions before the fingermark deposition (in the refrigerator or at ambient temperature) and the time elapsed since the fingermark deposition. However, the storage conditions before the fingermark deposition and the time elapsed since the fingermark deposition did not show any correlation with the quality of the fingermark.
The Effect of Pretreatment (Spray Drying) on the Yield and Selected Nutritional Components of Whole Camel Milk Powder
Authors: Habtegebriel Haileeyesus , Wawire Michael , Sila Daniel 
Published: November 2018

AbstractThe effect of spray drying on the composition of camel milk powder was evaluated. A full factorial experimental design was used to see the effects of inlet temperature (160 °C, 140 °C, and 120 °C), atomization pressure (800, 600, and 400 bar) and feed flow rate (5, 4, and 3 rev/s) on cyclone and vitamin C recoveries. Principal components analysis (PCA) was used to check classification of spray dried whole camel milk powders based on their processing conditions and multiple correspondence analysis (MCA) on the fatty acid profiles. The average proximate composition of the camel milk viz., fat, protein, lactose, and total solid were 3.0%, 3.21%, 3.01%, and 10.29% respectively. The powder yield (cyclone recovery) increased with increasing inlet temperature and decreasing feed flow rate. High outlet temperature and pressure decreased vitamin C recovery. As a result of PCA of the camel milk powders, they were classified into high heat treated and low heat treated milk powders while the MCA of the fatty acid profiles of camel milk powders were classified into high pressure and low pressure treated powders and it was concluded that higher atomization pressure caused increase in the content of fatty acids.Practical ApplicationDrying of camel milk (using spray drying) can extend its shelf life. The spray drying process must be optimized in order to retain the nutritional properties of the milk and the techno‐functional characteristics of the powder. Here, the effect of the spray drying conditions on the yield and selected nutritional components of the milk powder was studied using a bench top spray dryer. However, there is need to translate these findings to an industrial volume dryer. These findings will play a big role in future spray drying operations since retention of important nutritional components is an important part of food processing.
Effect of Different Storage Conditions on Analytical and Sensory Quality of Thermally Processed, Milk‐Based Germinated Foxtail Millet Porridge
Authors: Sharma Nitya , Alam Tanweer , Goyal S.K. , Fatma Sana , Pathania Sheetaal , Niranajan Keshavan 
Published: November 2018

AbstractFoxtail millet porridge was prepared using germinated grains and milk and was evaluated for its storage stability after thermal processing at ultra‐high temperatures (UHT) of 142 °C for 5 s and retort processing temperatures of 121.5 °C for 15 min. Various physical, chemical, and microbial changes of the porridge were studied for a storage period of 180 days at 25 ± 1 °C. Using consumer perception and survival analysis, the predicted shelf life of the UHT treated and retort processed foxtail millet porridge samples stored at 25 ± 1 °C was found to be 186 ± 9 days and 245 ± 15 days, respectively. Also, data from consumer liking, profiling, physical, chemical, and microbial parameters showed significant changes (P < 0.05) in the thermally treated packaged porridge samples over time. As the consumer overall acceptability decreased, the detection of positive attributes (thick and uniformly colored texture and appearance; grainy mouth texture; caramel taste and aroma) in the porridge decreased, while the detection of negative attributes (uneven, decolored, and curdled texture and appearance; sticky mouth texture; cooked, sour and off smell; cooked, sour and off taste) increased. The present study could establish a significant difference (P < 0.05) in the storage induced properties of UHT and retort processed porridge samples. The analytical evaluation of foxtail millet porridge found that UHT treated porridge was better in quality, but consumers preferred retort processed porridge.Practical ApplicationThe quality and sensory attributes, evaluated for UHT treated and retort processed porridge samples during the storage period of 180 days, were found to be contradictory. Based on the results of CATA sensory analysis, the shelf life of UHT treated and retort processed porridge samples was predicted to be more than 6 months. Therefore, both UHT treatment and retort processing can be effectively applied to prepare a ready to eat milk based porridge using germinated foxtail millet grains.
Development of a Sulfite‐Based Oxygen Scavenger and its Application in Kimchi Packaging to Prevent Oxygen‐mediated Deterioration of Kimchi Quality
Authors: Lee Jung‐Soo , Jeong Suyeon , Lee Hyun‐Gyu , Cho Chi Heung , Yoo SeungRan 
Published: November 2018

AbstractA sulfite‐based oxygen scavenger (SOS) was developed with sodium metabisulfite and applied to kimchi packaging in an attempt to prevent oxygen‐mediated kimchi quality degradation. The results of the oxygen‐scavenging capacity test showed that the SOS had a competitive oxygen‐scavenging performance in comparison with commercial oxygen scavengers. The kimchi was packaged with and without the SOS and stored over 12 weeks at 0 and 10 °C for an SOS application test. The kimchi treated with the SOS showed a significantly lower (P < 0.05) headspace oxygen and carbon dioxide concentration and pressure inside the packages than the control. The pH and titratable acidity values indicated that the SOS did not retard the kimchi fermentation process. The Hunter L, a, and b values in the kimchi packaged with the SOS were significantly higher (P < 0.05) than those in the control. After 12 weeks of storage, the total aerobic bacteria counts were reduced by 1.32 and 2.97 log CFU/g, lactic acid bacteria counts were reduced by 2.22 and 4.42 log CFU/g, and total yeasts and molds counts were reduced by 1.76 and 3.04 log CFU/g at 0 and 10 °C, respectively, by the SOS compared to those in the control. These results demonstrated that the developed SOS inhibited oxygen‐mediated deterioration of the kimchi, but did not affect the kimchi fermentation. Therefore, our SOS can be used as an active food‐packaging technology for kimchi quality preservation.Practical ApplicationA newly designed sulfite‐based oxygen scavenger was applied in kimchi packaging, and it showed remarkable preventive effects on the kimchi quality deterioration caused by oxygen. Accordingly, it can be used as an active food‐packaging technology to maintain kimchi quality during the storage period. Moreover, it can also be effectively utilized in the packaging of other high‐moisture foods such as meat, fish, fruits, vegetables, and dairy products.
Proanthocyanidins with a Low Degree of Polymerization are Good Inhibitors of Digestive Enzymes Because of their Ability to form Specific Interactions: A Hypothesis
Authors: Vazquez‐Flores Alma A. , Martinez‐Gonzalez Alejandra I. , Alvarez‐Parrilla Emilio , Díaz‐Sánchez Ángel G. , de la Rosa Laura A. , González‐Aguilar Gustavo A. , Aguilar Cristóbal N. 
Published: November 2018

AbstractInhibition of target digestive enzymes is an accepted strategy to prevent diseases such as obesity and diabetes. Proanthocyanidins (PACs) are known for their ability to bind, inhibit, and precipitate enzymes, which makes them potential bioDrugs with an impact on the digestive process. PAC degree of polymerization (DP) is one of the structural features responsible for their differential inhibitory potency but the explanation for this phenomenon is still unclear. Pecan nut (Carya illinoinensis L.) kernels and nutshells are rich in oligomeric and polymeric PACs. We have used thiolysis and HPLC analyses to propose four theoretical model structures of PACs representative of four semipurified fractions obtained from pecan kernel and shell, which showed different inhibitory activity against intestinal lipases, amylases, and proteases. The noncovalent interactions between PACs and digestive enzymes were predicted by in silico methods through computational software. These observations are discussed in view of current literature on the biological effects of PACs with different DPs and allowed us to propose the hypothesis that “small oligomeric PACs could be digestive enzyme inhibitors due to their capacity to enter and bind the enzymes’ specific cavities better than polymers and oligomers of medium and high molecular weight.”
Capn4 promotes esophageal squamous cell carcinoma metastasis by regulating ZEB1 through the Wnt/β‐catenin signaling pathway
Authors: Zhao Yun‐Long , Li Jing‐Bo , Li Ying‐Jie , Li Shao‐Jun , Zhou Shao‐Hua , Xia Hui 
Published: November 2018

BackgroundCapn4 and ZEB1 play important roles in the metastasis of several types of cancer. However, the roles and relationship of Capn4 and ZEB1 in esophageal squamous cell carcinoma (ESCC) remain unclear.MethodsESCC tumor tissues and corresponding normal esophageal epithelial tissues were obtained from 86 patients undergoing resection surgery at the Department of General Surgery, First Affiliated Hospital of Chinese PLA General Hospital from 2012 to 2017. Cell migration and invasion were examined via quantitative real‐time PCR and Western blot assay.ResultsOur results indicate that both Capn4 and ZEB1 are significantly upregulated in ESCC tissues compared to corresponding adjacent tissues, and a positive correlation between expression and associated malignant characteristics was found. Silencing of Capn4 expression markedly inhibited ESCC invasion and metastasis in vitro and in vivo, and was accompanied by decreased ZEB1 expression. Furthermore, the anti‐metastasis role of Capn4 silencing was reversed by ZEB1 overexpression, whereas knockdown of ZEB1 decreased ESCC metastasis driven by the upregulation of Capn4. Mechanistically, Capn4 regulated ZEB1 expression via activation of the Wnt/β‐catenin signaling pathway in ESCC cells.ConclusionOverall, our results show that enhanced Capn4 expression activates the Wnt/β‐catenin signaling pathway, resulting in increased ZEB1 expression and the promotion of ESCC cell metastasis.
Internal Information Quality and the Sensitivity of Investment to Market Prices and Accounting Profits
Authors: Heitzman Shane , Huang Mengjie 
Published: November 2018

ABSTRACTWe ask whether the quality of internal information matters for investment decisions. We predict that investment is more sensitive to internal profit signals and less sensitive to external price signals when managers have higher‐quality internal information. Consistent with recent theoretical and empirical research, we proxy for internal information quality using observable information properties. We find that the sensitivity of investment to profitability is increasing, while the sensitivity of investment to market‐to‐book is decreasing in internal information quality. Our focus on internal information and decision making offers new and unique insights on the importance of information quality and complements the growing literature on the role of external reporting quality in reducing financing frictions.
Evidence of Neolithic settlement in the foothills of the Western al‐Hajar Mountains
Authors: Bretzke Knut , Parton Ash , Lindauer Susanne , Kennet Derek 
Published: November 2018

AbstractSystematic prospection and excavations in the Rustaq region of northern Oman, approximately 45 km from the coast in the foothills of the Western Hajar Mountains, have revealed an unexpectedly dense record of Neolithic sites. Besides surface scatters of lithic artefacts, excavation at the site of Hayy al‐Sarh recovered two stratified archaeological horizons (AHs). The upper horizon, AH I, contained pierced marine shells that provided an age of the archaeological material of about 6800 to 7500 years cal BP. Typologically the AH I lithic assemblage compares to the Suwayh facies defined at the coast 300 km to the east. Whether the marine shells and cultural affinities point towards exchange with coastal communities or possibly seasonal movement remains an open question at this state of research, but this new evidence for inland Neolithic settlement near Rustaq provides important new data that will help improve our understanding of spatial patterns of Neolithic demographic variability.
Three‐Dimensional Numerical Simulations of Aspiration Process: Evaluation of Two Penumbra Aspiration Catheters Performance
Authors: Chitsaz Alireza , Nejat Amir , Nouri Reza 
Published: November 2018

AbstractAcute ischemic stroke (AIS) is the leading cause of mortality and disability worldwide. AIS occur while cerebral arteries become blocked by embolism or thrombosis. Aspiration thrombectomy is a promising interventional device to extract massive clots from occluded cerebral arteries. The aim of this article is to develop a computer‐aided method to clarify the performance of aspiration catheter and identify the risks of aspiration for each specific AIS patient. In order to simulate the aspiration process, a three‐dimensional fluid‐structure interaction (FSI) method was developed. The blood clot was modeled as a porous media which composed of viscoelastic fibrin networks. The finite element method (FEM) was implemented to compute the blood flow dynamics in the simplified cerebral vessel. The introduced clot model was validated by comparing the numerical results with experimental data. Furthermore, the analytical solution of the flow through the partially porous pipe was considered to validate FEM. In this research, the performance of two model of the Penumbra aspiration catheter—4MAX and 5MAX—were were compared at three distinct suction pressures. The aspiration ratio of the clot, aspiration time, amount of free fragments, wall shear stress (WSS), and extracted volume of the blood were calculated to evaluate catheters performance. At suction pressure −50 kPa, the aspiration ratio of 5MAX catheter reached 86.58% within 1.36 s. However, in 4MAX case, aspiration ratio of 76.41% was achieved within 1.39. Also, 5MAX catheter created 6.11% fewer free fragments in comparison to 4MAX. Hence, the possibility of distal embolization of 4MAX model was greater. However, the risk of vessel wall rupture was higher in 5MAX by considering mean WSS.
A Bayesian Hidden Markov Model for Detecting Differentially Methylated Regions
Authors: Ji Tieming 
Published: November 2018

Abstract
Alterations in DNA methylation have been linked to the development and progression of many diseases. The bisulfite sequencing technique presents methylation profiles at base resolution. Count data on methylated and unmethylated reads provide information on the methylation level at each CpG site. As more bisulfite sequencing data become available, these data are increasingly needed to infer methylation aberrations in diseases. Automated and powerful algorithms also need to be developed to accurately identify differentially methylated regions between treatment groups. This study adopts a Bayesian approach using the hidden Markov model to account for inherent dependence in read count data. Given the expense of sequencing experiments, few replicates are available for each treatment group. A Bayesian approach that borrows information across an entire chromosome improves the reliability of statistical inferences. The proposed hidden Markov model considers location dependence among genomic loci by incorporating correlation structures as a function of genomic distance. An iterative algorithm based on expectation-maximization is designed for parameter estimation. Methylation states are inferred by identifying the optimal sequence of latent states from observations. Real datasets and simulation studies that mimic the real datasets are used to illustrate the reliability and success of the proposed method.
Depression diagnoses, but not individual differences in depression symptoms, are associated with reduced autobiographical memory specificity
Authors: Farina Francesca R. , Barry Tom J. , van Damme Ilse , van Hie Thijs , Raes Filip 
Published: November 2018

ObjectivesDifficulties recalling specific events from one's autobiographical past have been associated with a range of emotional disorders. We present the first examination of whether diagnoses of depression or individual differences in depression severity explain the most variance in autobiographical memory specificity. We also examine the contribution of other key cognitive factors associated with reduced memory specificity – rumination and verbal fluency – to these effects.MethodsParticipants with (n = 21) and without (n = 25) major depressive disorder completed self‐report measures of depression severity (Beck Depression Inventory version II; BDI‐II) and ruminative tendency (Ruminative Response Scale), a measure of verbal fluency, and the Autobiographical Memory Test (AMT) to assess memory specificity.ResultsPeople diagnosed with depression recalled significantly fewer specific memories in the AMT relative to healthy controls. In a linear regression, diagnostic status explained a significant amount of unique variance in specificity whereas BDI‐II scores did not. Diagnostic group differences in verbal fluency also explained a significant amount of variance in specificity.ConclusionsOur findings extend our understanding of the mechanisms involved in reduced memory specificity but future research must explore the causal contribution of weak executive functioning to reduced memory specificity.Practitioners points

Diagnoses of depression were associated with problems recalling specific events from one's past.

Problems with memory specificity amongst depressed people were associated with executive functioning difficulties.

Problems with specificity were not associated with individual differences in depression severity or ruminative tendencies.
Impact of mobile‐based mentoring, socio‐economic background and religion on girls’ attitude and belief towards antisocial behaviour (ASB)
Authors: Abimbade Oluwadara , Adedoja Gloria , Fakayode Bukola , Bello Lukuman 
Published: November 2018

AbstractThis study examined the impact of mobile‐based mentoring, socio‐economic background and religion on girl’s attitude and belief towards ASB in Ibadan Oyo State Nigeria. The study adopted a mixed method research design. The participants in the study comprised forty (40) students purposively selected from Ibadan, Oyo State, Nigeria. The platform (www.gcmentoringinitiative.org) was adopted for mobile‐based mentoring. One research question was raised and three null hypotheses were tested in the study at .05 level of significance. Data were analysed using content analysis for Focus Group Discussion, Analysis of Covariance and Estimated Marginal Means. The results reveal a significant main effect of socio‐economic background on girl’s attitude towards ASB. Also, there was no significant impact of mobile‐based mentoring on girl’s attitude towards ASB. Based on the findings, using mobiles in mentoring girls could significantly reinforce or change their belief in engaging in antisocial activities. Also, the socio‐economic background plays a significant role in determining the attitude and belief of girls in engaging in antisocial activities. Girls’ religion has little or no effect on their belief and attitude towards antisocial behaviours (ASB). Girls from low‐income family are susceptible to engage in ASB, while those from wealthy homes are less likely to engage in ASB.
Downregulation of long non‐coding RNA Opa interacting protein 5‐antisense RNA 1 inhibits breast cancer progression by targeting sex‐determining region Y‐box 2 by microRNA‐129‐5p upregulation
Authors: Zeng Huijuan , Wang Jingjie , Chen Tao , Zhang Kai , Chen Jing , Wang Lulu , Li Hanjun , Tuluhong Dilihumaer , Li Jieshou , Wang Shaohua 
Published: November 2018

Several studies have shown an important role for long non‐coding RNA (lncRNA) in breast cancer progression. The present study investigated the role of lncRNA Opa interacting protein 5‐antisense RNA 1 (OIP5‐AS1) in the progression of breast cancer. OIP5‐AS1 was significantly upregulated in breast cancer tissues and in breast cancer cell lines, and OIP5‐AS1 downregulation inhibited the malignant behavior of breast cancer in vitro and in vivo. For in‐depth exploration of the mechanism of OIP5‐AS1 in breast cancer, we found that expression of microRNA‐129‐5p(miR‐129‐5p), which was found to bind sites in the sequence of OIP5‐AS1, in breast cancer tissues was negatively correlated with OIP5‐AS1. Also, luciferase assays indicated that OIP5‐AS1 acted as a miR‐129‐5p sponge, resulting in upregulated expression of the sex‐determining region Y‐box 2 (SOX2) transcription factor. Our study showed that OIP5‐AS1 plays a critical role in promoting breast cancer progression and that OIP5‐AS1 downregulation targets SOX2 by miR‐129‐5p upregulation.