bluuebunny/crossref_metadata_2025_split huggingface dataset:
Findings from the Section on Bioinformatics and Translational Informatics
Authors: Lecroq T. , Dauchel H. ,   Section Editors for the IMIA Yearbook Section on Bioinformatics and Translational Informatics
Published: March 2018

Summary
Objectives
: To summarize excellent current research and propose a selection of best papers published in 2015 in the field of Bioinformatics and Translational Informatics with application in the health domain and clinical care.

Method
: We provide a synopsis of the articles selected for the IMIA Yearbook 2016, from which we attempt to derive a synthetic overview of current and future activities in the field.

As last year, a first step of selection was performed by querying MEDLINE with a list of MeSH descriptors completed by a list of terms adapted to the section. Each section editor has evaluated separately the set of 1,566 articles and the evaluation results were merged for retaining 14 articles for peer-review.

Results
: The selection and evaluation process of this Yearbook's section on Bioinformatics and Translational Informatics yielded four excellent articles focusing this year on data management of large-scale datasets and genomic medicine that are mainly new method-based papers. Three articles explore the high potential of the re-analysis of previously collected data, here from The Cancer Genome Atlas project (TCGA) and one article presents an original analysis of genomic data from sub-Saharan Africa populations.

Conclusions
: The current research activities in Bioinformatics and Translational Informatics with application in the health domain continues to explore new algorithms and statistical models to manage and interpret large-scale genomic datasets. From population wide genome sequencing for cataloging genomic variants to the comprehension of functional impact on pathways and molecular interactions regarding a given pathology, making sense of large genomic data requires a necessary effort to address the issue of clinical translation for precise diagnostic and personalized medicine.
Update Breast Cancer 2018 (Part 2) – Advanced Breast Cancer, Quality of Life and Prevention
Authors: Schneeweiss Andreas , Lux Michael , Janni Wolfgang , Hartkopf Andreas , Nabieva Naiba , Taran Florin-Andrei , Overkamp Friedrich , Kolberg Hans-Christian , Hadji Peyman , Tesch Hans , Wöckel Achim , Ettl Johannes , Lüftner Diana , Wallwiener Markus , Müller Volkmar , Beckmann Matthias , Belleville Erik , Wallwiener Diethelm , Brucker Sara , Schütz Florian , Fasching Peter , Fehm Tanja 
Published: March 2018

AbstractThe treatment of metastatic breast cancer has become more complicated due to increasing numbers of new therapies which need to be tested. Therapies are now being developed to treat special clinical or molecular subgroups. Even though intrinsic molecular subtypes play a major role, more and more new therapies for subgroups and histological subtypes are being developed, such as the use of PARP inhibitors to treat patients with BRCA mutations (breast and ovarian cancer). Supportive therapies are also evolving, allowing problems such as alopecia or nausea and vomiting to be treated more effectively. Treatment-related side effects have a direct impact on the prognosis of patients with metastatic breast cancer, and supportive therapy can improve compliance. Digital tools could be useful to establish better patient management systems. This overview provides an insight into recent trials and how the findings could affect routine treatment. Current aspects of breast cancer prevention are also presented.
A comparative study of the Belt and Road Initiative and the Marshall plan
Authors: Shen Simon , Chan Wilson 
Published: March 2018

AbstractSince the introduction of the Belt and Road Initiative (BRI) in 2013, both the mainstream media and professional analysts began to name the Initiative “China’s Marshall Plan”. While the rhetoric may simply be an eye-catching term constructed in journalist and consultancy circles, this paper examines the background and purposes behind these two grand projects in order to shed light on the similarities and the differences of their effects on the world order. By comparing the projects under five different aspects—boosting exports, exporting currency, countering a rival, fostering strategic divisions, and siphoning away diplomatic support—this paper argues that while the two projects may have similarities and aim to respond to the malfunctioning world order through macro political-economic investments and developmental aid, their outcomes (given the relative differences of the global position of rivalries—USSR in Marshall Plan; US in BRI) and the changing economic structures, could be very different. As a result, this paper concludes that it may be too early to suggest that the BRI could bring similar outcomes as the Marshall Plan, especially in competing for the global leadership in the 21st century.
Curriculum making as professionalism‐in‐context: the cases of two elementary school teachers amidst curriculum change in Cyprus
Authors: Kontovourki Stavroula , Philippou Stavroula , Theodorou Eleni 
Published: March 2018

ABSTRACTIn this paper, two case studies of elementary school teachers in the Republic of Cyprus are constructed to discuss how curriculum making relates to teacher biographies and sense of professionalism, as those are shaped at the intersection of their professional history and projections for the future, informed by and informing their constitution as professionals in local institutional and broader social contexts. Drawing on the ecological model of teacher agency, the two cases are utilised to examine how teachers’ narrated professional experiences in past and current schools were at interplay with their general sense of professional role and purpose as teachers. This complex interplay is simultaneously connected to the ways they perceived and constituted their pupils as well as to the ways they themselves were constituted by others as professionals. The examination of the two cases foregrounds the notions of teacher agency and of curriculum making as contingent, negotiated and negotiable, and opens up the space to consider the politics of both as those are permeated by micro‐processes of subjection and subjectivation.
The efficacy of downhill running as a method to enhance running economy in trained distance runners
Authors: Shaw Andrew J. , Ingham Stephen A. , Folland Jonathan P. 
Published: March 2018

AbstractRunning downhill, in comparison to running on the flat, appears to involve an exaggerated stretch‐shortening cycle (SSC) due to greater impact loads and higher vertical velocity on landing, whilst also incurring a lower metabolic cost. Therefore, downhill running could facilitate higher volumes of training at higher speeds whilst performing an exaggerated SSC, potentially inducing favourable adaptations in running mechanics and running economy (RE). This investigation assessed the efficacy of a supplementary 8‐week programme of downhill running as a means of enhancing RE in well‐trained distance runners. Nineteen athletes completed supplementary downhill (−5% gradient; n = 10) or flat (n = 9) run training twice a week for 8 weeks within their habitual training. Participants trained at a standardised intensity based on the velocity of lactate turnpoint (vLTP), with training volume increased incrementally between weeks. Changes in energy cost of running (EC) and vLTP were assessed on both flat and downhill gradients, in addition to maximal oxygen uptake (⩒O2max). No changes in EC were observed during flat running following downhill (1.22 ± 0.09 vs 1.20 ± 0.07 Kcal kg−1 km−1, P = .41) or flat run training (1.21 ± 0.13 vs 1.19 ± 0.12 Kcal kg−1 km−1). Moreover, no changes in EC during downhill running were observed in either condition (P > .23). vLTP increased following both downhill (16.5 ± 0.7 vs 16.9 ± 0.6 km h−1
,
P = .05) and flat run training (16.9 ± 0.7 vs 17.2 ± 1.0 km h−1, P = .05), though no differences in responses were observed between groups (P = .53). Therefore, a short programme of supplementary downhill run training does not appear to enhance RE in already well‐trained individuals.
Bioactive compounds from palm fatty acid distillate and crude palm oil
Authors: Estiasih T , Ahmadi K 
Published: March 2018

Abstract
Crude palm oil (CPO) and palm fatty acid distillate (PFAD) are rich sources of bioactive compounds. PFAD is a by-product of palm oil refinery that produce palm frying oil. Physical refining of palm oil by deodorization produces palm fatty acid distillate. CPO and PFAD contain some bioactive compounds such as vitamin E (tocopherol and tocotrienols), phytosterol, and squalene. Bioactive compounds of CPO and PFAD are vitamin E, phytosterols, and squalene. Vitamin E of CPO and PFAD mainly comprised of tocotrienols and the remaining is tocopherol. Phytosterols of CPO and PFAD contained beta sitosterol, stigmasterol, and campesterol. Tocotrienols and phytosterols of CPO and PFAD, each can be separated to produce tocotrienol rich fraction and phytosterol rich fraction. Tocotrienol rich fraction from PFAD has both antioxidant and cholesterol lowering properties. Bioactive compounds of PFAD silmultaneously have been proven to improve lipid profile, and have hepatoprotector effect, imunomodulator, antioxidant properties, and lactogenic effect in animal test experiment. It is possible to develop separation of bioactive compounds of CPO and PFAD integratively with the other process that utilizes fatty acid.
A polymorphism in the lysyl oxidase propeptide domain accelerates carcinogen-induced cancer
Authors: de la Cueva Ana , Emmerling Michael , Lim Sarah L , Yang Shi , Trackman Philip C , Sonenshein Gail E , Kirsch Kathrin H 
Published: March 2018

Abstract
The propeptide (LOX-PP) domain of the lysyl oxidase proenzyme was shown to inhibit the transformed phenotype of breast, lung and pancreatic cells in culture and the formation of Her2/neu-driven breast cancer in a xenograft model. A single nucleotide polymorphism (SNP, rs1800449) positioned in a highly conserved region of LOX-PP results in an Arg158Gln substitution (humans). This arginine (Arg)→glutamine (Gln) substitution profoundly impaired the ability of LOX-PP to inhibit the invasive phenotype and xenograft tumor formation. To study the effect of the SNP in vivo, here we established a knock in (KI) mouse line (LOX-PPGln mice) expressing an Arg152Gln substitution corresponding to the human Arg158Gln polymorphism. Breast cancer was induced in wild-type (WT) and LOX-PPGln female mice beginning at 6 weeks of age by treatment with 7,12-dimethylbenz(a)anthracene (DMBA) in combination with progesterone. Time course analysis of tumor development demonstrated earlier tumor onset and shorter overall survival in LOX-PPGln versus WT mice. To further compare the tumor burden in WT and LOX-PPGln mice, inguinal mammary glands from both groups of mice were examined for microscopic lesion formation. LOX-PPGln glands contained more lesions (9.6 versus 6.9 lesions/#4 bilateral). In addition, more DMBA-treated LOX-PPGln mice had increased leukocyte infiltrations in their livers and were moribund compared with DMBA-treated WT mice. Thus, these data indicate that the Arg→Gln substitution in LOX-PP could be an important marker associated with a more aggressive cancer phenotype and that this KI model is ideal for further mechanistic studies regarding the tumor suppressor function of LOX-PP.
Linear decline in red snapper (Lutjanus campechanus) otolith Δ14C extends the utility of the bomb radiocarbon chronometer for fish age validation in the Northern Gulf of Mexico
Authors: Barnett Beverly K , Thornton Laura , Allman Robert , Chanton Jeffrey P , Patterson William F 
Published: March 2018

Abstract
Radiocarbon (Δ14C) was analyzed in northern Gulf of Mexico (nGOM) red snapper (Lutjanus campechanus) otolith cores (n = 23), otolith edge samples (n = 12), and whole age-0 otoliths (n = 9), with edge samples and whole age-0 otoliths constituting known-age samples. There was no significant difference in the linear relationship of Δ14C versus year of formation between regional corals and known-age otolith samples, and a linear regression fit to the combined data from 1980 to 2015 extends the utility of the bomb radiocarbon chronometer for age validation. The entire regional coral and known-age otolith data set (1940 to 2015) was then utilized as a reference series to validate otolith-derived red snapper age estimates for cored otolith samples. A loess regression was fit to the reference data and then the sum of squared residuals (SSR) was computed from predicted versus observed birth years for cored adult otolith samples. This process was then repeated for ages biased ±1–4 years. Ages with no bias applied had the lowest SSR, thus validating red snapper age estimates and demonstrating the utility of the combined regional coral and known-age red snapper otolith Δ14C time series for age validation of nGOM marine fishes.
Ramsey Graphs Induce Subgraphs of Quadratically Many Sizes
Authors: Kwan Matthew , Sudakov Benny 
Published: March 2018

Abstract
An n-vertex graph is called C-Ramsey if it has no clique or independent set of size $C\log n$. All known constructions of Ramsey graphs involve randomness in an essential way, and there is an ongoing line of research towards showing that in fact all Ramsey graphs must obey certain “richness” properties characteristic of random graphs. Motivated by an old problem of Erd̋s and McKay, recently Narayanan, Sahasrabudhe, and Tomon conjectured that for any fixed C, every n-vertex C-Ramsey graph induces subgraphs of $\varTheta (n^{2} )$ different sizes. In this paper we prove this conjecture.
Association of dairy intake with weight change in adolescents undergoing obesity treatment
Authors: Wrotniak Brian H , Georger Lesley , Hill Douglas L , Zemel Babette S , Stettler Nicolas 
Published: March 2018

AbstractBackgroundThe role of dairy products in obesity treatment for adolescents is unclear. The study purpose was to assess the association between dairy intake and changes in BMI z-score (zBMI) during adolescent obesity treatment.MethodsObservational study nested within a randomized control trial. Linear mixed-effects regression models were adjusted for important non-lifestyle factors then further adjusted for dietary and physical activity variables. In total, 91 adolescents were studied.ResultsEach serving of total dairy (β = −0.0054, P < 0.01), unflavored milk (β = −0.012, P < 0.01), reduced fat (β = −0.0078, P < 0.05), and low fat/fat-free products (β = −0.0149, P < 0.01) was associated with a decrease in zBMI over 12 months. These associations were no longer significant after adjustment for other dietary and physical activity factors. Sugar-sweetened beverage intake was inversely associated with intake of total dairy (β = −0.186, P = 0.001), unflavored milk (β = −0.115, P = 0.003) and low fat/fat-free dairy (β = −0.125, P = 0.001).ConclusionsIntakes of total dairy, unflavored milk, reduced fat dairy and low fat/fat-free dairy products are associated with improved obesity treatment outcomes among adolescents. This could be due to co-occurring healthy lifestyle behaviors or to replacement of other food and beverages associated with obesity, such as sugar-sweetened beverages, by dairy products.
Pressure Injury Prevention: Knowledge and Attitudes of Iranian Intensive Care Nurses
Authors: Tirgari Batool , Mirshekari Leili , Forouzi Mansooreh Azzizadeh 
Published: March 2018

ABSTRACT

BACKGROUND:
Pressure injuries are the third most expensive condition after cancer and cardiovascular disease. Nurses are responsible for the direct and continuous care, treatment, and prevention of pressure injuries. To achieve optimal quality care, nursing knowledge and attitudes must be based on the best scientific evidence. This study aimed to examine the knowledge and attitudes of nurses working in intensive care units of hospitals affiliated with Zahedan Medical Sciences University regarding the prevention of pressure injuries.

METHODS:
This was a descriptive analytic study involving 89 critical care nurses. Data analysis was conducted using a 3-part questionnaire: demographic data, knowledge, and attitudes of intensive care nurses toward the prevention of pressure injuries. Collected data were analyzed with SPSS version 19 (IBM, Armonk, New York), using descriptive and inferential statistics (such as Pearson correlation coefficient, independent t test, and analysis of variance).

RESULTS:
The results showed that the mean ± SD score of pressure injury knowledge was 0.44 ± 0.12, and the attitude of participants toward pressure injury prevention was 2.69 ± 0.47. Scores varied widely; “nutrition” showed the highest mean score (0.71 ± 0.45), but “etiology and development” (0.42 ± 0.21) and “classification and observation” (0.42 ± 0.24) showed the lowest mean scores. Of the different aspects of attitudes toward pressure injury prevention, “the impact of pressure injuries” showed the highest mean score (2.95 ± 0.56), and “confidence in the effectiveness of prevention” showed the lowest mean score (2.56 ± 0.46). A statistically significant relationship was observed between pressure injury knowledge and attitudes toward pressure injury prevention (P < .001).

CONCLUSIONS:
Pressure injury prevention is one of many nursing care priorities and is a key indicator of the quality of nursing care. In order to achieve optimal quality care in this area, nurse managers and other administrators should make efforts to improve nursing knowledge and attitudes based on the latest scientific evidence for pressure injury prevention.
Food allergy trends at the crossing among socio-economics, history and geography
Authors: Fiocchi Alessandro , Dahdah Lamia , Fierro Vincenzo , Artesani Maria C. , Valluzzi Rocco 
Published: March 2018

Purpose of review
The epidemiology of food allergy did inspire theories on the reasons for the recent surge of the disease. We offer here a reasoned review on the relationships between the trajectories of human development and the trend of the food allergy epidemics.

Recent findings
The exponential trend of the frequency of food allergy paralleled the explosive acceleration of the human development over the last few decades. Dietary factors have been indicated as responsible for these trends and targeted for potential preventive strategies. Other socio-economic factors have been related to this evolution: solar exposure, climate changes, structure of societies, reproductive choices and societal inequalities.

Summary
The epidemiologic associations of food allergy suggest different causal theories. Future prevention strategies may be predicated not only on dietary interventions, but on wider programmes aimed to restore a human ecology promoting food tolerance.
How to manage food allergy in nursery or school
Authors: Oriel Roxanne C. , Wang Julie 
Published: March 2018

Purpose of review
The aim of this review is to describe effective management strategies in nursery or school based upon research findings.

Recent findings
The prevalence of food allergy and number of emergency department visits for food-related anaphylaxis are increasing in children and adolescents. As there is currently no cure, the most effective strategy to decrease allergic reactions is food allergen avoidance. However, allergic reactions are inevitable in both food allergic children as well as in first-time reactors. Misconceptions exist on the safety of products with advisory labels and questions remain on whether school-wide bans decrease the risk of allergic reactions in school. Recent legislation has prompted schools to consider requiring unassigned epinephrine autoinjectors to better manage those who have allergic reactions in nursery or school.

Summary
A collective effort is required to keep children with food allergies safe at school. Families, healthcare providers, and school personnel should be informed on food allergen avoidance strategies, symptoms consistent with allergic reactions and anaphylaxis, how to respond to allergic reactions, and the impact the diagnosis of food allergy may have on quality of life for affected children and their families.
Do Multiple Mini-Interview and Traditional Interview Scores Differ in Their Associations With Acceptance Offers Within and Across Five California Medical Schools?
Authors: Jerant Anthony , Henderson Mark C. , Griffin Erin , Hall Theodore R. , Kelly Carolyn J. , Peterson Ellena M. , Wofsy David , Franks Peter 
Published: March 2018

Purpose
In single-school studies, multiple mini-interview (MMI) and traditional interview (TI) scores are associated with acceptance offers. Unexamined is whether scores at one school are associated with acceptance at other schools; such analyses would mitigate single-school design biases and better estimate how well interviews capture desired applicant attributes. Using data from the 5 California Longitudinal Evaluation of Admissions Practices (CA-LEAP) medical schools, the authors examined associations of MMI and TI scores with acceptance offers within and across schools.

Method
The analyses included applicants who interviewed at ≥1 CA-LEAP school during the 2011–2013 admissions cycles. Three CA-LEAP schools employed TIs and 2 employed MMIs. Interview scores were standardized (z scores: mean = 0, SD = 1), and associations with acceptance offers were examined within and across schools in analyses stratified by school, adjusting for applicant sociodemographics, academic metrics, year, and total number of interviews.

Results
Of 4,993 applicants interviewed, 428 (8.6%) interviewed at both MMI schools, 681 (13.6%) at ≥2 TI schools, and 1,327 (26.6%) at ≥1 MMI and ≥1 TI school. For each school, acceptance was associated with interview score at that school and also with interview scores at the other 4 schools. Cross-school associations of MMI versus TI scores with acceptance did not differ statistically.

Conclusions
Interview score at a given school was associated with acceptance at the other 4 schools, with no significant differences in associations for MMIs versus TIs. The findings suggest both MMIs and TIs captured attributes valued by admissions teams across CA-LEAP schools.
Orthopaedic Watercraft Injuries: Characterization of Mechanisms, Fractures, and Complications in 216 Injuries
Authors: Christensen Joseph , Spence Sean , Watson David , Shah Anjan , Maxson Benjamin , Infante Anthony , Sanders Roy , Mir Hassan R. 
Published: March 2018

Objective:
To review the orthopaedic injuries from watercraft treated surgically at our institution and report the mechanisms, fractures, and complications encountered.

Design:
Retrospective case series.

Setting:
Level I trauma center.

Patients/Participants:
There were 216 fractures from watercraft in 146 patients. Average age was 33 years (range 4–78 years), there were 68% males (99/146), and 16% of the injuries occurred in children.

Intervention:
Operative fracture fixation.

Main Outcome Measurements:
After IRB approval, data were collected from January 1, 1998, to December 31, 2015, for patients including demographics, watercraft type, mechanism of injury, fracture pattern, infection, organisms, union, and amputation. Descriptive statistics were used.

Results:
There were 130 closed fractures (60%) and 86 open fractures (40%). There were 146 (67%) lower extremity injuries, 49 (23%) upper extremity injuries, and 21 (10%) pelvic injuries. The overall postoperative infection rate was 9% (20/216) and was commonly polymicrobial in nature. The postoperative infection rate in closed fractures was 4% (5/130) and the postoperative infection rate in open fractures was 17% (15/86). Open fractures also had a high proportion of nonunion (8%) and amputation (16%).

Conclusions:
This is the largest reported series of orthopaedic injuries from watercraft. These injuries can be devastating in nature and difficult to manage, particularly when they are open (40%). There is a high rate of postoperative infection (17%), nonunion (8%), and amputation (16%) associated with open orthopaedic watercraft fractures.

Level of Evidence:
Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.