bluuebunny/crossref_metadata_2025_split huggingface dataset:
YAP1 and WWTR1 are required for murine pregnancy initiation
Authors: Moldovan Genna E , Massri Noura , Vegter Erin L , Pauneto-Delgado Ivonne N , Burns Gregory W , Joshi Niraj , Gu Bin , Arora Ripla , Fazleabas Asgerally T 
Published: November 2024

In briefThe HIPPO signaling effectors YAP1 and WWTR1 are required for murine pregnancy initiation, and mutation of these factors compromises the decidualization response and overall pregnancy success.AbstractEndometrial stromal cell decidualization is required for pregnancy success. Although this process is integral to fertility, many of the intricate molecular mechanisms contributing to decidualization remain undefined. One pathway that has been implicated in endometrial stromal cell decidualization in humans in vitro is the HIPPO signaling pathway. Two previously conducted studies showed that the effectors of the HIPPO signaling pathway YAP1 and WWTR1 are required for decidualization of primary endometrial stromal cells in vitro. To investigate the in vivo role of YAP1 and WWTR1 in decidualization and pregnancy initiation, we generated progesterone receptor Cre-mediated mutation of a combination of Yap1 and Wwtr1 alleles. Female Yap1 and Wwtr1 triple allele mutants exhibited subfertility, a compromised decidualization response, decreased endometrial receptivity, delayed embryonic development and a unique transcriptional profile at 7.5 days post-coitus (dpc). Bulk mRNA sequencing revealed aberrant maternal remodeling evidenced by significant alterations in extracellular matrix-encoding genes at 7.5 dpc in mutant dams and enrichment for terms associated with fertility-compromising diseases such as pre-eclampsia and endometriosis. In addition, differentially expressed genes overlapped directionally with estrogen receptor- and epidermal growth factor receptor-regulated genes as identified by microarray. Our results indicate that Yap1 and Wwtr1 are necessary for successful mammalian pregnancy initiation.
State and Local Government Expenditures and Infant Mortality
Authors: Sowmyan Shivani J. , Hirai Ashley H. , Kaufman Jay S. 
Published: November 2024

OBJECTIVES
A previous study reported that increased state and local government expenditures were associated with decreased infant mortality rates (IMRs). However, reported estimates of the association between expenditures and IMR represented the degree to which the association changed each year, not the main effect. We reproduced the original results, reporting this main effect and replicated the analysis using improved methodology and updated data.

METHODS
For the reproduction analysis, we used methods and data identical to the original study: A publicly-posted, state-level data set of expenditures from 2000 to 2014 US Census Bureau survey data linked to 2-year lagged IMR data with a random intercept model including an interaction between time and expenditures. For the replication analysis, we added 5 years of data and adjusted for fixed state differences and inflation.

RESULTS
In the reproduction, the main effects of total, environmental, and educational expenditures on IMR were much larger than the interaction effects previously reported as the main effects. For example, a 1-SD increase in per-capita total expenditures was associated with a reduction of 0.35 infant deaths per 1000 live births instead of 0.02 deaths per 1000 live births originally reported. In the updated replication, the main effects were generally even larger (eg, −0.51 deaths per 1000 per SD increase in total expenditures). Increased total expenditures were associated with absolute but not relative reductions in Black–white IMR gaps.

CONCLUSIONS
State and local government expenditures are associated with greater reductions in IMR than previously reported, underscoring the importance of continued public investment.
A study of metamorphopsia following rhegmatogenous retinal detachment surgery
Authors: Bálint R. , Árpádffy-Lovas T. , Hári-Kovács A. 
Published: November 2024

AbstractPurposeOur objective was to quantitatively investigate metamorphopsia in patients who had undergone pars plana vitrectomy for rhegmatogenous retinal detachment at the Department of Ophthalmology of the University of Szeged. We aimed to compare our findings with perioperative clinical data, and in particular the patients' optical coherence tomography (OCT) results.Materials/MethodsOur study is a retrospective analysis of data from 23 patients who had undergone surgery for retinal detachment. We evaluated best corrected visual acuity (BCVA), metamorphopsia (MM) using M-CHARTS, and macular morphological abnormalities using OCT images in patients who attended regular follow-up visits 1–6 months after the surgery.ResultsThe mean preoperative BCVA of the patients was 0.4, while the mean postoperative BCVA was 0.6, indicating a significant improvement (P = 0.03). We observed a negative correlation between preoperative BCVA and postoperative MM (Pearson's r = −0.27), indicating that lower preoperative BCVA was associated with higher postoperative MM. Additionally, we noted a strong trend between disintegration of the ellipsoid zone (EZ), abnormality of the external limiting membrane (ELM), and MM (P = 0.051 and 0.072 respectively).ConclusionsWhile no significant correlation was found between MM and specific perioperative factors, we observed a notable trend between EZ disintegrity and MM, as well as abnormal ELM and MM. This trend is anticipated to become significant with higher numbers of patients.
Materials beyond monolayers: The magnetic quasi-1D semiconductor CrSBr
Authors: Klein Julian , Ross Frances M. 
Published: November 2024

AbstractThe all-surface nature of atomically thin van der Waals materials can present challenges for practical applications. Fortunately, new layered materials are on the horizon that preserve their useful properties even when thicker than a monolayer. Here, we summarize our interest in one of these emergent materials, the magnetic semiconductor CrSBr. We describe monolayer properties exhibited by this material in its bulk form, discussing how the quasi-1D electronic structure of CrSBr allows mono- or bilayer physics to be displayed even in thick crystals. Long-range magnetic order offers additional tuning with the coupled lattice, spin, orbit, and charge degrees of freedom enabling magneto-correlated phenomena. We discuss the stability of CrSBr in air and show atomic scale structural manipulation through electron beam-driven transformations. We conclude that the stability and structural amenability of CrSBr provide opportunities for imagining devices that use bulk crystals yet exploit unique magnetic and quantum confinement effects.
Graphical abstract
Acoustic correlates of GIVENness in Icelandic: Revisiting the Radical Deaccentuation hypothesis
Authors: Güneş Güliz , Dehé Nicole 
Published: November 2024

This paper discusses whether there is a direct link between GIVENness-related deaccentuation and ellipsis. The idea that ellipsis can only target already-deaccented material with “distinguished low-flat intonation” (Chomsky &amp; Lasnik 1993: 564) is known as the Radical Deaccentuation (RD) account (see e.g. Tancredi 1992). Icelandic represents a challenge for RD, as it permits (clausal) ellipsis (Wood et al. 2016, 2020) yet does not seem to display deaccentuation (Nolan &amp; Jónsdóttir 2001, Dehé 2009). We conducted a prosodic production experiment to investigate the acoustic correlates of post-focal GIVENness in pre-elliptic clauses in Icelandic to determine if Icelandic undermines the RD theory. We found that Icelandic exhibits prosodic attenuation in pre-elliptic clauses, such that pitch accents of given items are realized, yet they exhibit lower overall F0, and shorter duration. We also found a difference in prosodic constituency between all-new and pre-elliptic clauses, such that the given part in only the pre-elliptic condition is structur-ally integrated to the prosodic domain of the focused item. Our empirical findings are compatible with a weaker version of RD, namely one which treats ‘deaccentuation’ as a cover term for any acoustic effect related to the prosodic marking of GIVENness.
Tryptophan-13C11 Supplementation and its Effects on Cannibalism, Growth and Survival of Ompokbimaculatus Post-larvae
Authors: Anamika Debnath , Suparna Deb , Pradyut Biswas 
Published: November 2024

This study examined how Tryptophan-13C11 supplementation to the diet of Ompokbimaculatus post larvae affects cannibalism, survival, and growth. •	Experiment: Post larvae were fed diets with varying Tryptophan-13C11levels (0%, 0.5%, 1%, 2%, 4%) for 30 days. •	Stocking density: 10 days old post-larvae were stocked @ 10 post-larval-1 •	Experimental period: 30 days Findings: •	Tryptophan-13C11 increased serotonin levels in the fish and slightly decreased growth rate. •	Survival rates were higher in groups fed Tryptophan-13C11diets. Conclusion: Dietary Tryptophan-13C11 can be a useful tool to improve survival rate in O. bimaculatus post larvae rearing. However, it may slightly impact growth rates.
Imaging Complex Structures of the Los Angeles Basin via Adjoint-State Travel-Time Tomography
Authors: Wang Dan , Hao Shijie , Chen Jing , Song Guojie , Tong Ping 
Published: November 2024

ABSTRACT
In this study, we present high-resolution seismic velocity models for the Los Angeles basin (LAB) and its adjacent area using adjoint-state travel-time tomography, fitting an extensive database of P- and S-wave travel times accumulated from 1980 to 2021. We select 151,193 first P-wave travel times and 149,997 first S-wave travel times from local earthquakes archived in the Southern California Earthquake Data Center to determine the velocity models, with earthquake locations updated at each iteration. With seismic stations spaced more than 3.5 km apart, our dataset has limited resolution in the uppermost 1–2 km. However, starting from three different initial models, our VP models, which are optimally imaged between 3 and 15 km, show similar velocity heterogeneity and provide a better fit to the observed first travel-time data compared to the Community Velocity Model-Harvard 15.1.0 and Community Velocity Model-Southern California Earthquake Center 4.26. Our models provide a detailed delineation of the subsurface structure beneath the LAB, revealing significant velocity variations across active faults, a 10-km-thick sequence of sedimentary rocks within the basin, and a distinct basin margin marked by transitions from low to high-velocities. In addition, these models highlight basement structures with elevated VP and VS located at depths of 9 to 12 km and beyond. Specifically, beneath the northeastern part of the basin, the models demonstrate improved accuracy and reliability in reflecting the linear relationship between VP and VS in mafic rocks. The accurate delineation of the basin’s structure provided by our models could also offer robust constraints for seismic response modeling and seismic hazard assessment in the region.
Reverse drilling v/s Conventional drilling: Expounding the concept of osseodensification - A narrative review
Authors: Perween Naila , Sachdeva Shabina , Kapoor Pranav 
Published: November 2024

Achieving optimal primary stability during surgical implant placement is essential for successful implant rehabilitation. Several factors, both biomechanical and clinical, influence implant stability. Among these factors, the quality of the surrounding bone and the surgical technique employed play significant roles.. In order to maintain sufficient bulk and density to achieve the desired bone to implant contact, several surgical techniques have been proposed in such low quality bone. One such innovative technique gaining attention is Osseodensification, which is a non-subtractive drilling technique that utilizes specially designed drills in a counterclockwise direction. This technique is designed to preserve bone integrity while inducing controlled plastic deformation of the surrounding bone. Additionally, Osseodensification facilitates compaction autografting, wherein bone particles are compacted within the osteotomy site, further enhancing primary stability. This review aims to provide insights into the array of techniques available for improving primary stability in low-density bone, with emphasis on the novel Osseodensification procedure.
A comparative evaluation of retention capacity of different dental implant supported overdenture attachment systems- An in vitro study
Authors: Shamim Saimah , Joshi Mridula , Mishra Mangal , Bedia Sumit , Ghadage Mahesh , Shetty Uttam 
Published: November 2024

The most common way to treat full edentulism is with a complete denture. In the mandible as opposed to the maxilla, there is greater worry over the durability and retention of a traditional complete denture. The mandibular arch's decreased surface area for support and retention is the main cause of this. For a fully edentulous mandible, implant-supported overdentures are a reliable course of treatment.This in-vitro study aimed at comparing the retentive capacity of Ball, Locator and OT Equator Implant supported overdenture attachment system when subjected to 14600 cycles of insertion and de-insertion.Fifteen mandibular dentures were fabricated with heat polymerized polymethyl methacrylate resin to test the retentive capacity of Ball, Locator and OT Equator attachment system. Metal housing with retentive nylon caps were picked up in all the sample using cold cure acrylic resin. The samples were subjected to fatigue testing and only monodirectional force was applied. Ball, Locator and OT Equator attachment system sample were subjected to 14,600 insertion/ de insertion cycle on Universal Testing Machine and data was recorded and statistical analysis was done. All the three groups showed significant differences. The retentive capacity of the Ball attachments lasts longer than that of the Locator and Equator attachments. After ten years of use, All three systems continue to have clinically acceptable retention.
What Counts as Global Health?
Authors: Macdonald Margaret 
Published: November 2024

Safe abortion access is an essential aspect of reproductive justice and key to reducing global rates of maternal mortality, yet within the global heath enterprise, the rhetoric of sexual and reproductive health and rights has not yet been realised in practice. Access to safe legal abortion remains inequitable globally and within nations and deaths due to unsafe abortion take their highest toll in the Global South in jurisdictions with restrictive laws. Clandestine abortion access activist networks have been filling this gap offering life, dignity and futures to the people who seek their services. What should we make of clandestine activist networks around the world that help people access medication abortion? Such groups have been important players in women’s reproductive health in many jurisdictions for decades – but have typically, by necessity and design, flown under the radar. If visibility, accountability and humanitarian appeal are essential characteristic of global health work, how do we acknowledge and understand the work of clandestine abortion access activist networks? Does it count as global health? In this essay I offer the notion of ‘critique in action’ to further our understanding of such networks and also consider the idea of abortion access activist networks as an anti-regime of global health.
Background of Fost Children in The Raudhatul Yatama Orphanage, Kertak Hanyar District, Banjar District
Authors: Rosalini Isabella , Abbas Ersis Warmansyah , Jumriani Jumriani , Triyono Sigit , Sari Raihanah 
Published: November 2024

This study aims to: 1) Describe the background of foster children in the Raudhatul Yatama Orphanage, Kertak Hanyar District, Banjar Regency. 2) Describe the parenting style of foster children at the Raudhatul Yatama Orphanage, Kertak Hanyar District, Banjar Regency. 3) Describe the contribution of parental parenting to social studies education. This study uses a qualitative research method with a descriptive approach. The data collection techniques used are observation, interviews, and documentation. Data analysis uses data reduction, data presentation and conclusion drawn. Test the validity of the data using triangulation. The results of the study were that children living in the Raudhatul Yatama Orphanage, Kertak Hanyar District, Banjar Regency came from various diverse backgrounds, including orphans, orphans, underprivileged, and abandoned children. This orphanage accepts 30 children with various age ranges. Data collection is expected to help orphanages to understand the needs and obstacles faced by these children. The orphanage management pays attention to children from these backgrounds. The orphanage is committed to providing the best care and education to all foster children, regardless of their family origin or background.
Assessment of Health Disparities and Sexual Orientation Response Choices Used in Two US National Population-Based Health Surveys, 2020‒2021
Authors: Kahn Nicole F. , Halpern Carolyn T. , Burshell Dana R. , Hernandez Stephanie M. , Conron Kerith J. 
Published: November 2024

Objectives. To (1) compare responses to 2 survey questions designed to measure sexual orientation and (2) understand how variation in responses is associated with mental health. Methods. Data were from the National Longitudinal Study of Adolescent to Adult Health (Add Health) Sexual Orientation/Gender Identity, Socioeconomic Status, and Health Across the Life Course (SOGI-SES) study (2020–2021) in the United States. We used the adjusted Wald test to compare proportions of respondents who were (1) categorized as heterosexual or straight and sexual minorities using the sexual orientation questions designed for the Add Health study and the National Health Interview Survey (NHIS) and (2) diagnosed with depression or anxiety or panic disorder. Results. The Add Health question detected more than twice as many sexual minority respondents as the NHIS question. Those who responded as sexual minorities to the Add Health question but as heterosexual or straight to the NHIS question, primarily “mostly heterosexuals,” had mental health outcomes that were more like those who were consistently classified as sexual minorities versus those consistently classified as heterosexual or straight. Conclusions. Current measures of sexual orientation in national-level surveys may underestimate the sexual minority population and sexual orientation‒related health disparities. Public Health Implications. Results illustrate the need for further research to expand measurement of sexual orientation on population-based health surveys. ( Am J Public Health. 2024;114(12):1375–1383. https://doi.org/10.2105/AJPH.2024.307839 )
Determining Maximal Outcome Improvement Thresholds for Patient-Reported Outcome Measures After Primary ACL Reconstruction
Authors: Zhang Zhi-yu , Shi Wei-li , Bai Wen-bin , Hong Le-jin , Dai Wen-li , Pan Xiao-yu , Fu Xiao-yue , Wang Jian-quan , Wang Cheng 
Published: November 2024

Background:
The clinical interpretation of patient-reported outcome measures (PROMs) after anterior cruciate ligament (ACL) reconstruction (ACLR) can be challenging. This study aimed to establish the clinical relevance of PROMs by determining maximal outcome improvement (MOI) thresholds at mid-term follow-up after primary ACLR.

Methods:
A total of 343 patients who underwent primary single-bundle ACLR using hamstring tendon autograft at our institute were included. Patients were queried with a 2-option anchor question regarding satisfaction with their current knee symptom state. The MOI of a PROM was calculated for each patient as the percentage of improvement normalized by the maximal possible improvement. The MOI threshold for each PROM was determined as the optimal cutoff value for predicting patient satisfaction based on receiver operating characteristic curve analysis. Multivariable logistic regression analyses were performed to identify predictors of achieving these thresholds. Subgroup analyses that stratified the time from injury to surgery within the cohort were performed, and MOI thresholds were recalculated within each of these subgroups. The PROMs evaluated in this study were the modified Lysholm Knee Score and the International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC) score.

Results:
The calculated MOI threshold was 35.1% for the Lysholm score and 46.7% for the IKDC score. A longer time from injury to surgery reduced the odds of achieving the MOI threshold for the Lysholm score (odds ratio [OR] per time bracket = 0.7114, p < 0.0001) and IKDC score (OR = 0.8038, p = 0.0003). Male sex was associated with higher odds of achieving the MOI threshold for the IKDC score (OR = 1.9645, p = 0.0143). For patients with chronicity of ≤6 months, the MOI threshold was 35.1% for the Lysholm score and 57.9% for the IKDC score, and for patients with chronicity of >6 months, the thresholds were 24.5% and 27.1%, respectively.

Conclusions:
The calculated MOI thresholds for the Lysholm and IKDC scores at mid-term follow-up after primary ACLR were 35.1% and 46.7%, respectively. Greater chronicity of the ACL injury was associated with lower odds of achieving the MOI thresholds for the PROMs at mid-term follow-up.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Multicenter Randomized Clinical Trial of Highly Cross-Linked Polyethylene Versus Conventional Polyethylene in 518 Primary TKAs at 10 Years
Authors: Salmons Harold I. , Larson Dirk R. , Ortiguera Cedric J. , Clarke Henry D. , Spangehl Mark J. , Pagnano Mark W. , Stuart Michael J. , Abdel Matthew P. 
Published: November 2024

Background:
Second-generation highly cross-linked polyethylene (HXLPE) has revolutionized total hip arthroplasty. However, the long-term risks and benefits of HXLPE in primary total knee arthroplasty (TKA) remain unknown. This randomized clinical trial evaluated implant survivorship, complications, radiographic results, and clinical outcomes of HXLPE and conventional ultra-high molecular weight polyethylene (UHMWPE) inserts in primary TKAs.

Methods:
We enrolled 518 patients (518 knees) who underwent primary TKA in 3 centers within 1 tertiary referral network. The mean age was 67 years, the mean body mass index was 32 kg/m2, and 58% of the patients were women. All of the patients underwent primary TKA with a cemented posterior-stabilized tibial insert and patellar resurfacing. Randomization proceeded via stratified dynamic allocation. The patients were blinded to their study group allocation: those in the control group (254 knees) underwent TKA with an UHMWPE insert (N2Vac; Stryker); those in the treatment group (264 knees) received an HXLPE insert (X3; Stryker). Kaplan-Meier survivorship, radiographic results, and clinical outcomes were assessed. This trial was registered with ClinicalTrials.gov. The mean follow-up was 11 years.

Results:
The 10-year overall survivorship free from any revision and from any reoperation was 96% and 94%, respectively. There were no differences in the risk of revision or reoperation between the groups (p > 0.05). There were a total of 19 revisions. Revision indications included periprosthetic joint infection (14 knees), instability (4 knees), and open reduction and internal fixation (ORIF) for a patellar fracture due to osteolysis around a UHMWPE insert (1 knee). There were no revisions due to polyethylene wear, osteolysis, or fracture of the post in the HXLPE group. The radiographic results and clinical outcomes were otherwise similar.

Conclusions:
Notably, no wear-related failures were identified in the HXLPE group, but there was 1 case of osteolysis in the UHMWPE group.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.