bluuebunny/crossref_metadata_2025_split huggingface dataset:
HSP90 Contributes to Entrainment of the Arabidopsis Circadian Clock via the Morning Loop
Authors: Davis Amanda M , Ronald James , Ma Zisong , Wilkinson Anthony J , Philippou Koumis , Shindo Takayuki , Queitsch Christine , Davis Seth J 
Published: October 2018

Abstract
The plant circadian clock allows the synchronization of internal physiological responses to match the predicted environment. HSP90.2 is a molecular chaperone that has been previously described as required for the proper functioning of the Arabidopsis oscillator under both ambient and warm temperatures. Here, we have characterized the circadian phenotype of the hsp90.2-3 mutant. As previously reported using pharmacological or RNA interference inhibitors of HSP90 function, we found that hsp90.2-3 lengthens the circadian period and that the observed period lengthening was more exaggerated in warm–cold-entrained seedlings. However, we observed no role for the previously identified interactors of HSP90.2, GIGANTEA and ZEITLUPPE, in HSP90-mediated period lengthening. We constructed phase-response curves (PRCs) in response to warmth pulses to identify the entry point of HSP90.2 to the oscillator. These PRCs revealed that hsp90.2-3 has a circadian defect within the morning. Analysis of the cca1, lhy, prr9, and prr7 mutants revealed a role for CCA1, LHY, and PRR7, but not PRR9, in HSP90.2 action to the circadian oscillator. Overall, we define a potential pathway for how HSP90.2 can entrain the Arabidopsis circadian oscillator.
Effectiveness of Antiemetic Regimens for Highly Emetogenic Chemotherapy-Induced Nausea and Vomiting: A Systematic Review and Network Meta-Analysis
Authors: Yokoe Takamichi , Hayashida Tetsu , Nagayama Aiko , Nakashoji Ayako , Maeda Hinako , Seki Tomoko , Takahashi Maiko , Takano Toshimi , Abe Takayuki , Kitagawa Yuko 
Published: October 2018

Abstract

Background
It is important to control chemotherapy-induced nausea and vomiting (CINV) to maintain dose intensity and patients' quality of life. The National Comprehensive Cancer Network guidelines suggest combination therapy of antiemetic agents. The growing number of antiemetic regimens, and in particular the growing use of regimens containing antagonists to the Nk-1 receptor (NK1RAs) and the antipsychotic drug olanzapine (OLZ), call for the re-evaluation of the optimal regimen for CINV. This study assessed the efficacy and safety of antiemetic regimens for highly emetogenic chemotherapy, using Bayesian network meta-analysis.

Methods
Randomized trials that compared different antiemetic regimens were included. We strictly followed Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The main outcomes were the odds ratio (OR) for overall complete response (absence of vomiting). We conducted network meta-analysis within a Bayesian model to combine the direct and indirect evidence. Safety was assessed from the trial description. All statistical tests were two-sided.

Results
We systematically reviewed 27 randomized control trials (13,356 participants), which compared 12 different antiemetic regimens: serotonin-3 receptor antagonist (5HT3), 5HT3 + dexamethasone (Dex), palonosetron (PAL), PAL + Dex, PAL at 0.75 mg (PAL0.75), PAL0.75 + Dex, NK1RA + 5HT3 + Dex, NK1RA + PAL + Dex, an oral combination of netupitant and palonosetron (NEPA) + Dex, OLZ + 5HT3 + Dex, OLZ + PAL + Dex, and OLZ + NK1RA + 5HT3 + Dex. An NK1RA + 5HT3 + Dex regimen and an NK1RA + palonosetron + Dex regimen gave a higher complete response (CR) rate than the reference regimen, 5HT3 + Dex (OR, 1.75; 95% credibility interval [95% CrI], 1.56–1.97, and OR, 2.25; 95% CrI, 1.66–3.03, respectively). A regimen containing NEPA was more effective in producing CR than conventional regimens without NEPA or olanzapine. Further analysis, based on the surface under the cumulative ranking probability curve, indicated that olanzapine-containing regimens were the most effective in producing CR.

Conclusion
Our meta-analysis supports the conclusion that olanzapine-containing regimens are the most effective for CINV of highly emetogenic chemotherapy. We confirmed that NK1RA + PAL + Dex is the most effective of conventional regimens. Substituting olanzapine for an Nk-1 receptor antagonist may offer a less costly and more effective alternative for patients.
Diseño y validación de una rúbrica de evaluación de las competencias digitales desde la socioformación
Authors: Salazar Gómez Elizabeth , Tobón Sergio , Juárez Hernández Luis G. 
Published: October 2018

Debido a la ausencia de investigaciones e instrumentos que exploren y evalúen las competencias digitales tanto en los contextos educativos como comunitarios, se diseñó una rúbrica de evaluación sobre competencias digitales desde el enfoque socioformativo, con base en lo siguiente: 1) revisión documental de la bibliografía de documentos existentes para diagnosticar o evaluar las competencias digitales; 2) construcción del instrumento mediante una estructura tipo rúbrica con la taxonomía socioformativa; 3) revisión y mejora del instrumento por parte de un grupo de 3 expertos; 4) validación de contenido mediante el juicio de expertos en el área; 5) aplicación del instrumento a un grupo piloto compuesto por 44 personas 6) mejora final del instrumento a partir de las sugerencias de los jueces y su evaluación. A partir de la valoración de los jueces expertos, se realizó un análisis de los datos descriptivos y de acuerdo con el coeficiente de la V de Aiken, en los ítem 4, 5, 6, y 7 se obtuvo un puntaje de (V>0.80), no siendo así para los ítem 1, 2, 3, que reflejaron un puntaje menor (V<0.80) a partir de ello y las sugerencias emitidas por los jueces, el instrumento fue modificado en la pertinencia y redacción; en cuanto al nivel de confiabilidad de acuerdo al valor de Alfa de Cronbach se ubico en .845; lo que permite inferir que el instrumento es confiable; En la evaluación cualitativa se obtuvo una mayor frecuencia de los niveles aceptables y alto en pertinencia y redacción, sugiriendo mejoras en las preguntas y no hubo ninguna sugerencia de eliminar ítems.
To the issue of the use of sodium-lithium countertransport rate in red cell membrane as a prognostic marker of artherial hypertension mordbidity and mortality: an experience of 25-year follow up cohort study
Authors: Makarov M A , Oslopov V N , Ganeeva K I 
Published: October 2018

Aim. The article discusses the results of a long-term cohort study devoted to the search for the possible relationship of arterial hypertension morbidity and mortality with the rate of sodium-lithium countertransport (Na+-Li+-СT) in red cell membrane which is a marker of the structural and functional state of the cell membrane.
Methods. The study of the functional state of cell membranes by determining the maximal rate of Na+-Li+-CT in red cell membrane with quintiles analysis of the rate of Na+-Li+-CT. Screening clinical examination, including registration of blood pressure (BP), ECG study, the study of eyeground vessels, one- and two-dimensional echocardiography (EchoCG), the study of the lipid spectrum of the blood. Analysis of medical records.
Results. Based on the results of long-term follow up of the aging cohort total mortality is not associated with Na+-Li+-СT rate in red cell membrane. At the average age of 50 bimodality is detected in the development of new cases of primary arterial hypertension associated with the values of Na+-Li+-СT rate of the 1st quartile (36-206 micromoles of Li per liter of cells per hour) and 3d quartile (276-347 micromoles of Li per liter of cells per hour). At the average age of cohort of 55.6±6.7 years the distribution of patients with arterial hypertension by quartiles of Na+-Li+-СT rate becomes almost identical with the statistically non-significant prevalence of 4th quartile of Na+-Li+-СT rate.
Conclusion. The expected correlation between mortality among persons with hypertension and membrane disorders determined by the high rate of Na+-Li+-СT was not revealed. However, the tendency to the predominance of mortality at high Na+-Li+-СT rate suggests that with a much larger sample size a significant relationship may be confirmed. The necessity of studying the relationship between mortality from arterial hypertension and high rate of Na+-Li+-СT in female cohorts remains actual. Increasing difference of mortality rate among patients with and without arterial hypertension with high rate of Na+-Li+-СT can indicate the relationship between mortality from arterial hypertension and membrane disorders.
Surgical outcome in chronic otitis media with cholesteatoma
Authors: . Shwetha 
Published: October 2018

<p class="abstract"><strong>Background:</strong> Cholesteatoma is synonymous with active squamous type of disease where there is retraction of pars flaccida or tensa that has retained squamous epithelial debris and is associated with inflammation and the production of pus. This pathology can only be eradicated by meticulous surgery. Our study compares the surgical outcome of intact canal wall vs. canal wall down surgeries done for cholesteatoma.</p><p class="abstract"><strong>Methods:</strong> Prospective study on 42 patients who underwent surgery for cholesteatoma between December 2010 and March 2013 at VIMS, Bellary. </p><p class="abstract"><strong>Results:</strong> The net improvement in ABG in ICW mastoidectomy was 16.03 (±7.5) dB and that in CWD mastoidectomy was 11.39(±7.4) dB with a significant p value of 0.04 as determined by the independent ‘t’ test. The residual disease rate for ICW mastoidectomy was determined as 12% whereas recurrence rate was nil. CWD mastoidectomy had no residual or recurrent disease in the 6-month follow-up period. Postoperative complications were noted in 15% of the study population.</p><p class="ETDBodyText"><strong>Conclusions:</strong> The ICW and CWD surgeries have their own advantages and disadvantages and when performed meticulously both serve the purpose of rendering the patient a safe ear. The ICW procedure leaves behind an anatomically near normal ear and when quality of life concerns needs to be addressed this should be the procedure of choice, with advancement in technology and availability of angled endoscopes which have marched well into otology. The CWD procedure should be reserved to cases presenting with complications and in patients who are more likely to be lost to follow-up.</p>
Impaired Homocysteine Metabolism Associated with High Plasma Interleukin- 17A Levels, a Pro-Atherogenic Marker, in an Endogamous Population of North India
Authors: Kaur Lovejeet , Garg Priyanka Rani , Ghosh Pradeep Kumar , Saraswathy Kallur Nava 
Published: October 2018

Background: Impaired homocysteine me­tabolism (IHM; hyperhomocysteinemia) has been linked with many complex disorders like cardiovascular diseases and immu­nological disturbances. However, studies understanding IHM in light of pro- and anti-atherogeneic markers like Interleukin-17A & -10 (IL-17A & IL-10) and Forkhead box p3 (Foxp3, a master transcription factor) are scarce.Aim: In our present study, we aimed to understand the relation of IHM with plasma IL-17A and IL-10 levels and Foxp3 mRNA expression in peripheral blood mononuclear cells (PBMCs) from an endogamous popula­tion (Jats of Haryana, North India) with high prevalence of IHM without the concur­rence of significant adverse cardiovascular outcomes.Methods: Forty (40) clinically healthy individuals, unrelated up to first cousins, were recruited and were subjected to demographic, physiological and anthropometric profiling, followed by intravenous blood sample collection (fasting) and lipid profiling. Plasma homocysteine levels were estimated and individuals with homocysteine levels ≥ 15umol/L and <15umol/L were categorized as the impaired homocysteine metabolism group (IHM, n=30) and normal homocysteine metabolism group (NHM, n=10) respectively. Plasma folate and vitamin B12 and MTHFR C677T (methylenetetrahydrofolate reductase) polymorphism were detected. Relative mRNA expression of Foxp3 in PBMCs (normalized to 18S) was quantitated using SyBR green technology. Plasma IL-10 & 17 levels were estimated by ELISA assays.Results and Conclusion: None of the physiological, anthropometric and lipid variables were different between the two groups. Foxp3 mRNA expression levels were relatively lower, and plasma IL-10 levels were found to be comparable among IHM and NHM group. However, significantly higher IL-17A levels and relatively high LDL cholesterol levels were present in the IHM group as compared with NHM. Our findings suggest that the Jats of Haryana, North India, exhibiting high levels of homocysteine, might also carry the high IL-17A -pro-atherogenic marker, suggest­ing an increasing burden of pre-morbid condition. This apparently does not reach to significant mortality/morbidity attributed to the counter action or balancing act of IL-10 (an anti-atherogenic marker). This further suggests environment-influenced epigenetic control mechanisms of the tar­geted genes in the present population.Ethn Dis. 2018;28(4):525-530; doi:10.18865/ ed.28.4.525
Simulation and Optimization of CO2 Huff-n-Puff Processes in Tight Oil Reservoir: A Case Study of Chang-7 Tight Oil Reservoirs in Ordos Basin
Authors: Lei Zhengdong , Wu Shuhong , Yu Tao , Ping Yi , Qin He , Yuan Jiangru , Zhu Zhouyuan , Su Hao 
Published: October 2018

Abstract
Advancements in horizontal drilling with hydraulic fracturing have enabled commercial oil production from tight oil reservoirs. However, the primary recovery factor remains very low, usually less than 15%. It is a big challenge to supply formation drive energy to sustain production. After hydraulic fracturing, there is often pre-mature water breakthrough or gas channeling when we inject water or gas. Therefore, CO2 huff-n-puff becomes an attractive option to improve oil recovery in tight oil reservoirs.
Based on typical reservoir and fracture properties in Ordos Long-7 tight oil reservoir, a compositional reservoir simulation model with hydraulic fracture network was established to evaluate the performance of CO2 huff-n-puff enhanced oil recovery (EOR) method. Through numerical simulation, we perform sensitivity study to explore the impacts of operation parameters such as CO2 injection rate, injection time, soaking time, number of huff-n-puff cycles on EOR performance. Some of these parameters have rarely been investigated for recovery in tight reservoirs, such as in-situ fluid composition, fracture pore volume and hydraulic fracture characterization. Furthermore, correlation analysis is used to evaluate the performance of CO2 huff-n-puff process.
In this study, we find that hydraulic fracture morphology and fracture conductivity can have a large impact on the performance of CO2 huff-n-puff. Due to the existence of natural fractures in tight reservoirs and the stimulated reservoir volume, CO2 huff-n-puff can not only mobilize the crude oil near the well, but also have certain recovery effects on the remaining oil between the adjacent wells. Simulation results show that the most important parameter is number of cycles, followed by CO2 injection rate and soaking time. It is found that the optimum injection pressure of CO2 huff-n-puff process can be set around the minimum miscibility pressure (MMP) for CO2 and the crude. We set the soaking time period to be 30 days, injection rate to be 150 ton/day, number of cycles to be 4 for optimized oil recovery. The incremental oil recovery factor after one cycle is 1.59%, and the output-to-input ratio is 1:1.75.
The findings in this work have the potential to advance our understandings of the role of CO2 EOR in developing unconventional oil reservoirs, which will benefit both the energy industry and the environment with the potential benefit of CO2 geological sequestration.
Foam Cementing in Australian Coal Seam Gas Operations
Authors: Saunders Troy , Shaban Alex , Zaman Mohammad 
Published: October 2018

Abstract
The Australian coal seam gas (CSG)/coal bed methane (CBM) fields present multiple challenges (i.e., losses, naturally fractured formations, and highly depleted zones) typically addressed using various well design and cementing techniques (i.e., additional casing strings, stage cementers/tools, lost-circulation materials, lightweight designs, and additional cement volume) to manage the potential risk of losses.
Foamed cement is a viable option to address these challenges; however, despite the documented benefits, its application within Australia has been minimal at best. The lack of application can be primarily attributed to misconceptions concerning cost, potential risk, excessive equipment footprint, and a limited proven track record, which increases the potential risk of execution.
A recent 10-well campaign conducted within the Bowen Basin, Queensland, Australia, demonstrated that foamed cement can be used as an alternative to traditional lightweight and/or elastomeric cement slurries. Further, the benefits of foamed cement make it an economically and technically advantageous solution compared to conventional cementing techniques used to overcome CSG challenges.
This case study details the campaign challenges, cement design, and detailed results of the 10 wells with the intention of providing other engineers a road map to better understand foamed cementing with a specific Australian context and how it could be applied to their projects.
The Permian Deep Coal Play, Cooper Basin, Australia. Unlocking the Next Gas Giant
Authors: Cooper Gareth , Lockhart Duncan , Walsh Ainslie 
Published: October 2018

Abstract
Unconventional gas exploration in the Cooper Basin, Australia, has historically concentrated on fracture stimulation of tight gas sandstones within mapped structural closures. In drilling these sandstones, and other clastic reservoir targets, it has been recognised for many years that the Permian coal measures of the Toolachee, Epsilon and Patchawarra Formations record high levels of gas, often in excess of 4000 units, encountered at depths between 2500 and 3500m. Unlike shallower Coal-Seam-Gas reservoirs, which rely on de-pressuristion through de-watering to liberate adsorbed gas from the kerogen surface, deep coals are a "dry" system in which the free gas component is produced via kerogen and fracture permeability.
However maintaining a consistent and commercial flow rate from deep coals alone remained enigmatic until the first dedicated fracture stimulation program of deep Permian coals was commenced in the Moomba Field in 2007. Understandings of Permian source-rock reservoirs, the roles of the coal type and rank on sorption capacity and porosity, the influence of effective pressure and depth on coal permeability and the interrelation of coal fracture permeability with in-situ stress and mechanical stratigraphy has now advanced.
The deep Permian coal fairway in the Patchawarra and Nappamerri Trough of the Cooper Basin has been defined and mapped using a generative potential approach within a comprehensive 3D basin model. Net coal thicknesses from log electro-facies for 879 wells has been combined with available well maturity, TOC, HI and kerogen kinetic data, and calibrated against corrected temperatures in a basin-wide Trinity retention model which incorporates 14 mapped regional horizons. Play fairways have been overlain with observations of in-situ stress direction and fracture orientations from 3D seismic curvature volumes, FMI data and stress states from Mechanical Earth Models (MEM).
Within the basin, this approach has defined a P50 in-place resource of 14.6 TCF of gas and a P10 of 20.7 TCF of gas within the deep coals of the Permian Toolachee, Epsilon and Patchawarra Formations in Senex permits, of which 8-11 TCF is within the North Patchawarra Trough. MEM's have also demonstrated that deep coal seams are consistently in a normal stress state and therefore provide excellent scope for both propagating and constraining vertical fracture growth. Work is now underway to define further those areas, within the mapped resource parameters, which provide the best opportunity to site pilot lateral wells for multi-stage fracture stimulation within deep coals.
Re-defining the Potential-Determining-Ions PDIs for Low Salinity Effect LSE based on Oil/Brine/Solid Interfacial Behaviors and Oil Water Relative Permeability
Authors: Wei Bing , Zhang Xiang , Lu Laiming , Xu Xingguang , Yang Yang , Chen Bin 
Published: October 2018

Abstract
Although the low salinity effect (LSE) in enhanced oil recovery (EOR) is widely accepted, its underlying mechanisms have not conclusively determined largely due to the complex interactions at oil/brine/rock interfaces and their relation with the dynamic flow behaviors in porous media. Given the vast diversity of brine composition in different reservoirs, the current studies are not yet sufficient to map the complicate interfacial behaviors. Therefore, the attention of this work was placed on the events that occurred on oil/brine/rock interfaces through direct measurements of oil water IFTs, interfacial dilational rheology, zeta potential and oil water relative permeability in sandstone porous media. The effect of brine composition including ion types, salinity and valency on LSWF was examined for the intent of re-defining the potential-determining-ions (PDIs) for LSE. The results showed that the oil water interfacial behaviors closely depended on the brine composition. The wettability alteration of the sandstone surface was found to be associated with the divalent ions and the double layer expansion (DLE) failed to interpreted the observed wettability in our work. The injection of MgSO4 brine produced the highest oil recovery factor compared to other three brine. On the basis of the previous observations, we concluded that the LSE was strongly dependent on the events occurred on the oil-brine-solid interfaces. The most significant LSE was observed at a salinity of 2000ppm in our work and the ions of Mg2+ and SO42− appeared to be critical for LSWF.
A Particulate Gel Based System for Water Shut-Off Applications
Authors: Lafitte Valerie , Panga Mohan Kanaka , Vaidya Nirupama , Nikolaev Max , Enkababian Philippe , Teng Ling Kong , Zhao Haiyan 
Published: October 2018

Abstract
Water production is a major concern for oil companies because it involves not only a high cost for handling the water on surface, but also issues related to scale and corrosion in tubulars, and an overall decrease of hydrocarbon production. Finding the right solutions for each case is a challenge because there is no one solution that fits all. Chemical treatments for water shutoff are cheaper than mechanical treatments and can offer more targeted and customized design, but they often come with higher operational risks.
A new water control system based on a single particulate additive was extensively evaluated under laboratory conditions and then successfully implemented in the field. The fluid is easy to prepare using traditional field mixers and does not need curing after it is pumped into the formation, thus saving time and cost compared to most conventional water shutoff systems. The fluid was evaluated in the laboratory with a wide range of formation permeabilities and injection conditions using the fluid loss apparatus, permeameter, and formation response tester. The viscosity and stability of the fluid in different water salinity and concentrations were also investigated.
Overall, it was found that the new fluid system was very efficient in shutting-off formations greater than 50 md up to a few darcies. Those results were consistent with the nature of the plugging mechanism, which relies on physical pore plugging alone. The system could be further tuned depending on the formation permeability. In the presence of oil saturation, the penetration of the particulate system was found limited as compared to a single-phase, water-saturated core.