bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Auckland MA Sociology (Option II- Social Welfare and Development): A social work qualification gone but not forgotten
Authors: Staniforth Barbara 
Published: August 2019

INTRODUCTION: The University of Auckland MA in Sociology (Option II–Social Welfare and Development) (“the Programme”) was a qualifying social work programme that admitted students from 1975 to 1979. This article describes this programme and some of the issues that led to its short-lived tenure.METHODS: Semi-structured interviews were conducted with 12 staff and students who had been involved with this programme. One person, involved in the accreditation of the Programme was also interviewed, and one person provided feedback in an email. Information was also obtained through archived University of Auckland documents, reports, and various forms of personal correspondence provided by June Kendrick. FINDINGS: The Programme was championed by the Head of the Department of Sociology (David Pitt). There were resource limitations and philosophical tensions within the Department about the qualification. There was little support for its continuation at the end of a three-year grant and after the departure of David Pitt. The New Zealand Social Work Training Council accredited it after its discontinuation.CONCLUSION: The Programme made a valuable contribution to the profession of social work and social work education and forms an important part of the history of social work in Aotearoa New Zealand.
Culturally relevant pedagogy for social work learning in Papua New Guinea: Perspectives from the University of Papua New Guinea’s fieldwork programme
Authors: Lawihin Dunstan 
Published: August 2019

INTRODUCTION: Social work education was introduced in the early 1970s in Papua New Guinea (PNG) and is still developing. Subsequently, its teaching and learning approaches have developed and, significantly, applied with greater flexibility than a standardised format although contemporary western methods predominate. METHOD: The centrality of the PNG context for culturally relevant social work education and the paradigms of pedagogy in field education are discussed. PNG worldviews of teaching and learning have links to similar educational and practice perspectives from the Melanesian region, Pacific and other relevant non-western contexts.CONCLUSIONS: PNG’s ways of teaching and learning are yet to become formally integrated into contemporary social work education due to issues of credibility, relevance and quality assurance regarding professional social work values. The article argues for substantial integration and utilisation of traditional PNG-specific methods of teaching and learning in the delivery of social work education at the University of Papua New Guinea (UPNG) as important steps in developing the profession in the country. Indigenous local knowledge and practices of teaching and learning should become integrated into formal classroom pedagogical strategies in social work.
Australian students going to the Pacific Islands: International social work placements and learning across Oceania
Authors: Ravulo Jioji 
Published: August 2019

INTRODUCTION: This paper explores various issues pertinent to international social work practice, including its definition, how Western epistemologies affect international placements, barriers to effective placements and student motivations for undertaking practicum away from home. METHOD: Reviewed literature will be coupled with Australian student-participants’ evaluations of their experience in completing social work placements in Fiji and Samoa. FINDINGS: A new model of approaching Pacific social work across Oceania emerges from the study. Entitled Tanoa Ni Veiqaravi(Serving Bowl of Serving Others), this culturally nuanced framework integrates both Western and Pacific social work perspectives to support professional practice, policy development and research across the region.CONCLUSIONS: Recommendations for the improvement of international field practice are offered.
Grandparents battle to be key stakeholders in protecting grandchildren
Authors: Gair Susan , Zuchowski Ines 
Published: August 2019

INTRODUCTION: Grandparents are increasingly involved in the care of grandchildren, including after child protection intervention.METHOD: A recent Australian qualitative research partnership explored how relationships between grandparents and their grandchildren could be optimised after child safety concerns. Interviews and focus groups were undertaken with 77 participants, including 51 grandparents, 12 parents, six foster carers and eight child and family workers. Emerging themes reported here focus on the role of grandparents and their perceptions of, and interactions with, the child protection system.FINDINGS: Overall, findings identify that grandparents wanted to help safeguard their grandchildren but many encountered an adversarial child protection system that left them feeling powerless, fearful and unimportant. Aboriginal participants reiterated that child protection workers needed to better understand how maintaining kinship networks provided a protective factor for Aboriginal children, and that grandparents were key stakeholders in their grandchildren’s lives.IMPLICATIONS: The findings from this study affirm the value and role of grandparents and highlight the need for implemented family-inclusive child protection practice within and beyond the Australian context.
Mitochondria—Striking a balance between host and endosymbiont
Authors: Youle Richard J. 
Published: August 2019

Putting a price on the powerhouse
Mitochondria—the so-called powerhouse of the cell—are derived from bacterial endosymbionts. This history provides opportunities and challenges for their host cells, particularly metazoans, including humans. Youle reviews the interplay between host and mitochondrial biology and highlights how mitochondrial ancestry has influenced innate immune responses. Keeping mitochondria both healthy and in check is key to organismal health and, when perturbed, leads to a variety of pathologies, including Parkinson's disease and inflammation.

Science
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SEIMLESS: Simultaneous Extracranial, Intracranial Management of (tandem) LESsions in Stroke
Authors: Sultan-Qurraie Ali , Witt Taylor , de Havenon Adam , Ribo Marc , Zaidat Osama O 
Published: August 2019

BackgroundPooled individual data from the landmark stroke trials of 2015 conclude that the benefit of endovascular thrombectomy for patients with intracranial arterial occlusion also extends to patients with concomitant (so-called ’tandem') occlusions of proximal vessels. However, there is heterogeneity and debate in the management of these patients, without a clear standard of care. In particular, there is contention regarding whether the proximal or distal lesion should be treated first. We present a case control study and describe the Simultaneous Extracranial, Intracranial Management of (tandem) LESsions in Stroke (SEIMLESS) technique, an efficient approach to the acute ischemic stroke (AIS) patient who presents with tandem lesions (TLs).MethodsWe describe 5 patients, presenting with AIS and TLs between 2015 and 2017, who we treated with SEIMLESS. Cases were reviewed for clinical data, including arterial puncture to intracranial reperfusion, total fluoroscopy time, amount of contrast, age, and gender. Our series was matched to 5 patients treated with the standard ’sequential' approach (angioplasty followed by thrombectomy) in the same time period by the same operator.ResultsArterial access to intracranial recanalization time was significantly shorter in patients treated with SEIMLESS versus those who had angioplasty followed by thrombectomy (39.6±5.9 min vs 85.2±20.6 min; P=0.014). Patients treated ’seimlessly' also received significantly less iodinated contrast (117±13.5 mL vs 213±48.9 mL; P=0.005) and significantly less fluoroscopy time (21.1±5.2 min vs 55.9±17.8 min; P=0.003). There was no difference in the post-procedural Thrombolysis in Cerebral Infarction score for patients treated with SEIMLESS versus the sequential method (p=0.658).ConclusionSEIMLESS is an efficient procedural method that simultaneously treats a distal intracranial occlusion and a more proximal one. Our small case controlled study finds that this technique is feasible and can lead to faster intracranial recanalization compared with the standard ’sequential' method, utilizing less contrast and radiation in the process. Larger studies are needed to verify our findings.
A2, M2, P2 aneurysms and beyond: results of treatment with pipeline embolization device in 65 patients
Authors: Primiani Christopher T , Ren Zeguang , Kan Peter , Hanel Ricardo , Pereira Vitor Mendes , Lui Wai Man , Goyal Nitin , Elijovich Lucas , Arthur Adam S , Hasan David M , Ortega-Gutierrez Santiago , Samaniego Edgar A , Puri Ajit S , Kuhn Anna L , Orlov Kirill , Kislitsin Dmitry , Gorbatykh Anton , Waqas Muhammad , Levy Elad I , Siddiqui Adnan H , Mokin Maxim 
Published: August 2019

BackgroundIntracranial aneurysms located in the distal vessels are rare and remain a challenge to treat through surgical or endovascular interventions.ObjectiveTo describe a multicenter approach with flow diversion using the pipeline embolization device (PED) for treatment of distal intracranial aneurysms.MethodsCases of distal intracranial aneurysms defined as starting on or beyond the A2 anterior cerebral artery, M2 middle cerebral artery, and P2 posterior cerebral artery segments were included in the final analysis.Results65 patients with distal aneurysms treated with the PED were analyzed. Median aneurysm size at the largest diameter was 7.0 mm, 60% were of a saccular morphology, and 9/65 (13.8%) patients presented in the setting of acute rupture. Angiographic follow-up data were available for 53 patients, with a median follow-up time of 6 months: 44/53 (83%) aneurysms showed complete obliteration, 7/53 (13.2%) showed reduced filling, and 2/53 (3%) showed persistent filling. There was no association between patient characteristics, including aneurysm size (P=0.36), parent vessel diameter (P=0.27), location (P=0.81), morphology (P=0.63), ruptured status on admission (P=0.57), or evidence of angiographic occlusion at the end of the embolization procedure (P=0.49). Clinical outcome data were available for 60/65 patients: 95% (57/60) had good clinical outcome (modified Rankin Scale score of 0–2) at 3 months.ConclusionsThis large multicenter study of patients with A2, M2, and P2 distal aneurysms treated with the PED showed that flow diversion may be an effective treatment approach for this rare type of vascular pathology. The procedural compilation rate of 7.7% indicates the need for further studies as the flow diversion technology constantly evolves.
String geometry and nonperturbative formulation of string theory
Authors: Sato Matsuo 
Published: August 2019

We define string geometry: spaces of superstrings including the interactions, their topologies, charts, and metrics. Trajectories in asymptotic processes on a space of strings reproduce the right moduli space of the super-Riemann surfaces in a target manifold. Based on the string geometry, we define Einstein–Hilbert action coupled with gauge fields, and formulate superstring theory nonperturbatively by summing over metrics and the gauge fields on the spaces of strings. This theory does not depend on backgrounds. The theory has a supersymmetry as a part of the diffeomorphisms symmetry on the superstring manifolds. We derive the all-order perturbative scattering amplitudes that possess the super moduli in type IIA, type IIB and SO(32) type I superstring theories from the single theory, by considering fluctuations around fixed backgrounds representing type IIA, type IIB and SO(32) type I perturbative vacua, respectively. The theory predicts that we can see a string if we microscopically observe not only a particle but also a point in the space–time. That is, this theory unifies particles and the space–time. This paper is a summary version of Ref. 1.
Intense X-ray isolated attosecond pulse generation by using low-intensity chirped pulse combined with a UV seeding pulse
Authors: Li Yi , Castle R. S. , Feng Liqiang 
Published: August 2019

We theoretically investigate intense isolated attosecond pulse (IAP) generation from high-order harmonic generation (HHG) driven by a low-intensity chirped pulse combined with a UV seeding pulse. The results show that, driven by a two-color chirped pulse, the harmonic cutoff can be remarkably extended and a spectral continuum in X-ray region can be obtained. Moreover, as the pulse duration increases or the delay time of the two pulses changes, a larger harmonic cutoff can be found. Further, with the introduction of a UV seeding pulse, the efficiency of HHG can be enhanced by three orders of magnitudes due to the UV resonance ionization. Moreover, as the UV pulse intensity increases, the enhanced ratio of HHG yield can be further improved. The enhancement of HHG yield is related to the pulse duration and delay time of the UV pulse. For instance, when adding a shorter duration UV pulse, the enhancement of HHG is dependent on the delay time of the UV pulse. However, when adding a longer duration UV pulse, the HHG enhancement is not very sensitive to the delay time of the UV pulse. Finally, the obtained spectral continuum supports the generation of intense IAP with the duration of 36 as.
Effect of acute and chronic xenon inhalation on erythropoietin, hematological parameters, and athletic performance
Authors: Dias Katrin A. , Lawley Justin S. , Gatterer Hannes , Howden Erin J. , Sarma Satyam , Cornwell William K. , Hearon Christopher M. , Samels Mitchel , Everding Braden , Liang Allan Shuo-Wen , Hendrix Max , Piper Thomas , Thevis Mario , Bruick Richard K. , Levine Benjamin D. 
Published: August 2019

This study aimed to assess the efficacy of acute subanesthetic dosages of xenon inhalation to cause erythropoiesis and determine the effect of chronic xenon dosing on hematological parameters and athletic performance. To assess the acute effects, seven subjects breathed three subanesthetic concentrations of xenon: 30% fraction of inspired xenon (FiXe) for 20 min, 50% FiXe for 5 min, and 70% FiXe for 2 min. Erythropoietin (EPO) was measured at baseline, during, and after xenon inhalation. To determine the chronic effects, eight subjects breathed 70% FiXe for 2 min on 7 consecutive days, and EPO, total blood, and plasma volume were measured. Phase II involved assessment of 12 subjects for EPO, total blood volume, maximal oxygen uptake, and 3-km time before and after random assignment to 4 wk of xenon or sham gas inhalation. FiXe 50% and 70% stimulated an increase in EPO at 6 h [+2.3 mIU/mL; 95% confidence interval (CI) 0.1–4.5; P = 0.038] and at 192 h postinhalation (+2.9 mIU/mL; 95% CI 0.6–5.1; P = 0.017), respectively. Seven consecutive days of dosing significantly elevated plasma volume (+491 mL; 95% CI 194–789; P = 0.002). Phase II showed no significant effect on EPO, hemoglobin mass, plasma volume, maximal oxygen uptake, or 3-km time. Acute exposure to subanesthetic doses of xenon caused a consistent increase in EPO, and 7 consecutive days of xenon inhalation significantly expanded plasma volume. However, this physiological response appeared to be transient, and 4 wk of xenon inhalation did not stimulate increases in plasma volume or erythropoiesis, leaving cardiorespiratory fitness and athletic performance unchanged. NEW & NOTEWORTHY This is the first study to examine each element of the cascade by which xenon inhalation is purported to take effect, starting with measurement of the hypoxia-inducible factor effector, erythropoietin, to hemoglobin mass and blood volume and athletic performance. We found that acute exposure to xenon increased serum erythropoietin concentration, although major markers of erythropoiesis remained unchanged. While daily dosing significantly expanded plasma volume, no physiological or performance benefits were apparent following 4 wk of dosing.
Safety, hemodynamic effects, and detection of acute xenon inhalation: rationale for banning xenon from sport
Authors: Lawley Justin S. , Gatterer Hannes , Dias Katrin A. , Howden Erin J. , Sarma Satyam , Cornwell William K. , Hearon Christopher M. , Samels Mitchel , Everding Braden , Bruick Richard K. , Hendrix Max , Piper Thomas , Thevis Mario , Levine Benjamin D. 
Published: August 2019

This study aimed to quantify the sedative effects, detection rates, and cardiovascular responses to xenon. On 3 occasions, participants breathed xenon (FiXe 30% for 20 min; FiXe 50% for 5 min; FiXe 70% for 2 min) in a nonblinded design. Sedation was monitored by a board-certified anesthesiologist. During 70% xenon, participants were also verbally instructed to operate a manual value with time-to-task failure being recorded. Beat-by-beat hemodynamics were measured continuously by ECG, photoplethysmography, and transcranial Doppler. Over 48 h postadministration, xenon was measured in blood and urine by gas chromatography-mass spectrometry. Xenon caused variable levels of sedation and restlessness. Task failure of the self-operating value occurred at 60–90 s in most individuals. Over the first minute, 50% and 70% xenon caused a substantial reduction in total peripheral resistance ( P < 0.05). All dosages caused an increase in cardiac output ( P < 0.05). By the end of xenon inhalation, slight hypertension was observed after all three doses ( P < 0.05), with an increase in middle cerebral artery velocity ( P < 0.05). Xenon was consistently detected, albeit in trace amounts, up to 3 h after all three doses of xenon inhalation in blood and urine with variable results thereafter. Xenon inhalation caused sedation incompatible with self-operation of a breathing apparatus, thus causing a potential life-threatening condition in the absence of an anesthesiologist. Yet, xenon can only be reliably detected in blood and urine up to 3 h postacute dosing. NEW & NOTEWORTHY Breathing xenon in dosages conceivable for doping purposes (FiXe 30% for 20 min; FiXe 50% for 5 min; FiXe 70% for 2 min) causes an initial rapid fall in total peripheral resistance with tachycardia and thereafter a mild hypertension with elevated middle cerebral artery velocity. These dose duration intervals cause sedation that is incompatible with operating a breathing apparatus and can only be detected in blood and urine samples with a high probability for up to ~3 h.
Interrelationships between pulse arrival time and arterial blood pressure during postural transitions before and after spaceflight
Authors: Wood Katelyn N. , Greaves Danielle K. , Hughson Richard L. 
Published: August 2019

We tested the hypothesis that acute changes in arterial blood pressure (BP) when astronauts moved between supine and standing posture before and after spaceflight can be tracked by beat-to-beat changes in pulse arrival time (PAT). Nine male crewmembers (45 ± 7 yr of age; mean mission length: 165 ± 13 days) participated in a standardized supine-to-sit-to-stand test (5 min-30 s-3 min) before flight and 1 day following return to Earth with continuous monitoring of ECG and finger arterial BP. PAT was determined from the R-wave of the ECG to the foot of the BP waveform. On average, modest cardiovascular deconditioning was detected by ~10 beats/min increase in heart rate in supine and standing posture after spaceflight ( P < 0.05). When looking across the full data collection period, the r2 values between inverse of PAT (1/PAT) and systolic (SBP) and diastolic BP (DBP) varied considerably between individuals (SBP preflight 0.142 ± 0.186, postflight 0.262 ± 0.243). Individual variability was consistent during periods of transition (SBP preflight 0.284 ± 0.324, postflight 0.297 ± 0.269); however, when SBP dropped >20 mmHg, r2 was significant in 5 of 5 preflight tests and 5 of 7 postflight tests. The standard error of the estimate based on a simple linear model during both pre- and postflight testing was 9–11 mmHg for SBP and 6–7 mmHg for DBP. Overall, the results support the hypothesis that PAT tracked dynamic changes in BP. PAT as a noninvasive, nonintrusive surrogate for changes in BP could be developed as an indicator of risk for syncope on return from spaceflight or other Earth-based applications. NEW & NOTEWORTHY Astronauts returning to Earth’s gravity are at increased risk of low blood pressure on standing. Arterial pulse arrival time tracked the decrease in arterial blood pressure on moving from supine to upright posture. Nonintrusive technology providing indicators sensitive to acute changes in blood pressure could act as an early warning system to identify risk for hypotension that place astronauts, or people on Earth, at risk of impaired cognitive performance, fainting, and falls.
Influence of priming exercise on oxygen uptake and muscle deoxygenation kinetics during moderate-intensity cycling in type 2 diabetes
Authors: Rocha Joel , Gildea Norita , O’Shea Donal , Green Simon , Egaña Mikel 
Published: August 2019

The pulmonary oxygen uptake (V̇o2) kinetics during the transition to moderate-intensity exercise is slowed in individuals with type 2 diabetes (T2D), at least in part because of limitations in O2delivery. The present study tested the hypothesis that a prior heavy-intensity warm-up or “priming” exercise (PE) bout would accelerate V̇o2kinetics in T2D, because of a better matching of O2delivery to utilization. Twelve middle-aged individuals with T2D and 12 healthy controls (ND) completed moderate-intensity constant-load cycling bouts either without (Mod A) or with (Mod B) prior PE. The rates of muscle deoxygenation (i.e., deoxygenated hemoglobin and myoglobin concentration, [HHb+Mb]) and oxygenation (i.e., tissue oxygenation index) were continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. The local matching of O2delivery to O2utilization was assessed by the Δ[HHb+Mb]-to-ΔV̇o2ratio. Both groups demonstrated an accelerated V̇O2kinetics response during Mod B compared with Mod A (T2D, 32 ± 9 vs. 42 ± 12 s; ND, 28 ± 9 vs. 34 ± 8 s; means ± SD) and an elevated muscle oxygenation throughout Mod B, whereas the [HHb+Mb] amplitude was greater during Mod B only in individuals with T2D. The [HHb+Mb] kinetics remained unchanged in both groups. In T2D, Mod B was associated with a decrease in the “overshoot” relative to steady state in the Δ[HHb+Mb]-to-ΔV̇o2ratio (1.17 ± 0.17 vs. 1.05 ± 0.15), whereas no overshoot was observed in the control group before (1.04 ± 0.12) or after (1.01 ± 0.12) PE. Our findings support a favorable priming-induced acceleration of the V̇o2kinetics response in middle-aged individuals with uncomplicated T2D attributed to an enhanced matching of microvascular O2delivery to utilization.NEW & NOTEWORTHY Heavy-intensity “priming” exercise (PE) elicited faster pulmonary oxygen uptake (V̇o2) kinetics during moderate-intensity cycling exercise in middle-aged individuals with type 2 diabetes (T2D). This was accompanied by greater near-infrared spectroscopy-derived muscle deoxygenation (i.e., deoxygenated hemoglobin and myoglobin concentration, [HHb+Mb]) responses and a reduced Δ[HHb+Mb]-to-ΔV̇o2ratio. This suggests that the PE-induced acceleration in oxidative metabolism in T2D is a result of greater O2extraction and better matching between O2delivery and utilization.