bluuebunny/crossref_metadata_2025_split huggingface dataset:
A survey of hypothalamic phenotypes identifies molecular and behavioral consequences of MYT1L haploinsufficiency in male and female mice
Authors: Maloney Susan E. , McCullough Katherine B. , Chaturvedi Sneha M. , Selmanovic Din , Chase Rebecca , Chen Jiayang , Wu Doris , Granadillo Jorge L. , Kroll Kristen L. , Dougherty Joseph D. 
Published: November 2024

AbstractThe transcription factor MYT1L supports proper neuronal differentiation and maturation during brain development. MYT1L haploinsufficiency results in a neurodevelopmental disorder characterized by intellectual disability, developmental delay, autism, behavioral disruptions, aggression, obesity and epilepsy. While MYT1L is expressed throughout the brain, how it supports proper neuronal function in distinct regions has not been assessed. Some features of MYT1L Neurodevelopmental Syndrome suggest disruption of hypothalamic function, such as obesity and endocrine issues, and previous research showed changes in hypothalamic neuropeptide expression following knockdown in zebrafish. Here, we leveraged our heterozygousMyt1lmutant, previously shown to recapitulate aspects of the human syndrome such as hyperactivity, social challenges, and obesity, to examine the impact of MYT1L loss on hypothalamic function. Examining the molecular profile of the MYT1L haploinsufficient hypothalamus revealed a similar scale of disruption to previously studied brain regions, yet with region-specific roles for MYT1L, including regulation of neuropeptide systems. Alterations in oxytocin and arginine vasopressin cell numbers were also found. Behaviors studied included maternal care, social group hierarchies, and aggression, all of which were unchanged. Feeding and metabolic markers were also largely unchanged in MYT1L haploinsufficient mice, yet an interaction was observed between diet and MYT1L genotype on weight gain. Our findings here suggest that gross endocrine function was not altered by MYT1L haploinsufficiency, and that key sex-specific behaviors related to proper hypothalamic function remain intact. Further study is needed to understand the functional impact of the altered hypothalamic molecular profile and changes in neuropeptide cell numbers that result from MYT1L haploinsufficiency.
Isolation of an infectious mammalian chu-like virus from tumor cells of the endangered Tasmanian devil (Sarcophilus harrisii)
Authors: Mélade Julien , Harvey Erin , Mahar Jackie E. , Darby Jocelyn M. , Flies Andrew S. , Holmes Edward C. 
Published: November 2024

SUMMARYJingchuvirales(negative-sense RNA viruses) were initially discovered in invertebrates, with both exogenous and endogenous jingchuviruses subsequently identified in fish, reptiles and mammals. To date, jingchuviruses have only been described metagenomically. By screening primary tumor tissues and tumor cell lines from the endangered Tasmanian devil (Sarcophilus harrisii), we isolated Tasmanian devil chu-like virus (TDCV) from cultures of Tasmanian devil facial tumor disease (DFTD) cells. Cell infection experiments demonstrated active virus replication in Tasmanian devil tumor cells, but not mosquito cells. The absence of viral replication in fibroblasts in cell culture and the lack of RNA detection in several organs suggested that replication was associated with tumor cells. Phylogenetic analysis revealed that TDCV likely represents a novel virus family. This is the first isolation of a jingchuvirus, demonstrating their capacity to infect mammalian cells, and providingin vitroavenues to understand the biology of TDCV and its association with tumor cell infection.
Multisensory integration across reference frames with additive feed-forward networks
Authors: Farahmandi Arefeh , Abedi Khoozani Parisa , Blohm Gunnar 
Published: November 2024

AbstractThe integration of multiple sensory inputs is essential for human perception and action in uncertain environments. This process includes reference frame transformations as different sensory signals are encoded in different coordinate systems. Studies have shown multisensory integration in humans is consistent with Bayesian optimal inference. However, neural mechanisms underlying this process are still debated. Different population coding models have been proposed to implement probabilistic inference. This includes a recent suggestion that explicit divisive normalization accounts for empirical principles of multisensory integration. However, whether and how divisive operations are implemented in the brain is not well understood. Indeed, all existing models suffer from the curse of dimensionality and thus fail to scale to real-world problems. Here, we propose an alternative model for multisensory integration that approximates Bayesian inference: a multilayer-feedforward neural network of multisensory integration (MSI) across different reference frames trained on the analytical Bayesian solution. This model displays all empirical principles of multisensory integration and produces similar behavior to that reported in Ventral intraparietal (VIP) neurons in the brain. The model achieved this without a neatly organized and regular connectivity structure between contributing neurons, such as required by explicit divisive normalization. Overall, we show that simple feedforward networks of purely additive units can approximate optimal inference across different reference frames through parallel computing principles. This suggests that it is not necessary for the brain to use explicit divisive normalization to achieve multisensory integration.Significance StatementThis research presents an alternative model to divisive normalization models of multisensory integration in the brain. Our study demonstrates that a feed-forward neural network can achieve optimal multisensory integration across different reference frames without explicitly implementing divisive operations, challenging the long-held assumption that such operations are necessary for multisensory integration. The model displays all the empirical principles of multisensory integration, producing similar behavior to that reported in Ventral intraparietal (VIP) neurons in the brain. This work offers profound insights into the putative neural computations underlying multisensory processing.
Examination of the influence of the integrated mission management system on the pilot’s situational awareness
Authors: Drupka Grzegorz , Grzybowski Piotr , Szczerba Piotr , Bichajło Lesław 
Published: November 2024

Purpose
This paper aims to present research carried out on the influence of GUI graphical elements design for an integrated mission management system (IMMS) display flight planning process.

Design/methodology/approach
Surveys and research were conducted among students/pilots to explore graphic presentation methods for flight planning displays. Guidelines for graphical layout of the IMMS flight planning interface are proposed.

Findings
A research concept was obtained, enabling GUI tests for IMMS using prepared templates and questionnaires.

Practical implications
This study improves cockpit information readability, understanding and presentation, particularly for flight planning elements such as terrain, weather, traffic and zones influencing route organisation.

Social implications
This study targets possible improvements to the flight path planning process in aviation, inducing a reduction in errors related to human factors while processing the visual data on-board.

Originality/value
The study verified the impact of drawing and rendering methods on IMMS flight planning, suggesting that current display methods may be error-prone when showing hazard information from multiple sources on a single screen.
Exploring the impact of information technology integration capability on project management performance in Chinese construction industry: a moderated mediation analysis
Authors: Li Xiaolin , Cheng Liming , Jiao Hongbo , Li Huimin 
Published: November 2024

PurposeThe purpose of this study is to explore whether information technology (IT) integration capability and data sharing can improve project management performance in China’s construction industry under the background of global informatization. Moreover, the authors explore the moderating role of relational governance between IT integration capability and data sharing.Design/methodology/approachA theoretical model based on the research hypotheses proposed in this study was developed, and a questionnaire survey was conducted with 205 professionals. The data collected were analyzed by the structural equation modeling (SEM) technique.FindingsThe results indicate that IT integration capability has a significant and positive impact on project management performance and data sharing. Moreover, data sharing has a significant and positive impact on project management performance, and it plays a mediating role between IT integration capability and project management performance. In addition, relational governance significantly influences the mediating effect of data sharing.Research limitations/implicationsThe data used in this study is from Chinese scenarios, so the research conclusions and application effects based on this are bound to have certain regional limitations. So, a larger sample size from other countries could be selected to test the model. Besides, there are many factors that affect project management performance improving, and the theoretical model proposed in this study may not be fully considered. Therefore, follow-up researchers can consider bringing more suitable variables into their research studies, so that the theoretical research studies can be more in line with the actual project management practice.Originality/valueThis research’s value is as follows: Firstly, this paper broadens the understanding of how IT integration capability, data sharing and relational governance affects project management performance and enriches the literature in the construction management field under the background of global informatization. Secondly, this research provides a detailed governance solution to improve project management performance.
Exploring job competency related to intelligent construction in China using a text mining method
Authors: Yu Jingyu , Wang Jinqiang , Shi Qingyu , Xu Jie , Wang Jingfeng 
Published: November 2024

PurposeThe construction industry is experiencing digital transformation, which is also defined as intelligent construction. With the rise of intelligent construction, job characteristics are changing rapidly. Current knowledge about job competencies required by intelligent construction is lacking. Therefore, the aim of this paper is to explore job competencies related to intelligent construction by text mining recruitment information. It is expected to reveal the trend of talent development for the intelligent construction industry.Design/methodology/approachA total of 375 job advertisements regarding the demanding professionals and industrial workers related to intelligent construction were collected and analyzed to reveal the demands of the current labor market. Different job posts related to intelligent construction were classified into 11 categories. Job competencies were extracted and analyzed using the latent Dirichlet allocation (LDA) model, frequency–inverse document frequency (TF-IDF) algorithm and k-means cluster analysis method. The text mining results identified 10 job competencies.FindingsCurrently, there was a high demand for high-tech talents in the labor market related to intelligent construction. Those high-tech job posts, such as software engineers and R&D staff, required digital technology, R&D skills, electrical automation knowledge and programming capability. Current employees demanding for intelligent construction are expected to be capable of both using information technology and having a general knowledge of the construction industry.Originality/valueThrough text mining of current job advertisements, the overall demand for compound talents in the labor market of intelligent construction were explored. The results provide empirical reference for personnel training and talent cultivation in the development of intelligent construction. Higher educational institutions, human resources professionals, as well as experts that are already employed or aspire to be employed in intelligent construction companies, would benefit from the results of our analysis.
Performance returns from aligning front-end digital technologies and Just-in-Time practices: empirical findings from the Brazilian manufacturing industry
Authors: do Rego Ferreira Lima Mateus , Franco Cíntia Wilke , Benitez Guilherme Brittes 
Published: November 2024

PurposeThe integration of front-end technologies such as automation, process simulation and augmented reality with Just-in-Time (JIT) practices can yield unforeseen outcomes in manufacturing due to complex dynamics. This study examines this integration’s impact on manufacturing firms' performance.Design/methodology/approachWe design a survey questionnaire and distributed it among 353 Brazilian manufacturing firms to conduct our investigation. We utilize a combination of factorial and regression analyses with moderation within our final sample, composed of 262 manufacturing firms. Our goal is to examine the impact of aligning front-end technologies and JIT on the operational and economic performance of these manufacturing firms. We adopt complexity theory as our theoretical framework, recognizing and accommodating the intrinsic unpredictability and uncertainty inherent in complex scenarios such as technology adoption and its interplay with firm culture, adoption time and technology adoption resistance.FindingsOur findings indicate that JIT influences the use of front-end technologies both positively and negatively. Regarding operational performance, JIT has a positive moderation effect on automation and a negative moderation effect on process simulation. Conversely, for economic performance, JIT positively moderates process simulation and negatively moderates automation.Practical implicationsWe provide empirical evidence for managers to carefully assess the compatibility of technology adoption strategies with existing organizational culture and operational practices to maximize performance outcomes.Originality/valueOur study advances complexity theory by elucidating the impacts of integrating front-end digital technologies with JIT practices within the unique scenario of the Brazilian manufacturing industry. More specifically, our theoretical framework offers a new perspective on the unpredictable nature of performance outcomes regarding technology adoption in operations.
A business process management lifecycle framework for continuous improvement towards operational excellence: lessons learned from a longitudinal study in a Brazilian organisation
Authors: Scavarda Luiz Felipe , Ceryno Paula , Azevedo Thais , Goyannes Gusmão Caiado Rodrigo 
Published: November 2024

Purpose
The purpose of this study is to offer a business process management (BPM) framework with information and insights on designing, implementing, using and assessing business processes for continuous improvement towards operational excellence.

Design/methodology/approach
An action research is carried out over two and a half years on the BPM evolution of a Brazilian entertainment organisation.

Findings
Research provides a novel procedural framework towards improving the understanding of how a complete lifecycle approach for BPM can be implemented for continuous improvement, embracing the critical success factors for each lifecycle phase to achieve operational excellence. Information technology and project management are critical success factors resulting in project barriers. Strategic alignment, top management support, collaborative environment, methods and methodology, and focus on users and culture are acknowledged as main enablers. Findings reinforce the importance of an organisation analysis phase to begin the BPM development and highlight the assessment and improvement phase to respond to organisational environment dynamism.

Practical implications
Practitioners can benefit from the lessons learnt and the proposed framework, which serves as a rigorous methodology to achieve operational excellence in their real-world settings.

Originality/value
This paper goes beyond the well-known design and analysis phases of BPM development, generally studied with an individual focus, offering a complete lifecycle approach for continuous improvement, analysing each phase, from the drawing board to its use and evaluation. It counts on an original longitudinal study rather than a single-time assessment study.
Promotion of the 2022 Olympic Winter Games on Chinese and Western social media
Authors: Licen Simon , Cermelj Nastja 
Published: November 2024

PurposeThe 2022 Olympic Winter Games in Beijing were the first sporting mega-event held in a country that limits access to popular Western social networks. Since both domestic and international audiences were crucial for the organizers, the purpose of this study was to identify similarities and differences in content published and engagement generated on the event’s official social media accounts in the months preceding the Olympics.Design/methodology/approachFor 1,200 consecutive original posts published on Facebook, Sina Weibo and Twitter, we coded the time of publication, motivation targeted by the message according to Raney’s typology of motivations for sport spectatorship, multimedia additions and number of likes/reactions, comments and shares.FindingsAll accounts were dominated by posts targeting cognitive motivations. The Weibo profile was much more active and followed. There, 71.5% of content conveyed learning, while the most engaging content provided entertainment. Content on Western networks was more varied but virtually duplicated across networks. The most engaging posts targeted euphoric stress, escape and aesthetic pleasure. Comparable content elicited different engagement on Chinese and Western social media. Graphics and video were the most engaging features on all networks; polls were the least engaging.Research limitations/implicationsAgenda-setting effects of social media content differ across cultures and are co-created by user comments.Originality/valueTo the best of the authors’ knowledge, this is the first cross-cultural comparison of pre-event social media promotion by non-Western sporting mega-event hosts. Organizers diversified content strategies to cater to different audiences and pursue different policy goals. We proved cultural differences in content preference and engagement and showed the relevance of Raney’s typology of sport spectatorship for social media.
The drivers of liquidity risk in the GCC dual banking sector: the impact of the bank’s business model
Authors: Alsharif Mohammad 
Published: November 2024

Purpose
Considering the influence of the bank’s business model, this study aims to explore the drivers of liquidity risk in the dual banking sector of the Gulf Cooperation Council (GCC) using the two new liquidity requirements of Basel III, Net Stable Funding Ratio and Liquidity Coverage Ratio, as indicators of liquidity risk.

Design/methodology/approach
For 61 GCC banks between 2018 and 2022, this study applies the random effects model with an interaction dummy variable technique.

Findings
Islamic banks in the GCC region tend to have a significantly lower level of Basel III liquidity requirements, meaning that they are struggling to meet the new Basel III liquidity requirements as they lack an adequate liquidity risk management framework. The liquidity of GCC banks decreases with size; this relationship is linear for conventional GCC banks but not linear for Islamic banks. Finally, the COVID-19 epidemic has exacerbated liquidity risk for GCC banks, with Islamic banks appearing to be the most impacted. The findings are robust to alternative variable selections and estimation techniques.

Practical implications
The findings provide useful insights to improve liquidity risk management practices in the GCC banking system, especially for Islamic banks. Targeted reforms may be needed to further develop Islamic banks’ liquidity tools and optimize their ability to withstand macroeconomic and systemic shocks.

Originality/value
To the best of the author’s knowledge, no single study considers the new Basel III metrics for bank liquidity or explicitly compares a wide range of liquidity factors for conventional and Islamic banks in the GCC region.
Return and work in rural areas among youth: the roles of local infrastructure and entrepreneurial opportunity
Authors: Thuy Doan Thi , Thanh Pham Tien , Chau Pha Nguyen Hoang , Lan Anh Nguyen Thii 
Published: November 2024

Purpose
A high-quality workforce plays an important role in rural development. However, many well-educated rural-born youths migrate to urban centers in search for better economic opportunity or living standard due to the socio-economic underdevelopment and a lack of good employment opportunity in rural areas. This migration potentially hampers economic activities in these areas. Therefore, encouraging these youth to return and work is important, demanding the attention of local governments. Accordingly, this research aims to examine the role of local infrastructure and entrepreneurial opportunity in enhancing their return-and-work intention.

Design/methodology/approach
Data were collected from rural-born students studying in urban areas. The quantitative analysis was conducted using structural equation modeling, supplemented by qualitative methods.

Findings
Local infrastructure is positively associated with entrepreneurial opportunity and return-to-work intention. Furthermore, entrepreneurial opportunity is positively linked to return-to-work intention. These results indicate the mediating roles of entrepreneurial opportunity in the effects of local infrastructure on return-to-work intention.

Practical implications
This research offers policy implications for policymakers and local governments in developing countries, emphasizing the important roles of local infrastructure, and entrepreneurial opportunity. This can encourage well-educated rural-born youth to return and work in rural areas, thereby contributing to fostering rural development and revitalizing rural communities.

Originality/value
This research represents one of the early attempts to explore the complex relationships among local infrastructure, entrepreneurial opportunity and return-to-work intention in rural areas among well-educated rural-born youth.
Ecosystem-related digital capabilities and radical service innovation: evidence from the Chinese manufacturing industry
Authors: Zhang Yao , Hao Shengbin 
Published: November 2024

PurposeThis study aims to explore the impact of ecosystem-related digital decoupling capability (DDC) and digital integrative capability (DIC) on manufacturing firms’ radical service innovation (RSI) and the moderating effect of strategic flexibility, specifically resource flexibility (RF) and culture flexibility (CF).Design/methodology/approachThis study employed empirical survey data collected from 238 Chinese manufacturing firms to test all hypotheses through hierarchical multiple regression analyses.FindingsDDC and DIC have positive effects on RSI, with DDC exerting a stronger impact. RF and CF strengthen the positive effect of DIC on RSI, whereas CF diminishes DDC’s positive effect on RSI, and RF does not moderate this effect.Practical implicationsManufacturing firms should prioritize developing ecosystem-related DDC and DIC to drive RSI, especially DDC. Managers should improve firms’ RF and CF when leveraging DIC to drive RSI. However, they should minimize the negative impact of CF when leveraging DDC to drive RSI.Originality/valueThis study shifts the service innovation capabilities from the firm to the ecosystem level, opening a new perspective for exploring RSI’s driving mechanism. With RF and CF as the moderators, the findings reveal the contingent impact mechanism of ecosystem-related digital capabilities on RSI, which provides profound insights into the complex role of strategic flexibility in the new contexts.