bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of the clinical and functional state of the nose in patients with chronic polypous rhinosinusitis and impaired sense of smell
Authors: Vladimirova T. Yu. , Volov N. V. , Kurenkov A. V. , Blashentsev M. K. 
Published: November 2024

Introduction. According to EPOS 2020, сhronic rhinosinusitis with nasal polypsis detected in 2–4.3% of the population, in Russia about 1.5 million people suffer from polyposis. In clinical practice, attention is most often paid to indicators of respiratory function. At the same time, the assessment of olfactory impairment characteristic of CRSwNP is carried out only by answering one of the 22 questions of the SNOT-22 questionnaire, and indicators of olfactory function are rarely taken into account when evaluating the results of objective research methods.Aim. To study the features of the clinical and functional state of the nose in patients with chronic rhinosinusitis and impaired sense of smell.Materials and methods. 50 patients with сhronic rhinosinusitis with nasal polypsis were examined. The study included an assessment of the sense of smell using Sniffin Stiks test-12, a study of respiratory function, performing a video endoscopy of the nose, computed tomography of the nose and paranasal sinuses. A comprehensive assessment of the condition was carried out using the SNOT-22 questionnaire.Results. The subjective assessment of the sense of smell by patients with CRSwNP does not always coincide with the results of identification tests. The results of the SNOT-22 questionnaire often depend on the degree of olfactory impairment. Patients with CRSwNP and anosmia are more likely to complain of postnasal congestion, thick nasal discharge and cough than patients with hyposmia, which is consistent with objective research methods.Conclusions. In patients with Ghronic rhinosinusitis with nasal polypsis and varying degrees of olfactory impairment, heterogeneity of the clinical and functional state of the nasal cavity and paranasal sinuses was noted. When interpreting the results of the SNOT-22 questionnaire, it is advisable to use factor analysis, taking into account the patient’s complaints. To plan individual management of patients with CRSwNP, a comprehensive assessment of the sense of smell is necessary, including identification tests, as well as an additional assessment of the results of computed tomography of the nose and paranasal sinuses and a video endoscopic picture of the nose according to generally recognized scales.
On the local treatment of exacerbation of tonsillopharyngitis
Authors: Karpov I. A. , Lengina M. A. , Korkmazov A. M. , Kornova N. V. , Popadyuk V. I. 
Published: November 2024

Introduction. Anatomical and topographic features of abundant pharyngeal innervation, causing pronounced symptoms of exacerbations of tonsillopharyngitis and significantly reducing the well-being of patients, will determine the improvement of treatment.Aim. To evaluate the possibility of using a nonsteroidal anti-inflammatory drug with the flurbiprofen in complex exacerbations of chronic tonsillopharyngitis.Materials and methods. The clinical observation of 117 patients with exacerbation of chronic tonsillopharyngitis was carried out. By random sampling, all patients were divided into 2 groups, where persons of the main group (n = 61) for standard conservative therapy took a tableted nonsteroidal anti-inflammatory drug with the active substance flurbiprofen 1 tablet with a 3-6-hour time interval during.Results and discussion. On day 3 of the therapy, a more pronounced improvement in both the severity of clinical complaints and pharyngoscopy data was noted to a greater extent in patients of the main group: a decrease in the severity of edema of the palatine tonsils by 1.6 points, vascular injection by 1.8 points, edema of the palatine arches by 2.2 points, hyperemia of the mucous membrane by 3.7 points. In the Conrol group (n = 56), there was a decrease in the severity of edema of the palatine tonsils by 1.4 points, vascular injection by 1.2 points, edema of the palatine arches by 1.7 points, hyperemia of the mucous membrane by 2.4 points. During the 7-day course of treatment, psychological health was restored by 24.8 points in the control group and by 32.3 points in the main group. An increase in vital activity was noted by 18.7 points in the control group and by 34.2 points in the main group, a clear increase in physical activity by 19.6 points and 7.6 points in the main and control groups, respectively.Conclusions. Earlier relief of inflammatory symptoms of exacerbations of tonsillopharyngitis and restoration of patient well-being when a nonsteroidal anti-inflammatory drug was included in complex therapy confirmed its good efficacy and safety.
Insight of Saudi Users of Cosmetic Regarding Cosmetovigilance: A Survey of Knowledge, Attitude and Practice
Authors: Alosyli Fatimah , Aljebrin Lana , Alnowaiser Noura , Alodhilah Yara , Ibrahim Nada , Anaam Mohammed Saif , Farooqui Maryam , Alsahali Saud , Elghazaly Abir , Almogbel Yasser , Alsuhibani Ali 
Published: November 2024

Background
The term “Cosmetovigilance” was first introduced as a new term for addressing the safety of cosmetic products. There is still significant variability across the community regarding knowledge as well as legislation about cosmeceuticals.

Methods
An organized set of 38 questions addressing demographics, knowledge, practices, attitudes, and perceptions toward cosmetics along with additional 10 questions about reporting cosmetic adverse drug reactions were used to conduct a cross-sectional study. Using a convenience sample of 601 cosmetics consumers in Saudi Arabia, a Microsoft form was used to administer the questionnaire. The data analysis was performed using a statistical package for social science analysis (SPSS).

Results
The overall percentage of participants who answered the questions related to the knowledge was 89.6% (539/601). The association between knowledge score and demographic characteristics was explored. None of the demographic variables showed a significant association with knowledge (p > 0.05). Regarding attitudes, significant associations were found with age, marital status, income, and nationality (p < 0.001). Out of the 323 participants who completed the additional part of the questionnaire, 150 (46.4%) experienced cosmetic-related side effects, but only 1.3% reported the incidence of these effects. The occurrence of adverse effects connected to cosmetics is more common in women, younger age groups, and people who have ever experienced allergies (p < 0.001).

Conclusion
Our findings support the huge need for continued efforts to fully increase consumers' awareness of regulatory oversight and the importance of reporting adverse events to completely ensure the safety of cosmetic products in Saudi Arabia.
Editorial. Historia Económica Colonial
Authors: Torres James V. 
Published: November 2024

La revista tiempo&economía está próxima a cumplir diez años. Se trata de un acontecimiento notable para una publicación que, desde su incepción, hizo un llamado a traspasar las barreras disciplinares de la historia, la economía y la administración. Si se utiliza un término para evocar el tópico del presente dossier, la historia económica es una disciplina mestiza. Como en el periodo colonial, no es fácil encontrar un lugar para aquellos en un mundo concebido en dos repúblicas separadas. El costo de oportunidad para los economistas y administradores que se dedican al campo es muy alto, mientras que los historiadores han tendido a olvidar la realidad económica del pasado. A pesar de ello, la primera década de tiempo&economía muestra que la historia económica en el país preserva toda su vitalidad. No se trata, por cierto, de un fenómeno fortuito. El análisis económico de largo plazo es un laboratorio de las teorías forjadas en diversas ciencias sociales al tiempo que sirve para identificar aquellas persistencias del pasado que dificultan el desempeño económico del presente. De allí que instituciones como el Banco de la República hayan alentado investigaciones de largo aliento sobre el tema.
Simplified Medication Adherence Questionnaire (SMAQ) for People Living With HIV in a National Hospital in Mexico: Instrument Validation Study
Authors: Del Moral Trinidad Luis Eduardo , González Hernández Luz Alicia , Andrade Villanueva Jaime Federico , Martínez-Ayala Pedro , Valle Rodríguez Adriana , Ruíz Herrera Vida Veronica , Vizcaíno Résendiz José Adán , Herrera Godina Melva Guadalupe , Dominguez-Lara Sergio 
Published: November 2024

Background
Adherence to antiretroviral therapy is a critical component in achieving viral suppression in people living with HIV in addition to increasing overall quality of life. Several indirect methods have been used to measure adherence including the Simplified Medication Adherence Questionnaire (SMAQ).

Objective
The objective of this study is to evaluate the reliability and validity of the SMAQ in men living with HIV/AIDS attending a Mexican national hospital.

Methods
A cross-sectional analytical design study was carried out in a Mexican National Hospital in Jalisco, including men aged >18 years with at least 3 months of antiretroviral treatment, excluding those with cognitive difficulties in answering the survey. A minimum sample size was calculated to detect the contribution of the variables within the model. The analysis included descriptive tests, confirmatory factor analysis, reliability and validity assessment, correlation between adherence and viral load, and association between viral load and adherence.

Results
The final analysis included a total of 260 patients with a mean age of 43 (SD 12) years and an average of 8.97 (SD 6.33) years on antiretroviral treatment. The SMAQ showed sufficient structural validity (comparative fit index=1, root-mean-square error of approximation=0, 90% CI 0-0.085) with satisfactory factor loadings on most questions except item 2 (Do you always take your medication at the prescribed time?). The reliability of the scale is acceptable (Cronbach α=0.702, ω=0.718). Adherence correlated with viral load significantly but not with recent TCD4 lymphocyte levels. Patients classified as adherent were three times more likely to be undetectable than nonadherent patients (odds ratio 3.31, 95% CI 1.13-9.64, P=.04).

Conclusions
The SMAQ represents an adequate tool to assess adherence in men living with HIV in the Mexican context, this will contribute to this study and compression of adherence to establish future intervention programs.
The effect of titanium dioxide filler on soft liners on Candida albicans growth and surface hardness
Authors: Aditama Pramudya , Indrastuti Murti , Ruspita Intan 
Published: November 2024

Soft liners are recommended in denture stomatitis, yet they are prone to microorganism colonization. Modification of soft liners can be done by adding titanium dioxide (TiO2) because they induce photocatalytic production and increase the physical strength of the material. This research aims to examine the effect of adding (TiO2) filter in soft liners on the growth of Candida albicans and surface hardness. This research used disc-shaped soft liners with 2 sizes: 10 mm in diameter and 2 mm in thickness for the mold growth test and 10 mm in diameter and 6mm in thickness for surface hardness. Each of the 24 samples was divided into 4 groups: groups I, II, and III with the addition of (TiO2) at concentrations of 0.5%, 1%, and 2%, respectively, and group IV acting as the control group without (TiO2). Test of the growth of Candida albicans used dilution method, and calculations were made with a colony counter. Test of surface hardness used a durometer, and data were analyzed using one-way ANOVA and LSD. The results showed that among the groups, group III demonstrated the lowest growth of Candida albicans (7.67±2.25 x103CFU/mL), while group IV exhibited the highest growth (21.33±4.63 x103CFU/ml). The results of the ANOVA test showed that the addition of TiO2 had a significant effect on the growth of Candida albicans (p < 0.05). In the LSD test, there were significant differences between the control group and all of the treatment groups. In the surface hardness test, the highest was observed in group III (29.92 ± 1.52 HA), and the lowest was in group IV (23.08 ± 2.6 HA). The results of the ANOVA test indicated the effect of adding (TiO2) on the hardness of the soft liners (p < 0.05). The LSD test showed significant differences between the control group and all of the treatment groups. The addition of 0.5%-2% (TiO2) concentrations to soft liners inhibited the growth of Candida albicans, while the 0.5% concentration showed the smallest change in surface hardness.
Robustness, Exploitable Relations and History: Assessing Varitel Semantics as a Hybrid Theory of Representation
Authors: Sánchez Nicolás Sebastián 
Published: November 2024

A constitutive theory of representation must address two challenges. The content determination challenge requires specifying why a particular state has a given content. The job description challenge requires spelling out the explanatory role that representational notions play in that theory. Recently, Nicholas Shea has advanced varitel semantics as a hybrid approach to representation to answer those challenges, supplementing teleosemantics with non-historical features —namely, exploitable relations and robustness. In this paper, I critically assess the hybrid theory’s answers to both challenges, arguing that their hybrid nature undermines their merits. In each case, I will show that it is hard to establish how the alleged complementariness of the hybrid account components works. I will conclude that internal problems beset Shea’s theory of representation.
Mabel Alicia Campagnoli (coord.), Destellos de una biopolítica afirmativa. Andar y desandar las violencias contemporáneas
Authors: Rosenzweig Esteban 
Published: November 2024

Destellos de una biopolítica afirmativa, coordinado por Mabel Campagnoli, plantea una revisión completa sobre los alcances, las paradojas y los límites de la biopolítica actual. Su propuesta consiste en desandar las violencias contemporáneas.
Si con el término “bios”, la biopolítica ha expresado una oscilación semántica entre vida biológica y vida con existencia política, su reemplazo por “vio” como retoma Campagnoli, indica, en cambio, la proximidad entre lo viviente y su aparente inseparabilidad de una violencia constitutiva propia de la vida misma. Acuñando entonces, un nuevo término que destaque también una nueva semántica, la viopolítica pone en discusión el papel desempeñado por las violencias desarrolladas en las producciones de subjetividad y en las corporalidades dentro del capitalismo moderno-colonial del siglo XXI. ¿Hay alguna forma de que lo viviente no se encuentre sujeto y sometido a las tecnologías de dominación? ¿Se puede acaso, escapar a los modos de sujeción que se proponen canalizar y agotar la potencia vital de las formas de vida? Sin eludir los compromisos de tales formulaciones, el texto avanza, con diferentes perspectivas, en la proyección de una serie de respuestas desafiantes y consistentes. Se trata, en definitiva, de interrogar por la posibilidad de una biopolítica afirmativa. De una biopolítica donde los seres humanos puedan situarse más allá de su experiencia como sujetos y los seres vivos no humanos, excedan, asimismo, su condición exclusiva de recurso natural.
UM ESTUDO SEMÂNTICO-ARGUMENTATIVO NO GÊNERO ANÚNCIO PUBLICITÁRIO
Authors: Da Silva Adelino Francisca Janete , Gonçalves de Deus Kátia Regina , De Freitas Oliveira Araújo Rafaelle 
Published: November 2024

O presente artigo apresenta uma discussão sobre a construção da argumentação no gênero anúncio publicitário. O referido gênero textual é atualmente um dos meios mais utilizados por anunciantes, de maneira geral, que pretendem divulgar suas marcas e produtos a um público geral ou a um público mais específico, no intuito de atraí-lo a adquirir o objeto ofertado. Sabendo disso, este trabalho pretende investigar o fenômeno da modalização em anúncios publicitários criados por algumas grandes marcas, analisando quais são os efeitos de sentido gerados pelo uso dos modalizadores na construção dos argumentos na produção dos anúncios selecionados. O marco teórico aborda as noções de Semântica Argumentativa de Ducrot e colaboradores (1988); os conceitos da Modalização Discursiva defendidos por Cervoni (1989), Castilho e Castilho (2002), Moura Neves (2010), Koch (2009) e Nascimento e Silva (2012); e, por fim, o gênero anúncio é concebido com base na Teoria de Gêneros Discursivos, elaborada por Bakhtin (2000 [1979]). A metodologia adotada é bibliográfica e descritiva, de abordagem qualitativa. O corpus é formado por quatro anúncios disponíveis na rede mundial de computadores, que foram produzidos por grandes marcas que comercializam no Brasil. Os resultados revelaram que os modalizadores foram utilizados como recurso argumentativo presente nos textos de anúncios publicitários, como demonstrado, para além de reforçar as qualidades dos produtos, orientarem o consumidor para a compra.
Retos de la contratación pública local para garantizar la calidad y la innovación en los servicios de atención a las personas
Authors: Martí-Costa Marc , Conde López Cecilia Isabel 
Published: November 2024

Objetivos: la adecuación a la normativa y la garantía de la calidad del servicio son las principales preocupaciones de los responsables municipales encargados de las licitaciones de servicios de atención a las personas. Sin embargo, la combinación de ambos criterios requiere un importante esfuerzo de innovación pública. Este estudio tiene como objetivo identificar los desafíos a las Administraciones municipales, tanto endógenos como exógenos, en la redacción de pliegos de licitaciones. Metodología: se han analizado de los contratos licitados en estos servicios y se han realizado entrevistas a los equipos municipales responsables de la contratación y gestión en siete municipios de Catalunya (las capitales de provincia y tres de los municipios más poblados). Resultados: tanto los órganos de contratación como las entidades del tercer sector coinciden en la importancia de garantizar la calidad de estos servicios. Sin embargo, el marco normativo actual no permite priorizar a las entidades no lucrativas (excepto en el caso de la contratación reservada) ni considerar la proximidad geográfica de los licitadores, lo que limita la adecuación de la contratación a los servicios de atención a las personas. Conclusiones: se sugiere explorar otras opciones de gestión y contratación de estos servicios, tanto dentro como fuera del marco de la contratación pública.
Pengembangan Lembar Kerja Peserta Didik Berbasis Game Tradisional Congklak Menggunakan Metode Peer Tutoring
Authors: Setyowardany Donna Pratiwi , Murtafiah Wasilatul , Susanti Vera Dewi 
Published: November 2024

Abstract
This study aims to development of teaching materials for learning mathematics in the field of LKPD. LKPD based on the traditional game congklak which uses the peer tutor method and is integrated with cultural elements is developed to support the learning process, increase students' motivation in learning activities, and introduce traditional game. The type of research used is development with the 4D research method (Define, Design, Development, Disseminate). This research was conducted at SMPN 1 Jiwan with research subjects of seventh grade students. The data collection techniques used were interviews, documentation, questionnaires, and tests. The instruments used were product validation sheets, student response questionnaire validation sheets, questionnaire validation questions, student response questionnaire sheets, and test questions. Based on the data obtained, it shows that the LKPD based on traditional congklak game using the peer tutor method meets the criteria of valid, practical, and effective so that it is feasible to use as teaching material in the mathematics learning processes that serve to increase student learning motivation.

Keywords: LKPD, Games, Congklak, Peer Tutoring, Teaching Materials

Abstrak
Penelitian ini memiliki tujuan guna mengembangkan bahan ajar pembelajaran matematika berupa LKPD. LKPD berbasis permainan tradisional congklak, yang menggunakan metode peer tutoring dan dipadukan dengan unsur budaya, dikembangkan untuk mendukung proses pembelajaran, meningkatkan motivasi peserta didik dalam pembelajaran, serta memperkenalkan permainan tradisional. Jenis penelitian yang digunakan adalah piengiembangan diengan mietodie pienielitian 4D (Diefinie, Diesign, Dievielopmient, Dissieminatie). Pienielitian ini dilakukan di SMPN 1 Jiwan diengan subjiek penelitian adalah piesierta didik kielas VII. Tieknik piengumpulan data yang digunakan yaitu wawancara, dokumientasi, angkiet, dan ties. Instrumien yang digunakan adalah liembar validasi produk, liembar validasi angkiet riespon piesierta didik, angkiet validasi soal, liembar angkiet riespon piesierta didik, dan soal ties. Bierdasarkan data yang didapat mienunjukkan bahwa LKPD bierbasis gamie tradisional congklak mienggunakan mietodie pieier tutoring miemienuhi kritieria valid, praktis, dan iefiektif siehingga layak digunakan siebagai bahan ajar dalam pembelajaran matematika yang berfungsi meningkatkan motivasi belajar peserta didik.

Kata Kunci: LKPD, Game, Congklak, Peer Tutoring, Bahan Ajar
PEMBANGUNAN TATA RUANG DI INDONESIA: TANTANGAN DAN HARAPAN
Authors: Farida Ida 
Published: November 2024

Implementasi pembangunan tata ruang di beberapa daerah di seluruh Indonesia masih belum optimal dikarenakan berbagai permasalahan yang muncul sehingga diperlukan solusi untuk mengatasinya. Penelitian ini mengeksplorasi tantangan dan harapan utama yang dihadapi dalam proses pembangunan tata ruang di Indonesia. Untuk menggali lebih dalam mengenai tantangan dan harapan dalam proses pembangunan tata ruang di Indonesia maka penelitian ini menggunakan metodologi kualitatif dengan jenis penelitian hukum normative. Pengumpulan data menggunakan data sekunder berupa dokumen-dokumen yang mengikat (primer) dan dokumen-dokumen tambahan lainnya yang berasal dari hasil penelitian sebelumnya. Data-data tersebut dianalisis secara deskriptif untuk menguraikan informasi rinci yang ada pada dokumen-dokumen sekunder yang telah dikumpulkan. Hasil kajian menunjukkan bahwa ada beberapa faktor yang menghambat proses pembangunan tata ruang di Indonesia, diantaranya, kebijakan yang ambigu, konflik kepentingan antara sektor-sektor terkait, keterbatasan sumber daya, serta kurangnya koordinasi antara pemerintah pusat dan daerah menjadi fokus utama dalam penelitian ini. Hasil penelitian ini diharapkan dapat memberikan wawasan yang mendalam tentang tantangan yang dihadapi dalam upaya pembangunan tata ruang di Indonesia serta memberikan rekomendasi bagi penyusunan kebijakan yang lebih efektif dan implementasi yang lebih baik. Implikasi hukum dan kontribusi terhadap proses pengambilan keputusan tata ruang menjadi bagian integral dari penelitian ini.