bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating fatty acids, genetic susceptibility and hypertension: a prospective cohort study
Authors: Lu Lingling , Gu Xiaoli , Yang Daheng , Wang Bingjian , Long Guangfeng 
Published: October 2024

BackgroundCombining genetic risk factors and plasma fatty acids (FAs) can be used as an effective method of precision medicine to prevent hypertension risk.MethodsA total of 195,250 participants in the UK Biobank cohort were included in this study from 2006–2010. Polygenic risk scores (PRSs) were calculated for hypertension using single-nucleotide polymorphisms (SNPs). Concentrations of plasma FAs, including polyunsaturated fatty acids (PUFAs), monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs), were tested by nuclear magnetic resonance. The Cox model was used to test for the main effects of PRS, different plasma FAs and their joint effects on hypertension. Relative excess risk due to interaction (RERI) and the attributable proportion due to interaction (AP) were used to test the additive interaction.ResultsPlasma PUFAs, n-3 PUFAs, MUFAs and SFAs were related to the risk of hypertension (PUFAs: HR, 0.878; 95% CI, 0.868–0.888; MUFAs: HR, 1.13; 95% CI, 1.123–1.150; SFAs: HR, 1.086; 95% CI, 1.074–1.098; n-3 PUFAs: HR, 0.984; 95% CI, 0.973–0.995). Moreover, an additive interaction was found between PRS and plasma FAs, which could contribute to an approximately 10–18% risk of hypertension, and the associations between high plasma MUFAs and a high PRS of hypertension were the strongest positive [RERI: 0.178 (95% CI: 0.062, 0.294), AP: 0.079 (95% CI: 0.027, 0.130)].ConclusionIncreased plasma MUFAs or SFAs and decreased plasma PUFAs or n-3 PUFAs were associated with hypertension risk, especially among people at high genetic risk.
Retroperitoneal bronchogenic cyst: a case report and literature review
Authors: Jiang Bohao , Xie Tiantian , Hu Jiyuan , Xu Yitong , Zhang Hao 
Published: October 2024

IntroductionRetroperitoneal bronchogenic cyst, typically situated in the subdiaphragmatic region, is a rare congenital benign developmental abnormality arising from dysplasia of the foregut and abnormal budding of the tracheobronchial tree. Due to its low incidence, there are limited reports regarding this condition.Case presentationFour retroperitoneal bronchogenic cysts near the left adrenal gland were identified without accompanying clinical symptoms. One case was misdiagnosed as an adrenal tumor prior to surgery, while the others were diagnosed as retroperitoneal cysts of uncertain origin. All cases underwent surgical resection, with three being performed laparoscopically and one utilizing robot-assisted techniques. Pathological reports confirmed the diagnosis of bronchogenic cyst in each instance. The prognosis was favorable for all four patients, with no complications or recurrences observed. Additionally, a literature review was conducted, encompassing 82 cases, which revealed similar characteristics and radiological manifestations in the majority of cases.ConclusionAlthough retroperitoneal bronchogenic cysts are rare developmental malformations lacking distinctive clinical and radiological features, reported cases exhibit similarities in certain clinical and imaging characteristics. This report offers additional insights into the diagnosis and management of this rare disease. Future reports are essential to enhance understanding of this disease.
Association between moderate-to-vigorous physical activity and attention among children aged 6–12 years: chain mediating effects of fundamental movement skills and aerobic fitness
Authors: Wu Haitan , Wang Xidong , Jin Zhangyi 
Published: October 2024

PurposeTo explore the association between physical activity and attention among children aged 6–12 years and to determine whether fundamental movement skills and aerobic fitness mediate the association between physical activity and attention.MethodsA total of 1,086 school-aged children (mean age: 9.40 ± 2.03 years) were included in the present study. Physical activity was assessed using the International Physical Activity Scale-Short Form. Fundamental movement skills were assessed using the Test of Gross Motor Development, third edition, and aerobic fitness was evaluated using the 20-metre shuttle run. Attention was assessed by the d2 Attention Test.ResultsThere were significant positive correlations between physical activity and fundamental movement skills, physical activity and aerobic fitness, and physical activity and attention (all p &lt; 0.05). Both fundamental movement skills and aerobic fitness fully mediated the relationship between physical activity and attention. In addition, fundamental movement skills and aerobic fitness had chain-mediating effects on the relationship between physical activity and attention.ConclusionHigh levels of physical activity were positively associated with attention among school-aged children. Fundamental movement skills and aerobic fitness played a chain-mediating role in the relationship between physical activity and attention.
Littoral cell angioma of a huge spleen with peripheral blood pancytopenia in a 14-year-old boy: a case report and review of the literature
Authors: Gao Tianyu , Wang Xingang , Wei Qiuya , Wang Chen , Fan Yong , Wang Yuebin 
Published: October 2024

BackgroundSplenic littoral cell angioma (LCA) is an exceptionally uncommon malignant potential vascular tumor with infrequent occurrences in pediatric patients. Due to its reliance on histopathological analysis for diagnosis, LCA may be mistakenly identified as other splenic tumors. Patients with LCA may experience anemia or thrombocytopenia, but peripheral blood pancytopenia is infrequent.Case reportA 14-year-old boy presented with peripheral blood pancytopenia, necessitating hospitalization after splenomegaly was identified during a physical examination. Following the exclusion of hematological disorders, a splenectomy was conducted; histopathological examination confirmed the diagnoses of LCA. No metastases or recurrences were observed during the 8-month follow-up. To the best of our knowledge, this case represents the first instance of LCA associated with pancytopenia in a pediatric patient.ConclusionLCA can lead to iron-deficiency anemia or thrombocytopenia, with rare occurrences of pancytopenia, potentially resulting in misdiagnosis as a hematological disorder. Surgical intervention remains an effective treatment for LCA.
Effects of short video addiction on college students’ physical activity: the chain mediating role of self-efficacy and procrastination
Authors: Zhao Zhe , Kou Yali 
Published: October 2024

IntroductionExcessive use of short video applications can adversely affect the physical and mental health of college students. At present, regarding the effect of short video addiction on physical exercise, few scholars have studied the mechanism of action. This study aims to investigate the mechanism by which short video addiction impacts college students’ physical exercise. Therefore, we investigated the correlation between short video addiction and physical activity, and examined the influence of self-efficacy and procrastination on this relationship.MethodsIn this research, 304 college students were selected as survey subjects. The questionnaires included Short Video Addiction Scale, Physical Activity Rating Scale, General Self-Efficacy Scale, and Short Version General Procrastination Scale. The data underwent correlation analysis using SPSS and mediation effect analysis using the PROCESS macro program.Results(1) 61.51% (187) of college students’ physical activity was low exercise. (2) Physical activity was significantly negatively impacted by short video addiction. (3) Self-efficacy played an independent mediating role in the association between short video addiction and physical activity. (4) The association between short video addiction and physical activity was independently mediated by procrastination. (5) Self-efficacy and procrastination function as chain mediators in the association between short video addiction and physical activity.DiscussionOur research identifies the role that self-efficacy and procrastination play in the connection between short video addiction and physical activity. Decreasing the utilization of short video applications and enhancing self-efficacy can reduce procrastination and improve physical activity for college student groups.
Implementing a stabilizing intervention for traumatized refugees in temporary accommodations in South-West Germany - a randomized controlled pilot trial
Authors: Rzepka Irja , Zehetmair Catharina , Nagy Ede , Friederich Hans-Christoph , Nikendei Christoph 
Published: October 2024

The prevalence of trauma-related disorders, such as post-traumatic stress disorder (PTSD), as well as depressive or anxiety disorders, are significantly increased in refugees compared to the general population. This is due to the high risk of burdening and potentially traumatic experiences before, during and after their flight. However, the treatment options for these mental illnesses are significantly limited due to the legal uncertainties surrounding the asylum procedure as well as language and cultural barriers. In this study, a randomized controlled pilot trial was conducted to assess the effectiveness of self-applied audio-based mindfulness and guided imagery techniques for refugees with symptoms of post-traumatic stress disorder living in temporary accommodations. The symptom burden of PTSD, depression, and anxiety symptoms, as well as perceived stress and emotional state was assessed using the PC-PTSD-5, PHQ-4, Self-Assessment Manikin, and Stress Thermometer. N=32 refugees were included in the intervention study, n=24 participants completed the study. The audio-based mindfulness and guided imagery techniques were presented to n =17 refugees in the intervention group between T1 and T2 over 4 weeks; n=15 refugees from the waiting list control group received the audio-files 6 weeks after follow-up. Efficacy was evaluated using a mixed analysis of variance. There were no significant changes in the symptoms of post-traumatic stress disorder, depression and anxiety disorder. Moreover, no changes were observed in the level of perceived stress or emotional state. Only few participants used the exercises in self-administered application during the study period. This was mainly due to the stressors of the post-migratory phase, such as job search or worries about residence status. Due to the self-administered nature of the intervention, common factors, such as therapeutic alliance or expectations regarding the intervention’s effectiveness, had minimal influence and did not contribute to the sustained use of the exercises. Additionally, regarding the life circumstances of refugees in temporary shelters, the intervention intensity may not have been sufficient to have a significant impact on the examined symptom burden. Small sample size and limited use of the exercises limit the reliability of the results.Clinical trial registrationhttps://drks.de/search/de/trial/DRKS00022862 Deutsches Register Klinischer Studien identifier, DRKS00022862.
Oral health knowledge, attitudes, and practices among female public health and nutrition university students in Qatar
Authors: Elwadia Amal , Naeem Aisha , Veettil Shajitha Thekke , Orquia Nikki , Alsayed Hassan Diana , Amuna Paul , Daud Alaa 
Published: October 2024

ObjectivesThe present study aimed to determine oral health (OH) related knowledge, attitudes, and practices among Public Health (PH) and Nutrition (NU) students at Qatar University.MethodA cross-sectional study was conducted using a pre-validated questionnaire comprising 36 items covering demographics, knowledge, attitudes and perception of oral health practices. Data were analyzed descriptively (means, standard deviations, proportions) and inferentially using statistical tests including t-tests for comparing means, and chi-square tests for examining associations between categorical variables.ResultsA total of 112 female undergraduate students participated, including 41 from PH and 71 from NU programs (response rate for both courses = 59.5%). The mean age was 21.8, while 23% were Qataris and 77% non-Qataris. Overall, students demonstrated good knowledge of OH (67.65%), with the PH group scoring higher (70.7%) than NU (65.35%). Knowledge regarding dental plaque was low for both groups (31.0%). Attitudes toward OH varied among participants. Most students reported practicing brushing with fluoridated toothpaste and demonstrated high knowledge regarding the association between poor OH and general health (95%).ConclusionOverall, PH and NU undergraduate students exhibited relatively good knowledge of OH, however, demonstrated a range of attitudes and practices, including suboptimal ones. Integration of OH education into the PH and NU curriculum is warranted, along with enhanced interprofessional education to promote self-awareness and improve patient oral health outcomes.
Isolation, Antibacterial Activity and Molecular Identification of Avocado Rhizosphere Actinobacteria as Potential Biocontrol Agents of Xanthomonas sp.
Authors: Trinidad-Cruz Jesús Rafael , Rincón-Enríquez Gabriel , Evangelista-Martínez Zahaed , López-Pérez Luis , Quiñones-Aguilar Evangelina Esmeralda 
Published: October 2024

Actinobacteria, especially the genus Streptomyces, have been shown to be potential biocontrol agents for phytopathogenic bacteria. Bacteria spot disease caused by Xanthomonas spp. may severely affect chili pepper (Capsicum annuum) crops with a subsequent decrease in productivity. Therefore, the objective of the study was to isolate rhizospheric actinobacteria from soil samples treated by physical methods and evaluate the inhibitory activity of the isolates over Xanthomonas. Initially, soil samples collected from avocado tree orchards were treated by dry heat air and microwave irradiation; thereafter, isolation was implemented. Then, antibacterial activity (AA) of isolates was evaluated by the double-layer agar method. Furthermore, the positive/negative effect on AA for selected isolates was evaluated on three culture media (potato-dextrose agar, PDA; yeast malt extract agar, YME; and oat agar, OA). Isolates were identified by 16S rRNA sequence analysis. A total of 198 isolates were obtained; 76 (series BVEZ) correspond to samples treated by dry heat and 122 strains (series BVEZMW) were isolated from samples irradiated with microwaves. A total of 19 dry heat and 25 microwave-irradiated isolates showed AA with inhibition zones (IZ, diameter in mm) ranging from 12.7 to 82.3 mm and from 11.4 to 55.4 mm, respectively. An increment for the AA was registered for isolates cultured on PDA and YME, with an IZ from 21.1 to 80.2 mm and 14.1 to 69.6 mm, respectively. A lower AA was detected when isolates were cultured on OA media (15.0 to 38.1 mm). Based on the 16S rRNA gene sequencing analysis, the actinobacteria belong to the Streptomyces (6) and Amycolatopsis (2) genera. Therefore, the study showed that microwave irradiation is a suitable method to increase the isolation of soil bacteria with AA against Xanthomonas sp. In addition, Streptomyces sp. BVEZ 50 was the isolate with the highest IZ (80.2 mm).
New Epitopes for the Serodiagnosis of Human Borreliosis
Authors: Alcón-Chino Mônica E. T. , Bonoldi Virgínia L. N. , Pereira Rosa M. R. , Gazeta Gilberto S. , Carvalho João P. R. S. , Napoleão-Pêgo Paloma , Durans Andressa M. , Souza André L. A. , De-Simone Salvatore G. 
Published: October 2024

Lyme disease, a zoonotic infection caused by the bacterium Borrelia burgdorferi, is transmitted to humans through the bites of infected ticks. Its diagnosis primarily relies on serological methods; however, the existing borreliosis techniques have shown a variable sensitivity and specificity. Our study aimed to map IgG epitopes from five outer membrane proteins (Omp) from B. burgdorferi [Filament flagellar 41kD (PI1089), flagellar hook-associated protein (Q44767), Flagellar hook k2 protein (O51173), Putative Omp BURGA03 (Q44849), and 31 kDa OspA (P0CL66)] lipoprotein to find specific epitopes for the development of accurate diagnosis methods. Using the spot synthesis technique, a library of 380 peptides was constructed to identify linear B cell epitopes recognized by human IgG in response to specific B. burgdorferi-associated proteins. The reactivity of this epitope when chemically synthesized was then evaluated using ELISA with a panel of the patient’s sera. Cross-reactivity was assessed through data bank access and in vitro analysis. Among the 19 epitopes identified, four were selected for further investigation based on their signal intensity, secondary structure, and peptide matching. Validation was performed using ELISA, and ROC curve analysis demonstrated a sensitivity of ≥85.71%, specificity of ≥92.31, accuracy of ≥90.7, and AUC value of ≥0.91 for all peptides. Our cross-reactivity analysis demonstrated that the Burg/02/huG, Burg/03/huG, and Burg/12/huG peptides were not reactive to antibodies from patients with Leptospirosis and syphilis compared to those from the B. burgdorferi group. These peptides indicated an excellent performance in distinguishing between B. burgdorferi-infected and non-infected individuals and exhibited a neglected reactivity to antibodies in sera from patients with Leptospirosis and syphilis. These peptides are promising targets for recombinant development, potentially leading to more accurate serological tests and vaccines.
шЫҒЫС қАЗАҚСТАН ОБЛЫСЫ сЕМЕЙ ҚАЛАСЫНДА ЯДРОЛЫҚ ТЕХНОЛОГИЯҒА НЕГІЗДЕЛГЕН МЕДИЦИНАЛЫҚ РАДИОЛОГИЯЛЫҚ КЛАСТЕР ҚҰРУДЫҢ НЕГІЗГІ АЛҒЫ ШАРТТАРЫ
Authors: М.Н. Сандыбаев , Т.А. Әділханов 
Published: October 2024

Кіріспе. Медицина ғылымының қазіргі жағдайы, сондай-ақ денсаулық сақтау ісін реформалау үрдістері өңірде заманауи ғылымды керек ететін технологияның қажеттігі туралы айтуға мүмкіндік беріп отыр. Ядролық медицинаның ерекшелігі ғылым мен техниканың әртүрлі саласында ауқымы кең ресурстарды тарту болып табылады, бұл өз кезегінде Қазақстанда аталмыш саланың дамуы бойынша күрделі кешенді ведомствоаралық жолды талап етеді. Мақсат - Шығыс Қазақстан облысы (ШҚО) Семей қаласында ядролық технологияға негізделген медициналық радиологиялық кластер құрудың заманауи жағдайын ұсыну. Қорытынды. Семей қаласында құрылатын, радионуклидті технология пайдаланылатын, ядролық медицина орталығы радиофармпрепараттарға, радиоизотоп генераторларға қажеттілікті қамтамасыз ететін ғылыми, өндірістік және кадрлық әлеуетті алдын ала құруға және Қазақстан өңірлерінде жаппай диагностикалық зерттеулерді орындауға мүмкіндік береді.
Introduction.The current situation in medical science and the processes of health reform allow us to speak about the necessity of implementation of modern high technologies in the region. The peculiarity of nuclear medicine is to attract resources from the various areas of science and technology, which, in turn, requires a serious comprehensive interagency approach for the development of this industry in Kazakhstan. The purpose is to present the current conditions for the establishment of medical radiological cluster in Semey city of East Kazakhstan region, which is based on nuclear technology. Conclusion. The nuclear medicine center in Semey city, that uses the radionuclide technology will advance to create a scientific, industrial and staff capacity that will ensure the needs for radiopharmaceuticals, radionuclide generators, and perform numerous diagnostic tests in the regions of Kazakhstan.
Введение. Современное состояние медицинской науки, а так же процессы реформирования здравоохранения позволяют говорить о необходимости внедрения современных наукоемких технологий в регионе. Особенностью ядерной медицины является привлечение ресурсов из обширного спектра различных областей науки и техники, что, в свою очередь, требует серьезного комплексного межведомственного подхода по развитию данной отрасли в Казахстане. Цель - представить современные условия создания медицинского радиологического кластера, основанного на ядерных технологиях, в г. Семей Восточно-Казахстанской области. Вывод. Создаваемый в г. Семей центр ядерной медицины, использующий радионуклидные технологии позволит заблаговременно создать научный, производственный и кадровый потенциал, который будет обеспечивать потребность в радиофармпрепаратах, генераторах радиоизотопов и выполнять массовые диагностические исследования в регионах Казахстана.
ПСИХОЛОГИЧЕСКОЕ СОСТОЯНИЕ И ПРОФЕССИОНАЛЬНОЕ ВЫГОРАНИЕ У ПЕДАГОГОВ СЕВЕРНОГО УНИВЕРСИТЕТА, ПЕРЕНЕСШИХ COVID-19
Authors: М.А. Попова , А.Э. Щербакова , В.В. Чистова 
Published: October 2024

В статье приведены данные по изменению психологического состояния и профессионального выгорания у педагогов северного университета после COVID-19. Обследованы 52 педагога (32 мужчины, 20 женщин) до пандемии и через 8-14 недель после COVID-19 по методикам ТФАР и MВI. Статистический анализ проведён с помощью программы "Statistica13.3" с применением критериев Манна-Уитни (U), χ2 и Вилкоксона (W). После COVID-19 у педагогов выявлено повышение уровня тревожности с 65,4 до 76,9%, фрустрированности - с 23,1 до 50,0%, ригидности - с 53,8 до 69,2%, тенденция к снижению агрессивности - с 38,5 до 34,6%. Частота профессионального выгорания увеличилась после СOVID-19 с 30,8 до 69,2%, эмоционального истощения - с 73,1 до 80,8%, деперсонализация сохранилась на уровне 57,7%. Редукция личных достижений в постковидном периоде выявлена в 30,8%.
The article presents data on changes in the psychological state and professional burnout among teachers of the Northern University after COVID-19.52 teachers (32 men, 20 women) were examined before the pandemic and 8-14 weeks after COVID-19 according to the methods of TFAR and MVI. Statistical analysis was carried out using the program "Statistica13.3" using the Mann-Whitney (U), χ2 and Wilcoxon (W) criteria. After COVID-19, teachers revealed an increase in the level of anxiety from 65.4 to 76.9%, frustration 23.1 to 50.0%, rigidity 53.8 to 69.2%, a tendency to decrease aggressiveness from 38.5 to 34.6%. The frequency of professional burnout increased after COVID-19 from 30.8 to 69.2%, emotional exhaustion from 73.1 to 80.8%, depersonalization remained at 57.7%. Reduction of personal achievements in the postcovid period was revealed in 30.8%.
ТРАНСГРЕССИЯ ЯЗЫКОВОЙ ЛИЧНОСТИ: МНОГОАСПЕКТНОСТЬ ЯВЛЕНИЯ
Authors: М.М. Бетильмерзаева 
Published: October 2024

В статье предложен философский анализ трансгрессии языковой личности. Цель исследования в выяснении многоаспектности феномена "трансгрессия" и в определении его места и роли в контексте обнаружения границ между тем, что есть и может быть, что позволяет продуцировать новые смыслы языка. Для достижения указанной цели автором сформулированы следующие задачи: выяснить содержание понятия «трансгрессия» в современном философско-культурологическом дискурсе; раскрыть потенциал трансгрессивных процессов в формировании новых смыслов как вещей, так и явлений в развитии языковой личности.
The article proposes a philosophical analysis of the transgression of a linguistic personality. The purpose of the study is to clarify the multidimensionality of the phenomenon of "transgression" and to determine its place and role in the context of discovering the boundaries between what is and what can be, which allows producing new meanings of the language. To achieve this goal, the author formulated the following tasks: to clarify the content of the concept of "transgression" in modern philosophical and cultural discourse; to reveal the potential of transgressive processes in the formation of new meanings of both things and phenomena in the development of a linguistic personality.