bluuebunny/crossref_metadata_2025_split huggingface dataset:
Спектральный анализ органических компонентов деминерализованных костных биоимплантатов-=SUP=-*-=/SUP=-
Authors: Тимченко П.Е. , Тимченко Е.В. , Волова Л.Т. , Фролов О.О. 
Published: May 2019

AbstractThe results of an advanced spectral analysis of human donor bone grafts obtained using Raman spectroscopy are presented. Mathematical methods were applied to improve the resolution of spectral profiles, and chemometric principal component analysis was used to evaluate the organic components of the grafts. The results were compared to the proteomic data obtained using mass spectrometry. The main differences between cadaver and intraoperative grafts were observed in the Raman spectral lines at 1450 and 1735 cm^–1 (lipids and fatty acids), 917 and 937 cm^–1 (glycogen), and 814 and 894 cm^–1 (DNA), as well as 1238 and 1560 cm^–1 (amide II and amide III). It is shown that Raman spectroscopy can be employed to evaluate relative concentrations of components of DNA, RNA, collagen, protein, extracellular matrix, and bone tissue.
PEMANFAATAN SISTEM INFORMASI GEOGRAFIS UNTUK ARAHAN PENGGUNAAN LAHAN DI DAS PERCUT, SUMATERA UTARA
Authors: Rahmad Riki , Sormin Adelina 
Published: May 2019

Tujuan penelitian ini adalah untuk mengetahui arahan penggunaan lahan di Daerah Aliran Sungai Percut dengan memanfaatkan Sistem Informasi Geografis. Populasi dalam penelitian ini adalah seluruh daerah Sub DAS Percut. Teknik pengambilan sampel yang digunakan adalah total sampling, yaitu populasi sekaligus dijadikan sampel. Teknik analisis data yang digunakan dalam penelitian ini adalah teknik analisis kualitatif dengan pengharkatan (scoring) pada parameter penelitian berupa overlay/ tumpang susun peta. Overlay peta merupakan teknik analisis dalam SIG untuk mengetahui dan melakukan analisis keruangan yang dilakukan dengan cara tumpang susun antara beberapa peta dengan berbeda, yang menggunakan perangkat lunak ArcGIS. Hasil penelitian menunjukkan bahwa arahan penggunaan lahan di DAS Percut terdiri dari 3 kawasan, yaitu Kawasan Lindung dengan luas 4.258,19 Ha atau 9,9% dari keseluruhan daerah penelitian. Kawasan penyangga yaitu dengan luas 9.250 Ha atau (21,7%) dan Kawasan Budidaya tanaman semusim dan permukiman yaitu dengan luas 29.250 Ha atau 68,4%.
PENGEMBANGAN AIR TERJUN SIKULIKAP DESA DOULU SEBAGAI OBJEK WISATA ANDALAN MASYARAKAT KABUPATEN KARO
Authors: Purba Josephine Adelways 
Published: May 2019

Kawasan wisata Air Terjun Sikulikap di Desa Doulu merupakan sebuah wisata barunya Sumatera Utara yang dalam tahap perintisan dan pengembangan. Sehingga banyak peluang untuk melakukan penelitian maupun dijadikan sebuah lokasi untuk kegiatan penelitian. Banyaknya potensi yang melimpah dari hasil alamnya, perikanannya, berbagai macam makanan khas dari Tanah Karo, dan masyarakat yang ramah serta mudah untuk diajak kerjasama. Tujuan penelitian ini untuk mengetahui Potensi wisata dan persepsi pengunjung tentang Sapta Air Terjun Sikulikap Di Desa Doulu, Kecamatan Berastagi Kabupaten Karo. Metode penelitian ini dianalisis dengan deskriftif kualitatif yaitu dengan menampilkan data dalam bentuk tabel-tabel frekuensi mengenai persepsi masyarakat mengenai objek wisata Air Terjun Sikulikap. Dengan adanya panorama alam yang indah dan suasana objek wisata yang memberikan kenyamanan yang dimiliki oleh objek wisata Air Terjun Sikulikap maka pengunjung tidak akan bosan dalam berkunjung. Sehingga tidak terpengaruh dengan munculnya objek wisata baru serta persaingan antar objek wisata. Maka pemerintah harus meningkatkan sarana dan prasarana serta infrastruktur yang menunjang dan peningkatan fasilitas-fasilitas penunjang lainnya sehingga menarik dan memberi kenyamanan bagi pengunjung.
ANALISIS TINGKAT KESEJAHTERAAN KELUARGA NELAYAN PERAHU MESIN TEMPEL DI KELURAHAN BELAWAN BAHAGIA KECAMATAN BELAWAN KOTA MEDAN
Authors: Hutabarat Nuraini , Lumbantoruan Walbiden 
Published: May 2019

Penelitian ini bertujuan untuk mengetahui (1) Pendapatan keluarga nelayan perahu mesin tempel di kelurahan Belawan Bahagia Kecamatan Belawan Kota Medan, (2) Tingkat kesejahteraan keluarga nelayan perahu mesin tempel di Kelurahan Belawan Bahagia Kecamatan Belawan Kota Medan. Penelitian ini dilakukan di Kelurahan Belawan Bahagia Kecamatan Belawan Kota Medan tahun 2018. Populasi dalam penelitian ini adalah seluruh Nelayan Perahu Mesin Tempel di Kelurahan Belawan Bahagia yang berjumlah 33 kepala keluarga. Sampel dalam penelitian ini menggunakan Total Sampling. Teknik pengumpulan data yang digunakan adalah teknik komunikasi langsung dan teknik studi dokumenter. Teknik analisis data yang digunakan adalah teknik analisis deskriptif kualitatif. Hasil penelitian menunjukkan bahwa: (1) Tingkat pendapatan keluarga nelayan perahu mesin tempel di Kelurahan Belawan Bahagia 16 (48,49%) keluarga tergolong dalam kategori sedang, 9 (27,27%) keluarga tergolong dalam kategori tinggi, dan 8 (24,24%) keluarga yang tergolong dalam kategori rendah. Bila dikaitkan dengan UMR kota Medan 2018 (Rp.2.132.188) maka pendapatan keluaraga nelayan perahu mesin tempel seluruhnya berada di atas UMR kota Medan. (2) Tingkat kesejahteraan keluarga nelayan perahu mesin tempel di kelurahan Belawan Bahagia 8 (24,24%) keluarga tergolong Keluarga Pra Sejahtera, 19 (57,58%) keluarga tergolong Keluarga Sejahtera I, 3 (9,09%) keluarga tergolong Keluarga Sejahtera II, 2 (6,06%) keluarga tergolong Keluarga Sejahtera III, dan 1 (3,03%) keluarga tergolong Keluarga Sejahtera III+. Hal ini menunjukkan bahwa tingkat pendapatan mempengaruhi tingkat kesejahteraan keluarga, yang mana semakin tinggi pendapatan keluarga, semakin tinggi pula tingkat kesejahateran keluarga tersebut. Kata kunci: Nelayan, Kesejahteraan, Pendapatan
Perforacja jelit jako powikłanie chemioterapii ostrej białaczki limfoblastycznej u dzieci – opis dwóch przypadków
Authors: Kaleta Marcelina , Zawitkowska Joanna , Kowalczyk Jerzy R. , Olcha Tomasz 
Published: May 2019

AbstractWielolekowa chemioterapia stanowi podstawę współczesnych metod leczenia nowotworów układu krwiotwórczego u dzieci. Stosując poszczególne grupy leków, należy mieć na uwadze ewentualne ich skutki uboczne, m.in. zaburzenia gastroenterologiczne. Prezentujemy przypadki kliniczne dwóch pacjentów z ostrą białaczką limfoblastyczną, leczonych w Klinice Hematologii, Onkologii i Transplantologii Dziecięcej w Lublinie, u których powikłaniem chemioterapii była perforacja jelit. W obydwu przypadkach w trakcie leczenia indukcyjnego wystąpiły silne bóle brzucha. W badaniu fizykalnym stwierdzono wzdęcie brzucha, brak perystaltyki, wypuk bębenkowy, a w wykonanym zdjęciu radiologicznym jamy brzusznej cechy niedrożności oraz perforacji jelit. W trybie pilnym wykonano zabieg chirurgiczny. Zarówno operacja, jak i czas rekonwalescencji były przyczyną długich przerw w chemioterapii, co mogło wpływać na rokowanie. Dotychczas nie zostały opracowane algorytmy dotyczące postępowania w przypadku perforacji u pediatrycznych pacjentów onkologicznych. Szeroko rozumiana profilaktyka stanowi niekwestionowaną rolę w zapobieganiu działaniom niepożądanym leków.
Main problems in natural seed regeneration of pedunculate oak (Quercus robur L.) stands in Ukraine
Authors: Rumiantsev Maksym , Lukyanets Volodymyr , Musienko Sergiy , Mostepanyuk Andriy , Obolonyk Iryna 
Published: May 2019

Abstract
The literature review article sums up research experiences in natural seed regeneration in oak forests. In the past, the natural habitat for pedunculate oak (Quercus robur L.) was considerably wider than now. The downward trend in the area of oak stands is observed both in Ukraine and other European countries. In Ukraine, the area of natural oak stands of seed origin is decreasing by 2.0 thousand hectares each year. The most significant environmental factor in the emergence and normal growth of young oaks of seed origin is the light amount, which should reach at least 20% of the full sunlight. In addition to the light, the main factors contributing to the emergence of oak seedlings under forest canopies and in cutting areas are the oak fruiting and the litter and soil moisture. On the contrary, the excessive development of forest live cover with sedge and cereal vegetation, root competition from the parent trees, and a dense undergrowth were the hindering factors. In the forests of Ukraine, the largest number of natural seed reproduction of oak (more than 100 thousand stems ha−1) after the harvest year was recorded under the canopy of mature and overmature oak forests with a stocking of 0.6–0.7 and with 70 oaks in the stand species composition, growing in conditions of fresh and moist oak forests of Polissya and Forest-Steppe zones. Scientific and methodical guidelines for using natural reproduction of valuable species during the natural seed regeneration of oak stands were improved.
A new instrument for predicting survival of patients with cerebral metastases from breast cancer developed in a homogeneously treated cohort
Authors: Janssen Stefan , Hansen Heinke C , Dziggel Liesa , Schild Steven E , Rades Dirk 
Published: May 2019

Abstract

Background
Previous survival scores for breast cancer patients with cerebral metastases were developed in cohorts receiving heterogeneous treatments, which could have introduced selection biases. A new instrument (WBRT-30-BC) was created from 170 patients receiving whole-brain radiotherapy (WBRT) alone with 30 Gy in 10 fractions.

Methods
Characteristics showing significant associations (p < 0.05) with overall survival (OS) or a trend (p < 0.08) on multivariate analysis were used for the WBRT-30-BC. For each characteristic, 6-month OS rates were divided by 10. These scoring points were added for each patient (patient scores). The WBRT-30-BC was compared to the diagnosis- specific graded prognostic assessment (DS-GPA) classification and Rades-Score for breast cancer regarding positive predictive values (PPVs) to identify patients dying within 6 months and patients surviving at least 6 months following WBRT.

Results
On multivariate analysis, Karnofsky performance score (KPS) was significant (risk ratio [RR]: 2.45, p < 0.001). In addition, extra-cerebral metastatic disease (RR: 1.52, p = 0.071) and time between breast cancer diagnosis and WBRT (RR: 1.37, p = 0.070) showed a trend. Based on these three characteristics, four predictive groups were designed: 7–9, 10–12, 13–15 and 16 points. Six-month OS rates were 8%, 41%, 68% and 100% (p < 0.001). PPVs to identify patients dying within 6 months were 92% (WBRT-30-BC), 84% (DS-GPA) and 92% (Rades-Score). PPVs to identify patients surviving for at least 6 months were 100% (WBRT-30-BC), 74% (DS-GPA) and 68% (Rades-Score).

Conclusions
The WBRT-30-BC appeared very accurate in predicting death ≤ 6 months and survival ≥ 6 months of breast cancer patients receiving WBRT. It was superior to previous instruments in predicting survival ≥ 6 months.
The biology and clinical potential of circulating tumor cells
Authors: Lozar Taja , Gersak Klara , Cemazar Maja , Kuhar Cvetka Grasic , Jesenko Tanja 
Published: May 2019

Abstract

Background
Tumor cells can shed from the tumor, enter the circulation and travel to distant organs, where they can seed metastases. These cells are called circulating tumor cells (CTCs). The ability of CTCs to populate distant tissues and organs has led us to believe they are the primary cause of cancer metastasis. The biological properties and interaction of CTCs with other cell types during intravasation, circulation in the bloodstream, extravasation and colonization are multifaceted and include changes of CTC phenotypes that are regulated by many signaling molecules, including cytokines and chemokines. Considering a sample is readily accessible by a simple blood draw, monitoring CTC levels in the blood has exceptional implications in oncology field. A method called the liquid biopsy allows the extraction of not only CTC, but also CTC products, such as cell free DNA (cfDNA), cell free RNA (cfRNA), microRNA (miRNA) and exosomes.

Conclusions
The clinical utility of CTCs and their products is increasing with advances in liquid biopsy technology. Clinical applications of liquid biopsy to detect CTCs and their products are numerous and could be used for screening of the presence of the cancer in the general population, as well as for prognostic and predictive biomarkers in cancer patients. With the development of better CTC isolation technologies and clinical testing in large prospective trials, increasing clinical utility of CTCs can be expected. The understanding of their biology and interactions with other cell types, particularly with those of the immune system and the rise of immunotherapy also hold great promise for novel therapeutic possibilities.
THE ROLE OF NATIONAL LAND AGENCY IN ACCELERATION OF LAND REGISTRATION FOR LEGAL CERTAINTY
Authors: Yamin Muhammad 
Published: May 2019

Observing a lot of land conflicts in Indonesia which is constantly increasing, and followed by the rapidly growing populations that caused the demand for land will also increase automatically. While the number of the available land is limited (not increasing). This condition will surely causes problems on controlling and ownership of the land. This research aims to identify the factors which causes conflict (dispute) of land, by doing inventory to the lands which is owned by the community (whether it is registered or not registered). From this temporary research result, it is known that, the implementation of the land registration in Deli Serdang district (the research location) has not happened as expected. It can be seen from the number of land which has not been registered, this condition will certainly trigger conflicts or disputes in society, both ownership boundary disputes, control of illegal land (arable land), inheritance disputes, etc. Certificate ownership mostly only exist in urban area. The lack of interest by the community to join the land registration is due to various of reasons, which is: 1) the community do not recognized the purpose of land registration, 2) the cost is expensive, 3) the management is convoluted, 4) the community feels that it is not a necessary to do it, 5) arable land. In this research, the role of National Land Agency (NLA) as the organizer of land registration has not been surely prominent, it is visible that the NLA office is more passive, which is only waiting for the arrival of the owner land to register their lands, NLA should be more involved in land registration and followed by socialization, counseling for the community. As well for the land disputes which is in the region of the Land Office until this moment is currently unfinished and still having a lot of problems, in order to achieve the above purpose, Deli Serdang Land Office has taken steps by empowering all the existing abilities, it has been a huge duty for Land Office, by remembering there will be more and more usage and utilization in the future, while the available land is limited, and hoping that the community will be motivated to registered their lands for achieving the legal certainty.
Karl Barthâ€™s RÃ¶merbrief: A Turning Point in Protestant Theology
Authors: Dreyer Wim A. 
Published: May 2019

Karl Barthâ€™s theology presents itself as a paradigm shift during the early part of the 20th century. As time went on, the radical nature of his theology manifested in different ways. Not only did it start out as a critique of Protestant liberal theology, but it also transformed the understanding of the church, mission and basic reformed doctrines such as election. This was met by vociferous protest, from liberal as well as more orthodox theologians. Despite all, PopeÂ Pius XII called Barth the greatest theologian since Thomas Aquinas. This contribution reflects on the first of Barthâ€™s major publications, his RÃ¶merbrief which first appeared in 1919. The point is made that Barthâ€™s RÃ¶merbrief could be regarded as an important turning point in the history of Protestant theology. The context of the RÃ¶merbrief is discussed as well as some of Barthâ€™s early theological views present in it, illustrating the radical break between Barth and the liberal theology of the Modern Era.
Substâncias psicoativas: o uso entre universitários na região oeste de Santa Catarina
Authors: Kolhs Marta , Prado Geisa Percio do , Ascari Tania , Píccoli Sara , Lovison Robson , Bard Laura Caroline de Freitas , Vendruscolo Tainá Aparecida , Nogueira Raquel Ribeiro , Teston Bruna Paula , Colaço Nathalia , Hahn Eliana 
Published: May 2019

Objetivo: Verificar o uso das substâncias psicoativas (SPAs) entre universitários de um Centro de Ensino Superior. Métodos: Optou-se por uma pesquisa quantitativa, epidemiológica transversal. A coleta de dados deu-se por um questionário semiestruturado disponibilizado no Google Formulários; a análise dos dados quantitativos foi feita por meio de uma análise descritiva simples. Participaram da pesquisa 357 universitários dos cursos de enfermagem, engenharia de alimentos, engenharia química e zootecnia. Resultados: Os resultados apontaram que o consumo de substâncias psicoativas por parte desse segmento populacional é maior, quando comparado a população geral; o álcool apareceu como o mais consumido tanto pela quantidade de pessoas quanto nos cursos pesquisados e pela frequência nos últimos três meses, seguida do tabaco e da maconha. O número maior de consumidores está entre as idades de 18 a 24 anos. Quanto à idade em que experimentaram algumas das substâncias pela primeira vez, verificou-se que ocorreu entre os 12 e 17 anos. Conclusão: Os dados apontaram um consumo significativo de substâncias psicoativas, em especial para uso do álcool, tabaco e da maconha. Os resultados também indicaram uso variado de outras drogas, ressaltando uma tendência a experimentação por curiosidade típica da idade e/ou do grupo social.
Pré-Natal de alto risco: dados sociodemográficos e intercorrências durante a gravidez
Authors: Silva Joyce Driely Carvalho , Filha Francidalma Soares Sousa Carvalho , Silva Marcus Vinicius da Rocha Santos da , Silva Emilia Assunção Carvalho , Santos Janderson Castro dos 
Published: May 2019

Objetivo: Analisar as características sociodemográficas e as intercorrências ocorridas com gestantes em Pré-natal de Alto risco em um município situado no nordeste brasileiro. Métodos: Trata-se de uma pesquisa avaliativa, do tipo exploratória, com abordagem quantitativa. Realizada com 95 gestantes, no período de março a setembro de 2017. Os dados foram organizados em um programa estatístico (SPSS) em seguida tabulados, transformados em tabelas e posteriormente feita a análise e interpretação dos mesmos com base na literatura produzida sobre o tema. Resultados: Averiguou-se que a maioria das gestantes (67,4%) está na faixa etária entre 25 e maior ou igual a 36 anos; 67,3% são casadas ou mantém união estável; 57,9% tinham ensino médio completo; 50,5% estavam desempregadas. As principais intercorrências identificadas foram: hipertensão arterial/DHEG (16,8%) abortamento habitual (11,6%), idade superior a 35 anos (10,5%) ou inferior a 15 anos (9,5%). Foi percebido que 91 (95,8%) das gestantes tiveram acompanhamento com enfermeiro, 67 (70,5%) com médico e 38 (40%) com médico ultrassonografista. Conclusão: O principal motivo da presença das gestantes no pré-natal de alto risco foi hipertensão arterial que é reconhecida como uma das principais complicações que levam o risco as gestações, destacou-se também o abortamento habitual e idade superior a 35 anos. Notou-se ainda a insuficiência de profissionais na atenção a uma parte dessas pacientes, visto que essas gestantes necessitam de um acompanhamento multiprofissional.
Assessment of the effect of atmospheric pressure on the level and ground waters flow
Authors: Lavrov S. A. , Markov M. L. 
Published: May 2019

The problem of understanding the interaction of river and ground water waters is intimately bound to questions of formation and unloading of ground waters in river network. The analysis of the previous researches showed that change of atmospheric pressure affects on the water level in observation wells and water discharge of springs. However, the mechanisms of this influence still weren't completely opened. For the solution of this task the complex laboratory, field and theoretical researches including overseeing by a drain, ground water level, atmospheric pressure and air pressure in an unsaturated (vadose) zone were conducted. On the basis of the conducted researches regularities the connecting size of change of ground water level and a drain of ground water waters with atmospheric pressure were received. As a result of generalization field and laboratory researches it was shown that the crucial role in formation of these regularities is played by the area located over a mirror of ground waters with the isolated interstitial air.With an increase in atmospheric pressure, the volume of interstitial air decreases, and at pressure drop volume increases. It, in turn, leads to change in the level and a flow of ground waters. The settlement formula for numerical assessment of variability of level ground depending on atmospheric pressure (barometric efficiency) and degree of air isolation was received from it in an unsaturated zone. As an indicator of isolation, a characteristic is used such as the volume of interstitial air involved in the inflow (outflow) of water into a measuring well or watercourse and not having direct contact with the atmosphere. Research results showed that, in addition to gravitational force in the movement of ground water and the formation of ground water inflow of rivers and lakes, another force plays a certain role - the pressure difference between atmospheric air and air in the unsaturated zone above the aquifer.
Вплив біліопанкреатичного шунтування в модифікації Hess–Marceau на показники ліпідограми у хворих з морбідним ожирінням та дисліпідемією
Authors: Todurov I. M. , Perekhrestenko O. V. , Kosiuchno S. V. , Kalashnikov O. O. , Plehutsa O. I. 
Published: May 2019

Мета. Вивчити вплив біліопанкреатичного шунтування (БПШ) у модифікації Hess–Marceau на показники ліпідограми у хворих з морбідним ожирінням та передопераційною дисліпідемією.
Матеріали і методи. В основу даного дослідження покладено дані клінічного обстеження та результати хірургічного лікування 100 хворих з морбідним ожирінням, яким було виконано БПШ у модифікації Hess–Marceau. Чоловіків було 40, жінок – 60. Середній вік пацієнтів становив (45 ± 8,2) року.
Результати. Лабораторні маркери переважно атерогенних фенотипів дисліпідемії до операції зафіксовано у 75 (75%) хворих. Середній рівень загального холестерину знизився з (6,14 ± 0,9) до (3,7 ± 0,7) ммоль/л, тригліцеридів – з (1,98 ± 0,9) до (1,12 ± 0,4) ммоль/л, регресія коефіцієнта атерогенності – з (3,9 ± 0,9) до (2,3 ± 1,1) через 60 міс після виконання метаболічного втручання (р < 0,05). Показники ліпідограми нормалізувались у 87,0%, покращились – у 13,0% пацієнтів.
Висновки. БПШ в модифікації Hess–Marceau є високоефективною методикою корекції дисліпідемії у хворих з мор-бідним ожирінням.