bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of CXCR2 in the Ac-PGP-Induced Mobilization of Circulating Angiogenic Cells and its Therapeutic Implications
Authors: Kwon Yang Woo , Lee Seung Jun , Heo Soon Chul , Lee Tae Wook , Park Gyu Tae , Yoon Jung Won , Kim Seung-Chul , Shin Ho Jin , Lee Sang Chul , Kim Jae Ho 
Published: November 2018

AbstractCirculating angiogenic cells (CACs) have been implicated in the repair of ischemic tissues, and their mobilization from bone marrow is known to be regulated by the activations of chemokine receptors, including CXCR2 and CXCR4. This study was conducted to investigate the role of N-acetylated proline-glycine-proline (Ac-PGP; a collagen-derived chemotactic tripeptide) on CAC mobilization and its therapeutic potential for the treatment of peripheral artery diseases. Ac-PGP was administered daily to a murine hind limb ischemia model, and the effects of Ac-PGP on blood perfusion and CAC mobilization (Sca1+Flk1+ cells) into peripheral blood were assessed. Intramuscular administration of Ac-PGP significantly improved ischemic limb perfusion and increased limb salvage rate by increasing blood vessel formation, whereas Ac-PGP-induced blood perfusion and angiogenesis in ischemic limbs were not observed in CXCR2-knockout mice. In addition, Ac-PGP-induced CAC mobilization was found to occur in wild-type mice but not in CXCR2-knockout mice. Transplantation of bone marrow from green fluorescent protein (GFP) transgenic mice to wild-type mice showed bone marrow-derived cells homed to ischemic limbs after Ac-PGP administration and that GFP-positive cells contributed to the formation of ILB4-positive capillaries and α smooth muscle actin (α-SMA)-positive arteries. These results suggest CXCR2 activation in bone marrow after Ac-PGP administration improves blood perfusion and reduces tissue necrosis by inducing CAC mobilization. These findings suggest a new pharmaceutical basis for the treatment of critical limb ischemia. Stem Cells Translational Medicine 2019;8:236&246
Seismic performance of corrugated steel plate concrete composite shear walls
Authors: Wang Wei , Ren Yingzi , Han Bin , Ren Tan , Liu Gewei , Liang Yujian 
Published: November 2018

SummaryIn this paper, composite shear walls with different encased steel plates (flat, horizontal corrugated, and vertical corrugated) were tested and simulated by Abaqus to investigate the seismic behavior of corrugated steel plate concrete composite shear walls (SPCSWs). The failure characteristics, deformation and energy dissipation capacity, and stiffness and bearing capacity of the structures under low‐frequency cyclic load were analyzed, and indexes of the seismic performance were obtained. The formulas of the shear‐bearing capacity of steel plate concrete composite shear walls are suggested, and the shear‐sharing ratio of each member is obtained. According to the obtained results, corrugated steel plates can bond with concrete well, and the bearing capacity of the vertical corrugated SPCSW are higher than that of the horizontal corrugated SPCSW. Compared with flat SPCSW, corrugated SPCSW has higher initial stiffness and lateral stiffness, better ductility and energy dissipation ability, and the degradation of bearing capacity and stiffness is slower. The shear‐sharing ratio of a steel plate is larger than that of reinforced concrete in the flat SPCSW and the vertical corrugated SPCSW, the shear force shared by steel plate and reinforced concrete in horizontal corrugated SPCSW is basically the same.
Candida tropicalis biofilm formation and expression levels of the CTRG ALS‐like genes in sessile cells
Authors: Galán‐Ladero María Ángeles , Blanco‐Blanco María Teresa , Fernández‐Calderón María Coronada , Lucio Leopoldo , Gutiérrez‐Martín Yolanda , Blanco María Teresa , Pérez‐Giraldo Ciro 
Published: November 2018

AbstractCandida tropicalis is an emergent pathogen with a high rate of mortality associated with it; however, less is known about its pathogenic capacity. Biofilm formation (BF) has important clinical repercussions, and it begins with adherence to a substrate. The adherence capacity depends principally on the cell surface hydrophobicity (CSH) and, at a later stage, on specific adherence due to adhesins. The ALS family in C. tropicalis, implicated in adhesion and BF, is represented in several CTRG genes. In this study, we determined the biofilm‐forming ability, the primary adherence, and the CSH of C. tropicalis, including six isolates from blood and seven from urine cultures. We also compared the expression of four CTRG ALS‐like genes (CTRG_01028, CTRG_02293, CTRG_03786, and CTRG_03797) in sessile versus planktonic cells, selected for their possible contribution to BF. All the C. tropicalis strains were biofilm producers, related to its filamentation capacity; all the strains displayed a high adherence ability correlated to the CSH, and all the strains expressed the CTRG genes in both types of growth. Urine isolates present, although not significantly, higher CSH, adherence, and biofilm formation than blood isolates. This study reveals that three CTRG ALS‐like genes—except CTRG_03797—were more upregulated in biofilm cells, although with a considerable variation in expression across the strains studied and between the CTRG genes. C. tropicalis present a high biofilm capacity, and the overexpression of several CTRG ALS‐like genes in the sessile cells suggests a role by the course of the biofilm formation.
Rotterdam’s Superdiversity from a Historical Perspective (1600–1980)
Authors: van de Laar Paul , van der Schoor Arie 
Published: November 2018

AbstractThis chapter analyses the major trends in Rotterdam’s migration history in three periods: the early-modern period (1600–1800), the era in which the Working Class Port City was created (1850–1940), and the post-war period until the 1980s. Rotterdam’s pre-industrial history convincingly reveals a multi-ethnic and religious diverse society. Small foreign minorities could have a significant influence on Rotterdam’s cultural, political and economic development. Even strong national identities did not restrict a strong sense of local attachment. The port city of the nineteenth century was less diverse, considering the smaller number of foreign migrants that settled in the city. The migration narrative of the port city in this period is inexorably linked to that of the working city. This narrative became highly popular in the post-war reconstruction period. The offspring of Rotterdam’s nineteenth century rural-urban migrants had rebuilt the city after the fatal German bombardment in May 1940 and had been responsible for its successful post-war industrial port development. The arrival of non-Western migrants in the 1960s and 1970s challenged Rotterdam’s nineteenth century popularised migration narrative. Policy-makers have suggested that this post-war migration process is fundamentally different from older migration patterns. In general, we tend to be too pessimistic about the post war integration and too optimistic about patterns of integration in the past, particularly during the nineteenth century. Notwithstanding the fact that by then the large majority of the migrants were Dutch, marginalisation and exclusion took place on a larger scale than realised. Our long-term perspective hopes to contribute to link earlier migration narratives to Rotterdam’s recent superdiversity.
Laboratory Rotterdam. Logics of Exceptionalism in the Governing of Urban Populations
Authors: van Houdt Friso , Schinkel Willem 
Published: November 2018

AbstractFor some time now, Rotterdam has actively portrayed itself as a policy laboratory. This laboratorial rhetoric, as one could call it, has prevailed in the fields of housing, urban problems and welfare provision, and most recently it has also emerged in the context of Rotterdam as a ‘smart city’. The latter is nothing special, as technological applications to urban problems are full of ‘urban labs’, of experimentation and of what Halpern et al. (2013) have called ‘test-bed urbanism’. However, in the context of urban and social policies in a very general sense, it is less common today. To understand the development of governing diversity in Rotterdam, it is pertinent to scrutinize the character and historical roots of Rotterdam’s laboratorial logic.
Prognoses and Clinicopathological Characteristics for Hepatocellular Carcinoma Originating from the Caudate Lobe After Surgery
Authors: Shimada Shingo , Kamiyama Toshiya , Yokoo Hideki , Orimo Tatsuya , Nagatsu Akihisa , Ohata Takanori , Kamachi Hirofumi , Taketomi Akinobu 
Published: November 2018

AbstractBackgroundThe aim was to evaluate the prognoses and clinicopathological characteristics of solitary hepatocellular carcinoma (HCC) originating from the caudate lobe (HCC‐CL).MethodsWe analyzed 584 patients with a solitary tumor <10 cm from January 1990 to November 2014. Patients were classified into a caudate lobe group (CL; n = 39) and a non‐caudate lobe group (NCL; n = 545). We investigated the prognoses and clinicopathological characteristics of solitary HCC‐CL. We compared the surgical procedures performed in these cases.ResultsHCC‐CL had a similar rate of portal venous invasion (PVI) as HCC‐NCL (21% vs. 19%); however, the frequency of tumor thrombus at the first branch of the portal vein (PV) or extension to the trunk or the opposite side of the PV was significantly higher in HCC‐CL (8% vs. 2%). HCC‐CL had similar OS rates compared to HCC‐NCL; however, HCC‐CL showed significantly poorer RFS. Although there were no significant differences among the three surgical procedures, blood loss and complication rates tended to be higher in cases who underwent an isolated caudate lobectomy. Tumor size ≥5 cm, PVI, and liver fibrosis or cirrhosis (LF or LC) were independent unfavorable factors for both OS and RFS. PIVKA‐II ≥120 mAU/ml was an independent unfavorable factor for RFS.ConclusionHCC‐CL presented a poorer RFS rate. Patients with a tumor size ≥5 cm, PIVKA‐II ≥120 mAU/ml, portal venous invasion, and LF or LC should be diligently followed up as these cases have a high risk of recurrence.
Dispatching and Rescheduling Tasks and Their Interactions with Travel Demand and the Energy Domain: Models and Algorithms
Authors: Botte Marilisa , D’Acierno Luca 
Published: November 2018

AbstractThe paper aims to provide an overview of the key factors to consider when performing reliable modelling of rail services. Given our underlying belief that to build a robust simulation environment a rail service cannot be considered an isolated system, also the connected systems, which influence and, in turn, are influenced by such services, must be properly modelled. For this purpose, an extensive overview of the rail simulation and optimisation models proposed in the literature is first provided. Rail simulation models are classified according to the level of detail implemented (microscopic, mesoscopic and macroscopic), the variables involved (deterministic and stochastic) and the processing techniques adopted (synchronous and asynchronous). By contrast, within rail optimisation models, both planning (timetabling) and management (rescheduling) phases are discussed. The main issues concerning the interaction of rail services with travel demand flows and the energy domain are also described. Finally, in an attempt to provide a comprehensive framework an overview of the main metaheuristic resolution techniques used in the planning and management phases is shown.
Mobile app increases vegetable-based preparations by low-income household cooks: a randomized controlled trial
Authors: Clarke Peter , Evans Susan H , Neffa-Creech Deborah 
Published: November 2018

AbstractObjectiveWe built an app to help clients of food pantries. The app offers vegetable-based recipes, food tips and no-cost strategies for making mealtimes healthier and for bargain-conscious grocery shopping, among other themes. Users customize materials to meet their own preferences. The app, available in English and Spanish, has been tested in a randomized field trial.DesignA randomized controlled trial with repeated measures across 10 weeks.SettingClients of fifteen community food pantry distributions in Los Angeles County, USA.ParticipantsDistributions were randomized to control and experimental conditions, and 289 household cooks and one of their 9–14-year-old children were enrolled as participants. Experimental dyads were given a smartphone with our app and a phone use-plan, then trained to use the app. ‘Test vegetables’ were added to the foods that both control and experimental participants received at their pantries.ResultsAfter 3–4 weeks of additional ‘test vegetables’, cooks at experimental pantries had made 38 % more preparations with these items than control cooks (P = 0·03). Ten weeks following baseline, experimental pantries also scored greater gains in using a wider assortment of vegetables than control pantries (P = 0·003). Use of the app increased between mid-experiment and final measurement (P = 0·0001).ConclusionsThe app appears to encourage household cooks to try new preparation methods and widen their incorporation of vegetables into family diets. Further research is needed to identify specific app features that contributed most to outcomes and to test ways in which to disseminate the app widely.
Comparative institutional advantage: an obituary
Authors: Reale Filippo 
Published: November 2018

AbstractThe article traces the remains of the theory of “comparative institutional advantage”, which was crucial during the early development of the “varieties of capitalism” approach to economics but fell into oblivion quickly afterwards. It follows the discussions of the concept over time and works out possible reasons – theoretical, methodological, and discursive – for the theory's decay. In conclusion, many arguments of the theory seem outdated today but it is a great witness to thezeitgeistof comparative political economy and institutional theory of the millennium.
Gemeinsames Positionspapier der Gesellschaft für Neuropsychologie e. V. (GNP) und des Bundesverband ambulant-teilstationäre Neurorehabilitation e. V. (BV ANR) zum Entlassmanagement nach erworbener Hirnschädigung (insbesondere Schädel-Hirn-Traumata) aus Akut- und Rehakliniken in die weiterführende ambulante Versorgung
Authors: Schock Lisa , Bauer Claudia , Kiesewalter Corina , Kulke Hartwig , Pichler Johannes 
Published: November 2018

Collaborative position paper of the Gesellschaft für Neuropsychologie e.V. (GNP) and the Bundesverband ambulant-teilstationäre Neurorehabilitation e. V. (BV ANR) about discharge management in acute care hospitals and rehabilitation clinics leading to subsequent outpatient treatment after acquired brain injury (especially traumatic brain injury) Abstract. This position paper addresses to neurological, neurosurgical and accident surgical acute care hospitals as well as neurological rehabilitation clinics. It is meant to help facilitate the transition from inpatient to outpatient treatment for people with acquired brain injury, to close treatment gaps and to prevent termination of treatment.
Assessing the Reliability of the CAMS Rating Scale Using a Generalizability Study
Authors: Corona Christopher D. , Gutierrez Peter M. , Wagner Barry M. , Jobes David A. 
Published: November 2018

Abstract. Background: An important consideration when conducting randomized controlled trials is treatment differentiation. Direct observation helps ensure that providers in different treatment groups are delivering distinct interventions. One direct observation method is the use of a measure to rate clinician performance when delivering an intervention. Aims: This generalizability study evaluated the reliability of the CAMS Rating Scale (CRS), a measure used to assess delivery of the Collaborative Assessment and Management of Suicidality (CAMS). Method: Digitally recorded tapes of clinicians delivering either CAMS or Enhanced Care-As-Usual (E-CAU) were coded using the CRS. Sessions ( N = 36) were each coded by two raters, and encompassed four clinicians, four time points, and 34 unique patients across two treatment groups. A reliability coefficient (i.e., G coefficient) and the percentages of variance contributed by each component of the measurement model were obtained. Results: The CRS reliably differentiates CAMS from E-CAU, minimizes measurement error relative to expected variance sources, and continues to demonstrate high inter-rater reliability. Limitations: The absence of blind raters, a formal training protocol for the rating team, and ratings from all clinician–patient dyads at all time points was a limitation. Conclusion: The CRS is a reliable treatment differentiation measure that can play an integral role in studies evaluating CAMS.
Prolonged Monsoonal Moisture Availability Preconditioned Glaciation of the Tibetan Plateau During the Mid‐Pleistocene Transition
Authors: Koutsodendris Andreas , Sachse Dirk , Appel Erwin , Herb Christian , Fischer Tobias , Fang Xiaomin , Pross Jörg 
Published: November 2018

AbstractPaleohydrological data comprising pollen assemblages and leaf‐wax hydrogen isotopes (δDwax) from paleolake sediments in the Qaidam Basin (China) provide evidence for a link between increased moisture availability on the Tibetan Plateau and global cooling during the Mid‐Pleistocene Transition. Notably, they document the persistence of humid and cold conditions during Marine Isotope Stages 24–22 (936–866 ka) suggesting that boundary conditions favorable for extended glaciation on the Tibetan Plateau first developed at ~900 ka. Our δDwax results indicate a strong influence of proximal (monsoonal) moisture sources during that glacial, in agreement with the intensification of the interhemispheric moisture transport resulting from Antarctic ice volume increase at ~900 ka. The consistency of our results with other marine and terrestrial climate data sets suggests that extended glaciation on the Tibetan Plateau may have initiated ~500 ka earlier than previously assumed, implying that midlatitude ice sheets actively contributed to global cooling during the Mid‐Pleistocene Transition.
Comments on “Global Distribution and Variations of NO Infrared Radiative Flux and Its Responses to Solar Activity and Geomagnetic Activity in the Thermosphere” by Tang et al.
Authors: Yue Jia 
Published: November 2018

AbstractThe Tang et al. (2017, https://doi.org/10.1002/2017JA024758) analysis of NO 5.3 μm volume emission rate (VER) data measured by the Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) has several technical problems. First of all, the authors assigned a totally wrong name to the standard SABER NO VER data product calling it “NO infrared radiative flux.” Then they calculated the global distribution, solar cycle, and geomagnetic activity variation of SABER NO VER up to 220‐km altitude, where during solar minimum and geomagnetic quiet times that applied to their analysis there is no valid SABER NO VER observation. Tang et al. also confused Ap index with Kp index when calculating the geomagnetic activity responses. These comments underscore the importance of establishing a clear understanding of the basic knowledge of the satellite, instrument, data products, and upper atmosphere physics when performing these analyses.
Legacy, Rather Than Adequacy, Drives the Selection of Hydrological Models
Authors: Addor N. , Melsen L. A. 
Published: November 2018

AbstractThe findings of hydrological modeling studies depend on which model was used. Although hydrological model selection is a crucial step, experience suggests that hydrologists tend to stick to the model they have experience with, and rarely switch to competing models, although these models might be more adequate given the study objectives. To gain quantitative insights into model selection, we explored the use of seven rainfall‐runoff models based on the abstract of 1,529 peer‐reviewed papers published between 1991 and 2018. The models selected were the Hydrologiska Byråns Vattenbalansavdelning model (HBV), the Variable Infiltration Capacity model (VIC), the mesoscale Hydrological model (mHM), the TOPography‐based hydrologic model (TOPMODEL), the Precipitation Runoff Modelling System (PRMS), the Génie Rural model à 4 paramètres Journaliers (GR4J), and the Sacramento soil moisture accounting model. We provide quantitative evidence of regional preferences in model use across the world and demonstrate that specific models are consistently preferred by certain institutes. Model attachment is particularly strong. In ~74% of the studies, the model selected can be predicted solely based on the affiliation of the first author. The influence of adequacy on the model selection process is less clear. Our data reveal that each model is used across a wide range of purposes, landscapes, and temporal and spatial scales (i.e., as a model of everything and everywhere). Model intercomparisons can provide guidance for model selection and improve model adequacy, but they are still rare (because each model must usually be setup individually) and the insights they provide are currently limited (because they are rarely controlled experiments). We suggest that moving from fixed‐structure models to modular modeling frameworks (master templates for model generation) can overcome these issues, enable a more collaborative and responsive model development environment, and result in improved model adequacy.
A Value‐Based Model Selection Approach for Environmental Random Variables
Authors: Müller M. F. , Thompson S. E. 
Published: November 2018

AbstractEnvironmental decisions with substantial social and environmental implications are regularly informed by model predictions, incurring inevitable uncertainty. The selection of a set of model predictions to inform a decision is usually based on model performance, measured by goodness‐of‐fit metrics. Yet goodness‐of‐fit metrics have a questionable relationship to a model's value to end users, particularly when validation data are themselves uncertain. For example, decisions based on flow frequency models are not necessarily improved by adopting models with the best overall goodness of fit. We propose an alternative model evaluation approach based on the conditional value of sample information, first defined in 1961, which has found extensive use in sampling design optimization but which has not previously been used for model evaluation. The metric uses observations from a validation set to estimate the expected monetary costs associated with model prediction uncertainties. A model is only considered superior to alternatives if (i) its predictions reduce these costs and (ii) sufficient validation data are available to distinguish its performance from alternative models. By describing prediction uncertainties in monetary terms, the metric facilitates the communication of prediction uncertainty by end users, supporting the inclusion of uncertainty analysis in decision making.