bluuebunny/crossref_metadata_2025_split huggingface dataset:
Антиагрегантная активность нового производного индолинона
Authors: Быков Владимир Валерьевич , Чернышева Галина Анатольевна , Смольякова Вера Ивановна , Серебров Владимир Юрьевич , Хазанов Вениамин Абрамович , Удут Владимир Васильевич 
Published: September 2019

Изучена специфическая активность антиагрегантного средства индолинонового ряда (GRS) на модели АДФ-индуцированной агрегации тромбоцитов in vitro и in vivo и на модели стрептозотоцин-индуцированного сахарного диабета у крыс. В качестве препарата сравнения использована (АСК) и дипиридамол. У GRS в опыте in vitro в широком диапазоне концентраций (0,75 · 10–6 – 1,5 · 10–5 М, p < 0,05) отмечается антиагрегантная активность, сопоставимая с таковой у ацетилсалициловой кислоты и дипиридамола. В опытах in vivo показана дозозависимая антиагрегантная активность GRS в дозах 2,5 – 20 мг/кг (21 – 14 %). Увеличение дозы GRS выше 10 мг/кг не приводит к увеличению антиагрегантной активности. При курсовом внутрижелудочном введении в дозе 10 мг/кг GRS обладал антиагрегантной активностью у крыс со стрептозотоцин-индуцированным сахарным диабетом, что проявлялось снижением амплитуды агрегации тромбоцитов до значений в интактной группе (p < 0,05).
FARSÇA TEZKİRE YAZICILIĞI
Authors: KASKA Çetin 
Published: September 2019

Fars edebiyatında en eski tezkire
hicri yedinci yüz yıllın başında Muhammed Avfî’nin telif ettiği Lübâbü'l-Elbâb’tır.
Bu eser şairlerin hal tercümelerinden oluşmaktadır. İsminde "tezkire"
kelimesi geçen ilk Farsça kitaplar, tasavvuf şeyh ve evliyaların halini beyan
eden Attâr’ın Tezkiretü'l-Evliyâ adlı eseri ile ahiret
hakkında bilgi veren, Tezkire-i Nasîrüddîn-i Tûsî adıyla
meşhur olan Risâle-i Âgâz ve Encâm adlı eserdir. İçtimaî ve
siyasi tarihin aydınlatılması noktasında temel bir kaynak görevi üstlenen
Farsça tezkireler genellikle mukaddime, asıl metin ve hatimeden
oluşmaktadır. Bu makale İran'da yayınlanan Dânişnâme-i Cihân-i İslâm
adlı eserde geçen "Tezkire Nivîsî-yi Fârsî" maddesinin tercümesidir.
Bu çalışmada Farsça tezkire yazıcılığı hakkında bilgi verilmiş ve hangi
dönemde ne tür tezkirelerin yazıldığı beyan edilmiştir.
NEBÎ B. TURHAN ES-SİNOBÎ (ö.936/1530)’NİN TASAVVUFÎ DÜŞÜNCEYE YÖNELTTİĞİ TENKİTLER
Authors: YILDIRIM Birol 
Published: September 2019

Osmanlı Devleti’nin kuruluş
döneminde medrese-tekke müesseseleri arasında ciddi bir denge kurulmuş, tekke
çevreleriyle medrese çevrelerinin yakınlaşması sağlanmıştır. Muhyiddin
Arabî’nin Ekberiyye mektebinin önemli bir temsilcisi olan Davud-i Kayserî 1331’de
İznik’te­ kurulan ilk medresenin başına,
aynı düşünce ekolünden Molla Fenarî ise ilk defa tesis edilen şeyhü­lislamlık
makamına getirilmiştir. Bu sayede tasavvufî düşünce Osmanlı medrese sistemine
ve ilmiye sınıfına nüfuz etmiş, mutasavvıf alim tipi yaygınlaşmıştır. Medrese
eğitimini ikmal ettikten sonra tekke eğitimine de vakıf olan mutasvvıf
alimlerin eserleri kelam, fı­kıh ve tasavvufu mezcederek meseleleri küllî bir
bakış açısıyla zahir ve batın perspektifinden ele almışlardır. Fakat bu denge
zamanla bozulmuş ve tarikat mensuplarıyla devlet adamları ve medrese çevreleri
arasında gerginlikler yaşanmıştır. Bu gerginliğin odak noktasında
İbnü’I-Arabî’nin dile getirdiği bazı görüşler ile cehrî zikir, sema, devran
gibi hususlar yer almıştır. Şeyhülislam İbn Kemal gibi bazı alimler
İbnü’l-Arabî lehinde fetvalar verirken, XVI. Yüzyılda yaşamış olan Sinoplu
Abdülbarî b. Turhan, İbrahim b. Muhammed Halebî, Şeyhülislam Çivizade Muhyiddin
Mehmed Efendi gibi alimler ise İbnü’l-Arabî'nin görüşlerine karşı çıkmaya devam
etmişlerdir. XVll. yüzyılda ortaya çıkarak Osmanlı ilmiye sınıfına otuz yıl
civarında damgasını vuran Kadızadeliler ise tasavvufî düşünceye muhalefeti
devam ettirmişlerdir.

Biz bu çalışmamızda Osmanlı
Dönemi’nin önemli bir tasavvuf muhalifi olan Nebî b. Turhan es-Sinobî’yi ele
alçağız. “Hayâtü’l Kulûb”ve “Risale fi Vahdetü'l-Vücud” adlı eserlerinde
Muhyiddin İbnü’l-Arabî Hazretleri’nin şahsıyla özdeşleşmiş olan vahdet-i vücûd/tevhîd-i
vücûdî anlayışı başta olmak üzere tasavvuf ekolüne tekfire varan aşırılıkta
yönelttiği ağır eleştirileri değerlendireceğiz. Onun şahsında Osmanlı döneminde
etkili olup günümüze kadar tesirini sürdüren “dinde tasfiyecilik/puritanizm”
akımını ele alacağız. Böylelikle Sinoplu bir âlimin fikir ve düşünce dünyasını
ve geçmişten günümüze entelektüel düzeyde önemli bir çatışma alanı olan
zâhir-bâtın meselesini objektif bir şekilde nazara vermeye çalışacağız.
DEDE KORKUT HİKÂYELERİ’NDE ANNE ARKETİPİ BAĞLAMINDA OTAĞ SEMBOLÜ
Authors: ALSAÇ Fevziye , ALSAÇ Gönül 
Published: September 2019

Dede Korkut Hikâyeleri, Türk toplumunun kültürel
kodlarını anlatı geleneğine dönüştüren başyapıtlarından biridir. Bu anlatılar, Türk insanının düşünüş ve duyuş tarzını
destansı bir anlatımla ebedileştirir. Dede Korkut Hikâyeleri’nde otağ, insan ve
mekân ilişkisini ifade eden arketipsel bir semboldür. Ev/otağ, Türk insanının
geleneksel inanışlarıyla fiziksel doğumunu ruhsal doğumuyla tamamlayan, otantik
gelişimini ve aslî kimliğini yansıttığı özel ve simgesel bir mekândır. Ev/otağ,
özel mekânın ve aitliğin simgesel göstergesidir. Kendini ait hissetme olgusunun
dönüşüm formudur.

Anne arketipi, dişil bir imge
olarak; ocak/yuva bağlamıyla aileyi sembolize eder ve yurt arketipiyle de
ilişkilidir. Yurt arketipi, aitlik ve ilksel mekân bağlamını taşıyan ezelî bir
imgedir. Türk kültüründe ev/yuva ocaktır; ocağın ateşi ve dumanının tütmesi
yönüyle ocak, aileye benzetilir. Kırmızı güney yönlüdür ve gücü, kuvveti, ateşi
sembolize eder. Sıcak ve canlı olan kırmızı/al renk Dede Korkut Hikâyeleri’nde
kadını, gücü, aileyi ifade eder. Dede Korkut Hikâyeleri’nde otağ olgusal mekân
bağlamıyla sembolik bir dil koduna dönüşür. Otağ mekânı toplumsal düzenin ve
kültürel kimliğin taşıyıcısı olarak olay örgüsünde anlamlar üretir.

Türk toplumunun değerleriyle ve
gelenekleriyle dizayn edilen otağ/çadır; yuva bağlamıyla yeryüzü ve gökyüzü
arasında kendini ifade etmeye çalışan göçebe bir toplumun kültürel mekânını
ifade eder. Bu çalışmada Dede Korkut Hikâyeleri’nde otağ/çadır mekânıyla
simgeleşen anne arketipi ve yurt imgesi hikâyelerden örneklerle açıklanmıştır. Mekânın
geleneksel bir dokuyla aktardığı aile ve ocak ifadeleri özel alan bağlamıyla
yorumlanmıştır. Ayrıca hikâyelerden hareketle otağın anlamsal dönüşümlerle
kahraman ve kahramanın eylemlerine yön veren sembolik okumaları çözümlenmiştir.
Çalışmada edebî eserlerin çözümlenmesinde kullanılan yorum bilim yöntemi
kullanılmıştır.
Ocular Pulse Amplitude in Non-Diabetic Patients with End Stage Renal Disease and Normal Individuals Using Dynamic Contour Tonometry
Authors: C P Shimna , R Arathi Simha , David Vinoi George , Varughese Santosh , Abraham Lekha Mary 
Published: September 2019

Introduction: Ocular Pulse Amplitude (OPA) is the fluctuation of IOP with the cardiac cycle which is equal to the difference between systolic and diastolic IOP. These variations in IOP are thought to be caused by the blood volume that is pumped into the eye, mainly the choroidal bed during each cardiac cycle. In patients with end stage renal disease (ESRD), Choroidal perfusion has been found to be reduced as determined by Indocyanine Green Angiography (ICG) which is an invasive procedure. OPA is recorded by Dynamic Contour Tonometer (DCT) which represents a potential new technology for measuring choroidal blood flow indirectly & non-invasively especially in patients with suspected compromise in perfusion as in ESRD. In this study we postulate that measurement of OPA can be used to assess the choroidal perfusion inpatients with ESRD.
Objectives: To measure OPA in non-diabetic patients with ESRD on hemodialysis and to compare it with that of OPA in age matched normal individuals.
Materials & Methods: It was a prospective Cross-sectional study and was done in a clinical set up during the period of January 2013 to October 2013. OPA among 44exposed and 44 non exposed individuals were measured using Dynamic Contour Tonometry (DCT) and analysis done.
Results: The mean OPA in non diabetic patients with ESRD was 1.945mm Hg (CI:1.847 – 2.043) and the mean OPA in age matched normals was 2.16mm Hg (CI: 2.08– 2.24).
Conclusion: OPA in non diabetic ESRD patients was statistically significantly lower than that of age matched normals (p=0.03). There was no correlation between OPA and other parameters like age, gender, intraocular pressure, blood pressure or serumcreatinine levels.
Choroidal Melanoma: Our Experience
Authors: Hamal Diwa , Limbu Ben , Sthapit Purnima Rajkarnikar , Pradhan Eli , Shrestha Reshmi , Saiju Rohit 
Published: September 2019

Background: Choroidal melanomas are diagnosed in approximately 6 out of one million Americans per year, and although their incidence is low, they are the most common primary intraocular tumor in adults.
Methods: Choroidal melanoma is rare tumors and till date no such reports with sclera involvement has been reported from Nepal. It is a prospective case series. The aim of this study is for awareness of the severity of the Choroidal melanoma and it’s management. Besides, it is also to study the demography, presentation, histopathological variations and management of cases of choroidal melanoma. All the consecutive cases of Choroidal melanoma presenting between Jan 2017 to May 2018 and those who were within the inclusion criteria were included in this study.
Results: There were eight patients, five male and three female, within age range of 18-73, median age was 47. All patients presented with decreased vision ranging from 6/24 to PL of less then three months to 2 years duration. Fund us showed choroidal mass associated with Vitreous hemorrhage (VH), and retinal detachment (RD). Two patients were managed with enucleation with External beam radiotherapy (EBRT). Four underwent only enucleation. One patient with lesion size less then 10mm under went plaque brachy therapy. One patient underwent initially Plaque brachy therapy but later had to undergo Enucleation. Histopathological examination (HPE) of enucleated patient revealed epitheloid cell melanoma grade three in four and Spindle cell melanoma in three patients. Each one patient of epitheloid cell melanoma and spindle cell melanomahad scleral involvement. Indication for radiotherapy was scleral involvement.
Conclusion: With 8 cases of Choroidal melanoma in a single year in a single hospitalgives us a clue that there may be much more undiagnosed cases of Choroidal melanomain Nepal that should be taken seriously. Going for annual eye examination with routine dilated fund us exams can help in prevention and early diagnosis of this life and sight threatening condition and to reduce the mortality rate.
A rare case of conjunctival malignant melanoma with orbital invasion
Authors: Rajbhandari Yogita , Gupta Sharad , Yadav Reena , Manandhar Ashma , Mon Aye Myat , Joshi Pramiti , Shrestha Gulshan Bahadur 
Published: September 2019

Background: Conjunctival malignant melanoma is a rare ocular malignancy most commonly affecting mostly the elderly population. It is a pigmented lesion which canarise from primary acquired melanosis, de novo or from preexisting nevus.
Case: A 63 year old male presented with a chief complaints rapidly increasing mass in the left eye for two months following trauma with a wooden stick. He had preexisting nevus in the same eye. His best corrected visual acuity was 6/12 in right eye and 1/60 left eye respectively. Slit lamp biomicroscopy examination showed 4 cm x 4 cm pigmented mass in the nasal bulbar and inferior palpebral conjunctiva causing mechanical ectropion of the lower lid with keratinization of palpebral conjunctiva. Incisionalbiopsy of conjunctiva showed malignant melanoma. On computed tomography, there was expansion of bony orbit. Considering all the findings, exenteration of the left orbitwas done. Histopathological report of exenterated mass was suggestive of malignantmelanoma of conjunctiva.
Conclusion: Conjunctival melanoma is a rare malignant tumor of eye which has high metastasis rate and the treatment option is surgery with adjuvant therapy.
Ocular ischemic syndrome; A case report
Authors: Benjankar Manju , Sitaula Sanjeeta , Karki Pratap 
Published: September 2019

Background: Ocular ischemic syndrome is not a common condition so most of these cases are often misdiagnosed or treated as a different entity. Therefore, it is very important for the ophthalmologists to have this condition in mind as a differential so that the patients can be diagnosed and treated as early as possible. A 42 years female presented with painless, progressive diminution of vision in right eye over the period of 1 month. She doesn’t give any history of redness of eyes, fever or trauma. There is no history of diabetes mellitus or hypertension as well. On examination, vision in right and left eyes was 1.78 and 0.30 Log Mar Units respectively. On anterior segment examination, revascularization of iris (1o 4 ‘o’clock hrs) in right eye was noted. On dilated fund us copy, revascularization of disc (1/3rd) was present in right eye. Cotton wool spots blot hemorrhages and micro aneurysms were also noted in right eye. Likewise, attenuation of arteries were noted on both sides. Fund us fluorescent angiography revealed delayed artery covetous and venous phase. Carotid Doppler was done which showed complete occlusion of right common carotid and bilateral internal carotid artery. These findings lead to the diagnosis as ocular ischemic syndrome so she was then referred to the cardiologist who further confirmed that no active intervention was required at present. The patient was planned for right eye pan retinal photocoagulation (PRP) and was completed in 2 sittings and was asked to follow up regularly.
Conclusion: Early diagnosis and management is very important for uncommon conditions such as ocular ischemic syndrome to prevent further complications.
A History of Wrought Aluminum Alloys and Applications
Authors: Sanders Robert , Staley James 
Published: September 2019

Abstract
The development of aluminum alloys has progressed along two tracks: heat treatable and non-heat treatable. The Aluminum Association alloy composition limits and product temper are defined for major alloying elements. This article summarizes the historical evolution of the different series of wrought aluminum alloys (1xxx to 8xxx) and discusses their applications based on the alloying system introduced by the Aluminum Association.
Predict the Lifetime for (15.75 kV/400 kV) Transformers Oil of NASIRIYAH Power Plant
Authors: صايل وارد وارد , تركي عطية باقر , عبد حجاي سمير , علاوي محسن عماد 
Published: September 2019

The Nasiriyah thermal power plant considered to be within the aging stations of the Iraqi electric power grid which reflected on the performance of operating transformers. Recently, several cases of repeated transformer damage have been reported, which reinforce the need to investigate the causes behind that since the transformer ultimate importance in reliable power supplies for the consumers. As a result of that a priority of investigation have grown to calculate the remaining default life of transformer oil due to its vital role in the processes of insulation and cooling.
In this work, the lifetime for transformer oil of the Nasiriyah thermal power plant (15.75 kV/ 400 kV) four transformer that are similar in specification and different in loading values has been investigated. Some oil samples was drawn from the oil used in each transformer in order to conduct measuring tests of variables values (flashpoint, breakdown voltage, viscosity, acidity). All tests have been carried out at high voltage and chemical laboratories. The obtained result showed a widely change in the acidity values, coupled with its entry into bad oil classification, while it shows acceptable change with standard specification for remaining variables. An acidity limit of (0.3 mg KOH/g oil) has been recorded as a major variables to calculate oil lifetime according to the international (IEC-296) standard. Technique for acceleration test has been developed and employed to develop oil lifetime equation by testing the oil samples in high varying temperatures (130 °C, 140 °C, 150 °C) with continuous monitoring of the acidity limit.
The obtained results show the validity of these proposed equations to calculate the oil lifetime after their compliance with the four transformer loading rates. The results also show a presence of a serious decline in oil life time at the prevailing operating temperatures for all transformers especially for the highest load rate transformer (AT4) for range between (50 °C- 60 °C). For example, the lifetime prediction of transformer (AT4) a temperature of 60 °C is 3.5 years. A set of recommendations are suggested in order to evade transformer failure. It has been concluded that the oil used in transformer (AT4) should be replaced. Extra oil should be added to (AT1, AT2, AT3) transformers.
La gobernanza en el deporte: la legitimidad en la federación colombiana de atletismo un estudio de caso de tipo explicativo.
Authors: Oliveros Gabriel Sebastián Eduardo 
Published: September 2019

Este artículo, tiene como objetivo, determinar el estado de la Gobernanza - Legitimidad en la Federación Colombiana de Atletismo, y, así mismo, su nivel de desarrollo con la Federación Internacional. El estudio se centra en la evaluación de la Federación Colombiana de Atletismo (ligas deportivas, el comité olímpico colombiano y Coldeportes). Los datos obtenidos, se recopilaron a través del documento de observación generado por la asociación “Play The Game” y ajustado a las necesidades del sistema nacional del deporte. Metodológicamente, se divide en tres fases. En la primera fase, se describió el origen de la investigación y se desarrolló un marco conceptual, que va de lo general a lo particular, para, finalmente, centrarlo en la Federación Nacional Deportiva de Atletismo. En la segunda fase, se llevó a cabo la ejecución del instrumento “Sports Governance Observer 2015: the legitimacy crisis in international sports governance”. En la tercera fase, se realizó un análisis del instrumento aplicado a cada principal, con el fin de obtener conclusiones sobre el estado de cada indicador. Los resultados, son presentados de acuerdo con cada uno de los indicadores evaluados por el instrumento utilizado. Además, es necesario aclarar que, de acuerdo con la revisión bibliografía se encontraron 9.668 artículos. Sin embargo, únicamente 35 de ellos fueron hallados como funcionales: Scopus (1), ProQuest (18), Science direct (5), Sportdiscus (1), Google académico (10).
Editorial
Authors: Gracia Díaz Álvaro José 
Published: September 2019

El manuscrito sometido a la Revista Digital: Actividad Física y Deporte, con fines de ser publicado, se sujeta a revisiones internas, que verifican el seguimiento de las normas para la elaboración de los artículos e instrucciones para los autores y la factibilidad de ser aceptado o rechazado. De esta primera verificación, por lo general, se devuelve a los autores con comentarios, para los ajustes correspondientes o un veredicto, en el caso de no aceptación.
Una vez corregido el texto por parte de los autores, se revisa nuevamente, y sí, no se presentan inquietudes adicionales, se remite a evaluación externa, que será realizada por los pares anónimos, en un 90% con filiación externa a la Universidad de Ciencias Aplicadas y Ambientales U.D.C.A. Los expertos diligencian el formato de: "Evaluación de manuscritos sometidos a la Revista Digital: Actividad Física y Deporte", específico para manuscritos de investigación, de reflexión y de revisión; además, se les solicita hacer comentarios y correcciones al texto, que permiten mejorar el contenido. Ocasionalmente, se solicita la evaluación a un tercer par.
Los conceptos emitidos por los pares evaluadores, se transmiten vía correo electrónico a los autores, bajo el sistema doble ciego, quienes deben acatar las sugerencias y las correcciones; no obstante, los autores tienen el derecho de justificar la no aceptación de los conceptos. El conjunto de la revisión de los conceptos, de los textos ajustados y de las posibles justificaciones de la no aceptación, comprende la decisión de la aprobación o del rechazo del artículo. Todo este proceso, se hace en formato digital, va a un repositorio de correos electrónicos, con soporte físico. Los artículos aceptados se someten a la revisión orto-topográfica y el paso siguiente es la diagramación e impresión.
En este momento la Revista Digital: Actividad Física y Deporte adelanta el proceso de indexación ante Colciencias, con este proceso se busca seguir fortaleciendo su estructura, visibilidad a través de la implementación y liberación del Open Journal Systems (OJS) y la asignación del Digital Object Identifier (DOI), así como, el manejo de las redes sociales, para fortalecer el impacto de la revista y el nivel de calidad científica de los artículos que se van a publicar.
LA LÚDICA ESTRATEGIA CURRICULAR PARA LA CONVIVENCIA ESCOLAR
Authors: Noy Martínez Miguel  Orlando , Jaimes Jaimes Gladys 
Published: September 2019

Las actividades lúdico-pedagógicas son de gran importancia para la disminución de las conductas agresivas en los estudiantes. El objetivo de esta investigación fue Implementar un programa lúdico para mejorar la convivencia escolar del grado cuarto del colegio Coopteboy de la ciudad de Tunja. Esta investigación está dentro del enfoque mixto, relacionando datos cuantitativos y cualitativos, a través de una triangulación de instrumentos de recolección de información. El diseño en que se fundamentó este proyecto, se basó en las fases de la investigación acción. La unidad de trabajo fue el grado cuarto compuesto por 20 estudiantes (11 niños y 9 niñas) de la institución educativa Coopteboy de la ciudad de Tunja con edades comprendidas entre los 9 y 11 años, de estratos 3 y 4, donde la mayoría de los/as estudiantes se caracterizaron por ser hijos únicos. Las Conclusiones de este trabajo investigativo, se encuentra que debido al programa lúdico implementado, la convivencia escolar mejoró notablemente y que el trabajo en equipo logra disminuir los problemas convivenciales. Es importante modernizar el sistema educativo para que la lúdica deje de ser exclusiva del tiempo libre y sea incorporado en el desarrollo de los procesos curriculares para una mejor enseñanza y convivencia escolar.