bluuebunny/crossref_metadata_2025_split huggingface dataset:
EVALUATION OF MEDICATION COMPLIANCE IN PATIENTS WITH CONGESTIVE HEART FAILURE IN YEMEN
Authors: MOHAMMED AL-Z AL-ZAAZAAI ET AL ALI AHMED , AL-AMRANI MANSOUR A. , ALAKHALI KHALID , ALJABER NOURADDEN 
Published: April 2019

Objective: Non-compliance with heart failure medication is related to the highest mortality, morbidity, and health-care costs. The objective of this study was to evaluate medication compliance with patients with congestive heart failure.
Methods:Inpatients of the cardiac care unit and medical ward of Republican Hospital, German Hospital, Revolutionary Hospital, and Chinese–Yemeni Friendship Hospital were recruited for this study. The study was conducted on patients that were diagnosed as having congestive heart failure and were receiving treatment. Questionnaires were distributed and personal interviews to evaluate the patients’ compliance was conducted to determine the reasons for their non-compliance in taking drugs.
Results: Of 86 patients, 44% (n = 38) reported compliance and 56% (n = 48) reported non-compliance. The distribution of the patients in terms of sex was as follows: among men, 41% (n = 24) were compliant and 59% (n = 35) were non-compliant; among women, 52% (n = 14) were compliant and 48% (n = 13) were non-compliant. In addition, smoking status was too significantly linked with non-compliance (P = 0.001). Furthermore, the status of chewing of khat tree leaves was also significantly associated with non-compliance (P = 0.007).
Conclusion: This study indicates that the reasons for non-compliance with medications among patients can be attributed to lack of education, chewing of khat tree leaves, lack of health insurance, and cigarette smoking. Therefore, healthcare professionals should create strategies to address these reasons in order to increase medication compliance with patients in heart failure.
DRUMSTICK MUCILAGE MICROSPHERES FOR CONTROLLED RELEASE OF LAMIVUDINE: DESIGN, OPTIMIZATION AND IN VITRO EVALUATION
Authors: Gada Santosh G , Y. ANANDKUMAR , SETTY C. MALLIKARJUN 
Published: April 2019

Objective: The objective of this study was to design and evaluate controlled release mucoadhesive microspheres of lamivudine using mucoadhesive polymers and mucilage.
Methods: Mucoadhesive microspheres of lamivudine were formulated by ionic gelation method. The response surface methodology was adapted for optimization of formulation using central composite design (CCD) for two factors at three levels each was employed to study the effect of independent variables, Sodium alginate-drumstick mucilage (X1) and calcium chloride (CaCl2) concentration (X2) on dependent variables, namely drug encapsulation efficiency (DEE) and particle size (PS). Optimized drumstick mucilage mucoadhesive microspheres of lamivudine were obtained by using numerical optimization of desirability approach. The observed microspheres were coincided well with the predicted values by the experimental design.
Results: The microspheres formed were spherical in shape, and Particle size (PS) ranged between 681.63-941.57μm. Drug encapsulation efficiency (DEE) was ranged between 69.63-94.56 %. The drug release for an optimized formulation was 96.58 %. The mechanism of drug release from microspheres followed Korsemeyer’s-Peppas and exponential ‘n’ value was greater than 0.45, indicating the drug release was non-fickian i.e., swelling followed by erosion mechanism.
Conclusion: This work suggests that mucoadhesive microspheres, an effective drug delivery system for lamivudine, can be prepared using drumstick mucilage in improving the bioavailability of the drug.
DEVELOPMENT AND VALIDATION OF SENSITIVE LC-ESI-MS/MS METHOD FOR THE SIMULTANEOUS ESTIMATION OF DAPAGLIFLOZIN AND SAXAGLIPTIN IN HUMAN PLASMA
Authors: Adluri Phanindra , Y Shravan Kumar 
Published: April 2019

Objective: To develop and validate a sensitive liquid chromatography-electrospray ionization-tandem mass spectrometric (LC-ESI-MS/MS) technique for the quantification of dapagliflozin and saxagliptin in plasma by linagliptin as internal standard.
Methods: Chromatography was achieved on hypersil C18 (50 mmx4 mm) 5 µ analytical column with 0.1% formic acid and acetonitrile (25:75 V/V) as mobile phase at 0.7 ml/min flow rate. Dapagliflozin, saxagliptin, and linagliptin were detected at m/z 409.14/135.0, m/z 316.2/180.13 and m/z 472.54/456.21 respectively. Drugs and internal standard were extracted by LLE (liquid-liquid extraction).
Results: Developed technique was validated over 0.5-1500.0 ng/ml linear concentration range for dapagliflozin and 2.00-2000.0 ng/ml for saxagliptin. This method established with intra-batch and inter-batch precision within 2.44-8.12% and 1.25-7.14 % for dapagliflozin and 1.84-7.5 % and 1.02–6.00 % for saxagliptin. This method established with intra-batch and inter-batch accuracy for dapagliflozin within 98.86-103% and 96.98-102 % respectively and for saxagliptin within 98.05-109.06 % and 97.00-104.00 % respectively.
Conclusion: Both dapagliflozin and saxagliptin were stable during three freeze-thaw cycles, long term and bench-top stability studies. The developed method was useful for the routine analysis of dapagliflozin and saxagliptin simultaneously in plasma samples.
SIMPLE METHOD FOR OPTIMIZATION OF HEPARIN AND ENOXAPARIN DETECTION USING AGAROSE GEL ELECTROPHORESIS
Authors: Almeman Ahmad Abdulrahman 
Published: April 2019

Objective: A simple gel electrophoresis method for low-molecular-weight heparins (LMWH) is required for use in a variety of laboratories to allow further identification and purification. This study aimed to optimize the detection of heparin and enoxaparin (low-molecular-weight heparin by gel electrophoresis.
Methods: Several gel electrophoresis conditions were tested to optimize the detection of enoxaparin by using a simple method with a modified Volpi’s approach. Multiple gel thicknesses, voltage settings, and enoxaparin concentrations were tested in the optimization procedure. Enoxaparin was purchased from a local supplier as pre-filled pharmaceutical injections. Highly purified 0.5% and 1.0% agarose gels were prepared and a series of enoxaparin concentrations was added to both gels for comparison and optimization. The 0.2% toluidine blue stain was prepared by the addition of 1 ml in an ethanol-water-acetic acid mixture (50:49:1; v/v/w). The staining process comprised two steps: first, toluidine blue was added for 30 min and destained overnight in the solvent mixture. Subsequently, the following morning, the second step was conducted, in which the gel was restained for 30 min with the same concentration of toluidine blue. We continued to stain the gel until the bands were visible.
Results: The gel electrophoresis results showed that clearest and sharpest bands were obtained using 65–75 mAh and 85 V settings. At 95 mAh, the bands were slightly washed out.
Conclusion: This study successfully facilitated the detection of enoxaparin, a LMWH, and heparin in the laboratory by using simple tools and techniques available in most laboratories.
3D QSAR AND DOCKING STUDY OF INDOLE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS
Authors: Chavan Rajashree , MORE HARINATH 
Published: April 2019

Objective: Non-steroidal anti-inflammatory agents (NSAIDs) continue to be one of the most widely used groups of therapeutic agents. QSAR (quantitative structure-activity relationship) approach is a very useful and widespread technique for drug design. 3D QSAR facilitates evaluation of three-dimensional molecular fields around molecules and generates a relationship of these fields' values with the activity.
Methods: 3D QSAR study was performed on selected twenty-four compounds from synthesized indole derivatives using the stepwise variable selection k-nearest neighbor (kNN) molecular field analysis approach for indicating the contribution of the steric and electronic field for activity. The docking study was performed to further confirm the binding affinity of synthesized molecules (ligands) to COX-2 enzyme as well as to study binding nature.
Results: Statistically significant model was generated using VLife Molecular Design Suite 3.5 software with cross-validated correlation coefficient q2 of 0.9461 and high predictive correlation coefficient (Pred_r2) of 0.8782 indicating that the model is robust. The results of docking study suggest that the synthesized compounds have a comparable binding affinity with the COX-2 enzyme.
Conclusion: The present study may prove to be helpful in the development and optimization of existing indole derivatives as anti-inflammatory agents with selective COX-2 inhibition.
Relaciones cuantitativas estructura-actividad/propiedad en dos dimensiones empleando el programa R
Authors: Dominguez Dueñas Laura , Goode-Romero Guillermo , Aguayo-Ortiza Rodrigo 
Published: April 2019

<p style="text-indent: 0.13in; margin-bottom: 0in; line-height: 100%;" align="justify"> </p><p style="text-indent: 0.13in; margin-bottom: 0in; line-height: 100%;" align="justify"><span style="color: #000000;"><span style="font-family: Times New Roman, serif;"><span style="font-size: medium;">Las relaciones cuantitativas estructura-actividad (</span></span></span><span style="color: #000000;"><span style="font-family: Times New Roman, serif;"><span style="font-size: medium;"><em>QSAR</em></span></span></span><span style="color: #000000;"><span style="font-family: Times New Roman, serif;"><span style="font-size: medium;">) y estructura-propiedad (</span></span></span><span style="color: #000000;"><span style="font-family: Times New Roman, serif;"><span style="font-size: medium;"><em>QSPR</em></span></span></span><span style="color: #000000;"><span style="font-family: Times New Roman, serif;"><span style="font-size: medium;">) son modelos matemáticos aplicados a la predicción de actividades biológicas o propiedades de un grupo de compuestos. Estos modelos son generados y validados por análisis estadístico a partir de un grupo de moléculas con una actividad biológica o propiedad conocida. En este trabajo se explica la metodología general para realizar un análisis </span></span></span><span style="color: #000000;"><span style="font-family: Times New Roman, serif;"><span style="font-size: medium;"><em>QSAR/QSPR</em></span></span></span><span style="color: #000000;"><span style="font-family: Times New Roman, serif;"><span style="font-size: medium;"> utilizando el lenguaje de programación de </span></span></span><span style="color: #000000;"><span style="font-family: Times New Roman, serif;"><span style="font-size: medium;"><em>R</em></span></span></span><span style="color: #000000;"><span style="font-family: Times New Roman, serif;"><span style="font-size: medium;">, analizando como caso de estudio la predicción del transporte a través de la barrera hematoencefálica.</span></span></span></p><p style="text-indent: 0.13in; margin-bottom: 0in; line-height: 100%;" align="justify"><span style="color: #000000;"><span style="font-family: Times New Roman, serif;"><span style="font-size: medium;"><br style="font-size: medium;" /></span></span></span></p>
Penerapan Model Paired Storytelling dalam Pembelajaran Bercerita
Authors: Hesti Resmi Suryaning 
Published: April 2019

Penelitian ini bertujuan, mengetahui bagaimana penerapan model Paired Storytelling untuk meningkatkan motivasi belajar siswa kelas V SD Negeri Kumendung Rembang, mengetahui kelebihan, kekurangan, kendala penerapan model Paired Storytelling pada siswa kelas V SD Negeri Kumendung Rembang. Penelitian ini merupakan penelitian kualitatif. Subjek penelitian diambil dari siswa kelas V sebanyak 30 orang. Teknik pengumpulan data menggunakan Nonprobability Sampling. Data dalam penelitian ini diperoleh melalui observasi, dokumentasi, dan tes. Setting penelitian ini di SD Negeri Kumendung Rembang. Hasil penelitian menunjukkan bahwa, Penerapan model paired storrytelling dalam pembelajaran bercerita oleh kelompok 1 mendapat prosentase 80%, Kelompok 2 mendapat prosentase 65%, Kelompok 3 mendapat prosentase 75%, Kelompok 4 mendapat prosentase 80%. Kelompok 5 mendapat prosentase 70%, Kelompok 6 mendapat prosentase 75%, Kelompok 7 mendapat prosentase 75%, Kelompok 8 mendapat prosentase 55%, Kelompok 9 termasuk mendapat prosentase 80%, serta penerapan model paired storrytelling dalam pembelajaran bercerita oleh kelompok 10 mendapat prosentase 65%. Dengan demikian diatas dapat disimpulkan bahwa penerapan model paired storrytelling mampu meningkatkan motivasi belajar siswa kelas V SD Negeri Kumendung Rembangpada kelas V SD Negeri Kumendung Rembang
Penerapan Model Pembelajaran Berbasis Masalah untuk Meningkatkan Hasil Belajar
Authors: Lutfita Sari Tria , Dewi Koeswanti Henny 
Published: April 2019

Penelitian tindakan kelas ini dilakukan untuk meningkatkan hasil belajar Tema 6 Subtema 3 Pembelajaran 1 dan 2 dengan menerapkan model Pembelajaran Berbasis Masalah pada siswa kelas V yang terdiri dari 16 siswa. Meningkatkan hasil belajar Tema 6 Subtema 3 Pembelajaran 1 dan 2 dengan menerapkan model Pembelajaran Berbasis Masalah. Faktor-faktor yang menyebabkan peningkatan hasil belajar Tema 6 Subtema 3 Pembelajaran 1 dan 2 dengan penerapan model Pembelajaran Berbasis Masalah Siswa Kelas V SD N Kutowinangun 10 Salatiga. Subjek penelitian adalah siswa kelas V dengan jumlah 16 siswa. Hasil penelitian adalah peningkatan hasil belajar sebelum tindakan dilakukan untuk siklus I dan siklus II. Hasil belajar pada pra siklus dengan persentase 31,25%, kemudian ada peningkatan di siklus I dengan persentase 43,75%. Selanjutnya hasil belajar siklus II meningkat dengan persentase 81,25%, dibuktikan dengan adanya penerapan model Pembelajaran Berbasis Masalah dapat meningkatkan hasil belajar Tematik Siswa Kelas V SD N Kutowinangun 10 Salatiga.
Upaya Meningkatkan Aktivitas dan Hasil Belajar Bahasa Indonesia Melalui Model Pembelajaran Group Investigation dengan Pendekatan Galery
Authors: Gede Mudana I Gusti Agung Made 
Published: April 2019

Penelitian ini dilaksanakan di kelas X.9 SMAN 8 Denpasar dengan tujuan untuk meningkatkan aktivitas dan hasil belajar bahasa Indonesia dengan menggunakan metode pembelajaran Group Investigation melalui pendekatan galery. Menurut Slavin (1995) pembelajaran Group Investigation (GI) adalah pembelajaran yang dilakukan secara berkelompok, siswa dalam satu kelas dijadikan kelompok-kelompok kecil yang terdiri dari 4 sampai 5 orang untuk memahami konsep yang difasilitasi oleh guru. Galery adalah segala sesuatu yang diwujudkan secara visual yang diwujudkan dalam bentuk dua dimensi sebagai curahan perasaan atau fikiran (Hamalik, 1986). Jadi Galery yang dimaksud disini adalah hasil kerja kelompok yang dipajang secara visual dan kelompok lain memberikan input atau pendapat mengenai hasil karya kelompok. Penelitian ini dirancang dalam dua siklus dengan masing-masing siklus terdiri atas tahap perencanaan, pelaksanaan, observasi, evaluasi serta analisis dan refleksi tindakan. Dalam penelitian ini diperoleh informasi bahwa aktivitas belajar siswa tergolong cukup aktif pada siklus I, menjadi tergolong sangat aktif pada siklus II. Hasil belajar siswa tergolong tuntas yaitu dari 68,02 pada siklus I, menjadi 83,02 pada siklus II. Diharapkan kedepan, model pembelajaran ini bisa diterapkan dalam proses pembelajaran pada mata pelajaran yang lain sehingga apa yang menjadi tujuan pendidik yaitu meningkatkan kualitas pendidikan tercapai.
Peningkatan Kompotensi Guru Melalui Pelatihan Membuat RPP Kurikulum 2013 Edisi Revisi dengan Mengaktifkan MGMP Tingkat SMA/K di Kabupaten Bangli
Authors: Wandri I Nyoman 
Published: April 2019

Tujuan dari penelitian untuk meningkatkan Kompotensi guru melalui Pelatihan membuat RPP Kurikulum 2013 edisi revisi Tingkat SMA/K di Kabupaten Bangli. Penelitian ini adalah Penelitian Tindakan Sekolah (PTS) dengan menggunakan rancangan tiga siklus dan masing-masing siklus terdiri dari empat tahapan yaitu: perencanaan – tindakan – observasi – refleksi. Dalam mencapai data hasil penelitian dipergunakan teknik pengukuran berupa tes supaya mendapatkan data kuantitatif. Lembar observasi dipergunakan agar mendapatkan data kualitatif. Kumpulan data dianalisis dengan menggunakan analisis deskriftif. Penelitian ini menggunakan subjek penelitian sebanyak 26 Guru Agama Hindu, pada MGMP tingkat SMA/K di Kabupaten Bangli dengan kreteria kurang sedang dan mampu. Hasil penelitian yang dilaksanakan dalam dua siklus yaitu siklus pertama dan siklus kedua diperoleh hasil sebagai berikut: Pertama; Pada akhir pelaksanaan siklus pertama dan kedua terdapat peningkatan rata-rata hasil kompotensi guru melalui Pelatihan membuat RPP Kurikulum 2013 dari hasil pelatihan sebelumnya sebesar 76,00 menjadi 85,60 setelah dilaksanakan siklus III pada tingkat profesional guru mencapai nilai baik. Kedua; Ternyata peningkatan Kompotensi guru melalui Pelatihan membuat RPP Kurikulum 2013 dengan mengaktifkan MGMP tingkat SMA/K di Kabupaten Bangli tahun 2018 menunjukan hasil yang sangat signifikan dari kondisi awal sebelum mendapat pelatihan dan bermanfaat sebagai pedoman mengajar.
Synopsis and Review: Algebraic Quantum Theory of Consciousness by Elio Conte
Authors: Conte Elio , Norman Rich 
Published: April 2019

Algebraic Quantum Theory of Consciousness
A Solution to the Problem of Quantum Collapse in Systems Having Three Anticommuting Elements
ISBN 978-88-255-1707-1, formato 17 x 24 cm, 112 pagine, 14 euro
Spectroscopy and Conductivity Studies of Polyvinyl Alcohol (PVA)/Polypyrrol (Ppy) Nanocomposite with Various Chloride Metals to Improved Properties of the Polymers
Authors: Shahin Naglaa , Abd El Hamid Reham Kamal 
Published: April 2019

Polyvinyl alcohol- polypyrrole (PVA-PPy) nanocomposites with metal chlorides (FeCl3, NiCl2, CuCl2 and ZnCl2) have been synthesized by chemical oxidative polymerization method. These synthesized nanocomposites are characterized by using FTIR, X-ray diffraction, Transition electron microscope (TEM) and Conductivity measurement. TEM exhibit that all of the composites have uniform sizes and morphologies. The diameter of PVA/PPy nanocompsite is 58nm when the metals added to the PVA/PPy the diameters becomes smaller. The variation of electrical conductivity (log ?) with 1000/T for PVA/PPy nanocomposite with metal chlorides revealed that the increase in conductivity s at temperature (393K) with added metals can be attributed to the creation of induced charge carriers in PVA/PPy matrix
The Power of Interpersonal Communication Skill in Enhancing Service Provision
Authors: Febrianita Roziana , Hardjati Susi 
Published: April 2019

One of interpersonal soft skill is a skill of interpersonal communication; that is the focus of this research. The purpose of this paper are defined in two parts. First, to explore the interpersonal communication skills of the educational staff. Second, to recognize the power of this interpersonal communication. The research of this paper has been studied by means of qualitative method. The approach of this study is a sequences of in-depth interviews with 4 informants of each faculty with A credit for accreditation examination result. This research result finds that there are 3 interpersonal communication skills of educational staff area. Secondly, there are power of the interpersonal communication skill which have made improvement to service providing in the work unit. The results of this research also explain whether maintaining interpersonal relationship enhances the service providing.
Characteristics of Celiac Disease in Childhood of Eastern Algeria
Authors: Abed Nousseiba , Cherouat Nour el houda , Mohammedi Hanane , Rouabah Abdelkader , Rouabah Leila 
Published: April 2019

Abstract
Objective: To determine the symptoms, associated pathologies and features of Childhood Celiac Disease in the population of eastern Algeria.
Study: The retrospective study was conducted in Pediatric Specialized Hospital of Sidi Mabrouk - Constantine. This study was based on data of 100 patients.
Results: In this sample, we noted a diversity of signs and associated pathology, a variety of digestive symptoms represented mainly by abdominal pain (59%), chronic diarrhea (51%) and vomiting (48%). Extra-digestive symptoms represented mainly by palorous skin and mucosa, delayed status and weight and stagnation of the weight with the percentages: 69%, 53% and 51% respectively. In addition, we noted biological disorders and a series associated pathologies namely: anemia (29%) and mouth ulcers (6%).
Conclusion: Childhood Celiac Disease (CD) of eastern Algeria can be expressed by a variety of digestive symptoms and gastrointestinal disorders (GI) in addition to a series of associated conditions.
The Process of Making Tempe Benguk as Tourist Attraction in Kulon Progo Yogyakarta
Authors: Sari Dhanik Puspita 
Published: April 2019

This research discuss the process of making tempe with benguk bean (Mucuna pruriens) as the raw material that can be developed into a form of cultural tourism attractions which aims to improve the income level of the local community in the area of Kulon Progo Regency, Yogyakarta. The used of Benguk Bean based on its originally that only can be found around this region and cannot be treated carelessly due to contain toxic compounds which must be removed. The process and method of cooking is still done in traditional ways, it begin by washing the benguk bean, boiling to fermenting and transform into edible food. The makers still using the traditional stove with firewood or old coconut leaf, bamboo strainer, using ashes, yeast, and banana leaves or teak leaves. This study uses a qualitative study approach. The data used are primary and secondary data collected in several ways including observation, in-depth interviews, documentation and litelature study. This study will focus on the activities done in the process of making tempe benguk as a tourist attraction using Mix activties: the nature of activities in tourism destination.
Analysis of Village Tourism Development in Sawahan, Trenggalek Regency, Indonesia: A Sustainable Livelihood Approach
Authors: Parmawati Rita , Saktiawan Yusup , Wibowo Ferik Antyo Agus , Kurnianto Agung Sih 
Published: April 2019

Sustainable approach takes into consideration five aspects in the development of the model : social, natural, human, physical, and economic. This study aims to find out the Development of Tourism Village Based on Sustainable Livelihood Approach in Sawahan Village, Watulimo Subdistrict, Trenggalek Regency. The study was conducted on July-August, 2017 in Sawahan Village, Watulimo Subdistrict, Trenggalek Regency, East Java Province. The assumption is that the sustainable livelihood process has been running in the village. We observed 5 types of assets: naturalt, human, financial, social, and physical. The results are analyzed qualitatively as well quantitatively by statistical assumptions. We use the parameter significance test, which consists of testing the significance of parameters simultaneously and testing the significance of partial regression model parameters. Natural and social asset become the main factor in supporting the development of sustainable livelihood in Sawahan Village. Although it affects as minor condition, the financial, physical, and human asset can significantly influence when in the same condition.
Key Words : Asset, Livelihood, Sawahan, Sustainable