bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acknowledgment of collective victimization: Findings from four contexts of historical victimization
Authors: Twali Michelle Sinayobye , Eldeeb Sherief Y. , Vollhardt Johanna Ray 
Published: November 2024

AbstractAcknowledgment of collective victimization is often understood as a crucial precursor to promoting victimized groups’ well‐being and breaking the cycle of violence. Yet, research on acknowledgment has focused on a few forms of acknowledgment from the perpetrator group, thus limiting our understanding on what acknowledgment entails and who should engage in it. Furthermore, what is considered to be appropriate acknowledgment may be shaped by the historical and sociopolitical context. To address these issues, we conducted a qualitative online survey that explored how four historical victim groups (Armenian Americans, Black Americans, Jewish Americans, and the Palestinian diaspora, total N = 273) perceive how acknowledgment of their group's collective trauma should look like. Qualitative content analysis revealed four broad theoretical categories of what acknowledgment entails: symbolic gestures, knowledge and education, structural redress, and learning lessons and preventing violence. We also found four categories concerning who should acknowledge the ingroup's trauma: everyone, adversaries, the ingroup, and third parties. Responses varied across groups, suggesting the importance of the sociopolitical context in acknowledgment. The findings extend theoretical and empirical work on acknowledgment and have important program and policy implications.
Virtual exchange as a mode of internationalization at a distance: Experiences from Türkiye
Authors: Çalıkoğlu Alper , Bulut‐Sahin Betül , Aşık Asuman 
Published: November 2024

AbstractThis study examines virtual exchange (VE) as a mode of internationalization at a distance through the Turkish higher education context. Recognizing the constraints of geographical mobility, VE emerges as a viable alternative to enhance international and intercultural learning through technology. Employing a qualitative phenomenological design, we interviewed 22 participants, including students, faculty members and international office professionals from five Turkish universities. Our findings reveal diverse motivations, such as personal and academic development, and highlight professional and intercultural affordances. However, significant challenges persist, including technological limitations, time and communication obstacles and institutional support deficiencies. Our study indicates that VE projects provide valuable international experiences and intercultural awareness for students unable to participate in geographical mobility, yet they require careful consideration of technological tools and planning of activities in the ‘third space’ to overcome existing barriers and enhance student engagement. We recommend that scholars and institutional leaders give more consideration to VE from the viewpoint of internationalization at a distance for more inclusive and equitable internationalization practices in higher education driven by technological tools.
Practitioner notesWhat is already known about this topic?

Virtual exchange offers cost‐effective solutions for international and intercultural exchanges, especially for students with limited opportunities for geographical mobility.
What does this paper add?

Examines the virtual exchange from the viewpoint of Internationalization at a distance, using the Turkish case.
Uses the conceptual lens of space, place and time to understand virtual exchange and Internationalization at a distance and improve virtual exchange experiences in underprivileged contexts.
Implications for policy and practice

Instructors should foster a sense of community and belonging for virtual exchange participants and diversify technological tools and communication mechanisms.
Institutions should prioritize virtual exchange and technology integration in internationalization, provide adequate resources for students and faculty members and incentivize virtual exchange.
Uncharted Territory: Delving into Unexplored Knowledge to Curb Ableism in Academia
Authors: Schippers Alice , Koning Mark , Cardinaal Leo 
Published: November 2024

ABSTRACTIntroductionLanguage can reflect bias: an ‘intellectual’ disability means for many people that you cannot be an academic knowledge producer; a ‘learning’ disability means that your education will be hampered. Like language definitions, academic practices can reflect societal biases. The social (in)justice regarding knowledge and knowledge production is called epistemic injustice, and it has resulted in exclusion of nonconventional knowers, such as persons with intellectual or learning disabilities, from academia and higher education (other than as objects of research).MethodsThis paper will discuss academic practices through the lens of epistemic (in)justice and look at the potential of inclusive research and educational practices therein. We will briefly describe dominant ways of knowing (e.g., abstract, verbal), and counter these practices in exploring practical, tacit, embodied and affective ways of knowing.FindingsFor people with intellectual disabilities to be able to gain recognition as ‘real’ knowers within academia, we need to include diverse types of knowing and enable academic practices to be inclusive of people with intellectual disabilities. Inclusive practices can support a paradigm shift away from dominant ways of knowledge production in research and education, by centralising and correctly interpreting alternate knowledge. Experiences of scholars with intellectual disabilities appear to confirm the value of different ways of knowing.ConclusionsDrawing from these experiences, we will discuss the importance of relational autonomy, collectively owned and adaptive knowledge, and the learning context.
EDITORIAL for BJP themed issue “noncoding RNA therapeutics”
Authors: Devaux Yvan , Zacchigna Serena , Schulz Rainer 
Published: November 2024

LINKED ARTICLESThis article is part of a themed issue Non‐coding RNA Therapeutics. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v182.2/issuetoc
Plasma miR‐1‐3p levels predict severity in hospitalized COVID‐19 patients
Authors: Di Pietro Paola , Abate Angela Carmelita , Izzo Carmine , Toni Anna Laura , Rusciano Maria Rosaria , Folliero Veronica , Dell'Annunziata Federica , Granata Giovanni , Visco Valeria , Motta Benedetta Maria , Campanile Alfonso , Vitale Carolina , Prete Valeria , Gatto Cristina , Scarpati Giuliana , Poggio Paolo , Galasso Gennaro , Pagliano Pasquale , Piazza Ornella , Santulli Gaetano , Franci Gianluigi , Carrizzo Albino , Vecchione Carmine , Ciccarelli Michele 
Published: November 2024

Background and PurposeAccumulating evidence suggests circulating microRNAs (miRNAs) are important regulators of biological processes involved in COVID‐19 complications. We sought to assess whether circulating miRNAs are associated with COVID‐19 clinical phenotype and outcome.Experimental ApproachTo discover signatures of circulating miRNAs associated with COVID‐19 disease severity and mortality, miRNA quantification was performed on plasma samples collected at hospital admission from a cohort of 106 patients with mild or severe COVID‐19. Variable importance projection scoring with partial least squared discriminant analysis and Random Forest Classifier were employed to identify key miRNAs associated with COVID‐19 severity. ROC analysis was performed to detect promising miRNA able to discriminate between mild and severe COVID status.Key ResultsHsa‐miR‐1‐3p was the most promising miRNA in differentiating COVID‐19 patients who developed severe, rather than mild, disease. Hsa‐miR‐1‐3p levels rose with increasing disease severity, and the highest levels were associated with prolonged hospital length of stay and worse survival. Longitudinal miRNA profiling demonstrated that plasma hsa‐miR‐1‐3p expression levels were significantly increased in patients during acute infection compared with those observed 6 months after the disease onset. Specific blockade of miR‐1‐3p in SARS‐CoV‐2–infected endothelial cells decreased up‐regulation of genes involved in endothelial‐to‐mesenchymal transition, inflammation and thrombosis. Furthermore, miR‐1‐3p inhibition reversed the impaired angiogenic capacity induced by plasma from patients with severe COVID‐19.Conclusion and ImplicationsOur data establish a novel role for miR‐1‐3p in the pathogenesis of COVID‐19 infection and provide a strong rationale for its usefulness as early prognostic biomarkers of severity status and survival.
LINC02154 promotes cell cycle and mitochondrial function in oral squamous cell carcinoma
Authors: Niinuma Takeshi , Kitajima Hiroshi , Sato Tatsuya , Ogawa Toshifumi , Ishiguro Kazuya , Kai Masahiro , Yamamoto Eiichiro , Hatanaka Yui , Nojima Iyori , Toyota Mutsumi , Yorozu Akira , Sekiguchi Shohei , Tohse Noritsugu , Furuhashi Masato , Ohguro Hiroshi , Miyazaki Akihiro , Suzuki Hiromu 
Published: November 2024

AbstractLong noncoding RNAs (lncRNAs) play pivotal roles in the development of human malignancies, though their involvement in oral squamous cell carcinoma (OSCC) remains incompletely understood. Using The Cancer Genome Atlas (TCGA) dataset, we analyzed expression of 7840 lncRNAs in primary head and neck squamous cell carcinoma (HNSCC) and found that upregulation of LINC02154 is associated with a poorer prognosis. LINC02154 knockdown in OSCC cell lines induced cell cycle arrest and apoptosis, and significantly attenuated tumor growth in vitro and in vivo. Notably, depletion of LINC02154 downregulated FOXM1, a master regulator of cell cycle‐related genes. RNA pulldown and mass spectrometry analyses identified a series of proteins that could potentially interact with LINC02154, including HNRNPK and LRPPRC. HNRNPK stabilizes FOXM1 expression by interacting with the 3′‐UTR of FOXM1 mRNA, which suggests LINC02154 and HNRNPK promote cell cycling by regulating FOXM1 expression. Additionally, LINC02154 positively regulates HNRNPK expression by inhibiting microRNAs targeting HNRPNK. Moreover, LINC02154 affects mitochondrial function by interacting with LRPPRC. Depletion of LINC02154 suppressed expression of mitochondrial genes, including MTCO1 and MTCO2, and inhibited mitochondrial respiratory function in OSCC cells. These results suggest that LINC02154 exerts its oncogenic effects by modulating the cell cycle and oxidative phosphorylation in OSCC, highlighting LINC02154 as a potential therapeutic target.
Fixed Full‐Arch Maxillary Prostheses Supported by Four Versus Six Implants: 5‐Year Results of a Multicenter Randomized Clinical Trial
Authors: Toia Marco , Moreira Cristiano S. , Dias Debora R. , Corrà Enrico , Ravidà Andrea , Cecchinato Denis 
Published: November 2024

ABSTRACTObjectivesThis 5‐year multicenter randomized clinical trial assessed the non‐inferiority of maxillary implant‐supported fixed complete dentures (FCDs) with four (4‐I) compared to six implants (6‐I) in terms of radiographic marginal bone level (MBL) changes after 5 years in function.Materials and MethodsIndividuals were randomly assigned to the 4‐I or 6‐I groups. Follow‐ups occurred at 1, 3, and 5 years. At each visit, FCDs were unscrewed, clinical parameters (plaque index, bleeding on probing, pocket depth, and keratinized mucosa width) were recorded using a periodontal probe, periapical radiographs were obtained, and maintenance care was performed. MBL changes, incidence of techincal, prosthetic, and biological complications, treatments costs, and satisfaction were evaluated.ResultsOf 47 patients rehabiliated with 233 implants, survival rates were 99.3% for 6‐I and 100% for 4‐I (one early failure; 6‐I group). No significant MBL differences were observed at 5 years between and within the groups. Both groups showed a decrease in keratinized mucosa width and experienced prosthetic and biological complications, but no peri‐implantitis. The 4‐I exhibited a significantly higher incidence of technical complications (16.6% vs. 0%) Cost analysis favored 4‐I for initial and total costs. Clinician and patient satisfaction varied, with 4‐I preferred aesthetically and 6‐I functionally, particularly in speaking ability at earlier follow‐ups.ConclusionThe use of FCDs supported by four implants is non‐inferior to six implants in terms of radiographic MBL changes after 5 years in function. Both groups demonstrated comparable survival rates and incidence of biological and prosthetic complications. The 4‐I was associated with higher technical complications and reduced overall treatment cost.Trial RegistrationClinicalTrials.gov identifier: NCT02405169
The early diagnosis of Alzheimer's disease: Blood‐based panel biomarker discovery by proteomics and metabolomics
Authors: Dong Yun , Song Xun , Wang Xiao , Wang Shaoxiang , He Zhendan 
Published: November 2024

AbstractDiagnosis and prediction of Alzheimer's disease (AD) are increasingly pressing in the early stage of the disease because the biomarker‐targeted therapies may be most effective. Diagnosis of AD largely depends on the clinical symptoms of AD. Currently, cerebrospinal fluid biomarkers and neuroimaging techniques are considered for clinical detection and diagnosis. However, these clinical diagnosis results could provide indications of the middle and/or late stages of AD rather than the early stage, and another limitation is the complexity attached to limited access, cost, and perceived invasiveness. Therefore, the prediction of AD still poses immense challenges, and the development of novel biomarkers is needed for early diagnosis and urgent intervention before the onset of obvious phenotypes of AD. Blood‐based biomarkers may enable earlier diagnose and aid detection and prognosis for AD because various substances in the blood are vulnerable to AD pathophysiology. The application of a systematic biological paradigm based on high‐throughput techniques has demonstrated accurate alterations of molecular levels during AD onset processes, such as protein levels and metabolite levels, which may facilitate the identification of AD at an early stage. Notably, proteomics and metabolomics have been used to identify candidate biomarkers in blood for AD diagnosis. This review summarizes data on potential blood‐based biomarkers identified by proteomics and metabolomics that are closest to clinical implementation and discusses the current challenges and the future work of blood‐based candidates to achieve the aim of early screening for AD. We also provide an overview of early diagnosis, drug target discovery and even promising therapeutic approaches for AD.
High Fish Biomass and Low Nutrient Enrichment Synergistically Enhance Stability in a Seagrass Meta‐Ecosystem
Authors: Hesselbarth Maximilian H. K. , Allgeier Jacob E. 
Published: November 2024

ABSTRACTTropical seagrass ecosystems are globally imperiled due to overfishing and anthropogenic disturbances. Sustaining the services they provide will require managing resilience, particularly with increased volatility from climate change. Portfolio theory is touted as a mechanism to increase resilience in ecosystems because it takes advantage of temporal volatility in local production dynamics to increase stability at larger spatial scales. Using an individual‐based model of a network of artificial reefs across multiple seagrass ecosystems that is parameterized with 15 years of field data, we demonstrate that (1) the large fish populations and the low enrichment synergistically increase portfolio effects; (2) the mechanism was via reduced local and increased meta‐ecosystem stability in primary production; and (3) stability was greatest under intermediate production because nutrient enrichment reduces and fish, which have less influence on the amount of production, promote stability. Integrating common‐sense management with portfolio theory can stabilize the services provided by seagrass ecosystems.
Explanation seeking and anomalous recommendation adherence in human‐to‐human versus human‐to‐artificial intelligence interactions
Authors: Jenkin Tracy , Kelley Stephanie , Ovchinnikov Anton , Ying Cecilia 
Published: November 2024

AbstractThe use of artificial intelligence (AI) in operational decision‐making is growing, but individuals can display algorithm aversion, preventing adherence to AI system recommendations—even when the system outperforms human decision‐makers. Understanding why such algorithm aversion occurs and how to reduce it is important to ensure AI is fully leveraged. While the ability to seek an explanation from an AI may be a promising approach to mitigate this aversion, there is conflicting evidence on their benefits. Based on several behavioral theories, including Bayesian choice, loss aversion, and sunk cost avoidance, we hypothesize that if a recommendation is perceived as an anomalous loss, it will decrease recommendation adherence; however, the effect will be mediated by explanations and differ depending on whether the advisor providing the recommendation and explanation is a human or an AI. We conducted a survey‐based lab experiment set in the online rental market space and found that presenting a recommendation as a loss anomaly significantly reduces adherence compared to presenting it as a gain, however, this negative effect can be dampened if the advisor is an AI. We find explanation‐seeking has a limited impact on adherence, even after considering the influence of the advisor; we discuss the managerial and theoretical implications of these findings.
Exploring Queer Colombian Preservice English Language Teachers' Perceptions Towards Queering English Language Teaching
Authors: Tarrayo Veronico N. , Vásquez‐Guarnizo Jhonatan , Tobar‐Gómez Mairon Felipe 
Published: November 2024

ABSTRACTRecent initiatives have highlighted the need for integrating a gender perspective into English Language teaching (ELT), particularly in Colombia where gender diversity in education lacks significant sociocultural advancement. This study investigates the perceptions of 11 queer preservice English‐language teachers (PSELTs) from a Colombian public university, using semistructured interviews to explore their views on queering ELT and their future roles as educators. The findings emphasise the importance and challenges of adopting a queer perspective in ELT, essential for creating inclusive environments that respect (queer) students' identities. Moreover, the experiences of these PSELTs during their training have empowered and motivated them as future educators to advocate for societal transformation by promoting awareness of gender diversity in Colombian EFL classrooms. This study supports critical educational reforms that recognise and integrate diverse identities, enriching teaching practices and fostering inclusive learning environments.
Outcomes of cerebrovascular disease in muscular dystrophies: A propensity‐matched nationwide analysis
Authors: Al‐Salahat Ali , Dilsaver Danielle B. , Bawaneh Saif , Chen Yu‐Ting 
Published: November 2024

AbstractBackground and purposeThe literature lacks large studies on outcomes of cerebrovascular disease (CVD) in patients with muscular dystrophies (MDs). Previous studies primarily focused on ischemic stroke. CVD can add considerable morbidity in patients with MD. We aimed to study the outcomes of CVD in patients with MDs using a national database.MethodsData were abstracted from the 2010–2021 Nationwide Readmission Database. We identified hospitalizations for CVDs including ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, and other unspecified CVDs. We used propensity‐score matching to account for selection bias and baseline differences between MD and non‐MD patients in type of CVD, age, biological sex, time of discharge, and comorbidity burden. Outcomes were inpatient mortality, 30‐day and 90‐day readmissions, length of stay, costs and discharge disposition.ResultsThere were an estimated 6,129,132 CVD hospitalizations, of which 0.03% (weighted N = 2098) were for patients with MD. Ischemic stroke was the most common type, followed by intracerebral hemorrhage. MD was associated with 41% lower odds of a routine discharge, 9% greater costs, and 30% lower odds of 90‐day all‐cause readmissions. Inpatient mortality was higher in the MD cohort, but the difference was not statistically significant. There were no significant differences in other outcomes.ConclusionThe findings of this study provide new insights into the outcomes of CVD in MD patients, highlighting the need for enhanced access to post‐discharge care in such patients. Improved post‐discharge care may help reduce readmissions and avoid longer hospital stays. This study could be valuable for neurologists, rehabilitation physicians, healthcare administrators and economists.
Efficacy and safety of perampanel in patients with seizures associated with Lennox–Gastaut syndrome: A randomized trial
Authors: Vossler David G. , Porter Brenda E. , Kira Ryutaro , Lee Jeehun , Aeby Alec , Patten Anna , Cheng Jocelyn Y. , Ngo Leock Y. ,   the 338 Study Investigators
Published: November 2024

AbstractObjectivesThe Phase 3 Study 338 (NCT02834793) assessed long‐term clinical outcomes of adjunctive perampanel in patients ≥2 years of age with uncontrolled seizures associated with Lennox–Gastaut syndrome (LGS).MethodsEligible patients were diagnosed with LGS and receiving one to four concomitant antiseizure medications with an average of two or more drop seizures/week during baseline. The study comprised an 18‐week double‐blind, randomized, placebo‐controlled Core Study and ≥52‐week open‐label Extension. The primary endpoint was median percent change in drop seizure frequency per 28 days during the Core Study. Key secondary endpoints included responder rates, seizure‐freedom rates, and safety outcomes. Post hoc analyses were performed encompassing a broader range of drop seizures or all countable motor seizures.ResultsSeventy patients were randomized into the Core Study (perampanel, n = 34; placebo, n = 36), and 58 entered the Extension. In the Core Study, numerically greater median percent reductions in drop seizure frequency were observed with perampanel (23.1%) vs placebo (4.5%) using prespecified assessments (p = .107), whereas significantly greater reductions were detected using the broader definition (48.6% vs −.7%, respectively, p = .001) or all countable motor seizures (44.0% vs −.6%, respectively, p = .017). The 50% responder rate for drop seizures was higher with perampanel vs placebo using modern definitions. Reductions in seizure frequency with perampanel were maintained over 52 weeks. Treatment‐emergent adverse events occurred in 85.3% of perampanel‐treated patients (somnolence [23.5%] was the most frequent) and 72.2% of placebo‐treated patients.SignificanceThis study had a reduced sample size and was underpowered. Although the difference in reductions in drop seizure frequency between treatments was not statistically significant by prespecified assessments, adjunctive perampanel demonstrated sustained efficacy in reducing drop seizures associated with LGS for ≤71 weeks using modern definitions. No new safety signals emerged. These observations suggest the long‐term efficacy and safety of perampanel in the LGS population.