bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel HLA‐A*24 Variant, HLA‐A*24:02:01:144Q, Identified in a Breast Cancer Patient From Brazil
Authors: Stelet Vinícius N. , Silva Christina , Romero Matilde , Binato Renata , Abdelhay Eliana 
Published: November 2024

ABSTRACTIdentification of the novel HLA‐A*24:02:01:144Q allele that differs from HLA‐A*24:02:01:01 at one position in intron 4.
Identification of the Novel HLA‐DPA1*02:146 Allele by PacBio Sequencing
Authors: Chen Bin , An Tongcui , Lin Yani , Ru Kun , Li Chengping 
Published: November 2024

ABSTRACTThe novel HLA‐DPA1*02:146 allele differs from HLA‐DPA1*02:20 by one nucleotide substitution in exon 2.
Characterisation of the Novel HLA‐A*36:15 Allele by Next‐Generation Sequencing and Oxford Nanopore Technology
Authors: de Oliveira Anthony Marçal Leão , Massi Fernanda Pelisson , Pinto Larissa Danielle Bahls , Neto Quirino Alves de Lima , Visentainer Jeane Eliete Laguila 
Published: November 2024

ABSTRACTThe new HLA‐A*36:15 allele differs from A*36:01:01:01 at position −44 in exon 1.
Characterisation of the Novel HLA‐A*23:147 Allele Using New Next‐Generation Sequencing Methods
Authors: Giorno‐Amar Maëlys , Avias Maude , Basire Agnès , Frassati Coralie , Pedini Pascal 
Published: November 2024

ABSTRACTHLA‐A*23:147 differs from HLA‐A*23:13 allele by one nucleotide substitution in codon 283 in exon 5.
The Novel HLA‐A*02:1138 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual
Authors: Ren Juan , Xie Zhicong , Zheng Endong , Zhou Ying , Wang Xiaoning 
Published: November 2024

ABSTRACTHLA‐A*02:1138 differs from HLA‐A*02:03:01:01 by one nucleotide in exon 2.
Climate change, bodies and diplomacy: Performing watery futures in Tuvalu
Authors: Saddington Liam 
Published: November 2024

AbstractClimate change is one of the key foci of critical geopolitics in the twenty‐first century, with a proliferation of scholarship considering the international conferences, imaginaries, and securitisations of the climate crisis. Since 2019, Tuvalu has been using human bodies submerged in water – including diplomats, children, and politicians ‐ within its diplomacy to draw attention to the severity of the climate crisis. By examining contemporary Tuvaluan climate diplomacy, this article advocates for a greater engagement with feminist geopolitics to interrogate the embodied practices of climate diplomacy. It draws upon fieldwork conducted in the South Pacific in 2018 and 2019 including at the 50th Pacific Island Forum in Tuvalu. Firstly, this article explores the 2019 visit of the Secretary General of the United Nations to Tuvalu ‐ arguing the photoshoot of him wearing a formal suit in the lagoon connected the imaginary of Tuvalu as a ‘sinking island’ to a wider international community. Secondly, it considers the use of Tuvaluan schoolchildren playing in the water during the 50th Pacific Island Forum. It argues this constituted a vital territorial conjuncture that drew attention to Australia's inaction on climate change and the risk to Tuvalu's future from the rise of sea level. Thirdly, it considers the body of Simon Kofe, Foreign Minister of Tuvalu, during his addresses to COP26 and COP27 from firstly the lagoon in Funafuti and then the metaverse, to examine the shifting narratives of Tuvalu's future within its climate diplomacy. This article argues that climate diplomacy is a deeply embodied practice and human geography scholarship must be more attentive to the geopolitical work that bodies do within climate diplomacy to understand the temporalities and spatialities of diplomacy better.
Sparsity of stable primes for dynamical sequences
Authors: König Joachim 
Published: November 2024

AbstractWe show that a dynamical sequence of polynomials over a number field whose set of stable primes is of positive density must necessarily have a very restricted, and, in particular, virtually prosolvable dynamical Galois group. Together with existing heuristics, our results suggest, moreover, that a polynomial all of whose iterates are irreducible modulo a positive density subset of the primes must necessarily be a composition of linear functions, monomials, and Dickson polynomials.
Construction of varieties of low codimension with applications to moduli spaces of varieties of general type
Authors: Bangere Purnaprajna , Gallego Francisco Javier , Mukherjee Jayan , Raychaudhury Debaditya 
Published: November 2024

AbstractWe develop a new way of systematically constructing infinitely many families of smooth subvarieties of any given dimension , , and any given codimension in , embedded by complete subcanonical linear series, and, in particular, in the range of Hartshorne's conjecture. We accomplish this by showing the existence of everywhere non‐reduced schemes called ropes, embedded in , and by smoothing them. In the range , we construct smooth subvarieties, embedded by complete subcanonical linear series, that are not complete intersections. We also go beyond a question of Enriques on constructing simple canonical surfaces in projective spaces, and construct simple canonical varieties in all dimensions. The canonical map of infinitely many of these simple canonical varieties is finite birational but not an embedding. Finally, we show the existence of components of moduli spaces of varieties of general type (in all dimensions , ) that are analogues of the moduli space of curves of genus with respect to the behavior of the canonical map and its deformations. In many cases, the general elements of these components are canonically embedded and their codimension is in the range of Hartshorne's conjecture.
Effective upper bounds on the number of resonances in potential scattering
Authors: Cuenin Jean‐Claude 
Published: November 2024

AbstractWe prove upper bounds on the number of resonances and eigenvalues of Schrödinger operators with complex‐valued potentials, where is odd. The novel feature of our upper bounds is that they are effective, in the sense that they only depend on an exponentially weighted norm of V. Our main focus is on potentials in the Lorentz space , but we also obtain new results for compactly supported or pointwise decaying potentials. The main technical innovation, possibly of independent interest, are singular value estimates for Fourier‐extension type operators. The obtained upper bounds not only recover several known results in a unified way, they also provide new bounds for potentials that are not amenable to previous methods.
Dynamic Obstacle Avoidance Strategy for High-Speed Vehicles Via Constrained Model Predictive Control and Improved Artificial Potential Field
Authors: Xu Mingyang , Yue Ming , Gu Yao , Shangguan Jinyong , Zhao Xudong 
Published: November 2024

Abstract
The paper proposes an automatic planning and control strategy to keep the automatic driving high-speed vehicles collision-free based on the improved artificial potential field (APF) and constrained model predictive control (MPC). First, the road potential field satisfying the constraints of vehicle safe driving is constructed according to the driving characteristics of vehicles and road boundary conditions. Focusing on the influence of the speed and direction of the obstacle vehicle on the potential field, the dynamic obstacle vehicle potential field is established. Secondly, the road potential field and the dynamic obstacle vehicle potential field are incorporated into the objective function of the path planning module to establish a real-time path planner. Thirdly, the yaw stability constraints of the vehicle are established, which are added to the QP solver and updated in real-time according to the current vehicle states, so as to establish the constrained MPC controller. In the end, the safety of this planning and control strategy for obstacle avoidance overtaking and the effectiveness of constrained MPC in improving vehicle stability are verified by comparative simulation analysis in multi-obstacle vehicles scenarios.
Data-Driven Tracking Control of a Cushion Robot With Safe Autonomous Motion Considering Human-Machine Interaction Environment
Authors: Sun Ping , Shan Rui , Chang Hongbin , Wang Shuoyu 
Published: November 2024

Abstract
This study proposes a data-driven safety controller with velocity constraints for a cushion robot. We constructed a mathematical description of the human-machine interaction environment by decomposing the generalized input force and coefficient matrix in the dynamic model. We established a new equivalent data model, which considered various human-machine interaction environments using a pseudo-Jacobian matrix. A stochastic configuration network (SCN) estimation method for variations in the human-machine interaction environment was proposed, with hidden layer nodes added at random. We designed a safe autonomous navigation path and proposed a data-driven control method that limited the actual velocity while stabilizing the tracking error system. In addition, the desired motion velocity of the robot was designed. This approach has the advantage of ensuring safety at a specified velocity. We also demonstrated and validated the effectiveness of the proposed data-driven algorithm using simulation-based comparative analysis and an experimental study.
Sequential Versus Concurrent Effects in Combined Stress Solder Joint Reliability
Authors: Okafor Ekene Gabriel , Ruby Collin , Norris Mathew , Leda Andrew , Huitink David Ryan 
Published: November 2024

Abstract
Reliability risk in solder joints has been commonly linked to various failure mechanisms, with electromigration (EM) and fatigue among the prominent drivers. Even though these failure mechanisms often occur simultaneously, typical accelerated tests are based on a single failure mechanism. Consequently, the effect of multiple interacting failure mechanisms is ignored, which may underestimate reliability risk. This common practice has the potential to reduce life prediction accuracy. To address this gap, in this paper, we present an experimental setup that is developed and used to simultaneously evaluate SAC 305 solder joint lifetime under electromigration and fatigue failure mechanisms using sequential and concurrent approaches. The sequential approach involves prestressing the solder joint using a fixed current density and temperature until the test vehicle attains a specified rise in resistance. After that, an isothermal fatigue load was applied at three prescribed temperatures. The data collected enable the estimation of parameters used for reliability prediction. On the other hand, the concurrent case involves the simultaneous application of current density, temperature, and cyclic mechanical load to the solder joint. The correlation of the experiment and complementary numerically simulated strain energy density (SED) resulted in an improved, physic-based reliability model, which has the added benefit of reduced time and cost of data collection, especially during new product development. Unlike the concurrent approach, the sequential approach shows a defect-driven failure mode. The prediction accuracy of the concurrent-based derived characteristic life model compared to that of experiment-derived characteristic life was found to be ±25%.
Nonlinear Dynamic Analysis Framework for Slender Structures Using the Modal Rotation Method
Authors: Shizuno Yoshitaka , Dong Shuonan , Kuzuno Ryo , Okada Taiki , Kawashima Shugo , Makihara Kanjuro , Otsuka Keisuke 
Published: November 2024

Abstract
Owing to their low induced drag, high-aspect-ratio wings are often applied to aircraft, particularly high-altitude long-endurance (HALE) aircraft. An analytical method that considers geometrical nonlinearity is necessary for the analysis of high-aspect-ratio wings as they tend to undergo large deformations. Nonlinear shell/plate or solid finite element methods are widely used for the static analysis of wing strength. However, an increase in the number of elements drastically increases the computational costs owing to the complexity of wing shapes. The modal rotation method (MRM) can avoid this additional expense by analyzing large deformations based on modes and stiffness matrices obtained from any linear or linearized model. However, MRM has only been formulated as a static analysis method. In this study, a novel modal-based dynamic analysis framework, referred to as dynamic MRM (DMRM), is developed to analyze slender cantilever structures. This paper proposes a method to discretize dynamics by capitalizing on the fact that MRM considers geometrical nonlinearity based on deformed shapes. The proposed method targets slender structures with small strains and large displacements and considers geometrical nonlinearity, but not material nonlinearity. Additionally, a formulation method for the work performed by a follower force is proposed. The energy stored in the structure agreed with the work performed by an external force in each performed simulation. DMRM achieved a 95% reduction in the calculation time compared with a nonlinear plate finite element method in a performed simulation.
Accuracy of an Activity Monitor in Assessing Physical Activity of Hospitalized Geriatric Rehabilitation Patients With Slow Walking Speed Using a Walking Aid
Authors: van Dijk Margaretha , Bijnens Wouter , Van Driessche Catoo , Van Meerbeek Toon , Allegaert Patsy , Van Cleynenbreugel Heleen , Verschueren Sabine , Verheyden Geert , Tournoy Jos , Flamaing Johan 
Published: November 2024

Background/Objectives: Accurate assessment of physical activity is essential in hospital settings, but difficult for geriatric rehabilitation patients who have slow walking speed and rely on walking aids. This study conducted an external validation of the MOX activity monitor accuracy in distinguishing between sedentary (lying, sitting), standing, and dynamic activities among hospitalized geriatric rehabilitation patients. Additionally, the study assessed clinical tolerance and ease of use of the monitor. Methods: Inclusion criteria were being hospitalized on the geriatric rehabilitation ward, aged 70 years or older, and using a walking aid. The monitor was placed on the upper leg, and remained in place for 1 week. In a test-session, four activities of 4 min each (lying, sitting, standing, and walking) were filmed. Video analyses created a direct observation timeline. Daily skin irritation assessments were conducted and participants noted their discomfort level at the week’s end. Results: The study included 20 participants who relied on walking aids, with 10 requiring additional physical support while walking. The MOX activity monitor exhibited excellent accuracy in classifying the four activities, with a zero mean percentage error for sedentary activity, 2.2% for standing, and 2.7% for walking. Participants reported minimal hindrance, and the monitor proved user-friendly. Conclusion: The MOX activity monitor demonstrated remarkable accuracy in distinguishing between these four activities in a test-session and displayed strong clinical applicability. Significance: The monitor shows substantial promise as a valuable tool for assessing physical activity in hospitalized geriatric rehabilitation patients using walking aids.
It Has To Be My Way—Reducing Sedentary Time in the Transition to Retirement
Authors: Hultman Lisa , Eklund Caroline , von Heideken Wågert Petra , Söderlund Anne , Elfström Magnus L. 
Published: November 2024

Background: Sedentary behavior is highly prevalent in older adults transitioning to retirement. Sedentary time is all of the time spent in sedentary behavior, and prolonged sedentary time is associated with an increased risk of noncommunicable diseases. The aim of this study was to explore perceptions among older adults transitioning from working life to retirement regarding self-management strategies for reducing sedentary time and adhering to the reduced sedentary time. Methods: Twenty-eight older adults, age 60–75 years, participated in one of four focus group interviews. Qualitative content analysis was used to analyze the data. Results: The analysis resulted in the theme “It has to be my way,” and the three categories “Activities scattered with joyfulness,” “Support for changes in everyday life,” and “Health affects willingness and ability, and is affected by adherence.” Conclusions: Interpreted from the perspective of self-determination theory, self-management strategies for reducing sedentary time should be adaptable as every individual is unique, indicating a need for autonomy. Sedentary time was said to be reduced by activities that evoked joyfulness, and joyfulness was considered to increase adherence. Support for changes to one’s everyday life was considered necessary. The support that was mentioned primarily involved targeting cognitive determinants such as self-efficacy and attitudes. This new knowledge can be included when designing self-management interventions; however, more research is needed in order to evaluate whether self-management strategies targeting autonomous motivation and affective determinants, such as affective judgment and cognitive determinants, can reduce sedentary time in those who are in the transition to retirement.
A Systematic Review of the Effects of Breaking up/Interrupting Sedentary Behavior on Health Outcomes Among Community-Dwelling Adults 60+ Years
Authors: Swartz Ann M. , Steinbrink Garrett M. , Strath Scott J. , Mitra Tarini , Morelli Whitney A. 
Published: November 2024

Background/Objectives: The aim of this systematic review was to evaluate the available evidence regarding the impact of breaks in sedentary time on cardiovascular, metabolic, functional, and psychosocial health of adults aged 60 years and older. Methods: A systematic search of databases was performed in May 2024. This review was registered with PROSPERO (#374311) and has been reported using the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Results: A total of seven articles (five unique studies) were included. The available evidence suggests minimal changes in health-related variables. Specifically, changes to cardio-metabolic and psychosocial variables were limited. Changes to physical function appear to show the most promise. While only one of the studies included focused solely on reducing sedentary behavior, all others focused on reducing sedentary behavior by increasing physical activity. Two of the seven articles showed significant changes compared with the control group to sedentary time ranging from 32 to 58 min. Mean sedentary bout time and number of sedentary bouts longer than 30 min were reduced in two of the seven articles. No changes in sit-to-stand transitions were reported. Conclusion: There is limited evidence focusing on the impact of breaks or interruptions to sedentary time on the physical and mental health of community-dwelling adults 60+ years. Significance/Implications: This systematic review examines recent research aimed to disrupt sedentary behavior and positively impact health in community-dwelling older adults. Results show the difficulty of increasing sit-to-stand transitions/breaks in sedentary behavior, and highlight the challenge of disentangling the effects of sedentary behavior, and physical activity on health.
LDC000067, a CDK9 inhibitor, unveils promising results in suppressing influenza virus infections
in vitro
and
in vivo
Authors: Zhang Mingxin , Lian Xiaoqin , Gao Yarou , Jiang Lefang , Li Zhuogang , Zhang Haonan , Su Yue , Peng Qun , Chen Xulin 
Published: November 2024

ABSTRACT

Influenza virus infections continue to pose a significant threat to public health. Current anti-influenza drugs target viral proteins; however, the emergence of resistant strains has hampered their effectiveness. Fortunately, as with most viruses, influenza virus depends on various host factors during its replication cycle and in pathogenicity. Therefore, the manipulation of key host factors for viral replication to combat influenza has garnered increased attention due to its lesser tendency to induce viral mutation. Cyclin-dependent kinases (CDKs) are a family of protein kinases that regulate various cellular processes, including the cell cycle and transcription. While the specific involvement of CDKs in the transcription of influenza virus genes is less extensively studied than their roles in the cell cycle, some evidence suggests their potential contributions as anti-influenza drugs. Here, we report that LDC000067 (LDC), a highly specific CDK9 inhibitor, not only strongly suppressed influenza virus replication
in vitro
and
in vivo
but also emerged as a potential candidate for anti-influenza virus agents. Further investigation revealed that inhibition of CDK9 by LDC treatment and CDK9 silencing disrupts viral RNA transcription and the nuclear import of vRNPs, significantly suppressing influenza virus replication. Mechanistically, we showed that LDC treatment and CDK9 silencing reduce Pol II expressions, a requisite host protein for viral RNA transcription. Altogether, our findings indicate that CDK9 could be a promising target for developing antivirals against influenza virus infections, and LDC, with its strong anti-influenza properties, instills confidence in its potential as an effective anti-influenza agent.
Microbial communities associated with marine sponges from diverse geographic locations harbor biosynthetic novelty
Authors: Nowak Vincent V. , Hou Peng , Owen Jeremy G. 
Published: November 2024

ABSTRACT

Marine sponges are a prolific source of biologically active small molecules, many of which originate from sponge-associated bacteria. Identifying the producing bacteria is a key step in developing sustainable routes for the production of these metabolites. To facilitate the required computational analyses, we developed MetaSing, a reproducible singularity-based pipeline for assembly, identification of high-quality metagenome-assembled genomes (MAGs), and analysis of biosynthetic gene clusters (BGCs) from metagenomic short-read data. We applied this pipeline to metagenomic sequencing data from 16 marine sponges collected from New Zealand, Tonga, and the Mediterranean Sea. This analysis yielded 643 MAGs representing 510 species. Of the 2,670 BGCs identified across all samples, 70.8% were linked to a MAG. Comparison of BGCs to those identified from previously sequenced bacteria revealed high biosynthetic novelty in variety of underexplored phyla, including Poribacteria, Acidobacteriota, and Dadabacteria. Alongside the observation that each sample contains unique biosynthetic potential, this holds great promise for natural product discovery and for furthering the understanding of different sponge holobionts.

IMPORTANCE
Discovery of new chemical compounds such as natural products is a crucial endeavor to combat the increasing resistance to antibiotics and other drugs. This manuscript demonstrates that microbial communities associated with marine sponges investigated in this work encode the potential to produce novel chemistry. Lesser studied bacterial taxa that are often difficult to cultivate are particularly rich in potential.