bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring integrated accessibility for sustainable mobility: a fuzzy set approach case study
Authors: Tahmasbi Behnam , Hajian Poria , Tahmasbi Farzaneh , He Qian 
Published: November 2024

AbstractSustainable transportation is vital to climate justice and social equity. Despite the efforts to achieve sustainability, there is still a lack of adequate measurement that integrates land use and transportation systems, which can be barriers to planning implementation. With methodological improvements in fuzzy theory application, this study develops an integrated index to measure the sustainability of multimodal accessibility. We do so by defining a fuzziness degree based on the different trip purposes and modes of transportation with a case study in Isfahan, Iran. Sustainable accessibility indicators were developed for walking, biking, and public transportation to represent the performance of each transportation system, considering the integration with land-use patterns. We analyze transportation modes and the accessibility to five main urban activities, including employment opportunities, education, healthcare, shopping, and recreation services, based on the travel distances, followed by a statistical integration method with Principal Components Analysis (PCA) for each travel mode. The outcome provides insights for urban planners and transportation planners to effectively evaluate the degree of integration between transportation and land-use systems and contribute to enhancing sustainable accessibility.
Residents’ willingness to pay for sustainable solid waste management services: a case of Glenview suburb, Harare, Zimbabwe
Authors: Jerie Steven , Chireshe Amato , Shabani Tapiwa , Shabani Takunda 
Published: November 2024

AbstractSolid waste generation is an inevitable outcome of anthropogenic activities, which is an issue of concern in Zimbabwe. Among other challenges, inadequate finance is a key challenge to reach sustainable waste management. This study focuses on residents’ willingness to pay for improved solid waste management services. Analytical case study research design, employing quantitative and qualitative data collection, analysis and presentation was adopted. Data was collected using questionnaires, interviews, observations while analysis was done using SPSS and content analysis. Results indicated that most respondents were house owners (53.92%) and 46.08% were tenants. Solid waste generated consists of hazardous and non-hazardous waste. Solid waste collected by the city council (57.84%), private collectors (36.27%) while remaining is collected by other individuals and scavengers. Interviews and questionnaires outcomes denote that solid waste was collected once a week (43.14%), twice a week (3.92%) and rarely collected (38.24%). Solid waste is disposed through open dumping, burning, pits and landfilling, although most of the disposal strategies pose environmental health problems. Solid waste mismanagement is attributed to lack of awareness, weak legal framework and shortage of resources, specifically finance. Questionnaire respondents (66.67%) argued that proper solid waste management is important and needs to be improved. Participants (65.69%) revealed that they were willing to pay for improved solid waste management, however, 34.31% were unwilling. Willingness to pay for improved solid waste management was determined by educational level and house ownership status. Improving residents’ willingness to pay for proper solid waste management requires an integrated approach and increasing residents' awareness.
Monthly Prediction on Summer Extreme Precipitation With a Deep Learning Approach: Experiments Over the Mid‐To‐Lower Reaches of the Yangtze River
Authors: Fan Yi , Lyu Yang , Zhu Shoupeng , Yin Zhicong , Duan Mingkeng , Zhi Xiefei , Zhou Botao 
Published: November 2024

AbstractAccurate predictions of monthly extremes assume paramount importance in enabling proactive decision‐making, which however are lacked in skills even for state‐of‐the‐art dynamical models. Taking the extreme precipitation prediction over the mid‐to‐lower reaches of the Yangtze River, China, as an instance, a multi‐predictor U‐Net deep learning approach is designed to enhance the prediction over the European Center for Medium‐Range Weather Forecasts (ECMWF) model, with the single‐predictor U‐Net parallelly examined as the benchmark. Focusing on the precipitation extremes, an extreme associated component is incorporated into the model loss function for optimization. Besides, predictions composed by daily outputs with multiple lead times are imported as a comprehensive set in the training phase to augment the deep learning sample size and to emphasize enhancements in predictions at the monthly timescale as a whole. Results indicate that the multi‐predictor U‐Net effectively improves predictions of extreme summer precipitation frequency, showing distinct superiority to the raw ECMWF and the single‐predictor U‐Net. Multiple evaluation metrics indicate that the model shows a significant positive improvement ratio ranging from 65.1% to 80.0% across all grids compared to the raw ECMWF prediction, which has also been validated through applications in the two extreme summer precipitation cases in 2016 and 2020. Besides, a ranking analysis of feature importance reveals that factors such as humidity and temperature play even more crucial roles than precipitation itself in the multi‐predictor extreme precipitation prediction model at the monthly timescale. That is, in such a deep learning approach, the monthly prediction on extreme precipitation benefits significantly from the inclusion of multiple associated predictors.
Dynamically Triggered Tectonic Tremors and Earthquakes in the Caucasian Region Following the 2023 Kahramanmaraş, Türkiye, Earthquake Sequence
Authors: Yao Dongdong , Peng Zhigang , Ding Chang , Sandvol Eric , Godoladze Tea , Yetirmishli Gurban 
Published: November 2024

AbstractDeep tectonic tremor has been observed along major subduction zones and several continental strike‐slip faults around the Pacific Rim and the Caribbean. However, it has not be widely identified in other tectonically active regions such as the Alpine‐Himalayan orogenic belt yet. Here we present dynamically triggered tremors and microearthquakes in the Caucasian Region following the 2023 Mw 7.8 and Mw 7.5 mainshocks in the 2023 Kahramanmaraş, Türkiye, earthquake sequence. We observe triggered deep tectonic tremors within Azerbaijan, where seismological evidences suggest pre‐existing subduction slabs. Meanwhile, we document cases of triggered earthquakes in Azerbaijan and Georgia, and Javakheti highland near the border of Georgia and Armenia. These triggered earthquakes are either associated with mud volcanism or volcanic formations. Our results highlight a variety of responses to dynamic stress perturbations, suggesting high susceptibility to dynamic stress perturbations and a broad spectrum of slip behaviors for critically stressed faults in the Caucasian region.
On the Relationship Between the Banded Hiss Distribution and Plasmapause Location: A Survey of Van Allen Probes Observations
Authors: Dong Junhu , Xiang Zheng , Ni Binbin 
Published: November 2024

AbstractThe plasmapause is the outer boundary of the plasmasphere and plays a crucial role in the propagation of plasma waves. We statistically investigate the relationship between the distribution of banded hiss and plasmapause locations. Wave power distributions of banded hiss are analyzed in terms of two ways: (a) the distance away from the plasmapause (ΔL) and (b) the equatorial distance away from the Earth. Statistical results show both bands of banded hiss have larger wave powers and occurrence rates near the plasmapause. The frequencies of two banded hiss waves both decrease discernably with increasing L‐shell at most magnetic local time sectors and geomagnetic activities, but remain nearly constant with increasing ΔL. The highly consistent distribution suggests both bands may be generated in the plume region. The correlation between banded hiss waves and plasmapause locations sheds new light on the generation mechanisms of banded hiss waves.
Possible Causes for the Unprecedented Low/High Tropical Cyclone Activities in the Northern Pacific/Atlantic in 2023 El Niño
Authors: Chen Kuan‐Chieh , Hong Chi‐Cherng , Chang Chi‐Chun , Chiang Jun , Chang Sheng‐Hsiang 
Published: November 2024

AbstractThis study reported the unprecedented tropical cyclone (TC) activity in the western North Pacific (WNP) and North Atlantic (NA) during the developing year of the 2023/2024 El Niño. The possible causes behind these unusual features were addressed. In contrast to previous El Niño events, an unusual low/high TC genesis number in the WNP/NA was identified during the typhoon season (June–November) in 2023. Meanwhile, the mean TC genesis location in the WNP exhibited a La Niña‐like northwestward shift, rarely observed in an El Niño developing year. An observational diagnosis on TC‐genesis‐related large‐scale dynamics and thermodynamics revealed that the lower/higher TC numbers in the WNP/NA were primarily attributed to an anticyclonic/cyclonic anomaly linked to trans‐basin sea surface temperature anomalies in the tropics and extratropics. Additionally, weaker intraseasonal oscillation activity compared to previous El Niños also partially contributed to fewer TCs in the WNP.
Investigating the “Too Bright” Issue Pertaining to Non‐PBL Clouds Over the South Pacific Trade‐Wind Region in CMIP6 Global Climate Models
Authors: Li J.‐L. F. , Xu Kuan‐Man , Jiang Jonathan H. , Lee Wei‐Liang , Yu Jia‐Yuh , Chern Jiun‐dar , Cesana Gregory V. , Wu Longtao , Stephens Graeme 
Published: November 2024

AbstractThis paper examines the “too bright” issue pertaining to non‐planetary boundary layer (PBL) clouds over the South Pacific trade‐wind region and its potential link to the falling ice radiative effects (FIREs). We run sensitivity experiments with CESM2‐CAM6 (CESM2) global climate model with FIREs on (SON) and off (NOS). The model exhibits more in‐cloud liquid water content (CLWC) and droplet above the PBL in NOS, leading to larger shortwave (SW) reflectivity at the top of the atmosphere than in SON over the trade wind regions. CMIP6 models are divided into three subsets: separately calculates the radiative effects of cloud ice and falling ice (SON2), combined (SON1) and without falling ice (NOS). SON2 models exhibit improved CLWC and SW reflectivity similar to CESM2‐SON, while NOS and SON1 models are akin to CESM2‐NOS owing to weaker surface wind stress and warmer ocean surface, caused by the lack of FIREs over the convective zones.
New Late Cretaceous Paleomagnetic Results From the Eastern Qiangtang Terrane: Implications for the Postcollisional Extrusion and Convergence of the Southeastern Tibetan Plateau
Authors: Ma Jiahui , Yang Tianshui , Han Fei , Liang Jiacheng , Jiao Xianwei , Wang Suo , Bian Weiwei , Ma Yiming , Zhang Shihong , Wu Huaichun , Li Haiyan 
Published: November 2024

AbstractTo refine the postcollisional extrusion and convergence history of the southeastern Tibetan Plateau, we report a quality paleomagnetic data set from Upper Cretaceous redbeds of the eastern Qiangtang Terrane (QT), where is situated at the front edge of eastern Himalayan Syntaxis. The 32 site‐mean directions provide a mean pole at 75.4°N, 176.8°E (A95 = 2.4°) and a paleolatitude of 31.8 ± 2.4°N for the Mangkang area. Comparison with reliable Late Cretaceous paleomagnetic data from the eastern QT and East Asia indicates that the eastern QT experienced a southward extrusion of 940 ± 310 km after the Late Cretaceous. Comparing Late Cretaceous paleolatitudes estimated from the eastern QT and Lhasa terrane (LT) reveals a paleolatitude difference of 2,390 ± 620 km. Such a great latitudinal convergence can be attributed to the fact that some continental terranes originally located between the eastern LT and QT were laterally extruded after the Late Cretaceous.
Research progress on aero-optical effects of hypersonic optical window with film cooling
Authors: Yi Shihe , Ding Haolin , Luo Suyiming , Sun Xiaobin , Xia Zihao 
Published: November 2024

AbstractIn recent years, the demand for optical imaging and detection in hypersonic aircraft has been on the rise. The high-temperature and high-pressure compressed flow field near airborne optoelectronic devices creates significant interference with light transmission, known as hypersonic aero-optical effects. This effect has emerged as a key technological challenge, limiting hypersonic optical imaging and detection capabilities. This article focuses on introducing the thermal effects and optical transmission effects of hypersonic aero-optical effects, as along with corresponding suppression techniques. In addition, this article critically reviews and succinctly summarizes the advancements made in hypersonic aero-optical effects testing technology, while also delineating avenues for future research needs in this field. In conclusion, there is an urgent call for further exploration into the study of aero-optical effects under conditions characterized by high Mach, high enthalpy, and high Reynolds number in the future.
2D4, a humanized monoclonal antibody targeting CD132, is a promising treatment for systemic lupus erythematosus
Authors: Yin Huiqi , Li Liming , Feng Xiwei , Wang Zijun , Zheng Meiling , Zhao Junpeng , Fan Xinyu , Wu Wei , Gao Lingyu , Zhan Yijing , Zhao Ming , Lu Qianjin 
Published: November 2024

AbstractCurrent therapies for systemic lupus erythematosus that target a particular factor or cell type exhibit limited effectiveness. To address this limitation, our focus was on CD132, a subunit common to six inflammatory factor receptors implicated in SLE. Our study revealed heightened CD132 expression in SLE patients’ lymphocytes, contributing to the production of pro-inflammatory cytokines and immunoglobulins. We developed a novel humanized anti-CD132 monoclonal antibody, named as 2D4. 2D4 efficiently blocked IL-21 and IL-15, with limited effectiveness against IL-2, thereby suppressing T and B cells without disrupting immune tolerance. In the mouse immunization model, 2D4 virtually inhibited T cell-dependent, antigen-specific B-cell response. In lupus murine models, 2D4 mitigated inflammation by suppressing multiple pro-inflammatory cytokines and anti-dsDNA antibody titers, also diminishing proteinuria and glomerulonephritis. Compared to Belimumab, 2D4 exhibited superior efficacy in ameliorating the inflammatory state and preserving renal function. Moreover, 2D4 exhibited the ability to inhibit the production of pro-inflammatory factors and autoantibodies in PBMCs from individuals with SLE, highlighting its therapeutic potential for SLE individuals. Potent, 2D4 has the potential to significantly improve clinical outcomes in SLE and other complex autoimmune disorders.
ADAMTS16 drives epithelial-mesenchymal transition and metastasis through a feedback loop upon TGF-β1 activation in lung adenocarcinoma
Authors: Xiao Lingyan , Li Qian , Chen Shuaijun , Huang Yongbiao , Ma Li , Wang Yuan , Chen Junjie , Zhang Jun , Liu Andong , Yuan Xianglin , Liu Yuanhui , Liu Bo 
Published: November 2024

AbstractLung adenocarcinoma (LUAD) is the major subtype of lung cancer. The poor prognosis of LUAD patients is attributed primarily to metastasis. ADAMTS16 is a crucial member of the ADAMTS family and is involved in tumor progression. However, its role and regulatory mechanism in LUAD remain unexplored. In this study, ADAMTS16 was identified as a crucial oncogene and survival predictor in LUAD via analyses of public datasets. Clinical specimens and tissue microarrays confirmed the differential expression and prognostic value of ADAMTS16 in LUAD patients. Transcriptome data and in vitro experiments demonstrated that ADAMTS16 was positively associated with epithelial-mesenchymal transition (EMT) and the migration abilities of LUAD cells. Knockdown of ADAMTS16 attenuated lung and pleural metastasis in an animal model. Mechanistically, the results of the enzyme-linked immunosorbent assay (ELISA) and western blot (WB) suggested that ADAMTS16 activated the TGF-β signaling pathway by facilitating the conversion of LAP-TGF-β1 to active TGF-β1. Co-Immunoprecipitation (co-IP) indicated an interaction between ADAMTS16 and LAP-TGF-β1. Inhibition of ADAMTS16 impaired EMT and aggressiveness of LUAD cells, while treatment with recombinant TGF-β1 reversed this inhibition. Chromatin immunoprecipitation (ChIP) and dual-luciferase reporter assays indicated that SOX4 acted as a transcriptional activator of ADAMTS16 and that TGF-β1 regulated the expression of ADAMTS16 by increasing the binding of SOX4 to the promoter of ADAMTS16. Suppressing the TGF-β signaling pathway inhibited ADAMTS16 expression, EMT, and lung metastasis, whereas overexpressing SOX4 reversed this inhibition. Therefore, ADAMTS16 forms a positive feedback loop with the TGF-β1/SOX4 axis to regulate EMT and metastasis, and disruption of this feedback loop inhibits tumor progression. These findings underscore the potential of ADAMTS16 as a prognostic biomarker and therapeutic target in LUAD and offer novel insight into the mechanism of EMT and metastasis.
TSG101 depletion dysregulates mitochondria and PML NBs, triggering MAD2-overexpressing interphase cell death (MOID) through AIFM1-PML-DAXX pathway
Authors: Xi Yao , Xu Rui , Chen Shengnan , Fang Jiezhu , Duan Xiang , Zhang Yidan , Zhong Guoli , He Zhifei , Guo Yan , Li Xinyu , Tao Wenzhi , Li Yang , Li Yan , Fang Lei , Niikura Yohei 
Published: November 2024

AbstractOverexpression of mitotic arrest deficiency 2 (MAD2/MAD2L1), a pivotal component of the spindle assembly checkpoint (SAC), resulted in many types of cancer. Here we show that the depletion of tumor susceptibility gene 101 (TSG101), causes synthetic dosage lethality (SDL) in MAD2-overexpressing cells, and we term this cell death MAD2-overexpressing interphase cell death (MOID). The induction of MOID depends on PML and DAXX mediating mitochondrial AIFM1-release. MAD2, TSG101, and AIF-PML-DAXX axis regulate mitochondria, PML nuclear bodies (NBs), and autophagy with close inter-dependent protein stability in survival cells. Loss of C-terminal phosphorylation(s) of TSG101 and closed (C-)MAD2-overexpression contribute to induce MOID. In survival cells, both MAD2 and TSG101 localize at PML NBs in interphase, and TSG101 Y390 phosphorylation is required for localization of TSG101 to PML NBs. PML release from PML NBs through PML deSUMOylation contributes to induce MOID. The post-transcriptional/translational cell death machinery and the non-canonical transcriptional regulation are intricately linked to MOID, and ER-MAM, may serve as a crucial intersection for MOID signaling.
Therapeutic advances in the targeting of ROR1 in hematological cancers
Authors: Tigu Adrian-Bogdan , Munteanu Raluca , Moldovan Cristian , Rares Drula , Kegyes David , Tomai Radu , Moisoiu Vlad , Ghiaur Gabriel , Tomuleasa Ciprian , Einsele Hermann , Gulei Diana , Croce Carlo M. 
Published: November 2024

AbstractReceptor tyrosine kinases (RTKs) are key cell surface receptors involved in cell communication and signal transduction, with great importance in cell growth, differentiation, survival, and metabolism. Dysregulation of RTKs, such as EGFR, VEGFR, HER2 or ROR, could lead to various diseases, particularly cancers. ROR1 has emerged as a promising target in hematological malignancies. The development of ROR1 targeted therapies is continuously growing leading to remarkable novel therapeutical approaches using mAbs, antibody-drug conjugates, several small molecules or CAR T cells which have shown encouraging preclinical results. In the hematological field, mAbs, small molecules, BiTEs or CAR T cell therapies displayed promising outcomes with the clinical trials data encouraging the use of anti-ROR1 therapies. This paper aims to offer a comprehensive analysis of the current landscape of ROR1-targeted therapies in hematological malignancies marking the innovative approaches with promising preclinical and clinical. Offering a better understanding of structural and functional aspects of ROR1 could lead to new perspectives in targeting a wide spectrum of malignancies.
DDX3 is critical for female fertility via translational control in oogenesis
Authors: Tsai Shang-Yu , Lin Chih-Hung , Jiang Yu-Ting , Huang Guo-Jen , Pi Haiwei , Hung Hsin-Yuan , Tarn Woan-Yuh , Lai Ming-Chih 
Published: November 2024

AbstractDEAD-box RNA helicase 3 (DDX3) and its homologs play a vital role in translation initiation by unwinding secondary structures of selected mRNAs. The human DDX3 gene is located on the sex chromosomes, so there are DDX3X and DDX3Y. DDX3X is ubiquitously expressed in almost all tissues and critical for embryonic development, whereas DDX3Y is only expressed in the testis and essential for male fertility. Drosophila belle (bel) is the single ortholog of DDX3, and mutations in bel cause male and female infertility. Using Drosophila bel mutants and Ddx3x conditional knockout (cKO) mice, we confirmed the pivotal role of DDX3 in female fertility and ovarian development. Drosophila bel mutants exhibited female infertility and immature egg chambers. Consistently, oocyte-specific Ddx3x knockout in mice resulted in female infertility and impaired oogenesis. We further found that immature egg chambers in Drosophila bel mutants and impaired follicular development in oocyte-specific Ddx3x cKO mice were caused by excessive apoptosis. We also identified a set of DDX3 target genes involved in oocyte meiosis and maturation and demonstrated that DDX3 is involved in their translation in human cells. Our results suggest that DDX3 is critical for female fertility via translational control in oogenesis.
Soluble αβ-tubulins reversibly sequester TTC5 to regulate tubulin mRNA decay
Authors: Batiuk Alina , Höpfler Markus , Almeida Ana C. , Teoh En-Jie Deryn , Vadas Oscar , Vartholomaiou Evangelia , Hegde Ramanujan S. , Lin Zhewang , Gasic Ivana 
Published: November 2024

AbstractMicrotubules, built from heterodimers of α- and β-tubulins, control cell shape, mediate intracellular transport, and power cell division. The concentration of αβ-tubulins is tightly controlled through a posttranscriptional mechanism involving selective and regulated degradation of tubulin-encoding mRNAs. Degradation is initiated by TTC5, which recognizes tubulin-synthesizing ribosomes and recruits downstream effectors to trigger mRNA deadenylation. Here, we investigate how cells regulate TTC5 activity. Biochemical and structural proteomic approaches reveal that under normal conditions, soluble αβ-tubulins bind to and sequester TTC5, preventing it from engaging nascent tubulins at translating ribosomes. We identify the flexible C-terminal tail of TTC5 as a molecular switch, toggling between soluble αβ-tubulin-bound and nascent tubulin-bound states. Loss of sequestration by soluble αβ-tubulins constitutively activates TTC5, leading to diminished tubulin mRNA levels and compromised microtubule-dependent chromosome segregation during cell division. Our findings provide a paradigm for how cells regulate the activity of a specificity factor to adapt posttranscriptional regulation of gene expression to cellular needs.