bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Expression Profile, Regulatory Mechanism and Correlation with Egg-laying Performance of ACSF Gene Family in Chicken (Gallus gallus)
Authors: Tian Weihua , Zheng Hang , Yang Liyu , Li Hong , Tian Yadong , Wang Yanbin , Lyu Shijie , Brockmann Gudrun A. , Kang Xiangtao , Liu Xiaojun 
Published: May 2018

AbstractAcyl-CoA synthetases (ACSs) are responsible for acyl-CoA synthesis from nonpolar hydrophilic fatty acids and play a vital role in many metabolic processes. As a category of ACS isozymes, members of ACS family (ACSF1-3) participate in lipid metabolism; however, their expression patterns, regulatory mechanisms and effects on egg-laying performance in chicken are poorly understood. Our in vivo and in vitro studies showed that ACSF1-3 genes were extensively expressed, and their expression levels changed dynamically in the liver among different development stages. Moreover, ACSF1 expression was upregulated and ACSF2 expression was downregulated by estrogen, but ACSF3 showed no response to estrogen treatment. The regulatory effect of estrogen on ACSF1 expression was mediated via ERα. The ACSF2 was highly expressed in the liver in peak-laying hens compared with pre-laying and late-laying hens, and also highly expressed in the liver continued egg-laying hens compared with inactive egg-laying hens. It is suggested that hepatic ACSF2 expression level might relate to egg-laying performance in chicken. In conclusion, the expression of ACSF1 was upregulated by estrogen via ERα, and the expression of ACSF2 was downregulated by estrogen and might be related to egg-laying performance in chicken.
Digital compensation of the sideband-rejection ratio in a fully analog 2SB sub-millimeter receiver
Authors: Rodriguez R. , Finger R. , Mena F. P. , Alvear A. , Fuentes R. , Khudchenko A. , Hesper R. , Baryshev A. M. , Reyes N. , Bronfman L. 
Published: May 2018

Context. In observational radio astronomy, sideband-separating receivers are preferred, particularly under high atmospheric noise, which is usually the case in the sub-millimeter range. However, obtaining a good rejection ratio between the two sidebands is difficult since, unavoidably, imbalances in the different analog components appear.
Aims. We describe a method to correct these imbalances without making any change in the analog part of the sideband-separating receiver, specifically, keeping the intermediate-frequency (IF) hybrid in place. This opens the possibility of implementing the method in any existing receiver.
Methods. (i) We have built hardware to demonstrate the validity of the method and tested it on a fully analog receiver operating between 600 and 720 GHz. (ii) We have tested the stability of calibration and performance versus time and after full resets of the receiver. (iii) We have performed an error analysis to compare the digital compensation in two configurations of analog receivers, with and without intermediate-frequency hybrid.
Results. (i) An average compensated sideband-rejection ratio of 46 dB is obtained. (ii) Degradation of the compensated sideband rejection ratio on time and after several resets of the receiver is minimal. (iii) A receiver with an IF hybrid is more robust to systematic errors. Moreover, we have shown that the intrinsic random errors in calibration have the same impact for configuration without IF hybrid and for a configuration with IF hybrid with analog rejection ratio better than 10 dB.
Conclusions. We demonstrate that compensated rejection ratios above 40 dB are obtained even in the presence of high analog rejection. Further, we demonstrate that the method is robust allowing its use under normal operational conditions at any telescope. We also demonstrate that a full analog receiver is more robust against systematic errors. Finally, the error bars associated with the compensated rejection ratio are almost independent of whether IF hybrid is present or not.
Assessment of the effects rejections of feed fish on water resources.: (Ouedoumerrbia, Morocco)
Authors: Ouaissa Khadija , Kritihi Assia , Oumessoud Youness , Maychal Abdelaziz , Hasnaoui Mustapha 
Published: May 2018

In order to compare the effects of three types of extruded food (A, B and C) on the growth of rainbow trout, an experimental test was conducted on June 15, 2015 at a rainbow trout farming station near river of Oumerrrabi .Morocco.The comparison of three foods of different composition and energy is performed in isoenergetic conditions.Six basins were used for this comparative test. These basins are fed with fresh water according to the open circuit with a renewal of twice an hour. The initial feeding conditions were the same for the three food types and the initial density of 1, 58 kg/m3(kg by volume) and an initial flow rate of 1, 04 m3/h.Fish are fed by ratios two to three times a day depending on the magnification stage.The sampling frequency is fortnightly, where we measure the zootechnical performance of fish and collect water samples for physicochemical analyses in order to assess the quality of the water leaving in the basins before their discharge into the river of Oum Er-Rbia.The comparative trial of three fish foods (A, B, and C) revealed that diet B is the better formulation reflected by the zootechnical performances and low phosphate release than diet A and C.
Public services for distribution of drinking water and liquid sanitation in urban zones in Morocco Relevance of introduction the performance indicators for preservation water resources.
Authors: Habib AKKA , Abdelhamid BOUZIDI , Said HOUSNI 
Published: May 2018

Because of the absence of regulations and specific national norms, the unilaterally applied indicators for performance evaluation of water distribution management services are insufficient. This does not pave the way for a clear visibility of water resources. The indicators are also so heterogeneous that they are not in equilibrium with the applied management patterns. In fact:
1- The performance (yield and Linear loss index) of drinking water networks presents a discrepancy between operators and lack of homogeneity in terms of parameters put in its equation. Hence, It these indicators lose efficiency and reliability;
2- Liquid sanitation service has to go beyond the quantitative evaluation target in order to consider the qualitative aspects of water.
To reach this aim, a reasonable enlargement of performance indicators is of paramount importance in order to better manage water resource which is becoming scarce and insufficient.
Energy Dispersive X-ray technique applied to fatigue fracture surfaces oxidation to provide information on growth rate
Authors: Hernandez Iñigo , Saunders Edward A. , Madariaga Iñaki 
Published: May 2018

Gas turbine components are strongly affected by cyclic loading during operation, which makes fatigue development the most significant cause of failure or cracking within them. The nature and growth rate of that fatigue is dependent on the stress experienced at a particular area of a part, the temperature, the material properties and the applied loading frequency. Various techniques, such as striation and/or band counting can, in some cases, provide information on fatigue life. However, often such techniques are rendered useless by lack of formation or obliteration by damage and/or oxidation of such features. Once a crack has initiated and is exposed to the engine atmosphere, the level of oxidation and other contaminant elements observed on the crack surface will evolve with time, and, correspondingly, crack depth. Element distribution analysis by an Energy Dispersive x-ray Spectroscopy (EDS) technique applied along a fatigue fracture surface could help to understand the evolution of the crack with time.
Using EDS, an experimental procedure was carried out to ascertain a perceived measured percentage of oxygen plus other additional chemical species at a large number of stations along the length of a fatigue crack. The analysis was performed from the initiation site to the end of the propagation area, and also within the final rupture zone which had less time exposed to air and gasses compared to the fatigue system. An exercise of comparison between that progression in oxidation across cracked in-service components versus perceived measured oxidation level analyses on trial fracture surfaces exposed in atmospheric oven conditions at high temperatures for a number of different durations was performed. The obtained results provided information on specific questions concerning the fatigue propagation life of the in-service components; thereby amplifying the use of the EDS technique in this aspect of the materials forensic field.
Recognition accuracy of tumor extent using a prototype 3D endoscope for superficial gastric tumor: an ex vivo crossover study
Authors: Nomura Kosuke , Kaise Mitsuru , Kikuchi Daisuke , Iizuka Toshiro , Fukuma Yumiko , Kuribayashi Yasutaka , Tanaka Masami , Toba Takahito , Furuhata Tsukasa , Yamashita Satoshi , Matsui Akira , Mitani Toshifumi , Hoteya Shu 
Published: May 2018

Abstract
Background and study aims Many studies have shown the utility of rigid three-dimensional (3 D) endoscopes in surgery, but few have reported the utility of flexible 3 D endoscopes. This ex vivo study was intended to investigate whether a newly developed 3 D endoscope (GIF-Y0083; Olympus) improves diagnostic accuracy for superficial gastric tumor.
Methods Twelve observers comprising experts, trainees, and novices (4 each) evaluated 2 D and 3 D images of 20 specimens resected by gastric ESD. Evaluation items were diagnostic accuracy of tumor extent and degree of confidence in assessing (a) tumor extent, (b) morphology, and (c) comprehensive recognition. The 2 D and 3 D endoscopy data were compared in a crossover analysis.
Results Overall, diagnostic accuracy was significantly higher with 3 D images (88.1 %) than with 2 D images (84.2 %) (P < 0.01). Comparison by skill level showed that 3 D images significantly improved diagnostic accuracy among novices but not among experts or trainees. Comparison by morphology showed that diagnostic accuracy did not differ significantly for type IIa/IIb lesions but improved significantly for type IIc lesions among trainees and novices. Overall, 3 D images significantly increased the degree of confidence in the assessment of all three items (a – c). Comparison by skill level showed similar results, and comparison by morphology showed that regardless of skill level, the degree of confidence in assessing all items (a – c) increased significantly only when examining type IIc lesions.
Conclusion Compared with 2 D images, 3 D images significantly improved both diagnostic accuracy of tumor extent and degree of confidence for diagnosing superficial gastric tumor. The utility of the 3 D endoscope was apparent among trainees and novices and for the diagnosis of type IIc lesions.
Diagnostic yield and predictive factors of findings in small-bowel capsule endoscopy in the setting of iron-deficiency anemia
Authors: Olano Carolina , Pazos Ximena , Avendaño Karla , Calleri Alfonso , Ketzoian Carlos 
Published: May 2018

Abstract
Introduction Despite the widespread use of small-bowel capsule endoscopy (CE), there is still limited data on its utility and effectiveness for the diagnosis and management of patients with iron-deficiency anemia (IDA).
Aim To assess the diagnostic yield of CE and the factors predicting positive findings in patients with IDA.
Methods Patients with unexplained IDA and negative upper and lower endoscopy were included. A positive diagnostic yield was considered when CE diagnosed one or more lesions that could explain the IDA. Sex, age, NSAID consumption, blood transfusion requirement, and ferritin and hemoglobin levels were recorded.
Results In total, 120 CE were included (mean age 58.5 years; F/M 82:38). Mean hemoglobin levels were 9 g/dL and mean ferritin levels were 15.7 ng/mL. Positive findings were present in 50 % of patients. The most frequent was angiodysplasia (45 %). Despite several baseline variables being significantly associated with positive findings, using a logistic regression model, it was verified that male sex (OR 3.93; 95 %CI 1.57 – 9.86), age (OR 1.03; 95 %CI 1.00 – 1.06), and hemoglobin levels (OR 0.73; 95 %CI 0.57 – 0.94) were the variables having an independent effect on the probability of obtaining positive findings. Age older than 50 years (OR 14.05; 95 %CI 1.69 – 116.23) and male sex (OR 3.63; 95 %CI 1.29 – 10.17) were the variables which increased the risk of diagnosing angiodysplasia.
Conclusions CE is a useful technique in patients with IDA. To improve its yield, it is necessary to select patients carefully. Male sex, older age, and low hemoglobin levels were associated with a risk of positive finding in this group of patients. The risk of diagnosing angiodysplasia increased with male sex and older age.
Outcomes of repeat balloon assisted enteroscopy in small-bowel bleeding
Authors: Al-Bawardy Badr , Piovezani Ramos Guilherme , Lennon Ryan , Gorospe Emmanuel , Wong Kee Song Louis , Bruining David , Alexander Jeffrey , Coelho-Prabhu Nayantara , Fidler Jeff , Rajan Elizabeth 
Published: May 2018

Abstract
Background/aims The rate of recurrent small-bowel bleeding (SBB) remains high despite the advent of balloon assisted enteroscopy (BAE). The study aims were to determine: (1) the diagnostic and therapeutic yields, and adverse event rate of repeat BAE in SBB, and (2) the predictors of a positive repeat BAE.
Methods A retrospective review of a BAE database was conducted. Patients who had > 1 BAE for SBB were included. Primary outcomes were diagnostic yield, therapeutic yield, and adverse events of repeat BAE. Secondary outcomes were predictors of a positive repeat BAE.
Results A total of 175 patients (55 % men; mean age 64.1 ± 16.3 years) were included. The diagnostic and therapeutic yields of repeat BAE were 55 % and 42 %, respectively. Repeat BAE adverse events occurred in 5 % with self-limited abdominal pain being most common. Patients with a positive repeat BAE were significantly older than the negative group (68.6 ± 13.9 vs. 60.9 ± 17.1; P = 0.001) and were more likely to have cardiac comorbidities (OR 2.4, 95 %CI: 1.3 – 4.6; P = 0.01), chronic kidney disease (OR 2.3, 95 %CI: 1.1 – 4.9; P = 0.04), chronic obstructive pulmonary disease (OR 3.3, 95 %CI: 1.3 – 8.1; P = 0.01), positive initial BAE (OR 3.6, 95 %CI: 1.9 – 6.8; P < 0.001), and antegrade procedure (OR 3.3, 95 %CI: 1.7 – 6.1; P < 0.001). On multivariate analysis, a positive initial BAE and antegrade route were the only significant predictive factors.
Conclusions Performing a repeat BAE for SBB appears safe and provided modest yields. A positive initial BAE and antegrade route were predictive of a positive repeat BAE.
Access to the Ischium: A Simple Extension of the Posterior Approach in Revision Hip Arthroplasty
Authors: Rueckl Kilian , Boettner Friedrich 
Published: May 2018

AbstractReconstruction of acetabular defects in revision total hip arthroplasty (THA) requires excellent exposure. Most extensile approaches to the acetabulum were described in the trauma literature and are not beneficial for revision THA. This article describes a modification of the standard posterior surgical approach to improve visualization of the ischium as required for acetabular defect reconstruction, insertion of standard and custom triflange cages as well as posterior column plating. The current surgical technique utilizes an intermuscular plane between the gemellus inferior muscle and the obturator externus muscle. This intermuscular plane leads the surgeon directly to the ischium and facilitates easy extension toward the insertion of the hamstring muscles without compromising the insertion of the external rotator muscles along the ischium. This article describes a novel surgical approach to the posterior column and ischium under special consideration of the sciatic nerve, superior gluteal vessels, and medial femoral circumflex artery. This simple extension of the standard posterior approach optimizes exposure of the posterior column during revision THA using a posterior approach.
Neonatal Alexander Disease: Novel GFAP Mutation and Comparison to Previously Published Cases
Authors: Knuutinen Oula , Kousi Maria , Suo-Palosaari Maria , Moilanen Jukka , Tuominen Hannu , Vainionpää Leena , Joensuu Tarja , Anttonen Anna-Kaisa , Uusimaa Johanna , Lehesjoki Anna-Elina , Vieira Päivi 
Published: May 2018

AbstractAlexander disease (AxD) is a genetic leukodystrophy caused by GFAP mutations leading to astrocyte dysfunction. Neonatal AxD is a rare phenotype with onset in the first month of life. The proband, belonging to a large pedigree with dominantly inherited benign familial neonatal epilepsy (BFNE), had a phenotype distinct from the rest of the family, with hypotonia and macrocephaly in addition to drug-resistant neonatal seizures. The patient deteriorated and passed away at 6 weeks of age. The pathological and neuroimaging data were consistent with the diagnosis of AxD. Genetic analysis of the proband identified a novel de novo GFAP missense mutation and a KCNQ2 splice site mutation segregating with the BFNE phenotype in the family. The GFAP mutation was located in the coil 2B region of GFAP protein, similar to most neonatal-onset AxD cases with an early death. The clinical and neuroradiological features of the previously published neonatal AxD patients are presented. This study further supports the classification of neonatal-onset AxD as a distinct phenotype based on the age of onset.
A Rare Case of Spontaneous Mitral Leaflet Perforation Leading to Severe Mitral Regurgitation
Authors: Ari Ashok , Lalitha Nemani 
Published: May 2018

AbstractSpontaneous mitral leaflet perforations are rare. We are reporting a 60 year old hypertensive female patient admitted with pulmonary edema with clinically short systolic murmur at apex without ischemic changes on ECG. There is no h/o chest pain, fever, blunt trauma of chest. TTE no RWMA, good bi- ventricular function, a posteriorly directed eccentric moderate – severe mitral regurgitation, normal LA, LV, no vegetation or prolapsed. TEE after stabilization showed whole in body of AML at its midpoint leading to severe regurgitant jet in to LA with Vena contracta of 0.8 mm. All the papillary muscles were intact and there is no prolapse of leaflets and no vegetation. Cardiac catheterization revealed increased LVEDP and PCWP with mild PAH with normal coronary arteries.
Outcomes of Coronary Angioplasty in Diabetic Patients – A Retrospective Study
Authors: Kishore Galla , Susmitha Chandragiri , Rao P 
Published: May 2018

AbstractAims: We want to study the effect of diabetes Mellitus (DM) on the outcomes in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) comparing those with non diabetics, with reference to gender.Methods: We retrospectively evaluated the consecutive patients undergoing PCI either with acute coronary syndrome (ACS) or chronic stable angina (CSA) in our institute between March 2014 to March 2015. We followed them up to one year for the major cardiovascular events (MACES) and other complications. We compared the rate of events between diabetic and non diabetic patients along with gender subgroups and tested for the significance.Results: In 645 patients undergone PCI in our institute, 326(50.5%) were diabetics, of them 104(31.9%) were females. Patients with diabetes with CAD were older with more incidence of hypertension and kidney derangement than non diabetics. History of CAD and previous procedure are definitely more in diabetics as is multi vessel disease (p=0.02) and LV dysfunction (p=0.003). Total number of patients presenting with complications within one year of PCI is 18(0.02%). Of them 14 are males and 4 are females, 14 were diabetics and 4 were non diabetics. There was no statistical significance in the outcomes between female & males (p=0.7), diabetics females & diabetic males (p=0.48) and non diabetics females & nondiabetic males(p=0.7). Male patients with diabetes had significantly more complications than non diabetic males (p=0.05) but there is no significant difference between diabetic and non diabetic females (p=0.59).Conclusion: Patients with DM undergoing PCI had more complications than non diabetics with significant difference between male diabetics and non diabetic males. This difference is not significant between diabetic and non diabetic females.
WCC 2016-112: A case of varied presentation of thrombus
Authors: Kiran Ravi 
Published: May 2018

AbstractAntiphospholipid syndrome is a well defined entity that is characterized by spontaneous abortion, thrombocytopenia, and recurrent arterial and venous thromboses. A right atrial thrombus mimicking myxoma with pulmonary thromboembolism in a patient with secondary antiphospholipid syndrome is rare.Herein, we describe the case of a 35 year old woman who was admitted to the hospital with shortness of breath, swelling of both lower limbs. Transthoracic and transesophageal echocardiography showed a right atrial mass suggestive of myxoma, and the patient subsequently underwent surgery. A histologic examination of the mass showed myxoma. In our patient, the preoperative investigations could not differentiate the thrombus from a myxoma, and she was operated in outside hospital. Later she presented with deep vein thrombosis and pulmonary thromboembolism to our hospital and was diagnosed as having secondary antiphospolipid syndrome and the review sides of the right atrial mass showed thrombus. Intracardiac thrombus has been rarely reported as a compication of antiphospholipid syndrome.
Case report: In December 2015, a 35 year old woman was admitted to the hospital with swelling of both lower limbs since 15 days, shortness of breath since 15 days. She had a past history of acute left upper limb ischemia in 15/4/2013 for which catheter directed thrombolysis of brachial artery was done with steptokinase, coronary angiogram showed normal coronaries. History of cervical TB lymphadenitis for which she used ATT for 9 months in 2013. History of excision of right atrial myxoma was done on 3/11/15 at outside hospital. Histologic examination showed myxoma. Patient has pallor and bilateral pedal odema on general examination. At admission vitals were stable and systemic examination was normal except for raised jugular venous pressure. ECG showed T inversions in leads V 3-6, II, III, aVF. 2D ECHO showed dilated RA/RV severe TR, moderate PAH, RVSP 50 mm of Hg, TAPSE 1.3, good LV function, mild RV dysfunction, mobile thrombus at the junction of middle hepatic vein & IVC. CTPA showed saddle thrombus in PA extending into RPA, multiple collaterals in anterior & posterior chest wall with non visualisation of part of left subclavian vein.