bluuebunny/crossref_metadata_2025_split huggingface dataset:
Failure of Monoiodoacetate to Induce Lameness in Dogs
Authors: Stobie D. , Greer Nancy , Lipowitz A. J. 
Published: March 2018

SummaryIntra-articular sodium monoiodoace-tate (MIA) has been shown to consistently induce a reproducible model of chronic arthritis in rats, chickens, guinea pigs, rabbits and horses. The purpose of this study was to determine if intra-articular injections of MIA would produce clinical signs of degenerative joint disease in dogs.Two different doses of MIA were injected into the stifle joints of normal dogs. Changes in limb function were evaluated by physical examination and force platform gait analysis. The dogs were evaluated weekly for three weeks, after which the MIA injections were repeated. They were again evaluated weekly for an additional two weeks.Significant changes in limb function were not found during any portion of the study as determined by physical examination of the injected joints and force platform gait analysis. Intra-articular MIA, at the doses used in this study, did not induce lameness nor clinical signs of degenerative joint disease.This study evaluated the potential of intra-articular injections of sodium monoiodoacetate (MIA) to produce degenerative joint disease in dogs. Changes in the injected joints and limb function were evaluated by physical examination and force platform gait analysis. Intraarticular MIA at the doses used in this study did not induce lameness nor clinical signs of degenerative joint disease in dogs.
Internal Fixation with a Veterinary Cuttable Plate in Small Animals
Authors: Brüse Sabine , Dee J. , Prieur W. D. 
Published: March 2018

Summary63 cases (42 cats, 21 dogs) were treated with a newly developed plate that can be cut during surgery to the required length and may be sandwiched if one plate is not rigid enough. The plate is manufactured in lengths of 30 cm and in two different thicknesses, 1.0 mm and 1.5 mm. The thinner plate is used with 1.5 mm or 2.0 mm Cortex screws and the thicker one with 2.0 or 2.7 mm Cortex screws. Healing was generally uneventful with the exceptions noted.
Arthrodesis of the Distal Two Tarsal Joints in the Horse Using Perforated Stainless Steel Cylinders and Cancellous Bone Graft
Authors: Archer R. M. , Schneider R. K. 
Published: March 2018

SummaryTwo perforated stainless steel cylinders and autogenous cancellous bone were implanted into each of the distal intertarsal and tarsometatarsal joints of seven horses. In two control horses holes were drilled into each joint and autogenous cancellous bone was implanted without stainless steel cylinders. Horses which had cylinders implanted in the distal tarsal joints exhibited less lameness and were more comfortable following surgery than were the control horses. Fracture of the third tarsal, central tarsal, or third metatarsal occurred in five of the seven horses implanted with stainless steel cylinders within 45 days of surgery. Two implanted horses and two control horses were observed for five months after surgery. Partial fusion of the distal tarsal joints occurred in all four horses. Control horses were more lame than the implanted horses and developed a large bony exostosis over the medial distal tarsus.
Complications of Canine Tibial Tuberosity Avulsion Fractures
Authors: Johnson K. A. , Goldsmid Sarah 
Published: March 2018

SummarySeventeen dogs between three and 22 months of age were treated for avulsion fractures of the tibial tuberosity. The majority of dogs were greyhounds and bull terriers. Three cases had bilateral involvement. Eleven were treated surgically, four were treated conservatively and two were euthanatised. Lameness was resolved by the time of the last examination in 4/4 conservatively managed cases and 7/11 surgically treated cases. Postoperative complications were related to fracture fixation or growth abnormalities. Fixation complications included avulsion of the tuberosity from the implant, wire breakage, bending of a pin, mild patella luxation and a pin through the tibial plateau growth plate. Deformity of the proximal tibial plateau occurred in two dogs, and flattening of the tibial tuberosity with distal translocation developed in at least two other dogs.
Repair of a Salter IV Physeal Fracture of the Humeral Condyle in a Chow-Chow Using a Cannulated Screw
Authors: Elkins A. D. , Oakes M. G. , Lewis D. D. 
Published: March 2018

SummaryA Salter IV physeal fracture of the humeral condyle in a three-month-old Chow-Chow was repaired using a cannulated screw to provide interfragmentary compression. The fracture was reduced and a Kirschner wire was placed at the level of the olecranon fossa. The AO/ASIF cannulated screw system facilitated screw placement directly over the Kirschner wire, and thus allowed the screw to be placed proximal to the distal humeral growth plate without interfering with elbow extension. Limb and elbow function were normal when the dog was examined eight weeks following surgery. Radiographic union of the fracture had occurred without complication.
Botulinumtoxin A bei der Migräne
Authors: Jost W. H. 
Published: March 2018

ZusammenfassungOnabotulinumtoxin ist seit 2011 zur Therapie der chronischen Migräne zugelassen. Die Therapie hat sich bewährt und ist mittlerweile etabliert. Keine andere Therapie hat bei der chronischen Migräne eine Überlegenheit zeigen können. Die Zulassung orientiert sich an den PREEMPT-Zulassungsstudien und gibt Injektionsstellen und Dosierung vor. Weitere Untersuchungen sind notwendig, damit das Injektionsschema optimiert werden kann. Die Zulassung und die positiven Studiendaten beschränken sich auf die chronische Migräne.
Zerebralparesen und Botulinumtoxin
Authors: Berweck S. , Heinen F , Schroeder A. S. 
Published: March 2018

ZusammenfassungSeit dem Erscheinen der interdisziplinären deutschen und europäischen Konsensus zum Thema Botulinumtoxin (BoNT) für Kinder mit Zerebraparese (CP) hat sich das fächerübergreifende, integrative Behandlungskonzept zur Förderung der motorischen Entwicklung zusehends etabliert. Neben der kondensierten tabellarischen Darstellung und Aktualisierung der Evidenz zu den wichtigsten Aspekten der Therapie, wurde 2009 eine grafische Darstellung der Therapieoptionen (Therapiekurven CP-Motorik) eingeführt. Diese grafische Darstellung der Therapieoptionen für die Förderung der motorischen Fertigkeiten bei Kindern mit CP ermöglicht eine strukturierte Beratung zu den Therapieoptionen und hat im Alltag seine Anwendertauglichkeit im Dialog mit den Familien bewiesen.Insbesondere bei drei der zehn Domänen aus den Konsensus zur Behandlung mit BoNT haben sich neue Erkenntnisse ergeben: “therapeutische Anwendung/Versorgungsqualität”, “Sicherheit”, “Effekte der Botulinumtoxintherapie im Muskel”. Dieser Beitrag aus der Neuropädiatrie soll diese Punkte aus der klinischen Anwenderperspektive überprüfen und aus dem Blickwinkel der neu gewonnenen Erkenntnisse beleuchten.
Therapieoption mit Botulinumtoxin für Patienten mit Parkinson
Authors: Messner M. , Ceballos-Baumann A. , Fietzek U. M. 
Published: March 2018

ZusammenfassungIm Schatten der anderen Therapieoptionen bei Parkinson-Syndromen hat sich die Injektion von Botulinumtoxin für eine Reihe von Indikationen zum unverzichtbaren Helfer gemacht. Hierzu gehören vor allem die Sialorrhoe des Parkinson-Patienten und therapierefraktäre Dystonien des Gesichtes (Blepharospasmus) sowie der Extremitäten (Off-Dystonien). Der Beitrag nennt die Indikation, die verfügbare Evidenz und eine pragmatische Herangehensweise. Die Empfehlung der Autoren zu jeder Indikation sowie deren Zulassungsstatus wird benannt.
Digital Mammography: A World without Film?
Authors: Jirotka M. , Simpson A. C. , Highnam R. P. , Gavaghan D. J. , Watson D. , Brady J. M. , Lloyd S. 
Published: March 2018

Summary

Objectives:
eDiaMoND is a next generation Internet (”Grid”) multidisciplinary research project funded by the UK e-Science Programme with the following objectives; the development of a next generation Internet enabled prototype to demonstrate the potential benefits of a national infrastructure to support digital mammography; the exploration of potential benefits for digital mammography systems, with particular emphasis being placed on selected applications, namely, screening, training, computer-aided detection and appropriate support for epidemiological studies.

Methods:
EDiaMoND has worked in conjunction with selected clinical partners to enable the collection of valuable mammography information and the design of applications based upon extensive requirements gathering exercises. The clinical partners validated both the immediate needs and assisted with defining future needs of such an architecture to support the UK Health Service.

Results:
The project has succeeded in invoking the interest of clinical partners and representatives of the UK NHS Breast Screening Programme in our vision of a world without film, albeit a long way off. The project has also succeeded in identifying the barriers to adopting this approach with the current limitations within the NHS, and has developed a blueprint for working towards this strategy.

Conclusions:
A UK national digital mammography archive has the potential to provide major benefits for the UK. For example, such an archive could: ensure that previous mammograms are always available, and could link up seamlessly the screening, assessment and symptomatic clinics; it could provide a huge teaching and training resource; it could be a huge resource for epidemiological studies.
GEMSS: Privacy and Security for a Medical Grid
Authors: Herveg J. A. M. , Crazzolara F. , Marvin D. , Poullet Y. , Middleton S. E. 
Published: March 2018

Summary

Objectives:
The GEMSS project is developing a secure Grid infrastructure through which six medical simulations services can be invoked. We examine the legal and security framework within which GEMSS operates.

Methods:
We provide a legal qualification to the operations performed upon patient data, in view of EU directive 95/46, when using medical applications on the GEMSS Grid. We identify appropriate measures to ensure security and describe the legal rationale behind our choice of security technology.

Results:
Our legal analysis demonstrates there must be an identified controller (typically a hospital) of patient data. The controller must then choose a processor (in this context a Grid service provider) that provides sufficient guarantees with respect to the security of their technical and organizational data processing procedures. These guarantees must ensure a level of security appropriate to the risks, with due regard to the state of the art and the cost of their implementation.Our security solutions are based on a public key infrastructure (PKI), transport level security and end-to-end security mechanisms in line with the web service (WS Security, WS Trust and SecureConversation) security specifications.

Conclusion:
The GEMSS infrastructure ensures a degree of protection of patient data that is appropriate for the health care sector, and is in line with the European directives. We hope that GEMSS will become synonymous with high security data processing, providing a framework by which GEMSS service providers can provide the security guarantees required by hospitals with regard to the processing of patient data.
Empowering Humanitarian Medical Development Using Grid Technology
Authors: Gonzales J. , Pomel S. , Clot B. , Gutknecht J. L. , Irthum B. , Legré Y. , Breton V. 
Published: March 2018

Summary

Background:
The training of local clinicians is the best way to raise the standard of medical knowledge in developing countries. This requires transferring skills, techniques and resources.

Objectives:
Grid technology opens new perspectives for preparation and follow-up of medical missions in developing countries as well as support to local medical centers in terms of teleconsulting, telediagnosis and patient follow-up. Indeed, grids allow to hide the complexity of handling distributed data in such a way that physicians will be able to access patient data while ignoring where these data are stored.

Methods:
To meet requirements of a development project of the French NPO Chain of Hope in China, we propose to deploy a grid-based federation of databases.

First Results and Conclusions:
A first protocol was established for describing the patients’ pathologies and their pre- and post-surgery states through a web interface in a language-independent way. This protocol was evaluated by French and Chinese clinicians during medical missions in the fall of 2003. The first sets of medical patients recorded in the databases will be used to evaluate grid implementation of services.
Modeling and Designing a Proteomics Application on PROTEUS
Authors: Cuda G. , Veltri P. , Cannataro M. 
Published: March 2018

Summary

Objectives:
Biomedical applications, such as analysis and management of mass spectrometry proteomics experiments, involve heterogeneous platforms and knowledge, massive data sets, and complex algorithms. Main requirements of such applications are semantic modeling of the experiments and data analysis, as well as high performance computational platforms. In this paper we propose a software platform allowing to model and execute biomedical applications on the Grid.

Methods:
Computational Grids offer the required computational power, whereas ontologies and workflow help to face the heterogeneity of biomedical applications. In this paper we propose the use of domain ontologies and workflow techniques for modeling biomedical applications, whereas Grid middleware is responsible for high performance execution. As a case study, the modeling of a proteomics experiment is discussed.

Results:
The main result is the design and first use of PROTEUS, a Grid-based problem-solving environment for biomedical and bioinformatics applications.

Conclusion:
To manage the complexity of biomedical experiments, ontologies help to model applications and to identify appropriate data and algorithms, workflow techniques allow to combine the elements of such applications in a systematic way. Finally, translation of workflow into execution plans allows the exploitation of the computational power of Grids. Along this direction, in this paper we present PROTEUS discussing a real case study in the proteomics domain.
Libraries of Strategies and Ontology-driven Subject Area Models as “Corner Stones” in Grid Development
Authors: Joutchkov A. , Yanovsky A. , Golitsin S. , Arnautov S. , Strizh I. , Tverdokhlebov N. 
Published: March 2018

SummarySeries of experiments of Grid-based calculations by Monte-Carlo simulation of molecular conformations have shown that there are classes of problems that could be “gridified” in short time with reasonable efforts. That could awake serious interest in the Grid from the biophysics and biochemistry community. Experiments with scientific problems that include both intensive computations and intensive data interchange have shown that libraries of strategies could provide an effective tool to adapt Grid-node infrastructure to problem structure. Libraries of strategies on different levels of Grid hierarchy – from local clusters to regional segments – could provide an effective usage of Grid resources.Ontologies provide a universal tool to link distributed databases. Besides, ontologies also allow for the formal construction of models of subject areas. These models are the tools to formalize information requests and to construct intellectual queries to information space. There should be a multi-level hierarchy of ontologies and a critical mass of low-level ontologies must be reached in order to build a knowledge space for a subject area.
The First Grid for the Oral and Maxillofacial Region and Its Application for Speech Analysis
Authors: Akiyama T. , Tamagawa H. , Kato S. , Mizuno-Matsumoto Y. , Nakagawa M. , Maeda Y. , Shimojo S. , Nozaki K. 
Published: March 2018

Summary

Objectives:
Introduction of a new grid-based method for analyzing speech functions which takes into account the related information of patients’ data and the oral air flow with pronouncing analyzed by computational fluid dynamics.

Methods:
An on-line speech analyzer was developed for clinical use utilizing GridPort2.3.1 based on glo-bus2.4.2, comprising several computational tools such as unified data storage, semantic data analysis, computational fluid dynamics analysis and three-dimensional visualization of calculated results from different hardware sources with various types of operation systems.

Results:
The power transportation layer between dental clinics and computational and storage resources could be provided by using a WWW-based portal. The back-end data management system could be constructed using a storage resource broker (SRB) and extensible mark up language (XML).

Conclusions:
The new method allows the construction of a data warehouse through this grid-based speech function analysis in order to extract the principal factors related to speech disorders.
An OGSA-based Integration of Life-scientific Resources for Drug Discovery
Authors: Tohsato Y. , Date S. , Matsuda H. , Shimojo S. , Kosaka T. 
Published: March 2018

Summary

Objectives:
The rapid progress of life-scientific research has the potential to dramatically change the paradigm of drug discovery. Efficient utilization of life-scientific resources, i.e., databases and analytic software tools, poses a challenging issue with regard to the reduction of time and cost in the drug discovery process. In this paper, a variety of heterogeneous Web-based life-scientific resources are integrated toward the improvement of drug discovery performance.

Methods:
For the integration of heterogeneous life-scientific resources, a database federation technique based on three-layer architecture has been utilized. With the federation technique, life-scientific resources are integrated step by step through database layers, database integration layers and analysis layers to encapsulate complexity and heterogeneity. In this study, we have taken advantage of the latest Grid technology based on OGSA (Open Grid Services Architecture) for the implementation of our approach.

Results:
The actual case of life-scientific resources for drug discovery demonstrates that our prototype system developed with the proposed technique works well for the identification process of candidate compounds to a target protein. In other words, the prototype system allows a researcher to retrieve candidate compounds with less effort than before.

Conclusions:
The usefulness of the prototypic system represents the ability of our approach to integrate heterogeneous life-scientific resources, which have the potential to dramatically improve efficiency in drug discovery, resulting in the shortening of drug development. On the other hand, the system requires further consideration from the aspect of practical use. Dynamic aggregation of the resources is one example of such a consideration.
Behavioral Interventions and the Role of Television in the Growing Epidemic of Adolescent Obesity
Authors: Thiagarajah K. , Fleming-Moran M. 
Published: March 2018

Summary

Objective:
To test television exposure’s contribution to overweight (BMI> 95th percentile /age) status in 11.3% of 2001 YRBS respondents, when controlling for moderate/vigorous activity, and eating habits.

Methods:
Controlling for age, ethnicity, smoking, moderate/vigorous activity, and diet habits, gender-specific SUDAAN models estimate likelihood (O.R.) for overweight in teens watching 2+ hours of TV/day.

Results:
TV exposure independently increases odds of overweight by 50% for both genders (boys: OR 1.5 [1.2-1.8]; girls: OR 1.6 [1.2-2.0]), when other covariates are controlled. Low vigorous activity rate (1.39 [1.1-1.86]) and smoking independently promote obesity in girls, while boys with fewer fruit/ vegetable servings are less likely to be overweight (.76 [.60-.96]).

Conclusion:
Current school-based interventions promote environmental and curricular changes for healthier diets and increased activity rates. TV exposure, however, is rarely targeted as a separate risk factor, and requires attention at the individual, family, and community levels.
A Generic Concept for Large-scale Microarray Analysis Dedicated to Medical Diagnostics
Authors: Weninger F. , Merk S. , Kohlmann A. , Haferlach T. , Dugas M. 
Published: March 2018

Summary

Background:
The development of diagnostic procedures based on microarray analysis confronts the bioinformatician and the biomedical researcher with a variety of challenges. Microarrays generate a huge amount of data. There are many, not yet clearly defined, data processing steps and many clinical response variables which may not match gene expression patterns.

Objectives:
To design a generic concept for large-scale microarray experiments dedicated to medical diagnostics; to create a system capable of handling several 1000 microarrays per analysis and more than 100 clinical response variables; to design a standardized workflow for quality control, data calibration, identification of differentially expressed genes and estimation of classification accuracy; and to provide a user-friendly interface for clinical researchers with respect to biomedical interpretation.

Methods:
We designed a database structure suitable for the storage of microarray data and analysis results. We applied statistical procedures to identify differential genes and developed a technique to estimate classification accuracy of gene patterns with confidence intervals.

Results:
We implemented a Gene Analysis Management System (GAMS) based on this concept, using MySQL for data storage, R/Bioconductor for analysis and PHP for a web-based front-end for the exploration of microarray data and analysis results. This system was utilized with large data sets from several medical disciplines, mainly from oncology (~ 2000 micro-arrays).

Conclusions:
A systematic approach is necessary for the analysis of microarray experiments in a medical diagnostics setting to get comprehensible results. Due to the complexity of the analysis, data processing (by bioinformaticians) and interactive exploration of results (by biomedical experts) should be separated.
Estimating the Number of Clusters in DNA Microarray Data
Authors: Azuaje F. , Bolshakova N. 
Published: March 2018

Summary

Objectives:
The main objective of the research is an application of the clustering and cluster validity methods to estimate the number of clusters in cancer tumor datasets. A weighed voting technique is going to be used to improve the prediction of the number of clusters based on different data mining techniques. These tools may be used for the identification of new tumour classes using DNA microarray datasets. This estimation approach may perform a useful tool to support biological and biomedical knowledge discovery.

Methods:
Three clustering and two validation algorithms were applied to two cancer tumor datasets. Recent studies confirm that there is no universal pattern recognition and clustering model to predict molecular profiles across different datasets. Thus, it is useful not to rely on one single clustering or validation method, but to apply a variety of approaches. Therefore, combination of these methods may be successfully used for the estimation of the number of clusters.

Results:
The methods implemented in this research may contribute to the validation of clustering results and the estimation of the number of clusters. The results show that this estimation approach may represent an effective tool to support biomedical knowledge discovery and healthcare applications.

Conclusion:
The methods implemented in this research may be successfully used for the estimation of the number of clusters. The methods implemented in this research may contribute to the validation of clustering results and the estimation of the number of clusters. These tools may be used for the identification of new tumour classes using gene expression profiles.