bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultra-fast accurate reconstruction of spiking activity from calcium imaging data
Authors: Rahmati Vahid , Kirmse Knut , Holthoff Knut , Kiebel Stefan J. 
Published: February 2018

Calcium imaging provides an indirect observation of the underlying neural dynamics and enables the functional analysis of neuronal populations. However, the recorded fluorescence traces are temporally smeared, thus making the reconstruction of exact spiking activity challenging. Most of the established methods to tackle this issue are limited in dealing with issues such as the variability in the kinetics of fluorescence transients, fast processing of long-term data, high firing rates, and measurement noise. We propose a novel, heuristic reconstruction method to overcome these limitations. By using both synthetic and experimental data, we demonstrate the four main features of this method: 1) it accurately reconstructs both isolated spikes and within-burst spikes, and the spike count per fluorescence transient, from a given noisy fluorescence trace; 2) it performs the reconstruction of a trace extracted from 1,000,000 frames in less than 2 s; 3) it adapts to transients with different rise and decay kinetics or amplitudes, both within and across single neurons; and 4) it has only one key parameter, which we will show can be set in a nearly automatic way to an approximately optimal value. Furthermore, we demonstrate the ability of the method to effectively correct for fast and rather complex, slowly varying drifts as frequently observed in in vivo data. NEW & NOTEWORTHY Reconstruction of spiking activities from calcium imaging data remains challenging. Most of the established reconstruction methods not only have limitations in adapting to systematic variations in the data and fast processing of large amounts of data, but their results also depend on the user’s experience. To overcome these limitations, we present a novel, heuristic model-free-type method that enables an ultra-fast, accurate, near-automatic reconstruction from data recorded under a wide range of experimental conditions.
Device Thrombosis After Percutaneous Left Atrial Appendage Occlusion Is Related to Patient and Procedural Characteristics but Not to Duration of Postimplantation Dual Antiplatelet Therapy
Authors: Pracon Radoslaw , Bangalore Sripal , Dzielinska Zofia , Konka Marek , Kepka Cezary , Kruk Mariusz , Kaczmarska-Dyrda Edyta , Petryka-Mazurkiewicz Joanna , Bujak Sebastian , Solecki Mateusz , Pskit Agnieszka , Dabrowska Agnieszka , Sieradzki Bartosz , Plonski Andrzej , Ruzyllo Witold , Witkowski Adam , Demkow Marcin 
Published: February 2018

Background—
Device-related thrombus (DRT) after left atrial appendage occlusion is a worrisome finding with little knowledge about when to expect it and how to prevent it. This study sought to investigate correlates of DRT after left atrial appendage occlusion, its time of diagnosis, and particularly, association with postimplantation dual antiplatelet therapy duration.

Methods and Results—

Consecutive patients (n=102) after left atrial appendage occlusion with AMPLATZER Cardiac Plug/Amulet (n=59) or WATCHMAN (n=43) were included in a prospective registry (October 2011–May 2016). Follow-up was done at 1.5, 3 to 6, and 12 months postimplantation. DRT was classified as early (at 1.5 month), late (at 3–6 month), or very late (at 12-month follow-up). Postimplantation dual antiplatelet therapy was recommended for 30 to 180 days and decided independently by attending physicians. Final analysis included 99 patients, 42 (42.4%) females, with median CHA
2
DS
2
-VASc of 4.0 (interquartile range [IQR], 3.0–5.0) and median HAS-BLED score of 2.0 (IQR, 1.0–3.0). DRTs were observed in 7 (7.1%) patients: 2 (28.6%) early, 2 (28.6%) late, and 3 (42.9%) very late. When compared with patients without DRT, those with DRT presented more often with a history of prior thromboembolism (5 [71.4%] versus 28 [30.4%];
P
=0.04), had lower left ventricular ejection fraction (50.0 [IQR, 35.0–55.0] versus 60.0 [IQR, 55.0–66.0];
P
<0.01), and had greater proportion of patients with deep device implantation (6 [85.7%] versus 36 [39.1%];
P
=0.04) and with larger devices implanted (30.0 mm [IQR, 27.0–33.0] versus 25.0 mm [IQR, 24.0–28.0];
P
<0.01). Postimplantation dual antiplatelet therapy duration was not different between the 2 groups (12.4 weeks [IQR, 6.0–49.7] with DRT versus 13.0 weeks [IQR, 7.3–26.0] without DRT;
P
=0.77).

Conclusions—
In this real-world series, DRT was observed early, late, and very late after left atrial appendage occlusion. It was related to patient and procedural characteristics but not to postimplantation dual antiplatelet therapy duration.
The European Union as an Actor in the Law of the Sea, with Particular Reference to the Arctic
Authors: Churchill Robin 
Published: February 2018

Abstract
The first part of this article explores the extent to which the European Union (EU) is an actor in the law of the sea. After explaining when, why and how the EU became such an actor, it considers the legal and political constraints on the capacity of the EU to act; the interests that have shaped its role as an actor; and the various means by which it acts. The second part of the article applies the conclusions from this analysis to outline the role that the EU has so far played in the ongoing development of the legal regime of the marine Arctic and to predict the role that it will continue to play, especially as regards navigation, fisheries, the exploitation of offshore oil and gas, and the protection of the environment.
Still no Evidence for Sustained Effects of Multisensory Integration of Duration
Authors: de la Rosa Maria D. , Bausenhart Karin M. 
Published: February 2018

Abstract
In studies on temporal order perception, immediate as well as sustained effects of multisensory integration have been demonstrated repeatedly. Regarding duration perception, the corresponding literature reports clear immediate effects of multisensory integration, but evidence on sustained effects of multisensory duration integration is scarce. In fact, a single study [Heron, J. et al. (2013). A neural hierarchy for illusions of time: Duration adaptation precedes multisensory integration, J. Vis. 13, 1–12.] investigated adaptation to multisensory conflicting intervals, and found no sustained effects of the audiovisual conflict on perceived duration of subsequently presented unimodal visual intervals. In two experiments, we provide independent evidence in support of this finding. In Experiment 1, we demonstrate that adaptation to audiovisual conflict does not alter perceived duration of subsequently presented visual test intervals. Thus, replicating the results of Heron et al. (2013), we observed no sustained effect of multisensory duration integration. However, one might argue that the prolonged exposure to consistent multisensory conflict might have prevented or hampered multisensory integration per se. In Experiment 2, we rule out this alternative explanation by showing that multisensory integration of audiovisual conflicting intervals is still effective after exposure to audiovisual conflict. This further strengthens the conclusion that multisensory integration of interval duration affects perception in an immediate, but not in a sustained manner.
Media Democratization in Ecuador
Authors: Anderson Tim 
Published: February 2018

A regulatory process of “democratizing the media” based on recent constitutional guarantees and a 2013 communications law is under way in Ecuador. The initiative comes from a demand for new forms of social accountability and participation in the mass media after the Latin American experience of media companies’direct engagement in coups and the destabilization of progressive governments. Media democratization is seen as necessary for the construction of democratic societies. It is distinct in Latin America from recent Northern approaches, which tend to be technocratic, suggesting democratic transformation through new online media and enhanced consumer options. Ecuador’s process follows similar initiatives in Venezuela, Bolivia, Argentina, and Uruguay but is perhaps more articulate and systematic. It is instructive in that it builds on well-established public policy themes of the containment of monopoly power, redress of civil wrongs, and the promotion of participation and diversity. While media corporations mostly seek to disqualify debate on media regulation, Ecuador’s approach deserves closer examination. Ecuador está llevando a cabo un proceso de “democratización de medios” basado en las recientes garantías constitucionales y la ley de comunicaciones de 2013. La iniciativa responde a una exigencia de nuevas formas de responsabilidad social y participación en los medios de comunicación masivos a raíz de experiencias latinoamericanas en las cuales ciertas compañías de medios han intervenido para desestabilizar o generar golpes de estado contra gobiernos progresistas. La democratización de los medios se considera necesaria para la construcción de sociedades democráticas, y esta aproximación se distingue de aquellas características del hemisferio norte con sus tendencias tecnocráticas, que sugieren que la transformación democrática se ha de llevar a cabo mediante nuevos medios en línea y opciones de consumo más amplias. El proceso ecuatoriano se suma a iniciativas similares en Venezuela, Bolivia, Argentina y Uruguay, pero es quizá más articulado y sistemático. Se basa en temas de política pública establecidos como la contención del poder monopólico, la rectificación de delitos civiles, y la promoción de la participación y la diversidad. Si bien las corporaciones de medios han buscado descalificar los debates en torno a la mencionada regulación, los esfuerzos ecuatorianos merecen ser examinados más de cerca.
Analysis of Graft Length Change Patterns in Medial Patellofemoral Ligament Reconstruction via a Fluoroscopic Guidance Method
Authors: Matsushita Takehiko , Araki Daisuke , Hoshino Yuichi , Oka Shinya , Nishida Kyohei , Tanaka Toshikazu , Miyaji Nobuaki , Kanzaki Noriyuki , Ibaraki Kazuyuki , Matsumoto Tomoyuki , Kurosaka Masahiro , Kuroda Ryosuke 
Published: February 2018

Background: A fluoroscopic guidance method for medial patellofemoral ligament (MPFL) reconstruction has been widely used to determine the anatomic femoral attachment site. Purpose: To examine the graft length change patterns in MPFL reconstruction with a fluoroscopic guidance method. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Forty-four knees of 42 patients who underwent MPFL reconstruction for the treatment of recurrent patellar dislocation were examined prospectively. During surgery, suture anchors were inserted into the proximal one-third and center of the patella. A guide pin for the femoral tunnel was inserted into the position reported by Schöttle et al based on the true lateral view of the knee under fluoroscopic control. Changes in graft length patterns of the proximal and center anchors were examined through 0° to 120° of knee flexion. Favorable changes in length patterns were defined as meeting 2 of 3 criteria: (1) not long during flexion (≤3 mm between 30° and 120° of flexion) and either (2) nearly isometric during flexion between 0° and 90° or (3) slightly long during maximum extension (≤3 mm). Other patterns were considered unfavorable. If the change in length pattern was unfavorable, then the pin for the femoral tunnel was moved to different positions until it was favorable. Knees were separated into the favorable group and the unfavorable group. Differences between the groups regarding radiographic parameters were assessed. Student t test or chi-square test was used for statistical analysis. Results: Of the 44 knees, 31 (70.5%) showed favorable patterns. However, 13 knees (29.5%) showed unfavorable patterns; therefore, the position of the pin was changed. The mean ± SD distance from the original position to the final position was 5.3 ± 1.1 mm distal for 7 patients and 5.2 ± 0.4 mm posterodistal for 6 patients. Technical errors, including a nontrue lateral view and the tip of the wire not being in the determined area, were found for 4 of 13 knees in the unfavorable group. There was no statistical difference in radiographic parameters between the groups. Conclusion: The graft length change pattern could be nonphysiologic at the position determined through the fluoroscopic guidance method; thus, caution may be necessary. The change in length pattern should be checked before graft fixation. If the length change pattern is unfavorable, then it is advisable to move it approximately 5 to 7 mm distally or posterodistally from the first position.
Searching for Evidence of an Anti-Inflammatory Diet in Children: A Systematic Review of Randomized Controlled Trials for Pediatric Obesity Interventions With a Focus on Leptin, Ghrelin, and Adiponectin
Authors: Lewis Kimberly A. , Brown Sharon A. 
Published: February 2018

Problem: To address the complex phenomenon of pediatric obesity, one must understand the physiological mechanisms regulating energy intake and inflammation. The peptide hormones leptin, ghrelin, and adiponectin are involved in both, but their functions are dysregulated in obesity. The purpose of this systematic review is (1) to characterize studies of nutrition interventions for weight management in children who measure these peptides as outcomes, (2) to assess risk of bias in the studies, and (3) to determine the relationships between these peptides and body mass index (BMI). Eligibility Criteria: Peer-reviewed articles written in English, published in 2001–2016, and describing randomized controlled trials of pediatric interventions involving a nutrition component with the outcome measures leptin, ghrelin, and/or adiponectin were included. Articles were excluded if the intervention involved pharmaceuticals, supplements, infant formula, breastfeeding, or surgery. Sample: The 25 international studies represented 2,153 obese children. Results: Ten diets were identified. Successful interventions included both structured exercise and hypocaloric dietary components, with or without counseling, resistance training, or medical components. Direct measures of adiposity were used in 69% of studies. Comparison group designs were disparate. Leptin levels decreased as BMI decreased. Evidence regarding the relationships of ghrelin and adiponectin with BMI was inconclusive. Conclusions: Despite known effects of maturation on hormones, studies did not consistently differentiate findings by maturational stage. Common anti-inflammatory and disease risk modification diets were missing or underrepresented. Studies that include children with comorbidities are needed. BMI and leptin levels have a positive relationship, but evidence on ghrelin and adiponectin was inconclusive.
Applying Criterion-Based Indications for Vascular Ultrasound Studies: Planning Quality Improvement
Authors: Wooster Douglas , Angelson Mary 
Published: February 2018

Introduction Although most ultrasound facilities rely on the referring physicians' request for testing, inappropriate indications for ultrasound studies have been cited as a quality metric and source of poor resource use. In 2015, the Intersocietal Accreditation Commission mandated that ultrasound facilities undertake educational and other strategies to address this as a quality improvement initiative, including education of referring physicians. We proposed to study the indications noted in referrals to develop such quality strategies. Methods Dedicated vascular ultrasound facilities were asked to participate. An electronic search of guidelines, standards, and criteria for testing was done. The indication for testing in consecutive patients was collated with adherence to standards and criteria for testing, type of referring physician, patient demographics, and findings. Care gaps were identified to serve as a “needs assessment” for educational and other strategies to address quality improvement. Results Three facilities agreed to participate (one academic, two community). A total of 4,654 studies were analyzed. The vascular domains included were: carotid (610), aorta (217), renal (52), upper extremity arteries (56), lower extremity arteries (1,465), lower extremity venous for deep venous thrombosis (1,377), and lower extremity venous for chronic venous insufficiency (877). Overall, appropriate criteria were cited for 76–96% of studies; the academic facility had higher adherence. There was no difference between family physician and specialist referrals. Diagnostic positive yields were found in 48–68% in different test categories; aortic screening yield was 8.1%. Specific “teaching points” included “headaches” and “neck pain” for carotid studies, aortic screening outside of “targets,” “numb toes,” and “swelling” for arterial duplex; no clear issues were identified for venous studies. Conclusions This study does identify inappropriate indications for vascular ultrasound with no systematic findings. There are specific teaching points that can be used to direct educational strategies for referring physicians.
Correction to: Testing the effectiveness of a motivational interviewing-based brief intervention for substance use as an adjunct to usual care in community-based AIDS service organizations: study protocol for a multisite randomized controlled trial
Authors: Garner Bryan R. , Gotham Heather J. , Tueller Stephen J. , Ball Elizabeth L. , Kaiser David , Stilen Patricia , Speck Kathryn , Vandersloot Denna , Rieckmann Traci R. , Chaple Michael , Martin Erika G. , Martino Steve 
Published: February 2018

AbstractUpon publication of the original article
Ethnic variations regarding clinical profiles and symptom representation in prisoners with psychotic disorders
Authors: Denzel A. Dorina , Harte Joke M. , van den Bergh Mattis , Scherder Erik J. A. 
Published: February 2018

BackgroundBlack and minority ethnic (BME) groups are known to have higher prevalences of psychotic disorders and are over-represented in western penitentiaries and forensic psychiatric institutions. Research from regular mental healthcare settings suggests that they could show different and more severe psychotic symptoms.AimsTo explore ethnic variations in severity of symptomatology of BME and non-BME detainees with psychotic disorders.MethodIn this study, 824 patients with psychotic disorders from seven different ethnic groups, imprisoned in a penitentiary psychiatric centre in the Netherlands, were compared on symptom severity and symptom representation using the BPRS-E clinical interview. Data were analysed by means of a multilevel analysis.ResultsBME patients with psychotic disorders are over-represented in forensic psychiatry, and symptom profiles of prisoners with psychotic disorders vary by ethnicity. Additionally, severity levels of overall psychopathology differ between ethnic groups: patients with an ethnic majority status show more severe levels of psychopathology compared with BME patients.ConclusionsThere are differences in symptom severity and symptom profiles between BME patients and non-BME patients. Disregarding these differences could have an adverse effect on the outcome of the treatment. Possible explanations and clinical impact are discussed.Declaration of interestNone.
BJPsych Open editorial transition: opportunity, challenge and vision
Authors: Kaufman Kenneth R. 
Published: February 2018

SummaryBJPsych Open enters its fourth year with a transition in leadership and a new Editor-in-Chief (EIC). This editorial summarises the Journal's metrics through its first 36 months, provides insights into the Journal's history and growth, and shares the aspirations of the new EIC for BJPsych Open.Declaration of interestK.R.K. is Editor-in-Chief of BJPsych Open; he took no part in the peer-review of this work.
Parametric Prediction from Parametric Agents
Authors: Luo Yuan , Shah Nihar B. , Huang Jianwei , Walrand Jean 
Published: February 2018

We consider a problem of prediction based on opinions elicited from heterogeneous rational agents with private information. Making an accurate prediction with a minimal cost requires a joint design of the incentive mechanism and the prediction algorithm. To elicit heterogeneous agents’ private information and incentivize agents with different capabilities to act in the principal’s best interest, we design an optimal joint incentive mechanism and prediction algorithm called COPE (COst and Prediction Elicitation), the analysis of which offers several valuable engineering insights. First, when the costs incurred by the agents are linear in the exerted effort, COPE corresponds to a “crowd-contending” mechanism, where the principal only employs the agent with the highest capability. Second, when the costs are quadratic, COPE corresponds to a “crowdsourcing” mechanism that employs multiple agents with different capabilities at the same time. Numerical simulations show that COPE improves the principal’s profit (The improvement is 5%–30% in our simulations), comparing to those mechanisms that assume all agents have equal capabilities. The online appendix is available at https://doi.org/10.1287/opre.2017.1681 .
HABITUAL DISLOCATION OF THE SHOULDER
Authors: Osmond-Clarke H. 
Published: February 2018

1. The history of the genesis of the Putti-Platt operation for habitual dislocation of the shoulder is outlined so far as it is known. 2. The operation is described and briefly commented upon. 3. Since there is both gleno-labrial detachment and defect in the humeral head successful treatment depends upon: i) a block to the exit of the humeral head in front and ii) limitation of external rotation movement.
ARTHRODESIS IN TUBERCULOSIS OF THE HIP JOINT
Authors: Dobson J. 
Published: February 2018

1. Fifty cases of arthrodesis of the hip joint in tuberculous arthritis are analysed; in forty cases the late end-result has been ascertained two or more years after operation. 2. The indications for arthrodesis are discussed. The operation should not be performed when disease is active; it should not be undertaken before the age of twelve to thirteen years; it is not advisable in elderly patients; it may be contra-indicated when there are multiple foci of infection. Subject to these limitations every patient with unsound ankylosis after adequate conservative treatment should be treated by arthrodesis; painful fibrous ankylosis and late onset of deformity are definite indications. 3. Three types of operation have been used: intra-articular arthrodesis; extra-articular ilio-femoral arthrodesis; combined intra- and extra-articular arthrodesis. Extra-articular ilio-femoral arthrodesis is preferred, deformity being first corrected by traction or osteotomy. 4. Post-operation complications were few; the mortality rate was low (2 per cent.). 5. There was bone ankylosis with solid incorporation of the graft in 87Â·5 per cent., failure of union of the graft (to the trochanter) in 10 per cent., and destruction of the graft in 2Â·5 per cent. 6. Late end-results show full working capacity in 87Â·5 per cent. of patients, part working capacity in 2Â·5 per cent. and inability to work in 7Â·5 per cent. The writer wishes to express his thanks to Professor Harry Platt and Professor T. P.. McMurray for criticism and advice in the preparation of this paper, and to Dr F. C. S. Bradbury, Central Consultant Tuberculosis Officer of the Lancashire County Council, for permission to publish these cases.
THE MOVEMENTS OF BONES AND JOINTS
Authors: MacConaill M. A. 
Published: February 2018

1. Two successive movements at a joint, if not in one and the same plane, constitute a diadochal movement. 2. Diadochal movements impose conjunct rotation upon the bone which has been moved. This may be countered by a rotation of opposite sense. 3. All muscles of a given joint are, therefore, rotators in some degree. 4. Upon the basis of these principles diagnostic and therapeutic suggestions are made.