bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment and Characterization of Pemetrexed-resistant NCI-H460/PMT Cells
Authors: Xu Yu-Lian , Jiang Xiao-Ming , Zhang Le-Le , Chen Xiuping , Huang Zhang-Jian , Lu Jin-Jian 
Published: March 2019

Background:Pemetrexed (PMT) is a multitargeted antifolate agent that is used for treating patients with Non-Small Cell Lung Cancer (NSCLC). However, patients have presented clinical responses of drug resistance to PMT.Objective:This study aimed to explore the underlying mechanisms of PMT resistance in NSCLC cells.Methods:PMT-resistant NCI-H460/PMT cells were established by treating with PMT in a concentrationescalation manner. MTT assay and colony formation were performed to detect cell proliferation. Immunofluorescence was used to detect the expression of Ki-67. Transwell assay was performed to measure cell migration ability. qPCR and Western blot were used to detect the mRNA and protein expression levels of indicated genes. Small interfering RNAs (siRNA) were used to knockdown ATP binding cassette subfamily B member 1 (ABCB1) and Thymidylate Synthase (TYMS).Results:This study showed that compared with the parental cells, the NCI-H460/PMT cells displayed weakened proliferation and enhanced cell mobility. In addition, the NCI-H460/PMT cells demonstrated cellular senescence, which might result in PMT resistance. The NCI-H460/PMT cells exhibited cross-resistance to other chemotherapeutics, including fluorouracil, paclitaxel, doxorubicin, etoposide and gemcitabine, possibly because of the upregulated expression of ABCB1. However, the ABCB1 knockdown by siRNA failed to eradicate PMT resistance. Moreover, TYMS, a target of PMT, was obviously upregulated in the resistant cells. The genetic silence of TYMS partially abrogated PMT resistance, suggesting that the overexpression of TYMS was a key resistant mechanism of PMT.Conclusion:The overexpression of TYMS was an important resistance mechanism of PMT for KRAS-mutated NCI-H460 cells. Cross-resistance to other chemotherapeutics should be considered in addressing PMT resistance.
Synthesis, Biological Investigation and Docking Study of Novel Chromen Derivatives as Anti-Cancer Agents
Authors: Dube Pritam N. , Sakle Nikhil S. , Dhawale Sachin A. , More Shweta A. , Mokale Santosh N. 
Published: March 2019

Background:
According to the latest global cancer data, cancer burden rises to 18.1 million new
cases and 9.6 million cancer deaths in 2018. Among that female breast cancer ranks as the fifth leading cause of
death (627000 deaths, 6.6%). The main causative factor involved in breast cancer development and progression
is the Estrogen Receptor (ER) which is the essential target for anti-cancer drug discovery. Since millennia ER-α
has been considered as an oncology mark for the treatment of breast cancer.

Methods:
A series of novel 6-methyl-3-(3-oxo-1-phenyl-3-(4-(2-(piperidin-1-yl)ethoxy)phenyl)propyl)-2Hchromen-
2-one was designed, synthesized and screened for their anti-breast cancer activity against estrogen
receptor-positive MCF-7, ZR-75-1 and negative MDA-MB-435 human breast cancer cell lines. Estrogen level
of all the potent cytotoxic compounds were measured on day 30 of intoxication was compared with the control
and N-methyl-N-nitrosourea (MNU) group. The docking study was performed to predict binding orientation
towards the estrogen receptor-α.

Results:
Among the synthesized compounds C-3, C-5 and C-15 were showing potent cytotoxicity against estrogen
receptor-positive MCF-7. The potent cytotoxic compounds C-3, C-5 and C-15 were further evaluated for in
vivo anti-cancer activity by MNU induced mammary carcinoma in female sprague-dawley rats. The in vivo anticancer
activity result shows that the compound C-5 has protuberant affinity towards estrogen receptor as standard
TAM (Tamoxifen). The docking of the synthesized chromen derivatives showed interaction modes comparable
to that of the co-crystallized ligands.

Conclusion:
The designed class has very promising starting point for the development and further improvement
in anti-breast cancer class of drugs.
Recent Progress on Adsorption Materials for Phosphate Removal
Authors: Ahmed Saeed , Ashiq Muhammad Naeem , Li Dianqing , Tang Pinggui , Leroux Fabrice , Feng Yongjun 
Published: March 2019

Background:
High concentration of phosphate has been threatening human health and the
ecosystem. Adsorption is one of high-efficiency and low-cost techniques to reduce the concentration of
phosphate. This mini review aims to summarize the recent development of adsorption materials for
phosphate removal.

Method:
We conducted a detailed search of “adsorption of phosphate” in the published papers and the
public patents on the adsorbents for phosphate based on Web of Science database in the period from January
1 2012 to December 31 2017. The corresponding literature was carefully evaluated and analyzed.

Results:
One hundred and forty one papers and twenty two recent patents were included in this review.
An increased trend in scientific contributions was observed in the development of adsorption materials
for phosphate removal. Three kinds of promising adsorbents: layered double hydroxides, natural materials,
and metal oxides were paid special attention including removal mechanism, performance as well
as the relationship between adsorption performance and structure. Both the chemical composition and
the morphology play a key role in the removal capacity and rate.

Conclusion:
The findings of this review confirm the importance of phosphate removal, show the development
trend of high-performance and low-cost adsorption materials for phosphate removal, and
provide a helpful guide to design and fabricate high-efficiency adsorbents.
Extracción de ADN de bacterias conservadas en el banco de cepas de la Universidad Francisco de Paula Santander sede Campos Elíseos
Authors: Suárez Contreras Liliana Yanet , Yañez Meneses Luz Francy 
Published: March 2019

Actualmente, la identificación de bacterias se realiza con técnicas clásicas basadas en caracterización fenotípica a nivelmacroscópico y microscópico, sin embargo, este método no es fiable y no permite conocer la verdadera identidad delmicroorganismo en estudio. Por esta razón es necesario realizar una identificación a nivel molecular que permita conocer conseguridad el género y especie. El objetivo de este trabajo fue estandarizar el método de extracción de ADN para bacterias Gramnegativas y Gram positivas según la caracterización química, que permitió obtener ADN de buena calidad para la amplificaciónde una región específica de interés. Se evaluaron dos métodos de extracción, el protocolo de Wilson y el Kit de extracciónWizzard (Promega), los dos métodos se diferenciaron en la cuantificación por NanoDrop y se visualizaron por medio de unaelectroforesis en gel de agarosa al 0,8% utilizando el intercalante Gel red. Según el protocolo de Wilson solo se obtuvo ADN debacterias Gram negativas de buena calidad, y la relación 260/280 en el nanodrop (1,8-2). Mientras que el Kit de extracciónWizzard permitió obtener ADN para bacterias Gram positivas y negativas. Se obtuvieron mejores concentraciones de ADN conel protocolo de Wilson, por otra parte no fue posible obtener ADN de bacterias Gram positivas siendo para este caso el kitWizzard un método sin limitaciones para extraer ADN de cualquier género de bacteria; a pesar de lo antes mencionado, porcostos es más conveniente el protocolo de Wilson, para extraer las bacterias Gram negativas. Palabras Claves: Ácidos nucleicos,Bacillus thurigiensis,E. coli,Microorganismos
Servicio web para la geolocalización de los vehículos de transporte público en la ciudad de Cúcuta
Authors: Castro Correa Jhon Alejandro , Sepúlveda Mora Sergio Basilio , Medina Delgado Byron , Guevara Ibarra Dinael 
Published: March 2019

En la ciudad de Cúcuta el medio de transporte que predomina para la movilización de personas entre un punto y otro es elautobús tradicional, dicho servicio no ofrece a los usuarios la posibilidad de conocer de forma precisa el trayecto y el itinerariode los autobuses que transitan por la ruta. Este trabajo está orientado a diseñar e implementar un servicio web que permitavisualizar en tiempo real las rutas y los vehículos de transporte público que circulan en la ciudad de Cúcuta. La geolocalizaciónde los autobuses se realizó mediante un GPS que proporciona el posicionamiento de los vehículos mediante el protocolo NMEA0183; esta información es almacenada en un servidor para luego ser enviada (usando PHP) y visualizada. La interfaz de usuariose desarrolló a través de un sitio web funcional y de diseño adaptable para computadoras, tabletas y celulares utilizando HTML5,CSS3 y JavaScript, donde dependiendo de la ruta escogida se realiza una petición al servidor para obtener los datoscorrespondientes y mostrarlos en un mapa utilizando la API de Google Maps. Se implementó el servicio web permitiendovisualizar las rutas y la posición del vehículo en tiempo real junto con distintas variables de interés como el estado demovimiento o reposo, velocidad, rumbo y tiempo de llegada a cada una de las paradas preestablecidas en la ruta; asimismodentro del portal web se da la posibilidad de generar registros históricos concernientes a la ubicación y recorrido de cada autobúsque son visualizados mediante tablas y gráficas generadas por el usuario.
Palabras Clave: Geolocalización,GPS,Servicio web,Servidor web,Transporte público
Crecimiento sostenible y factores de competitividad del sector calzado en Cúcuta
Authors: Dávila López Fabián Yesid , Sierra Caceres William Armando , Riaño Solano Miller 
Published: March 2019

Este artículo es producto de un trabajo de investigación donde se relaciona los factores de competitividad, la tasa de cambio y la capacidad de crecimiento sostenible del sector calzado de Cúcuta en el periodo 2009-2013. A nivel metodológico se desarrolló como un estudio descriptivo exploratorio, documental y de campo, se utilizó la técnica de encuestas y el juicio de expertos. La población estuvo conformada por veintidós (22) empresas y se efectuó un censo debido al pequeño tamaño de la población. Se evaluaron los factores internos de competitividad y se utilizó el modelo de Higgins para analizar la capacidad de crecimientosostenible. Los factores de competitividad muestran amplio espacio de mejora en el sector, por su parte la tasa de crecimiento sostenible está por debajo de la tasa de crecimiento de ventas del sector calzado en Cúcuta, siendo así se recurre al apalancamiento con recursos externos y a la optimización de la política de dividendos para mejorar el índice de crecimiento intrínseco.
Palabras Clave: competitividad,crecimiento intrínseco,crecimiento sostenible,sector calzado,tasa de cambio
El programa de las 100 mil viviendas gratis y su impacto en la dinámica social, cultural y ambiental de los beneficiarios de los proyectos del municipio de San José de Cúcuta, periodo 2013-2015
Authors: Coronel Ruiz Luz Karime 
Published: March 2019

El concepto de vivienda digna, consagrado en el artículo 51 de la constitución política colombiana, establece que todos loscolombianos tenemos como derecho fundamental el acceso a una vivienda en condiciones que garanticen su disfrute y confort,marco que genera un pilar de desarrollo estratégico en el plan de gobierno del expresidente Juan Manuel Santos durante suprimer periodo presidencial en los años 2010 – 2014 y que retoma con más fuerza en los años subsecuentes de su segundomandato. Con la adopción del programa nacional de las “Cien Mil Viviendas Gratis para los más Vulnerables”, el gobiernopromueve la adjudicación de viviendas con carácter de gratuidad para aquellas comunidades sisbenizadas de los estratos 1 y 2,victimas del posconflicto y damnificados, que debido a su frágil condición socio-económica, no podían acceder a otros métodosde adquisición de vivienda formal en los diferentes puntos del suelo nacional. En concordancia, la aplicación de esta nuevapolítica pública, trajo consigo nuevas dinámicas territoriales durante su proceso de implementación, dinámicas, que aún siguenmanifestándose en los proyectos de vivienda que fueron ejecutados, como es el caso de los proyectos denominados:Cormoranes, San Fernando del Rodeo, Ciudad Rodeo y Los Estoraques, del municipio de San José de Cúcuta. El presenteestudio de caso de investigación, esta direccionado a conocer de manera más clara el impacto que ha tenido mencionadoprograma nacional, sobre sus beneficiarios directos en estos proyectos de vivienda en el municipio de Cúcuta y las dinámicassociales, culturales y ambientales subyacentes.
Palabras Claves: Dinámica Ambiental,Dinámica Cultural,Dinámica Social,Impacto,Vivienda
Full-mouth Rehabilitation of Hypocalcified-type Amelogenesis Imperfecta With Chairside Computer-aided Design and Computer-aided Manufacturing: A Case Report
Authors: Moussally C , Fron-Chabouis H , Charrière A , Maladry L , Dursun E 
Published: March 2019

SUMMARY

Background:
This case report describes the complete full-mouth treatment of hypocalcified amelogenesis imperfecta (AI) by chairside computer-aided design and computer-aided manufacturing (CAD/CAM).

Case summary:
After several years of interrupted dental care, a 17-year-old female patient presented with pain and also esthetic and functional discomfort. With loss of enamel and dyschromia affecting all teeth, the diagnosis was hypocalcified AI. Affected tissues were eliminated, gingivectomy with laser was performed, an indented jig was used to record the centric relationship during optical impressions, and 28 full ceramic crowns were created by chairside CAD/CAM in four sessions. The patient reported rapid pain relief and an overall improvement of well-being.

Conclusion:
AI sequelae can be treated promptly and conservatively with chairside CAD/CAM, obtaining esthetic and functional results.
Effect of Immediate Dentin Sealing on the Bond Strength of Monolithic Zirconia to Human Dentin
Authors: Rigos AE , Dandoulaki C , Kontonasaki E , Kokoti M , Papadopoulou L , Koidis P 
Published: March 2019

SUMMARY

Objective:
This study evaluated the shear bond strength (SBS) of pretreated monolithic zirconia surfaces bonded to human dentin following immediate dentin sealing (IDS) using two different self-adhesive resin luting agents.

Methods and Materials:
Sixty intact human third molars were collected, stored, sectioned appropriately, and molded according to ISO 29022:2013, resulting in 120 dentin specimens. Ceramic cylindrical specimens were fabricated using CAD/CAM technology and sintered as recommended (final bonding area A=2.56 mm2). Specimens were randomly assigned to eight groups (15≥n≥14) depending on dentin conditioning method (IDS or delayed dentin sealing [DDS]), zirconia surface pretreatment (airborne particle abrasion [APA] with 50 μm Al2O3 particles at 3 bar for 10 seconds or tribochemical silica coating [TBC] with 30 μm CoJet particles at 2.8 bar for 10 seconds), and adhesive luting agent type (Panavia F2.0 [PAN] or PermaCem Dual Smartmix [PER]). Bonded specimens were water-stored (37°C, 24 hours) and subjected to SBS testing (50-kgF load cell, 1 mm/min). Fracture type was evaluated with stereomicroscopy. Data (MPa) were statistically analyzed using three-way analysis of variance (α=0.05).

Results:
All factors significantly affected SBS values (p&lt;0.001). Dentin conditioning method presented the greatest effect. Mean SBS values ranged from 12.603 MPa (PER-APA-DDS) to 40.704 MPa (PER-TBC-IDS). Based on the fracture type, adhesive failures at the luting agent–zirconia interface were the least common.

Conclusion:
Bonding strategies for monolithic zirconia restorations could potentially benefit from IDS, regardless of the adhesive luting agent system used.
PENGEMBANGAN KURIKULUM BAHASA ARAB DI MADRASAH
Authors: . Roviin . 
Published: March 2019

Abstract
This article is motivated by the need for the development of Arabic language curriculum in madrasa. Developing Arabic language curriculum in madrasa refers to the Rule of the Minister of Religious Affairs of the Republic of Indonesia, Number: 165 of 2014 on Guidance of Curriculum in Madrasa 2013, Subject of Islamic Education and Arabic Language in Madrasa. In curriculum development, each approach, model and procedure has advantages and disadvantages. However, in the context of Arabic learning in madrasa, the functional approach is more appropriately used with the model of combining all language skills as well as in a theme called the â€œall in one systemâ€/nadhariyya al-wihda. From this approach and model can be realized through a joint procedure between top-down and bottom-up. The content standards for the Arabic language curriculum are thematically constructed for use in four language skills, namely listening (istima'), speaking (kalam), reading (qira'ah) and writing (kitabah).

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Authors: INAMI MUHAMMAD , AMALI PUTRI 
Published: March 2019

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Validation of Building Energy Modeling Tools for a Residential Building in Brasov Area-Romania
Authors: Cîrstolovean Lucian , Mizgan Paraschiva 
Published: March 2019

Abstract
A building energy model is a simulation tool which calculates the thermal loads and energy use in buildings. Building energy models provide valuable insight into energy use in buildings based on architecture, materials and thermal loads. In addition, building energy models also must account for the effects of the building’s occupants in terms of energy use. In this paper we discuss building energy models and their accuracy in predicting energy use. In particular, we focus on two types of validation methods which have been used to investigate the accuracy of building energy models and on how they account for their effects on occupants. The analyzed building is P + M located in the climatic zone 4, Sânpetru / Braşov. We have carried out a detailed and exemplary energy needs analysis using two methods of analysis.
Analysis on Variability of Buzau River Monthly Discharges
Authors: Mocanu-Vargancsik Cristina Amalia , Barbulescu Alina 
Published: March 2019

Abstract
The purpose of this article is analysing the variability of Buzau river monthly mean discharges, maximum and minimum over time and the impact of Siriu Dam on these discharges. Keeping a stable, moderate variability on the water flow has a significant importance, as this assures normality of life and functionality of the dams. On another hand, the dams are in-built with a range of parameters, decided according to this variability of the discharges. The used data has been collected from Nehoiu and Basca Roziliei hydrometric stations and spans on 55 years, from 1st January 1955 to 31st December 2010. Mid-period, on 30th September 1984, Siriu Dam started operating and the results reveal that its impact on the variability has been moderate on a large time scale. Important changes appear on smaller time scale, as months. The results are supported by graphs drawn in Excel and methods embedded by software.