bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFICACY OF HYPOFRACTIONATED ADJUVANT RADIATION THERAPY IN PATIENTS WITH OPERABLE BREAST CANCER
Authors: Afonin G. V. , Ragulin Y. A. , Gulidov I. А. , Beketov Е. E. , Kaprin A. D. 
Published: November 2018

The purpose of the studywas to evaluate the efficacy and safety of hypofractionated postoperative radiation therapy (2.7 Gy per fraction in 15 fractions to a total dose of 40.5 Gy) in comparison with the standard fractionation regimen.Material and methods.The study included 321 patients diagnosed with stage I–IIIA breast cancer treated in the A. Tsyb Medical Radiological Research Center from 2013 to 2017. The patients were divided into two groups. Group I patients received hypofractionated postoperative radiotherapy at a total dose of 40.5 Gy in 15 fractions with Gy 2.7 Gy/fraction (n=223). Group II patients received conventional radiotherapy at a total dose of 50 Gy in 25 fractions with 2 Gy/fraction (n=98). Both groups were comparable in terms of the stage of the disease and molecular subtype of the tumor. The statistical analysis of the main characteristics of the studied regimens was carried out.Results.The analysis revealed no significant differences in the overall survival (OS) and disease-free survival (DFS) between two groups. The frequency of acute radiation-induced complications (grade 1 and 2) in Groups I and II were 79 % and 84 %, respectively. Late radiation-induced side effects were observed less frequently in patients treated with hypofractionated postoperative radiotherapy than in the control group patients (23 % versus 43 %, p<0.01). Severe post-radiation damage to normal tissues was not found. The extent of surgery did not affect the long-term treatment outcomes.Conclusion.Comparison of hypofractionated radiotherapy with conventional radiotherapy in breast cancer patients demonstrated the superiority of hypofractionated radiotherapy regimen in terms of late toxicity and economic profitability. Further studies of accelerated fractionated postoperative radiotherapy are required to improve the treatment outcomes in breast cancer patients.
THE FIRST EXPERIENCE OF USING LAPAROSCOPIC GAMMA PROBE FOR INTRAOPERATIVE VISUALIZATION OF SENTINEL LYMPH NODES IN GYNECOLOGICAL CANCER
Authors: Ochirov M. O. , Kolomiets L. A. , Chernov V. I. , Sinilkin I. G. , Chernyshova A. L. , Villert A. B. , Molchanov S. V. , Churuksaeva O. N. , Kishkina A. Yu. 
Published: November 2018

Visualization of sentinel lymph nodes (SLN) is now widely accepted for lymph node (LN) detection using a radioactive lymphotropic trace. Preoperative lymphoscintigraphy with intraoperative lymphatic mapping under gamma detecting probe guidance proved to be an easy and reliable method for SLN detection.Material and methods.In this article we present our experience in using laparoscopic gamma-probe for intraoperative visualization of sentinel lymph nodes in gynecological cancer.Results.Intraoperative visualization of sentinel lymph nodes in young cervical cancer patients and in patients with stage I endometrial cancer allowed us to perform radical surgery with personalization of the extent of lymph node dissection, especially for patients with low and intermediate risks of lymphogenic metastasis.
Selective Photodynamic Effects on Breast Cancer Cells Provided by p123 Pluronic®- Based Nanoparticles Modulating Hypericin Delivery
Authors: Damke Gabrielle Marconi Zago Ferreira , Souza Raquel Pantarotto , Montanha Maiara Camotti , Damke Edilson , Gonçalves Renato Sonchini , César Gabriel Batista , Kimura Elza , Caetano Wilker , Hioka Noboru , Consolaro Marcia Edilaine Lopes 
Published: November 2018

Background:Breast cancer is the most relevant type of cancer and the second cause of cancer- related deaths among women in general. Currently, there is no effective treatment for breast cancer although advances in its initial diagnosis and treatment are available. Therefore, the value of novel anti-tumor therapeutic modalities remains an immediate unmet need in clinical practice. Following our previous work regarding the properties of the Pluronics with different photosensitizers (PS) for photodynamic therapy (PDT), in this study we aimed to evaluate the efficacy of supersaturated hypericin (HYP) encapsulated on Pluronic® P123 (HYP/P123) against breast cancer cells (MCF-7) and non-tumorigenic breast cells (MCF-10A).Methods:Cell internalization and subcellular distribution of HYP/P123 was confirmed by fluorescence microscopy. The phototoxicity and citototoxicity of HYP/P123 was assessed by trypan blue exclusion assay in the presence and absence of light. Long-term cytotoxicity was performed by clonogenic assay. Cell migration was determined by the wound-healing assay. Apoptosis and necrosis assays were performed by annexin VFITC/ propidium Iodide (PI) by fluorescence microscopy.Results:Our results showed that HYP/P123 micelles had high stability and high rates of binding to cells, which resulted in the selective internalization in MCF-7, indicating their potential to permeate the membrane of these cells. Moreover, HYP/P123 micelles accumulated in mitochondria and endoplasmic reticulum organelles, resulting in the photodynamic cell death by necrosis. Additionally, HYP/P123 micelles showed effective and selective time- and dose dependent phototoxic effects on MCF-7 cells but little damage to MCF-10A cells. HYP/P123 micelles inhibited the generation of cellular colonies, indicating a possible capability to prevent the recurrence of breast cancer. We also demonstrated that HYP/P123 micelles inhibit the migration of tumor cells, possibly by decreasing their ability to form metastases.Conclusion:Taken together, the results presented here indicate a potentially useful role of HYP/P123 micelles as a platform for HYP delivery to more specifically and effectively treat human breast cancers through photodynamic therapy, suggesting they are worthy for in vivo preclinical evaluations.
Symptoms of Toxicity and Plasma Cytochrome c Levels in Human Immunodeficiency Virus-infected Patients Receiving Anti-retroviral Therapy in Ghana: A Cross-sectional Study
Authors: Mensah Eric A. , Sarfo Bismark , Bonney Evelyn Y. , Parbie Prince K. , Ocloo Augustine 
Published: November 2018

Background:
Side effects and toxicity have posed a threat to the positive contribution
of Antiretroviral Therapy (ART) in the management of human immunodeficiency virus (HIV) infection
and Acquired Immune Deficiency Syndrome (AIDS). Symptoms of mitochondrial toxicity
including myopathy, pancreatitis, hyperlipidaemia and lactic acidosis are found among HIVinfected
patients on ART. To date, there is not a reliable biomarker for monitoring ART-related
mitochondrial toxicity. Plasma level of Cytochrome c (Cyt-c) has been proposed as a potential
biomarker for ART-related toxicity due to its strong association with apoptosis.

Objective:
The present study assessed toxicity and level of plasma Cyt-c among HIV-infected patients
receiving ART in Ghana.

Methods:
A total of eighty (80) HIV patients were recruited into the study. Demographic data
were obtained from personal interview and medical records. Plasma samples were screened for
toxicity from sixty (60) participants due to limited resources, and plasma Cyt-c levels were determined
using ELISA. Data were analyzed using Stata version 13.

Results:
Out of the 60 participants, 11 (18.3%) were found with symptoms of myopathy, 12
(20%) with pancreatitis, 21 (35%) with hyperlipidaemia and 36 (60%) with at least one of the
symptoms. The concentration of plasma Cyt-c was higher (0.122 ng/ml) in patients with toxicity
than in those without toxicity (0.05 ng/ml), though the difference was not statistically significant
(p = 0.148). There was a weak correlation between plasma Cyt-c level and duration of ART
(Spearman rho = 0.02, p = 0.89).

Conclusion:
This study, therefore, demonstrated a high prevalence of ART-related toxicity and
high levels of Cyt-c in HIV-infected patients in support of the argument that plasma Cyt-c levels
are potential biomarkers for determining ART-related toxicity in HIV patients.
Perancangan Alat Ukur Massa Jenis Zat Cair Menggunakan Cepat Rambat Gelombang Ultrasonik
Authors: Prawira Nanda Bagus , Rouf Abdul 
Published: November 2018

Density is a measure of the mass of volume unity. How to measure density in general by measuring the weight and dividing it by the volume of liquid, so in this way the measurement is not. Measurement of the density of the liquid based on the ultrasonic velocity becomes an alternative so that the measurement can be done directly, accurately, practically, and easily.Ultrasonic velocity becomes the variable to determine the density of the liquid. Time synchronization begins when the ultrasonic transmitter emits ultrasonic and is terminated when the receiver receives ultrasonic. The discrete ultrasonic wave transmission method is performed when the ultrasonic receiver receives transmittance from the ultrasonic transmitter then the 40KHz signal pulse is stopped and ultrasonic transmission is repeated up to 10 times the measurement data.From this study obtained some conclusions. Ultrasonic velocity is influenced by the viscosity of the liquid, ultrasonic velocity through 1394m / s aquades, ultrasonic velocity through cooking oil 1387m / s, ultrasonic velocity through liquid soap 1175m / s, ultrasonic velocity through liquid soap solution 40% 1317m / s , Ultrasonic velocity through liquid soap solution 70% 1257m / s, velocity measurement deviation of 0.43% and 0.01% density calculation type.
Sikap dan Tindakan Masyarakat Terhadap Orang Gila dan Kampung Gila Desa Paringan Kecamatan Jenangan Kabupaten Ponorogo
Authors: Widayat Muh. Aziz 
Published: November 2018

<p>Penelitian ini bertujuan menganalisis dan mendeskripsikan sikap dan tindakan masyarakat terhadap orang gila dan kampung gila Desa Paringan Kecamatan Jenangan Kabupaten Ponorogoa. Penelitian dilaksanakan selama 6 bulan dengan menggunakan pendekatan kualitatif dan metode <em>field research </em>(penelitian lapangan). Informan ditentukan secara <em>purposive</em><em> sampling</em><em>. </em>Pengumpulan datanya dengan teknik observasi, wawancara, dokumentasi. Untuk mendapatkan keabsahan data menggunakan triangulasi sumber. Sedangkan teknik analisis datanya dengan model analisis interaktif Miles dan Huberman. Dari penelitian yang dilakukan diperoleh hasil bahwa sikap masyarakat Desa Paringan walaupun berat namun menerima warga yang mengalami gangguan jiwa (gila). Mereka berusaha melakukan berbagai tindakan untuk membantunya agar warga yang mengalami gangguan jiwa diperlakukan secara manusiawi. Selain itu, untuk mengelimir stigma negatif desanya, masyarakat beserta aparatur pemerintahan desa melaksanakan kegiatan diantaranya; (1) memberdayakan sumber daya alam sebagai destinasi wisata, (2) memberdayaakan ekonomi masyarakat dengan pengolahan diversifikasi makanan ringan.</p>
PELATIHAN AKUNTANSI DAN PENYUSUNAN LAPORAN KEUANGAN BAGI MANAJER DAN STAF KEUANGAN KOPERASI USAHA PENANAMAN DAN PENGOLAHAN KOPI DI KABUPETEN ACEH TENGAH DAN BENER MERIAH
Authors: BZ Fazli Syam , Iskandarsyah Iskandarsyah , Evayani Evayani , Afrianandra Cut 
Published: November 2018

<p><strong><em>Abstract.</em></strong><em> The accounting and financial reporting training aims to provide knowledge (methods / techniques) and accounting practices that start from the accounting cycle in preparing financial statements for cooperative managers and finance staff towards transparent, accountable, accountable, self-sustaining and transparent cooperative governance justice. The cooperative must have a reliable and valid financial management system so that cooperative management that is familial and mutual cooperation requires the active participation and participation of all stakeholders.The training was conducted at the Coffe and Coffeemaking Cooperative in Central Aceh and Bener Meriah Regency involving 45 participants from 13 cooperatives consisting of Managers and Finance Staff. The training was conducted for 3 (three) dated March 17 - 19, 2017. In the initial phase, training needs analysis has been done to obtain preliminary information about understanding and accounting practices in the targeted cooperatives.The final outcomes of training for cooperatives are the preparation of the Preliminary Balance Sheet and the Financial Statements of Cooperatives for the period of December 31, 2016 and the continuing recording of transactions for the period of 2017 until the preparation of the Financial Statements of December 31, 2017.</em></p><p><strong><em>Keywords: Accounting, Financial Statement, Cooperative, Governance</em></strong></p><p><strong> </strong></p><p><strong> </strong></p><p><strong>Abstrak</strong>.Pelatihan akuntansi dan penyusunan laporan keuangan ini bertujuan untuk memberikan pengetahuan (metode/teknik) dan praktik akuntansi yang dimulai dari siklus akuntansi dalam menyusun laporan keuangan bagi para manajer dan staf keuangan koperasi guna menuju tata kelola koperasi yang transparan, akuntabel, bertanggungjawab, mandiri, dan berkeadilan. Koperasi harus memiliki sistem manajemen keuangan yang handal dan valid sehingga tata kelola koperasi yang bersifat kekeluargaan dan gotong royong menuntut peran dan partisipasi aktif dari seluruh anggota <em>(stakeholder</em>). Pelatihan ini dilakukan pada Koperasi Usaha Penamanan dan Pengolahan Kopi di Kabupaten Aceh Tengah dan Bener Meriah yang melibatkan 45 orang peserta dari 13 Koperasi yang terdiri dari Manajer dan Staf Keuangan. Pelatihan dilakukan selama 3 (tiga) tanggal 17 – 19 Maret 2017. Pada tahap awal telah dilakukan analisis kebutuhan pelatihan guna mendapatkan informasi awal tentang pemahaman dan praktik akuntansi pada koperasi yang disasar.Dampak akhir (outcome) dari pelatihan bagi koperasi adalah tersusunnya Neraca Awal dan Laporan Keuangan Koperasi untuk periode 31 Desember 2016 dan berlanjutnya pencatatan transaksi periode tahun 2017 sampai tersusunan Laporan Keuangan 31 Desember 2017.</p><p><strong>Kata Kunci: Akuntansi, Laporan Keuangan, Koperasi, Tata Kelola</strong></p>
PELATIHAN KEWIRAUSAHAAN DAN KOPERASI BERBASIS SYARIAH BAGIPELAKU UMKM DI CEMPAKA PUTIH JAKARTA PUSAT
Authors: Muslikh Muslikh , Deviastri Lily , Hidayati Rini 
Published: November 2018

<p><strong><em>Abstract.</em></strong><em>The purpose ofthisprogramis to raise awarenessandentrepreneurialskillsfor</em><em> SMEs enterprise.The method usedis byapproachingthe SMEs enterpriseto identifythe problemsfaced bythem. The training methods were given by lectures anddiscussionsaboutentrepreneurship. The resultis the increasing of awarenessand understanding ofentrepreneurshipincluded:finance, banking, accounting, marketing, productionand cooperatives. Therefore,entrepreneurship training for SMEs enterprise should be donecontinuously, thus increasingsales turnover.</em></p><p><strong><em>Keyword</em></strong><strong><em>: Training, Entrepreneurship, Cooperation, Based on Syariah, SMEs Enterprise </em></strong></p><p><strong> </strong></p><p><strong>Abstrak. </strong>Tujuan program ini adalah untuk meningkatkan kesadaran dan kemampuan kewirausahaan dan perkoperasian bagi pelaku usaha kecil (UMKM). Metode yang dipergunakan adalah mengadakan pendekatan dengan mitra pelaku usaha kecil untuk mengidentifikasi permasalahan-permasalahn yang dihadapi UMKM. Metode pelatihan dengan ceramah dan diskusi tentang kewirausahan dan perkoperassian berbasis dsyariah. Hasil yang dicapai adalah meningkatnya kesadaran dan pemahaman tentang kewirausahan dan perkoperasian berbasis syariah yang meliputi aspek: keuangan syariah, perbankan syariah, akuntansi syariah, pemasaran online. Pelatihan kewirausahaan dan koperasi berbasis syariah bagi pelaku usaha kecil perlu dilakukan secara berkesinambungan untuk meningkatkan kinerja UMKM.</p><p><strong>Keyword: Pelatihan, Kewirausahaan, Koperasi , Berbasis Syariah, UMKM</strong></p>
PENGUATAN KEMAMPUAN BENDAHARA DAN GURU SD MELALUI PEMBELAJARAN AKUNTANSI DASAR DI SDN MEKARWANGI, DS. MEKARWANGI, KEC. CISAUK, TANGERANG-BANTEN
Authors: Effendi Bahtiar 
Published: November 2018

<p>Abstract. This activity aims to provide an adequate learning about the basic accounting of nonprofit entities to strengthen the ability of treasurers and teachers in recording and reporting of school financial books. The target of this activity is the teachers especially the school treasurer of SDN Mekarwangi.<br />Problems resolved through two stages of learning and mentoring activities. The results of this activity show a positive impact with the improvement of teachers' skills related to school bookkeeping with the provision of the Principal's decision to appoint one teacher of the lesson participants to assistant treasurer. In addition, the results of other activities of the basic accounting concepts have been implemented in the private business of one of the teachers of the learning participants through the business of its sweet potato chips. </p><p> </p><p>Abstrak. Kegiatan ini bertujuan memberikan pembelajaran memadai mengenai akuntansi dasar entitas nirlaba guna penguatan kemampuan bendahara dan guru dalam pencatatan dan pelaporan pembukuan keuangan sekolah. Sasaran kegiatan ini adalah guru-guru terutama bendahara sekolah SDN Mekarwangi. Permasalahan diselesaikan melalui dua tahapan yakni kegiatan pembelajaran dan pendampingan. Hasil kegiatan ini menunjukkan dampak positif dengan peningkatan kemampuan guru terkait pembukuan sekolah dengan dibuktikannya keputusan Kepala Sekolah mengangkat satu guru peserta pembelajaranmenjadi asisten bendahara. Selain itu, hasil kegiatan lainnya konsep akuntansi dasar telah diimplementasi dalam usaha pribadi milik salah satu guru peserta pembelajaran melalui usaha keripik ubinya.</p><p> </p>
Stability of alpha-helical and beta-structural blocks in proteins of four structural classes
Authors: Poboinev V. V. , Khrustalev V. V. , Khrustaleva T. A. , Stozharov A. N. 
Published: November 2018

In this article we showed the characteristic structural features of the groups of interacting alpha-helices and beta-strands (blocks) in four sets of nonhomologous proteins from different structural classes. Stability of each element of secondary structure has been checked with help of the PentaFOLD algorithm that finds intrinsic alpha-helical and beta-structural sequences of amino acid residues. We proved that the most frequent blocks of “alpha + beta” and “alpha/beta” proteins are 2 interacting alpha helices, and they demonstrate the highest level of stability. In alpha-helical proteins the most frequent blocks contain 4 alpha-helices. In beta-structural proteins alpha-helices most frequently do not interact with other helices and demonstrate the lowest level of stability. The most stable type of beta-structure is a block made from three interacting beta-strands, while the less stable one is a beta-hairpin. There is a characteristic distribution of stable alpha-helices in “alpha + beta” proteins: they are usually situated in the beginning of a block while stable beta-strands are usually situated in the end of the block. This type of distribution of stable alpha-helices and beta-strands helps the protein to form its stable three-dimensional structure in case it begins from beta-structural domain which is the most frequent case for the structural class of proteins.
Plasmon-active silver nanostructures in the pores of ion-track template of SiO2 on silicon
Authors: Yakimchuk D. V. , Kaniukov E. Yu. , Bundyukova V. D. , Demyanov S. E. 
Published: November 2018

Today, the possibility of amplifying the signal of Raman scattering is intensively studied in order to realize a simple and reliable tool for monitoring of ultra-small concentrations of chemical and biological substances. Plasmon-active nanostructures can serve as the basic element of substrates for signal amplifying, and the degree of amplification is determined by nanostructures size and shape. The formation of nanostructures with a predetermined morphology requires the development of new approaches. In this concern, the paper considers a complex approach of plasmon-active silver nanostructures with a wide range of shapes and sizes formation in the pores of ion-track Sio2templates on silicon. The peculiarities of SiO2templates creation are considered and the etching rates, uniquely determining the parameters of the pores as a function of the etching time, are established. The features of the silver nanostructures formation in the pores of the SiO2template are described for various pore sizes and synthesis regimes (time and solution temperature). The possibility of formation of nanostructures with different shapes as well as evolution of their morphology with variation of synthesis parameters is shown. on the example of dendrites, having a high potential for practical application for amplification of the Raman scattering signal, the possibility of recording Raman spectra was demonstrated using the model analyzer Nile Blue at the concentration of 10-6M/l. The results indicate that plasmon-active silver nanostructures in the pores of ion-track Si02template on silicon can be used as basic element of biosensors to studying ultra-low doses of chemical and biological substances.Communicated by Corresponding Member Valery M. Fedosyuk
Formalization of the process and development of an algorithm for solid-phase mixing of components of a heterogeneous composite material
Authors: Ilyushchanka A. Ph. , Buloichyk V. M. , Kryvanos A. K. , Piatsiushyk Ya. Ya. 
Published: November 2018

The article considers one of the approaches to modeling the process of mixing of polydisperse powders, which includes three main fractions of different sizes, the shape of which is close to spherical. The work is aimed at reducing material costs at the stage of development of mixing processes by reducing the number of experiments. Aiming to obtain the most uniform mixing with the minimum time of the technological process, the model is based on the target function for a certain number of iterations of mixing of the composition to obtain the required (maximum possible) density of the package of mixed solid particles.To develop a model of the mixing process, one of the heuristic algorithms – the “metal annealing method” – was used. As a representative element of the model, an elementary cell in the form of several hexagonal densely. Packed particles around one introduced into the composition of the composite material (in a small amount, from 5 to 15 %) as a modifier was adopted. The mo del is formalized with the condition of averaging the particle sizes within each fraction, as well as the morphology of their surface. The number of particle repackaging iterations is calculated by the probability of obtaining the minimum amount of voids in the representative element and the uniformity of distribution of the modifying element.Comparison of the values obtained during the simulation with the measured values of the mixing results on a specific mixer will form a scale of compliance of the simulation results with the operating modes of the process equipment. This will make it possible to predict the appropriate mixing modes at the stage of development of the technological process with the possible system of fluctuations in the characteristics of the supplied raw materials and, thereby, to create a methodological basis for the formation of quality management of manufacturing heterogeneous composite material. The model can be adapted for polydisperse powders with the content of the main fractions of more than three.