bluuebunny/crossref_metadata_2025_split huggingface dataset:
ZnxMnO2/PPy Nanowires Composite as Cathode Material for Aqueous Zinc‐Ion Hybrid Supercapacitors
Authors: Xue Yujia , Huo Jinghao , Wang Xin , Zhao Yuzhen 
Published: November 2024

ABSTRACTOver the past decade, the extensive consumption of finite energy resources has caused severe environmental pollution. Meanwhile, the promotion of renewable energy sources is limited by their intermittent and regional nature. Thus, developing effective energy storage and conversion technologies and devices holds considerable importance. Zinc‐ion hybrid supercapacitors (ZISCs) merge the beneficial aspects of both supercapacitors and batteries, rendering them an exceptionally promising energy storage method. As an important cathode material for ZISCs, the tunnel structure MnO2 has poor conductivity and structural stability. Herein, the ZnxMnO2/PPy (ZMOP) electrode materials are prepared by hydrothermal method. Doping with Zn2+ is used to enhance its structural stability, while adding polypyrrole to improve its conductivity. Therefore, the fabricated ZMOP cathode presents superb specific capacity (0.1 A g−1, 156.4 mAh g−1) and remarkable cycle performance (82.6%, 5000 cycles, 0.2 A g−1). Furthermore, the assembled aqueous ZISCs with ZMOP cathode and PPy‐derived porous carbon nanotube anode obtain a superb capacity of 109 F g−1 at 0.1 A g−1. Meanwhile, at a power density of 867 W kg−1, the corresponding energy density can achieve 20 Wh kg−1. And over 5000 cycles at 0.2 A g−1, the cycle performance of ZISCs maintains at 86.4%, which exhibits excellent cycle stability. This suggests that ZMOP nanowires are potential cathode materials for superior‐performance aqueous ZISCs.
Antibacterial Activity, GC MS Analysis and In Silico Validation of Bioactive Compound from Endophytic Fungus Lasiodiplodia pseudotheobromae EF‐9
Authors: Kavitha Kuppuswamy , Yuvaraj Udhayakumar , Rajalakshmi Arumugam , Suresh Gopal , Harini Manoharan , Prabakaran Vadivel , Bharathi Selvaraj , Puvanakrishnan Rengarajulu , Ramesh Balasubramanian 
Published: November 2024

AbstractSecondary metabolites synthesized by endophytic fungi have garnered significant interest for their broad applications in treating various ailments. In this study involving 20 plant samples, 11 endophytic fungi were isolated and cultured, and Lasiodiplodia pseudotheobromae EF‐9, derived from Hibiscus rosa‐sinensis, demonstrated greater antibacterial efficacy than the other isolated endophytes. Phylogenetic analyses using 18S rRNA gene confirmed the EF‐9 identity as L. pseudotheobromae. Following mass production, the active compound was partially purified using column chromatography. The fraction collected at the 60th min exhibited good antibacterial activity against Bacillus coagulans (MTCC 6735) and Shigella flexneri (ATCC 12022), with an inhibition zone of approximately 20 mm in diameter. UV spectral studies revealed a wide absorption band at 430 nm. High Performance Liquid Chromatography (HPLC) of the active fraction showed a distinct peak with a retention time of 4.216 min at 430 nm. Gas Chromatography‐Mass Spectrometry (GC‐MS) identified the active compound in the L. pseudotheobromae EF‐9 culture broth extract as Bis(2‐ethylhexyl) phthalate, which displayed a peak at 16.856 min and covered 66.69 % of the area in the spectral analysis.
Chemical Information Network and Molecular Docking Inspire the Novel Indole Discovery Against Glioma from Tabernaemontana corymbosa
Authors: Peng Yun‐Lin , Song Da , Xue Yan , Han Wei , Liu Xia , Feng Ting‐Ting , Zhou Ying , Wei Xin 
Published: November 2024

AbstractThe alkaloid ingredients were considered to be responsible for the diverse pharmacological activities of the medicinal plant Tabernaemontana corymbosa (Roxb. ex Wall.). In the current finding, the systematic phytochemical investigation on T. corymbosa have been achieved. One new indole alkaloid tabercorympyline A (1) along with seven known indoles (2–8) were isolated from T. corymobsa. Their structures were elucidated by means of spectroscopic techniques and quantum chemical calculations. Tabercorympyline A (1) possessed the indole skeleton with rare N‐containing nine membered ring. Chemical information network was used to comprehensively discover the clues for the glioma therapeutic leads from T. corymbosa alkaloids (TA). Inspired by chemical information network analysis, all the isolated compounds have been further validated their anti glioma activities in glioma cell line U251. Interestingly, the compounds 2, 3, 5, and 6 exhibited significant inhibitory effects on glioma cells in vitro. Molecular docking was ultimately used to indicate possible binding performance and mechanism between active compounds (2–3) and the core targets. This study sequentially assembled chemical information and network analysis, phytochemistry, molecular docking, and in vitro activity validation to comprehensively explore the effective compounds, related targets, and potential mechanisms of TA therapy for glioma.
Visual and Quantitative Analysis of Dietary Fiber‐Microbiota Interactions via Metabolic Labeling In Vivo
Authors: Xu Ningning , Lin Huibin , Lin Liyuan , Tang Mi , Zhang Zhidong , Yang Chaoyong , Wang Wei 
Published: November 2024

AbstractDietary fiber (DF)‐based interventions are crucial in establishing a health‐promoting gut microbiota. However, directly investigating DFs’ in vivo interactions with intestinal bacteria remains challenging due to the lack of suitable tools. Here, we develop an in vivo metabolic labeling‐based strategy, which enables not only imaging and identifying the bacteria that bind with specific DF in the intestines, but also quantifying DF's impact on their metabolic status. Four DFs, including galactan, rhamnogalacturonan and two inulins, are fluorescently derivatized and used for in vivo labeling to visually record DFs’ interactions with gut bacteria. The subsequent cell‐sorting, 16S rDNA sequencing, and fluorescence in situ hybridization identify the taxa that bind each DF. We then select a DF‐binding species newly identified herein and verify its DF‐catabolizing capability in vitro. Furthermore, we find that the indigenous metabolic status of Gram‐positive bacteria, whether inulin‐binders or not, is significantly enhanced by the inulin supplement. This trend is not observed in Gram‐negative microbiota, even for the inulin‐binders, demonstrating the ability of our methods in differentiating the primary, secondary DF‐degraders from cross‐feeders, a question that is difficult to answer by using other methods. Our strategy provides a novel chemical biology tool for deciphering the complex DF‐bacteria interactions in the gut.
Effect of Different Tube Structures on Heat Transfer of Supercritical CO2 in Serpentine Micro‐Tubes
Authors: Lin Chaoqun , Yi Zhengming , Meng Qiu , Xu Yong 
Published: November 2024

AbstractIn order to understand the effect of different tube structures on the heat transfer characteristics of supercritical CO2 in heating serpentine micro‐tubes, five structures are investigated. At the same inlet Reynolds number, because the periodic disturbance frequency of boundary layer and centrifugal force decrease with the increase of curvature radius and the boundary layer thickens with the increase of tube diameter, the comprehensive heat transfer performance of serpentine micro‐tubes decreases with the increase of curvature radius and tube diameter. Gravitational buoyancy is independent of curvature radius but increases with the increase of tube diameter. Centrifugal force and centrifugal buoyancy decrease with the increase of curvature radius and tube diameter.
Bioreactor Engineering for Circular Economy: Bioactive Compound Production in Solid‐State Fermentation—Review
Authors: Gómez‐Ramos Gerardo A. , Prado‐Barragán Lilia A. , Rivera Brianda A. , Huerta‐Ochoa Sergio , Rivera Víctor M. , Couder‐García Moises , García‐Hernández Rocío de los Ángeles , Castillo‐Araiza Carlos O. 
Published: November 2024

AbstractSolid‐state fermentation (SSF) has gained considerable attention due to its potential in the production of bioactive compounds from agroindustrial residues, aligning with circular economy targets. This review examines the core bases involved in SSF with a focus on bioreactor engineering. The review underlines the microorganisms metabolic activities under different operational conditions and focuses on engineering challenges encountered in designing packed‐bed bioreactors, including an analysis of the interaction between microbial growth kinetics and transport phenomena. Finally, given its essential role in the scaling‐up process, this review discusses mathematical modeling developed for SSF in packed‐bed bioreactors, establishing a foundation for the future development of more efficient, scalable, and sustainable SSF‐based applications.
Applying Metallo‐Organic Ligand Design Principles to the Stereoselective Synthesis of a Peptide‐Based Pd2L4X4 Cage
Authors: Brightwell Dominic F. , Samanta Kushal , Muldoon Jimmy , Fleming Patricia C. , Ortin Yannick , Mardiana Lina , Waddell Paul G. , Hall Michael J. , Clark Ewan R. , Fantuzzi Felipe , Palma Aniello 
Published: November 2024

AbstractThe rational and controlled synthesis of metallo‐organic cages using polyaromatic ligands is well established in the literature. There is a strong interest to advance this field towards the use of chiral ligands capable of yielding cages in a stereoselective manner. Herein, we demonstrate that the classical approach for designing metallo‐organic cages can be translated to polyproline peptides, a biocompatible class of chiral ligands. We have successfully designed a series of polyprolines, which mimic the topology of ditopic polyaromatic ligands, to achieve the stereoselective synthesis of a novel Pd lantern cage. This cage exhibits excellent stability in water and demonstrates the stabilization of a highly reactive species in solution. This work will pave the way towards the stereospecific synthesis of more complex, functionalized peptide‐based metallo‐cages.
Bispecific Thio‐Linked Disaccharides as Inhibitors of Pseudomonas Aeruginosa Lectins LecA (PA‐IL) and LecB (PA‐IIL): Dual‐Targeting Strategy
Authors: Faltinek Lukáš , Melicher Filip , Kelemen Viktor , Mező Erika , Borbás Anikó , Wimmerová Michaela 
Published: November 2024

AbstractPseudomonas aeruginosa is a prevalent opportunistic human pathogen, particularly associated with cystic fibrosis. Among its virulence factors are the LecA and LecB lectins. Both lectins play an important role in the adhesion to the host cells and display cytotoxic activity. In this study, we successfully synthesized hardly hydrolysable carbohydrate ligands targeting these pathogenic lectins, including two bispecific glycans. The interactions between LecA/LecB lectins and synthetic glycans were evaluated using hemagglutination (yeast agglutination) inhibition assays, comparing their efficacy with corresponding monosaccharides. Additionally, the binding affinities of bispecific glycans were assessed using isothermal titration calorimetry (ITC). Structural insight into the lectin‐ligand interaction was obtained by determining the crystal structures of LecA/LecB lectins in complex with one of the bispecific ligands using X ray crystallography. This comprehensive investigation into the inhibitory potential of synthetic glycosides against P. aeruginosa lectins sheds light on their potential application in antimicrobial therapy.
One‐step Macrocycle‐to‐Macrocycle Conversion Towards Two New Macrocyclic Arenes with Different Structures and Properties
Authors: Han Xiao‐Ni , Long Yu‐Jie , Guo Wei‐Chen , Han Ying , Chen Chuan‐Feng 
Published: November 2024

AbstractTwo new macrocyclic arenes H1 and H2 were conveniently synthesized by the one‐step reaction of carboxylic acid substituted octopus[3]arene. It was found that H1 was composed of three ethenoanthracene subunits with a rigid hexagonal structure and H2 contained two ethenoanthracene subunits and one anthracene subunit with a rigid house‐shaped structure. Among them, H2 exhibited strong blue fluorescence due to the existence of an anthracene subunit. Moreover, both H1 and H2 showed large and electron‐rich cavities, which enable them to effectively complex different nitrogen‐containing heterocyclic salt guests in solution and the solid state. It was further found that H2 exhibited stronger complexation towards the tested guests than H1 probably due to the stronger charge‐transfer interactions between H2 and the guests.
Multiwavelength Optical Rotation Detection: An Effective Approach for the Recognition of Analytical and Semi‐Preparative HPLC Enantioseparation of the Chiral Pheromone Olean and Its Stereochemical Characterization
Authors: Mammone Francesca Romana , Sadutto Daniele , Cirilli Roberto 
Published: November 2024

ABSTRACTOlean is the chiral spiroacetal sex pheromone of the female olive fruit fly Bactrocera oleae. Laboratory tests have demonstrated that the (R)‐(−)‐olean enantiomer is active on males, whereas females respond to (S)‐(+)‐olean. Here we present the first HPLC enantioseparation of olean using polysaccharide derivatives as chiral stationary phases and a polarimetric detector equipped with a micro‐flow cell capable of detecting optical rotation at six different wavelengths. Unlike blind UV detection, the polarimetric detector allows the chiral spiroacetal, which lacks a chromophore, to be detected as bisegnate peaks, indicating the opposite sign of the optical rotation. The HPLC enantioseparation was optimized on the coated type amylose‐based Chiralpak AS‐H CSP using a mobile phase consisting of n‐hexane‐2‐propanol 99.99:0.01 (v/v). These conditions were scaled up to a semi‐preparative level and allowed resolution of 2.5 mg of racemic sample in 5 min. Multiwavelength optical rotation detection during HPLC enantioseparation of racemic samples provides a direct readout of the stereochemistry of olean and allows tracking of virtual optical rotation dispersion curves without the need for preliminary collection of enantiomeric samples by semi‐preparative HPLC.
Spatially Resolved Measurements in a Stagnation‐Flow Reactor: Kinetics of Catalytic NH3 Decomposition
Authors: Davari Sadaf , Cárdenas Camilo , Hettel Matthias , Lott Patrick , Tischer Steffen , Angeli Sofia , Deutschmann Olaf 
Published: November 2024

AbstractA stagnation‐flow reactor was employed to investigate the decomposition of ammonia over a Ni/Al2O3 catalyst across a range of system pressures and ammonia mole fractions. The results indicate that the system pressure has a negligible impact on the light‐off behavior and the concentration profiles of NH₃. A comparison of 1D modelling with 3D computational fluid dynamics (CFD) computations justifies the use of the simpler flow model. Good agreement between experiments and the 1D simulation is achieved for two different kinetic models from literature in the mainly diffusion‐controlled regime. For lower temperatures, at which the process is kinetically controlled, the two mechanisms exhibit significant differences. The stagnation‐flow reactor concept is shown to be a promising tool for understanding, developing, and validating the reaction kinetics of heterogeneous catalytic processes.
Catalytic Enantioselective Functionalization of Maleimides: An Update
Authors: Amatore Muriel , Bonne Damien , Constantieux Thierry , Rodriguez Jean 
Published: November 2024

Comprehensive SummaryMaleimide derivatives are well‐established reactive intermediates also found in natural products, synthetic pharmaceuticals and functional polymers. Their specific reactivity found widespread applications in the field of bioconjugation and allowed for the development of highly selective functionalizations based on simple additions and cycloadditions with the possible control of central and C–N axial chirality. These multisite‐reactive scaffolds have aroused a long‐standing interest throughout the scientific community more particularly as powerful electrophilic partners and more recently as nucleophilic partners in some specific transformations. The persistent interest in these easily accessible synthetic platforms over the last decade has enabled the development of new enantioselective transformations and the major advancements in this field are presented in this review.
Key Scientists
A Comparison Between Culprit Versus Complete Revascularization in Diabetic Patients With Acute Myocardial Infarction
Authors: Aslanabadi Naser , Mashayekhi Sina , Rezvani Maziar , Abdollahzadeh Ali , Hajialigol Amirhossein 
Published: November 2024

ABSTRACTIntroductionThe benefit of complete revascularization in diabetic patients with myocardial infarction remains unclear. this study aims to find the optimal strategy of total vascular repair for diabetic patients with acute myocardial infarction.MethodsIn an analysis of a cohort, we assigned diabetic patients with myocardial infarction who were undergoing percutaneous coronary intervention (PCI) of the culprit lesion to receive either staged complete revascularization of nonculprit lesions or to receive no further revascularization in Madani Hospital (Tabriz, Iran). Functionally significant nonculprit lesions were identified either by angiography. The primary outcome was rates of readmission, cardiac deaths, nonfatal myocardial re‐infarction, and overall mortality at 1 year.ResultsIn our center, a total of 1186 patients underwent primary‐PCI treatment, among which 521 were diagnosed with diabetes. Ultimately, 393 patients were selected for inclusion in the study. Within this cohort, 271 individuals (68.9%) underwent repair of only the culprit vessels (group 1), while 122 individuals (31.1%) received a comprehensive staged restoration of the vessels (group 2). During this time, group 1 in comparison with group 2 experienced 204 (75.3%) versus 97 (79.5%) cases of readmission, 48 (17.7%) versus 8 (6.5%) instances of cardiac death, 22 (8.1%) versus 18 (14.7%) occurrences of nonfatal myocardial re‐infarction. Notably, the incidence of cardiac death in group 2 were significantly lower than that in group 1 (p ≤ 0.05).ConclusionsFor individuals diagnosed with diabetes, staged complete revascularization demonstrated a lower frequency of readmission, cardiac deaths, nonfatal myocardial reinfarction, and overall mortality, in contrast to revascularization that targeted only the culprit lesion.
Solvent Free Ambient Pressure CO2 Cycloaddition Catalyzed by Cobalt‐Impregnated 2D‐Nanofibrous COFs
Authors: Ullah Habib , Ullah Zakir , Khattak Zafar A. K. , Tahir Muhammad , Kang Eunji , Verpoort Francis , You Kim Hyun 
Published: November 2024

AbstractCovalent organic frameworks (COFs) constitute an evolving class of permanently porous and ordered materials, and they have recently attracted increased interest due to their intriguing morphological features and numerous applications in gas storage, adsorption, and catalysis. However, their low aqueous stabilities and tedious syntheses generally hamper their use in heterogeneous catalysis. Nonetheless, a capable and water‐stable heterogeneous catalytic system for coupling CO2/epoxides to generate industrially important cyclic carbonates is still of great interest. Herein, exceedingly water‐ and thermally stable 2D‐cobalt‐impregnated hydrazone‐linked fibrous COFs are reported as a catalyst for CO2/epoxide coupling reactions at ambient pressure. The functionalized cobalt (Co)‐doped COFs demonstrated excellent catalytic activities with the high TONs (80925) and TOFs (6466 h−1), outperforming reported heterogeneous catalysts for CO2/epoxide coupling at ambient pressure. We found that the Co2+ ions within the COF matrix catalyze CO2 cycloaddition through density functional theory calculations. We also confirmed the excellent structural stability and consistent activity of Co‐doped COFs up to ten repeating cycles.
Offset Compensation Network: Improving the Control of Battery Energy Storage Systems
Authors: Costa Amorim Álvaro Lúcio , Santos Peixoto Bárbara , Fagner Cupertino Allan , Martins Stopa Marcelo , Augusto Pereira Heverton , Teodorescu Remus 
Published: November 2024

ABSTRACTRecently, battery energy storage systems (BESS) have gained importance due to the growing introduction of intermittent renewable energy power plants. Although BESS already has multiple applications, the current standard approach presents several drawbacks aggravated by the second‐life batteries use. In order to deal with this issue, the literature proposes the integration of dc/dc converters in the batteries, an approach known as smart battery. However, due to the different capacities of the batteries, the conventional control of smart battery packs does not guarantee a constant dc‐link voltage, because during operation, some dc/dc converters can reach their physical voltage limit. Therefore, this paper proposes an algorithm called offset compensation network (OCN) that guarantees constant dc‐link voltage even when there are saturated converters. Simulations in software PLECS and hardware‐in‐the‐loop experiments validate the proposal. The results prove the improvement of the technology as the possibility to operate with fixed dc‐link voltage, enabling the use of second‐life batteries, OCN algorithm reduces the SOC balancing time in 6.25% and avoids dc‐link voltage variations during the balancing process. Finally, this technology is fully compatible with current power conversion systems, allowing an easy retrofit of standard BESS.
Improved identification of clinically relevant Acute Leukemia subtypes using standardized EuroFlow panels versus non‐standardized approach
Authors: Terra Rafik , Éthier Vincent , Busque Lambert , Morin‐Quintal Ariane , D'Angelo Giovanni , Hébert Josée , Wang Xuehai , Lépine Guylaine , LeBlanc Richard , Bergeron Julie 
Published: November 2024

AbstractRare acute leukemia (AL) components or subtypes such as blastic plasmacytoid dendritic cell neoplasm (BPDCN) or early T‐cell precursor acute Lymphoblastic Leukemia (ETP‐ALL) can be difficult to detect by routine flow cytometry due to their immunophenotypes overlapping with other poorly differentiated AL. We hypothesized that using standardized EuroFlow™ Consortium approach could better diagnose such entities among cases that previously classified as acute myeloid leukemia (AML)‐M0, AML with minimal differentiation, AML with myelodysplasia‐related changes without further lineage differentiation, and AL of ambiguous lineage. In order to confirm this hypothesis and assess whether these AL subtypes such as BPDCN and ETP‐ALL had previously gone undetected, we reanalyzed 49 banked cryopreserved sample cases using standardized EuroFlow™ Consortium panels. We also performed target sequencing to capture the mutational commonalities between these AL subtypes. Reanalysis led to revised or refined diagnoses for 23 cases (47%). Of these, five diagnoses were modified, uncovering 3 ETP‐ALL and 2 typical BPDCN cases. In 12 AML cases, a variable proportion of immature plasmacytoid dendritic cell and/or monocytic component was newly identified. In one AML case, we have identified a megakaryoblastic differentiation. Finally, in five acute lymphoblastic leukemia (ALL) cases, we were able to more precisely determine the maturation stage. The application of standardized EuroFlow flow cytometry immunophenotyping improves the diagnostic accuracy of ALs and could impact treatment decisions.