bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and biological significance of adamantinomatous craniopharyngioma with CTNNB1 mutation
Authors: Hara Takuma , Akutsu Hiroyoshi , Takano Shingo , Kino Hiroyoshi , Ishikawa Eiichi , Tanaka Shuho , Miyamoto Hidetaka , Sakamoto Noriaki , Hattori Keiichiro , Sakata-Yanagimoto Mamiko , Chiba Shigeru , Hiyama Takashi , Masumoto Tomohiko , Matsumura Akira 
Published: August 2018

OBJECTIVEThe Wnt/β-catenin signaling pathway is strongly implicated in the pathogenesis of adamantinomatous craniopharyngioma (adaCP). However, there is no evidence that the CTNNB1 mutation activates the target gene of Wnt/β-catenin signaling, and it is unknown whether it affects the tumorigenesis of adaCP. To assess the effect of the CTNNB1 mutation of adaCP, the authors analyzed the correlation between the mutation and clinical, radiological, pathological, and biological findings.METHODSBetween 2003 and 2015, 42 patients (24 male and 18 female, median age 42 years) with either papillary craniopharyngioma (papCP) or adaCP underwent tumor resection at the authors’ institution. BRAF V600E and CTNNB1 in papCP and adaCP samples were sequenced by next-generation sequencing and the Sanger method, and mRNA expression levels of Axin2 and BMP4 were evaluated by RT-PCR. Axin2, BMP4, β-catenin, and BRAF expression were evaluated by immunohistochemistry. Other data were collected from clinical reports.RESULTSThe BRAF V600E mutation was detected in all 10 cases of papCP (100%). CTNNB1 exon 3 mutations were detected in 21 of 31 (68%) cases of adaCP, excluding 1 case for which there were no available sequence data. The mRNA expression level of Axin2 was significantly higher in adaCPs with a CTNNB1 mutation than in those without (p < 0.05). The immunohistochemical findings of Axin2 and BMP4 did not correlate with CTNNB1 mutation positivity. When patients who received adjuvant radiation therapy were excluded, progression-free survival was shorter in the mutation-positive group than in the mutation-negative group (log-rank test, p = 0.031). Examination of clinical characteristics and immunohistochemical findings of adaCPs showed that there was no significant correlation between CTNNB1 mutation positivity and age, sex, tumor volume, gross-total resection, optic tract edema, calcification, or T1 signal intensity of cyst fluid on MRI, β-catenin, and MIB-1 index.CONCLUSIONSThese results raise the possibility that the CTNNB1 mutation in adaCP may be associated with disease recurrence, and genes related to the Wnt/β-catenin signaling pathway might represent a therapeutic target.
Interfacility neurosurgical transfers: an analysis of nontraumatic inpatient and emergency department transfers with implications for improvements in care
Authors: Safaee Michael M. , Morshed Ramin A. , Spatz Jordan , Sankaran Sujatha , Berger Mitchel S. , Aghi Manish K. 
Published: August 2018

OBJECTIVEInterfacility neurosurgical transfers to tertiary care centers are driven by a number of variables, including lack of on-site coverage, limited available technology, insurance factors, and patient preference. The authors sought to assess the timing and necessity of surgery and compared transfers to their institution from emergency departments (ED) and inpatient units at other hospitals.METHODSAdult neurosurgical patients who were transferred to a single tertiary care center were analyzed over 12 months. Patients with traumatic injuries or those referred from skilled nursing facilities or rehabilitation centers were excluded.RESULTSA total of 504 transferred patients were included, with mean age 55 years (range 19–92 years); 53% of patients were women. Points of origin were ED in 54% cases and inpatient hospital unit in 46%, with a mean distance traveled for most patients of 119 miles. Broad diagnosis categories included brain tumors (n = 142, 28%), vascular lesions, including spontaneous and hypertensive intracerebral hemorrhage (n = 143, 28%), spinal lesions (n = 126, 25%), hydrocephalus (n = 45, 9%), wound complications (n = 29, 6%), and others (n = 19, 4%). Patients transferred from inpatient units had higher rates of surgical intervention (75% vs 57%, p < 0.001), whereas patients transferred from the ED had higher rates of urgent surgery (20% vs 8%, p < 0.001) and shorter mean time to surgery (3 vs 5 days, p < 0.001). Misdiagnosis rates were higher among ED referrals (11% vs 4%, p = 0.008). Across the same timeframe, patients undergoing elective admission (n = 1986) or admission from the authors’ own ED (n = 248) had significantly shorter lengths of stay (p < 0.001) and ICU days (p < 0.001) than transferred patients, as well as a significantly lower total cost ($44,412, $46,163, and $72,175, respectively; p < 0.001).CONCLUSIONSThe authors present their 12-month experience from a single tertiary care center without Level I trauma designation. In this cohort, 65% of patients required surgery, but the rates were higher among inpatient referrals, and misdiagnosis rates were higher among ED transfers. These data suggest that admitting nonemergency patients to local hospitals may improve diagnostic accuracy of patients requiring urgent care, more precisely identify patients in need of transfer, and reduce costs. Referring facilities may lack necessary resources or expertise, and the Emergency Medical Treatment and Active Labor Act (EMTALA) obligates tertiary care centers to accept these patients under those circumstances. Telemedicine and integration of electronic medical records may help guide referring hospitals to pursue additional workup, which may eliminate the need for unnecessary transfer and provide additional cost savings.
Blunt vertebral artery injury in occipital condyle fractures
Authors: Burks Joshua D. , Conner Andrew K. , Briggs Robert G. , Bonney Phillip A. , Smitherman Adam D. , Baker Cordell M. , Glenn Chad A. , Ghafil Cameron A. , Pryor Dillon P. , O’Connor Kyle P. , Bohnstedt Bradley N. 
Published: August 2018

OBJECTIVEA shifting emphasis on efficient utilization of hospital resources has been seen in recent years. However, reduced screening for blunt vertebral artery injury (BVAI) may result in missed diagnoses if risk factors are not fully understood. The authors examined the records of blunt trauma patients with fractures near the craniocervical junction who underwent CTA at a single institution to better understand the risk of BVAI imposed by occipital condyle fractures (OCFs).METHODSThe authors began with a query of their prospectively collected trauma registry to identify patients who had been screened for BVAI using ICD-9-CM diagnostic codes. Grade and segment were recorded in instances of BVAI. Locations of fractures were classified into 3 groups: 1) OCFs, 2) C1 (atlas) fractures, and 3) fractures of the C2–6 vertebrae. Univariate and multivariate analyses were performed to identify any fracture types associated with BVAI.RESULTSDuring a 6-year period, 719 patients underwent head and neck CTA following blunt trauma. Of these patients, 147 (20%) had OCF. BVAI occurred in 2 of 43 patients with type I OCF, 1 of 42 with type II OCF, and in 9 of 62 with type III OCF (p = 0.12). Type III OCF was an independent risk factor for BVAI in multivariate modeling (OR 2.29 [95% CI 1.04–5.04]), as were fractures of C1–6 (OR 5.51 [95% CI 2.57–11.83]). Injury to the V4 segment was associated with type III OCF (p < 0.01).CONCLUSIONSIn this study, the authors found an association between type III OCF and BVAI. While further study may be necessary to elucidate the mechanism of injury in these cases, this association suggests that thorough cerebrovascular evaluation is warranted in patients with type III OCF.
Intraoperative intracranial pressure monitoring in the pediatric craniosynostosis population
Authors: Judy Brendan F. , Swanson Jordan W. , Yang Wuyang , Storm Phillip B. , Bartlett Scott P. , Taylor Jesse A. , Heuer Gregory G. , Lang Shih-Shan 
Published: August 2018

OBJECTIVEEvaluation of increased intracranial pressure (ICP) in the pediatric craniosynostosis population based solely on ophthalmological, clinical, and radiographic data is subjective, insensitive, and inconsistent. The aim of this study was to examine the intraoperative ICP before and after craniectomy in this patient population.METHODSThe authors measured the ICP before and after craniectomy using a subdural ICP monitor in 45 children. They regulated end-tidal carbon dioxide and the monitoring site under general anesthesia to record consistent ICP readings.RESULTSThe average age of the patient population was 29 months (range 3.8–180.5 months). Thirty-seven patients (82.2%) were undergoing initial craniosynostosis procedures. All craniosynostosis procedures were categorized as one of the following: frontoorbital advancement (n = 24), frontoorbital advancement with distraction osteogenesis (n = 1), posterior vault distraction osteogenesis (n = 10), and posterior vault reconstruction (n = 10). Nineteen of 45 patients (42.2%) had syndromic or multisuture craniosynostosis. The mean postcraniectomy ICP (8.8 mm Hg, range 2–18 mm Hg) was significantly lower than the precraniectomy ICP (16.5 mm Hg, range 6–35 mm Hg) (p < 0.001). Twenty-four patients (53%) had elevated ICP prior to craniectomy, defined as ≥ 15 mm Hg. Only 4 (8.9%) children had papilledema on preoperative funduscopic examination (sensitivity 17%, specificity 100%, negative predictive value 51%, and positive predictive value 100%). There were no significant differences in elevated precraniectomy ICP based on type of craniosynostosis (syndromic/multisuture or nonsyndromic) or age at the time of surgery. Patients undergoing initial surgery in the first 12 months of life were significantly less likely to have elevated precraniectomy ICP compared with patients older than 12 months (26.3% vs 73.1%, p = 0.005).CONCLUSIONSIn this study, the authors report the largest cohort of syndromic and nonsyndromic craniosynostosis patients (n = 45) who underwent precraniectomy and postcraniectomy ICP evaluation. A craniectomy or completed craniotomy cuts for distractors effectively reduced ICP in 43/45 patients. The authors’ findings support the notion that papilledema on funduscopy is a highly specific, however poorly sensitive, indicator of increased ICP, and thus is not a reliable screening method. These findings indicate that even nonsyndromic patients with craniosynostosis are at risk for increased ICP. Furthermore, patients who present prior to 12 months of age appear less likely to have elevated ICP on presentation. Further studies with other noninvasive imaging of the retina may be useful as an adjunct tool for determining elevated ICP.
SISTEM SAMBUNGAN KONSTRUKSI RUMAH TRADISIONAL DI KAMPUNG PULO, JAWA BARAT
Authors: Harapan Andi 
Published: August 2018

Abstract: Kampong Pulo in West Java has a unique characteristic of it’s traditional building that can be showed the building shape, material and joint system, which be divided into lower system, middle system, and upper system. The lower system is included the foundation (included column untuk floor) and floor, the middle system is included wall frame, door & window, and the upper system is included ceiling (and its frame) and roof. Based on this reaseach we found that traditional building in Kampong Pulo is not depends on theory and principle of building but adjusting it with the circumstance and climate around it.The observation is focused on three building aspects: form and configuration, material and dimension, and detail of joint system for all the building system (lower, middle, and upper). This observation created to map construction joint system for traditional building in Kampong Pulo, West Java Keywords: Kampong Pulo, joint system of construction, traditional house, West Java. Abstrak: Bangunan rumah tradisional di Kampung Pulo, Jawa Barat mempunyai karakteristik yang unik, yang dapat dilihat dari sistem konstruksi bangunannya, yang meliputi sistem bagian bawah, tengah dan atas. Bagian bawah meliputi fondasi dan lantai, bagian tegah meliputi rangka dinding, pintu dan jelndela, sedangkan bagian atas meliputi langit-langit dan atap. Pembahasan penelitian dilihat dari tiga aspek, yaitu: aspek bentuk dan konfigurasi, material dan dimensi, detail sistem sambungan konstruksi. Karakteristik dari bangunan tradisional yakni tidak menerapkan teori atau prinsip bangunan akan tetapi menyesuaikan dengan lingkungan dan iklim yang ada. Dari penelitian ini dapat membuka ruang pengembangan sistem sambungan konstruksi yang dapat diterapkan pada bangunan sederhana terutama yang menggunakan struktur dan konstruksi kayu dan memberikan ruang untuk pengembangan bangunan-bangunan tradisional yang dilindungi/diproteksi oleh Pemda setempat khususnya Jawa Barat terhadap keberadaan sistem sambungan tradisional. Kata Kunci: Kampung Pulo, sistem sambungan konstruksi, rumah tradisional, Jawa Barat.
Mikrofabrikasi Jalur PCB Menggunakan Metode Visible Ligth Maskless Photolitography
Authors: Suwandi Dedi , Badruzzaman Badruzzaman , Istiyanto Jos 
Published: August 2018

Pada tulisan ini akan dibahas metode modifikasi dari Photolitography yaitu Visible Ligth Maskless Photolitography, perbedaannya menggunakan sinar tampak (visible light) dan tanpa mask (cetakan) selanjutnya diaplikasikan pada fabrikasi jalur listrik PCB (printed circuit board). [DI1]Kelebihan metode adalah mudah, murah tetapi mampu membuat profil rumit dan aman. Cara kerjanya model/ profil dibuat di komputer/ laptop kemudian dipancarkan melalui DLP projector. Pada bagian bawah projector dipasang PCB yang sudah dilapisi Negative Photoresist sehingga terjadi proses exposure. Selanjutnya dilakukan proses developing dan eching sehingga terbentuk profil sesuai desain. Pada jenis projector Infocus IN114A ditemukan parameter terbaik: posisi lensa pemfokus pembesaran 3X berjarak 3 cm dibawah DLP projektor dan 14 cm diatas material uji PCB, menggunakan kombinasi warna hitam (R:0 G:0 B:0) dan biru terang (R=0, G=176, B=240) dengan waktu prebake 2 menit, spin 2.000 rpm, exposure 3 menit, developing 5 menit, Postbake 5 menit dan Eching 5 menit. Profil jalur listrik yang berhasil dibuat diantaranya: garis, huruf, alur listrik, dan bentuk microcontroller. Hasil pengukuran Scanning Electron Microscope (SEM) profil garis terkecil yang dapat dibuat yaitu m132 m dan memiliki kekasaran tepi (deviasi) 6,6 m.
Studi Eksperimen Konversi LPG Pada Sepeda Motor Berbahan Bakar Bensin
Authors: Nur Rohmat Yusup 
Published: August 2018

Tingginya pertumbuhan jumlah kendaraan bermotor serta konsumsi bahan bakar minyak di Indonesia telah menimbulkan masalah terhadap lingkungan dan penyedian bahan bakar ini. Permasalahan ini makin rumit karena [A1]subsidi untuk pengadaannya sangat memberatkan Anggaran Pendapatan dan Belanja Negara. Oleh karena itu harus terus dilakukan upaya komprehensif untuk mencari solusi terbaiknya. Dalam makalah ini dibahas hasil penelitian yang bertujuan untuk mengurangi emisi dan menurunkan konsumsi bahan bakar sepeda motor, dengan mengkonversi penggunaan bahan bakar bensin dengan LPG yang biasa digunakan untuk memasak. Pengujian dilakukan di laboratorium menggunakan dinamometer chassis untuk membandingkan torsi, daya, tingkat konsumsi bahan bakar serta biaya operasi, pada sebuah mesin sepeda motor berkarburator menggunakan bahan bakar bensin dan LPG, baik tanpa pengubahan kondisi pengapian maupun dengan mengubah kondisi pengapian. Dari penelitian ini didapatkan bahwa bahan bakar LPG memiliki unjuk kerja yang baik dan dapat digunakan secara langsung tanpa mengubah kondisi pengapiannya. Akan tetapi kinerjanya akan lebih baik jika kondisi pengapiannya disesuaikan. Tingkat konsumsi terbaik LPG adalah 86 km/kg atau senilai Rp.58/km sedangkan bensin 66 km/l atau Rp.98/km.
Rancang Bangun Pagar Otomatis dengan Finger Print Berbasis Mikrokontroller
Authors: Usman Usman , Abdul Azis Rahmansyah Abdul , Fajri Apriadi Nur 
Published: August 2018

The fence is one of the leading security in maintaining a building. Conventional fence require operator to open and close it, so it does not effective and efficient. This problem can be solved with automated systems. This research aims to design fance system using finger print sensor based microcontroller arduino, which is equipped with a locking system that use a solenoid. This experimental research is starts from the design, fabrication and testing. Fences made have specifications 3.2 m x 1.5 m with a total weight is 30.67 kg, path lengthis 2.1 m, diameter sprocket 0.03 m, Voltage DC motor is 12 V and rotation is 195 rpm. The test results showed a good performance conform with its initial design, where a fence can be opened with a fingerprint has been recorded before. Solenoid can open and lock, likewise with the the photodiode can detect object is on the track. The test results obtained there are differences when opening / closing compared with the results design is 20%, with an average voltage is 12.06 V, current is 1 A, rotation is 135 rpm, and the time it takes 9.9 s, where the torque produced is of 0.64 Nm and maximum load can be driven by a DC motor is at 59.97 kg.
OPTIMASI TEMPERATUR INTERFACE PADA PELAPISAN ULANG NI-HARD 1 DENGAN METODE GRAVITY CASTING
Authors: Hanaldi Kus , Purwadi Wiwik , Kurnia Nurzaenal Friya 
Published: August 2018

Grinding roll is one type of product made by the method of bimetallic casting. The product consists of two types of material that held together with foundry process. Grinding roll has two kinds of different material properties, outer grinding roll should be hard because it would destroy the mine or rock with material hardness at 9.3 mohs. The inside of the grinding roll should be soft, for machining process , and also for dampen the vibration caused by the grinding process. In use, the outer layer of the grinding roll will be thinned. The purpose of this study to fix the beam Ni-Hard 1 by coating using a material Ni-Hard 1 with variable temperature liquid interface. The methodology of this study is the beam of Ni-Hard 1 to be coated (called die blank) is heated by the flow of liquid metal Ni Hard1. This process is called flushing. The volume of flushing fluid is accommodated at the disposal basin. The design, which has been determined, simulated using software (solidcast 8.2) to determine the temperature of interface, and then carried out experiments in the workshop.The bond was analyzed by testing the microstructure, composition, and hardness. Results from this study is the technology to coat Ni-Hard 1 with material Ni-Hard 1 that bonding occurs at the surface. Results of research showed that surface fixing with gravity casting method can be applied at Grinding roll, with the temperature variable interface that must be achieved between 887 ° C – 1198 ° C, flushing time between 10-20 seconds, with a pouring temperature of 1438 ° C – 1468 ° C.
Performance and Economic Analysis of Solar Water Pump System Laboratory Scale
Authors: Usman Usman , Sunding Alang , Parawangsa Akbar Naro 
Published: August 2018

The dependence of solar radiation in generating electricity by PV will have an impact on the PVWPS performance, besides The PVWPS consists many components with different characteristics. Thus this research will investigation the performance conduct economic analysis of PVWPS. To achieve that objective measurement of data starting at 09.00 until 16.00. The data are solar radiation, voltage and current of PV/pump and the time required to fill the container with a certain volume. Analysis data is using the equations that have been predetermined and comparison other research. The results obtained that the water discharge generated by PVWPS will be proportional to solar radiation, as a result the production of electricity generated by PV. The pump efficiency and system is proportional to solar radiation. This phenomenon is the effect of water debit dependence on solar radiation. The result of economic analysis is the price of electricity generated by SPATS is relatively cheap and the water cost for every m3 is inversely proportional to the water discharge generated by the pump.
Degradación fotocatalítica de la orto y meta-Nitroanilina en un reactor cilíndrico – parabólico compuesto
Authors: Diaz Prada Wilberth Daniel , Cortes Hernández Héctor Fabio , Rodríguez Espinosa Jhon Alexander 
Published: August 2018

Catalytic photodegradation with solar radiation is one of the most economical and highly useful technologies in advanced oxidation processes for the treatment of contaminants in water. The technique uses semiconductors that take advantage of a percentage of the wavelength emitted by the sun for the generation of species pair hollow-electron, that initiate the conversion of the molecules to be degraded. In the present research the photodegradation of the ortho and meta-Nitroaniline systems is studied in a solar reactor fitted with a compound Parabolic Collector (CPC) built at microscale, using TiO2 as a catalyst in suspension. The optimum conditions were determined in terms of solution flow rate, species derived from the acid and type of oxidizing agent. The results reveal a higher percentage of degradation with the use of hydrogen peroxide regardless of the flow rate for both compounds and an acceptable water quality under biological analysis on species guppies (Poecilia reticulata).
Study of Bacterial Pathogens in Urinary Tract Infection and their Antimicrobial Sensitivity Pattern
Authors: Parveen Rezina , Rahim Ina 
Published: August 2018

Background: Urinary tract infection (UTI) is one of the most common bacterial infections in Bangladesh. Antimicrobial agents are used for its treatment. The increase in antibiotic resistance among uropathogens is a global problem.Objective: This study was designed to find out the prevalence of UTI, its causative agents and their antimicrobial susceptibility patterns among suspected patients of UTI attending Dhaka Dental College Hospital, Dhaka.Methodology: This cross-sectional study was carried out in Dhaka Dental College Hospital, Dhaka during the period of November 2014 to May 2017. Clinically diagnosed cases of UTI irrespective of age and sex from out-patient department and in-patient department were selected for the purpose of the study. For culture, the urine samples were inoculated on 5% sheep blood agar and MacConkey’s agar media using calibrated loop following standard bacteriological technique. After the incubation period, the plate were examined for bacterial pathogen. The disk diffusion method (Kirby Bauer’s) was used to determine the antimicrobial susceptibility of isolates. Standard inoculums were inoculated on Mueller-Hinton agar and incubated at 37oC for 24 hours.Result: Ninety three urine samples were studied. Among the 93 samples most of them were in the age group of 21 to 30 years. Out of 93 samples, 26 (27.95%) samples were found culture positive. Escherichia coli (92.30%) was found to be the predominant organism. Regarding antimicrobial sensitivity pattern Esch. coli was found to be most sensitive to Imipenem (100%), Amikacin (87.5%), and Nitrofurantoin (83.33%).Conclusion: In conclusion young aged female are commonly suffering from UTI and Escherichia coli is the most common isolated bacteria.Bangladesh Journal of Infectious Diseases, December 2017;4(2):40-44