bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liver Fibrosis Assessment in a Cohort of Greek HIV Mono-Infected Patients by Non-Invasive Biomarkers
Authors: Androutsakos Theodoros , Schina Maria , Pouliakis Abraham , Kontos Athanasios , Sipsas Nikolaos , Hatzis Gregorios 
Published: September 2019

Background:
Non-alcoholic Fatty Liver Disease (NAFLD) is common in HIV-infected
individuals. Liver biopsy remains the gold-standard procedure for the diagnosis of liver fibrosis, but
both Transient Elastography (TE) and Non-invasive Biomarkers (NIBMs) have emerged as alternatives.

Objectives:
Our study’s aim was to validate commonly used NIBMs for the assessment of liver fibrosis
in a cohort of Greek HIV-mono-infected patients.

Methods:
Inclusion criteria were confirmed HIV-infection and age>18 years and exclusion criteria
HBV or HCV seropositivity, liver disease other than NAFLD, alcohol abuse, ascites, transaminases
levels>4xULN(upper limit of normal) and Body-Mass index(BMI)>40. Liver stiffness (LS) measurement
with TE and thorough laboratory work up and medical history were acquired at study entry.
FIB-4, APRI, NFS, BARD, Forns and Lok scores were calculated for each patient.

Results:
A total of 157 patients were eligible for this study. Significant liver fibrosis, compatible
with Metavir score of F3-F4, was found in only 11(7%) patients. These findings were in accordance
with those of the NIBMs; the BARD score constituting the only exception, allocating 102(65%) patients
as having significant liver fibrosis. In order to obtain a balance between sensitivity and specificity
new cut-offs for each NIBM were calculated; FIB-4 score yielded the best results, since by
changing the cut-off to 1.49 a sensitivity and specificity balanced for both close to 85% was
achieved.

Conclusions:
Our findings suggest that NIBMs can be used for the evaluation of liver fibrosis in HIV
mono-infected patients. New cut-offs for NIBMs should probably be calculated, to help distinguishing
patients with significant from those with mild/no fibrosis.
Determination of Dysregulated miRNA Expression Levels by qRT-PCR after the Application of Usnic Acid to Breast Cancer
Authors: Tanman Ümmügülsüm , Yangın Sevcan , Cansaran-Duman Demet 
Published: September 2019

Background and Purpose:
Breast cancer still remains to be one of the most threatening cancer types
in women. Recent studies have allowed scientists to better investigate the potential use of natural compounds in
the treatment of breast cancers. Usnic acid is a secondary metabolite extracted from lichen species and has many
biological activities. The response of microRNAs regulated by drug molecules may provide useful diagnostic
and prognostic biomarkers, as well as potential therapeutics for breast cancers. Although the aberrant expression
of microRNAs was observed after drug treatment, the regulatory mechanisms remain partially known. Micro
RNAs (miRNAs) play an important role in gene regulation at the post-transcriptional level.

Methods:
In this study, we used quantitative Real-Time PCR (qRT-PCR) technology to demonstrate that usnic
acid significantly changes the expression profile of miRNAs.

Results:
Eleven miRNAs were significantly and differentially expressed in breast cancer cells after treatment
with usnic acid. Three miRNAs were up-regulated, while eight were down-regulated in usnic acid treated cells.
Target prediction and GO analysis revealed many target genes and their related pathways that are potentially
regulated by usnic acid regulated differentially expressed miRNAs. We found that usnic acid treatment caused
significant changes in the expression of hsa-miR-5006-5p, hsa-miR-892c-3p, hsa-miR-4430, hsa-miR-5194,
hsa-miR-3198, hsa-miR-3171, hsa-miR-933 and hsa-miR-185-3p in breast cancer cells.

Conclusions:
Usnic acid response miRNAs might play important regulatory roles in the tumorigenesis and
development of breast cancer, and they could serve as prognostic predictors for breast cancer patients.
Diabetes Is Associated With Worse Long-term Outcomes in Young Adults After Myocardial Infarction: The Partners YOUNG-MI Registry
Authors: Divakaran Sanjay , Singh Avinainder , Biery David , Yang Junjie , DeFilippis Ersilia M. , Collins Bradley L. , Ramsis Mattheus , Qamar Arman , Hainer Jon , Klein Josh , Cannon Christopher P. , Polk Donna M. , Plutzky Jorge , Nasir Khurram , Januzzi James L. , Di Carli Marcelo F. , Bhatt Deepak L. , Blankstein Ron 
Published: September 2019

OBJECTIVE
We sought to determine the prevalence of diabetes and associated cardiovascular outcomes in a contemporary cohort of young individuals presenting with their first myocardial infarction (MI) at age ≤50 years.

RESEARCH DESIGN AND METHODS
We retrospectively analyzed records of patients presenting with a first type 1 MI at age ≤50 years from 2000 to 2016. Diabetes was defined as a hemoglobin A1c ≥6.5% (48 mmol/mol) or a documented diagnosis of or treatment for diabetes. Vital status was ascertained for all patients, and cause of death was adjudicated.

RESULTS
Among 2,097 young patients who had a type 1 MI (mean age 44.0 ± 5.1 years, 19.3% female, 73% white), diabetes was present in 416 (20%), of whom 172 (41%) were receiving insulin. Over a median follow-up of 11.2 years (interquartile range 7.3–14.2 years), diabetes was associated with a higher all-cause mortality (hazard ratio 2.30; P &lt; 0.001) and cardiovascular mortality (2.68; P &lt; 0.001). These associations persisted after adjusting for baseline covariates (all-cause mortality: 1.65; P = 0.008; cardiovascular mortality: 2.10; P = 0.004).

CONCLUSIONS
Diabetes was present in 20% of patients who presented with their first MI at age ≤50 years and was associated with worse long-term all-cause and cardiovascular mortality. These findings highlight the need for implementing more aggressive therapies aimed at preventing future adverse cardiovascular events in this population.
Komunikasi Organisasi Bidang Reservasi Hotel
Authors: Panuju Redi , Narena I Kadek 
Published: September 2019

Bali tourism is growing rapidly even though there was a decline due to bomb terror and Mount Agung's increased activity. This tourism development is followed by the rapid growth of the hospitality business to support the provision of accommodation services. Each hotel has particular employee who will make it easier for guests to make reservations. Reservations employee have a very complex task that must be considered in order to provide the best service. In general, organizational communication in the Pullman Bali Legian Beach (PBLB) Hotel Reservation (HR) Department has so far run well, but there are things that should be improved if the work appreciation or career level & communication climate needs to be improved related to the factors that influence work motivation. This study uses a qualitative approach. Data obtained by in-depth interviews with key informants from HR in PBLB. Based on the analysis results, it is known that the communication styles used are very diverse ranging from controlling, structured, two-way and very dynamic communication styles. The communication climate at the PBLB reservation office is also good. So far, the communication skills from the reservation team is considered good, and they also realize it is the main capital to carry out their profession as a reservation employee. Pariwisata Bali berkembang pesat meski sempat terjadi penurunan akibat teror bom dan aktifitas Gunung Agung yang meningkat. Perkembangan pariwisata ini diikuti dengan berkembang pesatnya bisnis perhotelan untuk membantu menunjang penyediaan jasa akomodasi. Setiap hotel memiliki karyawan reservasi yang mempermudah tamu untuk melakukan pemesanan. Karyawan bidang reservasi memiliki tugas yang sangat kompleks mengingat banyak hal yang harus diperhatikan guna memberikan pelayanan yang terbaik. Secara umum komunikasi organisasi dibidang Reservasi Hotel Pullman Bali Legian Beach (PBLB) sejauh ini berjalan baik namun ada hal-hal yang perlu ditingkatkan, seperti apresiasi kerja atau jenjang karir dan iklim komunikasi terkait faktor yang mempengaruhi motifasi kerja. Penelitian ini menggunakan pendekatan kualitatif. Data diperoleh dengan wawancara mendalam terhadap informan kunci dari SDM bidang Reservasi. Berdasarkan hasil analisis diketahui gaya komunikasi yang di pakai sangatlah beragam mulai dari gaya komunikasi mengendalikan, terstruktur, dua arah dan sangat dinamis. Iklim komunikasi di kantor reservasi PBLB juga baik. Sejauh ini terlihat kemampuan berkomunikasi dari tim reservasi baik dan merekapun menyadari itu sebagai modal utama menjalani profesi mereka sebagai seorang karyawan bidang reservasi hotel.
BEYOND RESEARCH COOPERATION ON SUCCESSFUL AGING: COMPARATIVE ANALYSIS OF THE COGNITIVE PERFORMANCE OF ELDERLY PEOPLE IN BRAZIL AND FINLAND
Authors: Santos Geraldine Alves dos , Sanerma Päivi 
Published: September 2019

ABSTRACTMany studies have been carried out, mainly in the last decades, to understand the normal and pathological process of aging in the different areas of knowledge. However, many gaps still remain in the progress of science. In this sense, the overall objective of the present study was to evaluate the comparison between the performance of congruent elderly people in Brazil and Finland. The study method had a quantitative, descriptive cross - sectional design. The sample consisted of 194 subjects of both sexes, aged between 60 and 79 years, residing in the municipality of Ivoti / Rio Grande do Sul / Brazil and 93 subjects, both genders aged 65 to 85 years residing in Riihimäki / Finland. The instrument used was the Mini Mental State Examination (MMSE). Data were analyzed statistically in SPSS version 25.0 through descriptive analysis of frequency and comparison of means by the Mann Whitney test (p≤0.05). The results showed that the cognitive performance of elderly people in the Ivoti group was significantly higher than those of Riihimäki. It can be concluded that cultural variables influenced outcomes, such as experiences in the early stages of human development and current interpersonal relationships.Keywords: Cognitive performance. Successful aging. Elderly. RESUMOMuitos estudos têm sido realizados, principalmente nas últimas décadas, para compreender o processo normal e patológico de envelhecimento, nas diferentes áreas do conhecimento. Entretanto, muitas lacunas ainda se mantêm presentes no progresso da ciência. Neste sentido, o objetivo geral do presente estudo foi avaliar a comparação entre o desemepnho congitivo de pessoas idosas residentes no Brasil e na Finlândia. O método do estudo teve um delineamento quantitativo, descritivo e transversal. A amostra compreendeu 194 sujeitos, de ambos os sexos, com idade entre 60 e 79 anos, residentes no município de Ivoti/Rio Grande do Sul/Brasil e 93 sujeitos, de ambos os sexos com idade entre 65 e 85 anos residentes em Riihimäki/Finlândia. O instrumento utilizado foi o Mini Exame do Estado Mental (MEEM). Os dados foram analisados estatisticamente no programa SPSS versão 25.0 através de análises descritivas de frequência e de comparação de médias pelo teste Mann Whitney (p≤0,05). Os resultados demonstraram que o desempenho cognitivo das pessoas idosas do grupo de Ivoti foi significativamente maior que os de Riihimäki. Pode-se concluir que variáveis culturais influenciaram os resultados, tais como experiências nas fases iniciais do desenvolvimento humano e as relações interpessoais atuais.Palavras-chave: Desempenho cognitivo. Velhice. Idosos.
Analisis Hubungan Gaya Hidup dengan Kualitas Hidup Wanita Pasangan Subur Akseptor KB IUD
Authors: Prastika Bella Putri Sinta , Pradine Retnayu , Armini Ni Ketut Alit 
Published: September 2019

Penggunaan KB IUD yang rendah dapat mempengaruhi kualitas hidup keluarga. Semakin rendah penggunaan kontrasepsi maka semakin rendah kualitas hidup. Berbagai faktor termasuk gaya hidup yang diterapkanÂ diduga mempengaruhi kualitas hidupÂ akseptor KBÂ IUD. Tujuan penelitian iniÂ menjelaskan hubungan gaya hidup dengan kualitas hidup wanita pasangan subur akseptor KB IUD. Metode: Desain penelitian iniÂ korelasional dengan pendekatan cross-sectional. Populasi dalam penelitian ini adalah 120 akseptor KB IUD di Wilayah Kerja Puskesmas Mulyorejo Surabaya. BesarÂ sampel 92Â wanita usia subur akseptorÂ KB IUD diperolehÂ denganÂ purposive sampling, dengan kriteria inklusi wanita usia subur 18-40 tahun, tinggal serumah dengan suami dan dapat berkomunikasi secara lisan dan verbal. Variabel independen gaya hidup. Variabel dependenÂ kualitas hidup. Pengumpulan data menggunakan kuesioner gaya hidup dari Prihatiningsih dan kualitas hidup WHOQOL-BREF yang telah diterjemahkan untuk kualitas kehidupan dari WHO. Uji statistik dengan Spearmanâ€™s rho test. Hasil: Tidak hubungan signifikan antara gaya hidup dengan kualitas hidup (p=0,960, r=0,005). Pembahasan: Gaya hidup responden sebagian besar adalah gaya hidup sehat. Faktor gaya hidup yang berhubungan dengan kualitas hidup adalah aktivias fisik, lingkungan, perilaku konsumtif, dan managemen strees. Hal ini tidak bisa menjadi patokan untuk meningkatkan kualitas hidup seseorang. Karena gaya hidup sehat tidak selalu penyumbang terbesar pada kualitas hidup, tapi ada faktor lain yang perlu diperhatikan. Karena dari hasil penelitian di dapatkan responden lebih mandiri, jadi tidak membutuhkan gaya hidup yang cukup untuk meningkatkan kualitas hidupnya. Perlu dilakukannya penelitian lebih lanjut tentang faktor lain yang berhubungan kualitas hidup akseptorÂ KB.
ANALISIS BERITA POLITIK PADA SURAT KABAR HARIAN (SKH) KEDAULATAN RAKYAT TENTANG PEMBERANTASAN KORUPSI DI ERA PEMERINTAHAN JOKOWI-JK
Authors: Risnawati Ririn 
Published: September 2019

This study examines the Political News Analysis of the Sovereignty of the People's Sovereignty on Eradicating Corruption as the Independence of the Mass Media in Proclaiming the Performance of the Jokowi-JK Government which focuses on 1 year of its administration (20 October 2014 October 20 2015). This research is based on two things, namely: first, how is the analysis of the political news regarding Corruption Eradication in the local mass media (Kedaulatan Rakyat) in reporting on the performance of the Jokowi-JK government; second, how the independence of the local mass media in reporting on the performance of the Jokowi-JK government in the area of ??corruption eradication. Media independence is seen from the method of Qualitative Approach with Critical Paradigm namely Critical Discourse Analysis; using Teun A. van Dijk's Model Analysis of text production involving aspects of cognition and social context. The production of text in the political news regarding the Eradication of Corruption in Judging the Performance of the Jokowi-JK Government presented by the Kedaulatan Rakyat SKH is a strong text structure. The Kedaulatan Rakyat Daily Newspaper is able to provide detailed Semantic Structure and more coherent relationships between words / sentences. In addition, the Kedaulatan Rakyat Daily Newspaper minimizes graphics and metaphor as rhetorical elements so as to be able to present more real and factual news. starting from text, social cognition and social context. The news on SKH Kedaulatan Rakyat is able to present the factual news objectivity in accordance with the truth and relevance. Not only that, the objectivity of the news about justice is able to be fulfilled by the People's Sovereignty SKH by presenting balanced news and explaining it more neutral without the support of the mass media.
Keywords: Political News, Independence, Mass Media, Eradication of Corruption
Enhancing shared decision making about discontinuation of antidepressant medication: a concept-mapping study in primary and secondary mental health care
Authors: Wentink Carolien , Huijbers Marloes J , Lucassen Peter LBJ , van der Gouw Annoek , Kramers Cornelis , Spijker Jan , Speckens Anne EM 
Published: September 2019

BackgroundThe apparent rise of antidepressant use seems to be explained to a large extent by an increase in long-term use. Both professionals and patients appear reluctant to discontinue antidepressant medication (ADM). It is not known what factors determine this reluctance.AimThis study aimed to identify factors that enable the shared decision-making process about discontinuation of ADM between long-term users and their GPs.Design and settingConcept-mapping study of a purposive sample of both patients and professionals from primary and secondary mental health care in the Netherlands.MethodConcept mapping was used to conceptualise and structure the topics relevant to the discontinuation process from the perspective of both patients and professionals. Participants generated topics in brainstorming sessions and subsequently prioritised and sorted them. Multidimensional scaling and hierarchical cluster analyses were used for the cluster topics.ResultsThirty-seven patients and 27 professionals generated 50 separate topics. Hierarchical cluster analysis revealed six clusters of topics: ‘Process of discontinuation’, ‘Expectations’, ‘Professional guidance’, ‘Current use’, ‘Environment’, and ‘Side effects’. Patients and professionals came up with largely similar topics. Nevertheless, a difference was found between these groups regarding the perceived importance of professional guidance.ConclusionThis study yielded an informed selection of the topics that seem most important to discuss when considering whether to discontinue ADM. As perspectives of both patients and professionals were combined, the topics may provide patients and GPs with a broader and more balanced scope of factors to consider, and thus facilitate a better shared decision-making process.
Size Effect of Graphene Nanoparticles on the Thermal Properties of the Doped Phase Change Materials
Authors: TEMEL Ümit Nazlı , ERDİŞ Eyüp 
Published: September 2019

In this study, the size effects of the Graphene
nanoparticles (GNP) doped into a paraffin type organic phase change material
(PCM) on thermal properties were examined. The thermal conductivities,
melting/solidification temperatures and melting/solidification latent heats of
the GNP/PCM composites, which were obtained by incorporating GNP nanoparticles
with three different sizes into an organic PCM in mass fractions of 1%, 3% and
5%, were measured. The changes obtained in thermal properties were determined by
referring to the non-doped PCM data. The results obtained showed that in low
PCM mass fractions, thermal conductivity enhancement was a function of both
surface area and thickness of the GNP nanoparticles. In addition, it was
determined that thicker nanoparticles formed a more efficient conduction
network at high PCM fractions. The reflections of the enhancements obtained in
thermal conductivity on thermal performance were also determined in the study. Enhancements in thermal
conductivity depending on the increase in thickness of GNP were obtained as 6.3%,
107.5% and 113.7% for 5% GNP(1-5nm)/ PCM, 5% GNP(6-8nm)/PCM and 5% GNP(11-15nm)/PCM
composites, respectively. These thermal conductivity enhancements resulted
performance increase in the energy storage unit around 5.5%, 18.3% and 20%
respectively.
Imagen metalingüística: una propuesta para la escritura de correspondencia en la clase de redacción técnica en español
Authors: Souza Rita Rodrigues 
Published: September 2019

Resumen: En este artículo, se expone una propuesta didáctica de uso de imágenes para la escritura de correspondencia en sala de clase de español, específicamente, en la asignatura de Redacción Técnica en el Curso Técnico en Secretariado en la modalidad de Educación de Jóvenes y Adultos. El artículo busca resaltar el valor de los estudios de género textual, del análisis de necesidades y del uso de imágenes en el contexto formal de educación. Así, el artículo pretende discutir la importancia de las imágenes visuales como recurso didáctico en las clases de español como lengua extranjera en la escrita de correspondencias personales en la enseñanza técnica. Imagen Metalingüística. Géneros textuales. Educación de Jóvenes y Adultos. Resumo: Neste artigo, expõe-se uma proposta didática de uso de imagens para a escrita de correspondência em sala de aula de espanhol, especificamente, na disciplina de Redação Técnica no Curso Técnico em Secretariado na modalidade de Educação de Jovens e Adultos. O artigo busca ressaltar a importância dos estudos de gênero textual, da análise de necessidades e do uso de imagens no contexto formal de educação. Assim, o seguinte artigo pretende discutir o uso das imagens visuales como recurso didático nas aulas de espanhol como língua estrangeira com ênfase na produção escrita de cartas pessoais no ensino técnico.
HUBUNGAN ANTARA PENGETAHUAN DENGAN KECEMASAN IBU POST SECTIO CAESAREA TENTANG MOBILISASI DINI (Di RSU Muslimat Kabupaten Ponorogo)
Authors: Darmayanti Rofik , Nurfauzia Arina Ulfa 
Published: September 2019

Persalinan merupakan peristiwa penting dan mulia. Pada umumnya, para ibu pasca melahirkan takut melakukan banyak gerakan karena merasa khawatir gerakan-gerakan yang dilakukan akan menimbulkan dampak yang tidak diinginkan, sehingga ibu memilih bermalas-malasan hanya berbaring sepanjang waktu, namun ibu yang telah melahirkan perlu mendapatkan perawatan sebaik-baiknya salah satunya dengan menganjurkan ibu melakukan mobilisasi dini terutama pada persalinan sectio caesarea. Tujuan penelitian ini adalah mengetahui hubungan antara pengetahuan dengan kecemasan ibu post sectio caesarea tentang mobilisasi dini di RSU Muslimat Kabupaten Ponorogo.
Desain penelitian adalah korelasional. Pendekatannya menggunakan cross sectional. Pengambilan sampel menggunakan Accidental, Populasinya adalah semua ibu post sectio caesarea sejumlah 30. sehingga seluruh populasi digunakan menjadi sampel. Variable penelitian terdiri dari 2 variabel yaitu variable independen berupa pengetahuan ibu post sectio caesarea tentang mobilisasi dini dan dependen berupa kecemasan ibu post sectio caesarea tentang mobilisasi dini. Pengmumpulan data melalui editing, coding, scoring, tabulating. Untuk menguji kesesuaian dengan menggunakan analisa Spearman Rank.
Hasil penelitian menunjukan pengetahuan cukup dengan kecemasan ringan pada ibu post sectio caesarea berjumlah (46,67%), dan pada ibu yang pengetahuan cukup dengan kecemasan ringan berjumlah 10 esponden (33,33%). Berdasarkan hasil uji statistik dengan tingkat signifikan 5%, didapatkan Rs hitung­ 0,579 dan ­Rs tabel 0,361, maka H1 diterima. Artinya ada hubungan antara pengetahuan tentang mobilisasi dini dengan tingkat kecemasan ibu post secetio caesarea tentang mobilisasi dini.
Berdasarkan hasil penelitian pengetahuan ibu dapat mempengaruhi adanya kecemasan. Sehingga diharapkan adanya perhatian dan dukungan dari keluarga. Tenaga kesehatan sekitar juga diharapkan agar mensosialisasikan secara menyeluruh pengetahuan tentang mobilisasi dini post sectio caesarea.