bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of natural rubber elastomeric bridge bearing pad compound formula on various curing systems
Authors: Puspitasari S , Andriani W , Cifriadi A 
Published: August 2019

Abstract
Commercial elastomeric bridge bearing (EBB) pad is dominated by the laminated type. Laminated EBB pad comprises of rubber composite layers which are arranged intermittently among the thin steel plates. The rubber composite uses natural rubber or chloroprene synthetic rubber as the base elastomer. Local EBB pad industries mostly produce natural rubber bridge bearing pad type due to the enormous availability of natural rubber in Indonesia. However, the quality of natural rubber bridge bearing pad product often cannot fulfil the standard requirement in compression set and accelerated aging parameters. The research studied the design of EBB pad compound formula based on natural rubber type. The EBB compound formulas were prepared by varring the curing system such as sulphur (efficient and semi-efficient) and peroxide curing system. Designing the compound formula was in accordance to the methods required in improving the compression set and accelerating aging quality of natural rubber bridge bearing pad. The result of curing characteristic of the natural rubber bridge bearing pad compound showed that peroxide curing system gave the longest optimum curing time. Further, sulphur curing system produced high crosslink density followed with good mechanical properties of natural rubber bridge bearing pad vulcanizate. The compression set value of natural rubber bridge bearing pad vulcanizates which were obtained by efficient and semi-efficient curing systems as 14.09% and 24.81%, respectively were regarded to be below the maximum requirement (25%). The peroxide curing system was not recommended due to the high compression set value of 40.68%. Meanwhile, maximum percent changes of tensile properties and retention values which indicated accelerated aging parameter of natural rubber bridge bearing pads were formed either by sulphur and peroxide curing system could fulfilled the standard requirement of EBB Duro 70 refered to SNI 3967:2013.
Effect of concomitant vancomycin and piperacillin–tazobactam on frequency of acute kidney injury in pediatric patients
Authors: Buhlinger Kaitlyn M , Fuller Kathryn A , Faircloth Cassidy B , Wallace Jessica R 
Published: August 2019

Abstract

Purpose
Results of a study of rates of acute kidney injury (AKI) in pediatric patients treated with vancomycin plus piperacillin–tazobactam or vancomycin plus alternative antipseudomonal β-lactams (APBLs) are reported.

Methods
A retrospective, single-center cohort study was performed. Pediatric patients were included in the study cohort if they received combination therapy for at least 48 hours, had documented baseline and follow-up serum creatinine levels, and had a documented serum vancomycin trough concentration. The primary outcome was the frequency of AKI, defined as a 50% or greater increase in serum creatinine concentration from baseline or an increase of at least 0.5 mg/dL from baseline. The secondary outcome was time to AKI onset.

Results
A total of 474 patients were included. Among 100 patients who received vancomycin plus piperacillin–tazobactam, the rate of AKI was higher than the rate in the group treated with vancomycin plus alternative APBLs (27% versus 7%, p < 0.0001). The median time to AKI onset was shorter in the piperacillin–tazobactam group versus the alternative APBL group (3.8 versus 7.9 days, p = 0.0065). Patients who were administered piperacillin–tazobactam were almost 6 times as likely to develop AKI (odds ratio [OR], 5.955; 95% confidence interval [CI], 2.774–12.784), and patients who had a maximum vancomycin trough concentration greater than 20 mg/L were 7.5 times as likely to develop AKI (OR, 7.552; 95% CI, 3.625–15.734).

Conclusion
Pediatric patients treated with concomitant vancomycin and piperacillin–tazobactam had a higher rate of AKI, with faster AKI onset, than those who received vancomycin in combination with other APBLs.
HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling
Authors: Hu Han , Jiang Mingyang , Cao Yangpo , Zhang Zhuojun , Jiang Bin , Tian Feng , Feng Juan , Dou Yali , Gorospe Myriam , Zheng Ming , Zheng Lemin , Yang Zhongzhou , Wang Wengong 
Published: August 2019

Abstract

Aims
The elevated expression of phospholamban (PLB) has been observed in heart failure and cardiac remodelling, inhibiting the affinity of Ca2+ pump to Ca2+ thereby impairing heart relaxation. However, the mechanisms underlying the regulation of PLB remains to be further studied. The present study aims to test the role of RNA-binding protein HuR in the regulation of PLB and the impact of this regulatory process in cardiac remodelling.

Methods and results
A mouse model specifically deleted HuR in cardiomyocytes were used for testing the role of HuR in regulating PLB during isoproterenol (ISO)-induced cardiac remodelling. HuR deficiency did not significantly influence the phenotype and function of mouse heart under static status. However, deletion of HuR in cardiomyocytes mitigated the effect of ISO in inducing PLB expression and reducing β1-AR expression, in turn aggravating ISO-induced myocardial hypertrophy and cardiac fibrosis. In H9C2 cells, association of HuR with PLB and β1-AR mRNAs stabilized PLB mRNA and destabilized β1-AR mRNA, respectively.

Conclusion
HuR stabilizes PLB mRNA and destabilizes β1-AR mRNA. The HuR-PLB and HuR-β1-AR regulatory processes impact on ISO-induced cardiac remodelling.
Avian Binocularity and Adaptation to Nocturnal Environments: Genomic Insights from a Highly Derived Visual Phenotype
Authors: Borges Rui , Fonseca João , Gomes Cidália , Johnson Warren E , O’Brien Stephen J , Zhang Guojie , Gilbert M Thomas P , Jarvis Erich D , Antunes Agostinho 
Published: August 2019

AbstractTypical avian eyes are phenotypically engineered for photopic vision (daylight). In contrast, the highly derived eyes of the barn owl (Tyto alba) are adapted for scotopic vision (dim light). The dramatic modifications distinguishing barn owl eyes from other birds include: 1) shifts in frontal orientation to improve binocularity, 2) rod-dominated retina, and 3) enlarged corneas and lenses. Some of these features parallel mammalian eye patterns, which are hypothesized to have initially evolved in nocturnal environments. Here, we used an integrative approach combining phylogenomics and functional phenotypes of 211 eye-development genes across 48 avian genomes representing most avian orders, including the stem lineage of the scotopic-adapted barn owl. Overall, we identified 25 eye-development genes that coevolved under intensified or relaxed selection in the retina, lens, cornea, and optic nerves of the barn owl. The agtpbp1 gene, which is associated with the survival of photoreceptor populations, was pseudogenized in the barn owl genome. Our results further revealed that barn owl retinal genes responsible for the maintenance, proliferation, and differentiation of photoreceptors experienced an evolutionary relaxation. Signatures of relaxed selection were also observed in the lens and cornea morphology-associated genes, suggesting that adaptive evolution in these structures was essentially structural. Four eye-development genes (ephb1, phactr4, prph2, and rs1) evolved in positive association with the orbit convergence in birds and under relaxed selection in the barn owl lineage, likely contributing to an increased reliance on binocular vision in the barn owl. Moreover, we found evidence of coevolutionary interactions among genes that are expressed in the retina, lens, and optic nerve, suggesting synergetic adaptive events. Our study disentangles the genomic changes governing the binocularity and low-light perception adaptations of barn owls to nocturnal environments while revealing the molecular mechanisms contributing to the shift from the typical avian photopic vision to the more-novel scotopic-adapted eye.
Heat stress during the luteal phase decreases luteal size but does not affect circulating progesterone in gilts1
Authors: Bidne Katie L , Romoser Matthew R , Ross Jason W , Baumgard Lance H , Keating Aileen F 
Published: August 2019

Abstract
Heat stress (HS) occurs when heat dissipation mechanisms are insufficient to maintain euthermia, and it is associated with seasonal infertility (SI), which manifests as smaller litters, longer wean-to-estrus interval, increased abortions, and reduced conception rates. To understand HS-induced mechanisms underlying SI, crossbred post-pubertal gilts (167 ± 10 kg; n = 14) experienced either thermal neutral (TN, 20 ± 1 °C, n = 7) or cyclical HS (35 ± 1 °C for 12 h and 31.6 °C for 12 h, n = 7) conditions from 2 to 12 d post-estrus (dpe). Estrous cycles were synchronized via altrenogest administration for 14 d, phenotypic manifestation of estrus was observed and gilts were assigned to experimental treatment. Gilts were limit fed 2.7 kg daily with ad libitum water access. Blood was collected at 0, 4, 8, and 12 dpe via jugular venipuncture and animals were humanely euthanized at 12 dpe. The corpora lutea (CL) width were measured via digital calipers on both ovaries, and CL from one ovary were excised, weighed, and protein and steroid abundance analyzed via western blotting and ELISA, respectively. Relative to TN, HS increased (P < 0.01) rectal temperature and respiration rates and reduced (P < 0.01) feed intake. The CL from HS ovaries were reduced in diameter (P < 0.05) and weight (P < 0.01) relative to those from TN animals. No difference (P = 0.38) in CL or serum progesterone concentrations between groups was observed at any time point, though at 12 dpe the serum progesterone:CL weight was increased (P < 0.10) by HS. No treatment differences (P = 0.84) in circulating insulin were observed. Luteal protein abundance of steroid acute regulatory protein, 3 beta-hydroxysteroid, or prostaglandin F2α receptor were not different between treatments (P = 0.73). Taken together, these data demonstrate that the CL mass is HS sensitive, but this phenotype does not appear to be explained by the metrics evaluated herein. Regardless, HS-induced decreased CL size may have important implications to pig SI and warrants additional attention.
Reported County-Level Distribution of the American Dog Tick (Acari: Ixodidae) in the Contiguous United States
Authors: Lehane Aine , Parise Christina , Evans Colleen , Beati Lorenza , Nicholson William L , Eisen Rebecca J 
Published: August 2019

AbstractIn the United States, tick-borne diseases are increasing in incidence and cases are reported over an expanding geographical area. Avoiding tick bites is a key strategy in tick-borne disease prevention, and this requires current and accurate information on where humans are at risk for exposure to ticks. Based on a review of published literature and records in the U.S. National Tick Collection and National Ecological Observatory Network databases, we compiled an updated county-level map showing the reported distribution of the American dog tick, Dermacentor variabilis (Say). We show that this vector of the bacterial agents causing Rocky Mountain spotted fever and tularemia is widely distributed, with records derived from 45 states across the contiguous United States. However, within these states, county-level records of established tick populations are limited. Relative to the range of suitable habitat for this tick, our data imply that D. variabilis is currently underreported in the peer-reviewed literature, highlighting a need for improved surveillance and documentation of existing tick records.
Autonomy and Aesthetic Engagement
Authors: Nguyen C Thi 
Published: August 2019

Abstract
There seems to be a deep tension between two aspects of aesthetic appreciation. On the one hand, we care about getting things right. Our attempts at aesthetic judgments aim at correctness. On the other hand, we demand autonomy. We want appreciators to arrive at their aesthetic judgments through their own cognitive efforts, rather than through deferring to experts. These two demands seem to be in tension; after all, if we want to get the right judgments, we should defer to the judgments of experts. How can we resolve this tension? The best explanation, I suggest, is that aesthetic appreciation is something like a game. When we play a game, we try to win. But often, winning isn’t the point; playing is. Aesthetic appreciation involves the same flipped motivational structure: we aim at the goal of correctness, but having correct judgments isn’t the point. The point is the engaged process of interpreting, investigating, and exploring the aesthetic object. When one defers to aesthetic testimony, then, one makes the same mistake as when one looks up the answer to a puzzle, rather than solving it for oneself. The shortcut defeats the whole point. This suggests a new account of aesthetic value: the engagement account. The primary value of the activity of aesthetic appreciation lies in the process of trying to generate correct judgments, and not in having correct judgments.
The unique case of the AGN core of M87: a misaligned low power blazar?
Authors: Lucchini M , Krauß F , Markoff S 
Published: August 2019

Abstract
M87 hosts one of the closest jetted active galactic nucleus (AGN) to Earth. Thanks to its vicinity and to the large mass of is central black hole, M87 is the only source in which the jet can be directly imaged down to near-event horizon scales with radio very large baseline interferometry (VLBI). This property makes M87 a unique source to isolate and study jet launching, acceleration and collimation. In this paper we employ a multi-zone model designed as a parametrisation of general relativistic magneto-hydrodynamics (GRMHD); for the first time we reproduce the jet’s observed shape and multi-wavelength spectral energy distribution (SED) simultaneously. We find strong constraints on key physical parameters of the jet, such as the location of particle acceleration and the kinetic power. However, we under-predict the (unresolved) γ-ray flux of the source, implying that the high-energy emission does not originate in the magnetically-dominated inner jet regions. Our results have important implications both for comparisons of GRMHD simulations with observations, and for unified models of AGN classes.
Achievements of Hinode in the first eleven years
Authors:   Hinode Review Team, Al-Janabi Khalid , Antolin Patrick , Baker Deborah , Bellot Rubio Luis R , Bradley Louisa , Brooks David H , Centeno Rebecca , Culhane J Leonard , Del Zanna Giulio , Doschek George A , Fletcher Lyndsay , Hara Hirohisa , Harra Louise K , Hillier Andrew S , Imada Shinsuke , Klimchuk James A , Mariska John T , Pereira Tiago M D , Reeves Katharine K , Sakao Taro , Sakurai Takashi , Shimizu Toshifumi , Shimojo Masumi , Shiota Daikou , Solanki Sami K , Sterling Alphonse C , Su Yingna , Suematsu Yoshinori , Tarbell Theodore D , Tiwari Sanjiv K , Toriumi Shin , Ugarte-Urra Ignacio , Warren Harry P , Watanabe Tetsuya , Young Peter R 
Published: August 2019

Abstract
Hinode is Japan’s third solar mission following Hinotori (1981–1982) and Yohkoh (1991–2001): it was launched on 2006 September 22 and is in operation currently. Hinode carries three instruments: the Solar Optical Telescope, the X-Ray Telescope, and the EUV Imaging Spectrometer. These instruments were built under international collaboration with the National Aeronautics and Space Administration and the UK Science and Technology Facilities Council, and its operation has been contributed to by the European Space Agency and the Norwegian Space Center. After describing the satellite operations and giving a performance evaluation of the three instruments, reviews are presented on major scientific discoveries by Hinode in the first eleven years (one solar cycle long) of its operation. This review article concludes with future prospects for solar physics research based on the achievements of Hinode.
Independent Association of Glucose Variability With Hospital Mortality in Adult Intensive Care Patients: Results From the Australia and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation Binational Registry
Authors: Kulkarni Hemant , Bihari Shailesh , Prakash Shivesh , Huckson Sue , Chavan Shaila , Mamtani Manju , Pilcher David 
Published: August 2019

Objectives:
Wide variations in blood glucose excursions in critically ill patients may influence adverse outcomes such as hospital mortality. However, whether blood glucose variability is independently associated with mortality or merely captures the excess risk attributable to hyperglycemic and hypoglycemic episodes is not established. We investigated whether blood glucose variability independently predicted hospital mortality in nonhyperglycemic critical care patients.

Design:
Retrospective, registry data analyses of outcomes.

Setting:
Large, binational registry (Australia and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation Adult Patient Database repository) of 176 ICUs across Australia and New Zealand.

Patients:
We used 10-year data on nonhyperglycemic patients registered in the Australia and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation Adult Patient Database repository (n = 290,966).

Interventions:
None.

Measurements and Main Results:
Glucose variability was captured using glucose width defined as the difference between highest and lowest blood glucose concentration within first 24 hours of ICU admission. We used hierarchical, mixed effects logistic regression models that accounted for ICU variation and several fixed-effects covariates. Glucose width was specifically and independently associated with hospital mortality. The association of blood glucose variability with mortality remained significant (odds ratio for highest vs lowest quartile of glucose, 1.43; 95% CI, 1.32–1.55; p < 0.001) even after adjusting for the baseline risk of mortality, midpoint blood glucose level, occurrence of hypoglycemia and inter-ICU variation. Mixed effects modeling showed that there was a statistically significant variation in this association across ICUs.

Conclusions:
Our study demonstrates that glucose variability is independently associated with hospital mortality in critically ill adult patients. Inclusion of correction for glucose variability in glycemic control protocols needs to be investigated in future studies.
Physician Judgment and Circulating Biomarkers Predict 28-Day Mortality in Emergency Department Patients*
Authors: Henning Daniel J. , Bhatraju Pavan K. , Johnson Nicholas J. , Kosamo Susanna , Shapiro Nathan I. , Zelnick Leila R. , Liles W. Conrad , Wurfel Mark M. 
Published: August 2019

Objectives:
To determine whether biomarkers of endothelial activation and inflammation provide added value for prediction of in-hospital mortality within 28 days when combined with physician judgment in critically ill emergency department patients.

Design:
Prospective, observational study.

Setting:
Two urban, academic emergency departments, with ≈80,000 combined annual visits, between June 2016 and December 2017.

Patients:
Admitted patients, greater than 17 years old, with two systemic inflammatory response syndrome criteria and organ dysfunction, systolic blood pressure less than 90 mm Hg, or lactate greater than 4.0 mmol/L. Patients with trauma, intracranial hemorrhage known prior to arrival, or without available blood samples were excluded.

Interventions:
Emergency department physicians reported likelihood of in-hospital mortality (0–100%) by survey at hospital admission. Remnant EDTA blood samples, drawn during the emergency department stay, were used to measure angiopoietin-1, angiopoietin-2, tumor necrosis factor receptor-1, interleukin-6, and interleukin-8.

Measurements and Main Results:
We screened 421 patients and enrolled 314. The primary outcome of in-hospital mortality within 28 days occurred in 31 (9.9%). When predicting the primary outcome, the best biomarker model included angiopoietin-2 and interleukin-6 and performed moderately well (area under the curve, 0.72; 95% CI, 0.69–0.75), as did physician judgment (area under the curve, 0.78; 95% CI, 0.74–0.82). Combining physician judgment and biomarker models improved performance (area under the curve, 0.85; 95% CI, 0.82–0.87), with area under the curve change of 0.06 (95% CI, 0.04–0.09; p < 0.01) compared with physician judgment alone.

Conclusions:
Predicting in-hospital mortality within 28 days among critically ill emergency department patients may be improved by including biomarkers of endothelial activation and inflammation in combination with emergency department physician judgment.
Low-cost thoracentesis simulation for nurse practitioner students
Authors: Talley Michele H. , Watts Penni 
Published: August 2019

ABSTRACTThe fast-paced hospital setting is not routinely a conducive environment for practicing procedural skills. Simulation learning can provide an opportunity for learners to achieve accuracy, confidence, and competence when performing the thoracentesis procedure. The cost associated with many commercial-brand manikins and the additional supplies needed to teach thoracentesis is expensive. However, thoracentesis is a skill many nurse practitioners (NPs) need to learn. The use of a whole, unstuffed turkey purchased at a supermarket to simulate a thoracentesis is a way in which NP students can safely practice this skill. Nurse practitioner students perform assessment skills on another student, whereas students perform the thoracentesis procedure on this turkey carcass. Nurse educators can teach NP students to safely, accurately, and efficiently perform a thoracentesis procedure using a low-cost simulator. Nurse educators can teach NP students how to perform a thoracentesis using a turkey carcass at a relatively low cost with a high yield.
Reducing chest radiography utilization in the medical intensive care unit
Authors: Wu Yu , Rose Mariah Q. , Freeman Michelle L. , Richard-Lany Nancy P. , Spaulding Aaron C. , Booth Sandra C. , Kelly Debra Lynch , Franco Pablo Moreno 
Published: August 2019

ABSTRACT

Background and purpose:
Daily chest radiographs (CXRs) have long been a routine part of care. However, evidence as well as changing technology has promoted on-demand CXRs as beneficial to patient care. We found that a substantial number of routine daily CXRs were being ordered, with some of the orders staying active even after extubation.

Methods:
Within a 19-bed adult medical ICU, we prospectively utilized 3 intervention phases from October 1, 2014, to February 28, 2018, to reduce routine CXRs. Nurse Practitioners (NP) initiated this quality improvement (QI) project, aiming to reduce the number of unnecessary of CXRs. Interventions included staff survey, routine CXR order removal, duplicate alerts, visual reminders, and an electronic clinical decision support tool. Monthly education of appropriate CXRs and bedside ultrasound were facilitated by NPs. The outcome measures of interest include: the number of CXRs per patient-day, the number of routine and on-demand CXRs, mortality rate, ICU length of stay, and ventilator days, radiation and cost.

Conclusions:
Total number of CXRs per patient-day decreased by 36.1%. The proportion of routine CXRs decreased from 55.37% to 13.18%; on-demand orders increased, from 44.63% to 86.82%; and calculated radiation-exposure per census decreased, from 0.011 to 0.008 mSv. In addition, charges to patients for CXRs decreased by $7,750/month. ICU mortality and ventilator days per census remained stable.

Implications for practice:
By an orchestrated process that included creating awareness and desire to change CXR ordering practices, we were able to decrease routine CXRs and increase on-demand utilization while maintaining counterbalance measures.