bluuebunny/crossref_metadata_2025_split huggingface dataset:
AUGMENT: A Phase III Study of Lenalidomide Plus Rituximab Versus Placebo Plus Rituximab in Relapsed or Refractory Indolent Lymphoma
Authors: Leonard John P. , Trneny Marek , Izutsu Koji , Fowler Nathan H. , Hong Xiaonan , Zhu Jun , Zhang Huilai , Offner Fritz , Scheliga Adriana , Nowakowski Grzegorz S. , Pinto Antonio , Re Francesca , Fogliatto Laura Maria , Scheinberg Phillip , Flinn Ian W. , Moreira Claudia , Cabeçadas José , Liu David , Kalambakas Stacey , Fustier Pierre , Wu Chengqing , Gribben John G. ,   for the AUGMENT Trial Investigators
Published: March 2019

PURPOSEPatients with indolent non-Hodgkin lymphoma typically respond well to first-line immunochemotherapy. At relapse, single-agent rituximab is commonly administered. Data suggest the immunomodulatory agent lenalidomide could increase the activity of rituximab.METHODSA phase III, multicenter, randomized trial of lenalidomide plus rituximab versus placebo plus rituximab was conducted in patients with relapsed and/or refractory follicular or marginal zone lymphoma. Patients received lenalidomide or placebo for 12 cycles plus rituximab once per week for 4 weeks in cycle 1 and day 1 of cycles 2 through 5. The primary end point was progression-free survival per independent radiology review.RESULTSA total of 358 patients were randomly assigned to lenalidomide plus rituximab (n = 178) or placebo plus rituximab (n = 180). Infections (63% v 49%), neutropenia (58% v 23%), and cutaneous reactions (32% v 12%) were more common with lenalidomide plus rituximab. Grade 3 or 4 neutropenia (50% v 13%) and leukopenia (7% v 2%) were higher with lenalidomide plus rituximab; no other grade 3 or 4 adverse event differed by 5% or more between groups. Progression-free survival was significantly improved for lenalidomide plus rituximab versus placebo plus rituximab, with a hazard ratio of 0.46 (95% CI, 0.34 to 0.62; P < .001) and median duration of 39.4 months (95% CI, 22.9 months to not reached) versus 14.1 months (95% CI, 11.4 to 16.7 months), respectively.CONCLUSIONLenalidomide improved efficacy of rituximab in patients with recurrent indolent lymphoma, with an acceptable safety profile.
Mutational Landscape in Resected Periampullary Adenocarcinoma: Relationship With Morphology and Clinical Outcome
Authors: Lundgren Sebastian , Hau Sofie Olsson , Elebro Jacob , Heby Margareta , Karnevi Emelie , Nodin Björn , Eberhard Jakob , Holm Karolina , Staaf Johan , Jönsson Göran B. , Jirström Karin 
Published: March 2019

PURPOSE Periampullary adenocarcinomas encompass a heterogeneous group of tumors with dismal prognosis and limited treatment options. Emerging evidence shows that tumor morphology (ie, intestinal type [I-type] or pancreatobiliary type [PB-type]) is a more relevant prognostic factor than tumor origin. Knowledge is sparse, however, on whether key mutations differ according to morphology. MATERIALS AND METHODS Next-generation sequencing was applied to assess the mutational status of 70 genes in 102 tumors from a retrospective cohort of 175 patients with resected periampullary adenocarcinoma. Brahma-related gene 1 protein expression was examined by immunohistochemistry on tissue microarrays with primary tumors from the original cohort. RESULTS APC mutations were significantly more common in I-type than in PB-type tumors (27.5% v 0%; P < .001), as were ERBB3 mutations (20.8% v 4.8%; P = .016), whereas CDKN2A mutations were more common in PB-type than in I-type tumors (19.4% v 2.5%; P = .013). KRAS mutation was an independent factor of poor prognosis in I-type tumors (hazard ratio, 3.73; 95% CI, 1.10 to 12.67). In PB-type tumors, SMARCA4 mutation was an adverse prognostic factor in patients not receiving adjuvant chemotherapy, and there was a significant treatment interaction between expression of Brahma-related gene 1 protein, the protein encoded by SMARCA4, and adjuvant chemotherapy ( Pinteraction = .007). CONCLUSION To our knowledge, this is the first description of the mutational landscape in the full spectrum of periampullary adenocarcinoma that demonstrates that the distribution and prognostic and predictive significance of commonly mutated genes differ by morphology. The results emphasize that morphology is an important factor to consider in the search for novel biomarkers and targeted personalized treatment of these patients. In addition, the findings support the concept that molecular profiling of these tumors could be of clinical benefit.
Investigation of the influence of a glutathione S-transferase metabolic resistance to pyrethroids/DDT on mating competitiveness in males of the African malaria vector, Anopheles funestus
Authors: Tchouakui Magellan , Tene Fossog Billy , Ngannang Brigitte Vanessa , Djonabaye Doumani , Tchapga Williams , Njiokou Flobert , Wondji Charles S. 
Published: March 2019

Background:Metabolic resistance is a serious challenge to current insecticide-based interventions. The extent to which it affects natural populations of mosquitoes including their reproduction ability remains uncharacterised. Here, we investigated the potential impact of the glutathione S-transferase L119F-GSTe2 resistance on the mating competitiveness of maleAnopheles funestus, in Cameroon.Methods:Swarms and indoor resting collections took place in March, 2018 in Tibati, Cameroon. WHO tube and cone assays were performed on F1mosquitoes from indoor collected females to assess the susceptibility profile of malaria vectors. Mosquitoes mated and unmated males collected in the swarms were genotyped for the L119F metabolic marker to assess its association with mating male competitiveness.Results: Susceptibility and synergist assays, showed that this population was multiple resistant to pyrethroids, DDT and carbamates, likely driven by metabolic resistance mechanisms. Cone assays revealed a reduced efficacy of standard pyrethroid-nets (Olyset and PermaNet 2.0) with low mortality (<25%) whereas synergist PBO-Nets (Olyset Plus and PermaNet 3.0) retained greater efficacy with higher mortality (>80%). The L119F-GSTe2 mutation, conferring pyrethroid/DDT resistance, was detected in thisAn. funestuspopulation at a frequency of 28.8%. In addition, a total of 15 mating swarms were identified and 21An. funestuscouples were isolated from those swarms. A comparative genotyping of the L119F-GSTe2 mutation between mated and unmated males revealed that heterozygote males 119L/F-RS were less able to mate than homozygote susceptible (OR=7.2, P<0.0001). Surprisingly, heterozygote mosquitoes were also less able to mate than homozygote resistant (OR=4.2, P=0.010) suggesting the presence of a heterozygote disadvantage effect. Overall, mosquitoes bearing the L119-S susceptible allele were significantly more able to mate than those with 119F-R resistant allele (OR=2.1, P=0.03).Conclusion:This study provides preliminary evidences that metabolic resistance potentially exerts a fitness cost on mating competiveness in resistant mosquitoes.
Creating High-Density Large Square Bales by Recompression
Authors: McAfee Joshua R. , Shinners Kevin J. , Friede Joshua C. , Walters Chase P. 
Published: March 2019

Abstract. Creating high-density biomass bales would reduce the number of bales handled, stored, and transported to biorefineries, thereby reducing costs. Recompression of large square bales is one approach to increase bale density; however, recompression research on large bales is limited. Recompression of common biomass crops in 80 cm × 90 cm nominal cross-section bales was used to quantify pressure-density and stress relaxation relationships as well as restraining forces required to maintain compressed densities. Linear, power, and exponential models were fit to the pressure-density data, with the linear model providing the best representation of the recompression process. When bales were recompressed soon after bale formation, density increased by an average of 134%, and the target dry-basis density of 205 kg m-3 was exceeded at the end of recompression with all crops. While still compressed, bales were wrapped with four steel cables configured with load cells to measure the restraining force after release of pressure followed by bale re-expansion. Total restraining forces ranged from 18 to 40 kN. Bale density decreased by an average of 17% due to re-expansion after pressure was released. Strain relief induced by allowing the bale to re-expand by approximately 10% before placing the cables around the bales reduced the required restraining force by an average of 35%. Although the forces applied were great (&gt;560 kN), the dry-basis specific energy requirements were comparatively low (0.18 to 0.29 kWh Mg-1) because recompression took place over a relatively long duration of approximately 20 to 25 s. Recompressing large square bales is a low-energy method to achieve bale densities that should ensure weight-limited biomass transport. Keywords: Bales, Biomass, Compression, Energy.
Understanding Decision Making Among Individuals With Intellectual and Developmental Disabilities (IDD) and Their Siblings
Authors: Burke Meghan M. , Lee Chung eun , Hall Sarah A. , Rossetti Zach 
Published: March 2019

Abstract
Many siblings anticipate fulfilling caregiving roles for their brothers and sisters with intellectual and developmental disabilities (IDD). Given these roles and the importance of supported decision making, it is crucial to understand how individuals with IDD and their siblings make decisions. Using dyadic interviews, we examined the perspectives of nine sibling dyads (N = 18) about decision making in relation to self-determination, independent living, and employment. The ages of participants ranged from 19 to 57. Data were analyzed using constant comparative analysis to identify themes. Decision making was characterized by: parents and siblings primarily identifying courses of action; the probability of respective consequences based on the person-environment fit; and the role of the sibling in making the final decision. Characteristics related to the individual with IDD, the family, the sibling, and the environment impacted decision making. Individuals with IDD were more likely to make their own decisions about leisure activities; however, siblings were more likely to make formal decisions for their brothers and sisters.
Active Support Training, Staff Assistance, and Engagement of Individuals With Intellectual and Developmental Disabilities in the United States: Randomized Controlled Trial
Authors: Qian Xueqin , Larson Sheryl A. , Tichá Renáta , Stancliffe Roger , Pettingell Sandra L. 
Published: March 2019

AbstractTwo non-U.S. quasi-experimental studies reported Active Support training was associated with increased engagement in individuals with IDD, but no randomized controlled trials (RCTs) exist. We evaluated effects of Active Support training on staff assistance, and social and nonsocial engagement in 75 individuals with intellectual and developmental disabilities (IDD) in U.S. group homes. We detected no significant effects of active support training. Individuals with more skills and less challenging behavior engaged more in nonsocial activities. Younger individuals with more skills living in homes with fewer staff changes were more socially engaged. Factors associated with nonsocial engagement mirrored those reported in Qian, Tichá, Larson, Stancliffe, & Wuorio, (2015). Staffing-related implementation challenges and statistical power limited our ability to detect differences.
#ADA25 Campaign: Using Social Media to Promote Participation, Social Inclusion, and Civic Engagement of People With Intellectual and Developmental Disabilities
Authors: Williamson Heather J. , Fisher Kim W. , Madhavni Devanshi , Talarico Lori 
Published: March 2019

Abstract
Social media is used for civic engagement and building social inclusion. Twitter is one social media tool that facilitates conversations on important societal events. A digital divide between the general population and people with intellectual and developmental disabilities (IDD) remains. Given the divide, we sought to understand the inclusion of the community of people with IDD in the conversations around the 25th anniversary of the Americans with Disabilities Act of 1990 (ADA). We conducted a content analysis of tweets associated with the anniversary and few tweets referenced the community of people with IDD. Our findings suggest that people with IDD are not included in larger civic conversations. Implications include targeted social media training for people with IDD and their support networks.
Intimate Relationships of People With Disabilities
Authors: Friedman Carli 
Published: March 2019

Abstract
Despite the difficulties people with disabilities may have garnering intimate relationships, intimate relationships may be particularly beneficial for people with disabilities as they result in greater self-acceptance, less internalized stigma, and more camaraderie. The aim of this study was to explore the intimate relationships of adults with disabilities (n = 1,443) in its many forms (from intimate friendships to romantic relationships). We particularly explored what factors increased the odds of adults with disabilities having intimate relationships, what supports resulted in increased likeliness to have intimate relationships, and what factors resulted in the presence of favorable intimate relationship outcomes. Our analysis revealed service organizations are key to enhancing the social and intimate relationships of adults with disabilities.
Vitamin C Dosis Rendah untuk Skorbut pada Thalassemia
Authors: Wahidiyat Pustika Amalia , Yosia Mikhael 
Published: March 2019

Belakangan ini beberapa pasien thalassemia mengeluhkan gusi berdarah, purpura dan nyeri disertai bengkak pada sendi. Kondisi berikut merupakan kondisi yang sangat serupa dengan tanda-tanda skorbut (kekurangan vitamin C). Sampai saat ini belum ada panduan pemberian vitamin C yang aman bagi pasien thalassemia (mengingat vitamin C dapat meningkatkan besi labil yang berbahaya pada pasien thalassemia). Tinjauan pustaka ini bertujuan untuk membahas informasi mengenai skorbut pada thalassemia disertai observasi manifestasi skorbut pada pasien thalassemia di seluruh dunia. Selain itu juga akan melihat kemungkinan pemberian suplemen vitamin C dosis rendah yang aman untuk mengatasi skorbut. Lima laporan kasus dengan total 7 kasus skorbut pada pasien thalassemia diikutkan dalam laporan ini[nc1] . Laporan kasus yang ditemukan berasal dari Sri Lanka, Kanada, Amerika Serikat dan India. Suplementasi vitamin C diberikan kepada semua kasus dengan dosis berkisar antara 50 mg/hari sampai 500 mg/hari. Semua keluhan hilang setelah pemberian vitamin C. Manifestasi klinis skorbut pada pasien thalassemia adalah gingivitis, perdarahan mukosa, nyeri dan kelemahan sendi dan purpura. Terapi [nc2] vitamin C dengan dosis rendah 50 mg/hari dapat menghilangkan keluhan klinis skorbut pada pasien thalassemia.
The rs7574865 polymorphism of the <i>STAT4</i> gene and risk of early rheumatoid arthritis development (the REMARKA study)
Authors: Guseva I. A. , Krylov M. Yu. , Demidova N. V. , Avdeeva A. S. , Smirnov A. V. , Samarkina E. Yu. , Luchina E. L. , Karateev D. E. , Nasonov E. L. 
Published: March 2019

The aim of the study was investigation of association of the rs7574865 polymorphism of STAT4 gene (Signal Transducer and Activator of Transcription 4, a family of signal transduction and transcription activation molecules 4) with very early rheumatoid arthritis (RA) in Russian patients, and the study of the relationship of "phenotype – genotype", particularly of positivity for antibodies to cyclic citrullinated peptides (ACCP), their concentration, the presence of erosive joint damage at inclusion in patients the study with the STAT4 gene polymorphism. Material and methods. The study was conducted in the framework of the program REMARKA (Russian study of Methotrexate and biological drugs in Early active Arthritis). 85 patients with very early RA with a duration of symptoms no more than 6 months, not receiving disease modifying anti-rheumatic drugs (DMARD) and biologicals were included. Results and discussion. The analysis of the distribution of genotypes and alleles of STAT4 rs7574865 polymorphism showed that the frequencies of g/G, G/T and T/T genotypes differ at the level of the prominent tendency to statistical significance between patients with RA and the control group (p=0.05). The frequency of minor allele T in RA is significantly higher than that in the control group, and this allele is associated with a predisposition to RA [odds ratio (OR) 1.7; 95% confidence interval (CI) 1.1–2.8; p=0.03]. In the study of the "genotype – phenotype" relationship, STAT4 gene polymorphism correlated with erosive joint damage (r2=0.289; p=0.008). In carriers of the homozygous genotype TT, the number of erosions at inclusion in the study was significantly higher compared with carriers of genotypes GG/GT (median 5.50 [0.754; 7.5] and 0.00 [0.00; 2.00], respectively; p=0.003). The risk of erosion is also associated with the polymorphism of the STAT4 gene (OR 8.6; 95% CI 1.0–204.9; p=0.03). A difference of the ACCP level depending on STAT4 gene polymorphism was revealed: carriers of at least one minor allele T (G/T+T/T) had significantly higher concentration of ACCP than that in carriers of homozygous GG genotype: 248.97±151.00 and 179.51±147.01 U/ml, respectively; p=0.048).Conclusion. The study showed that in Russian patients with very early RA, the STAT4 gene rs7574865 polymorphism is associated with both predisposition to the disease and prognostically unfavorable manifestations (phenotypes) of the disease, namely, with the development of erosion in the early stages of the disease and an increase of the ACCP level.
ANALISIS EFISIENSI EKONOMI PENGGUNAAN FAKTOR-FAKTOR PRODUKSI PADA USAHATANI JAMUR TIRAM DI DESA GENTING KECAMATAN JAMBU KABUPATEN SEMARANG
Authors: Puspitasari Vinisa Dyah , Prasetyo Edy , Setiyawan Heri 
Published: March 2019

Tujuan dari penelitian ini adalah untuk menganalisis pengaruh penggunaan faktor–faktor produksi terhadap produksi jamur tiram dan menganalisis efisiensi penggunaan faktor-faktor produksi pada usahatani jamur tiram di Desa Genting Kecamatan Jambu Kabupaten Semarang. Penelitian dilaksanakan pada bulan Desember 2016 di Desa Genting Kecamatan Jambu Kabupaten Semarang. Metode penelitian yang digunakan adalah metode survai. Sampel dalam penelitian ini ditentukan dengan metode sensus dengan jumlah responden 30 orang petani jamur tiram. Data dianalisis menggunakan analisis regresi linier berganda dengan fungsi produksi model Cobb-Douglas dan analisis efisiensi ekonomi penggunaan faktor-faktor produksi. Hasil penelitian menunjukkan bahwa faktor produksi yang berpengaruh terhadap produksi jamur tiram adalah luas lahan, serbuk kayu, bekatul dan tenaga kerja, sedangkan faktor produksi bibit dan kapur tidak berpengaruh nyata terhadap produksi jamur tiram. Penggunaan faktor produksi bibit, serbuk kayu, bekatul, kapur dan tenaga kerja secara ekonomi belum efisien, sedangkan penggunaan faktor produksi lahan secara ekonomi tidak efisien.Kata Kunci : efisiensi; faktor produksi; jamur tiram
FAKTOR-FAKTOR YANG MEMPENGARUHI TINGKAT PENGETAHUAN IBU RUMAH TANGGA TENTANG KONSEP DAGING SAPI YANG ASUH DI DESA BATURETNO KECAMATAN BATURETNO KABUPATEN WONOGIRI
Authors: Setyaningsih Evi , Gayatri Siwi , Eddy Bambang Trisetyo 
Published: March 2019

ABSTRAKTujuan penelitian ini adalah 1) mengetahui tingkat pengetahuan ibu rumah tangga tentang daging sapi yang ASUH. 2) menganalisis faktor-faktor yang mempengaruhi tingkat pengetahuan ibu rumah tangga terhadap konsep daging sapi yang ASUH. Penelitian ini dilaksanakan pada Februari 2017 sampai Maret 2017 di Desa Baturetno Kecamatan Baturetno Kabupaten Wonogiri. Metode penelitian ini adalah survai. Metode penentuan sampel menggunakan multistage random sampling dengan jumlah responden 97 orang ibu rumah tangga. Analisis data secara deskriptif dan regresi linier berganda. Hasil penelitian menunjukkan bahwa tingkat pengetahuan ibu rumah tangga termasuk dalam kriteria sedang. Hasil analisis menunjukkan secara signifikan faktor-faktor yang mempengaruhi tingkat pengetahuan ibu rumah tangga tentang konsep daging sapi yang ASUH adalah pendidikan, jumlah anggota keluarga, pendapatan keluarga, kesempatan memperoleh informasi dan keanggotaan dalam organisasi masyarakat, sedangkan variabel usia tidak berpengaruh secara signifikan.Kata Kunci: pengetahuan; ibu rumah tangga; daging sapi; ASUH
ANALISIS EFISIENSI EKONOMI PENGGUNAAN FAKTOR-FAKTOR PRODUKSI PADA USAHATANI KETELA POHON DI KECAMATAN TLOGOWUNGU KABUPATEN PATI
Authors: Luthfiah Arifatul , Mukson Mukson , Setiadi Agus 
Published: March 2019

ABSTRAKPenelitian ini dilakukan untuk menganalisis pengaruh jumlah penggunaan faktor-faktor produksi (luas lahan, bibit, pupuk organik, pupuk urea, pupuk phonska, pestisida dan tenagakerja) terhadap jumlah produksi usahatani ketela pohon dan menganalisis efisiensi ekonomi penggunaan faktor-faktor produksi pada usahatani ketela pohon di Kecamatan Tlogowungu Kabupaten Pati. Penelitian menggunakan metode survei. Metode penentuan lokasi penelitian ditentukan secara purposive (sengaja). Jumlah sampel dihitng menggunakan rumus Slovin dan diperoleh sebanyak 91 responden, sedangkan pengambilan sampel menggunakan metode simple random sampling. Metode analisis data menggunakan analisis fungsi produksi Cobb-Douglas yang kemudian ditransfomasi kedalam regresi linear berganda. Hasil penelitian menunjukkan bahwa secara serempak faktor produksi ketela pohon (luas lahan (X1), bibit (X2), pupuk organik (X3), pupuk urea (X4), pupuk phonska (X5), pestisida (X6) dan tenaga kerja (X7) berpengaruh nyata terhadap jumlah produksi ketela pohon. Penggunaan Faktor-faktor produksi luas lahan secara parsial berpengaruh sangat nyata, bibit dan pupuk phonska berpengaruh nyata terhadap produksi ketela pohon sedangkan pupuk organik, pupuk urea, pestisida dan tenaga kerja tidak berpengaruh terhadap jumlah produksi ketela pohon. Penggunaan lahan, bibit, pupuk organik, pupuk phonska dan pestisida belum mencapai efisiensi ekonomi sedangkan penggunaan faktor produksi pupuk urea dan tenaga kerja tidak efisien secara ekonomi.Kata Kunci: efisiensi ekonomi; faktor produksi; ketela pohon;usahatani
PENGARUH KINERJA BALAI PENYULUHAN PERTANIAN (BPP) DALAM PENERAPAN TEKNOLOGI PENGELOLAAN TANAMAN TERPADU (PTT) DAN PENINGKATAN PRODUKSI PADI DI KABUPATEN MAGELANG
Authors: Yunita Fitrin , Satmoko Sriroso , Roessali Wiludjeng 
Published: March 2019

This study aims to analyze the performance of agricultural extension centers, analyzing the application of PTT technology of rice, as well as analyzing the performance of Agricultural Extension Centers (BPP) in influencing the adoption of PTT and rice production in the district of Magelang. The basic method of research is quantitative descriptive survey approach. Exogenous variables in this study were BPP performance, while the endogenous variable is the adoption of PTT and rice production. The population in this study is 21 BPP in Magelang. The sampling technique used method purposive sampling. Respondents in this study a number of agricultural extension 148 and 148 farmers. Data collection techniques by observation and interviews. Analysis of the data used is Path Analysis. The results showed that the performance including the BPP in either category. Adoption PTT Rice in Magelang District including the high category. Production of rice in Magelang included in the category increased. BPP performance significantly influence farmers' adoption. Adoption PTT of Rice in Magelang Regency significantly affect rice production. BPP performance in Magelang significantly affect rice production. Increasing rice production would be done if supported by the performance of BPP and implementation optimal PTT of rice, the BPP's role should be improved through capacity building extension, the provision of infrastructure and funding to support the program in order to increase rice production, especially in the district of Magelang. Keywords: Agriculture Extension Centers (BPP); Adoption PTT of Rice; Production