bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functionally important binding site for a volatile anesthetic in a voltage-gated sodium channel identified by X-ray crystallography
Authors: Hollingworth David , Herold Karl F. , Kelly Geoff , Mykhaylyk Vitaliy B. , Xiang Jiaxin , Zhang Donghang , Wallace B. A. , Hemmings Hugh C. 
Published: November 2024

AbstractVolatile general anesthetics are used for inhalational anesthesia in hundreds of millions of surgical procedures annually, yet their mechanisms of action remain unclear. Membrane proteins involved in cell signaling are major targets for anesthetics, and voltage-gated ion channels that mediate neurotransmission, movement, and cognition are sensitive to volatile anesthetics (VAs). In many cases, the effects produced by VAs on mammalian ion channels are reproduced in prokaryotic orthologues, providing an opportunity to investigate VA interactions at high resolution using these structurally simpler prokaryotic proteins. We utilized the bacterial voltage-gated sodium channel (VGSC) NavMs fromMagnetococcus marinusto investigate its interaction with the widely used VA sevoflurane. Sevoflurane interacted directly with NavMs, producing effects consistent with multisite binding models for VA actions on their targets. We report the identification of one of these interactions at atomic detail providing the first high-resolution structure of a VA bound to a voltage-gated ion channel. The X-ray crystal structure shows sevoflurane binding to NavMs within an intramembrane hydrophobic pocket formed by residues from the voltage sensor and channel pore, domains essential for channel gating. Mutation of the dominant sevoflurane binding-site residue within this pocket, and analogous residues found in similar sites in human VGSCs, profoundly affected channel properties, supporting a critical role for this site in VGSC function. These findings provide the basis for future work to understand the role of VA interactions with VGSCs in both the anesthetic and toxic effects associated with general anesthesia.SignificanceWhile general anesthesia is an essential medical technique, the mechanisms that contribute to its pleiotropic neurological effects of unconsciousness, amnesia, immobility and analgesia remain incompletely understood. Identification of anesthetic binding sites in critical molecular targets like voltage-gated Na+channels is essential to elucidation of the mechanisms involved. Using a combined structural and functional approach, we identify and characterize the first known volatile anesthetic binding site in a voltage-gated ion channel.
Deforestation policies in the Brazilian Legal Amazon: an analysis of the PPCDAm using the triple difference method
Authors: Benevit Bruno , da Trindade Carolina Silva , de Melo Junior Roberto Bezerra , Uhr Daniel de Abreu Pereira , Uhr Julia Gallego Ziero 
Published: November 2024

PurposeThis study aims to evaluate the effects of the synergy between monitoring technologies and deforestation control policies promoted by the Action Plan for the Prevention and Control of Deforestation in the Legal Amazon (PPCDAm) during its initial stage.Design/methodology/approachThe triple difference method is employed to explore the differences between the non-metropolitan municipalities with Indigenous lands and other regional municipalities.FindingsThe findings indicate a reduction of approximately 16.1 km² per municipality between 2004 and 2007. This reduction corresponds to a decrease of 10,293 km² in the area of deforestation and a total of 498 million tons of CO2. To ensure the robustness of the results, placebo tests, event study and flexibility in the composition of the groups were conducted. The robustness tests substantiate the findings.Practical implicationsThese results emphasize the significance of remote monitoring policies for controlling deforestation in isolated regions and Indigenous lands. Additionally, such results indicate that the policy was cost-effective.Originality/valueThis study innovates by examining the causal impact of the initial phase of the PPCDAm before 2008, a period not focused on existing literature. Further, employing the triple difference method innovates methodologically to assess PPCDAm's effect on deforestation in isolated Amazon areas.
Effects of green innovation ecosystem coopetition, environmental management practices and digital innovation on carbon footprint reduction
Authors: Rosa Fabricia S. , Lunkes Rogério João , Codesso Mauricio , Mendes Alcindo Cipriano Argolo , Costa Gabriel Donadio 
Published: November 2024

Purpose
The purpose of this article is to analysis of the effects of green innovation ecosystem coopetition (cooperation and competition), environmental management practices (EMPs) and digital innovation (DI) on carbon footprint reduction.

Design/methodology/approach
To conduct the study, a questionnaire was administered to hotel managers from different regions of Brazil. Data were collected from 197 hotels and analyzed via partial least squares structural equation modeling.

Findings
The results show that green innovation ecosystem cooperation positively and significantly affects EMPs and DI. Green innovation ecosystem competition interactions also benefit the adoption of EMPs. However, they do not significantly influence the use of DI. The results indicate that hotels that are in a scenario of simultaneous competition and collaboration (coopetition) within the green innovation ecosystem can reduce carbon emissions when EMPs and DI are used.

Research limitations/implications
The authors contribute to the literature by showing different pathways for reducing the carbon footprint of hotels. The results expand the authors’ knowledge by showing evidence that cooperation and competition interactions can produce distinct effects, especially on DI. Thus, this study has important practical implications for hotel managers seeking to improve their environmental practices and DI with the help of external multiagent resources and knowledge.

Originality/value
This research contributes to the literature by examining how cooperation and competition interactions in the green innovation ecosystem help in the adoption of environmental management and DI practices.
How to make strategic conversations more AGIL
Authors: Duhamel Francois , Niess Alexander 
Published: November 2024

PurposeThis article addresses the role of communication processes in the formulation and implementation of strategic planning. It seeks to delineate a structured approach to define the contents of strategic conversations among internal stakeholders, to achieve actionable outcomes.Design/methodology/approachThis paper employs a theoretical approach, derived from Talcott Parsons’ AGIL framework, to conceptualize the contents of strategic conversations in a systematic way. Several examples are proposed to illustrate this framework.FindingsConversations among internal stakeholders in organizations, to be deemed strategic, should be orientated towards the formulation and implementation of priorities, procedures, prospective sensemaking and value patterns, as well as the media of interaction connecting them.Originality/valueThis paper offers original insights for practitioners and scholars aiming to comprehend strategic value in communication processes, thanks to Parson’s theoretical views, which have been seldom used in the strategic management literature. Our framework has the originality to offer a more comprehensive and systematic view of the topics making conversations strategic in organizations.
Enhancing pricing strategies in the aftermarket sector with machine learning
Authors: Sarode Mohit S. , Kumar Anil , Prasad Abhijit , Shetty Abhishek 
Published: November 2024

PurposeThis research explores the application of machine learning to optimize pricing strategies in the aftermarket sector, particularly focusing on parts with no assigned values and the detection of outliers. The study emphasizes the need to incorporate technical features to improve pricing accuracy and decision-making.Design/methodology/approachThe methodology involves data collection from web scraping and backend sources, followed by data preprocessing, feature engineering and model selection to capture the technical attributes of parts. A Random Forest Regressor model is chosen and trained to predict prices, achieving a 76.14% accuracy rate.FindingsThe model demonstrates accurate price prediction for parts with no assigned values while remaining within an acceptable price range. Additionally, outliers representing extreme pricing scenarios are successfully identified and predicted within the acceptable range.Originality/valueThis research bridges the gap between industry practice and academic research by demonstrating the effectiveness of machine learning for aftermarket pricing optimization. It offers an approach to address the challenges of pricing parts without assigned values and identifying outliers, potentially leading to increased revenue, sharper pricing tactics and a competitive advantage for aftermarket companies.
Artificial intelligence in management education: transformative potential and challenges
Authors: Cook Jared Scott , Cook Jack 
Published: November 2024

Purpose
The purpose of this paper is to define artificial intelligence (AI) and examine its history, positive and negative impacts, ethical and social implications and implementation within management education. This paper offers various suggestions for the use of AI, as well as context surrounding the current AI landscape.

Design/methodology/approach
The paper uses a narrative review (Sylvester et al., 2013).

Findings
This paper identifies several areas of AI innovation, including AI tutoring systems, feedback systems for student papers, utilization of AI for innovative lesson plans and the use of AI to predict potential student dropout from a course or institution. In addition, there are significant concerns regarding the lack of ethical guidelines with current AI.

Practical implications
Practical implications include the ability to immediately use certain AI tools to enhance lesson plans as well as enhance student work using AI as a tool.

Originality/value
This paper was originally created as a conference presentation and presented at the society for advancement of management (SAM) International Business Conference before being reworked to be submitted to the journal. All content in this paper is original in their creation.
30 years of terrestrial insect richness patterns across elevation: What have we learned? A global meta‐analysis
Authors: Dolson Sarah J. , Kharouba Heather M. 
Published: November 2024

Abstract

Understanding elevation variation in biodiversity is a classic question in ecology and has implications for understanding climate change impacts on mountain ecosystems. While insects are the largest group of animals, the global trend in insect species richness with elevation is unknown. To date, single studies and taxa‐specific syntheses have provided no single picture, finding variable patterns of insect richness with elevation.

A global synthesis across systems would provide a better understanding of how insect species richness changes with elevation and the possible environmental correlates of those patterns. We used published studies of terrestrial insect elevation gradients from 1990 to 2020 to ask: How do insect species richness change with elevation, and which environmental variables best explain this relationship statistically?

With 1486 sites spanning 151 species richness‐elevation gradients from 80 studies from four diverse insect taxonomic groups and five biomes, we found that overall proportional richness reached a low‐elevation plateau and then decreased. We also show that mean annual temperature and seasonality best explain this trend.

We suggest best practices and areas of interest for the future of insect richness‐elevation studies, including underrepresented groups, geographic areas, and more standardized methods.
High‐intensity ultrasound modification of techno‐functional and structural properties of white finger millet protein fractions
Authors: Shylla Eleonora , Sunil C. K. , Rawson Ashish , Venkatachalapathy N. 
Published: November 2024

AbstractIn this study, albumin, globulin, and glutelin were extracted from white finger millet, and their amino acid content, functional and structural properties were investigated. The protein concentration of albumin, globulin, and glutelin were 76.01%, 74.32%, and 69.55%, respectively. The results showed that all the fractions had a significant amount of essential amino acids. Aqueous protein dispersions (10%, w/v) were treated for 12 min at different ultrasound power levels (100, 200, and 300 W). The solubility, emulsifying, and foaming properties of albumin and glutelin were significantly (p < 0.05) improved after ultrasound treatment (20 kHz) which indicates that ultrasound could unfold protein aggregates. A decrease in particle size, increase in surface hydrophobicity, and zeta potential correlated with improved functional properties. Ultrasound treatment reduced the size of all proteins except for fractions at 300 W and also sodium dodecyl sulfate–polyacrylamide gel electrophoresis revealed a significant change in the molecular weight of albumin and glutelin at 300 W. Scanning electron microscopy of treated protein fraction showed distinctive microstructure with irregular structure compared to untreated protein fraction. Although Fourier transform infrared spectroscopy spectra of proteins were similar after ultrasonication, a partial increase in the intensity of the Amide A band was observed. In conclusion, the ultrasound‐treated protein fraction can be used as a high‐value plant‐based emulsifier.
Development, characterization, and comparison of chitosan microparticles as a carrier system for black bean protein hydrolysates with antioxidant capacity
Authors: Alfaro‐Díaz Arturo , Castillo‐Herrera Gustavo A. , Espinosa‐Andrews Hugo , Luna‐Vital Diego , Mojica Luis 
Published: November 2024

AbstractPeptides in black bean protein hydrolysates (BPHs) exert antioxidant capacity. However, peptides are prone to degradation during processing and digestion. Chitosan (Ch) can protect them and provide a delayed release. This work develops and compares two drying methods producing porous structured Ch microparticles (MPs) as carriers for antioxidant BPH. Ch gels were obtained by ionic gelation and dried by supercritical CO2 solvent displacement or fast‐freeze‐drying methods. The resulting aerogels and fast‐freeze‐dried MPs were structurally characterized, and their swelling and release profiles were obtained at pH 1.2 and 7.4. The antioxidant capacity of systems was determined by 2,2′‐azino‐bis(3‐ethyl‐benzthiazoline‐6‐sulphonic acid) (ABTS) and superoxide radical assays. The results showed BPH‐Ch best complexation conditions occurring at a pH of 4.5 and a 4:1 BPH/Ch ratio. The particle size of the complex was 1047.6 nm, and the entrapment efficiency and loading capacity were 28.2% and 54.3%, respectively. At pH 1.2 and 7.4, the release rate of BPH was lower in aerogel than in fast‐freeze‐dried MPs. Besides, entrapment BPH in Ch significantly reduced the ABTS antioxidant activity IC50 from 35.1 µM Trolox equivalents (TE)/mg to 250.7 and 406.2 µM TE/mg for Ch fast‐freeze‐dried and aerogels, respectively. Superoxide radical inhibition IC50 ranged from 74.6 to 92.9 mM ascorbic acid equivalents/mg in the different samples. BPH‐loaded aerogels presented lower specific surface area (94.7 vs. 138.6 m2/g, p < 0.05) and higher average pore size (26.4 vs. 19.8 nm) than Ch aerogels. Ch aerogel is a promising carrier for delaying the release of common bean antioxidant peptides useful for developing functional foods.Practical ApplicationThis novel system could act as an ingredient to incorporate antioxidant compounds in different formats to develop delayed‐release nutraceuticals and functional foods, such as bakery, dairy products, or beverages. Along, antioxidant peptide‐loaded aerogels could be used as a slow‐release system for compounds acting as natural preserving antioxidants for food applications such as raw meat products or high‐fat foods.
Gendered enterprise: Women and Australian business history
Authors: Wright Claire E. F. 
Published: November 2024

AbstractThis special issue examines women and Australian business history. Contributions explore women's entrepreneurship in small urban businesses, side hustles, agriculture, and family companies. Articles highlight the importance of women's businesses, as a financial necessity for women, their families, and their communities. Authors examine the barriers for women in business, including legislation, licensing, societal expectations, and discrimination. Articles also explore women's intersections with other demographic characteristics, with access to enterprise mediated by class and the rural–urban divide. Finally, contributions examine the way traditional archives have obscured histories of businesswomen, and the opportunities offered by feminist historical methodologies for studying business history.
The behavioral dimension of CO2 fertilization effect: Evidence from US harvesting records
Authors: Liu Ziheng 
Published: November 2024

AbstractThe CO2 fertilization effect has been demonstrated to boost crop production by enhancing photosynthesis and reducing drought stress. In addition to this biological channel, there is also a behavioral margin for the CO2 fertilization effect that was previously unnoticed. I find evidence that an additional ppm of average CO2 concentration leads to increases in the corn and soybean harvested ratios of .57 and .75 percentage points, respectively. My predictions suggest that, without considering the adjustment in harvesting decision, the crop production benefits from CO2 fertilization effect would be biasedly estimated for both corn and soybeans, which broadens the understanding of farmers’ behavioral responses to environmental stimuli and extends the knowledge on how CO2 would benefit crop production.
The SQ tree sublingual immunotherapy tablet is effective and well tolerated in children—A pivotal phase III trial
Authors: Gappa Monika , Gagnon Rémi , Horak Fritz , Cichocka‐Jarosz Ewa , Dalgaard Terrie , Hargreaves Kate , Mikler Jan , Emeryk Andrzej , Hansen Kirsten Skamstrup , Pfaar Oliver 
Published: November 2024

AbstractBackgroundAllergic rhinitis and/or conjunctivitis (AR/C) induced by tree pollen is common and negatively impacts quality of life in children and adolescents. This phase III trial investigated the efficacy and safety of the SQ tree SLIT‐tablet in a paediatric population (5–17 years) with moderate‐to‐severe AR/C induced by pollen from birch and trees in the birch homologous group.MethodsNine hundred and fifty‐two subjects were randomized (1:1) to daily treatment with SQ tree SLIT‐tablet or placebo for up to 52 weeks and had free access to AR/C symptom‐relieving medications. The primary endpoint was the average total combined score (TCS); sum of average daily symptom score (DSS) and average daily medication score (DMS) during the birch pollen season (BPS). Key secondary endpoints included average DSS and DMS during BPS and average TCS, DSS and DMS during tree pollen season (TPS).ResultsSQ tree SLIT‐tablet demonstrated a statistically significant and clinically relevant treatment effect compared with placebo for the TCS during BPS with an absolute treatment difference of 1.29 (95% CI: 0.58, 2.00; p = .0004) and a relative reduction of 21.9% (95% CI: 10.6, 31.9). Results were substantiated by reductions in both DSS and DMS versus placebo during the BPS and in DSS, DMS and TCS during the TPS. Treatment was generally well tolerated. Most treatment‐related adverse events were mild or moderate local administration site reactions.ConclusionThis is the first paediatric trial to provide robust evidence of efficacy and safety of the SQ tree SLIT‐tablet in tree pollen‐induced AR/C in a paediatric population (5–17 years).
Early left ventricular unloading during extracorporeal membrane oxygenation in cardiogenic shock: A systematic review and meta‐analysis
Authors: Abuelazm Mohamed , Nawlo Ahmad , Ibrahim Ahmed A. , Amin Ahmed Mazen , Mahmoud Abdelrahman , Elshenawy Salem , Alabdallat Yasmeen Jamal , Turkmani Mustafa , Abdelazeem Basel , Caccamo Marco 
Published: November 2024

AbstractBackgroundLeft ventricular (LV) unloading is a crucial intervention to decrease the harmful consequences of extracorporeal membrane oxygenation (ECMO) on hemodynamic status in cardiogenic shock (CS) patients. However, a lingering question preoccupies experts: Should we intervene early or wait until clinical deterioration caused by increasing afterload is detected?MethodsA systematic review and meta‐analysis synthesizing studies, which were retrieved by systematically searching PubMed, Web of Science, SCOPUS, and Cochrane through December 2023. We used R V. 4.3 to pool dichotomous data using risk ratio (RR) and continuous data using mean difference (MD) with a 95% confidence interval (CI). PROSPERO ID: CRD42024501643.ResultsEight studies with 2.117 patients were included. Early/prophylactic LV unloading was associated with a lower incidence of all‐cause mortality [RR: 0.87 with 95% CI (0.79, 0.95), p < 0.01]. However, there was no significant difference between the two groups regarding cardiac mortality [RR: 1.01 with 95% CI (0.68, 1.48), p = 0.98], non‐cardiac mortality [RR: 0.86 with 95% CI (0.46, 1.62), p = 0.64], and in‐hospital mortality [RR: 0.95 with 95% CI (0.86, 1.05), p = 0.30]. There was no significant difference between the two groups regarding ECMO weaning, myocardial recovery, ECMO duration, and length of hospitalization.ConclusionEarly/prophylactic LV unloading during ECMO for CS patients was associated with a decreased incidence of all‐cause mortality and sepsis or infection, with no effect on ECMO weaning, myocardial recovery, ECMO duration, and hospital length of stay.
A second chance for avatrombopag in chemotherapy‐induced thrombocytopenia
Authors: Al‐Samkari Hanny , Moore Donald C. 
Published: November 2024

Chemotherapy‐induced thrombocytopenia (CIT) remains a common complication of cancer therapy with no approved available treatments in most of the world. Although a prior clinical trial of avatrombopag for CIT did not meet its primary end‐point, a report from Galamaga and colleagues raises prospects for a second chance for avatrombopag in CIT, highlighting the differences between nadir and persistent CIT and the importance of patient selection in CIT treatment.Commentary on: Galamaga et al. Avatrombopag for the treatment of patients with chemotherapy‐induced thrombocytopenia: a case series. Br J Haematol 2025; 206:272‐278.