bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term Patient-reported Quality of Life and Pain After a Multidisciplinary Clinical Pathway for Elderly Patients With Hip Fracture: A Retrospective Comparative Cohort Study
Authors: Kalmet Pishtiwan H. S. , de Joode Stijn G. C. J. , Fiddelers Audrey A. A. , ten Broeke Rene H. M. , Poeze Martijn , Blokhuis Taco 
Published: June 2019

Introduction: There is an increase in incidence of hip fractures in the ageing population. The implementation of multidisciplinary clinical pathways (MCP) has proven to be effective in improving the care for these frail patients, and MCP tends to be more effective than usual care (UC). The aim of this study was to analyze potential differences in patient-reported outcome among elderly patients with hip fractures who followed MCP versus those who followed UC. Materials and Methods: This retrospective cohort study included patients aged 65 years or older with a low-energy hip fracture, who underwent surgery in the Maastricht University Medical Center, Maastricht, the Netherlands. Two cohorts were analyzed; the first one had patients who underwent UC in 2012 and the second one contained patients who followed MCP in 2015. Collected data regarded demographics, patient-reported outcomes (Short Form 12 [SF-12] and the Numeric Rating Scale [NRS] to measure pain), and patient outcome. Results: This cohort study included 398 patients, 182 of them were included in the MCP group and 216 were in the UC group. No differences in gender, age, or American Society of Anesthesiologists classification were found between the groups. No significant differences were found in SF-12 and the NRS data between the MCP group and UC group. In the MCP group, significantly lower rates of postoperative complications were found than in the UC group, but mortality within 30 days and one year after the hip fracture was similar in both groups. Discussion: Although the effects of hip fractures in the elderly on patient-reported outcome, pain and quality of life have been addressed in several recent studies, the effects of MCP on long-term outcome was unclear. Conclusion: A multidisciplinary clinical pathway approach for elderly patients with a hip fracture is associated with a reduced time to surgery and reduced postoperative complications, while no differences were found in quality of life, pain, or mortality.
Successful treatment of late onset post-phacoemulsification Descemet’s membrane detachment
Authors: Kocak Altintas Ayse Gul , Ilhan Cagri 
Published: June 2019

Purpose: To present a case with the late-onset post-phacoemulsification Descemet’s membrane detachment that has been treated successfully. Methods: Case report. Results: A 68-year-old female patient presented with the complaint of decreased vision in her pseudophakic left eye after a 4-week silent post-phacoemulsification period. In the biomicroscopy, corneal oedema was seen to be prominent on the nasal incision side. Anterior segment optical coherence tomography objectively revealed the presence of Descemet’s membrane detachment. Treatment of descemetopexy was applied by injecting 0.3-mL perfluoropropane gas into the anterior chamber. No complication associated with descemetopexy was noticed during recovery. Total Descemet’s membrane detachment reattachment was achieved and perfluoropropane gas resorption from the anterior chamber was completed by the end of 1-month post-injection. The cornea was transparent and best corrected visual acuity increased to 20/20. Discussion: DMD is a rare complication following phacoemulsification and this patient had not any preoperative, intraoperative, or postoperative risk factors for DMD.It generally occurs in early-postoperative period and late-onset DMDs have been reported less frequently.The success rates with intracameral gas injections in similar cases have been reported to be 90% - 95%. Conclusion: To the best of our knowledge, this is one of the latest onset post-phacoemulsification Descemet’s membrane detachment cases in literature that has been treated successfully. The results of this case showed that descemetopexy is a safe and effective treatment method for late-onset post-phacoemulsification DMD.
Efficacy of Mentalization-based group therapy for adolescents: the results of a pilot randomised controlled trial
Authors: Griffiths Helen , Duffy Fiona , Duffy Louise , Brown Sarah , Hockaday Harriet , Eliasson Emma , Graham Jessica , Smith Julie , Thomson Alice , Schwannauer Matthias 
Published: June 2019

Abstract
Background
Mentalization Based Therapy (MBT) has yielded promising outcomes for reducing self-harm, although to date only one study has reported MBT’s effectiveness for adolescents (Rossouw and Fonagy, J Am Acad Child Adolesc Psychiatry 51:1304–1313, 2012) wherein the treatment protocol consisted of an intensive programme of individual and family therapy. We sought to investigate an adaptation of the adult MBT introductory manual in a group format for adolescents.

Methods
The present study is a randomised controlled single blind feasibility trial that aims to (1) adapt the original explicit MBT introductory group manual for an adolescent population (MBT-Ai) and to (2) assess the feasibility of a trial of MBT-Ai through examination of consent rates, attendance, attrition and self-harm. Repeated measures ANOVAs were conducted to examine change over time in independent and dependent variables between groups, and multi level models (MLM) were conducted to examine key predictors in relation to change over time with self-report self-harm and emergency department presentation for harm as the primary outcome variables.

Results
Fifty-three young people consented to participate and were randomised to MBT-Ai + TAU or TAU alone. Five participants withdrew from the trial. Trial procedures seemed appropriate and safe, with acceptable group attendance. Self-reported self-harm and emergency department presentation for self-harm significantly decreased over time in both groups, though there were no between group differences. Social anxiety, emotion regulation, and borderline traits also significantly decreased over time in both groups. Mentalization emerged as a significant predictor of change over time in self reported self harm and hospital presentation for self-harm.

Conclusions
It was feasible to carry out an RCT of MBT-Ai for adolescents already attending NHS CAMHS who have recently self-harmed. Our data gave signals that suggested a relatively brief group-based MBT-Ai intervention may be a promising intervention with potential for service implementation. Future research should consider the appropriate format, dosage and intensity of MBT for the adolescent population.

Trial registration
NCT02771691; Trial Registration Date: 25/04/2016.
RETRACTED ARTICLE: Overexpression of microRNA-195-5p reduces cisplatin resistance and angiogenesis in ovarian cancer by inhibiting the PSAT1-dependent GSK3β/β-catenin signaling pathway
Authors: Dai Jun , Wei Rujia , Zhang Peihai , Kong Beihua 
Published: June 2019

Abstract
Background
Ovarian cancer (OC) is one of the leading causes for cancer-related deaths among women. MicroRNAs (miRs) have been proved to be vital to the development and progression of OC. Hence, the study aims to evaluate the ability of miR-195-5p affecting cisplatin (DDP) resistance and angiogenesis in OC and the underlying mechanism.

Methods
MiRs that could target phosphoserine aminotransferase 1 (PSAT1), a differentially expressed gene in OC, were predicted by miRNA-mRNA prediction websites. The expression patterns of miR-195-5p in the OC tissues and cells were determined using RNA quantification assay. The role of miR-195-5p in OC was evaluated by determining DDP resistance, apoptosis and angiogenesis of OC cells after up-regulating or down-regulating miR-195-5p or PSAT1, or blocking the glycogen synthase kinase-3β (GSK3β)/β-catenin signaling pathway. Animal experiment was conducted to explore the effect of miR-195-5p on resistance to DDP and angiogenesis.

Result
MiR-195-5p directly targeted PSAT1 and down-regulated its expression. The expression of miR-195-5p was lower while that of PSAT1 was higher in OC tissues than in adjacent normal tissues. When miR-195-5p was over-expressed or PSAT1 was silenced, the expression of HIF-1α, VEGF, PSAT1, β-catenin as well as the extent of GSK3β phosphorylation was reduced, the angiogenesis and resistance to DDP was diminished and apoptosis was promoted both in vitro and in vivo. The inhibition of GSK3β/β-catenin signaling pathway was involved in the regulation process.

Conclusion
Over-expression of miR-195-5p reduced angiogenesis and DDP resistance in OC, which provides a potential therapeutic target for the treatment of OC.
Tenofovir-associated kidney disease in Africans: a systematic review
Authors: Mtisi Takudzwa J. , Ndhlovu Chiratidzo E. , Maponga Chiedza C. , Morse Gene D. 
Published: June 2019

Abstract
Background
Data on chronic kidney disease development in HIV infection is important towards building a comprehensive knowledge of HIV, ageing and polypharmacy in Africa. Several previous studies on tenofovir-associated kidney disease in Africa have shown conflicting results. This review summarises what is known about the development of kidney disease in HIV-positive African patients on tenofovir disoproxil fumarate (TDF)-containing ART. We set out to document the occurrence of kidney disease in HIV-positive Africans on TDF-containing ART in population-based studies and to evaluate the renal safety of TDF in Africans.

Methods
We conducted a systemic review using published studies which were identified through a computerized search of original research using the Medline/PubMed database, EMBASE, EBM Reviews, Proquest Google Scholar and Global Health reported from inception until 5 October 2017. Two reviewers independently abstracted the data and performed quality assessment of the included studies. We screened 595 articles and included 31 in the qualitative analysis performed.

Results
A total of 106 406 patients (of whom 66,681 were on Tenofovir) were involved in these 31 studies with sample sizes ranging from 30 to 62,230. Duration on tenofovir-containing ART ranged from those initiating ART at baseline to those who received TDF for up to 9 years. All but one of the studies involved only patients 16 years and older. The studies had differing definitions of kidney dysfunction and were of variable study design quality. The documented outcomes had substantial discrepancies across the studies, most likely due to methodological differences, study size and disparate outcome definitions.

Conclusions
Our review identified studies in Africans reporting statistically significant renal function decline associated with TDF use but the clinical significance of this effect was not enough to contraindicate its continued use in ART regimens. Consistent with studies in other populations, patients are at greater risk if they have pre-existing renal disease and are more advanced in age. More research is needed on paediatric populations under 16 years of age.
Trial registration This review was registered on Prospero (registration number CRD42018078717).
Is Colorectal Cancer Screening Appropriate in Nigeria?
Authors: Knapp Gregory C. , Alatise Olusegun I. , Olasehinde Olalekan O. , Adeyeye Ademola , Ayandipo Omobolaji O. , Weiser Martin R. , Kingham T. Peter 
Published: June 2019

PURPOSE The global burden of colorectal cancer (CRC) will continue to increase for the foreseeable future, largely driven by increasing incidence and mortality in low- and middle-income countries (LMICs) such as Nigeria. METHODS We used the Wilson-Jungner framework (1968) to review the literature relevant to CRC screening in Nigeria and propose areas for future research and investment. RESULTS Screening is effective when the condition sought is both important and treatable within the system under evaluation. The incidence of CRC is likely increasing, although the exact burden of disease in Nigeria remains poorly understood and access to definitive diagnosis and treatment has not been systematically quantified. In high-income countries (HICs), CRC screening builds on a well-known natural history. In Nigeria, a higher proportion of CRC seems to demonstrate microsatellite instability, which is dissimilar to the molecular profile in HICs. Prospective trials, tissue banking, and next-generation sequencing should be leveraged to better understand these potential differences and the implications for screening. Fecal immunochemical test for hemoglobin (FIT) is recommended for LMICs that are considering CRC screening. However, FIT has not been validated in Nigeria, and questions about the impact of high ambient temperature, endemic parasitic infection, and feasibility remain unanswered. Prospective trials are needed to validate the efficacy of stool-based screening, and these trials should consider concomitant ova and parasite testing. CONCLUSION Using the Wilson-Jungner framework, additional work is needed before organized CRC screening will be effective in Nigeria. These deficits can be addressed without missing the window to mitigate the increasing burden of CRC in the medium to long term.
Evidence of dietary protein restriction regulating pupation height, development time and lifespan in Drosophila melanogaster
Authors: Krittika Sudhakar , Lenka Alisha , Yadav Pankaj 
Published: June 2019

ABSTRACT
Fitness and behavioral traits are optimized according to the rearing environment to ensure survival of most organisms including fruit flies Drosophila melanogaster. Fruit flies are known to uphold various trade-offs in their lifespan, development time, fecundity, etc., to confer better survival in the particular exposed environment. The diet of D. melanogaster plays a major role between larval and adult fitness or fitness related traits; its role in the regulation of correlations between pupation height, pre-adult development and adult fitness has not been studied empirically. In our study, we assayed the effect of restricting dietary protein alone from the larval stage to adult stage in fruit flies and studied development time, pre-adult survivorship, pupation height, larval feeding rate and their corresponding lifespan under a light/dark cycle (LD12:12 h). We found that under very low protein concentration in diet, development time and lifespan of the flies increased significantly, along with decreased pupation height and vice versa, while pre-adult survivorship remained unchanged across diets. The results from our study can be taken to suggest that development time is negatively and positively correlated with pupation height and adult lifespan respectively. Thus, a higher protein restriction decreases pupation height and increases development time and vice versa, thereby emphasizing differential alterations taken up by various fitness traits, probably to enhance the overall organismal fitness.
This article has an associated First Person interview with the first author of the paper.
Cellular stress due to impairment of collagen prolyl hydroxylation complex is rescued by the chaperone 4-phenylbutyrate
Authors: Besio Roberta , Garibaldi Nadia , Leoni Laura , Cipolla Lina , Sabbioneda Simone , Biggiogera Marco , Mottes Monica , Aglan Mona , Otaify Ghada A. , Temtamy Samia A. , Rossi Antonio , Forlino Antonella 
Published: June 2019

ABSTRACT
Osteogenesis imperfecta (OI) types VII, VIII and IX, caused by recessive mutations in cartilage-associated protein (CRTAP), prolyl-3-hydroxylase 1 (P3H1) and cyclophilin B (PPIB), respectively, are characterized by the synthesis of overmodified collagen. The genes encode for the components of the endoplasmic reticulum (ER) complex responsible for the 3-hydroxylation of specific proline residues in type I collagen. Our study dissects the effects of mutations in the proteins of the complex on cellular homeostasis, using primary fibroblasts from seven recessive OI patients. In all cell lines, the intracellular retention of overmodified type I collagen molecules causes ER enlargement associated with the presence of protein aggregates, activation of the PERK branch of the unfolded protein response and apoptotic death. The administration of 4-phenylbutyrate (4-PBA) alleviates cellular stress by restoring ER cisternae size, and normalizing the phosphorylated PERK (p-PERK):PERK ratio and the expression of apoptotic marker. The drug also has a stimulatory effect on autophagy. We proved that the rescue of cellular homeostasis following 4-PBA treatment is associated with its chaperone activity, since it increases protein secretion, restoring ER proteostasis and reducing PERK activation and cell survival also in the presence of pharmacological inhibition of autophagy. Our results provide a novel insight into the mechanism of 4-PBA action and demonstrate that intracellular stress in recessive OI can be alleviated by 4-PBA therapy, similarly to what we recently reported for dominant OI, thus allowing a common target for OI forms characterized by overmodified collagen.
This article has an associated First Person interview with the first author of the paper.
Age-associated Performance Decline and Sex Differences in Olympic Weightlifting
Authors: HUEBNER MARIANNE , MELTZER DAVID E. , PERPEROGLOU ARIS 
Published: June 2019

ABSTRACT

Introduction
The rate of decline in physical performance for women is thought to be faster than that for men at any age in the Masters age classes in weightlifting and other sports. We quantified the age-associated decline in Olympic weightlifting separately for women and men and investigated possible impact of perimenopausal years on the performance decline.

Methods
Results from Masters Weightlifting competitions from 1993 to 2018 were compiled from original score sheets and meet results made available by International Weightlifting Federation. Quantile curves were estimated for the age-related performance decline, and confidence intervals (CI) for the fractional performance with reference age 35 yr were calculated. Age-related decline curves were estimated for different periods to examine changes in performance levels.

Results
A total of 10,225 performance results for male and female weightlifters age 35 to 90 yr from 71 countries were included in the analysis. At age 40 yr compared with age 35 yr, the fractional performance is 0.947 (95% CI, 0.926–0.975), for men and 0.952 (95% CI. 0.898–0.986) for women while this is reduced to 0.723 (95% CI: 0.651–0.800) at age 60 yr for men and 0.604 (95% CI. 0.543–0.706) for women. Female performance levels before 2000 were worse; however, they have stabilized since 2013.

Conclusions
The performances of women weightlifters have improved over the last 25 yr. Thus, previous publications do not reflect current physical capabilities of women. The age-associated performance decline for female weightlifters mirrors the decline for men except for an accelerated decline during a 10-yr period across the age range from late 40s to late 50s thus coinciding with a transition into menopause.
When a patient complains
Authors: Croser David 
Published: June 2019

In the first of a two-part CPD paper, David Croser considers why patients complain and how the dental team should respond Aim Part 2 will be published in the next issue of Dental Nursing. It provides a checklist to help deal with patient complaints in-house. When read together, these two articles will: Update an understanding of a CPD topic recommended by the General Dental Council Objectives To describe communication skills that support best practice complaints management To understand the risk management strategies behind the steps involved in handling a complaint To understand the benefits of an informal in-house practice complaints procedure so patients can raise issues at an early opportunity This article relates to GDC development outcomes A and D
European Biological Variation Study (EuBIVAS): Within- and Between-Subject Biological Variation Data for 15 Frequently Measured Proteins
Authors: Carobene Anna , Aarsand Aasne K , Guerra Elena , Bartlett William A , Coşkun Abdurrahman , Díaz-Garzón Jorge , Fernandez-Calle Pilar , Jonker Niels , Locatelli Massimo , Sandberg Sverre , Ceriotti Ferruccio 
Published: June 2019

Abstract

BACKGROUND
The European Biological Variation Study (EuBIVAS) was established to deliver rigorously determined data for biological variation (BV). Here, EuBIVAS-based BV estimates are provided for α1-acid glycoprotein, α1-antitrypsin, albumin, β2-microglobulin, ceruloplasmin, complement component 3, complement component 4, C-reactive protein (CRP), cystatin C, haptoglobin, IgA, IgG, IgM, soluble transferrin receptor (sTfR), and transferrin (Trf), together with their associated analytical performance specifications (APSs) and reference change values (RCVs).

METHOD
Serum samples from weekly blood samplings of 91 healthy study participants (38 males and 53 females, ages 21–69 years old) over 10 consecutive weeks in 6 European laboratories were stored at −80 °C before duplicate analysis on a Roche Cobas c702. Outlier and variance homogeneity analyses were performed followed by CV-ANOVA on trend-corrected data if relevant, to determine BV and analytical variation estimates with CI and the associated RCV.

RESULTS
For the acute phase proteins, several participants experienced mild inflammatory episodes during the study, requiring exclusion of 7% of the 25290 results. Within-subject BV (CVI) estimates for specific proteins obtained in our study were lower than those available in the online 2014 BV database, except for Trf, whereas between-subject BV (CVG) estimates were similar. CVI and CVG estimates for sTfR, which have not previously been published, were 6.0% and 19.1%, respectively.

CONCLUSIONS
In addition to new BV estimates for sTfR, this EuBIVAS substudy generated more demanding APS for frequently requested plasma specific proteins. APS for CRP should not be calculated from BV data except when CRP is used as a risk factor for cardiovascular disease.
GOBERNABILIDAD, SISTEMA PARLAMENTARIO Y FÓRMULA ELECTORAL LA CRISIS DEL SISTEMA CONSTITUCIONAL ESPAÑOL
Authors: Miguel Carlos Ruiz 
Published: June 2019

La gobernabilidad es el objetivo de todo sistema político y en ocasiones el sistema parlamentario es criticado por obstaculizarla. La fórmula electoral constituye el elemento esencial que explica algunas disfunciones en la gobernabilidad de ciertos sistemas parlamentarios. El caso de España es una buena ilustración de ello.