bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermal induced shape‐memory and self‐healing of segmented polyurethane containing diselenide bonds
Authors: Du Weining , Jin Yong , Pan Jiezhou , Fan Wuhou , Lai Shuangquan , Sun Xiaopeng 
Published: February 2018

ABSTRACTHerein, we synthesized a series of polyurethane copolymers (PUs) with poly(1,4‐butylene adipate) glycol as soft segment and 2,4‐toluene diisocyanate as well as extenders including 1,4‐butanediol and di(1‐hydroxyethylene) diselenide as hard segment. The chemical structure, thermal property, crystallization behavior, shape memory, and self‐healing performances of the PUs were systematically characterized by a series of experiments. It was found that the PU2 containing a higher diselenide component (∼33 mol %) exhibited both shape memory and self‐healing behaviors under a moderate temperature (∼57 °C). Meanwhile, the PUs showed a good repeatability of shape memory function, and their fixity and recovery ratios were all above 90%. Additionally, the dynamic exchangeable feature of diselenide bonding endues the PUs chains with an acceptable reprocessability and self‐healing performances, and the PU2 sample could be healed for five times by thermal treatment with the healing efficiencies above 70%. This work provides a heuristic perspective for the development of shape memory and self‐healing materials. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46326.
Switching From Reference Adalimumab to SB5 (Adalimumab Biosimilar) in Patients With Rheumatoid Arthritis
Authors: Weinblatt Michael E. , Baranauskaite Asta , Dokoupilova Eva , Zielinska Agnieszka , Jaworski Janusz , Racewicz Artur , Pileckyte Margarita , Jedrychowicz‐Rosiak Krystyna , Baek Inyoung , Ghil Jeehoon 
Published: February 2018

ObjectiveThe 24‐week equivalent efficacy and comparable safety results of the biosimilar SB5 and reference adalimumab (ADA) from the phase III randomized study in patients with moderate‐to‐severe rheumatoid arthritis (RA) have been reported previously. We undertook this transition study to evaluate patients who switched from ADA to SB5 or who continued to receive SB5 or ADA up to 52 weeks.MethodsIn this phase III study, patients were initially randomized 1:1 to receive SB5 or ADA (40 mg subcutaneously every other week). At 24 weeks, patients receiving ADA were rerandomized 1:1 to continue with ADA (ADA/ADA group) or to switch to SB5 (ADA/SB5 group) up to week 52; patients receiving SB5 continued with SB5 for 52 weeks (SB5 group). Efficacy, safety, and immunogenicity were evaluated up to 52 weeks.ResultsThe full analysis set population consisted of 542 patients (269 in the SB5 group, 273 in the ADA overall group [patients who were randomized to receive ADA at week 0], 125 in the ADA/SB5 group, and 129 in the ADA/ADA group). The percentages of patients meeting the American College of Rheumatology 20%, 50%, or 70% improvement criteria (achieving an ACR20, ACR50, or ACR70 response) at week 24 were maintained after the transition from ADA to SB5, and these response rates were comparable across treatment groups throughout the study. ACR20 response rates ranged from 73.4% to 78.8% at week 52. Radiographic progression was minimal and comparable across treatment groups. The safety profile and the incidence of antidrug antibodies were comparable across treatment groups after transition.ConclusionSB5 was well tolerated over 1 year in patients with RA, with efficacy, safety, and immunogenicity comparable to those of ADA. Switching from ADA to SB5 had no treatment‐emergent issues such as increased adverse events, increased immunogenicity, or loss of efficacy.
Augmented Th17 Differentiation Leads to Cutaneous and Synovio‐Entheseal Inflammation in a Novel Model of Psoriatic Arthritis
Authors: Yang Lu , Fanok Melania H. , Mediero‐Munoz Aranzazu , Fogli Laura K. , Corciulo Carmen , Abdollahi Shahla , Cronstein Bruce N. , Scher Jose U. , Koralov Sergei B. 
Published: February 2018

ObjectiveTo introduce a novel preclinical animal model of psoriatic arthritis (PsA) in R26Stat3Cstopfl/fl CD4Cre mice, and to investigate the role of Th17 cytokines in the disease pathogenesis.MethodsWe characterized a novel murine model of Th17‐driven cutaneous and synovio‐entheseal disease directed by T cell–specific expression of a hyperactive Stat3 allele. By crossing R26Stat3Cstopfl/fl CD4Cre mice onto an interleukin‐22 (IL‐22)–knockout background or treating the mice with a neutralizing antibody against IL‐17, we interrogated how these Th17 cytokines could contribute to the pathogenesis of PsA.ResultsR26Stat3Cstopfl/fl CD4Cre mice developed acanthosis, hyperkeratosis, and parakeratosis of the skin, as well as enthesitis/tendinitis and periarticular bone erosion in different joints, accompanied by osteopenia. T cell–specific expression of a hyperactive Stat3C allele was found to drive the augmented Th17 response in these animals. Careful characterization of the mouse bone marrow revealed an increase in osteoclast progenitor (OCP) and RANKL‐producing cells, which contributed to the osteopenia phenotype observed in the mutant animals. Abrogation of the Th17 cytokines IL‐17 or IL‐22 improved both the skin and bone phenotype in R26Stat3Cstopfl/fl CD4Cre mice, revealing a central role of Th17 cells in the regulation of OCP and RANKL expression on stromal cells.ConclusionPerturbation of the IL‐23/Th17 axis instigates Th17‐mediated inflammation in R26Stat3Cstopfl/fl CD4Cre mice, leading to cutaneous and synovio‐entheseal inflammation and bone pathologic features highly reminiscent of human PsA. Both IL‐17A and IL‐22 produced by Th17 cells appear to play critical roles in promoting the cutaneous and musculoskeletal inflammation that characterizes PsA.
Copper‐Catalyzed Asymmetric Synthesis of Borylated cis‐Disubstituted Indolines
Authors: Li DingXi , Kim Jiwon , Yang Jung Woon , Yun Jaesook 
Published: February 2018

AbstractA copper‐catalyzed, intramolecular borylative cyclization of vinyl arenes with imines is reported, which affords enantio‐enriched indolines as a single diastereomer under mild conditions. A benzylcopper species is generated by Cu‐Bpin addition to the alkene, which then acts as a nucleophile for intramolecular imine addition. The reaction is applicable to various vinyl arenes with an imine moiety at the ortho‐position, including heterocycles, for formation of borylated indolines in good yields and ee values up to 90 %.
Proneness to guilt, shame, and pride in children with Autism Spectrum Disorders and neurotypical children
Authors: Davidson Denise , Hilvert Elizabeth , Misiunaite Ieva , Giordano Michael 
Published: February 2018

Self‐conscious emotions (e.g., guilt, shame, and pride) are complex emotions that require self‐reflection and self‐evaluation, and are thought to facilitate the maintenance of societal norms and personal standards. Despite the importance of self‐conscious emotions, most research has focused on basic emotion processing in children with Autism Spectrum Disorders (ASD). Therefore, in the present study, we used the Test of Self‐Conscious Affect for Children (TOSCA‐C) to assess proneness to, or propensity to experience, the self‐conscious emotions guilt, shame, and pride in children with ASD and neurotypical children. The TOSCA‐C is designed to capture a child's natural tendency to experience a given emotion across a range of everyday situations [Tangney, Stuewig, & Mashek, 2007]. We also assessed how individual characteristics contribute to the development of proneness to self‐conscious emotions, including theory of mind (ToM) and ASD symptomatology. In comparison to neurotypical children, children with ASD showed less proneness to guilt, although all children showed relatively high levels of proneness to guilt. Greater ToM ability was related to more proneness to guilt and authentic pride in children with ASD. Additionally, we found that children with ASD with more severe symptomatology were more prone to hubristic pride. Our results provide evidence of differences in proneness to self‐conscious emotions in children with ASD, as well as highlight important mechanisms contributing to how children with ASD may experience self‐conscious emotions. Autism Res 2018,11:883–892. ©2017 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryThis research examined proneness to guilt, shame, and pride in children with Autism Spectrum Disorders (ASD) and neurotypical children. We found that children with ASD showed less proneness to guilt than neurotypical children. Better understanding of theory of mind was related to greater proneness to guilt and pride, but only for children with ASD. These findings are important because these complex emotions are linked with both positive and negative social behaviors towards others and oneself.
Ein innovatives Betonschalenbauverfahren in Anwendung: Herstellung der Wildbrücke AM2 mit PFHC
Authors: Kromoser Benjamin , Kollegger Johann , Kari Hannes , Gradenegger Karin , Ganster Martin 
Published: February 2018

AbstractFertiggestellte Betonschalen sind bei Auswahl einer geeigneten Geometrie ästhetische und wirtschaftliche Tragwerke, die mit einem Minimum an Material hohe Lasten abtragen und große Flächen überspannen können. Der hohe Aufwand für die Schalung führt zu hohen Kosten, die die Errichtung meist unwirtschaftlich machen. Am Institut für Tragkonstruktionen der TU Wien wurde in den vergangenen Jahren ein neues Betonschalenbauverfahren mit dem Namen Pneumatic Forming of Hardened Concrete (PFHC) entwickelt. Nach Durchlaufen eines straffen Entwicklungsprozesses, der zahlreiche Materialversuche, Zugversuche, Biegeversuche und auch Großversuche umfasste, wurde das Bauverfahren nun erstmals praktisch von den Österreichischen Bundesbahnen (ÖBB) im großen Maßstab für die Errichtung der Wildbrücke AM2 angewendet. Zuerst wurde eine Probeschale mit den Grundrissabmessungen 26,5 m × 19,1 m und einer Höhe von 4,2 m, die nun als Veranstaltungsüberdachung genutzt wird, gebaut. Anschließend wurde das Tragwerk der Brücke (Grundrissabmessungen 36,2 m × 38,7 m, Höhe 8,1 m) errichtet. Der erste, bereits in der vorigen Ausgabe veröffentlichte Teil des Beitrags fasst den Entwicklungsprozess zusammen und beschreibt den Einsatz digitaler Planungs‐ und Fertigungsmethoden für die Umsetzung des Projekts. Im zweiten Teil des Aufsatzes werden nun der gewählte Bauablauf, durchgeführte Versuche, ausgewählte Ausführungsdetails sowie das gewählte Messkonzept beschrieben.
The effect of a competitive strategy and green supply chain management on the financial and environmental performance of logistics service providers
Authors: Laari Sini , Töyli Juuso , Ojala Lauri 
Published: February 2018

AbstractDespite the critical role of logistics service providers (LSPs) in improving the environmental sustainability of supply chains, there is still uncertainty about how LSPs can turn environmental management into competitive advantage. Based on a Finnish national logistics survey and financial reporting data from 266 LSPs, this article examines their competitive strategies and green supply chain management (GSCM), and tests their respective relationships with environmental and financial performance. Financial data are used to measure financial performance in a novel way. The findings indicate that leading LSPs with operational excellence and strong brands are more advanced in terms of GSCM than LSPs that do not excel in any competitive priority. GSCM practices are positively related to environmental performance, but not to financial performance. However, managers should not be discouraged by the apparent absence of short‐term financial benefits of GSCM practices, which in any case could enhance future differentiation opportunities.
Phase 1–3 of the cross‐cultural development of an EORTC questionnaire for the assessment of sexual health in cancer patients: the EORTC SHQ‐22
Authors: Oberguggenberger Anne Sophie , Nagele Eva , Inwald Elisabeth C. , Tomaszewski Krzysztof , Lanceley Anne , Nordin Andy , Creutzberg Carien L. , Kuljanic Karin , Kardamakis Dimitrios , Schmalz Claudia , Arraras Juan , Costantini Anna , Almont Thierry , Wei‐Chu Chie , Dehandschutter Sara , Winters Zoe , Greimel Elfriede ,   the EORTC Quality of Life Group
Published: February 2018

AbstractTo develop and pretest an European Organization for the Research and Treatment of Cancer Sexual Health Questionnaire (EORTC SHQ‐22) for the assessment of physical, psychological, and social aspects of sexual health (SH) in male and female cancer patients and survivors. Questionnaire construction started with creating a list of relevant SH issues based on a comprehensive literature review. Issues were subsequently evaluated for relevance and prioritization by 78 healthcare professionals (HCP) and 107 patients from 12 countries during in‐depth interviews (phase 1). Extracted issues were operationalized into items (phase 2). Phase 3 focused on pretesting the preliminary questionnaire in a cross‐cultural patient sample (n = 171) using debriefing interviews. Psychometric properties were preliminary determined using a principal component analysis and Cronbach's alpha. We derived 53 relevant SH issues from the literature. Based on HCP and patient interviews, 22 of these 53 issues were selected and operationalized into items. Testing the preliminary 22‐item short questionnaire resulted in a change of wording in five items and two communication‐related items; no items were removed. Preliminary psychometric analysis revealed a two‐factor solution and 11 single items; both scales showed good reliability indicated by a Cronbach's alpha of 0.87 (sexual satisfaction) and 0.82 (sexual pain). Cross‐cultural pretesting of the preliminary EORTC SH questionnaire has indicated excellent applicability, patient acceptance, and comprehensiveness as well as good psychometric properties. The final development phase, that is psychometric validation (phase four) including large‐scale, cross‐cultural field testing of the EORTC SHQ‐22, has commenced.
Microsatellite instability status determined by next‐generation sequencing and compared with PD‐L1 and tumor mutational burden in 11,348 patients
Authors: Vanderwalde Ari , Spetzler David , Xiao Nianqing , Gatalica Zoran , Marshall John 
Published: February 2018

AbstractMicrosatellite instability (MSI) testing identifies patients who may benefit from immune checkpoint inhibitors. We developed an MSI assay that uses data from a commercially available next‐generation sequencing (NGS) panel to determine MSI status. The assay is applicable across cancer types and does not require matched samples from normal tissue. Here, we describe the MSI‐NGS method and explore the relationship of MSI with tumor mutational burden (TMB) and PD‐L1. MSI examined by PCR fragment analysis and NGS was compared for 2189 matched cases. Mismatch repair status by immunohistochemistry was compared to MSI‐NGS for 1986 matched cases. TMB was examined by NGS, and PD‐L1 was determined by immunohistochemistry. Among 2189 matched cases that spanned 26 cancer types, MSI‐NGS, as compared to MSI by PCR fragment analysis, had sensitivity of 95.8% (95% confidence interval [CI] 92.24, 98.08), specificity of 99.4% (95% CI 98.94, 99.69), positive predictive value of 94.5% (95% CI 90.62, 97.14), and negative predictive value of 99.2% (95% CI, 98.75, 99.57). High MSI (MSI‐H) status was identified in 23 of 26 cancer types. Among 11,348 cases examined (including the 2189 matched cases), the overall rates of MSI‐H, TMB‐high, and PD‐L1 positivity were 3.0%, 7.7%, and 25.4%, respectively. Thirty percent of MSI‐H cases were TMB‐low, and only 26% of MSI‐H cases were PD‐L1 positive. The overlap between TMB, MSI, and PD‐L1 differed among cancer types. Only 0.6% of the cases were positive for all three markers. MSI‐H status can be determined by NGS across cancer types. MSI‐H offers distinct data for treatment decisions regarding immune checkpoint inhibitors, in addition to the data available from TMB and PD‐L1.
A Neutral RuII Hydride Complex for the Regio‐ and Chemoselective Reduction of N‐Silylpyridinium Ions
Authors: Bähr Susanne , Oestreich Martin 
Published: February 2018

AbstractA detailed experimental analysis of the 1,4‐selective reduction of pyridine with hydrosilanes catalyzed by a coordinatively unsaturated RuII thiolate complex is reported. The previously suggested intermediates, N‐silylpyridinium ions and a neutral RuII hydride, have been independently synthesized and do indeed participate in the catalytic cycle. The resting state is not the cationic RuII complex initially used as the catalyst but its pyridine‐coordinated congener. All RuII complexes, including the one resulting from hydrosilane activation, are in equilibrium with each other. The N‐silylated 1,4‐dihydropyridine together with the cationic RuII complex convert back into the corresponding N‐silylpyridinium ion and the neutral RuII hydride (retro‐hydrosilylation), followed by further backward reaction into the hydrosilane and the pyridine adduct of the cationic complex. These steps prove the overall reversibility of the transformation.
Aerobic Oxidation Catalysis by a Molecular Barium Vanadium Oxide
Authors: Lechner Manuel , Kastner Katharina , Chan Chee Jian , Güttel Robert , Streb Carsten 
Published: February 2018

AbstractAerobic catalytic oxidations are promising routes to replace environmentally harmful oxidants with O2 in organic syntheses. Here, we report a molecular barium vanadium oxide, [Ba4(dmso)14V14O38(NO3)] (={Ba4V14}) as viable homogeneous catalyst for a series of oxidation reactions in N,N‐dimethyl formamide solution under oxygen (8 bar). Starting from the model compound 9,10‐dihydroanthracene, we report initial dehydrogenation/ aromatization leading to anthracene formation; this intermediate is subsequently oxidized by stepwise oxygen transfer, first giving the mono‐oxygenated anthrone and then the di‐oxygenated target product, anthraquinone. Comparative reaction analyses using the Neumann catalyst [PV2Mo10O40]5− as reference show that oxygen diffusion into the reaction mixture is the rate‐limiting step, resulting in accumulation of the reduced catalyst species. This allows us to propose improved reactor designs to overcome this fundamental challenge for aerobic oxidation catalysis.
A Multifunctional Pincer Ligand for Cobalt‐Promoted Oxidation by N2O
Authors: Cook Brian J. , Chen Chun‐Hsing , Caulton Kenneth G. 
Published: February 2018

AbstractThe divalent cobalt complex of the diprotic pincer ligand bis‐pyrazolylpyridine, (H2L)CoCl2, is dehydrohalogenated twice by LiN(SiMe3)2 in the presence of PEt3 to give monomeric S=1/2 LCo(PEt3)2 (1), fully characterized in the solid‐state and solution as a square pyramidal monomer with a long axial Co−P bond. This 17‐electron species reacts in time of mixing with N2O to form L2Co2(μ‐OPEt3) (2)+3 OPEt3, the former the first example of phosphine oxide bridging two transition metals. The same products are formed from O2, and divalent cobalt persists even in the presence of excess oxidant. Species (2) catalyzes oxygen atom transfer (OAT) for generation of O=PEt3 from PEt3 from either N2O or O2. Bridging and terminal cobalt oxo intermediates are suggested, and the electron donor power, and potential redox activity of the dianionic pincer ligand is emphasized.
Tetrylones: An Intriguing Class of Monoatomic Zero‐valent Group 14 Compounds
Authors: Majhi Paresh Kumar , Sasamori Takahiro 
Published: February 2018

AbstractTetrylones (ylidones) represent a class of zero‐valent group 14 compounds with the general formula EL2 (E=C, Si, Ge, Sn, or Pb; L=neutral σ‐donating ligand), wherein the tetrel atom, E(0), possess its four valence electrons in the form of two electron lone pairs, and is moreover coordinated by two ligands (L) via donor‐acceptor interactions (L→E←L). This review focuses on the synthesis, structure, reactivity, and computational examination of the isolable heavier tetrylones (Si, Ge, Sn) that have been discovered recently. A comprehensive review on carbone chemistry is beyond the scope of this review. It should also be noted that tetrylones contain two different types of lone pairs, that is, one that exhibits p‐type and one that exhibits s‐type characteristics. Different behavior should thus be expected when these lone pairs react with Lewis acids.
Highly Efficient Photocatalytic System Constructed from CoP/Carbon Nanotubes or Graphene for Visible‐Light‐Driven CO2 Reduction
Authors: Fu Zi‐Cheng , Xu Rong‐Chen , Moore Joshua T. , Liang Fei , Nie Xiao‐Cun , Mi Chen , Mo Jiang , Xu Yong , Xu Quan‐Qing , Yang Zhi , Lin Zhe‐Shuai , Fu Wen‐Fu 
Published: February 2018

AbstractVisible‐light‐driven conversion of CO2 to CO and high‐value‐added carbon products is a promising strategy for mitigating CO2 emissions and reserving solar energy in chemical form. We report an efficient system for CO2 transformation to CO catalyzed by bare CoP, hybrid CoP/carbon nanotubes (CNTs), and CoP/reduced graphene oxide (rGO) in mixed aqueous solutions containing a Ru‐based photosensitizer, under visible‐light irradiation. The in situ prepared hybrid catalysts CoP/CNT and CoP/rGO show excellent catalytic activities in CO2 reduction to CO, with a catalytic rates of up to 39 510 and 47 330 μmol h−1 g−1 in the first 2 h of reaction, respectively; a high CO selectivity of 73.1 % for the former was achieved in parallel competing reactions in the photoreduction of CO2 and H2O. A combination of experimental and computational studies clearly shows that strong interactions between CoP and carbon‐supported materials and partially adsorbed H2O molecules on the catalyst surface significantly improve CO‐generating rates.
Palladium‐Catalyzed Asymmetric Allylic Alkylation of 4‐Substituted Isoxazolidin‐5‐ones: Straightforward Access to β2,2‐Amino Acids
Authors: Nascimento de Oliveira Marllon , Arseniyadis Stellios , Cossy Janine 
Published: February 2018

AbstractWe report here an unprecedented and highly enantioselective palladium‐catalyzed allylic alkylation applied to 4‐substituted isoxazolidin‐5‐ones. Ultimately, the process provides a straightforward access to β2,2‐amino acids bearing an all‐carbon quaternary stereogenic center in great yields and a high degree of enantioselectivity.
Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics
Authors: Koppermann Stefan , Cui Zheng , Fischer Patrick D. , Wang Xiachang , Ludwig Jannine , Thorson Jon S. , Van Lanen Steven G. , Ducho Christian 
Published: February 2018

AbstractMuraymycins are a subclass of antimicrobially active uridine‐derived natural products. Biological data on several muraymycin analogues have been reported, including some inhibitory in vitro activities toward their target protein, the bacterial membrane enzyme MraY. However, a structure–activity relationship (SAR) study on naturally occurring muraymycins based on such in vitro data has been missing so far. In this work, we report a detailed SAR investigation on representatives of the four muraymycin subgroups A–D using a fluorescence‐based in vitro MraY assay. For some muraymycins, inhibition of MraY with IC50 values in the low‐picomolar range was observed. These inhibitory potencies were compared with antibacterial activities and were correlated to modelling data derived from a previously reported X‐ray crystal structure of MraY in complex with a muraymycin inhibitor. Overall, these results will pave the way for the development of muraymycin analogues with optimized properties as antibacterial drug candidates.
Regularity for Shape Optimizers: The Nondegenerate Case
Authors: Kriventsov Dennis , Lin Fanghua 
Published: February 2018

AbstractWe consider minimizers of

urn:x-wiley:0010-3640:media:cpa21743:cpa21743-math-0001

where F is a function strictly increasing in each parameter, and is the kth Dirichlet eigenvalue of Ω. Our main result is that the reduced boundary of the minimizer is composed of C1,α graphs and exhausts the topological boundary except for a set of Hausdorff dimension at most n – 3. We also obtain a new regularity result for vector‐valued Bernoulli‐type free boundary problems.© 2018 Wiley Periodicals, Inc.