bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biodiversity conservation, consistency, and Mus musculus
Authors: Rohwer Yasha , Palmer Clare , Searle Jeremy B. 
Published: December 2024

AbstractThe house mouse (Mus musculus) is often thought of as a pest species in biological conservation, in agriculture, and in urban areas. As a result, populations are frequently targeted for control and eradication. However, M. musculus has notable within‐species biodiversity: it has genetically, morphologically, and behaviorally distinct subpopulations. Conserving biodiversity is usually considered the paramount goal of conservation biology, not least because biodiversity is claimed to have intrinsic value. But the biodiversity in mouse populations is often overlooked. In particular, conservationists do not call for the unique diversity represented by threatened mouse populations to be protected. This is illustrative of the inconsistent valuing of biodiversity in conservation. If biodiversity is intrinsically valuable, then it should be valued; however, it reveals itself. And yet, in examples presented here, unique populations of house mice with clear biodiversity value are threatened by eradication campaigns on islands and by changing agricultural practices on the Swiss–Italian border. The inconsistent valuing of biodiversity in the case of M. musculus raises important questions about whether the intrinsic value of biodiversity in conservation is, in practice, conditional on other implicit assumptions.
Comparing NIRA and Traditional Network Approaches: A Study Case With Antisocial Personality Disorder Traits
Authors: Machado Gisele Magarotto , Skjeldal Knut Erik , Grønnerød Cato , de Carvalho Lucas de Francisco 
Published: December 2024

ABSTRACTObjectiveThis study explores the NodeIdentifyR algorithm (NIRA) as a novel network analysis method for examining Antisocial Personality Disorder (ASPD) traits.MethodsUsing a sample of 2230 Brazilian adults (aged 18–73 years) who responded to ASPD‐related factors of the Personality Inventory for DSM‐5 (PID‐5), we applied NIRA to an ASPD network and compared its results with traditional network analysis methods.ResultsOur findings revealed that deceitfulness emerged as the most central trait across both methodologies. NIRA provided additional insights, indicating that simulated decreases in the likelihood of irresponsibility reduced the presence of other traits, while a simulated increase in deceitfulness amplified the likelihood of other ASPD pathological traits.ConclusionsOur results suggest that traditional network centrality measures converge with NIRA's simulated increase results, but NIRA's simulated decrease provides additional information not captured by traditional centrality estimates. We recommend further research to validate these findings across different psychopathologies and refine NIRA use in clinical settings. The insights from this study could serve as a foundation for developing targeted interventions and enhancing our understanding of ASPD trait dynamics.
Neighbourhood Deprivation and Gestational Diabetes Mellitus in Arizona From the AzPEARS Study
Authors: Parra Kimberly L. , Farland Leslie V. , Harris Robin B. , Toro Matthew , Furlong Melissa 
Published: December 2024

ABSTRACTBackgroundThe maternal population residing in rural areas, tribal lands or near the United States‐Mexico border are at high risk for adverse pregnancy complications, notably gestational diabetes mellitus (GDM). Few studies have considered the socioeconomic status (SES) attributes of neighbourhoods on maternal health during gestation. Given that the national and global rate of GDM is rising, this analysis moves beyond individual‐level factors and investigates the role of neighbourhood deprivation on GDM risk.ObjectiveTo investigate the relationship between neighbourhood deprivation and risk of GDM using Arizona state birth records.MethodsThis population‐based study of singleton live births (N = 481,113) utilised birth certificates from 2014 to 2020 from the AzPEARS study. Using American Community Survey (5‐year data) linked to 2010 US Census tracts, a composite neighbourhood deprivation index (NDI) score (continuous and quartiles) was derived from 8 socioeconomic indicators. Risk ratios (RR) and 95% confidence intervals (95% CI) were used to examine the association between NDI and GDM risk, adjusting for maternal age, maternal education, race/ethnicity, parity, rurality, and birth year.ResultsThe state‐wide incidence of GDM was 7.8% (n = 37,636) with variation by neighbourhoods (4% to 12%). GDM risk was highest for Native Americans (17.6%), Asian/Pacific Islanders (13.7%) and Hispanic/Latinas (8.3%). Compared to mothers living in areas with the lowest quartile of NDI, mothers living in neighbourhoods with the highest deprivation had an adjusted risk ratio of 1.21 for developing GDM (95% CI 1.18, 1.26).ConclusionsWe observed that neighbourhood deprivation was positively associated with a higher risk of GDM for each increase in quartile. These results suggest that NDI, a proxy for neighbourhood socioeconomic status, may contribute to GDM risk. Identifying high‐risk neighbourhoods for place‐based interventions targeting the most vulnerable birthing populations may be an effective strategy in the prevention of GDM.
Effective Government and Regional Technological Innovation: Evidence From 284 Cities in China
Authors: Fan Hongmin , Liang Chen 
Published: December 2024

ABSTRACTBased on the exogenous shock of incorporating environmental performance into local officials' evaluations, this paper manually collects and collates publicly available data on environmental target constraints (constraints on government environmental indicators for the coming period) from city government work reports as well as panel data from 284 cities in China from 2003 to 2018, and adopts the DID model to explore the impact of local government environmental target constraints on technological innovation after the implementation of the environmental target responsibility system. Our analysis reveals the following key aspects. First, local government environmental target constraints can significantly enhance the quantity of technological innovation, and the conclusion is robust and reliable. Second, the mechanism test shows that local government environmental target constraints can significantly increase the probability of local governments setting soft constraints on economic growth targets, increasing local investment in science and education, and improving the intensity of environmental regulation to promote regional technological innovation. Third, local government environmental target constraints can more effectively promote technological innovation in cities with low fiscal pressure, weak local government competition, and higher level of economic development. Further analysis finds that the autonomous constraint on the environmental target of local government can promote effectively green substantive innovation. This research highlights the crucial role of environmental policy in influencing sustainable technological progress by demonstrating how local government environmental target constraints can act as a stimulus for technological innovation, especially green innovation.
When issues matter: A Survey Experiment with Local Leaders
Authors: Borgeat Quentin 
Published: December 2024

AbstractParties and politicians strategically shape their electoral campaigns by meticulously selecting which issues to highlight, sometimes emphasizing specific aspects of these issues to exploit electoral opportunities. This assertion, derived from the issue yield theory, represents a unified vision of valence and positional issues. While this vision considers one aspect of the issue emphasis debate, the issue yield theory has yet to investigate the moderating influence of issue saliency on its predictions. I address this gap by employing innovative data on party leaders. The findings from a survey experiment involving Swiss local politicians (N = 693) demonstrate that issue saliency indeed moderates the issue yield mechanism, influencing party leaders' choices regarding issue emphasis. This underscores the pivotal role of issue saliency and emphasizes the need to account for it in both the issue yield literature and broader contexts.
Attacking Muslim Minority Women Online
Authors: Topidi Kyriaki 
Published: December 2024

Abstract
Against continuing attempts in Europe to draw an “essentialized” picture of Muslims as a group characterized by foreignness, backwardness, threat, and cultural incompatibility with core European values, this article focuses on the implications of a “racialized” representation of Muslims online, placing emphasis on women. An intersectional analysis of the impact of online hate speech is justified by the fact that this category of persons experience harm as a consequence of the interaction of their gender, religious affiliation, and ethnic origin as identity markers that single them out as “targets” for online hate speech. Taking into account the exponential growth of online hate speech targeting Muslims, the aim of the analysis is to show the need for an intersectional approach to anti-Muslim hatred online, especially in connection with the harm that such speech creates for women. By securitizing Muslim communities, online hate speech sets the basis for serious limitations on the freedom of expression, freedom of association, and political participation of a vulnerable segment of contemporary European societies.
A Symbol of ‘Gender Transformation’: Cross-Dressing in Female Tanci of Late Imperial China
Authors: Chen Jingyi 
Published: December 2024

Abstract
Tanci was one of the most popular literary forms among classical Chinese women writers, emerging in the middle of the Ming dynasty (1368–1644) and becoming extremely prominent during the Qing dynasty (1636–1912). This article explores five tanci stories centred on female-to-male cross-dressing inspired by Judith Butler’s performative theory. It discusses the varied applications of it by the authors and uncovers the commonalities hidden between the differences. In these works, cross-dressing is a common symbol of an attempt to cross the boundaries of gender identity and personal values outside the home. The meaning given to this symbol by female writers is a form of escape from their limited social living spaces. Their stories reflect their efforts to experience the same freedom and personal values outside the home as men had in Confucian society at the time. However, their resistance conforms to the existing social constructs of gender.
Adding Eltrombopag to Intensive Immunosuppressive Therapy Helps Adult Patients Catch up Pediatric Patients in Severe Aplastic Anemia
Authors: Yang Bixi , Wang Leyu , Fu Lingling , Wu Runhui , Ma Jie , Chen Miao , Han Bing 
Published: December 2024

Aim: To evaluate the differences of efficacy and survival between adults and children patients with severe aplastic anemia receiving intensive immunosuppressive therapy (IST) ± eltrombopag.
Methods: The clinical data of patients with SEVERE APLASTIC ANEMIA receiving IST ± eltrombopag between 2013 and 2022 were analyzed retrospectively. Baseline characteristics, hematological response, overall survival (OS), event-free survival (EFS), relapse, and clonal evolution in those treated with IST alone or IST+ eltrombopag were compared between adult (aged &gt;18 years) and pediatric (aged ≤18 years) patients.
Results: A total of 366 patients were included, including 141 adults and 225 children. For IST alone, adult patients had a similar overall response rate (ORR, 76% vs.75%, P=1.000) but a lower complete response rate (CRR, 31% vs. 48%, P=0.048) than pediatric patients at 12 months. Adult patients had lower OS (84.9±3.9% vs. 96.9±2.2%, P=0.007) and EFS (66.4±5.1% vs. 79.7±5.3%, P=0.047) than pediatric patients. After adding eltrombopag, the ORR was higher in adult patients than pediatric patients (89% vs. 73%, P=0.027) and the CRR was similar in two groups (54% vs. 50%, P=0.614). The OS and EFS in adults improved significantly and were similar to those in pediatric patients (91.4±4.2% vs. 96.7±1.8%, P=0.081 and 75.1±6.3% vs. 72.3±4.7%, P=0.834, respectively). Adults had similar relapse rates as children, either with or without eltrombopag (P&gt;0.05). Adult patients had significant higher clonal evolution rates than pediatric patients, either in IST alone group (9.2% vs. 1.4%, P=0.040) or in IST+ eltrombopag group (5.5% vs. 0%, P=0.017).
Conclusions: Adding eltrombopag to intensive IST improved the ORR, CRR, OS and EFS in adults more than it did in children. Adults had greater clonal evolution, regardless of the addition of eltrombopag.
Asparaginase Premedication with Hydrocortisone Decreases Hypersensitivity Reactions
Authors: Wegter Megan , Guerrettaz Ryan , Pan Amy , McCabe Kalen , Volmy Rebecca , Burke Michael J. 
Published: December 2024

Background:
Asparaginase is an integral component of leukemia and lymphoma treatment. However, hypersensitivity reaction (HSR) remains a common adverse event associated with administration of pegylated-asparaginase products. Previous clinical trials have demonstrated rates of HSR to pegylated E coli asparaginase (PEG) anywhere from 0.5% to 25%. At our institution, despite premedication with antihistamine medications such as diphenhydramine and famotidine, we have observed up to 30% of patients develop treatment-limiting HSR to PEG. Additionally, these reactions often overlap with nonallergic infusion reactions (IR), making it difficult to identify true HSR. There are now reports of universal premedication (UPM) adding hydrocortisone to the premedication regimen, however data to support this recommendation is lacking.
Methods:
We conducted a retrospective analysis evaluating the benefits of adding hydrocortisone to a two-drug premedication regimen of famotidine and diphenhydramine. Data was gathered via chart audit comparing pre-intervention with a two-drug regimen (diphenhydramine and famotidine) to post-intervention with a three-drug regimen of diphenhydramine, famotidine, and hydrocortisone. Analysis included patients with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LL) treated with a frontline PEG-containing treatment regimen. A one-year time interval was used to collect data for the pre- and post-intervention groups. All patients who received pegaspargase were reviewed. HSRs or IRs were reviewed independently to confirm and grade the reactions using Common Terminology Criteria for Adverse Events (CTCAE), v5 of allergic reactions. Hypersensitivity reactions observed included urticaria or any respiratory symptoms, such as sneezing, cough, tachypnea, bronchospasm, and/or oxygen desaturations. Other symptoms were considered consistent with IRs. Grade 2 reactions included the use of intravenous diphenhydramine, while grade ≥3 reactions included intramuscular epinephrine.
Results:
In 86 patients analyzed over a 2-year period, 48 were in the pre-intervention group given a two-drug regimen of diphenhydramine and famotidine prior to PEG or calaspargase. The rate of HSR in the pre-intervention group was 33% with an additional 12.5% experiencing IRs. The post-intervention group contained 38 patients who received a three-drug regimen with diphenhydramine, famotidine, and hydrocortisone. The incidence of HSR and IR were 16% and 13% respectively. Based on this data, rates of IR remained unchanged, while rates of HSR decreased significantly by approximately 50% (p-value 0.0411) with the addition of hydrocortisone to the pre-medication regimen.
Conclusions:
Universal premedication with the inclusion of hydrocortisone can significantly decrease HSR rates and serves as a useful strategy in the treatment of ALL/LL.
Effect of Pre- and Peri-Transplant Measurable Residual Disease Clearance in Patients with Myelodysplastic Neoplasm; A Referral Center Experience
Authors: Yodsuwan Ratdanai , Mott Sarah L , Vegel Andrew , Ravindra Aditya , Dhakal Prajwal , Sutamtewagul Grerk , Magalhaes-Silverman Margarida , Poonsombudlert Kittika 
Published: December 2024

Introduction
Measurable residual disease (MRD) has emerged as a potential prognostic marker for allogeneic stem cell transplant (HSCT) outcomes in various hematologic malignancies. However, the MRD status in myelodysplastic neoplasm (MDS) or myelodysplastic/myeloproliferative neoplasm (MDS/MPN), can be difficult to interpret due to heterogenous disease biology and unique limitations in each MRD measuring techniques. In comparison to B-cell acute lymphoblastic leukemia whose clearance of pre-HSCT MRD is considered essential, the data in MDS or MDS/MPN is less clear. As post-HSCT disease surveillance becomes more standardized, we also evaluated the effect of peri-HSCT MRD status on relapse-free and overall survival (RFS and OS) outcomes.
Methods
We reviewed records of adult patients who underwent HSCT for MDS or MDS/MPN at our institution between 2012-2023 and report the outcomes of patients between those who had undetectable MRD (MRD-) vs detectable MRD (MRD+) pre-HSCT and conducted a conditional analysis of outcomes based on MRD status at day+90 post-HSCT.
Results
We identified 38 and 55 patients in MRD- and MRD+ cohorts respectively. Baseline patient characteristics were similar between the cohorts, including age, Revised and Molecular International Prognostic Scores (IPSS-R & IPSS-M), and HSCT-related factors. The MRD+ cohort had inferior RFS (HR: 1.84, 95% CI: 1.09-3.12, p=0.02) but a statistically significant difference in OS was not evidenced (HR: 1.52, 95% CI: 0.88-2.61, p=0.14). After adjusting for % blasts at diagnosis, and conditioning intensity, MRD+ patients were found to be at 1.92 times increased risk of relapse or death (95% CI: 1.12-3.28, p=0.02). Additionally, increasing IPSS-M score was associated with poorer RFS (HR: 1.27, 95% CI: 1.01-1.59, p=0.04) and OS (HR: 1.52, 95% CI: 1.20-1.91, p&lt;0.01). On a conditional analysis of patients who were alive and in remission until day +90 post-HSCT, the pre-HSCT MRD status did not confer a statistically significant difference in RFS and OS if patients were able to achieve an MRD- status by day +90 post-HSCT.
Conclusion:
Pre- and peri-HSCT MRD testing may offer valuable survival prognostic information in patients with MDS and MDS/MPN and should be considered part of routine disease surveillance.
Concurrent Coronary Artery Disease and Immune Thrombocytopenia: A Systematic Review
Authors: Rozi Waail , Rahhal Alaa , Provan Drew , Shunnar Khaled , Najim Mostafa , Ahmed Ashraf , Al-Khabori Murtadha , Marashi Mahmoud , Alrasheed Mona , Osman Hani Yousif , Yassin Mohamed A 
Published: December 2024

Introduction
Coronary artery disease (CAD) management in the setting of immune thrombocytopenia (ITP) remains very challenging to clinicians as a reasonable balance between bleeding and thrombosis risks needs to be achieved, and the evidence guiding such management is scarce.
Methods
We conducted a systematic review following the PRISMA guidelines to summarize the available literature on the management and outcomes of CAD coexisting with ITP. We searched PubMed and Embase for studies published in English exploring CAD and ITP management until 05 October 2022. Two independent reviewers screened and assessed the articles for inclusion. Patients' characteristics, CAD treatment modalities, ITP treatment, and complications were reported.
Results
We identified 32 CAD cases, among which 18 cases were revascularized with percutaneous coronary intervention (PCI), 12 cases underwent coronary artery bypass graft surgery (CABG), and two cases were managed conservatively. More than 50% were men, with a mean age of 61 ± 13 years and a mean baseline platelet count of 52 ± 59 × 109/L. Irrespective of the revascularization modality, most patients were treated with either corticosteroids alone, intravenous immunoglobulins (IVIG) alone, or in combination. Among those who underwent PCI, two patients had bleeding events, and one patient died. Similarly, among those with CABG, one patient developed bleeding, and one patient died.
Conclusion
We found that revascularization with either PCI or CABG with the concurrent use of corticosteroids and/or IVIG for ITP was feasible, with an existing non-negligible risk of bleeding and mortality.
Improving Quality Outcomes through a Medicine Hospitalist-Driven Malignant Hematology Service
Authors: Lee Grace , Benyahia Steven , Syed Misbahuddin , Thakkar Hardik , Reich Richard R , Lochner James , Isenalumhe Leidy Lismeris , Hembree Timothy , Abdallah Enas , Verma Neha 
Published: December 2024

Background: In recent oncology care, the hospitalist model has emerged to reduce hospital stays, enhance inpatient capacity and alleviate burnout among oncologists, all while maintaining high quality inpatient care (Morris JC, et al. J Hosp Med. 2023;18(5):391-397). Oncology hospitalists-typically internal medicine physicians caring for acutely ill cancer patients-are shown to reduce hospital stays and improve inpatient capacity by enhancing communication, managing oncologic emergencies, and managing palliative care symptoms (Atlas KR, et al. Oncologist. 2020;25(12):e2006-e2009).
To our knowledge, Moffitt Cancer Center pioneers one of the first long-term, consistent and comprehensive studies into the hospitalist model for inpatient care, focusing on individuals with malignant hematology conditions and addressing their acute medical issues. The Heme Hospitalist service structure includes a hospitalist, a malignant hematology-trained advanced practice provider, and a malignant hematology-trained pharmacist to emphasize a comprehensive approach to drive high quality patient-centered care.
Objective: Evaluate the oncology hospitalist model on key quality outcomes within an inpatient malignant hematology setting through a single-center retrospective cohort study at Moffitt Cancer Center.
Methods: Electronic records were queried for patients &gt;18 years of age that were admitted to inpatient services in Heme A and B (traditional) or the co-managed Heme C and M service (hospitalist model implemented in Oct 2022). Three time periods of 13-month duration: Traditional (Aug 2020-Aug 2021), Transition (Sept 2021-Sept 2022), Hospitalist Model Intervention (Oct 2022-Oct 2023) were compared for admissions, discharges, Average Length of Stay (ALOS), Inpatient (IP) Bed Days Used, and 30-day unplanned readmission rate. ANOVAs compared LOS, case mix index, mortality risk, and severity of illness. We excluded patients that were transferred between services.
Results: 4,813 admissions occurred during the Aug 2020-Oct 2023 study period. ALOS decreased significantly amongst all services, as did the gap between Vizient expected LOS versus actual LOS. Although total IP Bed Days Used increased during the same time period, if there was no decrease in ALOS, 1,688 additional IP Bed Days would have been needed (as based on volume of discharges in the Hospitalist Model Intervention period). Severity of illness, age and risk of mortality increased significantly. There was no significant difference in unplanned readmission rate (Table 1).
Conclusion: Significant ALOS reduction despite increased severity, age, and risk of mortality, and no change in unplanned readmission rates highlight the success of the co-managed Heme C and M hospitalist service in addressing acute medical problems and shaping future developments in inpatient malignant hematology programs.