bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of a commercial order entry system on prescribing errors amenable to computerised decision support in the hospital setting: a prospective pre-post study
Authors: Pontefract Sarah K , Hodson James , Slee Ann , Shah Sonal , Girling Alan J , Williams Robin , Sheikh Aziz , Coleman Jamie J 
Published: March 2018

BackgroundIn this UK study, we investigated the impact of computerised physician order entry (CPOE) and clinical decision support (CDS) implementation on the rate of 78 high-risk prescribing errors amenable to CDS.MethodsWe conducted a preintervention/postintervention study in three acute hospitals in England. A predefined list of prescribing errors was incorporated into an audit tool. At each site, approximately 4000 prescriptions were reviewed both pre-CPOE and 6 months post-CPOE implementation. The number of opportunities for error and the number of errors that occurred were collated. Error rates were then calculated and compared between periods, as well as by the level of CDS.ResultsThe prescriptions of 1244 patients were audited pre-CPOE and 1178 post-CPOE implementation. A total of 28 526 prescriptions were reviewed, with 21 138 opportunities for error identified based on 78 defined errors. Across the three sites, for those prescriptions where opportunities for error were identified, the error rate was found to reduce significantly post-CPOE implementation, from 5.0% to 4.0% (P<0.001). CDS implementation by error type was found to differ significantly between sites, ranging from 0% to 88% across clinical contraindication, dose/frequency, drug interactions and other error types (P<0.001). Overall, 43/78 (55%) of the errors had some degree of CDS implemented in at least one of the hospitals.ConclusionsImplementation of CPOE with CDS was associated with clinically important reductions in the rate of high-risk prescribing errors. Given the pre-post design, these findings however need to be interpreted with caution. The occurrence of errors was found to be highly dependent on the level of restriction of CDS presented to the prescriber, with the effect that different configurations of the same CPOE system can produce very different results.
Improving medication adherence in patients with cardiovascular disease: a systematic review
Authors: Fuller Rosemary Hines , Perel Pablo , Navarro-Ruan Tamara , Nieuwlaat Robby , Haynes Robert Brian , Huffman Mark D 
Published: March 2018

ObjectiveTo evaluate and compare the effect of interventions for improving adherence to medications for atherosclerotic cardiovascular disease (ASCVD) secondary prevention.MethodsWe extracted eligible trials from a 2014 Cochrane systematic review on adherence for any condition. We updated the search from CENTRAL, Medline, Embase, PsycINFO, CINAHL, Sociological Abstracts and trial registers through November 2016. Study reports needed to be from a randomised controlled trial, incorporate participants identified as having ASCVD and interventions aimed at improving adherence to medicines for secondary prevention of ASCVD and measure both adherence and a clinical outcome. Two reviewers independently determined the eligibility of studies, extracted data and conducted a narrative synthesis.ResultsWe identified 17 trials (n=17 448 participants). Most trials had high risk of bias in at least one domain. The intervention group adherence rates ranged from 44%to99% and the comparator group adherence rates ranged from 13% to 96%. Three distinct interventions reported improvements in both adherence and clinical outcomes: short message service (65% vs 13% of participants with high adherence in the intervention vs control group), a fixed-dose combination pill (86% vs 65% adherence, risk ratio of being adherent, 1.33; 95% CI 1.26 to 1.41) and a community health worker-based intervention (97% in the intervention group compared with 92% in the control group; OR=2.62, 95% CI 1.32 to 5.19).ConclusionsWe identified three interventions that demonstrated improvements in adherence and clinical outcomes. Ongoing, longer-term trials will help determine whether short-term changes in adherence can be maintained and lead to differences in clinical events.
Increase in fluoroscopic radiation dose in successive sessions of multistage Onyx embolization of brain arteriovenous malformations compared with the first session
Authors: Sheen Jae Jon , Jiang Yuan Yuan , Kim Young Eun , Maeng Jun Young , Kim Tae-Il , Lee Deok Hee 
Published: March 2018

Background and purposeOnyx embolization is a treatment for brain arteriovenous malformations (AVMs). However, multistage embolization usually involves the presence of radiodense Onyx cast from the previous sessions, which may influence the fluoroscopic radiation dose. We compared the fluoroscopic dose between the initial and final embolization sessions.Materials and methodFrom January 2014 to September 2016, 18 patients underwent multistage Onyx embolization (more than twice) for brain AVMs. The total fluoroscopic duration (minutes), dose–area product (DAP, Gy×cm2), and cumulative air kerma (CAK, mGy) of both the frontal and lateral planes were obtained. We compared the frontal and lateral fluoroscopic dose rates (dose/time) of the final embolization session with those of the initial session. The relationship between the injected Onyx volume and radiation dose was tested.ResultsThe initial and final procedures on the frontal plane showed significantly different fluoroscopic dose rates (DAP: initial 0.668 Gy×cm2/min, final 0.848 Gy×cm2/min, P=0.02; CAK: initial 12.7 mGy/min, final 23.1 mGy/min, P=0.007). Those on the lateral plane also showed a similar pattern (DAP: initial 0.365 Gy×cm2/min, final 0.519 Gy×cm2/min, P=0.03; CAK: initial 6.2 mGy/min, final 12.9 mGy/min, P=0.01). The correlation between the cumulative Onyx volume (vials) and radiation dose ratio of both planes showed an increasing trend (rho 0.4325–0.7053; P=0.0011–0.0730).ConclusionOwing to the automatic exposure control function during fluoroscopy, successive Onyx embolization procedures increase the fluoroscopic radiation dose in multistage brain AVM embolization because of the presence of radiodense Onyx mass.
Deconstructing the Energy Consumption of the Mobile Page Load
Authors: Cao Yi , Nejati Javad , Wajahat Muhammad , Balasubramanian Aruna , Gandhi Anshul 
Published: March 2018

Modeling the energy consumption of applications on mobile devices is an important topic that has received much attention in recent years. However, there has been very little research on modeling the energy consumption of the mobile Web. This is primarily due to the short-lived yet complex page load process that makes it infeasible to rely on coarse-grained resource monitoring for accurate power estimation.
We present RECON, a modeling approach that accurately estimates the energy consumption of any Web page load and deconstructs it into the energy contributions of individual page load activities. Our key intuition is to leverage low-level application semantics in addition to coarse-grained resource utilizations for modeling the page load energy consumption. By exploiting fine-grained information about the individual activities that make up the page load, RECON enables fast and accurate energy estimations without requiring complex models. Experiments across 80 Web pages and under four different optimizations show that RECON can estimate the energy consumption for a Web page load with an average error of less than 7%. Importantly, RECON helps to analyze and explain the energy effects of an optimization on the individual components of Web page loads.
Tomographic Node Placement Strategies and the Impact of the Routing Model
Authors: Pignolet Yvonne-Anne , Schmid Stefan , Tredan Gilles 
Published: March 2018

Fault-tolerant computer networks rely on mechanisms supporting the fast detection of link failures. Tomographic techniques can be used to implement such mechanisms at low cost: it is often sufficient to deploy a small number of tomography nodes exchanging probe messages along paths between them and detect link failures based on these messages. Our paper studies a practically relevant aspect of network tomography: the impact of the routing model.
While the relevance of the routing model on path diversity and hence tomography cost is obvious and well-known on an anecdotal level, we lack an analytical framework to quantify the influence of different routing models (such as destination-based routing) exists. This paper fills this gap and introduces a formal model for asymmetric network tomography and a taxonomy of path routing models. This facilitates algorithmic reasoning about tomographic placement problems and quantifying the difference between routing models. In particular, we provide optimal and near-optimal algorithms to deploy a minimal number of asymmetric and symmetric tomography nodes for basic network topologies (modelled as graphs) under different routing model classes. Interestingly, we find that in many cases routing according to a more restrictive routing model gives better results: compared to a more general routing model, computing a good placement is algorithmically more tractable and does not entail high monitoring costs, a desirable trade-off in practice.
Pictures in Your Mind
Authors: Reichinger Andreas , Carrizosa Helena Garcia , Wood Joanna , Schröder Svenja , Löw Christian , Luidolt Laura Rosalia , Schimkowitsch Maria , Fuhrmann Anton , Maierhofer Stefan , Purgathofer Werner 
Published: March 2018

Tactile reliefs offer many benefits over the more classic raised line drawings or tactile diagrams, as depth, 3D shape, and surface textures are directly perceivable. Although often created for blind and visually impaired (BVI) people, a wider range of people may benefit from such multimodal material. However, some reliefs are still difficult to understand without proper guidance or accompanying verbal descriptions, hindering autonomous exploration.
In this work, we present a gesture-controlled interactive audio guide (IAG) based on recent low-cost depth cameras that can be operated directly with the hands on relief surfaces during tactile exploration. The interactively explorable, location-dependent verbal and captioned descriptions promise rapid tactile accessibility to 2.5D spatial information in a home or education setting, to online resources, or as a kiosk installation at public places.
We present a working prototype, discuss design decisions, and present the results of two evaluation studies: the first with 13 BVI test users and the second follow-up study with 14 test users across a wide range of people with differences and difficulties associated with perception, memory, cognition, and communication. The participant-led research method of this latter study prompted new, significant and innovative developments.
The MDA-9/Syntenin/IGF1R/STAT3 Axis Directs Prostate Cancer Invasion
Authors: Das Swadesh K. , Pradhan Anjan K. , Bhoopathi Praveen , Talukdar Sarmistha , Shen Xue-Ning , Sarkar Devanand , Emdad Luni , Fisher Paul B. 
Published: March 2018

Abstract
Although prostate cancer is clinically manageable during several stages of progression, survival is severely compromised once cells invade and metastasize to distant organs. Comprehending the pathobiology of invasion is required for developing efficacious targeted therapies against metastasis. Based on bioinformatics data, we predicted an association of melanoma differentiation-associated gene-9 [syntenin, or syndecan binding protein (SDCBP)] in prostate cancer progression. Using tissue samples from various Gleason stage prostate cancer patients with adjacent normal tissue, a series of normal prostate and prostate cancer cell lines (with differing tumorigenic/metastatic properties), mda-9/syntenin-manipulated variants (including loss-of-function and gain-of-function cell lines), and CRISPR/Cas9 stable MDA-9/Syntenin knockout cells, we now confirm the relevance of and dependence on MDA-9/syntenin in prostate cancer invasion. MDA-9/Syntenin physically interacted with insulin-like growth factor-1 receptor following treatment with insulin-like growth factor binding protein-2 (IGFBP2), regulating downstream signaling processes that enabled STAT3 phosphorylation. This activation enhanced expression of MMP2 and MMP9, two established enzymes that positively regulate invasion. In addition, MDA-9/syntenin-mediated upregulation of proangiogenic factors including IGFBP2, IL6, IL8, and VEGFA also facilitated migration of prostate cancer cells. Collectively, our results draw attention to MDA-9/Syntenin as a positive regulator of prostate cancer metastasis, and the potential application of targeting this molecule to inhibit invasion and metastasis in prostate cancer and potentially other cancers.
Significance: This study provides new mechanistic insight into the proinvasive role of MDA-9/Syntenin in prostate cancer and has potential for therapeutic application to prevent prostate cancer metastasis. Cancer Res; 78(11); 2852–63. ©2018 AACR.
Therapeutic Targeting of Sunitinib-Induced AR Phosphorylation in Renal Cell Carcinoma
Authors: Adelaiye-Ogala Remi , Damayanti Nur P. , Orillion Ashley R. , Arisa Sreevani , Chintala Sreenivasulu , Titus Mark A. , Kao Chinghai , Pili Roberto 
Published: March 2018

Abstract
Androgen receptor (AR) plays a crucial role in the development and progression of prostate cancer. AR expression has also been reported in other solid tumors, including renal cell carcinoma (RCC), but its biological role here remains unclear. Through integrative analysis of a reverse phase protein array, we discovered increased expression of AR in an RCC patient–derived xenograft model of acquired resistance to the receptor tyrosine kinase inhibitor (RTKi) sunitinib. AR expression was increased in RCC cell lines with either acquired or intrinsic sunitinib resistance in vitro. An AR signaling gene array profiler indicated elevated levels of AR target genes in sunitinib-resistant cells. Sunitinib-induced AR transcriptional activity was associated with increased phosphorylation of serine 81 (pS81) on AR. Additionally, AR overexpression resulted in acquired sunitinib resistance and the AR antagonist enzalutamide-induced AR degradation and attenuated AR downstream activity in sunitinib-resistant cells, also indicated by decreased secretion of human kallikrein 2. Enzalutamide-induced AR degradation was rescued by either proteasome inhibition or by knockdown of the AR ubiquitin ligase speckle-type POZ protein (SPOP). In vivo treatment with enzalutamide and sunitinib demonstrated that this combination efficiently induced tumor regression in a RCC model following acquired sunitinib resistance. Overall, our results suggest the potential role of AR as a target for therapeutic interventions, in combination with RTKi, to overcome drug resistance in RCC.
Significance: These findings highlight the therapeutic potential of targeting the androgen receptor to overcome RCC resistance to receptor tyrosine kinase inhibitors. Cancer Res; 78(11); 2886–96. ©2018 AACR.
Sp1 Plays an Important Role in Vascular Calcification Both In Vivo and In Vitro
Authors: Zhang Xinyu , Li Rui , Qin Xiaoteng , Wang Lei , Xiao Jie , Song Yu , Sheng Xi , Guo Mengqi , Ji Xiaoping 
Published: March 2018

Background

Vascular calcification and increased cardiovascular morbidity and mortality are closely related in patients with end‐stage renal disease and diabetes mellitus. Specific protein 1 (Sp1) is a transactivation molecule that plays a crucial role in the regulation of apoptosis, fibrosis, angiogenesis, and other pathological disorders. There is evidence that specific protein 1 (Sp1) directly stimulates the transcription of bone morphogenetic protein 2 (
BMP
2) and that
BMP
2 plays a key role in the calcification process in the
BMP
2–expressing F9 cell model system. Here, we investigated whether Sp1 plays an important role in vascular calcification and its potential regulatory mechanism in vascular calcification.

Methods and Results

In this study, vascular calcification was induced in male Wistar rats by administration of nicotine (25 mg/kg) and vitamin D3 (300 000 IU/kg). These rats were randomly selected for treatment with adenovirus harboring Sp1 knockdown gene or empty virus. The mechanism of Sp1 in vascular smooth muscle cells cultured in high phosphate medium was studied. Based on our findings, the Sp1 gene silencing or inhibition improved calcium deposition, which was partly achieved by inhibiting phenotype switch, apoptosis, and matrix vesicle release of vascular smooth muscle cells. Moreover, Sp1 can activate
BMP
2 transcription by binding to the Sp1‐binding element of the
BMP
2 promoter.

Conclusions

Overall, elevated Sp1 exerts a pro‐apoptotic effect, promoting
BMP
2 transcription and further accumulating vascular calcification. Proper and timely regulation of Sp1 expression may be a potential strategy for treatment of aging, end‐stage renal disease, and diabetic‐related macrovascular disease treatment.
Tout Fait Maison: A Law Code Crafted by the Eighteenth Century Jewry of Metz
Authors: Herman Shael 
Published: March 2018

Abstract
This inquiry examines Le Recueil des Loix, Coutumes, et Usages Observes par les Juifs de Metz. Evocative of the medieval German Sachsenspiegel, the volume’s detailed regulations supply a rich portrait of a Jewish community in Alsace-Lorraine during the turbulent final decades of the ancien regime. While France evolved during these decades from feudalism to democracy, the Jews transitioned from serfs main-mortables or royal chattels to citizenship. Ideals of the emerging French democracy were imprinted upon the Code Napoleon (1805), a distinctively anti-feudal, secular expression of French citizens’ newfound autonomy. In contrast, the Recueil originated in an act of will on the part of the Jews’ overlords. In accordance with royal orders, it was deposited in the records of the royal court at Metz in about 1742; royal judges and members of the bar consulted the Recueil in all manner of disputes involving Jewish litigants and Jewish law. The Recueil, as the handiwork of eighteenth century Alsatian Jews, was unique in engrafting Jewish law and ethics upon French law of the ancien regime.
Rabbinic Inquiry (Hakirah) as the Place Rabbinic and Academic Talmudic Discourse Meet: The Case of “Two Hold a Cloak”
Authors: Blankovsky Yuval 
Published: March 2018

Abstract
This paper explores the common ground and differences between academic and rabbinic Talmudic hermeneutics. It does this by situating R. Elhanan Bunem Wasserman’s (1874–1941) inquiry pertaining to the much beloved Talmudic debate over “Two Hold a Cloak” within the context of the critical academic commentary on that Talmudic discourse.
Relationship between Aerosols, Hail Microphysics, and ZDR Columns
Authors: Ilotoviz E. , Khain A. , Ryzhkov Alexander V. , Snyder Jeffrey C. 
Published: March 2018

Abstract
Mechanisms of formation of differential reflectivity columns are investigated in simulations of a midlatitude summertime hailstorm with hailstones up to several centimeters in diameter. Simulations are performed using a new version of the Hebrew University Cloud Model (HUCM) with spectral bin microphysics. A polarimetric radar forward operator is used to calculate radar reflectivity and differential reflectivity ZDR. It is shown that ZDR columns are associated with raindrops and with hail particles growing in a wet growth regime within convective updrafts. The height and volume of ZDR columns increases with an increase in aerosol concentration. Small hail forming under clean conditions grows in updrafts largely in a dry growth regime corresponding to low ZDR. Characteristics of ZDR columns are highly correlated with vertical velocity, hail size, and aerosol concentration.
Scale-Dependent Background Error Covariance Localization: Evaluation in a Global Deterministic Weather Forecasting System
Authors: Caron Jean-François , Buehner Mark 
Published: March 2018

Abstract
Scale-dependent localization (SDL) consists of applying the appropriate (i.e., different) amount of localization to different ranges of background error covariance spatial scales while simultaneously assimilating all of the available observations. The SDL method proposed by Buehner and Shlyaeva for ensemble–variational (EnVar) data assimilation was tested in a 3D-EnVar version of the Canadian operational global data assimilation system. It is shown that a horizontal-scale-dependent horizontal localization leads to implicit vertical-level-dependent, variable-dependent, and location-dependent horizontal localization. The results from data assimilation cycles show that horizontal-scale-dependent horizontal covariance localization is able to improve the forecasts up to day 5 in the Northern Hemisphere extratropical summer period and up to day 7 in the Southern Hemisphere extratropical winter period. In the tropics, use of SDL results in improvements similar to what can be obtained by increasing the uniform amount of spatial localization. An investigation of the dynamical balance in the resulting analysis increments demonstrates that SDL does not further harm the balance between the mass and the rotational wind fields, as compared to the traditional localization approach. Potential future applications for the SDL method are also discussed.
Associations Between Comorbid Health Conditions and Quit Outcomes Among Smokers Enrolled in a State Quitline, Arizona, 2011-2016
Authors: Nair Uma S. , Bell Melanie L. , Yuan Nicole P. , Wertheim Betsy C. , Thomson Cynthia A. 
Published: March 2018

Objective: Smokers with comorbid health conditions have a disproportionate burden of tobacco-related death and disease. A better understanding of differences in quit rates among smokers with comorbid health conditions can guide tailoring of quitline services for subgroups. The objective of this study was to examine self-reported tobacco cessation rates among Arizona Smokers’ Helpline callers with chronic health conditions (CHCs) and/or a mental health condition (MHC). Methods: We analyzed data from quitline telephone callers (n = 39 779) who enrolled in and completed at least 1 behavioral counseling session (ie, coaching call). We categorized callers as CHC only (cardiovascular disease/respiratory-related/cancer; 32%), MHC only (eg, mood/anxiety/substance dependence; 13%), CHC + MHC (25%), or no comorbid condition (30%). We assessed 30-day abstinence at 7-month follow-up for 16 683 clients (41.9%). We used logistic regression analysis to test associations between comorbidity and quit outcomes after controlling for relevant variables (eg, nicotine dependence). Results: Overall quit rates were 45.4% for those with no comorbid condition, 43.3% for those with a CHC only, 37.0% for those with an MHC only, and 33.3% for those with CHC + MHC. Compared with other groups, the CHC + MHC group had the lowest odds of quitting (adjusted odds ratio = 0.60; 95% confidence interval, 0.52-0.69). Conclusion: Having a comorbid condition was associated with lower quit rates, and smokers with co-occurring CHCs and MHCs had the lowest quit rates. Quitlines should evaluate more intensive, evidence-driven, tailored services for smoking cessation among callers with comorbid conditions.
Indigenous Peoples’ Right to Communication with Identity in Argentina, 2009–2017
Authors: Doyle María Magdalena , Siares Emilse 
Published: March 2018

Argentine Law 26.522 on Audiovisual Communication Services recognized, among other things, the right to communication for indigenous peoples. The cases of three indigenous radio stations in northern Argentina reveal the limits and possibilities of this normative transformation and the challenges to indigenous media posed by the changes in communications policy since the 2015 change of government. La ley argentina 26.522 de Servicios de Comunicación Audiovisual reconoció, entre otras cuestiones, el derecho a la comunicación de los pueblos originarios. Los casos de tres emisoras de radio indígenas en el norte de Argentina revelan los límites y posibilidades de esta transformación normativa y los desafíos a los medios indígenas generados a partir de los cambios en política de comunicaciones desde el cambio de gobierno de 2015.