bluuebunny/crossref_metadata_2025_split huggingface dataset:
Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury
Authors: Bain William , Olonisakin Tolani , Yu Minting , Qu Yanyan , Hulver Mei , Xiong Zeyu , Li Huihua , Pilewski Joseph , Mallampalli Rama K. , Nouraie Mehdi , Ray Anuradha , Ray Prabir , Cheng Zhenyu , Shanks Robert M. Q. , St. Croix Claudette , Silverstein Roy L. , Lee Janet S. 
Published: February 2019

AbstractThrombocytopenia is associated with worse outcomes in patients with acute respiratory distress syndrome, which is most commonly caused by infection and marked by alveolar–capillary barrier disruption. However, the mechanisms by which platelets protect the lung alveolar–capillary barrier during infectious injury remain unclear. We found that natively thrombocytopenic Mpl−/− mice deficient in the thrombopoietin receptor sustain severe lung injury marked by alveolar barrier disruption and hemorrhagic pneumonia with early mortality following acute intrapulmonary Pseudomonas aeruginosa (PA) infection; barrier disruption was attenuated by platelet reconstitution. Although PA infection was associated with a brisk neutrophil influx, depletion of airspace neutrophils failed to substantially mitigate PA-triggered alveolar barrier disruption in Mpl−/− mice. Rather, PA cell-free supernatant was sufficient to induce lung epithelial cell apoptosis in vitro and in vivo and alveolar barrier disruption in both platelet-depleted mice and Mpl−/− mice in vivo. Cell-free supernatant from PA with genetic deletion of the type 2 secretion system, but not the type 3 secretion system, mitigated lung epithelial cell death in vitro and lung injury in Mpl−/− mice. Moreover, platelet releasates reduced poly (ADP ribose) polymerase cleavage and lung injury in Mpl−/− mice, and boiling of platelet releasates, but not apyrase treatment, abrogated PA supernatant–induced lung epithelial cell cytotoxicity in vitro. These findings indicate that while neutrophil airspace influx does not potentiate infectious lung injury in the thrombocytopenic host, platelets and their factors protect against severe pulmonary complications from pathogen-secreted virulence factors that promote host cell death even in the absence of overt infection.
Imaging-Genomic Study of Head and Neck Squamous Cell Carcinoma: Associations Between Radiomic Phenotypes and Genomic Mechanisms via Integration of The Cancer Genome Atlas and The Cancer Imaging Archive
Authors: Zhu Yitan , Mohamed Abdallah S.R. , Lai Stephen Y. , Yang Shengjie , Kanwar Aasheesh , Wei Lin , Kamal Mona , Sengupta Subhajit , Elhalawani Hesham , Skinner Heath , Mackin Dennis S. , Shiao Jay , Messer Jay , Wong Andrew , Ding Yao , Zhang Lifei , Court Laurence , Ji Yuan , Fuller Clifton D. 
Published: February 2019

Purpose Recent data suggest that imaging radiomic features of a tumor could be indicative of important genomic biomarkers. Understanding the relationship between radiomic and genomic features is important for basic cancer research and future patient care. We performed a comprehensive study to discover the imaginggenomic associations in head and neck squamous cell carcinoma (HNSCC) and explore the potential of predicting tumor genomic alternations using radiomic features. Methods Our retrospective study integrated whole-genome multiomics data from The Cancer Genome Atlas with matched computed tomography imaging data from The Cancer Imaging Archive for the same set of 126 patients with HNSCC. Linear regression and gene set enrichment analysis were used to identify statistically significant associations between radiomic imaging and genomic features. Random forest classifier was used to predict the status of two key HNSCC molecular biomarkers, human papillomavirus and disruptive TP53 mutation, on the basis of radiomic features. Results Widespread and statistically significant associations were discovered between genomic features (including microRNA expression, somatic mutations, and transcriptional activity, copy number variations, and promoter region DNA methylation changes of pathways) and radiomic features characterizing the size, shape, and texture of tumor. Prediction of human papillomavirus and TP53 mutation status using radiomic features achieved areas under the receiver operating characteristic curve of 0.71 and 0.641, respectively. Conclusion Our exploratory study suggests that radiomic features are associated with genomic characteristics at multiple molecular layers in HNSCC and provides justification for continued development of radiomics as biomarkers for relevant genomic alterations in HNSCC.
Does the clinical information play a role in the magnetic resonance diagnostic confidence analysis of ovarian and deep endometriosis?
Authors: Saba Luca , Ajossa Silvia , Ledda Giuseppe , Balestrieri Antonella , Schirru Federica , De Cecco Carlo Nicola , Suri Jasjit S , Melis Gian Benedetto , Lavra Francesco , Guerriero Stefano 
Published: February 2019

Objective:
Some recent studies have explored how the experience in the observers change their performance in the endometriosis detection using MRI but the effects of the clinical information remains uncertain. The purpose of this study was to assess the effect of the clinical information in the diagnostic confidence in the MRI diagnosis of endometriosis.

Methods and materials:
Institutional Review Board was obtained. This study is compliant to STARD method. 80 patients (mean age 32 years; range 19 – 46 years) who had undergone MRI study and surgery for suspected endometriosis were retrospectively evaluated. MRI exams were performed with a 1.5 T scanner and the following five locations were assessed: ovary, anterior compartment, vaginal fornix, utero-sacral ligaments, and Rectum\Sigmoid\Pouch of Douglas. Data sets were evaluated twice on a 5-point scale by four radiologists with different level of expertise; the first time blinded to the clinical information and the second time, after 3 months together with the clinical chart. Statistical analysis included receiver operating characteristics curve analysis, the Cohen weighted test and sensitivity, specificity, positive predictive value, negative predictive value, accuracy, LR+ and LR–.

Results:
A total of 140 localization of endometriosis (47 endometriomas and 93 endometriotic nodules) were found. The pairwise comparison demonstrated that in all cases the presence of clinical information improved the Az value. The concordance analysis indicated a mixed pattern from modest agreement (weighted κ value 0.556 for anterior compartment) to excellent agreement values (weighted κ value 0.867 for ovarian endometriomas).

Conclusion:
The results of our study suggest that clinical information is useful in diagnosing endometriosis in general anterior compartment, but not in other locations. Less experienced radiologists (resident) may benefit from it at utero-sacral ligaments or Rectum\Sigmoid\Pouch of Douglas.

Advances in knowledge:
In this era of sometimes indiscriminate use of diagnostic methods, it is important to emphasis the context for interpretation of diagnostic results. Our paper confirms that clinical information is useful in diagnosing endometriosis.
Dog health and demographic surveillance survey in Western Kenya: Demography and management practices relevant for rabies transmission and control
Authors: Kwoba Emmah N. , Kitala Philip , Ochieng Linus , Otiang Elkanah , Ndung’u Robert , Wambura Gati , Hampson Katie , Thumbi S.M. 
Published: February 2019

Background: Domestic dogs transmit 99% of the estimated 59,000 human rabies deaths occurring globally annually. To achieve the global target of zero human deaths from rabies by 2030, effective mass dog vaccination campaigns that break rabies transmission cycles in dog populations are required. This study describes the design of a dog health and demographic surveillance study established within a human health and demographic surveillance study in Western Kenya. Using baseline data from the dog cohort study, we quantify demographic parameters and describe management practices relevant for rabies transmission. Methods: All dogs in 1213 households participating in a linked human and animal health syndromic surveillance study were recruited. Data on household demographics, dog ownership, dog age and sex ratios, reproductive indices, rabies vaccination, management practices, dog movement and health status were collected at least monthly. Results: 460 of 1213 (38%) of the study households owned dogs (mean 2 dogs/household), and 526 (70%) of those without dogs had owned dogs previously. 802 dogs were recruited into the study, more than half (52%) of those with known ages were ≤ 1 year old. The dog:human ratio in the study population was 1:7, the dog density 54 dogs/km2, and the female: male dog sex ratio was 1:1.3. Rabies vaccination was low (5% coverage), and only 48 (12%) male dogs and 13 (5%) female dogs were castrated and spayed, respectively. Dogs were predominantly local breed (99%), mainly kept for security purposes, almost always (97%) left to scavenge for leftovers and 61% roamed freely. Conclusion: Low vaccination coverage, unrestricted dog movement, and high dog population turnover with a large proportion of dogs below one-year-old support endemic rabies circulation in this population. These gaps present opportunities for the design of effective dog rabies control plans to break rabies transmission cycles in this part of Kenya.
Supporting parent–child bonding through relationship-based community music programmes: Description of an Elemental Music Pedagogy programme with young, at-risk mothers and their children
Authors: Savage-Kroll Camille 
Published: February 2019

Abstract
Through numerous studies in the field of brain and learning research we know that the first years of a child’s life play a crucial developmental role and that actively engaging with music in these early years can have positive effects on overall development. Music addresses all aspects of intelligence – the cognitive, emotional, social, mental and the spiritual. It touches, unites and encompasses every facet of being human. Attachment Theory emphasizes the primary importance of secure bonding and attunement in children’s development. In Germany, parent–child music groups have boomed since the 1990s. In recent years there has been a movement in the area of Elemental Music Pedagogy towards creating community music groups for parents of babies or young children with the explicit goal of strengthening the parent–child bond. In partnership with organizations supporting young mothers in hardship, music courses are being developed and offered for this specific group. This article aims to present the theoretical groundwork of such groups and examines recent practical examples.
Par delà l’Art Brut, L’Enfant bleu comme espace en liberté
Authors: ROJAT Fanny 
Published: February 2019

Fanny Rojat, dont la thèse porte sur les écrits bruts, explore les liens possibles entre art brut, art-thérapie et pratique artistique, celle d’Orion dans L’Enfant bleu : montrant les liens parfois ambigus entre les différentes positions et recherches, elle souligne combien pour Henry Bauchau, l’expérience de la personne singulière en l’artiste dépasse et transcende toute théorie ou mouvance, gênant la simple assimilation de ce singulier à une généralité.
Dossier de traduction
Authors: BAUCHAU Henry 
Published: February 2019

Poèmes inédits (1997-2009), avant-textes du recueil Tentatives de Louange (Actes Sud, 2011). Une version inédite du poème « Tentatives de louange » (version antérieure de « Exercice de louange ») traduit en anglais (versions de Will Stone et d’Anne Davenport), en allemand( versions de Ute Heidmann et d’Anne Neuschäfer), en néerlandais (Kris Lauwerys), en italien (Adriane Marchetti), en espagnol (Teresa Lozano-Sanpedro), en roumain (Rodica Pop), en ukrainien (Ivan Riabitchiï), en russe (Natalia Tiukalova et Oxana Dubnyakova).
Puissance auto-affective et pathétique de l’écriture poétique
Authors: DUBOIS Matthieu 
Published: February 2019

Henry Bauchau se dit « écrivain par espérance ». L’extrême-Orient, chez lui, incarne une voie où peut se renouveler une certaine spiritualité, liée à la déprise des certitudes idéologiques et un retour à l’émerveillement de la condition incarnée, lieu de notre finitude comme condition d’un épanouissement de soi. La puissance auto-affective et pathétique de la parole poétique fonde donc ce que l’on peut appeler une « poéthique », c.-à-d. une esthétique dont l’horizon est la transmutation de la violence de l’éprouver en puissance afin d’accroître le potentiel de vie du sujet tant scripteur que lecteur. C’est ainsi que la vie peut révéler sa puissance originaire d’adhésion à elle-même, laquelle correspond à une puissance d’amour, par-delà la rugosité inhérente de l’existence.
Le temps de l’imaginaire et le temps de l’écriture
Authors: WILLEMART Philippe 
Published: February 2019

Cette étude générique des variantes du poème « Œdipe à Colone » et du roman Œdipe sur la route analyse l’élaboration littérature dans sa temporalité. On envisage d’abord la reprise des personnages et leur processus de nomination. Puis on observe les différentes campagnes d’écriture, et la manière dont se met en jeu une interaction entre la pulsion propre de l’écriture et le dialogue avec l’horizon d’attente.
Marche, couleur et écriture. Le « chemin du rouge » à travers Œdipe, Clios, Antigone et Richard Long
Authors: D’ALIGNY Marie-Claire 
Published: February 2019

Couleur, marche et écriture : tels sont les éléments qui passionnent Marie-Claire d’Aligny dans son propre parcours et qui lui ont ait croiser l’œuvre d’Henry Bauchau. Elle propose une lecture d’Œdipe sur la route et Antigone en dialogue avec l’installation Champ d’ocre de Richard Long exposée à la Chapelle d’Avignon en été 2011. Elle relève le motif de la trace, et l’importance de la couleur associée au mouvement.
Investigation of the Effects of Different Bias Angles of Stitching on Seam Performance of Wool Suits
Authors: Öztaş Hande , Gürarda Ayça 
Published: February 2019

AbstractWool suits are always preferred due to their warmth retention in cool weather, comfort, and aesthetic features. Seams are very important for the quality of wool suits. The tensile characteristics of seamed fabric change with the change of fabric bias angle. This study aimed to investigate the effects of different seam angles with various stitch densities on the seam strength and the seam breaking extension of wool suit stitches. In this study, seam strength and seam-breaking elongation at different bias angles were investigated for the stitches of trousers and jackets of wool suits. As is known, in the production of trousers and jackets, the seams are applied not only in the direction of the weft and warp but also in the different bias angles at the crotch area and arm hole seams. Six wool fabrics with different structural properties were chosen as experimental samples. Fabrics were cut at 0°, 30°, 45°, 60°, and 90° angles and then sewn with three different stitch densities (3, 4, and 5 stitches/cm), with lockstitch stitch type for each fabric angle. Therefore, 90 differently seamed fabric samples were prepared. The results indicated that seams prepared with 0°,45° and 90° bias angles give the highest seam strength and that 30°, 45°, and 60° bias angles give the highest seam-breaking elongation values all over the samples. Seams prepared with 30° and 60° bias angles give the lowest seam strength, and 0° and 90° bias angles give the lowest seam-breaking elongation values all over the samples.
Literature review: nutritional factors influencing academic achievement in school age children
Authors: Prangthip Pattaneeya , Soe Yee Mon , Signar Jean Faulan 
Published: February 2019

Abstract

Background and objective
Adolescence is a transition period involving tremendous physical, psychological and cognitive growth. For appropriate growth of adolescents in these aspects, a correct quantity and quality of nourishment is required, as a lack of such nourishment among adolescents can lead to various degrees of malnutrition, which may have implications on their health as well as their academic achievements.

Materials and methods
This review examines the research topics around factors that influence the nutritional status of adolescent students which can affect their academic performance.

Results
Some of the vital factors include knowledge and attitude about nutrition, eating behaviour, physical activity, socio-economic status of the family, the surrounding environment at school and home, the frequency and timing of meals, nutritional contents and amount of food intake.

Conclusion
Students who consume a balanced diet perform better in exams, show better behaviour as well as attendance at school and get their assigned tasks done more thoroughly compared with those who do not consume a balanced diet.
IGF-1 assessed by pubertal status has the best positive predictive power for GH deficiency diagnosis in peripubertal children
Authors: Inoue-Lima Thais H. , Vasques Gabriela A. , Scalco Renata C. , Nakaguma Marilena , Mendonca Berenice B. , Arnhold Ivo J.P. , Jorge Alexander A.L. 
Published: February 2019

Abstract

Background
When evaluating peripubertal short stature patients, the interpretation of insulin-like growth factor 1 (IGF-1) levels based on chronological age (CA) can be inaccurate due to the influence of sex steroids and, presently, there is no evidence to support the assessment of IGF-1 values according to bone age (BA) and pubertal status (PS). Our objective was to assess the discriminatory performance of IGF-1 levels based on CA, BA and PS in the diagnosis of growth hormone (GH) deficiency.

Methods
We evaluated IGF-1 levels from 154 peripubertal short stature patients classified as GH deficient (GHD, n=23) or non-GHD (n=131). IGF-1 was assayed by a chemiluminescent immunometric assay and transformed into standard deviation scores (SDS) according to CA (IGF-1-SDS-CA), BA (IGF-1-SDS-BA) and PS (IGF-1-SDS-PS).

Results
The performances of IGF-1-SDS-CA, IGF-1-SDS-BA and IGF-1-SDS-PS in the receiver operator characteristics (ROC) curves were similar. There were greater accuracy and specificity of IGF-1-SDS-PS (98.4% and 93.3%, respectively) and IGF-1-SDS-BA (92.7% and 90.1%, respectively) when compared to IGF-1-SDS-CA (65.6% and 69.5%, respectively). The post-test probability of the IGF-1-SDS was also improved when compared to PS and BA – 44.8% (IGF-1-SDS-PS), 16.8% (IGF-1-SDS-BA) and 5.1% (IGF-1-SDS-CA), with similar negative predictive values.

Conclusions
The evaluation of IGF-1 levels based on CA has a higher sensitivity than those based on BA or PS, which justify its use as a screening tool. Additionally, IGF-1 assessed by PS has the best positive predictive power for GHD diagnosis in peripubertal age and could reduce the necessity of a second GH stimulation test.
A dohányzás visszaszorítása a Facebook segítségével a 14–35 éves korosztály körében
Authors: Pócs Dávid , Kovács Róbert , Óvári Tímea , Erdős Csaba , Kelemen Oguz 
Published: February 2019

Abstract: Introduction: The possibility of successful smoking cessation is increased by early initiation. Therefore, promoting smoking cessation at early age (especially among 14–35-year-olds) has a key role in reducing tobacco use prevalence. Facebook is one of the most popular websites among adolescents and young adults which can be used for age-specific smoking cessation support. Aim: Our research seeks to reveal the effects of a Facebook page on smoking habits, smoking cessation knowledge and attitudes among 14–35-year-olds. Method: An online survey was conducted among the 3278 followers of the author’s Facebook page. The questionnaire was completed by 332 people among 14–35-year-olds. We analysed demographic data, smoking habits, the usage frequency and duration of the Facebook page as well as changes in smoking habits, smoking cessation knowledge and attitudes. Results: The average age was 22.57 ± 5.08 years. The examined population consisted of 65% currently smokers, 12% former smokers and 23% non-smokers. Significantly more people reported a positive change in their smoking habits and smoking cessation attitudes among smokers who used the Facebook page more frequently and with longer duration (p<0.05). The habit and attitude changes were significantly higher among smokers who plan to quit smoking (p<0.01). Nevertheless, we also observed attitude changes between 12–25% among smokers who did not plan to quit. Among non-smokers, the positive attitude changes were significantly higher in the low-educated population who live in villages (p<0.01). Conclusion: This Facebook page had a positive effect on smoking habits, smoking cessation knowledge and attitudes among 14–35-year-olds. The contents of the Facebook page could be used to prevent smoking and support smoking cessation among 14–35-year-olds. Orv Hetil. 2019; 160(6): 220–227.
OKUL ÖNCESİ EĞİTİM ÖĞRETMENLERİNİN KAYNAŞTIRMA EĞİTİMİNDE ÖZ-YETERLİK ALGILARI VE HİZMETİÇİ EĞİTİM GEREKSİNİMLERİ: BİR KARMA YÖNTEM ÇALIŞMASI
Authors: Sönmez Nesrin , ALPTEKİN Serpil , BIÇAK Bayram 
Published: February 2019

Karma yöntemle
desenlenmiş bu çalışmada okul öncesi eğitim öğretmenlerinin (OÖEÖ), kaynaştırma eğitiminde öz-yeterlik algıları
ile kaynaştırma eğitimi öz-yeterlikleri ve hizmetiçi eğitim gereksinimlerine
yönelik görüşlerini belirlemek amaçlanmıştır. Bu
araştırmada veriler yakınsayan paralel desen (NİC+NİT) kullanılarak toplanmıştır. Çalışmanın nicel boyutu
katılımcılarını, Antalya’da
görevli 478 OÖEÖ; nitel boyutu katılımcılarını amaçlı örnekleme yöntemiyle seçilmiş
17 OÖEÖ
oluşturmuştur. Araştırmanın nicel verileri “Katılımcı Bilgi
Formu” ve “Özel Gereksinimli Çocukların Kaynaştırılmasına
Yönelik Öğretmen Yeterliği (ÖGÇKÖY)” ölçeği ile toplanmıştır. Nitel veriler
için ise “Katılımcı Bilgi Formu” ve
“Okul Öncesi Kaynaştırma Eğitimi Odak Grup Görüşmesi Formu” kullanılmıştır. Araştırmanın nicel olarak toplanan
verileri istatistiksel olarak, nitel olarak toplanan veriler betimsel analiz
yoluyla analiz edilmiştir. İstatistiksel analiz için SPSS, nitel yöntemle
toplanan verilerin analizi için Nvivo nitel veri analiz yazılımı kullanılmıştır. Çalışma sonunda öğretmenler, ÖGÇKÖY ölçeğinin “özel gereksinimli
çocuklara yönelik bilgi” boyutunda en yüksek düzeyde (X̄=3,997) yeterli bulurken, “özel gereksinimli çocuklara öğretim
sunma konusu güven” boyutunda en düşük düzeyde (X̄=3,175) kendilerini yeterli bulmuşlardır. OÖEÖ’nin kaynaştırma eğitiminde
yeterliklerine ilişkin odak grup görüşmesi verilerine bakıldığında, bilgi,
planlama, uygulama ve öz nitelikler olmak üzere yeterlik alanlarının 4 tema
altında toplandığı ve öğretmenlerin kaynaştırma eğitiminde kendilerini yetersiz
olarak değerlendirdikleri bulunmuştur. Hizmetiçi eğitim gereksinimlerine ilişkin olarak görüşlerinin, engel türleri ve özellikleri, program hazırlama, etkinlik planlama, sınıf
yönetimi, sosyal kabulü sağlama, engelli çocuğa beceri kazandırma, 2013
Programı eki ve aile ile iletişim olmak üzere 8 alt temadan oluştuğu
görülmüştür. Araştırma sonuçları diğer araştırmaların sonuçları ile birlikte
tartışılmış ve önerilerde bulunulmuştur.
Role of Optical Coherence Tomography in the Diagnosis of Spontaneous Coronary Artery Dissection
Authors: TERADA KOSEI 
Published: February 2019

Spontaneous coronary artery dissection (SCAD) is an infrequent and often missed diagnosis among patients with acute coronary syndrome (ACS), especially young healthy females. Unfortunately, SCAD can result in significant morbidity, such as ischemia and infarction. Currently, there has been a surge in the diagnosis of SCAD due to the widespread use of new intracoronary imaging modalities, especially optical coherence tomography (OCT).However, no specific guidelines exist concerning appropriate treatment for SCAD. Moreover, the role of intracoronary imaging with OCT has yet to be fully established. The aim of our review is to provide a comprehensive contemporary update of SCAD; the epidemiology, etiology, diagnosis, management and cardiovascular outcomes are reviewed from the viewpoint of OCT.