bluuebunny/crossref_metadata_2025_split huggingface dataset:
DYNAMICS OF CLINICAL AND IMMUNOLOGICAL INDICATORS IN COMPLEX TREATMENT OF CANDIDA-ASSOCIATED PERIODONTITIS
Authors: Мирсаева Фания , Mirsaeva Faniya , Ханов Тимур , Hanov Timur 
Published: August 2019

Subject. The problem of complex treatment of candida-associated periodontitis is considered. The authors propose a two-component probiotic, which, due to antagonistic activity regarding periodontal pathogenic infection and fungi of the genus Candida, leads to the relief of the inflammatory process, positive dynamics and stabilization of immunological parameters.
The aim ― to evaluate the dynamics of clinical and immunological parameters in the complex treatment of candida-associated periodontitis with an average degree of quantitative seeding of periodontal pockets using a two-component probiotic.
Methodology. A clinical and laboratory examination of three groups (I, II, III) of patients with Candida-associated periodontitis with an average degree of quantitative contamination of periodontal pockets (> 3 <6 CFU / ml) was carried out. Patients I groups were prescribed the well-known complex treatment including an antimycotic drug, patients II groups included a two-component probiotic locally in the treatment complex, and patients III groups locally and per os. The state of the oral mucosa was assessed, PMA, PI, OHI - S were determined, and indicators of cellular and humoral immunity were examined.
Results. The study made it possible to establish that the inclusion of a two-component probiotic in the complex of treatment of candida-associated periodontitis with an average degree of quantitative contamination of periodontal pockets with fungi of the genus Candida contributes to the relief of the inflammatory process, an increase in phagocytosis, the metabolic activity of neutrophils, the concentration of immunoglobulins A, lysozyme levels, and a decrease in the concentration of immunoglobulins. G, positive dynamics of other indicators of immunity and their stabilization.
Conclusions. The inclusion of a two-component probiotic from two strains in the complex treatment of chronic hepatitis C associated with fungi of the genus Candida contributes to the rapid relief of the inflammatory process in periodontal tissues, positive dynamics and stabilization of cellular and humoral immunity parameters.
EVALUATION OF THE RESULTS OF COMPLEX TREATMENT OF LICHEN PLANUS OF THE ORAL MUCOSA WITH THE USE OF AUTOLOGOUS PLASMA OR HUMAN PLACENTA EXTRACT
Authors: Усманова Ирина , Usmanova Irina , Герасимова Лариса , Gerasimova Larisa , Хисматуллина Зухра , Hismatullina Zuhra , Гранот Игаль , Granot Yigal , Ахмеров Ренат , Akhmerov Renat , Абдрахманова Елена , Abdrahmanova Elena , Хуснаризанова Рауза , Khusnarizanova Rauza , Усманов Ирек , Usmanov Irek , Мудрик Ольга , Mudrik Olga 
Published: August 2019

Subject. On the basis of a comprehensive dental examination, the clinical condition of the oral mucosa was assessed. With the use of laboratory research methods, the parameters of the microta state from the surface of erosion, the state of local immunity of the oral fluid, as well as anamnesis data with the assessment of somatic status, clinical blood analysis, ultrasound examination of the state of internal organs, the tactics of the complex of phased local and General therapy were studied. In clinical conditions, the analysis of minimizing pain, the nature of the epithelialization of erosive elements and regeneration of the oral mucosa. Using the analysis of laboratory methods, the pronounced antibacterial effect, increase of local immunity factors of the oral cavity, a qualitative decrease in chronic inflammation in the oral mucosa and in the body as a whole, as well as a decrease in the depressive state of the patient were evaluated. Proven and proved the efficiency of application of this complex treatment in the early and late periods.
The purpose ― is to draw the attention of practicing dentists and related specialists to the need for an effective phased scheme of diagnostic and therapeutic and preventive measures in patients with lichen planus.
Material and methods. The article is based on the description of clinical observation of a patient with erosive-ulcerative form of lichen planus.
Results. The use of the proposed complex of step-by-step local injection methods on the oral mucosa and General measures by dermatologists, therapists, gastroenterologists in the erosive and ulcerative form of lichen planus contributes to a better acceleration of the epithelialization process, regeneration, reducing the signs of chronic inflammation, qualitative improvement of the somatic status and quality of life of patients.
Summary. The inclusion in the scheme of the complex of local and General therapeutic and preventive measures of erosive-ulcerative form of lichen planus by injection of autologous plasma (AP) and human placenta hydrolysate (HRH) is a more effective method of therapy in these patients.
FREQUENCY OF THE ORBITAL WALLS FRACTURES. A RETROSPECTIVE STUDY
Authors: Абдулкеримов Тимур , Abdulkerimov Timur , Мандра Юлия , Mandra Yuliya , Герасименко Владислав , Gerasimenko Vladislav , Цех Дмитрий , Tzekh Dmitriy , Саматов Никита , Samatov Nikita , Мандра Екатерина , Mandra Ekaterina , Жегалина Наталья , Gegalina N. , Епишова Анна , Yepishova Anna 
Published: August 2019

Midfacial fractures are presented by wide range of different patterns and severity. Orbital walls fractures have a special place in the structure of traumatic craniofacial injuries. Referring foreign authors, fractures of external rims and internal orbital walls are presented in more than 40 % of all bony injuries of facial skeleton. And referring Russian authors frequency of zygomaticomaxillary complex and isolated maxillary fractures presented by 12 and 8 % respectively. Furthermore complex anatomy of the orbit and proximity of the globe can occur some difficulties in diagnostics and treatment process of these patients. Today there are two main mechanisms of orbital walls fractures development – Blow-out, when fracture caused by increasing of intraorbital pressure, and Force-transmission, when force applied to external orbital rims transmits to a weaker orbital walls. Moreover in young patients Trapdoor mechanism is actual, which results in entrapment of soft tissues in the fracture line. Often there is an inferior rectus muscle entrapment and that is serious complication, when immediate surgery is required.
The article deals with issues of anatomical construction of orbit and orbital trauma epidemiology based on statistics of neurosurgical department of Central city clinical hospital № 23, Yekaterinburg, for 2017.
THE EFFICACY OF PLATELET GROWTH FACTORS (PRP) IN THE COMPLEX TREATMENT OF TMJ MALFUNCTIONS
Authors: Скоробогатько Кирилл , Skorobogatko Kirill , Петрикас Инга , Petrikas Inga , Соколова Ирина , Sokolova Irina 
Published: August 2019

Background. Joint pain is often associated not only with disc displacement but also due to the level of inflammatory mediators in the synovial fluid. Injections of platelet growth factor not only expand the joint cavity, performing a purely mechanical function but also create a high concentration of growth factor in the synovial fluid, which favorably affects the cartilage tissue, joint capsule, ligamentous apparatus.
Objectives ― to study the effectiveness of platelet growth factor in the complex treatment of patients with TMJ malfunctions.
Methods. A clinical examination of two groups of patients (50 people) aged 18 to 67 years with a malfunctions of TMJ was conducted. Were used in all patients in the complex: splint therapy, myogymnastics, and manual traction drive. For the first group (25 people), concentrated growth factor in the liquid phase (PRP) was used in the treatment. For the second group (PRP) was not used. The patients were divided into two groups randomly.
Results. The results of the study were carried out according to the following criteria: pain in TMJ with a maximum opening of the mouth, protrusion, laterotruzii, sound phenomena in TMJ, myofascial pain (palpation), the presence of deviation/deflection of the lower jaw, incisional distance.
Conclusions. 1. Complex therapy, including splint therapy, myogymnastics, manual traction of the disc, the use of platelet growth factor, showed good results in the treatment of TMJ malfunctions. 2. According to all the studied criteria (pain in TMJ with a maximum opening of the mouth, protrusion, laterotruzii, sound phenomena in TMJ, myofascial pain (palpation), the presence of deviation/deflection of the lower jaw), the most effective result of treatment was obtained after 1 month.
STUDY OF MICROSCOPIC IMPRINTS OF PURULENT WOUNDS OF THE MAXILLOFACIAL REGION IN CHILDREN WHEN USING THE OINTMENT WITH FURACILIN, LIDOCAINE AND DIBUNOLUM
Authors: Чуйкин Сергей , Chuykin Sergey , Хасанов Тимур , KXASANOV Timur , Мустафин Тагир , Mustafin Tagir , Макушева Наталья , Makusheva Natal'ya , Изосимов Артем , IZOSIMOV Artem , Викторов Сергей , Victorov Sergey , Рахмангулов Рустам , Rahmangulov Rustam 
Published: August 2019

Importance ― study of microscopic imprints of the wound surface of purulent wounds in inflammatory diseases of the maxillofacial region in children.
Objectives ― cytological research of microscopic imprints of purulent wounds in inflammatory diseases of the maxillofacial region in children
Methods. The study included 60 children from 5 to 16 years old who were treated for abscesses and phlegmon of the maxillofacial area. Patients were divided independently into 2 groups. The main group included 30 children. For their treatment we used ointment with Furacilin, Lidocaine and Dibunolum. The control group included 30 patients. For their treatment used ointment Levomecol. To compare the effectiveness of the healing of purulent wounds in the main and control groups, we studied cytology of microscopic imprints of purulent wounds at 3, 7 and 10 days.
Results. A microscopic examination of the imprints of the wound surface of the control group on the 3 day revealed a predominantly inflammatory type of cytogram, on day 5, the type of cytorgamy was replaced by inflammatory-regenerative, which persisted on the 7th day of the study. Microflora was represented in small quantities. In the main group, in the study of microscopic imprints on the 3ed day, inflammatory-regenerative type of cytogram was also observed. On the 7th, the cytogram shifted to the regenerative type. Cell infiltrate was poor, containing macrophages and lymphocytes. Seeding by microorganisms was not observed.
Conclusions. Thus, based on the morphological studies of microscopic imprints of the wound surface, we recommend the use of ointment with Furacilin, Lidocaine and Dibunolum for the complex treatment of abscesses and phlegmon of the maxillofacial region. Since the ointment reduces the time of wound healing and reduces bacterial contamination of the wound.
EFFICIENT COMPUTATION OF SOBOL’ QUASI-RANDOM GENERATOR
Authors: Vesel Timotej 
Published: August 2019

Purpose of the study: The quasi-Monte Carlo method is an essential tool for modeling and analyzing various complex problems in engineering, physical sciences, finance, and business. The crucial element of the method is a sequence of deterministic quasi-random values, which is often obtained by using the Sobol’ quasi-random generator. The purpose of this study is to consider the time complexity of generating the Sobol’ sequence.
Methodology: Algorithms for determining the Sobol' sequence have been studied. The algorithms have been implemented in the Python programming language.
Main Findings: It is established that this sequence can be generated in the linear time provided that generated numbers are based on 32-bit or 64-bit integers. The main result of the paper is the algorithm, which enables this time-bound.
Applications of this study: The study can be applied in engineering, physical sciences, finance, and business.
Novelty/Originality of this study: It is shown that Sobol’ sequence can be generated in linear time.
Modification of surface layers by high energy treatment
Authors: Vereschagin M. N. , Tselueva S. N. , Tseluev M. Yu. 
Published: August 2019

Exposure to laser radiation leads to a change in the temperature field of the substance being treated. The nature of heating, which is determined by the rate of change of temperature, temperature gradients, the time to reach the temperatures of structural and phase transitions, is different depending on the properties of the material being processed and the processing conditions.When modifying the surface layers by high-energy processing by changing the power and time of exposure to laser radiation, you can get a wide range of structural states of the treated surface areas of the material.It is shown that the shape of TVP diagrams and cooling curves of precision alloys on the surface of a two-layer metal system after heating them with laser radiation are determined by the competition of two processes acting in opposite directions: an increase in the driving force of the crystallization process with an increase in supercooling and a decrease in the surface of atoms.The method of surface modification by moving laser radiation allows to obtain amorphous functional layers of precision alloys on the surface of metal products.
Analisis Fator-Faktor yang Berpengaruh terhadap Return On Investment (Studi Pada Lembaga Keuangan Syariah “Kita” Desa Demangan Kecamatan Siman Ponorogo)
Authors: Maharani Shinta 
Published: August 2019

Krisis ekologi yang sampai saat ini berlangsung seolah menggambarkan betapa sistem ekonomi membutuhkan pemikiran dan tindakan nyata. beberapa langkah strategis telah ditempuh baik skala besar yaitu pada tingkat Negara maupun skala kecil yaitu pada lembaga-lembaga keuangan mikro setempat. Langkah nyata yang dilakukan adalah memperkecil faktor resiko dalam investasi melalui skema “Return On Investment”. Berdasarkan hal tersebut, penelitian ini akan membahas Faktor-faktor yang mempengaruhi Return On Investment pada Lembaga Keuangan Syariah “Kita” Desa Demangan Kecamatan Siman Kabupaten Ponorogo. Penelitian ini dilakukan dengan menggunakan data primer dan data sekunder yaitu dengan pemberian kuisioner kepada para responden dan pengolahan data dari laporan keuangan. Dari populasi sebanyak 90 masyarakat yang mengajukan pinjaman, yang disetujui sebanyak 58 nasabah maka sampel ditetapkan sebanyak 58 responden pada Lembaga Keuangan Syariah ”KITA”. Analisis selanjutnya didasarkan pada laporan akuntansi keuangan yang telah dibukukan dan diolah pada Lembaga Keuangan Syariah ”KITA” dengan variabel yang digunakan Sistem Pengendalian Internal (X1) dan etika bisnis (X2). Hasil temuan penelitian ini menyatakan bahwa sistem pengendalian internal tidak berpengaruh terhadap Return on Investment, hal ini dikarenakan sistem pengendalian internal tidak berjalan dengan efektif, sehingga ROI tidak mampu dicapai. Sedangkan etika bisnis berpengaruh negative signifikan terhadap ROI, hal ini menunjukan bahwa semakin meningkat etika bisnis maka akan mengurangi kecenderungan kecurangan transaksi, sehingga ROI dapat tercapai. Sebaliknya semakin menurun etika bisnis maka akan meningkatkan kecenderungan kecurangan.
Treatment outcomes of Acute Appendicitis and associated factors among admitted patients with a diagnosis of Acute Abdomen in Debre Markos referral hospital, Amhara region, North West Ethiopia
Authors: Afenigus Abebe Dilie , Bayieh Agumas Mossie , Kassahun Berhanu 
Published: August 2019

Abstract
Introduction-

Acute abdomen is a sudden onset abdominal disease condition which often requires an immediate surgical intervention. Appendicitis is an inflammation of the vermiform appendix and is one of the most common causes of an acute abdomen in young adults. Appendicitis can cause severe periumbilical pain that radiates to the right lower quadrant, nausea, vomiting and anorexia. If left untreated, it can also cause appendiceal abscess, perforation and peritonitis.

Objective

- To assess treatment outcomes of Acute Appendicitis and associated factors among admitted patients with a diagnosis of acute abdomen in Debre Markos referral hospital from September 11/2018 to March 9/2019.

Methods and materials

- Institutional based cross sectional study was employed among 169 patients using a census sampling method. Data were collected from patient medical records, registration books and anesthesia charts available in the hospital by using checklist. Data was entered using Epi-data version 4.2 and analyzed by SPSS version 25 software. Logistic regression analysis was employed to describe the relationship between outcome and predictor variables.

Results -

Among 303 patients with a diagnosis acute abdomen, 169(55.7%) were developed acute appendicitis, of whom, 107(63.7%) were males and 62 (36.7%) were females. Among 169 patients who underwent appendectomy for treatment of acute appendicitis, 45(26.6%) of them were developed unfavorable treatment outcomes. The odds of unfavorable treatment outcomes for acute appendicitis was higher among patients who had elevated WBC count at the time of presentation [AOR=4.7; 95% CI (1.95, 11.35)] as compared with their counterparts. Similarly, those patients who had an intraoperative appendiceal abscess were more likely to have unfavorable treatment outcome for acute appendicitis [AOR= 3.8; 95% CI (1.61, 9.07)] as compared to those who didn’t have appendiceal abscess.

Conclusion and recommendation-

Nearly one-fourth of patients who underwent appendectomy for appendicitis treatment were developed unfavorable treatment outcomes. Elevated WBC count at the time of presentation and presence of intraoperative appendiceal abscess were the factors associated with unfavorable treatment outcome of acute appendicitis. Therefore, immediately evaluate patients having similar features with laboratory investigations is crucial.
Preoperative prognostic nutritional index predicts both short and long-term outcomes after liver resection for hepatocellular carcinoma.
Authors: Saito Yu , Imura Satoru , Morine Yuji , Ikemoto Tetsuya , Yamada Shinichiro , Shimada Mitsuo 
Published: August 2019

Abstract
Background
The aim of this study was to investigate the prognostic significance of the prognostic nutritional index (PNI) for both short and long term outcomes after liver resection for hepatocellular carcinoma (HCC).
Methods
162 (without any previous treatment) of 229 surgically treated HCC patients were retrospectively analyzed. The cut off value of the preoperative PNI was 45.0. Patients were divided into two groups, PNI low (n=76) and high (n=86) group.
Results
Among some immune parameters such as PNI, neutrophil to lymphocyte ratio (NLR) and aspartate aminotransferase (AST) to lymphocyte ratio (ALRI), PNI had most reliable parameters in terms with prediction of both short and long term outcomes. Preoperative PNI tended to correlate with low skeletal muscle mass (SMM). In short term outcomes, PNI low group were more likely to have postoperative complications. The disease-free survival rate in PNI low group was significantly worse than that in the PNI high group (20.5 vs. 48.7 %, 5 year SR, p=0.03). On multivariate analysis, Low PNI was an independent prognostic factor for disease free survival (HR 1.65, p= 0.04).
Conclusions
The preoperative PNI was the most significant prognostic factor for evaluating both short and long-term outcomes after liver resection for HCC.
The Effects of Two Exercise Modalities on Novel Cardiovascular Risk Factors in Overweight Women with Type 2 Diabetes: a Randomized Controlled Trial
Authors: Banitalebi Ebrahim , Faramarzi Mohammad , Ghahfarrokhi Majid Mardaniyan , Nasiri Samira 
Published: August 2019

Abstract
Background: The purpose of this study was to examine the effects of different exercise modalities (short sprint interval training (SIT) and combined aerobic + resistance training (A+R)) on novel cardiovascular risk factors (lipid accumulation product (LAP), Framingham risk score (FRS), atherogenic index of plasma (AIP), the metabolic syndrome severity scores (Mets score), visceral adipose index (VAI), body adipose index (BAI), triglyceride-glucose index (TyG index), triglyceride glucose-waist circumference (TyG-WC), triglyceride glucose-waist circumference (TyG-BMI), HOMA β-cell, and estimated glucose disposal rate (eGDR)) in overweight women with type 2 diabetes.
Methods: Fifty-two overweight females with type 2 diabetes (T2D) (aged 45-60 years, BMI > 30, hemoglobin A1c (HbA1c) ≥ 6.5 %) were assigned to either SIT (n = 17), combined training (n = 17), or control groups (n = 18). Intervention consisted of SIT or combined aerobic-strength training for 10 weeks.
Results: There were no significant changes in Mets in the SIT group after 10 weeks (p = 0.187). In addition, there were significant changes (improvements) in LAP (p < 0.001) and VAI (p = 0.002), FRS (p = 0.001), TyG index (p = 0.005), TyG-BMI (p = 0.012), TyG-WC (p < 0.001), AIP (p < 0.001), and eGDR (p = 0.001) in the combined training group after 10weeks, as compared to the baseline.
Conclusions: The results highlight that exercise training independent of the mode of training could be an effective strategy to improve some novel cardiovascular risk factors in women with type 2 diabetes.
Association between the polymorphism of MMP-1 gene with knee osteoarthritis risk: a meta-analysis
Authors: Lu Feifan , Zhang Qidong , wang weiguo , guo wanshou , liu pei 
Published: August 2019

Abstract
Background: The existing studies on the association between polymorphisms of Matrix metalloproteinase-1 (MMP-1) (-1607 1G/2G) (rs1799750) polymorphism and the risk of knee osteoarthritis (OA, a complex multifactorial disease and a major degenerative form of arthritis) in different populations have yielded conflicting findings.
Method: Literature search was performed in PubMed, Embase, Medline, Cochrane Library, Web of science, Google Scholar, CNKI and Wanfang database(From January 1990 to June 2019), and assessing this association by calculating odds ratios with 95% confidence intervals. Subgroup analyses stratified by ethnicity were also conducted. Statistical heterogeneity was quantitatively evaluated by X2 test with the significance set P<0.10 or I2>50%.
Result: Five case-control based studies (924 cases and 928 controls) were included. The results suggested that the MMP-1 (-1607 1G/2G) (rs1799750) gene polymorphisms were not associated with knee OA risk in all genetic models (Allele model OR =1.22, 95% CI: 0.72-1.76, p=0.615, Recessive model OR = 1.12, 95% CI: 0.70-2.15, p=0.486, and Dominant model OR = 1.14, 95%CI: 0.64-2.04, p=0.659, Figure 3-5)
Conclusions: There is no association between the polymorphism of MMP-1 (-1607 1G/2G) (rs1799750) polymorphism with the risk of knee osteoarthritis, a large number of studies may be necessary to verify this association in different populations and environmental factors.