bluuebunny/crossref_metadata_2025_split huggingface dataset:
Updating the study of perceptual mechanisms in the process of training cadets in Moscow regional branch of the Moscow university of the MIA of Russia named V. Ya. Kikot.
Authors: Иванов Роман , Ivanov Roman 
Published: June 2019

The article discusses relevance of the study of perceptual mechanisms in the process of training cadets in Moscow regional branch of the Moscow university of the MIA of Russia named V. Ya. Kikot. The author notices the necessity of taking under control (self-reflection) these perceptual mechanisms to get opportunity to change them for effective development cadet’s professional skills, systematization of perception mental processes. Besides understanding the specific of perception takes the key for awareness logic and mental processes another men. Trainee needs it for improvement their consciousness. In particular the author focuses attention on most important physiological and psychological problems of perception which appear during the actualization perceptual processes.
Also the article pays especial attention for disadvantages of the learning system which does not let understand the importance of perceptive process and use it.
After the author plans the system of learning perceptual processes and gives theoretical and practical foundation.
Exploring the role of school nurses in the prevention and management of childhood obesity
Authors: Dawe Natasha , Coward Melaine 
Published: June 2019

Objectives: The aim of this study is to explore the role of school nurses in the management and prevention of childhood obesity in primary school-aged children. Study design: The chosen paradigm for this research was qualitative and the methodology applied here was Participatory Action Research. A non-probability sample was recruited using pre-determined inclusion and exclusion criteria. Methods: Focus groups were used as their reflective nature enabled rich in-depth data collection to answer the research question. Two focus groups and one virtual focus group were held. Results: The findings from this research show that although school nurses feel they have a role in the prevention and management of childhood obesity in primary school-aged children they face several barriers in being able to achieve this. Conclusions: This research has highlighted a gap in the literature regarding the perception of the school nurse role by school nurses as well as by teachers and parents. This is an area where further study may have a positive impact on school nurses' ability to play a more leading role in public health.
The genetics of isolated and syndromic clubfoot
Authors: Sadler B. , Gurnett C. A. , Dobbs M. B. 
Published: June 2019

Purpose Congenital clubfoot is a serious birth defect that affects nearly 0.1% of all births. Though there is strong evidence for a genetic basis of isolated clubfoot, aside from a handful of associations, much of the heritability remains unexplained. Methods By systematically examining the genes involved in syndromic clubfoot, we may find new candidate genes and pathways to investigate in isolated clubfoot. Results In addition to the expected enrichment of extracellular matrix and transforming growth factor beta (TGF-β) signalling genes, we find many genes involved in syndromic clubfoot encode peroxisomal matrix proteins, as well as enzymes necessary for sulfation of proteoglycans, an important part of connective tissue. Further, the association of Filamin B with isolated clubfoot as well as syndromic clubfoot is an encouraging finding. Conclusion We should examine these categories for enrichment in isolated clubfoot patients to increase our understanding of the underlying biology and pathophysiology of this deformity. Understanding the spectrum of syndromes that have clubfoot as a feature enables a better understanding of the underlying pathophysiology of the disorder and directs future genetic screening efforts toward certain genes and genetic pathways. Level of evidence V
Challenging clubfeet: The arthrogrypotic clubfoot and the complex clubfoot
Authors: van Bosse H. J. P. 
Published: June 2019

Within the realm of clubfoot deformities, teratologic and complex (or atypical) clubfeet stand out as the most difficult. Exemplarities of the teratologic types of clubfoot are those associated with arthrogryposis multiplex congenita. Treatment of arthrogrypotic clubfoot deformities has been controversial; many different procedures have been advocated, with variable success rates. These clubfeet have a high recurrence rate, regardless of treatment type. Often, the high recurrence rate has led to a high repeat surgery rate, and poor outcomes. Treatment strategies should highlight care that avoids the development of a stiffened foot and allows for a variety of options to regain correction when a relapse occurs. Modifications of the Ponseti method for idiopathic clubfeet have been successful in managing the deformity. The equinocavus variant of the arthrogrypotic clubfoot should be distinguished from the classic clubfoot, as it requires a different treatment method. The equinocavus clubfoot is very similar to the complex or atypical clubfoot. The complex, or atypical, clubfoot also requires a different treatment strategy compared with the typical idiopathic congenital clubfoot. The complex clubfoot appears to be idiopathic in some cases and iatrogenic (due to slipping stretching casts) in others. Dr. Ponseti's modification of his protocol has been effective in treating the deformity. The high recurrence rate suggests the difficulty in maintaining the deformity after correction. The author's preferred treatment for each deformity is included, with an emphasis on minimally invasive methods. Level of Evidence Level V, expert opinion
Additional challenges in children with idiopathic clubfoot: Is it just the foot?
Authors: Lööf E. 
Published: June 2019

Purpose Treatment of idiopathic clubfoot (IC) has improved since the introduction of the Ponseti method. However, relapses are still common and primarily related to non-adherence to the brace regime. Our hypothesis was that IC might be more than just a structural deformity. Based on three studies, the aim of this paper was to provide an overview of findings regarding additional challenges within IC. Methods In total, 153 children with IC and 137 control children participated in the studies. The first study assessed gross motor skills in six motor tasks using the Clubfoot Assessment Protocol. The second and third studies surveyed neurodevelopmental difficulties (NDDs) using the Five to Fifteen (FTF) questionnaire and health-related quality of life (HRQoL) using the EuroQol-5D youth. Results A high percentage of gross motor deviations were found in children with IC compared with controls, and those correlated poorly with clubfoot severity and foot movement. Children with IC had a higher prevalence of NDDs on the FTF compared with the control group, including the domains: motor skills, perception and language. One-third of children with IC were defined as at risk of developmental disorders. In this subgroup, parents were less satisfied with the outcome of clubfoot treatment and the children reported worse HRQoL than those without NDDs. Conclusion The findings suggest additional challenges in children with IC, such as NDDs, apparently affecting both clubfoot treatment outcome and HRQoL. Thus, awareness of these challenges could be vital to further optimize treatment and support, for example, with regards to brace adherence. Level of Evidence II - Prognostic study
Anomáliák a felsőoktatás-finanszírozásban
Authors: Polónyi István 
Published: June 2019

A tanulmány a hazai felsőoktatás-finanszírozás néhány újabb történését vizsgálja meg, némi történelmi és nemzetközi kitekintéssel. Célja bemutatni azt, hogy a napjainkban tapasztalható anomáliák – mint például az újabb intézményi eladósodások és azok központi kisegítése (miközben a kancellári rendszer bevezetésével állítólag sikeres volt a felsőoktatás konszolidációja), elbocsátások egyes tudományegyetemeken, hirtelen tandíjemelés – mire vezethetők vissza.Az írás megállapítja, hogy a hazai felsőoktatás elmúlt tíz évét az állami források beszűkülése mellett a finanszírozási rendszer átalakulása jellemezte. Nemzetközi összehasonlításban a hazai felsőoktatás kormányzati forrásai (az állami támogatások aránya a GDP-hez viszonyítva) jelentősen elmaradnak a fejlett országok átlagától. A mindezek nyomán kialakult intézményi gazdálkodási nehézségeket a kormány a kancellári rendszer bevezetésével – s ezzel együtt a gazdasági autonómia radikális és az akadémiai (oktatási és kutatási) autonómia vele járó nem jelentéktelen korlátozásával –, valamint eseti, kézzel vezérelt konszolidációs pénzosztogatással próbálta kezelni. Az intézmények kondicionális helyzete azonban tartósan rossz, ami nyilvánvalóan a minőség rovására megy, hiszen az intézmények az idősebb és tapasztaltabb oktatók elbocsátására kényszerülnek, és az oktatás feltételei is romlanak. Félő, hogy az állami források bővülése és a gazdálkodási szabadság kiszélesítése nélkül a helyzet tovább romlik. Egyre nyilvánvalóbban irreálissá válik a kormányzati stratégiának nevezett anyag azon célkitűzése, amely szerint minden magyar felsőoktatási intézmény világszínvonalú kell legyen azokban a diszciplínákban, amelyek a saját kiemelt területéhez tartoznak.
Orte des Selbststudiums 2018
Authors: Vogel Bernd 
Published: June 2019

Zusammenfassung
Das HIS-Institut für Hochschulentwicklung hat im Frühjahr 2018 eine Befragung unter Studierenden zum Selbststudium durchgeführt. Unter Selbststudium wird das studienbezogene Lernen außerhalb von Lehrveranstaltungen verstanden. Ziel war es, empirische Daten darüber zu erheben, an welchen Orten und mit welchem Zeitaufwand Studierende außerhalb von Lehrveranstaltungen lernen. Im Ergebnis zeigt sich, dass aktuell die beliebteste Lernwelt der Studierenden das Homeoffice ist: zwei Drittel der Studierenden lernen vor allem zu Hause, ein Drittel in der Hochschule. Innerhalb der Hochschulen ist die Bibliothek der beliebteste Lernort. Allerdings lernt eine große Gruppe von Studierenden kaum oder gar nicht in der Bibliothek, ein kleinerer Anteil dagegen sehr intensiv (mehr als 8 Stunden/Woche). Die digitalen Angebote der Hochschulbibliotheken werden von rund 80 % der Studierenden genutzt, überwiegend zu Hause. Das Lernverhalten der Studierenden ist je nach Fächergruppe sehr heterogen.
Agreeing in number: Verbal plural suppletion and reduplication
Authors: Thornton Abigail 
Published: June 2019

Abstract
Verbal suppletion for participant number has recently attracted theoretical attention (Bobaljik & Harley 2017; Toosarvandani 2016). I show that cross-linguistically, participant number is marked by suppletion and reduplication and is part of a broader phenomenon, verbal number. I argue that reduplication provides evidence that participant number suppletion is not directly triggered by the argument, and I propose a unified account of participant number where there is a verb-internal number node that reflects number and mediates an agreement relation between the argument and the root. The number node, which marks plural arguments and events, may be valued by the closest c-commanding DP, and will be realized as reduplication or will trigger root suppletion. This is supported cross-linguistically by languages which mark both participant and event number by reduplication and suppletion. I propose that this head allows a stricter locality condition on suppletion where the trigger is always a head in the morphological word (complex X⁰). My analysis bears on current issues of locality and suppletive domains since I argue that the topmost complex X⁰ node forms a morphological domain which contains smaller domains that are privileged in the syntax but restrictive in the morphophonology.
Exploring Merge: A new form of sideward movement
Authors: Takano Yuji 
Published: June 2019

AbstractThis paper explores Merge and proposes a new form of sideward movement (double sideward movement) carried out by a new application of External Merge. Double sideward movement occurs in the following way: given a syntactic object S containing XP and YP, Merge applies to XP and YP, and creates {XP, YP} outside S, thus causing XP and YP to undergo sideward movement at the same time. It is argued that multiple clefts (cleft sentences with multiple phrases in the focus position) in Japanese are derived by double sideward movement of the multiple focus phrases and that this derivation is responsible for certain surprising properties of Japanese multiple clefts, some well known and others newly discovered, including the lack of island effects and the presence and absence of clausemate effects. Other consequences are discussed for the nature of operator movement and scrambling as well as for restrictions on the application of Merge.
ERRATUM - revista Letras de Hoje edição v. 53, n. 3 (2018) - ID 30988
Authors: Da revista Letras de Hoje Equipe Editorial 
Published: June 2019

A Equipe Editorial da revista Letras de Hoje torna publica as seguintes alteração e substituição, na edição v. 53, n. 3 (2018),DOI:http:/dx.doi.org/10.15448/1984-7726.2018.3 , ID 30988, artigo, “Eu e meus alunos-cotistas na escola pública”: racismo, ethos discursivo, discurso midiático e produção de subjetividade.
Irã: políticas islâmicas e mulheres em busca de igualdade
Authors: Hoodfar Homa , Sadr Shadi 
Published: June 2019

No Irã, a fusão de um Estado forte com leis e instituições religiosas após a revolução iraniana de 1979, gerou uma estrutura estatal dual. As instâncias não eleitas exercem ali o controle sobre os órgãos eleitos e, na maioria das vezes, não aceitam o primado da democracia nem tampouco o princípio de igualdade entre os sexos (ou entre muçulmanos e não muçulmanos). A questão central que se coloca aqui é a de saber se um Estado religioso é capaz de se adequar a tais normas. O exame das políticas implementadas mostra que, no caso do Irã e do xiismo, o principal obstáculo deve-se mais às relações não democráticas entre Estado e Sociedade do que à compatibilidade (ou falta de) real ou potencial das tradições e práticas religiosas com os princípios democráticos.
Sprawa następstwa tronu po Bolesławie V Wstydliwym, księciu krakowskim i sandomierskim
Authors: Supernak Karolina 
Published: June 2019

Bolesław Wstydliwy, książę krakowski był bezdzietny, być może w wyniku ślubów czystości, jakie złożył z żoną. W 1265 roku książę Bolesław w czasie swojej choroby adoptował swojego krewnego – Leszka Czarnego – i uczynił go następcą tronu w Krakowie. Drugim tytułem Leszka do tronu była elekcja możnych. W okresie piastowskim w księstwie krakowsko-sandomierskim wybierano księcia zwierzchniego. Pierwszym tak wybranym władcą krakowskim, zwanym princepsem, był Kazimierz Sprawiedliwy, a następnie jego nieletni syn Leszek Biały. Kolejni monarchowie byli również wybierani w drodze elekcji, lecz wybory utrzymywano w dynastii Piastów i były one z reguły jedynie potwierdzeniem elekcji, tak jak w przypadku Leszka Czarnego. Bolesław wybrał Leszka między innymi dlatego, że ten zdecydował się współpracować z nim w czasie wojny między Czechami a Węgrami. Leszek Czarny jako spadkobierca Wstydliwego poślubił Gryfinę, siostrzenicę Kingi. Wydaje się, że możni akceptowali decyzję Bolesława w sprawie następstwa tronu.
The Prevalence of Symptoms of Life-Threatening Events in Infants of the First Year of Life: a Cross-Sectional Population Study
Authors: Korableva Natalya N. , Pershina Ekaterina N. , Gusev Vladimir A. 
Published: June 2019

Background.The prevalence of symptoms of life-threatening events in infants was previously studied using hospital data. However, not all parents in the event of such symptoms seek medical help in the hospital.Objective.Our aim was to identify the prevalence and risk factors of life-threatening events in infants in the first year of life.Methods.In the period from November 2017 to February 2018, we interviewed mothers who have children in their second year of life who are registered at children's outpatient clinics in Syktyvkar. Respondents noted episodes of absent, infrequent or irregular breathing, blanching or cyanosis of the skin, changes in muscle tone (hypo- or hypertonia), changes in the level of responses that occurred in infancy. The prevalence of symptoms of life-threatening events was estimated based on the total number of infants in the first year of life (n = 3088) who lived in Syktyvkar as of January 1, 2018.Results.At least one symptom of life-threatening events in infancy was reported by 43 (4.3%) of the 1001 mothers surveyed. The prevalence of symptoms was 429.5 [95% confidence interval (CI) 321–574] per 10,000 children of the corresponding age. Independent predictors of life-threatening events in children of the first year of life were sudden deaths of relatives under the age of 50 years [odds ratio (OR) 2.4; 95% CI 1.1–5.3], cases of pre-syncope or syncope in relatives (OR 4.4, 95% CI 2.1–9.0), artificial feeding of infants (OR 4.0, 95% CI 1.5–11.2). The sensitivity of the model, which took into account the presence of at least one of the three predictors, was 19% (8/43), specificity — 99% (2/958).Conclusion.The issue of the occurrence of life-threatening events in an infant can impact every 25th family. In every fifth infant, the occurrence of symptoms of life-threatening events can be predicted based on risk factors.
Tyrosine Phosphorylation of CD2AP Affects Stability of the Slit Diaphragm Complex
Authors: Tossidou Irini , Teng Beina , Worthmann Kirstin , Müller-Deile Janina , Jobst-Schwan Tilman , Kardinal Christian , Schroder Patricia , Bolanos-Palmieri Patricia , Haller Hermann , Willerding Jonas , Drost Dana M. , de Jonge Laura , Reubold Thomas , Eschenburg Susanne , Johnson Ruth I. , Schiffer Mario 
Published: June 2019

Significance StatementThe connection between the slit diaphragm and actin network of podocytic foot processes involves complex signaling between slit diaphragm proteins and multiple signaling pathways of the actin machinery. CD2AP, a slit diaphragm–associated scaffolding protein, is considered a “stabilizer” of the complex that connects the slit diaphragm protein nephrin to the cell’s cytoskeleton. In this study, the authors define CD2AP as a phosphorylation target of receptor tyrosine kinases stimulated by VEGF-A in podocytes. They demonstrate that phosphorylation of tyrosine at position Y10 of the SH3-1 domain of CD2AP can change the affinity of CD2AP to nephrin and is indispensable for CD2AP function and slit diaphragm functionalityin vivo. These findings implicate CD2AP phosphorylation as a molecular target in proteinuric kidney diseases.BackgroundCD2-associated protein (CD2AP), a slit diaphragm–associated scaffolding protein involved in survival and regulation of the cytoskeleton in podocytes, is considered a “stabilizer” of the slit diaphragm complex that connects the slit diaphragm protein nephrin to the cytoskeleton of the cell. Tyrosine phosphorylation of slit diaphragm molecules can influence their surface expression, but it is unknown whether tyrosine phosphorylation events of CD2AP are also physiologically relevant to slit diaphragm stability.MethodsWe used isoelectric focusing, western blot analysis, and immunofluorescence to investigate phosphorylation of CD2AP, and phospho-CD2AP antibodies and site-directed mutagenesis to define the specific phosphorylated tyrosine residues. We used cross-species rescue experiments in Cd2apKDzebrafish and inDrosophila cindrRNAimutants to define the physiologic relevance of CD2AP phosphorylation of the tyrosine residues.ResultsWe found that VEGF-A stimulation can induce a tyrosine phosphorylation response in CD2AP in podocytes, and that these phosphorylation events have an important effect on slit diaphragm protein localization and functionalityin vivo. We demonstrated that tyrosine in position Y10 of the SH3–1 domain of CD2AP is indispensable for CD2AP functionin vivo. We found that the binding affinity of nephrin to CD2AP is significantly enhanced in the absence of Y10; however, unexpectedly, this increased affinity leads not to stabilization but to functional impairment of the glomerular filtration barrier.ConclusionsOur findings provide insight into CD2AP and its phosphorylation in the context of slit diaphragm functionality, and indicate a fine-tuned affinity balance of CD2AP and nephrin that is influenced by receptor tyrosine kinase stimulation.
Böbrek Naklinde Hücresel Tedavilerin Kullanımı
Authors: ŞENOL Özgür , KAYA Egemen , KARAKUŞ Volkan 
Published: June 2019

Günümüzde,
tıp, cerrahi alanında görülen gelişmeler ve teknolojik olarak geliştirilen
modern ilaçların kullanımıyla beraber, geçtiğimiz yüzyılda böbrek hastalıkları
da dahil olmak üzere, ölümcül olan birçok hastalık artık tedavi edilebilir
konuma gelmiştir. Böbrek nakli, elde edilen başarılar ile beraber, hem böbrek hastalıkları için bir tedavi
seçeneği haline gelmiş ve böbrek nakil oranları artış göstermiş, hem de
beklenen yaşam süresi uzamıştır. Böbrek nakli yapılan hastaların cerrahi
sonrası tedavi süreçlerinde immünsüpresif ilaçlar kullanılmaktadır. Yeni
geliştirilmeye çalışılan tedavi seçenekleri ile hem böbrek naklinde elde edilen
başarı oranı arttırılmaya çalışılmakta hem de immünsüpresif ilaçların
kullanımının yol açtığı yan etkilerin giderilmesi amaçlanmaktadır. Hücresel
tedaviler de böbrek naklinde kullanılması için üzerinde çalışılan tedavi
seçeneklerinden bir tanesidir. Regülatör T hücreler, regülatör B hücreler, regülatör
makrofajlar, dendritik hücreler, mezenkimal kök hücreler, organ nakillerinde
kullanılması için araştırma ve deneme yapılan hücre kaynaklarındandır. Deney
hayvanlarında nakil modellerinde yapılan çalışmalarda, hücre tedavileri ile
başarılı sonuçlar alındığı gösterilmiştir. Bu derlemede böbrek naklinde
kullanılan ve de kullanılmaya aday olan hücre tedavileri tartışılmıştır.
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE TGT (TEAM GAMES TOURNAMENT) TERHADAP MOTIVASI BELAJAR DAN KEMAMPUAN MOTORIK SISWA ASRAMA KELAS VII
Authors: Sonjaya Azhar Ramadhana 
Published: June 2019

ABSTRAK Tujuan dari penelitian ini adalah mengidentifikasi pengaruh model pembelajaran kooperatif tipe TGT dan model pembelajaran konvensional terhadap motivasi belajar dan kemampuan motorik siswa, Metode yang digunakan adalah pretest-posttest control group design dengan menggunakan cara random assignment. Populasi penelitian ini adalah siswa asrama kelas VII Pondok Pesantren PERSIS Tarogong Kabupaten Garut berjumlah 30 siswa dengan menggunakan teknik total sampling dan waktu pelaksanaan penelitian selama 12 kali pertemuan, setiap minggu dilakukan penelitian sebanyak 3 hari. Hasil dari uji penelitian ini menggunakan uji Manova (Multivariate Analisis of Varians) dengan program SPSS seri 16. Berdasarkan hasil uji hipotesis rata-rata motivasi belajar pendidikan jasmani yang diberikan model pembelajaran kooperatif tipe TGT sebesar 14,875 lebih besar dibandingkan rata-rata motivasi belajar siswa yang diberikan model pembelajaran secara konvensional yakni sebesar 5,25. Demikian juga untuk rata-rata kemampuan motorik siswa yang diberikan model pembelajaran kooperatif tipe TGT sebesar 6,681 lebih besar dibandingkan rata-rata kemampuan motorik siswa yang diberikan model pembelajaran konvensional yakni sebesar 4,648. Maka model pembelajarankooperatif tipe TGT lebih baik dibandingkan model pembelajaran konvensional terhadap motivasi belajar dan kemampuan motorik siswa asrama kelas VII di Pondok Pesantren PERSIS Tarogong Kabupaten Garut pada pelajaran pendidikan jasmani.