bluuebunny/crossref_metadata_2025_split huggingface dataset:
FM2-3 Slave to the rhythm: seasonal differences in non-motor symptoms in parkinson’s
Authors: Wamelen DV , Podlewska A , Leta V , Rizos A , Chaudhuri K 
Published: February 2019

ObjectivesTo determine the effect of the change of season on non-motor symptoms in Parkinson’s disease (PD).DesignCross-sectional retrospective study.Subjects364 consecutive Parkinson’s patients in the London area taking part in the Non-motor Longitudinal International Study (NILS) study at King’s College Hospital London between November 2011 and April 2018.MethodsParticipants were divided into three groups based on their assessment date, using a simplified ecological seasonal model:November until February;March until 15 June;16 June until October.The primary outcome was a seasonal difference in non-motor symptom scale (NMSS) total scores and the secondary outcomes were NMSS subscores. Outcomes were adjusted for multiple testing using formal Bonferroni correction.Results102 patients were allocated to group 1, 105 patients to group 2 and 157 patients to group 3. Seasonal differences were present in NMSS total scores (p=0.042), especially between groups 1 and 3 (p=0.037). Differences were also present for NMSS domain 1 (cardiovascular and falls; p=0.004), 2 (sleep and fatigue; p=0.049), 4 (hallucinations; p=0.003) and 9 (miscellaneous; p=0.031). Within domain 9 there was only a significant difference for question 28 (smell; p=0.008).ConclusionsThese results indicate that non-motor symptoms in Parkinson’s fluctuate throughout the year with lowest scores in the summer months and highest in the winter months. These variations need to be taken into account to avoid inappropriate changes in medication regimes.
WP1-5 Surgical management of spinal meningiomas and appraisal of possible association with oestrogen receptor positive breast carcinoma
Authors: Wang D , Sadek AR , Nader-Sepahi A 
Published: February 2019

ObjectivesEvaluation of the presentation, demographics, pathology and outcomes associated with surgical management of spinal meningiomas and review of an association with a history of preceding breast carcinoma.DesignA retrospective single-centre case series of surgically managed meningiomas over a 4 year period.Subjects184 cases of surgically managed intradural lesions from 2014 to 2018.Results48 patients were identified as having a spinal meningioma [26% of all spinal tumours]. 42 [88%] were female with a cumulative mean age of 69 years [SD ±10]. Most lesions were located in the thoracic spine [n=41]. The cohort had a Charlson comorbidity index of 3. Weakness [median MRC grade 3], neuropathic pain [mean NPS of 26/100] and problems with gait [median mJOA score of 2] were the commonest presenting symptoms. Post-operatively improvements in MRC, NPS, mJOA and SF36 scores were observed. 16% [n=7] of cases had a preceding history of oestrogen-receptor positive breast carcinoma, with a mean interval time between diagnoses of 8.1 years [SD ±5.1]. Risk analysis using baseline data from national cancer registries demonstrates that the likelihood of both diagnoses to be 4.9%, this is considerably lower than the observed 16% (p=0.01).ConclusionsAnalysis of our cohort has demonstrated an association between a preceding diagnosis of oestrogen-receptor positive breast carcinoma and spinal meningiomas that cannot be explained by chance alone.
FP2-1 Prognostic value of leucocytosis in paediatric traumatic brain injury
Authors: Mukherjee S , Sivakumar G , Goodden J , Tyagi A , Chumas P 
Published: February 2019

ObjectivesWe assessed leucocytosis and evaluated its prognostic value in isolated paediatric traumatic brain injury (TBI).DesignRetrospective analysis.Subjects106 consecutive paediatric patients with isolated TBI admitted between June 2008 and June 2016.MethodsInitial blood leucocyte count (WCC), Glasgow Coma Score (GCS), computed tomographic (CT) findings, duration of hospital stay, and Paediatric Cerebral Performance Category Scale (PCPCS) scores were analysed.ResultsMean age was 4.2 years. For patients with GCS 3–8, 9–13 and 14–15, WCC was 20, 15.9 and 10.7 × 109/L respectively. Differences in WCC were significant between the different GCS groups (p<0.01). Length of hospital stay, extent of midline shift on CT and poor 6 month PCPCS rating were each significantly correlated with WCC (p<0.05). Multivariate regression analysis revealed a cut-off WCC of 16.1 × 109/L, above which GCS, CT findings, length of hospital stay and PCPCS were less favourable. Application of the International Mission on Prognosis and Analysis of randomized Controlled Trials in TBI (IMPACT) adult TBI prediction model to our paediatric cohort, using area under the operating curve (AUROC) and coefficient analyses, demonstrated increased accuracy with incorporation of WCC as a risk factor.ConclusionsHigh initial leucocytosis (>16.1×109/L) is predictive for poor GCS, severe CT findings, lengthy hospital stay and poor PCPCS in isolated paediatric TBI. Incorporating WCC into TBI prediction models may increase the accuracy of prognostication.
FP2-3 Ten years of paediatric neuro-oncology surgery: quantifying and predicting complications after surgery for intracranial tumour excision
Authors: Foster MT , Grayston R , Hennigan D , Harishchandra LS , Tonder LV , Millward CP , Pettorini B , Sinha A , Parks C , Burn S , Pizer B , Mallucci C 
Published: February 2019

ObjectivesTo measure complications of paediatric neurooncology surgery using the Clavien Dindo grading scale, and identify predictors of surgical morbidity.DesignRetrospective review of prospectively collected data.SubjectsAll paediatric patients treated with craniotomy for excision of intracranial tumour between 2008 and 2017 in a single tertiary paediatric neurosurgery centre.MethodsDemographics, surgical details and perioperative complications were prospectively recorded between 0 and 30 days post operatively. These were retrospectively graded using the CD scale. Data analysis was done in R using logistic regression. Significance was defined as p<0.05ResultsBetween 3/1/2008 and 21/12/2017 there were 322 operations, on 254 patients (142 Male). Median age at surgery was 9 years (IQR 4–13 years). 48% were without complication on the CD scale. Maximum CD grade complication for each procedure was 1 in 11%, 2 in 19%, 3A in 2%, 3B in 14%, and 4 in 0.6% of operations. 30 day mortality was 0.9%. CD grade of 3B or over was associated with infratentorial tumours (OR 2.24; CI 1.10–4.68; p=0.004) and WHO grade III tumours (OR 4.12; CI 1.56–10.86; p=0.028).ConclusionsComplications in paediatric neurooncology surgery are common overall, but our results are favourable in comparison to the literature. The CD scale has limitations in neurosurgery but gives insight into the health economic impact of complications. Infratentorial tumours, and WHO grade III tumours were associated with increased morbidity.
FP2-4 Paediatric posterior fossa tumour resection rates in a small volume centre: the past decade’s experience
Authors: Bhatt H , Bhatti MI , Patel C , Leach P 
Published: February 2019

ObjectivesResection rates for paediatric brain tumours correlate with outcome. At the 2018 BPNG meeting a commitment to prospectively collect resection data was made. Here we review our posterior fossa resection rates for the last decade.DesignRetrospective observational cohort study of paediatric posterior fossa astrocytomas, medulloblastomas and ependymomas from 2008–2018. Primary outcome measure was extent of resection on post-op MRI, with secondary outcomes including post-op complications and need for temporary/permanent CSF diversion.Subjects57 patients had 62 operations for: 26 astrocytomas, 28 medulloblastomas and 8 ependymomas. Ages ranged from 7 months-16 years, with a median of 9, 7 and 6 years, respectively, and an even male: female split. Follow-up ranged from 2 months to >10 years.MethodsPatients were identified from a prospectively collected paediatric neuro-oncology database, with clinical notes and peri-operative imaging used for analysis. Our results were compared to the published literature.ResultsComplete resection (CR) rates after 1 st surgery for patients with astrocytomas, medulloblastomas and ependymomas were 77%, 79% and 63%, respectively. 5/57 patients had a 2nd operation later, 3 of whom had primary CR followed by recurrence.ConclusionsOur resection rates, complications and need for CSF diversion are comparable to the literature. Factors enabling this in a low-volume centre may include a robust paediatric neuro-oncology framework, fellowship-trained subspecialty surgeons and joint operating.
FP2-7 Is whole spine imaging necessary in the evaluation of children with lumbosacral lipoma?
Authors: Horsfall HL , Simcock C , D’Arco F , Thompson D 
Published: February 2019

ObjectivesPaediatric lumbosacral lipomas are commonly assessed by whole spine MRI, which is costly, time consuming and reduces imaging detail at the region of interest. This study evaluates the utility of whole spine vs local spine MRI in paediatric lumbosacral lipoma (LSL).DesignSingle centre, retrospective, radiological review.Subjects119 patients (77F:46M) aged 0.8 years (0.2–3.9) (median ±IQR) with complex LSL who had whole spine MRI between 2001–2017.MethodsLumbosacral lipomas were identified from a prospectively collected database. Cases where whole spine MRI was available were included. Type of lipoma and any associated spinal anomalies were recorded.Results347 patients had LSL, of which 119 (34%) patients had whole spine MRI. 3% were excluded due diagnosis of fatty filum terminale. 13% scans were unavailable. 119 patients were studied: 77F:46M aged 0.8 years at scan. Type of LML: transitional 36%; caudal 18%; dorsal 19%; unclassified 26%. Additional imaging abnormalities included: syrinx 18%; Chiari 1%; dermal sinus tract 13%; vertebral segmentation 13%; other 2%. None were associated with clinical symptoms nor required surgical treatment. Investigating the cost-benefit analysis of modality, lumbar spine required less MR time and cost less (40 vs 20 mins; £228.69 vs £282.39).ConclusionsThe low incidence of clinically relevant secondary lesions suggests that lumbosacral MRI only is necessary in the assessment of LSL. Imaging quality of the ROI can be optimised and MRI time and costs reduced.
P4 Spinal cord haemangioblastomas: surgical management and clinical outcome
Authors: Pitsika M , Nissen J , Jenkins A , Mitchell P 
Published: February 2019

ObjectivesSpinal haemangioblastomas are rare tumours that can be either sporadic or as part of the CNS expression of Von Hippel Lindau syndrome (VHL). The aim of this study was to identify the characteristics of the haemangioblastomas both in sporadic and in VHL cases and to assess the outcome of the surgical management.MethodsWe retrospectively reviewed all spinal haemangioblastomas that were operated between 2004 and 2017 including clinical letters, MRIs and pathology reports.ResultsA total of 14 patients underwent excision of a spinal haemangioblastoma. Average follow up time was 50 months (range 4–164 months). The location was: medulla n=3, cervical region n=4, thoracic region n=5 and conus n=2. Six patients had VHL (42%) and from those n=5 had more than one lesion. A syrinx was present in n=9 cases (VHL n=6, multiple lesions n=5) and 2 had a syringoperitoneal shunt inserted followed by excision of the haemangioblastoma. In all but one case a total excision was achieved and the syrinx disappeared or improved in 6 cases. A clinical improvement was seen in n=10 patients, in n=2 a deterioration was seen post-operatively and in n=2 new symptoms developed during their follow up from the other lesions. None of the haemangioblastomas that were removed recurred.ConclusionsTotal excision of spinal haemangioblastomas offers a good outcome with possible cure in cases of a single lesion. Patients with VHL present more commonly with multiple lesions and large syrinxes which pose a challenge to the surgical management.
P6 The use of 5-ALA fluorescence in excision of supratentorial endodermal cyst
Authors: Raslan A , Acharya S , Lavrador JP , Vergani F , Bhangoo R , Ashkan K 
Published: February 2019

ObjectivesThe first documented use of 5-ALA in the excision of an intraparenchymal endodermal cyst.DesignCase review.Subjects52 year old female presented with headaches, progressive right sided hemiparesis and anomic aphasia. She had a large cystic frontal lesion, adjacent of the frontal horn of the lateral ventricles cyst which did not show any nodular or solid component, and did not enhance with gadolinium.MethodsCase report and review of the literature.Results5-ALA assisted, image guided fenestration of the cystic lesion and insertion of a ventricular catheter connected to an Ommaya reservoir was performed. The cyst wall was observed under the microscope and it fluoresced with 5-ALA. Multiple biopsies were obtained from this tissue, which confirmed diagnosis of endodermal cyst. The patient had improvement in clinical symptoms and size of the cyst radiologically in both the immediate post-operative period and the 6 months follow up.ConclusionsPrevious reports described the use of 5-ALA to identify tumour cells within the solid component of cystic haemangioblastomas as well as in cystic ependymomas where the cystic component does not fluoresce. In our patient, the homogeneous fluorescence of the wall suggested that this was indeed a different entity from a haemangioblastoma or an ependymoma because of the different pattern of fluorescence observed. 5-ALA-assisted resection of cystic lesions should be considered when a tumoral origin is uncertain.
P20 Parental understanding of concussion in youth rugby is significantly improved by viewing the RFU concussion education video
Authors: Samuel T , Aquilina K , Dawes W 
Published: February 2019

ObjectivesTo investigate the current understanding parents have of concussion in their rugby-playing children aged 9–17.DesignCross-sectional studySubjects86 parents from four clubs completed an online questionnaireMethodsAreas covered (1) Parental experience of concussion (2) Rate of viewing of the RFU concussion educational video (RFUCEV), (3) Identification of symptoms of concussion (4) Understanding of the risk of concussion. Each participant was given a composite score, out of 19, based on their performance in symptom identification and true/false questions. Independent-sample two-tailed t-tests were conducted to analyse scores, primarily controlling for viewing of the RFUCEVResultsThere was a significant difference in the scores between the group that had viewed the RFUCEV (n=32, M=14.75, SD=2.55) and those who had not (n=54, M=13.05, SD=2.87); t(84)=2.75, p=0.00721. Additionally, over 25% of parents reported that their child had suffered a concussion, and this was also found to significantly improve the awareness score (p=0.04678)ConclusionsStatistically significant improvement in composite scores after viewing the RFUCEV makes it reasonable to require compulsory parental education prior to signing up a child to play rugby. This would build on the protocol changes made by the RFU in 2014 and further progress the safety of the sport. We suggest the video be improved to emphasise the areas highlighted as inadequately understood, including the increased risk of concussion in under-18s compared to adults.
P22 Phenytoin versus levetiracetam for post traumatic brain injury seizure prophylaxis; a retrospective study at a UK major trauma centre
Authors: Harris L , Hateley S , Seemungal B 
Published: February 2019

Objectives12% of patients with severe Traumatic brain injury (TBI) suffer from seizures. Evidence suggests that the use of an antiepileptic drug (AED) is beneficial in preventing early post TBI seizures. To date, no specific NICE guidelines exist on the choice of post TBI seizure prophylaxis. This study aims to identify the trend in AED usage, the impact on length of stay and to compare the tolerability of phenytoin and levetiracetam.DesignRetrospective observational study.Subjects201 patients.MethodsAll patients admitted to a Major Trauma Unit following a head injury treated with levetiracetam or phenytoin for seizure prophylaxis were included in the study. Data was collected between October 2013 – September 2014 and November 2016 – October 2017. Patient demographics, Glasgow Coma Score (GCS) on admission, length of treatment, AED toxicity, length of stay, complications, surgical input and length of ITU stay were recorded.Results85.6% of patients were treated with phenytoin in 2013–2014% and 82.5% were treated with levetiracetam in 2016–2017. The average length of stay for phenytoin was 23.2 days and 13.9 days for levetiracetam. Subgroup analysis was performed on patients with an admission GCS of 14–15. Length of stay for phenytoin was 14.9 days (SD −11.87) and levetiracetam 9.4 days (SD 10.588) (p=0.07). 24% of patients on phenytoin and 14% on levetiracetam suffered from dizziness.ConclusionsThis suggests that levetiracetam is tolerated better with fewer side effects. We recommend its use in clinical practice.
Running to breaking point? The relationship between 1.5-mile run time and injury risk in female recruits during British Army basic training
Authors: Heller Rosalie , Stammers H 
Published: February 2019

IntroductionThe 1.5-mile best-effort run is used in the British Army to assess the fitness of all recruits and trained service personnel by means of the physical fitness assessment (PFA). The 1.5-mile run is a basic measure of fitness and slower times have been associated with an increased risk of musculoskeletal injury (MSkI), particularly during this early stage of training. The aim of this study was to establish whether 1.5-mile run times were associated with subsequent MSkIs among female recruits during their 14-week basic training.MethodRetrospective data were analysed from female recruits who had undertaken basic military training between June 2016 and October 2017. This included retrieving the results of their week 1 PFA; recording the type, cause and week of MSkI if they had sustained one; and noting down their outcome from basic training. Run times were statistically analysed in relation to MSkI occurrence of 227 female recruits using binomial logistic regression with an accepted alpha level of p value <0.05.Results1.5-mile run time predicted risk of MSkI (χ2(1)=12.91, p<0.0005) in female recruits. The mean run time for injury-free recruits was faster than for injured recruits (12 min 13 s compared with 12 min 43 s). Every 10 s increase in run time was associated with an 8.3% increase in risk of injury.ConclusionSlower 1.5-mile best-effort run time, as a surrogate of aerobic fitness, is associated with increased risk of MSkI in female recruits during basic training.
Unhealthy dietary patterns are related to low ceruloplasmin in female nurses
Authors: Abashzadeh Karolin , Abshirini M , Siassi F , Qorbani M , Koohdani F , Farasati N , Sotoudeh G 
Published: February 2019

Background and objectiveFew studies have examined the relationship between dietary patterns and antioxidant status. We aimed to explore the association between major dietary patterns and oxidative stress biomarkers including serum protein carbonyl (PC), ceruloplasmin and total antioxidant capacity (TAC).MethodIn this cross-sectional study, we randomly selected 320 female nurses aged 20–45 years. General information of participants was collected by trained interviewers. Their weight and height were measured and dietary intakes were determined by the 147-food-item semiquantitative food frequency questionnaire. Dietary patterns were derived by principal component analysis of yielding 25 food groups. In this study, 90 subjects were randomly selected from all participants with serum levels of PC, ceruloplasmin and TAC measured further. To determine the association between dietary patterns’ score and oxidative stress biomarkers, multiple linear regression analysis was conducted.ResultsThree dietary patterns were derived: healthy, unhealthy and traditional. After adjusting for several confounding factors, the unhealthy dietary pattern was inversely related to the serum concentration of ceruloplasmin and PC (p<0.05). The relationship between other dietary patterns and antioxidant biomarkers was not significant.ConclusionsAccording to the results of this study, unhealthy dietary patterns may have an adverse effect on serum ceruloplasmin.
Institutional and provider variations for mechanical thrombectomy in the treatment of acute ischemic stroke: a survey analysis
Authors: Mehta Tapan , Male Shailesh , Quinn Coridon , Kallmes David F , Siddiqui Adnan H , Turk Aquilla , Grande Andrew Walker , Tummala Ramachandra Prasad , Jagadeesan Bharathi Dasan 
Published: February 2019

IntroductionStent retriever combined with aspiration, or the ‘Solumbra technique’, has recently emerged as one of the popular methods of mechanical thrombectomy (MT). However, the variations in understanding and implementation of the Solumbra technique have not been reported.MethodsAn 18 part anonymous survey questionnaire was designed to extract information regarding technical variations of MT with a focus on the Solumbra technique. The survey link was posted on the Society of Neurointerventional Surgery (SNIS) website in ‘SNIS connect’.Results80 responses were obtained over 4 weeks that were included in the final analysis. Direct aspiration without a balloon guide catheter (BGC) was the most favored technique among respondents (41.12%) followed by the Solumbra technique without a BGC (32.4%). Among those using the Solumbra technique, 77.6% reported that they wait between 2 and 5 min to allow clot engagement, 55.2% always remove the microcatheter before aspiration, and 69.1% commence aspiration through the intermediate catheter only when retrieving the stent retriever. Operators who infrequently used or did not use BGCs reported a higher incidence of >80% Thrombolysis in Cerebral Infarction 2b/3 annual recanalization rates (OR 8.85, 95% CI 2.03 to 38.55, P=0.004) compared with those who consistently used BGCs.ConclusionOur study documents the variations in MT techniques, and more specifically, attempts to quantify variations in the Solumbra technique. The impact of these variations on recanalization rates and eventually patient outcomes are unclear, especially given the self-reported outcomes contained in this study.