bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipid droplet–membrane contact sites – from protein binding to function
Authors: Thiam Abdou Rachid , Dugail Isabelle 
Published: June 2019

ABSTRACT
In the general context of an increasing prevalence of obesity-associated diseases, which follows changing paradigms in food consumption and worldwide use of industry-transformed foodstuffs, much attention has been given to the consequences of excessive fattening on health. Highly related to this clinical problem, studies at the cellular and molecular level are focused on the fundamental mechanism of lipid handling in dedicated lipid droplet (LD) organelles. This Review briefly summarizes how views on LD functions have evolved from those of a specialized intracellular compartment dedicated to lipid storage to exerting a more generalized role in the stress response. We focus on the current understanding of how proteins bind to LDs and determine their function, and on the new paradigms that have emerged from the discoveries of the multiple contact sites formed by LDs. We argue that elucidating the important roles of LD tethering to other cellular organelles allows for a better understanding of LD diversity and dynamics.
Improving the practice of inferior vena cava filter retrieval: a quality improvement intervention and audit outcomes
Authors: Peress Luisa , Kamil Sally , Fernandez Maria , Lastimosa Rowena , Jaffer Ounali , Patel Snehal , Akhtar Mohammed Rashid , Kyaw Tun Jimmy 
Published: June 2019

Objective:
To review inferior vena cava (IVC) filter retrieval practice at our institution, the Royal London Hospital, and measure changes following a quality improvement intervention. IVC filters are a preventive treatment for pulmonary embolism when anticoagulation is ineffective/contraindicated. Unless permanent filtration is required, all filters should undergo attempted retrieval within manufacturer’s recommendations with a success rate of ≥80 %.

Methods:
Retrospective audit of filters inserted between 2011 and 2014, followed by a quality improvement intervention and a second audit between 2015 and 2017. Clinical–radiological data were analysed using the Picture Archiving and Communication System and electronic patient records.

Results:
During the first audit, filter retrieval was attempted in 92% of cases, of which 82% underwent the procedure within manufacturer's recommendations and 86% were successful. During the second audit, an improvement across indicators was seen. Retrieval increased by 3% and was attempted in 95% of cases (92% of which were within manufacturer’s guidelines). Rate of retrievals within manufacturer’s guidelines increased by 10%. Filter retrieval success rate increased by 11% - to 97%.

Conclusions:
IVC filter retrieval practice at a single institution can be improved by implementing a simple audit intervention.

Advances in knowledge:
Filter retrieval practice has clinical and medicolegal implications. A simple quality intervention can substantially improve overall practice.
Competing risk survival analysis of time to in-hospital death or discharge in a large urban neonatal unit in Kenya
Authors: Aluvaala Jalemba , Collins Gary S. , Maina Beth , Mutinda Catherine , Wayiego Mary , Berkley James A. , English Mike 
Published: June 2019

Background: Clinical outcomes data are a crucial component of efforts to improve health systems globally. Strengthening of these health systems is essential if the Sustainable Development Goals (SDG) are to be achieved. Target 3.2 of SDG Goal 3 is to end preventable deaths and reduce neonatal mortality to 12 per 1,000 or lower by 2030. There is a paucity of data on neonatal in-hospital mortality in Kenya that is poorly captured in the existing health information system. Better measurement of neonatal mortality in facilities may help promote improvements in the quality of health care that will be important to achieving SDG 3 in countries such as Kenya. Methods: This was a cohort study using routinely collected data from a large urban neonatal unit in Nairobi, Kenya. All the patients admitted to the unit between April 2014 to December 2015 were included. Clinical characteristics are summarised descriptively, while the competing risk method was used to estimate the probability of in-hospital mortality considering discharge alive as the competing risk. Results: A total of 9,115 patients were included. Most were males (966/9115, 55%) and the majority (6287/9115, 69%) had normal birthweight (2.5 to 4 kg). Median length of stay was 2 days (range, 0 to 98 days) while crude mortality was 9.2% (839/9115). The probability of in-hospital death was higher than discharge alive for birthweight less than 1.5 kg with the transition to higher probability of discharge alive observed after the first week in birthweight 1.5 to <2 kg. Conclusions: These prognostic data may inform decision making, e.g. in the organisation of neonatal in-patient service delivery to improve the quality of care. More of such data are therefore required from neonatal units in Kenya and other low resources settings especially as more advanced neonatal care is scaled up.
Solvent Effect on Fluorescence Quenching of 7, 8 Benzo‑4‑azido Methyl Coumarin by Aniline
Authors: Melavanki R M , Patil N R , Nagaraja D , Patil H D , Kadadevarmath J S , Kusanur R A 
Published: June 2019

Fluorescence quenching of biologically active studies of 7, 8 benzo-4-azidomethyl coumarin (7BAMC) by aniline in four different organic solvents namely benzene, dioxane, tetrahydrofuran and acetonitrile has been carried out at room temperature with a view to understand the quenching mechanisms. The Stern–Volmer (S-V) plot has been found to be non-linear with a positive deviation for all the solvents studied. In order to interpret these results we have invoked the ground state complex formation and sphere of action static quenching models. Using these models various quenching rate parameters have been determined. The magnitudes of these parameters suggest that sphere of action static quenching model agrees well with the experimental results. Hence the positive deviation is attributed to the static and dynamic quenching. Further, with the use of Finite Sink approximation model, it was possible to check these bimolecular reactions as diffusion-limited and to estimate independently distance parameter R’ and mutual diffusion coefficient D. Finally an effort has been made to correlate the values of R’ and D with the values of the encounter distance R and the mutual coefficient D determined using the Edward’s empirical relation and Stokes – Einstein relation.
Diversity of Phytoplankton and Pollution Tolerant Species of Navule Pond, Shivamogga, Karnataka
Authors: Begum Nafeesa , Ashashree H M , Sayeswara H A 
Published: June 2019

The present study deals with phytoplankton population of Navule pond in Shivamogga during September 2014 to August 2015. Blue-greens constituted the major group (41.75%) followed by Chlorococcalas (36.68%), Diatoms (13.36%), euglenoids (7.35%) and Desmids (0.86%). The phytoplankton community was composed of 11 species of Blue-greens, 20 species of Chlorococcales, 18 species of Diatoms, 11 species of Euglenoids and 08 species of Desmids. Each group of phytoplankton showed different peak periods, the summer season produces relatively more phytoplankton than rainy and winter season. The variations in physico-chemical parameters are responsible for the fluctuation of quantity of phytoplankton. The dominant genera recorded on the pond were Anabaenopsis sp., Ocillatoria sp., Euglena sp., and Phacus. Some of the pollution tolerant species identified during the present study are Scenedesmusquadricauda, Coelastrum sp., Tetraedonmuticum, Ocillatoria sp., Phormidium sp., Microcystis sp., Anabaena sp., Navicula sp., Synedra ulna, Cyclotella sp., and Pinnularia sp. In the present study Microcystisaeroginosa was recorded indicates the civic pollution.
Evaluation of Scipy.ode Integrators in Solving the Lane-Emden Equation for Polytropes as a Boundary Value Problem with a Fitting Method
Authors: Anandaram M N 
Published: June 2019

The use of Scipy integrators like dopri5 and others in accurately solving the Lane-Emden equation of a polytrope as a two-point BVP with fitting is investigated by comparing the Emden radius with the extended precision reference value obtained by Boyd's Chebyshev spectral method. It is found that both dopri5 and dop853 integrators provide acceptable accuracy upto 14 decimal digits.
Monitoring of Pesticide Residues in Commonly Used Fruits and Vegetables in Bengaluru
Authors: Sunaja Devi K R , Leethya Mary 
Published: June 2019

Gas chromatography-mass spectrometry (GC-MS) and Liquid chromatography mass spectrometry (LC-MS) were used to evaluate the level of different pesticides in some commonly used fruits in Bengaluru region of Karnataka. Although most fruits and vegetable samples analyzed were found to be contaminated with pesticide residues, they were under maximum residue limit (MRL) after the salted water wash. Samples with residues above MRL may pose health hazards to the consumers. It may be due to lack of awareness of the farmers about the application dose, method of application and withholding period. The findings of this study provide important data about contamination of pesticide residue in some fruits and vegetables sold in Bengaluru.
Some Numerical Examples on the Stability of Fractional Linear Dynamical Systems
Authors: Priyadharsini S 
Published: June 2019

The concept of stability of a class of fractional-order linear system is considered in this paper. Existing sufficient conditions are assumed to guarantee the stability of linear models with the Caputo fractional derivatives. The results have been developed by using the concept of Laplace transform, and approximations of Mittag-Leffler. Furthermore, results concerning asymptotical stability of linear fractional-order models are also achieved. The proposed method is based upon Eigen values and the characteristic polynomials. Numerical illustrations are specified to exhibit effectiveness of the proposed method.
Colchicine did not affect the viability of induced 2n pollen in <i>Populus tomentosa</i>
Authors: Liu Yan , Zhang Yuan , Zhou Qing , Wu Jian , Zhang Pingdong 
Published: June 2019

Colchicine is widely used as a mutagen to induce production of diploid gametes in plants. However, whether colchicine affects induced pollen viability remains unclear. To clarify whether colchicine affected the viability of induced pollen, we induced production of diploid pollen by colchicine, followed by pollen germination and crossing induced pollen with normal gametes to produce triploid in CarriÃ¨re. The results showed that the predominant meiotic stages and the number of colchicine injections had significant effects on the occurrence rates of induced 2n pollen. When the colchicine injection was given at diakinesis, a significant decrease in the pollen production per bud was observed (â<â0.001). The morphology of the colchicine-induced 2n pollen was similar to that of the natural 2n pollen in its ectexine structure. The pollen germination experiments revealed that there was also no significant difference in germination rates between the induced diploid pollen and natural 2n pollen grains, and 68 triploids were created by crossing colchicine-induced pollen. Our findings revealed that colchicine injection could induce to produce 2n pollen and will not lead to dysfunction of induced diploid pollen.in vitroPopulus tomentosapP. tomentosa
Possible timing for anticoagulation therapy initiation in ischemic stroke patients with atrial fibrillation: further analysis of the hemorrhagic transformation index
Authors: Kalinin M. N. , Khasanova D. R. , Ibatullin M. M. 
Published: June 2019

Objective: to assess the risk of hemorrhagic transformation (HT), by taking into account an appropriate scale (the hemorrhagic transformation index (HTI)) to clarify the possible timing of anticoagulant therapy (AT) initiation in patients with atrial fibrillation (AF) and ischemic stroke (IS) in the middle cerebral artery (MCA) bed.Patients and methods. The admission data of 304 consecutively selected patients (111 men and 193 women aged 32 to 94 years (mean age, 72.7 years) with any form of AF and IS in the MCA basin were analyzed. The end point of the study was any HT according to brain computed tomography findings in the first 2 weeks after the development of IS. The HTI scores were divided into categories based on their predicted HT probabilities, thus yielding four models. Their comparison with the standard (the Diener rule) and the choice of the most appropriate model were done using the binary logistic regression and appropriate analysis (receiver operating characteristic, ROC). The final HTI model and the Diener rule were further used in the Royston–Parmar survival analysis to predict the risk of HT by days after the onset of IS. This was used to plot hazard function and survival, as well as the number of patients to be treated (number needed to treat, NNT) and the number of patients who can be harmed (number needed to harm, NNH). Possible periods for AT initiation were determined by the NNT and NNH plots.Results and discussion. All the HTI models under study were superior to the Diener's rule in the accuracy of HT prediction. However, the HTI model with 0–1, 2–3, 4–5, 6–8 score arrangements was found to be the best one, as shown by the results of tests; it could additionally identify patients at very high (>0.8) risk for HT and somewhat better differentiate patients at low (0.05–0.1) risk. A survival analysis showed that the hazard function peaked on 1 and 3 days after the onset of IS. There was a progressive NNT drop in patients with a HTI score of 0–1 on 1 to 3 days; their curves reached a plateau on day 4. In patients with a HTI score of 2–3, NNT declined on days 1 to 4, with a plateau on day 5. In those with a HTI score of 4–5, NNH was minimal within the first 3 days following the onset of IS, and then there was a significant NNH rise until the end of the second week. In patients with a HTI score of 6–8, NNH remained very low throughout the follow-up period with a significant increase on days 4 to 9, with a subsequent exit to the plateau.Conclusion. The greatest risk of HT is observed on 1 and 3 days after the onset of IS. AT is recommended to patients with a HTI score of 0–1 on day 4 after the onset of IS, to those with a HTI score of 2–3 on day 5, and to those with a HTI score of 4–5 following 2 weeks. AT may be initiated in patients at very high risk for HT (a HTI score of 6–8) on 9 days, provided that HT is absent.
Comparative study of pharmacological correction strategies for moderate cognitive impairment in hypertensive patients
Authors: Vorobyeva O. V. , Sizova Zh. M. , Bogatyreva L. M. 
Published: June 2019

Objective: to investigate the prevalence of cognitive impairment (CI) and possibilities of its pharmacological correction in hypertensive patients, by comparatively evaluating the efficiency of different treatment options: antihypertensive therapy and its combinations with vasoactive drugs and the dopamine receptor agonist piribedil.Patients and methods. At the first stage of the investigation, the prevalence of CI was assessed in a continuous sample of hypertensive patients (n=350). The second stage included a naturalistic comparative study of the efficiency of various therapeutic strategies for moderate CI (MCI) in patients with Stage 1–2 hypertension (n=91). This investigation lasted 48 weeks and consisted of a 24-week treatment period and a 24-weeks follow-up period.Results and discussion. CI was diagnosed in 83.4% of patients in the continuous sample, while it reached the level of dementia in 16.9%. Therapy aimed at achieving and maintaining blood pressure (BP) targets did not lead to the regression of MCI. However, BP correction in combination with a 24-week piribedil therapy cycle was optimal in patients with CI. By the end of treatment, the Montreal Cognitive Assessment (MoCa) scores increased from 24.5Ѓ}0.8 to 27.5Ѓ}0.6 (p<0.05) and from 24.9Ѓ}0.7 to 27.1Ѓ}0.8 (p<0.05) in the groups of patients randomized to supplemental piribedil alone or in combination with nootropic and/or vascular drugs, respectively. There were no intergroup differences in the groups of patients randomized to supplemental piribedil. The time course of cognitive changes in the further follow-up period showed a longterm positive effect of piribedil on cognitive function.Conclusion. It is necessary to regularly screen for cognitive dysfunction in hypertensive patients. The most effective treatment in combination with a long-term piribedil therapy cycle for hypertension-associated MCI was to promote the achievement and retention of blood pressure targets.
Effciency of a rehabilitation training method by means of special infant formulas in patients with ischemic stroke and neurogenic dysphagia as part of combined therapy
Authors: Ershov V. I. , Belkin A. A. , Karpets A. V. , Zdvizhkova S. V. , Gonchar-Zaikin A. P. , Gumalatova N. V. 
Published: June 2019

Objective: to evaluate the efficiency of a training method using special infant formulas as part of combined rehabilitation for patients with ischemic stroke and neurogenic dysphagia.Patients and methods. The investigation enrolled 55 patients (30 men and 25 women) aged 45–80 years with dysphagia during the acute period of ischemic stroke. Thirty patients used special astringent formulas as part of combined therapy and 25 patients did not. The investigators studied the time of course of changes in the restoration of swallowing function, by using the Penetration-Aspiration Scale (PAS) and the Fiberoptic Endoscopic Dysphagia Severity Scale (FEDSS), as well as the transition from probe feeding to independent one.Results and discussion. The best restoration of swallowing function was shown to be achieved through training using formulas with different astringency. Stronger astringent formulas, like solid foods, stimulate better the pharyngeal receptor apparatus; the most active restoration of a dynamic swallowing stereotype occurs. The gradual transition to a milder astringent formula allows restoration of the skill to swallow thinner liquid foods. It takes 10 days to achieve a significant clinical effect in most patients, mainly in those with pseudobulbar disorders. Training may be prolonged to 2 weeks or more in severe cases, in bulbar dysfunctions.Conclusion. The training rehabilitation method using special infant formulas in combination with electrical stimulation in patients with ischemic stroke and neurogenic dysphagia allows achieving the significantly better indicators of restoration of swallowing function in accordance with the PAS scale. The application of the method contributes to the significantly better transition from probe feeding to independent one.
“Christian Charity”, A Sacred American Text
Authors: McGann Jerome 
Published: June 2019

The ideological status of “A Modell of Christian Charity” as a foundational American document began in 1838 when its existence was first made public. For the subsequent 150 years its character and in particular its authorship was a settled matter. But some 25 years ago Hugh Dawson began to raise questions about the work when he undertook an examination of the original document, a focus that previous scholars had neglected. It turns out that more searching documentary inquiries expose a whole set of anomalous features of the MS itself as well as its historical transmission. Because the status of this famous work is now quite unsettled, its case highlights why archival and philological method are the source and end and test of interpretation.
OUTCOMES OF INTERBODY FUSIONAND ARTHROPLASTY FOR CERVICAL SPINE DEGENERATIVE DISEASE
Authors: Glukhikh Dmitry Leonidovich 
Published: June 2019

Objective.To compare the results of interbody fusion and arthroplasty in patients with cervical spine degenerative disease.Material and Methods.Thirty-seven Bryan cervical discs prosthesis were implanted in 31 patients after discectomy (Group 1). Interbody fusion was performed in 47 patients (Group 2). Comprehensive survey of all patients was performed preoperatively, immediately postoperatively, at 3, 6, 9, 12, and 24 months after surgery. A visual analogue scale (VAS), the scale of disability assessment, radiography, MSCT, and MRI were used.Results.VAS assessment showed that in patients from Group 1 the pain relieved in the arm by 62.37 %, in the neck – by 38.75 %, and in Group 2 in the arm – by 38.75 % and in the neck – by 35.59 %. Quality of life improved by 53.18 % in Group 1 and by 30.34 % in Group 2. Adjacent segment degeneration within 24 months after surgery was observed in 5.30 % of patients from Group 1 and in 55.00 % of patients from Group 2. There were no subsidence and displacement of prostheses in the Bryan Group. In the Group of interbody fusion 35.00 % of patients showed subsidence and nonunion between implants and vertebrae of the operated segment.Conclusion.Arthroplasty provided better clinical and radiographic results in early and long-term postoperative periods.
Emotions as Context: Do the Naturalistic Effects of Emotion Regulation Strategies Depend on the Regulated Emotion?
Authors: Southward Matthew W. , Heiy Jane E. , Cheavens Jennifer S. 
Published: June 2019

Introduction: Researchers have examined how several contexts impact the effectiveness of emotion regulation strategies. However, few have considered the emotion-to-be-regulated as a context of interest. Specific emotions are important contexts because they may require particular responses to internal and external stimuli for optimal regulation.Method: Ninety-two undergraduates completed 10 days of ecological momentary assessment, reporting their current mood, recent emotions, and emotion regulation strategies three times per day.Results: The frequency with which certain emotion regulation strategies were used (i.e., acceptance, positive refocusing, reappraisal, problem-solving, and other-blame) differed by the specific emotion experienced. Acceptance and positive refocusing were associated with better mood regardless of emotion, while substance use was associated with worse mood regardless of emotion. Reappraisal was associated with better mood in response to anger than anxiety or sadness, while emotional suppression and other-blame were associated with worse mood in response to anger.Discussion: These results suggest some emotion regulation strategies exhibit emotion-invariant effects while others depend on the emotion-to-be-regulated.