bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel computer navigation method for accurate percutaneous sacroiliac screw implantation
Authors: Yu Tong , Zheng Shuang , Zhang Xiwen , Wang Dongsheng , Kang Mingyang , Dong Rongpeng , Qu Yang , Zhao Jianwu 
Published: February 2019

Abstract
The purpose of this study was to assess the accuracy of percutaneous sacroiliac screw (PSS) placement assisted by screw view model of navigation system for treatment of sacroiliac fractures.
Data pertaining to 18 consecutive patients with posterior pelvic ring fracture who received sacroiliac screw fixation between January 2015 and July 2018 at the Second Hospital of Jilin University were retrospectively analyzed. Kirschner wires were placed under the guidance of navigation's screw view mode. The position of the screws was evaluated by computed tomography (CT) scan postoperatively. Fracture dislocation of sacroiliac joint was measured in axial, sagittal, and coronal views of 3 dimensional (3D) CT images preoperatively, postoperatively and at the last follow-up visit. The duration of trajectory planning, guide wire implantation time, screw placement time, intraoperative blood loss, and incidence of screw loosening and clinical complications were also assessed.
A total of 27 screws were placed unilaterally or bilaterally into segments S1 or S2. Screw placement was rated as excellent for 88.9% of screws (n = 24), good for 7.4% (n = 2), and poor for 3.7% (n = 1). Preoperatively, the average fracture dislocation of sacroiliac joint on axial, sagittal, and coronal views was 14.3 mm, 9.6 mm, and 7.4 mm, respectively, and the corresponding postoperative figures were 5.6 mm, 3.2 mm, 4.1 mm, respectively. The corresponding correction rates were 60.8%, 66.7%, and 44.6%, respectively. The mean duration of trajectory planning was 6.5 min (2.7–8.9 min). Mean screw implantation time was 32 min (range, 20–53 min), and the mean guide wire implantation time was 3.7 min (range, 2.1–5.3 min). No clinical complications such as neurovascular injury, infection or screw loosening were observed on follow-up.
The PSS placement under guidance of screw view model of navigation is a convenient, safe and reliable method.
Dual anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane antibody-positive crescent glomerulonephritis in a patient with monoclonal gammopathy of undetermined significance
Authors: Li Xiaoli , Hao Yunfei , Xue Rong , Qi Xueting , Ma Zhigang 
Published: February 2019

Abstract

Rationale:
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and anti-glomerular basement membrane (GBM) antibody disease are both rare autoimmune diseases. Monoclonal gammopathy of undetermined significance (MGUS) is one of the most common causes of plasma cell dyscrasias (PCD). The three entities can cause renal lesions via different mechanisms and, however, they have not been reported in a single patient with renal lesion.

Patient concerns:
Here, we describe a patient with half-year fatigue and 40-day nausea and vomiting. Laboratory workup displayed increased serum creatinine, proteinuria, and mild microscopic hematuria. Serological tests were positive for anti-nuclear antibody (titer 1:100), anti-GBM antibodies (not quantified), and myeloperoxidase (MPO)-ANCA (228 RU/ml). Serum immunofixation electrophoresis found monoclonal immunoglobulin (MIg) G κ-light chain in the serum. Renal biopsy displayed crescentic formation in glomerule by microscopy and staining for liner IgG (+), sparse C3 (+-) and light chain (κ and λ) (+-) by immunofluorescence. The bone marrow examination indicated basically normal myelogram and sporadic plasma cells positive for CD38, CD138 staining, and κ light-chain restriction.

Diagnosis:
Crescentic glomerulonephritis and MGUS.

Interventions:
The patient was treated with plasmapheresis, pulse methylprednisolone therapy in combination with cyclophosphamide.

Outcomes:
The patient still became hemodialysis-dependent.

Lessons:
The present study discusses, to the best of our knowledge, first case of crescentic glomerulonephritis seropositive for ANCA anti-GBM antibody in MGUS. The rare concurrence highlights it as a clinical concern.
Pneumocystis jirovecii pneumonia as an initial manifestation of hyper-IgM syndrome in an infant
Authors: Kim Danbi , Shin Ju Ae , Han Seung Beom , Chung Nack-Gyun , Jeong Dae Chul 
Published: February 2019

Abstract

Rationale:

Pneumocystis jirovecii causes severe pneumonia in immunocompromised hosts. Human immunodeficiency virus infection, malignancy, solid organ or hematopoietic cell transplantation, and primary immune deficiency compose the risk factors for Pneumocystis pneumonia (PCP) in children, and PCP can be an initial clinical manifestation of primary immune deficiency.

Patient concerns:
A 5-month-old infant presented with cyanosis and tachypnea. He had no previous medical or birth history suggesting primary immune deficiency. He was diagnosed with interstitial pneumonia on admission.

Diagnoses:
He was diagnosed with PCP, and further evaluations revealed underlying X-linked hyper-IgM syndrome.

Interventions:
He was treated with trimethoprim/sulfamethoxazole for PCP, and eventually received allogeneic hematopoietic cell transplantation for hyper-IgM syndrome.

Outcomes:
Twenty months have passed after transplantation without severe complications.

Lessons:
PCP should be considered in infants presenting with severe interstitial pneumonia even in the absence of evidence of immune deficiency. Primary immune deficiency should also be suspected in infants diagnosed with PCP.
Efficacy of PCV vaccine is primarily mediated by controlling pneumococcal colonisation density
Authors: German E.L. , Solórzano C. , Sunny S. , Dunne F. , Gritzfeld J.F. , Mitsi E. , Nikolaou E. , Hyder-Wright A.D. , Collins A.M. , Gordon S.B. , Ferreira D.M. 
Published: February 2019

AbstractWidespread use of Pneumococcal Conjugate Vaccines (PCV) has resulted in a reduction in nasopharyngeal colonisation and invasive pneumococcal disease caused by vaccine-types. In a double-blind, randomised controlled trial using the Experimental Human Pneumococcal Challenge (EHPC) model, PCV-13 (Prevenar-13) conferred 78% protection against colonisation acquisition and a reduction in bacterial intensity (AUC) in experimentally colonised volunteers as measured by classical culture. In this study, we used a multiplex quantitative PCR assay targeting lytA and pneumococcal serotype 6A/B cpsA genes to re-assess the experimental colonisation status of the same trial volunteers. Increase in detection of low-density colonised volunteers by this molecular method led to a decrease of PCV efficacy against colonisation acquisition (29%), as compared to classical culture (83%). For subjects who were colonised following pneumococcal challenge, PCV had a pronounced effect on decreasing colonisation density. These results have implications for vaccine efficacy and surveillance studies as they indicate that the success of PCV vaccination could primarily be mediated by the control of vaccine-type colonisation density which results in decreased transmission and the reported herd effect of PCVs. Studies assessing the impact of PCV should account for density measurements in their design.Clinical trial registration with ISRCTN: 45340436
Transcriptional signatures of progressive neuropathology in transgenic tau and amyloid mouse models
Authors: Castanho Isabel , Murray Tracey K. , Hannon Eilis , Jeffries Aaron , Walker Emma , Laing Emma , Baulf Hedley , Harvey Joshua , Randall Andrew , Moore Karen , O’Neill Paul , Lunnon Katie , Collier David A. , Ahmed Zeshan , O’Neil Michael J. , Mill Jonathan 
Published: February 2019

AbstractThe onset and progression of Alzheimer’s disease (AD) is characterized by increasing intracellular aggregation of hyperphosphorylated tau protein and accumulation of β-amyloid (Aβ) in the neocortex. Despite recent success in identifying genetic risk factors for AD the transcriptional mechanisms involved in disease progression are not fully understood. We used transgenic mice harbouring human tau (rTg4510) and amyloid precursor protein (J20) mutations to investigate transcriptional changes associated with the development of both tau and amyloid pathology. Using highly-parallel RNA sequencing we profiled transcriptional variation in the entorhinal cortex at four time points identifying robust genotype-associated differences in entorhinal cortex gene expression in both models. We quantified neuropathological burden across multiple brain regions in the same individual mice, identifying widespread changes in gene expression paralleling the development of tau pathology in rTg4510 mice. Differentially expressed transcripts included genes associated with familial AD from genetic studies of human patients, and genes annotated to both common and rare variants identified in GWAS and exome-sequencing studies of late-onset sporadic AD. Systems-level analyses identified discrete co-expression networks associated with the progressive accumulation of tau, with these enriched for genes and pathways previously implicated in the neuro-immunological and neurodegenerative processes driving AD pathology. Finally, we report considerable overlap between tau-associated networks and AD-associated co-expression modules identified in the human cortex. Our data provide further support for an immune-response component in the accumulation of tau, and reveal novel molecular pathways associated with the progression of AD neuropathology.
Plasma pNfH differentiate SBMA from ALS
Authors: Lombardi Vittoria , Alessandro Bombaci , Zampedri Luca , Lu Ching-Hua , Malik Bilal , Zetterberg Henrik , Heslegrave Amanda , Rinaldi Carlo , Greensmith Linda , Hanna Michael , Malaspina Andrea , Fratta Pietro 
Published: February 2019

AbstractBackground and aim:Spinal bulbar muscular atrophy (SBMA) is a progressive adult-onset X-linked neuromuscular disease. Although traditionally considered a motor neuron disorder, recent advances have highlighted a primary myopathic component. We evaluated levels of phosphorylated neurofilament heavy chain (pNfH), a known biomarker for neurodegeneration, in SBMA.Materials and methods:We collected plasma and serum from 46 SBMA, 50 ALS and 50 healthy control cases, alongside with plasma from a mouse model of SBMA (AR100) and littermate controls. We measured pNfH plasma levels using Single molecule array (Simoa), we assessed functional scales and we gathered demographic data. We analysed data using Mann-Whitney U test, Kruskal-Wallis test and Cox regression analysis.Results:Plasma pNfH levels were significantly increased in ALS, but, intriguingly, there was no change in SBMA. These results were also confirmed in SBMA mice. The ROC curve highlighted that pNfH levels can effectively distinguish between ALS and SBMA (AUC 0.95).Conclusions:Unexpectedly, levels of pNfH are normal in SBMA, whilst they are increased in ALS, and suggest pNfH could serve as a biomarker to differentiate the two diseases. Further, this finding is in agreement with recent evidence showing that primary muscle damage is a crucial feature in SBMA.
Sulfide stress cracking assessment of low-alloy L80 casing steel in H2S environment
Authors: Huang Weishan , Luo Jing-Li , Henein Hani , Jordan Josiah 
Published: February 2019

Purpose
This paper aims to evaluate the sulfide stress cracking (SSC) resistance of L80 casing steels with different alloying chemistries (e.g. Ti-B and Mn-Cr-Mo) by correlating the reduction in area ratio with the mechanical property, inclusion and carbide.

Design/methodology/approach
SSC tests were conducted in 5.0 Wt.% sodium chloride and 0.5 Wt.% acetic acid solution saturated with H2S using constant load tensile method. The microstructure and fracture morphology of the steel were observed using scanning electron microscope. The inclusion and carbide were identified by energy dispersive spectroscopy and auger electron microscope.

Findings
Among all the testing steels, electric resistance welding (ERW) L80-0.5Mo steel demonstrates the highest SSC resistance because of its appropriate mechanical properties, uniform microstructure and low inclusion content. The SSC resistance of L80 steels generally decreases with the rising yield strength. The fracture mode of steel with low SSC resistance is jointly dominated by transgranular and intergranular cracking, whereas that with high SSC resistance is mainly transgranular cracking. SSC is more sensitive to inclusions than carbides because the cracks are easier to be initiated from the elongated inclusions and oversized oxide inclusions, especially the inclusion clusters. Unlike the elongated carbide, globular carbide in the steel can reduce the negative effect on the SSC resistance. Especially, a uniform microstructure with fine globular carbides favors a significant improvement in SSC resistance through precluding the cracking propagation.

Originality/value
The paper provides the new insights into the improvement in SSC resistance of L80 casing steel for its application in H2S environment through optimizing its alloying compositions and microstructure.
Got political skill?
Authors: Kim Taegoo Terry , Karatepe Osman M. , Chung Ung Young 
Published: February 2019

PurposeThe purpose of this study is to propose a research model in which political skill (PS) exerts a direct effect on role stress, job tension, work engagement and service performance and buffers the deleterious impact of role stress on job tension. The model also investigates the interrelationships of role stress, job tension, work engagement and service performance.Design/methodology/approachThe sample was drawn from 261 customer-contact employees in 15 casual restaurants in South Korea. Structural equation modeling was used to assess the aforementioned relationships.FindingsThe findings illustrate that PS alleviates role stress and job tension, while it fosters work engagement and service performance. PS is a panacea to the deleterious impact of role stress on job tension. As expected, role stress heightens job tension, while job tension mitigates work engagement. The findings further reveal that work engagement exerts a positive impact on service performance.Practical implicationsTraining interventions can be used to develop employees’ PS. Management should hire the individuals with high PS because such employees can work in harmony with the organizational culture and experience lower role stress and job tension.Originality/valueThe extant hospitality research implicitly demonstrates that very little is known about the outcomes of PS and its moderating role on the relationship between role stress and job tension. The current work set out to fill in this gap.
Cross-border nursing education: questions, qualms and quality assurance
Authors: Naidoo Vasanthrie , Sibiya Maureen Nokuthula 
Published: February 2019

Purpose
The purpose of this paper is to share insights, research findings and discuss key issues relating to quality practices and quality assurance in cross-border nursing education program development and implementation.

Design/methodology/approach
The authors used a qualitative, multiple case-study approach, by sampling local, national and international nursing education institutions, academia and nurse graduates to identify challenges and best operating practices in implementing and facilitating cross-border education.

Findings
The authors reveal that quality assurance affects cross-border nursing education program design, delivery and implementation.

Research limitations/implications
Quality assurance plays an important role in cross-border nursing education, by enhancing the reputation and recognizing the effectiveness and capacity of the educational institution. These findings of this study can offer valuable insight to forthcoming as well as existing nursing education curriculum developers who plan to engage in national or international educational partnerships.

Practical implications
Quality assurance plays an important role in cross-border nursing education, by enhancing the reputation and recognizing the educational institution’s effectiveness and capacity. The findings offer valuable insight into forthcoming and existing nursing education for curriculum developers who plan to engage in national or international educational partnerships.

Originality/value
This paper explores inherent challenges in cross-border nursing education and maximized data collection opportunities by sampling participants from both national and international settings.
Hospital quality indicators: a systematic review
Authors: Breyer Juliana Zeni , Giacomazzi Juliana , Kuhmmer Regina , Lima Karine Margarites , Hammes Luciano Serpa , Ribeiro Rodrigo Antonini , Kops Natália Luiza , Falavigna Maicon , Wendland Eliana Marcia 
Published: February 2019

Purpose
The purpose of this paper is to identify and describe hospital quality indicators, classifying them according to Donabedian’s structure, process and outcome model and in specific domains (quality, safety, infection and mortality) in two care divisions: inpatient and emergency services.

Design/methodology/approach
A systematic review identified hospital clinical indicators. Two independent investigators evaluated 70 articles/documents located in electronic databases and nine documents from the grey literature, 35 were included in the systematic review.

Findings
In total, 248 hospital-based indicators were classified as infection, safety, quality and mortality domains. Only 10.2 percent were identified in more than one article/document and 47 percent showed how they were calculated/obtained. Although there are scientific papers on developing, validating and hospital indicator assessment, most indicators were obtained from technical reports, government publications or health professional associations.

Research limitations/implications
This review identified several hospital structure, process and outcome quality indicators, which are used by different national and international groups in both research and clinical practice. Comparing performance between healthcare organizations was difficult. Common clinical care standard indicators used by different networks, programs and institutions are essential to hospital quality benchmarking.

Originality/value
To the authors’ knowledge, this is the first systematic review to identify and describe hospital quality indicators after a comprehensive search in MEDLINE/PubMed, etc., and the grey literature, aiming to identify as many indicators as possible. Few studies evaluate the indicators, and most are found only in the grey literature, and have been published mostly by government agencies. Documents published in scientific journals usually refer to a specific indicator or to constructing an indicator. However, indicators most commonly found are not supported by reliability or validity studies.
Why do natives and non-natives have different housing outcomes? Evidence from Britain
Authors: Oladiran Olayiwola , Nanda Anupam , Milcheva Stanimira 
Published: February 2019

PurposeThis study aims to examine the housing outcomes of natives and multiple generations of non-natives using a longitudinal survey data in Britain.Design/methodology/approachThe authors use longitudinal data from Britain, in which they can observe multiple generations of immigrants and their demographic and economic information.FindingsThe probability models for housing tenure reveal significant variation in the outcomes which are robust to several econometric specifications.Research limitations/implicationsAs migration and its impact on local economy is a highly debated topic across several major regions of the world, the findings bring out important insights with policy implications. The research is limited by the sample size of the longitudinal survey.Originality/valueThe empirical evidence on the topic is quite limited with mixed findings. Especially, the authors’ ability to look through multiple generations is unique in identifying the variation in housing outcomes for the native and non-native citizens.
Last mile delivery to the bottom of the pyramid in Brazilian slums
Authors: Duarte André Luis de Castro Moura , Macau Flavio , Flores e Silva Cristiano , Sanches Lars Meyer 
Published: February 2019

Purpose
The purpose of this paper is to explore last mile delivery (LMD) to the bottom of the pyramid in Brazilian slums, its challenges and how practitioners overcome them. Urban logistics in precarious circumstances is central to the conceptualization.

Design/methodology/approach
A qualitative, grounded theory methodology is developed, gathering data from companies delivering to slums in Sao Paulo and Rio de Janeiro, Brazil. Field notes, documents and interviews led to conceptual categories for LMD to slums.

Findings
The study indicates that while some standard urban logistics practices can be effective for LMD to slums, such unusual contexts often call for unusual solutions. A model is developed using grounded theory categorization, resulting in five dimensions for LMD to slums: employing locally, giving back, acknowledging criminals, vehicle and location.

Research limitations/implications
The model is a qualitative proposition representing LMD to slums in two major Brazilian cities. Even though slums in different cities/countries may face similar conditions, additional studies are needed to confirm and replicate the model.

Practical implications
Companies that successfully engage in LMD to slums must adapt and develop idiosyncratic practices.

Social implications
LMD to slums enables a larger portion of bottom of the pyramid consumers to access a wider range of products and work opportunities, contributing to their social inclusion.

Originality/value
The study provides an understanding of LMD in a new context. The model encourages companies to question their current practices, learning from effective LMD experiences implemented by successful practitioners.
Experiential approaches to sustainability education: towards learning landscapes
Authors: Backman Malin , Pitt Hannah , Marsden Terry , Mehmood Abid , Mathijs Erik 
Published: February 2019

Purpose
This paper aims to critically reflect the current specialist discourse on experiential approaches to higher education for sustainable development (HESD). Limitations to the current discourse are identified, and as a result, an alternative approach to the study of experiential education (EE) within HESD is suggested.

Design/methodology/approach
Three research questions are addressed by analysing the literature on EE and experiential learning (EL) within HESD in specialist academic journals.

Findings
There is a consensus among authors regarding the appropriateness of experiential approaches to HESD. However, limitations to the current discourse suggest the need for an alternative approach to studying EE within HESD. Therefore, this paper proposes the application of the learning landscape metaphor to take a more student-centred and holistic perspective.

Originality/value
The learning landscape metaphor has previously not been applied to EE within HESD. This alternative conceptualisation foregrounds student perspectives to experiential initiatives within HESD. The holistic approach aims to understand the myriad influences on students learning, while allowing examination of how experiential approaches relate to other educational approaches within HESD.