bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non-coding RNA in osteogenesis
Authors: Zhang J. , Hao X. , Yin M. , Xu T. , Guo F. 
Published: February 2019

Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides with limited coding potential, which have emerged as novel regulators in many biological and pathological processes, including growth, development, and oncogenesis. Accumulating evidence suggests that lncRNAs have a special role in the osteogenic differentiation of various types of cell, including stem cells from different sources such as embryo, bone marrow, adipose tissue and periodontal ligaments, and induced pluripotent stem cells. Involved in complex mechanisms, lncRNAs regulate osteogenic markers and key regulators and pathways in osteogenic differentiation. In this review, we provide insights into the functions and molecular mechanisms of lncRNAs in osteogenesis and highlight their emerging roles and clinical value in regenerative medicine and osteogenesis-related diseases. Cite this article: J. Zhang, X. Hao, M. Yin, T. Xu, F. Guo. Long non-coding RNA in osteogenesis: A new world to be explored. Bone Joint Res 2019;8:73–80. DOI: 10.1302/2046-3758.82.BJR-2018-0074.R1.
Effect of Health and Training on Ultrasensitive Cardiac Troponin in Marathon Runners
Authors: Bishop Emily N , Dang Tam , Morrell Heather , Estis Joel , Bishop Jeffrey J 
Published: February 2019

Abstract

Purpose
Cardiac troponin (cTn) is the gold standard biomarker for assessing cardiac damage. Previous studies have demonstrated increases in plasma cTn because of extreme exercise, including marathon running. We developed an easy-to-use, ultrasensitive assay for cardiac troponin I (cTnI) by combining single-molecule counting (SMC™) technology with dried blood spot (DBS) collection techniques and validated the assay on a cohort of marathon runners by correlating postmarathon cTnI elevations with training or risk variables.

Methods
An SMC-DBS method was developed for accurate and reproducible measurement of cTnI in fingerstick whole blood. Samples were collected from 42 runners both before and immediately after running a marathon. A similar collection was obtained from 22 non-running control individuals. Pre- and postrace questionnaires containing health and training variables were correlated with cTnI concentration.

Results
The assay quantified cTnI in all controls and marathon runners, both before and after the race. Prerace concentrations were significantly higher in marathon runners vs controls (median 3.1 vs 0.4 pg/mL; P &lt; 0.0001). Immediate postmarathon concentrations were increased in 98% of runners (median elevation, 40.5 pg/mL; P &lt; 0.001), including many above traditional cutoffs for acute myocardial infarction. Several health and training variables trended toward significant correlation with cTnI elevations.

Conclusion
While further studies are needed to better understand the mechanisms and clinical implications of exercise-induced cTnI elevations, the present study suggests several variables that may be associated with such elevations and demonstrates a simple, cost-effective method for monitoring cTnI during exercise, managing chronic disease, and/or for assessing risk in large populations.
Recentrifugation of Lithium Heparin Gel Separator Tubes up to 8 h after Blood Collection Has No Relevant Influence on the Stability of 30 Routine Biochemical Analytes
Authors: van Balveren Jasmijn A , Gemen Eugenie F A , Kusters Ron 
Published: February 2019

Abstract

Background
Venipuncture for the purpose of blood analysis is often performed at remote locations, and samples may be centrifuged locally to preserve the integrity of analytes. At the central laboratory, these tubes may be centrifuged again in the routine process. However, limited research shows that &gt;1 centrifugation cycle of gel separator tubes causes significant changes in analytes, in particular troponin I and potassium. These preanalytical test changes are undesirable and may lead to errors in diagnosis and treatment of patients.

Methods
Ten volunteers donated blood in 10 lithium heparin gel tubes. Per volunteer, 5 tubes were centrifuged with Becton Dickinson centrifugation settings and 5 tubes with our local centrifugation settings. For each centrifugation setting, 1 tube was centrifuged directly after venipuncture; the second tube, directly after venipuncture and again after 4 h; the third tube, directly after venipuncture and again after 8 h; the fourth tube, 4 h after venipuncture; the last tube, 8 h after venipuncture. Thirty routine chemistry analyses were performed in plasma directly after the last centrifugation cycle. All tubes were kept at room temperature. Analytes were considered unstable when the mean percentage deviation exceeded the total allowable error.

Results
Except for calcium, which slightly exceeded the predefined total allowable error limit, all the investigated analytes remained stable up to 8 h after a second centrifugation cycle with both centrifugation settings.

Conclusion
This study shows that recentrifugation up to 8 h after blood collection does not cause relevant deviations in test results and may be applied safely.
ANALYZING LAND USE PATTERN CHANGES IN MUKIM PENGERANG, JOHOR, MALAYSIA
Authors: Che Man Noordini Binti , Salihin Anis Farhan Binti 
Published: February 2019

Urbanization and urban land-use transition have a competitive environment to ensure and provide good facilities for citizen benefit. The landscape patterns resulting from urbanization effect processes at local, regional, and global scales. Quantifying the spatiotemporal pattern of urbanization is important for understanding its ecological impacts and can provide basic information for appropriate decision-making. The growth of urbanization in Mukim Pengerang, Johor, has undergone rapid changes in agriculture, settlements, townships and various activities. The changes of land use take place in Mukim Pengerang due to the rapid economic development, especially in industrializations which are Refinery and Petrochemical Integrated Development (RAPID) project and Pengerang Integrated Petroleum Complex (PIPC). The industrialization boosts the growth in land property and commercial which progressing in rapid development since the year 2012, in resulting whether it can give good, bad or both impact to the human and surrounding. Therefore, the main aim of this paper is to quantify the changes in landscape pattern or land use pattern between the year 2008 and 2017 occurred in Mukim Pengerang. In monitoring the spatial pattern changes, and the changes of landscape structure, the metrics landscape were analyzed with determination of the Shanon Diversity Index (SHDI), the number of patches (NP), Edge Density (ED) and Total Edge (TE) in the period of 8 years. The results show that the changes occurred with the three types of land use showed significant changes in the types of land use which are forest, agricultural and built-up area. The result of SHDI analysis shows the increment value between the year 2008 and 2017. This situation illustrates that the higher value of SHDI for an area, resulting in the higher level of land use. This is because the growing pattern of land use is reflected by a large number of patches due to the diversification of land use activities in the area. As a result, from the metrics statistics test verifies there was a significant change in land use that took place within 8 years.
Congressional Midterm Forecasts: A Trump Economic Difference?
Authors: Tien Charles , Lewis-Beck Michael S. 
Published: February 2019

Abstract
Among certain politicians, pundits and people, the expectation was that President Trump would make an economic difference in the 2018 congressional elections. In particular, the belief was that his economic appeal, coupled with his economic policies, would favor Republican candidates. However, an application of the classic referendum model for forecasting congressional outcomes shows no detectable Trump economic effect. That is, the economic conditions prevailing prior to the election, measured in multiple ways, worked as usual, helping to predict the actual Republican 40 seat loss rather closely. Put another way, any incumbent administration, faced with this set of numbers, would likely have experienced the same outcome. In sum, the Trump presence, in its economic manifestations, did not positively impact the Republican party fortune at midterm time.
Affirmations for an Aging Electoral Order: The Mid-Term Elections of 2018
Authors: Shafer Byron E. , Wagner Regina L. 
Published: February 2019

Abstract
At bottom, the election of 2018 produced one more iteration of an electoral order dominating American politics since 1992. So the main task of this paper is to elicit the structure of that order, drop the results of 2018 into it, and see how well those results fit. The key micro-analytic tools for approaching any election did work well in 2018, but cannot distinguish this election from other recent contests. The common journalistic focus on idiosyncratic elements of stability but especially change provides no real means of analyzing either. With the result that a focus on the structure of the modern American political world has to provide the tools for unpacking what proves to be an impressively stable electoral pattern.
Cardiovascular risk estimated by UKPDS risk engine algorithm in diabetes
Authors: Kavaric Nebojsa , Klisic Aleksandra , Ninic Ana 
Published: February 2019

Abstract
Since there is a high prevalence of type 2 diabetes mellitus (DM2), as well as CVD in Montenegro, we aimed to estimate CVD risk by United Kingdom Prospective Diabetes Study (UKPDS) risk engine algorithm in individuals with DM2. Furthermore, we aimed to explore whether non-traditional biomarker such as high sensitivity C-reactive protein (hsCRP) is superior for CVD risk prediction over old traditional risk factors. A total of 180 participants with DM2 (of them 50% females) were included in the current cross-sectional study. Biochemical and anthropometric parameters, and blood pressure were obtained. More males than females were classified at high UKPDS risk category (p<0.001). Also, about one third of diabetic patients (29.4%) were classified into the high-risk category. In multivariate regression analysis, triglycerides [Odds ratio (OR) =1.703, p=0.001] and creatinine concentration (OR=1.040, p<0.001) were independent predictors of CVD risk, whereas hsCRP was not correlated with CVD risk. HsCRP is not superior for CVD risk prediction by UKPDS risk engine algorithm over high triglyceride and creatinine levels in diabetic population, which suggests that the old traditional markers must not be underestimated when examining CVD risk in population with diabetes.
Link-Based Clustering Algorithm for Clustering Web Documents
Authors: Ashokkumar P. , Don S. 
Published: February 2019

Abstract
Clustering web documents involves the use of a large amount of words to be inputted to clustering algorithms such as K-Means, Cosine Similarity, Latent Discelet Allocation, and so on. This causes the clustering process to consume much time as the number of words in each document increases. In many web documents, web links are available along with the contents; these web link texts may contain a tremendous amount of information for clustering. In our work, we show that just using the web link text alone gives better clustering efficiency than considering the whole document text. We implemented our algorithm with two benchmark datasets, and the results show that the clustering efficiency is increased by our algorithm more than the existing methods.
Synthesis of YAG:Ce/ZnO core/shell nanoparticles with enhanced UV-visible and visible light photocatalytic activity and application for the antibiotic removal from aqueous media
Authors: Zammouri Lobna , Aboulaich Abdelhay , Capoen Bruno , Bouazaoui Mohamed , Sarakha Mohamed , Stitou Mostafa , Mahiou Rachid 
Published: February 2019

Abstract
Modeling Short-Term and Long-Term Dependencies of the Speech Signal for Paralinguistic Emotion Classification
Authors: Verkholyak Oxana , Kaya Heysem , Karpov Alexey 
Published: February 2019

Recently, Speech Emotion Recognition (SER) has become an important research topic of affective computing. It is a difficult problem, where some of the greatest challenges lie in the feature selection and representation tasks. A good feature representation should be able to reflect global trends as well as temporal structure of the signal, since emotions naturally evolve in time; it has become possible with the advent of Recurrent Neural Networks (RNN), which are actively used today for various sequence modeling tasks. This paper proposes a hybrid approach to feature representation, which combines traditionally engineered statistical features with Long Short-Term Memory (LSTM) sequence representation in order to take advantage of both short-term and long-term acoustic characteristics of the signal, therefore capturing not only the general trends but also temporal structure of the signal. The evaluation of the proposed method is done on three publicly available acted emotional speech corpora in three different languages, namely RUSLANA (Russian speech), BUEMODB (Turkish speech) and EMODB (German speech). Compared to the traditional approach, the results of our experiments show an absolute improvement of 2.3% and 2.8% for two out of three databases, and a comparative performance on the third. Therefore, provided enough training data, the proposed method proves effective in modelling emotional content of speech utterances.
Successful Treatment of Pleuropulmonary Blastoma with Multiple Bone Metastases: Case Study
Authors: Gorokhova E. V. , Kachanov D. Y. , Shamanskaya T. V. , Macekha E. P. , Chililova A. M. , Teleshova M. V. , Talypov S. R. , Roschin V. Y. , Konovalov D. M. , Shabat A. A. , Tereschenko G. V. , Varfolomeeva S. R. 
Published: February 2019

Background.Pleuropulmonary blastoma (PPB) is a rare primary embryonal tumor of the lung in children. Three main histological variants of PPB with a possible transformation of type I into type II and III are now described. The prognosis in pleuropulmonary blastoma patients with distant metastases is considered to be unfavorable.Case Report.The article presents the case of type I PPB development in a 14-month-old child followed by the transformation of type I PPB into type II in the setting of relapse with multiple bone metastases. The aim of the article was to provide reliable data on successful treatment and achievement of long-term event-free survival in a PPB patient with multiple bone metastases who underwent intensive chemotherapy and high-dose therapy with autologous hematopoietic stem cell transplantation.Conclusion. The case study demonstrates the possibility for achievement of long-term event-free survival in PPB patients with multiple bone metastases and relapses.
A case of mesenteric vein thrombosis developed in the first trimester of pregnancy after in vitro fertilization and embryo transfer in a patient with antiphospholipid syndrome
Authors: Stuleva N. S. , Vorobiev A. V. , Orudzhova E. A. 
Published: February 2019

Combined thrombophilia is known as a probable cause of recurrent in vitro fertilization (IVF) failures. The present clinical case demonstrates the importance of considering the possibility of inherited or acquired thrombophilia in patients under the preparation for IVF. Thromboses of rare locations (hepatic vein, splenic vein, mesenteric vein, ovarian vein, retinal vein, cerebral vein, portal vein, axillary and subclavian vein) are life-threatening conditions. Most often thrombosis of atypical location develops in patients with inherited hemostatic defects, e.g. genetic thrombophilia. Such thromboses can also result from acquired abnormalities of hemostasis, which include antiphospholipid syndrome, pregnancy-associated hypercoagulability, IVF, oral contraception, or ovarian hyper-stimulation within IVF procedures.
Comparative study to assess the outcome of omitting bladder flap formation from caesarean delivery
Authors: Gupta Pratiksha , Kumari Suman 
Published: February 2019

Background: The aim of this study is to evaluate the effects of omitting the step of bladder ﬂap formation at lower-segment caesarean delivery.Methods: It is a RCT (randomised control trial), non-blinded study conducted in a tertiary care hospital. A total of 104 women who underwent caesarean delivery (elective or emergency) were prospectively randomized to one of the two groups. In the study group (n= 54), caesarean was performed without formation of a bladder ﬂap. In the control group (n=50), caesarean was performed with the formation of a bladder ﬂap before the uterine incision.Results: There were differences of median skin incision to delivery interval (5 versus 6.5 minutes, P <0.0001), median total operating time (35 versus 44.5 minutes, P 0.0002), and median blood loss (haemoglobin 0.5 versus 1g/dl, P 0.0001) in favor of the study group. Postoperative incidence of urinary tract infection was reduced in the study group (1% versus 9%, P <0.0006) and bowel function returned early in the study group (day 2 versus 3, P<0.0001). Bladder flap formation step was successfully omitted in (11/18, 61.11%) of previous CS (caesarean section) patients in the study group and (7/12, 58.33%) in control group illustrating that unless required, BF (bladder flap) formation step can even be omitted in previous CS patients.Conclusions: Omission of the bladder ﬂap provides short term advantages such as reduction of total operating time, incision-delivery interval, and reduced blood loss and that this technique can even be applied in previous caesarean section patients.
Profile of unmet needs of family planning in an urban slum of Ganjam district, Odisha, India: a cross-sectional study
Authors: Sabat Smaranita , Jena Dhaneswari , Satapathy Durga Madhab , Patro Sithun , Tripathy Radhamadhab 
Published: February 2019

Background: Unmet need for family planning refers to the percentage of fecund women of reproductive age either married or in union, women who either wish to postpone the next birth (spacers) or who wish to stop child bearing (limiters) but are not using a contraceptive method. This clearly indicates a gap between a woman’s reproductive intention and current contraceptive behaviour. The objectives of the present study was to determine the prevalence of unmet need for family planning, to assess the association between socio-demographic characteristics and unmet need of family planning, to identify the reasons for unmet need.Methods: It was a cross-sectional study conducted from June to August 2018 in Ankuli (UHTC). A total of 188 ever married women in the reproductive age group were selected by simple random sampling.Results: Out of 188 women, 41 (21.8%) had no need for contraception and needs for family planning of 78 (41.5%) women had been met. The prevalence of unmet need for family planning was 36.7% consists of 24 (12.8%) spacing need and 45 (23.9%) limiting need. It was found that age, education of women, age at marriage, number of living children, contraceptive knowledge and inter-spousal communication were significantly associated with unmet need for family planning. The most common reason for not using any contraceptive method was fear of side effects (40.6%).Conclusions: The unmet need for family planning was high and in order to reduce the gap, the program should address the above reasons.
Role of sex hormone binding globulin as the early predictor for gestational diabetes mellitus
Authors: M. S. Sujatha , S. Madhana , P. Shylaja , S. Priyanka 
Published: February 2019

Background: The aim of this study was to find role of SHBG as an early predictor for gestational diabetes mellitus.Methods: A hospital based prospective/observational/diagnostic and explorative study. The necessary information was collected from the participants through the prepared set of questionnaires. Pregnant women between 11 to 14 weeks of gestation who visited JSS OPD for antenatal checkup satisfying inclusion and exclusion criteria giving informed and written consent for the study were examined clinically. 3ml of venous blood was drawn with aseptic precautions for the estimation of SHBG and adiponectin. OGTT with 75gms glucose first done at 11 to 14weeks and again at 24-28 weeks and 32-36 weeks were done to the same patient to find out whether the patient developed GDM or not. These mothers were followed periodically till delivery. The sensitivity and specificity of SHBG were assessed and compared in patients who developed GDM.Results: 100 cases were selected for the study. About 12 patients were diagnosed as gestational diabetes mellitus in present study by OGCT at 32 weeks to 36 weeks. In present study about 14 patients had low level of SHBG. Low level of SHBG is found to be statistically significant in predicting GDM in first trimester.Conclusions: The combination of SHBG can be used as predictor of GDM in first trimester.
Can single plasma glucose value 2 hours after 75g glucose (DIPSI criteria) replace the gold standard OGTT for the diagnosis of gestational diabetes mellitus?
Authors: Sharma Neeraj , Pundir Seema , Dinani Bunty 
Published: February 2019

Background: Gestational diabetes mellitus is a common medical complication of pregnancy associated with several fetal and maternal complications. There are several screening tools for detecting gestational diabetes mellitus including recent DIPSI criteria of non-fasting single plasma 2-hour value after 75 grams glucose (single step test). The present study was aimed at calculating prevalence of GDM, sensitivity and specificity using non-fasting single plasma 2-hour value after 75 grams glucose for screening and diagnosis of gestational diabetes mellitus and to study the high-risk characteristics for GDM in this study population.Methods: This was a prospective study conducted for a period of one year. 750 antenatal women attending Antenatal outpatient department(OPD) with period of gestation 24-28 weeks were enrolled in the study. All women were first tested by 75 gm glucose and then by OGTT for confirmation. Prevalence rates, sensitivity, specificity, positive predictive value and negative predictive value were studied. History based questionnaire was used to study the risk characteristics for GDM.Results: Prevalence rate, sensitivity, specificity, positive predictive value and negative predictive value for patients were 14.13%, 73.58%, 95.03%, 70.90% and 95.67%. Among the risk factors 7.2% patients were more than 30 years in age. 0.93% had GDM in previous pregnancy.4.21% had GCA in previous pregnancy, 12.4% had SB/IUD/NND in previous pregnancy. 1.17% had previous pregnancy with birth weight more than 3.5 kg and 9.73% had family history of diabetes mellitus. Past history of GDM (50%) was the most common risk factor in GDM group followed by age > 30 years (29.6%), and family history (24.6%).Conclusions: Screening using DIPSI criteria has good sensitivity and negative predictive values. It can serve as both screening and diagnostic test besides being simple, user friendly, cost effective and evidence-based test in less resource countries like India.