bluuebunny/crossref_metadata_2025_split huggingface dataset:
FACTORS INFLUENCING HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: Vorobyeva L. D. 
Published: September 2019

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects any organs and systems and is characterized by a wide range of various clinical manifestations. According to the treat-to-target strategy for SLE, in addition to monitoring disease activity and irreversible organ damage, it is necessary to assess health-related quality of life (HRQOL), which enables one to obtain a complete and objective description of the patient. All the factors and problems that may worsen HRQOL should be also taken into account. Fatigue, pain, and depression are identified as the major symptoms that largely affect HRQOL. The impact of cognitive impairment associated with the disease is also considered. Impaired body image, i.e. the perception of his own appearance by a patient himself, is an important problem in patients with SLE. The unpredictable course of the disease and the impaired physical functioning of patients make it difficult to perform everyday activities, as well as disturb socialization; the patients often experience of being dependent on others. Due to SLE, the patients are often limited in their choice of profession or forced to quit/change their jobs, which leads to financial losses and feelings of social isolation. The review also considers gender, age, and education as factors influencing HRQOL in patients with SLE.
ETODOLAC, A WELL KNOWN AND ACTIVELY USED DRUG IN DIFFERENT COUNTRIES OF THE WORLD. WOULD IT BE TIME FOR US?
Authors: Karateev A. E. 
Published: September 2019

Etodolac is a nonsteroidal anti-inflammatory drug (NSAID), a moderately selective cyclooxygenase-2 inhibitor, which has been already used in clinical practice for more than 30 years as a universal analgesic and anti-inflammatory agent. Etodolac has proven itself in relieving acute pain associated with injuries and surgical interventions (particularly in dentistry). However, the main point of application of etodolac is long-term pain control in chronic rheumatic diseases, such as osteoarthritis and rheumatoid arthritis. Numerous clinical trials have shown that etodolac is at least not inferior in its therapeutic effect to many other popular representatives of the NSAID group or exceeds them. The main advantage of etodolac is the low frequency of gastrointestinal complications. This review presents the basic data available in the literature on the efficacy and safety of etodolac.
Validation of a liquid chromatography tandem mass spectrometry (LC-MS/MS) method to detect cannabinoids in whole blood and breath
Authors: Hubbard Jacqueline A. , Smith Breland E. , Sobolesky Philip M. , Kim Sollip , Hoffman Melissa A. , Stone Judith , Huestis Marilyn A. , Grelotti David J. , Grant Igor , Marcotte Thomas D. , Fitzgerald Robert L. 
Published: September 2019

Abstract

Background
The widespread availability of cannabis raises concerns regarding its effect on driving performance and operation of complex equipment. Currently, there are no established safe driving limits regarding ∆9-tetrahydrocannabinol (THC) concentrations in blood or breath. Daily cannabis users build up a large body burden of THC with residual excretion for days or weeks after the start of abstinence. Therefore, it is critical to have a sensitive and specific analytical assay that quantifies THC, the main psychoactive component of cannabis, and multiple metabolites to improve interpretation of cannabinoids in blood; some analytes may indicate recent use.

Methods
A liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed to quantify THC, cannabinol (CBN), cannabidiol (CBD), 11-hydroxy-THC (11-OH-THC), (±)-11-nor-9-carboxy-Δ9-THC (THCCOOH), (+)-11-nor-Δ9-THC-9-carboxylic acid glucuronide (THCCOOH-gluc), cannabigerol (CBG), and tetrahydrocannabivarin (THCV) in whole blood (WB). WB samples were prepared by solid-phase extraction (SPE) and quantified by LC-MS/MS. A rapid and simple method involving methanol elution of THC in breath collected in SensAbues® devices was optimized.

Results
Lower limits of quantification ranged from 0.5 to 2 μg/L in WB. An LLOQ of 80 pg/pad was achieved for THC concentrations in breath. Calibration curves were linear (R2>0.995) with calibrator concentrations within ±15% of their target and quality control (QC) bias and imprecision ≤15%. No major matrix effects or drug interferences were observed.

Conclusions
The methods were robust and adequately quantified cannabinoids in biological blood and breath samples. These methods will be used to identify cannabinoid concentrations in an upcoming study of the effects of cannabis on driving.
Relationship between attenuated total reflectance Fourier transform infrared spectroscopy of western juniper and natural resistance to fungal and termite attack
Authors: Lipeh Shahlinney , Schimleck Laurence R. , Mankowski Mark E. , McDonald Armando G. , Morrell Jeffrey J. 
Published: September 2019

Abstract
Wood extractives are considered the major factor determining the natural durability of wood. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy was assessed for rapid determination of western juniper (Juniperus occidentalis Hook. var. occidentalis) durability based on extractives in heartwood, sapwood-heartwood and sapwood regions. Durability was assessed by exposing samples to brown-rot decay fungi [Gloeophyllum trabeum (Pers.) Murrill and Rhodonia placenta (Fr.) Niemelä, K.H. Larss. & Schigel] or eastern subterranean termite (Reticulitermes flavipes Kollar). Durability classifications were compared to their extractive contents, along with ATR-FTIR spectra of extracted and unextracted blocks to establish relationships using hierarchical cluster analysis (HCA) and principal component analysis (PCA). Western juniper durability varied with test organisms, but the majority of samples had high fungal and termite resistance. Moderate to weak connections were observed between durability and extractive content, but HCA and PCA analysis were unable to classify durability with accuracy. The absence of non-resistant samples may have influenced the ability of the chemometric methods to accurately categorize durability.
On the Use of Optimal Transportation Theory to Recode Variables and Application to Database Merging
Authors: Gares Valérie , Dimeglio Chloé , Guernec Grégory , Fantin Romain , Lepage Benoit , Kosorok Michael R. , Savy Nicolas 
Published: September 2019

Abstract
Merging databases is a strategy of paramount interest especially in medical research. A common problem in this context comes from a variable which is not coded on the same scale in both databases we aim to merge. This paper considers the problem of finding a relevant way to recode the variable in order to merge these two databases. To address this issue, an algorithm, based on optimal transportation theory, is proposed. Optimal transportation theory gives us an application to map the measure associated with the variable in database A to the measure associated with the same variable in database B. To do so, a cost function has to be introduced and an allocation rule has to be defined. Such a function and such a rule is proposed involving the information contained in the covariates. In this paper, the method is compared to multiple imputation by chained equations and a statistical learning method and has demonstrated a better average accuracy in many situations. Applications on both simulated and real datasets show that the efficiency of the proposed merging algorithm depends on how the covariates are linked with the variable of interest.
In vivo neuroprotective, antinociceptive, anti-inflammatory potential in Swiss albino mice and in vitro antioxidant and clot lysis activities of fractionated Holigarna longifolia Roxb. bark extract
Authors: Uddin Md. Zia , Rana Md. Sohel , Hossain Shahadat , Ferdous Sumaiya , Dutta Emon , Dutta Mycal , Emran Talha Bin 
Published: September 2019

Abstract

Background
The study investigated the in vivo neuroprotective, antinociceptive, anti-inflammatory potential and in vitro antioxidant and clot lysis activities of crude methanol extract with its different solvent-soluble fractions like petroleum ether (PESF), carbon tetrachloride (CTSF), chloroform (CSF) and aqueous (AQSF) of Holigarna longifolia Roxb.

Methods
Phenobarbitone-induced sleeping time method was used for the neuroprotective activity, writhing response experimental model introduced by acetic acid was designed for antinociceptive efficacy, carrageenan-induced paw edema model was carried out for anti-inflammatory activity, DPPH free radical scavenging activity was assessed for antioxidant activity and clot lysis model was investigated for the thrombolytic potential of the plant.

Results
On investigation it was found that methanol extract and CS fraction revealed statistically meaningful (p<0.05) neuroprotective activity by increasing phenobarbitone-induced sleeping time of mice, produced substantial (p<0.05) inflammation inhibitory efficacy compared to standard diclofenac sodium and also exhibited statistically significant (p<0.01) oxidative stress inhibitory efficacy by inhibiting free radical formation compared to ascorbic acid as standard. Only methanol extract produced significant (p<0.05) antinociceptive activity by inhibiting abdominal writhes produced by acetic acid compared to standard analgesic drug diclofenac sodium. And only aqueous soluble fraction exhibited moderate clot lysis activity compared to streptokinase as standard.

Conclusion
The findings demonstrate that H. longifolia could be potential neuroprotective due to its justified antioxidative capacity as well as clot lysis properties.
Beyond the color: the implications of pigmentation polymorphism in the activity behavior of a Neotropical squirrel
Authors: Tavares Mariana Silva , Aguiar Leonardo dos Santos , Salvador Carlos Henrique , Galliez Maron 
Published: September 2019

Abstract
Pigmentation polymorphism occurs in many mammals but is considered rare in natural populations. Here, we report the first record of pigmentation polymorphism in a Neotropical squirrel, Guerlinguetus ingrami, at a private reserve in southern Brazil. The number of records for leucistic squirrels was approximately half that for brown squirrels. We also tested the differences in activity patterns between the leucistic and the brown squirrels. Both phenotypes were diurnal, but there was temporal segregation between the two. Further studies are needed to elucidate the occurrence of leucism in G. ingrami, and the possible ecological and behavioral outcomes.
Spinozismus substanzloser Subjektivität. Jacobi und Jean Paul wider Fichtes Ichphilosophie
Authors: Wenz Gunther 
Published: September 2019

Zusammenfassung
Drei für Philosophie und Theologie gleichermaßen bedeutsame Streitigkeiten hat Friedrich Heinrich Jacobi (1743–1819) maßgeblich bestimmt: den sog. Pantheismusstreit um Spinoza und den angeblichen Spinozismus von Lessing, den sog. Atheismusstreit in Auseinandersetzung vor allem mit Fichte und den sog. Theismusstreit, der durch eine Kontroverse mit Schelling hervorgerufen wurde. Der vorliegende Beitrag ist auf den Atheismusstreit von 1799 konzentriert, an dem sich neben Jacobi auch sein Gefolgsmann Jean Paul beteiligte, um den Denker dichterisch zu unterstützen.
Infanticide in Adam Bede: Hetty Sorrel and the Language of Justice
Authors: D’Alfonso Francesca 
Published: September 2019

Abstract
Starting from an analysis of realism as expressed by George Eliot in Chapter 17 of Adam Bede, this paper intends to investigate the way in which law is enforced in a case of infanticide. In particular, in Eliot’s novel the crime is committed by the beautiful and naive Hetty Sorrel whose tragic destiny is a consequence of her seduction by the aristocratic Arthur Donnithorne. Hence her condition of a fallen woman and, accordingly, the trial culminating in the sentencing to hanging. Significantly, Hetty’s silence before the jury in the courtroom is interrupted thanks to the intervention of Dinah Morris, her Methodist cousin who, meeting the prisoner in solidarity and sympathy, will have from her a full confession of the events.
The Abstruse Syntax of Law in Wilkie Collins’s The Law and the Lady
Authors: Marroni Michela 
Published: September 2019

Abstract
From the point of view of the British juridical system, The Law and the Lady can be interpreted as a sensation novel whose crucial albeit indirect message must be read in the context of Collins’s legal reformism. As well as challenging the Scottish verdict of Not Proven, the heroine of the novel, Valeria Brinton, presents herself as a woman detective who is anxious to prove her husband’s innocence before both the court and public opinion. Underlining the peculiarity of her mission is a destabilising tension which, in its social implication, is aimed to challenge the conformism and love of orthodoxy typical of the Victorian ethos. In this sense, Valeria’s gendered autobiographical writing, while giving full evidence to her resourceful womanhood, dramatises the blurring of the confine between masculinity and femininity and, at the same time, offers a representation of the old-fashioned and abstruse protocols of British law.
Some Preliminary Evidence on China’s New Monetary Policy Tool: The Standing Lending Facility
Authors: Liu Kerry 
Published: September 2019

AbstractIn 2013, China’s central bank introduced the standing lending facility to manage the volatility of interbank market rates. This study is the first of its kind in the academic literature by examining the effect of this new monetary policy tool. Based on monthly data between December 2015–November 2018, the empirical results show that the standing lending facility operations can significantly reduce the volatility of overnight SHIBOR, an important policy rate in the Chinese financial markets.
La reescritura del maldit de Joan Roís de Corella
Authors: Martos Josep Lluís 
Published: September 2019

Abstract
The Maldit is Joan Roís de Corella’s only poem that appears in all of the manuscript witnesses of his poetry, which is a good indication of its literary success. This article reviews the variations of the poem throughout these manuscripts in order to focus on the process of rewriting, which reaches its maximum development in the version transmitted in the cancionero known as the Jardinet d’orats. The variants of all of the witnesses are discussed from ecdotic perspectives and the focus is on the double version of the tornada. The article demonstrates that the maldit is Joan Roís de Corella’s poem in which there is the greatest development and the greatest adherence to troubadouresque techniques. The person responsible for the version in the Jardinet d’orats does not notice these formal characteristics, which disappear in the process of rewriting, and this is the principal argument for considering it apocryphal. The literary character of the poem, like the Valencian environment in which it was produced, respond to a certain collectivity, which a different poet took advantage to generate the rewriting of Joan Roís de Corella’s maldit.
Holistic Problem of Cooling Effect of Vertically Oil-Quenched Shaft-Type Workpiece
Authors: Zhang Kejian , Wang Shui , Hao Xuezhi 
Published: September 2019

Abstract
During the process of vertical oil quenching, the sides of a shaft with the same effective thickness often do not obtain the same quench cooling effect. Therefore, the quench cooling effect of such workpieces can only be described with the distribution of measured values on the whole surface instead of measured values at individual spots. This is the holistic problem of the quenching effect of such workpieces. The main hazard caused by this type of holistic phenomenon is the creation of serious and regular uneven longitudinal quenching hardness, from inside out on the shaft. The holistic problem is caused by two factors: (1) the gas flow within the vapor blanket and (2) the order of the transition of vapor blanket to nucleate boiling on the surface of the workpiece. Through experimental observation, analysis, and inference, a general model is summarized for the holistic problem of workpieces with shafts of different lengths in the quenching process. By using the general model and the law disclosed by it, a new technique is developed to solve the holistic problem of the workpieces. With the new technique, higher and more uniform quenching hardness can be achieved, the quenching period of the workpiece can be shortened substantially, and steels with lower hardenability can be used to make the workpieces and achieve the same hardening effect. Moreover, oil quenching can replace induction quenching and achieve the same case hardening effect. By comparing the characteristics of the holistic problem and the distortion problem of workpieces in quenching, we arrived at two inferences: (1) quenching distortion and the holistic phenomenon have the same driving factors and (2) quenching distortion is just one of the detriments caused by the holistic problem. Therefore, the quenching distortion problem of most workpieces can be solved by the angle of their holistic problems.
RIMB-1/RIM-Binding Protein and UNC-10/RIM Redundantly Regulate Presynaptic Localization of the Voltage-Gated Calcium Channel inCaenorhabditis elegans
Authors: Kushibiki Yuto , Suzuki Toshiharu , Jin Yishi , Taru Hidenori 
Published: September 2019

Presynaptic active zones (AZs) contain many molecules essential for neurotransmitter release and are assembled in a highly organized manner. A network of adaptor proteins known as cytomatrix at the AZ (CAZ) is important for shaping the structural characteristics of AZ. Rab3-interacting molecule (RIM)-binding protein (RBP) family are binding partners of the CAZ protein RIM and also bind the voltage-gated calcium channels (VGCCs) in mice and flies. Here, we investigated the physiological roles of RIMB-1, the homolog of RBPs in the nematodeCaenorhabditis elegans. RIMB-1 is expressed broadly in neurons and predominantly localized at presynaptic sites. Loss-of-function animals ofrimb-1displayed slight defects in motility and response to pharmacological inhibition of synaptic transmission, suggesting a modest involvement ofrimb-1in synapse function. We analyzed genetic interactions ofrimb-1by testing candidate genes and by an unbiased forward genetic screen forrimb-1enhancer. Both analyses identified the RIM homolog UNC-10 that acts together with RIMB-1 to regulate presynaptic localization of the P/Q-type VGCC UNC-2/Cav2. We also find that the precise localization of RIMB-1 to presynaptic sites requires presynaptic UNC-2/Cav2. RIMB-1 has multiple FN3 and SH3 domains. Our transgenic rescue analysis with RIMB-1 deletion constructs revealed a functional requirement of a C-terminal SH3 in regulating UNC-2/Cav2 localization. Together, these findings suggest a redundant role of RIMB-1/RBP and UNC-10/RIM to regulate the abundance of UNC-2/Cav2 at the presynaptic AZ inC. elegans, depending on the bidirectional interplay between CAZ adaptor and channel proteins.SIGNIFICANCE STATEMENTPresynaptic active zones (AZs) are highly organized structures for synaptic transmission with characteristic networks of adaptor proteins called cytomatrix at the AZ (CAZ). In this study, we characterized a CAZ protein RIMB-1, named for RIM-binding protein (RBP), in the nematodeCaenorhabditis elegans. Through systematic analyses of genetic interactions and an unbiased genetic enhancer screen ofrimb-1, we revealed a redundant role of two CAZ proteins RIMB-1/RBP and UNC-10/RIM in regulating presynaptic localization of UNC-2/Cav2, a voltage-gated calcium channel (VGCC) critical for proper neurotransmitter release. Additionally, the precise localization of RIMB-1/RBP requires presynaptic UNC-2/Cav2. These findings provide new mechanistic insight about how the interplay among multiple CAZ adaptor proteins and VGCC contributes to the organization of presynaptic AZ.
Pendidikan Kewarganegaraan Mengusung Pancasila sebagai Konsensus Sosial, Kontrak Sosial, dan Social Imaginary
Authors: Laksono Leonard Bayu 
Published: September 2019

The regulations on Higher Education are taught simultaneously two courses which intersect with each other, namely Pancasila and Citizenship education. The two learning contents of these courses can also be harmonized to achieve general learning objectives, especially related to the participation of citizens in the midst of national and state life, to build a civilization based on Pancasila values. This paper presents a critical note developed from historical-sociological content to see the realm of citizenship education in the context of the Republic of Indonesia, particularly highlighted from the perspective of social consensus theory, social contracts, and social imaginary. These three things then lead to the prioritization of the religious communities in their participation as part of civil society, and which have struggled from the beginning in the establishment of the state and its constitution. The awareness and participation of the religious communities is the idea of citizenship in the context of a pluralistic and multicultural society.Â Pada peraturan tentang Pendidikan Tinggi diajarkan secara bersamaan dua mata kuliah yang saling beririsan satu dengan yang lain, yaitu pendidikan Pancasila dan Kewarganegaraan. Kedua isi pembelajaran mata kuliah-mata kuliah tersebut dapat pula diselaraskan untuk mencapai tujuan pembelajaran secara umum, terutama terkait dengan peran serta warga negara dalam berpartisipasi di tengah-tengah kehidupan berbangsa dan bernegara, untuk membangun peradaban berdasarkan nilai-nilai Pancasila. Tulisan ini menyuguhkan catatan kritis yang dikembangkan dari muatan-muatan historis-sosiologis untuk melihat ranah pendidikan kewarganegaraan dalam konteks negara Republik Indonesia ini, terutama disorot dari perspektif teori konsensus sosial, kontrak sosial, dan social imaginary. Ketiga hal tersebut kemudian mengarahkan pada pengutamaan komunitas agama-agama dalam peran sertanya sebagai bagian dari masyarakat sipil madani (civil society), dan yang telah bergumul sejak semula dalam pendirian negara dan konstitusinya. Kesadaran dan partisipasi komunitas agama-agama inilah yang menjadi gagasan kewarganegaran (citizenship) di tengah konteks masyarakat majemuk dan multikultural.