bluuebunny/crossref_metadata_2025_split huggingface dataset:
Guided or self-guided internet-based cognitive–behavioural therapy (iCBT) for depression? Study protocol of an individual participant data network meta-analysis
Authors: Karyotaki Eirini , Furukawa Toshi A , Efthimiou Orestis , Riper Heleen , Cuijpers Pim 
Published: June 2019

IntroductionAlthough guided forms of internet-based cognitive–behavioural therapy (iCBT) result in a substantial reduction in depression, it seems that the most scalable way to deliver iCBT is without guidance. However, direct evidence on the comparison between guided and self-guided iCBT is scarce. Moreover, it is unclear which types of patients may benefit more from each of these two forms of iCBT. Network meta-analysis (NMA) using individual participant data (IPD) offers a way to assess the relative efficacy of multiple (>2) interventions. Moreover, it maximises our power to detect patient-level characteristics (covariates) that have an important effect on the efficacy of interventions. This protocol describes the procedures of an IPD-NMA, which aims at examining the relative efficacy of guided compared with self-guided iCBT and at identifying predictors and moderators of treatment outcome.Methods and analysisWe will use an existing database on psychotherapies for adult depression to identify eligible studies. This database has been updated up to 1 January 2018, through literature searches in PubMed, Embase, PsycINFO and Cochrane Library. The outcome of this IPD-NMA is reduction in depressive symptoms severity. We will fit the model in a Bayesian setting. After fitting the model, we will report the relative treatment effects for different types of patients, and we will discuss the clinical implications of our findings. Based on the results from the IPD-NMA model, we will develop and validate a personalised prediction model, aiming to provide patient-level predictions about the effects of the interventions.Ethics and disseminationAn ethical approval is not required for this study. The results will be published in a peer-review journal. These results will guide clinical decisions about the most efficient way to allocate iCBT resources, thereby increasing the scalability of this innovative therapeutic approach.
Association between continuity of provider-adjusted regularity of general practitioner contact and unplanned diabetes-related hospitalisation: a data linkage study in New South Wales, Australia, using the 45 and Up Study cohort
Authors: Moorin Rachael E , Youens David , Preen David B , Harris Mark , Wright Cameron M 
Published: June 2019

ObjectiveTo assess the association between continuity of provider-adjusted regularity of general practitioner (GP) contact and unplanned diabetes-related hospitalisation or emergency department (ED) presentation.DesignCross-sectional study.SettingIndividual-level linked self-report and administrative health service data from New South Wales, Australia.Participants27 409 survey respondents aged ≥45 years with a prior history of diabetes and at least three GP contacts between 1 July 2009 and 30 June 2015.Main outcome measuresUnplanned diabetes-related hospitalisations or ED presentations, associated costs and bed days.ResultsTwenty-one per cent of respondents had an unplanned diabetes-related hospitalisation or ED presentation. Increasing regularity of GP contact was associated with a lower probability of hospitalisation or ED presentation (19.9% for highest quintile, 23.5% for the lowest quintile). Conditional on having an event, there was a small decrease in the number of hospitalisations or ED presentations for the low (−6%) and moderate regularity quintiles (−8%), a reduction in bed days (ranging from −30 to −44%) and a reduction in average cost of between −23% and −41%, all relative to the lowest quintile. When probability of diabetes-related hospitalisation or ED presentation was included, only the inverse association with cost remained significant (mean of $A3798 to $A6350 less per individual, compared with the lowest regularity quintile). Importantly, continuity of provider did not significantly modify the effect of GP regularity for any outcome.ConclusionsHigher regularity of GP contact—that is more evenly dispersed, not necessarily more frequent care—has the potential to reduce secondary healthcare costs and, conditional on having an event, the time spent in hospital, irrespective of continuity of provider. These findings argue for the advocacy of regular care, as distinct from solely continuity of provider, when designing policy and financial incentives for GP-led primary care.
Missed nursing care in newborn units: a cross-sectional direct observational study
Authors: Gathara David , Serem George , Murphy Georgina A V , Obengo Alfred , Tallam Edna , Jackson Debra , Brownie Sharon , English Mike 
Published: June 2019

BackgroundImproved hospital care is needed to reduce newborn mortality in low/middle-income countries (LMIC). Nurses are essential to the delivery of safe and effective care, but nurse shortages and high patient workloads may result in missed care. We aimed to examine nursing care delivered to sick newborns and identify missed care using direct observational methods.MethodsA cross-sectional study using direct-observational methods for 216 newborns admitted in six health facilities in Nairobi, Kenya, was used to determine which tasks were completed. We report the frequency of tasks done and develop a nursing care index (NCI), an unweighted summary score of nursing tasks done for each baby, to explore how task completion is related to organisational and newborn characteristics.ResultsNursing tasks most commonly completed were handing over between shifts (97%), checking and where necessary changing diapers (96%). Tasks with lowest completion rates included nursing review of newborns (38%) and assessment of babies on phototherapy (15%). Overall the mean NCI was 60% (95% CI 58% to 62%), at least 80% of tasks were completed for only 14% of babies. Private sector facilities had a median ratio of babies to nurses of 3, with a maximum of 7 babies per nurse. In the public sector, the median ratio was 19 babies and a maximum exceeding 25 babies per nurse. In exploratory multivariable analyses, ratios of ≥12 babies per nurse were associated with a 24-point reduction in the mean NCI compared with ratios of ≤3 babies per nurse.ConclusionA significant proportion of nursing care is missed with potentially serious effects on patient safety and outcomes in this LMIC setting. Given that nurses caring for fewer babies on average performed more of the expected tasks, addressing nursing is key to ensuring delivery of essential aspects of care as part of improving quality and safety.
Multiplex profiling of peritoneal metastases from gastric adenocarcinoma identified novel targets and molecular subtypes that predict treatment response
Authors: Wang Ruiping , Song Shumei , Harada Kazuto , Ghazanfari Amlashi Fatemeh , Badgwell Brian , Pizzi Melissa Pool , Xu Yan , Zhao Wei , Dong Xiaochuan , Jin Jiangkang , Wang Ying , Scott Ailing , Ma Lang , Huo Longfei , Vicente Diego , Blum Murphy Mariela , Shanbhag Namita , Tatlonghari Ghia , Thomas Irene , Rogers Jane , Kobayashi Makoto , Vykoukal Jody , Estrella Jeannelyn Santiano , Roy-Chowdhuri Sinchita , Han Guangchun , Zhang Shaojun , Mao Xizeng , Song Xingzhi , Zhang Jianhua , Gu Jian , Johnson Randy L , Calin George Adrian , Peng Guang , Lee Ju-Seog , Hanash Samir M , Futreal Andrew , Wang Zhenning , Wang Linghua , Ajani Jaffer A 
Published: June 2019

ObjectivePeritoneal carcinomatosis (PC) occurs frequently in patients with gastric adenocarcinoma (GAC) and confers a poor prognosis. Multiplex profiling of primary GACs has been insightful but the underpinnings of PC’s development/progression remain largely unknown. We characterised exome/transcriptome/immune landscapes of PC cells from patients with GAC aiming to identify novel therapeutic targets.DesignWe performed whole-exome sequencing (WES) and whole transcriptome sequencing (RNA-seq) on 44 PC specimens (43 patients with PC) including an integrative analysis of WES, RNA-seq, immune profile, clinical and pathological phenotypes to dissect the molecular pathogenesis, identifying actionable targets and/or biomarkers and comparison with TCGA primary GACs.ResultsWe identified distinct alterations in PC versus primary GACs, such as more frequentCDH1 and TAF1mutations, 6q loss and chr19 gain. Alterations associated with aggressive PC phenotypes emerged with increased mutations inTP53, CDH1, TAF1andKMT2C, higher level of ‘clock-like’ mutational signature, increase in whole-genome doublings, chromosomal instability (particularly, copy number losses), reprogrammed microenvironment, enriched cell cycle pathways, MYC activation and impaired immune response. Integrated analysis identified two main molecular subtypes: ‘mesenchymal-like’ and ‘epithelial-like’ with discriminating response to chemotherapy (31% vs 71%). Patients with the less responsive ‘mesenchymal-like’ subtype had high expression of immune checkpoint T-Cell Immunoglobulin And Mucin Domain-Containing Protein 3 (TIM-3), its ligand galectin-9, V-domain Ig suppressor of T cell activation (VISTA) and transforming growth factor-β as potential therapeutic immune targets.ConclusionsWe have uncovered the unique mutational landscape, copy number alteration and gene expression profile of PC cells and defined PC molecular subtypes, which correlated with PC therapy resistance/response. Novel targets and immune checkpoint proteins have been identified with a potential to be translated into clinics.
Cor triatriatum sinistrum diagnosed in the adulthood: a systematic review
Authors: Rudienė Virginija , Hjortshøj Cristel M S , Glaveckaitė Sigita , Zakarkaitė Diana , Petrulionienė Žaneta , Gumbienė Lina , Aidietis Audrius , Søndergaard Lars 
Published: June 2019

BackgroundWe performed a systematic review of cor triatriatum sinistrum (CTS) diagnosed in adults. The aim of this review was to describe the clinical presentation, natural history and management of this congenital heart disease.MethodsA PubMed literature search for ‘cor triatriatum sinistrum’ published since 2005 was performed. Included patients were divided into those with and without obstructive membrane physiology. The clinical course differences were compared.ResultsA total of 171 published cases were included. The median age at diagnosis was 43 years (IQR, 30–60). Obstructive membrane physiology was observed in 70 (41%), and this patient group was younger at presentation (median age 39 (IQR, 28–52) vs 50 years (IQR, 32–64), p=0.003).Patients with obstructive membrane more frequently had associated cardiac defects (58.6% vs 42.4%, p=0.039). Overall, the most frequent clinical symptom was atrial fibrillation, as this was present in 56 (32.8%) of all patients. CTS-related symptoms were more frequent in patients with obstructive membrane: congestive heart failure (44.3% vs 15.2%, p<0.001), pulmonary hypertension (27.1% vs 6.1%, p<0.001), haemorrhage (8.6% vs 0%, p=0.004) and infections manifestation (8.6% vs 0%, p=0.004).A total of 71 (41.5%) patients with CTS required interventional treatment, mainly within patients with the obstructive membrane (86.8% vs 12.6%, p<0.001).ConclusionThe natural history of CTS most often manifests with symptoms of congestive heart failure. Patients with obstructive membrane most often have associated cardiac defects and higher risk for infections and haemorrhage. The interventional treatment of CTS remains the first choice for obstructive membrane.
Calcification and extracellular matrix dysregulation in human postmortem and surgical aortic valves
Authors: Gomez-Stallons M Victoria , Tretter Justin T , Hassel Keira , Gonzalez-Ramos Osniel , Amofa Dorothy , Ollberding Nicholas J , Mazur Wojciech , Choo Joseph K , Smith J Michael , Kereiakes Dean J , Yutzey Katherine E 
Published: June 2019

ObjectivesCalcific aortic valve disease (CAVD) is a progressive disease ranging from aortic valve (AoV) sclerosis to AoV stenosis (AS), characterised by severe calcification with impaired leaflet function. Due to the lack of early symptoms, the pathological progression towards valve dysfunction is poorly understood. The early patterns of AoV calcification and altered extracellular matrix (ECM) organisation were analysed in individuals postmortem without clinical AS compared with clinical AS.MethodsHistological patterns of calcification and ECM organisation in postmortem AoV leaflets without clinical AS obtained from a tissue repository and surgical specimens obtained from individuals with clinical AS were compared with in vivo imaging prior to transcatheter AoV implantation.ResultsAoV calcification was detected in all samples from individuals >50 years old, with severity increasing with age, independent of known CAVD risk factors. Two distinct types of calcification were identified: ‘Intrinsic’, primarily found at the leaflet hinge of postmortem leaflets, accompanied by abnormal collagen and proteoglycan deposition; and ‘Nodular’, extending from the middle to the tip regions in more severely affected postmortem leaflets and surgical specimens, associated with increased elastin fragmentation and loss of elastin integrity. Even in the absence of increased thickening, abnormalities in ECM composition were observed in postmortem leaflets without clinical AS and worsen in clinical AS.ConclusionsTwo distinct phenotypes of AoV calcification are apparent. While the ‘nodular’ form is recognised on in vivo imaging and is present with CAVD and valve dysfunction, it is unclear if the ‘intrinsic’ form is pathological or detected on in vivo imaging.
Interactive Mapping Specification with Exemplar Tuples
Authors: Bonifati Angela , Comignani Ugo , Coquery Emmanuel , Thion Romuald 
Published: June 2019

While schema mapping specification is a cumbersome task for data curation specialists, it becomes unfeasible for non-expert users, who are unacquainted with the semantics and languages of the involved transformations.
In this article, we present an interactive framework for schema mapping specification suited for non-expert users. The underlying key intuition is to leverage a few exemplar tuples to infer the underlying mappings and iterate the inference process via simple user interactions under the form of Boolean queries on the validity of the initial exemplar tuples. The approaches available so far are mainly assuming pairs of complete universal data examples, which can be solely provided by data curation experts, or are limited to poorly expressive mappings.
We present a quasi-lattice-based exploration of the space of all possible mappings that satisfy arbitrary user exemplar tuples. Along the exploration, we challenge the user to retain the mappings that fit the user’s requirements at best and to dynamically prune the exploration space, thus reducing the number of user interactions. We prove that after the refinement process, the obtained mappings are correct and complete. We present an extensive experimental analysis devoted to measure the feasibility of our interactive mapping strategies and the inherent quality of the obtained mappings.
Clinical and Antitumor Immune Responses in Relapsed/Refractory Follicular Lymphoma Patients after Intranodal Injections of IFNα-Dendritic Cells and Rituximab: a Phase I Clinical Trial
Authors: Cox M. Christina , Castiello Luciano , Mattei Mauro , Santodonato Laura , D'Agostino Giuseppina , Muraro Elena , Martorelli Debora , Lapenta Caterina , Di Napoli Arianna , Di Landro Francesca , Cangemi Michela , Pavan Antonio , Castaldo Paolo , Hohaus Stefan , Donati Simona , Montefiore Enrica , Berdini Cinzia , Carlei Davide , Monque Domenica M. , Ruco Luigi , Prosperi Daniela , Tafuri Agostino , Spadaro Francesca , Sestili Paola , Spada Massimo , Dolcetti Riccardo , Santini Stefano M. , Rozera Carmela , Aricò Eleonora , Capone Imerio , Belardelli Filippo 
Published: June 2019

Abstract

Purpose:
This study was aimed at evaluating the feasibility, safety, immunologic and clinical responses in patients with follicular lymphoma treated with monocyte-derived dendritic cells generated in the presence of IFNα and GM-CSF (IFN-DC) in combination with low doses of rituximab.

Patients and Methods:
Firstly, we analyzed in vitro and in vivo the immunologic properties of IFN-DC against follicular lymphoma. Thus, we performed a phase I trial in 8 patients with refractory and relapsed follicular lymphoma based on sequential intranodal injections of low-dose of rituximab and unloaded IFN-DC and report the safety, clinical, and immunologic results of the enrolled patients.

Results:
Preclinical studies indicated that IFN-DC can synergize with rituximab leading to increased cytotoxicity and T-cell tumor infiltration. The clinical evaluation showed that the combined treatment was totally safe. The overall response rate was 50%, PET-negative complete response rate 37%, and remission is still ongoing in 2/4 of responding patients (median follow-up 26 months, range 11–47). Notably, following the combined therapy all patients showed induction/enhancement of T-cell responses by CD107 degranulation or IFNγ ELISPOT assay against patient-specific tumor IGHV sequences.

Conclusions:
These results represent the proof-of-principle on the effectiveness of unloaded IFN-DC in inducing durable clinical responses and promoting induction of tumor-specific peripheral T cells, thus suggesting the occurrence of an effective endogenous antitumor vaccination. The overall findings indicate that some unique properties of IFN-DC can be successfully exploited to induce/enhance antitumor responses, thus representing a valuable antitumor strategy for novel and more effective combination therapies in patients with cancer.
Vessel Wall Imaging of Evolving Unruptured Intracranial Aneurysms
Authors: Matsushige Toshinori , Shimonaga Koji , Ishii Daizo , Sakamoto Shigeyuki , Hosogai Masahiro , Hashimoto Yukishige , Kaneko Mayumi , Ono Chiaki , Mizoue Tatsuya , Kurisu Kaoru 
Published: June 2019

Background and Purpose—
Unruptured intracranial aneurysms (UIAs) have various scenarios of growth and rupture. Magnetic resonance vessel wall imaging can detect aneurysmal wall thickening with inflammation and neovascularization. This study was performed to explore the vessel wall imaging findings of UIAs with consecutive follow-up.

Methods—
A total of 60 aneurysms with serial angiography over 2 years (mean period, 49 months, range, 24–192 months) were evaluated by vessel wall imaging. UIAs were morphologically categorized into 3 patterns: stable, whole sac expansion, or daughter sac formation. Aneurysm wall enhancement (AWE) was evaluated after administration of gadolinium.

Results—

Thirty-three of the 60 UIAs (55%) demonstrated no morphological changes, whereas 16 UIAS (27%) showed whole sac expansion and 11 UIAs (18%) demonstrated daughter sac formation. AWE was significantly less frequent in stable UIAs compared with UIAs showing morphological changes (
P
<0.01). Aneurysms with daughter sac formation showed a significantly higher frequency of AWE than those demonstrating whole sac expansion. In the majority of UIAs with daughter sac formation, AWE was detected in the main aneurysm and not in the developing component.

Conclusions—
UIAs demonstrate various modes of growth. The pattern of AWE might be useful for identifying unfavorable morphological changes of UIAs.
Differential patterns of vocal similarity in tolerant and intolerant macaques
Authors: De Marco Arianna , Rebout Nancy , Massiot Elodie , Sanna Andrea , Sterck Elisabeth H.M. , Langermans Jan A.M. , Cozzolino Roberto , Thierry Bernard , Lemasson Alban 
Published: June 2019

Abstract
The investigation of vocal similarity between individuals has provided evidence of the flexibility of communication signals. This study evaluates the impact of group membership, affiliative bonds, kinship and dominance on acoustic similarity in two primate species with different social styles, intolerant rhesus macaques and tolerant Tonkean macaques. We focused on the fundamental frequencies of the contact calls emitted by adult females. Close kinship promoted vocal similarity between individuals in both species, and also group membership in Tonkean macaques, indicating the involvement of experiential and/or genetic factors. In rhesus macaques more similarities were observed between partners with strong or weak dominance asymmetry than between those with medium asymmetry, which again points to the role of experience. No evidence was found that dominance influences vocal similarity in Tonkean macaques. Our results provide additional evidence to the flexibility of vocal signals produced by macaques, and reveal that it is influenced by social style.
Taxonomy of deep-sea shrimps of the Superfamily Oplophoroidea Dana 1852 (Decapoda: Caridea) from Southwestern Atlantic
Authors: ALVES-JÚNIOR FLAVIO DE ALMEIDA , SILVA ELINAI DOS SANTOS , DE ARAÚJO MARINA DE SÁ LEITÃO CÂMARA , CARDOSO IRENE , BERTRAND ARNAUD , SOUZA-FILHO JESSER F. 
Published: June 2019

In this paper, we provide some available information about the occurrence and some taxonomic aspects of 19 species from the Superfamily Oplophoroidea in the southwestern Atlantic (Brazilian waters), with the update to 22 species of Oplophoroidea occurring in Brazilian waters. Samples were collected during two sets of surveys. The first was performed in 2009 and 2011 in the Potiguar Basin in northeast of Brazil (03–05°S; 38–35°W; between the States of Ceará and Rio Grande do Norte) under the framework of the project “Avaliação da biota bentônica e planctônica da Bacia Potiguar e Ceará (Bpot)”, with samples collected from bottom trawls in the continental slope at depth ranging from 150–2068 m. Second, under the in the framework of the ABRACOS (Acoustic along the Brazilian coast), performed in 2015 and 2017 on seamounts and offshore areas in Northeast Brazil (Ceará Chain, Rio Grande do Norte and Rocas Atoll, Fernando de Noronha Archipelago and Pernambuco State), with samples with pelagic micronekton and mesopelagic nets, in depths ranging from 50–1260 m. We highlight the occurrence of 14 species of the family Acanthephyridae and 5 species of the family Oplophoridae, including the first occurrences of five species to Brazilian deep waters: Acanthephyra kingsleyi Spence Bate, 1888, Ephyrina ombango Crosnier & Forest, 1973, Meningodora compsa (Chace, 1940), M. longisulca Kikuchi, 1985 and Systellapsis curvispina Crosnier, 1987. These records increase the knowledge on deep-sea shrimps occurring in Southwestern Atlantic.