bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase III Trial of PROSTVAC in Asymptomatic or Minimally Symptomatic Metastatic Castration-Resistant Prostate Cancer
Authors: Gulley James L. , Borre Michael , Vogelzang Nicholas J. , Ng Siobhan , Agarwal Neeraj , Parker Chris C. , Pook David W. , Rathenborg Per , Flaig Thomas W. , Carles Joan , Saad Fred , Shore Neal D. , Chen Liddy , Heery Christopher R. , Gerritsen Winald R. , Priou Frank , Langkilde Niels C. , Novikov Andrey , Kantoff Philip W. 
Published: February 2019

PURPOSE PROSTVAC, a viral vector–based immunotherapy, prolonged median overall survival (OS) by 8.5 months versus placebo in metastatic castration-resistant prostate cancer in a phase II study. This phase III study further investigated those findings. PATIENTS AND METHODS Patients were randomly assigned to PROSTVAC (Arm V; n = 432), PROSTVAC plus granulocyte-macrophage colony-stimulating factor (Arm VG; n = 432), or placebo (Arm P; n = 433), stratified by prostate-specific antigen (less than 50 ng/mL v 50 ng/mL or more) and lactate dehydrogenase (less than 200 v 200 U/L or more). Primary end point was OS. Secondary end points were patients alive without events (AWE)—namely, radiographic progression, pain progression, chemotherapy initiation, or death—at 6 months and safety. The study design was a superiority trial of PROSTVAC (Arm V or Arm VG) versus Arm P. Three interim analyses were planned. RESULTS At the third interim analysis, criteria for futility were met and the trial was stopped early. Neither active treatment had an effect on median OS (Arm V, 34.4 months; hazard ratio, 1.01; 95% CI, 0.84 to 1.20; P = .47; Arm VG, 33.2 months; hazard ratio, 1.02; 95% CI, 0.86 to 1.22; P = .59; Arm P, 34.3 months). Likewise, AWE at 6 months was similar (Arm V, 29.4%; odds ratio, 0.96; 95% CI, 0.71 to 1.29; Arm VG, 28.0%; odds ratio, 0.89; 95% CI, 0.66 to 1.20; placebo, 30.3%). Adverse events were similar for the treatment and placebo groups, with the most common being injection site reactions (62% to 72%) and fatigue (21% to 24%). Arrhythmias were the most common cardiac-related events (1.4% to 3.5%). There were no reports of either myocarditis or pericarditis. Serious treatment-related events occurred in less than 1% of all patients. CONCLUSION Whereas PROSTVAC was safe and well tolerated, it had no effect on OS or AWE in metastatic castration-resistant prostate cancer. Combination therapy is currently being explored in clinical trials.
Does Household Finance Matter? Small Financial Errors with Large Social Costs
Authors: Bhamra Harjoat S. , Uppal Raman 
Published: February 2019

Households with familiarity biases tilt their portfolios toward a few risky assets. The resulting mean-variance loss from portfolio underdiversification is equivalent to only a modest reduction of about 1 percent per year in a household’s portfolio return. However, once we consider also the effect of familiarity biases on the asset- allocation and intertemporal consumption-savings decisions, the welfare loss is multiplied by a factor of four. In general equilibrium, the suboptimal decisions of households distort also aggregate growth, amplifying further the overall social welfare loss. Our findings demonstrate that financial markets are not a mere sideshow to the real economy and that improving the financial decisions of households can lead to large benefits, not just for individual households, but also for society. (JEL D14, D91, E21, E44, G11, G41)
Shear wave elastography for the diagnosis of small (≤2 cm) breast lesions: added value and factors associated with false results
Authors: Choi Hye Young , Seo Mirinae , Sohn Yu-Mee , Hwang Ji Hye , Song Eun Jee , Min Sun Young , Kang Hye Jin , Han Dong Yoon 
Published: February 2019

Objective:
We compared the diagnostic performance of B-mode ultrasound, shear wave elastography (SWE), and combined B-mode ultrasound and SWE in small breast lesions (≤ 2 cm), and evaluated the factors associated with false SWE results.

Methods:
A total of 428 small breast lesions (≤ 2 cm) of 415 consecutive patients between August 2013 and February 2017 were included. The diagnostic performance of each set was evaluated using the area under the receiver operating characteristic curve (AUC) analysis. Histologic diagnosis was used as reference standard. Multivariate logistic regression analyses identified the factors associated with false SWE results.

Results:
Of 428 lesions, 142 (33.2%) were malignant and 286 (66.8%) were benign. The AUC of the combined modality was higher than that of B-mode ultrasound (0.792 vs 0.572, p &lt; 0.001) and that of SWE was higher than that of B-mode ultrasound (0.718 vs 0.572, p &lt; 0.001). Multivariate analysis showed that the smaller lesion size and in situ cancer were associated with false negative, and patient’s age, high-risk lesion, shorter distance from the skin or chest wall, and deeper breast thickness were associated with false positive (all p &lt; 0.05).

Conclusions:
The addition of SWE to B-mode ultrasound could improve the diagnostic performance in ≤ 2 cm lesions. However, ultrasound lesion size, pathology, and lesion location are likely to affect the SWE value and result in false results.

Advances in knowledge:
Despite the diagnostic usefulness of SWE in small breast lesions (≤ 2 cm), ultrasound lesion size, pathology, and lesion location were associated with false results.
Gestão e saúde em simbiose
Authors: Tonelli Maria José , Wilner Adriana 
Published: February 2019

Nessa primeira edição de 2019, queremos agradecer nossos autores e leitores pela frutífera parceria no ano que passou. Esperamos continuar com o apoio de todos no ciclo que se inicia.Ao celebrar a entrada de um novo ano, pedimos sempre “saúde para dar e vender”. Ésobre esse tema que versam os artigos do Caderno Especial desta edição. Não temos muitoa comemorar, infelizmente. A definição da Organização Mundial da Saúde (OMS) dizque “saúde é um estado de completo bem-estar físico, mental e social”. Parece que estamoslonge de alcançar o que essa definição nos propõe. Para que esse ideal seja alcançado, a saúde precisa cada vez mais da gestão, assim como vice-versa.
Characteristics of successful integrated family planning and maternal and child health services: Findings from a mixed-method, descriptive evaluation
Authors: Pfitzer Anne , Maly Christina , Tappis Hannah , Kabue Mark , Mackenzie Devon , Healy Sadie , Srivastava Vineet , Ndirangu Gathari 
Published: February 2019

Background: Most postpartum women in low- and middle-income countries want to delay or avoid future pregnancies but are not using modern contraception. One promising strategy for increasing the use of postpartum family planning (PPFP) is integration with maternal, newborn and child health (MNCH) services. However, there is limited evidence on effective service integration strategies. We examine facilitators of and barriers to effective PPFP integration in MNCH services in Kenya and India. Methods: We conducted a cross-sectional, mixed-method study in two counties in Kenya and two states in India. Data collection included surveying 215 MNCH clients and surveying or interviewing 82 health care providers and managers in 15 health facilities across the four sites. We analyzed data from each country separately. First, we analyzed quantitative data to assess the extent to which PPFP was integrated within MNCH services at each facility. Then we analyzed qualitative data and synthesized findings from both data sources to identify characteristics of well and poorly integrated facilities. Results: PPFP integration success varied by service delivery area, health facility, and country. Issues influencing the extent of integration included availability of physical space for PPFP services, health workforce composition and capacity, family planning commodities availability, duration and nature of support provided. Conclusions: Although integration level varied between health facilities, factors enabling and hindering PPFP integration were similar in India and Kenya. Better measures are needed to verify whether services are integrated as prescribed by national policies.
Sensory-motor impairments of ipsilesional extremities and its impact on activity limitations following stroke
Authors: Savant Divyarani , Telang Vimal 
Published: February 2019

Background/Aims Stroke can result in various motor and sensory impairments on contralesional as well as ipsilesional limbs. This study examined the impact on activity limitations as a result of sensory and motor impairments of ipsilesional limbs following stroke. Methods A cross-sectional study was used to assess 50 adults with stroke (acute: n=6, subacute: n=10, chronic: n=34) and 50 age- and gender-matched typically healthy adults. The Modified Ashworth Scale, the Brunnstrom Approach, Nottingham Sensory Assessment, Star Cancellation Test, Right-Left Orientation Test, Trunk Impairment Scale, Single Leg Stance Test, and the Fugl Mayer Assessment were used to measure outcomes for ipsilesional side impairments. Activity limitations were scored using the Wisconsin Gait Scale and the Motor Assessment Scale. Results A comparison of all impairments: tonal, voluntary control, sensation, perception, sitting and standing balance, and coordination of the ipsilesional extremity of persons with hemiparesis with corresponding extremity of typically healthy adults using unpaired t-test, showed significant impairment (P<0.05). Every participant with stroke had at least one impairment on their ipsilesional side, with 8% of participants having only one impairment, 36% had two impairments, 28% had three impairments, 18% had four impairments, 8% had five impairments and 2% had all six impairments on their ipsilesional side. The percentage of participants with stroke presenting with trunk impairment was highest (100%) and that of voluntary control impairment was lowest (24%) on their ipsilesional side. The relationship between identified impairments and activity limitations was calculated using Pearson’s correlation at 0.05 level, which showed a moderate negative correlation with the Wisconsin Gait Scale and a moderate positive correlation with the Motor Assessment Scale. Conclusions Ipsilesional impairments present in people with hemiparesis have a significant impact on the activity limitation; hence it is necessary to address ipsilesional impairments along with contralesional impairments.
Femoral morphology asymmetry in hip dysplasia makes radiological leg length measurement inaccurate
Authors: Tamura K. , Takao M. , Hamada H. , Ando W. , Sakai T. , Sugano N. 
Published: February 2019

Aims The aim of this study was to examine whether hips with unilateral osteoarthritis (OA) secondary to developmental dysplasia of the hip (DDH) have significant asymmetry in femoral length, and to determine potential related factors. Patients and Methods We enrolled 90 patients (82 female, eight male) with DDH showing unilateral OA changes, and 43 healthy volunteers (26 female, 17 male) as controls. The mean age was 61.8 years (39 to 93) for the DDH groups, and 71.2 years (57 to 84) for the control group. Using a CT-based coordinate measurement system, we evaluated the following vertical distances: top of the greater trochanter to the knee centre (femoral length GT), most medial prominence of the lesser trochanter to the knee centre (femoral length LT), and top of the greater trochanter to the medial prominence of the lesser trochanter (intertrochanteric distance), along with assessments of femoral neck anteversion and neck shaft angle. Results The percentages of hips with an absolute difference of > 5 mm in femoral GT and LT lengths were significantly larger in the DDH group (24% for both) compared with those of the control group (2% and 7%, respectively). The femoral length GT of the affected femur was significantly shorter in Crowe I and longer in Crowe IV than that of the unaffected side. The affected-to-unaffected difference of the intertrochanteric distance showed positive correlation with that of the femoral length GT in Crowe I and Crowe II/III, and negative correlation with that of the femoral length LT in the Crowe I and Crowe IV groups. Conclusion Hips with unilateral end-stage OA secondary to DDH show significant asymmetry in femoral length between both the greater and lesser trochanter and the knee compared with controls. The intertrochanteric distance was a morphological factor related to femoral-length asymmetry. When undertaking total hip arthroplasty (THA) in the presence of DDH, long leg radiographs or CT measurements should be used to assess true leg-length discrepancy. Cite this article: Bone Joint J 2019;101-B:297–302.
Predictors of mortality in the elderly patient with a fracture of the odontoid process
Authors: Shafafy R. , Valsamis E. M. , Luck J. , Dimock R. , Rampersad S. , Kieffer W. , Morassi G. L. , Elsayed S. 
Published: February 2019

Aims Fracture of the odontoid process (OP) in the elderly is associated with mortality rates similar to those of hip fracture. The aim of this study was to identify variables that predict mortality in patients with a fracture of the OP, and to assess whether established hip fracture scoring systems such as the Nottingham Hip Fracture Score (NHFS) or Sernbo Score might also be used as predictors of mortality in these patients. Patients and Methods We conducted a retrospective review of patients aged 65 and over with an acute fracture of the OP from two hospitals. Data collected included demographics, medical history, residence, mobility status, admission blood tests, abbreviated mental test score, presence of other injuries, and head injury. All patients were treated in a semi-rigid cervical orthosis. Univariate and multivariate analysis were undertaken to identify predictors of mortality at 30 days and one year. A total of 82 patients were identified. There were 32 men and 50 women with a mean age of 83.7 years (67 to 100). Results Overall mortality was 14.6% at 30 days and 34.1% at one year. Univariate analysis revealed head injury and the NHFS to be significant predictors of mortality at 30 days and one year. Multivariate analysis showed that head injury is an independent predictor of mortality at 30 days and at one year. The NHFS was an independent predictor of mortality at one year. The presence of other spinal injuries was an independent predictor at 30 days. Following survival analysis, an NHFS score greater than 5 stratified patients into a significantly higher risk group at both 30 days and one year. Conclusion The NHFS may be used to identify high-risk patients with a fracture of the OP. Head injury increases the risk of mortality in patients with a fracture of the OP. This may help to guide multidisciplinary management and to inform patients. This paper provides evidence to suggest that frailty rather than age alone may be important as a predictor of mortality in elderly patients with a fracture of the odontoid process. Cite this article: Bone Joint J 2019;101-B:253–259.
Results of Salmonella typhi culture in patients with suspected typhoid fever, treated in the Department of Child Health Medical School, Padjadjaran University, Hasan Sadikin General Hospital Bandung
Authors: Sekarwana Nanan , Garna Herry , S. Azhali M. 
Published: February 2019

From October to December 1984, examination has been carried out on Salmonella typhi cultures from blood, bone marrow, faeces and urine of 43 patients suffering from suspected typhoid fever treated in the Department of Child Health, Medical Schooll Hasan Sadikin General Hospital, Bandung.It was apparent that among these 43 patients, 51.2% were males and 48.8% females. The greater number of them were more than 5 years old (64.4%). The results of Salmonella typhi cultures were obtained from 65% of the patients, consisting of 65% positive cultures from bone-marrow and 40% positive cultures from blood that showed a statistically significant difference (p < 0.05).Likewise, the time for matter-sampling for the examinations was based on the culture results, both on blood-culture and that of bone-marrow, statistically a significant was found (p < 0.05), whereas the results of cultures based on previous vaccination history and the administration of chloramphenicol prior to treatment did not differ significantly.It was obviously clear that the results of bone-marrow culture were more successful compared to those from blood culture, so that it should necessarily be emphasized, as to these examinations on culture from each patient with suspected typhoid fever, especially those patients hospitalized during the third week of their illness.
Toronto’s Smart City: Everyday Life or Google Life?
Authors: Tierney T F 
Published: February 2019

In August 2015, Google reorganized its various interests as a conglomerate called Alphabet Inc. Under the new umbrella, Google’s search, data aggregation, and advertising subsidiaries, were joined by Sidewalk Lab and its suite of urban products: high-speed broadband services, Android Pixel2 phone, mobile mapping, autonomous cars, artificial intelligence, smart homes, and all the data captured therein. The City of Toronto’s recent award to Alphabet’s Sidewalk Lab for design services has sparked a heated controversy among urban planners and citizens alike. Toronto’s decision not only signals a different model of professional practice, but it also represents a conceptual shift away from citizen to urban consumer. By engaging a private technology company, one that passively captures data on its customers and then re-sales that data to third parties, Toronto’s smart city points to a significant change in the understanding and practice of contemporary urban planning and design.
Acknowledging the city as a site of disciplinary disruption, this paper introduces Bratton’s stack theory as a way to understand networked urbanism more generally, and Waterfront Toronto specifically. We build on Bratton’s position by closely examining twenty-first century histories and anthropologies related to the Internet, privacy, and the dominance of big data. Our principal concern is with the transformation of personal and environmental data into an economic resource. Seen through that particular lens, we argue that Toronto’s smart city has internalized relations of colonization, whereby the economic objectives of a multinational technology company take on new configurations at a local level of human (and non-human) information extraction – thereby restructuring not only public land, but also everyday life into a zone of unmitigated consumption.
Peluang dan Tantangan Penerapan Cloud Computing (Komputasi Awan) Sebagai Solusi Automasi Kerjasama Antar Perpustakaan
Authors: Christiani Lydia 
Published: February 2019

Cloud Computing atau komputasi awan bukanlah sesuatu hal yang baru. Meskipun demikian potensi pemanfaatannya belum sepenuhnya disadari oleh masyarakat luas, terlebih potensinya untuk menjadi sarana automasi kerjasama antar perpustakaan. Ketersediaan vendor infrastruktur, software perpustakaan berbasis web, hingga web browser yang telah populer di kalangan masyarakat merupakan modal awal untuk mengimplementasikan komputasi awan pada berbagai layanan perpustakaan. Meskipun di lain sisi perpustakaan harus menghadapi tantangan seperti pendayagunaan SDM dalam perpustakaan sebagai pengelola sistem perpustakaan itu sendiri, serta investasi dalam pembangunan platform komputasi awan. Tantangan-tantangan tersebut dapat diatasi dengan membangun kerjasama, baik secara internal dengan sesama perpustakaan, maupun dengan mendorong dukungan pemerintah serta perusahaan-perusahaan dalam bidang teknologi informasi dan komunikasi.
Pengaruh Pemikiran Raymond C Davis tentang Bibliography Instruction terhadap Konsep Literasi Informasi
Authors: Ganggi Roro Isyawati Permata 
Published: February 2019

Bibliography instruction pertama kali digagas oleh Raymond C. Davis pada tahun 1881. Sejak dilaksanakan pada tahun 1881 bibliography instruction masih tetap dilakukan, meskipun kemudian diperbaharui dengan konsep yang sesuai dengan perkembangan zaman. Raymond C. Davis sendiri merupakan pustakawan di University of Michigan. Davis dianggap sebagai pionir dalam bibliography instruction meskipun ia bukanlah orang pertama yang mencetuskan konsep bibliography instruction. Hal ini dikarenakan Davis adalah orang pertama yang melaksanakan bibliography instruction secara formal dan sistematis. Pada perkembangannya muncul banyak istilah terkait bibliography instruction, seperti library instruction, user education, pendidikan pemakai atau library literacy. Gagasan Davis dalam menjalankan bibliography instruction masih digunakan sampai sekarang, hampir semua perpustakaan memberikan pelatihan kepada penggunanya tentang bagaimana cara memanfaatkan sumber daya yang ada di perpustakaan. Perkembangan teknologi informasi khususnya internet membawa pengaruh juga pada pengajaran bibliography instruction. Paul Zurkowski menjadikan konsep instruksi bibliografi sebagai dasar untuk konsep literasi informasi di tahun 1974. Bibliography instruction oleh Zurkowski dianggap tidak terbatas hanya pengenalan sumber daya di perpustakaan saja, tetapi juga sumber daya informasi di luar perpustakaan. Konsep inilah yang pada akhirnya melahirkan literasi informasi.
PENGGUNAAN PARTIKEL ILOKUSI NE DAN YO DALAM TUTURAN BAHASA JEPANG
Authors: Wiyatasari Reny 
Published: February 2019

(Title: Use of Illocutionary Particle in Japanese Language). The purpose of this study is to explain the use of illocutionary particles ne and yo, the pragmatic meaning generated from a speech and how the influence of the existence of each of these particles in a speech. Because ne and yo are pragmatic rather than semantic and this nature only occurs in verbal interactions, this article takes data from data sources, such as Japanese dramas and Japanese short stories. The data was collected using the observation method through recording and note-taking techniques, and then analyzed using contextual method.From the results of data analysis it was found that ne particles are used when a) request confirmation or ensure information, b) request or seek agreement, c) soften speech, and d) marking the feelings felt by the speaker. While yo particles are used when : a) confirming the question to get a response or reason, b) marking that information (statement) is something new for the listerner, c) emphasizing or affirming a matter/action intended by the speaker in his speech, d) marking speech means encouraging, e) marking utterances that contain expressions of the feeling of the speaker, and f) marking the urge to take action.
MENINGKATKAN KEMAMPUAN KANJI MELALUI MEDIA KANJI GAME ONLINE
Authors: Prasetiani Dyah 
Published: February 2019

(Title: Improving The Capabilities Of Agency Through Media Kanji Game Online) Japanese has several types of letters namely hiragana, katakana, kanji, and romaji. Each letter has its own uniqueness. For foreign learners, kanji is considered the most difficult. The results of interviews on the third semester students who followed the Kanji Shochukyu course showed that students often have difficulty in memorizing kanji, often forget the shape so that they are not able to write kanji correctly, and are often confused between read On and Kun. To overcome student difficulties in memorizing kanji, the author tries to use kanji media online game. The method used is experiment with experiment class and control class. The instrument used is postes. The result of the postes shows that the mean value of the experimental class is 82.5 while the control class is 70.1. Keywords: kanji; game online
Characterizations of ideal cluster points
Authors: Leonetti Paolo , Maccheroni Fabio 
Published: February 2019

Abstract
Given an ideal

{\mathcal{I}}

on ω, we prove that a sequence in a topological space
X is

{\mathcal{I}}

-convergent if and only if there exists a “big”

{\mathcal{I}}

-convergent subsequence. Then we study several
properties and show two characterizations of the set of

{\mathcal{I}}

-cluster points as classical cluster points of a
filter on X and as the smallest closed set
containing “almost all” the sequence. As a consequence, we obtain that the
underlying topology τ coincides with the topology generated by the pair

{(\tau,\mathcal{I})}

.