bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teaching self‐regulation strategies via an intelligent tutoring system (TuinLECweb): Effects for low‐skilled comprehenders
Authors: Serrano M.‐Á. , Vidal‐Abarca E. , Ferrer A. 
Published: April 2018

AbstractThe use of documents to perform tasks is a continuous task demand in the current knowledge‐based society that involves making a series of decisions to self‐regulate the use of text information. Low‐skilled comprehenders have serious problems monitoring and self‐regulating their decisions in these task‐oriented reading situations, which has a negative impact on performance and merits instructional interventions in school settings. Intelligent tutoring systems have emerged as effective tools to teach strategic skills. Herein, we present TuinLECweb, an intelligent tutoring system that teaches monitoring and self‐regulation strategies to young adolescents. Study 1 explores whether high‐skilled and low‐skilled comprehenders respond to the intervention with TuinLECweb differently in terms of task‐oriented reading performance and monitoring accuracy of nonsearch decisions. The results show that the intervention with TuinLECweb primarily benefits low‐skilled comprehenders. Study 2 compares the efficacy of TuinLECweb over a classroom intervention for low‐skilled comprehenders. The results reveal that TuinLECweb training improves monitoring accuracy of nonsearch decisions over and above classroom instruction. Both studies also reveal that low‐skilled comprehenders use the strategies learned beyond the time of training. Our results provide arguments in favour of using computer‐assisted programs in strategy instruction.
Prediction of ventricular tachyarrhythmia in Brugada syndrome by right ventricular outflow tract conduction delay signs
Authors: Ragab Ahmed A.Y. , Houck Charlotte A. , van der Does Lisette J.M.E. , Lanters Eva A.H. , Muskens Agnes J.Q.M. , de Groot Natasja M.S. 
Published: April 2018

AbstractBackgroundBrugada syndrome (BrS) is an autosomal dominant disease responsible for sudden cardiac death in young individuals without structural anomalies. The most critical part in the management of this channelopathy is identification of high‐risk patients, especially asymptomatic subjects. Prior studies have shown that conduction delay in the right ventricular outflow tract (RVOT) is the main mechanism for developing ventricular tachyarrhythmia (VTA) in BrS patients. The aim of this study was to investigate the significance of electrocardiographic RVOT conduction delay parameters as predictors for development of VTA in patients with BrS.Methods and resultsWe retrospectively analyzed electrocardiograms obtained from 147 BrS patients (43 ± 15 years, 65% men) and assessed the following electrocardiographic parameters: (1) Tzou criteria (V1R > 0.15 mV, V6S > 0.15 mV, and V6S:R > 0.2), (2) prominent S wave in lead I, lead II, and lead III, (3) SII > SIII, and (4) prominent Q wave in lead III as possible predictors of VTA occurrences during follow‐up. Prominent SI, SII, SIII, SII > SIII, QIII, and +ve Tzou criteria occurred more frequently in patients who either presented with VTA or developed VTA during the follow‐up of 56 (IQR: 40–76) months. SII > SIII has the highest area under the curve for prediction of VTA (AUC: 0.84, sensitivity: 80%, specificity: 89%). Multivariable regression analysis showed that prominent S waves in lead I, SII > SIII and +ve Tzou criteria are independent predictors for VTA in BrS patients.ConclusionProminent S in lead I, SII > SIII and +ve Tzou criteria can be used as effective signs for predicting VTA in patients with BrS.
Relationship between vitamin D receptor gene polymorphism and susceptibility to chronic kidney disease and periodontal disease in community‐dwelling elderly
Authors: Yoshihara Akihiro , Kaneko Noboru , Iwasaki Masanori , Nohno Kaname , Miyazaki Hideo 
Published: April 2018

AbstractObjectivesThe aim of this study was to investigate the possible correlation between vitamin D receptor (VDR) gene polymorphism and susceptibility to chronic kidney disease (CKD) and periodontal disease.Material and MethodsThis study analysed 345 participants, who were all 79 years of age. Kidney function levels were determined based on the estimated glomerular filtration rate (eGFR; non‐reduced function: ≥60 and reduced function: <60 ml min−1 1.73 m−2). VDR TaqI genotyping was also studied. We calculated the periodontal inflamed surface area (PISA). After classifying participants into quartile groups according to eGFR or PISA values, the subjects were then split into two groups (highest quartile versus the other three groups combined). Multiple logistic regression analysis was performed to evaluate the odds ratios between the eGFR and VDR TaqI genotype with the different PISA groups. The eGFR was set as the dependent variable while the VDR TaqI genotype, HbA1C, gender, smoking habits and body mass index were defined as independent variables.ResultsA significant association was observed between the VDR TaqI genotype and eGFR in the PISA high group (odds ratio = 3.97, p = .027).ConclusionStudy results suggest that VDR TaqI genotype might be associated with CKD during inflammatory conditions caused by periodontal disease.
Drug fever and acute inflammation from hypercytokinemia triggered by dipeptidyl peptidase‐4 inhibitor vildagliptin
Authors: Anno Takatoshi , Kaneto Hideaki , Kawasaki Fumiko , Shigemoto Ryo , Aoyama Yumi , Kaku Kohei , Okimoto Niro 
Published: April 2018

AbstractA 69‐year‐old man started taking the dipeptidyl peptidase‐4 inhibitor, vildagliptin. One week later, C‐reactive protein and plasma immunoglobulin E levels were markedly elevated, and the vildagliptin was stopped. After the patient's laboratory findings were normalized, we decided to restart vildagliptin with the patient's agreement. The next day, he had a high fever, and C‐reactive protein and procalcitonin levels were elevated. Although we failed to find a focus of infection, we started antibiotics therapy. Two days later, the high fever had improved, and the C‐reactive protein level had decreased. A drug lymphocyte stimulation test showed a positive result for vildagliptin. We examined various kinds of cytokine and infection markers just before and after the treatment with vildagliptin. Finally, we diagnosed the patient with vildagliptin‐induced drug fever, probably based on the increase of various inflammatory cytokine levels and the response to this. Taken together, we should be aware of the possibility of vildagliptin inducing drug fever and/or acute inflammation.
Advance Care Planning in Frail Older Adults: A Cluster Randomized Controlled Trial
Authors: Overbeek Anouk , Korfage Ida J. , Jabbarian Lea J. , Billekens Pascalle , Hammes Bernard J. , Polinder Suzanne , Severijnen Johan , Swart Siebe J. , Witkamp Frederika E. , van der Heide Agnes , Rietjens Judith A.C. 
Published: April 2018

ObjectivesTo determine the effectiveness of advance care planning (ACP) in frail older adults.DesignCluster randomized controlled trial.SettingResidential care homes in the Netherlands (N=16).ParticipantsCare home residents and community‐dwelling adults receiving home care (N=201; n=101 intervention; n=100 control). Participants were 75 years and older, frail, and capable of consenting to participation.InterventionAdjusted Respecting Choices ACP program.MeasurementsThe primary outcome was change in patient activation (Patient Activation Measure, PAM‐13) between baseline and 12‐month follow‐up. Secondary outcomes included change in quality of life (SF‐12), advance directive (AD) completion, and surrogate decision‐maker appointment. Use of medical care in the 12 months after inclusion was also assessed. Multilevel analyses were performed, controlling for clustering effects and differences in demographics.ResultsSeventy‐seven intervention participants and 83 controls completed the follow‐up assessment. There were no statistically significant differences between the intervention (–0.26±11.2) and control group (–1.43±10.6) in change scores of the PAM (p=.43) or the SF‐12. Of intervention group participants, 93% completed an AD, and 94% appointed a decision‐maker. Of control participants, 34% completed an AD, and 67% appointed a decision‐maker (p<.001). No differences in the use of medical care were found.ConclusionsACP did not increase levels of patient activation or quality of life but did increase completion of ADs and appointment of surrogate decision‐makers. It did not affect use of medical care.
Motor and Cognitive Trajectories Before Dementia: Results from Gait and Brain Study
Authors: Montero‐Odasso Manuel , Speechley Mark , Muir‐Hunter Susan W. , Sarquis‐Adamson Yanina , Sposato Luciano A. , Hachinski Vladimir , Borrie Michael , Wells Jennie , Black Alanna , Sejdić Ervin , Bherer Louis , Chertkow Howard ,   The Canadian Gait and Cognition Network
Published: April 2018

ObjectivesTo compare the trajectories of motor and cognitive decline in older adults who progress to dementia with the trajectories of those who do not. To evaluate the added value of measuring motor and cognitive decline longitudinally versus cross‐sectionally for predicting dementia.DesignProspective cohort study with 5 years of follow‐up.SettingClinic based at a university hospital in London, Ontario, Canada.ParticipantsCommunity‐dwelling participants aged 65 and older free of dementia at baseline (N=154).MeasurementsWe evaluated trajectories in participants' motor performance using gait velocity and cognitive performance using the MoCA test twice a year for 5 years. We ascertained incident dementia risk using Cox regression models and attributable risk analyses. Analyses were adjusted using a time‐dependent covariate.ResultsOverall, 14.3% progressed to dementia. The risk of dementia was almost 7 times as great for those whose gait velocity declined (hazard ratio (HR)=6.89, 95% confidence interval (CI)=2.18–21.75, p=.001), more than 3 times as great for those with cognitive decline (HR=3.61, 95% CI=1.28–10.13, p=.01), and almost 8 times as great in those with combined gait velocity and cognitive decline (HR=7.83, 95% CI=2.10–29.24, p=.002), with an attributable risk of 105 per 1,000 person years. Slow gait at baseline alone failed to predict dementia (HR=1.16, 95% CI=0.39–3.46, p=.79).ConclusionMotor decline, assessed according to serial measures of gait velocity, had a higher attributable risk for incident dementia than did cognitive decline. A decline over time of both gait velocity and cognition had the highest attributable risk. A single time‐point assessment was not sufficient to detect individuals at high risk of dementia.
Heart Rate and Bone Mineral Density in Older Women with Hypertension: Results from the Korea National Health and Nutritional Examination Survey
Authors: Jung Mi‐Hyang , Youn Ho‐Joong , Ihm Sang‐Hyun , Jung Hae Ok , Hong Kyung‐Soon 
Published: April 2018

OBJECTIVESTo determine whether high heart rate is associated with low bone mineral density (BMD) in older women with hypertension.DESIGNRetrospective cohort study.SETTINGPopulation‐based study conducted in Korea (Korea National Health and Nutritional Examination Survey 2009–10).PARTICIPANTSPostmenopausal women aged 60 and older with hypertension (N=981) divided into 2 groups according to resting heart rate, with a cut‐off value of 80 bpm, which has been found to be associated with osteoporosis.MEASUREMENTSBMD profiles and clinical and laboratory data were collected. Osteoporosis was defined as a T‐score of –2.5 or less, according to World Health Organization criteria.RESULTSBMD was significantly lower in participants with a high heart rate, even after adjustment for age, diabetes mellitus, white blood cell count, and fasting glucose and triglyceride levels. The prevalence of osteoporosis was also significantly higher in those participants. In multivariate logistic regression analysis, the group with high heart rate was 1.7 times as likely (95% confidence interval=1.2–2.3) to have osteoporosis as those with a lower heart rate, independent of age, body mass index, comorbidities, and laboratory findings.CONCLUSIONHigh heart rate is independently associated with lower BMD in older women with hypertension; proactive surveillance of BMD could be helpful when managing older women with hypertension and a high heart rate.
Pattern of antibiotic prescription among dentists in Riyadh, Saudi Arabia
Authors: Baskaradoss Jagan K. , Alrumaih Abdulaziz , Alshebel Abdulrahman , Alfaqih Ahmed , Aleesa Mohammed , Alkhashan Saleh , Altuwaijri Mohamad 
Published: April 2018

AbstractAimThe aim of the present study was to investigate the pattern of antibiotic prescription and dentists' awareness about the recent guidelines for antibiotic prescription.MethodsThis cross‐sectional study was conducted among 282 dentists practicing in Riyadh, Saudi Arabia. The data were collected from 20 randomly‐selected dental clinics from each of the five administrative blocks in Riyadh. In addition, data were also collected from four tertiary care centers and three academic universities. The questionnaire measured the antibiotic prescription pattern of the dentists and their choice of antibiotics for various dental conditions.ResultsAmoxicillin was the most commonly prescribed antibiotic. More than 70% of dentists prescribed antibiotics for dental patients with various cardiac conditions. Bivariate analysis showed that female dentists had significantly higher mean scores for ideal prescription pattern (P = .04) compared to male dentists. Saudi nationals, especially those working in the government sector were found to have better prescription pattern compared with others (P = .02). Dentists with higher educational qualifications (board certificate and above) had a more ideal prescription pattern than other dentists (P = .04).ConclusionInappropriate antibiotic prescription practice was highly prevalent in this population.
Risk factors and topographies for self‐injurious behaviour in a sample of adults with intellectual developmental disorders
Authors: Folch A. , Cortés M. J. , Salvador‐Carulla L. , Vicens P. , Irazábal M. , Muñoz S. , Rovira L. , Orejuela C. , Haro J. M. , Vilella E. , Martínez‐Leal R. 
Published: April 2018

AbstractBackgroundSelf‐injurious behaviour (SIB) is a prevalent form of challenging behaviour in people with intellectual developmental disorders (IDD). Existing research has yielded conflicting findings concerning the major risk factors involved, and in addition, SIB shows multiple topographies and presentations. Although presence of autism spectrum disorders (ASD) and severity of intellectual disability (ID) are known risk factors for SIB, there are no studies comparing SIB topographies by severity degrees of ID and ASD. The purpose of the present paper has been to identify risk factors and topographies for SIB in a representative, stratified and randomised sample of adults with IDD.MethodThis study was conducted on the basis of data collected by the POMONA‐ESP project, in a sample of 833 adults with IDD. Data concerning demographic and health information, ASD symptoms, psychopathology and ID, have been analysed to determine the presence of risk factors for SIB among participants and to explore the occurrence and topographies of SIB across different severity levels of ID and ASD symptoms.ResultsSelf‐injurious behaviour prevalence in the sample was 16.2%. Younger age, oral pain, greater severity of ID, presence of dual diagnosis, psychiatric medication intake and higher scores on Childhood Autism Rating Scale were risk factors for SIB among participants, whereas number of areas with functioning limitations, place of residence, diagnosis of epilepsy and sex were not. SIB was more frequent in participants with ASD symptoms regardless of its severity level, and they displayed a higher number of different topographies of SIB. People with profound ID without co‐morbid ASD symptoms showed similar results concerning SIB prevalence and topographies.ConclusionsKnowledge on risk factors and topographies of SIB might play a vital role in the development of prevention strategies and management of SIB in people with IDD. The mere presence of ASD symptoms, regardless of its severity level, can be a crucial factor to be taken into account in assessing SIB. Accordingly, the presence of SIB in people with ID, especially when presented with a varied number of topographies, might provide guidance on ASD differential diagnosis.
Comparisons of the topographic characteristics and electrical charge distributions among Babesia‐infected erythrocytes and extraerythrocytic merozoites using AFM
Authors: SCUDIERO L. , MERCADO‐ROJANO W. DE J. , RUDOLPH A. , WANG J. , LAUGHERY J.M. , SUAREZ C.E. 
Published: April 2018

SummaryTick‐borne Babesia parasites are responsible for costly diseases worldwide. Improved control and prevention tools are urgently needed, but development of such tools is limited by numerous gaps in knowledge of the parasite–host relationships. We hereby used atomic force microscopy (AFM) and frequency‐modulated Kelvin probe potential microscopy (FM‐KPFM) techniques to compare size, texture, roughness and surface potential of normal and infected Babesia bovis, B. bigemina and B. caballi erythrocytes to better understand the physical properties of these parasites. In addition, AFM and FM‐KPFM allowed a detailed view of extraerythrocytic merozoites revealing shape, topography and surface potential of paired and single parasites. B. bovis‐infected erythrocytes display distinct surface texture and overall roughness compared to noninfected erythrocytes. Interestingly, B. caballi‐infected erythrocytes do not display the surface ridges typical in B. bovis parasites. Observations of extraerythrocytic B. bovis, B. bigemina and B. caballi merozoites using AFM revealed differences in size and shape between these three parasites. Finally, similar to what was previously observed for Plasmodium‐infected erythrocytes, FM‐KPFM images reveal an unequal electric charge distribution, with higher surface potential above the erythrocyte regions that are likely associated with Babesia parasites than over its remainder regions. In addition, the surface potential of paired extraerythrocytic B. bovis Mo7 merozoites revealed an asymmetric potential distribution. These observations may be important to better understand the unique cytoadhesive properties of B. bovis‐infected erythrocytes, and to speculate on the role of differences in the distribution of surface charges in the biology of the parasites.
The Global Landscape of Nursing and Genomics
Authors: Calzone Kathleen A. , Kirk Maggie , Tonkin Emma , Badzek Laurie , Benjamin Caroline , Middleton Anna 
Published: April 2018

AbstractPurposeNurses have a pivotal role in bringing the benefits of genomics and precision medicine to everyday health care, but a concerted global effort is needed to transform nursing policy and practice to address widely acknowledged deficits in nurses’ genomic literacy. The purpose was to conduct a global country and organization review of nursing engagement with genomics, informing a landscape analysis to assess readiness for integration of genomics into nursing.DesignGlobal nursing leaders and nursing organizations were recruited using a purposive sampling strategy to complete an online survey that assessed the scope of genomic integration in practice and education, challenges and barriers, and priorities for action.MethodsThe survey was administered online following an orientation webinar. Given the small numbers of nurse leaders globally, results were analyzed and presented descriptively.FindingsDelegates consisted of 23 nurse leaders from across the world. Genomic services were offered predominantly in specialty centers consisting mostly of newborn screening (15/18) and prenatal screening (11/18). Genomic literacy and infrastructure deficits were identified in both practice and education settings, with only one country reporting a genetic/genomic knowledge and skill requirement to practice as a general nurse.ConclusionsThese data provide insights into the commitment to and capacity for nursing to integrate genomics, revealing common themes and challenges associated with adoption of genomic health services and integration into practice, education, and policy. Such insights offer valuable context and baseline information to guide the activities of a new Global Genomics Nursing Alliance (G2NA). The G2NA will use the landscaping exercise as a springboard to explore how to accelerate the integration of genomics into nursing healthcare.Clinical RelevanceGenomics is relevant to all healthcare providers across the healthcare continuum. It provides an underpinning for understanding health, risks for and manifestations of disease, therapeutic decisions, development of new therapies, and responses to interventions. Harnessing the benefits of genomics to improve health and care outcomes and reduce costs is a global nursing challenge.
Ischemic oculomotor nerve palsy due to hyaluronic acid filler injection
Authors: Bae In Ho , Kim Min Sung , Choi Hoon , Na Chan Ho , Shin Bong Seok 
Published: April 2018

SummaryHyaluronic acid (HA) is the most popular agent today for intradermal injections to improve wrinkles and other cosmetic defects. Ischemic necrosis due to injection of HA is one of the serious complications. Because there are many vascular branches around the nose, caution and care should be given during facial filler injection. Although the incidence is rare, blindness and permanent visual loss may occur. We describe a 29‐year‐old woman presented with painful erythematous swelling with violaceous patch on right periocular area and glabella after HA filler injection. After injecting the filler, she felt pain and dizziness, and her vision became blurred. She immediately received hyaluronidase around the HA filler inject area and during hospitalized for 10 days, she was successfully treated with systemic steroid, vasodilator, prophylactic antibiotics, and LLLT (low‐level laser therapy) without any defects.
Anti‐Hu antibody‐mediated limbic encephalitis associated with cervical cancer: A case report
Authors: Shin Kyong Jin , Ji Yong Il 
Published: April 2018

AbstractA 55‐year‐old postmenopausal and multiparous woman presented to our department with recent memory disturbances associated with rapidly progressive positive Anti‐Hu antibodies. She was subsequently diagnosed with anti‐Hu antibody‐related paraneoplastic limbic encephalitis. Clinical examination and imaging studies revealed a bulky cervical tumor with both parametrial and vaginal fornix extension; biopsy confirmed the tumor as cervical squamous cell carcinoma. In this case, we encountered a patient with anti‐Hu‐mediated paraneoplastic limbic encephalitis with a subsequent diagnosis of cervical cancer.
Ultrasonographic prediction of antepartum deterioration of growth‐restricted fetuses after late preterm
Authors: Yamamoto Ryo , Ishii Keisuke , Nakajima Erika , Sasahara Jun , Mitsuda Nobuaki 
Published: April 2018

AbstractAimTo examine the predictive value of ultrasound parameters for antepartum non‐reassuring fetal status (NRFS) in fetal growth restriction (FGR) cases after late preterm.MethodsRetrospective review of singleton FGR cases before 37 weeks gestation who delivered after 34 weeks gestation was performed. The association between ultrasound parameters that was assessed from 34 to 36 weeks gestation and the development of antepartum NRFS that was diagnosed by nonstress test and biophysical profile was analyzed by using multivariate Cox proportional hazards analyses.ResultsA total of 214 patients were included in final data analyses. Antepartum NRFS occurred in 23 cases (10.7%) including five cases of placental abruption. Lower standard deviation (SD) of estimated fetal weight (EFW), lower cerebroplacental ratio (CPR) and the presence of oligohydramnios were independently associated with antepartum NRFS. The prevalence of antepartum NRFS was highest (50.4%) in the group of EFW ≤−2.5 SD with CPR ≤1.45.ConclusionUltrasound parameters of lower SD of EFW, lower CPR and oligohydramnios were predictive for antepartum NRFS in FGR after late preterm.