bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disruption of Long Noncoding RNAs Targets Cancer Hallmark Pathways in Lung Tumorigenesis
Authors: Davalos Veronica , Esteller Manel 
Published: June 2019

Abstract
Advances in high-throughput genomic and epigenomic technologies have revealed the tremendous complexity of the transcriptional landscape. Beyond protein-coding RNAs (derived from only ∼1.5% of the genome), noncoding RNAs (ncRNA) are emerging as versatile key regulators of gene information involved in multiple major biological processes. Accordingly, deregulation of ncRNA expression has been associated with multiple diseases, including cancer. In this issue of Cancer Research, Shahabi and colleagues characterize LINC00261 as a tumor suppressor long ncRNA epigenetically silenced in lung cancer. They provide crucial mechanistic insights to explain its role in lung tumorigenesis, demonstrating that deregulation of the LINC00261/FOXA2 locus disrupts DNA damage repair signaling, cell-cycle control, and cell proliferation.
See related article by Shahabi et al., p. 3050
Offline Signature Verification and Forgery Detection Based on Computer Vision and Fuzzy Logic
Authors: Prakash Gautam S. , Sharma Shanu 
Published: June 2019

<p>Automated signature verification and forgery detection has many applications in the field of Bank-cheque processing,document authentication, ATM access etc. Handwritten signatures have proved to be important in authenticating a person's identity, who is signing the document. In this paper a Fuzzy Logic and Artificial Neural Network Based Off-line Signature Verification and Forgery Detection System is presented. As there are unique and important variations in the feature elements of each signature, so in order to match a particular signature with the database, the structural parameters of the signatures along with the local variations in the signature characteristics are used. These characteristics have been used to train the artificial neural network. The system uses the features extracted from the signatures such as centroid, height – width ratio, total area, I<sup>st</sup> and II<sup>nd</sup> order derivatives, quadrant areas etc. After the verification of the signature the angle features are used in fuzzy logic based system for forgery detection.</p>
Reducing Hospitalizations: Institution of Outpatient Infusional EPOCH-Based Chemotherapy at a Safety Net Hospital
Authors: Keshvani Neil , Hon Mary , Gupta Arjun , Brown Timothy J. , Roy Lonnie , Marley Eileen , Lindsey Sandy , Johnson David H. , Sadeghi Navid , Li Hsiao C. 
Published: June 2019

PURPOSE: EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin) -based chemotherapy is traditionally administered inpatient because of its complex 96-hour protocol and number of involved medications. These routine admissions are costly, disruptive, and isolating to patients. Here, we describe our experience transitioning from inpatient to outpatient ambulatory EPOCH-based chemotherapy in a safety-net hospital, associated cost savings, and patient perceptions. METHODS AND MATERIALS: Guidelines for chemotherapy administration and educational materials were developed by a multidisciplinary team of physicians, nurses, and pharmacists. Data were collected via chart review and costs via the finance department. Patient satisfaction with chemotherapy at home compared with hospitalization was measured on a Likert-type scale via direct-to-patient survey. RESULTS: From January 30, 2017, through January 30, 2018, 87 cycles of EPOCH-based chemotherapy were administered to 23 patients. Sixty-one ambulatory cycles (70%) were administered to 18 patients. Of 26 cycles administered in the hospital, 18 (69%) were the first cycle of treatment. Rates of inappropriate prophylactic antimicrobial prescription and laboratory testing were lower in the outpatient setting. Eight of nine patients surveyed preferred home chemotherapy to inpatient chemotherapy. Per-cycle drug costs were 57.6% lower in outpatients as a result of differences in the acquisition cost in the outpatient setting. In total, the transition to ambulatory EPOCH-based chemotherapy yielded 1-year savings of $502,030 and an estimated 336 days of avoided hospital confinement. CONCLUSION: Multiday ambulatory EPOCH-based regimens were successfully and safely administered in our safety-net hospital. Outpatient therapy was associated with significant savings through avoided hospitalizations and reductions in drug acquisition cost and improved patient satisfaction.
USP8 Deubiquitinates the Leptin Receptor and Is Necessary for Leptin-Mediated Synapse Formation
Authors: Bland Tyler , Sahin Gulcan Semra , Zhu Mingyan , Dillon Crystal , Impey Soren , Appleyard Suzanne M , Wayman Gary A 
Published: June 2019

Abstract
Leptin has neurotrophic actions in the hippocampus to increase synapse formation and stimulate neuronal plasticity. Leptin also enhances cognition and has antidepressive and anxiolytic-like effects, two hippocampal-dependent behaviors. In contrast, mice lacking leptin or the long form of the leptin receptor (LepRb) have lower cortical volume and decreased memory and exhibit depressive-like behaviors. A number of the signaling pathways regulated by LepRb are known, but how membrane LepRb levels are regulated in the central nervous system is not well understood. Here, we show that the lysosomal inhibitor chloroquine increases LepRb expression in hippocampal cultures, suggesting that LepRb is degraded in the lysosome. Furthermore, we show that leptin increases surface expression of its own receptor by decreasing the level of ubiquitinated LepRbs. This decrease is mediated by the deubiquitinase ubiquitin-specific protease 8 (USP8), which we show is in complex with LepRb. Acute leptin stimulation increases USP8 activity. Moreover, leptin stimulates USP8 gene expression through cAMP response element–binding protein (CREB)–dependent transcription, an effect blocked by expression of a dominant-negative CREB or with short hairpin RNA knockdown of CREB. Increased expression of USP8 causes increased surface localization of LepRb, which in turn enhances leptin-mediated activation of the MAPK kinase/extracellular signal–regulated kinase pathway and CREB activation. Lastly, increased USP8 expression increases glutamatergic synapse formation in hippocampal cultures, an effect dependent on expression of LepRbs. Leptin-stimulated synapse formation also requires USP8. In conclusion, we show that USP8 deubiquitinates LepRb, thus inhibiting lysosomal degradation and enhancing surface localization of LepRb, which are essential for leptin-stimulated synaptogenesis in the hippocampus.
Decreased β-Cell Proliferation and Vascular Density in a Subpopulation of Low-Oxygenated Male Rat Islets
Authors: Ullsten Sara , Lau Joey , Carlsson Per-Ola 
Published: June 2019

AbstractLow-oxygenated and dormant islets with a capacity to become activated when needed may play a crucial role in the complex machinery behind glucose homeostasis. We hypothesized that low-oxygenated islets, when not functionally challenged, do not rapidly cycle between activation and inactivation but are a stable population that remain low-oxygenated. As this was confirmed, we aimed to characterize these islets with regard to cell composition, vascular density, and endocrine cell proliferation. The 2-nitroimidazole low-oxygenation marker pimonidazole was administered as a single or repeated dose to Wistar Furth rats. The stability of oxygen status of islets was evaluated by immunohistochemistry as the number of islets with incorporated pimonidazole adducts after one or repeated pimonidazole injections. Adjacent sections were evaluated for islet cell composition, vascular density, and endocrine cell proliferation. Single and repeated pimonidazole injections over an 8-hour period yielded accumulation of pimonidazole adducts in the same islets. An average of 30% of all islets was in all cases positively stained for pimonidazole adducts. These islets showed a similar endocrine cell composition as other islets but had lower vascular density and β-cell proliferation. In conclusion, low-oxygenated islets were found to be a stable subpopulation of islets for at least 8 hours. Although they have previously been observed to be less functionally active, their islet cell composition was similar to that of other islets. Consistent with their lower oxygenation, they had fewer blood vessels than other islets. Notably, β-cell regeneration preferentially occurred in better-oxygenated islets.
Medicaid DSRIP in New Jersey: Trade-offs between Broad Hospital Participation and Safety Net Viability
Authors: Chakravarty Sujoy , Lloyd Kristen , Farnham Jennifer , Brownlee Susan 
Published: June 2019

Abstract
The Delivery System Reform Incentive Payment (DSRIP) program, an increasingly utilized payment strategy to foster population health management by hospitals and outpatient providers, may sometimes generate financial and operational hardships for safety net hospitals (SNHs). The authors utilized a hospital survey and stakeholder interviews to examine impacts of the New Jersey DSRIP program, particularly focusing on its participatory structure that extended eligibility to all hospitals, and specific effects on SNHs. They found that the New Jersey DSRIP fulfilled its primary objective of conditioning receipt of Medicaid supplementary payments on quality and reporting of care by hospitals. It also provided an impetus to ongoing hospital-directed initiatives and introduced new areas of focus, including behavioral health and obesity. However, stakeholders reported that program implementation was not sensitive to specific constraints, priorities, and resource needs of SNHs. Some of the policies relating to outpatient partnerships, reporting of quality metrics, and monitoring low-income populations were perceived to have placed disproportionate burdens on SNHs. Despite appearing to meet its primary goals, the New Jersey DSRIP experience reveals a critical need to be responsive to problems faced by SNHs so as to limit their short-term transition costs and maintain financial viability for serving their patient populations.
Shuffle Operations on Euler Graphs
Authors: Paramasivan Meenakshi , David N.G. 
Published: June 2019

The shuffle operation on strings is a fundamental operation, well studied in the theory of formal languages. Shuffle on trajectories yields a flexible method to handle the shuffle operation on two strings. In this paper, the shuffle on trajectories is extended to the string representations of Euler graphs and interesting results are obtained. Some algebraic properties such as completeness, determinism and commutativity of the trajectories involved in this study are provided.
On the Minimally Non-outerplanarity of Generalized Middle and Total Graphs
Authors: K Pranavan H P Patil 
Published: June 2019

Systo and Topp introduced the notions of generalized line, middle and total graphs and they studied the planarity and outerplanarity of these classes of graphs. Conditions under which generalized middle graphs and generalized total graphs are minimally non-outerplanar are discussed in this paper.
Keywords : Planar graphs, middle graphs, total graphs, regular graphs, cocktail party graphs, cliques, cutvertices. 1. Introduction
Let
Synthesis and Characterization of Palladium(II) Complexes with Substituted Dihydrobenzoimidazo Quinazoline Derivatives
Authors: Virupaiah Gayathri Rita Bhattacharjee 
Published: June 2019

A series of palladium(II) halo complexes of the types [PdX 2 L 2 ].nH 2 O {n = 0, X = Cl, L = L 2 , L 4 and L 5 ; X = Br, L = L 2 ; n = 1, X = Cl, L = L 1 and L 3 } and Pd 2 X 4 L 3 [X = Br, L = L 1 , L 3 , L 4 and L 5 ] were prepared where L is 6-R-5,6- dihydrobenzoimidazo quinazoline (R-Diq; where R = ethyl: L 1 / n or i-propyl: L 2 , L 3 / n or i-butyl: L 4 , L 5 ) and characterized by elemental analyses, conductivity measurements, TGA, infrared, electronic, NMR and mass spectral techniques. Based on these studies monomeric/dimeric structure with a square planar geometry around the metal ion was proposed for all the complexes. Some of the complexes were investigated for anti-microbial activity.
Potential uses of Parthenium hysterophorous, the obnoxious weed
Authors: S V Chandan 
Published: June 2019

Parthenium hysterophorous is an obnoxious weed and is largely spread all over the world. It widely affects the loss of natural vegetation in the areas of its growth. It has detrimental effects on human health and livestock and also reduces the agricultural produce. Because of its enormous availability, studies have been conducted to validate its employability. Researchers have shown that it can be used efficiently to a considerable level in various fields such as bio manure production & vermi- composting, bioremediation, as a substrate for the synthesis of biomolecules etc. Though the uses of it are explored very little, it has the potential that could be tapped for a few sustainable approaches.
Vertex Triangle Free Detour Number of a Graph
Authors: Sethu Ramalingam S , Keerthi Asir I , Athisayanathan S 
Published: June 2019

The \emph{$x$-triangle free detour number} $dn_{\triangle f_x}(G)$ of a connected graph $G$ is the minimum order of its $x$-triangle free detour sets and any $x$-triangle free detour set $S_{x} \subseteq V$ of order $dn_{\triangle f_x}(G)$ is a \emph{$x$-triangle free detour basis} of $G$. A connected graph of order $n$ with vertex triangle free detour number $n-1$ or $n-2$ for every vertex is characterized. Certain general properties satisfied by the vertex triangle free detour sets are studied.
Patient feedback questionnaires − why bother?
Authors: Kumar Meenakshi , Savage Grazielle C Mattos , Aukett James W , Gallagher Jennifer E 
Published: June 2019

The aim of this article is to encourage general dental practitioners (GDPs) to obtain feedback from patients on a regular basis and act on it. This article will familiarize clinicians with the current concepts of patient experience, patient satisfaction and patient reported outcome measures. It will explore the reasons why dentists should engage in seeking patients' opinions and will shed light on some of the validated questionnaires which are in use in the UK and internationally. Aspects of care considered important by patients are explored and important questions which should be included when developing individual practice questionnaires are highlighted. We build on previous Dental Update articles on this subject by taking the reader through the concept of the Plan Do Study Act (PDSA) cycle and how this can be utilized. This paper will not only allow dentists to improve and grow their practices, but also contribute towards clinical governance and the ethos of patient-centred care. CPD/Clinical Relevance: This article enables dental professionals to appreciate the importance of obtaining patient feedback on key issues relating to their dental care. It suggests ways in which dental teams could engage in obtaining patient feedback and act upon it to develop the quality of services.
A description of a unique paramedic role in a Canadian emergency department
Authors: Clarke Benjamin J , Campbell Samuel G , Froese Patrick , Mann Karen 
Published: June 2019

Background: Paramedics are known for their role in prehospital emergency medical services. In response to healthcare system overcrowding, and increased demands on emergency departments, roles for paramedics have emerged in hospitals. Aims: The authors describe a well established paramedic role in the emergency department of a busy regional referral centre, highlighting the successes and challenges of the programme. Methods: In this phenomenological study, six paramedics employed at the Charles V. Keating Emergency and Trauma Centre were interviewed. Interviews were analysed using thematic content analysis. Findings: Paramedics at the centre are involved in resuscitation, trauma, critical care transport, airway management, and procedural sedation. Performing procedural sedation is an important part of the role and is perhaps where paramedics have had their greatest impact within the department. Conclusions: The diverse scope of practice paramedics maintain at this centre allows them to work where the need is highest within the department, ultimately improving department flow.
Modeling the Relations Among Sustained Attention, Short-Term Memory, and Language in Down Syndrome
Authors: Faught Gayle G. , Conners Frances A. 
Published: June 2019

AbstractSustained attention (SA) and short-term memory (STM) contribute to language function in Down syndrome (DS). We proposed models in which relations of SA to language in DS are mediated by STM. Thirty-seven youth with DS aged 10–22 years (M = 15.59) completed SA, STM, and language tasks. Cross-sectional mediation analyses were run with the bootstrapping method. We found significant indirect effects of SA separately on vocabulary and syntax through auditory STM with point estimates of −.30 and −.31, respectively. Results suggest lapses in SA compromise auditory STM, which in turn impacts vocabulary and syntax in youth with DS; however, further research is needed to confirm causality. Addressing SA and STM in language therapy with youth with DS could lead to improved outcomes.
Computer Assisted Instruction to Teach Academic Content to Students With Intellectual Disability: A Review of the Literature
Authors: Snyder Sara , Huber Heartley 
Published: June 2019

Abstract
Special educators are relying more heavily on computer assisted instruction (CAI) programs to teach academic content to students with intellectual disability (ID) than ever before. Research in this area is growing; however, no formal review of the literature has been conducted to examine the efficacy of using CAI to teach academic content to students with ID. This review explores the nature of academic content taught to students with ID using CAI, the CAI programs used to provide instruction, research methodology, and student learning outcomes associated with CAI. We also address gaps in the research while making suggestions for focusing future efforts to keep pace with changes in technology and the increasing implementation of CAI in special education classrooms.
A Elite do atraso: uma reflexão sobre mecanismos de controle, patrimonialismo, corrupção Estatal e a corrupção invisível do mercado
Authors: Giselle Paiva Rezende  
Published: June 2019

Resenha do livro:
SOUZA, Jessé. A elite do atraso: da escravidão à lava jato. Rio de Janeiro: Leya, 2017.
MRI Experiments as a Tool to Study Asymptotic-Shear Flow Behaviour of a Worm-Like Reverse Micellar Phase
Authors: Coppola Luigi , Gabriele Domenico , Nicotera Isabella , Oliviero Cesare 
Published: June 2019

Abstract
This paper deals with a Magnetic Resonance micro-Imaging (MRI) analysis of asymptotic kinematics which is a condition adopted in some rheological characterisations. Asymptotic kinematics (for example the slow shearing) aim is to evaluate material properties at “equilibrium”, avoiding structural changes induced by external stimuli. Measured material functions in these mechanical conditions deal with the structure/morphology of materials and can be used to investigate the structure as a function of the state variables only, as temperature, pressure and composition. In this paper MRI experiments were performed to study some shear flow behaviours of surfactant wormy micelles made by lecithin/water and diluted in cyclohexane (reverse micellar phase L2). MRI was used as a non-invasive tool in order to follow the structural responses both during slow shearing and when the sample is stirred outside the linear behaviour range. Relations can be found between the typical NMR parameters, strictly related to the microstructure, and the rheological macroscopic parameters as zero-shear viscosity.
A Rheological Study of Binary Mixtures of Ionic Liquid [Me3NC2H4OH]+[Zn2Cl5]− and Ethanol
Authors: Li Qianmei , Wu Guozhong , Liu Yaodong , Luo Yingshe 
Published: June 2019

Abstract
In this paper, by means of Advanced Rheometric Expanded System (ARES), oscillatory and steady shear behavior of binary mixtures of a quaternary ammonium based ionic liquid [Me3NC2H4OH]+[Zn2Cl5]- with ethanol (EtOH) were determined at 25°C and 25-50°C, respectively. The effects of shear rate, temperature and concentration on viscosity were elucidated sufficiently. It was found that the solutions show pseudo-plastic behavior at low shear rate and Newtonian property at higher shear rate. The addition of EtOH caused a substantial decrease in viscosity of the ionic liquid and the viscosity of binary mixtures could be described by an exponential equation. Arrhenius Equation and Power Law equation were applied to describe the respective effects of temperature and shear rate on viscosity. Activation energy derived from Arrhenius equation decreased with increasing the EtOH fraction in the mixture.
In-line Measurement of the Viscous Behaviour of Wheat Starch During Extrusion. Application to Starch Cationisation
Authors: Berzin F. , Tara A. , Tighzert L. 
Published: June 2019

Abstract
A specific twin channel slit die was used to measure in-line the viscous behaviour of an extruded wheat starch. This allows to put in evidence the influences of temperature, water content and specific mechanical energy (SME). The proposed rheological law permits to satisfactorily predict the viscosity of a wheat starch for any processing condition. Original results are presented for the behaviour of cationic starches obtained by reactive extrusion.
Thixotropic Behavior of Fresh Cement Pastes from Inclined Plane Flow Measurements
Authors: Jarny Sébastien , Roussel Nicolas , Le Roy Robert , Coussot Philippe 
Published: June 2019

Abstract
We show that the rheological characteristics of a fresh cement paste can be determined from inclined plane tests. The apparent flow curve measured from inclined plane flows coincides with the apparent rheogram from classical rheometer tests and the flow curve obtained from local Couette flow measurements with magnetic resonance imaging (MRI). In order to describe the thixotropic properties of these fluids we suggest to use a simple model, the four parameters of which may be determined from specific, practical, inclined plane experiments.
The Nonlinear History of Fibre Flow Research. Part 1: Background and Beginning
Authors: Björkman Ulf 
Published: June 2019

Abstract
Technical fibre flows are normally flocky, but have theoretically mainly been treated as individual fibre flows. The reason for this can only be understood in the context of historic development. In Part 1 of this historic investigation the roots of fibre flow research are traced to the beginning of the 19th century. The subsequent development is followed through its formative period in the first half of the 20th century up to about WW2. Part 2 will continue up to about 1960s when the present main tradition had been well established. In Part 2, an example of an alternative approach will also be given, and some proposals for future development presented.
Flow Regimes in Horizontal Viscous Dam-Break Flow of Clayous Mud
Authors: Nsom Blaise , Ravelo Blaise , Ndong Wilfried 
Published: June 2019

Abstract
The main characteristics of geological flows such as debris flows, avalanches and lahars is due to the relative importance of viscous versus inertial forces in the momentum balance. This paper considers the motion generated by the collapse of a dam-retaining mud, itself modeled as a power-law fluid. The equation of motion is derived in a non-dimensional form and solved analytically with the shallow-water assumption in a dry and smooth horizontal channel. Notably indicated are flow regimes and the effect of the reservoir length as well as the effect of mud rheology on flow development. Then, a parametric study of this model is produced and the effect of mud shear-thinning on flow development is pointed out.