bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magmatic evolution and magma chamber conditions of the Alpehué tephra from Sollipulli Volcano, Andean Southern Volcanic Zone, Chile/Argentina
Authors: Freundt Armin , Strehlow Karen , Kutterolf Steffen , Schindlbeck-Belo Julie Christin 
Published: December 2024

Abstract
The trachydacitic Alpehué tephra from Sollipulli volcano (Andean Southern Volcanic Zone), consists of ignimbrite and fallout from a Plinian eruption about 3000 years ago. It is mainly composed of (1) crystal-rich pumice and ash but also contains (2) chilled knobbly basaltic lava clasts and (3) mostly highly inflated glomerocrystic fragments with high crystal-glass ratios interpreted to represent a crystal mush zoned from basaltic to dacitic bulk compositions. Knobbly lava clasts are of three types: (a) a very phenocryst-poor basalt, (b) a basalt with large, unzoned olivine and plagioclase phenocrysts and glomerocrysts, and (c) mixtures of microcrystalline basalt with various fragments, glomerocrysts and crystals derived from a crystal mush. Clast type (4) in the tephra is banded pumices in which the three magmatic components occur variably mingled. Thermobarometry and petrographic observations, particularly presence or absence of amphibole, constrain an upper-crustal succession of a lower basaltic reservoir, a zoned basaltic to dacitic crystal mush reservoir, and a separate trachydacite magma chamber on top. All Alpehué magmatic components form a coherent liquid line of descent which supports the interpretation that the crystal mush reservoir is a gradually solidifying magma chamber, not the result of large-scale crystal-liquid segregation. The trachydacite magma may originally have formed as melt escaping from the crystal-mush reservoir but subsequently underwent a long and complex evolution recorded in large strongly zoned plagioclase phenocrysts including resorption horizons. The ascending mafic magmas collected samples from the crystal mush body and intruded the trachydacite reservoir. The phenocryst-poor basalt (a) arrived first and entrained and partially resorbed plagioclase from the host magma. The phyric basalt (b) arrived later and did not resorb entrained plagioclase before eruption. Estimated cooling times, plagioclase resorption times and ascent rates avoiding amphibole breakdown limit the duration of these pre-eruptive processes to not more than a few days.
Estimation of population affinity using cranial measurements acquired in multidetector computed tomography images of Japanese and Malay individuals
Authors: Torimitsu Suguru , Nakazawa Akari , Flavel Ambika , Iwase Hirotaro , Makino Yohsuke , Hisham Salina , Franklin Daniel 
Published: December 2024

Abstract
It is imperative in a forensic investigation to determine the identity of an unidentified corpse, for which a crucial starting point is to establish population affinity as part of the biological profile supplied by the forensic anthropologist. The present study investigates the feasibility of using multidetector computed tomography (MDCT) images to quantify craniometric variation between Japanese and Malay populations relative to the estimation of population affinity in a forensic context. The Japanese and Malay samples comprise MDCT scans of 252 (122 female; 130 male) and 182 (84 female; 98 male) adult individuals, respectively. A total of 18 measurements were acquired, and two machine learning methods (random forest modeling, RFM; support vector machine, SVM) were applied to classify population affinity. The accuracy of the two-way pooled-sex model was 88.0% for RFM and 94.5% for SVM, respectively. The four-way population and sex model produced an overall classification accuracy of 81.3% for RFM and 91.7% for SVM. The sex-specific models of population affinity showed correct rates of classification of more than 90% in both females (90.8% for RFM and 97.6% for SVM) and males (91.2% for RFM and 97.4% for SVM). Our findings clearly indicate that the cranial measurements acquired in MDCT images can be used for the forensic classification of Japanese and Malay individuals and thus serve as a reference for forensic anthropologists attempting to identify unidentified remains.
Impact of the COVID-19 lockdown period on hospital admissions for paediatric accidents: a French nationwide study
Authors: Recher Morgan , Fall Soxna F. K. , Lockhart-Bouron Marguerite , Lacan Laure , Theis Didier , Leteurtre Stéphane , Bruandet Amélie 
Published: December 2024

Abstract
During the COVID-19 pandemic, lockdown posed a number of unprecedented problems. Accidents to children are a major public health concern. This study sought to determine the impact of France’s 2020 COVID-19 lockdown on hospital admissions for paediatric accidents. This study was a retrospective cohort analysis of data from the French national inpatient database. Children admitted to a French hospital for an accident from January to July 2020 and 2019 were included. The number of admissions for accidents between January and July in 2020 (the study period) vs. the same period (the control period) in 2019 was recorded. Hospital admission rate ratios (HRRs) comparing 2020 with 2019 were calculated for three periods in 2020 and 2019: before lockdown (P1, January 1 to March 15), during lockdown (P2, March 16 to May 10), and after lockdown (P3, May 11 to July 31). A total of 72,089 children were admitted to hospital for accidents between January and July 2020 (mean (SD) age, 8.7 (5.8)), and 84,961 between January and July 2019 (mean (SD) age, 9.2 (5.7)). A total of 12,864 children (18%) were admitted during the lockdown period (P2) in 2020, and 23,098 (27%) during the equivalent period in 2019 (HRR, 0.56; 95% confidence interval (CI), 0.55–0.57; p < .001). There were significantly fewer admissions for accidents in 2020 than in 2019; the HRR was 0.97 (95% CI, 0.96–0.99; p = .003) for P1 and 0.95 (95% CI, 0.93–0.96; p < .001) for P3. During the 2020 lockdown period (P2), the risk of accident-related paediatric admissions with critical care lasting for at least 1 day was lower than in 2019 (HRR 0.67; 95% CI, 0.62–0.73; p < .001).

Conclusions: Further research could usefully examine how parents create a safe home environment for their children.

What is Known:• During the COVID-19 pandemic, lockdown posed a number of unprecedented problems. Accidents to children are a major public health concern. This study sought to determine the impact of France’s 2020 COVID-19 lockdown on hospital admissions for paediatric accidents.

What is New:• The first nationwide COVID-19 lockdown in France was associated with a decrease in the absolute number of hospital admissions for paediatric accidents, for all age groups, as well as the number of accident-related paediatric hospital stays involving critical care.
Response to induction chemotherapy as a prognostic indicator in locally advanced head and neck squamous cell carcinoma
Authors: Huwyler Francesca , Giger Roland , Bill Ruben , Rauch Daniel , Haefliger Simon 
Published: December 2024

Abstract

Purpose
Induction chemotherapy (IC) for patients with locally advanced stage Head and Neck Squamous Cell Carcinomas (HNSCC) before radio-chemotherapy (RCT) or surgery remains a potential treatment option. This study analyzed how the response to IC correlates with survival outcomes.

Methods
We conducted a retrospective single-center study at a tertiary cancer center. Tumors were categorized by anatomical site and response to IC (non-responders vs. responders). Data were analyzed using Kaplan-Meier survival curves and Cox regression analysis.

Results
A total of 48 patients received IC. Of these, 33 patients were radiologically evaluable for response. The majority of evaluable patients received either TPF (Docetaxel, Cisplatin, 5-Fluorouracil) (58%) or TP (Docetaxel, Cisplatin) (24%) as their IC regimen. Tumor reduction of 30% or more was observed in 23 patients (69.7%), the tumor control rate was 97%. The 2-year event-free survival (EFS) in the IC evaluable population was 53.1%, overall survival (OS) was 63.6%, and recurrence-free survival (RFS) was 62.5%. Patients with laryngeal or hypopharyngeal tumors that did not respond to IC had a significantly poorer prognosis. This effect was not statistically significant in tumors of the oral cavity or oropharynx, where it was only observed as a trend.

Conclusion
IC is highly effective in treating locally advanced stage HNSCC. The response to IC is prognostic for survival, particularly in cancers of the larynx and hypopharynx.
Quantification of hemi-hepatic ischemia using real-time multispectral oxygenation imaging with single snapshot imaging of optical properties (SSOP)
Authors: Mishima Kohei , Goglia Marta , Baratelli Luca , Pardo Arturo , Carlino Giorgio , Oliva Riccardo , Famularo Simone , Hernandez-Lara Ariosto , Reitano Elisa , Riva Pietro , Lapergola Alfonso , Marescaux Jacques , De Mathelin Michel , Felli Eric , Gioux Sylvain , Diana Michele 
Published: December 2024

Abstract

Background
Identifying liver ischemia is crucial in liver surgery. This study aimed to develop a hemi-hepatic ischemia model for assessing liver ischemia using single snapshot imaging of optical properties (SSOP), a noninvasive optical imaging modality that provides real-time measurements of tissue oxygen saturation (StO2).

Materials and methods
Twelve swine were randomly assigned to two groups: One undergoing total vascular inflow occlusion (TVIO) and the other undergoing hepatic artery occlusion (HAO). Preoperative 3D CT scans were used to locate the left-sided hepatic arteries and portal veins, which were clamped during surgery. Real-time SSOP imaging was conducted to measure StO2 in three lobes—the left lateral lobe (LL), left medial lobe (LM), and right medial lobe (RM)—as well as capillary lactate levels and Doppler blood flow. Measurements were recorded at baseline (T0), during ischemia (T1, 30 min after clamping), and during reperfusion (T2, 30 min after declamping).

Results
In the TVIO group, SSOP imaging revealed a distinct demarcation line on the liver surface. StO2 levels measured by SSOP significantly decreased from T0 to T1, dropping by 29.8% in the LL (46.0 ± 5.1 vs. 16.2 ± 5.1%, p = 0.011) and 36.3% in the LM (42.7 ± 5.9 vs. 6.4 ± 4.0%, p = 0.001). Additionally, capillary lactate levels increased substantially in the LL (1.3 ± 0.4 vs. 8.5 ± 2.4 mmol/L, p = 0.041) and in the LM (1.3 ± 0.4 vs. 8.2 ± 2.1 mmol/L, p = 0.021). In contrast, the HAO group showed a less pronounced reduction in StO2: 13.6% in the LL (32.7 ± 6.4 vs. 19.1 ± 5.4%, p = 0.007) and 19.8% in the LM (35.3 ± 8.2 vs. 15.5 ± 5.8%, p = 0.011), with no significant increase in capillary lactate levels. An inverse correlation was found between StO2 and capillary lactate levels (r = − 0.76, p < 0.001).

Conclusion
SSOP is a real-time, contrast-free imaging technique that effectively evaluates liver ischemia by accurately measuring tissue oxygenation, as validated by perfusion biomarkers.
Challenges and Safety Considerations in the Transportation of Dangerous Goods through Tunnels
Authors: Patsekha Aliaksei 
Published: December 2024

AbstractThis article explores the transportation of dangerous goods (DG) through tunnels, emphasising the associated challenges and safety considerations within this crucial infrastructure. It provides a detailed analysis of statistical data on DG transportation, specifically focusing on industrial hazardous substances in liquid or gaseous forms that can cause severe damage in underground environments, even in the absence of fire or explosion. By reviewing past incidents involving dangerous agents and critically evaluating current research, the article identifies significant gaps in safety protocols and emergency response strategies. It highlights the urgent need for comprehensive research to enhance safety standards and improve resilience in tunnel environments.
Consensus statement on chronic pain treatment in cancer survivors
Authors: Mamiya Keiko , Iida Hiroki , Iseki Masako , Yamaguch Shigeki , Yonekura Hiroshi , Ueno Hiroshi , Kosugi Toshifumi , Sasara Takeshi , Takao Yumiko , Takasusuki Toshifumi , Hashiguchi Saori , Hirakawa Naomi , Sugiyama Yoko , Yamada Keiko , Yamamoto Kenji 
Published: December 2024

Abstract
In September 2023, the Japan Society of Pain Clinicians (JSPC) issued this consensus statement on chronic pain treatment in cancer survivors. With recent advances in the early diagnosis and treatment of cancer, its prognosis has improved, so prolonged pain in cancer survivors is considered to represent chronic pain and should be addressed. In this statement, we emphasize that not all cancer survivor pain is cancer pain. Pain that is not cancer pain should be managed with analgesics other than opioids and nerve blocks, and pain that persists despite this approach should be treated as non-cancer chronic pain so as to prevent opioid overuse. In addition, cancer survivors at any stage of disease have a potentially life-threatening condition and constantly carry the fear of cancer recurrence. Therefore, even non-cancer pain should not be treated in the same way as general chronic pain, but should be managed with consideration of emotional distress. In the future, we plan to create educational tools for healthcare professionals and to conduct online seminars, both with the goal of providing cancer survivors with appropriate assessment and treatment of chronic pain.
Intercalation of the anticancer drug lenalidomide into montmorillonite for bioavailability improvement: a computational study
Authors: Meruvia-Rojas Yumeida V. , Molina-Montes Esther , Hernández-Laguna Alfonso , Sainz-Díaz C. Ignacio 
Published: December 2024

Abstract

Context
Lenalidomide (LEN) is used for the treatment of myeloma blood cancer disease. It has become one of the most efficient drugs to halt this disease. LEN is a low-soluble drug in aqueous media. The search of a pharmaceutical preparation to improve the bioavailability and, therefore, to optimize its efficiency is an important issue for pharmaceutical industries and health care. The use of natural excipients such as montmorillonite (MNT) can provide changes in the physical–chemical properties for improving the bioavailability of this drug. We present the first computational study at the atomic scale of the periodic crystal forms of the polymorphs for this anticancer drug, highly demanded in the pharmacy market. In addition, we propose a pharmaceutical preparation by intercalation of LEN in natural MNT. So, our calculations predict that LEN can be intercalated in the interlayer space of MNT, and be released in aqueous media, and physiological aqueous media in consequence. This release process is a more exothermic reaction than the unpacking energy of any of its polymorphs. Besides, the infrared spectra of the LEN molecule and its crystal polymorphs, and LEN intercalated in the confined space of MNT, have been calculated at different levels of theory. The band frequencies have been assigned, matching with the experimental bands, predicting the use of this technique for experimental studies.

Method
In this work, the method is aimed to explore this research at the atomic and molecular level by using computational modelling methods including INTERFACE FF and other FF along with quantum mechanical calculations (Dmol3 and CASTEP) of 3-D periodical systems applying periodical boundary conditions. Models of the isolated molecule and two polymorphs of the crystal structures, with the model of bulk water and LEN intercalated in the MNT model, have been considered. An analysis of the intermolecular interactions is accomplished.
Methane upgrading on pelletised Maxsorb activated carbon by gas-phase simulated moving bed
Authors: Dias Rafael O. M. , Regufe Maria J. , Pereira Ana A. , Ferreira Alexandre F. P. , Rodrigues Alírio E. , Ribeiro Ana M. 
Published: December 2024

Abstract
To study the separation of methane and nitrogen mixtures by gas-phase simulated moving bed (SMB), Maxsorb activated carbon was pelletised by extrusion with 10% binder. Both argon and carbon dioxide were used as potential desorbent gases. The effectiveness of the adsorbent was assessed by analysing the adsorption equilibrium data and conducting fixed-bed experiments to determine the single and multicomponent dynamic adsorption behaviour. Pure component N2, CH4, Ar, and CO2 isotherms were measured at three different temperatures, up to 2.5 bar, using a volumetric method. The results show that CO2 exhibits the highest affinity to the solid phase, followed by CH4, N2, and Ar. Single, binary, and ternary fixed-bed experiments were performed, allowing the validation of the proposed mathematical model. Two SMB cycles were designed to separate a CH4/N2 mixture using each desorbent gas. The respective separation regions were drawn. Both processes achieved a high purity level for the methane stream (above 99%) and exhibited high recovery (above 97%). The obtained results were crossed with the previously studied BPL material, and the Maxsorb adsorbent showed better performance overall.
The role of body composition in neurological and hematologic toxicity in a retrospective analysis of 120 breast cancer patients undergoing neoadjuvant chemotherapy: the COMBOTOX study
Authors: Di Leone A. , Filippone A. , Maggiore C. , Rossi M. M. , Rossi C. , Di Micco A. , Forcina Luana , Franco A. , Ionta L. , Fabi A. , Paris I. , Scardina L. , Sanchez A. M. , Pafundi P. C. , Franceschini G. , Masetti R. , Magno S. 
Published: December 2024

Abstract

Purpose
Neoadjuvant chemotherapy (NAC) has a well-established role in locally advanced or chemoresponsive breast cancers (BC). Chemotherapic regimens are effective when patients receive the optimal doses. Toxicities are common in overweight/obese patients but may occur also in normal weight counterparts. This leads to delays, reductions, or discontinuation of treatment, with impact on outcomes. Current dosing is based on body weight and predicted Body Surface Area (BSA). These parameters do not take into consideration the individual variations of fat mass (FM) and fat-free mass (FFM) that affect pharmacokinetics. Assessment of body composition (BoCo), rather than Body Mass Index (BMI), could help to better plan chemotherapy and reduce drug-related toxicities. Our aim was to analyze the correlations between body weight, anthropometric measures, BoCO, and toxicities related to NAC in non-metastatic BC patients.

Methods
This is a retrospective observational cohort study that includes 120 consecutive BC patients undergoing NAC, enrolled between May 2018 and December 2020. All patients received an evaluation of anthropometric parameters (height, weight, waist and hip circumference, BMI) and an assessment of BoCo using Segmental Multi-Frequency-Bioelectrical Impedance Analysis.

Results
A logistic regression models confirmed that a higher FM was associated with a higher rate of neurological and hematologic toxicities in protocols containing Platinum. Moreover, patients with a low FFM% have a higher risk for hematologic toxicity in protocols containing Platinum.

Conclusion
A routine assessment of BoCo, in addition to evaluation of anthropometric measures and BMI, could allow to personalize chemotherapy doses, in order to reduce chemotherapy-related toxicities.
Virtue Ethics in Marketing: The Art of Crafting Tragic Brand Stories
Authors: Brokalaki Zafeirenia 
Published: December 2024

AbstractThe paper explores the role of marketing stories in cultivating virtue ethics in consumers. Drawing from the philosophy and storytelling tradition of the Aristotelian tragedy along with Kierkegaard’s Either/Or and Castoriadis’ insights, it is illustrated that tragic stories can be a valuable creative resource for marketing professionals who wish to promote virtue ethics in the marketplace. To achieve this, the paper: a) illuminates the value of virtue-oriented stories in marketing; b) critically examines the value of existing brand stories; c) proposes an alternative brand storytelling orientation, based on the tradition of tragedy, which fosters virtue ethics; d) offers a framework and guidelines to brand executives who want to craft tragic brand stories.
Place-based climate commissions: embracing messy governmentality
Authors: Howarth C. , Edwards L. , Duncan A. , Van der Horst D. , Pringle R. 
Published: December 2024

AbstractThe role of the ‘place’ in delivering climate action is vital, however much action on climate change locally is fragmented. Independent place-based climate commissions are a novel structure of climate governance developing at the subnational level across cities, regions and counties in the UK. Little is known about these emerging forms of local climate governance and their experiences of navigating ‘mess’ in governance practices and processes. Building on Castán Broto’s framework of messy governmentalities, this paper seeks to assess the capacity of climate commissions to affect meaningful climate mitigation and adaptation action, to understand how they interact with existing climate governance structures and to consider their longer-term sustainability. This paper examines the nature and impact climate commissions have had on local climate action, drawing on qualitative interviews with chairs, commissioners, members of the secretariat and associated local authorities of the Edinburgh, Belfast, Leeds, Surrey, Yorkshire and Humber, and Lincoln commissions in the UK. Analysing the journeys of the commissions through a lens of messy governmentalities, and a focus on bodies, strategies and knowledges within them, we draw out insights on how climate commissions came about, their function and role, their impact and influence, and how they have evolved.
Evaluation of carp sperm respiration: fluorometry with optochemical oxygen sensor versus polarography
Authors: Musatova Iryna , Dzyuba Borys , Boryshpolets Serhii , Iqbal Azeem , Sotnikov Anatolii , Kholodnyy Vitaliy , Dzyuba Viktoriya 
Published: December 2024

Abstract
The primary function of spermatozoa is to fertilize the oocyte, which depends on their motility and is directly associated with their metabolic state. The oxygen consumption rate (OCR) of spermatozoa reflects the respiratory capacity of sperm mitochondria under various physiological conditions and is an essential marker of sperm quality. We determined the OCR of common carp (Cyprinus carpio) sperm using two respirometry methods: the conventionally used polarographic method with a Clark-type electrode and fluorometric assay with an Oxo Dish optochemical oxygen sensor. The latter was used for the first time to evaluate spermatozoa oxygen consumption in various metabolic states (under different treatments) at different dilution rates. These two methods were compared using Bland–Altman analysis, and the applicability of the optochemical oxygen sensor for evaluating carp sperm oxygen consumption was discussed. Sperm motility and progressive velocity parameters were also assessed to evaluate the effect of sperm respiration under different metabolic states and dilution rates and preincubation period on the physiological status of spermatozoa. The comparison of these respirometry methods clearly shows that while the polarographic method allows immediate measurement of oxygen levels after adding a sperm sample, the optochemical oxygen sensor has a priority in the amount of data obtained due to simultaneous measurements of several samples (e.g., different males, different fish species, repetitions of the same sample or various experimental conditions), even at a later time after adding sperm to the measuring chamber. However, the compared methods are complementary, and the proposed methodology can be applied to other fish species.