bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Correlation of Shoe Size and Component Size of Primary Total Knee Arthroplasty
Authors: van Egmond Jeroen Cornelis , Verburg Hennie , Hesseling Brechtje , Mathijssen Nina Maria Cornelia 
Published: February 2019

AbstractPreoperative planning is an important phase of total joint arthroplasty. Current template programs and methods only provide moderate accuracy for implant size prediction. Recently, a relationship between shoe size and implant size was found. We hypothesized that shoe size shows a high percentage of agreement for implant size of both femoral and tibial component size in primary total knee arthroplasty (TKA). The aim of this study was to investigate the correlation and agreement between shoe size and TKA implant size. We performed a retrospective cohort study. Of all patients, who underwent primary TKA between September 2013 and March 2016, shoe size and knee implant sizes were collected. Cross-tabulation was used to determine the correlation and agreement between shoe size and implant size. A total of 489 patients (498 TKA) were included. The correlation coefficient for femoral and tibial component with shoe size was 0.751 and 0.759, respectively. When a deviation of ± 1 component size was allowed, shoe size gave at least 94% agreement score for femoral component and at least 86% agreement score in tibial component. We conclude that both femoral and tibial component size have a good correlation with shoe size. Therefore, shoe size may be used as a valuable predictor in preoperative implant size planning for primary TKA. The level of evidence for this study was Level IV.
Less Invasive Surfactant Administration in Spain: A Survey Regarding Its Practice, the Target Population, and Premedication Use
Authors: Fernandez Cristina , Boix Hector , Camba Fatima , Comuñas Juan Jose , Castillo Felix 
Published: February 2019

Objective Scientific evidence supports the use of less invasive surfactant administration (LISA) techniques, but certain issues may be limiting its generalized incorporation in clinical practice. The objectives were to determine the level of acceptance of LISA techniques in Spanish hospitals, the types of methods used, the target population, and the premedication administered.
Study Design An online survey was designed and sent to various secondary/tertiary hospitals in Spain.
Results Among 67 neonatal units contacted, 44 (65.7%) participated. LISA was used in 89%, and those that did not perform the technique were contemplating its use in the future. In total, 77% of hospitals used some type of pharmacologic sedation/analgesia before the procedure: 28% always and 49% sometimes. In all cases, the reason for premedication was concerned about pain and discomfort. The types of drugs and doses varied.
Conclusion LISA has been incorporated in clinical practice of the hospitals surveyed, with a utilization rate higher than what has been reported to date. Sedation and analgesia are commonly administered. LISA is viewed as potentially involving some degree of pain and discomfort. Further studies are needed to determine the safest and most effective pharmacologic and nonpharmacologic measures to apply in these procedures.
Bone Sandwich Closure Technique for Posterior Fossa Craniectomy
Authors: Krishnan Shyam Sundar , Nigam Pulak , Manuel Adarsh , Vasudevan Madabushi Chakravarthy 
Published: February 2019

Background Surgery of posterior fossa including cerebellopontine (CP) angle involves either craniectomy or craniotomy. While there has been precedence of craniotomy in recent practice, the preferred access in resource-strapped centers still remains been craniectomy. Although the latter offers an excellent exposure, it is believed to carry increased risk of postoperative pseudomeningocoele and cerebrospinal fluid (CSF) leak compared with craniotomy.
Methods We have suggested a technique by which after standard craniectomy for the posterior fossa surgeries the bony defect is covered by Gelfoam bone sandwich (GBS) technique. We studied this technique over a period of 25.6 years in 1,028 patients.
Results and Conclusion We analyze the risk of pseudomeningocoele and CSF leak in our patients using GBS technique and reviewed literature to compare our outcomes with standard craniotomy and craniectomy procedures.
Epistemic stancetaking and speaker objectification in a spatio-cognitive discourse world
Authors: Ullmann Stefanie 
Published: February 2019

AbstractThis paper seeks to apply a cognitive-linguistic approach to critical discourse studies in an investigation of epistemic stancetaking and types of inter/subjectivity of the speaker in political discourse. More specifically, the paper presents an analysis of responses by three different politicians, i.e. John Kerry, Bashar al-Assad and Vladimir Putin, to the chemical weapons attack in Syria in August 2013. By incorporating cognitive-linguistic theories in a critical investigation of language, I address diverging representations of the same event and their discursive functions in representing underlying ideologies and motifs of the respective politicians. Specifically, I propose a more nuanced incorporation of epistemic stance in a spatio-cognitive representation of discourse. My analysis shows that type of inter/subjectivity has bearing on the epistemic quality of a proposition. The more prominently a speaker construes him-/herself as evaluator of an event, the stronger his/her assertions become, which is equally visible in a discourse space model.
Engineering registers in the 21st century
Authors: Gardner Sheena , Xu Xiaoyu 
Published: February 2019

Abstract
Following an exploration of engineering programmes in higher education, and a review of literature on engineering registers, genres
and disciplines, this paper asks if there is a register for engineering. Word frequencies, n-grams and frequent n-grams in context
were analysed in a 7.3 million word corpus created from four sections (Introduction, Materials & Methods, Results &
Discussion, Conclusion) of over 1000 articles in civil, electrical and mechanical engineering. From the perspective of systemic
functional linguistics, this reveals how engineering is construed through language that reflects the social context of high
impact, open access, multi-modal, 21st century, international journal article publication, with multiple author roles, and
prescribed genres, where reviewers focus on problem solving and facts, rather than persuasive claims.
The discipline of English Literature from the perspective of SFL register
Authors: Huisman Rosemary 
Published: February 2019

AbstractThe paper first traces the history and elaboration of the tertiary discipline English Literature through the 19th and 20th centuries to the present day, with special focus on the axiology, the values, given to the discipline and with a brief account of literary criticism and literary theory. It then refers to the work on registerial cartography in systemic functional linguistics (SFL) and explores the register of the contemporary discipline in first-order field of activity and second-order field of experience, with examples from the language of webpages and exam papers of Australian universities. It continues with a brief overview of the author’s own work using SFL in the study ofthe poeticandthe narrativein English poetry and prose fiction of different historical periods and concludes with a caveat on the central disciplinary process, that of interpretation.
The language of educational linguistics in Hispanic Latin America
Authors: Navarro Federico 
Published: February 2019

AbstractThis study aims to identify patterns of the system ofthemein Spanish in 28 educational linguistics’ articles, an emerging field in Latin America. Results show a high number of textual and elaborated interpersonal Themes (especially in Conclusions), alongside a frequent choice of marked Themes (especially in Introductions) which adjust thematic strings, while the Subject is usually explicit and previous to the verb. Educationally-oriented articles tend to use more interpersonal Themes and preposed explicit Subjects, in what seems to be a disciplinary validation struggle. This research can help understand the construction of a new disciplinary discourse, connecting semantic and lexicogrammatical patterns to epistemological frameworks, while providing evidence to the realization of Theme and Subject across stages, disciplines and languages.
From perfect to narrative tense
Authors: Greed Teija 
Published: February 2019

Abstract2,500 years ago Pāṇini identified the Sanskrit perfect form as expressing a non-witnessed, and therefore, evidential meaning. Across languages, the perfect is still attested as one of the central verb forms acquiring meanings of information source. This paper investigates the development of the perfect meaning into evidential meanings from two vantage points: firstly, cross-linguistically, and, secondly, in the North-Tungusic language Even. The perfect meaning typically evolves into the evidential meaning of inference, a development which has been documented in two of the three main dialects of Even byMalchukov (2000). Inference is accompanied by a mirative interpretation in first-person contexts; the current study shows that this interpretation extends to second person. As is cross-linguistically common, in Even inference has evolved to a non-witnessed meaning. By losing its perfect “nature”, this use has crossed over to the domain of discourse to signal a narrative genre by functioning as a narrative tense.
A second countable locally compact transitive groupoid without open range map
Authors: Buneci Mădălina 
Published: February 2019

Dana P. Williams raised in [Proc. Amer. Math. Soc., Ser. B 3 (2016), pp. 1–8] the following question: Must a second countable, locally compact, transitive groupoid have open range map? This paper gives a negative answer to that question. Although a second countable, locally compact transitive groupoid

G
G

may fail to have open range map, we prove that we can replace its topology with a topology which is also second countable, locally compact, and with respect to which

G
G

is a topological groupoid whose range map is open. Moreover, the two topologies generate the same Borel structure and coincide on the fibres of

G
G

.
Nonsteroidal anti-inflammatory drugs and necrotizing fasciitis
Authors: Browne Barry A. , Holder E. Paul , Rupnick Leanne 
Published: February 2019

Abstract
The clinical features, etiology, and treatment of necrotizing fasciitis are reviewed, and the possible involvement of nonsteroidal anti-inflammatory drugs (NSAIDs) in the pathogenesis of this disease is discussed.
Symptoms of necrotizing fasciitis include edema, erythema, warmth, and tenderness in the affected area, spreading rapidly to involve entire limbs or portions of the abdominal wall. Gangrene may develop, followed by multi-organ failure and death. The most common causative organisms are group A beta-hemolytic streptococci. Treatment includes tissue debridement, intravenous antibiotics, and supportive treatment with fluids and electrolytes. A number of case reports and articles in the lay press have suggested an association between the use of NSAIDs and the development of necrotizing fasciitis, although this association has not been substantiated in the scientific literature. Inhibition of the immune response has been proposed as an explanation for the reported association between necrotizing fasciitis and NSAIDs.
NSAIDs should be administered with caution, if at all, to patients with inflammatory soft-tissue lesions, especially if concurrent infection is likely.
Relationship between hospital pharmacists’ job satisfaction and involvement in clinical activities
Authors: Olson David S. , Lawson Kenneth A. 
Published: February 2019

Abstract
Job satisfaction among hospital pharmacists employed by a national hospital pharmacy management company was measured by using a mail questionnaire.
A previously validated survey that measured pharmacists’ job satisfaction was adapted for use in this study. Additional questions determined the pharmacist’s clinical pharmacy training and participation in clinical pharmacy services. Questionnaires were mailed to all full-time hospital pharmacists employed by the pharmacy management company.
Of the 606 mailed, deliverable questionnaires, 354 usable responses were returned, for a response rate of 58.4%. The respondent hospital pharmacists’ level of job satisfaction showed a positive association with clinical pharmacy involvement. Of the nine items in the questionnaire that measured the pharmacists’ involvement in clinical pharmacy services, seven items showed a positive relationship between involvement in that clinical activity and job satisfaction. Mean job satisfaction increased as the percentage of time spent performing clinical pharmacy activities increased. Job satisfaction decreased as time spent performing distributive functions increased.
The percentage of time hospital pharmacists were engaged in clinical activities was significantly associated with job satisfaction.
Clinical application of embryo aneuploidy testing by next-generation sequencing
Authors: Rubio Carmen , Rodrigo Lorena , Garcia-Pascual Carmen , Peinado Vanessa , Campos-Galindo Inmaculada , Garcia-Herrero Sandra , Simón Carlos 
Published: February 2019

Abstract
We review here the evolution in the field of embryo aneuploidy testing over the last 20 years, from the analysis of a subset of chromosomes by fluorescence in situ hybridisation to the transition toward a more comprehensive analysis of all 24 chromosomes. This current comprehensive aneuploidy testing most commonly employs next-generation sequencing (NGS). We present our experience in over 130 000 embryo biopsies using this technology. The incidence of aneuploidy was lower in trophectoderm biopsies compared to cleavage-stage biopsies. We also confirmed by NGS that embryo aneuploidy rates increased with increasing maternal age, mostly attributable to an increase in complex aneuploid embryos. In contrast, the number of MII oocytes retrieved or the use of oocyte vitrification did not affect aneuploidy rates. Similarly, neither maternal age, oocyte number, nor oocyte vitrification affected the incidence of mosaicism. Analysis of clinical outcomes, indications, and potential benefits of embryo aneuploidy testing revealed advanced maternal age as the most favored group, with some evidence of improved delivery rate per transfer as well as decreased miscarriage rates and time to pregnancy. Other indications are: recurrent miscarriage, repetitive implantation failure, severe male factor, previous trisomic pregnancy, and good prognosis patients mainly undergoing single embryo transfer, with the latter indication used to reduce the occurrence of multiple pregnancies without compromising cycle outcome. In conclusion, NGS has become the most appropriate technology for aneuploidy testing in trophectoderm biopsies, with accurate results, high throughput, and cost efficiency. This technology can be also applied to the analysis of the embryonic cell free DNA released to the culture media at blastocyst stage. This is a promising approach towards a non-invasive preimplantation genetic testing of aneuploidy.
Acute Q Fever Endocarditis: A Paradigm Shift Following the Systematic Use of Transthoracic Echocardiography During Acute Q Fever
Authors: Melenotte Cléa , Epelboin Loïc , Million Matthieu , Hubert Sandrine , Monsec Thierry , Djossou Félix , Mège Jean-Louis , Habib Gilbert , Raoult Didier 
Published: February 2019

AbstractBackgroundAs Q fever, caused by Coxiella burnetii, is a major health challenge due to its cardiovascular complications, we aimed to detect acute Q fever valvular injury to improve therapeutic management.MethodsIn the French national reference center for Q fever, we prospectively collected data from patients with acute Q fever and valvular injury. We identified a new clinical entity, acute Q fever endocarditis, defined as valvular lesion potentially caused by C. burnetii: vegetation, valvular nodular thickening, rupture of chorda tendinae, and valve or chorda tendinae thickness. To determine whether or not the disease was superimposed on an underlying valvulopathy, patients’ physicians were contacted. Aortic bicuspidy, valvular stenosis, and insufficiency were considered as underlying valvulopathies.ResultsOf the 2434 patients treated in our center, 1797 had acute Q fever and 48 had acute Q fever endocarditis. In 35 cases (72%), transthoracic echocardiography (TTE) identified a valvular lesion of acute Q fever endocarditis without underlying valvulopathy. Positive anticardiolipin antibodies (>22 immunoglobulin G-type phospholipid units [GPLU]) were independently associated with acute Q fever endocarditis (odds ratio [OR], 2.7 [95% confidence interval {CI}, 1.3–5.5]; P = .004). Acute Q fever endocarditis (OR, 5.2 [95% CI, 2.6–10.5]; P < .001) and age (OR, 1.7 [95% CI, 1.1–1.9]; P = .02) were independent predictors of progression toward persistent C. burnetii endocarditis.ConclusionsSystematic TTE in acute Q fever patients offers a unique opportunity for early diagnosis of acute Q fever endocarditis and for the prevention of persistent endocarditis. Transesophageal echocardiography should be proposed in men, aged >40 years, with anticardiolipin antibodies >60 GPLU when TTE is inconclusive or negative.
Japanese student writers’ perspectives on anonymous peer review
Authors: Kim Sugene 
Published: February 2019

Abstract
This article explores Japanese EFL learners’ perceptions of face-to-face vs. anonymous peer review in a writing classroom. Albeit few in number, some studies claim that Asian students exhibit difficulty in providing negative feedback because they tend to be hesitant for cultural reasons to criticize others’ work. To verify and extend such observations, this study collected data from 64 Japanese college students regarding their experiences and perspectives after they performed peer review in both conditions. Analysis of the data collected through a survey and semi-structured interviews did not support the previously held views that learners from non-Western cultural backgrounds are predisposed to be reluctant peer reviewers. Further, the findings indicated that Japanese EFL learners’ preference for a specific peer-review mode interacts closely with various factors. Possible pedagogical implications are discussed in relation to ways to better implement peer-review sessions.
Development and usability testing of an audit and feedback tool for anesthesiologists
Authors: Barbeito Atilio , Segall Noa 
Published: February 2019

AbstractBackgroundWe describe the creation and evaluation of a personal audit and feedback (A&F) tool for anesthesiologists.MethodsA survey aimed at capturing barriers for personal improvement efforts and feedback preferences was administered to attending anesthesiologists. The results informed the design and implementation of 4 dashboards that display information on individual practice characteristics as well as comparative performance on several quality metrics. The dashboards’ usability was then tested using the human-centered design framework.ResultsAnesthesiologists listed lack of information on current practice as the main barrier for improvement. Regarding usability, participants gave the dashboards an average score of 3.8 (scale 1–5) on consistency, learnability, and information organization, and performed the assigned tasks well, with an average score of 89% (range 79–100%).ConclusionsWe describe the design, implementation, and usability testing of an innovative tool that utilizes data derived from the electronic health record (EHR) system to provide A&F to anesthesiology providers.
NUMB regulates the endocytosis and activity of the anaplastic lymphoma kinase in an isoform-specific manner
Authors: Wei Ran , Liu Xuguang , Voss Courtney , Qin Wentao , Dagnino Lina , Li Lei , Vigny Marc , Li Shawn Shun-Cheng 
Published: February 2019

Abstract
NUMB is an evolutionarily conserved protein that plays an important role in cell adhesion, migration, polarity, and cell fate determination. It has also been shown to play a role in the pathogenesis of certain cancers, although it remains controversial whether NUMB functions as an oncoprotein or tumor suppressor. Here, we show that NUMB binds to anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase aberrantly activated in several forms of cancer, and this interaction regulates the endocytosis and activity of ALK. Intriguingly, the function of the NUMB–ALK interaction is isoform-dependent. While both p66-NUMB and p72-NUMB isoforms are capable of mediating the endocytosis of ALK, the former directs ALK to the lysosomal degradation pathway, thus decreasing the overall ALK level and the downstream MAP kinase signal. In contrast, the p72-NUMB isoform promotes ALK recycling back to the plasma membrane, thereby maintaining the kinase in its active state. Our work sheds light on the controversial role of different isoforms of NUMB in tumorigenesis and provides mechanistic insight into ALK regulation.
Recent developments and future directions in adult lower-grade gliomas: Society for Neuro-Oncology (SNO) and European Association of Neuro-Oncology (EANO) consensus
Authors: Schiff David , Van den Bent Martin , Vogelbaum Michael A , Wick Wolfgang , Miller C Ryan , Taphoorn Martin , Pope Whitney , Brown Paul D , Platten Michael , Jalali Rakesh , Armstrong Terri , Wen Patrick Y 
Published: February 2019

Abstract
The finding that most grades II and III gliomas harbor isocitrate dehydrogenase (IDH) mutations conveying a relatively favorable and fairly similar prognosis in both tumor grades highlights that these tumors represent a fundamentally different entity from IDH wild-type gliomas exemplified in most glioblastoma. Herein we review the most recent developments in molecular neuropathology leading to reclassification of these tumors based upon IDH and 1p/19q status, as well as the potential roles of methylation profiling and deletional analysis of cyclin-dependent kinase inhibitor 2A and 2B. We discuss the epidemiology, clinical manifestations, benefit of surgical resection, and neuroimaging features of lower-grade gliomas as they relate to molecular subtype, including advanced imaging techniques such as 2-hydroxyglutarate magnetic resonance spectroscopy and amino acid PET scanning. Recent, ongoing, and planned studies of radiation therapy and both cytotoxic and targeted chemotherapies are summarized, including both small molecule and immunotherapy approaches specifically targeting the mutant IDH protein.