bluuebunny/crossref_metadata_2025_split huggingface dataset:
Career Motivators for Community Pediatric Hospitalists
Authors: Jackson Kelsey , Marek Rachel , Fromme H. Barrett 
Published: October 2019

BACKGROUND AND OBJECTIVES:
Within the field of pediatric hospital medicine, physicians can choose to work at community-based or university-based centers. The factors that motivate pediatric hospitalists to work specifically at community sites have not yet been fully explored. Our objective with this study was to elucidate the motivators for pediatric hospitalists to begin and continue work at community sites.

METHODS:
A qualitative study was performed via phone-based focus groups. Physicians were included if they were able to attend 1 of the offered group sessions and they self-identified as spending the majority of their time working as community-based pediatric hospitalists. Data were analyzed through a constant comparative analysis.

RESULTS:
Five themes emerged regarding factors that motivate pediatricians to begin and continue their careers as hospitalists in the community. The themes were (1) professional impact, (2) scope of practice, (3) personal and professional satisfaction, (4) community involvement, and (5) job availability.

CONCLUSIONS:
This study reveals the key factors that motivate community pediatric hospitalists to begin and continue working in the community.
Ivabradine therapy effectiveness in patients with chronic heart failure, Functional Class III
Authors: Kanorskiy S. G. , Tregubov V. G. , Pokrovskiy V. M. 
Published: October 2019

Aim. To assess the effectiveness of ivabradine-including therapy, as well as the effects of ivabradine on regulatoryadaptive status (RAS), in patients with chronic heart failure (CHF), Functional Class (FC) III. Material and methods. The study included 100 patients with FC III CHF and coronary heart disease (CHD) and/ or Stage III arterial hypertension (AH). The participants were previously prescribed a complex treatment regime. After randomisation, Group I included 56 patients (mean age 62,9±1,8 years), who were additionally administered metoprolol succinate extended-release (mean dose 59,1±4,5 mg/day). Group II (n=44; mean age 59,4±1,3 years) was additionally administered an If channel inhibitor ivabradine, when beta-adrenoblocker (BAB) therapy was not possible. At baseline and 6 months later, participants underwent treadmill test (with VO2max assessment), echocardiography, 24-hour blood pressure monitoring, and the measurement of plasma levels of N-terminal probrain natriuretic peptide (NT-proBNP). RAS status was qualitatively assessed in a cardio-respiratory synchronism test. Results. Ivabradine-including therapy improved myocardial structure and function, increased exercise capacity, and demonstrated positive effects on plasma NT-proBNP levels, VO2мах during treadmill test, and RAS status.Conclusion. Ivabradine could be an alternative medication when BAB therapy is not possible in patients with FC III CHF and CHD and/or Stage III AH.
Real-World Delivery of Rucaparib to Patients with Ovarian Cancer: Recommendations Based on an Integrated Safety Analysis of ARIEL2 and Study 10
Authors: Drew Yvette , Kristeleit Rebecca S. , Oaknin Ana , Ray-Coquard Isabelle , Haris Noor Md. , Swisher Elizabeth M. 
Published: October 2019

Abstract

Treatment options for women with recurrent ovarian cancer who have received two or more prior lines of chemotherapy have recently expanded with the U.S. Food and Drug Administration (FDA) and European Commission (EC) approvals of the poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib. As more oncologists begin to use rucaparib and other PARP inhibitors as part of routine clinical practice, awareness of possible side effects and how to adequately manage toxicities is crucial. In this review, we summarize the safety and tolerability of rucaparib reported in an integrated safety analysis that supported the FDA's initial approval of rucaparib in the treatment setting. Additionally, drawing on clinical data and our personal experience with rucaparib, we provide our recommendations on the management of common side effects observed with rucaparib, including anemia, blood creatinine elevations, alanine aminotransferase and aspartate aminotransferase elevations, thrombocytopenia, gastrointestinal-related events (e.g., nausea, vomiting), and asthenia and fatigue. These side effects, many of which appear to be class effects of PARP inhibitors, are often self-limiting and can be managed with adequate interventions such as treatment interruption and/or dose reduction and the use of supportive therapies. Supportive therapies may include blood transfusions for patients with anemia, prophylactic medications to prevent nausea and vomiting, or behavioral interventions to mitigate fatigue. Understanding and appropriate management of potential side effects associated with rucaparib may allow patients with ovarian cancer to continue to benefit from rucaparib treatment.
Вуз, организация учебного процесса в нем: удовлетворенность и ожидания студентов
Authors: Луков Сергей Валерьевич 
Published: October 2019

<p>Статья представляет данные опроса студентов Московского гуманитарного университета, проведенного в феврале — марте 2019 г. Опрос составлял обязательную часть государственной аккредитации вуза по разработанным в Рособрнадзоре инструментариям и был направлен на выявление удовлетворенности обучающихся вузом, качеством образования в нем. Хотя опрос такого рода не является эмпирическим социологическим исследованием, его данные могут быть использованы в социологии молодежи, социологии образования и т. д. для вторичного анализа данных. Показано, что недостатки инструментария (отсутствие социально-демографи­ческого блока, отнесение одной шкалы к двум вопросам, неполнота шкал) в этом случае чаще всего не мешают при сопоставлении данных внутри опроса (с учетом разницы в направлениях подготовки) и вне его (имея в виду данные других опросов) использовать этот массив в аспекте выявления удовлетворенностей и ожиданий.</p><p>Однако должен учитываться и Хоторнский эффект, который в этом случае связывается с идентификацией значительной части обучаемых со «своим» вузом, что несколько повышает (на 2–4%) показатели удовлетворенности им и его образовательными возможностями и деятельностью.<strong></strong></p>
Venous and Lung Thromboembolism in the Context of Lung Cancer: Clinical Manifestations, Risk Factors and Prognosis
Authors: Maia Rosana , Neves Inês , Morais António , Queiroga Henrique 
Published: October 2019

Introduction: The relationship between cancer and thromboembolic events has been known for a long time. Lung and venous thromboembolism are frequent complications of lung cancer and its treatment, being a great cause of morbidity and mortality. We pretend to establish the relationship between lung and venous thromboembolism and lung cancer, describe patient characteristics and analyze the impact in the survival and prognosis.Material and Methods: It was a retrospective study. All research subjects were selected from lung cancer patients with a newly diagnosed lung and venous thromboembolism event admitted to Hospital S. João, between January 2008 and December 2013 and were followed until December 2014. Statistical analysis was performed with SPSS.Results: From the search, we obtained 113 patients. The majority was male, smokers or ex-smokers, and adenocarcinoma was the most frequent histologic type, being diagnosed mostly in advanced stages. We noticed that the median time between lung cancer diagnosis and lung venous thromboembolism was 2.9 months. In 24 patients (21.4%), the lung cancer diagnosis occurred after the lung and venous thromboembolism event and in 86 patients (76.8%), it occurred before the event. After a median follow up of 1.4 months, 107 (94.7%) patients died, 1 (0.9%) was lost to follow-up and 5 (4.4%) were still alive. The median survival rate was 1.5 months.Discussion: The diagnosis of lung and venous thromboembolism in patients with lung cancer is associated with bad prognosis. It occurs most frequently in patients with advanced disease, in the first months after lung cancer diagnosis and after beginning chemotherapy.Conclusion: Disease progression is an independent predictor with negative impact in overall survival.
Doença de Parkinson: Revisão Clínica e Atualização
Authors: Cabreira Verónica , Massano João 
Published: October 2019

A doença de Parkinson é a segunda doença neurodegenerativa mais comum, tendo sido documentado um aumento significativo da sua prevalência nas últimas três décadas. A fisiopatologia da doença assenta numa interação genética-ambiente, estimando-se que cerca de 5% – 10% dos casos tenham causa genética monogénica. O diagnóstico é clínico, apoiado por investigação complementar adequada. Não dispomos ainda de uma forma de diagnosticar com certeza a doença de Parkinson in vivo, à exceção de testes genéticos em circunstâncias específicas, cuja utilidade é limitada a uma minoria de casos. Recentemente foram propostos novos critérios de diagnóstico, com o objetivo de melhorar a acuidade diagnóstica, com ênfase nas características que apontam para outras causas de parkinsonismo. As opções terapêuticas atualmente disponíveis são clinicamente úteis, pois têm a capacidade de melhorar os sintomas da doença e a qualidade de vida dos doentes. Após a introdução da levodopa, a estimulação cerebral profunda surgiu, mais recentemente, como a segunda intervenção terapêutica com importante impacto sintomático no tratamento desta doença. Os sintomas não motores e as complicações motoras são responsáveis por uma parte considerável da incapacidade na doença de Parkinson, pelo que devem ser identificados e tratados. A investigação científica atual foca-se na identificação de potenciais biomarcadores da doença, que permitam alcançar um diagnóstico certeiro e atempado, e na criação de terapêuticas mais eficazes, de modo a preencher as necessidades clínicas atualmente não satisfeitas. Este artigo apresenta uma revisão atualizada sobre a doença de Parkinson, guiando o leitor através dos conceitos mais atualizados nesta temática, de forma a permitir a sua aplicação na prática clínica diária.
Editorial
Authors: Lara José Edson 
Published: October 2019

Prezado Leitor, É com imensa satisfação que oferecemos-lhe esta segunda Edição Extraordinária da Revista Gestão & Tecnologia. A primeira edição extraordinária, publicada em 2017, abordou o tema da Inovação Tecnológica. Esta Edição Especial aborda uma temática diversificada, publicando artigos procedentes de países do Oriente Médio, predominantemente do Irã.
The Effect of Breadfruit Leaf Flour (Artocarpus altilis) on Number of Blood Cells And Correlation Between Cholesterol Blood and Meat of Tegal Ducks 10 Weeks Age
Authors: Tugiyanti Elly , Susanti Emmy 
Published: October 2019

The purpose of this research was to know the effect of breadfruit leaves flour in feed to blood profile and correlation between cholesterol, HDL and LDL of blood with meat cholesterol of maleTegal duck of 10 weeks old. The material used was Day Old Duck of male Tegal duck as much as 120 heads with experimental research methods and Completely Randomized Design (CRD). There were 6 treatments: feed without breadfruit leaf powder, feed + breadfruit flour 3% / kg feed, feed + breadfruit flour 6% / kg feed, feed + breadfruit flour 9% / kg feed, feed + flour breadfruit 12% / kg feed, and feed + breadfruit flour 15% / kg feed. Each treatment was repeated 5 times and each replication consisted of 4 ducks. The variables observed were the number of red blood cells, white blood cells, HDL, LDL, blood triglycerides, correlation between cholesterol, HDL and LDL blood with meat cholesterol of male Tegal duck of 10 weeks old. The result of the analysis showed that the supplementation of breadfruit leaves has significant effect (P <0,05) on the number of red blood cells, white blood cells, HDL, and blood triglyceride. There is a positive correlation between blood cholesterol with duck meat cholesterol which given breadfruit leaf powder. This research can be concluded that the supplementation of breadfruit leaf powder (Artocarpus altilis) can increase the number of red blood cells, white blood cells, blood HDL level but lowers blood cholesterol and triglyceride blood of male Tegal duck of 10 weeks old. Cholesterol meat is affected by blood cholesterol with regression coefficient of 0.780941, influenced by LDL (r = 0.407849), but negatively affected by HDL (r = -0.47022).
In Vitro Evaluation of Hen Eggshells Addition in Rice Husk on Litter Properties
Authors: Afnan Rudi , Idana Danar Bias , Yani Ahmad 
Published: October 2019

Abstract. Ammonium (NH3) is released from uric acid of chicken feces. Good management practices are required to depress ammonium concentration in a litter. Several research findings showed that application of CaCO3 (calcium carbonate) can decrease ammonium concentration in a litter. Eggshell as a by-product of hennery (hen stable) and hatchery is mainly constructed from CaCO3. This research aimed to evaluate the addition of hen eggshell powder at different concentration in litter on water content, pH, microorganism, and NH3 concentration of litter. Rice husk as litter material, hen eggshell powder at a concentration of 0%, 5%, 10%, and 15% and hen manure were thoroughly mixed. After 24 hours, the concentration of water content, pH, microorganisms amount and NH3 in each treatment were measured. This research was completely randomized designed with 3 repetitions. Results showed the progressive addition of hen eggshell powder in litter until 15% increased pH and decreased water content, number of microorganisms and NH3 concentration. The addition of 15% hen eggshell powder in litter revealed best litter properties.Keywords: ammonium, hen eggshell, litter, pH, water content
Traumatic Pediatric Quadriceps Rupture After Medial Patellofemoral Ligament Reconstruction
Authors: Cannamela Peter C. , Maak Travis G , Adeyemi Temitope F. , Aoki Stephen K. 
Published: October 2019

Case:
A healthy 14-year-old boy, who presented with recurrent patellar instability, underwent medial patellofemoral ligament (MPFL) reconstruction. Four weeks following this operation, the patient slipped and fell while wearing his knee brace and was found to have sustained a quadriceps tendon rupture.

Conclusions:
We present a case of a rare, previously undescribed complication following an MPFL reconstruction in a young athlete. The etiology of this particular injury pattern may be due to a disruption of the vascular supply to the superior pole of the patella. Orthopaedic surgeons performing these reconstructions should be aware of this unusual complication.
Implementation the Multilateral Wells With ICDs for Development of Formations With High Viscosity Oil and Underlying Water Zone
Authors: Sleptsov Dmitriy , Ishimov Ivan , Golovatskiy Yury , Mezhnova Natalia 
Published: October 2019

Abstract
Vertical wells drilling for development of viscous oil in formations with low oil saturated thickness and underlying water zone, usually has a poor economics due to fast water breakthrough (water coning). The wells with 300 - 400m horizontal sections with a dense placing are able to achieve high recovery factor, but have a limitations during drilling and completion and subsequent production management.
The paper discusses the results of pilot works on the multilateral well construction in a highly viscous oil field with underlying water. The well designed especially for development producing intervals of bobrikovsky formation, widespread in a Volga-Ural region of Russia.
Based on detailed 3D geological model of the reservoir a well with three laterals was designed, equipped with inflow control devices (ICD) with sliding sleeves to enable isolation of each wellbore. The well has high horizontal sweep efficiency with a possibility to fully manage the inflow from every lateral in case of water breakthrough.
Using while drilling the deep azimuthal resistivity measurement tool allowed placing the wellbores in the top of pay zone far from water contact. According to the LWD measurements, the proper ICDs parameters were determined before well completion in order to equalize the inflow profile of the horizontal section. A significant increase in productivity and cumulative oil production of multilaterals allow to reduce wells density and ensure economic efficiency, even despite the increase in costs compared to horizontal well.
Tight Oil Development in RN-Yuganskneftegas
Authors: Shabalin Maksim , Khabibullin Galiaskar , Suleymanov Eldar , Rodionova Inessa , Sergeychev Andrey , Kulbaeva Diana , Volkova Polina , Serbaeva Alina 
Published: October 2019

Abstract
This paper presents a way of tight oil development using horizontal wells with hydraulic fracturing and modified field development patterns.
In order to minimize risks of drilling and optimize development decisions we apply systematic complex approach including well data analysis (incl. special tests), seismic data, reservoir surveillance results and geology modeling based on lithofacial analysis followed by simulation study. The feature of this approach is that this workflow is carried out on an ongoing basis and adjusted to the new incoming data. Using Achimov and Tyumen formation as examples characterized by high lithofacial heterogeneity and complexity of technological indicator forecasting we presented approaches to design the development strategy based on scientific and engineering support and pilot data.
A New Page in Completion of Sidetrack Wells with Multistage Fracturing: The First Application of Cemented Ball Activated Frac Sleeves
Authors: Morauskas Robert G. , Koltypin Oleg A. , Matveev Dmitry N. , Nurtdinov Denis M. , Osipov Dmitry A. , Napolskikh Eugene A. , Simankovich Andrey Y. , Shahbazov Kamil R. , Protsenko Vladislav G. 
Published: October 2019

Abstract
In recent years, more attention has been turning towards the tight reservoirs. Therefore, completion configurations with multi-stage hydraulic fracturing take a special place in available technology toolbox.
The widely spread multistage hydrofracturing in sidetracks (with collar cementing) has the following technological flaws: a long well reconstruction cycle; restrictions related to placing annular packers; possible leakage of the cement collar; failure to reach the target depth with the liner due a multitude of elements involved.
Moreover, the current way of work organization and the current state of technology makes it hard to achieve shorter sidetracking and hydrofrackturing cycles without changing the completion design. To solve these problems, a fundamentally new approach was introduced - to combine the advantages of continuous cementing and ball activated MSHF completion systems.
One of the Russian companies has developed the equipment required. A number of stand tests were carried out after the manufacturing that confirmed the design feasibility.
During the project implementation, a risk assessment exercise was performed for drilling and completion jobs, as well as for the multi-stage hydraulic fracturing, whereupon risk mitigation and exclusion measures were identified. As a result, the cementing program was significantly revised, considering the special nature of the work ahead.
Based on the results of the project, wells with horizontal sidetracks and continuous cement completions for subsequent MSHF (not used before in the Company) were successfully reconstructed. Due to an integrated approach and close interaction of all stakeholders already at the early stage of equipment testing and prior to the project implementation, it was possible to successfully finalize the installation and cementing of the completion systems.
Subsequently, the successful completion job ensured uninterrupted MSHF operations in the cemented liner.
Managed Pressure Drilling Overcomes Drilling Challenges and Enhances Oil Production of Naturally Fractured Carbonate Reservoir of East Siberia
Authors: Kurbanov Vasif , Rotaru Anna , Gribanov Vasiliy , Bakhitov Rinat , Sidorov Yuliy 
Published: October 2019

Abstract
One of the main problems associated with drilling of the horizontal wells of high length under conditions of a low-porous carbonate fractured reservoir is catastrophic mud losses associated with zones of intense fracturing and cavernousness. The meeting of such zones leads to the risk of failure to achieve the project well length, which further negatively affects the reserves development. This article describes the technological, production, economic aspects of the introduction of managed pressure drilling (MPD).
Managed Pressure Drilling (MPD) is an adaptive drilling process used to precise control the annular pressure profile throughout the wellbore. While conventional drilling uses the hydrostatic pressure of the drilling mud to manage pressure in the well, MPD uses a combination of surface pressure, hydrostatic pressure of the mud and annular friction to balance the exposed formation pressure. Control of these parameters allows maintaining the pressure at the bottom of the well close to the reservoir pressure, thereby avoiding mud losses or inflow of formation fluid into the well.
Conventional drilling of highly fractured zone is accompanied with intensive mud losses. Over 50% of the drilled wells in the oilfield could not reach the final target. Average productivity index for short wells is 30% less than for those that reached planned horizontal length. Application of bridging agents and hi-vis pills partially allows to solve the problem, but negatively affects the productivity and cost of wells.
As part of pilot stage, managed pressure drilling was tested on the two well clusters. 5 wells out of 7 reached the project length. The increase in the starting oil rate was 30%. The loss of drilling mud has significantly decreased. The average mechanical rate of penetration increased by 7%. Despite the high cost of the MPD, the ability to control the well during drilling reduces the final cost of the well by minimizing the loss of oil required to prepare the drilling fluid. According to the analyzed wells, the average cost of a meter of penetration for MPD is 14% higher than with standard overbalance drilling. At the same time, the unit cost of drilling per one ton of oil flow rate decreased by 22%, which indicates the economic feasibility of the technology.
The paper presents a comprehensive analysis of the MPD, with an assessment of the impact on drilling performance (rate of penetration, mud loses), production characteristics of wells (starting production rate, productivity index) and economic effect (cost of 1m penetration).
Adaptable Drilling Fluid System Assisted in Successful Drilling of TAML 2 Nine-Hole Horizontal Well in Vankor Field
Authors: Lezin A. , Kharitonov A. , Seminikhin I. , Korsunov E. , Gassan A. , Tikhonov E. , Jadan G. , Stashko V. , Blagonadeshniy I. , Manikhin A. , Medvedev S. 
Published: October 2019

Abstract
Currently, part of the Eastern Siberia fields is transforming to the latest step of the extraction process by slowly depleting the payzone with intensive production and turning it into an unconventional resources oilfield. In such a case, formation drilling fluid quality is part of the initial plan. Traditional drilling methods with only one horizontal borehole no longer achieves targets in unconventional oil and gas production. Drilling multilateral wells captures all oil-bearing layers in the production target area, not just content from an edge formation from the perspective of conventional drilling. A non-damaging in-situ formation drilling fluid was developed for use in the Vankor oilfield, the top priority oilfield for Rosneft in Eastern Siberia. Production drilling was started in 2006 and a growing rate of drilling is increasing each year by up to 15-20%, which is the one of the largest across Russia. The paper fully describes the methods of drilling fluid selection, the evaluation of mud formulation, the laboratory study with cutting and cores, and the economic effects on the oilfield with drilling of multilateral sections in the Vankor oilfield.