bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modified delivery of SAPIEN 3 valve in the pulmonary position: Evolution of technique or dire need?
Authors: Shahanavaz Shabana , Rockefeller Toby , Nicolas Ramzi , Balzer David 
Published: November 2018

AbstractTranscatheter pulmonary valve replacement (TPVR) is now common practice in patients with significant pulmonary regurgitation (PR), stenosis (PS), or mixed pulmonary valve disease. While the Melody valve (Medtronic, Inc.) and its delivery system were specifically designed for use in the right ventricular outflow tract (RVOT), Sapien valves (XT and S3, Edwards Lifesciences, Inc.) and their delivery systems (Novaflex and Commander) were not. As a result, placement of Sapien valves in the RVOT can be challenging secondary to the stiffness of the current delivery system. Manipulating a stiff delivery system within the RV also introduces risk to the tricuspid valve and its chordal attachments. We report a novel delivery technique for the Sapien S3 valve which has greatly simplified valve delivery into the RVOT and may potentially reduce the risk of tricuspid valve injury.
Cu−Ni−Al Spinel Oxide as an Efficient Durable Catalyst for Methanol Steam Reforming
Authors: Liu Yajie , Qing Shaojun , Hou Xiaoning , Qin Fajie , Wang Xiang , Gao Zhixian , Xiang Hongwei 
Published: November 2018

AbstractCopper metal catalysts suffer from gradual loss of activity due to the agglomeration and sintering of active metals during the catalytic reaction processes. Herein, we show that enhanced catalytic durability for methanol steam reforming (MSR) can be achieved by using Ni modified Cu−Al spinel solid solution as catalysts without pre‐reduction treatment. In so doing, Cu atoms can be gradually released from spinel structure after the initiating of reaction by non‐spinel CuO entities. Incorporation of Ni in the spinel structure reveals two positive effects: slowing down the Cu releasing rate and producing even smaller Cu nanoparticles as compared to that of Cu−Al spinel. Since Ni2+ ions in spinel framework cannot be reduced during the catalytic process, we suggest that the remaining defective CuaNib□cAldO4 spinel structure plays a crucial role in stabilizing the formed Cu nanoparticles. The synthesized sample with 0.05 mol Ni per mol Cu shows the best catalytic performance as demonstrated by pretty stable activity during the long‐term catalytic testing up to 2000 h. The findings show great commercial application potentials for the production of H2 from MSR.
Single‐Sided Competitive Axial Coordination of G‐Quadruplex/Hemin as Molecular Switch for Imaging Intracellular Nitric Oxide
Authors: Zhang Lei , Zhou Jun , Ma Fengjiao , Wang Quanbo , Xu Hui , Ju Huangxian , Lei Jianping 
Published: November 2018

AbstractAxial coordination is a crucial biological process to regulate biomolecules’ functions in natural enzymes. However, it is a great challenge to determine the single or dual axial interaction between the metal center of enzymes and the ligand. In this work, a controllable axial coordination system was developed based on G‐quadruplex/hemin complex by designing a series of fluorescent derivatives. The mechanism on axial coordination of G‐quadruplex/hemin with coumarin‐imidazole ligands was proposed to be single‐sided, and led to fluorescence quenching of ligands. Upon addition of nitric oxide, the fluorescence of ligands was recovered through competitive axial coordination, providing a “signal on” strategy for signal transduction. More significantly, the fluorescent imaging of intracellular nitric oxide was achieved after conjugating with gold nanoparticles. Also, the proposed protocol provided a smart strategy to monitor the relationship between nitric oxide and p53 protein activity in living cells.
Ce(IO3)2F2⋅H2O: The First Rare‐Earth‐Metal Iodate Fluoride with Large Second Harmonic Generation Response
Authors: Abudouwufu Tushagu , Zhang Min , Cheng Shichao , Yang Zhihua , Pan Shilie 
Published: November 2018

AbstractThe first rare earth metal iodate fluoride, Ce(IO3)2F2⋅H2O, was synthesized by a hydrothermal method. In the structure, CeO5F4 polyhedra connect with isolated IO3 groups to form 1D infinite
[Ce(IO3)2F2] chains, which interconnect with each other by weak hydrogen bonds to construct the whole structure. Ce(IO3)2F2⋅H2O produces a large second harmonic generation response, which is three times that of potassium dihydrogenphosphate. Theoretical calculations with DFT and dipole moments were performed to illustrate the relationships between the structure and the properties. The results show that Ce(IO3)2F2⋅H2O is a new iodate fluoride with novel structure and potential applications in nonlinear optics.
A High‐Pressure Praseodymium Fluoride Borate Linking Multiple Structural Features of Apatite‐Type Compounds
Authors: Glätzle Matthias , Pitscheider Almut , Oeckler Oliver , Wurst Klaus , Huppertz Hubert 
Published: November 2018

AbstractPr5(BO4)3−x(BO3)x(F,OH)2.67O0.28 (x≈1.6), a boron‐containing fluoride‐oxoapatite‐like compound, was obtained by the application of high‐pressure/high‐temperature synthesis. It exhibits a superstructure of the apatite type with a tripled c lattice parameter (space group P63/m) and shows complex anion disorder along the 63 screw axis and occupation of distorted octahedra, as well as almost trigonal planar sites, by oxygen and fluorine atoms. Furthermore, a distinct BO4/(BO3+F) group disorder is found; 46 % of the sites being occupied by BO4 groups and 54 % by BO3 groups, with a fluoride ion located near the missing oxygen atom. The rare earth cations in the 4f sites exhibit a specific distorted tricapped trigonal prismatic coordination with a mean metaprism twist angle of 21.3°. The crystal structure of Pr5(BO4)3−x(BO3)x(F,OH)2.67O0.28 (x≈1.6) shows much “flexibility” resulting in split and off‐site positions of all other rare earth cations. The title compound therefore combines many structural features of apatite‐like compounds, for example biologically highly‐important carbonated apatites, shedding more light onto the complex structural chemistry of apatites.
Structural and Kinetic Profiling of Allosteric Modulation of Duplex DNA Induced by DNA‐Binding Polyamide Analogues
Authors: Aman Khalid , Padroni Giacomo , Parkinson John A. , Welte Thomas , Burley Glenn A. 
Published: November 2018

AbstractA combined structural and quantitative biophysical profile of the DNA binding affinity, kinetics and sequence‐selectivity of hairpin polyamide analogues is described. DNA duplexes containing either target polyamide binding sites or mismatch sequences are immobilized on a microelectrode surface. Quantitation of the DNA binding profile of polyamides containing N‐terminal 1‐alkylimidazole (Im) units exhibit picomolar binding affinities for their target sequences, whereas 5‐alkylthiazole (Nt) units are an order of magnitude lower (low nanomolar). Comparative NMR structural analyses of the polyamide series shows that the steric bulk distal to the DNA‐binding face of the hairpin iPr‐Nt polyamide plays an influential role in the allosteric modulation of the overall DNA duplex structure. This combined kinetic and structural study provides a foundation to develop next‐generation hairpin designs where the DNA‐binding profile of polyamides is reconciled with their physicochemical properties.
Koenigs–Knorr Glycosylation Reaction Catalyzed by Trimethylsilyl Trifluoromethanesulfonate
Authors: Singh Yashapal , Demchenko Alexei V. 
Published: November 2018

AbstractThe discovery that traditional silver(I)‐oxide‐promoted glycosidations of glycosyl bromides (Koenigs–Knorr reaction) can be greatly accelerated in the presence of catalytic trimethylsilyl trifluoromethanesulfonate (TMSOTf) is reported. The reaction conditions are very mild that allowed for maintaining a practically neutral pH and, at the same time, providing high rates and excellent glycosylation yields. In addition, unusual reactivity trends among a series of differentially protected glycosyl bromides were documented. In particular, benzoylated α‐bromides were much more reactive than their benzylated counterparts under these conditions.
Catalytic Generation and Chemoselective Transfer of Nucleophilic Hydrides from Dihydrogen
Authors: Pape Felix , Brechmann Lea T. , Teichert Johannes F. 
Published: November 2018

AbstractCopper(I)–N‐heterocyclic‐carbene (NHC) complexes enabled the catalytic generation of nucleophilic hydrides from dihydrogen (H2) and their subsequent transfer to allylic chlorides. The highly chemoselective catalyst displayed no concomitant hydrogenation reactivity; in fact, the terminal double bond formed in the hydride transfer remained intact. Switching to deuterium gas (D2) allowed for regioselective monodeuteration with excellent isotope incorporation.
Synaptic distributions of pS214‐tau in rhesus monkey prefrontal cortex are associated with spine density, but not with cognitive decline
Authors: Crimins Johanna L. , Puri Rishi , Calakos Katina C. , Yuk Frank , Janssen William G. M. , Hara Yuko , Rapp Peter R. , Morrison John H. 
Published: November 2018

AbstractFemale rhesus monkeys and women are subject to age‐ and menopause‐related deficits in working memory, an executive function mediated by the dorsolateral prefrontal cortex (dlPFC). Long‐term cyclic administration of 17β‐estradiol improves working memory, and restores highly plastic axospinous synapses within layer III dlPFC of aged ovariectomized monkeys. In this study, we tested the hypothesis that synaptic distributions of tau protein phosphorylated at serine 214 (pS214‐tau) are altered with age or estradiol treatment, and couple to working memory performance. First, ovariectormized young and aged monkeys received vehicle or estradiol treatment, and were tested on the delayed response (DR) test of working memory. Serial section electron microscopic immunocytochemistry was then performed to quantitatively assess the subcellular synaptic distributions of pS214‐tau. Overall, the majority of synapses contained pS214‐tau immunogold particles, which were predominantly localized to the cytoplasm of axon terminals. pS214‐tau was also abundant within synaptic and cytoplasmic domains of dendritic spines. The density of pS214‐tau immunogold within the active zone, cytoplasmic, and plasmalemmal domains of axon terminals, and subjacent to the postsynaptic density within the subsynaptic domains of dendritic spines, were each reduced with age. None of the variables examined were directly linked to cognitive status, but a high density of pS214‐tau immunogold particles within presynaptic cytoplasmic and plasmalemmal domains, and within postsynaptic subsynaptic and plasmalemmal domains, accompanied high synapse density. Together, these data support a possible physiological, rather than pathological, role for pS214‐tau in the modulation of synaptic morphology in monkey dlPFC.
Investigation of RNA‐RNA Interactions Using the RISE Database
Authors: Ju Yanyan , Gong Jing , Yang Yucheng T. , Zhang Qiangfeng Cliff 
Published: November 2018

AbstractRNA‐RNA interactions (RRIs) are essential to understanding the regulatory mechanisms of RNAs. Mapping RRIs in vivo in a transcriptome‐wide manner remained challenging until the recent development of several sequencing‐based technologies. However, RRIs generated from large‐scale studies had not been systematically collected and analyzed before. This article introduces RISE, a database of the RNA Interactome from Sequencing Experiments. RISE provides a comprehensive collection of RRIs in human, mouse, and yeast, derived from transcriptome‐wide sequencing experiments, as well as targeted sequencing studies and other public databases/datasets. To facilitate better understanding of the biological roles of these RRIs, RISE also offers rich functional annotations involving RNAs, and an interactive interface to explore the analysis results. Here, we provide a brief description of the RISE website and a step‐by‐step protocol for using RISE to study RRIs. © 2018 by John Wiley & Sons, Inc.
A novel high speed Artificial Neural Network–based chaotic True Random Number Generator on Field Programmable Gate Array
Authors: Alcin Murat , Koyuncu Ismail , Tuna Murat , Varan Metin , Pehlivan Ihsan 
Published: November 2018

SummaryIt is well observed that cryptographic applications have great challenges in guaranteeing high security as well as high throughput. Artificial neural network (ANN)–based chaotic true random number generator (TRNG) structure has not been unprecedented in current literature. This paper provides a novel type of high‐speed TRNG based on chaos and ANN implemented in a Xilinx field‐programmable gate array (FPGA) chip. The paper consists of two main parts. In the first part, chaos analyses of Pehlivan‐Uyaroglu_2010 chaotic system (PUCS) have been accomplished to prove that PUCS operates in chaotic regime. So PUCS can be an efficient alternative to the entropy source for classical TRNGs. In the second part, the hardware design of the proposed TRNG has been created using VHDL in Xilinx platform. As a result, the implemented TRNG offers throughput up to 115.794 Mbps. Besides, the generated random numbers have been tested with the FIPS 140‐1 and NIST 800.22 test suites. The high quality of generated true random numbers have been confirmed by passing all randomness tests. The results have shown that the proposed system can provide not only high throughput but also high quality random bit sequences for a wide variety of embedded cryptographic applications.
Traffic pattern–based load‐balancing algorithm in software‐defined network using distributed controllers
Authors: Gasmelseed Hatim , Ramar Ramalakshmi 
Published: November 2018

SummaryProgrammability and decoupling of the data plane and control plane in software‐defined networking (SDN) make the enterprise's network to focus on this new paradigm and to deploy their applications on it. Furthermore, supporting of distributed controllers in SDN opens the opportunities to address the limitations of centralized controller's architecture, which in turn improves the overall performance of the network. This study proposes a new load‐balancing algorithm to handle the load based on the traffic pattern specifically transmission control protocol (TCP) and user datagram protocol (UDP) traffic. Additionally, this study uses a distributed SDN controller's architecture to host the load balancer application. This study also employs a failover mechanism on the distributed architecture to achieve high‐availability environment and to ensure the redundancy and reliability of the network. The obtained results prove the effectiveness of the proposed algorithm in terms of availability, which is increased by 11%, response time is reduced by 98%, transaction rate is also increased by 258%, throughput is increased by 206%, concurrency is reduced by 63%, and packet loss is reduced by 86% while comparing with random, round‐robin, and weighted round‐robin algorithms in addition to ease the integration and deployment in distributed controllers.
Statistical methods and reporting practices in the study of dyslexia
Authors: Rollins Adam , Oslund Eric L. , Wallace Kelli , Li Daren 
Published: November 2018

This report presents findings from a review of the journals Dyslexia and Annals of Dyslexia over a 10‐year period from 2005 to 2014. Three hundred articles were reviewed to examine statistical methodology and reporting practices. Articles were coded according to their reported covariates, effect sizes, and statistical methods. In addition, trends were examined in relation to the 2008 release of the What Works Clearinghouse Procedures and Standards Handbook from the Institute of Education Sciences in order to evaluate any potential impact of recommended practices. We found an increase in prevalence of specific statistical methods as well as increases in reporting of effect sizes following publication of the handbook. The reporting of effect sizes statistically significantly increased following publication of the manual (55% prepublication vs. 72% post‐publication). The use of analysis of variance increased post‐publication, whereas articles using no statistical methods or descriptives only decreased. Approximately one third of articles included covariates in their analysis; inclusion of covariates was consistent from prepublication to post‐publication. Findings indicate that over the past 10 years, articles are becoming increasingly rigorous in methodology and reporting practices.
Microchip gel electrophoretic analysis of perchloric acid‐soluble serum proteins in systemic inflammatory disorders
Authors: Makszin Lilla , Kustán Péter , Szirmay Balázs , Páger Csilla , Mező Emerencia , Kalács Krisztina I. , Pászthy Vera , Györgyi Erzsébet , Kilár Ferenc , Ludány Andrea , Kőszegi Tamás 
Published: November 2018

AbstractPerchloric acid (PCA) precipitation is a well‐known method for the separation of heavily glycosylated proteins and for reducing the masking effect of major serum proteins. The aim of this study is to characterize PCA‐soluble serum proteins in healthy individuals and in patients with systemic inflammatory diseases, such as Crohn's disease and sepsis. A PCA precipitation protocol was prepared and adapted to the analytical methods. After PCA treatment of the serum, the soluble proteins in the supernatant were analyzed by SDS‐PAGE and by microchip gel electrophoresis (MGE). Characteristic changes of the electrophoretic patterns of the PCA‐soluble fractions were observed. Four characteristic bands (at ∼11, ∼65, ∼85, and ∼120 kDa) with varying intensity were detected by MGE. The proportion of the ∼65, ∼85, and ∼120 kDa bands were significantly higher in systemic inflammatory conditions than in healthy individuals (p < 0.001), and characteristic patterns were observed in patients with acute inflammation. The marked differences in the acid‐soluble protein patterns, which were observed in patients with ongoing systemic inflammation, might be a good indicator of inflammation. The MGE analysis is a fast screening and quantification method for the detection of characteristic changes among acid‐soluble serum proteins.
Evaluation of different microwave heating parameters on the pore structure of oil shale samples
Authors: Zhu Jingyi , Yang Zhaozhong , Li Xiaogang , Wang Nailu , Jia Min 
Published: November 2018

AbstractThe pore structure of oil shale during microwave heating significantly determines the flow behavior, the transformation products and the ultimate recovery regardless of ex situ retorting or in situ development methods. In this experimental study, the effects of microwave heating parameters including heating time, reaction temperature and output power on the heating behavior, surface morphology and pore roughness of oil shale were investigated based on the nitrogen adsorption/desorption and scanning electron microscope (SEM) experiments. Fractal dimension D1 and D2 (at relative pressures of 0‐0.5 and 0.5‐1, respectively) were calculated according to the fractal Frenkel‐Halsey‐Hill model. The relationships between specific surface area, cumulative pore volume, average pore diameter, and fractal dimension have been studied. The results demonstrated that the pore structure of oil shale was greatly influenced by microwave heating parameters due to the decomposition of kerogen, the internal pressure caused by the steam and volatiles, the complicated reactions and the thermal stress induced by microwave. Moreover, fractal dimension also changed correspondingly with different heating parameters. The variations of fractal dimension D1 was consistent with the evolvement of specific surface area and the changes in fractal dimension D2 showed negative correlation with average pore volume. The relationships between D1 and surface roughness, D2 and pore structure were verified based on the comparison of SEM images. The fractal theory is reliable to describe the surface morphology and pore structure of oil shale and thus supports the application of microwave heating on the oil shale development.
Politics and health outcomes: A path analytic approach
Authors: Cinaroglu Songul 
Published: November 2018

SummarySocial and health policies and political participation are associated with each political tradition related to public health outcomes. However, there is a lack of evidence for the relationship between policy and outcomes. This study seeks to determine the relationship between politics, labour and welfare state indicators, economic inequality, and health outcome indicators. Data to test the model was obtained from the Turkish Statistical Institute (TurkStat) that belongs to the 81 provinces of Turkey. Path analysis was used to model the associations between policy, labour and welfare states, economic inequality, and health outcomes. To test the goodness of fit of the model, multiple criteria of model fit indices were utilised. The fit of the respecified path analytic model data is good (normed fit index [NFI] is 0.91, comparative fit index [CFI] is 0.92, goodness of fit index [GFI] is 0.91, and adjusted goodness of fit index [AGFI] is 0.93). Study results illustrate a strong relationship between voter partisanship, employment rate, satisfaction from both social security and health services, and life expectancy at birth and mortality. These results represent an important step towards understanding the elusive relationship between policy and health outcomes. Designing socially inclusive policies, considering labour market opportunities, and enhancing the population's well‐being are advisable strategies for policymakers who wish to optimise public health outcomes.
A study of nurse‐based Injury Units in Ireland: An emergency care development for consideration worldwide
Authors: Wilson Donna M. , Devkota Rashmi 
Published: November 2018

SummaryThe aim of this 2018 research study was to determine why nurse‐based Injury Units were developed in Ireland and how they function in the Irish healthcare system, including what they contribute in relation to addressing the healthcare needs of Irish citizens. A document review was completed and interviews of nurse practitioners and physicians working in Irish Emergency Rooms (ERs) and Injury Units, as well as nurse managers with responsibility for Injury Units and health service executives who helped design Injury Units. A new model of emergency care was needed 20 years ago when two issues were apparent. The first was concern over unsafe care in small ERs as a result of low patient volumes and staff not having ER expertise. The second issue was long waits for ER care. Considerable opportunity for change was present, including financial imperatives and nurse, physician, and political leaders who were together ready to design and move a new‐to‐Ireland ER services model and nurse practitioner education forward. The Injury Unit model is based on nurse practitioners providing a defined set of services to nonurgent patients in daytime hours. This model was pilot tested and is being implemented across Ireland after it was determined that quality services were being rapidly and safely provided. Nurse practitioner education was also initiated and is now in expansion mode to gain 700 more nurse practitioners by the year 2021 over the current 240.