bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exclusions in social inclusion projects: Struggles in involving children in digital technology development
Authors: Iivari Netta , Kinnula Marianne , Molin‐Juustila Tonja , Kuure Leena 
Published: April 2018

AbstractWhile social inclusion projects have centred on digital technology for a long time now, they have remained silent about educating and empowering children to act as technology makers and shapers, not merely passive users. We have organized, together with children, digital technology projects that we now critically examine from the perspective of inclusion/exclusion. The paper shows that in social inclusion projects, there is exclusion taking place in a multitude of forms, shaped by a variety of rules and powers. We use nexus analysis as a theoretical and methodological tool that guides us to study inclusion/exclusion as processes, within which both discourses and concrete actions are to be acknowledged as well as historical and interactional aspects—both at individual level and at the level of social structures. Our study shows that inclusion and exclusion may be intentionally accomplished by children themselves, those may result without any intentional effort because of circumstances and those may also be done for children by various kinds of adults. Although children's empowerment and agency are significant, also adults play a decisive role. Implications for social inclusion and digital technology education research and practice are discussed. Nexus analysis is suggested as a useful means for revealing and managing the complexity involved in social inclusion/exclusion.
AmotP130 regulates Rho GTPase and decreases breast cancer cell mobility
Authors: Chen Zhe‐Ling , Yang Jiao , Shen Yan‐Wei , Li Shu‐Ting , Wang Xin , Lv Meng , Wang Bi‐Yuan , Li Pan , Zhao Wen , Qiu Rui‐Yue , Liu Yu , Liu Pei‐Jun , Yang Jin 
Published: April 2018

AbstractAngiomotin (Amot) is a newly discovered, multifunctional protein that is involved in cell migration and angiogenesis. However, the role of its isoform, AmotP130, in the regulation of cytoskeleton and metastasis of breast cancer, is unclear. The aim of this study was to investigate the role of AmotP130 in the reorganization of the actin cytoskeleton and the changes of morphology in breast cancer cells through the Rho pathway that influences the invasion and migration of cells. The results suggested that AmotP130 suppressed the invasion ability through remodelling the cytoskeleton of breast cancer cells, including the actin fibre organization and focal adhesion protein turnover. Global transcriptome changes in breast cancer cells following knockdown of AmotP130 identified pathways related with the cytoskeleton and cell motility that involved the Rho GTPase family. From database analyses, changes in the Rho GTPase family of proteins were identified as possible prognostic factors in patients with breast cancer. We have been suggested that AmotP130 suppressed the invasion ability through remodelling of the cytoskeleton of breast cancer cells, involving regulation of the Rho pathway. The cytoskeleton‐related pathway components may provide novel, clinically therapeutic targets for breast cancer treatment.
Effectiveness of a trauma‐focused group intervention for young refugees: a randomized controlled trial
Authors: Pfeiffer Elisa , Sachser Cedric , Rohlmann Friederike , Goldbeck Lutz 
Published: April 2018

BackgroundAs access to evidence‐based treatments for young refugees with posttraumatic stress symptoms (PTSS) is limited, we developed the trauma‐focused group intervention Mein Weg to be delivered by trained social workers. A recently published pilot study delivered preliminary evidence of the intervention with regard to symptom reduction and its feasibility. The aim of this study was, therefore, to determine whether the intervention, in addition to usual care (UC), is more effective in reducing PTSS (primary outcome) compared to UC alone.MethodsA parallel group randomized controlled trial was conducted in seven German child and adolescent welfare agencies. Participants were randomly assigned to either six sessions Mein Weg (n = 50; Mage = 17.00, 94% male) or UC (n = 49; Mage = 16.92, 92% male). Mixed effect models, with fixed effects of group and time as well as their interaction, were performed on the relevant outcome measures. This trial was registered in the German Clinical Trials Registry (#DRKS00010915, https://www.drks.de/drks_web/).ResultsIntention‐to‐treat analyses showed that Mein Weg was significantly superior to UC regarding symptom improvement of self‐reported PTSS (Mein Weg: d = .61, UC: d = .15) and depression (Mein Weg: d = .63, UC: d = −.06), but not regarding caregiver‐reported symptoms and self‐reported dysfunctional posttraumatic cognitions.ConclusionsMein Weg is effective for young refugees according to self‐reports and can be viewed as a valuable component in a stepped care approach for this vulnerable population. The findings need to be replicated with independent clinical assessments.
Primary visual cortex in neandertals as revealed from the occipital remains from the El Sidrón site, with emphasis on the newSD‐2300 specimen
Authors: García‐Tabernero Antonio , Peña‐Melián Angel , Rosas Antonio 
Published: April 2018

AbstractThe comparative analysis of the endocranial surface of the El Sidrón new occipital fragmentSD‐2300 shows meaningful differences in the configuration of the occipital pole region between neandertals and anatomically modern humans (AMH). The particular asymmetries found in neandertals in the venous sinus drainage and the petalial patterns are recognizable in this new specimen as well. In addition, the supra‐ and infracalcarine fossae of the occipital pole region appear to deviate obliquely from the mid‐line when compared withsapiens. Due to the excellent preservation conditions ofSD‐2300, the main sulci and gyri of the occipital pole area have been identified, this degree of detail being uncommon in a fossil specimen; in general, the gyrification pattern is similar toAMH, but with some notable differences. Particularly interesting is the description of the lunate and the calcarine sulci. The lunate sulcus is located close to the occipital pole, in a similar posterior position to in otherHomospecies. Regarding the calcarine sulcus, there are significant differences in the primary visual cortex, with the V1 area, or Brodmann area 17, being larger inHomo neanderthalensisthan inHomo sapiens. This may lead to greater visual acuity in neandertals than insapiens.
Some Leaders Come from Nowhere: Their Success Is Uneven
Authors: Eagly Alice H. 
Published: April 2018

AbstractSometimes leaders seem to come from nowhere—that is, from a social group or situation has seldom produced leaders. Their emergence generally requires special conditions and unusual competence. Once occupying such a role, unexpected leaders have to meet challenges that are more difficult than those faced by expected leaders. Angela Merkel, Chancellor of Germany, provides an example of a political leader who, against all odds, has achieved high office and extraordinary success. Both role congruity theory and social identity theory explicate the processes that enable such leaders to emerge and sometimes be successful despite their origins in a marginal status or unusual social location. When unexpected leaders are successful, they serve as symbolic vanguards of social change and sometimes produce wider social change in groups, organizations, or nations.
Observation about phosphorus and protein supply in cats and dogs prior to the diagnosis of chronic kidney disease
Authors: Böswald L. F. , Kienzle E. , Dobenecker B. 
Published: April 2018

SummaryThere is evidence that nutritional phosphorus (P) excess may be a risk factor for chronic kidney disease (CKD) in humans and pets (Advances in Nutrition: An International Review Journal (2014), 5, 104;The American Journal of Clinical Nutrition, (2013), 98, 6;Journal of Feline Medicine and Surgery, (2017); The source of phosphorus influences serum PTH, apparent digestibility and blood levels of calcium and phosphorus in dogs fed high phosphorus diets with balanced Ca/P ratio.Proc. Waltham International Nutritional Sciences Symposium, USA;Clinical aspects of natural and added phosphorus in foods, 2017,Springer Science+Business, Media). A retrospective study was conducted in order to gather data about P and protein intake in the feeding history of dogs and cats prior to the diagnosis ofCKD. Cases of 75 dogs and 16 cats withCKDwith comprehensive nutritional history presented to the nutrition consultation service of the Chair of Animal Nutrition and Dietetics, Ludwig‐Maximilians‐University Munich, between October 2009 and March 2016, were evaluated. Cases of age‐matched dogs (n = 57) and cats (n = 18) without diagnosed or suspectedCKDserved as controls. The most frequent type of diet used in the four groups (catsCKD, cats control, dogsCKDand dogs control) was home‐made. In all groups, P and protein supply was in excess (>150%) of the recommended daily allowances (RDA;Nutrient requirements of dogs and cats(2006), National Research Council, National Academy Press). Between the dog groups, no differences regarding P and protein intake existed. The P and protein intake relative to theRDAwas altogether higher in cats than in dogs. Cats withCKDshowed significantly higher P and protein intakes prior to diagnosis than the control cats (170 ± 36 vs. 123 ± 34 mg P/kgBW0.67;p < .05). These observations call for further investigations into the long‐term effects of P excess.
Sleep disorders in spinocerebellar ataxia type 10
Authors: London Ester , Camargo Carlos H. F. , Zanatta Alessandra , Crippa Ana C. , Raskin Salmo , Munhoz Renato P. , Ashizawa Tetsuo , Teive Hélio A. G. 
Published: April 2018

SummaryAs sleep disturbances have been reported in spinocerebellar ataxias (SCAs), including types SCA1, SCA2, SCA3, SCA6 and SCA13, identification and management of these disturbances can help minimise their impact on SCA patients' overall body functions and quality of life. To our knowledge, there are no studies that investigate sleep disturbances in SCA10. Therefore, the aim of this study was to assess sleep disturbances in patients with SCA10. Twenty‐three SCA10 patients and 23 healthy controls were recruited. Patients were evaluated in terms of their demographic and clinical data, including disease severity (Scale for the Assessment and Rating of Ataxia, SARA) and excessive daytime sleepiness (Epworth Sleepiness Scale, ESS), and underwent polysomnography. SCA10 patients had longer rapid eye movement (REM) sleep (p = .04) and more REM arousals than controls (p< .0001). There was a correlation of REM sleep onset with the age of onset of symptoms (r = .459), and with disease duration (r = −.4305). There also was correlation between the respiratory disturbance index (RDI) and SARA (r = −.4013), and a strong indirect correlation between arousal index and age at onset of symptoms (r = −.5756). In conclusion, SCA10 patients had sleep abnormalities that included more REM arousals and higher RDI than controls. Our SCA10 patients had sleep disorders related to shorter disease duration and lower severity of ataxia, in a pattern similar to that of other neurodegenerative diseases.
Systemic exertion intolerance disease/chronic fatigue syndrome is common in sleep centre patients with hypersomnolence: A retrospective pilot study
Authors: Maness Caroline , Saini Prabhjyot , Bliwise Donald L. , Olvera Victoria , Rye David B. , Trotti Lynn M. 
Published: April 2018

SummarySymptoms of the central disorders of hypersomnolence extend beyond excessive daytime sleepiness to include non‐restorative sleep, fatigue and cognitive dysfunction. They share much in common with myalgic encephalomyelitis/chronic fatigue syndrome, recently renamed systemic exertion intolerance disease, whose additional features include post‐exertional malaise and orthostatic intolerance. We sought to determine the frequency and correlates of systemic exertion intolerance disease in a hypersomnolent population. One‐hundred and eighty‐seven hypersomnolent patients completed questionnaires regarding sleepiness and fatigue; questionnaires and clinical records were used to assess for systemic exertion intolerance disease. Sleep studies, hypocretin and cataplexy were additionally used to assign diagnoses of hypersomnolence disorders or sleep apnea. Included diagnoses were idiopathic hypersomnia (n = 63), narcolepsy type 2 (n = 25), persistent sleepiness after obstructive sleep apnea treatment (n = 25), short habitual sleep duration (n = 41), and sleepiness with normal sleep study (n = 33). Twenty‐one percent met systemic exertion intolerance disease criteria, and the frequency of systemic exertion intolerance disease was not different across sleep diagnoses (p = .37). Patients with systemic exertion intolerance disease were no different from those without this diagnosis by gender, age, Epworth Sleepiness Scale, depressive symptoms, or sleep study parameters. The whole cohort reported substantial fatigue on questionnaires, but the systemic exertion intolerance disease group exhibited more profound fatigue and was less likely to respond to traditional wake‐promoting agents (88.6% versus 67.7%, p = .01). Systemic exertion intolerance disease appears to be a common co‐morbidity in patients with hypersomnolence, which is not specific to hypersomnolence subtype but may portend a poorer prognosis for treatment response.
The contribution of scenic views of, and proximity to, lakes and reservoirs to property values
Authors: Nicholls Sarah , Crompton John L. 
Published: April 2018

AbstractWater is arguably the world's most critical resource, although its aesthetic and recreational functions typically receive less attention than its consumptive uses. Views of, and access to, attractive water resources are capitalized into property prices in the form of sales price and rental premiums, measured since the 1970s with the hedonic pricing technique. This study synthesizes the evidence to date with respect to the value of lakes and reservoirs as aesthetic and recreational resources to nearby residents. Findings are reported relating to the effects of scenic views of, and proximity, to reservoirs and large artificial lakes, the North American Great Lakes, and other smaller inland lakes. Of the 44 distinct reviewed studies that included tests of statistical significance, only two failed to produce any significant findings in the directions anticipated (i.e., a positive impact of water frontage or view and/or negative impact of increasing distance). Improvements in methodological approaches—from early studies employing anecdotal observation and visual comparison to more recent investigations employing advanced geographical information systems and rigorous spatially explicit regression techniques—are traced. The potential implications of climate variability and changes for property values are addressed, as is the growing movement towards the adoption of green infrastructure. The need to consider changes to aesthetic and recreational values, in addition to outcomes for more traditional consumptive uses during cost–benefit analyses associated with proposed (re)developments, is emphasized.
Evolutionary and ecological traps for brown bears Ursus arctos in human‐modified landscapes
Authors: Penteriani Vincenzo , Delgado María Del Mar , Krofel Miha , Jerina Klemen , Ordiz Andrés , Dalerum Fredrik , Zarzo‐Arias Alejandra , Bombieri Giulia 
Published: April 2018

Abstract

Evolutionary traps, and their derivative, ecological traps, occur when animals make maladaptive decisions based on seemingly reliable environmental cues, and are important mechanistic explanations for declines in animal populations.

Despite the interest in large carnivore conservation in human‐modified landscapes, the emergence of traps and their potential effects on the conservation of large carnivore populations has frequently been overlooked.

The brown bear Ursus arctos typifies the challenges facing large carnivore conservation and recent research has reported that this species can show maladaptive behaviours in human‐modified landscapes. Here we review, describe and discuss scenarios recognised as evolutionary or ecological traps for brown bears, and propose possible trap scenarios and mechanisms that have the potential to affect the dynamics and viability of brown bear populations.

Six potential trap scenarios have been detected for brown bears in human‐modified landscapes: 1) food resources close to human settlements; 2) agricultural landscapes; 3) roads; 4) artificial feeding sites; 5) hunting by humans; and 6) other human activities. Because these traps are likely to be of contrasting relevance for different demographic segments of bear populations, we highlight the importance of evaluations of the relative demographic consequences of different trap types for wildlife management. We also suggest that traps may be behind the decreases in brown bear and other large carnivore populations in human‐modified landscapes.
R(NA)‐tistic expression: The art of matching unknown mRNA and proteins to environmental response in ecological genomics
Authors: Stanford Brenna C. M. , Rogers Sean M. 
Published: April 2018

A challenge of modern ecological genomics is reducing uncertainty surrounding the biological inferences from gene expression. For example, approximately 40% of proteins in eukaryotic model organisms do not contain characterized domains (Gollery et al., 2006). Even proteins of “known function” are typically only characterized in the sense that they have a domain function, but provide no information on their biological role within the cell (e.g., activation, pathways or targets). Yet, as molecular ecologists, a common objective is to elucidate how organisms respond to environmental variation through changes in gene expression, including homoeostatic, acclimatory, and adaptive responses to environmental stressors, a challenge increased by poor protein ecological annotation. Now, in this issue of Molecular Ecology, Orsini et al. (2017) use the quintessential Daphnia system to characterize the differences in stress response in three genotypic backgrounds to common biotic and abiotic stressors found in nature. Using an optimized weighted gene co‐expression network analysis, they link genes of unknown function to genes that they co‐activate with and enrich for gene ontology. Determining the functional networks of genes that behave in genotype‐ and treatment‐specific responses gives insight into possible pathways and respective ecological roles, helping pave the way for the next generation of transcriptomic studies in molecular ecology.
Interferon‐alpha induced psoriasis in a teenager
Authors: Mendieta Karen L. , Irfan Mahwish , Fernandez Faith Esteban 
Published: April 2018

AbstractExacerbation of preexisting and development of new‐onset psoriasis have been reported secondary to interferon treatment and, more recently, with newer biologic agents. We report a case of interferon‐induced psoriasis in an adolescent with hepatitis C, a rarely reported medication reaction in children. This case highlights the importance of reviewing a patient's medication list when evaluating cutaneous disorders.
Fatal hyperammonemia associated with disseminated Serratia marcescens infection in a pediatric liver transplant recipient
Authors: Mouat Stephen , Bishop Jonathan , Glamuzina Emma , Chin Simon , Best Emma J. , Evans Helen M. 
Published: April 2018

AbstractHyperammonemia is a rare and important complication post‐liver transplantation. We review a case of a 5‐month‐old boy with biliary atresia who received a split liver transplant following a variceal bleed. The transplant was complicated by recurrent portal vein thrombosis. Colonized with Serratia marcescens pretransplant, he developed disseminated infection associated with very high levels of ammonia that led to his death. It is important to be aware of serum ammonia levels in patients with portal vein thrombosis, particularly in the setting of gastrointestinal bleeding and sepsis.
Spinoza's Rethinking of Activity: From the Short Treatise to the Ethics
Authors: Sangiacomo Andrea , Nachtomy Ohad 
Published: April 2018

AbstractThis paper argues that God's immanent causation and Spinoza's account of activity as adequate causation (of finite modes) do not always go together in Spinoza's thought. We show that there is good reason to doubt that this is the case in Spinoza's early Short Treatise on God, Man and His Well‐being. In the Short Treatise, Spinoza defends an account of God's immanent causation without fully endorsing the account of activity as adequate causation that he will later introduce in the Ethics (E3def2). We turn to an examination of how God's immanent causation relates to the activity of finite things in the Ethics. We consider two ways to think about the link between God, seen as immanent cause, and the activity of finite things: namely, in terms of entailment and in terms of production. We argue that the productive model is most promising for understanding the way in which the activity of finite things and God's immanent causality are connected in Spinoza's (mature) philosophy
Algunas consideraciones sobre la experiencia estética: ¿ideología estética o posibilidad crítica?
Authors: Garnica Naím 
Published: April 2018

<p>El artículo intenta reconstruir de qué modo la experiencia estética se habría convertido en una categoría central de la estética contemporánea. A partir del aporte de distintos teóricos y filósofos del arte, pretendemos acercarnos a las potencialidades y límites de esta categoría, prestando atención tanto a los planteos que la defienden, como también a aquellos que la acusan de constituirse en una nueva forma ideológica. Al parecer, el concepto de obra de arte se ha vuelto obsoleto y la comprensión de los procesos del arte actual se ha canalizado mediante el concepto de experiencia estética.</p><p> </p>
Los ángeles y el poder celestial: el racionalismo de Maimónides versus el misticismo y la duplicidad del trono
Authors: Taub Emmanuel 
Published: April 2018

<p>La figura de los ángeles está presente en la tradición bíblica judía, así como en la literatura judía de los textos intertestamentarios y, aunque se suele especular con la falta de una “angeología judía”, la figura del ángel juega un papel preponderante en la administración del cielo y de la tierra. Partiendo de la caracterización de la figura de los ángeles para Maimónides, en este trabajo se busca entender el porqué del intento de racionalización de la angeología por parte del gran filósofo y sus implicancias teológico-políticas. En especial, en lo concerniente al rol de los ángeles en la admi- nistración del universo y en la relación con los hombres, así como también en su disputa con el poder celestial.</p><p> </p><p> </p>