bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the oncological and functional outcomes of brachytherapy and radical prostatectomy for localized prostate cancer
Authors: Wang Fei , Ding Xue fei , Luan Yang , Xu Yao-zong , Guo Cheng-hao , Zhu Liang-yong 
Published: September 2019

Abstract
Objective:To compare the oncological and functional outcomes of brachytherapy(BT) and radical prostatectomy(RP) in patients with localized prostate cancer(PCa).Methods:We retrospectively analyzed data from 415 patients with localized PCa who were treated with RP (n= 280) or BT (n=135) at Northern Jiangsu People's Hospital between November 2012 and April 2019. Biochemical relapse-free survival(bRFS) and cancer-specific survival (CSS) were compared. Multivariate Cox regression analysis was used to evaluate bRFS. Health-related quality of life(HRQoL) was measured using the Expanded Prostate Cancer Index Composite(EPIC) questionnaire.Results:The BT group was older, had a higher initial PSA, and had a higher proportion of high-risk patients. The median follow-up time was 38.6 months. The 3-year bRFS was 77.3% in the RP group versus 84.0% in the BT group(P=0.246). For the RP group, the 3-year bRFS for patients presenting with low-, intermediate-, and high-risk disease was 90.3%, 79.6% and 71.3%, respectively, compared with 90.9%, 93.8% and 80.7% in the BT group(P=0.948,0.213,0.263, respectively). The 3-year CSS was 96.1% in the RP group versus 94.5% in the BT group(P=0.948). For the RP group, the 3-year CSS for patients presenting with low-, intermediate-, and high-risk disease was 100%, 100% and 92.8%, respectively, compared with 100%, 100% and 92.4%, for the BT group(P=0.620). Based on multivariate Cox regression analysis, clinical T stage ≥ T2b was the main independent prognostic factor for bRFS. Regarding the quality of life, compared with the baseline, both treatments produced a significant decrease in different aspects of HRQoL at 3, 6 and 12 months after treatment. Patients in the BT group had lower HRQoL with regard to urinary irritation/obstruction and bowel function or bother, while patients in the RP group had lower HRQoL concerning urinary incontinence and sexual function or bother. There was no significant difference in HRQOL aspects between the two groups after follow-up for 2 years compared with the baseline.Conclusion:BT provides equivalent oncological control outcomes for patients with localized PCa compared with RP. Clinical T stage ≥ T2b was the independent prognostic factor for bRFS. BT had better HRQoL compared with RP, except for urinary irritation/obstruction and bowel function or bother, but returned to baseline after 2 years.
Clinical effect analysis and radiographic outcomes of Isobar TTL system for two-segmental lumbar degenerative disease: a retrospective study
Authors: Ji Zhisheng , Ji Zhi-Sheng , Yang Hua , Yang Yu-Hao , Li Shao-Jin , Luo Jian-Xian , Zhang Guo-Wei , Lin Hong-Sheng 
Published: September 2019

Abstract
Background: Non-fusion fixation is an effective way to treat lumbar degeneration. The present study evaluated the clinical effect analysis and radiographic outcomes of Isobar TTL system for two-segmental lumbar degenerative disease.
Method: Forty-one patients with two-segmental lumbar degenerative disease who underwent surgical treatment by Isobar TTL dynamic stabilization system (n=20) and rigid system (n=21) from January 2013 to June 2017. The mean follow-up period was 23.6 (range 15–37) months. Clinical outcomes were evaluated by oswestry dysfunction index (ODI), visual analogue score (VAS) and modified Macnab. Radiographic evaluations included the height of intervertebral space and range of motion (ROM) of the operative segments and proximal adjacent segment. The intervertebral disc signal change was classified by the modified Pfirrmann grade and University of California at Los Angeles (UCLA) system.
Results: The clinical outcomes including the ODI and VAS were significantly improved in two groups after operation, but the difference between two groups was not significant. In addition, the clinical efficacy of modified Macnab in two groups was similar too. Radiologic outcomes include height of intervertebral space, lumbar mobility and intervertebral disc signal. The height of intervertebral space of upper adjacent segments of L2/3 in the rigid group were significantly lower than those in the Isobar TTL group at the last follow-up. Furthermore, the number of fixed segment ROM of L3/4 in Isobar TTL group was significantly lower than pre-operation, suggesting that fixed segment ROMs in Isobar TTL group were limited. And, the ROM of upper adjacent segments of L2/3 in the last follow-up of rigid group increased significantly, while the ROM of L2/3 in Isobar TTL group haven’t changed after operation. At last, the incidence of adjacent segment degeneration was significantly greater in the rigid group than the Isobar TTL group according to modified Pfirrmann grading system and the UCLA system.
Conclusion: Isobar TTL system could get a good clinical effect for treatment of two-segmental lumbar degenerative disease. Compared with rigid fixation, Isobar TTL system can get better radiographic outcomes and maintain the mobility of the stabilized segments with less influence on the proximal adjacent segment.
Intra-aortic Balloon Pump Therapy for Anterior ST-elevation Myocardial Infarction with Cardiogenic Shock: An Observational Cohort Study
Authors: Zhou Kuo , Lyu Shuzheng , Dai Jing , Tian Jinfan , Cui Kongyong , Yan Yunfeng , Chen Lingxiao , Qin Zheng , Zhou Yutian 
Published: September 2019

Abstract
Background As a mechanical circulatory assistance, intra-aortic balloon pump (IABP) has been widely used for cardiogenic shock (CS), although recent clinical trials questioned its impact on acute myocardial infarction patients, nothing is hitherto known on the contribution of IABP to CS patients after anterior wall infarction. The aim of this study was to investigate the efficacy and safety of IABP therapy in patients presenting with anterior ST-elevation myocardial infarction (STEMI) complicated by CS.Methods We conducted a retrospective study of 215 consecutive patients presenting with CS after STEMI in the anterior wall between January 2006 and August 2017, including 125 patients in the IABP group and 90 patients in the control group.Results At 30 days, 60 (48.0%) patients in the IABP group and 58 (64.4%) patients in the control group had died (P=0.017). The Kaplan-Meier survival curves showed the cumulative survival rate in the IABP group was consistently higher than control group (P=0.009 by Log-Rank test). Nevertheless, IABP increased the occurrence of thrombocytopenia (21.6% vs. 2.2%, P<0.001) and lower limb complications (20.0% vs. 2.2%, P<0.001) at the same time. Subgroup analyses by Cox regression showed a better trend of prognoses in patients aged less than 60 years old (HR=0.49, 95% CI=0.26-0.91, P=0.025), male (HR=0.53, 95% CI=0.34-0.83, P=0.005), no history of hypertension (HR=0.47, 95% CI=0.26-0.87, P=0.017) and systolic blood pressure less than 80 mm Hg (HR=0.40, 95% CI=0.22-0.73, P=0.009). At 12-month follow-up, all-cause mortality in the IABP group was obviously lower than the control group (52.5% vs. 74.1%, P=0.002), there were no significant differences in other adverse cardiovascular events (P=1.000).Conclusions The combination of IABP use is associated with reduced 30-day and 12-month mortality in patients with anterior STEMI complicated by CS, though thrombocytopenia and lower limb complications are frequently observed.
Combined therapy of somatostatin analogues with pegvisomant for the treatment of acromegaly: a meta-analysis of prospective studies
Authors: Ma Lingyun , Luo Daohuang , Yang Ting , Wu Songtao , Li Min , Chen Chaoyang , Zhou Shuang , Ma Lingyue , Wu Ye , Zhou Ying , Cui Yimin 
Published: September 2019

Abstract
Background: Acromegaly is a rare, chronic and severe disease . Drug therapy including somatostatin analogues , dopamine receptor agonists and growth hormone receptor antagonists are commonly used to treat patients who do not responde to surgery. T he use of combination therapy with PEG and SAs has become more common over the last decade . We performed this study t o accurately evaluate the effect of combination therapy of somatostatin analogues (SAs) with pegvisomant (PEG) on acromegalic patients. Methods: PubMed, EMBASE, The Cochrane Library, and ClinicalTrials.gov were searched for relevant studies. Prospective clinical trials treating acromegaly with the co-administration of SAs and PEG were included. We performed a meta-analysis by using Stata 12.1 . Sensitivity analysis was conducted to explore heterogeneity. Results: Eight studies were included in this meta-analysis. The overall rate of serum insulin-like growth factor 1 (IGF-1) normalization was 75% (95% CI: 50%–93%; I 2 =93.60%). The combination therapy did not significantly change patients’ fasting plasma glucose (ES: 0.011 mmol*L -1 ; 95% CI: − 0.374 to 0.397 mmol*L -1 ; P=0.954) or glycosylated haemoglobin (ES: -0.106%; 95% CI: − 0.302% to 0.089%; P=0.285) while decreasing the fasting plasma insulin (ES: −21.487 pmol*L-1; 95% CI: −35.713 to -7.260 pmol*L-1; P=0.003). Elevation of liver enzyme levels was found in 14% (95% CI: 10% to 19%) of the patients. Conclusions: Combined therapy of SAs and PEG effectively normalized IGF-1 levels in most of the patients whose IGF-1 level was greater than the upper limit of normal after high dose SAs monotherapy. The combination therapy significantly decreased patients’ fasting plasma insulin. However, improved fasting plasma glucose or glycosylated haemoglobin was not found during the combination therapy. Moreover, elevated liver enzyme levels were observed in a small number of patients, which suggests a need for liver function monitoring. Trial registration We have our protocol registered in PROSPERO. (Registration number: CRD42019115549)
Correlation between Height And Percent Body Fat with Musculoskeletal Fitness at Adolesence
Authors: Rahmayanti Kamilia , Sudiarti Trini 
Published: September 2019

<em>This study aims to determine the relationship between energy and nutrients intake, body weight, height, BMI-for-Age, percent body fat, physical activity, and socioeconomic status with musculoskeletal fitness. This study used a cross-sectional design. A total of 151 students from </em>5<em> Bekasi High School class X and XI were included in this study. Food intake was measured using 2x24 hours food recall, physical activity using Global Physical Activity Questionnaire (GPAQ), </em><em>anthropometri by direct measurement, and socioeconomic using Family Affluence Scale (FAS) questionnaire. Regression analysis for bivariate and Anova for analysis of socioeconomic status. The results of this study showed that there were a significant relationship between energy (p=0,001) and nutrients intake (carbohydrate p=0,037; protein (p=0,001; fat (p=0,001), body weight (p=0,002), height (p=0,001), percent body fat (p=0,001), and physical activity (p=0,001) with musculoskeletal fitness before controlled by sex. After stratification analysis by sex, there was a significant relationship between height and percent body fat with musculoskeletal fitness(p&lt;0,005), but only found in male students.</em>
How Contextual Constraints Shape Midcareer High School Teachers' Stress Management and Use of Digital Support Tools: Qualitative Study
Authors: Manning Julia B , Blandford Ann , Edbrooke-Childs Julian , Marshall Paul 
Published: September 2019

Background
Persistent psychosocial stress is endemic in the modern workplace, including among midcareer high school (secondary comprehensive) teachers in England. Understanding contextual influences on teachers' self-management of stress along with their use of digital health technologies could provide important insights into creating more usable and accessible stress support interventions.

Objective
The aim of this study was to investigate the constraints on stress management and prevention among teachers in the school environment and how this shapes the use of digitally enabled stress management tools.

Methods
Semistructured interviews were conducted with 14 teachers from southern England. The interviews were analyzed using thematic analysis.

Results
Teachers were unanimous in their recognition of workplace stress, describing physical (such as isolation and scheduling) and cultural (such as stigma and individualism) aspects in the workplace context, which influence their ability to manage stress. A total of 12 participants engaged with technology to self-manage their physical or psychological well-being, with more than half of the participants using consumer wearables, but Web-based or smartphone apps were rarely accessed in school. However, digital well-being interventions recommended by school leaders could potentially be trusted and adopted.

Conclusions
The findings from this study bring together both the important cultural and physical contextual constraints on the ability of midcareer high school teachers to manage workplace stress. This study highlights correlates of stress and offers initial insight into how digital health interventions are currently being used to help with stress, both within and outside high schools. The findings add another step toward designing tailored digital stress support for teachers.
The effectiveness of ozone therapy as a non-drug method for treatment of initial caries of permanent teeth in children
Authors: Oliynyk R.P. , Rozhko M.M. , Habchuk V.S. 
Published: September 2019

Background. It is proved that the use of ozone will contribute to the growth of caries dental resistance, but the question about the adequacy of this method for the complete restoration of the already partly demineralized enamel structure remains controversial. Therefore, the purpose of our study was to determine the effectiveness of the isolated use of ozone for the treatment of initial caries of permanent teeth in children of different age groups (6, 12 and 15 years old). Materials and me­thods. We have performed treatment of initial caries with Ozone DTA/Ozonymed in 60 patients aged 6 to 15 years. CRT test was used to assess the structural resistance of enamel to the action of the acid factor. The enamel resistance to caries was determined using a modified enamel resistance of teeth test. The statistical processing of the study results was carried out in the Microsoft Excel 2017 software using arithmetic mean, arithmetic mean deviations, Pearson, Spearman and point-biserial correlation coefficients. Results. Results of the initial topographical distribution of caries lesions analysis showed a statistically higher (p ≤ 0.05) frequency of chewing teeth fissure defeat (36.67 %) compared with pathology of another localization. The sites of initial caries in 58.33 % of the examined persons were found on the upper jaw, in 46.67 % — on the lower. There was a decrease in the number of patients with a maximum and high risk of caries progression within a month of treatment — by 3.33 and 5.0 %, respectively. And three months later, the reduction in the number of patients with high risk of caries progression was documented (by 49.98 %). The finding indicate a positive ozone effect in terms of enamel resistance index increasing. However, none of the patients ma­naged to achieve a complete reduction of carious spot, although a significant percentage of examined children noted a decrease in its size to those that statistically differed from the initial ones (p < 0.05). Conclusions. Feasibility of non-drug methods of initial caries treatment implementation was justified, however, the effectiveness of isolated ozone use is not enough.
Залежність літогенності жовчі від показників вуглеводного та ліпідного обмінів у хворих на цукровий діабет типу 2 із хронічним некалькульозним холециститом
Authors: Marchuk Yu.F. , Pashkovska N.V. , Andriychuk D.R. , Fediv O.I. 
Published: September 2019

Мета дослідження: виявити особливості зміни гомеостазу жовчі та основні каменеутворюючі субстрати при хронічному некалькульозному холециститі та цукровому діабеті (ЦД) типу 2. Матеріали та методи. Клінічне обстеження проведено в 60 осіб, хворих на ЦД типу 2 та хронічний некалькульозний холецистит, у 60 осіб, хворих на ізольований хронічний некалькульозний холецистит, та 20 практично здорових осіб. Проведено ретельне обстеження з використанням загальноприйнятих клінічних, лабораторних, біохімічних, інструментальних досліджень. Усім пацієнтам здійснено багатомоментне дуоденальне зондування. Визначено ліпідні спектри крові та міхурової порції жовчі. Результати. У хворих на хронічний некалькульозний холецистит, що перебігає на тлі ЦД типу 2, спостерігалися підвищення рівнів загальних ліпідів (у 1,61 раза в крові), холестеролу (у 2,04 раза у крові та 1,62 раза в жовчі), жовчних кислот (у 4,4 раза в крові) та зниження їх у жовчі (у 1,34 раза), тріацилгліцеролів (у 3,09 раза в крові), ліпопротеїнів низької щільності (у 1,2 раза в крові) і зниження вмісту ліпопротеїнів високої щільності (у 1,98 раза в крові) та фосфоліпідів (у 1,38 раза в крові та в 1,48 раза в жовчі), а також зниження двокомпонентних співвідношень «фосфоліпіди/холестерол» (у 1,8 раза) та «жовчні кислоти/холестерол» (у 1,9 раза), підвищення трикомпонентного індексу Ісаксона (у 1,85 раза), що свідчить про істотний дисбаланс ліпідного обміну як предиктора формування жовчних конкрементів у даної категорії хворих (р < 0,05). Висновки. У хворих на хронічний некалькульозний холецистит на тлі ЦД типу 2 спостерігаються вірогідно підвищені рівні загальних ліпідів, холестеролу, жовчних кислот, тріацилгліцеролів, ліпопротеїнів низької щільності на тлі зниження ліпопротеїнів високої щільності та фосфоліпідів у сироватці крові та жовчі. Встановлені кореляційні зв’язки між ліпідними спектрами сироватки крові та жовчі дають більш повну та детальну інформацію про порушення гомеостазу жовчі в різних групах пацієнтів. Основним каменеутворюючим субстратом в осіб першої групи виступав холестерол, а в осіб другої групи — знижений рівень ліпопротеїнів високої щільності.
Ефективність застосування Нейромідину® в комплексному лікуванні діабетичної дистальної симетричної полінейропатії
Authors: Pashkovska N.V. , Pashkovsky V.M. , Zoriy I.А. 
Published: September 2019

Мета: встановлення ефективності й безпеки застосування препарату іпідакрину (Нейромідин®) у хворих на цукровий діабет, ускладнений дистальною симетричною полінейропатією (ДСПН). Матеріали та методи. Обстежено 110 хворих на ДСПН. Відібрані пацієнти були поділені на дві групи: І група (24 хворі) — особи, які отримували базисну терапію; ІІ група (50 хворих) — пацієнти, які на тлі базисного лікування отримували препарат Нейромідин® у вигляді внутрішньом’язових ін’єкцій по 5 мг двічі на добу протягом 10 днів, потім перорально по 20 мг тричі на добу впродовж 20 днів. Проводилося неврологічне обстеження за шкалами нейропатичного симптоматичного підрахунку, модифікованого нейропатичного дисфункціонального підрахунку, електронейроміографічне (ЕНМГ) тестування периферичних нервів нижніх кінцівок. З метою встановлення особливостей когнітивних функцій використовували тест Mini­Mental State Examination. Також оцінювали показники тривожності й депресії в динаміці лікування. Результати. У групі осіб, які на тлі базисної терапії отримували Нейромідин®, відзначалося вірогідне покращення показників суб’єктивної й об’єктивної симптоматики. Прояви аксонопатії й мієлінопатії за результатами ЕНМГ­тестування периферичних нервів вірогідно зменшувались у групі пацієнтів, які приймали на тлі базисної терапії Нейромідин®. Також на тлі прийому Нейромідину® встановлено статистично значуще покращання когнітивних функцій, зменшення проявів тривоги й депресії. Висновки. Застосування Нейромідину® на тлі базисної терапії у хворих на ДСПН покращує процеси регенерації й реіннервації периферичних нервів нижніх кінцівок і, покращуючи проведення збудження моторними волокнами за даними ЕНМГ­параметрів, позитивно впливає на клінічній перебіг захворювання, а також дозволяє покращити когнітивні функції, зменшити прояви тривоги й депресії.
Оценка информативности и специфичности диагностических критериев для проведения первичного скрининга на акромегалию
Authors: Khyzhnyak O.O. , Mykytyuk M.R. , Nikolaiev R.S. , Barabash N.Ye. , Manska K.H. 
Published: September 2019

Актуальность. Наиболее эффективным методом ранней диагностики какого­либо заболевания, а особенно такого редкого, как акромегалия, считается популяционный скрининг в группах повышенного риска, внедрение которого в Украине требует разработки методологических подходов и экономического обоснования. Цель: на основании сравнительного анализа определить информативность и специфичность вопросов, которые будут включены в анкету первичного скрининга на акромегалию. Материалы и методы. Анкетирование проводилось в двух группах: группа 1 — больные, у которых диагноз акромегалии был верифицирован в Нейроэндокринологическом центре ГУ «Институт проблем эндокринной патологии им. В.Я. Данилевського НАМН Украины» (n = 123); группа 2 (n = 550) — лица из группы риска, которые пришли на амбулаторный визит к врачу общей практики — семейной медицины, терапевту, кардиологу, эндокринологу по разным причинам и при наличии соматической и/или эндокринной патологии. Анализ полученных данных проведен методом вариационной статистики с помощью программного комплекса SPSS 19.0 Statistical Software (IBM Corp., Armonk, NY, USA). Результаты. Первый блок вопросов разработанной анкеты направлен на определение фенотипических признаков, то есть оценку пациентом изменений его внешности. Второй блок вопросов анкеты направлен на выявление у больного жалоб, которые могут быть признаком патологического процесса в центральной нервной системе и гипофизе. На основании проведенного сравнительного анализа в окончательном варианте была предложена анкета из 11 вопросов, которые отображают наиболее достоверные признаки и клинические проявления перманентной гиперсоматотропинемии. Анкета предназначена для опроса лиц из групп риска с целью проведения оппортунистического скрининга на акромегалию. Выводы. Предложенная методика выявления значимости клинических признаков акромегалии позволяет с высокой вероятностью определить окончательные вопросы для анкеты, предназначенной для скрининга на акромегалию.