bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Lymphocytic Leukemia in a Bearded Dragon (Pogona vitticeps) and a Review of Literature
Authors: Gavazza Alessandra , Galosi Livio , Croce Veronica , Croce Amerio , Genovese Carla , Romano Paolo , Cerquetella Matteo , Rossi Giacomo 
Published: September 2019

Abstract
The present paper reports the case of a 3 years old, female Bearded Dragon (Pogona vitticeps) presenting lethargy, anorexia, weight loss, and anemia and marked leukocytosis at CBC. The majority of leukocytes were lymphocytic/lymphoblastic cells (97%). Immunocytochemical staining of blood smears marked for CD3 (neg) and CD79a (pos) suggested immunophenotype B. The patient died after one month from diagnosis. Histology evidenced lymphoid infiltration in the heart, spleen, liver, kidneys and gut. In addition, in the bone marrow a massive infiltration of lymphoid cells confirmed the diagnosis of leukemia. Immunohistochemistry confirmed the CD79a positivity of a large part of infiltrating lymphoid cells indicating a B cells immunophenotype of the neoplastic population. The presence of lymphocytosis and multiorgan infiltration supported the diagnosis of lymphocytic leukemia. Finally, a revision of the literature has also been made.
The effects of extracurricular physical education classes on gross motor development in primary school children – pilot study
Authors: Skowroński Waldemar , Skowrońska Marianna , Rutkowska Izabela , Bednarczuk Grzegorz , Kaźmierska-Kowalewska Kalina Maria , Marszałek Jolanta 
Published: September 2019

Summary

Study aim: The aim of the study was to investigate the changes in gross motor skills in children participating and not participating in a project of extracurricular physical education classes in primary schools called “From fun to sport”.

Material and methods: Thirty-one children in the first grade of primary school participated in the study (16 boys and 15 girls). A pedagogical quasi-experiment was applied. Children from the experimental group participated in an additional 45-minute lesson. To assess gross motor skills the TGMD-2 (Test of Gross Motor Development-2) was used.

Results: Statistically significant differences were observed in the level of gross motor skills between children attending extracurricular physical education classes and those who did not participate in such activities (GMDQ: Δ boys = 11.86, p = 0.032; Δ girls = 13.1, p = 0.036).

Conclusion: The experiment revealed large effects of additional activities of the project on increase of children’s motor skills level. Additional time should be included in physical education for the development of gross motor skills in physical education classes at the initial stage of school education.
Frustrating Absences
Authors: Abath André J. 
Published: September 2019

Abstract
Experiences of absence are common in everyday life, but have received little philosophical attention until recently, when two positions regarding the nature of such experiences surfaced in the literature. According to the Perceptual View, experiences of absence are perceptual in nature. This is denied by the Surprise-Based View, according to which experiences of absence belong together with cases of surprise. In this paper, I show that there is a kind of experience of absence—which I call frustrating absences—that has been overlooked by the Perceptual View and by the Surprise Based-View and that cannot be adequately explained by them. I offer an alternative account to deal with frustrating absences, one according to which experiencing frustrating absences is a matter of subjects having desires for something to be present frustrated by the world. Finally, I argue that there may well be different kinds of experiences of absence.
Gender and Absolute ‘I’ of a Person: Scope of Contraposition and New Contexts of Identity
Authors: Zharkimbayeva D. , Imanzhussip R. , Mukatayeva A. , Zhumaxanova M. , Bolyssova K. 
Published: September 2019

Abstract
The aim of the study is to investigate gender and absolute ‘I’ of a person as scope of contraposition and new contexts of identity. The methodological basis of the study of the philosophy of gender is the idea of the Absolute ‘I’ of a person, scope of contraposition of gender and sex, new contexts of gender identification. Person is inseparable from his essence, which determines his gender. As a result, identity is an open system, therefore the process of changing the identity of both men and women is an interdependent change of mindsets complementing and enriching each other and the world around. In conclusion, the male, which is obviously not changeable enough, can be ultimately completed to the female principle. People are attracted to men who prone to dialogue and mercy. But the feminine principle, which constitutes all the beauty in a person, is instant, and cannot have rigidity, totalitarian firm determination, in a word, those qualities that should have a long-term perspective.
Scientific and Pedagogical Bases of Civic and Patriotic Upbringing of Young Students
Authors: Alieva Sariat A. , Zakaryaeva Siadat Z. , Omarov Omarkhan N. , Radjabova Raisa V. , Kimpaeva Elmira A. , Gadjieva Patimat D. 
Published: September 2019

Abstract
The experience accumulated by pedagogical theory and practice of patriotic and civic upbringing of children and youth is currently undergoing a profound positive conceptualization and evaluation. The relevance of the problem under study is associated with the circumstance that under certain historical conditions there takes place purification, updating and manifestation of Russian values in the interests of the entire Homeland, both “smaller” and “greater” Motherland. The objective of this research is to find out scientific and pedagogical bases for the essence and content of civic and patriotic upbringing of young students at the contemporary stage. The leading principle of studying this problem is the principle of particular historical approach which implies matching the content, forms and methods of patriotic and civic upbringing in a certain historical situation. In this paper, the authors discuss the problems of patriotism and civic spirit in various historical, social and political, and economic conditions depending on their views influenced by the knowledge acquired and the personal civic stance developed under the effect of various factors, as well as attitude to their Homeland.
Sociology as Scientific Knowledge
Authors: Serpa Sandro , Ferreira Carlos Miguel 
Published: September 2019

Abstract
Sociology is a science with specificities and which can potentially offer a more rigorous knowledge about reality. The goal of this position paper is, by means of a thorough literature review, to contribute to demonstrating the urgency of using a sociological stance in a more complete understanding of the social, as well as of Sociology itself as a science. It is concluded that Sociology, a multi-paradigmatic science, seeks to articulate macro-social dynamics with local processes, allowing to connect the subjective significances with the practices, and which focus on the articulations between systems and actors, between structures and practices, between the reality of the social conditions of existence, and the social construction of reality. As an implication, Sociology as a scientific representation and practice of the social, can be cumbersome by helping to dismantle commonly shared preconceived ideas about the instituted social order.
A Study on Evaluating the Pedagogical Knowledge of School Teachers
Authors: Franklin Thambi Jose S , Ishak Samuel Samikkanu Jabamoney , Annamalai Manonmani Devi , Kumar Muniisvaran 
Published: September 2019

Abstract
Education plays an important role in a society. Each and every country around the globe has its own education system to educate their own society. In this way, Malaysia has its own education system. Here, students undergo education in different stages such as, kindergarten (pre-school), primary school (elementary), secondary school (high), and college or university. Of these, kindergarten, primary and secondary educations are in schools. School education is basic for a child. Hence, teacher role is very essential in teaching and learning process. Sultan Idris Education University is No.1 Education University which produces a lot of teachers and are been posted as teachers in various parts of the country. Thus posted teachers teach in secondary schools in Malaysia. The main objective of this study is to evaluate the pedagogy knowledge of the secondary school teachers using testing and evaluation theory. The study is limited to the Perak state teachers of Malaysia. The researcher has used the descriptive research method for this study. Questionnaire is prepared according to the essential pedagogical knowledge for the teachers based on testing and evaluation theory. The data are collected through observing the classroom teaching of the teachers. The findings of the study are described in this article.
Molecular Detection and Phylogenetic Analysis of Anaplasma Spp. in Cattle in Al-Qadisiyah Province of Iraq
Authors: Ayyez Hayder N. , Khudhair Yahia I. , Kshash Qassim Haleem 
Published: September 2019

Abstract

Anaplasma spp. are widely spread rickettsial bacteria transmitted by ticks and placing high impacts on veterinary and public health. A limited number of studies have been carried out on Anaplasmosis in the central part of Iraq. This study was conducted to determine the presence of Anaplasma spp. in cattle in Al-Qadisiyah province, Iraq. A total of 400 blood specimens were collected from cattle suffering from heavy tick infestation. Cattle were blood-sampled from four hyper-endemic areas with ticks. Blood samples were screened using microscopic and polymerase chain reaction (PCR) methods. Diff-quick stained blood smears revealed Anaplasma-like inclusion bodies in 254 (63.5%) samples. According to the 16S rRNA-gene-based PCR analysis, Anaplasma spp. was detected in 124 of the 400 (31%) samples, divided as 96/254 (37.8%) among the microscopical positive samples and 28/146 (19.17%) among the microscopical negative samples. Phylogenetic analysis based on the partial 16S rRNA gene sequencing of ten-PCR positive samples were 99–97% identical to sequences deposited in the GenBank, revealing presence of A. phagocytophilum, A. marginale and unnamed Anaplasma spp. in 40%, 20%, and 40% samples, respectively. Relationships among Anaplasma spp. infections and cattle breed, age, and sex were analyzed. Calves less than one year old showed significantly higher rates (p<0.005) than those from other age groups, whereas sex and breed demonstrated no significant differences (p˃0.001). This study shows that a variety of Anaplasma spp., were endemic in central part of Iraq and is still a hidden problem in cattle in the hyperendemic areas of tick, which requires serious control strategies.
Social Exclusion and Inclusion in the Czech Republic and in South Africa: Comparison and Facts
Authors: Brožovičová Klára 
Published: September 2019

Abstract
The article’s aim is to compare the opposite processes of social exclusion and inclusion in South Africa and in the Czech Republic, in the past and at the present time. Even though these societies differ culturally and geographically, the comparison of some important factors, which are causing the exclusion of some people groups, might be interesting. In both cases we will closely follow the social, ethnic and racial groups, which are mostly excluded in the given environment. In South Africa it concerns Black and Coloured Africans, and in the Czech Republic the Roma ethnic minority group, the only ethnic group which is to a high extent excluded. In the history of these two countries we can find a similar historic aspect, both of them had experienced totalitarian regimes. Today, with the benefit of more twenty years, we can see the changes, which both these countries have undergone, and observe as well how these changes influenced the processes of inclusion and exclusion of the given social, racial and ethnic groups.
Dusp6 inhibits epithelial-mesenchymal transition in endometrial adenocarcinoma via ERK signaling pathway
Authors: Fan Ming-Jun , Liang Shu-Mei , He Peng-Juan , Zhao Xing-Bo , Li Ming-Jiang , Geng Feng 
Published: September 2019

Abstract

Background
Endometrial adenocarcinoma (EAC) is one of the most commonly diagnosed gynaecological malignancies among female population of the developed countries. DUSP6 is a negative regulator of ERK signaling, which is a molecular switch involved in MAPK signaling during the progress of malignancies. DUSP6 was previously found to inhibit tumorigenesis and EMT-associated properties in several cancers, however, its exact role in EAC remains unclear

Methods
The level of DUSP6, (E-cad) and (N-cad) in EAC cancerous tissues and respective adjacent non-cancerous tissues were examined by western-blot or immunohistochemistry. The cell growth, invasion and migration abilities were measured in Ishikawa 3H12 endometrial cancer cell lines with overexpressed or knock down DUSP6. Protein levels of EMT-associated markers E-cadherin, N-cadherin and Vimentin were also determined. The impacts of DUSP6 on ERK signaling was assessed by detection of ERK and p-ERK.

Results
Down-regulation of DUSP6 was observed in EAC compared with the normal controls. The overexpression of DUSP6 significantly attenuated tumor cell growth, invasion, migration abilities and inhibited EMT-associated markers, while knock down of DUSP6 showed opposite trends. Overexpression of DUSP6 also down-regulated p-ERK and the knock down of DUSP6 inversely up-regulated p-ERK level.

Conclusions
DUSP6 inhibited cell growth, invasion and migration abilities in Ishikawa 3H12 cells as well as attenuating EMT-associated properties. This tumor suppressive effect of DUSP6 in EAC is achieved by inhibiting ERK signaling pathway.
Heterotopic ossification: radiological and pathological review
Authors: Mujtaba Bilal , Taher Ahmed , Fiala Matthew J. , Nassar Sameh , Madewell John E. , Hanafy Abdelrahman K. , Aslam Rizwan 
Published: September 2019

Abstract

Background
Heterotopic Ossification (HO) is a common condition referring to ectopic bone formation in soft tissues. It has two major etiologies, acquired (more common) and genetic. The acquired form is closely related to tissue trauma. The exact pathogenesis of this disease remains unclear; however, there is ongoing research in prophylactic and therapeutic treatments that is promising.

Conclusions
Due to HO potential to cause disability, it is so important to differentiate it from other causes in order to establish the best possible management.
Health-related quality of life in Croatian general population and multiple myeloma patients assessed by the EORTC QLQ-C30 and EORTC QLQ-MY20 questionnaires
Authors: Ficko Sanja Ledinski , Pejsa Vlatko , Zadnik Vesna 
Published: September 2019

Abstract

Background
The impact of disease and treatment on the patient’s overall well-being and functioning is a topic of growing interest in clinical research and practice. The aim of this study is to obtain reference data on quality of life of Croatian general population. Further, we aim to assess the impact of the disease and its primary systemic treatment on their health related quality of life (HrQoL) in multiple myeloma (MM) patients.

Patients and methods
Participants for the first part of the study were randomly selected from adult Croatian population. In the clinical part of the study MM patients were included as prospectively diagnosed within two years in two major Croatian haematological centres. The EORTC QLQ-C30 in both trials and QLQ-MY20 in MM patients only were applied for HrQoL assessment.

Results
Gender, age and place of residence have great impact on quality of life scores in Croatian population. The MM patients at the time of diagnosis have lower QLQ-C30 scores for global quality of life, functional and symptom scale scores, as well as single items. The type of disease followed by the choice of therapy options are important HrQoL determinants.

Conclusions
The norm values available now for Croatian population will help to interpret HrQoL for clinicians and aid in planning cancer care interventions. This study identified treatment effect consistent with those from other observational studies and provided new data on HrQoL across two different treatment choices for MM patients.
Investigation effects of some anthraquinones on human paraoxonase 1 (hPON1)
Authors: GÖKÇE Başak 
Published: September 2019

The in vitro effects of the some dihydroxyanthraquinone derivates, anthrorufin, xanthopurpurin, chrysazin and chrysaphanol which are commonly used as anticancer antibiotics, on the activity of purified serum paraoxonase 1 (PON1) (EC 3.1.8.1.) were investigated. Paraoxonase 1 was purified from human blood serum 355,12 fold with 55 % yield with use of ammonium sulphate precipitation and Sepharose-4B-L-tyrozine-1-napthylamine HIC (hydrophobic interaction chromatography) coloumn in return. Sodium Dodecyl Sulphate -polyacrylamide gel electrophoresis (SDS-PAGE) analysis of purified enzyme showed a single band belong to human serum PON1, 43 kDa. The four anthraquinones inhibited PON activity strongly, with IC50 values for anthrorufin, xanthopurpurin, chrysazin and chrysaphanol of 73, 72.25, 75.19 and 105.53 M respectively. Ki constants were determined 34.64, 39.51, 39.73 and 63.59 M, respectively. All anthraquinones showed inhibition in competitive manner.
PERBANDINGAN IDEOLOGI PADA NOVEL ‘AZRA’ JAKARTA DENGAN IMAGOLOGIE SEJARAH G30S-PKI VERSI PERPUSTAKAAN NASIONAL
Authors: Hailiyati Nia 
Published: September 2019

Tulisan ini bertujuan untuk menganalisis perbandingan ideologi pada novel Azra’ Jakarta dengan sejarah G30 S/ PKI versi perpustakaan nasional, data penenlitian adalah novel azra’ Jakarta yang di tulis oleh Najib Kaelani dan sejarah G30 S/ PKI versi perpustakaan nasional, data dianalisis dengan metode deskriptif dengan pendekatan perbandingan, sedangkan teknik pengumpulan data melalui studi pustaka dengan cara menjaring data tertulis melalui novel azra’ Jakarta dan buku sejarah G30 S/PKI. Berdasarkan hasil analisis, ditemukan ideologi yang dibangun oleh Najib Kaelani dalam novel adalah dari segi keagamaan, yakni (anti tuhan bagi pemimpin, nilai-nilai keislaman, yakni sebagai penyeimbangan antara ketertindasan kaum muslimin terhadap politik, penindasan terhadap kaum muslim), adapun dari segi politik menculik para pembesar negara, ideologi yang terdapat dalam sejarah G30 S/PKI versi Nasional aspek ketuhanan, yakni perubahan terhadap pancasila, aspek agama yakni pancasila adalah semangat toleransi yang bersumber pada kekuasaan Allah, aspek siasat PKI yakni mempengaruhi petani miskin, peberontakan PKI, penyusupan PKI kedalam jajaran aparatur negara, keterkaitan antara novel Azra’ Jakarta karangan Najib Kaelani dengan sejarah G30 S /PKI versi perpustakaan nasional adalah kedua-duanya terdapat nilai keIslaman yang berdasar kemanusiaan dan keadilan sosial, adanya kesamaan peristiwa yang terjadi ditempat si pengarang dengan sejarah Indonesia, diasumsikan Najib mempelajari kesejarahan Indonesi, segi keagamaan, negara asal pengarang mayorita Islam, begitu juga Indonesia, adnya kedekatan politik dengan pemimpin terhadap dua negara (Mesir dan Indonesia)
ANALISIS VARIASI DAN TINGKAT AKURASI PERHITUNGAN PAJAK PENGHASILAN (PPH) PASAL 23 DI KOTA MATARAM
Authors: Isnawati Isnawati , Isnaini Zuhrotul , Lenap Indria Puspitasari 
Published: September 2019

Pajak penghasilan (PPh) pasal 23 adalah pajak yang dipotong atas penghasilan yang berasal dari modal, penyerahan jasa, atau hadiah dan penghargaan, selain yang telah dipotong PPh Pasal 21. Aturan mengenai PPh Pasal 23 ini seringkali mengalami perubahan. Dharma (2007:1) menyatakan bahwa seiiring dengan perkembangan usaha, Direktur Jenderal Pajak melakukan perubahan terhadap Keputusan Direktur Jenderal Pajak Nomor KEP-170/PJ/2002 tentang Jenis Jasa lain dan Perkiraan Penghasilan Neto sebagaimana dimaksud dalam Pasal 23 ayat (1) huruf c Undang-Undang Nomor 7 Tahun 1983 tentang Pajak Penghasilan sebagaimana telah diubah terkahir dengan Undang-Undang Nomor 17 Tahun 2000. Dengan telah dikeluarkannya 1 (satu) Keputusan Direktur Jenderal Pajak dan 2 (dua) Peraturan Direktur Jenderal Pajak tentang Jenis Jasa Lain dan Perkiraan Penghasilan Netto PPh.Pasal 23 yang mempunyai masa berlaku yang berbeda, disamping itu perbedaan paling menonjol dari ketiga peraturan tersebut adalah masalah perkiraan penghasilan netto dan pengaturan mengenai obyek penyerahan yang harus dipotong PPh. Pasal 23. Apabila fiskus maupun wajib pajak kurang cermat, maka dampaknya akan mempengaruhi hak dan kewajibannya dibindang perpajakan. Kekhawatiran yang dinyatakan oleh Dharma tersebut tentunya berlaku juga untuk wilayah Kota Mataram, mengingat Kota Mataram berada di wilayah propinsi Nusa Tenggara Barat (NTB) yang merupakan propinsi dengan peringkat ke 27 dari 34 propinsi di Indonesia. Berdasarkan latar belakang tersebut, maka perlu dilakukan penelitian untuk mengetahui bagaimana cara fiskus maupun wajib pajak menghitung PPh.Pasal 23 tersebut. Selain itu penelitian ini perlu dilakukan untuk mengetahui seberapa akurat perhitungan yang dilakukan untuk PPh Pasal 23 tersebut. Penelitian ini merupakan Penelitian Deskriptif dengan menggunakan studi pustaka, yaitu menganalisa data yang sudah tertuang pada Laporan PKL Mahasiswa Prodi DIII Perpajakan FEB Unram. Dan hasil penelitian ini menggambarkan bahwa variasi perhitungan PPh Pasal 23 yang terdappat di Kota Mataram menggunakan tarif terbaru yaitu 2% dan 15% dikalikan dengan penghasilan Bruto. Tidak ditemukan pada sampel bahwa masih ada perusahaan maupun instansi yang masih menggunakan tarif yang lama seperti yang dilaporkan pada salah satu Laporan PKL mahasiswa Prodi D-III Perpajakan FEB Unram. Adapun kesalahan tersebut murni bersumber dari mahasiswa yang masih kurang memahami mengenai perhitungan PPh Pasal 23 tersebut
Keterampilan Merancang Lembar Kerja Siswa (LKS) Berbasis Learning Cycle 5E di MA Khairuddin Gondanglegi
Authors: Sari Yuli Ifana , Kurniawati Dwi 
Published: September 2019

LKS merupakan bahan ajar yang digunakan dalam proses pembelajaran. Guru sebagai fasilitator dalam pembelajaran di kelas memiliki peran strategis dalam pengembangan bahan ajar atau LKS.Materi workshop disusun didasarkan atas analisis kebutuhan peserta yang dilaksanakan melalui pelatihan dan pendampingan dengan guru.Rangkaian kegiatanworkshop yaitu: Informasi dan tanya jawab pengembangan LKS berbasis learning cycle materi litosfer.Hasil yang diperoleh dari kegiatan pengabdian antara lain: 1) bahan ajar/LKS dirancang sesuai dengan kebutuhan dan minat peserta didikserta tuntutan kurikulum yang berlaku, 2) guru memiliki keterampilan dalam menggembangkan LKS, 3) guru memiliki komitmen untuk menggembangkan LKS sendiri sebagai alat dalam pembelajaran, dan 4) adanya kesempatan guru dalam meningkatkan profesionalitasnya melalui workshop pengembangan LKS. Kata Kunci: Keterampilan merancang LKS, Workshop