bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synchronous processing of temporal information across the hippocampus, striatum, and orbitofrontal cortex
Authors: Shimbo Akihiro , Sekine Yukiko , Kashiwagi Saori , Fujisawa Shigeyoshi 
Published: November 2024

ABSTRACTInformation processing for interval timing is supported by several brain regions, including the hippocampus, basal ganglia, and frontal cortical areas. However, little is known about the mechanism by which temporal information is processed cooperatively in the distributed brain network. Here, we investigated the neuronal processing of temporal information in the hippocampal CA1, dorsal striatum, and orbitofrontal cortex by simultaneously recording neuronal activity during a temporal bisection task. We found time cells representing elapsed time during the interval period across all three regions. Seeking a potential mechanism for the correlative representation of time, we found that theta oscillations were dominant in these areas and modulated the activity of these time cells. Moreover, the synchronization of the time cell pairs across the areas was also regulated by theta oscillations. Taken together, these results demonstrated the presence of synchronous activity of time cells across the three areas on a fine time scale, which was supported by theta oscillations. In addition, decoding analysis revealed that the activity of the time cells in these areas correlated with the rats’ decisions based on their internal time estimation, with the decoded time also showing correlations across the three regions. Thus, the cooperative activity of time-cell assemblies in the three regions reflected the recognition of elapsed time in the rats. In conclusion, these results demonstrate the pivotal role of neuronal synchronization of time cells in supporting temporal processing in the distributed brain network.
Identification of a sub-population of synovial mesenchymal stem cells with enhanced treatment efficacy in a rat model of Osteoarthritis
Authors: Al-Jezani Nedaa , Affan Asmaa , Leonard Catherine , Das Nabangshu , Almeida Luiz Gustavo , Young Daniel , Masson Anand O. , Dufour Antoine , Salo Paul , Railton Pam , Powell James N. , Krawetz Roman J. 
Published: November 2024

AbstractOsteoarthritis (OA) is a painful and debilitating disease which has no cure and there are no treatments which can predictably stop/reverse its progression. Treating this disease is particularly difficult since the articular cartilage lacks intrinsic repair capacity even though mesenchymal stem cells (MSCs) are present in the joint environment and have robust chondrogenic potential. We have previously shown that there is heterogeneity of MSC sub-types within the human synovium, yet it remains unclear if any of these MSC types can regenerate cartilage and/or impact OA disease progression. Therefore, we have undertaken this study focusing on clonally derived MSC populations derived from the synovium of normal and OA patients to characterize if any MSC populations can positively impact OA disease trajectory in a rat model of OA.MSCs were clonally isolated by indexed flow cytometry, expanded in culture and then characterized for differentiation capacity and by quantitative proteomics. MSC clones were then transplanted into a xenograft rat OA model and treatment effect was determined by histology and immunofluorescence outcomes. We identified heterogeneity in putative MSCs derived from within and between patient groups (normal vs. OA) and the ability of these cells to effect repair in a rat OA model. However, these different sub-types of MSCs could not be distinguished by traditional cell surface markers showing the need for a better understanding of these populations at the single cell level. Using an unbiased proteomics approach, CD47 was identified a novel marker of human MSCs. Using the same rat model of OA, CD47Hiexpressing cells were found to have robust treatment efficacy and directly contributed to the formation of new articular cartilage tissue. Characterizing MSCs is essential to understand which sub-types are appropriate for further clinical investigation. If OA patients still have functional MSCs in their synovium, then it is possible these cells can be exploited for cartilage regeneration / OA treatment strategies.
Absence of CDK12 in oocyte leads to female infertility
Authors: Jansova Denisa , Sedmikova Veronika , Berro Fatima J. , Aleskhina Daria , Dvoran Michal , Kubelka Michal , Rezacova Jitka , Rutarova Jana , Kohutek Jiri , Susor Andrej 
Published: November 2024

AbstractTranscriptional activity and gene expression are essential for the development of a mature, meiotically competent oocyte. We have found that the absence of cyclin-dependent kinase 12 (CDK12) in oocytes leads to complete female sterility, as there are no fully developed oocytes able to accomplish meiosis I in the ovaries. Mechanistically, CDK12 in growing oocytes controls POLII activity and maintenance of the physiological maternal transcriptome, which negatively affects protein synthesis that promotes further oocyte growth. In addition, disruption of oocyte development disrupts folliculogenesis, resulting in a premature failure phenotype without terminal folliculogenesis and ovulation. In summary, we have characterized a single master regulator of the oocyte transcriptional program and gene expression that is essential for oocyte growth and female fertility.Graphical Abstract
Value co-creation in live streaming through tourism scenes: a contextual marketing perspective
Authors: Yu Jun , Xie Chaowu , Huang Songshan 
Published: November 2024

PurposeThis study aims to identify a value co-creation framework for live streaming through tourism scenes (LStTS). It also clarifies the value attributes of LStTS and makes an empirical test.Design/methodology/approachThe study used a mixed-method approach. In Study 1, a total of 12,216 pieces of viewers’ comments and ten web news reports were coded and analyzed employing a grounded theory approach. In Study 2, data were collected from 587 Douyin e-commerce users. Exploratory factor analysis and partial least squares structural equation modeling were used to test the value co-creation framework of LStTS.FindingsIn Study 1, six value attributes in three categories were identified based on a content analysis of viewers’ comments. In Study 2, a three-order factorial model of value co-creation in LStTS was identified and tested.Research limitations/implicationsOur study is limited by the preponderance of female respondents in the sample and the unique nature of the research context.Practical implicationsMerchants and streamers should consider whether there is a fit between the merchandise and the tourism scene when selecting the tourism scene for live streaming marketing; they can select novel and beautiful natural tourism scenes to attract viewers. Detailed and comprehensive product information should be provided in the process of live streaming marketing and sharing with consumers.Originality/valueThe novelty of our study lies in the provision of a new value co-creation framework in LStTS, which offers a theoretical basis for analyzing the value of the tourism scene in live streaming marketing.
Monetary policy and corporate investment: evidence from India
Authors: Bagow Sajad , Altaf Nufazil 
Published: November 2024

Purpose
This study aims to investigate the impact of quantity-based and price-based monetary policy on corporate investment in India. Also the study investigates the impact of firm-level factors on corporate investment under quantity-based and price-based monetary policy.

Design/methodology/approach
The study is based on sample of 3,782 non-financial Indian firms (45,238 observations) and the data has been collected for a period 2000–2023. The study applies instrument variable approach to arrive at the results.

Findings
The study finds that both quantity-based and price-based monetary policy significantly affects corporate investment of firms and the transmission of monetary policy to corporate investment is constrained by firm-specific factors. This paper find that firm-specific factors play a significant role in transmitting the effects of both quantity-based as well as price-based monetary policy respectively and such results have also been witnessed across manufacturing and non-manufacturing sectors.

Originality/value
To the best of the authors’ knowledge, this is the first study in the Indian context that examines the impact of quantity-based and price-based monetary policy on corporate investment.
Multiple environmental regulations and green technology innovation: a boundary theory perspective
Authors: Luo Qingfeng , Zhao Xi 
Published: November 2024

Purpose
Based on boundary theory, the authors try to clarify the boundaries of multiple environmental regulations. This paper aims to explore the strategic choices of multiple environmental regulations, analyze their spatial impact on green technology innovation and clarify the implementation priorities of multiple environmental regulations in various regions.

Design/methodology/approach
The authors construct an asymmetric response model based on the boundary theory perspective to analyze the strategic choices of different environmental regulations. In addition, dynamic spatial econometric methods are used to empirically analyze the differentiated regulatory boundaries of command-control type, market-incentive and voluntary-participation in environmental regulations and their spatial effects on green technology innovation.

Findings
Strict compulsory boundaries are formed in China when the command-control and market-incentive types are selected in a dynamic spatial and competitive game environment. When voluntary participation is selected, strict compulsory or loose basic boundaries are formed in each region. The command-control type is highly dependent on geographical distance, the market-incentive type is more dependent on an economic connection and the voluntary-participation type has obvious spatial spillover effects under the spatial weight matrix of geographical distance and economic connection. When Eastern China chooses voluntary participation in environmental regulation, the incentive effect on green technology innovation is the strongest. Middle China is the market-incentive type, and Western China is the command-control type. Command-control type and market-incentive type form strong complementary effects in dynamic spatial environments.

Originality/value
From the boundary theory perspective, this study analyzes the differentiated dynamic spatial boundaries of command-control, market-incentive and voluntary-participation in environmental regulations. Analyze the spatial impact of multiple environmental regulations on green technology innovation and clarify the implementation priorities of multiple environmental regulations in various regions.
Disentangling direct and indirect effects of forest structure on biodiversity: Bottom‐up and top‐down effects between forestry, bats and their insect prey
Authors: Hendel Anna‐Lena , Douma Jacob C. , Klingenfuß Sara , Pereira João M. C. , Ruppert Laura , Spînu Andreea P. , Frey Julian , Denter Martin , Liu Xiang , Storch Ilse , Klein Alexandra M. , Braunisch Veronika 
Published: November 2024

Abstract

Timber‐oriented forest management profoundly alters forest structure and composition, with complex effects on associated biodiversity. However, while species' responses to forest management and resulting structural characteristics have been the subject of numerous studies, direct and indirect effects that cascade through trophic levels are rarely disentangled. As insectivorous bats are particularly sensitive to changes in forest structure, that shape their available flight space, we investigated how forest structure, composition and management also indirectly modify their habitats, for example, by affecting important insect prey groups.

We used structural equation models (SEMs) to test bat responses to forest composition, structure (forest heterogeneity, old‐growth attributes) and management intensity, quantifying direct and indirect prey‐mediated effects. For that, three bat guilds—short‐ (SRE), mid‐ (MRE) and long‐range echolocating (LRE) bats—and their prey insects (moths and ground beetles) were analysed from 64 sites in the Black Forest, Germany.

We found guild‐specific effects on bats: While the structural heterogeneity of forests directly influenced the activity of bat guilds, the main influence of forest management, composition and structure was mediated through their prey‐groups.

SRE activity responded to moths and LRE activity was associated with ground beetles, with positive effects of the insect groups' abundance, but negative effects of the same group's species richness. In addition, the SEM approach revealed a negative top‐down relationship between MRE activities and moths, suggesting predation or avoidance behaviour of moths.

While forest management directly or indirectly increased prey insect abundance, it negatively affected the availability of roosting structures for bats.

Synthesis and applications. The results highlight the indirect and positive effects of forest management on bats and support the important role of bats in insect regulation within continuous cover forests. Although forest management created small gaps that improved foraging habitats for most bats, it compromised the roosting functionality for bats. The ‘close‐to‐nature forestry’ currently prevalent in Europe mainly promotes continuous‐cover forests in mid‐successional stages. Expanding the forest management portfolio towards open and old‐growth forests would increase roosting opportunities and provide complementary foraging habitats for different bat species, while promoting high biodiversity in managed forest landscapes.
The context‐dependent benefits of organic farming on pollinator biodiversity: A meta‐analysis
Authors: Walker Emily , Wooliver Rachel , Russo Laura , Jagadamma Sindhu 
Published: November 2024

Abstract

Agricultural intensification is driving declines in pollinator diversity and the degradation of pollination services worldwide. Organic management, which prohibits the use of synthetic inputs, has considerable potential for combatting these declines by enhancing biodiversity in agricultural landscapes. However, the efficacy of organic farming for promoting pollinator diversity has recently been questioned.

We conducted a meta‐analysis to determine the effect of organic management on pollinator species richness and abundance. We compiled 42 studies across four continents and calculated a Hedges' g effect size for each of 76 species richness and 57 abundance observations. We then estimated average effect sizes overall and across five moderators.

Species richness and abundance of pollinating insects tended to be higher in organic farms than conventional ones, with average effect sizes of 0.68 and 0.74, respectively. Landscape context, crop type, pollinator group, sampling location, and sampling method were factors impacting the response of pollinator diversity/abundance to organic farming.

We found benefits for pollinator diversity from organic farming in all landscape types, with the strongest response in simple compared with more complex landscapes. Pollinator diversity benefited the most in habitats within organic cereal systems and the least in organic pastures. Among pollinator groups, bumblebee diversity benefitted the most, while moths and hoverflies showed positive but non‐significant responses. Higher pollinator diversity/abundance was detected in organic farms at various sampling locations. Transect sampling showed the greatest diversity gains among sampling methods.

Synthesis and applications. Our results affirm that organic farming has positive effects for pollinator species richness and abundance, but benefits are variable and not guaranteed. We recommend that future studies adopt a standard sampling protocol and cover a larger geographic range to understand the global potential of organic farming to promote pollinator biodiversity. Efforts to increase pollinator abundance and diversity through organic farming should focus on organic systems involving cereal phases, especially within simple landscapes, for the most positive outcomes. However, due to high variability in pollinator responses alongside the challenges to achieve economic profitability from organic farming, crafting organic farming systems to specific farm‐scale opportunities and needs may be necessary.
Lorlatinib overcomes alectinib‐induced hemolytic anemia in an ALK fusion positive non‐small‐cell lung cancer patient with severe tumor‐associated liver failure: A case report
Authors: Kunimasa Kei , Miyazaki Akito , Tamiya Motohiro , Inoue Takako , Kawamura Takahisa , Tanaka Tsunehiro , Futamura Shun , Komuta Kiyohide , Nagata Shigenori , Honma Keiichiro , Ohkawa Kazuyoshi , Nishino Kazumi 
Published: November 2024

AbstractHemolytic anemia is a rare and unique complication of alectinib, not observed with other anaplastic lymphoma kinase (ALK) inhibitors. Here, we present a case of an ALK fusion‐positive non‐small‐cell lung cancer (NSCLC) patient who developed liver failure due to diffuse liver metastasis at initial diagnosis. Treatment was initiated with low‐dose alectinib, but the patient developed severe hemolytic anemia. Switching to lorlatinib allowed for the continuation of ALK inhibitor therapy and successful tumor reduction. ALK inhibitors are crucial for ALK fusion‐positive NSCLC patients. Managing severe side effects by switching medications is essential to maintain effective therapy. In this case, lorlatinib effectively controlled the tumor and improved the patient's liver function and performance status. This case highlights the importance of adapting treatment strategies to manage adverse effects while ensuring the continued use of ALK inhibitors for optimal patient outcomes.
A meta‐analysis on racial discrimination and alcohol use among Asian Americans
Authors: Liu Melissa A. , Fox Taylor , Salyers Michelle , Zapolski Tamika , Cyders Melissa A. 
Published: November 2024

AbstractBackgroundRacial discrimination has been identified as a contributing risk factor for alcohol use among racially minoritized individuals. The aims of this study were to quantify the relationship between racial discrimination and alcohol use among Asian Americans, examine gender, age and generational status as moderators, and characterize ethnic group representation across the literature.MethodsA systematic literature search was conducted using PsycINFO, CINAHL, Web of Science, PubMed, Embase, and OpenDissertations. A random effects model using Pearson's r effect sizes was conducted on separate alcohol outcomes. Meta‐regression analyses tested for moderating effects, and heterogeneity was examined by identifying outliers and subgroup differences. Risk of bias was assessed using a funnel plot and Egger's regression test.ResultsTwenty‐two effect sizes were extracted from 18 studies, representing 8926 participants. A significant positive association was found between racial discrimination and alcohol consumption (k = 9, r = 0.13, 95% CI = [0.07, 0.19], I2 = 80.7%, p = 0.002) and problematic alcohol use (k = 12, r = 0.27, 95% CI = [0.12, 0.40] I2 = 93.7%, p = 0.002), but not binge use (k = 3, r = 0.08, 95% CI = [−0.49, 0.60], I2 = 95.0%, p = 0.64). Age, gender, and generational status were not significant moderators (p's > 0.10). When ethnic groups were reported, Chinese Americans were most represented (36.9%), while Indian Americans were notably underrepresented (1.18%).ConclusionsThere is a small positive association between racial discrimination and alcohol consumption and problematic alcohol use among Asian Americans. Research should seek to fill gaps identified by this review, including the dearth of longitudinal work needed to establish temporal precedence, the limited understanding of racial discrimination on binge use and underrepresented ethnic groups in this field of research, and reducing heterogeneity between studies.
Robotic surgery versus laparoscopic surgery for rectal cancer: a comparative study on surgical safety and functional outcomes
Authors: TengTeng Li , HaiXiao Fu , Wei Fu , Xuan Zhang 
Published: November 2024

AbstractBackgroundsThis study aims to evaluate the clinical efficacy and functional outcomes of DA Vinci (Xi)‐assisted surgery compared to conventional laparoscopic surgery for middle and low rectal cancer, focusing on oncologic cure and functional preservation.MethodsBetween December 2020 and June 2021, 102 patients with middle and low rectal cancer (tumour lower margin ≤10 cm) were enrolled at the affiliated Hospital of Xuzhou Medical University. Participants were divided into two groups: robot‐assisted (n = 51) and laparoscopy‐assisted (n = 51). Each group underwent a radical resection using their assigned method. Clinical and functional outcomes were analysed post‐surgery.ResultsPreoperative data did not differ significantly between groups (P > 0.05). All surgeries were successfully completed without conversion to open surgery. The robotic group experienced significantly less intraoperative blood loss (55.2 ± 29.8 mL vs. 109.5 ± 58.5 mL) and faster recovery in gastrointestinal function (35.1 ± 9.4 h vs. 40.7 ± 1.9 h), diet recovery (2.1 ± 0.8 days vs. 2.9 ± 0.4 days), and catheter removal (2.9 ± 2.7 days vs. 5.3 ± 2.1 days). The robotic group also dissected more lymph nodes (23 ± 6 vs. 15 ± 4). However, they had longer operative times (239.8 ± 29.6 min vs. 141.1 ± 18.5 min) and higher hospital costs. Satisfaction levels regarding defecation, voiding, and sexual functions were notably higher in the robotic group.ConclusionNo significant differences in surgical safety or immediate postoperative outcomes were observed between robotic and laparoscopic approaches. However, robotic surgery demonstrated superior lymph node dissection, anal function preservation, and gastrointestinal recovery, enhancing overall functional outcomes.
Parents' experiences of their children's obesity management at the children's hospital on Reunion Island
Authors: Lebleu Mary , Druilhe Loic , Palma Vanessa , Lebeau Jean‐Pierre 
Published: November 2024

AbstractAimParents' perspectives on their child's obesity (BMI >IOTF‐30) management are essential to ensure positive outcomes. This study explored parents' experiences in managing their children's obesity and investigated the sociocultural and environmental factors influencing such management on Reunion Island, a French overseas department in the Indian Ocean.MethodsThis qualitative study used a general inductive analysis approach. Semi‐structured telephone interviews were conducted from France, between January and April 2019, with nine parents of children treated in the Childhood Obesity Unit of the Children's Hospital on Reunion Island. The interviews were analysed by using thematic analysis until data saturation.ResultsFour main themes emerged reflecting the stages of parents' experiences during treatment: a life history with feelings of justification and guilt, acceptance, involvement and activism. Cultural food traditions were a barrier to implementing healthier habits. Support and advice from the healthcare services alleviated feelings of isolation and motivated parents to be more proactive in their children's obesity management. Parents' involvement motivated their children and improved their relationships.ConclusionsParent's involvement is essential in managing children's obesity. To maximise treatment outcomes, tailored interventions that address parents' unique family dynamics and sociocultural perspectives are key.