bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrent MSCE116K mutations in ALK-negative anaplastic large cell lymphoma
Authors: Luchtel Rebecca A. , Zimmermann Michael T. , Hu Guangzhen , Dasari Surendra , Jiang Manli , Oishi Naoki , Jacobs Hailey K. , Zeng Yu , Hundal Tanya , Rech Karen L. , Ketterling Rhett P. , Lee Jeong-Heon , Eckloff Bruce W. , Yan Huihuang , Gaonkar Krutika S. , Tian Shulan , Ye Zhenqing , Kadin Marshall E. , Sidhu Jagmohan , Jiang Liuyan , Voss Jesse , Link Brian K. , Syrbu Sergei I. , Facchetti Fabio , Bennani N. Nora , Slager Susan L. , Ordog Tamas , Kocher Jean-Pierre , Cerhan James R. , Ansell Stephen M. , Feldman Andrew L. 
Published: May 2019

AbstractAnaplastic large cell lymphomas (ALCLs) represent a relatively common group of T-cell non-Hodgkin lymphomas (T-NHLs) that are unified by similar pathologic features but demonstrate marked genetic heterogeneity. ALCLs are broadly classified as being anaplastic lymphoma kinase (ALK)+ or ALK−, based on the presence or absence of ALK rearrangements. Exome sequencing of 62 T-NHLs identified a previously unreported recurrent mutation in the musculin gene, MSCE116K, exclusively in ALK− ALCLs. Additional sequencing for a total of 238 T-NHLs confirmed the specificity of MSCE116K for ALK− ALCL and further demonstrated that 14 of 15 mutated cases (93%) had coexisting DUSP22 rearrangements. Musculin is a basic helix-loop-helix (bHLH) transcription factor that heterodimerizes with other bHLH proteins to regulate lymphocyte development. The E116K mutation localized to the DNA binding domain of musculin and permitted formation of musculin–bHLH heterodimers but prevented their binding to authentic target sequence. Functional analysis showed MSCE116K acted in a dominant-negative fashion, reversing wild-type musculin-induced repression of MYC and cell cycle inhibition. Chromatin immunoprecipitation–sequencing and transcriptome analysis identified the cell cycle regulatory gene E2F2 as a direct transcriptional target of musculin. MSCE116K reversed E2F2-induced cell cycle arrest and promoted expression of the CD30–IRF4–MYC axis, whereas its expression was reciprocally induced by binding of IRF4 to the MSC promoter. Finally, ALCL cells expressing MSCE116K were preferentially targeted by the BET inhibitor JQ1. These findings identify a novel recurrent MSC mutation as a key driver of the CD30–IRF4–MYC axis and cell cycle progression in a unique subset of ALCLs.
Winnicott: An Introduction
Authors: Phillips Adam 
Published: May 2019

“Health is much more difficult to deal with than disease.” D. W. WinnicottIIn a talk given in 1945 to the sixth form of St Paul's School, Donald Winnicott described his experience, as a schoolboy, of discovering Darwin'sOrigin of Species:“I could not leave off reading it. At the time I did not know why it was so important to me, but I see now that the main thing was that it showed that living things could be examined scientifically with the corollary that gaps in knowledge and understanding need not scare me. For me this idea meant a great lessening of tension and consequently a release of energy for work and play.” (Quoted in Davis & Wallbridge, 1983, p. 24.)
An Acute Care for Elders Quality Improvement Program for Complex, High‐Cost Patients Yields Savings for the System
Authors: Brennan Maura J , Knee Alexander B , Leahy Erin J , Ehresman Michael J , Courtney Heidi‐Ann , Coffelt Patricia , Stefan Mihaela S 
Published: May 2019

BACKGROUNDAcute Care for Elders (ACE) programs improve outcomes for older adults; however, little is known about whether impact varies with comorbidity severity.OBJECTIVETo describe differences in hospital‐level outcomes between ACE and routine care across various levels of comorbidity burden.DESIGNCross‐sectional quality improvement study.SETTINGA 716‐bed teaching hospital.PARTICIPANTSMedical inpatients aged ≥70 years hospitalized between September 2014 and August 2017.INTERVENTIONACE care, including interprofessional rounds, geriatric syndromes screening, and care protocols, in an environment prepared for eldersMEASUREMENTSTotal cost, length of stay (LOS), and 30‐day readmissions. We calculated median differences for cost and LOS between ACE and usual care and explored variations across the distribution of outcomes at the 25th, 50th, 75th and 90th percentiles. Results were also stratified across quartiles of the combined comorbidity score.RESULTSA total of 1,429 ACE and 10,159 non‐ACE patients were included in this study. The mean age was 81 years, 57% were female, and 81% were white. ACE patients had lower costs associated with care ranging from $171 at the 25th percentile to $3,687 at the 90th percentile, as well as lower LOS ranging from 0 days at the 25th percentile to 1.9 days at the 90th percentile. After stratifying by comorbidity score, the greatest differences in outcomes were among those with higher scores. There was no difference in 30‐day readmission between the groups.CONCLUSIONThe greatest reductions in cost and LOS were in patients with greater comorbidity scores. Risk stratification may help hospitals prioritize admissions to ACE units to maximize the impact of the more intensive intervention.
Achievable Benchmarks of Care for Pediatric Readmissions
Authors: Montalbano Amanda , Quiñonez Ricardo A , Hall Matt , Morse Rustin , Ishman Stacey L , Antoon James W , Gold Jessica , Teufel Ronald J , MD Vineeta Mittal , Shah Samir S , Parikh Kavita 
Published: May 2019

BACKGROUNDMost inpatient care for children occurs outside tertiary children's hospitals, yet these facilities often dictate quality metrics. Our objective was to calculate the mean readmission rates and the Achievable Benchmarks of Care (ABCs) for pediatric diagnoses by different hospital types: metropolitan teaching, metropolitan nonteaching, and nonmetropolitan hospitals.METHODSWe used a cross‐sectional retrospective study of 30‐day, all‐cause, same‐hospital readmission of patients less than 18 years old using the 2014 Healthcare Utilization Project National Readmission Database. For each hospital type, we calculated the mean readmission rates and corresponding ABCs for the 17 most common readmission diagnoses. We define outlier as any hospital whose readmission rate fell outside the 95% CI for an ABC within their hospital type.RESULTSWe analyzed 690,949 discharges at 525 metropolitan teaching hospitals (550,039 discharges), 552 metropolitan nonteaching hospitals (97,207 discharges), and 587 nonmetropolitan hospitals (43,703 discharges). Variation in readmission rates existed among hospital types; however, sickle cell disease (SCD) had the highest readmission rate and ABC across all hospital types: metropolitan teaching hospitals 15.7% (ABC 7.0%), metropolitan nonteaching 14.7% (ABC 2.6%), and nonmetropolitan 12.8% (ABC not calculated). For diagnoses in which ABCs were available, outliers were prominent in bipolar disorders, major depressive disorders, and SCD.CONCLUSIONSABCs based on hospital type may serve as a better metric to explain case‐mix variation among different hospital types in pediatric inpatient care. The mean rates and ABCs for SCD and mental health disorders were much higher and with more outlier hospitals, which indicate high‐value targets for quality improvement.
How Much Time are Physicians and Nurses Spending Together at the Patient Bedside?
Authors: Sang Adam X , Tisdale Rebecca L , Nielsen Derek , Loica‐Mersa Silvia , Miller Travis , Chong Ian , Shieh Lisa 
Published: May 2019

BACKGROUNDBedside rounding involving both nurses and physicians has numerous benefits for patients and staff. However, precise quantitative data on the current extent of physician–nurse (MD–RN) overlap at the patient bedside are lacking.OBJECTIVEThis study aimed to examine the frequency of nurse and physician overlap at the patient beside and what factors affect this frequency.DESIGNThis is a prospective, observational study of time‐motion data generated from wearable radio frequency identification (RFID)‐based locator technology.SETTINGSingle‐institution academic hospital.MEASUREMENTSThe length of physician rounds, frequency of rounds that include nurses simultaneously at the bedside, and length of MD–RN overlap were measured and analyzed by ward, day of week, and distance between patient room and nursing station.RESULTSA total of 739 MD rounding events were captured over 90 consecutive days. Of these events, 267 took place in single‐bed patient rooms. The frequency of MD–RN overlap was 30.0%, and there was no statistical difference between the three wards studied. Overall, the average length of all MD rounds was 7.31 ± 0.58 minutes, but rounding involving a bedside nurse lasted longer than rounds with MDs alone (9.56 vs 5.68 minutes, P < .05). There was no difference in either the length of rounds or the frequency of MD–RN overlap between weekdays and weekends. Finally, patient rooms located farther away from the nursing station had a lower likelihood of MD–RN overlap (Pearson's r = –0.67, P < .05).CONCLUSIONRFID‐based technology provides precise, automated, and high‐throughput time‐motion data to capture nurse and physician activity. At our institution, 30.0% of rounds involve a bedside nurse, highlighting a potential barrier to bedside interdisciplinary rounding.
Supply Chain Proximity and Product Quality
Authors: Bray Robert L. , Serpa Juan Camilo , Colak Ahmet 
Published: May 2019

We estimate the effect of supply chain proximity on product quality. Merging four automotive data sets, we create a supply chain sample that reports the failure rate of 27,807 auto components, the location of 529 upstream component factories, and the location of 275 downstream assembly plants. We find that defect rates are higher when upstream and downstream factories are farther apart. Specifically, we estimate that increasing the distance between an upstream component factory and a downstream assembly plant by an order of magnitude increases the component’s expected defect rate by 3.9%. We find that quality improves more slowly across geographically dispersed supply chains. We also find that supply chain distance is more detrimental to quality when automakers produce early-generation models or high-end products, when they buy components with more complex configurations, or when they source from suppliers who invest relatively little in research and development.This paper was accepted by Vishal Gaur, operations management.
Get Noticed and Die Trying: Signals, Sacrifice, and the Production of Face Time in Distributed Work
Authors: Cristea Ioana C. , Leonardi Paul M. 
Published: May 2019

Research shows that displaying face time—being observed by others at work—leads to many positive outcomes for employees. Drawing on this prior work, we argue that face time helps employees to receive better work and leads to career advancement because it is a strong signal of their commitment to their job, their team, and their organization. But when employees are geographically distributed from managers who control the assignment of work, they are often unable to display face time. To compensate, employees must engage in other behaviors that signal commitment. Our study of two large, globally distributed, product-development companies demonstrates that employees who engage in certain behaviors can effectively signal their commitment to the organization and, as a consequence, will receive better work assignments. But because they operate in a competitive signaling environment, they have to continually engage in the behaviors that produce desired signals to the point where they often feel that they are sacrificing their personal lives for their job. We induct a model from our data that explains why simple behaviors that signal commitment eventually turn into feelings of sacrifice and why employees at headquarters who have the power to assign better work fail to notice the sacrifice behind the signals. We discuss the implications of this model and the signal misalignment it explains for theories of distributed work and signaling in organizations. The online appendix is available at https://doi.org/10.1287/orsc.2018.1265 .
Conscious sedation and reduction of fractures in the paediatric population: An orthopaedic perspective
Authors: Yang B. W. , Waters P. M. 
Published: May 2019

Purpose Closed reduction under conscious sedation in the emergency department (ED) has been demonstrated to provide cost-effective, timely care. There has been little research into the efficacy of conscious sedation and reduction from an orthopaedic trauma perspective. This study describes the epidemiology and outcomes associated with fracture conscious sedation and reduction in our level I paediatric ED. Methods All fracture patients presenting overnight to our level I trauma centre ED between 01 June 2016 and 30 June 2017 were identified. Patient records were reviewed to determine diagnoses, treatments and outcomes. The rate of repeat intervention after successful conscious sedation and reduction and rate of changes in management in which the orthopaedic resident's overnight management plan to provide procedural sedation was altered to surgical intervention after morning case review rounds was calculated. Results Conscious sedation and reduction was performed on a total of 386 patients covering ten fracture types during the course of our study, with distal radius fractures (n = 167, 43.3%) comprising the majority of cases. A total of 53 cases (13.7%, 53/386) lost alignment and required repeat intervention, consisting of 33 cases (8.5%, 33/386) that required repeat surgery and 5.2% (20/386) that required cast wedging. In all, 12 patients (3.1%, 12/386) initially reduced under conscious sedation required a change in management and surgical intervention. There were five cases of growth arrest and two cases of malunion. Conclusions Conscious sedation and reduction provides an alternative to general anaesthesia for many paediatric trauma injuries without compromising patient outcomes Level of Evidence IV
Concept of Planning Development of Coastal Resort Settlements under Conditions of Complex Relief
Authors: FINOGENOV Alexandr Ivanovich , POPOV Aleksey Vladimirovich 
Published: May 2019

The scientific concept of planning development of small cities and settlements located on the coast of the Crimea peninsula of the Black Sea is outlined. The relevance of the study is due to the importance of the territory in question as the All-Russian Center for Mass Recreation, Tourism and Sport.
Subject: The principles of planning organization of modern urban development and objects of transport communications under conditions of complex relief on the territory of coastal settlements of Crimea (on the example of optimizing the urban planning structure of Gurzuf urban-type settlement).
Purposes: Development of scientific concept in the field of urban planning reorganization of the territory of small urban coastal settlements with the formation of new centers for the public, educational, hotel and transport-communal use. Improving the structure of urban development and objects of transport infrastructure.
Methods: The concept is based on a comprehensive analysis of the process of historical exploration and development of the coastal settlements’ territories of the Crimean Peninsula under the conditions of complex relief and ineffective development. The new methods of step-by-step reorganization of urban space are proposed.
Results: The concept determines further practical directions in the field of design, concerning the improvement of the planning structure of buildings within the boundaries of small urban settlements in Crimea, the creation of the spatially organized structure of new urban facilities for the public, hotel-tourism, educational and transport-communal use. The new methods of step-by-step reorganization of the structure of buildings and transport communications, ensuring the availability of facilities for mass resort recreation and tourism, sustainable public and transport links, preservation of the unique ecology of the Crimean resort zone are proposed.
Investigating the Effect of Service Quality, Mental Image, Trust and Environment Brand on Emotional Satisfaction and Commitment
Authors: SHIRI Yousef Mirzaei , ALIPOOR Vahideh , AZIMI Hossein 
Published: May 2019

The superior service quality enables an economic unit to distinguish itself from other competitors and compared with them, gain a series of competitive advantages. Increasing the service quality will increase customer satisfaction, followed by increasing positive word of mouth (WOM), reduced staff turnover and improved financial performance of the company. The aim of this study is to find the relationship between different elements of long-term cooperation between banks and customers. The research method is a survey-descriptive research and data collection tool is a standardized questionnaire that is localized and its reliability and validity have been reaffirmed. The statistical society of this study was all customers of Tejarat, Saderat, Eghtesade Novin banks in Zanjan and the questionnaires were distributed randomly among 400 customers of these banks. The conceptual model of the research processed using the structural equation model in PLS software. Findings showed that quality of services, mental image, trust and environment brand have a positive effect on customer satisfaction and emotional commitment. Also, customer satisfaction and emotional commitment have a positive effect on behavioral tendencies.
Spatio-Temporal Zoning of the Urban Lands’ Functioning for Ensuring the Sustainable Development of the City
Authors: ROGATNEV Yuri Mikhailovich , SCHERBA Valentina Nikolaevna , NAZAROVA Olga Sergeevna , FILIPPOVA Tatyana Anatolevna , DOLMATOVA Olga Nikolaevna 
Published: May 2019

The problems of the modern land use development in the cities located in the oil and gas producing Siberian regions of Russia are reviewed in the article. The modern scientific ideas about the role of the modern land and property assets in small and medium-sized cities in adverse climatic living environment are explored for this purpose.
The study is aimed at improving the method for assessing the current organization of the land use in the municipal city of Nefteyugansk. The methodological provisions of land zoning with due consideration for its socioeconomic value and temporal changes are developed. The methodological provisions for a comprehensive assessment of the land use conditions aimed at using the spatio-temporal land zoning model are improved.
The results of the study can be used in the practice of local authorities and legal entities in urban planning, land and property relations, housing and utility services in territorial planning, development of land and property relations in the market conditions, improvement of the land payment system, determination of the land investment attractiveness, and creation of a unified basis for an objective land plot evaluation. The introduction of the results of the study into practice will allow to increase the efficiency of the land use, increase its value, and bring the socioeconomic indicators of the land and property assets of the city to a higher level.
Community-engaged research through the lens of school closures: Opportunities, challenges, contributions, and lingering questions
Authors: Agard Claudette , Ansari Zakiyah , Conner Jerusha , Ferman Barbara , Pappas Liza N. , Shiller Jessica 
Published: May 2019

This article expands upon and problematizes the practice of community-engaged research (CES) through the lens of school closings. Rather than employ a one-dimensional view of CES that portrays university researchers and community partners as collaborating equally on all stages of the research, we suggest a broader, more flexible understanding that incorporates various contextual factors. Drawing on local examples, from New York City and Baltimore, and one national effort to resist school closings, we present three forms of CES: participatory action research (PAR), in which university researchers and community partners collaboratively engaged in almost all aspects of the process; the engaged learner, in which the researcher documented a community organizing campaign with the full support of the campaign organizers; and a grassroots listening project implemented without university partners. In each case, participants had to navigate the thorny issues of power differentials, race and racism, ownership and voice, and presentation and representation. Difficulties notwithstanding, CES has made important contributions to both the literature on and practice of school closings. We conclude the article with a discussion of some of the lingering tensions that characterize community-engaged scholarship.
Towards a usage-based model of early code-switching: Evidence from three language pairs
Authors: Gaskins Dorota , Frick Maria , Palola Elina , Endesfelder Quick Antje 
Published: May 2019

AbstractUsage-based studies trace children’s early language back to slot-and-frame patterns which dominate spontaneous language use. We apply the Traceback method to data from three bilingual children with English as one of their languages and Polish, German, or Finnish as the other to examine what these children’s code-switching has in common and how it differs in light of the genealogical distance between the languages used. Their bilingual constructions are derived from individual corpora of naturalistic interactions of each child respectively and traced back to monolingual language produced previously to establish whether they are unprocessed chunks or partially schematic units. Based on this, we propose a model of switching which helps us to distinguish between the qualitative aspects of bilingual use in these two types of combinations. Our results show that all three children filter out some mixing occurring in chunks before these give basis to longer units. Whatever bilingual combinations remain frozen in those units can be explained by phonological overlap of the children’s two languages, which is highest in the acquisition of English-German due to their genealogical proximity.
A State Estimation Method Based on Integration of Linear and Extended Kalman Filters
Authors: Farsi M. , Dehghan Manshadi M. 
Published: May 2019

Abstract
The Linear Kalman Filter (LKF) and Extended Kalman Filter (EKF) as correction-prediction observers are two common model-based filters, which are widely used to estimate the unmeasurable states and parameters in the chemical processes. The main disadvantages of LKF and EKF are low accuracy and reliability of estimation and high computational time, respectively. The main object of this work is the modification of conventional Kalman filter to cover the disadvantages of LKF and EKF. The proposed method is planned based on the systematic updating the Jacobian matrix of estimator applied on the nonlinear systems. In this regard, a linearity index is defined based on the characteristics of outputs to determine switching time between LKF and EKF to avoid unnecessary updating the Jacobian matrix. The performance of the proposed method is compared with the LKF and EKF considering four chemical benchmarks as the nonlinear state space models. Altought EKF and proposed filter present similar precision to estimate unmeasurable states, the proposed method has a lower computational time.
Synthesis of polycyclic phosphonates via an intramolecular Diels-Alder reaction of 2-benzoylbenzalaldehyde and alkenyl phosphites
Authors: Yamana Kenji , Nakano Hirofumi 
Published: May 2019

AbstractIn this paper, we present a Lewis-acid-promoted reaction of 2-benzoylbenzaldehyde and trialkenyl phosphites, which resulted in the formation of polycyclic phosphonates. The reaction proceeded via nucleophilic attack of trialkenyl phosphite on the carbonyl carbon of 2-benzoylbenzaldehyde. The subsequent intramolecular Diels-Alder reaction led to the formation of the cyclic phosphonate.