bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal Blood Pressure, Cord Glucocorticoids, and Child Neurodevelopment at 2 Years of Age: A Birth Cohort Study
Authors: Liu Qi , Jin Shuna , Sun Xiaojie , Sheng Xia , Mao Zhenxing , Jiang Yangqian , Liu Hongxiu , Hu Chen , Xia Wei , Li Yuanyuan , Xu Shunqing 
Published: February 2019

Abstract

BACKGROUND
Pregnancy hypertensive disorders have impaired neurodevelopment in offspring. We aimed to explore the association of normal range maternal blood pressure (BP) with child neurodevelopment, as well as the possible role of placental 11-beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2) therein.

METHODS
Among 1,008 mother–child pairs recruited in Wuhan, China, in 2013–2015, we measured maternal third-trimester BP (systolic BP (SBP) and diastolic BP (DBP)) and cord glucocorticoids (cortisol and cortisone), a marker reflecting placental 11β-HSD2 activity. We evaluated child neurodevelopment using the Bayley Scales of Infant Development (BSID) with obtaining the Mental and Psychomotor Development Index (MDI and PDI). Multiple regression and mediation analysis were performed to estimate the effect.

RESULTS
Each 5 mm Hg increase in maternal third-trimester SBP was associated with 1.54 points decrease in MDI (95% confidence interval (CI) = –2.60, –0.48) and 1.23 points decrease in PDI (95% CI = –2.14, –0.31); similar association was observed between DBP and BSID (adjusted β = –1.32; 95% CI = –2.53, –0.10 for MDI and –1.37; 95% CI = –2.42, –0.33 for PDI). Also, we found significant associations between cord cortisol/cortisone ratio and PDI (adjusted β = 2.95; 95% CI = 0.91, 4.99), as well as between maternal BP and cord cortisol/cortisone ratio (adjusted β = –0.03; 95% CI = –0.06, –0.01 for both SBP and DBP). Mediation analysis revealed that cord cortisol/cortisone ratio explained 6.29% of the association between SBP and PDI, and 6.85% between DBP and PDI.

CONCLUSIONS
Increased maternal normal range BP may affect child neurodevelopment. Furthermore, placental 11β-HSD2 activity might be involved in the process.
The spectre of triviality
Authors: Charlow Nate 
Published: February 2019

Abstract
A spectre haunts the semantics of natural language – the spectre of Triviality. Semanticists (in particular Rothschild 2013; Khoo and Mandelkern forthcoming-a, forthcoming-b) have entered into a holy alliance to exorcize this spectre. None, I will argue, have yet succeeded.
Measurement of Diacetyl and 2,3-Pentanedione in the Coffee Industry Using Thermal Desorption Tubes and Gas Chromatography–Mass Spectrometry
Authors: Pengelly Ian , O’Shea Hannah , Smith Gordon , Coggins Marie A 
Published: February 2019

Abstract
Diacetyl is a potentially harmful chemical that is used as an artificial flavouring in the food industry and may also be generated during processing of some natural products including coffee. In Europe, an 8-h time weighted average occupational exposure limit (TWA-OEL) of 20 ppb has been adopted for diacetyl, together with a short-term exposure limit (STEL) of 100 ppb. A new measurement method involving sampling on thermal desorption tubes and analysis by gas chromatography–mass spectrometry has been used to investigate potential exposure to diacetyl, and the related compound 2,3-pentanedione, at eight companies involved in the coffee industry including large- and small-scale manufacturers and coffee shops. A total of 124 static and personal samples were collected. In the majority of personal samples airborne concentrations of diacetyl were <5 ppb, with those at coffee shops generally <1 ppb. However, diacetyl concentrations in ~40% of the long-term personal samples, mainly originating from one site, were found to be in excess of the newly adopted European TWA-OEL of 20 ppb. Diacetyl concentrations up to 400 ppb were detected on the static samples, with the highest values occurring during grinding of roasted coffee beans. 2,3-Pentanedione was also detected in most of the samples at airborne concentrations around half of those for diacetyl. A significant number of other volatile organic compounds (VOCs) were also detected at sub-ppm concentrations, including acetoin, aliphatic carboxylic acids, aldehydes, ketones and esters, methylfuran, furfural and furfuryl-based alcohols and ketones, and nitrogen containing compounds, such as pyridines and pyrazines. In laboratory tests, diacetyl emissions generated during heating of whole beans were found to be significantly lower than those from heating the same beans after grinding. Diacetyl emissions from both ground and whole beans were also found to be significantly dependent on temperature.
Is size an issue of time? Relationship between the duration of xylem development and cell traits
Authors: Buttò Valentina , Rossi Sergio , Deslauriers Annie , Morin Hubert 
Published: February 2019

Abstract

Background and Aims
Secondary growth is a process related to the formation of new cells that increase in size and wall thickness during xylogenesis. Temporal dynamics of wood formation influence cell traits, in turn affecting cell patterns across the tree ring. We verified the hypothesis that cell diameter and cell wall thickness are positively correlated with the duration of their differentiation phases.

Methods
Histological sections were produced by microcores to assess the periods of cell differentiation in black spruce [Picea mariana (Mill.) B.S.P.]. Samples were collected weekly between 2002 and 2016 from a total of 50 trees in five sites along a latitudinal gradient in Quebec (Canada). The intra-annual temporal dynamics of cell differentiation were estimated at a daily scale, and the relationships between cell traits and duration of differentiation were fitted using a modified von Bertalanffy growth equation.

Key Results
At all sites, larger cell diameters and cell wall thicknesses were observed in cells that experienced a longer period of differentiation. The relationship was a non-linear, decreasing trend that occasionally resulted in a clear asymptote. Overall, secondary wall deposition lasted longer than cell enlargement. Earlywood cells underwent an enlargement phase that lasted for 12 d on average, while secondary wall thickness lasted 15 d. Enlargement in latewood cells averaged 7 d and secondary wall deposition occurred over an average of 27 d.

Conclusions
Cell size across the tree ring is closely connected to the temporal dynamics of cell formation. Similar relationships were observed among the five study sites, indicating shared xylem formation dynamics across the entire latitudinal distribution of the species.The duration of cell differentiation is a key factor involved in cell growth and wall thickening of xylem, thereby determining the spatial variation of cell traits across the tree ring.
‘Role Over’ or Roll Over? Dirty Work, Shift and Mental Health Act Assessments
Authors: Vicary Sarah , Young Alys , Hicks Stephen 
Published: February 2019

Abstract
The rise in numbers of applications for people being formally detained in hospital is one of the reasons given for the independent review of the Mental Health Act in England and Wales. These figures have led to concerns that the legislation might be flawed, including in relation to the process of Mental Health Act Assessments. Discussed in this article are two of the roles involved: the doctor who is responsible for conducting a medical assessment and the Approved Mental Health Professional (AMHP) who is responsible for assessing the social circumstances and in addition making the application. Using data from a study into AMHPs and the lens of the sociological theory ‘dirty work’, we discuss shift, an aspect of dirty work not yet applied in this context. We focus on AMHPs’ perceptions of the behaviour of doctors as encapsulated in the verbatim phrase ‘role over’. We argue that AMHPs, including social workers, justify or, to play on the words of the verbatim quote, roll over. This finding adds to the understanding of behaviour as it is understood within psychiatric occupations, including social work, during Mental Health Act Assessments.
Keeping the Boss Happy: Black and Minority Ethnic Students’ Accounts of the Field Education Crisis
Authors: Srikanthan Sinthu 
Published: February 2019

Abstract
Social work field education, the mandatory, practice-based component of accredited schools of social work, is in a state of crisis. Welfare state retrenchment has reduced the social and health service sectors’ capacity to provide field education placements. Concurrently, increasing student enrollment in and the expansion of social work programmes in the academy have increased the demand for field education. Whilst the service and academic sectors have developed a range of formal and informal relationships to cope with the crisis that often benefit workers in both domains, the implications for students, especially those who are Black and Minority Ethnic (BME), remain largely unknown. This article reports findings from institutional ethnographic research based on textual analyses and interviews with five BME students from a school of social work in Southern Ontario who were engaged in securing field education placement. A central finding of the study was that racial categories and hierarchies are reproduced across placement settings and in the sorting process of students into placement settings itself, adding to the work of BME social work students. The findings implicate the institutional practices and context of field education in the production of a racially stratified labour market in social work field education.
Adverse Childhood Experiences: Beyond Signs of Safety; Reimagining the Organisation and Practice of Social Work with Children and Families
Authors: Spratt Trevor , Devaney John , Frederick John 
Published: February 2019

Abstract
While an adverse childhood experience (ACE)-informed approach to child protection and welfare has become influential in USA, it has had markedly less influence in UK, this despite growth in adoption of ACE research as a basis for understanding population needs and aligning service delivery amongst policymakers and other professional groups. In this article, we note the development of ACE research and draw out implications for social work with children and families. We argue that current organisational and practice preoccupations, drawing on the example of the Signs of Safety programme, together with antipathy to ACEs in some quarters of the social work academy, have the effect of reifying a short-term and occluded view of the developing child’s needs so as to obstruct the systemic analysis and changes necessary to ensure that the child welfare system is redesigned to meet such needs. This suggests that post-Kempe era child welfare services are no longer conceptually or systemically adequate to protect children beyond immediate safety outcomes and consequently we need to reimagine their future.
Identification and validation of a potent multi-mRNA signature for the prediction of early relapse in hepatocellular carcinoma
Authors: Cai Jie , Tong Ying , Huang Lifeng , Xia Lei , Guo Han , Wu Hailong , Kong Xiaoni , Xia Qiang 
Published: February 2019

Abstract
Early recurrence of hepatocellular carcinoma (HCC) is implicated in poor patient survival and is the major obstacle to improving prognosis. The current staging systems are insufficient for accurate prediction of early recurrence, suggesting that additional indicators for early recurrence are needed. Here, by analyzing the gene expression profiles of 12 Gene Expression Omnibus data sets (n = 1533), we identified 257 differentially expressed genes between HCC and non-tumor tissues. Least absolute shrinkage and selection operator regression model was used to identify a 24-messenger RNA (mRNA)-based signature in discovery cohort GSE14520. With specific risk score formula, patients were divided into high- and low-risk groups. Recurrence-free survival within 2 years (early-RFS) was significantly different between these two groups in discovery cohort [hazard ratio (HR): 7.954, 95% confidence interval (CI): 4.596–13.767, P < 0.001], internal validation cohort (HR: 8.693, 95% CI: 4.029–18.754, P < 0.001) and external validation cohort (HR: 5.982, 95% CI: 3.414–10.480, P < 0.001). Multivariable and subgroup analyses revealed that the 24-mRNA-based classifier was an independent prognostic factor for predicting early relapse of patients with HCC. We further developed a nomogram integrating the 24-mRNA-based signature and clinicopathological risk factors to predict the early-RFS. The 24-mRNA-signature-integrated nomogram showed good discrimination (concordance index: 0.883, 95% CI: 0.836–0.929) and calibration. Decision curve analysis demonstrated that the 24-mRNA-signature-integrated nomogram was clinically useful. In conclusion, our 24-mRNA signature is a powerful tool for early-relapse prediction and will facilitate individual management of HCC patients.
Successful Control of Streptococcus pneumoniae 19A Replacement With a Catch-up Primary Vaccination Program in Taiwan
Authors: Lu Chun-Yi , Chiang Chuen-Sheue , Chiu Cheng-Hsun , Wang En-Tzu , Chen Ying-Yan , Yao Shu-Man , Chang Luan-Yin , Huang Li-Min , Lin Tzou-Yien , Chou Jih-Haw 
Published: February 2019

Abstract

Background
Streptococcus pneumoniae infections in Taiwan mostly occur in children aged 2–4 years. Because of a significant increase in the incidence of serotype 19A-related infections, the 13-valent pneumococcal conjugate vaccine (PCV13) was initially introduced in the national immunization program for children 2–5 years of age, prior to the national programs for infants. We have assessed the impact of such vaccination programs in reducing the incidence of invasive pneumococcal disease (IPD) in Taiwanese children.

Methods
We analyzed the national data on IPDs from the Taiwan Centers for Disease Control between 2008 and 2017. We calculated the incidence rates of IPD and incidence rate ratios (IRRs) between years for different serotypes to estimate the effectiveness of the vaccination programs.

Results
The national catch-up primary vaccination schedule successfully reduced the incidence rate of IPD from 17.8/100 000 in 2012 to 5.5/100 000 in 2017 among children aged 0–5 years. The IRR (2017 over 2012) was 0.31, corresponding to a 69% reduction. A modest herd effect was also observed, with a 37% reduction in the incidence of IPD in elderly people (≥70 years) from 2012 to 2017. The incidence of IPD caused by serotype 19A in children aged 0–5 years was reduced by 32.6–44.3% yearly from 2012 to 2017. In 2015, serogroup 15 outnumbered 19A, to become the leading serotypes in children 0–5 years old.

Conclusions
Special catch-up vaccination programs starting from children 2–5 years of age with PCV13 have been highly effective in reducing the incidence of IPD, especially as caused by serotype 19A, in Taiwanese children.
Persistent Low-level Viremia While on Antiretroviral Therapy Is an Independent Risk Factor for Virologic Failure
Authors: Joya Christie , Won Seung Hyun , Schofield Christina , Lalani Tahaniyat , Maves Ryan C , Kronmann Karl , Deiss Robert , Okulicz Jason , Agan Brian K , Ganesan Anuradha 
Published: February 2019

Abstract

Background
Whether persistent low-level viremia (pLLV) predicts virologic failure (VF) is unclear. We used data from the US Military HIV Natural History Study (NHS), to examine the association of pLLV and VF.

Methods
NHS subjects who initiated combination antiretroviral therapy (ART) after 1996 were included if they had 2 or more VLs measured with a lower limit of detection of ≤50 copies/mL. VF was defined as a confirmed VL ≥200 copies/mL or any VL >1000 copies/mL. Participants were categorized into mutually exclusive virologic categories: intermittent LLV (iLLV) (VL of 50–199 copies/mL on <25% of measurements), pLLV (VL of 50–199 copies/mL on ≥25% of measurements), high-level viremia (hLV) (VL of 200–1000 copies/mL), and continuous suppression (all VL <50 copies/mL). Cox proportional hazards models were used to evaluate the association between VF and LLV; hazard ratios and 95% confidence interval (CI) are presented.

Results
Two thousand six subjects (median age 29.2 years, 93% male, 41% black) were included; 383 subjects (19%) experienced VF. After adjusting for demographics, VL, CD4 counts, ART regimen, prior use of mono or dual antiretrovirals, and time to ART start, pLLV (3.46 [2.42–4.93]), and hLV (2.29 [1.78–2.96]) were associated with VF. Other factors associated with VF include black ethnicity (1.33 [1.06–1.68]) and antiretroviral use prior to ART (1.79 [1.34–2.38]). Older age at ART initiation (0.71 [0.61–0.82]) and non-nucleoside reverse transcriptase inhibitor (0.68 [0.51–0.90]) or integrase strand transfer inhibitor use (0.26 [0.13–0.53]) were protective.

Conclusion
Our data add to the body of evidence that suggests persistent LLV is associated with deleterious virologic consequences.
Seroprotection at Different Levels of the Healthcare System After Routine Vaccination With Diphtheria-Tetanus-Pertussis whole cell–Hepatitis B–Haemophilus influenzae Type B in Lao People’s Democratic Republic
Authors: Hefele Lisa , Syphan Sengdavanh , Xayavong Dalouny , Homsana Anousin , Kleine Daria , Chanthavilay Phetsavanh , Nouanthong Phonethipsavanh , Xaydalasouk Kinnaly , Phathammavong Outavong , Billamay Somxay , Xeuatvongsa Anonh , Reinharz Daniel , Muller Claude P , Black Antony P 
Published: February 2019

Abstract

Background
The Lao People’s Democratic Republic continues to sustain a considerable burden of vaccine-preventable diseases because of incomplete vaccine coverage and weak vaccine responses. We have assessed seroconversion after routine vaccination with the pentavalent vaccine to capture weaknesses of vaccine management at the different levels of the healthcare system.

Methods
A total of 1151 children (aged 8–28 months) with 3 documented doses of the pentavalent vaccine delivered at central hospitals in Vientiane and the provincial hospital, 3 district hospitals, and 10 health centers in Bolikhamxay province were enrolled. Sociodemographic information was collected with a standardized questionnaire. Serum samples were analyzed for antibodies against vaccine components, and bivariate and multivariable analyses were performed to identify risk factors for low vaccine responses.

Results
Seroprotection rates at the provincial, district, and health center level were as high as in central hospitals, but seroprotection rates in areas covered by remote health centers were significantly lower. Protective levels also rapidly decreased with age at sampling. Seroprotection rates in Bolikhamxay against the different components reached 70%–77% and were up to 20% higher than in previous studies in the same region; 18.8% more children received the hepatitis B vaccine birth dose and the hepatitis B virus infection rate was 4 times lower.

Conclusions
Vaccine immunogenicity has dramatically improved in a central province, likely due to training and investment in the cold chain. Nevertheless, there remains a need to focus on the “last mile” in remote areas were most children are vaccinated through outreach activities.
Higher albumin:creatinine ratio and lower estimated glomerular filtration rate are potential risk factors for decline of physical performance in the elderly: the Cardiovascular Health Study
Authors: Bůžková Petra , Barzilay Joshua I , Fink Howard A , Robbins John A , Cauley Jane A , Ix Joachim H , Mukamal Kenneth J 
Published: February 2019

Abstract

Introduction
Mildly reduced renal function and elevated urine protein levels are each prospectively associated with hip fracture risk in older adults. Here we determine whether these markers are associated with reduced appendicular muscle performance.

Methods
We prospectively examined the associations of urine albumin:creatinine ratio (ACR) and reduced estimated glomerular filtration rate (eGFR) with longitudinal changes in grip strength and gait speed &gt;2 years in 2317 older community-dwelling men and women (median age 77 years). The median ACR was 9.8 [interquartile range (IQR) 5.40–21.50] mg/g creatinine and the median eGFR was 71.6 (IQR 59.1–83.56) mL/min/1.73 m2. Models were adjusted for demographic factors, clinical history and biochemical measures in four candidate pathways: diabetes, oxidative stress, inflammation and fibrosis.

Results
In demographic- and covariate-adjusted models, a 2-fold higher baseline urine ACR was associated with longitudinal changes of −0.17 kg [95% confidence interval (CI) −0.29 to −0.06) in grip strength and −1.10 cm/s (95% CI −1.67 to −0.53) gait speed per year. Corresponding estimates for a 10 mL/min/1.73 m2 lower baseline eGFR were −0.13 kg (95% CI −0.23 to −0.04) and −0.89 cm/s (95% CI −1.37 to −0.40), respectively. The associations of a 2-fold higher baseline ACR and a 10 mL/min/1.73 m2 lower baseline eGFR using cystatin C with grip strength and gait speed were equivalent to ∼1.2–1.9 additional years of age. Adjustment for covariates in candidate pathways did not attenuate these estimates.

Conclusions
In older adults, higher ACR and lower eGFR are potential risk factors for a decline of physical performance &gt;2 years.
Fast methods for finding significant motifs on labelled multi-relational networks
Authors: Micale Giovanni , Pulvirenti Alfredo , Ferro Alfredo , Giugno Rosalba , Shasha Dennis 
Published: February 2019

Abstract
A labelled multi-relational network (or labelled multigraph, for short) is one in which nodes have labels and a pair of nodes may be connected by an edge with one or more labels. For example, in an airline route database, ‘large European city’ may be the label on the Paris node and ‘large Asian city’ may be the label on the New Delhi node and the edge between the two cities may be labelled by several carriers. This article presents an analytical method to compute the p-values of labelled subgraph (sub-network) motifs in such labelled multi-relational networks (multigraphs). The method (and a fast approximation to the method) works for both directed and undirected graphs and extends to large subgraphs. We have validated these methods on a dataset of medium size real networks (up to tens of thousands of nodes and hundreds of thousands of edges) of different types (biological, infrastructural and collaboration networks). The pure analytical model is faster than a randomized simulation model by a factor of approximately 1000 in most of our experiments. This improvement in performance is greater for larger graphs. The approximate analytical model avoids the calculations of statistical variance and achieves nearly the same precision and recall as the pure analytical model while being several times faster. To test the scalability of our methods, we run our algorithms on synthetic and real datasets from protein–protein interaction networks, airline flight paths, the internet infrastructural network and the IMDB movie network. We also illustrate a use case of this form of analysis on a large relationship network of people involved in the Panama papers scandal, retrieving frequently used money laundering patterns. labelled multigraphs motif enumeration; motif statistical significance; random network models; multi-relational networks; multigraphs.