bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interaction of thyroid hormone with brown adipose tissue
Authors: Hankir M. , Krause K. , Tönjes A. , Fenske W. K. , Sabri O. , Hesse S. , Steinhoff K. G. 
Published: October 2018

SummaryBrown adipose tissue (BAT) plays an important role in regulating core-body temperature in various species including man. [18F]FDGPET/ CT imaging first revealed the presence of metabolically active BAT depots and that decreased BAT function is associated with various metabolic conditions. Thyroid hormone (TH) in concert with sympathetic nervous system signalling (SNS) stimulates BAT thermogenesis and thyroid disorders result in dysfunctional BAT. Currently, research is focussing not only on BAT regulation but also on browning of white adipose tissue (WAT) to BAT beige adipose tissue (BeAT) in order to develop novel treatments for human obesity and related conditions. While [18F]FDG-PET/ CT imaging is continuing to provide valuable insights into BAT and BeAT function in health and disease, there is a pressing need to develop alternative radiotracers that reliably track their activity in vivo. As a result it is expected that preclinical micro PET/CT investigations of BAT and BeAT will gain in prominence.The aim of this short review is to i) describe fundamentals in BAT biology, ii) highlight some of the clinical and preclinical studies performed on humans and rodents with a focus on TH, BAT and PET/CT, and iii) bridge these data with our own studies within the DFG thyroid transact priority program.
Is thyroid surgery performed too often in Germany?
Authors: Verburg F. A. 
Published: October 2018

SummaryThyroid surgery is one of the more common surgical procedures in Germany. This is in contrast with the situation in some other countries, where this procedure is performed comparatively rarely. In this paper the number of thyroid surgeries in Germany is compared with other western countries (Netherlands, USA, England). In contrast to e. g. the USA and England the number of thyroid surgeries in Germany is declining, however with approximately 109/100 000/year in 2012 is still elevated (Netherlands: 16/100 000/year, USA: at least 42/100 000/year, England: at least 27/100 000/year).Possible contributing factors to this higher number of thyroid surgeries in Germany are explored. These factors include iodine deficiency, the frequent use of advanced diagnostics such as ultrasound, insufficient use of preoperative diagnostic measures such as fine needle biopsy and the practice of “defensive medicine”. How much each of these factors contributes is however unclear.
Combined coagulation factor VIII and factor IX deficiency (CDF8F9) in a patient from Lithuania
Authors: Pezeshkpoor B. , Biswas A. , Goldmann G. , Horneff S. , Gimbutyte M. , Malciute L. , Jurgutis R. , Oldenburg J. , Ivaškevičius V. 
Published: October 2018

SummaryHaemophilia A (FVIII deficiency) and haemophilia B (FIX deficiency) are X-linked inherited bleeding disorders. It is a very rare event to identify both haemophilias in the same patient. So far, only two families with such combination are reported in the literature worldwide supported by genetic background. Patients and methods: Evaluation of clinical data, determination of FVIII and FIX levels and genetic analysis of F8 and F9 genes by direct sequencing. Results: We report on a patient having severe haemophilia B (FIX:C <1 IU dl-1) and mild haemophilia A (FVIII:C 18 IU dl-1 ). FIX deficiency was known since childhood, whereas mild haemophilia A was confirmed at the age of 42 due to unexpected bleeding complications after dental extraction despite adequate substitution with plasma derived FIX concentrate. F9 gene analysis showed a point mutation in exon 2 (c.223C>T, p.R75X), whereas F8 gene analysis revealed a point mutation in exon 4 (c.545A>C, p.D182A). The mother of the patient was heterozygous for F8 mutation, but not for F9 mutation suggesting a de novo F9 mutation. Accidentally, further family from Germany with mild Haemophilia A was identified to have the same F8 mutation. F8 Haplo-type analysis revealed that the p.D182A mutation most likely represents a founder mutation with common ancestors of the German and the Lithuanian family. Conclusions: Our results confirm the rare event of Haemophilia A and haemophilia B in the same patient originating from two distinct genetic defects in F8 and F9 genes.
A novel missense mutation in the FGB gene (p.Gly302Arg) leading to afibrinogenemia
Authors: Rühl H. , Detarsio G. , Biswas A. , Gupta S. , Davoli M. , Quartara A. , Pérez S. , Raviola M. , Oldenburg J. , Ivaškevičius V. 
Published: October 2018

SummaryAfibrinogenemia represents the rarest form of fibrinogen deficiency. Causative missense mutations occur rarely and may improve the understanding of fibrinogen structure and function. Patients and methods: The propositus was a 26-year-old Argentinian with afibrinogenemia. FGA, FGB and FGG exons and flanking regions were screened by sequencing and the mutant protein was analyzed in silico. Results: A novel missense mutation in the FGB gene (Bbeta Gly272Arg, p.Gly302Arg) was identified. In silico analysis revealed its location in a highly conserved region, which preserves the core fold of the C-terminal beta-chain and is important for proper secretion. A substitution by a positively charged large Arg residue in this area would most likely disturb the core fold by additional interactions with adjacent residues (p.Asp291, p.Asp297, p.Asp311), or by forming of non-native interactions with other proteins, thereby hindering the action of molecular chaperones. Both alternatives would disturb the regular secretion of the beta-chain. Conclusions: The novel mis-sense mutation in the FGB gene causes afibrinogenemia most probably by affecting the secretion of the fibrinogen beta-chain.
Interest in Health Information Exchange in Ambulatory Care: A Statewide Survey
Authors: Ross S. E. , Mellis B. K. , Beaty B. L. , Schilling L. M. , Davidson A. J. , Tham E. 
Published: October 2018

SummaryObjective: Assess the interest in and preferences of ambulatory practitioners in HIE.Background: Health information exchange (HIE) may improve the quality and efficiency of care. Identifying the value proposition for smaller ambulatory practices may help those practices engage in HIE.Methods: Survey of primary care and specialist practitioners in the State of Colorado.Results: Clinical data were commonly (always [2%], often [29%] or sometimes [49%]) missing during clinic visits. Of 12 data types proposed as available through HIE, ten were considered “extremely useful” by most practitioners. “Clinical notes/consultation reports,” “diagnosis or problem lists,” and “hospital discharge summaries” were considered the three most useful data types. Interest in EKG reports, diagnosis/problem lists, childhood immunizations, and discharge summaries differed among ambulatory practitioner groups (primary care, obstetrics-gynecology, and internal medicine subspecialties).Conclusion: Practitioners express strong interest in most of the data types, but opinions differed by specialties on what types were most important. All providers felt that a system that provided all data types would be useful. These results support the potential benefit of HIE in ambulatory practices.
Ambivalenz des Fortschritts – Ist weniger mehr?
Authors: Scharf R.E. 
Published: October 2018

ZusammenfassungDie Ökonomisierung des Gesundheitssystems hat zu einem industrialisierten Medizinbetrieb geführt. Die Auswirkungen und Folgen sind beträchtlich und begünstigen eher eine weitere Kostenexplosion infolge auferlegter Zwänge zur Erhöhung von Fallzahlen und zur Effizienzsteigerung. Hier sind kritische Positionsbestimmung und Richtungswechsel gefragt. Mögliche Auswege aus der derzeitigen Krise werden erörtert.
7th International Congress of the Croatian Society of Nuclear Medicine
Authors: Težak S , Huic D , Poropat M , Kasal B , Schicha H , Dodig D 
Published: October 2018

SummaryThe Seventh International Congress of The Croatian Society of Nuclear Medicine gives an overview of present-day nuclear medicine. For the Congress 82 papers were selected: 50 for oral and 32 for poster presentation. Of 82 accepted papers 44 came from Croatia. Other papers came from Austria, Bosnia and Herzegovina, Germany, Greece, Hungary, Italy, Kosovo, Russia, Slovenia and Serbia. There were 16 lectures as part of CME programme. The congress shows that Croatian nuclear medicine follows general trends of the European nuclear medicine. This report includes a selection of abstracts that might interest the readers of Nuklearmedizin.
Versorgung von Menschen mit chronischen Wunden im Pflegeheim
Authors: Hampel-Kalthoff C. 
Published: October 2018

ZusammenfassungAls Setting bietet das Pflegeheim für eine hochwertige Versorgung von Menschen mit chronischen Wunden im Grunde ein förderliches Umfeld. Betreuungsdichte, Voraussetzungen für hygienische Verbandswechsel und Ansatzpunkte für interprofessionelle Kommunikation und Zusammenarbeit bieten gute Voraussetzungen. Gleichzeitig ist das Setting Pflegeheim gekennzeichnet von besonderen Herausforderungen: Häufige Multimorbidität und vor allem Demenzerkrankungen unter den Bewohnern, aber auch fehlende spezielle Kompetenzen im Personal, vor allem aber häufig fehlende Konzepte in den Einrichtungen sind Gründe, warum bei Pflegevisiten oft Fehloder Unterversorgungen zu beobachten sind. Die im Alltag zu beobachtenden Strategien unter diesen Rahmenbedingungen bleiben meist Einzelaktionen. Hierzu zählt u.a. das Hinzuziehen von Homecare-Anbietern als Berater, die sich aber durch den Verkauf von Pflegeprodukten finanzieren müssen, und somit eher zur Fokussierung auf Materialien, insbesondere Verbandsmittel, beitragen als die Versorgungsstrukturen und -prozesse insgesamt zu betrachten. Zu den zu beobachtenden Strategien zählen auch Krankenhauseinweisungen oder Versuche von Mitarbeitern der Kostenträger externe Interventionen zu initiieren. In der Regel sind diese Strategien nur begrenzt erfolg-reich, weil sie Strukturen und Prozesse nicht beeinflussen, und weil sie Strategien individueller Akteure sind, jedoch nicht auf Konsens und Ko-operation aller Beteiligten basieren.Für eine Verbesserung der Versorgungsqualität bei Menschen mit chronischen Wunden im Pflegeheim sind aber hausinterne und interprofessionelle Konzepte erforderlich, die den Blick auf die Strukturen und Prozesse, auf Qualifikationen, Verantwortlichkeiten und Abläufe richten. Diese Konzepte sollten von Heimleitungen, Pflegefachkräften im Haus, Ärzten und externen pflegerischen Fachexperten für die Versorgung von Menschen gemeinsam entwickelt und umgesetzt werden. Die Konzepte sollten inhaltlich Qualifikationen, Zuständigkeiten und einheitliche Abläufe vorsehen und bei Bedarf die vertragliche geregelte Hinzuziehung eines unabhängigen pflegerischen Fachexperten ermöglichen, der die Pflegefachkräfte im Hause unterstützen kann.
Discussion of “Generalized Estimating Equations: Notes on the Choice of the Working Correlation Matrix”
Authors: Breitung J. , Chaganty N. R. , Daniel R. M. , Kenward M. G. , Lechner M. , Martus P. , Sabo R. T. , Wang Y.-G. , Zorn C. 
Published: October 2018

Summary
Objective: To discuss generalized estimating equations as an extension of generalized linear models by commenting on the paper of Ziegler and Vens “Generalized Estimating Equations: Notes on the Choice of the Working Correlation Matrix”.
Methods: Inviting an international group of experts to comment on this paper.
Results: Several perspectives have been taken by the discussants. Econometricians have established parallels to the generalized method of moments (GMM). Statisticians discussed model assumptions and the aspect of missing data. Applied statisticians commented on practical aspects in data analysis.
Conclusions: In general, careful modeling correlation is encouraged when considering estimation efficiency and other implications, and a comparison of choosing instruments in GMM and generalized estimating equations (GEE) would be worthwhile. Some theoretical drawbacks of GEE need to be further addressed and require careful analysis of data. This particularly applies to the situation when data are missing at random.
Health IT in Asia-Pacific Region
Authors: Kimura M. 
Published: October 2018

SummaryAPAMI 2009 was held in Hiroshima, Japan, on November 22–24, 2009. This issue includes two selected papers recommended by the programming committee co-chairs. They are “Lessons Learned from Data Mining of WHO Mortality Database” and “Survey on Medical Records and EHR in Asia-Pacific Region – Languages, Purposes, IDs and Regulations”. The theme of APAMI 2009 was "What are the medical records for?" A Hiroshima episode; Medical Records at Dr. Ban’s Clinic, 9 km from the Epicenter of A-Bomb, is included, which lets us think of the fundamental purpose of medical records.
On the Methodology and Scientific Fundamentals of Organizing, Representing and Analysing Data, Information and Knowledge in Biomedicine and Health Care
Authors: Haux Haux 
Published: October 2018

SummaryThis issue of Methods of Information in Medicine celebrates the journal‘s first 50 years. As the oldest journal in biomedical and health informatics and, being broader in its scope, as the journal dealing with the methodology and scientific fundamentals of organizing, representing and analysing data, information and knowledge in biomedicine and health care, the journal publications during the last five decades also reflect the formation of a scientific field that deals with information in biomedicine and health care. Five papers that arose from a scientific symposium on “biomedical informatics: confluence of multiple disciplines” held in Heidelberg, Germany, in June 2011 are included in this volume. The papers reflect not only the broad interdisciplinary scope of the journal, but also the broad and evolving scope of the field itself. We can also recognise that there is an ongoing need for original and relevant research. As a discipline that has an impact on many other fields and is also influenced by them, scientific exchange and collaborative research continues to be needed.
The Student Editorial Board of Methods of Information in Medicine
Authors: Haux R. , Leong T. Y. , McCray A. , Aronsky D. 
Published: October 2018

Summary

Objective
: Peer review is a critical process in the publication of scientific findings; trainees and young investigators, however, have few opportunities to learn systematically how to review manuscripts. Journal editors have an opportunity to engage trainees and young investigators in the peer review process early during their career.

Methods
: Methods of Information in Medicine, an official journal of the International Medical Informatics Association, is initiating a Student Editorial Board. The journal invites applications from international graduate and post-doctoral training programs that have a focus on health informatics, biomedical informatics, or a related field.

Results
: Each year up to six trainees will be invited to join the Student Editorial Board. The trainees will go through a mentored training experience that includes an active involvement in the various aspects of peer review during their one to two-year term of appointment.

Conclusions
: The journal expects that the Student Editorial Board will benefit trainees and young investigators in becoming skilled reviewers and engaged peers who can offer professional, constructive, and informative feedback and enhance the process of scientific communication.
A Pen-based Interface for Generating Graphical Reports of Findings in Cardiac Catheterization
Authors: Igarashi T. , Haraguchi R. , Nakazawa K. , Mori Y. 
Published: October 2018

Summary

Objectives
: This paper introduces a pen-based interface for the graphical reporting of findings in cardiac catheterization.

Methods
: The user can interactively draw, erase, move, and deform coronary arteries as well as record stenoses on them. The location and degree of each stenosis is represented visually and the doctor can record various treatments such as bypasses and stents on the diagram. In addition, the system automatically extracts semantic information from the graphical representation and stores it in XML format. The system can also generate a table in the format specified by the American Heart Association.

Results
: Our current implementation is a research prototype and is not yet being used in clinical practice. However, we have already demonstrated it to medical professionals and confirmed the following benefits.

Conclusions
: This system is useful not only as a tool for efficiently generating reports of findings but also as an effective explanation tool for patients.
Document Recognition and XML Generation of Tabular Form Discharge Summaries for Analogous Case Search System
Authors: Sumida T. , Yamamoto K. , Shinogi T. , Tsuruoka S. , Kawanaka H. 
Published: October 2018

Summary

Objectives
: This paper discusses and develops a document image recognition, keyword extraction and automatic XML generation system to search analogous cases from paper-based documents. In this paper, we propose the document structure recognition method and automatic XML generation method for the tabular form discharge summary documents. This paper also develops the prototype system using the proposed method. Evaluation experiments using actual documents are doneto discuss the effectiveness of the developed system.

Methods
: The developed system consists of the following methods. Paper-based summary documents are scanned by a scanner using 300 dpi first. Noise and tilt of the image are reduced by pre-processing, and the table structures are identified. Characters in the table are recognized and converted to text data by the OCR engine. XML documents are automatically generated using obtained results.

Results
: In this paper, patient discharge summary documents archived at Mie University Hospital were used. The results show that XML documents can be automatically generated when standard tabular form documents are input into the developed system. In this experiment, it takes about 20 seconds to generate an XML document using the general personal computer. This paper also compares the developed system with a commercial product to discuss the effectiveness of the present system. Experimental results also show that the accuracy of table structure recognition is high and it can be used in a practical situation.

Conclusions
: This paper showed the effectiveness of the proposed method to recognize the tabular form document images to generate XML documents.
Development of a Broadband Telemedical Network Based on Internet Protocol in the Asia-Pacific Region
Authors: Shimizu S. , Okamura K. , Hahm J. S. , Kim Y. W. , Han H. S. , Torata N. , Antoku Y. , Lee Y. S. , Tanaka M. , Nakashima N. 
Published: October 2018

Summary

Objectives
: To promote the exchange of knowledge and standardization of medical procedures and medical systems in the Asia-Pacific region, we established a medical networkwith high-quality moving images over broadband Internet lines in February 2003.

Methods
: Real-time teleconferences and live demonstrations with medical-qualityvideos, broadcastvia the Digital Video Transport System, have been used t teach surgical techniques and other medical procedures across national borders.The Asia-Pacific Advanced Network (APAN) committee in August 2005 formally approved our proposal to establish a medical working group within APAN. The networkwas expanded by the launch of the Trans- Eurasia Information Network 2 in 2006. By the end of 2006, we had conducted 82 events, in 10 countries in the Asia-Pacific region. The multi-station event has increased everyyear.

Results
: There have been no serious transmission problems or ethical conflicts so far. With these experiences and current achievements, we hope to extend this advanced network system to the entire Asia-Pacific.

Conclusion
: This system is a promising and very useful tool for the standardization of medical system and procedures across national borders. Drawing upon these experiences and current achievements, we hope to extend this advanced network system to the entire Asia- Pacific region.
Einflussfaktoren auf die Kalziumkonzentration im Erstkolostrum bei Holstein-Friesian-Kühen und deren Beziehung zur postpartalen Kalziumkonzentration im Blut
Authors: Staufenbiel Rudolf , Karl Maria 
Published: October 2018

Zusammenfassung
Ziel: Untersuchung von Einflussfaktoren auf die Kalziumkonzentration im Erstkolostrum mit Prüfung folgender Hypothesen: Die Laktationszahl ist der entscheidende Einflussfaktor auf die Kalziumkonzentration und es besteht ein Zusammenhang zur postpartalen Blutkalziumkonzentration. Material und Methoden: Von April 2012 bis März 2013 erfolgte eine Beobachtungsstudie auf einem kommerziellen Milchviehbetrieb (2278 Holstein-Friesian-Kühe) mit Analyse folgender Variablen: Menge und Kalziumkonzentration des Kolostrums; Blutserumkonzentrationen von Kalzium, Phosphor, freien Fettsäuren (NEFA) und β-Hydroxybutyrat (BHB); Rückenfettdicke; Milchleistung; Daten zur Kalbung; Laktationszahl; Kuhvater; Trächtigkeitsdauer; Erstkalbealter; Trockenstehdauer; Fruchtbarkeitskennzahlen der Vorlaktation sowie Erkrankungen in der Trockenstehphase und bis 3 Tage post partum. Die Daten wurden mithilfe der Varianzanalyse, Korrelationsanalyse sowie der multiplen linearen Regressionsanalyse auf Zusammenhänge und Einflussfaktoren stufenweise ausgewertet. Ergebnisse: Die mittlere Kalziumkonzentration betrug 2386 mg/l (Standardabweichung = 550 mg/l), wobei der Wert bei Färsen 148,5 mg/l höher lag als bei Kühen. Als relevante Einflussfaktoren ergaben sich die mittlere Tagesmilchmenge der ersten Laktationswoche und die Rückenfettdicke zum Zeitpunkt des Trockenstellens. Der Zusammenhang zur Milchmenge war negativ, was für einen Verdünnungseffekt spricht. Eine Zunahme der Rückenfettdicke bewirkte eine Erhöhung der Kalziumkonzentration im Kolostrum. Zusammen erklärten beide Faktoren 25% der Variabilität der Kolostrumkal ziumkonzentration. Laktationszahl und Kalziumkonzentration im Blut waren keine signifikanten Einflussfaktoren. Schlussfolgerung und klinische Relevanz: Die Hypothesen wurden widerlegt. Es gibt keinen Zusammenhang zur peripartalen Serumkalziumkonzentration und die Laktationszahl ist kein relevanter Einflussfaktor. Die Kalziumkonzentration im Kolostrum hat eine große individuelle Spannweite. Eine Beeinflussung über die Milchmengeneinsatzleistung und die Rückenfettdicke ist möglich, aber im Hinblick auf die Gebärpareseprophylaxe ohne Relevanz.