bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Cinnamic Acid Derivatives as Potential PPARδ Agonists for Metabolic Syndrome: Design, Synthesis, Evaluation and Docking Studies
Authors: Chauhan Ajay , Grewal Ajmer S. , Pandita Deepti , Lather Viney 
Published: March 2019

Background:Peroxisome proliferator-activated receptor (PPAR) δ is expressed universally in the entire tissues, particularly in those concerned with the lipid metabolism. PPAR δ stimulation alters body’s energy fuel preference to fat from glucose and shows up as an emerging pharmacological target for the treatment of metabolic disorders.Methods:A new series of cinnamic acid derivatives was synthesized and evaluated for the antidiabetic and antiinflammatory activities in the animal models followed by in silico docking studies to determine the binding interactions for the best fit conformations in the binding site of the PPARδ protein.Results:Amongst the synthesized molecules, compound 3 showed higher antidiabetic activity in oral glucose tolerance test and compound 1 showed higher antiinflammatory activity in the carrageenan induced rat paw oedema method. The in vivo study results were supported by the similar in silico molecular docking results. Most of the synthesized derivatives showed drug likeness as depicted via Lipinski’s rule of 5.Conclusion:These molecules can serve as the early hit molecules for the discovery of safe, effective and bioavailable PPARδ agonists for the potential treatment of various metabolic disorders.</P>
HPLC-DAD-Q-TOF/MS-Based Screening and Analysis of the Multiple Absorbed Bioactive Components in Rat Serum after Oral Administration of Xiexin Tang
Authors: Wang Xiaoyu , Li Shujiao , Wang Yuqing , Hu Rui 
Published: March 2019

Background:
Xiexin Tang (XXT) is a classic Traditional Chinese Medicine (TCM) formula
that has been used in herbal clinics for more than 1800 years. Recently, many studies have investigated
the pharmacological effects and chemical composition of XXT. However, there is little information
about systematic studies on the material basis of its efficacy. In the present study, the serum pharmacochemistry
technique and HPLC-DAD-Q-TOF/MS were performed to screen and analyze the multiple
absorbed bioactive components and metabolites of orally dosed XXT in rat serum.

Methods:
Bio-samples and herbal extracts were analyzed and detected by HPLC-DAD-Q-TOF/MS.
Upon comparison of the chromatograms of the single-constituent decoctions with that of the XXT formulation,
the peak quantity and peak intensity of the formulated decoction showed some variation from
those of the single-constituent decoctions.

Results:
Twenty-one serum-adsorbed constituents were identified after intragastric administration of
herbal extracts, of which 8 originated from Rhei Radix et Rhizoma (RRR), 5 from Coptidis Rhizoma
(CR), and 8 from Scutellariae Radix (SR). The results showed that the main adsorbed constituents in the
serum were anthraquinones, anthrones, chromones, and butyrophenones, alkaloids, and flavonoids.

Conclusion:
The results demonstrate that an effective and reliable analytical method is set up for
screening the bioactive components of Chinese herbal medicine, which provided a meaningful basis for
further pharmacology and active mechanism research of XXT.
Targeting Epidermal Growth Factor Receptor in Non-Small-Cell-Lung Cancer: Current State and Future Perspective
Authors: Bao Shui-Ming , Hu Qing-Hui , Yang Wen-Ting , Wang Yao , Tong Yin-Ping , Bao Wen-Dai 
Published: March 2019

Background:
Lung cancer is one of the leading cause of cancer death worldwide, the most common
histological type of lung cancer is non-small cell lung cancer (NSCLC), whose occurrence and development is
closely related to the mutation and amplification of epidermal growth factor receptors (EGFR). Currently , a
series of targeted drugs were developed on the inhibition of EGFR such as epidermal growth factor receptortyrosine
kinase inhibitor EGFR-TKI and monoclonal antibody (McAb).

Objective:
We sought to summarizes the current drugs targeting Epidermal Growth Factor Receptor in nonsmall-
cell-lung.

Methods:
We conducted a comprehensive review of the development and application of EGFR-TKI and McAb
which targeted EGFR in NSCLC and compared the mechanisms of PROTAC with the traditional inhibitors.
Results: The drugs targeted EGFR in NSCLC have been widely used in clinic practices. Compared to traditional
chemotherapy, these drugs excel with their clear and specific targeting, better curative effects, and less toxic and
side effects. However, the mechanism comes with some insurmountable weaknesses like serious toxic and other
side effects, as well as proneness to producing drug resistance.

Results:
The drugs targeted EGFR in NSCLC have been widely used in clinic practices. Compared to traditional
chemotherapy, these drugs excel with their clear and specific targeting, better curative effects, and less toxic and
side effects. However, the mechanism comes with some insurmountable weaknesses like serious toxic and other
side effects, as well as proneness to producing drug resistance.

Conclusion:
The emerging PROTAC (Proteolysis Targeting Chimera) technology has been successfully applied
to selective degradation of multiple protein targets, including EGFR. It also highlights the potential and challenges
of PROTAC therapy regarding future combination therapeutic options in NSCLC treatment.
“Whey Aye My Good Sir”: Has Cheryl Fernandez-Versini’s Accent Moved from Tyneside English to RP?
Authors: Wallace Victoria 
Published: March 2019

This article analyses the speech of Cheryl Fernandez-Versini (nee Tweedy, formerly Cole), henceforth “Cheryl” , who experienced rapid geographical and socioeconomic mobility between 2002 and 2014. In 2002, Cheryl was a working-class 19-year-old from Newcastle Upon Tyne, north-east England. Since then, she has risen to fame on the talent show Popstars: The Rivals , in the girl band Girls Aloud , through her marriage to footballer Ashley Cole, and through her work as a judge on The X Factor , among other things. This paper seeks to analyse the effect this has had on her accent.Four recordings between 2002 and the present day are analysed to discuss changes to her original Tyneside English (TE) accent, specifically through the changing phonetics of the FACE and the GOAT vowels. These changes are discussed in terms of both the TE speech community and Cheryl’s personal experiences. The two vowels have traditional diphthongs in TE which are different from the diphthongs in Received Pronunciation (RP). However, these vowels have been found to be undergoing dialect levelling, with many TE speakers producing them as the monophthongs found in the rest of the North (Watt 2000, 2002). The paper therefore investigates whether Cheryl follows the pattern of other TE speakers or moves towards RP.The recordings used are taken from online videos of interviews. The first time point studied is 2002, when Cheryl first rose to fame through Popstars: The Rivals , in which her GOAT and FACE vowels are shown to be the Northern monophthongs which have resulted from dialect levelling in TE. The intermediate time points studied are 2006 and 2011. In 2006, Cheryl was engaged to Ashley Cole and had been living and working in the south of England for 4 years. Both vowels move closer to RP in position but remain monophthongal. The 2011 recording is an interview in the US, during Cheryl’s brief career on American X Factor. The data for this time point are particularly interesting as the position of the vowels varies more, and the average position of both vowels does not fit the pattern of change, indicating style-shifting. The 2014 recording was the most recent interview of substantial length which could be found at the time of data collection. The analysis shows that Cheryl’s GOAT vowel is significantly closer to RP than it was in 2002, despite remaining a monophthong, while her FACE vowel appears to have become a diphthong as in RP.The results show that Cheryl does undergo lifespan change in these two vowels, being closer to RP at the time of writing than in 2002. However, the two intermediate time points studied show that these vowels do not change in parallel, as predicted by Watt (2000). The intermediate time points, in particular the 2011 data, give support to the conclusions of Rickford and Price (2013) and Bowie (2009) that in order to fully understand data on lifespan change, intermediate time points and factors other than age must be taken into account.
A conceptualização de papel: uma revisão teórica (The conceptualization of role: a theoretical review)
Authors: Pacheco Roberta Fernandes 
Published: March 2019

A partir das considerações de papel de Goffman ([1959] 2005) e a releitura feita por Weizman (2006, 2008) e Sarangi (2010, 2011) em uma perspectiva interacional em cenários profissionais, este artigo busca discutir acerca da noção de papel, buscando propor um construto teórico-analítico passível de utilização em futuras pesquisas.PALAVRAS-CHAVE: Papel; Discussão teórica; Construto teórico-analítico.
PENGGUNAAN MODEL PEMBELAJARAN PROBLEM BASED LEARNING BERBANTU MEDIA KONKRIT DALAM UPAYA PENINGKATAN PROSES DAN HASIL BELAJAR MUATAN IPA TEMA7 SUBTEMA 1 KELAS 4
Authors: Buda Chinda Hibatul 
Published: March 2019

ABSTRACTThe research was carried out in order to improve the processes and outcomes of learning with media concrete on the charge on IPA Theme 7 subtema 1. The research was carried out on May 7-May 16, 2018 at 4th grade Student Affairs Tegalrejo 01 school year 2017/2018. This type of research using research action class. The percentage of observations of teachers has increased from 53% to cycle pre 72.5% in cycle I and 85.5% in cycle II. Students experience increased activity of pre cycle 51.67% to 71.66% in cycle I and 86.5% in cycle II. Student learning outcomes on pre cycle amounted to 11 students with a percentage of 40.74%, and not completely 16 students with percentages of 59.26%. After doing a repair on the cycle I increase that is 19 students complete with a percentage of 70.37% and 8 students not finished with a percentage of 29.63%, the result of the repair cycle I have yet to achieve the attainment of indicators i.e. 80% ketuntasan, then in to perform a repair cycle II. After the execution of the cycle II an increase in 23 students finished with a percentage of 85.19% whereas students who do not complete amounted to 14.81 percentage people with 4%. Thus improvements with the Model of Problem Based Learning with concrete media can say successful because the results of learning objectives i.e. the percentage of 80%.Keyword: Problem Based Learning, Concrete Media, processes and Outcomes of learning, science
PENERAPAN METODE PEMBELAJARAN KOOPERATIF BERBANTUAN MEDIA GAME PUZZLE UNTUK MENINGKATKAN MOTIVASI BELAJAR DAN PEMAHAMAN BELAJAR SISWA PADA MATA PELAJARAN KANTOR DEPAN (RESERVASI)
Authors: Suardani Luh 
Published: March 2019

Tujuan dari diadakannya penelitian ini adalah untuk mengetahui peningkatan motivasi belajar dan pemahaman belajar siswa pada mata pelajaran kantor depan (reservasi) Kelas XI AP4 SMK Negeri 2 Singaraja semester ganjil tahun pelajaran 2016/2017 setelah diterapkannya metode pembelajaran kooperatif berbantuan media game puzzle. Penelitian ini adalah penelitian tindakan kelas (PTK). Subjek dalam penelitian tindakan kelas ini adalah siswa kelas XI AP 4 SMK Negeri 2 Singaraja dengan jumlah siswa 40 orang terdiri dari 17 orang siswa laki-laki dan 23 orang siswa perempuan. Sedangkan objeknya adalah motivasi belajar dan pemahaman belajar siswa. Data motivasi belajar siswa dikumpulkan dengan angket/kuesioner, sedangkan data pemahaman belajar siswa dikumpulkan dengan tes. Analisis data yang digunakan pada penelitian ini menggunakan analisis data deskriptif. Berdasarkan analisis data yang dilakukan dapat disimpulkan bahwa penerapan metode pembelajaran kooperatif berbantuan media game puzzle dapat meningkatkan motivasi belajar dan pemahaman belajar siswa pada mata pelajaran kantor depan (reservasi) kelas XI AP4 SMK Negeri 2 Singaraja semester ganjil tahun pelajaran 2016/2017. Kata kunci: metode pembelajaran kooperatif, media game puzzle, motivasi belajar, pemahaman belajar siswa
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE TAI (TEAM ASSISTED INDIVIDUALIZATION) UNTUK MENINGKATKAN AKTIVITAS DAN PRESTASI BELAJAR PADA MATA PELAJARAN TATA GRAHA
Authors: Sutiari Ni Luh 
Published: March 2019

Tujuan dari diadakannya penelitian ini adalah untuk meningkatkan aktivitas dan prestasi belajar siswa pada mata pelajaran tata graha melalui model pembelajaran kooperatif tipe TAI (Team Assisted Individualization) di kelas XI Akomodasi Perhotelan 1 SMK Negeri 2 Singaraja. Penelitian ini adalah penelitian tindakan kelas dengan subjek siswa kelas XI Akomodasi Perhotelan 1 SMK Negeri 2 Singaraja. Sedangkan objeknya adalah aktivitas dan prestasi belajar siswa. Data aktivitas belajar siswa dikumpulkan dengan observasi, sedangkan data prestasi belajar siswa dikumpulkan dengan tes. Analisis data yang digunakan pada penelitian ini menggunakan analisis data deskriptif. Berdasarkan penelitian yang telah dilakukan, didapatkan hasil bahwa: 1) penerapan model pembelajaran kooperatif tipe TAI dapat meningkatkan aktivitas siswa dalam mata pelajaran tata graha pada siklus I diperoleh hasil rata-rata 40% meningkat menjadi 72% pada siklus II, dan 2) penerapan model pembelajaran kooperatif tipe TAI meningkatkan prestasi belajar siswa dalam mata pelajaran tata graha sesuai dengan hasil tes pada siklus I diperoleh rata-rata 75,80% meningkat menjadi 88% pada siklus II. Kata kunci: aktivitas belajar siswa, prestasi belajar, TAI (Team Assisted Individualization).
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE TGT (TEAMS GAMES TOURNAMENT) UNTUK MENINGKATKAN MOTIVASI DAN HASIL BELAJAR PESERTA DIDIK
Authors: A’yuningsih Dewi Qurrota , Suardana I Nyoman , Suwenten I Made 
Published: March 2019

Penelitian ini bertujuan untuk meningkatkan motivasi dan hasil belajar peserta didik kelas X MIA 2 SMAN 3 Singaraja Tahun Ajaran 2016/2017 melalui penerapan model pembelajaran kooperatif tipe TGT (Teams Games Tournament). Jenis penelitian ini adalah penelitian tindakan kelas. Pengukuran motivasi belajar peserta didik didasarkan pada hasil angket motivasi belajar peserta didik dan didukung oleh hasil lembar observasi motivasi peserta didik. Sedangkan pengukuran hasil belajar peserta didik didasarkan pada tes hasil belajar yang dilaksanakan setiap akhir siklus untuk mengetahui ada tidaknya peningkatan. Data yang diperoleh dalam penelitian ini dianalisis secara deskriptif kuantitatif. Hasil penelitian menujukkan bahwa Penerapan model pembelajaran kooperatif tipe TGT dalam pembelajaran kimia dapat meningkatkan motivasi dan hasil belajar peserta didik kelas X MIA 2 SMA Negeri 3 Singaraja Tahun Ajaran 2016/2017 dengan persentase rata-rata motivasi belajar dari pra penelitian hingga siklus 2, yaitu 51,15% menjadi 60,73% pada siklus 1 dan menjadi 76,5% pada siklus 2. Hasil tes belajar peserta didik juga mengalami peningkatan dari 32% pada siklus satu menjadi 84% pada siklus dua. Peningkatan motivasi dan hasil belajar peserta didik didukung dengan data persentase keseluruhan hasil angket respon peserta didik terhadap model pembelajarn kooperatif tipe TGT, yaitu sebanyak 85,52%. Penerapan model kooperatif tipe TGT dapat digunakan sebagai salah satu alternatif model pembelajaran bagi guru dalam proses pembelajaran. Namun, model pembelajaran ini membutuhkan waktu yang lebih banyak dalam proses pembelajarannya karena adanya permainan. Maka dari itu, guru dituntut untuk bisa membagi waktu dalam penyampaian materi yang sesuai dengan indikator pencapain kompetensi.
Identifying New Knowledge Areas to Strengthen the Project Management Institute (PMI) Framework
Authors: Iyer K. Chandrashekhar , Banerjee Partha S. 
Published: March 2019

Abstract
In an increasingly volatile, uncertain, complex and ambiguous (VUCA) world, managers of capital projects are under relentless pressure to consistently meet their performance expectations. At the execution stage, managers have to constantly orchestrate competing demands on scare resources and, simultaneously, manage project operations to meet time, costs and quality compliances. This calls for simple methods to distinguish factors that could cause execution stage delays and prioritise their remedial actions. The objective, therefore, was to propose and test a methodology through empirical evidence, which could be useful for managers to focus on the distinguishing factors (rather than on all factors) to achieve execution excellence. We used a three-stage methodology leveraging the existing Project Management Institute (PMI) framework to define variables and then tested the methodology using case data generated from projects adopting a grounded theory approach. A set-theoretic, multi-value qualitative comparative analysis (QCA) tool helped appropriately configure this empirical case data and a subsequent Boolean minimisation technique then identified the distinguishing factor(s) that explained superior project schedule performance. The results corroborated literature findings. Two contributions emerged from this study: (a) our methodology enabled a richer analysis of the case than what would have been possible by adopting a more conventional approach; and (b) there is a potential for a domain-specific extension of the PMI framework to cover technology transfer projects having their unique knowledge areas.
Evaluación de algoritmos basados en lógica difusa para el procesamiento de señales de registro de pozo abierto.
Authors: Pérez Carlos Alberto , Camargo Jorge Arturo , Andrade Trujillo Andrés Guillermo , Polanco Toledo Juan Manuel 
Published: March 2019

Hoy en día es muy común el uso de técnicas computacionales inteligentes para la solución de problemas de caracterización, reconocimiento de patrones y toma de decisiones. Con la interpretación de perfiles se busca conocer las propiedades de la roca y fluidos para encontrar posibles zonas de hidrocarburos en las formaciones geológicas del subsuelo, mediante el uso de sistemas de información y conocimiento como bases de datos, sistemas expertos, dentro de los cuales la lógica difusa presenta un conjunto de herramientas que facilitan el alcance de sus objetivos.
En este documento se presenta la implementación y evaluación de algoritmos basados en lógica difusa aplicados al sistema de información y conocimiento de perfiles de pozos, para llevar a cabo la caracterización e identificación de zonas de interés (zonas que contienen hidrocarburos), procesando datos de perfiles de pozo abierto. El producto final es un archivo desarrollado en el entorno de Matlab®, donde se cargan los datos de perfiles de Rayos Gamma, Porosidad, Resistividad y Potencial espontáneo, y con base en el valor de los anteriores parámetros, se obtienen las zonas de interés de cada pozo.
La Universidad virtual una metodología para su desarrollo
Authors: Motta Manrique Jesus Antonio 
Published: March 2019

La Universidad virtual es la Universidad del futuro, para cualquiera en cualquier parte. La Universidad Virtual (UV), es aquella que existe en el ciberespacio de Internet. Es una universidad global accesible a cualquiera en cualquier parte y en cualquier tiempo. Está muy relacionada con el desarrollo futuro de la tecnología. Sus egresados serán profesionales con habilidades y conocimientos que podrán trabajar en cualquier parte del mundo en una sociedad de la información que será el mejor lugar para su participación.
ACOFI, promueve el mejoramiento de la calidad de los pregrados universitarios de Ingeniería
Authors: Ramirez Plazas Hernando 
Published: March 2019

Con motivo de la expedición del Decreto Número 792 del 08 de mayo de 2001 , "por el cual se establecen estándares de calidad en programas académicos de pregrado en ingeniería" , consideramos conveniente consultar al Ingeniero Jaime Salazar Contreras sobre el acompañamiento que ACOFI puede prestar a las facultades de Ingeniería del país en la aplicación del mencionado Decreto, toda vez que el Gobierno Nacional contó con su activa participación y el aporte de las instituciones de educación superior en la definición del mismo.
Controvérsias no mundo da performance art: um relato de pesquisa
Authors: Martins Daniela Félix 
Published: March 2019

Fundamentado em pesquisa desenvolvida no doutorado, o texto tem por objetivo apresentar a arte da performance realizando-se e permanecendo no mundo através de um fluxo de interações entre artistas, públicos, produtores, políticas públicas, espaços tradicionais (galerias e museus) e não tradicionais de arte (ruas, espaços públicos em geral). Realização e permanência referindo-se à sustentação da performance numa duração como evento ao vivo e também aos modos em que ela continua operando, mediante seus registros em fotos, vídeo, instruções escritas, vestígios materiais etc. Esses elementos foram reunidos em trabalho de pesquisa empírica, principalmente no Brasil, mas em breves períodos no Chile e Peru, e posteriormente, em Londres, onde foi mais extenso o tempo dedicado ao trabalho de pesquisa, que em sua maior parte consistiu em pesquisa documental, na LADA – Live Art Development Agency.
Drama, performance e experiência
Authors: Cruz Danielle Maia 
Published: March 2019

Este artigo interpreta o desfile carnavalesco dos maracatus, na cidade de Fortaleza, a partir das noções de drama, performance e experiência formuladas por Victor Turner e Richard Schechner. Dentre as agremiações, tomará para análise especialmente o Nação Iracema. Parte-se do entendimento do Carnaval como drama social e drama estético, compreendendo a vida como espelho da arte, em que indivíduos, por meio de performancesmúltiplas, vivenciam experiências, dramatizam questões da vida social e evidenciam tensões em torno de elementos performáticos centrais no maracatu cearense. No plano teórico, o artigo visa contribuir no campo de estudos da performance e dos rituais, problematizando a oposição entre indivíduo e sociedade que marca a produção clássica no campo de análise dos rituais. Foca-se no modo como os performers do Nação Iracema se constituem enquanto sujeitos, apreendendo a relação dos mesmos com a audência e o amplo repertório cênico mobilizado para a apresentação carnavalesca.