bluuebunny/crossref_metadata_2025_split huggingface dataset:
The crystal-structure determination and redefinition of eztlite, Pb22+Fe33+(Te4+O3)3(SO4)O2Cl
Authors: Missen Owen P. , Mills Stuart J. , Spratt John , Welch Mark D. , Birch William D. , Rumsey Michael S. , Vylita Jan 
Published: May 2018

ABSTRACTThe crystal structure of eztlite has been determined using single-crystal synchrotron X-ray diffraction and supported using electron microprobe analysis and powder diffraction. Eztlite, a secondary tellurium mineral from the Moctezuma mine, Mexico, is monoclinic, space groupCm, witha= 11.466(2) Å,b= 19.775(4) Å,c= 10.497(2) Å, β = 102.62(3)° andV= 2322.6(9) Å3. The chemical formula of eztlite has been revised to${\rm Pb}_{\rm 2}^{2 +} {\rm Fe}_3^{3 +} $(Te4+O3)3(SO4)O2Cl from that stated previously as${\rm Fe}_6^{3 +} {\rm Pb}_{\rm 2}^{2 +} $(Te4+O3)3(Te6+O6)(OH)10·nH2O. This change has been accepted by the Commission on New Minerals, Nomenclature and Classification of the International Mineralogical Association, Proposal 18-A. Eztlite was reported originally to be a mixed-valence Te oxysalt; however the crystal structure, bond-valence analysis and charge balance considerations clearly show that all Te is tetravalent. Eztlite contains a unique combination of elements and is only the second Te oxysalt to contain both sulfate and chloride. The crystal structure of eztlite contains mitridatite-like layers, with a repeating triangular nonameric [${\rm Fe}_9^{3 +} $O36]45–arrangement formed by nine edge-sharing Fe3+O6octahedra, decorated by four trigonal pyramidal Te4+O3groups, compared to PO4or AsO4tetrahedra in mitridatite-type minerals. In eztlite, all four tellurite groups associated with one nonamer are orientated with the lone pair of the Te atoms pointing in the same direction, whereas in mitridatite the central tetrahedron is orientated in the opposite direction to the others. In mitridatite-type structures, interlayer connections are formed exclusivelyviaCa2+and water molecules, whereas the eztlite interlayer contains Pb2+, sulfate tetrahedra and Cl–. Interlayer connectivity in eztlite is achieved primarily by connectionsviathe long bonds of Pbφ8and Pbφ9groups to sulfate tetrahedra and to Cl–. Secondary connectivity isviaTe–O and Te–Cl bonds.
Cation distribution and valence in synthetic Al–Mn–O and Fe–Mn–O spinels under varying conditions
Authors: Stokes Thomas N. , Bromiley Geoffrey. D. , Gatta G. Diego , Rotiroti Nicola , Potts Nicola J. , Saunders Kate 
Published: May 2018

ABSTRACTThe spinel-group minerals, found in a range of igneous rocks, are resistant to weathering and can incorporate several multivalent elements, meaning they have the potential to provide insight into the redox conditions of parental magmas. Naturally occurring spinel can contain varying quantities of Mn, an element which occurs terrestrially and extra-terrestrially as Mn2+, Mn3+, Mn4+ and Mn5+. However, a lack of information on the effects of oxygen fugacity ($f_{{\rm O}_{\rm 2}}$) on: (1) Mn valence state and cation distribution; and (2) on spinel-melt partitioning means that the potential for a Mn-in-spinel oxy-barometer remains largely untested. Here, we use electron probe microanalysis, micro-focus X-ray Absorption Near Edge Structure (XANES) spectroscopy and single-crystal X-ray diffraction (SC-XRD) to investigate cation distribution and valence state in spinels in the Al–Mn–O and Fe–Mn–O systems synthesized at ambient pressure under varying $\hskip 2pt f_{{\rm O}_{\rm 2}}$ conditions. In contrast to previous studies, we find that the spectral resolution of the Mn K-edge XANES spectra is insufficient to provide quantitative data on Mn valence state and site occupancy, although it does verify that Mn is incorporated as both Mn2+ and Mn3+, distributed over tetrahedral and octahedral sites. Combination of data from XANES and SC-XRD refinements can, however, be used to model Mn, Al and Fe valence and site occupancy. It would be expected that Mn–Fe spinels have the potential to record $f_{{\rm O}_{\rm 2}}$ conditions in parental melts due to changes to the octahedral site under conditions that were more reducing. However, decoupling the effects of temperature and oxygen fugacity on the TFe3+–TMn2+ exchange in the Mn–Fe spinels remains challenging. In contrast, little variation is noted in Mn–Al spinels as a function of $\hskip 2pt f_{{\rm O}_{\rm 2}}$, implying that crystal chemistry and cation site geometry may significantly influence cation distribution, and by inference, crystal-melt partitioning, in spinel-group minerals.
Belousovite, KZn(SO4)Cl, a new sulfate mineral from the Tolbachik volcano with apophyllite sheet-topology.
Authors: Siidra Oleg I. , Nazarchuk Evgeny V. , Lukina Evgeniya A. , Zaitsev Anatoly N. , Shilovskikh Vladimir V. 
Published: May 2018

ABSTRACTBelousovite, ideally KZn(SO4)Cl, was found in a Yadovitaya fumarole of the Second scoria cone of the North Breach of the Great Tolbachik Fissure Eruption (1975–1976), Tolbachik volcano, Kamchatka Peninsula, Russia. Belousovite occurs as irregularly-shaped grains and in the form of microcrystalline masses associated with kamchatkite, langbeinite, euchlorine, anglesite and zincite. Belousovite is monoclinic,P21/c,a= 6.8904(5),b= 9.6115(7),c= 8.2144(6) Å, β = 96.582(2),V= 540.43(7) Å3andZ= 4 (from single-crystal diffraction data). The eight strongest lines of the powder X-ray diffraction pattern are [dmeasÅ(I)(hkl)]: 6.8451(100)(100), (3.6401)(71)($\bar{1}$21), (3.1592)(84)(1$\bar{1}$2), (3.1218)(41)($\bar{2}$11), (3.1140)(52)(022), (2.9812)(41)(031), (2.9121)(44)(130) and (2.0483)(19)($\bar{3}$12). The chemical composition determined by the electron-microprobe analysis is (wt.%): K2O 19.55, Rb2O 0.58, ZnO 34.85, SO334.65, Cl 14.77, –O = Cl23.34, total 101.06. The empirical formula based on O + Cl = 5 apfu is K0.97Rb0.01Zn1.00S1.01O4.03Cl0.97. The simplified formula is KZn(SO4)Cl. The crystal structure was solved by direct methods and refined toR1= 0.029 on the basis of 1965 independent observed reflections. The structure of belousovite consists of infinite [ZnSO4Cl]–layers and K+ions. [ZnSO4Cl]–layers are formed by corner sharing mixed-ligand ZnO3Cl tetrahedra and SO4tetrahedra. The topology of [ZnSO4Cl]–layers in belousovite is identical to [Si4O10]4–layers in the minerals of the apophyllite group. A review of mixed-ligand ZnOmClncoordination polyhedra in minerals and inorganic compounds is given.
Itelmenite, Na2CuMg2(SO4)4, a new anhydrous sulfate mineral from the Tolbachik volcano
Authors: Nazarchuk Evgeny V. , Siidra Oleg I. , Agakhanov Atali A. , Lukina Evgeniya A. , Avdontseva Evgeniya Y. , Karpov Gennady A. 
Published: May 2018

ABSTRACTItelmenite, ideally Na2CuMg2(SO4)4, was found in a fumarole of the Naboko scoria cone of the Tolbachik volcano Fissure Eruption (2012–2013), Kamchatka Peninsula, Russia. Itelmenite occurs as irregularly shaped grains as well as microcrystalline masses associated with anhydrite, saranchinaite, hermannjahnite, euchlorine, thénardite, aphthitalite and hematite. Itelmenite is orthorhombic, Pbca, a = 9.568(2) Å, b = 8.790(2) Å, c = 28.715(8) Å, V = 2415.0(11) Å3 and Z = 4 (from single-crystal diffraction data). The nine strongest lines of the powder X-ray diffraction pattern are [d(I)(hkl)]: 7.9614(41)(102), 7.1803(32)(004), 5.9122(64)(112), 3.8455(87)(122), 3.6292(52)(214), 3.3931(62)(215), 3.0003(44)(027), 2.9388(100)(312) and 2.4975(56)(230). The chemical composition determined by the electron-microprobe analysis is (wt.%): Na2O 10.77, K2O 0.20, MgO 11.10, CuO 15.38, ZnO 5.61, SO3 56.42, total 99.48. The empirical formula based on O = 32 apfu is (Na3.93K0.05)Σ3.98Mg3.12(Cu2.19Zn0.78)Σ2.97S7.97O32. The simplified formula is Na2CuMg2(SO4)4 taking into account structural data. The crystal structure was solved by direct methods and refined to an agreement index R1 = 0.034 on the basis of 1855 independent observed reflections. The structure of itelmenite is based on a unique type of [A2+3(SO4)4]2– (A = Mg, Cu and Zn) heteropolyhedral framework with voids filled by Na+ cations.
Redcanyonite, (NH4)2Mn[(UO2)4O4(SO4)2](H2O)4, a new zippeite-group mineral from the Blue Lizard mine, San Juan County, Utah, USA
Authors: Olds Travis A. , Plášil Jakub , Kampf Anthony R. , Burns Peter C. , Nash Barbara P. , Marty Joe , Rose Timothy P. , Carlson Shawn M. 
Published: May 2018

ABSTRACTRedcanyonite (IMA2016-082), (NH4)2Mn[(UO2)4O4(SO4)2](H2O)4, occurs underground in the Blue Lizard mine, Red Canyon, White Canyon district, San Juan County, Utah, USA. It occurs with natrozippeite, brochantite, devilline, posnjakite, johannite, gypsum, bobcookite, pickeringite, pentahydrite and the NH4-analogue of zippeite: ammoniozippeite. Redcanyonite occurs as radial aggregates of red–orange needles and blades individually reaching up to 0.2 mm long, with aggregates measuring up to 1 mm in diameter. Crystals are flattened on {010} and elongated along [100], exhibit perfect cleavage on {010}, and exhibit the forms {010}, {001}, {101} and {10$\bar{1}$}. Twinning is ubiquitous, by 180° rotation on [100]. Redcanyonite is translucent with a pale orange streak, is non-fluorescent, has a Mohs hardness of 2, and has brittle tenacity with uneven fracture. Optically, redcanyonite is biaxial (+), α = 1.725(3), β = 1.755(3), γ = 1.850(5) (white light); 2V (meas.) = 60(2)°, 2V (calc.) = 61.3°; and dispersion isr<v, very strong. Pleochroism is:X= orange,Y= yellow andZ= orange;Y<<X<Z. The optical orientation isX=b,Y≈c*,Z≈a. The empirical formula is (NH4)2.02(Mn0.49Cu0.09Zn0.06)Σ0.64H+0.72[(UO2)4O4(S0.99P0.01O4)2](H2O)4, based on 4 U and 24 O apfu. Redcanyonite is monoclinic,C2/m,a= 8.6572(17),b= 14.155(3),c= 8.8430(19) Å, β = 104.117(18)°,V= 1050.9(4) Å3andZ= 2. The structure was refined toR1= 0.0382 for 1079 reflections withIobs> 3σI. Uranyl oxo-sulfate sheets in redcanyonite adopt the well-known zippeite topology, which consists of zigzag chains of uranyl pentagonal bipyramids linked by sulfate tetrahedra to form sheets. The sheets are linked to each other through bonds to interlayer NH4+groups and octahedrally coordinated Mn2+, and by hydrogen bonds from H2O groups. Redcanyonite is named for Red Canyon in southeast Utah, USA.
Russoite, NH4ClAs23+O3(H2O)0.5, a new phylloarsenite mineral from Solfatara Di Pozzuoli, Napoli, Italy
Authors: Campostrini Italo , Demartin Francesco , Scavini Marco 
Published: May 2018

AbstractThe new mineral russoite (IMA2015-105), NH4ClAs23+O3(H2O)0.5, was found at the Solfatara di Pozzuoli, Pozzuoli, Napoli, Italy, as a fumarolic phase associated with alacránite, dimorphite, realgar, mascagnite, salammoniac and an amorphous arsenic sulfide. It occurs as hexagonal plates up to ~300 µm in diameter and 15 µm thick, in rosette-like intergrowths. On the basis of powder X-ray diffraction measurements and chemical analysis, the mineral was recognised to be identical to the corresponding synthetic phase NH4ClAs2O3(H2O)0.5. Crystals are transparent and colourless, with vitreous lustre and white streak. Tenacity is brittle and fracture is irregular. Cleavage is perfect on {001}. The measured density is 2.89(1) g/cm3; the calculated density is 2.911 g/cm3. The empirical formula, (based on 4.5 anions per formula unit) is [(NH4)0.94,K0.06]Σ1.00(Cl0.91,Br0.01)Σ0.92As2.02O3(H2O)0.5. Russoite is hexagonal, space group P622, with a = 5.2411(7), c = 12.5948(25) Å, V = 299.62(8) Å3 and Z = 2. The eight strongest X-ray powder diffraction lines are [dobs Å(I)(hkl)]: 12.63(19)(001), 6.32(100)(002), 4.547(75)(100), 4.218(47)(003), 3.094(45)(103), 2.627(46)(110), 2.428(31)(112) and 1.820(28)(115). The structure, was refined to R = 0.0518 for 311 reflections with I > 2σ(I) and shows a different location of the ammonium cation and water molecules with respect to that reported for the synthetic analogue. The mineral belongs to a small group of phylloarsenite minerals (lucabindiite, torrecillasite and gajardoite). It contains electrically neutral As2O3 layers, topologically identical to those found in lucabindiite and gajardoite between which are ammonium cations and outside of which Cl– anions. Water molecules and additional ammonium cations are located in a layer between two levels of chloride anions.
Staročeskéite, Ag0.70Pb1.60(Bi1.35Sb1.35)Σ2.70S6, from Kutná Hora, Czech Republic, a new member of the lillianite homologous series
Authors: Pažout Richard , Sejkora Jiří 
Published: May 2018

ABSTRACTA new mineral species, staročeskéite, ideally Ag0.70Pb1.60(Bi1.35Sb1.35)Σ2.70S6, has been found at Kutná Hora ore district, Czech Republic. The mineral occurs in the late-stage Bi-mineralization associated with other lillianite homologues (gustavite, terrywallaceite, vikingite, treasurite, eskimoite and Bi-rich andorite-group minerals) and other bismuth sulfosalts (izoklakeite, cosalite and Bi-rich jamesonite) in quartz gangue. The mineral occurs as lath shaped crystals or anhedral grains up to 80 µm × 70 µm, growing together in aggregates up to 200 µm × 150 µm across. Staročeskéite is steel-grey in colour and has a metallic lustre, the calculated density is 6.185 g/cm3. In reflected light staročeskéite is greyish white; bireflectance and pleochroism are weak with greyish tints. Anisotropy is weak to medium with grey to bluish grey rotation tints. Internal reflections were not observed. The empirical formula based on electron probe microanalyses and calculated on 11 apfu is: (Ag0.68Cu0.01)Σ0.69(Pb1.56Fe0.01Cd0.01)Σ1.58(Bi1.32Sb1.37)Σ2.69(S6.04Se0.01)Σ6.05. The ideal formula is Ag0.70Pb1.60(Bi1.35Sb1.35)Σ2.70S6, which requires Ag 7.22, Pb 31.70, Bi 26.97, Sb 15.72 and S 18.39 wt.%, total 100.00 wt.%. Staročeskéite is a member of the lillianite homologous series withN= 4. Unlike gustavite and terrywallaceite, staročeskéite, similarly to lillianite, is orthorhombic, space groupCmcm, witha= 4.2539(8),b= 13.3094(8),c= 19.625(1) Å,V= 1111.1(2) Å3andZ= 4. The structure of staročeskéite contains four sulfur sites and three metal sites: one pure Pb site and two mixed sites,M1 (0.52Bi + 0.356Ag + 0.124Sb) andM2 (0.601Sb + 0.259Pb + 0.14Bi). The mineral is characterized by the Bi:Sb ratio 1:1 (Bi/(Bi + Sb) = 0.50) and the Ag++ Bi3+, Sb3+↔ 2 Pb2+substitution (L%) equal to 70%. Thus the mineral lies between two series of the lillianite structures withN= 4, between the lillianite–gustavite series and the andorite series.
Understanding patients' perceptions of asthma control: a qualitative study
Authors: Bidad Natalie , Barnes Neil , Griffiths Chris , Horne Rob 
Published: May 2018

Asthma control is suboptimal for many sufferers despite the existence of effective treatments. Patients' self-management is influenced by their perceptions of asthma and its treatment. This study explored sufferers' perceptions of asthma control and their influence on self-management behaviours.Participants (n=42) recruited from primary and secondary care asthma clinics in London in the UK each underwent a qualitative interview exploring perceptions and experiences of asthma control. Purposive sampling ensured variation in disease severity, degree of asthma control, age and socioeconomic status. Grounded theory was employed in thematic analysis of transcribed interviews.Five themes relating to perceptions of asthma control and self-management were identified: personal meaning of control, intermittent prevention, compromising control to avoid medication, pharmacological agents overemphasised in control and the role of asthma review in control. Within the first theme, some participants had an internal barometer of the level of symptoms that indicated their asthma was getting “out of control” that was set much higher than Asthma Control Test criteria.The findings provide new insights into patients’ perceptions of asthma control. Symptoms indicative of poor control were often tolerated as part of living with asthma. Identification of barriers and drivers to self-management highlight potential targets for strategies aimed at optimising asthma management.
Risk factors for lung disease progression in children with cystic fibrosis
Authors: van Horck Marieke , van de Kant Kim , Winkens Bjorn , Wesseling Geertjan , Gulmans Vincent , Hendriks Han , van der Grinten Chris , Jöbsis Quirijn , Dompeling Edward 
Published: May 2018

To identify potential risk factors for lung disease progression in children with cystic fibrosis (CF), we studied the longitudinal data of all children with CF (aged ≥5 years) registered in the Dutch CF Registry (2009–2014).Lung disease progression was expressed as a decline in lung function (forced expiratory volume in 1 s (FEV1) % pred) and pulmonary exacerbation rate. Potential risk factors at baseline included sex, age, best FEV1% pred, best forced vital capacity % pred, genotype, body mass index z-score, pancreatic insufficiency, medication use (proton pump inhibitors (PPIs), prophylactic antibiotics and inhaled corticosteroids), CF-related diabetes, allergic bronchopulmonary aspergillosis and colonisation withPseudomonas aeruginosa.The data of 545 children were analysed. PPI use was associated with both annual decline of FEV1% pred (p=0.017) and future pulmonary exacerbation rate (p=0.006). Moreover, lower FEV1% pred at baseline (p=0.007), prophylactic inhaled antibiotic use (p=0.006) and pulmonary exacerbations in the baseline year (p=0.002) were related to pulmonary exacerbations in subsequent years.In a cohort of Dutch children with CF followed for 5 years, we were able to identify several risk factors for future exacerbations. In particular, the association between PPI use and lung disease progression definitely requires further investigation.
Handgrip strength in end stage of renal disease—a narrative review
Authors: Oliveira Mariana Cassani , Bufarah Marina Nogueira Berbel , Balbi André Luís 
Published: May 2018

Abstract
Background
Handgrip strength (HS) measures have been associated with nutritional status, morbidity, and mortality in end stage of renal disease (ESRD).

Objective
We aimed to present and discuss the HS method in ESRD patients, by reviewing published studies on the subject.

Methods
PUBMED, MEDLINE, and LILACS databases were consulted, with no filters regarding the date of publication or age of population.

Results
The terms “handgrip strength,” “end stage of renal disease,” and “nutrition status” were used, and 32 articles with publication dates from 1983 to 2017 were included. Handgrip strength is considered a simple and rapid method of assessing muscle function in chronic kidney disease and is an important predictor of nutritional status depletion, development of comorbidities, and early mortality.

Conclusion
There is a lack of studies that analyzed associations between HS and clinical and nutritional outcomes in ESRD. The establishment of HS protocols and reference values in ESRD are necessary, to assist preventive measures of unfavorable outcomes in this population.
Clinical Application of Circulating Tumor Cells and Circulating Tumor DNA in Uveal Melanoma
Authors: Beasley Aaron , Isaacs Timothy , Khattak Muhammad A. , Freeman James B. , Allcock Richard , Chen Fred K. , Pereira Michelle R. , Yau Kyle , Bentel Jaqueline , Vermeulen Tersia , Calapre Leslie , Millward Michael , Ziman Melanie R. , Gray Elin S. 
Published: May 2018

Purpose To evaluate the feasibility of using circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) for the management of uveal melanoma (UM). Patients and Methods Low-coverage whole-genome sequencing was used to determine somatic chromosomal copy number alterations (SCNAs) in primary UM tumors, ctDNA, and whole-genome amplified CTCs. CTCs were immunocaptured using an antimelanoma-associated chondroitin sulfate antibody conjugated to magnetic beads and immunostained for melanoma antigen recognised by T cells 1 (MART1)/glycoprotein 100 (gp100)/S100 calcium-binding protein β (S100β). ctDNA was quantified using droplet digital polymerase chain reaction assay for mutations in the GNAQ, GNA11, PLCβ4, and CYSLTR2 genes. Results SCNA analysis of CTCs and ctDNA isolated from a patient with metastatic UM showed good concordance with the enucleated primary tumor. In a cohort of 30 patients with primary UM, CTCs were detected in 58% of patients (one to 37 CTCs per 8 mL of blood), whereas only 26% of patients had detectable ctDNA (1.6 to 29 copies/mL). The presence of CTCs or ctDNA was not associated with tumor size or other prognostic markers. However, the frequent detection of CTCs in patients with early-stage UM supports a model in which CTCs can be used to derive tumor-specific SCNA relevant for prognosis. Monitoring of ctDNA after treatment of the primary tumor allowed detection of metastatic disease earlier than 18F-labeled fluorodeoxyglucose positron emission tomography in two patients. Conclusion The presence of CTCs in localized UM can be used to ascertain prognostic SCNA, whereas ctDNA can be used to monitor patients for early signs of metastatic disease. This study paves the way for the analysis of CTCs and ctDNA as a liquid biopsy that will assist with treatment decisions in patients with UM.
Remifentanil Induces Cardio Protection Against Ischemia/Reperfusion Injury by Inhibiting Endoplasmic Reticulum Stress Through the Maintenance of Zinc Homeostasis
Authors: Sheng Mingwei , Zhang Ge , Wang Jiannan , Yang Qing , Zhao Huanhuan , Cheng Xinxin , Xu Zhelong 
Published: May 2018

BACKGROUND:
Although it is well known that remifentanil (Rem) elicits cardiac protection against ischemia/reperfusion (I/R) injury, the underlying mechanism remains unclear. This study tested if Rem can protect the heart from I/R injury by inhibiting endoplasmic reticulum (ER) stress through the maintenance of zinc (Zn2+) homeostasis.

METHODS:
Isolated rat hearts were subjected to 30 minutes of regional ischemia followed by 2 hours of reperfusion. Rem was given by 3 consecutive 5-minute infusions, and each infusion was followed by a 5-minute drug-free perfusion before ischemia. Total Zn2+ concentrations in cardiac tissue, cardiac function, infarct size, and apoptosis were assessed. H9c2 cells were subjected to 6 hours of hypoxia and 2 hours of reoxygenation (hypoxia/reoxygenation [H/R]), and Rem was given for 30 minutes before hypoxia. Metal-responsive transcription factor 1 (MTF1) overexpression plasmids were transfected into H9c2 cells 48 hours before hypoxia. Intracellular Zn2+ level, cell viability, and mitochondrial injury parameters were evaluated. A Zn2+ chelator N,N,N′,N′-tetrakis-(2-pyridylmethyl) ethylenediamine (TPEN) or an ER stress activator thapsigargin was administrated during in vitro and ex vivo studies. The regulatory molecules related to Zn2+ homeostasis and ER stress in cardiac tissue, and cardiomyocytes were analyzed by Western blotting.

RESULTS:
Rem caused significant reversion of Zn2+ loss from the heart (Rem + I/R versus I/R, 9.43 ± 0.55 vs 7.53 ± 1.18; P < .05) by suppressing the expression of MTF1 and Zn2+ transporter 1 (ZnT1). The inhibited expression of ER stress markers after Rem preconditioning was abolished by TPEN. Rem preconditioning improved the cardiac function accompanied by the reduction of infarct size (Rem + I/R versus I/R, 21% ± 4% vs 40% ± 6%; P < .05). The protective effects of Rem could be reserved by TPEN and thapsigargin. Similar effects were observed in H9c2 cells exposed to H/R. In addition, MTF1 overexpression blocked the inhibitory effects of Rem on ZnT1 expression and ER stress at reoxygenation. Rem attenuated the collapse of mitochondrial membrane potential (ΔΨm) and the generation of mitochondrial reactive oxygen species by inhibiting ER stress via cardiac Zn2+ restoration (Rem + H/R versus H/R, 79.57% ± 10.62% vs 58.27% ± 4.32%; P < .05).

CONCLUSIONS:
Rem maintains Zn2+ homeostasis at reperfusion by inhibiting MTF1 and ZnT1 expression, leading to the attenuation of ER stress and cardiac injury. Our findings provide a promising therapeutic approach for managing acute myocardial I/R injury.