bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sub‐assemblage testing and fragility analysis of connections of continuous‐plasterboard suspended ceiling systems
Authors: Patnana Venkatesh , Rai Durgesh C. 
Published: October 2024

AbstractPast earthquake reconnaissance reports highlighted extensive seismic damages to suspended ceiling components and connections, including instances of complete ceiling failures. The seismic qualification of these nonstructural elements typically requires comprehensive evaluation through full‐scale shake table testing. However, such experimental evaluation is ordinarily not possible for every change made in various components and connections of ceiling systems due to the cost and effort involved. A feasible alternative is to obtain the behavior of components and connections from sub‐assemblage testing and incorporate them in appropriate numerical ceiling models to derive mechanical responses for developing alternative or new installation schemes. This paper considers critical connections of three continuous‐plasterboard suspended ceiling systems that were evaluated using shake table‐generated motions. The connections were classified according to their attachment to typical floors and walls of building structures, and sub‐assemblage testing was conducted using both monotonic and cyclic displacement loading. The observed failure modes in each connection were detailed, and appropriate damage states were assigned as the basis for constructing connection fragility curves. The results of the sub‐assemblage testing were presented in terms of the hysteresis responses, envelope curves, nonlinear backbone curves, and cumulative energy dissipation curves. Additionally, multilinear models of the connections were derived by approximating nonlinear backbone curves’ initial‐ and post‐yield behaviors. These multilinear models were further idealized to derive three equivalent linearized models for simplified yet reasonably accurate results for linear structural analyses. Finally, fragility curves were derived for all connections, considering their cyclic displacement failure capacities.
Silver Nanoparticles (AgNPs) Act as Nanoelicitors in Melissa officinalis to Enhance the Production of Some Important Phenolic Compounds and Essential Oils
Authors: Coskun Yasemin , Kapdan Goncagul 
Published: October 2024

ABSTRACTNanoparticles (NPs) are well‐known biostimulants in plant biotechnology, utilised to enhance the physical properties of plants and exhibit positive effects on them. The important key role is the most suitable type, effective dose and size of NP to be used in plant tissue culture systems. In this study, various concentrations of silver nanoparticles (AgNPs; 0, 25, 50, 75 and 100 μg L−1) were tested as elicitors in callus culture with the aim of enhancing secondary metabolite production in lemon balm (Melissa officinalis L.). According to the results obtained, callus formation rates have shown an increase in all applications compared to the control group. The highest callus formation, weight and diameter were observed in 50 μg L−1 application. In this application, the callus structure was compact and its colour was green. However, the aromatic compounds, neral and geranial increased significantly in 25 μg L−1 application. The maximum increase in phenolic compounds such as caffeic acid, chlorogenic acid, proto‐catechic acid, hesperidin and p‐coumaric acid was observed in the 75 μg L−1 AgNP and the highest increase in rosmarinic acid compound was determined in the 50 μg L−1 application. The study found that AgNP applications are an effective method for increasing the production of secondary metabolites in medicinal and aromatic plants, such as lemon balm, in vitro.
Voltage and Fuel Utilization Control Strategy for Solid Oxide Fuel Cell Based on Active Disturbance Rejection Control
Authors: Lei Zhengling , Guan Chaojun , Liu Tao , Huo Haibo , Wang Fang , Yao Guoquan 
Published: October 2024

ABSTRACTSolid oxide fuel cell (SOFC) systems have become a research focus because of their clean and high‐efficiency properties. Control of output voltage and fuel utilization is critical to the energy management for multi‐energy systems incorporating SOFC energy supply. However, maintaining precise control of the system's voltage in the presence of perturbations can be challenging. Moreover, the system's voltage control process can lead to fuel utilization fluctuations, which may affect the economy and safety. The design of the controller must meet both of these requirements. The stringent control requirements lead to poor parameter adaptability of existing controllers. This paper designs a nonlinear function and adopts a nonlinear/linear active disturbance rejection controller (ADRC) based on state switching to solve the output voltage tracking control problem of SOFC and maintain the fuel utilization rate in the ideal range. The simulation experimental results show that the proposed method has the advantages of strong and superior parameter adaptability with less control effort, which provides theoretical guidance for the design of the output voltage controller of the actual SOFC system.
Pemetrexed‐carboplatin salvage therapy in advanced thyroid cancers
Authors: Lee Kenzie K. , Morris John C. , Kumar Aditi , Chintakuntlawar Ashish V. , Peskey Candy , Hilger Crystal R. , Bible Keith C. , Ryder Mabel 
Published: October 2024

AbstractBackgroundThe overall survival of patients with advanced thyroid cancers that have progressed following targeted therapies is limited, indicating a strong need for salvage treatments.MethodsWe retrospectively analyzed patients with refractory advanced thyroid cancer treated with pemetrexed‐carboplatin (PC) at Mayo Clinic since 2019.ResultsEleven patients, three with anaplastic thyroid cancer (ATC), seven with differentiated or poorly differentiated thyroid cancer (DTC), and one with oncocytic carcinoma of the thyroid, were treated with novel salvage PC. Patients with DTC (n = 7) had durable responses with a median progression‐free survival of 29 months. One responder included a patient with ATC whose disease progressed following pembrolizumab/axitinib, lenvatinib, and dabrafenib/trametinib. On this fourth line treatment, the patient remains on therapy to date, over 12 months after initial response.ConclusionsThis case series reinforces prior published phase I clinical trial data and shows that pemetrexed can have potent efficacy in the treatment of the most advanced thyroid cancers.
Increased PD‐1/PD‐L1 Immune Checkpoint Expression Is Associated With Oral Squamous Cell Carcinoma in Never‐Smokers and Never‐Drinkers
Authors: Fiedler Mathias , Off Alisa , Gärtner Andreas , Brockhoff Gero , Eichberger Jonas , Gottsauner Maximilian , Schuderer Johannes G. , Maurer Michael , Bauer Richard J. , Gerken Michael , Reichert Torsten E. , Ettl Tobias , Weber Florian 
Published: October 2024

ABSTRACTBackgroundThis study aimed to explore the disparities in PD‐1 and PD‐L1 expression among oral squamous cell carcinomas (OSCCs) in individuals categorized as never‐smokers/never‐drinkers versus smokers/drinkers.MethodsImmunohistochemical staining for PD‐1 and PD‐L1, along with PDCD1LG2/cen9 dual color probe analysis, was conducted on 130 OSCC specimens from both smoker/drinker and never‐smoker/never‐drinker cohorts. Associations between smoking/drinking status, clinicopathologic data, immunohistochemical antibody expression, fluorescence in situ hybridization, and survival outcomes were assessed.ResultsOSCC in never‐smokers/never‐drinkers exhibited significantly elevated PD‐1 expression (p = 0.003), increased PD‐L1‐TPS expression (p = 0.044), and elevated PD‐L1‐CPS expression (p < 0.001). High PD‐L1‐ICS expression was more prevalent in never‐smokers (p = 0.042). Moreover, never‐smokers and never‐drinkers demonstrated augmented PD‐L1 gene copy numbers (p = 0.081 and p = 0.054, respectively). Increased PD‐L1 gene copy number, particularly amplification, correlated with PD‐L1‐TPS (p = 0.039 and p < 0.001). Conversely, PD‐L1 gene copy loss was associated with negative PD‐L1‐CPS (p = 0.023). Notably, positive PD‐L1‐CPS was significantly linked with improved overall survival (p = 0.023).ConclusionsOSCC arising in never‐smokers/never‐drinkers exhibit heightened PD‐1/PD‐L1 signaling, suggesting potential efficacy of immune checkpoint therapy in this subgroup of tumors.
Can International Classification of Disease Perinatal Mortality (ICD‐PM) be a solution to overcome neglected tragedy? A scoping reviews
Authors: Meraji Marziyhe , Jafari Masoumeh 
Published: October 2024

AbstractIntroductionOver 5 million perinatal deaths occur annually worldwide, with a significant proportion of them being preventable. The International Classification of Disease Perinatal Mortality (ICD‐PM) is the first globally developed classification system for categorizing the causes of perinatal deaths. The objective of this study is to identify and describe the experiences gained from the international utilization of ICD‐PM.MethodA scoping review based on Preferred Reporting Items for Systematic Reviews and Meta‐Analyses Extension for Scoping Reviews (PRISMA‐SCR) was conducted through a comprehensive search using relevant keywords in Web of Science, PubMed, and Scopus from January 2016 to April 20, 2022 to identify relevant studies. The selection of studies was based on predefined inclusion and exclusion criteria. After removing duplicate studies and reviewing titles, abstracts, and full texts, a total of 32 studies were included in the analysis.ResultsThe primary search ended up with 229 studies, of which 32 articles were included in the final analysis. Based on the results of the content analysis conducted on the selected studies, six main themes and eight strategies were identified.ConclusionThe findings suggest that the utilization of ICD‐PM on a global scale has been limited. The forthcoming advancement of ICD presents a chance to assess and enhance ICD‐PM to establish it as a universally recognized standard system for classifying perinatal mortalities.
Supplemental Magnesium Gluconate Enhances Scaffold‐Mediated New Bone Formation and Natural Bone Healing by Angiogenic‐ and Wnt Signal‐Associated Osteogenic Activation
Authors: Bhattarai Govinda , Shrestha Saroj Kumar , Rijal Shankar , Kook Sung‐Ho , Lee Jeong‐Chae 
Published: October 2024

ABSTRACTLocal implantation or supplementation of magnesium gluconate (MgG) is being investigated as an effective approach to bone repair. Although studies have highlighted the possible mechanisms in Mg ion‐stimulated new bone formation, the role of MgG in healing bone defects and the signaling mechanisms are not yet completely understood. In this study, we explored how supplemental MgG has bone‐specific beneficial effects by delivering MgG locally and orally in animal models. We fabricated MgG‐incorporated (CMC‐M) and ‐free chitosan (CMC) scaffolds with good microstructures and biocompatible properties. Implantation with CMC‐M enhanced bone healing in rat model of mandible defects, compared with CMC, by activating Wnt signals and Wnt‐related osteogenic and angiogenic molecules. Oral supplementation with MgG also stimulated bone healing in mouse model of femoral defects along with the increases in Wnt3a and angiogenic and osteogenic factors. Supplemental MgG did not alter nature bone accrual and bone marrow (BM) microenvironment in adult mouse model, but enhanced the functioning of BM stromal cells (BMSCs). Furthermore, MgG directly stimulated the induction of Wnt signaling‐, angiogenesis‐, and osteogenesis‐related molecules in cultures of BMSCs, as well as triggered the migration of endothelial cells. These results suggest that supplemental MgG improves bone repair in a way that is synergistically enhanced by Wnt signal‐associated angiogenic and osteogenic molecules. Overall, this study indicates that supplemental MgG might ameliorate oxidative damage in the BM, improve the functionality of BM stem cells, and maintain BM‐microenvironmental homeostasis.
Isolated Fetal Liver Calcifications: Case Report and Literature Review
Authors: Derme Martina , Vasta Adele , Corigliano Maria Caterina , Arnò Antonio , D'Ambrosio Valentina , Di Mascio Daniele , Rizzo Giuseppe , Giancotti Antonella 
Published: October 2024

ABSTRACTFetal liver calcifications (FLCs) are isolated or multiple areas of increased echogenicity in the fetal liver, with an estimated prevalence of 5–10 per 10 000 births. However, their clinical importance remains still unclear. Although they are often linked to infections, chromosomal disorders, thrombotic events, or tumors, isolated FLCs generally have a favorable outcome. This article aims to present a case of a 29‐year‐old pregnant woman with a low‐risk cfDNA test, who presented for the first trimester screening scan at our hospital at 12 weeks of pregnancy. The morphology scan at 20 weeks and 5 days revealed a normal fetal size with areas of increased echogenicity in the liver. No other fetal issues were identified. The patient was monitored throughout her pregnancy at our center, receiving genetic counseling and tests for detecting cystic fibrosis, STORCH (syphilis, cytomegalovirus, herpes virus 1;2, rubella, and toxoplasma), fetal echocardiography, and MRI, all of which were normal. At 35 weeks and 6 days, the patient gave birth to a healthy male, and all subsequent postnatal examinations confirmed the baby's health. This article aims to offer comprehensive insights into the management and postnatal outcomes of isolated FLCs, based on a review of the literature.
Face‐simple minimal quadrangulations of surfaces
Authors: Abusaif Sarah , Singh Warren , Sun Timothy 
Published: October 2024

AbstractFor each surface besides the sphere, projective plane, and Klein bottle, we construct a face‐simple minimal quadrangulation, that is, a simple quadrangulation on the fewest number of vertices possible, whose dual is also a simple graph. Our result answers a question of Liu, Ellingham, and Ye while providing a simpler proof of their main result. The inductive construction is based on an earlier idea for finding near‐quadrangular embeddings of the complete graphs using the diamond sum operation.
Exploring In Vitro Antibiofilm Potential and In Vivo Toxicity Assessment of Gold Nanoparticles
Authors: Liaqat Iram , Andleeb Saiqa , Naseem Sajida , Ali Abid , Latif Asma Abdul , Aftab Muhamad Nauman , Ali Sikander , Bibi Asia , Mubin Muhammad , Khalid Awais , Afzaal Muhammad , Yang Guo‐Jing , Tufail Shahzad , Ahmad Haroon 
Published: October 2024

ABSTRACTIn this study, biogenically synthesized AuNPs were first characterized via UV visible spectroscopy, SEM, XRD, and FTIR followed by toxicity evaluation using mice model. UV‐visible spectroscopy of biogenic AuNPs showed peaks at 540–549 nm, while FTIR spectrum showed various functional groups involving O–H, Amide I, Amide II, O–H, C–H groups, and so on. SEM showed the size variation from 30 to 60 nm. Antibacterial potential against pathogenic isolates showed bigger ZOI (31.0 mm) against Pseudomonas aeruginosa AuNPs. Antibiofilm activity showing up to 100% inhibition at 90 µg mL−1 concentration of AuNPs. Toxicity evaluation showed LD50 as 70 mg kg−1. Exposure to AuNPs caused significant changes in the levels of serum AST (p < 0.05) at 100–150 mg kg−1 of AuNPs exposure. Histopathology of male albino mice kidney and liver revealed that mice exposed to maximum concentration of AuNPs showed necrosis, cell distortion, and hepatocytes detachment. Present study showed that biologically synthesized AuNPs possess effective antimicrobial and biofilm inhibitory potential. AuNPs strong bactericidal effect even at lower concentration suggest that NPs could have excellent potential for combating pathogens. In conclusion, nanotechnology may revolutionize human life and medical industry by developing innovative drugs with the potential to treat diseases in shorter and noninvasive time period. Hence, in vitro biosafety and experimental observations followed by in vivo outcomes are crucial in shifting the novel therapeutics into medical practice thus leading further into their future development.
Evidence of honey‐processed Astragalus polysaccharides improving intestinal immune function in spleen Qi deficiency mice integrated with microbiomics and metabolomics analysis
Authors: Jia Meng , Yuan Meng , Zhu Xuqi , Lin Danna , Li Xueying , Huang Li , Chen Hongyuan , Rui Wen 
Published: October 2024

AbstractBACKGROUNDRadix Astragali, commonly known as Astragalus, is a traditional medicinal and edible plant valued for its Qi‐tonifying properties. The dosage form of Radix Astragali processed with honey, known as honey‐processed Astragalus (HPA), shows improved Qi‐tonifying efficacy as compared to the raw product. Polysaccharides are the main bioactive ingredients in its aqueous extract. This study used a multiomics approach integrating microbiomics and metabolomics to elucidate the Qi‐tonifying mechanisms of honey‐processed Astragalus polysaccharides (HAPS).RESULTSHAPS‐treated mice showed improved symptom scores, spleen and thymus indices, serum cytokines (tumor necrosis factor α, interleukin 1β) and intestinal mucosa secretory immunoglobulin A (SIgA) compared to the mice with spleen Qi deficiency. The analysis of gut microbiota indicated that HAPS regulated the relative abundance of Bacteroidetes, Bacteroides, Proteobacteria and Helicobacter, thereby improving intestinal flora dysbiosis in mice with spleen Qi deficiency. Eleven biomarkers in fecal metabolomics analysis were screened and identified, primarily associated with linoleic acid metabolism, sphingolipid metabolism, glycerophospholipid metabolism and biosynthesis of unsaturated fatty acids. Furthermore, comprehensive analyses demonstrated that HAPS regulates palmitic acid and sphingolipid metabolism by modulating the abundance of Bacteroidetes, which in turn increased the levels of intestinal mucosal SIgA and restored intestinal mucosal immune function in mice with spleen Qi deficiency.CONCLUSIONOur findings revealed that HAPS is an essential active ingredient of HPA, and its Qi‐tonifying mechanism is closely related to the improvement of intestinal immune function. These findings lay the foundation for the application of HAPS as an immunomodulatory agent in health and dietary foods. © 2024 Society of Chemical Industry.
Body Mass Index and Breast Cancer‐Related Lymphedema: A Retrospective Cohort Study
Authors: Jiang QiHua , Hu Hai , Liao Jing , Duan Peng , Li ZhiHua , Tan JunTao 
Published: October 2024

ABSTRACTObjectiveThis study aims to evaluate the association between body mass index (BMI) and the incidence of breast cancer‐related lymphedema (BCRL).MethodsThis retrospective cohort study analyzed data from 1464 breast cancer patients treated at The Third Hospital of Nanchang between 2018 and 2021. Patients were categorized based on BMI (<25, 25 to < 30, ≥ 30 kg/m²). Variables such as axillary lymph node dissection, infections, radiotherapy, and comorbidities were taken into account.ResultsThe incidence of BCRL was 23.4%. Higher BMI was associated with increased risk of BCRL, with significant incidence rates observed at 1, 2, and 3 years in the higher BMI groups. Multivariate analysis confirmed BMI as an independent risk factor for BCRL.ConclusionElevated BMI is associated with increased BCRL risk and decreased BCRL‐free survival, underscoring the significance of weight management in breast cancer care.
Predictors of Benignity for Small Endophytic Echogenic Renal Masses
Authors: Chen Anthony F. , Getz Mary Le Dinh , McGahan John P. , Wilson Machelle D. , Larson Michael C. 
Published: October 2024

ObjectivesTo evaluate for distinguishing demographic and sonographic features of small (<3 cm) endophytic angiomyolipomas (AMLs) that differentiate them from endophytic renal cell carcinomas (RCCs).MethodsThis is a Health Insurance Portablitiy and Accountablity Act (HIPAA)‐compliant retrospective review of the demographics and ultrasound features of endophytic renal AMLs compared to a group of endophytic RCCs. AMLs were confirmed by identifying macroscopic fat on computed tomography (CT) or magnetic resonance imaging (MRI), while RCCs were pathologically proven. Statistical analysis was used to compare findings in the 2 groups.ResultsThere were a total of 66 patients with 66 AMLs, and 28 patients with 28 RCCs. Of the AMLs, 57 of 66 were in females, while 10 of the 28 RCC cases were in females (P < .0001). The mean AML long and short diameters were 11.0 × 9.3 mm and were statistically significantly smaller (P < .0001) than the diameters of the RCCs (23.4 × 22.1 mm). Likewise, the ratio of the long axis to the short axis measurement was statistically significantly different between the 2 groups (P < .0001). Of the studied sonographic features, statistically different features between AMLs and RCCs included an oval versus a round shape (P < .001), respectively, and the presence versus absence of an echogenic margin, respectively. Location of the mass, mass homogeneity, mass lobulation, and presence of cystic components were not distinguishing features using P < .01 levels.ConclusionFor an endophytic echogenic mass in a female patient, a small size with an oval shape and an echogenic margin is statistically more likely to be an AML than an RCC, which may be helpful with management decisions.
Is SNOT‐22 a Reliable Tool During Periods of High Stress? A Retrospective Cohort Study
Authors: Book Reut , Lazutkin Anna , Book Aviad , Eliashar Ron 
Published: October 2024

ObjectiveTo assess the impact of a major crisis, such as the October 7, 2023, terror attack, on SNOT‐22 scores, especially the extra‐rhinologic subdomains.MethodsThis retrospective cohort study was conducted at the Rhinology Clinic in a Tertiary University Hospital. Patients who visit our Rhinology Clinic routinely complete the SNOT‐22, a widely employed questionnaire designed for evaluating health‐related quality of life in individuals with rhinologic conditions. Patients were divided into two groups: 5 weeks before the October 7 terror attack and 5 weeks after. Primary outcomes for analyses included the Sedaghat Subdomain model of the SNOT‐22. Descriptive analysis and Welch's t‐test were used to compare SNOT‐22 subdomain scores between groups.ResultsA total of 159 patients completed the SNOT‐22 questionnaire, with 60 before and 99 after October 7, 2023. A general decrease in average scores was observed across all subdomains, with a significant decrease in the Nasal subdomain (p = 0.0388). Subgroup analysis showed an increase in the Ear/Facial subdomain in Arabic and the Sleep and Function subdomains in English, though not statistically significant. In sex‐based sub‐analysis, female patients showed a significant decrease in the Emotions subdomain.ConclusionOur study was unable to establish a direct link between the terror attack and specific SNOT‐22 subdomains. However, the observed trends suggest that SNOT‐22 may display variability or unreliability when used during periods of high stress.Level of EvidenceIII Laryngoscope, 2024