bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of laboratory medicine in collaborative healthcare
Authors: Watson Ian D. , Wilkie Patricia , Hannan Amir , Beastall Graham H. 
Published: April 2018

AbstractHealthcare delivery and responsibility is changing. Patient-centered care is gaining international acceptance with the patient taking greater responsibility for his/her health and sharing decision making for the diagnosis and management of illness. Laboratory medicine must embrace this change and work in a tripartite collaboration with patients and with the clinicians who use clinical laboratory services. Improved communication is the key to participation, including the provision of educational information and support. Knowledge management should be targeted to each stakeholder group. As part of collaborative healthcare clinical laboratory service provision needs to be more flexible and available, with implications for managers who oversee the structure and governance of the service. Increased use of managed point of care testing will be essential. The curriculum content of laboratory medicine training programs will require trainees to undertake practice-based learning that facilitates interaction with patients, clinicians and managers. Continuing professional development for specialists in laboratory medicine should also embrace new sources of information and opportunities for collaborative healthcare.
International normalized ratio (INR) testing in Europe: between-laboratory comparability of test results obtained by Quick and Owren reagents
Authors: Meijer Piet , Kynde Karin , van den Besselaar Antonius M.H.P. , Van Blerk Marjan , Woods Timothy A.L. 
Published: April 2018

Abstract

Background:
This study was designed to obtain an overview of the analytical quality of the prothrombin time, reported as international normalized ratio (INR) and to assess the variation of INR results between European laboratories, the difference between Quick-type and Owren-type methods and the effect of using local INR calibration or not. In addition, we assessed the variation in INR results obtained for a single donation in comparison with a pool of several plasmas.

Methods:
A set of four different lyophilized plasma samples were distributed via national EQA organizations to participating laboratories for INR measurement.

Results:
Between-laboratory variation was lower in the Owren group than in the Quick group (on average: 6.7% vs. 8.1%, respectively). Differences in the mean INR value between the Owren and Quick group were relatively small (<0.20 INR). Between-laboratory variation was lower after local INR calibration (CV: 6.7% vs. 8.6%). For laboratories performing local calibration, the between-laboratory variation was quite similar for the Owren and Quick group (on average: 6.5% and 6.7%, respectively). Clinically significant differences in INR results (difference in INR>0.5) were observed between different reagents. No systematic significant differences in the between-laboratory variation for a single-plasma sample and a pooled plasma sample were observed.

Conclusions:
The comparability for laboratories using local calibration of their thromboplastin reagent is better than for laboratories not performing local calibration. Implementing local calibration is strongly recommended for the measurement of INR.
Standardization of autoimmune testing – is it feasible?
Authors: Monogioudi Evanthia , Martos Gustavo , Hutu Dana Petronela , Schimmel Heinz , Meroni Pier Luigi , Sheldon Joanna , Zegers Ingrid 
Published: April 2018

Abstract
Correct measurement of autoantibodies is essential for the diagnosis of autoimmune diseases. However, due to the variability of autoantibody results and the heterogeneity of testing, wrong diagnosis is a reality. For this and more reasons, harmonization of testing is of the outmost importance. In this review we have summarized the factors contributing to this variability. The ways with which the working group on harmonization of autoantibody testing of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has been trying to tackle the issue with the production and correct use of certified reference materials (CRMs), is discussed. Finally the advantages and the limitations of the use of CRMs are presented.
Serum carbohydrate sulfotransferase 7 in lung cancer and non-malignant pulmonary inflammations
Authors: Debeljak Željko , Dundović Sandra , Badovinac Sonja , Mandić Sanja , Samaržija Miroslav , Dmitrović Branko , Miloš Marija , Maričić Lana , Šerić Vatroslav , Buljanović Vikica 
Published: April 2018

Abstract

Background:
Carbohydrate sulfotransferases (CHST) were shown to be involved in carcinogenesis. The aim of the study was to assess the diagnostic value of serum CHST7 concentration in differentiation between lung cancer and non-malignant pulmonary inflammations.

Methods:
Clinical case-control study involving 125 participants was conducted: the control group containing cases of pneumonia and chronic obstructive pulmonary disease was compared to the lung cancer group composed of primary and metastatic cancers. Serum concentrations of CHST7 and routinely used markers including carcinoembryonic antigen (CEA), cytokeratin fragment 21-1 (CYFRA 21-1) and neuron-specific enolase (NSE) were determined for each participant using immunochemical methods. Statistical association, receiver operating characteristic (ROC) analysis and cross-validation were used for the evaluation of CHST7 either as a standalone biomarker or as a part of a biomarker panel.

Results:
In comparison to the control group, serum CHST7 was elevated in lung cancer (p<0.001), but no differences between the overall stages of primary cancers were detected (p=0.828). The differentiation performance in terms of ROC area under curve (AUC) was 0.848 making CHST7 superior biomarker to the NSE (p=0.031). In comparison to CEA and CYFRA 21-1, the performance differences were not detected. CHST7 was not correlated to other biomarkers, and its addition to the routine biomarker panel significantly improved the cross-validated accuracy (85.6% vs. 75.2%) and ROC AUC (p=0.004) of the differentiation using a machine learning approach.

Conclusions:
Serum CHST7 is a promising biomarker for the differentiation between lung cancer and non-malignant pulmonary inflammations.
Prognostic value of HE4 in patients with ovarian cancer
Authors: Yuan Cunzhong , Li Rongrong , Yan Shi , Kong Beihua 
Published: April 2018

Abstract

Background
There is no consensus in the medical community about the prognostic role of preoperative serum levels of human epididymis protein 4 (HE4) in ovarian cancer (OC). The purpose of this meta-analysis was to establish whether preoperative serum levels of HE4 are associated with OC prognosis.

Content
Eligible studies were searched for in PubMed, ClinicalTrials.gov, CNKI and Wanfang Med Online. We performed a meta-analysis of 1315 OC cases from 14 published articles.

Summary
Our meta-analysis demonstrated that high HE4 was associated with poor overall survival (OS) (random effects model, hazard ratio [HR]=1.91, 95% confidence interval [CI]=1.40–2.614, p<0.0001; I2=52%, p=0.04) and; progression-free survival (PFS) (random effects model, HR=1.38, 95% CI=1.13–1.69, p=0.002; I2=85%, p<0.00001). However, subgroup analysis showed that high HE4 was not associated with poor OS (fixed effects model, HR=1.86, 95% CI=0.89–3.89, p=0.1; I2=34%, p=0.22) or PFS (random effects model, HR=1.34, 95% CI=0.95–1.88, p=0.1; I2=69%, p=0.007) for studies including only Asian populations.

Outlook
In conclusion, this meta-analysis shows that high HE4 was associated with poor OC OS and PFS overall. However, the association of high HE4 with poor OS and PFS was not observed for Asians. Large-scale, multi-center investigations should be performed.
Effects of common hemoglobin variants on HbA1c measurements in China: results for α- and β-globin variants measured by six methods
Authors: Xu Anping , Chen Weidong , Xia Yong , Zhou Yu , Ji Ling 
Published: April 2018

Abstract

Background:
HbA1c is a widely used biomarker for diabetes mellitus management. Here, we evaluated the accuracy of six methods for determining HbA1c values in Chinese patients with common α- and β-globin chains variants in China.

Methods:
Blood samples from normal subjects and individuals exhibiting hemoglobin variants were analyzed for HbA1c, using Sebia Capillarys 2 Flex Piercing (C2FP), Bio-Rad Variant II Turbo 2.0, Tosoh HLC-723 G8 (ver. 5.24), Arkray ADAMS A1c HA-8180V fast mode, Cobas c501 and Trinity Ultra2 systems.

Results:
DNA sequencing revealed five common β-globin chain variants and three common α-globin chain variants. The most common variant was Hb E, followed by Hb New York, Hb J-Bangkok, Hb G-Coushatta, Hb Q-Thailand, Hb G-Honolulu, Hb Ube-2 and Hb G-Taipei. Variant II Turbo 2.0, Ultra2 and Cobas c501 showed good agreement with C2FP for most samples with variants. HLC-723 G8 yielded no HbA1c values for Hb J-Bangkok, Hb Q-Thailand and Hb G-Honolulu. Samples with Hb E, Hb G-Coushatta, Hb G-Taipei and Hb Ube-2 produced significant negative biases for HLC-723 G8. HA-8180V showed statistically significant differences for Hb E, Hb G-Coushatta, Hb G-Taipei, Hb Q-Thailand and Hb G-Honolulu. HA-8180V yielded no HbA1c values for Hb J-Bangkok. All methods showed good agreement for samples with Hb New York.

Conclusions:
Some common hemoglobin variants can interfere with HbA1c determination by the most popular methods in China.
Prevalence, sources and purpose of self-prescribed non-opioid analgesic among health professionals in Sokoto metropolis, Nigeria: a cause for concern
Authors: Fidelis Catherine , Kanmodi Kehinde Kazeem , Olajolumo Johnson 
Published: April 2018

Abstract

Background. Self-medication is defined as the use of medicines without a doctor’s prescription. The non-opioid analgesics (NOAs) constitute one of the most commonly self-prescribed drugs globally. This study aims to determine the prevalence of NOAs self-medication, and also explore the purpose and sources of the self-prescribed NOAs among health professionals in Sokoto metropolis, Nigeria.

Methods. Data obtained from a cross-section of 205 health professionals in Sokoto metropolis, Nigeria, were used for this study. The study tool used was a well-structured questionnaire. Data analysis was done using the SPSS version 20 software.

Results. Only 36.6% of the 205 subjects were within the age range of 26 to 30 years, 38.0% were nurses. The majority (85.9%) of the subjects had self-prescribed NOAs, of which 6.8% of them had a positive history treatment for NOA overdose. Patent medicine stores (43.0%) were reported to be the most common source of acquisition of self-prescribed NOAs. The majority (63.9%) of the subjects used NOAs to get relieved from headaches. Paracetamol (79.0%) and Diclofenac (65.9%) were the top two self-prescribed NOAs among the subjects.

Conclusion. Non-opioid analgesic self-prescription is a popular practice among health professionals in Sokoto metropolis, Nigeria. All the various routes of access (e.g. hospital pharmacy) to NOAs need to be revisited in order to curb the irrational use of NOAs in Nigerian society.
Effects of technogenic pollutants on chicken embryos
Authors: Zinabadinova Sabrie , Lavrinenko Viktoria , Kaminsky Rostislav , Korsak Alina , Sokurenko Liudmyla , Chaikovsky Yuri 
Published: April 2018

Abstract
Increasing interest in nanomaterials can be explained by their broad involvement in many fields of industry and medicine. It is known that carbon black and crysotile asbestos behave like nanosized objects. They are wide spread in environment and have close contact with living organisms. The aim of our study was to define the effects of carbon black and crysotile asbestos on structures of the developing organism.
We used chicken embryos as a model for our study. Total amount of 77 eggs was divided in three groups: one control and two experimental with introduced carbon black and asbestos respectively. Researched materials were injected in the yolk on the third day of incubation and tissues for study were taken during early, middle and late stages of incubation. Histological and electron microscopy methods were used.
Carbon black and asbestos introduction caused underdevelopment of embryos and vessels depletion in blood islands of the yolk sac. Asbestos slowed down angiogenesis. Soot particles caused integrity violation of vessels and led to extravasation. The manifestations of soot influence were damages to blood circulatory system and structural disorders on cellular level. Introduction of chrysotile asbestos mostly resulted in compensatoryadaptive reactions like increasing in hematopoiesis and transcytosis in endotheliocytes.
A Posteriori Error Estimation for Planar Linear Elasticity by Stress Reconstruction
Authors: Bertrand Fleurianne , Moldenhauer Marcel , Starke Gerhard 
Published: April 2018

Abstract
The nonconforming triangular piecewise quadratic finite element space by Fortin and Soulie can be used for the displacement
approximation and its combination with discontinuous piecewise linear pressure elements is known to constitute a stable
combination for incompressible linear elasticity computations. In this contribution, we extend the stress reconstruction
procedure and resulting guaranteed a posteriori error estimator developed by Ainsworth, Allendes, Barrenechea and Rankin
[2] and by Kim [18] to linear elasticity. In order to get a guaranteed reliability bound with respect
to the energy norm involving only known constants, two modifications are carried out: (i) the stress reconstruction in
next-to-lowest order Raviart–Thomas spaces is modified in such a way that its anti-symmetric part vanishes in average on each
element; (ii) the auxiliary conforming approximation is constructed under the constraint that its divergence coincides with the
one for the nonconforming approximation. An important aspect of our construction is that all results hold uniformly in the
incompressible limit. Global efficiency is also shown and the effectiveness is illustrated by adaptive computations
involving different Lamé parameters including the incompressible limit case.
Extension of Caspar-Klug theory to higher order pentagonal polyhedra
Authors: Sadre-Marandi Farrah , Das Praachi 
Published: April 2018

Abstract
Many viral capsids follow an icosahedral fullerene-like structure, creating a caged polyhedral arrangement built entirely from hexagons and pentagons. Viral capsids consist of capsid proteins,which group into clusters of six (hexamers) or five (pentamers). Although the number of hexamers per capsid varies depending on the capsid size, Caspar-Klug Theory dictates there are exactly twelve pentamers needed to form a closed capsid.However, for a significant number of viruses, including viruses of the Papovaviridae family, the theory doesn’t apply. The anomaly of the Caspar-Klug Theory has raised a new question:“For which Caspar and Klug models can each hexamer be replaced with a pentamer while still following icosahedral symmetry?” This paper proposes an answer to this question by examining icosahedral viral capsid-like structures composed only of pentamers, called pentagonal polyhedra. The analysis shows that pentagonal polyhedra fall in a subclass of T, defined by P ≥ 7 and T = 1( mod 3).
Conceptualizations of time in French depuis ‘since, for’ constructions
Authors: Law James 
Published: April 2018

AbstractThe two most common constructions with the French preposition depuis ‘since, for’ represent alternate temporal conceptualizations of events. The temporal point (tp) construction situates events with respect to a starting point in the past from which mental scanning tracks to the present. The temporal duration (td) construction situates events by reference to their duration. Adoption of the Cognitive Grammar framework leads to the insight that all other depuis constructions are variations of the tp construction, while the td construction is distinct in its construal of situations. This corpus study gives an account of how the td construction developed as an extension of the tp construction starting in the fourteenth century, as well as a pragmatic analysis of the contexts that favor use of the td construction in modern French. The findings show that the td construction is nearly always used to emphasize duration for some communicative purpose.
Perpetrators’ strategic communication: Framing and identity building on ethno-nationalist terrorists’ websites
Authors: Rothenberger Liane , An Yulia , Mejía Natalia Angulo , Arizi Arlinda , Villalobos María Martín 
Published: April 2018

Abstract
The study explores communication strategies of ethno-nationalist terrorists with respect to their
framing and identity building. Strategies of eight ethno-nationalist terrorist groups were analyzed using
70 articles published on the groups’ websites. Three cluster-analytic procedures and a correlational
analysis were applied to (1) strategies of problem definition, (2) cause and responsibility attribution,
(3) treatment recommendations, and (4) identity building. The analysis revealed various dimensions
on which terrorists frame their content. No group-specific strategies of framing and identity building
have been found yet, suggesting that the strategies were universal across terrorist groups, and they
were applied on a case-by-case basis. Knowledge about these strategies should advance counter-terrorism
efforts, and assist in development of alternative identities among ethnic groups at risk of conflict.
In memory of Professor Jan Mazurkiewicz in the 70th anniversary of his death
Authors: Perzyńska-Starkiewicz Aneta 
Published: April 2018

Abstract
This article reminisces about the life and career of Jan Mazurkiewicz, one of the most outstanding Polish psychiatrists – the author of Psychophysiological Theory, an original conception of mental disease based on the theory of evolution and dissolution of the nervous system developed by the Englishneurologist John Hughlings Jackson. Professor Jan Mazurkiewicz was an active organizer of psychiatric care. He was co-founder and director of hospitals in Kochanówka and Kobierzyn. He held the rank of Associate Professor at the John Casimir University in Lviv and the position of Professor at the Jagiellonian University in Cracow. From 1919 until his death in 1947, Professor Jan Mazurkiewicz was the head of the Department of Psychiatry at the University of Warsaw. For twenty three years, starting from 1924, he was the president of the Polish Psychiatric Association. The Mazurkiewicz's Psychopathological Theory provides a natural model of development of the highest psychic functions. Damage to a higher evolutionary level of the nervous system leads to the activation of the previously suppressed lower levels, transformed by the pathogen into psychopathological symptoms. Mazurkiewicz's scientific thought was adopted and developed by his student andthen, collaborator, Professor Mieczysław Kaczyński, who was later to become the head of the Department of Psychiatry in Lublin. This work discusses the research conducted at Lublin's Department of Psychiatry which expands on Mazurkiewicz's theory
Treatment-refractory and super refractory schizophrenia - a case study
Authors: Soroka Ewelina , Lesiczka Inga-Ujma , Tracz Magdalena , Bereza Bernarda , Olajossy Marcin 
Published: April 2018

Abstract
Refractoriness affects about 25% of patients treated with antipsychotics, and it is a very big challenge for clinicians. The most commonly accepted definition of refractoriness is: lack of satisfactory clinical response to treatment with at least two antipsychotic drugs, from different groups, carried out at therapeutic doses and for a sufficiently long period.
Aim : The aim of the study is to analyze the case of a patient diagnosed with schizophrenia.
Methods: Analysis of medical records, available literature from recent years on treatment-refractory and super-refractory schizophrenia.
Results: A 53-year-old patient, a bachelor, suffering from paranoid schizophrenia with an extremely severe, non-remission course with drug resistance features. The patient's father and sister also suffer from severe paranoid schizophrenia. The patient became ill at the age of 22. Despite the high doses of clozapine, in a sufficiently long period of time, the patient maintained positive and negative symptoms, cognitive deficits and behavioral disorders. The patient was 14 times psychiatrically hospitalized, twice treated with electro-convulsive therapy, which did not bring results despite the combination of electroconvulsive therapywith psycho pharmacotherapy. In addition, the patient was addicted to benzodiazepines, administered during anxiety and anxiety attacks by the mother, during the described hospitalization, gradually discontinued. Patient after several attempts of committing suicide, with a tendency to self-destructive behavior. The illustrated case meets the criteria of super-refractory schizophrenia (SRS).
Conclusions: 1. The category of refractory schizophrenia encountered in the literature is not a separate diagnostic category - it does not exist in classification systems, therefore we consider the phenomenon / symptom of drug resistance - variously defined. 2. Social relations have a big impact on the functioning of the patient as well as the course of the disease and prognosis (the role of the family). 3. There are numerous methods for the potentiating of clozapine treatment, of which combining clozapine with EC therapy is effective and safe. The strategy for combining clozapine with EC is effective, but not in all patients.
Depression and anxiety disorders in people with diabetes
Authors: Araszkiewicz Aleksander , Mirlak Izabela 
Published: April 2018

Abstract
Introduction: As the global number of diabetes and the burden of depression together with other mental disorders increases, there is a need for better understanding of the connection between these diseases. In patients with diabetes, mental disorders are more common than in the general population, especially anxiety disorders and depression, which are often difficult to detect by health professionals.
Material and methods: Using the keywords searched in the international bibliographic databases: Embase, Medline, Science Direct, Web of Science. We analyzed clinical trials published in English and international journals
Results: Patients with diabetes are exposed to serious physical and mental complications. The occurence of depression and psychiatric disorders among people with diabetes was twice as frequent as in the general population. There are also studies showing a higher risk of suicide among people with diabetes. In addition, patients with both diseases, diabetes and depression, had an increased risk of cardiovascular complications and increased mortality and higher costs of health care. Diabetic patients have increased incidence of anxiety disorders in relation to non-diabetic patients by 20%.
Conclusion: Further researches and integration of medical and psychological treatment are needed. Cooperation between psychiatrists and diabetologists can reduce mental and physical harm in patients with diabetes.
The Liberal Soliloquy: The Elite Expression of Shared Loneliness in Modern European Nationalism and Supranationalism
Authors: Tesler-Mabé Hernan 
Published: April 2018

Abstract
Abstract: In this article, I explore the problem of identity at the national and European levels historically and sociologically, exposing the liberal thread that runs through the nineteenth and twentieth centuries. Looking to key historical and artistic figures, I argue for the continuity between early nationalist and European integrationist impulses, maintaining that-despite their seemingly contradictory essence-the two are bound together by a liberalism (viz. the pursuit of the natural rights of man) they hold in common. I contend that this connection illustrates that the initial efforts to construct the nation in the early nineteenth century and a supranational Europe more than a century later can be understood asidealistic liberal projects that have failed due to the populist turn upon which their success depends, leaving the cultural elites behind both projects in a shared loneliness.