bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kaupunkitila ja kadunnimet
Authors: Tsupari Hannu 
Published: December 2024

Vertailen tutkimuksessani Viipurin keskustan ja muiden kaupunginosien kadunnimiä vuosien 1913–2024 välisenä ajanjaksona. Sovellan tutkimuksessani kielimaisematutkimuksen ja kriittisen onomastiikan metodeja. Tarkasteltavana ovat kadunnimet Suomen suuriruhtinaskunnan (1812–1917), Suomen tasavallan (1917–1944) ja Venäjän federaation (1991–) ajanjaksoilta. Tutkimusaineistona ovat kartat kyseisiltä ajanjaksoilta. Yksi tutkimukseni tavoitteista on selvittää, miten vallanpitäjät käyttävät katujen nimeämistä vallan välikappaleena. Tutkimus on jatkoa aikaisemmalle tutkimukselleni, jossa tutkin Viipurin keskustan kadunnimiä keskiajalta lähtien nykypäivään.
Luokittelin kadunnimet muistonimiin ja ei-muistonimiin. Muistonimet jaoin ideologisiin muistonimiin ja muihin muistonimiin. Ei-muistonimet jaoin puolestaan syntaktis-semanttisen mallin mukaisiin nimeämisperusteisiin ja ryhmänimiin. Artikkelissa selvitetään, millaisia esikaupunkien kadunnimet ovat ja vertaillaan, miten ne poikkeavat keskustan kadunnimistä ja onko muistonimiä keskustan lisäksi myös muissa kaupunginosissa ja millaisia ne ovat.
Tutkimuksesta selviää, että ideologiset muistonimet keskittyvät pääosin keskustaan kaikissa kartoissa. Nyky-Viipuria kuvaavassa vuoden 2024 kartassa ideologisia muistonimiä on keskustan lisäksi erityisen paljon myös ns. Viipurin läntisissä kaupunginosissa. Tämä selittyy kyseisten alueiden vahvalla alueellisella identiteetillä, joka johtuu niiden tärkeästä sotilaallisesta ja puolustuksellisesta merkityksestä Viipurin historiassa. Ei-muistonimien määrä on keskustan ulkopuolella moninkertainen muistonimiin verrattuna kaikissa kolmessa kartassa. Niissä huomio kiinnittyy ryhmänimien suureen määrään.
Implementation of Samba Server Using OpenVPN Based on Single Board Computer (SBC) for Private Cloud Storage
Authors: Pamungkas Dwi Bayu Putra , Isnawaty Isnawaty , Aksara L.M. Fid 
Published: December 2024

In the current digital era, people's need for data storage media that is practical and can be accessed at any time is increasing. This research aims to design and implement a practical cloud-based data storage system using a Raspberry Pi 4 Model B device using the Samba and OpenVPN applications. The system focuses on storing users' data (private cloud), which allows users to directly access files and data via a storage server. The method used in this research includes a literature review to support system development. Testing was carried out to evaluate the security of the system being built by comparing access to private cloud server services before and after using the OpenVPN application. Test results show that using the OpenVPN application increases the security of data exchange, with good encryption in communications between client and server. The resulting system runs according to the initial design and can function as a secure private cloud system. This research can contribute to the development of efficient and secure data storage solutions, as well as show the potential for using the Raspberry Pi as an energy and cost-saving personal cloud server device.
Порівняльний аналіз виконавських інтерпретацій Сонати Й. Брамса № 2 для кларнета (або альта) з фортепіано
Authors: SKOPYCH Alla , TOLPYGO-RUSINA Natalia 
Published: December 2024

Стаття висвітлює дві унікальні інтерпретації сонати Й. Брамса №2 для кларнета (або альта) з фортепіано. Твір Й. Брамса розглянуто з точки зору композиторського задуму (реального, умовно-реального, гіпотетичного). У процесі аналізу сонати визначена її музична і композиційно-драматургічна ідея, що дозволило проаналізувати інтерпретації цього музичного твору у виконавських версіях для кларнета і альта. Порівняльний аналіз виконання цього твору видатними музикантами доводить, що поглиблене занурення у процес осмислення виконавських інтерпретацій музичних творів дозволяє найактивніше проявити себе у навчальної та виконавської діяльності.
High intracranial pressure following endoscopic third ventriculostomy: illustrative case
Authors: Sokol Zachary , Gupta Rohan V. , Ziechmann Robert , Shepard Scott R. 
Published: December 2024

BACKGROUND
Endoscopic third ventriculostomy (ETV) is an effective procedure for the treatment of triventriculomegaly associated with aqueductal stenosis. However, some patients can develop severe and symptomatic intracranial pressure (ICP) elevations in the immediate postoperative period that can be monitored and treated with external ventricular drain (EVD) placement and controlled cerebrospinal fluid (CSF) diversion until the ICP normalizes and symptoms resolve.

OBSERVATIONS
The authors describe the case of a 39-year-old male who underwent ETV and intraoperative EVD placement for obstructive hydrocephalus associated with aqueductal stenosis. The patient was noted to have sustained ICP elevations in the immediate perioperative period but ultimately experienced a successful clinical outcome without requiring a ventriculoperitoneal shunt.

LESSONS
Significant sustained ICP elevations in the immediate postoperative period following ETV can occur and may indicate a prolonged adjustment period. These elevations can be tolerated if the patient’s symptoms and ICP are well controlled, with temporary external CSF diversion if the patient becomes symptomatic, as the ICP will likely normalize with a reassuring clinical outcome.
https://thejns.org/doi/10.3171/CASE24478
PERLINDUNGAN HUKUM TERHADAP ANAK KORBAN CYBERBULLYING DI TINJAU DARI UNDANG- UNDANG NOMOR 11 TAHUN 2008 TENTANG INFORMASI DAN TRANSAKSI ELEKTRONIK
Authors: Rahmah Siti , Darmiwati  
Published: December 2024

Bullying in the world (Cyberbullying) is an act that often occurs, but is often considered trivial even though the impact is very serious. This article examines legal protection for child victims of cyberbullying by outlining legal actions and remedies for child victims of cyberbullying. Cyberbullying is an act of violent crime committed against children as victims in physical, verbal and psychological forms. Cyberbullying is a new criminal phenomenon that must receive special attention from law enforcement. Cyberbullying is the treatment of terror and threats to the victim via online media, also known as the internet. In the case of bullying, usually a large number of people are involved and this behavior is carried out repeatedly to scare or embarrass the person being targeted, this is considered taboo. Generally, cyberbullying is carried out by certain people who want to find as much information as possible from child victims of slander, even threats. This law also explains that children as victims of criminal acts receive special protection where this special protection is provided by the government, regional government and other state institutions. The special protection given to this child includes rapid treatment and/or physical, psychological and social rehabilitation as well as prevention of disease and other health problems. Apart from that, children also have the right to receive psychosocial assistance during treatment until recovery and children also have the right to receive protection and assistance in every judicial process as explained in Law Number 35 of 2014 in conjunction with Law Number 23 of 2002 concerning Child Protection Article 20 which states The state, government, society, family and parents are obliged and responsible for children who are victims of bullying.
OPTIMALISASI PEMBUKTIAN TINDAK PIDANA PEMBUNUHAN BERENCANA PADA KASUS VINA CIREBON
Authors: Candra Firman 
Published: December 2024

Kasus Tindak Pidana Pembunuhan Berencana yang sangat fenomenal dan sedang viral lagi di tahun 2024 adalah pembunuhan berencana dengan dua korban yakni : Muhamad Rizky Rudiana dan Vina, dan terjadi pada hari Sabtu, 27 Agustus 2016 di lahan kosong belakang bangunan showroom mobil seberang SMPN 11 Jl. Perjuangan Majasem Kampung Situgangga Kelurahan Karyamulya Kecamatan Kesambi Kota Cirebon yang dilakukan oleh Terpidana delapan orang yakni Jaya, Supriyanto, Eka Sandi, Hadi Saputra, Eko Ramadhani, Sudirman, Rivaldi Aditya Wardana, dan Saka Tatal dan 3 orang DPO dengan Amar Putusan Majelis Hakim Pengadilan Negeri Cirebon pada tanggal 19 Mei 2017 dan dikuatkan pada Putusan Kasasi Mahkamah Agung yang inkrakht pada tanggal 24 Oktober 2017 : Menyatakan Terdakwa telah terbukti secara sah dan meyakinkan bersalah melakukan tindak pidana, turut serta melakukan pembunuhan berencana dan turut serta melakukan kekerasan memaksa anak melakukan persetubuhan dengannya dan menjatuhkan Pidana Seumur Hidup kecuali Terdakwa Anak Saka Tatal selama 8 tahun.
Association between waist-to-hip ratio and risk of myocardial infarction: a systematic evaluation and meta-analysis
Authors: Zhang Xiaojuan , Yang Liu , Xiao Cong , Li Jiacong , Hu Tao , Li Linfeng 
Published: December 2024

BackgroundMyocardial infarction(MI) is one of the most serious health threats. Despite the increasing number of clinical methods used to predict the onset of MI, the prediction of MI is still unsatisfactory and necessitates new methods.ObjectiveTo systematically review observational studies from the past two decades on the association between waist-to-hip ratio (WHR) and MI risk.MethodsOriginal literature on the correlation between WHR and MI was searched in PubMed, Embase, Web of Science, Cochrane Library, Science Direct, CNKI, and Wanfang up to January 31, 2024. Two researchers independently screened, extracted data, and assessed quality using the Newcastle-Ottawa Scale (NOS) and Revman5.3. Meta-analysis with Stata 16.0 calculated the combined Odd ratio (OR) for WHR and MI risk. Heterogeneity was assessed with the I2 statistic to select the appropriate effects model. Subgroup analysis, meta-regression, sensitivity analysis, and funnel plots tested for heterogeneity and publication bias.ResultsA total of 22 observational studies were included, involving 709,093 participants. The meta-analysis showed that an elevated WHR was significantly associated with an increased risk of MI, with a pooled odds ratio (OR) of 1.98 [95% Confidence interval (CI): 1.75–2.24] and high heterogeneity (I2 = 91.5%, P &lt; 0.0001). Subgroup analysis revealed a stronger association between WHR and MI in women (OR: 1.99, 95% CI: 1.43–2.77) compared to men (OR: 1.74, 95% CI: 1.36–2.22). Regional analysis indicated that the association between WHR and MI risk was highest in Asian populations (OR: 2.93 95% CI: 1.61–5.33), followed by American (OR: 1.73, 95% CI: 1.45–2.08) and European populations (OR: 2.19, 95% CI: 1.49–3.22). Sensitivity analysis demonstrated that the results remained stable after excluding one study.ConclusionIn the general adult population, a higher WHR is a potentially significant association for MI and has predictive value for MI.
College student engagement and success through inclusive learning environment and experiential learning in courses about Israel and Palestine
Authors: Zeedan Rami 
Published: December 2024

IntroductionThis study examines the impact of pedagogical redesign on two courses about Israel and Palestine, focusing on fostering an inclusive learning environment. The project aimed to address challenges such as student retention, attendance, participation, and academic performance by implementing innovative teaching strategies tailored to diverse student backgrounds.MethodsThe redesign incorporated several key interventions: an experiential learning-based final assignment, scaffolded into multiple steps with opportunities for feedback; group discussions to promote active learning and cooperation; and the integration of optional multimedia resources, such as YouTube videos and podcasts, to enhance engagement and time on task. Additionally, students were involved in the evaluation process by providing feedback and were offered the opportunity to publish their final projects on a public website, further incentivizing their work. To examine the effectiveness of these changes, the study employed a mixed-methods approach. This approach involved the collection and analysis of both quantitative data (such as surveys and performance metrics) and qualitative data (such as student feedback and one-way ANOVA analysis) across six undergraduate course offerings between 2019 and 2024.ResultsThe interventions were tested with students from varied backgrounds engaging in complex discussions. The initial findings revealed significant improvements in critical metrics, including reduced drop/fail/withdraw rates, increased time on task, and higher grades. Students demonstrated enhanced engagement and a more positive overall learning experience, indicating the potential for further positive outcomes.DiscussionThe preliminary results suggest that the implemented pedagogical changes effectively created a more inclusive and engaging learning environment. By integrating experiential learning, providing timely feedback, and utilizing diverse resources, the project demonstrated the potential for scalable improvements in student outcomes.
Primary ovarian insufficiency consequence of autoimmune diseases: a bidirectional two-sample Mendelian randomization study
Authors: Du Yongming , Hu Yichao , Sheng Yuehua , Zhu Tianhong , Liu Shenping , Ding Huiqing , Guan Yutao 
Published: December 2024

BackgroundObservational studies suggest the risk of primary ovarian insufficiency (POI) is increased in autoimmune disorders (AIDs), but it is unclear whether there is a causal relationship. Therefore, we aimed to investigate the bidirectional causality between 20 AIDs and POI using Mendelian randomization (MR) analysis.MethodsA bidirectional two-sample MR investigation was designed by using publicly accessible summary-level data from genome-wide association studies (GWAS). The inverse variance weighted (IVW) method was performed as the main analysis, supplemented by several sensitivity analyses. Cochran Q test was used to evaluate SNP estimate heterogeneity. MR-Egger and MR-PRESSO methods were utilized to detect horizontal pleiotropy.ResultsThe MR analyses revealed that genetically determined coeliac disease (CeD) (OR = 1.124, 95% CI 1.033-1.224, P = 0.007), vitiligo (OR = 1.092, 95% CI 1.003-1.188; P = 0.042), systemic lupus erythematosus (SLE) (OR = 1.122, 95% CI 1.030-1.223, P = 0.008), and selective immunoglobulin A deficiency (SIgAD) (OR = 0.866, 95% CI: 0.776-0.967, P = 0.011) exhibited significant causal relationships with POI. We also found suggestive evidence of positive effect of Addison’s disease (AD) towards POI (OR5e-6 = 1.076, 95% CI 1.002-1.154, P = 0.043).ConclusionThis comprehensive MR analysis indicated that SLE, CeD, vitiligo, and AD caused an increased risk of POI, SIgAD was associated with a decreased risk of POI. These insights carry profound clinical implications, particularly emphasizing the early intervention for women with AIDs/POI who wish to preserve their reproductive potential or plan for future pregnancies.
BRAFV600E/pTERT double mutated papillary thyroid cancers exhibit immune gene suppression
Authors: Sigarteu Chindris Ana-Maria , Rivera Michael , Ma Yaohua , Nair Asha , Liu Yi , Wang Xue , Necela Brian M. , Kachergus Jennifer M. , Casler John D. , Brett Christopher , Rivas Mejia Ana M. , Bernet Victor J. , Copland John A. , Knutson Keith L. , Thompson E. Aubrey , Smallridge Robert C. 
Published: December 2024

IntroductionBRAFV600E mutation (BRAFmut) is common in papillary thyroid cancer (PTC), and most patients have an excellent outcome. However, a TERT-promoter mutation (pTERTmut) in the presence of BRAFmut (BRAFmutpTERTmut) has been demonstrated to confer a more aggressive behavior to PTC. Lymphocytic infiltration is often present in PTC. In this study, we sought to decipher the relationship between the BRAF and pTERT mutations and immune gene dysregulation in tumor samples from a cohort of 147 samples of PTC.MethodsThe abundance of 770 immune gene transcripts was determined by multiprex capture/detection and digital counting of mRNA transcripts using the NanoString nCounter® PanCancer Immune Profiling Panel.ResultsWe identified 40 immune transcripts differentially expressed in BRAFmutpTERTmutvs BRAFmutpTERT wildtype (pTERTwt) (P&lt;0.05). Transcripts induced by BRAFmut alone were significantly repressed in BRAFmutpTERTmut samples, such as genes expressed by lymphoid cells, antigen-presenting cells, and cytotoxic cells, including chemokines, cytokines, checkpoint control proteins, interferon downstream markers, TNF superfamily proteins and BMP markers. A validation analysis using 444 samples from The Cancer Genome Atlas (TCGA) PTC dataset yielded similar results. Deconvolution analysis confirmed differences in the immune cell populations such as increased presence of M2 macrophages in the BRAFmutpTERTmut Mayo cohort and a lower abundance of M1 macrophages in the BRAFmutpTERTmut TCGA cohort compared to BRAFmutpTERTwt. Most of the immune gene pathways were enriched in the BRAFmutpTERTwt tumors in both Mayo and TCGA cohorts but not in BRAFmutpTERTmut. BRAFmutpTERTwt had higher stromal lymphocytes infiltration as compared to BRAFwtpTERTwt tumors, corroborating the transcriptomic findings.DiscussionTo our knowledge this is the first report of a potential link between TERT and the immune microenvironment, offering an explanation for the aggressive nature of BRAFmutpTERTmut PTC.
Explore the operational performance of phase change radiation terminal heating system in different heating zones of China
Authors: Zhang Zhen , Yu Xiaoqiang , Li Jie , Wang Lu , Jin Bo , Niu Getu , Yang Zhengliang , Li Chenxia 
Published: December 2024

IntroductionHeating is one of the main factors leading to high energy consumption and serious carbon emissions in buildings. The clean heating system formed by the coupling of phase change building maintenance structure and solar heating system can improve the thermal storage density of the building maintenance structure, while reducing energy consumption in winter while maintaining a comfortable room temperature through stable energy security.MethodsTherefore, a phase change radiation terminal heating (PCRTH) system with the phase change radiation module as the terminal and the solar energy and air energy as the clean heat source is established in this study. Nanjing, Tianjin and Shenyang in China were selected as the study zones which correspond to the hot summer and cold winter zone, the cold zone and the severe cold zone respectively. The operational effect of the PCRTH system in different climate zones was studied, and the parameters of the PCRTH system were optimized by the GenOpt program combined with Hooke-Jeeves optimization algorithm.ResultsThe analysis results show that the cascade phase change radiation terminals in the three zones reduced room temperature fluctuation, energy consumption and carbon dioxide emissions, but the heating cost was higher. After the Hooke-Jeeves optimization algorithm was used to optimize the PCRTH system parameters in three zones, the PCRTH system heating cost was reduced, and the PCRTH system energy consumption and PCRTH system carbon dioxide emissions were further reduced.DiscussionTherefore, the building heating system composed of PCM maintenance structure and renewable energy has great application advantages in maintaining a comfortable room temperature and improving heating system energy conservation and environmental protection.
Development of a fully integrated hydrological fate and transport model for plant protection products: incorporating groundwater, tile drainage, and runoff
Authors: Callaghan Michael V. , Frey Steven K. , Miller Killian , Hwang Hyoun-Tae , Zolfaghari Reza , Hammel Klaus , Berg Steven J. , Sudicky Edward A. 
Published: December 2024

IntroductionPlant protection products (PPPs) such as pesticides and herbicides are experiencing increased use worldwide. In the context of PPP authorization and registration, water exposure assessments (drinking water and aquatic exposure) use numerical modeling to simulate relevant hydrological processes and exposure pathways. A common practice for estimating PPP leaching to groundwater, PPP loading onto surface water via tile drainage, or PPP transport via runoff utilizes multiple one-dimensional models, each representing a separate exposure pathway. Separate analysis of individual exposure pathways can result in disparate assumptions being made that represent relative worst-case scenarios for each pathway, rather than an integrated reasonable worst-case scenario for all pathways.MethodsThe interplay between PPP degradation, leaching to groundwater, transport in tile drainage, and runoff is well-suited for simulation using an integrated surface–subsurface hydrologic and chemical fate and transport model. This study presents functionality added to HydroGeoSphere (HGS), a three-dimensional, fully integrated, surface–subsurface hydrologic model. HGS was verified against other recognized models: PRZM, HYDRUS, PEARL, PELMO, and MACRO. Added features include automatic irrigation, non-linear adsorption, temperature and soil water content-dependent degradation, and solute uptake by plant roots.Results and DiscussionHGS results for leaching of PPP mass to groundwater showed the highest correlation, lowest error, and lowest bias relative to PEARL model results. Simulation of macropore flow to tile drains in HGS produced an intermittent tile drain flow in summer that resulted in generally lower peak effluent concentrations compared to the MACRO model. Simulation of runoff in HGS produced a higher total runoff compared to the PRZM model, attributed to lower evapotranspiration in HGS. Use of the integrated HGS model resulted in a greater agreement in water balance components relative to using multiple models to simulate individual hydrologic pathways.
Innovative strategies to optimise colorectal cancer immunotherapy through molecular mechanism insights
Authors: Lin Quanjun , Wang Zhiqiang , Wang Jue , Xu Ming , Zhang Xinyi , Sun Peng , Yuan Yihang 
Published: December 2024

BackgroundColorectal cancer (CRC) is a leading cause of cancer-related deaths globally. The heterogeneity of the tumor microenvironment significantly influences patient prognosis, while the diversity of tumor cells shapes its unique characteristics. A comprehensive analysis of the molecular profile of tumor cells is crucial for identifying novel molecular targets for drug sensitivity analysis and for uncovering the pathophysiological mechanisms underlying CRC.MethodsWe utilized single-cell RNA sequencing technology to analyze 13 tissue samples from 4 CRC patients, identifying key cell types within the tumor microenvironment. Intercellular communication was assessed using CellChat, and a risk score model was developed based on eight prognostic genes to enhance patient stratification for immunotherapeutic approaches. Additionally, in vitro experiments were performed on DLX2, a gene strongly associated with poor prognosis, to validate its potential role as a therapeutic target in CRC progression.ResultsEight major cell types were identified across the tissue samples. Within the tumor cell population, seven distinct subtypes were recognized, with the C0 FXYD5+ tumor cells subtype being significantly linked to cancer progression and poor prognosis. CellChat analysis indicated extensive communication among tumor cells, fibroblasts, and immune cells, underscoring the complexity of the tumor microenvironment. The risk score model demonstrated high accuracy in predicting 1-, 3-, and 5-year survival rates in CRC patients. Enrichment analysis revealed that the C0 FXYD5+ tumor cell subtype exhibited increased energy metabolism, protein synthesis, and oxidative phosphorylation, contributing to its aggressive behavior. In vitro experiments confirmed DLX2 as a critical gene associated with poor prognosis, suggesting its viability as a target for improving drug sensitivity.ConclusionIn summary, this study advances our understanding of CRC progression by identifying critical tumor subtypes, molecular pathways, and prognostic markers that can inform innovative strategies for predicting and enhancing drug sensitivity. These findings hold promise for optimizing immunotherapeutic approaches and developing new targeted therapies, ultimately aiming to improve patient outcomes in CRC.