bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiographic alveolar bone morphology and progressive periodontitis
Authors: Rams Thomas E. , Listgarten Max A. , Slots Jørgen 
Published: February 2018

AbstractBackgroundThis study evaluated the relationship between radiographic crestal alveolar bone morphology and progressive periodontitis.MethodsA total of 1,356 posterior interproximal sites in 56 adults treated for chronic periodontitis and receiving systematic 3‐month maintenance care were scored for angular or horizontal marginal bone morphology, as well as for alveolar crestal lamina dura, on radiographs obtained at baseline of a 30‐month post‐treatment period. Semi‐annually, the study patients were clinically evaluated for progressive periodontitis. Logistic regression analysis assessed baseline parameters to progressive periodontitis over the 30‐month post‐treatment period.ResultsProgressive periodontitis was detected at 33 (2.4%) posterior interproximal sites in 20 (35.7%) patients. Sites with post‐treatment angular bony defects developed progressive periodontitis more frequently (14.7%) than sites with a horizontal bone topography (1.8%). Angular bony defects (odds ratio = 10.6) and periodontal probing depths ≥5 mm (odds ratio = 4.2) were identified as statistically significant independent predictors of progressive periodontitis at posterior interproximal sites. Angular bony and horizontal lesions with intact radiographic lamina dura revealed an absence of progressive periodontitis through 24 months.ConclusionsPost‐treatment presence of angular bone morphology and periodontal probing depths ≥5 mm significantly increased risk of progressive periodontitis at posterior interproximal sites. Sites of all morphology and probing depth that displayed radiographic crestal lamina dura at post‐treatment baseline exhibited clinical stability for ≥24 months.
Age‐dependent prediction of visible differences in displayed images
Authors: Mantiuk Rafał K. , Ramponi Giovanni 
Published: February 2018

AbstractA comprehensive computational model of the human visual system has been developed to predict just‐noticeable differences between a pair of stimuli. The stimuli are provided as high‐dynamic‐range, multichannel images, containing accurate spectral and photometric description of the scene. In this work, we extend such a model to determine the effect of age on the sensitivity of the visual system. The extensions are based on the existing models of disability glare, aging of the crystalline lens, and reduced pupil size with age (senile miosis). We confirm findings from other studies that those optical effects cannot fully explain the effect of aging, and we attribute the remaining drop of sensitivity to neural changes. The complete model, including an empirical neural component, can well explain the differences in contrast sensitivity between old and young observers.
Food tourism subsegments: A data‐driven analysis
Authors: Robinson Richard N.S. , Getz Don , Dolnicar Sara 
Published: February 2018

AbstractThe demand side food tourism literature is underdeveloped with gaps in knowledge regarding the particular characteristics of the “foodies” market. Shortcomings in previous approaches have inhibited determining whether the food tourism market is behaviourally homogeneous or whether it is more nuanced. The omnivore–univore theory frames this data‐driven analysis segmentation study. The 4 food‐related travel preference segments that emerge are interpreted as distinct. Our analysis focuses on 2 particular segments. This has practical implications, especially for food tourism stakeholders in marketing but also has implications for tourism researchers more broadly, to reconsider the previously assumed homogeneity of other travel markets.
Preoperative Axillary Ultrasound in the Selection of Patients With a Heavy Axillary Tumor Burden in Early‐Stage Breast Cancer: What Leads to False‐Positive Results?
Authors: Zhu Ying , Zhou Wei , Jia Xiao‐hong , Huang Ou , Zhan Wei‐wei 
Published: February 2018

ObjectivesTo determine whether imaging and clinicopathologic features could predict false‐positive axillary ultrasound (US) results in the selection of patients with breast cancer who had a heavy axillary tumor burden (≥3 tumor‐involved nodes).MethodsAmong 788 patients with histologically confirmed invasive breast cancer at Ruijin Hospital from October 2014 to September 2015, 162 patients (cT1‐T2, cN0) with 167 axillae had suspicious axillary US findings. Ultrasound findings were considered suspicious for metastasis if cortical thickening of greater than 3 mm or effacement of the fatty hilum was present. The false‐positive rate of suspicious axillary US results for identifying 3 or more positive lymph nodes in the final pathologic examination was calculated. Univariate and multivariate analyses were used to evaluate imaging and clinicopathologic factors related to the false‐positive results.ResultsAxillary US showed a false‐positive rate of 60.5% (101 of 167) in the patients with breast cancer and a heavy nodal burden. By logistic regression analyses, we found false‐positive axillary US results more frequently in patients who had a T1 stage tumor (P = .005), an estrogen receptor/progesterone receptor–negative tumor (P < .001), solitary suspicious nodes identified on axillary US (P < .001), and a cortical thickness of the most suspicious lymph node of 3.5 mm or less (P = .015).ConclusionsImaging and clinicopathologic features can be used to identify axillae with less than 3 metastatic nodes in patients with early‐stage breast cancer who have positive axillary US results. In the post–American College of Surgeons Oncology Group Z0011 trial era, conducting a secondary evaluation either clinically or by axillary imaging before the use of a US‐guided biopsy of suspicious nodes can potentially avoid the additional morbidity of axillary lymph node dissection and reduce the preoperative workload.
Comparison of Ultrasound Elastography and Color Doppler Ultrasonography for Distinguishing Small Triple‐Negative Breast Cancer From Fibroadenoma
Authors: Yeo Soo Hyun , Kim Ga Ram , Lee Su Hyun , Moon Woo Kyung 
Published: February 2018

ObjectivesTo compare the performance of ultrasound elastography and color Doppler ultrasonography (US) in distinguishing small, oval, or round triple‐negative breast cancer from fibroadenoma and the influence on the further management decision at US.MethodsIn total, 131 biopsy‐proven oval or round fibroadenomas (n = 68) and triple‐negative breast cancers (n = 63) smaller than 2 cm were included. Three blinded readers assessed the images from US, elastography, and color Doppler imaging according to the Breast Imaging Reporting and Data System lexicon independently. Interobserver agreement was assessed, and sensitivity, specificity, accuracy, and area under the receiver operating characteristic curve values for each data set were compared. Pathologic results were reference standards.ResultsThe interobserver agreements were excellent (intraclass correlation coefficients, 0.856 for US, 0.948 for elastography, and 0.864 for color Doppler). The specificity and accuracy of US with elastography were increased compared with US alone or US with Doppler imaging without statistically significant differences in sensitivity. The average area under the curve for US with elastography (0.869) was increased compared with US alone (0.650) or US with color Doppler (0.576).ConclusionsElastography is more useful than color Doppler imaging for distinguishing small, oval, or round triple‐negative breast cancer from fibroadenoma, and elastography can help avoid biopsy of benign masses.
Object‐oriented soil erosion modelling: A possible paradigm shift from potential to actual risk assessments in agricultural environments
Authors: Borrelli Pasquale , Meusburger Katrin , Ballabio Cristiano , Panagos Panos , Alewell Christine 
Published: February 2018

AbstractOver the last 2 decades, geospatial technologies such as Geographic Information System and spatial interpolation methods have facilitated the development of increasingly accurate spatially explicit assessments of soil erosion. Despite these advances, current modelling approaches rest on (a) an insufficient definition of the proportion of arable land that is exploited for crop production and (b) a neglect of the intra‐annual variability of soil cover conditions in arable land. To overcome these inaccuracies, this study introduces a novel spatio‐temporal approach to compute an enhanced cover‐management factor (C) for revised universal soil loss equation‐based models. It combines highly accurate agricultural parcel information contained in the Land Parcel Identification System with an object‐oriented Landsat imagery classification technique to assess spatial conditions and interannual variability of soil cover conditions at field scale. With its strong link to Land Parcel Identification System and Earth observation satellite data, the approach documents an unprecedented representation of farming operations. This opens the door for the transition from the currently used potential soil erosion risk assessments towards the assessment of the actual soil erosion risk. Testing this method in a medium‐size catchment located in the Swiss Plateau (Upper Enziwigger River Catchment), this study lays an important foundation for the application of the very same methods for large‐scale or even pan‐European applications. Soil loss rates modelled in this study were compared with the insights gained from emerging techniques to differentiate sediment source contribution through compound‐specific isotope analysis on river sediments. The presented technique is adaptable beyond revised universal soil loss equation‐type soil erosion models.
The impact of money attitudes and global life satisfaction on the maladaptive pursuit of consumption
Authors: Harnish Richard J. , Bridges K. Robert , Nataraajan Rajan , Gump Joshua T , Carson Alicia E. 
Published: February 2018

AbstractThe goal of this research was to examine how money attitudes and global life satisfaction relate to and predict compulsive buying among young adults. Using aProlific Academicsample, 265 adults between the ages 18 and 25 completed the Money Attitudes Scale, Money Ethics Scale, Spendthrift‐Tightwad Scale, Satisfaction with Life Scale, and the Richmond Compulsive‐Buying Scale. As expected, motives toward saving and spending money as assessed by the Money Attitude Scale and pain of paying as assessed by the Spendthrift‐Tightwad Scale were correlated and predicted compulsive buying. However, these findings are qualified by an interaction effect such that those who held negative attitudes toward saving money and experienced little pain of paying were compulsive buyers. Theoretical and practical implications for maladaptive purchasing behavior among young adults are discussed.
Dual‐polarity slice‐GRAPPA for concurrent ghost correction and slice separation in simultaneous multi‐slice EPI
Authors: Hoge W. Scott , Setsompop Kawin , Polimeni Jonathan R. 
Published: February 2018

PurposeA ghost correction strategy for Simultaneous Multi‐Slice (SMS) EPI methods that provides improved ghosting artifact reduction compared to conventional methods is presented. Conventional Nyquist ghost correction methods for SMS‐EPI rely on navigator data that contain phase errors from all slices in the simultaneously acquired slice‐group. These navigator data may contain spatially nonlinear phase differences near regions of B0 inhomogeneity, which violates the linear model employed by most EPI ghost correction algorithms, resulting in poor reconstructions.MethodsDual‐Polarity GRAPPA (DPG) was previously shown to accurately model and correct both spatially nonlinear and 2D phase errors in conventional single‐slice EPI data. Here, an extension we call Dual‐Polarity slice‐GRAPPA (DPsG) is adapted to the slice‐GRAPPA method and applied to SMS‐EPI data for slice separation and ghost correction concurrently—eliminating the need for a separate ghost correction step while also providing improved slice‐specific EPI phase error correction.ResultsImages from in vivo SMS‐EPI data reconstructed using DPsG in place of conventional Nyquist ghost correction and slice‐GRAPPA are presented. DPsG is shown to reduce ghosting artifacts and provide improved temporal SNR compared to the conventional reconstruction.ConclusionThe proposed use of DPsG for SMS‐EPI reconstruction can provide images with lower artifact levels, higher image fidelity, and improved time‐series stability compared to conventional reconstruction methods.
Mobile Microscopy and Automated Image Analysis
Authors: Pfeil Juliane , Frohme Marcus , Schulze Katja 
Published: February 2018

AbstractMobile microscopy and automated image analysis are powerful techniques for many applications. A mobile system that consists of a smartphone, an optical attachment and automated image recognition software in a cloud laboratory and its current and possible future applications are described in this article. The idea is to create a very fast, cheap, location‐ and knowledge‐independent system for many use cases.
Multiphoton Tomography for In Vivo Skin‐Age Determination
Authors: Schindele A. , Breunig H. G. , König K. 
Published: February 2018

AbstractNothing represents our age better than our most outer layer: the skin. But the age of the skin may differ from the person's chronological age due to a complex interplay of external and internal factors. A non‐invasive method to determine the skin age on a microscopic level in vivo is clinical multiphoton tomography which allows for direct non‐invasive imaging of biological tissue with subcellular resolution.
Preferences for physician weight status among women with overweight
Authors: Goldring M. R. , Persky S. 
Published: February 2018

SummaryBackgroundWomen with overweight experience stigma in clinical interactions. Emerging evidence suggests that one near‐term approach to offset the negative consequences of weight stigma could be to capitalize on benefits of patient–physician weight concordance. However, it is likely that patient attitudes towards physicians with overweight are complicated and multifaceted and may include stigmatization of providers with overweight.MethodsTwo‐hundred ninety‐eight women with overweight completed an online questionnaire and indicated preference for a physician who is ‘overweight’, ‘not overweight’, or indicated no preference. Participants provided reasons for their choice and answered questions about their weight‐related beliefs and experiences.ResultsThe majority of women indicated no weight preference (63%), and a portion (36%) of the sample explicitly preferred physicians who are not overweight. Reasons provided for these preferences were primarily based on stereotyped notions of physician aptitude based on weight. Compared with having no preference, those who preferred physicians who are not overweight had fewer previous negative weight‐related physician interactions and had increased beliefs about the controllability of weight.ConclusionsThese findings elucidate patient attitudes towards physicians with overweight in a sample at increased risk for weight stigmatization. Findings underscore the need for stigma‐reducing interventions so that clinical experiences for both women and physicians with overweight can be improved.
Discovery and Validation of Novel Protein Biomarkers in Ovarian Cancer Patient Urine
Authors: Sandow Jarrod J. , Rainczuk Adam , Infusini Giuseppe , Makanji Ming , Bilandzic Maree , Wilson Amy L. , Fairweather Nicole , Stanton Peter G. , Garama Daniel , Gough Daniel , Jobling Thomas W. , Webb Andrew I. , Stephens Andrew N. 
Published: February 2018

PurposeFor the vast majority of ovarian cancer patients, optimal surgical debulking remains a key prognostic factor associated with improved survival. A standardized, biomarker‐based test, to preoperatively discriminate benign from malignant disease and inform appropriate patient triage, is highly desirable. However, no fit‐for‐purpose biomarkers have yet been identified.Experimental designWe conducted a pilot study consisting of 40 patient urine samples (20 from each group), using label‐free quantitative (LFQ) mass spectrometry, to identify potential biomarker candidates in urine from individual ovarian cancer patients. To validate these changes, we used parallel reaction monitoring (PRM) to investigate their abundance in an independent validation cohort (n = 20) of patient urine samples.ResultsLFQ analyses identified 4394 proteins (17 027 peptides) in a discovery set of 20 urine samples. Twenty‐three proteins were significantly elevated in the malignant patient group compared to patients with benign disease. Several proteins, including LYPD1, LYVE1, PTMA, and SCGB1A1 were confirmed to be enriched in the urine of ovarian cancer patients using PRM. We also identified the established ovarian cancer biomarkers WFDC2 (HE4) and mesothelin (MSLN), validating our approach.Conclusions and clinical relevanceThis is the first application of a LFQ‐PRM workflow to identify and validate ovarian cancer–specific biomarkers in patient urine samples.
Introduction of an algorithm for planning of autologous fibular transfer in mandibular reconstruction based on individual bone curvatures
Authors: Raith Stefan , Rauen Alexandra , Möhlhenrich Stephan Christian , Ayoub Nassim , Peters Florian , Steiner Timm , Hölzle Frank , Modabber Ali 
Published: February 2018

AbstractBackgroundReconstruction of the mandible with autologous transplants is a challenging task and current computer‐aided surgical planning remains cumbersome. Thus, the aim of the present study was to create an automated computational approach for this procedure.MethodsThe developed algorithm is based on curves following characteristic anatomical features. Geometrical data from a physiological mandible and a fibula were used to generate six different defects, and geometrical accordance was investigated to demonstrate the applicability of the method with different reconstruction parameters (n = 309).ResultsThe method proved to be applicable, it recognized given clinical constraints and the values of accordance could be used to quantify the success of reconstructions.ConclusionsWith the present approach, the complex three‐dimensional task of mandibular reconstruction was simplified, and thus it allows implementation in clinical routine. The computational planning that is proposed may be used to design cutting guides or as geometrical input data for real‐time navigated surgery.
High Density Energetic Zwitterionic Diazonium 1,2,4‐Triazolate Resulting from an Interesting Bond Cleavage of E‐1,2‐Bis(3,4‐diamino‐1,2,4‐triazol‐5‐yl)‐ethane
Authors: Ma Qing , Zhang Guojie , Li Jie , Liao Longyu , Huang Jinglun , Fan Guijuan , Nie Fude 
Published: February 2018

AbstractAn energetic zwitterion 5‐diazonium‐3‐trinitromethyl‐1,2,4‐triazolate (DTNMTz) was synthesized by an interesting bond cleavage of E‐1,2‐Bis(3,4‐diamino‐1,2,4‐triazol‐5‐yl)‐ethane. Its structure was confirmed by single‐crystal X‐ray diffraction. The physicochemical properties such as electrostatic potential, thermal properties and sensitivity towards impact, friction and electrostatic discharge were evaluated. Its heat of formation, detonation pressure and velocity were calculated. It is worth noting that this zwitterion behaves zero CO2 oxygen balance, and it has high density at ambient temperature (1.89 g cm−3), considerable detonation performance (D: 9317 m s−1, P: 37.6 GPa).
2‐Mercaptoquinoline Analogues: A Potent Antileishmanial Agent
Authors: Koley Suvajit , Tiwari Neeraj , Neelabh  , Singh Rakesh Kumar , Singh Maya Shankar 
Published: February 2018

AbstractLeishmaniases are endemic in various countries and parasite is developing resistance against available drugs. Thus, development of new drugs against Leishmania is an open area of investigation for synthetic organic chemist. In order to meet this challenge, a series of 2‐mercaptoquinoline derivatives have been synthesized and docked into the active site of Trypanothione reductase (TryR) enzyme required for redox balance of parasite. These were screened on promastigote and intracellular amastigote stages of L. donovani and found to show high levels of antileishmanial activity together with no cytotoxicity. Some of the synthesized compounds tested here, exhibited very steady and promising leishmanicidal activity against both promastigotes & intracellular amastigotes form, and the observations have been superbly supported by the docking results.
Chiral Shell Core–Satellite Nanostructures for Ultrasensitive Detection of Mycotoxin
Authors: Cai Jiarong , Hao Changlong , Sun Maozhong , Ma Wei , Xu Chuanlai , Kuang Hua 
Published: February 2018

AbstractHerein, the design of a DNA‐based chiral biosensor is described utilizing the self‐assembly of shell core–gold (Au) satellite nanostructures for the detection of mycotoxin, ochratoxin A (OTA). The assembly of core–satellite nanostructures based on OTA‐aptamer binding exhibits a strong chiral signal with an intense circular dichroism (CD) peak. The integrity of the assembly of core–satellite nanostructures is limited to some extent in the presence of different levels of OTA. Correspondingly, the chiral intensity of assembly is weakened with increasing OTA concentrations, allowing quantitative determination of the target. The developed chiral sensor shows an excellent linear relationship between the CD signal and concentrations of OTA in the range of 0.1–5 pg mL−1 with a limit of detection as low as 0.037 pg mL−1. The effectiveness of the biosensor in a sample of red wine is verified and a good recovery rate is obtained. These results suggest that the strategy has great potential for practical application.
Laparoscopic Versus Open Right Posterior Sectionectomy for Hepatocellular Carcinoma in a High‐Volume Center: A Propensity Score Matched Analysis
Authors: Rhu Jinsoo , Kim Sung Joo , Choi Gyu Seong , Kim Jong Man , Joh Jae‐Won , Kwon Choon Hyuck David 
Published: February 2018

AbstractBackgroundWhile minimal invasive surgery is becoming popular in liver resection, right posterior sectionectomy (RPS) is still considered as a difficult procedure. We summarize the clinical data and investigate the feasibility of laparoscopic right posterior sectionectomy (LRPS) in hepatocellular carcinoma (HCC) by comparing its outcomes with those of open right posterior sectionectomy (ORPS).MethodsWe retrospectively reviewed 191 patients who underwent RPS for HCC during January 2009 to August 2016 at Samsung Medical Center. After 1:2 propensity score matching, 53 patients in LRPS group were matched to 97 patients in ORPS group.ResultsThere was no statistical difference in preoperative data. While operation time was significantly longer in LRPS group (381.1 ± 118.7 vs. 234.4 ± 63.7 min, P < 0.001), transfusion rate (13.2 vs. 2.1%, P = 0.061) and complication rate (9.4 vs. 8.3%, P = 0.709) were not statistically different between groups. Clustered Cox proportional hazards regression analysis for matched paired data showed no difference in both disease‐free survival (P = 0.607) and overall survival (P = 0.858).ConclusionsIn HCC, LRPS can be performed safely compared to ORPS, regarding the operative outcome, patient recovery, and oncological outcomes.