bluuebunny/crossref_metadata_2025_split huggingface dataset:
Response of ‘Russet Burbank’ Seed Tubers Containing Dicamba and Glyphosate
Authors: Geary Nelson D. , Hatterman-Valenti Harlene , Secor Gary A. , Zollinger Richard K. , Robinson Andrew P. 
Published: December 2018

AbstractIncreased use of dicamba and/or glyphosate in dicamba/glyphosate-tolerant soybean might affect many sensitive crops, including potato. The objective of this study was to determine the growth and yield of ‘Russet Burbank’ potato grown from seed tubers (generation 2) from mother plants (generation 1) treated with dicamba (4, 20, and 99 g ae ha−1), glyphosate (8, 40, and 197 g ae ha−1), or a combination of dicamba and glyphosate during tuber initiation. Generation 2 tubers were planted near Oakes and Inkster, ND, in 2016 and 2017, at the same research farm where the generation 1 tubers were grown the previous year. Treatment with 99 g ha−1dicamba, 197 g ha−1glyphosate, or 99 g ha−1dicamba + 197 g ha−1glyphosate caused emergence of generation 2 plants to be reduced by up to 84%, 86%, and 87%, respectively, at 5 wk after planting. Total tuber yield of generation 2 was reduced up to 67%, 55%, and 68% when 99 g ha−1dicamba, 197 g ha−1glyphosate, or 99 g ha−1dicamba + 197 g ha−1glyphosate was applied to generation 1 plants, respectively. At each site year, 197 g ha−1glyphosate reduced total yield and marketable yield, while 99 g ha−1dicamba reduced total yield and marketable yield in some site-years. This study confirms that exposure to glyphosate and dicamba of potato grown for potato seed tubers can negatively affect the growth and yield potential of the subsequently grown daughter generation.
Enhancing Employee Self-Care
Authors: Horstmann David 
Published: December 2018

Abstract. The present study investigates the relationship between health-specific leadership and employee burnout. Health-specific leadership is a domain-specific leadership style that is characterized by the focus of leaders on employee well-being and their intentional support of employee health. Following the theory, I argue that managers influence employee burnout not only directly but also indirectly by encouraging employees to take care of their own health. Further, I extend the scope of previous research and argue that managers’ personal initiative acts as a moderator for health-specific leadership; as indicated by previous research, proactivity is crucial for effective leadership behavior. A cross-sectional questionnaire study (n = 525) was conducted. Health-specific leadership, managers’ personal initiative, employee self-care, and employee burnout symptoms have been measured. A moderated mediation was tested using structural equation modeling. The findings confirm a positive relationship between health-specific leadership and employee burnout. As expected, this relationship is partially mediated by employee self-care. Managers’ personal initiative shows an interaction effect on employee self-care but not on burnout symptoms. The study results verify the concept of health-specific leadership and highlight the importance of proactive leadership behavior as a facilitator for health-specific leadership. Finally, implications for leadership research and practice are provided.
Simulation of Longwave Enhancement in Boreal and Montane Forests
Authors: Todt M. , Rutter N. , Fletcher C. G. , Wake L. M. , Bartlett P. A. , Jonas T. , Kropp H. , Loranty M. M. , Webster C. 
Published: December 2018

AbstractBoreal forests cover about a fifth of seasonally snow‐covered land over the Northern Hemisphere. Enhancement of longwave radiation beneath coniferous forests has been found to impact the surface energy balance and rates of snowmelt. Although the skill of model‐simulated snowmelt has been shown to be lower for forests than for open areas, model intercomparisons and evaluations of model parameterizations have not yet focused on longwave enhancement. This study uses stand‐scale forcing for the simulation of subcanopy longwave radiation by Community Land Model version 4.5 (CLM4.5) and to drive SNOWPACK, a snow model featuring more complex canopy structure, as a benchmark model for CLM4.5. Simulated subcanopy longwave radiation and longwave enhancement are assessed using measurements from forest stands located within perennially snow‐covered regions. These forest stands, of varying canopy density, cover the range of boreal plant functional types in CLM4.5. CLM4.5 is found to overestimate the diurnal range of subcanopy longwave radiation and longwave enhancement, and simulation errors increase with decreasing cloudiness and increasing vegetation density. Implementation of a parameterization of heat storage by biomass reduces simulation errors but only marginally affects the amplitude of diurnal ranges. These results reaffirm previous findings that simulation of subcanopy longwave radiation can be improved by partitioning the vegetation canopy into two layers. Moreover, this study reveals the variations of simulation errors across meteorological conditions and vegetation density, the latter of which is the most important parameter for longwave enhancement independent of vegetation type.
Modeling Geoelectric Fields in Ireland and the UK for Space Weather Applications
Authors: Campanyà J. , Gallagher P. T. , Blake S. P. , Gibbs M. , Jackson D. , Beggan C. D. , Richardson G. S. , Hogg C. 
Published: December 2018

AbstractGeoelectric fields at the Earth's surface caused by geomagnetic storms have the potential to disrupt and damage ground‐based infrastructure such as electrical power distribution networks, pipelines, and railways. Here we model geoelectric fields in Ireland and the UK during both quiet and active time intervals of geomagnetic conditions using measurements from magnetic observatories and electromagnetic tensor relationships. The analysis focused on (1) defining periods of the magnetic field variations that are largely affected by the geomagnetic storms, between 30 and 30,000 s; (2) constraining the electromagnetic tensor relationships that defines the Earth's response to magnetic field variations; (3) implementing and validating two approaches for modeling geoelectric fields based on measurements from magnetic observatories and local and interstation electromagnetic transfer functions; and (4) estimating uncertainties when modeling geoelectric fields. The use of interstation tensor relationships allowed us to differentiate between regional and local geomagnetic sources. We found coherence values of 0.5–0.95, signal‐to‐noise ratio of 1–15 dB, normalized root‐mean‐square values of 0.8–3.4, and root‐mean‐square values of 0.7–84 mV/km. Within these ranges of values, sites in close proximity (<100 km) to a magnetic observatory and not affected by local storms will provide the most accurate results, while sites located at further distances and affected by spatially localized features of the storm will be less accurate. These methods enable us to more accurately model geomagnetically induced currents, and their associated uncertainties, in the British and Irish power networks.
Inverse photonic design of functional elements that focus Bloch surface waves
Authors: Augenstein Yannick , Vetter Andreas , Lahijani Babak Vosoughi , Herzig Hans Peter , Rockstuhl Carsten , Kim Myun-Sik 
Published: December 2018

AbstractBloch surface waves (BSWs) are sustained at the interface of a suitably designed one-dimensional (1D) dielectric photonic crystal and an ambient material. The elements that control the propagation of BSWs are defined by a spatially structured device layer on top of the 1D photonic crystal that locally changes the effective index of the BSW. An example of such an element is a focusing device that squeezes an incident BSW into a tiny space. However, the ability to focus BSWs is limited since the index contrast achievable with the device layer is usually only on the order of Δn≈0.1 for practical reasons. Conventional elements, e.g., discs or triangles, which rely on a photonic nanojet to focus BSWs, operate insufficiently at such a low index contrast. To solve this problem, we utilize an inverse photonic design strategy to attain functional elements that focus BSWs efficiently into spatial domains slightly smaller than half the wavelength. Selected examples of such functional elements are fabricated. Their ability to focus BSWs is experimentally verified by measuring the field distributions with a scanning near-field optical microscope. Our focusing elements are promising ingredients for a future generation of integrated photonic devices that rely on BSWs, e.g., to carry information, or lab-on-chip devices for specific sensing applications.
Glassy carbon microneedles—new transdermal drug delivery device derived from a scalable C-MEMS process
Authors: Mishra Richa , Pramanick Bidhan , Maiti Tapas Kumar , Bhattacharyya Tarun Kanti 
Published: December 2018

AbstractBecause carbon is the basic element of all life forms and has been successfully applied as a material for medical applications, it is desirable to investigate carbon for drug delivery applications, as well. In this work, we report the fabrication of a hollow carbon microneedle array with flow channels using a conventional carbon-microelectromechanical system (C-MEMS) process. This process utilizes the scalable and irreversible step of pyrolysis, where prepatterned SU-8 microneedles (precursor) are converted to glassy carbon structures in an inert atmosphere at high temperature (900 °C) while retaining their original shape upon shrinkage. Once converted to glassy carbon, the microneedles inherit the unique properties of hardness, biocompatibility, and thermal and chemical resistance associated with this material. A comparative study of hardness and Young’s modulus for carbon microneedles and SU-8 microneedles was performed to evaluate the increased strength of the microneedles induced by the C-MEMS process steps. Structural shrinkage of the carbon microneedles upon pyrolysis was observed and estimated. Material characterizations including energy-dispersive X-ray spectroscopy (EDX) and Raman spectroscopy were carried out to estimate the atomic percentage of carbon in the microneedle structure and its crystalline nature, respectively. Our investigations confirm that the microneedles are glassy in nature. Compression and bending tests were also performed to determine the maximum forces that the carbon microneedles can withstand, and it was found that these forces were approximately two orders of magnitude higher than the resistive forces presented by skin. A microneedle array was inserted into mouse skin multiple times and was successfully removed without the breakage of any microneedles.
S100A3 a partner protein regulating the stability/activity of RARα and PML-RARα in cellular models of breast/lung cancer and acute myeloid leukemia
Authors: Gianni Maurizio , Terao Mineko , Kurosaki Mami , Paroni Gabriela , Brunelli Laura , Pastorelli Roberta , Zanetti Adriana , Lupi Monica , Acquavita Andrea , Bolis Marco , Fratelli Maddalena , Rochette-Egly Cecile , Garattini Enrico 
Published: December 2018

AbstractAll trans-retinoic acid (ATRA) is used in the treatment of acute promyelocytic leukemia (APL) and it is a promising agent also in solid tumors. The pharmacological activity of ATRA is mediated by the ligand-activated RAR and RXR transcription factors. In the present study, we define the basal and ATRA dependent RARα interactome in a RARα-overexpressing breast cancer cellular model, identifying 28 nuclear proteins. We focus our attention on the S100A3 calcium-binding protein, which interacts with RARα constitutively. In ATRA-sensitive breast cancer cells, S100A3 binds to RARα in basal conditions and binding is reduced by the retinoid. The interaction of S100A3 with RARα is direct and in lung cancer, APL and acute-myeloid-leukemia (AML) cells. In APL, S100A3 interacts not only with RARα, but also with PML-RARα. The interaction surface maps to the RARα ligand-binding domain, where the I396 residue plays a crucial role. Binding of S100A3 to RARα/PML-RARα controls the constitutive and ATRA-dependent degradation of these receptors. S100A3 knockdown decreases the amounts of RARα in breast- and lung cancer cells, inducing resistance to ATRA-dependent anti-proliferative/differentiating effects. Conversely, S100A3 knockdown in PML-RARα+ APL and PML-RARα− AML cells reduces the amounts of RARα/PML-RARα and increases basal and ATRA-induced differentiation. In this cellular context, opposite effects on RARα/PML-RARα levels and ATRA-induced differentiation are observed upon S100A3 overexpression. Our results provide new insights into the molecular mechanisms controlling RARα activity and have practical implications, as S100A3 represents a novel target for rational drug combinations aimed at potentiating the activity of ATRA.
Selfish, sharing and scavenging bacteria in the Atlantic Ocean: a biogeographical study of bacterial substrate utilisation
Authors: Reintjes Greta , Arnosti Carol , Fuchs B , Amann Rudolf 
Published: December 2018

Abstract
Identifying the roles played by individual heterotrophic bacteria in the degradation of high molecular weight (HMW) substrates is critical to understanding the constraints on carbon cycling in the ocean. At five sites in the Atlantic Ocean, we investigated the processing of organic matter by tracking changes in microbial community composition as HMW polysaccharides were enzymatically hydrolysed over time. During this investigation, we discovered that a considerable fraction of heterotrophic bacteria uses a newly-identified ‘selfish’ mode of substrate processing. We therefore additionally examined the balance of individual substrate utilisation mechanisms at different locations by linking individual microorganisms to distinct substrate utilisation mechanisms. Through FISH and uptake of fluorescently-labelled polysaccharides, ‘selfish’ organisms were identified as belonging to the Bacteroidetes, Planctomycetes and Gammaproteobacteria. ‘Sharing’ (extracellular enzyme producing) and ‘scavenging’ (non-enzyme producing) organisms predominantly belonged to the Alteromonadaceae and SAR11 clades, respectively. The extent to which individual mechanisms prevail depended on the initial population structure of the bacterial community at a given location and time, as well as the growth rate of specific bacteria. Furthermore, the same substrate was processed in different ways by different members of a pelagic microbial community, pointing to significant follow-on effects for carbon cycling.
Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population
Authors: Zhao Lijuan , Chang Hong , Zhou Dong-Sheng , Cai Jun , Fan Weixing , Tang Wei , Tang Wenxin , Li Xingxing , Liu Weiqing , Liu Fang , He Yuanfang , Bai Yan , Sun Yan , Dai Jiapei , Li Lingyi , Xiao Xiao , Zhang Chen , Li Ming 
Published: December 2018

AbstractGenetic analyses of psychiatric illnesses, such as bipolar disorder (BPD), have revealed essential information regarding the underlying pathological mechanisms. While such studies in populations of European ancestry have achieved prominent success, understanding the genetic risk factors of these illnesses (especially BPD) in Chinese population remains an urgent task. Given the lack of genome-wide association study (GWAS) of BPD in Chinese population from Mainland China, replicating the previously reported GWAS hits in distinct populations will provide valuable information for future GWAS analysis in Han Chinese. In the present study, we have recruited 1146 BPD cases and 1956 controls from Mainland China for genetic analyses, as well as 65 Han Chinese brain amygdala tissues for mRNA expression analyses. Using this clinical sample, one of the largest Han Chinese BPD samples till now, we have conducted replication analyses of 21 single nucleotide polymorphisms (SNPs) extracted from previous GWAS of distinct populations. Among the 21 tested SNPs, 16 showed the same direction of allelic effects in our samples compared with previous studies; 6 SNPs achieved nominal significance (p < 0.05) at one-tailed test, and 2 additional SNPs showed marginal significance (p < 0.10). Aside from replicating previously reported BPD risk SNPs, we herein also report several intriguing findings: (1) the SNP rs174576 was associated with BPD in our Chinese sample and in the overall global meta-analysis, and was significantly correlated with FADS1 mRNA in diverse public RNA-seq datasets as well as our in house collected Chinese amygdala samples; (2) two (partially) independent SNPs in MAD1L1 were both significantly associated with BPD in our Chinese sample, which was also supported by haplotype analysis; (3) a rare SNP rs78089757 in 10q26.13 region was a genome-wide significant variant for BPD in East Asians, and this SNP was near monomorphic in Europeans. In sum, these results confirmed several significant BPD risk genes. We hope this Chinese BPD case–control sample and the current brain amygdala tissues (with continuous increasing sample size in the near future) will provide helpful resources in elucidating the genetic and molecular basis of BPD in this major world population.
Exosomes—the enigmatic regulators of bone homeostasis
Authors: Gao Minhao , Gao Weiyang , Papadimitriou J. M. , Zhang Changqing , Gao Junjie , Zheng Minghao 
Published: December 2018

AbstractExosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells. Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury.
Assessing the nature of the charge-transfer electronic states in organic solar cells
Authors: Chen Xian-Kai , Coropceanu Veaceslav , Brédas Jean-Luc 
Published: December 2018

AbstractThe charge-transfer electronic states appearing at the donor-acceptor interfaces in organic solar cells mediate exciton dissociation, charge generation, and charge recombination. To date, the characterization of their nature has been carried out on the basis of models that only involve the charge-transfer state and the ground state. Here, we demonstrate that it is essential to go beyond such a two-state model and to consider explicitly as well the electronic and vibrational couplings with the local absorbing state on the donor and/or acceptor. We have thus developed a three-state vibronic model that allows us: to provide a reliable description of the optical absorption features related to the charge-transfer states; to underline the erroneous interpretations stemming from the application of the semi-classical two-state model; and to rationalize how the hybridization between the local-excitation state and charge-transfer state can lead to lower non-radiative voltage losses and higher power conversion efficiencies.
Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia
Authors: Fan Chun Chieh , McGrath John J. , Appadurai Vivek , Buil Alfonso , Gandal Michael J. , Schork Andrew J. , Mortensen Preben Bo , Agerbo Esben , Geschwind Sandy A. , Geschwind Daniel , Werge Thomas , Thompson Wesley K. , Pedersen Carsten Bøcker 
Published: December 2018

AbstractSpatial mapping is a promising strategy to investigate the mechanisms underlying the incidence of psychosis. We analyzed a case-cohort study (n = 24,028), drawn from the 1.47 million Danish persons born between 1981 and 2005, using a novel framework for decomposing the geospatial risk for schizophrenia based on locale of upbringing and polygenic scores. Upbringing in a high environmental risk locale increases the risk for schizophrenia by 122%. Individuals living in a high gene-by-environmental risk locale have a 78% increased risk compared to those who have the same genetic liability but live in a low-risk locale. Effects of specific locales vary substantially within the most densely populated city of Denmark, with hazard ratios ranging from 0.26 to 9.26 for environment and from 0.20 to 5.95 for gene-by-environment. These findings indicate the critical synergism of gene and environment on the etiology of schizophrenia and demonstrate the potential of incorporating geolocation in genetic studies.
Machine learning plastic deformation of crystals
Authors: Salmenjoki Henri , Alava Mikko J. , Laurson Lasse 
Published: December 2018

AbstractPlastic deformation of micron-scale crystalline solids exhibits stress-strain curves with significant sample-to-sample variations. It is a pertinent question if this variability is purely random or to some extent predictable. Here we show, by employing machine learning techniques such as regression neural networks and support vector machines that deformation predictability evolves with strain and crystal size. Using data from discrete dislocations dynamics simulations, the machine learning models are trained to infer the mapping from features of the pre-existing dislocation configuration to the stress-strain curves. The predictability vs strain relation is non-monotonic and exhibits a system size effect: larger systems are more predictable. Stochastic deformation avalanches give rise to fundamental limits of deformation predictability for intermediate strains. However, the large-strain deformation dynamics of the samples can be predicted surprisingly well.
Virus-mediated export of chromosomal DNA in plants
Authors: Catoni Marco , Noris Emanuela , Vaira Anna Maria , Jonesman Thomas , Matić Slavica , Soleimani Reihaneh , Behjatnia Seyed Ali Akbar , Vinals Nestor , Paszkowski Jerzy , Accotto Gian Paolo 
Published: December 2018

AbstractThe propensity of viruses to acquire genetic material from relatives and possibly from infected hosts makes them excellent candidates as vectors for horizontal gene transfer. However, virus-mediated acquisition of host genetic material, as deduced from historical events, appears to be rare. Here, we report spontaneous and surprisingly efficient generation of hybrid virus/host DNA molecules in the form of minicircles during infection of Beta vulgaris by Beet curly top Iran virus (BCTIV), a single-stranded DNA virus. The hybrid minicircles replicate, become encapsidated into viral particles, and spread systemically throughout infected plants in parallel with the viral infection. Importantly, when co-infected with BCTIV, B. vulgaris DNA captured in minicircles replicates and is transcribed in other plant species that are sensitive to BCTIV infection. Thus, we have likely documented in real time the initial steps of a possible path of virus-mediated horizontal transfer of chromosomal DNA between plant species.