bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasound assessment of endothelial dysfunction in Egyptian migraine patients
Authors: Elshebawy Haidy , Mohamed Fahmy Ebtesam , Abd El Fattah Nada Mona , Alaa Abd El Hamid Nouran , Heneidy Sarah 
Published: October 2024

Abstract

Background

It becomes clearer that migraine is associated with vascular risks; however, preclinical vascular involvement is not sufficiently addressed. Evidences point that migraine attacks affect vascular endothelium. The aim of this study was to investigate endothelial dysfunction in migraineurs through assessment of carotid intima-media thickness (CIMT) and flow-mediated dilatation (FMD) of the brachial artery and their correlation with clinical characteristics of migraine, headache severity, and brain magnetic resonance imaging (MRI) findings.

Results
A statistically significant difference was found between migraineurs and controls where carotid IMT was significantly higher and FMD of the brachial artery was significantly lower in migraineurs compared to controls. Carotid IMT was significantly higher and FMD was significantly lower in chronic migraine compared to episodic migraine patients. Mean IMT values were significantly higher in patients receiving ergots and in patients with subcortical white matter lesions in brain MRI. Mean FMD values were significantly lower in patients receiving ergots. There was a significant negative correlation between FMD and carotid IMT, age of the patients, disease duration, duration of headache attacks, headache frequency, and migraine disability assessment questionnaire (MIDAS) score. There were significant positive correlations between carotid IMT and age of patients, disease duration, headache frequency, MIDAS score, and number of MRI white matter lesions. For diagnosing endothelial dysfunction in migraineurs, the sensitivity and specificity of IMT were 72.5 and 70%, respectively, with a cut-off value of 0.575 mm and that of FMD were 82.5 and 90%, respectively, with a cut-off value of 20.55%.

Conclusion
Migraine coincides with endothelial dysfunction which promotes atherogenesis and increased risk of cerebral ischemia. FMD could be used as a potential biomarker for endothelial dysfunction in migraine. The affection of IMT and FMD is more in patients receiving ergots which may influence the selection of treatment in migraineurs in the future.
Fast and accurate short-read alignment with hybrid hash-tree data structure
Authors: Makino Junichiro , Ebisuzaki Toshikazu , Himeno Ryutaro , Hayashizaki Yoshihide 
Published: October 2024

AbstractRapidly increasing the amount of short-read data generated by NGSs (new-generation sequencers) calls for the development of fast and accurate read alignment programs. The programs based on the hash table (BLAST) and Burrows-Wheeler transform (bwa-mem) are used, and the latter is known to give superior performance. We here present a new algorithm, a hybrid of hash table and suffix tree, which we designed to speed up the alignment of short reads against large reference sequences such as the human genome. The total turnaround time for processing one human genome sample (read depth of 30) is just 31 min with our system while that was more than 25 h with bwa-mem/gatk. The time for the aligner alone is 28 min for our system but around 2 h for bwa-mem. Our new algorithm is 4.4 times faster than bwa-mem while achieving similar accuracy. Variant calling and other downstream analyses after the alignment can be done with open-source tools such as SAMtools and Genome Analysis Toolkit (gatk) packages, as well as our own fast variant caller, which is well parallelized and much faster than gatk.
Suicidal transition rates and their predictors in the adult general population: a repeated survey over 21 years in France
Authors: Jollant Fabrice , Leon Christophe 
Published: October 2024

Abstract

Background
The “suicidal transition” from ideation to an act has become a specific topic of research. However, rates in the general population, variations across time and risk factors are unclear.

Methods
Data were collected from the phone survey Baromètre Santé among 18–75-year-olds in France. Seven independent samples interviewed between 2000 and 2021 (total N = 133,827 people; 51.3% females) were questioned about suicidal ideation and attempts over the previous 12 months. Transition was calculated as the weighted ratio of attempt on ideation 12-month rates.

Results
Mean 12-month rates of suicidal ideation, attempts and transition were 4.7% (95% Confidence Interval (CI) (4.6–4.8)), 0.5% (95% CI (0.4–0.5)) and 7.7% (95% CI (6.8–8.6)), respectively. Transition rates varied between 4.5 and 11.9% across surveys. In multivariable analyses, higher transitions rates were associated with a previous suicide attempt (adjusted Odds Ratio (aOR) = 11.1 95% CI (7.9–15.6)); 18–25 vs 26–55-year-olds (1.8 95% CI (1.2–2.8)); lower vs higher income (1.7 95% CI (1.0–2.7); and lower vs higher professional categories (aOR around 1.9). No significant association was found with gender, education level, employment status, living alone, urbanicity, current major depression, daily smoking, weekly heavy drinking, cannabis use, and body mass index.

Conclusions
Most people with suicidal ideation do not attempt suicide. These findings emphasize the need to avoid generic terms such as “suicidality”, and to increase research on suicidal transition to improve prevention and prediction. They may also inform the organization of suicide prevention in the general population.
Society of Surgical Oncology Consensus Statement: Assessing the Evidence for and Utility of Gene Expression Profiling of Primary Cutaneous Melanoma
Authors: Bartlett Edmund K. , O’Donoghue Cristina , Boland Genevieve , Bowles Tawnya , Delman Keith A. , Hieken Tina J. , Moncrieff Marc , Wong Sandra , White Richard L. , Karakousis Giorgos ,   Society of Surgical Oncology Gene Expression Profiling Consensus Statement Work Group
Published: October 2024

Abstract

Introduction
Gene expression profiling (GEP) of primary cutaneous melanoma aims to offer prognostic and predictive information to guide clinical care. Despite limited evidence of clinical utility, these tests are increasingly incorporated into clinical care.

Methods
A panel of melanoma experts from the Society of Surgical Oncology convened to develop recommendations regarding the use of GEP to guide management of patients with melanoma. The use of currently available GEP tests were evaluated in three clinical scenarios: (1) the utility in patient selection for sentinel lymph node biopsy; (2) the utility to guide surveillance; and (3) the utility to inform adjuvant therapy. As a basis for these recommendations, the panel performed a systematic review of the literature, including articles published from January 2012 until August 2023.

Results
After review of 137 articles, 50 met the inclusion criteria. These articles included evidence related to three available GEP tests: 31-GEP, CP-GEP, and 11-GEP. The consensus recommendations were finalized using a modified Delphi process. The panel found that current evidence often fails to account for known clinicopathologic risk factors and lacks high-level data. The panel recognizes that the study of GEP tests is still evolving. The integration of GEP into routine clinical practice for predicting sentinel lymph node status and patient prognosis in melanoma is therefore not currently recommended.

Conclusion
At present, GEP should be considered primarily an investigational tool, ideally used in the context of clinical trials or specialized research settings.
Endogenous Preference for Nonmarket Goods in Carbon Abatement Decisions
Authors: Wang Fangzhi , Liao Hua , Tol Richard S. J. , Ji Changjing 
Published: October 2024

Long-term decisions, such as decisions about carbon abatement, are usually based on the implausible assumption of constant social preference. This paper focuses on a specific case of market and nonmarket goods, and it investigates the optimal climate policy when social preference for them is also changed by climate policy in a seminal climate-economy model: the Dynamic Integrated Model of Climate and the Economy (DICE) model with a single objective to maximize market goods consumption. We amend DICE to study an optimization problem that trades off the values of market and nonmarket goods, considering endogenous preferences. The relative price of non-market goods grows over time because of increases in both relative scarcity and the appreciation that represents the preference of it. As nonmarket goods are increasingly valuable relative to market ones, climate damages on nonmarket goods are increasingly expensive. The social cost of carbon, which aggregated climate impact on both goods, is consequently higher. Because abatement decision affects the valuation of nonmarket goods in the utility function, unlike previous climate-economy models, we solve the model iteratively by taking the obtained abatement rates from the last run as inputs in the current run. The results in baseline calibration advocate a more stringent climate policy, where endogenous social preference to climate policy raises the social cost of carbon further by roughly 12%–18% this century. Moreover, neglecting changing social preference leads to an underestimate of nonmarket goods damages by 15%. Climate policy is self-reinforced if it favors the more expensive consumption good. The proposed method can be applied to other long-term problems with endogenous preferences. Funding: H. Liao appreciates the funding from the National Natural Science Foundation of China [Grants 71925008, 72293603, and 72488101].
Toxoplasmosis infection in an HIV-negative patient presenting with clinical and MRI findings similar to those of multiple sclerosis
Authors: Nurgaliyeva Bayan , Nyssanbayeva Kulman , Choudhary Manish 
Published: October 2024

Toxoplasmosis is a parasitic infection that can present in various clinical forms, ranging from asymptomatic to severe neurological manifestations. The primary sources of infection include undercooked meat, unwashed produce and contact with cat faeces. Toxoplasmosis can lead to encephalitis, particularly in immunocompromised patients, and is often misdiagnosed as other neurological conditions such as multiple sclerosis (MS). We report the case of a 44-year-old male from Almaty, Kazakhstan, who presented with neurological symptoms including headaches, dizziness, diplopia, leg weakness and elevated blood pressure. The patient had a history of consuming undercooked meat, but no prior neurological conditions. Initial magnetic resonance imaging (MRI) revealed demyelinating lesions, leading to a diagnosis of MS. However, high levels of IgG antibodies against Toxoplasma gondii were detected, prompting further testing. A polymerase chain reaction test for toxoplasmosis was negative, but the patient was treated empirically with trimethoprim and sulfamethoxazole for six months. A follow-up MRI showed a significant reduction in brain lesions, and the patient’s symptoms improved.
Photonic Interfaces for Neutral Atom Quantum Computers
Authors: Lukin Mikhail , Grinkemeyer Brandon 
Published: October 2024

We introduce a platform that integrates atom arrays in optical tweezers with a fiber Fabry-Perot cavity, providing an efficient quantum optical interface for neutral atom quantum computers. Leveraging strong atom-cavity coupling, we demonstrate state readout with error detection and novel methods for cavity-mediated entanglement generation.
Full-text article not available; see video presentation
Project Qu-Gov: Exploration of Quantum Technologies for and Inside Governmental Administration
Authors: Muth Oliver 
Published: October 2024

In 2022 Bundesdruckerei started the Project Qu-Gov which includes an overall advising approach of the German Federal ministry of Finance concerning the topics Quantum-Information, Quantum-Communication, Post-Quantum-Security, Quantum-Analytics and the souvereign use of Quantum devices and services. In this lecture we talk about our approach and first results.
Full-text article not available; see video presentation
Photonic Quantum Technologies: From Unravelling Quantum Foundations to Advancing Quantum Integration and Developing Applications in Quantum Networks and Computing.
Authors: Barz Stefanie 
Published: October 2024

I will explore various facets of photonic quantum systems and applications in quantum technologies: quantum interference, a key element in quantum technologies, photonic quantum computing, and both hardware aspects and applications of photonic quantum networks.
Full-text article not available; see video presentation
High prevalence of intestinal schistosomiasis in school-age children in the villages adjacent to Lake Chamo in the southern Rift Valley of Ethiopia
Authors: Ayele Yenenesh , Wegayehu Teklu , Woldeyes Daniel , Massebo Fekadu 
Published: October 2024

Background
The prevalence of intestinal schistosomiasis remains a challenge despite government efforts to eliminate the disease. This study aims to assess the prevalence of intestinal schistosomiasis in school-age children living in the villages surrounding Lake Chamo in southern Rift Valley of Ethiopia.

Methodology/Principal findings
A cross-sectional study was conducted from January to July 2023 in Shele Mela Kebele in Gamo Zone, South Ethiopia. Stool samples were collected from 597 school-age children. A singe Kato-Katz for helminths and formalin-ether concentration technique for protozoan parasites were used to process the samples. The intensity of Schistosoma mansoni infection among school-age children was determined by counting the number of eggs per gram of stool. Of the 597 children screened, 52.3% (95% CI: 48.4.4–56.4) were positive for Schistosoma mansoni. These findings showed that 55% of the infections were light, 30.3% were moderate, and 14.7% were heavy. The mean egg count of S. mansoni parasites was 182.1 eggs per gram. The prevalence of other intestinal parasites (Hymenolopis nana, Ascaris lumbricoides, Hookworm, Taenia species, Giardia lamblia and Entamoeba histolytica) was found to be 7.7% (46/597). The overall prevalence of S. mansoni co-infection with other intestinal parasites was 5.0% (30/597). Specifically, the co-infection rates were 1.5% for A. lumbricoides, 1.3% for H. nana, 1.0% for Taenia species, 0.2% for Hookworm, 0.2% for E. histolytica, and 0.2% for G. lamblia.

Conclusions/Significances
The study showed a high rate of S. mansoni infection among school-age children. This calls for immediate action, such as school-based deworming, to protect these children from the disease and reduce the burden. Further research is needed to understand the transmission of the infection by the intermediate host.
HIV seropositive disclosure and associated factors among adult HIV positive clients in public health facilities in East Wollega Zone, Oromia Regional State, Western Ethiopia
Authors: Fikadu Worku , Dechassa Chala , Desalegn Zelalem , Ewunetu Adisu , Lema Matiyos , Tekle Adisu 
Published: October 2024

Background
Disclosure of HIV-seropositive is important for HIV prevention and maintenance of health for people living with HIV and the community at large. Although HIV seropositive disclosure is mandatory for access to care and treatment, there is a paucity of data in the study setting.

Objective
This study aimed to assess the magnitude of HIV Sero Positive Disclosure and associated factors among adult HIV positive clients in public health facilities in the east wollega zone, Oromia Regional State, Western Ethiopia, in 2023.

Methods
A facility-based cross-sectional study design was conducted among 250 adult HIV-positive clients in public health facilities in East Wollega Zone. Systematic sampling was used to select the study participants. Data were collected from February 1 to April 15, 2023, using a structured, pretested, interviewer-administered questionnaire and reviewing patient cards using a checklist. Data were entered into Epi Data version 3.1 and exported to SPSS version 25 for analysis. Bivariable and multivariable logistic regression analyses were done. In bivariable analyses, variables with a P-value <0.25 were candidates for the multivariable model; in the multivariable model, significant associations were declared at a P-value < 0.05 and reported by an adjusted odds ratio along with a 95% confidence interval.

Results
The magnitude of HIV seropositive disclosure to at least one person was found to be 68.2% (95%CI = 62.5%, 73.9%). HIV seropositive disclosure was significantly associated with being married ((AOR = 5.47, 95%CI: 2.87–10.43), low knowledge level (AOR = 0.095, 95% CI = 0.017–0.54), and perceived community discrimination (AOR = 0.192, 95% CI = 0.050, 0.74).

Conclusion
This study reveals that HIV seropositive disclosure was low among the adult population living in the study area as compared to the other study findings. Disclosure of seropositives was significantly associated with marital status, knowledge level about the importance of disclosure, and perceived discrimination in societies. Healthcare providers and HIV prevention programme planners should provide health education about the importance of HIV disclosure and the stigma against HIV-positive patients by increasing society’s awareness through appropriate channels.
Undernutrition and associated factors among adolescent girls in Diga District, East Wollega Zone, Ethiopia
Authors: Bobo Emebet , Bikila Haile , Muche Mekonen Wandimu , Belete Fite Meseret , Enkossa Ayana Gurmessa , Etafa Werku 
Published: October 2024

Background
Undernutrition is a significant challenge for adolescent girls globally due to biological, social, and cultural factors. The consequences of undernutrition for adolescent girls are extensive, impacting their cognitive abilities, reproductive health, susceptibility to chronic diseases in later life, and the economies of nations. However, there needs to be a more comprehensive understanding of the nutritional status of adolescent girls in the Diga district, Ethiopia.

Objective
This study aimed to assess the prevalence of undernutrition and its associated factors among adolescent girls in the Diga District, East Wollega Zone, Ethiopia.

Methods
The study employed a community-based cross-sectional study design in Diga District, Ethiopia. Data was gathered from 651 study participants using a systematic random sampling technique, from July 10th to August 10th, 2023. Data analysis involved using Epi-Data 4.6 and SPSS version 26 for data entry and statistical analysis, respectively. The Body Mass Index (BMI) and Height-for-age (HFA) Z-score are generated using WHO AnthroPlus version 1.0.4 software. Descriptive statistics and binary logistic regressions were used for data summarization and analysis, with significance testing at a p-value <0.05.

Results
In this study, 16.3% (95% CI: 13.5–19.3) of adolescent girls were stunted, while 18.5% (95% CI: 15.4–21.5) were thin. Lack of access to health and nutrition information (AOR = 3.36, 95% CI: 1.38–8.23), limited crop variety within household’s crops (AOR = 1.66, 95% CI: 1.03–2.65), and household food insecurity (AOR = 2.76, 95% CI: 1.49–5.11) were factors associated with stunting. Poor dietary diversity scores (AOR = 7.52, 95% 95% CI: 2.92–19.39) and household food insecurity (AOR = 3.69, 95% CI: 1.96–6.93) were significantly associated with thinness.

Conclusion
Conclusively, there was a low prevalence of stunting and thinness among adolescent girls in the Diga district, Ethiopia. Interventions aimed at enhancing household-level crop diversity, improving food security, providing adequate health and nutrition information, and promoting income-generating activities for adolescent girls can play a crucial role in improving their access to nutritious foods and healthcare, ultimately leading to better nutritional outcomes.
Defining the molecular response to ischemia-reperfusion injury and remote ischemic preconditioning in human kidney transplantation
Authors: Nordström Johan , Badia-I-Mompel Pau , Witasp Anna , Schwarz Angelina , Evenepoel Pieter , Moor Matthias B. , Wennberg Lars , Saez-Rodriguez Julio , Wernerson Annika , Olauson Hannes 
Published: October 2024

Background
Ischemia-reperfusion injury (IRI) inevitably occurs during kidney transplantation and extended ischemia is associated with delayed graft function and poor outcomes. Remote ischemic preconditioning (RIPC) is a simple, noninvasive procedure aimed at reducing IRI and improving graft function. Experimental studies have implicated the kynurenine pathway as a protective mechanism behind RIPC.

Methods
First, paired biopsies from 11 living kidney donors were analyzed to characterize the acute transcriptomic response to IRI. Second, 16 living kidney donors were subjected to either RIPC (n = 9) or no pretreatment (n = 7) to evaluate the impact of RIPC on the transcriptomic response to IRI. Finally, the effect of RIPC on plasma metabolites was analyzed in 49 healthy subjects.

Results
There was a robust immediate response to IRI in the renal transcriptomes of living-donor kidney transplantation, including activation of the mitogen-activated protein kinase (MAPK) and epidermal growth factor receptor (EGFR) pathways. Preconditioning with RIPC did not significantly alter the transcriptomic response to IRI or the concentration of plasma metabolites.

Conclusions
The present data validate living-donor kidney transplantation as a suitable model for mechanistic studies of IRI in human kidneys. The failure of RIPC to alter transcriptomic responses or metabolites in the kynurenine pathway raises the question of the robustness of the standard procedure used to induce RIPC, and might explain the mixed results in clinical trials evaluating RIPC as a method to attenuate IRI.
The relationship between TMCO1 and CALR in the pathological characteristics of prostate cancer and its effect on the metastasis of prostate cancer cells
Authors: Dong Jingting , Kang Shaosan , Cao Fenghong , Chen Xi , Wang Xiaofei , Wang Lei , Wang Qing , Zhai Yupu 
Published: October 2024

Abstract
Calcium homeostasis is correlated closely with the occurrence and development of various cancers. The role of calcium homeostasis in prostate cancer has remained unclear. The present study aimed to investigate the relationship between transmembrane and crimp-crimp domain 1 (TMCO1) and calreticulin (CALR) in the pathological characteristics of prostate cancer and the mechanism of action on prostate cancer metastasis. Effects of CALR recombinant protein and TMCO1 knockdown on prostate cancer cells were investigated using following methods: cell cloning, Transwell, wound scratch assay, JC-1 assay, Fluo-4 Assay, endoplasmic reticulum (ER) fluorescent probe, mitochondrial fluorescence probe, Western blot and Immunofluorescence. TMCO1 and CALR are overexpressed in prostate cancer and knockdown of TMCO1 significantly inhibited the invasion, migration and cell proliferation. Furthermore, knocking down TMCO1 modulated the intensity of ER probes and mitochondrial fluorescence probes, and affected the levels of intracellular calcium ion and mitochondrial membrane potential. In addition, CALR recombinant protein upregulated the expression of epithelial-mesenchymal transition marker, Vimentin, Conversely, knockout of TMCO1 significantly reduced the expression of CALR and Vimentin. Knockout of TMCO1 can reverse the effect of CALR recombinant protein, elucidating the pivotal roles of TMCO1 and CALR in the regulation of prostate cancer metastasis through modulation of calcium homeostasis.