bluuebunny/crossref_metadata_2025_split huggingface dataset:
Grand challenges in management research: Attributes, achievements, and advancement
Authors: Brammer Stephen , Branicki Layla , Linnenluecke Martina , Smith Tom 
Published: September 2019

Management scholarship is increasingly paying attention to “grand challenges” such as climate and demographic changes, sociopolitical uncertainty, poverty alleviation, and global health improvement. Drawing upon a review of grand challenges research, we highlight the lack of a coherent conceptualization of a “grand challenge” and examine the diversity of the conceptual, policy, and empirical research. We problematize the failure in current research to distinguish between qualitatively different types of grand challenges—in our view, the resolution of different challenges calls for distinct research, policy, and practice approaches. We propose a novel framework that encompasses four distinct forms of grand challenge, situate the existing empirical literature within our framework, describe how the contributions to our special issue advance grand challenges research, and explore implications for future management research that responds to the imperatives of grand challenges. JEL Classification: D81, G01, M14, I18, Q54, Q55, Q56, Q57
Natural mordenite-rich tuff as an alternative for removing textile dyes (Asucryl red): adsorption properties, kinetic and equilibrium studies
Authors: Ayaden Brahim , Benabdeslam Nouara , Bouzidi Nedjima , Mahtout Laila , Bounouala Mohamed , Merabet Djoudi 
Published: September 2019

ABSTRACTThis work examines a tuff from the Tinebdar deposit located in Sidi Aich (east Algeria) for possible use as an alternative material for the adsorption of Asucryl red (a textile dye). Natural tuff represents an economic and environmentally friendly alternative compared to synthetic zeolites. The starting materials were characterized by means of powder X-ray diffraction, Brunauer–Emmett–Teller-specific surface area and pore diameter analysis. Batch experiments were performed and various parameters that have an effect on the adsorption process (i.e. pH, clay amount, contact time and initial concentration) were investigated. The <125 μm grain-size fraction of the tuff contains 45 wt.% mordenite. The adsorption equilibrium was established in 10 min and the adsorption kinetics were better described by the second-order kinetic model. The adsorption isotherm of the results obtained fits better to the Langmuir and Timkin models. The adsorption capacity qt varies from 60 to 70 mg g–1 with temperature increasing from 293 to 333 K. The thermodynamic nature of the adsorption process was determined by calculating ΔH°, ΔS° and ΔG° values. The positive value for ΔH° confirms that the adsorption is endothermic.
Is food supply for shellfish-eating birds in the western Wadden Sea affected by the between-species synchrony in year-to-year fluctuations of bivalve population parameters?
Authors: Beukema J. J. , Dekker R. 
Published: September 2019

Abstract
For a better understanding of functioning and stability of ecosystems, it is important to know to what extent constituent species show similarity in their long-term fluctuation patterns, i.e. whether their numbers and biomass frequently show simultaneous peaks and lows. Synchronic peaks and lows of important species would enhance variability in the functioning of the entire system and might affect its stability. When fluctuation patterns of individual species are largely independent, their peaks and lows would tend to extinguish each other’s effect on overall parameters (such as total zoobenthic biomass), thus promoting system stability. A long-term (46 years) monitoring study of the macrozoobenthos in a large (50 km2) tidal-flat area revealed that the 4 most important bivalve species (3 suspension feeders: Cerastoderma edule, Mytilus edulis, Mya arenaria and 1 deposit/suspension feeder: Limecola (Macoma) balthica) frequently showed peak numbers of their recruits in the same years. The annual growth rates of the three suspension feeding species showed some synchrony as well. Annual survival rates, on the other hand, did not show any synchronization, wiping out the initial synchrony of numbers within less than 2 years. As a result, annual biomass values did not show any positive between-species correlations. Annual amounts of bivalves that are accessible as bird food rarely declined to levels below 5 g AFDW m−2 and showed limited (5 to 10 fold difference between maximal and minimal values) variation. Oystercatchers left the area quicker in late winter and showed increased death rates at very low levels of food supply. Total bivalve bird food did not show any significant long-term trend. However, biomass of Mya arenaria showed an increasing trend and that of Limecola balthica a declining trend.
Genetic parameters for body weight and different definitions of residual feed intake in broiler chickens
Authors: Mebratie Wossenie , Madsen Per , Hawken Rachel , Romé Hélène , Marois Danye , Henshall John , Bovenhuis Henk , Jensen Just 
Published: September 2019

Abstract

Background
The objectives of this study were to (1) simultaneously estimate genetic parameters for BW, feed intake (FI), and body weight gain (Gain) during a FI test in broiler chickens using multi-trait Bayesian analysis; (2) derive phenotypic and genetic residual feed intake (RFI) and estimate genetic parameters of the resulting traits; and (3) compute a Bayesian measure of direct and correlated superiority of a group selected on phenotypic or genetic residual feed intake. A total of 56,649 male and female broiler chickens were measured at one of two ages ($${\text{t}}$$
t
or $${\text{t}} - 6$$

t
-
6

days). BW, FI, and Gain of males and females at the two ages were considered as separate traits, resulting in a 12-trait model. Phenotypic RFI ($${\text{RFI}}_{\text{P}}$$

RFI
P

) and genetic RFI ($${\text{RFI}}_{\text{G}}$$

RFI
G

) were estimated from a conditional distribution of FI given BW and Gain using partial phenotypic and partial genetic regression coefficients, respectively.

Results
Posterior means of heritability for BW, FI and Gain were moderately high and estimates were significantly different between males and females at the same age for all traits. In addition, the genetic correlations between male and female traits at the same age were significantly different from 1, which suggests a sex-by-genotype interaction. Genetic correlations between $${\text{RFI}}_{\text{P}}$$

RFI
P

and $${\text{RFI}}_{\text{G }}$$

RFI

G

were significantly different from 1 at an older age but not at a younger age.

Conclusions
The results of the multivariate Bayesian analyses in this study showed that genetic evaluation for production and feed efficiency traits should take sex and age differences into account to increase accuracy of selection and genetic gain. Moreover, for communicating with stakeholders, it is easier to explain results from selection on $${\text{RFI}}_{\text{G}}$$

RFI
G

than selection on $${\text{RFI}}_{\text{P}}$$

RFI
P

, since $${\text{RFI}}_{\text{G}}$$

RFI
G

is genetically independent of production traits and it explains the efficiency of birds in nutrient utilization independently of energy requirements for production and maintenance.
Impact of aging on obstetric outcomes: defining advanced maternal age in Barcelona
Authors: Claramonte Nieto Marta , Meler Barrabes Eva , Garcia Martínez Sandra , Gutiérrez Prat Mireia , Serra Zantop Bernat 
Published: September 2019

Abstract

Background
Women of advanced maternal age (AMA) are a growing population, with higher obstetric risks. The Mediterranean population has specific characteristics different from other areas. Thus, the objective of this study was to establish a cut-off to define AMA in a selected mediterranean population coming from a tertiary referral private/mutual health hospital in Barcelona.

Methods
Retrospective cohort of euploid singleton pregnancies delivered from January 2007 to June 2017. Main maternal outcomes were: gestational diabetes, preeclampsia, placenta previa, c-section and prolonged hospitalization (≥ 7 days). Main adverse perinatal outcomes were: stillbirth, prematurity, preterm prelabor rupture of membranes, low birth weight, need of admission at a neonatal intensive care unit and perinatal mortality. Adjustment for confounding factors (smoking, previous comorbilities, parity, assisted reproductive techniques (ART) and obesity) was performed.

Results
A total of 25054 pregnancies were included. Mean maternal age was 34.7 ± 4.2 years, with 2807 patients in the group of age between 40 and 44 years (11.2%) and 280 patients ≥45 years (1.1%). Women at AMA had higher incidence of previous comorbilities (compared to the reference group of women < 30 years): prior c-section, chronic hypertension and obesity. In addition, they were more likely to use ART. After adjusting for confounding factors, maternal age was an independent and statistically significant risk factor for gestational diabetes (OR 1.66/2.80/3.14) for ages 30–39, 40–44 and ≥ 45 years respectively, c-section (OR 1.28/2.41/7.27) and placenta previa (OR 2.56/4.83) for ages 40–44 and ≥ 45 years respectively, but not for preeclampsia (neither early-onset nor late-onset). Risk of emergency c-section was only increased in women ≥45 years (OR, 2.03 (95% CI, 1.50–2.74). In the other groups of age, the increase in c-section rate was because of elective indications. Age ≥ 45 years was associated with iatrogenic prematurity < 37 weeks (OR 2.62, 95% CI 1.30–5.27). No other relevant associations between AMA and maternal or neonatal outcomes were found.

Conclusions
Maternal age is an independent risk factor for adverse obstetric outcomes. Age ≥ 40 years was associated to relevant increased risks and reveals to be an adequate cut-off to define AMA in our population.
Targeted Next Generation Sequencing for malaria research in Africa: current status and outlook
Authors:   Plasmodium Diversity Network Africa, Ghansah Anita , Kamau Edwin , Amambua-Ngwa Alfred , Ishengoma Deus S. , Maiga-Ascofare Oumou , Amenga-Etego Lucas , Deme Awa , Yavo William , Randrianarivelojosia Milijaona , Ochola-Oyier Lynette Isabella , Helegbe Gideon Kofi , Bailey Jeffery , Alifrangis Michael , Djimde Abdoulaye 
Published: September 2019

Abstract
Targeted Next Generation Sequencing (TNGS) is an efficient and economical Next Generation Sequencing (NGS) platform and the preferred choice when specific genomic regions are of interest. So far, only institutions located in middle and high-income countries have developed and implemented the technology, however, the efficiency and cost savings, as opposed to more traditional sequencing methodologies (e.g. Sanger sequencing) make the approach potentially well suited for resource-constrained regions as well. In April 2018, scientists from the Plasmodium Diversity Network Africa (PDNA) and collaborators met during the 7th Pan African Multilateral Initiative of Malaria (MIM) conference held in Dakar, Senegal to explore the feasibility of applying TNGS to genetic studies and malaria surveillance in Africa. The group of scientists reviewed the current experience with TNGS platforms in sub-Saharan Africa (SSA) and identified potential roles the technology might play to accelerate malaria research, scientific discoveries and improved public health in SSA. Research funding, infrastructure and human resources were highlighted as challenges that will have to be mitigated to enable African scientists to drive the implementation of TNGS in SSA. Current roles of important stakeholders and strategies to strengthen existing networks to effectively harness this powerful technology for malaria research of public health importance were discussed.
Medulloblastoma rendered susceptible to NK-cell attack by TGFβ neutralization
Authors: Powell Allison B. , Yadavilli Sridevi , Saunders Devin , Van Pelt Stacey , Chorvinsky Elizabeth , Burga Rachel A. , Albihani Shuroug , Hanley Patrick J. , Xu Zhenhua , Pei Yanxin , Yvon Eric S. , Hwang Eugene I. , Bollard Catherine M. , Nazarian Javad , Cruz Conrad Russell Y. 
Published: September 2019

AbstractBackgroundMedulloblastoma (MB), the most common pediatric brain cancer, presents with a poor prognosis in a subset of patients with high risk disease, or at recurrence, where current therapies are ineffective. Cord blood (CB) natural killer (NK) cells may be promising off-the-shelf effector cells for immunotherapy due to their recognition of malignant cells without the need for a known target, ready availability from multiple banks, and their potential to expand exponentially. However, they are currently limited by immune suppressive cytokines secreted in the MB tumor microenvironment including Transforming Growth Factor β (TGF-β). Here, we address this challenge in in vitro models of MB.MethodsCB-derived NK cells were modified to express a dominant negative TGF-β receptor II (DNRII) using retroviral transduction. The ability of transduced CB cells to maintain function in the presence of medulloblastoma-conditioned media was then assessed.ResultsWe observed that the cytotoxic ability of nontransduced CB-NK cells was reduced in the presence of TGF-β-rich, medulloblastoma-conditioned media (21.21 ± 1.19% killing at E:T 5:1 in the absence vs. 14.98 ± 2.11% in the presence of medulloblastoma-conditioned media, n = 8, p = 0.02), but was unaffected in CB-derived DNRII-transduced NK cells (21.11 ± 1.84% killing at E:T 5:1 in the absence vs. 21.81 ± 3.37 in the presence of medulloblastoma-conditioned media, n = 8, p = 0.85. We also observed decreased expression of CCR2 in untransduced NK cells (mean CCR2 MFI 826 ± 117 in untransduced NK + MB supernatant from mean CCR2 MFI 1639.29 ± 215 in no MB supernatant, n = 7, p = 0.0156), but not in the transduced cells. Finally, we observed that CB-derived DNRII-transduced NK cells may protect surrounding immune cells by providing a cytokine sink for TGF-β (decreased TGF-β levels of 610 ± 265 pg/mL in CB-derived DNRII-transduced NK cells vs. 1817 ± 342 pg/mL in untransduced cells; p = 0.008).ConclusionsCB NK cells expressing a TGF-β DNRII may have a functional advantage over unmodified NK cells in the presence of TGF-β-rich MB, warranting further investigation on its potential applications for patients with medulloblastoma.
Personalized prediction of live birth prior to the first in vitro fertilization treatment: a machine learning method
Authors: Qiu Jiahui , Li Pingping , Dong Meng , Xin Xing , Tan Jichun 
Published: September 2019

Abstract

Background
Infertility has become a global health issue with the number of couples seeking in vitro fertilization (IVF) worldwide continuing to rise. Some couples remain childless after several IVF cycles. Women undergoing IVF face greater risks and financial burden. A prediction model to predict the live birth chance prior to the first IVF treatment is needed in clinical practice for patients counselling and shaping expectations.

Methods
Clinical data of 7188 women who underwent their first IVF treatment at the Reproductive Medical Center of Shengjing Hospital of China Medical University during 2014–2018 were retrospectively collected. Machine-learning based models were developed on 70% of the dataset using pre-treatment variables, and prediction performances were evaluated on the remaining 30% using receiver operating characteristic (ROC) analysis and calibration plot. Nested cross-validation was used to make an unbiased estimate of the generalization performance of the machine learning algorithms.

Results
The XGBoost model achieved an area under the ROC curve of 0.73 on the validation dataset and showed the best calibration compared with other machine learning algorithms. Nested cross-validation resulted in an average accuracy score of 0.70 ± 0.003 for the XGBoost model.

Conclusions
A prediction model based on XGBoost was developed using age, AMH, BMI, duration of infertility, previous live birth, previous miscarriage, previous abortion and type of infertility as predictors. This study might be a promising step to provide personalized estimates of the cumulative live birth chance of the first complete IVF cycle before treatment.
Withholding and withdrawing life-support in adults in emergency care: joint position paper from the French Intensive Care Society and French Society of Emergency Medicine
Authors:   For the French Society of Emergency Medicine (Société Française de Médecine d’Urgence, SFMU) and French Intensive Care Society (Société de Réanimation de Langue Française, SRLF), Reignier Jean , Feral-Pierssens Anne-Laure , Boulain Thierry , Carpentier Françoise , Le Borgne Pierrick , Del Nista Denis , Potel Gilles , Dray Sandrine , Hugenschmitt Delphine , Laurent Alexandra , Ricard-Hibon Agnès , Vanderlinden Thierry , Chouihed Tahar 
Published: September 2019

AbstractFor many patients, notably among elderly nursing home residents, no plans about end-of-life decisions and palliative care are made. Consequently, when these patients experience life-threatening events, decisions to withhold or withdraw life-support raise major challenges for emergency healthcare professionals. Emergency department premises are not designed for providing the psychological and technical components of end-of-life care. The continuous inflow of large numbers of patients leaves little time for detailed assessments, and emergency department staff often lack training in end-of-life issues. For prehospital medical teams (in France, the physician-staffed mobile emergency and intensive care units known as SMURs), implementing treatment withholding and withdrawal decisions that may have been made before the acute event is not the main focus. The challenge lies in circumventing the apparent contradiction between the need to make immediate decisions and the requirement to set up a complex treatment project that may lead to treatment withholding and/or withdrawal. Laws and recommendations are of little assistance for making treatment withholding and withdrawal decisions in the emergency setting. The French Intensive Care Society (Société de Réanimation de Langue Française, SRLF) and French Society of Emergency Medicine (Société Française de Médecine d’Urgence, SFMU) tasked a panel of emergency physicians and intensivists with developing a document to serve both as a position paper on life-support withholding and withdrawal in the emergency setting and as a guide for professionals providing emergency care. The task force based its work on the available legislation and recommendations and on a review of published studies.
Best-worst scaling improves measurement of first impressions
Authors: Burton Nichola , Burton Michael , Rigby Dan , Sutherland Clare A. M. , Rhodes Gillian 
Published: September 2019

Abstract
A common goal in psychological research is the measurement of subjective impressions, such as first impressions of faces. These impressions are commonly measured using Likert ratings. Although these ratings are simple to administer, they are associated with response issues that can limit reliability. Here we examine best-worst scaling (BWS), a forced-choice method, as a potential alternative to Likert ratings for measuring participants’ facial first impressions. We find that at the group level, BWS scores correlated almost perfectly with Likert scores, indicating that the two methods measure the same impressions. However, at the individual participant level BWS outperforms Likert ratings, both in terms of ability to predict preferences in a third task, and in terms of test-retest reliability. These benefits highlight the power of BWS, particularly for use in individual differences research.
Reduction of radiation exposure to operating physician and assistant using a real-time auditory feedback dosimeter during femoral artery puncturing: a study on swine model
Authors: Khan Muhammad Umair Ahmad , Yi Byung-Ju 
Published: September 2019

Abstract

Background
Real-time dosimeters may create a relatively safer environment not only for the patient but also for the physician and the assistant as well. We propose the use of a real-time radiation measurement dosimeter having auditory feedback to reduce radiation exposure.

Methods
Radiation dose rates were measured for 30 fluoroscopy-guided puncturing procedures of femoral arteries in swine. Fifteen puncturing procedures were performed with real-time radiation measurement dosimeter having auditory feedback and other 15 were performed without auditory feedback dosimeter by an interventional cardiologist with 10 years of experience.

Results
The left body side of the operating physician (38%, p < 0.001) and assistant (25%, p < 0.001) was more exposed as compared to the right body side. Radiation dose rate to the left hand, left arm and left leg were reduced from 0.96 ± 0.10 to 0.79 ± 0.12 mSv/h (17% reduction, p < 0.001), from 0.11 ± 0.02 to 0.07 ± 0.01 mSv/h (36% reduction, p < 0.001) and from 0.22 ± 0.06 to 0.15 ± 0.02 mSv/h (31% reduction, p < 0.001) with the use of auditory feedback dosimeter, respectively. The mean fluoroscopic time was reduced from 4.8 ± 0.43 min to 4.2 ± 0.53 min (p < 0.001). The success rate of performing arterial puncturing was 100%.

Conclusions
The use of auditory feedback dosimeter resulted in reduction in effective dose. The sound beep alerted the physician from the danger of exposure, and this approach induced awareness and protective mindset to the operating physician and assistant.
The Prevalence of Osteoporosis Tested by Quantitative Computed Tomography in Patients With Different Glucose Tolerances
Authors: Li Yufeng , Zhao Zihou , Wang Liangying , Fu Zuodi , Ji Linong , Wu Xiaohong 
Published: September 2019

Abstract

Aim
The objectives of the present study were to compare bone characteristics with quantitative computed tomography (QCT) and other metabolic factors relevant to bone health in subjects with normal glucose tolerance, impaired glucose tolerance (IGT), and diabetes mellitus (DM) and to evaluate the association of various laboratory factors with bone characteristics qualified by QCT.

Methods
This cross-sectional population-based survey of diabetes and metabolic syndrome was conducted in Pinggu, China. The oral glucose tolerance test was conducted and QCT was tested. The volumetric bone mineral density (vBMD) of lumbar vertebrae 2 through 4 was measured.

Results
Among the 4001 eligible participants, the average age was 47.41 ± 11.86 years. The prevalence of osteoporosis evaluated by QCT was 10.6% in the normal glucose tolerance group, 14.8% in the IGT group, and 16.9% in the DM group. Multivariate linear regression analysis showed that age was negatively associated with vBMD, whereas body mass index and waist-hip ratio were positively associated with vBMD across all participants. However, the levels of hemoglobin A1c, fasting plasma glucose, and postprandial glucose were not associated with vBMD after adjusting for sex, age, systolic and diastolic blood pressure, body mass index, total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, FT4, FT3, thyroid-stimulating hormone, urine albumin-to-creatinine ratio, creatinine, and serum uric acid.

Conclusions
We found that the prevalence of osteoporosis evaluated by QCT was 10.6% in the normal glucose tolerance group, 14.8% in the IGT group, and 16.9% in the DM group. The levels of hemoglobin A1c, fasting plasma glucose, and postprandial glucose were not associated with vBMD after adjusting for metabolic factors in a Chinese sample.