bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dimensionen der Bibliotherapie im historischen Kontext des heilsamen Lesens
Authors: Engelhardt Dietrich 
Published: December 2018

ZusammenfassungSeit der Antike wird der Literatur eine Rolle in medizinischer Therapie und Psychotherapie zugeschrieben. Medizin selbst gilt als Kunst (ars) und nicht nur als Wissenschaft (scientia), auch das Leben mit der Krankheit ist eine Kunst. Das positivistische 19. Jahrhundert führt mit der naturwissenschaftlichen Orientierung zu einer Vernachlässigung; zu neuen Initiativen kommt es in der Gegenwart, mit zunehmender Anerkennung des Beitrags der Literatur und aller Künste für einen gelingenden Umgang mit Krankheit, Schmerz und Tod. Sechs Dimensionen sind von zentraler Bedeutung: Lesen in Gesundheit und Krankheit; Einfluß der unterschiedlichen Krankheiten; Abhängigkeit von der Therapieform; Persönlichkeit des Kranken; Vermittlung des literarischen Textes; Berufsbild des Bibliotherapeuten. Literatur ist aber kein Medikament, kann nicht „verschrieben“ werden; entscheidend ist die empathisch-kommunikative Wechselbeziehung im Dreieck von Therapeut, Patient und Text. Der Erfolg der Bibliotherapie mißt sich an den Auswirkungen auf: Körperbeziehung, Raumbeziehung, Zeitbeziehung, soziale Beziehung, Selbstbeziehung und Weltbeziehung. Literatur als kulturelle Antwort auf Krankheit und Therapie, Patient und Therapeut übersteigt zugleich jede Behandlung im biologischen Sinn, öffnet eine diesseitige Überzeitlichkeit oder immanente Transzendenz, trägt zu einer Medizin als medical humanities bei – menschlich und für Menschen.
Dominance, mode, and individual variation in bilingual speech production and perception
Authors: Piccinini Page , Arvaniti Amalia 
Published: December 2018

AbstractEarly Spanish-English bilinguals and English controls were tested on the production and perception of negative, short-lag, and long-lag Voice Onset Time (VOT), VOT types spanning the Spanish and English phonetic categories: phonologically, negative and short-lag VOT stops are distinct phonemes in Spanish, but realizations of voiced stops in English. Dominance was critical: more English-dominant bilinguals produced more short-lag VOT stops in response to negative VOT stimuli, and were also less accurate than more balanced bilinguals at discriminating negative from short-lag VOT. Bilinguals performed similarly to monolinguals overall, but they produced more negative VOT tokens and shorter short-lag VOT in response to negative VOT. Their productions were also less well correlated with perception and showed more variation between individuals. These results highlight the variable nature of bilingual production and perception, and demonstrate the need to consider language dominance, individual variation, as well as modalities and tasks when studying bilinguals.
Investigating vulnerabilities in grammatical processing of bilinguals
Authors: Pourquié Marie , Lacroix Hugues , Kartushina Natalia 
Published: December 2018

Abstract
Bilinguals show a large gap in their expressive-receptive abilities, in both languages. To date, most studies have examined lexical processing. The current study aimed to assess comprehension and production of verb agreement, i.e., grammatical processing, in bilinguals, and to examine the factors that might modulate them: exposure, age and language-specific morphological complexity. Twenty balanced Basque-Spanish bilinguals (10 adults and 10 children) were assessed on comprehension and production of subject-verb agreement in both languages and object-verb agreement in Basque. Twenty age-matched Spanish-dominant Basque-Spanish bilinguals were assessed in Spanish only. The results revealed a consistent gap in Basque in both children and adults, with an advantage for comprehension. In Spanish, a gap appeared in children only, with an advantage for production. The gap size did not vary with the amount of language exposure but with age and morphological complexity, suggesting that these factors modulate bilinguals’ grammatical processing.
CSHAP: efficient haplotype frequency estimation based on sparse representation
Authors: Zhou Yinsheng , Zhang Han , Yang Yaning 
Published: December 2018

Abstract

Motivation
Estimating haplotype frequencies from genotype data plays an important role in genetic analysis. In silico methods are usually computationally involved since phase information is not available. Due to tight linkage disequilibrium and low recombination rates, the number of haplotypes observed in human populations is far less than all the possibilities. This motivates us to solve the estimation problem by maximizing the sparsity of existing haplotypes. Here, we propose a new algorithm by applying the compressive sensing (CS) theory in the field of signal processing, compressive sensing haplotype inference (CSHAP), to solve the sparse representation of haplotype frequencies based on allele frequencies and between-allele co-variances.

Results
Our proposed approach can handle both individual genotype data and pooled DNA data with hundreds of loci. The CSHAP exhibits the same accuracy compared with the state-of-the-art methods, but runs several orders of magnitude faster. CSHAP can also handle with missing genotype data imputations efficiently.

Availability and implementation
The CSHAP is implemented in R, the source code and the testing datasets are available at http://home.ustc.edu.cn/∼zhouys/CSHAP/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Human Direct Skin Feeding Versus Membrane Feeding to Assess the Mosquitocidal Efficacy of High-Dose Ivermectin (IVERMAL Trial)
Authors: Smit Menno R , Ochomo Eric O , Aljayyoussi Ghaith , Kwambai Titus K , Abong’o Bernard O , Bousema Teun , Waterhouse David , Bayoh Nabie M , Gimnig John E , Samuels Aaron M , Desai Meghna R , Phillips-Howard Penelope A , Kariuki Simon K , Wang Duolao , Ward Stephen A , ter Kuile Feiko O 
Published: December 2018

Abstract

Background
Ivermectin is being considered for mass drug administration for malaria, due to its ability to kill mosquitoes feeding on recently treated individuals. In a recent trial, 3-day courses of 300 and 600 mcg/kg/day were shown to kill Anopheles mosquitoes for at least 28 days post-treatment when fed patients’ venous blood using membrane feeding assays. Direct skin feeding on humans may lead to higher mosquito mortality, as ivermectin capillary concentrations are higher. We compared mosquito mortality following direct skin and membrane feeding.

Methods
We conducted a mosquito feeding study, nested within a randomized, double-blind, placebo-controlled trial of 141 adults with uncomplicated malaria in Kenya, comparing 3 days of ivermectin 300 mcg/kg/day, ivermectin 600 mcg/kg/day, or placebo, all co-administered with 3 days of dihydroartemisinin-piperaquine. On post-treatment day 7, direct skin and membrane feeding assays were conducted using laboratory-reared Anopheles gambiae sensu stricto. Mosquito survival was assessed daily for 28 days post-feeding.

Results
Between July 20, 2015, and May 7, 2016, 69 of 141 patients participated in both direct skin and membrane feeding (placebo, n = 23; 300 mcg/kg/day, n = 24; 600 mcg/kg/day, n = 22). The 14-day post-feeding mortality for mosquitoes fed 7 days post-treatment on blood from pooled patients in both ivermectin arms was similar with direct skin feeding (mosquitoes observed, n = 2941) versus membrane feeding (mosquitoes observed, n = 7380): cumulative mortality (risk ratio 0.99, 95% confidence interval [CI] 0.95–1.03, P = .69) and survival time (hazard ratio 0.96, 95% CI 0.91–1.02, P = .19). Results were consistent by sex, by body mass index, and across the range of ivermectin capillary concentrations studied (0.72–73.9 ng/mL).

Conclusions
Direct skin feeding and membrane feeding on day 7 resulted in similar mosquitocidal effects of ivermectin across a wide range of drug concentrations, suggesting that the mosquitocidal effects seen with membrane feeding accurately reflect those of natural biting. Membrane feeding, which is more patient friendly and ethically acceptable, can likely reliably be used to assess ivermectin’s mosquitocidal efficacy.

Clinical Trials Registration
NCT02511353.
Hybrid versus catheter ablation in patients with persistent and longstanding persistent atrial fibrillation: a systematic review and meta-analysis†
Authors: van der Heijden Claudia A J , Vroomen Mindy , Luermans Justin G , Vos Rein , Crijns Harry J G M , Gelsomino Sandro , La Meir Mark , Pison Laurent , Maesen Bart 
Published: December 2018

SummaryAs the mechanisms underlying persistent atrial fibrillation (AF) are still incompletely understood, a ‘gold standard’ strategy for ablation is lacking. The results of catheter ablation, independent of the ablation strategy applied, are disappointing. Hybrid ablation, combining a thoracoscopic epicardial and transvenous endocardial approach, has shown more favourable outcomes. To date, studies comparing both techniques are lacking. Therefore, we conducted a systematic review and meta-analysis of hybrid versus catheter ablation in patients with persistent or longstanding persistent AF. A systematic literature search of studies reporting on catheter and hybrid ablation of persistent or longstanding persistent AF was performed in the PubMed database. All identified articles were screened and checked for eligibility. A meta-analysis was performed on inter-study heterogeneity and pooled correlation between baseline characteristics, primary and secondary outcomes of hybrid and catheter studies. From the 520 articles identified by the search, 34 articles could be included in the analysis. Hybrid ablation resulted in higher freedom of atrial arrhythmias in patients with persistent and longstanding-persistent AF than catheter ablation (70.7% vs 49.9%, P < 0.001). Although hybrid ablation had a slightly higher complication rate than catheter ablation, overall morbidity and mortality were low. In conclusion, hybrid ablation is more effective than catheter ablation in maintaining the sinus rhythm in patients with persistent or longstanding persistent AF. However, data directly comparing both techniques are lacking, and small, heterogenic, single-arm studies in a random-effects model prevent definite conclusions from being drawn. Therefore, larger randomized controlled trials directly comparing both techniques are needed.
Consultations for gastroenteritis in general practice and out-of-hours services in Norway 2006–15
Authors: Emberland Knut Erik , Wensaas Knut-Arne , Litleskare Sverre , Rortveit Guri 
Published: December 2018

Abstract

Background
Most of the patients with gastroenteritis seeking health care services are managed in primary care; yet, little is known about these consultations. Syndromic-based surveillance of gastrointestinal infections is used in several countries, including Norway.

Aim
To investigate the extent of, and explore characteristics associated with, consultations for gastroenteritis in primary care and to compare consultations in daytime general practice and out-of-hours (OOH) services in Norway.

Design and Setting
Registry-based study using reimbursement claims data from all consultations in general practice and OOH services in Norway over the 10-year period, 2006–15.

Methods
The main outcome variable was whether the consultation took place in general practice or OOH services. Possible associations with patient age and sex, time and use of point-of-care C-reactive protein (CRP) testing and sickness certificate issuing were investigated.

Results
Gastroenteritis consultations (n = 1 281 048) represented 0.9% of all consultations in primary care (n = 140 199 637), of which 84.4% were conducted in general practice and 15.6% in OOH services. Young children and young adults dominated among the patients. Point-of-care CRP testing was used in 36.1% of the consultations. Sickness certificates were issued in 43.6% of consultations with patients in working age. Age-specific time variations in consultation frequencies peaking in winter months were observed.

Conclusions
The proportion of gastroenteritis consultations was higher in the OOH services when compared with daytime general practice. Young children and young adults dominated among the patients. The seasonal variation in consultation frequency is similar to that shown for gastroenteritis caused by norovirus.
Prospective associations of maternal choline status with offspring body composition in the first 5 years of life in two large mother–offspring cohorts: the Southampton Women’s Survey cohort and the Growing Up in Singapore Towards healthy Outcomes cohort
Authors: van Lee Linde , Crozier Sarah R , Aris Izzuddin M , Tint Mya T , Sadananthan Suresh Anand , Michael Navin , Quah Phaik Ling , Robinson Sian M , Inskip Hazel M , Harvey Nicholas C , Barker Mary , Cooper Cyrus , Velan Sendhil S , Lee Yung Seng , Fortier Marielle V , Yap Fabian , Gluckman Peter D , Tan Kok Hian , Shek Lynette P , Chong Yap-Seng , Godfrey Keith M , Chong Mary F F 
Published: December 2018

AbstractBackgroundCholine status has been positively associated with weight and fat mass in animal and human studies. As evidence examining maternal circulating choline concentrations and offspring body composition in human infants/children is lacking, we investigated this in two cohorts.MethodsMaternal choline concentrations were measured in the UK Southampton Women’s Survey (SWS; serum, n = 985, 11 weeks’ gestation) and Singapore Growing Up Towards healthy Outcomes (GUSTO); n = 955, 26–28 weeks’ gestation) mother–offspring cohorts. Offspring anthropometry was measured at birth and up to age 5 years. Body fat mass was determined using dual-energy x-ray absorptiometry at birth and age 4 years for SWS; and using air-displacement plethysmography at birth and age 5 years for GUSTO. Linear-regression analyses were performed, adjusting for confounders.ResultsIn SWS, higher maternal choline concentrations were associated with higher neonatal total body fat mass {β = 0.60 standard deviation [SD]/5 µmol/L maternal choline [95% confidence interval (CI) 0.04–1.16]} and higher subscapular skinfold thickness [β = 0.55 mm/5 µmol/L (95% CI, 0.12–1.00)] at birth. In GUSTO, higher maternal choline concentrations were associated with higher neonatal body mass index-for-age z-score [β = 0.31 SD/5 µmol/L (0.10–0.51)] and higher triceps [β = 0.38 mm/5 µmol/L (95% CI, 0.11–0.65)] and subscapular skinfold thicknesses [β = 0.26 mm/5 µmol/L (95% CI, 0.01–0.50)] at birth. No consistent trends were observed between maternal choline and offspring gain in body mass index, skinfold thicknesses, abdominal circumference, weight, length/height and adiposity measures in later infancy and early childhood.ConclusionOur study provides evidence that maternal circulating choline concentrations during pregnancy are positively associated with offspring BMI, skinfold thicknesses and adiposity at birth, but not with growth and adiposity through infancy and early childhood to the age of 5 years.
Long-time L∞(L2) a posteriori error estimates for fully discrete parabolic problems
Authors: Sutton Oliver J 
Published: December 2018

Abstract
Computable estimates for the error of finite element discretisations of parabolic problems in the $L^{\infty }(0,T; L^2(\varOmega ))$ norm are developed, which exhibit constant effectivities (the ratio of the estimated error to the true error) with respect to the simulation time. These estimates, which are of optimal order, represent a significant advantage for long-time simulations and are derived using energy techniques based on elliptic reconstructions. The effectivities of previous optimal-order error estimates in this norm derived using energy techniques are shown numerically to grow in proportion to either the simulation duration or its square root, a key disadvantage compared with earlier estimators derived using parabolic duality arguments. The new estimates form a continuous family, almost all of which are new, reproducing certain familiar energy-based estimates well suited for short-time simulations and not available through the parabolic duality framework. For clarity, we demonstrate the technique applied to a linear parabolic problem discretised using standard conforming finite element methods in space coupled with backward Euler and Crank–Nicolson time discretisations, although it can be applied much more widely.
An ancillary genomics system to support the return of pharmacogenomic results
Authors: Rasmussen Luke V , Smith Maureen E , Almaraz Federico , Persell Stephen D , Rasmussen-Torvik Laura J , Pacheco Jennifer A , Chisholm Rex L , Christensen Carl , Herr Timothy M , Wehbe Firas H , Starren Justin B 
Published: December 2018

AbstractExisting approaches to managing genetic and genomic test results from external laboratories typically include filing of text reports within the electronic health record, making them unavailable in many cases for clinical decision support. Even when structured computable results are available, the lack of adopted standards requires considerations for processing the results into actionable knowledge, in addition to storage and management of the data. Here, we describe the design and implementation of an ancillary genomics system used to receive and process heterogeneous results from external laboratories, which returns a descriptive phenotype to the electronic health record in support of pharmacogenetic clinical decision support.
Detection of periodicity based on independence tests – IV. Phase distance correlation periodogram for two-dimensional astrometry
Authors: Zucker Shay 
Published: December 2018

ABSTRACT
I present an extension of the phase distance correlation periodogram to two-dimensional astrometric data. I show that this technique is more suitable than previously proposed approaches to detect eccentric Keplerian orbits, and that it overcomes the inherent bias of the joint periodogram to circular orbits. This new technique might prove to be essential in the context of future astrometric space missions such as Theia.
Structural-Level Approaches for HIV Prevention and Care in US Prisons
Authors: Fullilove R. E 
Published: December 2018

Abstract
Given the vast potential to intervene in prison settings, this chapter provides the background and a corresponding case study as to how structural-level approaches might be used to prevent HIV acquisition/transmission in prison settings. A peer-based model that empowers inmates to be the change agents is described. The chapter offers a compelling case that peer education programs created, managed, and administered by incarcerated persons have significant and often unrecognized potential. It begins with an overview of HIV in US prisons, followed by a description of peer education programs and HIV prevention and World AIDS Day in Prison using three correctional facilities as examples. Implications and conclusions close out the chapter.
Homeless Risk Among Post-9/11 Era Veterans
Authors: Metraux Stephen , Smith R. Tyson 
Published: December 2018

Abstract
Media and advocacy outlets have expressed alarm about homelessness among post-9/11–era Veterans, with little systematic research available to evaluate these claims and to offer an empirically based profile of the nature and extent of homelessness. In this chapter, the authors draw on research, media, and advocacy accounts to identify the factors that are particular to homelessness among this most recent cohort of Veterans, with a particular focus on defining military-based factors of this era and broader systemic forces that were formative to Veterans’ experiences after returning to civilian life. These factors, the authors argue, interact to create a set of circumstances that do not appear to currently create substantially elevated rates of homelessness among post-9/11 Veterans but that potentially warrant policy attention and interventions in specific areas, as well as further monitoring of homelessness risk over the cohort’s collective life course.
Homeless Veterans and Use of Information Technology
Authors: McInnes D. Keith , Cutrona Sarah L. 
Published: December 2018

Abstract
Persons experiencing homelessness, including homeless Veterans, increasingly use cell phones, computers, and other digital devices. In this chapter, the authors discuss use of technology by homeless Veterans, exploring ways that technology can facilitate access to information on resources including housing, job opportunities, health care, and personal health management. Also addressed is the role of technology in supporting development and maintenance of social networks and social capital for these marginalized Veterans. There have been several research reports specifically on homeless Veterans’ access to and use of information technologies. One study found that 89% of homeless Veteran survey participants had a cell phone. Like housed cell phone users, homeless Veterans use cell phones to stay in touch with family and friends and to complete specific tasks and transactions. Special challenges exist regarding technology use among homeless Veterans, including loss and theft of phones, keeping phones charged, and affording the service costs. The discussion in this chapter is informed by the Technology Acceptance Model (TAM), which states that perceived ease of use and perceived usefulness affect attitudes toward use, intention to use, and ultimately, actual use in light of contextual, external variables. External variables for homeless Veterans include tenuous living arrangements, significant financial challenges, military culture, diverse experiences during military service, and complex medical and mental health conditions. The chapter concludes by looking at advances in technology that may be beneficial for homeless Veterans and also the challenges, related to technology, that are likely to continue for this population.
What Does It Mean to Live on the Poverty Threshold? Lessons From Reference Budgets
Authors: Goedemé Tim , Penne Tess , Hufkens Tine , Karakitsios Alexandros , Bernát Anikó , Franziskus Anne , Simonovits Bori , Álvarez Elena Carillo , Kanavitsa Eleni , Cussó Parcerisas Irene , Romaní Jordi Riera , Mäkinen Lauri , Matsaganis Manos , Arlotti Marco , Kopasz Marianna , Szivós Péter , Ritakallio Veli-Matti , Kazepov Yuri , Van den Bosch Karel , Storms Bérénice 
Published: December 2018

Abstract
This chapter makes use of the first effort to construct cross-country comparable reference budgets in Europe to show what the large cross-national differences in living standards imply in practice for the adequacy of incomes at the level of the at-risk-of-poverty threshold. The budgets show that, in the poorest EU Member States, even adequate food and housing are barely affordable at the level of the threshold, whereas a decent living standard is much more in reach for those living on the threshold in the richer EU Member States. The reference budgets also suggest that the poverty risk of some groups (for instance, children) is underestimated relative to that of other age groups, while the poverty risk of homeowners is probably relatively overestimated.
A Pan-European Perspective on Low-Income Dynamics in the European Union
Authors: Goedemé Tim , Trindade Lorena Zardo , Vandenbroucke Frank 
Published: December 2018

Abstract
This chapter examines trends at the lower tail of the EU-wide distribution of disposable household incomes. Using EU-SILC data from 2008 to 2014, it compares income levels across countries, after accounting for average price differences, focusing on levels and trends of the EU-wide low-income proportion and the EU-wide low-income gap. The analysis reveals that living standards in the new EU Member States have improved in comparison with the EU-wide median, while living standards in the crisis-hit Southern European countries have deteriorated. This indicates an important change in the composition of the bottom of the pan-European income distribution. It is also observed that no country succeeded in reducing the EU-wide low-income proportion while also reducing the at-risk-of-poverty rate. The results emphasize the need of a dual perspective on solidarity, a national and a pan-European, and the importance of reflecting further on the need of mutual insurance and true solidarity across borders.