bluuebunny/crossref_metadata_2025_split huggingface dataset:
Common Consumer Health-Related Needs in the Pediatric Hospital Setting: Lessons from an Engagement Consultation Service
Authors: Lee Daniel , Cronin Robert , Robinson Jamie , Anders Shilo , Unertl Kim , Kelly Katherine , Hankins Heather , Skeens Ryan , Jackson Gretchen 
Published: August 2018

Background Informed and engaged parents may influence outcomes for childhood illness. Understanding the needs of the caregivers of pediatric patients is a critical first step in promoting engagement in their child's care. In 2014, we developed an Engagement Consultation Service at the Monroe Carell Jr. Children's Hospital at Vanderbilt. This service determines the health-related needs of the caregivers of hospitalized children and makes educational or technology recommendations to meet those needs and support engagement.
Objectives This report describes the most common health-related needs identified in the caregivers of hospitalized pediatric patients and details the recommended interventions to meet those needs.
Methods The most commonly reported consumer health-related needs from our 3-year experience with the Engagement Consultation Service were extracted from consultations notes. Each need was classified by semantic type using a taxonomy of consumer health needs. Typical recommendations for each need and their administration were detailed.
Results The most frequently recognized needs involved communicating with health care providers after discharge, using medical devices, distinguishing between benign and concerning symptoms, knowing what questions to ask providers and remembering them, finding trustworthy sources of information online, understanding disease prognosis, and getting emotional support. A variety of apps, Web sites, printed materials, and online groups were recommended.
Conclusion The parents of hospitalized patients share several common health-related needs that can be addressed with educational and technology interventions. An inpatient Engagement Consultation Service provides a generalizable framework for identifying health-related needs and delivers tools to meet those needs and promote engagement during and after hospitalizations.
Benjamin and Borges
Authors: Moradi Joz Rasool , Pirnajmuddin Hossein 
Published: August 2018

AbstractBorges’ works deconstruct the time lag conceived in the binaries such as the work’s production vs. its criticism, the original text vs. its translation, the source text vs. the derivative nature of the target text, and reality vs. fiction. Benjamin, as Borges’ near contemporary, echoes rather the same idea in his post-Nietzschean philosophy of translation. Focusing on the similarities between the views of Benjamin on translation and those of Borges as reflected in his stories as well as his essays, particularly in his well-received essay on translations ofThousand and One Nightsand in his meta-fictional short story‘Pierre Menard’: Author of the Quixote, this paper aims at bringing the two scholars together in the context of literary translation studies in the postmodern era, where intersemiotic and intertextual collage (in Eco’s terminology) and mimicry bear witness to the claim that translation, like other intertextual enterprises, is neither inferior to the other intertextual undertakings such as writing, nor is it detached from language as post-structurally conceived. Furthermore, another core objective of this study is to show how Borges’‘Menard’heralds and truly represents the translation theories built upon the underlying assumptions of deconstructionism since the 1980s. It is concluded that as far as postmodern and poststructuralist theories are concerned, both Borges’ and Benjamin’s works had predicted the future of literary and translation theories in which the decisive role of translation and translator in the construction of culture and identities cannot be denied.
Beyond health messaging: a behavioural economics approach to increasing self‐selected distance during an acute bout of cycling
Authors: Piepmeier Aaron T. , Etnier Jennifer L. , Fasczewski Kimberly S. 
Published: August 2018

AbstractThe purpose of this study was to explore the effects of the perceived purpose of exercising on the self‐selected distance peddled during an acute cycling task. Participants were randomly assigned to one of three groups (health, wealth, charity). All participants watched a video emphasizing the health benefits of performing at least 30 min of daily exercise. Those in the health group were not provided any additional information. Those in the wealth group were then informed that they would earn money for every two kilometres cycled. Those in the charity group were informed that they would earn money for a charity for every two kilometres cycled. Participants were not given a time/distance limit and were instructed to cycle until they chose to stop. Analyses revealed that participants in the wealth and charity group cycled significantly farther than those in the health group (approximately twice as far). Additionally, a significant sex by group interaction showed that women cycled farther for charity while men cycled farther for wealth. These results suggest that health messages used to increase exercise behaviour may benefit from exploring how paradigms from behavioural economics influence behaviors that have relevance to public health.
Inner functions and zero sets for ℓ^{𝑝}_{𝐴}
Authors: Cheng Raymond , Mashreghi Javad , Ross William 
Published: August 2018

In this paper we characterize the zero sets of functions from

ℓ

A

p

\ell ^{p}_{A}

(the analytic functions on the open unit disk

D

\mathbb {D}

whose Taylor coefficients form an

ℓ
p

\ell ^p

sequence) by developing a concept of an “inner function” modeled by Beurling’s discussion of the Hilbert space

ℓ

A

2

\ell ^{2}_{A}

, the classical Hardy space. The zero set criterion is used to construct families of zero sets which are not covered by classical results. In particular, we give an alternative proof of a result of Vinogradov [Dokl. Akad. Nauk SSSR 160 (1965), pp. 263–266] which says that when

p
>
2

p > 2

, there are zero sets for

ℓ

A

p

\ell ^{p}_{A}

which are not Blaschke sequences.
Cell membrane proteins with high N-glycosylation, high expression and multiple interaction partners are preferred by mammalian viruses as receptors
Authors: Zhang Zheng , Zhu Zhaozhong , Chen Wenjun , Cai Zena , Xu Beibei , Tan Zhiying , Wu Aiping , Ge Xingyi , Guo Xinhong , Tan Zhongyang , Xia Zanxian , Zhu Haizhen , Jiang Taijiao , Peng Yousong 
Published: August 2018

Abstract

Motivation
Receptor mediated entry is the first step for viral infection. However, the question of how viruses select receptors remains unanswered.

Results
Here, by manually curating a high-quality database of 268 pairs of mammalian virus–host receptor interaction, which included 128 unique viral species or sub-species and 119 virus receptors, we found the viral receptors are structurally and functionally diverse, yet they had several common features when compared to other cell membrane proteins: more protein domains, higher level of N-glycosylation, higher ratio of self-interaction and more interaction partners, and higher expression in most tissues of the host. This study could deepen our understanding of virus–receptor interaction.

Availability and implementation
The database of mammalian virus–host receptor interaction is available at http://www.computationalbiology.cn: 5000/viralReceptor.

Supplementary information
Supplementary data are available at Bioinformatics online.
A quantitative map of protein sequence space for the cis-defensin superfamily
Authors: Shafee Thomas , Anderson Marilyn A 
Published: August 2018

Abstract

Motivation
The cis-defensins are a superfamily of small, cationic, cysteine-rich proteins, sharing a common scaffold, but highly divergent sequences and varied functions from host-defence to signalling. Superfamily members are most abundant in plants (with some genomes containing hundreds of members), but are also found across fungi and invertebrates. However, of the thousands of cis-defensin sequences in databases, only have a handful have solved structures or assigned activities. Non-phylogenetic sequence-analysis methods are therefore necessary to use the relationships within the superfamily to classify members, and to predict and engineer functions.

Results
We show that the generation of a quantitative map of sequence space allows these highly divergent sequences to be usefully analyzed. This information-rich technique can identify natural groupings of sequences with similar biophysical properties, detect interpretable covarying properties, and provide information on typical or intermediate sequences for each cluster. The cis-defensin superfamily contains clearly-defined groups, identifiable based on their biophysical properties and motifs. The organization of sequences within this space also provides a foundation of understanding the ancient evolution of the superfamily.

Availability and implementation
A webtool for exploring and querying the space is hosted at TS404.shinyapps.io/DefSpace.

Supplementary information
Supplementary data are available at Bioinformatics online.
DCARS: differential correlation across ranked samples
Authors: Ghazanfar Shila , Strbenac Dario , Ormerod John T , Yang Jean Y H , Patrick Ellis 
Published: August 2018

Abstract

Motivation
Genes act as a system and not in isolation. Thus, it is important to consider coordinated changes of gene expression rather than single genes when investigating biological phenomena such as the aetiology of cancer. We have developed an approach for quantifying how changes in the association between pairs of genes may inform the outcome of interest called Differential Correlation across Ranked Samples (DCARS). Modelling gene correlation across a continuous sample ranking does not require the dichotomisation of samples into two distinct classes and can identify differences in gene correlation across early, mid or late stages of the outcome of interest.

Results
When we evaluated DCARS against the typical Fisher Z-transformation test for differential correlation, as well as a typical approach testing for interaction within a linear model, on real TCGA data, DCARS significantly ranked gene pairs containing known cancer genes more highly across several cancers. Similar results are found with our simulation study. DCARS was applied to 13 cancers datasets in TCGA, revealing several distinct relationships for which survival ranking was found to be associated with a change in correlation between genes. Furthermore, we demonstrated that DCARS can be used in conjunction with network analysis techniques to extract biological meaning from multi-layered and complex data.

Availability and implementation
DCARS R package and sample data are available at https://github.com/shazanfar/DCARS. Publicly available data from The Cancer Genome Atlas (TCGA) was used using the TCGABiolinks R package. Supplementary Files and DCARS R package is available at https://github.com/shazanfar/DCARS.

Supplementary information
Supplementary data are available at Bioinformatics online.
Framing and Foreign Policy—Israel's Response to the Arab Uprisings
Authors: Aran Amnon , Fleischmann Leonie 
Published: August 2018

AbstractThe eruption of the 2010 Arab uprisings has generated a great deal of academic scholarship. However, the foreign policy of Israel, a key power in the Middle East, amid the Arab uprisings, has received limited attention. Furthermore, as we demonstrate, the conventional wisdom purported by the current debate, which is that Israel adopted a “defensive, non-idealist” realist foreign policy posture (Magen 2015, 114) in the wake of the Arab uprisings, is wrong. Rather, utilizing an innovative approach linking foreign policy analysis (FPA) and the literature on framing, we demonstrate that Israel adopted a foreign policy stance of entrenchment. This posture is predicated on peace for peace not territory, reinforcing Israel's military capabilities, and granting limited autonomy to the Palestinians under Israeli occupation. Thus, the article demonstrates how framing can usefully be operationalized to uncover how binary discourse does not merely reflect foreign policy but is, in fact, constitutive of it. We demonstrate that diagnostic and prognostic frames helped to create a direct connection between the images held by a leader, his/her worldview, ideas, perceptions and misperceptions, and foreign policy actions. These frames constituted action-oriented sets of beliefs and meaning that inspired and legitimated certain foreign policy options and instruments while restricting others.
Effectiveness of Boric Acid by Ingestion, But Not by Contact, Against the Common Bed Bug (Hemiptera: Cimicidae)
Authors: Sierras Angela , Wada-Katsumata Ayako , Schal Coby 
Published: August 2018

AbstractBoric acid has been used as an insecticide in the successful control of agricultural, public health and urban pests long before the advent of synthetic organic pesticides. Boric acid products, formulated as dusts, sprays, granular baits, pastes, gels, and liquids, are widely available to consumers and pest management professionals, especially to control pest infestations within homes. Boric acid dust is commonly used against bed bugs (Cimex lectularius L. [Hemiptera: Cimicidae]), but its efficacy has not been demonstrated. We evaluated the efficacy of boric acid as an ingestible and residual contact insecticide on bed bugs, and compared its efficacy on the German cockroach (Blattella germanica L. [Blattodea: Ectobiidae]) which is known to be susceptible to boric acid by both routes. Dose–response studies of 0–5% boric acid in blood demonstrated that ingested boric acid caused rapid mortality at concentrations of ≥2%, and even 0.5% and 1% boric acid caused 100% mortality, albeit at a slower time course. In contrast, bed bugs survived contact with high concentrations of boric acid dust. Smaller boric acid particles did not increase mortality of either unfed or recently fed bed bugs. The same boric acid products were effective at causing mortality of German cockroaches by both contact and ingestion. We thus conclude that although boric acid is an excellent candidate active ingredient for an ingestible bait formulation, residual applications of dust or spray would be ineffective in bed bug interventions.
All-cause mortality in relation to changes in relative blood volume during hemodialysis
Authors: Preciado Priscila , Zhang Hanjie , Thijssen Stephan , Kooman Jeroen P , van der Sande Frank M , Kotanko Peter 
Published: August 2018

Abstract

Background
Relative blood volume (RBV) monitoring is widely used in hemodialysis (HD) patients, yet the association between intradialytic RBV and mortality is unknown.

Methods
Intradialytic RBV was recorded once/min during a 6-month baseline period; all-cause mortality was noted during follow-up. RBV at 1, 2 and 3 h into HD served as a predictor of all-cause mortality during follow-up. We employed Kaplan–Meier analysis, univariate and adjusted Cox proportional hazards models for survival analysis.

Results
We studied 842 patients. During follow-up (median 30.8 months), 249 patients (29.6%) died. The following hourly RBV ranges were associated with improved survival: first hour, 93–96% [hazard ratio (HR) 0.58 (95% confidence interval (CI) 0.42–0.79)]; second hour, 89–94% [HR 0.54 (95% CI 0.39–0.75)]; third hour, 86–92% [HR 0.46 (95% CI 0.33–0.65)]. In about one-third of patients the RBV was within these ranges and in two-thirds it was above. Subgroup analysis by median age (≤/> 61 years), sex, race (white/nonwhite), predialysis systolic blood pressure (SBP; ≤/> 130 mmHg) and median interdialytic weight gain (≤/> 2.3 kg) showed comparable favorable RBV ranges. Patients with a 3-h RBV between 86 and 92% were younger, had higher ultrafiltration volumes and rates, similar intradialytic average and nadir SBPs and hypotension rates, lower postdialysis SBP and a lower prevalence of congestive heart failure when compared with patients with an RBV >92%. In the multivariate Cox analysis, RBV ranges remained independent and significant outcome predictors.

Conclusion
Specific hourly intradialytic RBV ranges are associated with lower all-cause mortality in chronic HD patients.
Effect of Environmental Temperature on Serum Sodium Level in Hospitalized Non-critically Ill Children
Authors: Sakornyutthadej Natee , Poomthavorn Preamrudee , Mahachoklertwattana Pat 
Published: August 2018

AbstractBackgroundIntravenous hypotonic fluid administered in children is associated with an increased risk of developing hyponatremia. This finding has been reported from temperate countries where climate is relatively cold. But whether this risk also occurs in tropical countries has not been elucidated.ObjectiveThe objective of this study was to determine the relationship between environmental temperature and serum sodium in non-critically ill children.MethodsA retrospective study.ResultsA total of 1061 hospitalized children were enrolled. Incidences of hyponatremia were not different between patients who received isotonic and hypotonic fluids (29% vs. 31%). Subgroup analysis showed a trend of higher incidence of hyponatremia in patients who received hypotonic fluid than isotonic fluid only in patients admitted to the air-conditioned wards (29% vs. 21%, p = 0.08).ConclusionChildren admitted to the air-conditioned wards who received hypotonic fluid seemed to carry a higher risk of developing hyponatremia than those admitted to the non-air-conditioned ward.
FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence
Authors: Latorre Eva , Ostler Elizabeth L. , Faragher Richard G. A. , Harries Lorna W. 
Published: August 2018

ABSTRACTCellular plasticity is a key facet of cellular homeostasis requiring correct temporal and spatial patterns of alternative splicing. Splicing factors, which orchestrate this process, demonstrate age‐related dysregulation of expression; they are emerging as potential influences on aging and longevity. The upstream drivers of these alterations are still unclear but may involve aberrant cellular signaling. We compared the phosphorylation status of proteins in multiple signaling pathways in early and late passage human primary fibroblasts. We then assessed the impact of chemical inhibition or targeted knockdown of direct downstream targets of the ERK and AKT pathways on splicing factor expression, cellular senescence, and proliferation kinetics in senescent primary human fibroblasts. Components of the ERK and AKT signaling pathways demonstrated altered activation during cellular aging. Inhibition of AKT and ERK pathways led to up‐regulation of splicing factor expression, reduction in senescent cell load, and partial reversal of multiple cellular senescence phenotypes in a dose‐dependent manner. Furthermore, targeted knockdown of the genes encoding the downstream targets FOXO1 or ETV6 was sufficient to mimic these observations. Our results suggest that age‐associated dysregulation of splicing factor expression and cellular senescence may derive in part from altered activity of ERK and AKT signaling and may act in part through the ETV6 and FOXO1 transcription factors. Targeting the activity of downstream effectors of ERK and AKT may therefore represent promising targets for future therapeutic intervention.—Latorre, E., Ostler, E. L., Faragher, R. G. A., Harries, L. W. FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence. FASEB J. 33, 1086–1097 (2019). www.fasebj.org
Novel systemic drugs in treatment of atopic dermatitis: results from phase II and phase III studies published in 2017/2018
Authors: Werfel Thomas 
Published: August 2018

Purpose of review
The present review will give an update of recently published clinical studies on novel systemic treatment approaches in atopic dermatitis.

Recent findings
Until 2017 immunosuppressive drugs such as cyclosporine had to be used in atopic dermatitis when the disease could not sufficiently be treated with topical drugs. Several new substances specifically targeting inflammation in atopic dermatitis are currently studied. In 2017, dupilumab was approved in the United States and in Europe for first-line biologic treatment of moderate to severe atopic dermatitis in adults. The antibody blocks a subunit of the interleukin (IL)-4 and IL-13 receptor, thus inhibiting effects of two key cytokines in type 2 polarized inflammation. In addition to the studies on dupilumab recent clinical investigations on the effects on anti-IL-13 (lebrikizumab, tralokinumab), anti-IL-31 receptor (nemolizumab), anti-IL-22 (fezakinumab), and on small molecules targeting the histamine-4-receptor (ZPL389) and the Janus kinase inhibitor baricitinib have been published as full papers in the last 2 years.

Summary
A couple of promising novel therapeutical targets have recently been investigated and published in clinical trials on atopic dermatitis.
Remooring: A Qualitative Focus Group Exploration of How Educators Maintain Identity in a Sea of Competing Demands
Authors: Jauregui Joshua , O’Sullivan Patricia , Kalishman Summers , Nishimura Holly , Robins Lynne 
Published: August 2018

Purpose
Longitudinal faculty development programs (LFDPs) are communities of practice (CoPs) that support development of participants’ educator identity (EID). This study explored how program graduates negotiated their newly formed EIDs among competing identities and demands in academic medicine.

Method
In this multicenter, cross-sectional, qualitative study, graduates of two LFDP cohorts (one and five years post graduation) were invited in 2015 to participate in a one-hour, cohort-specific focus group. The focus group included questions about views of themselves as educators, experiences of transition out of the LFDP, and sustainability of their EID following program participation. Researchers analyzed transcripts using Wenger’s CoP and Tajfel’s social identity theories to guide interpretation of findings.

Results
Thirty-seven graduates, 17 from one year and 20 from five years post graduation, participated in eight focus groups. They described developing a new EID in their LFDP CoPs. Three major themes emerged: context, agency, and identity. A push–pull relationship among these themes influenced faculty members’ EID trajectory over time. Graduates described feeling unmoored from their LFDP community after graduation and relied on individual agency to remoor their new identities to supports in the larger institutional context.

Conclusions
LFDP graduation represented a transition point. Graduates found it challenging to lose supports from their time-limited CoP and remoor their EIDs to workplace supports. Remooring required individual agency and external support and affirmation. Faculty development programs must be designed with transition periods and sustainability in mind to ensure that participants and institutions can benefit from their transformative effects over time.