bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stretchable Transparent Conductive Films from Long Carbon Nanotube Metals
Authors: Wang Peng , Peng Zhiwei , Li Muxiao , Wang YuHuang 
Published: August 2018

AbstractFlexible transparent conductors are an enabling component for large‐area flexible displays, wearable electronics, and implantable medical sensors that can wrap around and move with the body. However, conventional conductive materials decay quickly under tensile strain, posing a significant hurdle for functional flexible devices. Here, we show that high electrical conductivity, mechanical stretchability, and optical transparency can be simultaneously attained by compositing long metallic double‐walled carbon nanotubes with a polydimethylsiloxane substrate. When stretched to 100% tensile strain, thin films incorporating these long nanotubes (≈3.2 µm on average) achieve a record high conductivity of 3316 S cm−1 at 100% tensile strain and 85% optical transmittance, which is 194 times higher than that of short nanotube controls (≈0.8 µm on average). Moreover, the high conductivity can withstand more than 1000 repeated stretch‐release cycles (switching between 100% and 0% strain) with a retention approaching 96%, whereas the short nanotube controls exhibit only 10%. Mechanistic studies reveal that long tubes can bridge the microscale gaps generated during stretching, thereby maintaining high electrical conductivity. When mounted on human joints, this elastic transparent conductor can accommodate large motions to provide stable, high current output. These results point to transparent conductors capable of attaining high electrical conductivity and optical transmittance under mechanical strain to allow large shape changes that may take place in the operation and use of flexible electronics.
An exploratory study on the evolution of Android malware quality
Authors: Mercaldo Francesco , Di Sorbo Andrea , Visaggio Corrado Aaron , Cimitile Aniello , Martinelli Fabio 
Published: August 2018

AbstractIn the context of software engineering, product software quality measures how well a software artifact is designed and coded. Software products must satisfy nonfunctional properties (eg, reliability, usability, understandability, and maintainability), in order to make maintenance and evolution sustainable in the long period. Software evolution is an issue of interest for the malware writers, too, for 2 reasons. First, to evade detection with the minimum effort, malware writers use to produce “variants,” which are obtained by applying little changes to existing malware. Morevoer, recent studies demonstrated that malware is increasingly improving evasion strategies and infection mechanisms and is using more and more complex payloads. This suggests that malware writers are devoting relevant efforts and skills for producing high‐quality software. For this reason, we wonder whether malware writers are devoting effort to improve the structural quality of their code, too, as it happens in the development of goodware. To investigate this question, we (1) characterize a dataset containing about 20 000 Android applications, divided into goodware and malware ones, relying on the Android API version they require, and (2) compute software quality metrics, divided into 4 categories (ie, dimensional, complexity, object‐oriented, and Android‐oriented metrics) for apps belonging to each population. We then identify evolution trends of these metrics in malware and goodware. The results of our study demonstrate that goodware and malicious applications exhibit similar evolution trends for some of the quality indicators, suggesting that malware writers care about the overall quality of their code. Code quality could be considered an indirect measure of how many and how fast variants of existing malware will be released in the wild.
A middleware solution for integrating and exploring IoT and HPC capabilities
Authors: de Souza Cimino Leonardo , de Resende José Estevão Eugênio , Silva Lucas Henrique Moreira , Rocha Samuel Queiroz Souza , de Oliveira Correia Matheus , Monteiro Guilherme Souza , de Souza Fernandes Gabriel Natã , da Silva Moreira Renan , de Silva Junior Guilherme , Santos Matheus Inácio Batista , Aquino Andre Luiz Lins , Almeida André Luís Barroso , de Castro Lima Joubert 
Published: August 2018

SummaryEven with the considerable advances in the development of middleware solutions, there is still a substantial gap in Internet of Things (IoT) and high‐performance computing (HPC) integration. It is not possible to expose services such as processing, storage, sensing, security, context awareness, and actuating in a unified manner with the existing middleware solutions. The consequence is the utilization of several solutions with their particularities, thus requiring different skills. Besides that, the users have to solve the integration and all heterogeneity issues. To reduce the gap between IoT and HPC technologies, we present the JavaCá&Lá (JCL), a middleware used to help the implementation of distributed user‐applications classified as IoT‐HPC. This ubiquity is possible because JCL incorporates (1) a single application programming interface to program different device categories; (2) the support for different programming models; (3) the interoperability of sensing, processing, storage, and actuating services; (4) the integration with MQTT technology; and (5) security, context awareness, and actions services introduced through JCL application programming interface. Experimental evaluations demonstrated that JCL scales when doing the IoT‐HPC services. Additionally, we identify that customized JCL deployments become an alternative when Java‐Android and vice‐versa code conversion is necessary. The MQTT brokers usually are faster than JCL HashMap sensing storage, but they do not perform distributed, so they cannot handle a huge amount of sensing data. Finally, a short example for monitoring moving objects exemplifies JCL facilities for IoT‐HPC development.
Shear behaviour of girders with trapezoidal corrugated steel webs – an experimental study
Authors: Zhang Boshan , Chen Weizhen , Xu Jun 
Published: August 2018

AbstractScherverhalten von Balken mit Stegen aus Trapezblech – eine experimentelle Studie. In Forschungsarbeiten zum Scherverhalten von Balken mit Trapezblechstegen kommen gegenwärtig üblicherweise numerische Analysen mit der Finite‐Elemente‐Methode und kleinmaßstäbliche Versuche zur Anwendung. Allerdings können diese beiden Methoden kaum die Auswirkungen von Konstruktionsfehlern in realen Tragwerken berücksichtigen. Außerdem wurden in den meisten Studien an Balken mit Trapezblechstegen Doppel‐T‐Träger mit senkrechten Stegen und dünnen Flanschen als Forschungsobjekte verwendet, die ungeeignet sind, Balken mit geneigten Stegen oder Verbundgurten zu repräsentieren. Deshalb wurde ein Balken mit Trapezblechsteg und geneigten Flanschen im Originalmaßstab geprüft. Untersucht wurden der Versagensmodus und die Scherfestigkeit des Balkens. Die Ergebnisse zeigen, dass die Querkrafttragfähigkeit der Flansche nicht vernachlässigt werden darf. Die Out‐of‐Plane‐Verformung beginnt aufgrund anfänglicher geometrischer Unvollkommenheiten mit der Belastung des Stegs. Knickversagen tritt in denjenigen Bereichen auf, in denen die Out‐of‐Plane‐Verformung am schnellsten fortschreitet.
Instandsetzung und Ertüchtigung des Mülheimer Brückenzuges in Köln
Authors: Kratzke Bastian , Uphoff Henning , Hanke Silja 
Published: August 2018

AbstractHerrn Dipl.‐Ing., Dr.‐Ing. E. h. Reiner Saul zur Vollendung des 80. Lebensjahres gewidmetDer Mülheimer Brückenzug, bestehend aus Deichbrücke, Flutbrücke, Strombrücke und Rechtsrheinischer Rampe, ist die nördlichste innerstädtische Rheinquerung in Köln. Die Querung ist nicht nur für den motorisierten Individualverkehr von großer Bedeutung, sondern überführt auch Geh‐ und Radwege sowie zwei Straßenbahnlinien der Kölner Verkehrsbetriebe (KVB). Nach nun mehr als 60‐jähriger Standzeit sind Instandsetzungs‐ und Ertüchtigungsmaßnahmen erforderlich, um den Brückenzug trotz gestiegener Verkehrszahlen weiter nutzen zu können. Je nach Zustand der Bestandsbauwerke müssen angepasste Lösungen gefunden werden; die Strombrücke wird instandgesetzt und über ihre ursprüngliche Tragfähigkeit verstärkt, die Flutbrücke wird instandgesetzt und erhält neue Gehweg‐Kragarme, für die Deichbrücke und die Rechtsrheinische Rampe sind Ersatzneubauten erforderlich.In diesem Beitrag wird auf die Arbeiten an den drei Stahlbrücken (Deich‐, Flut‐ und Strombrücke) eingegangen, wobei der Fokus auf der als erdverankerte Hängebrücke ausgeführten Strombrücke liegt.
Sanierung und Erweiterung Haus des Landtags von Baden‐Württemberg, Tragwerksplanung
Authors: Hahn Michael , Madeja Kilian , Bacher Adelheid , Maier Markus 
Published: August 2018

AbstractHerrn Dipl.‐Ing., Dr.‐Ing. E. h. Reiner Saul zur Vollendung des 80. Lebensjahres gewidmetDas Gebäude des Landesparlaments Baden‐Württemberg erscheint nach einer mehrjährigen Umbauphase äußerlich nahezu unverändert, lediglich der größtenteils unterirdische Anbau des neuen Bürger‐ und Medienzentrums (BuMZ) wird mit seiner Agora im Akademiegarten als Veränderung erkannt. Allerdings sind die Veränderungen innerhalb des Landtagsgebäudes umso deutlicher sichtbar, insbesondere die Ergebnisse der Eingriffe in die tragende Konstruktion des Plenarsaales. Dieser war in seiner ursprünglichen Konzeption seiner Erbauer ein hermetisch durch weitspannende Stahlbetonbauteile begrenztes Raumvolumen ohne Tageslichtbezug, wie auch ohne Möglichkeit einer Sichtbeziehung nach draußen oder drinnen. In einem eigens dafür ausgelobten Architektenwettbewerb sollten die Parlamentarier endlich „Licht und Sicht” in und aus dem Plenarsaal erhalten.Die dafür umgesetzten baulichen Eingriffe in das Tragwerk des unter Denkmalschutz stehenden Hauses des Landtags (HdL) von Baden‐Württemberg sowie die umfangreichen Vorkehrungen und Überlegungen zur Sicherung der Bauzustände sind Hauptthema dieses Beitrags.Darüber hinaus werden die Konstruktion der innovativen Lichtdecke im Plenarsaal sowie die Ganzglas‐Aufzugseinhausung am Zugang des BuMZ beschrieben. Beides sind bauaufsichtlich nicht geregelte, neuartige Sonderkonstruktionen und erforderten Einzelfall‐Zustimmungen (ZiE) der zuständigen Baubehörde.Bei den beschriebenen baulichen Eingriffen handelt es sich im Wesentlichen um die Schaffung großer Wandöffnungen in den Plenarsaalwänden für Transparenz und Sichtbeziehungen, die Herstellung großer Öffnungen in die Plenarsaaldecke für Tageslichtbezug und Lichtlenkelemente, den Umbau des Plenarsaalbodens für eine stufenfreie Ausbaufläche im Plenarsaal, die Herstellung eines Zugangs im Untergeschoss des Landtaggebäudes zum neuen BuMZ sowie den Einbau eines neuen Aufzugsschachtes im Landtagsgebäude für den barrierefreien Zugang zum BuMZ.
Der Ersatzneubau der Sinntalbrücke
Authors: Anistoroaiei Christian , Heymel Ulrich , Jung Rolf 
Published: August 2018

AbstractHerrn Dipl.‐Ing., Dr.‐Ing. E. h. Reiner Saul zur Vollendung seines 80. Lebensjahres gewidmetDie neue Sinntalbrücke im Zuge der BAB A7 wurde als Ersatzneubau direkt neben der alten Brücke errichtet. Die insgesamt 755 m lange Brücke überspannt das Tal mit 8 Feldern mit Spannweiten von 59 bis 107 m in bis zu 45 m Höhe. Die Herstellung der leichten Stahlkonstruktion erfolgte im Taktschiebeverfahren. Die Betonfahrbahnplatte wurde im Pilgerschrittverfahren hergestellt. Dieser Aufsatz behandelt den Sonderentwurf einer wirtschaftlichen und eleganten Stahlverbundbrücke sowie die wesentlichen Schritte und Besonderheiten zur Herstellung des Bauwerkes.
Active tugger line force control for single blade installation
Authors: Ren Zhengru , Jiang Zhiyu , Gao Zhen , Skjetne Roger 
Published: August 2018

AbstractSingle blade installation is one of the methods for installing large wind turbine blades at an offshore site. During this installation, each blade is lifted by the main crane from the deck of an installation vessel or a transportation barge with blade root approaching the hub. The blade root is then bolted to the hub. The final mating phase is critical and requires high precision. Tugger lines from the crane boom are connected to the suspended blade to reduce pendulum motions. The entire process is typically completed without active tugger line force control. Due to wind‐induced blade loads, strict requirement on installation precision, and the limitations imposed by the lifting equipment, the single blade installation operations are subject to weather constraints. Therefore, developing techniques to reduce the blade motions and consequently shorten the installation time is desired. In this paper, an active control scheme is proposed to control the tugger line forces acting on a blade during the final installation stage before mating. A simplified three degree‐of‐freedom blade installation model is developed for the control design. An extended Kalman filter is used to estimate the blade motions and wind velocities. Feedback linearization and pole placement techniques are applied for the design of the controller. Simulations under turbulent wind conditions are conducted to verify the active control scheme, which effectively reduces the blade root motions in the wind direction.
Unconventional RNA‐binding proteins step into the virus–host battlefront
Authors: Garcia‐Moreno Manuel , Järvelin Aino I. , Castello Alfredo 
Published: August 2018

The crucial participation of cellular RNA‐binding proteins (RBPs) in virtually all steps of virus infection has been known for decades. However, most of the studies characterizing this phenomenon have focused on well‐established RBPs harboring classical RNA‐binding domains (RBDs). Recent proteome‐wide approaches have greatly expanded the census of RBPs, discovering hundreds of proteins that interact with RNA through unconventional RBDs. These domains include protein–protein interaction platforms, enzymatic cores, and intrinsically disordered regions. Here, we compared the experimentally determined census of RBPs to gene ontology terms and literature, finding that 472 proteins have previous links with viruses. We discuss what these proteins are and what their roles in infection might be. We also review some of the pioneering examples of unorthodox RBPs whose RNA‐binding activity has been shown to be critical for virus infection. Finally, we highlight the potential of these proteins for host‐based therapies against viruses.This article is categorized under:

RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
RNA in Disease and Development > RNA in Disease
RNA Interactions with Proteins and Other Molecules > RNA–Protein Complexes
Assessment of the Correlation Between Preoperative and Immediate Postoperative Gastric Volume and Weight Loss After Sleeve Gastrectomy Using Computed Tomography Volumetry
Authors: Elbanna Hosam , Emile Sameh , El‐Hawary Galal El‐Sayed , Abdelsalam Noha , Zaytoun Hossam Abdelhafiz , Elkaffas Haitham , Ghanem Ahmed 
Published: August 2018

AbstractBackgroundLaparoscopic sleeve gastrectomy (LSG) has achieved excellent results in treatment of morbid obesity. The present study aimed to evaluate the impact of the preoperative gastric volume, volume of the remaining gastric pouch, and volume of the resected stomach on weight loss after LSG.MethodsPatients with morbid obesity who underwent LSG were investigated by CT volumetry before and 1 week after LSG to measure the volume of the stomach before and after the procedure, and the volume of the resected stomach was also calculated. The percentage of excess weight loss (EWL) and decrease in body mass index (BMI) at 6 months postoperatively were measured and correlated with preoperative and postoperative gastric volumes.ResultsForty‐seven patients (44 females) were included to the study. A significant decrease in the gastric volume and BMI after LSG was noted. Preoperative gastric volume was positively correlated with preoperative BMI (r = 0.723, p < 0.00001) but not correlated with %EWL at 6 months. The volume of the remaining gastric pouch was positively correlated with BMI at 6 months postoperatively (r = 0.597, p < 0.00001) and negatively correlated with %EWL (r = −0.7495, p < 0.00001). The correlation between the size of resected stomach and %EWL was statistically insignificant, yet the mean percentage of the resected stomach was directly correlated to %EWL.ConclusionThe preoperative volume of the stomach was positively correlated with baseline BMI, but not correlated with %EWL. The size of the remaining gastric pouch and the percentage of the resected stomach had significant impact on %EWL after LSG.
EU pharmacovigilance regulatory requirements of anticancer biosimilar monoclonal antibodies
Authors: Francescon Sara , Fornasier Giulia , Baldo Paolo 
Published: August 2018

AbstractAn increasing number of innovative oncology monoclonal antibodies (mAbs) have been introduced into the global market, and biosimilar versions have now also been approved in Europe. Being complex to develop and difficult to manufacture, the biosimilar is a drug similar but not identical in physicochemical characteristics, efficacy, and safety to an original biological drug already approved in the European Union, for which marketing exclusivity rights have expired. Generally, the safety monitoring of biosimilars follows the same requirements that apply to all biologicals, even if specific pharmacovigilance measures exist and some of them are still being debated. The manufacturing process, immunogenicity, traceability, and extrapolation of indication are keywords which may impact on the achievement of additional knowledge about the safety of a biosimilar mAb. In this article, we aim to discuss elements that play a central role in the pharmacovigilance legislation of biosimilar mAbs.
Pharmacovigilance workflow in Europe and Italy and pharmacovigilance terminology
Authors: Baldo Paolo , Francescon Sara , Fornasier Giulia 
Published: August 2018

AbstractThe terminology used in pharmacovigilance can cause confusion, because there are similar terms that describe different phenomena (e.g. adverse reactions, adverse drug reactions, and side effects). Incorrect use of terminology can have negative effects on the reporting of adverse drug reactions and on the interpretation of these reports. To explain the most common terms used in pharmacovigilance, this article first describes the pharmacovigilance workflow process in the European Union and, as an example, in Italy. Then, the article reviews common pharmacovigilance terms.
Melatonin and Comorbidities in Children with Autism Spectrum Disorder
Authors: Gagnon Katia , Godbout Roger 
Published: August 2018

AbstractPurpose of ReviewMelatonin is used to treat sleep difficulties associated with autism spectrum disorder (ASD). There are growing evidence that melatonin could have an effect on other symptoms than sleep, such as anxiety, depression, pain, and gastrointestinal dysfunctions. Interestingly, these symptoms frequently are found as comorbid conditions in individuals with ASD. We aimed to highlight the potential effect of melatonin on these symptoms.Recent FindingsAnimal and human studies show that melatonin reduces anxiety. Regarding the effect of melatonin on pain, animal studies are promising, but results remain heterogeneous in humans. Both animal and human studies have found that melatonin can have a positive effect on gastrointestinal dysfunction.SummaryMelatonin has the potential to act on a wide variety of symptoms associated with ASD. However, other than sleep difficulties, no studies exist on melatonin as a treatment for ASD comorbid conditions. Such investigations should be on the research agenda because melatonin could improve a multitude of ASD comorbidities and, consequently, improve well-being.
Changes to sleep‐wake behaviors are associated with trajectories of pubertal timing and tempo of secondary sex characteristics☆
Authors: Foley Joan E. , Ram Nilam , Susman Elizabeth J. , Weinraub Marsha 
Published: August 2018

ABSTRACTWe examined relations between sleep‐wake behaviors and pubertal development from age 8.5 through 15.5 years in a US‐based sample of 488 boys (75% White) and 478 girls (78% White). Applying conditional nonlinear growth models to 7‐waves of longitudinal data, we examined how sleep‐wake behaviors are related to individual differences in the developmental timing and tempo of secondary sex characteristics. For girls, results supported the hypothesis that circadian changes in bedtimes, wake times, sleep duration, and eveningness preference were uniquely related to development of discrete aspects of secondary sex characteristics. For boys, the hypothesis was generally not supported. Different endocrine systems related to discrete secondary sex characteristics may be responsible for more relations between sleep and pubic hair development than for breast or genital development. Further research into associations between adrenarche and sleep during puberty may help researchers understand more about the origins and timing of adolescent sleep changes.
Asset supply networks in humanitarian operations: A combined empirical‐simulation approach
Authors: Stauffer Jon M. , Pedraza‐Martinez Alfonso J. , Yan Lu (Lucy) , Van Wassenhove Luk N. 
Published: August 2018

AbstractInternational humanitarian organizations (IHOs) respond to mega disasters while maintaining development programs in the rest of the world (ROW). This means an IHO's asset supply network must perform the challenging task of supporting a fast disaster response while simultaneously maintaining cost‐effective ROW development programs. We study how supply network asset flows are impacted during a mega disaster response and find that resource fluidity, the capability to reallocate resources quickly, impacts both mega disaster and ROW program asset flows within these supply networks. Using data from a large IHO's response to a mega disaster and econometric models, we find a dependency between ROW asset flow and mega disaster asset flow in IHOs with resource fluidity. As mega disaster flow increases, there is a decrease in hub‐to‐hub ROW asset flows and an increase in other ROW asset flows. This is contrary to most humanitarian operations research, which typically assumes independent asset flows. Because of resource fluidity, the combination of these flows does not compromise ROW operations. We use these empirical results to feed a simulation analysis that extends our research to IHOs without resource fluidity and provides actionable insights for varying types of IHOs in various demand scenarios. Simulation insights illustrate that resource fluidity impacts IHO asset supply network costs and optimal configurations.