bluuebunny/crossref_metadata_2025_split huggingface dataset:
Localized Amino Acid Enrichment Analysis as a Tool for Understanding Protein Extremophilicity
Authors: Hill Elliot , Hill Avery , Voisin Elena , Byrd Amber , Schoeffler Allyn 
Published: November 2024

ABSTRACTSequence conservation analyses offer us a powerful glimpse of natural selection at work. Standard tools for measuring sequence conservation report conservation as a function of a specific location in a multiple sequence alignment and have proven indispensable in identifying highly constrained features such as active site residues. The advent of large‐scale genomic sequencing efforts allows researchers to expand this paradigm and investigate more nuanced relationships between sequence and function. Here, we present a simple tool (SWiLoDD: Sliding Window Localized Differentiation Detection) that allows researchers to analyze local, rather than site‐specific, conservation using a sliding window approach. Our tool accepts multiple sequence alignments partitioned based on a biological differentiator and returns alignment position‐based, localized differential enrichment metrics for amino acids of choice. We present two case studies of this analysis in action: local‐but‐diffuse glycine enrichments in the ATPase subunits of thermophilic and psychrophilic bacterial gyrase homologs, and ligand‐ and interface‐specific amino acid enrichments in halophilic bacterial crotonyl‐CoA carboxylases/reductases. Though we have described examples of extremophilic bacterial proteins in this study, our tool may be used to investigate any set of homologous sequences from which sub‐groups can be meaningfully partitioned. Our results suggest that investigating differential localized conservation in partitioned MSAs will expand our understanding of how sequence conservation and protein function are connected.
Experiences of Losing and Re‐Establishing a ‘Sense of Place’: Insights From Forced Resettlement in Myanmar
Authors: Cornish Gillian E. 
Published: November 2024

ABSTRACTForced resettlement, the process of intentionally displacing and moving people from one location to another, increases impoverishment risks and creates severe and long‐lasting economic and psycho‐socio‐cultural impacts. While these impacts are well established, there is comparatively much less research about ‘loss of place’ after displacement when people are disconnected from a space or spaces that are meaningful to them. Therefore, this paper seeks to address this gap through empirical research on the experiences of residents who were displaced and relocated to an outer township in Yangon, Myanmar, 25 years after the resettlement event. The study examines what it means to lose a sense of place after forced resettlement, and how despite the disorientating impacts of displacement, individuals actively worked to re‐establish social and physical connections over time. The paper outlines how displaced residents developed and implemented strategies to re‐establish their sense of place and rebuild their community. It finds that multiple levels of strategies were developed—at individual, household, and community scales—to restore social connections and adapt to a new environment. These findings contribute to a deeper understanding of place attachment and community rebuilding, particularly in contexts where displacement is driven by urban development, climate change, or state interventions.
Quantitative pulmonary perfusion in acute pulmonary embolism and chronic thromboembolic pulmonary hypertension
Authors: Hansen Jacob V. , Poulsen Mette W. , Nielsen‐Kudsk Jens E. , Kalra Mannudeep K. , Lyhne Mads D. , Andersen Asger 
Published: November 2024

AbstractCurrent methods for quantifying perfusion from computed tomography pulmonary angiography (CTPA) often rely on semi‐quantitative scoring systems and requires an experienced evaluator. Few studies report on absolute quantitative variables derived from the images, and the methods are varied with mixed results. Dual‐energy CTPA (DE‐CTPA) enables automatic quantification of lung and lobar perfusion with minimal user interaction by utilizing machine learning based software. We aimed to evaluate differences in DE‐CTPA derived quantitative perfusion variables between patients with acute pulmonary embolism (PE) and chronic thromboembolic pulmonary hypertension (CTEPH). This retrospective, single‐center, observational study included 162 adult patients diagnosed with PE (n = 81) or CTEPH (n = 81) and scanned using dual‐energy CT between 2020 and 2023. Mann–Whitney U tests and permutational analysis of variance (PERMANOVA) were used for comparative analyses. We found whole lung perfusion blood volume to be lower (p < 0.001) in PE patients (median 3399 mL [2554, 4284]) than in CTEPH patients (median 4094 mL [3397, 4818]). The same was observed at single lung and lobar level. PERMANOVA encompassing all perfusion variables showed a difference between the two groups (F‐statistic = 13.3, p = 0.002). Utilizing logistic regression, right and left lower lobe perfusion blood volume showed some ability to differentiate between PE and CTEPH with area under the receiver operation characteristics curve values of 0.71 (95% CI: 0.56; 0.84) and 0.72 (95% CI: 0.56; 0.86). Pulmonary perfusion is lower in patients with PE than patients with CTEPH, highlighted by differences in DECT‐derived perfusion blood volume. Quantitative perfusion variables might be useful to differentiate between the two diseases.
Delta‐like ligand 4 inhibitor drug treatment induces pulmonary hypertension in cancer clinical trials
Authors: Besse Casandra E. , Winicki Nolan M. , Puerta Cristian , Hernandez Moises , Yuan Jason X.‐J. , Thistlethwaite Patricia A. 
Published: November 2024

AbstractDelta‐like ligand 4 (DLL‐4) inhibitor drugs are an emerging cancer treatment. In clinical trials for solid organ malignancies, intravenous administration of monoclonal antibodies that inhibit DLL‐4 is associated with development of pulmonary hypertension, in the absence of left ventricular dysfunction. Analysis of 13 clinical trials showed that pulmonary hypertension is a complication of DLL‐4 inhibition.
Robust Shared Control With Stable Contact Servoing for Enhanced Object Transportation by Telerobotic Bimanual Mobile Manipulators
Authors: Teng Tao , Wu Xi , Li Zhihao , Caldwell Darwin , Chen Fei 
Published: November 2024

ABSTRACTBimanual mobile manipulation significantly enhances the capabilities of field robots that interact with diverse dynamic environments and expands the range of possible manipulation actions. This paper introduces a robust shared control architecture for remote manipulation of the Collaborative Dual‐arm Robot Manipulator (CURI), aimed at stable object transportation. Given that stable contact is pivotal for successful object transportation, our focus is on stabilizing the contact between the robot end‐effectors and the object using a contact servoing strategy. To maintain stable contact, it is essential that the contact wrenches consistently stay within the predefined friction cones throughout the task. We propose a novel shared control strategy to stabilize the contact using the contact parameterization model. This model formulates the contact stability manifold using a set of unconstrained reparameterized variables through a bijective mapping function, ensuring that the controller derived from these unconstrained reparameterized variables consistently maintains contact stability. The efficacy of the proposed approach is convincingly demonstrated through a series of experiments involving representative bimanual transportation tasks within a logistics context. Both theoretical analysis and experimental validations confirm that our proposed control strategy not only ensures the stable transportation of objects by CURI but also substantially enhances the overall robustness of the shared control system.
Estimation and analysis of vegetation parameters for the water cloud model
Authors: Qin Xiangdong , Pang Zhiguo , Lu Jingxuan 
Published: November 2024

AbstractThe Water Cloud Model (WCM) plays a crucial role in active microwave soil moisture inversion applications. Empirical parameters are important factors affecting the accuracy of WCM simulation, but the current evaluation of empirical parameters only considers the forward simulation process, and insufficient consideration is given to the model inversion problem. This study proposes a new estimation method for vegetation parameters in the WCM by combining the soil backscattering model and the objective function. The effectiveness of the method is then verified using measured data. Simultaneously, this study also analyzes the factors influencing the evaluation of vegetation parameters in the WCM, resulting in the following conclusions. First, blindly utilizing vegetation parameters recommended by previous model studies is not advisable. To ensure the accuracy of the simulation, it is necessary to adjust the vegetation parameters appropriately. Second, to ensure the ability of the WCM solving both forward and inverse problems, it is advisable to consider both soil backscatter and surface backscatter simulations in the construction of the cost function. Third, soil backscatter simulations have an impact on the solution of vegetation parameters, and more accurate soil scattering models provide a better representation of the modeled vegetation. This study presents a dependable method for resolving the vegetation parameters of the WCM, thereby offering a valuable reference for the application of the model in surface parameter inversion research.
Integrating social vulnerability to flood risk assessment in Metro Manila
Authors: Dulawan Judy Marie T. , Imamura Yoshiyuki , Amaguchi Hideo 
Published: November 2024

AbstractThis study applied the interaction of social vulnerability and hazard to assess flood risk in three urbanized areas within the Pasig‐Marikina‐Laguna‐Lake catchment: Manila, Marikina, and Parañaque in Metro Manila, Philippines. This study examined risk patterns across different flood return periods (5, 50, and 100 years) in these urban river environments and provided both city‐wide and localized risk assessments. The social vulnerability to flood index (SVFI) was calculated using socioeconomic indicators, while the hazard index was derived from flood depth categories. Results show that city‐level risk indices are low to moderate, with Marikina consistently having the highest risk, followed by Manila and Parañaque. However, localized assessments reveal high‐risk areas within cities, with Manila being the most vulnerable to frequent floods (5‐year return period) and Marikina to less frequent but extreme events (50‐ and 100‐year return periods). Parañaque maintains the lowest risk profile across all scenarios. This study highlights the importance of considering both citywide trends and localized high‐risk areas in flood risk management. It provides valuable insights for disaster management planners and policymakers, enabling the development of targeted strategies for sustainable urban river management and flood risk reduction in rapidly urbanizing river systems. The methodology presented applies to other urban areas that face similar flood risks.
Folic Acid‐Mediated Reduction‐Sensitive Curcumin Prodrug Enhances the Delivery Performance of Curcumin in Liver Cancer Cells
Authors: Lin Yang , Liang Ju , Wu Wenlan , Zhang Yunyun , Yan Fuqing 
Published: November 2024

AbstractIn order to improve the delivery performance of curcumin (CUR) in liver cancer cells, we prepared a targeted and reduction‐sensitive prodrug, folic acid‐polyethylene glycol‐disulfide bond‐curcumin (FA‐PEG‐SS‐CUR). The synthesis involved the conjugation of CUR with NH2‐PEG‐NH2 through a disulfide bond, followed by the connection of CUR‐SS‐PEG‐NH2 to FA‐COOH via acylation. The resultant FA‐PEG‐SS‐CUR prodrug self‐assembled into nano micelles in aqueous solutions, displaying excellent dispersibility with an approximate particle size of 119 nm. In vitro drug release studies demonstrated the sensitivity of FA‐PEG‐SS‐CUR to glutathione (GSH), displaying sustained release performance. After 72 h, FA‐PEG‐SS‐CUR exhibited a drug release rate of 38% at low GSH concentration and 59% at high GSH concentration. Notably, FA‐PEG‐SS‐CUR micelles exhibited favorable biocompatibility. The hemolysis rate resulting from co‐incubation with red blood cells remained below 3%. Furthermore, cytotoxicity experiments unveiled the substantial cytotoxicity of FA‐PEG‐SS‐CUR micelles against HepG2 tumor cells. Cellular uptake studies confirmed the greater internalization of FA‐PEG‐SS‐CUR by HepG2 cells compared to the non‐targeted PEG‐SS‐CUR. The findings highlight the potential of FA‐PEG‐SS‐CUR as an ideal drug delivery system for CUR due to its facile synthesis and strong self‐assembly performance.
Ferrocenyl Aminocresols Display Multimodal Activity Against Triple‐Negative Breast Cancer Cells In Vitro
Authors: Mhlanga Richwell , Mbaba Mziyanda , Tonui Ronald , Edkins Adrienne L. , Khanye Setshaba D. , de la Mare Jo‐Anne 
Published: November 2024

AbstractTriple‐negative breast cancer (TNBC) lacks expression of the oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2/neu), has an aggressive tumor phenotype, shows only a partial response to chemotherapy, and lacks clinically established targeted therapies. Therefore, there is a need to develop more effective drugs for the treatment of TNBC. The ferrocenyl benzoxazine and α‐aminocresols class of compounds gave a potential source of multimodal inhibitors of cancer based on previous studies. In this study, a set of ferrocenyl benzoxazines and α‐aminocresols were screened and characterized as potential inhibitors of TNBC in vitro. A panel of 11 compounds was screened for selective cytotoxicity to cancer cells over normal cell equivalents. Focusing on the previously proposed modes of action of their building blocks, α‐aminocresols 3a and 3b exhibited significant DNA binding capabilities and caused robust DNA damage in TNBC cells. In addition, both compounds exhibited significant ROS generation capability; however, introducing a ROS quencher in a cell viability assay only partially rescued the cells from the cytotoxicity effects of the α‐aminocresols. This, together with the observation that compounds 3a and 3b triggered significant protein aggregation in HCC1806 cells, supports a mixed mode of action for these compounds.
A Mixed‐Pure Planar Heterojunction Structure of Active Layers for Efficient Sequential Blade‐Coating Organic Solar Cells
Authors: Wang Yilin , Tang Yabing , Ouyang Yanni , Wu Weiwei , Patterson Acacia , Alqahtani Obaid , Melody Tanner , Zhou Ke , Lu Guanghao , Min Jie , Zhang Chunfeng , Yan Han , Fan Qunping , Jiang Long , Collins Brian A. , Ma Wei 
Published: November 2024

AbstractPrecise modulating the vertical structure of active layers to boost charge transfer is an effective way to achieve high power conversion efficiencies (PCEs) in organic solar cells (OSCs). Herein, efficient OSCs with a well‐controlled vertical structure are realized by a rapid film‐forming method combining low boiling point solvent and the sequential blade‐coating (SBC) technology. The results of grazing incident wide‐angle X‐ray scattering measurement show that the vertical component distribution is varied by changing the processing solvent. Novel characterization technique such as tilt resonant soft X‐ray scattering is used to test the vertical structure of the films, demonstrating the dichloromethane (DCM)‐processed film is truly planar heterojunction. The devices with chloroform (CF) processed upper layer show an increased mixed phase region compared to these devices with toluene (TL) or ‐DCM‐, which is beneficial for improving charge generation and achieving a superior PCE of 17.36%. Despite significant morphological varies, the DCM‐processed devices perform slightly lower PCE of 16.66%, which is the highest value in truly planar heterojunction devices, demonstrating higher morphological tolerance. This work proposes a solvent‐regulating method to optimize the vertical structure of active layers through SBC technology, and provides a practical guidance for the optimization of the active‐layer microstructure.
Interfacial Electric Field Enhanced Free‐Standing VO2/rGO Aerogel Anode with Ultra High Mass Energy Density for Aqueous Ammonium Ion Battery
Authors: Gong Jia'ni , Bai Pengfei , Zhang Yifu , Zhou Zhenhua , Wang Qiushi , Lv Haifeng , Hu Tao , Wu Xiaojun , Meng Changgong 
Published: November 2024

AbstractAqueous batteries have become a promising means of energy storage due to its environmental friendliness. Nevertheless, it often exhibits limited energy density that hinder their application. Considering that ammonium ion (NH4+) has a low mass and a small hydration radius, aqueous ammonium ion batteries (AAIBs) are expected to solve the problem of low energy density. Herein, we obtain Vanadium dioxide/reduced graphene oxide aerogel (VOGA) by in‐situ growth of VO2 on the graphene surface for interfacial electric field enhanced AAIBs to achieve high mass energy density. The VOGA free‐standing electrode achieves a specific capacity of up to 655 mA g−1 at a current density of 0.5 A g−1. And the mass energy density of the VOGA.
Fe3O4@Pectin@Acetamide for Magnetic Solid Phase Extraction of Some Parabens in Cosmetic Samples and Their Quantification by High‐Performance Liquid Chromatography‐Ultraviolet Detection
Authors: Nikbakhsh Naghmeh , Ghani Milad , Maleki Behrooz 
Published: November 2024

ABSTRACTIn this project, the in‐situ formation of magnetic nanoparticles modified with pectin and acetamide was presented and used as a sorbent in the magnetic solid‐phase extraction method. The synthesis of the magnetic sorbent was studied by various characterization methods. The sorbent was employed for the microextraction of four model analytes including methyl paraben, ethyl paraben, propyl paraben, and butyl paraben. The separation and measurement of the extracted compounds were done by high‐performance liquid chromatography‐ultraviolet detection. In order to achieve the best extraction condition, factors affecting the extraction efficiency were investigated and optimized using response surface methodology. In the obtained optimized condition, the following parameters were achieved: limits of detection: 0.16–0.28 µg/L, limits of quantification: 0.49–0.92 µg/L, and intra‐ and inter‐day relative standard deviations: 1.2%–6.6% and 1.6%–4.8%, respectively. The linear dynamic ranges of the method for methyl paraben, ethyl paraben, butyl paraben, and propyl paraben were 1–200, 0.5–500, 1–500, and 1–500 µg/L, respectively. In order to investigate the effectiveness of the method, the proposed magnetic nanosorbent was used to measure the desired parabens in cosmetic samples. The results showed good accuracy and precision of the developed method for the determination of trace amounts of target analytes.
Ultrasound assessment of lymph nodes for staging of gynecological cancer: consensus opinion on terminology and examination technique
Authors: Fischerova D. , Gatti E. , Culcasi C. , Ng Z. , Szabó G. , Zanchi L. , Burgetova A. , Nanka O. , Gambino G. , Kadajari M. R. , Garganese G. ,   Collaborators
Published: November 2024

ABSTRACTThe lymphatic pathway is an important route of metastasis in gynecological malignancy. Therefore, the examination of lymph nodes is an essential part of the ultrasound evaluation in patients with known or suspected gynecological malignancy. The lymph nodes most frequently involved in gynecological malignancy (apart from vulvar cancer) are parietal (retroperitoneal) and visceral abdominopelvic lymph nodes. In advanced disease, more distant lymph‐node regions, such as the inguinal, axillary and supraclavicular lymph nodes, can also be involved. The standardized description of lymph nodes has been published previously by the Vulvar International Tumor Analysis (VITA) collaborative group. Herein, a collaborative group of gynecologists and gynecological oncologists with extensive ultrasound experience presents a systematic methodology for ultrasonographic lymph‐node assessment performed as part of the locoregional and distant work‐up to assess the extent of gynecological malignancy. The aim of this consensus opinion is also to describe the anatomical classification and drainage pathways of the lymphatic system as relevant to the gynecological organs. © 2024 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Factors affecting marriage and pregnancy/childbirth among women physicians in Japan
Authors: Kawase Kazumi , Adachi Tomoko , Nagoshi Sumiko , Kido Michiko , Nomura Kyoko 
Published: November 2024

AbstractBackgroundPrevious studies have not elucidated the factors affecting marriage and pregnancy/childbirth. This study identifies whether work characteristics and conditions affect marriage and pregnancy/childbirth among women physicians.MethodsThis nationwide survey was conducted on women members of three major Japanese medical societies: internal medicine, obstetrics and gynecology, and surgery.ResultsA total of 7747 women participated in this study. Although the mean age at marriage was the same, the age at the first childbirth in all specialties, especially in surgery, was significantly higher than that for the general Japanese population. In addition, being in a junior position, being board‐certified, and working in a workplace other than a university hospital were positively associated with the experience of pregnancy/childbirth, whereas working hours showed no impact.ConclusionsWe should change the mindset regarding pregnancy/childbirth and build effective strategies in academic institutions to improve the environment for safer pregnancy/childbirth while advancing careers.
Properties of Eco-Cement Blocks Made with Polymer Wastes and Graphene
Authors: Calderón Verónica , Arroyo Raquel , Alía Cristina , Garijo Lucía , González-Moreno Sara 
Published: November 2024

Abstract
The inclusion of polyurethane wastes as recycled and reusable materials to replace variable amounts of aggregates is interesting in the production of new construction materials due to their final properties. In this research, the effects of waste polymer replace by sand (25%) and graphene oxide on mortars (0.5, 1, 1.5, 2, 2.5 y 3% with respect to the cement) have been investigated. To maintain and even improve the final properties, graphene oxide modify aspect as thermal conductivity and electrical properties, water behavior, mechanical properties and final contribution to fire.
Optimization of Tire Rubber-Concrete Core Materials for Application in New Sandwich-Structured Cementitious Composites
Authors: Sambucci Matteo , Gullo Giulia , Valente Marco 
Published: November 2024

Abstract
Implementing tire rubber-concrete mixtures to produce sandwich-structured cementitious composites can represent an attractive route in the perspective of lightweight design, energy efficiency, and sustainability for the building and construction industry. This work deals with a DOE multi-response optimization study on rubber-concrete mixes designed with different proportions of fine and coarse rubber aggregates to achieve the best formulation to be applied in the manufacturing of cementitious sandwich composites. The “sand-free” concrete mixture made up of 70% of rubber powder and 30% of rubber granules was optimal in terms of mechanical properties, physical characteristics, and thermo-acoustic insulation behavior. Sandwich-structured composite incorporating the optimum mix as a core layer showed significant improvement in terms of flexural performance over the monolithic rubberized materials and strength value in the range of RILEM “class II” lightweight construction materials.