bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH ORIENTASI KEWIRAUSAHAAN DAN INOVASI PRODUK TERHADAP KEUNGGULAN BERSAING (Studi Kasus pada Sentra Susu Lembang)
Authors: Yustisia Iva 
Published: June 2019

The Effect Of Entrepreneurial Orientation and Product Innovation To Competitive Advantages (Study Case on Sentra Susu Lembang), under the guidance of Dr. Dwi Raeni Santy. SE., M.Si In running a business course, companies are required to be able to produce a quality product that can be consumed by any among consumers , of course, produce a quality product will affect the competition . Where to produce a quality product means it can gain a competitive advantage .This study aims to determine Entrepreneurial Orientation, Product Innovation that influences on the Competitive Advantages in the Industrial Center of milk Lembang partially and simultaneously.The method that is used in this research is descriptive method verification. The unit of analysis in this study is Entrepreneurs who are in the Industrial Center of milk Lembang Government in total 35 entrepreneurs. The test statistic that is used is the calculation of Pearson correlation, path analysis, the coefficient of determination, hypothesis testing, where the testing is done using the help of IBM SPSS application program 20 for Windows Lisrel.The results showed that Entrepreneurial Orientation in the are in the Industrial Center of milk Lembang significantly Product Innovation as independent variables and Competitive Advantages as dependent variables. In correlation calculations showed a strong relationship between Entrepreneurial Orientation with the Competitive Advantages. Entrepreneurial Orientation and the Competitive Advantages have a positive correlation, means that if Entrepreneurial Orientation is good, it will increase Competitive Advantages to be achieved by the Industrial Center of milk Lembang, if the that Entrepreneurial Orientation is not good, it will decrease the Competitive Advantages in the the Industrial Center of milk Lembang.
PENGARUH KOMPETENSI TERHADAP KINERJA KARYAWAN (Studi di PT. Telekomunikasi Indonesia Tbk Witel Bandung)
Authors: Soetrisno Annisa Putri , Gilang Alini 
Published: June 2019

Penelitian ini dilakukan pada PT. Telekomunikasi Indonesia Tbk Witel Bandung dengan tujuan untuk mengetahui pengaruh kompetensi terhadap kinerja karyawan. Penelitian ini merupakan penelitian kuantitatif dengan metode deskriftif – kausal.Teknik pengumpulan data yang digunakan adalah dengan cara menyebarkan kuesioner dengan menggunakan penelitian sampel berjumlah 63 responden dan menggunakan metode teknik simple random sampling, dimana pengambilan anggota sampel dan populasi diambil secara acak tanpa melihat yang berstrata secara proposional didalam populasi itu dengan metode regresi linier sederhana.Berdasarkan hasil penelitian, dapat disimpulkan bahwa kompetensi mempunyai pengaruh positif dan signifikan terhadap kinerja karyawan pada PT. Telekomunikasi Indonesia Tbk Witel Bandung. Dari Koefisien Determinasi (R Square) menunjukkan nilai sebesar 0,510 atau sebesar 51%, artinya nilai ini menunjukkan bahwa variabel kompetensi mempunyai pengaruh terhadap variabel kinerja karyawan sebesar 51% dan sisanya 49% dipengaruhi variabel lain yang tidak diteliti dalam penelitian ini. Kata kunci: Competence, Employee Performance, Human Resources
Actualités et questionnements théorico-cliniques à propos de l’incongruence de genre chez l’enfant et de la parentalité
Authors: Marchand Jean-Baptiste 
Published: June 2019

Alors que les premiers cas d’incongruence de genre chez l’adulte remontent au début du xx e siècle, le cas particulier de l’incongruence de genre chez l’enfant connaît actuellement d’importants changements constituant une véritable mutation du phénomène. Afin d’exposer et de mieux comprendre ce changement, dans un premier temps, cet article présentera les travaux théoriques et/ou cliniques pouvant être considérés comme incontournables sur ce sujet, à savoir les travaux de Stoller, de Butler et de Laplanche. Ensuite seront abordés le changement de paradigme du syndrome transsexuel à la santé transgenre et les oppositions entre l’approche « prudente » et l’approche gender affirmative . Enfin, dans le but d’illustrer ces éléments, l’article présentera le cas de Marcia, mère de trois enfants dont George, le petit dernier, présente une incongruence de genre.
La solidarité comme moyen de Gestion des Ressources Humaines dans les Très Petites Entreprises (TPE) sénégalaises : vers un modèle local plus adapté
Authors: Simen Serge F. , Ebene Nkoa Diane 
Published: June 2019

L’objet de cet article est de comprendre comment les dirigeants des Très Petites Entreprises (TPE) africaines mobilisent les valeurs culturelles de solidarité d’une part, et en quoi ces valeurs culturelles très prisées en Afrique peuvent constituer un modèle de GRH susceptible d’influer les attitudes des salariés d’autre part. Nous appuyant sur le cas du Sénégal en particulier, les analyses effectuées, à partir d’entretiens semi-directifs menés auprès de dix TPE, ont fait ressortir l’existence des pratiques de RH fortement ancrées dans la logique de solidarité. La solidarité peut ainsi s’observer dans les TPE sénégalaises tant sur le plan social (activités sociales et communautaires) que sur le plan de la rémunération, du recrutement, de la formation ou encore de la communication. Ainsi, il devient possible pour un dirigeant de TPE d’agir sur les ressorts culturels, tels que la solidarité, chez ses collaborateurs, pour promouvoir des méthodes de GRH particulièrement innovantes. Nous tentons de penser la production d’une GRH adaptée aux valeurs et cultures africaines.
La dynamique de Leibniz est-elle compatible avec sa monadologie ?
Authors: Garber Daniel 
Published: June 2019

La dynamique de Leibniz, comme programme d’une science de la force, comportait à son commencement une métaphysique du corps. Quand ce programme vit le jour, à la fin des années 1670, Leibniz soutint que sa science de la force nécessitait la réhabilitation des formes substantielles. Mais à la même époque, l’intérêt de Leibniz pour les véritables unités en tant que constituants ultimes du monde le conduisit à poser le principe d’un monde de substances corporelles, entités faites unes en vertu d’une forme substantielle. Au début des années 1680, il semblait ainsi y avoir deux chemins convergents vers une même métaphysique, la réhabilitation de la forme substantielle. Au fil des ans, ces deux voies métaphysiques évoluèrent. Au milieu des années 1690, à la forme substantielle, comprise comme force active, la métaphysique dynamique ajouta la matière première, comprise comme forme passive. Parallèlement, les unités composant le monde évoluèrent des substances corporelles aux monades, substances non étendues, semblables à l’esprit et constituants ultimes des choses. Je soutiens que, lorsque cela se produisit, il n’était plus évident que ces deux représentations métaphysiques soient encore cohérentes : la métaphysique dynamique, fondée sur la force, et la métaphysique de l’unité, entendue désormais en termes de monades, semblaient de plus en plus incompatibles.
Des objets de luxe oriental
Authors: Girardier Sandrine 
Published: June 2019

L’article apporte un éclairage sur le contexte productif et marchand de l’horlogerie du dernier quart du xviiie siècle et du début du xixe siècle, à travers l’exemple des Jaquet-Droz et Leschot et de leur activité commerciale avec la Chine. Les pendules, cages à oiseaux, montres, tabatières et flacons issus de leurs ateliers sont agrémentés de complications mécaniques, d’oiseaux chanteurs ou d’émaux chatoyants. Ce cas d’étude révèle une réalité complexe où l’excellence n’exclut pas le recours à la sous-traitance et à l’utilisation de modèles techniques et décoratifs.
Buridan’s ass syndrome: Dilemma of the human resources practitioner in workplace bullying
Authors: Mokgolo Manasseh , Barnard Antoni 
Published: June 2019

Orientation: Worldwide, bullying in the workplace is recognised as a sensitive and psychologically destructive issue. It has a detrimental effect on employee well-being, organisations’ productivity and employee relations. As a vital link between different constituencies in the organisation, human resource practitioners struggle in their attempts to address and manage workplace bullying.Research purpose: The aim of this article was to describe the challenges that human resource practitioners face when being tasked with addressing workplace bullying.Motivation for the study: Concern about human resource practitioners’ capacity to manage situations of workplace bullying requires a better understanding of their role in and perspective of the bullying phenomenon.Research approach/design and method: A constructivist, grounded theory research design was used to explore the perspectives of nine human resource practitioners on workplace bullying. Data were gathered through semi-structured interviews to gain insight into and understanding of their experiences of bullying in the workplace.Main findings: Paradoxical role demands, lack of decision-making power and their perceived lack of support from policy and management disable the human resource practitioners’ functionality in addressing workplace bullying.Practical/managerial implications: The study identifies dilemmas that human resource practitioners face, impeding their capacity to address workplace bullying effectively. Findings highlight the practical value of empowering such practitioners in the role they play in dealing with workplace bullying situations.Contribution/value-add: The present study contributes to the limited body of knowledge on human resource practitioners’ perspectives on workplace bullying within the South African context.
Characterization of Bacteriophage against Enterococcus faecium Resistant to Vancomycin Isolated from Chicken Skin
Authors: Azlan Hazzierah Syaffieqah An Nadiah , Hamid Muhajir , Song Adelene Ai-Lian 
Published: June 2019

Aims: To characterize bacteriophages with strong in vitro lytic activity against vancomycin resistant Enterococcus faecium before testing on the chicken skin for their efficacy.
Study Design: An experimental was carried out to characterize two isolated bacteriophages against Enterococcus faecium and test for their efficacy on chicken skin.
Study Place: The study was carried out in Laboratory of Vaccine and Immunotherapeutics, Institue of Bioscience, Universiti Putra Malaysia in Selangor, which is the most populous state in Malaysia.
Methodology: Two host specific lytic phages against vancomycin resistant Enterococcus faecium strain FM8, designated as FM8-P1 and FM8-P2 were physiological characterized. This includes determination of their adsorption rate, multiplicity of infection, and single step growth kinetics. The optimum pH and temperature for both bacteriophages activity were also determined before tested on chicken skin at 4°C and 25°C, which represent chiller and room temperature in poultry production line.
Results: Based on the result of single-step growth kinetics, the latent period of FM8-P1 was 35 min with a burst size of 460 particles per infected cells, while FM8-P2 has a shorter latent period (20 min) but a smaller burst size of 60 particles. The highest adsorption rate for FM8-P1 was 83% and FM8-P2 was 90% at 2 min and 4 min respectively. Both bacteriophages also exihibited a wide range of pH and temperature for their activity.
Conclusion: The specificity, lytic activity and stability of FM8-P1 and FM8-P2 emphasized their potential in effectively eliminating the vancomycin resistant Enterococcus faecium strain FM8. However, further works are required to validate their in situ reliability.
Primary Open Angle Glaucoma: The Pathophysiolgy, Mechanisms, Future Diagnostic and Therapeutic Directions
Authors: Umezurike Benedict C. , Akhimien Moses Obeimen , Udeala Okechukwu , Green Uzoamaka G. , Okpechi-Agbo Ugonma , Ohaeri Maureen U. 
Published: June 2019

Primary open angle glaucoma (POAG) is a multifactorial chronic optic neuropathy, characterized by progressive loss of retinal ganglion cells (RGC), leading to structural damage to the optic nerve head (ONH), retinal nerve fiber layer (RNFL), with visual field defects. It is occasioned by major risk factors of high intraocular pressure (IOP) and age. The pathogenesis of POAG is the imbalance between the production and drainage of the aqueous humour (AH). The resultant fluid back-up increases the IOP with consequent optic nerve damage, causing POAG. Modern diagnosis, using scanning laser polarimetry (SLP), confocal scanning laser ophthalmoscopy (CSLO), optical coherence tomography (OCT) etc, plays a vital role in the assessment of the ONH, RNFL and the macular, in POAG. OCT operates on the principles of interferometery, utilizing light beams and their pattern of back-scattering, to build high resolution cross-sectional images of ocular tissues. It gives an objective evaluation of structural alterations in the ONH or macular area of the retina in vivo. POAG is managed medically using classes of drugs like α-adrenergic agonists, beta-adrenergic receptor antagonist, prostaglandin agonists, carbonic anhydrase inhibitors, ccholinergic agonists etc. Surgical intervention is indicated with laser or incisional surgeries, when medical option fails. Future pharmacotherapeutic directions in POAG management consider transgenic model, genetic model, neuroregeneration (stem cell technique), neurodegeneration (Seeing glaucoma as a neurologic disorder much like in Parkinson's and Alzheimer's diseases and the mechanisms that cause the degeneration of RGCs), autoimmune response and T-cell autoimmune response attack.
Reducing agate dust exposure in Khambhat, India: Protective practices, barriers, and opportunities
Authors: Falk Lindsey , Bozek Paul , Ceolin Lissa , Levitsky Marianne , Malik Om , Patel Jagdish , Sobers Mercedes , Cole Donald C 
Published: June 2019

Abstract

Aims
Agate workers in Khambhat, India and their community members are exposed to high levels of silica dust and related diseases. Use of effective prevention practices remains low, prompting the need for effective interventions which increase the uptake of and investment in prevention practices. We sought: (a) to describe knowledge, self-efficacy, and practices among a population of workers, their family members, and neighbors involved in or located close to agate processing; and (b) to explore which factors are related to use of prevention practices and willingness to invest in new dust control technologies.

Methods
A community survey was conducted to measure demographics, occupation and financial factors, knowledge, prevention practices, barriers, risk perceptions, and efficacy beliefs. Descriptive statistics were used and, among agate workers, hierarchical logistic regression explored predictors of prevention practice use and willingness to invest.

Results
Among 1120 respondents, approximately 44%, 35%, and 8% of workers, family members, and neighbors used prevention practices, respectively. Knowledge and risk perceptions were generally high, where efficacy beliefs were low. Workers who had high levels of education, worked at home, and had high efficacy beliefs were more likely to report using prevention practices and being willing to invest. Barriers to prevention practice use included financial barriers, and beliefs that prevention is ineffective and health is not at risk.

Conclusions
Interventions and future research should be designed to engage the community to improve preventive behavior, and implement affordable and effective dust control interventions in the agate industry.
DMF as Methine Source: Copper‐Catalyzed Direct Annulation of Hydrazides to 1,3,4‐Oxadiazoles
Authors: Wang Shoucai , Wang Kai , Kong Xiangfei , Zhang Shuhua , Jiang Guangbin , Ji Fanghua 
Published: June 2019

AbstractAn unprecedented Cu‐catalyzed direct annulation of hydrazides with N,N‐dimethylformamide (DMF) was developed, providing an efficient synthesis of valuable 1,3,4‐oxadiazoles. This process features the short reaction time and can be safely conducted on gram scale. The reaction also facilitated the convenient synthesis of 1,3,4‐oxadiazole‐2(3H)‐ones. Moreover, the mechanistic studies suggest that the source of CH is from the N‐methyl group of DMF.magnified image
Metallosupramolecular Architectures of Ambivergent Bis(Amino Acid) Biphenyldiimides
Authors: Boer Stephanie A. , Turner David R. 
Published: June 2019

AbstractThe metallosupramolecular chemistry of two enantiopure dicarboxylate ligands has been explored for their potential to form discrete or polymeric interlocked motifs. Consequently, both discrete and polymeric supramolecular complexes have been synthesised, yielding M2L2 metallomacrocycles (1 and 2), a heteroleptic M2L3 metallomacrobicycle (3), a non‐interpenetrated coordination polymer (4), and highly unusual chiral M8L8 squares (5 and 6). There appears to be a preference for the ligands to form M2L2‐type metallomacrocyclic structural units (which feature in 1–4), although these do not engage in any mechanical interlocking, which is perhaps a combined function of the ligand flexibility and relatively small pi‐surface contrasted to previous analogues. Using copper paddlewheel SBUs, chiral double‐walled squares (5 and 6) are formed with large internal cavities yet poor stabilities, unexpectedly featuring the paddlewheel motifs at the vertices of the polygonal complex.
P2X receptors mediated abnormal interaction between satellite glial cells and neurons in visceral pathological changes
Authors: Wang Zilin , Li Lin , Yang Runan , Xu Xiumei , Liang Shangdong 
Published: June 2019

AbstractThe adenosine triphosphate (ATP)‐gated P2X receptor cation channel family consists of permeable ligand‐gated ion channels that expand on the binding of extracellular adenosine 5’‐ATP. ATP‐gated P2X receptors are trimer ion channels that assemble homo or isomer from seven cloned subunits. P2X receptors are discovered mostly in mammalian and are being found in an increasing number of non‐vertebrates, such as zebrafish, bullfrog, and ameba. P2X receptors are involved in many physiological processes, including regulation of heart rhythm and contractility, and regulation of pain, especially chronic pain and glia integration. This review summarizes the current studies on the regulation of P2X receptors in abnormal neuronal‐glial interaction and the pathological changes in viscera, especially in myocardial ischemia.
Nano‐Micro‐Structured Nickel‐Cobalt Hydroxide/Ni2P2O7 Assembly on Nickel Foam: An Outstanding Electrocatalyst for Alkaline Oxygen Evolution Reaction
Authors: Chodankar Nilesh R. , Bagal Indrajit V. , Ryu Sang‐Wan , Han Young‐Kyu , Kim Do‐Heyoung 
Published: June 2019

AbstractThe design and development of materials for the efficient electrochemical evolution of oxygen from hydroxyl ions in alkaline media is of prime importance for reducing energy losses in water‐alkaline electrolytes. In this Communication, we report non‐noble nano‐micro‐structured Ni2P2O7 microsheets decorated with nickel‐cobalt hydroxide (Ni−Co‐hydroxide) nanoflakes for the efficient oxygen evolution reaction (OER). Remarkably, the nano‐micro‐assembled Ni−Co‐hydroxide/Ni2P2O7 structured electrode exhibits superior catalytic activity towards the OER with a relatively low overpotential of 197 mV at a current density of 10 mA/cm2 in 1.0 M KOH, coupled with excellent long‐term stability (12 h). The outstanding OER activity resulted from the nano‐micro structure of the prepared electrode with excellent redox activity in an alkaline electrolyte.
Secukinumab Treatment Does Not Alter the Pharmacokinetics of the Cytochrome P450 3A4 Substrate Midazolam in Patients With Moderate to Severe Psoriasis
Authors: Bruin Gerard , Hasselberg Anke , Koroleva Irina , Milojevic Julie , Calonder Claudio , Soon Rachel , Woessner Ralph , Pariser David M. , Boutouyrie‐Dumont Bruno 
Published: June 2019

This open‐label disease‐drug–drug interaction study assessed whether blockade of the interleukin (IL)‐17A pathway by secukinumab and subsequent downregulation of inflammatory cytokines like IL‐6 or high‐sensitivity C‐reactive protein affects the pharmacokinetics (PKs) of a sensitive probe substrate of the cytochrome P450 3A4 isoform (CYP3A4). The PKs of midazolam, metabolized by CYP3A4, was evaluated before and after 7 and 35 days of treatment initiation of subcutaneous secukinumab at a dose of 300 mg weekly in 24 patients with moderate‐to‐severe psoriasis. Although demonstrating the expected decrease in downstream inflammatory cytokines, secukinumab had no clinically relevant effects on the PKs of midazolam, provided substantial clinical benefit, and was generally well tolerated. In summary, blockade of IL‐17A signaling in patients with moderate‐to‐severe psoriasis does not significantly affect CYP3A4 enzyme activities and, therefore, the use of secukinumab is unlikely to influence the PKs of CYP3A4 substrates.
SEM/FIB Imaging for Studying Neural Interfaces
Authors: Henn Itai , Atkins Ayelet , Markus Amos , Shpun Gal , Barad Hannah‐Noa , Farah Nairouz , Mandel Yossi 
Published: June 2019

AbstractTissue and neural engineering for various regenerative therapies are rapidly growing fields. Of major interest is studying the complex interface between cells and various 3D structures by scanning electron microscopy with focused ion beam. Notwithstanding its unrivaled resolution, the optimal fixation, dehydration, and staining protocols of the samples while preserving the complex cell interface in its natural form, are highly challenging. The aim of this work was to compare and optimize staining and sample drying procedures in order to preserve the cells in their “life‐like state” for studying the cell interface with either 3D well‐like structures or gold‐coated mushroom‐shaped electrodes. The process involved chemical fixation using a combination of glutaraldehyde and formaldehyde, followed by gentle drying techniques in which we compared four methods: (critical point drying, hexamethyldisiloxane, repeats of osmium tetroxide–thiocarbohydrazide [OTOTO], and resin) in order to determine the method that best preserves the cell and cell interface morphology. Finally, to visualize the intracellular organelles and membrane, we compared the efficacy of four staining techniques: osmium tetroxide, osmium tetroxide and salts, osmium and uranyl acetate, and OTOTO. Experiments were performed on embryonic stem cell‐derived photoreceptor precursors, neural cells, and a human retinal pigment epithelial cell line, which revealed that the optimal processing combination was resin drying and OTOTO staining, as manifested by preservation of cell morphology, the lowest percentage of cellular protrusion breakage as well as a high‐quality image. The obtained results pave the way for better understanding the cell interface with various structures for enhancing various biomedical applications.