bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cutaneous mucormycosis as a presenting feature of type 1 diabetes in a boy – case report and review of the literature
Authors: Jevalikar Ganesh , Sudhanshu Siddhnath , Mahendru Sanjay , Sarma Smita , Farooqui Khalid J. , Mithal Ambrish 
Published: April 2018

Abstract

Background:
Mucormycosis is a potentially fatal complication of diabetes. The rhino-orbito-cerebral form is the most common presentation, however, rarely other types can also be seen.

Case presentation:
We describe the case of a 4½ -year-old boy not previously known to be a diabetic who presented to the plastic surgery department for gangrene of the left middle finger with surrounding erythema and induration. After the diagnosis of diabetes and initial treatment, pus from the wound showed broad aseptate hyphae suggestive of mucormycosis which was further confirmed on culture. Aggressive surgical debridement including amputation, antifungal treatment and glycemic control achieved a complete cure.

Conclusions:
Cutaneous mucormycosis is a rare complication of type 1 diabetes mellitus and can even be seen at the onset of diabetes. High index of suspicion, timely antifungal treatment and aggressive surgical debridement usually lead to recovery in the localized form of the disease.
Contemporary Management of Mangled Extremity: A Review
Authors: Kaftandziev Igor , Spasov Marko , Pendovska Bisera 
Published: April 2018

Abstract
The treatment of choice of mangled extremities continues to be a subject of debate among surgeons.
Nowadays, much of the extremities that used to be amputated are saved, which is due to the progress in the fields of resuscitation, microvascular techniques, and advancements in fracture fixation. However, even if technical possibility of extremity salvage exists, the surgeon must always keep in mind that the final goal of the treatment is good functional outcome and to choose the modality of treatment in accordance to the principle. It is well-known that the final outcome following the treatment of the mangled extremities is influenced by plenty of factors. Until now, there are many scoring systems that are intended to guide the surgeon during the decision-making process in the acute phase of the treatment of mangled extremities. Nonetheless, many agree that the predictive value of these systems is still questionable. The process of limb salvage is lengthy, challenging and expensive, and in certain instances reoperations are necessary. Yet, morbidity and mortality are still significant.
The aim of our review was to present the current knowledge regarding the mechanism of injury and initial treatment of the mangled extremity and the scoring systems available. Furthermore, we are going to discuss the controversies concerning definitive treatment and complications following these injuries.
Characteristics of Acute Kidney Injury in Neonatal Age At - Intensive Care Unit
Authors: Naunova-Timovska Silvana 
Published: April 2018

Abstract
Introduction. Acute kidney injury is a serious condition which damages the kidney as a central mediator of the homeostasis of bodily fluids and electrolytes. It is not a rare problem in the intensive care units, particularly in the neonatal population. Perinatal asphyxia is a common predisposing factor associated with neonatal kidney injury. The aim of this study was to determine the characteristics of acute kidney injury in newborns from neonatal intensive care unit and to explore the association with perinatal asphyxia.
Methods. The study was conducted at the Children’s University Hospital in Skopje, R. Macedonia. It was a clinical, prospective study. In the period of two years (January 2013 to December 2014) 29 patients hospitalized at the Neonatal Intensive Care Unit (NICU) with documented neonatal kidney injury were analyzed. Medical data records of admitted neonates with kidney injury were analyzed. The material was statistically analyzed using methods of descriptive statistics.
Results. We evaluated 29 neonates with documented acute kidney injury who at the period of 2 years were treated in NICU. The prevalence of kidney injury was 6.4%. Most of involved neonates were born at term (66%). Prerenal injury was evaluated in 80% of cases. Perinatal asphyxia was the most common predisposing factors for kidney injury in our study, revealed in 56% of cases with predominance of term-infants and male gender. Sepsis was present in 44% of cases, prematurity in 34%, and congenital malformation in 27% of cases. Mortality rate was 27.5% and it was higher in patients with assisted ventilation and sepsis.
Conclusion. Perinatal asphyxia is a dominant predisposing factor associated with neonatal kidney injury. Often, the occurrence of kidney damage in the neonatal population is multifactorial (more than 40%) and caused by several associated comorbidities
Development of resistant corn starch for use as an oral colon-specific nanoparticulate drug carrier
Authors: Ab’lah Norul Nazilah , Konduru Venkata Nagarjun , Wong Tin Wui 
Published: April 2018

Abstract
Starch is constituted of amylose and amylopectin. Debranching of amylopectin converts it into amylose thereby producing resistant starch which is known to be less digestible by the amylase. This study designed resistant starch using acid hydrolysis and heat-moisture treatment methods with native corn starch as the starting material. Both native and processed starches were subjected to Fourier transform infrared spectroscopy, X-ray diffractometry, differential scanning calorimetry and molecular weight analysis. They were nanospray-dried into nanoparticles with 5-fluorouracil as the drug of interest for colon cancer treatment. These nanoparticles were subjected to size, zeta potential, morphology, drug content and in vitro drug release analysis. Heat-moisture treatment of native corn starch enabled the formation of resistant starch through amylopectin debranching and molecular weight reduction thereby enhancing hydrogen bonding between the starch molecules at the amorphous phase and gelatinization capacity. The nanoparticles prepared from resistant starch demonstrated similar drug release as those of native starch in spite of the resistant starch had a lower molecular weight. The resistant starch is envisaged to be resistant to the digestive action of amylase in intestinal tract without the formed nanoparticles exhibiting excessively fast drug release in comparison to native starch. With reduced branching, it represents an ideal precursor for targeting ligand conjugation in design of oral colon-specific nanoparticulate drug carrier.
Multivariable polynomial fitting of controlled single-phase nonlinear load of input current total harmonic distortion
Authors: Sikora Roman , Markiewicz Przemysław , Pabjańczyk Wiesława 
Published: April 2018

Abstract
The power systems usually include a number of nonlinear receivers. Nonlinear receivers are the source of disturbances generated to the power system in the form of higher harmonics. The level of these disturbances describes the total harmonic distortion coefficient THD. Its value depends on many factors. One of them are the deformation and change in RMS value of supply voltage. A modern LED luminaire is a nonlinear receiver as well. The paper presents the results of the analysis of the influence of change in RMS value of supply voltage and the level of dimming of the tested luminaire on the value of the current THD. The analysis was made using a mathematical model based on multivariable polynomial fitting.
Energy industry
Authors: Staszak Katarzyna , Wieszczycka Karolina 
Published: April 2018

AbstractThe potential sources of metals from energy industries are discussed. The discussion is organized based on two main metal-contains wastes from power plants: ashes, slags from combustion process and spent catalysts from selective catalytic NOxreduction process with ammonia, known as SCR. The compositions, methods of metals recovery, based mainly on leaching process, and their further application are presented. Solid coal combustion wastes are sources of various compounds such as silica, alumina, iron oxide, and calcium. In the case of the spent SCR catalysts mainly two metals are considered: vanadium and tungsten – basic components of industrial ones.
Production and separation of no-carrier-added 181−184Re radioisotopes from proton irradiated tungsten target
Authors: Choudhury Dibyasree , Naskar Nabanita , Lahiri Susanta 
Published: April 2018

Abstract
Cross sections for the production of 181−184Re isotopes from proton irradiated thin natWO3 target at 20.9, 17.9, 14.9, 11.9 and 8.8 MeV projectile energies have been measured. An acceptable agreement between experimentally obtained data and available literature reports was found. The produced no-carrier-added (NCA) Re radionuclides have been separated from bulk tungsten target by liquid-liquid extraction (LLX) using trioctyl amine (TOA) and di-(2-ethylhexyl)phosphoric acid (HDEHP) dissolved in cyclohexane. A clear separation has been observed at 0.1 M and 1 M TOA with 0.1 M HNO3 concentration. However, by using HDEHP NCA Re radionuclides could not be separated from bulk W target without its contamination.
Thermal neutron activation analysis of some toxic and trace chemical element contents in Mentha pulegium L.
Authors: Begaa Samir , Messaoudi Mohammed 
Published: April 2018

Abstract
Our laboratory of neutron activation analysis is highly involved in nutrition applications in the framework of research activities using the Algerian research reactor. The medicinal and aromatic plants of Mentha pulegium L. have been largely used in traditional medicine for several centuries to contribute significantly to human health related to digestive ailments, it is also used to reduce nervousness and anxiety. The present study focuses on the analysis of leaves of M. pulegium L., for evaluation of essential and toxic elements using a sensitive nuclear analytical technique based on instrumental neutron activation analysis (INAA). Twenty-one elements were assessed (As, Ba, Br, Ca, Ce, Cr, Cs, Co, Eu, Fe, Hf, K, La, Na, Rb, Sb, Sc, Sm, Sr, Yb and Zn) and the accuracy of the method was evaluated by analyzing the Certified Reference Materials (CRMs) GBW 07605 (tea leaves) and NIST-SRM 1573a (tomato leaves). The daily intake of essential and toxic elements was determined and compared with the recommended values and was found to be well below the tolerance limits.
Mechanism of bacterial adhesion on ultrafiltration membrane modified by natural antimicrobial polymers (chitosan) and combination with activated carbon (PAC)
Authors: Gafri Hasan Fouzi S. , Mohamed Zuki Fathiah , Aroua Mohamed Kheireddine , Hashim Nur Awanis 
Published: April 2018

AbstractBacterial adhesion to surfaces is related to several factors, such as surface charge, surface energy, and substrate characteristics (leading to the formation of biofilms). Organisms are dominant in most environmental, industrial, and medical problems and processes that are of interest to microbiologists. Biofilm cells are at least 500 times more resistant to antibacterial agents compared to planktonic cells. The usage of ultrafiltration membranes is fast becoming popular for water treatment. Membrane lifetime and permeate flux are primarily affected by the phenomena of microbial accumulation and fouling at the membrane’s surface. This review intends to understand the mechanism of membrane fouling by bacterial attachment on polymeric ultrafiltration membrane modified by natural antimicrobial polymers (chitosan) combined with powder activated carbon. Also, to guide future research on membrane water treatment processes, adhesion prediction using the extended Derjaguin-Landau-Verwey-Overbeek theory is discussed.
Gerechtigkeit im SGB II: Auswirkungen von prozeduralen Gerechtigkeitswahrnehmungen von Hartz-IV-Empfängern auf ihre Bereitschaft, mit dem Jobcenter zu kooperieren
Authors: May Meike Janina 
Published: April 2018

AbstractZiel aktivierender Arbeitsmarktpolitik ist die (Wieder-)Eingliederung von Arbeitslosen in den Arbeitsmarkt. Voraussetzung für die erfolgreiche Vermittlung ist u.a. die Bereitschaft von Arbeitslosen mit den SGB II-Trägern und deren Mitarbeiter/-innen zusammenzuarbeiten. Der vorliegende Beitrag untersucht, inwieweit prozedurale Gerechtigkeitswahrnehmungen von Arbeitslosengeld II-Empfängern diese Kooperationsbereitschaft beeinflussen. Die Analysen basieren auf einer repräsentativen Stichprobe von ALG II-Haushalten in Deutschland (sechste Welle des PASS, Analysestichprobe: 1.990 ALG II-Empfänger). Die Ergebnisse zeigen, dass je ungerechter Arbeitslose die Verfahren der Jobcenter bewerten (Verfahrensgerechtigkeit) und je ungerechter sie sich von ihrem Vermittler oder ihrer Vermittlerin behandelt fühlen (Interaktionsgerechtigkeit), desto weniger sind sie bereit mit dem Jobcenter zu kooperieren. Die Mediatorvariable für diesen Zusammenhang ist das Vertrauen der Arbeitslosen in das Jobcenter und seine Mitarbeiter/-innen.
Effects of Pile Installation Simulation on Behavior of Pile Groups in Centrifuge Model Tests
Authors: Li Yang , Zhang Ga , Liu Chunying 
Published: April 2018

Abstract
Centrifuge model testing plays an important role in investigations of the bearing behavior of pile groups and its underlying mechanisms, for which pile installation simulation is a key issue. Centrifuge model tests were conducted to analyze the effect of different pile installation simulation methods, namely traditional installation at 1 g and in-flight installation at 50 g. Compared to the traditional method, the in-flight pile installation induces two effects: the deformation effect, in which the neighboring soil is made denser, and the shielding effect, in which the existing piles influence the deformation and pore pressure of the neighboring soil. Thus, the limit-bearing capacity and corresponding settlement of the pile group using the in-flight pile installation method are significantly greater, and the deformation and excess pore pressure of the soil near piles are smaller. The traditional pile installation method obtains unrealistic responses of pile groups because it cannot adequately simulate these effects.
Quadruple valve replacement in a patient with severe rheumatic heart disease
Authors: Adembesa Isaac , Myburgh Adriaan , Swanevelder Justiaan 
Published: April 2018

Summary
We present a patient with rheumatic heart disease involving all the heart valves. An intraoperative transoesophageal echocardiography confirmed severe mitral stenosis, severe aortic regurgitation, severe tricuspid regurgitation and stenosis, and severe pulmonary stenosis. The patient underwent successful quadruple valve replacement during a single operation at the Groote Schuur Hospital, Cape Town, South Africa.
Interrogating the Functions of PRDM9 Domains in Meiosis
Authors: Thibault-Sennett Sarah , Yu Qi , Smagulova Fatima , Cloutier Jeff , Brick Kevin , Camerini-Otero R Daniel , Petukhova Galina V 
Published: April 2018

Abstract
Homologous recombination is required for proper segregation of homologous chromosomes during meiosis. It occurs predominantly at recombination hotspots that are defined by the DNA binding specificity of the PRDM9 protein. PRDM9 contains three conserved domains typically involved in regulation of transcription; yet, the role of PRDM9 in gene expression control is not clear. Here, we analyze the germline transcriptome of Prdm9−/− male mice in comparison to Prdm9+/+ males and find no apparent differences in the mRNA and miRNA profiles. We further explore the role of PRDM9 in meiosis by analyzing the effect of the KRAB, SSXRD, and post-SET zinc finger deletions in a cell culture expression system and the KRAB domain deletion in mice. We found that although the post-SET zinc finger and the KRAB domains are not essential for the methyltransferase activity of PRDM9 in cell culture, the KRAB domain mutant mice show only residual PRDM9 methyltransferase activity and undergo meiotic arrest. In aggregate, our data indicate that domains typically involved in regulation of gene expression do not serve that role in PRDM9, but are likely involved in setting the proper chromatin environment for initiation and completion of homologous recombination.
Improved Use of Small Reference Panels for Conditional and Joint Analysis with GWAS Summary Statistics
Authors: Deng Yangqing , Pan Wei 
Published: April 2018

Abstract
Due to issues of practicality and confidentiality of genomic data sharing on a large scale, typically only meta- or mega-analyzed genome-wide association study (GWAS) summary data, not individual-level data, are publicly available. Reanalyses of such GWAS summary data for a wide range of applications have become more and more common and useful, which often require the use of an external reference panel with individual-level genotypic data to infer linkage disequilibrium (LD) among genetic variants. However, with a small sample size in only hundreds, as for the most popular 1000 Genomes Project European sample, estimation errors for LD are not negligible, leading to often dramatically increased numbers of false positives in subsequent analyses of GWAS summary data. To alleviate the problem in the context of association testing for a group of SNPs, we propose an alternative estimator of the covariance matrix with an idea similar to multiple imputation. We use numerical examples based on both simulated and real data to demonstrate the severe problem with the use of the 1000 Genomes Project reference panels, and the improved performance of our new approach.
Unmet Rehabilitation Needs After Hospitalization for Traumatic Brain Injury
Authors: Fuentes Molly M. , Wang Jin , Haarbauer-Krupa Juliet , Yeates Keith Owen , Durbin Dennis , Zonfrillo Mark R. , Jaffe Kenneth M. , Temkin Nancy , Tulsky David , Bertisch Hilary , Rivara Frederick P. 
Published: April 2018

OBJECTIVES:
In this study, we describe unmet service needs of children hospitalized for traumatic brain injury (TBI) during the first 2 years after injury and examine associations between child, family, and injury-related characteristics and unmet needs in 6 domains (physical therapy, occupational therapy, speech therapy, mental health services, educational services, and physiatry).

METHODS:
Prospective cohort study of children age 8 to 18 years old admitted to 6 hospitals with complicated mild or moderate to severe TBI. Service need was based on dysfunction identified via parent-report compared with retrospective baseline at 6, 12, and 24 months. Needs were considered unmet if the child had no therapy services in the previous 4 weeks, no physiatry services since the previous assessment, or no educational services since injury. Analyses were used to compare met and unmet needs for each domain and time point. Generalized multinomial logit models with robust SEs were used to assess factors associated with change in need from pre-injury baseline to each study time point.

RESULTS:
Unmet need varied by injury severity, time since injury, and service domain. Unmet need was highest for physiatry, educational services, and speech therapy. Among children with service needs, increased time after TBI and complicated mild TBI were associated with a higher likelihood of unmet rather than met service needs.

CONCLUSIONS:
Children hospitalized for TBI have persistent dysfunction with unmet needs across multiple domains. After initial hospitalization, children with TBI should be monitored for functional impairments to improve identification and fulfillment of service needs.
Фітомеліоративна ефективність вуличних фітоценозів як один із параметрів екологічного виміру збалансованого розвитку міста
Authors: Lukyanchuk N. , Martynyuk H. 
Published: April 2018

Запропоновано введення параметра «коефіцієнт фітомеліоративної ефективності насаджень» у розрахунок індексу екологічного виміру збалансованого розвитку міської екосистеми. Проаналізовано особливості архітектурно-планувальної ситуації Львова. Визначено середньодобову інтенсивність руху автомобілів та вивчено фітомеліоративну роль насаджень вздовж вулиць Городоцької, Івана Франка та Євгена Коновальця. Визначено коефіцієнт фітомеліоративної ефективності насаджень вздовж транспортних магістралей, що дає змогу інформаційно доповнити екологічний складник виміру збалансованого розвитку міської екосистеми. Встановлено ступінь виконання фітомеліоративних функцій фітоценозів. Подано пропозиції щодо оптимізації рослинного покриву вулиць.
Методологічні аспекти створення геоінформаційної системи лісових автодоріг
Authors: Korzhov V. , Chaskovskyу O. 
Published: April 2018

Здійснено аналіз тенденцій розвитку геоінформаційних систем (ГІС) в лісовій галузі та міжнародних вимог стосовно запровадження природозберігаючих технологій на базі оптимальної транспортної мережі як передумови для реального запровадження принципів сталого ведення лісового господарства. Обґрунтовано необхідність наявності об’єктивних даних про транспортну мережу лісових підприємств. Подано методичні підходи до створення ГІС лісових автодоріг, які передбачають подання інформації про лісові автодороги як лінійні об'єкти з відомими координатами вздовж дороги та наявністю певної кількості каліброваних точок, тобто коректно розташованої лінії, що відображає дорогу, і відомостей про неї у вигляді таблиць та фото (креслень), які відображають її технічні та експлуатаційні характеристики. Також висвітлено особливості структури і порядку роботи та операційні можливості дослідної ГІС лісових автодоріг, розробленої для ДП «Осмолодське лісове господарство».
A Educação Infantil Religiosa e Políticas Públicas no Brasil
Authors: Valadares Nogueira Celeide Agapito 
Published: April 2018

RESUMO O intuito deste texto é discorrer sobre a educação infantil e o lugar do ensino religioso entre o Educar o Cuidar na diversidade de pertença religiosa de um país laico. Vislumbrando a compreensão deste processo educativo,como as políticas públicas contemplam este propósito no Brasil? Buscar-se-á então uma hermenêutica compreensiva em aporte teórico-metodológico e o diálogo profícuo entre autores que versam sobre tal temática. Palavras-chaves: Ensino religioso – diversidade – educação infantil.
Religião, morte e políticas públicas de saúde: cientistas das religiões na elaboração dos processos de luto.
Authors: Franco Clarissa De , Torres Valéria Rocha 
Published: April 2018

O presente artigo tem por objetivo refletir a respeito da Ciência das Religiões aplicada e sua interlocução com políticas públicas de saúde voltadas ao enfrentamento do luto por morte. Abordamos questão de tamanha complexidade a partir de um diálogo entre Psicologia e História duas áreas do conhecimento interlocutoras da Ciência das Religiões para demonstramos a historicidade do embate político sobre a morte entre o conhecimento médico-científico e o conhecimento de matriz religiosa, embate que atravessa todo o século XIX e XX, vindo a produzir, a partir do processo de secularização e das expectativas de modernidade e racionalização da sociedade, uma política do esquecimento, negação e empobrecimento dos processos de elaboração do luto por morte a partir das matrizes religiosas e simbólicas. Assim, também trazemos o ponto de vista da psicologia sobre os impactos que a retomada deste conhecimento pode produzir na elaboração de políticas públicas de enfrentamento da morte por luto no Brasil.