bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proximal Adductor Avulsion Injuries: Outcomes of Surgical Reattachment in Athletes
Authors: Bharam Srino , Feghhi Daniel P. , Porter David A. , Bhagat Priyal V. 
Published: July 2018

Background: Sports-related groin injuries are common among athletes. However, traumatic proximal adductor avulsion injuries are relatively rare groin injuries in the athletic population, with limited case reports describing suture anchor repair. Purpose: To report on the outcomes of surgical reattachment of proximal adductor avulsion injuries in athletes utilizing a suture anchor repair technique. Study Design: Case series; Level of evidence, 4. Methods: Prospective data were collected on patients undergoing surgical reattachment of proximal adductor avulsion injuries from December 2012 to May 2015 by a single surgeon. Six athletes presented after a traumatic sports-related injury with disabling groin pain, adductor weakness, and magnetic resonance imaging confirmation of fibrocartilage avulsion of the proximal adductor with retraction. Patient-reported outcomes (Hip Outcome Score–Activities of Daily Living [HOS-ADL] and Hip Outcome Score–Sport Specific [SS] subscales, modified Harris Hip Score [mHHS], and visual analog scale [VAS] for pain) were collected preoperatively and at a minimum 2-year follow-up. Results: The latest follow-up of each patient averaged 33.4 months postoperatively (range, 25-42.5 months). All patients returned to sporting activities, with 1 minor wound complication that resolved. Paired-samples t tests indicated that the mean latest postoperative scores for all patients were significantly better than their mean preoperative scores (HOS-ADL: 99.0 vs 43.2, HOS-SS: 98.9 vs 8.3, and mHHS: 97.1 vs 44.6, respectively; P < .001 for all). Similarly, there was a significant improvement in mean postoperative VAS scores for all patients (from 89.2 to 2.2; P < .001). Conclusion: Patient-reported outcomes offer an objective measure of hip function and pain control. Surgical reattachment utilizing a multiple suture anchor technique is a successful procedure that allows for a safe return to athletic performance and a predictable return to sport.
Using semantic clustering to support situation awareness on Twitter: the case of world views
Authors: Kingston Charlie , Nurse Jason R. C. , Agrafiotis Ioannis , Milich Andrew Burke 
Published: July 2018

AbstractIn recent years, situation awareness has been recognised as a critical part of effective decision making, in particular for crisis management. One way to extract value and allow for better situation awareness is to develop a system capable of analysing a dataset of multiple posts, and clustering consistent posts into different views or stories (or, ‘world views’). However, this can be challenging as it requires anunderstandingof the data, including determining what is consistent data, and what data corroborates other data. Attempting to address these problems, this article proposesSubject-Verb-Object Semantic Suffix Tree Clustering(SVOSSTC) and a system to support it, with a special focus on Twitter content. The novelty and value of SVOSSTC is its emphasis on utilising the Subject–Verb–Object typology in order to construct semantically consistent world views, in which individuals—particularly those involved in crisis response—might achieve an enhanced picture of a situation from social media data. To evaluate our system and its ability to provide enhanced situation awareness, we tested it against existing approaches, including human data analysis, using a variety of real-world scenarios. The results indicated a noteworthy degree of evidence (e.g., in cluster granularity and meaningfulness) to affirm the suitability and rigour of our approach. Moreover, these results highlight this article’s proposals as innovative and practical system contributions to the research field.
Neisseria Gonorrhoae and their antimicrobial susceptibility patterns among symptomatic patients from Gondar town, north West Ethiopia
Authors: Yeshanew Addisu Gize , Geremew Rozina Ambachew 
Published: July 2018

Abstract
Background
Neisseria gonorrhoeae, the causative agent of gonorrhoea, is a Gram negative, coffee-bean shaped facultative intracellular diplococcus bacterium, the classical sexually transmitted bacteria. Nowadays, N. gonorrhoeae has developed high-level resistance to all traditional antimicrobials used for the treatment of gonorrhoea and makes the treatment complicated. So, the aim of this study was to determine magnitude and antimicrobial resistance patterns of N. gonorrhoeae.

Methods
A cross sectional study was conducted between April and August 2016 among STI clinic clients in Gondar town hospitals and health centers. Urethral swab and cervical swab specimens were inoculated to Thayer Martin media (OXOID, UK) plates. Observation of Gram-negative intracellular diplococcic was a presumptive diagnosis of gonococcal infection. Finally, antimicrobial susceptibility was assessed by using a modified Kirby-Bauer disk diffusion test, with results indicating susceptible, intermediate or resistant. Data were entered and analyzed using SPSS version 20.

Results
The overall prevalence of laboratory confirmed N. gonorrhoeae was 25(20.8%). The isolated N. gonorrhoeae was resistant 100% to tetracycline, penicillin and 80% percent was multidrug resistant.

Conclusion
Prevalence and drug resistance of N. gonorrhoeae were high in the study area. A large study is needed in order to know the magnitude in the community as well as to increase awareness of both regional health bureaus and the Ministry of Health about the treatment guide-lines.
Aesthetic and functional bra attributes as emotional triggers
Authors: Greggianin Mônica , Tonetto Leandro Miletto , Brust-Renck Priscila 
Published: July 2018

AbstractThis paper aims to evaluate how bra design can trigger positive emotional experiences among users through aesthetic and functional attributes. To achieve this aim, the relationships between women and their favorite bras were investigated, since the users’ preferred products tend to evoke positive experiences. Emotional experiences while using the chosen bras were accessed through five measures: Arousal (intensity of an emotional response); Valence (degree of pleasantness); Dominance (degree of control experienced by the person facing a stimulus); how attractive the chosen bra is; and agreement levels with sentences stating that each design attribute from a list (aesthetic and functional) was determinant for the choice of a certain bra as favorite. The research instrument was a printed questionnaire, which was answered by 182 women. The results indicate that pleasantness (Valence) was related to relaxation (low Arousal), but the feeling of being in control (Dominance), when wearing the chosen bra, was not connected to pleasantness. Attractiveness of the bra, relaxation and pleasantness were related to both aesthetic and functional attributes. The feeling of being in control when using the chosen bra was mostly related to functional attributes. Results are discussed to foster bra design with potential to evoke positive experiences among users.
Getting a balance between generalisation and specialisation in mental health services: a defence of general services
Authors: Laugharne Richard , Thompson Matthew , Srivastava Alind , Marlow Simon , Shankar Rohit 
Published: July 2018

Mental health services in the UK National Health Service have evolved to include primary-care generalist, secondary-care generalist and secondary-care specialist services. We argue that there continues to be an important role for the secondary-care generalists as they minimise interfaces, can live with diagnostic uncertainty and support continuity of care. The lack of commissioning and clinical boundaries in secondary-care generalist services can undermine their feasibility, leading to difficulties recruiting and retaining staff. There is a risk of a polo-mint service, where the specialist services on the edge are well resourced, but the secondary-care generalist services taking the greatest burden struggle to recruit and retain clinicians. We need to establish equity in resources and expectations between generalist and specialist mental health services.Declaration of interestNone.
Predictive physiological anticipatory activity preceding seemingly unpredictable stimuli: An update of Mossbridge et al’s meta-analysis
Authors: Duggan Michael , Tressoldi Patrizio 
Published: July 2018

Background: This is an update of the Mossbridge et al’s meta-analysis related to the physiological anticipation preceding seemingly unpredictable stimuli which overall effect size was 0.21; 95% Confidence Intervals: 0.13 - 0.29 Methods: Nineteen new peer and non-peer reviewed studies completed from January 2008 to June 2018 were retrieved describing a total of 27 experiments and 36 associated effect sizes. Results: The overall weighted effect size, estimated with a frequentist multilevel random model, was: 0.28; 95% Confidence Intervals: 0.18-0.38; the overall weighted effect size, estimated with a multilevel Bayesian model, was: 0.28; 95% Credible Intervals: 0.18-0.38. The weighted mean estimate of the effect size of peer reviewed studies was higher than that of non-peer reviewed studies, but with overlapped confidence intervals: Peer reviewed: 0.36; 95% Confidence Intervals: 0.26-0.47; Non-Peer reviewed: 0.22; 95% Confidence Intervals: 0.05-0.39. Similarly, the weighted mean estimate of the effect size of Preregistered studies was higher than that of Non-Preregistered studies: Preregistered: 0.31; 95% Confidence Intervals: 0.18-0.45; No-Preregistered: 0.24; 95% Confidence Intervals: 0.08-0.41. The statistical estimation of the publication bias by using the Copas selection model suggest that the main findings are not contaminated by publication bias. Conclusions: In summary, with this update, the main findings reported in Mossbridge et al’s meta-analysis, are confirmed.
Computational assessment of stomach tumor volume from multi-slice computerized tomography images in presence of type 2 cancer
Authors: Chacón Gerardo , Rodríguez Johel E. , Bermúdez Valmore , Vera Miguel , Hernández Juan Diego , Vargas Sandra , Pardo Aldo , Lameda Carlos , Madriz Delia , Bravo Antonio J. 
Published: July 2018

Background: The multi–slice computerized tomography (MSCT) is a medical imaging modality that has been used to determine the size and location of the stomach cancer. Additionally, MSCT is considered the best modality for the staging of gastric cancer. One way to assess the type 2 cancer of stomach is by detecting the pathological structure with an image segmentation approach. The tumor segmentation of MSCT gastric cancer images enables the diagnosis of the disease condition, for a given patient, without using an invasive method as surgical intervention. Methods: This approach consists of three stages. The initial stage, an image enhancement, consists of a method for correcting non homogeneities present in the background of MSCT images. Then, a segmentation stage using a clustering method allows to obtain the adenocarcinoma morphology. In the third stage, the pathology region is reconstructed and then visualized with a three–dimensional (3–D) computer graphics procedure based on marching cubes algorithm. In order to validate the segmentations, the Dice score is used as a metric function useful for comparing the segmentations obtained using the proposed method with respect to ground truth volumes traced by a clinician. Results: A total of 8 datasets available for patients diagnosed, from the cancer data collection of the project, Cancer Genome Atlas Stomach Adenocarcinoma (TCGASTAD) is considered in this research. The volume of the type 2 stomach tumor is estimated from the 3–D shape computationally segmented from the each dataset. These 3–D shapes are computationally reconstructed and then used to assess the morphopathology macroscopic features of this cancer. Conclusions: The segmentations obtained are useful for assessing qualitatively and quantitatively the stomach type 2 cancer. In addition, this type of segmentation allows the development of computational models that allow the planning of virtual surgical processes related to type 2 cancer.
Revisión integradora sobre intervenciones escolares para la prevención primaria de la obesidad infantil
Authors: De la fuente Marañón Celia , Cervera Gasch Agueda 
Published: July 2018

Objetivos: El presente estudio tiene por objetivo reunir la evidencia disponible sobre las intervenciones escolares dirigidas a la prevención de la obesidad en la población infantil comprendida entre los dos y doce años de edad.Método: Se trata de una revisión integradora de la literatura. La búsqueda de artículos se ha llevado a cabo entre diciembre de 2016 y febrero de 2017. Las búsquedas se han realizado en tres bases de datos: PubMed, Cochrane Plus y Cinhal. Resultados: Se han obtenido un total 17 artículos, 15 de ellos son ensayos clínicos y 2 revisiones sistemáticas. Se han incluido intervenciones de tipo educativo, dietético y deportivo, la intervención más repetida es la educativa.Conclusión: Las intervenciones han mejorado los estilos de vida de los niños, e incluso en ocasiones han logrado disminuir su peso.
Die Segmente des neuen Mittelverteilungsmodells der Universitätsbibliothek Potsdam: Die Verankerung von Zeitschriftenpaketverträgen und die Verstetigung von Open Access im Bibliotheksetat
Authors: Thomas Linda 
Published: July 2018

Zusammenfassung
Die Veränderungen im Bereich der Literaturerwerbung und -nutzung innerhalb der letzten sieben Jahre haben einen Neuentwurf des Mittelverteilungsmodells der Universitätsbibliothek Potsdam unumgänglich gemacht. Dieser gliedert sich klar in Segmente und verankert erstmals auch Open Access im Bibliotheksetat. Damit wird dem angestrebten Transformationsprozess Rechnung getragen.
Estradiol Drives the Anorexigenic Activity of Proopiomelanocortin Neurons in Female Mice
Authors: Stincic Todd L. , Grachev Pasha , Bosch Martha A. , Rønnekleiv Oline K. , Kelly Martin J. 
Published: July 2018

AbstractEnergy balance is regulated by anorexigenic proopiomelanocortin (POMC) and orexigenic neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons of the hypothalamic arcuate nucleus. POMC neurons make extensive projections and are thought to release both amino acid and peptide neurotransmitters. However, whether they communicate directly with NPY/AgRP neurons is debated. Initially, using single-cell RT-PCR, we determined that mouse POMCeGFPneurons expressSlc17a6(Vglut2) andSlc18a2(Vmat2), but notSlc31a1(Vgat) mRNA, suggesting glutamate and non-canonical GABA release. Quantitative (q)RT-PCR of POMCeGFPcells revealed thatVglut2andVmat2expression was significantly increased in E2- versus oil-treated, ovariectomized (OVX) female mice. Since 17β-estradiol (E2) is anorexigenic, we hypothesized that an underlying mechanism is enhancement of POMC signaling. Therefore, we optogenetically stimulated POMC neurons in hypothalamic slices to examine evoked release of neurotransmitters onto NPY/AgRP neurons. Using brief light pulses, we primarily observed glutamatergic currents and, based on the paired pulse ratio (PPR), determined that release probability was higher in E2- versus oil-treated, OVX female, congruent with increasedVlgut2expression. Moreover, bath perfusion of the Gq-coupled membrane estrogen receptor (ER) agonist STX recapitulated the effects of E2 treatment. In addition, high-frequency (20 Hz) stimulation generated a slow outward current that reversed near Ek+and was antagonized by naloxone, indicative of β-endorphin release. Furthermore, individual NPY/AgRP neurons were found to expressOprm1, the transcript for μ-opioid receptor, and DAMGO, a selective agonist, elicited an outward current. Therefore, POMC excitability and neurotransmission are enhanced by E2, which would facilitate decreased food consumption through marked inhibition of NPY/AgRP neurons.
Two Sides of the Same Coin: Distinct Sub-Bands in the α Rhythm Reflect Facilitation and Suppression Mechanisms during Auditory Anticipatory Attention
Authors: ElShafei Hesham A. , Bouet Romain , Bertrand Olivier , Bidet-Caulet Aurélie 
Published: July 2018

AbstractAnticipatory attention results in enhanced response to task-relevant stimulus, and reduced processing of unattended input, suggesting the deployment of distinct facilitatory and suppressive mechanisms. α Oscillations are a suitable candidate for supporting these mechanisms. We aimed to examine the role of α oscillations, with a special focus on peak frequencies, in facilitatory and suppressive mechanisms during auditory anticipation, within the auditory and visual regions. Magnetoencephalographic (MEG) data were collected from fourteen healthy young human adults (eight female) performing an auditory task in which spatial attention to sounds was manipulated by visual cues, either informative or not of the target side. By incorporating uninformative cues, we could delineate facilitating and suppressive mechanisms. During anticipation of a visually-cued auditory target, we observed a decrease in α power around 9 Hz in the auditory cortices; and an increase around 13 Hz in the visual regions. Only this power increase in high α significantly correlated with behavior. Importantly, within the right auditory cortex, we showed a larger increase in high α power when attending an ipsilateral sound; and a stronger decrease in low α power when attending a contralateral sound. In summary, we found facilitatory and suppressive attentional mechanisms with distinct timing in task-relevant and task-irrelevant brain areas, differentially correlated to behavior and supported by distinct α sub-bands. We provide new insight into the role of the α peak-frequency by showing that anticipatory attention is supported by distinct facilitatory and suppressive mechanisms, mediated in different low and high sub-bands of the α rhythm, respectively.
Visual and Hearing Impairments After Preterm Birth
Authors: Hirvonen Mikko , Ojala Riitta , Korhonen Päivi , Haataja Paula , Eriksson Kai , Gissler Mika , Luukkaala Tiina , Tammela Outi 
Published: July 2018

OBJECTIVES:
Our aim was to determine and compare the incidences of sensory impairments among very preterm (VP) (&lt;32 + 0/7 weeks), moderately preterm (MP) (32 + 0/7–33 + 6/7 weeks), late preterm (LP) (34 + 0/7–36 + 6/7 weeks), and term infants (≥37 weeks) and to establish risk factors of neurosensory disabilities.

METHODS:
This national register study included all live-born infants in Finland between 1991 and 2008. Infants who died before the age of 1 year, who had any major congenital anomaly, or had missing data were excluded (n = 21 007; 2.0%). A total of 1 018 256 infants were analyzed. Incidences of hearing loss, visual disturbances or blindness, other ophthalmologic disorders, and retinopathy of prematurity were determined for gestational age (GA) groups. Risk factors of hearing loss and visual disturbances or blindness were analyzed.

RESULTS:
The incidences of sensory impairments decreased with advancing GA at birth (P &lt; .001). The most prominent factors associated with increased risks of hearing loss and visual impairment were intracranial hemorrhage and convulsions. VP (odds ratio [OR] 2.34; 95% confidence interval [CI] 1.75–3.14) and LP (OR 1.26; 95% CI 1.04–1.52) births were associated with an increased risk of hearing loss, and VP (OR 1.94; 95% CI 1.55–2.44), MP (OR 1.42; 95% CI 1.11–1.80), and LP (OR 1.31; 95% CI 1.16–1.49) births predicted an increased risk of visual impairment.

CONCLUSIONS:
Incidences of sensory impairment decreased with increasing GA at birth. The most prominent risk factors predictive of sensory disabilities were intracranial hemorrhage and convulsions. VP and LP births were associated with an increased risk of hearing loss, and VP, MP, and LP births were associated with an increased risk of visual impairment.
Adjuvant Subcutaneous Trastuzumab for HER2-Positive Early Breast Cancer: Subgroup Analyses of Safety and Active Medical Conditions by Body Weight in the SafeHer Phase III Study
Authors: Jung Kyung Hae , Ataseven Beyhan , Verrill Mark , Pivot Xavier , De Laurentiis Michelino , Al-Sakaff Nedal , Lauer Sabine , Shing Mona , Gligorov Joseph , Azim Hamdy A. 
Published: July 2018

Abstract

Background
This SafeHer subgroup analysis assessed the safety of fixed-dose subcutaneous trastuzumab (H SC) as an adjuvant therapy in HER2-positive early breast cancer (EBC) by body weight.

Patients and Methods
Patients with HER2-positive EBC not previously treated with anti-HER2 therapy received H SC 600 mg (every 3 weeks for 18 cycles), with neoadjuvant or adjuvant chemotherapy or without adjuvant chemotherapy. Adverse events (AEs) were assessed throughout treatment and at final follow-up (28 ±5 days after last treatment). Subgroups were categorized by body weight, Asian origin, and chemotherapy administration. All analyses were descriptive.

Results
Of 2,577 patients enrolled, 2,573 received ≥1 dose of study medication and were included in this safety analysis. Median body weight at baseline was 67.0 kg (range 33.6–150.0 kg). Any-grade AEs occurred in 88.7% (2,282/2,573) of the overall population, versus 87.1% (590/677) of the lowest bodyweight quartile (≤59 kg), 90.0% (561/623) of the highest quartile (&gt;77 kg), and 86.5% (327/378) of the Asian population. Grade ≥3 AEs occurred in 23.2% (596/2,573) of the overall population, 17.9% (121/677) of the lowest bodyweight quartile, 26.8% (167/623) of the highest quartile, and 15.3% (58/378) of the Asian population. The highest bodyweight quartile had the highest incidence of medical conditions at baseline (highest quartile, 75.6%; lowest quartile, 56.1%).

Conclusion
These data support the use of fixed-dose H SC as an adjuvant therapy in HER2-positive EBC and confirm the comparable safety profile of H SC in patients with low body weight or of Asian origin versus the overall population in SafeHer. ClinicalTrials.gov: NCT01566721.

Implications for Practice
The safety profile of fixed-dose subcutaneous trastuzumab (H SC) was comparable between patients in the lowest bodyweight subgroup and the overall patient population, and also between patients of Asian origin (of whom a higher proportion often fall within the lower bodyweight quartiles) and the overall population. The safety data from this SafeHer subgroup analysis therefore support the use of fixed-dose H SC 600 mg administered every 3 weeks as an adjuvant therapy for patients with HER2-positive early breast cancer across different bodyweight subgroups and in the Asian patient population.