bluuebunny/crossref_metadata_2025_split huggingface dataset:
HDAC2, HDAC4, HDAC5, HDAC7, HDAC8, HDAC9 Gen İfade Seviyelerinin Çocukluk Çağı Akut Lösemilerinde Prognoz İle İlişkisi
Authors: Akın Balı Dilara , Kürekçi Ahmet Emin , Akar Mehmet Nejat 
Published: August 2018

Amaç: Histon deasetilazların değişmiş ifadesi hematolojik
maligniteler için kanser tedavisinde hedef olabilecek niteliktedir. HDAC
mutasyonları ve anormal ifade seviyeleri çeşitli kanser tiplerinde ve özellikle
hematolojik malignitelerde sıklıkla görülmekte olduğu, çocukluk çağı lösemi
örneklerinde HDAC2, HDAC3, HDAC6, HDAC7 ve HDAC8 gen ifadelerinin sağlıklı
çocuk kemik iliği örneklerine göre önemli derece yüksek olduğu rapor
edilmiştir. Gereç ve
Yöntem: Çalışmamızda 6 HDAC geninin gen
ifade profilini çocukluk çağı akut lösemisinde kantitatif Real Time PCR yöntemi
kullanılması ile tedavinin farklı zamanlarında belirlenmesi gerçekleştirilmiştir.
Bulgular: Çalışmamız sonucunda çocukluk çağı lösemi örneklerinde
HDAC genleri ifade seviyelerinin birbirine göre farklılık gösterdiği
gözlenmiştir. Çalışmamızda; tedavi öncesinde, kontrol örneklerinin ifadelenme
seviyelerine göre; HDAC2 ve HDAC9 ifadelenme seviyelerinin düşük, HDAC 4 ve
HDAC 8 eşit seviyede ve son olarak HDAC 5 ve HDAC7 yüksek olduğu
belirlenmiştir. Tedavi sonrasında ise,
kontrol örneklerinin ifadelenme seviyelerine göre; HDAC2 ve HDAC9
ifadelenme seviyelerinin düşük, HDAC 4 ve HDAC 8 yükseldiği ve HDAC 5 ve HDAC7’nin
ise düştüğü tespit edilmiştir. Sonuçlar: Tümor
gelişiminde rol oynayan genlerin ve/veya yolakları kontrol eden HDAC gen
seviyelerinin artması, tedavi sonrasında ise bu ifadelenme seviyelerinin sağlıklı
örneklerin seviyesine eşit olması, HDAC genlerinin kanser patogenezi ile direkt
ilişkide olabileceğini düşündürmektedir.
PUBLIC OPINION ON RELIGIOUS PRIVILEGES IN THE REPUBLICS OF THE NORTH CAUCASIAN FEDERAL DISTRICT OF THE RUSSIAN FEDERATION: ETHNICSOCIOLOGICAL ANALYSIS
Authors: KORNIENKO N. V. 
Published: August 2018

The article is based on materials of ethnic-sociological research conducted in 2016 on the territory of the republic of the North Caucasus Federal District of the Russian Federation: Republic of North Ossetia-Alania, Chechen Republic, Karachay-Cherkess Republic, Republic of Ingushetia, Republic of Dagestan, Kabardino- Balkarian Republic. The survey involved 1200 respondents - 200 people from each republic. The article analyzes the question of the validity of granting state and legal privileges of religious organizations. Respondents were asked to express their opinion about granting the state privileges only to the Russian Orthodox Church; only Islam - the most popular religion in the religion; only three traditional religions of Russia (Orthodoxy, Islam, Buddhism); granting equal rights to all religions or depriving all religions of any privilege. The author comes to the conclusion about almost complete unanimity in the issues of granting religious privileges to the inhabitants of the region - regardless of their religious affiliation, people want equal rights for all religions, they are less willing to grant rights only for all religions. All groups unanimously denied the rights of the privileges of the Russian Orthodox Church, Islam was also unwilling to grant rights to all groups except Chechens, but this option is far inferior to equal treatment of the three traditional or all religions.
INTERDISCIPLINARITY AND POLYFUNCTIONALITY IN THE SYSTEM OF CONCEPTS OF MODERN SCIENCE (BASED ON THE TERMS OF SOCIOLINGUISTICS, SOCIOLOGY, AND LINGUISTICS)
Authors: NEMYKA A. A. , SYTINA A. V. 
Published: August 2018

The article is devoted to the study of the peculiarities of realization of important properties of interdisciplinarity and polyfunctionality within the framework of the modern scientific conceptual paradigm. The study is based on the material of units functioning mainly within the term systems of sociolinguistics, sociology and linguistics. The relevance of the topic is due to the lack of development in modern science of the issues of systematic research of interdisciplinary integrative specificity of terminological usage. At the moment, we have accumulated a rich experience of describing languages of different Sciences, including new ones, which form their conceptual paradigm. However, researchers have so far not paid enough attention to such aspects of the terminology as its usual and specific features in the field of the existence of new scientific directions. The problem also lies in the fact that modern conceptual systems of sociolinguistics, sociology and linguistics are characterized by a number of specific features that manifest themselves in the field of their semantic connections and functional features. And if scientific research has already been created in relation to many terms, then in relation to the special units of these areas of such studies there is still not enough quantity for the problem to be considered resolved, reasoned and proven. The article cites the opinions of scientists, based on the provisions of modern methodology and terminology theory and practice. Based on such a study of the material, conclusions are drawn about the constitutive parameters of the terminological discourse under investigation.
LIMITATIONS OF DEVELOPMENT OF SOCIAL PARTNERSHIP OF POWER AND LOCAL COMMUNITY IN MODERN RUSSIAN CONDITIONS
Authors: ROGACH O. V. , MEDVEDEVA N. V. , FROLOVA E. V. 
Published: August 2018

The formation and development of partnerships between the authorities and society in the process of selecting strategic guidelines for social development have recently become the top priorities for many states. Modern trends and transformations of management practices actualize the use of social partnership technology in solving problems of social and economic development of the territories. The novelty of the material presented in the article is revealed in the analysis of the limitations of the formation and development of social partnership in contemporary Russian conditions, the results of which allow a fresh look at the causes and factors initiating a high level of alienation of the population from local self-government. The results of the expert survey allowed us to uncover the conditions for the formation of social partnership at the new institutional level in the context of building a constructive dialogue between local authorities and the population. It is concluded that institutional changes should be focused on strengthening the functions of strategic management, the formation of investment orientation of local authorities, ensuring the real autonomy of local government.
REVIEW OF: SHAPAROVA A.K. POLITICAL REPRESSION OF CIRCASSIANS IN THE NORTH CAUCASUS (1918 - 1940S). HISTORICAL AND ARCHIVAL MATERIALS AND MEMOIRS. NALCHIK: IGI KBSC RAS, 2027. 824 P. CIRCULATION 500 COPIES
Authors: BUGAI N. F. 
Published: August 2018

In the reviewed narrative, a thorough analysis of the book offered to the reader is made. For the first time in Russian historiography and as an author, and at the same time, the compiler A.K. Shaparova draws attention to the collective name of representatives of various Circassian communities living in the North Caucasus - Kabardians, Adygeyan ethnic communities, etc. Turning to such a complex problem as forced resettlement of peoples on the territory of Russia, the USSR, the author focuses on the Circassians. For a long period she was engaged in the identification and generalization of materials and documents on the life of Circassian communities in the study area in the chronological framework of the 1930s-1940s, specifically revealing many of the historical portraits of Circassians. And it concerns exclusively the peoples of the North Caucasus until 1917 and as an independent period after 1917, under the conditions of Soviet power. Of particular interest is the period until the early 1920s, which was associated with various kinds of transformations of society that had to be overcome by new state autonomous entities. In fact, the independent period is also the 1940s, when the mechanism of interethnic relations in the state was actively involved in practice as forced resettlement. It universally acted as a kind of management of peoples and citizens. It often resorted to the authorities as before 1917, and in the Soviet period. The book is intended for a wide range of readers that have the opportunity to significantly expand their knowledge on this complex issue of the history of the peoples of Russia, the USSR, about the complex process when such a method of managing many aspects of interethnic relations as forced relocations was actively involved. The book is read with great interest.
REVOLUTION FROM THE RIGHT: THE RUSSIAN BLACK HUNDREDS MOVEMENT AND ITS PLACE IN THE HISTORY OF EUROPEAN FAR RIGHT PARTIES AND MOVEMENTS Part II-I: the Black Hundred understanding of Russianness in the general European context of the history of nationalism and the consolidation of nations: origins and development of varieties of nationalism in the Russian Empire and Europe
Authors: ROCCHI T. 
Published: August 2018

This series of articles investigates the Black Hundreds’ understanding of Russianness in the general European context of the history of nationalism. In brief, Russianness is the totality of nationally specific characteristics that define Russians as Russians and that distinguish Russians from other peoples. Through Russianness, according to the Black Hundreds, Russians should form a cohesive, selfidentifying community united in loyalty to the triple formula “Orthodoxy, Autocracy, Nationality”. The Black Hundred understanding of Russianness strongly differed from the definition of Russianness by other Russian nationalists of the period. Several historians have noted that the Black Hundreds’ definition of a “true Russian” indicated not an ethnic but rather a political affiliation - loyalty to the triple formula “Orthodoxy, Autocracy, Nationality”. The Black Hundreds’ understanding of Russianness had contradictory applications. The Black Hundreds emphasized the allembracing nature of the Russian people and considered many members of the non-Russian peoples as members of the Russian nation. However, they also excluded entire categories of Russians from the ranks of the Russian people and divided the non-Russian peoples of the Empire into the categories of “friendly to Russia” and “hostile to Russia”. The Black Hundreds also often used eschatological themes of demonization of external and especially internal enemies of Russia and the Russian people. Note that the Black Hundreds followed general European trends in political eschatology. It is important to note that the debates about Russianness were an integral part of the general European process of the consolidation of both ethnic and political nations against the background of competing understandings of identity of individuals, groups, and societies. The articles will give a comparative analysis of the Black Hundreds’ concept of Russianness with the concepts of Frenchness in the French Revolution and Germanness in Nazi Germany. The articles’ theme has a huge contemporary relevance in light of debates about national identities and values in the Russian Federation and many European countries.
EVALUATION OF THE CONTRADICTIONS OF TRADITIONS AND INNOVATIONS IN THE SYSTEM OF HIGHER EDUCATION MANAGEMENT: SOCIOLOGICAL RESEARCH
Authors: IVANOVA O. A. 
Published: August 2018

The author in the article on the basis of the results of a specific sociological study shows the importance of traditions and innovations in the system of managing Russian higher education to ensure the educational security of the state in the conditions of the transition of the world economy to science-intensive technologies, the unification of legislation, and the integration of production. The technology of investigating the problem is presented on the basis of a complex of theoretical and empirical methods. The methodology of studying education as an open system in which traditions are subjected to destruction by the forces and means of a hybrid war is revealed. Possible threats, dangers, objectivity and subjectivity of the conflict of traditions and innovations in the management system of higher education are shown. The author substantiates the necessity to minimize the conflict by the organization of strategic management of the main institutions of the society. The shortcomings of our system of higher education management are revealed, which do not allow implementing the best practices of the Bologna process. The rationale for introducing innovations and preserving domestic traditions is presented. The ways of prevention of conflicts of traditions and innovations in the system of management of higher education in Russia are determined. The results of the study of the conflict of traditions and innovations in the system of management of Russian higher education showed that the introduction of Western educational innovations led to destructive conflicts. The main reasons for the contradictions between traditions and innovations are shown.
The role of obesity in the development of labor and postpartum abnormalities
Authors: Asakeeva R S , Kalkanbaeva Ch K , Zhalieva G K , Niyazova F R , Shoonaeva N Dzh 
Published: August 2018

Aim. Comparative assessment of the features of the course of labor and postpartum period in women with obesity of various classes.
Methods. During 2014-2016, a cohort retrospective and prospective study included 318 birth records. The main group consisted of 198 case records of women with different severity of obesity (122 with obesity class I, 57 with class II and 19 with class III), and the control group included 120 case records of women without obesity.
Results. In women with obesity class II and III (p=0.003 and p <0.001) had preterm birth more often than in the control group. Patients with obesity class III had the cesarean section significantly more often than in the control group (p=0.043), in the same group hypertensive disorders in labor and intrauterine hypoxia of the fetus developed more frequently (p=0.009 and p=0.039). In the postpartum period with class III obesity, postpartum haemorrhage was significantly more frequent than in the control group (p=0.045). Among complications of postpartum period in patients with obesity class II, a loychiometer (by 1.7 times), endometritis (by 1.6 times), complications after cesarean section (by 2.1 times) were registered more often than in the control group, and in obesity class III - subinvolution of the uterus (by 2.1 times), endometritis (by 2.4 times), complications after cesarean section (by 3.2 times), divergence of the seams on the perineum (by 2.4 times), but these parameters were not statistically significantly different.
Conclusion. The negative impact of excess body weight on the labor course was shown, moreover, labor in obesity class I is more favorable than in class II and III.
Influence of dental diseases of pregnant women on newborns’ health state
Authors: Prokhodnaya V A 
Published: August 2018

Aim. To study the connection between various dental diseases of inflammatory nature in pregnant women and body weight of newborns depending on the presence or absence of systemic inflammatory reaction in the mother's organism and severity of the main symptoms of periodontal lesions.
Methods. We examined 207 pregnant patients with tooth caries, 72 patients with gingivitis and 93 women with chronic generalized periodontitis, 31 healthy pregnant women with no dental and somatic pathology and no complications of gestational period. The dental status of the patients was studied in the third trimester of pregnancy (36-40 weeks of gestation). Body weight was measured in newborn babies from pregnant women with dental pathology and without it. In peripheral, umbilical and retroplacental blood, the concentration of the inflammatory mediator interleukin-6 was evaluated by enzyme-linked immunosorbent assay, and C-reactive protein was evaluated by latex immune turbidimetry.
Results. The decrease in weight of newborns from mothers suffering from chronic generalized periodontitis, is caused not only by severity of periodontal destruction but also by the course of the disease in pregnancy, damaged integrity and permeability of histochematic barrier, increased concentration of inflammatory mediators in the peripheral, umbilical and retroplacental blood. The risk of having a baby with low birth weight in women suffering from chronic generalized periodontitis with the depth of periodontal pockets is 6 mm, gingival bleeding during probing and increased concentration of systemic inflammatory mediators in peripheral circulation is extremely high and is 0.96.
Conclusion. In mothers suffering from severe gingivitis, moderate chronic generalized periodontitis during pregnancy in case of progressive course of chronic generalized periodontitis, the body weight of newborns is lower compared to body weight of newborns from healthy women without dental pathology.
Indicative role of membranolysis markers in the prognosis of uncomplicated community-acquired pneumonia in children of school age
Authors: Pikuza O I , Suleymanova Z Ya , Samorodnova E A , Zakirova A M 
Published: August 2018

Aim. To evaluate the indicative role of membranolysis markers in the prognosis of uncomplicated community-acquired pneumonia in school children and to establish its relation with zinc status indices.
Methods. The study included 229 children aged 7 to 17 years with community-acquired pneumonia. The patients were divided into three groups based on morphological form of lung involvement: focal (103 children - group 1), segmental (64 patients - group 2), and lobar pneumonia (62 subjects - group 3). The state of cell membranes was evaluated by the activity of 5’-nucleotidase and rate of sodium-lithium countertransport in erythrocyte membrane. Intensity of peroxidation processes was evaluated by the level of end toxic products and total antioxidative activity, and additionally the blood concentration of zinc was measured by atomic absorption spectrophotometry.
Results. Significant effect of membranolysis processes on the clinical course of pneumonia was revealed. The most prominent pathological changes of the studied indices were registered in patients with focal form of the disease (group 1): increase of the concentration of lipid peroxidation products in average to 5.4±0.06 umol/L and the level of 5’-nucleotidase to 233.90±9.15 nkat, decrease of serum level of zinc to 9.73±0.09 mmol/L and total antioxidative activity to 23.22±0.29%. It was associated with prolonged course and tendency to slow reversal of physical findings in the lungs compared to patients from groups 2 and 3 (p 0.05, respectively).
Conclusion. Damage of cytoplasmic membrane in the focus of inflammation can be an objective marker of the course of community-acquired pneumonia in children and a sensitive prognostic sign and can allow identifying children into groups of high risk of prolonged course.
Medical legal assessment of medical care for tick-borne encephalitis with lethal outcome
Authors: Spiridonov V A , Aleksandrova L G , Kalyanov V A , Latfullina R R 
Published: August 2018

Aim. Study of regulatory and legal base according to the criminal case file submitted for expert and medico-legal assessment of a case of failure of health care in tick-borne viral encephalitis in an endemic zone.
Methods. During the research, the expert and legal analysis was performed to establish the cause-and-effect relationship between health workers’ actions and lethal outcome of tick-borne viral encephalitis on the basis of standard and legal acts of the Russian Federation. Special authors’ attention was paid to the assessment of influence of quality of preventive measures organization concerning this viral infection.
Results. Features and possible defects were studied and revealed not only at a stage of diagnosis and treatment of patients with tick-borne encephalitis, but also when taking preventive measures, taking into account the operating standard and legal base. Based on the research results the algorithm of actions during an expert legal assessment of efficiency of health care in similar cases was offered.
Conclusion. The correct expert assessment of the revealed defects of health care is possible if overcoming all complexity of interpretation of epidemiological, clinical, laboratory and morphological data.
Cutaneous manifestations and systemic correlation in patients with lupus erythematosus and its subsets: a study of 40 cases
Authors: Mahajan Rashmi , Ninama Kishan , Pandya Ishan , Patel Rajvee , Bilimoria F. E. 
Published: August 2018

<p class="abstract"><strong>Background:</strong> The objective was to study various dermatological manifestations and clinical and laboratory features in patients of lupus erythematosus (LE) and its subsets.</p><p class="abstract"><strong>Methods:</strong> This is a cross sectional observational study done in a tertiary care hospital in a rural setup in Piparia, Ta. Waghodiya, Dist. Vadodara, Gujarat. All the patients with clinical features of LE and its subsets were included in the study over a period of 16 months and were subjected to detailed history taking, complete cutaneous and general examination and laboratory investigations.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of the 40 cases, 22 cases were systemic lupus erythematosus (SLE), 13 cases were discoid lupus erythematosus (DLE), four cases were of Rowell’s syndrome and one case was of mixed connective tissue disorder (MCTD). 97.5% of cases had cutaneous involvement, i.e. photosensitivity (77.5%), oral ulcers, hair loss and malar rash. Systemic symptoms and abnormal laboratory parameters were present in the cases of SLE, Rowell’s syndrome and MCTD, with hematological involvement being the most common in both SLE (77%) and Rowell’s syndrome (100%) and positive anti-nuclear antibody (ANA) titer being the most common abnormal laboratory finding in both SLE (95.4%) and Rowell’s syndrome (100%). The most commonly found antibody was anti-dsDNA (64.3%) in SLE and anti SS-A (100%) in Rowell’s syndrome.</p><p class="abstract"><strong>Conclusions:</strong> Cutaneous features though occasionally subtle, are pointers to a diagnosis of SLE. Hair loss, malar rash and photosensitivity alone or in association with altered hematologic/ANA profile are the key markers of the disease activity.</p><p> </p>
Water and Energy Nexus under Climate Change Scenarios: Lessons from Brazil
Authors: Júnior Wilson Cabral de Sousa 
Published: August 2018

AbstractThe water and energy nexus approach is a complex subject that involves diverse sectors and stakeholders, as well as temporal and spatial scales that are also diverse. When analyzing local or regional contexts, the approach may acquire specific interfaces. This article deals with the nexus of water and energy from the point of view of energy planning, inserting the context of climate change, and the dilemmas experienced in Brazil, related to the theme. It intends to bring to light such relations, for a reflection on the complexity of this narrative and the necessary arrangements for governance in this context. In the Brazilian case, the water and energy nexus is established primarily, since the electricity is mostly supplied by hydroelectric plants. As discussed in the paper, the expansion of hydroelectric plants in Brazil is reaching a limit, which will lead to the development of lower cost techniques in civil engineering and associated works, especially in arrangements of lower impact and greater efficiency. The climatic question also becomes relevant when analyzing the expansion of the electric system based on hydroelectricity, since this modal would be one of the most affected by climate changes, according to official projections. Therefore, knowledge of the water and energy nexus needs to be expanded in more detailed aspects, including edge and feedback effects, in addition to the incorporation of other relationships, and a systemic and integrative approach involving water and energy is needed to deal with issues associated with multiple uses and interdependencies.