bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecological and Control Studies of Musk Thistle
Authors: Feldman Israel , McCarty M. K. , Scifres C. J. 
Published: June 2019

Herbicides applied April 30, May 10, or October 14 gave best control of musk thistle (Carduus nutansL.). The most effective herbicide at all dates and rates was 4-amino-3,5,6-trichloropicolinic acid (picloram). Two lb/A of 2-methoxy-3,6-dichlorobenzoic acid (dicamba) also was effective at all spring dates. Two lb/A of 2,4-dichlorophenoxyacetic acid (2,4-D) resulted in excellent control of musk thistle when applied May 10 or October 14.More musk thistle seedlings became established in nongrazed, cool season grass pastures than in nongrazed, mixed warm season grass pastures. Greater germination was attributed to the reserve moisture and accumulation of litter which served as an excellent germination medium. However, only one musk thistle plant remained in the nongrazed pastures 1 year after seeding. The remainder of the seedlings and young rosettes found in the protected areas in 1965 had succumbed to the heavy competition by 1966.
Susceptibility of Annual Bluegrass and Turfgrasses to Bensulide and Three Uracil Herbicides
Authors: Neidlinger T. J. , Furtick W. R. , Goetze N. R. 
Published: June 2019

Golf putting greens were sprayed with N-(2-mercaptoethyl) benzenesulfonamide S-(O,O-diisopropyl phosphorodithioate) (bensulide). Creeping bentgrass (Agrostis palustris Huds.) and annual bluegrass (Poa annua L.) were observed for injury. Preemergence and postemergence treatments of 5-bromo-3-sec-butyl-6-methyluracil (bromacil), 5-chloro-3-tert-butyl-6-methyluracil (terbacil), and 5-bromo-3-tert-butyl-6-methyluracil (hereinafter referred to as DP 733) were applied to a prepared seedbed planted with Kentucky bluegrasses (Poa pratensis L., var. Merion and var. Newport) and annual bluegrass.Thirty lb/A of bensulide produced leaf discoloration and root length reduction of established annual bluegrass plants without injuring creeping bentgrass. Terbacil at 0.2 lb/A and bromacil at 0.4 lb/A gave highly selective control of annual bluegrass in Merion and Newport Kentucky bluegrasses when applied preemergence to the three grasses. Postemergence applications of these compounds produced moderate selective control of annual bluegrass.
Retroaortic innominate vein in a patient with transposition of the great arteries: the surgical implications
Authors: Breatnach Colm R. , Nolke Lars , McMahon Colin J. 
Published: June 2019

AbstractWe describe the case of a newborn infant with transposition of the great vessels and a retroaortic innominate vein. This is a previously undescribed association. The decision was made to incorporate the retroaortic innominate vein into the Lecompte procedure at the time of surgery to avoid the risk of superior caval vein syndrome.
The impact of tricuspid valve regurgitation severity on exercise capacity and cardiac-related hospitalisations among adults with non-operated Ebstein’s anomaly
Authors: Buber Jonathan , Vatury Ori , Klempfner Robert , Tejman-Yarden Shai 
Published: June 2019

AbstractBackground:Tricuspid valve regurgitation is an inherent part of Ebstein’s anomaly, yet whether the severity of the regurgitation further impairs exercise capacity and contributes to long-term morbidity on top of the lesion severity per se is unknown.Methods:To evaluate for this potential effect, we included 30 patients with Ebstein’s anomaly who did not undergo any form of surgical interventions and had a cardiopulmonary exercise test and echocardiographic studies in this retrospective analysis. Echocardiographic studies and cardiopulmonary exercise tests were critically reviewed for lesion severity grade, tricuspid regurgitation degree, and exercise parameters. Cardiac-related hospitalisations were recorded from computerised medical records and during clinic visits.Results:Fourteen patients (47%) had moderate and 8 (27%) had severe regurgitation. Patients with ≥ moderate regurgitation exhibited significantly lower exercise capacity (median % predicted maximal oxygen consumption, 62 versus 79%, p = 0.03) and venilatory efficiency at exercise. When stratifying exercise results by regurgitation degree, a stepwise decrease in oxygen consumption and ventilatory efficiency with increasing regurgitation severity was observed, regardless of the anatomic lesion severity. During a median follow-up of 4.6 years, > moderate tricuspid regurgitation was associated with significantly lower cumulative probability of freedom from cardiac hospitalisations.Conclusions:We report that among non-operated Ebstein’s anomaly patients, greater tricuspid regurgitation severity was associated with worse exercise capacity and with overall higher probability of cardiac-related hospitalisations independent from the underlying lesion severity.
Skinfold thickness and the incidence of type 2 diabetes mellitus and hypertension: an analysis of the PERU MIGRANT study
Authors: Ruiz-Alejos Andrea , Carrillo-Larco Rodrigo M , Miranda J Jaime , Gilman Robert H , Smeeth Liam , Bernabé-Ortiz Antonio 
Published: June 2019

AbstractObjective:To determine the association between excess body fat, assessed by skinfold thickness, and the incidence of type 2 diabetes mellitus (T2DM) and hypertension (HT).Design:Data from the ongoing PERU MIGRANT Study were analysed. The outcomes were T2DM and HT, and the exposure was skinfold thickness measured in bicipital, tricipital, subscapular and suprailiac areas. The Durnin–Womersley formula and SIRI equation were used for body fat percentage estimation. Risk ratios and population attributable fractions (PAF) were calculated using Poisson regression.Setting:Rural (Ayacucho) and urban shantytown district (San Juan de Miraflores, Lima) in Peru.Participants:Adults (n988) aged ≥30 years (rural, rural-to-urban migrants, urban) completed the baseline study. A total of 785 and 690 were included in T2DM and HT incidence analysis, respectively.Results:At baseline, age mean was 48·0 (sd12·0) years and 47 % were males. For T2DM, in 7·6 (sd1·3) years, sixty-one new cases were identified, overall incidence of 1·0 (95 % CI 0·8, 1·3) per 100 person-years. Bicipital and subscapular skinfolds were associated with 2·8-fold and 6·4-fold risk of developing T2DM. On the other hand, in 6·5 (sd2·5) years, overall incidence of HT was 2·6 (95 % CI 2·2, 3·1) per 100 person-years. Subscapular and overall fat obesity were associated with 2·4- and 2·9-fold risk for developing HT. The PAF for subscapular skinfold was 73·6 and 39·2 % for T2DM and HT, respectively.Conclusions:We found a strong association between subscapular skinfold thickness and developing T2DM and HT. Skinfold assessment can be a laboratory-free strategy to identify high-risk HT and T2DM cases.
Mythic forecasts: researcher portrayals of extraterrestrial life discovery
Authors: Nelson John P. 
Published: June 2019

AbstractScientific discovery, especially at the boundaries of human observational capacity, is an extended, incremental and sometimes controversy-laden process; but practicing researchers' published statements do not always portray it as such. If extraterrestrial life (ETL) exists, and if we find it, the process of observation, interpretation, understanding and confirmation may take decades. Though it is, thus, likely that scientific consensus will accrue around an ETL interpretation in a gradual and subtle process, the general public and even practicing scientists often discuss ETL discovery as though it will be rapid and dramatic. To illustrate this phenomenon, this review analyses a convenience sample of astronomers', astrobiologists' and astrosociologists' statements and assumptions in scholarly and general-audience media regarding a prospective discovery of ETL. Of 30 surveyed scholarly studies and 37 surveyed general-audience pieces, 24 scholarly and scientists' perspectives in 32 general-audience pieces do not acknowledge the extended nature of scientific discovery; and only three and four, respectively, do so explicitly. These results suggest that ETL researchers' statements could often portray an inaccurate or at least atypical vision of scientific progress in their own studies and to general-audience media outlets.
Real-world outcomes of endovascular treatment in a non-selected	population with peripheral artery disease – prospective study with 2-year	follow-up
Authors: Schulte Karl-Ludwig , Hardung David , Tiefenbacher Christiane , Weiss Thomas , Hoffmann Ulrich , Amendt Klaus , Tepe Gunnar , Heuser Lothar , Treszl Andras , Lau Hans-Joachim , Pfannebecker Thomas , Wegscheider Karl 
Published: June 2019

Summary. Background: The study aimed to evaluate the outcomes of percutaneous transluminal angioplasty (PTA) in lower-extremity peripheral artery disease (PAD) patients. Patients and methods: A multi-centre, observational study was performed with 32 German and Austrian centres contributing data to the PTA registry. Data of 1,781 patients with lower-leg and pelvic PAD who were suitable for endovascular PTA treatment were contributed from participating centres. Data from 1,533 patients are reported here (1,055 male and 478 female). This study did not have exclusion criteria. Quality of life (QOL) questionnaire (EQ-5D) scores, Rutherford classification, mortality, patency rate and details of major adverse cardiovascular events were collected at 6-, 12-, 18-, and 24-month follow ups. Results: PTA with/without stenting achieved 90.3 %, 86.5 %, 82.7 %, and 71.9 % technical success (recanalisation achieving ≥ 70 % patency, no evidence of embolisation, recoiling or dissection) in iliac, femoral, popliteal, and below-the-knee arteries, respectively. Procedural/postprocedural complications occurred in 142 (9.3 %, 1 death) and 74 (4.8 %) patients. QOL, mobility, self-care, activity, and pain/discomfort scores improved (p < 0.01), anxiety/depression was insignificantly improved. During follow-up, 409 (26.7 %) patients were hospitalised for PAD, 281 (18.3 %) required reintervention, and 145 (9.5 %) died or needed amputation (n = 49; 3.2 %). Multivariate analysis demonstrated poorer outcomes in patients with comorbidities. Conclusions: PTA with/without stenting is effective, safe, and widely applicable, with few complications. It improves QOL, but not anxiety/depression.
Modeling Snow Failure Behavior and Concurrent Acoustic Emissions Signatures With a Fiber Bundle Model
Authors: Capelli A. , Reiweger I. , Schweizer J. 
Published: June 2019

AbstractSnow failure is the result of gradual damage accumulation culminating in macroscopic cracks. The failure type strongly depends on the rate of the applied load or strain. Our aim was to study the microstructural mechanisms leading to the macroscopic loading rate dependence. We modeled snow failure and the concurrent acoustic emissions for different loading rates with a fiber bundle model and compared the model results to laboratory experiments. The fiber bundle model included two time‐dependent healing mechanisms opposing the loading‐induced damage process: (a) sintering of broken fibers and (b) relaxation of load inhomogeneities due to viscous deformation. The experimental acoustic emissions features could only be reproduced correctly if both healing mechanisms were included in the model. We conclude that both sintering and viscous deformation at a microscopic level essentially contribute to the macroscopic loading‐ and strain‐rate dependent behavior of snow.
Inductively coupled, mm-sized, single channel optical neuro-stimulator with intensity enhancer
Authors: Khan Wasif , Jia Yaoyao , Madi Fatma , Weber Arthur , Ghovanloo Maysam , Li Wen 
Published: June 2019

AbstractWe introduce a single channel neuro-stimulator consisting of a reflector-coupled microscale light emitting diode (µLED) with an integrated mm-sized wireless receiver (Rx) coil for free-floating, battery-free, untethered optogenetics neuromodulation. The system utilizes a two-coil inductive link to deliver instantaneous power at a low operating frequency (<100 MHz) for continuous optical stimulation with minimized invasiveness and tissue exposure to electromagnetic radiation. Coupling a microscale reflector to the µLED provides significant light intensity enhancement compared to a bare µLED. Our activated stimulators have an operational temperature increase of <1 °C, well below the safety limit of biomedical implants. In vivo experiment and histological analysis verify the efficacy of wireless optical stimulation in the primary visual cortex of rats, using c-Fos biomarker as a reporter of light-evoked neuronal activity.
Acoustofluidic separation of cells and particles
Authors: Wu Mengxi , Ozcelik Adem , Rufo Joseph , Wang Zeyu , Fang Rui , Jun Huang Tony 
Published: June 2019

AbstractAcoustofluidics, the integration of acoustics and microfluidics, is a rapidly growing research field that is addressing challenges in biology, medicine, chemistry, engineering, and physics. In particular, acoustofluidic separation of biological targets from complex fluids has proven to be a powerful tool due to the label-free, biocompatible, and contact-free nature of the technology. By carefully designing and tuning the applied acoustic field, cells and other bioparticles can be isolated with high yield, purity, and biocompatibility. Recent advances in acoustofluidics, such as the development of automated, point-of-care devices for isolating sub-micron bioparticles, address many of the limitations of conventional separation tools. More importantly, advances in the research lab are quickly being adopted to solve clinical problems. In this review article, we discuss working principles of acoustofluidic separation, compare different approaches of acoustofluidic separation, and provide a synopsis of how it is being applied in both traditional applications, such as blood component separation, cell washing, and fluorescence activated cell sorting, as well as emerging applications, including circulating tumor cell and exosome isolation.
Assessment of vitamin D status and parathyroid hormone during a combined intervention for the treatment of childhood obesity
Authors: Durá-Travé Teodoro , Gallinas-Victoriano Fidel , Chueca-Guindulain María Jesús , Berrade-Zubiri Sara , Urretavizcaya-Martinez María , Ahmed-Mohamed Lotfi 
Published: June 2019

Abstract
Background
Obesity is associated with vitamin D deficiency. The aim of this work is to analyze the changes in vitamin D status and PTH levels in a group of children with obesity receiving combined intervention program in order to get BMI status reduction.

Methods
Longitudinal study in 119 children with obesity, aged 9.1–13.9 years, included in a 1-year combined dietary-behavioral-physical activity intervention. Anthropometric measurements (weight, height, BMI and fat mass index) were registered every 3 months and blood testing (calcium, phosphorous, 25(OH)D and PTH) were collected at the beginning and after 12 months of follow-up. A control group was recruited (300 healthy children, aged 8.1–13.9 years). The criteria of the US Endocrine Society were used for the definition of hypovitaminosis D.

Results
Vitamin D deficiency was significantly higher in obesity group (31.1 vs. 14%). There was negative correlation between 25(OH)D and fat mass index (r = −0.361, p = 0.001). Patients with BMI reduction throughout combined intervention were 52 (43.7%). There was a significant increase in the prevalence of hypovitaminosis D in patients without BMI reduction at the end of follow-up, but in those patients with BMI reduction there was no changes of vitamin D status.

Conclusions
Obesity increases the prevalence of suboptimal vitamin D status, and a BMI status reduction in children with obesity may be required to at least stabilize vitamin D status.
The reduction of astrocytes and brain volume loss in anorexia nervosa—the impact of starvation and refeeding in a rodent model
Authors: Frintrop Linda , Trinh Stefanie , Liesbrock Johanna , Leunissen Christina , Kempermann Julia , Etdöger Serhat , Kas Martien J. , Tolba René , Heussen Nicole , Neulen Joseph , Konrad Kerstin , Päfgen Vera , Kiessling Fabian , Herpertz-Dahlmann Beate , Beyer Cordian , Seitz Jochen 
Published: June 2019

AbstractAnorexia nervosa (AN) is an often chronic, difficult to treat illness that leads to brain volume reductions in gray and white matter. The underlying pathophysiology is poorly understood, despite its potential importance in explaining the neuropsychological deficits and clinical symptoms associated with the illness. We used the activity-based anorexia model (ABA), which includes food reduction and running wheel access in female rats to study brain changes after starvation and refeeding. Longitudinal animal MRI and post-mortem brain sections confirmed a reduction in the mean brain volumes of ABA animals compared to controls. In addition, the mean number of astrocytes was reduced by over 50% in the cerebral cortex and corpus callosum, while the mean number of neurons was unchanged. Furthermore, mean astrocytic GFAP mRNA expression was similarly reduced in the ABA animals, as was the mean cell proliferation rate, whereas the mean apoptosis rate did not increase. After refeeding, the starvation-induced effects were almost completely reversed. The observation of the astrocyte reduction in our AN animal model is an important new finding that could help explain starvation-induced neuropsychological changes in patients with AN. Astrocyte-targeted research and interventions could become a new focus for both AN research and therapy.
Curcumin induced oxidative stress causes autophagy and apoptosis in bovine leucocytes transformed by Theileria annulata
Authors: Araveti Prasanna Babu , Srivastava Anand 
Published: June 2019

AbstractBovine tropical theileriosis is a tick-borne disease, caused by Theileria annulata which is a protozoan parasite that resides within the B-cells and macrophages. T. annulata is a unique parasite that can transform bovine leucocytes which leads to the cancer hallmarks in the infected cells. Previously, curcumin has been shown to possess multiple pharmacological activities such as anti-inflammatory and anti-cancer activities. In this study, we demonstrated that curcumin inhibits the proliferation of Theileria-transformed bovine leucocytes by promoting apoptosis and autophagy. The transcriptome analysis of curcumin treated cells showed that the genes involved in cell death and autophagy are also differentially regulated. We further elucidated the mechanism of action of curcumin on Theileria infected bovine cells. We found that curcumin induced the generation of reactive oxygen species (ROS) which activated caspase 8 and destabilized the mitochondrial membrane potential leading to the release of cytochrome c from mitochondria. This subsequently led to the activation of caspase 3 and PARP cleavage, finally leading to apoptosis in the infected cells. Furthermore, curcumin induced the process of autophagy which was characterized by the formation of acidic vesicular organelles, LC3B accumulation with lysosome inhibitor, E64d, and the presence of autophagosomes as visualized by transmission electron microscopy (TEM). Curcumin treatment suppressed the mTOR and increased the expression of autophagy-related proteins. We also found that N- acetylcysteine, an inhibitor of ROS, could rescue the infected cells from curcumin induced apoptosis and autophagy mediated cell death. Intriguingly, curcumin had no effect on uninfected bovine PBMCs. Altogether, these data suggest the therapeutic potential of curcumin against bovine tropical theileriosis.
Realization of wafer-scale nanogratings with sub-50 nm period through vacancy epitaxy
Authors: Huang Qiushi , jia Qi , Feng Jiangtao , Huang Hao , Yang Xiaowei , Grenzer Joerg , Huang Kai , Zhang Shibing , Lin Jiajie , Zhou Hongyan , You Tiangui , Yu Wenjie , Facsko Stefan , Jonnard Philippe , Wu Meiyi , Giglia Angelo , Zhang Zhong , Liu Zhi , Wang Zhanshan , Wang Xi , Ou Xin 
Published: June 2019

AbstractGratings, one of the most important energy dispersive devices, are the fundamental building blocks for the majority of optical and optoelectronic systems. The grating period is the key parameter that limits the dispersion and resolution of the system. With the rapid development of large X-ray science facilities, gratings with periodicities below 50 nm are in urgent need for the development of ultrahigh-resolution X-ray spectroscopy. However, the wafer-scale fabrication of nanogratings through conventional patterning methods is difficult. Herein, we report a maskless and high-throughput method to generate wafer-scale, multilayer gratings with period in the sub-50 nm range. They are fabricated by a vacancy epitaxy process and coated with X-ray multilayers, which demonstrate extremely large angular dispersion at approximately 90 eV and 270 eV. The developed new method has great potential to produce ultrahigh line density multilayer gratings that can pave the way to cutting edge high-resolution spectroscopy and other X-ray applications.
Exceptional fracture resistance of ultrathin metallic glass films due to an intrinsic size effect
Authors: Glushko Oleksandr , Mühlbacher Marlene , Gammer Christoph , Cordill Megan J. , Mitterer Christian , Eckert Jürgen 
Published: June 2019

AbstractMetallic glasses typically fail in a brittle manner through shear band propagation but can exhibit significant ductility when the sample size is reduced below a few hundreds of nanometers. To date the size effect was mainly demonstrated for free-standing samples and the role of extrinsic setup parameters on the observed behavior is still under debate. Therefore, in the present work we investigated the mechanical properties of polymer-supported sputtered amorphous Pd82Si18 thin films with various thicknesses. We show that the films exhibit brittle fracture for thicknesses far below 100 nm. A pronounced size effect resulting in extended crack-free deformation up to 6% strain was observed only in films as thin as 7 nm – a thickness which is lower than the typical shear band thickness. This size effect results in exceptional cyclic reliability of ultrathin metallic glass films which can sustain cyclic strains of 3% up to at least 30,000 cycles without any indication of fatigue damage or electrical conductivity degradation. Since the enhancement of mechanical properties is observed at ambient conditions using inexpensive substrates and an industrially scalable sputter deposition technique, a new research avenue for utilization of ultrathin metallic glasses in microelectronics, flexible electronics or nanoelectromechanical devices is opened up.