bluuebunny/crossref_metadata_2025_split huggingface dataset:
What is the clinical utility of acoustic and vibrational analyses in uncemented total hip arthroplasty?
Authors: Patel Shlok , Hecht Christian J. , Homma Yasuhiro , Kamath Atul F. 
Published: December 2024

Abstract
Background
Despite recent developments in THA, a more objective method is needed to assist orthopedic surgeons in identifying the insertion endpoint of the broaching procedure. Therefore, this systematic review evaluated the in-vivo efficacy of various acoustic and vibration analyses in detecting proper implant seating, identifying intraoperative complications, and quantifying the accuracy of predictive modeling using acoustics.

Methods
Four electronic databases were searched on July 23rd, 2023, to retrieve articles evaluating the use of acoustic analysis during THA. The search identified 835 unique articles, which were subsequently screened by two independent reviewers as per our inclusion and exclusion criteria. In total, 12 studies evaluating 580 THAs were found to satisfy our criteria and were included in this review.

Results
Methodologically, analyses have suggested stopping broaching when consecutive blows emit similar acoustic profiles (maximum peak frequency ± 0.5 kHz), which indicates proper implant seating in terms of stability and mitigates subsidence. Also, abrupt large deviations from the typical progression of acoustic signals while broaching are indicative of an intraoperative fracture. Since height, weight, femoral morphological parameters, and implant type have been shown to alter acoustic emissions while hammering, incorporating these factors into models to predict subsidence or intraoperative fracture yielded virtually 100% accuracy in identifying these adverse events.

Conclusion
These findings support that acoustic analyses during THA show promise as an accurate, objective, and non-invasive method to predict and detect proper implant fixation as well as to identify intraoperative fractures.

Trial registration
PROSPERO registration of the study protocol: CRD42023447889, 23 July 2023.
The value of misoprostol administration before intrauterine contraceptive device insertion: a systematic review and meta-analysis
Authors: Maged Ahmed M. , El-Goly Nour A. , Bassiouny Nehal , El-Demiry Nihal , AbdelAziz Suzi 
Published: December 2024

Abstract
Objectives
To assess the value of misoprostol administration before IUD insertion.

Search strategy
Screening of PubMed, Scopus, Web Of Science, ScienceDirect, and clinical trials registry till April 2024 using the keywords misoprostol, prostaglandin E1 analogue, IUD, IUCD, intrauterine device, IUD insertion, and their MeSH terms.

Selection criteria
All RCTs that included misoprostol administration before IUD insertion. All doses, routes, and times of administration of misoprostol compared to placebo, analgesics, or other prostaglandins were included. This review included 19 RCTs including 2743 women (1333 had misoprostol administration and 1410 comparators (1281 received placebo, 16 received diclofenac, 43 received dinoglandin, and 70 received lignocaine).

Data collection and analysis
The extracted data included location setting, number of participants randomized and analyzed, participants selection criteria, the exact intervention details (including misoprostol dose, route and timing of administration, the comparator group details, and type of IUD inserted), primary and secondary outcomes of the trial ( including pain score, easiness of insertion score, the need for analgesics, the need for additional measures as cervical dilatation, failure of insertion, complications of the insertions process, and drug side effects), risk of bias of the included studies, and trial registration number and site.

Main results
Failure of IUD insertion was evaluated in 9 studies with 1350 participants and revealed an odd ratio (OR) of 0.87 with 0.39–1.98 95% CI, P value = 0.75, and I2 score = 45%.
The easiness score of insertion was evaluated in 7 studies with 780 participants and revealed an OR of − 1.12 with − 1.73 to 0.52 95% CI, P value < 0.001, and I2 score = 87%.
The pain VAS was evaluated in 13 studies with 1776 participants and revealed a mean difference (MD) of − 0.23 with − 0.77 to 0.31 95% CI, P value = 0.41, and I2 score = 90%.
The participants satisfaction score was evaluated in 3 studies with 366 participants and revealed a MD of 1.64 with 0.68–2.60 95% CI, P value < 0.001, and I2 score = 91%.
The need for analgesics and additional measures as cervical dilatation were evaluated in 7 and 4 studies with 813 and 295 participants respectively. The reported OR (95% CI), P values, and I2 scores were 0.58 (0.32–1.03) and 0.79 (0.33–1.92), 0.06 and 0.61, and 48% and 35% respectively.

Conclusion
Misoprostol administration before IUD insertion was associated with higher easiness score, higher women satisfaction score, and higher side effects named nausea, vomiting, cramps, shivering, headache, and fever compared to placebo administration.

Registration number
CRD42022364291.
The technological shift towards embedded payments: an examination of young consumers’ intention
Authors: Demir Ecenur , Özsoy Seren , Saygılı Metin 
Published: December 2024

AbstractThe surge in digital payment technologies and the swift transition to a cashless society have propelled the adoption of embedded payment systems, marking a significant shift in the payments landscape. Despite its increasing prevalence, the factors influencing the intention to use embedded payment systems remain underexplored in the academic literature. This study addresses this gap by analyzing the factors affecting young people’s intention to use embedded payment systems in Türkiye. Through a questionnaire survey of 807 respondents, the data was analyzed using Structural Equation Modeling. The findings reveal that lifestyle compatibility, social influence, personal innovativeness, hedonic motivation, and perceived trust collectively account for 72.6% of the variation in the intention to use embedded payment systems. However, the statistical insignificance of perceived ease of use and facilitating conditions suggests that other factors may significantly influence the intention to use these systems. This empirical study is the first of its kind on embedded payment systems, providing valuable insights into digital payments literature and guiding private sector professionals in devising effective strategies to promote widespread adoption of this payment method in Türkiye.
Evolution of Rapid Clonal Dynamics and Non–Cross-Resistance in Response to Alternating Targeted Therapy and Chemotherapy in BRAF-V600E-Mutant Colon Cancer
Authors: Simhadri Srilatha , Carrick Jillian N. , Murphy Susan , Kothari Om A. , Al-Hraishami Husam , Kulkarni Atul , Jalloul Nahed , Stefanik Katarina , Bandari Manisha , Chettur Kavya , Yao Ming , Ginjala Vasudeva , Groisberg Roman , Hochster Howard , Mehnert Janice , Riedlinger Gregory , Khiabanian Hossein , Verzi Michael P. , Tong Kevin , Ganesan Shridar 
Published: December 2024

PURPOSE
Combined BRAF, MEK, and EGFR inhibition can induce clinical responses in BRAF-V600E-mutant colon cancer, but rapid resistance often occurs.

METHODS
We use serial monitoring of circulating tumor DNA cell-free plasma DNA (cfDNA) in a patient case study in addition to organoids derived from mouse models of BRAF-V600E-mutant intestinal cancer, which emulated the patient's mutational profile to assess drug treatment efficacy.

RESULTS
We demonstrate dynamic evolution of resistance to combined EGFR/BRAF/MEK inhibition in a pediatric patient with metastatic BRAF-V600E-mutant, mismatch repair-stable colon cancer. Initial resistance to targeted therapy was associated with development of MET amplification. Sequential treatment with chemotherapy and targeted therapy resulted in clearing of the resistant MET-amplified clone. Rechallenge with combined BRAF/EGFR inhibition resulted in clinical and radiographic response, demonstrating these treatments may be non–cross-resistant. Tumor organoids were used to model clinical findings and demonstrated effectiveness of combined targeted therapy and chemotherapy.

CONCLUSION
These findings suggest rational strategies for combining sequential chemotherapy and BRAF-/EGFR-directed therapy in BRAF-V600E-mutant colon cancer to prevent resistance and improve outcome. The data demonstrate rapid clonal dynamics in response to effective therapies in BRAF-V600E-mutant colon cancer that can be monitored by serial cfDNA analysis. Moreover, in mismatch repair-proficient BRAF-V600E-mutant colon cancers, combined EGFR and BRAF/MEK therapy is not cross-resistant with standard chemotherapy, suggesting new rational combination treatment strategies.
The Longevity Benefits of Homeownership: Evidence From Early Twentieth-Century U.S. Male Birth Cohorts
Authors: Breen Casey F. 
Published: December 2024

Abstract
Owning a home has long been touted as a key component of the idealized “American Dream.” Homeownership is associated with greater wealth and better health, but the causal impact of homeownership on health remains unclear. Using linked complete-count census and Social Security mortality records, I document Black–White disparities in homeownership rates and produce the first U.S.-based estimates of the association between homeownership in early adulthood and longevity. I then use a sibling-based identification strategy to estimate the causal effect of homeownership on longevity for cohorts born in the first two decades of the twentieth century. The results indicate that homeownership has a significant positive impact on longevity, which I estimate at approximately 4 months.
Effect of cigarette smoke on the proliferation, viability, gene expression, and cellular functions of adipose-derived mesenchymal stem cells from smoking and non-smoking donors
Authors: Salah Bareqa , Shahin Diana , Sarhan Momen , Al-Karmi Joud , Al-Kurdi Ban , Al-Atoom Renata , Ismail Mohammad A. , Hammad Nouran , Jafar Hanan , Awidi Abdalla , Ababneh Nidaa A. 
Published: December 2024

ABSTRACT
Cigarette smoking negatively impacts mesenchymal stem cell functionality, including proliferation, viability, and differentiation potential. Adipose-derived mesenchymal stem cells (ADMSCs) are increasingly used for therapeutic purposes, but the specific effects of smoking in vivo on these cells are poorly understood. This study investigates the effects of cigarette smoke on the proliferation, viability, gene expression, and cellular functions of ADMSCs from smoking and non-smoking donors. In this study, ADMSCs were isolated from healthy smokers and non-smokers, and cell proliferation was assessed using the MTT assay, viability with apoptosis assays, mitochondrial membrane potential (MMP), and gene expression related to oxidative stress and cellular functions. Cell cycle analysis was also conducted. Our findings reveal a significant decrease in the proliferation of ADMSCs from smokers. Apoptosis assays showed reduced viable cells in smokers without a significant change in MMP, suggesting alternative pathways contributing to decreased viability. Gene expression analysis indicated the upregulation of genes associated with oxidative stress response and cellular defense mechanisms and the downregulation of genes related to inflammatory signaling, detoxification, and cellular metabolism. Cell cycle analysis indicates cycle arrest or delay in smokers, possibly due to stress and potential DNA damage. Smoking negatively affects ADMSCs’ proliferation, viability, and function through oxidative stress and gene expression alterations. These findings highlight the importance of considering smoking status in ADMSC therapies and the need for further research to mitigate the effect of smoking on stem cells.
Development and application of species ID and insecticide resistance assays, for monitoring sand fly Leishmania vectors in the Mediterranean basin and in the Middle East
Authors: Balaska Sofia , Khajehali Jahangir , Mavridis Konstantinos , Akiner Mustafa , Papapostolou Kyriaki Maria , Remadi Latifa , Kioulos Ilias , Miaoulis Michail , Fotakis Emmanouil Alexandros , Chaskopoulou Alexandra , Vontas John 
Published: December 2024

Background
Development of insecticide resistance (IR) in sand fly populations is an issue of public health concern, threatening leishmaniasis mitigation efforts by insecticide-based vector control. There is a major knowledge gap in the IR status of wild populations worldwide, possibly attributed to the unavailability of specialized tools, such as bioassay protocols, species baseline susceptibility to insecticides and molecular markers, to monitor such phenomena in sand flies.

Methodology/Principal findings
Sand fly populations from (semi-)rural regions of Greece, Turkey and Iran were sampled and identified to species, showing populations’ structure in accordance with previously reported data. Genotyping of known pyrethroid resistance-associated loci revealed the occurrence of voltage-gated sodium channel (vgsc) mutations in all surveyed countries. Knock-down resistance (kdr) mutation L1014F was prevalent in Turkish regions and L1014F and L1014S were recorded for the first time in Iran, and in Turkey and Greece, respectively, yet in low frequencies. Moreover, CDC bottle bioassays against pyrethroids in mixed species populations from Greece indicated full susceptibility, using though the mosquito discriminating doses. In parallel, we established a novel individual bioassay protocol and applied it comparatively among distinct Phlebotomus species’ populations, to detect any possible divergent species-specific response to insecticides. Indeed, a significantly different knock-down rate between P. simici and P. perfiliewi was observed upon exposure to deltamethrin.

Conclusions/Significance
IR in sand flies is increasingly reported in leishmaniasis endemic regions, highlighting the necessity to generate additional monitoring tools, that could be implemented in relevant eco-epidemiological settings, in the context of IR management. Our molecular and phenotypic data add to the IR map in an area with otherwise limited data coverage.
Methodological insights from the EPISTOP trial to designing clinical trials in rare diseases—A secondary analysis of a randomized clinical trial
Authors: Wied Stephanie , Hilgers Ralf-Dieter , Heussen Nicole , Kotulska Katarzyna , Dirani Maya , Kuchenbuch Mathieu , Jozwiak Sergiusz , Nabbout Rima 
Published: December 2024

Background
In clinical research, the most appropriate way to assess the effect of an intervention is to conduct a randomized controlled trial (RCT). In the field of rare diseases, conducting an RCT is challenging, resulting in a low rate of clinical trials, with a high frequency of early termination and unpublished trials. The aim of the EPISTOP trial was to compare outcomes in infants with tuberous sclerosis (TSC) who received vigabatrin preventively before the seizures onset with those who received it conventionally after. The study was designed as a prospective, multicentre, randomized clinical trial. However, ethics committees at four centres did not approve this RCT design, resulting in an open-label trial (OLT) in these four centres and an RCT in the other six centres. In this paper, we re-analyse the data from the EPISTOP trial using methods to investigate the influence of allocation bias on the results of the EPISTOP trial.

Method
A bias-corrected analysis is used to support and strengthen the published results. We included a term representing the effect of selection bias as an influencing factor on the corresponding endpoint in the statistical model. Thus, the treatment effect estimates for the primary endpoint of time to first seizure and additional secondary endpoints are adjusted for the bias effect.

Result
The bias-corrected analyses for the primary endpoint show that the estimated hazard ratio and associated confidence intervals are in a very similar range (original analysis: HR 2.91, 95%-CI [1.11 to 7.67], p-value 0.0306; bias-corrected analysis: HR 2.89, 95%-CI [1.10 to 7.58], p-value 0.0316). This was also the case for the secondary endpoints.

Conclusion
The statistical re-analysis of the raw trial data therefore supports the published results and confirms that there is no additional bias introduced by randomization, thereby increasing the value of the results. However, this highlights that this aspect needs to be considered in future trials, especially in rare diseases, to avoid additional biases in an already small sample size where it may be difficult to reach significance.
Improving access to specialist care in correctional facilities through Ontario eConsult
Authors: Goulet Danica , Sethuram Claire , Keely Erin , Liddy Clare 
Published: December 2024

Objectives
To evaluate the accessibility of multispecialty advice for primary care providers (PCPs) within correctional facilities, catering to the healthcare needs of individuals in federal custody in Ontario, Canada, through the utilization of electronic consultation (eConsult).

Design
Retrospective, cross-sectional, descriptive analysis.

Setting
eConsults submitted by PCPs within federal correctional facilities through the Ontario eConsult Service between April 1st, 2019, and March 31st, 2023.

Participants
906 completed eConsults were submitted by 21 PCPs in correctional facilities.

Results
The top three specialties sent to were cardiology (46%, N = 417), dermatology (14%, N = 128), and endocrinology and metabolism (8%, N = 68). The median specialist response time was 0.9 days. The median time specialists spent responding to each case was 15 minutes. PCPs received advice on a new or additional course of action in 34% of eConsult cases. In-person specialist appointments were avoided in 81% of cases.

Conclusions
Ontario eConsult provides an ideal venue to improve access to multispecialty advice for people who are incarcerated. This service reduces the need for face-to-face specialist visits, decreases cost-of-care, and avoids unnecessary transportation outside of correctional facilities with potential security issues.
Umgang mit dem Unsichtbaren – Neurodiversity-Management in Bibliotheken
Authors: Stecker Sandra , Albers Miriam 
Published: December 2024

Zusammenfassung
Während die Zahlen der Autismus- und ADHS-Diagnosen konstant steigen, gibt es momentan noch keine erkennbaren, inklusiven Maßnahmen zur Förderung neurodivergenten Bibliothekspersonals. Gründe dafür sind u. a., dass Neurodivergenz unsichtbar ist, oft nicht oder erst spät erkannt wird und in beruflichen Kontexten meistens maskiert wird. Zudem fehlt bei unsichtbaren Behinderungen häufig noch das Bewusstsein darüber, dass diese in der Regel unterstützt werden können bzw. müssen, sowie eine Vorstellung darüber, wie genau Unterstützungsangebote aussehen könnten.
Das Ziel dieses, auf einer Bachelorarbeit basierenden, Artikels ist es, über diesen Unterstützungsbedarf aufzuklären und Vorschläge möglicher Unterstützungsangebote zu formulieren. Dabei stehen die neurodivergenten Konditionen Autismus, ADHS, Dyskalkulie und Legasthenie im Fokus. Der Auskunftsdienst wird zusätzlich als Beispiel für einen herausfordernden bibliothekarischen Bereich thematisiert.
Modification of the 5D Lorenz chaotic map with fuzzy numbers for video encryption in cloud computing
Authors: Alrubaie Asmaa Hasan , Khodher Maisa’ A. Abid Ali , Abdulameer Ahmed Talib 
Published: December 2024

Abstract
As surveillance cameras have proliferated in usage, their widespread deployment has raised privacy concerns. We introduce an inventive strategy to safeguard privacy in surveillance videos to address these concerns. This article designs a secure system for detecting and encrypting regions of interest (ROIs) that depict multiple individuals within video footage. The suggested system is composed of three phases, with the initial phase incorporating an object detection model to efficiently detect individuals in video frames with the You Only Look Once version 7 architecture. The second stage encrypts ROIs with our unique algorithm, which represents a novel technique derived from combining triple DNA with the modification of the 5D Lorenz chaotic map using fuzzy triangular numbers, which are utilized in key generation. The reverse of this process is a decryption that obtains the original video. The third stage combines all encrypted ROIs from the reconstructed video frames to be securely stored as encrypted video in the cloud. Evaluation results show that the utmost value of the unified averaged changed intensity and the number of changing pixel rate stand at 33.8000 and 99.8934%, respectively, with encryption and decryption speeds up to 7.06 and 6.72 s, respectively.
Writing to be read, or how to achieve more through less [Language Matters]
Authors: Carney Terrence R 
Published: December 2024

Abstract
Wolfgang Klein’s observation in 1989 that a steady rise in academic publications affects a scientist’s capacity to read and write more extends to issues like funding, tenure, and citation on the one hand, and technological advancements like artificial intelligence that enable (and corrupt) research on the other. In documenting speakers’ linguistic behaviour in varied social settings, sociolinguistics journals are necessary platforms for the dissemination and archiving of sociolinguistic data. Like many academic journals, however, sociolinguistics journals also play a vital role in amassing information, simultaneously contributing to sociolinguistic progress and data excess. In this commentary, I agree with Klein that production should be reduced to some extent for authors to both read and write, and to contribute content in support of the research – not simply to be published.
Acceleration, capitalist temporalities and collective challenges in academic publishing [Language Policy]
Authors: Pérez-Milans Miguel , Menken Kate 
Published: December 2024

Abstract
This article engages with Wolfgang Klein’s (1989. Schreiben oder Lesen, aber nicht beides, oder: Vorschlag zur Wiedereinführung der Keilschrift mittels Hammer und Meißel. Zeitschrift für Literaturwissenschaft und Linguistik) invitation in Schreiben oder Lesen, aber nicht beides, oder: Vorschlag zur Wiedereinführung der Keilschrift mittels Hammer und Meißel to think about the emergence of the knowledge industry and the extent to which it makes it impossible for readers of scientific journals to keep up with overproduction. Taking acceleration as a key economic property that governs contemporary academic capitalism, we explore some inner workings of this industry but also examples of collective (and prefigurative) initiatives that have attempted to undermine such workings in non-academic settings, in order to reflect more specifically on the possible implications for academic publishing. In so doing, we identify some relevant features as to how capitalist temporalities organise scientific editorial work, and provide a few focal points of consideration with the hope of contributing to wider conversations on how to begin (re)imagining alternative ways of doing academic publishing.