bluuebunny/crossref_metadata_2025_split huggingface dataset:
A sulfonimide derivative of bezafibrate as a dual inhibitor of cyclooxygenase-2 and PPARα
Authors: Ammazzalorso Alessandra , Tacconelli Stefania , Contursi Annalisa , Hofling Ulrika , Cerchia Carmen , Di Berardino Sara , De Michele Alessandra , Amoroso Rosa , Lavecchia Antonio , Patrignani Paola 
Published: November 2024

BackgroundPPARα and cyclooxygenase (COX)-2 are overexpressed in certain types of cancer. Thus, developing a dual inhibitor that targets both could be more effective as an anticancer agent than single inhibitors. We have previously shown that an analog of the bezafibrate named AA520 is a PPARα antagonist. Herein, we report the identification of AA520 as a potent COX-2 inhibitor using in silico approaches. In addition, we performed a thorough pharmacological characterization of AA520 towards COX-1 and COX-2 in different in vitro models.MethodsAA520 was characterized for inhibiting platelet COX-1 and monocyte COX-2 activity in human whole blood (HWB) and for effects on lipidomics of eicosanoids using LC-MS/MS. The kinetics of the interaction of AA520 with COX-2 was assessed in the human colon cancer cell line, HCA-7, expressing only COX-2, by testing the COX-2 activity after extensive washing of the cells. The impact of AA520 on cancer cell viability, metabolic activity, and cytotoxicity was tested using the MTT reagent.ResultsIn HWB, AA520 inhibited in a concentration-dependent fashion LPS-stimulated leukocyte prostaglandin (PG) E2 generation with an IC50 of 0.10 (95% CI: 0.05–0.263) μM while platelet COX-1 was not affected up to 300 μM. AA520 did not affect LPS-induced monocyte COX-2 expression, and other eicosanoids generated by enzymatic and nonenzymatic pathways. AA520 inhibited COX-2-dependent PGE2 generation in the colon cancer cell line HCA7. Comparison of the inhibition of COX-2 and its reversibility by AA520, indomethacin (a time-dependent inhibitor), acetylsalicylic acid (ASA) (an irreversible inhibitor), and ibuprofen (a reversible inhibitor) showed that the compound is acting by forming a tightly bound COX-2 interaction. This was confirmed by docking and molecular dynamics studies. Moreover, AA520 (1 μM) significantly reduced MTT in HCA7 cells.ConclusionWe have identified a highly selective COX-2 inhibitor with a unique scaffold. This inhibitor retains PPARα antagonism at the same concentration range. It has the potential to be effective in treating certain types of cancer, such as hepatocellular carcinoma (HCC) and renal cell carcinoma (RCC), where COX-2 and PPARα are overexpressed.
Longitudinal predictors for internalizing and externalizing symptomatology at age 4: KUNO-Kids cohort study
Authors: Jarvers Irina , Kandsperger Stephanie , Ecker Angelika , Brandstetter Susanne , Kabesch Michael , Köninger Angela , Melter Michael , Kerzel Sebastian , Kittel Jochen , Apfelbacher Christian , Brunner Romuald 
Published: November 2024

IntroductionNumerous early-life risk factors are thought to significantly contribute to the development of psychological problems in toddlerhood. However, these factors have seldom been investigated concomitantly and longitudinally, and few studies include both mothers and fathers. This study examines the longitudinal impact of early environmental, parental, and child-specific risk factors on children’s internalizing and externalizing symptomatology at age 4.MethodsFamilies were recruited from a perinatal center at birth and completed self-report questionnaires at birth, 4 weeks postpartum, 6 months postpartum, and annually thereafter. The final population-based sample consisted of n = 560 mothers (and fathers) who gave birth after June 2015, with children who turned 4 years old before March 31, 2021. The primary outcomes, children’s internalizing and externalizing symptomatology at age 4, were measured using the Strengthsand Difficulties Questionnaire. Linear mixed effect models were used to estimate growth curves for predictors between 4 weeks and 4 years postpartum, which were subsequently entered into multivariable linear regressions to predict internalizing and externalizing symptomatology at age 4.ResultsThe study identified several key risk factors: environmental (lack of social support, lower parental education, male sex), parental (poor parental mental health, increased parenting stress, parental sleep difficulties) and child-specific (children’s low physical health, children’s reduced sleep quality, temperament).DiscussionThe findings underscore that most identified risk factors are related to children’s temperament, mental and physical health of parents, their experienced stress, and families’ social support networks. These insights highlight the importance of targeted interventions focusing on improving parental mental health, reducing stress, and enhancing social support to mitigate early-life psychological problems in children.
Characteristics of hypertension and its impact on cognitive functions in older adults: a cross-sectional study
Authors: Parandiyal Nivedita , Chutia Porimita , Sinha Shashank Saurabh , Pandit Pratyaksha , Majrashi Naif Ali , Qureshi Naseem , Tripathi Shailendra Mohan 
Published: November 2024

BackgroundHypertension is a potentially modifiable risk factor for cognitive decline. Understanding the variables of hypertension related to cognitive functions will help in mitigating the risk.ObjectiveThe study aims to assess the characteristics of hypertension and its effect on cognitive functions in the older adults.MethodsThe study involved 95 hypertensive participants aged 60 years and above from cardiology and medicine outpatient services of a tertiary care hospital from August to October 2022. The characteristics of hypertension and cognitive functions were assessed using semi-structured proforma and Adenbrooke's Cognitive Examination (ACE-III) Hindi version respectively. Further, individual cognitive functions were compared with duration of the hypertension and hypertensive status of the participants. The chi-square test and independent t-tests were used and p value &lt; 0.05 was considered to be significant.ResultThe mean age of the study population was 68.2 years, the cognitive functions was comparable in terms of age, sex, locality, co-morbidity, and treatment characteristic. Although a significant difference in cognitive functions was present in relation to duration and status of hypertension. Among the individual cognitive domains, a significant difference was observed in attention and fluency domains of cognitive function based on HTN status (p &gt; 0.05) but differential effect on cognitive domains was not seen with the duration of HTN. However, there was overall decline in cognitive domains with both hypertension status and the duration of hypertension.ConclusionThe study highlights association of status of hypertension and its characteristics with cognitive decline.
Case Report: Abdominal Wall Abscess as First Clinical Sign of Jejunal Perforation After Blunt Abdominal Trauma
Authors: Martínez-López M. , Verdaguer-Tremolosa M. , Rodrigues-Gonçalves V. , Martínez-López M. P. , López-Cano M. 
Published: November 2024

AimTo discuss extended retrorectal abscess secondary to blunt abdominal trauma as a cause of abdominal wall (AW) infection and impairment.MethodsAccording to the CARE checklist, we describe a rare case of blunt abdominal trauma with late diagnosis of jejunal perforation with an abscess that extensively dissected the retromuscular space.ResultsA 65 years-old female patient experienced multiple traumas after a traffic collision. Ten days after admission, the patient presented with swelling in the right abdomen. CT scan showed localised pneumoperitoneum and extensive collection affecting the right retrorectal space, reaching the ribs and preperitoneal space. Urgent laparotomy was performed and jejunal perforation with biliary peritonitis and extraperitoneal extension with dissection of the right retrorectal space were found. Intestinal resection with anastomosis was then performed. Exhaustive lavage of the cavity and retromuscular space with debridement of the necrotic posterior rectus lamina was required. Retrorectal drainage was placed. Primary closure of the aponeurosis was achieved using a small-bites technique with a slowly absorbable monofilament suture. Due to the weakness of the abdominal wall, an absorbable biosynthetic mesh impregnated with gentamicin was placed onlay. Negative pressure therapy was applied to the closed wound. Patient received antibiotics and CTs showed favourable evolution. No infectious complications or incisional hernia were reported after 12 months of follow-up.ConclusionNo cases of blunt trauma causing extensive AW infection have been reported in the literature. Whilst rare, this should be considered in traumatic patients. Our experience shows that they can be managed with surgical drainage and absorbable meshes can be considered in cases of fascial loss.
Pengaruh Model Problem Based Learning terhadap Kemampuan Generik Sains dan Pemahaman Konsep Siswa
Authors: Hambarwati Sri , Muhali Muhali , Taloin Rensani 
Published: November 2024

Penelitian ini bertujuan untuk mengkaji pengaruh model Problem-Based Learning (PBL) terhadap kemampuan generik sains dan pemahaman konsep siswa pada materi reaksi reduksi-oksidasi. Metode kuasi-eksperimen dengan desain pretest-posttest control group digunakan pada 53 siswa kelas X di SMA Islam Al-Azhar NW Kayangan, yang dibagi secara acak menjadi kelompok eksperimen (n=25) dan kontrol (n=28). Hasil penelitian menunjukkan bahwa kelompok eksperimen yang diajarkan dengan PBL mengalami peningkatan signifikan dalam kemampuan generik sains, terutama pada indikator bahasa simbolik (nilai rata-rata posttest 75,00) dan inferensi logika (29,00), dengan signifikansi 0,000. Peningkatan pemahaman konsep siswa juga signifikan pada kelompok eksperimen, dengan rata-rata posttest 70,60 dibandingkan kelompok kontrol yang hanya mencapai 46,00 (signifikansi 0,003). Temuan ini menunjukkan bahwa PBL lebih efektif daripada metode konvensional dalam meningkatkan kemampuan generik sains dan pemahaman konsep siswa dalam materi kimia yang kompleks. Penerapan PBL dalam pembelajaran kimia di sekolah disarankan untuk meningkatkan kualitas pemahaman siswa terhadap konsep-konsep abstrak.
The Effect of Problem-Based Learning Model on Students’ Generic Science Skills and Conceptual Understanding
Abstract
This study aimed to examine the effect of the Problem-Based Learning (PBL) model on students' generic science skills and conceptual understanding of redox reactions. A quasi-experimental method with a pretest-posttest control group design was employed with 53 tenth-grade students from SMA Islam Al-Azhar NW Kayangan, who were randomly assigned into an experimental group (n=25) and a control group (n=28). The findings revealed that the experimental group taught using PBL showed a significant increase in generic science skills, particularly in symbolic language (posttest mean score of 75.00) and logical inference (29.00), with a significance level of 0.000. Conceptual understanding also improved significantly in the experimental group, with a posttest mean score of 70.60, compared to 46.00 in the control group (significance level of 0.003). These results indicate that PBL is more effective than conventional methods in enhancing both generic science skills and conceptual understanding in complex chemistry topics. The study recommends PBL application in chemistry education to deepen students' understanding of abstract concepts.
La série des températures journalières à Paris de 1658 à 2023
Authors: Rousseau Daniel 
Published: November 2024

Depuis 1658, la température est mesurée presque continuellement à Paris. Les enregistrements de ces mesures apparaissent dans des manuscrits, des publications ou des bases de données. Afin de mettre à disposition ce patrimoine unique, ils ont été collectés et numérisés pour constituer une série de températures journalières en degrés Celsius. Les sources de ces données, les conditions de mesure ainsi que les modalités de calcul de la température journalière sont explicitées dans cet article, dont une annexe numérique (en ligne) fournit les moyennes journalières et les moyennes mensuelles des températures à Paris de 1658 à 2023.
Since 1658 the temperature has been measured in Paris almost continuously. The records of these measurements appear in manuscripts, publications or databases. In order to make this unique heritage available, they have been collected and digitized to constitute a series of daily temperatures in degrees Celsius. The sources of these data, the measurement conditions as well as the methods for computing the daily temperature are explained in this article to which is joined an annex providing the daily and monthly averages of temperatures in Paris from 1658 to 2023.
MANAGEMENT STRATEGY OF ACID MINE WATER POTENTIAL AT PT PASIR WALANNAE BONE DISTRICT SOUTH SULAWESI
Authors: Fahrullah Muh , Kandora Tri Andriyani HS , Ervina Ervina 
Published: November 2024

Hubungan antara kegiatan penambangan dengan lingkungan selalu menjadi isu hangat hingga saat ini. Salah satu bagian yang menjadi perhatian adalah adanya pencemaran air yang disebabkan oleh kegiatan penambangan. Lokasi penelitian yaitu PT Pasir Walannae yang merupakan perusahaan tambang batubara saat ini tidak beroperasi dan menghasilkan bekas penambangan yang belum dilakukan treatment dan terdapat adanya air asam tambang hasil dari galian penambangan. Berdasarkan hal tersebut maka penelitian ini dilakukan dengan tujuan penelitian menganalisis karakteristik dari air asam tambang dan penanganan yang tepat dalam mengurangi dampak di daerah penelitian PT Pasir Walannae Lamuru Kabupaten Bone Provinsi Sulawesi Selatan. Sampel yang digunakan dalam penelitian ini yaitu sampel air asam tambang dianalisis menggunakan metode analisis sifat fisika (pH, ORP, TDS, dan kekeruhan) dan sifat kimia terdiri dari kadar unsur (SO4, Fe, Mn, Cd). Hasil yang diperoleh yaitu nilai pH 3,1 tidak mencapai batas baku mutu lingkungan, ORP 717 mV, TDS 2077 mg/l dan kekeruhan berdasarkan tabel NTU sebesar 250 melebihi batas baku mutu lingungan. Berdasarkan analisis sifat kimia unsur-unsur tersebut juga melebihi batas baku mutu lingkungan, yaitu pada unsur SO4 sebesar 71,63, unsur Fe 9,46, unsur Mn 1,01, terkecuali unsur Cd sebesar <0,01 dan masih dalam kategori tidak melebihi batas baku mutu. Pencegahan air asam tambang dilokasi penelitian dapat dilakukan dengan metode PAF dan NAF yaitu metode penimbunan material berpotensi membentuk air asam tambang dgn material yang tidak berpotensi air asam tambang. Kesimpulan dari penelitian ini yaitu berdasarkan sifat fisika dan sifat kimia air asam tambang dilokasi penelitian telah melebihi batas baku mutu lingkungan berdasarkan acuan Baku Mutu Lingkungan Peraturan Menteri Kesehatan Republik Indonesia Nomor 2 Tahun 2023 Tentang Kesehatan Lingkungan air pada lubang bekas penambangan batubara dikategorikan sebagai air yang tercemar atau sebagai air asam tambang
Beneficios y contradicciones de las evaluaciones de base estructurada en el proceso de enseñanza-aprendizaje
Authors: Vivanco Mocha Juliana Estefania , Guerra Ramirez Neli Marleni , Carriel López Darío Fabián , Cunalata Ati Viviana Lucia , Vera Reyes Rosanna Jenniffer 
Published: November 2024

En el presente artículo se analizó bibliográficamente los beneficios y contradicciones de las evaluaciones de base estructurada en relación al proceso de enseñanza aprendizaje, enfocados en la educación en niños mayores de 13 años. Para ello, se llevó a cabo la revisión sistemática de base de datos como Google académico, Ciencias de la información de recursos educativos (ERIC), Polo del conocimiento, Dialnet, Scielo, Redalyc y repositorios universitarios de Ecuador, publicadas en un periodo de los últimos 10 años. Entre los hallazgos, muestra que la mayoría de los docentes adoptan la prueba de base estructurada para medir desempeño académico, lo que resulta satisfactorio para verificar la asimilación conceptual de los contenidos impartidos en clases, sin embargo, limita el proceso de enseñanza aprendizaje al no ofrecer retroalimentación de los estudiantes hacia los docentes, quedando de lado el desenvolvimiento de destrezas surgidas del proceso, algunos autores proponen el uso de software para fortalecer metacognitivamente los reactivos en este modelo de prueba pedagógica. En conclusión, la adaptabilidad de las evaluaciones de base estructurada a los contenidos, competencias y actividades curriculares de la malla escolar, resulta beneficia como parte del proceso de enseñanza aprendizaje, sin embargo, se recomienda fortalecerse con herramientas de la tecnología de la información para contrarrestar los efectos de la poca interacción docente-estudiante.
Condiciones de Habitabilidad en la Expansión Urbana Informal en el AA.HH. Nadine Heredia, Banda de Shilcayo
Authors: Padilla García Milenka Danuzka , Gonzáles Cumapa Betsabe , Alegría Lazo Katty Marilyn 
Published: November 2024

Esta investigación se centró en analizar la calidad de vida en el asentamiento negligente de Nadine Heredia, ubicado en la Banda de Shilcayo. Dicha zona se ha expandido rápidamente sin una planificación adecuada, lo cual planteó importantes desafíos en términos de infraestructura, servicios básicos y bienestar de vida de sus pobladores. El objetivo de estudio fue describir las condiciones de habitabilidad en este asentamiento, evaluando aspectos como vivienda, acceso a servicios básicos, salud, educación y seguridad. Además, se buscó comprender el impacto de este crecimiento urbano informal en el bienestar de vida de los residentes, considerando sus propias percepciones sobre su entorno y condiciones de vida. A partir de los hallazgos, se investigaron situaciones similares y se analizaron sus recomendaciones para restablecer la situación de vida y alojamiento en áreas similares. De esta manera, el proyecto buscó aportar a la mejora de la habitabilidad en el asentamiento humano Nadine Heredia. Brindando una base firme para tomar decisiones conscientes y la planificación de ciudades. Esta información permite a los encargados de toma de decisiones y a los profesionales urbanos contar con datos sólidos, lo que les ayuda a desarrollar estrategias y planes más eficaces y adaptados a las necesidades de la comunidad.
Ages of Stars and Planets in the Kepler Field Younger than Four Billion Years
Authors: Bouma Luke G. , Hillenbrand Lynne A. , Howard Andrew W. , Isaacson Howard , Masuda Kento , Palumbo Elsa K. 
Published: November 2024

Abstract
Recent analyses of FGK stars in open clusters have helped clarify the precision with which a star’s rotation rate and lithium content can be used as empirical indicators for its age. Here we apply this knowledge to stars observed by Kepler. Rotation periods are drawn from previous work; lithium is measured from new and archival Keck/HIRES spectra. We report rotation-based ages for 23,813 stars (harboring 795 known planets) for which our method is applicable. We find that our rotational ages recover the ages of stars in open clusters spanning 0.04–2.5 Gyr; they also agree with ≳90% of the independent lithium ages. The resulting yield includes 63 planets younger than 1 Gyr at 2σ, and 109 with median ages below 1 Gyr. This is about half the number expected under the classic assumption of a uniform star formation history. The age distribution that we observe, rather than being uniform, shows that the youngest stars in the Kepler field are 3–5 times rarer than stars 3 Gyr old. This trend holds for both known planet hosts and for the parent stellar sample. We attribute this “demographic cliff” to a combination of kinematic heating and a declining star formation rate in the Galaxy’s thin disk, and highlight its impact on the age distribution of known transiting exoplanets.
WTP 19aalnxx: Discovery of a Bright Mid-infrared Transient in the Emerging Class of Low-luminosity Supernovae Revealed by Delayed Circumstellar Interaction
Authors: Myers Charlotte , De Kishalay , Yan Lin , Jencson Jacob E. , Earley Nicholas , Fremling Christoffer , Hiramatsu Daichi , Kasliwal Mansi M. , Lau Ryan M. , MacLeod Morgan , Masterson Megan , Panagiotou Christos , Simcoe Robert , Tinyanont Samaporn 
Published: November 2024

Abstract
While core-collapse supernovae (SNe) often show early and consistent signs of circumstellar medium (CSM) interaction, some exhibit delayed signatures due to interaction with distant material around the progenitor star. Here we present the discovery in NEOWISE data of WTP 19aalnxx, a luminous mid-infrared (MIR) transient in the outskirts of the galaxy KUG 0022-007 at ≈190 Mpc. First detected in 2018, WTP 19aalnxx reaches a peak absolute (Vega) magnitude of ≈−22 at 4.6 μm in ≈3 yr, comparable to the most luminous interacting SNe. Archival data reveal a ≳5× fainter optical counterpart detected since 2015, while follow-up near-infrared observations in 2022 reveal an extremely red (Ks − W2 ≈ 3.7 mag) active transient. Deep optical spectroscopy confirm strong CSM interaction signatures via intermediate-width Balmer emission lines and coronal metal lines. Modeling the broadband spectral energy distribution, we estimate the presence of ≳10−2
M
⊙ of warm dust, likely formed in the cold dense shell. Together with the lack of nebular Fe emission, we suggest that WTP 19aalnxx is a missed, low (optical) luminosity SN in an emerging family of core-collapse SNe distinguished by their CSM-interaction-powered MIR emission that outshines the optical bands. Investigating the Zwicky Transient Facility sample of SNe with NEOWISE data, we find 16 core-collapse SNe (≳3% in a volume-limited sample) without early signs of CSM interaction that exhibit delayed IR brightening, suggestive of dense CSM shells at ≲1017 cm. We suggest that synoptic IR surveys offer a new route to revealing late-time CSM interaction and the prevalence of intense terminal mass loss in massive stars.
X-Ray Spectra of Black Hole X-Ray Binaries with Returning Radiation
Authors: Mirzaev Temurbek , Bambi Cosimo , Abdikamalov Askar B. , Jiang Jiachen , Liu Honghui , Riaz Shafqat , Shashank Swarnim 
Published: November 2024

Abstract
In the disk–corona model, the X-ray spectrum of a stellar-mass black hole in an X-ray binary is characterized by three components: a thermal component from a thin and cold accretion disk, a Comptonized component from a hot corona, and a reflection component produced by illumination of the cold disk by the hot corona. In this paper, we assume a lamppost corona, and we improve previous calculations of the X-ray spectrum of black hole X-ray binaries. The reflection spectrum is produced by the direct radiation from the corona as well as by the returning radiation of the thermal and reflection components and is calculated considering the actual spectrum illuminating the disk. If we turn the corona off, the reflection spectrum is completely generated by the returning radiation of the thermal component, as it may happen for some sources in soft spectral states. After choosing the radial density profile of the accretion disk, the ionization parameter is calculated self-consistently at any radial coordinate of the disk from the illuminating X-ray flux and the local electron density. We show the predictions of our model in different regimes, and we discuss its current limitations as well as the next steps to improve it.