bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Gout Care in a Canadian Academic Medical Center Through a Multidisciplinary Nurse-Led Protocol
Authors: Audet Thomas , Picard-Turcot Marie-Aude , Robindaine Julie , Carrier Nathalie , Dagenais Pierre 
Published: December 2024

ObjectiveFollowing Health Canada's knowledge translation framework, we report the results of a clinical audit from 2012 to 2015 followed by a multidisciplinary, nurse-led gout care protocol with a treat-to-target (T2T) strategy implemented in April 2018.MethodsA clinical audit with chart reviewing was completed for adults with gout and urate-lowering therapy (ULT) indication at the Centre Hospitalier Universitaire de Sherbrooke. A nurse-led treatment algorithm using allopurinol was then developed. Titration of ULT by a nurse every 4 weeks was done until serum uric acid (SUA) target. In the postprotocol implementation, adults with gout and ULT indication were retrospectively recruited through a billing agency until December 2020. The main outcome was SUA target achievement at 6 months.ResultsOf 50 patients identified in the audit, 31% reached SUA target at 6 months and 16% were lost to follow-up. A 74-patient postprotocol implementation cohort was recruited, with 43 in the protocol group and 31 under usual care. Most prevalent ULT indication was ≥ 2 gout attacks per year (n = 52) at 70%. Target SUA was reached in 65% (n = 28) in the protocol group at 6 months compared to 19% (n = 6) in the usual care group (P< 0.001). Failing to titrate medication in the usual care group was the leading cause for nonachievement of SUA target at 6 months. Five percent of patients were lost to follow-up, all in the usual care group.ConclusionA multidisciplinary, nurse-led protocol with a T2T strategy implemented after a clinical audit significantly improved gout care. Such protocol could be replicated elsewhere in Canada.
Religions et conflits dans les relations internationales
Authors: Maila Joseph 
Published: December 2024

Dans le passé, la religion a joué un rôle significatif dans les relations internationales. On pourrait penser que la sécularisation actuelle la fait passer à l’arrière-plan. Ce n’est pas si simple. Il faut convenir que les « retours » du religieux sont plutôt conflictuels. Pourtant, des instances religieuses œuvrent au profit de la paix.
Naftali Bennett et le sionisme religieux
Authors: Cohen Samy 
Published: December 2024

À sa fondation, l’État d’Israël s’est voulu laïque. Mais les partis religieux exercent une influence de plus en plus sensible. C’est le cas en particulier du « sionisme religieux ». Il importe de connaître l’histoire de ce courant adepte du « Grand Israël », qui éprouva les pires dérives. Comment un groupe naguère marginal a-t-il réussi à apparaître comme héritier des fondateurs d’un État laïque ? Son ascension paraît durable, même si la coalition gouvernementale présidée par Naftali Bennett n’aura pas tenu longtemps.
Enquêter en terrain cosmopolite au Sénégal
Authors: Lessault David , Bigot Brenda Le , Niang Marème , Fleuret Sébastien , Samb Mohamadou , Cira Caroline , Sakho Papa , Sarr Ndeye Fatou , Pinel Jordan 
Published: December 2024

Dans cet article nous nous interrogeons, à partir d’une expérience de terrain partagée au Sénégal en octobre 2022, sur les implications méthodologiques du caractère collectif et international d’une recherche en géographie. Le projet CIRCUS est mené en collaboration entre l’université d’Angers en France et l’Université Cheikh Anta Diop de Dakar au Sénégal. La mixité de l’équipe a été pensée en amont du projet comme une condition visant à dépasser certaines limites d’accès à des lieux a priori fermés et à des populations méfiantes dans un contexte local de relations sociales ambigües et asymétriques. Dans un espace touristique d’un pays du Sud en pleine mutation comme la ville de Saly, le·la chercheur·e peut rapidement être dérouté.e par la complexité des rapports à l’espace, l’hybridation et/ou le cloisonnement des pratiques d’une population devenue cosmopolite et poursuivant des intérêts souvent divergents. L’enquête et les observations par binômes franco-sénégalais visait une meilleure couverture sociale et spatiale du terrain. Finalement, cette recherche d’efficacité dans le recueil des matériaux et des informations aboutit à interroger la posture du·de la chercheur·e sur le terrain et à redessiner, sous l’effet d’un regard pluriel, les contours de la problématique initiale du projet.
Produire l’universalité savante depuis l’arène locale : les cartographies végétales de l’Historia generalis plantarum (Lyon, 1586)
Authors: Goldman Oury 
Published: December 2024

En 1586, l’Historia generalis plantarum paraît à Lyon chez le libraire Guillaume Rouillé. Cet ouvrage monumental (2 034 pages et 2 686 gravures) a pour ambition de proposer un tableau « général » et « universel » des savoirs botaniques de son temps, notamment par l’intégration tant de plantes exotiques que d’espèces poussant à Lyon et dans ses environs. Cet article s’attache à montrer combien cette prétention à l’universalité s’est nourrie de l’inscription locale du projet dans la configuration singulière de la cité de Lyon au xvie siècle. L’ouvrage est le fruit d’opérations qui ont pour centre une ville, certes dynamique à l’échelle du royaume de France et de l’Europe, à la fois frontière et carrefour, mais également affectée par les conséquences des guerres de Religion. Ainsi, l’ouvrage résulte d’interactions sociales et savantes mettant en jeu des relations de voisinage entre médecins, apothicaires, libraires et graveurs, inscrites dans certains lieux clés comme la boutique du libraire ou les jardins de la ville.
Une histoire « au ras du fleuve » ? Approche multiscalaire des trafics clandestins au bord du Rhône entre Lyon et la Méditerranée (fin xviie-xviiie siècle)
Authors: Bournat-Quérat Cécile 
Published: December 2024

Reliant l’Europe du Nord au monde méditerranéen, le Rhône est un axe commercial fréquenté sur lequel transitent des produits venus du monde entier, notamment via le port franc de Marseille. Il dessine également une frontière mouvante et contestée qui, séparant des provinces aux différents régimes fiscaux, favorise les tentatives de fraude et de contrebande. Pour appréhender ces phénomènes, il est nécessaire de multiplier les points d’observation sur le fleuve. L’approche multiscalaire met en relief des situations différenciées générant plusieurs formes de trafics clandestins et dévoile certaines spécificités du Rhône. Outre la variation des échelles spatiales, il faut prendre en considération les évolutions chronologiques pour une étude qui couvre la fin du xviie siècle et le xviiie siècle. Ce travail repose donc sur une démarche empirique et l’analyse de cas. Il s’inspire de l’expérimentation micro-historique et se nourrit des apports des autres sciences humaines et sociales.
Pour en finir avec le Grand Tour : les échelles du voyage dans l’Europe des Lumières
Authors: Montègre Gilles 
Published: December 2024

Le concept de « Grand Tour » a colonisé depuis 30 ans les études sur le voyage dans l’Europe moderne, alors même que le terme n’était pas utilisé par les voyageurs d’Ancien Régime. Cette appropriation terminologique a eu pour effet d’appauvrir la compréhension du voyage comme pratique d’émancipation pour des couches sociales non privilégiées, en particulier à l’époque des Lumières. La préférence donnée aux archives de voyage plutôt qu’aux récits publiés permet de faire varier les échelles d’analyse géographique et sociologique, et par conséquent de transformer radicalement la compréhension de l’expérience voyageuse. C’est ce qui ressort ici de l’approche quantitative et cartographique des nombreuses archives de voyage laissées par le savant bordelais François-de-Paule Latapie durant la décennie 1770. La variation des échelles d’observation met ainsi en évidence la réalité autonome d’un « voyage des Lumières », qui ne peut être assimilé ni au prolongement du Grand Tour aristocratique, ni à la préfiguration du tourisme.
Outiller la pensée du devenir incertain des matériaux
Authors: Durand Emmanuelle 
Published: December 2024

Envisageant les matériaux depuis leurs signes de précarité, leurs manifestations d’usure et leur devenir incertain, ce texte interroge les manières d’outiller une pensée scientifique attachée à documenter de façon analytique et critique la place et le rôle de la part matérielle dans, et sur, la fabrique du social. À partir de la mise en regard et de la discussion de contributions portant sur des infrastructures numériques pour l’une (câble sous-marin de télécommunication) et scénographique pour l’autre (tapis de LED) parues en 2023 dans la Revue d’anthropologie des connaissances, ce texte s’emploie à rendre compte de ce que l’attention analytique portée aux « fragilités matérielles » rend perceptible et saillant.
Adolphe Blanqui, 1798-1854
Authors: Démier Francis 
Published: December 2024

« L’égalité n’est pas un vain mot. » L’idée revient souvent chez Adolphe Blanqui, économiste libéral et portrait inversé de son frère Auguste, le Révolutionnaire, l’Enfermé. Elle pourrait sembler singulière chez ce notable libre-échangiste de la monarchie orléaniste, disciple de Jean-Baptiste Say, professeur d’économie politique, directeur de l’École de commerce de Paris, membre de l’Institut, député orléaniste d’une Gironde conservatrice.Rien de paradoxal pourtant dans une veine du libéralisme français attachée à conjuguer le message égalitaire de la Révolution et l’économie politique d’Adam Smith. Cette démarche trouva son ancrage dans une critique du capitalisme protectionniste considéré comme une résurrection de l’économie de privilège. Blanqui lui opposa la vigueur maintenue d’une petite entreprise « démocratique », « égalitaire », dont les produits de luxe s’imposaient sur un marché international qui, libéré de ses entraves, aurait raison des « monopoles », nouvelle aristocratie de l’argent. Ce modèle ne résista pas à la crise de 1848 qu’il vécut comme un drame. Ses témoignages courageux sur la détresse des ouvriers et de la paysannerie française lui valurent alors d’être mis à l’écart du monde académique.
Improving Cardiogenic Shock Team Activation Through Nurse Education and Alert Implementation
Authors: Krais Suzanne , Sheasby Jenelle , Banwait Jasjit , Lewis Natalie , Liu Zhaoli 
Published: December 2024

Background
Patients with cardiogenic shock have a 25% to 50% mortality rate despite the introduction of mechanical circulatory devices and coordinated medical treatment. The use of shock teams has improved outcomes for these patients.

Local Problem
A cardiovascular hospital with a multidisciplinary shock team had inconsistency and delays in recognition and diagnosis of patients with cardiogenic shock.

Methods
A nurse-led, preintervention-postintervention quality improvement project was performed in April and May 2021 and in April and May 2022 within a cardiovascular hospital in north Texas. The 2 nursing staff interventions regarding shock team activation were education and shock alert implementation. Time from first signs to diagnosis (for inpatients) and time from initial transfer request to acceptance (for transferring patients) were measured. Descriptive and statistical analyses were conducted using R, version 4.0.0 (R Foundation for Statistical Computing).

Results
The mean (SD) time to diagnosis of cardiogenic shock decreased significantly from 17.98 (28.39) hours in the preintervention group (n = 25) to 8.15 (12.26) hours in the postintervention group (n = 45; P = .045). For patients with cardiogenic shock transferring from referring hospitals, the median (IQR) time to acceptance was 1.55 (0.08-3.18) hours in the preintervention group and 0.35 (0.00-0.72) hours in the postintervention group (P &lt; .001).

Conclusions
Nursing staff interventions regarding shock team activation significantly improved the time of diagnosis and acceptance of patients with cardiogenic shock in a cardiovascular hospital, enhancing the overall quality of care provided to these patients.
Medication Transitions of Care in Trauma and Acute Care Surgery Patients
Authors: Shoulders Bethany R. , Maguigan Kelly L. , Strange Dironada K. , Lemon Stephen J. 
Published: December 2024

Background
Although the benefits of improved transitions of care regarding medications are widely known, implementation is variable among inpatient settings and populations and requires an interprofessional effort. This article reviews the body of published research on challenges with medication history taking and reconciliation for inpatients requiring treatment of traumatic injuries or surgical intervention.

Review of Evidence
A comprehensive search of PubMed and MEDLINE databases from inception to February 2021, the reference lists of qualifying articles, and PubMed’s “similar article” suggestions were used to identify publications based on the following key terms: patient transfer, transitional care, medication reconciliation, general surgery, and surgical procedures. Publications relevant to trauma and surgical patient populations were selected. Only 11 articles met the full criteria.

Implementation
The general challenges of accurate medication reconciliation at admission are also often barriers in the trauma and general surgery population. Discerning trends in the literature and evidence-based practice may be helpful.

Evaluation
The publications revealed many barriers to medication reconciliation at admission, in the intensive care unit, and at intensive care unit and hospital discharge.

Sustainability
Practices that can overcome these challenges include persistence in obtaining accurate information, paying close attention to changes in dosage or dosage forms and resumption of home medications at intensive care unit discharge, and having a follow-up plan for prescribing and deprescribing at hospital discharge.

Conclusion
Clear guidelines are needed for performing medication assessments at the bedside, including the role of each health care professional who conducts them and how the process is coordinated.
Resilience in Intensive Care Unit Nurses: An Integrative Review
Authors: Xavier Teenu , Hittle Beverly M. , Rojas-Guyler Liliana , Lee Rebecca C. 
Published: December 2024

Background
The intensive care unit environment exposes nurses to high-stress situations that potentially affect their mental and physical health. Resilience is a protective factor that can enhance the well-being of intensive care unit nurses.

Objective
To investigate the current evidence regarding resilience in intensive care unit nurses and identify factors that promote resilience.

Methods
A comprehensive literature search was undertaken for primary research conducted between January 1990 and December 2022. The updated framework of Whittemore and Knafl was used as a guide. Studies were critically appraised for methodological quality by using the Johns Hopkins Nursing evidence-based practice appraisal tool.

Results
Twelve studies were included; most used quantitative methods to measure resilience. The findings indicate that intensive care unit nurses exhibit various levels of resilience, the literature contains inconsistencies about factors affecting resilience, and resilience protects nurses against negative psychological outcomes.

Discussion
Nurses’ resilience levels should be regularly assessed to identify areas for improvement and gauge the impact of resilience interventions. By continuously monitoring and adapting support strategies on the basis of resilience changes over time, organizations can meet the needs of intensive care unit nurses.

Conclusion
More research is needed to comprehend the factors that impact resilience and devise interventions to boost resilience in intensive care nurses.
OZOILE<sup>®</sup>: evaluating its impact and future applications in inflammatory dermatological treatments
Authors: Cassaro Fabiola , Basilotta Deborah , Currò Monica , Impellizzeri Pietro , Romeo Carmelo , Arena Salvatore 
Published: December 2024

Dear Editor,
I would like to express my sincere appreciation for the publication and detailed discussion of therapies for dermatological and inflammatory conditions, as exemplified in the recent article “Onychocryptosis: a retrospective study of clinical aspects, inflammation treatment, and pain management using Ozoile as a hydrogel and cream formulation” by Vincenzo Francavilla et al. This insightful study has provided a comprehensive overview of the management of onychocryptosis, a common and often distressing condition, and has highlighted the innovative use of OZOILE® in a clinical setting.1 [...]
Relationship of lung ultrasound score with oxygenation and pulmonary mechanics in mechanically ventilated patients: An observational study
Authors: Kumar Nishant , Yadav Ayushi , Pandey Maitree 
Published: December 2024

Background and Aims:
Less than three B-lines indicate normal lung aeration, whereas multiple B-lines indicate moderate-to-severe loss of aeration. This study aimed to find a correlation between lung ultrasound score (LUSS) with oxygenation [ratio of arterial oxygen partial pressure (PaO2 in mmHg) to fractional inspired oxygen (FiO2)] and respiratory mechanics (compliance and resistance).

Methods:
In total, 101 lung ultrasounds were performed in 50 patients aged 18–60 years, requiring mechanical ventilation for at least 24 hours. Twelve region methods was used, the number of B-lines were counted in each intercostal space, and LUSS was calculated. In addition, ventilator and arterial blood gas (ABG) parameters were noted. The correlation between these variables with LUSS was evaluated using Spearman’s coefficient. A receiver operating curve analysis was performed to find the cut-off value of LUSS to predict a PaO2/FiO2 ratio of <200.

Results:
LUSS showed a negative correlation with PaO2/FiO2 ratio (ρ = 0.827, P < 0.001) and lung compliance (ρ = 0.634, P < 0.001) but a positive linear correlation with lung resistance (ρ = 0.735, P < 0.001). LUSS > 12 predicts a PaO2/FiO2 ratio of <200 with a specificity of 85.7% and a sensitivity of 97.37% (P < 0.001).

Conclusion:
LUSS is an easy and effective bedside tool for measuring lung parameters in mechanically ventilated patients. It correlates moderately with oxygenation, lung compliance, and resistance.
Evaluation of the antibacterial and wound healing efficacy of Aloe vera-coated 3-0 silk sutures in comparison to uncoated 3-0 silk sutures following flap surgery - A randomized clinical trial
Authors: Mitra Dipika , Kashid Rhea Vivek , Shetty Gaurav Prabhakar , Patil Shruti Prasanna , Shah Rohit Ajay 
Published: December 2024

Abstract:

Background:
The efficacy of surgical interventions relies on appropriate closure of the surgical site, which should also be devoid of bacteria. Plaque accumulation is a constant challenge that hampers the healing outcome. Sutures used to close the wound serve as reservoirs for microbes, increasing the risk of surgical site infections (SSIs). To avoid this, sutures can be coated with antimicrobial agents such as Aloe vera, which could be delivered to the healing site. To the best of our knowledge, there is no reported literature on using Aloe vera-coated sutures for the closure of wounds following flap surgery.

Materials and Methods:
It was a split-mouth, randomized clinical trial, in which 24 sites requiring conventional flap surgery were selected, of which 12 were assigned to Group A (uncoated sutures) and 12 to Group B (Aloe vera-coated sutures). On the 8th day, sutures were sent for microbiological analysis to count the colony-forming units (CFUs). The Early Healing Score (EHS) and Visual Analog Scale (VAS) Scores were recorded.

Results:
The intergroup comparison of VAS scores, EHSs, and CFUs between Group 1 and Group 2 was done using the Whitney U-test. It showed statistically significant differences between the two groups for the EHS and CFUs, but not for VAS scores. Thus, Group 2 shows better results as compared to Group 1.

Conclusion:
Based on the results, it was interpreted that the use of microbicidal sutures coated with Aloe vera demonstrates microbicidal properties and aids in preventing SSIs.
Estimation of noncanonical pyroptosis biomarkers gasdermin D and caspase 4 in gingiva of periodontitis and diabetes patients: An observational cross-sectional study
Authors: Arunachalam Lalitha Tanjore , Suresh Snophia , Lavu Vamsi , Vedamanickam Shankarram , Ebinezer John , Balachandran Bhavishya 
Published: December 2024

Abstract:

Background:
Periodontitis and diabetes are chronic diseases where inflammation plays a central role, with each condition exacerbating the other. Pyroptosis, an inflammatory form of programmed cell death, is implicated in periodontitis and diabetes. The activation of gasdermin D (GSDMD), a key mediator of pyroptosis, promotes cytokine release and perpetuates tissue destruction in both. However, the role of the noncanonical pyroptosis pathway mediated by caspase 4 (CASP4) remains less understood. The study aimed to determine the gene expression of noncanonical pyroptosis biomarkers CASP4 and GSDMD in periodontitis and diabetes individuals and correlate with the periodontal and diabetic parameters.

Materials and Methods:
Sixty individuals were recruited and divided into four groups: Group 1 (healthy), Group 2 (periodontitis), Group 3 (diabetes), and Group 4 (periodontitis with diabetes). Gingival tissue samples were collected from all groups, and the relative mRNA expression levels of CASP4 and GSDMD were determined using reverse transcription polymerase chain reaction. The correlation between CASP4 and GSDMD expression and periodontal parameters – plaque index (PI), gingival index (GI), probing pocket depth (PPD), and clinical attachment loss (CAL), as well as diabetic parameters – fasting blood sugar and glycated hemoglobin (HbA1C) was analyzed.

Results:
The relative mRNA expression of CASP4 and GSDMD was highest in Group 4 and lowest in Group 1. Statistical significance was observed between the groups (P ≤ 0.05) for CASP4 and GSDMD. A significant positive correlation was found between CASP4 and GSDMD expression and periodontal parameters (PI, GI, PPD, and CAL), as well as the diabetic parameter HbA1C (P ≤ 0.01).

Conclusions:
High expression of CASP4 and GSDMD was present in the gingiva of periodontitis and diabetes individuals and correlated with the diabetic and periodontal clinical parameters. This suggests that noncanonical pyroptosis contributes to periodontitis and diabetes pathogenesis through the CASP4/GSDMD axis. The inhibition of GSDMD offers a promising therapeutic approach in managing periodontitis and diabetes.