bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constructing Workstation Applications: Component Integration Strategies for a Changing Health-Care System
Authors: Deibel S. R. A. , Greenes R. A. 
Published: March 2018

AbstractA health-care workstation is the means by which a professional interacts with the information artifacts of health care. However, a major transformation is taking place in the software architecture of health-care systems that alters significantly the role of the workstation. Health-care systems are becoming more complex in response to the need to support “extended enterprises” across regions, and provide both horizontal and vertical integration capabilities. Component-based software methodologies are being introduced that match well the needs of these large systems and the component services they must integrate. In the component-based framework, a workstation functions less as a “portal” for information transactions carried out on distant host computers, and more as the “orchestrator” for tasks involved in assembling, organizing, presenting, and manipulating information. Applications residing on workstations access distributed software components that carry out encapsulated functions for the application. Componentintegration methodologies include both formal and ad hoc approaches; the principal emerging technologies are the World Wide Web (WWW), CORBA, Java, OLE, and OpenDoc. An emerging strategy appears to be that of developing application integration environments that encompass and support all of these integration methodologies. Component-based approaches also facilitate standardization at the message level, as messages to classes of components can serve to focus such standardization.
Education and Research in Health Informatics at the Faculty of Medicine of Marseille, Laboratory for Education and Research in Medical Information Processing (LERTIM)
Authors: Fieschi D. , Gouvernet J. , Joubert M. , Soula G. , Fieschi M. 
Published: March 2018

Abstract:This paper is a brief review of the research and training programs offered in Medical Informatics at the Faculty of Medicine of Marseille (LERTIM). Our laboratory teaches medical informatics and bio-statistics in the medical training curriculum, and prepares for specialised degrees and provides continuing medical education. The research projects developed by our team fall into four groups: clinical decision systems, health information systems, medical education systems, integration systems.
Charakteristische Hautveränderungen bei Rheumatoider Arthritis
Authors: Ziemer Mirjana , Müller Anne-Katrin , Oelzner Peter , Elsner Peter , Hein Gert 
Published: March 2018

Zusammenfassung
Hintergrund Das Spektrum an Hautveränderungen bei Rheumatoider Arthritis (RA) wurde in zahlreichen Übersichtsarbeiten mit dem Ziel der lückenlosen Zusammenstellung aller beobachteten Hautveränderungen dargestellt, was für den klinischen Alltag oft wenig hilfreich war und größtenteils nicht auf prospektiven Studien an größeren Patientenkollektiven basierte.
Patienten/Material und Methoden Es erfolgte eine Pubmed-Datenbankrecherche nach deutsch- und englischsprachigen, epidemiologischen, retrospektiven sowie prospektiven Studien an großen Patientenkollektiven zu Hautveränderungen bei Patienten mit RA. Diese berücksichtigen zum Teil auch Krankheitsaktivitätsscores, neuere diagnostische Parameter (anti-CCP-Antikörper) sowie neuere Medikamente (TNF-α -Blocker).
Ergebnisse Rheumaknoten sind mit einer Prävalenz zwischen 20–30% die häufigste relativ spezifische kutane Manifestation einer RA. Aktuelle Untersuchungen weisen darauf hin, dass sie häufiger bei längerer Erkrankungsdauer, Nachweis von Rheumafaktoren und Anti-CCP-Antikörper sowie unter Therapie mit Methotrexat, Leflunomid und TNF-α-Antagonisten auftreten. Eine zweite spezifische jedoch seltene Gruppe an Hautmanifestationen umfasst die ‚granulomatösen und neutrophilen Dermatitiden bei Immunkomplexerkrankungen’. Von überschätzter Bedeutung scheint hingegen das Auftreten der ‚rheumatoiden Vaskulitis’ zu sein. Die meisten „vaskulitischen“ Befunde bei Patienten mit RA lassen sich im Rahmen von Begleiterkrankungen wie chronisch-venöser Insuffizienz, arterieller Verschlusskrankheit oder Diabetes einordnen.
Schlussfolgerung Trotz zunehmend frühzeitiger Therapie der RA und dem Einsatz neuerer Medikamente wird kein Rückgang der Prävalenz von Rheumaknoten beobachtet. Deren sogar höhere Prävalenz unter Methotrexat, Leflunomid und TNF-α-Antagonisten könnte ein Hinweis dafür sein, dass Rheumaknoten durch die gegenwärtige medikamentöse Therapie nicht signifikant beeinflussbar sind. Anders als Rheumaknoten scheinen die ‚granulomatösen und neutrophilen Dermatitiden bei Immunkomplexerkrankungen’ und die ‚rheumatoide Vaskulitis’ durch die neueren Medikamente besser beeinflussbar zu sein. Wir haben den Versuch unternommen, eine Zusammen- und Gegenüberstellung der Kriterien für die spezifischeren RA-assoziierten Hautveränderungen zu erarbeiten. Tatsächlich lässt sich beginnend mit Rheumaknoten bis hin zur ‚rheumatoiden Vaskulitis’ ein fließender Übergang der klinisch-histologischen Charakteristika darstellen, der in erster Linie den Akuitätsparametern der RA sowie der Reaktionslage des Patienten zuzuschreiben ist.
Biologicals in der Rhinologie – Individualisierte Konzepte der Zukunft
Authors: Chaker Adam 
Published: March 2018

ZusammenfassungSinunasale Erkrankungen zählen mit zu den häufigsten chronischen Erkrankungen und führen zu einer erheblichen Störung der Lebensqualität, ein komorbides Asthma ist häufig. Trotz leitliniengerechter Therapie ist anzunehmen, dass mind. 20% der Patienten ihre Erkrankungssymptome nicht adäquat kontrollieren können. Neben den etablierten chirurgischen und konservativen Therapieoptionen finden sich nun vielversprechende Therapieansätze, die bspw. mittels therapeutischer Antikörper mechanistisch gezielt in die Pathophysiologie der Erkrankungen eingreifen können. Die Auswahl der geeigneten Patienten durch geeignete Biomarker und die richtige Therapie zum richtigen Stadium der Erkrankung anbieten zu können, ist das Ziel stratifizierter Medizin und eine wichtige Perspektive für die HNO.
Different Muscle Action Training Protocols on Quadriceps-Hamstrings Neuromuscular Adaptations
Authors: Ruas Cassio , Brown Lee , Lima Camila , Gregory  Haff G. , Pinto Ronei 
Published: March 2018

AbstractThe aim of this study was to compare three specific concentric and eccentric muscle action training protocols on quadriceps-hamstrings neuromuscular adaptations. Forty male volunteers performed 6 weeks of training (two sessions/week) of their dominant and non-dominant legs on an isokinetic dynamometer. They were randomly assigned to one of four groups; concentric quadriceps and concentric hamstrings (CON/CON, n=10), eccentric quadriceps and eccentric hamstrings (ECC/ECC, n=10), concentric quadriceps and eccentric hamstrings (CON/ECC, n=10), or no training (CTRL, n=10). Intensity of training was increased every week by decreasing the angular velocity for concentric and increasing it for eccentric groups in 30°/s increments. Volume of training was increased by adding one set every week. Dominant leg quadriceps and hamstrings muscle thickness, muscle quality, muscle activation, muscle coactivation, and electromechanical delay were tested before and after training. Results revealed that all training groups similarly increased MT of quadriceps and hamstrings compared to control (p<0.05). However, CON/ECC and ECC/ECC training elicited a greater magnitude of change. There were no significant differences between groups for all other neuromuscular variables (p>0.05). These findings suggest that different short-term muscle action isokinetic training protocols elicit similar muscle size increases in hamstrings and quadriceps, but not for other neuromuscular variables. Nevertheless, effect sizes indicate that CON/ECC and ECC/ECC may elicit the greatest magnitude of change in muscle hypertrophy.
The Linguistic Landscape of religious expression in Israel
Authors: Kochav Sarah 
Published: March 2018

AbstractThe religious Linguistic Landscape of the town of Safed in the Upper Galilee in Israel was studied to determine the features, properties, and boundaries signifying the spectrum of belief in the Jewish Orthodox world. In Israel, where much of everyday life is defined within a religious context, signs, posters, stickers, flags, and graffiti are a common sight and express an ongoing dynamic in the Linguistic Landscape by referencing other dimensions expressed in dress, music, and dance as well as the Internet. Expanding on the initial study is a discussion as to whether the Linguistic Landscape is utilized to express the expectation of messianic redemption through the repetition of the images of spiritual leaders and the visual representations of a religious mantra.
Meat, guns, and God
Authors: Jenks Christopher 
Published: March 2018

Abstract
A trend exists in linguistic landscape research to examine urban spaces. Interest in urban spaces is a logical expression of ongoing migratory trends. While such research is helpful in advancing scholarship, there remains a need to examine how rural areas participate in the discursive construction of society. To address the recent urbanization of sociolinguistics, this paper examines how roadside billboards in rural areas of the United States discursively construct homeland messages. Using discourse analysis and drawing from linguistic landscape scholarship, the study explores how billboards draw from banal and sentimental homeland messages to forward a contentious issue, support a political candidate, and imagine a collective American identity. These discourses feed into, and are a part of, a larger network of ideologies that fabricate authentic notions of nationhood. The findings demonstrate that roadside billboards reflect a past time that flattens the cultural diversity of a nation into a static national image.
Researching the European Parliament with Corpus-Assisted Discourse Studies
Authors: Calzada-Pérez María 
Published: March 2018

AbstractParliaments are important and complex institutions. However, they are notably under-researched within linguistics and related fields. This is certainly the case with the European Parliament (EP). Drawing both on Corpus-Assisted Discourse Studies (CADS) and prior, manual research on parliamentary communication, this paper proposes and applies an analytical protocol to examine EP speeches. Although these are disseminated in various forms and through dissimilar means (e.g., live at the EP; the audiovisual format via streaming or recorded videos; or published as parliamentary proceedings), here we focus on proceedings – one of the EP’s main sources of official representation. Following the EP’s (unique) practice, where official proceedings do not distinguish between original and translated speeches but consider all texts of equal (legal) status, this study delves into all speech production in English, without separating source and target texts. In the most orthodox of CADS traditions, analysis proceeds from micro and macro-levels of texts into the macro-context (unlike other academic approaches, in which it proceeds in the opposite direction). This direction forces us to move from tangible, specific data to the enveloping setting in which these data are exchanged.
Analysis of the new examination process and German tests for sworn translators in Spain
Authors: Castillo Bernal María Pilar 
Published: March 2018

Abstract
The recent changes in the legislation on sworn translators and interpreters in Spain (Royal Decree 2002/2009, Order AEC/2125/2014) have brought about some modifications in the requisites and the access tests for this professional figure. Following the Resolution of 19 January 2015, new tests were conducted in 2015 in order to qualify translators and interpreters. This paper aims to analyze the new format of examination and the statistics of success of the candidates, with special focus on the German language. The current process shall also be compared to the now extinct academic process of qualification of sworn translators and interpreters in the framework of official translation degrees in Spain, in order to ascertain the most appropriate qualification method.
Hybrid texts and their influence on the work carried out by specialized translators
Authors: Pajares Nievas José Sergio , Peñalver Elena Alcalde 
Published: March 2018

Abstract
A genre can be defined as a conventionalized text form that has a specific function. Nevertheless, the complexity and uses given to texts have contributed to create new relations between genres, resulting in what we call hybrid texts. The traditional categorization that is commonly perceived as independent sections has to be analyzed and treated in a different way. In this study, we abandon this idea to show the importance of hybrid texts or genres and how these relations can determine the tasks and strategies followed by professional translators. In this case, we will focus on medical-legal texts, financial-legal texts and also other texts combining these three disciplines.
The audio describer as a cultural mediator
Authors: Sanz-Moreno Raquel 
Published: March 2018

AbstractAudio Description (AD) is a modality of audiovisual translation that consists of making cultural products accessible to people who are blind or partially-sighted. Our study focuses on the contrastive analysis of the AD of four films in English and Spanish, our objective being to determine how the same visual cultural reference is described in two languages and for two target cultures. Using a descriptive methodology, we categorise and analyse cultural references followingDíaz Cintas and Remael’s (2007)classification and determine the translation strategies used. Our research shows that the decisions that the describer makes are conditioned by the distance, not only geographical but above all cultural, that exists between the audience and the culture that is reflected in the film. The describer becomes a mediator between cultures; that is why the greater the cultural distance, the higher their presence and involvement.
The multilingual university website (MUW) genre ecology
Authors: Ezpeleta-Piorno Pilar , Borja Albi Anabel 
Published: March 2018

Abstract
This article analyzes the content of Spanish university websites and the processes involved in translating them, with the aim of identifying the challenges internationalisation poses for these institutions and the technical, organisational, and translation-related solutions that have been adopted for managing their multilingual content, particularly in the case of universities in autonomous communities with two official languages. It examines the communicative situation of the multilingual university website (MUW) genre by applying textual genre analysis, with special emphasis on translation and localisation processes. The empirical study of the macrostructures, multilingual content, and strategies used by each university to translate its website is articulated through the notion of a genre ecology, as a complex conglomerate of genres based on distributed cognition and shared authorship. The analysis shows that the processes involved in creating multilingual content require adopting comprehensive translation and localisation strategies, establishing sole decision-makers for translation management and quality control, and providing the necessary resources to ensure the multifunctionality, dynamicity, interactivity, and adaptability we have identified in monolingual university websites. Finally, we offer suggestions for improving the creation, management and control of multilingual content, and define the profiles of the specialized translators required for this type of institutional website.
The syntax of nominal modification in Italian Sign Language (LIS)
Authors: Mantovan Lara , Geraci Carlo 
Published: March 2018

AbstractIn this paper, we investigate structural aspects of nominal modification in Italian Sign Language (LIS), a language with a relatively flexible word order. In order to tackle the issue, this study combines different approaches, including generalizations from typological universals on word order, their formal counterparts, and a variationist approach to language facts. Data come from the largest corpus of LIS currently available. Despite the absence of categorical rules, our mixed approach shows that LIS data are consistent with the general tenets of nominal modification. Results from the statistical analysis indicate that the attested language-internal variability is constrained both by linguistic and social factors. Specifically, a fine-grained structure of nominal modification is able to capture the internal variability of LIS. Processing effects, age, gender, and early exposure to the language also play a relevant role in determining order preferences.
Circulating extracellular vesicles as potential biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis: an exploratory pilot study
Authors: Castro‐Marrero Jesús , Serrano‐Pertierra Esther , Oliveira‐Rodríguez Myriam , Zaragozá Maria Cleofé , Martínez‐Martínez Alba , Blanco‐López María del Carmen , Alegre José 
Published: March 2018

ABSTRACTChronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME) is an acquired, complex and multisystem condition of unknown etiology, no established diagnostic lab tests and no universally FDA‐approved drugs for treatment. CFS/ME is characterised by unexplicable disabling fatigue and is often also associated with numerous core symptoms. A growing body of evidence suggests that extracellular vesicles (EVs) play a role in cell‐to‐cell communication, and are involved in both physiological and pathological processes. To date, no data on EV biology in CFS/ME are as yet available. The aim of this study was to isolate and characterise blood‐derived EVs in CFS/ME. Blood samples were collected from 10 Spanish CFS/ME patients and 5 matched healthy controls (HCs), and EVs were isolated from the serum using a polymer‐based method. Their protein cargo, size distribution and concentration were measured by Western blot and nanoparticle tracking analysis. Furthermore, EVs were detected using a lateral flow immunoassay based on biomarkers CD9 and CD63. We found that the amount of EV‐enriched fraction was significantly higher in CFS/ME subjects than in HCs (p = 0.007) and that EVs were significantly smaller in CFS/ME patients (p = 0.014). Circulating EVs could be an emerging tool for biomedical research in CFS/ME. These findings provide preliminary evidence that blood‐derived EVs may distinguish CFS/ME patients from HCs. This will allow offer new opportunities and also may open a new door to identifying novel potential biomarkers and therapeutic approaches for the condition.
Improved resolution in extracellular vesicle populations using 405 instead of 488 nm side scatter
Authors: McVey Mark J. , Spring Christopher M. , Kuebler Wolfgang M. 
Published: March 2018

ABSTRACTImprovements in identification and assessment of extracellular vesicles (EVs) have fuelled a recent surge in EV publications investigating their roles as biomarkers and mediators of disease. Meaningful scientific comparisons are, however, hampered by difficulties in accurate, reproducible enumeration and characterization of EVs in biological fluids. High‐sensitivity flow cytometry (FCM) is presently the most commonly applied strategy to assess EVs, yet its utility is limited by variant ability to resolve smaller EVs. Here, we propose the use of 405 nm (violet) wavelength lasers in place of 488 nm (blue) for side scatter (SSC) detection to obtain greater resolution of EVs using high‐sensitivity FCM. To test this hypothesis, we modelled EV resolution by violet versus blue SSC in silico and compared resolution of reference beads and biological EVs from plasma and bronchoalveolar lavage (BAL) fluid using either violet or blue wavelength SSC EV detection. Mie scatter modelling predicted that violet as compared to blue SSC increases resolution of small (100–500 nm) spherical particles with refractive indices (1.34–1.46) similar to EVs by approximately twofold in terms of light intensity and by nearly 20% in SSC signal quantum efficiency. Resolution of reference beads was improved by violet instead of blue SSC with two‐ and fivefold decreases in coefficients of variation for particles of 300–500 nm and 180–240 nm size, respectively. Resolution was similarly improved for detection of EVs from plasma or BAL fluid. Violet SSC detection for high‐sensitivity FCM allows for significantly greater resolution of EVs in plasma and BAL compared to conventional blue SSC and particularly improves resolution of smaller EVs. Notably, the proposed strategy is readily implementable and inexpensive for machines already equipped with 405 nm SSC or the ability to accommodate 405/10 nm bandpass filters in their violet detector arrays.
Awareness of antiplatelet resistance in patient with repeated episodes of thrombotic events
Authors: Dalimunthe N N , Hamonangan R , Antono D , Prasetya I , Rusdi L 
Published: March 2018

Abstract
Antiplatelet has been the cornerstones management of acute coronary syndrome. However, numbers of patients on these agents had episodes of adverse cardiovascular events. A 65-year-old woman post cardiac coronary bypass surgery on dual antiplatelet therapy, Aspirin, and Clopidogrel underwent several episodes of thrombotic events despite good adhered to thedailyantiplatelet regimen.These recurrent events had led to clinical suspicious of antiplatelet resistance. Platelet function test was performed which indicates a poor platelet response to Clopidogrel. Clopidogrelwas discontinued and Ticagrelor was prescribed together with Aspirin. During two months of follow up, there is no episode of chest discomfort.
Positive correlation between retinol binding protein 4 (RBP4) and triglyceride level in central obesity
Authors: Oktaria S , Sari D K , Dalimunthe D , Eyanoer P C 
Published: March 2018

AbstractObesity has become an epidemic in both developed and developing countries. Central obesity considered a risk factor that is closely related to several chronic diseases. Central obesity is associated with elevated triglyceride levels and associated with RBP4 which can lead to insulin resistance. Increased level of RBP4 can cause lipid metabolism disorders and can become a marker for insulin resistance and metabolic syndrome. This study aims to find the correlation of RBP4 with triglycerides and Apo B100 in central obesity. It was a cross- sectional study on 46 subjects with central obesity, aged 20-50 years old. Blood samples were taken in cubital vein and examined for RBP4 and triglyceride levels. Data analysis was performed using Spearman correlation test. The results showed that gender frequency distribution showed little difference between men and women, i. e., men 43.5% and women 56.5%. RBP4 level was positively correlated with triglyceride (r = 0.48) and statistically significant (p = 0.001). The rbp4 level was positively correlated with triglyceride, indicating the role of RBP4 on high triglyceride level in central obesity.
Viruses: A Very Short Introduction
Authors: Crawford Dorothy H. 
Published: March 2018

Abstract
Viruses: A Very Short Introduction outlines the origins, structure, and method of infection of a vast variety of viruses and demonstrates how clever these entities appear to be. It explains the vital role viruses play in the ocean’s delicate ecosystem and discusses the impact of global warming, which is increasing the range of vector-transmitted viruses such as dengue, yellow fever, and West Nile virus. The recent Ebola and Zika epidemics, as well as Middle East Respiratory Syndrome, are also discussed. Can we ever live in harmony with viruses? This VSI considers the ways in which we may need to adapt to prevent emerging viruses with devastating consequences.