bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifikasi Bakteri dan Faktor Risiko Kejadian Pressure Ulcer di RSUD AWS Samarinda
Authors: Setiani Diah , Imamah Indah Nur 
Published: July 2019

Adanya pressure ulcer mengganggu proses pemulihan pasien, diikuti komplikasi dengan nyeri dan infeksi sehingga menambah panjang lama perawatan. Pressure ulcer menimbulkan sebuah ancaman dalam pelayanan kesehatan karena insidennya semakin hari semakin meningkat (Spilsbury, et al, 2010). Tujuan penelitian ini, mengetahui gambaran bakteri pada pressure ulcer dan faktor kejadian pressure ulcer di RSUD AWS Samarinda.
Metode penelitian yang digunakan adalah penelitian deskriptif. Dimana populasi adalah semua pasien yang mengalami pressure ulcer. Teknik pengambilan sampel (sampling) menggunakan metode accidental sampling dilaksanakan di RSUD AWS Samarinda pada bulan Oktober Tahun 2017 meliputi ruang HCU, stroke center, anggrek, angsoka dan flamboyan sebanyak 11 orang. Variable dalam yang diukur penelitian ini adalah identifikasi bakteri, faktor risiko (persepsi sensori, kelembaban, aktifitas, mobilisasi, nutrisi, gesekan dan robekan). Analisis yang digunakan adalah analisis univariat yaitu dalam bentuk data yang disajikan dalam bentuk tabel distribusi frekuensi dan persentase, meliputi karakteristik responden dan faktor risiko skala braden. Penelitian ini telah mendapatkan persetujuan kelakayan etik dari komisi etik penelitian kesehatan RSUD A. Wahab Sjahranie Samarinda dengan nomor 030/KEPK-AWS/XI/2017 .
Hasil penelitian yang dilakukan pada 11 orang responden didapatkan: Jenis kuman gram negative paling banyak terdapat di pressure ulcer sebesar (81 %) Acinetobacter sp adalah mikroorganisme yang paling dominan terdapat diluka pressure, sebanyak 63,6 % responden memiliki persepsi dan sensori normal, sebanyak 63,6 % kelembaban responden adalah selalu basah, sebanyak 81,8% kegiatan pasien pressure ulcer adalah bedrest, sebanyak 63,6% mobilitas responden adalah imobilisasi total, sebanyak 54,5% kondisi nutrisi responden adalah cukup, sebanyak 72,7% gesekan dan robekan reponden memiliki masalah. Bagi para pemberi pelayanan diharapkan dapat melakukan pengkajian faktor kejadian pressure ulcer serta dapat mengendalikan infeksi pada pasien dengan ketergantungan total/ bedrest sehingga angka kejadian dapat berkurang.
Constructed wetlands as post treatment of a decanter digester followed by an anaerobic filter
Authors: Reis Wilhan Douglas , Santos Aldecy De Almeida , Oliveira Eduarda Da Conceição , Ito João Batista 
Published: July 2019

The amount of wastewater has increased due to the considerable expansion of higher education institutions. When wastewater is released without treatment or with inefficient treatment, it causes significant water pollution. In this context, this study evaluated the performance of Constructed Wetlands as a post-treatment of a decanter digester followed by an anaerobic filter, operated with effluent from the Federal University of Mato Grosso, Cuiabá Campus, Mato Grosso State. Four wetlands were constructed to develop the research: planted with Typha domingensis, planted with Heliconia psittacorum, planted with Pontederia parviflora, and not planted. The following physicochemical parameters were analyzed: Color, Turbidity, pH, Temperature, Total Solids, Total Dissolved Solids (TDS), Biochemical Oxygen Demand (BOD), Chemical Oxygen Demand (COD), Total Nitrogen, Sulfate, Nitrate and Nitrite. The results show an organic matter removal efficiency with mean removal results: 70% BOD5 for TCW, HCW and PCW; and COD 76% for PCW. The mean removal of total phosphorus was 78% for PCW and 92% NO-2, as macronutrients. Analysis of variance ANOVA shows significance in the results of TDS, SO4 and COD removal.
Prayers for Bobby (Orações para Bobby)
Authors: Andrade Carla Andreia Alves , Pires Alberto Magalhães , Sandes Lívia Guimarães , Lira Taiwana Batista Buarque , De Araújo Ednaldo Cavalcante 
Published: July 2019

O Filme Orações para Bobby é um filme com abordagem das pessoas Lésbicas, Gays, Bissexuais, Travestis e Transexuais (LGBTs) que demonstra por meio de cenas impactantes, emocionantes e sensíveis, a comovente história de um homossexual, na adolescência, e sua trajetória de vida. Aborda a relação familiar, religiosa, psicológica e com as relações sociais vivenciadas após se identificar homossexual. Baseado em fatos reais, o filme, teve sua origem a partir do livro que possui o título "Prayers for Bobby: A Mother's Coming to Terms with the Suicide of Her Gay Son", em 1995, com diversas passagens do diário de Bobby e que ainda não possui tradução em português.
Acesso, acolhimento e estratégia saúde da família: satisfação do usuário
Authors: De Lira Letycia Beatriz Souza , Santos Débora De Souza , Neves Sabrina Joany Felizardo , Nagliate Patrícia De Carvalho , DE LIRA LETYCIA BEATRIZ SOUZA , Pereira Elainey De Albuquerque Tenório , Cavalcante Marília Vieira 
Published: July 2019

Objetivo: avaliar o grau de satisfação dos usuários em relação ao Acesso e Acolhimento oferecidos pela Estratégia de Saúde da Família de uma capital do nordeste brasileiro. Método: estudo transversal, descritivo, exploratório, de abordagem quantitativa realizado entre setembro de 2015 e março de 2016, que utilizou questionário de Kloetzel, que aborda questões referentes à qualidade da última consulta no serviço de saúde. Compuseram a amostra 202 indivíduos cadastrados na Unidade de Saúde. Os dados foram consolidados, tabulados e sistematizados com auxílio dos programas Google Documentos, Microsoft Excel e SPSS versão 13.0. Para avaliar a relação entre dados categóricos utilizou-se o teste de qui-quadrado, e para a comparação de média entre os grupos o teste de T para amostras independentes. Resultados: o grau de satisfação dos usuários é positivo, a maior parte dos usuários classifica os serviços prestados como “muito bom” ou “bom”. Os pontos de maior satisfação foram quanto à “forma de agendamento da consulta” (59%) e “facilidade de acesso” à unidade (54,5%), enquanto que o “tempo despendido na sala de espera” foi o único ponto de insatisfação (62,4%). O grau de satisfação dos usuários não sofreu alterações segundo o perfil sóciodemográfico. Conclusões: o estudo contribui com o tema pesquisado instrumentalizando os profissionais de saúde e gestores quanto à relação existente entre acesso, acolhimento e satisfação do usuário, possibilitando caminhos para a melhoria da qualidade dos serviços da Estratégia Saúde da Família. Descritores: Satisfação do Paciente; Atenção Primária à Saúde; Estratégia de Saúde da Família; Acesso aos Serviços de Saúde.
Construction and integrated analysis of crosstalking ceRNAs networks in laryngeal squamous cell carcinoma
Authors: Liu Yuehui , Ye Fan 
Published: July 2019

BackgroundLaryngeal squamous cell carcinoma (LSCC) is one of the most common malignant tumours of the head and neck. Recent evidence has demonstrated that lncRNAs play important roles in tumour progression and could be used as biomarkers for early diagnosis, prognosis, and potential therapeutic targets. The “competitive endogenous RNA (ceRNA)” hypothesis states that lncRNAs competitively bind to miRNAs through their intramolecular miRNA reaction elements (MREs) to construct a wide range of ceRNA regulatory networks. This study aims to predict the role of ceRNA network in LSCC, for advancing the understanding of underlying mechanisms of tumorigenesis.Material and MethodsIn this study, the functions of lncRNAs as ceRNAs in LSCC and their prognostic significance were investigated via comprehensive integrated expression profiles data of lncRNAs, mRNAs, and miRNAs obtained from The Cancer Genome Atlas (TCGA). Protein–protein interaction, gene ontology, pathway, and Kaplan–Meier curves analysis were used to profile the expression and function of altered RNAs in LSCC.ResultsAs a result, 889 lncRNAs, 55 miRNAs and 1946 mRNAs were found to be differentially expressed in LSCC. These altered mRNAs were mainly involved in extracellular matrix organization, calcium signaling, and metabolic pathways. To study the regulatory function of lncRNAs, an lncRNA-mediated ceRNA network was constructed. This ceRNA network included 61 lncRNAs, seven miRNAs and seven target mRNAs. Of these RNAs, lncRNAs (TSPEAR-AS, CASK-AS1, MIR137HG, PART1, LSAMP-AS1), miRNA (has-mir-210) and mRNAs (HOXC13, STC2, DIO1, FOXD4L1) had a significant effect on the prognosis of LSCC.ConclusionThe results of this study broaden the understanding of the mechanisms by which lncRNAs are involved in tumorigenesis. Furthermore, five lncRNAs (TSPEAR-AS, CASK-AS1, MIR137HG, PART1, LSAMP-AS1) were identified as potential prognostic biomarkers and therapeutic targets for LSCC. These results provide a basis for further experimental and clinical research.
Systems of Communicating Sexual and Reproductive Health Issues between Hearing Parents and Their Deaf Adolescent Children in Western Kenya
Authors: Ochieng’ Justine Anyango , Atieli Harrysone , Abongo Bernard , Ouma Collins 
Published: July 2019

Background: Deaf adolescent children face greater challenges in accessing information, particularly on sexual and reproductive health (SRH) than those with other forms of disability. Parents therefore represent the first source of information for such children. However, the extent of this and systems of communication used by these parents remain largely unknown. Therefore, it is against this backdrop that we sought to study systems of parents communicating SRH issues to their children.
Methods: A mixed method design was used to collect quantitative and qualitative data on the system of communication used by the sign-language illiterate parents respectively, their perceptions on such discussions and the choice of system of communication. A sample size of 384 parent-child pairs was selected using systematic probability sampling for the quantitative component of the study. For the qualitative component, respondents were recruited using a purposive convenience sampling method which though non-representative, allowed the investigator to choose participants best suited for the intended objective. The study was carried out in ten schools; randomly selected from a sample frame comprising of a list of primary and secondary schools for deaf children within the former Nyanza region of western Kenya. Data was collected using anonymized questionnaires and Focus Group Discussions (FGDs).
Results: Majority of the male parents 90 (23.4%) were in the age range of 51-60 years, while most female parents 134 (34.8%) were in the age category of 40-50 years. Nearly 70% (67%) of the children were in the age range of 15-19 years. Overall, use of picture came out as the main mode/format of communication (33%); with females using it more (23%) compared to males 12.3%. Lip-reading (children reading the lips of their parents), was principally used by male parents. 32(8.3%) parents falling within the age group 41-50 and 51-60 years felt that the information they had on SRH was inadequate. More so, in a qualitative interview, most parents were not satisfied that they had provided enough information to their children on matters of SRH due to communication barrier. Some of the emerging themes from the FGDs were: parents lack a proper approach of conveying SRH information to their deaf adolescent children, unresponsiveness/lack of interest by deaf adolescent children, wrong translation of information conveyed and insufficient time with their deaf adolescent children to pass across these messages.
Conclusion: Children with hard hearing are less likely to get adequate information on SRH than their counterparts with no hearing impairment.
Linear Summing Formulas of Generalized Pentanacci and Gaussian Generalized Pentanacci Numbers
Authors: Soykan Yüksel 
Published: July 2019

In this paper, we present linear summation formulas for generalized Pentanacci numbers and generalized Gaussian Pentanacci numbers. Also, as special cases, we give linear summation formulas of Pentanacci and Pentanacci-Lucas numbers; Gaussian Pentanacci and Gaussian Pentanacci-Lucas numbers. We present the proofs to indicate how these formulas, in general, were discovered. Of course, all the listed formulas may be proved by induction, but that method of proof gives no clue about their discovery.
The Comparison of the Effect of Repetitive Doses of Succinylcholine and Thiopental Sodium on the Duration and Severity of Seizure in Electro Convulsive Therapy: Randomized Clinical Trial
Authors: Nanaei Farhad , Bahrami Hadi , Kasani Aziz 
Published: July 2019

Background and Aim: Regarding the controversial results on the effects of anesthetics, especially thiopental sodium, on the duration and severity of seizure and the lack of adequate information on the use of doses of anesthetic and paralysing drugs during ECT, this study was designed to determine the effect of repetitive doses of succinylcholine and Thiopental sodium was administered on the duration and severity of seizure during ECT.
Materials and Methods: The present study was a one-blind randomized clinical trial on patients admitted to the psychiatric ward of Dezful Ganjavian Hospital. The research samples were selected after informed consent and entry criteria. Then, the samples were randomly assigned to two groups. In one group, succinylcholine dose was repeated (one third of the initial dose), and in the other group, the dose of thiopental sodium was repeated (one third of the initial dose). In all patients, seizure duration based on EEG monitoring and severity of seizure was determined by the psychiatrist based on the symptoms of the patient during seizure.
Results: There was a significant difference between the quality of seizure in the two treatment groups after the intervention. There was a strong and good seizure in the thiopental sodium group (p <0.0001). There was a significant difference between the variables of seizure status in comparison with the previous shock in the two treatment groups after the intervention (p <0.0001). The duration of seizure was higher in thiopental sodium treatment group, but no significant difference was observed (p = 0.82).
Conclusion: The results of this study showed that the duration and quality of seizure was better in patients requiring repetitive doses of hypnotic drugs (Thiopental Sodium), which was used to repeat the dose of muscle relaxant (succinylcholine).
Analysis of the functional capacity outcome measures for myotonic dystrophy
Authors: Jimenez‐Moreno Aura Cecilia , Nikolenko Nikoletta , Kierkegaard Marie , Blain Alasdair P. , Newman Jane , Massey Charlotte , Moat Dionne , Sodhi Jas , Atalaia Antonio , Gorman Grainne S. , Turner Chris , Lochmüller Hanns 
Published: July 2019

AbstractObjectivesDefining clinically relevant outcome measures for myotonic dystrophy type 1 (DM1) that can be valid and feasible for different phenotypes has proven problematic. The Outcome Measures for Myotonic Dystrophy (OMMYD) group proposed a battery of functional outcomes: 6‐minute walk test, 30 seconds sit and stand test, timed 10 m walk test, timed 10 m walk/run test, and nine‐hole peg test. This, however, required a large‐scale investigation,MethodsA cohort of 213 patients enrolled in the natural history study, PhenoDM1, was analyzed in cross‐sectional analysis and subsequently 98 patients were followed for longitudinal analysis. We aimed to assess: (1) feasibility and best practice; (2) intra‐session reliability; (3) validity; and (4) behavior over time, of these tests.ResultsOMMYD outcomes proved feasible as 96% of the participants completed at least one trial for all tests and more than half (n = 113) performed all three trials of each test. Body mass index and disease severity associate with functional capacity. There was a significant difference between the first and second trials of each test. There was a moderate to strong correlation between these functional outcomes and muscle strength, disease severity and patient‐reported outcomes. All outcomes after 1 year detected a change in functional capacity except the nine‐hole peg test.ConclusionsThese tests can be used as a battery of outcomes or independently based on the shown overlapping psychometric features and strong cross‐correlations. Due to the large and heterogeneous sample of this study, these results can serve as reference values for future studies.
Prosody instruction intervention as a means to improved reading comprehension
Authors: Cypert Rick , Petro Marilyn 
Published: July 2019

SummaryThe relationship between prosody and comprehension, previously demonstrated in K–12 students, was examined in university students enrolled in first‐year writing classes. Students completed the Gray Oral Reading Test‐5 both before and after an expressive reading intervention (ER) or no oral reading instruction (NI). Throughout the semester, the ER students marked an excerpt of text for prosodic signals and read it aloud with a partner. Training and practice in expressive reading led to a significant improvement in the normed Oral Reading Index score. Specifically, ER participants demonstrated improved accuracy, fluency, and reading comprehension in comparison with NI participants. The significant relationship between accuracy and comprehension in the ER condition suggests that expressive reading instruction strengthened student ability to read words accurately and, in turn, comprehend the material better than students in the NI condition. Expressive reading practices are recommended to engage students more deeply with the text.
Epitaxial Oxides on Semiconductors: From Fundamentals to New Devices
Authors: Kumah Divine P. , Ngai Joseph H. , Kornblum Lior 
Published: July 2019

AbstractFunctional oxides are an untapped resource for futuristic devices and functionalities. These functionalities can range from high temperature superconductivity to multiferroicity and novel catalytic schemes. The most prominent route for transforming these ideas from a single device in the lab to practical technologies is by integration with semiconductors. Moreover, coupling oxides with semiconductors can herald new and unexpected functionalities that exist in neither of the individual materials. Therefore, oxide epitaxy on semiconductors provides a materials platform for novel device technologies. As oxides and semiconductors exhibit properties that are complementary to one another, epitaxial heterostructures comprised of the two are uniquely poised to deliver rich functionalities. This review discusses recent advancements in the growth of epitaxial oxides on semiconductors, and the electronic and physical structure of their interfaces. Leaning on these fundamentals and practicalities, the material behavior and functionality of semiconductor–oxide heterostructures is discussed, and their potential as device building blocks is highlighted. The culmination of this discussion is a review of recent advances in the development of prototype devices based on semiconductor–oxide heterostructures, in areas ranging from silicon photonics to photocatalysis. This overview is intended to stimulate ideas for new concepts of functional devices and lay the groundwork for their realization.
Differentiation of Rat Mesenchymal Stem Cells toward Osteogenic Lineage on Extracellular Matrix Protein Gradients
Authors: Rasi Ghaemi Soraya , Delalat Bahman , Cavallaro Alex , Mierczynska‐Vasilev Agnieszka , Vasilev Krasimir , Voelcker Nicolas H. 
Published: July 2019

AbstractThis report addresses the issue of optimizing extracellular matrix protein density required to support osteogenic lineage differentiation of mesenchymal stem cells (MSCs) by culturing MSCs on surface‐bound density gradients of immobilized collagen type I (COL1) and osteopontin (OPN). A chemical surface gradient is prepared by tailoring the surface chemical composition from high hydroxyl groups to aldehyde groups using a diffusion‐controlled plasma polymerization technique. Osteogenesis on the gradient surface is determined by immunofluorescence staining against Runx2 as an early marker and by staining of calcium phosphate deposits as a late stage differentiation marker. The Runx2 intensity and calcified area increase with increasing COL1 density up to a critical value corresponding to 124.2 ng cm−2, above which cell attachment and differentiation do not rise further, while this critical value for OPN is 19.0 ng cm−2. This gradient approach may facilitate the screening of an optimal biomolecule surface density on tissue‐engineered scaffolds, implants, or tissue culture ware to obtain the desired cell response, and may generate opportunities for more cost‐effective regenerative medicine.
Microneedle‐Based Generation of Microbubbles in Cancer Tumors to Improve Ultrasound‐Assisted Drug Delivery
Authors: Zandi Ashkan , Khayamian Mohammad Ali , Saghafi Mohammad , Shalileh Shahriar , Katebi Pouyan , Assadi Sepanta , Gilani Ali , Salemizadeh Parizi Mohammad , Vanaei Shohreh , Esmailinejad Mohammad Reza , Abbasvandi Fereshteh , Hoseinpour Parisa , Abdolahad Mohammad 
Published: July 2019

AbstractProduction of local microbubbles (MBs) with dense distribution in tumor environment is achieved by developing an integrated electrochemical stimulator on a microfabricated silicon needle covered by zinc‐oxide nanowires (ZnONWs). MBs are then exploded by external ultrasonic actuation, which induce microcavitations in tumor cells followed by direct entrance of anticancer drugs into cancer cells. This system, named ZnO nanowire‐based microbubble generator probe (ZnONW‐MGP), is tested on tumorized mice models (by MC4L2 breast cell lines). Mice treated by ZnONW‐MGP have ≈82% reduction in tumor size within 10 days with just 25% of conventional dose of paclitaxel while in the absence of the system, they have just a 15% reduction in tumor size. Presence of ZnO nanostructures on microneedles strongly reduces the size of MBs and enhances the efficacy of the sonoporation.
Molecular Mass‐Dependent Resorption and Bone Regeneration of 3D Printed PPF Scaffolds in a Critical‐Sized Rat Cranial Defect Model
Authors: Nettleton Karissa , Luong Derek , Kleinfehn Alex P. , Savariau Laura , Premanandan Christopher , Becker Matthew L. 
Published: July 2019

AbstractThe emergence of additive manufacturing has afforded the ability to fabricate intricate, high resolution, and patient‐specific polymeric implants. However, the availability of biocompatible resins with tunable resorption profiles remains a significant hurdle to clinical translation. In this study, 3D scaffolds are fabricated via stereolithographic cDLP printing of poly(propylene fumarate) (PPF) and assessed for bone regeneration in a rat critical‐sized cranial defect model. Scaffolds are printed with two different molecular mass resin formulations (1000 and 1900 Da) with narrow molecular mass distributions and implanted to determine if these polymer characteristics influence scaffold resorption and bone regeneration in vivo. X‐ray microcomputed tomography (µ‐CT) data reveal that at 4 weeks the lower molecular mass polymer degrades faster than the higher molecular mass PPF and thus more new bone is able to infiltrate the defect. However, at 12 weeks, the regenerated bone volume of the 1900 Da formulation is nearly equivalent to the lower molecular mass 1000 Da formulation. Significantly, lamellar bone bridges the defect at 12 weeks with both PPF formulations and there is no indication of an acute inflammatory response.