bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wearable sensors for monitoring the internal and external workload of the athlete
Authors: Seshadri Dhruv R. , Li Ryan T. , Voos James E. , Rowbottom James R. , Alfes Celeste M. , Zorman Christian A. , Drummond Colin K. 
Published: July 2019

AbstractThe convergence of semiconductor technology, physiology, and predictive health analytics from wearable devices has advanced its clinical and translational utility for sports. The detection and subsequent application of metrics pertinent to and indicative of the physical performance, physiological status, biochemical composition, and mental alertness of the athlete has been shown to reduce the risk of injuries and improve performance and has enabled the development of athlete-centered protocols and treatment plans by team physicians and trainers. Our discussions in this review include commercially available devices, as well as those described in scientific literature to provide an understanding of wearable sensors for sports medicine. The primary objective of this paper is to provide a comprehensive review of the applications of wearable technology for assessing the biomechanical and physiological parameters of the athlete. A secondary objective of this paper is to identify collaborative research opportunities among academic research groups, sports medicine health clinics, and sports team performance programs to further the utility of this technology to assist in the return-to-play for athletes across various sporting domains. A companion paper discusses the use of wearables to monitor the biochemical profile and mental acuity of the athlete.
Associations ofSLC6A20genetic polymorphisms with Hirschsprung’s disease in a Southern Chinese population
Authors: Xie Xiaoli , He Qiuming , Huang Lihua , Li Le , Yao Yuxiao , Xia Huimin , Zhao Jinglu , Zhong Wei , Zhang Yan 
Published: July 2019

AbstractHirschsprung’s disease (HSCR) is a neurodevelopmental disorder characterized by the absence of nerves in intestine with strong genetic components. SLC6A20 was found to be associated with HSCR in Korean population waiting for replication in an independent cohort. In the present study, ten single nucleotide polymorphisms (SNPs) in the SLC6A20 were selected from Southern Chinese with 1470 HSCR cases and 1473 ethnically matched healthy controls. Our results indicated that SNP rs7640009 was associated with HSCR and SLC6A20 has a gene–dose effect in the extent of the aganglionic segment during enteric nervous system (ENS) development. It is the first time to reveal the relationship between SNP rs2191026 and HSCR-associated enterocolitis (HAEC) susceptibility.
Fatty acid oxidation inhibitor etomoxir suppresses tumor progression and induces cell cycle arrest via PPARγ-mediated pathway in bladder cancer
Authors: Cheng Songtao , Wang Gang , Wang Yejinpeng , Cai Liwei , Qian Kaiyu , Ju Lingao , Liu Xuefeng , Xiao Yu , Wang Xinghuan 
Published: July 2019

Abstract
Tumor cells rely on aerobic glycolysis as their main energy resource (Warburg effect). Recent research has highlighted the importance of lipid metabolism in tumor progression, and certain cancers even turn to fatty acids as the main fuel. Related studies have identified alterations of fatty acid metabolism in human bladder cancer (BCa). Our microarray analysis showed that fatty acid metabolism was activated in BCa compared with normal bladder. The free fatty acid (FFA) level was also increased in BCa compared with paracancerous tissues. Inhibition of fatty acid oxidation (FAO) with etomoxir caused lipid accumulation, decreased adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide phosphate (NADPH) levels, suppressed BCa cell growth in vitro and in vivo, and reduced motility of BCa cells via affecting epithelial–mesenchymal transition (EMT)-related proteins. Furthermore, etomoxir induced BCa cell cycle arrest at G0/G1 phase through peroxisome proliferator-activated receptor (PPAR) γ-mediated pathway with alterations in fatty acid metabolism associated gene expression. The cell cycle arrest could be reversed by PPARγ antagonist GW9662. Taken together, our results suggest that inhibition of FAO with etomoxir may provide a novel avenue to investigate new therapeutic approaches to human BCa.
Circumstellar envelopes of semi-regular long-period variables: mass-loss rate estimates and general model fitting of the molecular gas
Authors: Díaz-Luis J. J. , Alcolea J. , Bujarrabal V. , Santander-García M. , Castro-Carrizo A. , Gómez-Garrido M. , Desmurs J.-F. 
Published: July 2019

Aims. We aim to study the main properties of a volume-limited unbiased sample of well-characterized semi-regular variables (SRs) in order to clarify important issues that need to be further explained, such as the formation of axially symmetric planetary nebulae (PNe) from spherical circumstellar envelopes (CSEs), which takes place during the mass-loss process along the asymptotic giant branch (AGB) phase.
Methods. We present new high-S/N IRAM 30 m observations of the 12CO J = 2–1, 12CO J = 1–0, and 13CO J = 1–0 lines, in a volume-limited sample of SRs for which the HIPPARCOS distances are between 100 and 500 pc and the declinations are above −25°. We analyzed the data by characterizing the main properties of the CSEs. The 12CO J = 2–1 data were used to study the profiles, while the 12CO J = 1–0 data were used to estimate mass-loss rates for the complete sample. Moreover, the 12CO J = 2–1 line has been used to determine the possible structures responsible for such profiles.
Results. We have classified the sources into four groups according to the different profiles and final gas expansion velocities. Type 1 and 2 profiles are broad and narrow symmetric lines, respectively. Furthermore, type 1 profiles are more related to previously studied, standard, spherically symmetric envelopes. Type 3 profiles on the contrary are strange profiles with very pronounced asymmetries. Finally, type 4 profiles are those showing two different components: a narrow line profile superimposed on a broad pedestal component. We find that for sources with this latter kind of profile, the variation amplitude is very low, which means that these SRs do not have a well-developed inner envelope differentiated from the outer one. Interestingly, we report a moderate correlation between mass-loss rates and 12CO J = 1–0/12CO J = 2–1 line intensity ratios for O-rich SRs, suggesting a different behaviour between C- and O-rich SRs. Using SHAPE+shapemol, we find a unified simple model based on an oblate spheroid placed in different orientations that may explain all the 12CO profiles in the sample, indicating that the gas expansion is in general predominantly equatorial. Moreover, in order to explain the type 4 profiles, we define an extra component which may somehow be a biconical structure or similar according to the structures already found in this kind of source. Type 1 and 2 profiles, curiously, may also be explained by standard spherically symmetric envelopes, but often requiring anomalously low velocities. Type 3 and 4 profiles however, need axial symmetry to be explained. We conclude that most circumstellar shells around SRs show axial, strongly nonspherical symmetry. More interferometric observations are needed in order to make firm conclusions about mass-loss processes and possible morphologies of SRs.
Akrolentiginöses Melanom unter der (Fehl-)Diagnose einer Onychomykose
Authors: Elsner P. , Meyer J. 
Published: July 2019

ZusammenfassungEin Patient wurde unter der Diagnose einer Paronychie und Onychomykose des Mittelfingers rechts ohne mykologischen Pilznachweis langfristig topisch und systemisch antimykotisch behandelt. Bei Therapieresistenz erfolgte nach Vorstellung bei einem anderen Hautarzt eine Hautbiopsie, die ein akrolentiginöses malignes Melanom ergab, das unter Teilamputation des Fingers operativ versorgt werden musste. Nach Facharztstandard war die Verzögerung der letztlich zielführenden Diagnostik als Behandlungsfehler zu bewerten. Unklare entzündliche Veränderungen oder Tumoren an den Akren sollten immer zur Differenzialdiagnose eines akrolentiginösen malignen Melanoms veranlassen, auch wenn prima vista viel häufigere Erkrankungen wie eine Onychomykose oder Verrucae vulgares wahrscheinlicher sind. Spätestens bei Nichtansprechen einer eingeleiteten Therapie sollte die Diagnose kritisch überprüft und ggf. eine dermatohistologische Befundsicherung durchgeführt werden.
Synthesis of Thioethers from Sulfonyl Chlorides, Sodium Sulfinates, and Sulfonyl Hydrazides
Authors: Wu Ronghai , Huang Keke , Qiu Guanyinsheng , Liu Jin-Biao 
Published: July 2019

Sulfur-containing moieties, especially thioethers (sulfides), play pivotal roles in the functionalities of many natural products, pharmaceutical compounds, and organic materials. In this review, we summarize the recent synthetic protocols of thioethers using thiolating reagents, including sulfonyl chlorides, sodium sulfinates, and sulfonyl hydrazides, as the ideal starting materials. Representative mechanisms for different types of reaction are also discussed.1 Introduction2 Synthesis of Thioethers from Sulfonyl Chlorides3 Synthesis of Thioethers from Sodium Sulfinates4 Synthesis of Thioethers from Sulfonyl Hydrazides5 Conclusion
Patella Height as Defined by Patella–Trochlear Articulation on MRI Scan—A Systemic Review of Current Evidence
Authors: Bajada Stefan , Mandalia Vipul 
Published: July 2019

AbstractThe objective of this study is to investigate what are the normal values, cutoff values, and optimal method of magnetic resonance imaging (MRI) scan for patella height focusing on patella–trochlear index (PTI). Electronic searches of MEDLINE (PubMed), Cumulative Index to Nursing and Allied Health Literature, Cochrane, Embase, ScienceDirect, and National Institute for Health and Care Excellence evidence up to April 2018 were completed. Eligibility criteria for selected studies included case-controlled studies, prospective cohort studies, cross-sectional and randomized controlled trials reporting on the use of MRI to evaluate direct patella height. Exclusions included animal or biomechanical/computational studies; interventional surgery such as knee arthroplasty, bracing, or realignment; and hereditary/congenital disease. A quality assessment of included studies was completed using the Methodological Index for Non-Randomized Studies (MINORS) Criteria. Sixty-four articles were identified which met the inclusion criteria. Following exclusions, 11 full-text studies were reviewed which reported direct measure of patella height. Nine studies reported the use of PTI. Two low power studies described PTI in normal healthy asymptomatic knee. Similarly, one study evaluated the effect of flexion and weight bearing on PTI values. The cutoff values varied between studies from <0.125 to <0.28 for patella alta and >0.50 to >0.80 for patella baja. This review found that currently, there are a very few studies on the assessment of PTI on MRI scan, with only two low powered studies on a true normal population. In view of this, there is a need for adequately powered studies to investigate patella height and PTI in asymptomatic healthy knees.
Can Revision TKA Patients Achieve Similar Clinical Functional Improvement Compared to Primaries?
Authors: Sachdeva Shikha , Baker James F. , Bauwens Jesse E. , Smith Langan S. , Sodhi Nipun , Mont Michael A. , Malkani Arthur L. 
Published: July 2019

AbstractThe etiology of failure following primary total knee arthroplasty (TKA) leading to revision surgery are multifactorial, including infection, instability, loosening, contracture, and wear. Although the majority of patients have successful outcomes following revision TKA, postoperative complications are still increased in these patients when compared to primary patients. For this reason, there has been a continued search to identify options, including prosthesis types, to potentially improve outcomes. Therefore, the purpose of this study was to determine if the clinical results achieved following revision TKA are comparatively similar to primaries using the same implant design. Specifically, we compared (1) Knee Society Functional and Range-of-Motion Knee Scores and (2) component survivorship. This was a retrospective analysis of 100 patients undergoing revision TKA due to an aseptic etiology, who were matched to a cohort of 100 patients who underwent primaries with the same prosthesis. There were no differences in the groups with respect to age at surgery, sex, and body mass index. The mean follow-up was 57 months in the revision group (range 24–105 months) and 67 months in the primary TKA group (range 55–123 months). American Knee Society Scores (KSS) and range of motion measurements recorded preoperatively and at the most recent postoperative visit were compared between both cohorts in order to compare postoperative outcomes. A p value of 0.05 was used for significance. The average improvement between the pre- and postoperative KSS function scores in both groups was similar, with both cohorts demonstrating a 28-point improvement. At 2-year follow-up, all-cause survivorship of the aseptic revision surgeries was 87%. Patients undergoing revision TKA for aseptic loosening can potentially expect similar improvements in clinical function scores and survivorship compared to primary TKA when controlling for implant type.
Understanding Clinical Inertia in Diabetes
Authors: Veettil Raveendran Arkiath 
Published: July 2019

AbstractClinical inertia is common in the management of asymptomatic chronic disease such as diabetes, hypertension, and dyslipidemia. In case of diabetes, it exists in all stages of management of diabetes. It can be at population level or at patient level. In addition to assessment of glycemic control with blood glucose and hemoglobin A1C (HbA1C) monitoring, emerging concepts such as “glycemic variability” and “time in range” are increasingly used. Inability to reduce “glycemic variability” and attain “time in range” targets also contributes to clinical inertia.
Memes and the media narrative
Authors: Wiggins Bradley E. 
Published: July 2019

Abstract
This article presents the results of a critical discourse analysis of internet memes. This analysis considers the highly visual nature of internet memes situated in a context of meme-as-utterance prompting other remixed versions as memes-as-responses. Prior to the analysis an orientation to pragmatics as related to internet memes is presented. Following this is an overview of memes research and a necessary discussion of the role of media narratives in the construction and dissemination of internet memes. Finally, a series of memes tweeted in response to Nike’s inclusion of former National Football League player, Colin Kaepernick, in its Just Do It anniversary campaign, serves as the corpus of analysis.
Development of graphene-chitosan composite modified screen-printed carbon electrode and its application for detection of rutin
Authors: Wahyuni W T , Arif Z , Maryam N S 
Published: July 2019

Abstract
Graphene is a prospective material for sensing devices due to its excellent electronic, thermal, and mechanical properties. In this study, low oxygen graphene was synthesized from graphite and nitronium ion using a microwave-assisted method. Graphene was dispersed into 0.05% chitosan solution and deposited by drop casting method on to screen-printed carbon electrode (SPCE) to form graphene-chitosan composite modified SPCE (SPCE-G-chit). The electrochemical performance of SPCE-G-chit was evaluated using flavonoid 3’,4’,5,7-tetrahydroxyflavone-3β-D-rutinoside (rutin). SPCE-G-chit provides linearity with R2
of 0.9944 for rutin measurement in the concentration range of 5× 10−7 to 1× 10−5 M. Meanwhile, the linearity of rutin at SPCE was lower (R2
0.9396). Limit of detection (LOD) and limit of quantitation (LOQ) of rutin measurement at SPCE-G-chit was lower (0.23 µM and 0.58 µM, respectively) compare to SPCE (LOD = 0.69 µM and LOQ = 1.75 µM, consecutively). The accuracy of rutin measurement at SPCE-G-chit was 99.45% while the accuracy of rutin measurement at SPCE was 72.18%. The result indicated that SPCE-G-chit provides superior analytical performance than SPCE and potential for electrochemical sensor development.
Optimation of Alkoxide formed step on Carboxymethyl Kappa Carrageenan synthesis
Authors: Kusumaningrum I K , Wijaya A R , Marfuah S , N Fadilah M 
Published: July 2019

Abstract
Carboxymethylation of kappa carrageenan with mono-chloroacetic acid as a reactant had been synthesized to produce carboxymethyl kappa carrageenan (CMKC). Carboxymethylation of kappa carrageenan was obtained in two steps. First, alkalization of k-carrageenan with NaOH to create alkoxy k-carrageenan, and optimization of the alkalization step, the optimization had been done include the mass ratio between NaOH and k-carrageenan and alkalization’s temperature, second, etherification of alkoxy k-carrageenan with Monochloroacetic acid (MCA) as etherification reactant, to produce CMKC. The optimal condition (2) characterization of the CMKC properties, including the degree of substitution (DS) and FTIR spectrum. The optimal condition was based on the formed degree of substitution(DS) of CMKC. The alkalization of k-carrageenan has been performed on three variations of mass ratio between NaOH: kappa carrageenan flour that dispersed in isopropanol, and then the mass ratio of NaOH: k-carrageenan that has the highest DS was used in the experiment to find the optimal alkalization temperature. To find the optimal temperature, the alkalization was performed at, 40°, 55° and 70°. The CMKC that has the highest DS value was produced when the mass ratio between NaOH mass: kappa carrageenan is 7,2:1, and the temperature of alkalization is 70°C, The DS value that reached when the CMKC synthesis had been done on the optimal alkalization condition is, 0,85.
The association of Cyp1A1 gene polymorphisms with Cyp1A1 enzymes, p53 protein, and vascular endothelial growth factor levels in pterygium
Authors: Hendriati  
Published: July 2019

Abstract
CYP1A1 gene, a carcinogenic metabolisms enzymes encoded gene, was previously found to be detected in pterygium tissue. We aimed to determine the association between CYP1A1m1 (rs4646903) polymorphisms with CYP1A1 enzymes, p53 protein, and vascular endothelial growth factor (VEGF) level in patients with inflammatory and non-inflammatory pterygium. DNA isolation was performed from a blood sample of 70 pterygium patients consisting of 35 inflammatory and 35 non-inflammatory pterygia. Rs 4646903 SNP Genotyping T> C (m1) in the CYP1A1 gene was performed using restriction fragment length polymorphisms-PCR (RFLP-PCR). PCR products confirmed and sent to Macrogen, South Korea for sequencing. Polymorphism results are characterized as wild type (TT), mutant homozygote (TC), and mutant heterozygote (CC). CYP1A1 gene polymorphisms consist of mutant heterozygote (TC), mutant homozygote (CC) and wild type (TT). In both groups, the heterozygote mutant was higher than the wild type and mutant homozygote. The CYP1A1 enzyme level was higher in inflammatory pterygium, P53 protein levels were higher in the non-inflammatory group, and VEGF levels were higher in the inflammatory group. CYP1A1 polymorphisms were not associated with CYP1A1 enzyme levels, p53 protein levels, and VEGF in both groups. CYP1A1 gene polymorphism has not been shown to be associated with levels of CYP1A1 enzymes, p53 and VEGF in both pterygium groups.
Population and activities of curculionids beetle in snake fruit (Salacca zalacca)
Authors: S Apriniarti M , Suryobroto B , Atmowidi T , Kahono S , Manalu W 
Published: July 2019

Abstract
Snake fruit (Salacca zalacca), an Indonesian native palm, has high economic value. This plant has a dioecious inflorescence. At the present time, pollination of snake fruit plants was still conducted by a human. Until now, some insect visitors as a pollinator of the plants were reported, such as stingless bees (Apidae) and curculionid beetles (Curculionidae). In this study, we study the population and activities of curculionid beetles in snake fruit plantations. Three plantations of snake fruit in Sumatera were used to observe beetle populations, i.e., Gunung Leuser National Park (Aceh), Padang Sidempuan (Medan), and Riak Siabun (Bengkulu). The sampling method was used to measure beetle populations by observed directly beetle population on the panicle (flowers). Observation of beetle activities was done by purposive sampling method in 08.00-12.00 am. Results showed that the highest beetle population (23096 individuals) occurred in Riak Siabun, Bengkulu. The highest visiting activity of beetle occurred in the morning.
Total phenolic content, total flavonoid content, and antioxidant activity of water and ethanol extract from Surian (Toona sinensis) leaves
Authors: Maulana T I , Falah S , Andrianto D 
Published: July 2019

Abstract
Surian (Toona sinensis) is a forest plant that is widespread in Asia. In Indonesia, this plant only used and known as a commodity for carpentry but in other nation, saurian is known as spices and traditional medicine because of its natural antioxidant potential. The objective of this study was assayed total phenolic content, total flavonoids content, and antioxidant activity from Surian leaves. Surian leaves were extracted by water and ethanol solvent. Water extraction was conducted by reflux in 90 °C then ethanol extraction was conducted by maceration, which is through various concentration 70%, 80%, 90%, and 96% of ethanol. Total phenolic content varied from 276.62 to 444.68 (mg GAE/g) and total flavonoid content ranged from 209.23 to 324.61 (mg QE/g). Antioxidant activity of the water and ethanol extracts was evaluated using DPPH (1,1-diphenyl-2-picryl-hydrazil) radical scavenging method. Total phenolic and flavonoid content of ethanol 90% extract and ethanol 96% extract had a higher amount than the other. The ethanol 96% extract had the strongest DPPH inhibition concentration 50% (IC50), which is 3.38 μg/mL while ascorbic acid is 3.90 μg/mL as a comparison. Antioxidant activity had a strong correlation with total flavonoid content.
Empowerment of women farmers on sustainable food Security with dynamics system modelling (in Nagari Koto Tuo, Harau Sub-district, Limapuluh Kota Regency, West Sumatera)
Authors: Ibrahim H , Yanti R 
Published: July 2019

Abstract
Based on Observation in Nagari Koto Tuo showed that empowerment of women farmer group in food security has not been optimal yet. The indicators are: 1) the education of respondents is dominated by the elementary school (42.17%), thus greatly affect to food pattern and serving meal menu; 2) land productivity less than 0.5 ha is 71% and depends on rainwater (68%), 3) family expenditure is allocated mostly for food with calorie consumption less than 2100 kilocalories (63.66 %) and, only 36.7 % is a requirement of nutritional adequacy and mostly nutritional status are not ideal. The descriptions are indicated that the role of Nagari institution with the support of local wisdom is not optimal. Consequently, the management of food security has not been sustainable. The purpose of this study is the creation of a dynamic system model of empowerment of women farmers through several interventions. The research method is surveyed with observation and interview. The system dynamics (2018-2028) model is simulated by increasing the synergy intervention of women empowerment function and Nagari institutional for Nagari women’s role (Bundo Kanduang). The intervention can be improved household welfare and can be reduced the poverty rate. The Implementation of the model is actualized by the empowerment of women farmers program according to carrying capacity environmental and local wisdom.