bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análise da influência de atributos fisiográficos e morfométricos na definição da suscetibilidade de bacias hidrográficas à ocorrência de corridas de massa
Authors: Cerri Rodrigo Irineu , Reis Fábio Augusto Gomes Vieira , Gramani Marcelo Fischer , Gabelini Beatriz Marques , Zaine José Eduardo , Sisto Felipe Pereira , Giordano Lucilia Do Carmo 
Published: March 2018

A Serra do Mar paulista, nos últimos 50 anos, passou por uma série de eventos pluviométricos intensos, que ocasionaram acidentes diversos relacionados a processos de dinâmica superficial, com consequências sociais, econômicas e ambientais catastróficas, principalmente nos municípios de Cubatão, São Sebastião e Caraguatatuba. Em 1967, ocorreu, entre Caraguatatuba e São Sebastião, um dos eventos mais excepcionais de escorregamentos generalizados associados a corridas já registrados no país. O objetivo do trabalho foi analisar atributos fisiográficos e morfométricos em relação à potencialidade de bacias hidrográficas à ocorrência de corridas de massa, na Serra do Mar do litoral norte do Estado de São Paulo. A área de estudo foi dividida em 13 unidades fisiográficas, abrangendo compartimentos de planícies; escarpas da Serra do Mar e espigões digitados; relevo de morros rebaixados e soerguidos pela Falha Camburu; relevos montanhosos e de morros com diferentes características no Planalto de Juqueriquerê; Planalto de Paraitinga na borda das escarpas da Serra do Mar; e morros, morrotes e colinas isoladas. Os resultados demonstraram que bacias hidrográficas localizadas em porções escarpadas, com alta declividade e forte estruturação das drenagens por fraturas/falhas, com vales encaixados, como a unidade fisiográfica II, apresentam maiores valores para os parâmetros morfométricos, indicando maior potencialidade à ocorrência de corridas. Portanto, a compartimentação fisiográfica e a análise dos parâmetros morfométricos possibilitaram a avaliação integrada de diferentes atributos do meio físico em relação à suscetibilidade de bacias hidrográficas à ocorrência de corridas, demonstrando que o controle estrutural na evolução geomorfológica dessas bacias é um fator fundamental tanto na distribuição de encostas com direções favoráveis à ocorrência de escorregamentos como nos resultados dos parâmetros morfométricos.
Granito Aragão — Suíte intrusiva Nhandú — um granito oxidado, tipo A2, de 1967 a 1964 Ma na Província Aurífera Alta Floresta — Cráton Amazônico
Authors: Dezula Samantha Evelyn Max , Barros Marcia Aparecida Sant’Ana , Pierosan Ronaldo , Santos João Orestes Schneider , Assis Rafael Rodrigues 
Published: March 2018

O Granito Aragão, localizado na Província Aurífera Alta Floresta (PAAF), consiste de um stock granítico de ~ 80 km2, de granulação média a grossa, textura porfirítica e composição modal monzogranítica a sienogranítica. Os dados geoquímicos indicam afinidade com magmas graníticos tipo-A2, similares àqueles gerados em margens continentais ativas evoluídas. As idades de cristalização U-Pb SHRIMP em zircão de 1964 ± 11 Ma e 1967 ± 2 Ma permitem incluí-lo na Suíte Intrusiva Nhandú (SINH) e correlacioná-lo com a Suíte Intrusiva Creporizão (SIC) na Província Mineral do Tapajós (PMT), no Pará. Associado ao Granito Aragão ocorre um megaenclave fanerítico médio a grosso, de textura porfirítica e composição modal granodiorítica a monzogranítica. O enclave apresenta padrão geoquímico semelhante a magmas graníticos shoshoníticos, e sua idade de cristalização U-Pb SHRIMP em zircão (1995 ± 5 Ma) indica relação com granitoides do Complexo Cuiú-Cuiú. O Granito Aragão ocorre alojado em granitoides foliados com idade de cristalização U-Pb SHRIMP de 2009 ± 4 Ma. Estes resultados sugerem que as rochas hospedeiras do Granito Aragão fazem parte do Complexo Cuiú-Cuiú. As correlações estratigráficas estabelecidas no presente trabalho indicam que a porção leste da PAAF representa a extensão da Província Tapajós-Parima, ao sul do Gráben do Cachimbo, norte do Estado de Mato Grosso.
Impaired Collateral Vessel Formation in Sickle Cell Disease
Authors: Okwan-Duodu Derick , Hansen Laura , Joseph Giji , Lyle Alicia N. , Weiss Daiana , Archer David R. , Taylor W. Robert 
Published: March 2018

Objective—
The adaptive response to vascular injury is the formation of functional collateral vessels to maintain organ integrity. Many of the clinical complications associated with sickle cell disease can be attributed to repeated bouts of vascular insufficiency, yet the detailed mechanisms of collateral vessel formation after injury are largely unknown in sickle cell disease. Here, we characterize postischemic neovascularization in sickle cell disease and the role of neutrophils in the production of reactive oxygen species.

Approach and Results—

We induced hindlimb ischemia by ligation of the femoral artery in Townes SS (sickle cell) mice compared with AA (wild type) mice. Perfusion recovery, ascertained using LASER (light amplification by stimulated emission of radiation) Doppler perfusion imaging, showed significant diminution in collateral vessel formation in SS mice after hindlimb ischemia (76±13% AA versus 34±10% in SS by day 28;
P
<0.001; n=10 per group). The incidence of amputation (25% versus 5%) and foot necrosis (80% versus 15%) after hindlimb ischemia was significantly increased in the SS mice. Motor function recovery evaluation by the running wheel assay was also impaired in SS mice (36% versus 97% at 28 days post-hindlimb ischemia;
P
<0.001). This phenotype was associated with persistent and excessive production of reactive oxygen species by neutrophils. Importantly, neutrophil depletion or treatment with the antioxidant N-acetylcysteine reduced oxidative stress and improved functional collateral formation in the SS mice.

Conclusions—
Our data suggest dysfunctional collateral vessel formation in SS mice after vascular injury and provide a mechanistic basis for the multiple vascular complications of sickle cell disease.
Electrocardiographic Repolarization Abnormalities and Electroanatomic Substrate in Arrhythmogenic Right Ventricular Cardiomyopathy
Authors: Kubala Maciej , Pathak Rajeev K. , Xie Shuanglun , Casado Arroyo Ruben , Tschabrunn Cory M. , Hayashi Tatsuya , Garcia Fermin C. , Supple Gregory E. , Santangeli Pasquale , Frankel David S. , Zado Erica S. , Callans David J. , Marchlinski Francis E. 
Published: March 2018

Background:
Repolarization abnormalities in arrhythmogenic right ventricular (RV) cardiomyopathy and their relationship to ventricular tachycardia substrate are incompletely understood.

Methods and Results:

In 40 patients (29 men, mean age 38 years) with arrhythmogenic RV cardiomyopathy, we compared the extent and location of abnormal T (NegT) waves ≥1 mm in depth (n=32) and downsloping elevated ST segment (n=13), in ≥2 adjacent leads, to area and location of endocardial bipolar (<1.5 mV) and unipolar (<5.5 mV) and epicardial bipolar (<1.0 mV) voltage abnormalities. Abnormal unipolar RV endocardial area of 33.4±19.3% was present in 8 patients without NegT waves. Patients with NegT waves extending beyond lead V
3
(n=20) had larger low bipolar (31.4±18.9% versus 16.5±14.6%;
P
=0.008) and unipolar endocardial areas (66.0±19.6% versus 47.4±25.1%;
P
=0.013) and larger epicardial low bipolar area (56.0±19.3% versus 40.1±24.9%;
P
=0.030) compared with those with NegT waves limited to leads V
1
through V
3
(n=20). ECG location of NegT waves regionalized to location of substrate. Patients with downsloping elevated ST segment, all localized to leads V
1
and V
2
, had more unipolar endocardial abnormalities (71.8±18.1% versus 49.4±23.5%;
P
=0.005) involving outflow and mid-RV, compared with patients without downsloping elevated ST segment.

Conclusions:

In arrhythmogenic RV cardiomyopathy, abnormal electroanatomic mapping areas are proportional to extent of T-wave inversion on 12-lead ECG. Marked voltage abnormalities can exist without repolarization change. Downsloping elevated ST-segment pattern in V
1
and V
2
occurs with more unipolar endocardial voltage abnormality, consistent with more advanced transmural disease.
Long-Term Outcome of Pulmonary Vein Isolation With and Without Focal Impulse and Rotor Modulation Mapping
Authors: Mohanty Sanghamitra , Mohanty Prasant , Trivedi Chintan , Gianni Carola , Della Rocca Domenico G. , Di Biase Luigi , Natale Andrea 
Published: March 2018

Background:
This meta-analysis systematically evaluated the outcome of pulmonary vein isolation (PVI) with and without focal impulse and rotor modulation (FIRM) ablation in patients with atrial fibrillation.

Methods and Results:

Extensive literature search was performed for studies reporting outcomes of PVI alone and PVI+FIRM procedures. For PVI alone, only randomized trials conducted in the past 3 years reporting single-procedure off-antiarrhythmic drugs success rate at ≥12-month follow-up were included. In PVI+FIRM group, all published studies reporting single-procedure off-antiarrhythmic drugs success rate with at least 1-year follow-up were identified. Meta-analytic estimates were derived using DerSimonian and Laird random-effects models, and pooled estimates of success rate (95% confidence interval) were computed. Statistical heterogeneity was assessed using Cochran
Q
test and
I
2
. Study quality was assessed using Newcastle–Ottawa Scale. Fifteen trials were included, 10 with PVI+FIRM (n=511, nonrandomized prospective design), and 5 with PVI-only trials (n=295, randomized trials). All patients in PVI-only trials had 100% nonparoxysmal atrial fibrillation, except 1 study, and no prior ablations. About 24% of PVI+FIRM population had paroxysmal atrial fibrillation. After 15.9±5.5 (median 12) months follow-up, the off-antiarrhythmic drugs pooled success rate was 50% in FIRM+PVI (95% confidence interval, 28%–72%) and 58% in PVI (95% confidence interval, 46%–71%). Difference in effect size between groups was not statistically significant (
P
=0.21). No significant heterogeneity (total or within group) was observed in this meta-analysis (negative
I
2
values considered equal to zero).

Conclusions:
The overall pooled estimate did not show any therapeutic benefit of PVI+FIRM approach over PVI alone, which suggests the need to reevaluate the clinical use of FIRM ablation in atrial fibrillation.
Downregulation of L‐Type Voltage‐Gated Ca
2+
, Voltage‐Gated K
+
, and Large‐Conductance Ca
2+
‐Activated K
+
Channels in Vascular Myocytes From Salt‐Loading Offspring Rats Exposed to Prenatal Hypoxia
Authors: Liu Bailin , Shi Ruixiu , Li Xiang , Liu Yanping , Feng Xueqin , Chen Xueyi , Fan Xiaorong , Zhang Yingying , Zhang Wenna , Tang Jiaqi , Zhou Xiuwen , Li Na , Lu Xiyuan , Xu Zhice 
Published: March 2018

Background
Prenatal hypoxia is suggested to be associated with increased risks of hypertension in offspring. This study tested whether prenatal hypoxia resulted in salt‐sensitive offspring and its related mechanisms of vascular ion channel remodeling.

Methods and Results

Pregnant rats were housed in a normoxic (21% O
2
) or hypoxic (10.5% O
2
) chamber from gestation days 5 to 21. A subset of male offspring received a high‐salt diet (8% NaCl) from 4 to 12 weeks after birth. Blood pressure was significantly increased only in the salt‐loading offspring exposed to prenatal hypoxia, not in the offspring that received regular diets and in control offspring provided with high‐salt diets. In mesenteric artery myocytes from the salt‐loading offspring with prenatal hypoxia, depolarized resting membrane potential was associated with decreased density of L‐type voltage‐gated Ca
2+
(Cav1.2) and voltage‐gated K
+
channel currents and decreased calcium sensitive to the large‐conductance Ca
2+
‐activated K
+
channels. Protein expression of the L‐type voltage‐gated Ca
2+
α1C subunit, large‐conductance calcium‐activated K
+
channel (β1, not α subunits), and voltage‐gated K
+
channel (

K
V

2.1, not

K
V

1.5 subunits) was also decreased in the arteries of salt‐loading offspring with prenatal hypoxia.

Conclusions
The results demonstrated that chronic prenatal hypoxia may program salt‐sensitive hypertension in male offspring, providing new information of ion channel remodeling in hypertensive myocytes. This information paves the way for early prevention and treatments of salt‐induced hypertension related to developmental problems in fetal origins.
A Moist Static Energy Framework for Zonal-Mean Storm-Track Intensity
Authors: Shaw Tiffany A. , Barpanda Pragallva , Donohoe Aaron 
Published: March 2018

Abstract
A moist static energy (MSE) framework for zonal-mean storm-track intensity, defined as the extremum of zonal-mean transient eddy MSE flux, is derived and applied across a range of time scales. According to the framework, storm-track intensity can be decomposed into contributions from net energy input [sum of shortwave absorption and surface heat fluxes into the atmosphere minus outgoing longwave radiation (OLR) and atmospheric storage] integrated poleward of the storm-track position and MSE flux by the mean meridional circulation or stationary eddies at the storm-track position. The framework predicts storm-track decay in spring and amplification in fall in response to seasonal insolation. When applied diagnostically the framework shows shortwave absorption and land turbulent surface heat fluxes account for the seasonal evolution of Northern Hemisphere (NH) intensity; however, they are partially compensated by OLR (Planck feedback) and stationary eddy MSE flux. The negligible amplitude of Southern Hemisphere (SH) seasonal intensity is consistent with the compensation of shortwave absorption by OLR and oceanic turbulent surface heat fluxes (ocean energy storage). On interannual time scales, El Niño minus La Niña conditions amplify the NH storm track, consistent with decreased subtropical stationary eddy MSE flux. Finally, on centennial time scales, the CO2 indirect effect (sea surface temperature warming) amplifies the NH summertime storm track whereas the direct effect (increased CO2 over land) weakens it, consistent with opposing turbulent surface heat flux responses over land and ocean.
Cross-Basin Decadal Climate Regime Connecting the Colorado River with the Great Salt Lake
Authors: Simon Wang S.-Y. , Gillies Robert R. , Chung Oi-Yu , Shen Chaopeng 
Published: March 2018

Abstract
The 2013 federal Colorado River Basin Water Supply and Demand Study projected the water imbalance between future supply and demand to increase. The Colorado water supply (WS) exemplifies a pronounced quasi-decadal oscillation (QDO) of 10–20 years throughout its historical record; however, this QDO feature is unaccounted for in the climate models used to project the future WS. Adjacent to the Colorado River, the large watershed of the Great Salt Lake (GSL) in Utah records the hydrologic QDO signal in its water surface, leading previous studies to explore the cause of decadal fluctuations in the lake elevation and assess predictability. This study reports a remarkable coherence between the Colorado WS and the GSL elevation at the 10–20-yr time scale. Analysis of precipitation and terrestrial water storage anomalies suggests a cross-basin connection in the climate and hydrometeorological variations of the Colorado WS and the GSL. The 160-yr-long and well-kept GSL elevation record makes it an effective indicator for the Colorado WS.
Carbon monoxide inhalation induces headache but no migraine in patients with migraine without aura
Authors: Ghanizada Hashmat , Arngrim Nanna , Schytz Henrik Winther , Olesen Jes , Ashina Messoud 
Published: March 2018

Introduction Carbon monoxide is an endogenously produced signaling gasotransmitter known to cause headache and vasodilation. We hypothesized that inhalation of carbon monoxide would induce migraine-like attacks in migraine without aura patients. Methods In a randomized, double-blind, placebo-controlled crossover design, 12 migraine patients were allocated to inhalation of carbon monoxide (carboxyhemoglobin 22%) or placebo on two separate days. Headache and migraine characteristics were recorded during hospital (0–2 hours) and post-hospital (2–13 hours) phases. Results Six patients (50%) developed migraine-like attacks after carbon monoxide compared to two after placebo (16.7%) ( p = 0.289). The median time to onset of migraine-like attacks after carbon monoxide inhalation was 7.5 h (range 3–12) compared to 11.5 h (range 11–12) after placebo. Nine out of 12 patients (75%) developed prolonged headache after carbon monoxide. The area under the curve for headache score (0–13 hours) was increased after carbon monoxide compared with placebo ( p = 0.033). Conclusion Carbon monoxide inhalation did not provoke more migraine-like attacks in migraine patients compared to placebo, but induced more headache in patients compared to placebo. These data suggest that non-toxic concentrations of carbon monoxide had low potency in migraine induction and that the carbon monoxide inhalation model is not suitable to study migraine.
Subacromial Decompression Yields a Better Clinical Outcome Than Therapy Alone: A Prospective Randomized Study of Patients With a Minimum 10-Year Follow-up
Authors: Farfaras Stefanos , Sernert Ninni , Rostgard Christensen Lars , Hallström Erling K. , Kartus Jüri-Toomas 
Published: March 2018

Background: The long-term outcome after the treatment of subacromial impingement syndrome (SAIS) with either nonsurgical or surgical methods has not been thoroughly investigated. Hypothesis/Purpose: The purpose was to evaluate the long-term clinical outcome and the presence of rotator cuff injuries and osteoarthritis (OA) after the surgical and nonsurgical treatment of SAIS. The hypothesis was that, at a minimum 10 years after the initial treatment, patients who had undergone acromioplasty would have a better clinical outcome and run a lower risk of developing rotator cuff ruptures and OA as compared with those treated with physical therapy. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: Eighty-seven patients with SAIS were randomized to 3 groups: open acromioplasty (open surgery group [OSG]), arthroscopic acromioplasty (arthroscopic surgery group [ASG]), and nonsurgical treatment (physical therapy group [PTG]). The Constant score, the Watson and Sonnabend score, and the 36-Item Short Form Health Survey (SF-36) questionnaire were used as outcome measurements. Furthermore, bilateral ultrasound examinations were performed to detect rotator cuff ruptures and bilateral radiographs to detect OA. Sixty-six patients (76%) attended the clinical follow-up at least 10 years after the initial treatment. Results: The groups were demographically comparable at baseline. The Constant score improved significantly at follow-up for the OSG ( P = .003) and ASG ( P = .011), while no significant improvement was detected for the PTG. The OSG revealed a significant improvement versus the PTG at follow-up ( P = .011); otherwise, no significant differences were found. For the Watson and Sonnabend score, the OSG revealed a significant improvement in 13 of 14 questions. The corresponding finding was made for the ASG and PTG in 9 of 14 questions ( P = .14). According to ultrasound, 1 of 20 patients in the OSG had a full-thickness rotator cuff rupture on the index side. The corresponding finding was made for 1 of 18 patients in the ASG and 4 of 28 in the PTG ( P = .29). Per the radiographs, 3 of 20 patients in the OSG had moderate or severe OA in the index shoulder. The corresponding finding was made for 1 of 18 patients in the ASG and 0 of 28 in the PTG ( P = .12). Conclusion: After a minimum 10 years of follow-up, the surgical treatment of SAIS appears to render better clinical results than physical therapy alone. No significant differences were found among the groups in terms of the presence of full-thickness rotator cuff ruptures and OA.
Effect of Predraft Ulnar Collateral Ligament Reconstruction on Future Performance in Professional Baseball: A Matched Cohort Comparison
Authors: Camp Christopher L. , Conte Stan , D’Angelo John , Fealy Stephen A. , Ahmad Christopher S. 
Published: March 2018

Background: In recent years, there has been a dramatic rise in the annual number of ulnar collateral ligament (UCL) reconstructions performed in amateur baseball pitchers. Accordingly, increasing numbers of players are entering professional baseball having already undergone the procedure; however, the effect of prior UCL reconstruction on future success remains unknown. Purpose: (1) To provide an epidemiologic report on baseball players who undergo UCL reconstruction before being selected in the Major League Baseball (MLB) Draft, (2) to define the outcomes in terms of statistical performance, and (3) to compare these results with those of matched controls (ie, non–UCL reconstruction). Study Design: Cohort study; Level of evidence, 3. Methods: The MLB Amateur Draft Database was queried to identify all drafted pitchers who underwent UCL reconstruction before being drafted. For each pitcher drafted from 2005 to 2014 with prior UCL reconstruction, 3 healthy controls with no history of elbow surgery were randomly identified for matched analysis. A number of demographic and performance comparisons were made between these groups. Results: A total of 345 pitchers met inclusion criteria. The annual number of pitchers undergoing predraft UCL reconstructions rose steadily from 2005 to 2016 ( P < .001). For matched control analysis, 252 pitchers with a UCL reconstruction and a minimum 2-year follow-up (drafted between 2005 and 2014) were matched to 756 controls (non–UCL reconstruction). As compared with the non–UCL reconstruction group, pitchers who underwent predraft UCL reconstruction reached the MLB level with greater frequency (20% vs 12%, P = .003), and their MLB statistical performances were similar for all measures. Compared with all other pitchers drafted during that period, players who had a predraft UCL reconstruction demonstrated an increased likelihood of reaching progressive levels of play (Full Season A, AA, and MLB) within a given time frame ( P < .05 for all). Conclusion: The number of UCL reconstructions performed in amateur baseball players before the draft increased year over year for the entire study period. Professional pitchers who underwent UCL reconstruction as amateurs appear to perform at least as well as, if not better than, matched controls without elbow surgery.
Luminex® xMAP® technology is an effective strategy for high-definition human leukocyte antigen typing of cord blood units prior to listing
Authors: Guarene Marco , Badulli Carla , Cremaschi Anna L , Sbarsi Ilaria , Cacciatore Rosalia , Tinelli Carmine , Pasi Annamaria , Bergamaschi Paola , Perotti Cesare G 
Published: March 2018

Introduction: Allele-level donor–recipient match at HLA-A, HLA-B, HLA-C and HLA-DRB1 loci impacts the outcome after cord blood transplantation for hematologic malignancies and modifies the strategy of donor selection. High definition of both class I and II HLA loci at time of listing is a way to improve the attractiveness of cord blood bank inventories, reducing the time for donor search and procurement and simplifying donor choice, in particular, for patients of non-European heritage. Methods: In 2014, Luminex® xMAP® technology was introduced in our laboratory practice and was applied to cord blood units typing. In this study, we evaluated the impact of this strategy in comparison with the platform in use until 2013, relying on LiPA reverse polymerase chain reaction–sequence-specific oligonucleotide (revPCR-SSO) plus polymerase chain reaction–sequence-specific primer (PCR-SSP). Results: In 2014, the time for testing was shorter (141 vs 181 days on average), the number of test repetitions was lower (in particular for HLA-A locus, p = 0.026), and the cost reduced (240.7 vs 395.6 euros per unit on average) compared to 2013, demonstrating that Luminex xMAP technology is superior to the previous approach. Conclusion: Luminex xMAP platform has useful application in cord blood banking programs, to achieve high-definition HLA typing of cord blood units at the time of banking in a quick, accurate, and cost-effective manner.