bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thromboembolism in acute lymphoblastic leukemia: results of NOPHO ALL2008 protocol treatment in patients aged 1 to 45 years
Authors: Rank Cecilie Utke , Toft Nina , Tuckuviene Ruta , Grell Kathrine , Nielsen Ove Juul , Frandsen Thomas Leth , Marquart Hanne Vibeke Hansen , Albertsen Birgitte Klug , Tedgård Ulf , Hallböök Helene , Ruud Ellen , Jarvis Kirsten Brunsvig , Quist-Paulsen Petter , Huttunen Pasi , Wartiovaara-Kautto Ulla , Jónsson Ólafur Gísli , Trakymiene Sonata Saulyte , Griškevičius Laimonas , Saks Kadri , Punab Mari , Schmiegelow Kjeld 
Published: April 2018

Abstract
Thromboembolism frequently occurs during acute lymphoblastic leukemia (ALL) therapy. We prospectively registered thromboembolic events during the treatment of 1772 consecutive Nordic/Baltic patients with ALL aged 1 to 45 years who were treated according to the Nordic Society of Pediatric Hematology and Oncology ALL2008 protocol (July 2008-April 2017). The 2.5-year cumulative incidence of thromboembolism (N = 137) was 7.9% (95% confidence interval [CI], 6.6-9.1); it was higher in patients aged at least 10 years (P &lt; .0001). Adjusted hazard ratios (HRas) were associated with greater age (range, 10.0-17.9 years: HRa, 4.9 [95% CI, 3.1-7.8; P &lt; .0001]; 18.0-45.9 years: HRa, 6.06 [95% CI, 3.65-10.1; P &lt; .0001]) and mediastinal mass at ALL diagnosis (HRa, 2.1; 95% CI, 1.0-4.3; P = .04). In a multiple absolute risk regression model addressing 3 thromboembolism risk factors, age at least 10 years had the largest absolute risk ratio (RRage, 4.7 [95% CI, 3.1-7.1]; RRenlarged lymph nodes, 2.0 [95% CI, 1.2-3.1]; RRmediastinal mass, 1.6 [95% CI, 1.0-2.6]). Patients aged 18.0 to 45.9 years had an increased hazard of pulmonary embolism (HRa, 11.6; 95% CI, 4.02-33.7; P &lt; .0001), and patients aged 10.0 to 17.9 years had an increased hazard of cerebral sinus venous thrombosis (HRa, 3.3; 95% CI, 1.5-7.3; P = .003) compared with children younger than 10.0 years. Asparaginase was truncated in 38/128 patients with thromboembolism, whereas thromboembolism diagnosis was unassociated with increased hazard of relapse (P = .6). Five deaths were attributable to thromboembolism, and patients younger than 18.0 years with thromboembolism had increased hazard of dying compared with same-aged patients without thromboembolism (both P ≤ .01). In conclusion, patients aged at least 10 years could be candidates for preemptive antithrombotic prophylaxis. However, the predictive value of age 10 years or older, enlarged lymph nodes, and mediastinal mass remain to be validated in another cohort.
Global optimization strategies for implementing 3D common-reflection-surface stack using the very fast simulated annealing algorithm: Application to real land data
Authors: Garabito German 
Published: April 2018

The 3D common-reflection-surface (CRS) stack operator depends on eight kinematic wavefield attributes that must be extracted from the prestack data. These attributes are obtained by an efficient optimization strategy based on the maximization of the coherence measure of the seismic reflection events included by the CRS stacking operator. The main application of these kinematic attributes is to simulate zero-offset stacked data; however, they can also be used for regularization of the prestack data, prestack migration, and velocity model determination. The initial implementations of the 3D CRS stack used grid-search techniques to determine the attributes in several steps with the drawback that accumulated errors can deteriorate the final result. In this work, the global optimization very fast simulated annealing algorithm is used to search for the kinematic attributes by applying three optimization strategies for implementing CRS stacking: (1) simultaneous global search of five kinematic attributes of the 3D common-diffraction-surface stacking operator, (2) two-step global optimization strategy to first search for three attributes and then five attributes of the CRS stacking operator, and (3) simultaneous global search of eight kinematic attributes of the CRS operator. The proposed CRS stacking algorithms are applied to land data of the Potiguar Basin, Brazil. It is demonstrated that the one-step optimization strategy of the eight parameters produces the best results, however, with a higher computational cost.
Cost-Effectiveness Analyses of the 21-Gene Assay in Breast Cancer: Systematic Review and Critical Appraisal
Authors: Wang Shi-Yi , Dang Weixiong , Richman Ilana , Mougalian Sarah S. , Evans Suzanne B. , Gross Cary P. 
Published: April 2018

Purpose Prior studies examining cost effectiveness of the 21-gene assay (Oncotype DX [ODX]) for women with hormone receptor–positive, early-stage breast cancer have yielded disparate results. We aimed to explore why these analyses may have yielded different conclusions. Methods We conducted a systematic literature review of cost-effectiveness analyses (CEAs) of ODX. We examined the extent to which the structure of CEA modeling, the assumptions of the models, and the selection of input parameters influenced cost-effectiveness estimates. We also explored the prevalence of industry funding and whether industry funding was associated with study designs favoring ODX. Results We identified 27 analyses, 15 of which received industry funding. In 18 studies, the clinical characteristics (eg, tumor size and grade) commonly used to make chemotherapy decisions were not incorporated into simulation modeling; thus, these studies would favor ODX being cost effective and might not reflect clinical practice. Most studies ignored the heterogeneous effect of ODX on chemotherapy use; only five studies assumed that ODX would increase chemotherapy use for clinically low-risk patients but decrease chemotherapy use for clinically high-risk patients. No study used population-based joint distributions of ODX recurrence score and tumor characteristics, and 12 studies inappropriately assumed that chemotherapy would increase distant recurrence for the low recurrence score group; both approaches overestimated the benefits of ODX. Industry-funded studies tended to favor ODX; all five studies that reported ODX as being cost saving were industry funded. In contrast, two studies that reported an incremental cost-effectiveness ratio > $50,000 per quality-adjusted life-year were not funded by industry. Conclusion Although a majority of published analyses indicated that ODX is cost effective, they incorporated study designs that can increase the risk of bias.
Treatment of Stage IV Favorable Histology Wilms Tumor With Lung Metastases: A Report From the Children’s Oncology Group AREN0533 Study
Authors: Dix David B. , Seibel Nita L. , Chi Yueh-Yun , Khanna Geetika , Gratias Eric , Anderson James R. , Mullen Elizabeth A. , Geller James I. , Kalapurakal John A. , Paulino Arnold C. , Perlman Elizabeth J. , Ehrlich Peter F. , Malogolowkin Marcio , Gastier-Foster Julie M. , Wagner Elizabeth , Grundy Paul E. , Fernandez Conrad V. , Dome Jeffrey S. 
Published: April 2018

Purpose The National Wilms Tumor Study (NWTS) treatment of favorable histology Wilms tumor with lung metastases was vincristine/dactinomycin/doxorubicin (DD4A) and lung radiation therapy (RT). The AREN0533 study applied a new risk stratification and treatment strategy to improve event-free survival (EFS) while reducing exposure to lung RT. Methods Patients with favorable histology Wilms tumor and isolated lung metastases showing complete lung nodule response (CR) after 6 weeks of DD4A continued receiving chemotherapy without lung RT. Patients with incomplete response (IR) or loss of heterozygosity at chromosomes 1p/16q received lung RT and four cycles of cyclophosphamide/etoposide in addition to DD4A drugs (Regimen M). AREN0533 was designed to preserve a 4-year EFS of 85% for lung nodule CR and improve 4-year EFS from 75% to 85% for lung nodule IR. Results Among 292 assessable patients, 133 had CR and 159 had IR. For patients with CR, 4-year EFS and overall survival (OS) estimates were 79.5% (95% CI, 71.2% to 87.8%) and 96.1% (95% CI, 92.1% to 100%), respectively. Expected versus observed event rates were 15% and 20.2% ( P = .052), respectively. For patients with IR, 4-year EFS and OS estimates were 88.5% (95% CI, 81.8% to 95.3%) and 95.4% (95% CI, 90.9% to 99.8%), respectively. Expected versus observed event rates were 25% and 12.2% ( P < .001), respectively. Overall, 4-year EFS and OS were 85.4% (95% CI, 80.5% to 90.2%) and 95.6% (95% CI, 92.8% to 98.4%) compared with 72.5% (95% CI, 66.9% to 78.1%; P < .001) and 84.0% (95% CI, 79.4% to 88.6%; P < .001), respectively, in the predecessor NWTS-5 study. Conclusion Excellent OS was achieved after omission of primary lung RT in patients with lung nodule CR, although there were more events than expected. EFS was significantly improved, with excellent OS, in patients with lung nodule IR using four cycles of cyclophosphamide/etoposide in addition to DD4A drugs. The overall AREN0533 treatment strategy yielded EFS and OS estimates that were superior to previous studies.
Returning Individual Genetic Research Results to Research Participants: Uptake and Outcomes Among Patients With Breast Cancer
Authors: Bradbury Angela R. , Patrick-Miller Linda , Egleston Brian L. , Maxwell Kara N. , DiGiovanni Laura , Brower Jamie , Fetzer Dominique , Gaieski Jill Bennett , Brandt Amanda , McKenna Danielle , Long Jessica , Powers Jacquelyn , Stopfer Jill E. , Nathanson Katherine L. , Domchek Susan M. 
Published: April 2018

PurposeUnderstanding the outcomes of returning individual genetic research results to participants is critical because some genetic variants are found to be associated with health outcomes and have become available for clinical testing.Materials and MethodsBRCA1/2-negative women with early-onset breast cancer, multiple primary cancers, or a family history of breast cancer who participated in a gene discovery cancer registry were offered the opportunity to learn their individual genetic research results of 24 breast cancer susceptibility genes with a genetic counselor after predisclosure genetic counseling. Outcomes included uptake of research results, knowledge, informed choice, psychosocial adjustment, uncertainty, satisfaction, and uptake of clinical confirmation testing.ResultsFour hundred two potential participants were contacted. One hundred ninety-four participants (48%) did not respond despite multiple attempts, and 85 participants (21%) actively or passively declined. One hundred seven participants (27%) elected for predisclosure counseling and were more likely to be younger, married, and white. Ninety percent of participants who had predisclosure counseling elected to receive their genetic research results, and 89% made an informed choice. Knowledge increased significantly after predisclosure counseling, and anxiety, intrusive cancer-specific distress, uncertainty, and depression declined significantly after receipt of results. General anxiety and intrusive cancer-specific distress declined significantly for both participants with a positive result and those with a negative result. Sixty-four percent of participants had clinical confirmation testing when recommended, including all participants with a mutation in a high-penetrance gene.ConclusionUptake of genetic research results may be lower than anticipated by hypothetical reports and small select studies. Participants who elected to receive research results with genetic providers did not experience increases in distress or uncertainty, but not all patients return for confirmation testing.
Older Subjects With β-Cell Dysfunction Have an Accentuated Incretin Release
Authors: de Jesús Garduno-Garcia José , Gastaldelli Amalia , DeFronzo Ralph A , Lertwattanarak Raweewan , Holst Jens J , Musi Nicolas 
Published: April 2018

Abstract

Objective
Insulin secretion (IS) declines with age, which increases the risk of impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) in older adults. IS is regulated by the incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). Here we tested the hypotheses that incretin release is lower in older adults and that this decline is associated with β-cell dysfunction.

Research Design
A total of 40 young (25 ± 3 years) and 53 older (74 ± 7 years) lean nondiabetic subjects underwent a 2-hour oral glucose tolerance test (OGTT). Based on the OGTT, subjects were divided into three groups: young subjects with normal glucose tolerance (Y-NGT; n = 40), older subjects with normal glucose tolerance (O-NGT; n = 32), and older subjects with IGT (O-IGT; n = 21).

Main Outcome Measures
Plasma insulin, C-peptide, GLP-1, and GIP concentrations were measured every 15 to 30 minutes. We quantitated insulin sensitivity (Matsuda index) and insulin secretory rate (ISR) by deconvolution of C-peptide with the calculation of β-cell glucose sensitivity.

Results
Matsuda index, early phase ISR (0 to 30 minutes), and parameters of β-cell function were lower in O-IGT than in Y-NGT subjects but not in O-NGT subjects. GLP-1 concentrations were elevated in both older groups [GLP-1 area under the curve (AUC)0–120 was 2.8 ± 0.1 in Y-NGT, 3.8 ± 0.5 in O-NGT, and 3.7 ± 0.4 nmol/L∙120 minutes in O-IGT subjects; P < 0.05], whereas GIP secretion was higher in O-NGT than in Y-NGT subjects (GIP AUC0–120 was 4.7 ± 0.3 in Y-NGT, 6.0 ± 0.4 in O-NGT, and 4.8 ± 0.3 nmol/L∙120 minutes in O-IGT subjects; P < 0.05).

Conclusions
Aging is associated with an exaggerated GLP-1 secretory response. However, it was not sufficient to increase insulin first-phase release in O-IGT and overcome insulin resistance.
Przysłowie jako jednostka języka (w perspektywie tekstologii integralnej)
Authors: Wasiuta Sebastian 
Published: April 2018

Proverb as a linguistic unit (from the perspective of integral text linguistics)
The paper presents arguments in favour of treating proverbs as text, and in consequence, as linguistic units. The starting point is the concept of integral text linguistics formulated by Jerzy Bartmiński and Stanisława Niebrzegowska-Bartmińska in their handbook Tekstologia (‘Text linguistics’, 2009). According to this theory, text is a supra-sentence linguistic unit, and the text of the parole plane corresponds to an abstract template of the langue plane. The argumentation that this paper presents in favour of regarding proverbs as text is based on an analysis of examples from the National Corpus of Polish which contain proverbs. It shows clearly that proverbs fulfill all of the requirements of textuality; among others, they are uniquely distinguished as a communicative whole, they receive a clear genre qualification, they have their senders and receivers, a clear communicative intent and a stylistic qualifier. The final part of the paper contains a proposition to describe proverbs as “minimal text”, and to separate the terms minimal text and prototypical text. Within this interpretation, a proverb is a prototypical minimal text that is different from both non-prototypical minimal texts, and from non-prototypical non-minimal long texts such as novels, as well as prototypical texts such as fables which tend to be longer (non-minimal).
Cechy słowotwórcze czasowników oznaczających zmianę pozycji ciała względem osi ciała
Authors: Witkowska Paulina 
Published: April 2018

Word-formational features of verbs denoting change of position with respect to the axis of the body
The paper presents word-derivational features of verbs which co-occur with się and denote a change in the position of the body with respect to its vertical axis. The analysis shows how differences in the morphological structure of these verbs influence the manner in which the change of the position of the body proceeds. Moreover, the paper shows which elements of the meanings of verbs are carried by prefixes with which these verbs combine. The article also shows which of the morphological forms of the analysed verbs are primary, and what derivational relations hold between them and their derivatives.
Gatunkowe uwarunkowania znaczeń symbolicznych
Authors: Niebrzegowska-Bartmińska Stanisława 
Published: April 2018

Genre conditioning of symbolic meanings
Folklore texts operate on two levels: inside the folk culture in combination with traditional beliefs and customs, and within the national culture as a point of reference and source of inspiration for writers and poets. Individual words also function on those two levels, as they can be understood ‘the literary way’ or ‘the folk way’. The paper presents two units of the vocabulary of the national language (jabłoń ‘apple tree’ and jabłko ‘apple’) which have fixed base meanings but which also accommodate additional senses on a higher semantic level and thus become the signifiant for a new sign. In folklore texts, depending on the genre, the images of apple tree and apple accept the symbolic senses of happy and fulfilled love (in love and courting songs), fertility and vitality (in wedding songs), of readiness for marriage and the stable, cosmic order (in wishing carols), of temptation and sin (in nativity plays), richness and ability to regenerate and renew life (in fairy tales), of the sense of security and parental care (in orphan songs), of the value of family home and proximity to the loved ones (in soldiers’ songs). These symbols can be explained using extralinguistic data (beliefs and customs) as the same senses can be expressed through words, rituals, or objects. The analysis reveals that the images of apple tree and apple serve to communicate values underlying the image of the world contained within the specific genre. The same images, transplanted to a different domain, outside of their particular social group, lose their value, become illegible, incomprehensible, and are viewed as merely a signal of folksiness.
Język jako wartość w „Tygodniku Ilustrowanym” w latach 1918–1928
Authors: Gabryś-Sławińska Monika 
Published: April 2018

Language as a value in ”Tygodnik Ilustrowany” in the years 1918–28
In the years 1918–28, “Tygodnik Ilustrowany” offered its readers a new outlook on the issues of language and linguistics. Resigning from treating Polish as an argument in the struggle for national values, in the years 1920–25, the journal tried to present language as a value in its own right. In this period, it published the works of specialists such as Kryński and Lange. After a period of interest in the specificity of language, its secrets and mechanisms, one can observe a return to the instrumental treatment of Polish. Fixed in the journal’s tradition, the vision of language as subordinate to the fulfillment of specific goals reappears in the years 1926–28.
DE QUE FAMÍLIA ESTAMOS FALANDO? ENTRE O IDEAL E O VIVIDO
Authors: Nascimento Ivany Pinto 
Published: April 2018

O presente texto surgiu a partir de estudos e pesquisas bibliográficas desenvolvidas com a juventude e sua interface com a educação. Nesta investida abordamos a temática família e sua relação com a tradição na perspectiva do ideal e com o vivido na perspectiva das famílias reconstituídas. Estas últimas são, na contemporaneidade, representativas da constituição das famílias brasileiras. Para tanto, organizamos a abordagem desta temática a partir dos seguintes tópicos: 1) (Re) avivando os fios condutores do processo de mudanças no ideário da família; 2) Entre o ideal e o vivido: o que quer a família?; 3) Entre os amores e os (des) amores segue a família do século XXI; 4) O Contexto do Neoliberalismo enlaçado na família: Qual a saída?; 5) As juventudes e suas famílias; 6) Amarrando alguns pontos sobre o processo de trabalho com grupos familiares.
ESPAÇOS E TEMPOS ESCOLARES CONTEMPORÂNEOS: ESPAÇOS E TEMPOS DE EXCLUSÃO?
Authors: Severo Rita Basso 
Published: April 2018

Resumo: Este texto é um recorte de uma pesquisa realizada com jovens-alunos em duas escolas públicas de Porto Alegre. Tem como intenção refletir sobre a seguinte questão: o que faz a escola com aqueles que não conseguem alinhar seus tempos de vida com o rigoroso tempo escolar? Operei com um referencial teórico que nos permite pensar as juventudes em uma dimensão mais ampla do que a simples idade cronológica, assim, cabe considerar que a condição de ‘ser jovem’ na contemporaneidade não deve ser pensada fora do contexto histórico, social e cultural. Com ancoragem na etnografia pós-moderna as ferramentas teórico-metodológicas utilizadas foram conversas e entrevistas advindas dos diários de campo. Os achados me conduziram a pensar que as práticas destes jovens escapam a algumas formas de captura, inquietam a segurança dos saberes escolares, e questionam o poder de nossas práticas criando fendas nas instituições escolares. Palavras-chave: Escola. Juventudes. Espaços. Tempos. Exclusão
IDENTIFICAÇÃO PROJETIVA: DO ATAQUE A EMPATIA
Authors: Clarke Simon 
Published: April 2018

ldentificação Projetiva e um dos conceitos centrais na teoria psicanalitica Kleiniana. Este artigo procura dar uma visão geral do conceito, seus usos e diferentes interpretações, além de colocá-lo em um contexto que possa ser util para aqueles envolvidos em estudos psico-sociais e psicanaliticos. Ele aborda alguns dos principais argumentos e controvérsias que giram em torno do conceito e das tentativas de simplificar a idéia, sugerindo quão valiosa ferramenta o conceito pode ter na investigação da psicodinâmica do mundo social.
ESPORTE E INDÚSTRIA CULTURAL EM THEODOR W. ADORNO: REFLEXÕES SOBRE A EDUCAÇÃO DO CORPO
Authors: Vaz Alexandre Fernandez 
Published: April 2018

é nos marcos da industria cultural que se estrutura boa parte das práticas pedagógicas contemporâneas. Nao é diferente quando com a educação do corpo, em especial com uma de suas mais marcantes formas, o esporte. O objetivo do presente trabalho é apresentar e discutir alguns fragmentos da obra de Theodor W. Adorno, em parceria com Max Horkheimer ou não, que tratam dessa temática. Tomando como ponto de partida a tecnologização do corpo, procura-se pensar os caminhos que são indicados para a reflexão de uma pedagogia do corpo na contemporaneidade. Nesse quadro, situam-se as próprias concepções de Adorno a respeito do corpo e, com elas, a respeito do esporte.
POESIA: SENSIBILIDADE OU COMPREENSÃO DO SENTIDO?
Authors: Silva Antonio Manoel dos Santos , Gusmão-Garcia Sílvia Craveiro 
Published: April 2018

Este artigo defende a importÂncia da concepção da poesia como estímulo e participação emotiva. Mostra que ao situar a poesia no dominio da sensibilidade podemos fazer com que os poemas se tornem instrumentos fundamentais para a educação das crianças. Vale-se para isso não só dos resultados de pesquisas realizadas em escolas, mas também do testemunho de poetas e da experiência de fruição e jogo com poema de Maiakóvski , traduzido por Augusto de Campos.
ALFABETIZAÇÃO NAS DÉCADAS DE 1950-1980, SEGUNDO REGISTROS DE MEMÓRIAS: UM ESTUDO SOBRE AS PRÁTICAS PEDAGÓGICAS E A PRESENÇA E SIGNIFICADO DA FAMÍLIA NO PERÍODO DA ALFABETIZAÇÃO
Authors: Grigoli Josefa Aparecida Gonçalves 
Published: April 2018

Neste trabalho são apresentados resultados de um estudo sobre Memórias da Alfabetização. A análise dessas memórias foi orientada pelas seguintes questões: (1) Quais lembranças do período da alfabetização ficaram registradas na memória dos participantes e quais os sentimentos a elas relacionados? (2) Que temas são recorrentes nelas? (3) Como a família e as relações familiares comparecem nas memórias? Considerando a diversidade dos sujeitos quanto à procedência (diferentes regiões do país) e à época em que foram alfabetizados (décadas de 50 a 80) acredita-se que as memórias expressem diferentes representações acerca da escola e das suas práticas, dos métodos de alfabetização e das experiências vividas, no espaço da escola e nas relações familiares. A análise desses registros tem possibilitado resgatar, sob um enfoque singular, alguns traços significativos da história da alfabetização, das práticas das professoras e da cultura escolar e familiar, ao longo dessas quatro décadas, na escola brasileira.