bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building Capacity in Long-Term Care: Supporting Homes to Provide Intravenous Therapy
Authors: Papaioannou Alexandra , Hazzan Afeez Abiola , Ioannidis George , O'Donnell Denis , Broadhurst Daphne , Navare Hrishikesh , Hillier Loretta M. , Simpson Diane , Loeb Mark 
Published: December 2018

BackgroundTypically, long-term care home (LTCH) residents are transferred to hospital to access intravenous (IV) therapy. The aim of this study was to pilot-test an in-home IV therapy service, and to de-scribe outcomes and key informants’ perceptions of this service.MethodThis service was pilot-tested in four LTCH in the Hamilton-Niagara region, Ontario. Interviews were conducted with six caregivers of residents who received IV therapy and ten key informants representing LTC home staff and service partners to assess their perceptions of the service. A chart review was conducted to describe the resident population served and service implementation.ResultsTwelve residents received IV therapy. This service potentially avoided nine emergency department visits and reduced hospital lengths of stay for three residents whose IV therapy was initi-ated in hospital. There were no adverse events. The service was well received by caregivers and key informants, as it provided care in a familiar environment and was perceived to be lessstressful and better quality care than when provided in hospital. ConclusionIV therapy is feasible to implement in LTCHs, particularly when there are supportive resources available and clinical pathways to support decision-making. This service has the potential to increase capacity in LTCHs to provide medical care.
The identification of the species of the ‘Spilogona contractifrons species-group’ and the ‘Spilogona nitidicauda species-group’ (Diptera, Muscidae) based on morphological and molecular analysis
Authors: Sorokina Vera S. , Shaikevich Elena V. 
Published: December 2018

Muscid species of the ‘Spilogona contractifrons species-group’ (Spilogona alticola (Malloch, 1920), S. arctica (Zetterstedt, 1838), S. contractifrons (Zetterstedt, 1838), S. orthosurstyla Xue & Tian, 1988) and of the ‘Spilogona nitidicauda species-group’ (S. nitidicauda (Schnabl, 1911), S. hissarensis Hennig, 1959, S. imitatrix (Malloch, 1921), S. platyfrons Sorokina, 2018) are notoriously difficult to distinguish. In this paper, their morphological features are analysed, images of the male head, frons and abdomen of all the species are given, and the male terminalia are figured. The study of extensive material has shown that all the morphologically recognised species in each of these groups are valid species. An identification key is provided for both groups of species. To confirm the morphological differences, genetic differences in the cytochrome oxidase I gene of flies of the ‘Spilogona contractifrons species-group’ and of the ‘Spilogona nitidicauda species-group’ were analysed. It is shown that members of both groups of species have not only distinguishing morphological characters but also fixed substitutions in the DNA sequences. Since a low interspecific polymorphism is known in the Muscidae Latreille, 1802, the revealed genetic distances confirm the existence of separate species or subspecies in each of the groups studied.
EDITORIAL - DOSSIÊ TEMÁTICO – CIDADES E MOVIMENTOS SOCIOCULTURAIS
Authors: Kocourek Sheila 
Published: December 2018

Este segundo número de 2018 da Revista Sociais e Humanas (RSH), a qual é vinculada ao Centro de Ciências Sociais e Humanas da Universidade Federal de Santa Maria. Agradecemos a todos que colaboraram para a formação desta edição e contamos com a continuidade de suas contribuições, por meio de submissões de artigos, pareceres, revisões, divulgação de pesquisas e produções artísticas científicas. Deste modo estaremos cumprindo nosso maior objetivo que é socializar e divulgar o conhecimento e reflexões das diferentes áreas que compõem as Ciências Sociais e Humanas. Chegamos ao volume 31, número 2/2018, da RSH, no qual apresentaremos 14 publicações, divididas em: Dossiê Temático – Cidades e Movimentos Socioculturais – (4 artigos); Artigos Livres (9 artigos); e Produção Artístico Científica (01 artigo).
Un sello inédito sobre dolium del Municipium Cascantum (Cascante, Navarra)
Authors: Gómara Miramón Marta , Andreu Pintado Javier , Serrano Arnáez Begoña , Santos Horneros Ángel , Bonilla Santander Óscar , Pérez Aranda Miriam 
Published: December 2018

En este trabajo damos a conocer un contexto arqueológico de una de las villae que dibujaron el paisaje rural en el Valle del Queiles durante época altoimperial romana. Se trata del yacimiento arqueológico de “Piecordero I” que está siendo excavado ininterrumpidamente desde el año 2007; las numerosas campañas de prospección y excavación arqueológica realizadas nos están permitiendo conocer la cultura material de este tipo de asentamientos en el ager de Cascantum, así como la articulación de la sociedad que la habitó. El estudio se centra en un sello sobre dolia inédito localizado en la pars rustica, que nos aporta nuevos datos sobre la élite local y el paisaje productivo agrícola en época Altoimperial.
Carbon–Heteroatom Bond Formation Mediated by Hypervalent Iodine
Authors: Romero R. Martin , Muñiz Kilian 
Published: December 2018

AbstractThis chapter describes the recent progress in hypervalent iodine‐mediated oxidative Csp, Csp2, and Csp3transformations for carbon–heteroatom bond formation. The individual reactions are discussed with a focus on mechanistic details, and emphasis is made to the nature of the employed hypervalent iodine reagents.
Hierarchical Ni(OH)2‐MnO2 Array as Supercapacitor Electrode with High Capacity
Authors: Li Jiangwei , Wei Chengbo , Sun Yanfang , Liu Qingyun , Zhang Xiao , Guo Jinxue 
Published: December 2018

AbstractNanoarray electrodes with highly capacitive materials and specific architectures are hopeful to realize advanced supercapacitor performance. The nickel foam (NF) supported hierarchical nanosheet array electrode is fabricated through a template route toward excellent capacitive supercapacitor. The hierarchical nanosheet array weaved with Ni(OH)2‐MnO2 nanowires provides multiple advantages for porous feature, high surface area, and fast charge transfer. The neighbored Ni(OH)2‐MnO2 supplies lattice fringes distortion as additional active sites as well as synergism, for improved capacitive performances. As expected, the Ni(OH)2‐MnO2/NF electrode manifests high specific capacitance of 14.7 F cm−2 at 2.5 mA cm−2 and good cyclic stability, making it hopeful for highly capacitive supercapacitor application.
Highly Sensitive, Affordable, and Adaptable Refractive Index Sensing with Silicon‐Based Dielectric Metasurfaces
Authors: Ollanik Adam J. , Oguntoye Isaac O. , Hartfield George Z. , Escarra Matthew D. 
Published: December 2018

AbstractA sensing platform is presented that uses dielectric Huygens source metasurfaces to measure refractive index changes in a microfluidic channel with experimentally measured sensitivity of 323 nm RIU−1, a figure of merit (FOM) of 5.4, and a response of 8.2 (820%) change in transmittance per refractive index unit (T/RIU). Changes in the refractive index of liquids flown through the channel are measured by single‐wavelength transmittance measurement, requiring only a simple light source and photodetector, significantly reducing device expense in comparison to state‐of‐the‐art refractive index sensing technologies. A technoeconomic analysis predicts a device costing ≈$2400 that is capable of detecting refractive index changes of the order of 2*10−8. The metasurfaces utilized are low profile, scalable, and use materials and fabrication processes compatible with CMOS and other technologies making them suitable for device integration. The Huygens metasurface system, characterized by spectrally overlapping electric and magnetic dipole modes, offers a high degree of customizability. Interplay between the two resonances may be controlled via metasurface geometry, leading to tunability of device sensitivity and measurement range. Ultrahigh sensitivity of 350 nm RIU−1 with FOM of 219, corresponding to single‐wavelength sensitivity of 360 RIU−1, is demonstrated computationally through use of antisymmetric resonances of a Huygens metasurface illuminated at small incidence angles.
Chiral events in developing gametophores of Physcomitrella patens and other moss species are driven by an unknown, universal direction‐sensing mechanism
Authors: Zagórska‐Marek Beata , Sokołowska Katarzyna , Turzańska Magdalena 
Published: December 2018

Premise of the StudyWe used the model species Physcomitrella patens to examine chirality in moss gametophores. Chirality is manifested in the direction of consecutive apical cell divisions, cell plate configurations, and deviations of leaf connecting lines from the vertical course. However, the frequencies of chiral configurations of all these processes as well as their mutual dependence—especially in the case of gametophore branching—are not known. Other moss species were checked to determine the universality of our findings.MethodsThe gametophore structure of Physcomitrella patens grown in the laboratory under controlled conditions was investigated using light microscopy and compared with that of other moss species collected from their natural stands.Key ResultsIn all investigated moss species, the tetrahedral apical cell exhibits either clockwise or counterclockwise consecutive divisions, and selection of this directionality in the primary axis is random. It is, however, related to cell plate configuration. If the plate is skewed, leaf‐producing segments arising from the apical cell cleavage exhibit circumferential rotation. Three parallel lines connecting the leaves deviate from a vertical course, but always in the same direction as that of leaf initiation; thus, the angular distance between consecutive leaves increases to >120°. Lateral branches are exclusively antidromous.ConclusionsGametophore chiral configuration appears to be useful in resolving problems of moss modular growth and branching. Morphological and anatomical evidence strongly suggests that an unknown direction‐sensing mechanism controls the development of moss axial organs. We propose that leaves are responsible for a horizontal gradient of sugar signals that develops along the gametophore circumference, thus influencing branching‐unit chirality.
Hin und zurück – die Entwicklung von LiNiO2 als Kathodenaktivmaterial
Authors: Bianchini Matteo , Roca‐Ayats Maria , Hartmann Pascal , Brezesinski Torsten , Janek Jürgen 
Published: December 2018

AbstractWir geben in diesem Aufsatz einen umfassenden Überblick über LiNiO2 (LNO), fast 30 Jahre nach seiner ursprünglichen Einführung als Kathodenaktivmaterial. Ziel ist es, diejenigen physikalisch‐chemischen Eigenschaften hervorzuheben, die LNO in jeder Hinsicht zu einem komplexen Material machen. Der Effekt der Lithium‐Nichtstöchiometrie (Li1−zNi1+zO2) spielt hierbei eine wichtige Rolle. Sie beeinflusst jede Eigenschaft von LNO, besonders das elektrochemische Verhalten. Die wichtigsten Instabilitätsprobleme, die das Material beeinträchtigen, und die Strategien, die bislang implementiert wurden, um diese Probleme zu lösen, werden im Detail diskutiert. Schließlich werden die wichtigsten offenen Fragen, die vor einer nachhaltigen Nutzung von LNO noch zu klären sind, zusammengefasst, und es wird erläutert, welche Forschungsrichtungen vielversprechend sind, um das volle Potential von LNO zu nutzen.
Dopamine, Oxidative Stress and Protein–Quinone Modifications in Parkinson's and Other Neurodegenerative Diseases
Authors: Monzani Enrico , Nicolis Stefania , Dell'Acqua Simone , Capucciati Andrea , Bacchella Chiara , Zucca Fabio A. , Mosharov Eugene V. , Sulzer David , Zecca Luigi , Casella Luigi 
Published: December 2018

AbstractDopamine (DA) is the most important catecholamine in the brain, as it is the most abundant and the precursor of other neurotransmitters. Degeneration of nigrostriatal neurons of substantia nigra pars compacta in Parkinson's disease represents the best‐studied link between DA neurotransmission and neuropathology. Catecholamines are reactive molecules that are handled through complex control and transport systems. Under normal conditions, small amounts of cytosolic DA are converted to neuromelanin in a stepwise process involving melanization of peptides and proteins. However, excessive cytosolic or extraneuronal DA can give rise to nonselective protein modifications. These reactions involve DA oxidation to quinone species and depend on the presence of redox‐active transition metal ions such as iron and copper. Other oxidized DA metabolites likely participate in post‐translational protein modification. Thus, protein–quinone modification is a heterogeneous process involving multiple DA‐derived residues that produce structural and conformational changes of proteins and can lead to aggregation and inactivation of the modified proteins.
Microsatellite primer development for the invasive perennial herb Gypsophila paniculata (Caryophyllaceae)
Authors: Leimbach‐Maus Hailee B. , Parks Syndell R. , Partridge Charlyn G. 
Published: December 2018

Premise of the StudyGypsophila paniculata (baby's breath; Caryophyllaceae) is a herbaceous perennial that has invaded much of northern and western United States and Canada, outcompeting and crowding out native and endemic species. Microsatellite primers were developed to analyze the genetic structure of invasive populations.Methods and ResultsWe identified 16 polymorphic nuclear microsatellite loci for G. paniculata out of 73 loci that successfully amplified from a primer library created using Illumina sequencing technology. Microsatellite primers were developed to amplify di‐, tri‐, and tetranucleotide repeats and tested in three invasive populations in Michigan.ConclusionsThese markers will be useful in characterizing the genetic structure of invasive populations throughout North America to aid targeted management efforts, and in native Eurasian populations to better understand invasion history. Five of these developed primers also amplified in G. elegans.
Profile and Motivations of Registered Whole‐Body Donors in Turkey: Istanbul University Experience
Authors: Gürses İlke Ali , Ertaş Ahmet , Gürtekin Başak , Coşkun Osman , Üzel Mehmet , Gayretli Özcan , Demirci Mehmet Selman 
Published: December 2018

Little is known regarding the profiles of whole body donors in Muslim majority countries where donation is scarce. Therefore, this study aims to profile registered donors in Turkey by means of a survey. The explored data could be used to improve ongoing campaign efforts and ethical practices such as commemoration services. Registered donors of the donation programs at the two faculties of medicine of Istanbul University were compared with the national population and a cluster analysis was performed to reveal any concealed sub‐groups. Data from 188 respondents were analyzed. The majority of registered donors were married (42%), male (65.4%), aged over 50 years (76%), held a tertiary education degree (49.7%), and were irreligious (58.5%). Cluster analysis revealed two groups with significantly different educational levels, marital statuses, and religious choices. Regarding whether their bodies could be used for education or research, the majority (64.5%) of the respondents left the decision to the anatomy department. Similarly, 73.8% approved indefinite use of their organs, body parts and/or skeletons. The respondents were also willing to share their medical history (94.2%) and personal information (81.6%) if needed. Motivational themes for body donation including usefulness, impermanence, religion, awareness, and kinship were devised after a thematic analysis. Among the respondents, 56.5% were registered organ donors and 63.3% were frequent blood donors. The results of this study provide data that may help revising informed consent forms, developing and implementing thanksgiving ceremonies, and selecting additional targets for supporting body donation campaign activities such as organ and blood donation units.
Structural analysis of the inhibitory effects of polyphenols, (+)‐hopeaphenol and (−)‐isohopeaphenol, on human SIRT1
Authors: Loisruangsin Arthorn , Hikita Kiyomi , Seto Norikazu , Niwa Masatake , Takaya Yoshiaki , Kaneda Norio 
Published: December 2018

AbstractHuman sirtuin 1 (hSIRT1) is a NAD+‐dependent deacetylase that regulates several cellular processes. Unlike resveratrol, natural polymeric phenolic compounds isolated from Vitaceae are mostly hSIRT1 inhibitors. The resveratrol tetramer, (+)‐hopeaphenol ((+)‐HP), and its geometric isomer, (−)‐isohopeaphenol ((−)‐iHP), were tested for inhibitory effects on purified hSIRT1 using a fluorescent derivative of peptide substrate p53‐AMC (Fluor de Lys) and a cofactor NAD+. The Lineweaver–Burk plots indicated that both (+)‐HP and (−)‐iHP were competitive inhibitors against NAD+. Computer‐assisted modeling of the binding of these molecules with hSIRT1 protein provided the most feasible conformation of the enzyme–inhibitor complex. © 2018 BioFactors, 45(2):253–258, 2019
Sustainable development disclosure: Environmental, social, and governance reporting and gender diversity in the audit committee
Authors: Bravo Francisco , Reguera‐Alvarado Nuria 
Published: December 2018

AbstractThis paper analyzes the link between female representation on audit committees (ACs) and specific information attributes of environmental, social, and governance (ESG) disclosures. We also examine whether the role of women is moderated by the busyness and intensity of the committee. Our results reveal a positive association between gender diversity in the AC and the quality of voluntary ESG reporting, which results in greater comprehensiveness and relevance. These findings extend the academic debate concerning the role of female directors on sustainability policies. Moreover, given the importance of ESG information in capital markets and its potential benefits for firms, this evidence may help regulators and owners to implement adequate corporate governance mechanisms. In addition, the busyness of the AC negatively moderates the influence of female AC members. Therefore, we highlight the need to consider the context in which women work in order to understand their influence on sustainability reporting.
Chief executive officer ability, corporate social responsibility, and financial performance: The moderating role of the environment
Authors: García‐Sánchez Isabel‐María , Martínez‐Ferrero Jennifer 
Published: December 2018

AbstractThis paper seeks to explore how chief executive officer (CEO) ability influences the economic impact of corporate social responsibility strategic decisions. Currently, the evidence on the impact of corporate social responsibility on the value of the company is mixed; in this paper, we aim to observe the moderate role played by this particularity of the CEO in the relationship between socially responsible commitment and financial performance. Our results identify that the most able CEOs make investments in social and environmental practices that lead to greater financial performance; in contrast, the less able CEOs can overinvest or underinvest in an opportunistic way for personal benefit at shareholders' expense. In addition, the role that CEO ability plays in social and environmental strategies is particularly pertinent in munificent environments that foment managerial discretion; in these contexts, high managerial ability leads to investment in socially responsible performance, which benefits shareholders by alleviating moral hazard.
Rational Structure‐Based Design of Fluorescent Probes for Amyloid Folds
Authors: Orts Julien , Aulikki Wälti Marielle , Ghosh Dhiman , Campioni Silvia , Saupe Sven J. , Riek Roland 
Published: December 2018

AbstractAmyloid fibrils are pathological hallmarks of various human diseases, including Parkinson's, Alzheimer's, amyotrophic lateral sclerosis (ALS or motor neurone disease), and prion diseases. Treatment of the amyloid diseases are hindered, among other factors, by timely detection and therefore, early detection of the amyloid fibrils would be beneficial for treatment against these disorders. Here, a small molecular fluorescent probe is reported that selectively recognize the fibrillar form of amyloid beta(1–42), α‐synuclein, and HET‐s(218–289) protein over their monomeric conformation. The rational design of the reporters relies on the well‐known cross‐β‐sheet repetition motif, the key structural feature of amyloids.
Microbial Production of Natural and Unnatural Monolignols with Escherichia coli
Authors: Aschenbrenner Jennifer , Marx Patrick , Pietruszka Jörg , Marienhagen Jan 
Published: December 2018

AbstractPhenylpropanoids and phenylpropanoid‐derived plant polyphenols find numerous applications in the food and pharmaceutical industries. In recent years, several microbial platform organisms have been engineered towards producing such compounds. However, for the most part, microbial (poly)phenol production is inspired by nature, so naturally occurring compounds have predominantly been produced to date.Here we have taken advantage of the promiscuity of the enzymes involved in phenylpropanoid synthesis and exploited the versatility of an engineered Escherichia coli strain harboring a synthetic monolignol pathway to convert supplemented natural and unnatural phenylpropenoic acids into their corresponding monolignols. The performed biotransformations showed that this strain is able to catalyze the stepwise reduction of chemically interesting unnatural phenylpropenoic acids such as 3,4,5‐trimethoxycinnamic acid, 5‐bromoferulic acid, 2‐nitroferulic acid, and a “bicyclic” p‐coumaric acid derivative, in addition to six naturally occurring phenylpropenoic acids.
Implementation of the transradial approach as an alternative vascular access for transcatheter aortic valve replacement guidance: Experience from a high‐volume center
Authors: Fernandez‐Lopez Leticia , Chevalier Bernard , Lefèvre Thierry , Spaziano Marco , Unterseeh Thierry , Champagne Stéphane , Benamer Hakim , Sanguineti Francesca , Garot Philippe , Hovasse Thomas 
Published: December 2018

AbstractObjectiveThis study sought to assess the potential benefits of the transradial approach (TRA) as an alternative vascular access to the classical contralateral femoral approach for transcatheter aortic valve replacement (TAVR).BackgroundVascular and bleeding complications in TAVR have gradually decreased owing to operator experience and downsizing of the delivery system. However, about 1/4 of vascular access site complications are related to the transfemoral (TF) secondary access.MethodsWe compared the outcomes at 30 days according to VARC‐2 after TAVR of a prospective cohort of 217 consecutive patients undergoing right or left TRA as the second vascular access (TRA‐TF TAVR) and a retrospective cohort of 194 consecutive patients undergoing TF approach as a second vascular access (TF‐TF TAVR).ResultsBaseline clinical characteristics and risk scores were well matched in both groups. Procedural success rate was 99.7%. Fluoro time was significantly lower in the TF‐TF TAVR group (16.9 ± 7.2 vs. 19.1 ± 7.8 min, P = 0.003); however, there was no significant difference in x‐ray exposure, procedure time or amount of contrast used. In the TRA‐TF TAVR group, there were no complications related to the TRA access and there were less vascular and bleeding complications (18.0% vs. 9.7%, P = 0.014; 17.0% vs. 9.2%, P = 0.026, respectively), although blood transfusion requirement or hospitalization duration stay were similar in both groups.ConclusionsTRA approach as alternative secondary vascular access in TAVR is safe and feasible and is associated with a significant decrease in vascular and bleeding complications. Further, large‐scale studies are warranted to confirm the potential benefit of this approach.