bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative clinical and encephalographic study on manifestation of the choline and dopamine deficiency syndromes in consciousness recovery after severe traumatic brain injury
Authors: Postnikova M. V. Chelyapina – , Sharova E. V. , Zaitsev О.S. 
Published: July 2019

Purpose: to describe and compare the severity of clinical signs of choline and dopamine deficiency and their EEG manifestation in consciousness recovery of patients with sTBI.
Material and methods: The data of dynamic and clinical EEG studies of 98 patients (68
men, 30 women) with severe traumatic brain injury were analysed. The patients were aged
13 to 57 y.o. (mean 31 ± 12 y.o). The observation period ranged from 3 weeks to 20 months after trauma. The analysis assessed the neurological status and mental activity in patients, including EEG studies with a dynamic pattern assessment.
Results: the EEG pattern of dopamine deficiency syndrome featured emerging synchronised beta activity at 13-14 Hz with a significant rise in the frontal and anterior temporal regions, concurrent with a general decrease of biopotential amplitude, EEG flattening and smoothing differences between zones, as well as more or less pronounced theta rhythms. In patients with choline deficiency syndrome, alpha activity of 7–8 sec (no matter how unstable, disorganized and slow) came to be most characteristic, even in cases of deeply depressed consciousness (coma). Alpha activity was combined with an increased diffuse fast activity or polymorphic (rhythmic) groups of theta-delta waves in the EEG pattern during a general disorganization of biopotentials.
Role of Polymerase Chain Reaction in diagnosis of Tuberculosis as compared to routine tests
Authors: Memon Dr Haris , Haroon Mujtaba Memon Dr Muhammad , Shahab Dr Mahum , Iqbal Dr Mahmood , Murtaza Memon Dr Ghulam 
Published: July 2019

Introduction: There is a need for rapid and sensitive detection of Mycobacterium tuberculosis in clinical samples. A study was conducted in which the target for the amplification being a segment of IS6110 in the M. tuberculosis chromosome was evaluated using real time PCR and its results were compared with routine tests, using pulmonary and extra-pulmonary specimen.
Methods: In this descriptive cross-sectional retrospective study, specificity and sensitivity of PCR were analyzed. A total of 293 clinical samples were processed at a tertiary care hospital of Peshawar, during the time period of 2016-2018, from patients suspected of having pulmonary and extra-pulmonary tuberculosis and Follow up patients with DOTS treatment and MDR treatment that are referred by tertiary hospital were also included in this study after taking their informed consent. Patients not willing to participate in the study were excluded. For identification specimens were stained by Ziehl Neelsen staining (ZN), cultured on Lowenstein–Jensen (LJ) medium and then confirmed by PCR for the detection of Mycobacterium tuberculosis (MTB).
Results: Of the 293 samples, 165(56.3%) were from males and 128(43.7%) females. Mean age was 44 years (2-85 years). Specimen types included: CSF (30.4%), pleural fluid (4.1%), sputum (15%), urine (2.4%), synovial fluid (2.4%), other fluids (33.1%) and biopsies (12.6%). Only 3.1% of specimens were ZN-smear positive for (MTB). LJ culture identified 7.2% whereas PCR method detected (MTB) in 15% of the total specimens. Using PCR as gold standard, ZN microscopy correctly identified 20.5% of total (MTB) positive specimens and LJ culture detected 47.7%.Specimen types showed significant association with PCR test: 42.9% of synovial fluid samples and 41.7% of pleural fluid samples; 28.6% of urine samples were positive for (MTB) by PCR method. This indicates that PCR analysis of these specimens’ exhibit greater positivity rates for (MTB) as opposed to CSF and other fluids and biopsies
Conclusions: TB PCR is a rapid and reliable test in the diagnosis and management of tuberculosis.
Effect of intraoperative radiotherapy on wound healing in breast cancer patient post breast conserving surgery, KSUMC, Riyadh, Saudi Arabia: Case series and review of literature.
Authors: Alghamdi Dr. Maha Alamodi , Altwjri Abdulaziz Saleh , Alsuhaibani Abdullah , Alsaif Abdulaziz 
Published: July 2019

Intraoperative radiotherapy during breast-conserving surgery is being studied as an alternative to 6 weeks of external beam radiotherapy (EBRT) for low-risk women; it can be delivered using electrons (intraoperative electron radiotherapy, IOERT) or 50-kV X-rays. Intraoperative radiation therapy (IORT) may pose a risk for wound complications. Between March 2018 and June 2018, 5 breast cancer patients, all eligible for breast conserving surgery (BCS), were treated at the King Saud Medical city with IORT using the IOERT. Complete data sets for age, stage (T, N, and M), and histology and hormone receptor status were available in 5 cases. Parameters to identify eligible patients are as follows: ESTRO: >50 years, invasive ductal carcinoma/other favourable histology (IDC), T1-2 (≤3 cm), N0, any hormone receptor status, M0; ASTRO: ≥60 years, IDC, T1, N0, positive estrogen hormone receptor status, M0; TARGIT E “elderly”, risk adapted radiotherapy with IORT followed by external beam radiotherapy in case of risk factors in final histopathology. Consecutive patients operated on with the same surgical technique and given IORT were included. Wound complications were evaluated.
Change Management and Organizational Performance in Selected Manufacturing Companies in Anambra State, Nigeria
Authors: M. N. Okeke , J.C Oboreh, , O. Nebolisa , U.O Esione, , Odemegwu Ojukwu Chukwuemeka 
Published: July 2019

This study examined change management and organizational performance in manufacturing companies in Anambra state, Nigeria. Relevant conceptual, theoretical and empirical literatures were reviewed. This study was anchored on organizational change and Lewin`s Three Step Model . Descriptive survey design was adopted, and primary data was employed. The population for the study was 286 employees working at the selected manufacturing companies in Anambra State. The entire population was used as the sample size for this study.The major instrument used for data collection was the questionnaire. Content Validity was adopted, and the test-retest method was used to test reliability of the research instrument. The study found that technological changes have a positive significant effect on organizational performance in manufacturing companies. Change management strategies have a positive significant effect on organizational performance in manufacturing companies in Anambra state. Leadership changes have a positive significant influence on organizational performance in manufacturing companies in Anambra state. The study concluded that change management has a positive significant effect on organizational performance in manufacturing companies in Anambra state. The study recommends that technology change had influenced employee performance since it simplifies the work to be done,thereby making work more efficient. Organizations which implement new technology should provide proper training to their employees to increase their performance. Every organization should build strong organizational management strategies that help to build good relationships based on their values, norms, behaviours, and perceptions.Leadership changes leaders’ mind-set, style, and behavior.The change process they design as a result of their orientation must encourage employees to want to participate, to choose to contribute, rather than force them to do so.
KITAB JAWI SEBAGAI KARYA KEARIFAN TEMPATAN MELAYU : ANALISIS SEJARAH INTELEKTUAL
Authors: Abd. Rahim Rahimin Affandi , Pawi Awang Azman bin Awang , Abd Jalal Ahmad Farid , Abdul Malik Mohd Puaad Bin 
Published: July 2019

This article examines the treasures of the Arabic Malay books (Kitab Jawi) which have a wealth of Malay local wisdom. There are three important aspects of the contents of the Malay books discussed in this article, namely: (1) uruf and Malay local wisdom; (2) the principle of Malay local wisdom formula and (3) proof of Kitab Jawi as Malay local wisdom that can be promoted at this time. The results of this study confirm several things. First, the awareness of the world community about local wisdom belonging to the community of the non-European may be filled by expressing the concept of local wisdom based on Islamic knowledge. Secondly, the constructs and formulas of Malay local wisdom are indeed rather unique because they are the result of the sentiment between Islam and Malay thought. Third, Kitab Jawi is indeed the most important product of local Malay Islamic wisdom. This can be seen in terms of the formation of Jawi writings and the constructs of science that were awakened by previous Malay scholars. Artikel ini mengkaji khazanah kitab-kitab Arab Melayu (Kitab Jawi) yang memiliki kekayaan akan kearifan lokal Melayu. Ada tiga aspek penting kandungan kitab-kitan Melayu yang dibahas dalam artikel ini, yaitu : (1) uruf dan kearifan lokal Melayu; (2) asas formula kearifan lokal Melayu dan (3) pembuktian kitab jawi sebagai kearifan lokal Melayu yang bisa dipromisikan di masa ini. Hasil kajian ini menegaskan beberapa hal. Pertama, kesadaran masyarakat dunia tentang kearifan lokal milik masyarakat peribumi bukan Eropa boleh diisi dengan mengemukakan konsep kearifan lokal berasaskan ilmu melayu Islam. Kedua, konstruk dan formula kearifan lokal Melayu memang agak unik kerana merupakan hasil sentesis antara Islam dengan pemikiran Melayu. Ketiga, kitab jawi memang merupakan produk kearifan lokal Melayu Islam yang terpenting. Ini dapat dilihat dari segi pembentukan tulisan jawi dan konstruk ilmu yang dibangunkan oleh ulama melayu masa silam.
INTEGRASI ILMU KEISLAMAN DAN FILSAFAT: PERSPEKTIF FILSAFAT ILMU
Authors: Wardani Wardani 
Published: July 2019

This article intends to examine the integration between Islamic studies and philosophy from the philosophy of science perspective. The focus of this study primarily focuses on Islamic studies in Islamic university in Indonesia, regarding the real conditions of its science seen from the perspective of philosophical learning. The second focus is the offer of the philosophy of science approach in developing Islamic studies. The article concludes that Islamic studies at the university are “poor of philosophy" because the direction of the study is mostly dominated by normative studies. Therefore, as the first step, the bachelor degree in all faculties of Islamic university should study philosophy of science, it is also necessary to develop Islamic studies from the philosophy of science perspective, such as the philosophy proposed by Thomas Kuhn and Imre Lakatos.
MODELAGEM HIDRO-METEOCEANOGRÁFICA PARA VIAS FLUVIAIS E PORTOS - PREHVIA
Authors: Olivas Kaji Aline , De Almeida Bressiani Danielle , Gamboa-Medina Maria Mercedes , Cossetin Ferreira Camila , Salgueiro Donato Bacelar Luiz Carlos 
Published: July 2019

Apesar do grande potencial para o transporte aquaviário no Brasil, este modal ainda é pouco explorado. No entanto sua utilização para transporte de cargas, dados seus diferenciais competitivos (como menores custo e impactos ambientais, maior segurança e concentração de cargas), tem aumentado. Os recentes avanços da ciência, capacidade observacional e computacional no desenvolvimento de previsões ambientais mais confiáveis podem auxiliar no suporte à decisão e planejamento de operações ao longo de hidrovias e portos. Está sendo desenvolvida uma ferramenta de suporte ao planejamento e logística da navegação interior: PreHvia – Previsão Hidro-meteoceanográfica das vias fluviais e portos. Esta ferramenta web trará informações de previsão meteorológica e climática, assim como de vazão e cotas dos rios, e de altura d’água, corrente e onda na região próxima aos portos. Até o presente momento, o desenvolvimento da ferramenta é focado na região Amazônica, em especial para a hidrovia Tapajós-Amazonas e portos do Arquipélago da Ilha do Marajó, mas visiona a expansão para as demais hidrovias e portos brasileiros. Esse artigo discute as diversas metodologias e modelos numéricos, que estão sendo desenvolvidos e validados para previsões de tempo, clima, hidrológicas, hidrodinâmicas e oceânicas, assim como os resultados preliminares, dificuldades encontradas, os próximos passos e oportunidades para desenvolvimentos futuros. A ferramenta PreHvia é formada por quatro módulos principais: com modelos atmosférico e climático regionais, modelo hidrológico da bacia do Tapajós-Amazonas, modelo hidrodinâmico do Arquipélago de Marajó e modelo de ondas da região costeira e do Arquipélago de Marajó. Os diferentes modelos são acoplados formando um sistema de previsão de variáveis ambientais para os próximos dias, além do monitoramento e de uma climatologia e estatísticas que irão permitir o planejamento a longo prazo. A ferramenta fornecerá informações essenciais para um bom planejamento e operações eficientes, com maior segurança e menor riscos nas hidrovias e portos do país.
PENGARUH METODE LATIHAN DAN KORDINASI MATA – KAKI TERHADAP KETERAMPILAN SHOOTING DALAM SEPAKBOLA
Authors: Habibie Muhammad , Widiastuti Widiastuti , Nuriani Sri 
Published: July 2019

Penelitian ini bertujuan untuk mengetahui pengaruh metode Latihan dan kordinasi mata-kaki terhadap keterampilan shooting dalam sepakbola. Sampel penelitian ini berjumlah 40 orang yang merupakan Mahasiswa Universitas Lambung Mangkurat yang sudah lulus mata kuliah sepakbola dengan menggunakan rancangan penelitian treatment by level 2 x 2. Data dianalisis menggunakan analisis varians (ANAVA) dan dilanjutkan dengan uji Tukey pada taraf signifikansi α = 0,05. Hasil penelitian menunjukkan (1) secara umum, terdapat perbedaan antara metode latihan bodyweight squats dan Metode latihan flexibility dinamis terhadap keterampilan shooting dalam sepakbolai (Fo 7.8312>4,11 Ft), dan metode latihan bodyweight squats memberikan hasil keterampilan shooting dalam sepakbola yang lebih baik daripada latihan flexibility dinamis, (2) terdapat interaksi antara metode latihan dan kordinasi mata-kaki terhadap hasil keterampilan shooting dalam sepakbola (Fo 5.789>4,11 Ft), (3) pada pemain dengan kordinasi mata-kaki tinggi, metode latihan bodyweight squats memberikan hasil keterampilan sooting yang lebih baik daripada metode latihan Fexibility dinamis (Qo3,21> 2,86 Qt), dan (4) pada pemain dengan kordinasi mata-kaki rendah, tidak memberikan pengaruh signifikan pada hasil keterampilan shooting dalam sepakbola dengan metode latihan bodyweight squats dan Metode latihan flexibility dinamis (Qo-1,25< 3,97 Qt). Kata kunci: Shooing Sepakbola, Metode Latihan, Bodyweight Squats, Flexibility Dinamis, Dan Koordinasi Mata-Kaki.
Rate-Transient Analysis Based on the Power-Law Behavior for Permian Wells
Authors: Chu W.–C.. –C. , Pandya N. D. , Flumerfelt R. W. , Chen C.. 
Published: July 2019

Summary
In unconventional reservoirs, the application of many rate–transient–analysis (RTA) techniques relies heavily on the identification and analysis of the linear flow regime, which is characterized by a ½–slope on a log–log plot of Δp vs. t. Through our analysis of more than 400 wells with downhole pressure gauges in the Wolfcamp Shale of the Permian Basin, we observed power–law behavior, but with slopes much different from ½ over long periods of time. In many cases, the duration of the straight line with a slope different from ½ lasts for years, without ever converging to ½. In some cases, the slope changes over time but is rarely the characteristic ½–slope observed over long periods. Rate forecasts would be in error if we were to assume that the slope would converge to a ½–slope at a later time.
In this work, we present examples of Permian Wolfcamp horizontal wells each with a measured bottomhole pressure (BHP) to demonstrate the characteristic power–law behavior with slopes different from ½. Power–law behaviors are typical in heterogeneous systems and are identified using the Chow pressure group (CPG).
On the basis of the concept of power–law behavior, we developed a workflow to analyze single–phase rate–transient data with high–quality measured BHP. Ultimately, the new workflow for RTA uses power–law characteristics to evaluate well performance and is a complementary tool to traditional methods such as the Arps decline–curve analysis (Arps 1945). In this paper, we outline a power–law analysis workflow scheme and demonstrate that the CPG is a convenient means for identifying the exponents of straight lines. In addition, we present case studies to demonstrate the application of this technique to predict the long–term well performance from choked–back wells, to evaluate long–term performance changes associated with offset fracture hits, and to estimate the hyperbolic–decline–curve b–factor.
On the Sealability of Metal-to-Metal Seals With Application to Premium Casing and Tubing Connections
Authors: Ernens Dennis , Pérez–Ràfols Francesc , Hoecke Dennis Van , Roijmans Roel F. , van Riet Egbert J. , Vande Voorde John B. , Almqvist Andreas , Bas de Rooij Matthijn , Roggeband Serge Mathieu , van Haaften Willem Maarten , Vanderschueren Marc , Thibaux Phillipe , Pasaribu Henry Rihard 
Published: July 2019

Summary
Metal–to–metal seals are used in connections of casing and tubing in oil and gas wells. This paper describes the mechanisms of sealing metal–to–metal seals as investigated using an experimental setup and a stochastic numerical sealing model. Experiments were conducted for a variety of thread compounds and applied pin/box surface coatings. The results were used to validate a stochastic numerical sealing model for sealability. The model couples a contact–mechanics model with a flow model and takes into account the influence of all the surface–topography features by introducing the concept of seal permeability. Once validated, the model was used together with the experimental results to better understand the sealing mechanisms of metal–to–metal seals.
The sealing configuration is a face seal with an 80–mm roundoff radius on one face pressing against a flat on the other face. The face–seal specimens were manufactured from P110 tubing to ensure material properties that are representative for casing or tubing. The test setup used is designed for investigating only the metal–to–metal seal of the connection. The setup can perform rotary sliding under constant load to simulate surface changes during makeup and subsequently perform a leakage test. The sealing limit is determined by applying 700–bar fluid pressure and then gradually reducing the normal force until leakage is observed. The data are subsequently used to validate the previously published stochastic numerical sealing model.
The results indicate a strong dependence on the type of thread compound used for the onset of leakage. The thread compound affects the amount of wear and thus changes the surface topography of the interacting surfaces. It is shown that the stochastic numerical sealing model is capable of predicting the onset of leakage within the experimental accuracy. The model shows further that certain surface topographical features improve the sealing performance. In particular, a surface manufactured by turning on a lathe that is in contact with, for instance, a smooth shot–blasted surface topography leads to highly localized contact areas, which in turn yield the best sealing performance.
Viewership footprint for a low-resource, student-centred collaborative video platform to teach Orthopaedics in Southern Africa
Authors: Wever Gideon Stephanus , Elliott Ian , McCaul Jeannie , Laubscher Maritz , Dunn Robert N , Held Michael 
Published: July 2019

Abstract
Introduction
Institutions are increasingly using technology to augment the class learning experience of medical students. Especially in Africa, local content is key to allow insights and knowledge to emerge and build transformative capacity for students and patients. There is currently no peer-reviewed video content produced to provide insight into Orthopaedic conditions for medical students and patients in this region. Our goal was to evaluate the demographic and geographic viewership as well as video-specific statistics of orthopaedic teaching videos for medical students on a YouTube channel, with the expressed aim of informing future content production.

Methods
Videos were produced by local medical students for their in problem-based collaborative projects. Student-owned smartphones and various free video editing software were used to produce these videos, which were then assessed by a group of orthopaedic specialists and uploaded onto a Youtube channel (UCTeach). The analytic reports of this channel generated by Google and YouTube were analysed regarding watch time per day (minutes), average view duration (minutes), most watched videos, top geographies, age, and gender.

Results
A total of 83 videos of the UCTeachOrtho Channel where uploaded in a two year period with a total watch time of 857 062 minutes and 337 983 views. The majority of viewers where between the ages 18 and 34 years (85%). India had the most views (n=69,089) followed by the United States (n=66,257) and South Africa (n=21,882). Most of the videos where watched on mobile phones (n= 183,299) and computers (n=128,228). The most watched video was produced in April 2016 on physiological and pathological gait with 51,314 views.

Conclusion
Our study highlights that a low-cost collaborative video project can lead to high view counts and watch time on YouTube, and is accessible to an audience in low and middle income countries. Student-centred local content in orthopaedic surgery also reached a global audience consistently over a two-year period.
Survival Benefits of Androgen Receptor Signaling-Axis Inhibitor’s at The Cost of Adverse Event Occurrence: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Zheng Xiaonan , Zhao Xiaohui , Xu Hang , Han Xin , Xu He , Dong Xin , Peng Ruilin , Yang Lu , Wei Qiang , Ai Jianzhong 
Published: July 2019

Abstract
Background: Previous evidence directly evaluating the efficacy and safety of the treatment for castration-resistant prostate cancer (CRPC) by androgen receptor (AR) signaling-axis inhibitors was limited by the quantity of randomized controlled trials (RCT) and biased by non-RCTs. We aim to comprehensively assess the efficacy and safety of abiraterone and enzalutamide using only RCTs.
Patients and methods: We systematically searched Pubmed, Embase, MEDLINE and ClinicalTrial.gov for RCTs providing data of treatment outcomes by AR inhibitors (abiraterone and enzalutamide). Pooled hazard ratios (HR) with 95%CI for survival benefits were calculated using STATA 12.0. Comparison of prostate-specific antigen (PSA) response rate, aggregated adverse event (AE) statistics, any grade AE, high-grade AE (grade ≥3), AE of special interest between the treatment and control groups were performed by RevMan 5.3 and STATA 12.0.
Results: Eight eligible RCTs with 6296 patients were selected. Pooled HR were 0.72 for overall survival, 0.45 for radiographic progression-free survival and 0.36 for PSA PFS. AR inhibitors could significantly increase the rate of PSA response (OR=8.67, 95%CI 4.42-17.04) and AE occurrence (OR=1.98, 95%CI 1.46-2.68). The treatment group had a higher occurrence of any-grade fatigue (OR=1.34, 95%CI 1.20-1.49), back pain (OR=1.15, 95%CI 1.01-1.15), hot flush (OR=1.76, 95%CI 1.50-2.06), diarrhea (OR=1.22, 95%CI 1.07-2.40) and arthralgia (OR=1.34, 95%CI 1.16-1.54). Particularly, the outcomes for AEs of special interest including any grade hypertension (OR=2.06, 95%CI 1.71-2.47), hypokalemia (OR=1.80, 95%CI 1.42-2.30) and fluid retention or edema (OR=1.38, 95%CI 1.17-1.63) also favored the control group. In terms of high-grade AEs, a higher occurrence of hypertension (OR=2.60, 95%CI 1.79-3.79) and pain in extremity (OR=4.46, 95%CI 2.81-7.07) was observed in the treatment group. There was no significant difference regarding other AEs analyzed in this study.
Conclusion: The survival benefits by AR inhibitors for CRPC were evident and promising at the cost of acceptably higher risk of AEs occurrence.