bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology and economic burden of Wilson disease in France: A nationwide population‐based study
Authors: Fang Shona , Furegato Martina , Azzi Jessica , Couchonnal‐Bedoya Eduardo , Debray Dominique 
Published: November 2024

AbstractWilson disease (WD) is a rare inherited copper metabolism disorder characterized by progressive pathological deposition of copper, primarily in the liver and brain. This longitudinal retrospective study conducted using the French national claims (Système National des Données de Santé [SNDS]) database assessed WD prevalence in France, described patients' characterizations and healthcare resource use and associated costs. Patients with WD were identified from SNDS using the International Classification of Diseases, 10th Revision code E83.0 for copper metabolism disorder or a long‐term disease (affection de longue durée [ALD]) associated with this code between 2010 and 2019. Patients were categorized into hepatic, neurological, and psychiatric sub‐cohorts. We identified 2287 patients with WD yielding a crude prevalence of 1 case per 33 898 individuals in 2019. The mean age at inclusion was 39.9 (standard deviation [SD] 22.8) years, 11 years more than that of the incident cohort (28.6, SD 20.3) identified via ALD, and 1180 (51.6%) patients were male. The crude mortality was 3.2% (in total 370 patients died). Overall, 1011 (44.2%), 754 (33.0%), and 414 (18.1%) patients experienced hepatic, neurological, and psychiatric manifestations, respectively. In total, 922 (40.3%) patients were reimbursed for WD‐specific treatment, the most common being D‐penicillamine (74.8%), and 201 (8.8%) underwent liver transplantation. The average annual hospitalization cost per patient was 4273.7€ (SD 11916.0). At least one sick leave was reported for 533 (23.3%) patients, with an annual average cost of 788.7€ (SD 1328.6). Our findings provide an updated understanding of the prevalence of WD, and indicate a considerable level of morbidity in this population, as well as a high level of direct/indirect costs associated with WD.
Prospective association between food protein‐induced allergic proctocolitis in infancy and constipation after age 3
Authors: Marget Michael , Baker Corey , O'Connell Isabel , Shreffler Wayne G. , Yuan Qian , Martin Victoria M. 
Published: November 2024

AbstractWe sought to prospectively evaluate whether food protein‐induced allergic proctocolitis (FPIAP) during infancy is associated with increased constipation later in childhood. Using the Gastrointestinal Microbiome and Allergic Proctocolitis (GMAP) cohort, we reviewed charts of children with prospective parent‐reported constipation after age 3 to confirm the diagnosis of constipation. A diagnosis of FPIAP was based on pediatrician diagnosis and required guaiac‐positive or grossly bloody stools, as previously published. Three hundred and seventy‐five subjects had sufficient data for these analyses. Subjects with FPIAP had more than two times the odds of developing constipation after age 3 compared to subjects without (odds ratio [OR]: 2.62, 95% confidence interval [CI]: [1.42–4.74], p = 0.002). The use of stimulant laxatives was also higher in children with FPIAP (OR: 4.68, 95% CI: [1.47–16.04], p = 0.01). FPIAP was prospectively associated with the later development of constipation after age 3. This may suggest shared underlying pathogenesis, resultant heightened visceral hypersensitivity, and/or intestinal dysbiosis, all warranting further study.
Magnetoplasmonic Gratings Induced an Unusual Magneto‐Optical Kerr Effect at Optical Frequencies
Authors: Cheng Tong‐Huai , Yang Weihao , Sun Shixin , Liu Zhaochao , Yu Feng Hua , Qin Jun , Bi Lei , Luo Feng 
Published: November 2024

AbstractTransverse magneto‐optical Kerr effect (TMOKE) has attracted much attention due to its widespread application in nonreciprocal photon and sensing devices. The vast majority of studies related to TMOKE are mainly focused on p‐polarized incidence as a result of the stereotype that only p‐polarized incidence can generate TMOKE in conventional magnetic materials. Thanks to the powerful ability of metamaterials to regulate light, in recent years, the TMOKE under s‐polarized incidence is explored and observed successfully. Nevertheless, different from the universality and high amplitude of p‐polarized TMOKE, the excitation of s‐polarized TMOKE is pretty rare, and the peak values of s‐polarized TMOKE in the reported research are really weak, which limits its application potential to a large extent. Here, the iron‐based grating structure is proposed that excites surface plasmon polaritons (SPPs) and then causes the highest peak value of s‐polarized TMOKE at optical frequencies to date, which is seven orders of magnitude higher than that of the planar Fe film. Besides, its refractive index sensitivity reaches up to 685 nm RIU−1. The work broadens the design path of s‐polarized TMOKE as a promising candidate to promote the development of novel magnetoplasmonic sensors and nonreciprocal photon devices.
Enhancing creep rupture life prediction of high‐temperature titanium alloys using convolutional neural networks
Authors: Zong Bangtan , Li Jinshan , Zhou Changlu , Wang Ping , Tang Bin , Yuan Ruihao 
Published: November 2024

AbstractPrediction of creep rupture life of high‐temperature titanium alloys is crucial for their practical applications. The efficient representations (features) of the information encoded in the data are essential to achieve an accurate prediction model. Here, using convolutional neural networks (CNN) enhanced features, we obtain largely improved prediction models for creep rupture life. Comparison of CNN‐based features with the original features in describing different samples reveals that the former, by assigning more individualized labels, outperforms the latter and underpins improved prediction models. This work suggests that beyond images, CNN is also suitable for numerical data to obtain enhanced features and surrogate models.
A 26.5–29.5‐GHz Current‐Reused Low Noise Amplifier With Optimized Gate Bias and Flat‐Gain Matching Techniques for 5G Communication
Authors: Wang Hao , Huang Tongde , Hu Ziyi , Cao Hanzhang , Jin Jin , Tao Hongqi , Wu Wen 
Published: November 2024

ABSTRACTThis paper presents a Ka‐band flat‐gain low‐noise amplifier (LNA) in 65‐nm CMOS technology. An optimized gate bias technique is utilized for comprehensive optimization among noise figure (NF), input 1 dB compression point (IP1dB), and power consumption. Then a current‐reused technique is used to further reduce power consumption, and an inductor is inserted in the current‐reused DC path to improve the circuit's common mode stability. The interstage and output magnetic‐coupled resonator (MCR) matching network with individual pole manipulation is optimized to achieve an enhanced gain flatness. From the measurement results, S21 of 14.8–15.5 dB is achieved from 26.5 to 29.5 GHz, with a gain ripple of 0.7 dB. Measured NF varies from 2.85 to 3.3 dB, with the lowest NF at 27.5 GHz. The measured IP1dB at 28 GHz has achieved as high as −12.5 dBm. The whole LNA consumes 6.8 mW under a 1‐V supply, achieving a high FoM of 25.31 Hz in dB (dBHz). The fabricated LNA occupies a core area of 0.1 mm2.
Value Co‐Creation in a Social Purpose Institution: The Case of the Dynamo Camp Art Factory—Between Art Therapy and Artification
Authors: Ostillio Maria Carmela , Carù Antonella 
Published: November 2024

ABSTRACTThis study explores artification in nonprofit organizations, specifically focusing on the use of the arts to enhance the well‐being of users. By examining how nonprofit institutions integrate artistic practices into their programs, the research highlights the potential for art to serve as a tool for promoting emotional, mental, and social well‐being among diverse populations. Moreover, the impact of art therapy on various stakeholders (e.g., artists and/or art dealers) within nonprofit health and social service organizations and the art market in general remains understudied. Therefore, this study examines the case of the Dynamo Camp Art Factory and the complex system of relationships between the various stakeholders to understand the benefits of art therapy and the related artification process. Our findings show that through the involvement of artists in art therapy, value co‐creation activities have a cultural and economic impact far beyond the therapeutic effect.
A Framework for Understanding the Impacts of Thaw‐Driven Disturbance Regimes on Northern Lakes
Authors: Thienpont Joshua R. , O'Hagan Claire , Kokelj Steven V. , Hoskin Grace N. , Pisaric Michael F. J. , Smol John P. , Stewart Emily , Korosi Jennifer B. 
Published: November 2024

ABSTRACTThe impacts of permafrost thaw do not manifest uniformly across the Arctic, and this presents challenges for predicting how permafrost‐affected lakes will respond to climate change. Here, we leveraged long‐term field data collection and studies of a particular permafrost lake type (predisposed to thaw slump disturbance) in the Tuktoyaktuk Coastlands region to develop a conceptual model that can shed light on, and facilitate further testing of, lake ecosystem impacts associated with polycyclic shoreline retrogressive thaw slumps. To inform the development of the model, we compared regional changes in slump activity and lake water quality variables known to be impacted by slumping between 2005 and 2017, and showed that the timeline to recovery in lake dissolved organic carbon (DOC) following slump stabilization was longer than the time between cycles of slump growth, stabilization, and re‐initiation in most lakes. We also analyzed geochemical changes in sediment cores that incorporated the last several hundred years of history in 18 lakes that spanned a gradient in thaw slump disturbance, as well as a core dating back to ca. 1365 CE in a lake with an ancient slump. Results indicate that sediment geochemical changes were most pronounced at the initial onset of slumping, with only muted changes in sediment characteristics upon slump growth or re‐initiation. Our conceptual model can guide future investigations into the extent to which lakes with polycyclic slumps are predisposed to, or buffered against, significant limnological changes under anthropogenic climate warming. While our model is specific to lake systems in ice‐cored morainal terrain impacted by retrogressive thaw slumping, similar approaches would be highly useful for understanding ecosystem response under a range of permafrost disturbance categories.
Guaranteed Disturbance Compensation and Robust Fault Detection Based on Zonotopic Evaluation
Authors: Fu Shui , Wang Rui , Tang Wentao , Sun Xi‐Ming 
Published: November 2024

ABSTRACTIn the context of model‐based fault detection, it is crucial to achieve strong robustness against disturbance and noise. However, the existing robust fault detection methods typically address disturbance and noise in a centralized manner to enhance robustness, which may cause some conservatism since the dynamic characteristics of disturbance and noise are considerably different. In addition, most of the existing model‐based fault detection method is implemented with constant thresholds, which may further introduce conservatism. In this context, this paper proposes a guaranteed disturbance compensation and robust fault detection method based on zonotopic evaluation for the discrete‐time systems subject to unknown but bounded disturbance and noise. To this end, a disturbance compensation controller is developed based on technology to obtain guaranteed control performance. Moreover, the control performances with or without disturbance compensation are analyzed based on zonotopes. By considering the disturbance dynamic characteristics, an extended fault detection observer (EFDO) is created to pursue robustness to disturbance, noise, and sensitivity to fault simultaneously. Meanwhile, a multi‐objective EFDO is devised by exploiting the index and index as the criteria within the finite‐frequency domain. Furthermore, the zonotopic residual evaluation is further deployed to generate the residual boundary, which helps to reduce the conservatism of fault detection. The superiority of the proposed method is theoretically analyzed. Simulation results also validate the effectiveness and superiority of the proposed method in disturbance compensation fault detection.
Synthesis, Antimicrobial, and Antioxidant Evaluation of Some New Thiazole‐Schiff Base Derivatives
Authors: Cenik Yıldız Atalay , Sarıgüney Ahmet Burak , Erci Fatih , Coşkun Ahmet 
Published: November 2024

AbstractIt is well known that antimicrobial resistance poses a major threat to human health worldwide. For this reason, it is important to obtain new compounds to combat microbial pathogens. Because of this, in this study, some thiazole‐Schiff base derivatives were synthesized, and characterized by spectroscopic techniques, and their antimicrobial and antioxidant properties evaluated. Antimicrobial activities were assessed using the broth microdilution method and expressed as a minimum inhibitory concentration against Staphylococcus aureus and Escherichia coli. From these compounds, compounds (8) and (9) demonstrated significant antimicrobial activity. Also, compound (5) showed the strongest antioxidant activity. According to us, the synthesis of new thiazole‐Schiff‐based molecules and evaluation of their antimicrobial effects are important in the development of new drugs.
BaTiO3/I@g‐C3N4 Z‐Scheme Heterojunctions With Superior Charge Transfer for Efficient Photocatalytic Antibiotic Wastewater Treatment
Authors: Kumar Amit , Sharma Pankaj , Wang Tongtong , Sharma Gaurav , Dhiman Pooja , Verma Akshay , Shi Hui 
Published: November 2024

AbstractExploring heterojunction formation between conjugated organic polymer and metal‐based semiconductors with promoted charge transfer and efficient spatial charge separation has proven to be quite successful in reinforcing photocatalytic wastewater treatment. Focusing on the removal of sulfonamide antibiotics from water, herein, we report BaTiO3/I@g‐C3N4 Z‐scheme heterojunction photocatalyst for degradation of sulfamethazine (SMZ) pollutant. The optimized heterojunction 25ICN/BT exhibits superior 94.5% removal of SMZ in 90 min, which is nearly 11 and 5 times faster than BT and pristine I@g‐C3N4 under visible light. The good repeatability of 25BT/ICN was proved by four‐cycle experiments. The remarkable improvement in photocatalytic activity was due to effective Z‐scheme transfer, diminished recombination, high charge transfer capacity, and redox capability. This was ascertained by electrochemical experiments and photoluminescence measurements. Furthermore, the degradation intermediates formed during the photocatalytic oxidation of SMZ were detected via liquid chromatography‐mass spectrometry, and a suitable degradation pathway was suggested. The heterojunctions showed excellent performance in river, lake, and tap water and for other antibiotic pollutants. The radical quenching experiments and band structure analysis inferred •O2− radicals as main active species. This work lays down new perspectives on hierarchical heterostructures for the superior removal of noxious antibiotic contaminants.
Synchronization of E. coli Bacteria Moving in Coupled Microwells
Authors: Japaridze Aleksandre , Struijk Victor , Swamy Kushal , Rosłoń Ireneusz , Shoshani Oriel , Dekker Cees , Alijani Farbod 
Published: November 2024

AbstractSynchronization plays a crucial role in the dynamics of living organisms. Uncovering the mechanism behind it requires an understanding of individual biological oscillators and the coupling forces between them. Here, a single‐cell assay is developed that studies rhythmic behavior in the motility of E. coli cells that can be mutually synchronized. Circular microcavities are used to isolate E. coli cells that swim along the cavity wall, resulting in self‐sustained oscillations. Connecting these cavities by microchannels yields synchronization patterns with phase slips. It is demonstrated that the coordinated movement observed in coupled E. coli oscillators follows mathematical rules of synchronization which is used to quantify the coupling strength. These findings advance the understanding of motility in confinement, and open up new opportunities for engineering networks of coupled oscillators in microbial active matter.
Engineering 2D Materials from Single‐Layer NbS2
Authors: Knispel Timo , Mohrenstecher Daniela , Speckmann Carsten , Safeer Affan , van Efferen Camiel , Boix Virgínia , Grüneis Alexander , Jolie Wouter , Preobrajenski Alexei , Knudsen Jan , Atodiresei Nicolae , Michely Thomas , Fischer Jeison 
Published: November 2024

AbstractStarting from a single layer of NbS2 grown on graphene by molecular beam epitaxy, the single unit cell thick 2D materials Nb5/3S3‐2D and Nb2S3‐2D are created using two different pathways. Either annealing under sulfur‐deficient conditions at progressively higher temperatures or deposition of increasing amounts of Nb at elevated temperature result in phase‐pure Nb5/3S3‐2D followed by Nb2S3‐2D. The materials are characterized by scanning tunneling microscopy, scanning tunneling spectroscopy, and X‐ray photoemission spectroscopy. The experimental assessment combined with systematic density functional theory calculations reveals their structure. The 2D materials are covalently bound without any van der Waals gap. Their stacking sequence and structure are at variance with expectations based on corresponding bulk materials highlighting the importance of surface and interface effects in structure formation.
Isolation, Synthesis, and Identification of Process‐Related Impurities From Morinidazole
Authors: Li Li , Dong Zongyue , Kong Xiangyu , Ma Yan , Yang Kehao , Xue Na , Hua Yuan , Qi Xiaolin , Han Chunhua , Zhang Kai 
Published: November 2024

ABSTRACTMorinidazole belongs to the category of third‐generation nitroimidazole antibacterial drugs. In the course of morinidazole production, the mother liquor from the recrystallization process was subjected to analysis for the identification and detection of eight process‐related impurities through high‐performance liquid chromatography (HPLC). The eight impurities (Imp‐A, Imp‐B, Imp‐C, Imp‐D, Imp‐E, Imp‐F, Imp‐G, and Imp‐H) included three new impurities (Imp‐A, Imp‐B, and Imp‐C) that were previously unreported and one potential genotoxic impurity (Imp‐H). Purity separation from the recrystallization mother liquor was carried out using preparative HPLC. To characterize these eight process‐related impurities, high‐resolution mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy were utilized, followed by direct synthesis. The retention times of the impurities were confirmed through co‐injection via HPLC. Additionally, Imp‐B, Imp‐C, and Imp‐G were detected in commercial morinidazole products. A detailed discussion was conducted on the possible pathways leading to the formation of these impurities. Furthermore, the toxicities of these compounds were predicted using ADMET/PK property prediction software based on artificial intelligence algorithm—ADMET Predictor. These results will provide technical support for the quality control of morinidazole.
Experimental investigation on the effect of natural fire exposure on the post‐fire behavior of reinforced concrete beams using electric radiant panel
Authors: Jovanović Balša , Caspeele Robby , Reynders Edwin , Lombaert Geert , Put Florian , Lucherini Andrea , Van Coile Ruben 
Published: November 2024

AbstractIn this study, the effects of natural fire exposure on the post‐fire behavior of concrete beams are investigated. The study is based on laboratory tests where three reinforced concrete beams were subjected to fire exposure using an electric radiant panel. This panel enables a precise application of radiative heat exposure closely mimicking natural fire exposure in a safe manner. During the test, the deflections, deformations and temperature changes are measured for all three concrete beams. Additionally, finite element modeling (FEM) is applied to supplement these tests, demonstrating the performance of existing structural fire engineering calculation tools in evaluating the burnout performance of concrete beams. The results of the tests show that the electric radiant panel provide a novel approach for fire simulation which is effective in replicating natural fire conditions, by applying the heat flux as specified in the Eurocode Parametric Fire Curve in a highly controlled manner. The uniformity of the temperature field measured inside the beams and the consistent deformations observed during the heat exposure across all three tests underscores the accuracy of the fire simulation. Furthermore, post‐fire assessments reveal that while the exposed beams suffered some reduction in load‐bearing capacity, they retained a significant portion of their original strength that was consistent across all three beams. The numerical simulations conducted in this study demonstrate a high level of accuracy in predicting the behavior of the concrete beams during fire exposure. These simulations effectively mirrored the experimental results, validating that they are a valuable tool for assessing concrete structures' performance in fire scenarios.
Microwave Shock Synthesis of Porous 2D Non‐Layered Transition Metal Carbides for Efficient Hydrogen Evolution
Authors: Fan Miao , Tian Haoran , Wu Zhiao , Dai Jiao , Ma Xiaorui , You Yongfei , Huang Jingru , Feng Yutong , Ding Wanting , Jiang Huiyu , Xu Weilin , Jin Huanyu , Wan Jun 
Published: November 2024

ABSTRACTTransition metal carbides (TMCs) serve as efficient catalysts for electrocatalytic hydrogen evolution reactions (HERs), holding significant importance in promoting hydrogen production for carbon neutrality. To optimize interfacial catalytic activity, structurally designing TMCs into two‐dimensional (2D) and porous structures to expose more practical surface areas and enhance electronic configurations is a common and effective strategy. Particularly, porous 2D non‐layered TMCs (2D NL‐TMCs) demonstrate richer active sites distinct from layered interfacial inertness. However, mainstream selective etching and chemical deposition growth mechanisms struggle to prepare highly active porous 2D NL‐TMCs due to constraints posed by their high structural strength and formation temperature. Herein, we successfully synthesized porous 2D W2C (2D p‐W2C) rapidly using a microwave shock method. Mechanistic verification reveals that leveraging transient high temperature and rapid on‐off properties of microwave effectively combines with an oxidation‐induced porosity mechanism, facilitating the evolution of porous 2D structures. These low‐dimensional nanostructures with abundant edge defect sites aid in efficient adsorption reactions of intermediate species in HER. Moreover, the successful preparation of a series of porous 2D NL‐TMCs (Mo2C, NbC, TaC) confirms the universality of this method, with the synthesized 2D p‐W2C exhibiting optimal HER performance. This strategy offers new insights into the topological synthesis of porous 2D NL crystals.