bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digitalization of Test-Rigs for Development of Hydraulic Machines: Predictive Model For Detection of Characteristics of Turbine and Pump-Turbine Models for Hydraulic Test-Rig Automation
Authors: Reiterer Stefan H. , Stolz Michael C. , Dikic Berin , Reiterer Daniel R. , Rossmann Bernhard , Schaffernak Gerhard , Guggenberger Mark 
Published: December 2024

Abstract
As part of the model acceptance testing according to IEC 60193:2019, it is required to determine the main hydraulic performance guarantee points. This usually involves extensive expert knowledge and is time consuming. To lessen the burden of testing engineers and reduce shifts, new automation strategies are needed. One of these strategies involves creating a system that replicates the tedious task of operators analyzing the machine’s characteristics manually and allows them to supervise the test procedure more efficiently. However, this provides us with new challenges as such systems have to rely on the provided data instead of longstanding experience, and although there is prior knowledge available from former tests regarding the behavior of the hydraulic, the prediction from prior models is based on hydraulic similarity and can only give a rough estimation. To detect areas of the characteristic points automatically, we present an approach consisting of predictive models and mathematical criteria to minimize the search region. We propose to use data from pre-measurements that are recorded quickly but do not adhere to the IEC norm. Nevertheless, the acquired data can be leveraged to build mathematical models with statistical methods on which search criteria can be applied. Several examples with real life data are demonstrated to validate the method. Additionally, automation requisites like starting and stopping are discussed.
Prevalence and clinical significance of Claudin-3 expression in cancer: a tissue microarray study on 14,966 tumor samples
Authors: Büyücek Seyma , Schraps Nina , Menz Anne , Lutz Florian , Chirico Viktoria , Viehweger Florian , Dum David , Schlichter Ria , Hinsch Andrea , Fraune Christoph , Bernreuther Christian , Kluth Martina , Hube-Magg Claudia , Möller Katharina , Reiswich Viktor , Luebke Andreas M. , Lebok Patrick , Weidemann Sören , Sauter Guido , Lennartz Maximilian , Jacobsen Frank , Clauditz Till S. , Marx Andreas H. , Simon Ronald , Steurer Stefan , Burandt Eike , Gorbokon Natalia , Minner Sarah , Krech Till , Freytag Morton 
Published: December 2024

Abstract
Background
Claudin-3 (CLDN3) participates in the formation of the tight-junctions (TJs) that regulate intercellular permeability. Altered CLDN3 expression has been linked to tumor progression in multiple tumor types. Despite its widespread expression in normal epithelial cells, CLDN3 is considered an attractive drug target candidate, since it may be more accessible in cancer cells than in normal cells due to their less orchestrated cell growth.

Methods
To comprehensively determine the prevalence of CLDN3 expression in cancer, a tissue microarray containing 14,966 samples from 133 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry.

Results
CLDN3 immunostaining was observed in 8,479 (68.9%) of 12,314 analyzable tumors, including 11.6% with weak, 6.2% with moderate, and 51.1% with strong positivity. CLDN3 staining was found in 96 of 133 tumor categories, 80 of which contained at least one strongly positive case. CLDN3 positivity was most seen in neuroendocrine neoplasms (92–100%) and in adenocarcinomas (67–100%), tumors of the female genital tract, including various subtypes of ovarian and endometrial carcinoma (up to 100%), as well as different subtypes of breast cancer (95.3–100%). CLDN3 positivity was less common in squamous cell carcinomas (0–43.2%) and mainly absent in melanoma, mesenchymal, and hematolymphatic neoplasms. In clear cell renal cell carcinoma (ccRCC), low CLDN3 was strongly linked to poor ISUP (p < 0.0001), Fuhrman (p < 0.0001), and Thoenes (p < 0.0001) grades, advanced pT category (p < 0.0001), high UICC stage (p = 0.0006) and distant metastasis (p = 0.0011), as well as shortened overall (p = 0.0118) and recurrence-free (p < 0.0001) survival. In papillary RCC (pRCC), low CLDN3 was associated with poor grade (p < 0.05), high pT (p = 0.0273) and distant metastasis (p = 0.0357). In urothelial carcinoma high CLDN3 was linked to high grade (p < 0.0001) and nodal metastasis (p = 0.0111). The level of CLDN3 staining was unrelated to parameters of tumor aggressiveness in pancreatic, gastric, and breast cancer.

Conclusion
In conclusion, our data demonstrate significant levels of CLDN3 expression in many different tumor entities and identify reduced CLDN3 expression as a potential prognostic marker in RCC.
Nonhepatic Hyperammonemic Encephalopathy: An Unmasked Urea Cycle Disorder in the Setting of Late Gastric Bypass Complication
Authors: Zeghlache Rached , Samardzic Tijana , Norman Katelyn 
Published: December 2024

ABSTRACT
We present the case of a woman with nonhepatic hyperammonemic encephalopathy, a rare complication of bariatric surgery. Proposed mechanism include underlying urea cycle disorders and increased ammonia production. Clinically, states of hyperammonemia present with predominantly neurological symptoms of behavioral disturbances, lethargy, seizures, and coma. Given the high morbidity and mortality rate of nearly 40%, early recognition and treatment of the underlying mechanisms of hyperammonemia are crucial.
Benchmarking the efficiency of distribution warehouses using a four-phase integrated PCA-DEA-improved fuzzy SWARA-CoCoSo model for sustainable distribution
Authors: Song Meijing , Andrejić Milan , Pajić Vukašin , Chatterjee Prasenjit , Ma’arof Muhammad Izzat Nor 
Published: December 2024

Abstract
In a dynamic market marked by disruptions like pandemics and recessions, organizations face significant challenges in efficiently managing logistics processes and activities. The primary objective of this article is to propose an integrated four-phase model for assessing the efficiency of retail distribution warehouses based on principal component analysis-data envelopment analysis-improved fuzzy step-wise weight assessment ratio analysis-combined compromise solution (PCA-DEA-IMF SWARA-CoCoSo). The model provides a synergistic effect of all positive sides of the considered methods. PCA-DEA methods are used to reduce the number of variables and to identify efficient warehouses. IMF SWARA is applied to determine criteria weights, while the CoCoSo method is employed in the last phase for ranking efficient warehouses. The model incorporates 18 inputs and 3 outputs, derived from both literature and real-world systems. The proposed model identifies the most efficient warehouses, which can serve as benchmarks for improving the performance of less efficient ones. After implementing PCA-DEA, only seven warehouses were identified as efficient. Subsequently, fixed and variable costs are identified as the two most important criteria. Results of the considered case study indicate that warehouse A4 emerges as the best one, whereas A6 is the least preferred warehouse. This research offers valuable insights and practical implications for organizations operating in dynamic markets, assisting them in achieving operational excellence and improving their supply chain performance.
Studies on the Iconography and Interpretation of Combat Scenes of the Late Bronze Age Aegean: A re-appraisal
Authors: Galanis Panagiotis 
Published: December 2024

Abstract
The iconographic depictions of combat scenes in the art of the Late Bronze Age Aegean constitute the most fascinating motives of their era. These representations of fighting astonish us by their diversity. They have been immortalised on heterogeneous kinds of material, throughout the Late Bronze Age.
The aim of this paper is to present and examine the issues of iconography of these performances. To do so, I use a typological method based on thematic, chronological, material and contextual criteria. Questions, such as whether these representations refer to mythical-fictional or historical-real events, will be addressed. In addition, questions arises as to what extent these combat scenes were a common topic of the Aegean Bronze Age art and during which chronological periods they occurred. Questions about the importance of such motifs in the society of that period, as well as whether they were products of either Minoan or Mycenaean workshops and if it is possible to recognize different artistic tendencies, are also examined.
The analysis of the data shows that it is possible, at least for the early phase of the Late Bronze Age, to distinguish between artistic styles. It also shows that every combat scene of the Late Bronze Age Aegean could have a manifold significance for the society of that era, above all because the symbolic meaning of the struggle was integrated into the practical occurrence of war.
Leitor, leitura e a representação da intelectualidade feminina na literatura: de África à América Ladina
Authors: Lima Santos Denilson 
Published: December 2024

A literatura permite estabelecer diálogos múltiplos e, nesse contexto, o presente ensaio apresenta as autoras Isabel Ferreira (Angola), Conceição Evaristo (Brasil), Amalia Lú Posso Figueroa (Colômbia) e María Nsué Angüe (Guiné Equatorial) como exemplos de mulheres escritoras que elaboram narrativas em que se pode refletir sobre três categorias, a saber, o leitor, a leitura e a formação do leitor, no processo criativo textual e no espaço da intelectualidade feminina africana e afro-latino-americana. Para isso, lança-se mão da literatura comparada como método de investigação com o objetivo de compreender o texto em uma perspectiva ampla e capaz de formar outras epistemologias e estéticas. Faz-se necessário entender e visibilizar outras vozes e letras no cenário da arte escrita. Assim, podemos dizer que as escritoras se inserem na discussão da tradição da palavra prenhe de saberes africanos e diaspóricos presentes nos contos e romances.
Fauna Šiaulių dvare XVII–XVIII a. pagal zooarcheologinius ir istorinius duomenis
Authors: Jonauskienė Viktorija , Ostašenkovienė Virginija 
Published: December 2024

Since 1589, Šiauliai became the center of Šiauliai Crown Estate, which maintained the ruler’s estate. From the 17th century onwards, Šiauliai Crown Estate was constantly entrusted to manage by loans to nobles of the Grand Dutchy of Lithuania, with its administrators changing over time (from 1678 to 1696, it belonged to King John III Sobieski). Šiauliai Crown Estate was administered by their appointed administration: an economist, vice-economist, and local officials. Officials of the manor administration were assisted by provision clerks, scribes, and other staff. The residence of the administration became Šiauliai Manor.
The first small-scale archaeological investigations in the residential estate of Šiauliai Manor were carried out in 1997 (led by Audronė Šapaitė). More extensive archaeological excavations were conducted at the manor between 2010 and 2022. During this period, a total area of 533 square meters was excavated, and 10,577 square meters were surveyed. The remains of 11 structures dating from the 17th century to the early 20th century were localized within the territory of Šiauliai Manor, and 8,286 archaeological artifacts were collected along with abundant zooarchaeological material.
In total, 1,114 fragments of zooarchaeological material dating from the 17th to the 18th centuries were collected and analyzed from archaeological cultural layers of the manor. The studied material provides an overview of the distribution of domestic (85 %) and wild (15 %) fauna in the zooarchaeological material of Šiauliai Manor. The surviving material allows insights into prevailing trends such as differences in the quantities of domestic and wild fauna, and to some extent, the presence of domestic animals in the manor, as well as the consumption of luxury goods and reflections of Western culture in Šiauliai Manor. The inventories of Šiauliai economy and the obtained statistical analysis provide an opportunity to gain a more comprehensive understanding of the daily life of the ruler’s table in Šiauliai Manor during the 17th–18th centuries and to extract the maximum information from the available/remaining data.
Development of a composite material based on Al2O3 for use in waste combustion plants
Authors: Lyulyukin A. P. , Dubinin Y. V. , Kukushkin R. G. , Yakovlev V. A. 
Published: December 2024

Catalytic fluidized bed combustion is the most environmentally friendly and energy efficient way of processing various fuels, including low-grade ones. The technology involves the oxidation of volatile substances on the surface of catalyst particles diluted with an inert material in a fluidized bed. The traditional use of quartz sand as an inert material leads to accelerated destruction of the catalyst during operation by attrition. The work is devoted to the study of the effect of magnesium modification of spherical γ-Al2O3, used as a carrier for a deep oxidation catalyst (DOC) in a fluidized bed, and the development of an inert material capable of minimizing DOC losses. The modified carrier was obtained by impregnating spherical γ-Al2O3 granules with a Mg-containing precursor solution (nitrate and acetate) followed by calcination of granules at 800 °C. The obtained granules were studied by X-ray fluorescence analysis (XRF), inductively coupled plasma optical emission spectroscopy (ICP-OES), low-temperature nitrogen adsorption (BET), scanning electron microscopy (SEM). Their mechanical strength and catalytic activity in CO oxidation were also determined. A linear increase in the strength characteristics of γ-Al2O3 was found with the introduction of magnesium from 2 to 9 wt. %. In laboratory conditions, the use of the selected material made it possible to reduce the loss of the catalyst at 4.5 -hour attrition test by 3 times compared with quartz sand.
ISRAELI EMPIRE AND END-TIMES
Authors: Eliansyah Ivan 
Published: December 2024

Since the founding of the state of Israel there has been a series of prolonged conflicts between Israel and the surrounding Arab countries, and especially Palestine. The entire global community was shocked by the issue of the bombardment of women and children in Gaza and Rafah. Amid the chaos of the Western subjectivity lobby and the silence of several influential muslim leaders and the UN, the Islamic and non-Islamic world needs to understand the future roots of Israel’s mysterious agenda through ta’wīl and predictive analysis of Islamic Eschatology initiated by Imran Nazar Hosein. This article examines Israel’s agenda by studying the chronological eschatological concept of “Three Paxes” especially “Pax Judaica” using analytical-descriptive methods. In this qualitative research, researchers used library research by collecting data from several references such as main reference books, journals, videos, and others. According to the findings in this article, in Islamic Eschatology; the agenda is three stages starting in Great Britain (Pax Britannica) then in the US (Pax Americana), and moving on to Israel (Pax Judaica) before finally, the Antichrist appears to take over the throne of King Solomon in Jerusalem. Finally, the conclusion of Israel’s agenda from Imran Hosein’s allegorical interpretation is none other than to prepare a false Jesus (al-Dajjāl) after his systems (control of usury and the monetary system, politics, the emergence of Gog and Magog and biggest war) begin to be fulfilled.
Assessment of changes in leaf biochemical constituents of palas (Butea monosperma) during different stages of lac insect (Kerria lacca Kerr) life cycle
Authors: Lohot Vaibhav , Thamilarasi K , Ghosh J. , Mohansundaram A. , Thakur Vishwa V. 
Published: December 2024

Abstract

Lac insect (Kerria lacca Kerr) is an important source of natural lac resin. Its cultivation has been strengthening the economy of farmers who depends on the forest resources for their livelihood. Palas (Butea monosperma) is a major host plant for lac insect cultivation. Being a phloem sap feeder, lac insect exerts stress on the host plant; therefore, to cope up with stress host plant undergoes a variety of biochemical and physiological changes. The present study was attempted to analyze the important biochemical changes in the host plant palas during different stages of rangeeni lac insect life cycle (baisakhi summer crop). The study revealed that lowest level of total sugar, soluble protein, free phenol and proline were found after lac insect mating stage (fertilization). The period after lac insect mating till maturity is critical period due to high demand of phloem sap for lac insect development. Therefore, it is necessary to maintain nutritional demands of host plants at critical period of lac insect development for achieving high lac production.
Feasibility and acceptability of a contextualized brief Psychological Intervention for people with bipolar disorder in rural Ethiopia
Authors: Demissie Mekdes , Hanlon Charlotte , Ng Lauren , Mayston Rosie , Fekadu Abebaw 
Published: December 2024

Abstract

Background: There is a huge unmet need for appropriate psychological interventions for bipolar disorder for use in low-and middle-income countries. We developed a Psychological Intervention for BD in Ethiopia using the Medical Research Council’s framework for the Development and Evaluation of Complex Interventions in a primary health care setting in Ethiopia. The aim of this study is to investigate the feasibility, acceptability and fidelity of this newly developed psychological intervention for BD in a PHC setting in south-central Ethiopia.
Method. A total of 12 euthymic people with bipolar disorder and five caregivers participated in five 20-minute weekly sessions of the psychosocial intervention. We used a mixed-method evaluation, including in-depth qualitative interviews, fidelity ratings of a random selection of 25% of the audio recorded intervention sessions, and self-reported change in symptom severity. We used thematic analysis for qualitative data and descriptive analysis for quantitative data.
Results: Except for one caregiver, all participants completed all five-sessions. Intervention providers and recipients expressed satisfaction with the intervention. Intervention providers confirmed that the intervention can be provided in the primary health care setting, although 20-minutes was considered insufficient. While participants acknowledged the importance of involving caregivers in the intervention, they raised privacy concerns. Intervention providers’ adherence to the manual was moderate. Preliminary findings indicate a reduction in depressive symptoms post-intervention and improvement in providers’ perceived knowledge and skills.
Conclusions: This contextually developed psychological intervention for bipolar disorder has promising feasibility, acceptability and potential utility. Further studies should evaluate time considerations and effectiveness.
Trial registration: the trial was registered on 16 August 2024, retrospectively on the Pan African Clinical Trial Registry database [PACTR202408896160144],
https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=31727
Formation permeability estimation using mud loss data by deep learning
Authors: Abdollahfard Yaser , Mirabbasi Seyed Morteza , Ahmadi Mohammad , Ashoorian Sefatallah , Hemmati-Sarapardeh Abdolhossein 
Published: December 2024

Abstract

Permeability estimation plays an essential role in the assessment of reservoirs and hydrocarbon extraction. There are various methods to evaluate the formation and estimate the formation permeability, but in some cases, the evaluation may not be done or it may not be done correctly. This study focuses on a novel method to estimate the formation's permeability with appropriate accuracy using the mud loss data. Machine learning applications are becoming more popular nowadays and can succeed in many fields. This current research focuses on the application of mud loss data and deep learning to estimate the formation's permeability. To implement and validate our methodology, it is considered pilot cases including reservoir and drilling parameters values (depth, formation type, formation thickness, mud density, mud viscosity, and formation permeability). It is assumed that mud loss was occurred because of deferential pressure between formation pressure and bottom-hole pressure. The mud loss rate data were generated at different sets of reservoir and drilling data values using a reservoir simulator and then evaluated by calculating the correlation coefficients to ensure their validity and to check the fit under real conditions. This can be used to estimate the formation permeability values. One-dimensional convolutional neural networks(1D-CNN), a type of convolutional neural network, is utilized to be trained with data to perform a regression problem based on the contribution of flattening, dropout, and fully connected layers to estimate permeability with high accuracy (training data R2= 0.970, testing data R2= 0.964). Then the new deep learning method, Deep jointly informed neural network (DJINN), with the cooperation of neural networks and decision trees, provides a more accurate model than 1D-CNN (training data R2= 0.978, testing data R2= 0.972). These descriptions may provide new applications for mud loss data, where data while drilling can be used to predict formation permeability and provide insights for petroleum engineers to accurately measure design.
Single-cell analysis reveals that GFAP+ dedifferentiated Schwann cells promote tumor progress in PNI-positive distal cholangiocarcinoma via lactate/HMGB1 axis
Authors: Zhai Wenlong , Zu Ziyang , Zhang Chong , Shi Jianxiang , Chen Kunlun , Tang Hongwei , Hu Kaizhao , Liu Enchi , Ji Chengyang , Feng Ruo , Shi Xiaojing 
Published: December 2024

Abstract

Distal cholangiocarcinoma (dCCA) is a highly lethal malignancy that accounts for approximately 40% of patients with primary cholangiocarcinoma. Remarkable cellular heterogeneity and perineural invasion (PNI) are two typical features of dCCA. Deciphering the complex interplay between neoplastic and neural cells is crucial for understanding the mechanisms propelling PNI-positive dCCA progression. Herein, we conduct single-cell RNA sequencing on 24 715 cells from two pairs of PNI-positive dCCA tumors and adjacent tissues, identifying eight unique cell types. Malignant cells exhibit significant inter- and intra-tumor heterogeneity. We delineate the compositional and functional phenotypes of five Schwann cell (SC) subsets in PNI-positive dCCA. Moreover, our analyses reveal two potential cell subtypes critical to forming PNI: NEAT1+ malignant cells characterized by hypoxia and GFAP+ dedifferentiated SCs featuring hypermetabolism. Further bioinformatics uncover extensive cellular interactions between these two subpopulations. Functional experiments confirm that lactate in the hypoxic tumor microenvironment can induce GFAP-dedifferentiation in SCs, which promotes cancer cell invasion and progression through upregulating HMGB1. Taken together, our findings offer a thorough characterization of the transcriptional profile in PNI-positive dCCA and unveil potential therapeutic targets of dCCA PNI.