bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enantioselective Bromolactonization of Trisubstituted Olefinic Acids Catalyzed by Chiral Pyridyl Phosphoramides
Authors: Nishikawa Yasuhiro , Hamamoto Yuhta , Satoh Rika , Akada Naho , Kajita Shuhei , Nomoto Marina , Miyata Megumi , Nakamura Madoka , Matsubara Chinatsu , Hara Osamu 
Published: September 2018

AbstractEnantioselective bromolactonization of trisubstituted olefinic acids producing synthetically useful chiral lactones with two contiguous asymmetric centers has remained mainly unexplored except for the 6‐exo cyclization mode. In this work, the 5‐exo‐ and 6‐endo modes of bromocyclization of trisubstituted olefinic acids were enabled for the first time using N‐bromosuccinimide and a pyridyl phosphoramide catalyst. The utility of the resulting bromolactones was demonstrated by transformations harnessing reactive alkyl bromide moieties without losing stereochemical information. Optimization studies and control experiments revealed that the basicity of pyridine moieties and presence of N−H protons in the phosphoramide species strongly affected both the reactivity and enantioselectivity parameters.
Borane‐Catalyzed Synthesis of Quinolines Bearing Tetrasubstituted Stereocenters by Hydride Abstraction‐Induced Electrocyclization
Authors: Maier Alexander F. G. , Tussing Sebastian , Zhu Hui , Wicker Garrit , Tzvetkova Pavleta , Flörke Ulrich , Daniliuc Constantin G. , Grimme Stefan , Paradies Jan 
Published: September 2018

AbstractThe borane‐catalyzed synthesis of quinoline derivatives bearing tetrasubstituted stereocenters from vinyl anilines has been developed. Mechanistic studies and quantum‐mechanical investigations support the hydride abstraction/electrocyclization/hydride addition mechanism. The products were obtained in up to 99 % yield with a diastereoselectivity of >99 % in favour for the 3a‐5‐cis isomer.
Chiral recognition of the carnitine enantiomers using rhodamine B as a resonance Rayleigh scattering probe
Authors: Yang Jidong , Tan Xuanping , Zhao Yanmei 
Published: September 2018

AbstractA novel and simple method for simultaneous determination of chiral carnitine (CA) enantiomers was proposed. In this work, the rhodamine B (RhB) could react with D‐CA and L‐CA, and new resonance Rayleigh scattering (RRS) peaks were generated. According to the polarization experiments, it could be testified that scattering peak of this system was composed of resonance fluorescence and scattering light. The RRS intensity of the RhB could be enhanced with the addition of D‐ or L‐CA. However, The RRS signal with L‐CA had greater degree increased. So a useful assay program for the selective and simultaneous determination of CA enantiomers was built via the RRS signal differences of the two CA enantiomers responding to RhB. The results showing a good linear relationship and high correlation coefficient were obtained, and the detection limit was calculated as 0.086 μg·mL−1 (D‐CA) and 0.042 μg·mL−1 (CA). Here, new built RRS method with RhB as chiral probe could be applied to achieve selective analysis through this work. The applicability of the chiral recognition of CA enantiomers mixtures in samples had been demonstrated by its low cost, sensitivity, enantioselectivity, simplicity, and good availability of the materials.
Use of a low‐cost telecytopathology method for remote assessment of thyroid FNAs
Authors: Costa Camilla , Pastorello Ricardo Garcia , Mendonça André , Tamaro Caroline , Morais Caroline , Barbosa Barbara , Ribeiro Karina Braga , Caivano Alessandra , Saieg Mauro Ajaj 
Published: September 2018

BackgroundRapid on‐site evaluation is a great tool for optimizing the adequacy and quality of cytologic samples. The objective of the current study was to analyze a low‐cost telecytopathology method for the remote assessment of thyroid fine‐needle aspiration biopsies (FNABs), with comparison of the primarily rendered adequacy and diagnosis with the final conventional analysis.MethodsMaterial collected from thyroid FNABs was immediately smeared onto glass slides and stained with Diff‐Quik. A conventional microscope attached to a smart device was operated on‐site by either a medical student or a pathology resident for Wi‐Fi transmission of the images by Skype. The cytopathologist would remotely guide the screening of the slides, zooming in and out of areas of interest. Remote assessment included an analysis of material adequacy and a preliminary diagnosis. The quality of the transmission and the number of slides also were recorded. After a washout period of 3 weeks, final diagnosis and adequacy were assigned by conventional microscopy.ResultsThe final agreement rate for adequacy between remote and conventional analysis was 90.5%. For diagnosis, the final agreement rate was 83.3%. The diagnosis agreement rate varied, depending on the quality of transmission: there was 88% agreement when the quality was excellent, 77.8% agreement when it was good, and 62.5% agreement when it was poor.ConclusionsLow‐cost telecytopathology is an efficient method for the remote assessment of thyroid FNAB adequacy and diagnosis. The wide use of such technology in low‐resource or remote centers may have a positive impact on the number of adequate or satisfactory samples, optimizing the management of patients who have thyroid nodules.
Effect of a High‐Fat Meal on the Pharmacokinetics of the HIV Integrase Inhibitor Cabotegravir
Authors: Patel Parul , Ford Susan L. , Lou Yu , Bakshi Kalpana , Tenorio Allan R. , Zhang Zhiping , Pan Rennan , Spreen William 
Published: September 2018

AbstractCabotegravir is an integrase inhibitor in clinical development for the treatment and prevention of HIV infection using oral tablets for short‐term, lead‐in use before subsequent administration of a long‐acting injectable formulation. This phase 1, single‐center, randomized, 2 × 2 crossover study evaluated the effect of a high‐fat meal on the pharmacokinetics (PK) of oral cabotegravir. Healthy adults received oral cabotegravir 30 mg as a single dose on 2 separate occasions, either after fasting or following a high‐fat meal (∼53% fat, ∼870 kcal). Safety evaluations and serial PK samples were collected, and a mixed‐effects model was used to determine within‐participant treatment comparison of noncompartmental PK parameters. Twenty‐four patients were enrolled and had a mean body mass index of 25.6 kg/m2; 67% were male. Compared with the fasting state, coadministration of cabotegravir with a high‐fat meal increased plasma cabotegravir area under the concentration‐time curve and maximal drug concentration, each by 14%. The slight 14% to 17% increase in exposure associated with a high‐fat, high‐calorie meal was not considered clinically significant. No grade 3/4 adverse events (AEs), drug‐related AEs, or AEs leading to discontinuation were reported.
Effective Green Alliances: An analysis of how environmental nongovernmental organizations affect corporate sustainability programs
Authors: Lee Maggie Ka Ka 
Published: September 2018

AbstractWhile corporate sustainability is attaining more spotlight, the role environmental nongovernmental organizations (ENGOs) play in corporate sustainability programs (CSPs) continues to be ambivalent. Some ENGOs take on policing roles towards CSPs, whereas others form “Green Alliances” with corporations to enhance their CSPs. This paper takes a deep dive into CSPs, ENGOs, and communication problems associated with CSPs, namely, reporting inadequacies and greenwashing. Potential angles from which ENGOs can help foster or enhance corporate sustainability are then identified and examined.This empirical study examines several factors to improve corporate sustainability through partnerships with ENGOs. From the survey results, the top areas in which ENGOs can influence CSPs are determined—these include external value creation and the identification and monitoring of corporate negative environmental impact. There is evidence found in support of a correlation between trust in ENGOs and the perceived effectiveness of Green Alliances.
Determinants of the implementation of environmental risk indicators: Empirical evidence from the Italian manufacturing context
Authors: Lamboglia Rita , Paolone Francesco , Mancini Daniela 
Published: September 2018

AbstractThis study analyzes the factors associated with the implementation of environmental risk indicators (ERIs) among organizations. According to studies that show the relevance of management accounting tools for managing risk, we measure the level of ERI implementation across organizations by analyzing the presence of environmental performance indicators in corporate social responsibility reports and on corporate web sites. The analysis is based on data gathered from 72 Italian listed manufacturing companies for the year 2015. The empirical findings suggest that ERI implementation is positively driven primarily by the following variables: the presence of a chief risk officer, the level of environmental risk score, and firm complexity. In contrast, the number of independent directors on the board does not affect ERI implementation.
A low‐power CMOS transimpedance amplifier in 90‐nm technology for 5‐Gbps optical communication applications
Authors: Zohoori Soorena , Dolatshahi Mehdi 
Published: September 2018

SummaryIn this paper, a modified Regulated Cascode (RGC)‐based, low‐power, transimpedance amplifier (TIA) is proposed followed by a closed‐loop gain stage beside an added level shifter circuit to the booster of a conventional RGC circuit to set the proper biasing conditions for the transistors in the proposed TIA structure in 90‐nm CMOS technology. Moreover, the added gain stage benefits from an active inductor which resonates with the output capacitance of the TIA circuit to extend the bandwidth while saves the occupied chip area in comparison with passive inductor schemes. In addition, the performance of the proposed TIA circuit is simulated in HSPICE using 90‐nm CMOS technology parameters which show a transimpedance gain of 41 dBΩ, −3‐dB frequency bandwidth of 3.7 GHz, input referred noise value of 834nArms, and the power consumption value of only 1.4 mW at 1‐V supply.
Ageing patients in forensic psychiatric settings: A review of the literature
Authors: Di Lorito Claudio , Vӧllm Birgit , Dening Tom 
Published: September 2018

ObjectivesThe prevalence of ageing patients in forensic psychiatric settings is increasing. However, limited research has reported around this population. The aim of this scoping review is to synthesise the current evidence around ageing forensic psychiatric patients.MethodsThe literature was searched through four databases and Google searches. The identified outputs were screened for suitability and assessed for quality. Quantitative data were extracted and analysed on SPSS; qualitative data were extracted and analysed onto NVivo.ResultsSeven studies were included in the review. Quantitative results reported around demographics, service contact, offending patterns, mental, and physical health of ageing patients. Qualitative findings focused on age‐friendliness of services, staff‐patient rapport, activities, security issues, and discharge planning.ConclusionsAgeing forensic psychiatric patients present with complex and unique needs in relation to treatment, activities, mental, physical, and support. Further research looking at individual patients' needs is paramount to inform policy development and good practice in this area.
From Metal‐Metal Bonding to Supra‐Metal‐Metal Bonding Directed Self‐Assembly: Supramolecular Architectures of Group 10 and 11 Metals with Ligands from Mono‐ to Poly‐Pyrazoles
Authors: Yu Shu‐Yan , Lu Hong‐Lin 
Published: September 2018

AbstractThe supramolecular architectures of pyrazole ligands with polynuclear metal centers have established a wide variety of constructing motifs. This review focuses on the metal‐metal bonding and Supra‐Metal‐Metal Bonding directed self‐assembly of supramolecular architectures of pyrazole ligands ranging from simple mono‐pyrazoles and derivatives to bipyrazoles and polypyrazoles with group 10 and 11 elements. The utility of the constructing motifs (μ‐pyrazolato‐N,N′)2 doubly‐bridged dimetal corners in the metal‐metal‐bonding directed self‐assembly approaches with spontaneous deprotonation from bipyrazole to tripyrazole and tetrapyrazolyl calix[4]arene ligands, metallomacrocyclic and cage‐like complexes have been synthesized. The proton switching programmable self‐assembly strategy using pyrazole‐based bifunctional ligands has been developed by Yu. They have obtained organic homo‐ or hetero‐metallic supramolecular complexes from macrocycles, cages, to one dimensional polymers.
Prevalence and risk factors for urinary tract infection following stress urinary incontinence surgery with two midurethral sling procedures
Authors: Paz‐Levy Dorit , Weintraub Adi Y. , Reuven Yonatan , Yohay Zehava , Idan Inbal , Elharar Debi , Yohay David 
Published: September 2018

AbstractObjectiveTo compare prevalence and risk factors for urinary tract infection (UTI) following midurethral sling surgery with either the GYNECARE ABBREVO Continence System (Ethicon, Somerville, NJ, USA) or a standard transobturator.MethodsA retrospective cohort study was conducted among women who underwent midurethral sling surgery to treat stress urinary incontinence at a single tertiary hospital in Israel between January 1, 2014, and August 11, 2015. Data were retrieved from medical records. The diagnosis of UTI was based on a positive urine culture result.ResultsOf 178 patients included, 30 (16.9%) underwent the ABBREVO procedure and 148 (83.1%) underwent the standard transobturator procedure. The mean ± SD BMI at the time of surgery was 28.1 ± 4.5 for the standard transobturator procedures and 30.7 ± 15.2 for the ABBREVO procedures. Women who underwent the ABBREVO procedure had an increased duration of hospitalization (P=0.004), and higher rates of concomitant anterior colporrhaphy procedures (P=0.009) and concomitant hysterectomy (P=0.009). Only 38 (21.3%) women developed UTIs within 12 months of surgery (seven in the ABBREVO procedure group and 31 in the standard transobturator procedure group). No statistically significant between‐group differences were found for the risk of UTI or for urinary tract adverse events, such as recurrent UTI and the need for rehospitalization.ConclusionsThe two procedures were comparable in terms of prevalence and risk factors for UTI during the postoperative period.
Powerful Participatory Literacy for English Learners
Authors: Brown Clara Lee , Schell Robin , Ni Mei 
Published: September 2018

AbstractThe authors showcase critical, participatory literacy as a motivator for English learners’ literacy development. The urban middle school English learners reported in this narrative metamorphosed from reluctant to empowered writers when they inserted themselves into the local politics of school district zoning. Their investment in the zoning issue provided a base for learning argumentative writing as part of state English language arts standards. The students experienced writing as an action that brings about change after receiving a personal response from the superintendent of the school district: a profound realization that the way they view the world matters. Most important, they learned that as active participants, their voices can contribute to the making of a just society.
Industrial‐scale fabrication of an osteogenic and antibacterial PLA/silver‐loaded calcium phosphate composite with significantly reduced cytotoxicity
Authors: Cai Shaobo , Pourdeyhimi Behnam , Loboa Elizabeth G. 
Published: September 2018

AbstractIn this study, we report an industrial‐scale fabrication method of a multifunctional polymer composite as a scaffold material for bone tissue engineering. This study successfully demonstrated the potential of applying industrial polymer processing technologies to produce specially functionalized tissue engineering scaffolds. With the inclusion of a newly synthesized multifunctional additive, silver‐doped‐calcium phosphate (silver‐CaP), the composite material exhibited excellent osteogenic inducibility of human adipose‐derived stem cells (hASC) and satisfactory antibacterial efficacy against Escherichia coli and Staphylococcus aureus. Also, relative to previously reported methods of direct loading silver particles into polymeric materials, our composite exhibited significantly reduced silver associated cytotoxicity. The enhanced biocompatibility could be a significant advantage for materials to be used for regenerative medicine applications where clinical safety is a major consideration. The impact of different silver loading methodologies on hASC’ osteogenic differentiation was also studied. Overall, the results of this study indicate a promising alternative approach to produce multifunctional scaffolds at industrial‐scale with higher throughput, lower cost, and enhanced reproducibility. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 900–910, 2019.
Membranous subaortic stenosis coexisting with hypertrophic cardiomyopathy: A case report
Authors: Xiao‐dong Li , Xin‐yao Liu , Hui Xu , Xiao‐cong Wang 
Published: September 2018

AbstractSubaortic stenosis (SAS) is a congenital heart disease, and its association with hypertrophic cardiomyopathy is very rare and clinically underappreciated. We report here a case of a 45‐year‐old female who was admitted to our hospital with chest tightness and shortness of breath. Both transthoracic and transesophageal echocardiography revealed asymmetric left ventricular hypertrophy and a membrane‐like echo below the level of the aortic valve. This patient was diagnosed with membranous SAS with hypertrophic cardiomyopathy. Screening of her immediate family members revealed that her son also had hypertrophic cardiomyopathy. The patient chose conservative treatments and has been closely followed‐up after discharge.
Relationship of Seminal Megavesicles, Prostate Median Cysts, and Genotype in Autosomal Dominant Polycystic Kidney Disease
Authors: Zhang Weiguo , Stephens Chelsea J. , Blumenfeld Jon D. , Behzadi Ashkan Heshmatzadeh , Donahue Stephanie , Bobb Warren O. , Newhouse Jeffrey H. , Rennert Hanna , Zhao Yize , Prince Martin R. 
Published: September 2018

BackgroundAutosomal dominant polycystic kidney disease (ADPKD) can involve prostate and seminal vesicles but the potential interrelationship of these findings and associations with PKD gene mutation locus and type is unknown.PurposeTo determine the interrelationship of seminal megavesicles (seminal vesicles with lumen diameter > 10mm) and prostatic cysts in ADPKD and to determine whether there are associations with PKD gene mutations.Study TypeRetrospective, case control.PopulationMale ADPKD subjects (n = 92) with mutations in PKD1 (n = 71; 77%) or PKD2 (n = 21; 23%), and age/gender‐matched controls without ADPKD (n = 92).Field Strength/Sequence1.5T, axial/coronal T2‐weighted MR images.AssessmentReviewers blinded to genotype independently measured seminal vesicle lumen diameter and prevalence of cysts in prostate, kidney, and liver.Statistical TestsNonparametric tests for group comparisons and univariate and multivariable logistic regression analyses to identify associations of megavesicles and prostate median cysts with mutations and renal/hepatic cyst burden.ResultsSeminal megavesicles were found in 23 of 92 ADPKD (25%) subjects with PKD1 (22/71, 31%) or PKD2 (n = 1/21, 5%) mutations, but in only two control subjects (P < 0.0001). Prostate median cysts were found in 17/92 (18%) ADPKD subjects, compared with only 6/92 (7%) controls (P = 0.01), and were correlated with seminal vesicle diameters (ρ = 0.24, P = 0.02). Nonmedian prostate cyst prevalence was identical between ADPKD and controls (7/92, 8%). After adjusting for age, estimated glomerular filtration rate, and height‐adjusted total kidney volume, ADPKD subjects with megavesicles were 10 times more likely to have a PKD1 than a PKD2 mutation. Among PKD1 subjects, seminal megavesicles occurred more frequently with nontruncating mutations with less severe kidney involvement.Data ConclusionADPKD is associated with prostate median cysts near ejaculatory ducts. These cysts correlate with seminal megavesicles (dilated to >10 mm) which predict a 10‐fold greater likelihood of PKD1 vs. PKD2 mutation. Cysts elsewhere in the prostate are not related to ADPKD.Level of Evidence: 2Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2019;49:894–903.
Characterizing Structural Changes With Evolving Remyelination Following Experimental Demyelination Using High Angular Resolution Diffusion MRI and Texture Analysis
Authors: Luo Tim , Oladosu Olayinka , Rawji Khalil S. , Zhai Peng , Pridham Glen , Hossain Shahnewaz , Zhang Yunyan 
Published: September 2018

BackgroundChanges in myelin integrity are associated with the pathophysiology of many neurological diseases, including multiple sclerosis. However, noninvasive measurement of myelin injury and repair remains challenging. Advanced MRI techniques including diffusion tensor imaging (DTI), neurite orientation dispersion and density index (NODDI), and texture analysis have shown promise in quantifying subtle abnormalities in white matter structure.PurposeTo determine whether and how these advanced imaging methods help understand remyelination changes after demyelination using a mouse model.Study TypeProspective, longitudinal.Animal ModelDemyelination was induced in the thoracic spinal cord of 21 mice using the chemical toxin lysolecithin.Field Strength/Sequences9.4TAssessmentImaging was done at day 7 (demyelination) and days 14 to 35 (ongoing remyelination) postsurgery, followed by histology. Image analysis focused on both lesions and peri‐lesional areas where remyelination began. In histology, we quantified the complexity of tissue alignment using angular entropy, in addition to staining area.Statistical AnalysisTwo‐way analysis of variance was performed for assessing differences between tissue types and across timepoints, followed by post‐hoc analysis to correct for multiple comparisons (P < 0.05).ResultsAll diffusion and texture parameters were worse in lesions than the control tissue (P < 0.05) except orientation dispersion index (ODI) and neurite density index (NDI) over late remyelination. Longitudinally, ODI decreased and NDI increased persistently in both lesions and peri‐lesion regions (P < 0.05). Fractional anisotropy showed a mild decrease at day 35 after increase, when lesion texture heterogeneity showed a trend to decrease (P > 0.05). Both lesion size and angular entropy decreased over time, and no change in any measure in the control tissue.Data ConclusionDiffusion and MRI texture metrics may provide compensatory information on myelin repair and ODI and NDI could be sensitive measures of evolving remyelination, deserving further validation.Level of Evidence: 1Technical Efficacy: Stage 1J. Magn. Reson. Imaging 2019;49:1750–1759.