bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case of delayed diagnosis of combined urogenita and pulmonary tuberculosis in a patient with abnormal uterine bleeding
Authors: Remneva O. V. , Belnickaya O. A. , Gorbacheva T. I. , Gerval’d V. Ya. , Glios A. P. , Chikmenev A. V. 
Published: November 2024

According to the World Health Organization tuberculosis remains a global health issue for both adult and pediatric populations worldwide. Among women the peak incidence occurs during the active reproductive age, with pregnant women being 1.5–2 times more likely to be affected and experience more severe symptoms than non-pregnant women. In the Altai Region, the epidemiological situation of tuberculosis is characterized by instability, with the incidence rate among women reaching30.5 per 100 000 of the corresponding population in 2022. Delayed diagnosis and treatment can lead to serious complications, including fatal outcomes for both mother and fetus. This article describes a clinical observation of a case of urogenital and pulmonary tuberculosis diagnosed three months after premature abdominal delivery. The course of pregnancy was complicated by acute pleuritis at 13–14 weeks, however, negative results of bacteriological culture of pleural fluid led to the absence of specific tuberculosis treatment and the development of chronic subcompensated placental dysfunction. Three months after delivery, a 34-year-old patient was admitted to the gynecological department of the emergency hospital with abnormal uterine bleeding. The diagnosis was confirmed by histopathology of an endometrial sample revealing tuberculous granulomas without caseous necrosis with epithelioid giant cells of Pirogov – Langhans. Subsequently, generalized tuberculosis was diagnosed in the preterm infant. The negative impact of undiagnosed combined urogenital and pulmonary tuberculosis on the course and outcome of pregnancy is demonstrated, including the development of anemia, placental dysfunction, preterm delivery, puerperal complications, and adverse perinatal outcomes.
Evidence-based medicine: Indole-3-carbinol and resveratrol in human papillomavirus-associated conditions
Authors: Enkova E. V. , Khoperskaya O. V. , Shamarin S. V. , Enkova V. V. , Aseev A. V. 
Published: November 2024

Of all types of cancer in the female reproductive system, cervical cancer has the greatest social significance due to its impact on young patients, often even those who have not yet completed their reproductive function, and it is the third leading cause of cancer-related death. Considering the lack of etiological therapy for human papillomavirus and associated diseases, the high demand for effective methods of medical therapeutic support, and the absence of a gold standard treatment apart from destructive and excisional methods, it seems reasonable to consider the use of nutrients with anticancer effects in the treatment of low-grade cervical intraepithelial neoplasia both as an addition to the watchful waiting strategy and in the use of ablative treatment methods, as well as their adjuvant appointment in the case of obligatory precancer. Based on domestic and foreign literature sources from electronic databases such as PubMed, CyberLeninka, and Elibrary, this review presents data on the use of trans-resveratrol and indole-3-carbinol in HPV-associated diseases. The combination of two mutually complementary anticancer antioxidants – indole-3-carbinol, which primarily has antiproliferative effects, and trans-resveratrol, which restores cellular apoptosis mechanisms, comprehensively affects the pathogenetic mechanisms of the virus-induced pathological process: it has been proven to reduce the expression of oncogenes E6 and E7, increase the expression of tumor suppressor proteins – p53, pRb, PTEN, and decrease markers of proliferation PCNA and Ki-67. The combination of 200 mg of indole-3-carbinol and 60 mg of trans-resveratrol for the prevention of persistent papillomavirus infection and the treatment of cervical intraepithelial neoplasia has impressive potential; however, further research is needed to determine the most effective application schemes.
The diagnostic role of Lactobacillus spp. as representatives of the normal microbiome of the lower urogenital tract
Authors: Bakhtiyarov K. R. , Ignatko I. V. , Siniakova E. V. , Zueva A. S. , Kapyrina T. D. 
Published: November 2024

Currently, scientific knowledge about various Lactobacillus species, which are representatives of the resident flora of the vagina, is actively expanding. We know, lactobacilli are an integral part of the female genital tract. Currently, about 20 different types of lactobacilli are known. Most of the lactobacilli already studied contribute to maintaining vaginal health by providing protection from pathogenic microorganisms, the development of dysbiosis, pregnancy complications, including premature birth. The protective function is provided primarily by the formation of Dand L-forms of lactic acid, which maintains an optimal acidic pH, from the glycogen of the vaginal epithelium. Lactobacillus spp. also prevent adhesion and invasion of pathogens into epithelial cells, synthesize bacteriocins, and inhibit the release of proinflammatory cytokines. However, to date, there is already evidence that not all representatives of lactobacilli have a positive effect on the health of the female body. Thus, patients with the CSTIII morphotype, dominated by L. iners, are especially predisposed to the development of vaginal dysbiosis, and the dominance of L. acidophilus in patients is probably associated with infertility. Currently, there is no reliable evidence of the positive and/or negative effects of many lactobacilli on the female body, and existing studies on a number of bacteria are limited and contradictory. In this regard, it is relevant to further study the characteristics and properties of Lactobacillus spp., colonizing the vagina, for a more accurate understanding of the role of lactobacilli in the vagina and the application of the knowledge gained in clinical practice for the treatment and prevention of various disorders of the normal vaginal microbiome.
A preliminary investigation into the relationship between municipal debt and the financial viability of waterboards in South Africa
Authors: Matlala Moloko , Photolo Mampolelo , Konar Len 
Published: November 2024

ABSTRACT

The provision of water and sanitation services in South Africa is complex due to historical apartheid spatial planning whose remnants are still evident in the democratic country. The rural areas which are mostly occupied by black Africans still, on average, have water services backlog compared to urban areas. At a national level for South Africa to achieve the Sustainable Developmental Goal 6, the country must decisively deal with the backlog and a staggering more than R14 billion debt that the municipalities owe to the waterboards. The current study used the Municipal Strategic Self-Assessment and financial health (FH) check-up tools to determine if there is a causal relationship between the vulnerability of municipalities and the financial viability of waterboards. A linear regression was computed using the SPSS statistical programme to assess the relationship between the FH of the waterboards and the vulnerability index (VI) of the municipalities. It was found that a high VI was more prevalent in the rural municipalities than in the urban municipalities, pointing to a need to develop a differentiated financial framework for these rural municipalities. The study recommended that municipalities should implement remedial actions and waterboards should perform FH check-ups, and there must be consequence management.
Synthesis of bagasse-derived magnetic biochar for the removal of fluoride from water solution
Authors: Takele Deginet , Kalsido Adane Woldemedhin , Wotee Mohammed Wamolo 
Published: November 2024

ABSTRACT

Fluoride levels in drinking water pose a significant environmental threat, and adsorption is a common technique. However, many adsorbent materials have drawbacks such as poor adsorption capabilities, extended contact times, high pH levels, and large dosages. A biochar-based magnetic composite adsorbent has been developed for water defluoridation using a chemical co-precipitation process to immobilize iron particles on the biochar surface. X-ray diffraction analysis, Fourier transformed infrared spectroscopy, Brunauer–Emmett–Teller, and scanning electron microscopy were used to analyse the composite. The central composite design was used to design laboratory tests, which included four input variables: solution pH, dosage, contact time, and initial concentration. The adsorbent dosage was 5.92 g/L, the aqueous pH was 5.79, the contact time was 66.48 min, and the initial fluoride concentration was 12.38 mg/L. The removal efficiency was predicted to be 98.61%, with a 98.55% removal efficiency at optimum conditions. The study concluded that the composite adsorbent can be a reliable and sustainable solution for fluoride removal from water.
Decision support tools for water reuse: a systematic review
Authors: Sampaio Vanda , Santos Ana Silvia Pereira , Lima Maria Manuela 
Published: November 2024

ABSTRACT

This article provides a comprehensive review of decision support tools for water reuse (DST4WR), focusing on microbiological risk assessment (MRA), life cycle analysis (LCA), life cycle cost (LCC), and multi-criteria decision analysis (MCDA). A systematic review of 35 articles published between 2020 and 2024, plus one from 2019, was conducted. The studies were categorised based on the DST4WR applied, with each tool discussed individually. MRA tools assess public health risks in different case studies. LCA identifies key environmental indicators, and its integration with LCC facilitates comprehensive cost analysis. MCDA, applied in various case studies, uses criteria like environmental, social, economic, technical, public health, and functional aspects. Integrating DST4WR tools identifies synergies and trade-offs between criteria, aiding informed decision-making. Combining MRA, LCA/LCC, and MCDA is especially beneficial, as each tool provides a distinct perspective. Using these tools together offers a holistic view of water reuse management, ensuring that all relevant factors are balanced. This approach enhances decision-making and builds stakeholder confidence and acceptance by transparently addressing public health, environmental, economic, and social concerns.
The role of histohematologic barriers and the possibility of using polarization biomedical optics methods in the diagnosis of autoimmune thyroiditis
Authors: Rohovyi Yu.Ye. , Bilookyi O.V. , Ushenko O.H. , Bilookyi V.V. , Semenenko S.B. 
Published: November 2024

Background. Violation of the integrity of the histohematologic barriers (blood-brain, blood-testis, blood-ocular, blood-labyrinth, blood-thyroid) leads to autoimmune damage to these organs. One of the manifestations of the latter is autoimmune thyroiditis, the structural and quantitative changes of which can be more informatively accurately assessed by polarization biomedical optics. The purpose of the study was to substantiate the possibility of using polarization biomedical optics methods in the diagnosis of autoimmune thyroiditis based on the use of pathophysiological analysis of blood-brain barrier integrity disorders. Materials and methods. Two groups of patients were studied: control group 1 — healthy donors (n = 51), study group 2 — people with autoimmune thyroiditis (n = 51) who underwent a puncture biopsy of the thyroid gland for diagnostic purposes. Instrumental laser methods were used: polarization, interference, multifractal. The statistical parameters of polarization ellipticity maps, polarization ellipticity of phase and multifractal spectra of digital microscopic images of native thyroid histological sections in patients with autoimmune thyroiditis were quantified: mean, dispersion, asymmetry, and kurtosis. The probability of differences compared to the controls, taken as 100 %, was evaluated using the Student’s parametric test (p < 0.05). Results. A significant increase in the mean and variance at inhibition of the asymmetry and kurtosis of polarization ellipticity, as well as in the mean and variance at reduction of the asymmetry and kurtosis of polarization ellipticity of phase digital microscopic images of thyroid native histological sections was revealed. There were a significant increase in dispersion and a decrease in the asymmetry and kurtosis of multifractal spectra of polarization ellipticity maps of digital microscopic images of native histological sections. Conclusions. A significant increase in the biophysical optical parameters of digital microscopic images of thyroid native histological sections from patients with autoimmune thyroiditis was found due to the growth of connective tissue in the interstitium as a result of an autoimmune inflammation. There was a significant inhibition of the asymmetry and kurtosis of the ellipticity of polarization of phase digital and multifractal spectra of polarization ellipticity maps of microscopic images of native histological sections in patients with autoimmune thyroiditis due to a decrease in the amount of colloids as a crystalline component caused by damage to the blood-thyroid barrier.
The method of determining abdominal obesity by waist circumference in Ukrainian children
Authors: Gromnatska N.M. , Marushko Yu.V. , Hyshchak T.V. , Belusova V.M. 
Published: November 2024

Background. The prevalence of obesity in children has a trend of constant growth. A third of the pediatric population suffers from excess body weight and obesity, which are associated with such pathological conditions as hypertension, insulin resistance, hyperglycemia, type 2 diabetes, dyslipidemia, metabolic syndrome (MS) and early cardiovascular dysfunction. Waist circumference (WC) measurement is a simple noninvasive screening tool to identify children with abdominal obesity, MS, and increased cardiovascular risk. The purpose of the study was to develop age- and gender-specific WC percentiles for Ukrainian children aged 10–17 years and to determine possible WC cut-offs for detecting abdominal obesity. Materials and methods. 1566 children aged 10–17 were examined, 759 boys and 807 girls. According to the WHO protocol, WC was measured using a flexible centimeter tape in a standing position midway between the lower rib and the upper front edge of the ilium. The threshold point for detecting abdominal obesity was WC ≥ 90th percentile of the distribution according to age and sex (IDF Consensus, 2007). Results. Age and gender percentiles of WC and cut-off at the level of the 90th percentile in Ukrainian children and adolescents are presented. The importance of gender assessment of WC lies in the reliable difference of indicators in children aged 10–12 and 15–17 years and growth of parameters with age in both boys and girls. The need for age assessment of WC is due to increasing the 90th percentile indicators in girls aged 10–17 from 76 to 90.5 cm and in boys from 75.9 to 94 cm. The data obtained can serve as a source for screening and identifying children with abdominal obesity, increased metabolic risk and a better understanding of current trends in childhood obesity. It has been suggested that new WC reference values should be added to clinical examinations to help pediatricians and family physicians reduce cardiovascular risk in children. Conclusions. In the diagnosis of MS in children, it is recommended to use the proposed specific percentiles of WC for sex and age, the values of which ≥ 90th percentile of the distribution should be utilized for detection of abdominal obesity and further diagnosis of MS. Measuring and evaluating WC in routine pediatric examinations is important.
FORMULASI SEDIAAN KRIM MINYAK ATSIRI DAUN KEMANGI (Ocimum sanctum L.) DAN UJI AKTIVITASNYA TERHADAP Sarcoptes scabiei
Authors: Putra Ananto Nugroho , Setiyadi Gunawan 
Published: November 2024

Skabies telah menjadi masalah kesehatan di seluruh dunia yang disebabkan oleh Sarcoptes scabiei. Pengobatan skabies dapat menggunakan skabisida topikal dari tanaman kemangi (Ocimum sanctum L.) disertai dengan pola hidup bersih dan sehat pada penderita dan lingkungannya. Penelitian ini merupakan penelitian eksperimental yang bertujuan untuk memformulasikan sediaan krim minyak dalam air (m/a) dengan berbagai konsentrasi zat aktif minyak atsiri daun kemangi, dan untuk mengetahui pengaruh kadar minyak atsiri daun kemangi terhadap sifat fisik sediaan krim dan aktivitas skabisidanya. Formula konsentrasi minyak atsiri daun kemangi divariasikan menjadi Formula I (5%), Formula II (10%), dan Formula III (20%). Pembuatan krim menggunakan dasar pembentukan sabun anionik trietanolamin stearate dari gabungan reaksi antara asam stearat dan trietanolamin. Hasil uji aktivitas skabisida dapat disimpulkan bahwa adanya perbedaan signifikan Formula I, II, dan III (P = 0,002 < 0,05) dimana dengan pertambahan konsentrasi minyak atsiri daun kemangi meningkatkan uji efektivitasnya membunuh tungau Sarcoptes scabiei. Formula III (32,6 menit) memiliki potensi sebagai skabisida yang lebih baik dibandingkan Formula I (39,17 menit) dan Formula II (36,98 menit) dengan pembanding kontrol permetrin (29 menit).
EVALUASI MUTU PRODUK AKHIR MINUMAN PASTEURISASI PADA UNIT LINE PROSES PRODUKSI DI PRODI TEKNOLOGI PANGAN FAKULTAS TEKNIK UNIVERSITAS PASUNDAN
Authors: RUKMANA JAKA , Ikrawan Yusep , Rohima Ira Endah , Anggraeni Chindy , Salam Wildan Qoharisma 
Published: November 2024

Tujuan penelitian ini yaitu untuk mengetahui mutu produk akhir minuman pasteurisasi pada unit line proses produksi di prodi Teknologi Pangan Fakultas Teknik Universitas Pasundan yang memenuhi SNI. Manfaat yang dapat diberikan oleh penulis adalah memanfaatkan unit line proses yang terdapat di Laboratorium Teknologi Pangan Universitas Pasundan, meningkatkan nilai utilitas dan nilai ekonomis terhadap minuman pasteurisasi, mengurangi ketergantungan masyarakat terhadap minuman yang berpengawet tinggi, meningkatkan produktivitas pangan lokal sebagai bentuk diversifikasi pangan, dan mengetahui proses pembuatan minuman pasteurisasi yang tepat dan berkualitas baik. Rancangan analisis yang dilakukan pada penelitian ini adalah scoring Mutu. Metode ini dilakukan untuk mengetahui apakah minuman pasteurisasi yang dihasilkan pada unit line proses produksi di prodi Teknologi Pangan Fakultas Teknik Universitas Pasundan memenuhi standar mutu sesuai pada SNI 01-3951-1995 dan SNI 3719:2014. Penentuan ini mengacu pada jenis uji yang menjadi persyaratan mutu minuman pasteurisasi. Mutu susu cokelat memenuhi SNI. Dengan kadar protein, viskositas, TPC, Nilai kecerahan (L*) memenuhi nilai minimal yang tertera pada SNI 01-3951-1995 dan memiliki nilai mutu yang lebih baik dibandingkan 2 produk yang berada di pasaran dalam hal atribut warna cokelat dan aroma khas cokelat. Mutu susu murni memenuhi SNI. Dengan kadar protein, TPC, Nilai kecerahan (L*) memenuhi nilai minimal yang tertera pada SNI 01-3951-1995 dan memiliki nilai mutu yang kurang baik dibandingkan 2 produk yang berada di pasaran dalam hal atribut warna putih, rasa asin, konsistensi kekentalan dan aroma khas susu. Mutu sari jeruk lemon memenuhi SNI. Dengan kadar asam total, vitamin C, viskositas, TPC, Nilai kecerahan (L*) memenuhi nilai minimal yang tertera pada SNI 3719:2014 dan memiliki nilai mutu yang lebih baik dibandingkan 2 produk yang berada di pasaran dalam hal atribut rasa asam dan konsistensi kekentalan.
The Effect of Learning Cycle 5E with Animation Media at Student Activities and Learning Outcomes
Authors: Juniar Anna , Sihombing Vioni Angel Prisilya 
Published: November 2024

This study aims to determine the effect of application of Cycle 5E learning model with animation media at learner activities and learning results. The sample was taken by random sampling of 32 learners at experiment and control room. The research was carried out by providing pre-check, after which learning material by nonelectrolyte and electrolyte solutions were applied with the Cycle 5E learning model with animation media at experiment room and the Conventional model at control class, then the posttest. From statistic processing, the following results were obtained: the average activity of learners at the experiment room was 89.76 and the control room was 80.55 with > or 4.59>1.67. The average learning outcome of learners at the experiment room was 81.71 and the control room was 72.96 with > or 5.57>1.67. Correlation between learner activities and learning results of experiment room learners at the calculation rcount Retrieved rcount=0.583 While rtableat α=0.05 (N = 32) is 0.349. With an index determination of 0.33 with a percentage of 33%. This means that there is a correlation between learner activities and learner learning results learned by the Cycle 5E learning model with animation media at material by nonelectrolyte and electrolyte solutions.
Comparative Performance Analysis of Intelligent PID Controllers for a Mechatronic System
Authors: Baciu Andrei , Lazar Corneliu 
Published: November 2024

Abstract
Applications of systems engineering in the automotive field have grown over the past two decades. This paper aims at a Model-Free Control (MFC) strategy for this type of application. It is a control method in the Data Driven Control (DDC) category that is suitable for systems with complex dynamics, uncertainties or dynamics that are difficult to model or with an unavailable model. Considering these reasons, MFC is an appropriate control method applicable to the complex dynamics of automotive systems. This paper presents a comparative analysis of two types of MFC controllers: intelligent proportional (iP) and intelligent proportional derivative (iPD) for a mechatronic system application. The system takes into account the longitudinal speed control of the vehicle. First, some authors results on the design of iP and iPD controllers are reviewed. Then, the intelligent controllers are tested in simulation considering the requirement to maintain the desired vehicle speed under different traffic conditions such as urban and extra-urban driving cycles. The control performances of the iP and iPD controllers are compared using different performance indices, with a classical PID controller added to the comparison.
A Short Review of Deep Learning Methods in Visual Servoing Systems
Authors: Botezatu Adrian-Paul , Burlacu Adrian 
Published: November 2024

Abstract
This survey explores the evolution and applications of Visual Servoing Systems in robotics, emphasizing the transition from traditional image processing techniques to the incorporation of neural networks for feature extraction and control. Robotic systems, integral to manufacturing, surveillance, and healthcare, increasingly rely on Visual Servoing for enhanced interaction within various work environments. Initially focused on auxiliary sensors like visual sensors for robustness and accuracy, recent advances have seen a shift towards integrating deep learning methods for direct control and feature extraction. The survey covers the differences that emerge from classical Visual Servoing architectures to novel methods involving Deep Learning, highlighting their respective advantages and limitations regarding stability, precision, and real-time applicability. Innovative approaches, such as Direct Visual Servoing and the use of siamese networks for camera position estimation, demonstrate significant progress in overcoming the challenges of traditional Visual Servoing. Through detailed examination of leading research, the survey highlights the potential of neural networks to revolutionize this domain by enhancing feature extraction, reducing reliance on precise calibration, and improving control laws for complex robotic tasks.