bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Practitioner’s Guide to Performing a Holistic Evaluation of Technology-Enhanced Learning in Medical Education
Authors: Pickering James D. , Lazarus Michelle D. , Hallam Jennifer L. 
Published: August 2019

AbstractTechnology-enhanced learning (TEL) is now a common mode of educational delivery within medical education. Despite this upsurge, there remains a paucity in comprehensive evaluation of TEL efficacy. In order to make meaningful and evidence-informed decisions on ‘how’ and ‘when’ to utilise technology within a course, ‘useful knowledge’ is required to support faculty in these decision-making processes. In this monograph, a series of pragmatic and achievable approaches for conducting a holistic evaluation of a TEL resource intervention are detailed. These suggestions are based on an established TEL evaluation framework, as well as the author’s own experience and that of the broader literature. The approaches cover development of an appropriate research question that is based on the availability of existing TEL resources alongside the peer-reviewed literature; the development of an appropriate team as well as recommendations for navigating ethical approval; conducting small-scale quantitative and qualitative measure; and performing a large-scale mixed methods assessment to understand the holistic impact of the TEL resource.
The discovery and prediction of vortex flow aerodynamics
Authors: Luckring J.M. 
Published: August 2019

AbstractHigh-speed aircraft often develop separation-induced leading-edge vortices and vortex flow aerodynamics. In this paper, the discovery of separation-induced vortex flows and the development of methods to predict these flows for wing aerodynamics are reviewed. Much of the content for this article was presented at the 2017 Lanchester Lecture and the content was selected with a view towards Lanchester’s approach to research and development.
LANGUAGE REFLECTION FOSTERED BY INDIVIDUAL L2 WRITING TASKS
Authors: López-Serrano Sonia , Roca de Larios Julio , Manchón Rosa M. 
Published: August 2019

AbstractThere has been a growing interest in the study of writing from the perspective of its potential contribution to language development. However, scant attention has been paid to key methodological considerations regarding the analysis of the connection between L2 writing processes, reflection on language while writing, and language learning. In an attempt to advance in this domain, and informed by models of L2 writing, and cognitive L2 writing research framed in the problem-solving paradigm, this study provides a comprehensive description of the language reflection individual writers engage in when solving the linguistic problems they face while completing writing tasks in their L2. The think-aloud protocols generated by 21 EFL learners while writing an individual argumentative essay were analyzed on the basis of a reconceptualization of language-related episodes as problem-solving strategy clusters. The result is a comprehensive, theoretically motivated, and empirically based coding system that is offered as a basis for future research in the domain. We discuss the methodological implications of our analytic approach and advance some theoretical implications for future debates on the language learning potential of individual writing tasks.
Temporal and Spatial Variability of Near‐Inertial Waves in the East/Japan Sea From a High‐Resolution Wind‐Forced Ocean Model
Authors: Jeon Chanhyung , Park Jae‐Hun , Park Young‐Gyu 
Published: August 2019

AbstractNear‐inertial waves (NIWs), a fundamental oceanic response to wind forcing, play an important role in dynamical processes related to ocean mixing and hence have attracted sustained interest. Herein, we investigate temporally and spatially varying NIW distributions in the mixed and deep layers of the East/Japan Sea (EJS) using high‐resolution hourly‐wind‐forced data‐assimilated ocean model outputs. Temporally, the kinetic energy of NIWs in the mixed and deep layers is higher in fall and winter than in spring and summer, showing maxima in December, corresponding to wind forcings of both wind stress and wind‐current resonance. Spatially, the NIW energy in the mixed layer is higher on the northern side of the subpolar front (SPF), although there are no significant spatial differences in the wind forcings. Because of intensive background currents and their vorticities in the upper layer on the southern side of the SPF, vertical transfer of NIW energy is facilitated, shown by a shorter e‐folding decay time scale of NIWs in the mixed layer on the southern side of the SPF. The NIW kinetic energy in the deep layer of 400–1,000 m is higher on the southern side than on the northern side, an opposite spatial pattern to that in the mixed layer, but consistent with a previous observational study. Our results confirm that energetic anticyclonic circulations with negative relative vorticity in the upper layer on the southern side enable vertical penetration of NIW energy from the mixed layer to the deep layer more effectively.
Assimilation of Satellite Altimetry Data for Effective River Bathymetry
Authors: Brêda J. P. L. F. , Paiva R. C. D. , Bravo J. M. , Passaia O. A. , Moreira D. M. 
Published: August 2019

AbstractOne of the main problems of hydrologic/hydrodynamic routing models is defining the right set of parameters, especially on inaccessible and/or large basins. Remote sensing techniques provide measurements of the basin topography, drainage system, and channel width; however current methods for estimating riverbed elevation are not as accurate. This paper presents methods of altimetry data assimilation (DA) for estimating effective bathymetry of a hydrodynamic model. We tested past altimetry observations from satellites ENVISAT, ICESAT, and JASON 2 and synthetic altimetry data from satellites ICESAT 2, JASON 3, SARAL, and Surface Water and Ocean Topography to assess future/present mission's potential. The DA methods used were direct insertion, linear interpolation, the Shuffled Complex Evolution‐University of Arizona optimization algorithm, and an adapted Kalman filter developed with hydraulically based variance and covariance introduced in this paper. The past satellite altimetry DA was evaluated comparing simulated and observed water surface elevation while the synthetic altimetry DA were assessed through a direct comparison with a true bathymetry. The Shuffled Complex Evolution‐University of Arizona and hydraulically based Kalman filter methods presented the best performances, reducing water surface elevation error in 65% in past altimetry data experiment and reducing biased bathymetry error in 75% in the synthetic experiment; however, the latter method is much less computationally expensive. Regarding satellites, it was observed that the performance is related to the satellite intertrack distance, as higher number of observation sites allows more accurate bed elevation estimation.
Enhanced Tropical Cyclone Intensity in the Western North Pacific During Warm Periods Over the Last Two Millennia
Authors: Zhou Xin , Liu Zhonghui , Yan Qing , Zhang Xiaolin , Yi Liang , Yang Wenqing , Xiang Rong , He Yuxin , Hu Bangqi , Liu Yi , Shen Yanan 
Published: August 2019

AbstractIt is assumed that the potential intensity of tropical cyclones (TC) will increase with rising global temperature. The western North Pacific is one of the three principal TC centers, but TC records from the region are scarce and sometimes controversial. Here we present grain‐size distributions and element contents of sediment cores from the East China Sea, in the western North Pacific. We interpret changes in the mean grain size of the coarse fraction as a proxy for TC intensity, and we infer a linkage of TC intensity to temperature changes over the last two millennia. Supported by model simulations, our results show that TC intensity increased (decreased) during relatively warm (cool) periods, confirming the control of temperature on TC intensity on a multicentennial scale. Our results suggest that long‐term TC intensity in the western North Pacific may increase with continued global warming.
Age and Provenance of the Nindam Formation, Ladakh, NW Himalaya: Evolution of the Intraoceanic Dras Arc Before Collision With India
Authors: Walsh Jessica M. J. , Buckman Solomon , Nutman Allen P. , Zhou Renjie 
Published: August 2019

AbstractThe Dras Arc in NW India Himalaya is a belt of basaltic‐andesites intercalated with arkose‐dominated volcaniclastic rocks of the Nindam Formation situated along the Indus Suture between India and Eurasia. Debates exist as to whether these rocks developed in a forearc basin to the Eurasian margin or as part of an intraoceanic island arc system that collided with either India or Eurasia before final continental collision. Detrital zircons from the Nindam Formation yield U‐Pb age spectra with dominant youngest age populations of ~84–125 Ma, corresponding with arc magmatism. Sandstone provenance analysis from the Nindam Formation indicates that the Dras Arc evolved from an undissected arc to dissected arc over a period of ~41 Myr. Slightly older, smaller populations occur at ~135–185 Ma, corresponding with reported ages of Neotethyan ophiolites (e.g., Spongtang). The basal section of the Nindam Formation reveals the presence of arc‐derived basaltic‐andesite and tonalite clasts, plus ophiolitic components sourced from an adjacent accretionary complex. There is a distinct absence of quartz or felsic granitic clasts, suggesting that the Nindam Formation did not develop as a forearc basin to the Ladakh Batholith of southern Eurasia but rather as separate intraoceanic island arc. A distinct “Gondwanan” signature occurs in all samples, with zircon age peaks at ~514–988, ~1000–1588, ~1627–2444, and ~2500 Ma. We suggest that the Dras and Spong arcs are the same intraoceanic island arc system that developed as a result of subduction initiation along NNE‐SSW transform faults perpendicular to the Indian and Eurasia continents.
A genome-wide positioning systems network algorithm for in silico drug repurposing
Authors: Cheng Feixiong , Lu Weiqiang , Liu Chuang , Fang Jiansong , Hou Yuan , Handy Diane E. , Wang Ruisheng , Zhao Yuzheng , Yang Yi , Huang Jin , Hill David E. , Vidal Marc , Eng Charis , Loscalzo Joseph 
Published: August 2019

AbstractRecent advances in DNA/RNA sequencing have made it possible to identify new targets rapidly and to repurpose approved drugs for treating heterogeneous diseases by the ‘precise’ targeting of individualized disease modules. In this study, we develop a Genome-wide Positioning Systems network (GPSnet) algorithm for drug repurposing by specifically targeting disease modules derived from individual patient’s DNA and RNA sequencing profiles mapped to the human protein-protein interactome network. We investigate whole-exome sequencing and transcriptome profiles from ~5,000 patients across 15 cancer types from The Cancer Genome Atlas. We show that GPSnet-predicted disease modules can predict drug responses and prioritize new indications for 140 approved drugs. Importantly, we experimentally validate that an approved cardiac arrhythmia and heart failure drug, ouabain, shows potential antitumor activities in lung adenocarcinoma by uniquely targeting a HIF1α/LEO1-mediated cell metabolism pathway. In summary, GPSnet offers a network-based, in silico drug repurposing framework for more efficacious therapeutic selections.
MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer
Authors: Dammert Marcel A. , Brägelmann Johannes , Olsen Rachelle R. , Böhm Stefanie , Monhasery Niloufar , Whitney Christopher P. , Chalishazar Milind D. , Tumbrink Hannah L. , Guthrie Matthew R. , Klein Sebastian , Ireland Abbie S. , Ryan Jeremy , Schmitt Anna , Marx Annika , Ozretić Luka , Castiglione Roberta , Lorenz Carina , Jachimowicz Ron D. , Wolf Elmar , Thomas Roman K. , Poirier John T. , Büttner Reinhard , Sen Triparna , Byers Lauren A. , Reinhardt H. Christian , Letai Anthony , Oliver Trudy G. , Sos Martin L. 
Published: August 2019

AbstractMYC paralogs are frequently activated in small cell lung cancer (SCLC) but represent poor drug targets. Thus, a detailed mapping of MYC-paralog-specific vulnerabilities may help to develop effective therapies for SCLC patients. Using a unique cellular CRISPR activation model, we uncover that, in contrast to MYCN and MYCL, MYC represses BCL2 transcription via interaction with MIZ1 and DNMT3a. The resulting lack of BCL2 expression promotes sensitivity to cell cycle control inhibition and dependency on MCL1. Furthermore, MYC activation leads to heightened apoptotic priming, intrinsic genotoxic stress and susceptibility to DNA damage checkpoint inhibitors. Finally, combined AURK and CHK1 inhibition substantially prolongs the survival of mice bearing MYC-driven SCLC beyond that of combination chemotherapy. These analyses uncover MYC-paralog-specific regulation of the apoptotic machinery with implications for genotype-based selection of targeted therapeutics in SCLC patients.
Construction of stabilized bulk-nano interfaces for highly promoted inverse CeO2/Cu catalyst
Authors: Yan Han , Yang Chun , Shao Wei-Peng , Cai Li-Hua , Wang Wei-Wei , Jin Zhao , Jia Chun-Jiang 
Published: August 2019

AbstractAs the water-gas shift (WGS) reaction serves as a crucial industrial process, strategies for developing robust WGS catalysts are highly desiderated. Here we report the construction of stabilized bulk-nano interfaces to fabricate highly efficient copper-ceria catalyst for the WGS reaction. With an in-situ structural transformation, small CeO2 nanoparticles (2–3 nm) are stabilized on bulk Cu to form abundant CeO2-Cu interfaces, which maintain well-dispersed under reaction conditions. This inverse CeO2/Cu catalyst shows excellent WGS performances, of which the activity is 5 times higher than other reported Cu catalysts. Long-term stability is also very solid under harsh conditions. Mechanistic study illustrates that for the inverse CeO2/Cu catalyst, superb capability of H2O dissociation and CO oxidation facilitates WGS process via the combination of associative and redox mechanisms. This work paves a way to fabricate robust catalysts by combining the advantages of bulk and nano-sized catalysts. Catalysts with such inverse configurations show great potential in practical WGS applications.
A flexible readout mechanism of human sensory representations
Authors: Birman Daniel , Gardner Justin L. 
Published: August 2019

AbstractAttention can both enhance and suppress cortical sensory representations. However, changing sensory representations can also be detrimental to behavior. Behavioral consequences can be avoided by flexibly changing sensory readout, while leaving the representations unchanged. Here, we asked human observers to attend to and report about either one of two features which control the visibility of motion while making concurrent measurements of cortical activity with BOLD imaging (fMRI). We extend a well-established linking model to account for the relationship between these measurements and find that changes in sensory representation during directed attention are insufficient to explain perceptual reports. Adding a flexible downstream readout is necessary to best explain our data. Such a model implies that observers should be able to recover information about ignored features, a prediction which we confirm behaviorally. Thus, flexible readout is a critical component of the cortical implementation of human adaptive behavior.
Maternal control of suspensor programmed cell death via gibberellin signaling
Authors: Shi Ce , Luo Pan , Du Yu-Ting , Chen Hong , Huang Xiaorong , Cheng Tian-He , Luo An , Li Hong-Ju , Yang Wei-Cai , Zhao Peng , Sun Meng-Xiang 
Published: August 2019

AbstractPlant embryos are generated and develop in a stable and well-protected microenvironment surrounded by maternal tissue, which is vital for embryogenesis. However, the signaling mechanisms responsible for maternal tissue-to-proembryo communication are not well understood. Here, we report a pathway for maternal tissue-to-proembryo communication. We identify a DELLA protein, NtCRF1 (NtCYS regulative factor 1), which regulates suspensor programmed cell death (PCD). NtCRF1 can bind to the promoter of NtCYS and regulate the suspensor PCD-switch module NtCYS-NtCP14 in response to gibberellin (GA). We confirm that GA4, as a primary signal triggering suspensor PCD, is generated in the micropylar endothelium by the transient activation of NtGA3oxs in the maternal tissue. Thus, we propose that GA is a maternal-to-proembryo communication signal that is decoded in the proembryo by a GID1-CRF1-CYS-CP14 signaling cascade. Using this mode of communication, maternal tissue precisely controls the embryonic suspensor PCD and is able to nurse the proembryo in a stage-dependent manner.
Constructing Smaller Pauli Twirling Sets for Arbitrary Error Channels
Authors: Cai Zhenyu , Benjamin Simon C. 
Published: August 2019

AbstractTwirling is a technique widely used for converting arbitrary noise channels into Pauli channels in error threshold estimations of quantum error correction codes. It is vitally useful both in real experiments and in classical quantum simulations. Minimising the size of the twirling gate set increases the efficiency of simulations and in experiments it might reduce both the number of runs required and the circuit depth (and hence the error burden). Conventional twirling uses the full set of Pauli gates as the set of twirling gates. This article provides a theoretical background for Pauli twirling and a way to construct a twirling gate set with a number of members comparable to the size of the Pauli basis of the given error channel, which is usually much smaller than the full set of Pauli gates. We also show that twirling is equivalent to stabiliser measurements with discarded measurement results, which enables us to further reduce the size of the twirling gate set.
Examining the identification of age-related atrophy between T1 and T1 + T2-FLAIR cortical thickness measurements
Authors: Lindroth Heidi , Nair Veena A. , Stanfield Casandra , Casey Cameron , Mohanty Rosaleena , Wayer Daniel , Rowley Paul , Brown Roger , Prabhakaran Vivek , Sanders Robert D. 
Published: August 2019

AbstractCortical thickness is traditionally derived from T1-weighted MRI images. Recent studies have shown an improvement in segmentation with the combination of T1 + T2-FLAIR images. MRI data from 54 adults (mean: 71 years, 65–81 years, 48% females) that are part of an ongoing cohort study were analyzed to investigate whether T1 + T2-FLAIR cortical thickness measurements were superior to those derived from T1-weighted images in identifying age-related atrophy. T1-weighted and T2-FLAIR MRI images were processed through FreeSurfer v6.0. Data was extracted using the Desikan-Killiany (DKT) atlas. FreeSurfer’s GUI QDEC examined age-related atrophy. Nonparametric tests, effect sizes, and Pearson correlations examined differences between T1-only and T1 + T2-FLAIR cortical thickness data. These analyses demonstrated that T1 + T2-FLAIR processed images significantly improved the segmentation of gray matter (chi-square x2, p < 0.05) and demonstrated significantly thicker cortical thickness means (p < 0.05) with medium to large effect sizes. Significant regions of age-related cortical atrophy were identified within the T1 + T2-FLAIR data (FDR corrected, p < 0.05). This is in contrast to the T1-only data where no regions survived FDR correction. In summary, T1 + T2-FLAIR data were associated with significant improvement in cortical segmentation and the identification of age-related cortical atrophy. Future studies should consider employing this imaging strategy to obtain cortical thickness measurements sensitive to age-related changes.
Sharing of heteroplasmies between human liver lobes varies across the mtDNA genome
Authors: Hübner Alexander , Wachsmuth Manja , Schröder Roland , Li Mingkun , Eis-Hübinger Anna Maria , Madea Burkhard , Stoneking Mark 
Published: August 2019

AbstractMitochondrial DNA (mtDNA) heteroplasmy (intra-individual variation) varies among different human tissues and increases with age, suggesting that the majority of mtDNA heteroplasmies are acquired, rather than inherited. However, the extent to which heteroplasmic sites are shared across a tissue remains an open question. We therefore investigated heteroplasmy in two liver samples (one from each primary lobe) from 83 Europeans, sampled at autopsy. Minor allele frequencies (MAF) at heteroplasmic sites were significantly correlated between the two liver samples from an individual, with significantly more sharing of heteroplasmic sites in the control region than in the non-control region. We show that this increased sharing for the control region cannot be explained by recent mutations at just a few specific heteroplasmic sites or by the possible presence of 7S DNA. Moreover, we carried out simulations to show that there is significantly more sharing than would be predicted from random genetic drift from a common progenitor cell. We also observe a significant excess of non-synonymous vs. synonymous heteroplasmies in the protein-coding region, but significantly more sharing of synonymous heteroplasmies. These contrasting patterns for the control vs. the non-control region, and for non-synonymous vs. synonymous heteroplasmies, suggest that selection plays a role in heteroplasmy sharing.
A trade-off between speckle size and intensity enhancement of a focal point behind a scattering layer
Authors: Edrei Eitan , Scarcelli Giuliano 
Published: August 2019

AbstractFocusing light through highly scattering materials by modifying the phase profile of the illuminating beam has attracted a great deal of attention in the past decade paving the way towards novel applications. Here we report on a tradeoff between two seemingly independent quantities of critical importance in the focusing process: the size of the focal point obtained behind a scattering medium and the maximum achievable intensity of such focal point. We theoretically derive and experimentally demonstrate the practical limits of intensity enhancement of the focal point and relate them to the intrinsic properties of the scattering phenomenon. We demonstrate that the intensity enhancement limitation becomes dominant when the focusing plane gets closer to the scattering layer thus limiting the ability to obtain tight focusing at high contrast, which has direct relevance for the many applications exploring scattering materials as a platform for high resolution focusing and imaging.