bluuebunny/crossref_metadata_2025_split huggingface dataset:
Botulinumtoxin-kezelés infantilis cerebralis paresisben
Authors: Terebessy Tamás , Domos Gyula , Hevér Dalma , Horváth Nikoletta , Kiss Sándor , Szőke György 
Published: July 2019

Abstract: Introduction: Botulinum toxin is used for decreasing spasticity, improving gait pattern and preventing secondary deformities and orthopedic surgeries in children with cerebral palsy. Despite its wide use, there is no evidence for the long-term beneficial effect of the toxin. Aim: The authors focused on the short-term effects of the toxin and on the subjective evaluation done by the parents about the botox treatment. Method: First, the calf muscle of 18 children was treated and casting was also performed. In our second patient group, multilevel lower limb injection was done in 12 cases. Joints’ range of motion, muscle tone and spasticity were assessed before and 4–6 weeks after treatment. In ambulatory children, gait analysis was done. Side effects were recorded and parental opinion about the treatment was requested. Results: Increased ankle range of motion and decreased muscle tone and spasticity were seen in our first patient group. In the second group, hip flexion contracture became milder and hip abduction and the popliteal angle improved. However, gait analysis results only slightly changed after botox treatment. Occasional mild and transient adverse effects were observed during the pharmacologically active period of the toxin. Associate beneficial effects were also reported such as better comfort, easier movements, improving function of the non-injected upper limb, decreasing dysarthria and dysphagia. Conclusion: Our study strengthens the observation that botox treatment of the spastic calf muscle together with plaster casting can result in improved ankle dorsiflexion. Multilevel botox treatment can improve lower limb joints range of motion, however, gait pattern remains unchanged. The administration of botulinum toxin with respect to the guidelines has no major adverse effects. Further studies are needed to clarify the observed beneficial associate effects of the toxin. Orv Hetil. 2019; 160(28): 1105–1111.
Surface flaws control strain localization in the deformation of Cu|Au nanolaminate pillars
Authors: Gola Adrien , Zhang Guang-Ping , Pastewka Lars , Schwaiger Ruth 
Published: July 2019

AbstractThe authors carried out matched experiments and molecular dynamics simulations of the compression of nanopillars prepared from Cu|Au nanolaminates with up to 25 nm layer thickness. The stress–strain behaviors obtained from both techniques are in excellent agreement. Variation in the layer thickness reveals an increase in the strength with a decreasing layer thickness. Pillars fail through the formation of shear bands whose nucleation they trace back to the existence of surface flaws. This combined approach demonstrates the crucial role of contact geometry in controlling the deformation mode and suggests that modulus-matched nanolaminates should be able to suppress strain localization while maintaining controllable strength.
Optimalisasi Pelayanan Haji dalam Meningkatkan Kepuasan Jamaah
Authors: Wildayati Resti 
Published: July 2019

This study aims to determine the from, responsiveness and guarantee in increasing satisfaction given by the Hajj and Umrah Organization of the Ministry of Religion of Karawang district in an effort to increase the satisfaction of the pilgrims. In order to answer the problem as follows: how the form of service fasilities, responsiveness in helping and guarantee in increasing the satisfaction of worshipers. This study uses a qualitative methode with a descriptive approach with data collection techniques used in observation, interview and documentation techniques. The results of this study indicate that the optimalization of Hajj services in increasing congregation satisfaction can be concluded that (1) the form of service facilities in the field of organizing Hajj and Umrah is sufficiently proven as evidended by the convenience of providing service, adequate use of technology and supporting onte-stop pilgrimage services can facilitate, (2) Responsiveness in helping and providing service is carried out by placing staaf in accordance with the expertien of each, (3) Guarantees provided in creasing satisfaction are carried out through administrative guarantees, security and scientic.AbstrakPenelitian ini bertujuan untuk mengetahui wujud, ketanggapan dan jaminan dalam meningkatkan kepuasan yang diberikan oleh Penyelenggaraan Haji dan Umrah kementerian agama kabupaten karawang dalam upaya meningkatkan kepuasan jamaah haji. Dalam rangka menjawab permasalahan sebagai berikut: bagaimana wujud fasilitas pelayanan, ketanggapan dalam membantu dan jaminan dalam meningkatkan kepuasan jamaah. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif dengan teknik pengumpulan data yang digunakan teknik observasi, wawancara dan dokumentasi. Hasil penelitian ini menunjukan bahwa optimalisasi pelayanan haji dalam meningkatkan kepuasan jamaah dapat ditarik kesimpulan bahwa (1) Wujud fasilitas pelayanan di bidang penyelenggaran haji dan umrah sudah memadai terbukti dengan adanya kenyamanan tempat dalam memberikan pelayanan, penggunaan teknologi yang memadai dan adanya penunjang pelayanan haji satu atap yang dapat memudahkan, (2) Ketanggapan dalam membantu dan menyediakan pelayanan dilakukan dengan menempatkan staff sesuai dengan keahlian masing-masing staff, (3) Jaminan yang diberikan dalam meningkatkan kepuasan dilakukan dengan melalui jaminan administrasi, jaminan keamanan dan jaminan keilmuan.
Pola Komunikasi Kelompok pada Komunitas Pecinta Film Islami
Authors: Soleh Aqoma 
Published: July 2019

The rapid development of films increases the birth of communities. Film lovers are one of the Islami c Film Lovers Community (KOPFI). In the Islami c Film Lovers Community a new social space is formed which influences the interaction and communication behavior between group members. The purpose of this study is to find out the process of communication and evaluation in finding the unity of opinion in the Bandung Islami c Film Lovers Community. The method used is a qualitative method with the Social Comparison Theory approach from Festinger. Data is collected through observation and interviews. The results of the study show that members of the Bandung Islami c Film Lovers Community in their activities have roles which are in accordance with the structure and level of their main tasks and functions. Communication patterns become an important tool that must be considered to maintain harmony and cohesiveness in the community of Bandung Regional Islami c Film Lovers. As a film discussion forum, Members of the Islami c Film Lovers Community evaluate and share information using various languages as group identities.AbstrakPerkembangan film yang semakin pesat mendorong lahirnya komunitas-komunitas pecinta film salah satunya Komunitas Pecinta Film Islami (KOPFI). Di KOPFI dalam komunikasi kelompoknya terbentuk ruang sosial baru yang memengaruhi perilaku interaksi dan komunikasi antar anggota kelompok. Penelitian ini bertujuan untuk mengetahui pola komunikasi, evaluasi diri, perbandingan dan perbaikan diri di Komunitas Pecinta Film Islami (KOPFI) Bandung. Metode penelitian yang digunakan adalah metode kualitatif dengan pendekatan Teori Perbandingan Sosial dari Festinger. Data dikumpulkan melalui observasi, wawancara dan dokumentasi. Hasil penelitian menunjukkan bahwa anggota Komunitas Pecinta Film Islami Bandung dalam kegiatannya memiliki peran yang sesuai dengan struktur dan tingkatan dari tugas pokok dan fungsinya. Pola komunikasi menjadi sebuah alat penting yang mampu menciptakan atau menjaga keharmonisan dan kohesivitas di komunitas Pecinta Film Islami Regional Bandung. Sebagai forum diskusi film, Anggota Komunitas Pecinta Film Islami saling melakukan evaluasi dan berbagi informasi, pengetahuan dan pengalaman yang dapat menuingkatkan kemampuan masing-masing anggota, dengan menggunakan ragam bahasa sebagai identitas kelompok.
The Role of the EGF Receptor in Sex Differences in Kidney Injury
Authors: Zhang Ming-Zhi , Sasaki Kensuke , Li Yan , Li Zhilian , Pan Yu , Jin Guan-nan , Wang Yinqiu , Niu Aolei , Wang Suwan , Fan Xiaofeng , Chen Jian Chun , Borza Corina , Yang Haichun , Pozzi Ambra , Fogo Agnes B. , Harris Raymond C. 
Published: July 2019

Significance Statement
Sex differences in the predisposition to CKD development or progression are well known. However, the underlying mechanisms involved remain unclear. The authors found markedly greater renal EGF receptor (EGFR) expression levels in adult wild-type male versus female mice, and a similar sex difference in EGFR expression in normal adult human kidneys. In Dsk5 mutant mice with constitutive EGFR activation, males developed significant spontaneous glomerular and tubulointerstitial injury, whereas females were relatively spared. In female mice, oophorectomy did not affect renal EGFR expression, but testosterone increased it; in male mice, castration decreased renal EGFR expression. These findings indicate that differential expression in renal EGFR expression plays a role in sex differences in susceptibility to progressive kidney injury, one that may be mediated in part by testosterone.

Background
Sex differences mediating predisposition to kidney injury are well known, with evidence indicating lower CKD incidence rates and slower decline in renal function in nondiabetic CKD for premenopausal women compared with men. However, signaling pathways involved have not been elucidated to date. The EGF receptor (EGFR) is widely expressed in the kidney in glomeruli and tubules, and persistent and dysregulated EGFR activation mediates progressive renal injury.

Methods
To investigate the sex differences in response to renal injury, we examined EGFR expression in mice, in human kidney tissue, and in cultured cell lines.

Results
In wild type mice, renal mRNA and protein EGFR levels were comparable in males and females at postnatal day 7 but were significantly lower in age-matched adult females than in adult males. Similar gender differences in renal EGFR expression were detected in normal adult human kidneys. In Dsk5 mutant mice with a gain-of-function allele that increases basal EGFR kinase activity, males had progressive glomerulopathy, albuminuria, loss of podocytes, and tubulointerstitial fibrosis, but female Dsk5 mice had minimal kidney injury. Oophorectomy had no effect on renal EGFR levels in female Dsk5 mice, while castration protected against the kidney injury in male Dsk5 mice, in association with a reduction in EGFR expression to levels seen in females. Conversely, testosterone increased EGFR expression and renal injury in female Dsk5 mice. Testosterone directly stimulated EGFR expression in cultured kidney cells.

Conclusions
These studies indicate that differential renal EGFR expression plays a role in the sex differences in susceptibility to progressive kidney injury that may be mediated at least in part by testosterone.
Performance of GFR Slope as a Surrogate End Point for Kidney Disease Progression in Clinical Trials: A Statistical Simulation
Authors: Greene Tom , Ying Jian , Vonesh Edward F. , Tighiouart Hocine , Levey Andrew S. , Coresh Josef , Herrick Jennifer S. , Imai Enyu , Jafar Tazeen H. , Maes Bart D. , Perrone Ronald D. , del Vecchio Lucia , Wetzels Jack F.M. , Heerspink Hiddo J.L. , Inker Lesley A. 
Published: July 2019

Significance Statement
Randomized controlled trials of CKD traditionally use clinical events that happen late in the course of CKD progression as study end points. Doing this requires large sample sizes and long follow-up periods that can make the studies very costly. The authors use statistical simulations to investigate circumstances in which using the change in GFR over time or GFR slope as a study end point reduces the required sample size or trial duration compared with clinical end points. They found that GFR slope performs better than clinical end points when patients’ initial GFRs are high and the treatment has no acute effect on GFR. The results along with other recent studies suggest GFR is a valid surrogate end point for CKD clinical trials that may allow for more efficient trials and help speed the development of new CKD therapies.

Background
Randomized trials of CKD treatments traditionally use clinical events late in CKD progression as end points. This requires costly studies with large sample sizes and long follow-up. Surrogate end points like GFR slope may speed up the evaluation of new therapies by enabling smaller studies with shorter follow-up.

Methods
We used statistical simulations to identify trial situations where GFR slope provides increased statistical power compared with the clinical end point of doubling of serum creatinine or kidney failure. We simulated GFR trajectories based on data from 47 randomized treatment comparisons. We evaluated the sample size required for adequate statistical power based on GFR slopes calculated from baseline and from 3 months follow-up.

Results
In most scenarios where the treatment has no acute effect, analyses of GFR slope provided similar or improved statistical power compared with the clinical end point, often allowing investigators to shorten follow-up by at least half while simultaneously reducing sample size. When patients’ GFRs are higher, the power advantages of GFR slope increase. However, acute treatment effects within several months of randomization can increase the risk of false conclusions about therapies based on GFR slope. Care is needed in study design and analysis to avoid such false conclusions.

Conclusions
Use of GFR slope can substantially increase statistical power compared with the clinical end point, particularly when baseline GFR is high and there is no acute effect. The optimum GFR-based end point depends on multiple factors including the rate of GFR decline, type of treatment effect and study design.
EBEVEYNLİK BİÇİMİNİN KİŞİLİK ÖZELLİKLERİ, BENLİK SAYGISI VE YAŞAM DOYUMUNU YORDAMA GÜCÜ
Authors: Tuzgöl Dost Meliha , Aytaç Mert , Kıbrıslıoğlu Uysal Nermin 
Published: July 2019

Bu araştırmanın amacı, ebeveynlik biçiminin kişilik
özellikleri, benlik saygısı ve yaşam doyumunu yordama gücünü araştırmaktır.
Araştırmada ilişkisel araştırma deseni kullanılmıştır. Araştırma grubu
Ankara’da bir devlet üniversitesinin Eğitim Fakültesinin çeşitli bölümlerinde
okumakta olan 441 lisans öğrencisinden oluşmaktadır. Katılımcıların 375’i (%
85) kadın, 66’sı (% 15) erkektir. Öğrencilerin yaş aralığı 18-36 olup, yaş
ortalaması 20.71’dir (Ss: 1.82). Araştırmada, Young Ebeveynlik Ölçeği,
Sıfatlara Dayalı Kişilik Testi,
Rosenberg Benlik Saygısı Ölçeği-Benlik Saygısı Alt Ölçeği, Yaşam Doyumu
Ölçeği ve Kişisel Bilgi Formu kullanılmıştır. Ebeveynlik biçimlerinin,
öğrencilerin beş büyük faktör kişilik özelliklerini, benlik saygısı ve yaşam
doyumunu yordama gücünün incelenmesi amacıyla çoklu regresyon analizi
yapılmıştır. Bazı ebeveynlik biçimlerinin üniversite öğrencilerinin nevrotizm,
dışadönüklük, deneyime açıklık, yumuşak başlılık, sorumluluk, benlik saygısı ve
yaşam doyumunu anlamlı olarak yordadığı saptanmıştır. Sonuçlar tartışılmış ve
çeşitli önerilerde bulunulmuştur.
2018 TÜRKÇE ÖĞRETİM PROGRAMI ÇERÇEVESİNDE HAZIRLANAN 8. SINIF TÜRKÇE DERS KİTABININ DEĞERLENDİRİLMESİ
Authors: Çarkıt Cafer 
Published: July 2019

Bu
çalışmada 2018 Türkçe Öğretim Programına göre hazırlanmış 8. sınıf Türkçe ders
kitapları değerlendirilmektedir. Bu çerçevede kitapta yer alan etkinliklerin
okuma, yazma, konuşma ve dinleme ile dil bilgisi alanlarına yönelik dağılımı
ile metinlerin türler açısından kullanım sıklıkları tespit edilmiştir. Ayrıca
kitabı okutan 8 Türkçe öğretmeni ile görüşme yapılarak kitaba yönelik öğretmen
görüşleri alınmıştır. Araştırmada veriler doküman incelemesi ve yarı
yapılandırlmış görüşme formu ile toplanmıştır. Elde edilen verilerin
analizinde nitel araştırma yöntemlerinden içerik analizi kullanılmıştır.
Veriler araştırma sorularının ortaya koyduğu temalara göre düzenlenmiştir.
Ulaşılan bulgular araştırmanın alt problemlerine göre tanımlanmıştır.
Araştırmada etkinliklerin öğrenme alanlarına göre düzenli bir dağılım
göstermediği, bilgilendirici ve öyküleyici metinlerin şiir türüne göre daha
fazla olduğu sonuçlarına ulaşılmıştır. Ayrıca öğretmenler metin seçimi, şiir seçimi ve tema sözlüğüne yer
vermesi açısından kitabı olumlu bulmakta; öğrencilerin ilgisini çekmemesi,
güncel konuları içermemesi, tema değerlendirmelerinin basit olması ve görsel
içeriklerin zengin olmaması yönünden ise kitabı olumsuz bulmaktadır.
Los inicios de la lexicografía hispano-japonesa
Authors: Rojo-Mejuto Natalia 
Published: July 2019

El objetivo de este artículo es analizar los diccionarios plurilingües publicados en Japón durante los siglos XVI y XVII en el contexto de las misiones religiosas. Para ello se propone una caracterización de la lingüística misionera hispano-japonesa y se define el contexto en el que nacen estas obras lexicográficas y sus objetivos. Asimismo, se estudia la evolución del proceso de aprendizaje de la lengua japonesa por parte de los misioneros españoles, así como la autoría colectiva de las obras y los condicionantes tipográficos. En particular, se analizan el Dictionarium Latino Lusitanicum ac Iaponicum (1595), el Vocabulario da lingoa de Iapam (1603) y el Vocabulario de Iapon (1630) y se defiende su vigencia actual tanto en el estudio de los niponismos en lengua española como en su tratamiento lexicográfico.
Leader's Influence and Communication Styles on the Culture of Innovation in FIFGROUP
Authors: Iswanti Margareta Enik , Rahmanto Andre , Muktiyo Widodo 
Published: July 2019

This papers learn about leadership dan communication styles on the culture of innovation in FIFGROUP, The leader are be visionary, competence, be able ti influence team for innovation and encourage his team and make effectivelly communications to take part in the organization. Indicator Success an organization when the leader walk the talk, able to effective communication, has contibution performance, focus to innovation process and be role model as part of the innovation culture organization.When Organization face the problem about innovation, innovation is suck and useless for another subordinat buat for company innovation is must be create. Case Study in (PT. FEDERAL INTERNATIONAL FINANCE) FIFGROUP one of member Astra International very interesting because in FIFGROUP on of Astra International member focus on innovation but innovation not yet a part of daily task and performance. Success Indicator function leader as role model is important thing, internalization Values, mindset inovation is important to make FIFGROUP sustainability, effective Communication and sense or urgency when organization face the problem and able love change in era digital.
COMPORTAMIENTO DE EDIFICIOS DE ACERO CON CONTRAVENTEOS EXCÉNTRICOS ANTE SECUENCIAS SÍSMICAS
Authors: Ruiz García Jorge , Bojórquez Mora Edén , Corona Villar Edgar José , Reyes Salazar Alfredo 
Published: July 2019

En este artículo se presentan los resultados de un estudio analítico enfocado a evaluar el comportamiento sísmico de edificios de acero estructurados a base de marcos y contraventeos excéntricos (MCE). Para tal fin, se modelaron dos MCE de 4 y 8 niveles mediante la plataforma computacional OpenSees. En particular, se modeló el comportamiento histerético de los eslabones en los contraventeos excéntricos considerando un criterio de falla, así como la zona del panel en las uniones viga-columna. Los MCE en estudio fueron sometidos a un conjunto de secuencias sísmicas evento principal-réplicas artificiales, las cuales son representativas de secuencias registradas en terreno blando de la Ciudad de México. Los resultados de está investigación indican que los eslabones pueden fallar ante la acción de réplicas intensas, lo cual conduce a un incremento de sus demandas de distorsión máxima de entrepiso respecto a las originadas por el evento principal. Ante esta situación, se observó que las vigas y columnas cercanas al eslabón que falla exhiben un comportamiento inelástico, lo cual es contrario a su filosofía de diseño. Finalmente, se aprecio que los MCE exhiben una concentración de distorsión máxima de entrepiso en los pisos inferiores dado que los eslabones no tienen un comportamiento histerético uniforme en la altura, lo cual desaprovecha su capacidad de disipación de energía.
EFEKTIVITAS PEMBELAJARAN BERBASIS DARING: SEBUAH BUKTI PADA PEMBELAJARAN BAHASA INGGRIS
Authors: Khusniyah Nurul Lailatul , Hakim Lukman 
Published: July 2019

Abstrak: Penelitian ini menggambarkan efektifitas pembelajaran berbasis daring terhadap kemampuan mahasiswa dalam memahami teks berbahasa Inggris. Pembelajaran daring yang digunakan dalam penelitian ini adalah pembelajaran yang memanfaatkan penggunaan web blog. Paparan pada artikel ini adalah bagian dari laporan penelitian tindakan kelas yang fokus utamanya adalah melihat efektivitas pembelajaran berbasis daring yang ditinjau dari dua pendekatan, yaitu perbandingan distribusi data dan uji-t pada data sebelum tindakan (pretest) dan setalah tindakan (posttest). Hasil penelitian menunjukkan bahwa ada perbedaan kemampuan pemahaman mahasiswa terhadap teks berbahasa Inggris antara sebelum dan sesudah penggunaan web blog. Dalam hal ini, pembelajaran daring berbantuan web blog tersebut memberikan pengaruh positif terhadap peningkatan kemampuan membaca bahasa Inggris mahasiswa.
Abstract: This study describes the effectiveness of online-based learning on the students’ ability to understand English-language texts. The online learning used in this study is learning that utilizes the use of web blogs. This article is a part of the report of a classroom action research which focuses on identifying the effectiveness of the online-based learning viewed from two approaches, namely the comparison of data distribution and t-test on the data before the treatments (pretest) and after the treatments (posttest). The results of the study show that there are differences in students' ability to understand English texts before and after the use of the web blogs. In this case, online learning assisted by the web blog has a positive influence on improving students' English reading skills.
Analisis Data Panel pada Tingkat Pengangguran Terbuka Kabupaten/Kota di Pulau Jawa
Authors: Pratiwi Hasih , Prawastyorini Ardina Nilam , Sugiyanto Sugiyanto 
Published: July 2019

Unemployment rate is the percentage of the number of unemployed to the total labor force, it has become some problems in economic development. The aim of this study is to choose the best model between common, fixed, and random effects in modeling open unemployment rate of regency/city in Java. It based on open unemployment rate with several influence factors in Java Island 2010-2016 which are panel data types. The best model choosen based on the results of the Chow test and Hausman test. The fixed effect model was obtained as the best model with a value of 79,26 percent.