bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practical aspects of oligopeptide AAKLVFF as an alignment medium for the measurements of residual dipolar coupling of organic molecules
Authors: Liu Han , Chen Pian , Li Xiao‐Lu , Sun Han , Lei Xinxiang 
Published: January 2019

AbstractPractical aspects of the oligopeptide AAKLVFF as an alignment medium are discussed, including large‐scale synthesis of the oligopeptide, detailed description of preparation of the alignment medium, and acquisition of the RDCs. The resulting orienting medium is stable and highly homogeneous with tunable alignment strength in methanol. We demonstrated its applicability on the stereochemical elucidation of two natural products, oridonin and α‐santonin.
Ethical considerations of using a single minor donor for three bone marrow harvests for three HLA‐matched siblings with primary immunodeficiency
Authors: Parikh Suhag H. , Pentz Rebecca D. , Haight Ann , Adeli Mehdi , Martin Paul L. , Driscoll Timothy A. , Page Kristin , Kurtzberg Joanne , Prasad Vinod K. , Barfield Raymond C. 
Published: January 2019

AbstractAllogeneic hematopoietic stem cell transplantation is curative for primary immunodeficiencies. Bone marrow from an unaffected human leukocyte antigen (HLA)‐identical sibling donor is the ideal graft source. For minor donors, meaningful consent or assent may not be feasible, and permission from parents or legal guardians is considered acceptable. Adverse events, albeit extremely small, can be associated with bone marrow harvest in pediatric donors. Donor safety concerns potentially increase with multiple bone marrow harvests. Very little is known about multiple bone marrow harvests from pediatric donors. We describe the ethical considerations and clinical decision‐making in an unusual clinical situation where three patients with the same primary immunodeficiency were HLA identical to one another and their younger sibling, who underwent bone marrow harvests three times between 1.3 and 4 years of age, resulting in successful transplantation for all three patients. We hope that this experience will provide guidance to providers and families in a similar situation.
Diffuse panbronchiolitis: A progressive fatal lung disease that is curable with azithromycin, but only if diagnosed!
Authors: Weinberger Miles , Lesser Daniel 
Published: January 2019

AbstractDiffuse panbronchiolitis (DPB) is a rare progressive and eventually fatal pulmonary disease first identified in Japan and initially seen predominantly in Southeast Asia. Macrolide antibiotics rapidly reverse symptoms and pathology, and their use increased the 5 and 10‐year survival from 50 and 30 percent, respectively, to over 90%. Review of 181 case reports from previous publications found patients with DPB commonly had their pulmonary symptoms preceded by rhinosinusitis, frequently by many years. Long delays in diagnosis for many years were common. The review further identified DPB in all ethnic groups and multiple areas outside of Southeast Asia. Although diagnosis was most commonly made in adults, 13% of the diagnoses were made in children and nine of the adult cases described onset in childhood. Few cases of relapse were reported, but extended periods of monitoring after treatment were not generally present.
Evaluation of Rice stripe virus transmission efficiency by quantification of viral load in the saliva of insect vector
Authors: Li Jing , Zhao Wan , Wang Wei , Zhang Lili , Cui Feng 
Published: January 2019

AbstractBACKGROUNDPersistent plant viruses transfer from insect gut to the hemolymph, and finally to the salivary glands before inoculation into the plant hosts with saliva during insect feeding. Virus accumulation in saliva is an important indicator for the transmission ability of an insect vector. In order to evaluate the transmission ability of the small brown planthopper to rice stripe virus (RSV), we successfully measured accumulation of RSV in the saliva of planthoppers via the absolute real‐time quantitative polymerase chain reaction method by quantifying the copy numbers of viral genes.RESULTSAfter feeding on an artificial diet for 24 h, the copy numbers of viral genes of capsid protein (CP) and disease‐specific protein (SP) can be detected in the saliva collected from as few as ten viruliferous planthoppers and ten non‐viruliferous planthoppers after infected with RSV for 7 days. When the expression of planthopper G protein pathway suppressor 2 or c‐Jun N‐terminal kinase was knocked down, the copy numbers of CP and SP in the saliva varied accordingly.CONCLUSIONOur study provided an accurate and convenient detection system to evaluate the transmission efficiency of RSV by small brown planthoppers, and this method may also be suitable for other persistent plant viruses. © 2019 Society of Chemical Industry
Disease severity in respiratory syncytial virus infection: Role of host genetic variation
Authors: Tahamtan Alireza , Askari Fatemeh Sana , Bont Louis , Salimi Vahid 
Published: January 2019

SummaryRespiratory syncytial virus (RSV) infection is the most common cause of bronchiolitis and pneumonia in the pediatric population worldwide. The immunopathology of RSV infection varies considerably and severe disease occurs only in a minority of the population. There are many factors (host, viral, and environmental) that contribute to the complicated disease phenotype. In this regard, host factors are decisive for pulmonary susceptibility to RSV infection. Host genetic diversity certainly affects the balance between control of viral replication and tissue damage during RSV infection, consequently impacting on diseases outcome. In this review, we discuss the role of host genetic variation in disease caused by RSV aiming to highlight genetic risk factors for one of the most common diseases in early childhood. Our findings clearly indicate that the response of each individual to infection is influenced by genetic diversity mainly linked to the regulation of host immune responses. Future genetic association and functional studies using more powerful and consistently reproducible approaches will likely be able to confirm, refine, and expand our developing concept of RSV disease pathogenesis.
Socioeconomic status, social‐cultural values, life stress, and health behaviors in a national sample of adolescents
Authors: Milas Goran , Klarić Irena Martinović , Malnar Ana , Šupe‐Domić Daniela , Slavich George M. 
Published: January 2019

AbstractAdolescence is a developmental period during which time individuals adopt health behaviors that affect their lifelong health and disease risk. Socioeconomic status, social‐cultural values, and stress have all been hypothesized to play a role in this association, but very few studies have examined how these factors interrelate and explain differences in health behaviors in adolescence. To address this issue, we assessed youths' socioeconomic status, social‐cultural values, life stress levels across seven domains, and health behaviors in a national sample of 1,830 high school seniors living in the four largest cities in Croatia. Structural equation modelling examined the extent to which stress mediates the effects of socioeconomic status and social‐cultural values on positive and negative health behaviors. As hypothesized, stress levels significantly mediated associations between youths' socioeconomic status, social‐cultural values, and healthy and unhealthy habits. Additionally, whereas better socioeconomic status predicted less stress, greater social‐cultural value on achieving a “good life” predicted more stress. More stress, in turn, was associated with engaging in fewer healthy behaviors for both males and females, and more unhealthy behaviors for males. Socioeconomic status and social‐cultural values thus appear to influence stress levels, which may in turn affect adolescents' health behaviors and, potentially, their lifespan health.
Shear‐displacement diagram of steel plate shear walls with precompression from adjacent frame columns
Authors: Lv Yang , Li Ling , Wu Di , Chen Yu , Li Zhong‐xian , Chouw Nawawi 
Published: January 2019

SummaryAn analytical model of the unstiffened steel plate shear wall (SPSW) considering precompression from the adjacent frame columns is proposed and experimentally verified. First, the distribution and transferring of the gravity loads between boundary columns and the infill steel plate was proposed. Second, the shear‐displacement diagram of the SPSW under compression–shear interaction was obtained, and to further consider the global bending deformation, the shear‐displacement diagram of the SPSW under compression–shear–bending interaction was obtained. Third, the load‐carrying capacities and deformations at the state of elastic buckling of the infill steel plate, the yield of Zones I and III, the yield of Zone II, and the yield of the boundary frame were presented. Finally, cyclic loading test on four scaled one story single bay unstiffened SPSWs under different axial forces at the top of the columns was carried out to verify the proposed analytical model. Shear‐displacement relationship, shear capacity, and envelope curves of the specimens were compared with the predicted values. Results indicate that the proposed analytical model can reasonably predict the decrease of the shear load capacity and stiffness of the SPSWs due to the existence of the axial load at the boundary columns.
Cyber-Physical System to Improve Machining Process Performance
Authors: Armendia Mikel , Fuertjes Tobias , Plakhotnik Denys , Sossenheimer Johaness , Flum Dominik 
Published: January 2019

AbstractMachining process is set-up in the machines at different levels of maturity. While in large batch manufacturing, a long time is spent in process design and optimization, and in small batch production, the process design time is limited, and the designed process is far to be optimized. In any case, the possibility to control and optimize the process at machine level is very important to increase the productivity. The concept of cyber-physical systems (CPS) is introduced in this paper to increase machine tool performance and process productivity. Several CPS-based features developed in Twin-Control are presented.
Visualization of Simulated and Measured Process Data
Authors: Plakhotnik Denys , Berglind Luke , Stautner Marc , Euhus Dirk , Ozturk Erdem , Fuertjes Tobias , Murtezaoglu Yavuz 
Published: January 2019

AbstractAlthough process monitoring can facilitate to detect deviations from required part quality and safe process conditions, the analysis and postprocessing of the measured data are not embedded into the CAx workflow. Binding the measurement data together with material removal simulation creates a powerful tool for CAM programmers and process engineers. The user can analyze 3D visualization of the machining process more intuitively. A developed CAM integration simulates material removal considering the actual tool coordinates (measured during the process) and can depict the acquired and simulated cutting conditions (spindle torque, axes accelerations, etc.) with various color schemes on in-process stock simulation.
Twin-Control Evaluation in Industrial Environment: Automotive Case
Authors: Armendia Mikel , Ghassempouri Mani , Selmi Jaouher , Berglind Luke , Sossenheimer Johannes , Flum Dominik , Peysson Flavien , Fuertjes Tobias , Plakhotnik Denys 
Published: January 2019

AbstractThis chapter presents the evaluation of Twin-Control in an automotive validation scenario consisting in the production line of a RENAULT electrical motor component that is composed by three COMAU machine tools. Automotive industry requires very optimized and controlled machining process, due to large batches and tight margin cost. In addition, life-cycle features like energy consumption and maintenance costs are of special relevance. The evaluation covers the different stages of the product developing cycle. This document highlights different obtained results of the implementation of Twin-Control features and their impact. Great benefits are provided to the industrial end-users.
Towards Energy-Efficient Machine Tools Through the Development of the Twin-Control Energy Efficiency Module
Authors: Flum Dominik , Sossenheimer Johannes , Stück Christian , Abele Eberhard 
Published: January 2019

AbstractEnergy efficiency is an essential quality and cost feature of modern machine tools. The main measures to increase energy efficiency have been investigated many times and are therefore well known. Nevertheless, it must be noted that even with new machine tools, on many occasions only part of this potential is exploited. One reason for this is that the benefits of an energy efficiency measure are not transparent in the planning phase. This often results in a design according to the lowest investment costs. The energy efficiency module of Twin-Control is a simulation tool to support machine tool builders in choosing an optimal machine configuration regarding both the investment and the energy costs. An essential element is simulation models based on physical modelling. These can predict the energy demand of modules within machine tools without prior measurements and ensure that the technical requirements are maintained. During the automated compilation and evaluation of the configuration, the optimization algorithm of the platform, amongst other things, accesses a component database. Using the configuration platform allows the machine manufacturer to offer an individually customized machine tool with the lowest total costs to the machine user.
New Approach for Bearing Life Cycle Estimation and Control
Authors: Olabarrieta Eneko , Konde Egoitz , Guruceta Enrique , Armendia Mikel 
Published: January 2019

AbstractA new approach for the control of the life cycle of rolling bearings in machine tools is presented. The approach is based on a new simulation tool that has been developed using the well-known ISO 281 standard as a reference. This new tool improves the accuracy of the estimations in two fields: model-based and feature-based prognostics. The tool provides accurate end-of-life estimations, thanks to the determination of more realistic component loads for a defined manufacturing cycle. In addition, it can be embedded in monitoring devices using real machine tool usage data and calculate remaining useful life (RUL) of the analyzed component. Experimental tests confirm that the ISO 281 standard overestimates end-of-life of bearings under controlled conditions and presents vibration analysis as a key tool for an early detection of bearing failure. Indeed, the application of the module for remaining useful life calculation should be combined with vibration-based condition monitoring in order to detect unexpected component degradation.
Method and Analysis
Authors: Lien Marianne Inéz , Lorentzen Jørgen 
Published: January 2019

AbstractIn this short chapter we outline the three sub-studies which comprise the basis of this book. We give an account of the selection process for those men we have interviewed in this qualitative study, and the kinds of violence of which they have been victim. We also outline our methods of interview and analysis and the ethical aspects of interviewing victims of violence.
Men’s Experience of Intimate Partner Violence
Authors: Lien Marianne Inéz , Lorentzen Jørgen 
Published: January 2019

AbstractIn this chapter we present men’s experience of intimate partner violence and discuss their experiences in the light of Michael P. Johnson’s typologies of intimate partner violence. We also offer descriptions of some of the men’s childhood experiences of violence. To the best of our knowledge, there are few narrative studies on men’s experiences with partner violence that have investigated men’s childhood experiences, and we have therefore chosen to devote a relatively large amount of the chapter to this subject. The interview studies are part of a visibility project. Both in the Nordic and international contexts, there are few qualitative studies of men’s experiences of partner violence. In this chapter we look in detail at men’s experiences, asking: When and where does the violence occur? How they have experienced this violence? What have the consequences been on their health, working life and relationships with other people? Several of the men’s stories share common features and also bear similarities to those presented in earlier research on the experiences of women victims of violence. The participants from immigrant backgrounds all describe a childhood in which it was quite common for children to be hit, especially by fathers, but also teachers and other people in authority. They are reluctant to call it violence; it was so common in their experience that they saw nothing special about it. As we will see in this chapter, the interviews reveal a complex variety of reasons for the men having ended up in violent relationships.
The Need to Develop the Established Theory of Partner Violence Further
Authors: Lien Marianne Inéz , Lorentzen Jørgen 
Published: January 2019

AbstractThis chapter opens with a discussion about Johnson’s (2008) concepts of intimate terrorism and situational violence. We found that the majority of the men we interviewed have been subjected to intimate terrorism, which provides the basis for a renewed theorisation of domestic violence. Traditional patriarchal values are not the sole source of such violence. Theories must be expanded to include complex psychological mechanisms and the need for control across genders. The main focus of research within men’s studies to date has been on men as perpetrators; however, our material shows that there is a need for more nuanced research on men as victims to understand masculinity/ies in a contemporary context. It highlights that structural theories about gender must be supplemented with more psychological and phenomenological theories to achieve a greater understanding of domestic violence as a whole.
The Queer Materiality of History: H.D., Freud and the Bronze Athena
Authors: Funke Jana 
Published: January 2019

AbstractThis chapter presents a new reading of the relationship between modernist author H.D. (Hilda Doolittle) and Sigmund Freud. It focuses on the bronze statuette of Athena that was part of the psychoanalyst’s collection of antiquities and played an important role in his analytical sessions with H.D. in 1933–34. The chapter demonstrates that the material qualities of bronze took on a specific meaning in H.D.’s writings, especially Tribute to Freud (1956). In contrast to white marble, which was linked to transcendence and abstraction, the materiality of bronze drew attention to the difficulties of reaching back to the past. H.D. and Freud shared a queer attachment to the partially damaged bronze statuette, which was associated with the inevitable losses of history as well as the possibility of anachronistic survival. As such, the ancient object facilitated dialogue between H.D. and Freud and their literary and scientific projects.
Dark monopoles in Grand Unified Theories
Authors: Deglmann Maria de Lourdes Z. P. , Kneipp Marco A. C. 
Published: January 2019

AbstractWe consider a Yang-Mills-Higgs theory with gauge groupG= SU(n) broken toGv= [SU(p) × SU(n−p) × U(1)]/Zby a Higgs field in the adjoint representation. We obtain monopole solutions whose magnetic field is not in the Cartan Subalgebra. Since their magnetic field vanishes in the direction of the generator of the U(1)emelectromagnetic group, we call them Dark Monopoles. These Dark Monopoles must exist in some Grand Unified Theories (GUTs) without the need to introduce a dark sector. We analyze the particular case of SU(5) GUT, where we obtain that their mass isM = 4πvẼ(λ/e2)/e, whereẼ(λ/e2) is a monotonically increasing function ofλ/e2withẼ(0) = 1.294 andẼ(∞) = 3.262. We also give a geometrical interpretation to their non-abelian magnetic charge.
U(1) gauge vector field on a codimension-2 brane
Authors: Fu Chun-E , Zhong Yuan , Liu Yu-Xiao 
Published: January 2019

Abstract

In this paper, we obtain a gauge invariant effective action for a bulk massless U(1) gauge vector field on a brane with codimension two by using a general Kaluza-Klein (KK) decomposition for the field. It suggests that there exist two types of scalar KK modes to keep the gauge invariance of the action for the massive vector KK modes. Both the vector and scalar KK modes can be massive. The masses of the vector KK modes m
(n) contain two parts, m
1
(
n)
and m
2
(
n)
, due to the existence of the two extra dimensions. The masses of the two types of scalar KK modes m

ϕ

(
n)
and m

φ

(
n)
are related to the vector ones, i.e., m

ϕ

(
n)
= m
1
(
n)
and m

φ

(
n)
= m
2
(
n)
. Moreover, we derive two Schrödinger-like equations for the vector KK modes, for which the effective potentials are just the functions of the warp factor.
The Diagnostic Accuracy of Radiographs and Magnetic Resonance Imaging in Predicting Deltoid Ligament Ruptures in Ankle Fractures
Authors: Warner Stephen J. , Garner Matthew R. , Fabricant Peter D. , Schottel Patrick C. , Loftus Michael L. , Hentel Keith D. , Helfet David L. , Lorich Dean G. 
Published: January 2019

Background Operative indications for supination-external rotation (SER) ankle fractures depend on the integrity of the medial structures. Despite the importance of assessing deep deltoid ligament injuries, the accuracy of common diagnostic tests has not been established. Questions/Purposes The objective of this study was to compare the ability of injury (non-stress) and stress radiographs and magnetic resonance imaging (MRI) to diagnose deep deltoid ligament ruptures in operative SER ankle fractures. Methods Patients were included who underwent surgical fixation of SER ankle fractures and had appropriate injury and manual stress test radiographs, pre-operative ankle MRI, and intra-operative assessment of deep deltoid integrity by direct visualization. The medial clear space (MCS) was considered positive for all values over 5 mm on the injury or stress mortise radiographs. MRI analysis of the deep deltoid ligament injury was performed by blinded fellowship-trained musculoskeletal radiologists. Intra-operative direct visualization and assessment of the deltoid was performed using a direct medial ankle approach at the time of operative fracture fixation. Results Using intra-operative visualization as the gold standard, MCS measurements and MRI had differing abilities to diagnose a deep deltoid rupture. In cases where the MCS was less than 5 mm on injury radiographs and stress tests were performed, MCS measurements were much less accurate than MRI in predicting deltoid ruptures (46% versus 79%, respectively) with a high false positive rate (80%). In contrast, an MCS measurement of greater than 5 mm on injury radiographs was a strong predictor of deep deltoid rupture (accuracy of 95%). Conclusion Compared with direct visualization of the deltoid ligament intra-operatively, these data support proceeding with surgery when the MCS on injury radiographs is greater than 5 mm without any additional stress tests or advanced imaging. When the MCS is less than 5 mm, we recommend MRI analysis because of its increased accuracy and decreased false positive rate. Improving our ability to diagnose deltoid ruptures will contribute to more effective management of patients with SER ankle fractures.