bluuebunny/crossref_metadata_2025_split huggingface dataset:
Früherkennung von Morbus Crohn anhand von oralen Manifestationen bei einer Patientin mit Marfan-Syndrom
Authors: Topbas Ayla , von Bremen Julia , Gattenlöhner Stefan , Ruf Sabine , Meyle Jörg 
Published: October 2018

Zusammenfassung
Ziel Dieser Fallbericht zeigt eine Patientin mit der Anamnese des Marfan-Syndroms (MFS) und einer atypischen gingivalen Hyperplasie, die zu einer frühen Diagnose von Morbus Crohn führte.
Material und Methoden Die Patientin zeigte typische kraniofaziale Manifestationen des Marfan-Syndroms. Zusätzlich stellte sich eine zunächst einseitige, dann symmetrische atypische Gingivahyperplasie im Frontzahnbereich dar. Die antiinfektiöse Parodontaltherapie verbesserte den überlagerten entzündlichen Teil des hyperplastischen Parodonts, aber die Hyperplasie blieb zu einem großen Teil bestehen.
Ergebnisse Die vermutete frühe Manifestation des Morbus Crohn im Oralbereich wurde histologisch durch eine Biopsie bestätigt. Morbus Crohn wurde anschließend durch eine internistische Endoskopie verifiziert.
Fazit Das Durchschnittsalter der Patienten, die sich einer kieferorthopädischen Behandlung unterziehen, entspricht dem Alter, in dem sich systemische Erkrankungen oft zum ersten Mal manifestieren. Orale Symptome können die ersten Anzeichen einer systemischen Erkrankung sein, wie in diesem Fall Morbus Crohn, und bieten somit die Möglichkeit zur Früherkennung durch Kieferorthopäden und Allgemeinzahnärzte.
Empfehlungen zur Diagnostik und Therapie bei krebskranken Kindern mit Fieber und Neutropenie – Vergleich zweier aktueller Leitlinien
Authors: Lehrnbecher Thomas , Groll Andreas , Agyeman Philipp , Ammann Roland , Attarbaschi Andishe , Behrends Uta , Berger Christoph , Hamprecht Axel , Hufnagel Markus , Laws Hans-Jürgen , Scheler Max , Temme Christian , Vieth Simon , Simon Arne 
Published: October 2018

ZusammenfassungKrebskranke Kinder und Jugendliche haben aufgrund der Beeinträchtigung ihres Immunsystems ein erhöhtes Risiko für Infektionen. Die Neutropenie ist der wichtigste Risikofaktor für infektiöse Komplikationen, und Fieber in der Neutropenie stellt einen pädiatrischen Notfall dar. Während für Erwachsene mit Fieber in der Neutropenie bereits seit langem Leitlinien existieren, finden sich eigene Leitlinien für Kinder und Jugendliche erst seit wenigen Jahren. Sie sind von Bedeutung, da pädiatrische Patienten sich von Erwachsenen in vielen Punkten wie Grunderkrankung, Komorbidität sowie verfügbare Arzneimittel unterscheiden. Im vorliegenden Artikel werden die wichtigsten Gemeinsamkeiten und Unterschiede der jüngst erschienenen interdisziplinären Leitlinie der Deutschen Gesellschaft für Pädiatrische Infektiologie (DGPI) und Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH) sowie einer Leitlinie eines internationalen Expertenpanels für Kinder mit Fieber und Neutropenie herausgearbeitet und diskutiert.
Moderne Trainingstherapie bei Herz-Kreislauf-Erkrankungen
Authors: Edel Klaus 
Published: October 2018

SummaryKörperliche Bewegung kann den Verlauf von Gefäßerkrankungen positiv beeinflussen und die Sterblichkeit bei Herz-Kreislauf-Erkrankungen senken. Entscheidend dabei ist neben der Häufigkeit vor allem die Intensität der Bewegung. Die Dosierung der Intensität des Sportprogramms orientiert sich entweder am Energieverbrauch oder an der aeroben Kraft, die während der körperlichen Aktivität angewendet wird. Welcher Sport ausgeübt wird, hat jedoch keinen eindeutigen Einfluss auf den Gesundheitseffekt.
Mit Pflanzenstoffen gegen erhöhtes Cholesterin
Authors: Schmiedel Volker 
Published: October 2018

SummaryPflanzliche Nahrungs- oder Heilmittel können auf 3 unterschiedliche Arten cholesterinsenkend wirken. Ballaststoffe in Pflanzen, wie zum Beispiel Apfelpektin oder Ballaststoffe in Flohsamen, sind in der Lage, Cholesterin oder dessen Derivate zu binden und damit die Resorption bzw. die Rückresorption zu behindern. Choleretisch wirkende Pflanzeninhaltsstoffe, zum Beispiel aus der Artischocke, verstärken die Ausscheidung von Cholesterin und Gallensäuren über die Galle. Bestimmte Pflanzeninhaltsstoffe wie Monacolin K aus dem Roten Reis behindern die körpereigene Cholesterinsynthese. Dieser Beitrag stellt die wichtigsten cholesterinsenkenden Heilpflanzen, deren Wirkprinzipien und die entsprechende Studienlage vor.
The Effect of Magnesium and Vitamin E Co-Supplementation on Glycemic Control and Markers of Cardio-Metabolic Risk in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
Authors: Jamilian Mehri , Sabzevar Niloufar Kazemi , Asemi Zatollah 
Published: October 2018

AbstractData on the effects of magnesium and vitamin E co-supplementation on glycemic control and markers of cardio-metabolic risk of patients with polycystic ovary syndrome (PCOS) were collected. This investigation was conducted to evaluate the effects of magnesium and vitamin E co-supplementation on glycemic control and markers of cardio-metabolic risk in women with PCOS. This randomized, double-blind, placebo-controlled trial was carried out on 60 women with PCOS, aged 18–40 years old. Participants were randomly divided into two groups to receive 250 mg/day magnesium plus 400 mg/day vitamin E supplements or placebo (n=30 each group) for 12 weeks. Fasting blood samples were taken at baseline and after the 12-week intervention to quantify related variables. After the 12-week intervention, compared with the placebo, magnesium and vitamin E co-supplementation led to a significant reduction in serum insulin levels (–1.1±3.0 vs. +1.6±3.7 μIU/ml, p=0.003) and homeostatic model of assessment for insulin resistance (–0.2±0.7 vs. +0.4±0.9, p=0.002), and a significant increase in the quantitative insulin sensitivity check index (+0.01±0.01 vs. –0.009±0.02, p=0.003). Furthermore, magnesium plus vitamin E supplementation significantly decreased serum triglycerides (–15.0±24.4 vs. +6.7±22.2 mg/dl, p=0.001) and VLDL-cholesterol concentrations (–3.0±4.9 vs. +0.6±2.4 mg/dl, P=0.01) compared with the placebo. A trend toward a greater decrease in total cholesterol levels was observed in magnesium plus vitamin E group compared to placebo group (–7.0±32.6 vs. +8.1±26.6 mg/dl, p=0.05). In conclusion, magnesium and vitamin E co-supplementation for 12 weeks to PCOS women had beneficial effects on parameters of insulin metabolism and few markers of cardio-metabolic risk.
Experiencia quirúrgica en el manejo de litiasis urinaria en la población pediátrica: estudio multicéntrico
Authors: Figueroa Victor , Torres Lynda , García Carlos , Prada Stefania , Castillo Mariangel , Pérez Jaime 
Published: October 2018

Introducción y Objetivos La incidencia de litiasis urinaria en pediatría ha venido en aumento en los últimos años. Las indicaciones quirúrgicas están bien establecidas en la literatura, y con la disponibilidad actual de instrumental quirúrgico de calibre reducido diseñado para pacientes pediátricos, el manejo de esa entidad, ha tenido una evolución dramática. Mediante este estudio, se describe la experiencia quirúrgica de dos centros de referencia en el manejo de litiasis urinaria en población pediátrica.
Métodos se realizó un estudio multicéntrico, observacional descriptivo y retrospectivo. Se incluyeron pacientes menores de 18 años que fueron sometidos a algún manejo quirúrgico para enfermedad litiásica urinaria entre diciembre de 2010 y marzo de 2017. Los datos demográficos, evaluación pre-quirúrgica, características del cálculo, complicaciones y cálculos residuales fueron registrados, así́ como la tasa de éxito de los procedimientos. Se realizó un análisis estadístico descriptivo con medidas de frecuencia utilizando el software SPSS.
Resultados Un total de 18 pacientes y 19 procedimientos fueron incluidos. La media de edad fue 7,9 años (1–16), las presentaciones clínicas más comunes fueron dolor lumbar e infección de vías urinarias en un 42% y un 37% respectivamente. El diagnóstico se realizó mediante Urotac en la mayoría de pacientes (83%). La media del número y tamaño de los cálculos fue 1,9 (DE 3,1) y 14,8 mm (DE 10,92) respectivamente. La localización más común fue piélica (31%), seguido de uréter distal (26%), 2 (10%) pacientes tuvieron cistolitiasis y 4 (21%) pacientes tuvieron cálculos en diferentes localizaciones. Se realizaron 7 (37%) ureterolitotomías retrógradas endoscópicas (ULE) semirrígidas, 6 (31%) ULE flexibles, 3 (16%) cistolitotomías y 2 (10%) nefrolitotomías percutáneas. Un 53% de los casos, tenían catéter doble J previo al procedimiento y en un 68% de los casos, se dejó catéter doble J después del procedimiento. La tasa de éxito de las cirugías fue de un 89%. No se documentaron complicaciones intraoperatorias ni postoperatorias.
Conclusiones La litiasis urinaria en la población pediátrica es una entidad poco común. El tratamiento quirúrgico tiene alta tasa de éxito y es seguro. Se necesitan estudios con mayor nivel de evidencia para determinar el esquema terapéutico quirúrgico apropiado de esa población.
Impact of Exercise/Sport on Well-being in Congenital Bleeding Disorders
Authors: Fasoli Silvia , Gandini Giorgio , Giuffrida Anna , Franchini Massimo 
Published: October 2018

AbstractPhysical activity provides many benefits in patients with congenital bleeding disorders. Patients with hemophilia are encouraged to participate in exercise and sports, especially those patients receiving prophylaxis. Several publications and guidelines have explored this issue in hemophilia patients, evaluating in particular the impact of physical activity on patients' well-being and quality of life. The other rare congenital bleeding disorders are less studied; they are heterogeneous in terms of clinical bleeding phenotype, incidence of hemarthrosis, and arthropathy. Furthermore, prophylaxis in these patients is less common than in hemophilia patients, which must be considered when choosing the type of physical and sporting activity. In this review, the authors have analyzed the literature focusing their attention on those rare coagulation disorders that may be complicated by arthropathy and the role of exercise and sports in this context.
Noncanonical autophagy at ER exit sites regulates procollagen turnover
Authors: Omari Shakib , Makareeva Elena , Roberts-Pilgrim Anna , Mirigian Lynn , Jarnik Michal , Ott Carolyn , Lippincott-Schwartz Jennifer , Leikin Sergey 
Published: October 2018

Significance
Type I collagen, a major component of bone, skin, and other connective tissues, is synthesized in the endoplasmic reticulum (ER) and passes through the secretory pathway. Rerouting of its procollagen precursor to a degradative pathway is crucial for reducing intracellular buildup in pathologies caused by defects in procollagen folding and trafficking. Here, we identify an autophagy pathway initiated at ER exit sites (ERESs). Procollagen proteins following this pathway accumulate at ERESs modified with ubiquitin, LC3, p62, and other autophagy machinery. Modified ERESs carrying procollagen are then engulfed by lysosomes through a microautophagy-like mechanism, not involving conventional, double-membrane autophagosomes. Procollagen homeostasis thus involves a noncanonical mode of autophagy initiated at ERESs, which might also be important in degradation of other secretory proteins.
Strain-GeMS: optimized subspecies identification from microbiome data based on accurate variant modeling
Authors: Tan Chongyang , Cui Wei , Cui Xinping , Ning Kang 
Published: October 2018

Abstract

Motivation
Subspecies identification is one of the most critical issues in microbiome studies, as it is directly related to their functions in response to the environmental stress and their feedbacks. However, identification of subspecies remains a challenge largely due to the small variation between different strains within the same species. Accurate identification of subspecies primarily relies on variant identification and categorization through microbiome data. However, current SNP calling and subspecies identification for microbiome data remain underdeveloped.

Results
In this work, we have proposed Strain-GeMS for subspecies identification from microbiome data, based on solid statistical model for SNP calling, as well as optimized procedure for subspecies identification. Results on simulated, ab initio and in vivo datasets have shown that Strain-GeMS could always generate more accurate results compared with other subspecies identification methods.

Availability and implementation
Strain-GeMS is available at: https://github.com/HUST-NingKang-Lab/straingems.

Supplementary information
Supplementary data are available at Bioinformatics online.
A new method bridging graph theory and residue co-evolutionary networks for specificity determinant positions detection
Authors: da Fonseca Néli José , Afonso Marcelo Querino Lima , de Oliveira Lucas Carrijo , Bleicher Lucas 
Published: October 2018

Abstract

Motivation
Computational studies of molecular evolution are usually performed from a multiple alignment of homologous sequences, on which sequences resulting from a common ancestor are aligned so that equivalent residues are placed in the same position. Residues frequency patterns of a full alignment or from a subset of its sequences can be highly useful for suggesting positions under selection. Most methods mapping co-evolving or specificity determinant sites are focused on positions, however, they do not consider the case for residues that are specificity determinants in one subclass, but variable in others. In addition, many methods are impractical for very large alignments, such as those obtained from Pfam, or require a priori information of the subclasses to be analyzed.

Results
In this paper we apply the complex networks theory, widely used to analyze co-affiliation systems in the social and ecological contexts, to map groups of functional related residues. This methodology was initially evaluated in simulated environments and then applied to four different protein families datasets, in which several specificity determinant sets and functional motifs were successfully detected.

Availability and implementation
The algorithms and datasets used in the development of this project are available on http://www.biocomp.icb.ufmg.br/biocomp/software-and-databases/networkstats/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Inferring disease-associated long non-coding RNAs using genome-wide tissue expression profiles
Authors: Pan Xiaoyong , Jensen Lars Juhl , Gorodkin Jan 
Published: October 2018

AbstractMotivationLong non-coding RNAs (lncRNAs) are important regulators in wide variety of biological processes, which are linked to many diseases. Compared to protein-coding genes (PCGs), the association between diseases and lncRNAs is still not well studied. Thus, inferring disease-associated lncRNAs on a genome-wide scale has become imperative.ResultsIn this study, we propose a machine learning-based method, DislncRF, which infers disease-associated lncRNAs on a genome-wide scale based on tissue expression profiles. DislncRF uses random forest models trained on expression profiles of known disease-associated PCGs across human tissues to extract general patterns between expression profiles and diseases. These models are then applied to score associations between lncRNAs and diseases. DislncRF was benchmarked against a gold standard dataset and compared to other methods. The results show that DislncRF yields promising performance and outperforms the existing methods. The utility of DislncRF is further substantiated on two diseases in which we find that top scoring candidates are supported by literature or independent datasets.Availability and implementationhttps://github.com/xypan1232/DislncRFSupplementary informationSupplementary data are available at Bioinformatics online.
Contraceptive drugs mitigate experimental stroke-induced brain injury
Authors: El Amki Mohamad , Binder Nadine , Steffen Riccardo , Schneider Hannah , Luft Andreas R , Weller Michael , Imthurn Bruno , Merki-Feld Gabriele S , Wegener Susanne 
Published: October 2018

AbstractAimsEffective stroke treatments beyond reperfusion remain scant. The natural steroid hormone progesterone has shown protective effects in experimental models of brain injury and cardiovascular disease. However, unfavourable bioavailability limits its clinical use. Desogestrel and drospirenone are new generation progestins with progesterone-like properties, developed as oral contraceptives with excellent bioavailability and safety profile. We investigated the neuroprotective properties of these progestins in vivo using transient middle cerebral artery occlusion (MCAO) and in vitro using an oxygen-glucose deprivation and reoxygenation (OGD/R) model in primary neuronal cells.Methods and resultsMCAO was induced in female, female ovariectomized (modelling postmenopausal females) and male mice. Treatment with the progestins resulted in less severe strokes after MCAO and less neuronal death in OGD/R. Desogestrel and drospirenone induced higher expression levels of GABAAR α4 and delta subunits within the brain, suggesting changes in GABAAR configuration favouring tonic inhibition as potential mechanism of action. Treatment with the GABAAR blocker picrotoxin abolished the protection afforded by the progestins in vivo and in vitro.ConclusionFor the first time, here, we delineate a potential role of desogestrel and drospirenone, both clinically approved and safe drugs in mitigating the consequences of stroke. Contraception with desogestrel and drospirenone in progestin-only preparations may be particularly beneficial for women at risk of stroke.
Additional appointments and discomfort associated with compliance-free fixed Class II corrector treatment: a systematic review
Authors: Phuong Ashley , Fagundes Nathalia Carolina Fernandes , Abtahi Sahar , Roberts Mary Roduta , Major Paul W , Flores-Mir Carlos 
Published: October 2018

SummaryObjectiveA critical analysis of the literature to determine the prevalence and type of emergency/additional appointments, and discomfort levels associated with fixed Class II correctors.MethodsStudies examining patient’s sources of discomfort or emergency appointments associated with compliance-free Class II correctors were included. Comprehensive searches up to July 2018 were conducted using the following databases: MEDLINE (OvidSP), PubMed, Web of Science, and Embase. A partial grey literature search was taken using Google Scholar and OpenGrey. Two reviewers independently performed the selection process and risk of bias assessment. The Newcastle-Ottawa Scale for cross-sectional studies were used. A summary of the overall strength of evidence was presented using ‘Grading of Recommendations, Assessment, Development and Evaluation’ (GRADE) tool. Included studies were evaluated according to their design, study quality, consistency, and directness.ResultsThe selected studies were published between 2001 and 2018, and the number of patients per studied group ranged from 8 to 182. One thousand five hundred forty-two patients were evaluated in total. The patients’ mean age at start of treatment ranged from 10 to 16.9 years and the fixed Class II corrector treatment duration ranged from 4 to 12 months. The included studies in this systematic review were too clinically heterogeneous (different appliances, different data recollection processes) to justify a meta-analysis.LimitationsThis review was not previously registered. A low level of evidence was observed among the two randomized trials, the 10 cohorts and three cross-sectional studies identified.ConclusionsThe main source of discomfort from Forsus-type appliances appears to be soreness in the cheeks (low level of evidence with a weak recommendation strength). Most evaluated patients treated with a Herbst appliance, regardless of design, will experience complications (fractures and/or dislodging) requiring emergency appointments (low level of evidence with a weak recommendation strength).RegistrationThe review protocol was not registered.
An exact penalty method for semidefinite-box-constrained low-rank matrix optimization problems
Authors: Liu Tianxiang , Lu Zhaosong , Chen Xiaojun , Dai Yu-Hong 
Published: October 2018

AbstractThis paper considers a matrix optimization problem where the objective function is continuously differentiable and the constraints involve a semidefinite-box constraint and a rank constraint. We first replace the rank constraint by adding a non-Lipschitz penalty function in the objective and prove that this penalty problem is exact with respect to the original problem. Next, for the penalty problem we present a nonmonotone proximal gradient (NPG) algorithm whose subproblem can be solved by Newton’s method with globally quadratic convergence. We also prove the convergence of the NPG algorithm to a first-order stationary point of the penalty problem. Furthermore, based on the NPG algorithm, we propose an adaptive penalty method (APM) for solving the original problem. Finally, the efficiency of an APM is shown via numerical experiments for the sensor network localization problem and the nearest low-rank correlation matrix problem.
Topological Moduli Space for Germs of Holomorphic Foliations
Authors: Marín David , Mattei Jean-François , Salem Éliane 
Published: October 2018

Abstract
This work deals with the topological classification of germs of singular foliations on $(\mathbb{C}^{2},0)$. Working in a suitable class of foliations we fix the topological invariants given by the separatrix set, the Camacho–Sad indices, and the projective holonomy representations and we compute the moduli space of topological classes in terms of the cohomology of a new algebraic object that we call group-graph. This moduli space may be an infinite-dimensional functional space but under generic conditions we prove that it has finite dimension and we describe its algebraic and topological structure.
Mesenchymal Stem Cell-Seeded High-Density Collagen Gel for Annular Repair: 6-Week Results From In Vivo Sheep Models
Authors: Hussain Ibrahim , Sloan Stephen R , Wipplinger Christoph , Navarro-Ramirez Rodrigo , Zubkov Micaella , Kim Eliana , Kirnaz Sertac , Bonassar Lawrence J , Härtl Roger 
Published: October 2018

Abstract

BACKGROUND
Our group has previously demonstrated in vivo annulus fibrosus repair in animal models using an acellular, riboflavin crosslinked, high-density collagen (HDC) gel.

OBJECTIVE
To assess if seeding allogenic mesenchymal stem cells (MSCs) into this gel yields improved histological and radiographic benefits in an in vivo sheep model of annular injury.

METHODS
Fifteen lumbar intervertebral discs (IVDs) were randomized into 4 groups: intact, injury only, injury + acellular gel treatment, or injury + MSC-seeded gel treatment. Sheep were sacrificed at 6 wk. Disc height index (DHI), Pfirrmann grade, nucleus pulposus area, and T2 relaxation time (T2-RT) were calculated for each IVD and standardized to healthy controls from the same sheep. Quantitative histological assessment was also performed using the Han scoring system.

RESULTS
All treated IVDs retained gel plugs on gross assessment and there were no adverse perioperative complications. The MSC-seeded gel treatment group demonstrated statistically significant improvement over other experimental groups in DHI (P = .002), Pfirrmann grade (P < .001), and T2-RT (P = .015). There was a trend for greater Han scores in the MSC-seeded gel-treated discs compared with injury only and acellular gel-treated IVDs (P = .246).

CONCLUSION
MSC-seeded HDC gel can be delivered into injured IVDs and maintained safely in live sheep to 6 wk. Compared with no treatment and acellular HDC gel, our data show that MSC-seeded HDC gel improves outcomes in DHI, Pfirrmann grade, and T2-RT. Histological analysis shows improved annulus fibrosus and nucleus pulposus reconstitution and organization over other experimental groups as well.