bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Submerged Resilience
Authors: Reinhardt Bob H 
Published: December 2024

Abstract
Submerged under the reservoirs for large dams lie the remains of displaced communities that reveal the depths of “resilience.” Exploring the histories of such places brings to the surface not only a wide spectrum of resistance (the most common yet most limited definition of “resilience”) but also resilience in two forms: (1) an insistence on the value of inundated communities and the perspectives of people who call them home, and (2) the persistence of such places and people. These ideas have emerged out of the Atlas of Drowned Towns (drownedtowns.com). This digital public history project creates processes and spaces in which communities affected by dam-induced displacement can participate in finding, remembering, and making sense of the histories of such places. Currently under development with a focus on thirteen dams in Oregon’s Willamette Valley, the project’s processes include community outreach, engagement, and archiving events called “History Jamborees,” which help build a digital archive that contributes to the Atlas’s website. The artifacts, stories, and memories shared with the Atlas of Drowned Towns reveal acts of resistance, insistence, and persistence in the past, and those acts of sharing and participation themselves provide opportunities to express and define resilience in the present.
The Lancashire Plague Petitions
Authors: Anderson Rachel 
Published: December 2024

Abstract
Historians typically explore the resilience of past societies in terms of large-scale outcomes like population levels. In contrast, this paper explores the process of recovering from outbreaks of plague in smaller communities, households, and even by individuals. In doing so, it examines resilience on a micro-level in terms of the economic, emotional, and practical concerns of individuals following a period of crisis. This paper showcases six early modern petitions, each transcribed here in full, providing insight into the responses of communities to severe outbreaks of epidemic disease. These sources reveal the practical measures required to foster resilience: each petition demonstrates a series of unique needs and essential interventions. The usual systems of relief proved inadequate when faced with the unprecedented demands of plague. This made the bonds between friends and neighbors crucial to the survival of their communities. Only when these bonds were pushed to their breaking point did early modern people turn to authorities. These petitions show us when and why those points were reached.
Ecologies of Resilience
Authors: Cushman Gregory T , Jackson Trisha , Feddema Johannes J 
Published: December 2024

Abstract
The history of Rapa Nui has often been told as a cautionary tale meant to reflect on the destructive tendencies of our own civilization, but it looks quite different when told from a Rapanui perspective. This interdisciplinary study uses new source materials to explore an extraordinary story of Native resilience: seldom-used oral histories from Rapanui elders from the 1910s, a Rapanui-language account of its original settlement, and a newly reconstructed Rapanui Chronology of Years, as well as the latest physical data of environmental change on the island, reconstructions of the ancient night sky, and an innovative model of the historical productivity of traditional crops. They reveal the exact stars and winds the ancient Rapanui followed to locate this island originally; their embrace of new crop varieties, animals, and cultivation methods to ensure their subsistence; and their vulnerability to severe droughts and climate change. Rapanui resilience experienced its greatest test during the 1860s and 1870s when interethnic conflict, a punishing La Niña drought, introduced diseases, plantation enslavement, Catholic missionization, and colonization by outsiders struck the island in waves. But Rapanui elders remembered these events as much for their tenacious resistance and resilience to these challenges as for their tragic loss.
Evaluating the potential for iodinated radiocontrast agents to interfere with ADAMTS13 activity testing via fluorescence resonance energy transfer methodology
Authors: Jacobs Jeremy W , Stuart Melissa S , Tange Julie I , Leger Rachel R , Ashrani Aneel A , Chen Dong , Pruthi Rajiv K , Sridharan Meera , Seheult Jansen N 
Published: December 2024

Abstract

Objectives
Fluorescence resonance energy transfer (FRET)–based ADAMTS13 activity assays are critical for the diagnosis of thrombotic thrombocytopenic purpura. However, these assays are susceptible to interference. As iodide has been suggested to interfere in laboratory testing via fluorophore quenching or promotion, we aimed to determine whether iodinated contrast (Omnipaque) interferes with the ATS-13 ADAMTS13 Activity Assay 2.0.

Methods
We evaluated the excitation, emission, and absorbance spectrum of Omnipaque alone and spiked in patient plasma with known ADAMTS13 activity and ADAMTS13 activity on Omnipaque alone, an abnormal control of patient plasma previously observed to display elevated baseline relative fluorescent units, and variable concentrations of patient plasma with known ADAMTS13 activity spiked with Omnipaque.

Results
No atypical fluorescent peaks were observed on any sample (Omnipaque alone or spiked in plasma) between 250 and 700 nm. There was no difference in the mean ADAMTS13 activity among the various concentrations of plasma spiked with Omnipaque or plasma spiked with saline.

Conclusions
Iodinated contrast does not appear to interfere—either via spectral overlap of the fluorophore or through physiologic inhibition of the ADAMTS13 enzyme—with ADAMTS13 activity FRET-based assays based on the findings from this in vitro analysis. Delaying sample collection for ADAMTS13 activity testing from suspected patients with thrombotic thrombocytopenic purpura following administration of iodinated radiocontrast agents is not necessary, and recent contrast administration should not yield erroneous ADAMTS13 activity results.
Dietary copper, zinc, copper/zinc ratio intakes and irritable bowel syndrome risk: a large-scale prospective cohort study from UK Biobank
Authors: Zhuang Yan , Li Laifu , Ran Yan , Zhang Yanqi , Chen Jiamiao , Liu Xuna , Zeng Beibei , Zhu Boxu , Dai Fei 
Published: December 2024

Abstract
Studies have suggested that dietary copper and zinc intakes may be associated with irritable bowel syndrome (IBS), however, prospective evidence is lacking. This study aimed to prospectively investigate the relationship between dietary copper, zinc, and copper/zinc (Cu/Zn) ratio intakes and the development of IBS in a long-term cohort. A total of 175,421 participants in the UK Biobank without IBS at baseline were included. Dietary intake was assessed by the Oxford WebQ. New-onset IBS was identified using ICD-10 codes (K58). Cox proportional hazard models were applied. During a median follow-up of 13.3 years, 2240 individuals were newly diagnosed with IBS. Copper, zinc, and Cu/Zn ratio intakes all showed U-shaped relationships with IBS incidence. When copper intake &lt;1.5 mg/day and zinc intake &lt;10 mg/day, the risk of IBS significantly decreased with increasing copper and zinc intakes [HR copper (95%CI), 0.791(0.647,0.967); HR zinc (95%CI), 0.967(0.937,0.998)]. No significant association was found when copper intake ≥1.5 mg/day and zinc intake ≥10 mg/day. Subgroup analysis suggested a moderate increase in zinc intake was more helpful for preventing IBS in &lt; 60-year-old participants. Moderately increasing dietary zinc intake and maintaining dietary copper and Cu/Zn ratio in a reasonable range is beneficial in reducing IBS incidence.
Relationship between medication regimen complexity and pharmacist engagement in fluid stewardship
Authors: Smith Susan E , Smith Logan T , Sikora Andrea , Branan Trisha N , Bland Christopher M , Hawkins W Anthony 
Published: December 2024

Abstract

Purpose
The medication regimen complexity intensive care unit (MRC-ICU) score has previously been associated with pharmacist workload and fluid overload. The purpose of this study was to determine the relationship of MRC-ICU score with pharmacist-driven fluid stewardship recommendations as a means of establishing its role in risk stratifying critically ill patients for pharmacist intervention.

Methods
Adult patients admitted to the medical ICU and followed by the academic pharmacy team were included in this retrospective, single-center cohort study. Patient and pharmacist data were collected via electronic medical record and surveillance tool, respectively. MRC-ICU and sequential organ failure assessment (SOFA) scores were captured at ICU admission. The primary outcome was correlation between MRC-ICU score and number of pharmacist-driven fluid stewardship recommendations. Secondary outcomes included the relationships between MRC-ICU score, accepted recommendations, and patient outcomes (fluid overload and length of stay [LOS]). Descriptive statistics were calculated for each variable. Spearman’s rank-order correlation was used.

Results
Of 168 patients, 22 (13%) experienced fluid overload. Median MRC-ICU and SOFA scores were 13 and 7, respectively, and were higher for patients experiencing fluid overload than for those without fluid overload. MRC-ICU had a weakly positive correlation with the number of pharmacist-driven fluid stewardship recommendations (ρ = 0.200; P = 0.010), fluid overload (ρ = 0.167; P = 0.030), and ICU LOS (ρ = 0.354; P &lt; 0.001). These relationships remained true when looking at only the fluid stewardship recommendations that were accepted by the team.

Conclusion
MRC-ICU displayed a weakly positive correlation with pharmacist workload, suggesting its potential use in identifying patients likely to benefit from pharmacist intervention.
Medication administration by inpatient pharmacists: Innovative interdisciplinary care teams
Authors: Boothby Lisa , Webb Emily , Goodlett Deborah , Brown Kellee , Odinet Johlee 
Published: December 2024

Abstract

Purpose
Pharmacists traditionally provide clinical pharmacy services in acute care settings. Two hospitals within our system integrated medication administration pharmacists into inpatient interdisciplinary care teams. Goals of this interdisciplinary care model were to improve productivity, quality, safety, patient satisfaction, and team member engagement while decreasing waste in the medication-use process and reliance on external nursing agency support.

Summary
The new pharmacy role of medication administration pharmacist (MAP pharmacist) was integrated into the inpatient interdisciplinary care team. This new pharmacy role was not responsible for order verification in the electronic medical record. MAP pharmacists administered 99% of medications for assigned patients, averaging 100 to 120 medication administrations per day. Pharmacists educated patients about medications, including their purpose and most common adverse effects, using the teach-back method. Patient satisfaction scores increased 37% for patients’ ability to understand adverse effects of medications and 44% for understanding the purpose of their new medications. Annual nursing staff turnover decreased from 30% to 7%, with a $2 million decrease in external nurse agency spend from 2022 to 2023. Pharmacist team member satisfaction scores, as measured on a Press Ganey scale ranging from 1 (poor) to 5 (very good), remained high, at a mean of 4.00 for engagement, with “progress,” “quality work, and “knows what is expected” cited as strengths (mean scores of 4.23-4.46). The mean Press-Ganey score for pharmacy well-being increased from 3.80 in 2022 to 3.99 in 2023. Pharmacy opportunities identified via survey include enhanced communication and continued professional development. Post implementation, all surveyed nurses requested medication administration pharmacists on the inpatient interdisciplinary care team moving forward.

Conclusion
The interdisciplinary care team with pharmacists enhanced medication safety and quality indicators, improved nursing satisfaction with workflow, and had a positive impact on patient satisfaction. Increased nursing capacity allowed for expanded assignments and nurse-to-patient ratios, as well as decreased reliance on external nurse agency support. Due to the overwhelming success of the initiative, MAP pharmacists’ role as part of the interdisciplinary care team is being expanded to additional hospital service lines throughout the healthcare system.
Temperature and plant-available soil phosphorus drive intraspecific variation in plant economic traits of Schima superba across an elevation gradient
Authors: Li Jinlong , Westerband Andrea C , Wright Ian J , Li Xueqin , Du Jingui , Zhong Quanlin , Hu Dandan , Cheng Dongliang 
Published: December 2024

Abstract

Background and Aims
The whole-plant economics spectrum describes coordination between organ-level traits that together determine resource-use strategies and is relevant for understanding plant responses to environmental change. Although coordination between organs has been explored previously across species, it remains unclear whether patterns observed across species hold within species. In addition, the key driving forces underlying this coordination warrant clarification.

Methods
In this study, we used univariate (regression analysis) and multivariate (principal components analysis and network analysis) analyses to investigate the environmental drivers of intraspecific trait variation and, consequently, trait covariation, focusing on leaf and fine root traits. We sampled 60 individuals of Schima superba, a widespread evergreen tree, across five elevations in a subtropical forest in China, measuring traits associated with resource use and capture, including photosynthesis, specific root length and root diameter.

Key Results
Leaf and root traits were significantly correlated within species, forming a whole-plant economics spectrum. We found that plants at low and high elevations had more resource-acquisitive traits than at intermediate elevation. Notably, leaf and root traits, in addition to a composite variable that contained both, varied non-linearly with elevation. Leaf trait variation was driven primarily by temperature, whereas root trait variation and a composite variable containing leaf and root traits were most strongly influenced by temperature and plant-available soil phosphorus.

Conclusions
Our findings show that the coordinated responses of individual traits to climate and soil properties underlie intraspecific variation in whole-plant resource-use strategies across environmental gradients. These findings are contrary to recent studies that have found evidence of decoupling between above- and below-ground traits, which suggests that there is selection for coordination among traits in S. superba. Thus, our study enhances our understanding of the key drivers and the ecological significance of environmentally driven intraspecific trait variation.
‘We can fix this. Let’s get you out of trouble, son’: an analysis of the transitivity and appraisal patterns in the Netflix TV show When They See Us
Authors: Bartley Leanne , Trevisan Piergiorgio 
Published: December 2024

Abstract
The fascination with crime, as evident from its extensive coverage in novels and on television, remains a topic of interest for the general public. This fascination often elicits responses rooted in deeply held values and can significantly impact individuals. Consequently, people’s attitudes toward interrogations, trials, and punishments may be strongly influenced by the discourse surrounding crime as portrayed in fictional texts. The primary objective of this article is to contribute to the body of research that has delved into the influential role of ideology in shaping narratives centred on crime stories. Specifically, through a linguistic analysis of transitivity and appraisal patterns in the first episode of the TV series When They See Us, this study addresses two fundamental research questions: 1) What does a transitivity analysis of process and participant types reveal about the construction of ‘a criminal character’ and how may this contribute to a presupposition of guilt? 2) What can an Appraisal analysis tell us about the evaluative portrayal of ‘a criminal character’ and how may this contribute to a presupposition of guilt? The aim is to provide insights into how the discursive representation of specific social groups, exemplified here by black Hispanic teenagers, simultaneously reflects and influences public perceptions, particularly when the discourse emanates from authoritative figures.
Quantitative analysis of sterol balance in a mouse model of hepatic lipid accumulation induced by cholesterol and cholic acid supplementation
Authors: Soma Hinata , Yoshida Ryo , Ishizuka Satoshi 
Published: December 2024

Abstract
The cholesterol balance and bile acid metabolism in a mouse model of hepatic lipid accumulation induced by a diet supplemented with cholesterol and cholic acid (CA) were quantitatively evaluated. The mice were fed diets supplemented with different levels of cholesterol (0, 3, or 6 g/kg of diet) and CA (0.5 g/kg of diet) for 6 weeks. Cholesterol supplementation doubled the hepatic triglyceride concentration, regardless of the supplementation level, without inflammation or gallstone formation. Both cholesterol supplementations enhanced fecal excretion of muricholic acid. Additionally, the higher cholesterol supplementation led to an increase in fecal cholesterol excretion, accompanied by elevated expression of hepatic cholesterol exporters and a reduction in fecal bile acid excretion. In this mouse study, supplementation with 3 g cholesterol/kg diet and 0.5 g CA/kg diet was sufficient to induce hepatic lipid accumulation.
Thermal biology of the endemic lizard Phymaturus verdugo: is it as conservative as we think?
Authors: Moreno Azocar Débora L , Vicenzi Nadia , Literas Sofía , Corbalán Valeria 
Published: December 2024

Abstract
Under the scenario of global climate change, understanding how animals cope with environmental changes might help to predict their future responses. The genus Phymaturus serves as a valuable model for studying thermal biology owing to its conservatism in thermal traits, despite its broad latitudinal distribution. By examining two geographically close populations of the lizard Phymaturus verdugo from the Andean mountains, we aimed to determine whether body mass, dorsal melanism, and microclimatic conditions influence their thermal biology. The species demonstrates moderate to good thermoregulation, with females increasing effectiveness in sites with lower thermal quality. Although their preferred temperature remained consistent across populations, significant differences in body temperature, effectiveness of thermoregulation, and heating times were observed. Melanism, proposed to enhance heating in cold environments, showed limited effects on thermoregulation, accelerating heating times only in specific conditions (males heating from 15°C to 35°C at the colder site). Instead, body mass emerged as the key factor that consistently slowed heating times. Our findings suggest that P. verdugo relies heavily on behavioural strategies for thermoregulation, allowing individuals to cope with immediate thermal variability, but the ability to adapt to future climate change remains uncertain, because these responses might provide short-term benefits but limit long-term physiological adaptation.
Estimating marginal treatment effect in cluster randomized trials with multi-level missing outcomes
Authors: Chang Chia-Rui , Wang Rui 
Published: December 2024

ABSTRACT
Analyses of cluster randomized trials (CRTs) can be complicated by informative missing outcome data. Methods such as inverse probability weighted generalized estimating equations have been proposed to account for informative missingness by weighing the observed individual outcome data in each cluster. These existing methods have focused on settings where missingness occurs at the individual level and each cluster has partially or fully observed individual outcomes. In the presence of missing clusters, for example, all outcomes from a cluster are missing due to drop-out of the cluster, these approaches ignore this cluster-level missingness and can lead to biased inference if the cluster-level missingness is informative. Informative missingness at multiple levels can also occur in CRTs with a multi-level structure where study participants are nested in subclusters such as healthcare providers, and the subclusters are nested in clusters such as clinics. In this paper, we propose new estimators for estimating the marginal treatment effect in CRTs accounting for missing outcome data at multiple levels based on weighted generalized estimating equations. We show that the proposed multi-level multiply robust estimator is consistent and asymptotically normally distributed provided that one of the multiple propensity score models postulated at each clustering level is correctly specified. We evaluate the performance of the proposed method through extensive simulations and illustrate its use with a CRT evaluating a Malaria risk-reduction intervention in rural Madagascar.
Polyploids and geographic divergence blur species delimitation in the Paspalum stellatum complex (Poaceae: Paspaleae)
Authors: Bonasora Marisa G , López Méndez Alicia , Speranza Pablo R , Honfi Ana I , Rua Gabriel H 
Published: December 2024

Abstract
Paspalum stellatum comprises a diploid and several polyploid cytotypes. The widely distributed cytotype 2n = 32 is an amphidiploid, an outcome of hybridization between diploid P. stellatum (2n = 20) and the related species Paspalum schesslii (2n = 12). Several analyses were conducted upon a set of 24 accessions of P. stellatum and representatives of three related species. Multivariate analyses of morphological data discriminated between the two potentially sexual cytotypes, 2n = 20 and 2n = 32, but the putatively apomictic higher polyploids were interspersed between them. Instead, Iner Simple Sequence Repeat (ISSR) markers separate two main groups geographically, west and east from the Brazilian-Bolivian Pantanal. Both groups include diploid (2n = 20) and tetraploid (2n = 32) cytotypes, but higher polyploids belong exclusively to the eastern group. Considering that diploids and polyploids behave as different biological entities, we propose to treat the diploid (2n = 20) cytotype as a different species, for which the name Paspalum cujabense should be rehabilitated. Meanwhile, the name P. stellatum remains for a complex including the tetraploid and all polyploid cytotypes.