bluuebunny/crossref_metadata_2025_split huggingface dataset:
2D Binary Plasmonic Nanoassemblies with Semiconductor n/p‐Doping‐Like Properties
Authors: Shi Qianqian , Sikdar Debabrata , Fu Runfang , Si Kae Jye , Dong Dashen , Liu Yiyi , Premaratne Malin , Cheng Wenlong 
Published: May 2018

AbstractThe electronic, optical, thermal, and magnetic properties of an extrinsic bulk semiconductor can be finely tuned by adjusting its dopant concentration. Here, it is demonstrated that such a doping concept can be extended to plasmonic nanomaterials. Using two‐dimensional (2D) assemblies of Au@Ag and Au nanocubes (NCs) as a model system, detailed experimental and theoretical studies are carried out, which reveal collective semiconductor n/p‐doping‐like plasmonic properties. A threshold doping concentration of Au@Ag NCs is observed, below which p‐doping dominates and above which n‐doping prevails. Furthermore, Au@Ag NC dopants can be converted into corresponding Au seed “voids” dopants by selectively removing Ag without changing the overall structural integrity. The results show that the plasmonic doping concept may serve as a general design principle guiding synthesis and assembly of plasmonic metamaterials for programmable optoelectronic devices.
The Cucurbit[7]Uril‐Based Supramolecular Chemistry for Reversible B/Z‐DNA Transition
Authors: Wang Shao‐Ru , Wang Jia‐Qi , Xu Guo‐Hua , Wei Lai , Fu Bo‐Shi , Wu Ling‐Yu , Song Yan‐Yan , Yang Xi‐Ran , Li Conggang , Liu Si‐Min , Zhou Xiang 
Published: May 2018

AbstractAs a left‐handed helical structure, Z‐DNA is biologically active and it may be correlated with transcription and genome stability. Until recently, it remained a significant challenge to control the B/Z‐DNA transition under physiological conditions. The current study represents the first to reversibly control B/Z‐DNA transition using cucurbit[7]uril‐based supramolecular approach. It is demonstrated that cucurbit[7]uril can encapsulate the central butanediamine moiety [HN(CH2)4NH] and reverses Z‐DNA caused by spermine back to B‐DNA. The subsequent treatment with 1‐adamantanamine disassembles the cucurbit[7]uril/spermine complex and readily induces reconversion of B‐ into Z‐DNA. The DNA conformational change is unequivocally demonstrated using different independent methods. Direct evidence for supramolecular interactions involved in DNA conformational changes is further provided. These findings can therefore open a new route to control DNA helical structure in a reversible way.
A Highly Efficient Synthesis of Polyubiquitin Chains
Authors: Qu Qian , Pan Man , Gao Shuai , Zheng Qing‐Yun , Yu Yuan‐Yuan , Su Jia‐Can , Li Xiang , Hu Hong‐Gang 
Published: May 2018

AbstractA robust, microwave‐assisted, highly efficient, solid‐phase peptide synthesis method for preparing isopeptide‐linked 62‐mer and 76‐mer isoubiquitins and polyubiquitin is developed. The strategy avoids the use of costly resins and pseudoprolines, and the isopeptide‐linked building blocks can be assembled with high initial purity within 1 day. All seven diubiquitins are successfully synthesized on a multi‐milligram scale; a four‐segment, three‐ligation method is used to obtain a K33‐/K11‐linked mixed triubiquitin in excellent yield. Circular dichroism and crystallographic analyses are used to verify the structures of the well‐folded, synthetic polyubiquitin chains. The facile synthetic strategy is expected to be generally applicable for the rapid synthesis of isopeptide‐linked isoUbs and to pave the way for the study of longer polyubiquitin chains.
Galvanic Displacement Synthesis of Monodisperse Janus‐ and Satellite‐Like Plasmonic–Magnetic Ag–Fe@Fe3O4 Heterostructures with Reduced Cytotoxicity
Authors: Zhang Huilin , Yang Ziyu , Ju Yanmin , Chu Xin , Ding Ya , Huang Xiaoxiao , Zhu Kai , Tang Tianyu , Su Xintai , Hou Yanglong 
Published: May 2018

AbstractThe unique physicochemical properties of silver nanoparticles offer a large potential for biomedical application, however, the serious biotoxicity restricts their usage. Herein, nanogalvanic couple Ag–Fe@Fe3O4 heterostructures (AFHs) are designed to prevent Ag+ release from the cathodic Ag by sacrificial anodic Fe, which can reduce the cytotoxicity of Ag. AFHs are synthesized with modified galvanic displacement strategy in nonaqueous solution. To eliminate the restriction of lattice mismatch between Fe and Ag, amorphous Fe@Fe3O4 nanoparticles (NPs) are selected as seeds, meanwhile, reductive Fe can reduce Ag precursor directly even at as low as 20 °C without additional reductant. The thickness of the Fe3O4 shell can influence the amorphous properties of AFHs, and a series of Janus‐ and satellite‐like AFHs are synthesized. A “cut‐off thickness” effect is proposed based on the abnormal phenomenon that with the increase of reaction temperature, the diameter of Ag in AFHs decreases. Because of the interphase interaction and the coupling effect of Ag and Fe@Fe3O4, the AFHs exhibit unique optical and magnetic properties. This strategy for synthesis of monodisperse heterostructures can be extended for other metals, such as Au and Cu.
Iron‐Catalyzed Directed C−H Silylation of Pivalophenone N−H Imines
Authors: Xu Wengang , Pek Jie Hui , Yoshikai Naohiko 
Published: May 2018

AbstractAn iron‐catalyzed, N−H imine‐directed arene C−H silylation reaction with hydrosilane has been achieved. Pivalophenone N−H imine undergoes ortho C−H silylation with triethylsilane in the presence of [Fe3(CO)12] as a catalyst and norbornene as a hydrogen acceptor. The product can be readily transformed into ortho‐silylated benzonitrile via conversion of the imine functionality to a cyano group under peroxide photolysis.
Von isolierten Ionen zu mehrschichtigen funktionellen Materialien durch sanfte Landung von Ionen
Authors: Laskin Julia , Johnson Grant E. , Warneke Jonas , Prabhakaran Venkateshkumar 
Published: May 2018

AbstractDie Fähigkeit, mehratomige Ionen, bei denen Aufbau, Ladungszustand und kinetische Energie wohldefiniert sind, auf Oberflächen aufzutragen, macht die präparative Massenspektrometrie, auch “sanfte Landung von Ionen” (SLI) genannt, attraktiv für die Herstellung einheitlicher Molekül‐ und Ionenschichten. Nachdem in frühen Studien die Strukturen, Ladungszustände und Reaktivitäten von dünn verteilten, sanft gelandeten Arten charakterisiert wurden, haben Ionisationsquellen mit hohem Durchsatz neue Möglichkeiten eröffnet für die kontrollierte Herstellung zweidimensionaler Anordnungen und dreidimensionaler mehrschichtiger Gebilde durch SLI. Dadurch wurden zuvor unbekannte Phänomene entdeckt und aufregende neue Forschungsrichtungen eröffnet. Das schnellere Ablagern ermöglicht darüber hinaus die Herstellung von neuen funktionalen Objekten. Dieser Aufsatz diskutiert Entwicklungen in Bezug auf die Präparation wohldefinierter Schnittstellen für Studien zur Energiespeicherung, Katalyse, weiche Materialien und Biologie.
Rheological and physical characterization of pressure sensitive adhesives from bio‐derived block copolymers
Authors: Sotoodeh‐Nia Zahra , Hohmann Austin , Buss Ashley , Williams R. Christopher , Cochran Eric W. 
Published: May 2018

ABSTRACTOver the past decade, the development of various monomers and polymeric materials from renewable natural resources has received increasing attention. Soybean oil, as one of the most abundant vegetable oils, has been widely used in recent studies. To enhance the reactivity of pure soybean oil, it can undergo through different processes such as acrylation and epoxidation. In this article, we investigated the viability of polymerized acrylated epoxidized soybean oil (PAESO) in the composition of pressure sensitive adhesives (PSAs). We studied the physical and rheological properties of PSAs composed of poly(styrene‐b‐AESO), and five different tackifiers and three plasticizers. To verify the compatibility of the tackifiers with the biopolymer, a library of 15 PSAs was prepared through solvent blending method and tested by differential scanning calorimetry. The viable formulations were then prepared through hot‐melt blending and characterized using 180° peel tester, and advanced rheometric expansion system. Results showed that the combination of an ester of hydrogenated rosin and a high solvating plasticizer with the synthesized biopolymer indicated best performance relative to other formulations. The comparison of this candidate with its petroleum‐based counterpart containing SIS demonstrates promising potential of the material to perform as well as commercialized PSAs. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46618.
Effects of whale watching on the activity budgets of humpback whales,Megaptera novaeangliae(Borowski, 1781), on a feeding ground
Authors: Di Clemente Jacopo , Christiansen Fredrik , Pirotta Enrico , Steckler Dave , Wahlberg Magnus , Pearson Heidi Christine 
Published: May 2018

AbstractWhale watching can affect cetacean behaviour, and can in some cases lead to long‐term negative effects on survival and reproduction.The waters of Juneau (Alaska) represent a summer feeding ground for the Central North Pacific stock of humpback whales,Megaptera novaeangliae(Borowski, 1781). The recent dramatic expansion of the local whale‐watching industry has raised concerns over the potential negative impact of such activity on the whales.The aim of this study was to understand the impact of whale‐watching vessels on humpback whale behaviour in Juneau. From June to September 2015, land‐based observations were conducted to record whale behaviour in the presence and absence of vessels.Markov chains and model simulations showed that the presence of vessels was not associated with a reduction in the time spent feeding. Whales exhibited more surface‐active behaviour and travelled less in the presence of vessels.The lack of an overt response of feeding whales to whale‐watching disturbance could result from the importance of the Southeast Alaska study region as a feeding ground, which could make the whales less apt to interrupt feeding under disturbance; however, The high proportion of travelling observed may indicate that the study area represents a travelling corridor between other, localized feeding areas. The increase in surface‐active behaviour may represent a response to vessel presence that could potentially lead to energetic consequences.The large number of whale‐watching vessels operating could lead to the increased tolerance of whales towards whale‐watching activities. The lack of responses in this study may suggest that the reactions of whales are context specific, depending on their previous experience with vessels and their foraging behaviour, for example. Subtler negative effects could still occur, however, and a prolonged monitoring programme is required to assess less overt behavioural responses of whales over time.
Realisierung der Großen Moschee von Algerien
Authors: Akkermann Jan , Bastian Kévin , Bouthiba Abderrahmane , Fischer Eric 
Published: May 2018

AbstractIn Algier nähert sich der Rohbau der Großen Moschee von Algerien der Fertigstellung. Die drittgrößte Moschee der Welt erhält das mit einer Bauhöhe von 265 m weltweit höchste Minarett, welches gleichzeitig das höchste Gebäude des afrikanischen Kontinents sein wird. Das architektonische Wahrzeichen bedingte ein Höchstmaß von Anforderungen an die Baumaterialen und die nachhaltige Tragwerksintegrität. Der Entwurf berücksichtigte bereits die im Artikel beschriebenen außergewöhnlichen Bauprozesse der Megabaustelle.
Energy security role of biofuels in evolving liquid fuel markets
Authors: Uría‐Martínez Rocío , Leiby Paul N. , Brown Maxwell L. 
Published: May 2018

AbstractWe explore the role of biofuels in mitigating the negative impacts of oil supply shocks on fuel markets under a range of oil price trajectories and biofuel blending mandate levels. Using a partial equilibrium model of US biofuels production and petroleum fuels trade, we discuss the adjustments in light‐duty vehicle fuel mix, fuel prices, and renewable identification number (RIN) prices following each shock as well as the distribution of shock costs across market participants. Ethanol is used as both a complement (blend component in E10) and a substitute (in E15 and E85 blends) to gasoline. Results show that, during oil supply shocks, the role of ethanol as a substitute dominates and allows some mitigation of the shock. As US petroleum imports decrease with growing US oil production, the net economic welfare effect of sudden oil price changes and the energy security role of biofuels becomes less clear than it has been in the past. Although fuel consumers lose when oil price increases due to an external shock, domestic fuel producers gain. In some cases, depending on import share and supply and demand elasticities, we show that the gain to producers could more than offset consumer losses. However, in most cases evaluated here, sudden oil‐price increases remain costly. © 2018 Society of Chemical Industry and John Wiley & Sons, Ltd
Women's periconceptional diet and risk of biliary atresia in offspring
Authors: Carmichael Suzan L. , Ma Chen , Van Zutphen Alissa R. , Moore Cynthia A. , Shaw Gary M. ,   the National Birth Defects Prevention Study
Published: May 2018

IntroductionWe examined the association of biliary atresia with maternal dietary intake, using National Birth Defects Prevention Study (NBDPS) data from 152 cases and 11,112 nonmalformed controls born 1997–2011.MethodsNBDPS is a multisite, population‐based case‐control study. Exposure data were from maternal telephone interviews, which included a food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were generated from logistic regression models that included nutritional factors as continuous variables and were adjusted for energy intake only or energy intake plus covariates (maternal race‐ethnicity, education, age, prepregnancy body mass index, vitamin/mineral supplement intake, conception during summer). Models included a quadratic term for the nutrient if p < 0.10. ORs reflect odds of having biliary atresia for nutrient values at the 75th compared to 25th percentile values of each nutrient, based on distributions among controls.ResultsORs for which the 95% CI excluded 1.00 were energy‐adjusted ORs for calcium (0.63), protein (0.65), riboflavin (0.71), and diet quality index (0.69), and fully adjusted ORs for calcium (0.68) and vitamin E (0.72). ORs that were fully adjusted for covariates tended to be closer to 1.0 than ORs adjusted only for energy intake. ORs for the other studied nutrients had 95% CIs that included 1.00.ConclusionsNBDPS is the first study to include detailed information on maternal dietary intake and risk of biliary atresia. Our results suggest reduced risks associated with some nutrients, which may provide etiologic clues but should be interpreted with caution given the small number of cases and novelty of the investigation.
Einfluss der thermischen Behandlung auf die Festigkeiten von feinkörnigem ultrahochfestem Beton (UHPC/RPC)
Authors: Rhau Marcel , Schnellenbach‐Held Martina , Welsch Torsten 
Published: May 2018

AbstractDurch eine gezielte thermische Nachbehandlung können die Biegezug‐ und Druckfestigkeiten von Ultrahochleistungsbetonen (Ultra‐High Performance Concrete, UHPC) deutlich erhöht werden. In den meisten Veröffentlichungen wird eine Vorlagerzeit von 1–2 Tagen, eine Haltetemperatur von 60–90 °C sowie eine Haltezeit von 24–48 Stunden empfohlen [1, 2]. Eigene Voruntersuchungen zur thermischen Behandlung von feinkörnigem UHPC (RPC) am Institut für Massivbau der Universität Duisburg‐Essen zeigten, dass durch andere Variationen bessere Ergebnisse erzielt werden konnten. Daher wurden detailliertere Untersuchungen zur Vorlagerzeit sowie zur Haltetemperatur an zwei unterschiedlichen UHPC‐Mischungen durchgeführt. Weiterhin wurde der Einfluss eines Schutzes der Proben vor dem Austrocknen während der thermischen Behandlung erforscht. Die Ergebnisse und die Auswertung dieser Untersuchungen werden in dieser Veröffentlichung dokumentiert. Es zeigte sich, dass die Behandlungstemperatur den größten Einfluss auf die Druckfestigkeit hat. Zur Steigerung der Biegezugfestigkeit war der Schutz der Proben entscheidend. Weiterhin ist festzuhalten, dass sich für die verschiedenen Mischungszusammensetzungen unterschiedliche Regimes für die thermische Behandlung als am effizientesten herausstellten.
Lactoferricin B reverses cisplatin resistance in head and neck squamous cell carcinoma cells through targeting PD‐L1
Authors: Zhang Pei , Liu Jinzhong , Li Wenlu , Li Shanshan , Han Xinguang 
Published: May 2018

AbstractHead and neck squamous cell carcinoma (HNSCC) ranks among the top most common cancers with a poor prognosis. The mechanism of chemoresistance is still not well known. This study is to investigate the programmed death‐ligand 1 (PD‐L1) expression in HNSCC, and test the effect of lactoferricin B (LfcinB) on chemoresistance and its mechanism. We analyzed 510 HNSCC patients in TCGA database and investigated how CD274 expression was related to patient prognosis. PD‐L1 was verified from HNSCC samples at local hospital with immunohistochemistry. PD‐L1 expression in the acquired cisplatin‐resistant HNSCC cells was examined by PCR and WB in order to test PD‐L1‐induced chemoresistance. LfcinB inoculation in cisplatin‐resistant HNSCC cells and in the nude mice was introduced to test the effect of LfcinB on targeting cisplatin resistance and its mechanism. High CD274 mRNA (>125 FPKM) from TCGA database had a significantly reduced 5‐year survival rate, and a lower 5‐year survival rate in the chemotherapy and radiotherapy‐treated patients (P < .05). PD‐L1 overexpression was further supported from analysis of 40 HNSCC specimens. PD‐L1 and IL‐6 in the established cisplatin‐resistant HNSCC cells were shown significantly higher (P < .05). IL‐6 and PD‐L1 expression were partially inhibited by the anti‐IL‐6/STAT3 antibody. LfcinB displayed a direct cytotoxic effect on cisplatin‐resistant HNSCC cells and HNSCC xenografts of cisplatin‐resistant cells in the nude mice displayed significant reduction in tumor volume after LfcinB injection (P < .05). Besides, the increase of IL‐6 and PD‐L1 in cisplatin‐resistant HNSCC cells was abolished in vitro by LfcinB (P < .05). PD‐L1 expression in HNSCC cells correlates with poor prognosis and chemoresistance, and LfcinB might provide therapeutic potential in HNSCC patients through modulating IL‐6 and PD‐L1.
Evaluation of the ThroLy score for the prediction of venous thromboembolism in newly diagnosed patients treated for lymphoid malignancies in clinical practice
Authors: Rupa‐Matysek Joanna , Brzeźniakiewicz‐Janus Katarzyna , Gil Lidia , Krasiński Zbigniew , Komarnicki Mieczysław 
Published: May 2018

AbstractThe utility in clinical practice of a recently developed and validated predictive model for venous thromboembolism (VTE) events in lymphoma patients, known as the thrombosis lymphoma (ThroLy) score, is unknown. We evaluated the association of ThroLy with VTE in patients treated for diffuse large B‐cell lymphoma (DLBCL) or Hodgkin lymphoma (HL) undergoing ambulatory first‐line chemotherapy. Retrospective analyses were performed on 428 patients (median age 50), 241 were newly diagnosed DLBCL, and 187 had HL. During initial chemotherapy, 64 (15%) patients developed VTE. According to the ThroLy, 322 (75.2%) patients were considered low risk, 88 (20.6%) patients had intermediate risk and 18 (4.2%) patients high risk for VTE development. Patients with DLBCL were more often in the high‐risk ThroLy group and had more VTE events than HL. VTE occurred in; 38.9% (n = 7) high‐risk patients, 29.5% (n = 26) intermediate risk, and 9.6% (n = 31) low risk according to the ThroLy score. However, in multivariate analysis, high ThroLy (OR 5.13; 95% CI: 1.83‐14.36, P = .002), intermediate ThroLy (OR 3.96; 95% CI: 2.19‐7.17, P < .001), and aggressive lymphoma‐DLBCL (OR 1.91; 95% CI: 1.05‐3.47, P = .034) were all significantly associated with development of VTE, 48% of the VTE events occurred in the low‐risk ThroLy score group (the ROC AUC (95% CI) 0.40‐0.70 and C statistic‐0.55). In our study, the ThroLy score was not a suitably accurate model for predicting VTE events in patients at higher risk of VTE. Further research should be conducted to identify new biomarkers that will predict these events and to establish a new VTE risk assessment model.
Systematic analyses of a novel lncRNA‐associated signature as the prognostic biomarker for Hepatocellular Carcinoma
Authors: Sui Jing , Miao Yan , Han Jiali , Nan Hongmei , Shen Bo , Zhang Xiaomei , Zhang Yan , Wu Yuan , Wu Wenjuan , Liu Tong , Xu Siyi , Yang Sheng , Yin Lihong , Pu Yuepu , Liang Geyu 
Published: May 2018

AbstractAccumulating evidence implies that long noncoding RNAs (lncRNAs) play a crucial role in predicting survival for Hepatocellular carcinoma (HCC) patients. This study aims to capture the current research hotspots of HCC, based on the analysis of publications related to HCC research from 2013 to 2017, and to identify a novel lncRNA signature for HCC prognosis through the data mining in The Cancer Genome Atlas (TCGA). “Prognosis” and “biomarker” were located in the core of the HCC research hotspot. Moreover, long noncoding RNA was the top one research frontier in HCC research. The associations between survival outcome and the expression of lncRNAs were evaluated by the univariate and multivariate Cox proportional hazards regression analyses. Four lncRNAs (LINC00261, TRELM3P, GBP1P1, and CDKN2B‐AS1) were identified as significantly correlated with overall survival (OS). These four lncRNAs were gathered as a single prognostic signature. There was a significant positive correlation between HCC patients with low‐risk scores and overall survival (HR = 1.802, 95%CI [1.224‐2.652], P = .003). Further analysis suggested that the prognostic value of this four‐lncRNA signature was independent in clinical features. The enrichment analysis of prognostic lncRNA‐related gene was performed to find out the related pathways. Our study indicates that this novel lncRNA expression signature may be a useful biomarker of the prognosis for HCC patients, based on bioinformatics analysis.