bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testing cross‐lagged relationships between work‐related rumination and well‐being at work in a three‐wave longitudinal study across 1 and 2 years
Authors: Kinnunen Ulla , Feldt Taru , de Bloom Jessica 
Published: February 2019

The aim of this three‐wave longitudinal study conducted among 664 Finnish employees was to examine the cross‐lagged relationships between various work‐related ruminative thoughts (affective rumination, problem‐solving pondering, lack of detachment from work) during off‐job time and employee well‐being (exhaustion, vigour). We tested normal, reversed, and reciprocal temporal relationships across 1 and 2 years using structural equation modelling. The analyses lent most support to the reversed temporal relationships, showing first that high exhaustion predicted low problem‐solving pondering 2 years later and second, that high vigour predicted low affective rumination both 1 and 2 years later. In addition, a normal temporal relationship was supported in one model, indicating that high affective rumination predicted high exhaustion 1 year later. Thus, our study suggests that affective ruminative thoughts, in particular, play a negative role in cross‐lagged relationships. On the basis of our results, occupational health interventions intended to reduce both affective work‐related rumination and exhaustion and to increase vigour at work are desirable.Practitioner points

Affective rumination during off‐job time predicted increased job exhaustion across 1 year. Prevent affective rumination by training employees to change ways of thinking and to create action plans on setting and completing work goals.

Vigour predicted reduced affective work‐related rumination in the long term. Provide employees with sufficient job resources to increase their vigour at work.

Exhaustion predicted reduced problem‐solving pondering during off‐job time in the long term. Attention should be paid to ensuring that job demands are not so high that they increase exhaustion. Care should be taken to ensure that problem‐solving pondering replenishes energy resources.
Effects of dietary resveratrol supplementation during gestation and lactation of sows on milk composition of sows and fat metabolism of sucking piglets
Authors: Sun Shishuai , Meng Qingwei , Luo Zhang , Shi Baoming , Bi Chongpeng , Shan Anshan 
Published: February 2019

AbstractThe purpose of this article was to investigate the effects of dietary resveratrol supplementation during gestation and lactation of sows on the milk composition of sows and the fat metabolism of sucking piglets. Forty sows were allotted to two experimental treatment groups that included the following: (a) control sows (CON treatment, n = 20) fed with a corn–soybean meal control diet and (b) treatment sows (RES treatment, n = 20) fed with a control diet with addition of 300 mg/kg resveratrol. The results showed that the content of lactose in the colostrum was increased (p < 0.05) and the content of fat in 21‐day milk was increased (p < 0.05) by dietary resveratrol supplementation. In the RES treatment group, the concentrations of high‐density lipoprotein‐cholesterol (HDL‐C), low‐density lipoprotein‐cholesterol (LDL‐C), lipase activity and insulin (INS) in plasma of sucking piglets were increased (p < 0.05). In the adipose tissue, the enzyme activities of hormone‐sensitive lipase (HSL), acetyl‐CoA carboxylase (ACC) and lipoprotein lipase (LPL) increased significantly by RES treatment (p < 0.05), and the mRNA levels of acetyl coenzyme A‐alpha (ACCα), LPL, fatty acid transport protein (FATP1) and CCAAT–enhancer‐binding protein gene (C/EBPα) were higher in the RES treatment group (p < 0.05). In conclusion, resveratrol supplementation on gestational and lactating sows improved the content of lactose in the colostrum and the content of fat in milk at day 21 of lactation. In addition, resveratrol supplementation on sows increased HDL and LDL in the plasma of piglets. In piglet adipose tissue, the enzyme activity and mRNA level related to lipolysis, fatty acid uptake from circulating triacylglycerols and lipogenesis are partially improved by resveratrol supplementation on sows. These aspects affect fat metabolism in piglets.
The role of psychological factors in pediatric functional abdominal pain disorders
Authors: Newton Emily , Schosheim Alex , Patel Samit , Chitkara Denesh K. , van Tilburg Miranda A. L. 
Published: February 2019

AbstractBackgroundPediatric functional abdominal pain disorders (FAPDs) are disorders of brain‐gut dysregulation. Psychological factors are known to be related to etiology, maintenance, and exacerbation of pediatric FAPDs. With the evolving literature in the past two decades, a better understanding has emerged of precisely which psychological factors are associated with childhood FAPDs.PurposeThis narrative literature review summarizes the literature of both child and parent psychological factors in pediatric FAPD. Where anxiety and depression were major targets in the older literature, present‐day focus is increasingly on pain‐specific cognitions and coping strategies including disease threat and catastrophizing. In addition, parental reaction to a child's pain is increasingly recognized as an important moderator of a child's outcomes and has become an area for clinical intervention. Screening for these factors and integrative treatment approaches are recommended in childhood FAPD.
Basal cell ameloblastoma in a paediatric patient: a case report and review of oral basal cell tumours
Authors: Kazakydasan S. , Zamhari A.K. , Achol L.T. 
Published: February 2019

AbstractBasal cell ameloblastoma (BCA) is a rare histological variant of ameloblastoma. It is composed of densely packed nests and strands of basaloid cells with inconspicuous stellate reticulum‐like cells. To date, there are only 24 reported cases of BCA in the English language literature. Ameloblastoma in children is relatively an uncommon tumour and accounts for approximately 15% among all odontogenic tumours. We report a case of BCA in an 8‐year‐old Iban girl who underwent hemimandibulectomy and reconstruction of the mandible with costochondral graft (CCG). A 6 months review showed that healing process was uneventful. She is under regular follow‐up and monitoring since multicystic ameloblastoma tend to recur and also the growth of the CCG is extremely unpredictable.
Kinetics of Helios(+) and Helios(−) T regulatory cell subsets in the circulation of healthy pregnant women
Authors: Kopřivová Helena , Hájková Michaela , Koucký Michal , Malíčková Karin , Holáň Vladimír , Krulová Magdalena 
Published: February 2019

AbstractRegulatory T cells (Tregs) play a critical role in the maintenance of a pregnancy. While the kinetics of the number of peripheral blood Tregs has been satisfactorily described in mouse models, analysis of these cell populations in human pregnancy is complicated by high variability in the quantity of Tregs and inconsistencies in the markers used for detecting different types of Treg. In the light of this, we set out to investigate the kinetics of various types of Treg, including CD45RA, GARP and PD‐1(+) Tregs, in the peripheral blood of pregnant women in the first, second and third trimester, and at the time of delivery. Tregs, defined as a CD4(+)CD25(++)CD127(dim)Foxp3(+) population of leucocytes, were detected using flow cytometry. Natural thymus‐derived Tregs and induced Tregs in the peripheral blood were distinguished by the expression or absence of a Helios marker, respectively. Our results showed that during normal pregnancy the sizes of various Treg subpopulations varied across women and also in an individual woman did not remain constant but varied significantly, most notable being the decrease observed at the time of delivery. Helios(−) cells were significantly less frequent in the peripheral blood of healthy pregnant women than Helios(+) cells, and the majority of Tregs were Helios(+)PD‐1(+) Tregs.
Deliberation and Complexity of Thinking. Using the Integrative Complexity Scale to Assess the Deliberative Quality of Minipublics
Authors: Jennstål Julia 
Published: February 2019

AbstractThe quality of deliberative conversations are dependent on citizens compliance with deliberative norms yet there is a lack of methods to assess norm compliance in discussions. Here, the psychological construct of complexity of thinking is claimed to conceptually correspond to the deliberative conversational ideal and adopted as a measurement of deliberative norm compliance. The hypothesis that citizens' complexity of thinking increases as a result of participation in deliberative conversations was tested in a minipublic case study in Sweden. Participants' complexity of thinking was assessed before and after deliberation by responding to an open‐ended question about the topic of debate. Manual coding was used to rate participants integrative complexity. The result confirms the hypothesis, which serves as an indicator of deliberative quality. The study also demonstrates that women get higher increases in complexity, as do highly agreeable individuals and those who hold more liberal views. The findings demonstrate the potential usefulness of integrative complexity as a measurement of deliberative quality.
International haemovigilance: what have we learned and what do we need to do next?
Authors: Wood E. M. , Ang A. L. , Bisht A. , Bolton‐Maggs P. H. , Bokhorst A. G. , Flesland O. , Land K. , Wiersum‐Osselton J. C. , Schipperus M. R. , Tiberghien P. , Whitaker B. I. 
Published: February 2019

SUMMARYThe International Haemovigilance Network (IHN) defines haemovigilance as ‘a set of surveillance procedures covering the whole transfusion chain (from the collection of blood and its components to the follow‐up of recipients), intended to collect and assess information on unexpected or undesirable effects resulting from the therapeutic use of labile blood products, and to prevent their occurrence or recurrence’. IHN, the International Society of Blood Transfusion and World Health Organization work together to support both developing and established haemovigilance systems.Haemovigilance systems provide valuable data on a range of adverse events related to blood donation and clinical transfusion, from donor syncopal events to transfusion‐transmitted infections, immunological complications and the impact of human errors. Harmonised definitions for most adverse reactions have been developed and validated internationally. Definitions of pulmonary complications are again under review.Haemovigilance data have resulted in changes in policy, products and practice, and can complement and inform clinical audit and research, leading to improved blood donor safety, optimised product use and better clinical outcomes after transfusion.However, more work is needed. Not all countries have haemovigilance systems in place. More robust data and careful analysis are required to improve the understanding of the causes, occurrence and clinical outcomes of these events. Wider dissemination of results will facilitate health policy development internationally, and implementation of haemovigilance recommendations will support further important progress in blood safety.
ABA inhibits myristoylation and induces shuttling of the RGLG1 E3 ligase to promote nuclear degradation of PP2CA
Authors: Belda‐Palazon Borja , Julian Jose , Coego Alberto , Wu Qian , Zhang Xu , Batistic Oliver , Alquraishi Saleh A. , Kudla Joerg , An Chengcai , Rodriguez Pedro L. 
Published: February 2019

SummaryHormone‐ and stress‐induced shuttling of signaling or regulatory proteins is an important cellular mechanism to modulate hormone signaling and cope with abiotic stress. Hormone‐induced ubiquitination plays a crucial role to determine the half‐life of key negative regulators of hormone signaling. For ABA signaling, the degradation of clade‐A PP2Cs, such as PP2CA or ABI1, is a complementary mechanism to PYR/PYL/RCAR‐mediated inhibition of PP2C activity. ABA promotes the degradation of PP2CA through the RGLG1 E3 ligase, although it is not known how ABA enhances the interaction of RGLG1 with PP2CA given that they are predominantly found in the plasma membrane and the nucleus, respectively. We demonstrate that ABA modifies the subcellular localization of RGLG1 and promotes nuclear interaction with PP2CA. We found RGLG1 is myristoylated in vivo, which facilitates its attachment to the plasma membrane. ABA inhibits the myristoylation of RGLG1 through the downregulation of N‐myristoyltransferase 1 (NMT1) and promotes nuclear translocation of RGLG1 in a cycloheximide‐insensitive manner. Enhanced nuclear recruitment of the E3 ligase was also promoted by increasing PP2CA protein levels and the formation of RGLG1–receptor–phosphatase complexes. We show that RGLG1Gly2Ala mutated at the N‐terminal myristoylation site shows constitutive nuclear localization and causes an enhanced response to ABA and salt or osmotic stress. RGLG1/5 can interact with certain monomeric ABA receptors, which facilitates the formation of nuclear complexes such as RGLG1–PP2CA–PYL8. In summary, we provide evidence that an E3 ligase can dynamically relocalize in response to both ABA and increased levels of its target, which reveals a mechanism to explain how ABA enhances RGLG1–PP2CA interaction and hence PP2CA degradation.
Factors affecting lymphocyte collection efficiency for the manufacture of chimeric antigen receptor T cells in adults with B‐cell malignancies
Authors: Tuazon Sherilyn A. , Li Ang , Gooley Theodore , Eunson Thomas W. , Maloney David G. , Turtle Cameron J. , Linenberger Michael L. , Connelly‐Smith Laura S. 
Published: February 2019

BACKGROUNDThe clinical and procedural parameters that affect the optimal collection of lymphocytes for the production of chimeric antigen receptor (CAR) T cells remain undefined but are increasingly important, as commercial products are now available. We evaluated determinants of low lymphocyte collection efficiency (CE) and the rate of successful CAR T‐cell manufacture in middle‐aged and older adults with advanced B‐cell malignancies.STUDY DESIGNS AND METHODSMononuclear cell collections using two apheresis platforms (COBE Spectra and Spectra Optia, Terumo BCT) from patients participating in a CD19‐directed CAR T‐cell therapy trial were reviewed. Patient‐ and disease‐specific factors, peripheral blood counts, apheresis parameters, and product cell counts were analyzed to determine effects on lymphocyte CE.RESULTSNinety‐two apheresis events from patients with acute lymphocytic leukemia (ALL) (n = 28), chronic lymphocytic leukemia (n = 18), and non‐Hodgkin lymphoma (n = 46) were available for analysis. Forty‐one collections (45%) had a lymphocyte CE of <40%. On multivariable analysis, age (every 10‐year increase, odds ratio [OR] = 1.51; p = 0.034), disease type (chronic lymphocytic leukemia vs. ALL, OR = 0.24; p = 0.052; non‐Hodgkin lymphoma vs. ALL, OR = 0.20; p = 0.009) and precollection platelets (every 10 × 103/μL increase, OR = 1.07; p = 0.005) were appreciably associated with a lymphocyte CE of <40%. No major apheresis complications occurred.CONCLUSIONSLymphocyte collection at our center was well tolerated and 100% successful in manufacturing CD19‐directed CAR T cells from adult patients with B‐cell malignancies despite low CE in some patients. A diagnosis of ALL, advancing age, and higher preapheresis platelet counts were observed to be associated with low CE.
Nonabelian Hodge theory for klt spaces and descent theorems for vector bundles
Authors: Greb Daniel , Kebekus Stefan , Peternell Thomas , Taji Behrouz 
Published: February 2019

We generalise Simpson’s nonabelian Hodge correspondence to the context of projective varieties with Kawamata log terminal (klt) singularities. The proof relies on a descent theorem for numerically flat vector bundles along birational morphisms. In its simplest form, this theorem asserts that given any klt variety$X$and any resolution of singularities, any vector bundle on the resolution that appears to come from$X$numerically, does indeed come from $X$. Furthermore, and of independent interest, a new restriction theorem for semistable Higgs sheaves defined on the smooth locus of a normal, projective variety is established.
Reliability-Based Design Optimization of Surface-to-Surface Contact for Cutting Tool Interface Designs
Authors: Camuz Soner , Bengtsson Magnus , Söderberg Rikard , Wärmefjord Kristina 
Published: February 2019

Abstract
In recent years, cutting tool manufacturers are moving toward improving the robustness of the positioning of an insert in the tool body interface. Increasing the robustness of the interface involves designs with both chamfered and serrated surfaces. These designs have a tendency to overdetermine the positioning and cause instabilities in the interface. Cutting forces generated from the machining process will also plastically deform the interface, consequently, altering the positioning of the insert. Current methodologies within positioning and variation simulation use point-based contacts and assume linear material behavior. In this paper, a first-order reliability-based design optimization framework that allows robust positioning of surface-to-surface-based contacts is presented. Results show that the contact variation over the interface can be limited to predefined contact zones, consequently allowing successful positioning of inserts in early design phases of cutting tool designs.
Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action
Authors: Dalbram Emilie , Basse Astrid L. , Zierath Juleen R. , Treebak Jonas T. 
Published: February 2019

Metabolic dysfunction and Type 2 diabetes are associated with perturbed circadian rhythms. However, exercise appears to ameliorate circadian disturbances, as it can phase-shift or reset the internal clock system. Evidence is emerging that exercise at a distinct time of day can correct misalignments of the circadian clock and influence energy metabolism. This suggests that timing of exercise training can be important for the prevention and management of metabolic dysfunction. In this study, obese, high-fat diet-fed mice were subjected to voluntary wheel running (VWR) at two different periods of the day to determine the effects of time-of-day-restricted VWR on basal and insulin-stimulated glucose disposal. VWR in the late dark phase reduced body weight gain compared with VWR in the beginning of the dark phase. Conversely, time-of-day-restricted VWR did not influence insulin action and glucose disposal, since skeletal muscle and adipose tissue glucose uptake and insulin signaling remained unaffected. Protein abundance of the core clock proteins, brain-muscle arnt-like 1 (BMAL1), and circadian locomotor output control kaput (CLOCK), were increased in skeletal muscle after VWR, independent of whether mice had access to running wheels in the early or late dark phase. Collectively, we provide evidence that VWR in the late dark phase ameliorates diet-induced obesity without altering insulin action or glucose homeostasis. NEW & NOTEWORTHY Exercise appears to ameliorate circadian disturbances as it can entrain the internal clock system. We provide evidence that voluntary wheel running increases core clock protein abundance and influences diet-induced obesity in mice in a time-of-day-dependent manner. However, the effect of time-of-day-restricted voluntary wheel running on body weight gain is not associated with enhanced basal- and insulin-stimulated glucose disposal, suggesting that time-of-day-restricted voluntary wheel running affects energy homeostasis rather than glucose homeostasis.
Reduced corticospinal responses in older compared with younger adults during submaximal isometric, shortening, and lengthening contractions
Authors: Škarabot Jakob , Ansdell Paul , Brownstein Callum G. , Hicks Kirsty M. , Howatson Glyn , Goodall Stuart , Durbaba Rade 
Published: February 2019

The aim of this study was to assess differences in motor performance, as well as corticospinal and spinal responses to transcranial magnetic and percutaneous nerve stimulation, respectively, during submaximal isometric, shortening, and lengthening contractions between younger and older adults. Fifteen younger [26 yr (SD 4); 7 women, 8 men] and 14 older [64 yr (SD 3); 5 women, 9 men] adults performed isometric and shortening and lengthening dorsiflexion on an isokinetic dynamometer (5°/s) at 25% and 50% of contraction type-specific maximums. Motor evoked potentials (MEPs) and H reflexes were recorded at anatomical zero. Maximal dorsiflexor torque was greater during lengthening compared with shortening and isometric contractions ( P < 0.001) but was not age dependent ( P = 0.158). However, torque variability was greater in older compared with young adults ( P < 0.001). Background electromyographic (EMG) activity was greater in older compared with younger adults ( P < 0.005) and was contraction type dependent ( P < 0.001). As evoked responses are influenced by both the maximal level of excitation and background EMG activity, the responses were additionally normalized {[MEP/maximum M wave (Mmax)]/root-mean-square EMG activity (RMS) and [H reflex (H)/Mmax]/RMS}. (MEP/Mmax)/RMS and (H/Mmax)/RMS were similar across contraction types but were greater in young compared with older adults ( P < 0.001). Peripheral motor conduction times were prolonged in older adults ( P = 0.003), whereas peripheral sensory conduction times and central motor conduction times were not age dependent ( P ≥ 0.356). These data suggest that age-related changes throughout the central nervous system serve to accommodate contraction type-specific motor control. Moreover, a reduction in corticospinal responses and increased torque variability seem to occur without a significant reduction in maximal torque-producing capacity during older age. NEW & NOTEWORTHY This is the first study to have explored corticospinal and spinal responses with aging during submaximal contractions of different types (isometric, shortening, and lengthening) in lower limb musculature. It is demonstrated that despite preserved maximal torque production capacity corticospinal responses are reduced in older compared with younger adults across contraction types along with increased torque variability during dynamic contractions. This suggests that the age-related corticospinal changes serve to accommodate contraction type-specific motor control.