bluuebunny/crossref_metadata_2025_split huggingface dataset:
HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer
Authors: Johng Dorhyun , Torga Gonzalo , Ewing Charles M. , Jin Kideok , Norris John D. , McDonnell Donald P. , Isaacs William B. 
Published: December 2018

BackgroundThe recurrent p.Gly84Glu germline mutation (G84E) in HOXB13 is consistently associated with prostate cancer (PCa), although the mechanisms underlying such linkage remain elusive. The majority of the PCa‐associated HOXB13 mutations identified are localized to two conserved domains in HOXB13 that have been shown to mediate the interaction with MEIS cofactors belonging to the TALE family of homeodomain transcription factors. In this study, we sought to interrogate the biochemical and functional interactions between HOXB13 and MEIS in prostatic cells with a goal of defining how the HOXB13‐MEIS complex impacts PCa pathobiology and define the extent to which the oncogenic activity of G84E is related to its effect on HOXB13‐MEIS interaction/function.MethodsHOXB13 and MEIS paralog expression in prostate epithelial cells and PCa cell lines was characterized by qPCR and immunoblot analyses. HOXB13 and MEIS1 co‐expression in human prostate tissue was confirmed by IHC, followed by co‐IP mapping of HOXB13‐MEIS1 interactions. Proliferation of the PCa cell line LAPC4 following shRNA‐mediated knockdown of each gene or both genes was assessed using DNA‐ and metabolic‐based assays. Transcriptional targets of HOXB13 and MEIS1 were identified by gene expression profiling and qPCR. Finally, protein stability of HOXB13 in the context of MEIS1 was determined using pulse‐chase assays.ResultsHOXB13 and MEIS1 are co‐expressed and interact in prostate cells. Both of the putative MEIS interacting domains (MID) within HOXB13 were shown to be capable of mediating the interaction between HOXB13 and MEIS1 independently and such interactions were not influenced by the G84E mutation. The inhibitory effect of either HOXB13 or MEIS1 knockdown on cellular proliferation was augmented by knockdown of both genes, and MEIS1 knockdown abolished HOXB13‐driven regulation of BCHE and TNFSF10 mRNA expression. Notably, we demonstrated that MEIS1 stabilized the HOXB13 protein in LAPC4 cells.ConclusionsOur study provides evidence for functional HOXB13‐MEIS1 interactions in PCa. MEIS1 may contribute to the cancer‐promoting actions of HOXB13 in cellular proliferation and gene regulation by prolonging HOXB13 half‐life. Our data demonstrates that G84E is not a loss‐of‐function mutation that interferes with HOXB13 stability or ability to interact with MEIS1.
Synthesis of a Novel Polycarboxylate Superplasticizer with Hyperbranched Structure
Authors: Ao Lei , Zhao Wei , Lei Qiang , Wang Dingkai , Guan Yinshuang , Liu Kaishuai , Guo Tiantian , Fan Xing , Wei Xianyong 
Published: December 2018

AbstractIt is well established that the performance of super‐plasticizer (PCE) is mostly determined by its molecular structure. This research tends to combine PCE with hyperbranched polymer and design PCE molecule structure, aiming to enhance the water‐reducing performance of PCE. Here, a novel PCE with hyperbranched molecular structure (HBPCE) was synthesized through two steps. With diallylamine, methyl propenoate and trihydroxymethylpropane as raw material, firstly, a hyperbranched monomer B was successfully synthesized. Then through free radical polymerization of methylallylpoly oxygenethene ether 2400 (HPEG 2400), propenoic acid (AA) and the monomer B in aqueous solution, the final product HBPCE was obtained. 1H nuclear magnetic resonance (1H NMR) and infrared spectroscopy (IR) measurements were used for structural characterization, and gel chromatography was used to measure the molecular weight distribution of HBPCE. In addition, performances of HBPCE in cement paste were investigated. It is concluded that HBPCE has a good dispersing effect on cement paste and the water reduction ratio is up to 38.6%.
Gold‐Loaded Nanoporous Iron Oxide Cubes Derived from Prussian Blue as Carbon Monoxide Oxidation Catalyst at Room Temperature
Authors: Tanaka Shunsuke , Zakaria Mohamed Barakat , Kaneti Yusuf Valentino , Jikihara Yohei , Nakayama Tsuruo , Zaman Mukter , Bando Yoshio , Hossain Md. Shahriar A. , Golberg Dmitri , Yamauchi Yusuke 
Published: December 2018

AbstractThis work reports the preparation of carbon monoxide (CO) oxidation catalysts based on gold nanoparticles supported on nanoporous iron oxide cubes. By heat‐treating Prussian blue (PB) cubes at various temperatures between 250–450 °C in air, nanoporous iron oxide cubes with surface areas up to 100 m2 g−1 are obtained. Owing to the relatively large surface area and nanoporous structure, the as‐synthesized iron oxide cubes can be loaded with up to 11 wt% of Au nanoparticles without significant aggregation. When employed for CO oxidation, the Au‐loaded nanoporous iron oxide cubes exhibit a high CO conversion rate of over 95% at room temperature under 0.1 L⋅min−1 of CO gas flow, with specific activity of up to 1.79 molCO⋅gAu−1⋅h−1. The high catalytic performance of the Au‐loaded nanoporous iron oxide cubes for CO oxidation is contributed by various factors, including: (i) the high surface area of the iron oxide cubes which leads to the availability of more sites for the adsorption of oxygen molecules to react with carbon monoxide to generate more carbon dioxide (CO2); (ii) the presence of nanopores which enhances the diffusivity of the reactant molecules during the catalytic reaction and improves dispersion of the deposited gold nanoparticles while also preventing their aggregation at the same time and (iii) the small size of the deposited gold nanoparticles (2‐5 nm) which falls within the ideal size of gold nanoparticles for achieving high CO conversion.
UIO‐66‐NH2‐Derived Mesoporous Carbon Catalyst Co‐Doped with Fe/N/S as Highly Efficient Cathode Catalyst for PEMFCs
Authors: Zheng Long , Dong Yuanyuan , Chi Bin , Cui Zhiming , Deng Yijie , Shi Xiudong , Du Li , Liao Shijun 
Published: December 2018

AbstractEfficient, low‐cost catalysts are desirable for the sluggish oxygen reduction reaction (ORR). Herein, UIO‐66‐NH2‐derived multi‐element (Fe, S, N) co‐doped porous carbon catalyst is reported, Fe/N/S‐PC, with an octahedral morphology, a well‐defined mesoporous structure, and highly dispersed doping elements, synthesized by a double‐solvent diffusion‐pyrolysis method (DSDPM). The morphology of the UIO‐66‐NH2 precursor is perfectly inherited by the derived carbon material, resulting in a high surface area, a well‐defined mesoporous structure, and atomic‐level dispersion of the doping elements. Fe/N/S‐PC demonstrates outstanding catalytic activity and durability for the ORR in both alkaline and acidic solutions. In 0.1 m KOH, its half‐potential reaches 0.87 V (vs reversible hydrogen electrode (RHE)), 30 mV more positive than that of a 20 wt% Pt/C catalyst. In 0.1 m HClO4, it reaches 0.785 V (vs RHE), only 65 mV less than that of Pt/C. The catalyst also exhibits excellent performance in acidic hydrogen/oxygen proton exchange membrane fuel cells. A membrane electrode assembly (MEA) with the catalyst as the cathode reaches 700 mA·cm‐2 at 0.6 V and a maximum power density of 553 mW·cm‐2, ranking it among the best MEAs with a nonprecious metal catalyst as the cathode.
Optimal Strategies for Utility from Terminal Wealth with General Bid and Ask Prices
Authors: Rogala Tomasz , Stettner Lukasz 
Published: December 2018

AbstractIn the paper we study utility from terminal wealth maximization with general bid and ask prices studying first one asset case and generalizing then results to the multi asset case. We show that under certain assumptions (continuous conditional distribution of the assets) and strict concavity of the utility function the problem can be reduced to study a static problem and then by an induction to consider multi period case. We obtain formulae for buying, selling and no transaction zones both in one and two asset cases. We also show the existence and the form of shadow prices.
Taeniectomy Versus Transverse Coloplasty as Neorectum After Low Rectal Resection
Authors: Farag Ahmed , Mashhour Abdrabou N. , Elbarmelgi Mohamed Yehia 
Published: December 2018

AbstractPurposeRestorative surgery for rectal cancer is usually criticized by its functional outcomes. The aim of this study is to assess the efficacy “taeniectomy” pouch in comparison with transverse coloplasty pouch.Study designThis was a prospective controlled study. Most patients who were candidate for low rectal resection presented to colorectal unit at Cairo university hospitals during the period from February 2013 to August 2016 were divided into two groups. The total number of patients enrolled in the study was 180 patients. Ninety patients were subjected to low rectal resection with the transverse coloplasty pouch, and 90 patients were subjected to low rectal resection with the newly described taeniectomy pouch. Safety and feasibility of both techniques were assessed about leakage, operative time, difficulty in evacuation, incontinence, number of daily motions and postoperative urgency. Both groups were assessed clinically, by means of defecography and anorectal manometry.ResultsThere was no significant statistical difference between taeniectomy and transverse coloplasty regarding postoperative leakage (P value = 0.988), postoperative mortality (P value = 0.99) and functional outcomes including number of motions per day (P value was 0.403 at 3 months and 0.361 at 12 months), urgency (P value was 0.688), continence grade (P value was 0.320 and 0.683 in 3 and 12 months, respectively) and manometric findings. However, taeniectomy is statistically significant better in terms of operative time (P value = 0.001).ConclusionsTaeniectomy is a newly described, technically easier technique for pouch formation after low rectal resection that can be used as a safe and effective alternative for the widely used transverse coloplasty.
Overview of ytterbium based transparent ceramics for diode pumped high energy solid-state lasers
Authors: David Samuel Paul , Jambunathan Venkatesan , Lucianetti Antonio , Mocek Tomas 
Published: December 2018

Development of high energy laser sources with nanosecond pulses at several hertz values for repetition rate has been very attractive in recent years due to their great potential for practical applications. With the recent advancement in fabricating large size laser quality transparent ceramics, diode pumped solid-state laser generating pulse energy of 100 J at 10 Hz has been recently realized at HiLASE center using Yb:YAG ceramic with Cr:YAG cladding. This review discusses Yb based high energy lasers, specific laser geometries for efficient thermal management and the role of transparent ceramics in such diode pumped high-energy-class solid-state lasers around the world.
Reformulating the common law rules on the recognition and enforcement of foreign judgments
Authors: Arzandeh Ardavan 
Published: December 2018

AbstractThis paper revisits the English common law rules on the recognition and enforcement of foreign judgmentsin personam. It seeks to demonstrate that, mainly due to the narrow conception of the foreign courts’ ‘international jurisdictional competence’, the operation of this aspect of the English conflict-of-laws rules gives rise to problematic outcomes. Subsequently, the paper proceeds to identify and evaluate three of the main doctrinal models which have been proposed in response to these shortcomings. It is contended that, despite their virtues, ultimately, none of these models provides the desirable basis for recasting the law. The paper's main contribution is, therefore, to advance an alternative approach for the reformulation of the recognition and enforcement regime at common law. In this regard, it is argued that the foreign courts’ international jurisdictional competence should be defined more broadly as to include the jurisdictional ‘gateways’, presently codified within CPR Practice Direction 6B para 3.1.
Disrupting doctrine? Revisiting the doctrinal impact of relational contract theory
Authors: Tan Zhong Xing 
Published: December 2018

AbstractWhile the concept of the ‘relational contract’ has been invoked in the courts with greater visibility and regularity in recent years, the doctrinal import of relational contract theory remains for the most part unclear to contract and commercial lawyers. This paper offers a broad framework for understanding the different ways through which relational theory might have an impact on contract doctrine going forward, and evaluates the promises and perils of doing so.
Neuropeptide Y and religious commitment in healthy young women
Authors: Tønnesen Mathilde T. , Miani Alessandro , Pedersen Anders Sune , Mitkidis Panagiotis , Zak Paul J. , Winterdahl Michael 
Published: December 2018

AbstractObjectiveThe present study explores the relationship between neuroactive hormones and religious commitment. We hypothesised that religious commitment is mediated by neuropeptide Y and oxytocin. These neurohormones have a well-established role in general well-being, anxiety regulation, stress-resilience, social affiliation and spirituality.MethodsSixty healthy women (median age 21) participated in the study and completed the Religious Commitment Inventory and other psychometric surveys. Blood was sampled from each participant and serum levels of neuropeptide Y were measured using radioimmunoassay. Oxytocin, stress and sex hormones were measured using enzyme-linked immunosorbent assay. Correlations were tested using non-parametric statistical methods.ResultsWe found a positive correlation between serum neuropeptide Y levels and religious commitment, but not between oxytocin and religious commitment.ConclusionsThe present study provides preliminary evidence that neuropeptide Y is a biological correlate of religious commitment.
Postglacial alluvial fan dynamics in the Cordillera Oriental, Peru, and palaeoclimatic implications
Authors: Ratnayaka Kevin , Hetzel Ralf , Hornung Jens , Hampel Andrea , Hinderer Matthias , Frechen Manfred 
Published: December 2018

AbstractAlluvial fans record climate-driven erosion and sediment-transport processes and allow reconstructing past environmental conditions. Here we investigate the sedimentation history of two alluvial fans located in formerly glaciated valleys of the Cordillera Oriental, Peru.10Be exposure ages from the fan surfaces and radiocarbon ages from the fan interiors constrain the final stages of fan formation. The10Be and14C ages cluster mainly between 13.3–9.3 ka and 11,500–9700 cal yr BP, respectively. Our age data set indicates that—after deglaciation—large amounts of fan sediment were deposited until ∼10 ka, when sedimentation rates declined rather abruptly. This pattern is supported by10Be erosion rates for the fan catchments, because under the assumption of constant erosion the time needed to erode the material stored in the fans significantly exceeds their age. Correlating our ages with regional climate records indicates that precipitation exerts the primary control on fan sedimentation. Two periods with elevated lake levels and increased precipitation between 18 and 14.5 ka and from 13 to 11.5 ka resulted in rapid deposition of large fan lobes. Subsequently, lower precipitation rates decreased erosion in the catchments and sediment delivery to the fans, which have remained largely inactive since ∼9.5 ka.
Preaching to Seneca: Christ as StoicSapiensinDivinae Institutiones IV
Authors: Hansen Benjamin 
Published: December 2018

AbstractLactantius’sDivine Institutesis a conversation with many partners. His affinity for Stoic thought in general, and Seneca in particular, is especially pronounced. Throughout theInstituteswe find a delicate back-and-forth between Lactantius’s claim of a novel philosophy centered on the Christian Gospel and his attraction to—and dependence on—the pagan philosophy he hoped to supplant. This interplay is distinctly relevant to Lactantius’s portrayal of the figure of Jesus inInstitutes IV. In this paper, I argue that Lactantius shapes his story of the nature and work of Jesus in part to give an answer to a primary Stoic question: where is thesapiens? Indeed, the figure of thesapiens, the “Stoic sage,” had presented something of a problem for the Stoa: Stoic cosmology demanded he exist while Stoic history had failed to find him. By Seneca’s time, a resigned acceptance of the absence of such figures of incarnate wisdom was commonplace; the figure of thesapienshad begun to fade away into the realm of theory, separated from imperfect human practice. In redressing this concern, Lactantius portrays his Christ: the true sage andexemplum, wisdom and virtue incarnate. In short, to Seneca’s resignation, Lactantius offers a rebuke and a corrective by a clever re-shaping of both Christian and Stoic expectation.
Relationship between the fatty acid profile of hair and energy availability of lactating primiparous cows
Authors: Möller Ramona , Dannenberger Dirk , Nürnberg Gerd , Strucken Eva-Maria , Brockmann Gudrun A. 
Published: December 2018

AbstractWe hypothesised that a relationship would exist between hair fatty acids, especially C12:0, C14:0 and C16:0, and parameters of energy metabolism such as energy intake, energy mobilisation, and energy requirement for maintenance and milk performance. For this study, 11 primiparous German Holstein cows were available from which hair samples at weeks 6 and 8 of lactation were analysed. The average body weight of these animals was 558 ± 27 kg at calving and milk yield at 100-days in milk was 3,537 ± 529 kg. Feed intake and milk yield were measured daily. Body weight and back fat thickness were measured at calving and in weeks 2, 4, and 8 of lactation. Energy balance and energy utilisation were calculated until week 6 of lactation. Spearman's correlation coefficients were found to be significantly positive for the relationship between the percentage of C12:0 and C14:0 fatty acids in the hair in lactation week 8 and energy intake in weeks 5 and 6 (0.62 < r < 0.65, P < 0.05). If the animals are grouped according to their energy utilisation between weeks 1 and 6 into two groups higher (n = 6) or lower (n = 5) than the median, animals of the high energy utilising group had a higher energy intake. These animals had also higher percentages of the C12:0 fatty acid in their hair fat (week 6: 4.9% vs. 3.1%, P < 0.05; week 8: 4.3% vs. 2.9%, P = 0.05). Our hypothesis is supported, and this study justifies further investigation of the content of medium-chain fatty acids in hair samples as biomarkers for the metabolic status of a cow during early lactation.
Utilization of waterholes by globally threatened species in deciduous dipterocarp forest of the Eastern Plains Landscape of Cambodia
Authors: Pin Chanratana , Ngoprasert Dusit , Gray Thomas N.E. , Savini Tommaso , Crouthers Rachel , Gale George A. 
Published: December 2018

AbstractDeciduous dipterocarp forests throughout Asia provide crucial habitat for several globally threatened species. During the dry season water availability in these forests is primarily limited to perennial rivers and waterholes. Such water sources form an essential part of these dry forests and are used by multiple species, including large mammals and birds, but little is known regarding how waterhole characteristics affect wildlife use. We investigated waterhole utilization by six globally threatened dry forest specialists: banteng Bos javanicus, Eld's deer Rucervus eldii, giant ibis Thaumatibis gigantea, green peafowl Pavo muticus, lesser adjutant Leptoptilos javanicus and Asian woolly-necked stork Ciconia episcopus. We camera-trapped 54 waterholes in Srepok Wildlife Sanctuary, eastern Cambodia, during the dry season of December 2015–June 2016. We measured nine waterhole and landscape characteristics, including indicators of human disturbance. Waterhole depth (measured every 2 weeks) and the area of water at the start of the dry season were the main environmental factors influencing waterhole use. Additionally, waterholes further from villages were more frequently used than those nearer. Our study reaffirmed the importance of waterholes in supporting globally threatened species, especially large grazers, which are critical for maintaining these dry forest ecosystems. The results also suggested that artificially enlarging and deepening selected waterholes, particularly those further from human disturbance, could enhance available habitat for a range of species, including grazers. However, this would need to be conducted in coordination with patrolling activities to ensure waterholes are not targets for illegal hunting, which is a problem throughout South-east Asian protected areas.
Long live the worms: methods for maintaining and assessing the viability of intestinal stages of Parascaris spp. in vitro
Authors: Scare J. A. , Steuer A. E. , Shaffer C. L. , Slusarewicz P. , Mousley A. , Nielsen M. K. 
Published: December 2018

AbstractIn vitro maintenance of helminth parasites enables a variety of molecular, pharmaceutical and immunological analyses. Currently, the nutritional and environmental in vitro requirements of the equine ascarid parasite, Parascaris spp., have not been determined. Additionally, an objective method for assessing viability of Parascaris spp. intestinal stages does not exist. The purpose of this study was to ascertain the in vitro requirements of intestinal stages of Parascaris spp., and to develop a viability assessment method. A total of 1045 worms were maintained in a total of 212 cultures. Worms obtained from naturally infected foals at necropsy were immediately placed in culture flasks containing 200 mL of culture media. A variety of media types, nutrient supplementation and environmental conditions were examined. A motility-based scoring system was used to assess worm viability. Worms maintained in Roswell Park Memorial Institute-1640 had significantly better viability than any other media (P < 0.0001) and all media types supplemented with any of the nutrients examined (P < 0.0001). The use of a platform rocker also significantly improved viability (P = 0.0305). This is the first study to examine the requirements for maintaining Parascaris spp. intestinal stages in vitro and to evaluate their viability based on movement using an objective scoring system.
Where are the breaks in translation from theory to clinical practice (and back) in addressing depression? An empirical graph-theoretic approach
Authors: Siegle Greg J. , Cramer Angélique O.J. , van Eck Nees Jan , Spinhoven Philip , Hollon Steven D. , Ormel Johan , Strege Marlene , Bockting Claudi L. H. 
Published: December 2018

AbstractBackgroundResearch in depression has progressed rapidly over the past four decades. Yet depression rates are not subsiding and treatment success is not improving. We examine the extent to which the gap between science and practice is associated with the level of integration in how depression is considered in research and stakeholder-relevant documents.MethodsWe used a network-science perspective to analyze similar uses of depression relevant terms in the Google News corpus (approximately 1 billion words) and the Web of Science database (120 000 documents).ResultsThese analyses yielded consistent pictures of insular modules associated with: (1) patient/providers, (2) academics, and (3) industry. Within academia insular modules associated with psychology, general medical, and psychiatry/neuroscience/biology were also detected.ConclusionsThese analyses suggest that the domain of depression is fragmented, and that advancements of relevance to one stakeholder group (academics, industry, or patients) may not translate to the others. We consider potential causes and associated responses to this fragmentation that could help to unify and advance translation from research on depression to the clinic, largely involving harmonizing employed language, bridging conceptual domains, and increasing communication across stakeholder groups.