bluuebunny/crossref_metadata_2025_split huggingface dataset:
O PERFIL DE DISPENSAÇÃO DE ANTI-HIPERTENSIVOS EM UMA FARMÁCIA DA CIDADE DE ALIANÇA-TO
Authors: Barbosa Edrys Pimentel , Souza Lucas Bezerra de , Xavier Millena Pereira , Silva Kelly Mayanny Inácio , Campos Thales Guilherme Silva , Jurema Halline Cardoso , Figueira Hávilla Clycia Oliveira Siqueira 
Published: October 2024

Introduction: Hypertension, also known as high blood pressure, is a condition that affects the blood vessels, heart, brain and eyes. If left untreated, it can even lead to kidney failure. The condition arises when blood pressure readings are repeatedly recorded above the 140 by 90 mmHg range. One form of treatment is pharmacological, with classes of drugs known as antihypertensives. Objective: To verify the dispensing profile of antihypertensive drugs in a pharmacy belonging to the Popular Pharmacy Program in the city of Aliança do Tocantins, showing the classes of drugs most commonly used to treat hypertension. Materials and methods: The data was collected from the drug dispensing records between January and April 2024 from a pharmacy in the municipality of Aliança-TO. The pharmacy in question provided spreadsheets containing detailed information on the medicines dispensed daily. This data was then compiled and analyzed. Final considerations: Through the data survey, it was concluded that Losartan was the most dispensed antihypertensive between January and May 2024 at Drogaria Brasil Popular in the city of Aliança do Tocantins-TO.
Reliability and validity of My Jump 2® app to measure the vertical jump in visually impaired five-a-side soccer athletes
Authors: Silva Julio Cesar , Silva Kalinne Fernandes , Torres Vitor Bruno , Cirilo-Sousa Maria Socorro , Medeiros Alexandre Igor Araripe , Esmeraldo Melo Jacques Eanes , Batista Gilmário Ricarte 
Published: October 2024

Background
Although My Jump 2® consistently presented excellent values of reliability and validity when compared to force platforms (FPs) and contact mats, to date no scientific investigation assessed the validity and reliability of My Jump 2® to measure jump height in visually impaired five-a-side soccer athletes. Thus, the study aimed at analyzing the validity and reliability of the My Jump 2® to measure the vertical jump of five-a-side soccer athletes.

Methods
Twelve visually impaired five-a-side soccer athletes, volunteered for this study. Each player performed five countermovement jumps (CMJs) and squat jumps (SJs) on a contact platform (CP) while they were simultaneously recorded using My Jump 2®.

Results
There was almost perfect agreement between the My Jump 2® and the contact platform measurements of CMJ (intraclass correlation coefficient = 0.99; p < 0.001) and SJ (intraclass correlation coefficient = 0.99; p < 0.001), heights for athletes during the first and second measurement days. Bland-Altman analysis showed a bias of 0.25 ± 0.5 cm; maximum SD = 1.3; minimum SD = −0.88 for CMJ, while that Bland-Altman analysis showed bias 0.18 ± 0.5 cm; maximum SD = 1.3; minimum SD = −0.96, for SJ.

Conclusion
We can conclude that the My Jump 2® is a valid and reliable method to measure CMJ and SJ in visually impaired five-a-side soccer athletes.
Forkhead box D subfamily genes in colorectal cancer: potential biomarkers and therapeutic targets
Authors: Chen Ying , Qiao Haiyan , Zhong Ruiqi , Sun Lei , Shang Bingbing 
Published: October 2024

Background
The forkhead box (FOX) family members regulate gene transcription and expression. FOX family members regulate various biological processes, such as cell proliferation and tumorigenesis. FOXD, a FOX protein subfamily, is associated with poor prognosis for various cancers. However, the potential clinical value of FOXD subfamily members in colorectal cancer (CRC) has not yet been elucidated. Therefore, in this study, we aimed to determine the role of the FOXD subfamily members in CRC development.

Methods
Using HTSeq-count data, clinical data, and single-nucleotide polymorphisms (obtained from The Cancer Genome Atlas Project), and bioinformatics analyses (using DESEQ2 software), we identified differentially expressed genes (DEGs) in CRC. Next, each DEG expression was validated in vitro using reverse transcription-quantitative polymerase chain reaction, western blotting, and immunohistochemistry (IHC).

Results
Among the FOXD subfamily members, the area under the receiver operating characteristic curve of FOXD3 was 0.949, indicating that FOXD3 has a high overall diagnostic accuracy for CRC. Gene Set Enrichment Analysis revealed that FOXD-DEGs were mainly related to pathways such as cytokine, cytokine, and extracellular matrix receptor interactions. Kaplan–Meier curves and nomograms showed that FOXD1, FOXD3, and FOXD4 were prognostically significant. In conclusion, FOXD subfamily members (especially FOXD3) could serve as diagnostic and prognostic biomarkers for CRC and an immunotherapy target in patients with CRC.
Assessing the Decadal Predictability of Land and Ocean Carbon Uptake
Authors: Séférian Roland , Berthet Sarah , Chevallier Matthieu 
Published: February 2018

AbstractThe decadal predictability of carbon fluxes has been examined over continents and oceans using a “perfect model” approach based on a 400 year preindustrial simulation and five 10‐member ensembles from the Centre National de Recherches Météorologiques‐Earth System Model version 1. From these experiments, we find that the global land uptake and ocean carbon uptake are potentially predictable by up to six years, with a median predictability horizon of four years. Predictability of global carbon uptake is prominently driven by the ocean's predictability. The difference in predictability between ocean and land carbon fluxes stems from the relative capability of ocean or land to generate low‐frequency fluctuations in carbon flux. Indeed, ocean carbon fluxes display low‐frequency variability that emerges from the year‐to‐year variability in the North Atlantic, the North Pacific, and the Southern Ocean. The Southern Ocean carbon uptake can be predicted up to six years in advance and explains most of the global carbon uptake predictability.
Changes in ENSO Activity During the Last 6,000 Years Modulated by Background Climate State
Authors: An Soon‐Il , Im Seul‐Hee , Jun Sang‐Yoon 
Published: February 2018

AbstractVarious proxy records show that El Niño–Southern Oscillation (ENSO) activity has changed from calm to active during the last 6,000 years. However, it is so far unclear whether orbital forcing has solely induced such a dramatic change. In this study, we performed a transient run for the last 6,000 years using an Earth system model of intermediate complexity affected by orbital forcing only without changes due to other climate forcing, and then its time‐varying background states were implemented into an intermediate atmosphere‐ocean coupled model for ENSO. ENSO activity simulated by the intermediate atmosphere‐ocean coupled model during the last 6,000 years resembled the observed proxy data, inferring that orbital forcing mainly leads to changes in ENSO activity during the last 6,000 years. From additional sensitivity experiments, we found that a change in sea surface temperature background conditions is primarily responsible for the observed ENSO activity over the last 6,000 years through modifying the anomalous horizontal thermal advection of the mean SST gradient.
The Influence of Water Storage in Marine Sediment on Sea‐Level Change
Authors: Ferrier Ken L. , Li Qi , Pico Tamara , Austermann Jacqueline 
Published: February 2018

AbstractSea‐level changes are of wide interest because they provide information about Earth's internal structure and the sensitivity of ice sheets to climate change. Here we illustrate the sensitivity of sea level to marine sedimentary water storage by modeling sea‐level responses to a synthetic global sediment redistribution history in which rates and patterns of erosion and deposition are similar to those at present and steady in time from the Last Interglacial to present. Our simulations show that if sediment redistribution were accounted for but sedimentary water storage were neglected, modeled sea‐level changes could be overestimated by ~2 ± 1 m of global mean sea‐level equivalent, a significant fraction of published estimates of 6–9 m of global mean sea‐level change since the Last Interglacial. These results show that sedimentary water storage may significantly contribute to changes in Earth's long‐term seawater budget over >105 year timescales and underscore the importance of accounting for it in modeling long‐term sea‐level changes.
Was the Deepwater Horizon Well Discharge Churn Flow? Implications on the Estimation of the Oil Discharge and Droplet Size Distribution
Authors: Boufadel Michel C. , Gao Feng , Zhao Lin , Özgökmen Tamay , Miller Richard , King Thomas , Robinson Brian , Lee Kenneth , Leifer Ira 
Published: February 2018

AbstractImproved understanding of the character of an uncontrolled pipeline flow is critical for the estimation of the oil discharge and droplet size distribution both essential for evaluating oil spill impact. Measured oil and gas properties at the wellhead of the Macondo255 and detailed numerical modeling suggested that the flow within the pipe could have been “churn,” whereby oil and gas tumble violently within the pipe and is different from the bubbly flow commonly assumed for that release. The churn flow would have produced 5 times the energy loss in the pipe compared to bubbly flow, and its plume would have entrained 35% more water than that of the bubbly flow. Both findings suggest that the oil discharge in Deepwater Horizon could have been overestimated, by up to 200%. The resulting oil droplet size distribution of churn flow is likely smaller than that of bubbly flow.
Mechanochemical Effect on Maturation of Carbonaceous Material: Implications for Thermal Maturity as a Proxy for Temperature in Estimation of Coseismic Slip Parameters
Authors: Kaneki S. , Ichiba T. , Hirono T. 
Published: February 2018

AbstractBecause shear stress in a fault is directly related to the frictional heat generated during slip, the thermal maturity of carbonaceous material has been used as a proxy for fault‐rock temperature. We used infrared and Raman spectroscopic analyses and friction and heating experiments to investigate enhancement of the maturation of lignite by shear damage (the mechanochemical effect) and explored the resultant implications for the use of the thermal maturity of lignite as a proxy for temperature. We showed that higher shear stress applied to lignite samples resulted in greater progression of the thermal destruction of aliphatic C─H chains and the survival of the stronger C─C bonds. Thus, we demonstrated that shear damage during earthquake slip causes mechanochemical enhancement of organochemical reactions related to the aromatization of lignite. Our results suggest that shear stress estimated from Raman spectroscopic analyses in previous studies might have been overestimated.
Methane Leakage From Hydrocarbon Wellbores into Overlying Groundwater: Numerical Investigation of the Multiphase Flow Processes Governing Migration
Authors: Rice Amy K. , McCray John E. , Singha Kamini 
Published: February 2018

AbstractMethane leakage due to compromised hydrocarbon well integrity can lead to impaired groundwater quality. Here we use a three‐dimensional, multiphase (vapor and aqueous), multicomponent (methane, water, salt), numerical model (TOUGH2 EOS7C) to investigate hydrogeological conditions that could result in groundwater contamination from natural gas wellbore leakage that migrates upward toward a freshwater aquifer. The conceptual model used for the simulations assumes methane leakage at 20–30 m below groundwater. We perform 180 simulations for a sensitivity analysis, examining (1) multiphase flow parameters related to storage, capillarity, and relative permeability, including porosity (ϕ), initial fluid‐phase saturation (SL), and van Genuchtennandα, (2) geostatistical variations in intrinsic permeability (ki), and (3) methane source‐zone pressure. Simulated meankivalues are 10−18and 10−13m2with variances of 1 and 5 m4. Simulated source‐zone pressures range from just over ambient hydrostatic pressure at the depth of leakage (100 kPa) to the maximum pressure that steel casings are commonly rated to withstand (20,340 kPa).ki, initialSL,ϕ, and van Genuchten'snandαwere the most important parameters in determining the volume of methane reaching groundwater during a given time period. Multiphase parameterization of formations underlying freshwater aquifers and overlying hydrocarbon production zones is fundamental to assessing aquifer vulnerability to methane leakage.
Effects of Unsaturated Flow on Hillslope Recession Characteristics
Authors: Luo Zhaoyang , Shen Chengji , Kong Jun , Hua Guofen , Gao Xinyu , Zhao Zhongwei , Zhao Hongjun , Li Ling 
Published: February 2018

AbstractRecession flow analysis is usually conducted to infer hydraulic parameters of hillslope aquifers. Various Boussinesq equation‐based models, both linear and nonlinear, have been used to analyze the recession curves for sloping aquifers, with a focus on the long‐time recession behavior. Based on a modified Boussinesq equation with capillarity incorporated, we demonstrate the significant effect of unsaturated flow on the recession curve, which result in three (instead of two) power law regimes with two transition points (instead of one) corresponding to the formation of a fully unsaturated zone at the adjacent area of the upslope boundary and across the whole domain, respectively. The results show that the power of the second and third recession regime is variable, depending on the slope angles, soil types, and hillslope geometries. The unsaturated flow effects also lead to the absence of drastic drop of
at the transition between the first and second regime, which was predicted by previous numerical models but has not been observed in the field or laboratory experiments. These findings have important implications for recession flow analysis in studies of hillslope aquifers.
Seasonal Variability of Magnetotactic Bacteria in a Freshwater Pond
Authors: He Kuang , Roud Sophie C. , Gilder Stuart A. , Egli Ramon , Mayr Christoph , Petersen Nikolai 
Published: February 2018

AbstractMagnetotactic bacteria (MTB) synthesize ferrimagnetic crystals that contribute to the remanent magnetization in sediments, yet knowledge of how MTB populations vary in natural environments over time remains limited. We report abundances of three MTB morphotypes from nine sites collected and measured every month over a two‐year period from a natural pond near Munich, Germany. Morphotype populations underwent coherent temporal trends among the nine sites—especially at proximal sites with similar water depths. MTB populations varied independently of bottom water oxygen concentrations or temperature over the two‐year period, except for spirilla, which flourished during the summer at some sites. Magnetic properties of the sediments did not reflect living MTB abundances, but instead varied with water depth. Deeper sites, which were also lower in organic carbon, nitrogen, and oxygen concentrations than shallower sites, had higher saturation magnetizations and were richer in single‐domain particles.
High‐Density Stretchable Electrode Grids for Chronic Neural Recording
Authors: Tybrandt Klas , Khodagholy Dion , Dielacher Bernd , Stauffer Flurin , Renz Aline F. , Buzsáki György , Vörös János 
Published: February 2018

AbstractElectrical interfacing with neural tissue is key to advancing diagnosis and therapies for neurological disorders, as well as providing detailed information about neural signals. A challenge for creating long‐term stable interfaces between electronics and neural tissue is the huge mechanical mismatch between the systems. So far, materials and fabrication processes have restricted the development of soft electrode grids able to combine high performance, long‐term stability, and high electrode density, aspects all essential for neural interfacing. Here, this challenge is addressed by developing a soft, high‐density, stretchable electrode grid based on an inert, high‐performance composite material comprising gold‐coated titanium dioxide nanowires embedded in a silicone matrix. The developed grid can resolve high spatiotemporal neural signals from the surface of the cortex in freely moving rats with stable neural recording quality and preserved electrode signal coherence during 3 months of implantation. Due to its flexible and stretchable nature, it is possible to minimize the size of the craniotomy required for placement, further reducing the level of invasiveness. The material and device technology presented herein have potential for a wide range of emerging biomedical applications.
Metal‐Free Multicomponent Reaction for Synthesis of 4,5‐Disubstituted 1,2,3‐(NH)‐Triazoles
Authors: Wu Guang‐Long , Wu Qin‐Pei 
Published: February 2018

AbstractA metal‐free domino reaction was developed for efficient synthesis of 4,5‐disubstituted 1,2,3‐(NH)‐triazoles by sequentially coupling sulfur salts with aldehydes and sodium azide. In the presence of L‐proline, olefinic sulfur salt intermediates rather than epoxides are formed in situ via the coupling of sulfur salts with aldehydes and cyclize with azide ion. This process features mild conditions, high efficiency, commercially available starting materials, and wide substrate scope.magnified image
Fabrication of AgI/MIL‐53(Fe) Composites with Enhanced Photocatalytic Activity for Rhodamine B Degradation under Visible Light Irradiation
Authors: Han Yide , Zhang Lianxia , Bai Chunpeng , Wu Junbiao , Meng Hao , Xu Yan , Liang Zhiqiang , Wang Zhuopeng , Zhang Xia 
Published: February 2018

AgI/MIL‐53(Fe) composites were fabricated through a simple solution method, and their photocatalytic activities on Rhodamine B (RhB) degradation were investigated. The results demonstrated that the introduction of AgI into the MIL‐53(Fe) was beneficial to the enhanced visible light response. Under visible light irradiation, almost 100 % RhB was bleached over AgI/MIL‐53(Fe) composites after 180 min. The promising photocatalytic performance was ascribed to three points: the existence of AgI helped to generate easily the electrons and holes in the composites; an intimate interfacial contact between MIL‐53 (Fe) and AgI offered the path for the charge carries transport; MIL‐53 (Fe) could fast transfer the excited electrons due to its inherent nature. Thus, these results were responsible for the effective inhibition of charge carrier recombination, resulting in an improved photocatalytic activity.
Nanocomposites based on titanium dioxide, modified by β‐cyclodextrin containing copolymers
Authors: Radchenko Olena , Sinelnikov Sergii , Moskalenko Oleg , Riabov Sergii 
Published: February 2018

ABSTRACTThe range of titanium dioxide (TiO2) samples, modified by β‐cyclodextrin containing copolymers was synthesized. The copolymers obtained were investigated by different methods, such as ultraviolet‐, Fourier transform infrared‐spectroscopy, thermal mass spectroscopy, thermogravimetric analysis, transmission electron microscopy, and scanning electron microscopy. The modification of TiO2 is shown to promote a significant positive impact on the process of methyl orange absorption and photodegradation on its surface. The modified TiO2‐photocatalysts prepared in such way could be promising objects for water purification from organic pollutants. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46373.
Case series of aortic arch disease treated with branched stent-grafts
Authors: Clough R. E. , Spear R. , Van Calster K. , Hertault A. , Azzaoui R. , Sobocinski J. , Fabre D. , Haulon S. 
Published: February 2018

Abstract

Background
Surgical repair of aortic arch pathology is complex and associated with significant morbidity and mortality. Alternative approaches have been developed to reduce these risks, including the use of thoracic stent-grafts with fenestrations or in combination with bypass procedures to maintain supra-aortic trunk blood flow. Branched stent-grafts are a novel approach to treat aortic arch pathology.

Methods
Consecutive patients with aortic arch disease presenting to a single university hospital vascular centre were considered for branched stent-graft repair (October 2010 to January 2017). Patients were assessed in a multidisciplinary setting including a cardiologist, cardiac surgeon and vascular surgeon. All patients were considered prohibitively high risk for standard open surgical repair. The study used reporting standards for endovascular aortic repair and PROCESS (Preferred Reporting of Case Series in Surgery) guidelines.

Results
Some 30 patients (25 men) underwent attempted branch stent-graft repair. Mean age was 68 (range 37–84) years. Eighteen patients had chronic aortic dissection, 11 patients had an aneurysm and one had a penetrating ulcer. Fourteen patients had disease in aortic arch zone 0, six in zone 1 and ten in zone 2. Twenty-five patients had undergone previous aortic surgery and 24 required surgical revascularization of the left subclavian artery. Technical success was achieved in 27 of 30 patients. Four patients had an endoleak (type Ia, 1; type II, 3). The in-hospital mortality rate was three of 30. Mean length of follow-up was 12·0 (range 1·0–67·8) months, during which time 12 patients required an aortic-related reintervention.

Conclusion
Repair of aortic arch pathology using branched stent-grafting appears feasible. Before widespread adoption of this technology, further studies are required to standardize the technique and identify which patients are most likely to benefit.
Augmented reality experimentation on oxygen gas generation from hydrogen peroxide and bleach reaction
Authors: Gan Hong Seng , Tee Nicholas Yee Kwang , Bin Mamtaz Mohammad Raziun , Xiao Kevin , Cheong Brandon Huey‐Ping , Liew Oi Wah , Ng Tuck Wah 
Published: February 2018

AbstractThe appreciation and understanding of gas generation through processes is vital in biochemical education. In this work, an augmented reality tool is reported to depict the redox reaction between hydrogen peroxide and sodium hypochlorite solutions, two ubiquitous oxidizing agents, to create oxygen, a combustible gas. As it operates out of smartphones or tablets, students are able to conduct the exercise collaboratively, respond in a manner similar to an actual physical experiment, and able to depict the oxygen volume changes in relation to the volume of hydrogen peroxide of different concentrations used. The tool offers to help students acquire bench skills by limiting handing risks and to mitigate possible student anxiety on handling chemical materials and implements in the laboratory. The feedback received from Year 11 and 12 high school student participants in an outreach exercise indicate the overall effectiveness of this tool. © 2018 by The International Union of Biochemistry and Molecular Biology, 46(3):245–252, 2018.