bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebrospinal Fluid Orexin Levels and Nocturnal Sleep Disruption in Alzheimer’s Disease Patients Showing Neuropsychiatric Symptoms
Authors: Liguori Claudio , Mercuri Nicola Biagio , Nuccetelli Marzia , Izzi Francesca , Bernardini Sergio , Placidi Fabio 
Published: October 2018

Background: Alzheimer’s disease (AD) is the most common form of dementia. It is characterized by a progressive deterioration of cognition, frequently associated with neuropsychiatric symptoms (NPS). Among NPS, sleep disturbances often affect AD patients. Orexinergic system dysregulation has been associated with sleep impairment in AD patients. Objective: The present study investigated CSF orexin levels in AD patients and their relationship with both NPS, measured by the neuropsychiatric inventory (NPI), and sleep, measured via polysomnography. Methods: This is a secondary analysis of a previous study investigating CSF biomarkers, sleep impairment and cognitive decline in AD patients. AD patients completing the NPI were included in this analysis and distributed in two groups based on the presence (NPI score ≥4, AD/NPS+) or absence (NPI score <4, AD/NPS–) of NPS. Results: Twenty-two AD patients constituted the AD/NPS+ group and 20 patients constituted the AD/NPS–group. We observed higher CSF orexin levels in AD/NPS+ than AD/NPS–patients. Moreover, AD/NPS+ showed a more fragmented and the reduction of REM sleep compared to AD/NPS–patients. Notably, higher NPI scores correlated with a more altered sleep structure, higher CSF orexin levels and lower MMSE scores. Conclusion: This study documented that AD patients showing NPS present a more fragmented sleep coupled with higher CSF orexin levels compared to AD patients not affected by NPS. This finding showing the increased orexinergic tone in AD patients affected by NPS suggests the possible influence of the orexinergic system dysregulation not only on sleep impairment but also on neurobehavioral disturbances.
A study of the MR imaging manifestations with injection of sedative at the buttocks in pediatric patients
Authors: Li Xiaobo , Jiang Liuqing , Chen Lifang , lei Yu , Xu Benhua , Liu Biying , Li Sicong 
Published: October 2018

BACKGROUND: During the MRI examination, pediatric patients sleep under the sedation so that the image artifacts caused by the patient motion could be minimized. However, the sedative injection at the buttocks might cause a difficulty in the diagnosis of the buttock diseases using the MRI manifestations. OBJECTIVE: This study aims to explore the imaging characteristics of MR for the pediatric patients with the sedative injected at the buttocks in order to correctly diagnose the diseases. METHODS: MR imaging data of 64 pediatric patients injected with the sedative at the buttocks were retrospectively collected, including 8 cases of buttock disease. The imaging manifestations were analyzed and compared. RESULTS: Out of 64 patients, 8 were diagnosed as the buttock diseases. MR imaging manifestations of the sedatives injected at the buttocks were the locally patchy and streaky long T1 and long T2 signals and were different from what were shown for the normal tissues and diseases. CONCLUSION: The sedative injected at the buttocks has the MRI manifestations different from the normal tissues and diseases. Correctly understanding the MRI manifestations for the pediatric patients with the injection of sedative at the buttocks would reduce the chances of the misdiagnosis on the diseases.
Organization of medical care for children in Ukraine (review of literature)
Authors: Trokhimchuk V. V. , Belyaeva O. I. , Unhurian L. M. 
Published: October 2018

The realization of high quality medical measures for protecting children’s health remains an important issue at the stage of reforming the domestic medicine. The aim of this work was to study and analyze the system of medical aid for children in Ukraine. The research focused on normative-legal acts regulating the organization of medical aid for children. The research methods are informative, retrospective, historical, logical and analytical.
The analysis of normative-legal documents regulating the organization of rendering of medical aid for children established their formality and economic groundlessness.
According to January 2017, only 35 documents were included into the Registry of medical technological documents in the direction of «Pediatrics». It means that many children’s pathological states are not covered by standardization, what reduces the quality of medical aid.
The national programs for the improvement of health status of children remained unrealized due to the lack of funding, ill-coordinated links between program implementers, the lack of effective monitoring of the quality and results of realizing the state programs. The implementation result of IMChI strategy was the reduction of mortality rate in children of different age groups in the pilot regions. In terms of reforming the combined model (model III) is the most effective and acceptable for pediatric care rendering.
The population expenses reach nearly half of the total funding of the sector, what demonstrates the inconsistencies between the real state of children’s assurance in the health care system of Ukraine and national normative acts.
It was determined the necessity of structural reorganization of the system, the optimization of beds number, the increase of medical care funding from state and local budgets, the raising of resource efficiency of health care system and the continued development and implementation of modern protocols (standards) for the treatment of children pathologies.
Logistic outsourcing in pharmacy. the theory and practice
Authors: Bilous M. V. , Shmatenko O. P. , Ryzhov O. A. , Raikova T. S. , Drozdov D. V. 
Published: October 2018

Today, the introduction and application of a logistics approach to resource management allows pharmaceutical companies to increase their social, environmental and economic efficiency.
The article is aimed to research the essence of the concept, types and party of logistic outsourcing in practical pharmacy. To reach the aimreview of foreign and domestic scientific sources and the existing legal framework of Ukraine on this issue have been analyzed. Investigation methods were bibliographic and analytical ones.
The results of these studies indicate the today outsourcing is one of the main logistics strategies of domestic pharmaceutical companies, which is actively used in the sphere of IT-technologies and warehouse services. At the same time for ensuring high-quality providing outsourcing services, a legal and regulatory framework is needed that standardizes the interaction between firm customer and the outsourcer, also the development of standards for the provision of services of a certain type of outsourcing. Wide introduction of logistics outsourcing, as a modern form of optimization of logistics business processes, requires the formation of professional competence among future pharmacists in pharmaceutical logistics, its tools and strategies, i.e. training of competitive professionals capable of working in various directions of practical pharmacy.
Introduction of the topic «Logistic outsourcing in practical pharmacy» in the educational process of students of pharmaceutical faculties (university), pharmacists-interns and pharmacists at the postgraduate level of training is necessary. It will improve the theoretical and practical training of future specialist pharmaceutists and will allow them to apply the knowledge which would be gained in the future in logistics outsourcing in the activities of pharmaceutical companies.
PENGEMBANGAN MUTU PENDIDIKAN MADRASAH ALIYAH DAN HUBUNGANNYA DENGAN KINERJA KEPALA SEKSI PENDIDIKAN
Authors: Aisyah Siti , Jamaluddin Jamaluddin 
Published: October 2018

Fenomena rendahnya mutu lembaga pendidikan harus dijadikan perhatian para manajer lembaga pendidikan, baik dan tingkat manajemen puncak (pejabat pemerintah di bidang pendidikan) maupun oleh para pengelola langsung lembaga pendidikan agar upaya-upaya meraih mutu pendidikan dapat dicapai secara optimal.
Tujuan penelitian ini adalah untuk mengetahui hubungan antara sub-sub pengembangan mutu (input, proses, dan output) terhadap mutu pendidikan dan kinerja Kepala Seksi Pendidikan Madrasah Aliyah Kabupaten Aceh Tengah.
Penelitian ini menggunakan metode analisis data regresi linier berganda, pengujian signifikan simultan dan pengujian signifikan parsial. Jumlah sampel yang digunakan adalah 219 orang responden. Teknik pengumpulan data dilakukan dengan memberikan daftar pertanyaan (kuesioner) kepada responden dan penentuan sampel menggunakan Purposive Sampling. Hasil penelitian menunjukkan bahwa secara parsial sub pengembangan mutu input tidak berpengaruh terhadap mutu pendidikan yang artinya sumber daya (manusia dan kelengkapannya) tidak berpengaruh bagi mutu pendidikan pada penelitian ini. Sub pengembangan mutu proses dan output berpengaruh terhadap mutu pendidikan yang artinya proses yang berlangsung dan hasilnya mempunyai pengaruh bagi mutu pendidikan pada penelitian ini, serta sub-sub pengembangan mutu (input, proses, dan output secara keseluruhan) berpengaruh terhadap kinerja Kepala Seksi Pendidikan Madrasah Aliyah Kabupaten Aceh Tengah dan mutu pendidikan berpengaruh terhadap kinerja Kepala Seksi Pendidikan Madrasah Aliyah Kabupaten Aceh Tengah.
Reciprocal scope revisited
Authors: Haug Dag Trygve Truslew , Dalrymple Mary 
Published: October 2018

The most influential approaches to reciprocals (Heim, Lasnik and May 1991, Dalrymple et al. 1998) involve a scoping operator, but there are good arguments by Murray (2008) and Dotlačil (2013) that reciprocals do not involve distributive quantification but are instead pronouns with both coference and noncoreference requirements. However, the latter analyses cannot straighforwardly account for apparent scopal variability in complex sentences with reciprocals. In this paper we extend the pronominal analysis of reciprocals to long distance cases by extending the original plural CDRT (Brasoveanu 2007) analysis with ideas from partial CDRT (Haug 2014).
Than clauses as embedded questions
Authors: Fleisher Nicholas 
Published: October 2018

Quantifiers in comparative than clauses often appear to take scope at the matrix level, a phenomenon that has spawned a large recent literature. Here I reopen an old line of investigation that seeks illumination in the strikingly similar behavior of quantifiers in embedded questions. A novel observation in this connection is that English clausal comparatives support quantificational variability effects. I explore the possibility of treating than clauses as embedded questions, sketching two implementations, and weigh this type of analysis against recent approaches that invoke degree pluralities. I also discuss multiple-wh configurations in clausal comparatives.
Properties and Occurrence Rates for Kepler Exoplanet Candidates as a Function of Host Star Metallicity from the DR25 Catalog
Authors: Narang Mayank , Manoj P. , Furlan E. , Mordasini C. , Henning Thomas , Mathew Blesson , Banyal Ravinder K. , Sivarani T. 
Published: October 2018

Abstract
Correlations between the occurrence rate of exoplanets and their host star properties provide important clues about the planet formation process. We studied the dependence of the observed properties of exoplanets (radius, mass, and orbital period) as a function of their host star metallicity. We analyzed the planetary radii and orbital periods of over 2800 Kepler candidates from the latest Kepler data release, DR25 (Q1–Q17), with revised planetary radii based on Gaia DR2 as a function of host star metallicity (from the Q1–Q17 (DR25) stellar and planet catalog). With a much larger sample and improved radius measurements, we are able to reconfirm previous results in the literature. We show that the average metallicity of the host star increases as the radius of the planet increases. We demonstrate this by first calculating the average host star metallicity for different radius bins and then supplementing these results by calculating the occurrence rate as a function of planetary radius and host star metallicity. We find a similar trend between host star metallicity and planet mass: the average host star metallicity increases with increasing planet mass. This trend, however, reverses for masses >4.0 M
J: host star metallicity drops with increasing planetary mass. We further examined the correlation between the host star metallicity and the orbital period of the planet. We find that for planets with orbital periods less than 10 days, the average metallicity of the host star is higher than that for planets with periods greater than 10 days.
The 2016 Reactivations of the Main-belt Comets 238P/Read and 288P/(300163) 2006 VW139*
Authors: Hsieh Henry H. , Ishiguro Masateru , Kim Yoonyoung , Knight Matthew M. , Lin Zhong-Yi , Micheli Marco , Moskovitz Nicholas A. , Sheppard Scott S. , Thirouin Audrey , Trujillo Chadwick A. 
Published: October 2018

Abstract
We report observations of the reactivations of the main-belt comets (MBCs) 238P/Read and 288P/(300163) 2006 VW139 that also track the evolution of each object’s activity over several months in 2016 and 2017. We additionally identify and analyze archival SDSS data showing 288P to have been active in 2000, meaning that both 238P and 288P have now each been confirmed to be active near perihelion on three separate occasions. From data obtained of 288P from 2012–2015 when it appeared inactive, we find best-fit R-band H, G phase function parameters of H

R
= 16.80 ± 0.12 mag and G

R
= 0.18 ± 0.11, corresponding to effective component radii of r

c
= 0.80 ± 0.04 km, assuming a binary system with equally sized components. Fitting linear functions to ejected dust masses inferred for 238P and 288P soon after their observed reactivations in 2016, we find an initial average net dust production rate of

kg s−1 and a best-fit start date of 2016 March 11 (when the object was at a true anomaly of ν = −63°) for 238P, and an initial average net dust production rate of

kg s−1 and a best-fit start date of 2016 August 5 (when the object was at ν = −27°) for 288P. Applying similar analyses to archival data, we find similar start points for previous active episodes for both objects, suggesting that minimal mantle growth or ice recession occurred between the active episodes in question. Some changes in dust production rates between active episodes are detected, however. More detailed dust modeling is suggested to further clarify the process of activity evolution in MBCs.
Generation of Turbulence in Colliding Reconnection Jets
Authors: Pucci Francesco , Matthaeus William H. , Chasapis A. , Servidio Sergio , Sorriso-Valvo L. , Olshevsky V. , Newman D. L. , Goldman M. V. , Lapenta Giovanni 
Published: October 2018

Abstract
The collision of magnetic reconnection jets is studied by means of a three-dimensional numerical simulation at the kinetic scale, in the presence of a strong guide field. We show that turbulence develops due to the collision of jets, producing several current sheets in reconnection outflows, aligned with the guide field direction. The turbulence is mainly two-dimensional, with stronger gradients in the plane perpendicular to the guide field and low wave-like activity in the parallel direction. First, we provide a numerical method to isolate the central turbulent region. Second, we analyze the spatial second-order structure function and prove that turbulence is confined in this region. Finally, we compute local magnetic and electric frequency spectra, finding a trend in the subion range that differs from typical cases for which the Taylor hypothesis is valid, as well as wave activity in the range between ion and electron cyclotron frequencies. Our results are relevant to understand observed collisions of reconnection jets in space plasmas.
The Missing Satellites of the Magellanic Clouds? Gaia Proper Motions of the Recently Discovered Ultra-faint Galaxies
Authors: Kallivayalil Nitya , Sales Laura V. , Zivick Paul , Fritz Tobias K. , Del Pino Andrés , Sohn Sangmo Tony , Besla Gurtina , van der Marel Roeland P. , Navarro Julio F. , Sacchi Elena 
Published: October 2018

Abstract
According to LCDM theory, hierarchical evolution occurs on all mass scales, implying that satellites of the Milky Way should also have companions. The recent discovery of ultra-faint dwarf galaxy candidates in close proximity to the Magellanic Clouds provides an opportunity to test this theory. We present proper motion (PM) measurements for 13 of the 32 new dwarf galaxy candidates using Gaia data release 2. All 13 also have radial velocity measurements. We compare the measured 3D velocities of these dwarfs to those expected at the corresponding distance and location for the debris of a Large Magellanic Cloud (LMC) analog in a cosmological numerical simulation. We conclude that four of these galaxies (Hor1, Car2, Car3, and Hyi1) have come in with the Magellanic Clouds, constituting the first confirmation of the type of satellite infall predicted by LCDM. Ret2, Tuc2, and Gru1 have velocity components that are not consistent within 3σ of our predictions and are therefore less favorable. Hya2 and Dra2 could be associated with the LMC and merit further attention. We rule out Tuc3, Cra2, Tri2, and Aqu2 as potential members. Of the dwarfs without measured PMs, five of them are deemed unlikely on the basis of their positions and distances alone being too far from the orbital plane expected for LMC debris (Eri2, Ind2, Cet2, Cet3, and Vir1). For the remaining sample, we use the simulation to predict PMs and radial velocities, finding that Phx2 has an overdensity of stars in DR2 consistent with this PM prediction.
First Spectroscopic Study of a Young Quasar
Authors: Eilers Anna-Christina , Hennawi Joseph F. , Davies Frederick B. 
Published: October 2018

Abstract
The quasar lifetime t
Q is one of the most fundamental quantities for understanding quasar evolution and the growth of supermassive black holes (SMBHs), but remains uncertain by several orders of magnitude. In a recent study we uncovered a population of very young quasars (t
Q ≲ 104–105 yr), based on the sizes of their proximity zones, which are regions of enhanced Lyα forest transmission near the quasar resulting from its own ionizing radiation. The presence of such young objects poses significant challenges to models of SMBH formation, which already struggle to explain the existence of SMBHs (∼109
M
⊙) at such early cosmic epochs. We conduct the first comprehensive spectroscopic study of the youngest quasar known, SDSS J1335+3533 at z = 5.9012, whose lifetime is t
Q = 103.0±0.8 yr (95% confidence). A careful search of our deep optical and near-infrared spectra for H i and metal absorption lines allows us to convincingly exclude the possibility that its small proximity zone results from an associated absorption system rather than a short lifetime. From the Mg ii emission line we measure a black hole mass

, implying an Eddington ratio of

—comparable to other co-eval quasars of similar luminosity. The only possible anomaly associated with SDSS J1335+3533's youth are its weak emission lines, but larger samples are needed to shed light on the potential causality. We discuss the implications of short lifetimes for various SMBH growth and formation scenarios, and argue that future observations of young quasars with the James Webb Space Telescope could distinguish between them.
Stripping of the Hot Gas Halos in Member Galaxies of Abell 1795
Authors: Wagner Cory R. , McDonald Michael , Courteau Stéphane 
Published: October 2018

Abstract
The nearby cluster Abell 1795 is used as a testbed to examine whether hot gas in cluster galaxies is stripped by the ram pressure of the intracluster medium (ICM). The expected X-ray emission in and around Abell 1795 galaxies is likely dominated by the ICM, low-mass X-ray binaries, active galactic nuclei, and hot gas halos. In order to constrain these components, we use archival Chandra X-ray Observatory and Sloan Digital Sky Survey observations of Abell 1795 and identify 58 massive (M
⋆ > 1010
M
⊙) spectroscopic cluster members within 5′ of the Chandra optical axis. X-ray images at 0.5–1.5 and 4–8 keV were created for each cluster member and then stacked into two clustercentric radius bins: inner (0.25 < R
clust/R
500 < 1) and outer (1 < R
clust/R
500 < 2.5). Surface brightness profiles of inner and outer cluster members are fit using Markov chain Monte Carlo sampling in order to generate model parameters and measure the 0.5–1.5 keV luminosities of each model component. Leveraging effective total Chandra exposure times of 3.4 and 1.7 Ms for inner and outer cluster members, respectively, we report the detection of hot gas halos, in a statistical sense, around outer cluster members. Outer members have 0.5–1.5 keV hot halo luminosities (

) that are six times larger than the upper limit for inner cluster members (L
X < 1.3 × 1039 erg s−1). This result suggests that the ICM is removing hot gas from the halos of Abell 1795 members as they fall into the cluster.
Wide-field Optical Spectroscopy of Abell 133: A Search for Filaments Reported in X-Ray Observations
Authors: Connor Thomas , Kelson Daniel D. , Mulchaey John , Vikhlinin Alexey , Patel Shannon G. , Balogh Michael L. , Joshi Gandhali , Kraft Ralph , Nagai Daisuke , Starikova Svetlana 
Published: October 2018

Abstract
Filaments of the cosmic web have long been associated with the threadlike structures seen in galaxy redshift surveys. However, despite their baryon content being dominated by hot gas, these filaments have been an elusive target for X-ray observations. Recently, detections of filaments in very deep (2.4 Ms) observations with Chandra were reported around Abell 133 (z = 0.0559). To verify these claims, we conducted a multiobject spectrographic campaign on the Baade 6.5 m telescope around Abell 133; this resulted in a catalog of ∼3000 new redshift measurements, of which 254 are of galaxies near the cluster. We investigate the kinematic state of Abell 133 and identify the physical locations of filamentary structure in the galaxy distribution. Contrary to previous studies, we see no evidence that Abell 133 is dynamically disturbed; we reject the hypothesis that there is a kinematically distinct subgroup (p = 0.28) and find no velocity offset between the central galaxy and the cluster (

). The spatial distribution of galaxies traces the X-ray filaments, as confirmed by angular cross-correlation with a significance of ∼5σ. A similar agreement is found in the angular density distribution, where two X-ray structures have corresponding galaxy enhancements. We also identify filaments in the large-scale structure of galaxies; these filaments approach the cluster from the direction the X-ray structures are seen. While more members between R
200 and 2 × R
200 are required to clarify which large-scale filaments connect to the X-ray gas, we argue that this is compelling evidence that the X-ray emission is indeed associated with cosmic filaments.