bluuebunny/crossref_metadata_2025_split huggingface dataset:
ЕФЕКТИВНІСТЬ ГІСТЕРОРЕЗЕКТОСКОПІЇ У ЖІНОК З БЕЗПЛІДДЯМ НА ФОНІ ЛЕЙОМІОМИ МАТКИ В ПРОГРАМАХ ДОПОМІЖНИХ РЕПРОДУКТИВНИХ ТЕХНОЛОГІЙ
Authors: Khmil S. V. , Drozdovska Yu. B. , Khmil M. S. , Chudiyovych N. Ya. 
Published: May 2019

Мета: вивчення ефективності гістерорезектоскопії у жінок із безпліддям на фоні лейоміоми матки в програмах допоміжних репродуктивних технологій.
Матеріали і методи. Рандомізоване клінічне дослідження проведено серед 58 жінок, які проходили лікування безпліддя шляхом використання програм допоміжних репродуктивних технологій. Вибірку було поділено на 2 групи. І групу (дослідну) склала 41 жінка з лейоміомою матки з субмукозним та субмукозно-інтрамуральним розташуванням міоматозних вузлів та невдалими спробами екстракорпорального запліднення в анамнезі, цим жінкам запропоновано гістерорезектоскопію як підготовку перед програмами допоміжних репродуктивних технологій. ІІ групу (контрольну) – 17 жінок із лейоміомою матки з субмукозно-інтрамуральним розташуванням міоматозних вузлів, які відмовились від гістерорезектоскопії. У цьому дослідженні були включені пари виключно з жіночими формами безпліддя.
Результати. Доведено ефективність гістерорезектоскопії на результат циклів екстракорпорального першої спроби екстракорпорального запліднення), ранні мимовільні викидні спостерігали в 2 жінок (11,8 %), у 14 жінок вагітність закінчилась терміновими пологами (82,4 %) та в однієї жінки передчасними (5,9 %). У ІІ групі (контрольній) з 17 пацієнток вагітність настала в 6 жінок (35,3 %), 3 випадки ранніх мимовільних викиднів (50 %), термінові пологи у 3 жінок (50 %).
Висновки. Лейоміома матки в основному є причиною безпліддя за рахунок механічного фактора. Гістерорезектоскопія є оптимальним методом прегравідарної підготовки у жінок із лейоміомою матки, які проходять лікування безпліддя шляхом використання допоміжних репродуктивних технологій. Гістерорезектоскопія є органозберігаючою операцією, що має ряд переваг: легкий післяопераційний період, відсутність спайкового процесу, що, в свою чергу, підвищує частоту настання та виношування вагітності.
Myocardial Fibrosis in Classical Low-Flow, Low-Gradient Aortic Stenosis
Authors: Rosa Vitor E.E. , Ribeiro Henrique B. , Sampaio Roney O. , Morais Thamara C. , Rosa Marcela E.E. , Pires Lucas J.T. , Vieira Marcelo L.C. , Mathias Wilson , Rochitte Carlos E. , de Santis Antonio S.A.L. , Fernandes Joao Ricardo C. , Accorsi Tarso A.D. , Pomerantzeff Pablo M.A. , Rodés-Cabau Josep , Pibarot Philippe , Tarasoutchi Flavio 
Published: May 2019

Background
Few data exist on the degree of interstitial myocardial fibrosis in patients with classical low-flow, low-gradient aortic stenosis (LFLG-AS) and its association with left ventricular flow reserve (FR) on dobutamine stress echocardiography. This study sought to evaluate the diffuse interstitial fibrosis measured by T1 mapping cardiac magnetic resonance technique in LFLG-AS patients with and without FR.

Methods
Prospective study including 65 consecutive patients (41 LFLG-AS [mean age, 67.1±8.4 years; 83% men] and 24 high-gradient aortic stenosis used as controls) undergoing dobutamine stress echocardiography to assess FR and cardiac magnetic resonance to determine the extracellular volume (ECV) fraction of the myocardium, indexed ECV (iECV) to body surface area and late gadolinium enhancement.

Results

Interstitial myocardial fibrosis measured by iECV was higher in patients with LFLG-AS with and without FR as compared with high-gradient aortic stenosis (35.25±9.75 versus 32.93±11.00 versus 21.19±6.47 mL/m
2
, respectively;
P
<0.001). However, both ECV and iECV levels were similar between LFLG-AS patients with and without FR (
P
=0.950 and
P
=0.701, respectively). Also, FR did not correlate significantly with ECV (r=−0.16,
P
=0.31) or iECV (r=0.11,
P
=0.51). Late gadolinium enhancement mass was also similar in patients with versus without FR but lower in high-gradient aortic stenosis (13.3±10.2 versus 10.5±7.5 versus 4.8±5.9 g, respectively;
P
=0.018).

Conclusions
Patients with LFLG-AS have higher ECV, iECV, and late gadolinium enhancement mass compared with high-gradient aortic stenosis. Moreover, among patients with LFLG-AS, the degree of myocardial fibrosis was similar in patients with versus those without FR. These findings suggest that diffuse myocardial fibrosis may not be the main factor responsible for the absence of FR in LFLG-AS patients.
Right Ventricular Function Evaluated by Tricuspid Annular Plane Systolic Excursion Predicts Cardiovascular Death in the General Population
Authors: Modin Daniel , Møgelvang Rasmus , Andersen Ditte Madsen , Biering‐Sørensen Tor 
Published: May 2019

Background

Cardiovascular disease remains a leading cause of death. Right ventricular (
RV
) function is a strong predictor of outcome in many cardiovascular diseases, but its significance is often neglected. Little is known about the prognostic value of
RV
systolic function in the general population. Therefore, we aimed to determine the prognostic value of
RV
systolic function, evaluated by tricuspid annular plane systolic excursion (
TAPSE
), in predicting cardiovascular death (
CVD
) in the general population.

Methods and Results

A total of 1039 participants from the general population without heart failure or atrial fibrillation had an echocardiogram performed and
TAPSE
measured. The end point was
CVD
. During a median follow‐up of 12.7 years (interquartile range, 12.0–12.9 years), 69 participants (6.6%) experienced
CVD
, whereas 162 participants (15.6%) experienced non‐CVD. Decreasing
RV
systolic function, assessed as
TAPSE
, was a univariable predictor of
CVD
(hazard ratio, 1.13; 95%
CI
, 1.07–1.20;
P
<0.001, per 1‐mm decrease).
TAPSE
remained an independent predictor of
CVD
after adjusting for clinical and echocardiographic parameters (hazard ratio, 1.08; 95%
CI
, 1.01–1.15;
P
=0.017, per 1‐mm decrease). Furthermore, in net reclassification analysis, decreasing
RV
systolic function, assessed as
TAPSE,
significantly improved risk classification with respect to
CVD
when added to established cardiovascular risk factors from the Systematic Coronary Risk Evaluation chart or a modified version of the American Heart Association/American College of Cardiology Pooled Cohort Equation. Decreasing
RV
systolic function, assessed as
TAPSE
, did not predict non‐CVD, indicating specificity for
CVD
.

Conclusions

RV
systolic function, as assessed by
TAPSE
, is associated with
CVD
in the general population. In the general population, assessment of
RV
systolic function may provide novel prognostic information about the risk of
CVD
.
Using Multisource Satellite Data to Assess Recent Snow-Cover Variability and Uncertainty in the Qinghai–Tibet Plateau
Authors: Jiang Yingsha , Chen Fei , Gao Yanhong , Barlage Michael , Li Jianduo 
Published: May 2019

Abstract
Snow cover in the Qinghai–Tibet Plateau (QTP) is a critical component in the water cycle and regional climate of East Asia. Fractional snow cover (FSC) derived from five satellite sources [the three satellites comprising the multisensor synergy of FengYun-3 (FY-3A/B/C), the Moderate Resolution Imaging Spectroradiometer (MODIS), and the Interactive Multisensor Snow and Ice Mapping System (IMS)] were intercompared over the QTP to examine uncertainties in mean snow cover and interannual variability over the last decade. A four-step cloud removal procedure was developed for MODIS and FY-3 data, which effectively reduced the cloud percentage from about 40% to 2%–3% with an error of about 2% estimated by a random sampling method. Compared to in situ snow-depth observations, the cloud-removed FY-3B data have an annual classification accuracy of about 94% for both 0.04° and 0.01° resolutions, which is higher than other datasets and is recommended for use in QTP studies. Among the five datasets analyzed, IMS has the largest snow extent (22% higher than MODIS) and the highest FSC (4.7% higher than MODIS), while the morning-overpass MODIS and FY-3A/C FSC are similar and are around 5% higher than the afternoon-overpass FY-3B FSC. Contrary to MODIS, IMS shows increasing variability in snow cover and snow duration over the last decade (2006–17). Differences in variabilities of FSC and snow duration between products are greater at 5–6 km than lower elevations, with seasonal snow-cover change showing the largest uncertainty in snowmelt date.
Use of the Earth’s Surface as a Reference to Correct Airborne Nadir-Looking Radar Radial Velocity Measurements for Platform Motion
Authors: Ellis Scott M. , Tsai Peisang , Burghart Christopher , Romatschke Ulrike , Dixon Michael , Vivekanandan Jothiram , Emmett Jonathan , Loew Eric 
Published: May 2019

AbstractA technique for correcting radar radial velocity Vr in airborne, nadir-pointing radar data using the surface of Earth as a reference is proposed and tested. Operating airborne Doppler radars requires correcting the radial velocity for platform motion. This can be accomplished with accurate beam-pointing and platform motion measurements. However, there are often residual pointing errors due to drift in inertial navigation systems (INS) and/or errors in platform-relative pointing. The technique proposed here takes advantage of the fact that the surface is stationary and the mean of the measured Vr at the surface should be 0 m s−1. Therefore, if a good estimate of the mean is made, it can be subtracted from the measured Vr to correct for errors due to residual pointing errors. The data contain many independent deviations from 0 m s−1 due to various causes, including measurement variance and large deviations due to surface features. These deviations must be filtered out of before the surface reference can be applied to correct the Vr data. A two-step filtering process was developed and tested. The first step removes large deviations in and the second step removes the measurement noise. The technique was examined using data from three field campaigns and was found to improve the quality of Vr in all cases. The Vr bias was removed and the variance was substantially reduced. The approach is generally applicable to nadir-pointing airborne radar data.
Female breast cancers (T1-2, N0, M0, HR+, HER2−) with an intermediate genetic-based recurrence risk: a real-world estimate in Italy
Authors: Crocetti Emanuele , Ravaioli Alessandra , Amadori Dino , Mancini Silvia , Vattiato Rosa , Giuliani Orietta , Baldacchini Flavia , Falcini Fabio 
Published: May 2019

Objectives: Prognostic definition and treatment of breast cancer are supported by multigene testing. A recent trial (TAILORx) provided evidence against the use of adjuvant chemotherapy in early breast cancer (HR+ HER2−) with an intermediate result (11–25) in a multigene test (Oncotype DX). These results consequently fueled great discussion among oncologists. We aimed to estimate the burden of Italian incident breast cancer patients who, each year, may be involved in such decision-making. Methods: We used the data collected in the Romagna Cancer Registry to estimate the number of cases with the inclusion criteria of the TAILORx trial. Adjustments based on geographical variability in breast cancer incidence in Italy were applied to national estimates. Cases were estimated by Oncotype DX recurrence risk groups: ⩽10, 11–25, ⩾26. We also estimated the proportion of grade 1, 2, or 3 disease among breast cancer cases. Results: An overall 52,300 breast cancer cases were estimated to be diagnosed in Italy in 2018. Of these, 18,225 fit the TAILORx inclusion criteria: 3,025 were expected to have a low risk of recurrence (⩽10), 11,536 (63.3% of all cases) an intermediate risk (11–25), and 3,664 a high risk (⩾26). Among the group at intermediate risk, who may benefit from less aggressive therapy, 2,414 were estimated to have grade 1 disease, 7,618 grade 2, and 1,983 grade 3. Conclusions: This article provides reliable estimates on the burden of Italian women with breast cancer who, once tested with multigene testing, could potentially have their treatment changed to hormone therapy only.
Is Microfracture Necessary? Acetabular Chondrolabral Debridement/Abrasion Demonstrates Similar Outcomes and Survival to Microfracture in Hip Arthroscopy: A Multicenter Analysis
Authors: Hevesi Mario , Bernard Christopher , Hartigan David E. , Levy Bruce A. , Domb Benjamin G. , Krych Aaron J. 
Published: May 2019

Background:Hip arthroscopy is becoming more advanced and commonly performed. However, significant controversy exists regarding whether high-grade acetabular cartilage lesions should be treated with debridement/abrasion or microfracture. In addition, patients treated with microfracture are subject to extended protected weightbearing rehabilitation to mitigate risk of subchondral plate fracture and to protect fibrocartilage tissue formation.Purpose:To determine the midterm patient-reported outcomes and failure rate of patients with grade 3 and 4 acetabular labrum articular disruption (ALAD) lesions managed with debridement/abrasion or microfracture.Study Design:Cohort study; Level of evidence, 3.Methods:Primary arthroscopic labral repair cases at 2 centers from November 2008 to April 2016 were reviewed for patients aged <55 years with unipolar ALAD grade 3 and 4 chondrolabral acetabular delamination. Patients undergoing microfracture and debridement/abrasion were compared using the visual analog pain scale (VAS), modified Harris Hip Score (mHHS), and Hip Outcome Score–Sports-Specific Subscale (HOS-SSS) to determine predictors of outcomes and failure.Results:A total of 113 hips in 110 patients (66 males, 44 females; mean age, 34.5 ± 1.1 years) undergoing debridement/abrasion (n = 82) or microfracture (n = 31) were followed for a mean of 4.9 years (range, 2.0-8.5 years). Lesion size was not statistically different between the debridement/abrasion (1.3 ± 1.0 cm2) and microfracture cohorts (1.4 ± 1.0 cm2) ( P = .47). Patients undergoing debridement/abrasion achieved 3.6-point mean improvements in VAS ( P < .01), 21.2-point improvements in mHHS ( P < .01), and 25.4-point improvements in HOS-SSS ( P < .01), which were not significantly different from those observed in microfracture patients ( P≥ .20). The 5-year rate of survival free of revision surgery was 84.0% in the debridement/abrasion group and 85.6% in the microfracture group ( P = .78). The cartilage treatment technique was found not to be predictive of revision risk during both univariate (hazard ratio [HR], 1.01; P = .98) and multivariate (HR, 0.93; P = .90) analysis accounting for patient age, lesion grade, and acetabular coverage.Conclusion:Patients undergoing debridement/abrasion of high-grade unipolar acetabular cartilage lesions demonstrate similar outcome scores and revision rates compared with those of patients undergoing microfracture. These outcomes support the consideration of preferential debridement/abrasion at the discretion of the treating surgeon to optimize recovery while maintaining established positive outcomes after hip arthroscopy.
A retrospective analysis of tumor lysis syndrome management in a quaternary care hospital
Authors: Eng Stephen , Lee Chung-Shien , Ahn Seungjun , Sharma Amy 
Published: May 2019

Purpose Due to an increased use of rasburicase, the study’s purpose was to evaluate both the management of tumor lysis syndrome and the utilization of rasburicase in the hospital system. Additionally, the efficacy of flat dose rasburicase in lowering uric acid levels was evaluated. Based on the study’s findings, the investigators will evaluate the usefulness of implementing a tumor lysis syndrome order set. Methods This study evaluated patients from January 2013 through December 2016 for the rasburicase dose and the tumor lysis syndrome therapy administered. Results Overall, 251 patients were included: prophylactic rasburicase group (n = 125) vs. treatment rasburicase group (n = 126) and of rasburicase 3 mg (R3) group (n = 168) vs. 6 mg (R6) group (n = 83). The prophylactic rasburicase vs. treatment rasburicase group had a significantly lower rate of receiving a xanthine oxidase inhibitor (48.0% vs. 64.3%, p = 0.009), a phosphate binder (6.4% vs. 17.5%, p = 0.007) and an additional dose of rasburicase (20.8% vs. 41.3%, p = 0.001). Intravenous hydration was neither significantly different between the rasburicase groups (p = 0.399) nor between the two rasburicase dosing groups (p = 0.874). Between the rasburicase dosing groups, there was no significant difference in the rate of receiving a xanthine oxidase inhibitor (p = 0.521) or a phosphate binder (p = 0.390). R6 patients had a significantly greater reduction in uric acid change compared to R3 patients (median = −7.9 (−10.1, −5.5) vs. −4.3 (−6.0, −2.7), p < 0.0001). There was no significant difference in uric acid change between the prophylactic rasburicase and treatment rasburicase groups (p = 0.875). Conclusion The study’s findings justified the need to implement a tumor lysis syndrome order set. In the study population, utilizing a flat dosing method was effective for hyperuricemia.
Symmetries of comprehension-based language switch costs in conflicting versus non-conflicting contexts
Authors: Liu Cong , Timmer Kalinka , Jiao Lu , Wang Ruiming 
Published: May 2019

Aims: The present study aimed to investigate the effect of contexts (i.e., non-conflicting context versus conflicting context) on bilingual language switch costs during language comprehension. Methodology: Thirty-two unbalance Chinese-English bilinguals completed a modified comprehension-based language-switching task in two contexts. They made a judgement about the colour meaning of the word. In the non-conflicting context all words were presented in white ink, while in the conflicting context the words were printed in an inconsistent ink colour. Data and analysis: Reaction time and accuracy data were analysed using mixed-effects models. Findings/conclusions: Results showed that the switch costs were larger in the conflicting context than in the non-conflicting context. Further, in the non-conflicting context an asymmetrical switch cost with larger costs for the second language was observed as compared to symmetrical switch costs in the conflicting context. Originality: This is the first study that indicates that bilingual comprehension-based language control adapts flexibly depending on the context, just as during bilingual production. Significance/implications: These findings supported and expanded the classic adaptive control hypothesis.
Longitudinal Outcomes of Women Undergoing Transcatheter Aortic Valve Replacement
Authors: Kilic Arman , Bianco Valentino , Gleason Thomas G. , Lee Joon S. , Schindler John , Navid Forozan , Kliner Dustin , Cavalcante Joao L. , Mulukutla Suresh R. , Sultan Ibrahim 
Published: May 2019

Objective Recent data have suggested that women have a survival benefit at 1-year follow-up. However, long-term gender-based TAVR outcomes are lacking. Methods All patients undergoing isolated TAVR from 2011 to 2017 were included. Patients were stratified by gender. The primary outcomes of the study were 3-year mortality and 3-year hospital readmissions. Multivariable logistic regression analysis was used to evaluate the risk-adjusted impact of gender on TAVR outcomes. Results A total of 1,036 patients were divided into male ( n = 518) and female ( n = 518) cohorts. Women had a borderline significantly increased STS PROM (8.3% ± 5 vs. 7.7% ± 4.4; P = 0.05). The majority of procedures were performed under conscious sedation (male: 89% vs. female: 88%; P = 0.62) and via transfemoral access (male: 81.8% vs. female: 81.4%; P = 0.46). There was no difference in operative (30-day) mortality (male: 15 [3.3%] vs. female: 17 [3.7%]; P = 0.77) or 30-day readmissions (male: 40 [10.8%] vs. female: 44 [12.2%]; P = 0.56). Perioperative blood product usage was higher for women (male: 8.1% vs. female: 14.1%; P = 0.002). There was no significant difference in major vascular complications (male: 0.4% vs. female: 1.0%; P = 0.26) or major bleeding (male: 0.2% vs. female: 0.4%; P = 0.56). Permanent pacemaker placement was higher for males (11.6% vs. 7.0%; P = 0.01). On risk-adjusted multivariable analysis, gender was not a factor associated with mortality (HR 0.99 [0.76 to 1.30]; P = 0.99) or readmission (HR 0.90 [0.72 to 1.14]; P = 0.42) at 5 years. Conclusions There was no difference in survival or readmissions on multivariable analysis for women undergoing TAVR at 3 years. Longitudinal multi-institutional data will be important to validate these findings.
Relationship between haemodynamic changes and outcomes of intracranial aneurysms after implantation of the pipeline embolisation device: a single centre study
Authors: Chen Junfan , Zhang Yisen , Tian Zhongbin , Li Wenqiang , Zhang Qianqian , Zhang Ying , Liu Jian , Yang Xinjian 
Published: May 2019

Background Intracranial aneurysms are increasingly being treated by the placement of flow diverters; however, the factors affecting the outcome of aneurysms treated using flow diverters remain unclarified. Methods The present study investigated 94 aneurysms treated with pipeline embolisation device placement, and used a computational fluid dynamics method to explore the factors influencing the outcome of aneurysms. Results Seventy-six completely occluded aneurysms and 18 incompletely occluded aneurysms were analysed. Before treatment, inflow jets were found in 13 (72.2%) aneurysms in the incompletely occluded group and 34 (44.7%) in the completely occluded group ( P = 0.292). After deployment of the pipeline embolisation device, inflow jets remained in nine (50%) aneurysms in the incompletely occluded group and nine (11.8%) in the completely occluded group ( P = 0.001). In the incompletely occluded group, regions with inflow jets after treatment corresponded with the patent areas shown on follow-up digital subtraction angiography. The mean reduction ratios of velocity in the whole aneurysm and on the neck plane were lower in the incompletely occluded than in the completely occluded group ( P = 0.003; P = 0.017). Multivariate analysis revealed that the only independent risk factors for incomplete aneurysm occlusion were the reduction ratios of velocity (in the whole aneurysm, threshold 0.362, P = 0.005; on the neck plane, threshold 0.273, P = 0.015). Conclusions After pipeline embolisation device placement, reduction ratios of velocity in the whole aneurysm of less than 0.362 and on the neck plane of less than 0.273 are significantly associated with a greater risk of aneurysm incomplete occlusion. In addition, the persistence of inflow jets in aneurysms is associated with incomplete occlusion in the inflow jet area.