bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uji Proximat Daging Ikan Lele yang Dibudidayakan dengan Perbedaan Manajemen Kualitas Air dan Pakan <br><i>[Test Proximat Meat Catfish Cultivated with Differences Water and Feed Quality Management]<i>
Authors: Bimantara Arif 
Published: November 2018

AbstrakIkan lele merupakan salah satu komoditas perikanan budidaya yang popular di Indonesia. Permintaan pasar akan jenis ikan ini yang semakin bertambah menyebabkan pembudidaya lele menggunakan berbagai cara untuk meningkatkan kualitas dan kuantitas produksinya. Penelitian ini bertujuan untuk megetahui hasil uji proksimat daging ikan lele yang dibudidayakan dengan manajemen kualitas air dan pakan yang berbeda meliputi kandungan protein, lemak, air dan abu. Sampel didapatkan dari lima pembudidaya ikan lele yang menggunakan metode pemeliharaan yang berbeda yaitu (1) L1 : pemberian pakan daging ayam dengan pergantian air 3 -5 hari sekali; (2) L2 : pemberian pakan pelet dicampur dengan bahan herbal, penambahan probiotik pada air budidaya dan dilakukan pergantian air setiap hari; (3) L3 : pakan kombinasi pelet dan daging ayam dengan pergantian air 3-5 hari sekali; (4) L4 : pakan pelet tanpa pergantian air; (5) L5 : pakan pelet dicampur multivatimin komersial, penambahan probiotik pada air budidaya dan dilakukan pergantian air 3-5 hari sekali. Daging ikan lele L1 memiliki kandungan air (67,1%) dan protein (14,6%) paling rendah walaupun memiliki kandungan lemak (5,6%) tertinggi dibandingkan sampel perlakuan lain, sedangkan sampel L2 memiliki kandungan protein tertinggi sebesar 17,4% sekaligus memiliki kadar abu paling rendah diantara sampel lainnya sebesar 0,4%. Hasil tersebut menunjukkan bahwa manajemen kualitas air dan pakan mempengaruhi hasil uji proksimat daging ikan lele yang dibudidayakan. AbstractCatfish is one of the most popular aquaculture commodities in Indonesia. The increasing market demand for this fish caused the catfish farmers to apply various methods to improve the quality and quantity of its product. This study aimed to assess the proximate test results of catfish meat cultured in different water quality and feeding management for the parameters protein, fat, water, and ash content. The samples were obtained from five catfish farmers using different culture methods, namely (1) L1: chicken meat feeding with water exchange every 3-5 days; (2) L2: pellets feeding mixed with herbs, probiotics addition to culture water and daily water exchange; (3) L3: combination of pellets and chicken meat feeding with water exchange every 3-5 days; (4) L4: pellets feeding with no water exchange; (5) L5: commercial multivatimin mixed with pellets feeding, probiotics addition to culture water and water exchange every 3-5 days. The L1 catfish meat has the lowest water (67,1%) and protein (14,6%) content, although it has the highest fat content (5,6%) compared to other treatments, while the L2 sample has the highest protein content of 17,4 % as well as the lowest as content among other samples of 0.4%. These results indicate that water quality and feeding management affect the proximate test results of cultured catfish meat.
Advances in Theoretical Studies on the Design of Single Boron Atom Compounds
Authors: Bello Martiniano 
Published: November 2018

Background:
Single Boron Atom Compounds (SBACs) have been used for drug discovery in diseaseassociated
proteins due to the empty p-orbital in the atomic structure of boron, which allows it to experience
diverse binding modes during molecular recognition with a range of proteins.

Objective:
During the molecular recognition process with a protein target, SBACs can assume an anionic tetragonal
arrangement or a neutral trigonal planar structure to produce four possible reversible covalent or non-covalent
binding modes with a protein. However, the development of new SBACs has been hampered by the fact that most
of the force fields present in many of the software packages used in drug design lack the various types of boron
atom parameters.

Methods:
We review in silico studies in which a series of theory-based computational strategies have been used
to overcome the lack of boron parameters in most of the force fields used in drug design.

Results:
The modeling studies discussed in this review have provided substantial insight into the molecular recognition
of SBACs targeting different receptors, including the elucidation of some of the key interactions, which
serve as a guide for the development of selective SBACs.

Conclusion:
Although the strategies employed in many of the studies presented here should serve in the development
of selective SBACs, it is clear that the development of the precise force field parameters, which include
not only the individual atom types but also the entire molecule, is still lacking, yet it is a necessary requirement
for the design of new SBACS as well as for gaining insight into their molecular recognition.
Drug Design of Inhibitors of Alzheimer’s Disease (AD): POM and DFT Analyses of Cholinesterase Inhibitory Activity of β-amino di-Carbonyl Derivatives
Authors: Hadda Taibi Ben , Rauf Abdur , Zgou Hsaine , Senol Fatma Sezer , Orhan Ilkay Erdogan , Mabkhot Yahia Nasser , Althagafi Ismail I. , Farghaly Thoraya A. , Alterary Seham 
Published: November 2018

Background:Since deficit of acetylcholine has been evidenced in the Alzheimer’s disease (AD) patients, cholinesterase inhibitors are currently the most specified drug category for the remediation of AD.Method:In the present study, 16 compounds (1-16) with dicarbonyl skeletons have been synthesized and tested for their inhibitory potential in vitro against AChE and BChE using ELISA microtiter plate assays at 100 μg/mL. Since metal accumulation is related to AD, the compounds were also tested for their metal-chelation capacity.Results and Conclusion:All the investigated dicarbonyl compounds exerted none or lower than 30% inhibition against both cholinesterases, whereas compounds 2, 8 and 11 showed 37, 42, 41% of inhibition towards BChE, being the most active. The highest metal-chelation capacity was observed with compound 8 (53.58 ± 2.06%). POM and DFT analyses are in good harmonization with experimental data.
Bone Invasive Properties of Oral Squamous Cell Carcinoma and its Interactions with Alveolar Bone Cells: An In Vitro Study
Authors: Qallandar Omel Baneen , Ebrahimi Faeza , Islam Farhadul , Wahab Riajul , Qiao Bin , Reher Peter , Gopalan Vinod , Lam Alfred King-yin 
Published: November 2018

Background:Co-culture of cancer cells with alveolar bone cells could modulate bone invasion and destructions. However, the mechanisms of interaction between oral squamous cell carcinoma (OSCC) and bone cells remain unclear.Objective:The aim of this study is to analyse the direct and indirect effects of OSCC cells in the stimulation of osteolytic activity and bone invasion.Methods:Direct co-culture was achieved by culturing OSCC (TCA8113) with a primary alveolar bone cell line. In the indirect co-culture, the supernatant of TCA8113 cells was collected to culture the alveolar bone cells. To assess the bone invasion properties, in vitro assays were performed.Results:The proliferation of co-cultured cancer cells was significantly (p<0.05) higher in comparison to the monolayer control cells. However, the proliferation rates were not significantly different between direct and indirect co-cultured cells with indirect co-cultured cells proliferated slightly more than the direct co-cultured cells. Invasion and migration capacities of co-cultured OSCC and alveolar bone cells enhanced significantly (p<0.05) when compared to that of control monolayer counterparts. Most importantly, we noted that OSCC cells directly co-cultured with alveolar bone cells stimulated pronounced bone collagen destruction. In addition, stem cells and epithelialmesenchymal transition markers have shown significant changes in their expression in co-cultured cells.Conclusion:In conclusion, the findings of this study highlight the importance of the interaction of alveolar bone cells and OSCC cells in co-culture setting in the pathogenesis of bone invasion. This may help in the development of potential future biotherapies for bone invasion in OSCC.
The Added Value of Liquid Antipsychotics: The Case of Quetiapine
Authors: Papazisis Georgios , Siafis Spyridon 
Published: November 2018

Background:Antipsychotic drugs are the cornerstone of schizophrenia treatment and are also indicated for other psychotic and mood disorders. Different antipsychotic drugs and their formulations are available, though liquid forms have been overlooked.Methods:Herein the added value of liquid antipsychotics is reviewed, with a focus on the recently introduced liquid quetiapine, a frequently used antipsychotic.Results:Liquid antipsychotics are easily administrated via the preferable oral route, while compliance under supervised administration is transparent. Liquid forms could be preferred in patients with swallowing difficulties, which are common in elderly patients and often concealed. In this population, the availability of liquid antipsychotics could prevent errors in medication administration, which could possibly render caregivers labile to any harm caused to the patient. Aspiration, however, remains a risk with liquid formulations. Common errors in medication administration are the omission of treatment and alteration of solid oral formulations. Regarding quetiapine, omission of treatment could be associated with non-adherence as well as discontinuation symptoms, while alteration of extended release formulation could alter its pharmacokinetics. Mildly agitated and cooperative patients are another target population of liquid antipsychotics, which can induce fast sedation avoiding involuntary intramuscular injections. The combination of sedative properties and low incidence of extrapyramidal symptoms makes liquid quetiapine a valuable option for these patients, yet the current evidence is limited.Conclusion:The liquid form of quetiapine can facilitate pharmacotherapy of schizophrenia and can be defined as value added medicine bringing key benefits not only to the patients and caregivers but also to the health care system.
Hypothyroidism Alters the Uterine Lipid Levels in Pregnant Rabbits and Affects the Fetal Size
Authors: Rodríguez-Castelán Julia , Zepeda-Pérez Dafne , Méndez-Tepepa Maribel , Castillo-Romano Marlenne , Espíndola-Lozano Marlen , Anaya-Hernández Arely , Berbel Pere , Cuevas-Romero Estela 
Published: November 2018

Background:Hypothyroidism has been related to low-weight births, abortion and prematurity, which have been associated with changes in the content of glycogen and vascularization of the placenta. Since hypothyroidism can cause dyslipidemia, it may affect the lipid content in the uterus affecting the development of fetuses.Objective:To investigate the effect of hypothyroidism on the lipid levels in serum and uterus during pregnancy and their possible association with the size of fetuses.Methods:Adult female rabbits were grouped in control (n = 6) and hypothyroid (n = 6; treated with methimazole for 29 days before and 19 days after copulation). Food intake and body weight were daily registered. At gestational day 19 (GD19), dams were sacrificed under an overdose of anesthesia. Morphometric measures of fetuses were taken. Total cholesterol (TC), triglyceride (TAG), and glucose concentrations were quantified in blood, uterus and ovaries of dams. The expression of uterine 3β- hydroxysteroid dehydrogenase (3β-HSD) was quantified by Western blot.Results:Hypothyroidism reduced food intake and body weight of dams, as well as promoted low abdominal diameters of fetuses. It did not induce dyslipidemia and hyperglycemia at GD19 and did not modify the content of lipids in the ovary. However, it reduced the content of TAG and TC in the uterus, which was associated with uterine hyperplasia and an increased expression of 3β-HSD in the uterus.Conclusion:Hypothyroidism alters the lipid content in the uterus that might subsequently affect the energy production and lipid signaling important to fetal development.
Measuring the Consistency of Quantitative and Qualitative Information in Financial Reports: A Design Science Approach
Authors: Chou Chi-Chun , Chang C. Janie , Chin Chen-Lung , Chiang Wei-Ta 
Published: November 2018

ABSTRACT
This study uses a design science approach to examine the consistency between quantitative financial ratios and qualitative narrative disclosures in the annual reports. To extract information on the tone of unstructured qualitative textual data, we first use the term frequency/inverse document frequency (TFIDF) text mining technique to classify each company's narrative disclosure as either “Positive” or “Negative.” For the quantitative information, we use the K-means method to cluster each company's financial performance data into “Good” or “Poor” groups. Consistency is said to occur when the textual and numerical data form either a “Positive-Good” pair or a “Negative-Poor” pair. The design model is presented in a stepwise fashion and therefore is transparent for evaluation and validation. Our evaluation process demonstrates the feasibility of the design model. The evaluation was conducted using listed semiconductor companies in countries with different levels of market development. The results show that U.S. firms are less likely to exaggerate in their narrative disclosures and are more likely to understate their performance in MD&As compared to companies in other markets such as China and Taiwan.
Impact of the Diabetes Canada Guideline Dissemination Strategy on the Prescription of Vascular Protective Medications: A Retrospective Cohort Study, 2010–2015
Authors: Rigobon Alanna V. , Kalia Sumeet , Nichols Jennica , Aliarzadeh Babak , Greiver Michelle , Moineddin Rahim , Sullivan Frank , Yu Catherine 
Published: November 2018

OBJECTIVEThe 2013 Diabetes Canada guidelines launched targeted dissemination tools and a simple assessment for vascular protection. We aimed to 1) examine changes associated with the launch of the 2013 guidelines and additional dissemination efforts in the rates of vascular protective medications prescribed in primary care for older patients with diabetes and 2) examine differences in the rates of prescriptions of vascular protective medications by patient and provider characteristics.RESEARCH DESIGN AND METHODSThe study population included patients (≥40 years of age) from the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) with type 2 diabetes and at least one clinic visit from April 2010 to December 2015. An interrupted time series analysis was used to assess the proportion of eligible patients prescribed a statin, ACE inhibitor (ACEI)/angiotensin receptor blocker (ARB), or antiplatelet prescription in each quarter. Proton pump inhibitor (PPI) prescriptions were the reference control.RESULTSA dynamic cohort was used where participants were enrolled each quarter using a prespecified set of conditions (range 25,985–70,693 per quarter). There were no significant changes in statin (P = 0.43), ACEI/ARB (P = 0.42), antiplatelet (P = 0.39), or PPI (P = 0.16) prescriptions at baseline (guideline intervention). After guideline publication, there was a significant change in slope for statin (−0.52% per quarter, SE 0.15, P &lt; 0.05), ACEI/ARB (−0.38% per quarter, SE 0.13, P &lt; 0.05), and reference PPI (−0.18% per quarter, SE 0.05, P &lt; 0.05) prescriptions.CONCLUSIONSThere was a decrease in prescribing trends over time that was not specific to vascular protective medications. More effective knowledge translation strategies are needed to improve vascular protection in diabetes in order for patients to receive the most effective interventions.
Long-term Mortality After Kidney Transplantation in a Nationwide Cohort of Patients With Type 1 Diabetes in Finland
Authors: Ortiz Fernanda , Harjutsalo Valma , Helanterä Ilkka , Lempinen Marko , Forsblom Carol , Groop Per-Henrik 
Published: November 2018

OBJECTIVE
To examine time trends in mortality rates and causes of death in patients with type 1 diabetes and end-stage renal disease on dialysis and after kidney transplantation.

RESEARCH DESIGN AND METHODS
In a nationwide retrospective cohort analysis, all patients with type 1 diabetes in Finland who received a kidney transplant alone were compared with patients who remained on dialysis. The main outcome was patient survival after starting dialysis. The cohort was divided into dialysis, functioning kidney transplant, and dialysis after transplant loss. Causes of death were retrieved and standardized mortality ratios calculated.

RESULTS
We studied 2,383 patients. Patients survived a median of 15.9 years after a successful transplant, 11.2 years if transplant function was lost, and 2.9 years if they remained on chronic dialysis. Standardized mortality ratio decreased in all subgroups during the past four decades: from 2005 onwards, it was 3.9 in patients receiving a kidney transplant, 11.5 in patients with graft loss, and 32.5 in patients on dialysis. The most common cause of death in all patients was ischemic heart disease (45%) followed by infection (18%), which was more common in patients on dialysis.

CONCLUSIONS
Kidney transplantation is the treatment of choice for patients with type 1 diabetes and end-stage renal disease because it substantially reduces the excess death risk when compared with dialysis. Even when kidney graft function is lost, the excess death risk is still considerably lower. Although overall mortality has decreased over the years, premature death due to ischemic heart disease remains high.
Evaluasi 3D Texturing Process Pada Bentuk Dinding Bangunan Bersejarah Candi Cetho
Authors: Setiawan Dimas 
Published: November 2018

<p>Pemanfaatan teknologi dapat dimanfaatkan untuk membantu pemerintah dalam upaya pelestarian budaya, trend baru dalam melakukan proses rekonstruksi yang biasa dilakukan adalah dengan melakukan Pemodelan 3D dengan menggunakan teknik scan dan fotogrametri. Pemodelan menggunakan teknik <em>polygonal modeling</em> menghasilkan produk model 3D dari candi cetho, namun proses pemberian teksturnya perlu melewati beberapa uji coba sehingga mampu menghasilkan produk yang menyerupai aslinya. Pemodelan 3D candi cetho dengan <em>procedural texture</em> didapatkan prosentase Sebanyak 72 % Tidak mirip,20 % mirip, dan 6% sangat Tidak mirip sedangkan Untuk Model 3D candi cetho dengan <em>files textures</em> didapatkan prosentase Sebanyak 84 % mirip dan 16 % sangat mirip.</p>
Rancang Bangun Aplikasi Manajemen Event Berbasis SMS Gateway pada BKKBN Kabupaten Madiun
Authors: Purwaningsih Emis Safitri 
Published: November 2018

<em>BKKBN adalah salah satu instansi pelayanan pada bidang KB. Selama ini untuk promosi dilakukan dengan penyebaran poster dan dilakukan kunjungan ke setiap rumah dengan waktu tertentu. Namun, hal ini dirasa kurang efektif dan menyebabkan jumlah karyawan yang diperbantukan ke kecamatan menjadi lebih banyak. Oleh karena itu penulis merancang dan membangun Aplikasi Manajemen Event Berbasis SMS Gateway pada BKKBN Kabupaten Madiun. Penelitian ini bertujuan untuk mengetahui perancangan dan kelayakan Aplikasi Manajemen Event Berbasis SMS Gateway pada BKKBN Kabupaten Madiun. Penelitian dilakukan di BKKBN Kabupaten Madiun dengan jumlah karyawan yang bekerja di kantor berjumlah 20 karyawan. Metode penelitian yang digunakan adalah metode waterfall. Penelitian dilakukan dengan tahapan analisis kebutuhan, desain sistem, penulisan kode program, pengujian program dan penerapan program.Teknik analisa data yang digunakan untuk menguji kelayakan Aplikasi Manajemen Event Berbasis SMS Gateway dengan menggunakan lembar validitas, lembar angket respon dan lembar observasi. Prosentase yang dihasilkan pada lembar validitas 91% (sangat valid) dari koresponden sebanyak 4 ahli. Prosentase yang dihasilkan pada angket respon 96% (sangat praktis) dari koresponden sebanyak 12 staff. Kenaikan prosentase pada hasil observasi sebesar 63,33% yang artinya dengan adanya aplikasi maka efektivitas pekerjaan semakin tinggi. Dari ketiga teknik analisa tersebut disimpulkan bahwa Aplikasi Manajemen Event Berbasis SMS Gateway pada BKKBN Kabupaten Madiun layak digunakan</em>
Tunable Metal-Organic Frameworks Enable High Efficiency Cascaded Adsorption Heat Pumps
Authors: Rieth Adam , Wright Ashley M. , Rao Sameer , Kim Hyunho , LaPotin Alina , Wang Evelyn N. , Dinca Mircea 
Published: November 2018

Rising global standards of living coupled with the recent agreement to eliminatehydrofluorocarbon refrigerants are creating intense pressure to develop more sustainable climatecontrol systems. In this vein, the use of water as the refrigerant in adsorption heat pumps is highlyattractive, but such adsorption systems are constrained to large size and poor efficiency by thecharacteristics of currently employed water sorbents. Here we demonstrate control of the relativehumidity of water uptake by modulating the pore size in a family of isoreticular triazolate metalorganicframeworks. Using this method, we identify a pair of materials with stepped, nonoverlappingwater isotherms that can function in tandem to provide continuous cooling with arecord ideal coefficient of performance of 1.63. Additionally, when used in a single-stage heatpump, the microporous Ni2Cl2BBTA has the largest working capacity of any material capable ofgenerating a 25 °C difference between ambient and chiller output.
Pengukuran Kinerja Rantai Pasok Dengan Model Supply Chain Operations Reference (SCOR) dan Metode Perbandingan Berpasangan
Authors: Liputra David Try , Santoso Santoso , Susanto Nadya Ariella 
Published: November 2018

<p><em>The rapid development of the industrial world has resulted in increasingly tight competition among companies. This condition shows the importance of improving performance, not only in a company but also other parties in the related supply chain, in order to compete with other companies or supply chains. The good performance of a supply chain will certainly increase the customers satisfaction. Therefore, performance measurement needs to be carried out so that a supply chain can find out how well it currently performing is and keep improving it. This study will discuss about the application of the supply chain operations reference (SCOR) model and the pairwise comparison method for the supply chain performance measurement of a product packaging company</em> </p><p><strong><em>Keywords: supply chain, performance measurement, SCOR, </em></strong><strong><em>pairwise comparison</em></strong></p><strong><em><br /></em></strong>
To the readers of JPE
Authors: Thomson James 
Published: November 2018

Although still young, the Journal of Pollination Ecology has established itself as a successful and vital conduit for research results, methodological advances, and—to some extent—opinion pierces concerning the diverse field of pollination biology. In a sense, it has been too successful, because the founding Editor-in-Chief, Carolin Mayer, has decided that she needs assistance in handling the increased volume of submissions and associated tasks. After deliberating, the board members of JPE have opted to try a new arrangement. I have accepted their invitation to join the effort as Editor-in-Chief, while Carolin’s title will switch to Managing Editor. She will retain responsibility for the essential operation and production of the journal, while I will take on ultimate responsibility for evaluating submissions, finding reviewers, and establishing the content of the journal. Of course, I will depend heavily on the Associate Editors in this effort.