bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in Nanoparticle-based Delivery of Next Generation Peptide Nucleic Acids
Authors: Malik Shipra , Asmara Brenda , Moscato Zoe , Mukker Jatinder Kaur , Bahal Raman 
Published: January 2019

Background:Peptide nucleic acids (PNAs) belong to the next generation of synthetic nucleic acid analogues. Their high binding affinity and specificity towards the target DNA or RNA make them the reagent of choice for gene therapy-based applications.Objective:To review important gene therapy based applications of regular and chemically modified peptide nucleic acids in combination with nanotechnology.Method:Selective research of the literature.Results:Poor intracellular delivery of PNAs has been a significant challenge. Among several delivery strategies explored till date, nanotechnology-based strategies hold immense potential. Recent studies have shown that advances in nanotechnology can be used to broaden the range of therapeutic applications of PNAs. In this review, we discussed significant advances made in nanoparticle-based on PLGA polymer, silicon, oxidized carbon and graphene oxide for the delivery of PNAs.Conclusion:Nanoparticles delivered PNAs can be implied in diverse gene therapy based applications including gene editing as well as gene targeting (antisense) based strategies.
Comparative Efficacy of Chitosan, Pectin Based Mesalamine Colon Targeted Drug Delivery Systems on TNBS-induced IBD Model Rats
Authors: Newton Amaldoss M.J. , Lakshmanan Prabakaran 
Published: January 2019

Objective:
A number of natural polymer-based drug delivery systems targeting
the colon are reported for different applications. Most of the research is based on the class
of natural polymers such as polysaccharides. This study compares the anti-inflammatory
effect of different polysaccharide based tablets on IBD when a drug carrier is targeted to
the colon as matrix and coated systems.

Methods:
The TNBS induced IBD Wistar rats were used as a model for the study. The microscopic
and macroscopic parameters were studied in detail. Almost all the important IBD
parameters were reported in this work.

Results:
The results demonstrated that the polysaccharides are efficient in carrying the
drugs to the colon. Reduction in the level of ulcer index (UI), Myeloperoxidase (MPO),
and Malondialdehyde MDA, confirmed the inhibitory activity on the development of Reactive
oxygen species (ROS). The increased level of Tumor necrosis factor (TNFα) an expression
of colonic inducible nitric oxide synthase (iNOS) was lowered in treatments as
compared to TNBS control.

Conclusion:
The different polymer-based mesalamine (DPBM) confirmed the efficient anti-
inflammatory activity on IBD induced rats. The increased level of glutathione (GSH),
and superoxide dismutase (SOD) also confirmed the effective anti-inflammatory effect. A
significant decrease in the ulcer score and ulcer area was reported. The investigation revealed
that chitosan is superior to pectin in IBD treatment likewise polysaccharide-based
matrix systems are superior to the coated system.
Exploring the Antimicrobial Properties Against Human Pathogens and Mode of Action of Various Extracts from Fredolia aretioides, an Endemic Medicinal Plant of Morocco and Algeria
Authors: Bouchal Btissam , Errahhali Mounia Elidrissi , Errahhali Manal Elidrissi , Boulouiz Redouane , Ouarzane Meryem , Tajir Mariam , Matsunami Katsuyoshi , Bellaoui Mohammed 
Published: January 2019

Background:Developing new antimicrobial medicines is one of the strategic objectives of the global action plan adopted by the World Health Organization to tackle antimicrobial resistance.Objective:Considering the fact that natural products derived from medicinal plants are an important source for discovering new antimicrobial compounds, we investigated here the antimicrobial properties and the mode of action of various extracts from Fredolia aretioides, an endemic medicinal plant of Morocco and Algeria, and belonging to the Chenopodiaceae family.Methods:Various extracts from F. aretioides were prepared and evaluated for their antibacterial activity against six bacterial species, and their antifungal activity against five fungi species. Chemicalgenetic screens were performed using a collection of Saccharomyces cerevisiae viable haploid deletion mutants spanning diverse biological processes.Results:The diethyl ether extract of roots was found to be active against Citobacter freundii, with a MIC of 400 µg/ml. Hydro-methanol, methanol and residual extracts from aerial parts and roots were active against all five fungi species tested. Our results showed that residual extracts were the most effective against the fungi tested. Residual extract from aerial parts was more potent than the residual root extract, with IC50’s of 60 µg/ml and 440 µg/ml, respectively. Chemical-genetic analysis in S. cerevisiae revealed that residual extracts might affect fatty acid and sphingolipid biosynthesis.Conclusion:All these findings suggest that F. aretioides is a promising source for the isolation of novel antimicrobial agents with novel mechanisms of action against human pathogens.
Studies on the EC50 of Natural Monoterpenes as Fungal Inhibitors with Quantitative Structure-Activity Relationships (QSARs)
Authors: Badawy Mohamed E.I. , Rabea Entsar I. , Abdelgaleil Samir A.M. 
Published: January 2019

Background:Monoterpenes are the main constituents of the essential oils obtained from plants. These natural products offered wide spectra of biological activity and extensively tested against microbial pathogens and other agricultural pests.Methods:Antifungal activity of 10 monoterpenes, including two hydrocarbons (camphene and (S)- limonene) and eight oxygenated hydrocarbons ((R)-camphor, (R)-carvone, (S)-fenchone, geraniol, (R)-linalool, (+)-menthol, menthone, and thymol), was determined against fungi of Alternaria alternata, Botrytis cinerea, Botryodiplodia theobromae, Fusarium graminearum, Phoma exigua, Phytophthora infestans, and Sclerotinia sclerotiorum by the mycelia radial growth technique. Subsequently, Quantitative Structure-Activity Relationship (QSAR) analysis using different molecular descriptors with multiple regression analysis based on systematic search and LOOCV technique was performed. Moreover, pharmacophore modelling was carried out using LigandScout software to evaluate the common features essential for the activity and the hypothetical geometries adopted by these ligands in their most active forms.Results:The results showed that the antifungal activities were high, but depended on the chemical structure and the type of microorganism. Thymol showed the highest effect against all fungi tested with respective EC50 in the range of 10-86 mg/L. The QSAR study proved that the molecular descriptors HBA, MR, Pz, tPSA, and Vp were correlated positively with the biological activity in all of the best models with a correlation coefficient (r) ≥ 0.98 and cross-validated values (Q2) ≥ 0.77.Conclusion:The results of this work offer the opportunity to choose monoterpenes with preferential antimicrobial activity against a wide range of plant pathogens.
Intuitionistic Fuzzy Shapley-TOPSIS Method for Multi-Criteria Decision Making Problems Based on Information Measures
Authors: Kumari Reetu , Mishra Arunodaya R. , Sharma Deelip K. 
Published: January 2019

Aims & Background:
Cloud Computing (CC) offers unique scalable and all time available services
to the user. As service provision is an important part of the Cloud computing concept, the proper
choice of the desired service is of most relevance according to the users’ needs. Various associations like as
Microsoft and Facebook have revealed momentous investments in CC and currently offer services with top
levels of reliability. The well-organized and precise evaluation of cloud-based communication network is an
essential step in assurance both the business constancy and the continuous open services. However, with a
vast diversity in the cloud services, selection of a suitable cloud service is a very challenging task for a user
under an unpredictable environment. Due to the multidimensional criteria of Quality of Service (QoS), cloud
service selection problems are treated as Multiple Criteria Decision-Making (MCDM) problem.

Objectives & Methodology:
In present paper, a Multi-Criteria Decision Making (MCDM) method named as
Shapley-TOPSIS method, which is extension of classical TOPSIS method for cloud service selection is developed.
Thereafter, new divergence measures for IFSs with multiple parameters are studied. The interesting
properties among the developed divergence and entropy measures have also been derived. Then, the criterion
weights are ascertained by Shapley function via entropy and fuzzy measure approach. Next, Shapleydivergence
measures are applied to calculate closeness coefficient of alternative. Finally, a problem of cloud
service selection is demonstrated to show the applicability of new method and also compared with some existing
method.

Results & Conclusion:
A decision making problem of cloud computing service provider has been considered
for signifying the developed proposed intuitionistic fuzzy Shapley TOPSIS method and finishes with
the outcomes coincide with the already developed methods which confirms the solidity of the developed
method. For future, we plan to apply the proposed approach with different multi-criteria decision making
problems. Also, we can extend proposed approach with other uncertain environment by using other decision
making methods.
Las Hydrangeas trepadoras (Hydrangeaceae) de México, incluyendo la descripción de seis nuevas especies en peligro (crítico)
Authors: Samain Marie-Stéphanie , Hernández Najarro Francisco , Martínez Salas Esteban Manuel 
Published: January 2019

Antecedentes y Objetivos: El género Hydrangea consta de aproximadamente 200 taxones en Asia y América. Mientras que las especies arbustivas de Asia y los EUA, así como los más de 1000 híbridos y cultivares derivados de estos, son muy conocidos por su valor ornamental, las especies neotropicales son mucho menos apreciadas. Hydrangea sección Cornidia, con 13 taxones aceptados, se distribuye desde México hasta Chile y Argentina, con una especie en el sureste de Asia. Sus representantes son lianas trepadoras que pueden crecer hasta 60 m de altura en el dosel de árboles de bosques templados a selvas (sub)tropicales. Extenso trabajo de campo a lo largo de su área de distribución y estudio de especímenes de herbario ha resultado en el descubrimiento de nuevos taxones. Presentamos una revisión de las diez especies mexicanas actualmente conocidas.Métodos: Se llevó a cabo trabajo de campo en el noroeste, centro y sureste de México, incluida la exploración en áreas donde el género no se había recolectado anteriormente. Se llevaron a cabo estudios morfológicos y arquitectónicos detallados, basados en plantas vivas en su hábitat natural, así como en muestras secas de nuestras colecciones y el material de herbario disponible.Resultados clave: Se describen seis especies nuevas para la ciencia, incluyendo una clave de identificación para las nativas y una ampliamente cultivada, ilustraciones y mapas de distribución. Se presentan descripciones enmendadas para dos especies descritas anteriormente, por lo que todas las Hydrangeas mexicanas conocidas actualmente cuentan con una descripción morfológica detallada.Conclusiones: El género Hydrangea ejemplifica la falta de actividades de recolección botánica específicas de taxones en México. El descubrimiento de estas nuevas especies es aún más sorprendente teniendo en cuenta el tamaño considerable de estas plantas. Todas las especies mexicanas están amenazadas, principalmente debido a la deforestación y cambios en el uso del suelo.
Facing real-life with direct oral anticoagulants in patients with nonvalvular atrial fibrillation: outcomes from the first observational and prospective study in a Spanish population
Authors: Cerdá María , Cerezo-Manchado Juan J , Johansson Erik , Martínez Fernanda , Fernández Mariana , Varela Ana , Rodríguez Saray , Bosch Francesc , Santamaría Amparo 
Published: January 2019

Aim:
To analyze the effectiveness and safety of direct oral anticoagulants (DOACs) in atrial fibrillation (AF) patients attended in clinical practice.
Methods:
Observational and prospective study of AF patients that started treatment with DOACs.
Results:
1443 patients (age 77.2 ± 9.7 years, CHA
2
DS
2
-VASc = 4.1 ± 1.5) were included. 46.0% were taking rivaroxaban, 24.4% dabigatran, 22.5% apixaban and 7.1% edoxaban. Patients taking dabigatran were younger, had lower CHA
2
DS
2
-VASc and lesser renal insufficiency. Patients taking apixaban had higher CHA
2
DS
2
-VASc and more renal insufficiency. Rates of stroke/major bleeding/intracranial bleeding were 0.7/1.3/0.2 events/100 patient-years, respectively.
Conclusion:
This was the first prospective study that analyzed the use of all DOACs in AF patients in Spain, showing a good profile in terms of safety and effectiveness in accordance with pivotal studies.
La economía de John Kenneth Galbraith: Una visión personal en tres partes
Authors: Galbraith James K. 
Published: January 2019

<p class="Standard" align="right"> </p><p class="Standard"> </p><p class="Standard">El objetivo es hacer una lectura histórica, biográfica y analítica de las principales contribuciones de John K Galbraith, un economista de su tiempo. Se indaga acerca de las más importantes influencias que su obra fue mostrado, así como de las mayores contribuciones que su obra ha representado para la construcción de modelos de desarrollo capitalista más estables. Se sostiene que aunque no pueda situarse un espacio académico de desarrollo del pensamiento de Galbraith, ha sido muy potente su influencia en el desarrollo de países como Alemania, Japón o China. Aunque dejo de serlo en los Estados Unidos principalmente debido al ascenso del poder oligárquico financiero desde los años setenta. </p><p class="Standard">JEI: B25; B31; B52; E31</p><div><br clear="all" /><div><p> </p></div></div>
MOLECULAR-EPIDEMIOLOGICAL CHARACTERISTICS OF HIV1 VARIANTS CIRCULATING IN THE JEWISH AUTONOMOUS REGION TERRITORY
Authors: Kotova V. O. , Trotsenko O. E. , Balakhontseva L. A. , Bazykina E. A. , Yanovich O. A. , Schikanov Yu. V. , Pavlova M. N. , Shmakova T. I. 
Published: January 2019

Objective: to perform a molecular-epidemiological analysis of HIV-1 variants circulating in the Jewish autonomous region territory. Materials and methods. The research included 58 patients with HIV-infection. Amplified pol-gene fragments were used as a template to detect drug resistance mutations by Sanger sequencing (AmpliSens® HIV-Resist-Seq). Pol-gene is coding protease and a part of reverse transcriptase of HIV-1. Phylogenetic analysis was performed using MEGA version 6.0 program. Results: the research revealed an insignificant prevalence of HIV-1 СRF63_02A1 recombinant form. It was registered in 25 patients (44,6%). Sub-subtype A6 was identified in 23 HIV-positive people (41,1%). Subtype B was revealed in 6 cases (10,7%), subtype С — in two cases (3,6%). Primary drug resistance mutations were identified in 9 patients that were undergoing antiretroviral treatment. This dictates the necessity to change the treatment regimen in the specified patients. The prevalence index of drug resistance mutations in naïve patients equaled to 3,8%.
On the Development of Creep Laws for Rubber in the Parallel Rheological Framework
Authors: Sagar Gautam , Zheng Dong , Suwannachit Anuwat , Brinkmeier Maik , Fietz Kristin , Hahn Carsten 
Published: January 2019

ABSTRACT
It is widely known that filler-reinforced rubber material in tires shows a very complicated material behavior when subjected to cyclic loadings. One of the most interesting effects for rolling tires is the nonlinear rate-dependent behavior, which is implicitly linked to the amplitude dependency of dynamic stiffness (Payne effect) at a given frequency and temperature. This effect, however, cannot be described by a conventional linear viscoelastic constitutive law, e.g., the Prony series model. Several nonlinear viscoelastic material models have been proposed in the last decades. Among others, Lapczyk et al. (Lapczyk, I., Hurtado, J. A., and Govindarajan, S. M., “A Parallel Rheological Framework for Modeling Elastomers and Polymers,” 182nd Technical Meeting of the Rubber Division of the American Chemical Society, Cincinnati, Ohio, October 2012) recently proposed a quite general framework for the class of nonlinear viscoelasticity, called parallel rheological framework (PRF), which is followed by Abaqus. The model has an open option for different types of viscoelastic creep laws. In spite of the very attractive nonlinear rate-dependency, the identification of material parameters becomes a very challenging task, especially when a wide frequency and amplitude range is of interest.
This contribution points out that the creep law is numerically sound if it can be degenerated to the linear viscoelastic model at a very small strain amplitude, which also significantly simplifies model calibration. More precisely, the ratio between viscoelastic stress and strain rate has to converge to a certain value, i.e., the viscosity in a linear viscoelastic case. The creep laws implemented in Abaqus are discussed in detail here, with a focus on their fitting capability. The conclusion of the investigation consequently gives us a guideline to develop a new creep law in PRF. Here, one creep law from Abaqus that meets the requirements of our guideline has been selected. A fairly good fit of the model is shown by the comparison of the simulated complex modulus in a wide frequency and amplitude range with experimental results.
O Ensino da Adição e Subtração de Arcos Trigonométricos, através da Música: Um Relato de Prática.
Authors: Teodoro Renata Aparecida Pereira 
Published: January 2019

O relato de prática, trata de uma experiência da inclusão da música para ensinar adição e subtração de arcos, como alunos da 2º Série do Ensino Médio da Escola Estadual Maurílio Albanese Novais de Ipatinga, Minas Gerais em 2015.
Através da prática, os alunos conseguiram assimilar o conteúdo de forma dinâmica e criativa, contribuindo positivamente para aprendizagem do mesmo.
Dysfunction of mitochondria as the basis of Parkinson’s disease
Authors: Popis Małgorzata 
Published: January 2019

Abstract
Parkinson's disease is the second most common neurodegenerative disease, affecting about 0,15-0,3% of the world's population. Its characteristic feature is a loss of dopaminergic neurons in the substantia nigra. PD leads to dopamine deficiency and formation of intracellular inclusions called Lewy bodies, whose main ingredient is α-synuclein. Other types of nervous system cells are also affected by changes associated with that disease. The underlying molecular pathogenesis involves multiple pathways and mechanisms: mitochondrial function, oxidative stress, genetic factors, α-synuclein proteostasis, mitochondrial dynamic impairment, and disorders of the mitophagy process. This review summarizes the factors affecting the functioning of the mitochondria and their connection to the development of Parkinson's disease.
Cinnamyl-Imine-Chitosan Hydrogels. Morphology Control
Authors: Craciun Anda M. 
Published: January 2019

Abstract
The study deals with the exploration of the possibilities to control the morphology of cinnamyl-imine-chitosan hydrogels in view of their bio-application. Three series of hydrogels were synthetized from chitosan of three different molecular weights and cinnamaldehyde, varying the molar ratio between the amine groups on chitosan and aldehyde functional groups. The hydrogel morphology has been monitored by scanning electron microscopy. The variation of the hydrogel morphology as a function of chitosan molecular weight, crosslinking degree, and incubation conditions has been monitored. It was concluded that there are multiple possibilities of tuning the morphology of these hydrogels in function of the targeted application.
Electroplastic Deformation by Twinningmetals
Authors: Savenko Vladimir V. 
Published: January 2019

Abstract
The article deals with theoretical and experimental approaches to electroplastic deformation caused by twinning of metals. The author specifies physical fundamentals of Kinetics regarding the development of twinning caused by the excitation of electronic subsystem of metals. Physical models of new channels for the realization of twinning aroused under conditions of electroplasticity have been discussed. Mechanisms of plasticized influence of a surface electric charge have been defined as well as the contribution of a dynamic pinch-effect in the elastic plastic deformation of metals with the participation of the intrinsic magnetic field of the current. The dynamic pinch effect creates ultrasonic vibration of the lattice system while Kinetics changes and plastic deformation are stimulated increasing the amplitude of the oscillations of rectilinear dislocations and the periodic change in the position of the dislocation loops with an increase in the probability of detachment of dislocations from the stoppers. When deformed above the yield point and due to the pinch effect the intrinsic magnetic field of the current diffuses into the crystal where the diffusion rate depends both on the conductivity of the metal and on the frequency of the current. It is necessary to take into account the physical conditions for the creation of ponderomotive effects in relation to specific technically important materials for the practical use of electroplastic deformation technology, especially when processing metals with pressure.
Development of Intercultural Competence during Pedagogical Practice of Ukrainian Students in Vocational Schools in Slovakia
Authors: Ryabchikova Kateryna 
Published: January 2019

Abstract

Introduction:
In the presented paper, the role of practical training in the formation of intercultural competencies is considered in terms of Dublin descriptors on the basis of educational intercultural practice.

Methods:
For the purposes of the study, a multi-stage model of intercultural practice was developed. The method of comparative analysis showed the correspondence of the model to the main descriptors. The study is based on the results of intercultural practice of Ukrainian students in vocational schools in Slovakia.

Results:
It has been shown that the four levels of practice in the form of short-term introductory intercultural practice, ethno-cultural educational practice, scientific and pedagogical communication practice abroad, as well as long-term intercultural training correspond to the Dublin competence descriptors in the form of knowledge, skills, communication, autonomy and responsibility.

Discussion:
The results of the research show the directions in the formation of intercultural competencies of students. Close cultures such as the Ukrainian and the Slovak can be a launching pad for building deeper competencies. The pedagogical practice of Slovak and Ukrainian students develops the intercultural competencies of both the trainees and the students.

Limitations:
The study was conducted in a limited number of educational institutions in Ukraine and Slovakia. It is expected to increase their number on the principles of reciprocity in order to develop intercultural competencies in the students of the two countries.

Conclusions:
The model is practically implemented in the process of the teaching practice of Ukrainian students in selected schools in Slovakia. An increase in the level of intercultural competencies was observed both in the Ukrainian students and in the students of Slovak schools.