bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fast and sensitive protein sequence homology searches using hierarchical cluster BLAST
Authors: Nasko Daniel J. , Wommack K. Eric , Ferrell Barbra D. , Polson Shawn W. 
Published: September 2018

AbstractThe throughput of DNA sequencing continues to increase, allowing researchers to analyze genomes of interest at greater depths. An unintended consequence of this data deluge is the increased cost of analyzing these datasets. As a result, genome and metagenome annotation pipelines are left with a few options: (i) search against smaller reference databases, (ii) use faster, but less sensitive, algorithms to assess sequence similarities, or (iii) invest in computing hardware specifically designed to improve BLAST searches such as GPGPU systems and/or large CPU-rich clusters.We present a pipeline that improves the speed of amino acid sequence homology searches with a minimal decrease in sensitivity and specificity by searching against hierarchical clusters. Briefly, the pipeline requires two homology searches: the first search is against a clustered version of the database and the second is against sequences belonging to clusters with a hit from the first search. We tested this method using two assembled viral metagenomes and three databases (Swiss-Prot, Metagenomes Online, and UniRef100). Hierarchical cluster homology searching proved to be 12-times faster than BLASTp and produced alignments that were nearly identical to BLASTp (precision=0.99; recall=0.97). This approach is ideal when searching large collections of sequences against large databases.
Spatial ecology of Paraguay’s last remaining Atlantic forest jaguars (Panthera onca): implications for their long-term survival
Authors: McBride Roy T , Thompson Jeffrey J 
Published: September 2018

AbstractUsing GPS telemetry we quantified space use and movements of jaguar (Panthera onca) in remnant populations in the Paraguayan Atlantic forest within a comparative context with populations in the Argentine and Brazilian Atlantic forest. Mean estimated home range size was 160 km2; estimated to be nearly equal to jaguars in the Morro do Diabo State Park in Brazil but jaguars in other populations in Argentina and Brazil had a 73% (Iguazú/Iguaçu national park complex) and 96% (Ivinhema State Park) probability of having larger home ranges. We found no relationship between home range size or movements and human population or the Human Footprint Index, while 75% of locations from all individuals were in protected areas. Our data and analysis highlight the dependence of Atlantic forest jaguars on protected areas, an avoidance of the landscape matrix and an extreme isolation of the remaining Paraguayan Atlantic forest jaguars.
Setting the Occasion for Incentive Motivation: Implications for Addiction
Authors: Fraser Kurt M. , Janak Patricia H. 
Published: September 2018

AbstractThe context in which reward-paired cues are encountered sets the occasion for appropriate reward-seeking but may also spur inappropriate behaviors such as the renewal of drug-seeking. The psychological processes underlying occasion setting remain unclear as contexts are diffuse and difficult to isolate from other stimuli. To overcome this, we modeled a context as a phasic and discrete event – an occasion setter – which allowed for control over its presentation and influence on cue-driven reward-seeking. This allowed us to directly assess how occasion setters, like contexts, regulate the predictive and motivational significance of Pavlovian cues. Male rats (n=50) were trained in a Pavlovian paradigm where the presentation of an ambiguous conditioned stimulus was reinforced only if preceded by an occasion setting cue. We assessed the motivational value of the occasion setter and conditioned stimulus alone or in combination using conditioned reinforcement. Rats showed enhanced conditioned approach to the reward port during the reward-adjacent conditioned stimulus when it was preceded by the occasion setter. When allowed the opportunity, rats responded more to obtain presentations of the conditioned stimulus in combination with the occasion setter than the conditioned stimulus alone. Critically, rats also worked to obtain presentations of the occasion setter alone more than the conditioned stimulus, and this was resistant to manipulations of the value of the occasion setter. We conclude that occasion setting can act via incentive motivational mechanisms and that, apart from resolving predictive information about ambiguous reward-paired cues, occasion setters themselves generate states of appetitive motivation that can facilitate reward-seeking.
Rapid parameter identification and control of an induction machine
Authors: Nell Martin Marco , von Pfingsten Georg , Hameyer Kay 
Published: September 2018

Purpose
Traction applications, e.g. the IMs are mainly operated by field-oriented control (FOC). This control technique requires an accurate knowledge of the machine’s parameters, such as the main inductance, the leakage inductances and the stator and rotor resistance. The accuracy of the parameters influences the precision of the calculated rotor flux and the rotor flux angle and the decoupling of the machine’s equations into the direct and quadrature coordinate system (dq-components). Furthermore, the parameters are used to configure the controllers of the FOC system and therefore influence the dynamic behavior and stability of the control.

Design/methodology/approach
In this paper, three different methods to calculate the machine’s parameters, in an automated and rapid procedure with minimal measuring expenditure, are analyzed and compared. Moreover, a method to configure a control that reduces the overall Ohmic losses of the machine in every torque speed operation point is presented. The machine control is configured only with the identified machine parameter.

Findings
Simulations and test bench measurements show that the evolutionary strategy is able to identify the electrical parameters of the machine in less time and with low error. Moreover, the controller is able to control the torque of the machine with a deviation of less than 2 per cent.

Originality/value
The most significant contribution of the research is the potential to identify the machine parameter of an induction motor and to configure an accurate control with these parameters.
Emirates Dates: a case of growth strategy dilemma
Authors: Zamberi Ahmad Syed , Rahim Abu Bakar Abdul 
Published: September 2018

Subject area
Strategic marketing, Business strategy, Product diversification strategy and/or Market entry strategy.

Study level/applicability
This case is useful for undergraduate and postgraduate students who are pursuing majors in marketing, business management and/or strategic management.

Case overview
The Emirates Dates Factory commenced operations in 1989 in Ras Al Khaimah, United Arab Emirates (UAE), as a 100 per cent equity held by Mr Abdullah Al Shamsi. Over time, it has become one of the best and renowned factory for date production and processing. Emirates Dates derives its strength from its own plantations in Ras Al Khaimah and Al Ain, as well as from a wide variety of date products that it develops, including date syrup, dates in different packing and stuffed dates. The company seeks to be the leader of dates production and processing in terms of sales. However, the management is facing issues pertaining to determining the area of growth that it should pursue. This case study illustrates the growth options that Emirates Dates could pursue along with its opportunities and challenges that the firm faces.

Expected learning outcomes
This case study expose student to Ansoff growth matrix in general and the application of the market penetration strategy in specific. Accordingly, the case illustrates how one could develop other growth strategies to improve its revenues through product diversification and/or market development.

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 11: Strategy.
Quality higher education drives employability in the Middle East
Authors: Nauffal Diane , Skulte-Ouaiss Jennifer 
Published: September 2018

PurposeThe purpose of this paper is to analyse and explain the high rates of employability of one group of Middle East youth by focussing on liberal arts and soft skills education as an integral part of quality higher education.Design/methodology/approachThis paper employs the survey research method using questionnaires, focus groups and interviews to understand the labour market dynamics in Lebanon and explore factors that correlate positively with gainful employment with a special focus on the graduates of an institution that emphasises the liberal arts and soft skills training.FindingsThe paper finds that quality higher education – particularly with a focus on soft skills and internships – boosts the potential of graduates to secure their first jobs after graduation.Research limitations/implicationsReliable data on higher education, employability and youth are scarce in Lebanon and the region. The paper is based on one labour market study in Lebanon while seeking to extrapolate to Lebanese youth as a whole as well as reflect on employability and youth in the Middle East region.Practical implicationsThe paper demonstrates support for improving quality in higher education as well as making soft skills training and the liberal arts critical components for increased employability of youth in Lebanon and the Middle East.Originality/valueThe paper is innovative in its reliance on primary data from a labour market survey as such data are scarce in Lebanon. In addition, advocacy for soft skills training and the liberal arts in the midst of focus on science, technology, engineering and mathematics and other professional education at the university level is rare in the Middle East.
The increased international propensity of serial entrepreneurs demonstrating ambidextrous strategic agility
Authors: Vaillant Yancy , Lafuente Esteban 
Published: September 2018

PurposeThe purpose of this paper is to analyze whether business owners that simultaneously demonstrate past entrepreneurial experience and process agility have greater export propensity levels.Design/methodology/approachThe proposed hypotheses are tested using binary choice models relating past entrepreneurial experience and reported process agility on a unique sample of 246 Catalan business owners for the year 2010.FindingsConsistent with the theoretical arguments on the relevance of generative-based cognitive agility, the results of this paper reveal that serial entrepreneurs demonstrate a greater export propensity. Additionally, the authors found that serial entrepreneurs who also demonstrate process agility show superior export propensity levels, compared to the group of business owners outside this ambidextrous group (first-time business owners without process agility).Research limitations/implicationsThe findings of this study indicate that traits characterizing international marketing agility, decisional speed and accuracy are also linked with greater export propensity levels. The added export market expansion resulting from the opportunity responsiveness of serial entrepreneurs is found to be amplified by the accuracy of internal adaptation capabilities of process agility.Practical implicationsTherefore, the promotion of ambidextrous strategic agility coming from the complementarities between the benefits of entrepreneurial experience and adaptive process abilities is essential for increasing businesses’ internationalization.Originality/valueThe paper contributes to the literature by further exploring the influence of different sources of agility on the internationalization of entrepreneurial ventures and opens a link between entrepreneurs prone toward export market expansion and international marketing agility.
The European deposit insurance game plan
Authors: Kiriazidis Theo 
Published: September 2018

Purpose
This paper aims to analyze the development of European Deposit Insurance (DI) and assess the recent development at the EU level to establish a European Deposit Insurance Scheme (EDIS) in the context of a more integrated financial framework: the Banking Union (BU).

Design/methodology/approach
The author uses literature review and empirical evidence to analyze the dynamic interaction among European governments in an effort to attract aggressive deposits with severe repercussion for financial stability.

Findings
The paper argues that a liquidity providing EDIS would render regulatory subsidy and rent-seeking behavior persisting by allowing national policies to be pursued with considerable discretionary power and in the context of increasing competition for deposits. This would run contrary to the BU objectives and constitute a major failure of the program.

Practical implications
The findings of the study can be helpful in understanding the DI policies pursued by European governments and their implications.

Originality/value
To the best of the authors’ knowledge, this is the first study that examines the interactions among European governments in pursuing DI policies and assesses the implications of EDIS.
The SEC Speaks 2018: the US Securities and Exchange Commission’s current priorities and conference overview
Authors: Russelo Gerald J. , Cohen Stephen L. , Sanchez Jose F. 
Published: September 2018

Purpose
This paper aims to highlight certain comments made by US Securities and Exchange Commission (SEC) officials, which may provide insight into compliance and enforcement issues that may be important for market participants, including broker-dealers, investment advisors and reporting companies, in the future.

Design/methodology/approach
This paper explains comments made by SEC officials and highlights potential regulatory issues based on past experiences of attorneys within the firm, past comments made by the SEC and Financial Industry Regulatory Authority and past regulatory exam results.

Findings
This paper summarizes remarks from the recent SEC Speaks 2018 Conference conducted by SEC officials related to the Commission’s regulatory and enforcement priorities. Issuers, brokers, advisors and other financial organizations should familiarize themselves with the themes and guidance discussed at the Conference to prepare for regulatory compliance challenges in the upcoming year.

Originality/value
Practical guidance from experienced securities and financial services lawyers.
Social capital, power, school-based decision making, and the teaching assignment process
Authors: Lieberman Daina S. , Clayton Jennifer K. 
Published: September 2018

Purpose
The purpose of this paper is to investigate power and its influence on the teaching assignment process and school-based decision making.

Design/methodology/approach
Qualitative interpretive design and thematic analysis were used. Semi-structured interviews were conducted with teachers and administrators.

Findings
Both teachers and administrators discussed power and social capital as components of the teaching assignment process. Teachers viewed the origins of their social capital differently than administrators and felt social capital was evident in school-based decision making and the teaching assignment process.

Research limitations/implications
Participants were demographically rather homogeneous. Further studies with a diverse sample could examine race and gender as factors in the teaching assignment process.

Practical implications
This study demonstrates a need for administrators to examine how they consider social capital when distributing teaching assignments and involving teachers in school-based decision making. Administrators’ actions may result in teacher tracking, disadvantaging marginalized and at-risk student populations.

Social implications
There is a clear disconnect between administrator and teacher understanding of the purpose and practice of teaching assignment distribution. Administrators were unaware of their own power, how they wielded it, and the effect it had on teachers.

Originality/value
Few studies have examined teacher–administrator power relations or the teaching assignment process at the secondary level. This study connects the teaching assignment process to social capital and power.
Knowledge sharing and unethical pro-organizational behavior in a Mexican organization
Authors: Belausteguigoitia Rius Imanol , De Clercq Dirk 
Published: September 2018

PurposeThis paper aims to investigate the relationship of knowledge sharing with unethical pro-organizational behavior (UPB) and the potential augmenting effects of two factors: employees’ dispositional resistance to change and perceptions of organizational politics.Design/methodology/approachQuantitative data come from employees in a Mexican manufacturing organization. The hypotheses tests use hierarchical regression analysis.FindingsKnowledge sharing increases the risk that employees engage in UPB. This effect is most salient when employees tend to resist organizational change or believe the organizational climate is highly political.Practical implicationsOrganizations should discourage UPB with their ranks, and to do so, they must realize that employees’ likelihood to engage in it may be enhanced by their access to peer knowledge. Employees with such access may feel more confident that they can protect their organization against external scrutiny through such unethical means. This process can be activated by both personal and organizational factors that make UPB appear more desirable.Originality/valueThis study contributes to organizational research by providing a deeper understanding of the risk that employees will engage in UPB, according to the extent of their knowledge sharing. It also explicates when knowledge sharing might have the greatest impact, both for good and for ill.
From intention to entrepreneurial action
Authors: Oliveira António , Rua Orlando Lima 
Published: September 2018

Purpose
This paper aims to contribute to the explanatory debate of the entrepreneurial intention-action gap that results from the interposition of normative-regulatory, sociocultural and economic-financial barriers facing potential and intending entrepreneurs.

Design/methodology/approach
Grounded on post-positivist position, the authors propose a quantitative approach, surveying 569 potential and intending entrepreneurs from a longitudinal and stratified sample of 22 years.

Findings
The economic-financial barrier is the most important, followed by the sociocultural except in the period in which access to banking financial support is facilitated, where the order is reversed. The impact of the normative-regulatory barrier is statistically relevant, but irrelevant on the magnitude. The results also allow us to conclude that a lower development of the project accentuates the entrepreneurial intention-action gap and, finally, support the existence of a medium/long-term temporal relation between entrepreneurial intention and entrepreneurial action.

Research limitations/implications
From an empirical standpoint, the sample was limited to potential and pretending entrepreneurs from one national institution and one country. This limits the scope of generalization. Further studies in multiple contexts should be undertaken.

Practical implications
The study points to contradictory results with the Global Entrepreneurship Monitor – Portuguese Reports, which, if confirmed, require the reformulation of Portuguese national policies in the promotion and development of entrepreneurial activities.

Originality/value
The study is novel by providing new insights about entrepreneurship and the entrepreneurial intention-action gap.
Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2
Authors: Smith Andrew H. , Ovesen Peter L. , Skeldal Sune , Yeo Seungeun , Jensen Kevin P. , Olsen Ditte , Diazgranados Nancy , Zhao Hongyu , Farrer Lindsay A. , Goldman David , Glerup Simon , Kranzler Henry R. , Nykjær Anders , Gelernter Joel 
Published: September 2018

BackgroundEfforts to promote the cessation of harmful alcohol use are hindered by the affective and physiological components of alcohol withdrawal (AW), which can include life‐threatening seizures. Although previous studies of AW and relapse have highlighted the detrimental role of stress, little is known about genetic risk factors.MethodsWe conducted a genome‐wide association study of AW symptom count in uniformly assessed subjects with histories of serious AW, followed by additional genotyping in independent AW subjects.ResultsThe top association signal for AW severity was in sortilin family neurotrophin receptor gene SORCS2 on chromosome 4 (European American meta‐analysis n = 1,478, p = 4.3 × 10−9). There were no genome‐wide significant findings in African Americans (n = 1,231). Bioinformatic analyses were conducted using publicly available high‐throughput transcriptomic and epigenomic data sets, showing that in humans SORCS2 is most highly expressed in the nervous system. The identified SORCS2 risk haplotype is predicted to disrupt a stress hormone‐modulated regulatory element that has tissue‐specific activity in human hippocampus. We used human neural lineage cells to demonstrate in vitro a causal relationship between stress hormone levels and SORCS2 expression, and show that SORCS2 levels in culture are increased upon ethanol exposure and withdrawal.ConclusionsTaken together, these findings indicate that the pathophysiology of withdrawal may involve the effects of stress hormones on neurotrophic factor signaling. Further investigation of these pathways could produce new approaches to managing the aversive consequences of abrupt alcohol cessation.
Cash holdings, costly financing and theqtheory of returns
Authors: Galpin Neal 
Published: September 2018

AbstractI add cash holdings into an investment‐based model of stock returns. I motivate cash holdings via costly outside financing. The model shows a relation between stock returns and cash holdings and provides a structural foundation for estimating the value of cash holdings from regressions. I estimate the model at the firm level—a task notoriously difficult forqtheoretic models. Adding cash into the model substantially improves model fit on average, and accounting for costly investment and financing help improve fit across firms.
Challenges in managing parental expectations in paediatric care
Authors: du Pré Pascale , Brierley Joe 
Published: September 2018

AbstractGiven the recent number of controversial cases featured in the media, it is timely to consider the management of parental expectations in paediatric care. What is sadly overlooked in the controversy is the usual excellent working relationship formed by treating child health professionals, parents (those with parental responsibility) and children themselves in tackling really tough situations. We are able to do more and more to tackle previously deadly diseases, and yet the burden of our treatments is undeniably higher. At the same time, social changes and ready access to information have led to a necessary reduction in medical paternalism, and more empowered and knowledgeable patients. We review how things have become very challenging in this arena in the UK over the last decades, and consider the issues surrounding disagreements and conflict. On the background of population shifts, religious diversity and populism, parental expectations now vary dramatically given the same situation. The challenge is still met by communicating, listening with empathy but finally by adhering to the basic tenet of Article 3 of the UN Convention of the Rights of the Child – ‘The best interests of children must be the primary concern in making decisions that may affect them.’