bluuebunny/crossref_metadata_2025_split huggingface dataset:
MASTOCITOMA CUTÂNEO EM CÃES E GATOS
Authors: Tremante Mario Augusto 
Published: November 2024

O mastocitoma é um tumor mesenquimal redondo que acomete mastócitos em tecido cutâneo, representa de 7 a 21% de todos os tumores de pele em cães e cerca de 11 a 27% dos tumores malignos em cães. As raças mais acometidas são Boxer, Boston Terrier e Bulldog Inglês, além do Labrador, Golden Retriever e Shar Pei. Pode ocorrer um único nódulo de comportamento benígno a vários nódulos de comportamento malígno na derme e no tecido subcutâneo, mais pode ocorrer também em conjuntiva, glândula salivar, nasofaringe, laringe, cavidade oral, trato gastrointestinal e coluna. Nos gatos, os mais predispostos são os da raça siamês, machos e jovens e não ocorre predileção por idade. Pode ocorrer como uma massa elevada e firme, avermelhada ou não, com bordo assemelhando-se a uma borbulha e o centro amarelado, ou ainda como uma massa mole, pouco definida que geralmente possui pelos, e raramente é ulcerada ou avermelhada, as suas margens microscópicas estendem-se bastante para além do palpável à superfície. O diagnóstico é feito por citologia aspirativa com agulha fina e avaliação histológica para determinar o grau de malignidade, sendo a melhor forma de graduação, a classificação em baixo e alto grau.Nos felinos o diagnóstico é feito por citologia aspirativa com agulha fina. O tratamento para o mastocitoma em cães, vai depender da avaliação das condições físicas do paciente, além de fatores clínicos, classificação histológica e graduação do tumor. O tratamento mais indicado é a cirurgia, com margem de segurança de 3 cm, e também a radioterapia, e quimioterapia indicada para mastocitomas de alto grau e pode ser empregada com o objetivo de cito-redução ou como adjuvante à cirurgia ou associação dos três. Estudos recentes citam ainda inibidores da tirosina-quinase, eletroquimioterapia, terapêutica fotodinâmica. Em felinos o tratamento indicado é cirúrgico. O prognóstico vai depender da localização, número de tumor e presença de ulceração. Objetivou-se com este trabalho, uma revisão de literatura que trata do mastocitoma cutâneo canino e felino, abordando aspectos de incidência, etiologia, apresentação clínica, estadiamento clínico, diagnóstico, modalidades de tratamento e prognósticos.
TRATAMENTO DE FERIDA EM MEMBRO EQUINO COM BARBATIMÃO: RELATO DE CASO
Authors: Jesus Guilherme Rosales De , Yasuoka Melina 
Published: November 2024

O presente trabalho tem como objetivo relatar o tratamento de uma ferida em membro de equino por meio de métodos alternativos, com ênfase em sua eficácia e impactos no processo de cicatrização. A ferida foi causada por trauma acidental durante passeio e, apesar do tratamento convencional inicial, foi adicionado o uso de barbatimão na ferida. A abordagem terapêutica incluiu o uso de tratamentos alternativos, como fitoterápicos específicos para acelerar o processo de regeneração tecidual. O uso de plantas medicinais como Stryphnodendron barbadetiman, por exemplo, demonstrou benefícios por suas propriedades como anti-inflamatório e antimicrobianas, redução da inflamação e no aumento da vascularização local, minimizando o risco de infecções. A monitorização clínica, associada à análise da evolução da ferida, indicou um progresso significativo na recuperação do membro, com redução do tempo de cicatrização em comparação com tratamentos convencionais isolados. Observou-se ainda menor formação de tecido cicatricial excessivo, o que contribuiu para a preservação da funcionalidade do membro afetado. Conclui-se que os métodos alternativos, quando aplicados de forma integrativa e acompanhados por profissionais especializados, podem ser uma opção viável e eficaz no tratamento de feridas em equinos, representando um avanço significativo nas práticas veterinárias contemporâneas.
PROJETO “ELA PARA ELA”: UM RELATO DE EXPERIÊNCIA NA COMUNIDADE PINDOBAL
Authors: Silva Izabel Rodrigues da , Miranda Maisa Castelo Branco Couto de , Branco Yara Rocha Bastos Castelo , Macedo Lélia Lilianna Borges de Sousa 
Published: November 2024

O fisioterapeuta é um dos profissionais de saúde que pode e deve contribuir muito ao prestar atendimento às pessoas das comunidades carentes, pois é uma contribuição feita a uma parcela dos que estão excluídos ao acesso dos serviços de saúde como um todo. Com isso, identificou-se a necessidade de atendimento a mulheres em situação de vulnerabilização social em uma comunidade quilombola e indígena por se evidenciar dados relacionados a fatores de saúde desse público por serem mais fragilizadas quanto a falta de assistência aos serviços de saúde e dificuldades de acesso as informações. Sendo assim, buscou-se conscientizar as mulheres sobre os cuidados no período gestacional e puerperal. Este relato de experiencia mostra o quão positivo foi o desenvolvimento desse projeto na comunidade quilombola, o qual possibilitou uma atuação interdisciplinar na atenção básica e fisioterapêutica que se dispôs numa visão ampliada do processo terapêutico e de intervenção e /ou construção na busca dos enfrentamentos dos problemas de saúde. A ação foi efetiva no que tange à prevenção e promoção à saúde da população alvo e de todos os que a compunha que se torna mais bem capacitada para seu cuidado, dado o processo de conscientização; também permitiu uma visão mais ampla acerca das necessidades de atenção e cuidado requeridos pela população.
The Content Effectiveness of User-Generated Content to the Purchasing Decision of Consumers
Authors: De Vera Rod Martin 
Published: November 2024

The paper investigated the relationship between User-Generated Content (UGC) effectiveness and its influence on Filipino consumers' purchasing decisions. While the role of UGC in marketing was acknowledged, limited research explored its impact in the Philippines. The findings demonstrated a positive correlation between UGC content effectiveness and purchasing decisions. Content trustworthiness and content information richness were found to significantly influence consumer behavior. These results aligned with previous studies highlighting the importance of the credibility and informative content within UGC. The study offered valuable insights for businesses operating in the Philippines. UGC presented an economical and impactful marketing strategy, fostering brand trust, credibility, and connection with consumers. Recommendations included encouraging customer UGC creation and strategically utilizing various social media platforms. The research also highlighted the need for further exploration of UGC's effectiveness within specific industries and social media landscapes.
Comparative Analysis Of The Influence Of Capital Structure, Company Size, And Governance On Company Bankruptcy With Profit Quality As A Moderating Variable In The Period Before The Pandemic And During The Covid-19 Pandemic
Authors: Riyadi Yongki , Nugroho Lucky , Putra Yananto Mihadi , Gal Timea , Setiawan Audita 
Published: November 2024

This study uses earnings quality as a moderating variable to determine a comparative analysis of the effect of capital structure, firm size, and management on corporate bankruptcy. This quantitative study uses secondary data obtained and accessible through the website of the Indonesia Stock Exchange. The sample for this study consisted of 53 refined manufacturing companies. This study uses the purposive sampling method to select the desired sample. The analysis method of this study uses linear regression analysis and moderated regression analysis as analysis tools in Eviews 12. The results show that (1) Capital structure affects the company's bankruptcy in the phase 2015-2018, but not in the phase 2019-2022. (2) The size of the company does not affect the bankruptcy of the company in the phase 2015-2018, but it has an effect in the period 2019-2022 (3) The management, in this case, the ownership of the management, has an effect on the bankruptcy of the company also in 2015. -in phase 2018 and phase 2019-2022 (4) Institutional ownership affects the bankruptcy of the company and in the phases 2015-2018 and 2019-2022 (5) The quality of results does not affect the bankruptcy of the company in the 2015-2018 phase, but it has an effect in the 2019-2022 phase. (6) Earnings quality can slow company size to corporate bankruptcy in both phases, 2015-2018 and 2019-2022. (7) In the phase 2019-2022, the quality of the result can slow down the ownership.
Palladium‐Catalyzed Solvent‐Controlled Selective Synthesis of Acyl Isoureas and Imides from Amides, Isocyanides, Alcohols and Carboxylates
Authors: Cao Ming , Liu Liqiu , Tang Shi , Peng Zhiyuan , Wang Yingchun 
Published: December 2018

AbstractA highly selective synthesis of acyl isoureas and imides from readily accessible amides, isocyanides, alcohols and carboxylates based on reaction solvent selection is described. In the presence of a catalytic amount of [1,1′‐bis(diphenylphosphino)ferrocene]dichloropalladium(II) and cupric acetate, treatment of amides and isocyanides in alcohols at 60 °C provided acyl isoureas in high yields. Interestingly, when other solvents such as acetonitrile was used instead of alcohols, imides were exclusively produced in good to excellent yields via direct N‐acylation of amides with carboxylates as the acyl sources. This protocol offers an attractive alternative approach toward isoureas and imides.magnified image
C5‐Disubstituted Meldrum's Acid Derivatives as Platform for the Organocatalytic Synthesis of C3‐Alkylated Dihydrocoumarins
Authors: Martzel Thomas , Annibaletto Julien , Levacher Vincent , Brière Jean‐François , Oudeyer Sylvain 
Published: December 2018

AbstractC5‐disubstituted Meldrum's acid precursors were shown to be a useful platform for the synthesis of an array of 3‐alkylated dihydrocoumarins with up to 93:7 er, thanks to an enantioselective domino cyclization‐decarboxylative‐protonation reaction triggered by an unprecedented benzhydryl‐derived cupreine organocatalyst. This cyclization sequence was extended to an emerging organocatalytic decarboxylative‐chlorination reaction in the presence of trichloroquinolinone and by means of a bifunctional cinchona derived Brønsted base which gave rise to the formation of dihydrocoumarins (up to 79:21 er) with a tertiary chlorinated stereocenter.magnified image
Accessing MHz Operation at 2 V with Field‐Effect Transistors Based on Printed Polymers on Plastic
Authors: Perinot Andrea , Caironi Mario 
Published: December 2018

AbstractOrganic printed electronics are suitable for the development of wearable, lightweight, distributed applications in combination with cost‐effective production processes. Nonetheless, some necessary features for several envisioned disruptive mass‐produced products are still lacking: among these radio‐frequency (RF) communication capability, which requires high operational speed combined with low supply voltage in electronic devices processed on cheap plastic foils. Here, it is demonstrated that high‐frequency, low‐voltage, polymer field‐effect transistors can be fabricated on plastic with the sole use of a combination of scalable printing and digital laser‐based techniques. These devices reach an operational frequency in excess of 1 MHz at the challengingly low bias voltage of 2 V, and exceed 14 MHz operation at 7 V. In addition, when integrated into a rectifying circuit, they can provide a DC voltage at an input frequency of 13.56 MHz, opening the way for the implementation of RF devices and tags with cost‐effective production processes.
Muscle Expression of Type I and Type II Interferons Is Increased in Juvenile Dermatomyositis and Related to Clinical and Histologic Features
Authors: Moneta Gian Marco , Pires Marafon Denise , Marasco Emiliano , Rosina Silvia , Verardo Margherita , Fiorillo Chiara , Minetti Carlo , Bracci‐Laudiero Luisa , Ravelli Angelo , De Benedetti Fabrizio , Nicolai Rebecca 
Published: December 2018

ObjectiveTo evaluate the expression of type I interferon (IFNα/β)– and type II IFN (IFNγ)–inducible genes in muscle biopsy specimens from patients with juvenile dermatomyositis (DM) and to correlate their expression levels with histologic and clinical features.MethodsExpression levels of IFN‐inducible genes and proinflammatory cytokines were assessed by quantitative polymerase chain reaction in muscle biopsy specimens from patients with juvenile DM (n = 39), patients with Duchenne's muscular dystrophy (DMD), and healthy controls. Muscle biopsy sections were stained and scored for severity of histopathologic features. The charts of patients with juvenile DM were reviewed for clinical features at the time of sampling and long‐term outcomes.ResultsMuscle expression levels of IFNα/β‐inducible genes (type I IFN score), IFNγ, IFNγ‐inducible genes (type II IFN score), and tumor necrosis factor (TNF) were significantly higher in juvenile DM patients not receiving glucocorticoid therapy before muscle biopsy (n = 27) compared to DMD patients (n = 24) (type I IFN score, P < 0.0001; type II IFN score, P < 0.001; TNF, P < 0.05) and healthy controls (n = 4) (type I IFN score, P < 0.01; type II IFN score, P < 0.01; TNF, P < 0.05). Immunofluorescence staining of muscle biopsy sections from untreated juvenile DM patients showed increased immunoreactivity for IFNγ and HLA class II molecules compared to controls. Type I and type II IFN scores were correlated with typical histopathologic features of juvenile DM muscle biopsy samples, such as infiltration of endomysial CD3+ cells (type I IFN score, r = 0.68; type II IFN score, r = 0.63), perimysial CD3+ cells (type I IFN score, r = 0.59; type II IFN score, r = 0.66), CD68+ cells (type II IFN score, r = 0.46), and perifascicular atrophy (type I IFN score, r = 0.61; type II IFN score, r = 0.77). Juvenile DM patients with a high type I IFN score, a high type II IFN score, and high TNF expression levels showed more severe disease activity at biopsy (P < 0.05). In addition, juvenile DM patients with a high type II IFN score at biopsy reached clinically inactive disease significantly later than patients with low type II IFN score (log rank chi‐square value 13.53, P < 0.001).ConclusionThe increased expression of IFN‐inducible genes in the muscle in juvenile DM patients and their association with histologic and clinical features further support a pathogenic role for both type I and type II IFNs in juvenile DM.
A 14‐year‐old in heart failure with multiple cardiomyopathy variants illustrates a role for signal‐to‐noise analysis in gene test re‐interpretation
Authors: Connell Patrick S. , Jeewa Aamir , Kearney Debra L. , Tunuguntla Hari , Denfield Susan W. , Allen Hugh D. , Landstrom Andrew P. 
Published: December 2018

Key Clinical MessageVariants of unknown significance in cardiomyopathic disease should be analyzed systematically based on the prevalence of the variant in the population compared to prevalence of disease, evidence that other variants in the gene are pathologic, consistency of prediction software on pathogenicity, and the current clinical consensus.
Cutaneous metastasis of renal cell carcinoma: Fine needle aspiration provides rapid diagnosis
Authors: Mirza Rusella , Ellsworth Steven , King Judy , Sangster Guillermo , Shi Mingxia 
Published: December 2018

Key Clinical MessageThe diagnosis of cutaneous metastasis of renal cell carcinoma is challenging in a young person in absence of a prior history of cancer. In such situation, fine needle aspiration alone as a minimally invasive procedure can provide rapid, accurate and cost effective diagnosis, even in case of unknown primary.
Carbon Cloth‐supported MoS2/Ag2S/Ag3PO4 Composite with High Photocatalytic Activity and Recyclability
Authors: Liu Yuan , Wang Wenguang , Si Mingzhi , Zhang Haiyan 
Published: December 2018

AbstractThe immobilization of powdery photocatalysts has always been a key technology for its practical application in waste‐water purification. In this study, we successfully prepared carbon cloth‐supported MoS2/Ag2S/Ag3PO4 (CCMS‐AP) composite with high photocatalytic activity and good recyclable property for photodegradation of rhodamine B under visible light irradiation. The effects of immersion time of carbon cloth‐supported MoS2 in AgNO3 solution on the performance of the CCMS‐AP were investigated. The results show that the CCMS‐AP prepared with 6 h of immersion time exhibits the highest photocatalytic activity with a reaction rate constant of 42.9×10−3 min−1, which is 4.93 times higher than that of carbon cloth‐supported Ag3PO4. The direct Z‐scheme photocatalytic system is responsible for the efficient charge separation and strong oxidation ability of the composite. Moreover, the MoS2 and carbon fibers provid high speed charge transfer channels for photo‐generated electrons, leading to lower recombination rate of electron‐hole pairs and higher photocatalytic performance of the composite photocatalyst. Our strategy can be extended to fabricate many other recyclable carbon cloth‐supported photocatalysts with high performance that shows promising potential applications in wastewater treatment.
CytoML for cross‐platform cytometry data sharing
Authors: Finak Greg , Jiang Wenxin , Gottardo Raphael 
Published: December 2018

Abstract
CytoML is an R/Bioconductor package that enables cross‐platform import, export, and sharing of gated cytometry data. It currently supports Cytobank, FlowJo, Diva, and R, allowing users to import gated cytometry data from commercial platforms into R. Once data are available in R, the data can be further manipulated. For example it can be combined with other computational and analytic approaches, and the results can be exported to FlowJo or Cytobank to be explored by researchers using those platforms. We demonstrate how CytoML and related R packages can be used as a tool to import, modify and export several samples stained with the T cell panel from the FlowCAP IV Lyoplate data set. Once imported, the gating is modified using computational approaches, and exported for visualization in Cytobank and FlowJo. We further show how CytoML can be used to import gated data from a publicly accessible mass cytometry experiment from Cytobank. CytoML is the only tool that allows such sharing of gated cytometry data between researchers working across different platforms, and it will serve as a useful tool for validating and verifying the reproducibility of analyses. © 2018 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of International Society for Advancement of Cytometry.
Influence of comorbidity on therapeutic decision making and impact on outcomes in patients with head and neck squamous cell cancers: Results from a prospective cohort study
Authors: Agarwal JaiPrakash , Adulkar Deepanjali , Swain Monali , Chakraborty Santam , Gupta Tejpal , Budrukkar Ashwini , Ghosh‐Laskar Sarbani , Murthy Vedang 
Published: December 2018

AbstractBackgroundHigh prevalence of comorbidity in head and neck squamous cell carcinoma (HNSCC) often lead to suboptimal treatment. The presence study aims to evaluate the presence of comorbidity, its impact on therapeutic decision making, treatment compliance, and overall survival in HNSCC.MethodsFive hundred eighteen patients with nonmetastatic HNSCC, elder than 18 years of age, without any prior history of cancer or anticancer treatment in the last 5 years were evaluated using Adult Comorbidity Evaluation 27 (ACE 27) index.ResultsTwo hundred ninety three (56.6%) patients had comorbidity, and 20.6% had deviation from the ideal treatment plan. Higher grade of comorbidity led to less likely completion of guideline‐concordant therapy (moderate ACE 27 vs none: odds ratio [OR] 0.46, 95% confidence interval [CI] 0.26‐0.82, P < .01*; severe ACE 27 vs none: OR 0.23, 95% CI 0.08‐0.57, P < .01*). Patients who completed guideline‐concordant treatment had the best outcomes as compared to those who could not (median survival: not reached vs 9.56 months, hazard ratio 3.66, 95% CI: 2.8‐4.79; P < .01*).ConclusionPresence of increasing severity of comorbidity in HNSCC influences therapeutic decision making. Survival outcomes are poorer in patients receiving guideline‐discordant treatment.
Diagnostic value of computed tomography combined with ultrasonography in detecting cervical recurrence in patients with thyroid cancer
Authors: Hong Eun Kyoung , Kim Ji‐hoon , Lee Joongyub , Yoo Roh‐Eul , Kim Soo Chin , Kim Min Joo , Park Young Joo , Chung Eun‐Jae , Ryu Young Jin , Lee Eunjung , Kang Koung Mi , Yun Tae Jin , Choi Seung Hong , Sohn Chul‐Ho 
Published: December 2018

AbstractBackgroundTo determine the diagnostic role of CT added to ultrasound for the diagnosis of recurrent differentiated thyroid cancer (DTC) and to evaluate potential benefits for patients.MethodsA total of 193 patients with recurrent DTC were retrospectively included. The diagnostic performances of ultrasound and combination of ultrasound and CT (ultrasound/CT) in detecting recurrence were compared. Benefits of CT were assessed based on the presence of any recurrence detected only with additional CT.ResultsIn detecting cervical recurrence, ultrasound/CT showed higher sensitivity (P = .001) and lower specificity (P < .001) than ultrasound alone, overall resulting in higher area under the curve (P < .001). Seventy‐nine patients (40.9%) benefited from additional CT in detecting recurrence.ConclusionFor reoperation of cervical recurrence in patients with DTC, addition of CT to ultrasound offers better surgical planning by enhancing detection of recurrent cancers that were overlooked with ultrasound alone.
Prognostic value of C‐reactive protein/albumin ratio for patients with hypopharyngeal and laryngeal cancer undergoing invasive surgery involving laryngectomy
Authors: Kuboki Akihito , Kanaya Hiroaki , Nakayama Tsuguhisa , Konno Wataru , Goto Kazutaka , Nakajima Itsuo , Kashiwagi Takashi , Hirabayashi Hideki , Haruna Shin‐ichi 
Published: December 2018

AbstractBackgroundThe C‐reactive protein/albumin (CRP/Alb) ratio has been recently established as a prognostic indicator in various cancer types. However, few reports regarding the prognostic value of the CRP/Alb ratio in head and neck cancer exist. This study aimed to investigate the significance of the CRP/Alb ratio in clinical outcomes after invasive surgery involving laryngectomy for hypopharyngeal and laryngeal cancer.MethodsWe evaluated 56 patients who underwent total laryngectomy or total pharyngolaryngectomy between 2003 and 2012. Univariate and multivariate analyses were retrospectively performed to examine the prognostic value of the CRP/Alb ratio in these patients.ResultsThe optimal cutoff value of the CRP/Alb ratio was 0.32. Multivariate analysis showed that the CRP/Alb ratio was a significant and independent predictor of poor overall and disease‐free survival.ConclusionThe CRP/Alb ratio may be a novel and useful indicator for predicting postoperative outcomes in patients with hypopharyngeal and laryngeal cancer.