bluuebunny/crossref_metadata_2025_split huggingface dataset:
Versatile Multi-Detector Scheme for Adaptive Optics Scanning Laser Ophthalmoscopy
Authors: Mozaffari Sanam , Jaedicke Volker , Larocca Francesco , Tiruveedhula Pavan , Roorda Austin 
Published: September 2018

AbstractAdaptive Optics Scanning Laser Ophthalmoscopy (AOSLO) is a powerful tool for imaging the retina at high spatial and temporal resolution. In this paper, we present a multi-detector scheme for AOSLO which has two main configurations: pixel reassignment and offset aperture imaging. In this detection scheme, the single element detector of the standard AOSLO is replaced by a fiber bundle which couples the detected light into multiple detectors. The pixel reassignment configuration allows for more light throughput while maintaining optimal confocal resolution. The increase in signal-to-noise ratio (SNR) from this configuration can improve the accuracy of motion registration techniques. The offset aperture imaging configuration enhances the detection of multiply scattered light, which improves the contrast of retinal vasculature and inner retinal layers similar to methods such as nonconfocal split-detector imaging and multi-offset aperture imaging.
Comparative analysis of miR-155 tissue expression profiles of different breeds of chicken
Authors: Xu Sifan , Chang Yang , Wu Guanxian , Zhang Wanting , Man Chaolai 
Published: September 2018

AbstractmiR-155 is an important microRNA which has multiple functions in many physiological and pathological processes. In this study, partial pri-miR-155 sequences were cloned from AA+ broiler, Sanhuang broiler and Hi-Line Brown layer, respectively. Stem-loop RT-qPCR was performed to detect the miR-155 spatiotemporal expression profiles of each chicken breed. The results showed that the partial pri-miR-155 sequences of different breeds of chicken were high conserved. The expression patterns of miR-155 between broiler and layer were basically similar, and miR-155 is expressed highly in immune related tissues. Interestingly, miR-155 expression activity had higher level in fat tissue of the three chicken breeds (14-day-old), but it decreased significantly in fat of the Hi-Line Brown layer (10-month-old and 24-month-old). In addition, the expression activities of miR-155 in 14-day-old broilers (AA+ broiler and Sanhuang broiler) were significantly lower than that of Hi-Line Brown layer (14-day-old) (P<0.05). Moreover, miR-155 expression activities in skeletal muscle of 14-day-old and 10-month-old Hi-Line Brown layer were also significantly lower than that of 24-month-old layer (P<0.05). The results indicated that miR-155 might be one of the important factors affecting the differences in skeletal muscle development and adipogenesis between different chicken breeds. These data can serve as a foundation for further study the functions and mechanisms of miR-155 in the physiological and pathological contexts.
Unc93b1 recruits Syntenin-1 to dampen TLR7 signaling and prevent autoimmunity
Authors: Majer Olivia , Liu Bo , Krogan Nevan , Barton Gregory M. 
Published: September 2018

AbstractRecognition of nucleic acids enables detection of diverse pathogens by a limited number of innate immune receptors but also exposes the host to potential autoimmunity. At least two members of the Toll-like receptor (TLR) family, TLR7 and TLR9, can recognize self RNA or DNA, respectively. Despite the structural and functional similarities between these receptors, their contribution to autoimmune diseases such as SLE can be quite different. However, mechanisms of negative regulation that differentiate between TLR7 and TLR9 have not been described. Here we report a new function for the TLR trafficking chaperone Unc93b1 that specifically limits TLR7 signaling and prevents TLR7-dependent autoimmunity. Unc93b1 is known to traffic TLRs from the endoplasmic reticulum to endosomes, but this new regulatory function does not affect TLR7 localization. Instead, Unc93b1 recruits Syntenin-1, which inhibits TLR7, but not TLR9, signaling. Syntenin-1 binding requires phosphorylation of two serine residues on Unc93b1, providing a mechanism for dynamic regulation of the activation threshold of TLR7. Disruption of the Unc93b1/Syntenin-1 interaction in mice results in TLR7-dependent autoimmunity. Thus, Unc93b1 not only enables proper trafficking of nucleic acid sensing TLRs but also sets the activation threshold of these potentially self-reactive receptors.
Genome-Wide Control of Population Structure and Relatedness in Genetic Association Studies via Linear Mixed Models with Orthogonally Partitioned Structure
Authors: Conomos Matthew P. , Reiner Alex P. , McPeek Mary Sara , Thornton Timothy A. 
Published: September 2018

AbstractLinear mixed models (LMMs) have become the standard approach for genetic association testing in the presence of sample structure. However, the performance of LMMs has primarily been evaluated in relatively homogeneous populations of European ancestry, despite many of the recent genetic association studies including samples from worldwide populations with diverse ancestries. In this paper, we demonstrate that existing LMM methods can have systematic miscalibration of association test statistics genome-wide in samples with heterogenous ancestry, resulting in both increased type-I error rates and a loss of power. Furthermore, we show that this miscalibration arises due to varying allele frequency differences across the genome among populations. To overcome this problem, we developed LMM-OPS, an LMM approach which orthogonally partitions diverse genetic structure into two components: distant population structure and recent genetic relatedness. In simulation studies with real and simulated genotype data, we demonstrate that LMM-OPS is appropriately calibrated in the presence of ancestry heterogeneity and outperforms existing LMM approaches, including EMMAX, GCTA, and GEMMA. We conduct a GWAS of white blood cell (WBC) count in an admixed sample of 3,551 Hispanic/Latino American women from the Women’s Health Initiative SNP Health Association Resource where LMM-OPS detects genome-wide significant associations with corresponding p-values that are one or more orders of magnitude smaller than those from competing LMM methods. We also identify a genome-wide significant association with regulatory variant rs2814778 in the DARC gene on chromosome 1, which generalizes to Hispanic/Latino Americans a previous association with reduced WBC count identified in African Americans.
How can Shakespeare’s iambic pentameter enable inclusion of and encourage participation of autistic pupils in a year 7 boy’s mainstream classroom?
Authors: Gurnett Jane Elizabeth 
Published: September 2018

Purpose
The purpose of this paper is to facilitate a greater understanding of verbal and non-verbal communication in an open space learning (OSL) environment. This is an exploration of the premise that by using Shakespeare’s iambic pentameter as a scaffolding for learners on the autism spectrum, a “safe place” can be accessed.

Design/methodology/approach
Using an action research model and following government guidelines, using common assessment framework analysing the findings using School’s assessment criteria model that is used for single exercises through to whole scheme of work: making–performing–evaluating (self-evaluation sheets/peer evaluation sheets/teacher evaluation).

Findings
There has been hypothesis that people with ASD may be more able to track their heart beats for longer than neurotypicals. Kimberly et al. (2015) suggest that empathetic abilities and emotional experiences in people with ASD can produce negative experiences, anxiety can occur and the interoceptive awareness and ability to positively relate to self can be caused to dislocate. The use of the rhythm of the heartbeat may aid communication skills in ASD learners.

Research limitations/implications
In the autistic learner, overload, caused by hypersensitivity/hyposensitivity, can also affect and be effected by environmental issues in OSL environment. The autistic learner can be deeply affected. Unlike a desk-based class there is nowhere to hide, no place of safety.

Practical implications
By trying to find a common ground where the autistic learners can realise their full capacity the use of the heartbeat iambic rhythm can, the author posits, impact on the autistic learners sense of self and confidence, aiding learning.

Social implications
As Hunter (2015) espouses, the heartbeat is a nurturing instrument. The author advocates that the heartbeat is also a unilateral marker that unifies a class/the environment at the same time as comforting the autistic learner.

Originality/value
There is an element in every being that has to be present from inception, the heartbeat, it is the first function an embryo performs. The heartbeat also produces a primal symbiotic interdependency in mother and child. It is a pure connection. The author posits that the replication of this pure function can comfort, reassure and foster communication. There is no empirical evidence, but research is currently taking place at the Nisonger Centre at the Ohio State University, where, under the leadership of Dr Marc J. Tasse, pilot workshops have taken place. The author also have no empirical evidence as to why the heartbeat is instrumental in helping the autistic learner to communicate. The author gives the conjecture in the paper.
Autism and dual immersion: sorting through the questions
Authors: Baker Diana , Roberson Audrey , Kim Hyejung 
Published: September 2018

PurposeThe dual immersion (DI) model of bilingual education, which focuses on educating language-minority and majority students side by side using the two languages in roughly equal proportions, is gaining popularity. And yet, students with disabilities – even those who are already multilingual – are routinely steered away from such programs in favor of English-only special education options. The paper aims to discuss these issues.Design/methodology/approachThis paper explores the potential benefits and challenges associated with including multilingual students with autism in DI classrooms, beginning with an exploration of literature related to students with autism who are also multilingual learners (MLLs) (irrespective of educational placement), followed by a small body of literature on the inclusion of students with disabilities in general in DI programs, and finally an analysis of the characteristics of DI classrooms to extrapolate about the ways in which this environment might be both supportive of and challenging for students with autism.FindingsThe analysis reveals that DI programs are simultaneously well positioned (theoretically) and ill equipped (practically) to effectively support MLLs who are also on the autism spectrum.Originality/valueIn spite of mounting evidence that being multilingual may advantage children with autism, very little scholarship has even raised the question of whether students with autism might benefit from participation in bilingual programs where academic instruction is delivered in two languages (Beauchamp and MacLeod, 2017; Durán et al., 2016; Marinova-Todd et al., 2016; Seung et al., 2006). This paper identifies practical implications related to including students with autism in DI programs and suggests directions for future research.
Consumer-directed care and the relational triangle
Authors: Payne Graeme Edward , Fisher Greg 
Published: September 2018

PurposeFollowing a recent government initiated change to a consumer-directed care model across the Australian community aged care sector, the purpose of this paper is to explore frontline home support workers’ perceptions of relational changes with clients in power and subordination within the triadic relationship between employer, employee and client.Design/methodology/approachContextual interviews were held with managers (n=4), coordinators (n=10) and semi-structured face-to-face interviews with support workers (n=17) in three organizations. Interview transcripts were analyzed.FindingsSome workers did not perceive a power change in their relationships with clients. Others perceived minimal change but were concerned about the incoming client generation (baby boomers) that were more aware of their rights. Others felt subordinated to the client, perceived a loss of control or that felt treated like an employee of the client. Consistent with the philosophy of consumer-directed care, senior staff encouraged clients to treat workers in this way.Research limitations/implicationsFurther research is recommended on worker and client perceptions of relationships within the context of a consumer or client focused model.Practical implicationsA clear and realistic understanding of the locus of power within a triadic relationship by all actors is important for positive workplace outcomes.Social implicationsThe increasing ageing population makes it essential that workers’ relationships with clients and with their organization are unambiguous.Originality/valueThis study makes a contribution to theories about change and power transfer in the implementation of consumer-directed care through the perceptions of support workers. Examination of power and subordination transfer through the perceptions of the actors of rather than through the prism of organizational policy deepens the understanding of frontline service work and relationships.
Beyond customer experience models: identifying idiosyncratic perceptions
Authors: Gorgoglione Michele , Panniello Umberto 
Published: September 2018

Purpose
The purpose of this paper is to demonstrate that a deeper analysis of customer experience (CE) can identify idiosyncratic and critical perceptions in the experiences of groups of customers.

Design/methodology/approach
The methodology that the authors used is made of three main steps: segmentation analysis, profiling and identification of idiosyncratic clusters’ profiles (i.e. those with a CE perception different respect to the whole sample) and among these idiosyncratic clusters, identification of those that may be critical for the business.

Findings
The authors identified clusters of customers showing significant differences in their perceived experience with respect to the holistic CE model. Nevertheless, a sample of bank managers assessed three cluster profiles among them to be critical signals a company. The identification of these idiosyncratic patterns provides managers with interesting additional insights that would be hidden in a holistic CE model.

Practical implications
Managers can gain valuable insights of CE from this analysis that should be added to those coming from an holistic CE model.

Originality/value
This paper contributes to the scientific research in that it extends the knowledge about CE by showing how personal factors can be identified and how drawing additional managerial insights.
Towards an approach for monetary valuation of services
Authors: Hsiao Ming-Hsiung 
Published: September 2018

Purpose
The purpose of this study is to suggest possible approach which can be applied to estimate the monetary value of the ancillary services in today’s multichannel environment where consumers tend to exhibit cross-channel purchase behavior across the online and offline.

Design/methodology/approach
This study conducts literature reviews to identify ancillary services and discuss their service paths across online and offline channels based on service-dominant logic. It then proposes discrete choice modeling approach with stated preference data to estimating the implicit value of services.

Findings
By examining consumer decision-making process, some ancillary services attached to the products/services that consumers target at are revealed and discussed. By applying the discrete choice modeling approach which have been widely applied in the marketing and transportation area to describe consumers’ multichannel choices, it is believed that the implicit value that consumers are willing to pay for having those ancillary services can be estimated.

Originality/value
Value is generally considered transitory, stochastic and multidimensional and understood imprecisely. Past research recognized the importance of value to the service industry, but failed to give it a widely accepted definition. Issues on the value of time, value of information and value of services have been widely discussed in the literature, but most of them remained unsolved. The approach proposed by this study to estimating the value of services seems practicable and is worth a further validation by empirical study.
Spanish and Swedish eldercare managers’ influence on employees
Authors: Nordin Maria , Romeo Marina , Yepes-Baldó Montserrat , Westerberg Kristina 
Published: September 2018

Purpose
Hierarchical and flat organizational types are predominant in Spain and Sweden, respectively. To study how managers’ commitment and work overcommitment (WOC) affect employee well-being, and job perception in these different countries can shed insight on how to improve eldercare organization. The purpose of this paper was to study the association between eldercare employee exposure to managers’ commitment and WOC, and employee mental well-being and job perception and how these associations differed between Spain and Sweden.

Design/methodology/approach
A questionnaire with validated questions on commitment, WOC, mental well-being and job perception, operationalized as the perception of quality of care and turnover intent, was sent out to eldercare managers and employees in Spain and Sweden. t-Tests, χ2 and linear regression were applied to study the associations and differences between the countries.

Findings
Interaction analyses revealed that Spanish employees’ mental well-being and job perception were influenced by their managers’ commitment and WOC in that manager commitment improved and WOC impaired well-being and job perception. However, the Swedish eldercare employees were not influenced by their managers on these parameters.

Practical implications
The impact of managerial commitment and WOC differed between employees in Spain and Sweden, possibly because the preconditions for leadership varied due to differences in organizational type.

Originality/value
This study compares the managers’ impact on employee health and job perception in two countries with different organizational prerequisites. Moreover, managers’ commitment and WOC were estimated by the managers themselves and did not rely on the employees’ perception, which improved ecological validity.
Attachment style, psychotic phenomena and the relationship with aggression: an investigation in a general population sample
Authors: Whale Katherine , Green Kathleen , Browne Kevin 
Published: September 2018

PurposeThe purpose of this paper is to explore the relationship between attachment style, sub-clinical symptoms of psychosis and aggression in a general population sample.Design/methodology/approachUsing both convenience and snowball sampling, participants in the community (n=213) completed an online questionnaire including previously validated measures of adult attachment, aggression and psychotic experiences.FindingsResults suggested that there were statistically significant correlations between all study variables. Multiple linear regression demonstrated that total psychotic-like experiences and attachment scores significantly predicted variance in total aggression. Moderation approaches revealed that the relationship between psychotic-like events and aggression was stronger in individuals with more insecure attachment styles.Research limitations/implicationsThis generalisability of the results is compromised by the sampling methodology and the use of self-report tools. However, the significant results would support larger scale replications investigating similar variables.Originality/valueThis study suggests there is a relationship between psychotic-like experiences (PLEs) and facets of aggression in the general population. These results suggest that attachment is a contributing factor to aggression associated with PLEs, and highlight the need for similar investigations within clinical samples. The results imply that attachment may be a useful construct for explanatory models of the relationship between adverse childhood experiences, psychotic experiences and aggression.
Assumption, the mother of all foul ups: a fundamental reason for the continuing abuse of adults at risk
Authors: Moore Steve 
Published: September 2018

Purpose
The purpose of this paper is to introduce the concept of the assumption of altruism argued by the author to be a tendency among both the lay public, professionals and politicians, a generalised assumption that contributes to the long standing and obstinate presence of abuse of adults who are at risk throughout England, particularly older people living in care and nursing homes.

Design/methodology/approach
By examining available figures that depict the continuing abuse of vulnerable adults, and by drawing on research, the author offers a partial explanation for the longevity of abuse in English society.

Findings
The paper demonstrates how the concept of the assumption of altruism can explain to a degree the apparent enduring levels of abuse of adults who are at risk.

Practical implications
The paper offers the opportunity for the reader to consider some of the fundamental, higher order reasons for the persistent levels of abuse in England, abuse that endures despite the oversight by government of care provided to adults who maybe at risk by virtue of the activities of the statutory regulator and health and social care commissioners.

Originality/value
By presenting the incontrovertible evidence of enduring abuse, the paper introduces the concept of the assumption of altruism as a partial explanation for its continuing occurrence despite decades of policy and practice guidance designed to overcome it.
Perceptions of teaching staff in human services about academic entitlement
Authors: Heffernan Kristin , Gates Trevor G. 
Published: September 2018

Purpose
The purpose of this paper is to explore how perceived student entitlement influences the work experiences of a sample of teaching staff in human services, counselor education and social work.

Design/methodology/approach
To examine the relationship between perceived academic entitlement and job-related affective well-being among teaching staff in social work, counseling and human services, a cross-sectional design was utilized. To be eligible for the study, participants must have been 18 years of age and currently employed as teaching staff in a human service program in the USA.

Findings
A convenience sample of 118 teaching staff demonstrated that negative well-being is correlated with perceptions of academic entitlement. It also revealed that teaching staff with a lower academic rank perceived their students to be more entitled, suggesting that pressures of working toward tenure may influence these professors’ behaviors making them more accommodating to students. Accommodating behavior may be driven by a need for favorable teaching evaluations but impacts the quality of education a student receives.

Originality/value
These data shed light on the relationship between perceived student academic entitlement and job-related affective well-being among human service teaching staff and consider how a shift in students’ expectations influences the behaviors of teaching staff.