bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Performance Flexible Thermoelectric Devices Based on All‐Inorganic Hybrid Films for Harvesting Low‐Grade Heat
Authors: Wu Bo , Guo Yang , Hou Chengyi , Zhang Qinghong , Li Yaogang , Wang Hongzhi 
Published: April 2019

AbstractThe fabrication of a flexible thermoelectric (TE) device that contains flexible, all‐inorganic hybrid thin films (p‐type single‐wall carbon nanotubes (SWCNTs)/Sb2Te3 and n‐type reduced graphene oxide (RGO)/Bi2Te3) is reported. The optimized power factors of the p‐type and n‐type hybrid thin films at ambient temperature are about 55 and 108 µW m−1 K−2, respectively. The high performance of these films that are fabricated through the combination of vacuum filtration and annealing can be attributed to their planar orientation and network structure. In addition, a TE device, with 10 couples of legs, shows an output power of 23.6 µW at a temperature gradient of 70 K. A prototype of an integrated photovoltaic‐TE (PV‐TE) device demonstrates the ability to harvest low‐grade “waste” thermal energy from the human body and solar irradiation. The flexible TE and PV‐TE device have great potential in wearable energy harvesting and management.
TPP1 Delivery to Lysosomes with Extracellular Vesicles and their Enhanced Brain Distribution in the Animal Model of Batten Disease
Authors: Haney Matthew J. , Klyachko Natalia L. , Harrison Emily B. , Zhao Yuling , Kabanov Alexander V. , Batrakova Elena V. 
Published: April 2019

AbstractExtracellular vesicles (EVs) are promising natural nanocarriers for delivery of various types of therapeutics. Earlier engineered EV‐based formulations for neurodegenerative diseases and cancer are reported. Herein, the use of macrophage‐derived EVs for brain delivery of a soluble lysosomal enzyme tripeptidyl peptidase‐1, TPP1, to treat a lysosomal storage disorder, Neuronal Ceroid Lipofuscinoses 2 (CLN2) or Batten disease, is investigated. TPP1 is loaded into EVs using two methods: i) transfection of parental EV‐producing macrophages with TPP1‐encoding plasmid DNA (pDNA) or ii) incorporation therapeutic protein TPP1 into naive empty EVs. For the former approach, EVs released by pretransfected macrophages contain the active enzyme and TPP1‐encoding pDNA. To achieve high loading efficiency by the latter approach, sonication or permeabilization of EV membranes with saponin is utilized. Both methods provide proficient incorporation of functional TPP1 into EVs (EV‐TPP1). EVs significantly increase stability of TPP1 against protease degradation and provide efficient TPP1 delivery to target cells in in vitro model of CLN2. The majority of EV‐TPP1 (≈70%) is delivered to target organelles, lysosomes. Finally, a robust brain accumulation of EV carriers and increased lifespan is recorded in late‐infantile neuronal ceroid lipofuscinosis (LINCL) mouse model following intraperitoneal administration of EV‐TPP1.
Design of Bistable Gold@Spin‐Crossover Core–Shell Nanoparticles Showing Large Electrical Responses for the Spin Switching
Authors: Torres‐Cavanillas Ramón , Sanchis‐Gual Roger , Dugay Julien , Coronado‐Puchau Marc , Giménez‐Marqués Mónica , Coronado Eugenio 
Published: April 2019

AbstractA simple chemical protocol to prepare core–shell gold@spin‐crossover (Au@SCO) nanoparticles (NPs) based on the 1D spin‐crossover [Fe(Htrz)2(trz)](BF4) coordination polymer is reported. The synthesis relies on a two‐step approach consisting of a partial surface ligand substitution of the citrate‐stabilized Au NPs followed by the controlled growth of a very thin layer of the SCO polymer. As a result, colloidally stable core@shell spherical NPs with a Au core of ca. 12 nm and a thin SCO shell 4 nm thick, are obtained, exhibiting a narrow distribution in sizes. Differential scanning calorimetry proves that a cooperative spin transition in the range 340–360 K is maintained in these Au@SCO NPs, in full agreement with the values reported for pristine 4 nm SCO NPs. Temperature‐dependent charge‐transport measurements of an electrical device based on assemblies of these Au@SCO NPs also support this spin transition. Thus, a large change in conductance upon spin state switching, as compared with other memory devices based on the pristine SCO NPs, is detected. This results in a large improvement in the sensitivity of the device to the spin transition, with values for the ON/OFF ratio which are an order of magnitude better than the best ones obtained in previous SCO devices.
Cobalt‐Catalyzed Allylic Alkylation Enabled by Organophotoredox Catalysis
Authors: Takizawa Koji , Sekino Tomoyuki , Sato Shunta , Yoshino Tatsuhiko , Kojima Masahiro , Matsunaga Shigeki 
Published: April 2019

AbstractCo‐catalyzed allylic substitution reactions have received little attention, arguably because of the lack of any known advantage of Co catalysis over either Rh or Ir catalysis. Described here is a general and regioselective Co‐catalyzed allylic alkylation using an in situ catalyst activation by organophotoredox catalysis. This noble‐metal‐free catalytic system exhibits unprecedentedly high reactivities and regioselectivities for the allylation with an allyl sulfone, for the first time, representing the unique synthetic utility of the Co‐catalyzed method compared to the related Rh‐ and Ir‐catalyzed reactions.
Eine Kupfer‐katalysierte N‐F‐Bindungsaktivierung für die einheitliche intramolekulare C‐H‐Aminierung zu Pyrrolidinen und Piperidinen
Authors: Bafaluy Daniel , Muñoz‐Molina José Maria , Funes‐Ardoiz Ignacio , Herold Sebastian , de Aguirre Adiran , Zhang Hongwei , Maseras Feliu , Belderrain Tomás R. , Pérez Pedro J. , Muñiz Kilian 
Published: April 2019

AbstractDie Bifunktionalität der N‐F‐Bindung als wirksames Oxidationsmittel und nachfolgende Stickstoffquelle in intramolekularen aliphatischen C‐H‐Funktionalisierungen wird untersucht. Dabei wird gezeigt, dass eine Kupferkatalyse eine vollständige Regio‐ und Chemoselektivitätskontrolle ermöglicht, wodurch neue Synthesewege zu stickstoffhaltigen Heterozyklen mit vorhersagbarer Ringgröße geebnet werden. Für den Aufbau von Pyrrolidin‐ und Piperidinringen wird erstmals ein einheitlicher Katalysezyklus identifiziert. Die einzelnen Schritte dieser neuen Kupferoxidationskatalyse werden durch Kontrollexperimente und Computerstudien aufgeklärt, um die Einzigartigkeit der N‐F‐Funktion zu belegen und die Katalyse als einen Kupfer(I/II)‐Zyklus zu charakterisieren.
Interfacial Defect Engineering for Improved Portable Zinc–Air Batteries with a Broad Working Temperature
Authors: An Li , Huang Bolong , Zhang Yu , Wang Rui , Zhang Nan , Dai Tengyuan , Xi Pinxian , Yan Chun‐Hua 
Published: April 2019

AbstractAtomic‐thick interfacial dominated bifunctional catalyst NiO/CoO transition interfacial nanowires (TINWs) with abundant defect sites display high electroactivity and durability in the oxygen evolution reaction (OER) and the oxygen reduction reaction (ORR). Density functional theory (DFT) calculations show that the excellent OER/ORR performance arises from the electron‐rich interfacial region coupled with defect sites, thus enabling a fast‐redox rate with lower activation barrier for fast electron transfer. When assembled as an air‐electrode, NiO/CoO TINWs delivered the high specific capacity of 842.58 mAh gZn−1, the large energy density of 996.44 Wh kgZn−1 with long‐time stability of more than 33 h (25 °C), and superior performance at low (−10 °C) and high temperature (80 °C).
Gold Difluorocarbenoid Complexes: Spectroscopic and Chemical Profiling
Authors: Tskhovrebov Alexander G. , Lingnau Julia B. , Fürstner Alois 
Published: April 2019

AbstractGold carbenes of the general type [LAu=CR2]+ are sufficiently long‐lived for spectroscopic inspection only if the substituents compensate for the largely missing stabilization of the carbene center by the [LAu]+ fragment. π‐Donation by two fluorine substituents (R=F) is insufficient; rather, difluorocarbene complexes are so deprived in electron density that they sequester even “weakly coordinating” anions such as triflate or triflimide. This particular bonding situation translates into unmistakable carbenium ion chemistry upon reaction with stilbene as a model substrate.
Role of cytokines in combinatorial immunotherapeutics of non‐small cell lung cancer through systems perspective
Authors: Misra Pragya , Singh Shailza 
Published: April 2019

AbstractLung cancer is the leading cause of deaths related to cancer and accounts for more than a million deaths per year. Various new strategies have been developed and adapted for treatment; still the survival for 5 years is just 16% in patients with non‐small cell lung cancer (NSCLC). Most of these strategies to combat NSCLC whether it is a drug molecule or immunotherapy/vaccine candidate require a big cost and time. Integration of computational modeling with systems biology has opened new avenues for understanding complex cancer biology. Resolving the complex interactions of various pathways and their crosstalk leading to oncogenic changes could identify new therapeutic targets with lesser cost and time. Herein, this review provides an overview of various aspects of NSCLC along with available strategies for its cure concluding with our insight into how systems approach could serve as a therapeutic intervention dissecting the immunologic parameters and cross talk between various pathways involved.
Discovery of a Highly Active Catalyst for Hydrogenolysis of C−O Bonds via Systematic, Multi‐metallic Catalyst Screening
Authors: van Muyden Antoine P. , Siankevich Sviatlana , Yan Ning , Dyson Paul J. 
Published: April 2019

AbstractHydrogenolysis of C−O bonds is a highly challenging reaction with the most efficient catalysts based on bimetallic assemblies. Systematic studies to identify the optimum metal combination have not been performed and, therefore, we designed a method to screen multi‐metallic catalysts, including all water stable transition metals, using diphenyl ether as a model substrate. Bimetallic Pd−Pt (70 : 30) nanoparticles were the most efficient, catalyzing the hydrogenolysis of the C−O bond in diphenyl ether at 95 °C and 1 atm of hydrogen in quantitative yield. This research provides insights into the activity of multi‐metallic catalysts in hydrogenolysis reactions. The catalyst was successfully applied in the reductive fractionation of bio‐mass affording key products in near‐quantitative yields.
Highly Porous Metalloporphyrin Covalent Ionic Frameworks with Well‐Defined Cooperative Functional Groups as Excellent Catalysts for CO2 Cycloaddition
Authors: Liu Jiahui , Zhao Guoying , Cheung Ocean , Jia Lina , Sun Zhenyu , Zhang Suojiang 
Published: April 2019

AbstractThe development of multifunctional heterogeneous catalysts with high porosity and remarkable catalytic activity still remains a challenge. Herein, four highly porous metalloporphyrin covalent ionic frameworks (CIFs) were synthesized by coupling 5,10,15,20‐tetrakis(4‐nitrophenyl)porphyrin (TNPP) with 3,8‐diamino‐6‐phenylphenanithridine (NPPN) or 5,5′‐diamino‐2,2′‐bipyridine (NBPy) followed by ionization with bromoethane (C2H5Br) or dibromoethane (C2H4Br2) and then metalization with Zn or Co. The resulting CIFs showed high efficiency in catalyzing the cycloaddition of propylene oxide (PO) with CO2 to form propylene carbonate (PC). All of the Zn‐containing CIF catalysts were able to catalyze the cycloaddition reaction with a PC yield greater than 97 %. The TNPP/NBPy (CIF2) catalyst ionized with C2H4Br2 and metalized with Zn (Zn‐CIF2‐C2H4) exhibited the highest catalytic activity among the synthesized catalysts. The high catalytic performance of Zn‐CIF2‐C2H4 is related to its high porosity (577 m2 g−1), high Br:metal ratio (1:3.89), and excellent synergistic action between the Lewis acidic Zn sites and the nucleophilic Br− ions. Zn‐CIF2‐C2H4 is sufficiently stable that greater than 94 % PC yield could be obtained even after six cycles. In addition, Zn‐CIF2‐C2H4 could catalyze the cycloaddition of several other epoxides with CO2. These highly porous materials are promising multifunctional and efficient catalysts for industrially relevant reactions.
Synthesis of Highly Functionalized N,N‐Diarylamides by an Anodic C,N‐Coupling Reaction
Authors: Dörr Maurice , Lips Sebastian , Martínez‐Huitle Carlos Alberto , Schollmeyer Dieter , Franke Robert , Waldvogel Siegfried R. 
Published: April 2019

AbstractWe report an innovative, sustainable and straightforward protocol for the synthesis of N,N‐diarylamides equipped with nonprotected hydroxyl groups by using electrosynthesis. The concept allows the application of various substrates furnishing diarylamides with yields up to 57 % within a single and direct electrolytic protocol. The method is thereby easy to conduct in an undivided cell with constant current conditions offering a versatile and short‐cut alternative to conventional pathways.
An Efficient Photocatalyst Based on Black TiO2 Nanoparticles and Porous Carbon with High Surface Area: Degradation of Antibiotics and Organic Pollutants in Water
Authors: Fang Yu , Li Yuanyuan , Zhou Feng , Gu Peiyang , Liu Jiadi , Chen Dongyun , Li Najun , Xu Qingfeng , Lu Jianmei 
Published: April 2019

AbstractPorous carbon (PC) materials with high surface area can separate electron–hole pairs and adsorb organic pollutants more effectively. A series of nanocomposites were prepared by anchoring black TiO2 nanoparticles (BTN) onto PC through a calcination process. Chemical and structural features of samples were examined by X‐ray photoelectron spectroscopy (XPS), Raman spectroscopy, powder X‐ray diffraction (P‐XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses. The resulting adsorption‐photocatalysis synergistic effect led to a dramatically improved photocurrent for BTN@PCs, thus indicating the high photocatalytic performance toward water‐soluble organic species. For instance, the degradation of tetracycline under visible light reached 90 %, which is higher than that for activated carbon doped onto BTN (57 %) without any additional agents. Moreover, the degradation of other antibiotics (such as oxytetracycline and ciprofloxacin) and methylene blue were also studied, thus showing that this system has the potential to be used for water treatment.
Trimodality therapy for oropharyngeal cancer in the TORS era: Is there a cohort that may benefit?
Authors: Gallitto Matthew , Sindhu Kunal , Wasserman Isaac , De Brian , Gupta Vishal , Miles Brett A. , Genden Eric M. , Posner Marshall , Misiukiewicz Krzysztof , Bakst Richard L. 
Published: April 2019

AbstractBackgroundWith increasing adoption of transoral robotic surgery (TORS) for oropharyngeal cancer (OPC), more patients may receive trimodality therapy. We sought to investigate outcomes and toxicities in this cohort.MethodsA retrospective study of patients with OPC treated with trimodality therapy at a tertiary‐care hospital, comparing those receiving bilateral vs unilateral neck radiation.ResultsFour hundred thirty‐six patients underwent TORS, 17% receiving adjuvant chemoradiation. Of the 46 patients completing adjuvant treatment in‐house, contralateral neck was spared in 20%. There were no significant differences in survival, and patient‐reported outcomes in salivary function, mood, and anxiety were superior in those patients receiving unilateral neck radiation and directly correlated with mean dose to local structures.ConclusionsSurgery for OPC offers the potential for reduction in radiation volumes by omitting the contralateral neck in those who may have required definitive chemoradiation. Even in patients receiving concurrent chemotherapy, unilateral neck radiation has a favorable toxicity profile without compromising survival.
High expression of miR‐338 is associated with poor prognosis in acute myeloid leukemia undergoing chemotherapy
Authors: Fu Lin , Qi Jialei , Gao Xiang , Zhang Ninghan , Zhang Huihui , Wang Rong , Xu Linyan , Yao Yao , Niu Mingshan , Xu Kailin 
Published: April 2019

AbstractAcute myeloid leukemia (AML) is a heterogeneous disease with unfavorable outcomes. MicroRNAs (miRNAs) are important regulators and prognostic factors involved in AML. To determine the clinical role of miR‐338 in AML, a total of 164 adults with de novo AML were collected. These patients were classified into a chemotherapy group and an allogeneic hematopoietic stem cell transplantation (allo‐HSCT) group according to the clinical treatment, and then each group was divided into two subgroups based on the median miR‐338 expression values. We found that upregulated miR‐338 positively correlates with higher frequencies of complex karyotype, RUNX1 mutation, and poor risk status. In the chemotherapy group, high expression of miR‐338 was independently associated with shorter EFS and OS. However, no significant differences were observed between the two subgroups within the allo‐HSCT group. We also divided all patients into two groups according to the median miR‐338 expression values of the whole cohort. In the miR‐338 high expression group, patients receiving allo‐HSCT had longer OS and EFS than those receiving chemotherapy only. In contrast, patients receiving different therapies had similar OS and EFS in the miR‐338 low expression group. Our study suggests that high expression of miR‐338 is an adverse prognostic biomarker in patients with AML undergoing chemotherapy and may guide treatment decisions for AML. Furthermore, allo‐HSCT could significantly overcome the negative effect of high miR‐338 expression, but it seemed to be unbeneficial and unnecessary for low miR‐338 expressions.
The Influence of Proinflammatory Cytokines on Voriconazole Trough Concentration in Patients With Different Forms of Hematologic Disorders
Authors: Mafuru Magesa , Wu Sanlan , He Sijie , Lu Xuan , Huang Jiangeng , Jiang Hongliang 
Published: April 2019

AbstractEven though multiple factors are involved in the high fluctuation of voriconazole (VCZ) plasma concentration, little is known regarding the influence of proinflammatory cytokines on VCZ concentration. The aim of this study was to investigate the influence of proinflammatory cytokines, namely, interleukin (IL)‐1β, IL‐6, IL‐18, interferon‐γ, tumor necrosis factor‐α, and transforming growth factor (TGF)‐β1 on VCZ trough concentration (VCZ‐Cmin) in Chinese patients with different forms of hematologic disorders. A total of 250 plasma samples from 113 patients were analyzed for VCZ‐Cmin and proinflammatory cytokines using a validated liquid chromatography–tandem mass spectrometry and enzyme‐linked immunosorbent assay methods, respectively. Patient demographics and clinical characteristics were obtained from hospital records. VCZ‐Cmin was significantly correlated with IL‐18 in acute myeloid leukemia (r = 0.456; P ˂ .0001), acute lymphoblastic leukemia (r = 0.317; P = .019), and chronic myeloid leukemia (r = 0.737; P = .004) while VCZ‐Cmin and TGF‐β1 were correlated (r = 0.436; P ˂ .001) in acute myeloid leukemia patients only. VCZ‐Cmin at different concentration range showed significant inhibitory effect of IL‐6. A backward multiple linear regression model revealed patient age (coefficient [β] = 0.025; P = .04), gamma‐glutamyl transferase (β = 0.003; P = .023), IL‐6 (β = –0.001; P = .024), proton pump inhibitor coadministration (β = 1.518; P = .002), and cytochrome P450 (CYP) 2C19 polymorphism as predictors of VCZ‐Cmin; however, these factors explained only 29% of VCZ‐Cmin variation. In conclusion, IL‐18 and TGF‐β1 have correlation with VCZ‐Cmin in Chinese patients with leukemia. Apparently, VCZ may have an inhibitory effect on IL‐6 levels. Furthermore, patient age, gamma‐glutamyl transferase, IL‐6, PPI coadministration, and cytochrome P450 2C19 polymormorphism partially predicted the VCZ‐Cmin. Therapeutic drug monitoring of VCZ in Chinese patients is highly encouraged.
The effect of risk communication on periodontal treatment outcomes: A randomized controlled trial
Authors: Asimakopoulou Koula , Nolan Matthew , McCarthy Claire , Newton Jonathan T. 
Published: April 2019

AbstractBackgroundThis study determines the effects of a routine assessment (Treatment as Usual, TAU) versus a risk communication intervention (Risk) versus a Goal‐Setting, Planning and Self‐Monitoring (GPS) intervention on periodontal disease patients’ clinical and psychological outcomes.MethodsIn a three‐arm randomized controlled trial (RCT; registration: ISRCTN59696243) adults (N = 97) judged to have moderate oral hygiene attended a primary dental care setting for a standard consultation. Intervention participants received an individualized calculation of their periodontal disease risk using only the Previser Risk Calculator (Risk group) or supplemented with a GPS‐behavioral intervention (GPS group). Clinical, behavioral and psychological measures were obtained at baseline, 4 and 12 weeks later.ResultsPercent plaque reduced significantly (P < 0.05) in intervention groups but not in TAU group. Percent of sites bleeding‐on‐probing reduced in all groups, but the effect was more pronounced in the intervention groups. Interdental cleaning frequency improved only in the intervention groups (P < 0.05). Brushing frequency and probing depths showed little variation across time/groups. Disease risk and most thoughts about periodontal disease changed across time (P < 0.05).ConclusionsA simple behavioral intervention using individualized periodontal disease risk communication, with or without GPS, reduced plaque and bleeding and increased interdental cleaning over 12 weeks. This is the first study in the field to show that risk communication and behavioral techniques such as Goal‐Setting, Planning and Self‐Monitoring can improve periodontal outcomes.
Polydopamine‐coated cotton fibers as the adsorbent for in‐tube solid‐phase microextraction
Authors: Feng Juanjuan , Sun Min , Han Sen , Ji Xiangping , Li Chunying , Wang Xiuqin , Tian Yu 
Published: April 2019

AbstractPolydopamine was coated onto cotton fibers as the adsorbent to improve the extraction efficiency. Polydopamine‐coated cotton fibers were placed into a polyetheretherketone tube for in‐tube solid‐phase microextraction. To develop an online analysis system, the extraction tube was connected with high‐performance liquid chromatography. The tube was evaluated with five estrogenic analytes, and the extraction and desorption conditions were optimized to get high extraction efficiency. Under the optimum conditions, the enrichment factors of five analytes were 143–1745. An online analysis method was established, it had large linear ranges (0.10–40 and 0.16–40 μg/L), low limits of detection (0.03, 0.05 μg/L) and satisfactory repeatability (≤3.2%). The analysis method was applied to detect targets in the real samples like as hot water in new plastic cup and tap water. The relative recoveries spiked at 1 and 5 μg/L in these samples were investigated and the results were in the range of 83.7–109%.