bluuebunny/crossref_metadata_2025_split huggingface dataset:
Misophonia is associated with altered brain activity in the auditory cortex and salience network
Authors: Schröder Arjan , van Wingen Guido , Eijsker Nadine , San Giorgi Renée , Vulink Nienke C. , Turbyne Collin , Denys Damiaan 
Published: May 2019

AbstractMisophonia is characterized by intense rage and disgust provoked by hearing specific human sounds resulting in social isolation due to avoidance. We exposed patients with symptom provoking audiovisual stimuli to investigate brain activity of emotional responses. 21 patients with misophonia and 23 matched healthy controls were recruited at the psychiatry department of the Amsterdam UMC. Participants were presented with three different conditions, misophonia related cues (video clips with e.g. lip smacking and loud breathing), aversive cues (violent or disgusting clips from movies), and neutral cues (video clips of e.g. someone meditating) during fMRI. Electrocardiography was recorded to determine physiological changes and self-report measures were used to assess emotional changes. Misophonic cues elicited anger, disgust and sadness in patients compared to controls. Emotional changes were associated with increases in heart rate. The neuroimaging data revealed increased activation of the right insula, right anterior cingulate cortex and right superior temporal cortex during viewing of the misophonic video clips compared to neutral clips. Our results demonstrate that audiovisual stimuli trigger anger and physiological arousal in patients with misophonia, associated with activation of the auditory cortex and salience network.
Carbon content-tuned martensite transformation in low-alloy TRIP steels
Authors: Shen Y. F. , Dong X. X. , Song X. T. , Jia N. 
Published: May 2019

AbstractUltrahigh strength and good ductility are obtained for two low-alloy transformation-induced-plasticity steels fabricated by the quenching and partitioning (Q&P) processing, respectively. Compared to 0.19 wt.% C steel in which γ → α′-martensite transformation is the dominant mechanism under deformation, the relatively high C content of austenite in 0.47 wt.% C steel is responsible for the transformation from γ to ε-martensite, suggesting that the transformation is not solely determined by the stacking fault energy. The study shows that during the Q&P process, strong and ductile steels with specific transformation procedures can be obtained by adjusting volume fraction and carbon content of the retained austenite.
Wavelet compression of off-axis digital holograms using real/imaginary and amplitude/phase parts
Authors: Cheremkhin P. A. , Kurbatova E. A. 
Published: May 2019

AbstractCompression of digital holograms allows one to store, transmit, and reconstruct large sets of holographic data. There are many digital image compression methods, and usually wavelets are used for this task. However, many significant specialties exist for compression of digital holograms. As a result, it is preferential to use a set of methods that includes filtering, scalar and vector quantization, wavelet processing, etc. These methods in conjunction allow one to achieve an acceptable quality of reconstructed images and significant compression ratios. In this paper, wavelet compression of amplitude/phase and real/imaginary parts of the Fourier spectrum of filtered off-axis digital holograms is compared. The combination of frequency filtering, compression of the obtained spectral components, and extra compression of the wavelet decomposition coefficients by threshold processing and quantization is analyzed. Computer-generated and experimentally recorded digital holograms are compressed. The quality of the obtained reconstructed images is estimated. The results demonstrate the possibility of compression ratios of 380 using real/imaginary parts. Amplitude/phase compression allows ratios that are a factor of 2–4 lower for obtaining similar quality of reconstructed objects.
Role of theFusarium oxysporummetallothionein Mt1 in resistance to metal toxicity and virulence
Authors: Lorenzo-Gutiérrez Damaris , Gómez-Gil Lucía , Guarro Josep , Roncero M Isabel G , Fernández-Bravo Ana , Capilla Javier , López-Fernández Loida 
Published: May 2019

AbstractSoil organisms exhibit high tolerance to heavy metals, probably acquired through evolutionary adaptation to contaminated environments. Essentially, metal tolerance in fungi involves several specific and non-specific mechanisms that include metal efflux, metal binding to cell walls, extracellular and intracellular sequestration and complexation with proteins. However, fungi have adopted different strategies to detoxify heavy metals, although species differ in the mechanisms used. In this complex molecular framework, metallothioneins (MTs) are becoming increasingly relevant in metal homeostasis, even though little is known about their role in metal adaptation and virulence in fungal pathogens. With the aim to decipher the function of metallothioneins in the opportunistic fungus Fusarium oxysporum, we have carried out an in silico analysis that revealed the presence of a hypothetical metallothionein (mt1) that has multiple metal responsive elements in its promoter region and conserved cysteine motifs in its coding sequence. Characterization of strain Δmt1 deficient in the mt1 gene revealed higher sensitivity of this mutant to copper, cadmium and zinc compared to the wild type strain (wt). Expression analyses revealed that Zn specifically activates mt1, but the lack of this gene did not lead to a transcriptional up-regulation of genes gapdh and prx, associated with the oxidative stress response. The lack of mt1 did not alter the pathogenic capacity of the fungus, either in tomato plant or in a murine model of systemic infection. Nevertheless, Δmt1 displayed lower resistance to macrophage killing, suggesting a connection between the absence of mt1 and impaired defence capacity against copper and reactive oxygen species.
Biological enrichment prediction of polychlorinated biphenyls and novel molecular design based on 3D-QSAR/HQSAR associated with molecule docking
Authors: Yang Jiawen , Gu Wenwen , Li Yu 
Published: May 2019

Abstract
Based on the experimental data of octanol-water partition coefficients (Kow, represents bioaccumulation) for 13 polychlorinated biphenyl (PCB) congeners, comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were used to establish 3D-QSAR models, combined with the hologram quantitative structure–activity relationship (HQSAR), the substitution sites (mono-substituted and bis-substituted) and substituent groups (electron-withdrawing hydrophobic groups) that significantly affect the octanol-water partition coefficients values of PCBs were identified, a total of 63 monosubstituted and bis-substituted were identified. Compared with using 3D-QSAR model alone, the coupling of 3D-QSAR and HQSAR models greatly increased the number of newly designed bis-substituted molecules, and the logKow reduction in newly designed bis-substituted molecules was larger than that of monosubstituted molecules. This was established to predict the Kow values of 196 additional PCBs and carry out a modification of target molecular PCB-207 to lower its Kow (biological enrichment) significantly, simultaneously maintaining the flame retardancy and insulativity after calculation by using Gaussian09. Simultaneously, molecular docking could further screen out three more environmental friendly low biological enrichment newly designed PCB-207 molecules (5-methyl-PCB-207, 5-amino-PCB-207, and 4-amino-5-ethyl-PCB-207).
Silencing of junctional adhesion molecule-like protein attenuates atherogenesis and enhances plaque stability in ApoE−/− mice
Authors: Sun Yu , Guan Juan , Hou Yunfeng , Xue Fei , Huang Wei , Zhang Wencheng , Zhang Yun , Zhang Cheng , Yang Jianmin 
Published: May 2019

Abstract
Background: Although junctional adhesion molecule-like protein (JAML) has recently been implicated in leukocyte recruitment during inflammation and wound repair, its role in atherosclerosis remains to be elucidated.
Methods and results: First, we showed that JAML was strongly expressed in atherosclerotic plaques of cardiovascular patients. Similar results were obtained with atherosclerotic plaques of ApoE−/− mice. Co-immunofluorescence staining showed that JAML was mainly expressed in macrophages. Enhanced expression of JAML in cultured macrophages was observed following exposure of the cells to oxLDL. The functional role of JAML in atherosclerosis and macrophages function was assessed by interference of JAML with shRNA in vivo and siRNA in vitro. Silencing of JAML in mice significantly attenuated atherosclerotic lesion formation, reduced necrotic core area, increased plaque fibrous cap thickness, decreased macrophages content and inflammation. In addition, histological staining showed that JAML deficiency promoted plaques to stable phenotype. In vitro, JAML siRNA treatment lowered the expression of inflammatory cytokines in macrophages treated with oxLDL. The mechanism by which JAML mediated the inflammatory responses may be related to the ERK/NF-κB activation.
Conclusions: Our results demonstrated that therapeutic drugs which antagonize the function of JAML may be a potentially effective approach to attenuate atherogenesis and enhance plaque stability.
Band pass filter design against interrupted‐sampling repeater jamming based on time‐frequency analysis
Authors: Chen Jian , Wu Wenzhen , Xu Shiyou , Chen Zengping , Zou Jiangwei 
Published: May 2019

The interrupted‐sampling repeater jamming (ISRJ) is coherent with an emitted signal, and significantly limits radar's ability to detect, track and recognise targets. This study focuses on the research of ISRJ suppression for linear frequency modulation radars. A new band pass filter design method based on time frequency (TF) analysis is proposed. A function named ‘max‐TF’ is constructed from the TF energy distribution of the de‐chirped signal, reflecting the changes of the maximum signal component amplitude with respect to time. Based on the ‘max‐TF’ function, jamming‐free signal segments are automatically and accurately extracted to generate the filter, which is smoothed subsequently. After filtering, jamming signal peaks in pulse compression results are suppressed while real targets are retained simultaneously. Comparing with the state‐of‐the‐art filtering method, the proposed method has improved jamming suppression ability and extended the feasible scope of signal‐to‐noise ratio and jamming‐to‐signal ratio conditions. Simulations have validated the improvements and demonstrated how the parameters affect performance. The average signal to jamming improvement and average radar detection rate of the proposed method is about 7.4 dB and 23% higher than those of the state‐of‐the‐art filtering method, respectively. The direction of further works is inferred.
Dynamic field line draping at comet 67P/Churyumov-Gerasimenko during the Rosetta dayside excursion
Authors: Volwerk Martin , Goetz Charlotte , Behar Etienne , Delva Magda , Edberg Niklas J. T. , Eriksson Anders , Henri Pierre , Llera Kristie , Nilsson Hans , Richter Ingo , Stenberg Wieser Gabriella , Glassmeier Karl-Heinz 
Published: May 2019

Context. The Rosetta dayside excursion took place in September–October 2015 when comet 67P/Churyumov-Gerasimenko (67P/CG) was located at ~1.36 AU from the Sun after it had passed perihelion on 13 August 2015 at ~1.25 AU. At this time, the comet was near its most active period, and its interaction with the solar wind was expected to be at its most intense, with ion pickup and magnetic field line draping. The dayside excursion was planned to move through different regions that were expected upstream of the cometary nucleus, and to possibly detect the location of the bow shock.
Aims. The goal of this study is to describe the dynamic field line draping that takes place around the comet and the plasma processes that are connected to this.
Methods. The data from the full Rosetta Plasma Consortium (RPC) were used to investigate the interaction of solar wind and comet, starting from boxcar-averaged magnetic field data in order to suppress high-frequency noise in the data. Through calculating the cone and clock angle of the magnetic field, we determined the draping pattern of the magnetic field around the nucleus of the comet. Then we studied the particle data in relation to the variations that are observed in the magnetic field.
Results. During the dayside excursion, the magnetic field cone angle changed several times, which means that the magnetic field direction changes from pointing sunward to anti-sunward. This is caused by the changing directions of the interplanetary magnetic field that is transported toward the comet. The cone-angle direction shows that mass-loading of the interplanetary magnetic field of the solar wind leads to dynamic draping. The ion velocity and the magnetic field strength are correlated because the unmagnetized ions are accelerated more (less) strongly by the increasing (decreasing) magnetic field strength. There is an indication of an anticorrelation between the electron density and the magnetic field strength, which might be caused by the magnetized electrons being mirrored out of the strong field regions. The Rosetta RPC has shown that (dynamic) draping also occurs as mildly active comets, as was found at highly active comets such as 1P/Halley and 21P/Giacobini-Zinner, but also that determining both dynamic and nested draping will require a combination of fast flybys and slow excursions for future missions.
Jetlag, schlaflos auf und nach Reisen – bewährte Indikationen
Authors: Bleul Gerhard 
Published: May 2019

ZusammenfassungHomöopathische Differenzialdiagnose von Schlafstörungen im Zusammenhang mit Reisen. Schnelle Mittelwahl aufgrund der psychischen Hintergründe, besonderer Charakteristika und Modalitäten.
Fünf Fälle enttarnt: nicht-muskuloskelettal
Authors: Knorr Hansjörg 
Published: May 2019

ZusammenfassungBei manchen Patienten ist echte Detektivarbeit notwendig, um zur richtigen
Diagnose zu gelangen. Neuromuskuloskelettale Symptome können unter anderem auch
bei viszeralen Erkrankungen auftreten und so Therapeuten auf die falsche Fährte
locken. Interdisziplinäres Arbeiten ist gefragt, um in diesen Fällen dennoch auf
die richtige Spur zu kommen. Dr. Hansjörg Knorr zeigt an fünf Fallbeispielen,
wie dies gelingen kann.
Roboterassistierte Resektion einer retrorektalen Tailgut-Zyste – erstbeschreibender Videofallbericht einer 27-jährigen Patientin
Authors: Wilhelm Peter , Jansen Kai , Rolinger Jens , Kirschniak Andreas , Axt Steffen , Johannink Jonas 
Published: May 2019

Zusammenfassung
Zielsetzung Tailgut-Zysten stellen eine seltene Form perirektaler Raumforderungen dar. Es handelt sich dabei um zystische Hamartome mit zumeist retrorektaler Manifestation und weiblicher Prädominanz. Das maligne Entartungsrisiko ist unzureichend evaluiert und wird mit etwa 2 – 10% angegeben. Unabhängig vom Malignitätsrisiko besteht die Gefahr für Komplikationen durch Infektion, Fistelbildung, Defäkationsstörungen und Dystokie, sodass die Indikation zur vollständigen Resektion gegeben ist.
Indikationen Wir beschreiben den Fall einer 27-jährigen Patientin mit intermittierendem Prolabieren einer rundlichen Struktur bei Defäkation. Der MR-morphologischen und endosonografischen Abklärung folgte die histologische Sicherung mittels endoskopischer transrektaler Drainage und roboterassistierter minimalinvasiver Zystenentfernung im Verlauf. Nach Kenntnisstand der Autoren ist dieser Zugangsweg bislang nicht beschrieben in der Resektion von Tailgut-Zysten.
Methode Unser Video zeigt die präoperativen Befunde einschließlich der funktionellen Diagnostik, die Durchführung der endoskopischen Histologiegewinnung sowie die Technik der roboterassistierten retrorektalen Zystenresektion. Dabei präsentierte sich intraoperativ eine Vollwandläsion der hinteren Rektumwand im Bereich der ehemaligen Punktionsstelle, die sich komplikationslos übernähen ließ.
Schlussfolgerung Verschiedene Zugangswege sind für die Tailgut-Zysten-Resektion beschrieben. Die weiteste Verbreitung ist für den posterioren/sakralen Zugang dokumentiert. Weitere etablierte Techniken sind die abdominale und transrektale Resektion. Eine abdominale roboterassistierte Zystenresektion ist nicht vorbeschrieben. Aufgrund der umfangreichen Erfahrung mit der roboterassistierten minimalinvasiven Chirurgie im kleinen Becken wählten wir die hier erstbeschriebene Vorgehensweise.
Testsequenzen für den Praktiker
Authors: Schulze Elke , Kubat Heike 
Published: May 2019

ZusammenfassungBei zervikalen Dysfunktionen in Verbindung mit Schwindel stellen Lagerungstests
einen wichtigen Bestandteil der Manuellen Therapie dar. Dieser 1. Teil der
Artikelreihe zu Tests bei kraniozervikalen Nacken-, Kopf- und Gesichtsschmerz
oder Schwindel erklärt die Anwendung und den Nutzen der Tests beim posterioren
benignen paroxysmalen Lagerungsschwindel (p-BPLS).Der Dix-Hallpike-Test oder der Semont-Test ermöglichen eine relativ zuverlässige
Differenzierung des einseitigen p-BPLS, der sich effektiv mit einem
Befreiungsmanöver behandeln lässt.
A Cut-off Value for Gestational Week at Birth for Better Perinatal Outcomes in Early- and Late-Onset Fetal Growth Restriction
Authors: Beksac Mehmet Sinan , Fadiloglu Erdem , Tanacan Atakan , Mamopoulos Apostolos , Basol Merve , Muresan Daniel , Athanasiadis Apostolos 
Published: May 2019

Abstract
Objective Prediction of cut-off value for gestational week at birth for better perinatal outcomes in early- and late-onset fetal growth restriction (FGR).
Materials and Methods This study consists of 83 singleton pregnancies with FGR that were diagnosed antenatally and confirmed postnatally between January 2017–April 2018. We used the 34th gestational week as a cut-off for early- and late-onset FGR discrimination.
Results Early- and late-onset FGRs were detected in 22 (26.5%) and 61 (73.5%) of the cases, respectively. Expectant management significantly improved birth weight and Apgar scores at the 1st, 5th, and 10th minute in early-onset FGR cases (p=0.001, p=0.019, p=0.002, and p=0.001,respectively). Similar analysis revealed no significant improvements in late-onset FGR (p=0.151, p=0.727, p=0.951 and p=0.477, respectively). Umbilical cord blood gas pH was found to be similar between management modalities in both the early- and late-onset groups (p=0.186 and p=0.456, respectively). Gestational week 33.5 was found to be the threshold for better Apgar scores at the 1st, 5th, and 10th minute according to ROC curve analysis. Percentiles of 4.5, 2.5, and 4.5 were cut-off values for better Apgar scores at the 1st, 5th, and 10th minute, respectively.
Conclusion Expectant management must be the first choice to improve Apgar scores in early-onset FGR cases, and gestational week 33.5 must be considered as a threshold for delivery. Immediate delivery might be the choice in late-onset FGR in necessary cases. However, etiology-based management and perinatal surveillance might also be considered to improve prematurity-related neonatal complications.
Return to Work aus einer zeitlich befristeten Erwerbsminderungsrente
Authors: Köckerling Elena , Sauzet Odile , Hesse Bettina , Körner Michael , Razum Oliver 
Published: May 2019

Zusammenfassung
Ziel der Studie Zurzeit wird in Deutschland keine Statistik darüber geführt, wie viele Personen mit einer zeitlich befristeten Erwerbsminderungsrente (EM-Rente) ein Return to Work (RTW) realisieren. Ziel dieser Studie ist es zu prüfen, wie viele Personen, die 2006 zum ersten Mal eine zeitlich befristete EM-Rente erhalten haben, ein RTW erreichten und welche soziodemografischen, gesundheitlichen und beruflichen Merkmale diese Personen aufweisen.
Methodik Der Scientific Use File „Abgeschlossene Rehabilitation 2006–2013 im Versicherungsverlauf“ des Forschungsdatenzentrums der Deutschen Rentenversicherung wurde ausgewertet. Als RTW wurde gewertet, wenn eine Person nach Berentung in einem der 7 Folgejahre an 183–365 Tagen mindestens einer Halbtagsbeschäftigung nachging und dafür wenigstens 8,50 Euro/Stunde erhielt. Die Entwicklungen der Kohorte wurden deskriptiv ausgewertet. Der Zusammenhang von soziodemografischen, gesundheitlichen und beruflichen Merkmalen der Personen und dem RTW wurde durch Cox-Regressionen ermittelt.
Ergebnisse Von der Ausgangskohorte (N=9.789) erreichten in dem Beobachtungszeitraum 5,9% ein RTW. Von diesen erreichten ca. 25% ein RTW in jedem Folgejahr. Im Beobachtungszeitraum verstarben 10,6%, 9,1% gingen in Altersrente und 1,4% erhielten eine unbefristete EM-Rente. Die Regressionsanalyse zeigt, dass soziodemografische, gesundheitliche und berufliche Merkmale der EM-Rentner/innen in signifikantem Zusammenhang mit einem RTW stehen: EM-Rentner/innen im Alter von 18–39 Jahren, mit einer somatischen Rentenbewilligungsdiagnose, einer medizinischen Rehabilitation oder einer Erwerbstätigkeit vor der EM-Rente haben die höchste Wahrscheinlichkeit auf ein RTW.
Schlussfolgerung Die Ergebnisse zeigen, dass nur wenige Personen ein RTW aus der EM-Rente erreichen. Es könnte einerseits geschlussfolgert werden, dass die Kriterien für eine zeitliche Befristung von EM-Renten geschärft werden sollten, um dadurch z. B. den Arbeitsaufwand für Wiederbegutachtungen zu verringern. Andererseits könnte auch ein deutlicher Unterstützungsbedarf der EM-Rentner/innen bei der Realisierung eines RTW und ein dafür notwendiger Forschungsbedarf postuliert werden.
Stationäre Diabetestherapie und Behandlung
Authors: Fritsche Andreas 
Published: May 2019

ZusammenfassungIn der Gesellschaft und Politik wird Diabetes mellitus oftmals noch als eine Krankheit angesehen, die leicht ambulant zu behandeln ist und nur selten eine stationäre Therapie erfordert. In Wahrheit ist jedoch jeder 4. stationär behandelte Patient an Diabetes erkrankt. Auch die Mortalität von Diabetes wurde bisher weit unterschätzt. Angesichts der demographischen Entwicklung und Zunahme der Diabetesprävalenz, der gleichzeitig sinkenden Anzahl von Diabetesabteilungen in den Krankenhäusern und der schlechten Abbildung von Diabetes im Vergütungssystem in den Krankenhäusern kommt ein großes Problem auf das Gesundheitssystem zu. Dieser Artikel zeigt die Notwendigkeit einer stationären Diabetologie auf und gibt Anregungen zur Behandlung und Forschung von Diabetes im Krankenhaus.
Biomechanical Comparison of Three Crural Fascia Repair Techniques for Tibial Tuberosity Advancement Surgery
Authors: Giangarra Jenna , Lanz Otto , Glennon Joseph , Kobayashi Takayuki , Tarkanian Michael , Tepic Slobodan , Werre Stephen 
Published: May 2019

Objectives The aim of this study was to compare the strength of three described techniques for repair of the medial crural fascia to the strength of the intact fascia of the paired limbs. We hypothesized that intact controls would have higher peak loads at failure than repair groups and that the modified Mason–Allen suture pattern would have the highest peak load at failure of the repair groups.
Materials and Methods Canine cadavers (n = 22) were randomly assorted into three groups. Group A: a continuous suture pattern. Group B: five equally spaced simple interrupted cruciate sutures over a simple continuous suture pattern. Group C: an interrupted modified Mason–Allen suture pattern. The mid-portion of the crural fascia was incised in Groups A and C, while Group B used a cranial incision. Contralateral limbs were utilized as paired controls. Tibiae were mounted to a biomaterial testing machine and the medial crural fascia loaded at 10 mm/min.
Results Mean peak load to failure for Group A: 201.0N, Group B: 261.0N, Group C: 306.1N and Intact limbs: 799.5N. Between repair groups, there was no significant difference between peak loads to failure identified. Significant differences were identified between all repairs and intact limbs. All repairs approached a mean of 33.5% (267.8N) of intact medial crural fascia strength.
Clinical Significance All repair techniques met no more than 1/3 intact medial crural fascia strength. Further research is required to continue to evaluate the most clinically appropriate technique to repair the medial tibial crural fascia.