bluuebunny/crossref_metadata_2025_split huggingface dataset:
Odontologia hospitalar nos hospitais de grande porte da região metropolitana da Grande Vitória, Espírito Santo
Authors: Gonçalves Camila Lopes , Silva Junior Manoelito Ferreira , Andrade Lezimara Santiago de , Miclos Paula Vitali , Gomes Maria José 
Published: August 2019

Unidade hospitalar de Odontologia; Equipe hospitalar de Odontologia; Comunicação interdisciplinar; Área de atuação profissional.
Hypomagnesemia in Obese Subjects: Evidence of Systematic Review and Meta-analysis
Authors: Cruz Kyria J.C. , de Oliveira Ana R.S. , de Freitas Suelem T. , Henriques Gilberto S. , do Nascimento Marreiro Dilina 
Published: August 2019

Background::
Magnesium deficiency is a global nutritional problem which seems to influence
obesity-associated metabolic disorders because magnesium plays an important role in the prevention
and treatment of many diseases.

Objective::
We conducted a systematic review and meta-analysis to evaluate the relationship between
plasma magnesium concentrations and obesity.

Methods::
A systematic review and meta-analysis of case-control studies was conducted. Relevant
studies were identified from a literature search using electronic databases.

Results::
Ten case-control studies were evaluated in this meta-analysis. Results demonstrated that
obese individuals presented lower plasma magnesium concentration than healthy individuals (standardized
mean difference [SMD] = -0.44, 95% confidence interval = -0.88 to -0.01). In subgroup
analyses, there were differences in plasma magnesium concentration between obese and healthy individuals
according to study location, gender, case age, control age, method for assessment of magnesium
concentration and study quality. Furthermore, meta-regression analyses showed that the
source of heterogeneity of magnesium levels among studies was control age.

Conclusion::
Evidence of this systematic review and meta-analysis show hypomagnesemia in obese
individuals of both genders.
Heart Failure and Cognitive Impairment: Clinical Relevance and Therapeutic Considerations
Authors: Mene-Afejuku Tuoyo O. , Pernia Monica , Ibebuogu Uzoma N. , Chaudhari Shobhana , Mushiyev Savi , Visco Ferdinand , Pekler Gerald 
Published: August 2019

:Heart failure (HF) is a devastating condition characterized by poor quality of life, numerous complications, high rate of readmission and increased mortality. HF is the most common cause of hospitalization in the United States especially among people over the age of 64 years. The number of people grappling with the ill effects of HF is on the rise as the number of people living to an old age is also on the increase.:Several factors have been attributed to these high readmission and mortality rates among which are; poor adherence with therapy, inability to keep up with clinic appointments and even failure to recognize early symptoms of HF deterioration which may be a result of cognitive impairment.:Therefore, this review seeks to compile the most recent information about the links between HF and dementia or cognitive impairment. We also assessed the prognostic consequences of cognitive impairment complicating HF, therapeutic strategies among patients with HF and focus on future areas of research that would reduce the prevalence of cognitive impairment, reduce its severity and also ameliorate the effect of cognitive impairment coexisting with HF.
Correlation between Antioxidant/Antimutagenic and Antiproliferative Activity of Some Phytochemicals
Authors: Ramadan Doaa T. , Ali Mohamed A.M. , Yahya Shaymaa M. , El-Sayed Wael M. 
Published: August 2019

Background:
Chemotherapeutic drugs have high toxicity associated with undesirable side-effects. Now,
natural products are the most important anti-cancer agents because of their low toxicity and potential effectiveness.

Methods:
The half maximal inhibitory concentration (IC50) of amygdalin, naringenin and ellagic acid against
breast, colon, and liver cell lines was estimated. The antimutagenic, free radical-, superoxide radical-, and hydroxyl
radical- scavenging activities of these phytochemicals were measured. The expression of p53, bid, bax,
bcl2, and caspases 9, 3, and 7 was measured by quantitative real-time polymerase chain reaction (qRT-PCR) in
breast and liver cells. In addition, the active Caspase 3 protein was estimated in liver cells.

Results:
Ellagic acid showed the highest antioxidant and antiproliferative activities. Amygdalin and naringenin
with low and moderate antioxidant profiles showed a corresponding low and moderate cytotoxicity against
cancer cell lines, respectively. Naringenin and ellagic acid had a significant antimutagenic activity which was
detected by the Salmonella test. Ellagic acid offered a much better antimutagenic activity than naringenin. The
apoptotic pathway evoked by ellagic acid in HepG2 and MCF-7 cells was investigated. The results showed that
a caspase-dependent and a caspase-independent apoptosis occurred in MCF-7 and HepG2, respectively.

Conclusion:
The antimutagenic/antioxidant properties are well correlated with the antiproliferative activity of
the phytochemicals investigated. This study proved that some easy, quick and cheap assays could predict the
antiproliferative activity of many nutraceuticals. Finally, this platform could help in the discovery of new anticancer
agents where hundreds of compounds are investigated in the pipeline of drug discovery.
Evaluation of Pb (II) Adsorption from Aqueous Solutions Using Brassica nigra as a Biosorbent
Authors: Reátegui-Romero Warren , Cadenas-Vásquez Walter J. , King-Santos María E. , Alvarez Walter F. Zaldivar , Posadas Ricardo A. Y. 
Published: August 2019

Objectives:The Pb non-biodegradability results in bioaccumulation in living organisms causing serious health disorders. The present study aimed to investigate the capacity of Pb (II) adsorption in aqueous solutions using theBrassica nigraspecies as biosorbent.Methods:The present study was conducted using a synthetic solution with three Pb (II) concentrations (5, 15, and 30 ppm). TheB. nigrawas suitably treated until it became dry particles. After sifting it, three ranges of grain sizes were obtained. Samples of dry particles were analyzed before and after the biosorption to analyze their topography (SEM), as well as the elements on their surface (EDS). The influence of different operating variables on the biosorption of Pb (II) were analyzed. Kinetics of Pb (II) biosorption was analyzed with pseudo first and second order models. The biosorption in the equilibrium was studied with the Langmuir isotherm and Freundlich isotherm models.Results:The biosorbentB. nigrashowed to be efficient for the adsorption of Pb (II). The most influential variables in the adsorption were pH, particle size, and biosorbent/solution ratio. The optimum pH for the adsorption of lead was 5 and removed 82.10% of lead from solution at 5 ppm, 82.24% at 15 ppm and 57.95% at 30 ppm. The results for the particle size between 177 and 297 μm were 82.65% for 5 ppm, 73.71% for 15 ppm, and 53.54% for 30 ppm. The biosorbent/solution ratio of 0.6 mg/mL or the 30 mg dose of biosorbent removed 80.26% for 5 ppm, 79.32% for 15 ppm, and 59.87% for 30 ppm. Biosorption isothermal data could be well interpreted by the Langmuir model with a maximum adsorption capacity of 53.476 mg/g of lead ion onB. nigrastem and roots biomass. The kinetic experimental data was properly correlated with the second-order kinetic model (R2= 0.9997). Thus, the best desorbing agent was HNO3(0.1N) for Pb (II) desorption.Conclusion:Our study showed that the herbB. nigra, without any chemical treatment, can be used to remove heavy metals such as Pb (II) from water and aqueous solution.
Evaluation of the Anti-Tumor Activity of Niclosamide Nanoliposomes Against Colon Carcinoma
Authors: Hatamipour Mahdi , Jaafari Mahmoud R. , Momtazi-Borojeni Amir A. , Ramezani Mahin , Sahebkar Amirhossein 
Published: August 2019

Background and Aims:
Niclosamide is an established anti-helminthic drug, which has recently
been shown to inhibit the growth of various cancer cells. To exploit the potential anti-tumor activity
of this drug for systemic use, the problem of low aqueous solubility should be addressed. The
present study tested the in vivo anti-tumor effects of a recently developed nanoliposomal preparation of
niclosamide in an experimental model of colon carcinoma.

Methods :
The cytotoxicity of nanoliposomal niclosamide on CT26 colon carcinoma cells was evaluated
using the MTT test. Inhibition of tumor growth was investigated in BALB/c mice bearing CT26 colon
carcinoma cells. The animals were randomly divided into 4 groups including: 1) untreated control, 2)
liposomal doxorubicin (15 mg/kg; single intravenous dose), 3) liposomal niclosamide (1 mg/kg/twice a
week; intravenously for 4 weeks), and 4) free niclosamide (1 mg/kg/twice a week; intravenously for 4
weeks). To study therapeutic efficacy, tumor size and survival were monitored in 2-day intervals for 40
days.

Results:
In vitro results indicated that nanoliposomal and free niclosamide could exert cytotoxic effects
with IC50 values of 4.5 and 2.5 μM, respectively. According to in vivo studies, nanoliposomal niclosamide
showed a higher growth inhibitory activity against CT26 colon carcinoma cells compared
with free niclosamide as revealed by delayed tumor growth and prolongation of survival.

Conclusion :
Nnaoliposomal encapsulation enhanced anti-tumor properties of niclosamide in an experimental
model of colon carcinoma.
Home Virtual Visits for Outpatient Follow-Up Stroke Care: Cross-Sectional Study
Authors: Appireddy Ramana , Khan Sana , Leaver Chad , Martin Cally , Jin Albert , Durafourt Bryce A , Archer Stephen L 
Published: August 2019

Background
Timely, in-person access to health care is a challenge for people living with conditions such as stroke that result in frailty, loss of independence, restrictions in driving and mobility, and physical and cognitive decline. In Southeastern Ontario, access is further complicated by rurality and the long travel distances to visit physician clinics. There is a need to make health care more accessible and convenient. Home virtual visits (electronic visits, eVisits) can conveniently connect physicians to patients. Physicians use a secure personal videoconferencing tool to connect to patients in their homes. Patients use their device of choice (smartphone, tablet, laptop, or desktop) for the visit.

Objective
This study aimed to assess the feasibility and logistics of implementing eVisits in a stroke prevention clinic for seniors.

Methods
A 6-month eVisit pilot study was initiated in the Kingston Health Sciences Centre stroke prevention clinic in August 2018. eVisits were used only for follow-up patient encounters. An integrated evaluation was used to test the impact of the program on clinic workflow and patient satisfaction. Patient satisfaction was evaluated by telephone interviews, using a brief questionnaire. Access and patient satisfaction metrics were compared with concurrent standard of care (patients’ prior personal experience with in-person visits). Values are presented as median (interquartile range).

Results
There were 75 subjects in the pilot. The patients were aged 65 (56-73.5) years, and 39% (29/75) resided in rural areas. There was a shorter wait for an appointment by eVisit versus in-person (mean 59.98 [SD 48.36] days vs mean 78.36 [SD 50.54] days; P<.001). The eVisit was also shorter, taking on an average of only 10 min to deliver follow-up care with a high degree of patient satisfaction versus 90 (60-112) min for in-person care. The total time saved by patients per eVisit was 80 (50-102) min, 44 (21-69) min of which was travel time. Travel distance avoided by the patients was 30.1 km (11.2-82.2). The estimated total out-of-pocket cost savings for patients per eVisit was Can $52.83 (31.26-94.53). The estimated savings (opportunity cost for in-person outpatient care) for our eVisit pilot project was Can $23,832-$28,584. The patient satisfaction with eVisits was very good compared with their prior personal experience with in-person outpatient care.

Conclusions
The eVisit program was well received by patients, deemed to be safe by physicians, and avoided unnecessary patient travel and expense. It also has the potential to reduce health care costs. We plan to scale the project within the department and the institution.
Incremental direct healthcare expenditures of valvular heart disease in the USA
Authors: Mallow Peter J , Chen Jie , Moore Matt , Gunnarsson Candace , Rizzo John A 
Published: August 2019

Aim:
To quantify the healthcare expenditures for valvular heart disease (VHD) in the USA.
Patients & methods:
Direct annual incremental healthcare expenditures were estimated using multiple logistic and linear regression models. Results were stratified by age cohorts (18–64 years, ≥65 and ≥75 years) and disease status: symptomatic aortic valve disease (AVD), asymptomatic AVD, symptomatic mitral valve disease (MVD) and asymptomatic MVD.
Results:
A total of 1463 VHD patients were identified. The overall aggregated incremental direct expenditures were $56.62 billion ($26.48 billion for patients ≥75 years). Individuals ≥75 years with symptomatic AVD had the largest incremental effect on annual, per-patient healthcare expenditure of $30,949. The annualized incremental costs of VHD were greatest for individuals ≥75 years with AVD.
Conclusion:
Identification of VHD at an earlier stage may reduce the economic burden.
Eficiencia y productividad en las unidades de transferencia de resultados de investigación científica en México
Authors: Yeverino Juárez Jorge Antonio , Montoro Sánchez María Ángeles 
Published: August 2019

El objetivo de este trabajo es evaluar y determinar los niveles de eficiencia y productividad entre las unidades académicas involucradas en la transferencia tecnológica universitaria en México. La investigación empírica se basa en la encuesta aplicada a 21 centros de investigación y educación superior en México. Se diseñaron dos modelos complementarios: un modelo de programación lineal de envolvimiento de datos (método no paramétrico tipo DEA) y un modelo estocástico de frontera (método paramétrico tipo SFE). Los resultados muestran una homogeneidad relativa en las instituciones de educación superior y centros públicos de investigación que participan desde 2011 en procesos de transferencia tecnológica en México. Sin embargo, en contraste con otros países más desarrollados, la productividad en factores como número e ingresos por licencias, número de notificaciones de invenciones y experiencia de las oficinas de transferencia tecnológica es muy limitada. Estos resultados sugieren que la eficiencia técnica ha permanecido estable en períodos cortos de tiempo.
Fácies e paleoambientes em uma sucessão estratigráfica da porção central do Complexo Deltaico do Rio Paraíba do Sul (RJ, Brasil)
Authors: PLANTZ Josiane Branco , CARELLI Thiago Gonçalves , BORGHI Leonardo , CARVALHO Marcelo De Araújo , RAMOS Renato Rodriguez Cabral 
Published: August 2019

O Complexo Deltaico do Rio Paraíba do Sul (CDRPS), localizado no litoral norte do Estado do Rio de Janeiro, é uma importante planície costeira de idade quaternária que engloba parte da porção emersa da Bacia de Campos. Embora seja alvo de estudos sedimentológicos e estratigráficos desde a década de 1940, os estudos envolvendo amostragens de subsuperfície contínuas e de alcance profundo são recentes e pouco numerosos. Com base nisto, o presente trabalho busca contribuir através de informações litológicas, faciológicas e paleoambientais advindas da testemunhagem contínua do poço 2-TO-1-RJ (181 m) e subsidiar discussões acerca da evolução do CDRPS. Análises de difração de raios-X (DRX) em argilominerais, carbono orgânico total (COT) e palinofácies foram realizadas para a caracterização dos paleoambientes deposicionais. Datações por radiocarbono foram importantes para a correlação com os modelos evolutivos existentes. Com o apoio de descrições petrográficas, foram identificadas 12 fácies sedimentares, dentre as quais uma rudítica (Ccm), cinco areníticas (ACm, Am, Amf, Ae e ALm), uma heterolítica (IF), duas híbridas (Ab e Lh) e três lutíticas (Lm, Ll e LAm), agrupadas em sete sucessões de fácies (SF-LA, SF-F1, SF-Dc, SF-M, SF-F2, SF-Lg e SF-F3), indicativas de diferentes estágios de sedimentação. Os resultados apontam para uma sedimentação basal típica de porções medianas a distais de leques aluviais sucedida por deposição em ambiente fluvial, ambos atribuídos ao Membro São Tomé (Formação Emborê). Estes depósitos foram parcialmente erodidos pela escavação de um vale inciso, preenchido por depósitos transgressivos estuarinos e marinhos, de idade pleistocênica (mais antigos que 40.000 anos AP). O registro holocênico é restrito aos primeiros 13,40 m do testemunho e sugere a instalação de uma paleolaguna, posteriormente colmatada por um sistema fluvial.
É ISTO UM CONTO? TRADIÇÃO E INOVAÇÃO NO CONTISTA JORGE LUIS BORGES
Authors: Silva Lucilene Conceição Silveira 
Published: August 2019

O presente trabalho tem como objetivo estudar a inovação estética de Jorge Luis Borges como contista sugerida pelo escritor sul-africano J. M. Coetzee em texto a respeito do argentino. A partir de um pequeno estudo da história desse gênero literário, com foco em Edgar Allan Poe, Tchekhov e Franz Kafka, chegaremos à análise de um dos contos mais emblemáticos de Borges “Tlön, Uqbar, Orbis Tertius” a fim de verificarmos a relação entre a tradição e a inovação nos contos borgianos.
O DISTANCIAMENTO ENTRE MATÉRIA NARRADA E POSIÇÃO DO NARRADOR NOS CONTOS DE BELAZARTE
Authors: Cardoso Gabriela Mattos 
Published: August 2019

Neste artigo, mostramos o descompasso entre o narrador d’Os contos de Belazarte, de Mário de Andrade, publicado em 1934, e o que ele narra. Para isso, trabalhamos com a origem do narrador (nas histórias de Pedro Malasartes), com os problemas do conjunto e com a história de São Paulo intrincada na narrativa. Nosso objetivo foi analisar os diversos traços de determinados contos que mostram a diferença entre a posição do narrador e as marcas textuais (como as falas das personagens, por exemplo).
A SEMÂNTICA DE MICHEL BRÉAL: UMA ABORDAGEM BASEADA NO USO
Authors: Sipavicius Seide Márcia 
Published: August 2019

Este artigo tem por objetivo mostrar que algumas das propostas apresentadas por Michel Bréal em seu Ensaio de Semântica (1992 [1904]) podem ser utilizadas em análises pragmático-cogtinitivas do uso linguístico. Apresentada uma breve revisão da literatura recente sobre o estudioso (2002 a 2012), suas propostas são descritas sob o viés pragmático de Nerlich e Clarke (1996). Após uma descrição ainda mais minuciosa dos insights pragmáticos do ensaio, uma análise de usos da conjunção “como” em textos oficiais paranaenses setecentistas e oitocentistas mostra a aplicabilidade deste modelo teórico.
REFLEXÕES ACERCA DO CONCEITO DE LÍNGUA COMO UMA INSTITUIÇÃO SOCIAL EM WILLIAM DWIGHT WHITNEY
Authors: Marra Daniel , Milani Sebastião Elias 
Published: August 2019

Trata-se, neste artigo, do conceito de língua como uma instituição social tributário a William Dwight Whitney (1827-1894). O pensamento deste sobre a natureza da língua representou um ponto de virada nos estudos da linguagem. Ao postular que a língua é uma instituição social, Whitney, contrariando teorias inatistas, insistiu que ela é uma criação humana como todas as outras instituições sociais. Esta seria a razão pela qual a língua sofre mudanças constantes. Mudanças que surgiriamprimeiramente nos falantes de uma língua, na forma de eles refletirem sobre si como indivíduos e como membros de uma sociedade. Dois processos relacionados estariam envolvidos: a mudança dos falantes causaria mudança na língua; a língua mudaria e essa mudança refletiria uma mudança nos falantes.
MEMÓRIA, TRADIÇÃO E IDENTIDADE EM "CRÔNICA DA CASA ASSASSINADA"
Authors: Garcia Neiva Kampff 
Published: August 2019

Crônica da casa assassinada, de Lúcio Cardoso, é uma narrativa de desestruturação do indivíduo e de decadência familiar, relatadas em fluxos de consciência de narradores e personagens. A espinha dorsal da obra relaciona a (des)construção de memórias, tradições e a busca de identidades numa sociedade em rápida transformação através do confronto de valores morais, sociais e econômicos. As reminiscências e as atualizações do passado remetem a um jogo constante de diferentes pontos de vista, em que afloram diversas perspectivas conforme a voz narrativa condutora. A intensidade e a dramaticidade presentes na obra traduzem múltiplos desequilíbrios psíquicos, degradações individuais de personagens que acabam por retratar o processo de deteorização de uma família.
RACISME, LES FEMMES
Authors: OZA Bijal 
Published: August 2019

Quand je suis née,
J’étais simplement un bébé.

Qui ne savait pas sa caste ;
Mais connaissait sourire.
Qui ne savait sa couleur de peau ;
Mais aimait toutes les couleurs.
Qui ne savait pas sa religion ;
Mais avait l’innocence donnée par Dieu.
Qui ne savait pas sa nationalité ;
Mais saluait l’humanité.
Linguagem Religiosa: constituição, tensividade, evento | Religious language: Constitution, tensivity, event
Authors: Zabatiero Júlio Paulo Tavares Mantovani 
Published: August 2019

Este artigo discute a natureza da linguagem religiosa a partir das refl exões sobre a linguagem no campo das Ciências das Religiões no Brasil, em diálogo com os estudos franceses sobre o discurso e a semiótica. Questionando a tradicional distinção entre linguagem científi ca e linguagem religiosa, o artigo defende a hipótese de que esta última pode ser melhor compreendida enquanto “discurso constituinte”, de modo que suas diferenças e similaridades com os demais tipos de discurso constituinte são destacadas. A partir dessa revisão da conceituação da linguagem religiosa, enfi m, o artigo discute a noção metafísica do sagrado e sua compreensão como o fundamento da Religião e apresenta a hipótese adicional de que é o “evento” que serve como archéion do discurso constituinte religioso. A partir dessas hipóteses defende-se uma noção de linguagem religiosa que pretende escapar do binarismo a que está submetida parte da discussão acadêmica sobre a Religião e sua Linguagem.
Family Quality of Life Among Families with a Member Diagnosed with CLD – What to Expect?
Authors: Rusu Adina , Rusu Ionuţ-Ovidiu , Călinoiu Amalia Loredana , Brîndușe Lăcrămioara Aurelia , Mincă Dana Galieta 
Published: August 2019

Abstract

Background and objectives. Health-related quality of life (HRQoL) is a very important outcome in patients with chronic liver disease. Thus, the present study attempts to assess the family quality of life of these patients, since it is well known that families have always represented the primary environment of most people.

Matherial and methods. A sample of 30 participants with a family member who had CLD were recruited to be interviewed through the Romanian adaptation of the Family Quality of Life Survey – general version 2006 (FQOLS-2006), an evaluation tool developed in Canada with the purpose of studying families’ quality of life among. Primary caregivers completed the FQOL Survey. The data was analysed to describe population characteristics and to explore the relationship between the main domains and dimensions of QoL and the patients and caregivers characteristics.

Results. The findings showed highest domain scores for Support from services and Family relationships and lowest for Support from others. Dimension scores were highest for Importance and lowest for Stability. Overall FQOL approximated average (78.5±13.4). Younger patients scored lower rates of FQOL domains. Alcohol-related liver disease led to lower rates of all the domains, except from Support from others and Leisure and Recreation activities. Patients with liver cirrhosis or liver cancer negatively influence their caregiver’s success in career. Also, families of liver cirrhosis patients reported the lowest level of satisfaction among all respondents.

Conclusions. The results of this study suggest that there are some significant areas of family life highly influenced by a chronic liver disease diagnosis in one of their members.