bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Cr Substitution and Temperature on Hierarchical Phase Decomposition in the AlCoFeNi High Entropy Alloy
Authors: Chaudhary V. , Gwalani B. , Soni V. , Ramanujan R. V. , Banerjee R. 
Published: October 2018

AbstractWhile the AlCoFeNi high entropy alloy exhibits a single ordered B2 phase at high temperature, both the substitution of ferromagnetic Co with antiferromagnetic Cr, and lower annealing temperatures lead to a tendency for this system to decompose into a two-phase mixture of ordered B2 and disordered BCC solid solution. The length scale of this decomposition is determined by the combination of composition and annealing temperature, as demonstrated in this investigation by comparing and contrasting AlCoFeNi with the AlCo0.5Cr0.5FeNi alloy. The resulting phase stability has been rationalized based on solution thermodynamic predictions. Additionally, it is shown that replacement of Co by Cr in the AlCoFeNi alloy resulted in a substantial reduction in saturation magnetization and increase in coercivity. The microhardness is also strongly influenced by the composition and the length scale of B2 + BCC decomposition in these high entropy alloys.
Amyotrophic Lateral Sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicity
Authors: Nakaya Tadashi , Maragkakis Manolis 
Published: October 2018

AbstractAmyotrophic Lateral Sclerosis (ALS) is a lethal neurodegenerative disorder that primarily affects motor neurons. Dominant mutations in the RNA binding protein Fused in Sarcoma (FUS) have been identified as causative factors of ALS. Mutation, R495X, results in a premature stop codon and induces an aggressive disease phenotype by a largely unknown process. Here, we employ CLIP-Seq, RNA-Seq and Ribo-Seq in cultured neurons expressing R495X or wild-type FUS to identify the mutation effects on the FUS targetome and on the neuronal transcriptome at the expression and translation level, simultaneously. We report that, unlike wild-type FUS that binds on precursor mRNAs (pre-mRNAs), R495X binds mature mRNAs in the cytoplasm. R495X has a moderate effect on target mRNA expression and its binding induces only modest expression changes. In contrast, we find that R495X controls the translation of genes that are associated with mitochondria function and results in significant reduction of mitochondrial size. Importantly, we show that introduction of the 4FL mutation that alters binding of R495X to RNA, partially abrogates R495X-induced effects on mRNA translation, mitochondrial size and neurotoxicity. Our findings uncover a novel RNA-mediated pathway of FUS R495X-induced neurotoxicity that affects mitochondria morphology and provide insight to previous studies associating mitochondria dysfunction to ALS.
Understanding Colour Tuning Rules and Predicting Absorption Wavelengths of Microbial Rhodopsins by Data-Driven Machine-Learning Approach
Authors: Karasuyama Masayuki , Inoue Keiichi , Nakamura Ryoko , Kandori Hideki , Takeuchi Ichiro 
Published: October 2018

AbstractThe light-dependent ion-transport function of microbial rhodopsin has been widely used in optogenetics for optical control of neural activity. In order to increase the variety of rhodopsin proteins having a wide range of absorption wavelengths, the light absorption properties of various wild-type rhodopsins and their artificially mutated variants were investigated in the literature. Here, we demonstrate that a machine-learning-based (ML-based) data-driven approach is useful for understanding and predicting the light-absorption properties of microbial rhodopsin proteins. We constructed a database of 796 proteins consisting of microbial rhodopsin wildtypes and their variants. We then proposed an ML method that produces a statistical model describing the relationship between amino-acid sequences and absorption wavelengths and demonstrated that the fitted statistical model is useful for understanding colour tuning rules and predicting absorption wavelengths. By applying the ML method to the database, two residues that were not considered in previous studies are newly identified to be important to colour shift.
In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization
Authors: Takahashi Kazuhide , Miura Yuri , Ohsawa Ikuroh , Shirasawa Takuji , Takahashi Mayumi 
Published: October 2018

AbstractThe oxygen consumption rate (OCR) and cytochrome c oxidase (CcO) activity of respiratory complex IV (CIV) in brain mitochondria significantly decline in middle-aged male mice compared to younger male mice. To explore the mechanisms underlying the regulation of brain mitochondrial function, we examined CIV-associated proteins, and identified actin inside the isolated brain mitochondria. Inhibiting actin polymerization using cytochalasin B (CB) significantly enhanced the OCR and CcO activity of CIV in the mitochondria. These changes were accompanied by a significant reduction in the amount of CIV-bound cytochrome c (cyt c). Actin was also associated with respiratory complex III (CIII); however, the amount of CIII-bound cyt c increased significantly after treatment of the mitochondria with CB. In contrast, no significant alteration in the assembly or the CcO activity of CIV in CIV-containing supercomplexes or CIV monomers was induced by CB. These results suggest that mitochondrial actin plays a crucial role in the regulation of the CcO activity and OCR of CIV with modification of the retention of cyt c between CIV and CIII.
Self-passivating (Re,Al)B2 coatings synthesized by magnetron sputtering
Authors: Bliem Pascal , Mráz Stanislav , Sen Sandipan , Hunold Oliver , Schneider Jochen M. 
Published: October 2018

Abstract(Re0.67Al0.10)B2 and (Re0.74Al0.11)B2 solid solution as well as Re0.85B2 thin films were deposited by hybrid RF-DC magnetron sputtering. X-ray diffraction (XRD) showed that all films exhibit the ReB2 (P63/mmc) crystal structure. X-ray photoelectron spectroscopy (XPS) analyses performed on atmosphere exposed thin film surfaces suggest that ReB2 corrodes, consistent with literature, by forming perrhenic acid (HReO4) already after two days, while (Re0.74Al0.11)B2 forms a self-passivating Al-oxide layer preventing corrosion in a time period ≥ 60 days. Hence, it is evident that Al additions to ReB2 significantly increase the chemical stability during atmosphere exposure.
Diffusion tensor imaging and voxel-based morphometry reveal corticospinal tract involvement in the motor dysfunction of adult-onset myotonic dystrophy type 1
Authors: Park Jin-Sung , Song Huijin , Jang Kyung Eun , Cha Hyunsil , Lee Sang-Hoon , Hwang Su-Keong , Park Donghwi , Lee Hui Joong , Kim Jun-Young , Chang Yongmin 
Published: October 2018

AbstractMagnetic resonance imaging (MRI) studies have demonstrated that patients with myotonic dystrophy type 1 (DM1) exhibit gray and white matter abnormalities that are correlated with various genetic and neuropsychological measures. However, few MRI studies have focused on the correlations between brain abnormalities and overall motor function including gait performance. Here, we investigated the correlations between brain abnormalities, as assessed with MRI including diffusion tensor imaging (DTI), and motor performance, as assessed with the Medical Research Council sum score (MRCSS), 6-minute walk test (6MWT), and hand grip power, in patients with DM1. Eighteen patients with DM1 and twenty healthy controls participated in this study. The MRCSS and 6MWT reflect patients’ general motor performance, particularly gait, while hand grip reflects the presence of myotonia. We found significant relationships between DTI parameters in the corticospinal tract (CST) and genetic factors and motor performance in patients with DM1. These findings suggest that CST involvement reflecting deterioration of the motor tracts may play a significant role in clinical myotonia. Further, a direct relationship between the cortical gray matter volume and DTI measures in the CST suggests that white matter abnormalities in the CST are strongly associated with volume reductions in the sensorimotor cortex of patients with DM1.
Dietary fibers inhibit obesity in mice, but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal bacterial taxonomic composition
Authors: Drew Janice E. , Reichardt Nicole , Williams Lynda M. , Mayer Claus-Dieter , Walker Alan W. , Farquharson Andrew J. , Kastora Stavroula , Farquharson Freda , Milligan Graeme , Morrison Douglas J. , Preston Tom , Flint Harry J. , Louis Petra 
Published: October 2018

AbstractDietary fibers (DF) can prevent obesity in rodents fed a high-fat diet (HFD). Their mode of action is not fully elucidated, but the gut microbiota have been implicated. This study aimed to identify the effects of seven dietary fibers (barley beta-glucan, apple pectin, inulin, inulin acetate ester, inulin propionate ester, inulin butyrate ester or a combination of inulin propionate ester and inulin butyrate ester) effective in preventing diet-induced obesity and links to differences in cecal bacteria and host gene expression. Mice (n = 12) were fed either a low-fat diet (LFD), HFD or a HFD supplemented with the DFs, barley beta-glucan, apple pectin, inulin, inulin acetate ester, inulin propionate ester, inulin butyrate ester or a combination of inulin propionate ester and inulin butyrate ester for 8 weeks. Cecal bacteria were determined by Illumina MiSeq sequencing of 16S rRNA gene amplicons. Host responses, body composition, metabolic markers and gene transcription (cecum and liver) were assessed post intervention. HFD mice showed increased adiposity, while all of the DFs prevented weight gain. DF specific differences in cecal bacteria were observed. Results indicate that diverse DFs prevent weight gain on a HFD, despite giving rise to different cecal bacteria profiles. Conversely, common host responses to dietary fiber observed are predicted to be important in improving barrier function and genome stability in the gut, maintaining energy homeostasis and reducing HFD induced inflammatory responses in the liver.
The influence of the Atlantic multidecadal oscillation on the eastern Andes low-level jet and precipitation in South America
Authors: Jones Charles , Carvalho Leila M. V. 
Published: October 2018

AbstractThe South America low-level jet (SALLJ) on the eastern slopes of the Andes is a unique climatological feature in the continent. The SALLJ transports large amounts of moisture and controls the spatiotemporal variability of precipitation in southeast South America. This study shows a remarkable influence of the Atlantic Multidecadal Oscillation (AMO) on decadal-to-multidecadal variability of the SALLJ. The results show a consistent pattern in which active SALLJ days during negative AMO phases are associated with negative precipitation anomalies over northern Amazon and the Atlantic Intertropical Convergence Zone (ITCZ). Increased cross-equatorial flow over northwestern South America combined with the outflow associated with the atmospheric subsidence over the negative precipitation anomalies enhances northerly winds along the eastern slopes of the Andes and Amazon. This atmospheric circulation response, which is more prevalent in the austral winter, intensifies the SALLJ. In the exit region of the SALLJ over southern Brazil, Uruguay and northern Argentina, an anomalous low-level cyclonic circulation is associated with enhanced precipitation. The influence of the AMO on the SALLJ is consistent with paleo-proxy studies showing multidecadal changes in precipitation over the La Plata River drainage basin. The analysis shows that secular trends reinforce the SALLJ and precipitation patterns. Moreover, the study highlights the importance of natural variability (i.e., decadal-multidecadal variations) occurring within long-term trends in the mean state, possibly associated with global warming, and significant changes in the SALLJ and precipitation over South America.
Extraction and biomolecular analysis of dermal interstitial fluid collected with hollow microneedles
Authors: Miller Philip R. , Taylor Robert M. , Tran Bao Quoc , Boyd Gabrielle , Glaros Trevor , Chavez Victor H. , Krishnakumar Raga , Sinha Anupama , Poorey Kunal , Williams Kelly P. , Branda Steven S. , Baca Justin T. , Polsky Ronen 
Published: October 2018

AbstractDermal interstitial fluid (ISF) is an underutilized information-rich biofluid potentially useful in health status monitoring applications whose contents remain challenging to characterize. Here, we present a facile microneedle approach for dermal ISF extraction with minimal pain and no blistering for human subjects and rats. Extracted ISF volumes were sufficient for determining transcriptome, and proteome signatures. We noted similar profiles in ISF, serum, and plasma samples, suggesting that ISF can be a proxy for direct blood sampling. Dynamic changes in RNA-seq were recorded in ISF from induced hypoxia conditions. Finally, we report the first isolation and characterization, to our knowledge, of exosomes from dermal ISF. The ISF exosome concentration is 12–13 times more enriched when compared to plasma and serum and represents a previously unexplored biofluid for exosome isolation. This minimally invasive extraction approach can enable mechanistic studies of ISF and demonstrates the potential of ISF for real-time health monitoring applications.
Imidazolate ionic liquids for high-capacity capture and reliable storage of iodine
Authors: Li Ruipeng , Zhao Yanfei , Chen Yu , Liu Zhimin , Han Buxing , Li Zhiyong , Wang Jianji 
Published: October 2018

AbstractFast, efficient capture and safe storage of radioactive iodine is of great significance in nuclear energy utilization but still remains a challenge. Here we report imidazolate ionic liquids (Im-ILs) for rapid and efficient capture, and reliable storage of iodine. These Im-ILs can chemically capture iodine to form I-substituted imidazolate ILs with an iodide counterion and the newly formed ILs can absorb iodine to form polyiodide species and low-temperature eutectic salts. For example, choline imidazolate shows iodine capture capacities of 8.7 and 17.5 g of iodine per gram of IL at 30 and 100 oC, respectively, which are, to the best of our knowledge, higher than the values (0.5–4.3 g/g) reported to date. Importantly, iodine can be stably stored in the Im-IL absorbent systems even at 100 oC. The Im-ILs have potential for application in the capture and storage of radioactive iodine.
A large electroencephalographic motor imagery dataset for electroencephalographic brain computer interfaces
Authors: Kaya Murat , Binli Mustafa Kemal , Ozbay Erkan , Yanar Hilmi , Mishchenko Yuriy 
Published: October 2018

AbstractRecent advancements in brain computer interfaces (BCI) have demonstrated control of robotic systems by mental processes alone. Together with invasive BCI, electroencephalographic (EEG) BCI represent an important direction in the development of BCI systems. In the context of EEG BCI, the processing of EEG data is the key challenge. Unfortunately, advances in that direction have been complicated by a lack of large and uniform datasets that could be used to design and evaluate different data processing approaches. In this work, we release a large set of EEG BCI data collected during the development of a slow cortical potentials-based EEG BCI. The dataset contains 60 h of EEG recordings, 13 participants, 75 recording sessions, 201 individual EEG BCI interaction session-segments, and over 60 000 examples of motor imageries in 4 interaction paradigms. The current dataset presents one of the largest EEG BCI datasets publically available to date.
A database of annual atmospheric acid and nutrient deposition to China’s forests
Authors: Du Enzai 
Published: October 2018

AbstractAnthropogenic emissions have substantially altered atmospheric acid and nutrient deposition in China. Understanding the status and characteristics of acid and nutrient deposition to China’s forests is crucial to assess the consequent impacts, and to better guide forest management options. Based on a comprehensive literature review, here I present an updated database for annual acid and nutrient deposition during the period 1991-2015 in China’s forests (CFAND 2.0). The database includes information from 56 forested sites on the water fluxes of bulk precipitation and throughfall, the concentrations of H+ (pH), dissolved inorganic nitrogen (N) (NH4+ and NO3−), sulfur (S), dissolved phosphorus (P), potassium (K+), calcium (Ca2+) and magnesium (Mg2+) in bulk precipitation and throughfall, and the fluxes of dissolved inorganic N, S, dissolved P, K+, Ca2+ and Mg2+ in bulk deposition and throughfall. This database will help to understand the spatial patterns of acid and nutrient deposition, validate modelling results of acid and nutrient deposition and assess the ecological effects of acid and nutrient deposition in China’s forests.
Phonological Development in a Bilingual Arabic–English-Speaking Child With Bilateral Cochlear Implants: A Longitudinal Case Study
Authors: Sabri Manal , Fabiano-Smith Leah 
Published: October 2018

Purpose
This longitudinal study examined the phonological development of a bilingual Arabic–English-speaking child with bilateral cochlear implants (CIs). The focus of the study was to observe the interaction between her two languages and to observe the effect of CIs on the acquisition of two speech sound systems.

Method
This study followed a 3;6-year-old (2;5 hearing age) bilingual Arabic–English-speaking child with bilateral CIs to age 4;4 (3;2 hearing age). Single-word samples were collected bimonthly in both languages. Phon software (Rose et al., 2006) was used to transcribe and analyze speech samples. Measures derived included Percent Consonants Correct–Revised (Shriberg & Kwiatkowski, 1994), percent vowels correct, phonetic inventory complexity, and common phonological patterns for both English and Arabic.

Results
Our findings supported previous research on phonological development exhibited by children with CIs, with the gradual suppression of typical and atypical error patterns and gradual increase in segmental accuracy with maturation. In addition, language interaction and separation between English and Arabic were found, supporting previous cross-linguistic work on bilingual phonological acquisition (e.g., Fabiano-Smith & Goldstein, 2010b).

Conclusion
Bilingual children with CIs have the capability to learn both of their languages and perform similarly to, and even surpass in accuracy, monolingual children with CIs; however, it is also possible to exhibit a slower rate of acquisition of segmental accuracy as compared to their typically developing, hearing peers. Clinical implications of bilingual early intervention are discussed.
User centric economic demand response management in a secondary distribution system in India
Authors: Eapen Rohit Rajan , Simon Sishaj Pulikottil , Sundareswaran Kinattingal , Nayak Panugothu Srinivasarao 
Published: October 2018

This study presents a demand response (DR) model to curtail the load during peak hours in a secondary (230/440 V) distribution system of Tamil Nadu Generation and Distribution Corporation (TANGEDCO), a state‐owned enterprise, India. TANGEDCO penalises utilities if they violate their permitted contractual limit of demand. Conventional demand control usually curtails a specific region of the secondary distribution network. The limitation of the complete blackout of the particular region in the distribution network increases the loss of load probability. Hence, this project implements an economic DR model in real time using demand side forecasting and by scheduling air‐conditioning loads based on their priority. The pilot project is executed and is monitored at the National Institute of Technology, Tiruchirappalli, India campus. A standard back propagation neural network is used for forecasting a 15 min interval ahead maximum demand in kVA. This economic model comprises of a communication network that uses ON/OFF switching wirelessly controlled relay modules. Finally, the benefits and the strategy involved in the project are presented. It is found that the proposed scheme prevents the electrical demand from exceeding the contractual limit, whereby the penalty due to the violation is zeroed when compared to the previous year.
Seasonal variations in source regions of the dust jets on comet 67P/Churyumov-Gerasimenko
Authors: Lai I.-L. , Ip W.-H. , Lee J.-C. , Lin Z.-Y. , Vincent J.-B. , Oklay N. , Sierks H. , Barbieri C. , Lamy P. , Rodrigo R. , Koschny D. , Rickman H. , Keller H. U. , Agarwal J. , Barucci M. A. , Bertaux J.-L. , Bertini I. , Bodewits D. , Boudreault S. , Cremonese G. , Da Deppo V. , Davidsson B. , Debei S. , De Cecco M. , Deller J. , Fornasier S. , Fulle M. , Groussin O. , Gutiérrez P. J. , Güttler C. , Hofmann M. , Hviid S. F. , Jorda L. , Knollenberg J. , Kovacs G. , Kramm J.-R. , Kührt E. , Küppers M. , Lara L. M. , Lazzarin M. , López-Moreno J. J. , Marzari F. , Naletto G. , Shi X. , Tubiana C. , Thomas N. 
Published: October 2018

Aims. We investigate the surface distribution of the source regions of dust jets on comet 67P/Churyumov-Gerasimenko as a function of time.
Methods. The dust jet source regions were traced by the comprehensive imaging data set provided by the OSIRIS scientific camera.
Results. We show in detail how the projected footpoints of the dust jets and hence the outgassing zone would move in consonance with the sunlit belt. Furthermore, a number of source regions characterized by repeated jet activity might be the result of local topographical variations or compositional heterogeneities.
Conclusions. The spatial and temporal variations in source regions of the dust jets are influenced significantly by the seasonal effect. The strong dependence on the solar zenith angle and local time could be related to the gas sublimation process driven by solar insolation on a surface layer of low thermal inertia.
Camera fabula. La caméra, outil et objet sémiotique complexe en interaction
Authors: Thiburce Julien 
Published: October 2018

L’enquête sur le sens des pratiques et par les pratiques en interaction se déploie aujourd’hui majoritairement par la mobilisation de la caméra. Les enregistrements audio et vidéo d’un événement offrent au chercheur la possibilité d’observer et d’attester de pratiques langagières et culturelles à différents niveaux de granularité (des traits syntaxiques et sémantiques aux aspects gestuels et corporels).Néanmoins, son utilisation et son usage ne sont pas sans poser question, tant sur le terrain même de l’enquête que lors de sa programmation et de son traitementa posteriori. De la même manière que Umberto Eco (1979) a porté un regard sur le rôle du lecteur dans l’interprétation d’un récit littéraire, notre proposition questionne la place de la caméra dans l’expérience et l’interprétation de la ville en interaction, au cours d’une balade urbaine proposée par les musées Gadagne (Ville de Lyon). À la croisée de l’ethnométhodologie et de la sémiotique, la caméra émerge à l’intersection entre un outil qui permet d’attester d’une interaction et un objet qui participe de son déroulement par une perception instrumentée.
Hygienemaßnahmen bei MRSA in (Reha-)Kliniken, Pflegeheimen und häuslicher Krankenpflege
Authors: Jatzwauk Lutz 
Published: October 2018

Zusammenfassung
Herausforderung Auch mit MRSA besiedelte oder infizierte Patienten haben Anspruch auf rehabilitative Leistungen und ausreichende pflegerische und
medizinische Betreuung. Gleichzeitig erwarten berechtigterweise von MRSA nicht betroffene Patienten, durch geeignete Maßnahmen vor einer Besiedlung mit dem Keim
geschützt zu werden. Wie kann das gelingen?
„Patientenkarriere“ von der Akutversorgung bis zur Nachsorge – wo knirscht es?
Authors: Agor Karin 
Published: October 2018

Zusammenfassung
Problempotenzial Eine Akutversorgung im Krankenhaus kann für ältere Menschen an sich schon eine Situation sein, die sie an die Grenzen ihrer Ressourcen
bringt. Ein großes Potenzial an Problemen ergibt sich jedoch auch auf dem weiteren Versorgungsweg.