bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yigu decoction regulates plasma miRNA in postmenopausal osteoporosis patients: a randomized controlled trial
Authors: Chen Haifeng , Zhang Ruikun , Li Guijin , Yan Kun , Wu Ziqi , Zhang Yang , Chen Zhineng , Yao Xinmiao 
Published: November 2024

BackgroundPostmenopausal osteoporosis (PMOP) is a serious condition that affects elderly individuals. Our previous study revealed that Yigu decoction (YGD) effectively improved bone mineral density (BMD) in elderly individuals, but the mechanism underlying this effect remains unclear. In this study, we investigated the relationships among YGD, microRNAs (miRNAs), and bone metabolism by assessing the effects of YGD on the miRNA levels in patient plasma to provide a scientific basis for treating PMOP with YGD.MethodsIn this clinical trial, 60 patients were randomly assigned to the YGD group or the control group (ratio of 1:1) and treated for 3 months. The primary outcome measure was BMD, and the secondary outcome measures included plasma miRNA levels, visual analogue scale (VAS) scores, alkaline phosphatase (ALP) levels, anti-tartrate acid phosphatase (TRACP-5b) levels and traditional Chinese medicine (TCM) syndrome scores. We assessed the regulatory roles of miRNAs in PMOP patients by analysing publicly available data from the Gene Expression Omnibus (GEO) database. Bioinformatics methods were also used to explore the mechanism by which YGD regulates miRNAs that are involved in bone metabolism.ResultsCompared with those before treatment, the BMD, ALP levels, TRACP-5b levels, TCM syndrome scores and VAS scores improved in both groups after 3 months of treatment (P &lt; 0.05). A total of 82 miRNAs differed between the groups. After analysing data from the GEO database, we confirmed that miR-133a-3p is the key molecule that mediates the effects of YGD intervention on PMOP. GO analysis of key genes suggested that gene enrichment was more pronounced in response to hormones, cellular response to growth factor stimulation, and positive regulation of physiological and metabolic processes. KEGG analysis revealed that these genes were enriched mainly in the PI3K-Akt, FOXO, and JAK-STAT pathways and other pathways. The results of the protein‒protein interaction (PPI) network analysis revealed that epidermal growth factor receptor (EGFR), Insulin-like growth factor 1 (IGF-1), Caveolin-1 (Cav-1) and others were core proteins.ConclusionThis study demonstrated that YGD is beneficial in the treatment of PMOP, ameliorating clinical symptoms and bone turnover indices. Moreover, the inhibition of miR-133a-3p expression may be the key mechanisms by which YGD regulates bone metabolism in the treatment of PMOP, although YGD regulates bone metabolism in a multitarget and multipathway manner.
Parental education, Family Health Climate and accelerometer-based measured physical activity and sedentary behavior of primary school-aged children
Authors: Ziegeldorf Alexandra , Hottenrott Nina , Moritz Johanna , Wagner Petra , Wulff Hagen 
Published: November 2024

IntroductionSociodemographic factors such as parental education level (ED) influence the physical activity (PA) and sedentary behavior (SED) of primary school-aged children. In this context, family factors, such as the physical activity-related Family Health Climate (FHCPA), are relevant. However, the effect of FHCPA on the interaction between ED and children’s activity behavior has not yet been investigated. Therefore, this study aimed to analyze the mediating effect of FHCPA on the relation between parental ED and children’s device-based measured PA and SED.MethodsA total of 94 children and their parents participated in the study. Questionnaires were used to assess parental ED and FHCPA. Children’s moderate to vigorous physical activity (MVPA) and SED were measured using accelerometers. Bivariate correlations were conducted to investigate associations between parental ED and MVPA/SED/FHCPA. Mediation analyses were used to investigate the role of FHCPA in the association between maternal and paternal ED and children’s MVPA/SED. Results indicate a small correlation between maternal ED and FHCPA for the total sample (ρ = 0.318, p &lt; 0.001) and a medium correlation for girls only (ρ = 0.570, p &lt; 0.001). Mediation analyses showed no significant mediation effect. However, there was a significant direct association when considering FHCPA in the relation between higher maternal ED and SED in girls compared to lower ED.DiscussionFuture research should examine more complex models to further develop and refine to facilitate the derivation of more effective recommendations for health prevention programs, particularly for mothers and girls.
Inferiority feelings mediate the impact of subjective social support on anxiety/depression symptoms in individuals with physical disabilities
Authors: Liu Yiyang , Xu Wenjing , Liu Shanshan , Song Yuqing , Li Lin , Li Shunfei , Chen Hongguang 
Published: November 2024

BackgroundPersons with physical disabilities are more likely to suffer from psychological symptoms and inferiority feelings, and social support plays an important role in improving those symptoms. However, the interaction between psychological symptoms, inferiority feelings and social support is yet to be understood.MethodsA cross-sectional study was conducted to investigate anxiety, depression, and inferiority feelings among individuals with physical disabilities in a Chinese sample. The questionnaire included the Generalized Anxiety Disorder 7, Patient Health Questionnaire 9, Self-designed Disability Questionnaire, and Social Support Rating Scale including three dimensions: subjective social support, objective social support and utilization of social support.ResultsOut of the 1,453 respondents with physical disabilities, 49.7, 60.4, and 62.5% reported experiencing anxiety, depression, and inferiority feelings, respectively. Factors such as time since identification of physical disabilities, comorbidities, daily travel, social interaction, internet use, subjective social support, and inferiority feelings were found to be associated with anxiety or depression symptoms among physically disabled individuals. Subjective social support was found to be associated with inferiority feelings, which partly mediated the effect of subjective social support on anxiety symptoms by 37.4% and depression symptoms by 28.7%.ConclusionThis study highlights the importance of addressing the psychological well-being of physically disabled individuals in addition to their physical rehabilitation. Psychological intervention strategies should focus on improving subjective social support and reducing inferiority feelings, particularly among vulnerable groups.
Stress in novice nurses in new work environments: a systematic review
Authors: Narbona-Gálvez Ángela , García-Iglesias Juan Jesús , Ayuso-Murillo Diego , Fontán-Vinagre Guadalupe , Gómez-Salgado Juan , Allande-Cussó Regina , Fagundo-Rivera Javier , Macías-Toronjo Israel , Ruiz-Frutos Carlos 
Published: November 2024

BackgroundInexperienced nursing care can compromise the quality of care and the well-being of patients. The aim of this study was to assess the main sources of stress encountered by nurses and novice nurses in a setting not previously experienced.MethodsA systematic review was conducted following the PRISMA format in Pubmed, Scopus, Web of Science, and CINAHL electronic databases in March 2024. A total of 395 studies were identified, of which 16 met the inclusion criteria. Selection was made on the basis of topic relevance and methodological quality, assessed using the critical tools of the Joanna Briggs Institute (JBI).ResultsA total of 16 studies were included in this review. Of the 16 selected, 10 were cross-sectional studies, 3 were cohort studies, 2 were qualitative, and 1 was a systematic review. The studies revealed that the main stressors for novice nurses included time management, workload, and interpersonal relationships. The results underline that organizational factors, such as lack of support and high work demands, play a key role in generating stress.ConclusionIdentifying and addressing the key challenges faced by novice nurses, such as workload, adjustment to the environment, professional expectations, and interpersonal relationships, is crucial to sustain their professional engagement and ensure the quality of health care. This understanding is essential for creating efficient policies and practices that enhance the occupational well-being and stability of nurses in the workforce.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024520651, CRD42024520651.
Understanding childhood obesity in Pakistan: exploring the knowledge, attitudes, practices of mothers, and influential factors. A cross-sectional study
Authors: Hudaib Muhammad , Hussain Laraib , Nazim Laiba , Mohi Uddin Sumaira , Jamil Muhammad Usama , Bham Shireen Qassim , Malik Hurais , Rehman Abdul , Malik Usaid , Manahil  , Umais Ahad Ahmad , Mughal Sanila , Eljack Mohammed Mahmmoud Fadelallah 
Published: November 2024

BackgroundChildhood obesity is a significant public health issue with far-reaching implications. The World Health Organization reported that in 2020, around 38 million children under five were overweight or obese globally, and in 2016, 340 million children and adolescents aged 5–19 were affected. In Pakistan, the situation is alarming; 66.9% of school-going children in Punjab were overweight, and 5.8% were obese in 2022. This study explores mothers’ knowledge, attitudes, and practices regarding childhood obesity in Pakistan and identifies factors contributing to this epidemic. Maternal perspectives are crucial as they significantly influence children’s dietary habits, physical activity, and attitudes toward food and body image.MethodsA cross-sectional study was conducted from November 2023 to January 2024 at four medical centers: Fazaia Ruth Pfau Medical College Hospitals Karachi, Baqai Medical University Karachi, and Nishtar Medical University Multan. The study included 191 mothers with children aged 5 to 15 years. Data were collected using a structured questionnaire on sociodemographic characteristics, knowledge, attitudes, practices, and perceptions of childhood obesity. IBM-SPSS version 26.0 was used for data analysis, employing statistical tests like Kruskal-Wallis, Mann–Whitney U, Spearman, or Kendall Tau correlation to examine associations.ResultsAmong the 191 mothers, 48.7% had education beyond intermediate, and 86.9% were housewives. The children’s BMI distribution showed that 27.7% were obese and 21.5% overweight. Mothers had moderate knowledge (60.5%) about childhood obesity; 75.4% recognized its long-term health risks, and 62.8% associated it with diabetes. Attitudes were generally positive, with a 78.5% average score. Most mothers (73.8%) believed obesity could be controlled and had healthy practices (70.1% average score). However, 96.9% reported witnessing stigmatization of obese children, and 79.6% felt pressured by relatives about their child’s weight.ConclusionThe findings indicate that while Pakistani mothers have moderate knowledge and positive attitudes toward childhood obesity, their practices are influenced by educational and socioeconomic factors. Addressing these disparities, enhancing public health initiatives, and mitigating stigmatization could improve childhood obesity management in Pakistan.
Public attitudes toward the use of human induced pluripotent stem cells: insights from an Italian adult population
Authors: Elia Noemi , Prinelli Federica , Peli Valeria , Conti Silvia , Barilani Mario , Mei Cecilia , Castaldi Silvana , Lazzari Lorenza 
Published: November 2024

IntroductionHuman induced pluripotent stem cells (hiPSCs), derived from reprogrammed adult somatic cells, hold significant promise for disease modelling, personalized medicine, drug discovery, and regenerative therapies. Public awareness and understanding of hiPSCs are crucial for advancing research in this field. However, limited data exists on the general population’s knowledge and attitudes toward their use.MethodsThis study aimed to assess the awareness and perceptions of hiPSCs among Italian adults through a web-based survey conducted via the EUSurvey platform, using a snowball sampling approach. The survey included demographic information and mandatory questions on knowledge, awareness, and concerns regarding hiPSC technology, with responses collected on a 3-point scale. Statistical analysis was performed using chi-squared tests, with significance set at p ≤ 0.05.ResultsOut of 1874 respondents, the majority were aged 18–35 years (40.5%), female (63.4%), and university-educated (67.2%). Among those familiar with hiPSCs (54.1%, n = 1,201), 95.3% expressed willingness to donate blood samples for hiPSC generation to treat individuals with incurable diseases. Concerns about current research and therapeutic applications were low (less than 20%), but nearly half of the respondents were hesitant or opposed to the use of hiPSCs in animal experiments and their commercialization by pharmaceutical companies. Increased skepticism was observed in older, less educated, religious individuals, and those who were not blood donors. Overall, the Italian public shows strong support for hiPSC-based therapies, though reservations exist around specific ethical and economic issues.DiscussionThese findings underscore the importance of addressing public concerns through targeted educational campaigns, not only in Italy but globally, to foster a more informed and supportive environment for advancing stem cell research and its clinical applications worldwide. Similar studies have been conducted in Japan, the United States, and Sweden, but there remains a need for all countries to engage with their citizens to better understand how stem cell research is perceived locally. Such engagement is crucial for guiding international strategies in personalized medicine and regenerative therapies, ensuring that emerging technologies are met with both ethical integrity and public trust.
Not all Christian nationalists are White (and not all White Christians are Christian nationalists): exploring the predictors of Christian nationalism
Authors: Everton Sean F. 
Published: November 2024

IntroductionIn recent years, the literature on Christian nationalism has grown exponentially. Studies have found that individuals who score high on a widely used Christian nationalism scale are likelier to advocate for traditional gender roles, endorse anti-immigrant policies, support policies limiting voting rights, oppose gun control and interracial marriage, express anti-vaccine attitudes, hold anti-globalist sentiments, and vote for Donald Trump. The literature on Christian nationalism is not without its critics, however. Some, for example, have questioned whether the scale used by many studies adequately identifies Christian nationalists and suggested alternative methods for doing so. Much of the literature also implicitly or explicitly equates Christian nationalism with white Christian nationalism, ignoring the fact that 25 to 30 percent of respondents who express Christian nationalist sentiments identify as Black, Hispanic, Asian, or another race or ethnicity. Finally, most of it has focused on the consequences of Christian nationalism. Very little has explored the predictors of Christian nationalism. The latter is the focus of this paper.MethodsDrawing on multivariate logistic regression, it examines potential factors driving Christian nationalist attitudes.ResultsIt finds that age, whether someone identifies as a conservative or a Republican, biblical literalism, and frequent worship attendance are positively associated with Christian nationalism, while being affiliated with religious traditions other than evangelicalism (or having no affiliation at all) is negatively associated with it. Notably, race and ethnicity have no effect, suggesting that other factors may be at work.DiscussionAs such, the paper briefly considers four potential factors not readily captured by statistical analyses of cross-sectional data. It concludes by noting that if Christian nationalism is potentially undemocratic and dangerous, then concerned individuals need to focus as much time and energy on its predictors as its consequences.
Stereoscopic objects affect reaching performance in virtual reality environments: influence of age on motor control
Authors: Kim Hyeonseok , Kim Yeongdae , Lee Jongho , Kim Jaehyo 
Published: November 2024

Although the stereoscopic effect in 3D virtual reality (VR) space has been studied, its influence on motor performance, specifically how stereoscopic objects affect behavioral outcomes like reaching, remains unclear. Previous research has primarily focused on perceptual aspects rather than on how stereoscopic visual input impacts motor control at the behavioral level. Thus, we investigated the effects of stereoscopic objects in a VR environment on reaching performance, examining whether the stereoscopic effect of objects is a significant aspect enough to affect performance at the behavioral level. While doing so, we investigated young and older adults separately, as age is a critical factor influencing motor performance. Fourteen young and 23 older participants performed a reaching task in the VR space. The target objects were 2D and 3D, deviating from the initial position by 10 and 20 cm. The movement attributed to feedforward control was analyzed using end-point error and smoothness of movement. Our results revealed that older participants had significantly worse predictive control than young participants in the 3D long task, suggesting that the positions of 3D objects were more difficult to predict than those of 2D objects. Young participants showed a significant difference in smoothness between 2D and 3D objects, which was not observed in older participants. This may reflect the floor effect in older participants. Under the short-distance condition, neither group showed a significant difference, suggesting the ceiling effect by distance. We confirmed that the effect of stereoscopic objects was not drastic but it did hamper the reaching performance.
Comprehensive evaluation of fertilizer treatments on biometric traits and marketable tuber weight across diverse potato varieties
Authors: Sibirev Alexey V. 
Published: November 2024

IntroductionThe efficiency of potato production depends to a large extent on the production of quality seeds that meet the requirements of the growing region. The main component of this production includes breeding, which creates the genetic basis of seeds. The process of establishing patterns between the amount of fertilizer application (“Aquarin 12,” “Bona Forte,” “Osmocote Exact High K”), their type, and biometric characteristics of potato plants of the studied varieties “Guliver,” “Beauty of Meshchera,” and “Grand” was explored.MethodsDuring the experimental studies, the methods of variation statistics, the technique of field experiment with the corresponding transformations to achieve normal distribution, and subsequent dispersion analysis were used.ResultsThe results of the research on the evaluation of potato structural elements depending on the plant nutrition system of the studied varieties testify to the expediency of using nutrient solutions in potato cultivation irrespective of their type. In addition, it has been established that increasing the concentration of the nutrient base solution from 75 to 125% of the nutrient formula improves the quality indicators of minitubers, namely the content of starch, sugars, dry matter, crude protein, phosphorus, specific gravity, and ash content, which can contribute to obtaining high-quality potatoes.DiscussionThus, the use of morphological and physiological tools in closed ecosystems is informative for predicting key agricultural characteristics of potato plants. Additionally, integrating organic amendments and biofertilizers, as supported by other studies, could further enhance nutrient uptake and plant health, especially under conditions of low irrigation.
Internally Harmonic Matched Compact GaN Power Amplifier with 78.5% PAE for 2.45 GHz Wireless Power Transfer Systems
Authors: Li Caoyu , Zhang Ziliang , Pei Yi , Chen Changchang , Feng Gang , Xu Yuehang 
Published: November 2024

In this paper, a high-efficiency compact power amplifier is designed and fabricated with a 0.25 μm GaN high electron mobility transistor (HEMT) to meet the demands of a high integration level and high efficiency for microwave wireless power transfer (WPT) systems. The proposed power amplifier (PA) is implemented using an internally matched method to achieve a compact circuit size. The output second and third harmonic impedances can be optimized through output matching circuits, eliminating the need for additional harmonic matching networks. This approach simplifies the design of matching circuits and reduces the circuit size. Furthermore, the input third harmonic has been controled for improving the efficiency of DC-to-RF conversion. The total size of the proposed PA is 13.4 × 13.5 mm2. The test results obtained from the continuous wave (CW) testing indicate that the output power of the power amplifier at 2.45 GHz reaches 43.75 dBm. Additionally, the large-signal gain is measured at 15.75 dB, and the power-added efficiency (PAE) achieves a value of 78.5%.
Peran Teknologi Informasi Dalam Pendidikan Agama Islam Untuk Menghadapi Tantangan Di Era Global Dan Generasi Z
Authors: Abdul Hamid Arribathi  , Dedeh Supriyanti  , Erna Astriyani  , Agung Rizky  
Published: November 2024

ABSTRAK
Harapan dalam penelitian ini untuk meningkatkan pendidikan pada agama islam dan mencerahkan pola pikir para Generasi Z dengan menggunakan media teknologi informasi berbasis web atau lain sebagainya, meminimalisir keterbatasan umat manusia dalam menempuh pendidikan, karena sebagaimana islam mewajibkan umatnya untuk menjadi umat yang berpendidikan/berilmu, berakhlakul karimah dan takwa kepada sang maha pencipta Allah SWT. Untuk memberikan ke arah jalan yang benar pada generasi- generasi muda akan sangat penting sekali pembelajaran agama islam dalam dunia pendidikan dan berdasarkan pada (HR. Ahmad) "Barangsiapa yang hendak menginginkan dunia, maka hendaklah ia menguasai ilmu. Barangsiapa menginginkan akhirat, hendaklah ia menguasai ilmu. Dan barang siapa yang menginginkan keduanya (dunia dan akhirat), hendaklah ia menguasai ilmu.". Prosedur penelitian ini dimulai dengan melakukan analisis menggunakan dua metode diantaranya metode studi pustaka dan metode deskriptif, dengan membentuk media informasi pada sebuah platform akan dibuat database mysql, laravel dan lain sebagainya sebagai pendukung.

Kata kunci : Pendidikan Agama Islam, Teknologi Informasi, studi pustaka, Umat Manusia

ABSTRACT
The hope in this study is to improve education in Islam and enlighten the mindset of Generation Z by using web-based or other information technology media, minimizing the limitations of mankind in taking education, because as Islam requires its people to be educated/knowledgeable people, have good morals. and piety to the creator, Allah SWT. To direct the younger generations in the right direction, it will be very important to study Islam in the world of education and it is based on (HR. Ahmad) "Whoever wants to want the world, then let him master knowledge. Whoever wants the afterlife, let him master knowledge And whoever wants both (the world and the hereafter), let him master knowledge.". The initial procedure begins by conducting analysis using two methods including the literature study method and the descriptive method, by forming information media on a platform that will use MySQL, Laravel, and other databases as support.
Keywords: Islamic Religious Education, Information Technology, Library Studies, Humanity