bluuebunny/crossref_metadata_2025_split huggingface dataset:
AnyAbility: creating a library service model for adults with disabilities
Authors: McGowan Suzanne , Martinez Hannah , Marcilla Marsha 
Published: September 2018

Purpose
This paper aims to illustrate the importance of a cultural shift to fully embrace and serve persons with cognitive, intellectual or physical disabilities into the library community.

Design/methodology/approach
Through a combination of staff training, age- and ability-appropriate programming, accommodating service models, management-led expectations and partnerships, Anythink Libraries in Thornton, Colorado, implemented AnyAbility – a program designed especially for adults with disabilities – in April 2014.

Findings
AnyAbility’s success has led to a number of positive impacts, including increased services and collaboration, shifts in user patterns and independent visits and a more inclusive library environment in which staff have increased awareness and a stronger interaction with this population.

Originality/value
The program has transformed the lives of the staff who work at Anythink Wright Farms and the community of Anythinkers who use transformations, the AnyAbility programming has been offered at multiple Anythink locations and libraries from across the country have contacted Anythink for inspiration and advice on programs and training on this topic. Most importantly, this approach has transformed the library experience for customers, specifically adults with cognitive disabilities.
The experiences of mothers of children with autism spectrum disorder: Managing family routines and mothers’ health and wellbeing
Authors: McAuliffe Tomomi , Thomas Yvonne , Vaz Sharmila , Falkmer Torbjorn , Cordier Reinie 
Published: September 2018

Background/aimFamilies of children with autism spectrum disorder (ASD) use family routines to provide predictability and structure to support occupational engagement of their family members. Mothers assume the major role to orchestrate occupations in constructing family routines, which may impact their health and wellbeing. However, the experiences of mothers in managing family routines and their health and wellbeing have not been the main focus in previous research. Thus, this study explored the experiences of mothers of children with ASD in managing family routines and their perceptions of the impact of family routines on their health and wellbeing.MethodsAn interpretive phenomenological approach was used. Twenty mothers of children with ASD, aged between 28 and 56 years, participated in semi‐structured interviews. Data were transcribed verbatim and each transcript was analysed.ResultsFive themes that summarise mothers’ perceptions towards health and wellbeing when managing family routines emerged: (i) Keeping on track keeping healthy; (ii) My life is busy, because I do everything for everyone else; (iii) Keeping on track all the time is tiring or frustrating; (iv) Looking after my family by looking after myself; and (v) I am not perfect and it is OK.ConclusionThis study highlighted the substantial efforts required in constructing family routines that may be at the cost of mothers’ health and wellbeing. However, mothers may be able to cope with everyday demands in managing family routines by changing their perspectives. By integrating ‘me‐time’ activities in family routines, mothers may be able to support their own health and wellbeing. Mothers’ values and needs are reflected in family routines; hence, thorough understanding of family routines may be a key to support mothers’ occupational engagement.
Concentrated insulins: History and critical reappraisal
Authors: Heinemann Lutz , Beals John M. , Malone James , Anderson James , Jacobson Jennie G. , Sinha Vikram , Corrigan Sheila M. 
Published: September 2018

AbstractThe earliest marketed insulins were crude acidic formulations with concentrations of ≤10 units/mL. Since the early 1920s, insulins have improved continually, via bioengineering, process, and chemical modifications. Today, most insulin formulations have a concentration of 100 units/mL (U100). However, more concentrated insulin formulations (200, 300, and 500 units/mL; U200, U300, and U500, respectively) are also available. There is a tendency to assume that concentrated insulins are similar, both to each other and to their U100 counterparts, but this is not always the case: two concentrated insulins, namely insulin degludec U200 and insulin lispro U200, are bioequivalent to their U100 counterparts, whereas regular human insulin U500 and insulin glargine U300 are not. The advent of these concentrated insulins offers greater opportunities to provide tailored therapy for patients; it also introduces potential confusion, and highlights the need for prescriber and patient education. Precise and accurate dedicated insulin delivery devices are also necessary for the safe use of these concentrated insulins. Although some clinicians only use concentrated insulin with obese and severely insulin‐resistant patients, other patients would also benefit from the reduced injection volume associated with concentrated insulins, or the modified time‐action profile of some concentrated insulins. The aim of this review is to enhance understanding of the historic development and the safe and effective use of concentrated insulins in clinical practice.
Impact of prolonged and early bevacizumab treatment on the overall survival of EGFR‐mutant and EGFR‐wild type nonsquamous non‐small cell lung cancer
Authors: Huang Yu‐Chen , Shen Shih‐Min , Liu Chien‐Ying , Pavlidis Stelios , Wang Chih‐Liang , Ko How‐Wen , Chung Fu‐Tsai , Lin Tin‐Yu , Feng Po‐Hao , Lee Kang‐Yun , Guo Yi‐Ke , Yang Cheng‐Ta , Kuo Chih‐Hsi Scott 
Published: September 2018

BackgroundVEGF plays a key role in tumor angiogenesis and immunosuppression. VEGF‐blocking has proven beneficial for EGFR mutant and wild‐type nonsquamous non‐small cell lung cancer (nonsq‐NSCLC); however, the number of cycles and treatment line yielding the optimal benefit are unknown.MethodsWe retrospectively analyzed the data of 115 patients with advanced/metastatic nonsq‐NSCLC administered at least one cycle of bevacizumab. The number of bevacizumab cycles was treated as a time‐dependent covariate. Predictors of overall survival (OS) were investigated.ResultsBevacizumab was used as first‐line treatment in 47 (40.9%) patients, with a median of five cycles (range: 1–31). Eastern Cooperative Oncology Group performance status ≥ 2 (hazard ratio [HR] 4.78, 95% confidence interval [CI] 2.68–8.51; P < 0.001), wild‐type EGFR (HR 2.61, 95% CI 1.45–4.70; P = 0.001), and bleeding during bevacizumab treatment (HR 3.63, 95% CI 1.77–7.45; P < 0.001) were predictive of poor OS; the number of bevacizumab cycles and first‐line administration were not. In the wild‐type EGFR subgroup, the number of bevacizumab cycles (≥ 5 vs. 1–4) was associated with a significant OS benefit (HR 0.28, 95% CI 0.08–0.98; P = 0.044); first‐line administration also showed an OS benefit (HR 0.48, 95% CI 0.20–1.17; P = 0.105). A significant association between the number of cycles and EGFR status was identified (P = 0.046).ConclusionOS benefit is negatively affected by bleeding events in bevacizumab‐treated patients. Prolonged and early introduction of bevacizumab may provide an OS benefit for patients with wild‐type EGFR nonsq‐NSCLC.
Treating Lyme carditis high‐degree AV block using a temporary–permanent pacemaker
Authors: Wang Chang , Chacko Sanoj , Abdollah Hoshiar , Baranchuk Adrian 
Published: September 2018

AbstractA 28‐year‐old previously healthy male presented with nonprodromal syncope and a 4‐day history of chest pain, shortness of breath, and malaise. His ECG showed rapidly progressive high‐degree AV block. His Suspicious Index in Lyme Carditis (SILC) score was 8, indicating high risk for Lyme carditis. Lyme serology revealed to be positive (anti‐Lyme IgM). During the second day of hospitalization, the patient deteriorated his AV conduction, and a temporary–permanent pacemaker was implanted allowing ambulating in hospital the very same day. Temporary–permanent pacemakers for the management of transient high‐degree heart block associated with Lyme carditis were only occasionally used in the past.
Association of spontaneous labor onset with neonatal outcomes in pregnancies with fetal gastroschisis: A retrospective cohort analysis
Authors: Osmundo Junior Gilmar de Souza , Mohamed Samirah Hosney Mahmoud , Nishie Estela Naomi , Tannuri Ana Cristina Aoun , Gibelli Maria Augusta Bento Cicaroni , Francisco Rossana Pulcineli Vieira , Brizot Maria de Lourdes 
Published: September 2018

AbstractIntroductionThe present study aims to investigate the association of spontaneous labor onset with neonatal outcomes in pregnancies with fetal gastroschisis. The secondary goal was to evaluate the association between ultrasound markers and labor onset in pregnancies with fetal gastroschisis.Material and methodsA retrospective analysis was performed for 207 pregnancies with fetal gastroschisis between 2005 and 2017. Patients were followed according to a strict protocol involving ultrasound scans and routine evaluations of fetal biophysical profile parameters and intra‐ and extra‐abdominal bowel diameters. Labor, delivery and neonatal records were reviewed. The neonatal outcomes were complex gastroschisis, staged surgical closure of the abdominal defect, short bowel syndrome, time on mechanical ventilation, time to full enteral feeding and necrotizing enterocolitis.ResultsSpontaneous labor onset was associated with complex gastroschisis (30.7% vs 6.8%,P = 0.002) and short bowel syndrome (13.2% vs none,P = 0.013) in cases with spontaneous preterm delivery compared with the indicated preterm deliveries. Spontaneous labor onset was associated with a longer time on mechanical ventilation for term and preterm newborns. Associations were not observed between ultrasound markers and spontaneous labor onset.ConclusionsSpontaneous labor onset in pregnancies with fetal gastroschisis was associated with adverse neonatal outcomes, particularly in those born preterm.
Zero Diffusive Sodium Balance in Hemodialysis Provided by an Algorithm‐Based Electrolyte Balancing Controller: A Proof of Principle Clinical Study
Authors: Kuhlmann Uwe , Maierhofer Andreas , Canaud Bernard , Hoyer Joachim , Gross Malte 
Published: September 2018

AbstractRestoring and controlling fluid volume homeostasis is still a challenge in contemporary end‐stage kidney disease patients treated by intermittent hemodialysis (HD) or hemodiafiltration (HDF). This primary target is achieved by ultrafiltration (dry weight probing) and control of intradialytic sodium transfer (dialysate‐plasma Na gradient). The latter task is mostly ignored in clinical practice by applying a dialysate sodium prescription uniform for all patients of the dialysis center but unaligned to individual plasma sodium levels. Depending on the patient’s natremia, a positive gradient gives rise to intradialytic diffusive sodium load and postdialytic thirst. On the contrary, a negative gradient may cause unwanted diffusive sodium removal and intradialytic symptoms. To overcome these challenges, a new conductivity‐based electrolyte balancing algorithm embedded in a hemodialysis machine with the aim to achieve “zero diffusive sodium balance” in HD and online HDF treatments was tested in the form of a prospective clinical trial. The study comprised two phases: a first phase with a conventional fixed‐sodium dialysate (standard care phase), followed by a phase with the electrolyte balancing control (EBC) module activated (controlled care phase). The results show a reduction in the variability of the intradialytic plasma sodium concentration shift, but it is overlain by a small but statistically significant increase in the mean plasma sodium levels. However, no clinical manifestations were observed. This sodium load can be explained by the design of the algorithm based on dialysate conductivity instead of sodium concentration. Furthermore, the increase in plasma sodium can be corrected by taking into account the potassium shift during the treatment. This study showed that the EBC module incorporated in the HD machine is able to automatically individualize the dialysate sodium to the patient’s plasma sodium without measuring or calculating predialytic plasma levels from previous laboratory tests. This tool has the potential to facilitate fluid management, to control diffusive sodium flux, and to improve intradialytic tolerance in daily clinical practice.
The Influence of Rotary Blood Pump Speed Modulation on the Risk of Intraventricular Thrombosis
Authors: Liao Sam , Wu Eric L. , Neidlin Michael , Li Zhiyong , Simpson Benjamin , Gregory Shaun D. 
Published: September 2018

AbstractRotary left ventricular assist devices (LVADs) are commonly operated at a constant speed, attenuating blood flow pulsatility. Speed modulation of rotary LVADs has been demonstrated to improve vascular pulsatility and pump washout. The effect of LVAD speed modulation on intraventricular flow dynamics is not well understood, which may have an influence on thromboembolic events. This study aimed to numerically evaluate intraventricular flow characteristics with a speed modulated LVAD. A severely dilated anatomical left ventricle was supported by a HeartWare HVAD in a three‐dimensional multiscale computational fluid dynamics model. Three LVAD operating scenarios were evaluated: constant speed and sinusoidal co‐ and counter‐pulsation. In all operating scenarios, the mean pump speed was set to restore the cardiac output to 5.0 L/min. Co‐ and counter‐pulsation was speed modulated with an amplitude of 750 rpm. The risk of thrombosis was evaluated based on blood residence time, ventricular washout, kinetic energy densities, and a pulsatility index map. Blood residence time for co‐pulsation was on average 1.8 and 3.7% lower than constant speed and counter‐pulsation mode, respectively. After introducing fresh blood to displace preexisting blood for 10 cardiac cycles, co‐pulsation had 1.5% less old blood in comparison to counter‐pulsation. Apical energy densities were 84 and 27% higher for co‐pulsation in comparison to counter‐pulsation and constant speed mode, respectively. Co‐pulsation had an increased pulsatility index around the left ventricular outflow tract and mid‐ventricle. Improved flow dynamics with co‐pulsation was caused by increased E‐wave velocities which minimized blood stasis. In the studied scenario and from the perspective of intraventricular flow dynamics, co‐pulsation of rotary LVADs could minimize the risk of intraventricular thrombosis.
Evaluation of screening for coeliac disease in children with juvenile idiopathic arthritis
Authors: Öman Anders , Hansson Tony , Carlsson Martin , Berntson Lillemor 
Published: September 2018

AbstractAimTo study the prevalence of coeliac disease (CD) in children with Juvenile idiopathic arthritis (JIA), by screening a population‐based cohort of children with JIA using autoantibodies against tissue transglutaminase (anti‐TG2).MethodsAll children diagnosed with JIA in three Swedish counties, with disease onset between 2007 and 2014, were included prospectively. Serum levels of IgA anti‐TG2 antibodies, IgG anti‐TG2 antibodies, and total IgA were analysed. Children with positive levels of IgA anti‐TG2 antibodies and children with IgA deficiency in combination with positive levels of IgG anti‐TG2 antibodies were referred to the paediatric gastroenterology unit for gastroscopy and small intestine biopsy.ResultsA total of 216 children were included, and analysis of IgA and IgG anti‐TG2 antibodies was performed in 213 children. Three children were diagnosed with CD prior to the diagnosis of JIA, and three additional children were found through screening, resulting in a CD point prevalence of 2.8% (95% CI 0.6–5.0%).ConclusionWe found a point prevalence of CD close to previous described prevalence in the general population of Swedish children. Therefore, general screening for CD in children with JIA is not supported by our data. However, this study shows that asymptomatic CD in children with JIA may be found by screening.
Medical and dental applications of nanomedicines
Authors: Kavoosi Fraidoon , Modaresi Farzan , Sanaei Masumeh , Rezaei Zahra 
Published: September 2018

Nanoparticles are tiny materials with nanosized components less than 100 nm in at least one dimension with physicochemical properties, which make them very attractive for medical application. These compounds have been evaluated as potential medicines for several decades. Nanotechnology has provided advances in the various fields of health sciences such as diagnosis, prevention and treatment by application of the agents named nanomedicines, including proteins, polymers, micelles, dendrimers, liposomes, emulsions, nanocapsules and nanoparticles. These materials can act as a scaffold, gene/drug delivery, tumor suppressor, conjugated with surgical implant, etc. They can also use as a nanocomposite, artificial tooth and dental caries preventing agent in the dentistry science. This current review tries to summarize recent applications of nanomedicine in the medical and dental fields.
Robotic surgery in pediatric urology: Current status
Authors: Mizuno Kentaro , Kojima Yoshiyuki , Nishio Hidenori , Hoshi Seiji , Sato Yuichi , Hayashi Yutaro 
Published: September 2018

AbstractRobot‐assisted laparoscopic surgery (RALS) has been increasingly embraced in the fields of adult and pediatric urology, especially in North America and Europe. The advantages of a stable magnified 3‐D view, tremor filtering, and motion scaling allow for precise intracorporeal exposure and suturing. Because most surgeries are performed as reconstructive rather than excision procedures, the robotic platform is particularly feasible for the field of pediatric urology. In this review, we summarize the recent viewpoints on RALS, such as pyeloplasty, ureteral reimplantation, bladder neck reconstruction, bladder neck sling, appendicovesicostomy, bladder diverticulectomy, and treatments for ureterocele or ectopic ureters, and we also critically summarize the current status of the literature. Based on our initial experience, RALS is technically feasible for pediatric patients and may be achieved with comparable surgical outcomes. RALS is also associated with reduced morbidity compared to open surgery to conventional laparoscopic surgery. This evolution will offer an alternative in the treatment pediatric patients, along with improved care and patient quality of life. Further large case series and randomized controlled trials that investigate the robotic platform's technological improvements will help to expand indications of RALS in the field of pediatric urology.
A Corporate Social Responsibility Analysis of Payday Lending
Authors: Schwartz Mark S. , Robinson Chris 
Published: September 2018

AbstractIn this article, we use a corporate social responsibility (CSR) framework to analyze the payday loan industry by critically examining its practices from an economic, legal, and ethical perspective. Payday loans are essentially a very high cost, unsecured, short‐term personal loan. Given the inherent nature of the product being offered, the industry appears on the face of it to be in a position to potentially exploit vulnerable consumers in pursuit of profits. With this concern in mind, our analysis investigates the following three issues: Can the payday loan industry currently be considered to be acting in a socially responsible manner? If the industry cannot be considered to be socially responsible, should it be further regulated? If the industry should be further regulated, how should it be regulated? To address these issues, we first provide a brief historical overview of payday loans. Second, we describe the important characteristics of payday loans and how the industry operates. Third, we draw on various sources of evidence to demonstrate that the payday loan industry, while fulfilling its basic economic obligations, falls outside of both the legal and ethical domains of the Three Domain Model of CSR. Based on our analysis, our conclusion is that the payday loan industry requires additional government legal regulation, particularly with respect to allowable fees, and we conclude that there is a strong ethical case for banning payday loans altogether.
Exploring and Comparing Cognitive Moral Reasoning of Millennials and Across Multiple Generations
Authors: Weber James , Elm Dawn R. 
Published: September 2018

AbstractThis research builds on previous investigations seeking to understand how individuals reason about moral problems. Our research includes a preliminary investigation about Millennials and a cross‐generational analysis using secondary research data to understand this emerging generation's moral reasoning and assess trends in moral reasoning over time. This study addresses content‐bias in moral reasoning by using a new instrument with business‐based dilemmas, the Moral Recognition Interview, based on the well‐established moral reasoning framework of Lawrence Kohlberg. Results show that the Millennials in this study exhibit differences in moral reasoning based on gender, intelligence, work experience, and academic major, however not necessarily in an expected manner. Differences in moral reasoning were found when the context or “story pull” of the ethical dilemmas presented is considered. In addition, a comparison to other studies shows that business student Millennials tend to reason at lower levels of cognitive moral reasoning than non‐business college students, as well as college students in the 1960s–1970s (Baby Boomers) and in the 1980s–1990s (Generation Xers).
Multinational Enterprises, Employee Safety and the Socially Responsible Supply Chain: The Case of Bangladesh and the Apparel Industry
Authors: Hemphill Thomas A. , White George O. 
Published: September 2018

AbstractThis article address the issue of employee safety and the social responsibility of multinational apparel retailers who contract with Bangladesh manufacturers in their global supply chain. Both the Alliance for Bangladesh Worker Safety and the Accord on Fire and Building Safety in Bangladesh have been identified as the two primary facilitators for global apparel industry efforts to actively address this serious human rights issue; thus, they have the potential to help drive the success of the industry's corporate citizenship efforts to successfully manage the issue of fire and building safety in Bangladesh. The article further explores these relationships within the context of the “global corporate citizenship” concept, and develops a rationale for the limits of a socially responsible supply chain. In the context of global corporate citizenship, the article describes the existing state of these two industry organizations remediation efforts to ensure a stable supply chain in Bangladesh, and offers an analysis of existing industry nonmarket strategy approaches to improving contractor's factory fire and building safety environments for their employees. Lastly, a comprehensive set of nonmarket strategies for multinational apparel retailers is recommended when addressing their global corporate citizenship commitments to a safe working environment for Bangladesh garment manufacturing employees.