bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibacterial activity of total flavonoids from Ilex rotunda Thunb. and different antibacterials on different multidrug-resistant bacteria alone or in combination
Authors: Wu Yongji , Chai Beibei , Wang Lizhen , Jiang Weijia , Hu Mei , Zhao Yuchuan , Si Hongbin 
Published: October 2018

AbstractThe problem of bacterial resistance is becoming more and more serious, which has become an urgent problem to be solved in human and veterinary. One approach to control and delay bacterial resistance is combination therapy in which antibiotics are given together with other antimicrobial or non-antimicrobial agents. Studies have shown that flavonoids from Traditional Chinese medicine (TCM) possess a high level of antibacterial activity against antibiotic resistant strains. The aim of this study was to evaluate the antibacterial effects of a combined therapy of total flavonoids from Ilex rotunda Thunb. and antibiotics against seven kinds of veterinary bacteria which were multidrug resistance bacteria. A microdilution checkerboard method was used to determine the minimal inhibitory concentrations of both types of antimicrobials, alone and in combination. The fractional inhibitory concentration index was calculated and used to classify observed collective antibacterial activity as synergistic, additive, indifferent or antagonistic.From the performed tests, the total flavonoids and antimicrobial agents were combined to inhibit different multidrug-resistant bacteria, such as Escherichia coli, Streptococcus, Pseudomonas aeruginosa, Enterococcus faecalis, Proteus vulgaris, Staphylococcus aureus, Acinetobacter baumannii. For these bacteria, total flavonoids from Ilex Rotunda Thunb. presented synergistic or additive with different antibiotics and had a certain antibacterial effect on the separated multidrug-resistant bacteria. The study shows total flavonoids from Ilex rotunda Thunb. have potential as adjuvants for the treatment of animal bacterial diseases.
External evaluation of population pharmacokinetic models for vancomycin in neonates
Authors: Tasa Tõnis , Kalamees Riste , Vilo Jaak , Lutsar Irja , Metsvaht Tuuli 
Published: October 2018

AbstractIntroductionNumerous vancomycin population pharmacokinetic (PK) models of neonates have been published. We aimed to comparatively evaluate a set of these models by quantifying their model-based and Bayesian concentration prediction performances using an external retrospective dataset, and estimate their attainment rates in predefined therapeutic target ranges.MethodsImplementations of 12 published PK models were added in the Bayesian dose optimisation tool, DosOpt. Model based concentration predictions informed by variable number of individual concentrations were evaluated using multiple error metrics. A simulation study assessed the probabilities of target attainment (PTA) in trough concentration target ranges 10–15 mg/L and 10–20 mg/L.ResultsNormalized prediction distribution error analysis revealed external validation dataset discordances (global P < 0.05) with all population PK models. Inclusion of a single concentration improved both precision and accuracy. The model by Marques-Minana et al. (2010) attained 68% of predictions within 30% of true concentrations. Absolute percentage errors of most models were within 20-30%. Mean PTA with Zhao et al. (2013) was 40.4% [coefficient-of-variation (CV) 0.5%] and 62.9% (CV 0.4%) within 10–15 mg/L and 10–20 mg/L, respectively.ConclusionPredictive performances varied widely between models. Population based predictions were discordant with external validation dataset but Bayesian modelling with individual concentrations improved both precision and accuracy. Current vancomycin PK models achieve relatively low attainment of commonly recommended therapeutic target ranges.
Indirect genetic effects clarify how traits can evolve even when fitness does not
Authors: Fisher David N. , McAdam Andrew G. 
Published: October 2018

AbstractThere are many situations in nature where we expect traits to evolve but not necessarily for mean fitness to increase. However, these scenarios are hard to reconcile simultaneously with Fisher’s Fundamental Theorem of Natural Selection and the Price identity. The consideration of indirect genetic effects on fitness reconciles these fundamental theorems with the observation that traits sometimes evolve without any adaptation, by explicitly considering the correlated evolution of the social environment, which is a form of transmission bias. While transmission bias in the Price identity is often assumed to be absent, here we show that explicitly considering indirect genetic effects as a form of transmission bias for fitness has several benefits: 1) it makes clear how traits can evolve while mean fitness remains stationary, 2) it reconciles the fundamental theorem of natural selection with the evolution of maladaptation, 3) it explicitly includes density-dependent fitness through negative social effects that depend on the number of interacting conspecifics, and 4) its allows mean fitness to evolve even when direct genetic variance in fitness is zero, if related individuals interact and/or if there is multilevel selection. In summary, considering fitness in the context of indirect genetic effects aligns important theorems of natural selection with many situations observed in nature and provides a useful lens through which we might better understand evolution and adaptation.
A practical guide to methods controlling false discoveries in computational biology
Authors: Korthauer Keegan , Kimes Patrick K , Duvallet Claire , Reyes Alejandro , Subramanian Ayshwarya , Teng Mingxiang , Shukla Chinmay , Alm Eric J , Hicks Stephanie C 
Published: October 2018

AbstractBackgroundIn high-throughput studies, hundreds to millions of hypotheses are typically tested. Statistical methods that control the false discovery rate (FDR) have emerged as popular and powerful tools for error rate control. While classic FDR methods use only p-values as input, more modern FDR methods have been shown to increase power by incorporating complementary information as “informative covariates” to prioritize, weight, and group hypotheses. However, there is currently no consensus on how the modern methods compare to one another. We investigated the accuracy, applicability, and ease of use of two classic and six modern FDR-controlling methods by performing a systematic benchmark comparison using simulation studies as well as six case studies in computational biologyResultsMethods that incorporate informative covariates were modestly more powerful than classic approaches, and did not underperform classic approaches, even when the covariate was completely uninformative. The majority of methods were successful at controlling the FDR, with the exception of two modern methods under certain settings. Furthermore, we found the improvement of the modern FDR methods over the classic methods increased with the informativeness of the covariate, total number of hypothesis tests, and proportion of truly non-null hypotheses.ConclusionsModern FDR methods that use an informative covariate provide advantages over classic FDR-controlling procedures, with the relative gain dependent on the application and informativeness of available covariates. We present our findings as a practical guide and provide recommendations to aid researchers in their choice of methods to correct for false discoveries.
The interaction between genotype and maternal nutritional environments affects tomato seed and seedling quality
Authors: Geshnizjani Nafiseh , Khorami Saadat Sarikhani , Willems Leo A.J. , Snoek Basten L. , Hilhorst Henk W.M. , Ligterink Wilco 
Published: October 2018

AbstractSeed and seedling traits are affected by the conditions of the maternal environment, such as light, temperature and nutrient availability. In this study, we have investigated whether different maternally applied nitrate and phosphate concentrations affect the seed and seedling performance of two tomato genotypes:Solanum lycopersicumcv. Money maker andSolanum pimpinellifoliumaccession CGN14498. We observed large differences for seed and seedling traits between the two genotypes. Additionally, we have shown that for nitrate most of the seed and seedling traits were significantly affected by genotype by environment interactions (G×E). The effect of the maternal environment was clearly visible in the primary metabolites of the dry seeds. For example, we could show that the amount of γ-aminobutyric acid (GABA) in Money maker seeds was affected by the differences in the maternal environments and was positively correlated with seed germination under high temperature. Overall, compared to phosphate, nitrate had a larger effect on seed and seedling performance in tomato. In general, the different responses to the maternal environments of the two tomato genotypes show a major role of genotype by environment interactions in shaping seed and seedling traits.HighlightThe presented data specifically provides knowledge towards understanding a multi-level effect of the maternal nutritional environment on seed and seedling characteristics in tomato. We show a clear genotype by environment interactions (G×E) especially for maternal growth on different nitrate concentrations. Additionally we identified metabolites with either positive or negative correlations with maternal environment affected phenotypical traits.
How arbitrary are the weights assigned to books in performance-based research funding? An empirical assessment of the weight and size of monographs in Flanders
Authors: Verleysen Frederik T. , Engels Tim C.E. 
Published: October 2018

Purpose
The purpose of this paper is to present an empirical assessment of the weight assigned to monographs in the publication indicator of the performance-based research funding system (PRFS) in Flanders, Belgium. By relating publication weight to publication size the authors offer an alternative perspective on the production of scholars who publish monographs. This perspective on weights is linked to the aggregation level at which PRFS indicators are used: the national/regional one as opposed to the local one. In Flanders as elsewhere the publication indicator designed for funding distribution between universities has sometimes trickled down to institutions, their faculties and departments.

Design/methodology/approach
As an alternative indicator of scholarly production the authors propose the median number of pages of a publication type. Measuring the size of publications allows to compare the weight ratio between monographs and journal articles in the publication indicator to their size ratio in the VABB-SHW database. The authors compare two levels, one of four universities and one of 16 disciplines.

Findings
Median publication size differences between disciplines are much larger than those between universities. This indicates that an increase of monographs’ weight in the publication indicator would hardly affect funding distribution at the regional level. Disciplines with a relatively large share of monographs, however, would contribute more to the publication indicator. Hence an increase of monographs’ weight might provide a better balance between fields and between publication types.

Originality/value
This paper presents a thought experiment regarding the weight assigned to different publication types in the publication indicator of the Flemish PRFS: what would happen if this weight were replaced by the median number of pages of a publication type? In doing so, we highlight that such weighting schemes play an important role in finding a balance between fields of research. The sizeable differences between weight and size ratios offer a new and critical perspective on the weighting schemes currently used in PRFS, also in other countries.
Are book publications disappearing from scholarly communication in the social sciences and humanities?
Authors: Engels Tim C.E. , Istenič Starčič Andreja , Kulczycki Emanuel , Pölönen Janne , Sivertsen Gunnar 
Published: October 2018

PurposeThe purpose of this paper is to analyze the evolution in terms of shares of scholarly book publications in the social sciences and humanities (SSH) in five European countries, i.e. Flanders (Belgium), Finland, Norway, Poland and Slovenia. In addition to aggregate results for the whole of the social sciences and the humanities, the authors focus on two well-established fields, namely, economics & business and history.Design/methodology/approachComprehensive coverage databases of SSH scholarly output have been set up in Flanders (VABB-SHW), Finland (VIRTA), Norway (NSI), Poland (PBN) and Slovenia (COBISS). These systems allow to trace the shares of monographs and book chapters among the total volume of scholarly publications in each of these countries.FindingsAs expected, the shares of scholarly monographs and book chapters in the humanities and in the social sciences differ considerably between fields of science and between the five countries studied. In economics & business and in history, the results show similar field-based variations as well as country variations. Most year-to-year and overall variation is rather limited. The data presented illustrate that book publishing is not disappearing from an SSH.Research limitations/implicationsThe results presented in this paper illustrate that the polish scholarly evaluation system has influenced scholarly publication patterns considerably, while in the other countries the variations are manifested only slightly. The authors conclude that generalizations like “performance-based research funding systems (PRFS) are bad for book publishing” are flawed. Research evaluation systems need to take book publishing fully into account because of the crucial epistemic and social roles it serves in an SSH.Originality/valueThe authors present data on monographs and book chapters from five comprehensive coverage databases in Europe and analyze the data in view of the debates regarding the perceived detrimental effects of research evaluation systems on scholarly book publishing. The authors show that there is little reason to suspect a dramatic decline of scholarly book publishing in an SSH.
Achieving leanness with BIM-based integrated data management in a built environment project
Authors: Ma Xiaozhi , Chan Albert P.C. , Wu Hengqin , Xiong Feng , Dong Na 
Published: October 2018

Purpose
Although various concepts and techniques are introduced to the built environment to achieve a substantially efficient building production, the effective application of these methods in projects is of immense significance to the field of building construction. Among these initiatives, lean construction and building information modelling (BIM) are mainstream endeavours that share many common principles to improve the productivity of the built environment. This study aims to explore and explain how BIM-based integrated data management (IDM) facilitates the achievement of leanness in a built environment project.

Design/methodology/approach
This research is conducted through an ethnographic-action research that relies on the design-science approach and case study through a collaborative research project. As participants of the project, the researchers of this study cooperate with the practitioners to design the project approach and production workflows. Research data and evidence are obtained via participative observation, including direct observation, results of activities, unstructured meetings and self-analysis.

Findings
In this study, the project and production perspectives clarify the building design and production process, as well as analyse how BIM facilitates the achievement of leanness in building design and construction. BIM-based frameworks for IDM have been developed to handle miscellaneous information and data, as well as enhance multidisciplinary collaboration throughout the project life cycle. The role of the integrated BIM model as an information hub between the building design and building construction has been identified.

Research/limitations implications
The project and production views of building and construction are used in this study because the research purpose is to link the BIM-based IDM to lean construction. Although this mixed approach can slightly undermine the theoretical foundation of this study, a substantially comprehensive understanding can be gained as well.

Practical implications
This study provides a new perspective to understand how BIM-based IDM contributes to lean construction.

Originality/value
This study provides new insights into IDM in a built environment project with project and production views and presents BIM-based frameworks for IDM to achieve lean construction through the BIM process.
Managers’ perceptions of trust in the workplace in times of strategic change
Authors: Komodromos Marcos , Halkias Daphne , Harkiolakis Nicholas 
Published: October 2018

PurposeThe purpose of this paper is to explore and present current trends and developments in the field of managers’ perceptions of trust and the management of change in Cyprus, Greece and Romania, in a period of strategic organizational change. A total of 126 managerial employees (communication managers, operation managers, quality control managers, safety & environmental managers, and office managers) working in different departments of organizations in Cyprus, Greece, and Romania respond and complete the online questionnaire.Design/methodology/approachA qualitative study using an online questionnaire with interview questions was developed to arrive at the study’s findings. To acknowledge relevant perceptions of trust and the management of change during organizational change in different organizations in Cyprus, Greece and Romania, unique questions helped to support the research results and highlight themes that emerged from interview sessions with the study participants.FindingsThe findings highlight the need for organizational leadership to establish mutual trust and effective communication with managerial employees for successful cooperation during times of strategic change and enhanced overall employee performance. This study is relevant for researchers and academics in the areas of change management and communication, presenting current trends and developments in perceptions of trust and change management in Cyprus, Greece and Romania. It may also help them achieve recognition among their peers and colleagues from other disciplines.Research limitations/implicationsAn important implication of the study derives from the finding on the uniqueness of the knowledge and information work carried out by the respondents and the impact that this can have in their working environment and their productivity. As a result of the above, this study provides indications to recruiters and managers regarding a number of desirable and necessary skills, and motivational factors that future employees may need to have or develop in order to carry out their job efficiently and effectively.Practical implicationsResearching managerial employees’ perceptions of trust and the management of change in organizations can have significant implications for human resources management during a time of strategic change.Social implicationsThis research study may contribute to the management and communication area in European countries in stimulating new approaches to management and social issues and in the corporate management practice.Originality/valueThis study produces new knowledge instead of summarizing what is already known in a new form in the area of management and corporate communication. The researcher reports the results in analysis and interprets the results by discussing possible implications and solutions.
Business intelligence and big data in hospitality and tourism: a systematic literature review
Authors: Mariani Marcello , Baggio Rodolfo , Fuchs Matthias , Höepken Wolfram 
Published: October 2018

PurposeThis paper aims to examine the extent to which Business Intelligence and Big Data feature within academic research in hospitality and tourism published until 2016, by identifying research gaps and future developments and designing an agenda for future research.Design/methodology/approachThe study consists of a systematic quantitative literature review of academic articles indexed on the Scopus and Web of Science databases. The articles were reviewed based on the following features: research topic; conceptual and theoretical characterization; sources of data; type of data and size; data collection methods; data analysis techniques; and data reporting and visualization.FindingsFindings indicate an increase in hospitality and tourism management literature applying analytical techniques to large quantities of data. However, this research field is fairly fragmented in scope and limited in methodologies and displays several gaps. A conceptual framework that helps to identify critical business problems and links the domains of business intelligence and big data to tourism and hospitality management and development is missing. Moreover, epistemological dilemmas and consequences for theory development of big data-driven knowledge are still a terra incognita. Last, despite calls for more integration of management and data science, cross-disciplinary collaborations with computer and data scientists are rather episodic and related to specific types of work and research.Research limitations/implicationsThis work is based on academic articles published before 2017; hence, scientific outputs published after the moment of writing have not been included. A rich research agenda is designed.Originality/valueThis study contributes to explore in depth and systematically to what extent hospitality and tourism scholars are aware of and working intendedly on business intelligence and big data. To the best of the authors’ knowledge, it is the first systematic literature review within hospitality and tourism research dealing with business intelligence and big data.
I think someone is walking with me: the use of mobile phone for social capital development among women in four refugee communities
Authors: Koh Lee Cheng , Walker Rae , Wollersheim Dennis , Liamputtong Pranee 
Published: October 2018

Purpose
The purpose of this paper is to present a mixed method study of social capital development and use, based on an intervention which provided women from refugee backgrounds with social capital development skills and tools.

Design/methodology/approach
In total, 111 Afghan, Burmese and Sudanese women living in Melbourne, Australia, received peer-support training and a free unlimited fixed-dial mobile phone for one year.

Findings
Interview and call log data suggest that the training sessions and mobile phones played important roles in bonding social capital development, resulting in a complex support network among participants. To a lesser extent, there was also evidence of bridging social capital creation. By providing linkages to government institutions through an interpreter service, the mobile phones gave participants easy access to linking social capital, in their heritage language.

Originality/value
The program supplements existing community resources with mobile phone technology to create social capital rich networks within these disadvantaged communities, and the authors describe the community characteristics that make participants amenable to such an intervention.
Executing large-scale processes in a blockchain
Authors: Ramkumar Mahalingam 
Published: October 2018

Purpose
The purpose of this paper is to examine the blockchain as a trusted computing platform. Understanding the strengths and limitations of this platform is essential to execute large-scale real-world applications in blockchains.

Design/methodology/approach
This paper proposes several modiﬁcations to conventional blockchain networks to improve the scale and scope of applications.

Findings
Simple modifications to cryptographic protocols for constructing blockchain ledgers, and digital signatures for authentication of transactions, are sufficient to realize a scalable blockchain platform.

Originality/value
The original contributions of this paper are concrete steps to overcome limitations of current blockchain networks.