bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical effects of extracorporeal shock-wave therapy and ultrasound-guided local corticosteroid injections for plantar fasciitis in adults
Authors: Li Shuxiang , Wang Kun , Sun Han , Luo Xiaomin , Wang Peng , Fang Sheng , Chen Haifeng , Sun Xiaoliang 
Published: December 2018

AbstractBackground:The argument on whether extracorporeal shock-wave therapy (ESWT) and corticosteroid injections (CSIs) exert an equivalent pain control or which is the better treatment for plantar fasciitis (PF) in adults remains to be resolved. It is important and necessary to conduct a meta-analysis to make a relatively more credible and overall assessment about which treatment method performs better pain control in treatment of PF in adults.Methods:From the inception to July 2018, the Embase, PubMed, Web of Science, and Cochrane Library electronic databases were searched for all relevant studies. Only randomized controlled trials (RCTs) focusing on comparing ESWT and CSI therapies in PF cases in adults were included. The primary outcome measure was visual analog scale (VAS) reduction, whereas the secondary outcomes included treatment success rate, recurrence rate, function scores, and adverse events.Results:Nine RCTs involving 658 cases were included in this meta-analysis. In the present study, meta-analysis showed that high-intensity ESWT had superior pain relief and success rates relative to the CSI group within 3 months, but the ESWT with low intensity was slightly inferior to CSI for efficacy within 3 months. In addition, patients with CSI may tend to increase the need for the analgesic and more adverse events may be associated with the ESWT. However, the ESWT and CSI present similar recurrent rate and functional outcomes.Conclusion:Our analysis showed that the pain relief and success rates were related to energy intensity levels, with the high-intensity ESWT had the highest probability of being the best treatment within 3 months, followed by CSI, and low-intensity ESWT. More high-quality RCTs with long-term follow-up time are needed to further compare the differences of CSI and ESWT for adults with PF.
Cystic metastasis of prostate cancer
Authors: Zhang Bei , Bian Bingyang , Bi Lirong , Wang Zhuo , Zhao Yang , Wang Jiping 
Published: December 2018

Abstract

Rationale:
Prostate cancer often metastasizes (most commonly to the pelvic lymph nodes and axial skeleton); however, metastases to the pelvic cavity as a solitary mass are unusual. While metastatic prostate cancer is unconventional in pelvic cavity, cystic pelvic lesions are even more scarce. Accurate identification of cystic metastasis can be helpful in management of prostate cancer.

Patient concerns:
A 64-year-old male was admitted to our hospital due to urethral irritation symptom and dysuria.

Diagnosis:
In addition to prostate cancer, abdominal computed tomography (CT) scanning and magnetic resonance imaging (MRI) of the prostate revealed that a cystic mass was located at right pelvic cavity. Histopathological examination diagnosed the pelvic cystic mass as metastasis from prostatic cancer. Immunohistochemistry results demonstrated Calretinin (+), D2-40 (−), Ki-67 (10%+), Vimentin (−), CK-pan (+), CK5/6 (−), WT-1 (−), PSA (+), SALL4 (−), Villin (−), CK20 (−), CK7 (−), PAX-8 (−), and TTF-1 (−).

Interventions:
The cystic mass was removed. Primary cancer of the prostate was reserved as well. After discharge, the patient underwent in a two-year androgen deprivation therapy (ADT) treatment.

Outcomes:
After 13 months of discharge, no disease progression was found in the patient.

Lessons:
Although cystic prostate cancer is rare, the occurrence possibility should be considered when cystic lesions are accompanied with prostate cancer.
Compatibility and stability of dezocine and tropisetron in 0.9% sodium chloride injection for patient-controlled analgesia administration
Authors: Chen Peng , Chen Fuchao , Zhou Ben-hong 
Published: December 2018

Abstract
Tropisetron is an adjuvant for dezocine used in intravenous patient-controlled analgesia (PCA) and has been reported to provide superior pain control. It is efficacious in reducing the institutional incidence of postoperative nausea and vomiting (PONV), which decreases resource utilization and cost. However, no scientific evidence has been reported in the literature demonstrating analytical confirmation of the compatibility and stability of the combination of dezocine and tropisetron. Thus, the present study aimed to investigate the stability of dezocine with tropisetron in 0.9% sodium chloride injection form for PCA administration.
Commercial solutions of dezocine and tropisetron were combined and examined for compatibility and stability when diluted with 0.9% sodium chloride injection in polyolefin bags and glass bottles stored at 4°C or 25°C for up to 14 days. The initial concentrations were 40 mg/100 mL dezocine and 5 mg/100 mL tropisetron. For all samples, the compatibility parameters (including precipitation, cloudiness, discoloration, and pH values) were evaluated. Chemical stability was also determined using high-performance liquid chromatographic (HPLC) analysis.
After a 14-day period of storage at 4°C or 25°C, the initial concentrations of dezocine and tropisetron were maintained at at least 98%. All of the mixtures remained clear and colorless throughout the observation period, and no color change or precipitation was observed.
These results indicated that admixtures of 40 mg/100 mL dezocine and 5 mg/100 mL tropisetron in 0.9% sodium chloride injection were stable for at least 14 days when stored in polyolefin bags or glass bottles at 4°C or 25°C and protected from light.
Efficacy and safety of laparoscopic splenectomy and esophagogastric devascularization for portal hypertension
Authors: Zheng Shunzhen , Sun Ping , Liu Xihan , Li Guangbing , Gong Wei , Liu Jun 
Published: December 2018

Abstract
Many patients in China have portal hypertension secondary to liver cirrhosis. Splenectomy and devascularization have become an efficacious surgical procedure for portal hypertension, and has been recommended in China as the first choice for the treatment of portal hypertension for a long time. As a result of advances in laparoscopic equipment and techniques, splenectomy and esophagogastric devascularization have been carried out with laparoscope.
From January 2012 to December 2017, 453 patients who were diagnosed with portal hypertension and serious gastroesophageal varices received surgical management in our institution. 250 patients chose laparoscopic splenectomy and esophagogastric devascularization and 203 underwent open splenectomy and esophagogastric devascularization.
We retrospectively analyzed the perioperative data and follow-up data of these patients. The operation time of laparoscopic group was longer than open group (P ≤ .001). Intraoperative blood loss was less (P ≤ .001), the passing of flatus was earlier (P = .042), and postoperative hospital stay was shorter (P = .001) in the laparoscopic group. During postoperative follow-up of 4 to 75 months, the incidence of esophagogastric variceal rebleeding, encephalopathy, and secondary liver cancer showed no significant differences.
Laparoscopic splenectomy and esophagogastric devascularization were safe and more effective than open surgery for portal hypertension and gastroesophageal varices.
Diagnostic value of 18F-fluorodeoxyglucose positron-emission tomography/computed tomography for preoperative lymph node metastasis of esophageal cancer
Authors: Hu Jingfeng , Zhu Dengyan , Yang Yang 
Published: December 2018

Abstract

Objective:
We determined the value of 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (18FDG PET/CT) for the assessment of preoperative lymph node metastases in patients with esophageal cancer.

Methods:
We searched electronic database indexes for articles on PET/CT assessment of lymph node status. Information including true positives, false positives, false negatives, and true negatives was obtained. Based on these data, the pooled sensitivity, specificity, diagnostic odds ratio, and likelihood ratio were calculated using bivariate models and receiver operating characteristic curves (ROCs) were drawn.

Results:
Patients without neoadjuvant treatment had a pooled sensitivity and specificity (95% confidence interval [CI]) of 0.57 (0.45–0.69) and 0.91 (0.85–0.95), respectively. Patients who received neoadjuvant treatment had a pooled sensitivity and specificity of 0.53 (0.35–0.70) and 0.96 (0.86–0.99), respectively.

Conclusions:
The PET/CT has a high diagnostic specificity but its diagnostic sensitivity is low; thus, its diagnosis findings cannot accurately reflect the lymph node status.
A chronic sinus tract infection developing after suture anchoring of the ankle
Authors: Kim Woo Jong , Young Ki Won , Kim Chang Hyun , Won Sung Hun , Bae Kyu Hwan , Lee Hong Seop 
Published: December 2018

Abstract

Rationale:
Suture anchors are increasingly used to fix soft tissue to bone. Favorable outcomes of the modified Brostrom operation (MBO) using suture anchors have been reported. However, to the best of our knowledge, few complications of suture anchors used in ankle surgery have been described. Here, we present a rare case of successful treatment of a chronic sinus tract infection developing after the MBO using a suture anchor.

Patient concerns:
A healthy 18-year-old high school student presented with a chronic ulcerative wound in his right ankle 1 year after anterior talofibular and calcaneofibular ligament repair using a suture anchor at a local clinic. Clinical examination revealed a 1.5 × 2-cm-sized ulcerative wound, accompanied by a red-black discharge, on the anterior border of the right lateral malleolus. The wound could be approximated to the joint capsule level using a forceps.

Diagnosis:
A simple standing anteroposterior radiograph of the right ankle revealed mild, lateral soft-tissue swelling. Magnetic resonance imaging showed that a sinus tract running from the wound to the talar body crossed the anterior joint capsule, and bone marrow edema surrounding the talus.

Interventions:
We removed the sinus tract and the infected suture anchor. We rendered the wound zigzag-shaped and then performed simple suturing and applied a short leg cast.

Outcomes:
The wound healed completely by 4 weeks after surgery. The patient reported no complication or recurrence of infection at the 1-year follow-up.

Lessons:
To obtain wound healing, the chronic sinus tract must be removed. If the suture anchor is the cause of infection, it should be removed.
A case report: Co-occurrence of Wilson disease and oculocutaneous albinism in a Chinese patient
Authors: Rao Rao , Shu Shan , Han Yong Zhu , Chiu Yu-Jen , Han Yong Sheng 
Published: December 2018

Abstract

Rationale:
Both Wilson disease (WD) and Oculocutaneous Albinism (OCA) are rare autosomal recessive disorders that are caused by mutations on chromosome 13 and chromosome 11, respectively. Here, we report on a patient with coexisting WD and OCA, initially presenting episodes of tremors.

Patient concerns:
WD is a disorder of copper metabolism. The main sites of copper accumulation are the liver and the brain, resulting in hepatic symptoms. OCA is a disorder of melanin biosynthesis, characterized by a generalized reduction in pigmentation of the eyes (oculo-), skin (-cutaneous), and hair.
Diagnosis: The diagnosis of WD was confirmed by neurological symptoms, metabolism tests, and MRI scans. Interestingly, the patient also had very light skin color, blond hair and eyebrows, and dark brown eyelashes and irises. Because the association of dermatologic signs in WD has rarely been reported, OCA was highly suspected based on these clinical findings. Genetic analysis was subsequently conducted, and the results revealed the p. (Arg778Leu) mutation in 1 allele and the p. (Asn1270Ser) mutation in the other allele of the ATP7B gene, confirming the diagnosis of WD; the p. (D456fs) mutation in 1 allele and the p. (R299H) mutation in the other allele of the TYR gene, confirming the diagnosis of OCA. The family history was positive for WD with a 14-year-old younger brother also being diagnosed with it. Her parents are negative for OCA and WD.

Interventions:
Sodium dimercaptopropanesulfonate (DMPS) was given during hospitalization. D-penicillamine and zinc sulfate treatment was initiated after discharge for long-term control.

Outcomes:
Postural and intention tremor disappeared, and other symptoms and signs markedly improved after treatment.

Lessons:
In this study, we reported on the first case of a child who simultaneously presented WD and OCA, bringing up the possibility of a presumable link between these 2 rare diseases.
Psychometric Evaluation of an Instrument to Measure Prospective Pregnancy Preferences
Authors: Rocca Corinne H. , Ralph Lauren J. , Wilson Mark , Gould Heather , Foster Diana G. 
Published: December 2018

Background:
Existing approaches to measuring women’s pregnancy intentions suffer important limitations, including retrospective assessment, overly simple categories, and a presumption that all women plan pregnancies. No psychometrically valid scales exist to prospectively measure the ranges of women’s pregnancy preferences.

Materials and Methods:
Using a rigorous construct modeling approach, we developed a scale to measure desire to avoid pregnancy. We developed 60 draft items from existing research, assessed comprehension through 25 cognitive interviews, and administered items in surveys with 594 nonpregnant women in 7 primary and reproductive health care facilities in Arizona, New Jersey, New Mexico, South Carolina, and Texas in 2016–2017. We used item response theory to reduce the item set and assess the scale’s reliability, internal structure validity, and external validity. Items were included based on fit to a random effects multinomial logistic regression model (partial credit item response model), correspondence of item difficulty with participants’ pregnancy preference levels, and consistency of each item’s response options with overall scale scores.

Results:
The 14 final items covered 3 conceptual domains: cognitive preferences, affective feelings, and practical consequences. Items fit the unidimensional model, with a separation reliability of 0.90 (Cronbach α: 0.95). The scale met established criteria for internal validity, including correspondence between each item’s response categories and overall scale scores. We found no important differential item functioning by participant characteristics.

Conclusions:
A robust measure is available to prospectively measure desire to avoid pregnancy. The measure can aid in identifying women who could benefit from contraceptive care and research on less desired pregnancy.
Impact of Patient Safety Culture on Missed Nursing Care and Adverse Patient Events
Authors: Hessels Amanda J. , Paliwal Mani , Weaver Susan H. , Siddiqui Deeba , Wurmser Theresa A. 
Published: December 2018

Background:
A strong patient safety culture (PSC) may be associated with improved patient outcomes in hospitals. The mechanism that explains this relationship is underexplored; missed nursing care may be an important link.

Purpose:
The purpose of this study was to describe relationships among PSC, missed nursing care, and 4 types of adverse patient events.

Methods:
This cross-sectional study employed primary survey data from 311 nurses from 29 units in 5 hospitals and secondary adverse event data from those same units. Analyses include analysis of variance and regression models.

Results:
Missed nursing care was reported to occur at an occasional level (M = 3.44, SD = 0.24) across all 29 units. The PSC dimensions explained up to 30% of the variance in missed nursing care, 26% of quality of care concerns, and 15% of vascular access device events. Missed care was associated with falls (P < .05).

Conclusions:
Prioritized actions to enhance PSC should be taken to reduce missed nursing care and adverse patient outcomes.
Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women: A Systematic Review and Meta-analysis
Authors: Clarke Megan A. , Long Beverly J. , Del Mar Morillo Arena , Arbyn Marc , Bakkum-Gamez Jamie N. , Wentzensen Nicolas 
Published: December 2018

(Abstracted from JAMA Intern Med 2018;178:1210–1222)
The incidence of endometrial cancer and deaths from this cancer has increased in recent years and is projected to rise over the next decade.
Subchorionic Hematoma: Correlation of Grading Techniques With First-Trimester Pregnancy Outcome
Authors: Heller Howard T. , Asch Elizabeth A. , Durfee Sara M. , Goldenson Robin P. , Peters Hope E. , Ginsburg Elizabeth S. , Doubilet Peter M. , Benson Carol B. 
Published: December 2018

(Abstracted from J Ultrasound Med 2018;37:1725–1732)
A common finding on early first-trimester ultrasound (US) examinations, subchorionic hematoma (SCH) occurs in both asymptomatic patients and those presenting with vaginal bleeding. Previous studies assessing the risk of first-trimester pregnancy failure when an SCH is seen on an early pregnancy sonogram have used a variety of grading systems for characterizing the size of the hematoma, including subjective grading of the SCH as small, moderate, or large; calculating the volume of the SCH from its US measurements; estimation of hematoma size as a fraction of gestational sac size; and estimated fraction of the gestational sac that is surrounded by hematoma.
Prenatal Counseling and Parental Decision-Making Following a Fetal Diagnosis of Trisomy 13 or 18
Authors: Winn Phoebe , Acharya Krishna , Peterson Erika , Leuthner Steven 
Published: December 2018

(Abstracted from J Perinatol 2018;38:788–796)
Trisomy 13 (T13) and 18 (T18) are chromosomal anomalies that have historically been considered lethal, but this notion has been questioned within the last decade by physicians, ethicists, and families. The literature has focused on the commonly described negative parental experience of prenatal and neonatal counseling and the extent of medical and surgical interventions that children with these conditions receive, their survival, and neurodevelopmental outcomes.
Sexual Response in Women With Mayer-Rokitansky-Küster-Hauser Syndrome With a Nonsurgical Neovagina
Authors: Both Stephanie , Kluivers Kirsten , ten Kate-Booij Marianne , Weijenborg Philomeen 
Published: December 2018

(Abstracted from Am J Obstet Gynecol 2018;219:283.e1–283.e8)
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is an uncommon congenital condition characterized by an agenesis or hypoplasia of vagina and uterus. The first-line treatment approach—nononsurgical vaginal elongation by dilation—has high success rates (90%–96%).
Single cell RNA-Seq reveals distinct stem cell populations that drive sensory hair cell regeneration in response to loss of Fgf and Notch signaling
Authors: Lush Mark E. , Diaz Daniel C. , Koenecke Nina , Baek Sungmin , Boldt Helena , St. Peter Madeleine K. , Gaitan-Escudero Tatiana , Romero-Carvajal Andres , Busch-Nentwich Elisabeth M. , Perera Anoja , Hall Kate , Peak Allison , Haug Jeffrey S. , Piotrowski Tatjana 
Published: December 2018

AbstractLoss of sensory hair cells leads to deafness and balance deficiencies. In contrast to mammalian hair cells, zebrafish ear and lateral line hair cells regenerate from poorly characterized, proliferating support cells. Equally ill-defined is the gene regulatory network underlying the progression of support cells to cycling hair cell progenitors and differentiated hair cells. We used single cell RNA-Sequencing (scRNA-Seq) of lateral line sensory organs and uncovered five different support cell types, including quiescent and activated stem cells.In silicoordering of support cells along a developmental trajectory identified cells that self-renew and new groups of genes required for hair cell differentiation. scRNA-Seq analyses offgf3mutants, in which hair cell regeneration is increased, demonstrates that Fgf and Notch signaling inhibit proliferation of support cells in parallel by inhibiting Wnt signaling. Our scRNA-Seq analyses set the foundation for mechanistic studies of sensory organ regeneration and is crucial for identifying factors to trigger hair cell production in mammals. As a resource, we implemented a shiny application that allows the community to interrogate cell type specific expression of genes of interest.
Do elderly breast cancer patients have poorer survival outcome?
Authors: Suen Dacita To‐Ki , You Ka‐Po , Luk Wing‐Pan , Fung Ling‐Hiu , Kwong Ava 
Published: December 2018

AimThe aim of the present study was to compare breast cancer in elderly patients to their younger counterparts, and look for factors affecting the survival of elderly patients.Patients and MethodsA retrospective study of breast cancer patients who had surgery at a university hospital from 2000 to 2015 was performed. Stage on presentation, tumour characteristics and modalities of treatment for patients aged >70 years were compared with those aged <70 years. Factors affecting breast cancer specific survival were assessed by multivariate Cox regression.ResultsIn total, 3825 patients with breast cancer underwent surgery during the study period; 510 patients (13.3 per cent) were aged >70 years . The 5‐year overall survival for elderly patients was 76.9 per cent, which was poorer than their younger counterparts (89.5 per cent, P = 0.000). Multivariate analysis demonstrated that the use of adjuvant hormonal therapy (P = 0.001, hazard ratio: 0.481), advanced T‐stage (P < 0.05) and advanced N‐stage (P < 0.001) were the independent factors affecting breast cancer‐specific survival in elderly patients.ConclusionsElderly breast cancer patients had worse overall and breast cancer‐specific survival. Stage on presentation and the use of adjuvant hormonal therapy were independent factors affecting survival among elderly patients. Early diagnosis and comprehensive geriatric assessment to guide the optimal treatment plan would be useful for better survival outcomes in elderly breast cancer patients.
Cumulative impact: Why prison sentences have increased*
Authors: King Ryan D. 
Published: December 2018

AbstractWhy has the probability of going to prison after a felony conviction increased since the early 1980s? Social scientists often try to answer this question through macro‐level research that is aimed at examining correlations between prison admissions and crime rates or sociopolitical characteristics of states. That type of macro‐level inquiry, however, does not allow for a close examination of how characteristics of offenders changed over time, and whether such changes are consequential for understanding trends in the use of imprisonment. In the current study, I take a different approach—one in which case‐level data are observed over a lengthy time span—to investigate why the likelihood of going to prison for a given crime persistently increased for several decades. The results of analyses of more than 350,000 felony cases sentenced in Minnesota during a 33‐year period show that the probability of a defendant receiving a prison sentence increased from 1981 to 2013, as would be expected. The primary reason for the rising probability of imprisonment was the significant increase in the average offender's criminal record, which more than doubled during the observation period.