bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between family income to poverty ratio and severe headache/migraine in the American adults: data from NHANES 1999–2004
Authors: Sun Lingling , Zhao Rongjian , You Xuemei , Meng Junpeng , Meng Lin , Di Haili 
Published: November 2024

BackgroundThe relationship between family income to poverty ratio (PIR) and severe headache/migraine remains unclear.MethodsData for this cross-sectional study were obtained from NHANES 1999–2004. PIR was the exposure variable, and severe headache/migraine was the dependent variable. We performed univariate analyses of severe headache/migraine, PIR, and other covariates. The association between PIR and severe headache/migraine was tested using multiple regression models. Furthermore, interaction tests and stratified analyses assessed the relationship between PIR and severe headache/migraine across subgroups.ResultsThere were a total of 8,800 participants: 4,833 (54.92%) males and 3,967 (45.08%) females, 1,714 (19.48%) with severe headache/migraine and 7,086 (80.52%) without severe headache/migraine. After adjustment for all variables, PIR negatively correlated with severe headache/migraine OR = 0.86 95% CI (0.83, 0.90) p &lt; 0.0001. The variable PIR was categorized as the low-income (PIR &lt; 1), the middle-income (PIR1-4), and the high-income (PIR &gt; 4). Notably, there was a significant difference in trend for the high-income group (PIR &gt; 4) compared to the control low-income group (PIR &lt; 1) (all P for interaction&lt;0.05). Dose–response correlations were also analyzed using smoothed curve fitting, revealing a negative correlation between PIR and severe headache/migraine (p &lt; 0.0001). Subgroup analysis results indicated that the negative association between PIR and severe headache/migraine was more pronounced in the following populations: males (OR = 0.84 95% CI (0.79, 0.90), &lt;60 years old [Age &lt; 45 group OR = 0.81 95% CI (0.76, 0.85)], Age 45–60 group OR = 0.86 95% CI (0.79, 0.93), and those with education levels ≥high school [High School OR = 0.87 95% CI (0.81, 0.95), &gt;High School OR = 0.82 95% CI (0.78, 0.87)].ConclusionThere is a negative correlation between PIR and the incidence of severe headaches/ migraine in Americans aged 20 years or older. This study has implications for the comprehensive management of patients with severe headache/migraine.
Aminotransferase-to-lymphocyte ratio as a valuable prognostic marker for patients with stage I-III colorectal cancer: a retrospective study
Authors: Xie Hailun , Wei Lishuang , Tang Shuangyi , Gan Jialiang 
Published: November 2024

BackgroundThere are no population-based studies on the prognostic value of the preoperative aminotransferase-to-lymphocyte ratio (AALR) in predicting recurrence and survival in patients with colorectal cancer (CRC) who have undergone curative resection.AimThis study explored the relationship between AALR and prognosis of CRC patients, specifically stage III CRC.MethodsRestricted Cubic Splines were used to evaluate the relationship between AALR and outcomes. The survival curve was generated using the Kaplan-Meier method and the log-rank test. COX regression analysis was used to identify the independent prognostic factors of CRC patients. Logistic regression analysis was used to assess the independent risk factors affecting sarcopenia and postoperative complications. Concordance index and calibration curves were used to evaluate the discriminative ability of the prognostic nomograms. Finally, according to a ratio of 7:3, the total population was randomized into two cohorts to validate the practicability of the prognostic nomograms.ResultsIn total, 1304 stage I-III CRC were enrolled in this study. There was a significant positive correlation between AALR and PFS/OS in CRC patients. The PFS/OS ratio of the high AALR group was significantly lower than that of the low AALR group. In the subgroup analysis, we found that the AALR significantly stratified the prognosis of patients with stage III CRC. A high AALR was still independently associated with poor PFS (HR = 1.335, 95% CI =1.075–1.657, p=0.009) and OS (HR = 1.382, 95% CI =1.139–1.677, p=0.001) in CRC patients. Variables with a value ≤ 0.05 in multivariable analysis were incorporated into the construction of prognostic nomograms for predicting 1-5 years PFS/OS of CRC patients. The results of the concordance index and calibration curves confirmed that these prognostic nomograms had a good prediction accuracy. In addition, we demonstrated the good predictive performance of these nomograms in a randomized internal validation cohort.ConclusionAALR is an effective prognostic marker for predicting long-term outcomes and could provide a valuable reference for sarcopenia and postoperative complications in CRC patients. AALR-based nomograms have good predictive accuracy and can help to develop individualized risk stratification, follow-up, and treatment strategies for CRC patients.
Classifying chronic pain using ICD-11 and questionnaires—reported characteristics in Japanese patients with chronic pain
Authors: Igari Hiroki , Aono Shuichi , Bu-Omer Hani M. , Kishimoto Chie , Nakae Aya , Ushida Takahiro 
Published: November 2024

IntroductionThe new ICD-11 code for chronic pain indicates a direction to divide chronic pain into two categories: chronic secondary pain, which has a clear underlying disease, and chronic primary pain, which is associated with significant emotional distress or functional disability and cannot be explained by another chronic condition. Until now, epidemiological studies have been hampered by the lack of a clear classification, but we believe that this new code system will provide a new perspective on the diagnosis and treatment of chronic pain, and we have begun work on this code system.MethodsWe studied 2,360 patients at Aichi Medical University, the largest pain center in Japan, and asked them to answer questionnaires on pain severity (NRS), pain-related functional impairment (PDAS, Locomo25), quality of life (EQ-5D), and psychological state and pain cognition (HADS, PCS, PSEQ, AIS) while their attending physicians were giving diagnoses according to ICD-11 and the results of the study were used to determine the coding of pain severity.Results and discussionThe ratio of primary to chronic secondary pain was almost 50%, and the group of patients with MG30.01 classification, which included fibromyalgia, had the highest severity among chronic primary pain. The MG30.01 classification of patients was also found to experience more severe pain compared to other classifications of chronic primary pain patients. The classification of patients with a major psychiatric component was not always clear, and some patients in the secondary category also had a clear psychiatric component, suggesting the need to develop complementary tools to support pain diagnosis.
Reconstruction of radial deviation after preaxial polydactyly surgery: use of an ulnar fascial flap
Authors: Chen Hua , Wu Kang , Wang Hongrui , Hu Yong , Wang Yang 
Published: November 2024

BackgroundRadial deviation of the interphalangeal (IP) joint is a common complication of treating Wassel type IV-D preaxial polydactyly. Long-term radial deviation can place excessive tension on the radial skin and cause overabundance of the ulnar skin. To overcome this problem, we aimed to utilize a fascial flap for ulnar reconstruction of a defect in the radial skin.MethodsWe used a fascial flap for ulnar reconstruction of a defect in the radial skin, eight patients (average: 12 years, range: 5–33 years) who underwent reconstructive surgery at our department for radial deviation of the interphalangeal (IP) joint after the initial operation were included between August 2017 and August 2021. An incision was made on the radial side of the thumb. An olive-shaped flap was designed on the ulnar eminence of the IP joint. The skin and fascia in the other three quadrants were incised. While the flap was protected, children with epiphyseal plates underwent wedge osteotomy at the maximum ulnar deviation of the proximal phalanx, and adults underwent direct fusion of the distal IP joint. Absorbable sutures were used to suture the flap. The Tada functional and visual analog scale (VAS) scores were recorded before and after the operation.ResultsAll flaps survived without infection or necrosis. The preoperative and postoperative Tada scores were 1 and 5, respectively, and the preoperative and postoperative VAS scores were 3 and 9, respectively. The postoperative scores showed a statistically significant degree of improvement.ConclusionsAn ulnar fascial flap is an effective and feasible option for repair of radial deviation following surgery for preaxial polydactyly.
Investigation on regulation of N-acetyltransferase 2 expression by nuclear receptors in human hepatocytes
Authors: Hong Kyung U. , Aureliano Anthony P. , Walls Kennedy M. , Hein David W. 
Published: November 2024

IntroductionArylamine N-acetyltransferase 2 (NAT2) expresses a well-defined genetic polymorphism in humans that modifies drug and xenobiotic metabolism. Recent studies and genome wide association studies have reported that genetic variants of NAT2 are associated with differential risks of developing dyslipidemia and cardiometabolic disorders, suggesting a previously unrecognized role of NAT2 in pathophysiology of metabolic disorders. In support of this notion, we recently showed that human NAT2 expression is differentially regulated by glucose and insulin. Moreover, our in silico analysis showed that NAT2 is co-expressed with nuclear receptors enriched in the liver, e.g., NR1H4 (FXR) and NR1I2 (PXR), that have been previously implicated in regulation of hepatic glucose and lipid homeostasis. Identification of transcriptional regulator(s) of human NAT2 would aid in understanding novel functions that it may play in the liver. Thus, the present study was designed to investigate if NAT2 is transcriptionally regulated by hepatic nuclear receptors.MethodsTo test this, we treated cryopreserved human hepatocytes with agonists towards four different hepatic transcription factors/nuclear hormone receptors, namely FXR (NR1H4), PXR (NR1I2), LXR (NR1H3), and PPARα (PPARA), and measured their effects on the level of NAT2 mRNA.ResultsWhile the treatment with a FXR, PXR, or LXR agonist (i.e., GW-4064, SR-12813, or GW-3965) significantly induced their respective target genes, treatment with these agonists did not significantly alter the transcript level of NAT2 in human hepatocytes. PPARα agonist, GW-7647, treatment resulted in a statistically significant decrease in the NAT2 transcript level. However, its magnitude was marginal.ConclusionIn summary, hepatic nuclear receptors we examined in the present study (FXR, PXR, LXR, and PPARα) did not significantly alter NAT2 expression in cryopreserved human hepatocytes. Additional studies are needed to identify transcriptional regulators of hepatic NAT2 expression.
Naturalistic generative narratives reveal effects of social characteristics on decision-making
Authors: Wong Ethan , Williams Ofir , Williams Ziv M. , Báez-Mendoza Raymundo 
Published: November 2024

IntroductionThe social characteristics of others can powerfully influence our decisions. They can also be broadly impacted by the social context in which these choices are made, making the effects of these characteristics on decision-making especially challenging to understand.MethodsHere, we developed a Generative Narrative Survey that provided participants with naturalistic scenarios that richly varied in social context and theme but that also systematically varied the characteristics of the social agents involved, followed by a question. An example of this narrative is “You’re a tourist, and you are trying to take a picture of yourself with your phone. A black male comes up to you and offers to take the photo for you. Do you hand them your phone?”ResultsAfter validating this approach using feeling thermometer measures, we found that the emotional states of others had the strongest and most consistent effect on the participants’ choices. More notably, whereas most characteristics had independent effects on decision-making, social features such as the inferred socioeconomic status of others significantly influenced the effect that race had on the participant’s judgments. Moreover, the social context of the agent’s interactions with other agents had a significant additive effect, especially when the emotional states of the agents in the scenarios contrasted. The influence of these characteristics on the participants’ choices was also markedly affected by their demographics, especially when contrasting with that of the agents involved, and were often driven by the participants’ reported political views.DiscussionTogether, these findings reveal how the mixture of social characteristics, context, and personal views influence decision-making and highlight the use of naturalistic generative narrative surveys in studying human behavior.
Association of evening chronotype, sleep quality and cognitive impairment in patients with major depressive disorder
Authors: Wang Li , Huo Yingchao , Yao Lihua , Zhang Nan , Ma Simeng , Nie Zhaowen , Wang Wei , Zhou Enqi , Xu Shunsheng , Weng Shenhong , Xiang Dan , Hu Maolin , Liu Zhongchun 
Published: November 2024

ObjectiveThis study aimed to investigate the independent or synergistic effects of evening chronotype and poor sleep quality on cognitive impairment in patients with major depressive disorder (MDD).MethodsA cross-sectional study was conducted on 249 individuals diagnosed with MDD, recruited from the Mental Health Center of Renmin Hospital of Wuhan University. Chronotype preference was assessed using the reduced Horne and Ostberg Morningness - Eveningness Questionnaire (rMEQ), while sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI). Cognitive function was evaluated through the Digit Symbol Substitution Test (DSST), defining impairment as a DSST score ≤ 56 (the lowest quartile of the cohort). Univariate analysis and logistic regression models were employed to explore the factors associated with cognitive impairment, focusing on the potential interactive effects of evening chronotype and poor sleep quality.ResultsOf the 249 subjects recruited, about 41% were classified as evening chronotype. These individuals exhibited poorer sleep quality and more severe depressive symptoms compared to non-evening chronotype (p &lt; 0.01). Univariate analysis revealed that first episode status, Hamilton Depression Rating Scale (HAMD-17) scores, evening chronotype, and poor sleep quality were significantly associated with cognitive impairment (p &lt; 0.05). Multivariate logistic regression analysis further demonstrated that the co-existence of evening chronotype and poor sleep quality significantly increased the likelihood of cognitive impairment (adjusted odds ratio [AdjOR] = 2.65, 95% confidence interval [CI] = 1.09–6.45, p &lt; 0.05).ConclusionOur findings suggest that evening chronotype, poor sleep quality, and their interaction are important contributors to cognitive impairment in patients with MDD, alongside the severity of depression and first episode status. These results emphasize the need for integrated approaches targeting circadian rhythm disruptions and sleep disturbances in the treatment of cognitive dysfunction in MDD.
Project SCOPE: a National Training Initiative to improve capacity of providers to support children impacted by prenatal opioid exposure using the ECHO model™
Authors: Weber Stephanie , Hardesty Canyon , Witwer Andrea , Dahl Ethan , Bush Elsie , Thomas Jessy , Baker Tai , Dudley Ally , Moody Eric J. 
Published: November 2024

IntroductionNeonatal abstinence syndrome (NAS) is a complex condition resulting from prenatal substance exposure that has become increasingly prevalent as a result of the opioid epidemic. NAS can lead to long-term developmental challenges. Interdisciplinary teams with experience working with children with disabilities that focus on social determinants of health can be effective at supporting families affected by NAS. Unfortunately, interdisciplinary teams often lack sufficient training, ongoing practice support, and public health policies to support these families. The objective of this project was to determine the feasibility and impact of a National Training Initiative, called Project SCOPE, to improve the capacity of providers to address the needs of children with NAS and their families.MethodsFourteen (14) sites were trained to fidelity in the ECHO model and SCOPE curriculum, and then each team implemented this model for at least one, eight to 12 session series between 2019–2022. The reach, impact, satisfaction, and intention to implement the model were assessed from administrative records, pre/post surveys, and post-session evaluations.ResultsSCOPE state teams delivered the curriculum to 9,392 individuals across 33 US states. Surveys from 2,197 individuals were used for analysis. Most participants (84%) had previous training in trauma informed care, but only 53% had any training on the NAS or the opioid crisis' impact on children. Satisfaction with SCOPE sessions was high (96.4%), and there was a statistically significant increase of self-reported knowledge change from pre- to post-SCOPE. Over 94% reported their skills increased because of participation. Over 97% of participants indicated their motivation to work with this population increased from SCOPE participation and that they could successfully apply what they learned. Almost 70% reported they were “very” or “extremely” likely to use their new skills.DiscussionProject SCOPE is a highly effective and impactful model that can radically improve capacity to support children affected by the opioid epidemic, thereby increasing the capacity of our healthcare system to respond to this epidemic. Moreover, this model can be rapidly deployed and reach a wide geographic region, especially areas that are affected by the opioid crisis and underserved rural communities.
The African American Dementia and Aging Project: an Oregon-based longitudinal study
Authors: Lindauer Allison , Croff Raina , Duff Kevin , Mattek Nora , Fuller Patrice , Pierce Aimee , Bonds Johnson Kalisha , Kaye Jeffrey 
Published: November 2024

IntroductionThe vast majority of studies on aging, cognition, and dementia focus on non-Hispanic white subjects. This paper adds to the extant literature by providing insight into the African American aging experience. Here we describe the study design and baseline characteristics of the African American Dementia and Aging Project (AADAPt) study, which is exploring aging and cognition in African American older adults in Oregon.MethodsAfrican American older adults (n = 177) participated in AADAPt, a longitudinal study that collected data on cognitive, physical, and social functioning in annual visits since 2000.ResultsAADAPt participants had risk factors for developing dementia in future, such as hypertension and hyperlipidemia, but also reported protective factors such as high social engagement.DiscussionThe AADAPt project offers new insights into aging in older African Americans that includes data on cognition, social engagement, and physical health, which are crucial for understanding the experience of under-represented groups and making future studies more inclusive.
Promoting equity in adolescent health in Latin America: designing a comprehensive Sex education program using Intervention Mapping. A mixed methods study
Authors: Torres-Cortés Betzabé , Leiva Loreto , Canenguez Katia M. , Greaves Lorraine 
Published: November 2024

IntroductionImplementing sex education programs during adolescence is crucial for addressing the risks associated with sexuality. However, some of these interventions lack proper incorporation of a gender perspective and maintain a heteronormative and biologically-focused approach, potentially resulting in inequitable outcomes for adolescents. In response, comprehensive sex education is most effective due to its multidimensional view of sexuality. However, integrating a comprehensive perspective on sexuality and a gender lens that contributes to adolescent health equity presents challenges, especially in low and middle-income countries. This study aimed to develop a comprehensive and gender-transformative sex education program for adolescents in a middle-income country of Latin America, utilizing the Intervention Mapping Approach.MethodsThis exploratory sequential mixed-method study comprised two phases. In the first phase, a literature review, nine focus groups with high school students, and 14 interviews with school professionals were conducted to inform program design. Subsequently, the program underwent validation through expert judgment. In the second phase—as part of program development—a preliminary evaluation was conducted by implementing the program in two high schools with 30 students from public high schools, who were administered a pre-post ad hoc survey.ResultsA comprehensive and gender-transformative sex education program was designed based on literature review findings and input from students and school workers. The ad hoc survey revealed a statistically significant increase in protective skills in sexuality (W = 59, p = .01) among all participants.DiscussionDesigning a sex education intervention through Intervention Mapping allowed for the integration of evidence and the needs of the target population. The results of the preliminary evaluation suggest the potential of the developed program to enhance protective skills in sexuality and promote health equity through gender-equitable outcomes in adolescent sex education.
Remote estimation of leaf nitrogen content, leaf area, and berry yield in wild blueberries
Authors: Anku Kenneth Eteme , Percival David C. , Lada Rajasekaran , Heung Brandon , Vankoughnett Mathew 
Published: November 2024

Nitrogen (N) fertilization is a major management requirement for wild blueberry fields. Its presence and estimation can be difficult given the perennial and heterogeneous nature of the plant, low N requirement, and residual N effects, resulting in the frequent over-application of N, excessive canopy growth, and resulting reduction in berry yields. Therefore, this study aimed to estimate nitrogen content and growth parameters using remote sensing approaches. Three trials were established in three commercial fields in Nova Scotia, Canada. An RCBD with 5 replicates and a plot size of 6 × 8 m with a 2 m buffer was used. Treatments consisted of 0, 20, 40, 60, and 100 kg N ha-1 of fertilizer. Using a DJI Matrice 300 UAV mounted with an RGB and a multispectral camera, aerial measurements were collected at 30 m altitude. Several field measurements including leaf nitrogen content (LNC), leaf area, floral bud numbers, stem height, and yield were conducted. Several vegetation indices (VIs) were computed for each plot, and correlation and regression analyses were conducted. Results indicated that treatments with high nitrogen rates had correspondingly high LAI measurements with the 60 kg ha-1 rate achieving the best growth parameters compared to the other treatments. LNC, LAI, and berry yield estimations using VIs [green leaf index (GLI), green red vegetation index (GRVI), and visible atmospheric red index (VARI)] produced significantly positive R2 values of 0.43, 0.48, and 0.30 respectively. Results from this study illustrated the potential of using VIs to estimate LNC, LAI, and berry yield parameters. It was established that the near-infrared VIs are the most effective in estimating differences in nitrogen rates, making them suitable for use in prescription maps for N fertilization applications.