bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bodily distress syndrome after receiving vaccines: A case report
Authors: Iwata Kentaro , Katsuda Yoshiaki 
Published: June 2019

AbstractA 48‐year‐old woman presented with various symptoms, including widespread body pains, insomnia, palpitations, and shortness of breath, after receiving tetanus toxoid. After going through multiple visits to clinicians of various subspecialties, she was referred to our infectious diseases clinic. She was diagnosed with bodily distress syndrome (BDS), possibly triggered by tetanus toxoid injection. Her symptoms improved shortly after reassurance and medical management. Functional disorders such as BDS can occur after vaccinations, and one must be aware of this possibility in patients with multiple symptoms after receiving vaccines.
Prevalence of hepatitis B and C virus infections in hemodialysis patients in Vietnam: A systematic review and meta‐analysis
Authors: Duong Minh C , Nguyen Van T T , Otsu Satoko , McLaws Mary‐Louise 
Published: June 2019

Background and AimChronic hemodialysis patients are at high risk of contracting hepatitis B (HBV) and C (HCV) virus infections. In Vietnam, the seroprevalence of HBV and HCV infections is approximately 10 and 4%, respectively. Although the chronic hemodialysis population is increasing, relatively little epidemiology is available for HBV and HCV infections in this population. To address this, we reviewed the current literature on the magnitude of these infections in the hemodialysis population in Vietnam.MethodsFour databases were used to search for publications containing the prevalence of HBV and/or HCV infections in hemodialysis patients in Vietnam. Grey literature search was utilized to identify local publications. Prevalence and 95% confidence interval were used or calculated, and a meta‐analysis was conducted on HBV and HCV prevalence for comparison.ResultsSixteen studies were included in the review. The search identified knowledge gaps in the current literature. Available data show that HBV and HCV infections remain prevalent in the hemodialysis population. HBV prevalence is not different between the north and the south of Vietnam. The pattern of HCV prevalence is different, with recent reports of lower prevalence in the south than in the north, while HCV prevalence varies between hemodialysis units in the same regions.ConclusionsA national prevalence survey of hemodialysis patients would improve the reliability and generalizability of the findings. However, the review confirmed that both HBV and HCV were prevalent in hemodialysis patients. The findings support a reinforcement of infection prevention to minimize the risk of HBV and HCV transmission in hemodialysis facilities.
A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency
Authors: Bedoyan Jirair K. , Hecht Leah , Zhang Shulin , Tarrant Stacey , Bergin Ann , Demirbas Didem , Yang Edward , Shin Ha Kyung , Grahame George J. , DeBrosse Suzanne D. , Hoppel Charles L. , Kerr Douglas S. , Berry Gerard T. 
Published: June 2019

AbstractCongenital lactic acidosis due to pyruvate dehydrogenase phosphatase (PDP) deficiency is very rare. PDP regulates pyruvate dehydrogenase complex (PDC) and defective PDP leads to PDC deficiency. We report a case with functional PDC deficiency with low activated (+dichloroacetate) and inactivated (+fluoride) PDC activities in lymphocytes and fibroblasts, normal activity of other mitochondrial enzymes in fibroblasts, and novel biallelic frameshift mutation in the PDP1 gene, c.575dupT (p.L192FfsX5), with absent PDP1 product in fibroblasts. Unexpectedly, the patient also had low branched‐chain 2‐ketoacid dehydrogenase (BCKDH) activity in fibroblasts with slight elevation of branched‐chain amino acids in plasma and ketoacids in urine but with no pathogenic mutations in the enzymes of BCKDH, which could suggest shared regulatory function of PDC and BCKDH in fibroblasts, potentially in other tissues or cell types as well, but this remains to be determined. The clinical presentation of this patient overlaps that of other patients with primary‐specific PDC deficiency, with neonatal/infantile and childhood lactic acidosis, normal lactate to pyruvate ratio, elevated plasma alanine, delayed psychomotor development, epileptic encephalopathy, feeding difficulties, and hypotonia. This patient exhibited marked improvement of overall development following initiation of ketogenic diet at 31 months of age. To the best of our knowledge, this is the fourth case of functional PDC deficiency with a defined mutation in PDP1.SynopsisPyruvate dehydrogenase phosphatase (PDP) regulates pyruvate dehydrogenase complex (PDC) and defective PDP due to PDP1 mutations leads to PDC deficiency and congenital lactic acidosis.
Status of international normalized ratio control and treatment patterns in patients with nonvalvular atrial fibrillation taking vitamin K antagonist with or without antiplatelet therapy: Results from KORAFII registry
Authors: Park Hee‐Soon , Kim Young‐Hoon , Kim June Soo , Oh Yong‐Seog , Shin Dong‐Gu , Pak Hui‐Nam , Hwang Gyo‐Seung , Choi Kee‐Joon , Oh Seil , Kim Jin‐Bae , Lee Man‐Young , Park Hyung‐Wook , Kim Dae‐Kyeong , Jin Eun‐Sun , Park Jae‐Seok , Oh Il‐Young , Shin Dae‐Hee , Park Hyoung‐Seob , Kim Jun Hyung , Kim Nam‐Ho , Ahn Min‐Soo , Seo Bo‐Jeong , Kim Young‐Joo , Kang Seongsik , Lee Juneyoung 
Published: June 2019

AbstractBackgroundStudies have shown that the concomitant use of a vitamin K antagonist (VKA) and an antiplatelet (APL) drug increased the bleeding risk and was less effective at preventing ischemic events. This study aimed to investigate the control status of international normalized ratio (INR) and the discontinuation rate of a VKA in patients taking VKA plus an APL drug compared with those taking a VKA alone.MethodsData were extracted from the KORean Atrial Fibrillation Investigation II registry, a multicenter noninterventional prospective observational study. Nonvalvular atrial fibrillation (NVAF) patients with CHADS2 scores ≥ 1 who newly started (within 3 months) a VKA were enrolled and followed up for 1 year.ResultsA total of 866 NVAF patients (mean age, 67.7 years; 60.3% men) without a bleeding history were divided into the VKA+APL (n = 229) and VKA alone (n = 637) groups. During follow‐up, mean INR level was lower in the VKA+APL group than in the VKA alone group (1.7 ± 0.8 vs 1.9 ± 0.9, P = 0.0005). INR levels were poorly controlled in both groups (66.1% and 64.7%, respectively). Patients in the VKA+APL group more frequently discontinued VKA than patients in the VKA alone group (28.8% vs 24.2%, P = 0.045). Major causes of VKA discontinuation were uncontrolled INR level and patient dissatisfaction or concerns.ConclusionsThe conditions of NVAF patients were inadequately controlled with VKA with or without an APL. These findings suggest that other antithrombotic treatment options are warranted in NVAF patients to achieve INR control.
Mexiletine infusion challenge test for neonatal long QT syndrome with 2:1 atrioventricular block
Authors: Okuwaki Hajime , Kato Yoshiaki , Lin Lisheng , Nozaki Yoshihiro , Takahashi‐Igari Miho , Horigome Hitoshi 
Published: June 2019

AbstractFor applying a genotype‐based treatment in neonatal long QT syndrome (LQTS), early detection of the genotype becomes an important issue. We report a case of a neonate with LQTS type 3 that presented with 2:1 atrioventricular block and underwent a mexiletine infusion challenge test, and achieved shortening of the QTc and 1:1 atrioventricular conduction. The mexiletine infusion challenge test was helpful to make an early detection of the genotype of the LQTS and predicted the drug efficacy in a neonatal patient.
Antibacterial Cotton Fabrics Coated by Biodegradable Cationic Silicone Softeners
Authors: Mao Taoyan , Wei Yuan , Zheng Cheng , Cheng Wenjing , Zhang Zhenqiang , Zhu Yiting , Wang Runhao , Zeng Zhaowen 
Published: June 2019

AbstractA series of ester‐containing cationic silicone softeners with different alkyl chain lengths were successfully synthesized to manufacture antibacterial cotton fabrics. The relationship between the molecular structure and the softener's mechanical and physical properties was investigated. This study demonstrated that the fabrics treated with SiQCnCl softeners bearing short alkyl chains (n = 9, 11, and 13) showed better instantaneous hydrophilicity, close to that of a pristine cotton fabric. However, the SiQC17Cl‐treated fabrics with long alkyl chains showed the best softness, exceeding that achieved with the conventional finishing agent D1821. And the whiteness index of the fabrics decreased with the use of longer fabric finishing times, with the SiQC15Cl‐treated fabrics exhibiting the highest whiteness index. Moreover, it was also found that SiQCnCl‐treated fabrics showed higher antibacterial activity against Staphylococcus aureus than Escherichia coli, with the SiQC13Cl‐treated fabrics exhibiting the best antibacterial activity. In addition, a model depicting the antibacterial action of the prepared fabrics was illustrated. Finally, it was discovered that the synthesized ester‐containing cationic silicone softener showed better primary biodegradability than D1821 and DC‐5700, exceeding 80% after a 120‐h degradation.
Physical, sensorial and bioactive characteristics of white chocolate with encapsulated green tea extract
Authors: Lončarević Ivana , Pajin Biljana , Tumbas Šaponjac Vesna , Petrović Jovana , Vulić Jelena , Fišteš Aleksandar , Jovanović Petar 
Published: June 2019

AbstractBACKGROUNDMany studies have described cocoa polyphenols as being bioactive compounds with a potential positive effect on human health. Although dark chocolate is a most powerful source of antioxidants, their content is lower in milk chocolate; conversely, in white chocolate the fat‐free cocoa solids are omitted. The aim of this study was to increase polyphenol content and antioxidant capacity of white chocolate by adding encapsulated green tea extract (GTE) in amounts of 60, 80 and 100 g kg−1.RESULTSGTE influenced the particle size parameters, increasing the volume weighted mean from 15.43 μm in white chocolate to 19.34 μm in chocolate with 100 g kg−1 GTE. At the same time, the viscosity of enriched chocolate also increased owing to the addition of new solid particles. The surface color of enriched chocolates changed in accordance with the amount of encapsulate, where all enriched chocolates had a slightly lighter color after 12 months of storage. Total polyphenol content (mg gallic acid equivalents (GAE) kg−1) increased from 0.41 in white chocolate to 2.73 in chocolate enriched with maximal GTE. This amount of GTE increased antioxidant capacity (mmol Trolox equivalents kg−1) from 1.22 in white chocolate to 16.12. After 12 months of storage, degradation of polyphenols was found to be a maximum of 37.27%, while antioxidant capacity decreased up to 44.14%.CONCLUSIONIn addition to the impact on chocolate viscosity, GTE added value through the polyphenol content and sensorial profile of the new product with an unusual green tea flavor and a shelf life of at least 12 months. © 2019 Society of Chemical Industry
Evaluation of corm origin and climatic conditions on saffron (Crocus sativus L.) yield and quality
Authors: Cardone Loriana , Castronuovo Donato , Perniola Michele , Cicco Nunzia , Candido Vincenzo 
Published: June 2019

AbstractBACKGROUNDCrocus sativus L. is an autumn‐flowering geophyte belonging to the Iridaceae family, known for the medicinal and coloring uses of the spice from its dried stigmas. It is cultivated in countries with different pedoclimatic conditions. This paper reports on a two‐year research project carried out in the Basilicata region of southern Italy on the question of how to obtain the highest performance from saffron. It considers corms from three different geographical origins – ‘Sardinia’, ‘Abruzzo’ and ‘Kozani’ at three different cultivation sites, namely Castelgrande (40° 46′ N, 15° 26′ E, 781 m a.s.l.), Genzano di Lucania (40° 50′ N, 16° 08′ E, 344 m a.s.l.), and Villa d'Agri (40° 22′ N, 15° 48′ E, 638 m a.s.l.).RESULTSThe highest yields were obtained in the second year by the combination of ‘Genzano di L. × Sardinia’ and ‘Castelgrande × Abruzzo’ with 28.1 and 23.9 kg ha−1 of dried stigma, respectively.Saffron quality was determined according to ISO 3632, which classifies the samples into three categories depending on the crocin, picrocrocin, and safranal content. Results highlighted that the highest values for coloring (242.1) and bitterness (97.7) were achieved in Genzano di L. during 2013. Moreover, the crocins were correlated positively with stigma yield and air mean temperature but negatively with safranal.CONCLUSIONThis study demonstrated, through principal component analysis (PCA), that the cultivation site with higher air temperature and without excessive rain during the flowering period generated the best stigma yield with high‐quality traits. © 2019 Society of Chemical Industry
Anti‐inflammatory activity of β‐caryophyllene combined with docosahexaenoic acid in a model of sepsis induced by Staphylococcus aureus in mice
Authors: Brito Laís Ferraz , Oliveira Hellen Braga Martins , das Neves Selis Nathan , e Souza Clarissa Leal Silva , Júnior Manoel Neres Santos , de Souza Erika Pereira , Silva Lucas Santana Coelho da , de Souza Nascimento Flávia , Amorim Aline Teixeira , Campos Guilherme Barreto , de Oliveira Márcio Vasconcelos , Yatsuda Regiane , Timenetsky Jorge , Marques Lucas Miranda 
Published: June 2019

BACKGROUNDSepsis is a set of serious organic manifestations caused by an infection, whose progression culminates in exacerbated inflammation and oxidative stress, poor prognosis, and high hospital costs. Antioxidants used against sepsis have been evaluated, including essential oils such as β‐caryophyllene (BCP), and polyunsaturated fatty acids, such as docosahexaenoic acid (DHA). The aim of this study was to evaluate the anti‐inflammatory activity of the association of these two compounds.RESULTSTreatment with BCP‐DHA, at a dose of 200 μL/animal, significantly inhibited the migration of neutrophils in a Cg‐induced peritonitis model. After Staphylococcus aureus infection, in the groups treated with BCP‐DHA there was a significant decrease in the total and differential count of leukocytes, increased expression of cytokines TNF‐α and IFN‐γ in treated groups, an increase of IL‐4 and IL‐5 in B/D and B/D + SA groups, and an augmentation of IL‐6 and IL‐12 groups in B/D + SA groups. Histological and bacterial analysis revealed lower neutrophil migration and lower bacterial load in the infected and treated groups.CONCLUSIONIn general, the BCP‐DHA association presented anti‐inflammatory activity against two different models of acute inflammation and infection, showing promising potential as a therapeutic adjuvant in sepsis. © 2019 Society of Chemical Industry
Comparative analysis of nutrient content and energy of eggs from different chicken genotypes
Authors: Antova Ginka A , Gerzilov Vasko T , Petkova Zhana Y , Boncheva Veselina N , Bozhichkova Ivelina N , St Penkov Dimo , Petrov Petar B 
Published: June 2019

AbstractBACKGROUNDEggs are important foods in the daily diet of humans and have great biological activity and a high digestibility. Egg yolk is a good source of biologically active substances such as fatty acids, phospholipids, sterols and tocopherols. The eggs of seven chicken genotypes were analyzed for their chemical composition, and a detailed study of the lipids in egg yolk was conducted.RESULTSEnergy composition of the egg yolk and egg albumen was 29.06–30.51 MJ kg−1 and 19.77–20.93 MJ kg−1 respectively. Regarding their chemical composition: water ranged from 471.7 to 515.4 g kg−1 and 878.3–885.9 g kg−1; fat content in dry matter ranged from 607 to 647 g kg−1 and 6.7–11.6 g kg−1; protein varied from 302 to 331.7 g kg−1 and 823.6–892.5 g kg−1; ash ranged from 33.7 to 37.7 g kg−1 and 63.8–74.0 g kg−1; and nitrogen‐free extracts ranged from 12.7 to 36.5 g kg−1 and 35.0–96.2 g kg−1. The sterols and phospholipids in the yolk lipids were 16–26 g kg−1 and 59–127 g kg−1. The main fatty acids in the lipids were oleic (39.1–47.3%) and palmitic (26.0–35.5%) acids. Cholesterol in the yolk lipids ranged from 15.9 to 25.9 g kg−1. Phosphatidylcholine (389–573 g kg−1), phosphatidylethanolamine (219–355 g kg−1) and phosphatidylinositol (112–284 g kg−1) were the main phospholipids. The content of saturated fatty acids in the phospholipids was significantly higher than that in triacylglycerols.CONCLUSIONSmall variations in the chemical composition of eggs from seven different genotypes were observed. Significant differences in the fatty acid compositions of the main classes of phospholipids and the triacylglycerol fraction were established. © 2019 Society of Chemical Industry
Induction of Osteogenic MC3T3‐E1 Cell Differentiation by Nacre and Flesh Lipids of Tunisian Pinctada radiata
Authors: Ben Ammar Rym , Piet Marie‐Hélène , Brion Alice , Telahigue Khaoula , Werheni Rim , Rousseau Marthe , El Cafsi Mhamed , Gillet Pierre 
Published: June 2019

AbstractThe flesh of the Pinctada radiata pearl oyster from coastal Tunisia is considered as a high source of n‐3 and n‐6 and its shell nacre layer is a promising osteogenic biomaterial. Fatty acid (FA) analysis showed that the major components found in total FA (TFA) were 14:0, 16:0, and 18:0 saturated FA (SFA); 16:1, 18:1, and 20:1 monoenoic FA; 20:4n‐6 (ARA), 22:5n‐3 (DPA). Characteristically high levels of 20:5n‐3 (EPA) and 22:6n‐3 (DHA) (6.53–89.75 mg/100 g TFA) polyunsaturated FA (PUFA) were found, respectively, in the TFA of nacre and flesh. Evaluated the effects in vitro of lipids extracted from nacre (Ln) and from flesh (Lc) of P. radiata on growth and the differentiation of osteoblasts. Cytotoxicity tests (3‐(4, 5‐dimethylthiazolyl‐2)‐2, 5‐diphenyltetrazolium bromide [MTT] and lactic acid dehydrogenase c [LDH]) demonstrated that both extracts are nontoxic. Alizarin Red staining was used in an osteoblast differentiation model using the osteoblast MC3T3‐E1 cell line. It showed that the FA of both extracts induced osteoblast differentiation leading to mineralization. Reverse transcription‐polymerase chain reaction (RT‐PCR) showed a significantly higher expression of osteocalcin (Bglap) and runt‐related transcription (Runx2) in MC3T3‐E1 cells in the presence of Ln. No difference of osteopontin (Spp1) and Collagen type I (Col1a1) genes compared to the control was observed. In conclusion, these results supported, obtained from our in vitro experimental model used, the interest/potential of lipids extracted from nacre and P. radiata flesh to stimulate bone formation.
Effect of setting time and artificial saliva on the strength evaluated by different methods of dental silver amalgam: A comparative study
Authors: Mohammadi Z. , Mesgar A.S. , Rahmdar S. , Farhangi E. 
Published: June 2019

AbstractThe aim of this study is to evaluate the effect of setting time and artificial saliva on the strength of dental amalgam by diametral compressive strength, Hertzian failure loading testing and compressive strength test methods. Nine dental amalgam products are evaluated using three strength measurements, compressive, diametral, and Hertzian loading testing at early (1 h or 2 h), 24 h and 30 days after setting at 37 °C. The trituted amalgams are used to prepare Hertzian, tapered disc by manual condensation according to the ISO standard procedure (ISO 17988: 2014). The compressive and diametral testing specimens are obtained using the mechanical condensation by two apparatus with different specimen dimensions of height and diameter, 8.0 mm×4.0 mm and 2.0 mm×8.0 mm, respectively. The apparatus and schedule specification for preparing compressive testing specimens are according to ISO 24234: 2015 while dimensions of some parts of diametral testing apparatus were modified and the schedule was optimized to provide sound disc test‐pieces by a one‐shot procedure. The diametral and Hertzian testing specimens are also evaluated after 30 days under dry storage conditions and after aging in the artificial saliva. The artificial saliva was prepared according to ISO17988: 2014 standard specifications. The single diametral or “triple‐cleft” fracture path, and radial cracking are observed in all products for diametral and Hertzian testing methods, respectively. The discriminatory power in early strength tests is in order to Hertzian < diametral < compressive. A significant correlation between diametral and compressive strength value is observed at early setting time. It is found a correlation between diametral and Hertzian strength mean value and variance ratio in immersion test.
The effect of retrogression and re‐aging treatment on mechanical and tribological features of AA7075 aluminium alloy
Authors: Özer G. , Gecu R. , Karaaslan A. 
Published: June 2019

AbstractIn this study, T651‐applied AA7075 alloy was subjected to retrogression and re‐aging (RRA) process. Various retrogression temperatures (180 °C, 280 °C, 370 °C) and times (15 min, 30 min, 90 min) were used to determine the effects of temperature and time on the mechanical and tribological properties of the AA7075 alloy. All re‐aging stages were performed at 120 °C for 24 hours. Retrogression and re‐aging‐applied specimens were characterized by scanning electron microscope, transmission electron microscope, x‐ray diffraction, Charpy V‐notch impact and tensile tests. Brinell hardness measurements and ball‐on‐disc type tribometer measurements by using AISI 316 ball as a counterpart have also been conducted. Grain boundary precipitates in the T651‐applied specimen was transformed from continuous to the discontinuous structure after retrogression and re‐aging process. Continuous MgZn2 precipitates at grain boundaries were disintegrated and re‐precipitated along the grain boundaries. The sizes of intragranular precipitates have become coarsened by comparison with the T651 condition. Hardness, tensile strength and wear resistance were decreased whereas impact toughness values were increased with increasing retrogression temperature and time. The best wear resistance was obtained in the sample treated at 180 °C for 15 minutes.
Significant association between RETN genetic polymorphisms and alcohol‐induced osteonecrosis of femoral head
Authors: Liu Chang , An Feimeng , Cao Yuju , Wang Jiaqi , Tian Ye , Wu Huiqiang , Wang Jianzhong 
Published: June 2019

AbstractBackgroundAlcohol‐induced osteonecrosis of femoral head (ONFH) is a complex disease and genetic factors are one of the causes. The purpose of this study is to investigate the effects of RETN (resistin; OMIM: 605565) and LDLR (low density lipoprotein receptor; OMIM: 606945) polymorphisms on the risk of alcohol‐induced ONFH in Chinese Han population.MethodsA case–control study including 201 patients and 201 controls was designed. Seven single nucleotide polymorphisms (SNPs) in RETN gene and four SNPs in LDLR gene were genotyped using Agena MassARRAY platform. In allele model and genetic model, chi‐square test and logistic regression were used to study the associations between these SNPs and ONFH susceptibility. In addition, the relationships between these SNPs, clinical phenotypes, and blood lipid level with one‐way analysis of variance were analyzed.ResultsIn the allele model, rs7408174 and rs3745369 in RETN were associated with increased risk of alcohol‐induced ONFH, whereas rs34861192 and rs3219175 in RETN showed reduced risk of alcohol‐induced ONFH. In the genetic model, rs7408174 was associated with increased risk of alcohol‐induced ONFH in dominant model and log‐additive model. Rs3745369 showed an increased risk in codominant model, recessive model, and log‐additive model. Rs34861192 showed a decreased risk in codominant model, dominant model, and log‐additive model, and rs3219175 showed a decreased risk in dominant model and log‐additive model. The rs3745368 in RETN was associated with the clinical stage of the disease.ConclusionThese results suggest that RETN genetic polymorphisms are associated with the susceptibility of alcohol‐induced ONFH in Chinese Han population.