bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sampling the Folding Transition State Ensemble in a Tube-like Model of Protein
Authors: Hung Nguyen Ba , Hoang Trinh Xuan 
Published: May 2019

We used the tube model with Go-like potential for native contacts to study the folding transition of a designed three-helix bundle and a designed protein G-like structure. It is shown that both proteins in this model are two-state folders with a cooperative folding transition coincided with the collapse transition. We defined the transition states as protein conformations in a small region around the saddle point on a free energy surface with the energy and the conformationalroot mean square deviation (rmsd) from the native state as the coordinates. The transition state region on the free energy surface then was sampled by using umbrella sampling technique. We show that the transition state ensemble is broad consisting of different conformations that have different folded and unfolded elements.
EFFECT OF SOCIAL ENVIRONMENT AND PERSONALITY TRAITS ON ENTREPRENEURSHIP TENDENCIES OF STUDENTS: AN APPLICATION IN FOUNDATION UNIVERSITY
Authors: SELÇUK Hamide , BURAK Emel 
Published: May 2019

The aim of this study, which is an exploratory research, is to determine the effects of social environment and personality traits of university students on entrepreneurship tendencies. The universe of the research is comprised of all university students. The sample of the study consists of students enrolled at a foundation university. A questionnaire including the questions about the social environment and personality traits of university students and their entrepreneurship tendencies are applied. The data, collected by 130 questionnaires with complete and sufficient content, were analyzed and interpreted. As a result of the analysis, it has been seen that there is a positive relationship between risk taking propensity, the need for achievement, innovativeness and the entrepreneurship tendency.
Anti-PD-1 Immunotherapy-Induced Flare of a Known Underlying Relapsing Vasculitis Mimicking Recurrent Cancer
Authors: Nabel Christopher S. , Severgnini Mariano , Hung Yin P. , Cunningham-Bussel Amy , Gjini Evisa , Kleinsteuber Katja , Seymour Lake J. , Holland Martha K. , Cunningham Rachel , Felt Kristin D. , Vivero Marina , Rodig Scott J. , Massarotti Elena M. , Rahma Osama E. , Harshman Lauren C. 
Published: May 2019

Abstract

Safe use of immune checkpoint blockade in patients with cancer and autoimmune disorders requires a better understanding of the pathophysiology of immunologic activation. We describe the immune correlates of reactivation of granulomatosis with polyangiitis (GPA)—an antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis—in a patient with metastatic urothelial carcinoma treated with pembrolizumab. After PD-1 blockade, an inflammatory pulmonary nodule demonstrated a granulomatous, CD4+ T-cell infiltrate, correlating with increased CD4+ and CD8+ naïve memory cells in the peripheral blood without changes in other immune checkpoint receptors. Placed within the context of the existing literature on GPA and disease control, our findings suggest a key role for PD-1 in GPA self-tolerance and that selective strategies for immunotherapy may be needed in patients with certain autoimmune disorders. We further summarize the current literature regarding reactivation of autoimmune disorders in patients undergoing immune checkpoint blockade, as well as potential immunosuppressive strategies to minimize the risks of further vasculitic reactivation upon rechallenge with anti-PD-1 blockade.

Key Points
Nonspecific imaging findings in patients with cancer and rheumatological disorders may require biopsy to distinguish underlying pathology. Patients with rheumatologic disorders have increased risk of reactivation with PD-(L)1 immune checkpoint blockade, requiring assessment of disease status before starting treatment. Further study is needed to evaluate the efficacy of treatment regimens in preventing and controlling disease reactivation.
Evaluation of Obesity and Metabolic Status in Polycystic Ovary Syndrome in Fertile and Infertile Groups
Authors: BAKIR Vuslat Lale , KARAHAN Gül 
Published: May 2019

OBJECTIVE: The aim of our study was to compare the BMI and metabolic values ​​of fertile and infertile groups in patients with polycystic ovary syndrome (PCOS) and to determine the effect of obesity and metabolic status on fertility and infertile groups and the fertility effect of obesity. MATERIAL AND METHODS: The clinical and metabolic data of 230 patients who presented to the gynecology outpatient clinic of our hospital between 2013 and 2018 and were diagnosed with PCOS according to the Rotterdam Diagnosis Criteria were evaluated. Body mass index (BMI), waist ratio, menstrual period, fertility status, fertility duration, parity status, presence and degree of hirsutism were evaluated. 75 g oral glucose tolerance test (OGTT) was performed following appropriate diet and fasting period. Fasting glucose and insulin levels and insulin resistance cases were determined. Total cholesterol, HDL and LDL cholesterol levels were determined. Patients with BMI; The patients were divided into two groups as fertile and infertile, evaluated for obesity and metabolic data, and data on the relationship with BMI were calculated statistically. These metabolic disorders were compared to BMI and fertility status. RESULTS: The mean age of the patients was 26.7 years. The mean BMI was 28.92 ± 5.95 kg / m2. Only 25% of the patients had normal weight and 73% were overweight. 4 (1.7%) cases in the weak group with BMI less than 18.5, 58 (25.2%) cases in normal weight group with BMI 19-24.9, 71 (30.9%) in overweight group with BMI 25-29.9 There were 86 cases (37.4%) in obese group with BMI 30-39.9 and 11 cases (4.8%) in morbidly obese group with BMI of 40 and above. u (21.5%) is fertile. The duration of infertility ranged from 12 to 196 months, with a mean of 33.92 ± 24.25 months and a median of 24 months. The waist circumference is between 62 and 135 cm and the average is 87.76 ± 13.48 cm. The waist / hip ratio ranged from 0.65 to 0.98 and the mean was 0.80 ± 0.06. The distribution of BMI was similar in the fertile and infertile groups. 99 (43.1%) of the patients had insulin resistance, 77 (33.5%) had impaired glucose tolerance and 12 (5.2%) had DM. Mean blood lipid levels were not significantly different between fertile and infertile groups. The distribution of glucose metabolism disorders was similar in both groups. CONCLUSION: Obesity and metabolic disorders are more common in PCOS cases. There was no significant difference between fertile and infertile groups according to BMI.
Mednarodno sodelovanje v davčnih zadevah v Evropski uniji
Authors: Heinzer Aleksandra 
Published: May 2019

V prispevku obravnavamo pomen mednarodnega sodelovanja v davčnih zadevah kot eno izmed pomembnih novosti, ki jo vzporedno s polnopravnim članstvom Slovenije v EU prinaša Zakon o davčne postopku. Ključni faktor na tem področju je vloga evropskega prava, zato poudarjamo njegov vpliv na slovensko upravo. Pojasnjujemo, kakšna je dejanska vloga upravne pomoči med članicami, opredeljujemo njen pojem in datiramo razvoj pravne podlage za njeno izvajanje.Nadalje podrobno analiziramo celotno poglavje Zakona o davčnem postopku, ki zajema to tematiko, pri čemer se osredotočimo predvsem na odnos med pristojnimi organi držav članic. V zvezi z uveljavitvijo zakona izpostavljamo neskladje z Ustavo Republike Slovenije in opozarjamo na kolizijo, ki prihaja med njim in direktivo, ki jo zakon inkorporira. Končno ugotavljamo, da tovrstno povezovanje med državami glede izmenjave izkušenj prinaša pozitivne posledice tudi za Slovenijo.
Financial aspects of Public-Private Partnership
Authors: Sajko Livijo 
Published: May 2019

The growth of public requests is evident in the case of Croatia, but also present in every European country, with the government’s lack of ability to secure sufficient financial income. The look for additional sources of financing, in order to build public infrastructure, is directed therefore more and more to the private financing capital and to public-private partnerships. Together with such trends, one of the main questions that arise is, whether the employment of private capital in PPP-projects is valid from the economy point of view? If the overall project costs in the PPP-model are lower than the one in the traditional public sector model, calculated with the method of a Public Sector Comparator, the decision can be made to employ private capital in PPP-projects, which is valid from the economy point of view.
Spreminjanje upravljanja javnega potniškega prometa v Sloveniji na podlagi avstrijskih izkušenj
Authors: Blaž Janez , Hočevar Marko 
Published: May 2019

Direkcija RS za ceste je kot organ v sestavi Ministrstva za promet upravljalec javnega potniškega medkrajevnega cestnega prometa v Sloveniji. Kot koncedent ima z različnimi avtobusnimi prevozniki – koncesionarji sklenjenih 47 koncesijskih pogodb. V prispevku je najprej prikazano trenutno stanje na tem področju oziroma obstoječe relacije med koncedentom in koncesionarji in sicer z vidika usklajevanj, dodajanj in ukinjanj voznih redov, zagotavljanja finančnih sredstev kot tudi drugih zadev, ki so sestavni del koncesijskih pogodb. Izdelane so bile prikazane primerjalne analize z Avstrijo na področju ureditve integriranega, to je mestnega in medkrajevnega cestnega in železniškega javnega potniškega prometa (JPP) in sicer predvsem z vidika učinkovitosti JPP, prikazanega kot število prepeljanih potnikov glede na razpoložljiva finančna sredstva. Predstavljen je 3-nivojski model organizacije integriranega JPP v Avstriji in sistemska razdelitev odgovornosti in pooblastil na teh nivojih. V nadaljevanju so prikazane aktivnosti na Ministrstvu za promet oziroma Direkciji RS za ceste glede prihodnje ureditve področja javnega potniškega prometa in sicer po l. 2009, ko se iztečejo obstoječe koncesijske pogodbe na tem področju.
Razlaga pravnih pravil s pomočjo propozicijske logike - primer družinskih prejemkov
Authors: Rakar Iztok , Cukjati Domen 
Published: May 2019

Pogost vir dvoumnosti ter nejasnosti v pravnih besedilih je navajanje pogojev, ki določajo, ali nekomu določena pravica pripada ali ne. Problematični so primeri, ko je navedenih več obligatornih in opcijskih pogojev, po možnosti deloma zapisanih v trdilni in deloma v nikalni obliki. Namen tega prispevka je na primeru 47. člena »Pravilnika o postopkih za uveljavljanje pravic do družinskih prejemkov« (Ur.l. RS, št. 31/2008) pokazati, da lahko za sistematično dokazovanje vsebinske (ne)smiselnosti določene strukture pogojev uporabimo propozicijsko logiko. V prispevku najprej zapišemo besedilo 47. člena s sintakso propozicijske logike, poiščemo vse možne interpretacije besedila, med njimi izberemo vse, ki predstavljajo logično pravilne, vendar logično različne izjave, ter za vsako od njih preverimo ali predstavlja semantično smiselno formulacijo. Na ta način dokažemo, da je sedanja formulacija besedila zapisana dvoumno ter vsebinsko nesmiselno. Na koncu prispevka podamo splošno priporočilo za navajanje pogojev, predlagamo nedvoumno obliko zapisa besedila ter pokažemo, kakšne so v praksi posledice zaradi napačne formulacije pogojev.
GLASS3: A Standalone Multiscale Seismic Detection Associator
Authors: Yeck William L. , Patton John M. , Johnson Caryl E. , Kragness David , Benz Harley M. , Earle Paul S. , Guy Michelle R. , Ambruz Nicholas B. 
Published: May 2019

Abstract
The automated global real‐time association of phase picks into seismic sources comes with unique challenges when simultaneously monitoring at local, regional, and global scales. High spatial variability in seismic station density, transitory seismic data availability, and time‐varying noise characteristics of individual stations must be considered in the design of an associator that is fast and accurate with a low false association rate. These challenges are particularly apparent at the U.S. Geological Survey National Earthquake Information Center (NEIC), which monitors seismicity in near‐real time on local, regional, and global scales using seismic data from roughly 2100 real‐time seismic stations. To fully leverage this large dataset, NEIC developed a standalone self‐configuring seismic phase associator, GLobal ASSociator 3 (GLASS3) that simultaneously processes variably scaled 3D association webs, each with a unique set of nucleation criteria (e.g., nucleation stack threshold). GLASS3 has many useful features for real‐time monitoring including its computational efficiency, instantaneous pick processing, and on‐the‐fly configurability such as the creation and removal of targeted association webs and updates to supporting station metadata. GLASS3 runs both as part of a real‐time event processing system and as a configurable standalone associator that can be applied to a large variety of seismic problems. Here, we describe the GLASS3 algorithm and demonstrate (including input data and configuration files) its use in associating phase‐ambiguous picks on multiple scales.
Invasive tumor front in oral squamous cell carcinoma: an independent prognostic factor
Authors: Jeelani Tazeen , Amin Jibran , Rasheed Rabiya , Bilal Sheikh 
Published: May 2019

<p class="abstract"><strong>Background:</strong> Head and neck squamous cell carcinoma (HNSCC) is one of the most aggressive and invasive cancer types. Squamous cell carcinomas of the oral cavity are among the ten most common cancers in the world, and accounts for almost 3-5% of all malignancies. The invasive edges of head and neck squamous cell carcinomas often display different morphological and molecular characteristics than more superficial parts of the same tumor.</p><p class="abstract"><strong>Methods:</strong> In our 2 year retrospective study, carried at a tertiary care centre of north India, main aim was to evaluate the prognostic significance of several parameters of the modified Bryne’s grading system along with probability of survival in OSCC patients. </p><p class="abstract"><strong>Results:</strong> Out of 60 cases 40 were males and 20 were females. Tumor differentiation was assessed which showed that 90% of the tumors were well differentiated, 6.6% of the tumors were moderately differentiated and 3.4% of the tumors were poorly differentiated. The predominant POI in the primary OSCC was pattern 2 (63.4% in 38 cases) followed by pattern 3, pattern 1and pattern 4 (28.4% in17 cases, 6.6% in 4 cases and 1.6% in 1 case) respectively.</p><p class="abstract"><strong>Conclusions:</strong> Distributing all the cases according to the Bryne’s prognostic groups we found that 13 (21.7%) cases belonged to group with a score of &lt;9, and 47 cases (78.3%) had a score of &gt;9.<strong> </strong>The 5-year tumour-specific<strong> </strong>survival in OSCC patients with invasive front score of &lt;9 was 95% compared to 46.25% in patients with high invasive front score &gt;9.</p>
LİMAN SAHASINDA MEYDANA GELEN GEMİ KAZALARININ KONUMSAL ANALİZİ: EGE BÖLGESİ İÇİN BİR UYGULAMA
Authors: BÜBER Müge , TÖZ Ali Cemal 
Published: May 2019

Bu çalışmanın amacı, Ege Denizi’nin Türk karasuları
içerisinde meydana gelen gemi kazalarının coğrafi bilgi sistemleri kullanarak
konumsal analizini yapmak ve bölgenin gemi kazaları açısından risk düzeyini
tespit etmektir. Bu kapsamda, 2005-2017(Temmuz) yılları arasında meydana gelen toplam
106 gemi kazasına ait detaylar, Türk Ana Arama ve Kurtarma Koordinasyon Merkezi
(TMSRCC)’nin kaza veri tabanından elde edilmiştir. Gemi kazalarının konumsal
analizi, Coğrafi Bilgi Sistemleri(CBS) tabanlı Mapinfo 8.0 yazılımı ile
gerçekleştirilmiş olup, kaza frekanslarına göre bölgenin risk düzeyi tespit
edilmiştir. Çalışmada, kuru yük gemileri (28; %26) ve özel yat (25; %23) sınıfı
teknelerin sıklıkla gemi kazası yaşadıkları, ayrıca kazaya karışan gemilerin
büyük bir kısmının (64; %60) Türk bayraklı olduğu sonucuna ulaşılmıştır. Bölgede
en sık yaşanan kazaların ise karaya oturma (27; % 23) kazaları olduğu tespit
edilmiştir. Çalışmada İzmir liman iç sahası ve Yenikale mevkiinin gemi kazaları
açısından çok yüksek riskli (VHR) bölgeler olduğu sonucuna ulaşılmıştır. Bu
sonuçlar ışığında bölgedeki risk düzeyini azaltmak açısından alınması gerekli
tedbirler önerilmiştir.
Humanismo, un esfuerzo en la vida de Carlos Gutiérrez-Noriega
Authors: Ayala Pío Salomón , Huarcaya  Victoria Jeff 
Published: May 2019

El presente estudio es una aproximación histórica de la vocación humanista del investigador Carlos Gutiérrez-Noriega, considerando su trayectoria sobresaliente en la investigación científica original y el cultivo de las humanidades. Destacó en diversos escenarios del saber; las ciencias básicas en los laboratorios de farmacología, el estudio de las características y problemas propios del hombre andino y el cocaísmo en sus aspectos biológicos, psicológicos, culturales, antropológicos y sociológicos. Se invita a nuestras pasadas y nuevas generaciones a reflexionar sobre la trascendente experiencia del profesor Gutiérrez-Noriega durante su vida y tiempo.
THE EFFECTIVENESS OF EDUCATIONAL GAMES IN MATH LEARNING IN ELEMENTARY SCHOOL
Authors: Herzamzam Dyah Anungrat 
Published: May 2019

<p><em>The purpose of this research is to know the effectiveness of: (1) android-based educational games and (2) without the games in learning mathematics.This type of research is experimental with Pretest-Posttest design Randomized Control Group Design. In the process of experimentation conducted observations on two groups of learning i.e. experimental group one which was given treatment with android-based educational games in math, learning and a control group with no game. The population of the research was all learners class II SD PB Sudirman Jakarta with samples of learners classes IIA, IIB, and IIC. Research instrument was a matter of addition and subtraction tests that have been tested with Alpha 0.826. Data analysis techniques using Anava followed by Scheffe test. </em><em>The results showed that: (1) there is a significant difference in effectiveness between learning mathematics using android-based educational games and without a game in learning addition and subtraction class II SD PB Sudirman Jakarta Timur ( FH = 6.211 &gt; Ft (0.05) = 3.02); (2) there is a significant difference in the effectiveness of media math learning using android-based educational games and learning in games without fractions, (sig (p) = 0.005 &lt; 0.05); This shows that the educational learning games mathematics better and effective than without games.</em></p>
Blood Pressure and Early Mobilization After Total Hip and Knee Replacements
Authors: Smits Michael , Lin Sandra , Rahme Jessica , Bailey Michael , Bellomo Rinaldo , Hardidge Andrew 
Published: May 2019

Background:
Early mobilization is an important therapeutic goal after total knee replacement and total hip replacement. Orthostatic hypotension and orthostatic intolerance can impede mobilization. Midodrine hydrochloride, an orally administered vasoconstrictor, may improve blood pressure and diminish the prevalence of adverse mobilization events.

Methods:
We conducted a pilot change-of-practice study. Two cohorts, each comprising 10 patients managed with total knee replacement and 10 patients managed with total hip replacement, were managed with blood pressure-adjusted midodrine, which was administered 3 times daily for the first 72 hours postoperatively at either a low dose (2.5 or 5 mg) or a higher dose (5 or 10 mg). These patients were then matched with an equivalent preintervention cohort of patients.

Results:
The midodrine protocol was instituted effectively and with high compliance. Hypotension was uncommon across all groups, with the mean lowest systolic blood pressure ranging from 110 to 121 mm Hg. Moreover, adverse mobilization events were uncommon across all groups (prevalence, 9.6% in the control group, 5.6% in the low-dose group, and 2.9% in the high-dose group) (p = 0.046 for the high-dose group versus the control group). A midodrine dose of 10 mg generated a significant mean dose-related systolic blood pressure increase of 14 mm Hg at 2 hours after administration (p < 0.001). There were no significant differences between the groups in terms of mean systolic blood pressure, biochemical markers, or intravenous therapy administration.

Conclusions:
A dose of 10 mg was found to achieve a significant systolic blood pressure response at 2 hours after administration and, in patients who received higher-dose midodrine, adverse mobilization events appeared less common. Additional investigation with a blinded randomized controlled trial, utilizing 10 mg of midodrine 2 hours before mobilization, would be needed to confirm the efficacy of midodrine therapy.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
The Carbon Effects of the Urban Ecological Recreational System Based on Systems Simulation
Authors: Li Hua , Tong Helong , Wang Xiaoxiang 
Published: May 2019

Abstract
As a major component of urban ecological systems, the urban ecological space is an important carbon pool in the urban carbon circulation. Meanwhile, its special recreational function adds to the complexity of its carbon effects. According to the carbon process and effects of the urban ecological recreational system, the Source-Leakage-Sink-Order (SLSO) framework is proposed as the basis of the four subsystems of the system model. Consisting of 63 parameters, the system dynamics model of urban ecological recreational system is constructed by using VENSIM PLE. Then the urban ecological recreational system in Shanghai under different scenarios is simulated, and the carbon sources and sinks of the system as well as the process of carbon effects such as carbon footprints are analyzed and predicted. Research shows that due to the imbalance of the spatial pattern of ecological recreational space, the carbon sink effects of the system are quite limited. The human carbon source is the main contributor of the system’s carbon sources and the carbon footprint deficit is striking. The management ability of ecological recreational space influences the carbon sink potentials of the system. In addition, the maintenance mode of ecological green space plays a non-trivial role in the composition of carbon sources.
The Influence of Third-party E-Commerce Platform Price Limits on the Dual-Channel Strategy of Manufacturers
Authors: Wang Cong , Yang Huifang , Yang Deli 
Published: May 2019

Abstract
Powerful platform operators always set price limits for sellers on the platform. This paper establishes Stackelberg game models according to two pricing models when the manufacturer enters the third-party e-commerce platform and sells products online. The first is a seller-pricing model in which the manufacturer decides the online price. The second is a platform-pricing model in which the platform decides the online price. We obtain the equilibrium results for these two models and the condition that allows the manufacturer to adopt the dual-channel strategy by comparing the operation decisions and performance of supply-chain members in the two models. Results show that the dual-channel strategy of the manufacturer always decreases the profit of the traditional retailer. In comparison with the seller-pricing model, the platform-pricing model always erodes parts of the manufacturers profit obtained by the dual-channel strategy. The manufacturer will pass on the partial loss to the retailer using relative leadership in the platform-pricing model, which renders the profit of the retailer lower than that in the seller-pricing model. Also, price limits do not always bring the platform more profits; sometimes the platform is forced to set a low price.