bluuebunny/crossref_metadata_2025_split huggingface dataset:
BRAF Mutations in Low-Grade Serous Ovarian Cancer and Response to BRAF Inhibition
Authors: Moujaber Tania , Etemadmoghadam Dariush , Kennedy Catherine J. , Chiew Yoke-Eng , Balleine Rosemary L. , Saunders Catherine , Wain Gerard V. , Gao Bo , Hogg Russell , Srirangan Sivatharsny , Kan Casina , Fereday Sian , Traficante Nadia ,   Australian Ovarian Cancer Study, Patch Ann-Marie , Pearson John V. , Waddell Nicola , Grimmond Sean M. , Dobrovic Alexander , Bowtell David D.L. , Harnett Paul R. , deFazio Anna 
Published: May 2018

Purpose Low-grade serous ovarian carcinoma (LGSC) responds poorly to chemotherapy and is characterized by activating mutations in the Ras sarcoma–mitogen-activated protein kinase (RAS-MAPK) pathway, including oncogenic BRAF. However, response to BRAF inhibitors is tumor-type specific. Significant improvement in survival is seen in patients with BRAF-mutant melanoma, but other cancer types, such as colorectal cancers, are generally less sensitive. We examined the frequency and characteristics of BRAF-mutated LGSC and described the response to treatment with BRAF inhibitors. Patients and Methods Mutations were assessed in LGSC (N = 65) by using targeted, exome, and whole-genome sequencing. Patient characteristics, treatment, and clinical outcome were assessed, and the median follow-up time was more than 5 years. BRAF inhibitors were trialed in two patients with a somatic BRAF V600E mutation: one patient received dabrafenib monotherapy and was monitored clinically, biochemically (cancer antigen [CA]-125 levels), and with positron emission tomography (PET) imaging. Expression of the BRAF V600E protein in this patient was assessed by immunohistochemistry. Results Among patients with LGSC, nine (13.8%) of 65 had a somatic BRAF mutation. Of the nine patients with BRAF mutation–positive LGSC, four experienced progressive disease that did not respond to conventional chemotherapy. Two of the patients experienced progression quickly and died as a result of disease progression, and two received targeted treatment. Two patients with BRAF V600E mutation received BRAF inhibitors at relapse and both achieved durable responses. Conclusion BRAF mutations are not uncommon in patients with LGSC and should be routinely tested, because BRAF inhibitors can be an effective treatment for these patients. The results highlight the need for targeted treatment in this rare tumor type, and a prospective study is needed to formally assess the response rate and clinical benefit.
Rebounding with Medicare: Reform and Counterreform in American Health Policy
Authors: Starr Paul 
Published: May 2018

Abstract
America's major health care programs were all enacted on the rebound from defeat of more expansive progressive ideas. Chastened reformers have typically adopted rebound strategies that accommodate some sources of opposition, incorporate elements of counterreforms, and reflect intervening institutional change. This dynamic has unfolded three times: from the Progressive Era to the enactment of Medicare and Medicaid in 1965, from the late 1960s to the expansion of Medicaid in the 1980s, and from defeat of the 1993 Clinton plan to the enactment of the Children's Health Insurance Plan in 1997 and the Affordable Care Act in 2010. Setbacks in the Trump era will require advocates of universal coverage to coalesce around a rebound strategy that similarly takes account of recent developments and recognizes the Affordable Care Act's limitations and political vulnerabilities. This article argues that Medicare provides a platform for such a strategy and that the next fiscally and politically feasible step is the creation of a new “Midlife Medicare” program that would extend protection to people fifty to sixty-four years of age.
Morphological Development and Coordination Change in the Course of Cd2+ Hydrolysis
Authors: Sakai Yuka , Kawamoto Daisuke , Yokoyama Takushi , Miyazaki Akane 
Published: May 2018

Abstract
Morphological development from nanowire to hexagonal platelet was observed for hydrolysis products of Cd(NO3)2 aqueous solution. 113Cd cross-polarization magic-angle spinning nuclear magnetic resonance spectroscopy and X-ray diffraction revealed that the morphological development corresponds to the change of coordination environment around Cd2+ from double salts containing nitrate ions to β-Cd(OH)2.
CattleReview
Authors: Barrett David C 
Published: May 2018

Introduction: From 1st June 2018, Red Tractor Assurance dairy standards regarding medicine use are being strengthened. It will now be a full standard that highest priority critically important antimicrobials (HP-CIAs), defined as third-generation or fourth-generation cephalosporins and fluoroquinolones, only be used as a last resort following veterinary advice and supported by appropriate diagnostics including sensitivity testing. This edition of Cattle Review considers recent published research from both the University of Nottingham and University of Bristol pertinent to this change.
Quantifying Atherogenic Lipoproteins: Current and Future Challenges in the Era of Personalized Medicine and Very Low Concentrations of LDL Cholesterol. A Consensus Statement from EAS and EFLM
Authors: Langlois Michel R , Chapman M John , Cobbaert Christa , Mora Samia , Remaley Alan T , Ros Emilio , Watts Gerald F , Borén Jan , Baum Hannsjörg , Bruckert Eric , Catapano Alberico , Descamps Olivier S , von Eckardstein Arnold , Kamstrup Pia R , Kolovou Genovefa , Kronenberg Florian , Langsted Anne , Pulkki Kari , Rifai Nader , Sypniewska Grazyna , Wiklund Olov , Nordestgaard Børge G ,   for the European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Joint Consensus Initiative
Published: May 2018

Abstract

BACKGROUND
The European Atherosclerosis Society–European Federation of Clinical Chemistry and Laboratory Medicine Consensus Panel aims to provide recommendations to optimize atherogenic lipoprotein quantification for cardiovascular risk management.

CONTENT
We critically examined LDL cholesterol, non-HDL cholesterol, apolipoprotein B (apoB), and LDL particle number assays based on key criteria for medical application of biomarkers. (a) Analytical performance: Discordant LDL cholesterol quantification occurs when LDL cholesterol is measured or calculated with different assays, especially in patients with hypertriglyceridemia &gt;175 mg/dL (2 mmol/L) and low LDL cholesterol concentrations &lt;70 mg/dL (1.8 mmol/L). Increased lipoprotein(a) should be excluded in patients not achieving LDL cholesterol goals with treatment. Non-HDL cholesterol includes the atherogenic risk component of remnant cholesterol and can be calculated in a standard nonfasting lipid panel without additional expense. ApoB more accurately reflects LDL particle number. (b) Clinical performance: LDL cholesterol, non-HDL cholesterol, and apoB are comparable predictors of cardiovascular events in prospective population studies and clinical trials; however, discordance analysis of the markers improves risk prediction by adding remnant cholesterol (included in non-HDL cholesterol) and LDL particle number (with apoB) risk components to LDL cholesterol testing. (c) Clinical and cost-effectiveness: There is no consistent evidence yet that non-HDL cholesterol-, apoB-, or LDL particle-targeted treatment reduces the number of cardiovascular events and healthcare-related costs than treatment targeted to LDL cholesterol.

SUMMARY
Follow-up of pre- and on-treatment (measured or calculated) LDL cholesterol concentration in a patient should ideally be performed with the same documented test method. Non-HDL cholesterol (or apoB) should be the secondary treatment target in patients with mild to moderate hypertriglyceridemia, in whom LDL cholesterol measurement or calculation is less accurate and often less predictive of cardiovascular risk. Laboratories should report non-HDL cholesterol in all standard lipid panels.
Retranslating Strindberg: Adaptation, (re)location and site-related performance
Authors: Connor Rachel 
Published: May 2018

Abstract
This article offers a practitioner’s perspective on the experience of adapting, devising and co-producing A Dream Play for a northern British audience at an art café during the Manchester Festival Fringe in 2015. It explores how the process of re-versioning A Dream Play provides insights that might be of relevance to the fields of adaptation and translation studies. Starting from the position that translation is ‘rewriting’ – an ‘active form of interpretation whose cultural impact is extensive’ – the article argues that the adaptation of August Strindberg’s text to a devised, site-related performance amplified that ‘cultural impact’ through its ‘retranslation’ to a non-traditional theatre site. In shaping the responses of cast and audience to the physical performance space, the production created a ‘poetics of the collective’, which permitted a new engagement with Strindberg’s canonical text. The piece concludes with some reflections on the constraints of the writer-adaptor in the re-visioning, particularly in an iconic text such as A Dream Play.
Women’s International Alliances in an Emergent Ghana
Authors: Sackeyfio-Lenoch Naaborko 
Published: May 2018

Abstract
As Africans sought to build nations during the independence era, their efforts were informed by international currents. In addition to political parties, nonstate actors such as civil society groups played a role in this process. Women activists in an emergent Ghana—most notably, the National Federation of Gold Coast Women and one of its leaders, Evelyn Amarteifio—created a new form of internationalism that merged the nation-building strategies of Kwame Nkrumah and the Convention People’s Party with women’s efforts elsewhere in Africa and the wider Diaspora. Thus, she and her organization did not fit neatly into the conventional Ghanaian nationalist political and economic narrative and at times came into conflict with national political leaders. Examining Amarteifio’s actions and those of the Federation demonstrates the diverse and conscious ways in which African women sought to achieve their own objectives through engagements with the Ghanaian state and international groups.
Sex, Drugs, and Female Agency: Why Siramori Diabaté’s Song “Nanyuman” Was Such a Success in Mali and Guinea
Authors: Jansen Jan , Counsel Graeme , Camara Brahima 
Published: May 2018

Abstract
This article presents the lyrics of the song “Nanyuman” by Mali’s legendary female griot (bard) Siramori (Sira Mory) Diabaté (c. 1925–1989). It will demonstrate how a female griot integrates into her songs topical moral discussions on the position of married women in the socialist-inspired nations of Guinea and Mali in the 1960s and 1970s. Through the voice of “Nanyuman,” the protagonist of the song, Siramori, comments in ways a male griot never could, discussing marriage, sex, men’s roles as husbands, motherhood, and even the use of stimulant drugs. This source publication shows that the remarkable rise of female griots in West Africa from the 1960s onwards can be explained by new topical debates on West African society, and not only by technological innovations and new aesthetic appreciations of female voices that have received scholarly attention. The performance of “Nanyuman” also reveals Siramori’s artistic and comedic talents as an entertainer, thus evidencing why she was elevated to the highest ranks of musicians in Mali.
Alternating Modulation of Subthalamic Nucleus Beta Oscillations during Stepping
Authors: Fischer Petra , Chen Chiung Chu , Chang Ya-Ju , Yeh Chien-Hung , Pogosyan Alek , Herz Damian M. , Cheeran Binith , Green Alexander L. , Aziz Tipu Z. , Hyam Jonathan , Little Simon , Foltynie Thomas , Limousin Patricia , Zrinzo Ludvic , Hasegawa Harutomo , Samuel Michael , Ashkan Keyoumars , Brown Peter , Tan Huiling 
Published: May 2018

Gait disturbances in Parkinson's disease are commonly refractory to current treatment options and majorly impair patient's quality of life. Auditory cues facilitate gait and prevent motor blocks. We investigated how neural dynamics in the human subthalamic nucleus of Parkinsons's disease patients (14 male, 2 female) vary during stepping and whether rhythmic auditory cues enhance the observed modulation. Oscillations in the beta band were suppressed after ipsilateral heel strikes, when the contralateral foot had to be raised, and reappeared after contralateral heel strikes, when the contralateral foot rested on the floor. The timing of this 20–30 Hz beta modulation was clearly distinct between the left and right subthalamic nucleus, and was alternating within each stepping cycle. This modulation was similar, whether stepping movements were made while sitting, standing, or during gait, confirming the utility of the stepping in place paradigm. During stepping in place, beta modulation increased with auditory cues that assisted patients in timing their steps more regularly. Our results suggest a link between the degree of power modulation within high beta frequency bands and stepping performance. These findings raise the possibility that alternating deep brain stimulation patterns may be superior to constant stimulation for improving parkinsonian gait.SIGNIFICANCE STATEMENTGait disturbances in Parkinson's disease majorly reduce patients' quality of life and are often refractory to current treatment options. We investigated how neural activity in the subthalamic nucleus of patients who received deep brain stimulation surgery covaries with the stepping cycle. 20–30 Hz beta activity was modulated relative to each step, alternating between the left and right STN. The stepping performance of patients improved when auditory cues were provided, which went along with enhanced beta modulation. This raises the possibility that alternating stimulation patterns may also enhance beta modulation and may be more beneficial for gait control than continuous stimulation, which needs to be tested in future studies.
Depression in type 1 diabetes was associated with high levels of circulating galectin-3
Authors: Melin Eva Olga , Dereke Jonatan , Thunander Maria , Hillman Magnus 
Published: May 2018

Objective
Neuroinflammatory responses are implicated in depression. The aim was to explore whether depression in patients with type 1 diabetes (T1D) was associated with high circulating galectin-3, controlling for metabolic variables, s-creatinine, life style factors, medication and cardiovascular complications.

Design
Cross-sectional.

Methods
Participants were T1D patients (n = 283, 56% men, age 18–59 years, diabetes duration ≥1 year). Depression was assessed by Hospital Anxiety and Depression Scale-depression subscale. Blood samples, anthropometrics and blood pressure were collected, and supplemented with data from medical records and the Swedish National Diabetes Registry. Galectin-3 ≥2.562 µg/l, corresponding to the 85th percentile, was defined as high galectin-3.

Results
Median (quartile1, quartile3) galectin-3 (µg/l) was 1.3 (0.8, 2.9) for the 30 depressed patients, and 0.9 (0.5, 1.6) for the 253 non-depressed, P = 0.009. Depression was associated with high galectin-3 in all the 283 patients (adjusted odds ratio (AOR) 3.5), in the 161 men (AOR 3.4), and in the 122 women (AOR 3.9). HbA1c, s-lipids, s-creatinine, blood pressure, obesity, smoking, physical inactivity, cardiovascular complications and drugs (antihypertensive, lipid lowering, oral antidiabetic drugs and antidepressants) were not associated with high galectin-3.

Conclusions
This is the first study to show an association between depression and galectin-3. Depression was the only explored parameter associated with high circulating galectin-3 levels in 283 T1D patients. High galectin-3 levels might contribute to the increased risk for Alzheimer’s disease, cardiovascular and all-cause mortality observed in persons with depression. Potentially, in the future, treatment targeting galactin-3 might improve the prognosis for patients with high galectin-3 levels.
A Dense Linkage Map of Lake Victoria Cichlids Improved the Pundamilia Genome Assembly and Revealed a Major QTL for Sex-Determination
Authors: Feulner Philine G D , Schwarzer Julia , Haesler Marcel P , Meier Joana I , Seehausen Ole 
Published: May 2018

Abstract
Genetic linkage maps are essential for comparative genomics, high quality genome sequence assembly and fine scale quantitative trait locus (QTL) mapping. In the present study we identified and genotyped markers via restriction-site associated DNA (RAD) sequencing and constructed a genetic linkage map based on 1,597 SNP markers of an interspecific F2 cross of two closely related Lake Victoria cichlids (Pundamilia pundamilia and P. sp. ‘red head’). The SNP markers were distributed on 22 linkage groups and the total map size was 1,594 cM with an average marker distance of 1.01 cM. This high-resolution genetic linkage map was used to anchor the scaffolds of the Pundamilia genome and estimate recombination rates along the genome. Via QTL mapping we identified a major QTL for sex in a ∼1.9 Mb region on Pun-LG10, which is homologous to Oreochromis niloticus LG 23 (Ore-LG23) and includes a well-known vertebrate sex-determination gene (amh).
The Protein Arginine Methyltransferase PRMT-5 Regulates SER-2 Tyramine Receptor-Mediated Behaviors inCaenorhabditis elegans
Authors: Bowitch Alexander , Michaels Kerry L , Yu Michael C , Ferkey Denise M 
Published: May 2018

AbstractG protein-coupled receptors are 7-pass transmembrane receptors that couple to heterotrimeric G proteins to mediate cellular responses to a diverse array of stimuli. Understanding the mechanisms that regulate G protein-coupled receptors is crucial to manipulating their signaling for therapeutic benefit. One key regulatory mechanism that contributes to the functional diversity of many signaling proteins is post-translational modification. Whereas phosphorylation remains the best studied of such modifications, arginine methylation by protein arginine methyltransferases is emerging as a key regulator of protein function. We previously published the first functional evidence that arginine methylation of G protein-coupled receptors modulates their signaling. We report here a third receptor that is regulated by arginine methylation, the Caenorhabditis elegansSER-2 tyramine receptor. We show that arginines within a putative methylation motif in the third intracellular loop of SER-2 are methylated by PRMT5 in vitro. Our data also suggest that this modification enhances SER-2 signaling in vivo to modulate animal behavior. The identification of a third G protein-coupled receptor to be functionally regulated by arginine methylation suggests that this post-translational modification may be utilized to regulate signaling through a broad array of G protein-coupled receptors.
Presentación inusual de una fractura-luxación peritalar. [Unusual presentation of a peritalar fracture dislocation]
Authors: Del Vecchio Jorge Javier , Codesido Mariano , Uzair Anuar Emanuel , Ghioldi Mauricio Esteban , Yañez Arauz Juan Manuel 
Published: May 2018

Una luxación peritalar implica la disrupción simultánea de las articulaciones talocalcanea y talonavicular. Es relativamente poco frecuente y representa aproximadamente del 1% al 1,5% de todas las lesiones traumáticas del pie.Las luxaciones peritalares laterales son menos frecuentes (17%) y las posteriores (2,5%) y anteriores son raras (1%). Aproximadamente el 55% de los subtipos medial y el 72% de los subtipos laterales se asocian con fracturas. Una mujer de treinta y seis años sufrió un traumatismo indirecto (kite-surf) después de caerse del kite-board (tabla) cerca de la playa y tratando de evitar un accidente debido al viento intenso. Presentó una luxación peritalar lateral con fracturas de escafoides tarsiano, calcáneo y peroné asociadas. Después de la evaluación primaria, se intentó una reducción cerrada tres días después del trauma. Después de seis días de la lesión se realizó la cirugía. Las fracturas se trataron con osteosíntesis mínimamente invasiva y en el postoperatorio la paciente desarrolló un síndrome de dolor regional complejo. Se recomienda un diagnóstico precoz de las luxaciones peritales y un rápido reconocimiento de fracturas asociadas e infrecuentes y de esta forma evitar complicaciones evitables. AbstractA peritalar dislocation involves simultaneous disruption of the talocalcaneal and talonavicular joints. It is relatively uncommon and account for approximately 1% to 1.5% of all traumatic foot injuries. Medial dislocation is the most frequent type accounting for approximately 80% of reported cases. Lateral peritalar dislocations are less common (17%), and posterior (2.5%) and anterior dislocations are rare (1%). Approximately 55% of medial and 72% of lateral subtypes are associated with fractures. We report the case of a 36-year-old woman who suffered an indirect traumatism during kitesurf practice, after falling from the kite-board trying to avoid an accident. She presented a lateral peritalar dislocation with associated navicular, calcaneal and fibular fractures. A closed reduction was attempted three days from trauma. Six days after the lesion, surgery was performed. We recommend an early diagnosis of peritalar dislocations and a correct recognitionof infrequent fractures to avoid usual complications.
Funcionalidad y calidad de vida luego de la cirugía de escoliosis neuromuscular. [Functionality and quality of life after neuromuscular scoliosis surgery.]
Authors: Curbelo Nova Patricia Carolina , Silveri Claudio , Cuneo Alejandro , Olivera Rodrigo 
Published: May 2018

ObjetivoEl objetivo de nuestro trabajo es estudiar las complicaciones de la cirugía en las escoliosis neuromusculares operadas en nuestro centro, así como la funcionalidad y calidad de vida de los pacientes luego del tratamiento quirúrgico.MétodosSe realizó un estudio retrospectivo, tipo serie de casos. Se revisó la historia clínica y se entrevistó a paciente y cuidador principal. Se valoró los resultados luego de la cirugía en cuanto a las complicaciones, funcionabilidad, calidad de vida y grado de satisfacción de los cuidadores.ResultadosObtuvimos un 26,7% de complicaciones, debidas a infección y alteraciones hemodinámicas. En cuanto a la funcionabilidad y calidad de vida de estos pacientes obtuvimos resultados positivos, siendo más significativos en cuanto a la capacidad de estar sentado y las actividades de la vida diaria.ConclusionesLa cirugía de los pacientes con escoliosis neuromuscular mejora la capacidad y el equilibrio de estar sentado, favoreciendo con esto la capacidad digestiva, respiratoria y de vida social del paciente. Si bien se trata de cirugías con altos indices de complicaciones muestra indices elevados de satisfacción por parte de los cuidadores. AbstractIntroduction: The objective of this study was to evaluate surgical complications in patients with scoliosis operated on in our Center, as well as their functionality and quality of life after surgical treatment.Methods: A retrospective case series study was carried out. Medical history was reviewed and the patient and primary caregiver were interviewed. Results after surgery were assessed for complications, function, quality of life and caregivers´ degree of satisfaction.Results: Complication rate was 26.7%, due to infection and hemodynamic alterations. Positive results were obtained regarding function and quality of life of these patients, being more significant in terms of the ability to be seated and activities of daily living.Conclusions: Surgery of patients with neuromuscular scoliosis improves the capacity and balance of sitting, favoring digestive, respiratory and social life capacity. Although rate of complications is high, satisfaction rates on the part of the caregivers are elevated.