bluuebunny/crossref_metadata_2025_split huggingface dataset:
How key transitions influence school and labour market careers of descendants of Moroccan and Turkish migrants in the Netherlands
Authors: Crul Maurice 
Published: October 2018

AbstractMost educational research examines school outcomes at certain stages or at the final stage of the school career. This article looks at the entire school career and the transition to the labour market. It focuses on key transitions to identify the educational institutional arrangements that either help or hinder school and labour market success among the most disadvantaged groups in the Netherlands: young people of Moroccan and Turkish descent. The Dutch educational system is one of the most complicated school systems in Europe. Consequently, parents and children have to make many ‘choices’ when navigating it. Many of these key ‘choice’ moments are selection points, either because they are not real choices but dependent upon a teacher’s recommendation or because parents and pupils need a great deal of information about the school system in order to make a choice. This usually results in inequalities for the most disadvantaged groups. Because selection is disguised as ‘choices’, the structural inequalities of the Dutch school system are not usually perceived as blocking mechanisms for disadvantaged students
Burden of non‐motor symptoms in Parkinson's disease patients predicts improvement in quality of life during treatment with levodopa‐carbidopa intestinal gel
Authors: Ray Chaudhuri K. , Antonini A. , Robieson W. Z. , Sanchez‐Soliño O. , Bergmann L. , Poewe W. ,   the GLORIA study co‐investigators
Published: October 2018

Background and purposeGLORIA, a registry conducted with 375 advanced Parkinson's disease patients treated with levodopa‐carbidopa intestinal gel (LCIG) for 24 months in routine clinical care, demonstrated significant reductions from baseline in ‘off’ time and ‘on’ time with dyskinesia and improvements in the Non‐Motor Symptom Scale (NMSS) total and individual domain scores, and in Parkinson's Disease Questionnaire 8 item (PDQ‐8) total score.MethodsAssociations between baseline NMSS burden (NMSB), the multi‐domain NMSS total score and the PDQ‐8 total score were investigated for 233 patients. Baseline NMSB was assigned to five numerical categories defined by the NMSS total cutoff scores (0–20, 21–40, 41–60, 61–80 and >80). Pearson and Spearman correlations were calculated at month 24.ResultsThe response of LCIG was assessed using validated criteria after 24 months. The proportion of patients decreasing ≥ 30 NMSS score points was 47% in the most affected NMSB category (NMSS total score > 80). A positive association was noted between baseline NMSB and NMSS total score (0.57, P < 0.0001), as well as between NMSS total score and PDQ‐8 total score (0.46, P < 0.0001). Associations between improvements of the NMSS domain sleep/fatigue and PDQ‐8 total score (0.32, P = 0.0001) as well as between the NMSS domain mood/cognition and PDQ‐8 total score (0.37, P < 0.0001) were also shown.ConclusionsThis analysis demonstrated positive associations between NMSS baseline burden and improvements of non‐motor symptoms. Improvements of non‐motor symptoms were associated with improved quality of life in advanced parkinsonian patients during a 2‐year treatment with LCIG and reflect the long‐term non‐motor efficacy of this treatment.
Rapid detection of equine infectious anaemia virus nucleic acid by insulated isothermal RT‐PCR assay to aid diagnosis under field conditions
Authors: Cook R. F. , Barrandeguy M. , Lee P.‐Y. A. , Tsai C.‐F. , Shen Y.‐H. , Tsai Y.‐L. , Chang H.‐F. G. , Wang H.‐T. T. , Balasuriya U. B. R. 
Published: October 2018

SummaryBackgroundControl of equine infectious anaemia (EIA) currently depends on serological diagnosis of infected equids. However, recently infected equids may not produce detectable anti‐EIAV antibodies up to 157 days post infection and so present a high transmission risk. Therefore, direct nucleic acid detection methods are urgently needed to improve EIAV surveillance and management programs in counties where the disease is endemic.ObjectivesTo evaluate a field‐deployable, reverse transcription‐insulated isothermal PCR (RT‐iiPCR) assay targeting the conserved 5′ untranslated region (5′ UTR)/exon 1 of the tat gene of EIAV.Study designThe analytical and clinical performance of the newly developed EIAV RT‐iiPCR was evaluated by comparison with a EIAV real‐time RT‐PCR (RT‐qPCR) along with the AGID test.MethodsAnalytical sensitivity was determined using in vitro transcribed RNA containing the target area of the 5′ UTR/tat gene and samples from two EIAV‐positive horses. Specificity was verified using nine common equine viruses. Clinical performance was evaluated by comparison with EIAV RT‐qPCR and AGID using samples derived from 196 inapparent EIAV carrier horses.ResultsEIAV RT‐iiPCR did not react with other commonly encountered equine viruses and had equivalent sensitivity (95% detection limit of eight genome equivalents), with a concordance of 95.41% to conventional EIAV RT‐qPCR. However, the RT‐qPCR and RT‐iiPCR had sensitivities of 43.75 and 50.00%, respectively, when compared to the AGID test.Main limitationsLow viral loads commonly encountered in inapparent EIAV carriers may limit the diagnostic sensitivity of RT‐PCR‐based tests.ConclusionsAlthough EIAV RT‐iiPCR is not sufficiently sensitive to replace the current AGID test, it can augment control efforts by identifying recently exposed or “serologically silent” equids, particularly as the latter often represent a significant transmission risk because of high viral loads. Furthermore, the relatively low cost and field‐deployable design enable utilisation of EIAV RT‐iiPCR even in remote regions.
Pyrrolizidine alkaloids in commercial feedstuffs for horses
Authors: Rückert C. , Emmerich I. , Hertzsch R. , Vervuert I. 
Published: October 2018

SummaryBackgroundPyrrolizidine alkaloids are secondary plant metabolites with hepatotoxic effect in humans and several animal species. In recent studies, foods such as herbal teas and honey have been found to be contaminated with pyrrolizidine alkaloids.ObjectivesThe aim of this study was to identify and assess pyrrolizidine alkaloids in compound feeds manufactured for horses and containing either alfalfa or a blend of herbs.MethodsForty‐eight feed products for horses were included in the study. The feedstuffs were analysed for 28 selected pyrrolizidine alkaloids by liquid chromatography‐mass spectrometry. The concentrations of the individual pyrrolizidine alkaloids were summed to calculate the total pyrrolizidine alkaloid content.ResultsIn 7 of 48 samples, pyrrolizidine alkaloid concentrations were below the limit of quantification of 1–5 μg/kg. The median of 41 out of 48 samples was 58 μg/kg, and the 25 and 75th percentiles were 8 and 151 μg/kg. The highest observed pyrrolizidine alkaloid concentrations, 1306 and 1222 μg/kg, were found in two alfalfa‐based feed products, followed by 836 μg/kg in an herb‐containing feed product. Lycopsamine, seneciphylline, seneciphylline‐N‐oxide, senecionine and senecionine‐N‐oxide were the most frequently detected alkaloids.Main limitationsRisk assessment was based on no‐observed‐adverse‐effect‐level for pyrrolizidine alkaloids in rats and humans. The specific susceptibility of horses to pyrrolizidine alkaloids remains unknown.ConclusionsAccording to our risk assessment, pyrrolizidine alkaloid contamination should be limited to <90 μg/kg in equine compound feeds. We showed a high rate of pyrrolizidine alkaloids contamination in feed products for horses. In 43% of the analysed samples, pyrrolizidine alkaloid levels exceeded the calculated maximum tolerable levels. There is a need to introduce measures to reduce pyrrolizidine contamination in equine feedstuffs.
The Summary is available in Portuguese – see Supporting Information
Implementing a fuzzy expert system for ensuring information technology supply chain
Authors: Shokouhyar Sajjad , Seifhashemi Sudabeh , Siadat Hossein , Ahmadi Mohammad Milad 
Published: October 2018

AbstractIn the business environment, information technology (IT) plays an important role for firms' performance. It provides information flow that makes the supply chain more robust and resilient without undermining its efficiency. Smart systems use artificial intelligence methods for solving problems and facilitating decision‐making through rule‐based deduction. Accordingly, these systems can present specialists' skills and simulate their thinking process. The primary goal of expert systems is to implement knowledge acquisition process by converting knowledge to wisdom. This process is vital for critical decision‐making regarding important issues such as determining necessities of a particular contract. Companies use professional liability insurance of the products and services to ensure the purchasers and prevent potential losses. Although this practice is highly prevalent, there is not any particular procedure for measuring necessities of contracts. The main purpose of this paper is to design a fuzzy expert system for measuring the necessities of professional contracts regarding insurance coverage and improve the supply chain management using IT. This system can measure and report these obligations, considering specifications of each project. Taking into perspective variety of professional services/products, we consider software as a type of professional contracts, extract its important indices and give it to the system as the input. After the necessary stages, the system produces a proper response and presents the generated response to the user. The software of this expert system is web based, and there are four operating layers in its architecture. We implemented this program in MS Visual Studio Framework with C#.NET programming language. Moreover, we implemented MS SQL‐Server Database Management.
Estimating time and score uncertainty in generating successful learning paths under time constraints
Authors: Nabizadeh Amir Hossein , Jorge Alípio Mário , Leal José Paulo 
Published: October 2018

AbstractThis paper addresses the problem of course (path) generation when a learner's available time is not enough to follow the complete course. We propose a method to recommend successful paths regarding a learner's available time and his/her knowledge background. Our recommender is an instance of long term goal recommender systems (LTRS). This method, after locating a target learner in a course graph, applies a depth‐first search algorithm to find all paths for the learner given a time limitation. In addition, our method estimates learning time and score for all paths. It also indicates the probability of error for the estimated time and score for each path. Finally, our method recommends a path that satisfies the learner's time restriction while maximizing expected learning score. In order to evaluate our proposals for time and score estimation, we used the mean absolute error and average MAE. We have evaluated time and score estimation methods, including one proposed in the literature, on two E‐learning datasets.
Long‐term changes in the impacts of global warming on leaf phenology of four temperate tree species
Authors: Chen Lei , Huang Jian‐Guo , Ma Qianqian , Hänninen Heikki , Tremblay Francine , Bergeron Yves 
Published: October 2018

AbstractContrary to the generally advanced spring leaf unfolding under global warming, the effects of the climate warming on autumn leaf senescence are highly variable with advanced, delayed, and unchanged patterns being all reported. Using one million records of leaf phenology from four dominant temperate species in Europe, we investigated the temperature sensitivities of spring leaf unfolding and autumn leaf senescence (ST, advanced or delayed days per degree Celsius). The ST of spring phenology in all of the four examined species showed an increase and decrease during 1951–1980 and 1981–2013, respectively. The decrease in the ST during 1981–2013 appears to be caused by reduced accumulation of chilling units. As with spring phenology, the ST of leaf senescence of early successional and exotic species started to decline since 1980. In contrast, for late successional species, the ST of autumn senescence showed an increase for the entire study period from 1951 to 2013. Moreover, the impacts of rising temperature associated with global warming on spring leaf unfolding were stronger than those on autumn leaf senescence. The timing of leaf senescence was positively correlated with the timing of leaf unfolding during 1951–1980. However, as climate warming continued, the differences in the responses between spring and autumn phenology gradually increased, so that the correlation was no more significant during 1981–2013. Our results further suggest that since 2000, due to the decreased temperature sensitivity of leaf unfolding the length of the growing season has not increased any more. These finding needs to be addressed in vegetation models used for assessing the effects of climate change.
Oral administration of antibiotics results in fecal occult bleeding due to metabolic disorders and defective proliferation of the gut epithelial cell in mice
Authors: Sonoda Akira , Kamiyama Naganori , Ozaka Sotaro , Gendo Yoshiko , Ozaki Takashi , Hirose Haruna , Noguchi Kaori , Saechue Benjawan , Sachi Nozomi , Sakai Kumiko , Mizukami Kazuhiro , Hidano Shinya , Murakami Kazunari , Kobayashi Takashi 
Published: October 2018

AbstractAntibiotics sometimes exert adverse effects on the pathogenesis of colitis due to the dysbiosis resulting from the disruption of gut homeostasis. However, the precise mechanisms underlying colitogenic effects of antibiotic‐induced colitis are largely unknown. Here, we show a novel murine fecal occult bleeding model induced by the combinatorial treatment of ampicillin and vancomycin, which is accompanied by an enlarged cecum, upregulation of pro‐inflammatory cytokines IL‐6 and IL‐12, a reduction in Ki‐67‐positive epithelial cell number and an increase in the apoptotic cell number in the colon. Moreover, gas chromatography–tandem mass analysis showed that various kinds of metabolites, including glutamic acid and butyric acid, were significantly decreased in the cecal contents. In addition, abundance of butyric acid producer Clostridiales was dramatically reduced in the enlarged cecum. Interestingly, supplementation of monosodium glutamate or its precursor glutamine suppressed colonic IL‐6 and IL‐12, protected from cell apoptosis and prevented fecal occult blood indicating that the reduced level of glutamic acid is a possible mechanism of antibiotic‐induced fecal occult bleeding. Our data showed a novel mechanism of antibiotic‐induced fecal occult bleeding providing a new insight into the clinical application of glutamic acid for the treatment of antibiotic‐induced colitis.
The diagnostic use of ADVIA 2120i Siemens and an “APL criteria” can help to reduce the rate of early death in the APL
Authors: Rocco Vincenzo , Castelli Christian , Fumi Maurizio , Mancini Francesca , Pancione Ylenia , Prisciandaro Michele , Sale Silvia , Tanca Donatella , Vagnoni Davide 
Published: October 2018

AbstractIntroductionAcute promyelocytic leukemia (APL) is a type of acute myeloid leukemia (AML) with a life‐threatening coagulopathy. Once it is suspected, ATRA should be started. Appreciation of APL details is critical, but an experienced hematopathologist may not be available. We developed an algorithm, based on the parameters generated by automated blood cell counter ADVIA 2120i Siemens that can aid the diagnosis of APL.MethodsAll parameters in the algorithm were selected on the bases of the pathophysiology of the APL and the analyzer's technology. We used c1 cutoff: PLT < 150 × 103; % Mono<10; % LUC<4; % hyperchromic cells > 2; %saturated cells ≥ 1; % blasts > 4. Satisfying at least five of six cutoffs, we obtained an “APL criteria”. It was tested on 247.209 raw‐data from routine and emergency samples and on 124 raw‐data from APL. We performed a multiparametric analyses and obtained definitive cutoffs (c2). It was validated on a new group of 51.002 raw‐data from routine and emergency. Finally, it was tested on AML and ALL, MDS, MPN, oncologic samples, and hemolytic and megaloblastic anemia.ResultsThe algorithm provided a high sensitivity (86.30%) and high specificity (99.83%) in APL with high or normal number of WBC and satisfactory results in APL with cytopenia (80%). The specificity was very high also in groups of hematological and nonhematological diseases. It can be used as an “APL criteria” to alert pathologists of the possible presence of APL. It together with instrumental and classical morphology may allow to reduce the time of diagnosis with further reduction in early death.
Perceived job stress among community nurses: A multi‐center cross‐sectional study
Authors: Guo Hongxia , Ni Chunping , Liu Changqing , Li Jiping , Liu Suzhen 
Published: October 2018

AbstractAimChina is reforming its health care system, which aimed to strengthen primary health care through building community health centers (stations) and assigning a “gate‐keeper” role to primary care providers. Community nurses play a key role in the reform. Little is known about the level of job stress among community nurses. Thus, this study aims to explore the level of perceived job stress and its influencing factors among community nurses.MethodA cross‐sectional design was used to conduct a survey with 1015 nurses from 56 community health centers in Sichuan province. Job stress was measured by the Community Nurses Stress Scale. Data were collected between March and November 2015.ResultsCommunity health nurses in China perceived high levels of job stress. The job stress was related to nurses' individual characteristics and work environments. Permanently employed nurses, shift workers, and those older than 45 years age and with less training related to community nursing and involvement in childcare were more likely to experience high levels of stress.ConclusionReform is required of the community nursing personnel system, and development of continuing education programs and stress‐alleviating measures to reduce community nurses' job stress. The results of this study favour future advanced practice community health nursing practice and education.
An interpretive phenomenological study of recovering from mental illness: Teenage girls' portrayals of resilience
Authors: Shalanski Leah , Ewashen Carol 
Published: October 2018

AbstractIn this interpretive phenomenological study, understandings of resilience from the perspective of teenage girls recovering from mental illness were explored. The primary research question was as follows: How is resilience portrayed through teen girls' experiences of health and mental illness? Benner's interpretive phenomenology informed by Gadamerian concepts of conversation, prejudices, and fusion of horizons guided the research design. The interpretive description process involved close reading of how the world experienced by participants was understood while listening for relational, gendered and cultural nuances. Resilience for teenage girls recovering from mental illness was portrayed as very challenging yet a rewarding life path with complex lines of movement towards strength and wellness. The life path involved critical junctures and personal growth while withstanding multiple traumas and acting to overcome adversities. Findings from this study underscore for nurses the relevance of actively advocating for trauma‐informed and gender‐sensitive approaches to promote teenage girls' (mental) health and well‐being and to enhance resilience and recovery from mental illness in the face of what may seem insurmountable adversities.
Preparation of optical media with NIR luminescent Bi+ impurity centers by ion exchange
Authors: Romanov Alexey N. , Haula Elena V. , Kouznetsov Mikhail S. , Lisitsky Igor S. , Pimkin Nikita A. , Boldyrev Kirill N. , Sereda Andrei E. , Shashkin Dmitry P. , Korchak Vladimir N. 
Published: October 2018

AbstractSingle crystal of TlCl was doped with NIR photoluminescent univalent bismuth cations by prolonged immersion in liquid bismuth metal. The ion exchange Tl+ + Bi0 ↔ Tl0 + Bi+ at the crystal surface with subsequent Bi+ migration to the bulk are expected to drive the doping process. Contrary with Bi‐doped TlCl crystals, grown by Bridgman method, the ion exchange does not produce the additional nonluminescent bismuth‐containing centers. The investigation of photoluminescence emission and excitation spectra lead to the conclusion, that Bi+ is the main NIR emissive center in Bi‐doped TlCl.
A review of the frequency and nature of adaptations to cognitive behavioural therapy for adults with Intellectual Disabilities
Authors: Surley Laura , Dagnan Dave 
Published: October 2018

AbstractBackgroundThere is increasing evidence that cognitive behavioural therapy (CBT) can be effective for people with intellectual disabilities. The aim of this review was to report the nature and frequency of adaptations reported in studies ofCBTfor people with intellectual disabilities.MethodThis review updated and extended a previous review by (Whitehouse et al. 2006, J Appl Res Intellect Disabil, 19, 55), which used a framework of adaptations developed by (Hurley et al., 1998, J Dev Phys Disabil, 10, 365). Adaptations included simplification, language, activities, developmental level, use of directive style, flexible methods, involve caregivers, transference/countertransference and disability/rehabilitation approaches. A search identified peer‐reviewed papers that reported individualCBTinformed psychological interventions for people with an Intellectual Disability.ResultsThe search identified 23 studies which met the inclusion criteria for review. Studies reported the majority of the categories of adaptation described by (Hurley et al., 1998, J Dev Phys Disabil, 10, 365).ConclusionsThe results suggest that the framework of adaptations needs further development to increase sensitivity in identifying and categorizing adaptations ofCBT. Increased, systematic reporting of adaptations to studies ofCBTwith people with intellectual disabilities is recommended.
Health problems of people with intellectual disabilities in Dutch out‐of‐hours primary care
Authors: Heutmekers Marloes , Naaldenberg Jenneken , Verheggen Sabine A. , Assendelft Willem J. J. , van Schrojenstein Lantman‐de Valk Henny M. J. , Tobi Hilde , Leusink Geraline L. 
Published: October 2018

AbstractBackgroundLittle is known about the health needs of people with intellectual disabilities who access out‐of‐hours primary care services, raising concerns about accessibility and quality of care for this group. This study aims to identify commonly presented health problems of people with intellectual disabilities in this specific setting compared with the general population.MethodCross‐sectional study with routine data at two out‐of‐hours cooperatives with a total of 41,166 persons aged 20–65 requesting outof‐hours primary care in 2014, of which 315 persons were identified as having an intellectual disability.ResultsHaving an intellectual disability was associated with a higher probability of presenting with epilepsy (OR 45.65) and concerns about, and adverse effects of, medical treatment (OR 23.37, and 8.41, respectively).ConclusionsGiven the high rates of epilepsy and medication‐related concerns of people with intellectual disabilities, this study suggests that these issues require special attention to improve the accessibility and quality of out‐of‐hours primary care.