bluuebunny/crossref_metadata_2025_split huggingface dataset:
Divergent Hypoglycemic Effects of Hepatic-Directed Prandial Insulin: A 6-Month Phase 2b Study in Type 1 Diabetes
Authors: Klonoff David , Bode Bruce , Cohen Nathan , Penn Marc , Geho W. Blair , Muchmore Douglas B. 
Published: September 2019

OBJECTIVE
Hepatic-directed vesicle insulin (HDV) uses a hepatocyte-targeting moiety passively attaching free insulin, improving subcutaneous insulin’s hepatic biodistribution. We assessed HDV-insulin lispro (HDV-L) versus insulin lispro (LIS) in type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS
Insulin Liver Effect (ISLE-1) was a 26-week, phase 2b, multicenter, randomized, double-blind, noninferiority trial.

RESULTS
Among 176 randomized participants (HDV-L n = 118, LIS n = 58), the difference in change from baseline A1C was 0.09% (95% CI −0.18% to 0.35%), confirming noninferiority (prespecified margin ≤0.4%). Overall, there were no statistically significant differences between treatments for hypoglycemia or insulin dosing. However, baseline A1C modified the treatment group effect (interaction P &lt; 0.001) on clinically apparent hypoglycemia designated by treatment-blinded investigators as severe. Thus, at higher baseline A1C, there was less hypoglycemia and lower insulin dosing with similar A1C outcomes during HDV-L versus LIS, whereas greater risk of hypoglycemia despite similar A1C outcomes and insulin doses was observed with lower baseline A1C. Among poorly controlled participants (A1C ≥8.5%), incidence rates of severe hypoglycemia in the HDV-L and LIS arms were 69 and 97 events/100 person-years, respectively (P = 0.03), whereas with A1C &lt;8.5%, respective rates were 191 and 21 events/100 person-years (P = 0.001). Similar A1C-dependent trends in hypoglycemia were seen with continuous glucose monitoring. Among poorly controlled participants, bolus insulin doses at end point were ∼25% lower with HDV-L (P = 0.02), despite similar A1C outcomes; in better-controlled participants, insulin doses and A1Cs were stable over time in both subgroups. No safety signals were identified.

CONCLUSIONS
Hepatic biodistribution of HDV-L appears to potentiate insulin effect in T1D, with divergent clinical outcomes in hypoglycemia dependent on baseline A1C.
Visit-to-Visit Fasting Glucose Variability in Young Adulthood and Hippocampal Integrity and Volume at Midlife
Authors: Xiong Zhenyu , Li Jiaying , Zhong Xiangbin , Zhang Shaozhao , Sun Xiuting , Zhou Huimin , Chen Yunzhi , Zhuang Xiaodong , Liao Xinxue 
Published: September 2019

OBJECTIVE
To determine whether visit-to-visit fasting glucose (VVFG) variability in young adulthood is associated with midlife hippocampal integrity and volume.

RESEARCH DESIGN AND METHODS
Multivariable-adjusted linear regression models were used to estimate the association between VVFG variability and brain MRI variables in 543 CARDIA study participants. VVFG variability was defined by the SD of FG (SDFG), the coefficient of variation of the mean FG (CVFG), and the average real variability (ARVFG) over 25 years of follow-up. Hippocampal integrity fractional anisotropy (FA) and tissue volume standardized to intracranial volume were measured by 3T MRI at year 25.

RESULTS
After multivariable adjustment, higher FG variability (1-SD increase) was associated with lower hippocampal FA (SDFG −0.015 [95% CI −0.026, −0.004]; CVFG −0.009 [95% CI −0.018, −0.001]; ARVFG −0.011 [95% CI −0.019, −0.002]) and lower hippocampal volume (SDFG −0.012 [95% CI −0.023, −0.001]).

CONCLUSIONS
Higher VVFG variability in young adulthood is associated with lower midlife hippocampal integrity and volume, suggesting its value in predicting risk for hippocampal structural damage.
Makna Female Masculinity dalam Kostum Wayang Srikandi Red Batik Solo
Authors: Azizah Farah Nur , Wirawanda Yudha 
Published: September 2019

This research is a study about the meaning of female masculinity in fashion. The object of analysis is the Javanese figure, Dewi Srikandi in the Red Batik Solo Costume Carnival. This Javanese figure, Dewi Srikandi is interesting to study because she has strong myths about masculinity. Beside that, the researcher also interested in how this female warrior figure looks masculine which is observed from the costumes and accessories worn. The purpose of this study is to find out how does Dewi Srikandi gives the meaning by the costume into the visual of the Red Batik Solo carnival. The analysis uses semiotics Roland Barthes with a qualitative approach and the theory of Female Masculinity Halberstam. The analysis shows that Srikandi is a female character or role that has masculine characteristics that can be observed from analysis of the color, meaning of denotation and connotation and also meaning of myth, such as red, black, white, brown and dark colors. Masculine also can be shown from Srikandi costumes which are related with syntagmatic and paradigmatic, such as red can be replaced with dark colors (black or brown). In addition, costume accessories such as ricikan (crown, sumping, necklace, bracelet, belt or belt, arrow, and shoes) also give masculine meaning which are indicated by the characteristics of masculine generally, for example strength, courage, aggressiveness, leadership, assertiveness, domination, and violence. Penelitian ini menganalisis mengenai makna Female Masculinity. Objek penelitian ini pada kostum wayang Srikandi yang dibuat oleh Red Batik Solo. Tokoh wayang Jawa Dewi Srikandi ini menarik untuk diteliti karena mempunyai mitos yang kuat tentang karakter wanita yang memiliki sisi maskulin. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana makna yang disampaikan Dewi Srikandi kedalam bentuk visual fashion kostum karnaval Red Batik Solo. Analisis yang digunakan adalah analisis semiotika oleh Roland Barthes dengan pendekatan kualitatif dan teori Female Masculinity Halberstam. Selain itu, peneliti juga tertarik tentang bagaimana tokoh prajurit wanita ini terlihat maskulin yang diamati dari kostum dan aksesoris yang dikenakan. Hasil analisis menunjukkan bahwa Srikandi adalah tokoh puteri yang memiliki sifat maskulin yang dapat diamati dari analisis warna, makna denotasi dan konotasi serta makna mitos, seperti warna merah, hitam, putih, coklat dan warna gelap. Sifat maskulin juga dapat ditunjukkan dari kostum Srikandi yang dihubungkan dengan sintagmatik dan paradigmatik, seperti warna merah dapat diganti dengan warna gelap (hitam atau coklat). Selain itu, aksesoris kostum seperti ricikan (mahkota, sumping, kalung, gelang, ikat pinggang atau sabuk, panah, dan sepatu) juga memberi makna maskulin yang ditunjukkan dari karakteristik yang umumnya dianggap maskulin, misalnya menunjukkan kekuatan, keberanian, agresivitas, kepemimpinan, ketegasan, dominasi, dan kekerasan.
BEYOND ALLIANCE FOR KNOWLEDGE FROM HAMK’S POINT OF VIEW
Authors: Puusaari Pertti , Ahokallio-Leppälä Heidi , Salminen Janne 
Published: September 2019

ABSTRACTLong term cooperation that is based on common trust, friendship and especially willingness to go forward together is a good basis for development of an international university. Challenging the modern world together makes it possible to reach goals beyond the average. This is the heart of the Beyond Alliance for Knowledge—an alliance between Feevale University, VIA University College and Häme University of Applied Sciences (HAMK). This article is written to highlight the basic needs for the Beyond Alliance for Knowledge from HAMK’s perspective. The perspectives are (1) the need for internationalisation of the university itself, (2) better education products for students and (3) effective research results for businesses and society. The ultimate goal in this alliance should be to develop competences which we need to challenge global wicked problems.Keywords: Alliance. Education. Competence. Co-operation. Research. RESUMOA cooperação de longo prazo, baseada na confiança comum, na amizade e especialmente na disposição de avançar juntos, é uma boa base para o desenvolvimento de uma universidade internacional. Desafiando o mundo moderno juntos, é possível alcançar objetivos além da média. Este é o coração da Beyond Alliance for Knowledge - uma aliança entre a Universidade Feevale, a VIA University College e a Häme University of Applied Sciences (HAMK). Este artigo foi escrito para destacar as necessidades básicas da Beyond Alliance for Knowledge na perspectiva da HAMK. As perspectivas são (1) a necessidade de internacionalização da própria universidade, (2) melhores produtos de educação para os estudantes e (3) resultados efetivos de pesquisa para empresas e sociedade. O objetivo final desta aliança deve ser o desenvolvimento de competências que precisamos para desafiar os complexos problemas globais.Palavras-chave: Aliança. Educação. Competência. Cooperação. Pesquisa.
THE RELATIONSHIP OF HOSPITAL COST, SERVICE QUALITY AND PATIENT SATISFACTION
Authors: Arsita Riska , Idris Haerawati 
Published: September 2019

Customer satisfaction becomes very important to determine the success of service companies. One way to survive in the healthcare industry today is to create customer satisfaction through improved service quality. Hospital cost is an indicator for patients to utilize health services. This study aims to analyze the relationship of hospital cost and service quality with patient satisfaction. This study used analytic survey with a cross-sectional study design. The sample of this study is the general patient who used inpatient and outpatient installation of Bhayangkara Hospital in Palembang as many as 117 patients. The sampling technique used systematic random sampling. Analysis of statistical data used the t-test. The results showed that the quality of service has a significant relationship with patient satisfaction (p-value 0,001). While the hospital cost does not have a significant relationship with satisfaction patients (p-value 0,368). Service quality has relationship with patient satisfaction. The hospital should improve dimension of service quality in order to improve patient satisfaction.
Keywords: Cost, service quality, patient satisfaction
PERBANDINGAN MODEL PEMBELAJARAN DISCOVERI LEARNING DAN MODEL PEMBELAJARAN PROBLEM POSING UNTUK MENINGKATKAN HASIL BELAJAR KONSEP SISTEM PENCERNAAN MAKANAN PADA SISWA KELAS VIII SMP KRISTEN YPKPM AMBON
Authors: Radjangolo Dominggas , Tuaputty H , Arini Ine 
Published: September 2019

Background: The use of the right learning model is an alternative to overcome the problem of students' low absorption of lessons, in order to improve the quality of teaching. In its implementation, an appropriate learning model is needed that is able to arouse students' motivation to learn. The use of the right learning model is to use Discovery Learning models and Problem Posing learning models.
Method: This study aims to determine the differences in student learning outcomes taught using Discovery Learning models and Problem Posing learning models on the concept of the digestive system in the food of class VIII students of YPKPM Christian Middle School Ambon.
Results: Based on the results of the study the use of the Discovery learning model the average value of cognitive aspects = 87.82, the affective aspect = 80.88, the psychomotor aspects = 90.4, the final value = 94.64, the final test value = 94. While the model Problem Posing learning the average value on cognitive aspects = 95.49, affective aspects = 93.76, psychomotor aspects = 93.32, final value = 93.90 and final test value = 96.17. With t count 2.04 and t table 2.01.
Conclusion: Student learning outcomes in the problem posing learning model class are higher than students in the class of discovery learning models.
ОБРАЗ І СИМВОЛ КВІТУЧОГО ДЕРЕВА У МИСТЕЦТВІ КИТАЮ І ЄВРОПИ
Authors: Лай Юеге 
Published: September 2019

The purpose of the study is to reveal the figurative and symbolic parallels of the image of a flowering tree in the art of China and Europe. When studying the topic chosen by us, it was especially important to use a comparative method, which allows comparing works of art from Europe and China based on related subjects from different time periods and identifying the general and the particular. The artistic-stylistic and iconological method is actively used. Iconology along with the iconography allows to perceive the symbolic content of the work.
PENGARUH RASIO KEUANGAN DAN PERTUMBUHAN PENDAPATAN TERHADAP RETURN SAHAM PADA PERUSAHAAN PERKEBUNAN DI BURSA EFEK INDONESIA 2010-2017
Authors: Nurmasari Ifa 
Published: September 2019

ABSTRACT Tujuan dari penelitian ini adalah untuk mengetahui apakah terdapat pengaruh yang signifikan antara rasio keuangan (Current Ratio, Return on Equity dan Debt to Equity Ratio) dan pertumbuhan pendapatan terhadap return saham, baik secara parsial maupun simultan. Return saham merupakan tingkat keuntungan yang akan diperoleh investor. Penelitian ini menggunakan teknik purposing sampling, dimana sampel yang diambil adalah data perusahaan yang sudah terdaftar di BEI sejak 1 Januari 2010 dan perusahaan tersebut mencantumkan laporan keuangannya secara lengkap. Data dalam penelitian ini adalah data panel, yaitu terdiri dari data cross section (7 perusahaan perkebunan) dan data time series (8 tahun). Data akan diolah dengan menggunakan eview versi 10. Pada penelitian ini dilakukan berbagai uji, yaitu : uji estimasi model regresi linier, uji asumsi klasik dan uji hipotesis. Hasil penelitian menunjukkan bahwa secara parsial, CR, ROE dan pertumbuhan pendapatan tidak berpengaruh signifikan terhadap return saham. Sedangkan DER berpengaruh negatif signifikan terhadap return saham. Rasio keuangan (CR, ROE, DER) dan pertumbuhan pendapatan secara simultan berpengaruh signifikan terhadap return saham, sebesar 29%.
PENGARUH KEGIATAN SOSIALISASI KPU TERHADAP SIKAP MAHASISWA PADA KEGIATAN PEMILU
Authors: Suherman Muhammad Tanziil , Amirulloh M Rijal 
Published: September 2019

ABSTRACT
The research is entitled “The Influence of General Election Commision toward Student Attitude on Election Activity”. Research method applies quantitative with path analysis. Research aims to know how big the influence of socialization activity source factor toward student attitude on election activity, to know how big the influence of message factor, and to know how big the influence of subject receiver factor toward student attitude on election activity.
The result research shows that each variable has sifnificant influence toward student attitude on election activity. Source factor variable has significant influence toward student attitude as much as 78,9 %, socialization message factor variable has significant influence toward student attitude as much as 85,5%, subject receiver factor has sifnificant influence toward student attitude as much as 81,1%. Message variable becomes the most influence variable toward student attitude on election activity.
It can be concluded that message factor variable has the most influence factor compares to other factor. Sending factual message based on fact, sending a trending topic message, and such message is thought to be important so that message can change someone attitude toward something. Besides, source factor has an influence. Cridible factor and expert can make communicant believe and enable to be persuaded well especially previous attitude will be able to convinced to change.
KOMUNIKASI INTERPERSONAL PADA PROSES PENDIDIKAN POLITIK PEMILIH PEMULA
Authors: Sari Affiyah Tri Yuni , Fitriyani Aissyah Dwi , Said Martriana Ponimin 
Published: September 2019

Political education is one of the important factors in determining the attitude of a voter in the conduct of elections. Beginner voters with low levels of political education tend to have voices that are still floating or called swing-voters. If it is not able to be convinced, the swing-voter can become a golput, but if it can be convinced, the swing-voter can be an additional vote for a candidate or party in the final result of the vote count. The phenomenon of political apathy can be reduced by providing political education to beginner voters, one of the methods is through interpersonal communication. The exchange of values ??that form the basis of interpersonal communication can also occur in the family. This study aims to determine how the role of interpersonal communication in the process of early voter political education. Using the interpretative paradigm and descriptive qualitative research methods, by conducting observations, interviews and documentation studies. The unit of analysis under study is individuals, namely beginner voters at Pramuka Island, Thousand Islands, DKI Jakarta Province. The results of the study show that the role of interpersonal communication in the process of political voter education at Pramuka Island is to conduct discussions, exchange information about politics, and conduct political socialization, this will affect the process of political voter education and political participation in the 2019 Election.
Keywords: interpersonal communication; political education; beginner voters; general election
PENGARUH BUDAYA KERJA DAN PARTISIPASI KERJA TERHADAP KINERJA PEGAWAI DINAS PENDIDIKAN KABUPATEN INDRAMAYU
Authors: Kurniawan Pebi , Saâ€™adah Saâ€™adah 
Published: September 2019

Tujuan penelitian ini adalah untuk mengetahui Pengaruh Budaya Kerja dan Partisipasi Kerja Terhadap Kinerja Pegawai Dinas Pendidikan Kabupaten Indramayu.
Populasi penelitian ini adalah semua pegawai di Dinas Pendidikan Kabupaten Indramayu sebanyak 60 orang. Sampel penelitian ini sebanyak 47 orang. Sumber data dalam penelitian ini adalah data primer. Data dikumpulkan dengan menggunakan metode survey melalui penyebaran kuesioner secara langsung. Metode analisis data yang digunakan yaitu analisis regresi berganda dan pengujian data yang dilakukan dengan dibantu oleh program SPSS 19.
Berdasarkan hasil analisis data penelitian dapat disimpulkan bahwa: (1) Peran Budaya kerja berpengaruh terhadap pencapaian kinerja pegawai. Hasil penelitian ini konsisten dengan penelitian yang dilakukan oleh Aryanto et.al (2013) dan Safrizal et. Al (2004), (2) Penerapan partisipasi kerja berpengaruh terhadap pencapaian kinerja pegawai. Hasil penelitian ini mendukung hasil penelitian yang dilakukan oleh Fajrin (2010) dan Suprayitno (2013), (3) Peran budaya kerja dan penerapan partisipasi kerja berpengaruh terhadap pencapaian kinerja pegawai (Y).
Kata kunci : Budaya kerja, partisipasi kerja, kinerja pegawai
PENGARUH HARGA DAN KUALITAS PELAYANAN DISTRIBUTOR TERHADAP KEPUASAN KONSUMEN PENGECER PADA PERUSAHAAN CONSUMER GOODS (Studi pada PT, TigaraksaSatriaTbk. Kota Cirebon)
Authors: Djadjuli M. , Juanda Hilman 
Published: September 2019

Kepuasan konsumen akan terbentuk jika dapat memenuhi harapan-harapan dasar konsumen. Banyak faktor yang mempengaruhi kepuasan konsumen, diantaranya harga produk dan kualitas pelayanan. Penelitian ini bertujuan untuk mengetahui, mengkaji dan menganalisis : (1) pengaruh harga terhadap kepuasan konsumen PT. Tigaraksa Satria Kota Cirebon, (2) pengaruh kualitas pelayanan terhadap kepuasan konsumen PT. Tigaraksa Satria Kota Cirebon, dan (3) menganalisis pengaruh harga dan kualitas pelayanan terhadap kepuasan konsumen PT. Tigaraksa Satria Kota Cirebon. Penelitian dilakukan pada PT. Tigaraksa Satria Tbk., dari bulan Januari sampai Februari 2018.
Desain penelitian yang digunakan dalam penelitian ini adalah penelitian kuantitatif, dengan teknik penelitian survey deskriptif. Pengumpulan data primer diperoleh melalui wawancara dengan konsumen pengecer PT. Tigaraksa Satria Tbk. Cirebon sebagai responden menggunakan daftar pertanyaan, dan data sekunder diperoleh dari instansi yang ada kaitannya dengan penelitian ini. Untuk mengetahui pengaruh harga produk dan kualitas pelayanan terhadap kepuasan pengecer digunakan analisis regresi linier berganda.
Hasil penelitian menunjukkan bahwa : (1) Harga produk secara parsial berpengaruh negatif dan signifikan terhadap kepuasan konsumen pengecer. Hal ini menunjukan bahwa semakin baik harga produk (murah), maka akan meningkatkan kepuasan konsumen pengecer, (2) Kualitas pelayanan secara parsial berpengaruh positif dan signifikan terhadap kepuasan konsumen pengecer. Hal ini menunjukan bahwa semakin baik kualitas pelayanan yang diberikan, maka akan meningkatkan kepuasan konsumen pengecer, dan sebaliknya jika kualitas pelayanan yang diberikan kurang baik, akan menurukan kepuasan konsumen pengecer, dan (3) Harga produk dan kualitas pelayanan secara simultan (bersama-sama) berpengaruh positif dan signifikan terhadap kepuasan konsemen pengecer. Peningkatan kualitas pelayanan yang baik dan penetapan harga produk yang tercangkau konsumen dapat meningkatkan kepuasan konsumen pengecer.
Kata Kunci : Harga, Kualitas Pelayanan dan Kepuasan Konsumen
Construção e avaliação de um museu virtual dos resíduos sólidos
Authors: Lúcia Rech Stedile Nilva , Rafael Faraco Giacomoni Rui 
Published: September 2019

As tecnologias da informação permitiram a humanidade construir museus na dimensão virtual. O presente artigo relata a experiência da construção de um site para abrigar o Museu Virtual Resíduos Sólido (MVRS) na área das Engenharias e Ciências Ambientais. A construção do site do MVRS foi dividida em duas etapas, (Revisão bibliográfica, Processo de construção do Museu), sendo a segunda dividida em cinco etapas (Elaboração de um fluxograma, Definição da organização do Museu e dos conceitos que o compõem, Processo de elaboração do site MVRS, Avaliação do MVRS e Socialização do MVRS). A avaliação do MVRS, mostrou que a construção do site do MVRS foi bem aceita pelo público. Destaca-se a necessidade de monitoramento e avaliação constante do Museu, como forma de garantir sua eficácia.
A Boy With Suspicion of Type V Glycogen Storage Disease
Authors: Mexitalia Maria , Pinilih Astri 
Published: September 2019

Latar belakang : Glycogen storage disease subtipe V (GSD-V; penyakit McArdle; defisiensi miofosforilase; defisiensi fosforilase glikogen otot) disebabkan oleh mutasi pada gen fosforilase glikogen otot. Gejala klinis biasanya dimulai pada saat remaja awal dengan intoleransi latihan dan kekakuan otot. Mioglobinuria transien terjadi akibat rhabdomiolisis setelah latihan dan dapat menyebabkan gagal ginjal akut.
Kasus : Seorang anak laki-laki, usia 13 tahun dirujuk ke Rumah Sakit Dr.Kariadi dengan keluhan bengkak seluruh tubuh, urine berwarna hitam, demam, kaku pada jari-jari dan tidak dapat berjalan. Pemeriksaan fisik menunjukkan edema general, paraparese innferior, paralisis nervus fasialis dan pembesaran lien. MRI kepala dengan kontras menunjukkan lesi multipel di nukleus kaudatus dan putamen bilateral. Hasil histopatologi biopsi hepar adalah penyakit metabolik yang cenderung merupakan kelainan metabolism karbohidrat.
Pembahasan :Hampir seluruh pasien dengan penyakit McArdle menunjukkan intoleransi latihan, seperti mudah lelah, nyeri otot, kontraktur dan mioglobinuria yang dipicu oleh latihan. Diagnosis definitif adalah berdasarkan pemeriksaan histokimiawi otot dengan tidak ditemukannya enzim fosoforilase otot. Penyakit McArdle tidak dapat disembuhkan dan tidak ada terapi khusus yang direkomendasikan.
Simpulan : Pasien didiagnosis dengan kecurigaan glycogen storage disease tipe V.. Pasien mendapatkan terapi nutrisi suplementasi vitamin B6, vitamin B12 dan fisioterapi. Terdapat beberapa pemeriksaan yang belum dapat dilakukan selama perawatan, yaitu forearm ischemic exercise, evaluasi mioglobinuria, kreatinin kinase dan analisis genetika.
Kata kunci : GSD tipe V, anak, penyakit metabolik