bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumer behaviour and the toilet: Research on expulsive and retentive personalities
Authors: Guido Gianluigi , Belk Russell W. , Rizzo Cristian , Pino Giovanni 
Published: March 2018

AbstractDuring the last five decades, a number of studies have attempted to draw from psychoanalytic theory to examine the relationship between evacuation disorders and a person's character. According to Freud's original conceptualization, early or harsh toilet training leads children to develop an anal retentive personality, characterized by the tendency to control their bowels as well as their material possessions; by contrast, liberal toilet training leads children to develop an anal expulsive personality, characterized by the tendency to excessively relieve faeces, as well as be being careless, messy, and inclined to dispose of old products and buy new ones. Although toilet training may not be responsible, these sets of traits do cohere. To empirically examine these hypotheses, we studied the personality traits and consumption habits of people suffering from different bowel disorders. By means of semistructured interviews, we analysed the personality characteristics, sociodemographic backgrounds, and peculiar consumption habits of people suffering from constipation and diarrhoeic syndromes. The results show that constipated people tend to be obstinate, excessively concerned with hygiene, and inclined toward retaining possessions, whereas diarrhoeic people tend to be careless, disorganized, and disposed to share their possessions with others. We discuss the theoretical and practical implications of these results and indicate avenues for future research.
Alone but together, autonomous but related: Self‐construal effects on happiness in social experiences
Authors: Merdin‐Uygur Ezgi , Hesapci Ozlem 
Published: March 2018

AbstractCommunal tables and open workspaces have become popular servicescapes, that is, contemporary spaces for experiencing, dining, or working alone but together. Previous research demonstrates that experiencing with close others (e.g., with friends or family) increases happiness and satisfaction, but experiences shared with strangers in contexts such as communal tables or workshops have not yet been thoroughly analyzed. Addressing this research gap from a social–psychological perspective, we suggest that even though individuals are generally happier when they share experiences with loved ones, self‐construal plays a moderating role in the relationship. Individuals with high autonomy and high relatedness do not anticipate greater happiness from experiences shared with friends than with those shared with strangers. Three experimental studies (two online and one field) demonstrate this effect, using different operationalizations of autonomy relatedness. Managerial implications are discussed, and suggestions are made for future research.
U.K. consumers' perceived risk of buying products from emerging economies: A moderated mediation model
Authors: Wang Weiyue , He Hongwei , Sahadev Sunil , Song Wei 
Published: March 2018

AbstractAlthough considerable research has been conducted on consumer attitude towards foreign products, most of these studies focus on the attitude of products from Western developed countries. Our study intends to investigate the effects of consumers' national identification and culture sensitivity on their perceived risk of buying products from Eastern developing countries. Especially, this study advances the literature by identifying the mediation effect of consumer ethnocentrism and the moderating effect of consumer value consciousness. Taking China and India as focal emerging economies, the consumer survey (n = 308) in the United Kingdom produced the following results. First, U.K. consumers' national identification is positively related to their perceived risk of buying Eastern products through consumer ethnocentrism, whereas their cultural sensitivity has a negative relationship. Second, the effect of consumer ethnocentrism on the perceived risk of buying Eastern products is moderated by consumer value consciousness. Third, value consciousness also attenuates the indirect relationships between national identification or cultural sensitivity and perceived risk via consumer ethnocentrism.
Seed Polyphenolic Profile, Antioxidative Activity, and Fatty Acids Composition of Wild and Cultivated Carthamus Species
Authors: Karami Soraya , Sabzalian Mohammad R. , Rahimmalek Mehdi 
Published: March 2018

Total flavonoid content (TFC) and cyanidin‐3‐glucoside (Cyd‐3‐glu) of seed and seed coat extract of 16 genotypes from five species of Carthamus were studied, and their major polyphenolic compounds and antioxidant activity of the seed coat extracts were determined using HPLC analysis and DPPH assay, respectively. Additionally, fatty acids composition of the seed oil was analyzed by GC. In general, TFC and Cyd‐3‐glu content of seed coat extracts were higher than those of seed extracts. A novel breeding line with black seed coat (named A82) depicted lower TFC (3.79 mg QUE/g DW) but higher Cyd‐3‐glu (24.64 mg/g DW) compared to the white and other seed‐pigmented genotypes. DPPH radical scavenging activity showed a strong association with Cyd‐3‐glu content (r = 0.84), but no correlation with TFC (r = −0.32). HPLC analysis of seed coat extracts revealed that four compounds were dominant constituents including rutin (7.23 – 117.95 mg/100 g DW), apigenin (4.37 – 64.88 mg/100 g DW), quercetin (3.09 – 14.10 mg/100 g DW), and ferulic acid (4.49 – 30.41 mg/100 g DW). Interestingly, the genotype A82 with an appropriate polyunsaturated/saturated fatty acids index (5.46%) and a moderate linoleic fatty acid content (64.70%) had higher nutritional and pharmaceutical value than all the other genotypes.
Deciphering the molecular mechanism and apoptosis underlying the in‐vitro and in‐vivo chemotherapeutic efficacy of vanadium luteolin complex in colon cancer
Authors: Roy Souvik , Chakraborty Tania 
Published: March 2018

The present study is carried out to reveal the chemotherapeutic effects of vanadium luteolin complex against HT‐29 human colon carcinoma cell line and chemically induced rat colon carcinoma. Our investigation revealed that the vanadium luteolin complex induces apoptosis in HT‐29 cells in a dose‐dependent manner. Furthermore, the study also confirmed that the vanadium luteolin complex increased caspase‐3 and p53 expression whereas reduced the VEGF, mTOR, Akt expression, and induced DNA fragmentation in HT‐29 cells. The oral acute and sub‐acute toxicity and the DNA binding efficacy of the complex with CT‐DNA were investigated. The vanadium luteolin complex showed mortality at a dose of 120 mg/kg dose. The sub‐acute toxicity of the complex at the dose of 90 mg/kg presented an increased level of WBC count, total bilirubin, ALT, AST, ALP, creatinine, blood urea nitrogen, and decreased level of total protein compared with the control group. Histopathological alterations in kidney, liver, stomach, and lungs was observed at a dose of 90 mg/kg of the complex. The dose of 45 mg/kg of the complex was found to have better chemotherapeutic activity by significantly reducing the incidences of aberrant crypt foci formation, upregulation in the expression of p53 and Bax, and downregulation of the expression of Bcl2, and cell proliferation was found in the complex at a dose of 45 mg/kg. Our findings from the study support that the complex possesses a potential chemotherapeutic activity against colon cancer and was efficient in reducing aberrant crypt foci formation multiplicity, hyperplastic lesions in the colon tissues of rats by inducing apoptosis.SignificanceThe present study demonstrates that the effect of vanadium‐luteolin complex in HT‐29 cells and dimethylhydrazine challenged rats, curtail cell proliferation through induction of apoptosis mediated via activation of the key proteins involved in the intrinsic pathway like p53, Bax, caspase‐3 and downregulating Bcl2, mTOR/Akt, angiogenic factor VEGF along with aberrant crypt foci formation multiplicity, and PCNA in the colon mucosa. Our combinatorial approach shows higher efficacy at considerably lower doses minimizing side effects. Insights into in‐vitro and in‐vivo results provide strong proof that low dose chemotherapeutic regimens can suppress, reverse, or delay the progression of colon cancer by modulating intrinsic apoptotic as well as antiangiogenic pathways.
Microarray Analysis of Oligosaccharide‐Mediated Multivalent Carbohydrate–Protein Interactions and Their Heterogeneity
Authors: Gade Madhuri , Alex Catherine , Leviatan Ben‐Arye Shani , Monteiro João T. , Yehuda Sharon , Lepenies Bernd , Padler‐Karavani Vered , Kikkeri Raghavendra 
Published: March 2018

AbstractCarbohydrate–protein interactions (CPIs) are involved in a wide range of biological phenomena. Hence, the characterization and presentation of carbohydrate epitopes that closely mimic the natural environment is one of the long‐term goals of glycosciences. Inspired by the multivalency, heterogeneity and nature of carbohydrate ligand‐mediated interactions, we constructed a combinatorial library of mannose and galactose homo‐ and hetero‐glycodendrons to study CPIs. Microarray analysis of these glycodendrons with a wide range of biologically important plant and animal lectins revealed that oligosaccharide structures and heterogeneity interact with each other to alter binding preferences.
Facile One‐Step Assembly of Bona Fide SUMO Conjugates by Chemoenzymatic Ligation
Authors: Pawale Vijaykumar S. , Yadav Prity , Roy Rajendra P. 
Published: March 2018

AbstractThe post‐translational conjugation of the small ubiquitin‐like modifiers (SUMOs) to target proteins occurs through a complex machinery that involves sequential action of at least three enzymes. SUMOylation performs crucial regulatory functions in several cellular processes. The availability of well‐defined SUMO conjugates is necessary for untangling the mechanism of SUMOylation. However, assembly of homogeneous SUMO conjugates represents a challenge because of the multi‐step synthesis involved and the unwieldiness of the reconstituted biosynthetic systems. Here we describe a simple one‐step chemoenzymatic strategy for conjugating engineered SUMO (eSUMO) proteins to a prefabricated isopeptide‐linked SUMO target peptide. Notably, the eSUMOs were efficiently recognized by the enzymes of the SUMOylation machinery and the SUMO conjugates served as bona fide substrates for DeSUMOylating enzymes.
Duplex Healing of Selectively Thiolated Guanosine Mismatches through a Cd2+ Chemical Stimulus
Authors: Lunn Samantha M. L. , Hribesh Samira , Whitfield Colette J. , Hall Michael J. , Houlton Andrew , Bronowska Agnieszka K. , Tuite Eimer M. , Pike Andrew R. 
Published: March 2018

AbstractThe on‐column selective conversion of guanosine to thioguanosine (tG) yields modified oligomers that exhibit destabilisation over the fully complementary duplex. Restoration to a stabilised duplex is induced through thio‐directed Cd2+ coordination; a route for healing DNA damage. Short oligomers are G‐specifically thiolated through a modified on‐column protocol without the need for costly thioguanosine phosphoramidites. Addition of Cd2+ ions to a duplex containing a highly disrupted tG central mismatch sequence, 3′‐A6tG4T6‐5′, suggests a (tG)8Cd2 central coordination regime, resulting in increased base stacking and duplex stability. Equilibrium molecular dynamic calculations support the hypothesis of metal‐induced healing of the thiolated duplex. The 2 nm displacement of the central tG mismatched region is dramatically reduced after the addition of a chemical stimuli, Cd2+ ions, returning to a minimized fluctuational state comparable to the unmodified fully complementary oligomer.
Triplex Formation by Oligonucleotides Containing Organomercurated Base Moieties
Authors: Ukale Dattatraya Uttam , Lönnberg Tuomas 
Published: March 2018

AbstractHomothymine oligonucleotides with a single 5‐mercuricytosine or 5‐mercuriuracil residue at their termini have been synthesized and their capacity to form triplexes has been examined with an extensive array of double‐helical targets. UV and circular dichroism (CD) melting experiments revealed the formation and thermal denaturation of pyrimidine⋅purine*pyrimidine‐type triple helices with all oligonucleotide combinations studied. Nearly all triplexes were destabilized upon mercuration of the 3′‐terminal residue of the triplex‐forming oligonucleotide, in all likelihood due to competing intramolecular HgII‐mediated base pairing. Two exceptions from this general pattern were, however, observed: 5‐mercuricytosine was stabilizing when placed opposite to a T⋅A or A⋅T base pair. The stabilization was further amplified in the presence of 2‐mercaptoethanol (but not hexanethiol, thiophenol or cysteine), suggesting a stabilizing interaction other than HgII‐mediated base pairing.
Impact of percutaneous femoral arteriotomy closure using the MANTATM device on vascular and bleeding complications after transcatheter aortic valve replacement
Authors: De Palma Rodney , Settergren Magnus , Rück Andreas , Linder Rikard , Saleh Nawzad 
Published: March 2018

AbstractObjectivesTo evaluate the feasibility of fully percutaneous closure using a novel collagen‐based vascular closure device after transfemoral aortic valve replacement (TAVR).BackgroundTAVR is utilized increasingly for the treatment of severe symptomatic aortic stenosis. Vascular complications related to access and closure dominate the adverse event profile of the procedure despite progressively reducing arteriotomy caliber. The advent of a novel collagen‐based device (MANTATM) and preliminary data suggest this could be used as a routine percutaneous closure device.MethodsA prospective observational study of unselected consecutive patients undergoing TAVR in a single center. Data were collected via hospital electronic records and the SWEDEHEART registry. The primary clinical outcome was closure success and time to hemostasis. Secondary outcomes included VARC‐2 defined major and minor vascular and bleeding complications within 30 days using suture‐based closure with Prostar‐XL within the same center.ResultsA consecutive cohort of 346 patients underwent TAVR via the transfemoral approach. Vascular closure with MANTATM was successful in all with a mean time to hemostasis of 42 sec (SD 115.5, range 0–600). The composite of all‐cause mortality and major complications related to the main access site was similar between the groups (1.1% vs 1.9%, P = .61). Major bleeding occurred less frequently with MANTA TM (1.1% vs 7.8%, P = .02).ConclusionThe novel use of a collagen‐based vascular closure device for large caliber arteriotomy is feasible in an unselected population undergoing transfemoral TAVR and appears efficacious compared to percutaneous suture‐based closure. These data should prompt larger studies to evaluate efficacy and safety.
Effect of sodium alginate on the gelatinization and retrogradation properties of two tuber starches
Authors: Yu Zhen , Wang Yu‐Sheng , Chen Hai‐Hua , Li Qian‐Qian 
Published: March 2018

Background and objectivesThe inherent properties of native starches are undesirable for the industrial applications because of the high tendency of retrogradation. Tuber starches are widely used in starchy foods. However, the gelatinization and retrogradation properties of tuber starches are not much known. This study mainly investigated the gelatinization and retrogradation properties of two tuber starches, potato starch (PS) and sweet potato starch (SPS), with or without the addition of sodium alginate (AG), using rapid visco analyzer, texture analyzer, differential scanning calorimeter, dynamic rheometer, and X‐ray diffractometer. The AG‐starch mixture gel was stored at 4°C for 1–21 days.FindingsThe results showed that the addition of AG increased the gelatinization temperature of the two tuber starches, suggesting the gelatinization process was delayed by the addition of AG. The addition of AG obviously decreased the setback (SB) value, while increased the tanδ values of the two tuber starches. This suggested that addition of AG could retard the short‐term retrogradation of starch. AG also significantly reduced the gel firmness, retrogradation ratio, and relative crystallinity of the two tuber starch gels during storage, indicating that the long‐term retrogradation was retarded with the addition of AG. Meanwhile, the retrograded starch with or without the addition of AG showed B‐type crystallinity pattern. Although PS contains phosphate groups, AG exerted a similar effect on the retrogradation of PS and SPS.ConclusionsResults suggest that the addition of AG could retard the retrogradation and delay the gelatinization process of the two tuber starches.Significance and noveltyThis result can provide available information about the interactions between negative polysaccharide and negative/neutral starch, which also can provide an effective method to retard the starch retrogradation.
A rare case of rectal perforation from an accidentally swallowed foreign body
Authors: Sposato Luigi Alessandro , Reddy Chinnappa 
Published: March 2018

Key Clinical MessageRectal foreign bodies are not an infrequent presentation and can cause a serious dilemma regarding extraction and management. Management is determined by the site of the injury, degree of fecal contamination, the hemodynamic status of the patient, and comorbidities. Intraperitoneal injuries require surgery in the form of either a primary repair or formal resection with or without diversion. Extraperitoneal perforations maybe managed with presacral drainage and antibiotics with or without diversion.
A typical atypical chronic myeloid leukemia
Authors: Gilioli Andrea , Paolini Ambra , Bonacorsi Goretta , Luppi Mario 
Published: March 2018

Key Clinical MessageIn the context of leukocytosis due to increased number of neutrophils and their precursors, with significant dysgranulopoiesis and no or minimal basophilia and no or minimal monocytosis, the typical feature of “clumped” chromatin, in irregularly coarse compacted nuclei, should lead to suspect the diagnosis of atypical chronic myeloid leukemia.
Frequent falls and confusion: recurrent hypoglycemia in a patient with tuberous sclerosis complex
Authors: Comninos Alexander N. , Yang Lisa , Abbara Ali , Dhillo Waljit S. , Bassett J.H. Duncan , Todd Jeannie F. 
Published: March 2018

Key Clinical MessageRecurrent hypoglycemia is common, but its presentation is often insidious resulting in delays in diagnosis and significant morbidity. We describe a case of an insulinoma presenting with falls and confusion in a patient with tuberous sclerosis, demonstrating the importance of early hypoglycemia identification and a potential shared molecular pathogenesis.
Bilateral fibular hemimelia associated with hip dislocation and femoral head necrosis
Authors: Saghir Salahiddine , Bousbaa Hicham , Agadr Aomar 
Published: March 2018

Key Clinical MessageWe describe a case of association of congenital bone abnormalities. It will allow clinicians to look systematically for other skeletal malformations and teach them how to evaluate these cases for the first time. This early screening will enable appropriate treatment to avoid complications and to preserve functional prognosis.
Metastatic renal cell carcinoma presenting with melena
Authors: Sadhale Ashwini , Adike Abimbola , Lam‐Himlin Dora 
Published: March 2018

Key Clinical MessageRenal cell carcinoma is a highly malignant neoplasm. Metastasis to the pancreas and gastrointestinal tract is rare. In this case report, we show images of metastatic renal cell carcinoma to the upper gastrointestinal tract in a patient who presented with melena.
Multiple Metal (Cu, Mn, Fe) Centered Species Simultaneously Combined Nitrogen‐doped Graphene as an Electrocatalyst for Oxygen Reduction in Alkaline and Neutral Solutions
Authors: Lu Lei , Fan Jiawei , Lei Wu , Ouyang Yu , Yao Di , Xia Xifeng , Hao Qingli 
Published: March 2018

AbstractA new efficient composite catalyst (CuIMnFeIIIO/NG) for oxygen reduction reaction (ORR) in both alkaline and neutral media, is successfully prepared via a facile, clean, low‐cost and reproducible solvothermal method without any further treatments. The nanoparticles consisting of crystalline phases of Fe2O3, MnCO3 and amorphous Cu2O&MnxOy (CuIMnO), are anchored on nitrogen‐doping graphene (N/C atomic ratio up to 10.56 %), which offer various active sites toward ORR. The synergistic catalytic effect between these components affords excellent ORR performance with comparable onset potential and current density to commercial Pt/C in both pH‐situations, and a 4‐electron‐transfer path during oxygen reduction. Furthermore, comparative experiment results are discussed to describe the different degrees of ORR contribution in different medium from metal species and nitrogen doping. Meanwhile, superior methanol tolerance and high stability of CuIMnFeIIIO/NG can make it a promising alternative for expensive commercial Pt‐based electrocatalysts in corresponding alkaline and neutral fuel cells.
Graphitic Carbon‐NiCo Nanostructures as Efficient Non‐Precious‐Metal Electrocatalysts for the Oxygen Reduction Reaction
Authors: Sivanantham Arumugam , Shanmugam Sangaraju 
Published: March 2018

AbstractComposites of graphitic carbon layers and transition metals or metal alloys have received considerable attention for use as non‐precious‐metal catalysts for ecofriendly energy devices. In this paper, we report graphitic carbon‐supported NiCo alloys (NiCo@GC) that function as non‐precious‐metal electrocatalysts for the oxygen reduction reaction under alkaline conditions. In particular, we examined the effect of the pyrolysis temperature on the oxygen reduction activity. The catalyst prepared at 600 °C provided an oxygen reduction half‐wave potential (E1/2) of 0.81 V – only 10 mV less than that of a commercial Pt/C catalyst (0.82 V) – with the transfer of almost four electrons. Structural and chemical studies indicated that the excellent activity and stability of the NiCo@GC catalysts resulted from the strong interactions between (and the combined effects of) the metal and the carbon, dictated by the annealing temperature.
Impact of Textural Properties of Mesoporous Porphyrinic Carbon Electrocatalysts on Oxygen Reduction Reaction Activity
Authors: Woo Jinwoo , Sa Young Jin , Kim Jae Hyung , Lee Hyun‐Wook , Pak Chanho , Joo Sang Hoon 
Published: March 2018

AbstractTransition‐metal‐ and N‐codoped carbon (M−N/C) catalysts have shown great promise as alternatives to Pt‐based catalysts in the oxygen reduction reaction (ORR). The preparation of M−N/C catalysts by exploiting mesoporous silica templates is highly appealing as this method can generate catalysts with high surface areas, well‐developed porosities, and abundant active sites. Herein, we report the relationship between the textural properties of mesoporous silica‐templated Fe−N/C catalysts and their ORR activity. Iron‐doped mesoporous porphyrinic carbons (Fe−MPCs) with varying textural properties were synthesized through nanocasting using mesoporous silicas as the templates and Fe porphyrin as the precursor. Fe−MPC catalysts showed excellent ORR activities with half‐wave potentials reaching 0.82 V and 0.90 V (vs. reversible hydrogen electrode, RHE) in acidic and alkaline electrolytes, respectively. Fe−MPC catalysts with smaller particle sizes, larger mesopore sizes, and three dimensionally interconnected pore structures showed enhanced ORR activities.