bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mineralocorticoid hypertension and hypokalaemia induced by posaconazole
Authors: Boughton Charlotte , Taylor David , Ghataore Lea , Taylor Norman , Whitelaw Benjamin C 
Published: February 2018

Summary
We describe severe hypokalaemia and hypertension due to a mineralocorticoid effect in a patient with myelodysplastic syndrome taking posaconazole as antifungal prophylaxis. Two distinct mechanisms due to posaconazole are identified: inhibition of 11β hydroxylase leading to the accumulation of the mineralocorticoid hormone 11-deoxycorticosterone (DOC) and secondly, inhibition of 11β hydroxysteroid dehydrogenase type 2 (11βHSD2), as demonstrated by an elevated serum cortisol-to-cortisone ratio. The effects were ameliorated by spironolactone. We also suggest that posaconazole may cause cortisol insufficiency. Patients taking posaconazole should therefore be monitored for hypokalaemia, hypertension and symptoms of hypocortisolaemia, at the onset of treatment and on a monthly basis. Treatment with mineralocorticoid antagonists (spironolactone or eplerenone), supplementation of glucocorticoids (e.g. hydrocortisone) or dose reduction or cessation of posaconazole should all be considered as management strategies.

Learning points:

Combined hypertension and hypokalaemia are suggestive of mineralocorticoid excess; further investigation is appropriate.

If serum aldosterone is suppressed, then further investigation to assess for an alternative mineralocorticoid is appropriate, potentially using urine steroid profiling and/or serum steroid panelling.

Posaconazole can cause both hypokalaemia and hypertension, and we propose that this is due to two mechanisms – both 11β hydroxylase inhibition and 11β HSD2 inhibition.

Posaconazole treatment may lead to cortisol insufficiency, which may require treatment; however, in this clinical case, the effect was mild.

First-line treatment of this presentation would likely be use of a mineralocorticoid antagonist.

Patients taking posaconazole should be monitored for hypertension and hypokalaemia on initiation and monthly thereafter.
INVESTIGATING ENGLISH LANGUAGE TEACHERS IN DEVELOPING TPACK AND MULTIMODAL LITERACY
Authors: Drajati Nur Arifah , Tan Lynde , Haryati Sri , Rochsantiningsih Dewi , Zainnuri Hasan 
Published: February 2018

Technology in every field is snowballing. Likewise, the use of technology in education requires knowledge and understanding of English teachers. The fact that most of the technology for enhanced language learning workshop did not continue into the classrooms. Another case is that teachers do not want to use technology at all in their classrooms because of lacking time and facilities. TPACK namely Technological Pedagogical Content Knowledge provides insight for pre-service teachers and in-service teachers of English to optimize three things for education; those are the aspect of technology, pedagogy, and content knowledge. With the use of this learning model, excellent technology, pedagogy, and knowledge will support and produce a comprehensive learning process. The purpose of this study was to examine the perception and implementation of pre-service teachers and in-service teachers about the literacy of the three above aspects. By using qualitative research, we get the data from questionnaires of 100 pre-service teachers and in-service teachers. The findings describe the demographic teacher with technology, pedagogy and content knowledge literacy (TPACK). The three points of the TPACK literacy are Pedagogical Content Knowledge for Multimodal Literacy, Technological Pedagogical Knowledge (21st C Learning), and Knowledge about digital media tools. The implications of this research give direction and the alternatives to the implementation of the TPACK model for English classroom. In future, it provides the advantages to developing the quality of English teachers’ professional development. Keywords:
CORRELATING WRITER’S BLOCK AND ESL LEARNERS’ WRITING QUALITY
Authors: Dela Rosa John Paul O. , Genuino Cecilia F. 
Published: February 2018

Despite the importance of writing in the language learners’ development, there are difficulties faced by English as a Second Language (ESL) learners that stem from various factors. One of them is the presence of writer’s block that could affect writing quality. Therefore, this study aims to describe writer’s block, along with a statistically-laden analysis of the possible correlation between the blocking experiences of 55 Filipino ESL learners and the levels of easability and readability of the essays they had written. This research employed a descriptive-correlational design using The Questionnaire in Identifying Writer’s Block (QIWB) to gauge the extent of occurrence of writer’s block and the Coh-Metrix Common Core Text Easability and Readability Assessor (hereafter Coh-Metrix T.E.R.A.), an online computational tool, to measure the levels of easability and readability of the essays. The result shows that the learners generally experienced writer’s block, and their essays collectively showed high levels of easability on the basis of narrativity, referential cohesion, and deep cohesion. However, the essays were low in syntactic simplicity and word concreteness, while the level of readability computed exceeded that of the reading ability of 10th-grade learners. Test of correlation revealed that there exists negligible relationship between writer’s block and the overall easability and readability levels of the essays, though a significant but a weak relationship was documented between lateness and word concreteness and with premature editing and deep cohesion, respectively.
COMMUNICATION PATTERNS AMONG KIAIS OF NAHDLATUL ULAMA IN THE MADURESE ETHNIC GROUP
Authors: Haryono Akhmad 
Published: February 2018

Research on communication patterns with an ethnographic approach has been conducted by many linguists, but apparently there has hardly been any research on communication patterns within an NU society with its strong paternalistic cultural background. In fact, the uniqueness of this culture also has had a major influence on NU members’ communication patterns in their daily interaction. This study aims to describe the communication patterns among kiais (venerated teachers of Islam) of Nahdlatul Ulama in the Madurese ethnic group (NUME) and account for the factors affecting those patterns of communication. A qualitative method with an ethnographic approach was applied to achieve this research’s objectives. The data were collected through participatory and non-participatory observations, interviews, note-taking, and recording. The recorded data were transcribed and analyzed descriptively using the components of speech analysis, conversational analysis, discourse analysis with pragmatic concepts, and explanation. This study found that giving an honor to the teacher in the NU tradition is an obligation and a tradition that is still maintained. This phenomenon is reflected in the patterns of communication among kiais that have teacher-student ties (KT-KS). The patterns of communication among kiais bearing teacher-students ties (KT-KS) are influenced by situational factors, i.e. formal and informal situations. In an informal situation the KT-KS patterns of communication are influenced by age differences. The age differences that affect the gaps of KT-KS patterns of communication both in formal and informal situations only find expression in the use of speech levels, while in terms of patterns of language selection, tones of voice, body language, and turn-taking, the differences were not found.
H5N1 influenza vaccine quality is affected by hemagglutinin conformational stability
Authors: Sergeeva Mariia , Krokhin Artem , Matrosovich Mikhail , Matrosovich Tatyana , Wolschek Markus , Kiselev Oleg , Romanova Julia 
Published: February 2018

ABSTRACT
Since 1997, highly pathogenic H5N1 avian influenza viruses have circulated in wild and domestic birds and sporadically have infected humans. Conventional inactivated vaccines made from these viruses were shown to have decreased HA content and immunogenicity compared to seasonal preparations. We assumed that the high pH threshold (5.6-6.0) known for the HA conformational change (pH of fusion or activation) of avian highly pathogenic influenza viruses was the reason of the low stability of native HA conformation and affected the vaccine quality. The 58Lys→Ile mutation introduced into the HA2 subunit of the HA of A/chicken/Kurgan/5/05 (H5N1) virus decreased the pH threshold of the HA activation. The mutant virus demonstrated increased HA stability toward acidic pH and elevated temperature, decreased binding efficiency to the monoclonal antibody IIF4 that recognizes the HA low pH form, and increased HA resistance to trypsin digestion. Virus with modified HA was less susceptible to freezing stress and showed an increased content of immunocompetent HA in inactivated vaccine preparation compared to the analogous virus with original HA. Therefore, we have shown a way to increase the quality of inactivated vaccines made from highly pathogenic avian influenza viruses.
Development of the cell-ELISA test for the subtype identification of circulating influenza A(H1) and A(H3) viruses
Authors: Krivitskaya Vera , Sorokin Evgeniy , Tsareva Tatyana , Petrova Ekaterina , Konovalova Nadezhda , Pisareva Maria , Buzitskaya Zhanna , Smirnova Tatyana , Sominina Anna 
Published: February 2018

ABSTRACT
The sensitive version of cell-ELISA was developed for the subtype-specific differentiation of current influenza A(H1N1)pdm09 and A(H3N2) viruses that are circulating in the human population. This method is based on the estimation of virus reproduction in infected MDCK cells. The detection step of this method is an interaction of the subtype-specific monoclonal antibodies (mAbs) with the viral hemagglutinin (НA) molecule. The influenza A virus strains, isolated in the 2014 epidemic season, were used to validate this method.
It was shown that when using mAbs # 1/ # 2 or # 4 at a concentration of 10-15 μg/ml, the developed variant of cell-ELISA was able to detect НA protein synthesized in the infected cells of influenza A(H3N2) and A(H1N1)pdm09 viruses, respectively.
The developed method can be used for the identification of modern influenza A viruses with low hemagglutination activity, which is not possible by the conventional hemagglutination inhibition test.
Influence of single amino acid substitutions in the hemagglutinin on the antigenic and receptor-binding properties of influenza virus B/Florida/04/2006 of Yamagata-like evolutionary lineage
Authors: Sorokin Evgeniy V. , Tsareva Tatyana R. , Sominina Anna A. , Pisareva Maria M. , Komissarov Andrey B. , Kosheleva Anna A. 
Published: February 2018

ABSTRACT
Influenza A and B viruses use sialylated oligosaccharide chains expressed on the surface of a host cell as the cell entry receptors. The type of the bond between sialic acid (SA) and the neighboring galactose residue (Gal) is one of the main characteristics that define the type of receptor. Influenza viruses recognize SAα2-3Gal- or SAα2-6Gal-structures on the surface of the cells. Influenza A viruses of avian origin bind α2-3-sialylated glycans, while the human strains bind preferentially α2-6-sialylated ones. However, the receptor-binding specificity of influenza B viruses has not been characterized sufficiently so far. In this study, we selected the escape mutants of influenza B/Florida/04/2006 strain (Yamagata-like lineage) using monoclonal antibodies (mAb) to hemagglutinin (HA). The analysis of the amino acid sequences of mAb-induced escape mutants revealed the single amino acid substitutions 40Tyr→His, 85His→Tyr, 202Asn→Lys and 242Ser→Arg in 10F4-, 8Н11-, 8Н3- and 9A3-induced HA variants, correspondingly. It was shown that the single amino acid substitutions 202Asn→Lys and 242Ser→Arg alter the receptor-binding specificity of the influenza B virus. These findings are important for the understanding of the influence of individual amino acid residues in HA on the receptor-binding properties of influenza B Yamagata-like lineage viruses and allow us to predict the possible ways of their evolution.
A new safe and effective cold-adapted modified live equine influenza virus vaccine that enables the differentiation of infected from vaccinated animals
Authors: Tabynov Kaissar 
Published: February 2018

ABSTRACT
An analysis of the main advantages and shortcomings of the existing inactivated and live vaccines against the equine influenza viruses (EIVs) is given in this paper. For the first time, the most important information, concerning the development of a new live modified cold-adapted (ca) equine influenza virus vaccine based on the A/HK/Otar/6:2/2010 strain is summarized. We discuss a number of unique features of the developed vaccine that have not previously been reported, and compare the new vaccine with the existing equine influenza vaccines. The properties of the developed equine vaccine include: long-lasting (12 months or more) protective immunity after a single immunization; sterile immunity after double vaccination; cross-protection against the heterologous virus at 12 months after double vaccination and the differentiation of infected from vaccinated animals.
Assessment of air pollution effects in the subjects of Khartoum industrial area, Sudan via cytological interpretations
Authors: Osman EM 
Published: February 2018

The study was conducted to assess the air pollution-related lung cellular proliferative activity and inflammatory cells infiltrate among Sudanese subjects, who worked at least 8 hours per day. A total of seventy-five workers who worked for at least 5 years in the polluted area were included, sputum/ blood samples were collected to evaluate the cytological atypia and metaplasia.Out of 75 subjects, Cytological atypia and metaplasia were detected among 8% and 16% of the participant respectively, and such types of changes due to the exposure of occupational air pollution were found to be statistically significant (P= 0.01 ). Similarly, acute and chronic inflammatory cells infiltrate were identified among 10.7% and 14.7% of the study subject respectively; the changes was statistically significant compared to control (P= 0.001). Exposure to occupational air pollutant was associated with alteration in cells of lungs such atypia, acute and chronic inflammatory cells. This finding supports the earlier studies that long exposure to air pollutants is associated to lung atypical alterations.
Keywords: Lung epithelial, air pollution hazards, Sudan
The Importance of Family Centered Care and Assessment
Authors: Aykanat Girgin Burcu 
Published: February 2018

Abstract
Development and protection of children's health is important for the promotion and protection of public health. Primary responsibility for the development and protection of public health isin the family then the health care team members and the social environment. Hospitalization of a child is a stressful process both for the child and the family. In the literature, requirements of families are reported about staying with their children at hospital during hospitalization, taking active role in caring for their children and being informed for the health condition of the child, diagnosis and treatment tests. Therefore, family centered care is suggested for accelerating child’s recovery process with decreased child’s and families anxiety and providing the most convenient health service for expectations and needs of families in the hospital environment. Family centered care philosophy is based on recognition of the family’s central role in the child’s life and providing active participation of the family for health related decisions about their children. To effectively practice family centered care, nurses must be clear and consistent in their understanding and practices about the care of children and their families. Child Health Nurses need valid and reliable measurement tools to show their perceptions and practices regarding family centered care. In the literature, Family Centered Care Questionnaire, Family Centered Care Survey and Measure of Processes of Care for Service Providers were found to assess family centered care applications. However, the studies showing status of family centered care model in our country and studies introduce this measurement tools are very limited. Introduction and use of this measurement tools is very important for the quality of care given by nurses.
Keywords: family centered care, child health nurses, assessment.
Effect of job and individual factors on Work Ability Index (WAI) in a dairy company
Authors: Kalte Haji Omid 
Published: February 2018

Abstract
Background: The work ability index (WAI) is one the most widely used instruments for measuring perceived work ability. However, very few studies have used this instrument in Iran. The present study is designed to assess effect of individual and work-related risk factors on the WAI in one dairy factory. Methods: This cross-sectional study was designed among 117 workers. Work ability was measured by the Persian versions of Work Ability Index (P-WAI). An author-developed measure was used to assess individual and work-related factors. All Statistical analyses were performed using IBM SPSS Statistics 21 (USA, SPSS Inc.). Results: The mean age of participants was 32.38 ± 7.3 and the Mean score of the WAI was 44.92 ± 5.56. According to the categorical classification of WAI score, 10.9, 35.6, and 53.5 % of participants had moderate, good and excellent work ability, respectively. The results of statistical analyses showed that mean WAI significantly differed with age (0.049), sleep quality (p= 0.035) and employment status (p= 0.014). Conclusion: To improve the workers’ work ability, intervention programs should focus on improving sleep quality and exercise. Also, we suggest that increasing job insecurity should be considered an important intervention in promoting worker’s work ability.
Keywords: Work Ability Index (WAI), Sleep Quality, Job Insecurity
Identifying Ergonomic Risk Factors in Bank
Authors: Ozvurmaz Safiye 
Published: February 2018

Abstract
Working without changing posture for a long period, repetitive body motions and non-ergonomic work conditions can lead various health problems in bank employees. In this study, the objective is to investigate the ergonomic risk factors of bank employees who work with computers. The study involves 221 bank employees who work with computers. Data were collected using self-assessment surveys which were completed between July-September 2013. The survey includes socio-demographic and work related questions. Ergonomic risk points were assessed using a 6-level Likert scale which inquires constant standing, constant sitting and repetitive motions. Higher ergonomic risk scores indicate poor/inconvenient working conditions. Ergonomic risk point was calculated between 4 as minimum and 24 as maximum. Statistical analysis was performed by chi-square test, student t-test and logistic regression analysis. Demographics of the participants are as follows: 46.6% aged between 30-39 years, 56.1% male, %91.1 university-graduate, 65.6% married, 48.8% have kids. 19.9% of participants do sports, 83.7% right-handed, 6.8% has attended training about ergonomics, 8.1% constantly stand, 40.3% constantly sit, 33.9% do repetitive motions and 5.4% movements which are drastic for the body. 51.1% of the participants described their office chairs to have a medium comfort level and 4.5% reported their office table to have a very good comfort level. Mean ergonomic risk level point is calculated as 13.8±2.8, weekly total computer use time was calculated as 44.6±10.4 and mean comfort perception point for work environment is calculated as 18.9±4.3. It is determined that ergonomic risk factors are common in bank employees working with computers.
Keywords: Ergonomics, risk factor, bank employee, computer Workstation
Green Leaf Grocery - Executive Compensation Case Study
Authors: Cox Marcus Z. , Crocker Robert Mitchell 
Published: February 2018

The primary purpose of this teaching case is to aid students in understanding how executive compensation plans are utilized to achieve organizational goals and to then construct their own executive compensation plan for the CEO of Greenleaf Grocery, a fictional retail business based on an actual company.
Students have the opportunity to create a comprehensive executive compensation plan using salary, bonuses, stock options, benefits, and other compensation tools. Additionally, the case provides the opportunity to discuss the use of both short-term and long-term incentive compensation. The company in this case is poised to undertake an initial public offering of stock and retaining the current CEO is viewed as critical for this next phase.
The case affords the class the opportunity to explore ethical issues in executive compensation as well as other aspects of the organization’s overall compensation structure.
Evaluation of Cover Crops Drill Interseeded into Corn Across the Mid‐Atlantic Region
Authors: Curran W.S. , Hoover R.J. , Mirsky S.B. , Roth G.W. , Ryan M.R. , Ackroyd V.J. , Wallace J. M. , Dempsey M.A. , Pelzer C.J. 
Published: February 2018

Core Ideas
Cover crops were successfully established in corn with a drill interseeder.Cover crop biomass production varied notably across the mid‐Atlantic region.Spring cover crop biomass was often proportional to fall cover crop performance.Interseeding cover crops at corn growth stages V2–V3 decreased corn grain yields.Interseeding cover crops at or after corn V4 did not affect corn grain yield.
Cover crop adoption remains low in the mid‐Atlantic United States despite potential conservation and production benefits. The short growing season window after corn (Zea mays L.) is a primary limiting factor. A high‐clearance grain drill was recently developed to allow for cover crop interseeding into standing cash crops. Experiment 1 tested the viability of drill interseeding cover crops into corn at the V5 growth stage across multiple locations. Experiment 2 tested interseeding timing (V2–V6 corn growth stage) on corn yield in Pennsylvania. At 16 locations throughout Maryland, Pennsylvania, and New York, we evaluated cover crop fall and spring biomass and the effect on corn yield. Cover crop treatments included annual ryegrass [Lolium perenne L. ssp. multiflorum (Lam.) Husnot]), a mixture of legume species, and an annual ryegrass–legume mixture. Each cover crop treatment successfully established across locations yet was highly variable. Across locations, annual ryegrass–legume mixture produced the highest mean aboveground biomass in fall and spring. Spring biomass of interseeded cover crops generally increased compared with fall biomass. Interseeded cover crops did not affect grain yields of the host corn crop during the year of establishment across locations. Experiment 2 indicated that cover crops interseeded before the V3 growth stage reduced corn grain yields. We recommend interseeding at or after V4 to prevent competition with corn. Our results highlight the viability of drill‐interseeding as a strategy for increasing cover crop adoption.