bluuebunny/crossref_metadata_2025_split huggingface dataset:
Squamous cell carcinoma of tympano-mastoid region: a series of six cases
Authors: Kumar Surender , Garg Uma , Sharma Naveen , Salaria Neha , Verma Deepak 
Published: April 2018

<p class="abstract">The malignancies of tympanomastoid region are very rare entity. These tumours are more common in elderly persons in 6th and 7th decade. Males are more commonly affected than females. Chronically discharging ears are considered as risk factor which may be due to metaplasia in the middle ear mucosa following prolonged chronic infection. The most common symptoms are long standing blood tinged ear discharge, severe nocturnal pain, rapidly growing polypoidal or granulomatous mass in EAC or middle ear, peripheral facial palsy and painless ulceration over pinna or EAC. CT scan for bony erosion and MRI for soft tissue involvement and neural invasion are investigations of choice. Tissue biopsy is must for histopathological examination and confirmation of diagnosis. Surgery and chemo-radiotherapy are the mainstay of treatment. Surgery includes wide local excision, lateral temporal bone resection, subtotal temporal bone resection and total temporal bone resection.</p><p class="abstract"> </p>
The Smartphone Use in Indonesian Schools: The High School Students’ Perspectives
Authors: Machmud Karmila 
Published: April 2018

<p> </p><p>The goal of this research is to investigate schools’ policy of using a mobile phone at schools from the perspective of secondary school students in Indonesia. It happens to be a long debate involving educators in Indonesia on whether or not the use of smartphone can be allowed in schools. So far, all we hear is the perspectives of teachers and schools’ administrators regarding the ban but never from the students, even though the students are the subject of these debates. This research is conducted in order to investigate, as well as to give the opportunity for students’ to voice their opinion, point of views, and perspectives toward the issue of banning smartphone use at schools. The data of this research was collected through online survey aimed at secondary schools’ students in Gorontalo, Indonesia. There are 250 students from 5 high schools have responded to the online surveys. The result shows that even though students mostly believe that the use of smartphone should be integrated into teaching and learning process, an appropriate policy of using it at school should be designed in order to get rid of the negative impact cause by it, and to maximize the use of it as a sophisticated resource to help students learn better at school.</p>
Design, Implementation and Evaluation of a Learning Object that Supports the Mathematics Learning in Children with Autism Spectrum Disorders
Authors: Munoz Roberto , Becerra Carlos , Noël René , Camblor Matías , Barcelos Thiago S. , Kreisel Sandra , Villarroel Rodolfo 
Published: April 2018

Information technologies have been widely used for entertainment and learning purposes by children with Autism Spectrum Disorders (ASD). Nonetheless, learning objects aiming at specific skills development in children with ASD require both a well bounded learning domain and a user-centered design process, considering skill levels of the users and the local geographical context and language.
“Proyect@ Matemáticas” is a multi-touch based app designed for developing pre-calculus and functional mathematical skills in children with ASD, according to the Chilean regulations of learning goals for children with special educational necessities. This paper presents the User-centered design process conducted in order to develop the learning object, which included the evaluation by 15 experts in special educational needs, testing by 10 ASD-diagnosed children with different functional levels, and a multidisciplinary development team that also included a graphic designer diagnosed with ASD of high functionality.
The development process yields to a validated learning object in terms of interactivity, design, engagement, and usability, from the point of view of the experts, and successful usage tests with ASD diagnosed children in terms of performance and achievement of learning outcomes. The application is currently available for download in the Google Play store for free, and currently has more than 15,000 downloads and an average rating of 4.2 out of 5 points.
Phosphorus Sorption Characteristics in Aluminum‐based Water Treatment Residuals Reacted with Dairy Wastewater: 1. Isotherms, XRD, and SEM‐EDS Analysis
Authors: Zohar Iris , Massey Michael S. , Ippolito James A. , Litaor M. Iggy 
Published: April 2018

We examined P sorption characteristics in Al‐based water treatment residuals (Al‐WTR) generated from slightly alkaline surface water and in an organic residual composite (WW‐Al/O‐WTR), produced by using the Al‐WTR to treat organic‐rich and high P concentration dairy wastewater. Solids from both residuals were examined using scanning electron microscopy–energy dispersive spectroscopy (SEM‐EDS) and X‐ray diffraction (XRD), and exposed to P additions of 0 to 4000 mg L−1 in a sorption experiment. The Al‐WTR removed ∼97% of the added P, whereas WW‐Al/O‐WTR removed only 78% of the added P in the addition range of 0 to 100 mg P L−1. With P additions of ≥100 mg L−1, the removal rate declined to <38% by Al‐WTR and to 16% by WW‐Al/O‐WTR, possibly implying a change in sorption mechanisms. Analysis by XRD indicated that the major mineral was calcite, with some silica and poorly crystalline Al hydroxides. Analysis by SEM‐EDS, which used three‐element overlay maps of the residual surfaces, indicated that P was sparsely sorbed on both calcic and Al (hydr)oxide surfaces, along with a few clusters, even at low P concentrations of the treated waters. Ternary clusters of P, Al, and Ca were more abundant on the WW‐Al/O‐WTR. Carbon distribution suggested that organic substances covered Al surfaces. Sorption of P onto WW‐Al/O‐WTR may be reversible due to relatively weak Ca‐P and Al‐P bonds induced by the slight alkaline nature and in the presence of organic moieties, enhancing the WW‐Al/O‐WTR potential to act as a P source, rather than a P sink, in agricultural applications.Core Ideas
Water treatment residuals displayed two distinct regions in sorption isotherms.
Variable P associations and distribution were elucidated by advanced SEM‐EDS mapping.
Mixing with wastewater promoted Al‐P, Ca‐P, and Al‐Ca‐P associations closer together.
The presence of organic C and slight alkaline nature may enhance P release.
Evidence from P K‐edge XANES complemented these findings (see Part II).
COLOR NAMES "WHITE" AND "BLACK" IN DESCRIPTIONS OF PERSON IN THE KAZAKH LANGUAGE VS. ENGLISH AND RUSSIAN
Authors: Abzhaparova M. D. 
Published: April 2018

This article is dedicated to the problem of color perception in the language worldview in describing a person according to the «black and white» color palette in Kazakh, English and Russian; it also examines phraseological units that feature these colors. Color is one of the principles of culture; many cultural phenomena cannot be understood without taking into account the importance of color. In particular, in descriptions of person one can distinguish a number of general associative color fields with similarities and differences. A study of phraseological dictionaries of the Kazakh, English and Russian languages, as well as works of fiction, has revealed that the color designation "ақ-белый-white" and "қара-черный-black" differ in their versatility in describing one’s appearance, character and social status. Subject: color perception in the language worldview of Russian, Kazakh and English speakers. The purpose of the work: to identify common and differential manifestations of white and black in different linguocultures using lexemes "ақ – белый – white" and "қара – черный – black" in phraseological units. Method of investigation: semantic and communicative analysis. In Kazakh, Russian, and English, white and black colors in description of person have a wide scope of application. Their frequency means that these color codes are part of a group of tokens with a high potential for phraseological activity. These colors are actively used both in everyday life and fiction when a person is described with the help of color contrasts. Material of the research: the paper features phraseological units with the elements of color identification "white", "black" and "red" from verbal folklore and Kazakh literature classics, as well as works by Russian and English writers.
Alternative water sources in New Zealand's commercial buildings
Authors: Bint L. , Garnett A. , Siggins A. , Jaques R. 
Published: April 2018

Abstract
Rainwater harvesting and greywater recycling are two potential measures to make significant reductions in commercial building water use in New Zealand. Rainwater harvesting involves the collection of water from roofs during rainfall events, while greywater recycling is the reuse of water from hand basins and showers for use in toilets and urinals. The feasibility of these systems was investigated via three areas of focus: drivers and barriers; system operation; savings to the water network. Initial results show volumetric wastewater tariffs are primary drivers for water efficiency and conservation. However, a lack of consistent regulation, perceived risks of water quality issues and loss of space for storage are perceived as barriers. Case-study buildings showed that, in locations where both water and wastewater are charged volumetrically, the relative benefit–cost comparisons were judged as acceptable by building management. Where only water is charged volumetrically (with wastewater based on annual rating valuations), this was less favourable. Water quality tests showed only minimal imperfections. Concerns appear to be largely an issue of perceived risk rather than actual risk. Together with site visits, the water quality testing has contextualised valuable feasibility, design and operational opportunities. The savings to the water networks, however, appear to be minimal.
The San Remo conference and the Armenian question (April of 1920)
Authors: Nazaryan Gevork Pargev 
Published: April 2018

Present article presents the Armenian Question during the Conference of San Remo (April of 1920). The Allied Supreme Council discussed the question of a mandate for Armenia and the delimitation of its boundary. The Supreme Council pledged to support Armenia politically, military and financially. The Allied leaders agreed that the Armenian provinces of Erzerum, Van, Bitlis, as well as Trebizond (which would ensure access to the Black Sea) were integral parts of Armenia. The Supreme Council requested, after the consent of Armenian and Turkish sides, U.S. President Woodrow Wilson, as a neutral party, to delimit the boundary between Armenia and Turkey. President Wilson agreed and in accordance with international law made the Arbitrary Award (November 22, 1920), which established the legal state boundary between Armenia and Turkey.
Pharmakon Bağlamında Dil Felsefesi
Authors: Bingöl Mustafa 
Published: April 2018

İnsanın olduğu yerde “dil”
de vardır çünkü o diliyle beraberdir. Dilin insanla bağlantılı hali onu
vazgeçilmez kılmıştır. Bu vazgeçilmezlik ise onun kullanılmasına neden
olmuştur. Giriş kısmında dilin kavramsal analizi yapılarak,
Platon’un felsefesine etki eden, Herakleitos ve Parmenides’in görüşleri irdelendi.
Birinci başlıkta diyalog ve diyalektik arasındaki ilişkinin önemi üzerinde
durularak retorik kavramına geçiş yapıldı. İkinci başlıkta ise Platon’un
yazının ve çarenin tanrısı olarak gördüğü
pharmakon kavramının dil felsefesindeki yeri ve önemi üzerinde duruldu.

Sonuç kısmında ise pharmakon gibi güçlü bir kuvvetin
Sofistlerin eline bırakılmaması ifade edilir ve bu kuvvetin uzmanların elinde
soylu bir yalana dönüşmesine izin verilebilir.
Structure-Based Virtual Screening and Biochemical Evaluation for the Identification of Novel Trypanosoma brucei Aldolase Inhibitors
Authors: Ferreira Leonardo L.G. , Ferreira Rafaela S. , Palomino David L. , Andricopulo Adriano D. 
Published: April 2018

Introduction: The glycolytic enzyme fructose-1,6-bisphosphate aldolase is a validated molecular
target in human African trypanosomiasis (HAT) drug discovery, a neglected tropical disease
(NTD) caused by the protozoan Trypanosoma brucei. Herein, a structure-based virtual screening
(SBVS) approach to the identification of novel T. brucei aldolase inhibitors is described. Distinct molecular
docking algorithms were used to screen more than 500,000 compounds against the X-ray structure
of the enzyme. This SBVS strategy led to the selection of a series of molecules which were evaluated
for their activity on recombinant T. brucei aldolase. The effort led to the discovery of structurally
new ligands able to inhibit the catalytic activity of the enzyme.

Results:
The predicted binding conformations were additionally investigated in molecular dynamics
simulations, which provided useful insights into the enzyme-inhibitor intermolecular interactions.

Conclusion:
The molecular modeling results along with the enzyme inhibition data generated practical
knowledge to be explored in further structure-based drug design efforts in HAT drug discovery.
A Novel Fluorescence-Based Screen for Inhibitors of the Initiation of DNA Replication in Bacteria
Authors: Klitgaard Rasmus N. , Løbner-Olesen Anders 
Published: April 2018

Background:One of many strategies to overcome antibiotic resistance is the discovery of compounds targeting cellular processes, which have not yet been exploited.Materials and Methods:Using various genetic tools, we constructed a novel high throughput, cellbased, fluorescence screen for inhibitors of chromosome replication initiation in bacteria.Results:The screen was validated by expression of an intra-cellular cyclic peptide interfering with the initiator protein DnaA and by over-expression of the negative initiation regulator SeqA. We also demonstrated that neither tetracycline nor ciprofloxacin triggers a false positive result. Finally, 400 extracts isolated mainly from filamentous actinomycetes were subjected to the screen.Conclusion:We concluded that the presented screen is applicable for identifying putative inhibitors of DNA replication initiation in a high throughput setup.
Design, Synthesis and In vitro Cytotoxicity of New 1,2,3-triazol- and Nitrostyrene Hybrids as Potent Anticancer Agents
Authors: Tashrifi Zahra , Mohammadi-khanaposhtani Maryam , Shafiee Ardestani Mehdi , Safavi Maliheh , Rad-Moghadam Kurosh , Mehrdad Morteza , Larijani Bagher , Mahdavi Mohammad 
Published: April 2018

Background:
A new series of 1,2,3-triazol-nitrostyrene derivatives was designed,
synthesized, and evaluated for cytotoxic activity against Hep-2 and L929 cell lines.
</P><P>
Methods: The synthetic procedure started from the functionalization of 4-hydroxybenzaldehyde
with propargyl bromide and a subsequent click reaction to give 1,2,3-triazole derivatives. Then, the
reaction of the mentioned derivatives with nitromethane led to the formation of the title compounds
in excellent yields.

Results:
Most of the compounds exhibited better cytotoxic activity with respect to the standard drug
5-fluorouracil. Among them, (E)-1-(3,4-dichlorobenzyl)-4-((4-(2-nitrovinyl)phenoxy)methyl)-1H-
1,2,3-triazole 6i (IC50 = 4.66 &#177; 1.3 &#181;M) against the Hep-2 cell line and (E)-1-(2,3-dichlorobenzoyl)-
4-((4-(2-nitrovinyl)phenoxy)methyl)-1H-1,2,3-triazole 6g (IC50 = 5.18 &#177; 0.8 &#181;M) against the L929
cell line exhibited the best cytotoxic effects.

Conclusion:
Moreover, the acridine orange/ethidium bromide double staining technique showed
that the most potent compounds 6i and 6g could induce apoptosis in studied cancer cell lines.
Polymeric Micelles of Modified Chitosan Block Copolymer as Nanocarrier for Delivery of Paclitaxel
Authors: Lather V. , Saini V. , Pandita D. 
Published: April 2018

Background:
Polymeric micelles are being used as successful nanocarriers for
the delivery of diverse drug molecules due to properties like solubilization, selective targeting,
P-glycoprotein inhibition, altered drug internalization route and subcellular localization
etc.

Objective:
The present investigation was planned to prepare and characterize novel polymeric
micelles derived from self assembly of amphiphilic chitosan-bile salt derivative
(CS-mPEG-DA) as nanocarrier and evaluate their potential in delivery of an anticancer
drug, paclitaxel.

Method:

Paclitaxel, a diterpenoid compound, useful in clinical treatment of several solid
tumors such as ovarian cancer, breast cancer and lung cancer suffers from limitations like
low aqueous solubility and bioavailability and subsequently was used as the model drug.

Results:

Paclitaxel was successfully incorporated into polymeric micelles using dialysis
and emulsion method with encapsulation efficiency up to 95% having particle size in
nanometer range (<200 nm). Paclitaxel loaded micelles were found to release the drug in
a sustained manner up to 96 h in PBS containing 0.1% (w/v) tween 80 at 37&#176;C. The micelles
powders subjected to stability studies for a period of 90 days were found to be stable
at 4 &#177; 2&#176;C with respect to particle size and drug content. In vivo cytotoxicity assay
confirmed that paclitaxel encapsulated in polymeric micelles showed higher cytotoxicity
against cultured MCF-7 breast cancer cells than paclitaxel alone.

Conclusion:
Polymeric micellar systems derived from copolymerization of chitosan exhibit
a great potential in successful delivery of poorly water soluble or low bioavailable
drugs like paclitaxel.
A Comparasion Of The Leading Sectors Contibuting To Economic Growth Before And After The Economic Crisis in East Kalimantan: An Econometrical Approach
Authors: Sudarlan S.E. , Rudzali Achmad , Akbar Khairil 
Published: April 2018

East Kalimantan province is not only rich in the natural resources of mining, but also in agriculture. The objective of this research is to know the extent of the contribution of the main sector's like agriculture, mining, industry and trade sectors before and after the occurrence of the economic crisis in East Kalimantan. The results of this study indicate that (a). Almost all of the independent variables used, namely agriculture, mining, industry and trade sectors have insignificant impact on the growth of per capita income before and after the economic crisis, except for an agriculture sector, (b). The agriculture sector has a positive influence and significantly to the growth of per capita income before the economic crisis, but after the economic crisis it was not significant impact on the growth of income per capita.
Percurso Teórico-metodológico do Processo de Autoavaliação de um Curso de Formação Profissional
Authors: Durli Zenilde , Battisti Archer Aline , Eller Gomes Diego , Moraes Cruz Roberto 
Published: April 2018

O objetivo deste relato de experiência é descrever o percurso teórico-metodológico do processo de autoavaliação do curso de Prevenção dos Problemas Relacionados ao Uso de Drogas – Capacitação para Conselheiros e Lideranças Comunitárias, 6a edição, oferecido na modalidade de educação a distância. A finalidade desse processo foi produzir conhecimento acerca dos eixos "planejamento", "execução", "gestão" e "resultados" do Curso. Seu principal produto foi um relatório composto pela descrição dos resultados de cada dimensão de análise e por proposições de aperfeiçoamento do Curso.
Evidência do desânimo de alunos em um ambiente virtual de ensino e aprendizagem: uma proposta a partir da mineração de dados educacionais
Authors: Damando Santos Fabrícia , Bercht Magda , Krug Wives Leandro 
Published: April 2018

O artigo relata uma pesquisa que busca identificar o aluno desanimado, em um ambiente virtual de ensino e aprendizagem utilizando mineração de dados. Foram aplicadas duas técnicas de classificação de dados utilizando árvore decisão, uma através do Holdout e outra com Cross-validation. Os resultados do modelo preditivo mostraram acerto em cerca de 91% dos dados para o método Holdout e 77% para cross-validation. Novos experimentos serão realizados a fim de validar o modelo e desenvolver ações que subsidiem o professor no apoio a esses alunos
Narrativas e fotografias:memórias do tempo vivido na ruína “Casa e Bazar Nazaré de Izidoro Cunha Júnior”, em Santana do Capim-PA
Authors: Borges Adão Souza , Ferraz Maria Das Graças 
Published: April 2018

Este estudo pretende refletir acerca da memória dos moradores e vizinhos de uma ruína denominada Casa Bazar Nazaré de Izidoro Cunha Júnior na vila Santana do Capim, em Aurora do Pará. O trabalho foi desenvolvido com a proposta de realizar um diálogo entre a memória e a antropologia visual, utilizando a fotografia como recurso capaz de proporcionar narrativas que visibilizem o cuidado que os herdeiros do proprietário da ruína têm com os objetos que simbolizam o seu apogeu, quando esta era um estabelecimento comercial de grande influência econômica e social para a população ribeirinha no início da década de 60.Palavras-chave: Antropologia visual. Fotografia. Memória. Narrativa. Ruína. Narratives and photographs: memories of the time lived in ruin “house and bazaar Nazareth” of Izidoro Cunha Jr. in Santana do Capim/PAAbstractThis work aims to reflect on the memories of residents and neighbors of a ruin called Nazaré de Izidoro Cunha Júnior Bazar`s House in the village called Santana do Capim located in Aurora do Pará, Para State. It was developed with the proposal to hold a dialogue between memory and visual anthropology, using photography as a resource capable of providing narratives, which the heirs of the owner of the ruin, help to understand how they care of those objects. These also symbolize the pinnacle of ruin, when this was a business of great economic and social influence over the local population at the beginning the 60.Key words: Visual anthropology. Fotograph. Memory. Narratives. Ruin.