bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural: A $75 billion word with no definition—Why not?
Authors: Chambers Edgar , Tran Thao , Chambers Edgar 
Published: April 2019

AbstractNatural is a $75 billion word with no official definition in most countries. The United States Food and Drug Administration has given only an unclear guideline on what constitutes natural instead of an actual definition. Sensory and other scientists need to understand the motivations and attitudes of consumers about the products they use. “Natural” is a commonly used term on labels and advertising for food and other products. This research examined 30 ingredients used in food products to determine which ingredients consumers considered natural and why they consider certain ingredients as “not natural.” A national U.S. survey of 1,051 consumers (primary food purchases: 43% male, 57% female) was analyzed using descriptive statistics and chi‐squared tests. No ingredient, except for sea salt, was found to be natural by more than 70% of respondents. Familiarity with an ingredient was instrumental in consumers' determination of naturalness. Healthfulness and chemical sounding names also played a role in whether a product or ingredient was considered natural or not. “Natural” is not a single concept and, thus, is difficult to define.Practical applicationsUnderstanding how consumers make decisions about whether a food is “natural” or not is key to understanding how new products are formulated and then perceived by consumers. This study identifies several major issues associated with food ingredients making food seem “not natural.” Most of the issues are associated with a lack of understanding or knowledge or the perception that healthfulness drives naturalness (e.g., if I think it is “healthy” to eat, then it must be natural. The information will better help sensory and other scientists understand perception of their products in a time of consumer confusion.
Applying temporal check‐all‐that‐apply (TCATA) to mouthfeel and texture properties of red wines
Authors: Kemp Belinda , Trussler Steven , Willwerth James , Inglis Debra 
Published: April 2019

AbstractTemporal check‐all‐that‐apply (TCATA) has been used to characterize wines on a nonspecific basis using a range of attributes to investigate sensory differences between wines. The aim of this study was to ascertain whether TCATA, when focused on specific modalities, could distinguish red wines made from the same grape variety, according to mouthfeel and texture descriptors only. Two trained panels evaluated three wines, made from three grape varieties. A combined training approach that used tactile touch standards together with wine sensory evaluation was used to identify mouthfeel and texture sensations. Panelists identified four sensations relevant to all wines: grippy, fine, coarse, and astringent. Differences between wines produced from the same varieties were found for Pinot noir and Cabernet franc but not Cabernet sauvignon. Our results indicate that TCATA is a reliable technique to discriminate red wines according to their mouthfeel and texture profiles during consumption.Practical applicationsThis study investigated the ability of the temporal check‐all‐that‐apply (TCATA) sensory method to distinguish between red wines made from the same grape variety based on mouthfeel and texture properties only. Results from the present work show that TCATA could be used to identify differences in monovarietal wines made from different winemaking techniques.
Bacillus subtilis B21 and Bacillus licheniformis B26 improve intestinal health and performance of broiler chickens with Clostridium perfringens‐induced necrotic enteritis
Authors: Musa Bello Bodinga , Duan Yongle , Khawar Hayat , Sun Qingzhu , Ren Zhouzheng , Elsiddig Mohamed Mohamed Abdalla , Abbasi Imtiaz Hussain Raja , Yang Xiaojun 
Published: April 2019

AbstractThis study investigated the influence of Bacillus‐based probiotics on performance and intestinal health in broiler challenged with Clostridium perfringens‐induced necrotic enteritis. One‐day‐old Arbor Acre (n = 480) were randomly assigned to four treatments with 10 cages of 12 birds: (a) basal diet negative control (NC), with no probiotics nor antibiotics formulated to contain 2,930 and 3,060 kcal/kg with 24.07 and 15.98% CP, for starter and finisher diet, respectively, (b) basal diet + enramycin (5 mg/kg), an antibiotic growth promoter (AGP); (c) basal diet + Bacillus subtilis B21 at 2 × 109 CFU per g (BS); (d) basal diet + Bacillus licheniformis B26 at 2 × 109 CFU per g (BL); growth performance, intestinal morphology, intestinal lesion scores, short‐chain fatty acids (SCFAs) and mucosal barrier tight junction's (TJ) mRNA expression were assessed. NC‐ and BL‐fed groups showed higher (p = 0.005) average daily feed intake from d1 to d21 than AGP and BS, whereas BS‐ and AGP‐fed groups showed higher average daily weight gain from d22 to d42 and d1 to d42 of age. Higher mortality rate of (12.5%) and lower of (5.5%) were recorded in AGP and NC fed‐groups respectively, lesion score was higher in BS and BL than in AGP, while no lesion was observed in NC group, results revealed higher duodenum and jejunum villus height to crypt depth (VH:CD) compared with NC and BS. Probiotics‐fed groups showed higher total (SCFAs), acetic and butyric acid concentrations at d21 post‐challenge (PC) than other groups. The expression of claudin‐1 was upregulated in duodenum (d7) PC and in jejunum (d7) and (d21) PC in BL group, while at d21 PC, the expression of occludens was higher in jejunum and ileum by AGP and BL. The present study indicated both BS and BL have some similarity with AGP in preventing or partially preventing NE effect in broilers.
Using an eddy‐resolving technique to assess the effects of reservoir operation on the bend flow in Yangtze River, China
Authors: Li Jian , Hao Wang , Zhou Yanchen , Chao Nengfang 
Published: April 2019

AbstractWith increasing computing power over the last decade, eddy‐resolving methods in hydraulics engineering have been widely used to investigate the turbulence structure in natural rivers, where accurate field measurements were difficult to conduct and investigate. A detached eddy simulation (DES) model was developed on the basis of the k‐ω‐SST (shear stress transport) eddy‐viscosity model within the framework of an unstructured‐mesh Semi‐implicit Eulerian–Lagrangian Finite Element (SELFE) hydrodynamic model. The DES model was then applied to simulate the bend flow in the upper Yangtze River, and the calculation efficiency was enhanced through parallelized computation to mitigate the high computation costs involved in the DES modelling. The time‐averaged velocity, turbulent intensity and Reynolds stress were compared, using DES modelling and acoustic Doppler current profiler (ADCP) measuring results, indicating good agreement, especially in the near‐bed region. The coupled relationship between the turbulent flow and riverbed terrain was also investigated through extracting and analysing the high‐order statistical variables reflecting the turbulence structure, including non‐hydrostatic pressure, vorticity and helicity, indicating the fluctuated amplitude of non‐hydrostatic pressure can reach to 100 Pa, and the stripe distribution of non‐hydrostatic pressure and vorticity had an orthogonality relation. At the same time, the streamwise velocity at the middle of the HLM bend was found to be decreased at least 0.7 m/s because of unsteady process smoothing and backwater effects attributable to water releases and storage of the reservoirs located upstream and downstream of the HLM bend. The developed unstructured‐mesh DES model will provide a new tool to study turbulent flows in a natural river and assess the effect of reservoir operations on river flows.
Soil carbonate drives local adaptation in Arabidopsis thaliana
Authors: Terés Joana , Busoms Silvia , Perez Martín Laura , Luís‐Villarroya Adrián , Flis Paulina , Álvarez‐Fernández Ana , Tolrà Roser , Salt David E. , Poschenrieder Charlotte 
Published: April 2019

AbstractHigh soil carbonate limits crop performance especially in semiarid or arid climates. To understand how plants adapt to such soils, we explored natural variation in tolerance to soil carbonate in small local populations (demes) of Arabidopsis thaliana growing on soils differing in carbonate content. Reciprocal field‐based transplants on soils with elevated carbonate (+C) and without carbonate (−C) over several years revealed that demes native to (+C) soils showed higher fitness than those native to (−C) soils when both were grown together on carbonate‐rich soil. This supports the role of soil carbonate as a driving factor for local adaptation. Analyses of contrasting demes revealed key mechanisms associated with these fitness differences. Under controlled conditions, plants from the tolerant deme A1(+C) native to (+C) soil were more resistant to both elevated carbonate and iron deficiency than plants from the sensitive T6(−C) deme native to (−C) soil. Resistance of A1(+C) to elevated carbonate was associated with higher root extrusion of both protons and coumarin‐type phenolics. Tolerant A1(+C) also had better Ca‐exclusion than sensitive T6(−C). We conclude that Arabidopsis demes are locally adapted in their native habitat to soils with moderately elevated carbonate. This adaptation is associated with both enhanced iron acquisition and calcium exclusion.
Four Questions of Iterated Grounding
Authors: Kovacs David Mark 
Published: April 2019

The Question of Iterated Grounding (QIG) asks what grounds the grounding facts. Although the question received a lot of attention in the past few years, it is usually discussed independently of another important issue: the connection between metaphysical explanation and the relation or relations that supposedly “back” it. I will show that once we get clear on the distinction between metaphysical explanation and the relation(s) backing it, we can distinguish no fewer than four questions lumped underQIG. I will also argue that given some plausible assumptions about what it would take for a relation to back metaphysical explanation, many salient views about grounding allow us to give “easy” answers to these questions—easy in the sense that we can straightforwardly derive them from the respective conception of grounding without getting into the sorts of complexities that typically inform answers toQIG. The paper's main upshot is that we cannot expect to make much progress onQIGwithout first addressing the difficult issue of how exactly grounding is related to metaphysical explanation.
Bivariate exponentiated‐exponential geometric regression model
Authors: Famoye Felix 
Published: April 2019

A bivariate exponentiated‐exponential geometric regression model that allows negative, zero, or positive correlation is defined and studied. The model can accommodate under‐ or over‐dispersed count data. The regression model is based on the univariate exponentiated‐exponential geometric distribution, and the marginal means of the bivariate model are functions of the explanatory variables. The parameters of the bivariate regression model are estimated by using the maximum likelihood method. Some test statistics including goodness of fit are discussed. A simulation study is conducted to compare the model with the bivariate generalized Poisson regression model. One numerical data set is used to illustrate the application of the regression model.
Survey of instructor and student impressions of a high‐fidelity model in canine ovariohysterectomy surgical training
Authors: Au Yong Jo Anne , Case J. Brad , Kim Stanley E. , Verpaalen Valentine D. , McConkey Marina J. 
Published: April 2019

AbstractObjectiveTo evaluate the usefulness of a high‐fidelity model for teaching ovariohysterectomy (OHE) to veterinary students.Study designLongitudinal survey.Sample populationClinicians with ≥2 years postgraduate experience in small animal surgery and a sophomore veterinary student population at 1 institution.MethodsTwelve clinicians evaluated the high‐fidelity model for realism. Questionnaires were distributed to sophomore veterinary students prior to and after OHE training on the high‐fidelity model (SynDaver Surgical Canine) and after performing OHE as primary surgeon with a live dog. Time for students to perform OHE (identify the first ovarian pedicle to transecting the uterine body) and number of technical errors (visceral injury, hemorrhage, loose ligatures) were compared between the model and live dog groups.ResultsEvaluators rated the high‐fidelity model as moderate‐to‐highly realistic. Students' confidence improved after practicing on the model in all critical steps and additionally improved after performing an OHE on a live dog. Time to complete the OHE on the model (mean ± SD,73.4 ± 27.1 minutes) and live dogs (83.0 ± 24.7 minutes) did not differ (P = .20). Frequency of hemorrhagic events (P =.77) and accidental visceral injury (P =.30) did not differ between the model and live dogs. However, fewer loose ligatures were placed in live dogs (23/64) compared with the model (22/37;P =.02).ConclusionThe high‐fidelity model improved the confidence of sophomore students. The duration of OHE did not differ between the model and live dogs.Clinical impactThe high‐fidelity model is valuable for improving confidence in veterinary students prior to live‐dog OHE.
Bioenergetic basis for the increased fatigability with ageing
Authors: Sundberg Christopher W. , Prost Robert W. , Fitts Robert H. , Hunter Sandra K. 
Published: April 2019

Key points
The mechanisms for the age‐related increase in fatigability during dynamic exercise remain elusive.
We tested whether age‐related impairments in muscle oxidative capacity would result in a greater accumulation of fatigue causing metabolites, inorganic phosphate (Pi), hydrogen (H+) and diprotonated phosphate (H2PO4−), in the muscle of old compared to young adults during a dynamic knee extension exercise.
The age‐related increase in fatigability (reduction in mechanical power) of the knee extensors was closely associated with a greater accumulation of metabolites within the working muscle but could not be explained by age‐related differences in muscle oxidative capacity.
These data suggest that the increased fatigability in old adults during dynamic exercise is primarily determined by age‐related impairments in skeletal muscle bioenergetics that result in a greater accumulation of metabolites.
AbstractThe present study aimed to determine whether the increased fatigability in old adults during dynamic exercise is associated with age‐related differences in skeletal muscle bioenergetics. Phosphorus nuclear magnetic resonance spectroscopy was used to quantify concentrations of high‐energy phosphates and pH in the knee extensors of seven young (22.7 ± 1.2 years; six women) and eight old adults (76.4 ± 6.0 years; seven women). Muscle oxidative capacity was measured from the phosphocreatine (PCr) recovery kinetics following a 24 s maximal voluntary isometric contraction. The fatiguing exercise consisted of 120 maximal velocity contractions (one contraction per 2 s) against a load equivalent to 20% of the maximal voluntary isometric contraction. The PCr recovery kinetics did not differ between young and old adults (0.023 ± 0.007 s−1 vs. 0.019 ± 0.004 s−1, respectively). Fatigability (reductions in mechanical power) of the knee extensors was ∼1.8‐fold greater with age and was accompanied by a greater decrease in pH (young = 6.73 ± 0.09, old = 6.61 ± 0.04) and increases in concentrations of inorganic phosphate, [Pi], (young = 22.7 ± 4.8 mm, old = 32.3 ± 3.6 mm) and diprotonated phosphate, [H2PO4−], (young = 11.7 ± 3.6 mm, old = 18.6 ± 2.1 mm) at the end of the exercise in old compared to young adults. The age‐related increase in power loss during the fatiguing exercise was strongly associated with intracellular pH (r = –0.837), [Pi] (r = 0.917) and [H2PO4−] (r = 0.930) at the end of the exercise. These data suggest that the age‐related increase in fatigability during dynamic exercise has a bioenergetic basis and is explained by an increased accumulation of metabolites within the muscle.
PO 8447 ROBUST CLINICAL TRIALS ARE NOT ENOUGH: OVERCOMING OPERATIONAL CHALLENGES FOR IMPLEMENTING REMSTART INTERVENTION PACKAGE (TRIP STUDY) INTO ROUTINE PRACTICE
Authors: Kivuyo Sokoine , Erick Frank , Loyse Angela , Jaffar Shabar , Mfinanga Godfrey S 
Published: April 2019

BackgroundThe REMSTART trial identified an effective package (cryptococcal antigen (CrAg) screening and enhanced antiretroviral therapy (ART) adherence support) that reduced all-cause mortality in advanced HIV (CD4 ≤200 cells/mm3) by 28% compared to standard of care. The introduction of this package at clinic level has been necessary to impact routine care practices in Tanzania.MethodsThe TRIP study is cluster-randomised. The intervention package was implemented in 16 routine care facilities (early arm) whilst 8 facilities continued with standard of care (deferred arm). At the end of 12 months follow-up, the intervention was implemented in the deferred facilities. The primary endpoint is all-cause mortality at 1 year.ResultsImplementation of the REMSTART intervention into routine care services has highlighted the following challenges: 1) Baseline CD4 testing: half (4/8) of rural facilities had no CD4 machines and in a further 3/8 there was a lack of reagents needed for CD4 testing. Clinical staging has replaced inclusion criterion where CD4 testing is not available; 2) Heavy staff workload in routine care; regular discussion with policymakers and workshops enhanced the take-up of the package; 3) Timing of ART: the Ministry of Health has updated national guidelines to include the package and delay ART by 2 weeks in CrAg-positives.ConclusionIt has proven essential to engage with policymakers and programme managers from the outset, i.e. during the REMSTART trial itself and the following TRIP implementation study. The Ministry of Health has now changed the national HIV guidelines to include the REMSTART package and develop training modules for CrAg screening in all regional hospitals. The TRIP study has revealed key issues that must be addressed to allow scaling up the interventions.
PO 8471 A SURVEY OF CURRENT CLINICAL DATA MANAGEMENT PRACTICES IN SUB-SAHARAN AFRICA
Authors: Landuyt Hanne , Loen Harry Van , Dondeh Bai L , Gaye Badou M , Herrewege Yven Van 
Published: April 2019

BackgroundInformation on clinical data management (CDM) practices in clinical trials in sub-Saharan Africa is scarce. As part of ALERRT (the African coalition for Epidemic Research, Response and Training, an EDCTP-funded project) we want to gauge current CDM and ICT practices and identify possible gaps within different research institutions in sub-Saharan Africa. This information will be used to develop a scalable, GCP-compliant, robust CDM/ICT infrastructure suitable for resource-poor settings and response-ready in the event of an outbreak.MethodsAn online survey was designed to assess the experience of the participating sites with the various CDM processes, CDM documentation and facilities, the availability of dedicated staff and their experience with GCP. In addition, ICT features essential to CDM will be assessed. Lastly, information on the use of CDM software will be obtained. Respondents can request to receive personalised feedback (aimed to improve their CDM practices) based on their results. The survey, in English and French, will be sent out to 100 sites in sub-Saharan Africa. Sites with intermittent internet connections will receive an MS-Office Word-version of the survey.ResultsThe survey will be closed after a month. Personalised feedback (if requested) will be sent to the respondents. Descriptive analysis of the survey results will be done, and results will be used to design standard data management tools, tailored to the needs of research sites in sub-Saharan Africa and suitable for emergency research. Both results and tools will be disseminated to the scientific community.ConclusionThe results of this survey will provide relevant information on the current CDM and ICT practices in sub-Saharan Africa. Potential pitfalls will be identified and opportunities for improvement will be addressed. Furthermore, the survey will offer a chance to exchange ideas between African and European partners on how to implement good CDM and ICT practices.
PO 8480 TECHNICAL FEASIBILITY OF SENDING SMS TO REMIND TAKING MEDICATION AMONG PREGNANT AND BREASTFEEDING WOMEN LIVING WITH HIV IN KILIMANJARO, TANZANIA
Authors: Ngowi Kennedy M , Maro Eusibious , Nieuwkerk Pythia T , Aarnoutse Rob E , Mmbaga Blandina T , Marion Sumari-De Boer I 
Published: April 2019

BackgroundPregnant women living with HIV have difficulties in reaching adequate levels of adherence to treatment. One way to intervene is sending reminder cues using short message service (SMS) texts. We conducted a pilot study on the use of SMS among pregnant and breastfeeding women living with HIV in Kilimanjaro, Tanzania. One objective was to investigate technical feasibility of sending SMS reminders.MethodsWe enrolled adult (age 18–45) pregnant or breastfeeding women living with HIV from Kilimanjaro region, Tanzania. Women received a reminder SMS 30 min before usual time of intake. One hour after usual time of intake, they received an SMS asking whether she took medication. The women had to reply with ‘Yes’ or ‘No’. SMSes were sent less-than-daily and randomly distributed over the week. We did descriptive analyses of sent messages, delivered messages and estimation of adherence based on messages.ResultsWe enrolled 25 women. In total, 4963 messages were sent of which 40 failed to be delivered (1%). 1664 SMS were sent with a question if medication was taken, wich received an answer 1580 times (91%). The answer was ‘Yes’ in 1137 cases (65%), ‘No’ in 10 cases (0.6%) and indefinable in 433 cases (26%). The median adherence based on ‘Yes’-answers was 74% [range 24–99]. If also counting the indefinable answers, the mean adherence was 100% [range 95–100].ConclusionDespite a few technical issues, we believe using SMS for reminder cues in Tanzania works well. The number of failed deliveries is nearly zero and women have replied to the majority of SMS. Efforts are needed to instruct women better on replying and on detecting the right answer in case of typing errors. We conclude that using SMS has potential to improve adherence and should be further investigated in clinical trials to determine the effect on adherence to treatment.