bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triggering MSR1 promotes JNK-mediated inflammation in IL-4 activated macrophages
Authors: Guo Manman , Härtlova Anetta , Gierliński Marek , Prescott Alan , Castellvi Josep , Losa Javier Hernandez , Petersen Sine K. , Wenzel Ulf A. , Dill Brian D. , Emmerich Christoph H. , Cajal Santiago Ramon Y , Russell David G. , Trost Matthias 
Published: August 2018

SummaryAlternatively activated M2 macrophages play an important role in maintenance of tissue homeostasis by scavenging dead cells, cell debris and lipoprotein aggregates via phagocytosis. Using proteomics, we investigated how alternative activation, driven by IL-4, modulated the phagosomal proteome to control macrophage function. Our data indicate that alternative activation enhances homeostatic functions such as proteolysis, lipolysis and nutrient transport. Intriguingly, we identified the enhanced recruitment of the TAK1/MKK7/JNK signalling complex to phagosomes of IL-4 activated macrophages. The recruitment of this signalling complex was mediated through K63-polyubiquitylation of the macrophage scavenger receptor 1 (MSR1). Triggering of MSR1 in IL-4 activated macrophages leads to enhanced JNK activation, thereby promoting a phenotypic switch from an anti-inflammatory to a pro-inflammatory state, which was abolished upon MSR1 deletion or JNK inhibition. Moreover, MSR1 K63-polyubiquitylation correlated with the activation of JNK signalling in ovarian cancer tissue from human patients, suggesting that it may be relevant for macrophage phenotypic shift in vivo. Altogether, we identified that MSR1 signals through JNK via K63-polyubiquitylation and provide evidence for the receptor’s involvement in macrophage polarization.
High-involvement human resource practices, employee learning and employability
Authors: Liu Wei 
Published: August 2018

PurposeAlthough environmental factors at the organizational level are of importance for individual employability, very few studies have investigated how the practices an organization implements can facilitate employability. The purpose of this paper is to analyze how high-involvement human resources (HIHR) practices (i.e. recognition, competence development, empowerment, information sharing and fair rewards) influence employee learning, which contributes to employability.Design/methodology/approachThe data were collected from 288 pairs of employees and their direct supervisors in Chinese companies. In this study, we measure perceived employability from both employees and their direct supervisors. Structural equation modeling (SEM) analysis is conducted to test the hypotheses.FindingsThe results indicate that employees’ perceptions of the HIHR practices of recognition, competence development, empowerment and information sharing are positively related to employee learning, and then facilitate self- and supervisor-ratings of employees’ employability. Practices of fair rewards have a negative effect on employee learning and employability.Originality/valueThis study contributes to employability and human resource management literature in several ways. First, the study raises the association between different HIHR practices and perceived employability through employee learning. Second, the study considers both self-rating and supervisor-rating of employability to improve the effectiveness of the results.
Institutional barriers to women’s employment in Saudi Arabia
Authors: Alfarran Abeer , Pyke Joanne , Stanton Pauline 
Published: August 2018

Purpose
The purpose of this paper is to explore the effectiveness of the Saudi employment programme “Nitaqat” in addressing institutional barriers to women’s employment in the Saudi private sector. The paper has a particular focus on the perspectives of unemployed women as the intended recipients of increased employment opportunities.

Design/methodology/approach
This paper adopts a qualitative approach, drawing on findings from face-to-face interviews conducted with two groups of stakeholders, government officials and unemployed Saudi women.

Findings
Four key findings are identified. First, the considerable cultural and regulatory barriers of a conservative society are resilient impediments to the success of Saudi employment policy. Second, discrimination against women is endemic in the Saudi society; however, it is largely unrecognised within the Saudi culture and often accepted by women themselves. Third, due to government regulations, cultural constraints and the gendered educational system, the private sector contributes to sustaining labour market segmentation through discriminatory practices. Finally, while a positive change is taking place in Saudi Arabia regarding women’s employment, it is incremental and uneven.

Originality/value
This paper provides new insights into the institutional barriers related to the labour force participation of Saudi women from the perspective of Saudi women themselves.
Validity of self-reported conflict handling preferences and the role of self-enhancement
Authors: Johnson Kirsten E. , Hall Judith A. 
Published: August 2018

PurposeThis paper aims to assess predictive and convergent validity of a trait measure of conflict handling styles (DUTCH) with two alternative methods of measuring such styles: a vignette measure of behavioral choices (CB-Pref) and behavior in a role-played conflict. In addition, this paper investigates self-enhancement in responses to the two self-report measures.Design/methodology/approachIn Studies 1 (N= 117), 2 (N= 116) and 4 (N= 68), participants completed the DUTCH and CB-Pref. In Study 3 (N= 56 dyads), participants completed the DUTCH and a role-played conflict. In Study 4, participants also responded to the measures as either a typical person or an ideal person would.FindingsThe DUTCH predicted four of five styles individuals chose across nine vignettes of the CB-Pref. In Study 4, the DUTCH predicted three of the five. In Study 3, only the DUTCH’s forcing style predicted actual behavior. In Study 4, participants rated themselves as more constructive and less destructive than typical, but less constructive than ideal. Participants in general were somewhat self-enhancing on both self-report measures, but individual differences in social desirability were generally unrelated to self-report responses.Originality/valueThis work takes a multi-method approach to assessing the validity of a self-report conflict style measure, allowing for the assessment of the measure’s predictive and convergent validity when predicting self-reported style tendencies to style selected in vignettes and behavior in a role-played conflict.
Informing quality in emergency care: understanding patient experiences
Authors: Swallmeh Esmat , Byers Vivienne , Arisha Amr 
Published: August 2018

PurposeAssessing performance and quality in healthcare organisations is moving from focussing solely on clinical care measurement to considering the patient experience as critical. Much patient experience research is quantitative and survey based. The purpose of this paper is to report a qualitative study gathering in-depth data in an emergency department (ED).Design/methodology/approachThe authors used empirical data from seven focus groups to understand patient experience as participants progressed through a major teaching hospital in an Ireland ED. A convenience sampling technique was used, and 42 participants were invited to share their perceptions and outline key factors affecting their journey. A role-playing exercise was used to develop improvement themes. Data were analysed using thematic analysis and data analysis software (NVivo 10).FindingsCapturing ED patient experience increases our understanding and process impact on the patient journey. Factors identified include information, access, assurance, responsiveness and empathy, reliability and tangibles such as surroundings, food and seating.Research limitations/implicationsOwing to the ED patient’s emergency nature, participants were recruited if triaged at levels 3–5 (Manchester Triage System). The study explored patients’ immediate rather thanpost hocexperiences where recollections may change over time.Originality/valueTo the authors’ knowledge, no study has examined in-depth, ED patient experience in Ireland using qualitative interviewing, obtaining critical process insights as it occurs. The potential to inform patient process improvements in Irish EDs is significant.
Infant mortality rate in India: mediating causes
Authors: Arockiasamy Arulraj , Anburose Antonyraj 
Published: August 2018

Purpose
The purpose of this paper is to develop a new approach to health service quality assurance.

Design/methodology/approach
Data were collected using a structured, eight-section questionnaire. Stratified random samples were drawn from four villages based in four Indian regions.

Findings
Psychological discomfort is an infant mortality rate (IMR) mediating factor. The root mean square error of approximation fit statistic for the model was 0.08, which was considered the best fit.

Practical implications
Addressing mediating causes can reduce IMR in developing countries.

Originality/value
The model that the authors described helps health institution managers to map quality assurance health management and economics.
An integrative approach to improving patient care pathways
Authors: Williams Sharon , Radnor Zoe 
Published: August 2018

Purpose
Globally, healthcare managers continue to struggle with increasing demands for their services being delivered with limited or shrinking resources. It is, therefore, clear that systems, processes and practices need to change to meet these challenges. The purpose of this paper is to assess how integrating two improvement technologies, Lean and integrated care pathways (ICP) might help.

Design/methodology/approach
Lean and ICP in healthcare provide a platform to develop conceptual frameworks for integrating two approaches.

Findings
A conceptual integrated framework is provided to assist care pathway designers and implementers to consider the synergistic benefits of combining approaches to improvement.

Research limitations/implications
The authors provide a conceptual framework that requires empirically testing.

Practical implications
This research provides a conceptual framework to aid practitioners to improve healthcare design and delivery.

Originality/value
For the first time, the authors bring together two approaches to improving patient care pathway design and consider how these are linked in relation to improving healthcare delivery.
Levelling bed occupancy: reconfiguring surgery schedules via simulation
Authors: Yip Kenneth , Leung Louisa , Yeung Deacons 
Published: August 2018

Purpose
The purpose of this paper is to present simulation modelling to reconfigure a 700-bed Hong Kong hospital’s master surgery schedule (MSS), aiming to improve patient flow, capacity management and resource allocation through levelling bed occupancy within the hospital.

Design/methodology/approach
A discrete-event simulation model was developed to understand how changes to the MSS would affect bed occupancy, thereby providing business intelligence for short- and long-term hospital planning. A decision tool was subsequently developed for hospital managers to test different scenarios.

Findings
Simulation modelling showed that significant bed occupancy levelling could be achieved through small and practicable changes to the MSS. Optimisation routines conducted using the simulation model then gave additional insights into how the schedule should be revamped for the long term.

Practical implications
The authors show how operations research methods are useful for guiding hospital operational planning. The authors show that a data-driven and evidence-based model enables hospital managers to critically explore various scheduling changes, while also providing a scientific common ground for discussion among important stakeholders. It is a crucial step forward when adopting advanced analytics for Hong Kong hospital operational planning.

Originality/value
The authors provide a robust method for evaluating the relationship between Hong Kong hospital’s MSS and its bed occupancy. Through simulating various changes to the surgical schedule, valuable and practicable insights were made available for hospital managers to make short- and longer-term changes that enhance the system’s overall efficiency and service quality.
Estimating facilities maintenance cost using post-occupancy evaluation and fuzzy set theory
Authors: Alshibani Adel , Hassanain Mohammad A. 
Published: August 2018

PurposeThe purpose of this paper is to introduce a new general approach for estimating the maintenance cost of constructed facilities. The proposed approach consists of four components, including: facility work breakdown structure; historical maintenance cost and cost contingency data of actual completed projects; feedback obtained from the post-occupancy evaluation (POE); and fuzzy set theory (FST) to define the uncertainty associated with the maintenance cost and cost contingency as an alternative approach to simulation.Design/methodology/approachLiterature review of the existing methods used for estimating maintenance cost of constructed facilities was conducted to highlight the limitations of the existing methods and models. The paper then introduced a new approach in which the results obtained from POE are integrated with the estimator’s judgment in estimating maintenance cost of constructed facility. As a proof of concept, the developed approach is tested on a private school facility in the city of Khobar, Saudi Arabia. The application of the proposed approach in this case project demonstrates its applicability and features in comparison with the existing practice.FindingsThe application of the developed approach on a school case project demonstrated that the developed approach can provide a reliable facility maintenance cost estimate, narrow the uncertainties and vagueness associated with the estimated cost, and provide the estimator with the necessary information to conduct risk analysis with less effort, less computations and less complexity comparing with that provided by complex simulation. The results also showed that integrating POE in the estimating process can provide more accurate cost estimate with high level of confidence.Originality/valueThe paper presents a new approach for estimating facility maintenance cost. The developed approach introduced a new concept that assists maintenance contractors in preparing facility maintenance estimate with improved accuracy while satisfying the facility user’s needs. The proposed approach integrates the estimator’s judgment with POE to model the uncertainties associated with cost using FST as an alternative approach for complex simulation.
Linkages between empowering leadership and subjective well-being and work performance via perceived organizational and co-worker support
Authors: Kim Daeho , Moon Chul Woo , Shin Jiseon 
Published: August 2018

PurposeThe purpose of this paper is to examine the effects of empowering leadership at the team level on employees’ subjective well-being (SWB) and work performance through perceived social support. Based on social exchange theory (Blau, 1964), the study identifies the mediating effects of perceived social support in the relationship between empowering leadership and both employees’ well-being and work performance.Design/methodology/approachThe study utilized a survey of 1,225 employees working for an organization in South Korea and archival data of the organization. It employed hierarchical linear modeling analyses and the CWC(M) procedure for the tests of multilevel mediation.FindingsIt was observed that perceived organizational support (POS) and co-worker support (PCS) mediated the relationship between empowering leadership and SWB, but not the relationship between empowering leadership and performance. There was a significant direct effect of empowering leadership on both POS and PCS, which subsequently led to improved work performance.Originality/valueTaking a multilevel approach to leadership and relying on both self-reported and organizational archival data, this study contributes to the literature on leadership and well-being by examining the relationships between empowering leadership toward a team and team members’ well-being and performance, and by revealing the crucial mechanisms that underlie them. The study helps to elucidate the impact of empowering leadership on employee SWB, which has largely been neglected in prior management research.
Key mechanisms underlying netrin‐1 prevention of impaired spatial and object memory in Aβ1‐42 CA1‐injected rats
Authors: Zamani Elham , Parviz Mohsen , Roghani Mehrdad , Mohseni‐moghaddam Parvaneh 
Published: August 2018

SummaryAlzheimer's disease (AD) is a neurodegenerative disorder with an incompletely defined aetiology that is associated with memory and cognitive impairment. Currently available therapeutics only provide temporary assistance with symptoms. In spite of plentiful research in the field and the generation of thousands of studies, much is still to be clarified on precise mechanisms of pathobiology, prevention modalities, disease course and cure. Netrin‐1, a laminin family protein, is said to have anti‐inflammatory and anti‐apoptotic effects and has a key role in neurogenesis and morphogenesis of neural structures. Accordingly, this study was designed to investigate protective effects of bilateral intrahippocampal fissure microinjections of netrin‐1 on memory impairment in rat model of AD. Concomitant administration of netrin‐1 with amyloid beta 1‐42 (Aβ1‐42) improved cognitive dysfunction in novel object recognition task (NOR), ameliorated impaired spatial memory in Morris water maze (MWM) setting, increased neuronal density and reduced amyloid aggregation in rat AD model. Netrin‐1 was also seen to prevent Aβ1‐42‐induced caspase‐3, caspase‐7 and NF‐κB (nuclear factor kappa‐light‐chain‐enhancer of activated B cells) activation. Therefore, based on the data reported here, netrin‐1 may be a promising biologic therapeutic that addresses the memory and neuronal loss associated with AD.
FAS A‐670G and Fas ligand IVS2nt A 124G polymorphisms are significantly increased in women with pre‐eclampsia and may contribute to HELLP syndrome: a case‐controlled study
Authors: Raguema N , Zitouni H , Ben Ali Gannoun M , Benletaifa D , Almawi WY , Mahjoub T , Lavoie JL 
Published: August 2018

ObjectiveWe evaluated the association between the Fas‐670A/G and the Fas ligand FasL IVS2nt 124 A/G polymorphisms and the risk of pre‐eclampsia and its complications.DesignA case‐controlled study.SettingUniversity Hospitals in most areas of Tunisia.PopulationWe recruited 300 pregnant women who developed pre‐eclampsia and 300 age‐matched healthy pregnant women from the same hospital.MethodsGenotyping of Fas‐670A/G and the FasL IVS2nt 124A/G gene polymorphisms were conducted using polymerase chain reaction‐restriction fragment length polymorphism among our cohort.Main outcome measuresFisher's exact test was used to compare the statistical differences between groups for categorical variables and Student t tests were used for continuous variables.ResultsThe frequency of the Fas‐670G gene variant was significantly increased in women with pre‐eclampsia (42%) compared with control women (30%; P < 0.001). Also, a statistically significant difference was obtained in the distribution of the FasL IVS2nt 124G gene variant when comparing women with pre‐eclampsia (43%) with controls (30%; P < 0.001). Interestingly, we found that the carriage of Fas‐670G was associated with increased liver enzymes, suggesting an increased prevalence of the haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome, a pre‐eclampsia complication.ConclusionThe Fas‐670G and FasL IVS2nt 124G polymorphisms are associated with a higher risk of pre‐eclampsia and its complications.Tweetable abstractPolymorphisms in the Fas and FasL genes are associated with increased risk of pre‐eclampsia and HELLP syndrome.
Performance of SAPS II according to ICU length of stay: Protocol for an observational study
Authors: Granholm Anders , Christiansen Christian Fynbo , Christensen Steffen , Perner Anders , Møller Morten Hylander 
Published: August 2018

BackgroundSeverity scores, including the Simplified Acute Physiology Score (SAPS) II, are widely used in the intensive care unit (ICU) to predict mortality outcomes using data from ICU admission or shortly hereafter. For patients with longer ICU length of stay (LOS), the predictive performance of admission‐based severity scores may deteriorate compared to patients with shorter ICU LOS. This protocol and statistical analysis plan outlines a study that will assess the influence of ICU LOS on the performance of SAPS II for predicting 90‐day post‐ICU mortality.MethodsA Danish nationwide cohort study including adult (≥18 years) ICU patients admitted to a Danish ICU between 1 January 2012 and 30 June 2016. The study will be conducted using the Danish Intensive Care Database (DID), which contains data routinely, prospectively, and consecutively reported for all Danish ICU admissions. Discrimination of SAPS II for predicting 90‐day post‐ICU mortality will be assessed for the entire cohort and stratified according to ICU LOS. A first‐level recalibration of SAPS II will be performed, and if adequate, standardised mortality ratios and calibration stratified according to ICU LOS will be reported.ConclusionsThe outlined large, nationwide cohort study will provide important, contemporary information about the influence of ICU LOS on severity score performance relevant for ICU clinicians, researchers, and administrators. Publication of the protocol and statistical analysis plan prior to study conduct ensures transparency, and limits the risk of publication bias, post hoc changes in analyses, and challenges with multiple comparisons.
Explicit Attitudes, Working Memory Capacity, and Driving After Drinking
Authors: Hatz Laura E. , McCarty Kayleigh N. , Bartholow Bruce D. , McCarthy Denis M. 
Published: August 2018

BackgroundAttitudes toward driving after drinking are strongly predictive of drinking and driving behavior. This study tested working memory capacity (WMC) as a moderator of the association between attitudes and drinking and driving behavior. Consistent with dual process models of cognition, we hypothesized that the association between perceived danger and drinking and driving would be stronger for individuals with higher WMC.MethodsParticipants (N = 161) enrolled in larger alcohol administration study were randomly assigned to an alcohol (n = 57), placebol (n = 52), or control (n = 52, not included) beverage condition. Past‐year frequency of driving after drinking and WMC were assessed at baseline. Attitudes were assessed by asking participants to rate the perceived danger of driving at their current level of intoxication twice on the ascending limb (AL1, AL2), at peak breath alcohol concentration (BrAC), and twice on the descending limb (DL1, DL2).ResultsAnalyses across the BrAC curve indicated that the hypothesized interaction was observed for the alcohol but not placebo condition. Analyses for each assessment point indicated that the interaction was significant for the ascending limb and peak BrAC. In the alcohol condition, for those higher in WMC, lower perceived dangerousness was strongly associated with increased driving after drinking (AL1: incident rate ratios [IRR] = 5.87, Wald's χ2 = 12.39, p = 0.006, 95% CI [2.19, 15.75]; AL2: IRR = 8.17, Wald's χ2 = 11.39, p = 0.001, 95% CI [2.41, 27.66]; Peak: IRR = 5.11, Wald's χ2 = 9.84, p = 0.002, 95% CI [1.84, 14.16]). Associations were not significant at low WMC.ConclusionsResults suggest that individuals higher in WMC are more likely to act consistently with their explicit attitudes toward drinking and driving. Findings may have implications for existing drinking and driving interventions and suggest the potential for novel interventions targeting implicit associations or WMC.