bluuebunny/crossref_metadata_2025_split huggingface dataset:
Favorable inhibitory effect of clodronate on hepatic steatosis in short bowel syndrome model rats
Authors: Tsuruno Yudai , Nagano Ayaka , Sugita Koshiro , Onishi Shun , Tabata Yumiko , Kedoin Chihiro , Murakami Masakazu , Yano Keisuke , Kawano Takafumi , Hasuzawa Nao , Nomura Masatoshi , Kaji Tatsuru , Bitoh Yuko , Ieiri Satoshi 
Published: November 2024

Abstract
Purpose
This study investigated the anti-inflammatory effect of clodronate, a vesicular nucleotide transporter (VNUT) inhibitor, on intestinal-failure-associated liver disease (IFALD) in a rat model of short bowel syndrome (SBS).

Methods
The rats underwent jugular vein catheterization for continuous total parenteral nutrition (TPN) and 90% small bowel resection. The animals were divided into the following groups: TPN/SBS (Control group), TPN/SBS/intravenous administration of low-dose clodronate (20 mg/kg twice per week; Low group), or TPN/SBS/intravenous administration of high-dose clodronate (60 mg/kg twice per week; High group). On day 7, the rats were euthanized. Hepatic steatosis and hepatocellular injury were also assessed.

Results
Hepatic steatosis and lobular inflammation in the liver were observed in all groups. The High group showed histologically reduced hepatic steatosis compared with the Control group. IL-6 and Nlrp3 expression in the High group was significantly suppressed compared to that in the Control group. The expression of other inflammatory cytokines tended to be lower in the High dose group than in the control group. The lipid metabolism gene expression in the liver specimens showed no significant differences among the groups.

Conclusion
The high-dose administration of clodronate may, therefore, inhibit hepatic steatosis and inflammation associated with IFALD in patients with SBS.
Messung des krankheitsbezogenen Wissens von Patient*innen mit axialer Spondyloarthritis – Entwicklung und Anwendung des G-ASKQ7-Fragebogens
Authors: Schuster Louis , Henes Jörg , Diener Matthias , Mühlensiepen Felix , Andreica Ioana , Hueber Axel , Schett Georg , Knitza Johannes 
Published: November 2024

Zusammenfassung
Hintergrund/Ziel
Patientenedukation ist integraler Bestandteil der Behandlung von Patient*innen mit axialer Spondyloarthritis (axSpA). Allerdings sind die verfügbaren validen Messinstrumente zur Erhebung des krankheitsbezogenen Wissens veraltet und im Falle der axSpA nur in englischer Sprache verfügbar. Die Ziele dieser Studie waren daher (1) die Entwicklung eines geeigneten deutschsprachigen Instruments zur Messung krankheitsspezifischen Wissens bei axSpA-Patient*innen und (2) die Pilotierung dieses Instruments.

Methoden
Verfügbare Messinstrumente speziell für die axSpA wurden von einem Expertengremium geprüft, und ein Entwurf des aktuellen G‑ASKQ7 wurde abgestimmt. Nach Evaluation der Augenscheinvalidität und entsprechenden Anpassungen wurden erwachsene konsekutive axSpA-Patient*innen der rheumatologischen Hochschulambulanz des Universitätsklinikums Erlangen gebeten, den Fragebogen auszufüllen. Es wurden Korrelationen zwischen dem erreichten Summenscore und weiteren erhobenen Parametern (Alter, Geschlecht und Krankheitsdauer) untersucht.

Ergebnisse
Der entwickelte G‑ASKQ7-Fragebogen umfasst 7 Fragen, wurde als leicht verständlich bewertet und innerhalb von durchschnittlich 6,3 ±2,0 min ausgefüllt; 65 axSpA-Patient*innen (36 Frauen; mittleres Alter: 45,3 ± 12,4 Jahre; mittlere Erkrankungsdauer: 8,6 ±7,3 Jahre) beantworteten den finalen Fragebogen. Der G‑AKSQ7-Mittelwert lag bei 17,8/25 und war bei Frauen (19,0/25) signifikant höher als bei Männern (16,3/25) (p = < 0,05). Am häufigsten wurde Frage 7 (79,3 %) mit Hinblick auf das Selbstmanagement der Erkrankung korrekt beantwortet. Frage 4 mit Blick auf die Messung der Krankheitsaktivität wurde am schlechtesten beantwortet (55,8 %). Es konnte keine signifikante Korrelation zwischen der Krankheitsdauer (p = 0,57; r = 0,07; Pearson-Korrelationstest) oder dem Alter (p = 0,67; r = −0,05; Pearson-Korrelationstest) und dem krankheitsbezogenen Wissen festgestellt werden.

Diskussion
Der G‑ASKQ7 bietet erstmals ein deutschsprachiges Instrument zur Ermittlung des krankheitsspezifischen Wissens von axSpA-Patient*innen. Durch eine routinemäßige Erhebung mittels G‑ASKQ7 kann der individuelle Wissensbedarf von Patient*innen niedrigschwellig ermittelt werden, und Edukationsinhalte können gezielt auf Patient*innen abgestimmt werden. Eine kontinuierliche Aktualisierung und weitere Evaluationsstudien sind erforderlich.
Nowcasting GDP using machine learning methods
Authors: Kant Dennis , Pick Andreas , Winter Jasper de 
Published: November 2024

AbstractThis paper compares the ability of several econometric and machine learning methods to nowcast GDP in (pseudo) real-time. The analysis takes the example of Dutch GDP over the period 1992Q1–2018Q4 using a broad data set of monthly indicators. It discusses the forecast accuracy but also analyzes the use of information from the large data set of macroeconomic and financial predictors. We find that, on average, the random forest provides the most accurate forecast and nowcasts, whilst the dynamic factor model provides the most accurate backcasts.
Functional characterization of OR51B5 and OR1G1 in human lung epithelial cells as potential drug targets for non-type 2 lung diseases
Authors: Awad Noha , Weidinger Daniel , Greune Lea , Kronsbein Juliane , Heinen Natalie , Westhoven Saskia , Pfaender Stephanie , Taube Christian , Reuter Sebastian , Peters Marcus , Hatt Hanns , Fender Anke , Knobloch Jürgen 
Published: November 2024

Abstract
Background
Hypersensitivity to odorants like perfumes can induce or promote asthma with non-type 2 inflammation for which therapeutic options are limited. Cell death of primary bronchial epithelial cells (PBECs) and the release of the pro-inflammatory cytokines interleukin-6 (IL-6) and IL-8 are key in the pathogenesis. Extra-nasal olfactory receptors (ORs) can influence cellular processes involved in asthma. This study investigated the utility of ORs in epithelial cells as potential drug targets in this context.

Methods
We used the A549 cell line and primary bronchial epithelial cells using air–liquid interface culture system (ALI-PBECs). OR expression was investigated by RT-PCR, Western blot, and Immunofluorescence. Effects of OR activation by specific ligands on intracellular calcium concentration, cAMP, Phospholipase C (PLC), cell viability, and IL-6 and IL-8 secretion were analyzed by calcium imaging, enzyme immunoassays, Annexin V/ propidium iodide -based fluorescence-activated cell staining or by ELISA, respectively.

Results
By screening A549 cells, the OR51B5 agonists Farnesol and Isononyl Alcohol and the OR1G1 agonist Nonanal increased intracellular Ca2 + . OR51B5 and OR1G1 mRNAs and proteins were detected. Both receptors showed a preferential intracellular localization. OR51B5- but not OR1G1-induced Ca2 + dependent on both cAMP and PLC signaling. Farnesol, Isononyl Alcohol, and Nonanal, all reduced cell viability and induced IL-8 and IL-6 release. The data were verified in ALI-PBECs.

Conclusion
ORs in the lung epithelium might be involved in airway-sensitivity to odorants. Their antagonism could represent a promising strategy in treatment of odorant-induced asthma with non-type 2 inflammation.

Graphical Abstract
Online Teacher Professional Development: A Research Synthesis on Effectiveness and Evaluation
Authors: Stavermann Kristin 
Published: November 2024

AbstractThis study presents findings on the effectiveness and perception of teacher professional development in online-only and blended learning (BL) formats. The analysis of a total of 115 studies from the research field of online teacher professional development (OTPD) showed that digitized training predominantly led to positive effects on teachers' competencies and teaching practice. Among some of the other positive impacts of OTPD were improvements in students' learning performance, attitudes and motivations, and teachers' self-efficacy; though these aspects were considered much less frequently overall. Despite individual criticisms and suggestions for improvement, OTPD courses were endorsed by teachers. In terms of the take-up amongst participants, online-only and BL formats scored similarly, with the inclusion of synchronous phases, collaborative activities, and support activities proving to be decisive criteria for evaluation. In context of support activities, the involvement of an instructor was found to be effective, although it became clear that it is not only the presence of an instructor that matters, but also the way in which he is involved in the OTPD activity (Lantz-Andersson et al. Teach Teach Educ 75:302-315, 2018 ). A basic open attitude towards OTPD was also held by the training staff, even when complications and difficulties were pointed out.
An Ambivalent Coexistence: Jews and Christians in Late Ottoman Edirne
Authors: Karkason Tamir 
Published: November 2024

AbstractThis article discusses the relations between Jews and Christians in Edirne during the late Ottoman period. At the time, approximately half the city’s inhabitants were Greeks, and at least ten percent were Jews. The Jewish quarter of the city was surrounded by areas with a Greek majority, while a few Armenians also lived alongside the Greeks and Jews. Drawing on diverse sources from the Ladino, Hebrew, French, English, and Greek press, I argue that an ambivalent coexistence prevailed between Jews and Christians in Edirne, where hostility and enmity acted as catalysts for, rather than obstacles to, transculturation. Analysis of two case studies illustrate this ambivalent coexistence. The first concerns the reflection of the blood libel waged by Greeks in Istanbul in 1874 in Jewish and Armenian discourse in Edirne. The second is the discourse on the historical symbiosis between Jews and Greeks embodied in lectures by the maskil Abraham Danon in 1892 to a Greek audience in the city. Both issues sparked considerable interest among Jews and Christians, not only within the Ottoman Empire but also throughout the global Jewish and Greek diasporas.
Eye-Gaze Training Does Not Impact Performance on a Nonverbal Test of Reading Abilities for Children with Special Educational Needs
Authors: Arnold Sharon , Reed Phil 
Published: November 2024

AbstractMany individuals in special education have difficulty with language, and little is known about their reading abilities due to challenges presented for assessment. A nonverbal word recognition test based was developed by Measuring the word recognition abilities of children who are (2019), which proved more sensitive than traditional reading tests. The current Experiment 1 replicated that result for children in special education, and noted that the modified reading test was especially sensitive for those who do not score well in traditional versions of reading and language assessments. However, removing the motor response required by the digitised response, in favour of using eye-tracking responses, did not aid assessment of reading performance. Experiment 2 tested the notion that it could be that participants unfamiliar with use of eye gaze tracking facilities may not respond well to such a test. Reading scores for two groups of pupils in special education were compared: a group who took part in ‘primer activities’ designed to encourage familiarity with eye gaze tracking, and a group who received no such intervention. There was no impact of eye gaze training on the results of the eye-gaze modulated modified nonverbal reading test, suggesting that manual responses are the most effective way of assessing word recognition.
The Role of Videogame Micro-Transactions in the Relationship Between Motivations, Problem Gaming, and Problem Gambling
Authors: Gibson Erin , Griffiths Mark D. , Calado Filipa , Harris Andrew 
Published: November 2024

AbstractEmerging research has highlighted potential associations between micro-transaction use and problematic videogame and gambling behaviour. An increasingly prominent theory highlights that self-determined motivations and basic psychological needs may play crucial roles in the development of problematic videogame and gambling behaviour. However, literature discussing the role that micro-transaction use has in this relationship is scarce. The present study examined the role of micro-transactions in the relationship between self-determined motivations for gaming and gambling and problematic behaviour (internet gaming disorder and problem gambling severity). A sample of 370 participants (74.1% male, Mage = 28.24 years, SD = 7.88) answered questions related to their gaming and gambling motivations, basic psychological needs, micro-transaction use (i.e., type of micro-transaction, expenditure, and frequency of use), internet gaming disorder, and problem gambling. The present study used structural equation modelling methods to test relationships between these variables. The results indicated positive associations between extrinsic gaming and gambling motivations and frequency of micro-transaction use. Frequency of micro-transaction use (i) partially mediated the relationship between extrinsic gambling motivations and problem gambling severity, and (ii) fully mediated the relationship between externally regulated gaming motivations and problem gambling severity. Expenditure on micro-transactions and basic psychological needs were not found to be significant variables in the present study. Potential explanations for the findings, including a lack of self-esteem and a need to boost ego, social pressure, and rapid reward processes, are discussed. The implications and applications of the research are also discussed, focusing on limit setting and policy development focusing on frequency of micro-transaction use.
Investors’ reaction to banning IFRS use by domestic firms in alternative market
Authors: Białek-Jaworska Anna , Szymanek Paulina 
Published: November 2024

AbstractThis paper analyses the regulatory context, i.e., how IFRS preparers investing in Poland react to banning IFRS use by domestic firms in the alternative trading market (NewConnect) after six years of regulatory arbitrage. In other words, it studies their portfolio investment and foreign direct investment (FDI) outward sensitivity to the end of regulatory arbitrage opportunity given by the alternative market’s regulation in the country where accounting law limits IFRS use to regulated markets and business groups where the parent company uses IFRS. The contribution is built on the natural experiment of prohibition of domestic IFRS preparers issuing shares on the alternative (not-regulated and cheaper) trading market after 2012. The originality is delivered by implementing a de facto measure of IFRS adoption by foreign investors to identify a 69% growth rate of IFRS preparers investing in Polish firms in 2012 (317% growth of Swedish investors and 219% of Portuguese) that dropped to 8% in 2013 and 3% in 2018. Thus, we check whether investing decisions consider opportunities to gain funds or attract other investors and build trust through IPOs on the unregulated market dedicated to start-ups and engaged in R&D activity. We use difference-in-differences, GMM dynamic panel-data analysis with Arellano-Bond and Arellano-Bover/Blundel-Bond estimators for the Knowledge-Capital model on portfolio investment, outward FDI overall, and three FDI components based on debt, equity, and earning reinvestment in 2003–2019. We found that banning IFRS use by domestic firms in the alternative market discourages portfolio investments, debt-based FDI flows and FDI earnings reinvestment. Also, total FDI and equity-based FDI from countries with more IFRS preparers have been reduced since 2013 due to the IFRS ban for domestic firms.
Learning to Detect Novel Species with SAM in the Wild
Authors: Allabadi Garvita , Lucic Ana , Wang Yu-Xiong , Adve Vikram 
Published: November 2024

AbstractThis paper tackles the limitation of a closed-world object detection model that was trained on one species. The expectation for this model is that it will not generalize well to recognize the instances of new species if they were present in the incoming data stream. We propose a novel object detection framework for this open-world setting that is suitable for applications that monitor wildlife, ocean life, livestock, plant phenotype and crops that typically feature one species in the image. Our method leverages labeled samples from one species in combination with a novelty detection method and Segment Anything Model, a vision foundation model, to (1) identify the presence of new species in unlabeled images, (2) localize their instances, and (3) retrain the initial model with the localized novel class instances. The resulting integrated system assimilates and learns from unlabeled samples of the new classes while not “forgetting” the original species the model was trained on. We demonstrate our findings on two different domains, (1) wildlife detection and (2) plant detection. Our method achieves an AP of 56.2 (for 4 novel species) to 61.6 (for 1 novel species) for wildlife domain, without relying on any ground truth data in the background.
Properties of Al0.5CoCrFeNi2Ti High-Entropy Alloy System: From Gas-Atomized Powders to Atmospheric Plasma-Sprayed Coatings
Authors: Lin Tzu-Tang , Chen Shih-Hsun , Chiu Chun 
Published: November 2024

AbstractThe performance of the Al0.5CoCrFeNi2Ti HEA atmospheric plasma-sprayed coating was extended from characterizing the properties of its powder prepared via the gas atomization method. It was observed that the gas-atomized HEA powders possessed a solid solution BCC phase, while a major phase transformation to a FCC-L21 intermetallic phase occurred during the annealing process. The formation of the intermetallic phase resulted in an increase in average hardness from 6.28 to 7.64 GPa after annealing at 900 °C for 1 h. Afterward, HEA powders were applied in the atmospheric plasma spray technology. The phase constitution of Al0.5CoCrFeNi2Ti HEA coatings was investigated by varying powder size and applied current. It was observed that the smaller powder sizes prone to oxidation, whereas higher applied current facilitated the phase transformation from BCC to FCC phase. The nanoindentation test indicated distinct average microhardness values for the interlamellar oxide region, BCC unmelted particle and FCC phase lamellar region, which was measured at 12.35, 8.68 and 5.97 GPa, respectively. As a result, the adjustability of coating hardness was achieved by manipulating the relative phase ratio.
Preliminary Evidence of Sleep Improvements Following Psilocybin Administration, and their Involvement in Antidepressant Therapeutic Action
Authors: Reid Matthew J. , Kettner Hannes , Blanken Tessa F. , Weiss Brandon , Carhartt-Harris Robin 
Published: November 2024

Abstract
Purpose of the study
Psilocybin is a rapidly-emerging treatment for depression, yet its impact on sleep is not well understood. We sought to explore the literature on sleep and psilocybin use, and explore the topic using our own primary data.

Findings
Whilst clinical trials demonstrate large depressive symptom improvements, the impact of psilocybin on sleep quality or insomnia symptoms, has not been directly studied. Using our own preliminary-data we demonstrated that both depressive-symptoms and sleep-disturbances decreased significantly following psilocybin use, though sleep improvements were smaller compared to depressive symptoms. More severe sleep-disturbances at baseline were linked to lower probability of depression remission, underscoring a potential interaction between sleep and psilocybin’s efficacy.

Summary
Addressing sleep disturbances could enhance therapeutic outcomes in psilocybin-assisted therapy and could lead to more effective, personalized treatment-strategies. Future research should focus on populations with sleep disorders, and on examining causal-pathways of sleep physiology’s impact on psilocybin efficacy.
Understanding serine and glycine metabolism in cancer: a path towards precision medicine to improve patient’s outcomes
Authors: Sánchez-Castillo Anaís , Kampen Kim R. 
Published: November 2024

AbstractIn this perspective, we highlight and reflect on the current knowledge with respect to serine/glycine metabolism in cancer, therapeutic resistance, and precision medicine opportunities for therapeutic targeting and treatment follow-up. Cancer subtypes with high mortality rates include lung cancer and glioblastomas. In order to improve future therapeutic opportunities, patient stratification need to be performed to select patients that might benefit from adjuvant serine/glycine targeting compounds. In an effort to identify the group of patients for stratification purposes, we analyzed publicly available TCGA patient datasets to test associations between serine/glycine metabolism enzyme expression and important cancer drivers in lung cancer and glioblastoma. These patients presenting serine/glycine pathway overexpression might benefit from adjuvant sertraline treatment in the future.
Impact of tiger nut milk as a substitute for cow milk on the rheological, physiochemical, and organoleptic properties of functional ice cream
Authors: Ismail Hesham A. , Salama Wafaa M. , Ali Arwa A. , Awad Rezk A. 
Published: November 2024

AbstractTiger nuts are an excellent food choice due to their rich mineral, fiber, and antioxidant content. Tiger nut milk was replaced by 25, 50, 75, and 100% of cow’s milk in the ice cream mixture. The impact of substituting cow milk with tiger nut milk on the physicochemical, rheological, and organoleptic properties of ice cream was examined. Adding tiger nut milk in a combination resulted ice cream mixes with more fiber and antioxidants and a lower protein and ash levels compared to the control (100% cow milk). Ice cream with tiger nut milk was higher in Fe and Zn than that of control. Dynamic viscosity values of ice cream mixes with tiger nut milk were decreased with increasing values of the applied shear rate compared to the control. All functional ice cream formulations with tiger nut milk showed higher specific gravity and melting rate with lower overrun percentages than the control. Regarding taste and flavor, structure, texture, and melting in the mouth, there is no appreciable difference between the T25, T50, and control treatments. Therefore, cow’s milk can be replaced with tiger nut milk up to 50% in the ice cream industry to raise the nutritional value and functional properties.
Water desalination using atmospheric pressure plasma combined with thermal treatment
Authors: El-Hossary F. M. , Saber Ayman A. , Fawey Mohammed H. 
Published: November 2024

AbstractHerein, a novel method is presented for enhancing the thermal desalination process of saline water and seawater using atmospheric pressure plasma (APP). The effect of APP treatment combined with thermal heating (APP-TH) on the energy consumption, conductivity, and pH of seawater and saline water is investigated. Utilizing scanning electron microscopy and X-ray diffractometry, the evolution of the morphology, structure, and chemical composition of precipitated crystals is characterized. The APP-TH method reduces the energy consumption for desalination by 40.5% for saline water and by 52.82% for seawater when compared to the TH-only method. The pH value remains approximately unchanged, decreasing slightly for the saline water from 7.1 for untreated saline water to 7.05 after APP-TH treatment. However, after APP-TH treatment, the pH value of the seawater increased slightly, from 7 to 7.8. The total dissolved salts decreased after APP-TH treatment, lowering the conductivity of the saline water from 65,000 µS/cm to 160 µS/cm and the conductivity of the seawater from 58,200 µS/cm to 243 µS/cm. Moreover, the size of precipitated crystals from saline water is 31.47 nm after APP-TH treatment, compared to 55.59 nm after TH-only treatment. They also dropped from 41 nm to 39.5 nm for seawater. Compared with traditional approaches, this research proposes an optimistic solution to address global potable water scarcity issues.