bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of 80-kVp scan and raw data-based iterative reconstruction for reduced iodine load abdominal–pelvic CT in patients at risk of contrast-induced nephropathy referred for oncological assessment: effects on radiation dose, image quality and renal function
Authors: Nagayama Yasunori , Tanoue Shota , Tsuji Akinori , Urata Joji , Furusawa Mitsuhiro , Oda Seitaro , Nakaura Takeshi , Utsunomiya Daisuke , Yoshida Eri , Yoshida Morikatsu , Kidoh Masafumi , Tateishi Machiko , Yamashita Yasuyuki 
Published: February 2018

Objective:
To evaluate the image quality, radiation dose, and renal safety of contrast medium (CM)-reduced abdominal–pelvic CT combining 80-kVp and sinogram-affirmed iterative reconstruction (SAFIRE) in patients with renal dysfunction for oncological assessment.

Methods:
We included 45 patients with renal dysfunction (estimated glomerular filtration rate &lt;45 ml per min per 1.73 m2) who underwent reduced-CM abdominal–pelvic CT (360 mgI kg–1, 80-kVp, SAFIRE) for oncological assessment. Another 45 patients without renal dysfunction (estimated glomerular filtration rate &gt;60 ml per lmin per 1.73 m2) who underwent standard oncological abdominal–pelvic CT (600 mgI kg–1, 120-kVp, filtered-back projection) were included as controls. CT attenuation, image noise, and contrast-to-noise ratio (CNR) were compared. Two observers performed subjective image analysis on a 4-point scale. Size-specific dose estimate and renal function 1–3 months after CT were measured.

Results:
The size-specific dose estimate and iodine load of 80-kVp protocol were 32 and 41%,, respectively, lower than of 120-kVp protocol (p &lt; 0.01). CT attenuation and contrast-to-noise ratio of parenchymal organs and vessels in 80-kVp images were significantly better than those of 120-kVp images (p &lt; 0.05). There were no significant differences in quantitative or qualitative image noise or subjective overall quality (p &gt; 0.05). No significant kidney injury associated with CM administration was observed.

Conclusion:
80-kVp abdominal–pelvic CT with SAFIRE yields diagnostic image quality in oncology patients with renal dysfunction under substantially reduced iodine and radiation dose without renal safety concerns.

Advances in knowledge:
Using 80-kVp and SAFIRE allows for 40% iodine load and 32% radiation dose reduction for abdominal–pelvic CT without compromising image quality and renal function in oncology patients at risk of contrast-induced nephropathy.
shinySISPA: A web tool for defining sample groups using gene sets from multiple-omics data
Authors: Dwivedi Bhakti , Kowalski Jeanne 
Published: February 2018

As opposed to genome-wide testing of several hundreds of thousands of genes on very few samples, gene panels target as few as tens of genes and enable the simultaneous testing of many samples. For example, some cancer gene panels test for 50 genes that can affect tumor growth and potentially identify treatment options directed against the genetic mutation. The increasing popularity of gene panel testing has spurred the technological development of panels that test for diverse data types such as expression and mutation. Once samples are tested, there is the desire to examine clinical associations based on the panel and for this purpose, one would like to identify, among the samples tested, which show support for a molecular profile (e.g., presence of mutation with increased expression) versus those samples that do not among the genes tested. With user-specified molecular profile of interest, and gene panel data matrices (e.g., gene expression, variants, etc.) that define the profile, shinySISPA (Sample Integrated Set Profile Analysis) is a web-based shiny tool to define two sample groups with and without profile support based on our previously published method from which clinical associations may be readily examined. The shinySISPA can be accessed from http://shinygispa.winship.emory.edu/shinySISPA/.
Real Options Models for Proactive Uncertainty-Reducing Mitigations and Applications in Cybersecurity Investment Decision Making
Authors: Benaroch Michel 
Published: February 2018

Managerial flexibility, or real options, embedded in information technology (IT) investments allows resolving uncertainty not only by passively waiting for new information to arrive during deferral but also by proactively deploying mitigations. Classic real options models fail to account for the value of proactive uncertainty-reducing mitigations, since they assume that uncertainty is fixed or follows a continuous, time-dependent dynamics. We present adaptations of these models that address this shortcoming. In our models, zero or more mitigations can be applied in varying sequences, mitigations have impulse-type effects on uncertainty reduction, and mitigations’ effects can be complementary, substitutive, or synergetic. These traits make the value of mitigations path dependent and conditional on the uncertainty-reduction ability of earlier deployed mitigations. We operationalize the effects of mitigations in the IT and cybersecurity investment contexts. We also apply the adapted models to a real-world cybersecurity investment case from a Japanese company. Investments in multiple cybersecurity mitigations are typically treated as having a multiplicative effect that leads to overinvestment in mitigations. Our models avoid this problem, permitting to lower cybersecurity costs without compromising on loss prevention. More generally, our models allow implementing the real options logic more fully by supporting both passive and proactive IT investment risk management.The online appendix is available at https://doi.org/10.1287/isre.2017.0714 .
Lithuanian folk ensembles as bonding social capital: Perspectives on participatory music-making in Vilnius
Authors: Bartolome Sarah J. 
Published: February 2018

Abstract
The purpose of this study was to examine the culture of four Lithuanian folk ensembles with particular attention to the perceived values and benefits for participants and the perceived functions of the ensembles in local and national communities. Based on five months of ethnographic fieldwork in Vilnius, findings suggest a wide range of benefits associated with participation that vary across generations. Folk ensembles emerged as critical to the preservation and dissemination of a living body of folk culture and also serve to cultivate a sense of Lithuanian identity among members. Findings are examined using a social capital framework and the notion of Lithuanian folk ensemble as generators of flexible bonding social capital is forwarded.
Singing and spirituality in a South African male voice group
Authors: Joseph Dawn , Page-Shipp Roy , Niekerk Caroline van 
Published: February 2018

Abstract
Since the mid 1970s, a group of twelve business and professional members of a male singing group have continued singing together in Pretoria, South Africa. These singers were interviewed as part of a project on spirituality and well-being: music in the community. From the interview data, two overarching themes emerged, membership benefits and spiritual connections; these are discussed in this research project. Members’ views of benefits related mainly to fulfilment of personal, including musical, needs, although all were gratified that their singing provided enjoyment to community audiences and benefits to disadvantaged communities, mainly from ticket sale proceeds. Most saw an association between singing and the spiritual, but only a minority identified a religious connotation, the remainder relating to nonreligious factors such as the ‘human spirit’. A deep sense of commitment and a love of music impacts positively on social engagement, benefiting and enhancing quality of life for the group members.
Listen to a Songbird sing: Musicians, creativity and the paediatric hospital setting
Authors: Hawley Ros 
Published: February 2018

Abstract
Music making in a paediatric hospital offers new pathways to communication. Children become the leaders of musical interaction, as musicians carefully observe moods, emotions and the smallest of responses in order to be able to ‘listen’ to and respond to a child. Opportunities for music-making are created by the bedside and on the way to treatment. Medical professionals and families engage with live music and musicians, as a natural part of hospital life. Musical vocabulary is developed between musician and child patient to include music made with breath, mouth sounds, vocalization, hands and fingertips. Sense of time and space expand and contract in moments of music creation. Trust between musicians, patients and staff is gained through carefully paced musical interaction, ensuring a gradual exposure to musicians, live music and shared music-making. Songbirds, a two-year musicians’ residency in a children’s rehabilitation ward enabled children experiencing long-term hospitalization and their families to participate in regular music making sessions with myself and a colleague as part of their process of recovery. Many of the children were non-verbal and music making became an important element in supporting cognitive and social development and in reducing anxiety. In this case study of my practice as a musician working in a hospital I reflect on how the experience of making music with children informs and inspires processes of interaction and creativity, and how observations made during music making influence a musician’s reflection and consolidation of practice.
The performer-creator as collaborator in the music theatre industry: Creative agency versus professional agency
Authors: Walker Jessica 
Published: February 2018

Abstract
This article considers alternative creative, collaborative and professional possibilities for the classically trained singer in current music theatre practice. Through the lens of three self-created, professionally produced music theatre pieces, the article examines the agential development of the performer/creator, both in terms of how creative responsibility intersects with creative agency, and with regard to how external industry factors can influence and affect creative and professional agency.
Music theatre as a ‘fluctuating analytical protocol’ – Daniel Ott and Manos Tsangaris in conversation
Authors: Roesner David 
Published: February 2018

Abstract
The year 2016 marks the beginning of a new era in the history of one of the world’s leading festivals for new music theatre: the Munich Biennale. After Hans-Werner Henze (1988–94) and Peter Ruzicka (1996–2014), it will now be under the new joint artistic leadership of composers Daniel Ott and Manos Tsangaris. Their wide notion of what constitutes ‘music theatre’ and a radical rethinking of the conventions, hierarchies and chronologies of creating new original works forms an integral part of how they seek to innovate the festival and its artistic processes. This conversation seeks to explore their conceptual thinking for the festival and understanding of music theatre that drives them. The interview took place in November 2015, six months ahead of the launch of the Biennale 2016.
Modeling of Heat Transfer in Rotary Furnaces Using Finite Element Approach
Authors: Akinluwade K. J. , Ibitoye F. P. , Isadare D. A. , Adeoye M. O. , Adetunji A. R. 
Published: February 2018

Abstract
The pattern of heat flow in a 100-kg capacity rotary furnace was studied at transient state using finite element technique. The study combined volumetric analysis of combusting fuel with finite element analytical computation of heat transfer within the furnace hearth. A parabolic partial differential equation was used in combination with the results of volumetric analysis of combusting fuel, which is applicable to transient heat transfer. The results provide a finite element approach to computational modeling of medium-sized diesel-fired melting furnaces in the metallurgical industry.
Luminal A Breast Cancer and Molecular Assays: A Review
Authors: Gao Jennifer J. , Swain Sandra M. 
Published: February 2018

Abstract

Purpose
Chemotherapy has been the historical mainstay of treatment for patients with breast cancer, with immunohistochemical markers and tumor characteristics driving treatment decisions. The discovery of different intrinsic subtypes of breast cancer has advanced the understanding of breast cancer, with gene-based assays shedding further light on tumor behavior and response to treatment.

Design
This review focuses on the landscape of the luminal A subtype, its definition based on immunohistochemistry (IHC) and gene assays, the prognostic and predictive value of these assays, guideline recommendations, and treatment implications.

Results
Clinical studies of the prognostic value of gene-based and IHC-based assays in patients with luminal A-subtype breast cancers suggest a better prognosis for these patients compared with those with breast cancers of other subtypes.

Conclusion
In today's era of precision medicine, the best treatment regimen for patients with luminal A-subtype tumors is still undetermined, but available data raise the question whether chemotherapy can be omitted and endocrine therapy alone is sufficient for this patient population.

Implications for Practice
Immunohistochemical markers have traditionally guided treatment decisions in breast cancer. However, advances in gene-expression profiling and availability of gene-based assays have launched these newer tests into everyday clinical practice. Luminal A-subtype tumors are a unique subset that may have favorable tumor biology. Properly defining this tumor subtype is important and may identify a subset of patients for whom endocrine therapy alone is sufficient.
Kromozomal bozuklukların referans test ile doğrulanamadığı durumda iki aşamalı Bayes yöntemiyle performans ölçülerinin değerlendirilmesi
Authors: DERİCİ YILDIRIM Didem , TAŞDELEN Bahar , ÇAYAN Filiz , İZCİ AY Özlem , AY Mustafa Ertan 
Published: February 2018

Amaç: Kromozomal anormallik prevalansını ve diagnostik testlerin doğruluğunu tahmin etmek kromozomal bozukluklar altın Standard test ile doğrulanamadığı durumda ciddi bir problemdir. Bu çalışmanın amacı tanı testlerinin performasını ve kromozomal anomali prevalansını bayes analizi ile tahmin etmektir. Gereç ve Yöntem: Ağustos 2014 ve Ağustos 2015 tarihleri arasında Mersin Üniversitesi Hastanesi Kadın Hastalıkları ve Doğum polikliniğine başvurmuş gebeler çalışmaya dahil edilmiştir. Başvuran gebeler içerisinden, birinci trimester dönemde ultrasonografi ve ikili tarama test sonucu olan 1759 gebeye ait kayıtlardan yararlanılmıştır. İki Aşamalı Bayes yöntemi kullanılmıştır. İlk aşamada, bireyler hasta ve sağlıklı olarak sınıflandırılmaktadır. İkinci aşamada ise ilk aşamada hasta ya da sağlıklı olduğuna karar verilen bireylere altın standart test uygulanarak durumları doğrulanmaktadır. Bulgular: Önsel dağılım bilgisi olduğu durumda, birlikte duyarlılık ve seçicilik değerleri %77 ve %99 olarak tahmin edilmiştir. Önsel dağılım bilgisi olmadığı durumda ise, birlikte duyarlılık ve seçicilik değerleri %50 ve %97 olarak tahmin edilmiştir. Sapma Bilgi Ölçütü (DIC) ve Monte Carlo Hata (MC) değerleri birlikte incelendiğinde, önsel bilgi olduğu durumda modele uyum daha iyidir. Sonuç: Doğrulanamama problemi ile gebelikte uygulanan rutin tarama testleri için sıklıkla karşılaşılmaktadır. Tarama testlerinin doğruluğu bu yöntemden yararlanılarak daha doğru şekilde tahmin edilmektedir.
Üniversitede okuyan kız öğrencilerde depresyon prevalansı ve ilişkili faktörler
Authors: AÇIKGÖZ Ayla , DAYI Ayfer , BİNBAY Tolga 
Published: February 2018

maç: Bu çalışma, üniversitede okuyan kız öğrencilerde depresyon prevalansını belirlemek; bireysel, sosyodemografik ve sağlıkla ilişkili faktörlerin depresyonla ilişkisini araştırmak amacıyla yapılmıştır. Gereç ve Yöntem: Bu kesitsel araştırma 618 üniversite öğrencisi üzerinde yapılmıştır. Dokuz Eylül Üniversitesi’nin sağlık kampüsündeki Tıp Fakültesi, Hemşirelik Fakültesi, Fizik Tedavi ve Rehabilitasyon Yüksekokulu, Sağlık Hizmetleri Meslek Yüksekokulu’nun birinci sınıfında okuyan kız öğrenciler araştırma kapsamına alınmıştır. Öğrencilere öğrenci tanıtım formu ve Beck Depresyon Ölçeği (BDÖ) uygulanmıştır. Verilerin istatistiksel analizinde ki-kare testi, bağımsız gruplarda t testi, Mann-Whitney U testi, tek yönlü ANOVA testi ve lojistik regresyon analizi uygulanmıştır. Bulgular: Araştırma grubunun BDÖ skoru ortalaması 11.5±9.6 ve depresyon prevalansı (Beck Depresyon Ölçeği puanı ≥17) %25.6 olarak bulunmuştur. Anne babası ayrı olan, yurtta kalan, ekonomik algısı çok kötü ve kötü olan, kronik hastalığı olan, anemisi olan, sigara ve alkol kullanan, ruhsal/psikolojik sorun öyküsü olan öğrencilerde BDÖ puanı ortalaması ve depresyon prevalansı daha yüksek bulunmuştur. Sonuç: Öğrencilerin yaklaşık dörtte birinde depresyon vardır. Ekonomik düzey düşüklüğü, sağlıksız yaşam biçimi davranışları, kronik hastalık ve ruhsal sorun öyküsü, öğrencilerde depresyon prevalansını etkileyen en önemli faktörlerdir. Öğrencilere sigara, alkol, yanlış beslenme gibi sağlıksız yaşam biçimi davranışlarının azaltılmasına yönelik girişim çalışmaları yapılabilir. Üniversite öğrencilerine yönelik koruyucu ruh sağlığı programlarının geliştirilmesi ve uygulanması önerilir.
Chylous ascites: an unusual complication of peritoneal dialysis in an infant with congenital nephrotic syndrome
Authors: EKİNCİ Faruk , YILDIZDAŞ Rıza Dinçer , HOROZ Özden Özgür , MELEK Engin , PETMEZCİ Ercüment , TOLUNAY İlknur 
Published: February 2018

Chylous ascites is a rare but important non-infectious complication in patients undergoing peritoneal dialysis. A male infant of 1.5-month-old with congenital nephrotic syndrome admitted to our pediatric intensive care unit becasue of deterioration in general appearence, diffuse edematous appearance and respiratory distress. Peritoneal catheter insertion and peritoneal dialysis was performed in the 3rd day of hospitalization. Five days after peritoneal dialysis catheter insertion (on the 8th day of hospitalization) the peritoneal dialysis effluent had a milky appearance. The chemical analysis of the milky effluent showed characteristics of chylous ascites: triglycerides 468 mg/dl. The chylous ascites resolved at the 5th day of our treatment with a low fat diet with medium chain triglycerides and intravenous infusion of somatostatin analogue (octreotide) and the patient was transferred to the pediatric service for maintenance of the treatment.
A misleading cutaneous lesion for the surgeon: pyoderma gangrenosum
Authors: KORKMAZ SOLMAZ Güllü , ÇÖLOĞLU Harun , DURDU Murat , ERTAŞ Nilgün 
Published: February 2018

Pyoderma gangrenosum is a rare inflammatory skin disorder characterized by cutaneous papulo-pustules that evolve rapidly into large, painful, necrotic ulcers. These lesions are often initially diagnosed as wound infection and necrotizing fasciitis. Debridement, although the standard of care for wound infections, is paradoxically detrimental in pyoderma gangrenosum because of pathergy. Early diagnosis and treatment of pyoderma gangrenosum is very important because unnecessary debridement and associated morbidity can be prevented. Herein, we report a case with pyoderma gangrenosum mimicking necrotizing fasciitis.
Peningkatan Hasil Belajar Materi Keimanan melalui Pembelajaran Kooperatif Tipe TAI (Team Assisted Individualization)
Authors: Lestari Atik 
Published: February 2018

Penelitian ini bertujuan untuk mengetahui peningkatan hasil belajar mata pelajaran pendidikan agama islam materi iman kepada kitab-kitab Allah dengan model pembelajaran kooperatif tipe TAI (Team Assisted Individualization) kelas V SD Negeri 2 Kauman kemusu semester 1 tahun 2013/2014. Penelitian ini adalah penelitian tindakan kelas (PTK) yang menggunakan tiga siklus, masing-masing siklus memiliki empat tahap, yaitu perencanaan (planing), tindakan (acting), pengamatan (observing), dan refleksi (reflecting). Teknik analisis data yang digunakan dalam penelitian ini adalah deskriptif kualitatif dan deskriptif kuantitatif. Dalam penelitian ini terjadi peningkatan hasil belajar dari tolok ukur pencapaian KKM ≥70. Terjadi peningkatan ketuntasan hasil belajar siswa secara bertahap. Temuan penelitian menunjukkan bahwa penggunaan metode pembelajaran kooperatif tipe TAI yang tepat mampu meningkatkan hasil belajar. Hasil belajar siswa dapat meningkat, dilihat dari hasil tes formatif pada setiap siklus yaitu siklus I 27,78%, siklus II 72,22% dan siklus III 94,44% Mengacu pada hasil penelitian peneliti menyarankan kepada para guru atau calon guru untuk selalu meningkatkan inovasi pembelajarannya dengan menggunakan media, metode dan teknik yang bervariasi. Dengan demikian dapat disimpulkan bahwa penggunaan model pembelajaran kooperatif tipe TAI (Team Assisted Individualization) dapat meningkatkan hasil belajar siswa mata pelajaran PAI pada SD Negeri 2 Kauman Kecamatan Kemusu Kabupaten Boyolali Semester 1 tahun 2013/2014. This study aims to determine the learning outcome of Islamic religious education Faith in Holy Book material with cooperative learning method type of TAI (Team Assisted Individualization) in class V SD Negeri 2 Kauman Kemusu at the first semester year 2013/2014. It is a classroom action research. This study use three cycles, each cycle has four phases: planning, action, observation and reflection. Data analyses by descriptive qualitative and quantitative technique. In this study, there was an increase learning outcomes gradually to passing grade (KKM) ≥70. The findings indicate that the use of cooperative learning method, i.e. appropriate TAI, can improve learning outcomes. Students’ learning outcomes can be improved, judging from the results of formative tests at each cycle is the first cycle of 27.78%, 72.22% in second cycle and the third cycle 94.44% Referring to the results of the study, the researcher suggest to teachers or prospective teachers to improve learning by using varied media, methods and techniques. It can be concluded that the use of cooperative learning method type of TAI (Team Assisted Individualization) can improve student learning outcomes in PAI subject on SD Negeri 2 Kauman Kemusu Boyolali District in the first semester at the year of 2013/2014. Kata kunci: hasil belajar, Pendidikan Agama Islam, Team Assisted Individualization