bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of high venous ligation as an adjunct to endovenous therapy in the management of great saphenous vein incompetence: A systematic review and meta-analysis of randomized controlled trials
Authors: Aherne Thomas M , Medani Mekki , Sahebally Shaheel , Kheirelseid Elrasheid , Mulkern Edward , McDonnell Ciaran , Walsh Stewart R , O’Donohoe Martin K 
Published: January 2019

Background In recent years, endovenous intervention has emerged as a minimally invasive alternative to open venous surgery. However, endovenous intervention does not formally disconnect the deep and superficial venous systems and it is hypothesized that recurrence may be greater in the absence of high venous ligation. This study aims to compare the efficacy of a hybrid endovenous approach with adjuvant high venous ligation and standard operative intervention in the management of great saphenous incompetence. Methods In March 2018, Medline and Embase were systematically searched for relevant randomized controlled trials. All randomized controlled trials comparing a hybrid approach with standard operative intervention were included. Studies were required to include at least one pre-defined outcome. Data were extracted and assessed by two independent reviewers. Pooled risk ratios were calculated using a random effects model. Additional subgroup analyses were performed. Results Eight randomized controlled trials including 1244 patients were analysed. Pooled standardized data revealed no difference in overall recurrence (pooled RR = 1.00 [95% CI = 0.57, 1.77]), major operative morbidity (RR = 0.43 [95% CI = 0.06, 2.89]), or re-interventions (RR = 0.94 [95% CI = 0.12, 7.24]) for the hybrid group compared with standard operative intervention alone. Subgroup analysis revealed comparable short-, medium- and long-term recurrence rates between both cohorts. Furthermore, no difference in recurrence was identified when the hybrid approach was compared to open surgery alone (RR = 1.01 [95% CI = 0.63, 1.61]) or endovenous monotherapy (RR = 0.67 [95% CI = 0.04, 12.24]). Conclusion The use of a hybrid approach in the management of great saphenous incompetence appears to offer no recurrence, re-intervention or morbidity benefit when compared to standard operative intervention.
Graft protection of the liver by hypothermic machine perfusion involves recovery of graft regeneration in rats
Authors: Jia Jun-Jun , Xie Hai-Yang , Li Jian-Hui , He Yong , Jiang Li , He Ning , Zhou Lin , Wang Weilin , Zheng Shu-Sen 
Published: January 2019

Objective This study was performed to evaluate the impact and underlying mechanisms of hypothermic machine perfusion (HMP) on half-size liver graft regeneration. Methods Forty rats were randomly assigned to five groups: two in vitro groups (static cold storage [SCS] and HMP) and three in vivo groups (orthotopic liver transplantation, SCS, and HMP). Perfusates and plasma samples were collected for analysis of hepatic enzymes. Liver tissue was obtained for evaluation of histology, immunohistochemistry (Ki67 and proliferating cell nuclear antigen [PCNA]), and the regeneration rate. Cell cycle genes were analyzed by quantitative real-time polymerase chain reaction, and cyclin D1 and cyclin E1 were semiquantified by western blot. Results HMP improved histopathological outcomes and decreased hepatic enzyme release. The expression of Ki67 and PCNA demonstrated a greater proliferation activity in the HMP than SCS group, and the expression of almost all cell cycle genes was elevated following HMP. Western blot results showed higher protein levels of cyclin D1 and cyclin E1 in the HMP than SCS group. Conclusions Our findings suggest for the first time that half-size liver graft protection by HMP involves recovery of graft regeneration.
Effects of Estrogen-Deficient State on Rotator Cuff Healing
Authors: Tanaka Koji , Kanazawa Tomonoshin , Gotoh Masafumi , Tanesue Ryo , Nakamura Hidehiro , Ohzono Hiroki , Okawa Takahiro , Shiba Naoto 
Published: January 2019

Background: Rotator cuff retears after surgical repair are a concern, despite advances in operative techniques, but few studies have investigated the effects of the estrogen-deficient state on tendon-to-bone healing at the repair site. Purpose: We evaluated the effect of the estrogen-deficient state on tendon-to-bone healing after rotator cuff repair in an ovariectomized rat model. Study Design: Controlled laboratory study. Methods: Female Sprague Dawley rats underwent detachment and immediate repair of the supraspinatus tendon. Surgery was performed in 24 rats at 4.5 weeks of age 17 weeks after ovariectomy (OVX group) and in 24 age-matched control rats without ovariectomy (control group). Animals were sacrificed at 2, 4, 8, and 12 weeks after surgery for biomechanical and histological evaluations of reattachment. Bone mineral density (BMD) at the insertion site and cancellous bone in the humeral head was assessed by micro–computed tomography. Results: BMD was significantly lower both at the insertion site and in cancellous area in the OVX group than in the control group at weeks 2 to 12. Ultimate load to failure, ultimate stress, linear stiffness, and the Young modulus were significantly lower in the OVX group than in the control group at 2 and 4 weeks, but the difference was no longer significant at 8 and 12 weeks. At 2 and 4 weeks, relatively immature granulation tissue was observed in the OVX group compared with the control group. At 8 and 12 weeks after surgery, there were differences in the tendon-bone interface in the 2 groups: Direct insertion with well-established chondroid tissue was seen in the control group, and indirect insertion without chondroid tissue was seen in the OVX group. Consistently, the amount of chondroid tissue was greater and collagen organization was better in the control group than in the OVX group. Cells expressing cathepsin K were significantly more numerous both at the insertion site and in cancellous bone in the OVX group than in the control group. Conclusion: The estrogen-deficient state by ovariectomy, compared with control rats, led to decreased biomechanical properties and poor development of chondroid tissue that influenced the repair of the tendon insertion after surgery. Clinical Relevance: Agents that modulate bone metabolism might improve tendon-to-bone healing in patients with an estrogen-deficient state, such as postmenopausal women who undergo rotator cuff surgery.
Troponin I as an Early Biomarker of Cardiopulmonary Parameters Within the First 24 Hours After Nontraumatic Subarachnoid Hemorrhage in Intensive Care Unit Patients
Authors: Bender Michael , Stein Marco , Uhl Eberhard , Reinges Marcus H. T. 
Published: January 2019

Objective: The elevation of serum cardiac troponin I (TNI) in patients with nontraumatic subarachnoid hemorrhage (ntSAH) is a well-known phenomenon. However, the relation between elevated TNI and different cardiopulmonary parameters (CPs) within the first 24 hours after ntSAH is unknown. The present study was conducted to investigate the association between TNI and different CP in patients with ntSAH within the first 24 hours of intensive care unit (ICU) treatment. Patients and Methods: We retrospectively analyzed a consecutive group of 117 patients with ntSAH admitted to our emergency department between January 2008 and February 2017. Blood samples were taken to determine TNI values on admission. Demographic data, baseline Glasgow Coma Scale (GCS) score, World Federation of Neurosurgical Societies (WFNS) score, baseline Fisher grade (FG), norepinephrine application rate (NAR) in µg/kg/min, and inspiratory oxygen fraction (OF) were recorded within the first 24 hours. Results: An increased TNI value was found in 32 (27.4%) of 117 patients. There was a significant correlation between initial elevated TNI and a low WFNS score ( P = .007), a low GCS score ( P = .003) as well as a high OF ( P = <.001). The FG ( P = .27) and NAR ( P = .08) within the first 24 hours of ICU treatment did not show any significant correlation. Conclusions: In the present study, an increased TNI value was significantly associated with a low WFNS score and GCS score on admission. The TNI was a predictor of the need for a higher OF within the first 24 hours after ntSAH so that TNI could be an informative biomarker to improve ICU therapy.
In Strategy Simulations, Data Analysis Matters Most (More Than Number of Log Ins and More Than Time Spent Logged In)
Authors: Schmeller Rebecca 
Published: January 2019

Background. This data study examined the predictive power of student login activities (frequency, duration, opening reports) on simulation performance (seven Assurance of Learning scores), using Glo-Bus strategy simulation. Methods. The study used a sample of 351 students at a small, private Ohio university over four academic years (fall 2013 through spring 2017) to conduct regression analysis of three predictor variables (login data about reports, frequency, duration) and seven outcome variables (Assurance of Learning scores for finance, operations, marketing, HR, CSR, leadership, collaboration). Results. Opening reports was found to be more predictive of simulation performance than the other two login variables (frequency of logins, duration of logins). Discussion. In the literature, there were studies about strategy simulation login activity, but they did not address how Glo-Bus login activity types were related to Assurance of Learning scores. Some studies about strategy simulations called for more narrowly defined objectives and student accountability. This study supported that call – revealing that opening reports was more predictive of Assurance of Learning scores – suggesting students be held accountable for opening reports. Conclusions and Recommendations. Because this study found opening reports to be more predictive than other login activity, the software designers should promote report opening by making it a more direct and immediate aspect of the software and by including report analysis skills in the embedded quizzes. Additionally, instructor materials should include guidance on how to teach report use to Glo-Bus simulation students.
Should aspirin be suspended prior to robot-assisted radical prostatectomy? A systematic review and meta-analysis
Authors: Carneiro Arie , Cha Jonathan Doyun , Baccaglini Willy , Husain Fatima Z. , Wroclawski Marcelo Langer , Nunes-Silva Igor , Sanchez-Salas Rafael , Ingels Alexandre , Kayano Paulo Priante , Claros Oliver Rojas , Saviano Moran Natasha Kouvaleski , Sotelo René , Lemos Gustavo Caserta 
Published: January 2019

Background: Low-dose aspirin use has been correlated with an increased risk of bleeding and overall complications in surgical and invasive diagnostic procedures. In this review, our aim was to analyze the current literature on whether robot-assisted radical prostatectomy (RARP) is feasible and safe in patients taking low-dose aspirin perioperatively. Methods: A systematic review was performed identifying a total of 767 studies, published between January 2000 and September 2017, with five of these studies meeting the inclusion criteria for the meta-analysis, totalizing 1481 patients underwent RARP. Patients were divided into two groups: taking aspirin (group A) and those not taking aspirin (group B) perioperatively. Results: There were no significant differences between groups in the overall [group A 10.7% versus group B 15.7%, risk ratio (RR) 0.83; p = 0.45; I2 = 0%] or major complication rates (group A 1% versus group B 3%, RR 0.98; p = 0.98; I² = 0%), rate of cardiovascular events (group A 1.4% and group B 0.5%, RR 2.06; p = 0.24; I2 = 9%), blood loss (group A 278 ml versus group B 307 ml, SMD −0.12; p = 0.91; I2 = 96%), or hospital length of stay [group A 4 days (3–5) and group B 4 days (3–4), SMD −0.09; p = 0.52; I² = 0%]. There was a slightly higher blood-transfusion rate in group A (2.6%) versus group B (1.6%) (RR, 5.05; p = 0.04; I2 = 0%). Conclusion: Continued aspirin use in the perioperative period does not correlate with an increase in surgical morbidity, blood loss, or hospital length of stay. There was a slightly higher blood-transfusion rate in patients taking low-dose aspirin (group A) perioperatively.
Investigating the role of beliefs about emotions, emotional suppression and distress within a pain management programme for fibromyalgia
Authors: Bowers Hannah M , Pincus Tamar , Jones Gareth , Wroe Abigail L 
Published: January 2019

Introduction: This study aims to explore the relationships between beliefs about emotions, emotional suppression, distress and global impact (i.e. the extent to which a patient’s symptoms impact their life) in a longitudinal design with patients who are taking part in a pain management programme. Methods: A total of 40 participants with fibromyalgia took part in pain management programmes at multiple sites as part of their usual care in the National Health Service. Measures of beliefs about the unacceptability of experiencing and expressing emotions, emotional suppression, distress and global impact were completed before and after the programmes. Results: Beliefs about emotions significantly reduced following treatment, but emotional suppression did not. Changes in beliefs about emotion correlated with changes in emotional suppression. Changes in distress were related to changes in suppression and the relationship between global impact and beliefs about emotions was approaching significance. Conclusion: Emotional suppression and beliefs about emotions may play a role in the improvement in distress following treatment. However, future research should examine these variables as mediators of the effect of treatment compared to waitlist controls in a larger sample.
Approaches to Establish Extracardiac Total Cavopulmonary Connections in Animal Models—A Review
Authors: Granegger Marcus , Valencia Anna , Quandt Daniel , Dave Hitendu , Kretschmar Oliver , Hübler Michael , Schweiger Martin 
Published: January 2019

Background: Long-term survival of patients with a single ventricle palliated with a Fontan procedure is still limited. No curative treatment options are available. To investigate the pathophysiology and potential treatment options, such as mechanical circulatory support (MCS), appropriate large animal models are required. The aim of this review was to analyze all full-text manuscripts presenting approaches for an extracardiac total cavopulmonary connection (TCPC) animal model to identify the feasibility and limitations in the acute and chronic setting. Methods: A literature search was performed for full-text publications presenting large animal models with extracardiac TCPCs on Pubmed and Embase. Out of 454 reviewed papers, 23 manuscripts fulfilled the inclusion criteria. Surgical procedures were categorized and hemodynamic changes at the transition from the biventricular to the univentricular condition analyzed. Results: Surgical procedures varied especially regarding coronary venous flow handling and anatomic shape of the TCPC. In most studies (n = 14), the main pulmonary artery was clamped and the coronary venous flow redirected by additional surgical interventions. Only in five reports, the caval veins were connected to the right pulmonary artery to create a true TCPC shape, whereas in all others (n = 18), the veins were connected to the main pulmonary artery. An elevated pulmonary vascular resistance was identified as a limiting hemodynamic factor for TCPC completion in healthy animals. Conclusions: A variety of acute TCPC animal models were successfully established with and without MCS, reflecting the most important hemodynamic features of a Fontan circulation; however, chronic animal models were not reported.
Direct Medical Costs of Pediatric Congenital Heart Disease Surgery in a Belgian University Hospital
Authors: Willems Ruben , Tack Philip , François Katrien , Annemans Lieven 
Published: January 2019

Objectives: The recent trend to optimize the efficiency of health-care systems requires objective clinical and economic data. European data on the cost of surgical procedures to repair or palliate congenital heart disease in pediatric patients are lacking. Methods: A single-center study was conducted. Bootstrap analysis of variance and bootstrap independent t test assessed the excess direct medical costs associated with minor and major complications in nine surgical procedure types, from a health-care payer perspective. Generalized linear models with log-link function and inverse Gaussian family were used to determine associated covariates with the total hospitalization cost. Descriptive statistics show the repartition between out-of-pocket expenditures and reimbursed costs. Results: Four hundred thirty-seven patients were included. Mean hospitalization costs ranged from €11,106 (atrial septal defect repair) to €33,865 (Norwood operation). Operations with major complications yielded excess costs compared to operations with no complications, ranging from €7,105 (+65.2%) for a truncus arteriosus repair to €27,438 (+251.7%) for a tetralogy of Fallot repair. Differences in costs were limited between operations with minor versus no complications. Age at procedure, intensive care unit stay, procedure risk category, reintervention, and postoperative mechanical circulatory support were associated with higher total hospitalization costs. Out-of-pocket expenditures represented 6% of total hospitalization costs. Conclusion: Operations with major complications yield excess costs, compared to operations with minor or no complications. Cost data and attribution are important to improve clinical practice in a cost-effective manner. The health-care system benefits from strategies and technological advancements that have an impact on modifiable cost-affecting parameters.
Congenitally Corrected Transposition Presenting in the First Year of Life: Survival and Fate of the Systemic Right Ventricle
Authors: Smood Benjamin , Kirklin James K. , Pavnica Jozef , Tresler Margaret , Johnson Walter H. , Cleveland David C. , Mauchley David C. , Dabal Robert J. 
Published: January 2019

Introduction: Knowledge gaps exist in the life expectancy and functional outcome of patients with congenitally corrected transposition (ccTGA) presenting early in life, which is relevant in the evaluation of early anatomic repair. Methods: In a single-center analysis, 91 patients with ccTGA were identified over 25 years, of which 31 presented with biventricular anatomy in the first year of life and formed the study cohort. End points for analysis included survival, moderate or worse tricuspid valve regurgitation, and systemic right ventricle (RV) dysfunction. Median follow-up was 4.9 years (range: 7 days to 20 years). Results: Among 31 patients presenting in the first year of life, 9 (29%) never received cardiac surgery, while 22 (71%) underwent 36 cardiac operations. Overall freedom from moderate or severe systemic RV dysfunction was 75% at 10 years. Overall survival was 82% at 10 years. Surgical mortality was 5.6% (2/36). Among survivors with a systemic RV, 23 (100%) of 23 were Ross or NYHA class I or II at last follow-up. Conclusions: Congenitally corrected transposition presenting in the first year of life and maintaining a systemic RV can expect (1) long-term survival of more than 80% at 10 years, (2) low expected surgical mortality (overall 6%), and (3) 75% late freedom from major RV dysfunction at 10 years. Pending multi-institutional analyses, this experience with a systemic RV in ccTGA provides an initial benchmark for comparison when considering early elective anatomic correction.
lncRNA SNHG6 regulates EZH2 expression by sponging miR-26a/b and miR-214 in colorectal cancer
Authors: Xu Mu , Chen Xiaoxiang , Lin Kang , Zeng Kaixuan , Liu Xiangxiang , Xu Xueni , Pan Bei , Xu Tao , Sun Li , He Bangshun , Pan Yuqin , Sun Huiling , Wang Shukui 
Published: January 2019

Abstract
Background
Abnormal expression of long non-coding RNAs (lncRNAs) has been found in almost all human tumors, providing numerous potential diagnostic biomarkers, prognostic biomarkers, and therapeutic targets.

Methods
We analyzed RNA sequencing data to explore abnormally expressed lncRNAs in colorectal cancer (CRC). The functions of small nucleolar RNA host gene 6 (SNHG6) were investigated through in vitro and in vivo assays (CCK-8 assay, colony formation assay, flow cytometry assay, EdU assay, wound healing assay, transwell assay, and xenograft model). The mechanism of action of SNHG6 was explored through bioinformatics, RNA fluorescence in situ hybridization, luciferase reporter assay, RNA pull-down assay, chromatin immunoprecipitation assay, and RNA immunoprecipitation assay.

Results
We identified aberrantly expressed lncRNAs in CRC. We found that elevated SNHG6 expression was associated with poor prognosis and CRC progression. We also demonstrated that the high SNHG6 expression was partly due to DNA copy number gains and SP1 induction. Functional studies showed that SNHG6 promoted CRC cell growth, migration, and invasion both in vitro and in vivo. Mechanistically, we found that SNHG6 expressed predominantly in the cytoplasm. SNHG6 could interact with miR-26a, miR-26b, and miR-214 and regulate their common target EZH2.

Conclusions
Our study elucidated that SNHG6 acted as an oncogene in CRC, which might serve as a novel target for CRC diagnosis and therapy.
Embodied meaning: a systemic functional perspective on paralanguage
Authors: Martin J. R. , Zappavigna Michele 
Published: January 2019

AbstractThis paper develops a framework for analysing paralanguage, initially inspired by systemic functional linguistic (hereafter SFL) research on early child language development. A distinction is drawn between non-semiotic behaviour (somasis) and meaning (semiosis), and within semiosis between language and paralanguage (using the term paralanguage to refer to semiosis dependent on language and realised through both sound quality and body language, the latter including facial expression, gesture, posture and movement). Within paralanguage a distinction is drawn between sonovergent resources in sync with or in tune with the prosodic phonology of spoken language, and semovergent resources supporting the ideational, interpersonal and textual meaning resources of spoken language’s content plane. The paper closes with a brief discussion of the intermodal relations among language, paralanguage and other modalities of communication.
Recent Improvements in the Production of Solar Fuels: From CO2 Reduction to Water Splitting and Artificial Photosynthesis
Authors: Roy Nitish , Suzuki Norihiro , Terashima Chiaki , Fujishima Akira 
Published: January 2019

Abstract
This account deals with recent trends and challenges regarding photo(electro)chemical solar fuels produced by CO2 reduction and water splitting.
The CO2 reduction process is limited by product selectivity, catalyst stability, and its complex reaction mechanism. A variety of catalysts—including thermocatalysts, photocatalysts, electrocatalysts, and combinations of photo- and electrocatalysts—have been employed to facilitate selective and durable CO2 reduction. In addition, the roles of the supporting electrolyte, pH, reaction temperature, chemical environment, and catalyst surface chemistry in efficient CO2 reduction have been thoroughly studied in recent years.
Effective use of solar light is a significant part of realizing efficient solar-to-hydrogen conversion during the water splitting process, and so the response of photo(electro)systems to visible light is key. To this end, several strategies have been studied in detail, including band engineering of photocatalysts, photocatalytic systems that mimic natural photosynthesis, and the development of photoanodes and their combination with photovoltaic systems.
Here, we summarize recent developments surrounding the CO2-reduction and water-splitting reactions and progress towards achieving artificial photosynthesis.