bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insight of a Phase Compatible Surface Coating for Long‐Durable Li‐Rich Layered Oxide Cathode
Authors: Hu Sijiang , Li Yu , Chen Yuhua , Peng Jiming , Zhou Tengfei , Pang Wei Kong , Didier Christophe , Peterson Vanessa K. , Wang Hongqiang , Li Qingyu , Guo Zaiping 
Published: July 2019

AbstractLi‐rich layered oxides (LLOs) can deliver almost double the capacity of conventional electrode materials such as LiCoO2 and LiMn2O4; however, voltage fade and capacity degradation are major obstacles to the practical implementation of LLOs in high‐energy lithium‐ion batteries. Herein, hexagonal La0.8Sr0.2MnO3−y (LSM) is used as a protective and phase‐compatible surface layer to stabilize the Li‐rich layered Li1.2Ni0.13Co0.13Mn0.54O2 (LM) cathode material. The LSM is MnOM bonded at the LSM/LM interface and functions by preventing the migration of metal ions in the LM associated with capacity degradation as well as enhancing the electrical transfer and ionic conductivity at the interface. The LSM‐coated LM delivers an enhanced reversible capacity of 202 mAh g−1 at 1 C (260 mA g−1) with excellent cycling stability and rate capability (94% capacity retention after 200 cycles and 144 mAh g−1 at 5 C). This work demonstrates that interfacial bonding between coating and bulk material is a successful strategy for the modification of LLO electrodes for the next‐generation of high‐energy Li‐ion batteries.
Sinonasal quality‐of‐life outcomes after endoscopic endonasal skull base surgery
Authors: Bhenswala Prashant N. , Schlosser Rodney J. , Nguyen Shaun A. , Munawar Suqrat , Rowan Nicholas R. 
Published: July 2019

BackgroundThere are substantial gaps in our understanding of the influence of the endoscopic endonasal approach (EEA) for endoscopic skull base surgery on sinonasal‐specific quality of life (QOL) as well as the instruments available for assessment. Our primary objective in this study was to characterize postoperative changes in sinonasal QOL, specifically using the 22‐item Sino‐Nasal Outcome Test (SNOT‐22), with a secondary objective of delineating weaknesses in our current understanding of patient symptomatology after EEA for skull base surgery.MethodsA comprehensive literature review was conducted using PubMed, CINAHL, Cochrane Library, and SCOPUS for studies reporting SNOT‐22 data pre‐ and postoperatively in patients who underwent EEA for skull base pathologies. Studies were limited to patients ≥18 years of age and excluded patients diagnosed with chronic rhinosinusitis (CRS).ResultsNineteen unique studies with 27 separate data sets and a total of 1025 patients were used in this meta‐analysis. Overall SNOT‐22 scores statistically improved at the 6‐month (p = 0.0009) and 1‐year (p = 0.002) time‐points. Patients with preoperative SNOT‐22 scores ≥20 achieved postoperative improvements at 12‐week (p < 0.00001), 6‐month (p < 0.0001), 1‐year (p < 0.00001), and long‐term follow‐up (p < 0.0001). Patients with preoperative SNOT‐22 scores <20 remained stable and did not worsen postoperatively.ConclusionPatients undergoing EEA for skull base pathologies who have impaired sinonasal QOL preoperatively demonstrated significant postoperative QOL improvements. Those patients with relatively normal preoperative sinonasal QOL remained asymptomatic postoperatively. This study supports the need for development of a contemporary disease‐ and approach‐specific, validated QOL instrument for skull base pathologies.
The Dual‐Stereocontrol Mechanism: Heteroselective Polymerization of rac‐Lactide and Syndioselective Polymerization of meso‐Lactide by Chiral Aluminum Salan Catalysts
Authors: Hador Rami , Botta Antonio , Venditto Vincenzo , Lipstman Sophia , Goldberg Israel , Kol Moshe 
Published: July 2019

AbstractWe describe alkoxo‐aluminum catalysts of chiral bipyrrolidine‐based salan ligands that follow the dual‐stereocontrol mechanism wherein a given combination of stereogeneities at the metal site and the proximal center of the last inserted lactidyl (“match”) is active towards lactide having a proximal stereogenic center of the opposite configuration, while the diastereomeric combination of stereogeneities (“mismatch”) is inactive towards any lactide. Polymerization of rac‐LA by the enantiomerically pure catalysts was sluggish and gave stereoirregular poly(lactic acid) (PLA) because selective insertion to a match diastereomer gives a mismatch diastereomer. The racemic catalysts showed higher activity and led to highly heterotactic PLA following polymeryl exchange between two mismatched catalyst enantiomers. A succession of match diastereomers in selective meso‐LA insertions led to syndiotactic PLAs reaching a syndiotacticity degree of α=0.96. This polymer featured a Tm of 153 °C matching the highest reported value, and the highest crystallinity (ΔHm=56 J g−1) ever reported for syndiotactic PLA.
Ligand‐Enabled PdII‐Catalyzed Iterative γ‐C(sp3)−H Arylation of Free Aliphatic Acid
Authors: Dolui Pravas , Das Jayabrata , Chandrashekar Hediyala B. , Anjana S. S. , Maiti Debabrata 
Published: July 2019

AbstractC−H functionalization of aliphatic carboxylic acids without attaching exogenous auxiliary has been so far limited at the proximal β‐position. In this work, we demonstrate a ligand enabled palladium catalyzed first regioselective distal γ‐C(sp3)−H functionalization of aliphatic carboxylic acids without incorporating an exogenous directing group. Aryl iodides containing versatile functional groups including complex organic molecules are well tolerated with good to excellent yields during the γ‐C(sp3)−H arylation reaction. Interestingly, weak coordination of carboxylate group can be further extended for sequential hetero di‐arylation. Application of the protocol has been showcased by synthesizing substituted α‐tetralone. Mechanistic investigations have been carried out to shed light on the reaction pathway.
Van der Waals Heterostructured MOF‐on‐MOF Thin Films: Cascading Functionality to Realize Advanced Chemiresistive Sensing
Authors: Yao Ming‐Shui , Xiu Jing‐Wei , Huang Qing‐Qing , Li Wen‐Hua , Wu Wei‐Wei , Wu Ai‐Qian , Cao Lin‐An , Deng Wei‐Hua , Wang Guan‐E , Xu Gang 
Published: July 2019

AbstractHeterostructured metal—organic framework (MOF)‐on‐MOF thin films have the potential to cascade the various properties of different MOF layers in a sequence to produce functions that cannot be achieved by single MOF layers. An integration method that relies on van der Waals interactions, and which overcomes the lattice‐matching limits of reported methods, has been developed. The method deposits molecular sieving Cu‐TCPP (TCPP=5,10,15,20‐tetrakis(4‐carboxyphenyl)porphyrin) layers onto semiconductive Cu‐HHTP (HHTP=2,3,6,7,10,11‐hexahydrotriphenylene) layers to obtain highly oriented MOF‐on‐MOF thin films. For the first time, the properties in different MOF layers were cascaded in sequence to synergistically produce an enhanced device function. Cu‐TCPP‐on‐Cu‐HHTP demonstrated excellent selectivity and the highest response to benzene of the reported recoverable chemiresistive sensing materials that are active at room temperature. This method allows integration of MOFs with cascading properties into advanced functional materials.
Pressure‐Induced Multiphoton Excited Fluorochromic Metal–Organic Frameworks for Improving MPEF Properties
Authors: Chen Cheng‐Xia , Yin Shao‐Yun , Wei Zhang‐Wen , Qiu Qian‐Feng , Zhu Neng‐Xiu , Fan Ya‐Nan , Pan Mei , Su Cheng‐Yong 
Published: July 2019

AbstractIn multiphoton excited fluorescence (MPEF), high‐energy upconversion emission is obtained from low‐energy excitation by absorbance of two or more photons simultaneously. In a pressure‐induced fluorochromic process, the emission energy is switched by outer pressure stimuli. Now, five metal–organic frameworks containing the same ligand with simultaneous multiphoton absorption and pressure‐induced fluorochromic attributes were studied. One‐, two‐, and three‐photon excited fluorescence (1/2/3PEF) can be achieved in the frameworks, which exhibit pressure‐induced blue‐to‐yellow fluorochromism. The performances are closely dependent with the topologies, flexibilities, and packing states of the frameworks and chromophores therein. The multiphoton upconversion performance can be intensified by pressure‐related structural contraction. Over ten‐fold increment in the 2PA active cross‐section up to 2217 GM is achieved in pressed LIFM‐114 compared with the 210 GM for pristine sample at 780 nm.
C3‐Symmetric Assemblies from Trigonal Polycarbene Ligands and MI Ions for the Synthesis of Three‐Dimensional Polyimidazolium Cations
Authors: Zhang Le , Das Rajorshi , Li Chang‐Tao , Wang Yao‐Yu , Hahn F. Ekkehardt , Hua Kai , Sun Li‐Ying , Han Ying‐Feng 
Published: July 2019

AbstractMetallosupramolecular poly‐NHC‐metal assemblies were prepared from trigonal hexakis (H6‐1 a(PF6)6 and H6‐1 b(PF6)6) or nonakis (H9‐3(BF4)9) imidazolium salts and Ag2O. Complexes [Ag6(1 a)2](PF6)6 and [Ag6(1 b)2](PF6)6 are built from six Ag+ ions sandwiched between two trigonal hexacarbene ligands with an inner and an outer NHC donor in each of the three ligand arms. The metal atoms are arranged in two triangles. The hexakis‐NHC ligands bear cinnamic ester groups at the outlying NHC donors, used in postsynthetic [2+2] cycloaddition reactions linking two hexakis‐NHC ligands by three cyclobutane units to give complexes [Ag6(2 a)](PF6)6 and [Ag6(2 b)](PF6)6 bearing a dodecacarbene ligand. From the related nonakisimidazolium salt H9‐3(BF4)9, complex [Ag9(4)](BF4)9 bearing an octadecacarbene ligand was obtained. Removal of the template metals yielded very large, stable, polyimidazolium cations with 12 or 18 internal imidazolium groups.
Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human‐ and Animal‐Pathogenic Burkholderia Species
Authors: Trottmann Felix , Franke Jakob , Richter Ingrid , Ishida Keishi , Cyrulies Michael , Dahse Hans‐Martin , Regestein Lars , Hertweck Christian 
Published: July 2019

AbstractBurkholderia species such as B. mallei and B. pseudomallei are bacterial pathogens causing fatal infections in humans and animals (glanders and melioidosis), yet knowledge on their virulence factors is limited. While pathogenic effects have been linked to a highly conserved gene locus (bur/mal) in the B. mallei group, the metabolite associated to the encoded polyketide synthase, burkholderic acid (syn. malleilactone), could not explain the observed phenotypes. By metabolic profiling and molecular network analyses of the model organism B. thailandensis, the primary products of the cryptic pathway were identified as unusual cyclopropanol‐substituted polyketides. First, sulfomalleicyprols were identified as inactive precursors of burkholderic acid. Furthermore, a highly reactive upstream metabolite, malleicyprol, was discovered and obtained in two stabilized forms. Cell‐based assays and a nematode infection model showed that the rare natural product confers cytotoxicity and virulence.
Site‐Selective Functionalization of (sp3)C−H Bonds Catalyzed by Artificial Metalloenzymes Containing an Iridium‐Porphyrin Cofactor
Authors: Gu Yang , Natoli Sean N. , Liu Zhennan , Clark Douglas S. , Hartwig John F. 
Published: July 2019

AbstractThe selective functionalization of one C−H bond over others in nearly identical steric and electronic environments can facilitate the construction of complex molecules. We report site‐selective functionalizations of C−H bonds, differentiated solely by remote substituents, catalyzed by artificial metalloenzymes (ArMs) that are generated from the combination of an evolvable P450 scaffold and an iridium‐porphyrin cofactor. The generated systems catalyze the insertion of carbenes into the C−H bonds of a range of phthalan derivatives containing substituents that render the two methylene positions in each phthalan inequivalent. These reactions occur with site‐selectivity ratios of up to 17.8:1 and, in most cases, with pairs of enzyme mutants that preferentially form each of the two constitutional isomers. This study demonstrates the potential of abiotic reactions catalyzed by metalloenzymes to functionalize C−H bonds with site selectivity that is difficult to achieve with small‐molecule catalysts.
Preparing Perinatal Nurses for Obstetric OR Emergencies by Using Simulations
Authors: Stokes Tanesha L. , Koslan Garrett 
Published: July 2019

AbstractA cesarean hysterectomy (CH) is an emergency procedure that can save a woman's life in the event of postpartum hemorrhaging. If the CH is anticipated, it can take place in the general OR; however, more complex patients with multiple comorbidities are undergoing cesarean deliveries, resulting in unanticipated CHs and emergent procedures occurring in the obstetric OR. Many perinatal nurses believe they are not properly trained to provide the level of perioperative care required during a CH. Perinatal nurse leaders implemented a perinatal perioperative simulation program to address this knowledge gap. Feedback from perinatal nurses after completing the simulation revealed they gained a comprehensive understanding of the flow of the procedure and the instrumentation needed to perform it. The simulation also improved communication and leadership skills in the obstetric OR. Simulations may help perinatal nurses provide safer, higher quality care when a delivery develops into a high‐risk operative procedure.
Determinants of pro‐environmental behavior and environmentally conscious consumer behavior: An empirical investigation from emerging market
Authors: Kautish Pradeep , Sharma Rajesh 
Published: July 2019

AbstractGiven the due importance of environmentally conscious consumer behavior (ECCB) and willingness to be environmentally friendly (WEF), the aim of this paper is to study the relationships between the determinants of pro‐environmental behavior (e.g., perceived behavioral control, environmental knowledge, environmental concern, and perceived environmental consequences), with ECCB and WEF. The proposed theoretical model is grounded in marketing literature, extends the theory of planned behavior, and empirically tested in the Indian market. A survey with questionnaire was administered to gather data from 510 respondents from the state capital of the country. Structural equation modeling was used to test the hypotheses; the results confirm adequate support for the theory of planned behavior and proposed theoretical model. In addition, ECCB found to be significantly influenced by the consumers' environmental knowledge, and perceived environmental consequences, and environmental concern was significantly related to WEF. The study implies that green marketers should direct their marketing efforts towards integrating these four pro‐environmental behavior determinants in order to facilitate the ECCB and WEF for green products. For promoting the ECCB, green marketers should strengthen environmental knowledge and perceived environmental consequences to target consumers, and for augmenting the WEF, they should improve the environment concern among consumers. This study contributes to the mainstream literature by ascertaining the distinctive impact of the four noteworthy determinants of pro‐environmental behavior on ECCB and WEF in emerging markets.
Biogenic synthesis of silver nanoparticles using Brazilian propolis
Authors: Barbosa Valcilaine T. , Souza Joyelanne K. C. , Alvino Valter , Meneghetti Mario R. , Florez‐Rodriguez Pedro P. , Moreira Rui E. , Paulino Gustavo V. B. , Landell Melissa F. , Basílio‐Júnior Irinaldo D. , do Nascimento Ticiano G. , Grillo Luciano A. M. , Dornelas Camila B. 
Published: July 2019

AbstractBiological methods have been used to synthesize silver nanoparticles through materials such as bacteria, fungi, plants, and propolis due to their reducing properties, stabilizer role and environmentally friendly characteristic. Considering the antimicrobial activity of propolis as well as the broad‐spectrum antibacterial effects of silver nanoparticles, this study aim to describe the use of Brazilian propolis to synthesize silver nanoparticles (AgNP‐P) and investigate its antimicrobial activity. The synthesis was optimized by factorial design, choosing the best conditions for smaller size particles. AgNP‐P demonstrated a maximum absorbance at 412 nm in ultraviolet‐visible spectra, which indicated a spherical format and its formation. Dynamic light scattering demonstrated a hydrodynamic size of 109 nm and polydispersity index less than 0.3, showing a good size distribution and stability. After its purification via centrifugation, microscopy analysis corroborates the format and showed the presence of propolis around silver nanoparticle. X‐ray diffraction peaks were attributed to the main planes of the metallic silver crystalline structure; meanwhile infrared spectroscopy demonstrated the main groups responsible for silver reduction, represented by ∼22% of AgNP‐P indicates by thermal analysis. Our product revealed an important antimicrobial activity indicating a synergism between propolis and silver nanoparticles as expected and promising to be an effective antimicrobial product to be used in infections.
Educational guidance process integrating opinion mining
Authors: Lazib Samia , Bouarab‐Dahmani Farida , Haddadi Lynda 
Published: July 2019

AbstractOpinion mining is a fast‐developing field of study with numerous applications. It raises economic and political interests, especially in decision‐making processes. In this paper, we are interested in educational opinion mining. We propose an educational guidance process that aims to improve university orientation after the secondary school cycle. Unlike the ordinary orientation processes, our process integrates the opinions of pupil, parents, and teachers, collected periodically. These opinions ​​are treated to sort out the studies’ domains in a positive polarity order. An orientation score is then calculated based on these opinions, the student's aptitudes and the continuous evaluation marks to guide pupils toward the most favourable discipline. The experimentations conducted on a sample of pupils (300) give a better convergence to the pupils’ explicit choices using our proposal with a κ coefficient of 0.71, against 0.29 using only marks.
Three‐year follow‐up results from phase II studies of nivolumab in Japanese patients with previously treated advanced non‐small cell lung cancer: Pooled analysis of ONO‐4538‐05 and ONO‐4538‐06 studies
Authors: Horinouchi Hidehito , Nishio Makoto , Hida Toyoaki , Nakagawa Kazuhiko , Sakai Hiroshi , Nogami Naoyuki , Atagi Shinji , Takahashi Toshiaki , Saka Hideo , Takenoyama Mitsuhiro , Katakami Nobuyuki , Tanaka Hiroshi , Takeda Koji , Satouchi Miyako , Isobe Hiroshi , Maemondo Makoto , Goto Koichi , Hirashima Tomonori , Minato Koichi , Sumiyoshi Naoki , Tamura Tomohide 
Published: July 2019

AbstractBackgroundNivolumab is a programmed cell death 1 (PD‐1) receptor inhibitor antibody that enhances immune system antitumor activity. It is associated with longer overall survival (OS) than the standard treatment of docetaxel in patients with previously treated advanced squamous (SQ) and non‐squamous (non‐SQ) non‐small cell lung cancer (NSCLC). We previously conducted two phase II studies of nivolumab in Japanese patients with SQ (ONO‐4538‐05) and non‐SQ (ONO‐4538‐06) NSCLC, showing overall response rates (ORRs) (95% CI) of 25.7% (14.2‐42.1) and 22.4% (14.5‐32.9), respectively, with acceptable toxicity. In this analysis, we more precisely estimated the long‐term safety and efficacy in patients with SQ and non‐SQ NSCLC by pooling data from these two trials.MethodsSQ (N = 35) and non‐SQ (N = 76) NSCLC patients received nivolumab (3 mg/kg, every 2 weeks) until progression or discontinuation. OS was estimated using the Kaplan–Meier method. A pooled analysis of SQ and non‐SQ patients was also performed.ResultsIn SQ NSCLC patients, the median OS (95% CI) was 16.3 months (12.4‐25.2), and the estimated 1‐year, 2‐year, and 3‐year survival rates were 71.4% (53.4‐83.5), 37.1% (21.6‐52.7), and 20.0% (8.8‐34.4), respectively. In non‐SQ NSCLC patients, median OS was 17.1 months (13.3‐23.0), and the estimated 1‐, 2‐, and 3‐year survival rates were 68.0% (56.2‐77.3), 37.4% (26.5‐48.1), and 31.9% (21.7‐42.5), respectively. When SQ NSCLC and non‐SQ NSCLC data were pooled, the median OS was 17.1 months (14.2‐20.6), and the estimated 1‐, 2‐, and 3‐year survival rates were 69.1% (59.6‐76.8), 37.3% (28.3‐46.2), and 28.1% (20.0‐36.7), respectively. Twenty (76.9%) of 26 responders lived for 3 or more years. Nivolumab was well tolerated and no new safety signals were found.ConclusionTreatment with nivolumab improved long‐term survival and was well tolerated in patients with SQ and non‐SQ NSCLC.Trial registrationJapicCTI‐132072; JapicCTI‐132073.
Nivolumab‐induced celiac‐like enteropathy in patient with metastatic renal cell carcinoma: Case report and review of the literature
Authors: Duval Lucie , Habes Sarah , Chatellier Thierry , Guerzider Pascale , Bossard Céline , Masliah Claude , Archambeaud Isabelle , Touchefeu Yann , Matysiak‐Budnik Tamara 
Published: July 2019

AbstractNivolumab may induce severe celiac‐like enteropathy, that may appear very rapidly, after only two injections of nivolumab, and may be successfully treated with corticosteroids. This observation underlines the importance of histological analysis of duodenal biopsies and the necessity to rule out a real celiac disease in patients with nivolumab‐induced diarrhea.
Development of Highly Selective Support for CO Hydrogenation to Light Olefins with Partially Passivated Iron Catalysts
Authors: Xing Yu , Jia Gaopeng , Liu Zhenxin , Fang Shaoming , Zhao Chenxi , Guo Xuehui , Suib Steven L. 
Published: July 2019

AbstractThe front cover artwork for Issue 14/2019 is provided by researchers from Yu Xing, Zhenxin Liu and co‐workers at the Zhengzhou University of Light Industry (P. R. China) and the University of Connecticut (USA). The image shows that light olefins (ethylene, propylene and butylene) may be selectively generated through conversion of syngas over an iron catalyst with a partially passivated Al–O–Zn support. See the Full Paper itself at https://doi.org/10.1002/cctc.201900023.
A new incipient fault monitoring method based on modified principal component analysis
Authors: Yang Yinghua , Wang Xiulong , Liu Xiaozhi 
Published: July 2019

AbstractA novel multivariate statistical process monitoring (MSPM) method based on modified principal component analysis (PCA) is proposed to solve the low detection rate problem of incipient fault. In this modified PCA, on the basis of normal PCA model, the columns of loading matrix are reordered by mutual information between different statistic component matrices and training data. Then, instead of cumulative percent variance criterion, the principal component subspace is selected according to the largest mutual information. The selected PC subspace can maximally reflect fault characteristics into a new statistical index. Besides, a detection index based on the sliding average control chart statistic is proposed, which eliminates the effect of noise by proper averaging of the most recent samples, greatly improving the ability and accuracy of fault detection. The case study of a numerical simulation and Tennessee Eastman process shows that the proposed method can effectively detect incipient fault.