bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification crisis: a fauna-wide estimate of biodiversity expertise shows massive decline in a Central European country
Authors: Páll-Gergely Barna , Krell Frank-Thorsten , Ábrahám Levente , Bajomi Bálint , Balog Luca Eszter , Boda Pál , Csuzdi Csaba , Dányi László , Fehér Zoltán , Hornok Sándor , Horváth Adrienn , Kóbor Péter , Koczor Sándor , Kontschán Jenő , Kovács Péter , Kovács Tibor , Lukátsi Márk , Majoros Gábor , Murányi Dávid , Németh Tamás , Pernecker Bálint , Puskás Gellért , Rózsa Lajos , Soltész Zoltán , Szita Éva , Szűts Tamás , Tóth Balázs , Tőke Andrea , Vas Zoltán , Zsuga Katalin , Zsupos Vivien , Csabai Zoltán , Móra Arnold 
Published: November 2024

AbstractExpertise in biodiversity research (taxonomy, faunistics, conservation with taxonomic background) appears to decline worldwide. While the “taxonomic impediment” is discussed extensively in the literature, much fewer papers focus on the identification crisis, i.e., the decreasing number of experts who can identify species, and the decline of species-based biodiversity research. As a test case to explore the gravity of the identification crisis, we chose Hungary, a Central European country with a strong history of comprehensive taxonomic expertise and research output. We set out to answer two main questions. (1) What proportion of the Hungarian fauna could currently be identified by Hungarian experts, and what factors determine which groups are covered; and (2) what are the trends of biodiversity research in Hungary, and what are the underlying reasons for these trends? We show that Hungary lacks active biodiversity experts for almost half of the nearly 36,000 animal species recorded in the country, and more than a quarter of the fauna have only one or two active experts available. We also show that faunistic research experienced a golden era between ca. 1990 and 2010. Since then, however, there has been a strong decline, with the number of active experts and published papers decreased to a level like that of the 1970s. Multiple factors are identified causing this trend, such as increased pressure to publish in high impact journals and increasing administrative duties of professional scientists. The next generation of biodiversity experts needs to be fluent in modern techniques and publication strategies but also maintain robust morphology-based knowledge to be equipped for identification tasks of difficult taxa. Despite being disadvantaged by exclusive application of citation-based evaluation, we do need more positions and focused grants for biodiversity researchers to maintain the country’s knowledge base and to avoid being increasingly dependent on—equally declining—foreign expertise.
Synergistic Epistasis and Systems Biology Approaches to Uncover a Pharmacogenomic Map Linked to Pain, Anti-Inflammatory and Immunomodulating Agents (PAIma) in a Healthy Cohort
Authors: Sharafshah Alireza , Motovali-Bashi Majid , Keshavarz Parvaneh , Blum Kenneth 
Published: November 2024

AbstractThe global public health addiction crisis has been stark, with over 932,400 deaths in the USA and Canada from opioid overdose since 1999–2020, surpassing the mortality rates at the top of the HIV/AIDS epidemic. Both nations exhibit opioid consumption rates significantly above the norm for developed countries. Analgesic type of opioids present both therapeutic benefits and substantial health risks, necessitating balanced drug regulation, careful prescribing, and dedicated opioid stewardship. The role of the cytochrome P450 2D6 (CYP2D6) system (Enzymatic functions) in metabolizing opioids highlights the potential of genotype-guided analgesia. By integrating Pharmacogenomics (PGx), this approach aims to optimize pain management, enhance safety, and reduce addiction risks. This understanding prompted the utilization of multifactor dimensionality reduction (MDR) to explore a range of phenotypes including PGx and gene–gene interactions (GGI) in a healthy cohort, thereby personalizing pain management strategies. The study sampled 100 unrelated healthy Western Iranians and 100 individuals from the 1000 Genome Project. Pre-testing involved searching for PGx annotations (variants associated with drug-gene-diseases) related to pain sensitivity and inflammation using the PharmGKB database, which identified 128 relevant genes. A questionnaire helped select 100 participants who had never used potent opioids but also other psychoactive agents (e.g., nicotine, amphetamines, etc.) and disease-related drugs. Whole-exome sequencing (WES) was then employed to analyze these genes in an Iranian cohort. Further analyses included MDR for identifying synergistic gene annotations and GGI for exploring complex gene interactions through the Visualization of Statistical Epistasis Networks (ViSEN). The study identified a Pain, Anti-Inflammatory, and Immunomodulating agents (PAIma) panel from the 128 genes, resulting in 55,590 annotations across 21 curated pathways. After filtering, 54 significant structural or regulatory variants were identified. This research also highlighted novel gene relationships involving the CYP3A5 gene, hsa-miR-355-5p, Paliperidone, and CYP2D6, which warrant further investigation. This study offers a novel pharmacogenetic framework that could potentially transform opioid prescribing practices to mitigate misuse and enhance personalized pain management. Further validation of these findings from multi countries and ethnic groups could guide clinicians in implementing DNA-based opioid prescribing, aligning treatment more closely with individual genetic profiles.
Graphical abstract
University autonomy is a predictor of English medium instruction in European higher education
Authors: Wingrove Peter , Zuaro Beatrice , Nao Marion , Yuksel Dogan , Littvay Levente , Hultgren Anna Kristina 
Published: November 2024

AbstractDespite extensive research into English as a Medium of Instruction (EMI) in higher education, few if any studies have explored the role of higher education autonomy in driving EMI. This paper tests the novel hypothesis that university autonomy—spearheaded across European higher education through neoliberally predicated ‘steering at a distance’ reforms—predicts EMI. The data are multilevel with higher education institutions (HEIs) nested inside education systems. The University Autonomy Scorecards (Pruvot & Estermann, 2017) operationalise university autonomy at the education-system level (n = 26) and measure four dimensions of autonomy: academic, financial, staffing, and organisational. We include ‘overall autonomy’ as the average. The European Tertiary Education Register provides HEI-level data (n = 1815), which we combine with a count of English-taught degree programmes (ETPs) to measure EMI, provided by Study Portals, the largest online portal of degree programmes. We conduct multilevel regression to analyse the relationships between autonomy and EMI. The results showed that overall autonomy predicts EMI in public universities (p = 0.002). Increasing overall autonomy by one point above the mean increases the likelihood of offering EMI by 9.5%. Academic, staffing, and organisational autonomy predict EMI in public universities, whereas financial autonomy does not. The first to quantify a relationship between university autonomy and EMI, this study offers new insights into how EMI comes about. By revealing a previously obscured interconnectedness between language shift and higher education governance, the study demonstrates the value added of an interdisciplinary approach and proposes a new line of inquiry for future research.
Flexibility of Gestural Production in Captive Groups of Chimpanzees (Pan troglodytes), Sumatran Orangutans (Pongo abelii), and Siamangs (Symphalangus syndactylus)
Authors: Amici Federica , Liebal Katja 
Published: November 2024

AbstractAcross species, communication systems may differ in their levels of flexibility, but comparisons are challenging, because flexibility is not operationalized in a consistent way. In this study, we investigated different aspects of flexibility in the gestural communication systems of 7 groups of captive apes (N = 53), including 19 chimpanzees (Pan troglodytes), 16 Sumatran orangutans (Pongo abelii), and 18 siamangs (Symphalangus syndactylus). We operationalized flexibility in four different ways: (i) the use of one gesture type across several contexts (i.e., contextual flexibility), (ii) the use of many gesture types in the same context (i.e., pragmatic flexibility), (iii) the production of one gesture type with different limbs and/or toward different target locations (i.e., morphological flexibility), and (iv) the ability to combine different signals into a sequence in different orders (i.e., combinational flexibility). Comparisons across individuals and species revealed variation in contextual and morphological flexibility. In particular, contextual flexibility increased with age and was overall higher in chimpanzees than siamangs. Moreover, morphological flexibility increased with social integration and was highest in siamangs and lowest in orangutans. Overall, variation largely reflected differences in social experience and possibly in the socioecological characteristics of the species. Our findings suggest that contextual and morphological flexibility might be good candidates to study interindividual and interspecific variation in primate gestural production.
Breaking Down Barriers: Understanding Determinants of Exercise in Adults with ADHD Symptoms
Authors: Tucker Rory Luke , Williams Claire , Reed Phil 
Published: November 2024

AbstractAutonomous/intrinsic exercise motivation has been found to be negatively linked with Attention Deficit Hyperactivity Disorder (ADHD) symptomatology, but it is unclear how this might be expressed in terms of different determinants of exercise (barriers/facilitators) to Physical Exercise (PE). Additionally, ADHD symptomatology has been found to be linked with increased Exercise Dependence (ED) risk, meaning the relationship between these determinants of exercise and ED should also be considered. This cross-sectional study investigated the relationship between PE, ADHD symptoms, barriers/determinants of exercise, and ED. 362 participants (77.07% female) completed an online survey measuring: PE level (IPAQ-L); ADHD symptomatology (ADHD-RS-IV); subclinical ADHD diagnosis (ADHD-RS-IV); ED (EDS-R) and determinants of exercise (DPAQ). Significant differences were found in the levels of barriers to PE (Coping Planning; Emotion; Beliefs about Capabilities; and Motivation) between subclinical and Non-ADHD participants, with subclinical ADHD participants experiencing more. Additionally, significant positive correlations were observed between determinants of exercise and ED (Motivation; Beliefs about Capabilities; Skills; Emotion; Action Planning; Coping Planning; Goal Conflict; Social). Subclinical ADHD diagnosis did not significantly moderate the relationship between any of the determinants of exercise and PE level. These findings suggest that individuals with subclinical ADHD experience greater levels of certain barriers to exercise, which may need to be overcome or targeted in any potential PE based intervention. However, since some of these barriers were linked with ED risk, caution should be exercised to avoid increasing ED rates further.
Correction to: Trajectories of Affine Control Systems and Geodesics of a Spacetime with a Causal Killing Vector Field
Authors: Bartolo Rossella , Caponio Erasmo 
Published: November 2024

AbstractWe correct a mistake in Bartolo, R., Caponio, E. “Trajectories of Affine Control Systems and Geodesics of a Spacetime with a Causal Killing Vector Field”. J Dyn Control Syst 29, 1409-1424
(2023)
Is it possible to generate accurate 3D point clouds with UAS-LIDAR and UAS-RGB photogrammetry without GCPs? A case study on a beach and rocky cliff
Authors: Gómez-Gutiérrez Álvaro , Sánchez-Fernández Manuel , de Sanjosé-Blasco José Juan , Gudino-Elizondo Napoleón , Lavado-Contador Francisco 
Published: November 2024

Abstract
Context
Recently, Unoccupied Aerial Systems (UAS) with photographic or Light Detection and Ranging (LIDAR) sensors have incorporated on-board survey-grade Global Navigation Satellite Systems that allow the direct georeferencing of the resulting datasets without Ground Control Points either in Real-Time (RTK) or Post-Processing Kinematic (PPK) modes. These approaches can be useful in hard-to-reach or hazardous areas. However, the resulting 3D models have not been widely tested, as previous studies tend to evaluate only a few points and conclude that systematic errors can be found.

Objectives
We test the absolute positional accuracy of point clouds produced using UAS with direct-georeferencing systems.

Methods
We test the accuracy and characteristics of point clouds produced using a UAS-LIDAR (with PPK) and a UAS-RGB (Structure-from-Motion or SfM photogrammetry with RTK and PPK) in a challenging environment: a coastline with a composite beach and cliff. The resulting models of each processing were tested using as a benchmark a point cloud surveyed simultaneously by a Terrestrial Laser Scanner.

Results
The UAS-LIDAR produced the most accurate point cloud, with homogeneous cover and no noise. The systematic bias previously observed in the UAS-RGB RTK approaches are minimized using oblique images. The accuracy observed across the different surveyed landforms varied significantly.

Conclusions
The UAS-LIDAR and UAS-RGB with PPK produced unbiased point clouds, being the latter the most cost-effective method. For the other direct georeferencing systems/approaches, the acquisition of GCP or the co-registration of the resulting point cloud is still necessary.
Identification of meaningful individual-level change thresholds for worsening on the patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE®)
Authors: Lee Minji K. , Mitchell Sandra A. , Basch Ethan , Mazza Gina L. , Langlais Blake T. , Thanarajasingam Gita , Ginos Brenda F. , Rogak Lauren , Meek Eric A. , Jansen Jennifer , Deal Allison M. , Carr Philip , Blinder Victoria S. , Jonsson Mattias , Mody Gita N. , Mendoza Tito R. , Bennett Antonia V. , Schrag Deborah , Dueck Amylou C. 
Published: November 2024

Abstract

Background
We derived meaningful individual-level change thresholds for worsening in selected patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE®) items and their composite scores.

Methods
We used two data sources, the PRO-TECT trial (Alliance AFT-39) that collected PRO-CTCAE data from adults with advanced cancer at 26 United States (U.S.) community oncology practices and the PRO-CTCAE validation study that collected PRO-CTCAE data from adults undergoing chemotherapy or radiation therapy at nine U.S. cancer centers or community oncology practices. Both studies administered selected PRO-CTCAE items and EORTC QLQ-C30 scales. Conceptually, relevant QLQ-C30 domains were used as anchors to estimate meaningful change thresholds for deterioration in corresponding PRO-CTCAE items and their composite scores. Items or composites with ǀρǀ ≥ 0.30 correlation with QLQ-C30 scales were included. Changes in PRO-CTCAE scores and composites were estimated for patients who met or exceeded a 10-point deterioration on the corresponding QLQ-C30 scale. Change scores were computed between baseline and the 3-month timepoint in PRO-TECT, and in the PRO-CTCAE validation study between baseline and a single follow-up visit that occurred between 1 and 7 weeks later. For each PRO-CTCAE item, change scores could range from − 4 to 4; for a composite, change scores could range from − 3 to 3.

Results
Change scores in QLQ-C30 and PRO-CTCAE were available in 406 and 792 patients in PRO-TECT and the validation study, respectively. Across QLQ-C30 scales, the proportion of patients with a 10-point or greater worsening on QLQ-C30 ranged from 15 to 30% in the PRO-TECT data and 13% to 34% in the validation data. Across PRO-CTCAE items, anchor-based meaningful change estimates for deterioration ranged from 0.05 to 0.30 (mean 0.19) in the PRO-TECT data and from 0.19 to 0.53 (mean 0.36) in the validation data. For composites, they ranged from 0.06 to 0.27 (mean 0.17) in the PRO-TECT data and 0.22 to 0.51 (mean 0.37) in the validation data.

Conclusion
In both datasets, the minimal meaningful individual-level change threshold for worsening was one point for all items and composite scores.

ClinicalTrials.gov: NCT03249090 (AFT-39), NCT02158637 (MC1091)
Evaluation of Cadmium, Lead, Chromium, and Nickel Content in Various Types of Nuts: Almonds, Cashews, Hazelnuts, Peanuts, and Walnuts – Health Risk of Polish Consumers
Authors: Ćwieląg-Drabek Małgorzata , Nieć-Leśniak Joanna , Białek-Dratwa Agnieszka , Piekut Agata , Kiciak Agata , Dziubanek Grzegorz , Szczepańska Elżbieta 
Published: November 2024

AbstractWorld production and consumption of nuts continue to rise year on year. Nuts, due to their high nutrient content, are becoming increasingly popular among consumers. A potential health risk may result from the consumption of nuts contaminated with metallic trace elements like cadmium or lead. In this research, we measured the content of Cd, Pb, Cr, and Ni in various edible nuts. All elements were detected using the electrothermal atomic absorption spectrometry analytical technique (ETAAS). The study material comprised 69 nut samples including almonds, cashews, hazelnuts, peanuts, and walnuts available on the Polish market. Indicators such as the hazard quotient (HQ) and hazard index (HI) were used to assess the health risk of consumers. The concentrations of elements in all analyzed samples of nuts were as follows: Cd: peanuts > almonds > hazelnuts > walnuts > cashews, Pb: peanuts > almonds > hazelnuts > walnuts > cashews, Ni: cashews > peanuts > walnuts > hazelnuts > almonds, Cr: almonds > cashews & hazelnuts > peanuts > walnuts. Health risk indicators estimated for consumers whose diet is rich in nuts, in which metallic trace elements were recorded, indicate that an unacceptable impact may occur, and the risk of negative health effects (non-cancer) will be moderate to high.
A Narrative Review of the Digital Equity Gap of Apps for Cigarette Smoking Cessation for Persons Living in the Hispanosphere
Authors: Vilardaga Roger , Stoute Charlotte , Rubenstein Dana , Akingbule Oluwatosin , Gray Madeline 
Published: November 2024

Abstract
Purpose of Review
The Hispanosphere is a vast region of the world that has received little attention in the digital health literature. No study to date has examined the availability and quality of publicly available mobile applications (apps) for cigarette smoking cessation in this region. Three coders utilized the American Psychiatry Association (APA)’s Brief App Evaluation Model Screener (Brief-AEM Screener) to evaluate the quality of the label and public-facing screens of smoking cessation apps in Spanish. Availability of apps in the Hispanosphere was compared to availability of apps in the Anglosphere.

Recent Findings
We identified and reviewed 19 apps in Spanish in Google Play. The median score using the Brief-AEM Screener was 63 out of 100 suggesting generally acceptable app quality and features according to the quality standards for digital health tools proposed by the APA. However, we found (1) notable inaccurate and misleading labelling claims, (2) poor grammar or incomplete translations, and (3) a lack of cultural and linguistic adaptation to countries in the Hispanosphere. Our comparison of smoking cessation apps between the Hispanosphere and the Anglosphere suggested that there is a large digital equity gap between these two regions, with a four to sevenfold gap in app availability.

Summary
There is a relative shortage of quality and quantity of digital health apps for smoking cessation in the Hispanosphere. To ensure the cultural appropriateness of those digital interventions, it is essential that developers of digital health tools establish community partners in the region prior to developing apps for smoking cessation.
Digital artifacts in mathematics education: how can we study the learning processes they promote?
Authors: Baccaglini-Frank Anna , Carotenuto Gemma , Funghi Silvia , Lisarelli Giulia , Miragliotta Elisa 
Published: November 2024

AbstractThis contribution is an elaboration of what was presented by the first author at her invited conference "Digital Artifacts in Mathematics Education" held in September 2023 at the XXII Congress of the Italian Mathematical Union. The aim of the paper is to present to those who are less familiar with qualitative research in Mathematics Education fundamental aspects to consider when studying mathematics learning mediated by digital artifacts. Three examples are presented that show glimpses of mathematical learning mediated by digital artifacts; we discuss how such student learning processes can be captured through adaptations of the Theory of Semiotic Mediation. In the discussion of the three examples, we also highlight the fundamental role played by task design and by the educator in promoting the students’ mathematics learning.
Advancing Our Understanding of Eddy-driven Jet Stream Responses to Climate Change – A Roadmap
Authors: Ossó Albert , Bladé Ileana , Karpechko Alexey , Li Camille , Maraun Douglas , Romppainen-Martius Olivia , Shaffrey Len , Voigt Aiko , Woollings Tim , Zappa Giuseppe 
Published: November 2024

Abstract
Purpose of Review
Extratropical jets and associated storm tracks significantly influence weather and regional climate across various timescales. Understanding jet responses to climate change is essential for reliable regional climate projections. This review serves two main purposes: (1) to provide an accessible overview of extratropical jet dynamics and a comprehensive examination of current challenges and uncertainties in predicting jet responses to greenhouse gas increases and (2) to suggest innovative experiments to advance our understanding of these responses.

Recent Findings
While successive generations of climate model ensembles consistently project a mean poleward shift of the midlatitude zonal-mean maximum winds, there remains considerable intermodel spread and large uncertainty across seasonal and regional jet responses. Of particular note is our limited understanding of how these jets respond to the intricate interplay of multiple concurrent drivers, such as the strong warming in polar and tropical regions, and the relative importance of each factor. Furthermore, the difficulty of simulating processes requiring high resolution, such as those linked to sharp sea surface temperature gradients or diabatic effects related to tropical convection and extratropical cyclones, has historically hindered progress.

Summary
We advocate for a collaborative effort to enhance our understanding of the jet stream response to climate change. We propose a series of new experiments that take advantage of recent advances in computing power and modelling capabilities to better resolve small-scale processes such as convective circulations, which we consider essential for a good representation of jet dynamics.