bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Evaluation of Sex Differences in Patients With Chronic Pain Undergoing an Interdisciplinary Pain Treatment Program
Authors: Racine Mélanie , Solé Ester , Sánchez‐Rodríguez Elisabet , Tomé‐Pires Catarina , Roy Rubén , Jensen Mark P. , Miró Jordi , Moulin Dwight E. , Cane Douglas 
Published: August 2019

AbstractObjectivesTo determine if there are sex differences in a sample of patients participating in a 4‐week interdisciplinary pain treatment program in (1) pretreatment pain intensity, physical function, psychological function, pain beliefs, kinesiophobia, pain catastrophizing, and activity management patterns; and (2) treatment response.MethodsSeventy‐two men and 130 women with chronic pain completed study measures. Analyses of covariance (ANCOVAs) were performed to compare men and women on pretreatment measures. Repeated‐measures ANCOVAs were used to compare both sexes on 3 treatment outcomes (pain intensity, physical function, and depressive symptoms).ResultsBefore treatment, compared to women, men reported higher levels of kinesiophobia, were more likely to view their pain as being harmful, and used more activity pacing when doing daily activities. Women were more likely to use an overdoing activity pattern than men. No sex differences emerged for pretreatment pain intensity, physical function, psychological function, catastrophizing, activity avoidance, or measures of other pain‐related beliefs. At posttreatment, women reported more improvements in pain intensity and physical function compared to men, while both sexes reported similar reductions in depressive symptoms. All effect sizes for statistically significant findings were of small to moderate magnitude.DiscussionThe results of this study suggest that men and women have a comparable profile with respect to the overall burden of chronic pain. Nevertheless, sex differences were found for certain pain beliefs and coping styles. Women appear to reap more benefits from the interdisciplinary pain management program than men. These findings indicate that further research to develop sex‐specific assessment procedures and tailored pain treatments may be warranted.
Acoustic communication of the red‐haired bark beetleHylurgus ligniperda
Authors: Bedoya Carol L. , Brockerhoff Eckehard G. , Hayes Michael , Pawson Stephen M. , Najar‐Rodriguez Adriana , Nelson Ximena J. 
Published: August 2019

AbstractBark beetles (Coleoptera: Curculionidae: Scolytinae) are a speciose subfamily of weevils that primarily live in bark and consequently largely communicate using sound. Having colonized multiple countries outside its native range,Hylurgus ligniperda(Fabricius) is considered to be a successful invader, yet little is known about its acoustic communication. In the present study, we investigate individual sound production and dyadic interactions among males and females ofH. ligniperda. Two temporal parameters (duration and inter‐note interval) and three spectral parameters (minimum, maximum and centroid frequencies) are used as descriptors to quantify call variations depending on behavioural context. We also present a method for automatically extracting and analyzing these calls, which allows acoustic discrimination amongst individuals.Hylurgus ligniperdaexhibits sexual dimorphism in its stridulatory organ. Females do not produce stridulatory sounds, whereas males produce single‐noted calls and modify their spectro‐temporal parameters in accordance with context. Acoustic stimulation from nearby males does not appear to be a causative factor in such modification. Instead, hierarchical clustering analysis shows that physical interactions play a more important role in affecting call parameters than acoustic signals. Centroid and maximum frequencies are the largest contributors to the variability of the data, suggesting that call variations inH. ligniperdamainly occur in the spectral domain.
Interleukin‐1 alpha derived from ultraviolet B‐exposed keratinocytes is associated with a decrease of endocytic collagen receptor Endo180
Authors: Iwahashi Hiroyasu , Kawashima Yoshihito , Masaki Hitoshi 
Published: August 2019

AbstractBackgroundEndo180 contributes to the remodeling of the collagen fibers that comprise the dermal matrix due to the internalization of extracellular collagen fragments. In the sun‐exposed elder skin, an accumulation of collagen fragments was observed in the dermal matrix which was associated with a reduction in Endo180 in the dermal fibroblasts. This suggests that the loss of Endo180 results in the accumulation of collagen fragments in the surrounding fibroblasts and causes interference with dermal matrix remodeling via collagen fibers. The purpose of the study was to identify a mechanism by which ultraviolet B (UVB) exposure induces a loss of Endo 180 with a specific focus on the crosstalk between keratinocytes and fibroblasts.MethodsEndo180 from normal human dermal fibroblasts, which were cultured with a conditioned medium (CM) of UVB‐exposed keratinocytes, was examined using mRNA expression, protein levels and collagen internalization by quantitative RT‐PCR, ELISA, and flow cytometry, respectively.ResultsAlthough UVB irradiation to fibroblasts failed to reduce Endo180, the CM of UVB‐exposed keratinocytes reduced Endo180 in the fibroblasts. Collagen internalization into the fibroblasts was decreased and was associated with a loss of Endo180. Among cytokines secreted from UVB‐exposed keratinocytes, IL‐1α solely reduced Endo180, and the reduction induced by the CM of UVB‐exposed keratinocytes was abolished by the presence of IL‐1RA.ConclusionsThese results indicate that a substance secreted from UVB‐exposed keratinocytes regulates Endo180 expression and that IL‐1α may play an important role in the maintenance of Endo180.
Suboptimal UVA attenuation by broad spectrum sunscreens under outdoor solar conditions contributes to lifetime UVA burden
Authors: Coelho Sergio G. , Rua Diego , Miller Sharon A. , Agrawal Anant 
Published: August 2019

AbstractBackgroundBroad spectrum sunscreens with a sun protection factor (SPF) of 15 or greater are indicated to decrease the risk of skin cancer and early skin aging caused by the sun if used as directed with other sun protection measures. To determine whether sunscreen product performance is compromised under solar exposure and to test spectral uniformity of protection across the UVA spectrum, we tested broad spectrum sunscreens with a variety of active pharmaceutical ingredients (APIs) and in a variety of dosage forms.MethodsA cross‐sectional market survey of 32 sunscreen drug products containing either organic or inorganic APIs with SPFs of 15, 30, 50, and 70 was tested. UV doses were delivered via natural sun in Silver Spring, Maryland between June and September of 2017.ResultsOf the 32 sunscreen drug products, 6 products failed to meet their broad spectrum claim under solar exposure. Using FDA's new proposal to strengthen sunscreen broad spectrum requirements, spectral uniformity based on the mean sunscreen absorbance of UVA1(340‐400 nm)/UV (290‐400 nm) indicated that ~40% of sunscreen drug products tested had suboptimal UVA protection.ConclusionUS consumers may unknowingly be receiving up to 36% more transmitted UVA when selecting between similarly labeled broad spectrum sunscreen drug products with equivalent SPF values. FDA's new proposal may help decrease consumers' overall lifetime UVA burden. Spectral absorbance data on sunscreen performance can be used to further improve the coupling of broad spectrum protection to a product's SPF value so that consumers have improved proportional increases in UV protection.
Stability and change in emotional processing across development: A 6‐year longitudinal investigation using event‐related potentials
Authors: Pegg Samantha , Dickey Lindsay , Mumper Emma , Kessel Ellen , Klein Daniel N. , Kujawa Autumn 
Published: August 2019

AbstractERPs reveal the temporal dynamics of emotional processing and are easily assessed in children. Yet, little longitudinal research has examined ERPs sensitive to emotion across development. We aimed to systematically identify timing and spatial distributions of ERPs sensitive to emotion in a longitudinal sample of youth (N = 62) using principal component analysis (PCA) and evaluate stability and change in emotional responses across development. Participants completed an emotional interrupt paradigm in childhood (Mage = 9.38, SD = 0.42), early adolescence (Mage = 13.03, SD = 0.24), and midadolescence (Mage = 15.16, SD = 0.17). ERPs were recorded to unpleasant, pleasant, and neutral images. Participants were instructed to respond to a target while viewing images. Two components sensitive to emotion emerged across development: P300/early late positive potential (LPP) and late LPP. The P300/early LPP component was characterized by an enhanced positivity for unpleasant compared to pleasant and neutral images. The late LPP was enhanced for both unpleasant and pleasant compared to neutral images, and more positive for unpleasant compared to pleasant images. The components showed moderate to strong stability. Overall LPP magnitude decreased from childhood into adolescence. There was a developmental shift in distributions from occipital sites in childhood to centroparietal sites in midadolescence. Results support use of PCA to inform scoring windows and electrode selection. The shift in distribution may reflect developmental focalization in underlying neural circuitry. Future work is needed using multimodal approaches to further understand the relationship between ERPs and changes in neural circuitry across development.
Interpersonal physiological regulation during couple support interactions: Examining the role of respiratory sinus arrhythmia and emotional support
Authors: Borelli Jessica L. , Shai Dana , Fogel Yaakobi Shlomit , Levit‐Binnun Nava , Golland Yulia 
Published: August 2019

AbstractIn times of need, people seek comfort and support from close others. Support provision is an integral component of attachment relationships, one that is linked with physical and psychological well‐being. Successful support provision is believed to be grounded in transactions of sensitive, caring behavior between caregivers and support seekers and to serve a profound regulatory function. However, physiological processes underlying support transactions have not been previously studied. We assessed autonomic vagal regulation and coded spontaneous emotional support behaviors in N = 100 heterosexual couples involved in a support interaction. We focused on cardiac vagal activation, operationalized as the increase in respiratory sinus arrhythmia (RSA) from baseline to interaction, as an indicator of regulatory efforts. Analyses revealed a negative association between caregivers' and support seekers' regulatory efforts, which was mediated by emotional support behaviors. We found that caregivers with greater increases in RSA from baseline to interaction provided more emotional support to their partners. Such emotional support was associated with smaller increases in support seekers' RSA and with support seekers' perceptions of their partners as being more sensitive to their needs. Finally, these links were only significant among dyads in which caregivers reported lower levels of attachment anxiety. We interpret these results in the framework of interpersonal regulatory processes, suggesting that provision of support may impose regulatory demands on the side of the caregivers, which in turn could result in attenuated regulatory efforts and positive partner perceptions for the support seekers.
Ventromedial prefrontal cortex connectivity during and after psychological stress in women
Authors: Ginty Annie T. , Kraynak Thomas E. , Kuan Dora C. , Gianaros Peter J. 
Published: August 2019

AbstractThe ventromedial prefrontal cortex (vmPFC) integrates sensory, affective, memory‐related, and social information from diverse brain systems to coordinate behavioral and peripheral physiological responses according to contextual demands that are appraised as stressful. However, the functionality of the vmPFC during stressful experiences is not fully understood. Among 40 female participants, the present study evaluated (a) functional connectivity of the vmPFC during exposure to and recovery following an acute psychological stressor, (b) associations among vmPFC functional connectivity, heart rate, and subjective reports of stress across individuals, and (c) whether patterns of vmPFC functional connectivity were associated with distributed brain networks. Results showed that psychological stress increased vmPFC functional connectivity with individual brain areas implicated in stressor processing (e.g., insula, amygdala, anterior cingulate cortex) and decreased connectivity with the posterior cingulate cortex and thalamus. There were no statistical differences in vmPFC connectivity to individual brain areas during recovery, as compared with baseline. Spatial similarity analyses revealed stressor‐evoked increased connectivity of the vmPFC with the so‐called dorsal attention, ventral attention, and frontoparietal networks, as well as decreased connectivity with the default mode network. During recovery, vmPFC connectivity increased with the frontoparietal network. Finally, individual differences in heart rate and perceived stress were associated with vmPFC connectivity to the ventral attention, frontoparietal, and default mode networks. Psychological stress appears to alter network‐level functional connectivity of the vmPFC in a manner that further relates to individual differences in stressor‐evoked cardiovascular and affective reactivity.
Exports of primary goods and human capital accumulation
Authors: Hou Yulin , Karayalcin Cem 
Published: August 2019

AbstractMany developing countries have experienced export‐led growth in the last half century. This paper asks whether the content of what economies export matters for human capital accumulation. We construct a small open economy model and find that expansion of primary exports can harm human capital accumulation if the economy is initially allocating significant resources to the production of primary goods. We then test this prediction empirically using Latin American data over the period 1965 to 2010 and find robust evidence in support of the hypothesis that a shift towards primary exports reduces human capital accumulation. Given the importance of the latter for long‐run growth, our results suggest a potential role for policy intervention.
Suicidal Ideation in Elite Schools: A Test of the Interpersonal Theory and the Escape Theory of Suicide
Authors: Landrault Hélène , Jaafari Nemat , Amine Mohamed , Malka Gabriel , Selimbegović Leila , Chatard Armand 
Published: August 2019

ObjectiveThe present study compared the ability of two contemporary theories of suicidal behavior—the interpersonal and escape theories of suicide—to predict suicidal ideation. The interpersonal theory proposes that the interaction of perceived burdensomeness and thwarted belongingness predicts suicidal ideation. The escape theory proposes that feelings of failure predict suicidal ideation and that escape motivation mediates this relationship. The present study intended to determine which of the two theories more successfully explains suicidal ideation.MethodA sample of 306 students from elite schools in Morocco (193 women, Mage = 21.21 years, predominantly Muslims) completed a questionnaire assessing feelings of failure and escape motivation, perceived burdensomeness and thwarted belongingness, suicide ideation, and control variables.ResultsIn line with previous research, separate tests revealed support for the two theories. Interestingly, when entered simultaneously in a multiple regression analysis, the two frameworks explained a unique and cumulative part of the variance in suicidal ideation. Moreover, the effects remained significant after controlling for past suicide attempts, depression, hopelessness, and stress.ConclusionsThe findings suggest that combining the interpersonal and escape theories of suicide could help better explain the emergence of suicidal ideation among college students.
Rescheduling Part 2 of the 11+ reduces injury burden and increases compliance in semi‐professional football
Authors: Whalan Matthew , Lovell Ric , Steele Julie R. , Sampson John A. 
Published: August 2019

Although the 11+ program has been shown to reduce injuries in sub‐elite football, program compliance is typically poor, suggesting that strategies to optimize delivery are necessary. This study investigated the effect of rescheduling Part 2 of the three‐part 11+ program on program effectiveness. Twenty‐five semi‐professional football clubs were randomly allocated to either a Standard‐11+ (n = 398 players) or P2post group (n = 408 players). Both groups performed the 11+ program at least twice a week throughout the 2017 football season. The Standard‐11+ group performed the entire 11+ program before training activities commenced, whereas the P2post group performed Parts 1 and 3 of the 11+ program before and Part 2 after training. Injuries, exposure, and individual player 11+ dose were monitored throughout the season. No significant between group difference in injury incidence rate (P2post vs Standard‐11+ = 11.8 vs 12.3 injuries/1000 h) was observed. Severe time loss injuries > 28 days (33 vs 58 injuries; P < .002) and total days lost to injury (4303 vs 5815 days; P < .001) were lower in the P2post group. A higher 11+ program dose was observed in the P2post (29.1 doses; 95% CI 27.9‐30.1) versus Standard‐11+ group (18.9 doses; 95% CI 17.6−20.2; P < .001). In semi‐professional football, rescheduling Part 2 of the 11+ program to the end of training maintained the effectiveness of the original 11+ program to reduce injury incidence. Importantly, rescheduling Part 2 improved player compliance and reduced the number of severe injuries and total injury burden, thereby enhancing effectiveness of the 11+ program.
An open‐label trial of cryopreserved human umbilical cord in the treatment of complex diabetic foot ulcers complicated by osteomyelitis
Authors: Marston William A. , Lantis John C. , Wu Stephanie C. , Nouvong Aksone , Lee Tommy D. , McCoy Nicholas D. , Slade Herbert B. , Tseng Scheffer C. 
Published: August 2019

AbstractClinical trials of potential new therapies for diabetic foot ulcers rarely enroll patients whose wounds extend to muscle, fascia, or bone with clinical and radiographic evidence of underlying osteomyelitis. An open‐label, multicenter trial of cryopreserved human umbilical cord (TTAX01) was undertaken in 32 subjects presenting with such complex wounds with a mean duration of 6.1 ± 9.0 (range: 0.2–47.1) months and wound area at screening of 3.8 ± 2.9 (range: 1.0–9.6) cm2. Aggressive surgical debridement at baseline resulted in 17 minor amputations and an increase in mean wound area to 7.4 ± 5.8 (range: 1.1–28.6) cm2. All subjects were placed on systemic antibiotics for at least 6 weeks in conjunction with baseline application of TTAX01. Repeat applications were made at no less than 4‐week intervals over the 16‐week trial. Initial closure occurred in 18 of 32 (56%) wounds, with 16 (50%) of these having confirmed closure in 16 weeks with a median of one‐product application. Cases with biopsy confirmed osteomyelitis (n = 20) showed initial closure in 12 (60%) wounds and confirmed closure in 10 (50%) wounds. Four of the five ulcers presenting as recurrences experienced confirmed closure. Mean overall time to healing was 12.8 ± 4.3 weeks. Mean wound area reduction from baseline was 91% for all wounds. Of the 16 wounds without confirmed closure during the 16‐week treatment period, five (31.3%) achieved 99–100% wound area reduction by their final visit. The product was well tolerated. Two minor amputations occurred during the study period due to recurrent or persistent osteomyelitis; however, there were no major amputations.
Time trends and sociodemographic determinants of preterm births in pregnancy cohorts in Matlab, Bangladesh, 1990–2014
Authors: Rahman Anisur , Rahman Monjur , Pervin Jesmin , Razzaque Abdur , Aktar Shaki , Ahmed Jamal Uddin , Selling Katarina Ekholm , Svefors Pernilla , El Arifeen Shams , Persson Lars Åke 
Published: August 2019

IntroductionPreterm birth is the major cause of under-five mortality. Population-based data on determinants and proportions of children born preterm are limited, especially from low-income countries. This study aimed at assessing time trends and social, reproductive and environmental determinants of preterm births based on a population-based pregnancy cohort over 25 years in rural Bangladesh.MethodsIn this cohort study in Matlab, a rural area in Bangladesh, we used data from the Health and Demographic Surveillance System from 1990 to 2014. Gestational age at birth was based on the reported last menstrual period and verified by ultrasound assessments. Preterm birth proportions were assessed within strata of social and reproductive characteristics, and time series analysis was performed with decomposition for trend and seasonality. We also determined the prevented fractions of preterm birth reduction associated with social and demographic changes during the follow-up period.ResultsAnalyses were based on 63 063 live births. Preterm birth decreased from 29% (95% CI 28.6 to 30.1) in 1990–1994 to 11% (95% CI 10.5 to 11.6) in 2010–2014. Low education, older age and multi-parity were associated with higher proportions of preterm births across the study period. Preterm births had a marked seasonal variation. A rapid increase in women’s educational level and decrease in parity were associated with the decline in preterm births, and 27% of the reduction observed from 1990 to 2014 could be attributed to these educational and reproductive changes.ConclusionThe reduction in preterm birth was to a large extent associated with the sociodemographic transition, especially changes in maternal education and parity. The persistent seasonal variation in the proportion of preterm birth may reflect the environmental stressors for pregnant women across the study period. Continued investments in girls’ education and family planning programmes may contribute to further reduction of preterm births in Bangladesh.