bluuebunny/crossref_metadata_2025_split huggingface dataset:
Normative Values of The Retinal Macular Thickness in a Middle Eastern Population.
Authors: Saad Mouna Al , Shatarat Amjad T. , AlRyalat Saif Aldeen 
Published: December 2018

Abstract
Background: Since the normative value of the retinal macular thickness is undocumented in the Middle East, the aim of this work is to assess the normative values of the macular thickness in healthy eyes in a Middle Eastern population and its relationship with age, sex, and laterality.
Methods: 98 individuals were randomly selected from volunteers visiting the Jordan University Hospital in Amman, Jordan. Measurements were obtained using the Fourier domain optical coherence tomography (OCT). Multivariable regression models were developed to obtain predicted normative values with adjustment to candidate variables. In addition, the effect of age, sex and laterality were evaluated.
Results: The average central fovea macular thickness was 232.1 (±30.85) um. The quadratic value of the retinal macular thickness decreased from the superior value of 299.71 (±23.67) um to the inferior value of 296.46 (±28.85) um and a nasal figure of 93.63 (±26.86) um. The temporal area has the thinnest value of 293.43 (±30.78) um. Central thickness was higher in males with a mean variation of 11.67 um (95% CI: 2.41 to 20.93) (p= 0.003). The thickness was highest within 3mm diameter from the center and decreased towards the periphery Eye sidedness didn’t contribute to variability of the macular thickness.
Conclusion: Our set of predicted normative data may be used to interrupt measurement of the macular thickness in Middle Eastern population. The average fovea macular thickness among Jordanians is consistent with previously reported values. Normative values from additional Middle Eastern populations are required to appraise our module.
The results of two-stage optico-functional rehabilitation of patients with refractive disorders and the risk of postoperative asthenopic syndrome after FemtoLASIK
Authors: Mushkova I. A. , Mitronina M. L. , Kornyushina T. A. , Maychuk N. V. , Shamsetdinova L. T. 
Published: December 2018

Purpose. A comparative analysis of the results of two-stage optico-functional rehabilitation of patients with a high risk of postoperative asthenopic syndrome (AS).Materials and methods. 36 patients (72 eyes) who had no binocular vision at a distance of 5 m and had a symmetrical position of the eyes, or a position close to symmetry, were randomly divided into 2 equal groups of comparison. Patients in both groups underwent functional treatment followed by the correction of refractive errors with FemtoLASIK technology. To eliminate accommodation dysfunctions, a medical device OXYS was used. Diploptic treatment was carried out using a Speckle-M laser apparatus and Bagolini raster glasses. To expand fusional reserves, a prism compensator (OKP-20, Russia) and a Speckle-M laser apparatus were used. The patients of the first group underwent a fast course of medical and functional rehabilitation for 5 working days (2 times a day with a break of 2–3 hours). As an additional pharmacological support, daily instillations of phenylephrine hydrochloride 2.5 % without preservatives were prescribed. The other group received the same functional treatment for 10 working days.Results. After the fast and the standard rehabilitation courses, the patients revealed an increase in absolute accommodation and a decrease in the coefficient of micro fluctuations, an expansion of fusional reserves, an increase in stereovision acuity, and an increased number of cases of binocular vision. No statistically significant difference of clinical and functional parameters obtained as a result of the fast and the standard rehabilitation courses was revealed.Conclusions. Functional and medicament treatment of patients with refractive disorders and the absence of binocular vision prior to FemtoLASIK is shown to be effective. This treatment reduces the risk of postoperative AS and increases the patient’s satisfaction with the results of the surgery.
An algorithm for managing surgical patients with acute retinal necrosis
Authors: Neroev V. V. , Ilyukhin P. A. , Tankovsky V. E. , Fedotov R. A. 
Published: December 2018

Purpose. To increase the efficiency of surgical treatment and develop an algorithm for managing patients with the consequences of acute retinal necrosis (ARN).Material and methods. The study included 35 patients (42 eyes) aged 18 to 74 with acute retinal necrosis. All patients underwent a microinvasive (23 Ga) vitrectomy with membrane peel, endolaser coagulation of the retina and endotamponade of the vitreal cavity with silicone oil. The operated eyes were divided into 2 groups. The main group consisted of 17 eyes with a clinical picture of fibrosis of the vitreous without retinal detachment (10 eyes) and retinal detachment without pronounced fibrosis of the vitreous (7 eyes). The comparison group included 25 eyes which had retinal detachment and fibrosis of the vitreous at the time of surgery. The visual acuity varied between incorrect light projection and 0.15 with correction.Results. A stable anatomical and optical result was achieved in all cases. Complete adhesion of the detached retina was achieved in 94.1 %, which is explained by the fact that surgical treatment was in most cases performed in the absence of pronounced stages of proliferative vitreoretinopaty. In all cases of the main group, an increase in visual acuity was noted. In 53 % of cases, visual acuity achieved 0.1 to 0.3 and in the remaining 47 % it was 0.3 % or above. This can be accounted for by the prevalence of peripheral necrotic lesions, as well as a lower incidence of macular edema and optic neuropathy. However, in the comparison group, an increase in visual acuity was only observed in 56 % cases, with visual acuity reaching 0.1 or higher only in 24 % of the eyes. A high frequency (72 %) of necrosis expansion to the posterior eye pole with an irreversible damage to the optic nerve and the macular region was revealed.Conclusion. Active dynamic observation of patients with ARN helps detect changes requiring surgical treatment, which leads to higher functional and anatomical outcomes, as well helps avoid the disability of the patients. Surgical treatment prior to the formation of retinal detachment in severe traction syndrome with or without retinal tears is advisable. An algorithm was proposed for managing surgical patients, depending on the clinical manifestations of ARN effects.
Angiogenic properties of catecholamines from the viewpoint of the pathogenesis of retinopathy of prematurity
Authors: Katargina L. A. , Khoroshilova-Maslova I. P. , Bondarenko N. S. , Nikishina J. O. , Murtazina A. R. , Maybogin A. M. , Osipova N. A. , Panova A. Yu. , Sudovskaya T. V. , Ugryumov M. V. 
Published: December 2018

Purpose: to assess the level of catecholamines norepinephrine and dopamine in rat retina with experimental retinopathy of prematurity (EROP) at a time corresponding to the peak of neovascularization.Material and methods. The study was performed on 41 infant Wistar rats (82 eyes). The rats were divided into 2 groups: the experimental group (with EROP, n = 21) and the control group (n = 20). In order to reproduce the EROP, the newborn rats were placed for 14 days in the incubator together with their mother. Every 12 hours, the oxygen concentration in the incubator ranged from 60 to 15 %. The control group consisted of pups who were held in conditions with a normal oxygen content (21 %) from the moment of birth. The pups were withdrawn from the experiment on the 10th, 14th, 23rd and 28th day, whereupon they were subjected to binocular enucleation followed by histological examination, in addition, the content of noradrenaline and one of the metabolites of dopamine (L-DOPA) was determined in retinal samples of the eyeballs obtained on the 23rd day by highly effective liquid chromatography technique with electrochemical detection.Results. Histological examination showed that in our EROP model the neovascularization peak occurs on the 23rd day of the experiment. At this time rat pups with EROP showed a significantly lower retinal L-DOPA level as compared to the control values (13.99 ng/g and 30.5 ng/g, respectively), and the norepinephrine level significantly exceeded such values (63.7 ng/g and 7.69 ng/g, respectively).Conclusion. A relative deficiency of dopamine and a relative excess of norepinephrine of the rat pups with EROP is noted at the time of the highest vascular activity of the retina. The obtained data confirm anti-angiogenic properties of dopamine and pro-angiogenic properties of noradrenaline in the second phase of EROP development.
An experimental study of drainage properties of fibrillar-structured materials for glaucoma surgery
Authors: Khodzhaev N. S. , Kolomeytsev M. N. 
Published: December 2018

Purpose: to study the drainage properties of fibrillar-structured materials under conditions of hydrodynamics which are maximally close to physiological conditions, using the results of a bench experiment.Material and methods. Drainage properties of fibrillary-structured materials have been studied in several bench experiments using an original device that creates conditions of eye hydrodynamics maximally close to physiological conditions. The studied materials were produced by the method of electrospinning, vacuumized and sterilized. The effect of drainage structure density and drainage type (polylactide, copolymer of polylactide and caprolactone, polycaprolactone) on the drainage capacity were evaluated, as well as the stability of their drainage properties.Results. The research revealed considerable drainage properties of all investigated objects. The study of various drainages showed a statistically significant effect of the density of the internal structure and type on the drainage capacity. Also, a nonlinear increase in the filtering capacity with a regular increase in perfusion pressure was revealed. This phenomenon, regarded as adaptive hydrodynamic properties, in addition to reducing the level of the intraocular pressure (IOP), can contribute to smoothing of diurnal fluctuations, thereby enabling the stabilization of visual functions. In the experiment, the optimal structure was determined, which corresponds to the conditions of physiological hydrodynamics of the eye and ensuring the maintenance of intraocular pressure in the low-norm region. Fibrillar structured drains made of polylactide and its copolymer with polycaprolactone with a porosity of 78–84 %, an average fiber diameter of 5–5.7 μm and a pore size of 25.8–29 μm optimally correspond to hydrodynamic conditions maximally close to physiological conditions.Conclusion. Fibrillar-structured materials have significant drainage properties depending on the density of the internal structure and the type of drainage due to threshold activation of additional pores create the conditions, close to the physiological ones, for the regulation of the IOP, and ensure the persistence of visual functions after operations.
The efficiency of monotherapy of patients with primary open-angle glaucoma with Bimatoprost 0.03 % (Bimoptic)
Authors: Korotkikh S. A. , Zhiborkin G. V. , Knyazeva E. S. , Rusakova L. V. 
Published: December 2018

Purpose: to evaluate the hypotensive effect and adverse reactions occurrence in patients with primary open angle glaucoma (POAG) who received Bimatoprost (Bimoptic Rompharm) monotherapy.Materials and methods. 46 patients (75 eyes) with stage I–III POAG were prescribed bimatoprost therapy. Of these, 16 patients (20 eyes) had newly diagnosed glaucoma, 15 patients (27 eyes) previously received treatment with prostaglandin analogs (APG — Latanoprost), and 15 patients (28 eyes) previously received treatment with a fixed combination (FC) composed of timolol B-blocker and brinzolamide carbonic anhydrase inhibitor. The reason for transferring the patient from therapy with APG and FC to monotherapy with Bimatoprost was insufficient hypotensive effect of APG/FC therapy, and the presence of dry eye syndrome of varying severity in most patients. The results were evaluated after 1, 4 and 12 weeks of Bimatoprost therapy. Results. A hypotensive effect of monotherapy with Bimatoprost was confirmed in patients with newly diagnosed POAG. An additional hypotensive effect was revealed when patients with POAG were transferred from APG and FC therapy to monotherapy with Bimatoprost. Adverse reactions: mild and moderate hyperaemia, periorbital manifestations such as skin pigmentation, deepening of upper eyelid folds, narrowing of the palpebral fissure (ptosis) were noted, respectively, in 8, 6.7, 1.3, 2.7, 2.7 % of cases respectively, but did not require a discontinuation of the therapy in any patient. Eyelash growth was noted by 3 patients (4 %). This effect was not considered to be a side effect, since none of the patients bothered. In 47 % of patients who had previously received APG and FC therapy and had dry eye syndrome of varying severity, objective and subjective positive changes relating to dry eye syndrome was noted. A positive dynamic of morphometric parameters of the optic nerve and cells of the retinal ganglion complex was revealed in patients of all groups of study.Conclusion. Monotherapy with Bimatoprost can be recommended as therapy of choice for patients with newly diagnosed glaucoma, and those previously receiving antihypertensive therapy with PGAs or fixed combinations (-blocker + carbonic anhydrase inhibitor) including those having dry eye syndrome of varying severity.
Experiences of using Aflibercept in diabetic macular edema treatment: data from routine clinical practice
Authors: Santoro E. Yu. 
Published: December 2018

Purpose. To assess the effectiveness and safety of intravitreal aflibercept injections in clinically significant diabetic macular edema (DME) in a routine clinical practice.Material and methods. This was a prospective, observational, single-center study. During the study, anti-VEGF treatment naïve patients with clinically significant DME received five monthly intravitreal injections of aflibercept 2 mg followed by bimonthly injections. The observation period was 1 year.Results. The study included 11 eyes of 10 patients with clinically significant DME. Use of 8 intravitreal aflibercept injections resulted in central retinal thickness (CRT) reduction by 50 % from the baseline within 1 year of therapy. CRT decreased on average from 446.18 ± 106.88 μm to 226.27 ± 44.56 μm by the end of observational period. In addition, an increase in visual acuity was observed from an average from 0.33 ± 0.22 at the start of therapy to 0.62 ± 0.33 at the end of the observation. Serious adverse events over the entire period of treatment were not observed.Conclusion. Aflibercept showed high efficacy and safety in the treatment of clinically significant DME in routine clinical practice. To obtain optimal functional and morphological results in the treatment of patients with DME, it is necessary to start therapy with 5 loading intravitreal aflibercept injections.
Dry eye treatment optimization in patients prior to refractive surgery
Authors: Sakhnov S. N. , Yanchenko S. V. , Malyshev A. V. , Blyagoz Z. M. , Klimenova G. A. 
Published: December 2018

Purpose. To evaluate the effectiveness of dry eye syndrome (DES) treatment in patients with meibomian gland dysfunction (MGD) before refractive surgery.Materials and methods. We examined 48 women (aged 29.6 ± 3.9 years) with myopia, DES, and MGD of noninfectious etiology before performing LASIK. Group 1 of these patients received presurgical correction of DES for 2 months, including instillation of 3 % trehalose as a bioprotector (Thealoz®; 3–4 times a day); application of 5 % dexpanthenol in the conjunctival cavity (before going to bed); eyelid hygiene (2 times per day), which included cleaning (Theagel®), warm compresses on eyelid area, massage of eyelid margin (Blephaclean wipes). Group 2 only received bioprotective and reparative therapy for 2 months. Testing included a standard ophthalmological examination; assessment of DES symptoms (OSDI scale, points); BUT test (sec) and Schirmer-1 test (Sh-1, mm); measuring the height of the lower tear meniscus (optical coherence tomography, μm); lissamine green staining with calculation of xerosis index by Bijsterveld (points); assessment of MGD severity (points). Processing of the results included calculation of M ± s; Wilcoxon t-test, Mann Whitney U-test.Results. A positive change of OSDI (decrease from 31.9 ± 2.9 to 8.71 ± 1.1 points), xerosis index (decrease from 4.71 ± 0.5 to 2.1 ± 0.3 points) and BUT test (increase from 4.14 ± 0.53 to 8.66 ± 0.93 sec) was significantly stronger in patients of group 1 (p < 0.05) in comparison with patients of group 2 (decrease in OSDI from 33.2 ± 3.1 to 15.6 ± 2.4 points; decrease of xerosis index from 4.75 ± 0.50 to 3.7 ± 0.5 points; BUT increase from 4.21 ± 0.47 to 6.05 ± 0.73 sec). Apparently, this was caused by a significant decrease in the severity of MGD (from 2.1 ± 0.3 to 0.9 ± 0.2 points) and a decrease in the severity of lipid deficiency due to eyelid hygiene in patients of group 1. In group 2, MGD severity change proved unreliable. Change of Sh-1 and the height of the lower tear meniscus was unreliable in all cases. Conclusion. The inclusion of eyelid hygiene (Theagel and Blephaclean) in the pre-surgery preparation of patients with DES and MGD leads to a more significant correction of eye surface condition compared to isolated bioprotective and reparative therapy, thus providing an opportunity of more favorable conditions for carrying out surgical correction of ametropia.
Treatment and prevention of intraocular pressure increase after ophthalmic surgeries
Authors: Antonov A. A. , Kozlova I. V. , Kosova D. V. 
Published: December 2018

The literary review is focused on reactive hypertension after eye surgeries. Possible causes of increased intraocular pressure are described. Methods of therapy and prevention of reactive hypertension after cataract phacoemulsification and intravitreal injections are analyzed. Literary data show an emphasis on the efficacy and safety of applying a fixed combination of brimonidine and timolol.
Evaluating the impact of spatial variability of precipitation on streamflow simulation using a SWAT model
Authors: Xue Feng , Shi Peng , Qu Simin , Wang Jianjin , Zhou Yanming 
Published: December 2018

AbstractThe spatial variability of precipitation is often considered to be a major source of uncertainty for hydrological models. The widely used Soil and Water Assessment Tool (SWAT) is insufficient to calculate a sub-basin's mean areal precipitation (MAP) since it only uses data from the rainfall station nearest to the centroid of each sub-basin. Therefore, Inverse Distance Weighting (IDW), Thiessen Polygons (TP) and Ordinary Kriging (OK) were applied as alternative interpolation methods in this study to calculate sub-basin MAP. The MAP results from the four methods used for the Xixian Basin were quite different in terms of amount and spatial distribution. The SWAT model performance was then assessed at monthly and daily timescales, based on Nash–Sutcliffe efficiency (NSE), the Coefficient of Determination (R2) as well as Percentage Bias (PBIAS) at the basin outlet. The results under different network densities and spatial distributions of gauge stations indicated that the modified MAP models did not have an advantage over the default Nearest Neighbour (NN) method in simulating monthly streamflow. However, the modified areal precipitation obtained through IDW and TP showed relatively high accuracy in simulating daily flows as the applied rainfall stations changed. The difference in terms of estimated rainfall and streamflow in this study confirmed that evaluation of interpolation methods is necessary before building a SWAT model.
MIELOMA MÚLTIPLO: UMA NOVA ÓTICA SOB A ABORDAGEM DIAGNÓSTICA- RELATO DE CASO
Authors: De Oliveira Thiago Wesley 
Published: December 2018

O mieloma múltiplo é um tumor maligno caracterizado por proliferação de plasmócitos na medula. O tema atinge maior relevância pelo aumento na expectativa de vida da população, já que acomete mais idosos. Este trabalho objetiva relatar um caso de mieloma e sua abordagem no estágio tardio. Indivíduo do sexo masculino, 85 anos, com queixas de astenia, oligúria e dor lombar há 3 meses, foi admitido no Hospital Universitário de Vassouras (HUV) e chamava a atenção pela intensa palidez cutâneo- mucosa. Ressonância magnética revelou lesões ósseas líticas na região sacral e mielograma exibiu plasmocitose medular compatível com mieloma múltiplo, porém logo após o diagnóstico o paciente evoluiu para óbito por sepse nosocomial. Bibliografia ressalta a importância do reconhecimento precoce para a maior sobrevida a partir do tratamento instituído. Portanto, mesmo sendo uma doença incurável, o diagnóstico antecipado favorece tratamento precoce, melhora da qualidade de vida e maior sobrevida para esses pacientes.
Grandparents - Grandchildren Relationship in Iran, 2017
Authors: Momtaz Yadollah Abolfathi , Vidouje Mahboube Mahdi , Foroughan Mahshid , Sahaf Robab , Laripour Reza 
Published: December 2018

Introduction:With the continuing growth of aged populations, it is imperative to find ways to maintain and improve the quality of life in old age. It has been documented that grandparents-grandchildren relationship is significantly contributed to quality of life of older adults. This study was conducted to identify the status and associated factors of grandparents-grandchildren relationship in a sample of Iran.Methods:This cross-sectional study was conducted on 377 community dwelling older adults 60 years and over living in Kashan, Iran. A multistage proportional random sampling technique was applied to obtain the sample. The grandparent -grandchildren relationship was measured by a researcher-developed 16-item scale. The data were analyzed using SPSS version 23 and AMOS 23.Results:The mean age of the respondents was 70.42(SD = 8.20) years. About 62% of the respondents were female and 60.7% were married. The average score of grandparents-grandchild relationship was 67.60(SD = 12.47). The multiple linear regression analysis revealed a significant model (F(11, 365)= 19.05,P< 0.001), where information communication technology of grandparents, geographical distance between grandparents and grandchildren, and the quality of relationship between grandparents and parents of grandchildren were the most important predictors of the grandparents-grandchildren relationship.Conclusion:The findings from the current study showed that status of grandparents-grandchildren relationship is moderate to high and influenced by some factors. It is, therefore, suggested that policymakers pay more attention to strengthening grandparent-grandchild relationship by providing educational programs for families and encouraging the elderly to learn and use information communication technology.