bluuebunny/crossref_metadata_2025_split huggingface dataset:
Síndrome metabolico y obesidad según criterios IDF/ALAD en adultos de la ciudad de Salta
Authors: Gotthelf Susana Judith , Rivas Patricia C. 
Published: August 2018

Abstract:Objective: To estimate the prevalence of Metabolic Syndrome in adults in Salta according to criteria from International Federation of Diabetes (IFD) and Latin American Association of Diabetes (LAAD). Analyze the relationship between obesity and Metabolic Syndrome. Methodology: cross-sectional study, secondary data base (Nutritional Survey, Salta. 2014) Variables: MS: criteria IFD/LAAD, sex, age, nutritional status. Analysis: frequency distribution, comparison of measures. Logistic regression. EXCEL, SPSS 18. Results: We evaluated 425 adults; 63.5 % women. The prevalence of MS was 20.9% according to LAAS, 30.8% according to IFD, greater in males (34.2 and 41.9%). The prevalence of Overweight/Obesity was 61.8%. The mean values of BMI, triglycerides and blood pressure in males were higher than the critical limits. Regression models (IFD/LAAD) showed that the probability to develop MS was greater in males, increased with age (?65 years) and with overweight/obesity. Conclusions: we observed differences in the prevalence of MS according to the medical diagnosis used, being associated with overweight/obesity.
Monitoreo de Cov´s en el aire de la ciudad de Córdoba, Argentina
Authors: Sbarato R. D. , Rubio M. 
Published: August 2018

On April 22, 1997, the city of Cordoba opens the Municipal Environmental Observatory. Up to the year 2001, the city had an automatic monitoring net of atmospheric pollution generating continuous measurements of contaminants criteria (NO2, SO2, CO, O3 and PM10). Other non conventional atmospheric contaminants such as Volatile Organic Compounds (VOC’s) were also measured but sporadically and without consistency. This work starts from the need to have measurements of environment concentration of VOC’s to assess the health risk and take decisions regarding public and private policies, since they require information about levels of population exposure to contaminants, number of people exposed, length of exposition, and the knowledge of quantitative relationships between exposition and effects on health. In this short communication we inform about the results of a year of continuous monitoring of VOC’s in the micro center of the city of Cordoba.
Clinical and Epidemiological Profile of Herpes Zoster; A Cross-Sectional Study from Tertiary Hospital
Authors: Paudel Vikash , Pandey Buddhi Raj , Tripathee Richa , Tripathee Rishabh Dev , Sitaula Shreema , Dhakal Prabin , Shrestha Dwarika Prasad 
Published: August 2018

Background: Herpes zoster is dermatomal neuropathic disease caused by reactivation of varicella zoster virus, characterized by vesicobullous eruptions. Although, being a common cause of morbidity, there are few clinicepidemiological studies and the studies regarding the knowledge and practice among the patients are nominal.Methods: This was descriptive observational study which included 100 consecutive patients with herpes zoster who presented to Department of Dermatology and Venereology in a Teaching Hospital, Kathmandu during the period from July 2014 to June 2015.Results: The annual incidence was 0.55%. Seventy two percent were males and 28 percent were females with the M: F=2.5:1. The average age of patients and mean duration of disease was 40.4 years and 5.5 days respectively. Ninety five percent were managed at OPD and 5 % of them needed hospitalization. Most common dermatome involved was thoracic (50%) followed by cervical (20%). Twelve percent had one or more provocative features including diabetes, steroid use, chemotherapy, surgical trauma etc. Twenty patients had definite history chicken pox. Twenty-five percent had local complication at the time of presentation. Fifty two percent had themselves identified the lesion as herpes zoster. However, only 10 had some knowledge about it. Twelve percent had visited traditional healers prior to hospital arrival.Conclusions: The results show varied clinicoepidemiologic patterns of herpes zoster. Major patient have less knowledge about it. A larger study would be necessary for better clinical, epidemiological and social behavioral data. Because of ignorance and tradition, awareness program should be conducted to reduce potential complications. Med Phoenix. Vol. 3, Issue. 1, 2018, Page: 60-65
Opis śmierci Juliana Apostaty w wybranych źródłach chrześcijańskich i pogańskich (IV-V w.)
Authors: Piechocka-Kłos Maria 
Published: August 2018

W niniejszym artykule przedstawiono opis śmierci Flawiusza Klaudiusza Juliana (Flavius Claudius Iulianus, 361-363), przez późniejszych pisarzy chrześcijańskich ogłoszonego Apostatą, zamieszczony w wybranych źródłach chrześcijańskich i pogańskich, pochodzących głównie z IV i V w. Wiodącymi wątkami badawczymi były okoliczności śmierci cesarza oraz próba ustalenia jego zabójcy. Najważniejszymi źródłami z tego okresu, wybranymi przez autorkę, do poznania tego zagadnienia, były: Mowa na cześć Juliana i Mowa w obronie świątyń autorstwa Libaniosa z Antiochii (314-395), Historia Kościoła Sokratesa Scholastyka (ok. 380-ok. 450), Historia Kościoła Sozomena (ok. 400-ok. 450) oraz Historia Armenii Faustusa z Bizancjum (IV/V w.). W tych właśnie pismach na temat śmierci Juliana prawdziwe informacje przeplatają się z legendami. Działo się tak dlatego, że nagła śmierć cesarza podczas jego kampanii perskiej, która dosięgła go z rąk nieznanych sprawców, z pewnością sprzyjała spekulacjom oraz tworzeniu się na ten temat opowieści.
Mobilność akademicka jako fenomen „drenażu mózgów” we współczesnym szkolnictwie wyższym
Authors: Kyvliuk Olga , Svyrydenko Denys 
Published: August 2018

Autorzy zbadali wyzwania „drenażu mózgów” w kontekście realizacji idei mobilności akademickiej w ukraińskim systemie szkolnictwa wyższego. Problem zbadany został pod względem dwóch pozycji metodologicznych. Po pierwsze, w kontekście ogólnoświatowych trendów globalizacji, co pozwoliło umieścić badany problem w skali światowej. Po drugie, w kontekście postkolonialnych (posttotalitarnych itp.), społeczno-kulturowych uwarunkowań dzisiejszej Ukrainy, który pozwolił uchwycić specyficzny wymiar badanego problemu. Na podstawie przeprowadzonych analiz autorzy wskazali kierunki do dalszych badań fenomenu utraty kapitału społecznego, który jest istotnym skutkiem realizowania programów mobilności akademickiej.
Krajobraz szkolnictwa jako wypadkowa koncepcji edukacji
Authors: Terepyshchyi Serhii 
Published: August 2018

W artykule przeprowadzono analizę zależności krajobrazu szkolnictwa od przyjętej koncepcji edukacji. Zostały opisane cechy, które charakteryzują rzeczywistość edukacyjną: elastyczność, dynamiczność, antropologiczność, przestrzenność, kompozycyjność, semantyczność, symboliczność, temporalność, rytmiczność, hybrydowość, kontekstualność, sytuacyjność. Krajobraz szkolnictwa został ukazany także jako ważne zjawisko społeczne, ogniskujące się wokół trzech wymiarów: podmiotowego („jednostki”), interpodmiotowego („społeczeństwa”) i symbolicznego („kultury”). Wyodrębniono również pięć głównych podejść do edukacji: indywidualne, typologiczne, metaforyczne, konstruktywistyczne oraz mitologiczne. Wskazano perspektywy dalszych badań w zakresie typologii oraz metod analizy krajobrazów szkolnictwa.
Designing Information Product (IP) Maps On the Process of Data Processing and Academic Information
Authors: Effendi Diana 
Published: August 2018

Information Product Approach (IP Approach) is an information management approach. It can be used to manage product information and data quality analysis. IP-Map can be used by organizations to facilitate the management of knowledge in collecting, storing, maintaining, and using the data in an organized. The process of data management of academic activities in X University has not yet used the IP approach. X University has not given attention to the management of information quality of its. During this time X University just concern to system applications used to support the automation of data management in the process of academic activities. IP-Map that made in this paper can be used as a basis for analyzing the quality of data and information. By the IP-MAP, X University is expected to know which parts of the process that need improvement in the quality of data and information management.

Index term: IP Approach, IP-Map, information quality, data quality.
REFERENCES[1] H. Zhu, S. Madnick, Y. Lee, and R. Wang, “Data and Information Quality Research: Its Evolution and Future,” Working Paper, MIT, USA, 2012.[2] Lee, Yang W; at al, Journey To Data Quality, MIT Press: Cambridge, 2006.[3] L. Al-Hakim, Information Quality Management: Theory and Applications. Idea Group Inc (IGI), 2007.[4] “Access : A semiotic information quality framework: development and comparative analysis : Journal ofInformation Technology.” [Online]. Available: http://www.palgravejournals.com/jit/journal/v20/n2/full/2000038a.html. [Accessed: 18-Sep-2015].[5] Effendi, Diana, Pengukuran Dan Perbaikan Kualitas Data Dan Informasi Di Perguruan Tinggi MenggunakanCALDEA Dan EVAMECAL (Studi Kasus X University), Proceeding Seminar Nasional RESASTEK, 2012, pp.TIG.1-TI-G.6.
A FILIAÇÃO SOCIOAFETIVA E SEUS REFLEXOS NO ORDENAMENTO JURÍDICO BRASILEIRO
Authors: Siqueira Tamiris Aparecida Rangel , Pinto Ricardo Spinelli 
Published: August 2018

O objetivo do presente trabalho é analisar a relevância da filiação socioafetiva e discutir os reflexos do seu reconhecimento no sistema jurídico brasileiro. Devido às mudanças sociais ocorridas na sociedade, o Direito de Família passou a valorizar os laços afetivos existentes entre pais e filhos, e passou a reconhecer uma nova modalidade de filiação, a filiação socioafetiva. Filiação socioafetiva é aquela filiação pautada na convivência familiar, na solidariedade, no amor entre pais e filhos, sem que exista necessariamente vínculo biológico ou jurídico entre eles. Apresenta-se em diversas situações, como na adoção legal, na adoção à brasileira, nos filhos de criação e nos filhos provenientes de técnicas de reprodução assistida heteróloga. A pesquisa foi desenvolvida através do estudo teórico de doutrinas, e de jurisprudências a respeito do tema em pauta. O reconhecimento da filiação socioafetiva gera efeitos pessoais e efeitos que vão além da relação entre pais e filhos, como no caso da inelegibilidade do filho socioafetivo. Assim, o Supremo Tribunal Federal reconheceu a repercussão geral do tema da prevalência ou não dessa modalidade de filiação. A criação da Lei 11.924/2009 que autorizou o acréscimo do patronímico do padrasto ou madrasta no registro de nascimento é um reflexo que a filiação socioafetiva ocasionou na legislação. E a multiparentalidade, é uma direção que aos poucos tem sido tomada pelos operadores de direitos a fim de dar efetividade a todos os laços afetivos existentes no âmbito familiar.
O PROCESSO DE INSERÇÃO DE PESSOAS COM NECESSIDADES ESPECIAIS NO MERCADO DE TRABALHO
Authors: Ribeiro Geisiane Tassinari , Ferreira André , Rodrigues Luiz Carlos 
Published: August 2018

Este artigo tem como objetivo identificar, por meio de estudo de caso, as dificuldades na contratação de mão de obra com necessidades especiais, as ações empreendidas e o que ainda necessita ser feito por uma empresa, situada no Sul Fluminense, visando se adequar e cumprir os requisitos da Lei de Cotas. Na revisão teórica, aborda-se a definição de deficiência e seus tipos para que se enquadrem na lei de reserva de vagas no mercado de trabalho, a legislação que assegura os direitos das pessoas com necessidades especiais e as técnicas de recrutamento, seleção e práticas de retenção de PcNE. Para a coleta de dados, foram aplicados de questionários a 8 gestores e 8 colegas de trabalho de funcionários deficientes e reabilitados, e realizada entrevistas com os responsáveis das áreas de relações industriais, recrutamento e seleção e medicina do trabalho. Os resultados indicam que as práticas atuais realizadas pela empresa para a inclusão social são mínimas e objetivam apenas o cumprimento da Lei de Cotas, verificando-se também que não há campanhas de socialização ou integração dos funcionários com deficiência com os demais setores da organização. Concluiu-se, a partir dos dados coletados, que é necessário um processo organizacional que estimule a quebra de preconceitos e sensibilização da sociedade da qual a PcNE está inserido, e que incluir pessoas com deficiência no mercado de trabalho deve ser um processo planejado e ocorrer de dentro para fora da organização.
A Criterion for the Onset of Chaos in Systems of Two Eccentric Planets
Authors: Hadden Sam , Lithwick Yoram 
Published: August 2018

Abstract
We derive a criterion for the onset of chaos in systems consisting of two massive, eccentric, coplanar planets. Given the planets’ masses and separation, the criterion predicts the critical eccentricity above which chaos is triggered. Chaos occurs where mean motion resonances overlap, as in Wisdom's pioneering work. But whereas Wisdom considered the overlap of first-order resonances only, limiting the applicability of his criterion to nearly circular planets, we extend his results to arbitrarily eccentric planets (up to crossing orbits) by examining resonances of all orders. We thereby arrive at a simple expression for the critical eccentricity. We do this first for a test particle in the presence of a planet and then generalize to the case of two massive planets, based on a new approximation to the Hamiltonian. We then confirm our results with detailed numerical simulations. Finally, we explore the extent to which chaotic two-planet systems eventually result in planetary collisions.
Effect of the Inclusion of the Metacarpophalangeal Joints on the Wrist Magnetic Resonance Imaging Scoring System in Juvenile Idiopathic Arthritis
Authors: van Dijkhuizen E.H. Pieter , Vanoni Federica , Magnano Gian Michele , Magnaguagno Francesca , Rosendahl Karen , van Rossum Marion A. , Martini Alberto , Malattia Clara ,   and the OMERACT Working Group MRI in JIA
Published: August 2018

Objective.To extend the magnetic resonance imaging (MRI) score for assessment of wrist synovitis in juvenile idiopathic arthritis (JIA) by inclusion of the metacarpophalangeal (MCP) joints, and to compare the metric properties of the original and the extended score.Methods.Wrist MRI of 70 patients with JIA were scored by 3 independent readers according to (1) the wrist component of the rheumatoid arthritis MRI synovitis score (comprising distal radioulnar, radiocarpal, and combined midcarpal and carpometacarpal joints); and (2) an extended score including the MCP joints. Thirty-eight patients had a 1-year MRI followup. The concordance between the readers [intraclass correlation coefficient (ICC), 95% limits of agreement (LOA), and weighted Cohen’s κ], correlations with clinical variables (Spearman’s ϱ), and the sensitivity to change [standardized response mean (SRM)] were calculated for both scores.Results.The interreader agreement was moderate for the original score (ICC 0.77; 95% CI 0.68–0.84) and good for the extended score (ICC 0.86; 95% CI 0.80–0.91). Using 95% LOA, the aggregate score variability was less favorable with relatively wide LOA. Weighted Cohen’s κ of the individual joints indicated good agreement for the original score and good to excellent agreement for the extended score. Correlations with clinical variables reflecting disease activity improved for the extended score and its SRM was higher compared to that of the original score.Conclusion.The extended score showed better reliability, construct validity, and sensitivity to change than the original. Inclusion of the MCP joints should be considered for a more accurate assessment of disease activity and treatment efficacy in JIA.
Rheumatological Assessment Is Important for Interstitial Lung Disease Diagnosis
Authors: Levi Yair , Israeli-Shani Lilach , Kuchuk Michael , Epstein Shochet Gali , Koslow Matthew , Shitrit David 
Published: August 2018

Objective.Interstitial lung diseases (ILD) form a diverse group of parenchymal lung disorders. Currently, a multidisciplinary team (MDT) including pulmonologists, radiologists, and pathologists is the gold standard for ILD diagnosis. Recently, additional subtypes of connective tissue disease (CTD)-ILD with autoimmune features were defined, making the rheumatological assessment increasingly important. We aimed to assess the effect of adding a rheumatologist to the MDT for routine rheumatology assessment.Methods.A prospective study that assessed newly diagnosed ILD patients by 2 parallel blinded arms; all patients were evaluated by both MDT (e.g., history, physical examination, blood tests, pulmonary function tests, and biopsies, if needed) and a rheumatologist (e.g., history, physical examination, blood and serological tests).Results.Sixty patients were assessed with the mean age of 67.3 ± 12 years, 55% male, and 28% smokers. The rheumatological assessment reclassified 21% of the idiopathic pulmonary fibrosis as CTD. Moreover, the number of CTD-ILD with autoimmune features was increased by 77%. These included antineutrophil cytoplasmic antibody–associated vasculitis, antisynthetase syndrome, and IgG4-related ILD. Retrospectively, rheumatological evaluation could have saved 7 bronchoscopies and 1 surgical biopsy.Conclusion.Adding routine rheumatology assessments could significantly increase diagnostic accuracy and reduce invasive procedures.
IL-21 Selectively Protects CD62L+ NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy
Authors: Ngai Ho , Tian Gengwen , Courtney Amy N. , Ravari Soodeh B. , Guo Linjie , Liu Bin , Jin Jingling , Shen Elise T. , Di Pierro Erica J. , Metelitsa Leonid S. 
Published: August 2018

Abstract
T cells expressing CD19-specific chimeric Ag receptors (CARs) produce high remission rates in B cell lymphoma, but frequent disease recurrence and challenges in generating sufficient numbers of autologous CAR T cells necessitate the development of alternative therapeutic effectors. Vα24-invariant NKTs have intrinsic antitumor properties and are not alloreactive, allowing for off-the-shelf use of CAR-NKTs from healthy donors. We recently reported that CD62L+ NKTs persist longer and have more potent antilymphoma activity than CD62L− cells. However, the conditions governing preservation of CD62L+ cells during NKT cell expansion remain largely unknown. In this study, we demonstrate that IL-21 preserves this crucial central memory–like NKT subset and enhances its antitumor effector functionality. We found that following antigenic stimulation with α-galactosylceramide, CD62L+ NKTs both expressed IL-21R and secreted IL-21, each at significantly higher levels than CD62L− cells. Although IL-21 alone failed to expand stimulated NKTs, combined IL-2/IL-21 treatment produced more NKTs and increased the frequency of CD62L+ cells versus IL-2 alone. Gene expression analysis comparing CD62L+ and CD62L− cells treated with IL-2 alone or IL-2/IL-21 revealed that the latter condition downregulated the proapoptotic protein BIM selectively in CD62L+ NKTs, protecting them from activation-induced cell death. Moreover, IL-2/IL-21–expanded NKTs upregulated granzyme B expression and produced more TH1 cytokines, leading to enhanced in vitro cytotoxicity of nontransduced and anti–CD19-CAR–transduced NKTs against CD1d+ and CD19+ lymphoma cells, respectively. Further, IL-2/IL-21–expanded CAR-NKTs dramatically increased the survival of lymphoma-bearing NSG mice compared with IL-2–expanded CAR-NKTs. These findings have immediate translational implications for the development of NKT cell–based immunotherapies targeting lymphoma and other malignancies.
Human Lymph Nodes Maintain TCF-1hi Memory T Cells with High Functional Potential and Clonal Diversity throughout Life
Authors: Miron Michelle , Kumar Brahma V. , Meng Wenzhao , Granot Tomer , Carpenter Dustin J. , Senda Takashi , Chen Dora , Rosenfeld Aaron M. , Zhang Bochao , Lerner Harvey , Friedman Amy L. , Hershberg Uri , Shen Yufeng , Rahman Adeeb , Luning Prak Eline T. , Farber Donna L. 
Published: August 2018

Abstract
Translating studies on T cell function and modulation from mouse models to humans requires extrapolating in vivo results on mouse T cell responses in lymphoid organs (spleen and lymph nodes [LN]) to human peripheral blood T cells. However, our understanding of T cell responses in human lymphoid sites and their relation to peripheral blood remains sparse. In this study, we used a unique human tissue resource to study human T cells in different anatomical compartments within individual donors and identify a subset of memory CD8+ T cells in LN, which maintain a distinct differentiation and functional profile compared with memory CD8+ T cells in blood, spleen, bone marrow, and lungs. Whole-transcriptome and high-dimensional cytometry by time-of-flight profiling reveals that LN memory CD8+ T cells express signatures of quiescence and self-renewal compared with corresponding populations in blood, spleen, bone marrow, and lung. LN memory T cells exhibit a distinct transcriptional signature, including expression of stem cell–associated transcription factors TCF-1 and LEF-1, T follicular helper cell markers CXCR5 and CXCR4, and reduced expression of effector molecules. LN memory T cells display high homology to a subset of mouse CD8+ T cells identified in chronic infection models that respond to checkpoint blockade immunotherapy. Functionally, human LN memory T cells exhibit increased proliferation to TCR-mediated stimulation and maintain higher TCR clonal diversity compared with memory T cells from blood and other sites. These findings establish human LN as reservoirs for memory T cells with high capacities for expansion and diverse recognition and important targets for immunotherapies.
Semi-volatile and highly oxygenated gaseous and particulate organic compounds observed above a boreal forest canopy
Authors: Lee Ben H. , Lopez-Hilfiker Felipe D. , D'Ambro Emma L. , Zhou Putian , Boy Michael , Petäjä Tuukka , Hao Liqing , Virtanen Annele , Thornton Joel A. 
Published: August 2018

Abstract. We present hourly online observations of molecular compositions (CxHyOzN0−1) and abundances of oxygenated organic species in gas and submicron particle phases from April to June of 2014 as part of the Biogenic Aerosols-Effects on Cloud and Climate (BAECC) campaign. Measurements were made using the Filter Inlet for Gases and AEROsols coupled to a high-resolution time-of-flight iodide-adduct ionization mass spectrometer (FIGAERO-CIMS) located atop a 35 m tall tower, about 10 m above a boreal forest canopy at the SMEAR II research station in Hyytiälä, Finland. Semi-volatile and highly oxygenated multifunctional (HOM) organic species possessing from 1 up to 20 carbon atoms, and with as few as 2 and as many as 16 oxygen atoms, were routinely observed. Utilizing non-negative matrix factorization, we determined that > 90 and > 99 % of the organic mass in the gas and particle phases, respectively, exhibited one of three distinct diel trends: one in which abundances were enhanced at daytime, another in the early morning hours, and thirdly during nighttime. Particulate organic nitrates contributed  ∼  35 % to the total organic aerosol mass loading at night during BAECC, much higher than observed by the same instrument package at a mixed-deciduous forest site in the southeastern US that experienced higher nighttime concentrations of nitrogen oxides. Unique HOM monomers (defined here as those with 10 carbon and 7 or more oxygen atoms) and dimers (at least 16 carbon atoms), with and without a nitrogen atom, were found in most of the three subgroups of both phases. We show the potential to connect these groupings of compounds based on their distinct behavior in time to the expected chemical conditions (biogenic VOC precursor, oxidant type, etc.) responsible for their production. A suite of nitrated dimer-like compounds was detected in both the gas and particle phases, suggesting a potential role for the formation of low-volatility organics from NO3-radical-driven, as well as daytime NO-influenced, monoterpene chemistry.