bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognosis of Transcatheter Closure Compared with Surgical Repair of Paravalvular Leak after Prosthetic Valve Replacement: A Retrospective Comparison
Authors: Yang Chun , Liu Yang , Tang Jiayou , Jin Ping , Li Lanlan , Yu Shiqiang , Yang Jian 
Published: May 2018

Abstract
Objective Paravalvular leak (PVL) after valve replacement remains clinically challenging. Percutaneous closure is an effective therapy for patients with PVLs because reoperation is associated with high rates of morbidity and mortality. The purpose of this study was to retrospectively compare the clinical outcome of transcatheter closure and surgical repair in patients with a PVL.
Methods From January 2000 to May 2016, 131 patients with PVL were treated at three major medical centers in China. Perioperative characteristics and outcomes of the procedure were reviewed.
Results Sixty-eight (51.9%) patients with PVLs were treated with percutaneous transcatheter closure (group I). The procedure was successful in 67 (98%) with no hospital deaths. Sixty-three (48.1%) patients with PVLs had a reoperation (group II). Five of the surgical patients had a third open-heart operation for residual regurgitation, and one underwent successful percutaneous closure. Six patients died in the hospital postoperatively. All patients in group II but only 11 in group I needed perioperative blood transfusions. The procedural time and hospital stay after the procedure were significantly shorter in group I than in group II. At the 1-year follow-up, cardiac function improved by ≥ 1 New York Heart Association functional class in 55 (82%) patients in group I and in 39 (68%) patients in group II.
Conclusions Transcatheter closure was shown to be a safe, effective therapeutic option in patients with PVL. It was associated with a lower hospital mortality rate, shorter procedural time, and fewer blood transfusions than surgical treatment in selected patients.
Efficacy of Miniuniportal Video-Assisted Thoracoscopic Selective Sympathectomy (Ramicotomy) for the Treatment of Severe Palmar and Axillar Hyperhidrosis
Authors: Akil Ali , Semik Michael , Fischer Stefan 
Published: May 2018

Background Video-assisted thoracoscopic surgery (VATS) clipping of the sympathetic branch has become the standard approach for the treatment of essential hyperhidrosis when conservative treatment failed. However, this is associated with relevant potential complications such as postoperative compensatory sweating and recurrent sweating. We report the outcome after selective sympathectomy (ramicotomy) through a miniuniportal VATS approach in patients with therapy-refractory palmar and/or axillary hyperhidrosis.
Methods A total of 51 consecutive patients (37 females, mean age: 30 years, range: 12–64 years) who suffered from therapy-refractory palmar and/or axillary severe hyperhidrosis were included. Data were prospectively collected and retrospectively analyzed. All patients underwent bilateral miniuniportal VATS ramicotomy. Duration of surgery, hospital stay, recurrent, and compensatory sweating were documented.
Results All patients had palmar sweating, where 51% had additional axillary sweating and 57% had additional plantar sweating. In all patients, selective division of the rami communicantes of the thoracic sympathetic ganglions Th2 to Th5 was performed. The mean duration of bilateral surgery for both sides was 67 ± 2.5 minutes. The mean postoperative hospital stay was 2 ± 1 days. After surgery and at further follow-up (mean: 12 ± 2.5 months), all patients presented dry and warm hands and axillae, without any evidence of compensatory or recurrent sweating. All patients described a remarkable increase in quality of life.
Conclusion Miniuniportal VATS ramicotomy represents a feasible surgical technique with a very high success and satisfaction rate. Therefore, this approach should be considered as the method of choice for the treatment of patients with severe therapy-refractory palmar and axillary hyperhidrosis.
From Mitten Hand to Five Individual Fingers: One-Stage Coverage Using a Deep Inferior Epigastric Perforator Free Flap for an Extensive Degloving Hand Injury
Authors: Kim Min Ji , Park Bo Young 
Published: May 2018

AbstractCoverage of hands with degloving injuries is currently being investigated, but it typically involves combinations of free flap operations to cover wide dimensions. In this study, the deep inferior epigastric perforator (DIEP) flap was successfully used to salvage a severely injured hand. After performing an open wound coverage with a flap operation, we did several minimal division operations under local anesthesia, which is a logical surgical option when the patient suffers from general deterioration immediately following significant trauma. We believe that this application of DIEP flap allows for a shorter operation time, decreased rates of infection for one-step coverage, and a higher chance of functional digit division compared with conventional methods.
Mediating the contributions of Facebook to political participation in Italy and the UK: the role of media and political landscapes
Authors: Casteltrione Isidoropaolo , Pieczka Magda 
Published: May 2018

AbstractOver the last decade, an increasing number of academic studies have examined how digital technologies can contribute to political participation, with numerous publications focusing on social networking websites. This article adds to this strand of research by tackling the scarcity of cross-national comparative studies in the field. Drawing from an original dataset acquired by combining a cross-national comparative approach and a mixed-methods methodology, this paper explores how media and political landscapes mediate the contributions of Facebook to citizens’ political participation in Italy and the United Kingdom. A participatory gap between Italian and British participants, with Italians displaying higher levels of political participation through Facebook, is found and explained with reference to three contextual factors: the greater diffusion and relevance of other online platforms such as Twitter in the UK; Italian participants’ more negative perception of traditional media linked to the high level of political parallelism typical of the Italian media system; and the presence in Italy of a political party such as the Five Stars Movement making full use of the communicative and organizational affordances of Facebook. The findings indicate that the contributions of Facebook, and digital technologies in general, to political participation must be analysed in context, within the larger patterns they fit into, and cannot be examined in isolation. Such contributions are better understood if considered within the hybrid media system in which different digital platforms interact, merge and compete. Similarly, the political scenarios in which citizens and political parties operate need to be accounted for when looking at the links between the Internet and politics.
Upper and lower body responses to repeated cyclical sprints
Authors: Halperin Israel , Collins Brandon W. , Monks Michael , Compton Chris T. , Yetman Joseph D. , Loucks‐Atkinson Angela , Basset Fabien , Button Duane C. 
Published: May 2018

AbstractPurpose: To compare the physiological and perceptual responses of the upper and lower body to all‐out cyclical sprints with short or long rest periods between sprints.Methods: Ten recreationally trained males completed four 10 × 10 s sprint protocols in a randomized order: upper body with 30 s and 180 s of rest between sprints, and lower body with 30 s and 180 s of rest between sprints. Additionally, maximum voluntary contractions (MVC) were measured at pre‐sprint and post‐sprints 5 and 10. Normalized (% of first sprint) peak power, MVC, heart rate (HR) and rating of perceived exertion (RPE) were compared between upper and lower body within the same recovery period, and absolute values (Watts, bpm, RPE scores) were compared within the same body part and between recovery periods.Results: Trivial differences were identified in normalized peak power, HR and RPE values between the upper and lower body in both recovery conditions (<2%, d ≤ 0.1), but MVC forces were better maintained with the upper body (∼9.5%, d = 1.0) in both recovery conditions. Absolute peak power was lower (∼147 Watts, d = 1.3), and HR was higher (∼10 bpm, d = 0.73) in the 30 s compared to 180 s condition in both the upper and lower body whereas RPE scores were similar (<0.6 RPE units, d ≤ 0.1). Despite the reductions in peak power, MVC forces were better maintained in the 30 s condition in both upper (2.5 kg, d = 0.4) and lower (7.5 kg, d = 0.7) body.Conclusions: Completing a commonly used repeated sprint protocol with the upper and lower body results in comparable normalized physiological and perceptual responses.
The revival of the Gini importance?
Authors: Nembrini Stefano , König Inke R , Wright Marvin N 
Published: May 2018

Abstract

Motivation
Random forests are fast, flexible and represent a robust approach to analyze high dimensional data. A key advantage over alternative machine learning algorithms are variable importance measures, which can be used to identify relevant features or perform variable selection. Measures based on the impurity reduction of splits, such as the Gini importance, are popular because they are simple and fast to compute. However, they are biased in favor of variables with many possible split points and high minor allele frequency.

Results
We set up a fast approach to debias impurity-based variable importance measures for classification, regression and survival forests. We show that it creates a variable importance measure which is unbiased with regard to the number of categories and minor allele frequency and almost as fast as the standard impurity importance. As a result, it is now possible to compute reliable importance estimates without the extra computing cost of permutations. Further, we combine the importance measure with a fast testing procedure, producing p-values for variable importance with almost no computational overhead to the creation of the random forest. Applications to gene expression and genome-wide association data show that the proposed method is powerful and computationally efficient.

Availability and implementation
The procedure is included in the ranger package, available at https://cran.r-project.org/package=ranger and https://github.com/imbs-hl/ranger.

Supplementary information
Supplementary data are available at Bioinformatics online.
FlexiDot: highly customizable, ambiguity-aware dotplots for visual sequence analyses
Authors: Seibt Kathrin M , Schmidt Thomas , Heitkam Tony 
Published: May 2018

Abstract

Summary
FlexiDot is a cross-platform dotplot suite generating high quality self, pairwise and all-against-all visualizations. To improve dotplot suitability for comparison of consensus and error-prone sequences, FlexiDot harbors routines for strict and relaxed handling of ambiguities and substitutions. Our shading modules facilitate dotplot interpretation and motif identification by adding information on sequence annotations and sequence similarities. Combined with collage-like outputs, FlexiDot supports simultaneous visual screening of large sequence sets, enabling dotplot use for routine analyses.

Availability and implementation
FlexiDot is implemented in Python 2.7. Software and documentation are freely available at http://github.com/molbio-dresden/flexidot.

Supplementary information
Supplementary data are available at Bioinformatics online.
tp53-dependent and independent signaling underlies the pathogenesis and possible prevention of Acrofacial Dysostosis–Cincinnati type
Authors: Watt Kristin E N , Neben Cynthia L , Hall Shawn , Merrill Amy E , Trainor Paul A 
Published: May 2018

AbstractRibosome biogenesis is a global process required for growth and proliferation in all cells, but disruptions in this process surprisingly lead to tissue-specific phenotypic disorders termed ribosomopathies. Pathogenic variants in the RNA Polymerase (Pol) I subunit POLR1A cause Acrofacial Dysostosis–Cincinnati type, which is characterized by craniofacial and limb anomalies. In a zebrafish model of Acrofacial Dysostosis–Cincinnati type, we demonstrate that polr1a–/– mutants exhibit deficient 47S rRNA transcription, reduced monosomes and polysomes and, consequently, defects in protein translation. This results in Tp53-dependent neuroepithelial apoptosis, diminished neural crest cell proliferation and cranioskeletal anomalies. This indicates that POLR1A is critical for rRNA transcription, which is considered a rate limiting step in ribosome biogenesis, underpinning its requirement for neuroepithelial cell and neural crest cell proliferation and survival. To understand the contribution of the Tp53 pathway to the pathogenesis of Acrofacial Dysostosis–Cincinnati type, we genetically inhibited tp53 in polr1a–/– mutant embryos. Tp53 inhibition suppresses neuroepithelial apoptosis and partially ameliorates the polr1a mutant phenotype. However, complete rescue of cartilage development is not observed due to the failure to improve rDNA transcription and neural crest cell proliferation. Altogether, these data reveal specific functions for both Tp53-dependent and independent signaling downstream of polr1a in ribosome biogenesis during neural crest cell and craniofacial development, in the pathogenesis of Acrofacial Dysostosis–Cincinnati type. Furthermore, our work sets the stage for identifying Tp53-independent therapies to potentially prevent Acrofacial dysostosis–Cincinnati type and other similar ribosomopathies.
Consumer Spending and Property Taxes
Authors: Surico Paolo , Trezzi Riccardo 
Published: May 2018

AbstractA sudden and temporary change to the Italian property tax system in 2011 generated significant variation in the amount of taxes paid across home-owners. Using new questions appositely added to the Survey on Household Income and Wealth, we exploit this cross-sectional variation to provide an unprecedented analysis of the consumption effects of a tax on housing wealth. A tax hike on the main dwelling leads to large expenditure cuts among mortgagors, who hold low liquid wealth despite owning sizable illiquid assets. In contrast, higher tax rates on other residential properties affect affluent households, thereby having a modest impact on their consumer spending. Our results provide novel and direct evidence in favor of recent theories that highlight the role of household debt in the transmission of economic policies.
Prison Staff and Prisoner Views on a Prison Smoking Ban: Evidence From the Tobacco in Prisons Study
Authors: Brown Ashley , Sweeting Helen , Logan Greig , Demou Evangelia , Hunt Kate 
Published: May 2018

Abstract

Introduction
In jurisdictions permitting prisoner smoking, rates are high (c75%), with smoking embedded in prison culture, leading to secondhand smoke exposures among staff and prisoners and challenges for smoking cessation. Momentum is building to ban smoking in prisons, but research on staff and prisoner views is lacking. We address this gap, providing evidence on staff and prisoner views throughout all Scottish prisons.

Methods
Data were collected prior to the announcement of a (November 2018) prison smoking ban throughout Scotland. Mixed methods were used: surveys of staff (online, N = 1271, ~27%) and prisoners (questionnaire, N = 2512, ~34%); 17 focus groups and two paired interviews with staff in 14 prisons.

Results
Staff were more positive than prisoners about bans and increased smoking restrictions, although prisoner views were more favorable should e-cigarettes be permitted. Nonsmokers were more positive than smokers. Whilst 74% staff and 22% prisoners agreed bans were a good idea, both groups acknowledged implementation and enforcement challenges. Staff views were influenced by beliefs about: acceptability of the policy in principle and whether/how bans could be achieved. Although some voiced doubts about smoke-free policies, staff likened a ban to other operational challenges. Staff raised concerns around needs for appropriate measures, resources and support, adequate lead-in time, and effective communication prior to a ban.

Conclusion
We recommend that regular and open opportunities for dialogue within and between different stakeholder groups are created when preparing for prison smoking bans and that specific measures to address staff and prisoner concerns are incorporated into plans to create and maintain smoke-free environments.

Implications
To our knowledge, this study is the first to research staff and prisoner views across a whole prison system prior to implementation of smoke-free policies. The results highlight potential challenges and suggest measures, which might help to maximize the success of bans. Our results are relevant for prison service managers responsible for the forthcoming introduction of a ban in Scottish prisons (November 2018) and for other prison systems and comparable institutions planning smoke-free initiatives. Given that prison smoking bans may be contentious, we recommend creating regular and open opportunities for dialogue between stakeholders when preparing for and maintaining smoke-free environments.
Continuity between koniocellular layers of dorsal lateral geniculate and inferior pulvinar nuclei in common marmosets
Authors: Huo Bing-Xing , Zeater Natalie , Lin Meng Kuan , Takahashi Yeonsook S. , Hanada Mitsutoshi , Nagashima Jaimi , Lee Brian C. , Hata Junichi , Grünert Ulrike , Miller Michael I. , Rosa Marcello G.P. , Okano Hideyuki , Martin Paul R. , Mitra Partha P. 
Published: May 2018

AbstractIn primates, the koniocellular (K) layers of the dorsal lateral geniculate nucleus (LGN) and the calbindin-rich subdivisions of the inferior pulvinar (IPul) nucleus are considered part of a thalamic matrix system which projects diffusely to superficial cortical layers. Activity in the matrix system is proposed to coordinate oscillatory activity in thalamocortical loops. Further, since both K cells and IPul are involved in visual processing pathways, especially in alternative pathways to visual cortex after V1 lesion in early life (“blindsight”), their functional similarities have been strongly implicated. Here we tested the hypothesis that calbindin-positive K cells and IPul cells constitute a continuous group of cells. By combining immunohistochemistry and a high-throughput neuronal tracing method, we found that both K cells and IPul form reciprocal connections with striate and extrastriate cortices; whereas principal laminae of LGN do not receive inputs from extrastriate cortex and only project sparsely to these areas. Retrograde labelled cells in lateral division of IPul merged seamlessly into the retrograde labelled cells in K layers. These results supported the continuity between LGN K layers and IPul, providing the anatomical basis for functional congruity of this part of dorsal thalamic matrix.
Bayesian Multi-SNP Genetic Association Analysis: Control of FDR and Use of Summary Statistics
Authors: Lee Yeji , Luca Francesca , Pique-Regi Roger , Wen Xiaoquan 
Published: May 2018

AbstractMulti-SNP genetic association analysis has become increasingly important in analyzing data from genome-wide association studies (GWASs) and molecular quantitative trait loci (QTL) mapping studies. In this paper, we propose novel computational approaches to address two outstanding issues in Bayesian multi-SNP genetic association analysis: namely, the control of false positive discoveries of identified association signals and the maximization of the efficiency of statistical inference by utilizing summary statistics. Quantifying the strength and uncertainty of genetic association signals has been a long-standing theme in statistical genetics. However, there is a lack of formal statistical procedures that can rigorously control type I errors in multi-SNP analysis. We propose an intuitive hierarchical representation of genetic association signals based on Bayesian posterior probabilities, which subsequently enables rigorous control of false discovery rate (FDR) and construction of Bayesian credible sets. From the perspective of statistical data reduction, we examine the computational approaches of multi-SNP analysis using z-statistics from single-SNP association testing and conclude that they likely yield conservative results comparing to using individual-level data. Built on this result, we propose a set of sufficient summary statistics that can lead to identical results as individual-level data without sacrificing power. Our novel computational approaches are implemented in the software package, DAP-G (https://github.com/xqwen/dap), which applies to both GWASs and genome-wide molecular QTL mapping studies. It is highly computationally efficient and approximately 20 times faster than the state-of-the-art implementation of Bayesian multi-SNP analysis software. We demonstrate the proposed computational approaches using carefully constructed simulation studies and illustrate a complete workflow for multi-SNP analysis of cis expression quantitative trait loci using the whole blood data from the GTEx project.
Ionizing radiation induces stem cell-like properties in a caspase-dependent manner in Drosophila
Authors: Verghese Shilpi , Su Tin Tin 
Published: May 2018

ABSTRACTCancer treatments including ionizing radiation (IR) can induce cancer stem cell-like properties in non-stem cancer cells, an outcome that can interfere with therapeutic success. Yet, we understand little about what consequences of IR induces stem cell like properties and why some cancer cells show this response but not others. In previous studies, we identified a pool of epithelial cells in Drosophila larval wing discs that display IR-induced stem cell-like properties. These cells are resistant to killing by IR and, after radiation damage, change fate and translocate to regenerate parts of the disc that suffered more cell death. Here, we addressed how IR exposure results in the induction of stem cell-like behavior, and found a requirement for caspase activity. Unexpectedly, this requirement was mapped to the regenerative cells, suggesting a non-apoptotic role for caspases in the induction of stem cell-like behavior. We also performed a systematic probing of different regions of the wing disc by lineage tracing, in order to identify additional pools of cells with IR-induced regenerative properties. We identified two new populations of such cells. Unlike the original pool that helps regenerate the disc, the new pools of cells undergo abnormal regeneration to produce an ectopic, supernumerary wing disc. We also identified cells that lack the ability to display IR-induced regenerative behavior. Identification of different cell populations with different IR-induced regenerative potential will allow us to probe the molecular basis for these differences in the future.AUTHOR SUMMARYIonizing Radiation (IR), alone or in combination with other therapies, is used to treat an estimated half of all cancer patients. Yet, we understand little about why some tumors cells respond to treatment while others grow back (regenerate). We identified specific pools of cells within a Drosophila organ that are capable of regeneration after damage by IR. We also identified what it is about IR damage that allows these cells to regenerate. These results help us understand how cells regenerate after IR damage and will aid in designing better therapies that involve radiation.