bluuebunny/crossref_metadata_2025_split huggingface dataset:
TUJUAN NEGARA DALAM ISLAM MENURUT YUSUF AL-QARADHAWI
Authors: Abdullah Sigit Ridwan 
Published: March 2019

AbstractYusuf al-Qaradawi is one of the figures of so many scholars who contributed to the thinking of the Islamic state. His attention to politics and state is evidenced by the presence of some of his works such as الإسلام في الدولة فقه من (Fiqh of State in Islamic Perspective), الشرعية السياسة (Political Sharia), الإسلام مواجهة في العلماني التطرف (Extreme Secular Attitudes towards Islam), وهم لا حقيقة اللإسلامية اللأمة (The Political Unit of Ummah is a Reality). This research tried to review Yusuf al-Qaradawi's view on Islamic state, using descriptive analytical methods and literature review upon the above stated Yusuf al-Qaradawi's books or writings. The research result shows that Islamic state according to Yusuf al-Qaradawi is "a state based on faith and thought." He stated that there are four objectives of Islamic government. Firstly, Islamic Government does not aim to control the nation and its natural resources, but to preserve and protect the people. Secondly, fulfill the mandate from the owner. Thirdly, uphold justice for the human race. Fourthly, strengthen the religion in the earth as the most important goal by establishing faith, hudud and applying the law and its messages.Keywords: Islamic State, State aims, Yusuf al-QaradhawiAbstrakYusuf al-Qaradhawi merupakan salah satu tokoh dari begitu banyak tokoh pemikir yang turut memberikan kontribusi pemikiran tentang negara Islam. Perhatiannya terhadap politik dan kenegaraan terbukti dengan adanya beberapa karya beliau seperti bukuمن فقه الدولة في الإسلام (Fiqih Negara dalam Perspektif Islam), السياسة الشرعية (Politik Syariah), التطرف العلماني في مواجهة الإسلام (Sikap Sekuler Ekstrim dalam Menghadapi Islam), اللأمة اللإسلامية حقيقة لا وهم (Kesatu­an Politik Ummat Islam adalah Suatu Kenyataan). Penelitian ini menganalisis pandangan Yusuf al-Qaradhawi terhadap negara Islam dengan menggunakan metode deskriptif analitis dalam bentuk library research, terhadap buku-buku atau tulisan lepas Yusuf al-Qaradhawi tersebut di atas. Negara Islam menurut Yusuf al-Qaradhawi adalah “negara yang berlandas­kan akidah dan pemikiran.” Ia menyatakan bahwa ada empat tujuan pemerintah­an Islam yaitu: Pertama, Pemerintahan Islam tidak bertujuan untuk menguasai lahir batin, tetapi untuk memelihara dan melindungi rakyat. Kedua, menunaikan amanat kepada pemiliknya. Ketiga, menegakan keadilan bagi ummat manusia. Keempat, mengo­koh­kan agama di muka bumi sebagai tujuan yang paling utama dengan menanam­­kan akidah, hudud dan mengaplikasikan hukum dan pesan-pesan­nya.Kata kunci: Negara Islam, tujuan negara, Yusuf al-Qaradhawi
Activity and the density of rheumatologists in Russian Federation, 2013-2017
Authors: Son I. M. , Ivanova M. A. , Sokolovskaya T. A. , Liutsko V. V. , Dezhurny L. I. 
Published: March 2019

The incidence of noncommunicable diseases is one of the problems for the health of the population. In this regard, an adequate supply of rheumatologists and other specialists is necessary for timely providing medical care to the population.Aim. To analyze the current state of the provision of rheumatologists and their activities in the Russian Federation.Material and methods. Used data of Federal statistical observation over the period from 2013 to 2017, the paper used statistical, analytical, descriptive methods of statistics.Results. This article presents an analysis of the data of official statistics on the rheumatologists’ density. The results indicate the stability of the situation in this specialty, although in general there was a decrease in the staffing of outpatient clinics.Conclusion. Study showed a decrease in specialists staffing and stable situation on the density of outpatient departments of medical organizations.
First-in-Human Phase I Study of Merestinib, an Oral Multikinase Inhibitor, in Patients with Advanced Cancer
Authors: He Aiwu Ruth , Cohen Roger B. , Denlinger Crystal S. , Sama Ashwin , Birnbaum Ariel , Hwang Jimmy , Sato Takami , Lewis Nancy , Mynderse Michelle , Niland Michele , Giles Jennifer , Wallin Johan , Moser Brian , Zhang Wei , Walgren Richard , Plimack Elizabeth R. 
Published: March 2019

Abstract

Background
The purpose of this nonrandomized, open-label, phase I study (NCT01285037) was to evaluate the safety and tolerability of merestinib, an oral antiproliferative and antiangiogenic kinase inhibitor, and to determine a recommended phase II dose and schedule for patients with advanced cancer.

Materials and Methods
This was a multicenter, nonrandomized, open-label, phase I study of oral merestinib consisting of six parts: dose escalation (part A), followed by a four-cohort dose-confirmation study (part B) and subsequently a four-part dose expansion and combination safety testing of merestinib with standard doses of cetuximab (part C), cisplatin (part D), gemcitabine and cisplatin (part E), and ramucirumab (part F) in patients with specific types of advanced cancers. Safety, tolerability, antitumor activity, and pharmacokinetics were evaluated in all cohorts.

Results
The dose escalation, confirmation, and expansion results support the dosing of merestinib at 120 mg once daily, based on acceptable exposure and safety at this dose. One complete response was observed in a patient with cholangiocarcinoma, and three patients with cholangiocarcinoma achieved a partial response. Overall, 60 (32%) of the 186 patients enrolled in the study had a best response of stable disease.

Conclusion
This study demonstrates that merestinib has a tolerable safety profile and potential anticancer activity and warrants further clinical investigation.

Implications for Practice
Merestinib treatment in patients with advanced cancer demonstrated an acceptable safety profile and potential antitumor activity, supporting its future development in specific disease populations as a monotherapy and/or in combination with other therapies.
PENGARUH MOTIVASI BERPRESTASI DAN KOMPETENSI TERHADAP KINERJA GURU
Authors: Nugraha Nugraha 
Published: March 2019

Penelitian ini berlatar belakang munculnya fenomena yang menunjukkan bahwa sertifikasi guru yang bertujuan meningkatkan kompetensi sekaligus kesejahteraan guru ternyata tidak sesuai dengan yang diharapkan. Guru yang telah lolos sertifikasi ternyata tidak menunjukkan peningkatan kompetensi yang signifikan. Faktor yang mempengaruhi kinerja tersebut diantaranya motivasi berprestasi dan kompetensi. Penelitian ini menggunakan metode survey dengan pendekatan kuantitatif. Populasi berjumlah 225 orang dan sampel berjumlah 155 orang. Hasil dari penelitian ini adalah motivasi berprestasi guru (X1) berpengaruh secara langsung terhadap kompetensi guru (X2) sebesar 0,6630, motivasi berprestasi guru (X1) terhadap kinerja guru (Y) berpengaruh langsung sebesar 0,4020 dan pengaruh tidak langsungnya yang melalui kompetensi guru (X2) sebesar 0,1833. Pengaruh dari kompetensi guru (X2) terhadap kinerja guru secara langsung sebesar 0,5672.
PENGARUH EFISIENSI MODAL KERJA TERHADAP PROFITABILITAS PADA PERUSAHAAN TEKSTIL DAN GARMEN
Authors: Novianty Dinni Endah 
Published: March 2019

Penelitian ini bertujuan untuk mengetahui pengaruh efisiensi modal kerja terhadap profitabilitas pada Perusahaan Tekstil dan Garmen yang Terdaftar di Bursa Efek Indonesia periode 2011-2014, dimana efisiensi modal kerja diukur menggunakan Working Capital Turnover (WCT), dan profitabilitas diukur menggunakan Return on Investment (ROI). Metode penelitian yang digunakan adalah metode deskriptif dan verifikatif. Adapun teknik pengumpulan data yang digunakan adalah metode dokumentasi. Data berupa laporan keuangan dan laporan tahunan yang diperoleh dari situs resmi Bursa Efek Indonesia. Populasi dalam penelitian ini adalah 18 perusahaan tekstil dan garmen yang terdaftar di Bursa Efek Indonesia (BEI) periode 2011-2014. Teknik pengambilan sampel menggunakan purposive sampling, dengan seluruh anggota populasi dijadikan sampel. Pengolahan data dalam penelitian ini menggunakan perhitungan statistik regresi linier sederhana. Sebelum melakukan analisis regresi linier sederhana, dilakukan normalitas dan uji linieritas. Selanjutnya, dilakukan pengujian regresi menggunakan uji F, kemudian dilanjutkan dengan pengujian keberartian koefisien regresi dengan menggunakan uji t. Berdasarkan hasil pengolahan statistik diperoleh persamaan regresi WCT. Melalui pengujian hipotesis, persamaan regresi tersebut menunjukkan bahwa efisiensi modal kerja berpengaruh positif terhadap profitabilitas dengan koefisien sebesar . Artinya, apabila efisiensi modal kerja mengalami kenaikan sebanyak satu kali maka profitabilitas pun akan meningkat sebesar kali. Kata Kunci: Efisiensi Modal Kerja, Profitabilitas
PENGARUH PROFITABILITAS DAN SOLVABILITAS TERHADAP HARGA SAHAM PADA EMITEN SEKTOR PROPERRTY DAN REAL ESTATE DI BURSA EFEK INDONESIA
Authors: Faruk Umar 
Published: March 2019

Penelitian ini bertujuan untuk mengetahui: (1) gambaran profitabilitas emiten sektor property dan real estate di BEI tahun 2010, (2) gambaran solvabilitas emiten sektor property dan real estate di BEI tahun 2010, (3) gambaran harga saham emiten sektor property dan real estate di BEI tahun 2011, (4) pengaruh profitabilitas terhadap harga saham saham pada emiten sektor property dan real estate di BEI tahun 2011, (5) pengaruh solvabilitas terhadap harga saham pada emiten sektor property dan real estate di BEI tahun 2011 dan (6) pengaruh profitabilitas dan solvabilitas terhadap harga saham pada emiten sektor property dan real estate di BEI tahun 2011. Profitabilitas diukur melalui Return on Assets (ROA), dan solvabilitas diukur menggunakan Debt to Equity Ratio (DER). Metode penelitian yang digunakan adalah metode deskriptif verifikatif. Sampel penelitian ini adalah seluruh emiten property dan real estate yang terdaftar di BEI serta aktif menerbitkan laporan keuangan selama tahun pengamatan, yaitu sebanyak 40 emiten. Pengumpulan data dilakukan dengan cara mengambil dokumentasi laporan keuangan dari BEI dan diolah menggunakan uji statistik regresi linier berganda. Berdasarkan hasil penelitian dapat diketahui: (1) secara umum profitabilitas sektor property dan real estate memiliki nilai ROA yang rendah, oleh karena itu harus bisa lebih meningkatkan kinerja, sehingga memperoleh laba yang tinggi, (2) secara umum solvabilitas perusahaan sektor property dan real estate masih terdapat beberapa perusahaan yang memiliki hutang yang tinggi sehingga memiliki rata-rata yang tinggi,(3) secara umum harga saham sektor property dan real estate masih masih rendah karena masih terdapat perusahaan yang memiliki harga saham dibawah rata-rata sektoral, (4) profitabilitas berpengaruh positif terhadap harga saham pada sektor property dan real estate tahun 2011, (5) Solvabilitas tidak berpengaruh terhadapa harga saham pada sektor property dan real estate dan (6) profitabilitas dan solvabilitas berpengaruh terhadap harga saham pada emiten sektor property dan real estate. Kata Kunci: Sektor Property dan Real Estate, Profitabilitas (ROA), Solvabilitas (DER) dan Harga Saham.
PENGARUH PENGGUNAAN MODUL PADA PEMBELAJARAN MATERI PENCATATAN TRANSAKSI PERUSAHAAN MANUFAKTUR TERHADAP HASIL BELAJAR SISWA SMKN 1 SURABAYA
Authors: Rochmawati Rochmawati 
Published: March 2019

Studi penelitian ini bertujuan untuk mengetahui pengaruh penggunaan modul pada pembelajaran materi pencatatan transaksi perusahaan manufaktur terhadap hasil belajar siswa SMKN 1 Surabaya. Jenis penelitian ini adalah penelitian kuantitatif. Populasi dalam penelitian ini adalah seluruh siswa kelas XII Akuntansi SMKN 1 Surabaya. Sampel dalam penelitian ini adalah kelas XII AK3 sebanyak 39 siswa sebagai kelas eksperimen dan kelas XII AK1 sebanyak 40 siswa sebagai kelas kontrol. Teknik pengumpulan data menggunakan tes dan angket pendapat siswa. Teknik analisis data menggunakan uji t test. Hasil analisis data dengan t-test menunjukkan bahwa nilai equal variances assumed dengan nilai T hitung sebesar 9,398 lebih besar daripada t-tabel yaitu 1.66488 dengan signifikansi 0,000≤0,005. Hal ini menunjukkan bahwa terdapat perbedaan hasil belajar antara siswa yang diberi perlakuan pemberian modul dengan siswa yang tidak diberi perlakuan pemberian modul materi pencatatan transaksi perusahaan manufaktur terhadap hasil belajar siswa SMKN 1 Surabaya. Berdasarkan hasil perbedaan tersebut maka dapat disimpulkan bahwa terdapat pengaruh penggunaan modul pada pembelajaran materi pencatatan transaksi perusahaan manufaktur terhadap hasil belajar siswa SMKN 1 Surabaya. Kata Kunci: Pembelajaran, Modul, Hasil Belajar
PENGARUH KINERJA KEUANGAN TERHADAP HARGA SAHAM BANK UMUM KONVENSIONAL DI BURSA EFEK INDONESIA PADA TAHUN 2013-2016
Authors: Yuliyanti Leni 
Published: March 2019

Penelitian ini bertujuan untuk mengetahui pengaruh kinerja keuangan yang terbagi kedalam empat komponen rasio keuangan yaitu permodalan, risiko kredit, risiko likuiditas, dan rentabilitas terhadap harga saham bank umum konvensional di Bursa Efek Indonesia tahun 2013-2016. Permodalan dalam penelitian ini diukur dengan menggunakan Capital Adequacy Ratio (CAR), risiko kredit diukur dengan menggunakan Non Performing Loan (NPL), risiko likuiditas diukur dengan menggunakan Loan to Deposit Ratio (LDR), rentabilitas diukur dengan menggunakan Return On Asset (ROA), sedangkan harga saham dalam penelitian ini diukur melalui harga saham penutupan tahunan. Metode penelitian yang digunakan dalam penelitian ini adalah metode deskriptif dan verifikatif. Purposive sampling digunakan untuk menentukan sampel penelitian dengan jumlah sampel sebanyak 10 bank selama 4 tahun penelitian. Analisis statistik yang digunakan dalam penelitian ini adalah analisis regresi linier multipel data panel. Berdasarkan hasil pengujian keberartian koefisien regresi (Uji F) menunjukkan bahwa model regresi dapat digunakan untuk mengambil suatu kesimpulan. Sedangkan hasil uji t menunjukkan bahwa permodalan berpengaruh positif terhadap harga saham, risiko kredit berpengaruh negatif terhadap harga saham, rentabilitas berpengaruh positif terhadap harga saham, risiko likuiditas berpengaruh positif tidak signifikan terhadap harga saham. Kata Kunci : Permodalan, risiko kredit, risiko likuiditas, harga saham
The effect of hormone replacement therapy on cognitive function in postmenopausal women: An RCT
Authors: Moradi Fereshteh , Jahanian Sadatmahalleh Shahideh , Ziaei Saeideh 
Published: March 2019

Background: During the reproductive age, the human brain becomes a target for gonadal steroid hormones. Estrogens influence neural function through effects on neurons and affects indirectly the oxidative stress, inflammation, the cerebral vascular and the immune system.
Objective: To evaluate the effect of the traditional hormone replacement therapy (HRT) on the cognitive function in postmenopausal women.
Materials and Methods: In this randomized clinical trial, 140 postmenopausal women, from November 2014 to February 2015, were included. Women were randomly divided into two groups. Each woman in the case group took traditional HRT (0.625mg conjugated equine estrogens+2.5mg medroxyprogesterone acetate daily) plus one Cal+D tablet (500 mg calcium+200 IU vitamin D) daily for four months. Women in the control group received only one Cal+D tablet (500 mg calcium+200 IU vitamin D) daily for four months period. The Montreal Cognitive Assessment (MoCA) and Green Climacteric Scale (GCS) questionnaires filled out after the intervention and compared between the two groups.
Results: The mean points of the MoCA after the intervention indicate that all MoCA domains except for the orientation improved in the case group. There was a significant difference in the memory domain after the treatment between the two groups. MoCA domains and GCS were negatively correlated after the intervention (r = −0.235, p = 0.006).
Conclusion: The HRT has affected some of the MoCA factors. The effects of HRT on cognitive function should be studied in a large prospective study in a group of women in their early and late menopausal ages with periodic assessment of their cognitive function during these follow-up years.
Key words: Streptococcus agalactiae, Iran, Pregnancy, Prevalence, Female.Key words: Cognition, Hormone replacement therapy, Postmenopausal women.
Increased expression of stemness genes Rex-1, Oct-4, Nanog, and Sox-2 in women with ovarian endometriosis versus normal endometrium: A case-control study
Authors: Shariati Fatameh , Favaedi Raha , Ramazanali Fariba , Ghoraeian Pegah , Afsharian Parvaneh , Aflatoonian Behrouz , Aflatoonian Reza , Shahhoseini Maryam 
Published: March 2019

Background: Endometriosis is a common, chronic inflammatory disease which is defined as an overgrowth of endometrial tissue outside the uterine cavity. The etiology of this disease is complex and multifactorial but there is a strong evidence that supports the presence of endometrial stem cells and their possible involvement in endometriosis.
Objective: In this study, we analyzed the mRNA expression of REX-1 stemness gene and reconsidered three other stemness genes SOX-2, NANOG, OCT-4 in women with endometriosis compared to normal endometrium.
Materials and Methods: Ten ectopic and ten eutopic tissue samples along with 23 normal endometrium specimens were recruited in this study. The expression levels of OCT-4, NANOG, SOX-2, and REX-1 genes were evaluated by the quantitative real-time polymerase chain reaction.
Results: The transcription levels of OCT-4, NANOG, and SOX-2 mRNA were significantly increased in ectopic lesions compared with eutopic and control group (p = 0.041, p = 0.035, p = 0.048), although the REX-1 mRNA increase was not significant between endometriosis and control groups. Also, there were differences in the expression level of these genes in normal endometrium during the menstrual cycles (p = 0.031, p = 0.047, p = 0.031).
Conclusion: Based on our data, we confirm the dynamic role of stemness genes in proliferation and growth of normal endometrium during the menstrual cycle and conclude that differential expression n levels of these genes may contribute to the pathophysiology of endometriosis.
Key words: Endometriosis, Stemness genes.
The protective effect of vitamin C on phenylhydrazine-induced hemolytic anemia on sperm quality and in-vitro embryo development in mice
Authors: Karimipour Mojtaba , Dibayi Zahra , Ahmadi Abass , Zirak Javanmard Masoumeh , Hosseinalipour Elnaz 
Published: March 2019

Background: Phenylhydrazine (PHZ) induced anemia and was shown to have harmful effects on the male reproductive system.
Objective: To investigate the protective effect of vitamin C (Vit C) on sperm parameters quality, in vitro fertilization potential and embryonic development in a mouse model of hemolytic anemia induced by PHZ.
Materials and Methods: Thirty-two NMRI adult male mice (n = 8/each) were randomly classified into four groups. Group I (control) received normal saline, Group II (PHZ) received 8 mg/100 gr body weight PHZ as initial dose, continued by 6 mg/100 gr intraperitoneally every 48 hr, Group III (Vit C) received Vit C (10 mg/kg, daily, intraperitoneally), and group IV (PHZ + Vit C) received PHZ and Vit C. After 35 days, sperm quality parameters, the percentage of sperm with DNA damage and in vitro fertilization outcomes up to blastocyst stage were evaluated.
Results: A significant (p < 0.001) reduction in all of the sperm parameters (count, motility, viability and normal morphology) were observed in group II (PHZ) compared with group I (control). In group IV (PHZ ± Vit C), these parameters and sperm DNA damage (p < 0.001) improved significantly when compared with PHZ-treated mice. Furthermore, PHZ caused a significant (p < 0.001) decrease in the fertilization rate and the percentage of pre implantation embryos’ (two cell embryo and blastocyst) formation in comparison to group I (control), and Vit C supplementation in mice of group IV improved significantly the fertilization rate (p = 0.002), but it could not improve the percentage of two cell embryos and blastocyst production.
Conclusion: The data from this study indicated that Vit C decreased the adverse effects of PHZ on the quality of sperm parameters and in vitro fertilization rate, but it is insufficient to restore the in-vitro embryonic development and fertility potential.
Key words: Vitamin C, Phenylhydrazine, Sperm, Fertilization, Mice.
La dignidad humana como fundamento de la identidad europea: la labor del Tribunal Europeo de Derechos Humanos en la delimitación de la noción de dignidad humana
Authors: Ochoa Ruiz Natalia 
Published: March 2019

La construcción de la identidad europea requiere identificar y analizar las raíces comunes de Europa para establecer, sobre esta base, un proyecto común, basado en unos principios, valores y objetivos compartidos. Entre estos principios y valores adquiere una importancia primordial la dignidad humana. Pese a no encontrarse formulada en el Convenio de Roma de 1950, el Tribunal Europeo de Derechos Humanos, a través de su jurisprudencia, ha realizado una importante contribución a su reconocimiento y garantía. En el presente trabajo, se analiza la jurisprudencia del Tribunal con el fin de identificar cuál es el fundamento y contenido de la dignidad humana y se apunta la necesidad de una reflexión sosegada sobre esta cuestión por sus implicaciones sobre el concepto mismo de ser humano.Recibido: 02 julio 2018 Aceptado: 10 septiembre 2018 Publicación en línea: 27 febrero 2019
TINJAUAN AL-QUR’AN DAN PRINSIP PEMBEBANAN DALAM PENENTUAN DIMENSI KESTABILAN PONDASI BANGUNAN
Authors: Sedayu Agung 
Published: March 2019

Foundation is a part of building construction having function continuously to support entire or all the building burden to ground. One of the factor of buildingcon truction should be supported by the sturdy foundation, and sturdy foundation depend on his compiler composition and dimension of foundation. Therefore it is needed tire calculations of foundation so that we get well guaranted of his stability. Besides that, ground factor also have stability of structure, because the ground sustain the foundation and place where burden given by foundation. Power factor support the ground against the foundation action is highly varied, it is _depend on composition and nature of ground, information concerning energy number support of this ground can be shown passing investigation _of ground. To guarantee security in a building one of the among others is to looking for comparison between foundations and well-balanced ground. The dimension of foundation must be enough and fit with the power of ground. Detennination of building foundation is very influenced by energy support the ground. And energy support the ground depict strength of ground to accepted burden. Energy support the ground is very influenced by character, nature, type, structure, formation, and component compiler of ground, besides also usage of foundation type is also influenced by contour, ground water face and topography. Energy support the ground explained by some concept or theories, among others is Terzaghi theory and accepted encumbering principle or apply at the foundation structure. From both this concept determinable of enough and stable dimension of strength sustain a building. The foundation dimension is reckoned by the minimum or smallest measure or dimension, but have ever been optimal to sustain the burden befall it.