bluuebunny/crossref_metadata_2025_split huggingface dataset:
T cell activation triggers reversible inosine-5′-monophosphate dehydrogenase assembly
Authors: Duong-Ly Krisna C. , Kuo Yin-Ming , Johnson Matthew C. , Cote Joy M. , Kollman Justin M. , Soboloff Jonathan , Rall Glenn F. , Andrews Andrew J. , Peterson Jeffrey R. 
Published: August 2018

ABSTRACT
T cell-mediated adaptive immunity requires naïve, unstimulated T cells to transition from a quiescent metabolic state into a highly proliferative state upon T cell receptor engagement. This complex process depends on transcriptional changes mediated by Ca2+-dependent NFAT signaling, mTOR-mediated signaling and increased activity of the guanine nucleotide biosynthetic inosine-5′-monophosphate (IMP) dehydrogenase 1 and 2 enzymes (IMPDH1 and IMPDH2, hereafter IMPDH). Inhibitors of these pathways serve as potent immunosuppressants. Unexpectedly, we discovered that all three pathways converge to promote the assembly of IMPDH protein into micron-scale macromolecular filamentous structures in response to T cell activation. Assembly is post-transcriptionally controlled by mTOR and the Ca2+ influx regulator STIM1. Furthermore, IMPDH assembly and catalytic activity were negatively regulated by guanine nucleotide levels, suggesting a negative feedback loop that limits biosynthesis of guanine nucleotides. Filamentous IMPDH may be more resistant to this inhibition, facilitating accumulation of the higher GTP levels required for T cell proliferation.
Development of the Enhanced Halsey Model to Predict Equilibrium Moisture Content (EMC) of Sunflower Seeds with Different Oil Contents
Authors: Maciel Gisele , De la Torre Diego A. , Cendoya María Gabriela , Izquierdo Natalia G. , Bartosik Ricardo E. 
Published: August 2018

Abstract. Using the right equilibrium moisture content (EMC) relationship is critical for implementing successful aeration strategies and for determining the safe storage moisture content of grains and oilseeds. The oil content of sunflower seeds substantially affects the moisture equilibrium relationship, implying that a specific set of model parameters for each oil content range should be obtained. To overcome this practical limitation, the Enhanced Halsey model was developed incorporating a new parameter (D) to characterize the effect of oil content on the original Modified Halsey model. The constants A, B, C, and D of the model were obtained for a wide range of temperatures, moisture and oil contents. The simplicity of the Enhanced Halsey model and the possibility of adapting EMC as a function of oil content make the Enhanced Halsey model valuable for engineering applications (e.g., aeration controllers) and for predicting the safe storage moisture content of seeds with different oil contents, such as sunflower. Keywords: Composition, Grain, Isotherms, Oilseed, Relative humidity, Sorption, Storage quality.
SEASONAL FLUCTUATIONS IN THE SURFACE SALINITY OFF THE NORTH COAST OF JAVA
Authors: Soeriaatmadja Raden E. 
Published: August 2018

The division of the region investigated according to P. CH. VEEN is redescribed. The micro salinity titration by means of the method described by G. H. ARNOLD with an accuracy of 0.1 ‰ was used for this investigation. This technique was adopted because of the large number of observations, and was sufficiently accurate since salinity in these waters varies widely. The annual range in salinity is large, caused by a considerable discharge of fresh water from the many big and small rivers, especially in the rainy-season as well as by the inequality of salinity of the oceanwaters coming from the East, and the South China Sea water coming from the West, during the dry and wet-sason respectively. In the east-monsoon, the eastern section is covered with ocean water over 34.0 ‰ and the western section with mixed waters ranging between 31.5 ‰ and 34.0 ‰, while in the west-monsoon, the area is covered with mixed water less than 32.5 ‰.
SURFACE SALINITIES IN THE STRAIT OF MALACCA
Authors: Soeriaatmadja Raden E. 
Published: August 2018

A continuous northwest-going current prevails in the Strait of Malacca throughout the year, except June and August, when the currents are very weak and sometimes reversed in the .southern part. The southern part of the Strait of Malacca is influenced by the currents. These currents transport low saline water into the Strait during the southwest monsoon and high saline water from the South China Sea during the northeast monsoon. In the northern part, the rainfall is of greater importance for the variations of the surface salinity and a strong correlation between rainfall and surface salinities is found in this region. It is unlikely that Indian Ocean water penetrates the South China Sea.
SEASONAL FLUCTUATIONS IN THE SURFACE SALINITY ALONG THE COAST OF THE SOUTHERN PART OF KALIMANTAN (BORNEO)
Authors: Sjarif Sjarmilah 
Published: August 2018

The westerly current of the Java Sea from the southeast is branched to the north, along the eastcoast of Kalimantan (Borneo) as far as Cape Mangkalihat. This current brings high saline water, over 34.0 ‰, and increases the salinity along the coast of the southern part of Kalimantan, working together with the decreasing rains. In the westmonsoon, when the westward current has retreated and the easterly current from the South China Sea has developed, the northerly current along the eastcoast is replaced by a southerly current, from ,the Pacific. Under influence of the increasing rains and the large outflow of the rivers in the southern part of Kalimantan the salinity decreases rapidly, until a minimum value. This minimum is found irregularly during the diffferent months of the westmonsoon or the succeeding transition period. The lowest values are found in Sukadana Bay (29.0 ‰) and off Bandjarmasin (± 24.0 ‰). The further from this place, the higher the values. The maximum salinity is found during the months September and October in accordance with the minimum rainfall. The highest values are found in the eastern part of the investigated area (34.5 ‰). To the west it is lower, the more it is mixed with the low-saline water of the Java Sea. The salinity in the Karimata Strait is about 33.0 to 33.5 ‰.
E-GOVERNMENT SEBAGAI LAYANAN KOMUNIKASI PEMERINTAH KOTA SURABAYA (Studi Kematangan e-government Sebagai Layanan Komunikasi Government to Government, Government to Citizen, Government to Business)
Authors: Noveriyanto Baharudin , Nisa Laila Chairun , Bahtiar Achmad Sofian , Sahri Sahri , Irwansyah Irwansyah 
Published: August 2018

Fenomena pergeseran media komunikasi kearah IoT (Internet of Things) sebagai salah satu model komunikasi saat ini harus disikapi positif oleh pemerintah daerah untuk bisa berinovasi untuk meningkatkan performance organisation management and public service improvement. e-government adalah sebuah bentuk media komunikasi, dimana media didefinisikan sebagai “The Extension of Man” (media itu perluasan manusia). Dengan menggunakan metode deskriptif analisis dan studi literature dengan focus penelitian pada Dinas Komunikasi dan Informatika Kota Surabaya selaku pemegang amanat untuk mengelola informasi dan dokumentasi teknologi informasi di lingkungan pemerintahan Kota Surabaya sesuai dengan keputusan Walikota Surabaya Nomor: 188.45/24/436.1.2/2015. menghasilkan tingkat kematangan e-government di Kota Surabaya telah memenuhi pemeringkatan pada level 4. Sehingga sudut pandang ilmu komunikasi mengatakan, tingkat kematangan layanan e-governemen sebagai media komunikasi government to government, government to citizen, government to business. dimana media adalah “The Extension of Man”, Dengan tujuan kemudahan dalam melakukan komunikasi maka layanan e-government diharapkan dapat menjadi media komunikasi untuk mempercepat pertukaran informasi, menyediakan sarana layanan dan kegiatan transaksi dengan warga masyarakat (G2C), kepada pelaku bisnis (G2B), dan tentunya dengan pihak pemerintah sendiri (G2G)The phenomenon of communication media shift towards IoT (Internet of Things) as one of the current communication model must be responded positively by local government to be able to innovate to improve organizatin management and public service improvement performance. e-government is a form of communication media, in which the media is defined as "The Extension of Man" (the medium is human extension). By using descriptive method of analysis and literature study with focus of research at Surabaya City Communications and Informatics Office as the holder of the mandate to manage information and documentation of information technology in Surabaya city government in accordance with the decision of Mayor of Surabaya Number 188.45 / 24 / 436.1.2 / 2015. resulted in the maturity level of e-government in the city of Surabaya has fulfilled the ranking at level 4. So the perspective of communication science said, the maturity level of e-governemen service as a medium of communication between government to government, government to citizen, government to business. where the media is "The Extension of Man", With the purpose of ease of communication, e-government services are expected to become a medium of communication to accelerate the exchange of information, provide facilities and activities of transactions with citizens (G2C), to the business (G2B) , and certainly with the government itself (G2G)
TANTANGAN SOCIOPRENEURS YOGYAKARTA DI ERA COMMUNICATION 3.0
Authors: Purwani Diah Ajeng , Partini Partini , Wastutiningsih Sri Peni 
Published: August 2018

Social enterprise pada dasarnya merupakan organisasi sosial yang mempunyai misi berkelanjutan, dimana para sociopreneurs menjadikan masalah sosial sebagai peluang untuk membantu masyarakat sekitarnya. Di Yogyakarta, aktivitas social entrepreneurship menunjukkan peningkatan setiap tahunnya terutama di kalangan anak muda. Saat ini tren usaha di bidang sosial bukan lagi sebuah keterpaksaan, tetapi menjadi pilihan bagi para pelakunya. Penelitian ini menggunakan teknik deskriptif kualitatif dengan studi kasus tentang sociopreneurs. Penelitian dilakukan untuk mengkaji dan menganalisis tantangan yang dihadapi sociopreneurs Yogyakarta sebagai mitra pembangunan di era communication 3.0.Social enterprise is primarily a social organization that has a sustainable mission, where the social problems make sociopreneurs as an opportunity to help the surrounding community. In Yogyakarta, a social entrepreneurship activity shows an increase every year, especially among the young. Current efforts in the social field are no longer because of forced but became an option for the perpetrators. This research was conducted to review and analyze the challenges facing sociopreneurs Yogyakarta as partners of development in the era of communication 3.0.
Suplementasi Seng untuk Pencegahan Penyakit Infeksi
Authors: Candra Aryu 
Published: August 2018

Seng diperlukan oleh manusia dan hewan untuk melaksanakan fungsi fisiologis, seperti pertumbuhan, kekebalan tubuh, dan reproduksi. Defisiensi seng menyebabkan anoreksia, gangguan pertumbuhan, dermatitis, gangguan pengecapan, dan hipogonadisme. Prevalensi defisiensi seng pada balita di Indonesia belum diketahui dengan pasti, namun diperkirakan cukup tinggi mengingat pola makan balita di Indonesia yang belum sesuai dengan anjuran pedoman gizi seimbang. Dari hasil penelitian awal pada tahun 2016 diketahui bahwa asupan seng pada balita di wilayah kelurahan Jomblang kota Semarang 30% termasuk dalam kategori kurang.Seng juga sangat berperan dalam proses pertumbuhan, perkembangan fungsi kognitif, dan imunitas.. Banyak penelitian yang sudah membuktikan bahwa defisiensi seng dan zat besi menyebabkan gangguan pertumbuhan dan fungsi kognitif. Defisiensi seng juga dapat menurunkan jumlah dan ukuran sel-sel imun, terutama sel T sehingga kekebalan tubuh akan menurun yang menyebabkan balita menjadi lebih mudah terserang penyakit infeksi.Pola makan balita di Indonesia sebagian besar hanya terdiri atas makronutrien yaitu karbohidrat, protein, dan lemak. Hal ini yang menyebabkan munculnya defisiensi mikronutrien pada balita. Oleh karena itu diperlukan suplementasi mikronutrien seperti seng untuk mengatasi defisiensi seng pada balita sehingga dapat meningkatkan imunitas dan mencegah infeksi.
Attitudes Toward Universal Basic Income and Welfare State in Europe: A Research Note
Authors: Lee Soomi 
Published: August 2018

AbstractThis research note examines the relationship between public attitudes toward universal basic income (UBI) and country-level socio-economic conditions in 21 European Countries. Despite abundant theoretical and empirical research on UBI, a comparative analysis of public appetite for UBI has been unavailable due to data limitations. This research note takes advantage of the 2016 European Social Survey to explore the connection between public support for UBI and levels of social protection and economic insecurity.
Food Retail Liberalization, Food Retail Structure and Food Prices: The Italian Case
Authors: Castellari Elena , Bonanno Alessandro , Sckokai Paolo 
Published: August 2018

Abstract
In the last two decades the Italian food retail industry has changed considerably also thanks to the liberalization process started with the 1998 retail regulation reform. In this study, we investigate the impact of such reform on the food and beverage consumer price index, controlling for the endogenous nature of the policy adoption across regions, and addressing what changes in food retail structure may have driven those effects. We find that the policy had a mitigating effect on food prices, which can be explained by the change in the number and composition of food stores operating in the Italian market, rather than by the changes in store size and in-store services. We find the policy effects not to be statistically different across regions characterized by different levels of liberalization.
Will Tort Law Have Its #Me Too Moment?
Authors: Chamallas Martha 
Published: August 2018

AbstractUsing tort law’s treatment of claims for domestic violence and sexual assault as examples, this essay identifies prominent features of a feminist historical approach to law to demonstrate how gender inequality is reproduced over time, despite changes in legal doctrine. When informed by feminist theory, history can function as a critique of past and present regimes of inequality, highlighting the various techniques of exclusion and marginalization that emerge to prevent law from redressing serious, recurring injuries suffered disproportionately by women. The essay explores two such techniques: sexual exceptionalism that treats gender-related torts differently than other harms and the adoption of ostensibly neutral rules that have a disparate impact on women and marginalized groups. The essay speculates as to whether the #MeToo movement can provide the momentum to produce a break from the past, particularly with respect to third-party claims holding employers and other institutional defendants responsible for sexualized harms.
Solar-blind ultraviolet photodetector based on graphene/vertical Ga2O3 nanowire array heterojunction
Authors: He Tao , Zhao Yukun , Zhang Xiaodong , Lin Wenkui , Fu Kai , Sun Chi , Shi Fengfeng , Ding Xiaoyu , Yu Guohao , Zhang Kai , Lu Shulong , Zhang Xinping , Zhang Baoshun 
Published: August 2018

Abstract
In this paper, a solar-blind ultraviolet photodetector (PD) based on the graphene/vertical Ga2O3 nanowire array heterojunction was proposed and demonstrated. To the best of our knowledge, it is the first time that vertical Ga2O3 nanowire arrays have been realized. Ga2O3 nanowires were obtained by thermally oxidizing GaN nanowires grown by molecular beam epitaxy on n-doped Si substrate. Then, a monolayer graphene film was transferred to Ga2O3 nanowires to form the graphene/vertical Ga2O3 nanowire array heterojunction and transparent electrodes. The fabricated device exhibited a responsivity (R) of 0.185 A/W and rejection ratio (R258 nm/R365 nm) of 3×104 at the bias of −5 V. Moreover, the fast response times of this PD were 9 and 8 ms for the rise and decay times under 254 nm illumination, respectively, which are attributed to the unique properties of nanowire arrays and the graphene/vertical Ga2O3 nanowire array heterojunction structure.
Graphene oxide modification for enhancing high-density polyethylene properties: a comparison between solvent reaction and melt mixing
Authors: Graziano Antimo , Jaffer Shaffiq , Sain Mohini 
Published: August 2018

Abstract
Graphene oxide (GO) was chemically modified in xylene with dodecyl amine and hydrazine monohydrate to obtain reduced functionalized graphene oxide (RFGO). Composites of high-density polyethylene (HDPE) and GO were made via solvent reaction, whereas both melt mixing and solvent reaction were used for HDPE-RFGO composites for comparison purposes. Elemental and thermal analysis showed the success of GO modification in grafting amine functionalities onto its structure and restoring most of the original graphene C=C bonds. A significant increase in mechanical properties, thermal stability, and crystallization behavior was observed for HDPE-RFGO (solvent) compared with HDPE and HDPE-GO, proving that homogeneous dispersion of RFGO in the polymer matrix and strong interactions between them resulted in facilitated stress transfer, delayed thermal degradation, and more efficient nucleating effect in inducing the crystal growth of HDPE. A comparison of HDPE-RFGO properties enhancement between the melt mixing method and the solvent reaction method showed that, apart from mechanical behavior, the RFGO contribution was the same, suggesting that the optimization of the ecofriendlier approach (melt) could eventually lead to its total use for the mass production of high-performance, cost-effective, and more environmentally friendly graphene-based thermoplastic polyolefin nanocomposites suitable for highly demanding industrial applications.
Laminar mixing of non-Newtonian fluids in static mixers: process intensification perspective
Authors: Jegatheeswaran Sinthuran , Ein-Mozaffari Farhad , Wu Jiangning 
Published: August 2018

Abstract
Static mixers are widely used in various industrial applications to intensify the laminar mixing of non-Newtonian fluids. Non-Newtonian fluids can be categorized into (1) time-independent, (2) time-dependent, and (3) viscoelastic fluids. Computational fluid dynamics studies on the laminar mixing of viscoelastic fluids are very limited due to the complexity in incorporating the multiple relaxation times and the associated stress tensor into the constitutive equations. This review paper provides recommendations for future research studies while summarizing the key research contributions in the field of non-Newtonian fluid mixing using static mixers. This review discusses the different experimental techniques employed such as electrical resistance tomography, magnetic resonance imaging, planar laser-induced fluorescence, and positron emission particle tracking. A comprehensive overview of the mixing fundamentals, fluid chaos, numerical characterization of fluid stretching, development of pressure drop correlations, and derivations of generalized Reynolds number is also provided in this review paper.
Alteration in cholinesterases, γ-aminobutyric acid and serotonin level with respect to thiamine deficiency in Swiss mice
Authors: Sharma Anupama , Bist Renu 
Published: August 2018

Abstract
Thiamine (vitamin B1), cofactor for various multi-enzyme complexes in energy metabolism, and plays a major role in the synthesis of cholinesterases such as acetylcholinesterase (AChE); butyrylcholinesterase (BChE). Present study deals with the changes in the cholinesterases, γ-aminobutyric acid (GABA) and serotonin in mice brain following thiamine deficiency. Experimental mice (6–8 week old) were made thiamine deficient by intraperitoneal injection of pyrithiamine hydrobromide and fed with thiamine-deficient diet. Animals were divided into three groups, Group I (Control), Group II (thiamine deficient mice for 8 days), and Group III (thiamine deficient mice for 10 days). The higher serotonin level whereas significant decreases in the AChE, BChE and GABA level were recorded in treated groups as compared to control. Hence, vitamin B1 deficiency disturbs the cholinergic system and neurotransmitters levels in brain which may lead to neurodegenerative diseases.
Data Fusion Technique for Bridge Safety Assessment
Authors: Liang Li , Sun Shuang , Li Ming , Li Xin 
Published: August 2018

Abstract
This article proposes a multilevel assessment system tailored to the health condition evaluation of prestressed continuous concrete bridges. The main structure of the assessment system is divided into a prior database and data processing unit. Some of the factors mainly influencing bridge safety, including carbonation, freeze-thaw cycles, steel corrosion, overloading, and temperature, are utilized to form various load cases as a basis for the prior database. To evaluate the bridge safety conditions comprehensively and scientifically, artificial intelligence methods and data fusion techniques based on information entropy, fuzzy analytical hierarchy, and the Dempster-Shafer theory are utilized to establish the data processing unit. An ambient excitation modal test was conducted to verify the numerical model. In situ mechanical responses from monitoring sensors and visual inspection results are fed back to the data processing unit as indicators of the safety grade of the bridge. The novel assessment system proposed here can feasibly and effectively provide support for bridge management and maintenance.
The effect of strength training on muscle cellular stress in prostate cancer patients on ADT
Authors: Nilsen T S , Thorsen L , Kirkegaard C , Ugelstad I , Fosså S D , Raastad T 
Published: August 2018

Background
Androgen deprivation therapy (ADT) for prostate cancer (PCa) is associated with several side effects, including loss of muscle mass. Muscle atrophy is associated with reduced mitochondrial function and increased muscle cellular stress that may be counteracted by strength training. Thus, the aim of this study was to investigate the effect of strength training on mitochondrial proteins and indicators of muscle cellular stress in PCa patients on ADT.

Methods
Men diagnosed with locally advanced PCa receiving ADT were randomised to a strength training group (STG) (n=16) or a control group (CG) (n=15) for 16 weeks. Muscle biopsies were collected pre- and post-intervention from the vastus lateralis muscle, and analysed for mitochondrial proteins (citrate synthase, cytochrome c oxidase subunit IV (COXIV), HSP60) and indicators of muscle cellular stress (heat shock protein (HSP) 70, alpha B-crystallin, HSP27, free ubiquitin, and total ubiquitinated proteins) using Western blot and ELISA.

Results
No significant intervention effects were observed in any of the mitochondrial proteins or indicators of muscle cellular stress. However, within-group analysis revealed that the level of HSP70 was reduced in the STG and a tendency towards a reduction in citrate synthase levels was observed in the CG. Levels of total ubiquitinated proteins were unchanged in both groups.

Conclusion
Although reduced HSP70 levels indicated reduced muscle cellular stress in the STG, the lack of an intervention effect precluded any clear conclusions.