bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a programme to advance scholarly writing
Authors: Rohan Annie , Fullerton Judith 
Published: December 2018

SummaryBackgroundScholarly writing, although central to the completion of doctoral studies, is often not supported by systematic teaching/learning approaches that specifically help students to convey scholarship through writing. The purpose of this project was to promote writing as an essential component of scholarship, provide opportunities for students to develop a self‐awareness of confidence in writing and challenges to writing, and to improve writing competence.MethodsAn innovative set of peer‐supported interventions was embedded within a core foundational course in a Doctor of Nursing Practice (DNP) programme during the first academic semester as part of a continuing quality improvement process to improve DNP student writing. The first curriculum innovation was a substantive writing assignment, in which students exchanged papers with a classmate and were required to critique both writing conventions (e.g. criteria such as punctuation and citation) and structural and thesis‐driven aspects of writing (e.g. criteria such as clarity, organisation and the use of paragraph leading sentences). Students then read their papers aloud, without hesitation while reading, in order to identify any discrepancies between the written words and the audible ‘plain language’ that would be necessary to enhance clarity. The second innovation was an optional writing workshop in which students received coaching from interdisciplinary mentors and from their peers.ResultsEvaluation of the implementation of this innovation suggests that mentorship, peer support and the use of commonly spoken language may be useful tools for improving the writing competencies of DNP students.DiscussionStudents with broad diversity in writing competency, including low levels of proficiency, benefitted from a writing‐enriched curriculum given at the start of the course of study.DNP faculty may not themselves be prepared to mentor students for doctoral‐level writing
Increasing the adsorption capabilitiy of mordenite and Y zeolites via post‐synthesis chemical/physical treatments in order to remove cationic dyes from polluted water
Authors: Esmaeili Samaneh , Zanjanchi Mohammad Ali , Golmojdeh Hossein , Mizani Farhang 
Published: December 2018

AbstractDifferent post‐synthesis approaches were used to increase the adsorption abilities of zeolite mordenite and Y in removal of cationic dye molecules as typical dyestuff pollutants. Various methods including acid leaching, alkaline treatment, dealumination with hexafluorosilicate, sonication and combination of them were employed to alter the porous structure of various types of selected zeolites. The dealumination (due to acid leaching), desilication (due to alkaline treatment) and disintegration (due to shear forces generated by ultrasound waves) were responsible for the alteration of pores size and accessibility in mordenite. Acid leaching combined with irradiation of ultrasound was found to be most effective technique in adsorption of rhodamine B as a large dye molecule into mordenite. In the case of zeolite Y, a chemical treatment with ammonium hexafluorosilicate resulted in considerable improvement of adsorption of rhodamine B.
Hyperhydration-Induced Decrease in Urinary Luteinizing Hormone Concentrations of Male Athletes in Doping Control Analysis
Authors: Athanasiadou Ioanna , Voss Sven Christian , El Saftawy Wesal , Al-Jaber Hind , Dbes Najib , Al-Yazedi Sameera , Samsam Waseem , Mohamed-Ali Vidya , Alsayrafi Mohammed , Valsami Georgia , Georgakopoulos Costas 
Published: December 2018

Low urinary luteinizing hormone (LH) values have been discussed as a marker to detect steroid abuse. However, suppressed LH concentrations related to highly diluted urine samples could be a misleading indication of anabolic steroid abuse. One aim of the present study was to examine the effect of hyperhydration on the interpretation of LH findings during doping control analysis and to investigate different possibilities to correct volume-related changes in urinary LH concentrations. Seven healthy, physically active, nonsmoking White males were examined for a 72-hr period, using water and a commercial sports drink as hyperhydration agents (20 ml/kg body weight). Urine samples were collected and analyzed according to the World Anti-Doping Agency’s technical documents. Baseline urinary LH concentrations, expressed as the mean ± SD for each individual, were within the acceptable physiological range (7.11 ± 5.42 IU/L). A comparison of the measured LH values for both hyperhydration phases (Phase A: 4.24 ± 5.60 IU/L and Phase B: 4.74 ± 4.72 IU/L) with the baseline (“normal”) values showed significant differences (Phase A: p < .001 and Phase B: p < .001), suggesting the clear effect of urine dilution due to hyperhydration. However, an adjustment of urinary LH concentrations by specific gravity based on a reference value of 1.020 seems to adequately correct the hyperhydration-induced decrease on the LH levels.
Ingesting a 12% Carbohydrate-Electrolyte Beverage Before Each Half of a Soccer Match Simulation Facilitates Retention of Passing Performance and Improves High-Intensity Running Capacity in Academy Players
Authors: Rodriguez-Giustiniani Paola , Rollo Ian , Witard Oliver C. , Galloway Stuart D. R. 
Published: December 2018

This study investigated the influence of ingesting a 12% carbohydrate plus electrolyte (CHO-E) solution providing 60 g of carbohydrate before each half of a 90-min soccer match simulation (SMS) protocol on skill performance, sprint speed, and high-intensity running capacity. Eighteen elite academy (age: 18 ± 2 years) soccer players ingested two 250-ml doses (pre-exercise and at halftime) of a 12% CHO-E solution or electrolyte placebo administered in a double-blind randomized cross-over design. During an indoor (artificial grass pitch) SMS, dribbling, passing, and sprint performance were assessed, and blood was drawn for glucose and lactate analysis. High-intensity running capacity was assessed following the SMS. Dribbling speed/accuracy and sprint speed remained unchanged throughout the SMS. Conversely, passing accuracy for both dominant (mean percentage difference [95% confidence interval, CI]: 9 [3, 15]) and nondominant (mean percentage difference [95% CI]: 13 [6, 20]) feet was better maintained during the SMS on CHO-E (p < .05), with passing speed better maintained in the nondominant foot (mean percentage difference [95% CI]: 5.3 [0.7, 9.9], p = .032). High-intensity running capacity was greater in CHO-E versus placebo (mean percentage difference [95% CI]: 13 [6, 20], p = .010). Capillary blood glucose concentration was higher in CHO-E than placebo at halftime (CHO-E: 5.8 ± 0.5 mM vs. placebo: 4.1 ± 0.4 mM, p = .001) and following the high-intensity running capacity test (CHO-E: 4.9 ± 0.4 mM vs. placebo: 4.3 ± 0.4 mM, p = .001). Ingesting a 12% CHO-E solution before each half of a match can aid in the maintenance of soccer-specific skill performance, particularly on the nondominant foot, and improves subsequent high-intensity running capacity.
Improvements in Phase Angle Are Related With Muscle Quality Index After Resistance Training in Older Women
Authors: Nunes João Pedro , Ribeiro Alex S. , Silva Analiza M. , Schoenfeld Brad J. , dos Santos Leandro , Cunha Paolo M. , Nascimento Matheus A. , Tomeleri Crisieli M. , Nabuco Hellen C.G. , Antunes Melissa , Cyrino Letícia T. , Cyrino Edilson S. 
Published: December 2018

The aim of this study was to analyze the association between muscle quality index (MQI) and phase angle (PhA) after a program of progressive resistance training (RT) in older women. Sixty-six older women with previous RT experience (68.8 ± 4.6 years, 156.6 ± 5.3 cm, 66.0 ± 13.0 kg, and 26.7 ± 4.6 kg/m2) underwent 12 weeks of RT (3 ×/week, eight exercises, and 10–15 repetition maximum). Anthropometry, muscular strength (one-repetition maximum tests), and body composition (dual-energy X-ray absorptiometry and spectral bioimpedance) were measured pre- and posttraining. There were observed significant increases for PhA, MQI, muscular strength, muscle mass, and reactance, whereas no significant changes in body fat and resistance were found. A significant correlation was observed between the RT-induced relative changes in PhA and MQI (r = .620). We conclude that improvements in MQI induced by RT are associated with increases in PhA. Therefore, PhA may be a valid tool to track changes in MQI after 12 weeks of RT in older women.
DIVISIBLE SANDPILE ON SIERPINSKI GASKET GRAPHS
Authors: HUSS WILFRIED , SAVA-HUSS ECATERINA 
Published: December 2018

The divisible sandpile model is a growth model on graphs that was introduced by Levine and Peres [Strong spherical asymptotics for rotor-router aggregation and the divisible sandpile, Potential Anal. 30(1) (2009) 1–27] as a tool to study internal diffusion limited aggregation. In this work, we investigate the shape of the divisible sandpile model on the graphical Sierpinski gasket [Formula: see text]. We show that the shape is a ball in the graph metric of [Formula: see text]. Moreover, we give an exact representation of the odometer function of the divisible sandpile.
The structure of locally finite groups of finite c-dimension
Authors: Buturlakin A. A. 
Published: December 2018

The [Formula: see text]-dimension of a group is the supremum of lengths of strict nested chains of centralizers. We describe the structure of locally finite groups of finite [Formula: see text]-dimension. We also prove that the [Formula: see text]-dimension of the quotient [Formula: see text] of a locally finite group [Formula: see text] by the locally soluble radical [Formula: see text] is bounded in terms of the [Formula: see text]-dimension of [Formula: see text].
Mathieu–Zhao subspaces of vertex algebras
Authors: Yamskulna Gaywalee 
Published: December 2018

We introduce a notion of Mathieu–Zhao subspaces of vertex algebras. Among other things, we show that for a vertex algebra [Formula: see text] and its subspace [Formula: see text] that contains [Formula: see text], [Formula: see text] is a Mathieu–Zhao subspace of [Formula: see text] if and only if the quotient space [Formula: see text] is a Mathieu–Zhao subspace of a commutative associative algebra [Formula: see text]. As a result, one can study the famous Jacobian conjecture in terms of Mathieu–Zhao subspaces of vertex algebras. In addition, for a [Formula: see text]-type vertex operator algebra [Formula: see text] that satisfies the [Formula: see text]-cofiniteness condition, we classify all Mathieu–Zhao subspaces [Formula: see text] that contain [Formula: see text].
Cancer Immunity and Gene Expression Data: A Quick Tool for Immunophenotype Evaluation
Authors: Hirano Masayuki 
Published: December 2018

Abstract
The rapid advancement of next generation sequencing technology has resulted in accumulation of many datasets in cancer clinical and research laboratories, many of which do not have bioinformaticians. Xu and colleagues developed a user-friendly web-based tool to define the tumor immunophenotype among patients with cancer. By uploading user-defined datasets on the web, it can systematically track, analyze, and visualize the status of anticancer immune activity and the proportion of tumor-infiltrating immune cells. This tool can help immunologists and clinical researchers to perform quick, efficient, and comprehensive analysis of the tumor immunophenotype.
See related article by Xu et al., p. 6575
Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove
Authors: Leber Brian , Kale Justin , Andrews David W. 
Published: December 2018

Abstract

Summary:
Unleashing blocked apoptosis has emerged as an important tool in treating cancer as shown by the recent success of the BCL2 inhibitor venetoclax. However, MCL1 represents another important target as it is the predominant survival signal in many types of cancers and functions as a resistance mechanism to BCL2 inhibition. Caenepeel and colleagues and Ramsey and colleagues have developed two novel, potent, and selective MCL1 inhibitors that are effective against many hematologic malignancies, and Nangia and colleagues describe how one of these inhibitors can be successfully combined with BCL-xL and MEK inhibition to treat KRAS-mutated lung cancer.
See related article by Ramsey et al., p. 1566.
See related article by Caenepeel et al., p. 1582.
See related article by Nangia et al., p. 1598.
The Balancing Act between Cancer Immunity and Autoimmunity in Response to Immunotherapy
Authors: Young Arabella , Quandt Zoe , Bluestone Jeffrey A. 
Published: December 2018

Abstract
The explosion in novel cancer immunotherapies has resulted in extraordinary clinical successes in the treatment of multiple cancers. Checkpoint inhibitors (CPIs) that target negative regulatory molecules have become standard of care. However, with the growing use of CPIs, alone or in combination with chemotherapy, targeted therapies, or other immune modulators, a significant increase in immune-related adverse events (irAEs) has emerged. The wide-ranging and currently unpredictable spectrum of CPI-induced irAEs can lead to profound pathology and, in some cases, death. Growing evidence indicates that many irAEs are a consequence of a breakdown in self-tolerance, but the influence of genetics, the environment, and the mechanisms involved remains unclear. This review explores key questions in this emerging field, summarizing preclinical and clinical experiences with this new generation of cancer drugs, the growing understanding of the role of the immune response in mediating these toxicities, the relationship of CPI-induced autoimmunity to conventional autoimmune diseases, and insights into the mechanism of irAE development and treatment.
АНАЛІЗ АКУШЕРСЬКИХ РЕЗУЛЬТАТІВ І ТА ІІ ТРИМЕСТРІВ ВАГІТНОСТІ В ЖІНОК ІЗ РІЗНИМИ ВИДАМИ МІОМЕКТОМІЇ ТА ЗОВНІШНІМ ГЕНІТАЛЬНИМ ЕНДОМЕТРІОЗОМ В АНАМНЕЗІ
Authors: Gladchuk I. Z. , Zhelezov D. M. , Kossei T. V. 
Published: December 2018

Мета дослідження – зниження частоти акушерської патології в жінок із консервативною міомектомією та зовнішнім генітальним ендометріозом в анамнезі.
Матеріали та методи. Вивчено особливості клінічного перебігу вагітності і пологів у 100 жінок, що перенесли до вагітності консервативну міомектомію. Вагітні були розділені на дві групи залежно від методики проведеної операції і тактики ведення вагітності: І група – 50 жінок після консервативної міомектомії без видалення вогнищ ендометріозу; ІІ група – 50 жінок після консервативної міомектомії та з видаленими вогнищами ендометріозу чи ендометріомою в анамнезі. Контрольна група – 50 жінок після кесаревого розтину з міомектомією матки.
Результати дослідження та їх обговорення. Проведено аналіз частоти акушерських ускладнень по триместрах в обстежених пацієнток залежно від проведеного оперативного втручання та використання лікувально-профілактичних заходів.
Висновки. Основним ускладненням була загроза переривання вагітності: 46,0 % – у І групі та 22,0 % – в ІІ групі. Такі відмінності, на нашу думку, обумовлені використанням різних алгоритмів діагностичних і лікувально-профілактичних заходів у пацієнток після міомектомії. В II триместрі найчастішим ускладненням у вагітних основних груп був загрозливий пізній викидень, який в 2,3 раза частіше спостерігався при використанні загальноприйнятих лікувально-профілактичних заходів.
OBSTETRICIANS’ TACTICS IN THE DELIVERY BY PATIENTS WITH BREECH POSITION OF THE FOETUS AFFECTED BY THE UTERINE MYOMA
Authors: Krupnyk O. M. 
Published: December 2018

The aim of the study – improvement of pregnancy outcomes in women with pelvic presentation on the background of uterine myoma by developing optimal obstetric delivery tactics.
Materials and Methods. In order to achieve the stated goal, a prospective analysis of cases of first- and second-time delivering patients with full-term one fetus pregnancy in pelvic presentation (incomplete and complete) amid the uterine myoma – the main group (MG) – (n = 30) was conducted. Into the control group (CG) – (n = 30) were included the first- and second-time bearing women without fetal myoma with full-time pregnancy and the pelvic presentation. Statistical processing of the results was performed using the Microsoft Office Excel 2017 software.
Results and Discussion. The analysis of the presented data shows that among pregnant women with pelvic prevalence of fetuses on the background of uterine fibroids, more frequent cases are registered: clinical manifestations of the threat of interruption of pregnancy MG – 26 (86.7 %), CG – 9 (30 %) and pre-eclampsia MG – 8 (26.7 %), CG – 3 (10 %) (p < 0.05). Raising the risk of complications of pregnancy and the expected birth of the uterine myoma requires pre-planning for the most part the operational method of delivery of MG – 19 (63.3 %). Exception, in the absence of other contraindications, there may be women with single myomatous nodes in sizes up to 5 cm – 11 (36.7 %). Only the extension of the cesarean section requires only pregnant women with uterine myoma 7 (36.8 %), and most of these interventions occur during precarious surgical delivery 4 (20 %).
Conclusion. Consequently, the presented data indicate the expediency and validity of taking into account the presence of uterine myoma at BP in order to develop an optimal obstetric tactic for the delivery of such patients in order to improve their pregnancy outcomes.
Evaluation of sealing between abutment and inner connection of cone morse dental implant
Authors: Gois Filho Derivaldo Moura , Gois-Santos Vanessa Tavares de , Silva Ronaldo Santos , Marqueti Antônio Carlos , Cortes Arthur Rodriguez Gonzalez , Trento Cleverson Luciano 
Published: December 2018

Introduction: The adaptation of prostheses fixed over implants involves biomechanical aspects that are directly associated with treatment success. Objective: The aim of this in vitro study was to evaluate the presence of microgaps in the abutment/inner connection interface of cone morse dental implants. Materials and methods: Two groups of implants were analyzed. The first group (n = 16) employed single-manufacturer dental implants and abutments, whereas the second group (n = 16) combined multi-manufacturer materials. The sets were analyzed through scanning electron mi­croscopy, wherein microgaps between the implant connection and the abutment were observed. Results: Group 1 had an average microgap of 5.69 μm (SD ± 8.46 μm). Group 2 had an average microgap of 1.24 μm (SD ± 0.44 μm). A significant difference was found between the two groups (p = 0.002). Conclusion: Within the limitations of this study, results suggest that the group formed by multi-manufacturer implants and abutments (group 2) had smaller microgap values, and, therefore, a higher in vitro adaptation of components.
DESCRIPTORS | Dental Implants; Dental Abutments; Scanning Electron Microscopy.
Accuracy and Internal Fit of 3D printed Occlusal Splint, according to the printing position
Authors: Vasques Mayra Torres , Laganá Dalva Cruz 
Published: December 2018

Understanding the importance of 3D printing strategies is a key to obtain predictable, optimized and consistent dental appliances using digital technologies. This study aims to present the influence of printing orientation on the intraoral fit of full arch coverage splints. Splints were designed for two patients using the CAD software and printed in a SLA 3D printer with different orientations (0, 30, and 90 degrees), and the internal fit was checked on patients’ mouth. Differen­ces between the fit of the splints were verified, with the worst results for 90º oriented splints, although more detailed studies are recommended by the authors.
DESCRIPTORS | Three-Dimensional Printing; Accuracy; Dimensional Measurement; Occlusal Splint; Print Orientation.
Dysregulated IL-1β-GM-CSF Axis in Acute Rheumatic Fever That Is Limited by Hydroxychloroquine
Authors: Kim Man Lyang , Martin William J. , Minigo Gabriela , Keeble Joanne L. , Garnham Alexandra L. , Pacini Guido , Smyth Gordon K. , Speed Terence P. , Carapetis Jonathan , Wicks Ian P. 
Published: December 2018

Background:
Acute rheumatic fever (ARF) and rheumatic heart disease are autoimmune consequences of group A streptococcus infection and remain major causes of cardiovascular morbidity and mortality around the world. Improved treatment has been stymied by gaps in understanding key steps in the immunopathogenesis of ARF and rheumatic heart disease. This study aimed to identify (1) effector T cell cytokine(s) that might be dysregulated in the autoimmune response of patients with ARF by group A streptococcus, and (2) an immunomodulatory agent that suppresses this response and could be clinically translatable to high-risk patients with ARF.

Methods:
The immune response to group A streptococcus was analyzed in peripheral blood mononuclear cells from an Australian Aboriginal ARF cohort by a combination of multiplex cytokine array, flow cytometric analysis, and global gene expression analysis by RNA sequencing. The immunomodulatory drug hydroxychloroquine was tested for effects on this response.

Results:

We found a dysregulated interleukin-1β-granulocyte-macrophage colony-stimulating factor (GM-CSF) cytokine axis in ARF peripheral blood mononuclear cells exposed to group A streptococcus in vitro, whereby persistent interleukin-1β production is coupled to overproduction of GM-CSF and selective expansion of CXCR3
+
CCR4
−
CCR6
−
CD4 T cells. CXCR3
+
CCR4
−
CCR6
−
CD4 T cells are the major source of GM-CSF in human CD4 T cells and CXCL10, a CXCR3 ligand and potent T helper 1 chemoattractant, was elevated in sera from patients with ARF. GM-CSF has recently emerged as a key T cell-derived effector cytokine in numerous autoimmune diseases, including myocarditis, and the production of CXCL10 may explain selective trafficking of these cells to the heart. We provide evidence that interleukin-1β amplifies the expansion of GM-CSF-expressing CD4 T cells, which is effectively suppressed by hydroxychloroquine. RNA sequencing showed shifts in gene expression profiles and differentially expressed genes in peripheral blood mononuclear cells derived from patients at different clinical stages of ARF.

Conclusions:
Given the safety profile of hydroxychloroquine and its clinical pedigree in treating autoimmune diseases such as rheumatoid arthritis, where GM-CSF plays a pivotal role, we propose that hydroxychloroquine could be repurposed to reduce the risk of rheumatic heart disease after ARF.