bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fate decision of satellite cell differentiation and self-renewal by miR-31-IL34 axis
Authors: Su Yang , Yu Yingying , Liu Chuncheng , Zhang Yuying , Liu Chang , Ge Mengxu , Li Lei , Lan Miaomiao , Wang Tongtong , Li Min , Liu Fan , Xiong Lei , Wang Kun , He Ting , Shi Jianyun , Song Yongli , Zhao Yaofeng , Li Ning , Yu Zhengquan , Meng Qingyong 
Published: July 2019

Abstract
Quiescent satellite cells (SCs) that are activated to produce numerous myoblasts underpin the complete healing of damaged skeletal muscle. How cell-autonomous regulatory mechanisms modulate the balance among cells committed to differentiation and those committed to self-renewal to maintain the stem cell pool remains poorly explored. Here, we show that miR-31 inactivation compromises muscle regeneration in adult mice by impairing the expansion of myoblasts. miR-31 is pivotal for SC proliferation, and its deletion promotes asymmetric cell fate segregation of proliferating cells, resulting in enhanced myogenic commitment and re-entry into quiescence. Further analysis revealed that miR-31 posttranscriptionally suppresses interleukin 34 (IL34) mRNA, the protein product of which activates JAK–STAT3 signaling required for myogenic progression. IL34 inhibition rescues the regenerative deficiency of miR-31 knockout mice. Our results provide evidence that targeting miR-31 or IL34 activities in SCs could be used to counteract the functional exhaustion of SCs in pathological conditions.
Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis
Authors: McMahon Kerrie-Ann , Wu Yeping , Gambin Yann , Sierecki Emma , Tillu Vikas A. , Hall Thomas , Martel Nick , Okano Satomi , Moradi Shayli Varasteh , Ruelcke Jayde E. , Ferguson Charles , Yap Alpha S. , Alexandrov Kirill , Hill Michelle M. , Parton Robert G. 
Published: July 2019

AbstractCaveolae are specialized domains of the plasma membrane. Formation of these invaginations is dependent on the expression of Caveolin-1 or -3 and proteins of the cavin family. In response to stress, caveolae disassemble and cavins are released from caveolae, allowing cavins to potentially interact with intracellular targets. Here, we describe the intracellular (non-plasma membrane) cavin interactome using biotin affinity proteomics and mass spectrometry. We validate 47 potential cavin-interactor proteins using a cell-free expression system and protein-protein binding assays. These data, together with pathway analyses, reveal unknown roles for cavin proteins in metabolism and stress signaling. We validated the interaction between one candidate interactor protein, protein phosphatase 1 alpha (PP1α), and Cavin-1 and -3 and show that UV treatment causes release of Cavin3 from caveolae allowing interaction with, and inhibition of, PP1α. This interaction increases H2AX phosphorylation to stimulate apoptosis, identifying a pro-apoptotic signaling pathway from surface caveolae to the nucleus.
Arbitrarily routed mode-division multiplexed photonic circuits for dense integration
Authors: Liu Yingjie , Xu Ke , Wang Shuai , Shen Weihong , Xie Hucheng , Wang Yujie , Xiao Shumin , Yao Yong , Du Jiangbing , He Zuyuan , Song Qinghai 
Published: July 2019

AbstractOn-chip integrated mode-division multiplexing (MDM) is an emerging technique for large-capacity data communications. In the past few years, while several configurations have been developed to realize on-chip MDM circuits, their practical applications are significantly hindered by the large footprint and inter-mode cross talk. Most importantly, the high-speed MDM signal transmission in an arbitrarily routed circuit is still absent. Herein, we demonstrate the MDM circuits based on digitized meta-structures which have extremely compact footprints. 112 Gbit/s signals encoded on each mode are arbitrarily routed through the circuits consisting of many sharp bends and compact crossings with a bit error rate under forward error correction limit. This will significantly improve the integration density and benefit various on-chip multimode optical systems.
Genomic epidemiology of syphilis reveals independent emergence of macrolide resistance across multiple circulating lineages
Authors: Beale Mathew A. , Marks Michael , Sahi Sharon K. , Tantalo Lauren C. , Nori Achyuta V. , French Patrick , Lukehart Sheila A. , Marra Christina M. , Thomson Nicholas R. 
Published: July 2019

AbstractSyphilis is a sexually transmitted infection caused by Treponema pallidum subspecies pallidum and may lead to severe complications. Recent years have seen striking increases in syphilis in many countries. Previous analyses have suggested one lineage of syphilis, SS14, may have expanded recently, indicating emergence of a single pandemic azithromycin-resistant cluster. Here we use direct sequencing of T. pallidum combined with phylogenomic analyses to show that both SS14- and Nichols-lineages are simultaneously circulating in clinically relevant populations in multiple countries. We correlate the appearance of genotypic macrolide resistance with multiple independently evolved SS14 sub-lineages and show that genotypically resistant and sensitive sub-lineages are spreading contemporaneously. These findings inform our understanding of the current syphilis epidemic by demonstrating how macrolide resistance evolves in Treponema subspecies and provide a warning on broader issues of antimicrobial resistance.
Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity
Authors: Wang Hongdong , Shen Lei , Sun Xitai , Liu Fangcen , Feng Wenhuan , Jiang Chunping , Chu Xuehui , Ye Xiao , Jiang Can , Wang Yan , Zhang Pengzi , Zang Mengwei , Zhu Dalong , Bi Yan 
Published: July 2019

AbstractPathogenic factors driving obesity to type 2 diabetes (T2D) are not fully understood. Group 1 innate lymphoid cells (ILC1s) are effectors of innate immunity and enriched in inflamed tissues. Here we show that the number of adipose ILC1s increases in obese T2D patients and correlates with glycemic parameters and with the number of ILC1s in the blood; circulating ILC1 numbers decrease as a result of metabolic improvements after bariatric surgery. In vitro co-culture experiments show that human adipose ILC1s promote adipose fibrogenesis and CD11c+ macrophage activation. Reconstruction of the adipose ILC1 population in Prkdc−/−IL2rg−/− mice by adoptive transfer drives adipose fibrogenesis through activation of TGFβ1 signaling; however, transfer of Ifng−/− ILC1s has no effect on adipose fibrogenesis. Furthermore, inhibiting adipose accumulation of ILC1s using IL-12 neutralizing antibodies attenuates adipose tissue fibrosis and improves glycemic tolerance. Our data present insights into the mechanisms of local immune disturbances in obesity-related T2D.
Microbial metagenomes and metatranscriptomes during a coastal phytoplankton bloom
Authors: Nowinski Brent , Smith Christa B. , Thomas Courtney M. , Esson Kaitlin , Marin Roman , Preston Christina M. , Birch James M. , Scholin Christopher A. , Huntemann Marcel , Clum Alicia , Foster Brian , Foster Bryce , Roux Simon , Palaniappan Krishnaveni , Varghese Neha , Mukherjee Supratim , Reddy T. B. K. , Daum Chris , Copeland Alex , Chen I.-Min A. , Ivanova Natalia N. , Kyrpides Nikos C. , Glavina del Rio Tijana , Whitman William B. , Kiene Ronald P. , Eloe-Fadrosh Emiley A. , Moran Mary Ann 
Published: July 2019

AbstractMetagenomic and metatranscriptomic time-series data covering a 52-day period in the fall of 2016 provide an inventory of bacterial and archaeal community genes, transcripts, and taxonomy during an intense dinoflagellate bloom in Monterey Bay, CA, USA. The dataset comprises 84 metagenomes (0.8 terabases), 82 metatranscriptomes (1.1 terabases), and 88 16S rRNA amplicon libraries from samples collected on 41 dates. The dataset also includes 88 18S rRNA amplicon libraries, characterizing the taxonomy of the eukaryotic community during the bloom. Accompanying the sequence data are chemical and biological measurements associated with each sample. These datasets will facilitate studies of the structure and function of marine bacterial communities during episodic phytoplankton blooms.
A quantitative, high-throughput method identifies protein–glycan interactions via mass spectrometry
Authors: Kitov Pavel I. , Kitova Elena N. , Han Ling , Li Zhixiong , Jung Jaesoo , Rodrigues Emily , Hunter Carmanah D. , Cairo Christopher W. , Macauley Matthew S. , Klassen John S. 
Published: July 2019

AbstractGlycan binding by glycan-binding proteins and processing by carbohydrate-active enzymes is implicated in physiological and pathophysiological processes. Comprehensive mapping of glycan interactions is essential to understanding of glycan-mediated biology and can guide the development of new diagnostics and therapeutics. Here, we introduce the competitive universal proxy receptor assay (CUPRA), which combines electrospray ionization mass spectrometry, competitive binding and heterobifunctional glycan-based ligands to give a quantitative high-throughput method for screening glycan libraries against glycan-binding and glycan-processing proteins. Application of the assay to human (siglec-2), plant (Sambucus nigra and Maackia amurensis lectins) and bacterial (cholera toxin, and family 51 carbohydrate binding module) proteins allowed for the identification of ligands with affinities (Kd) ≤ 1 mM. The assay is unprecedentedly versatile and can be applied to natural libraries and, when implemented in a time-resolved manner, provides a quantitative measure of the activities and substrate specificity of carbohydrate-active enzymes.
The Accuracy of Respiratory Calibration Methods for Estimating Lung Volume During Speech Breathing: A Comparison of Four Methods Across Three Adult Cohorts
Authors: McKenna Victoria S. , Huber Jessica E. 
Published: July 2019

Purpose
This study evaluated the accuracy of respiratory calibration methods for estimating lung volume during speech breathing.

Method
Respiratory kinematic data were acquired via inductance plethysmography in 32 young adults, 22 older adults, and 13 older adults with Parkinson's disease (PD). Raw rib cage (RC) and abdomen (AB) signals (V) were calibrated to liters using 4 correction methods: (a) isovolume maneuvers, (b) a constant 2:1 RC-to-AB ratio, (c) least squares method with RC correction only (LsqRC), and (d) least squares method with both RC and AB corrections (LsqRC/AB). Mean percent error, the absolute difference between estimated and actual lung volumes then normalized to each speaker's vital capacity, was calculated for each method.

Results
For young adults, the LsqRC/AB method significantly reduced mean percent error compared to all other methods. Although LsqRC/AB also resulted in smaller errors for older adults and adults with PD, LsqRC/AB and LsqRC were not significantly different from one another in these groups.

Conclusion
The LsqRC/AB method reduces errors across all cohorts, but older adults and adults with PD also have reduced errors when using LsqRC. Further research should investigate both least squares methods across larger age and disease severity ranges.
STEPAR: an automatic code to infer stellar atmospheric parameters
Authors: Tabernero H. M. , Marfil E. , Montes D. , González Hernández J. I. 
Published: July 2019

Context. STEPAR is an automatic code written in Python 3.X designed to compute the stellar atmospheric parameters Teff, log g, [Fe/H], and ξ of FGK-type stars by means of the equivalent width (EW) method. This code has already been extensively tested in different spectroscopic studies of FGK-type stars with several spectrographs and against thousands of Gaia-ESO Survey UVES U580 spectra of late-type, low-mass stars as one of its 13 pipelines.
Aims. We describe the code that we tested against a library of well characterised Gaia benchmark stars. We also release the code to the community and provide the link for download.
Methods. We carried out the required EW determination of Fe I and Fe II spectral lines using the automatic tool TAME. STEPAR implements a grid of MARCS model atmospheres and the MOOG radiative transfer code to compute stellar atmospheric parameters by means of a Downhill Simplex minimisation algorithm.
Results. We show the results of the benchmark star test and also discuss the limitations of the EW method, and hence the code. In addition, we find a small internal scatter for the benchmark stars of 9 ± 32 K in Teff, 0.00 ± 0.07 dex in log g, and 0.00 ± 0.03 dex in [Fe/H]. Finally, we advise against using STEPAR on double-lined spectroscopic binaries or spectra with R <  30 000, S/N <  20, or v sin i >  15 km s−1, and on stars later than K4 or earlier than F6.
Big Imaging Data: Klinische Bildanalyse mit Radiomics und Deep Learning
Authors: Demircioglu Aydin , Koitka Sven , Nensa Felix 
Published: July 2019

ZusammenfassungRadiomics ist eine Methode der medizinischen Bildanalyse, bei der quantitative Merkmale aus Bilddaten extrahiert und mittels Machine Learning zu prädiktiven Modellen weiterverarbeitet werden. Ziel dieser Arbeit ist es, die technischen Grundlagen von Radiomics und mögliche klinische Anwendungen unter besonderer Berücksichtigung nuklearmedizinischer Daten zu erläutern. Dabei wird zunächst die klassische Radiomics-Methode besprochen, welche auf einer exakten Segmentierung der zu analysierenden Pathologie beruht und bei der die Features manuell definiert werden müssen. Anschließend wird auf das noch wenig verbreitete, allerdings vielversprechende Deep Learning basierte Radiomics eingegangen, dessen Vorteile darin liegen, dass ausschließlich datengetrieben gearbeitet wird und daher weder exakte Segmentierungen noch manuelle Definitionen der Features benötigt werden. Abschließend werden einige Anwendungen von Radiomics besprochen, die zukünftig im klinischen Alltag eine Rolle spielen könnten.
Künstliche Intelligenz zur Detektion, Quantifizierung und Charakterisierung des metastasierten Prostatakarzinoms in der PSMA-PET/CT – Wo stehen wir?
Authors: Afshar-Oromieh Ali , Rominger Axel , Shi Kuangyu 
Published: July 2019

ZusammenfassungDas Prostatakarzinom (PCa) ist der weltweit häufigste maligne Tumor bei Männern. Seit ihrer klinischen Einführung in 2011 hat sich sowohl die PET/CT als auch die Radioligandentherapie mit PSMA-Liganden zur Diagnostik bzw. Therapie des PCa weltweit rasch ausgebreitet. Obwohl die PSMA-PET/CT als ein signifikanter Durchbruch in der Diagnostik des PCa gilt, stellt die Evaluation und Kontrolle aller Tumorherde inklusive ihrer Volumina und Charakteristika bei fortgeschrittener, multimetastatischer PCa nach wie vor eine große Herausforderung dar. Diese gilt es zu bewältigen, um beispielsweise eine Optimierung der Endoradiotherapie mit PSMA-Liganden zu erreichen. In diesem Kontext könnte die künstliche Intelligenz, die in den letzten Jahren signifikante Fortschritte erzielt hat, in der nahen Zukunft eine wichtige Rolle spielen. Die Artificial Intelligence (AI) hat bereits demonstriert, dass sie den menschlichen Fähigkeiten zur Datenverarbeitung überlegen sein kann und bietet damit großes Potential zur Verbesserung der Detektion, Quantifizierung und Charakterisierung von PCa-Herden in der PSMA-PET/CT. Die hier vorliegende Schrift befasst sich mit den aktuellen Entwicklungen der künstlichen Intelligenz für den Einsatz in der PSMA-PET/CT und den sich daraus bietenden Möglichkeiten.
Combined versus single use 20 G fine-needle biopsy and 25 G fine-needle aspiration for endoscopic ultrasound-guided tissue sampling of solid gastrointestinal lesions
Authors: van Riet Priscilla A. , Giorgio Arcidiacono Paolo , Petrone Mariachiara , Quoc Nguyen Nam , Kitano Masayuki , Chang Kenneth , Larghi Alberto , Iglesias-Garcia Julio , Giovannini Marc , van der Merwe Schalk , Santo Erwin , Baldaque-Silva Francisco , Bucobo Juan Carlos , Bruno Marco J. , Aslanian Harry R. , Cahen Djuna L. , Farrell James 
Published: July 2019

Abstract
Background Instead of choosing one endoscopic ultrasound (EUS) needle over the other, some advocate the use of fine-needle aspiration (FNA) and fine-needle biopsy (FNB) consecutively. We explored the yield of combined use of 20 G FNB and 25 G FNA needles in patients with a suspicious solid gastrointestinal lesion.
Methods Patients from the ASPRO study who were sampled with both needles during the same procedure were included. The incremental yield of dual sampling compared with the yield of single needle use on the diagnostic accuracy for malignancy was assessed for both dual sampling approaches – FNA followed by FNB, and vice versa.
Results 73 patients were included. There were 39 (53 %) pancreatic lesions, 18 (25 %) submucosal masses, and 16 (22 %) lymph nodes. FNA was used first in 24 patients (33 %) and FNB was used first in 49 (67 %). Generally, FNB was performed after FNA to collect tissue for ancillary testing (75 %), whereas FNA was used after FNB to allow for on-site pathological assessment (76 %). Diagnostic accuracy for malignancy of single needle use increased from 78 % to 92 % with dual sampling (P = 0.002). FNA followed by FNB improved the diagnostic accuracy for malignancy (P = 0.03), whereas FNB followed by FNA did not (P = 0.13).
Conclusion Dual sampling only improved diagnostic accuracy when 25 G FNA was followed by 20 G FNB and not vice versa. As the diagnostic benefit of the 20 G FNB over the 25 G FNA needle has recently been proven, sampling with the FNB needle seems a logical first choice.
Novel Approach to Repairing a Traumatic Aortic Arch Pseudoaneurysm Following a Fall
Authors: Hussain Azhar , Youssefi Pouya , Soppa Gopal , Jahangiri Marjan 
Published: July 2019

AbstractTraumatic pseudoaneurysms of the aortic arch are often treated with surgical repair regardless of the lesion size or age. The authors report a simple, less invasive surgical repair in a patient who sustained blunt aortic injury following a fall.
18-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography to Guide Aortic Arch Replacement in Relapsing Polychondritis
Authors: Pfister Raymond , Messe Maria , Niclauss Lars , Kirsch Matthias , Haller Claude , Delay Dominique 
Published: July 2019

AbstractRelapsing polychondritis (RP) is a rare progressive autoimmune disease. The cardiovascular system is rarely involved. The authors report the case of a young woman with RP aortic arch aneurysm and symptomatic cerebral vessels stenosis. A positron emission tomography-computed tomography (PET–CT) indicated areas with activity and guided the surgery. Aortic arch with proximal vessels was successfully replaced. The PET–CT may be useful to assess the risks and determine healthy zones for potential anastomotic sites.
Acute Type A Aortic Dissection Surgery Performed by Aortic Specialists Improves 2-Year Outcomes
Authors: Bin Mahmood Syed Usman , Mori Makoto , Geirsson Arnar , Elefteriades John A. , Mangi Abeel A. 
Published: July 2019

Objective In patients presenting with acute Type A aortic dissections (ATADs), the authors sought to evaluate whether emergent aortic operations performed by cardiac surgeons with different level of aortic surgery experience can impact perioperative outcomes and survival.
Methods A single-center review of 102 patients who underwent aortic surgeries for ATAD was conducted. The cohort was divided into those operated on by aortic specialists (AS:3 surgeons) and non-AS (5 surgeons). Multivariable logistic regression and Cox proportional hazard models were fitted to evaluate associations between the surgeon experience, perioperative outcomes, and survival, respectively.
Results Of 102 patients, 60 were operated on by AS and 42 were operated on by non-AS. Overall 30-day mortality was 11 (10.8%) with 4 (6.6%) perioperative deaths in the AS group and 7 (16.6%) among the non-AS group (p = 0.2). AS performed a significantly higher number of root replacement procedures (41.6% vs. 23.8%, respectively, p = 0.049) and employed more frequent adjunct cerebral perfusion during circulatory arrest (p = 0.003). Survival analysis indicated AS status was an independent predictor of improved 2-year survival (hazard ratio: 0.37, 95% confidence interval: 0.15–0.92, p = 0.03).
Conclusion Operation by AS for ATAD was associated with reduced adjusted risk of 2-year mortality. This adds support for establishing thoracic aortic emergency call teams staffed by AS.
Validation of Duplex Ultrasound Graft Surveillance in the Immediate Postoperative Period
Authors: Argyriou Christos , Georgiadis George S. 
Published: July 2019

AbstractA femoral crossover polytetrafluoroethylene graft was performed in a patient immediately, after a failed iliac endograft limb recanalization, performed 2 years after endovascular aortic aneurysm repair. Although graft patency was confirmed clinically by palpation of groin pulses as well as noninvasively by segmental pressure measurements and Doppler examination, in the immediate postoperative period, duplex ultrasound failed to show any blood flow inside the graft lumen until the fourth postoperative day. Subcutaneous air and air tapped within the wall structure of the graft are possible explanation for the failure to show flow.
Optic Neuropathy, Secondary to Ethmoiditis, and Onodi Cell Inflammation during Childhood: A Case Report and Review of the Literature
Authors: Mazzurco Marina , Pavone Piero , Di Luca Milena , Smilari Pierluigi , Pustorino Elena , Fiumara Agata , Di Mauro Paola , Greco Filippo , Cocuzza Salvatore 
Published: July 2019

AbstractOptic neuropathy consists of several etiological events. The primary etiologies of its acute form include optic neuritis, ischemic optic neuropathy, inflammatory (nondemyelinating) disorders, and trauma. Its subacute and chronic forms are most often linked to compressive, toxic, nutritional, or hereditary-genetic causes. Visual loss, dyschromatopsia, and visual field defects are the presenting symptoms. The Onodi cell (sphenoethmoidal air cell) is an anatomic variant located laterally and superior to the sphenoid sinus; it is closely related to the optic nerve. Onodi cell disorders are rare and may be unnoticed in differential diagnoses of patients with ocular and neurological manifestations. Here, we present the case of a 12-year-old boy with headache and acute loss of sight characterized by hemianopsia in the left eye and retrobulbar optic neuropathy caused by left sphenoethmoidal sinusitis with the presence of Onodi cell inflammation. The diagnosis was confirmed by multilayered paranasal computed tomography and cerebral magnetic resonance imaging. Therapeutic treatment resulted in gradual improvement: at the 2-week follow-up, the patient no longer had headaches and his visual acuity returned to normal. Inflammation of Onodi cells should be considered in children with headache and abnormal vision.
How should we think about a trans-cultural hermeneutics?
Authors: Achella Stefania 
Published: July 2019

Abstract
One of the first modern discussions on untranslatability in philosophy, in particular in relation to Asian philosophy, is the controversy between Georg Wilhelm Hegel and Wilhelm von Humboldt. This controversy began in 1823, with the publication of August Schlegel’s translation from Sanskrit into Latin of the Bhagavad-Gītā, one of the most important poems of Indian culture. This translation generated a strong debate among German intellectuals between 1770 and 1830, not only about the difficulty of philosophical translation, but also about how to develop a trans-cultural hermeneutics. The paper reconstructs the outlines of this debate, by bringing out its inner complexity and showing how many of those problems still remain in the current intercultural debate.