bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endocrine regulation of lung disease and inflammation
Authors: Fuentes Nathalie , Silveyra Patricia 
Published: December 2018

Sex-based disparities have been identified in respiratory physiology, and in many chronic lung diseases including asthma, chronic obstructive pulmonary disease, and cystic fibrosis. The observed sex differences in lung disease prevalence and incidence have been linked to changes in circulating levels of sex hormones that start after puberty and that have been shown to affect physiological and immunological functions. While the exact roles of male and female sex hormones in these processes have not been fully elucidated, it is now evident that these can target many lung cell types and affect several functions of the respiratory system. In this mini-review, we have summarized seminal studies aimed to understand the effects of the most relevant male and female sex hormones (estrogens, progesterone, and androgens) and their receptors on lung function. Moreover, we have reviewed the known influences of sex hormones and of the hypothalamic–pituitary–gonadal axis in lung disease and immunity. Understanding the roles of sex hormones in the regulation of lung function and inflammation is the first step for the potential development of more effective therapeutic options to prevent and treat lung disease in men and women. Impact statement Sex-differences in the incidence and severity of inflammatory lung diseases have been recognized for years. Women of reproductive age are more likely to suffer from chronic lung disease, with higher mortality rates than men. Physiological changes in hormone levels such as those occurring during the menstrual cycle, pregnancy, and menopause have been associated with lung function changes and asthma symptoms. Despite this, the roles of sex hormones in the mechanisms associated with lung diseases have not been fully elucidated. This review summarizes basic and clinical studies of sex hormones as potential modulators of lung function and inflammation. The information obtained from sex-specific research on lung physiology and pathology will potentially help in the development of sex-specific therapeutics for inflammatory lung disease that may account for the hormonal status of the patient.
A survey of vascular specialists’ practice patterns of inferior vena cava filter placement and retrieval
Authors: Brahmandam Anand , Skrip Laura , Sumpio Bauer , Indes Jeffrey , Dardik Alan , Sarac Timur , Rectenwald John , Chaar Cassius Iyad Ochoa 
Published: December 2018

Objectives The placement of inferior vena cava filters (IVCF) continues to rise. Vascular specialists adopt different practices based on local expertise. This study was performed to assess the attitudes of vascular specialists towards the placement and retrieval of IVCF. Methods An online survey of 28 questions related to practice patterns regarding IVCF was administered to 1429 vascular specialists. Vascular specialists were categorized as low volume if they place less than three IVCF per month and high volume if they place at least three IVCF per month. The responses of high volume and low volume were compared using two-sample t-tests and Chi-square tests. Results A total of 259 vascular specialists completed the survey (18% response rate). There were 191 vascular surgeons (74%) and 68 interventional radiologists (26%). The majority of responders were in academic practice (67%) and worked in tertiary care centers (73%). The retrievable IVCF of choice was Celect (27%) followed by Denali (20%). Forty-two percent used a temporary IVCF and left it in situ instead of using a permanent IVCF. Eighty-two percent preferred placing the tip of the IVCF at or just below the lowest renal vein. Thirty-one percent obtained a venous duplex of the lower extremities prior to retrieval while 24% did not do any imaging. There were 132 (51%) low volume vascular specialists and 127 (49%) high volume vascular specialists. Compared to low volume vascular specialists, significantly more high volume vascular specialists reported procedural times of less than 30 min for IVCF retrieval (57% vs. 42%, P = 0.026). There was a trend for high volume to have fewer unsuccessful attempts at IVCF retrieval but that did not reach statistical significance ( P = .061). High volume were more likely to have attempted multiple times to retrieve an IVCF (66% vs. 33%, P < .001), and to have used bronchoscopy forceps (32% vs. 14%, P = .001) or a laser sheath (14% vs. 2%, P < .001) for IVCF retrieval. In general, vascular specialists were not comfortable using bronchoscopy forceps (65%) or a laser sheath (82%) for IVCF retrieval. Conclusions This study underscores significant variability in vascular specialists practice patterns regarding IVCF. More studies and societal guidelines are needed to define best practices.
Quantitative assessment of elbow flexion by handheld dynamometry in brachial plexus palsy
Authors: Marei Abdelhakim , Doi Kazuteru , Hattori Yasunori , Sakamot Soutetsu 
Published: December 2018

The purpose of this study was to assess the relative and absolute reliability of a handheld dynamometer when used for examining elbow flexion power in patients with brachial plexus palsy. The assessment of the intra-rater and inter-rater reliability coefficients for the handheld dynamometer was done using the stationary Kin-Com® dynamometer as the reference standard. We determined the measurement errors and checked the systematic biases of the handheld dynamometer. The inter-rater and intra-rater reliabilities of the handheld dynamometer had a very high intraclass correlation coefficient. The values of handheld dynamometer readings had a high correlation to Kin-Com® readings. The Medical Research Council grading was a comparatively inaccurate method for quantitative assessment of motor power. We conclude that a handheld dynamometer measurement is more precise and reliable than the Medical Research Council grading for measuring recovery of elbow flexion in patients with brachial plexus palsy. Level of evidence: III
Improvement of low-density lipoprotein cholesterol target achievement rates through cardiac rehabilitation for patients after ST elevation myocardial infarction or non-ST elevation myocardial infarction in Germany: Results of the PATIENT CARE registry
Authors: Schwaab Bernhard , Zeymer Uwe , Jannowitz Christina , Pittrow David , Gitt Anselm 
Published: December 2018

Aims The PATIENT CARE registry aimed to document clinical characteristics of patients during cardiac rehabilitation after myocardial infarction, including the current pharmacological treatment, risk factor modification and achievement of treatment targets for low-density lipoprotein cholesterol (LDL-C). Methods Multicentre, prospective non-interventional study at 20 cardiac rehabilitation in-patient centres across Germany. Results A total of 1408 patients post myocardial infarction were analysed. Patients’ mean age was 62 ± 11 years and 27.0% were women. ST elevation myocardial infarction ( n = 657; 48.7%), and non-ST elevation myocardial infarction ( n = 617; 45.8%) were equally balanced causes for hospitalization, while previous coronary artery bypass grafting was reported in n = 134 patients (9.9%). On average, cardiac rehabilitation began 19 ± 10 days after the index event and lasted for 22 ± 4 days. At discharge, 96.7% of patients received statins, 13.0% another lipid-lowering medication in addition to a statin, 98.5% antithrombotic drugs and 22.3% antidiabetic medication. The rate of patients with LDL-C on target according to the European Society of Cardiology/European Atherosclerosis Society dyslipidaemia guidelines 2011 (<70 mg/dl (1.8 mmol/l) or at least 50% reduction of baseline value) was increased from 21.4% at admission to cardiac rehabilitation to 41.9% at discharge after cardiac rehabilitation. Most patients (95.2%) completed the cardiac rehabilitation and 88% returned to their former work at full time. Conclusion During cardiac rehabilitation, the modifiable cardiovascular risk factors, in particular the LDL-C, were substantially improved in patients after myocardial infarction. The great majority were able to return to work. However, less than 50% reached the LDL-C guideline targets during short-term cardiac rehabilitation.
Chronic Unpredictable Stress Reduces Immunostaining for Connexins 43 and 30 and Myelin Basic Protein in the Rat Prelimbic and Orbitofrontal Cortices
Authors: Miguel-Hidalgo José Javier , Moulana Mohadetheh , Deloach Preston Hardin , Rajkowska Grazyna 
Published: December 2018

Background Astrocytes and oligodendrocytes are pathologically altered in dorsolateral prefrontal and orbitofrontal cortices in major depressive disorder. In rat models of stress (major depressive disorder risk factor) astrocyte gap junction protein connexin 43 (Cx43) is reduced in the prelimbic cortex. Astrocyte connexins are recognized to strongly influence myelin maintenance in the central nervous system. However, it is unknown whether stress-related changes in Cx43 and the other major astrocyte connexin, Cx30, occur in the orbitofrontal cortex, or whether connexin changes are concurrent with disturbances in myelination. Methods Frozen sections containing prelimbic cortex and orbitofrontal cortex of rats subjected to 35 days of chronic unpredictable stress and controls (n = 6/group) were immunolabeled for Cx43, Cx30, and myelin basic protein. Density of Cx43 or Cx30 immunoreactive puncta and area fraction of myelin basic protein immunoreactivity were measured in prelimbic cortex and orbitofrontal cortex and results analyzed with t test or Pearson correlations. Results Density of Cx43- and Cx30-positive puncta in both prelimbic cortex and orbitofrontal cortex was lower in chronic unpredictable stress-treated than in control rats. In both regions, the area fraction of myelin basic protein immunoreactivity was also lower in chronic unpredictable stress animals. Myelin basic protein area fraction was positively correlated with the density of Cx43-positive puncta in orbitofrontal cortex, and with Cx30 puncta in prelimbic cortex. Conclusion Low Cx43 and Cx30 after chronic unpredictable stress in rat prelimbic cortex and orbitofrontal cortex suggests that reduced astrocytic gap junction density may generalize to the entire prefrontal cortex. Concurrent reduction of Cx43-, Cx30-, and myelin basic protein-immunolabeled structures is consistent with a mechanism linking changes in astrocyte gap junction proteins and disturbed myelin morphology in depression.
Investigating the influence of online interpersonal interaction on purchase intention based on stimulus-organism-reaction model
Authors: Liu Yaqin , Luo Xinxing , Cao Yi 
Published: December 2018

Abstract
Based on the stimulus-organism-reaction model, we study the direct effects of the three interpersonal attraction factors (perceived similarity, perceived familiarity, and perceived expertise) on purchase intention in the social commerce era, as well as the mediating roles of the normative and informational influence of reference groups in the above relationship. We apply structural equation model to the study samples consisting of 490 WeChat users. The results of empirical research indicate that the three interpersonal attraction factors have positive effects on purchase intention. Both the normative and informational influence fully mediate the effect of perceived familiarity on purchase intention, but only partially mediate the effects of perceived similarity and perceived expertise on purchase intention. The findings provided practitioners with insights into enhancing users’ intention to purchase in social commerce.
The role of environmental exposure to non‐cigarette smoke in lung disease
Authors: KC Rajendra , Shukla Shakti D. , Gautam Sanjay S. , Hansbro Philip M. , O’Toole Ronan F. 
Published: December 2018

AbstractChronic exposure to household indoor smoke and outdoor air pollution is a major contributor to global morbidity and mortality. The majority of these deaths occur in low and middle‐income countries. Children, women, the elderly and people with underlying chronic conditions are most affected. In addition to reduced lung function, children exposed to biomass smoke have an increased risk of developing lower respiratory tract infections and asthma‐related symptoms. In adults, chronic exposure to biomass smoke, ambient air pollution, and opportunistic exposure to fumes and dust are associated with an increased risk of developing chronic bronchitis, chronic obstructive pulmonary disease (COPD), lung cancer and respiratory infections, including tuberculosis. Here, we review the evidence of prevalence of COPD in people exposed to non‐cigarette smoke. We highlight mechanisms that are likely involved in biomass‐smoke exposure‐related COPD and other lung diseases. Finally, we summarize the potential preventive and therapeutic strategies for management of COPD induced by non‐cigarette smoke exposure.
Composting Feminisms and Environmental Humanities
Authors: Hamilton Jennifer Mae , Neimanis Astrida 
Published: December 2018

AbstractComposting is a material labor whereby old scraps are transformed—through practices of care and attention—into nutrient-rich new soil. In this provocation, we develop “composting” as a material metaphor to tell a particular story about the environmental humanities. Building on Donna Haraway’s work, we insist “it matters what compostables make compost.” Our argument is twofold. First, we contend that certain feminist concepts and commitments are foundational to the environmental humanities’ contemporary emergence. Second, we advocate for more inclusive feminist composting for the future of our field.We begin with a critical cartography of some of the field’s origin stories. While we discover that feminism is named or not named in several different ways, what most interests us here is a particular trend we observe, whereby key feminist scholars or concepts may be mentioned, but their feminist investments are not incorporated as such. Following this cartography, we dig into the stakes of these missed opportunities. A failure to acknowledge the feminist context that grows some of our field’s foundational concepts neutralizes their feminist politics and undermines the potential for environmental humanities to build alternative worlds. To conclude, we propose feminist composting as a methodology to be taken up further. We call for an inclusive feminist composting that insists on feminism’s imbrication with social justice projects of all kinds, at the same time as we insist that future composting be done with care. Sometimes paying attention to the feminist scraps that feed the pile means responding to feminism’s own potential assimilations and disavowals, particularly in relation to decolonization.Like both the energy-saving domestic practice and the earlier social justice struggles that inspire it, composting feminism and environmental humanities involves messy and undervalued work. We maintain, however, that it is a mode of scholarship necessary for growing different kinds of worlds.
Factors associated with the utilization of long-acting reversible contraceptives among family planning clients at the Pameungpeuk Rural Hospital, Indonesia
Authors: Harzif Achmad Kemal , Mariana Ana , Malik Devi Marischa , Silvia Melisa , Lovita Bara Tracy 
Published: December 2018

Background: Uncontrolled population development can prompt an assortment of populace issues and can be one of the reasons for increasing maternal death rates. The utilization of contraceptives in Indonesia was progressively dominated by injectable contraceptives and pill contraceptives in 2015 (52.21% and 24.36%, respectively). However, the rate of termination of the use of short-acting contraceptives by family planning clients was higher than other methods, therefore the use of short-acting contraceptive is not effective enough for use. In anticipating the decreased use of short-acting contraceptives while also seeking to control population growth, the National Family Planning Program in Indonesia is encouraging the use of long-acting reversible contraceptives (LARCs). Pameungpeuk is a region which has the second largest population, with the highest total fertility rate in South-West Java. The proportion of active users of LARCs in Pameungpeuk is also very low (10.66%). This study therefore aimed to analyze factors associated with the utilization of LARCs among family planning clients at the Pameungpeuk Rural Hospital.Methods: This study used a cross-sectional design with systematic random sampling. The sample group in this study was 84 family planning clients. We performed statistical analyses using a chi-square test.Results: We found significant associations between the age of women (p=0.024), the cost of contraception (p=0.022), knowledge (p=0.042), beliefs (p=0.002), skill of health workers (p=0.008) and support from health workers (p=0.014). However, education (p=0.212), family income (p=0.087), attitude (p=0.593), exposure to information on LARCs (p=0.378), support from partners (p=0.094), support from friends (p=0.414) and the support of community leaders (p=0.367) had no significant association with the utilization of LARCs.Conclusions: These findings highlight a critical need for improved education among family planning clients at the Pameungpeuk rural hospital regarding the use of LARCs for both medical and elective reasons.
Developing fit-for-purpose self-report instruments for assessing consumer responses to tobacco and nicotine products: the ABOUT™ Toolbox initiative
Authors: Chrea Christelle , Acquadro Catherine , Afolalu Esther F. , Spies Erica , Salzberger Thomas , Abetz-Webb Linda , Cano Stefan , Arnould Benoit , Mainy Nelly , Rose Jed , Weitkunat Rolf 
Published: December 2018

Background. Determining the public health impact of tobacco harm reduction strategies requires the assessment of consumer perception and behavior associated with tobacco and nicotine products (TNPs) with different exposure and risk profiles. In this context, rigorous methods to develop and validate psychometrically sound self-report instruments to measure consumers’ responses to TNPs are needed. Methods. Consistent with best practice guidelines, including the U.S. Food and Drug Administration’s “Guidance for Industry Patient-Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims,” scientifically designed, fit-for-purpose, reliable, and valid instruments are now being applied to tobacco regulatory research. Results. This brief report presents the ABOUT™ Toolbox (Assessment of Behavioral OUtcomes related to Tobacco and nicotine products) initiative. This communication: (1) describes the methodological steps followed for the development and validation of the measurement instruments included in the ABOUT™ Toolbox, (2) presents a summary of the high-priority tobacco-related domains that are currently covered in the ABOUT™ Toolbox (i.e., risk perception, dependence, product experience, health and functioning, and use history), and (3) details how the measurement instruments are made accessible to the scientific community. Conclusions. By making the ABOUT™ Toolbox available to the tobacco research and public health community, we envision a rapidly expanding knowledge base, with the goals of (1) supporting consumer perception and behavior research to allow comparisons across a wide spectrum of TNPs, (2) enabling public health and regulatory communities to make better-informed decisions for future regulation of TNPs, and (3) enhancing surveillance activities associated with the impact of TNPs on population health.
AVALIAÇÃO FÍSICO-QUÍMICA E QUANTIFICAÇÃO DE METAIS POTENCIALMENTE TÓXICOS EM ÁGUAS SUPERFICIAIS DO RIO JAURU
Authors: Da Silva Geilson Rodrigues , De Oliveira Hygor Rodrigues , Da Cruz Taniel Ferreira , Gandra Lucas Pereira 
Published: December 2018

O Rio Jauru compõe a bacia do Alto Taquari que junto com a bacia do Baixo Taquari representam um dos principais afluentes do Rio Paraguai, responsável pelo ciclo das águas no bioma do pantanal. Ao longo do Rio Jauru existem jazidas de minerais e pequenos garimpos, além disso na região, localizam-se grandes lavouras de soja e milho que empregam agrotóxicos, podendo ocasionar contaminações ambientais. Diante disso é importante o emprego de legislações para reger os parâmetros de qualidade das águas, visto que o Rio Jauru abastece o vilarejo a sua margem. Com isso, verificou-se os seguintes parâmetros físico-químicos (pH, alcalinidade, oxigênio dissolvido, condutividade elétrica, turbidez, sólido totais dissolvidos, cor verdadeira e dureza total) e quantificação dos metais (Ni, Cd, Cu, Mn e Pb) nas águas superficiais do Rio Jauru. As amostras foram obtidas em três pontos de coleta no decorrer de três meses consecutivos. As determinações físico-químicas foram realizadas a partir de adaptação de métodos disponíveis na literatura e a avaliação de metais ocorreu pela técnica da Espectrometria de Absorção Atômica em Chama. Apenas a cor verdadeira apresentou concentrações acima do permitido pela legislação enquanto o cobre foi o único metal que apresentou concentração acima do permitido. Os resultados expostos no presente estudo, não apontaram para uma contaminação ambiental nos pontos e nos meses de análise.
DE QUEM É O CURRÍCULO? PROBLEMATIZAÇÕES POR UMA EDUCAÇÃO NÃO SOBERANA
Authors: Gomes Larissa Ferreira Rodrigues , Gomes Helder Januário da Silva 
Published: December 2018

O presente artigo objetiva problematizar movimentos soberanos de dogmatização do currículo e das linhas ‘parresiastas’ dos estudantes brasileiros, que impulsionam a questionar de quem é o currículo? Debate sobre os conceitos de ‘Polícia soberana’ e ‘sociedade do espetáculo’ (AGAMBEN, 2015), e ‘sujeição social e servidão maquínica’ (LAZZARATO, 2014). Para tanto, assume como metodologia o acompanhamento cartográfico dos processos políticos produzidos em escolas públicas de Ensino Médio do Estado do Espírito Santo durante a Primavera secundarista. Como procedimentos metodológicos utiliza as imagens locais e nacionais divulgadas pela imprensa e as enunciações dos estudantes resistentes à reforma do Ensino Médio no Espírito Santo. Conclui afirmando que ao contestar o que está dado, os estudantes apontam que a escola e o currículo buscam em suas lutas e desejos a formação da existência “militante”, indagando sobre as estruturas políticas no interior das quais será capaz de afirmar a sua singularidade e a diferença.
The vast and omnivorous cloud
Authors: Stuart Thomas M. 
Published: December 2018

Abstract
Although it seems to promise an immaterial, unmediated, almost supernatural collapse of space at the user’s convenience, the cloud is not a solely spectral space. This introduction examines the cloud as a material object, a network of physical networks. It argues that inherent in the cloud’s nature as an internetwork is an excess, an overwhelming capacity to connect, reorganize and integrate. The physical nature and user experience of the Internet presents an uncontrolled, networked mediation of our personal lives, our history, our physical media and our orientation to the increasingly digital world. Examining popular digital horror, such as Slender Man, The Dionaea House (2006) and Kris Straub’s Ichor Falls (2009), alongside the articles collected in this special issue, this introduction argues that digital horror anxiously rehearses the cloud’s voracious capacity to incorporate that which should be left alone.