bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic identification of factors bound to isolated metaphase ESC chromosomes reveals a role for chromatin repressors in compaction
Authors: Djeghloul Dounia , Kohler Anne-Céline , Patel Bhavik , Kramer Holger , Veland Nicolas , Whilding Chad , Dimond Andrew , Elliott James , Feytout Amelie , Bharat Tanmay A.M. , Tarafder Abul K. , Löwe Jan , Ng Bee L. , Guo Ya , Brown Karen , Guy Jacky , Merkenschlager Matthias , Fisher Amanda G. 
Published: August 2019

AbstractEpigenetic information is transmitted from mother to daughter cells through mitosis. To identify trans-acting factors and cis-acting elements that might be important for conveying epigenetic memory through cell division, we isolated native (unfixed) chromosomes from metaphase-arrested cells using flow cytometry and performed LC-MS/MS to determine the repertoire of chromosome-bound proteins. Quantitative proteomic comparisons between metaphase-arrested cell lysates and chromosome-sorted samples revealed a cohort of proteins that were significantly enriched on mitotic ESC chromosomes. These include pluripotency-associated transcription factors, repressive chromatin-modifiers (such as PRC2 and DNA methyl-transferases) and proteins governing chromosome architecture. We showed that deletion of PRC2, DNMT1/3a/3b or Mecp2 provoked an increase in the size of individual mitotic chromosomes consistent with de-condensation, as did experimental cleavage of cohesin complexes. These data provide a comprehensive inventory of chromosome-bound factors in pluripotent stem cells at mitosis and reveal an unexpected role for chromatin repressor complexes in preserving mitotic chromosome compaction.
A versatile nanoreactor for complementary in situ X-ray and electron microscopy studies in catalysis and materials science
Authors: Fam Yakub , Sheppard Thomas L. , Becher Johannes , Scherhaufer Dennis , Lambach Heinz , Kulkarni Satishkumar , Keller Thomas F. , Wittstock Arne , Wittwer Felix , Seyrich Martin , Brueckner Dennis , Kahnt Maik , Yang Xiaogang , Schropp Andreas , Stierle Andreas , Schroer Christian G. , Grunwaldt Jan-Dierk 
Published: August 2019

Two in situ `nanoreactors' for high-resolution imaging of catalysts have been designed and applied at the hard X-ray nanoprobe endstation at beamline P06 of the PETRA III synchrotron radiation source. The reactors house samples supported on commercial MEMS chips, and were applied for complementary hard X-ray ptychography (23 nm spatial resolution) and transmission electron microscopy, with additional X-ray fluorescence measurements. The reactors allow pressures of 100 kPa and temperatures of up to 1573 K, offering a wide range of conditions relevant for catalysis. Ptychographic tomography was demonstrated at limited tilting angles of at least ±35° within the reactors and ±65° on the naked sample holders. Two case studies were selected to demonstrate the functionality of the reactors: (i) annealing of hierarchical nanoporous gold up to 923 K under inert He environment and (ii) acquisition of a ptychographic projection series at ±35° of a hierarchically structured macroporous zeolite sample under ambient conditions. The reactors are shown to be a flexible and modular platform for in situ studies in catalysis and materials science which may be adapted for a range of sample and experiment types, opening new characterization pathways in correlative multimodal in situ analysis of functional materials at work. The cells will presently be made available for all interested users of beamline P06 at PETRA III.
Steric and electronic evaluations of P(o-tol)R
2, where R is phenyl or cyclohexyl: crystal structures of SeP(o-tol)R
2
Authors: Davis Wade L. , Muller Alfred 
Published: August 2019

The crystal structures of SeP(o-tol)R
2, where o-tol is ortho-tolyl (2-methylphenyl) and R is Ph (phenyl), namely (2-methylphenyl)diphenylphosphane selenide, C19H17PSe, or Cy (cyclohexyl), namely dicyclohexyl(2-methylphenyl)phosphane selenide, C19H29PSe, were determined to aid in the evaluation of the steric and electronic behaviour of these analogous phosphane compounds. The compounds crystallized in similar monoclinic crystal systems, but are differentiated in their unit cells by a doubling of the number of independent molecules for R = Cy (Z′ = 2) and the choice of glide plane by convention. The preferred orientation for the o-tolyl substituent obtained from the X-ray structural analysis is gauche for R = Ph and anti for R = Cy (using the Se—P—C
ipso
—C
ortho
torsion angles as reference). Density functional theory (DFT) calculations showed both conformations to be equally probable and indicate that the preferred solid-state conformer is probably due to the minimization of repulsion energies, resulting in a packing arrangement primarily featuring weak C—H...Se interactions and additional C—H...π interactions in the R = Ph structure. A detailed electronic and steric analysis was conducted on both phosphanes using Se—P bond lengths, multinuclear NMR 1
J
Se–P coupling constants, theoretical topological evaluation and crystallographic and solid-angle calculations, and compared to selected literature examples. The results indicate that the use of the o-tolyl substituent increases both the electron-donating capability and the steric size, but is also dependent on whether the o-tolyl group adopts a gauche or anti conformation. The single-crystal geometrical data are unable to detect electronic differences between these two structures due to the somewhat large displacement parameters observed for the Se atom in the R = Cy structure.
A crisis of consumers’ trust in scientists and its influence on consumer attitude toward genetically modified foods
Authors: Deng Haiyan , Hu Ruifa 
Published: August 2019

Purpose
The purpose of this paper is to examine Chinese consumers’ attitudes toward genetically modified (GM) foods and the impact that consumers’ trust in different actors – GM scientists, non-GM scientists or individuals, the government and the media, has on their attitudes.

Design/methodology/approach
Consumers in Beijing were surveyed about their attitudes toward GM foods and their trust in different actors. The surveys were conducted from June to July of 2015. The sample size is 1,460 people. Given the potential endogeneity of trust variable, bivariate probit models are employed to estimate the impact of trust in different actors on consumers’ attitudes.

Findings
The results show that 55 percent of the Chinese consumers are opposed to GM foods and nearly 60 percent do not trust GM scientists. In total, 42 percent of Chinese consumers trust in the government and 39 percent trust the non-GM scientists or individuals. Around 35 percent of consumers believe the misinformation on GM technology that were provided by the media. Trust in the GM scientists and trust in the government have a significant positive impact on consumers’ acceptance of GM foods while trust in the non-GM scientists or individuals and believing the misinformation have a significant negative effect on the acceptance. Nearly 70 percent of Chinese consumers acquired information about GM food safety from the internet or via WeChat. Consumers who acquired GM technology information from the internet or via WeChat are less likely to embrace GM foods than those who obtain information from other sources.

Originality/value
Consumer trust plays a crucial role to accept biotech products in the market and it is crucial for producers, policy makers and consumers to have faith in new biotech products. The results of this study suggest that the government and GM scientists should make more effort to gain the trust and support of consumers, while the media should provide objective reports on GM products based on scientific evidence.
Are library electronic resources providing adequate support for research? A case study of a federal university in the United Arab Emirates
Authors: Ho Lilly Hoi Sze 
Published: August 2019

Purpose
Middle Eastern universities have recently been included in international rankings, driving a shift in priorities from teaching to research. However, research-centric collection assessments are rarely applied in the region. The Library and Learning Commons of Zayed University has recently completed the first phase of collection assessment for this transition. This study aims to provide an overview of how electronic resources adequacy was measured, and correlations between utilization of resources and research output were determined. A systematic approach is presented to assess electronic resources impact and to investigate and demonstrate the Library’s support of research output in local research and the scholarly environment.

Design/methodology/approach
Journal article publications from 2009 to 2016 with at least one Zayed University affiliated author were collected from Scopus, the abstract and citation database operated by Elsevier BV. Sources used within these articles were analyzed. COUNTER usage statistics of three indicators (searches, sessions and full-text downloads) were collected from the most used electronic resources in the Library to define the correlation between usage and research activities in the university during the assessment period.

Findings
The change in university direction toward research is apparent in the data since Fall 2014. Since then, faculty publication output grew rapidly and was positively correlated with library resources use. Sessions and searches displayed a strong positive relationship with research output while the correlation with full-text downloads was moderate. This was true for individual colleges as well as for the university as a whole, supporting the assumption that library utilization is highly correlated with the growth of research productivity.

Practical implications
Results of this assessment were used to justify the budget allocation of Zayed University Library for supporting research and improve the focus of collection development to better meet researchers’ needs. The most important outcomes were to provide evidence-based information to Library management for strategic planning and evaluation of their changing role in the digital age.

Originality/value
The systematic approach described has enabled Zayed University library to assess the relevance of its resources to its changed focus toward research, both for the university as a whole and among the more research-productive colleges. This initial approach may be useful for other libraries going through a similar transition, particularly within the region.
Of locals and insiders
Authors: Kuipers Erin Hedwig Christina , Desportes Isabelle , Hordijk Michaela 
Published: August 2019

PurposeThrough the case of the response to the 2017 Mocoa mudslide, the purpose of this paper is to contribute to a deeper understanding of why and how humanitarian response should be locally led, particularly in more complex contexts such as those affected by conflict.Design/methodology/approachThe study draws on qualitative data collected during a four-month period in 2017, with a focus on the immediate April 2017 emergency phase which presented the largest diversity of local, national and international actors.FindingsThe study has found that competing legitimacy claims between the state and non-state response blocs led to tensions and confrontations between disaster response actors and consequently a problematic response process and outcome. The institutional map that was plotted based on locally perceived actor legitimacies indicates a local state-led response would have better served the broader goals of humanitarian support, development and peacebuilding.Practical implicationsThese findings have significant implications for the understanding of how the locally led response should be understood. Better alignment with local needs and feasibilities requires a differential outlook on what is to be understood as “local.” This study puts forward the insider/outsider lens as a tool to identify the actors who possess local trust and legitimacy and are thus best suited to bridge the elements of the humanitarian-development-peacebuilding triple nexus.Originality/valueThis study gives a voice to state actors, which was largely absent in previous studies.
Practical evaluation of a reference architecture for the management of privacy level agreements
Authors: Diamantopoulou Vasiliki , Mouratidis Haralambos 
Published: August 2019

Purpose
The enforcement of the General Data Protection Regulation imposes specific privacy- and -security related requirements that any organisation that processes European Union citizens’ personal data must comply with. The application of privacy- and security-by-design principles are assisting organisation in achieving compliance with the Regulation. The purpose of this study is to assist data controllers in their effort to achieve compliance with the new Regulation, by proposing the adoption of the privacy level agreement (PLA). A PLA is considered as a formal way for the data controllers and the data subjects to mutually agree the privacy settings of a service provisioned. A PLA supports privacy management, by analysing privacy threats, vulnerabilities and information systems’ trust relationships.

Design/methodology/approach
However, the concept of PLA has only been proposed on a theoretical level. To this aim, two different domains have been selected acting as real-life case studies, the public administration and the health care, where special categories of personal data are processed.

Findings
The results of the evaluation of the adoption of the PLA by the data controllers are positive. Furthermore, they indicate that the adoption of such an agreement facilitates data controllers in demonstrating transparency of their processes. Regarding data subjects, the evaluation process revealed that the use of the PLA increases trust levels on data controllers.

Originality/value
This paper proposes a novel reference architecture to enable PLA management in practice and reports on the application and evaluation of PLA management.
Searching for trustworthiness: culture, trust and negotiating new business relationships
Authors: Brett Jeanne M. , Mitchell Tyree 
Published: August 2019

Purpose
This study aims to address three important but under-researched questions in the trust and negotiation literature: What do negotiators do to determine the trustworthiness of a potential business partner? What trust criteria motivate their search and help them interpret the information their search reveals? Whether there are systematic cultural differences in search and criteria, and if different, why?

Design/methodology/approach
This study used qualitative methodology. The data are from interviews with 82 managers from 33 different national cultures in four regions of the world identified by cultural levels of trust in negotiation and tightness-looseness. Interviews focused on how negotiators determined the trustworthiness of potential business partners in intracultural negotiations.

Findings
Analyses revealed four search activities negotiators use to gather information about a potential business partner: due diligence, brokerage, good will building and testing; and five criteria for determining the trustworthiness of a new business partner: respect, mutual values, competence, openness and professionalism. Quotes illustrate how these search activities and criteria manifest in different cultures.

Research limitations/implications
This study used multiple cases to build a longitudinal picture of the process. It did not follow a single case in depth. The study focused on identifying cultural central tendencies at the same time recognizing that there is always variability within a culture.

Practical implications
Knowing what is culturally normative allows negotiators to anticipate, interpret and respect their counterpart’s behavior. Such knowledge should facilitate trust development.

Originality/value
This study provides an in-depth understanding of cultural similarities and differences in the process of trust development in negotiating new business relationships.
Strength, fatigue and bagging properties of plated plain knitted fabrics containing different rates of elastane
Authors: Uyanik Seval , Kaynak Kubra Hatice 
Published: August 2019

Purpose
Elastane yarns contribute significant elastic properties to all types of fabrics and these properties for very important for wears including tights, sportswear, under wear, casual wear, swimwear, corsetry, etc. in terms of appearance, comfort and duration of wear. The paper aims to discuss this issue.

Design/methodology/approach
It is investigated with this study strength, fatigue and bagging properties of plated plain knitted fabrics containing different rates of elastane.

Findings
The study showed that single jersey, not having elastane and having the lowest fabric tightness, has the lowest bursting strength, the highest fatigue loading values in high extensions, the lowest fatigue height values and the worst bagging behavior. On the contrary of single jersey, full elastane fabric has the exact opposite characteristics considering the fabric properties examined.

Originality/value
Fabric with 1×1 elastane and fabric with 2×1 elastane is similar, and these fabrics show bagging behavior better than single jersey and worse than full elastane fabric whereas the other properties of these fabrics are close to full elastane fabric.
Lessons from the field for community engagement and accountability
Authors: Berland Alex 
Published: August 2019

Purpose
In Canada, community engagement and accountability are a political imperative, resulting in an omnipresent program with varied opportunities for public participation. The purpose of this paper is to promote leadership and commitment for health system transformation that truly benefits communities.

Design/methodology/approach
This paper is based on the author’s experience with many engagement and accountability activities, applied in varied settings, for purposes such as evaluation, planning, policy making and system transformation. The specific context is generalized with international experiences and references.

Findings
The “lessons learned” are based on practical considerations with relevance for both novice and experienced practitioners: clarifying principles, processes and purposes at the outset; using effective leadership to achieve the desired impact; using a variety of methods to engage communities; clarifying engagement and accountability roles precisely; measuring things that are meaningful; and consulting with internal as well as external communities. Also, community leaders should recognize effort as well as results.

Research limitations/implications
Commitment to engagement and accountability is commendable – but is it enough? The paper concludes by looking beyond health system impacts to propose a broader systems perspective. If clinical governors want to use engagement and accountability to achieve “total value” for their communities, they will need to demonstrate as leaders that they are committed to long-term thinking and broad social goals.

Originality/value
Too much focus on the process of care may mask accountability for reporting outcomes or systemic impact. The sustainable development goals highlight the need for systems thinking and public expectations include corporate social responsibility. As shown in the examples cited, a deeper commitment to engagement and accountability requires looking beyond care delivery to social determinants and to systemic impacts of the health care industry itself.
Digital learning approaches in an intermediate-level computer science course
Authors: Apiola Mikko , Lokkila Erno , Laakso Mikko-Jussi 
Published: August 2019

Purpose
Digital learning has become a global trend. Partly or fully automatic learning systems are integrated into education in schools and universities on a previously unseen scale. Learning systems have a lot of potential for re-education, life-long learning and for increasing access to educational resources. Learning systems create massive amounts of data about learning behaviour. Analysing that data for educational decision making has become an important track of research. The purpose of this paper is to analyse data from an intermediate-level computer science course, which was taught to 141 students in spring 2018 at University of Turku, Department of Future Technologies, Finland.

Design/methodology/approach
The available variables included number of submissions, submission times, variables of groupwork and final grades. Associations between these variables were looked at to reveal patterns in students’ learning behaviour.

Findings
It was found that time usage differs per different grades so that students with grade 4 out of 5 used most time. Also, it was found that studying at night is connected to weaker learning outcomes than studying during daytime. Several issues in relation to groupwork were revealed. For example, associations were found between prior skills, preference for individual vs groupwork, and course learning outcomes.

Research limitations/implications
The research was limited by the domain of available variables, which is a common limitation in learning analytics research.

Practical implications
The practical implications include important ideas for future research and interventions in digital learning.

Social implications
The importance of research on soft skills, social skills and collaboration is highlighted.

Originality/value
The paper points a number of important ideas for future research. One important observation is that some research questions in learning analytics need qualitative approaches, which need to be added to the toolbox of learning analytics research.
A critical evaluation of the public sector improvement framework
Authors: Rodgers Bryan , Antony Jiju , Penman Derek 
Published: August 2019

Purpose
The purpose of this paper is to critically evaluate the use of the public sector improvement framework (PSIF) across public sector agencies in Scotland and explore the research gaps and consequent questions which arise. It is considered that the national promotion of a methodology for public sector improvement, while entirely legitimate, deserves independent scrutiny.

Design/methodology/approach
The assertions of purpose and effectiveness of PSIF made by both the Improvement Service and European Foundation for Quality Management (EFQM) have been critically examined and independent research which would support or challenge those assertions has been explored.

Findings
There are significant research gaps in the published literature which raise considerations around not only the effective deployment of EFQM but also the requirement for PSIF. The question whether there is a requirement to adapt EFQM for the public sector is also raised.

Research limitations/implications
This paper explores published academic research and does not reference any internal research undertaken by either the Improvement Service or EFQM.

Practical implications
Practitioners who have implemented or are considering implementing PSIF should do so from an informed perspective and be aware of the apparent lack of published research and the significant gaps and questions raised through this paper.

Originality/value
No published research on PSIF and its adaptation from the EFQM business model has been identified. Given the investment and impact of implementing PSIF organisation wide, it is considered extremely valuable to raise these questions for practitioners, as well as encourage the academic community in undertaking research in this area.