bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of toxicness of snails meat on biological model
Authors: Danilova I. S. 
Published: July 2019

Snails can be found in any part of the planet. They belong to the class of gastropods, which includes terrestrial, freshwater, marine snails. Their ancestors are some of the most ancient species of the fauna. Archaeologists say that the first lived on our planet 500 million years ago. There are about 90000 species of snails, but only 3 species have gained worldwide fame: gigantic African snail, grape and Helix аspersa. Snail’s meat improves bowel function and normalizes metabolism. It is believed that due to the content of magnesium, snail meat has calming effect on humans and helps to fight stress. To determine the level of toxicity of food snails meat on a biological model. Helix pomatia snails were collected in wet weather, after rain or in the morning, Helix aspersa maxima and Helix aspersa muller were recieved from the farm “SNAIL 2016” (Ukraine). As a model we used white mise. To determine the toxicity, the sampled meat preparation has been conducted. For this purpose an average sample of meat of each snail types of 10.0 g, carefully chopped. The milled sample of 5.0 g was introduced into a sterile glass, poured 50.0 cm3 of distilled water, stirred and filtered. There were formed experimental 6 and 2 control groups of mice were formed by six in each one, of 2 months of age (body weight 20 g). Subsequently, prepared samples of snails meat were injected into the mice stomach through a probe every day for 3 days by 0.5 cm3. As a probe, a thin, single-use micropipette was used. The white mice of each group experimental of all groups were placed in isolated cages and clinically monitored for five days. The mice didn’t recieved food, animals had free access to water. Mice of the control groups had free access to food. The meat of each type of snails in the experiments was used both fresh and after 7 days storage refrigerator at a temperature of 4 °С. It was found that filtrates from fresh meat of the three types of food snails Helix aspersa maxima, Helix aspersa muller and Helix pomatia were non-toxic, for the mice of I, II and III groups. We have noticed that the meat that was stored for 7 days in the refrigerator at a temperature of 4 °C was toxic. Mice of the V–VII groups that were fed such meat had a depressed state, muscle tremor, they refused of water and died on 2nd and 3rd days. The mise of control groups (IV and VIII) remained during all experience remained living. This work can be used as a method for determining the toxicity of snail’s meat. It is technologically simple, it requires only laboratory animals, namely white mice, does not require special equipment. Only 3 days can get the result. The method can be used in the work of scientific-experimental, production and regional laboratories of veterinary medicine.
Histostructure of the internal organs and skin of rats for the long-term effect of the drug “VetMikoDerm”
Authors: Martynyshyn V. P. 
Published: July 2019

The investigation of the skin toxicity of the liniment “VetMikoDerm” for prolonged use was performed on young and healthy laboratory rats with intact skin, body weight 200–220 g. The investigated environment was applied to a clean, non-woolly area (dorsal/lateral surface) of at least 10% of the total surface area. The spotted thistle oil was applied to the pre-prepared area of the skin of the animals of the control group, and the other two experimental groups of animals got the studied drug at the doses of 50 (I) and 500 mg/kg (II), respectively. The drug was applied to the skin daily for 28 days. At the end of the experiment, after the decapitation of the rats conducted under the light etheric anesthesia, a complete pathoanatomical dissection was performed, the coefficients of the mass of the internal organs were determined, samples of liver, kidney and skin tissues were taken for their histological examination. According to the results it was established that the liver and kidneys histology, and skin of rats of the 1st experimental group were similar to those that were of the control animals. At the same time, receiving the maximum dose (10 times the therapeutic dose) of the drug “VetMikoDerm”, the majority of rats of the 2nd group showed a discomplication of the lamellar structure of the liver lobules, hepatocytes were placed in separate groups, sinusoidal capillaries were expanded. The presence of hepatocytes with heterogeneous, granular and weakly colored cytoplasm was observed in the central parts of the lobules, the nuclei of individual hepatocytes were increased, indicating the development of granular protein degeneration of the parenchyma. Histologically, under these conditions, foci of granular dystrophy of the epithelium of the vorticular and direct renal tubules with the expansion of their lumen were found in the structure of kidney of rats. The kernels of individual nephropyelitis had signs of karyopicnosis and cariorexis. The histological structure of skin of rats in all experimental groups was of the same type and consisted of the epidermis, dermis and hypodermis. Animals of the 2nd experimental group which repeatedly and for a long time were applied a “VetMikoDerm” lineulation in a dose that exceeded its optimal amount by 10 times showed the epidermal thickening, the presence of small-mesenchymal polymorphocytic infiltration, microcirculatory corneal disorder and sebaceous gland hyperplasia glands in the dermis that indicated the development of a compensatory-adaptive reaction in places of application of a 10-fold dose of the investigational medicinal product.
The influence of conditions of detention the hoof and the development of aseptic inflammation of the producing layer of the base of the skin soles hooves in the cows
Authors: Khomyn N. M. , Mysak A. R. , Tsisinska S. V. , Pritsak V. V. , Lenyo Yu. M. , Khomyn M. M. 
Published: July 2019

Violation of the conditions of animals keeping and the lack of proper level of veterinary and sanitary culture on farms does not allow to achieve a balance between the organism of the cattle and the environment of its stay. The uneven distribution of body weight on the surface of the sole caused by keeping animals on a rough floor promotes the emergence of producing corns, stretching of the tendons and ligaments, slippery flooring leads to the fall of animals and the occurrence of various injuries, in particular, fractures of the limbs, tensile bond, capsule of the joint, excessively hard floor – to excessive erosion of the horn of the sole, etc. In such herds it is difficult to maintain animal health at the proper level and prevent the occurrence of, in particular, aseptic pododermatitis. The article deals with the results on the dissemination of aseptic pododermatitis in cows for the presence of animals on wooden and reinforced concrete slit floors during the winter and standstill period of containment. It has been established that aseptic pododermatitis in cows on reinforced concrete slit floor is registered in 71.6% of cases, while on wooden – only 28.4%. In the hoof horn of the thoracic and pelvic extremities of the cows, with aseptic pododermatitis, the amount of moisture decreased by 8.2 and 9.3% respectively, the concentration of SH-groups increases by 10.6 and 15.8%, with a possible decrease in the content of calcium, sulfur, cuprum and zinc; decreases the hoof horn density and resistance to abrasion of the epithelium of the hooves of the pelvic limbs by 1.6 and 18.0%, as well as the intensity of the abrasion sole hooves of the thoracic and pelvic limbs is increased by 7.5 and 20.0%, which helps to reduce the growth of the epidermis of the sole. Consequently, changes in certain biochemical and biophysical indices of hoof horns of cows suffering from aseptic pododermatitis, which were held on the reinforced concrete slit, indicate a deterioration in the quality of the epidermal hooves and excessive erosion of the sole, which is one of the causes of the occurrence and development of aseptic pododermatitis in cows.
Al-Tafkir Al-Lughawi Indal Arab
Authors: Malla Agussalim Beddu , Ismail Usman 
Published: July 2019

Sejak munculnya Agama Islam perhatian terhadap bahasa sangat besar artinya ini disebabkan karena tak satupun pembahasan dalam kajian keislaman baik itu fiqih, tafsir, hadits yang tidak menggunakan bahasa sebagai acuan pertama dan utama. Seiring dengan munculnya ilmu filsafat kedalam kajian Islam maka bahasa mengalami perkembangan yang luar biasa sebagaimana kita saksikan pada abad kedua dan ketiga hijriah, lahirnya para pakar ilmu bahasa yang membahas bahasa dari segala aspek, bukan hanya aspek nahwu, saraf semata tapi sudah masuk ke pembahasan filsafat bahasa bahkan akhirnya munculah macam-macam kajian bahasa seperti sosiolinguistik, psikolinguistik, dll. Hal ini membuat para pengkaji baik bahasa baik di timur tengah maupun di Barat terjadi saling melengkapi.
Improve Students’ Skills in Listening Comprehension by Using Song Based on Multimedia
Authors: Jannah Hariratul , Abdollah Abdollah , Majid Syahria 
Published: July 2019

In order to improve the quality of learning English, especially listening skills, students of the English Literature Study Program and the English Language Education Study Program submitted the research title "Improving the Skill of Student Multimedia Comprehension Listening Through Multimedia-Based Song Media." The specific objectives of this study were to: 1) improve listening skills in English-speaking students of the English Language and Literature Study Program at the Faculty of Letters of UMI; 2) developing listening learning models with multimedia-based song media. This research was conducted in the UMI English Literature and English Language Education Study Program at the Faculty of Letters with targeted results as follows: 1) in one year this was a valid draft model for learning listening with multimedia-based song media. The method used in this study is action research with a population of 156 students. This study produced a draft listening comprehension model, the results of the study showed that the learning process of Listening comprehension used multimedia-based songs with subtitles of positive student responses. From the questionnaire / questionnaire / close questionnaire shows ≥ 75% of students respond more easily and prefer the learning process to understand meaning and understand what is heard from native speakers in learning listening comprehension. This study recommends for listening lecturers to use songs as one of the media in learning that will improve student skills
Development of an indirect ELISA for detection of antibody against peste des petits ruminants virus in sheep
Authors: Sumi F. S. , Nooruzzaman M. , Rahman M. M. , Islam M. R. , Chowdhury E. H. 
Published: July 2019

Background: Emergence of exotic viral disease like peste des petits ruminants(PPR) possesses a great threat towards successful goat and sheep farming in Bangladesh. Implementation of effective control measures against PPR requires a proper and rapid diagnosis of the disease. Various diagnostic techniques are available for diagnosis of PPR in goats and sheep in Bangladesh. Among these, ELISA is an important technique to diagnose the disease as well as for seromonitoring. However, the ELISA kits that are being used in the country are mostly imported. This study was undertaken to develop an in-house indirect ELISA using local PPR virus isolate as an antigen.Methods: A local isolate of PPR virus (PPRV) was used as an antigen to develop an indirect ELISA kit. Standardization of the optimum antibody, conjugate and virus antigen concentration was performed using chequer-board titration with different dilutions of the reagents. Finally, the developed indirect ELISA kit was used in a pilot study to detect anti-PPRV antibodies in sheep sera samples.Results: A polyclonal antibody based indirect ELISA was developed successfully for the detection of PPRV antibodies. The developed ELISA could detect anti-PPRV antibody in sheep sera sample during our pilot field trial.Conclusions: After robust field validation, the indirect ELISA can be used to determine the antibody titer against PPRV in the field as to monitor the seroconversion after vaccination.
Effect Application of Technique Partial Rootzone Drying (PRD) on the Growth, Yield and Quality of Tomatoes
Authors: Idris Muhammad , Hutagaol Dermawan , Ani Nurma 
Published: July 2019

The research was conducted to evaluate the performance of tomatoes varieties on growth, yield and quality through the application of partial rootzone drying. The study was conducted in green house at the Faculty of Agriculture Universitas Islam Sumatera Utara (UISU) Medan in May 2014 until September 2014. The planting media used were straw compost mixed with top soil enriched withUrea, SP ─ 36 and KCL fertilizer filled into polybeg up to 10 kg in weight. Observation variables are: the growing, yield and quality of tomato
The Effect of Perchloroethylene (PCE) Exposure Toward Frequency of Micronucleus Formation in Buccal Mucosal Ephitelia of Dry Cleaning Employees
Authors: Julianti Rosmayda Ria , Brahmadhi Ageng , Romdhoni Muhammad Fadhol , Riyanto Refni 
Published: July 2019

Background: Perchloroethylene is one of the main ingredients used in the dry cleaning industry. Continuous inhalation of Perchloroethylene particles can cause genetic damage that can be marked by the appearance of micronucleus. Micronucleus formation of excessive buccal mucosal is one of the early signs of malignancy in the oral cavity.
Objective: To determine the effect of Perchloroethylene exposure toward frequency of micronucleus formation in buccal mucosal epithelial of dry cleaning employees in Banyumas Regency.
Materials & methods: This study uses cross-sectional design with primary data that is the preparation of buccal mucosal smear from 22 dry cleaning employees as exposed group and 22 subjects are not exposed to Perchloroethylene as control group. The buccal epithelial cells are collected using a spatula and then smeared on an object glass and colored using Giemsa. Micronuclear frequencies are calculated per 1000 cells using a light microscope.
Results: The difference of micronucleus frequency between two groups (p = 0.000) is obtained. The duration of work has correlation with medium correlation strength to the forming frequency of micronucleus formation, whereas age has strong correlation to the forming frequency of micronucleus formation. The correlation between age and work duration with the forming frequency of micronucleus formation is significant (p = 0.000 and p = 0.07)
Conclusions: There is influence of Perchloroethylene exposure toward frequency of micronucleus formation. The duration of work and age are significantly correlated with the forming frequency of micronucleus formation.
J MEDICINE JUL 2019; 20 (2) : 59-62
Cox Proportional Hazard Regression for Risk Factors of Alzheimer’s Disease
Authors: Hosseinioun Nargess 
Published: July 2019

Background: Alzheimer’s disease is a form of dementia, mainly strikes people in their 60 and 70s. While no one cause has been determined, researchers have identified certain factors which may put people at a higher risk of developing the disease. Iran’s Alzheimer Association has announced that more than 35% of people over 80 years old suffers from this problem across the country. This paper aims to investigate modifiable risk factors of Alzheimer’s disease based on Kaplan-Meier estimator and Cox regression analysis (proportional hazard model) and to find out which factors are related to developing of this disease.
Materials & methods: Residents newly admitted to nursing homes with a diagnosis of probable Alzheimer’s disease have been considered. Patients were at least 75 years of age from 9 Medicare/ Medicaid certified nursing homes of Khorasan and Tehran states and we excluded patients with a history of mental retardation, mental illness or any other long-life mental health disorders. This strategy yielded a sample of 115 patients (37 Males and 78 Females) with total death rate of 47%.
Results: Our findings demonstrate that Age, Gender, Heritage, Apoplexy, Mental and Physical Activities statistically affect Survival and also Hazard Rate, In contrast, we found no link between survival duration and a history of Addiction and Blood Pressure.
Conclusions: These findings have implications for clinical practice and intervention strategies in medical and public health.
J MEDICINE JUL 2019; 20 (2) : 72-79
Clinical Value of Serum Cancer Antigen 19-9 as a Tumor Screening Marker among Healthy Individuals
Authors: Biswas Prodip Kumar , Sardar Md Hafiz , Saha Gopal Chandra , Hossain Mohammed Shahadat , Rahman Mohammad Motlabur , Chowdhury Mostofa Kamal , Paul Tushit 
Published: July 2019

Background: Serum tumor markers are convenient, non-invasive, acceptable to patients and play an important role as an ancillary tumor diagnostic tool. CA 19-9 has become a common tumor marker, specific for digestive system tumors. The study was carried out to determine the value of CA 19-9 as a tumor screening marker among healthy individuals.
Materials and Methods: This study had been carried in Dhaka Medical college Hospital from January 2016 to January 2018. The serum CA 19-9 level was detected using a microsome luminescence method. Individuals with high CA 19-9 levels underwent further examination, including routine fecal testing, thoracic and abdominal computed tomography (CT) scan, gastroscopy, and colonoscopy. These individuals had regular follow-up examinations.
Results: Over a 3-year period, the serum CA19-9 levels of 960 healthy individuals were estimated. The CA 19-9 level of 15 individuals was positive (positive rate: 1.56%), including 7 men (7/699; 1.001%) and 8 women (8/261; 3.06%). There was a significant difference between males and females (p<0.01), The overall tumor detection rate was 0.72% (7/960) including 6/699 men (0.85%) and 1/261 women (0.38%).
Conclusion: Therefore, elevated CA 19-9 level can be used to assist in the diagnosis malignancy.
J MEDICINE JUL 2019; 20 (2) : 92-94
Identifikasi Bakteri Coliform Pada Air Minum Dalam Kemasan (AMDK) Yang Diproduksi Di Kota Batam
Authors: Amelia Fitrah 
Published: July 2019

Tujuan penelitian ini adalah untuk mengetahui ada atau tidaknya bakteri coliform beserta jenisnya, yang terkandung dalam air minum dalam kemasan yang diproduksi di kota Batam. Populasi dari penelitian ini adalah seluruh air minum dalam kemasan diproduksi di kota Batam. Teknik pengambilan sampel menggunakan purposive sampling. Sampel diambil dari 8 merek air minum dalam kemasan yang diproduksi di kota Batam. Penelitian ini dilakukan di laboratorium Central Teknologi laboratorium medik, STIKES Perintis, Padang. Terhadap sampel dilakukan identifikasi Coliform yang dilakukan dengan metoda MPN (Most Probable Number). Pengujian MPN dilakukan dengan dua tahap yaitu, Uji Praduga (Presumptive Test) menggunakan medium LB (Lactosa Broth) dan Uji Konfirmasi (Confirmative Test) menggunakan medium BGLB (Brillian green laktosa broth). Dari hasil penelitian diperoleh hanya 2 sampel yang tidak mengandung bakteri coliform. Nilai MPN berkisar antara 2 - ≥ 979 MPN/100 ml. Setelah dilakukan uji pelengkap dari 16 sampel yang dianalisa diperoleh 8 sampel mengandung bakteri diantaranya Klebsiella sp., Enterobacter, Pseudomonas sp., dan Salmonella sp.
PENANAMAN NILAI-NILAI PENDIDIKAN ISLAM MULTIKULTURAL DI PERGURUAN TINGGI KEAGAMAAN ISLAM (Studi Kasus di Universitas Islam Malang)
Authors: Anam Ahmad Muzakkil 
Published: July 2019

Indonesia adalah bangsa yang memiliki tingkat keberagaman yang sangat tinggi baik itu dalam hal suku, ras, etnis atau pun agama. Sehingga tidaklah berlebihan jika kemudian Indonesia dikenal sebagai bangsa yang multikultural. Sehingga, perlu adanya upaya untuk menanamkan nilai-nilai pendidikan multikultural di semua jenjang pendidikan yang ada di Indonesia, termasuk perguruan tinggi. Penelitian ini menggunakan pendekatan kualitatif dengan rancangan studi kasus.Teknik analisis data meliputi reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan, bahwa: 1) prinsip-prinsip penanaman nilai-nilai pendidikan Islam multikultural di Unisma didasarkan pada beberapa prinsip, yaitu: keterbukaan (openness), toleransi (tolerance), bersatu dalam perbedaan (unity in diversity), dan Islam rahmatan lil’alamin sebagai leader; 2) implementasi penanaman nilai-nilai pendidikan multikultural di Unisma terpolakan menjadi dua, yaitu multicultural knowing dan multicultural feeling.Multicultural knowing diberikan melalui beberapa kegiatan seperti Orientasi Kehidupan Kampus Mahasiswa Baru (Oshika Maba), Halaqoh Diniyah, dan Mata Kuliah Agama Islam 1-5. Adapun multicultural feeling ditanamkan melalui kegiatan student day; dan 3) penanaman nilai-nilai pendidikan multikultural di Unisma memiliki implikasi yang positif terhadap sikap toleransi para mahasiswa Unisma.
Cognitive behavioural treatment for insomnia in primary care: a systematic review of sleep outcomes
Authors: Davidson Judith R , Dickson Ciara , Han Han 
Published: July 2019

BackgroundPractice guidelines recommend that chronic insomnia be treated first with cognitive behavioural therapy for insomnia (CBT-I), and that hypnotic medication be considered only when CBT-I is unsuccessful. Although there is evidence of CBT-I’s efficacy in research studies, systematic reviews of its effects in primary care are lacking.AimTo review the effects on sleep outcomes of CBT-I delivered in primary care.Design and settingSystematic review of articles published worldwide.MethodMedline, PsycINFO, EMBASE, and CINAHL were searched for articles published from January 1987 until August 2018 that reported sleep results and on the use of CBT-I in general primary care settings. Two researchers independently assessed and then reached agreement on the included studies and the extracted data. Cohen’s d was used to measure effects on sleep diary outcomes and the Insomnia Severity Index.ResultsIn total, 13 studies were included. Medium-to-large positive effects on self-reported sleep were found for CBT-I provided over 4–6 sessions. Improvements were generally well maintained for 3–12 months post-treatment. Studies of interventions in which the format or content veered substantially from conventional CBT-I were less conclusive. In only three studies was CBT-I delivered by a GP; usually, it was provided by nurses, psychologists, nurse practitioners, social workers, or counsellors. Six studies included advice on withdrawal from hypnotics.ConclusionThe findings support the effectiveness of multicomponent CBT-I in general primary care. Future studies should use standard sleep measures, examine daytime symptoms, and investigate the impact of hypnotic tapering interventions delivered in conjunction with CBT-I.