bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anaesthetists’ Attitudes towards an Anaesthesia Simulator. A Comparative Survey: U.S.A. and Australia
Authors: Riley R. H. , Wilks D. H. , Freeman J. A. 
Published: January 2019

Anaesthesia simulation has been suggested as a method to enhance the training of clinicians without exposing patient to risk. Recently, two anaesthesia simulators have become commercially available in the U.S.A. Attitudes towards anaesthesia simulators have not been previously surveyed. With institutional approval, a survey questionnaire was given to 1. all clinical staff of the Department of Anesthesiology, University of Pittsburgh Medical Center; and 2. all anaesthetists attending the Annual General Meeting of the Australian Society of Anaesthetists. An information sheet containing details about anaesthesia simulation in general and the special capabilities of a particular commercial anaesthesia simulator was included with the survey instrument. The survey was anonymous and contained 15 questions. Attitudinal responses were recorded using an anchored visual analog 100 mm scale. We surveyed anaesthetists during September-October 1993. Completed forms were returned by 183 anaesthetists. Respondents were aged 25–67 years (mean age 41±10 yr) and were grouped by staff position (78% faculty, 22% trainees), sex (79% male, 21% female), country of practice (44% Aust, 56% U.S.A.) and years in practice. Seventy-three per cent staff were in favour (VAS>60) of departmental purchase of a simulator (with no significant difference between countries) and 76% expressed willingness (VAS>60) to undergo testing in their own time (with Australian anaesthetists significantly more willing to do so). However, 65% were not in favour (VAS <40) of the compulsory use of a simulator for re-certification or re-accreditation of anaesthesia practitioners, with American anaesthetists (anesthesiologists) significantly more opposed to it. The most frequent comment related to the cost. There is majority support for the purchase of an anaesthesia simulator but there is widespread concern for its high cost. In general, anaesthesia simulation is perceived more as an education tool rather than an instrument for (re)certification.
Tension Pneumopericardium following Tracheoplasty for Congenital Tracheal Stenosis
Authors: Sugimoto M. , Shimaoka M. , Hagihira S. , Fujino Y. , Nishimura S. , Kamata S. , Taenaka N. , Yoshiya I. 
Published: January 2019

Tension pneumopericardium is a rare complication of mechanical ventilation following tracheoplasty for congenital tracheal stenosis. This case report describes fatal tension pneumopericardium in a three-month-old male infant some 24 hours following tracheoplasty for this condition. Because of persisting stenosis of the left main bronchus, ventilation pressures of PIP 23 cm H2O and PEEP 5 cm, progressing to PIP 28 cm and PEEP 7 cm were needed to maintain adequate respiratory exchange. Partial relief of the pneumopericardium was achieved by vigorous cardiac massage, but three days later the infant died of massive airway haemorrhage.
Alleged Allergy to Local Anaesthetics
Authors: Fisher M. McD. , Bowey C. J. 
Published: January 2019

The aim of this study was to determine the incidence of true local anaesthetic allergy in patients with an alleged history of local anaesthetic allergy and whether subsequent exposure to local anaesthetics is safe. Two hundred and eight patients with a history of allergy to local anaesthesia were referred over a twenty-year period to our Anaesthetic Allergy Clinic. In this open study, intradermal testing was performed in three patients and progressive challenge in 202 patients. Four patients had immediate allergy and four patients delayed allergic reactions. One hundred and ninety-seven patients were not allergic to local anaesthetics. In 39 patients an adverse response to additives in local anaesthetic solutions could not be excluded. In all but one patient local anaesthesia has been given uneventfully subsequently. A history of allergy to local anaesthesia is unlikely to be genuine and local anaesthetic allergy is rare. In most instances LA allergy can be excluded from the history and the safety of LA verified by progressive challenge.
Infection in Central Lines: Antiseptic-Impregnated vs Standard Non-Impregnated Catheters
Authors: Loo S. , van Heerden P. V. , Gollege C. L. , Roberts B. L. , Power B. M. 
Published: January 2019

We report a survey of 196 consecutive central venous catheters (CVCs) placed in 151 patients in the Intensive Care Unit (ICU) over a ten-month period. Over this time the use of a new antiseptic-impregnated triple lumen CVC (Arrowgard Blue, Arrow International Inc., Pennsylvania, U.S.A.) was alternated on a bimonthly basis with the standard triple-lumen CVC (Arrow International Inc., Pennsylvania, U.S.A.). The overall rate of CVC tip infection was lower in the impregnated CVC group (15.6% vs 30.9%, P<0.05). The impregnated CVC group had a much lower cumulative infection rate when the dwell time in patients was five days or less (3.3% vs 26.9%, P<0.05). However, the difference between the cumulative infection rate was not statistically significant (P>0.05) for dwell times of 6, 7 or 8 days respectively. There was no difference in the CVC related bacteraemia rates between the two groups (3.9% vs 3.7%, P>0.05).
Graphic Data Representation in Anaesthesiological Journals: A Proposed Methodology for Assessment of Appropriateness
Authors: De Amici D. , Klersy C. , Tinelli C. 
Published: January 2019

Few authors have addressed the topic of graphic data presentation. The purpose of our study was to combine several guidelines in order to evaluate three anaesthesiology journals listed in Index Medicus (Australian, American and Italian) in terms of the appropriateness and the quality of presentation of graphs. Our analysis was based on concepts expressed by Cox and Tufte. We calculated the optimization of the amount of information in each graph using two parameters: Data Density Index (DDI) and Data Ink Ratio (DIR). The correctness and clearness of each component of the graph (scale, title, axes, legends and abbreviations) was evaluated on the basis of a binary score. We analysed 300 exploratory plots, quantitative graphs and summaries of statistical analysis. About 50% of papers had more than three graphs. Mean scores were 3.22 for the Italian journal, 3.47 for the American journal and 3.82 for the Australian journal. Tufte parameters were calculated on 42 scatterplots: DDI was 5.4±13.9 and DIR was 0.7±0.1. The criteria applied in our study appear sufficiently sensitive to differentiate the quality of graphs.
Basal Chronic Villitis and Disorders of the Placental Basal Plate: A Possible Immunological Link Between Hypertensive Disorders of Pregnancy and Morbidly Adherent Placenta
Authors: Katzman Philip J , Blitman Joseph , Metlay Leon A 
Published: January 2019

Background Hypertensive disorders of pregnancy (HDP) are a common cause for preterm delivery. Prior studies showed that chronic villitis (CV) is associated with intrauterine growth restriction, preeclampsia, intrauterine fetal death, and morbidly adherent placenta (MAP). The authors hypothesize that disorders of the placental basal plate, especially basal chronic villitis (BCV), are associated with HDP. Methods The laboratory information system was queried over 12 years to identify placentas with or without the clinical history of HDP and with or without multifocal/focal CV or BCV. As a control for tissue sampling, a similar search was performed over 5 years for placentas evaluated for MAP. Results Of 19,683 placentas identified, 14.8% had CV which was in 18.5% and 14.2% of placentas associated with or without HDP, respectively, a significant difference ( P < .0001). BCV was present in 6.0% and 3.9% of placentas with or without HDP, respectively, also a significant difference ( P < .0001). BCV was more likely than multifocal/focal CV to occur in HDP (32.4% vs 27.4%) when all cases of CV were analyzed ( P = .025). Of 221 placentas with MAP, 64% had multifocal/focal CV and 36% had BCV. Conclusions BCV and CV are more common in placentas with HDP than in normotensive pregnancies. They are also seen in MAP, as supported by another recent study.
Clinical Predictive Factors for the Efficacy of Everolimus in Patients With Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer: A Multicenter Retrospective Cohort Study in Japan
Authors: Kikawa Yuichiro , Kotake Takeshi , Kajiwara Yukiko , Hashimoto Kazuki , Yamashiro Hiroyasu , Ohtani Shoichiro , Takao Shintaro , Toi Masakazu 
Published: January 2019

Purpose: To investigate the clinical predictive factors for the efficacy of everolimus (EVE) for advanced/metastatic breast cancer (AMBC). Methods: Routine practice data of consecutive patients with AMBC who received EVE at 5 institutions in western Japan were retrospectively analyzed in this cohort study (study registration no.: UMIN 000032569). The correlation among time to treatment failure (TTF), overall survival (OS), and clinical background was investigated via univariate and multivariate analyses using Cox hazards model for the clinically important variables. Results: A total of 134 patients were included in the analysis. The median TTF and OS were 5.2 months (95% confidence interval [CI]: 4.1-6.4) and 27.3 months (95% CI: 23.7-30.9), respectively. Multivariate analysis showed that dose reduction of EVE from any initial dose was associated with a longer TTF (hazard ratio [HR]: 0.52; 95% CI: 0.32-0.84, P = .007). Meanwhile, very low hormone sensitivity (ie, relapse within the first 2 years during adjuvant endocrine therapy or progression within 3 months of endocrine therapy immediately before EVE) was associated with a shorter TTF (HR: 2.48; 95% CI: 1.49-4.10, P < .001). In the analysis of stratified treatment outcomes, TTF was longer in the group with <3 liver metastases and in groups other than the very low hormone sensitivity group, regardless of the treatment line of EVE. Conclusions: Low hormone sensitivity and ⩾3 liver metastases were important prognostic factors for the efficacy of EVE. EVE may be less effective in patients with AMBC with these factors, and as such, chemotherapy should be administered instead.
Hepatotoxicities Induced by Neoadjuvant Chemotherapy in Colorectal Cancer Liver Metastases: Distinguishing the True From the False
Authors: Desjardin Marie , Bonhomme Benjamin , Le Bail Brigitte , Evrard Serge , Brouste Véronique , Desolneux Gregoire , Fonck Marianne , Bécouarn Yves , Béchade Dominique 
Published: January 2019

Background: Pre-operative chemotherapy for colorectal liver metastasis (CRLM) is thought to be the cause of hepatotoxicity of non-tumoural parenchyma. Studies on hepatotoxicity are contradictory. We investigated the impact of a single-line pre-operative chemotherapy on non-tumoural liver analysed by an expert hepatico-pancreatico-biliary pathologist, and the consequences on surgical outcomes. Patients and methods: Patients operated for CRLM, after a pure first-line pre-operative chemotherapy, were retrospectively included. Two comparative histopathological analyses were performed for vascular toxicity and steatohepatitis. Results: Between 2003 and 2015, 147 patients were included. Chemotherapy was based on oxaliplatin (40.1%), irinotecan (55.8%), or both (4.1%). The expert pathologist described 38.8% of vascular lesions including dilation, nodular regeneration, and peliosis. In multivariate analysis, vascular lesions correlated to male sex ( P = .01), pre-operative platelets <150 g/L ( P = .04), and aspartate aminotransferase to platelet ratio index (APRI) score >0.36 ( P = .02). Steatohepatitis was observed in 15 patients (10.2%), more frequently after irinotecan (14.8% vs 3.4%, P = .01; odds ratio [OR] = 7.3; 95% confidence interval [CI] = [1.5-34.7]), and for patients with body mass index (BMI) >25 kg/m2 ( P = .004; OR = 10.0; 95% CI = [2.1-47.5]). A total of 29 patients (19.7%) developed major complications with 2 risk factors: portal vein obstruction (PVO) and septic surgery. Reproducibility assessment of steatohepatitis and dilated lesions by 2 pathologists showed moderate agreement (Kappa score 0.53 and 0.54, respectively). Conclusions: There is a probable association between non-alcoholic steatohepatitis (NASH) and irinotecan. Oxaliplatin seems to lead to higher vascular lesions. Except in the presence of pre-existent comorbidities, liver toxicities should not restrain the use of pre-operative chemotherapy prior to parenchymal-sparing surgery.
Long-term follow-up of a phase 3 clinical trial of inolimomab for the treatment of primary steroid refractory aGVHD
Authors: Socié Gérard , Milpied Noel , Yakoub-Agha Ibrahim , Bay Jacques-Olivier , Fürst Sabine , Bilger Karin , Suarez Felipe , Michallet Mauricette , Lewalle Philippe , Liens David , Mathis Catherine , Guemas Eric , Vernant Jean-Paul 
Published: January 2019

Abstract
The treatment of steroid refractory acute graft-versus-host disease has been a significant clinical challenge. There have been relatively few randomized clinical trials comparing different treatment options. One such approach was the use of inolimomab (an anti-CD25 monoclonal antibody that blocks interleukin-2 signaling) that was compared to antithymocyte globulin in the INO107 phase 3 trial. Socié and colleagues report on the long-term follow-up of patients treated on this trial.
Teaching Re-use Strategies for Modernist Buildings.
Authors: De Vos Els , Storgaard Eva 
Published: January 2019

The joint European+ project Re-use of Modernist Buildings (RMB) started its activities in 2016. It is an educational collaboration between different European universities and organisations. The main objectives of this initiative is on the one hand to enhance student and staff mobility through a shared educational programme on master degree level; on the other hand it is to develop transformation strategies for modernist buildings, mainly from the post-war period. RMB wants to develop an educational approach to this specific architectural heritage based on common definitions, approaches and methodologies. It takes its point of departure in existing research, educational practices and reference projects in the partner countries. This paper discusses the need for appropriate approaches to modernist buildings, definitions of re-use strategies and the position of RMB – as well as how the project’s educational programme is conceived and structured. Additional a more detailed description of the concept and the making of a so-called Case Study Handbook of Modernist Buildings follows, illuminating its asset as an important research and design tool.
Modern Architecture as Inextensible
Authors: Yaneva Albena 
Published: January 2019

I will begin with this provocative, and quite unusual image, of an iconic building that we all know – the Eiffel Tower. Some of you might have heard about the media debates surrounding the “new design for the restructuring of the public spaces of the Eiffel Tower” announced by the French architect David Serero in March 2008. He suggested doubling the size of the tower’s highest observational platform. The architect claimed that “his firm’s proposal was accepted after an open call, and that the structure is expected to be assembled for the 120th anniversary of the tower construction.” But shortly after that, the government-contracted firm that manages the tower – la Société d’Exploitation de la Tour Eiffel – stated that the claims of the architect are a “hoax.” The communication chief denied that there was ever any call for architects regarding plans to redevelop the top of the monument and that Serero Architects never presented themselves as candidates for such a competition. The media outlets that ran with the story included: The Guardian, The New York Times, Architect, Bustler, The Daily Telegraph and Belfast Telegraph.
Instrumental diagnosis of coxitis in ankylosing spondylitis in real clinical practice
Authors: Agafonova E. M. , Dubinina T. V. , Demina A. B. , Smirnov A. V. , Erdes Sh. F. 
Published: January 2019

Coxitis is one of the most common extra-axial manifestations of ankylosing spondylitis (AS). Most Russian studies consider hip joint (HJ) involvement in AS patients as a major factor of poor prognosis in this disease. All detected hip joint changes are characterized by one term «coxitis». Until recently, there has been no clarity on inflammation of which structures of HJ leads to its destruction. This problem can be solved by prospective studies. A start was made by the V.A. Nasonova Research Institute of Rheumatology on the study of the evolution of coxitis in AS in 2013. This communication is devoted to the results initially identified by various imaging techniques for detecting HJ changes.Objective:to study the characteristics of HJ injury in AS, which have been detected by different imaging techniques.Subjects and methods.The investigation enrolled 125 AS patients, including 84 men (a male/female ratio of 2:1). The mean age of the patients was 31.4±9.1 years; the mean age at disease onset – 24.6±4.4 years; the median duration of AS at the time of examination – 96 (12–444) months. The HLA-B27 antigen was present in the majority of patients (94%). AS activity defined by ASDAS-CRP and BASDAI was high; BASFI scores averaged 3.4±2.1. All the patients underwent the following instrumental examinations: plain pelvis radiography, HJ ultrasound and magnetic resonance imaging (MRI).Results and discussion.The clinical, ultrasound, and MRI signs of coxitis were found in 82, 75, and 88% of cases, respectively; coxitis was radiologically confirmed only in 50% of patients. This disease was diagnosed by several techniques in the vast majority of cases. The diagnosis of coxitis was based only on clinical signs in only three (2%) patients. In approximately every sixth (16%) patients with AS, who had clinical signs of coxitis, the latter was verified only by one of the instrumental techniques (ultrasonography, radiography, or MRI). Our findings demonstrated that more than half of patients had high coxitis activity, and more prolonged coxitis was responsible for higher X-ray HJ changes and functional limitations.Conclusion.Our study has showed that the instrumental techniques used to diagnose coxitis are not equivalent in evaluating HJ injury. To decide which of them is more effective in screening and predicting the course of coxitis, there is a need for further prospective investigations.
Prasangka dan Konstruksi Seksualitas LGBT dalam Majalah Al-Wa’ie Online
Authors: Syaifullah Syaifullah 
Published: January 2019

Law No. 39, 1999 Chapter 3 guarantees people’s protection of human rights. However, in fact, discriminations still exist in social life. LGBT is one of the objects of discrimination by many parties. Media is an example. The presence of media influences people’s preconception. This study investigates al-Wa’ie’, an online magazine, focusing on it’s prejudice and sexuality construction of LGBT. This study is of literature review with discourse analysis method. The data is analyzed using Baron and Byrne’s theory of prejudice and theory of sexuality construction. The results of the study indicated that there were prejudices on online al-Wa’ie’ Magazine of LGBT, that consisted of: first, cogni- tive component, i.e. a stereotyping of LGBT as criminals, perverted-minded, and harmed the value of humanity; second, affective component, i.e. the use of negative words as well as the urge to exterminate LGBT; third, conative component, i.e. hostility and discrimination toward LGBT. The sexuality construction on online al-Wa’ie’ Magazine.
A strong stability condition on minimal submanifolds and its implications
Authors: Tsai Chung-Jun , Wang Mu-Tao 
Published: January 2019

AbstractWe identify a strong stability condition on minimal submanifolds that implies uniqueness and dynamical stability properties. In particular, we prove a uniqueness theorem and a𝒞1{\mathcal{C}^{1}}dynamical stability theorem of the mean curvature flow for minimal submanifolds that satisfy this condition. The latter theorem states that the mean curvature flow of any other submanifold in a𝒞1{\mathcal{C}^{1}}neighborhood of such a minimal submanifold exists for all time, and converges exponentially to the minimal one. This extends our previous uniqueness and stability theorem [24] which applies only to calibrated submanifolds of special holonomy ambient manifolds.
Correlates of resistin and retinol-binding protein 4 in metabolic syndrome patients with and without prediabetes
Authors: Horan Abeer Abu , Albsoul-Younes Abla , Kasabri Violet , Suyagh Maysa , Halaseh Lana , AlAlawi Sundus 
Published: January 2019

Abstract

Background
Resistin and retinol-binding protein 4 (RBP4) can work in an intricate in metabolic syndrome (MetS) and prediabetes (PreDM) molecular crosstalk.

Materials and methods
Resistin and RBP4 were evaluated using colorimetric enzyme-linked immunosorbent assays (ELISAs) in 29 normoglycemic MetS, 30 newly diagnosed drug naïve MetS-preDM patients and 29 lean and normoglycemic controls.

Results
In this cross-sectional design; the gradual increase in resistin levels (ng/mL), though not ascribed any statistically marked variation, was appreciable in both normoglycemic and preDM MetS groups vs. controls. RBP4 mean circulating levels (ng/mL) in both MetS groups (non-diabetic and preDM) invariably lacked discrepancy vs. controls. Except for fasting plasma glucose (FPG) and A1C; no further intergroup discrepancy could be identified between MetS arms. Adiposity indices: body mass index (BMI), body adiposity index (BAI) and lipid accumulation product (LAP) (but not conicity index) were substantially higher in both MetS (non- and preDM) groups vs. those of controls. Likewise, the atherogenicity index of plasma [but not non-high-density lipoprotein-cholesterol (nonHDL-C)/HDL-C ratio, or triglyceride (TG)/HDL-C ratio] or any of the hematological indices [red cell distribution width (RDW-CV %), monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR) and platelet (PLT) to lymphocyte ratios (PLR)] had any marked variations as compared to controls. Low-density lipoprotein-cholesterol (LDL-C)/HDL-C ratio,visceral adiposity index, and waist circumference (WC)/hip circumference (HC) ratio were noticeably greater in MetS-preDM vs. normoglycemic MetS recruits. Neither biomarker could relate to each other, or any of the atherogenecity indices in 59 MetS participants (non- and preDM). Unlike RBP4; resistin associated proportionally with each of HC, BAI, MLR and NLR.

Conclusions
Both biomarkers can be putative indicator/surrogate prognostic tools for the prediction/prevention and pharmacotherapy of MetS anomalies.