bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual dimorphism in the control of skeletal muscle interstitial Po2 of heart failure rats: effects of dietary nitrate supplementation
Authors: Craig Jesse C. , Colburn Trenton D. , Hirai Daniel M. , Musch Timothy I. , Poole David C. 
Published: March 2019

Sex differences in the mechanisms underlying cardiovascular pathophysiology of O2 transport in heart failure (HF) remain to be explored. In HF, nitric oxide (NO) bioavailability is reduced and contributes to deficits in O2 delivery-to-utilization matching. Females may rely more on NO for cardiovascular control and as such experience greater decrements in HF. We tested the hypotheses that moderate HF induced by myocardial infarction would attenuate the skeletal muscle interstitial Po2 response to contractions (Po2is; determined by O2 delivery-to-utilization matching) compared with healthy controls and females would express greater dysfunction than male counterparts. Furthermore, we hypothesized that 5 days of dietary nitrate supplementation (Nitrate; 1 mmol·kg−1·day−1) would raise Po2is in HF rats. Forty-two Sprague-Dawley rats were randomly assigned to healthy, HF, or HF + Nitrate groups (each n = 14; 7 female/7 male). Spinotrapezius Po2is was measured via phosphorescence quenching during electrically induced twitch contractions (180 s; 1 Hz). HF reduced resting Po2is for both sexes compared with healthy controls ( P < 0.01), and females were lower than males (14 ± 1 vs. 17 ± 2 mmHg) ( P < 0.05). In HF both sexes expressed reduced Po2is amplitudes following the onset of muscle contractions compared with healthy controls (female: −41 ± 7%, male: −26 ± 12%) ( P < 0.01). In HF rats, Nitrate elevated resting Po2is to values not different from healthy rats and removed the sex difference. Female HF + Nitrate rats expressed greater resting Po2is and amplitudes compared with female HF ( P < 0.05). In this model of moderate HF, O2 delivery-to-utilization matching in the interstitial space is diminished in a sex-specific manner and dietary nitrate supplementation may serve to offset this reduction in HF rats with greater effects in females. NEW & NOTEWORTHY Interstitial Po2 (Po2is; indicative of O2 delivery-to-utilization matching) determines, in part, O2 flux into skeletal muscle. We show that heart failure (HF) reduces Po2is at rest and during skeletal muscle contractions in rats and this negative effect is amplified for females. However, elevating NO bioavailability with dietary nitrate supplementation increases resting Po2is and alters the dynamic response with greater efficacy in female HF rats, particularly at rest and following the onset of muscle contractions.
Menstrual cycle-associated modulations in neuromuscular function and fatigability of the knee extensors in eumenorrheic women
Authors: Ansdell Paul , Brownstein Callum G. , Škarabot Jakob , Hicks Kirsty M. , Simoes Davina C. M. , Thomas Kevin , Howatson Glyn , Hunter Sandra K. , Goodall Stuart 
Published: March 2019

Sex hormone concentrations of eumenorrheic women typically fluctuate across the menstrual cycle and can affect neural function such that estrogen has neuroexcitatory effects, and progesterone induces inhibition. However, the effects of these changes on corticospinal and intracortical circuitry and the motor performance of the knee extensors are unknown. The present two-part investigation aimed to 1) determine the measurement error of an exercise task, transcranial magnetic stimulation (TMS)-, and motor nerve stimulation (MNS)-derived responses in women ingesting a monophasic oral contraceptive pill (hormonally-constant) and 2) investigate whether these measures were modulated by menstrual cycle phase (MCP), by examining them before and after an intermittent isometric fatiguing task (60% of maximal voluntary contraction, MVC) with the knee extensors until task failure in eumenorrheic women on days 2, 14, and 21 of the menstrual cycle. The repeatability of neuromuscular measures at baseline and fatigability ranged between moderate and excellent in women taking the oral contraceptive pill. MVC was not affected by MCP ( P = 0.790). Voluntary activation (MNS and TMS) peaked on day 14 ( P = 0.007 and 0.008, respectively). Whereas corticospinal excitability was unchanged, short-interval intracortical inhibition was greatest on day 21 compared with days 14 and 2 ( P < 0.001). Additionally, time to task failure was longer on day 21 than on both days 14 and 2 (24 and 36%, respectively, P = 0.030). The observed changes were larger than the associated measurement errors. These data demonstrate that neuromuscular function and fatigability of the knee extensors vary across the menstrual cycle and may influence exercise performance involving locomotor muscles. NEW & NOTEWORTHY The present two-part study first demonstrated the repeatability of transcranial magnetic stimulation- and electrical motor nerve stimulation-evoked variables in a hormonally constant female population. Subsequently, it was demonstrated that the eumenorrheic menstrual cycle affects neuromuscular function. Changing concentrations of neuroactive hormones corresponded to greater voluntary activation on day 14, greater intracortical inhibition on day 21, and lowest fatigability on day 21. These alterations of knee extensor neuromuscular function have implications for locomotor activities.
A Moist Conceptual Model for the Boundary Layer Structure and Radiatively Driven Shallow Circulations in the Trades
Authors: Naumann Ann Kristin , Stevens Bjorn , Hohenegger Cathy 
Published: March 2019

AbstractA conceptual model is developed to analyze how radiative cooling and the effect of moisture and shallow convection modify the boundary layer (BL) structure and the strength of mesoscale shallow circulations. The moist BL allows for a convective mass flux to modify the BL mass balance, which enhances inversion entrainment compared to a dry case and acts as a moisture valve to the BL. The convective mass flux is found to be insensitive to the applied radiative cooling and in the absence of heterogeneities cloud-free conditions exist only for unusual large-scale forcings. The model is able to explain the moderate range of BL heights and humidities observed in the trades. In a two-column setup, differential radiative BL cooling causes a pressure difference, which drives a BL flow from the cold and moist column to the warm and dry column and couples them dynamically. The small inversion buoyancy jump of the moist BL yields a stronger BL flow of 4 m s−1 instead of 1 m s−1 in the dry case. For typical conditions of the subsidence-dominated tropical oceans, a radiatively driven shallow circulation is stronger than one driven by sea surface temperature (SST) gradients. While the strength of the SST-driven circulation decreases with decreasing SST difference, the radiatively driven circulation is insensitive to the radiative BL cooling difference. In both cases, convection is suppressed in the descending branch of the shallow circulation and enhanced in the ascending branch, resembling patterns of organized shallow convection.
Turbulent Collapse and Recovery in the Stable Boundary Layer Using an Idealized Model of Pressure-Driven Flow with a Surface Energy Budget
Authors: Holdsworth Amber M. , Monahan Adam H. 
Published: March 2019

AbstractThe evolution of the stable boundary layer is simulated using an idealized single-column model of pressure-driven flow coupled to a surface energy budget. Several commonly used parameterizations of turbulence are examined. The agreement between the simulated wind and temperature profiles and tower observations from the Cabauw tower is generally good given the simplicity of the model. The collapse and recovery of turbulence is explored in the presence of a large-scale pressure gradient, but excluding transient submesoscale atmospheric forcings such as internal waves and density-driven currents. The sensitivity tests presented here clarify the role of both rotation and the surface energy budget in the collapse and recovery of turbulence for the pressure-driven dry stable boundary layer (SBL). Conditions of stability are affected strongly by the geostrophic winds, the cloud cover, and the thermal conductivity of the surface. Inertial oscillations and the subsurface temperature have a weaker influence. Particularly noteworthy is the relationship between SBL regime and the relative importance of the terms in the surface energy budget.
Lyapunov Exponents and Temperature Transitions in a Warming Australia
Authors: Gilmore Stephen 
Published: March 2019

AbstractMultiple potential tipping points in the Earth system that involve alternative states have been identified that are susceptible to anthropogenic forcing. Past events—from millions of years ago to within the last century—have manifest as abrupt changes in climatic indicators such as the temperature record. Recent unprecedented heat waves in Australia, their associated devastation, and the considerations above provide motivation to ask whether the Australian daily maximum temperature record has been subject to such abrupt changes. Using a new diagnostic tool—the Lyapunov plot—here it is shown that multiple temperature transitions have occurred with respect to the maximum daily temperature record in widely separated locations in Australia over the last 150 years. All maximum Lyapunov exponents are positive in sign, indicating that the transitions are chaos-to-chaos transitions, and that the different climate modes identified are likely to be manifestations of distinct chaotic attractors. Many of these events occur simultaneously with transitions or extremes in the major natural cycles affecting Australia’s climate, but this observation is not universal. It is known that chaos-to-chaos transitions can result in changes in the value(s) of the state variable(s) that can range from subtle to severe. Although the identified transitions are not catastrophic, this observation does not rule out the possibility of severe, unprecedented, and discontinuous increases in average daily maximum temperatures occurring in Australia at any time within the next few decades.
Reconciling Emotion and Rational Choice: Negativistic Auto Theft, Consequence Irrelevance, and the Seduction of Destruction
Authors: Jacobs Bruce A. , Cherbonneau Michael 
Published: March 2019

Objectives: We explore negativism in the context of auto theft and examine its broader phenomenological significance for Rational Choice Theory. Methods: Data were drawn from qualitative, in-depth interviews with 35 active auto thieves operating out of a large Midwestern U.S. city. Results: Negativistic offending is malicious, spiteful, and/or destructive conduct whose purpose is typically more hedonic (i.e., short-term gratification) than instrumental (i.e., resource-generating) or normative (i.e., moralistic). It is made possible by the notion of ownership without responsibility: Offenders controlled a vehicle that was not theirs, promoting consequence irrelevance which in turn unleashed reckless conduct. Conclusions: Consequence irrelevance clarifies negativism’s logic and permits linkage between affect-based and rational choice decision-making models.
Should we include monitors to improve assessment of awareness and pain in unconscious palliatively sedated patients? A case report
Authors: Six Stefaan , Laureys Steven , Poelaert Jan , Bilsen Johan , Theuns Peter , Musch Liza , Deschepper Reginald 
Published: March 2019

Background: Awareness and pain during palliative sedation is typically assessed by observational scales, but the use of such scales has been put into question. Case presentation: A woman in her mid-80s was admitted to a palliative care unit, presenting with chronic lymphatic leukemia, depression, and a cerebrovascular accident, with right-sided hemiplegia and aphasia. The patient was unable to eat and was suffering from nausea and vomiting. Before admission, the patient had expressed her desire to discontinue treatment on several occasions. Case management: The decision was made to initiate palliative sedation. The patient consented to take part in a study to assess level of comfort and pain using two monitoring devices (NeuroSense monitor and Analgesia Nociception Index monitor). Case outcome: The patient died 90 h after initiation of palliative sedation. Titration of the medication was challenging and sedation was not deep enough during the first 2 days. Thirteen assessments made with the Ramsay Sedation Scale showed that the patient was considered to be in a deep sleep, while in fact the NeuroSense monitor indicated otherwise. Conclusion: This case demonstrates the feasibility and potential advantages of using monitoring devices to objectify assessments of pain and discomfort in palliatively sedated patients.
Branch atheromatous disease has a stronger association with late-onset epileptic seizures than lacunar infarction in Japanese patients
Authors: Obata Kaoru , Kinoshita Masako , Sato Kazuaki , Chin Masaki , Yamagata Sen , Ikeda Akio , Shindo Katsuro 
Published: March 2019

Objective To evaluate the relationship between late-onset epileptic seizures and non-cortical infarction (namely, lacunar infarction and branch atheromatous disease [BAD]) in Japanese patients. Methods We reviewed the medical records and brain magnetic resonance imaging findings of all patients with ischemic stroke admitted to the Departments of Neurology, Neurosurgery, and Stroke Unit at Kurashiki Central Hospital from 1 January 2011 to 31 December 2012. Patients with lacunar infarction and BAD were enrolled; those with cortical and brain stem ischemic lesions were excluded. We analyzed the clinical features of patients who developed late-onset epileptic seizures after cerebral infarction. Results Eighty-five patients with lacunar infarction and 99 patients with BAD were enrolled. Four patients with BAD subsequently developed epileptic seizures (2.2% of total patients, 4.0% of patients with BAD), whereas no patients with lacunar infarction developed epileptic seizures. All patients with epileptic seizures had infarction involving the basal ganglia or thalamus. Three of them had multiple cerebral microbleeds, and two had dementia. Conclusions Patients with BAD, but not with lacunar infarction, might have a higher risk of developing epileptic seizures than the general population. Non-cortical infarctions with involvement of the basal ganglia or thalamus may increase the risk of subsequent late-onset epileptic seizures.
Leucocyte-Rich Platelet-Rich Plasma Treatment of Gluteus Medius and Minimus Tendinopathy: A Double-Blind Randomized Controlled Trial With 2-Year Follow-up
Authors: Fitzpatrick Jane , Bulsara Max K. , O’Donnell John , Zheng Ming Hao 
Published: March 2019

Background: A previously published trial showed that patients with chronic gluteal tendinopathy achieved greater clinical improvement at 12 weeks when treated with a single platelet-rich plasma (PRP) injection than those treated with a single corticosteroid injection (CSI). Purpose: This follow-up study was conducted to determine whether there would be a sustained long-term difference in the modified Harris Hip Score (mHHS) at 2 years for a leucocyte-rich PRP (LR-PRP) injection in the treatment of chronic gluteal tendinopathy. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: This trial included 80 patients randomized 1:1 to receive LR-PRP or CSI intratendinously under ultrasound guidance. Patients had a mean age of 60 years, a 9:1 ratio of women to men, a mean body mass index of 27, and a mean length of symptoms >15 months. No patients had full-thickness tears of the gluteal tendons. An open-labeled extension allowed patients to receive crossover treatment after 3 months. The main outcome measure was the mHHS. Results: The mean mHHS improved significantly at 12 weeks in the PRP group (74.05; SD, 13.92) as compared with the CSI group (67.13; SD, 16.04) ( P = .048). At 24 weeks, the LR-PRP group (77.60; SD, 11.88) improved further than the CSI group (65.72; SD, 15.28; P = .0003). Twenty-seven patients were deemed to have failed the CSI treatment at 16 to 24 weeks, with an exit score of 59.22 (SD, 11.54), and then had treatment with LR-PRP. The crossover group improved with the LR-PRP: from 59.22 (SD, 11.22) at baseline to 75.55 (SD, 16.05) at 12 weeks, 77.69 (SD, 15.30) at 24 weeks, and 77.53 (SD, 14.54) at 104 weeks. The LR-PRP group retained 38 of 39 patients to 52 weeks and continued to improve. Their baseline scores of 53.77 (SD, 12.08) improved to 82.59 (SD, 9.71) at 104 weeks ( P < .0001). Conclusion: Among patients with chronic gluteal tendinopathy and a length of symptoms >15 months, a single intratendinous LR-PRP injection performed under ultrasound guidance results in greater improvement in pain and function than a single CSI. The improvement after LR-PRP injection is sustained at 2 years, whereas the improvement from a CSI is maximal at 6 weeks and not maintained beyond 24 weeks. Registration: ACTRN12613000677707 (Australian New Zealand Clinical Trials identifier).
Characteristics and Outcomes of Patients With and Without Type 2 Diabetes Mellitus and Pulmonary Sepsis
Authors: Sathananthan Matheni , Sathananthan Airani , Jeganathan Niranjan 
Published: March 2019

Purpose: To date, studies have provided conflicting results regarding the impact of type 2 diabetes mellitus (DM) on sepsis-related outcomes. Our objective is to understand the impact of type 2 DM in bacterial pneumonia and sepsis-related intensive care unit (ICU) outcomes. Methods: Retrospective study using Multiparameter Intelligent Monitoring in Intensive Care III database. We included 1698 unique patients admitted with sepsis secondary to bacterial pneumonia to the ICU within the time period of 2001 to 2012. Results: The type 2 DM group had an increased incidence of acute kidney injury (67.9% vs 58.1%, P < .01) and need for dialysis compared to the non-DM group. There was no difference in mortality, microbiology, other organ failure, or hospital length of stay between the type 2 DM and non-DM group. Lower admission blood glucose was associated with increased mortality in patients with type 2 DM (49% at ≤120 mg/dL, 35.1% at 121-180 mg/dL, and 32.1% at >180 mg/dL) but not in non-DM patients. Conversely, higher mean glucose during the hospital stay was associated with increased mortality in non-DM patients (24.7% at ≤120 mg/dL, 45.1% at 121-180 mg/dL, and 73.0% at >180 mg/dL) but not in patients with type 2 DM. Conclusions: Our findings demonstrated that type 2 DM does not increase the overall mortality. Our findings of increased mortality in both type 2 DM patients with lower admission glucose, and non-DM patients with higher mean glucose during the hospital stay needs to be further evaluated. Future studies in regards to this could lead to personalized glucose treatment goals for patients.
Short-term contracts and their effect on wages in Indian regular wage employment
Authors: Menon Rahul 
Published: March 2019

The increase in regular wage employment in the Indian economy between 2004–2005 and 2011–2012 was accompanied by a significant deterioration in job security; more workers found themselves on short-term and insecure contracts – a continuing trend. Insecurity of tenure results in a significant wage penalty for short-term workers, compared with those with longer term contracts. This article estimates the negative effect of short-term contracts on the wages of Indian regular wage workers all along the income distribution – unlike earlier studies – using the method of unconditional quantile regressions on data from the 68th round and the 61st round of the National Sample Survey Organisation on Employment covering the period 2004–2005 and 2011–2012. It finds that the wage penalty due to short-term contracts is higher for high-wage workers than for low-wage workers, with the maximum impact felt by median wage workers, and has increased for higher paid workers from 2004–2005 to 2011–2012. The spread of informal employment arrangements within India’s formal labour markets has resulted in an increasingly unequal distribution of workers’ access to the benefits of growth, reflecting a shift in power in favour of capital. These findings, specific to a developing economy like India, stand in contrast with studies in European countries, where high-wage workers do not face as much of a penalty for short-term contract work as low-wage workers.JEL Codes: J31, J41
Developing a Task Switching Training Game for Children With a Rare Genetic Syndrome Linked to Intellectual Disability
Authors: Robb Nigel , Waller Annalu , Woodcock Kate A. 
Published: March 2019

Background. The ability to rapidly switch between tasks is important in a variety of contexts. Training in task switching may be particularly valuable for children with intellectual disability (ID), specifically ID linked to genetic syndromes such as Prader-Willi syndrome (PWS). We have developed a cognitive training game for children with PWS and performed a pilot evaluation of the programme to inform future game development. Here, we describe and critically reflect on the development and pilot evaluation process. Methods. Several novel aspects of our approach are highlighted in this paper, including the involvement (in various roles) of children with a rare genetic syndrome (PWS) in the development and evaluation of the software (participatory design) and the development of a matched control, or placebo version of the game for use in the pilot evaluation. Results. Children with PWS were capable of contributing to the design and development of a cognitive training game in various roles. In the subsequent pilot evaluation, playing the active version of the game was associated with greater improvement in task switching performance than playing the matched control (placebo) version of the game. However, attrition was an issue during both the design phase and the pilot evaluation. Conclusions. The lessons learned from our work have relevance in a wide range of contexts, such as the development of future cognitive training games; the evaluation of serious games in general; and the involvement of end-users with cognitive disabilities and/or rare syndromes in the design and development of software.
Genomic and Immunologic Drivers of Very Early-Onset Inflammatory Bowel Disease
Authors: Conrad Maire A , Kelsen Judith R 
Published: March 2019

Purpose of Review Inflammatory bowel disease (IBD) is a multifactorial disease caused by dysregulated immune responses to commensal or pathogenic intestinal microbes, resulting in chronic intestinal inflammation. However, a subset of patients with IBD diagnosed <6 years of age, known as very early-onset (VEO)-IBD, can be phenotypically and genetically distinct from older onset IBD. We aim to review the clinical presentation of children with VEO-IBD and recent discoveries that point to the underlying genomic and immunologic drivers of disease, and the significant impact on our therapeutic decisions. Recent Findings VEO-IBD is increasing in incidence and is associated with more severe disease, aggressive progression, and poor response to most conventional therapies. This article will review some of the genetic findings in this population and the subsequent impact on therapy, with targeted approaches. Summary Children with VEO-IBD may present with a different phenotype and more severe disease than older children and adults. An integrated approach combining genetics, immunology, and traditional IBD evaluations can lead to the identification of causal defects that directly impact management. These strategies can also be employed in older onset refractory IBD.