bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integration of Health Questionnaire Systems to Facilitate Supportive Care Services for Patients at an Academic Breast Care Center
Authors: Wong Emily C. , Kaplan Celia P. , Dreher Nickolas , Hwang Jimmy , van’t Veer Laura , Melisko Michelle E. 
Published: October 2018

Purpose This study evaluated the use of an electronic Health Questionnaire System (HQS) within the University of California San Francisco Breast Care Center as a screening and triage tool to proactively recognize patients’ supportive care needs during new patient consultations and identify demographic characteristics associated with referrals to three supportive care services. Patients and Methods A total of 428 patients with and without breast cancer between the ages of 18 and 84 years completed HQS intake forms before appointments at the University of California San Francisco Breast Care Center between November 2014 and May 2015 and agreed to participate in this study. Patient HQS responses triggered referrals to supportive care services, and a review of electronic health records was conducted to determine the outcomes of these referrals. Results A total of 242 patients (56.5%) met criteria for at least one supportive care referral. Women with invasive breast cancer or ductal carcinoma in situ met criteria for supportive services more frequently than women without breast cancer diagnoses (76.9% v 23.8%; P < .001) and were most likely to receive referrals for genetic counseling (67.0%), psychological services (32.2%), and social services (12.1%). Multivariable logistic regression analysis showed that being married was associated with fewer referrals to social work (OR, 0.42; 95% CI, 0.21 to 0.81) and that those between 45 and 54 years of age were less likely to receive referrals to genetic counseling than those ≥ 55 years of age (OR, 0.41; 95% CI, 0.23 to 0.73). Among all referrals (n = 369), 26.8% resulted in completed appointments. Conclusion Using an automated intake form is an efficient way to identify and triage individuals in need of supportive care services and can provide insight into the populations with supportive care needs for targeted outreach.
Questioning the Value of Fluorodeoxyglucose Positron Emission Tomography for Residual Lesions After Chemotherapy for Metastatic Seminoma: Results of an International Global Germ Cell Cancer Group Registry
Authors: Cathomas Richard , Klingbiel Dirk , Bernard Brandon , Lorch Anja , Garcia del Muro Xavier , Morelli Franco , De Giorgi Ugo , Fedyanin Mikhail , Oing Christoph , Haugnes Hege Sagstuen , Hentrich Marcus , Fankhauser Christian , Gillessen Silke , Beyer Jörg 
Published: October 2018

Purpose Residual lesions after chemotherapy are frequent in metastatic seminoma. Watchful waiting is recommended for lesions < 3 cm as well as for fluorodeoxyglucose (FDG) positron emission tomography (PET)–negative lesions ≥ 3 cm. Information on the optimal management of PET-positive residual lesions ≥ 3 cm is lacking. Patients and Methods We retrospectively identified 90 patients with metastatic seminoma with PET-positive residual lesions after chemotherapy. Patients with elevated α-fetoprotein or nonseminomatous histology were excluded. We analyzed the post-PET management and its impact on relapse and survival and calculated the positive predictive value (PPV) for PET. Results Median follow-up time was 29 months (interquartile range [IQR], 10 to 62 months). Median diameter of the largest residual mass was 4.9 cm (range, 1.1 to 14 cm), with masses located in the retroperitoneum (77%), pelvis (16%), mediastinum (17%), and/or lung (3%). Median time from the last day of chemotherapy to PET was 6.9 weeks (IQR, 4.4 to 9.9 weeks). Post-PET management included repeated imaging in 51 patients (57%), resection in 26 patients (29%), biopsy in nine patients (10%) and radiotherapy in four patients (4%). Histology of the resected specimen was necrosis in 21 patients (81%) and vital seminoma in five patients (19%). No biopsy revealed vital seminoma. Relapse or progression occurred in 15 patients (17%) after a median of 3.7 months (IQR, 2.5 to 4.9 months) and was found in 11 (22%) of 51 patients on repeated imaging, in two (8%) of 26 patients after resection, and in two (22%) of nine patients after biopsy. All but one patient who experienced relapse were successfully treated with salvage therapy. The PPV for FDG-PET was 23%. Conclusion FDG-PET has a low PPV for vital tumor in residual lesions after chemotherapy in patients with metastatic seminoma. This cautions against clinical decisions based on PET positivity alone.
What Can Be Done to Improve Research Biopsy Quality in Oncology Clinical Trials?
Authors: Ferry-Galow Katherine V. , Datta Vivekananda , Makhlouf Hala R. , Wright John , Wood Bradford J. , Levy Elliot , Pisano Etta D. , Tam Alda L. , Lee Susanna I. , Mahmood Umar , Rubinstein Lawrence V. , Doroshow James H. , Chen Alice P. 
Published: October 2018

Purpose: Research biopsy specimens collected in clinical trials often present requirements beyond those of tumor biopsy specimens collected for diagnostic purposes. Research biopsies underpin hypothesis-driven drug development, pharmacodynamic assessment of molecularly targeted anticancer agents, and, increasingly, genomic assessment for precision medicine; insufficient biopsy specimen quality or quantity therefore compromises the scientific value of a study and the resources devoted to it, as well as each patient’s contribution to and potential benefit from a clinical trial. Methods: To improve research biopsy specimen quality, we consulted with other translational oncology teams and reviewed current best practices. Results: Among the recommendations were improving communication between oncologists and interventional radiologists, providing feedback on specimen sufficiency, increasing academic recognition and financial support for the time investment required by radiologists to collect and preserve research biopsy specimens, and improving real-time assessment of tissue quality. Conclusion: Implementing these recommendations at the National Cancer Institute’s Developmental Therapeutics Clinic has demonstrably improved the quality of biopsy specimens collected; more widespread dissemination of these recommendations beyond large clinical cancer centers is possible and will be of value to the community in improving clinical research and, ultimately, patient care.
The RECK tumor-suppressor protein binds and stabilizes ADAMTS10
Authors: Matsuzaki Tomoko , Kitayama Hitoshi , Omura Akira , Nishimoto Emi , Alexander David B. , Noda Makoto 
Published: October 2018

ABSTRACT
The tumor suppressor protein RECK has been implicated in the regulation of matrix metalloproteinases (MMPs), NOTCH-signaling and WNT7-signaling. It remains unclear, however, how broad the spectrum of RECK targets extends. To find novel RECK binding partners, we took the unbiased approach of yeast two-hybrid screening. This approach detected ADAMTS10 as a RECK-interactor. ADAMTS10 has been characterized as a metalloproteinase involved in fibrillin-rich microfibril biogenesis, and its mutations have been implicated in the connective tissue disorder Weill-Marchesani syndrome. Experiments in vitro using recombinant proteins expressed in mammalian cells indicated that RECK indeed binds ADAMTS10 directly, that RECK protects ADAMTS10 from fragmentation following chemical activation and that ADAMTS10 interferes with the activity of RECK to inhibit MT1-MMP. In cultured cells, RECK increases the amount of ADAMTS10 associated with the cells. Hence, the present study has uncovered novel interactions between two molecules of known clinical importance, RECK and ADAMTS10.
This article has an associated First Person interview with the first author of the paper.
MODEL RESOLUSI KONFLIK KAWASAN REGISTER 45 MESUJI LAMPUNG BERBASIS HUTAN TANAMAN RAKYAT
Authors: Jaka Ferdian Komang 
Published: October 2018

Agrarian conflicts in Indonesia, one of which occurred in the region registers 45 Mesuji Lampung. The conflict in the region registers 45 result people are not getting their rights as citizens. The problem area management register 45 that conflict has reached a scale where there is a negative impact on residents who often get unilateral acts of intimidation and arrest of the security forces. The conflict that left would pose a threat to one of the parties, special nature of conflict can be widened up to the global level, there is a violence that resulted from one of the parties. The purpose of this study is to map the conflict in the region registers 45 Mesuji of Lampung and explain the model of conflict resolution in the region register 45 based on Forest Plantation. Conflict in the region register 45 involves PT. Silva Inhutani, Community Register 45, State / Government, Land Speculators, thuggery, Megoupak and Media. Model of conflict resolution that can be done through Forest Plantation. The positive side is going to cause, among others, conflict resolution, improvement in the economic sector, development environments, forming jobs, alleviate poverty and improve food security in Mesuji district. Keywords:Land Conflict; Mapping Conflict; Conflict Resolution; Mediation; Forest Plantation
MARKETING POLITIK DPP PARTAI GERINDRA PADA PEMILU LEGISLATIF 2014
Authors: Nurdiansyah Fahmi 
Published: October 2018

The purpose of this research is to know the implementation in the political marketing of Gerindra Party and some factors encouraging the party to gain a wide range of constituent voters in the legislative elections 2014. The aforementioned evidence reveals that Gerindra Party approached middle class down society and youth, on determining intended voters and this party also focusing on small society (farmer, fisherman, labour, teacher and small trader). In terms of positioning, Gerindra Party put themselves in outside of the government and acknowledge them as the party for small society. In Indonesian political constellation, it can be seen that political party has a high correlation with the power of public figure to increase popularity and electability. Gerindra Party is still introduced Prabowo Subianto as a public figure who can be used to gain a number of voters for the party.
POLITIK ETNIS FLORES TIMUR DI KABUPATEN TIMOR TENGAH UTARA PADA PEMILIHAN KEPALA DAERAH (PILKADA) 2015
Authors: Kolne Yakobus , Festianto Dian 
Published: October 2018

Penelitian ini bertujuan menggali informasi mengenai politik etnis Flores Timur (Flotim) yang berdomisili di Kabupaten Timor Tengah Utara (TTU) pada Pilkada tahun 2015 dalam perspektif politik identitas. Penentuan informan yang terdiri dari tokoh dan komunitas etnis Flotim menggunakan teknik purposive sampling dengan metode penelitian bersifat deskriptif analitis dengan menggunakan data primer dan data sekunder yang relevan dengan politik etnis Flotim. Hasil penelitian menunjukkan dinamika politik etnis Flotim membentuk enam pola relasi bersifat resiprokal. Kesimpulan penelitian ini adalah dari aspek kultural kohesifitas etnis Flotim cenderung kuat, namun dari aspek politik kehesifitas cenderung cair yang disebabkan karena faktor akulturasi budaya melalui institusi perkawinan campur dengan etnis di TTU yang terbagi dalam tiga swapraja. Hibriditas sosial budaya tersebut pada akhirya menciptakan polarisasi politik dalam komunitas etnis Flotim. Reflesi teoritis studi ini sejalan dengan konsep Castell (1997), Beerger dan Luckmann (1990) bahwa konstruksi identitas etnis Flotim di TTU ditandai oleh asal-usul bangunan identitas dan realitas politik sebagai proses kontruksi simbolik yang terus menerus berubah (situasional) terutama dalam setting Pilkada 2015.
„Projektowanie włączające” – proces projektowania nowoczesnych technologii z aktywnym udziałem adresatów rozwiązań
Authors: Marciniak-Madejska Natalia , Adamska-Kijko Magdalena 
Published: October 2018

Projekt finansowany ze środków Narodowego Centrum Badań i Rozwoju w ramach programu „Innowacje społeczne”. Doniesienie z etapu badań „System elektronicznego wspomagania samodzielności życiowej osób z niepełnosprawnością intelektualną”.
Czas wolny dzieci niepełnosprawnych intelektualnie w opinii rodziców
Authors: Kaiser Izabella 
Published: October 2018

The study aimed at diagnosing the opinions of parents of children with mild and moderate intellectual disability on the forms and significance of leisure time behaviour. The study revealed that parents, siblings, or other family members were most often partners of leisure for intellectually disabled children. All the respondents declare that they know what their children are doing in their leisure time and who they spend it with. Leisure time appears to be the area of limitless rehabilitation opportunities, and therefore it should occupy a significant position both in scientific research and (perhaps predominantly) in practical activities undertaken to help children with intellectual disability. Extensive activity of the school, family environment and special education teachers themselves is required to implement leisure time as a vital element in the process of revalidation of intellectually disabled children.
Gerontologia (geragogika) specjalna – obszar koniecznych badań i refleksji pedagogiki specjalnej. Wybrane zagadnienia
Authors: Chrzanowska Iwona 
Published: October 2018

In the text, an attempt was made to analyse selected issues related to gerontology in the relationship to people with disabilities. The context of analyses is the tendency of social ageing tendencies, observed in Poland and in the world, especially in European countries. Selected areas of reflection are combined with the conviction that there is a need for research which would fill in the gap in the field of research carried out so far, focused on the issue of the broadly defined life situation of the people with disabilities in the senior years, which is in the scientific merit of Polish special needs education (pedagogics). There is a justified fear that these individuals are more likely to experience marginalisation and exclusion in many areas of life than people of similar age in the general population.
Szczegółowa diagnoza logopedyczna dziecka z niepełnosprawnością intelektualną w stopniu umiarkowanym jako podstawa skutecznej terapii
Authors: Szurek Mateusz 
Published: October 2018

Speech and language are important in the mental and emotional development of every human being. Various speech disorders that affect the daily functioning, communication and acquiring the basic human needs can disrupt the functioning of a person in society. In the case of people with intellectual disabilities, this is an oligophasia, or the speech disorder characteristic for people with reduced intellectual ability. In this article, the author draws attention to the importance of a detailed speech diagnosis, which is the basis for the later therapeutic process. He presents in on the example of a child with moderate-degree intellectual disability, using the Afa-Skala test, while at the same time demonstrating its usefulness in diagnosing the intellectually disabled children’s language disorders. In the final part of the text the author deals with the problem of speech therapy in children with these disorders.
Radzenie sobie ze stresem rodziców dzieci z autyzmem
Authors: Dudek Mieczysław 
Published: October 2018

The appearance of a child with a disability is always a source of tremendous stress in the family. This problem is particularly evident in the case of an autistic child because of its unpredictable and untypical development. Every person during their life develops certain mechanisms to deal with difficult situations. According to Lazarus and Folkman (1987), dealing with stress mainly relies on specific intellectual activities and appropriate actions to control the requirements assessed by the person as burdensome or beyond his/her current possibilities. There are many ways of dealing with stress. The most common strategies include those focused on solving the problem (SSZ), emotional overreaction (SSE) and avoidance of stress (SSU) by engaging in substitute activities (ACZ) or seeking social interaction (CSA). It is assumed that an effective way to deal with stress consists in relating the needs and capabilities of an individual. The aim of this article was to investigate the ways of dealing with stress among 130 parents of autistic children.
Investigation of the Factors Influencing SME Failure as a Function of Its Prevention and Fast Recovery after Failure
Authors: Nikolić Nenad , Jovanović Ivan , Nikolić Đorđe , Mihajlović Ivan , Schulte Peter 
Published: October 2018

AbstractThis paper presents a conceptual framework for investigation of the factors influencing the failure of small and medium enterprises (SMEs) as well as the level of their recovery. Based on the review of literature, all the factors are classified either as individual characteristics of entrepreneurs or non-individual characteristics, that is, characteristics related to SMEs. Having in mind various factors identified by different researchers in their studies, the authors of this paper formed a basic hypothetical framework as well as a qualitative framework for evaluation of the most significant factors influencing SME failure and recovery. Accordingly, a preliminary questionnaire was designed in order to collect the attitudes of entrepreneurs regarding the impact of particular factors. The results of the survey were used for further quantitative analysis and as a base for the formation of a structural equation model for testing the proposed hypotheses.Using the structural equation model to derive results, the authors have found that all the analysed factors except the factors related to private time activities of entrepreneurs/owners of SMEs have a statistically significant influence on SME success, with external non-individual factors having the greatest influence. Furthermore, the results indicate that the level of recovery, business life cycle stage and the sector of a failed SME impact on the ranking of the factors leading to SME failure. The study points to the necessity of improving the conditions under which SMEs operate, primarily by removing the obstacles that hinder growth and development of SMEs as well as by developing the appropriate system of support for entrepreneurs. In addition, having a clear vision of the factors of failure can help SMEs to become more resistant to the adverse effects of these factors and deal with them more effectively.
A Compact Dual-Band Planar Monopole Antenna Using Fractal Rings and A Y-Shaped Feeding Transmission Line
Authors: Djafri Kahina , Challal Mouloud , Romeu Jordi 
Published: October 2018

Abstract
This paper presents a novel design approach of a compact dual-band monopole antenna with an overall size of 18.9x13x1.6mm3. The proposed antenna is composed of a fractal ring shaped patch fed by a Y-shaped transmission line on the top side of the substrate and a second fractal ring along with a U-shaped ground plane on the bottom side. The second fractal ring, identical to the radiating ring, is loaded and a rectangular slot is etched at the top side of the ground plane respectively, to achieve dual-band characteristic and improve the impedance matching. The effect of standard ground-plane (SGP) of a laptop computer is incorporated in the design; the antenna is mounted on a SGP in order to investigate its performance. The antenna covers widely the frequency bands of the WLAN 2.4 GHz (2.2–2.52 GHz) and WiMAX 3.5 GHz (3.32–4.35 GHz), and exhibits an omnidirectional radiation pattern in the H-plane and a monopole like radiation pattern in the E-plane. A good agreement between the simulated and measured results indicates that the proposed dual-band antenna design is suitable for WLAN/WiMAX applications.
Effect of biostimulants on cold resistance and productivity formation in winter rapeseed and winter wheat
Authors: Gavelienė V. , Pakalniškytė L. , Novickienė L. , Balčiauskas L. 
Published: October 2018

AbstractThe aim of the study was to investigate the effects of biostimulants on the resistance to freezing under laboratory-controlled cold conditions and on the growth, development, overwintering and productivity of winter rapeseed and winter wheat in natural field experiments. The effect of free amino acids, macroelements and microelements that contain biostimulants Ruter AA, Terra Sorb and Razormin was tested on cultivars of rapeseed, ‘Hornet H’, and winter wheat, ‘Skagen’ and ‘Kovas’, applying morphometrical methods. We found that biostimulants applied to rapeseed at BBCH 13–14 stage and to wheat at BBCH 14–15 stage under controlled cold stress conditions increased the freezing tolerance of seedlings. Biostimulants more actively increased the freezing resistance of rapeseed seedlings at –5°C compared to that of wheat seedlings. The temperature of –7°C was mortal to rape seedlings, while the resistance of wheat seedlings increased under the influence of the tested biostimulants compared to that of the control seedlings. In natural field experiments, these biostimulants produced a significant effect on plant growth in autumn, acclimation to the cold, plant overwintering, vegetation renewal and, due to this, formation of productivity elements. The effects of Razormin (200 mL/ha), Terra Sorb (2 L/ha) and Ruter AA (1 L/ha) were significantly higher on growth parameters of winter wheat compared to the productivity of winter rapeseed.
Evidence for Stabilizing Selection Driving Mutational Turnover of Short Motifs in the Eukaryotic Complementary Sex Determiner (Csd) Protein
Authors: Koch Vasco , Otte Marianne , Beye Martin 
Published: October 2018

AbstractShort linear motifs (SLiMs) can play pivotal functional roles in proteins, such as targeting proteins to specific subcellular localizations, modulating the efficiency of translation and tagging proteins for degradation. Until recently we had little knowledge about SLiM evolution. Only a few amino acids in these motifs are functionally important, making them likely to evolve ex nihilo and suggesting that they can play key roles in protein evolution. Several reports now suggest that these motifs can appear and disappear while their function in the protein is preserved, a process sometimes referred to as “turnover”. However, there has been a lack of specific experiments to determine whether independently evolved motifs do indeed have the same function, which would conclusively determine whether the process of turnover actually occurs. In this study, we experimentally detected evidence for such a mutational turnover process for nuclear localization signals (NLS) during the post-duplication divergence of the Complementary sex determiner (Csd) and Feminizer (Fem) proteins in the honeybee (Apis mellifera) lineage. Experiments on the nuclear transport activity of protein segments and those of the most recent common ancestor (MRCA) sequences revealed that three new NLS motifs evolved in the Csd protein during the post-duplication divergence while other NLS motifs were lost that existed before duplication. A screen for essential and newly evolved amino acids revealed that new motifs in the Csd protein evolved by one or two missense mutations coding for lysine. Amino acids that were predating the duplication were also essential in the acquisition of the C1 motif suggesting that the ex nihilo origin was constrained by preexisting amino acids in the physical proximity. Our data support a model in which stabilizing selection maintains the constancy of nuclear transport function but allowed mutational turnover of the encoding NLS motifs.