bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Acute Increases in Plasma Creatinine after Renin-Angiotensin Blockade with Subsequent Outcomes
Authors: Fu Edouard L. , Trevisan Marco , Clase Catherine M. , Evans Marie , Lindholm Bengt , Rotmans Joris I. , van Diepen Merel , Dekker Friedo W. , Carrero Juan-Jesus 
Published: August 2019

Background and objectives
Data from observational and interventional studies provide discordant results regarding the relationship between creatinine increase after renin-angiotensin system inhibition (RASi) and adverse outcomes. We compared health outcomes among patients with different categories of increase in creatinine upon initiation of RASi in a large population-based cohort.

Design, setting, participants, & measurements
We performed a retrospective analysis of the Stockholm CREAtinine Measurements database, which contains complete information on diagnoses, medication dispensation claims, and laboratory test results for all Stockholm citizens accessing health care. Included were 31,951 adults initiating RASi during 2007–2011 with available pre- and postinitiation creatinine monitoring. Multivariable Cox regression was used to compare mortality, cardiovascular and ESKD events among individuals with different ranges of creatinine increases within 2 months after starting treatment.

Results
In a median follow-up of 3.5 years, acute increases in creatinine were associated with mortality (3202 events) in a graded manner: compared with creatinine increases <10%, a 10%–19% increase showed an adjusted hazard ratio (HR) of 1.15 (95% confidence interval [95% CI], 1.05 to 1.27); HR 1.22 (95% CI, 1.07 to 1.40) for 20%–29%; HR 1.55 (95% CI, 1.36 to 1.77) for ≥30%. Similar graded associations were present for heart failure (2275 events, P<0.001) and ESKD (52 events; P<0.001), and, less consistently, myocardial infarction (842 events, P=0.25). Results were robust across subgroups, among continuing users, when patients with decreases in creatinine were excluded from the reference group, and after accounting for death as a competing risk.

Conclusions
Among real-world monitored adults, increases in creatinine (>10%) after initiation of RASi are associated with worse health outcomes. These results do not address the issue of discontinuation of RASi when plasma creatinine increases but do suggest that patients with increases in creatinine have higher subsequent risk of cardiovascular and kidney outcomes.
Investigating the Relationship Between Type 2 Diabetes and Dementia Using Electronic Medical Records in the GoDARTS Bioresource
Authors: Doney Alex S.F. , Bonney Wilfred , Jefferson Emily , Walesby Katherine E. , Bittern Rachel , Trucco Emanuele , Connelly Peter , McCrimmon Rory J. , Palmer Colin N.A. 
Published: August 2019

OBJECTIVE
To investigate the impact of type 2 diabetes on incidence of major dementia subtypes, Alzheimer and vascular dementia, using electronic medical records (EMR) in the GoDARTS bioresource.

RESEARCH DESIGN AND METHODS
GoDARTS (Genetics of Diabetes Audit and Research in Tayside Scotland) comprises a large case-control study of type 2 diabetes with longitudinal follow-up in EMR. Dementia case subjects after recruitment were passively identified in the EMR, and using a combination of case note review, an Alzheimer-specific weighted genetic risk score (wGRS), and APOE4 genotype, we validated major dementia subtypes. We undertook a retrospective matched cohort study to determine the risk of type 2 diabetes status for incident dementia accounting for competing risk of death.

RESULTS
Type 2 diabetes status was associated with a significant risk of any dementia (cause-specific hazard ratio [csHR] 1.46, 95% CI 1.31–1.64), which was attenuated, but still significant, when competing risk of death was accounted for (subdistribution [sd]HR 1.26, 95% CI 1.13–1.41). The accuracy of EMR-defined cases of Alzheimer or vascular dementia was high—positive predictive value (PPV) 86.4% and PPV 72.8%, respectively—and wGRS significantly predicted Alzheimer dementia (HR 1.23, 95% CI 1.12–1.34) but not vascular dementia (HR 1.02, 95% CI 0.91–1.15). Conversely, type 2 diabetes was strongly associated with vascular dementia (csHR 2.47, 95% C 1.92–3.18) but not Alzheimer dementia, particularly after competing risk of death was accounted for (sdHR 1.02, 95% CI 0.87–1.18).

CONCLUSIONS
Our study indicates that type 2 diabetes is associated with an increased risk of vascular dementia but not with an increased risk of Alzheimer dementia and highlights the potential value of bioresources linked to EMR to study dementia.
Atrial natriuretic peptide predicts disease progression and digital ulcers development in systemic sclerosis patients
Authors: Romaniello Antonella , Rubattu Speranza , Gigante Antonietta , Simonelli Francesca , Grimaldi Maria C. , D’Angelo Adriano , Alunni Danilo , Sada Lidia , Gasperini Maria L. , Marchitti Simona , Volpe Massimo , Rosato Edoardo 
Published: August 2019

Aims
Systemic sclerosis (SSc) is an autoimmune disease characterized by micro/macrovascular damage due to the underlying fibrosis. Markers able to predict the progression of cardiovascular damage, including digital ulcers, in SSc are warranted. We aimed at characterizing the relevance of N-terminal proatrial natriuretic peptide (NT-proANP) and N-terminal probrain natriuretic peptide plasma levels in relation to cardiovascular damage and digital ulcers in a cohort of Italian SSc patients.

Methods
Seventy patients were enrolled (64 women and six men; mean age 56.7 ± 14 years) with a disease duration of 11.1 ± 8.3 years. Clinical, instrumental (nailfold videocapillaroscopy, ECG, transthoracic echocardiography, pulmonary function test with diffusion lung CO), NT-proANP and N-terminal probrain natriuretic peptide plasma levels measurement were performed at baseline. The clinical follow-up lasted 24 months. The statistical approach used to achieve the study objectives included multivariate analysis, receiver operating characteristic curve, Kaplan–Meier and Cox regression analyses.

Results
Both NT-proNPs levels correlated with systolic pulmonary arterial pressure, but only the NT-proANP level correlated with right heart dimension. Both NT-proNPs levels were higher in patients experiencing events at follow-up but only the NT-proANP level significantly predicted the progression of cardiovascular damage, including development of pulmonary arterial hypertension (PAH). NT-proANP levels were higher in patients with digital ulcers and strongly predicted their development.

Conclusion
Our results show that the NT-proANP plasma level significantly correlates with disease progression such as new onset of PAH, worsening of pulmonary hypertension and development of digital ulcers in a cohort of SSc Italian patients. If future studies will confirm our findings, the plasma NT-proANP level could be used in clinical practice as a novel sensitive marker for PAH and digital ulcers development in SSc.
Sewing Thread Consumption for Different Lockstitches of Class 300 Using Geometrical and Multi-Linear Regression Models
Authors: Sarah Malek , Boubaker Jaouachi , Faouzi Khedher , Adolphe Dominique 
Published: August 2019

Abstract
This paper aims to provide rapid and precise methods to allow industrials to predict the amount of sewing thread needed to sew a garment using different lockstitches of class 300 (301, 301/301, 304, 308, 309, 310, 311, 312, and 315). To avoid unused stocks for each stitch type, a sewing consumption value was determined using a geometrical method of different lockstitch shapes. Furthermore, the relationships between overall geometrical models of the studied lockstitches of class 300 were developed. Indeed, based on the geometrical model of lockstitch type 301, all theoretical models proposed were investigated and proved to be accurate. Moreover, referring to the findings, the prediction of the sewing thread consumption relative to each investigated lockstitch was proposed as a function of the studied input parameters. To improve the established models using geometrical technique, a statistical method was conducted. In addition, based on multi-linear regression, compared geometrical and statistical results were discussed and the coefficient R2 value was determined to evaluate the accuracy of the tested methods. By comparing the estimated thread consumption with the experimental ones, we concluded that the accuracy of the models is significant (R2 ranged from 93.91% to 99.10%), which encourages industrialists to use geometrical models to predict thread consumption. Therefore, the accuracy of prediction using the geometrical method is more accurate than the statistical method regarding the range of R2 (from 92.84% to 97.87%). To classify the significance of all studied parameters, their contributions to the sewing thread consumption behavior were analyzed in the experimental design of interest. It was concluded that the most important parameters affecting thread consumption are stitch width, stitch density, and the gap between two needles. The thickness of fabric has a low contribution to the thread consumption value, whereas the effect of yarn count can be neglected.
Human Mobility in the Final Eneolithic Population of Święte, Jarosław District, South-Eastern Poland: Evidence from Strontium Isotope Data
Authors: Belka Zdzislaw , Dopieralska Jolanta , Szczepanek Anita , Jarosz Paweł 
Published: August 2019

Abstract
Strontium isotope ratios (87Sr/86Sr) were applied to investigate provenance amongst the Final Eneolithic population at Święte (sites 11, 15 and 20) in the Subcarpathian region, south-eastern Poland. The study used 11 human enamel samples collected from the niche graves of the Corded Ware culture. To obtain base-line information on the local Sr isotope composition seven animal enamel samples were also examined. They were found in the adjacent archaeological sites of the Mierzanowice culture at Mirocin and Dobkowice, which have the same environmental and geological background as the sites at Święte. The investigated individuals from Święte display a wide spectrum of Sr isotope signatures, from 0.7094 to 0.7109. Because a comparison of human 87Sr/86Sr values from Święte with Sr animal signatures from Early Bronze Age sites in the area is not unambiguous the local range of 87Sr/86Sr values were based on published data for the Subcarpathian population of the Corded Ware culture. Strontium isotope ratios indicate that only three males with the most radiogenic 87Sr/86Sr values exhibit local signatures. Values below 0.7103 document individuals born outside of the Subcarpathian region. Among these are all women and children, two males and one individual with undetermined sex. The probable homeland of the non-local individuals were areas along the northern and eastern margins of the Carpathian Foredeep in Poland and Ukraine.
ARTs in wild felid conservation programmes in Poland and in the world
Authors: Kochan Joanna , Niżański Wojciech , Moreira Nei , Cubas Zalmir Silvino , Nowak Agnieszka , Prochowska Sylwia , Partyka Agnieszka , Młodawska Wiesława , Skotnicki Józef 
Published: August 2019

Abstract
With the exception of the domestic cat, all felid species (Felidae) are currently threatened with extinction in their natural habitat. To develop effective and optimal wild cat conservation programmes with assisted reproductive technology (ART) it is necessary to combine advances from different disciplines of science, starting from the biology of the species, through research into the population and habitat, assisted reproductive technologies, establishment of gene banks, developing bioinformatic systems, and ending with biodiversity and endangered species management. In the last few years knowledge of felid reproduction has expanded considerably thanks to comparative studies utilising the domestic cat as a research model for endangered wild cats. Basic reproductive techniques utilised in both domestic cat breeding and rescuing wild felid populations that are threatened with extinction include semen collection and cryopreservation, artificial insemination, oocyte collection, in vitro maturation, in vitro fertilisation, somatic cloning, and embryo transfer. The main directions in which assisted reproductive technologies are being developed in wild cat conservation implementations and the contribution of Polish research centres in advancing these methods are presented.
Plasma metabolic characterisation of dairy cows with inactive ovaries and oestrus during the peak of lactation
Authors: Song Yu-Xi , Hu Pan , Bai Yun-Long , Zhao Chang , Xia Cheng , Xu Chuang 
Published: August 2019

Abstract

Introduction
Differential metabolites (DMs) between cows with inactive ovaries (IO) and oestrous (E) cows were screened and metabolic pathways of DMs associated with IO were determined.

Material and Methods
Cows at 50 to 60 days (d) postpartum from an intensive dairy farm were randomly selected and allocated into an E group (n = 16) or an IO group (n = 16) according to a pedometer and rectal examinations. Their plasma samples were analysed by liquid chromatography–mass spectrometry (LC–MS) to compare plasma metabolic changes between the E and IO groups. Multivariate pattern recognition was used to screen the DMs in the plasma of IO cows.

Results
Compared with normal E cows, there were abnormalities in 20 metabolites in IO cows, including a significantly decreased content (VIP > 1, P < 0.05) of cholic acid, p-chlorophenylalanine, and arachidonic acid, and a significantly increased content (VIP > 1, P < 0.05) of tyramine, betaine, L-phenylalanine, L-glutamate, D-proline, L-alanine, and L-pyrophosphate. Five DMs (cholic acid, D-proline, L-glutamate, L-alanine, and L-pyroglutamic acid) with higher variable importance in projection (VIP) values between groups were validated by ELISA with blind samples of re-selected cows (IO, 50 to 60 d postpartum) and the validated results were consistent with the LC–MS results.

Conclusion
The 20 DMs in IO cows during the peak of lactation indicated that the pathogenesis of IO was involved in complex metabolic networks and signal transduction pathways. This study provides a basis for further exploration of the pathogenesis and prevention of IO in cows in the future.
New Parties and Democracy in Slovenia
Authors: Malčič Matevž , Krašovec Alenka 
Published: August 2019

Abstract
While no stranger to new political parties, Slovenia’s party system became much more unstable after 2008 with the constant arrival of electorally very successful parties. Further, while the citizens’ satisfaction with democracy and trust in political institutions has never reached the heights seen in Western Europe, the crisis years saw them drop to historical lows. In these circumstances, one may expect successful new parties to assure greater responsiveness, or a balance between responsible and responsive politics, and to bring improvements to citizens’ opinion on their satisfaction with democracy and trust in political institutions. In addition, new parties are usually more prone to democratic innovations, which can be associated with the popular idea of introducing stronger intra-party democracy in their internal functioning. The analysis shows that in 2014 Slovenia experienced both the nadir of public opinion on democracy and the political system, and the most electorally successful new party. Nevertheless, improvements in satisfaction with democracy and the political system only slowly emerged after 2014, to a considerable extent coinciding with the return to economic prosperity, while even these improvements left enough room for yet another successful new party at the 2018 elections. Concerning innovations in intra-party democracy, we are only able to identify some smaller democratic innovations. Given this, it seems that the new parties themselves have had a relatively limited impact on democracy in Slovenia.
Effect of Agripreneurship on Employment and Income Generation in Cattle Fattening Business in Nigeria
Authors: Obayelu Abiodun Elijah , Olaniyi Ajibola , Ogbe Agatha 
Published: August 2019

Abstract
Unemployment is a major issue in Nigeria because the youth finds it difficult or impossible to secure jobs that meet their expectations. There appears to be a mismatch between graduate skills and those sought by employers. The study investigated the effect of International Institute of Tropical Agriculture (IITA) youth Agripreneurs (IYA) programme on employment and income generation on cattle fattening enterprise under the N2Africa Borno youth project. A two-stage sampling procedure was used to select IYA participants and non-participants. Results revealed that the majority of respondents were males in both categories. It also indicated that youths who are in their productive age are more into cattle fattening enterprise in both categories. The study also found that, unemployment and skill acquisition are the main driving reasons for participating in IYA. It also indicated that both categories of respondents’ required external capital support for start-up of their enterprise, and that IYA programme participants on the average earn more income per month than non-participants. IYA programme participants generated more employment opportunities which implied that the programme had not only empowered participants but also made the participants’ become employers. The study recommended that there is a need to support youths with funds, access to trainings on capacity development and skill acquisition to make them self-employed and job creators.
Trombotic microangiopathy and b-lymphoblastic leukaemia: rare combination or related condition?
Authors: Aksenova M. E. , Generalova G. A. , Khachatryan L. A. 
Published: August 2019

THE AIM:to show a rare combination and possible pathogenetic relationship of thrombotic microangiopathy and acute lymphoblastic leukemia in a child.PATIENTS AND METHODS.The analysis of the history and clinical laboratory data of the patient.RESULTS.9 months after the debut of thrombotic microangiopathy with damage to the central nervous system, acute lymphoblastic leukemia was diagnosed in the form of transient attacks of cerebral circulation and kidneys with the development of the nephrotic syndrome. The literature data show that in rare cases secondary thrombotic microangiopathy precedes the unfolded picture of hematologic disease, pathogenetic therapy of leukemia leads to remission of thrombotic microangiopathy. The article discusses the possible relationship between the two states in a child.CONCLUSION.Although the relationship of thrombotic microangiopathy and acute leukemia in the present case is not obvious, the authors believe that it is necessary to remember about the possibility of developing secondary microangiopathy on the background of oncohematological diseases, and in doubtful cases to conduct a study of the bone marrow in patients.
Pengaruh Motivasi Karyawan Terhadap Kinerja Karyawan Di Pt. Xyz
Authors: Agnesia Inriana Tiara 
Published: August 2019

The purpose of this research is to find out the variables that affect the employee performances in PT. XYZ. The population consist of employee of PT. XYZ using probability sampling method that of 127 respondents, 85 (67%) were male and 42 (33%) were women.. Data analysis using multiple regression analysis technique. The results of the testing of hypotheses shows that physical work environment, remuneration, status, social work environment, recognition, supervision, work itself, achievement has significant influence to employee performances.
Pengaruh Kepemimpinan, Komitmen Organisasi, Kepuasan Kerja, Dan Balance Scorecard Terhadap Kinerja Karyawan Pt Xyz Di Jakarta
Authors: Oktaviani Rizki 
Published: August 2019

The purpose of this study are: First, to explore the effect of leadership on employees performance. Second, to explore the effect of organizational commitment on employees performance. Third, to explore the effect of job satisfaction on employees performance. Fourth, to explore the effect of balance scorecard on employees performance. Fifth, to explore the effect of leadership, organizational commitment, job satisfaction, and balance scorecard on employees performance. The population of this research are all employees of PT XYZ. This research uses a quantitative approach. The method of data collection is purposive sampling with 175 respondents. Data is collected using a questionnaire. The technique of data analysis used in this study was regression analysis to examine the hypotheses. The results are: (1) leadership has a significant effect on employees performance; (2) organizational commitment no significant effect on employees performance; (3) job satisfaction has a significant effect on employees performance; (4) balance scorecard has a significant effect on employees performance; (5) leadership, organizational commitment, job satisfaction and balance scorecard have a significant effect toward employees performance.
Analisis Perkembangan Tingkat Kesehatan Bpr Xyz Tahun 2014 – 2016 Dengan Menggunakan Metode Camel
Authors: Lie Virnando 
Published: August 2019

The rule of banking is very important in an economy because in its operational activities the bank has several functions, such as an intermediary functions that bridges the interests of the party who has excess fund (creditor funds) with the party in need of fund (borrower / debtor). Based on the provisions of Bank Indonesia that in order to maintain the security of cutomers, all Indonesian banking institution are obliged to report their performance to The Financial Service Authority (OJK) and always adhere to the provisions of the law prevailing in the region of Indonesia. Therefore all banking institution in Indonesia will be assessed its performance by using CAMEL Methods,with five aspects of banking assessment such as Capital, Assets, Managements, Earning and Liquidity. This assessment is quantitative descriptive research method. For the result, we used a primary data obtained through questionnaires and secondary data in the form of financial statements balance sheet and income statement of PT BPR XYZ between 2014 to 2016. According to health assessment Bank Perkreditan Rakyat (BPR), based on Decree of the Board of Directors of Bank Indonesia No.30/12/KEP/DIR/1997, The result of financial statement PT BPR XYZ of three years period (2014 – 2016) assessments and based on some benchmarks to determine the reliability of the bank after assessment of each variable, we found that the PT BPR XYZ has good banking performance (credit score more than 81 which is the minimum score of good banking performance).
Kinerja Keuangan Dan Potensi Kebangkrutan Dari Perusahaan Transportasi Pelayaran Pada Tahun 2013-2017
Authors: Carunia Mulya Firdausy Aditya Budi Kurniawan Dan 
Published: August 2019

The purpose of this study is to analyze the financial performance and potential bankruptcy of shipping transportation companies listed in the Indonesia Stock Exchange in 2013-2017. the method to estimate financial performance and bankruptcy prediction is by using financial ratio & Altman Z-Score method. The results show that the majority of companies indicating there is a signs of improving financial performance when commodity prices begin to recover. In addition to the analysis of the Altman Z-score bankruptcy Based on the Z-score value of the 14 sample companies, in 2013 there were 5 companies in the healthy category (z-score> 2.60), however in 2016 this number decreased to 3 companies . Whereas for companies that are in the grey area category (z-score 1.1-2.60) in 2013 there were 4 companies and then declined to the remaining 3 companies in 2016. Whereas in 2013 company is in the category of financial distress (z-score <1 , 1) there are 5 companies and increased to 8 companies in 2016. In 2017 there was an increase in the companies in the healthy category & grey area each into 4 companies. While companies in the financial distress category are reduced to 6 companies. This means there are improvements in 2017.