bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unexpected therapeutic effects of cisplatin
Authors: Raudenska Martina , Balvan Jan , Fojtu Michaela , Gumulec Jaromir , Masarik Michal 
Published: April 2019

AbstractCisplatin is a widely used chemotherapeutic agent that is clinically approved to fight both carcinomas and sarcomas. It has relatively high efficiency in treating ovarian cancers and metastatic testicular cancers. It is generally accepted that the major mechanism of cisplatin anti-cancer action is DNA damage. However, cisplatin is also effective in metastatic cancers and should, therefore, affect slow-cycling cancer stem cells in some way. In this review, we focused on the alternative effects of cisplatin that can support a good therapeutic response. First, attention was paid to the effects of cisplatin at the cellular level such as changes in intracellular pH and cellular mechanical properties. Alternative cellular targets of cisplatin, and the effects of cisplatin on cancer cell metabolism and ER stress were also discussed. Furthermore, the impacts of cisplatin on the tumor microenvironment and in the whole organism context were reviewed. In this review, we try to reveal possible causes of the unexpected effectiveness of this anti-cancer drug.
Tetrandrine inhibits colon carcinoma HT-29 cells growth via the Bcl-2/Caspase 3/PARP pathway and G1/S phase
Authors: Li JiaNan , Wang QiuHong , Wang ZhiBin , Cui Na , Yang BingYou , Niu WenYing , Kuang HaiXue 
Published: April 2019

Abstract
Tetrandrine (Tet) bisbenzylisoquinoline alkaloids isolated from Stephania tetrandra and other related species of Menispermaceae. It has been demonstrated to have positive therapeutic effects on cardiovascular disease, hypertension, silicosis, autoimmune diseases. In recent years, some reports have shown that Tet has anticancer activity in human cancers. To explore the pharmacological activity and mechanism of Tet on colon cancer and its unique advantages as a natural product. In the present study, analyses of the cell cycle, apoptosis, targets prediction, molecular docking, and alterations in protein levels were performed to elucidate how Tet functions in colon cancer. We found that Tet robustly induced arrest at the G1 phase in colon cancer cell line HT-29. It induced HT-29 cell apoptosis in a dose-dependent manner. Similarly, analysis of protein expression levels in HT-29 cells showed down-regulation of Bcl-2, pro-caspase 3, pro-caspase 8, PARP, cyclin D1 (CCND1), cyclin-dependent kinase 4 (CDK 4), and up-regulation of Bax, active caspase 3, and active caspase 8. These results indicate that Tet induces apoptosis of colon cancer cells through the mitochondrial pathway and caspase family pathway. Molecular docking showed interaction effects and binding energy. Comparing with the CDK4 inhibitors ribociclib and palbociclib, the docking energy is similar to the docked amino acid residues. Therefore, we conclude that Tet and the CCND1/CDK4 compound could form hydrogen bonds and a stable compound structure, which can inhibit colon cancer cells proliferation by regulating CCND1/CDK4 compound and its downstream proteins phosphorylated Rb (p-Rb). In summary, Tet may be a potential drug for colon cancer therapy.
NSD2 silencing alleviates pulmonary arterial hypertension by inhibiting trehalose metabolism and autophagy
Authors: Zhou Xue-liang , Liu Zhi-bo , Zhu Rong-rong , Huang Huang , Xu Qi-rong , Xu Hua , Zeng Liang , Li Yun-yun , Huang Cha-hua , Wu Qi-cai , Liu Ji-chun 
Published: April 2019

Abstract
Nuclear receptor binding SET domain 2 (NSD2)-mediated metabolic reprogramming has been demonstrated to regulate oncogenesis via catalyzing the methylation of histones. The present study aimed to investigate the role of NSD2-mediated metabolic abnormality in pulmonary arterial hypertension (PAH). Monocrotaline (MCT)-induced PAH rat model was established and infected with adeno-associated virus carrying short hairpin RNA (shRNA) targeting NSD2. Hemodynamic parameters, ventricular function, and pathology were evaluated by microcatheter, echocardiography, and histological analysis. Metabolomics changes in lung tissue were analyzed by LC–MS. The results showed that silencing of NSD2 effectively ameliorated MCT-induced PAH and right ventricle dysfunction, and partially reversed pathological remodeling of pulmonary artery and right ventricular hypertrophy. In addition, the silencing of NSD2 markedly reduced the di-methylation level of H3K36 (H3K36me2 level) and inhibited autophagy in pulmonary artery. Non-targeted LC–MS based metabolomics analysis indicated that trehalose showed the most significant change in lung tissue. NSD2-regulated trehalose mainly affected ABC transporters, mineral absorption, protein digestion and absorption, metabolic pathways, and aminoacyl-tRNA biosynthesis. In conclusion, we reveal a new role of NSD2 in the pathogenesis of PAH related to the regulation of trehalose metabolism and autophagy via increasing the H3K36me2 level. NSD2 is a promising target for PAH therapy.
Effects of climate change on vector-borne diseases: an updated focus on West Nile virus in humans
Authors: Paz Shlomit 
Published: April 2019

Abstract
One of the main impacts of climate change on health is the influence on vector-borne diseases (VBDs). During the last few years, yearly outbreaks of the West Nile virus (WNV) have occurred in many locations, providing evidence of ongoing transmission. Currently, it is the most widely distributed arbovirus in the world. Increases in ambient temperature have impacts on WNV transmission. Indeed, clear associations were found between warm conditions and WNV outbreaks in various areas. The impact of changes in rainfall patterns on the incidence of the disease is influenced by the amount of precipitation (increased rainfall, floods or droughts), depending on the local conditions and the differences in the ecology and sensitivity of the species of mosquito. Predictions indicate that for WNV, increased warming will result in latitudinal and altitudinal expansions of regions climatically suitable for transmission, particularly along the current edges of its transmission areas. Extension of the transmission season is also predicted. As models show that the current climate change trends are expected to continue, it is important to reinforce WNV control efforts and increase the resilience of population health. For a better preparedness, any assessment of future transmission of WNV should consider the impacts of the changing climate.
Listening Difficulties in Children With Fetal Alcohol Spectrum Disorders: More Than a Problem of Audibility
Authors: McLaughlin Susan A. , Thorne John C. , Jirikowic Tracy , Waddington Tiffany , Lee Adrian K. C. , Astley Hemingway Susan J. 
Published: April 2019

PurposeData from standardized caregiver questionnaires indicate that children with fetal alcohol spectrum disorders (FASDs) frequently exhibit atypical auditory behaviors, including reduced responsivity to spoken stimuli. Another body of evidence suggests that prenatal alcohol exposure may result in auditory dysfunction involving loss of audibility (i.e., hearing loss) and/or impaired processing of clearly audible, “suprathreshold” sounds necessary for sound-in-noise listening. Yet, the nexus between atypical auditory behavior and underlying auditory dysfunction in children with FASDs remains largely unexplored.MethodTo investigate atypical auditory behaviors in FASDs and explore their potential physiological bases, we examined clinical data from 325 children diagnosed with FASDs at the University of Washington using the FASD 4-Digit Diagnostic Code. Atypical behaviors reported on the “auditory filtering” domain of the Short Sensory Profile were assessed to document their prevalence across FASD diagnoses and explore their relationship to reported hearing loss and/or central nervous system measures of cognition, attention, and language function that may indicate suprathreshold processing deficits.ResultsAtypical auditory behavior was reported among 80% of children with FASDs, a prevalence that did not vary by FASD diagnostic severity or hearing status but was positively correlated with attention-deficit/hyperactivity disorder. In contrast, hearing loss was documented in the clinical records of 40% of children with fetal alcohol syndrome (FAS; a diagnosis on the fetal alcohol spectrum characterized by central nervous system dysfunction, facial dysmorphia, and growth deficiency), 16-fold more prevalent than for those with less severe FASDs (2.4%). Reported hearing loss was significantly associated with physical features characteristic of FAS.ConclusionChildren with FAS but not other FASDs may be at a particular risk for hearing loss. However, listening difficulties in the absence of hearing loss—presumably related to suprathreshold processing deficits—are prevalent across the entire fetal alcohol spectrum. The nature and impact of both listening difficulties and hearing loss in FASDs warrant further investigation.
Green synthesis and characterisation of ZnMn2O4 nanoparticles for photocatalytic degradation of Congo red dye and kinetic study
Authors: Taghavi Fardood Saeid , Moradnia Farzaneh , Ramazani Ali 
Published: April 2019

In this work, ZnMn2O4 spinel nanoparticles were successfully synthesised by tragacanth gel through the easy and inexpensive novel sol–gel method. This technique has many strong points such as facile, economical, non‐toxic and quickness in comparison with other methods. The zinc manganite nanoparticles were characterised by X‐ray powder diffraction (XRD), transmission electron microscopy, field emission scanning electron microscopy, Fourier transform infrared spectroscopy and diffuse reflectance spectroscopy. The XRD pattern confirmed the formation of spinel tetragonal structure of ZnMn2O4 nanoparticles with a crystallite size of 14 nm. The degradation of Congo red dye by synthesised nanoparticles was studied using employing UV–Vis spectroscopy. The ZnMn2O4 NPs expressed high photocatalytic activity for degradation of Congo red dye at room temperature in aqueous solution so that 96% of Congo red was degraded in 15 min. The spinel ZnMn2O4 photocatalyst provided total organic carbon removal as 45.2% in 15 min. The spinel ZnMn2O4 NPs reusability was examined by administering the degradation of Congo red dye with the spent catalyst and it was considered that the photocatalyst did not exhibit any significant reduction in its activity even after three cycles.
NGTS-5b: a highly inflated planet offering insights into the sub-Jovian desert
Authors: Eigmüller Philipp , Chaushev Alexander , Gillen Edward , Smith Alexis , Nielsen Louise D. , Turner Oliver , Csizmadia Szilard , Smalley Barry , Bayliss Daniel , Belardi Claudia , Bouchy François , Burleigh Matthew R. , Cabrera Juan , Casewell Sarah L. , Chazelas Bruno , Cooke Benjamin F. , Erikson Anders , Gänsicke Boris T. , Günther Maximilian N. , Goad Michael R. , Grange Andrew , Jackman James A. G. , Jenkins James S. , McCormac James , Moyano Maximiliano , Pollacco Don , Poppenhaeger Katja , Queloz Didier , Raynard Liam , Rauer Heike , Udry Stéphane , Walker Simon. R. , Watson Christopher A. , West Richard G. , Wheatley Peter J. 
Published: April 2019

Context. Planetary population analysis gives us insight into formation and evolution processes. For short-period planets, the sub-Jovian desert has been discussed in recent years with regard to the planet population in the mass/period and radius/period parameter space without taking stellar parameters into account. The Next Generation Transit Survey (NGTS) is optimised for detecting planets in this regime, which allows for further analysis of the sub-Jovian desert.
Aims. With high-precision photometric surveys (e.g. with NGTS and TESS), which aim to detect short period planets especially around M/K-type host stars, stellar parameters need to be accounted for when empirical data are compared to model predictions. Presenting a newly discovered planet at the boundary of the sub-Jovian desert, we analyse its bulk properties and use it to show the properties of exoplanets that border the sub-Jovian desert.
Methods. Using NGTS light curve and spectroscopic follow-up observations, we confirm the planetary nature of planet NGTS-5b and determine its mass. Using exoplanet archives, we set the planet in context with other discoveries.
Results. NGTS-5b is a short-period planet with an orbital period of 3.3569866 ± 0.0000026 days. With a mass of 0.229 ± 0.037 MJup and a radius of 1.136 ± 0.023 RJup, it is highly inflated. Its mass places it at the upper boundary of the sub-Jovian desert. Because the host is a K2 dwarf, we need to account for the stellar parameters when NGTS-5b is analysed with regard to planet populations.
Conclusions. With red-sensitive surveys (e.g. with NGTS and TESS), we expect many more planets around late-type stars to be detected. An empirical analysis of the sub-Jovian desert should therefore take stellar parameters into account.
„Entschleunigtes Atmen“ – Zentrales psychosomatisches
Angebot in der Ordnungstherapie
Authors: Loew Thomas H. , Leinberger Beate 
Published: April 2019

ZusammenfassungDie Atmung hat Einfluss auf unseren Körper und dient letztlich dem Zweck,
Sauerstoff in benötigter Menge aufzunehmen. Aber die Atmung dient auch zu
Regulationszwecken, und wir können sie willentlich beeinflussen. Mittels des
langsamen, bewussten Atmens können Organfunktionen reguliert werden. Es fußt auf
dem Prinzip, dem Körper vorzugaukeln, er schliefe. Der Beitrag zeigt, wie das
entschleunigte Atmen erlernt werden kann, welchen klinischen Nutzen es als
ordnungstherapeutisches Element hat und gibt einen Überblick über die aktuelle
Studienlage.
Ruthenium-Catalyzed Selective Reduction of Carboxylic Esters and Carboxamides
Authors: Zhou Yongyun , Khan Ruhima , Fan Baomin , Xu Lijin 
Published: April 2019

Amines and alcohols are important classes of building blocks in organic synthesis. The synthesis of these compounds has been a topic of interest. A straightforward method for their synthesis is the reduction of esters and amides to alcohols and amines, respectively. Various transition-metal catalysts have been developed for the homogeneous hydrogenation of esters and amides to alcohols and amines. In this review, an overview of the ruthenium-catalyzed selective hydrogenation of esters and amides is provided.1	General Introduction2	Ru-Catalyzed Reduction of Esters3	Ru-Catalyzed Selective Reduction of Amides4	Conclusions
Disseminated Intravascular Coagulation in Cancer: An Update
Authors: Levi Marcel 
Published: April 2019

AbstractCancer often leads to the activation of coagulation, manifesting as disseminated intravascular coagulation (DIC) in its most extreme form. DIC is characterized by systemic intravascular coagulation activation (leading to deposition of intravascular platelets and fibrin) and simultaneous consumption of coagulation proteins and thrombocytes (which may cause bleeding complications). The clinical course of DIC in patients with malignancies is typically less intense compared with DIC complicating alternative clinical settings, including systemic inflammatory responses following infection or traumatic injury. A more slowly proceeding, less fulminant, and widespread hemostatic derangement can remain asymptomatic. Eventually, the ongoing consumption may result in low levels of platelets and coagulation factors, and bleeding complications (frequently localized at the site of the tumor or distant metastases) may be the first clinical manifestation of DIC. An alternative clinical scenario is dominated by thrombotic complications, ranging from clinically manifest vascular thrombosis to microvascular platelet plugs. The main principle of DIC management is adequate treatment of the precipitating disorder; however, there are clinical presentations that may require additional supportive strategies specifically aimed at the amelioration of the coagulopathy.
Retrosigmoid Transmeatal Approach for Resection of Acoustic Neuroma: Operative Video and Technical Nuances of Subperineural Dissection for Facial Nerve Preservation
Authors: Liu James K. , Dodson Vincent N. , Jyung Robert W. 
Published: April 2019

The retrosigmoid (suboccipital) approach is the workhorse for most acoustic neuromas in the cerebellopontine angle. In this operative video atlas manuscript, the authors demonstrate the nuances of the subperineural dissection technique for microsurgical resection of an acoustic neuroma via the retrosigmoid transmeatal approach. The plane is developed by separating the perineurium of the vestibular nerve away from the tumor capsule. This perineurium provides a protective layer between the tumor capsule and the facial nerve which serves as a buffer to avoid direct dissection and potential trauma to the facial nerve. Using this technique during extracapsular tumor dissection helps to maximize the extent of tumor removal while preserving facial nerve function. A gross total resection of the tumor was achieved, and the patient exhibited normal facial nerve function (Fig. 1). In summary, the retrosigmoid transmeatal approach with the use of subperineural dissection are important strategies in the armamentarium for surgical management of acoustic neuromas with the goal of maximizing tumor removal and preserving facial nerve function (Fig. 2).The link to the video can be found at: https://youtu.be/L3lPtSvJt60.
A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Authors: Esfandyarpour R. , Kashi A. , Nemat-Gorgani M. , Wilhelmy J. , Davis R. W. 
Published: April 2019

SignificanceMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease which afflicts approximately 2 million people in the United States and many more around the globe. A combination of factors might trigger ME/CFS, and there is currently no well-established blood-based biomarker to diagnose it. Taking advantage of advancements in micro/nanofabrication, direct electrical detection of cellular and molecular properties, microfluidics, and artificial intelligence techniques, we developed a nanoelectronics blood-based assay that can potentially establish a diagnostic biomarker and a drug-screening platform for ME/CFS. Given the significance of this assay, we envision it has the potential to be widely employed in research laboratories and clinics in the future as an aid to physicians as well as to our colleagues in the ME/CFS research community.
Tumor-suppressive activity of Hnf1β in Wilms’ tumor
Authors: Liu Yamin , Kanyomse Quist , Xie Yajun 
Published: April 2019

ABSTRACTHepatocyte nuclear factor 1β (HNF1β) is a transcription factor belonging to the HNF-1 family and has been implicated in a number of cancers, but its role in Wilms’ tumor (nephroblastoma) has not been addressed. Here, we compared its expression between Wilms’ tumor patient kidney tissue and adjacent tissue based on the Oncomine database (www.oncomine.com). Cell proliferation, apoptosis, migration, and HNF1β expression level were analyzed in Wilms’ tumor-derived G401 cells. Using a variety of mouse tissues (lung, heart, kidney, etc.), we found that HNF1β is the highest expression in the kidneys. Oncomine analysis further demonstrated that HNF1β has a lower expression in Wilms’ tumor tissue than in paracancerous tissues. Overexpression of HNF1β decreased cell proliferation and migration, but promoted cell apoptosis. Knockdown of HNF1β produced the opposite results. These results indicated that HNF1β may play important roles in kidney development and function, and its activation may negatively regulate Wilms’ tumor progression.
Shared Musical Experiences
Authors: Polite Brandon 
Published: April 2019

Abstract
In ‘Listening to Music Together’, Nick Zangwill offers three arguments which aim to establish that listening to music can never be a joint activity. If any of these arguments were sound, then our experiences of music, qua object of aesthetic attention, would be essentially private. In this paper, I argue that Zangwill’s arguments are unsound and I develop an account of shared musical experience that defends three main conclusions. First, joint listening is not merely possible but a common feature of our socially situated experiences of music. Second, when listening with others our experience of the music and our sense of community with our fellow listeners often reciprocally enhance one another. Third, how deeply and intimately we share a musical experience with others depends upon such factors as our respective backgrounds, interests, and levels of expertise.
Plenty of room left for the Dogmatist
Authors: Raleigh Thomas 
Published: April 2019

Abstract
Barnett (2019) provides an interesting new challenge for Dogmatist accounts of perceptual justification. The challenge is that such accounts, by accepting that a perceptual experience can provide a distinctive kind of boost to one’s credences, would lead to a form of diachronic irrationality in cases where one has already learnt in advance that one will have such an experience. I show that this challenge rests on a misleading feature of using the 0–1 interval to express probabilities and show that if we switch to using Odds or (better) Log-Odds, the misleading appearance that there is only ‘a little room’ for one’s credences to increase evaporates. Moreover, there are familiar, independent reasons for taking the Log-Odds scale to provide a clearer picture of the confirmatory effect of evidence. Thus the Dogmatist can after all escape the charge of diachronic irrationality.
Crimes of the Senses: Yarn Bombing and Aesthetic Criminology
Authors: Millie Andrew 
Published: April 2019

Abstract
Yarn bombing involves the display of knitted or crocheted items in public space, often without permission. This article draws on interviews with yarn bombers in the North West of England and considers who the yarn bombers are, their motivations and experiences and their views on the legal status of yarn bombing. Although the visual is important for yarn bombing—and it is therefore of interest to visual criminology—this article also looks further to consider other sensory experience. In this way, it contributes to an emerging aesthetic criminology concerned with broader sensory, affective and emotive experience. Drawing on Thrift’s work on urban affect or mood, as well as Anderson and Young on affective atmospheres, yarn bombing is regarded as a crime of the senses affecting both the look and the feel of the city. The scope for further development of an aesthetic criminology is suggested, including specific methodologies that embrace the full range of sensory experiences associated with crime, disorder or social harm.