bluuebunny/crossref_metadata_2025_split huggingface dataset:
Balancing the cart: Milk, plant‐based alternatives and nutrient availability in New Zealand households
Authors: Cleland Josiah , Fernandez Mario A. , Villa‐Cox Gonzalo 
Published: November 2024

AbstractMilk is a near‐universal source of essential nutrients and contributes significantly to global nutrient availability. Global demand for milk continues to rise, driven by population growth, rising household incomes and favourable consumption patterns. Plant‐based alternatives (PBAs) to milk seek to cater to the preferences of a share of consumers regarding sustainability, lifestyle or health‐related matters (e.g. allergies and lactose intolerance). Though popular, PBAs do not stand as suitable nutritional substitutes for milk. These considerations emphasise the complex relationships between nutritional content and consumer preferences. This paper estimates a demand system for milk and PBAs in the New Zealand (NZ) market. We explore patterns of complementarity or substitutability between standard milk, reduced‐fat milk and organic milk, and an aggregate group of PBAs. We use these results to calculate nutrient elasticities and assess changes in nutrient availability in response to prices and expenditure variations. We estimate a Quadratic Almost Ideal Demand System using purchase records for 2460 NZ households in 2021. We find that demand for standard milk does not show any substitutional relationship with PBAs. On the contrary, increases in the PBAs price lead households to switch towards standard milk, thereby increasing the availability of essential nutrients. That is, in the case of price increases, milk effectively offsets the reduction in essential nutrients as households switch away from PBAs, but PBAs cannot offset any reduction in essential nutrients as households do not find them to be adequate substitutes for milk.
Examining the impact of the veterans affairs community care program on mental healthcare in rural veterans: A qualitative study
Authors: Kenneally Lauren , Riblet Natalie , Stevens Susan , Rice Korie , Scott Robert 
Published: November 2024

AbstractObjectiveTo investigate provider and administrators' perspectives about the impact of the Department of Veterans Affairs' (VA) Community Care program on acute and residential mental health treatment of rural Veterans.Data Sources and Study SettingPrimary data were collected from participants via interviews. Participants were employees of VA Healthcare Systems located in Northern New England, or employees of non‐VA mental health treatment settings affiliated with VA in Northern New England.Study DesignThis study was informed by the Consolidated Framework for Implementation Research (CFIR), with Community Care as the implemented program. Individual, semi‐structured interviews were conducted.Data Collection/Extraction MethodsIndividual interviews were transcribed, coded deductively using the CFIR, and inductively coded by locating themes.Principal FindingsTwenty‐one people completed interviews. Commonly reported challenges included community programs not focused on Veterans' needs, poor coordination of care, communication challenges, and problems tracking Veteran care. Facilitators included increased access to care and strengthening coordination of care.ConclusionsThe VA's Community Care program can address the acute or residential mental health needs of Veterans in rural settings in some circumstances, however there are challenges to successful implementation.
Clinical effectiveness of baricitinib and abatacept in patients with rheumatoid arthritis
Authors: Asai Shuji , Takahashi Nobunori , Terabe Kenya , Yoshioka Yutaka , Kojima Toshihisa , Kobayakawa Tomonori , Sobue Yasumori , Watanabe Tatsuo , Hirano Yuji , Kanayama Yasuhide , Kato Takefumi , Hanabayashi Masahiro , Suzuki Mochihito , Imagama Shiro 
Published: November 2024

AbstractAimThe objective of this study was to compare the clinical effectiveness of baricitinib and abatacept in patients with rheumatoid arthritis (RA).MethodsThis study included 274 patients treated with abatacept and 241 treated with baricitinib who were followed for >52 weeks. Potential treatment selection bias was addressed by using inverse probability of treatment weighting. The paired t‐test was used to assess differences in Clinical Disease Activity Index (CDAI) score relative to baseline. A generalized estimating equation was used to compare the two treatment groups.ResultsThe estimated mean CDAI score was 18.2 at baseline and significantly decreased to 12.6 at 4 weeks, 8.9 at 12 weeks, 7.4 at 24 weeks, and 6.1 at 52 weeks in the abatacept group. The estimated mean CDAI score was 18.6 at baseline and significantly decreased to 9.5 at 4 weeks, 6.5 at 12 weeks, 5.7 at 24 weeks, and 5.5 at 52 weeks in the baricitinib group. The baricitinib group had significantly lower CDAI scores at 4, 12, and 24 weeks compared to the abatacept group. Subgroup analyses revealed that this difference was evident among patients with high disease activity and without concomitant use of methotrexate but was less pronounced among those with remission to moderate disease activity status with methotrexate use.ConclusionBoth baricitinib and abatacept were effective in reducing disease activity in patients with RA. Baricitinib demonstrated potential advantages over abatacept in terms of early disease control, particularly in patients with high disease activity and without methotrexate use.
Influence of reef habitat on coral microbial associations
Authors: Gantt Shelby E. , Kemp Keri M. , Colin Patrick L. , Hoadley Kenneth D. , LaJeunesse Todd C. , Warner Mark E. , Kemp Dustin W. 
Published: November 2024

AbstractCorals have complex symbiotic associations that can be influenced by the environment. We compare symbiotic dinoflagellate (family: Symbiodiniaceae) associations and the microbiome of five scleractinian coral species from three different reef habitats in Palau, Micronesia. Although pH and temperature corresponded with specific host‐Symbiodiniaceae associations common to the nearshore and offshore habitats, bacterial community dissimilarity analyses indicated minimal influence of these factors on microbial community membership for the corals Coelastrea aspera, Psammocora digitata, and Pachyseris rugosa. However, coral colonies sampled close to human development exhibited greater differences in microbial community diversity compared to the nearshore habitat for the coral species Coelastrea aspera, Montipora foliosa, and Pocillopora acuta, and the offshore habitat for Coelastrea aspera, while also showing less consistency in Symbiodiniaceae associations. These findings indicate the influence that habitat location has on the bacterial and Symbiodiniaceae communities comprising the coral holobiont and provide important considerations for the conservation of coral reef communities, especially for island nations with increasing human populations and development.
Proteo‐metabolomic insights for early dual physical and cognitive impairments: A search for biomarkers of healthy aging based on muscle–brain crosstalk
Authors: Huang Yi‐Long , Chang Wei‐Ju , Huang Chen‐Hua , Lin Chao‐Hsiung , Peng Li‐Ning , Chung Chih‐Ping , Chen Liang‐Kung , Lee Wei‐Ju 
Published: November 2024

AbstractWe employed an untargeted proteo‐metabolomic approach to profile circulating biomarkers in plasma samples from the I‐Lan Longitudinal Aging Study, aiming to identify biomarkers and pathways associated with physio‐cognitive decline syndrome (PCDS). In 115 propensity score‐matched PCDS case–control pairs, pathway analyses implicated dysregulation of fatty acid metabolism and inflammation in PCDS pathogenesis. Sex‐specific associations were observed, with disruptions in central carbon metabolism (elevated PKM, MDH1, and GAPDH; decreased MINPP1) and tyrosine metabolism (decreased MIF, DBH; increased thyroxine) characterizing in men. In contrast, perturbations in glutathione and phenylalanine metabolism, including increased ANPEP, GSTP1, and decreased pyroglutamic acid, were identified in women. Results suggest that dysregulated energy and redox homeostasis likely contribute to PCDS development. Notably, ANPEP, PKM, and MIF emerged as potential biomarkers, elucidating the muscle–brain crosstalk framework. Our findings provide insights into potential molecular mechanisms underlying PCDS and the muscle–brain crosstalk, marking progress toward elucidating biomarkers in the journey of healthy aging.
Coronary Angiographic Features of de Winter Syndrome: More Than Just Occlusion of the Left Anterior Descending Artery
Authors: Tang Wenyi , Xu Junwei , Cheng Fangyuan , Liu Tianmin , Lin Zijian , Chen Bairong , Chen Jian , Luo Liyun 
Published: November 2024

ABSTRACTBackgroundThe de Winter electrocardiogram (ECG) pattern is a rare presentation of ST‐segment elevation myocardial infarction (STEMI) equivalent. The clinical profile of de Winter syndrome remains to be clarified.MethodsMedical records of 1865 consecutive patients with acute myocardial infarction admitted from November 2018 to July 2023 were screened. Twelve patients (0.6%) with de Winter syndrome were included. STEMI patients whose culprit vessel was the left anterior descending artery (LAD) but without de Winter ECG pattern were selected as controls after 1:2 matching for age and sex.ResultsThe de Winter syndrome patients were all male, aged 49.0 (46.3–52.5) years. The culprit lesion was the proximal LAD in seven patients (58.3%), the middle LAD in three (25%), the left main coronary artery in one (8.3%), and the ramus intermedius artery in the other. All of their culprit lesions had TIMI Thrombus Grade < 4, Cohen‐Rentrop Score ≤ 2, and residual stenosis ≥ 80% after pretreatment with thrombus aspiration or balloon predilatation. Intracoronary imaging data were available in four patients, showing severe atherosclerotic stenosis. Compared with STEMI, de Winter syndrome had a higher prevalence of prior recurrent angina (75.0% vs. 37.5%, p = 0.034), better coronary collateralization (Cohen‐Rentrop Score: 1 vs. 0, p = 0.001), lower thrombus burden (TIMI grade: 1 vs. 2, p = 0.005) but more severe atherosclerotic stenosis in the culprit lesions (90% vs. 60%, p < 0.001).ConclusionsThe culprit lesions of de Winter syndrome have a low thrombus burden, severe atherosclerotic stenosis, and poor collateral circulation protection.
Targeting RNA modifications in leukaemia: Epitranscriptomic drugs are the new kids on the block
Authors: Esteller Manel 
Published: November 2024

In this article, Chen et al. show that a chemical modification of transfer RNA, along its corresponding RNA modifier enzyme, is diminished in acute myeloid leukaemia. These findings further support the role of an aberrant epitranscriptome in haematological malignancies.Commentary on: Chen et al. Hydroxy‐wybutosine tRNA modifications as indicators of disease progression and therapeutic targets in leukemia. Br J Haematol 2025; 206:517‐530.
Dual effects of mefenamic acid on the IKs molecular complex
Authors: Chan Magnus , Pourrier Marc , Eldstrom Jodene , Sahakyan Harutyun , Vardanyan Vitya , Fedida David 
Published: November 2024

AbstractBackground and PurposeMutations in both KCNQ1 and KCNE1, which together form the cardiac IKs current, are associated with inherited conditions such as long and short QT syndromes. Mefenamic acid, a non‐steroidal anti‐inflammatory drug, is an IKs potentiator and may be utilised as an archetype to design therapeutically useful IKs agonists. However, here we show that mefenamic acid can also act as an IKs inhibitor, and our data reveal its dual effects on KCNQ1/KCNE1 channels.Experimental ApproachEffects of mefenamic acid on wild type (WT) and mutant KCNQ1/KCNE1 channels expressed in tsA201 cells were studied using whole cell patch clamp. Molecular dynamics simulations were used to determine trajectory clustering.Key ResultsMefenamic acid inhibits WT IKs at high concentrations while preserving some attributes of current potentiation. Inhibitory actions of mefenamic acid are unmasked at lower drug concentrations by KCNE1 and KCNQ1 mutations in the mefenamic acid binding pocket, at the extracellular end of KCNE1 and in the KCNQ1 S6 helix. Mefenamic acid does not inhibit KCNQ1 in the absence of KCNE1 but inhibits IKs current in a concentration‐dependent manner in the mutant channels. Inhibition involves modulation of pore kinetics and/or voltage sensor domain‐pore coupling in WT and in the KCNE1 E43C mutant.Conclusion and ImplicationsThis work highlights the importance of structural motifs at the extracellular inter‐subunit interface of KCNQ1 and KCNE1 channels, and their interactions, in determining the nature of drug effects on the IKs channel complex and has important implications for treating patients with specific long QT mutations.
GADD45β‐MTK1 signaling axis mediates oncogenic stress‐induced activation of the p38 and JNK pathways
Authors: Kawataki Saeko , Kubota Yuji , Katayama Kotoe , Imoto Seiya , Takekawa Mutsuhiro 
Published: November 2024

AbstractThe ERK pathway governs essential biological processes such as cell proliferation and survival, and its hyperactivation by various oncogenes ultimately drives carcinogenesis. However, normal mammalian cells typically recognize aberrant ERK signaling as oncogenic stress and respond by inducing cell cycle arrest or apoptosis through activation of the p38 and JNK pathways. Despite the critical role of this response in preventing carcinogenesis, the precise molecular mechanisms underlying oncogene‐induced, ERK‐dependent activation of p38/JNK and its tumor‐suppressive effects remain unclear. Here, we demonstrate that MAP three kinase 1 (MTK1), a stress‐responsive MAPKKK, serves as a key mediator of p38/JNK activation induced by oncogenic ERK signaling. Mechanistically, aberrant ERK signaling induces sustained expression of the transcription factor early growth response protein 1 (EGR1), which promotes the production of the MTK1 activator GADD45β, leading to persistent activation of MTK1‐p38/JNK signaling. Gene knockout and transcriptome analyses revealed that this GADD45β/MTK1‐mediated cross‐talk between the ERK and p38/JNK pathways preferentially upregulates a specific set of genes involved in apoptosis and the immune response. Notably, the expression of EGR1, GADD45β, and MTK1 is frequently downregulated in many cancers with high ERK activity, resulting in the disruption of the tumor‐suppressive ERK‐p38/JNK cross‐talk. Restoring GADD45β expression in cancer cells reactivates p38/JNK signaling and suppresses tumorigenesis. Our findings delineate a molecular mechanism by which normal cells sense and respond to oncogenic stress to prevent abnormal growth, and highlight the significance of its dysregulation in cancer.
A little imprecision goes a long way in launching memory development
Authors: Sloutsky Vladimir M. , Ralston Robby , Turner Brandon M. , Ghetti Simona 
Published: November 2024

AbstractFrom the earliest moments in their lives, infants begin to build memories about their past and accumulate knowledge about the world. In this article, we focus on the distinction between memory for specific events and memory for general information, and the ongoing debate about which type of memory provides the foundation for the development of the other. Some researchers argue that specific memory developmentally precedes general memory, whereas others support the opposite position. Our literature review suggests that the latter position is inconsistent with many empirical findings and theoretical principles of memory captured by computational models capable of accounting for these findings. We propose that just good enough mnemonic acuity could be a starting point for memory development, and that it can support both specific and generalized memories.
PTP1B Modulates Carotid Plaque Vulnerability in Atherosclerosis Through Rab5‐PDGFRβ‐Mediated Endocytosis Disruption and Apoptosis
Authors: Zhang Xiao , Xu Ran , Wang Tao , Li Jiayao , Sun Yixin , Cui Shengyan , Xing Zixuan , Lyu Xintao , Yang Ge , Jiao Liqun , Li Wenjing 
Published: November 2024

ABSTRACTBackgroundProtein tyrosine phosphatase 1B (PTP1B) is a protein tyrosine phosphatase and modulates platelet‐derived growth factor (PDGF)/platelet‐derived growth factor receptor (PDGFR) signaling in vascular smooth muscle cells (VSMCs) via endocytosis. However, the related molecular pathways that participated in the interaction of endo‐lysosome and the trafficking of PDGFR are largely unknown. This study aims to determine the subcellular regulating mechanism of PTP1B to the endo‐lysosome degradation of PDGFR in atherosclerotic carotid plaques, thereby offering a potential therapeutic target for the stabilization of carotid plaques.MethodsThe immunohistochemical staining technique was employed to assess the expression levels of both PDGFR‐β and Caspase 3 in stable and vulnerable carotid plaques. Tunnel staining was utilized to quantify the apoptosis of carotid plaques. Live‐cell imaging was employed to observe endocytic motility, while cell apoptosis was evaluated through Propidium Iodide staining. In an in vivo experiment, ApoE−/− mice were administered a PTP1B inhibitor to investigate the impact of PTP1B on atherosclerosis.ResultsThe heightened expression of PDGFR‐β correlates with apoptosis in patients with vulnerable carotid plaques. At the subcellular level of VSMCs, PDGFR‐β plays a pivotal role in sustaining a balanced endocytosis system motility, regulated by the expression of Rab5, a key regulator of endocytic motility. And PTP1B modulates PDGFR‐β signaling via Rab5‐mediated endocytosis. Additionally, disrupted endocytic motility influences the interplay between endosomes and lysosomes, which is crucial for controlling PDGFR‐β trafficking. Elevated PTP1B expression induces cellular apoptosis and impedes migration and proliferation of carotid VSMCs. Ultimately, mice with PTP1B deficiency exhibit a reduction in atherosclerosis.ConclusionOur results illustrate that PTP1B induces disruption in endocytosis and apoptosis of VSMCs through the Rab5‐PDGFRβ pathway, suggesting a potential association with the heightened vulnerability of carotid plaques.
Breaking down abundance to understand conservation for small populations: A case study of North Atlantic right whales
Authors: Reed Joshua , Corkeron Peter , New Leslie , Harcourt Robert 
Published: November 2024

AbstractThe world is currently facing a biodiversity crisis and for many species, this is exacerbated by historic exploitation. Monitoring programs provide an integral tool to understand changes in abundance and the impact of threats informing conservation actions. However, measures of absolute abundance for management can be misleading, particularly when there is a biased sex ratio. Here we recommend focusing on the rate‐limiting cohort for management actions using the case of North Atlantic right whales. The North Atlantic right whale has a male‐biased sex ratio, with reproductively active females making up less than a fifth of the species. We highlight the importance of understanding and incorporating reproductive potential into management actions to provide species with the best chance of recovery.
Surrendering Noble Lies Where We Buried the Bodies: Formative Civic Education for Embodied Citizenship
Authors: Fraser‐Burgess Sheron , Higgins Chris 
Published: November 2024

AbstractTo enact democracy, which is to live in communication with difference, requires a formative process that involves an education of the whole person for and through civic life. Drawing on Charles Mills's theory of Herrenvolk ethics and Jonathan Lear's analysis of psychosocial lapses that ail us, Sheron Fraser‐Burgess and Chris Higgins pursue a critical, historiographical, and psychosocial reading of our failures to live up to this aspiration, offering (1) a critique of our tendency to saddle ourselves with a false choice between a homogenizing unity and a differentiated but fractured republic; (2) a demonstration of why we must eschew a thin universalism of principles and confront difference as embodied; (3) an argument from the ethics of risk against the urge to reify and compartmentalize difference; and (4) an evocation of how deep pluralism itself might serve as a unifying creed. Civic education is not a matter of informing but of forming and cultivating vision and values. In pursuing the credal deep pluralism that is required to do justice to the prospects and perils of our democracy‐in‐the‐making, the task of the formative educator may be more difficult; but by embracing this creed, teachers may inspire their students to do the same.
Estimating Demographic Parameters for Bearded Seals, Erignathus barbatus, in Alaska Using Close‐Kin Mark‐Recapture Methods
Authors: Taras Brian D. , Conn Paul B. , Bravington Mark V. , Kilian Andrzej , Lang Aimée R. , Bryan Anna , Stimmelmayr Raphaela , Quakenbush Lori 
Published: November 2024

ABSTRACTReliable estimates of population abundance and demographics are essential for managing harvested species. Ice‐associated phocids, “ice seals,” are a vital resource for subsistence‐dependent coastal Native communities in western and northern Alaska, USA. In 2012, the Beringia distinct population segment of the bearded seal, Erignathus barbatus nauticus, was listed as “threatened” under the US Endangered Species Act requiring greater scrutiny for management assessments. We sought to estimate requisite population parameters from harvested seals by using close‐kin mark‐recapture (CKMR) methods, the first such application for marine mammals. Samples from 1758 bearded seals harvested by Bering, Chukchi, and Beaufort Sea communities during 1998–2020 were genotyped, genetically sexed, and aged by tooth annuli. After rigorous quality control, kin relationships were established for 1484 seals including two parent–offspring pairs (POPs) and 25 potential second‐order kin pairs. Most of the second‐order kin were half‐sibling pairs (HSPs), but four were potential grandparent‐grandchild pairs (GGPs). There were no full sibling pairs, suggesting a lack of mate fidelity. Mitochondrial DNA analysis identified 17 potential HSPs as paternally related, providing substantial evidence of persistent heterogeneity in reproductive success among adult males. The statistical CKMR model incorporates probabilities associated with POPs, HSPs, and GGPs and assumes known ages and a stable population. Our top model accommodates heterogeneity in adult male breeding success and yields an abundance estimate of ~409,000 with a coefficient of variation (CV) = 0.35, which is substantially greater than the “non‐heterogeneity” model estimate of ~232,000 (CV = 0.21), an important difference for managing a harvested species. Using CKMR methods with harvested species provides estimates of abundance with the added opportunity to acquire information about adult survival, fecundity, and breeding success that could be applied to other species of concern, marine and terrestrial.