bluuebunny/crossref_metadata_2025_split huggingface dataset:
An overview of the non‐procedural treatment options for peripheral neuropathic pain
Authors: Zeldin Evan R. , Goddard Adam R. , Boyle Maxwell S. , Madathil Renee L. , Rosenvall Erick , Majithia Kajri A. , Morrison Eric J. 
Published: November 2024

AbstractPeripheral neuropathic pain is common in patients with peripheral nerve injury and can significantly impact both their function and quality of life. There is a wide variety of non‐interventional treatment approaches, including pharmacologic therapy, physical/occupational therapy, modalities (therapeutic, mechanical, thermal, etc.), psychology, and lifestyle modification. First line pharmacologic therapy for peripheral neuropathic pain includes gabapentinoids, tricyclic antidepressants, and serotonin‐norepinephrine reuptake inhibitors. Other classes of medications, such as topical treatments, opioids, and cannabinoids, have more limited usefulness in treatment but remain part of a treatment regimen. Physical and occupational therapy, psychological interventions, and lifestyle medicine are important adjuncts in the treatment and prevention of future peripheral neuropathic pain. The strength of the evidence supporting each intervention varies, with that for pharmacologic intervention being the strongest. A combination of these options tailored to the individual needs of the patient likely will result in the best treatment outcome for peripheral neuropathic pain.
High‐resolution perfusion imaging in rodents using pCASL at 9.4 T
Authors: Pires Monteiro Sara , Hirschler Lydiane , Barbier Emmanuel L. , Figueiredo Patricia , Shemesh Noam 
Published: November 2024

AbstractAdequate perfusion is critical for maintaining normal brain function and aberrations thereof are hallmarks of many diseases. Pseudo‐Continuous Arterial Spin Labeling (pCASL) MRI enables noninvasive quantitative perfusion mapping without contrast agent injection and with a higher signal‐to‐noise ratio (SNR) than alternative methods. Despite its great potential, pCASL remains challenging, unstable, and relatively low‐resolution in rodents – especially in mice – thereby limiting the investigation of perfusion properties in many transgenic or other relevant rodent models of disease. Here, we address this gap by developing a novel experimental setup for high‐resolution pCASL imaging in mice and combining it with the enhanced SNR of cryogenic probes. We show that our new experimental setup allows for optimal positioning of the carotids within the cryogenic coil, rendering labeling reproducible. With the proposed methodology, we managed to increase the spatial resolution of pCASL perfusion images by a factor of 15 in mice; a factor of 6 in rats is gained compared to the state of the art just by virtue of the cryogenic coil. We also show that the improved pCASL perfusion imaging allows much better delineation of specific brain areas, both in healthy animals as well as in rat and mouse models of stroke. Our results bode well for future high‐definition pCASL perfusion imaging in rodents.
Fatty acid composition evaluation of abdominal adipose tissue using chemical shiftencoded MRI: Association with diabetes
Authors: Liu Dingxia , Yin Minyan , Chen Jiejun , Fu Caixia , Schneider Manuel , Nickel Dominik , Yao Xiuzhong 
Published: November 2024

AbstractThis study investigated the association between the fatty acid composition of abdominal adipose tissue in NAFLD patients using chemical shift–encoded MRI and the development of insulin resistance and T2DM. We enrolled 231 subjects with NAFLD who underwent both abdominal magnetic resonance spectroscopy and chemical shift–encoded MRI: comprising of 49 T2DM patients and 182 subjects without. MRI‐ and MRS‐based liver fat fraction was measured from a circular region of interest on the right lobe of the liver. The abdominal fatty acid compositions were measured at the umbilical level with chemical shift‐encoded MRI. Bland‐Altman analysis, Student's t test, Mann–Whitney U test, and Spearman correlation analysis were performed. The logistic regression was applied to identify the independent factors for T2DM. Then, the predictive performance was assessed by Receiver operating characteristic curve analyses. An excellent agreement was found between liver fat fraction measured by MRS and MRI. (slope = 0.8; bias =‐0.92%). In, patients with T2DM revealed lower fractions of mono‐unsaturated fatty acid (Fmufa) (33.68 ± 10.62 vs 38.62 ± 12.21, P =.0089) and higher fractions of saturated fatty acid (Fsfa) (34.11 ± 9.746 vs 31.25 ± 8.66, P =.0351) of visceral fat tissue compared with patients without. BMI, HDL‐c, Fmufa and Fsfa of visceral fat were independent factors for T2DM. Furthermore, Fsfa‐S% was positively correlated with liver enzyme levels (P =.003 and 0.04). However, Fmufa‐V% was negatively correlated with fasting blood glucose, HbA1c and HOMA‐IR (P =.004, P =.001 and P =.03 respectively). Hence, the evaluation of fatty acid compositions of abdominal fat tissue using chemical shift–encoded MRI may have a predictive value for T2DM in patients with NAFLD.
Sex estimation by discriminant function analysis of long bones in prehistoric Southeast Asian populations
Authors: Nhoem Sophorn , Domett Kate 
Published: November 2024

AbstractBiological sex estimation is an integral part of reconstructing the biological profile of an individual in forensic anthropological and bioarchaeological contexts. Formulating population specific discriminant function equations for metric variables is vital for reconstructing biological sex of fragmentary skeletal remains. This study aimed to develop multivariable and univariable sectioning point sex estimation equations from long bones of prehistoric Thailand and Cambodia people dated from 4700 to 1450 BP. A total of 481 individuals (236 females and 245 males) with 997 long bone measurements were analyzed. Discriminant function analysis was used to analyze sexually dimorphic measurements from long bones of humeri (177 females and 183 males), femora (169 females and 178 males), and tibiae (139 females and 151 males). Stepwise and direct multivariable functions offered the highest accuracies of 97.3% for humeri, 97% for femora, and 96.7% for tibiae. Univariable functions indicated that the recommended measurements for use in sex estimations with high cross‐validation accuracies are the humeral epicondylar breadth (89.1%), femoral maximum head diameter (87.1%), and tibial midshaft circumference (88.3%). These equations are applicable for use in sex estimation for the specific prehistoric Southeast Asian populations to improve our understanding of the prehistoric demography. Further evaluation and validation of the equations are required to test whether these equations can also be applied to estimate biological sex of contemporary Southeast Asian populations.
On the Effect of Fibre Orientation and MWCNTs on the Strain‐Sensing Performance of TPU/PANI Electrospun Nanofibres
Authors: Khedewy Amira T. , Saleh Dalia I. , Shaker A. 
Published: November 2024

ABSTRACTThe increasing demand for flexible electromechanical devices with superior stretchability, durability, thermal stability and sensitivity has driven the development of new smart functional materials to replace conventional semiconductors. This study utilises combining electrospinning and in situ polymerisation to fabricate four types of thermoplastic polyurethane/polyaniline (TPU/PANI) nanofibrous membranes with varied fibre orientation and multiwalled carbon nanotubes (MWCNTs) incorporation. The combined effects of material composition and fibre alignment on strain‐sensing performance were systematically explored. All membranes exhibited stable, symmetric ohmic behaviour under strain, with current decreasing as strain increased. Remarkable repeatability and stability were observed in cyclic current–time tests. MWCNTs addition significantly enhanced conductivity, with aligned fibres further boosting performance. Gauge factor (GF) measurements revealed that aligned TPU/PANI mats had GFs of 7 (0%–18% strain) and 14.3 (18%–40%), while aligned TPU/MWCNTs/PANI mats had GFs of 5.2 (0%–13%) and 7.3 (13%–40%). Random TPU/PANI mats showed GFs of 13.9 (0%–11%) and 23.3 (11%–40%) and random TPU/MWCNTs/PANI mats had GFs of 13.9 (0%–19%) and 24.7 (19%–40%). Each configuration demonstrated suitability for specific applications, with random TPU/MWCNT/PANI mats exhibiting the best overall performance. This research provides critical insights into optimising flexible strain sensors by tuning both material composition and fibre orientation.
Transverse impact performance and finite element analysis of three‐dimensional woven tubular composite with different structures
Authors: Song Yao , Ouyang Yiwei , Chai Ying , Wang Jiaxuan , Liu Yang , Gong Xiaozhou 
Published: November 2024

AbstractIn this study, experiments combined with finite element analysis (FEA) were used to investigate the damage mechanism of transverse low‐velocity impacts on three‐dimensional woven tubular composites (3DWTC) with different structures. The damage morphology after impact was observed using three‐dimensional microscopy and scanning electron microscopy (SEM). Three mesoscale models were constructed based on the authentic structure of the 3DWTC. Additionally, the effects of the structure type on the impact resistance, stress distribution, and damage morphology of 3DWTC were studied. The impact resistance of the shallow cross‐linked (SCL) structure is the strongest, according to the data. The structure that resists impacts the least is the through orthogonal (TO) structure. The greater the straightness of the warps in the structure, the density of the weft, the volume fraction, the greater the cooperative load‐bearing capacity of the warps and wefts, and the greater the speed of stress propagation. The wefts and inner warps are subjected to tensile forces at the point of impact. The outer warps are subjected to compression. The stresses are distributed in a cross‐shaped pattern. The straightened warp and weft parts of the TO serve a key structural role in load‐bearing. The warps of the SCL and the shallow‐crossed curved joint (SCCJ) structure serve a key structural role in the load‐bearing capacity.Highlights
The impact resistance of 3DWTCs was investigated.
The tensile state, stress propagation rate of 3DWTC were analyzed using the mesoscale model.
The main load‐bearing components are revealed.
The differences in damage morphology of 3DWTCs are analyzed.
Bonding strength of short carbon fiber reinforced PA6 composites ultrasonic welding joints
Authors: Li Liu‐Kai , Zhang Ting‐Ting , Cui Yin‐Kui , Xing Yu , Liang Jian‐Guo 
Published: November 2024

AbstractShort carbon fiber composites have high specific modulus, high specific strength and excellent formability, which are suitable for short‐term and environmentally friendly ultrasonic welding. In this study, ultrasonic welding experiments were conducted on short carbon fiber reinforced PA6 composites using a servo‐driven non‐metallic ultrasonic welder. The weld specimens were analyzed for spot weld morphologies, interfacial bonding strength, failure modes and compressive shear fracture to establish the correlation between weld energy and weld quality. The results indicate that when the welding energy is 450 J, the short carbon fibers are interlaced at the interface, which has a pinning effect, thereby enhancing the joint strength reaching 2990 N, and the welding efficiency reaches 46%. Besides, the compressive shear section is divided into regions. The proportion of heat and area in different compressive shear regions are quantitatively analyzed, and the calculation model of joint strength is proposed. Meanwhile, the correlation between welding energy and its correlation, as well as three different shear failure modes, is obtained. This work is helpful for the optimization of carbon fiber reinforced thermoplastic (CFRTP) ultrasonic welding process parameters and the evaluation of joint strength.Highlights
A special fixture for ultrasonic welding was designed to optimize the welding energy process of ultrasonic welding CFRTP, and the properties of ultrasonic welded joints were analyzed. When the welding energy is 450 J, a high shear strength welded joint of 2990 N was successfully prepared.
The shear fracture of the welded joint was successfully obtained by designing a special clamp for compression shearing. The welding area was qualitatively divided according to the temperature measurement results of the interface center. In addition, the heat and area ratio of different zones in the compression‐shearing area under different welding energy were quantitatively analyzed, and the calculation model of joint strength was proposed. At the same time, the welding energy and its correlation, as well as three different shear failure modes were obtained.
The short fiber distribution characterization and pores effect on the joint's strength were analyzed. The appearance of porosity defects has a significant weakening effect on the welded joint.
Soybean yield is positively linked to organic matter, but planting date remains more influential
Authors: Malone Lindsay Chamberlain , Ruark Matthew D. , Vann Rachel Atwell , Singh Maninder P. , Ross W. Jeremy , Conley Shawn P. 
Published: November 2024

AbstractEstablishing connections between soil health indicators and crop performance will help ensure that tests recommended to farmers relate to outcomes of interest. This study assessed the relationship of soybean [Glycine max (L.) Merr] yield with three common soil health indicators: soil organic matter (SOM), permanganate oxidizable carbon (POXC), and autoclaved citrate extractable nitrogen (ACE‐N). These tests were assessed alongside other factors (soil test phosphorus, soil test potassium [STK], mapped clay, planting date, summer precipitation, and location). Soil samples were collected from 457 producer‐managed fields between 2019 and 2021 in Arkansas, Michigan, North Carolina, and Wisconsin. Planting date and yield were reported by producers, while mapped clay and rainfall were determined using publicly available data. Simple linear regression was used to assess the relationship between soil health indicators and yield: the natural log of SOM and POXC were positively associated with soybean yield (R2 = 0.07, p < 0.001; R2 = 0.03, p < 0.001), while ACE‐N was not (p = 0.872). Multiple linear regression was used to further test the relationship of SOM and POXC with yield, while accounting for other factors that contribute to soybean yield. Models explained 27% of variation in yield, with significant factors including SOM or POXC, soybean planting date, STK, and mapped clay. Based on standardized coefficients, planting date was the most influential factor associated with yield. Broadly, our results indicate that improvements in yield are linked to higher SOM, but management decisions like planting early are critical for achieving high yields.
On the Variation in Surface State of Nominally Identical Fused Silica Optics Surfaces
Authors: Seeling Sebastian , Köhler Robert , Tasche Daniel , Gerhard Christoph 
Published: November 2024

ABSTRACTA considerable number of different tools and operating materials are used in classical optics manufacturing. Moreover, further parameters such as environmental and process conditions contribute to material removal and surface smoothing in the course of production. A large potential variety of the final surface state of optics can thus be expected. Against this background, nominally identical fused silica optics surfaces purchased from different suppliers were investigated in the present work via x‐ray photoelectron spectroscopy, laser‐induced breakdown spectroscopy, infrared spectroscopy, ellipsometry, and atomic force microscopy. It is shown that the surfaces under consideration feature quite different types and degrees of contamination that can be attributed to the particularly used water and polishing agent. Moreover, slight differences in index of refraction and surface roughness were detected. The presented data thus confirm the expectation that the surface state of an optical component might depend on its origin. The findings are intended to sensitize users regarding such a potential impact, for example, when switching to other suppliers for bought‐in parts and outsourced precision optics items.
Synthesis and Molecular Docking Study of Hydrazone Schiff Bases of α‐Naphthalene‐Containing Alkyl Phenyl Ether Fragment as Potent α‐Amylase and α‐Glucosidase Inhibitors
Authors: Shah Tanzeela Ahmad , Alam Aftab , Zainab  , Assad Mohammad , Parveen Zahida , Rafiq Huma , Ayaz Muhammad , Shah Syed Adnan Ali , Latif Abdul , Ali Mumtaz , Ahmad Manzoor 
Published: November 2024

AbstractIn this study, new Schiff base derivatives of α‐naphthalene acetic acid containing alkyl phenyl ether fragment have been effectively synthesized through multistep reaction process, characterized by 1H‐NMR and 13C‐NMR spectroscopy. These derivatives have been tested for their in vitro α‐amylase and α‐glucosidase inhibitory activities. In the series, 8 compounds (2j, 2f, 2e, 2m, 2a, 2b, 2l, and 2c) exhibited promising α‐amylase inhibition with IC50 values from 5.38 ± 0.36 to 14.59 ± 0.64 µg/mL. Similarly, in the case of α‐glucosidase inhibitory activity, 10 derivatives (2e, 2f, 2j, 2m, 2b, 2c, 2i, 2d, 2a, and 2l) exhibited excellent activity having IC50 values from 6.96 ± 0.39 to 16.27 ± 0.31 µg/mL, wheras the remaining derivatives exhibited good‐to‐least antidiabetic potential. The ADME properties were calculated for all Schiff base derivatives using Swiss‐ADME web tool. Furthermore, the docking studies identified the binding modes of the compounds.
Ultrasound Guided Local Delivery of Bioorthogonal PDL1 Degrader for Enhanced Immunotherapy
Authors: Wang Lantian , Liu Zhaoyou , Ji Panpan , Ma Jiao , Mou Ke , Zhou Tian , Liang Yuan , Zhang Bin , Wei Mengying , Yang Guodong , Sun Wenqi , Gong Li , Yuan Lijun 
Published: November 2024

AbstractImmunotherapy involving PDL1 degradation holds great potential in anti‐tumor treatment. Optimal design of PDL1 degraders and subsequent efficient delivery into tumors are essential for expected efficacy, especially when abnormal tumor vasculature is considered. Herein, a nanodroplet‐based novel drug delivery platform termed as NDsmTx (nanodroplet‐based therapeutics) for ultrasound targeted delivery of PDL1 degrader is designed. Briefly, the shell of the NDsmTx is armed with RGD and mPD1 (a bioorthogonal PD1 mutant produced by genetic codon expansion technology can covalently bind PDL1), and the core is composed of perfluorohexane (PFH, C6F14). The RGD on the NDsmTx recognizes αvβ3 expressed by tumor vasculature, making NDsmTx accumulated in tumor practical and visible by low‐frequency ultrasound (LFUS). In turn, inertial cavitation induced by LFUS facilitates mPD1 on the nanodroplet debris penetrating the tumor, where mPD1 covalently binds PDL1 and initiates a lysosomal degradation process. Through both in vitro and in vivo study, the superior performance of NDsmTx in degrading PDL1 and boosting anti‐tumor immunity is confirmed. In conclusion, NDsmTx emerge as an alternative to existing PDL1 blockers in tumor immunotherapy.
Bioactive Peptide Hydrogel Scaffold with High Fluidity, Thermosensitivity, and Neurotropism in 3D Spatial Structure for Promoted Repair of Spinal Cord Injury
Authors: Sun Zhengang , Luan Xin , Sun Zhenjuan , Li Dagang , Hu Huiqiang , Xue Qingpei , Liu Bo , Yu Qianqian , Wei Gang , Zhang Xuanfen , Xi Yongming 
Published: November 2024

AbstractSpinal cord injury (SCI) has been considered a clinically challenging disease that is characterized by local disturbance of the microenvironment, which inhibits post‐injury neural regeneration. The simulation of a microenvironment conducive to the regeneration of spinal cord is beneficial for SCI repair. In this study, bioactive composite hydrogels are developed that mimic the regenerative microenvironment of spinal cord for enhanced SCI repair. The fabricated composite hydrogels (CRP) based on chitosan (CS), RADA16 nanofibers, and nerve‐promoted peptide (PPFLMLLKGSTR) exhibit excellent injectability, superior biodegradability and biocompatibility. In addition, the CRP hydrogels can form quickly (a few minutes) by mixing three components at human body temperature, showing high potential as a biomimetic matrix for in situ repair of SCI. The in vitro studies demonstrate that the CRP hydrogels can not only promote the proliferation and migration of bone marrow mesenchymal stem cells but also induce the proliferation and differentiation of neural stem cells (NSCs) into neurons. Meanwhile, the hydrogels reveal the efficiency of protecting neurons and promoting axonal growth. Furthermore, the in vivo tests prove that the CRP hydrogels can reduce post‐SCI inflammatory responses, inhibit reactive astrocyte over‐proliferation, and promote the migration, proliferation, and differentiation of endogenous NSCs, which agree well with the in vitro results. The pre‐clinical test demonstrates that the CRP hydrogels restore the motor function in completely transected spinal cord rats, and the SCI repair mechanism may involve the activation of the PI3K/AKT/mTOR pathway. It is believed that the strategies shown in this work will be valuable for the design and synthesis of novel hydrogels for biomedical and tissue engineering applications.
Characterization of a new barley greenbug resistance gene Rsg4 in the Chinese landrace CI 2458
Authors: Xu Xiangyang , Mornhinweg Dolores , Bai Guihua , Li Genqiao , Bian Ruolin , Bernardo Amy 
Published: November 2024

AbstractBarley (Hordeum vulgare) is a climate‐resilient crop widely cultivated in both highly productive and suboptimal agricultural systems, and its ability to adapt to multiple biotic and abiotic stresses has contributed significantly to food security. Greenbug is a destructive insect pest for global barley production, and new greenbug resistance genes are needed to overcome the challenges posed by diverse greenbug biotypes in fields. CI 2458 is a Chinese landrace exhibiting a unique resistance profile to a set of 14 greenbug biotypes, which suggests the presence of a new greenbug resistance gene in CI 2458. A recombinant inbred line population from the cross Weskan × CI 2458 was developed, evaluated for responses to greenbug biotype F, and genotyped using single nucleotide polymorphism (SNP) markers generated by genotyping‐by‐sequencing. Linkage analysis revealed a single gene, designated Rsg4, conditioning greenbug resistance in CI 2458. Rsg4 was delimited to a 1.14 Mb interval between SNP markers S3H_666512114 and S3H_667651446 in the terminal region of chromosome arm 3HL, with genetic distances of 1.2 cM proximal to S3H_667651446 and 1.1 cM distal to S3H_666512114. Allelism tests confirmed that Rsg4 is a new greenbug resistance gene independent of Rsg1 and Rsg3, which reside in the same chromosome arm. Rsg4 differs from Rsg1 alleles and Rsg3 in its resistance to greenbug biotype TX1, one of the most widely virulent biotypes. The introgression of Rsg4 into locally adapted barley cultivars is of agronomic importance, and kompetitive allele‐specific polymerase chain reaction (KASP) markers flanking Rsg4, KASP‐Rsg336‐1 and KASP‐Rsg336‐2, enable rapid pyramiding of Rsg4 with other resistance genes to develop durable greenbug‐resistant cultivars.