bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-Phase Solvent/Acid Deepwater Stimulation Treatment Proves to be Successful
Authors: Huval Wendy , Berard Kelly , Steckler Jason , Sanford Jack 
Published: August 2019

Abstract
A multi-phase stimulation treatment was required and subsequently executed in deep-water Gulf of Mexico to remediate a multitude of damage mechanisms resulting from years of hydrocarbon production. Among the many challenges that deep-water operators must face, there is the need for remediation of wells experiencing a decline in production. The execution of these treatments can prove to be very costly and require extensive damage assessments to properly design the most effective stimulation plan. Treatment placement is a major part of the decision process and will impact the performance of the job. A well in the Mississippi Canyon field had an asphaltene deposition issue based on asphaltene onset pressure evaluations as well as suspected fines migration issues. Each requiring its own treatment protocol. This operation required that a rig be moved onto location so that the job could be pumped via coiled tubing to assure injectivity into the zone of interest.
A multiphase approach design included:
Phase I -a screen/near wellbore soak
Phase II- a diverted specialty solvent formation treatment to remediate asphaltene deposition.
Phase III- a diverted mud acid treatment that included specialty stimulation systems to address scaling, clay and fines issues.
The challenge is the difference between utilizing xylene alone for organic deposition removal verses specialty solvent treatments specific to asphaltene removal as well as the use of deep penetrating hydrofluoric acid blends and specialty additive packages.
Utilizing this multi-phase approach resulted in a successful treatment outcome for the operator. An increase in total fluids production, an increase in flowing tubing and a job pay off of less than 30 days was the result of finding a solution to these particular set of challenges.
Association of joint awareness with satisfaction, knee function, and noise perception after total knee arthroplasty.
Authors: Taniguchi Hiroto , Itoh Masafumi , Yoshimoto Nobuyuki , Itou Junya , Kuwashima Umito , Okazaki Ken - 
Published: August 2019

Abstract
Background: Forgotten Joint Score-12 (FJS-12) measures the clinical outcomes focusing on joint awareness after surgery, such as total knee arthroplasty (TKA). The Knee Society Scoring System-2011 (KSS-2011) includes questionnaires for satisfaction, expectation, and functional activities. However, the relationship between FJS-12 and KSS-2011 has not been validated to our knowledge. In addition, some patients complain of noise after TKA. However, how the noise affects joint awareness and satisfaction has not been evaluated. The aim of this study is to clarify the relationship among FJS-12, KSS-2011 and the noise.
Methods: Using the FJS-12 and KSS-2011, 295 knees from 225 patients who underwent TKA was retrospectively evaluated. Noise perception was evaluated by a questionnaire with five grades which is a method that follows the questionnaire form of FJS-12 [“Are you aware of the noise of your artificial joint?” ; never, almost never, seldom, sometimes, mostly]. The correlations among FJS-12, KSS-2011, and noise were analyzed. In addition, patients were divided into four groups based on the mechanism of their implant [cruciate retaining, posterior stabilized, cruciate sacrificed, and bicruciate stabilized (BCS)]. FJS-12, KSS-2011, and noise were compared among the groups.
Results: A strong correlation was observed between FJS-12 and the total score of KSS-2011 (0.70; P < 0.001). FJS-12 also was correlated with KSS-2011 subcategories for “symptoms,” “satisfaction,” and “standard activities” that these correlation coefficients were approximately 0.60. Noise was limited to have weak correlations with FJS-12 (0.28; P < 0.001) and KSS-2011 (0.20 P < 0.001). With comparison among the TKA mechanisms, BCS showed significantly better KSS-2011 and greater range of movement but worse noise scores.
Conclusions: Joint awareness assessed by FJS-12 was correlated strongly with KSS-2011 and associated with satisfaction, residual symptoms, and daily activities as assessed by KSS-2011 subscores. Noise perception had limited effect on joint awareness and clinical outcomes.
miR-203 Inhibits Cell Proliferation and ERK Pathway in Prostate Cancer by Targeting IRS-1
Authors: Hu Xiaoyan , Li Shasha , Meng Yang , Zeng Xinyi , Qiu Lei , Wei Mingtian , Wang Ziqiang , Han Junhong 
Published: August 2019

Abstract
Background: Prostate cancer (PCa) is one of the most common types of cancer in men. In the course of the development and progression of this disease, abnormal expression of miR-203 is usually accompanied. However, its role in prostate tumorigenesis and the underlying mechanism are poorly understood.

Methods: Dual luciferase reporter gene analysis was used to detect miR-203 binding site in insulin receptor substrates 1 (IRS-1). Cell proliferation was assessed by MTT assay in PCa cells which either IRS-1 was knocked down by shRNA or miR-203 was overexpressed. IRS-1 and other proteins expression in PCa cells was assessed by Western Blot.

Results: we found that the insulin receptor substrates 1 (IRS-1) is a novel target of miR-203 in PCa and miR-203 can specially bind to the 3′UTR region of the IRS-1 thus suppresses its expression. Moreover, we demonstrate that miR-203 functions as a tumor suppressor by directly targeting IRS-1 to inhibit cell proliferation, migration and tumor angiogenesis which resulted in PCa cell cycle arrest. Importantly, miR-203 overexpression blocks ERK signaling pathway by down-regulating IRS-1 expression.

Conclusions: Our results show a novel link between miR-203 and IRS-1, and reveal the importance of strict control of IRS -1 by miR-203 in the progression of PCa, suggesting miR-203 may act as a promising target for the diagnosis and treatment of advanced PCa.

Keywords: Prostate cancer, miRNA, Insulin receptor substrates 1 (IRS-1), cell proliferation, ERK pathway
Remediation of bio-refinery wastewater containing organic and inorganic toxic pollutants by adsorption onto chitosan-based magnetic nanosorbent
Authors: Kumar Abiram Karanam Rathan , Saikia Kongkona , Neeraj Gerard , Cabana Hubert , Kumar Vaidyanathan Vinoth 
Published: August 2019

AbstractThe novelty of the current study deals with the application of magnetic nanosorbent, chitosan-coated magnetic nanoparticles (cMNPs), to be utilized for the management of lignocellulosic bio-refinery wastewater (LBW) containing three heavy metals and 26 phenolic compounds. The magnetic property of the adsorbent, confirmed by elemental and vibrating sample magnetometer analysis (saturation magnetization of 26.96 emu/g), allows easy separation of the particles in the presence of an external magnetic field. At pH 6.0, with optimized adsorbent dosage of 2.0 g/L and 90 min contact time, maximum removal of phenol (46.2%), copper (42.2%), chromium (18.7%) and arsenic (2.44%) was observed. The extent of removal of phenolic compounds was in the order: polysubstituted &gt; di-substituted &gt; mono-substituted &gt; cresol &gt; phenol. Overall, the adsorption capacity (qe) of cMNPs varies among the different contaminants in the following manner: copper (1.03 mg/g), chromium (0.20 mg/g), arsenic (0.04 mg/g) and phenol (0.56 mg/g). Post-adsorption, retrieving the cMNPs using an external magnetic field followed by single-step desorption via acid–base treatment is attractive for implementation in industrial settings. Reusability of the adsorbent was studied by recycling the cMNPs for five consecutive rounds of adsorption followed by desorption, at the end of which, cMNPs retained 20% of their initial adsorption capacity.
Auditor Choices during Event Log Building for Process Mining
Authors: Jans Mieke 
Published: August 2019

ABSTRACT
Applying process mining as an analytical procedure is a relatively young stream of thought in auditing. This paper examines the first step of such process-mining projects, which involves extracting and structuring the data in the required format for analysis. The article has a dual purpose: (1) to provide an overview of the choices to be made in this phase, and (2) to provide insights into the current event log preferences of auditors. These insights are valuable for a better understanding of how event logs are currently structured, along with the consequences of this structure for the analytical procedure. This matter is important because different preparation steps could lead to varying analytical procedures and consequently, to other audit evidence. This study also aims to reveal what data are perceived as most valuable to the auditor for further analysis. To address this goal, a case study has been conducted.
Analyst Contrarianism
Authors: Bozanic Zahn , Chen Jing , Jung Michael J. 
Published: August 2019

ABSTRACT
We examine a specific form of what we term analyst contrarianism. We define contrarianism as cases where an analyst expresses a summary opinion contrary to the direction of a given earnings surprise or revision. Distinct from analyst optimism or boldness, we document that analysts interpret negative (positive) earnings news in a positive (negative) light in approximately 11–15 percent of reports. We conjecture that some analysts look for opportunities to make a contrarian stock call for their clients in order to gain visibility, recognition, and career advancement. Our empirical evidence, which is supported by analyst interviews and content analysis of analyst reports, shows that: (1) analysts at non-top-tier brokerage houses are more likely to make a contrarian call, (2) analyst reports that contain contrarian opinions are associated with greater market reactions, and (3) contrarian analysts are more likely to exhibit career advancement.
JEL Classifications: G41; M41.
Protocol for evaluation of enhanced models of primary care in the management of stroke and other chronic disease (PRECISE)
Authors: Andrew Nadine E , Kim Joosup , Cadilhac Dominique A , Sundararajan Vijaya , Thrift Amanda G , Churilov Leonid , Lannin Natasha A , Srikanth Velandai , Kilkenny Monique F 
Published: August 2019

IntroductionThe growing burden of chronic diseases means some governments have been providing financial incentives for multidisciplinary care and self-management support delivered within primary care. Currently, population-based evaluations of the effectiveness of these policies are lacking.
AimTo outline the methodological approach for our study that is designed to evaluate the effectiveness (including cost) of primary care policies for chronic diseases in Australia using stroke as a case study.
MethodsPerson-level linkages will be undertaken between registrants from the Australian Stroke Clinical Registry (AuSCR) and (i) Government-held Medicare Australia claims data, to identify receipt or not of chronic disease management and care coordination primary care items; (ii) state government-held hospital data, to define outcomes; and (iii) government-held pharmaceutical and aged care claims data, to define covariates. N=1500 randomly selected AuSCR registrants will be sent surveys to obtain patient experience information. In Australia, unique identifiers are unavailable. Therefore, personal-identifiers will be submitted to government data linkage units. Researchers will merge the de-identified datasets for analysis using a project identifier. An economic evaluation will also be undertaken.
AnalysisThe index event will be the first stroke recorded in the AuSCR. Multivariable competing risks Poisson regression for multiple events, adjusted by a propensity score, will be used to test for differences in the rates of hospital presentations and medication adherence for different care (policy) types. Our estimated sample size of 25,000 patients will provide 80% estimated power (α >0.05) to detect a 6-8% difference in rates. The incremental costs per Quality-adjusted life years gained of community-based care following the acute event will be estimated from a health sector perspective.
ConclusionCompletion of this study will provide a novel and comprehensive evaluation of the effectiveness and cost-effectiveness of Australian primary care policies. Its success will enable us to highlight the value of data-linkage for this type of research.
Using deterministic record linkage to link ambulance and emergency department data: is it possible without patient identifiers?
Authors: Clark Sophie Jane , Halter Mary , Porter Alison , Smith Holly Christina , Brand Martin , Fothergill Rachael , Lindridge Jaqualine , McTigue Martin , Snooks Helen 
Published: August 2019

IntroductionRoutine linkage of emergency ambulance records with those from the emergency department is uncommon in the UK. Our study, known as the Pre-Hospital Emergency Department Data Linking Project (PHED Data), aimed to link records of all patients conveyed by a single emergency ambulance service to thirteen emergency departments in the UK from 2012-2016.
Objectives We aimed to examine the feasibility and resource requirements of collecting de-identified emergency department patient record data and, using a deterministic matching algorithm, linking it to ambulance service data.
Methods We used a learning log to record contacts and activities undertaken by the research team to achieve data linkage. We also conducted semi-structured interviews with information management/governance staff involved in the process.
Results We found that five steps were required for successful data linkage for each hospital trust. The total time taken to achieve linkage was a mean of 65 weeks. A total of 958,057 emergency department records were obtained and, of these, 81% were linked to a corresponding ambulance record. The match rate varied between hospital trusts (50%-94%). Staff expressed strong enthusiasm for data linkage. Barriers to successful linkage were mainly due to inconsistencies between and within acute trusts in the recording of two ambulance event identifiers (CAD and call sign). Further data cleaning was required on emergency department fields before full analysis could be conducted. Ensuring the data was not re-identifiable limited validation of the matching method.
Conclusion We conclude that deterministic record linkage based on the combination of two event identifiers (CAD and call sign) is possible. There is an appetite for data linkage in healthcare organisations but it is a slow process. Developments in standardising the recording of emergency department data are likely to improve the quality of the resultant linked dataset. This would further increase its value for providing evidence to support improvements in health care delivery.
Highlights

Ambulance records are rarely linked to other datasets; this study looks at the feasibility and resource requirement to use deterministic matching to link ambulance and emergency department data for patients conveyed by ambulance to the emergency department.
It is possible to link these data, with an average match rate of 81% across 13 emergency departments and one large ambulance trust.
All trusts approached provided match-able data and there was an appetite for data linkage; however, it was a long process taking an average of 65 weeks.
We conclude that deterministic matching using no patient identifiers can be used in this setting.
Hubungan antara Komunikasi Interpersonal dalam Keluarga dengan Kenakalan Remaja
Authors: Amalia Amalia , Natsir MHD 
Published: August 2019

Penelitian ini dilatarbelakangi oleh tingginya tingkat kenakalan remaja. Kenakalan remaja dapat mempengaruhi banyak faktor, salah satunya adalah kurangnya aplikasi komunikasi interpersonal keluarga. Diperkirakan ada hubungannya dengan komunikasi interpersonal dalam family. Penelitian ini untuk mendeskripsikan komunikasi interpersonal remaja pada keluarga, menggambarkan kenakalan, dan hubungan antara komunikasi interpersonal dalam keluarga dengan kenakalan remaja di Kampung Cimpu. Penelitian ini adalah tipe korelasional kuantitatif dengan 30 subjek penelitian yang sedang dipelajari siswa di SMAN 1 Sutera. Hasil penelitian ini dapat menunjukkan bahwa ada hubungan yang signifikan antara komunikasi interpersonal dalam keluarga dengan kenakalan remaja. Kata Kunci: Komunikasi Antarpribadi, Kenakalan Remaja
What Are the Client, Organisational and Employee-Related Outcomes of High Quality Leadership in the Allied Health Professions? A scoping review.
Authors: McKeever Janice , Brown Ted 
Published: August 2019

Background: Leadership is viewed as the panacea the complex problems in modern health care where chronic disease, contracting budgets and rising consumer expectation are challenging care provision. As the second largest workforce in Australia, Allied Health Professionals (AHP) are core contributors to health teams however they are largely absent from leadership positions and there is little evidence of their impact on client outcomes. Aim: A scoping review was carried out to synthesise evidence on the client, organisational and employee-related outcomes of high quality leadership in Allied Health. Method: A search of grey literature, peer and non-peer reviewed literature was undertaken using Embase, Emcare, SCOPUS and Psychinfo from 2010-2017. Data were sourced from journals, government reports, conference presentations and other grey literature. The reference list of key articles were hand searched for relevant research. Results: A total of 5880 articles were identified and after screening 35 articles were included for in depth review. Leadership contributed towards positive outcomes in all three domains and had influence across professional groups and services. Leaders are highly valued and respected by their teams. Allied Health leaders did not feature in any of the articles and AHP were the focus of only seven studies. The majority of articles were conference papers or case reviews that provided little robust data making it difficult to draw substantive conclusions on the outcome of AHP leadership. Conclusion: There was a lack of robust data specific to AHP leaders. Future research should attempt to gather evidence of the outcomes of AHP leadership through qualitative and quantitative means to substantiate the anecdotal evidence for high quality AHP leaders.
The Health Literacy Environment of a Regional Australian Elective Surgery Access Unit: consumer perspectives from pre-admission to post-discharge
Authors: Neil Sarah , Murphy Kylie , Chapman Glenda 
Published: August 2019

Background: Healthcare services should conscientiously ensure their health literacy environment (HLE) supports wayfinding, and provides comprehensible health information. Despite the increasing focus on the importance of evaluating and enhancing the HLE, consumer perspectives about HLE barriers and enablers have received limited attention in the published literature.
Objective: This study aimed to identify barriers and enablers in the HLE of the Elective Surgery Access Unit (ESAU) at Albury Wodonga Health in regional south-east Australia.
Methods:Three consumers participated in the study. Two of these participants completed a wayfinding interview, verbalizing the barriers and enablers encountered during wayfinding from the nearest carpark to the ESAU. All participants reviewed samples of written materials for ESAU consumers. Two participants, who had been discharged, commented on whether any important information was overlooked, from a post-discharge perspective. The data was categorized into inter-related themes within broader overarching domains.
Results:The helpfulness of the physical environment was one domain, involving three themes: signage, parking, and visual cues. The helpfulness of written information was another domain, involving three themes: comprehensiveness, readability and relevance. A third overlapping domain was: the importance of verbal information-giving. This domain also involved three themes: the importance of a phone number to seek assistance, a clearly identifiable reception area, and in-person communication.
Conclusions: The insights of these three service users can inform health services trying to enhance access for everyone needing healthcare. If more Australian health services reviewed their HLE, the findings could inform organizational improvements towards safer, more efficient, and higher quality healthcare.
A Practical Toolkit of Strategies for Building Research Capacity in Allied Health
Authors: Matus Janine , Wenke Rachel , Mickan Sharon 
Published: August 2019

Objectives: The objectives of this project were firstly to develop a practical toolkit of evidence-informed strategies for building research capacity in allied health, and secondly to disseminate and apply this toolkit to inform tailored research capacity building plans for allied health teams.
Design: This project used a plan, do, study, act (PDSA) service quality improvement methodology to develop, disseminate and apply a toolkit which was based on the results of a recent systematic review of allied health research capacity building frameworks and a narrative review of other interventions and theoretical recommendations.
Setting: Eight allied health professional teams in a publicly funded tertiary health service were supported to develop tailored research capacity building plans based on their specific needs, goals and context.
Main outcome measures: The outcomes of this project were evaluated using process measures including whether a research capacity building plan was developed and to what extent short-term goals were achieved within three months.
Results: A practical toolkit was developed which consolidates existing evidence-informed strategies and organises these around three components including ‘supporting clinicians in research’, ‘working together’ and ‘valuing research for excellence’ and 17 sub-components. Several barriers and facilitators to applying the toolkit to teams were identified and this paper suggests some recommendations and future directions for addressing these.
Conclusions: This toolkit may be a useful resource to inform the development of team-based research capacity building plans for allied health. The application of the toolkit may be enhanced by a needs assessment and facilitation from a researcher.
A Descriptive Analysis of a Health Management Work Integrated Learning Course: moving from Health Services Management learning to employment readiness
Authors: McConnell Duncan , Linwood Russell , Day Gary , Avery Mark 
Published: August 2019

Health Management Work Integrated Learning is a 40 credit point penultimate course of experiential learning in the Master of Advanced Health Services Management M(Adv)HSM now offered by the School of Medicine Health at Griffith University.
WIL was initiated in 2009 within the School of Public Health (Lilley et al (2009) based on a Teaching and Learning Grant to meet an existing experiential learning need identified for students studying in the enabling professional area of health management. After 15 semesters of delivery of these courses (completed at December 2016), it is timely to report on the quantitative attributes on the course to inform the post-graduate literature on this type of education. An objective of this review is to influence both curricula and student decision making regarding the future conduct and enhancement of tertiary preparation for health services management HSM employment. WIL has experienced a large increase in student enrolments in recent years suggesting that there is both strong demand for this nature of learning and student satisfaction with the quality of the learning modality in preparing for a career in HSM.