bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Strategi Pengembangan Zakat, Infaq, Shadaqoh dan Wakaf di Indonesia
Authors: Lubis Rusdi Hamka , Latifah Fitri Nur 
Published: July 2019

This study to describe the picture of ziswaf potential and Ziswaf's realization in Indonesia explained the difference between potential and realization. Beginning with a quantitative descriptive approach method by collecting secondary data from various sources. A very large gap between the value of potential and the amount of realization. During the last five years until 2016. The realization of zakat receipts was only less than 1%. The development of Ziswaf funds in Indonesia must have strategic objectives that must be reduced in the policies of all stakeholders. Thus, muzakki and mustahik are important components in the development and succession of empowerment. The selection of the right strategy can be done using the SWOT analysis method to produce a condition map of the research group and the right strategy to support the strategic objectives. The results of the analysis show that Ziswaf's condition in Indonesia has experienced and significant development. The results of the analysis also show that there are 6 (six) strategies that can be used to achieve Ziswaf's strategic objectives, namely: (1) digitizing of Ziswaf, (2) Islamic Inclusive Finance Council, (3) Database Development, (4) Regulation Implementation, (5) Zakat Automation, (6) Tax incentives for muzakki.
Integrative analysis of microRNA and mRNA expression in response to salt stress by UMI
Authors: Zhan Jing jing , Diao Yang yang , Zhao Yan yan , Li Chao , Han Xiao , Huang Long yu , sajjad muhammad , Wang Peng , Liu Li sen , Yan Qing di , Wei Xi , Ding Yan peng , Chu Yu , Ge xiao yang 
Published: July 2019

Abstract
Background

Small RNAs play an important role in regulating plant responses to abiotic stress through modulation of the processing, stability, and translation of larger RNAs. Plants employ complex mechanisms of gene regulation to respond to salinity stress.

Results

In this study, we constructed 12 small RNA libraries, 12 mRNA libraries, and a degradome library to systematically investigate the miRNAs response to salt stress. A total of 312 cotton miRNAs were identiﬁed and of these, 80 were known ghr-miRNAs. 144 genes showed significant differential expression under salt stress combined with the targeting relationship between the sRNA data and mRNA data. We found 56 miRNA-mRNA pairs which were positively correlated, and 91 pairs which were negatively correlated. Using degradome sequencing, 72 target genes were identified associated with 25 miRNA families. Gene ontology and KEGG analysis indicated some targets were involved in vital biological pathways of salinity stress tolerance: 14 were involved in responses to abiotic stress, two were associated with an environmental adaptation pathway, and a total of 16 NAC and MYB family transcription factors were related to salinity stress.

Conclusions

The present study identified a large number of cotton miRNAs and identified relationships between miRNA and mRNA, with function annotation revealing their possible biological roles in response to salt stress. Our findings will further functional studies of cotton miRNAs and the salt tolerance mechanism.
Efficacy of urination in alleviating urethral pain associated with flexible cystoscopy - a single-center randomized trial
Authors: Xie Yingwei , Wang Wei , Yan Wei , Liu Dan , Liu Yuexin 
Published: July 2019

Abstract
Objective: This study aimed to assess whether urethral pain can be alleviated by urination in male patients undergoing flexible cystoscopy.
Patient and Methods: Ninety-six male outpatients undergoing flexible cystoscopy were randomly divided into two groups. Patients in the test group urinated during flexible cystoscopy, whilst patients in the control group received no instructions to do so. All patients received 10mL of 2% lidocaine gel prior to assessment. Using 0 (no-pain) to 10 (unbearable severe pain) pain scores (VAS), we assessed patient discomfort prior to anesthesia gel perfusion (baseline), during gel perfusion, during cystoscope insertion through the urethra, and 15minutes post-examination analysis. The entire protocol was completed by a single doctor in our Department of Urology.
Results: The groups showed no statistical differences regarding age or examination time. During cystoscope insertion, the test group recorded significantly lower pain scores 2 (IQR 1-3) - compared to the control group 3 (IQR 2-3) , (P = 0.001). No significant differences between other evaluation points were observed between groups.
Conclusion: Urethral pain can be significantly alleviated by urination in male patients undergoing flexible cystoscopy through the urethra.
SUGAMMADEX ALWAYS FAST? PROBABLY YES, BUT IN LIVER TRANSPLANTATION
Authors: DEANA CRISTIAN , Barbariol Federico , D’Incà’ Stefano , Pompei Livia , Rocca Giorgio Della 
Published: July 2019

Abstract
Background: Rapid neuromuscular block reversal at the end of major abdominal surgery is recommended to avoid postoperative residual. To date, no study has evaluated sugammadex use and performance after rocuronium administration in patients undergoing liver transplantation. This is a randomized controlled trial with the primary objective of assessing the recovery time of neuromuscular transmission with sugammadex versus neostigmine after rocuronium administration in patients undergoing LTx. Methods The TOF-Watch SX® with calibration and linked to a portable computer with TOF-Watch SX Monitor Software® was used to monitor and record intraoperative neuromuscular block, maintained with a continuous infusion of rocuronium. Anaesthetic management was standardized as per our institution's internal protocol. At the end of surgery, neuromuscular moderate block reversal was obtained after administration of 2 mg/kg of sugammadex or 50 mcg/kg of neostigmine (plus 10 mcg/kg of atropine). Results: Data from 41 patients undergoing liver transplantation were analysed. In this population, neuromuscular block recovery time was faster after administration of sugammadex than neostigmine, with a mean value±SD of 9.4±4.6 min vs. 34.6±24.9 min respectively (p<0.0001).Conclusion: neuromuscular block reversal after rocuronium continuous infusion was significantly faster with sugammadex than neostigmine and feasible in patients undergoing liver transplantation. It is important to note that sugammadex recovery time in this population was found to be considerably longer than in other surgical settings, an interesting finding that needs further studies to be fully explained and it should be taken into consideration in clinical practice.Trial registration: ClinicalTrials.gov NCT02697929.Keywords: rocuronium, neostigmine, reversal, recovery time, liver transplantation.
Addition of haloperidol to ondansetron and dexamethasone to prevent postoperative nausea and vomiting in female smoking patients following laparoscopic surgery: A prospective, randomized, double-blind study
Authors: Zhuang Xin-qi , Yang Ji , Zhao Sen , Lu Yue-chun , Xie Ke-liang , Yu Yong-hao 
Published: July 2019

Abstract
Background

Postoperative nausea and vomiting (PONV) is an unpleasant experience that impacts on patient comfort and satisfaction and may lead to other complications. Some risk factors such as female gender and non-smoking status were used to predict the risk of PONV. Regarding its prevention, the combination of two different types of prophylaxis has been demonstrated to exert an additive effect. The present study aimed to evaluate the efficacy of a triple combination of haloperidol, ondansetron and dexamethasone for the prevention of PONV following laparoscopic gynecological surgery in female smoking patients.

Methods

A total of 210 eligible consecutive female patients ranked as American Society of Anesthesiology physical status I-II and aged 18-60 years who were undergoing selective laparoscopic gynecological surgery were included in the current study and allocated into three groups: Patients in group O received 4 mg ondansetron, group OD received 4 mg ondansetron and 8 mg dexamethasone, group ODH received 4 mg ondansetron, 8 mg dexamethasone and 2 mg haloperidol intravenously prior to anesthesia induction. The incidence of PONV, the need for rescue antiemetics, pain score, patient-controlled analgesia (PCA) consumption, rescue analgesics and adverse events were recorded 48 h after operation.

Results

The final analysis consisted of 193 patients who completed the study. Results indicated that the incidence of PONV was significantly decreased in groups OD (20.00%) and ODH (15.63%) compared with in group O (42.19%; P = 0.005). Furthermore, the need for rescue antiemetics was significantly lower in groups OD (13.85%) and ODH (12.50%) than in group O (32.81%; P = 0.005). There was no significant difference in the incidence of PONV or the need for rescue antiemetics between groups OD and ODH (P = 0.516 and 0.821 respectively). No statistically significant differences were detected in pain score, PCA consumption, rescue analgesics or adverse events among the groups (all P > 0.05).

Conclusion

The addition of haloperidol to a combination of ondansetron and dexamethasone did not decrease PONV frequency below that obtained with the two-drug combination. As for female smokers, prophylaxis comprising ondansetron and dexamethasone, with or without haloperidol, could effectively reduce PONV following laparoscopic surgery.
Comparison Efficacy of Bacterial and Fungal Probiotics on Acute Pediatric Diarrhea A Randomized Clinical Trial
Authors: Sharif Alireza , Ardakani Abbas Taghavi , Kashani Hamed Haddad , Rabiee Fatemeh , Sharif Mohammad Reza 
Published: July 2019

Abstract
Background

Diarrheal disease is one of the leading causes of mortality and morbidity in developing countries. Probiotics, recognized as living microorganisms, are known to balance human intestinal flora. Many studies have shown that probiotics can be used as an alternative treatment to acute diarrhea. This study was designed to evaluate the effects of fungal and bacterial probiotics on acute pediatric diarrhea.

Methods

This clinical trial was conducted on 90 children aged 2 to 5 years, who were referred to the Kashan Children's Hospital, Iran, in 2015 for complaints of acute watery diarrhea and were treated on an outpatient basis. These children were randomly divided into three groups of 30. The first group received a standard daily treatment with ORS plus bacterial probiotics as a Kidilact® sachet containing 7 strains of Lactobacillus strains; the second group received ORS and fungal probiotics containing Saccharomyces boulardii as Ardeypharm Yomogi® capsule, 250 mg once a day and the third group used placebo along with standard oral rehydration therapy. The duration of treatment with probiotics or placebo was 5 days.

Results

The current study showed no significant differences in age, gender, frequency and duration of diarrhea between the three groups before admission. The mean duration of diarrhea from onset of treatment to recovery was 2.80 days in the first group (bacterial probiotics), 3.17 days in the second group (fungal probiotics), and 4.43 days in the third group (placebo). A significant difference was observed in the duration of diarrhea after treatment between the three groups (P ≤ 0.05), so that the best effect was found in reducing the duration of diarrhea in the bacterial probiotic group, and the lowest effect was associated with the placebo group.

Conclusion

The use of probiotics in acute diarrhea in children could be effective in shortening the duration of diarrhea; however, the results of this study indicate that bacterial probiotics may seems to be superior to fungi but statistically does not have significant differences.
Trans-rectal natural orifice specimen extraction (NOSE) during laparoscopic anterior resection: Chinese experience with a novel method
Authors: Zhou Zhu-Qing , Wang Kai-Jing , Du Tao , Gao Wei , Zhu Zhe , Jiang Qixin , Ji Fang , Li Dan , Zhang Yuanyuan , Fu Chuan-Gang 
Published: July 2019

Abstract
Background: To introduce a novel method for double stapling technique in colorectal anastomosis during laparoscopic anterior resection of upper rectal or sigmoid colon cancer with trans-rectal natural orifice specimen extraction (NOSE). Methods: From June 2015 and May 2016, patients with upper-rectal or sigmoid colon cancer who received treatment in Shanghai East Hospital were enrolled. Preoperative and postoperative clinical variables were analyzed and compared between groups. Postoperative pain was analyzed utilizing a visual analog scale (VAS). Postoperative overall survival was analyzed using a K-M curve. Results: A total of 99 colorectal cancer cases were randomly divided into NOSE with novel method group (NOSE, n=48) and conventional laparoscopic group (non-NOSE, n=51). No statistically significant differences in preoperative demographics of the patients as sex, age, body mass index were found among the groups. The NOSE group had the longer operation time, but less blood loss than the non-NOSE group. The NOSE group had no abdominal incision and the lower postoperative VAS score. The time for intestinal function recovery and the length of hospital stay (LOS) was statistically significantly different, with the non-NOSE group having the longer time. The incidence of postoperative complications was lower in NOSE group (5/48, 10.4%) than in the non-NOSE group (8/51, 15.7%), the difference was statistically significant. The K-M survival curve showed no statistically significant difference in the disease free survival rate between the NOSE group and non-NOSE group. Conclusion: NOSE with novel method is safe and feasible to use in patients having colorectal cancer. Compared with traditional laparoscopic surgery, the postoperative complication rates of NOSE surgery were lower with an improved short-term clinical recovery.
Busulfan systemic exposure and its relationship with efficacy and safety in hematopoietic stem cell transplantation in children: A Meta-Analysis
Authors: Feng Xinying , Zhao Libo , Wu Yunjiao , Zhang Jingru , Li Jiapeng , Yang Chang qing , Zhu Guanghua , FAN Duanfang 
Published: July 2019

Abstract
Background

Busulfan (Bu) is a key component of several conditioning regimens used before hematopoietic stem cell transplantation (HSCT). However,the optimum systemic exposure (expressed as the area under the concentration-time curve [AUC]) of Bu for clinical outcome in children is controversial.

Methods

Research on pertinent literature was carried out at PubMed, EMBASE, ClinicalTrials.gov and the Cochrane Library. Observational studies were included, which compared clinical outcomes above and below the area under the concentration-time curve (AUC) cut-off value, which we set as 800, 900, 1000, 1125, 1350, and 1500 µM × min. The primary efficacy outcome was notable in the rate of graft failure. In the safety outcomes, incidents of veno-occlusive disease (VOD) were recorded, as well as other adverse events.

Results

Thirteen studies involving 548 pediatric patients (aged 0.3-18 years) were included. Pooled results showed that, compared with the mean Bu AUC (i.e., the average value of AUC measured multiple times for each patient) of > 900 µM × min, the mean AUC value of <900 µM × min significantly increased the incidence of graft failure (RR=3.049, 95% CI: 1.285-7.234). The incidence of VOD was significantly decreased with the mean AUC <1350 µM × min (RR=0.370, 95% CI: 0.205-0.666) and <1500 µM × min(RR=0.409, 95% CI: 0182-0.920).

Conclusions

In children, Bu the mean AUC of 900 µM × min should be considered the lowest threshold associated with its effective prevention of graft failure, while the mean AUC of >1350 µM × min is associated with increased VOD, particularly for the patients not undergoing VOD prophylaxis therapy.
Organizational issues of glaucoma diagnosis in Kazakhstan
Authors: Aldasheva Neilya , Tashtitova Lyailya , Kulmaganbetov Mukhit 
Published: July 2019

Abstract
Purpose

Analysis of the organizational issues of the diagnosis of glaucoma in Kazakhstan and State programs for health care system: “Salamatty Kazakhstan” and “Densaulyk”.

Methods

The state of screening for glaucoma was included increased intraocular pressure (IOP) measurement and pachymetry, which was used for the corneal thickness examination. Although the IOP can be increased or be in the normal ranges, thin central cornea thickness generally was ignored by ophthalmologists. In this regard, the indications for examination for glaucoma with systemic hypotension during screening were expanded, and pachymetry was one of the essential diagnostic tool in the clinical guideline for the diagnosis and treatment of glaucoma as a mandatory research method.

Results

Sufficiency and effectiveness of the screening program was confirmed by the trend in the number of identified patients with glaucoma depending on age. Correlation between suspected glaucoma and age groups was exposed.

The number of registered glaucoma patients was 43,337 patients in 2010. In contrast, after the screening program the figures raised to 68,195 people in 2016. Moreover, there was the increase of newly identified glaucoma cases by 49%: from 70.8 per 100 thousand populations in 2010 to 124 per 100 thousand populations in 2016.

Conclusions

State programs for health care system development in Republic of Kazakhstan "Salamatty Kazakhstan" (2011-2015) and "Densaulyk" (2016 – 2019) were the initial steps for the prevention of the irreversible blindness and disability due to glaucoma. Screening programs allow to timely and adequate diagnosis of the disease over 40 years of age.
Risk factors for periprosthetic joint infection after total knee arthroplasty in Spanish population
Authors: Melchor Francisco , Pescador David , Mendoza Jose , Diaz Agustin , Soler Agustin , Blanco Juan 
Published: July 2019

Abstract
Background: Periprosthetic joint infection (PJI) is the most serious and feared complication in total knee arthroplasty (TKA) and can have catastrophic consequences. The number of total knee arthroplasties has increased and will continue to increase so that the number of infections will also be greater in the future. The aim of this study is to identify the most relevant risk factors associated with infection after a total knee prosthesis in a Spanish population.
Methods: This is a case-control study of patients who underwent total knee arthroplasty at the University Hospital of Salamanca during the period January 1 2010 until January 1, 2015. TKA PJI was detected in 66 patients. As controls, a similar number of patients from the same period who did not develop a periprosthetic infection were included. Demographic and clinical variables were collected. A descriptive and inferential analysis was performed.
Results: Diabetes, ASA grade, obesity and the use or not of antibiotic loaded cement were statistically significant related to the appearance of the infection. For the variables of surgical time and ischemia time, this relationship disappeared when the logistic regression was made.
Conclusions: Our study provides evidence that diabetes, cement type, ASA and BMI were independently associated with increased risk of PJI for TKA patients in a Spanish population. We think that modifiable risk factors were specifically relevant and for that reason we can reduce the infection rate.
Differentiation of mediastinal metastatic lymph nodes in NSCLC based on radiomic features of different phase CT imaging
Authors: Sha Xue , Gong Guan Zhong , Qiu Qing Tao , Duan Jing Hao , Li Deng Wang , Yin Yong 
Published: July 2019

Abstract
Background To develop radiomic models based on different phases of computed tomography (CT) imaging and investigate the efficacy of models to diagnose mediastinal metastatic lymph nodes in non-small cell lung cancer (NSCLC).Methods We selected 231 mediastinal lymph nodes confirmed by pathology results as the subjects, which were divided into training (n=163) and validation cohorts (n=68). The regions of interest (ROIs) were delineated on CT scans of the plain phase, arterial phase and venous phase, respectively. Radiomic features were extracted from the CT images of each phase. Least absolute shrinkage and selection operator (LASSO) was used to select features, and multivariate logistic regression analysis was used to build models. We constructed six models (orders of 1-6) based on radiomic features of the single- and dual-phase CT images. The performance of the radiomic model was evaluated by the area under the receiver operating characteristic curve (AUC), sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV).Results A total of 846 features were extracted from each ROI, and 10, 9, 5, 2, 2, and 9 features were chosen to develop models 1-6. All of the models showed superior differentiation, with AUCs greater than 0.8. The plain CT radiomic model, model 1, yielded the highest AUC, specificity, accuracy and PPV, which were 0.926 VS 0.925, 0.860 VS 0.769, 0.871 VS 0.882 and 0.906 VS 0.870 in the training and validation sets, respectively. When the plain and venous phase CT radiomic features were combined with the arterial phase CT images, the sensitivity increased from 0.879, 0.919 to 0.949, 0979 and the NPV increased from 0.821, 0.789 to 0.878, 0.900 in the training group, respectively.Conclusion CT radiomic models based on different phases all showed high accuracy and precision in the diagnosis of LNM in NSCLC patients. When combined with arterial phase CT, the sensitivity and NPV of the model can be further improved.
Patient Centred Medical Home (PCMH) transitions in western Sydney, Australia: A qualitative study
Authors: Metusela Christine , Usherwood Tim , Lawson Kenny , Angus Lisa , Kmet Walter , Ferdousi Shahana , Reath Jennifer 
Published: July 2019

Abstract
Objectives

Patient Centred Medical Homes (PCMHs), increasingly evidenced to provide high quality primary care, are new to Australia. To learn how this promising new healthcare model works in an Australian setting we explored experiences of healthcare providers in outer urban Sydney, where a number of practices are transitioning from traditional Australian general practice models to incorporate elements of PCMH approaches.

Design

We collected qualitative data from semi-structured interviews with healthcare providers working in a range of transitioning practices and thematically analysed the data.

Setting and participants

We interviewed 35 participants including general practitioners, practice managers and practice nurses from 25 purposively sampled general practices in western Sydney, Australia, seeking maximal variation in practice size, patient demographics and approaches to PCMH transitions.

Results

Interviewees described PCMH transformation highlighting the importance of whole of practice engagement with a shared vision; key strategies for transformation to PCMH models of care including leadership, training and supportive information technology; structures and processes required to provide team-based, data-driven care and constraints such as lack of space and the current Australian fee-for-service general practice funding model. They also reported early outcomes of the PCMH model of care, in particular enhanced patient and staff satisfaction and fewer hospital admissions which were described as likely to reduce the costs of care.

Conclusions

Our study exploring the experience of early adopters of PCMH models of care in Australia, informs the international movement towards PCMH Primary Health Care approaches. Our findings provide guidance for practices considering similar transitions and describe the challenges of such transitions within a fee-for-service payment system.