bluuebunny/crossref_metadata_2025_split huggingface dataset:
El hidalgo pobre en la poesía satírico-burlesca de Alonso de Castillo Solórzano (Donaires del Parnaso, I, núms. 48 y 49)The Poor Hidalgo in the Comic Poetry of Alonso de Castillo Solórzano (Donaires del Parnaso, I, no. 48 & 49)
Authors: Mansilla Fernando Rodríguez 
Published: May 2019

AbstractThis article explores the character of the impoverished hidalgo within the courtly culture of seventeenth century Spain. Through close reading, I analyze two poems of the first part of Donaires del Parnaso (1624), a comic poetry collection by Alonso de Castillo Solórzano. While the first poem mocks the hidalgo, the second one constitutes the reply of the character to the jokes against him. I read these texts in the context of the literary academy, which influences in the meaning of the verses. Lastly, I support my interpretations on other contemporary literary texts in order to determine the poems’ motifs and ideological purposes.
The Passionate Self and the Religiosity of Phenomena
Authors: Murchadha Felix Ó 
Published: May 2019

ABSTRACT
There are no religious phenomena, only religious interpretations of phenomena. But while the religious interpretation of phenomena refers to a particular form of human activity, this activity responds paradoxically to the imposition of a fundamental curb on any possible activity. That curb is encountered to the extent to which the religious hermeneutic imposes itself in the event of the appearance itself. In this sense the religious structure of experience is that which appears affectively and contingently as beyond the power of the self to regulate. In exploring the place of the self with respect to the religious phenomenon, this article explores the place of the self in its capacity and incapacity with respect to phenomenal objects. In working through this understanding of the self, the irreducible affectivity of the self's constitutive relations—specifically with respect to love, hope, awe, and anxiety—is discussed. As an affectively constituted being, the self recognizes itself as subject to an irreducibly foreign origin and destiny. In examining this position of a “passionate self” the article concludes with a phenomenology of fortune and contingency, which it is argued is fundamental to any understanding of the religious phenomenon.
Spirituality as Consummatory Experience: The Promises and Limitations of John Dewey's Phenomenology of the Religious
Authors: Weidenbaum Jonathan 
Published: May 2019

ABSTRACT
The mission of this article is to unpack Dewey's phenomenology of religious experience as it is found in both A Common Faith and Art as Experience, and to outline its promises and limitations. After first piecing together Dewey's position on the nature and constitution of religious experiences, I explore the question of whether or not a Deweyan phenomenology can assimilate or account for some of the most forceful and intense sorts of spiritual intuition as described by several philosophers of religion. William James, Rudolf Otto, and Emmanuel Levinas are among the figures discussed.
Good Governance and Integrity: Academic Institution Perspective
Authors: Nafi Norhazma Binti , Kamaluddin Amrizah 
Published: May 2019

Integrity is one of the moral principles related to moral uprightness. Recently, there are a lot of issues discussed regarding the integrity in public sector administration especially in public sector. Currently governance in public administration has been exposed to public criticism due to the governance failure, fraud, corruption and poor internal control. The purpose of the study is to examine the relationship between factors of good governance and the practice of integrity in academic institution. The factors of good governance include ethical leadership, financial resources and asset management. The study was carried out by using questionnaire and simple random sampling was chosen. The questionnaire survey was distributed to 98 academics from two academic institutions in Malaysia. Such sample was chosen since this study was focused on the academic’s perspective on integrity practice in academic institutions and none of the research has been done in term of good governance and integrity in academic institutions Malaysia. This study found that all three factors of good governance which are ethical leadership, financial resources and asset management have significant relationship on integrity practice in academic institution. The findings of this study can assist academic institutions in Malaysia to improve their governance system and also code of ethics in their organization. In order to improve future studies, it is recommended that the data collection made to be more extensive. This can help in observing the variation of practice of good governance and integrity in academic institutions.
The Design and Implementation of a Mathematics Learning Community
Authors: Kurepa Alexandra 
Published: May 2019

We describe the design and implementation of the Mathematics Learning Community structured as a cohort-based and faculty-mentored group composed mostly of underrepresented minority students in mathematics. The Mathematics Learning Community’s goals are: (i) to increase the number students majo National Science Foundation grant award ring in mathematics at both the undergraduate and graduate levels, (ii) to improve the retention and completion rates, and (iii) to increase the number of students pursuing advanced degrees in mathematics. The design is innovative in a number of ways including its focus on a single discipline, its inclusion of both graduate and undergraduate students in the same learning community, and the use of student vertical tutoring, and faculty mentoring, among other things. The inclusion of upper-level students appears to have reduced the unintended negative effects of typical student-centered learning communities. Although, the program is relatively new, the Mathematics Learning Community has been successful by a number of different measures.
Jeugdhulpverlening ‘met zachte drang’: duidelijkheid vereist
Authors: Verkroost D.S. 
Published: May 2019

Jeugdhulpverlening ‘met zachte drang’: duidelijkheid vereist
Binnen de jeugdhulpverlening is een kader ontstaan waarbinnen gezinnen bewogen worden om ‘vrijwillig’ mee te werken aan de hulpverlening. Dit ‘drangkader’ is niet wettelijk geregeld, met onduidelijkheden over de rechten, plichten en verantwoordelijkheden van betrokkenen tot gevolg. Dit artikel geeft de huidige stand van zaken weer.
Invasive Fungal Infections While on Voriconazole, Liposomal Amphotericin B, or Micafungin for Antifungal Prophylaxis in Pediatric Stem Cell Transplant Patients
Authors: Bui Annie , Nguyen Veronica , Hsu Christina , Hyde Ben , Simms-Waldrip Tiffany 
Published: May 2019

OBJECTIVE This study aimed to report the incidence of invasive fungal infections (IFIs) in pediatric hematopoietic stem cell transplant (HSCT) patients who received voriconazole, liposomal amphotericin B (L-AMB), or micafungin for primary antifungal prophylaxis (PAP).METHODS Using data retrospectively collected from institution's electronic records, this study analyzed the incidence of IFIs in pediatric HSCT patients between November 2012 and November 2016.RESULTS A total of 103 patients were screened. Of the 84 patients who met inclusion criteria, 76.2%, 29.8%, and 19% patients received voriconazole, L-AMB, and micafungin, respectively. The incidence of overall IFIs was 2.08 per 1000 prophylaxis days. There were 2 mold infections identified in 2 patients. Among 3 antifungal agents, the rates of IFIs were 2.67 per 1000 prophylaxis days in L-AMB group, 2.08 per 1000 prophylaxis days in micafungin group, and 1.17 per 1000 prophylaxis days in voriconazole group.CONCLUSION Patients who received L-AMB or micafungin had higher rates of IFIs than those who received voriconazole for PAP.
Dexmedetomidine for the Management of Postoperative Pain and Sedation in Newborns
Authors: Sellas Maria N. , Kyllonen Kay C. , Lepak Maryjoy R. , Rodriguez Ricardo J. 
Published: May 2019

BACKGROUND Opioids and benzodiazepines have been the mainstay of neonatal analgesia and sedation. However, based on evidence in neonatal animals, these drugs may be deleterious for the developing brain. Dexmedetomidine (DEX), a central alpha-2 agonist, has sedative and analgesic effects and has been shown to be neuroprotective in animal models. Despite increasing use of DEX in newborns, there is a paucity of data regarding its safety and efficacy in this population.
OBJECTIVES The impact of using DEX in postsurgical neonates, either alone or with opioid infusions, for sedation/analgesia was evaluated. The cumulative dose of opioids among patients who did or did not receive DEX was calculated to examine the hypothesis that the addition of DEX can reduce the patient exposure to opioids without significantly increasing side effects and providing adequate sedation and pain control.
METHODOLOGY This was a retrospective cohort study in which patients were matched by postnatal age and surgical procedure into 2 groups. One group received DEX in the regimen for treatment of pain or sedation after a surgical procedure, and the other group received no DEX. Episodes of bradycardia, respiratory depression and hypotension, and the cumulative dose of opioids and number of supplemental doses administered in both groups were documented.
RESULTS Although there was no difference in gestational age or weight at birth between the DEX and no-DEX groups, the DEX group's median postconceptional date was older at the time of surgery (39.6 vs 37.4 weeks; p = 0.003). Patients in the DEX group experienced more episodes of bradycardia (12.8% vs 5.1%; p = 0.01). There was no difference between groups in episodes of hypotension or respiratory depression. The cumulative dose of opioids was significantly lower in the DEX group compared with the no-DEX group (1155 mcg/kg vs 1841 mcg/kg; p = 0.01). There was no difference in the number of supplemental doses of opioids given between the groups.
CONCLUSIONS The addition of DEX to opioid infusions resulted in a significant decrease in the cumulative dose of opioids but was associated with more episodes of bradycardia than opioids alone.
A Retrospective Review of Antipsychotic Medications Administered to Psychiatric Patients in a Tertiary Care Pediatric Emergency Department
Authors: Rudolf Frances , Hollenbach Kathryn , Carstairs Keri L. , Carstairs Shaun D. 
Published: May 2019

OBJECTIVES An increasing number of pediatric patients with psychiatric chief complaints present to emergency departments (EDs) nationwide. Many of these patients require treatment with antipsychotic medications to treat agitation. We sought to examine the use of antipsychotic medications in pediatric patients presenting to a tertiary care pediatric ED.
METHODS We performed a retrospective electronic medical record review of patients presenting to a tertiary care pediatric hospital from January 2009 through February 2016 with a psychiatric chief complaint who received an antipsychotic medication in the ED.
RESULTS A total of 229 patients were identified, 54.1% of whom were male. Mean age was 14.4 ± 2.6 years. Commonly administered medications included olanzapine (51.1%), aripiprazole (26.6%), haloperidol (24.0%), and risperidone (11.8%). Eighty-seven patients (38.0%) were given at least 1 intravenous or intramuscular dose of antipsychotic medication. A total of 113 patients (49.3%) received only 1 antipsychotic medication, 65 (28.4%) received 2, 30 (13.1%) received 3, and 21 (9.2%) received 4 or more antipsychotics. Median length of stay (minutes) increased significantly with increasing number of medications administered (p &lt; 0.001). Length of stay was significantly shorter in patients given only oral medications (675.6 minutes, IQR 418–1194) compared to those given at least one intramuscular or intravenous dose (951 minutes, IQR 454–1652) (p = 0.014).
CONCLUSIONS In this retrospective series, the majority of patients were treated with newer oral antipsychotics. Administration of multiple medications was associated with a significantly longer length of stay in the ED, as was parenteral administration of antipsychotics.
¿Cómo mejorar el muestreo en estudios de porte medio usando diseños con métodos mixtos? Aportes desde el campo de estudio de elites
Authors: Serna Miguel 
Published: May 2019

El objetivo del trabajo es abordar algunas problemáticas recurrentes y alternativas para el diseño muestral de poblaciones de porte medio en el campo de estudio de elites.El trabajo parte de la problemática clásica de la fundamentación de los dos grandes tipos paradigmas teóricos-metodológico de muestreo, el cualitativo y el cuantitativo, revisión somera que tiene como meta mostrar la existencia de un zona de estudios de muestras de porte medio (entre 90 y 300-390 casos) donde las fronteras entre ambos se hace borrosa y por tanto es pertinente discutir la posibilidad de uso de muestro con métodos mixtos. A continuación se presenta el campo de estudio de las elites como un área fértil para el desarrollo de métodos mixtos y en particular en el procedimiento de muestreo.Por último se describen algunos aportes desde la experiencia y práctica de investigación en el campo de las elites políticas y económicas para resolver y buscar alternativas de mejora de las muestras en poblaciones de mediano porte, a saber: a) la explicitación de criterios objetivos en la construcción empírica del objeto de estudio, b) la aplicación de juicio de expertos para la validación de la muestra, c) el uso de pares expertos como instrumento de investigación.The purpose of the article is to address some recurrent and alternative problems for the sample design of medium-sized populations in the field of elite studies.The paper starts from the classical debate of the two great types of sampling based on the qualitative and quantitative methodological-paradigms. A brief review aims to show the existence of a study area of samples of medium size (between 90 and 300-390 cases) where the boundaries between both becomes blurred and therefore it is pertinent to discuss the possibility of using samples with methods mixed The field of study of the elites is presented as a fertile area for the development of mixed methods and in particular in the sampling procedure.Finally, some contributions from the experience and practice of research in the field of political and economic elites are described to solve and look for alternatives to improve samples in medium-sized populations, namely: a) the specification of objective criteria in the empirical construction of the object of study, b) the application of expert judgment for the validation of the sample, c) the use of expert peers as a research instrument.
As interpretações teológicas da Declaração Universal dos Direitos Humanos nas Mensagens comemorativas dos Pontificados Pós-conciliares (1968 a 2018)
Authors: Villas Boas Alex , Villas Boas Aline Vicentim 
Published: May 2019

O presente artigo tem o objetivo de analisar as ênfases hermenêuticas e teológicas que os papados pós-conciliares, de 1968 a 2018, deram em suas Mensagens comemorativas da Declaração Universal dos Direitos Humanos, respectivamente às datas dos 20º, 25º, 30º, 40º, 50º, 60º e 70º aniversários. Para isso, irá se analisar como a gramática dos Direitos Humanos é incorporada no Magistério Católico, com João XXIII, e consolidada no Concílio Vaticano II que gera duas grandes ênfases hermenêuticas da dignidade humana, da liberdade humana e das condições de vida digna por meio da justiça social. Os papados pós-conciliares irão desenvolver tais dimensões de acordo com suas respectivas perspectivas e contextos.
Recycling N-acetylcysteine: A review of evidence for adjunctive therapy in schizophrenia
Authors: Willborn Robert J. , Hall Colleen P. , Fuller Matthew A. 
Published: May 2019

AbstractIntroductionAll symptoms in schizophrenia may impact functioning. Although Food and Drug Administration-approved medications typically benefit positive symptoms, negative symptoms are generally refractory to medication interventions. N-acetylcysteine's (NAC) influence on glutamatergic neurotransmission has been established. An emerging body of research has attempted to correlate this action with reduction in symptom severity, evaluating response in positive, negative, and cognitive symptom domains.MethodsA literature review was performed to analyze available data on NAC intervention and improvement in the positive, negative, and cognitive symptom domains in patients with schizophrenia. Quality of evidence was systematically assessed to determine level of certainty in results.ResultsThree randomized controlled trials were identified. Across studies, negative symptoms decreased more with NAC compared to placebo; ranging between 11.9% and 24.1%. The assessment determined a low level of certainty regarding benefit of NAC on negative and cognitive symptoms and moderate certainty for NAC regarding findings of side effects and lack of benefit on positive symptoms.DiscussionConsistent reporting of benefit in negative symptoms is found across studies of NAC intervention. These improvements are notable for symptoms that have generally remained refractory to medication intervention. Inconsistent benefit was reported in positive and cognitive symptoms. GRADE (grading of recommendations assessment, development and evaluation) assessment of current evidence indicates a low certainty of benefit for negative symptoms with standard use of NAC in patients with schizophrenia. However, a trial of this low-risk intervention may be warranted in patients with resistant negative symptoms and subsequent impaired functioning despite appropriate antipsychotic therapy as they may experience additional benefit in this symptom domain.
Clozapine-associated renal failure: A case report and literature review
Authors: Davis Erica A. K. , Kelly Deanna L. 
Published: May 2019

Abstract
One of clozapine's unrecognized potential side effects is renal insufficiency and nephritis. Although most clinicians are aware of the possibility of clozapine-induced myocarditis, less is known about other inflammatory disorders due to clozapine treatment. This patient was started on lithium and clozapine within 4 days of each other although lithium was discontinued after 7 days due to tremor. Routine labs showed an increase in serum creatinine, which was initially attributed to the recent lithium. However, the patient's kidney function continued to worsen, requiring discontinuation of clozapine despite a robust response to a low dose. Several years later, the patient's kidney function improved but has not returned to baseline. This literature review and case report illustrates the similarities in diagnostic presentation of clozapine-associated renal insufficiency as well as potential risk factors. More research should be conducted into the role concomitant sodium valproate and/or lithium play in the risk of clozapine-associated renal insufficiency.
Fairview Pharmacy Services clozapine monitoring program: Description and evaluation of a clinical pharmacy service
Authors: Heins Katharine 
Published: May 2019

Abstract
Fairview Pharmacy Services, part of an academic health system, comprises 35+ outpatient pharmacies in Minneapolis, Minnesota. In 2013, the nonprofit organization opened a satellite location at the University of Minnesota Psychiatry Clinic. The original goals of the service were to improve patient satisfaction and medication adherence through comprehensive pharmaceutical care and clinic provider support. A clozapine monitoring program was envisioned and developed by the pharmacists and now provides optimal medication monitoring, dispensing, and coordination for approximately 100 patients.
α‐synuclein RT‐QuIC in cerebrospinal fluid of LRRK2‐linked Parkinson's disease
Authors: Garrido Alicia , Fairfoul Graham , Tolosa Eduardo S. , Martí Maria José , Green Alison ,   the Barcelona LRRK2 Study Group
Published: May 2019

AbstractBackgroundLeucine‐rich kinase 2 (LRRK2)‐linked Parkinson's disease (PD) is clinically indistinguishable from idiopathic PD (IPD). A pleiotropic neuropathology has been recognized but the majority of studies in LRRK2 p.G2019S patients reveal Lewy‐type synucleinopathy as its principal histological substrate. To date no in vivo biomarkers of synucleinopathy have been found in LRRK2 mutation carriers.ObjectivesWe used real‐time quaking‐induced conversion (RT‐QuIC) technique to assess the presence of alpha‐synuclein (a‐syn) aggregates in cerebrospinal fluid (CSF) of LRRK2 p.G2019S carriers.MethodsCSF samples of 51 subjects were analyzed: 15 LRRK2 p.G2019S PD, 10 IPD, 16 LRRK2 p.G2019S nonmanifesting carriers (NMC) and 10 healthy controls. The presence of parkinsonism and prodromal symptoms was assessed in all study subjects.ResultsForty percent (n = 6) LRRK2‐PD, and 18.8% (n = 3) LRRK2‐NMC had a positive a‐syn RT‐QuIC response. RT‐QuIC detected IPD with 90% sensitivity and 80% specificity. No clinical differences were detected between LRRK2‐PD patients with positive and negative RT‐QuIC. A positive RT‐QuIC result in LRRK2‐NMC occurred in a higher proportion of subjects meeting the Movement Disorder Society research criteria for prodromal PD.InterpretationRT‐QuIC detects a‐syn aggregation in CSF in a significant number of patients with LRRK2‐PD, but less frequently than in IPD. A small percentage of LRRK2‐NMC tested also positive. If appropriately validated in long‐term studies with large number of mutation carriers, and hopefully, postmortem or in vivo confirmation of histopathology, RT‐QuIC could contribute to the selection of candidates to receive disease modifying drugs, in particular treatments targeting a‐syn deposition.
Ice‐Assisted Synthesis of Black Phosphorus Nanosheets as a Metal‐Free Photocatalyst: 2D/2D Heterostructure for Broadband H2 Evolution
Authors: Zhang Qingzhe , Huang Shengyun , Deng Jiujun , Gangadharan Deepak Thrithamarassery , Yang Fan , Xu Zhenhe , Giorgi Giacomo , Palummo Maurizia , Chaker Mohamed , Ma Dongling 
Published: May 2019

AbstractA 2D/2D heterojunction of black phosphorous (BP)/graphitic carbon nitride (g‐C3N4) is designed and synthesized for photocatalytic H2 evolution. The ice‐assisted exfoliation method developed herein for preparing BP nanosheets from bulk BP, leads to high yield of few‐layer BP nanosheets (≈6 layers on average) with large lateral size at reduced duration and power for liquid exfoliation. The combination of BP with g‐C3N4 protects BP from oxidation and contributes to enhanced activity both under λ > 420 nm and λ > 475 nm light irradiation and to long‐term stability. The H2 production rate of BP/g‐C3N4 (384.17 µmol g−1 h−1) is comparable to, and even surpasses that of the previously reported, precious metal‐loaded photocatalyst under λ > 420 nm light. The efficient charge transfer between BP and g‐C3N4 (likely due to formed NP bonds) and broadened photon absorption (supported both experimentally and theoretically) contribute to the excellent photocatalytic performance. The possible mechanisms of H2 evolution under various forms of light irradiation is unveiled. This work presents a novel, facile method to prepare 2D nanomaterials and provides a successful paradigm for the design of metal‐free photocatalysts with improved charge‐carrier dynamics for renewable energy conversion.