bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and characterization of 49 novel microsatellite markers in the African catfish, Clarias gariepinus (Burchell, 1822)
Authors: Kánainé Sipos Dóra , Bakos Katalin , Ősz Ágnes , Hegyi Árpád , Müller Tamás , Urbányi Béla , Kovács Balázs 
Published: September 2019

Abstract
The African catfish or sharp tooth catfish (Clarias gariepinus) is one of the important species (due to its high environmental tolerance and easily controllable breeding habits) that can significantly contribute to reducing hunger in many countries. It is farmed in numerous African, Asian, and European countries. Moreover, during the last decades its production has grown significantly worldwide. Currently, following the carp, this species is produced in the second largest volume in Hungary. Despite its economic importance, the stocks have been maintained without genetic control or guided breeding. Molecular genetic data on bred populations or strains are very limited. In order to investigate the genetic structure of the stocks, 49 new microsatellite markers were characterized and tested on 32 individuals from a Hungarian farmed stock. All these markers were polymorph. The number of alleles per locus ranged from 2 to 11. The observed and expected overall heterozygosities were between 0.519 and 0.544 respectively and the overall inbreeding coefficient (Fis: 0.063) does not reveal the presence of inbreeding. However, 63% of the markers showed significant deviations from HWE. The results suggest that the maintenance of genetic variation within the stock require high attention in closed bred populations. These new markers provide a useful tool for population and conservation genetics of natural and bred African catfish populations.
The Mitochondrial Targets of Neuroprotective Drug Vinpocetine on Primary Neuron Cultures, Brain Capillary Endothelial Cells, Synaptosomes, and Brain Mitochondria
Authors: Svab Gergely , Doczi Judit , Gerencser Akos A. , Ambrus Attila , Gallyas Ferenc , Sümegi Balazs , Tretter László 
Published: September 2019

Abstract
Vinpocetine is considered as neuroprotectant drug and used for treatment of brain ischemia and cognitive deficiencies for decades. A number of enzymes, channels and receptors can bind vinpocetine, however the mechanisms of many effects’ are still not clear. The present study investigated the effects of vinpocetine from the mitochondrial bioenergetic aspects. In primary brain capillary endothelial cells the purinergic receptor-stimulated mitochondrial Ca2+ uptake and efflux were studied. Vinpocetine exerted a partial inhibition on the mitochondrial calcium efflux. In rodent brain synaptosomes vinpocetine (30 μM) inhibited respiration in uncoupler stimulated synaptosomes and decreased H2O2 release from the nerve terminals in resting and in complex I inhibited conditions, respectively. In isolated rat brain mitochondria using either complex I or complex II substrates leak respiration was stimulated, but ADP-induced respiration was inhibited by vinpocetine. The stimulation of oxidation was associated with a small extent of membrane depolarization. Mitochondrial H2O2 production was inhibited by vinpocetine under all conditions investigated. The most pronounced effects were detected with the complex II substrate succinate. Vinpocetine also mitigated both Ca2+-induced mitochondrial Ca2+-release and Ca2+-induced mitochondrial swelling. It lowered the rate of mitochondrial ATP synthesis, while increasing ATPase activity. These results indicate more than a single mitochondrial target of this vinca alkaloid. The relevance of the affected mitochondrial mechanisms in the anti ischemic effect of vinpocetine is discussed.
Normativität unter der Haut
Authors: Antony Alexander 
Published: September 2019

ZusammenfassungDer Aufsatz verfolgt das Ziel, einen theoretischen und empirischen Beitrag zur Soziologie der Kompetenz zu leisten. In Auseinandersetzung mit praxistheoretischen Ansätzen wird argumentiert, dass sich Prozesse der Kompetenzproduktion nicht in einem Demonstrieren körperlicher Fertigkeiten erschöpfen. Sie beruhen vielmehr auch darauf, dass das Tun im Hinblick auf seine normative Angemessenheit beurteilt wird. Das Potenzial einer solchen Perspektivierung wird zunächst anhand körper- und sportsoziologischer Studien vorgeführt. Diese fokussieren allerdings zumeist auf Tätigkeiten, in denen die Kompetenzproduktion primär bei den kommunikativen Dimensionen sozialer Praktiken ansetzt: Kompetenz wirdgezeigt. Die Atemarbeit, eine körperorientierte Therapie- und Selbsterfahrungspraktik, stellt vor diesem Hintergrund einen theoretisch instruktiven Kontrastfall dar. Sie zeichnet sich durch Bewegungsarmut und eine Kultivierung leiblicher Selbstbezüglichkeit aus. Es gerät eine alternative Form der Kompetenzproduktion in den Blick, die gleichsam an den Rändern des Kommunikativen operiert: Kompetenz wirderspürt.
Penile Prosthesis Implantation in an Exstrophy-Epispadias Complex Patient: A Case Report
Authors: Sotimehin Ayodeji E. , Burnett Arthur L. 
Published: September 2019

Abstract
Penile prosthesis implantation (PPI) is a definitive treatment option for patients with medically refractory erectile dysfunction (ED). It is a safe, reliable operation with high patient satisfaction and few complications. We report a novel case of an adult patient with exstrophy-epispadias complex who underwent PPI for ED and discuss the surgical challenges presented by the unique anatomic constraints of this condition.
Agency, Akrasia, and the Normative Environment
Authors: ANTILL GREGORY 
Published: September 2019

AbstractJust as the existence of practical akrasia has been treated as important evidence for the existence of our practical agency, the alleged absence of epistemic akrasia—cases in which a believer believes some proposition contrary to her considered judgments about what she has most reason to believe—has recently been marshaled as grounds for skepticism about the existence of similar forms of epistemic agency. In this paper, I defend the existence of epistemic agency against such objections. Rather than argue against the impossibility of epistemic akrasia, I argue that the impossibility of epistemic akrasia is actuallycompatible withthe existence of epistemic agency. The crucial mistake, I argue, is that skeptics about epistemic agency are failing to distinguish carefully between differences in the structure of believing and acting and differences in the structure of normative reasons to believe and normative reasons to act. I show that once these ‘environmental’ differences are properly distinguished, we can see that absence of epistemic akrasia provides no reason to doubt that practical and epistemic agency are on a par with one another.
Tenure trumps title: Assessing the logic of informant selection in inter-organizational network research
Authors: Beacom Amanda M. , Valente Thomas W. 
Published: September 2019

AbstractResearchers collecting survey data on inter-organizational networks typically choose a single informant with the most senior job title in each organization from whom to obtain a report of the organization’s inter-organizational ties. This approach to informant selection is based on the logic that greater seniority confers greater knowledge of inter-organizational relationships. The present study investigated the wisdom of this logic, using data in which multiple informants’ reports of inter-organizational network ties were collected for each organization. We calculated the degree of agreement in network reports between the informant with the most senior job title and a second informant in the organization. To determine if alternative criteria to seniority serve as better approaches to informant selection, we assessed other potential predictors of agreement in informants’ reports. Results indicated that (1) informants’ perceptions of the network differed significantly according to job title, suggesting little agreement between senior informants and their more junior colleagues; and (2) greater informant tenure in the network and industry were associated with greater agreement among informants. These results call a common data collection practice into question and suggest that tenure may trump title as a criterion for informant selection in inter-organizational network research.
Paleoclimatic record from the clay mineralogy of Quaternary sediments of drill core DWJ from Jiudong subbasin (western Hexi Corridor), NW China
Authors: Chen Dianbao , Pan Baotian , Ma Jinfeng , Hu Xiaofei , Geng Haopeng , Pang Hongli 
Published: September 2019

AbstractThe thick sedimentary deposits of the Jiudong subbasin in the western Hexi Corridor of NW China can potentially provide important records of climate change in arid and semiarid areas subject to the interaction of the East Asian summer monsoon (EASM) and the westerlies. Here we present the results of a study of the clay mineralogy of the sediments of drill core DWJ from the Jiudong subbasin. The clay minerals consist mainly of illite, followed by chlorite, kaolinite, and smectite. The clay mineral assemblages are used to define four paleoclimatic stages since ~1.8 Ma: (1) During ~1.8–1.2 Ma, the climate was relatively cold and arid; (2) during ~1.2–0.9 Ma, it was relatively warm and wet, with strongly seasonal precipitation; (3) during ~0.9–0.3 Ma, there was a long-term trend of cooling and drying; and (4) during ~0.3–0.1 Ma, the climate was warmer and wetter than during the previous period, with strongly seasonal precipitation. The paleoclimatic record of the Jiudong subbasin since ~1.8 Ma is consistent with records from the Tengger Desert and typical monsoonal areas. This suggests that the EASM penetrated into the central regions of the North Qilian Shan and Zhangye–Jiudong subbasin during ~1.2–0.9 and ~0.3–0.1 Ma.
AFRICAN IVORIES AND EIGHTEENTH-CENTURY ENGLISH ANTIQUARIANS
Authors: Hart William 
Published: September 2019

In the late fifteenth and early sixteenth centuries, artists in West Africa made sophisticated ivory carvings specifically for the early Portuguese navigators and their patrons. In researching the history of the ivories, the records of eighteenth-century English antiquarians are a neglected yet important source of information. Such sources help to bridge the gap between the earliest references to Afro-Portuguese ivories in Portuguese customs records (as well as the inventories of royal and princely treasuries of the late Renaissance) and their re-appearance in nineteenth-century museum registers and the collections of private individuals.Especially valuable in this regard are the eighteenth-century minutes of the Society of Antiquaries of London, which enable us to trace the history of several African ivories associated with Fellows of the Society – in particular, Richard Rawlinson, Martin Folkes, Sir Hans Sloane, George Vertue and George Allan. In this article, the author reassesses two African ivories, an oliphant and a saltcellar, with specific reference to the Minutes of the Society of Antiquaries of London, shedding new light on the history of these beautiful objects.
Explaining why childhood abuse is a risk factor for poorer clinical course in bipolar disorder: a path analysis of 923 people with bipolar I disorder
Authors: Marwaha Steven , Briley Paul M. , Perry Amy , Rankin Phillip , DiFlorio Arianna , Craddock Nick , Jones Ian , Broome Matthew , Gordon-Smith Katherine , Jones Lisa 
Published: September 2019

AbstractBackgroundChildhood abuse is a risk factor for poorer illness course in bipolar disorder, but the reasons why are unclear. Trait-like features such as affective instability and impulsivity could be part of the explanation. We aimed to examine whether childhood abuse was associated with clinical features of bipolar disorder, and whether associations were mediated by affective instability or impulsivity.MethodsWe analysed data from 923 people with bipolar I disorder recruited by the Bipolar Disorder Research Network. Adjusted associations between childhood abuse, affective instability and impulsivity and eight clinical variables were analysed. A path analysis examined the direct and indirect links between childhood abuse and clinical features with affective instability and impulsivity as mediators.ResultsAffective instability significantly mediated the association between childhood abuse and earlier age of onset [effect estimate (θ)/standard error (SE): 2.49], number of depressive (θ/SE: 2.08) and manic episodes/illness year (θ/SE: 1.32), anxiety disorders (θ/SE: 1.98) and rapid cycling (θ/SE: 2.25). Impulsivity significantly mediated the association between childhood abuse and manic episodes/illness year (θ/SE: 1.79), anxiety disorders (θ/SE: 1.59), rapid cycling (θ/SE: 1.809), suicidal behaviour (θ/SE: 2.12) and substance misuse (θ/SE: 3.09). Measures of path analysis fit indicated an excellent fit to the data.ConclusionsAffective instability and impulsivity are likely part of the mechanism of why childhood abuse increases risk of poorer clinical course in bipolar disorder, with each showing some selectivity in pathways. They are potential novel targets for intervention to improve outcome in bipolar disorder.
Pure iso-type systems
Authors: YANG YANPENG , OLIVEIRA BRUNO C. D. S. 
Published: September 2019

Abstract
Traditional designs for functional languages (such as Haskell or ML) have separate sorts of syntax for terms and types. In contrast, many dependently typed languages use a unified syntax that accounts for both terms and types. Unified syntax has some interesting advantages over separate syntax, including less duplication of concepts, and added expressiveness. However, integrating unrestricted general recursion in calculi with unified syntax is challenging when some level of type-level computation is present, since properties such as decidable type-checking are easily lost. This paper presents a family of calculi called pure iso-type systems (PITSs), which employs unified syntax, supports general recursion and preserves decidable type-checking. PITS is comparable in simplicity to pure type systems (PTSs), and is useful to serve as a foundation for functional languages that stand in-between traditional ML-like languages and fully blown dependently typed languages. In PITS, recursion and recursive types are completely unrestricted and type equality is simply based on alpha-equality, just like traditional ML-style languages. However, like most dependently typed languages, PITS uses unified syntax, naturally supporting many advanced type system features. Instead of implicit type conversion, PITS provides a generalization of iso-recursive types called iso-types. Iso-types replace the conversion rule typically used in dependently typed calculus and make every type-level computation explicit via cast operators. Iso-types avoid the complexity of explicit equality proofs employed in other approaches with casts. We study three variants of PITS that differ on the reduction strategy employed by the cast operators: call-by-name, call-by-value and parallel reduction. One key finding is that while using call-by-value or call-by-name reduction in casts loses some expressive power, it allows those variants of PITS to have simple and direct operational semantics and proofs. In contrast, the variant of PITS with parallel reduction retains the expressive power of PTS conversion, at the cost of a more complex metatheory.
Are we Ready for a “Microbiome-Guided Behaviour” Approach?
Authors: LAVAZZA ANDREA , SIRONI VITTORIO A. 
Published: September 2019

Abstract:The microbiome is proving to be increasingly important for human brain functioning. A series of recent studies have shown that the microbiome influences the central nervous system in various ways, and consequently acts on the psychological well-being of the individual by mediating, among others, the reactions of stress and anxiety. From a specifically neuroethical point of view, according to some scholars, the particular composition of the microbiome—qua microbial community—can have consequences on the traditional idea of human individuality. Another neuroethical aspect concerns the reception of this new knowledge in relation to clinical applications. In fact, attention to the balance of the microbiome—which includes eating behavior, the use of psychobiotics and, in the treatment of certain diseases, the use of fecal microbiota transplantation—may be limited or even prevented by a biased negative attitude. This attitude derives from a prejudice related to everything that has to do with the organic processing of food and, in general, with the human stomach and intestine: the latter have traditionally been regarded as low, dirty, contaminated and opposed to what belongs to the mind and the brain. This biased attitude can lead one to fail to adequately consider the new anthropological conceptions related to the microbiome, resulting in a state of health, both physical and psychological, inferior to what one might have by paying the right attention to the knowledge available today. Shifting from the ubiquitous high-low metaphor (which is synonymous with superior-inferior) to an inside-outside metaphor can thus be a neuroethical strategy to achieve a new and unbiased reception of the discoveries related to the microbiome.
Patients’ perspectives on imagery rescripting for aversive memories in social anxiety disorder
Authors: Takanashi Rieko , Yoshinaga Naoki , Oshiro Keiko , Matsuki Satoshi , Tanaka Mari , Ibuki Hanae , Oshima Fumiyo , Urao Yuko , Matsuzawa Daisuke , Shimizu Eiji 
Published: September 2019

AbstractBackground:Imagery rescripting (IR) for early aversive memories in patients with social anxiety disorder (SAD) has shown promising results, but no study has investigated the reactions and perspectives of patients who received IR.Aims:This study aimed to gain understanding of patients’ experiences/perspectives on IR as an adjunct to cognitive behavioural therapy (CBT) for SAD.Method:Twenty-five individuals with SAD received one or two sessions of IR over 16 CBT sessions. Contents of recurrent images and linked memories were identified during IR. Outcome measures included social anxiety, image and memory distress and vividness, and encapsulated belief. Patients completed a questionnaire about their perspectives of IR after the session. Thematic analysis was used to analyse the qualitative data.Results:IR resulted in significant within-session improvement in most outcome measures. Linked memories to negative recurrent images in social situations were categorized into nine groups. Common memories were ‘Being criticized by others’, ‘Being made fun of’, ‘Failing or not doing something well’ and ‘Being left out in a group’. Most patients (82%) experienced IR as impressive, and more than half of patients (59%) found IR effective. Themes of reasons of impressiveness and effectiveness were categorized as ‘Results of IR session’ and ‘Processes of IR session’. The theme ‘Results of IR session’ included six subthemes, and the theme ‘Processes of the IR session’ included five subthemes.Conclusions:Regarding patients’ perspectives, although they may experience negative emotions in the process of an IR session, our results suggest that many patients with SAD found IR sessions effective.
E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factors
Authors: Choi Eui-Hwan , Kim Keun Pil 
Published: September 2019

AbstractThe human genome is constantly exposed to both endogenous and exogenous stresses, which can lead to errors in DNA replication and the accumulation of DNA mutations, thereby increasing the risk of cancer development. The transcription factor E2F1 is a key regulator of DNA repair. E2F1 also has defined roles in the replication of many cell cycle-related genes and is highly expressed in cancer cells, and its abundance is strongly associated with poor prognosis in cancers. Studies on colon cancer have demonstrated that the depletion of E2F1 leads to reduced levels of homologous recombination (HR), resulting in interrupted DNA replication and the subsequent accumulation of DNA lesions. Our results demonstrate that the depletion of E2F1 also causes reduced RAD51-mediated DNA repair and diminished cell viability resulting from DNA damage. Furthermore, the extent of RAD51 and RPA colocalization is reduced in response to DNA damage; however, RPA single-stranded DNA (ssDNA) nucleofilament formation is not affected following the depletion of E2F1, implying that ssDNA gaps accumulate when RAD51-mediated DNA gap filling or repair is diminished. Surprisingly, we also demonstrate that E2F1 forms foci with RAD51 or RPA at DNA break sites on damaged DNA. These findings provide evidence of a molecular mechanism underlying the E2F1-mediated regulation of HR activity and predict a fundamental shift in the function of E2F1 from regulating cell division to accelerating tumor development.
Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache
Authors: Bonnet Caroline , Hao Jizhe , Osorio Nancy , Donnet Anne , Penalba Virginie , Ruel Jérôme , Delmas Patrick 
Published: September 2019

AbstractMedication-overuse headaches (MOH) occur with both over-the-counter and pain-relief medicines, including paracetamol, opioids and combination analgesics. The mechanisms that lead to MOH are still uncertain. Here, we show that abnormal activation of Nav1.9 channels by Nitric Oxide (NO) is responsible for MOH induced by triptan migraine medicine. Deletion of theScn11agene in MOH mice abrogates NO-mediated symptoms, including cephalic and extracephalic allodynia, photophobia and phonophobia. NO strongly activates Nav1.9 in dural afferent neurons from MOH but not normal mice. Abnormal activation of Nav1.9 triggers CGRP secretion, causing artery dilatation and degranulation of mast cells. In turn, released mast cell mediators potentiates Nav1.9 in meningeal nociceptors, exacerbating inflammation and pain signal. Analysis of signaling networks indicates that PKA is downregulated in trigeminal neurons from MOH mice, relieving its inhibitory action on NO-Nav1.9 coupling. Thus, anomalous activation of Nav1.9 channels by NO, as a result of chronic medication, promotes MOH.
Global agricultural concept space: lightweight semantics for pragmatic interoperability
Authors: Baker Thomas , Whitehead Brandon , Musker Ruthie , Keizer Johannes 
Published: September 2019

AbstractProgress on research and innovation in food technology depends increasingly on the use of structured vocabularies—concept schemes, thesauri, and ontologies—for discovering and re-using a diversity of data sources. Here, we report on GACS Core, a concept scheme in the larger Global Agricultural Concept Space (GACS), which was formed by mapping between the most frequently used concepts of AGROVOC, CAB Thesaurus, and NAL Thesaurus and serves as a target for mapping near-equivalent concepts from other vocabularies. It provides globally unique identifiers, which can be used as keywords in bibliographic databases, tags for web content, for building lightweight facet schemes, and for annotating spreadsheets, databases, and image metadata using synonyms and variant labels in 25 languages. The minimal semantics of GACS allows terms defined with more precision in ontologies, or less precision in controlled vocabularies, to be linked together making it easier to discover and integrate semantically diverse data sources.