bluuebunny/crossref_metadata_2025_split huggingface dataset:
A software engineering team research mapping study
Authors: DeFranco Joanna F. , Laplante Phillip 
Published: March 2018

Purpose
The purpose of this mapping study has been performed to identify, critically analyze and synthesize research performed in the area of software engineering teams. Teams, in a general sense, have been studied extensively. But the distinctive processes that need to be executed effectively and efficiently in software engineering require a better understanding of current software engineering team research.

Design/methodology/approach
In this work, software engineering team publications were analyzed and the key findings of each paper that met our search inclusion criteria were synthesized. In addition, a keyword content analysis was performed to create a taxonomy to categorize each paper and evaluate the state of software engineering team research.

Findings
In software engineering team research, the resulting areas that are the most active are teamwork/collaboration, process/design and coordination. Clear themes of analysis have been determined to help understand how team members collaborate, factors affecting their success and interactions among all project stakeholders. In addition, themes related to tools to support team collaboration, improve the effectiveness of software engineering processes and support team coordination have been found. However, the research gaps determined from the content analysis point toward a need for more research in the area of communication and tools.

Originality/value
The goal of this work is to define the span of previous research in this area, create a taxonomy to categorize such research and identify open research areas to provide a clear road map for future research in the area of software engineering teams. These results, along with the key finding themes presented, will help guide future research in an area that touches all parts of the software engineering and development processes.
Fimasartan increases glucose‐stimulated insulin secretion in patients with type 2 diabetes and hypertension compared with amlodipine
Authors: Yang Ye Seul , Lim Min Hyuk , Lee Seong Ok , Roh Eun , Ahn Chang Ho , Kwak Soo Heon , Cho Young Min , Kim Sungwan , Mari Andrea , Park Kyong Soo , Jung Hye Seung 
Published: March 2018

AimTo study the effects of angiotensin receptor blockers (ARBs) on insulin secretion in hypertensive patients with type 2 diabetes.Materials and methodsA total of 41 patients were enrolled in this open‐label, active comparator‐controlled, crossover study. After a 2‐week run‐in period with amlodipine, the participants were assigned to receive either fimasartan (60–120 mg daily) or amlodipine (5–10 mg daily) for 16 weeks. Thereafter, they were treated with the other drug for another 16 weeks. Physical examinations and laboratory tests were performed before and after each treatment.ResultsBlood pressure, glycated haemoglobin and oral glucose tolerance test (OGTT) values were similar with each treatment. Fimasartan treatment significantly increased median (range) homeostatic assessment of β‐cell function values (49.9 [22.5–174.4] vs 46.9 [15.6–148.0]), area under the curve of insulin during OGTT (27 284 [9501–94 525] vs 26 818 [8112–76 704] pmol/L × min), insulinogenic index at 60 minutes (19.7 [3.0–131.2] vs 15.0 [2.4–103.8] pmol/mmol) and at 120 minutes (19.1 [1.9–85.5] vs 12.6 [−4.3–178.8] pmol/mmol) compared with those with amlodipine (all P < .05); however, acute insulin response and insulin resistance indices were similar for both agents.ConclusionsCompared with amlodipine, fimasartan increased late‐phase glucose‐stimulated insulin secretion in patients with type 2 diabetes and hypertension. This finding suggests that ARBs would be more beneficial in such patients compared with other classes of anti‐hypertensives.
Nurses’ knowledge and attitudes regarding major immobility complications among bedridden patients: A prospective multicentre study
Authors: Li Zhen , Zhou Xinmei , Cao Jing , Li Zheng , Wan Xia , Li Jiaqian , Jiao Jing , Liu Ge , Liu Ying , Li Fangfang , Song Baoyun , Jin Jingfen , Liu Yilan , Wen Xianxiu , Cheng Shouzhen , Wu Xinjuan 
Published: March 2018

Aims and objectivesTo gain insight into nurses’ knowledge and attitudes regarding major immobility complications (pressure ulcers, pneumonia, deep vein thrombosis and urinary tract infections) and explore the correlation of nurses’ knowledge and attitudes with the incidence of these complications.BackgroundImmobility complications have adverse consequences, and effective management requires appropriate knowledge, attitudes and skills. Evidence about nurses’ knowledge and attitudes regarding immobility complications is lacking.DesignCross‐sectional study.MethodsA total of 3,903 nurses and 21,333 bedridden patients from 25 hospitals in China were surveyed. Nurses’ knowledge and attitudes regarding major immobility complications were assessed using researcher‐developed questionnaires. The content validity, reliability and internal consistency of the questionnaires were validated through expert review and a pilot study. The incidence of major immobility complications among bedridden patients from selected wards was surveyed by trained investigators. Correlations between knowledge, attitudes and the incidence of major immobility complications were evaluated with multilevel regression models.ResultsMean knowledge scores were 64.07% for pressure ulcers, 72.92% for deep vein thrombosis, 76.54% for pneumonia and 83.30% for urinary tract infections. Mean attitude scores for these complications were 86.25%, 84.31%, 85.00% and 84.53%, respectively. Knowledge and attitude scores were significantly higher among nurses with older age, longer employment duration, higher education level, previous training experience and those working in tertiary hospitals or critical care units. Nurses’ knowledge about pressure ulcers was negatively related to the incidence of pressure ulcers, and attitude towards pneumonia was negatively correlated with the incidence of pneumonia.ConclusionClinical nurses have relatively positive attitudes but inadequate knowledge regarding major immobility complications. Improved knowledge and attitudes regarding major immobility complications may contribute to reducing these complications.Relevance to Clinical PracticeNursing managers should implement measures to improve nurses’ knowledge and attitudes regarding major immobility complications to reduce the incidence of these complications in bedridden patients.
TonB-Dependent Receptor Repertoire of Pseudomonas aeruginosa for Uptake of Siderophore-Drug Conjugates
Authors: Luscher Alexandre , Moynié Lucile , Auguste Pamela Saint , Bumann Dirk , Mazza Lena , Pletzer Daniel , Naismith James H. , Köhler Thilo 
Published: March 2018

ABSTRACT

The conjugation of siderophores to antimicrobial molecules is an attractive strategy to overcome the low outer membrane permeability of Gram-negative bacteria. In this Trojan horse approach, the transport of drug conjugates is redirected via TonB-dependent receptors (TBDR), which are involved in the uptake of essential nutrients, including iron. Previous reports have demonstrated the involvement of the TBDRs PiuA and PirA from
Pseudomonas aeruginosa
and their orthologues in
Acinetobacter baumannii
in the uptake of siderophore-beta-lactam drug conjugates. By
in silico
screening, we further identified a PiuA orthologue, termed PiuD, present in clinical isolates, including strain LESB58. The
piuD
gene in LESB58 is located at the same genetic locus as
piuA
in strain PAO1. PiuD has a similar crystal structure as PiuA and is involved in the transport of the siderophore-drug conjugates BAL30072, MC-1, and cefiderocol in strain LESB58. To screen for additional siderophore-drug uptake systems, we overexpressed 28 of the 34 TBDRs of strain PAO1 and identified PfuA, OptE, OptJ, and the pyochelin receptor FptA as novel TBDRs conferring increased susceptibility to siderophore-drug conjugates. The existence of a TBDR repertoire in
P. aeruginosa
able to transport siderophore-drug molecules potentially decreases the likelihood of resistance emergence during therapy.
Assessing Travel Conditions: Environmental and Host Influences on Bacterial Surface Motility
Authors: Mattingly Anne E. , Weaver Abigail A. , Dimkovikj Aleksandar , Shrout Joshua D. 
Published: March 2018

ABSTRACT
The degree to which surface-motile bacteria explore their surroundings is influenced by aspects of their local environment. Accordingly, the regulation of surface motility is controlled by numerous chemical, physical, and biological stimuli. The discernment of such regulation due to these multiple cues is a formidable challenge. Additionally, inherent ambiguity and variability from the assays used to assess surface motility can be obstacles to clear the delineation of regulated surface motility behavior. Numerous studies have reported single environmental determinants of microbial motility and lifestyle behavior, but the translation of these data to understand surface motility and bacterial colonization of human host or environmental surfaces is unclear. Here, we describe the current state of the field and our understanding of exogenous factors that influence bacterial surface motility.
Immunogenicity and Cross-Reactivity of Rhesus Adenoviral Vectors
Authors: Iampietro M. Justin , Larocca Rafael A. , Provine Nicholas M. , Abbink Peter , Kang Zi Han , Bricault Christine A. , Barouch Dan H. 
Published: March 2018

ABSTRACT
Adenovirus (Ad) vectors are being investigated as vaccine candidates, but baseline antivector immunity exists in human populations to both human Ad (HuAd) and chimpanzee Ad (ChAd) vectors. In this study, we investigated the immunogenicity and cross-reactivity of a panel of recently described rhesus adenoviral (RhAd) vectors. RhAd vectors elicited T cells with low exhaustion markers and robust anamnestic potential. Moreover, RhAd vector immunogenicity was unaffected by high levels of preexisting anti-HuAd immunity. Both HuAd/RhAd and RhAd/RhAd prime-boost vaccine regimens were highly immunogenic, despite a degree of cross-reactive neutralizing antibodies (NAbs) between phylogenetically related RhAd vectors. We observed extensive vector-specific cross-reactive CD4 T cell responses and more limited CD8 T cell responses between RhAd and HuAd vectors, but the impact of vector-specific cellular responses was far less than that of vector-specific NAbs. These data suggest the potential utility of RhAd vectors and define novel heterologous prime-boost strategies for vaccine development.

IMPORTANCE
To date, most adenoviral vectors developed for vaccination have been HuAds from species B, C, D, and E, and human populations display moderate to high levels of preexisting immunity. There is a clinical need for new adenoviral vectors that are not hindered by preexisting immunity. Moreover, the development of RhAd vector vaccines expands our ability to vaccinate against multiple pathogens in a population that may have received other HuAd or ChAd vectors. We evaluated the immunogenicity and cross-reactivity of RhAd vectors, which belong to the poorly described adenovirus species G. These vectors induced robust cellular and humoral immune responses and were not hampered by preexisting anti-HuAd vector immunity. Such properties make RhAd vectors attractive as potential vaccine vectors.
What interventions can improve quality of life or psychosocial factors of individuals with knee osteoarthritis? A systematic review with meta-analysis of primary outcomes from randomised controlled trials
Authors: Briani Ronaldo Valdir , Ferreira Amanda Schenatto , Pazzinatto Marcella Ferraz , Pappas Evangelos , De Oliveira Silva Danilo , Azevedo Fábio Mícolis de 
Published: March 2018

ObjectiveTo systematically review evidence of primary outcomes from randomised controlled trials (RCTs) examining the effect of treatment strategies on quality of life (QoL) or psychosocial factors in individuals with knee osteoarthritis (OA).DesignSystematic review with meta-analysis.Data sourcesMedline, Embase, SPORTDiscus, the Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Web of Science were searched from inception to November 2017.Eligibility criteria for selecting studiesWe included RCTs investigating the effect of conservative interventions on QoL or psychosocial factors in individuals with knee OA. Only RCTs considering these outcomes as primary were included.ResultsPooled data supported the use of exercise therapy compared with controls for improving health-related and knee-related QoL. There was limited evidence that a combined treatment of yoga, transcutaneous electrical stimulation and ultrasound may be effective in improving QoL. Limited evidence supported the use of cognitive behavioural therapies (with or without being combined with exercise therapy) for improving psychosocial factors such as self-efficacy, depression and psychological distress.Summary/ConclusionExercise therapy (with or without being combined with other interventions) seems to be effective in improving health-related and knee-related QoL or psychosocial factors of individuals with knee OA. In addition, evidence supports the use of cognitive behavioural therapies (with or without exercise therapy) for improving psychosocial factors such as self-efficacy, depression and psychological distress in individuals with knee OA.PROSPERO registration numberCRD42016047602.
Therapeutic effects of aerobic and resistance exercises for cancer survivors: a systematic review of meta-analyses of clinical trials
Authors: Fuller Joel T , Hartland Michael C , Maloney Luke T , Davison Kade 
Published: March 2018

ObjectiveTo systematically appraise and summarise meta-analyses investigating the effect of exercise compared with a control condition on health outcomes in cancer survivors.DesignUmbrella review of intervention systematic reviews.Data sourcesWeb of Science, Scopus, Cochrane Library, CINAHL and MEDLINE databases were searched using a predefined search strategy.Eligibility criteriaEligible meta-analyses compared health outcomes between cancer survivors participating in an exercise intervention and a control condition. Health outcomes were cardiovascular fitness, muscle strength, health-related quality of life, cancer-related fatigue and depression. Pooled effect estimates from each meta-analysis were quantified using standardised mean differences and considered trivial (<0.20), small (0.20–0.49), moderate (0.50–0.79) and large (≥0.80). Findings were summarised using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system.ResultsThere were 65 eligible articles that reported a total of 140 independent meta-analyses. 139/140 meta-analyses suggested a beneficial effect of exercise. The beneficial effect was statistically significant in 104 (75%) meta-analyses. Most effect sizes were moderate for cardiovascular fitness and muscle strength and small for cancer-related fatigue, health-related quality of life and depression. The quality of evidence was variable according to the GRADE scale, with most studies rated low or moderate quality. Median incidence of exercise-related adverse events was 3.5%.ConclusionExercise likely has an important role in helping to manage physical function, mental health, general well-being and quality of life in people undergoing and recovering from cancer and side effects of treatment.PROSPERO registration numberCRD42015020194.
Reappraisal of previously reported meta-analyses on antibiotic prophylaxis for low-risk laparoscopic cholecystectomy: an overview of systematic reviews
Authors: Matsui Yoichi , Satoi Sohei , Hirooka Satoshi , Kosaka Hisashi , Kawaura Takayuki , Kitawaki Tomoki 
Published: March 2018

IntroductionMany researchers have addressed overdosage and inappropriate use of antibiotics. Many meta-analyses have investigated antibiotic prophylaxis for low-risk laparoscopic cholecystectomy with the aim of reducing unnecessary antibiotic use. Most of these meta-analyses have concluded that prophylactic antibiotics are not required for low-risk laparoscopic cholecystectomies. This study aimed to assess the validity of this conclusion by systematically reviewing these meta-analyses.MethodsA systematic review was undertaken. Searches were limited to meta-analyses and systematic reviews. PubMed and Cochrane Library electronic databases were searched from inception until March 2016 using the following keyword combinations: ‘antibiotic prophylaxis’, ‘laparoscopic cholecystectomy’ and ‘systematic review or meta-analysis’. Two independent reviewers selected meta-analyses or systematic reviews evaluating prophylactic antibiotics for laparoscopic cholecystectomy. All of the randomised controlled trials (RCTs) analysed in these meta-analyses were also reviewed.ResultsSeven meta-analyses regarding prophylactic antibiotics for low-risk laparoscopic cholecystectomy that had examined a total of 28 RCTs were included. Review of these meta-analyses revealed 48 miscounts of the number of outcomes. Six RCTs were inappropriate for the meta-analyses; one targeted patients with acute cholecystitis, another measured inappropriate outcomes, the original source of a third was not found and the study protocols of the remaining three were not appropriate for the meta-analyses. After correcting the above miscounts and excluding the six inappropriate RCTs, pooled risk ratios (RRs) were recalculated. These showed that, contrary to what had previously been concluded, antibiotics significantly reduced the risk of postoperative infections. The rates of surgical site, distant and overall infections were all significantly reduced by antibiotic administration (RR (95% CI); 0.71 (0.51 to 0.99), 0.37 (0.19 to 0.73), 0.50 (0.34 to 0.75), respectively).ConclusionsProphylactic antibiotics reduce the incidence of postoperative infections after elective laparoscopic cholecystectomy.
Assessment of patient-reported outcomes after polytrauma: protocol for a systematic review
Authors: Gnass Irmela , Ritschel Michaela , Andrich Silke , Kuske Silke , Moschinski Kai , Herrmann-Frank Annegret , Metzendorf Maria-Inti , Flohé Sascha , Sturm Johannes , Windolf Joachim , Icks Andrea 
Published: March 2018

IntroductionSurvivors of polytrauma experience long-term and short-term burden that influences their lives. The patients’ view of relevant short-term and long-term outcomes should be captured in instruments that measure quality of life and other patient-reported outcomes (PROs) after a polytrauma. The aim of this systematic review is to (1) collect instruments that assess PROs (quality of life, social participation and activities of daily living) during follow-up after polytrauma, (2) describe the instruments’ application (eg, duration of period of follow-up) and (3) investigate other relevant PROs that are also assessed in the included studies (pain, depression, anxiety and cognitive function).Methods and analysisThe systematic review protocol is developed in line with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols statement. MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature, PsycINFO, Cochrane Central Register of Controlled Trials and the trials registers ClinicalTrials.gov and WHO International Clinical Trials Registry Platform will be searched. Keywords, for example, ‘polytrauma’, ‘multiple trauma’, ‘quality of life’, ‘activities of daily living’ or ‘pain’ will be used. Publications published between January 2005 and the most recent date (currently: August 2016) will be included. In order to present the latest possible results, an update of the search is conducted before publication. The data extraction and a content analysis will be carried out systematically. A critical appraisal will be performed.Ethics and disseminationFormal ethical approval is not required as primary data will not be collected. The results will be published in a peer-reviewed publication.PROSPERO registration numberCRD42017060825.
Role of viral and bacterial pathogens in causing pneumonia among Western Australian children: a case–control study protocol
Authors: Bhuiyan Mejbah Uddin , Snelling Thomas L , West Rachel , Lang Jurissa , Rahman Tasmina , Borland Meredith L , Thornton Ruth , Kirkham Lea-Ann , Sikazwe Chisha , Martin Andrew C , Richmond Peter C , Smith David W , Jaffe Adam , Blyth Christopher C 
Published: March 2018

IntroductionPneumonia is the leading cause of childhood morbidity and mortality globally. Introduction of the conjugateHaemophilus influenzaeB and multivalent pneumococcal vaccines in developed countries including Australia has significantly reduced the overall burden of bacterial pneumonia. With the availability of molecular diagnostics, viruses are frequently detected in children with pneumonia either as primary pathogens or predispose to secondary bacterial infection. Many respiratory pathogens that are known to cause pneumonia are also identified in asymptomatic children, so the true contribution of these pathogens to childhood community-acquired pneumonia (CAP) remains unclear. Since the introduction of pneumococcal vaccines, very few comprehensive studies from developed countries have attempted to determine the bacterial and viral aetiology of pneumonia. We aim to determine the contribution of bacteria and viruses to childhood CAP to inform further development of effective diagnosis, treatment and preventive strategies.Methods and analysisWe are conducting a prospective case–control study (PneumoWA) where cases are children with radiologically confirmed pneumonia admitted to Princess Margaret Hospital for Children (PMH) and controls are healthy children identified from PMH outpatient clinics and from local community immunisation clinics. The case–control ratio is 1:1 with 250 children to be recruited in each arm. Nasopharyngeal swabs are collected from both cases and controls to detect the presence of viruses and bacteria by PCR; pathogen load will be assessed by quantitative PCR. The prevalence of pathogens detected in cases and controls will be compared, the OR of detection and population attributable fraction to CAP for each pathogen will be determined; relationships between pathogen load and disease status and severity will be explored.Ethics and disseminationThis study has been approved by the human research ethics committees of PMH, Perth, Australia (PMH HREC REF 2014117EP). Findings will be disseminated at research conferences and in peer-reviewed journals.