bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic Effects of Freeze‐Thaw Pretreatment and Ultrasound on the Structure and Digestibility of Starch–Lipid Complexes
Authors: Li Junhui , Li Jinjun , Deng Yuanhao , Fang Yizhou , Li Shan , Chen Shiguo 
Published: November 2024

AbstractStarch inclusion complexes are gaining interest due to their enhanced functional properties and potential health benefits. Both freeze‐thawing and ultrasound are recognized as effective physical methods to induce the formation of V‐type starch inclusion complexes. However, the combined effects of these treatments on starch complex formation have not been fully elucidated. This study aims to investigate the synergistic impact of ultrasound and freeze‐thaw treatments on the production of corn starch–glycerin monostearin complexes (GMS), examining their structural and digestive properties. The findings, supported by X‐ray diffraction (XRD) and complexing index analyses, indicate a synergistic effect from the combined treatment in creating V‐type starch–lipid inclusion complexes. Scanning electron microscopy (SEM) shows that the application of freeze‐thaw cycles and ultrasound leads to the release of amylose molecules, enhancing their interaction with lipid molecules. The starch–lipid complexes formed through this process exhibit a highly ordered structure and increased resistance to enzymatic digestion in an in vitro model. These results offer valuable insights into the development of starch‐based foods with slower digestibility, which could have implications for dietary management and the functional food industry.
Relationship between physical activity and biomarkers of pathology and neuroinflammation in preclinical autosomal‐dominant Alzheimer's disease
Authors: Guzmán‐Vélez Edmarie , Rivera‐Hernández Angelys , Fabrega Sofia , Oliveira Gabriel , Martínez Jairo E. , Baena Ana , Picard Glen , Lopera Francisco , Arnold Steven E. , Taylor J Andrew , Quiroz Yakeel T. 
Published: November 2024

AbstractObjectivePhysical activity (PA) has been linked to reduced Alzheimer's disease (AD) risk. However, less is known about its effects in the AD preclinical stage. We aimed to investigate whether greater PA was associated with lower plasma biomarkers of AD pathology, neural injury, reactive astrocytes, and better cognition in individuals with autosomal‐dominant AD due to the presenilin‐1 E280A mutation who are virtually guaranteed to develop dementia.MethodsTwenty‐eight cognitively unimpaired mutation carriers (ages x̄ = 29.28) wore a FitBit Charge‐4 for 14 days. We calculated their average steps to measure locomotion, and Training Impulse (TRIMP) to quantify the intensity and duration of PAs using heart rate. Plasma amyloid beta 42/40 ratio, phosphorylated tau 181, neurofilament light chain, and glial fibrillary acidic protein (GFAP) were measured. Cognition was assessed with the Consortium to Establish a Registry for Alzheimer's Disease word list learning and delayed recall, Trail Making Test Part A, and Wechsler Adult Intelligence Scale‐version IV Digit Span Backward. We conducted multiple linear regressions controlling for age, sex, body mass index, and education.ResultsThere were no associations among steps or TRIMP with plasma biomarkers or cognition. Greater TRIMP was related to higher GFAP levels.ConclusionsPA was not associated with cognition or plasma biomarkers. However, greater intensity and duration of PAs were related to higher GFAP. Participants engaged very little in moderate to vigorous PA. Therefore, light PA may not exert a significant protective effect in preclinical AD. Future work with larger samples and longitudinal data is needed to elucidate further the potential impact of PA on AD progression in the preclinical stages.Highlights
Locomotion (average steps) was not associated with plasma biomarkers or cognition.
Greater training load (training impulse) was related to higher glial fibrillary acidic protein levels in mutation carriers.
Light physical activity may not suffice to exert a protective effect on Alzheimer's disease.
Poisoning by polytetrafluoroethylene (Teflon) in two albino cockatiels (Nymphicus hollandicus)
Authors: Rezende Pedro Almeida , de Lima Jordana Pinto , dos Santos Carneiro Lacerda Maira , Lopes Carlos Eduardo Bastos , Lopes Marcelo Coelho , Amaral Camila Issa , Ecco Roselene 
Published: November 2024

AbstractTwo 35‐day‐old, female albino cockatiels (Nymphicus hollandicus), were received for postmortem examination after an acute onset of changes in the vocalisation followed by sudden death. Behavioural changes and mortality were not observed in any of the contacting adult birds. The owner reported a domestic accident associated with the overheating of a non‐stick cookware and the consequent release and accumulation of smoke in the environment, which coincided with the sudden mortality of the young birds. The most consistent gross and histopathological findings were diffuse pulmonary congestion, oedema and haemorrhage. The association of the history with the anatomopathological findings allowed a presumptive diagnosis of acute respiratory failure associated with polytetrafluoroethylene poisoning in two housed birds. This case reinforces the need to take care of the environmental conditions in which these birds are exposed.
Introduction: Imagining “Europe” in Times of War and Crises: Youth Perceptions of European Integration in its Periphery
Authors: Alpan Başak , Hoti Afrim 
Published: November 2024

AbstractThis chapter sets the conceptual and theoretical scene for the broader focus of this volume, which aims to explore the perceptions attached to the EU integration by the young population in its “periphery”. In line with the research questions of the LEAP (“Linking to Europe at the Periphery”) Jean Monnet Network, which aims to explore how the EU integration is taught, learned, experienced and contested at the periphery of the EU, the chapter aims to kick-off the discussion on the perceptions of the EU integration in the periphery mainly against the background of numerous crises characterising the European project lately. After endeavouring to conceptually spot the “periphery” of the EU integration, we delve into the perception studies, focusing on the perceptions of the EU integration by the young population in the “periphery”. The chapter also elaborates on the research methodology of the volume, as well as introducing the structure of the chapters of the book.
Role and Safety of Tirofiban in Peri-Interventional Antiplatelet Management for Aneurysm Treatment
Authors: Garayzade Rana , Berlis Ansgar , Arndt Tim Tobias , Wolfert Christina , Sommer Björn , Müller Gernot , Maurer Christoph J. 
Published: November 2024

Abstract
Background
Tirofiban is administered for the treatment of aneurysms in cases of thromboembolic complications, as well as in cases of acute stenting or flow-diverter implantation required within the scope of aneurysm treatment. We aimed to investigate the efficacy and safety of tirofiban in this group of patients.

Methods
We conducted a retrospective analysis of all patients undergoing aneurysm treatment and receiving peri-interventional tirofiban administration at our institution between 2009 and 2019.

Results
A total of 105 patients were included, with 61% women and 39% men (mean age = 53 years, IQR: 44–60 years). Sixty-seven patients underwent emergency aneurysm treatment, and thirty-eight were treated electively. Hemorrhagic events occurred in 22% (15/67) of the patients treated acutely, with 7.46% (5/67) exhibiting symptoms. Patients undergoing elective aneurysm treatment experienced no hemorrhagic events (p = 0.002). Among the 35 patients who required an external ventricular drain (EVD), 22.86% (8/35) developed EVD-related hemorrhages; however, none were symptomatic (p = 0.007). Of the five patients who required a craniotomy, two experienced significant bleeding, and one experienced non-significant craniotomy-related bleeding (p = 0.20).

Conclusion
Tirofiban may be safe for use during peri-interventional complications or emergency stenting in aneurysm treatment. However, caution is necessary when craniotomy is required. In elective aneurysm treatments, administering Tirofiban in response to periprocedural complications appears to be safe.
Bacterial Resilience and Community Shifts Under 11 Draining-Flooding Cycles in Rice Soils
Authors: de Freitas Anderson Santos , Carlos Filipe Selau , Martins Guilherme Lucio , Monteiro Gabriel Gustavo Tavares Nunes , Roesch Luiz Fernando Wurdig 
Published: November 2024

AbstractFlooded rice cultivation, accounting for 75% of global rice production, significantly influences soil redox potential, element speciation, pH, and nutrient availability, presenting challenges such as extensive water usage and altered soil properties. This study investigates bacterial community dynamics in rice soils subjected to repeated draining and flooding in Rio Grande do Sul, Brazil. We demonstrate that bacterial communities exhibit remarkable resilience (the capacity to recover after being altered by a disturbance) but cannot remain stable after long-term exposure to environmental changes. The beta diversity analysis revealed four distinct community states after 11 draining/flooding cycles, indicating resilience over successive environment changes. However, the consistent environmental disturbance reduced microbial resilience, causing the bacterial community structure to shift over time. Those differences were driven by substitutions of taxa and functions and not by the loss of diversity. Notable shifts included a decline in Acidobacteria and an increase in Proteobacteria and Chloroflexi. Increased Verrucomicrobia abundance corresponded with lower pH levels. Functional predictions suggested dynamic metabolic responses, with increased nitrification during drained cycles and a surge in fermenters after the sixth cycle. Despite cyclic disturbances, bacterial communities exhibit resilience, contributing to stable ecosystem functioning in flooded rice soils. These findings enhance our understanding of microbial adaptation, providing insights into sustainable rice cultivation and soil management practices.
An unexpected variation of occipital and ascending pharyngeal arteries: clinical implications
Authors: Roofeh Gabriella , Matthees Nicholas , Cevallos Manuel 
Published: November 2024

Abstract
Purpose
The eight typical External Carotid Artery (ECA) branches are the superior thyroid artery, ascending pharyngeal artery, lingual artery, facial artery, occipital artery, posterior auricular artery, maxillary artery, and superficial temporal artery. The Internal Carotid Artery (ICA) has no branches in the cervical region before entering the carotid canal. We identified a variant of the Occipital Artery (OA) and Ascending Pharyngeal Artery (APA) originating in the cervical portion of the ICA and wish to explore the clinical implications this variation may have.

Methods
Between August and December 2023, 28 formaldehyde donors were dissected in the anatomy course for first-year medical and physician assistant students at the Creighton University School of Medicine, Phoenix campus.

Results
In one donor, dissection of the right common carotid artery (CCA) revealed a variation of the ECA branches. Two branches were found on the proximal portion of the ICA. After tracing the branches cranially, we identified these as the OA and APA. These two arteries typically originate from the ECA. The bifurcation angle was observed to be nearly 180 degrees. This variation was only observed on the right side.

Conclusion
As the prevalence of this variation has only been described in one study, reporting at 0.14%, documentation and education of this anatomy aids surgeons and interventional radiologists in head and neck procedures. Exploring the paths of these ectopic arteries promotes informed decision making and risk stratification for carotid endarterectomy, arterial embolization, bypass procedures, and arterial harvesting. Furthermore, performing thorough imaging such as CT angiograms on patients preoperatively provides better foresight to minimize complications.
Functional Diversity of A-Type RING Ligases (ATL) Genes: Insights into the Crucial Roles of E3 Ubiquitin Ligases in Plant Biology
Authors: Sierra-Cacho Daniel , Méndez-Gómez Manuel , Aguilar-Hernández Victor , Guzmán Plinio 
Published: November 2024

AbstractE3 ubiquitin ligases are vital components of the ubiquitin–proteasome system (UPS), responsible for maintaining protein balance and controlling cellular functions. E3 ligases target specific proteins for degradation or modify their activities through ubiquitin attachment. One prominent E3 ligase family is the ATL family, which comprises 100 members in Arabidopsis thaliana and has significantly expanded in plant genomes. All ATLs share a common domain architecture, featuring a transmembrane domain at the amino-terminal region, a distinct RING-H2 finger domain, and the GLD motif. The RING domain facilitates interactions between E3 ligases, E2-conjugating enzymes, and target proteins, enabling the transfer of ubiquitin molecules. The amino-terminal and carboxy-terminal regions introduce sequence diversity and potentially mediate interactions with other components that assist in UPS function or target recognition. ATLs had been classified within groups, each group encompasses specific ATLs with defined roles in various biological processes. For example, group C-ATLs are implicated in drought tolerance, flower development, phosphate homeostasis, and immune signaling. G-ATLs are associated with carbon/nitrogen stress, immune signaling, salt stress, ABA responses, cadmium tolerance, and sugar-mediated plant growth. A-ATLs participate in early elicitor-response, salt and drought responses, and flowering time regulation. Lastly, D-ATLs are involved in the regulation of programmed cell death. This review let perceive ATLs as a cohesive group of E3 ligases, shedding light on their functional diversifity and redundancy, specifically examining their participation in diverse biological processes, explore their evolutionary history shaped by gene duplication events, and appraise their interactions with key proteins and targets of ubiquitination. This comprehensive overview aims to offer insights into the role of ATLs in plant adaptation, defense mechanisms, and stress tolerance, while also underlying molecular and evolutionary mechanisms and regulatory networks that govern these processes.
Greater resting state functional connectivity of the medial prefrontal cortex with the thalamus, caudate, and putamen in individuals who adhere to the Mediterranean style diets
Authors: Faulkner Paul , Allen Paul , Costabile Adele , Schoemaker Marieke H. , Imakulata Florencia , Hepsomali Piril 
Published: November 2024

Abstract

Purpose
Healthy diets are believed to be associated with a reduced risk of experiencing common mental disorders (CMDs) and related symptomatology (such as ruminative thinking), and with healthier brain chemistry and structure, especially in the frontal regions implicated in CMDs, cognitive control, and food choice. Nevertheless, there is very limited research on the relationship between diet health/quality and brain function. In this study we assessed the associations between adherence to the Mediterranean diet and resting state functional connectivity (rs-FC) of the prefrontal cortex (PFC) with the whole brain and whether this connectivity would be associated with ruminative thinking as a transdiagnostic factor for CMDs.

Methods
Thirty-seven adults (Mean Age = 25.57, SD = 7.18) completed the Mediterranean Diet Adherence Screener (MEDAS) and were classified into high- and low-quality diet groups and completed the Ruminative Response Scale. All participants underwent resting-state functional MRI (fMRI) to determine whole-brain rs-FC of the medial prefrontal cortex (mPFC).

Results
Participants in the high MEDAS group (vs. low MEDAS group) exhibited significantly greater rs-FC of the mPFC seed with the thalamus, caudate and putamen. Additionally, the strength of rs-FC of the mPFC seed with these regions was positively associated with the MEDAS scores across groups in both crude and adjusted models. There were no significant associations between the strength of rs-FC of the mPFC seed with the cluster of voxels with the thalamus, caudate, and putamen and ruminative thinking.

Discussion
This work shows that healthy dietary patterns are associated with rs-FC in the frontal-subcortical circuitry in healthy volunteers. Considering the implications of the dysregulation of this circuity, adhering to healthy dietary patterns may offer a promising alternative/complementary method to improve CMDs, cognitive control, and food choices.
Phase transition for random walks on graphs with added weighted random matching
Authors: Baran Zsuzsanna , Hermon Jonathan , Šarković Anđela , Sousi Perla 
Published: November 2024

AbstractFor a finite graph $$G=(V,E)$$

G
=
(
V
,
E
)

let $$G^*$$

G
∗

be obtained by considering a random perfect matching of V and adding the corresponding edges to G with weight $$\varepsilon $$
ε
, while assigning weight 1 to the original edges of G. We consider whether for a sequence $$(G_n)$$

(

G
n

)

of graphs with bounded degrees and corresponding weights $$(\varepsilon _n)$$

(

ε
n

)

, the (weighted) random walk on $$(G_n^*)$$

(

G
n
∗

)

has cutoff. For graphs with polynomial growth we show that $$\log \left( \frac{1}{\varepsilon _n}\right) \ll \log |V_n|$$

log

1

ε
n

≪
log

|

V
n

|

is a sufficient condition for cutoff. Under the additional assumption of vertex-transitivity we establish that this condition is also necessary. For graphs where the entropy of the simple random walk grows linearly up to some time of order $$\log |V_n|$$

log
|

V
n

|

we show that $$\frac{1}{\varepsilon _n}\ll \log |V_n|$$

1

ε
n

≪
log

|

V
n

|

is sufficient for cutoff. In the special case of expander graphs we also provide a complete picture for the complementary regime $$\frac{1}{\varepsilon _n}\gtrsim \log |V_n|$$

1

ε
n

≳
log

|

V
n

|

.
Tilde, an interdisciplinary data access solution serving GeoNet’s volcano and other hazard data
Authors: D’Anastasio Elisabetta , Groom Joshua , Sherburn Steven , Houltham Jeremy , Chadwick Mark , Morris Callum , Peng Baishan , Wu Howard , Harvey Sue , Hanson Jonathan B. ,   GeoNet team
Published: November 2024

AbstractTilde is a new in-house developed solution that the GNS Science’s GeoNet program has recently developed to provide storage and access to low sample rate datasets used to monitor tsunami, landslides, and volcanoes in Aotearoa New Zealand. It includes datasets covering sample rates of 15 s or longer. Time series data are stored and disseminated in JSON and CSV formats, and users can access these through an application programming interface (API) and through graphical user interfaces (GUIs). Tilde’s GUIs were created to allow technical and non-technical users easy access to the available data. The introduction of the Tilde system as one of the GeoNet program delivery channels has represented a big step forward for GeoNet’s volcano data holdings by providing a single point to access all low to medium-sample rate volcano-specific monitoring data. We designed the system and developed a domain model, an API, a graphical data discovery interface, and associated data tutorials. This work leverages the open-by-default data policy for data generated through the GeoNet program. This paper is intended to highlight how we made many of the key decisions that shaped the Tilde system, how they were impacted by our multi-hazard monitoring requirements, and how they have improved access to volcano monitoring data. We conclude with some open questions about the need to develop common standards to share analysis-ready time series data within different disciplines in volcanology and geophysics.
Anti-integrin αvβ6 antibody as a biomarker for diagnosing ulcerative colitis: a nationwide multicenter validation study
Authors: Okabe Makoto , Yamamoto Shuji , Shiokawa Masahiro , Hisamatsu Tadakazu , Yamazaki Hajime , Nakanishi Risa , Hamada Kensuke , Kitamoto Hiroki , Kuwada Takeshi , Uza Norimitsu , Sakatani Aki , Fujii Toshimitsu , Ohno Masashi , Matsuura Minoru , Shibuya Tomoyoshi , Ohmiya Naoki , Ooi Makoto , Hoshi Namiko , Moriya Kei , Tsuchiya Kiichiro , Yamaguchi Yoshiharu , Kunisaki Reiko , Takahara Masahiro , Takagi Tomohisa , Takehara Tetsuo , Hirai Fumihito , Kakimoto Kazuki , Esaki Motohiro , Nakase Hiroshi , Kinjo Fukunori , Torisu Takehiro , Kanmura Shuji , Narimatsu Kazuyuki , Matsuoka Katsuyoshi , Hiraga Hiroto , Yokoyama Kaoru , Honzawa Yusuke , Naganuma Makoto , Saruta Masayuki , Kodama Yuzo , Chiba Tsutomu , Seno Hiroshi 
Published: November 2024

Abstract
Background
A serum biomarker for diagnosing ulcerative colitis (UC) remains to be established. Although we recently reported an anti-integrin αvβ6 antibody (V6 Ab) for diagnosing UC with high sensitivity and specificity, no large-scale validation study exists. This study aimed to validate the diagnostic value of V6 Ab for UC using a nationwide multicenter cohort study.

Methods
We measured V6 Ab titers in patients definitively diagnosed with UC, Crohn’s disease (CD), or other gastrointestinal disorders (OGDs). The primary outcome was the diagnostic value of V6 Ab. Secondary outcomes were factors associated with false-negative results in patients with UC and false-positive results in patients without UC and the heterogeneity of the diagnostic value of V6 Ab among the participating facilities.

Results
We enrolled 1241, 796, and 206 patients with UC, CD, and OGD, respectively, from 28 Japanese high-volume referral centers. The diagnostic sensitivity of V6 Ab for UC was 87.7%, and its specificities for CD and OGDs were 82.0% and 87.4%, respectively. Multivariable logistic regression analysis showed that false-negative results were associated with older age at the time of sample collection, current smokers, lower partial Mayo score, and not receiving advanced therapies in patients with UC, and false-positive results were associated with colonic CD in patients with CD. No factor was associated with false-positive results in patients with OGDs. There were no significant differences in the diagnostic value of V6 Ab among the centers.

Conclusions
The diagnostic value of V6 Ab for UC was validated in the large-scale nationwide multicenter study.