bluuebunny/crossref_metadata_2025_split huggingface dataset:
The European Federation of Clinical Chemistry and Laboratory Medicine syllabus for postgraduate education and training for Specialists in Laboratory Medicine: version 5 – 2018
Authors: Jassam Nuthar , Lake Jennifer , Dabrowska Milena , Queralto Jose , Rizos Demetrios , Lichtinghagen Ralf , Baum Hannsjörg , Ceriotti Ferruccio , O’Mullane John , Homšak Evgenija , Charilaou Charis , Ohlson Mats , Rako Ivana , Vitkus Dalius , Kovac Gustav , Verschuure Pauline , Racek Jaroslav , Chifiriuc Mariana Carmen , Wieringa Gilbert 
Published: October 2018

AbstractAlthough laboratory medicine practise varies across the European Union’s (EU) member states, the extent of overlap in scope is such that a common syllabus describing the education and training associated with high-quality, specialist practise can be identified. In turn, such a syllabus can help define the common set of skills, knowledge and competence in a Common Training Framework (CTF) for non-medical Specialists in Laboratory Medicine under EU Directive 2013/55/EU (The recognition of Professional Qualifications). In meeting the requirements of the directive’s CTF patient safety is particularly enhanced when specialists seek to capitalise on opportunities for free professional migration across EU borders. In updating the fourth syllabus, the fifth expands on individual discipline requirements, new analytical techniques and use of statistics. An outline structure for a training programme is proposed together with expected responsibilities of trainees and trainers; reference is provided to a trainee’s log book. In updating the syllabus, it continues to support national programmes and the aims of EU Directive 2013/55/EU in providing safeguards to professional mobility across European borders at a time when the demand for highly qualified professionals is increasing in the face of a disparity in their distribution across Europe. In support of achieving a CTF, the syllabus represents EFLM’s position statement for the education and training that underpins the framework.
Quantification of slip planes in the stem wood ofEucalyptus grandis
Authors: Moulin Jordão Cabral , Lima José Tarcísio 
Published: October 2018

AbstractThe objective of this work was to analyze the natural occurrence of slip planes (SPs) inEucalyptus grandiswood fibers in terms of their characterization, distribution in the stem and associations with other wood characteristics. A 28-year-oldE. grandiswas studied, whose stems were sampled in the base-top direction. The longitudinal compressive stress regions (LCompSR, in the inner part of the stem) and longitudinal tensile stress region (LTensSR, in the outer parts of the stem) were separately considered. The following parameters were measured: microfibril angle (MFA), slip plane angle (SPA), number of SPs per millimeter (SP mm−1), slip plane index (SPI) and the relative abundance of SP in the fiber. The SPAs differ only slightly between LCompSR (76°) and LTensSR (77°). The base of the stem, which supports a larger mass, contains the most SPs and the number of SPs decreases from the base to the top. In the LCompSR, the SPI reduction was from 21 to 8%, and in the LTensSR, from 18 to 7%.
FAM134B promotes adipogenesis by increasing vesicular activity in porcine and 3T3-L1 adipocytes
Authors: Cai Min , Chen Jin , Yu Caihua , Xi Lingling , Jiang Qin , Wang Yizhen , Wang Xinxia 
Published: October 2018

Abstract
Family with sequence similarity 134, Member B (FAM134B), is a cis-Golgi transmembrane protein that is known to be necessary for the long-term survival of nociceptive and autonomic ganglion neurons. Recent work has shown that FAM134B plays a pivotal role in autophagy-mediated turnover of endoplasmic reticulum (ER) membranes, tumor inhibition and lipid homeostasis. In this study, we provide mechanistic links between FAM134B and ARF-related protein 1 (ARFRP1) and further show that FAM134B resides in the Golgi apparatus. Here, we found that FAM134B increased lipid accumulation in adipocytes. Transport vehicle number and ADP-ribosylation factor (ARF) family gene expression were also increased by FAM134B overexpression, suggesting that vesicular transport activity enhanced lipid accumulation. ARF-related protein 1 (ARFRP1) is a GTPase that promotes protein trafficking. We show that FAM134B regulates the expression of ARFRP1, and the knockdown of ARFRP1 abolishes enhancement on lipid accumulation caused by FAM134B. In addition, FAM134B upregulates the PAT family protein (PAT), which associates with the lipid droplets (LDs) surface and promotes lipolysis by recruiting adipocyte triglyceride lipase (ATGL). These findings indicate that FAM134B promotes lipid accumulation and adipogenic differentiation by increasing vesicle transport activity in the Golgi apparatus and inhibiting the lipolysis of LDs.
Formylglycine-generating enzymes for site-specific bioconjugation
Authors: Krüger Tobias , Dierks Thomas , Sewald Norbert 
Published: October 2018

Abstract
Site-specific bioconjugation strategies offer many possibilities for directed protein modifications. Among the various enzyme-based conjugation protocols, formylglycine-generating enzymes allow to posttranslationally introduce the amino acid Cα-formylglycine (FGly) into recombinant proteins, starting from cysteine or serine residues within distinct consensus motifs. The aldehyde-bearing FGly-residue displays orthogonal reactivity to all other natural amino acids and can, therefore, be used for site-specific labeling reactions on protein scaffolds. In this review, the state of research on catalytic mechanisms and consensus motifs of different formylglycine-generating enzymes, as well as labeling strategies and applications of FGly-based bioconjugations are presented.
Message exchange on base of a blockchain-based layered architecture
Authors: Roth Uwe , Ngne Djoua Theophane 
Published: October 2018

Abstract
In this article, we propose an architecture that allows to exchange messages or data via a blockchain solution, while keeping the business process independent from the concrete blockchain. The project is the consequence of a need to have fast development of a blockchain based proof of concept that shows the feasibility of a business process, while knowing that in a future step the underlying blockchain solution has to be replaced for reasons of licensing or maximal data throughput. This is done by providing an architecture on base of layers, similar to the OSI-model, and encapsulates the used blockchain within a wrapper layer that covers all blockchain specific properties and only provides a transparent view on the reading or writing from and to the blockchain. The higher layers re-implement point-to-point communication and introduce confidentiality by the use of encryption techniques. The architecture has been tested and proven by implementing two different blockchain solutions that are shielded by specific wrapper layer implementations. This wrapper layer is responsible for the fragmentation of the sent data and their encapsulation into the concrete blockchain solution. The reconstruction of the data takes care of the data fragments being sent potentially out of order or being incomplete. A payload layer is introduced to provide point-to-point communication and to embed the main message inside a message structure. In collaboration with underlying layer it identifies for which message one is not the addressee and allow the underling layer to stop collecting unnecessary data. A crypto-layer finally provides ways of encrypting messages for one or many recipients. Having fixed layers not only allows to replace the underlying blockchain solution but also to extend or replace the other layers in case new security features or optimized protocols need to embedded. The proposed solution does not allow to use specific features like smart contracts and only provides undeniable tamper-proofed existence of a sent message.
The Berlin Big Data Center (BBDC)
Authors: Boden Christoph , Rabl Tilmann , Markl Volker 
Published: October 2018

Abstract
The last decade has been characterized by the collection and availability of unprecedented amounts of data due to rapidly decreasing storage costs and the omnipresence of sensors and data-producing global online-services. In order to process and analyze this data deluge, novel distributed data processing systems resting on the paradigm of data flow such as Apache Hadoop, Apache Spark, or Apache Flink were built and have been scaled to tens of thousands of machines. However, writing efficient implementations of data analysis programs on these systems requires a deep understanding of systems programming, prohibiting large groups of data scientists and analysts from efficiently using this technology. In this article, we present some of the main achievements of the research carried out by the Berlin Big Data Cente (BBDC). We introduce the two domain-specific languages Emma and LARA, which are deeply embedded in Scala and enable declarative specification and the automatic parallelization of data analysis programs, the PEEL Framework for transparent and reproducible benchmark experiments of distributed data processing systems, approaches to foster the interpretability of machine learning models and finally provide an overview of the challenges to be addressed in the second phase of the BBDC.
Calculating Gross Hourly Wages – the (Structure of) Earnings Survey and the German Socio-Economic Panel in Comparison
Authors: Dütsch Matthias , Himmelreicher Ralf , Ohlert Clemens 
Published: October 2018

Abstract
The statutory minimum wage in Germany was set as an hourly wage. Thus, valid information on gross hourly wages must be calculated from monthly wages and weekly working hours. This paper compares the German Socio-Economic Panel (GSOEP) and the (Structure of) Earnings Survey (SES/ES). The sampling and collection of data on employees in the household survey GSOEP, and on jobs in the administrative surveys SES/ES exhibit fundamental conceptual differences. Accordingly, there is variation in the definition of types of employment and in the distribution of the observed units regarding central characteristics. Monthly wages, weekly working hours and gross hourly wages differ especially in the lower range of the respective distribution. Against this backdrop specific implications can be derived for minimum wage research.
Crystal structure of (2E,4Z)-dimethyl 4-((phenylamino)methylene)pent-2-enedioate, C14H15N1O4
Authors: Chen Xiao-Ming , Zhang Xing-Yu , He Fu-Lin , Pan Jun , Jia Guo-Kai 
Published: October 2018

Abstract
C14H15N1O4, triclinic, P1̄, a = 8.2018(4) Å, b = 11.5512(5) Å, c = 14.4121(7) Å, α = 79.242(2)°, β = 78.647(3)°, γ = 85.496(3)°, V = 1313.93(11) Å3, Z = 2, R
gt(F) = 0.0548, wR
ref(F
2) = 0.1805, T = 296(2) K.
Crystal structure of 2-(furan-2-yl)-5-methyl-1,3-dioxane-5-carboxylic acid, C10H12O5
Authors: Yuan Lin , Yuan Xian-You , Li Zhong-Yan 
Published: October 2018

Abstract
C10H12O5, monoclinic, P21/c (no. 14), a = 5.6706(16) Å, b = 32.091(9) Å, c = 6.5636(14) Å, β = 123.733(17)°, V = 993.3(5) Å3, Z = 4, R
gt(F) = 0.0359, wR
ref(F
2) = 0.0893, T = 296(2) K.
Potential of hyperspectral imaging to detect and identify the impact of chemical warfare compounds on plant tissue
Authors: Kuska Matheus Thomas , Behmann Jan , Mahlein Anne-Katrin 
Published: October 2018

Abstract
The OPCW Member states cover 98% of the global population and landmass. Regrettably, unanticipated chemical warfare agent assaults are reported during the last decades. In addition to the frequent threat situation, the sampling of bio-medical samples from these areas is critical and mainly depends on investigation opportunities of victims. Non-contact sensor technologies are desirable to enable a fast and secure estimation of a situation. Plants react on pollution because of their direct interaction with gases and it is assumed that chemical warfare agents influence plants, respectively. This impact can be analyzed for the detection and characterization of chemical warfare assaults. Nowadays technological progress in digital technologies provides new innovations in detectors, data analysis approaches and software availability which could improve the screening, monitoring and analysis of chemical warfare. Within this context hyperspectral imaging (HSI) is a promising method. Different applications from remote to close range sensing in medicine, food production, military, geography and agriculture do exist already. During the last years HSI showed high potential to determine and assess different plant parameters, e.g. abiotic and biotic stresses by recording the spectral reflectance of plants. Within the present manuscript, the basics principle of HSI as an innovative technique, aspects of recording and analyzing HSI data is presented using wild growing apple leaves which are treated with sulfuric acid, fire or heat. Resulting spectral signatures showed significant changes among the treatments. Especially the shortwave infrared was sensitive to changes due to the different treatments. Furthermore, the calculation of common spectral indices revealed differences due to the treatments which are not visible to the human eye. The results support HSI applications for the detection of chemical warfare agents and elucidate the impact of chemical warfare on plants.
Rats selectively bred for showing divergent behavioral traits in response to stress or novelty or spontaneous yawning with a divergent frequency show similar changes in sexual behavior: the role of dopamine
Authors: Melis Maria Rosaria , Sanna Fabrizio , Argiolas Antonio 
Published: October 2018

Abstract
Sexual behavior plays a fundamental role for reproduction in mammals and other animal species. It is characterized by an anticipatory and a consummatory phase, and several copulatory parameters have been identified in each phase, mainly in rats. Sexual behavior varies significantly across rats even when they are of the same strain and reared under identical conditions. This review shows that rats of the same strain selectively bred for showing a divergent behavioral trait when exposed to stress or novelty (i.e. Roman high and low avoidance rats, bred for their different avoidance response to the shuttle box, and high and low novelty exploration responders rats, bred for their different exploratory response to a novel environment) or a spontaneous behavior with divergent frequency (i.e. low and high yawning frequency rats, bred for their divergent yawning frequency) show similar differences in sexual behavior, mainly in copulatory pattern, but also in sexual motivation. As shown by behavioral pharmacology and intracerebral microdialysis experiments carried out mainly in Roman rats, these sexual differences may be due to a more robust dopaminergic tone present in the mesocorticolimbic dopaminergic system of one of the two sub-lines (e.g. high avoidance, high novelty exploration, and low yawning rat sub-lines). Thus, differences in genotype and/or in prenatal/postnatal environment lead not only to individual differences in temperament and environmental/emotional reactivity but also in sexual behavior. Because of the highly conserved mechanisms controlling reproduction in mammals, this may occur not only in rats but also in humans.
Üst gis endoskopi yapılacak hastalarda alarm semptom varlığı ile organik patoloji arasındaki prediksiyon çalışması
Authors: BİLEN Aslı , DEMİRDAĞ Hakan , ERDEM Emrullah , COŞGUN Süleyman , DEMİRTUNÇ Refik 
Published: October 2018

Giriş ve Amaç: Dispepsili genç hastalarda alarm semptomlarının olmaması
malignite yokluğuna dair güvenilir bir gösterge olarak kabul edilmektedir.
Ancak alarm semptomlarının pozitif prediktif değeri nispeten zayıf kalmaktadır.
Bu çalışmadaki amacımız alarm semptomlarının üst gastrointestinal
sistem maligniteleri için tanısal değerini ve alarm semptomlarının yanısıra
üst gastrointestinal sistem malignitelerini predikte eden farklı kriterlerler
olup olmadığını araştırmaktır. Gereç ve Yöntem: 01.07.2011 ile 15.12.2012
tarihleri arasında Haydarpaşa Numune EAH Endoskopi Ünitesi’ne çeşitli nedenlerle
üst gastrointestinal sistem endoskopisi yapılması amacıyla yönlendirilen
18-70 yaş arasında 200 hastaya hazırlamış olduğumuz anket yapılarak
alarm semptomlarının olup olmadığı sorgulandı. Herhangi bir alarm semptomu
varlığının ve tek tek alarm semptomlarının üst gastrointestinal sistem
malignite prediksiyonu açısından duyarlılıkları, seçicilikleri, pozitif prediktif
değerleri ve negatif prediktif değerleri hesaplandı. Bulgular: Çalışmada üst
gastrointestinal sistem malignite prevalansı %3.5 olarak bulundu. Malignite
görülen olguların tamamında herhangi bir alarm semptomu tespit edilirken,
malignitesi olmayan olgularda alarm semptomu görülme oranı %91.2 idi.
Herhangi bir alarm semptomu varlığının ve her bir alarm semptomunun
pozitif prediktif değeri düşük, negatif prediktif değeri yüksek saptandı. Maligniteli
olguların %28’i iyi differansiye, %28’i orta differansiye, %44’ü az
differansiye idi. Üst gastrointestinal sistem malignitesi ile kilo kaybı olan ve
sarılık, abdominal kitle ya da lenfadenopati olan olgular arasında istatistiksel
açıdan anlamlı ilişki saptandı. Malignite tanısına 45 yaş ve üstünde olmak,
disfaji, kilo kaybı, anoreksi, sarılık ve gastrik cerrahi öykü parametrelerinin
etkilerini lojistik regresyon analizi ile değerlendirdiğimizde malignite
ile ilişkileri istatistiksel olarak anlamlı (p: 0.002; p&lt;0.01) bulundu. Sonuç:
Sonuç olarak, bulgularımız alarm semptomlarının tanısal değerinin optimal
olmadığını gösterdi. En etkin (alarm semptomları ve diğer faktörlerin) kombinasyonun
tanımlanması için daha geniş olgu serilerine sahip çalışmalara
ihtiyaç vardır.
When Citizens Are Minority: Toward Establishing A Comprehensive Emirati SME Support System
Authors: Abdelkarim Abbas 
Published: October 2018

This paper endeavours to contribute to developing a comprehensive framework of institutional support system in a situation where citizens and citizen-owned SMEs form a minority in their own country. This is significant because it is not confined only to the case study of this Paper, (United Arab Emirates), but is prevalent in all countries of Gulf Cooperation Council.
Examining the current situation of Emirati-owned SME reveals many challenges and opportunities. After developing an empirical framework for SME support and providing analysis of the Emirati SME scene, the paper uses the benchmarking approach (and Singapore has been selected for this purpose), and refers to other relevant literature, to discuss and develop constituents of the proposed support system. It concludes that Emirati SME support system may not be sustainable if not linked to a broader strategy for the development of the country’s entire SME sector. Such a strategy, which the paper has not extended into, remains to be an area for future research.
HAK ATAS DERAJAT PELAYANAN KESEHATAN YANG OPTIMAL
Authors: Hidayat Rif'atul 
Published: October 2018

Adanya pengakuan baik menurut Hukum Nasional maupun Hukum Internasional terhadap hak atas kesehatan tidak berarti masyarakat mempunyai hak untuk sehat. Siapapun pada dasarnya tidak mampu menjamin suatu kondisi kesehatan tertentu, baik Pemerintah maupun masyarakat. Kondisi kesehatan individu lebih banyak dipengaruhi oleh faktor lingkungan tempat tinggal dan keturunan. Definisi-definisi hak atas kesehatan yang digunakan dalam instumen-instrumen hak asasi manusia seperti yang telah dikemukakan, umumnya mengacu pada “derajat kesehatan tertinggi yang dapat dicapai” (the highest attainable standard of health) sebagai sasaran hak atas kesehatan. Oleh karena itu substansi hak atas kesehatan sangat relatif, karena derajat tertinggi yang dapat dicapai tersebut dapat bervariasi sesuai waktu dan tempat.
Perfil del docente de práctica clínica en odontología desde la perspectiva del estudiante y del docente de una universidad privada
Authors: Fukuhara Mary , Castro Alicia , Flores Mirza 
Published: October 2018

Objetivos: Determinar el perfil del docente de práctica clínica en odontología desde la perspectiva del estudiante y del docente en la Facultad de Estomatología de la Universidad Peruana Cayetano Heredia. Material y métodos: La investigación fue de naturaleza cuantitativa, descriptiva, no experimental. Para recolectar los datos se utilizó una encuesta y se aplicó un cuestionario tipo escala de Likert validada, estructurada en seis dimensiones a 177 estudiantes y a 44 docentes que participan en los cursos clínicos. Resultados: Se encontró que de las seis di- mensiones consideradas para el perfil, el estudiante consideró como muy importantes (87%) las características y comportamientos del docente agrupadas en la dimensión Disponibilidad del docente en la clínica y la fundamen- tación de la actividad clínica es la de menor importancia (74,6%), a diferencia de lo observado en los docentes quienes consideraron que las características y comportamientos de los docentes de la dimensión fundamentación de la actividad clínica es lo más importante (97,7%) y las de menor importancia las dimensiones metodología utilizada por el docente y la dimensión disponibilidad del docente en la clínica, ambas con un 84,1%. Encontrándose una diferencia estadísticamente significativa (p<0,001) en la dimensión fundamentación de la actividad clínica. Conclusiones: El perfil del docente de práctica clínica desde la perspectiva del estudiante y del docente es diferente, mostrando una diferencia significativa en la dimensión fundamentación de la actividad clínica.
Índice de caries y de higiene oral en un grupo de pacientes autistas
Authors: Morales-Chávez Mariana , Villarroel-Dorrego Mariana 
Published: October 2018

Objetivos: Determinar el Índice de Caries CPO-D, ceo-d y el Índice de Higiene Oral Simplificado en un grupo de pacientes autistas y controles sanos. Materiales y Métodos: Se realizó un estudio observacional transversal donde se seleccionaron 34 autistas y 34 niños sanos de género masculino entre 4 y 13 años. Se determinó el índice CPOD y el IHO-S. Todos los datos fueron analizados con el programa estadístico SPSS a través de la prueba de chi cuadrado y el test de Student para muestras independientes. Resultados: El 20,60 % de los pacientes autistas y el 73,50% de los controles presentaban caries (p≤0,001), siendo el Índice CPO-D de 1±1 y ceo-d de 0 en los pacientes autistas y 3±2 y 0 en los controles (p≤0,001). En relación al IHO-S, los valores fueron de 2,25±0,78 en los pacientes autistas y de 1.79±0,59 en los controles (p=0,008). Conclusiones:Los índices de caries fueron menores en los pacientes autistas y los Índices de Higiene Oral fueron mayores.