bluuebunny/crossref_metadata_2025_split huggingface dataset:
Group B rotavirus encodes a functional fusion-associated small transmembrane (FAST) protein
Authors: Diller Julia R. , Parrington Helen M. , Patton John T. , Ogden Kristen M. 
Published: May 2019

ABSTRACTRotavirus is an important cause of diarrheal disease in young mammals. Group A rotavirus (RVA) causes most human rotavirus diarrheal disease and primarily affects infants and young children. Group B rotavirus (RVB) has been associated with sporadic outbreaks of human adult diarrheal disease. RVA and RVB are predicted to encode mostly homologous proteins but differ significantly in the proteins encoded by the NSP1 gene. In the case of RVB, the NSP1 gene encodes two putative protein products of unknown function, NSP1-1 and NSP1-2. We demonstrate that human RVB NSP1-1 mediates syncytia formation in cultured human cells. Based on sequence alignment, NSP1-1 from groups B, G, and I contain features consistent with fusion-associated small transmembrane (FAST) proteins, which have previously been identified in otherReoviridaeviruses. Like some other FAST proteins, RVB NSP1-1 is predicted to have an N-terminal myristoyl modification. Addition of an N-terminal FLAG peptide disrupts NSP1-1-mediated fusion, consistent with a role for this fatty-acid modification in NSP1-1 function. NSP1-1 from a human RVB mediates fusion of human cells but not hamster cells and, thus, may serve as a species tropism determinant. NSP1-1 also can enhance RVA replication in human cells, both in single-cycle infection studies and during a multi-cycle time course in the presence of fetal bovine serum, which inhibits rotavirus spread. These findings suggest potential yet untested roles for NSP1-1 in RVB species tropism, immune evasion, and pathogenesis.IMPORTANCEWhile group A rotavirus is commonly associated with diarrheal disease in young children, group B rotavirus has caused sporadic outbreaks of adult diarrheal disease. A major genetic difference between group A and B rotaviruses is the NSP1 gene, which encodes two proteins for group B rotavirus. We demonstrate that the smaller of these proteins, NSP1-1, can mediate fusion of cultured human cells. Comparison with viral proteins of similar function provides insight into NSP1-1 domain organization and fusion mechanism. Our findings are consistent with an important role for a fatty acid modification at the amino terminus of the protein in mediating its function. NSP1-1 from a human virus mediates fusion of human cells, but not hamster cells, and enhances rotavirus replication in culture. These findings suggest potential, but currently untested, roles for NSP1-1 in RVB species tropism, immune evasion, and pathogenesis.
How does task-technology fit influence cloud-based e-learning continuance and impact?
Authors: Cheng Yung-Ming 
Published: May 2019

PurposeAccording to expectation–confirmation model (ECM) and task-technology fit (TTF) model, the purpose of this paper is to examine the role of TTF in students’ cloud-based e-learning continuance and evaluate whether TTF affects students’ perceived impact on learning of the cloud-based e-learning system within the educational institution.Design/methodology/approachSample data for this study were collected from students enrolled in a comprehensive university in Taiwan. A total of 500 questionnaires were distributed in the campus, and 391 (78.2 percent) usable questionnaires were analyzed using structural equation modeling in this study.FindingsThis study’s results verified that both task characteristics and technology characteristics affected students’ perceived TTF, which significantly contributed to their perceived usefulness, confirmation and satisfaction with the cloud-based e-learning system, and these in turn directly or indirectly led to their continuance intention of the system and perceived impact on learning; essentially, the results strongly supported the research model integrating ECM and TTF model via positioning key constructs as the drivers with all hypothesized links being significant.Originality/valueThis study contributes to an understanding of the TTF in explaining students’ cloud-based e-learning continuance that is difficult to explain with only their utilitarian perception of the cloud-based e-learning system, and further places considerably more emphasis upon students’ perceived impact on learning greatly driven by their TTF in the system. Thus, this study’s empirical evidence on incorporating ECM and TTF model can shed light on the outcome for cloud-based e-learning continuance and enhance better understanding of a richer post-adoption model.
The health challenges of families experiencing homelessness
Authors: Annor Bridget Osei Henewaah , Oudshoorn Abe 
Published: May 2019

Purpose
The purpose of this paper is to report the findings of a scoping review on the health challenges of families experiencing homelessness. There is a bi-directional relationship between health and homelessness in that poor health can increase the risk of housing loss, and experiencing homelessness is bad for one’s health. The experience of homelessness differs between populations and this review focuses on families as one of the fastest growing segments of the homeless population. While research has been integrated on the causes of homelessness for families, this same integration has not been conducted looking at health challenges of families experiencing homelessness.

Design/methodology/approach
A scoping review methodology is utilized in the paper. As the goal of this work is to ultimately develop interventions for a Canadian context, primacy is given to Canadian sources, but other relevant literature is also included.

Findings
A clear distinction is seen in the literature between health challenges of children of homeless families and health challenges of parents. These themes are explored separately, and preliminary recommendations are made for potential points of intervention as personal, program and policy levels.

Originality/value
This review of current evidence is an important first step in building a foundation for interventions to improve health outcomes for those experiencing housing loss.
Illuminating undergraduate experiential and situated learning in podiatry clinical placement provision at a UK school of podiatric medicine
Authors: Hayes Catherine , Bussey Sonia , Graham Yitka 
Published: May 2019

Purpose
Situated and experiential learning methodologies are largely underresearched in relation to student experience and satisfaction. The purpose of this paper is to illuminate the perspectives of students studying on a BSc (Hons) Podiatry degree programme to establish perceptions of their experience in practice.

Design/methodology/approach
Using an interpretivist methodological framework, Free Association Narrative Interviewing was used to provide an insight into the perceived impact that experiential learning in clinical placements had on undergraduate podiatry students.

Findings
Students perceived that what could not be taught but what could be experienced, contributed much to the confidence that students had gained during their training and which they anticipated would be further developed during the initial years of their training in practice, particularly in the context of the NHS.

Research limitations/implications
This is a study from which it is acknowledged that within the underpinning research design and methodology there is no scope for generalisability.

Practical implications
The study highlights an appreciation for the implication and recognition of “tacit” knowledge, currently recognised in medical curricula as an asset which can aid a move towards higher order critical thinking skills.

Social implications
Student acknowledgement of the need for emphasis on “soft skills” can be posited, in the context of this small-scale study as an appreciation for affective domain learning in the context of podiatric academic and clinical curricula.

Originality/value
Limited information from the extant literature is available in relation to the illumination of podiatry student placement experiences, so this research contributes to an effectively underresearched field.
Family-to-work spillover effects of family incivility on employee sabotage in the service industry
Authors: Cheng Bao , Zhou Xing , Guo Gongxing 
Published: May 2019

PurposeThis study aims to explore family incivility as a source of stress originating in the family domain and empirically examine its spillover effects on the workplace.Design/methodology/approachThrough integrating the work–family interface model with conservation of resources (COR) theory, this study investigated the effect of family incivility as perceived by employees of the service industry on service sabotage, along with the mediating role of family-to-work conflict (FWC) and the moderating role of work–family centrality.FindingsThe results of a three-wave survey of 335 employees in China and 62 of their immediate supervisors demonstrated that family incivility was positively related to service sabotage, and FWC also mediated this relationship. Moreover, work–family centrality was found to strengthen the effect of family incivility on FWC, as well as the mediating effect of FWC on the relationship between family incivility and service sabotage.Research limitations/implicationsThis study not only enriched the work–family interface literature but also suggested new insights into sabotage behaviors by focusing on antecedents in the family domain.Practical implicationsBy realizing that family incivility has detrimental effects on service employee behaviors, enterprises and managers should provide greater support for employees in managing family incivility and help them to maintain a better balance between work and family life.Originality/valueThis study appears to be the first empirical evidence linking a family stressor (i.e. family incivility) with a workplace behavioral outcome in the service industry (i.e. service sabotage).
Does country-of-origin matter in the era of globalisation? Evidence from cross sectional data in Uzbekistan
Authors: Karimov Farhod , El-Murad Jaafar 
Published: May 2019

Purpose
The purpose of this paper is to examine the consistency over time of customer attitude towards country-of-origin in a transitional economy.

Design/methodology/approach
A single cross-sectional study in Uzbekistan was carried out, with n=527, consisting of 374 street and 153 online surveys, replicating a study carried out 20 years earlier.

Findings
Whilst consumers still perceive products from advanced countries to have higher quality, quality perception in relation to country-of-origin information is dynamic and transitional countries can improve the perception of consumers towards their national brands.

Research limitations/implications
This study was carried out in Tashkent, the capital of Uzbekistan, the most populous of the Central Asian republics. Researchers may wish to extend it by examining COO effects in other transitional economies, and additionally to examine the effect of country-of-brand origin.

Practical implications
Customer perceptions and attitudes take a long-time to evolve. This cross-sectional study showed that the COO perception of China has improved significantly and the perception towards the products produced locally in Uzbekistan has also slightly improved across all categories. Strong brands can contribute to the image of the country. Transition countries need to take appropriate marketing actions to cultivate positive perception through innovation and branding.

Originality/value
Prior research has been extended by adding new product categories such as mobile phones, computers, washing machines and air conditioners. This research shows that government officials and exporters in developing countries should prioritise strengthening their country’s image to help domestic marketers export and attract foreign investors. The authors provide insights for marketers to understand the impact of product country-of-origin on customer purchase intention and its antecedents in transitional economies, such as Uzbekistan.
Blockchain technology: implications for operations and supply chain management
Authors: Cole Rosanna , Stevenson Mark , Aitken James 
Published: May 2019

PurposeThis paper aims to encourage the study of blockchain technology from an operations and supply chain management (OSCM) perspective, identifying potential areas of application, and to provide an agenda for future research.Design/methodology/approachAn explanation and analysis of blockchain technology is provided to identify implications for the field of OSCM.FindingsThe hype around the opportunities that digital ledger technologies offer is high. For OSCM, a myriad of ways in which blockchain could transform practice are identified, including enhancing product safety and security; improving quality management; reducing illegal counterfeiting; improving sustainable supply chain management; advancing inventory management and replenishment; reducing the need for intermediaries; impacting new product design and development; and reducing the cost of supply chain transactions. The immature state of practice and research surrounding blockchain means there is an opportunity for OSCM researchers to study the technology in its early stages and shape its adoption.Research limitations/implicationsThe paper provides a platform for new research that addresses gaps in knowledge and advances the field of OSCM. A research agenda is developed around six key themes.Practical implicationsThere are many opportunities for organisations to obtain an advantage by making use of blockchain technology ahead of the competition, enabling them to enhance their market position. But it is important that managers examine the characteristics of their products, services and supply chains to determine whether they need or would benefit sufficiently from the adoption of blockchain. Moreover, it is important that organisations build human capital expertise that allows them to develop, implement and exploit applications of this technology to maximum reward.Originality/valueThis is one of the first papers in a leading international OSCM journal to analyse blockchain technology, thereby complementing a recent article on digital supply chains that omitted blockchain.
Virtual social enterprise: modeling sustainability of an enterprise by digital intervention
Authors: Javed Asad , Yasir Muhammad 
Published: May 2019

Purpose
Social enterprises (SEs) have emerged as a tool to sustainable development. SEs create a social value along with an economic value. However, the aspect of SEs still missing from literature is the process of virtualization. The purpose of this paper is to introduce international social entrepreneurship as an emerging form of social entrepreneurship that is using information and communication technology (ICT)-enabled innovation and networking with international partners as virtual enterprise network, to create social and economic values across the borders.

Design/methodology/approach
In this paper, qualitative research paradigm is adopted to study the internationalization of SEs. To identify the drivers of internationalization, in-depth literature review was conducted. Articles from six databases and Google Scholar were searched to propose a comprehensive model for internationalization of SEs.

Findings
There is limited academic work on the use and impact of digital intervention (ICTs) on SEs and, especially, on the virtualization of SEs as there is no paper explaining virtualization of SEs. This paper proposes a model for the internationalization of SEs, named virtual social enterprise.

Research limitations/implications
The conceptual models and discussions on the virtualization of SEs are very limited in the extant literature. Very few articles could be found that studied the process of internationalization of SEs. Thus, the paper would have far-reaching implications for social enterprise theory and practice.

Originality/value
This is first study of its kind proposing a comprehensive theoretical model for internationalization of SEs. This model could be used by SEs for networking across international boundaries to control the flow of information and to market their products.
Switching on the light: using metagenomic shotgun sequencing to characterize the intestinal microbiome of Atlantic cod
Authors: Riiser Even Sannes , Haverkamp Thomas H.A. , Varadharajan Srinidhi , Borgan Ørnulf , Jakobsen Kjetill S. , Jentoft Sissel , Star Bastiaan 
Published: May 2019

SummaryAtlantic cod (Gadus morhua) is an ecologically important species with a wide‐spread distribution in the North Atlantic Ocean, yet little is known about the diversity of its intestinal microbiome in its natural habitat. No geographical differentiation in this microbiome was observed based on 16S rRNA amplicon analyses, yet such finding may result from an inherent lack of power of this method to resolve fine‐scaled biological complexity. Here, we use metagenomic shotgun sequencing to investigate the intestinal microbiome of 19 adult Atlantic cod individuals from two coastal populations in Norway–located 470 km apart. Resolving the species community to unprecedented resolution, we identify two abundant species, Photobacterium iliopiscarium and Photobacterium kishitanii, which comprise over 50% of the classified reads. Interestingly, the intestinal P. kishitanii strains have functionally intact lux genes, and its high abundance suggests that fish intestines form an important part of its ecological niche. These observations support a hypothesis that bioluminescence plays an ecological role in the marine food web. Despite our improved taxonomical resolution, we identify no geographical differences in bacterial community structure, indicating that the intestinal microbiome of these coastal cod is colonized by a limited number of closely related bacterial species with a broad geographical distribution.
Evaluating the stoichiometric trait distributions of cultured bacterial populations and uncultured microbial communities
Authors: Manzella Michael , Geiss Roy , Hall Ed K. 
Published: May 2019

SummaryWe measured the stoichiometric trait distribution of cultured freshwater bacterial populations under different resource conditions and compared them to natural microbial communities sampled from three lakes. Trait distributions showed population differences among growth phases and community differences among lakes that would have been masked by only reporting the mean biomass value. The stoichiometric trait distribution of the environmental isolates changed with P availability, growth phase and genotype, with P availability having the strongest effect. The distribution of biomass ratios within each isolate growth experiment were the most constrained during the stages of rapid growth and commonly had unimodal distributions. In contrast to the population distributions, the distribution of N:P and C:P for a similar number of cells from each of the lake communities had narrower stoichiometric distributions and more commonly exhibited multiple modes. © 2019 Society for Applied Microbiology and John Wiley & Sons Ltd
A Tale of Two Inquiries: Sans Everything and Ely
Authors: Hilton Claire 
Published: May 2019

AbstractThe government acknowledged scandalously poor care of long‐stay patients in National Health Service (NHS) hospitals in 1969. This followed the Ely Hospital inquiry, which emerged in the aftermath of revelations of abuse at seven hospitals described in Barbara Robb's book Sans Everything: A Case to Answer (1967). Allegations in Sans Everything and at Ely were similar. However, the inquiry committees which investigated, ‘disproved’ those in Sans Everything and upheld those at Ely. The Ely inquiry became pivotal to NHS policy reform for long‐stay mental illness and mental handicap hospitals, and for giving patients and their families a greater voice if they had concerns about inadequacies. This paper explains the relationship between Sans Everything and ‘Ely’ and analyses the impact of Robb's work—her high‐profile press campaign, networking, and determination to achieve improvement—which triggered revelations at Ely and elsewhere, and helped shape the course and constructive outcome of the Ely inquiry.
Economic performance of state‐owned enterprises under the Chinese Communist Party's supervision: Some reflection on China's economic reform
Authors: Hu Len‐Kuo , Lee Daniel C. 
Published: May 2019

AbstractThis study examines the economic behaviour of state‐owned enterprises in China with special emphasis on the role of the state's sole party as either an agent (management) or supervisor in the enterprises. It is found that with the construction of an incentive‐compatible compensation design and the Chinese Communist Party orchestrating an appropriate objective guideline for its members to follow, state or socialist capitalism could still achieve efficient economic performance. If party members did not behave prudently or pursued their personal interests instead of the state's overall welfare, there could be grave consequences, including corruption, nepotism or even the breakdown of the system.
Tax Deferral and Mutual Fund Inflows: Evidence from a Quasi‐Natural Experiment
Authors: Cappelletti Giuseppe , Guazzarotti Giovanni , Tommasino Pietro 
Published: May 2019

AbstractWe propose a new method to identify the impact of a change in the tax burden on mutual fund inflows. We use quasi‐experimental data from Italy where, starting from July 2011, the tax regime for domestic mutual funds was changed from an accruals basis to a realisation basis, while the taxation of foreign funds remained on a realisation basis. We find that the reform has had a positive effect on net inflows of Italian funds (the treated group) with respect to foreign funds (the control group). The effect is both economically and statistically significant. Moreover, there is no evidence that the increase in the demand for Italian funds came at the expense of foreign funds.