bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hearing recovery from deafness caused by bromate intoxication
Authors: Suzuki J , Takanashi Y , Koyama A , Katori Y 
Published: November 2018

AbstractObjectivesSodium bromate is a strong oxidant, and bromate intoxication can cause irreversible severe-to-profound sensorineural hearing loss. This paper reports the first case in the English literature of bromate-induced hearing loss with hearing recovery measured by formal audiological assessment.Case reportA 72-year-old woman was admitted to hospital with complaints of profound hearing loss, nausea, diarrhoea and anuria after bromate ingestion in a suicide attempt. On admission, pure tone audiometry and auditory brainstem responses showed profound bilateral deafness. Under the diagnosis of bromate-induced acute renal failure and sensorineural hearing loss, continuous haemodiafiltration was performed. When dialysis was discontinued, pure tone audiometry and auditory brainstem responses showed partial threshold recovery from profound deafness.ConclusionSevere-to-profound sensorineural hearing loss is a common symptom of bromate intoxication. Bromate-induced hearing loss may be partially treated, and early application of continuous haemodiafiltration might be useful as a treatment for this intractable condition.
The cross-sectional relationships between consumption of takeaway food, eating meals outside the home and diet quality in British adolescents
Authors: Taher Ayyoub K , Evans Nina , Evans Charlotte EL 
Published: November 2018

AbstractObjectiveThe present study aimed to evaluate the association of frequency of consuming takeaway meals and meals out with diet quality of UK adolescents.DesignThe Diet Quality Index for Adolescents (DQI-A) tool was used to assess diet quality, where adolescents’ food intake was based on 4d diary records obtained from the UK cross-sectional National Diet and Nutrition Survey (NDNS) rolling programme Years 1–6. Models included confounders.SettingThe DQI-A relies on three components, specifically diet quality, diversity and equilibrium, which reflect the degree of adherence of an adolescent’s diet with food-based dietary guidelines.ParticipantsBritish (n 2045) adolescents aged 11–18 years.ResultsMean diet quality score for all adolescents was 20·4 % (overall DQI-A score range: −33 to 100 %). After adjusting for age, gender and equivalised household income, DQI-A% score was higher for low and moderate takeaway consumers by 7·4 % (95 % CI 5·5, 9·2; P<0·01) and 3·5 % (95 % CI 1·9, 5·1; P<0·01), respectively, v. frequent consumers. Significant differences were also observed between low, moderate and frequent takeaway consumers among all DQI-A components and sub-components (P<0·05), except for the diet adequacy sub-component (DAx). Results for frequent consumption of meals out were similar but attenuated and not statistically significant for individual components before or after adjusting for confounders.ConclusionsFrequent consumption of takeaway meals may have a negative impact on adolescents’ diet quality and therefore policies to reduce the intake of takeaways should be considered in this age group.
The limits of authoritarian rule: policy making and deliberation in urban village regeneration in China
Authors: Niu Pu , Wagenaar Hendrik 
Published: November 2018

AbstractThe subject of this paper is the role of democratic deliberation as a policy instrument for district and local administrations in the urban village regeneration process. This paper contributes to a better understanding of the relationship between democratic deliberation and public policy making, and the theory of deliberative systems. Deliberation in the context of urban village regeneration is part of a complex, scalar, political-administrative system, with many actors whose activities are often not aligned. Although this configuration has authoritarian traits and operates largely without the protection of a strong and well-functioning rule of law, it is not all-sovereign. In fact, one of the most fascinating aspects of urban village deliberation is the way that reveals the limits of authoritarian rule in a modern national and international context. As we show, the Party encounters the same problems of technical, social, and institutional complexity, with the ensuing limits on vertical steering, as administrations in democratic countries. Using the case of Q village, we describe how hierarchical project management sits uneasily with village deliberation throughout the process. When officials attempt to curtail the legally mandated village deliberation process, they encounter stiff resistance and even a participation strike.
Perspectives on political party death: theorizing and testing Downsian and sociological rationales
Authors: Bolleyer Nicole , Ibenskas Raimondas , Bischoff Carina 
Published: November 2018

AbstractWhich of the new political parties that emerged in advanced democracies faded away and which ones managed to survive and why? Considering a party as dead once it ceases to nominate candidates in any elections, we develop two sets of hypotheses to account for party death derived from two conceptions of political parties. One conceptualizes parties as vehicles formed by career-oriented politicians eager to maximize individual rewards. Failure to deliver seats or government access is therefore expected to predict an earlier death. The other conceptualizes parties as societal organizations that serve representational functions valued in themselves by elites and members alike. This conception stresses the importance of roots in society or ideological novelty. Using survival analysis, we test our hypotheses in 17 advanced democracies based on a new data set covering 144 new parties from birth until their (potential) death. Arguments derived from both conceptions have significant support stressing the complexity of the drivers underpinning parties’ very existence.
The Melting Column as a Filter of Mantle Trace‐Element Heterogeneity
Authors: Bo Tong , Katz Richard F. , Shorttle Oliver , Rudge John F. 
Published: November 2018

AbstractThe observed variability of trace‐element concentration in basaltic lavas and melt inclusions carries information about heterogeneity in the mantle. The difficulty is to disentangle the contributions of source heterogeneity (i.e., spatial variability of mantle composition before melting) and process heterogeneity (i.e., spatial and temporal variability in melt transport). Here we investigate the end‐member hypothesis that variability arises due to source heterogeneity alone. We model the attenuation of trace‐element variability introduced into the bottom of a one‐dimensional, steady‐state melting column. Our results show that the melting column can be considered to be a filter that attenuates variability according to the wavelength of heterogeneity, the partition coefficient of the trace element, melt productivity, and the efficiency of melt segregation. We further show that while the model can be fit to the observations, this requires assumptions inconsistent with constraints on the timescales of magma assembly. Hence, we falsify the end‐member hypothesis and, instead, conclude that observed variability requires heterogeneity of melt transport. This might take the form of channels or waves and would almost certainly interact with source heterogeneity.
Late Cenozoic Erosion Estimates for the Northern Barents Sea: Quantifying Glacial Sediment Input to the Arctic Ocean
Authors: Lasabuda Amando , Geissler Wolfram H. , Laberg Jan Sverre , Knutsen Stig‐Morten , Rydningen Tom Arne , Berglar Kai 
Published: November 2018

AbstractA compilation of seismic data has been used to characterize the Neogene‐Quaternary sedimentary succession of the northwestern Barents Sea continental margin to better understand the paleoenvironmental evolution and the sedimentary processes involved. The Neogene strata are dominated by contourites related to the ocean circulation established from the opening of the Fram Strait connecting the Atlantic and the Arctic Oceans (< ~17.5 Ma). The upper Plio‐Pleistocene strata (< ~2.7 Ma) are dominated by stacked gravity‐driven deposits forming trough‐mouth fans that were sourced from paleo‐ice streams. Within the interfan areas, contouritic sedimentation prevailed. Thus, this margin provides an example of interaction of glacigenic debris flows, contour currents, and hemipelagic/glacimarine sedimentary processes. A total of ~29,000 km3 of sediments with an average sedimentation rate of about 0.24 m/Kyr were estimated. These numbers reflect the sediment input to this part of the Arctic Ocean from the northwestern Barents Sea shelf and adjacent land areas. For the first time, the average erosion and erosion rates for this source area are estimated using a mass balance approach. Approximately 410–650 m of erosion has on average occurred, corresponding to an average erosion rate of ~0.15–0.24 m/Kyr. These rates are comparable to those reported from other glaciated margins, including the western Svalbard and mid‐Norway margin, but up to only half the rates reported from the western Barents Sea margin. This variation is interpreted due to the size and bedrock types of the drainage area, ice dynamics, and the continental slope gradient.
Concentrations and Water Mass Transport of Legacy POPs in the Arctic Ocean
Authors: Ma Yuxin , Adelman Dave A. , Bauerfeind Eduard , Cabrerizo Ana , McDonough Carrie A. , Muir Derek , Soltwedel Thomas , Sun Caoxin , Wagner Charlotte C. , Sunderland Elsie M. , Lohmann Rainer 
Published: November 2018

AbstractThe Arctic Ocean is known to be contaminated by various persistent organic pollutants (POPs). The Fram Strait, the only deepwater passage to the Arctic Ocean (from the Atlantic Ocean), represents an unquantified gateway for POPs fluxes into and out of the Arctic. Polyethylene passive samplers were deployed in vertical profiles in the Fram Strait and in air and surface water in the Canadian Archipelago to determine the concentrations, profiles, and mass fluxes of dissolved polychlorinated biphenyls (PCBs) and organochlorine pesticides. In the Fram Strait, higher concentrations of ΣPCBs (1.3–3.6 pg/L) and dichlorodiphenyltrichloroethanes (ΣDDTs, 5.2–9.1 pg/L) were observed in the deepwater masses (below 1,000 m), similar to nutrient‐like vertical profiles. There was net southward transport of hexachlorobenzene and hexachlorocyclohexanes (ΣHCHs) of 0.70 and 14 Mg/year but a net northward transport of ΣPCBs at 0.16 Mg/year through the Fram Strait.
Unveiling Earth's Hidden Magnetization
Authors: Vervelidou Foteini , Lesur Vincent 
Published: November 2018

AbstractRock magnetization carries information about rocks' properties, Earth's tectonic history, and evolution of its core magnetic field. One way to study Earth's magnetization is through the magnetic signal it generates, known as the lithospheric magnetic field. Although there exist global lithospheric magnetic field models of high spatial resolution, this path has not yet been very fruitful because of an important limitation: only part of the magnetization is visible, that is, produces an observable magnetic field signal. We refer to the remaining part of the magnetization as the hidden magnetization, and we recover it from a lithospheric magnetic field model under a few reasonable assumptions. We find that Earth's hidden magnetization at high and middle latitudes is very similar, both in intensity and shape, to Earth's visible magnetization. At low latitudes, the estimated hidden magnetization relies on a priori information and can be very different from the visible one.
Marine Geophysical Investigation of the Chain Fracture Zone in the Equatorial Atlantic From the PI‐LAB Experiment
Authors: Harmon Nicholas , Rychert Catherine , Agius Matthew , Tharimena Saikiran , Le Bas Tim , Kendall J. Michael , Constable Steven 
Published: November 2018

AbstractThe Chain Fracture Zone is a 300‐km‐long transform fault that offsets the Mid‐Atlantic Ridge. We analyzed new multibeam bathymetry, backscatter, gravity, and magnetic data with 100% multibeam bathymetric data over the active transform valley and adjacent spreading segments as part of the Passive Imaging of the Lithosphere Asthenosphere Boundary (PI‐LAB) Experiment. Analyses of these data sets allow us to determine the history and mode of crustal formation and the tectonic evolution of the transform system and adjacent ridges over the past 20 Myr. We model the total field magnetic anomaly to determine the age of the crust along the northern ridge segment to better establish the timing of the variations in the seafloor fabric and the tectonic‐magmatic history of the region. Within the active transform fault zone, we observe four distinct positive flower structures with several en échelon fault scarps visible in the backscatter data. We find up to −10 mGal residual Mantle Bouguer Anomaly in the region of the largest positive flower structure within the transform zone suggesting crustal thickening relative to the crustal thinning typically observed in fracture zones in the Atlantic. The extensional/compressional features observed in the Chain Transform are less pronounced than those observed further north in the Vema, St. Paul, and Romanche and may be due to local ridge segment adjustments.
Oil Droplets Transport Under a Deep‐Water Plunging Breaker: Impact of Droplet Inertia
Authors: Cui Fangda , Boufadel Michel C. , Geng Xiaolong , Gao Feng , Zhao Lin , King Thomas , Lee Kenneth 
Published: November 2018

AbstractOil droplets transport in a deep‐water plunging breaker of height 0.18 m was simulated by coupling computational fluid dynamics with Lagrangian particle tracking. The Reynolds‐averaged Navier‐Stokes equations were solved in a two‐dimensional vertical slice within the computational fluid dynamics code Fluent to reproduce the movement of breaking waves in the absence of wind stress and large‐scale turbulence. The generated plunging breaker generated two additional (residual) breakers, consistent with experimental observations from the literature. The hydrodynamics of the breaker was subsequently used as input to the Lagrangian particle tracking code, NEMO3D, where the equation of motion was solved for each droplet by incorporating the major local forces including those due to the mass of the droplet. The droplet sizes were selected to vary from 100 to 600 μm. It was found that the droplet plume split into three clouds, one below and upstream of the first breaker, one below the second breaker, and one downstream of the third breaker. The largest penetration depth was within the second cloud. The largest entrainment (fraction of surface mass in the water column) occurred for the 100‐μm droplets, while the smallest entrainment occurred for the 600 μm. However, the 300 μm exhibited smaller entrainment than smaller droplets, which is due to the vortical nature of the breaker, which advected the 300 μm horizontally and then upward. This has implications on the biodegradation and dissolution of droplets of various sizes, and on the application of countermeasures such as dispersant.
Driving Factors of Aerosol Properties Over the Foothills of Central Himalayas Based on 8.5 Years Continuous Measurements
Authors: Hooda R. K. , Kivekäs N. , O'Connor E. J. , Collaud Coen M. , Pietikäinen J.‐P. , Vakkari V. , Backman J. , Henriksson S. V. , Asmi E. , Komppula M. , Korhonen H. , Hyvärinen A.‐P. , Lihavainen H. 
Published: November 2018

AbstractThis study presents analysis of in situ measurements conducted over the period 2005–2014 in the Indian Himalayas to give a thorough overview of the factors and causes that drive aerosol properties. Aerosol extensive properties (namely, particle number concentration, scattering coefficient, equivalent black carbon, PM2.5, and PM10) have 1.5–2 times higher values in the early to late afternoon than during the night, and a strong seasonality. The interannual variability is ±20% for both PM2.5 and total particle number concentration. Analysis of the data shows statistically significant decreasing trends of −2.3 μg m−3 year−1 and −2.7 μg m−3 year−1 for PM2.5 and PM10, respectively, over the study period. The mountainous terrain site (Mukteshwar, MUK) is primarily under the influence of air from the plains. This is due to convective transport processes that are enhanced by local and mesoscale topography, leading to pronounced valley/mountain winds and consequently to atmospheric boundary layer air lifting from the plains below. The transport from plains is evident in seasonal‐diurnal patterns observed at MUK. The timing of the patterns corresponds with changes in turbulence and water vapor (q). According to our analysis, using these as proxies is a viable method for examining boundary layer influence in the absence of direct atmospheric boundary layer height measurements. Comparing the measurements with climate models shows that even regional climate models have problems capturing the orographic influence accurately at MUK, highlighting the importance of long‐term direct measurements at multiple points to understand aerosol behavior in mountainous areas.
Sulforaphane metabolites reduce resistance to paclitaxel via microtubule disruption
Authors: Wang Yalin , Zhou Yan , Zheng Zhongnan , Li Juntao , Yan Yuting , Wu Wei 
Published: November 2018

AbstractLong treatment with paclitaxel (PTX) might increase resistance and side-effects causing a failure in cancer chemotherapy. Here we uncovered that either sulforaphane-cysteine (SFN-Cys) or sulforaphane-N-acetyl-cysteine (SFN-NAC) induced apoptosis via phosphorylated ERK1/2-mediated upregulation of 26 S proteasome and Hsp70, and downregulation of βIII-tubulin, XIAP, Tau, Stathmin1 and α-tubulin causing microtubule disruption in human PTX-resistant non-small cell lung cancer (NSCLC) cells. Knockdown of either βIII-tubulin or α-tubulin via siRNA increased cell sensitivity to PTX, indicating that these two proteins help cells increase the resistance. Tissue microarray analysis showed that overexpression of βIII-tubulin correlated to NSCLC malignant grading. Immunofluorescence staining also showed that SFN metabolites induced a nest-like microtubule protein distribution with aggregation and disruption. Co-immunoprecipitation showed that SFN metabolites reduced the interaction between βIII-tubulin and Tau, and that between α-tubulin and XIAP. The combination of PTX with SFN metabolites decreased the resistance to PTX, and doses of both PTX and SFN metabolites, and enhanced apoptosis resulting from activated Caspase-3-caused microtubule degradation. Importantly, the effective dose of SFN metabolites combined with 20 nM PTX will be low to 4 μM. Thus, we might combine SFN metabolites with PTX for preclinical trial. Normally, more than 20 μM SFN metabolites only leading to apoptosis for SFN metabolites hindered their applications. These findings will help us develop a low-resistance and high-efficiency chemotherapy via PTX/SFN metabolites combination.
MiR-27b regulates podocyte survival through targeting adenosine receptor 2B in podocytes from non-human primate
Authors: Zheng Zuokang , Hu Hong , Tong Yanrong , Hu Zhixia , Cao Shiyu , Shan Ce , Lin Wenhe , Yin Yike , Li Zhonghan 
Published: November 2018

AbstractMicroRNAs are a group of small non-coding RNAs that play key roles in almost every aspect of mammalian cell. In kidney, microRNAs are required for maintaining normal function of renal cells, disruption of which contributes to pathogenesis of renal diseases. In this study, we investigated the potential role of miRNAs as key regulators of podocyte survival by using a primary cell culture model from non-human primates (NHPs). Through microRNA profile comparison in glomeruli from mouse, rat and NHP, miR-27b was found to be among a list of glomeruli-enriched miRNA conserved across species. In NHP primary podocyte culture, significant downregulation of miR-27b was observed during treatment of puromycin aminonucleoside (PAN), a classic nephrotoxin. Overexpression of miR-27b enhanced PAN-induced apoptosis and cytoskeleton destruction in podocytes while its inhibition had a protective effect. Target identification analysis identified Adora2b as a potential direct target of miR-27b. Ectopic expression of miR-27b suppressed both Adora2b mRNA and protein expression, whereas inhibition of miR-27b increased the transcript and protein expression levels of Adora2B. Dual luciferase assay further confirmed Adora2b as a direct target of miR-27b. Furthermore, knockdown of Adora2b by siRNAs enhanced PAN-induced apoptosis, similar to the phenotypes we had observed with miR-27b overexpression. In addition, stimulating the adenosine signaling by an Adora2b agonist, NECA, improved podocyte survival upon PAN treatment. Taken together, our data identified a novel role of miR-27b-adora2b axis in primary podocyte survival upon injury and suggested a critical role of adenosine signaling pathway in podocyte protection.
A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release
Authors: Xu Yiyang , Yang Zhiyuan , Horan Lucas H. , Zhang Pengbo , Liu Lianxing , Zimdahl Bryan , Green Shon , Lu Jingwei , Morales Javier F. , Barrett David M. , Grupp Stephan A. , Chan Vivien W. , Liu Hong , Liu Cheng 
Published: November 2018

AbstractThe clinical use of genetically modified T-cell therapies has led to unprecedented response rates in leukemia and lymphoma patients treated with anti-CD19 chimeric antigen receptor (CAR)-T. Despite this clinical success, FDA-approved T-cell therapies are currently limited to B-cell malignancies, and challenges remain with managing cytokine-related toxicities. We have designed a novel antibody-T-cell receptor (AbTCR) platform where we combined the Fab domain of an antibody with the γ and δ chains of the TCR as the effector domain. We demonstrate the ability of anti-CD19-AbTCR-T cells to trigger antigen-specific cytokine production, degranulation, and killing of CD19-positive cancer cells in vitro and in xenograft mouse models. By using the same anti-CD19 binding moiety on an AbTCR compared to a CAR platform, we demonstrate that AbTCR activates cytotoxic T-cell responses with a similar dose-response as CD28/CD3ζ CAR, yet does so with less cytokine release and results in T cells with a less exhausted phenotype. Moreover, in comparative studies with the clinically validated CD137 (4-1BB)-based CAR, CTL019, our anti-CD19-AbTCR shows less cytokine release and comparable tumor inhibition in a patient-derived xenograft leukemia model.
Repurposing CRISPR-Cas12b for mammalian genome engineering
Authors: Teng Fei , Cui Tongtong , Feng Guihai , Guo Lu , Xu Kai , Gao Qingqin , Li Tianda , Li Jing , Zhou Qi , Li Wei 
Published: November 2018

AbstractThe prokaryotic CRISPR-Cas adaptive immune systems provide valuable resources to develop genome editing tools, such as CRISPR-Cas9 and CRISPR-Cas12a/Cpf1. Recently, CRISPR-Cas12b/C2c1, a distinct type V-B system, has been characterized as a dual-RNA-guided DNA endonuclease system. Though being active in vitro, its cleavage activity at endogenous genome remains to be explored. Furthermore, the optimal cleavage temperature of the reported Cas12b orthologs is higher than 40 °C, which is unsuitable for mammalian applications. Here, we report the identification of a Cas12b system from the Alicyclobacillus acidiphilus (AaCas12b), which maintains optimal nuclease activity over a wide temperature range (31 °C–59 °C). AaCas12b can be repurposed to engineer mammalian genomes for versatile applications, including single and multiplex genome editing, gene activation, and generation of gene mutant mouse models. Moreover, whole-genome sequencing reveals high specificity and minimal off-target effects of AaCas12b-meditated genome editing. Our findings establish CRISPR-Cas12b as a versatile tool for mammalian genome engineering.