bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gentiopicroside-Induced gastric cancer necroptosis via the HIF-1 signaling pathway: A study involving molecular docking and experimental validation
Authors: Xiong Bo , Fan Mingjie , Wang Zhihui , Yang Xiaolu , Cao Shan , Shen Jie , Fan Beibei 
Published: November 2024

Objectives
Gentiopicroside is an effective treatment for several types of cancer, inducing numerous forms of programmed cancer cell death. However, there are few investigations into the role of necroptosis. By utilizing molecular docking, and experimental validation, this study aims to investigate whether gentiopicroside elicits necroptosis in gastric cancer.

Methods
Using software PyMOL and AutoDock, gentiopicroside was docked with RIPK1, RIPK3, MLKL and HIF-1α proteins. And a cell study was performed based on SGC7901 cells. The necroptosis-related proteins and HIF-1 signaling pathways were explored using western blot (WB) analysis. Finally, an animal study was performed to test the inhibitory effect in vivo.

Results
Docking studies indicated that the docking energies of gentiopicroside to necroptosis-related proteins and necroptosis-characteristic proteins are all below -5 kcal/mol. Additionally, gentiopicroside cells reduce gastric cancer viability and inhibit proliferation. Results from the animal experiments indicated that gentiopicroside inhibits the growth of the gastric cancer xenograft tumor. Western blot and immunohistochemistry (IHC) staining demonstrated that gentiopicroside higher p-receptor-interacting protein kinase 3(p-RIPK3) levels in vitro and in vivo.

Conclusion
The findings of this study revealed that necroptosis is involved in the inhibitory effect of gentiopicroside toward gastric cancer.
An ADaptivE PrenaTal (ADEPT) intervention to increase childhood vaccinations: Protocol for a cluster randomized trial and nested mixed methods evaluation
Authors: Vasudevan Lavanya , Porter Rachael M. , Campos Ilse , Turner Elizabeth L. , Stinnett Sandra S. , Zullig Leah L. , Walter Emmanuel B. , Swamy Geeta K. , Bednarczyk Robert A , Orenstein Walter A. , Gray Beverly 
Published: November 2024

Background
There is limited evidence to assess if interventions implemented during pregnancy proactively mitigate parental vaccine hesitancy and promote timely vaccination among children after birth. This study protocol describes the evaluation of an ADaptivE PrenaTal (ADEPT) intervention to increase childhood vaccinations that is implemented with first-time pregnant individuals (PIs).

Methods
Within the framework of a type 1 effectiveness-implementation hybrid study design, a cluster-randomized trial (CRT) will determine the effectiveness of ADEPT at increasing childhood vaccinations, and a nested explanatory mixed methods (NMM) study will assess changes in parental vaccine hesitancy. Study practices will be randomized to deliver ADEPT in addition to standard of care or standard of care alone. Providers at intervention sites will participate in a 4-part training program on childhood vaccines and effective communication. During a routine prenatal visit, providers will discuss vaccines recommended for the PI during pregnancy and for the child after birth, following which PIs will be screened for vaccination intention. Vaccine-hesitant PIs will be offered adaptive components of the intervention, which include an educational website and phone call with a vaccine navigator to discuss concerns. They will also be offered enrollment into the NMM study, where their vaccination intention will be assessed post-intervention. After PIs give birth, their child’s vaccination outcomes at 2 months will be extracted from the state immunization registry. The primary study outcome is the difference in timely childhood vaccination at 2 months between the intervention and control arms. The secondary outcome is reduction in vaccine hesitancy assessed among PIs in the NMM study as the pre-post intervention change in vaccination intention.

Discussion
The study findings are expected to contribute evidence on the effectiveness of prenatal interventions to proactively mitigate parental vaccine hesitancy and promote timely vaccinations after the child’s birth.

Trial registration
The study protocol is registered in ClinicalTrials.gov (NCT05795855).
The trajectory of anxiety and depressive symptoms and the impact of self-injury: A longitudinal 12-month cohort study of individuals with psychiatric symptoms
Authors: Ojala Olivia , Garke Maria Å. , El Alaoui Samir , Forsström David , Hedman-Lagerlöf Maria , Jangard Simon , Lundin Johan , Rozental Alexander , Shahnavaz Shervin , Sörman Karolina , Lundgren Tobias , Hellner Clara , Jayaram-Lindström Nitya , Månsson Kristoffer N. T. 
Published: November 2024

Background
Individuals reporting self-injury are at greater risk of several adverse outcomes, including suicide. There is reason to be concerned how these individuals cope when stressful life events increase. This study aimed to investigate the trajectories of anxiety and depressive symptoms and the predictive value of self-injury history in individuals with psychiatric symptoms during the unique and stressful conditions of the COVID-19 pandemic.

Methods
In a longitudinal population cohort study (N = 1810) ranging from 2020 to 2022, anxiety (measured by Generalized Anxiety Disorder, GAD-7) and depressive symptoms (measured by Patient Health Questionnaire, PHQ-9) were self-reported monthly during 12 months. Latent growth curve models with and without self-reported self-injury history as predictors were conducted.

Results
Overall, anxiety and depressive symptoms decreased from baseline, but remained at moderate severity at follow-up. Individuals reporting suicidal or nonsuicidal self-injury reported significantly higher symptom severity at baseline. In addition, individuals reporting suicidal self-injury demonstrated a slower rate of decline in the symptom load over the course of 12 months.

Conclusions
Over the course of 12 months, anxiety and depressive symptoms decreased in individuals with psychiatric symptoms, but still indicate a psychiatric burden. Individuals with a history of self-injury could be more vulnerable in face of stressful conditions such as those experienced during the COVID-19 pandemic.
Effects of the eccentric chin closure exercise on submental muscle activation, muscle strength, dysphagia limit, perceived exertion and pain in healthy volunteers: A prospective, randomized parallel group study
Authors: Cengiz Emre , Serel Arslan Selen , Yaşaroğlu Ömer Faruk , Alıcı Rabia , Demir Numan , Topçuoğlu Mehmet Akif , Mutlu Akmer 
Published: November 2024

Objective(s)
Eccentric Chin Closure (ECC) exercise is a model designed to strengthen the suprahyoid muscles, aligned with the principles of eccentric exercise and the characteristics of these muscles. This study aimed to investigate the effects of the ECC exercise on submental muscle activation, muscle strength, dysphagia limit, perceived exertion, and pain, in comparison to the Shaker and Chin-Tuck Against Resistance (CTAR) exercises.

Methods
In this parallel randomized controlled trial, for the initial assessment fifty-four healthy volunteers aged between 19–28 years with submental activations were recorded during the isotonic components of the Shaker, CTAR, and ECC exercises using surface electromyography. After the initial assessment, the volunteers were randomized to the Shaker, CTAR, and ECC exercise groups with 18 volunteers each group, and followed an 8-week exercise program. Maximum voluntary isometric contractions (MVC), muscle strength, dysphagia limit, perceived exertion, and pain were recorded at baseline in 4th week and 8th week.

Results
At the initial assessment, lower submental muscle activation was observed during the Shaker exercise (p<0.05). Follow-up measurements demonstrated that the eight weeks of exercise was effective in increasing MVC activations and muscle strength across all groups. Considering the group*time effect, CTAR (0.36 ± 0.10) and ECC (0.40 ± 0.14) exercises were found to be more effective in increasing MVC than the Shaker (0.29 ± 0.19) exercise (F = 7.203, p<0.001), and the ECC (32.87 ± 6.55) exercise was more effective in improving muscle strength than both the Shaker (26.03 ± 5.86) and CTAR (27.95 ± 6.33) exercises (F = 6.786, p<0.001). Perceived exertion (F = 1.044, p = 0.388) and pain scores (F = 0.346, p = 0.846) showed statistically similar changes across the Shaker, CTAR, and ECC exercise groups.

Conclusion
The ECC exercise demonstrated similar effects on MVC to CTAR, but resulted in greater MVC than the Shaker exercise among healthy volunteers at 8 weeks. ECC was also more effective compared to Shaker and CTAR in terms of strength gain, with all exercises showing comparable levels of perceived exertion and pain.
Analysis of survival-related factors in patients with endometrial cancer using a Bayesian network model
Authors: Zhang Huan , Zhao Shan , Lv Pengzhong 
Published: November 2024

Background
In recent years, remarkable progress has been made in the use of machine learning, especially in analyzing prognosis survival data. Traditional prediction models cannot identify interrelationships between factors, and the predictive accuracy is lower. This study aimed to construct Bayesian network models using the tree augmented naïve algorithm in comparison with the Cox proportional hazards model.

Methods
A Bayesian network model and a Cox proportional hazards model were constructed to analyze the prognostic factors of endometrial cancer. In total, 618 original cases obtained from the Surveillance, Epidemiology, and End Results database were used to construct the Bayesian network model, which was compared with the traditional Cox proportional hazards model by analyzing prognostic factors. External validation was performed using a dataset from The First Affiliated Hospital of Shandong First Medical University.

Results
The predictive accuracy, area under the receiver operating characteristic curve, and concordance index for the Bayesian network model were 74.68%, 0.787, and 0.72, respectively, compared to 68.83%, 0.723, and 0.71, respectively, for the Cox proportional hazards model. Tumor size was the most important factor for predicting survival, followed by lymph node metastasis, distant metastasis, chemotherapy, lymph node resection, tumor stage, depth of invasion, tumor grade, histological type, age, primary tumor site, radiotherapy and surgical sequence, and radiotherapy.

Conclusion
The findings indicate that the Bayesian network model is preferable to the Cox proportional hazards model for predicting survival in patients with endometrial cancer.
The effectiveness of a structured validated questionnaire to assess student perception with virtual pharmacy simulation in pharmacy practice experiential education
Authors: Amirthalingam Palanisamy , Pakkir Mohamed Shahul Hameed , Veeramani Vinoth Prabhu , Nagoor Thangam Mathar Mohideen , Alanazi Majed Falah , Dhanasekaran Muralikrishnan , Mani Vasudevan , Ali Mostafa A. Sayed 
Published: November 2024

Background and objective
MyDispense is one of the virtual simulations that has already been established as a suitable alternative for live experiential education in the pharmacy curriculum. However, there are no structured validated questionnaires available to assess the students’ perception while integrating MyDispense with pharmacy practice experiential education. Therefore, the present study aimed to validate a structured questionnaire and use the questionnaire to assess the student perception of various pharmacy practice experiential education.

Methods
Content and construct validity procedure was used to validate the questionnaire. Two hundred students consented to participate in validating the questionnaire. The validated questionnaire assessed the students’ perception of integrating MyDispense with Introductory Pharmacy Practice Experience 2 (IPPE2) and Advanced Pharmacy Practice Experience (APPE) courses. The questionnaire was structured with four domains which were: exercise, instructor, technical, and communication. Each domain carried five items; therefore, the whole questionnaire had 20 items that succeeded in content validity. In the survey, 121 fourth-year and 117 fifth-year Pharm.D. students volunteered to convey their perception of integrating MyDispense with IPPE 2 and APPE, respectively. The survey was conducted before and after the MyDispense exam in both the courses.

Results
The Cronbach’s α and McDonald’s ω coefficients were > 0.8 in all four domains, indicating that the items related to the four domains have good internal consistency. In Exploratory Factor Analysis (EFA), two items were found to cross-load in the exercise domain and removed. Therefore, the EFA proposes 18 items for the confirmatory factor analysis (CFA). In CFA, five fit indices were found to be satisfactory, and this indicates construct was good enough to assess the student perception. In IPPE 2, the pre-test response, the students had significantly higher satisfaction (p < 0.05) with all five items related to the technical domain. In APPE, the students had a significantly (p < 0.05) higher perception of all the items related to the exercise and technical domain in the pre-test compared to the post-test. Therefore, the student’s pre-test feedback allowed the instructor to identify and make the necessary corrections in the exercises to improve the quality exercises.

Conclusion
This study provides a validated 18-item questionnaire to assess the student perception of integrating MyDispense in experiential education. The integration of MyDispense in experiential education needs to be done carefully by assessing student perception.
Analyzing the effect of sleep duration, chronotype, and social jet lag on anxiety disorders and health-related quality of life: A cross-sectional study
Authors: Jung Sung Min , Lee Mee-Ri 
Published: November 2024

Background
Anxiety disorders significantly impair the quality of life (QOL). Studies on the effect of sleep duration, chronotype, and social jet lag on anxiety disorders are limited. This study aimed to elucidate the contributions of sleep duration, chronotype, and social jet lag to the prevalence and severity of anxiety disorders in Koreans.

Methods
This study used data of 9,874 Korean adults from the Korea National Health and Nutrition Examination Survey 2021–2022. Anxiety was assessed using the Generalized Anxiety Disorder-7 scale, and health-related QOL was measured using the Health-Related Quality of Life Instrument with 8-Items. Complex sample logistic regression models were used to evaluate the associations between sleep duration, chronotype, and social jet lag and anxiety disorders, with analyses stratified by sex.

Results
Sleep duration of <6 h, evening chronotype, and social jet lag of >2 h were significantly associated with a high prevalence of anxiety disorders in women; however, in men, only sleep duration of <6 h was associated with anxiety disorders. Sleep duration of <6 h and evening chronotype were associated with low QOL in women but not in men.

Conclusion
This study highlights the importance of adequate sleep and circadian alignment for mental health, particularly in women. Public health initiatives should focus on promoting healthy sleep habits to improve mental health and QOL. Further research is required to understand the causal pathways and sex-specific mechanisms underlying these associations.
Laura Aguilar and Gil Cuadros: Legacies of 1990s Los Angeles Chicanx Resistance through Illness and Queer Friendship
Authors: Alvarez Pablo 
Published: November 2024

Abstract
This article explores the photography of Laura Aguilar through a research methodology that centers friendship and caretaking, a method that accentuates the centrality of queer community and love in her work and that makes visible a Chicanx AIDS consciousness, an awareness of the intersectional effects of AIDS within everyday Chicanx life and history. This research not only considers Aguilar's already-recognized work but also her physical home, her life story, her personal relationships, and her unpublished/unexhibited work, which reveal the multiple ways that AIDS appears throughout her artistic oeuvre and her life. Central to my analysis of Aguilar's photographic production is her long-standing friendship with writer Gil Cuadros, a tumultuous yet highly generative partnership for both artists. Their friendship reveals the need to look beyond the more obvious political imagery and organizational history of AIDS and to investigate the intimate and complex familial and community networks of that period. Understanding the importance of Aguilar and Cuadros's friendship to each other's work allows for a greater understanding of the way that art and activism inform one another through personal and queer familial bonds.
“It Ain't Easy Being Green”: Race and Time in Stormé DeLarverie's Butch Swagger and Presence
Authors: Jaime Karen 
Published: November 2024

Abstract
In this article, the author analyzes the cultural, racial, sexual, and gendered politics that inform the staged and quotidian performances of masculinity by the late Stormé DeLarverie. A mixed-race butch lesbian male impersonator who, in the 1950s and 1960s, performed with the famed Jewel Box Revue, a racially integrated drag show at the Apollo Theater, DeLarverie was also a central figure in the 1969 Stonewall Riots. The author reaches across DeLarverie's personal history, life-long activism, and staged performances as a way to frame the relationship between DeLarverie's gender presentation on stage and off, and her cabaret-style singing within a 1990s butch aesthetic. The author argues that DeLarverie's butch swagger and presence highlight a female masculinity readily legible in the 1990s, a female masculinity that troubles contemporary queer discourses surrounding “butch” as a marker for those assigned female at birth that now operates as out of place and time, under the threat of constant erasure, and framed within the vocabulary of extinction. The author challenges narratives forecasting the inevitable butch disappearance and, instead, proposes that DeLarverie's transtemporal embodiment and performance of a racialized female masculinity helps us to imagine future possibilities for butch survival.
3D simulation of double-needle bar warp-knitted clustered pile fabrics on DFS
Authors: Guan Songsong , Jiang Gaoming , Li Bingxian 
Published: November 2024

Abstract
The shortcomings of traditional pile fabric design and simulation in simulating clustered structures are addressed in this study by proposing a new three-dimensional (3D) simulation method. To accurately capture the details of clustered pile fabrics, a fine geometric model of a single pile loop is first established, and a novel geometric transformation algorithm, combined with rotational transformations and trigonometric calculations, is employed to achieve the natural aggregation of pile fibers, resulting in a highly realistic clustered structure. Additionally, to enhance design flexibility and accuracy, a pile design pattern is introduced, and for the first time, a Depth-First Search (DFS) algorithm is utilized for precise pattern recognition and determination of the directions of pile fibers, effectively solving the challenges of clustered area identification. To enhance the visual realism of the simulation, the Phong illumination model is adopted to simulate the lighting effects on the fabric surface, and blurring processes are applied to eliminate sharp edges and noise, resulting in a softer and more natural simulation output. Based on the recognition results from the DFS algorithm, the directions of the pile fibers are finely adjusted to achieve a realistic simulation of clustered pile fabrics. Experimental validation demonstrates that the proposed method produces 3D simulation results that closely resemble actual pile fabrics, demonstrating significant practical value and innovation.
Hydrogel promotes bone regeneration through various mechanisms: a review
Authors: Zheng Yuanyuan , Ke Zengguang , Hu Guofeng , Tong Songlin 
Published: November 2024

Abstract
Large defects in bone tissue due to trauma, tumors, or developmental abnormalities usually require surgical treatment for repair. Numerous studies have shown that current bone repair and regeneration treatments have certain complications and limitations. With the in-depth understanding of bone regeneration mechanisms and biological tissue materials, a variety of materials with desirable physicochemical properties and biological functions have emerged in the field of bone regeneration in recent years. Among them, hydrogels have been widely used in bone regeneration research due to their biocompatibility, unique swelling properties, and ease of fabrication. In this paper, the development and classification of hydrogels were introduced, and the mechanism of hydrogels in promoting bone regeneration was described in detail, including the promotion of bone marrow mesenchymal stem cell differentiation, the promotion of angiogenesis, the enhancement of the activity of bone morphogenetic proteins, and the regulation of the microenvironment of bone regeneration tissues. In addition, the future research direction of hydrogel in bone tissue engineering was discussed.
Big Data Misuse and European Contract Law
Authors: Börklüce Cihat 
Published: November 2024

Abstract
The dynamics of contractual interactions have been evolving in recent years, as big data introduces new dimensions to previously conventional contracts. This development intensifies the information asymmetry between the dominant and vulnerable parties, posing increasing challenges for consumers and the entirety of European contract law. This paper offers three main contributions to this discourse. First, the utilization of big data introduces a novel form of information asymmetry between contracting parties, further empowering the already dominant party while exacerbating the vulnerability of the weaker party. Second, contemporary European case law and legal scholarship advocate for a harmonious approach in which European regulations and national remedies complement one another in protecting individuals. Lastly, there are already instances indicating the misuse of big data, where multiple individual claims may arise at both European and national levels.
Relative captures and detection of male Ceratitis capitata using a natural oil lure or trimedlure plugs
Authors: Kharrat Saida , Gonzalez Francisco , Rodriguez Carlos , Calvo Carolina , Oehlschlager Cam 
Published: November 2024

Abstract
Traps baited with a lure emitting a natural oil enriched in α-copaene captured more male Ceratitis capitata Wiedemann (Diptera: Tephritidae) than traps baited with a 2 g plug of trimedlure during year-long trials in Tunisian citrus (Citrus sinensis Osbeck, Rutaceae) and Costa Rican coffee (Coffea arabica Linnaeus, Rubiaceae). In Costa Rica, traps were plastic McPhail traps while in Tunisia Tephriti traps were used. Trimedlure plugs were changed every six weeks while the natural oil lures were renewed every 12 weeks. During high population season, traps in all locations baited with the natural oil outperformed traps baited with 2 g plugs of trimedlure by 2–3 times. During the low season, a significantly higher percentage of traps baited with the natural oil caught at least one male medfly in comparison to traps baited with 2 g plugs of trimedlure in Tunisia, but statistical differences were not observed in Costa Rica. A longevity trial in Tunisia showed that traps baited with 16–18 weeks aged natural oil lures still captured statistically more male C. capitata than traps baited with 2 g plugs of trimedlure renewed every six weeks. These results show that traps baited with α-copaene lures are more sensitive than traps baited with the widely used 2 g trimedlure plugs.