bluuebunny/crossref_metadata_2025_split huggingface dataset:
WASP-180Ab: Doppler tomography of a hot Jupiter orbiting the primary star in a visual binary
Authors: Temple L Y , Hellier C , Anderson D R , Barkaoui K , Bouchy F , Brown D J A , Burdanov A , Collier Cameron A , Delrez L , Ducrot E , Evans D , Gillon M , Jehin E , Lendl M , Maxted P F L , McCormac J , Murray C , Nielsen L D , Pepe F , Pollacco D , Queloz D , Ségransan D , Smalley B , Thompson S , Triaud A H M J , Turner O D , Udry S , West R G , Zouhair B 
Published: September 2019

ABSTRACT
We report the discovery and characterization of WASP-180Ab, a hot Jupiter confirmed by the detection of its Doppler shadow and by measuring its mass using radial velocities. We find the 0.9  ±  0.1 MJup, 1.24  ±  0.04 RJup planet to be in a misaligned, retrograde orbit around an F7 star with Teff  =  6500 K and a moderate rotation speed of vsin i⋆  =  19.9 km s−1. The host star is the primary of a V  =  10.7 binary, where a secondary separated by ∼5 arcsec (∼1200 au) contributes ∼ 30 per cent of the light. WASP-180Ab therefore adds to a small sample of transiting hot Jupiters known in binary systems. A 4.6-d modulation seen in the WASP data is likely to be the rotational modulation of the companion star, WASP-180B.
Alliance of Genome Resources Portal: unified model organism research platform
Authors:   The Alliance of Genome Resources Consortium, Agapite Julie , Albou Laurent-Philippe , Aleksander Suzi , Argasinska Joanna , Arnaboldi Valerio , Attrill Helen , Bello Susan M , Blake Judith A , Blodgett Olin , Bradford Yvonne M , Bult Carol J , Cain Scott , Calvi Brian R , Carbon Seth , Chan Juancarlos , Chen Wen J , Cherry J Michael , Cho Jaehyoung , Christie Karen R , Crosby Madeline A , Pons Jeff De , Dolan Mary E , Santos Gilberto dos , Dunn Barbara , Dunn Nathan , Eagle Anne , Ebert Dustin , Engel Stacia R , Fashena David , Frazer Ken , Gao Sibyl , Gondwe Felix , Goodman Josh , Gramates L Sian , Grove Christian A , Harris Todd , Harrison Marie-Claire , Howe Douglas G , Howe Kevin L , Jha Sagar , Kadin James A , Kaufman Thomas C , Kalita Patrick , Karra Kalpana , Kishore Ranjana , Laulederkind Stan , Lee Raymond , MacPherson Kevin A , Marygold Steven J , Matthews Beverley , Millburn Gillian , Miyasato Stuart , Moxon Sierra , Mueller Hans-Michael , Mungall Christopher , Muruganujan Anushya , Mushayahama Tremayne , Nash Robert S , Ng Patrick , Paulini Michael , Perrimon Norbert , Pich Christian , Raciti Daniela , Richardson Joel E , Russell Matthew , Gelbart Susan Russo , Ruzicka Leyla , Schaper Kevin , Shimoyama Mary , Simison Matt , Smith Cynthia , Shaw David R , Shrivatsav Ajay , Skrzypek Marek , Smith Jennifer R , Sternberg Paul W , Tabone Christopher J , Thomas Paul D , Thota Jyothi , Toro Sabrina , Tomczuk Monika , Tutaj Marek , Tutaj Monika , Urbano Jose-Maria , Auken Kimberly Van , Slyke Ceri E Van , Wang Shur-Jen , Weng Shuai , Westerfield Monte , Williams Gary , Wong Edith D , Wright Adam , Yook Karen 
Published: September 2019

Abstract
The Alliance of Genome Resources (Alliance) is a consortium of the major model organism databases and the Gene Ontology that is guided by the vision of facilitating exploration of related genes in human and well-studied model organisms by providing a highly integrated and comprehensive platform that enables researchers to leverage the extensive body of genetic and genomic studies in these organisms. Initiated in 2016, the Alliance is building a central portal (www.alliancegenome.org) for access to data for the primary model organisms along with gene ontology data and human data. All data types represented in the Alliance portal (e.g. genomic data and phenotype descriptions) have common data models and workflows for curation. All data are open and freely available via a variety of mechanisms. Long-term plans for the Alliance project include a focus on coverage of additional model organisms including those without dedicated curation communities, and the inclusion of new data types with a particular focus on providing data and tools for the non-model-organism researcher that support enhanced discovery about human health and disease. Here we review current progress and present immediate plans for this new bioinformatics resource.
The effect of brain metastasis location on clinical outcomes: A review of the literature
Authors: Kancharla Pragnan , Ivanov Alexander , Chan Susie , Ashamalla Hani , Huang Raymond Y , Yanagihara Ted K 
Published: September 2019

Abstract
It is common clinical practice to consider the location of a brain metastasis when making decisions regarding local therapies and, in some scenarios, estimating clinical outcomes, such as local disease control and patient survival. However, the location of a brain metastasis is not included in any validated prognostic nomogram and it is unclear if this is due to a lack of a relationship or a lack of support from published data. We performed a comprehensive review of the literature focusing on studies that have investigated a relationship between brain metastasis location and clinical outcomes, including patient survival. The vast majority of reports anatomically categorized brain metastases as supratentorial or infratentorial whereas some reports also considered other subdivisions of the brain, including different lobes or with particular areas defined as eloquent cortex. Results were variable across studies, with some finding a relationship between metastasis location and survival, but the majority finding either no relationship or a weak correlation that was not significant in the context of multivariable analysis. Here, we highlight the key findings and limitations of many studies, including how neurosurgical resection might influence the relative importance of metastasis location and in what ways future analyses may improve anatomical categorization and resection status.
The Put It Out Project (POP) Facebook Intervention for Young Sexual and Gender Minority Smokers: Outcomes of a Pilot, Randomized, Controlled Trial
Authors: Vogel Erin A , Ramo Danielle E , Meacham Meredith C , Prochaska Judith J , Delucchi Kevin L , Humfleet Gary L 
Published: September 2019

Abstract

Introduction
This trial investigated whether a Facebook smoking cessation intervention culturally tailored to young sexual and gender minority (SGM) smokers (versus non-tailored) would increase smoking abstinence.

Methods
Participants were 165 SGM young adult US smokers (age 18–25) recruited from Facebook in April 2018 and randomized to an SGM-tailored (POP; N = 84) or non-tailored (TSP-SGM; N = 81) intervention. Interventions delivered weekly live counseling sessions and 90 daily Facebook posts to participants in Facebook groups. Primary analyses compared POP and TSP-SGM on biochemically verified smoking abstinence (yes/no; primary outcome), self-reported 7-day point prevalence abstinence (yes/no), reduction in cigarettes per week by 50+% from baseline (yes/no), making a quit attempt during treatment (yes/no), and stage of change (precontemplation/contemplation vs. preparation/action). Supplemental analyses compared POP to two historical control groups.

Results
POP participants were more likely than TSP-SGM participants to report smoking abstinence at 3 (23.8% vs. 12.3%; OR = 2.50; p = .03) and 6 months (34.5% vs. 12.3%; OR = 4.06; p &lt; .001) and reduction in smoking at 3 months (52.4% vs. 39.5%; OR = 2.11; p = .03). Biochemically verified smoking abstinence did not significantly differ between POP and TSP-SGM at 3 (OR = 2.00; p = .33) or 6 months (OR = 3.12; p = .08), potentially due to challenges with remote biochemical verification. In supplemental analyses, POP participants were more likely to report abstinence at 3 (OR = 6.82, p = .01) and 6 (OR = 2.75, p = .03) months and reduced smoking at 3 months (OR = 2.72, p = .01) than participants who received a referral to Smokefree.gov.

Conclusions
This pilot study provides preliminary support for the effectiveness of a Facebook smoking cessation intervention tailored to SGM young adults.

Implications
SGM individuals have disproportionately high smoking prevalence. It is unclear whether smoking cessation interventions culturally tailored to the SGM community are more effective than non-tailored interventions. This pilot trial found preliminary evidence that an SGM-tailored Facebook smoking cessation intervention increased reported abstinence from smoking, compared to a non-tailored intervention.

Trial Registration
NCT03259360.
Integrated mRNA, MicroRNA Transcriptome and Degradome Analyses Provide Insights into Stamen Development in Moso Bamboo
Authors: Cheng Zhanchao , Hou Dan , Ge Wei , Li Xiangyu , Xie Lihua , Zheng Huifang , Cai Miaomiao , Liu Jun , Gao Jian 
Published: September 2019

Abstract
A flower is an essential organ for sexual reproduction in flowering plants, which has been extensively studied in model plants. In this study, we used transcriptomic, small RNA and degradome analyses to characterize key microRNAs (miRNAs) and their targets in floral organs of moso bamboo. In total, we identified 13,051 differentially expressed genes and 109 known miRNAs from 26 miRNA families. We aligned the miRNAs to known miRNA databases and revealed some conserved as well as novel miRNAs. Sixteen conserved miRNAs were specifically and highly expressed in stamens, including miRNA159 and miRNA166. In situ hybridization shows that miRNA159 plays a key role in the regulation of stamen development, and the expression levels of its targets PheMYB98 and PheMYB42 were low. Furthermore, Phe-MIRNA159 partially recovers phenotypes of mir159ab double mutant. Overexpression of Phe-MIR159 could cause failure in anther dehisce, and the mature pollens could not be dispersed and further reduce fertility in Arabidopsis. Semi-thin section result shows that anther endothelial layer of Phe-MIRNA159 overexpressing lines is lack of secondary thickening, resulting in limited force for anther opening. Phe-miR159 may regulate the expression of genes related to secondary thickening through negative regulation of AtMYB33, affecting the anther dehiscence. Taken together, this study provides insights regarding molecular networks underlying floral organs development of moso bamboo.
Hand washing behavior change effect of community-based hygiene and sanitation intervention in low resource setting
Authors: Qazi Umair , Anwar Saeed 
Published: September 2019

Abstract

Background
Lack of hygiene and sanitation causes significant disease, disability and death. Majority of diarrheal diseases are related to hygiene and drinking water. Hand washing with soap after toilet use and before eating reduces these risks significantly.

Methods
This report is based on a behavior change project in the rural community setting (union council Nahqi), Peshawar, Pakistan aimed to improve hygiene- and sanitation-related behavior. A pre-intervention survey was conducted at household level (n = 958), followed by a structured behavior change communication program with motivational and educational material and key health messages for three months. Lastly, an end-line survey was conducted measuring change in practice domains.

Results
All the domains of hygiene and sanitation showed statistically significant improvement (11–59% P &lt; 0.001), including handwashing before meals (28.2%), before cooking (54.1%), before child feeding (21.2%), after defecation (30.6%); tooth brushing twice daily (7.3%); nail clipping at least weekly (16.3%); bathing daily (11.3%); change of clothing twice weekly (24.7%); covering the water containers (59.3%) and house orderliness (30.6%).

Conclusion
The findings conclude that a behavior change communication program that is in accord with community needs, level of their understanding, beliefs and sociocultural norms is well received for positive behavior change.
Pathology of immune-mediated tissue lesions following treatment with immune checkpoint inhibitors
Authors: Ibraheim Hajir , Perucha Esperanza , Powell Nick 
Published: September 2019

Abstract
Immune check point inhibitor (CPI) therapy has revolutionized treatment paradigms for several cancers, but at the cost of triggering a diverse spectrum of immune-mediated injury to non-cancer tissues. The complex biology of these toxicities remains incompletely understood, partly because tissue acquisition from affected areas can be challenging to retrieve, thus hindering development of targeted therapy. Here, we review the literature describing pathology of immune-mediated tissue lesions including gastrointestinal, skin, rheumatic, pulmonary, cardiac, renal and hepatic lesions and highlight key immunological insights.
Young Adult Caregiver Strain and Benefits
Authors: King McLaughlin Jessica , Greenfield Jennifer C , Hasche Leslie , De Fries Carson 
Published: September 2019

Abstract
Young adult caregivers (YACs) of older adults are an often-overlooked subset of the caregiver population, though they make up more than a quarter of all caregivers. Because of their stage in life and their economic and work status, YACs (ages 21 to 40) are likely to face different caregiving challenges than other age cohorts of caregivers. Using the life course perspective and role conflict theory as foundational frameworks, this article compares the resources and strains of YACs with those of their middle-age caregiver (MAC) (ages 41 to 60) and older adult caregiver (OAC) (ages 61 and older) counterparts. Authors used data from a cross-sectional pilot study of caregivers recruited across one western state through community agencies. Through multivariate regression analysis, findings indicated that YACs reported more financial strain than MACs and OACs, despite being more likely to be employed. In contrast, YACs reported greater positive feelings toward caregiving than both MACs and OACs. These findings remained while controlling for employment status, education, and hours per week spent caregiving. Although YACs may find great value in caregiving, they may also be in more financially precarious situations. The article concludes with recommendations for caregiver support programs to reach YACs in the workplace.
Site of Occlusion May Influence Decision to Perform Thrombectomy Under General Anesthesia or Conscious Sedation
Authors: Steinberg Jeffrey A. , Somal Jaspreet , Brandel Michael G. , Kang Keiko M. , Wali Arvin R. , Rennert Robert C. , Santiago-Dieppa David R. , Olson Scott E. , Pannell J. Scott , Khalessi Alexander A. 
Published: September 2019

Background:
Although mechanical thrombectomy has become the standard of care for large-vessel occlusion, the role of conscious sedation versus general anesthesia (GA) with intubation during thrombectomy remains controversial. Aphasia may increase patient agitation or apparent uncooperativeness/confusion and thereby lead to higher use of GA. The purpose of this study was to identify risk factors for GA and determine if the side of vessel occlusion potentially impacts GA rates.

Materials and Methods:
Patients who underwent mechanical thrombectomy of the middle cerebral artery (MCA) for acute ischemic stroke at our institution between April 2014 and July 2017 were retrospectively reviewed. Patient characteristics, procedural factors, and outcomes were assessed using multivariate regression analyses. Mediation analysis was utilized to investigate whether aphasia lies on the causal pathway between left-sided MCA stroke and GA.

Results:
Overall, 112 patients were included: 62 with left-sided and 50 with right-sided MCA occlusion. Patients with left-sided MCA occlusion presented with aphasia significantly more often those with right-sided occlusion (90.3% vs. 32.0%; P<0.001). GA rates were significantly higher for patients with left-sided compared with right-sided MCA occlusion (45.2% vs. 20.0%; P=0.028). Aphasia mediated 91.3% of the effect of MCA stroke laterality on GA (P=0.02). GA was associated with increased door-to-groin-puncture time (106.4% increase; 95% confidence interval, 24.1%-243.4%; P=0.006) and adverse discharge outcome (odds ratio, 1.04; 95% confidence interval, 1.01-1.07; P=0.019).

Conclusions:
Patients who had a stroke with left-sided MCA occlusion are more likely to undergo GA for mechanical thrombectomy than those with right-sided MCA occlusion. Aphasia may mediate this effect and understanding this relationship may decrease GA rates through modification of management protocols, potentially leading to improved clinical outcomes. Our study suggests that GA should preferentially be considered for the subset of patients with acute ischemic stroke undergoing mechanical thrombectomy for left-sided MCA occlusion.
Optimizing Multisource Feedback Implementation for Australasian Physicians
Authors: Pooley Michael , Pizzuti Carol , Daly Michele 
Published: September 2019

Introduction:
Medical regulatory bodies in Australasia are encouraging greater use of continuing professional development activities, such as multisource feedback (MSF), which are practice-based, include facilitated feedback, and improve performance. The aim of this study was to explore the feasibility, effectiveness, and sustainability of an MSF process that includes a telephone/videoconference debrief, to better design future MSF implementation.

Method:
Thirty-seven Australasian physician participants sought feedback from patients and colleagues and debriefed their feedback report with a trained facilitator. The impact was evaluated using quantitative and qualitative measures including surveys and semistructured interviews.

Results:
The feasibility of the MSF process was impacted by the level of support for the participant to complete the MSF, the nature and location of participants' work, and the use of telephone/videoconference to deliver the debrief. Regarding effectiveness, the MSF stimulated reflection on practice and action on areas identified for improvement. In addition, the quality of rater feedback and the inclusion of a debrief impacted participant and facilitator reports of effectiveness. The absence of a culture of feedback, the formative nature of the MSF, and the confidentiality of the results were factors impacting sustainability.

Discussion:
Optimizing MSF is important to encourage broad uptake in the wider medical community in Australasia. Although several factors were identified as having an impact, it is clear that inclusion of a quality debrief will increase the perceived value and the effectiveness of MSF. Delivering that debrief through telephone/videoconference can be effective and will increase the overall feasibility and sustainability.
Right ventricular–pulmonary arterial uncoupling in mild-to-moderate systemic hypertension
Authors: Vriz Olga , Pirisi Mario , Bossone Eduardo , Fadl ElMula Fadl ElMula Mohammed , Palatini Paolo , Naeije Robert 
Published: September 2019

Background:
Mild-to-moderate hypertension with preserved left ventricular (LV) function may be associated with right ventricular (RV) dysfunction and increased pulmonary vascular resistance (PVR).

Methods:
The present study explored the adequacy of RV–pulmonary arterial (PA) coupling in 211 never-treated hypertensive patients (mean blood pressure, BP 112 ± 12 mmHg) and 246 controls (BP 93 ± 12 mmHg). They underwent a comprehensive transthoracic Doppler echocardiography, and RV–PA coupling was estimated by the tricuspid annular plane systolic excursion (TAPSE) to systolic pulmonary artery pressure (PASP) ratio (TAPSE/PASP).

Results:
Compared with the controls, hypertensive patients had increased LV wall thickness and decreased trans-mitral E/A with only slight but significant increase in transmitral Doppler E wave to tissue Doppler mitral annulus e′ wave ratio (6.3 ± 1.9 vs. 5.8 ± 1. 5, P < 0.05). RV dimensions and indices of either systolic or diastolic function were not different. PASP was increased in the hypertensive patients (25 ± 7 vs. 21 ± 7 mmHg, P < 0.001), as was PVR estimated from the tricuspid regurgitation velocity to right ventricular outflow tract velocity ratio (1.7 ± 0.4 vs. 1.5 ± 0.5 Wood units, P < 0.001). The TAPSE/PASP ratio was decreased (1.08 ± 0.35 vs. 1.43 ± 0.67 mm/mmHg, P < 0.001). This difference was mainly driven by male hypertensive patients. At multivariable analysis, the only independent predictors of decreased TAPSE/PASP were age and blood pressure.

Conclusion:
The TAPSE/PASP is markedly decreased in hypertension without heart failure, chiefly in men, with only slight increases in estimates of LV filling pressure or PVR, suggesting RV–PA uncoupling.
Making a Correct Diagnosis of Glaucoma: Data From the EMGT
Authors: Öhnell HannaMaria , Bengtsson Boel , Heijl Anders 
Published: September 2019

Précis:
A correct diagnosis of glaucoma established at initial visits.

Purpose:
It has been suggested that a diagnosis of glaucoma cannot be certain until progression has been demonstrated. Our aim was to evaluate the correctness of a glaucoma diagnosis established after 2 initial visits.

Patients and Methods:
Patients included in the Early Manifest Glaucoma Trial (EMGT) who had continued follow-up for at least 15 years were included in this analysis. The patients had been recruited primarily through a population screening and were diagnosed with glaucoma if the Glaucoma Hemifield Test was outside normal limits in the same sector at two consecutive visits. A Glaucoma Hemifield Test classification of borderline was also diagnostic if corresponding optic disc findings were present. At least one of the following criteria had to be fulfilled during follow-up to confirm the initial diagnosis: (1) visual field progression in at least one eye according to the EMGT criterion; (2) development of manifest glaucoma in an initially ineligible fellow eye; (3) optic disc progression in at least one eye; (4) optic disc hemorrhages in at least 1 eye.

Results:
Of the 255 patients included in the EMGT, 117 were followed for at least 15 years, representing 147 eyes eligible for our study. During follow-up, 134 eyes (91%) showed visual field progression, and, of the remaining 13 eyes, only 4 (3%) did not fulfill any of the criteria to confirm the diagnosis.

Conclusions:
A diagnosis made applying strict criteria to 2 initial visual field tests, supported by optic disc findings if visual field findings were borderline, was almost always correct.
Potential Association of Doxycycline With the Onset of Primary Sclerosing Cholangitis: A Case Series
Authors: Buness James Gage , Ali Ahmad Hassan , Tabibian James H. , Buness Cynthia W. , Cox Kenneth L. , Lindor Keith D. 
Published: September 2019

Background:
Primary sclerosing cholangitis (PSC) is linked to inflammatory bowel diseases (IBD). Evidence suggests an association between the gut microbiome and PSC. However, the putative relationship between exposure to antibiotics and onset of PSC has never been reported. We observed 3 cases in which patients without antecedent liver or bowel issues developed symptoms leading to diagnosis of IBD and subsequently PSC after being exposed to doxycycline. We aimed to identify, through the PSC Partners national patient registry, additional cases of PSC in which there is a temporal relationship between exposure to doxycycline and onset of PSC or PSC-IBD.

Areas of Uncertainty:
The etiopathogenesis of PSC remains an enigma.

Data Sources:
We collected data from patients with PSC and PSC-IBD in which there seemed to be a temporal relationship between exposure to doxycycline and PSC. Time from doxycycline exposure to: (1) onset of PSC or PSC-IBD symptoms and (2) diagnosis of PSC were documented for each patient. Descriptive statistical analyses were performed.

Results:
We identified 6 additional patients with PSC or PSC-IBD in whom there was a temporal relationship between exposure to doxycycline and onset of PSC or PSC-IBD. The median age of these 9 patients was 20 years, 6 were female, and 7 had ulcerative colitis. The median time from doxycycline exposure to onset of first symptoms was 3 months, and median time from doxycycline exposure to diagnosis of PSC was 15 months.

Therapeutic Hypothesis:
We describe 9 cases of PSC and PSC-IBD in which there seem to be a temporal relationship between exposure to doxycycline and onset of PSC.