bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring of pyrethroid resistance in Aedes aegypti: first report of double and triple kdr mutations in Buenos Aires Province
Authors: Barrera-Illanes Alberto N. , Ledesma Lorena , Alvarez-Costa Agustin , Balsalobre Agustín , Toloza Corina Juliana , Hernandez-Maiztegui Agustín , Jait Andrea , Sierra Ivana , Micieli María Victoria , Manteca-Acosta Mariana , Ons Sheila 
Published: November 2024

Abstract
Background
Dengue is an emerging disease in Argentina due to the colonization of Aedes aegypti, the mosquito vector. Buenos Aires Province is the biggest and most populated district in Argentina, suffering dengue outbreaks of growing magnitude. During epidemic periods, pyrethroid insecticides are used in this country to control adult mosquitoes. Pyrethroid resistance in dengue vectors has been reported worldwide, making it necessary to implement resistance management strategies. The voltage-gated sodium channel is the target site of pyrethroids. Mutations in the gene encoding this protein, called kdr mutations, are usually the molecular cause of pyrethroid resistance in insects. In Ae. aegypti from the Americas, three kdr substitutions were described: V410L, V1016I, and F1534C. The diagnostic of kdr mutations is recommended for the early detection of pyrethroid resistance as well as the consequent planning of evidence-based control policies.

Methods
We distributed ovitraps across 16 localities in Buenos Aires Province, collecting 22,123 eggs. A total of 522 mosquitoes were genotyped in positions 1016 and 1534 of voltage-gated channel using multiplex high-resolution melting and/or TaqMan probe methods. A subset of 449 samples was also genotyped by a singleplex high-resolution melting method developed ad hoc and/or Sanger sequencing.

Results
We have documented, for the first time to our knowledge in the central region of Argentina, the presence of the 1016Ikdr + 1534Ckdr allele. Additionally, our study reports the first identification of the V410L mutation in central Argentina. These results underscore a growing trend of pyrethroid resistance in Ae. aegypti, fueled by the widespread use of these insecticides.

Conclusions
We detected 1016Ikdr + 1534Ckdr and 410Lkdr mutations in central Argentina for the first time and improved the processivity and accuracy of kdr genotyping methods. The results are both a tool for resistance monitoring and a sign of alarm to direct efforts towards finding sustainable methods for vector control to complement or replace pyrethroids. Joint efforts between academia and authorities to develop and implement public policies for vector control are a productive way to transfer scientific results for their application in public health.

Graphical Abstract
Protocol for a randomized controlled trial with a stepped care approach, utilizing PrEP navigation with and without contingency management, for transgender women and sexual minority men with a substance use disorder: Assistance Services Knowledge-PrEP (A.S.K.-PrEP)
Authors: Reback Cathy J. , Landovitz Raphael J. , Benkeser David , Jalali Ali , Shoptaw Steven , Li Michael J. , Mata Raymond P. , Ryan Danielle , Jeng Philip J. , Murphy Sean M. 
Published: November 2024

Abstract
Background
In the United States, most (~ 70%) annual newly diagnosed HIV infections are among substance-using sexual minority men (SMM) and gender minority transgender women (trans women). Trans women and SMM are more likely to report or be diagnosed with a substance use disorder (SUD) than their cisgender or heterosexual counterparts and the presence of an SUD substantially increases the risk of HIV infection in both groups. Although Pre-Exposure Prophylaxis (PrEP) is highly effective, initiation, adherence, and persistence are exclusively behavioral outcomes; thus, the biomedical benefits of PrEP are abrogated by substance use. SUD is also associated with reduced quality-of-life, and increased overdose deaths, utilization of high-cost healthcare services, engagement in a street economy, and cycles of incarceration.

Objective
To determine the optimal (considering efficacy and cost-effectiveness) strategy for advancement along the PrEP Care Continuum among trans women and SMM with an SUD.

Methods
This study will implement a randomized controlled trial, evaluating two Stepped Care approaches involving A.S.K.-PrEP vs. standard of care (SOC) to determine optimal intervention strategies for trans women and SMM with an SUD (N = 250; n = 83 trans women; n = 167 SMM) for advancement along the PrEP Care Continuum. Participants will be randomized (3:1) to Stepped Care (n = 187) or SOC (n = 63). Participants in the Stepped Care arm will be assessed at 3-months for intervention response; responders will be maintained in A.S.K.-PrEP, while non-responders will receive added attention to their SUD via Contingency Management (CM). Non-responders will be re-randomized (1:1) to either (a) receive A.S.K.-PrEP + CM, or (b) shift the primary focus to their SUD (CM alone).

Results
Recruitment and enrollment began in May 2023. Recruitment will span approximately 36 months. Data collection, including all follow-up assessments, is expected to be completed in April 2027.

Discussion
Trans women and SMM with an SUD have the two highest HIV prevalence rates in the United States, which underscores the urgent need for effective measures to develop scalable behavioral interventions that can encourage advancement along the PrEP Care Continuum. To improve public health, researchers must identify scalable and cost-effective behavioral interventions to promote PrEP initiation, adherence, and persistence among trans women and SMM who use substances.

Trial registration
This trial has been registered at ClinicalTrials.gov under the number NCT05934877.
Virtual reality-based retrospective think aloud (VR-RTA): a novel method for studying offender decision-making
Authors: Sergiou Carmen-Silva , Gerstner Dominik , Nee Claire , Elffers Henk , van Gelder Jean-Louis 
Published: November 2024

Abstract
Objectives
This article describes and tests a novel multi-method approach to examine decision-making: Virtual Reality-Based Retrospective Think-Aloud (VR-RTA). The VR-RTA method taps into the offender perspective and aims to enhance memory recall and information elicitation.

Methods
We applied VR-RTA among a sample of incarcerated burglars (N = 200) who scouted virtual neighborhoods to explore opportunities for burglary in immersive VR equipped with integrated eye tracking. Subsequently, they viewed a screen recording of their scouting process and simultaneously “thought aloud” about their assessment of the environment and decision-making strategies. Emerging themes were then further examined in an interview and linked to survey data. Recorded eye tracking data were used to examine burglars’ attention towards environmental features to identify deterrent and attracting cues, and were triangulated with the survey and interview data.

Results
Rich and detailed insights into participants’ interpretation of the environment and their decision-making strategies were obtained. VR-RTA assisted in verbalizing automated cognitive processes and increased participant engagement by building rapport.

Conclusions
As a multi-method approach able to capture in-the-moment considerations underlying decision-making during crime commission, VR-RTA offers potential to develop into an important tool for crime research. It is able to both overcome limitations of studies using retrospective methods, such as interviews and surveys, and contribute to the nascent field of criminological research using immersive technologies.
New insights into CAR T-cell hematological toxicities: manifestations, mechanisms, and effective management strategies
Authors: Yang Yuanyuan , Peng Hongwei , Wang Jianxiang , Li Fei 
Published: November 2024

AbstractChimeric antigen receptor (CAR) T-cell therapy represents a highly efficacious treatment modality demonstrated to enhance outcomes in patients afflicted with malignancies, particularly those enduring relapsed or refractory hematological malignancies. However, the escalating adoption of CAR T-cell therapy has unveiled several life-threatening toxicities, notably cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), infections, and hematological toxicities (HTs), thereby hindering the broad implementation of CAR T-cell therapy. HTs encompass a spectrum of adverse effects, including cytopenias, hemophagocytic lymphohistiocytosis (HLH), coagulopathies, and B-cell aplasia. While our comprehension of the underlying mechanisms governing CRS and ICANS is advancing, the intricate pathophysiology of HTs remains inadequately elucidated. Such knowledge gaps may precipitate suboptimal therapeutic decisions, potentially culminating in substantial medical resource depletion and detriment to patients’ quality of life. In this comprehensive review, based on recent updated findings, we delineate various mechanisms contributing to HTs subsequent to CAR T-cell therapy, explicate manifestations of HTs, and proffer strategic interventions to mitigate this relevant clinical challenge.
Pilot evaluation on an adapted tele-behavioral activation to increase physical activity in persons with depression: a single-arm pilot study
Authors: Rethorst Chad D. , Trombello Joseph M. , Chen Patricia M. , Carmody Thomas J. , Goodman Lynnel C. , Lazalde Alejandra , Trivedi Madhukar H. 
Published: November 2024

Abstract
Background
Physical activity has the potential to improve physical and mental health outcomes of persons with depression. However, feasible and acceptable strategies to integrate physical activity interventions into real-world settings are needed.

Objective
To assess the feasibility and acceptability of a manualized Behavioral Activation intervention aimed to increase physical activity in persons with depression (defined as a PHQ-9 score ≥ 10).

Methods
A single-arm pilot study was conducted. The intervention consisted of 8 tele-therapy sessions delivered over a 10-week period. Measures of feasibility included screening, enrollment, intervention adherence, outcome data availability, and intervention fidelity. Acceptability was assessed with a post-intervention survey and qualitatively through focus groups and interviews. Preliminary efficacy of the intervention was assessed by evaluating pre-to-post changes in physical activity and depressive symptoms.

Results
All feasibility metrics exceeded predetermined feasibility goal metrics with the exception of Fitbit wear and screening rate, which was due to a greater than anticipated enrollment rate. Participants (n = 15) reported perceived benefits from the intervention and convenience in attending tele-therapy sessions. Depressive symptoms, as measured by the PHQ-9 improved (16.8 at enrollment to 10.1 post intervention, Cohen’s d = 1.13). Self-reported moderate-to-vigorous physical activity (MVPA) increased from 22.0 min/week at baseline to 36.67 min/week post-intervention (d = 0.58). Physical activity as measured by the Fitbit showed little change (daily step 5543.29 during Week 1 to 6177.48 during Week 10, (d = 0.14); MVPA 21.23 min/week during Week 1 to 19.22 at Week 10 (d = 0.0.06).

Conclusions
Results of the pilot study suggest the intervention is feasible to deliver and acceptable to participants. Preliminary results suggest the intervention may be effective in improving depressive symptoms and increasing self-reported physical activity.

Trial registration
ClinicalTrials.gov NCT04990401, Registered July 21, 2021.
Self-reported Health Problems of Professional Dancers from Five German Opera Houses or State Theatres: A Prospective Study with Weekly Follow-ups during One Season
Authors: Junge Astrid , van Rijn Rogier M , Stubbe Janine H , Hauschild Anja 
Published: November 2024

Abstract
Background
Most studies on injuries of professional dancers used a medical-attention and/or time-loss definition and did not analyse all health problems. Further, almost all studies included just one company. The aim was to analyse all self-reported health problems of professional ballet and contemporary dancers during one season and compare sexes and five companies in Germany.

Methods
Dancers of five professional companies completed weekly health questionnaires during the season (September 2022 to June 2023). Numerical rating scales were used for severity of all health problems, musculoskeletal pain, impairment of the ability to dance at full potential, physical and mental workload in the previous seven days. If the severity of all health problems were rated greater than “0”, the dancers were asked to report the type and consequences of their most severe health problem.

Results
During 43 weeks, 98 dancers (39.8% male) completed 3123 weekly reports (response rate 74.1%). The season prevalence of any health problem was 100% and of time-loss health problems 74.5%. The average weekly prevalence of any health problem was 62.7%, of musculoskeletal pain 83.4% and of impaired ability to dance at full potential, due to health problem 48.6%. While the season prevalence and type of health problems was similar between sexes, the average weekly prevalence of severe health problems was higher in female than in male dancers (Chi2 = 23.2; p < .001), and female dancers saw a qualified health professional more often than male dancers (Chi2 = 19.5; p < .001). Companies differed in almost all investigated variables, with more health problems in companies where more dancers rated their workload higher than “ideal”.

Conclusion
Health problems are frequent in professional dancers and affect their ability to dance. Future studies should analyse the impact of physical and mental workload on health problems.
The Effect of Specific Strength Training on Throwing Velocity in Overarm Throwing: A Systematic Review
Authors: Fredriksen Andrea Bao , van den Tillaar Roland 
Published: November 2024

Abstract
Background
Throwing velocity is an important research topic in sports science, and it is an essential performance variable for athletes in overarm-throwing sports like baseball, team handball, water polo, softball, and cricket. The aim of the present review was to investigate the effect of specific strength training on throwing velocity for overarm throws.

Methods
The literature was analysed using the Preferred Reporting Items for Systematic reviews and Meta-analyses, searching in SPORTDiscus and MEDLINE. Seventeen studies were included in this review, and the training studies were divided into four categories: (a) overweight and underweight balls, (b) forearm loading, (c) pulley device training, and (d) strength training with a resistance band.

Results
All strength training studies with resistance band and the forearm loading categories increased the throwing velocity, varying from 3.7 to 26%. However, only half of these studies found that training was associated with a significantly higher increase versus the control group. Findings were inconsistent in other categories.

Conclusion
Based on the findings of the present review, no clear conclusion can be made on which of the specific strength training methods is best for increasing throwing velocity. However, some recommendations can be offered. Firstly, the throwing training period should be long enough (≥ 6 weeks) with a high enough workload. Throwing training with a resistance band increases throwing velocity significantly for junior and less experienced overarm-throwing athletes. Furthermore, throwing with underweighted balls of similar size will ensure a positive effect on throwing velocity. Also, throwing training with combined over- and underweighted balls can be used if the overweighted balls are carefully selected to ensure there is no negative impact on throwing kinematics and injuries. For the other categories, the results were conflicting. Furthermore, due to the low number of studies in the pulley device and forearm loading categories, more studies should be conducted to investigate their effects on throwing velocity.
Immunohistochemical Status Predicts Pathologic Complete Response to Neoadjuvant Therapy in HER2-Overexpressing Breast Cancers
Authors: Winer Leah , Ruth Karen J. , Bleicher Richard J. , Nagarathinam Rajeswari , McShane Melissa , Porpiglia Andrea S. , Pronovost Mary T. , Aggon Allison , Williams Austin D. 
Published: November 2024

Abstract
Background
Human epidermal growth factor receptor 2 (HER2) overexpression (HER2+) is defined by immunohistochemistry (IHC) and in situ hybridization (ISH) as IHC3+ or IHC2+/ISH+. Response differences to neoadjuvant anti-HER2 therapy (NT) in IHC3+ versus IHC2+/ISH+ breast cancer patients are poorly characterized. We explored whether pathologic complete response (pCR) varies by HER2 IHC status.

Methods
Patients with stage I–III HER2+ breast cancer undergoing NT and surgery between 2013 and 2020 were identified from the National Cancer Database and stratified by IHC status. Breast and nodal pCR were analyzed.

Results
Of 40,711 HER2+ patients, 83% were IHC3+ and 17% were IHC2+/ISH+. IHC3+ patients were more likely to be hormone receptor (HR)-negative (33 vs. 21%), have cT3/4 tumors (24 vs. 21%), and be cN+ (52 vs. 47%; all p < 0.0001). Breast conservation rates were similar (each 43%, p = 0.32), although IHC3+ axillary lymph node dissection rates were lower (41 vs. 45%, p < 0.0001). Among all patients, breast pCR was 49%, while nodal pCR was 64%. Compared with IHC2+/ISH+, IHC3+ had higher unadjusted breast (54 vs. 22%, p < 0.0001) and nodal (69 vs. 37%, p < 0.0001) pCR rates. When stratified by HR status, pCR was lower for HR+ disease but remained higher among IHC3+ patients. Analysis of T1cN0 primaries mirrored these trends. In multivariable analysis, IHC3+ remained an independent predictor of breast (odds ratio [OR] 3.91, confidence interval [CI] 3.65–4.19, p < 0.0001) and nodal (OR 3.40, CI 3.12–3.71, p < 0.0001) pCR.

Conclusion
HER2 IHC status predicts pCR and may help select breast cancer patients who derive the greatest benefit from NT. These findings provide further evidence that revision of HER2 classification may improve clinical management.
Exploring the integration of Generative AI in assessment in a tertiary context
Authors: Petraki Eleni 
Published: November 2024

The unprecedented advancements of Generative Artificial Intelligence (GenAI) tools have generated controversies surrounding their potential for transforming educational practices, and democratising knowledge sharing, while acknowledging risks to current educational practices. In order to understand the potential and risks of GenAI tools on educational practices, recent research point to the need to develop student and teacher AI literacy skills and to investigate the impact of GenAI integration in learning and assessment practices. In addressing the call for more research in the field, this study reports on the integration of GenAI tools in an academic assessment in a postgraduate course for pre-service language teachers at an Australian university. Data were collected from students’ reflections of their adoption of GenAI tools for planning their assessment and from qualitative surveys. Thematic analysis was employed to identify students’ perceived challenges and benefits in adopting GenAI for essay writing. Pre-service teachers recognised benefits in adopting GenAI for planning and generating ideas for academic writing but recognised the importance of mitigating risks created by inaccuracies or biases in content. The findings confirm the importance of transparency in the integration of GenAI and developing student awareness of and training in ethical use of GenAI for higher education.
On the move: social and linguistic acculturation in a small society
Authors: Baider Fabienne , Karpava Sviatlana 
Published: November 2024

Abstract
This study examines the ways in which non-nationals in the Republic of Cyprus perceive the phenomenon of acculturation, and looks at the factors that affect their integration. Our methodology comprised questionnaires and interviews to collect data, which we then interpreted through discourse analysis. Our findings include some expected results; namely, that immigrants’ perception of their status in Cyprus society is largely affected, and mainly negatively, by their degree of fluency in the local language (Greek), as this strongly impacts their social networks and thus opportunities for integration. However, there are other influential factors, such as socioeconomic status, mother tongue (L1) and ethnicity, and a willingness to integrate. Interestingly, the feeling of being integrated is also related to formal procedures, such as having the national citizenship and holding a Cyprus passport.
On a discrete version of Fejér inequality for α-convex sequences without symmetry condition
Authors: Jleli Mohamed , Samet Bessem 
Published: November 2024

Abstract
In this study, we introduce the notion of

α

\alpha

-convex sequences which is a generalization of the convexity concept. For this class of sequences, we establish a discrete version of Fejér inequality without imposing any symmetry condition. In our proof, we use a new approach based on the choice of an appropriate sequence, which is the unique solution to a certain second-order difference equation. Moreover, we obtain a refinement of the standard (right) Fejér inequality for convex sequences.