bluuebunny/crossref_metadata_2025_split huggingface dataset:
La coopétition, une nouvelle approche stratégique pour mieux gérer les relations entre PME et distributeurs
Authors: Ambroise Laure , Fleck Nathalie , Lefebvre Clarinda 
Published: December 2018

Cet article analyse les éléments constitutifs de la relation entre un fabricant et ses distributeurs et se propose d’envisager la coopétition comme cadre d’analyse permettant aux managers de PME de définir simultanément des stratégies de relations et de coopération différenciées selon les distributeurs. Une étude longitudinale menée sur 5 ans auprès d’une PME alimentaire bio met en évidence le réseau de relations ainsi que les niveaux de conflit, concurrence et de coopération vis-à-vis de ses distributeurs, généralistes et spécialisés. Les résultats confirment que l’approche coopétitive permet d’identifier une modalité hybride des relations verticales à différents niveaux de la chaine d’activité du canal de distribution. Ils mettent également en évidence comment des dirigeants de PME peuvent gérer leur offre produits (choix d’assortiment, produits exclusifs, etc.) et leur portefeuille de marques (marques exclusives, marques de distributeurs, etc.) selon les distributeurs de façon à appréhender cette situation de façon agile et assurer la pérennité de leur entreprise, en fonction de critères économiques mais également liés au partage de valeurs et à une vision du marché.
Mieux comprendre les difficultés de développement du doggy bag en France : une analyse par l’approche des représentations sociales
Authors: Achabou Mohamed Akli , Dekhili Sihem , Tagbata Didier 
Published: December 2018

Cet article s’attache à comprendre les représentations liées au doggy bag et la manière dont elles déterminent l’adoption de cette pratique comme un moyen de lutte contre le gaspillage alimentaire. À l’aide d’une double approche reposant sur des entretiens individuels auprès de consommateurs et de restaurateurs français, cette recherche identifie les freins à l’adoption de cette pratique. Ceux-ci se regroupent autour de deux volets : 1) des freins « matériels » qui se rapportent à la faible praticité du doggy bag pour le client, au risque sanitaire, au manque d’efficacité perçue de cette pratique sur le plan environnemental, et au coût supplémentaire de l’emballage ; et 2) des freins liés à la culture et aux normes sociales. Les résultats permettent également de préciser des leviers pour encourager la mise en place d’une telle pratique dans le contexte français.
Renal mineralocorticoid receptor expression is reduced in lipoatrophy
Authors: Toffoli Barbara , Bernardi Stella , Winkler Carine , Carrascosa Coralie , Gilardi Federica , Desvergne Béatrice 
Published: December 2018

Obesity is a condition characterized by adipose tissue hypertrophy; it is estimated that the obesity epidemic accounted for 4 million deaths in 2015 and that 70% of these were due to cardiovascular disease (CVD). One of the mechanisms linking obesity to CVD is the ability of adipose tissue to secrete circulating factors. We hypothesized that adipose tissue and its secretory products may influence mineralocorticoid receptor (MR) expression. Here, we showed that expression of MR and its downstream targets (Cnksr3, Scnn1b, and Sgk1) were significantly reduced in the kidneys of peroxisome proliferator‐activated receptor‐γ null (PpargΔ/Δ) and A‐ZIP/F‐1 (AZIPtg/+) lipoatrophic mice with respect to their controls. Intriguingly, MR expression was also found to be significantly reduced in the kidneys of genetically obese ob/ob mice. Our data suggest that adipose tissue contributes to the regulation of MR expression. Given that leptin deficiency seems to be the major feature shared by PpargΔ/Δ, AZIPtg/+, and ob/ob mice, we speculate that adipose tissue modulates MR expression through the leptin system.
Theory of the Lamb Shift in Hydrogen and Light Hydrogen‐Like Ions
Authors: Yerokhin Vladimir A. , Pachucki Krzysztof , Patkóš Vojtěch 
Published: December 2018

AbstractTheoretical calculations of the Lamb shift provide the basis required for the determination of the Rydberg constant from spectroscopic measurements in hydrogen. The recent high‐precision determination of the proton charge radius drastically reduces the uncertainty in the hydrogen Lamb shift originating from the proton size. As a result, the dominant theoretical uncertainty now comes from the two‐ and three‐loop QED effects, which calls for further advances in their calculations. The present status of theoretical calculations of the Lamb shift in hydrogen and light hydrogen‐like ions with the nuclear charge number up to is reviewed. Theoretical errors due to various effects are critically examined and estimated.
Safety and efficacy of high‐dose methotrexate for osteosarcoma in adolescents compared with young adults
Authors: Wippel Brittany , Gundle Kenneth R. , Dang Theresa , Paxton Jillian , Bubalo Joseph , Stork Linda , Fu Rongwei , Ryan Christopher W. , Davis Lara E. 
Published: December 2018

AbstractBackgroundDoxorubicin, cisplatin, and high‐dose methotrexate (HDMTX) are the backbone of pediatric osteosarcoma treatment. However, due to toxicity concerns and the lack of data regarding efficacy in adults, high‐dose methotrexate is rarely used in the adult population.MethodsThis single‐center retrospective study examined 33 patients who received HDMTX (12 g/m2, maximum 20 g) for the treatment of osteosarcoma at Oregon Health and Science University (OHSU) from 2011 to 2017. Time to serum methotrexate level ≤0.1 µmol/L was the primary outcome. Secondary outcomes included number of HDMTX doses received, methotrexate‐related toxicities, and disease outcomes including histologic response at resection and metastasis‐free survival.ResultsMedian age was 20 years [range 7‐38]; 14 patients ≤18 years old and 19 patients >18 years old. Median time to clearance for patients ≤18 years was 79 hours (range 63‐116) compared to 120 hours (range 77‐315) for patients >18 years (P < 0.001). No correlation between age and histologic response at resection was observed (P = 0.50), but there was a significant positive correlation between the number of HDMTX doses received before resection and histologic response (r = 0.49, P = 0.006). There was no significant difference in metastasis‐free survival between age groups, although a trend toward improved survival was noted for patients who received at least seven doses of HDMTX.ConclusionAge over 18 years correlates with delayed methotrexate clearance and fewer administered doses of methotrexate, without increased toxicity. The potential benefit of HDMTX in young adults with osteosarcoma may outweigh toxicity risks.
Symbiont type and environmental factors affect transcriptome‐wide gene expression in the coral Montipora capitata
Authors: Helmkampf Martin , Bellinger M. Renee , Frazier Monika , Takabayashi Misaki 
Published: December 2018

AbstractReef‐building corals may harbor genetically distinct lineages of endosymbiotic dinoflagellates in the genus Symbiodinium, which have been shown to affect important colony properties, including growth rates and resilience against environmental stress. However, the molecular processes underlying these differences are not well understood. In this study, we used whole transcriptome sequencing (RNA‐seq) to assess gene expression differences between 27 samples of the coral Montipora capitata predominantly hosting two different Symbiodinium types in clades C and D. The samples were further characterized by their origin from two field sites on Hawai‘i Island with contrasting environmental conditions. We found that transcriptome‐wide gene expression profiles clearly separated by field site first, and symbiont clade second. With 273 differentially expressed genes (DEGs, 1.3% of all host transcripts), symbiont clade had a measurable effect on host gene expression, but the effect of field site proved almost an order of magnitude higher (1,957 DEGs, 9.6%). According to SNP analysis, we found moderate evidence for host genetic differentiation between field sites (FST = 0.046) and among corals harboring alternative symbiont clades (FST = 0.036), suggesting that site‐related gene expression differences are likely due to a combination of local adaptation and acclimatization to environmental factors. The correlation between host gene expression and symbiont clade may be due to several factors, including host genotype or microhabitat selecting for alternative clades, host physiology responding to different symbionts, or direct modulation of host gene expression by Symbiodinium. However, the magnitude of these effects at the level of transcription was unexpectedly small considering the contribution of symbiont type to holobiont phenotype.
Behavioral classification of low‐frequency acceleration and temperature data from a free‐ranging small mammal
Authors: Studd Emily K. , Landry‐Cuerrier Manuelle , Menzies Allyson K. , Boutin Stan , McAdam Andrew G. , Lane Jeffrey E. , Humphries Murray M. 
Published: December 2018

AbstractThe miniaturization and affordability of new technology is driving a biologging revolution in wildlife ecology with use of animal‐borne data logging devices. Among many new biologging technologies, accelerometers are emerging as key tools for continuously recording animal behavior. Yet a critical, but under‐acknowledged consideration in biologging is the trade‐off between sampling rate and sampling duration, created by battery‐ (or memory‐) related sampling constraints. This is especially acute among small animals, causing most researchers to sample at high rates for very limited durations. Here, we show that high accuracy in behavioral classification is achievable when pairing low‐frequency acceleration recordings with temperature. We conducted 84 hr of direct behavioral observations on 67 free‐ranging red squirrels (200–300 g) that were fitted with accelerometers (2 g) recording tri‐axial acceleration and temperature at 1 Hz. We then used a random forest algorithm and a manually created decision tree, with variable sampling window lengths, to associate observed behavior with logger recorded acceleration and temperature. Finally, we assessed the accuracy of these different classifications using an additional 60 hr of behavioral observations, not used in the initial classification. The accuracy of the manually created decision tree classification using observational data varied from 70.6% to 91.6% depending on the complexity of the tree, with increasing accuracy as complexity decreased. Short duration behavior like running had lower accuracy than long‐duration behavior like feeding. The random forest algorithm offered similarly high overall accuracy, but the manual decision tree afforded the flexibility to create a hierarchical tree, and to adjust sampling window length for behavioral states with varying durations. Low frequency biologging of acceleration and temperature allows accurate behavioral classification of small animals over multi‐month sampling durations. Nevertheless, low sampling rates impose several important limitations, especially related to assessing the classification accuracy of short duration behavior.
Fine‐root traits are linked to species dynamics in a successional plant community
Authors: Caplan Joshua S. , Meiners Scott J. , Flores‐Moreno Habacuc , McCormack M. Luke 
Published: December 2018

AbstractDespite the importance of fine roots for the acquisition of soil resources such as nitrogen and water, the study of linkages between traits and both population and community dynamics remains focused on aboveground traits. We address this gap by investigating associations between belowground traits and metrics of species dynamics. Our analysis included 85 species from a long‐term data set on the transition from old field to forest in eastern North America (the Buell‐Small Succession Study) and the new Fine‐Root Ecology Database. Given the prominent roles of life form (woody vs. non‐woody) and species origin (native vs. exotic) in defining functional relationships, we also assessed whether traits or their relationships with species dynamics differed for these groups. Species that reached their peak abundance early in succession had fine‐root traits corresponding to resource acquisitive strategies (i.e., they were thinner, less dense, and had higher nitrogen concentrations) while species that peaked progressively later had increasingly conservative strategies. In addition to having more acquisitive root traits than native species, exotics diverged from the above successional trend, having consistently thinner fine roots regardless of the community context. Species with more acquisitive fine‐root morphologies typically had faster rates of abundance increase and achieved their maximal rates in fewer years. Decreasing soil nutrient availability and increasing belowground competition may become increasingly strong filters in successional communities, acting on root traits to promote a transition from acquisitive to conservative foraging. However, disturbances that increase light and soil resource availability at local scales may allow acquisitive species, especially invasive exotics, to continue colonizing late into the community transition to forest.
Progression of glucose‐lowering diabetes therapy in TECOS
Authors: Bethel M. Angelyn , Engel Samuel S. , Stevens Susanna R. , Lokhnygina Yuliya , Ding Jie , Josse Robert G. , Alvarsson Michael , Hramiak Irene , Green Jennifer B. , Peterson Eric D. , Holman Rury R. ,   on behalf of the TECOS Study Group
Published: December 2018

SummaryAimsTECOS was a randomized, double‐blind, placebo‐controlled trial assessing the impact of sitagliptin vs. placebo on cardiovascular outcomes when added to usual care in patients with type 2 diabetes. We report the use of concomitant diabetes medications and the risk for progression to insulin during follow‐up.Materials and MethodsTECOS enrolled 14 671 participants with HbA1c 6.5%‐8.0% on monotherapy with metformin, pioglitazone, sulfonylurea (SU), or dual therapy with two oral agents or insulin with or without metformin. Subsequent diabetes management was by the participant's usual care physician. Time to initiation of insulin and risk of hypoglycaemia were estimated using Cox proportional hazards models.ResultsThe most common glucose‐lowering regimens at baseline were metformin monotherapy (30.2%), SU monotherapy (8.5%), metformin/SU therapy (35.1%), and insulin with or without metformin (13.9% and 8.6%, respectively). Over a median 3.0 years’ follow‐up, diabetes therapy was intensified in 25.2% of participants (sitagliptin 22.0%, placebo 28.3%). Medications most commonly added were SU (8.3%) or insulin (8.8%). Insulin initiation in the usual care setting occurred at mean (standard deviation) HbA1c of 8.5 (1.5)%. Sitagliptin did not impact rates of severe hypoglycaemia, but delayed progression to insulin when added to metformin or metformin/SU regimens.ConclusionConsistent with the trial's pragmatic design, TECOS participants underwent typical progression of diabetes medications. Sitagliptin was associated with lower HbA1c, without increased risk for severe hypoglycaemia and was associated with delayed progression to insulin when added to metformin with or without SU.
Increased dwell time and occurrence of dsDNA translocation events through solid state nanopores by LiCl concentration gradients
Authors: Bello Julian , Mowla Maksudul , Troise Nicholas , Soyring Joanna , Borgesi Julia , Shim Jiwook 
Published: December 2018

AbstractSolid‐state nanopore based biosensors are cost effective, high‐throughput engines for single molecule detection of biomolecules with the added benefit of size modification. Progress in the translation of the science into a viable diagnostic tool is impeded by inadequate sensitivity of data acquisition systems in detection of fast DNA translocations through the pore. To combat this, slowing the transport of DNA through the nanopore by use of various media or by altering experimental parameters is common. Applying a concentration gradient of KCl in the experimental ionic solution has been shown to effectively prolong dwell times as well as increase the capture rate of DNA by the nanopore. Our previous work has corroborated the ability of LiCl ionic solution to slow down the transport of dsDNA through the nanopore by up to 10‐fold through cation‐DNA interactions. However, this drastically reduced the event occurrence frequency, thus hindering the efficacy of this system as a reliable biosensor downstream. Here, we present the use of a concentration gradient of lithium chloride ionic solution to increase the event frequency of single molecule dsDNA translocation through a solid state nanopore. By using 0.5 M/3 M LiCl on the cis/trans chambers respectively, average dwell times experienced up to a 3‐fold increase when compared to experiments run in symmetric 1 M LiCl. Additionally, experiments using the 0.5 M/3 M displayed a greater than 10‐fold increase in event frequency, confirming the capture propensity of the asymmetric conditions.
Monitoring phase transition of aqueous biomass model substrates by high‐pressure and high‐temperature microfluidics
Authors: Ripken Renée M. , Schlautmann Stefan , Sanders Remco G.P. , Gardeniers Johannes G.E. , Le Gac Séverine 
Published: December 2018

AbstractAqueous‐Phase Reforming (APR) is a promising hydrogen production method, where biomass is catalytically reformed under high pressure and high temperature reaction conditions. To eventually study APR, in this paper, we report a high‐pressure and high‐temperature microfluidic platform that can withstand temperatures up to 200°C and pressures up to 30 bar. As a first step, we studied the phase transition of four typical APR biomass model solutions, consisting of 10 wt% of ethylene glycol, glycerol, xylose or xylitol in MilliQ water. After calibration of the set‐up using pure MilliQ water, a small increase in boiling point was observed for the ethylene glycol, xylitol and xylose solutions compared to pure water. Phase transition occurred through either explosive or nucleate boiling mechanisms, which was monitored in real‐time in our microfluidic device. In case of nucleate boiling, the nucleation site could be controlled by exploiting the pressure drop along the microfluidic channel. Depending on the void fraction, various multiphase flow patterns were observed simultaneously. Altogether, this study will not only help to distinguish between bubbles resulting from a phase transition and/or APR product formation, but is also important from a heat and mass transport perspective.
In‐line coupling of supported liquid membrane extraction across nanofibrous membrane to capillary electrophoresis for analysis of basic drugs from undiluted body fluids
Authors: Dvořák Miloš , Kubáň Pavel 
Published: December 2018

AbstractPlanar polyamide 6 nanofibrous membrane was for the first time used in direct coupling of supported liquid membrane (SLM) extraction to CE analysis. Disposable microextraction device with the nanofibrous membrane was preassembled and stored for immediate use. The membrane in the device was impregnated with 1 µL of 1‐ethyl‐2‐nitrobenzene and the device was subsequently filled with 10 µL of acceptor solution (10 mM HCl) and 15 µL of donor solution (sample). The device was in‐line coupled to CE system for selective extraction and direct injection, separation and quantification of model basic drugs (nortriptyline, haloperidol, loperamide and papaverine) from standard saline solutions (150 mM NaCl) and from undiluted human body fluids (urine and blood plasma). Compared to standard polypropylene supporting material, the nanofibrous membrane demonstrated superior characteristics in terms of lower consumption of organic solvents, constant volumes of operational solutions, full transparency and possibility to preassemble the devices. Extraction parameters were better or comparable for the nanofibrous vs. the polypropylene membrane and the hyphenated SLM‐CE method with the nanofibrous membrane was characterized by good repeatability (RSD ≤ 11.3%), linearity (r2 ≥ 0.9953; 0.5–20 mg/L), sensitivity (LOD ≤ 0.4 mg/L) and transfer (27–126%) of the basic drugs.
Monitoring urban environmental pollution by bivariate control charts: New methodology and case study in Santiago, Chile
Authors: Marchant Carolina , Leiva Víctor , Christakos George , Cavieres M. Fernanda 
Published: December 2018

AbstractParticulate matter (PM) pollution is a serious environmental problem. Santiago of Chile is one of the most polluted cities in the world in terms of PM2.5 and PM10. Monitoring of environmental risk is useful for detecting and preventing adverse effects on human health in highly polluted cities. In this paper, we propose a methodology for monitoring PM pollution in Santiago based on bivariate quality control charts and an asymmetric distribution. A simulation study is carried out to evaluate performance of the proposed methodology. A case study with PM pollution real‐world data from Santiago is provided, which shows that the methodology is suitable to alert early episodes of extreme air pollution. The results are in agreement with the critical episodes reported with the current model used by the Chilean health authority.
Development of temporal lobe epilepsy during maintenance electroconvulsive therapy: A case of human kindling?
Authors: Schotte Caroline , Cleeren Evy , Goffin Karolien , Hunyadi Borbala , Buggenhout Satya , Van Laere Koen , Van Paesschen Wim 
Published: December 2018

SummaryWe describe a patient with new‐onset temporal lobe epilepsy during prolonged maintenance electroconvulsive therapy. We suggest a possible causal relationship with maintenance electroconvulsive therapy through electrical kindling of the temporal lobe.
A genome‐wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine
Authors: Berghuis Bianca , Stapleton Caragh , Sonsma Anja C. M. , Hulst Janic , de Haan Gerrit‐Jan , Lindhout Dick , Demurtas Rita ,   The EpiPGX Consortium, Krause Roland , Depondt Chantal , Kunz Wolfram S. , Zara Federico , Striano Pasquale , Craig John , Auce Pauls , Marson Anthony G. , Stefansson Hreinn , O'Brien Terence J. , Johnson Michael R. , Sills Graeme J. , Wolking Stefan , Lerche Holger , Sisodiya Sanjay M. , Sander Josemir W. , Cavalleri Gianpiero L. , Koeleman Bobby P. C. , McCormack Mark 
Published: December 2018

SummaryObjectiveTo ascertain the clinical and genetic factors contributing to carbamazepine‐ and oxcarbazepine‐induced hyponatremia (COIH), and to carbamazepine (CBZ) metabolism, in a retrospectively collected, cross‐sectional cohort of people with epilepsy.MethodsWe collected data on serum sodium levels and antiepileptic drug levels in people with epilepsy attending a tertiary epilepsy center while on treatment with CBZ or OXC. We defined hyponatremia as Na+ ≤134 mEq/L. We estimated the CBZ metabolic ratio defined as the log transformation of the ratio of metabolite CBZ‐diol to unchanged drug precursor substrate as measured in serum.ResultsClinical and genetic data relating to carbamazepine and oxcarbazepine trials were collected in 1141 patients. We did not observe any genome‐wide significant associations with sodium level in a linear trend or hyponatremia as a dichotomous trait. Age, sex, number of comedications, phenytoin use, phenobarbital use, and sodium valproate use were significant predictors of CBZ metabolic ratio. No genome‐wide significant associations with CBZ metabolic ratio were found.SignificanceAlthough we did not detect a genetic predictor of hyponatremia or CBZ metabolism in our cohort, our findings suggest that the determinants of CBZ metabolism are multifactorial.