bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eribulin, trastuzumab, and pertuzumab as first-line therapy for patients with HER2-positive metastatic breast cancer: a phase II, multicenter, collaborative, open-label, single-arm clinical trial
Authors: Inoue Kenichi , Ninomiya Jun , Saito Tsuyoshi , Okubo Katsuhiko , Nakakuma Takashi , Yamada Hirofumi , Kimizuka Kei , Higuchi Tohru ,   for the SBCCSG-36 investigators
Published: March 2019

Summary
Purpose To examine the efficacy and safety of triple therapy with eribulin, trastuzumab, and pertuzumab in patients with HER2-positive metastatic breast cancer (MBC) who never received any prior therapy in the first-line metastatic/advanced setting. Methods Eribulin 1.4 mg/m2 (days 1 and 8), trastuzumab 8 mg/kg over 90 min and 6 mg/kg over 30 min, and pertuzumab 840 mg/body over 60 min and 420 mg/body over 30 min were administered intravenously in 21-day cycles. Results 25 women (median age, 57 years [range, 41–75 years]) received a median of 10 cycles (range, 0–34 cycles); 24 had performance status (PS) 0, 1 PS 1, 8 stage IV breast cancer, and 17 recurrence. Lung and liver metastases occurred in 9 and 9 patients, respectively. Median time to treatment failure with eribulin was 9.1 months (95% confidence interval [CI], 4.3–13.9 months), and median progression-free survival was 23.1 months (95% CI, 14.4–31.8 months). The overall response rate (complete response [CR] + partial response [PR]) was 80.0% (95% CI, 59.3–93.2%), and the clinical benefit rate (CR + PR + stable disease ≥24 weeks) was 84.0% (95% CI, 63.9–95.5%). The most common treatment-emergent adverse events (TEAEs) were alopecia (92.0%), fatigue (68.0%), and sensory peripheral neuropathy (60.0%). Grade 3/4 TEAEs occurred in 11 patients (44.0%). The only grade 4 TEAE was neutrophil count decreased (16.0%). Neither grade 4 peripheral neuropathy nor febrile neutropenia occurred. Conclusions ETP therapy showed acceptable efficacy and safety and is a potential first-line therapy for patients with HER2-positive MBC.
The socialization of attitudes about sex and their role in adolescent pornography use
Authors: Hardy Sam A. , Hurst Jeffrey L. , Price Joseph , Denton Melinda L. 
Published: March 2019

AbstractIntroductionThis study examines the socialization of conservative attitudes about sex and pornography use in later adolescence. We tested a socialization model whereby we anticipated that parent conservative sex attitudes would more strongly predict teen conservative sex attitudes when more frequent and higher quality parent‐teen communication was present. We further hypothesized that teen conservative sex attitudes would mediate relations between parent conservative sex attitudes and teen pornography use over time.MethodsThe data come from three waves of the National Survey of Youth and Religion (N = 3290; ages 13 through 18; M age = 15.5).ResultsPath analyses found that teen sex attitudes mediated the negative link between parent sex attitudes and subsequent teen pornography use, but frequency and quality of parent‐teen communication extensiveness (operationalized as frequency) and quality (operationalized as comfort) did not moderate the association between parent and teen sex attitudes. However, communication extensiveness did moderate relations between parent sex attitudes and later teen pornography use. The model was largely consistent across teen gender.ConclusionsIn short, parent and teen conservative sex attitudes are developmentally linked and predictive of later teen pornography use, but the role of parent‐teen communication and teen gender are complex and in need of further research.
Ranking the Attributes of Effective Disaster Responders and Leaders
Authors: King Richard V. , Larkin Gregory Luke , Klein Kelly R. , Fowler Raymond L. , Downs Dana L. , North Carol S. 
Published: March 2019

ABSTRACTObjectiveTo investigate the relative importance of 10 attributes identified in prior studies as essential for effective disaster medical responders and leaders.MethodsEmergency and disaster medical response personnel (N=220) ranked 10 categories of disaster worker attributes in order of their importance in contributing to the effectiveness of disaster responders and leaders.ResultsAttributes of disaster medical leaders and responders were rank ordered, and the rankings differed for leaders and responders. For leaders, problem-solving/decision-making and communication skills were the highest ranked, whereas teamwork/interpersonal skills and calm/cool were the highest ranked for responders.ConclusionsThe 10 previously identified attributes of effective disaster medical responders and leaders include personal characteristics and general skills in addition to knowledge of incident command and disaster medicine. The differences in rank orders of attributes for leaders and responders suggest that when applying these attributes in personnel recruitment, selection, and training, the proper emphasis and priority given to each attribute may vary by role. (Disaster Med Public Health Preparedness. 2019;13:700–703)
The earliest fossil record of true crickets belonging to the Baissogryllidae (Insecta, Orthoptera, Grylloidea)
Authors: Wang H. , Fang Y. N. , Fang Y. , Jarzembowski E. A. , Wang B. , Zhang H. C. 
Published: March 2019

AbstractBaissogryllidae is an extinct family of the insect superfamily Grylloidea, previously known from Late Jurassic – Early Cretaceous time. A new genus and species, Sinagryllus xinjiangensis gen. et sp. nov., is described here based on a well-preserved forewing from the Lower Jurassic Sangonghe Formation of Xinjiang, northwestern China. It can be attributed to Baissogryllidae based on the combination of the following characteristics: a true mirror in the male tegminal stridulatory apparatus; and a distinct widening of the area between CuA2, lateral part of the diagonal vein, and proximal part of the proximal branch of MP+CuA1. This find represents not only the earliest record of Baissogryllidae, but also the first fossil wing of Grylloidea reported from China.
Assessing callous-unemotional traits: development of a brief, reliable measure in a large and diverse sample of preadolescent youth
Authors: Hawes Samuel W. , Waller Rebecca , Thompson Wesley K. , Hyde Luke W. , Byrd Amy L. , Burt S. Alexandra , Klump Kelly L. , Gonzalez Raul 
Published: March 2019

AbstractBackgroundCallous-unemotional (CU) traits are critical to developmental, diagnostic, and clinical models of antisocial behaviors (AB). However, assessments of CU traits within large-scale longitudinal and neurobiologically focused investigations remain remarkably sparse. We sought to develop a brief measure of CU traits using items from widely administered instruments that could be linked to neuroimaging, genetic, and environmental data within already existing datasets and future studies.MethodsData came from a large and diverse sample (n= 4525) of youth (ages~9–11) taking part in the Adolescent Brain and Cognitive Development (ABCD) Study. Moderated nonlinear factor analysis was used to assess measurement invariance across sex, race, and age. We explored whether CU traits were distinct from other indicators of AB, investigated unique links with theoretically-relevant outcomes, and replicated findings in an independent sample.ResultsThe brief CU traits measure demonstrated strong psychometric properties and evidence of measurement invariance across sex, race, and age. On average, boys endorsed higher levels of CU traits than girls and CU traits were related to, yet distinguishable from other indicators of AB. The CU traits construct also exhibited expected associations with theoretically important outcomes. Study findings were also replicated across an independent sample of youth.ConclusionsIn a large, multi-site study, a brief measure of CU traits can be measured distinctly from other dimensions of AB. This measure provides the scientific community with a method to assess CU traits in the ABCD sample, as well as in other studies that may benefit from a brief assessment of CU.
Who Owns the Past? Turkey's Role in the Loss and Repatriation of Antiquities
Authors: Price Kathleen 
Published: March 2019

“Every flower is beautiful in its own garden. Every antiquity is beautiful in its own country. “ Sign in Ephesus Museum lobby, quoted in Lonely Planet Turkey (11th ed.) at 60.“History is beautiful where it belongs.”—OzgenAcar[Acar Erghan], imprinted on posters in Turkish libraries, classrooms, public buildings and shops and quoted in S. Waxman, Loot at 151; see also S. Waxman, Chasing the Lydian Hoard, Smithsonian.com, November 14, 2008.
Comparative Law and the Ad Hoc Tribunals: The Dangers of a Narrow Inquiry†
Authors: Borda Aldo Zammit 
Published: March 2019

AbstractThis article focuses on the distinctions that the ad hoc Tribunals have drawn between the comparative law method and the review of evidence for clarifying customary international law and general principles of law. It outlines the dangers in the readiness of some international judges to accept narrow inquiries, which at best attach special weight and at worst restrict the scope of inquiry to a single, specific legal system. The readiness of some international judges to simply elevate legal rules and concepts with which they are familiar from their own legal education and practice to the level of universal truths may imply a failure to understand the other legal traditions on offer. The article concludes by showing that, unless the dangers inherent in the readiness to accept narrow inquiries are clearly emphasized, the achievement of an international criminal justice that is truly tolerant of plurality is a long way off.
Islamic Banking in Malaysia†
Authors: Kunhibava Sherin 
Published: March 2019

AbstractIslamic banking is the conduct of banking according to Shariah or Islamic law. Statistically Islamic banking has had phenomenal growth, according to the Asian Banker Research Group, the world's 100 largest Islamic banks have set an annual asset growth rate of 26.7% and the global Islamic finance industry is experiencing an average growth of 15-20% annually1. Recently the Prime Minister of Malaysia commented that Malaysia has been maintaining its leadership in Islamic banking and finance for over three decades2. As an International leader in Islamic banking, it would be interesting to explore the development of Islamic banking in Malaysia. This will be the objective of this paper. This paper will focus on the historical development of Islamic banking in Malaysia, from the creation of the Haj Pilgrim's Fund Board in the 1960s to the current Islamic banking scene of 17 local Islamic banks and five International Islamic banks in operation. This paper will also explore the unique regulatory and governance framework of Islamic banking in Malaysia, by touching on the Islamic banking Act 1983, the Central Bank of Malaysia Act 2009, the Banking and Financial Institutions Act 1989 and the Shariah Governance Framework introduced in 2011 by the Central Bank of Malaysia. This paper will also briefly introduce how Islamic banking works.
Scenes from a Ramallah Law School
Authors: Shalakany Amr 
Published: March 2019

The following is not by way of apology, I just want to set the record straight. Diaries offer a view from somewhere - a perspective that is usually skewed, partial and incomplete. They are subjective reflections on a particularly situated experience. So let me begin from the beginning:I moved to Palestine early in September 2000. Two weeks later, the Intifada broke out. I had come to Palestine after finishing my PhD in the U.S. and working as a corporate lawyer in London. I had gone there with some vague urge “to be useful” - and if I thought being useful in Palestine meant saying farewell to middle-class life, I was soon proven wrong. For over a year I was teaching at Birzeit University and working as a legal adviser with the PLO Negotiations Support Unit. My interactions were mostly with middle-class Palestinians, sometimes the post-Oslo elite, often foreigners, seldom with the poor living in refugee camps. I lived in Al-Tireh, an upper-middle-class neighborhood in Ramallah. I had access to a car with yellow license-plates. Yellow was a very important color there. It meant I could drive my car anywhere I wanted, to Jerusalem and beyond - unlike most Palestinians, who had green license plates and, hence, could not drive outside the cantons created by the Oslo Accords. I had a foreign passport, which meant I could leave the Occupied Territories whenever I wanted to through Tel Aviv airport – again, unlike most Palestinians, who could not use the airport without first applying for a security permit.
The Archaeology of Land Law: Excavating Law in the West Bank
Authors: Orpett Natalie 
Published: March 2019

Land law in the West Bank is a mess of multi-layered legal regimes representing the complicated political history of the region. From this confusion flow some of the most contentious issues in the Israeli-Palestinian conflict today, such as the legitimacy of settlements and the legality of the security barrier. Whether one's concerns regarding the “Question of Palestine” are humanitarian or political, one fact is clear: the legal muddle of land law must be addressed.But addressing the law first requires that we understand what that law is. This paper is not an investigation of the relative legitimacy under domestic or international law of each of the innumerable changes that were made to land law over the course of multiple legal regimes. Rather, it attempts to develop a purely descriptive answer to the seemingly straightforward question: what is the state of land law? To do this, I reconstruct the law of land as much as possible, from the still-operative, sedimentary layers of Ottoman, British, Jordanian, Israeli, Palestinian and international law. In compiling this information, I hope to contribute to the efforts to fully understand where we are, so we can honestly assess where we may go from here.
Welcome Comments
Authors: Raleigh Juan Carlos Valle 
Published: March 2019

“There cannot be a mantle of oblivion. No society can start a new stage on an ethical claudication like” – Raúl AlfonsínIt is a matter of pride for the Argentine Foreign Affairs Ministry and especially for the National Foreign Service under my direction, to give you a very warm welcome and to be able to host the 33rdCourse on International Law and Legal Information organized by the prestigious International Association of Law Libraries (IALL).
A false promise? Regulating land-grabbing and the post-colonial state
Authors: Tzouvala Ntina 
Published: March 2019

AbstractSince 2008, a global ‘land rush’ has been unfolding and so have efforts by international, national and regional actors to position themselves as the principal authorities in the determination of appropriate usages of land. This article examines three of the most influential ‘soft law’ instruments: the Principles for Responsible Agricultural Investment; the Principles for Responsible Investment in Agriculture and Food Systems and; the Voluntary Guidelines on the Responsible Governance of Tenure. Despite their substantive differences, all three documents share a specific form of state-centrism. They imagine the host state of such large-scale investments as internally unitary and externally independent and entrust it with the bulk of responsibilities regarding the management of land investments. However, I argue that this particular form of state-centrism obscures the legal and administrative realities of the post-colonial state that is often legally bifurcated and subject to pervasive forms of international authority. Rather, an appreciation of the multitude of actors who claim jurisdiction over the lands of the South enables a better understanding of the legal mechanics of land-grabbing. Sierra Leone, which has been positioned as a ‘poster child’ for the implementation of such ‘soft law’ instruments, serves as the focal point of this jurisdictional approach to land-grabbing. In this context, the promise of ‘soft law’ instruments to make the post-colonial state the guarantor of universally beneficial large-scale land acquisitions is shown to be a false one.
Prevalence and genotypes of anal human papillomavirus infection among HIV-positivevs. HIV-negative men in Taizhou, China
Authors: Liu X. , Lin H. , Chen X. , Shen W. , Ye X. , Lin Y. , Lin Z. , Zhou S. , Gao M. , Ding Y. , He N. 
Published: March 2019

AbstractThis study aims to investigate the prevalence and genotype distribution of anal human papillomavirus (HPV) infection among men with different sexual orientations with or without human immunodeficiency virus (HIV) in China. A cross-sectional study was conducted during 2016–2017 in Taizhou City, Zhejiang Province. Convenient sampling was used to recruit male participants from HIV voluntary counselling and testing clinics and Center for Disease Control and Prevention. A face-to-face questionnaire interview was administered and an anal-canal swab was collected for HPV genotyping. A total of 160 HIV-positive and 113 HIV-negative men participated in the study. The prevalence of any type HPV was 30.6% for heterosexual men, 74.1% for homosexual and 63.6% for bisexual men among HIV-positive participants, while the prevalence was 8.3%, 29.2% and 23.8% respectively among HIV-negatives. The most prevalent genotypes were HPV-58 (16.9%), HPV-6 (15.6%) and HPV-11 (15.0%) among HIV-positive men, and were HPV-16 (4.4%), HPV-52 (4.4%) and HPV-6 (3.5%) among HIV-negative men. Having ever had haemorrhoids and having ever seen blood on tissue after defaecation was associated with HPV infection. One-fourth of the HPV infections in this study population can be covered by the quadrivalent vaccine in market. The highly prevalent anal HPV infection among men especially HIV-infected men calls for close observation and further investigation for anal cancer prevention.
Antimicrobial resistance patterns of bacteria isolated from dogs with otitis
Authors: Bourély C. , Cazeau G. , Jarrige N. , Leblond A. , Madec J.Y. , Haenni M. , Gay E. 
Published: March 2019

AbstractAntimicrobial-resistant bacteria in dogs can be transmitted to humans and close contact between dogs and people might foster dissemination of resistance determinants. The aim of our study was to describe the antimicrobial resistance (AMR) pattern of the major causative agents of canine otitis – one of the most common diseases in dogs – isolated in France. Data collected between 2012 and 2016 by the French national surveillance network for AMR, referred to as RESAPATH, were analysed. Resistance trends were investigated using non-linear analysis (generalised additive models). A total of 7021 antibiograms were analysed. The four major causative agents of canine otitis in France were coagulase-positive staphylococci,Pseudomonas aeruginosa,Proteus mirabilisand streptococci. Since 2013, resistance to fluoroquinolones has been on the decrease in bothP. aeruginosaandStaphylococcus pseudintermediusisolates. ForP. aeruginosa, 19.4% of isolates were resistant to both enrofloxacin and gentamicin. The levels of multidrug resistance (acquired resistance to at least one antibiotic in three or more antibiotic classes) ranged between 11.9% forP. mirabilisand 16.0% forS. pseudintermedius.These results are essential to guide prudent use of antibiotics in veterinary medicine. They will also help in designing efficient control strategies and in measuring their effectiveness.
Associations between antibiotic prescriptions and recurrent urinary tract infections in female college students
Authors: Rich S. N. , Klann E. M. , Almond C. R. , Larkin E. M. , Nicolette G. , Ball J. D. 
Published: March 2019

AbstractUrinary tract infections (UTIs) are common among college-aged women and often recur. Some antibiotics recommended to treat UTIs trigger dysbiosis of intestinal and vaginal microbiomes – where uropathogens originate, though few studies have investigated associations between these therapies with recurrent infections. We retrospectively analysed the electronic medical records of 6651 college-aged women diagnosed with a UTI at a US university student health centre between 2006 and 2014. Women were followed for 6 months for incidence of a recurrent infection. In a secondary analysis, associations in women whose experienced UTI recurrence within 2 weeks were also considered for potential infection relapse. Logistic regression was used to assess associations between infection recurrence or relapse and antibiotics prescribed, in addition to baseline patient characteristics including age, race/ethnicity, region of origin, year of encounter, presence of symptomology, pyelonephritis, vaginal coinfection and birth control consultation. There were 1051 instances of infection recurrence among the 6620 patients, indicating a prevalence of 16%. In the analysis of patient characteristics, Asian women were statistically more likely to experience infection recurrence whereas African American were less likely. No significant associations were identified between the antibiotic administered at the initial infection and the risk of infection recurrence after multivariable adjustment. Treatment with trimethoprim-sulphamethoxazole and being born outside of the USA were significantly associated with increased odds of infection relapse in the multivariate analysis. The results of the analyses suggest that treatment with trimethoprim-sulphamethoxazole may lead to an increased risk of UTI relapse, warranting further study.
School sessions are correlated with seasonal outbreaks of medically attended respiratory infections: electronic health record time series analysis, Wisconsin 2004–2011
Authors: Temte J. L. , Meiman J. G. , Gangnon R. E. 
Published: March 2019

AbstractIncreased social contact within school settings is thought to be an important factor in seasonal outbreaks of acute respiratory infection (ARI). To better understand the degree of impact, we analysed electronic health records and compared risks of respiratory infections within communities while schools were in session and out-of-session. A time series analysis of weekly respiratory infection diagnoses from 28 family medicine clinics in Wisconsin showed that people under the age of 65 experienced an increased risk of ARI when schools were in session. For children aged 5–17 years, the risk ratio for the first week of a school session was 1.12 (95% confidence interval (CI) 0.93–1.34), the second week of a session was 1.39 (95% CI 1.15–1.68) and more than 2 weeks into a session was 1.43 (95% CI 1.20–1.71). Less significant increased risk ratios were also observed in young children (0–4 years) and adults (18–64 years). These results were obtained after modelling for baseline seasonal variations in disease prevalence and controlling for short-term changes in ambient temperature and relative humidity. Understanding the mechanisms of seasonality make it easier to predict outbreaks and launch timely public health interventions.