bluuebunny/crossref_metadata_2025_split huggingface dataset:
Binding Affinity Regression Models from Repeats Mutation in Polyglutamine Disease
Authors: Asha P R , Vijaya M S 
Published: March 2018

AbstractDiagnosing and curing neurodegenarative disorder such as spinocerebellar ataxia is complicated when there is differences in formation of protein sequences and structures. Affinity prediction plays vital role to identify drugs for various genetic disorders. Spinocerebellar ataxia occurs but mainly it occurs due to polyglutamine repeats. This research work aims in predicting the affinity of spinocerebellar ataxia from the protein complexes by extracting the well-defined descriptors. Regression models are built to predict the affinity through machine learning techniques coded in python using the Scikit-Learn framework. Energy complexes and protein sequence descriptors are defined and extracted from the complex and sequences. Results show that the SVR is found to predict the affinity with high accuracy of 98% for spinocerebellar ataxia. This paper also deliberates the results of statistical learning carried out with the same set of complexes with various regression techniques.
Topographic diversity of structural connectivity in schizophrenia
Authors: Ruan Hongtao , Luo Qiang , Palaniyappan Lena , Huang Chu-Chung , Zac Lo Chun-Yi , Liu Mu-En , Yang Albert C , Tsai Shih-Jen , Lin Ching-Po , Feng Jianfeng 
Published: March 2018

AbstractThe neurobiological heterogeneity of schizophrenia is widely accepted, but it is unclear how mechanistic differences converge to produce the observed phenotype. Establishing a pathophysiological model that accounts for both heterogeneity and phenotypic similarity is essential to inform stratified treatment approaches. In this cross-sectional diffusion tensor imaging (DTI) study, we recruited 77 healthy controls (HC), and 71 patients with DSM-IV diagnosis of schizophrenia (SCZ), and reconstructed the structural connectivity of 90 brain regions covering entire cerebral cortex. We first confirmed the heterogeneity in structural connectivity by showing a reduced inter-individual similarity in SCZ compared with HC. Moreover, we found it was not possible to cluster patients into subgroups with shared patterns of dysconnectivity, indicating a high degree of mechanistic divergence in schizophrenia. Instead of the strength of connectivity between any particular brain regions, we investigated the diversity (or statistically, the variance) of the topographic distribution of the strength was reduced. HC had higher topographic diversity in whole brain structural connectivity compared to the patient group(P = 2 × 10−6, T = 4.96, Cohen′S d = 0.87). In 62 of the 90 brain regions, the topographic diversity was significantly reduced in patients compared to controls after FDR correction (<0.05). When topographic diversity was used as a discriminant feature for classification between patients and controls, we significantly (P = 4.29 × 10−24) improved the classification accuracy to 79.6% (sensitivity 78.3%, specificity 81.3%). This finding suggests highly individualized pattern of structural dysconnectivity underlying the heterogeneity of schizophrenia converges to a convergent common pathway as reduced topographic diversity for the clinical construct of the disease.
Identifying G protein-coupled receptor dimers from crystal packings
Authors: Stenkamp Ronald E. 
Published: March 2018

AbstractDimers of G protein-coupled receptors are believed to be important for signaling with their associated G proteins. Low resolution electron microscopy shows rhodopsin dimers in native retinal membranes, and CXCR4 dimers are found in several different crystal structures. Evidence for dimers of other GPCRs is more indirect. An alternative to computational modeling studies is to search for parallel dimers in the packing environments of the reported crystal structures of GPCRs. Two major structural types of GPCR dimers exist (as predicted by others), but there is considerable structural variation within each cluster. The different structural variants described here might reflect different functional properties and should provide a range of model structures for computational and experimental examination.SynopsisAnalysis of intermolecular interactions in G protein-coupled receptor crystal structures shows two major types of dimers.
Covert spatial selection in primate basal ganglia
Authors: Arcizet Fabrice , Krauzlis Richard J. 
Published: March 2018

AbstractThe basal ganglia are important for action selection. They are also implicated in perceptual and cognitive functions that seem far removed from motor control. Here, we tested whether the role of the basal ganglia in selection extends to non-motor aspects of behavior by recording neuronal activity in the caudate nucleus while animals performed a covert spatial attention task. We found that caudate neurons strongly select the spatial location of the relevant stimulus throughout the task even in the absence of any overt action. This spatially selective activity was dependent on task and visual conditions, and could be dissociated from goal-directed actions. Caudate activity was also sufficient to correctly identify every epoch in the covert attention task. These results provide a novel perspective on mechanisms of attention by demonstrating that the basal ganglia are involved in spatial selection and tracking of behavioral states even in the absence of overt orienting movements.
Inter- and intra-specific genomic divergence inDrosophila montanashows evidence for cold adaptation
Authors: Parker D. J. , Wiberg R. A. W. , Trivedi U. , Tyukmaeva V. I. , Gharbi K. , Butlin R. K. , Hoikkala A. , Kankare M. , Ritchie M. G. 
Published: March 2018

AbstractThe genomes of species that are ecological specialists will likely contain signatures of genomic adaptation to their niche. However, distinguishing genes related to their ecological specialism from other sources of selection and more random changes is a challenge. Here we describe the genome ofDrosophila montana, the most extremely cold-adapted Drosophila species. We describe the genome, which is similar in size and gene content to most Drosophila species. We look for evidence of accelerated divergence from a previously sequenced relative, and do not find strong evidence for divergent selection on coding sequence variation. We use branch tests to identify genes showing accelerated divergence in contrasts between cold- and warm adapted species and identify about 250 genes that show differences, possibly driven by a lower synonymous substitution rate in cold-adapted species. Divergent genes are involved in a variety of functions, including cuticular and olfactory processes. We also re-sequenced three populations ofD. montanarepresenting its ecological and geographic range. Outlier loci were more likely to be found on the X chromosome and there was a greater than expected overlap between population outliers and those genes implicated in cold adaptation between Drosophila species, implying some continuity of selective process at these different evolutionary scales.
Chronic health and lifestyle problems for people diagnosed with autism in a student-led clinic
Authors: Tolchard Barry , Stuhlmiller Cynthia 
Published: March 2018

Purpose
People with autism spectrum disorder (ASD) are at greater risk of developing chronic health and risky lifestyle problems. This is exaggerated further for people living in rural settings and from cultural backgrounds traditionally underserved by healthcare services. The purpose of this paper is to describe an evaluation of health and behavioural lifestyle outcomes of people diagnosed with ASD in a student-led clinic in rural/regional Australia.

Design/methodology/approach
Routine clinical outcomes and lifestyle measures were routinely collected at a primary acre student-led Clinic in rural/regional Australia. Participants were all attending the clinic who provided consent for their routine date to be reported. Participants ranged in age from new born to 100 years and were representative of the local community.

Findings
The results indicate there is an increased risk for people with ASD developing chronic conditions compared to those without a diagnosis. This also resulted in higher body mass index and blood sugar levels linked to diabetes and hypertension. Mental health problems were common in people diagnosed with ASD especially anxiety disorders. Smoking was problematic for people with ASD but mainly in non-Aboriginal and Torres Strait Islanders. Alcohol use was not an increase risk in ASD.

Originality/value
Little is reported on the health and lifestyle experiences of people with ASD in rural/regional settings, especially from Aboriginal and Torres Strait Islander communities. This paper gives an initial insight to the presentation of chronic conditions and harmful lifestyle choices. Possible insights into adapting or modifying care for people with ASD in rural/regional Australia are given.
The role of directors: unravelling the effects of boards on corporate outcomes
Authors: Bravo Francisco , Reguera-Alvarado Nuria , del Pilar Pérez María 
Published: March 2018

PurposeThe purpose of this paper is to analyse whether the theoretical relationship between the board composition and the cost of capital (CC) is mediated by risk disclosure (RD) practices.Design/methodology/approachPartial least squares techniques are used, and a sample of all the companies belonging to manufacturing industry listed on Standard and Poor’s 500 for the year 2009 is studied. In relation to board composition, several recommendations issued by US governance codes are considered: board independence, board size, CEO duality, gender diversity, ethnic diversity, and financial expertise. Content analysis techniques are employed to measure RDs.FindingsThe results show that boards that follow governance codes recommendations lead to a reduction in the CC through the disclosure of information on risks.Research limitations/implicationsThese results provide encouraging opportunities for future research about the real role of the board of directors and suggest the need for the analysis of the participation of directors in firm strategy to better understand the effect of boards on the corporate outcome.Practical implicationsThis evidence must help regulators and owners to set up adequate corporate governance mechanisms regarding the composition of boards. This evidence also presents direct implications for managers, who can better understand the value-relevance of RDs.Originality/valueThis paper provides new insight into the literature, which highlights that the effect of boards of directors on firm outcomes must be mediated by the involvement of boards in specific strategies.
Readiness assessment of leagility supply chain based on fuzzy cognitive maps and interpretive structural modeling: a case study
Authors: Kalantari Taher , Khoshalhan Farid 
Published: March 2018

Purpose
The evaluation of readiness provides insight into the readiness of its individual components for successful accomplishment of tasks. This study aims to evaluate readiness in leagility of supply chains based on the design and analysis of fuzzy cognitive maps (FCM) and interpretive structural modeling (ISM).

Design/methodology/approach
On the basis of the purpose of this study, data are gathered via the Delphi method. Moreover, FCM and ISM are also used to evaluate readiness.

Findings
Findings initially demonstrate a categorization of factors influencing leagility into static and dynamic variables according to the degree of their influence derived from the resultant behavior of FCM and ISM. It is also found that evaluating readiness in leagility of supply chains with ISM and FCM was done with respect to the type and role of the study variables, which were determined within the minimum and maximum ranges of 20 to 100 per cent, respectively.

Originality/value
The evaluation of the readiness using the FCM and ISM is proved to be more efficient than other classical methods. Experimental results of the study contribute to improve readiness of leagility of supply chain as well as develop functional areas of business.
The cooperation-competition interplay in the ICT industry
Authors: Leite Emilene , Pahlberg Cecilia , Åberg Susanne 
Published: March 2018

Purpose
Building on a business network perspective, the paper addresses the following question: Why do firms move between cooperation and competition in the context of high-tech industry? Hence, the purpose of this study is to contribute to the understanding of the complex cooperation–competition interplay between actors in a business network.

Design/methodology/approach
A single case study within the information and communication technology industry is undertaken and illustrates the cooperation–competition interplay in projects of technology.

Findings
The authors discuss the implications of interdependence on relationship dynamics. The main argument is that business relationships survive despite periods of competition if interdependence is high. Thus, firms move between a state of cooperation and a state of competition within business relationships, rather than ending the relationships when starting to compete.

Practical implications
This study suggests that managers need to pay attention to how different degrees of interdependence lead firms to be embedded in cooperative or competitive forms of relationships.

Originality/value
The paper contributes to the ongoing debate about cooperation, competition and coopetition within international business and industrial marketing literature. An interesting aspect in the paper is the cooperation–competition interplay, which is associated with positioning. A centrally positioned actor will choose who to bring into the partnership, with positioning concomitantly changing from project to project. The willingness of being a central actor, i.e. a project leader, places traditional buyer–supplier partners in competition. Thus, cooperation and/or competition becomes contextual.
Do brand communities benefit objectively under-performing products?
Authors: Thompson Scott A. , Kaikati Andrew M. , Loveland James M. 
Published: March 2018

Purpose
The purpose of this study is to investigate the effect of brand community participation on new product adoption when the new product is the one which clearly under-performed compared to industry standards.

Design/methodology/approach
The data on participation behavior, membership duration and adoption behavior of 5,893 members of three different online communities (two brand forums, one general product forum) were gathered and assessed using a Cox PH model.

Findings
Results show that higher participation in a brand community leads to a greater likelihood of adopting objectively under-performing products, while also reducing the likelihood of purchasing rivals’ products. This occurs despite the higher levels of product knowledge possessed by these consumers. The findings also identify a key limiting condition for oppositional loyalty, that it is driven by membership duration, rather than by active participation in the brand community.

Originality/value
Prior research on the impact of brand community participation on product adoption has tended to focus on the adoption of products that are objectively superior to competing products. Unfortunately, only one product can be the performance leader in a given market at any time. Thus, managers do not know if brand communities are powerful enough to enhance the likelihood of adopting objectively under-performing products. This manuscript thus provides important insights for managers wishing to launch new products in categories where there are active brand communities.
The influence of collaborative competence and service innovation on manufacturers’ competitive advantage
Authors: Liu Feng-Hsu , Huang Tseng-Lung 
Published: March 2018

PurposeWhile service innovation is an important issue for manufacturers, relatively little research lends empirical support to the perspective that service innovation enhanced by collaborative competence may impact the competitive advantage of original equipment manufacturing (OEM) suppliers. This study aims to advance a service-dominant logic by empirically investigating the linkage between collaborative competence, service innovation and competitive advantage for OEM suppliers.Design/methodology/approachSurveys were completed by representatives of 142 Taiwanese OEM suppliers in the electronics industry.FindingsThe results of path analysis suggest that information competence and coordination competence have positive effects on both exploitative service innovation and explorative service innovation. There only appears to be a significant relationship between joint innovation competence and explorative service innovation. Furthermore, two-pronged service innovations contribute to a supplier’s internal and external competitive advantage.Originality/valueThe empirical findings have important research and practical implications that help elucidate the antecedents and outcomes of OEM suppliers’ service innovation.
A novel memetic algorithm with a deterministic parameter control for efficient berth scheduling at marine container terminals
Authors: Dulebenets Maxim A. 
Published: March 2018

Purpose
The volumes of international containerized trade substantially increased over the past years. In the meantime, marine container terminal (MCT) operators are facing congestion issues at their terminals because of the increasing number of large-size vessels, the lack of innovative technologies and advanced handling equipment and the inability of proper scheduling of the available resources. This study aims to propose a novel memetic algorithm with a deterministic parameter control to facilitate the berth scheduling at MCTs and minimize the total vessel service cost.

Design/methodology/approach
A local search heuristic, which is based on the first-come-first-served policy, is applied at the chromosomes and population initialization stage within the developed memetic algorithm (MA). The deterministic parameter control strategy is implemented for a custom mutation operator, which alters the mutation rate values based on the piecewise function throughout the evolution of the algorithm. Performance of the proposed MA is compared with that of the alternative solution algorithms widely used in the berth scheduling literature, including a MA that does not apply the deterministic parameter control strategy, typical evolutionary algorithm, simulated annealing and variable neighborhood search.

Findings
Results demonstrate that the developed MA with a deterministic parameter control can obtain superior berth schedules in terms of the total vessel service cost within a reasonable computational time. Furthermore, greater cost savings are observed for the cases with high demand and low berthing capacity at the terminal. A comprehensive analysis of the convergence patterns indicates that introduction of the custom mutation operator with a deterministic control for the mutation rate value would provide more efficient exploration and exploitation of the search space.

Research limitations/implications
This study does not account for uncertainty in vessel arrivals. Furthermore, potential changes in the vessel handling times owing to terminal disruptions are not captured.

Practical implications
The developed solution algorithm can serve as an efficient planning tool for MCT operators and assist with efficient berth scheduling for both discrete and continuous berthing layout cases.

Originality/value
The majority of studies on berth scheduling rely on the stochastic search algorithms without considering the specific problem properties and applying the guided search heuristics. Unlike canonical evolutionary algorithms, the developed algorithm uses a local search heuristic for the chromosomes and population initialization and adjusts the mutation rate values based on a deterministic parameter control strategy for more efficient exploration and exploitation of the search space.
An evaluation of mid-stream operation in Hong Kong
Authors: Lau Yui-yip , Ng Adolf K.Y. 
Published: March 2018

Purpose
Mid-stream operation has had a significant role in Hong Kong’s economic development since the 1960s. Prior to the building of container terminals in Hong Kong, cargo was mainly loaded onto and discharged from ocean-going vessels by mid-stream operations and then shipped to Europe and North America. This paper aims to reinforce mid-stream operation is considered a “must” in supporting the substantial growth of maritime industry and strengthening Hong Kong’s role as an entrepôt.

Design/methodology/approach
The authors undertake a historical review of the evolution of Hong Kong’s mid-stream operation over the past half-century and investigate the future of mid-stream operation in light of the Hong Kong Special Administrative Region government’s policy of allocating Public Cargo Working Areas through an open auction process. Semi-structured, in-depth interviews are also undertaken in this study.

Findings
The emergence of container terminals generated competition for cargo between container terminals and mid-stream operators. In addition, the Hong Kong Special Administrative Region government’s policy of allocating Public Cargo Working Areas to mid-stream operators through an open auction process intensified negative influences on the survival of the mid-stream operation sector.

Originality/value
To date, mid-stream operation has been abandoned nearly everywhere except in Hong Kong. Yet, Hong Kong’s container system has become the most advanced in the world. The authors explain how and why mid-stream operation still plays such a key role in Hong Kong and how to enhance its sustainability. The authors also discuss the academic and managerial implications of their findings.
Cold supply chain of longline tuna and transport choice
Authors: Yang Yi-Chih , Lin Han-Yu 
Published: March 2018

Purpose
The four purposes of this study are to understand the development and the current status of Taiwan’s far seas longline tuna fisheries through a review of the literature and interviews; to investigate the attitude of Taiwanese fishing vessel operators fishing in the Indian Ocean concerning the use of transportation under the influence of various factors; to analyze the relationship between changes in the transportation behavior of Taiwanese fishing vessel operators and various factors; and to provide suggestions to government and industry associations concerning the development of viable response strategies.

Design/methodology/approach
This paper uses methods including factor analysis and the analytic hierarchy process to analyze questionnaires collected from industry personnel and governmental personnel involved in the supply chain system of the longline tuna fishery in the Indian Ocean.

Findings
It is found that 16 assessment criteria in four major dimensions have major influence on the choice of cold chain transport. An assessment of all dimensions indicates that reefer ships are still the preferred means of transshipping frozen catch.

Originality/value
This paper seeks to investigate factors affecting choice of cold chain mode of transport from the perspective of Taiwanese companies operating longline tuna fishing vessels in the Indian Ocean, which are chiefly motivated by the need to reduce operating costs, and also looks at their choices of means of transport.