bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mixed intoxication by the synthetic opioid U‐47700 and the benzodiazepine flubromazepam with lethal outcome: Pharmacokinetic data
Authors: Koch Katharina , Auwärter Volker , Hermanns‐Clausen Maren , Wilde Maurice , Neukamm Merja A. 
Published: April 2018

AbstractNovel synthetic opioids and benzodiazepines are an emerging trend on the narcotic drugs market. We present a lethal case of U‐47700 and flubromazepam poisoning. A 24‐year‐old man suffered apnoea after the consumption of the synthetic opioid U‐47700 in combination with the benzodiazepine flubromazepam. After reanimation and hospital admission, hypoxic cerebral damage and severe brain oedema were stated. Six days after admission, mechanical ventilation was discontinued, and the patient died. Seven blood serum samples and one urine sample collected during the hospitalisation were analysed by liquid chromatography–tandem mass spectrometry. In the sample collected 42 minutes after admission, the concentrations of U‐47700 and flubromazepam were 370 and 830 ng/mL, respectively. Three days later, the concentrations of U‐47700 and flubromazepam dropped to 4.2 and 280 ng/mL, respectively. The resulting concentration‐time‐curves allowed calculating a U‐47700 elimination half‐life of approximately six hours and confirmed the previously reported flubromazepam elimination half‐life of around 100 hours. In the presented case, intoxication by the synthetic opioid U‐47700 with a contribution of flubromazepam can be assumed as the cause of death. The concentration‐time curves allow an estimation of the clinical course of similar cases. Flubromazepam may lead to prolonged central‐nervous depressant effects.
Outcome parameters associated with perceived helpfulness of family‐based treatment for adolescent eating disorders
Authors: Singh Simar , Accurso Erin C. , Hail Lisa , Goldschmidt Andrea B. , Le Grange Daniel 
Published: April 2018

AbstractObjectiveFamily‐based treatment (FBT) is an efficacious treatment for adolescent eating disorders, yet it is not routinely implemented in clinical practice. Given that consumers play a role in treatment selection, this study sought to examine families’ perspectives on FBT and remission markers associated with increased treatment satisfaction across families.MethodParticipants were 40 adolescents and 43 caregivers who received outpatient FBT. FBT helpfulness was assessed using a treatment follow‐up questionnaire, and eating disorder symptomatology was assessed using percent expected body weight (%EBW) and the eating disorder examination (EDE). Regression analyses were used to assess whether changes in symptoms from baseline to end‐of‐treatment (EOT) were significantly associated with helpfulness reports.ResultsOn average, patients and their parents perceived FBT as “quite helpful” and “extremely helpful,” respectively. Improvements in all EDE subscales, with the exception of restraint, were significantly associated with adolescent report of helpfulness (all p < .05); increase in %EBW was significantly associated with maternal report of helpfulness (p = .03). There were no significant findings for paternal report.DiscussionBoth patients and their parents perceived FBT as helpful, but patients seemed to prioritize cognitive improvements while mothers prioritized physical improvements in rating their satisfaction with FBT.
Material Measures of Electrocaloric Cooling Power in Perovskite Ferroelectrics
Authors: Weyland Florian , Perez‐Moyet Richard , Rossetti George A. , Novak Nikola 
Published: April 2018

AbstractMany ferroelectric materials that can serve as refrigerants in electrocaloric cooling devices have been identified. To compare them, material measures of cooling power are useful. The electrocaloric performance characteristics of ferroelectric materials are determined to a large degree by the nature of the paraelectric to ferroelectric phase change, which influences the magnitude of the electrocaloric effect and the variation with temperature of the thermal conductivity and heat capacity. Here, those properties are compared for three promising ferroelectric materials. The materials chosen for study have differing phase change characteristics ranging from first‐order to diffuse/relaxor‐like behavior, and include barium titanate and lead magnesium niobate—lead titanate single crystals and polycrystalline barium zirconate‐titanate ceramics. Using measured thermophysical property data, and a simple model based on the Newtonian cooling of a thin plate, the dependences of the material cooling power on the dimensionless temperature, characteristic distance, and holding time for heat transfer are determined. Relationships existing between material cooling power and the nature of the phase transition, thermophysical properties, and the electrocaloric behavior are illustrated. Although device‐level factors, such as thermal resistances at electrode interfaces are ignored, the results suggest a simple basis of comparison for electrocaloric materials.
Effects of ethanol combined with ascorbic acid and packaging on the inhibition of browning and microbial growth in fresh‐cut Chinese yam
Authors: Gao Jia , Zhu Yongqing , Luo Fangyao 
Published: April 2018

AbstractThe objective of this study was to investigate the effects of aqueous solutions of ethanol (25%, v/v) and ascorbic acid (AA, 1%, m/v) alone and in combination, along with modified atmosphere packaging (MAP) or vacuum packaging (VP), on the physicochemical properties and microbial quality of fresh‐cut Chinese yam slices during 4°C storage. The data showed that ethanol (25%, v/v) combined with AA (1%, m/v) and MAP treatment resulted in the lowest changes for headspace gas composition, color, electrical conductivity, overall visual quality, aerobic plate count population, and mold and yeast population in fresh‐cut Chinese yam over 21 days of 4°C cold storage, which was more effective at both inhibiting microbial growth and delaying browning than ethanol or AA alone or a commonly used sanitizer, sodium hypochlorite. The experiment on packaging demonstrated that samples treated with VP and 25% ethanol with 1% (m/v) AA dip can only preserve the sensory qualities of fresh‐cut Chinese yam slices up to 7 days at 4°C, but 25% (v/v) ethanol in conjunction with 1% (m/v) AA packed with MAP had antibrowning potential and maintained the quality of fresh‐cut Chinese yam slices up to 14 days when stored at 4°C.
CFAI‐Plus: Adding cognitive frailty as a new domain to the comprehensive frailty assessment instrument
Authors: De Roeck Ellen Elisa , Dury Sarah , De Witte Nico , De Donder Liesbeth , Bjerke Maria , De Deyn Peter Paul , Engelborghs Sebastiaan , Dierckx Eva 
Published: April 2018

ObjectivesCognitive frailty is characterized by the presence of cognitive impairment in exclusion of dementia. In line with other frailty domains, cognitive frailty is associated with negative outcomes. The Comprehensive Frailty Assessment Instrument (CFAI) measures 4 domains of frailty, namely physical, psychological, social, and environmental frailty. The absence of cognitive frailty is a limitation.MethodAn expert panel selected 6 questions from the Informant Questionnaire on Cognitive Decline that were, together with the CFAI and the Montreal cognitive assessment administered to 355 older community dwelling adults (mean age = 77).ResultsAfter multivariate analysis, 2 questions were excluded. All the questions from the original CFAI were implemented in a principal component analysis together with the 4 cognitive questions, showing that the 4 cognitive questions all load on 1 factor, representing the cognitive domain of frailty. By adding the cognitive domain to the CFAI, the reliability of the adapted CFAI (CFAI‐Plus), remains good (Cronbach's alpha: .767).ConclusionsThis study showed that cognitive frailty can be added to the CFAI without affecting its good psychometric properties. In the future, the CFAI‐Plus needs to be validated in an independent cohort, and the interaction with the other frailty domains needs to be studied.
Efficacy of a clinical pathway for patients with thyroid cancer
Authors: Kwon Hyungju , Lee Joon‐Hyop , Woo Joohyun , Lim Woosung , Moon Byung‐In , Paik Nam Sun 
Published: April 2018

AbstractBackgroundClinical pathways have been proposed as a way to improve organizational efficiency and maximize patient outcomes. However, little is known as to whether a clinical pathway is effective for thyroid cancer.MethodsThe study subjects included 216 patients who were managed after clinical pathway implementation and 145 control patients. Length of stay, cost per patient, and nurses' satisfaction were compared in the 2 groups.ResultsMean length of stay was 0.8 days shorter in the clinical pathway group than in the control group (2.9 vs 3.7 days; P = .023). Cost per patient was also lower in the clinical pathway than in the control group (USD $3953.00 vs USD $4636.00; P < .001). Nurses' overall satisfaction scores improved from 71.6% before to 82.5% after implementation of the clinical pathway and their job characteristics scores increased from 61.1% to 75.0%.ConclusionImplementation of a clinical pathway for thyroid cancer can improve nurses' satisfaction with reduction of hospital stay and costs.
Use of the 50‐g glucose challenge test to predict excess delivery weight
Authors: Beksac M. Sinan , Tanacan Atakan , Hakli Duygu A. , Ozyuncu Ozgur 
Published: April 2018

AbstractObjectiveTo identify a cut‐off value for the 50‐g glucose challenge test (GCT) that predicts excess delivery weight.MethodsA retrospective study was conducted among pregnant women who undertook a 50‐g GCT at Hacettepe University Hospital, Ankara, Turkey, between January 1, 2000, and December 31, 2016. Patients with singleton pregnancies who delivered live neonates after 28 weeks of pregnancy were included. Patients were classified according to their 50‐g GCT values into group 1 (<7.770 mmol/L); group 2 (7.770 to <8.880 mmol/L, group 3 (8.880–9.990 mmol/L); or group 4 (>9.990 mmol/L). Classification and regression tree data mining was performed to identify the 50‐g GCT cut‐off value corresponding to a substantial increase in delivery weight.,ResultsMedian delivery weight were 3100 g in group 1 (n=352), 3200 g in group 2 (n=165), 3720 g in group 3 (n=47), and 3865 g in group 4 (n=20). Gravidity, 50‐g GCT value, and pregnancy duration at delivery explained 30.6% of the observed variance in delivery weight. The cut‐off required for maternal blood glucose level to predict excessive delivery weight was 8.741 mmol/L.ConclusionThe 50‐g GCT can be used to identify women at risk of delivering offspring with excessive delivery weight.
RELATIONSHIPS BETWEEN COMMON GRAPHICAL REPRESENTATIONS USED IN SYSTEM ENGINEERING
Authors: Long James E. 
Published: April 2018

ABSTRACTMost system engineers today use graphical representations of a system to communicate its functional and data requirements. The most commonly used representations are the Function Flow Block Diagram (FFBD), Data Flow Diagram (DFD), N2 Chart, IDEF0 Diagram, and Behavior Diagram (BD). This paper discusses the characteristics of each and shows how they are related.
The involvement of Kav001 in inhibition of LPS/P. gingivalis‐induced
Authors: Tang Xiaoren , Alasiri Mansour , Bamashmous Abdullah , Aljahdali Bushra , Cao Feng , Dibart Serge , Salih Erdjan 
Published: April 2018

AbstractTNF‐a is an important cytokine mediator of inflammation which suggests that inhibition of TNF activity may provide potential for clinical application. Recent data indicated that treatment of both human and mouse cells with Kavain significantly modulates P. gingivalis‐ and LPS‐induced TNF‐α expression. In order to obtain a selective analog with optimized biological activity and structural physico‐chemical properties of Kavain, Kavain analogs were designed and synthesized and found one Kavain analogue (named Kav001) that is similar to Kavain but soluble and does not induce a significant toxicity. Both studies in vitro and in vivo treatment by Kav001 showed stronger biological function as compared to Kavain. Furthermore, most mouse bone marrow macrophages up‐regulated Bcl‐6 while down‐regulating LITAF expression after treatment with Kav001 for 36 h. Consequently, this led to an extension of macrophage pseudopods due to its immune response to P.g. infection/LPS stimulation.
Cardiomyogenic differentiation of human adipose‐derived mesenchymal stem cells transduced with Tbx20‐encoding lentiviral vectors
Authors: Neshati Vajiheh , Mollazadeh Samaneh , Fazly Bazzaz Bibi Sedigheh , de Vries Antoine AF , Mojarrad Majid , Naderi‐Meshkin Hojjat , Neshati Zeinab , Kerachian Mohammad Amin 
Published: April 2018

AbstractIschemic heart disease often results in myocardial infarction and is the leading cause of mortality and morbidity worldwide. Improvement in the function of infarcted myocardium is a main purpose of cardiac regenerative medicine. One possible way to reach this goal is via stem cell therapy. Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a variety of cell types but display limited cardiomyogenic differentiation potential. Members of the T‐box family of transcription factors including Tbx20 play important roles in heart development and cardiomyocyte homeostasis. Therefore, in the current study, we investigated the potential of Tbx20 to enhance the cardiomyogenic differentiation of human adipose‐derived MSCs (ADMSCs). Human ADMSCs were transduced with a bicistronic lentiviral vector encoding Tbx20 (murine) and the enhanced green fluorescent protein (eGFP) and analyzed 7 and 14 days post transduction. Transduction of human ADMSCs with this lentiviral vector increased the expression of the cardiomyogenic differentiation markers ACTN1, TNNI3, ACTC1, NKX2.5, TBX20 (human), and GATA4 as revealed by RT‐qPCR. Consistently, immunocytological results showed elevated expression of α‐actinin and cardiac troponin I in these cells in comparison to the cells transduced with control lentiviral particles coding for eGFP alone. Accordingly, forced expression of Tbx20 exerts cardiomyogenic effects on human ADMSCs by increasing the expression of cardiomyogenic differentiation markers at the RNA and protein level.
Histopathological lesions and toxicity in common carp (Cyprinus carpio L. 1758) induced by copper nanoparticles
Authors: Forouhar Vajargah Mohammad , Mohamadi Yalsuyi Ahmad , Hedayati Aliakbar , Faggio Caterina 
Published: April 2018

AbstractDifferent types of metal oxide nanoparticles (NPs) have been suggested for various applications such as water treatment and construction of agricultural pesticides; however, there are concerns about the potential toxicity of these compounds for the nontarget organism especially aquatic organisms. The aims of this study were assessing toxicity and histopathological effects of copper oxide NPs (NPs‐CuO) on common carp (Cyprinus carpio) as a model organism. For this purpose 150 common carp with an average weight 7 ± 1 g were exposed to 0, 10, 20, 30, 40, 60, 80, 100, 150, and 200 mg/l of CuO‐NPs (10 treatment with three replicates) for 96 hrs. After 24, 48, 72, and 96 hrs exposures, mortality rates recorded and gill samples were collected. Statistical analysis showed significant differences in carp survival between control and treatment groups (p < 0.05); regression between fish mortality rate and NPs‐CuO concentration was also revealed (p < 0.01). The LC50 96h of NPs‐CuO for common carp was estimated as 124.9 mg/l in this study. Various tissue damages were observed in gill of treatments; such as, hypertrophy, hyperplasia, lamellar fusions, erythrocyte infiltration, epithelial lifting; also, there was significant correlation between intensity of tissue lesions and concentration of NPs‐CuO (p < 0.01). The findings of the present study demonstrate that sublethal concentration of NPs‐CuO can lead to serious tissue lesions. Whats more, concentrations above 30 ml/l of NPs‐CuO can lead to some clinical signs; such as skin darkening and death with open mouth as well as definite fish death.
When white collar criminals turn to fatal violence: The impact of narcissism and psychopathy
Authors: Alalehto Tage , Azarian Reza 
Published: April 2018

AbstractThe present article takes as its point of departure Perri's view, according to whom the impact of personality traits such as psychopathy and narcissism has unduly been omitted in research on white collar criminality. However, this article argues that although such factors have an important role to play in some cases when white collar criminals turn violent in order to prevent the detection of their felonies, they constitute neither the necessary nor the sufficient conditions for white collar criminals to commit murders. This means on the one hand that, although potentially increasing the risk for violence, these traits are not by themselves sufficient as the triggers of violent acts and can function so only under certain social‐contextual circumstances. However, such personality traits are not by themselves necessary, as there can be empirical cases of fraud detection murder committed by white collar criminals lacking them. This position is supported by both a logical analysis of Perri's main arguments and by empirical evidence, consisting of a few real‐life cases of Scandinavian white collar criminals who have “turned red.”
Spontaneous transformation of a concealed to manifest posteroseptal accessory pathway requiring epicardial ablation
Authors: Lee Adam , Lindemann James , Davison Oscar , Wright Daniel , Denman Russell 
Published: April 2018

AbstractConcealed accessory pathways (APs) are considered benign as they can only sustain orthodromic atrioventricular re‐entrant tachycardia (ORT). We describe a unique case of a concealed posteroseptal AP where longitudinal surveillance following repeated failed ablation attempts due to abnormal coronary sinus (CS) anatomy revealed spontaneous development of manifest pre‐excitation. The pathway was ultimately ablated via the percutaneous epicardial approach. The potential for development of Wolff‐Parkinson‐White (WPW) syndrome in patients with concealed APs has implications for ongoing surveillance in these patients.
Comparison of the efficacy between impedance‐guided and contact force‐guided atrial fibrillation ablation using an automated annotation system
Authors: Park Hyoung‐Seob , Kim In‐Cheol , Cho Yun‐Kyeong , Yoon Hyuck‐Jun , Kim Hyungseop , Nam Chang‐Wook , Han Seongwook , Hur Seung‐Ho , Kim Yoon‐Nyun , Kim Kwon‐Bae 
Published: April 2018

AbstractBackgroundThis study compared the efficacy of catheter ablation of atrial fibrillation (AF) between impedance (IMP)‐guided and contact force (CF)‐guided annotation using the automated annotation system (VisiTag™).MethodsFifty patients undergoing pulmonary vein isolation (PVI) for AF were randomized to the IMP‐guided or CF‐guided groups. The annotation criteria for VisiTag™ were a 10 second minimum ablation time and 2 mm maximum catheter movement range. A minimum CF of 10 g was added to the criteria in the CF‐guided group. In the IMP‐guided group, a minimum IMP drop of over 5 Ω was added to the criteria.ResultsThe rates of successful PVI after an initial ablation line were higher in the CF‐guided group (80% vs 48%, P = .018). Although average CF was similar between two groups, the average force‐time integral (FTI) was significantly higher in the CF‐guided group (298.3 ± 65. 2 g·s vs 255.1 ± 38.3 g·s, P = .007). The atrial arrhythmia‐free survival at 1 year demonstrated no difference between the two groups (84.0% in the IMP‐guided group vs 80.0% in the CF‐guided group, P = .737). If the use of any antiarrhythmic drug beyond the blanking period was considered as a failure, the clinical success rate at 1 year was 52.0% for the CF‐guided group vs 56.0% for the IMP‐guided group (P = .813).ConclusionsAtrial fibrillation ablation using an automated annotation system guided by CF improved the success rate of PVI after the initial circumferential ablation. An IMP‐guided annotation combined with catheter stability criteria showed similar clinical outcomes as compared to the CF‐guided annotation.
Multifoci effects of injustice on counterproductive work behaviors and the moderating roles of symbolization and victim sensitivity
Authors: Lavelle James J. , Harris Christopher M. , Rupp Deborah E. , Herda David N. , Young Randall F. , Hargrove M. Blake , Thornton‐Lugo Meghan Ann , McMahan Gary C. 
Published: April 2018

SummaryPast research suggests that employees, in response to workplace experiences, selectively engage in targeted counterproductive work behaviors (CWBs). Taking a retributive justice and target similarity perspective, we predict that employee perceptions of unfairness from the organization uniquely predict CWB specifically targeted at the organization whereas employee perceptions of supervisory unfairness uniquely predict CWB specifically targeted at the supervisor. We further hypothesized that moral identity‐symbolization would strengthen these target‐similar relationships. Finally, drawing from the sensitivity to mean intentions model, we hypothesized that victim sensitivity would not only strengthen these target‐similar relationships but also lead to cross‐foci effects of multifoci fairness perceptions on targets of CWB. Results from 3 field studies of full‐time employees provided support for most of our hypothesized relationships.
Influence Factors on Contrast Agent Venous Intravasation During Transvaginal 4‐Dimensional Hysterosalpingo‐Contrast Sonography
Authors: Wang Weiqun , Zhou Qiulan , Zhou Xingxing , Chen Zhiyi , Zhang Hui 
Published: April 2018

ObjectivesTo explore the risk factors on contrast agent venous intravasation during transvaginal 4‐dimensional hysterosalpingo‐contrast sonography (TVS 4D‐HyCoSy).MethodsThe TVS 4D‐HyCoSy imaging data were collected from 276 female infertile patients. The correlation between endometrial thickness, days after menstruation, intrauterine intervention history, fallopian tubal patency degree, and contrast agent venous intravasation, respectively, was analyzed.ResultsIn our study, the incidence of contrast agent venous intravasation was 13.04%. Endometrial thickness and days after menstruation were significantly associated with venous intravasation (P < .05). However, there was no significance for intrauterine intervention history and fallopian tube patency degree.ConclusionsContrast agent intravasation during TVS 4D‐HyCoSy is not infrequent. Performing TVS 4D‐HyCoSy according to endometrial thickness and menstrual period could reduce intravasation incidence to some extent.
Pipes or chimneys? For carbon cycling in small boreal lakes, precipitation matters most
Authors: de Wit Heleen A. , Couture Raoul‐Marie , Jackson‐Blake Leah , Futter Martyn N. , Valinia Salar , Austnes Kari , Guerrero Jose‐Luis , Lin Yan 
Published: April 2018

AbstractAre small lakes passive pipes transporting terrigenous organic carbon (dissolved organic carbon [DOC]), or chimneys for CO2 release in the landscape? Using a unique combination of 30‐yr measurements, sediment dating and modeling of a small humic lake and its catchment in southeast Norway, we calculated lateral DOC fluxes and in‐lake retention. Concentrations and fluxes rose significantly, driven by declining sulfur deposition and increased precipitation. In‐lake retention (% of inputs) declined because of higher discharge and lower residence times. DOC removal rates were not sensitive to residence time. Modeled in‐lake DOC removal was driven primarily by microbial metabolism and, secondarily, by flocculation, suggesting that the likely fate of lake‐retained DOC is CO2 evasion to the atmosphere. Precipitation was the overriding landscape control on DOC fluxes and retention. In a wetter climate, small northern lakes will, on balance, function more as pipes than chimneys, with increasing lateral DOC fluxes but little change in CO2 production.