bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of weak hip abduction strength with nocturia in older women: The Nagahama study
Authors: Tabara Yasuharu , Ikezoe Tome , Matsumoto Takeshi , Murase Kimihiko , Setoh Kazuya , Funada Satoshi , Kawaguchi Takahisa , Nagashima Shunsuke , Kosugi Shinji , Hirai Toyohiro , Nakayama Takeo , Wakamura Tomoko , Chin Kazuo , Ichihashi Noriaki , Tsuboyama Tadao , Matsuda Fumihiko 
Published: September 2019

AimNocturia is a common phenomenon in older individuals, and is associated with poor quality of life. Nocturia is a multifactorial disorder, wherein the frailty of skeletal muscles, particularly muscle weakness in the lower trunk and hip regions, might be a risk factor in women. We analyzed a dataset of the general Japanese population to clarify the hypothesis.MethodsStudy participants included 1207 older women (mean age 67.4 ± 5.2 years). The frequency of nocturnal urination was assessed using a sleep diary for 1 week, and associations with lower muscle strength, skeletal muscle index, sarcopenia and physical performance (one‐leg standing time and Timed Up and Go test) were investigated.ResultsThe frequency of nocturnal urination more than one voiding per night was 28.1%; this frequency was inversely associated with hip abduction strength quartiles (Q1: 37.0, Q2: 30.5, Q3: 25.1 and Q4: 19.9%, P < 0.001). When a sleep diary‐based nocturnal urination frequency >1.5 times/night (corresponding to a ≥2 times/night frequency obtained by questionnaire) was considered as nocturia, logistic regression analysis adjusted for major covariates identified hip abduction strength as an independent inverse determinant of nocturia (odds ratio 0.75, 95% CI 0.52–0.90, P = 0.002). In contrast, no significant association was observed with knee extension (P = 0.322) and hip flexion (P = 0.603) strengths. Physical performance, skeletal muscle index and sarcopenia did not show significant associations with nocturia.ConclusionsWeak hip abduction strength might be a factor associated with nocturnal urination frequency in older women. Geriatr Gerontol Int 2019; 19: 1010–1016.
Capturing cluster life cycle with a mixed‐method analysis: Evidence from a French cluster case study
Authors: Bernela Bastien , Ferru Marie , Depret Marc‐Hubert 
Published: September 2019

AbstractThis article contributes to the growing literature on cluster life cycles (CLC) by demonstrating the opportunities offered by a mixed‐method approach. The combination of qualitative and quantitative data is useful both to describe the evolution of network patterns and to provide an understanding of the drivers of CLC. Based on the literature, we rely on a theoretical background integrating the pre‐existing context (cognitive, institutional, and social) in which actors involved in the nascent cluster are embedded, in order to capture the impact of the genesis period on the cluster's subsequent trajectory. The operationalization of this mixed‐method focused on one case study highlights the determining period of the genesis, since CLC is rooted in (a) the building of interpersonal relationships between actors from science and industry, (b) a longstanding specialization in a technological domain, and (c) policy opportunities and guidelines. The cluster trajectory remains driven by the initial policies, the cluster's nascent specialization and the founders' pre‐existing relationships over time, with an evolving role of each type of embeddedness over time.
Assessment of the influence of transrectal and transperineal prostate biopsies on erectile function: A prospective observational single‐center study
Authors: García Rojo Esther , García Gómez Borja , González Padilla Daniel A , Abad López Pablo , García González Lucía , Rodríguez Antolín Alfredo , Romero Otero Javier 
Published: September 2019

ObjectivesTo assess the impact of transrectal versus transperineal prostate biopsy on erectile function.MethodsThis was a single‐center, observational, prospective study of consecutive patients who underwent a prostate biopsy (transrectal or transperineal/fusion biopsy). Study participants completed the International Index of Erectile Function‐5 questionnaire before the procedure, and 3 and 6 months after. Prostatic biopsies were carried out following the standard procedure for both techniques.ResultsThe study included 135 male patients with a mean age of 63.5 years. At baseline, 28 patients (21%) presented normal erectile function, whereas 107 patients (82%) presented erectile dysfunction, which was severe in four (3%), moderate in 49 (36%) and mild in 54 (40%), with an overall mean International Index of Erectile Function‐5 score of 17.70. After 3 months, the rates were 29%, 3%, 27% and 38%, respectively (mean International Index of Erectile Function‐5 score 17.95). At 6 months, the rates were 30%, 6%, 28% and 34%, respectively (mean International Index of Erectile Function‐5 score of 17.77). No significant differences between pre‐ and post‐biopsy International Index of Erectile Function‐5 scores at 3 and 6 months were observed, even when analyzing transrectal and transperineal separately. The number of biopsy cores and number of previous biopsies did not influence the International Index of Erectile Function‐5 scores.ConclusionsOur findings suggest that prostate biopsy technique, number of biopsy cores and history of previous biopsy do not significantly impact erectile function in the medium term up to 6 months.
An empirical examination of the use of Easy Read health information in health consultations involving patients with intellectual disabilities
Authors: Chinn Deborah 
Published: September 2019

AbstractBackgroundEasy Read health information (ERHI) has the potential to promote engagement in health care for people with intellectual disabilities. This study examined how ERHI was actually employed by clinicians and received by patients.MethodVideo recordings were made of 32 patients with intellectual disabilities attending a health check with primary care clinicians who had been given access to a range of ERHI, and 9 attending a health appointment with a specialist intellectual disability nurse. The recordings were analysed using conversation analysis.ResultsEasy Read health information was visible in only 7 (22%) of the primary care health checks (though not always shared with the patients). Easy Read health information was used in sequences where clinicians offered unsolicited health advice and met with degrees of resistance from patients, though its potential for shared decision making was also evident.ConclusionsEasy Read health information can aid patient understanding and decision making, but attention should be paid to the interactional practices accompanying their use.
Applications of sequencing technology in clinical microbial infection
Authors: Yu Xiaoling , Jiang Wenqian , Shi Yang , Ye Hanhui , Lin Jun 
Published: September 2019

AbstractInfectious diseases are a type of disease caused by pathogenic microorganisms. Although the discovery of antibiotics changed the treatment of infectious diseases and reduced the mortality of bacterial infections, resistant bacterial strains have emerged. Anti‐infective therapy based on aetiological evidence is the gold standard for clinical treatment, but the time lag and low positive culture rate of traditional methods of pathogen diagnosis leads to relative difficulty in obtaining the evidence of pathogens. Compared with traditional methods of pathogenic diagnosis, next‐generation and third‐generation sequencing technologies have many advantages in the detection of pathogenic microorganisms. In this review, we mainly introduce recent progress in research on pathogenic diagnostic technology and the applications of sequencing technology in the diagnosis of pathogenic microorganisms. This review provides new insights into the application of sequencing technology in the clinical diagnosis of microorganisms.
Prognostic power of a lipid metabolism gene panel for diffuse gliomas
Authors: Wu Fan , Zhao Zheng , Chai Rui‐Chao , Liu Yu‐Qing , Li Guan‐Zhang , Jiang Hao‐Yu , Jiang Tao 
Published: September 2019

AbstractLipid metabolism reprogramming plays important role in cell growth, proliferation, angiogenesis and invasion in cancers. However, the diverse lipid metabolism programmes and prognostic value during glioma progression remain unclear. Here, the lipid metabolism‐related genes were profiled using RNA sequencing data from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) database. Gene ontology (GO) and gene set enrichment analysis (GSEA) found that glioblastoma (GBM) mainly exhibited enrichment of glycosphingolipid metabolic progress, whereas lower grade gliomas (LGGs) showed enrichment of phosphatidylinositol metabolic progress. According to the differential genes of lipid metabolism between LGG and GBM, we developed a nine‐gene set using Cox proportional hazards model with elastic net penalty, and the CGGA cohort was used for validation data set. Survival analysis revealed that the obtained gene set could differentiate the outcome of low‐ and high‐risk patients in both cohorts. Meanwhile, multivariate Cox regression analysis indicated that this signature was a significantly independent prognostic factor in diffuse gliomas. Gene ontology and GSEA showed that high‐risk cases were associated with phenotypes of cell division and immune response. Collectively, our findings provided a new sight on lipid metabolism in diffuse gliomas.
Myoferlin, a multifunctional protein in normal cells, has novel and key roles in various cancers
Authors: Zhu Wei , Zhou Bolun , Zhao Chenxuan , Ba Zhengqing , Xu Hongjuan , Yan Xuejun , Liu Weidong , Zhu Bin , Wang Lei , Ren Caiping 
Published: September 2019

AbstractMyoferlin, a protein of the ferlin family, has seven C2 domains and exhibits activity in some cells, including myoblasts and endothelial cells. Recently, myoferlin was identified as a promising target and biomarker in non‐small‐cell lung cancer, breast cancer, pancreatic adenocarcinoma, hepatocellular carcinoma, colon cancer, melanoma, oropharyngeal squamous cell carcinoma, head and neck squamous cell carcinoma, clear cell renal cell carcinoma and endometrioid carcinoma. This evidence indicated that myoferlin was involved in the proliferation, invasion and migration of tumour cells, the mechanism of which mainly included promoting angiogenesis, vasculogenic mimicry, energy metabolism reprogramming, epithelial‐mesenchymal transition and modulating exosomes. The roles of myoferlin in both normal cells and cancer cells are of great significance to provide novel and efficient methods of tumour treatment. In this review, we summarize recent studies and findings of myoferlin and suggest that myoferlin is a novel potential candidate for clinical diagnosis and targeted cancer therapy.
Differentiated Integration and Disintegration in the EU after Brexit: Risks versus Opportunities
Authors: Leruth Benjamin , Gänzle Stefan , Trondal Jarle 
Published: September 2019

AbstractDifferentiation is becoming an increasingly salient feature of European integration. The multifaceted European crisis and the subsequent Brexit vote (paving the way for a ground‐breaking case of differentiated disintegration) have led scholars and practitioners to think about the consequences of differentiated integration. This article draws on five empirical models of differentiation experienced by countries both inside and outside the EU: the European economic area model, the Danish model of (quasi‐)permanent differentiation, the Swedish model of de facto differentiation, the instrumental model and the Brexit process of differentiation. It addresses the different risks and opportunities that each of these models entail. The article also introduces the contributions to this symposium, which aims at paving the way for future research on the consequences of differentiation in light of Brexit.
Predicting women's intentions to screen for breast cancer based on the health belief model and the theory of planned behavior
Authors: Wang Xinbo , Chen Dandan , Xie Tingting , Zhang Wei 
Published: September 2019

AbstractAimThe objective of this study is to identify the role of factors influencing women's breast cancer screening (BCS) intentions in Changchun city based on the health belief model (HBM) and the theory of planned behavior (TPB).MethodsA cross‐sectional study of 422 women aged 17–75 years was conducted in Changchun, northern China, in 2018. Data were collected using a questionnaire that included three parts. We used descriptive analysis, correlation analysis and multiple regressions to analyze data in spss version 23.0.ResultsCareer (P = 0.004), clinical examination (P = 0.002), X‐ray examination (P = 0.026), screening costs accepted (100–300 RMB) (P = 0.001), perceived behavioral benefit (P = 0.000), self‐efficacy (P = 0.000), subjective norms (P = 0.000), behavioral attitudes (P = 0.000) and perceived behavioral control (P = 0.000) had significant associations with BCS intentions. This study tested the applicability of the HBM (adjusted R2 = 4.7%, ΔR2 = 5.6%) and the TPB (adjusted R2 = 8.3%, ΔR2 = 3.8%) in the prediction of BCS intentions. It was found that the predictive power of the integrated model (adjusted R2 = 39%, ΔR2 = 30.8%) is better than that of each of the single models. Therefore, the integrated model has better predictive power.ConclusionAn exploration of the factors affecting BCS intentions based on the HBM and the TPB is beneficial for reduced mortality and the development of measures to increase women's BCS awareness, thus providing a basis for future research on the factors affecting BCS intentions.
The iron record of asteroidal processes in carbonaceous chondrites
Authors: Garenne A. , Beck P. , Montes‐Hernandez G. , Bonal L. , Quirico E. , Proux O. , Hazemann J.L. 
Published: September 2019

AbstractThe valence of iron has been used in terrestrial studies to trace the hydrolysis of primary silicate rocks. Here, we use a similar approach to characterize the secondary processes, namely thermal metamorphism and aqueous alteration, that have affected carbonaceous chondrites. X‐ray absorption near‐edge structure spectroscopy at the Fe‐K‐edge was performed on a series of 36 CM, 9 CR, 10 CV, and 2 CI chondrites. While previous studies have focused on the relative distribution of Fe0 with respect to oxidized iron (Feox = Fe2+ + Fe3+) or the iron distribution in some specific phases (e.g., Urey–Craig diagram; Urey and Craig 1953), our measurements enable us to assess the fractions of iron in each of its three oxidation states: Fe0, Fe2+, and Fe3+. Among the four carbonaceous chondrites groups studied, a correlation between the iron oxidation index (IOI = [2(Fe2+) + 3(Fe3+)]/[FeTOT]) and the hydrogen content is observed. However, within the CM group, for which a progressive alteration sequence has been defined, a conversion of Fe3+ to Fe2+ is observed with increasing degree of aqueous alteration. This reduction of iron can be explained by an evolution in the mineralogy of the secondary phases. In the case of the few CM chondrites that experienced some thermal metamorphism, in addition to aqueous alteration, a redox memory of the aqueous alteration is present: a significant fraction of Fe3+ is present, together with Fe2+ and sometimes Fe0. From our data set, the CR chondrites show a wider range of IOI from 1.5 to 2.5. In all considered CR chondrites, the three oxidation states of iron coexist. Even in the least‐altered CR chondrites, the fraction of Fe3+ can be high (30% for MET 00426). This observation confirms that oxidized iron has been integrated during formation of fine‐grained amorphous material in the matrix (Le Guillou and Brearley 2014; Le Guillou et al. 2015; Hopp and Vollmer 2018). Last, the IOI of CV chondrites does not reflect the reduced/oxidized classification based on metal and magnetite proportions, but is strongly correlated with petrographic types. The valence of iron in CV chondrites therefore appears to be most closely related to thermal history, rather than aqueous alteration, even if these processes can occur together (Krot et al. 2004; Brearley and Krot 2013).
The age of Wolfe Creek meteorite crater (Kandimalal), Western Australia
Authors: Barrows Timothy T. , Magee John , Miller Gifford , Fifield L. Keith 
Published: September 2019

AbstractWolfe Creek crater lies in northwestern Australia at the edge of the Great Sandy Desert. Together with Meteor Crater, it is one of the two largest craters on Earth from which meteorite fragments have been recovered. The age of the impact is poorly constrained and unpublished data places the event at about 300,000 years ago. In comparison, Meteor Crater is well constrained by exposure dating. In this paper, we present new ages for Wolfe Creek Crater from exposure dating using the cosmogenic nuclides 10Be and 26Al, together with optically stimulated luminescence ages (OSL) on sand from a site created by the impact. We also present a new topographic survey of the crater using photogrammetry. The exposure ages range from ~86 to 128 ka. The OSL ages indicate that the age of the impact is most likely to be ~120 ka with a maximum age of 137 ka. Considering the geomorphic setting, the most likely age of the crater is 120 ± 9 ka. Last, we review the age of Meteor Crater in Arizona. Changes in production rates and scaling factors since the original dating work revise the impact age to 61.1 ± 4.8 ka, or ~20% older than previously reported.
Silica minerals in cumulate eucrites: Insights into their thermal histories
Authors: Ono Haruka , Takenouchi Atsushi , Mikouchi Takashi , Yamaguchi Akira 
Published: September 2019

AbstractSome eucrites contain up to 10 vol% silica minerals; however, silica minerals have not been studied in detail so far. We performed a mineralogical study of silica minerals in three cumulate eucrites (Moore County, Moama, and Yamato [Y] 980433). Monoclinic tridymite was common in all three samples. Moama contained orthorhombic tridymite as lamellae within monoclinic tridymite grains. Y 980433 included quartz around an impact melt vein. The presence of orthorhombic tridymite in Moama indicates that Moama cooled more rapidly than the other two samples at low temperatures (<400 °C). This result is different from the slower cooling rates of Moama (≳0.0004 °C yr−1) than that of Moore County (>0.3 °C yr−1, after the shock event) at high temperatures (>500 °C) estimated from compositional profiles of pyroxene exsolution lamellae. The difference of the cooling rates may reflect their geological settings. Y 980433 cooled slowly at low temperature, as did Moore County. Quartz in Y 980433 could be a local product transformed from monoclinic tridymite by a shock event. We suggest that silica minerals in meteorites record thermal histories at low temperatures and shock events.
A deep learning algorithm for simulating autonomous driving considering prior knowledge and temporal information
Authors: Chen Sikai , Leng Yue , Labi Samuel 
Published: September 2019

AbstractAutonomous vehicle (AV) stakeholders continue to seek assurance of the safety performance of this new technology through AV testing on in‐service roads, AV‐dedicated road networks, and AV test tracks. However, recent AV‐related fatalities on in‐service roads have exacerbated public skepticism and eroded some public trust in the safety of AV operations. Further, test tracks are unable to characterize adequately the real‐world driving environment. For this reason, driving simulators continue to serve as an attractive means of AV testing. However, in most AV driving simulators, the AV operation is based on commands external to the vehicle and embedded in the code for the driving environment. To address the simulation shortfalls associated with this approach, this paper develops a deep convolutional neural network–long short‐term memory (CNN–LSTM) algorithm for self‐driving simulation. This algorithm observes and characterizes the AV's driving environment, and controls the AV movement in the driving simulation. The CNN part extracts features that use transfer learning to introduce human prior knowledge, and the LSTM part uses temporal information to process the extracted features, and incorporates temporal dynamics to predict driving decisions. The AV may also use an external server with a database containing road environment data as an additional source of information. It is acknowledged that different driving simulators differ in their functions and their capabilities to access driving‐environment data. Therefore, to make it sufficiently flexible to facilitate replication by other researchers that use driving simulators, the algorithm has been designed and demonstrated using only image data of the driving environment as input. This is because roadway image data are easily and readily accessible from the screen of any driving simulator. The proposed algorithm was tested using the open racing car simulator test track platform and was found to be able to mimic human driving decisions with a high degree of accuracy.
Health visitors’ competences before and after implementing the newborn behavioral observations (NBO) system in a community setting: A cluster randomised study
Authors: Kristensen Ingeborg H. , Vinter Merethe , Nickell Inge K. , Kronborg Hanne 
Published: September 2019

AbstractObjectiveTo explore differences between health visitors’ competences before and after implementing the newborn behavioral observations (NBO) system in four Danish municipalities.Design and SampleIn a cluster randomized design, 56 and 55 health visitors were enrolled in the intervention and comparison districts. Only health visitors from the intervention district received the NBO education programme.MeasurementsData from self‐administered questionnaires on heath visitors’ intention, self‐efficacy, knowledge, and observation skills were collected before and after NBO training. Data were analysed using descriptive and multivariable analyses.ResultsHealth visitors reported high levels of intention, self‐efficacy, and knowledge working with early parent–infant relationships in both groups at baseline. After implementing NBO, the intervention health visitors reported a significantly higher level of knowledge of infant self‐regulation than the comparison group. No significant differences were found in health visitors’ level of intention and self‐efficacy working with early parent–infant relationships, or in health visitors’ observation skills assessing the quality of early relationship.ConclusionsHealth visitors attending the NBO education and working with NBO in clinical practise had a significantly higher level of knowledge of infant self‐regulation. A new discussion of how to educate health visitors’ competencies working with early relationship in clinical practise is needed.