bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new species of Megophrys (Amphibia: Anura: Megophryidae) from the northwestern Hunan Province, China
Authors: Mo Xiaoyang , Shen Youhui , Li Honghui , Wu Xiushan 
Published: September 2019

Abstract
A new species of Megophrys (Amphibia: Anura: Megophryidae), Megophrys tuberogranulatus Shen, Mo et Li, sp. nov. (Holotype HNUL 03080902, adult male, SVL: 38.2 mm), from Sangzhi County, Hunan Province, is described. Megophrys tuberogranulatus is closely related to both Megophrys kuatunensis and Megophrys minor. Characters of the new species that differentiate this species from close relatives are skin granulated with big tubercles on the dorsal sides of both thigh and tibia, the bigger inner metacarpal tubercle, upper eyelid wider than the interorbital space, hind limbs longer, overlapping of the left and right calcaneal parts. The type specimens are deposited in the Animal Museum of Life Sciences College of Hunan Normal University.
Polytene chromosomes of an Indian Himalayan black fly Simulium (Nevermannia) praelargum (Diptera: Simuliidae)
Authors: Henry Willie , Dey Subrata Kumar , Varma Rakesh , Thapa Sachin , Procunier William S 
Published: September 2019

Abstract
High quality polytene chromosome maps (n=3) of a Himalayan Simuliid Simulium praelargum Datta, 1973 are presented and represent the first cytological description of a taxon found in the feuerborni group, subgenus Nevermannia. Polytene chromosomes one (I) and two (II) are metacentric, chromosome three (III) is submetacentric with the length of each chromosome occupying 37.25 %, 31.36 % and 31.34 % of the total complement length, respectively. Typical simuliid diagnostic intergeneric chromosomal markers are found within the polytene complement of this species. The nucleolar organizer (N.O.) is found at the base of the short arm of chromosome one (IS), the Ring of Balbiani (R.B.), double bubble (D.B.) and triad occur in the short arm of chromosome two (IIS), the Parabalbiani Ring (P.B.) and grey band (gb) occur in the long arm of chromosome two (IIL) and the Blister (BL) and Capsule (Ca) occur in the short arm of chromosome three (IIIS).Terminal bands at the end of IIIS are heterochromatinized and present atypically with respect to other simuliid fauna. Populations studied so far are unique among the Simuliidae in that they exhibit chromosome structural monomorphism. These high resolution polytene chromosome maps will form the basis for future cytological characterization and phylogenetic comparisons amongst members of the feuerborni group.
Male horseshoe crabs Limulus polyphemus use multiple sensory cues to locate mates
Authors: Saunders Katharine M. , Brockmann H. Jane , Watson Winsor H. , Jury Steven H. 
Published: September 2019

Abstract
The use of multisensory cues to locate mates can increase an organism's success by acting as a back-up plan when one system fails, by providing additional information to the receiver, and by increasing their ability to detect mates using senses that have different ranges in a variable aquatic environment. In this contribution we review the sensory cues that male horseshoe crabs Limulus polyphemus are known to use when locating mates and then provide new data that shed light on this subject. During the breeding season, females migrate into shore during high tides to spawn. Males attach to females as they approach the beach or are attracted to pairs already spawning. Vision is well established as an important cue in attracting males. Although chemoreception is well known in other marine arthropods, and horseshoe crabs have the anatomy available, there are few studies on chemical cues in this species. Experiments are presented here that provide evidence for chemical cue use. We show that the attraction, and retention, of attached and satellite males to actively spawning females and mating pairs involves multimodal cues.
Circadian regulation of Limulus visual functions: A role for octopamine and cAMP
Authors: Dalal Jasbir S. , Battelle Barbara-Anne 
Published: September 2019

Abstract
The purpose of this contribution is to review our current understanding of the source and biochemistry of the circadian efferent input to the eyes of the American horseshoe crab Limulus polyphemus and the impact of this input on the structure, physiology and biochemistry of Limulus eyes. Special emphasis is given to the role of the biogenic amine octopamine and biochemical cascades it activates in the eyes. In addition to reviewing published data, we present new data showing that octopamine elevates cAMP levels in Limulus lateral eyes, and we partially characterize the pharmacology of the receptors involved in this response. We also present new data showing that octopamine regulates gene expression in Limulus lateral eyes by activating a cAMP cascade.
Sources and significance of variation in basal, summit and maximal metabolic rates in birds
Authors: Mckechnie Andrew E. , Swanson David L. 
Published: September 2019

Abstract
The rates at which birds use energy may have profound effects on fitness, thereby influencing physiology, behavior, ecology and evolution. Comparisons of standardized metabolic rates (e.g., lower and upper limits of metabolic power output) present a method for elucidating the effects of ecological and evolutionary factors on the interface between physiology and life history in birds. In this paper we review variation in avian metabolic rates [basal metabolic rate (BMR; minimum normothermic metabolic rate), summit metabolic rate (Msum; maximal thermoregulatory metabolic rate), and maximal metabolic rate (MMR; maximal exercise metabolic rate)], the factors associated with this variation, the evidence for functional links between these metabolic traits, and the ecological and evolutionary significance of avian metabolic diversity. Both lower and upper limits to metabolic power production are phenotypically flexible traits, and vary in association with numerous ecological and evolutionary factors. For both inter- and intraspecific comparisons, lower and upper limits to metabolic power production are generally upregulated in response to energetically demanding conditions and downregulated when energetic demands are relaxed, or under conditions of energetic scarcity. Positive correlations have been documented between BMR, Msum and MMR in some, but not all studies on birds, providing partial support for the idea of a functional link between lower and upper limits to metabolic power production, but more intraspecific studies are needed to determine the robustness of this conclusion. Correlations between BMR and field metabolic rate (or daily energy expenditure) in birds are variable, suggesting that the linkage between these traits is subject to behavioral adjustment, and studies of the relationship between field and maximal metabolic rates are lacking. Our understanding of avian metabolic diversity would benefit from future studies of: (1) the functional and mechanistic links between lower and upper limits of metabolic power output; (2) the environmental and ecological cues driving phenotypically flexible metabolic responses, and how responses to such cues might impact population responses to climate change; (3) the shapes of metabolic reaction norms and their association with environmental variability; and (4) the relationship of metabolic variation to fitness, including studies of repeatability and heritability of minimum and maximum metabolic power output.
Flank gland-secreted putative chemosignals pertaining to photoperiod, endocrine states, and sociosexual behavior in golden hamsters
Authors: Liu Ying-Juan , Wang Da-Wei , Sun Lixing , Zhang Jin-Hua , Zhang Jian-Xu 
Published: September 2019

Abstract
Behavioral studies have shown that flank glands are involved in chemical communication in golden hamsters Mesocricetus auratus but little chemical analysis has been conducted on volatiles arising from these glands. Using gas chromatography- mass spectrometry, we detected compounds from the flank glands of males, only eight of which were also produced in females. Based on these chemical data we performed a number of further experiments. By manipulating light we found that males exposed to short-photoperiods developed smaller flank glands than those exposed to long-photoperiods. Six flank gland volatiles reduced in relative abundance, which possibly coded for reproductive status of males of this seasonally breeding hamster species. Through dyadic encounters, we were able to induce the formation of dominant-subordinate relationships and show that two glandular compounds became high in relative abundance and may function as dominance pheromones. Castration eliminated all male-specific compounds resulting from flank glands, but bilateral ovariectomies only affected one compound in females. Once these ovariectomized females were treated with testosterone, their glandular compounds resembled those of males, suggesting these compounds are under the main control of androgen. Two female putative pheromones, tetradecanoic acid and hexadecanoic acid, were used in binary choice tests and were both found to attract males over females. Applying a solution of these pheromone compounds to adult males also suppressed their agonistic behavior.
Roles of the main olfactory and vomeronasal systems in the detection of androstenone in inbred strains of mice
Authors: Voznessenskaya Vera V. , Klyuchnikova Maria A. , Wysocki Charles J. 
Published: September 2019

Abstract
We investigated the role of the main olfactory and accessory olfactory systems (MOS and AOS respectively) in the detection of androstenone. We used the following experimental approaches: behavioral, surgical removal of the vomeronasal organ (VNX) followed by histochemical verification and Fos immunohistochemistry. Using a Y-maze paradigm we estimated sensitivity of NZB/B1NJ and CBA/J mice to androstenone. CBA mice were 2,000-fold more sensitive to androstenone than NZB mice. VNX caused a 4- to16-fold decrease in sensitivity to androstenone in highly-sensitive CBA mice, but did not affect thresholds in NZB mice. Results indicate the involvement of the MOS and AOS in the detection of androstenone. We observed a specific pattern of Fos-positive cells in the main olfactory bulb of CBA mice but not in NZB mice subsequent to exposure of mice to androstenone; the compound activated cells in the accessory olfactory bulb in both strains of mice, indicating the involvement of the vomeronasal organ. Patterns of Fos-positive cells in the vomeronasal organ were recorded subsequent to exposure to androstenone. Fos-positive receptor cells in the vomeronasal organ of CBA and NZB mice were different, in CBA mice Fos-positive cells were noted in both the basal and apical zones, however, in NZB mice activation was observed only in the apical zone.
Neurobiology of mammalian olfactory learning that occurs during sensitive periods
Authors: Kaba Hideto 
Published: September 2019

Abstract
This review examines the organizational principles underlying olfactory learning in three specialized contexts that occur during sensitive periods of enhanced neural plasticity and emphasizes some of their common features. All three forms of olfactory learning are associated with neural changes in the olfactory bulb (OB) at the first stage of sensory processing. These changes require the association of the olfactory and somatosensory signals in the OB. They all depend on somatosensory stimulation- induced release of noradrenaline that induces structural and functional changes at mitral-granule cell reciprocal synapses in the OB, resulting in increases in inhibitory transmission. In the accessory olfactory bulb, this represents the enhanced self-inhibition of mitral cells, which selectively disrupts the transmission of the mating male's pregnancy-blocking signal at this level. In contrast, an extensive network of secondary dendrites of mitral cells in the main olfactory bulb probably results in a sharpening of the odor-induced pattern of activity, due to increases in lateral inhibition, leading to offspring recognition in sheep and neonatal learning in rats and rabbits. These findings show that inhibitory interneurons play a critical role in olfactory learning. Further work on how these neurons shape olfactory circuit function could provide important clues to understand memory functions of interneurons in other systems. Moreover, recent research has suggested that three forms of olfactory learning are controlled by synergistic, redundant, and distributed neural mechanisms. This has general implications regarding the mechanisms that may contribute to the robustness of memories.
Identification of tRNA-derived ncRNAs in TCGA and NCI-60 panel cell lines and development of the public database tRFexplorer
Authors: La Ferlita Alessandro , Alaimo Salvatore , Veneziano Dario , Nigita Giovanni , Balatti Veronica , Croce Carlo M , Ferro Alfredo , Pulvirenti Alfredo 
Published: September 2019

Abstract
Next-generation sequencing is increasing our understanding and knowledge of non-coding RNAs (ncRNAs), elucidating their roles in molecular mechanisms and processes such as cell growth and development. Within such a class, tRNA-derived ncRNAs have been recently associated with gene expression regulation in cancer progression. In this paper, we characterize, for the first time, tRNA-derived ncRNAs in NCI-60. Furthermore, we assess their expression profile in The Cancer Genome Atlas (TCGA). Our comprehensive analysis allowed us to report 322 distinct tRNA-derived ncRNAs in NCI-60, categorized in tRNA-derived fragments (11 tRF-5s, 55 tRF-3s), tRNA-derived small RNAs (107 tsRNAs) and tRNA 5′ leader RNAs (149 sequences identified). In TCGA, we were able to identify 232 distinct tRNA-derived ncRNAs categorized in 53 tRF-5s, 58 tRF-3s, 63 tsRNAs and 58 5′ leader RNAs. This latter group represents an additional evidence of tRNA-derived ncRNAs originating from the 5′ leader region of precursor tRNA. We developed a public database, tRFexplorer, which provides users with the expression profile of each tRNA-derived ncRNAs in every cell line in NCI-60 as well as for each TCGA tumor type. Moreover, the system allows us to perform differential expression analyses of such fragments in TCGA, as well as correlation analyses of tRNA-derived ncRNAs expression in TCGA and NCI-60 with gene and miRNA expression in TCGA samples, in association with all omics and compound activities data available on CellMiner. Hence, the tool provides an important opportunity to investigate their potential biological roles in absence of any direct experimental evidence.
Database URL: https://trfexplorer.cloud/
A general approach for improving deep learning-based medical relation extraction using a pre-trained model and fine-tuning
Authors: Chen Tao , Wu Mingfen , Li Hexi 
Published: September 2019

Abstract
The automatic extraction of meaningful relations from biomedical literature or clinical records is crucial in various biomedical applications. Most of the current deep learning approaches for medical relation extraction require large-scale training data to prevent overfitting of the training model. We propose using a pre-trained model and a fine-tuning technique to improve these approaches without additional time-consuming human labeling. Firstly, we show the architecture of Bidirectional Encoder Representations from Transformers (BERT), an approach for pre-training a model on large-scale unstructured text. We then combine BERT with a one-dimensional convolutional neural network (1d-CNN) to fine-tune the pre-trained model for relation extraction. Extensive experiments on three datasets, namely the BioCreative V chemical disease relation corpus, traditional Chinese medicine literature corpus and i2b2 2012 temporal relation challenge corpus, show that the proposed approach achieves state-of-the-art results (giving a relative improvement of 22.2, 7.77, and 38.5% in F1 score, respectively, compared with a traditional 1d-CNN classifier). The source code is available at https://github.com/chentao1999/MedicalRelationExtraction.
Relating Aerial Deposition of Entomophaga maimaiga Conidia (Zoopagomycota: Entomophthorales) to Mortality of Gypsy Moth (Lepidoptera: Erebidae) Larvae and Nearby Defoliation
Authors: Elkinton Joseph S , Bittner Tonya D , Pasquarella Valerie J , Boettner George H , Liebhold Andrew M , Gould Juli R , Faubert Heather , Tewksbury Lisa , Broadley Hannah J , Havill Nathan P , Hajek Ann E 
Published: September 2019

AbstractWe collected data on mortality of late-instar gypsy moth, Lymantria dispar (L.), from outbreak populations over 4 wk in June 2017 at 10 sites in the New England region of the United States, along with estimated rainfall at these sites. Deposition of airborne conidia of the fungal pathogen, Entomophaga maimaiga Humber, Shimazu & R.S. Soper, was measured at these same sites as well as at seven other locations in New England. We also quantified the geographical distribution of gypsy moth-caused defoliation in New England in 2017 and 2018 from Landsat imagery. Weekly mortality of gypsy moth larvae caused by E. maimaiga correlated with local deposition of conidia from the previous week, but not with rainfall. Mortality from this pathogen reached a peak during the last 2 wk of gypsy moth larval development and always exceeded that caused by LdNPV, the viral pathogen of gypsy moth that has long been associated with gypsy moth outbreaks, especially prior to 1989. Cotesia melanoscela (Ratzeburg) was by far the most abundant parasitoid recovered and caused an average of 12.6% cumulative parasitism, but varied widely among sites. Deposition of E. maimaiga conidia was highly correlated with percent land area defoliated by gypsy moths within distances of 1 and 2 km but was not significantly correlated with defoliation at distances greater than 2 km. This is the first study to relate deposition of airborne conidia of E. maimaiga to mortality of gypsy moths from that agent.
Measuring price discovery in the European wheat market using the partial cointegration approach
Authors: Vollmer Teresa , Herwartz Helmut , von Cramon-Taubadel Stephan 
Published: September 2019

AbstractUnderstanding price discovery in agricultural spot and futures markets is important for market participants and policy makers, because it can contribute to better management decisions and more informed policy debates on market regulation. Combining partial cointegration with state space modelling, we generate time-varying price discovery metrics for the European wheat market that allow for shifts in the long-run relationship. We find that the futures market dominates price discovery in terms of efficiency, but that this dominance is reduced in phases of higher price volatility. We find evidence of persistent shocks in the long-run relationship between spot and futures prices that appear to be related to variations in the quality of the wheat harvest, and to the concatenation of the futures prices.
Ethnic Differences in Labour Market Outcomes—The Role of Language-Based Discrimination
Authors: Schmaus Miriam 
Published: September 2019

Abstract
Host country language proficiency has been shown to account for ethnic differences in labour market outcomes. Prior studies generally assume that language skills represent a form of human capital, affecting employees’ productivity. However, language proficiency may also be associated with discrimination. Lower language proficiency may elicit distaste for certain ethnic groups, as it is a prominent reminder of the respective origin. When this reminder vanishes as language skills rise, group-specific distaste should also reduce. Employers may thus not only value language skills in terms of productivity but also factor in less group-specific distaste when evaluating immigrant jobseekers with high-language skills. Moreover, if employers lack information on competences that are hard to observe, high-language proficiency may prevent the application of adverse ethnic beliefs. Using data from the National Educational Panel Study (NEPS), I examine whether language skills affect crucial indicators of labour market success differently for groups that vary with respect to the level of distaste associated with them. I also investigate whether this effect is conditional on the amount of information available to employers. Findings indicate group-specific returns to higher-language proficiency, irrespective of the available information. This might suggest that, in addition to affecting employees’ productivity, language proficiency may also be associated with taste discrimination for certain ethnic groups.
Alcohol in TV series popular with teens: a content analysis of TV series in France 22 years after a restrictive law
Authors: Chapoton Boris , Werlen Anne-Laure , Regnier Denois Véronique 
Published: September 2019

Abstract

Background
European citizens are the largest alcohol users in the world with an average of 11 l of alcohol per individual per year being used. This consumption practice usually begins during adolescence. Youths’ views of substances consumption are built upon socialization experiments from which television takes part. To prevent vulnerable people from media influence, some governments tend to adopt restrictive laws against alcohol marketing within the public space including TV programmes; others rely on the self-control of the alcohol and/or media industry. More than 22 years ago, France adopted a restrictive law made of measures aiming to regulate or prohibit advertising of alcoholic products, especially within media dedicated to minors.

Methods
This study relies on a content analysis to identify the patterns and the frequencies of occurrences linked to alcohol within a sample of 14 TV series (8 French series and 6 American series) most watched by French teenagers. In total, 180 episodes have been analysed representing 111 h 24 min and 6 s of series coded.

Results
Alcohol is depicted within 87.8% of the sample. French series statistically show more events related to alcohol when compared to the American series. In French series, alcohol, mainly wine, is associated with a familiar lifestyle context with primary characters.

Conclusion
The restrictive law ongoing in France does not prevent popular TV programmes watched by minors to depict alcohol. Concerns should be raised about the impact of the values given to the substance integrated to main characters life within the media.
Rhizosphere-enriched microbes as a pool to design synthetic communities for reproducible beneficial outputs
Authors: Tsolakidou Maria-Dimitra , Stringlis Ioannis A , Fanega-Sleziak Natalia , Papageorgiou Stella , Tsalakou Antria , Pantelides Iakovos S 
Published: September 2019

Abstract
Composts represent a sustainable way to suppress diseases and improve plant growth. Identification of compost-derived microbial communities enriched in the rhizosphere of plants and characterization of their traits, could facilitate the design of microbial synthetic communities (SynComs) that upon soil inoculation could yield consistent beneficial effects towards plants. Here, we characterized a collection of compost-derived bacteria, previously isolated from tomato rhizosphere, for in vitro antifungal activity against soil-borne fungal pathogens and for their potential to change growth parameters in Arabidopsis. We further assessed root-competitive traits in the dominant rhizospheric genus Bacillus. Certain isolated rhizobacteria displayed antifungal activity against the tested pathogens and affected growth of Arabidopsis, and Bacilli members possessed several enzymatic activities. Subsequently, we designed two SynComs with different composition and tested their effect on Arabidopsis and tomato growth and health. SynCom1, consisting of different bacterial genera, displayed negative effect on Arabidopsis in vitro, but promoted tomato growth in pots. SynCom2, consisting of Bacilli, didn't affect Arabidopsis growth, enhanced tomato growth and suppressed Fusarium wilt symptoms. Overall, we found selection of compost-derived microbes with beneficial properties in the rhizosphere of tomato plants, and observed that application of SynComs on poor substrates can yield reproducible plant phenotypes.