bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards a poetics of immersion in lyric translation
Authors: Zhou Min 
Published: August 2018

AbstractThis study, with reference to a variety of English translations of Chinesecipoetry (詞), sets out to demonstrate a mental state of ‘aesthetic illusion’, in which the translator-as-reader gets immersed into (an) imaginary world(s) triggered by the original poems and imaginatively experiences the world(s) “in analogous ways to real-life experience” (Wolf 2013a, 11–12). It argues that the translator-as-reader’s imaginary experience of the world(s) ‘from within’ activates a variety of manifestations and implementations of narrativity, and affects the interplay between the lyric and narrative modes in the translated lyric poems. Drawing on analytical concepts and methods from cognitive narratology, aesthetic illusion, and reading psychology, this study aims at foregrounding the translator’s role as an immersive reader, a “side-participant” (Gerrig 1993) in the represented worlds, and at giving an enriched account of what the translator’s reading of the original poems involve.
Effect of sorghum ethyl-acetate extract on benign prostatic hyperplasia induced by testosterone in Sprague–Dawley rats
Authors: Ryu Jae-Myun , Jang Gwi Yeong , Park Dongsun , Woo Koan Sik , Kim Tae Myoung , Jeong Heon Sang , Kim Dae Joong 
Published: August 2018

ABSTRACT
Benign prostatic hyperplasia (BPH) is commonly observed in men &gt; 50 years worldwide. Phytotherapy is one of the many treatment options. Sorghum (Sorghum bicolor L.) contains various health-improving phytochemicals with antioxidant and inhibitory activities on cell proliferation, both in vitro and in vivo. To confirm the effects of Donganme sorghum ethyl-acetate extract (DSEE) on BPH, we induced BPH in Spragye–Dawley rats using exogenous testosterone. We measured prostate weight, examined prostrates histopathologically, and analyzed mRNAs associated with male hormones and proteins associated with cell proliferation in the prostate. DSEE inhibited weight gain of the prostate; decreased mRNA expressions of androgen receptor and 5α-reductase II; and improved histopathological symptoms, the protein-expressed ratio of Bax/Bcl-2, and the oxidative status of BPH induced by testosterone in SD rats. Therefore, DSEE may have potential as a preventive or therapeutic agent against BPH.
Nine lives of uncertainty in decision-making: strategies for dealing with uncertainty in environmental governance
Authors: Dewulf Art , Biesbroek Robbert 
Published: August 2018

ABSTRACTGoverning complex environmental issues involves intensive interaction between public and private actors. These governance processes are fraught with uncertainties about, for example, the current state of environmental affairs, the relevant set of decision alternatives, the reactions of other actors to proposed solutions or the future developments likely to affect an issue. Uncertainty comes in different shapes and sizes and different strands in the literature, which has placed emphasis either on the substance of the issue (e.g. in environmental sciences) or on the decision-making process (e.g. policy sciences). In this paper, we bring together these different strands of literature on uncertainty to present a novel analytical framework. We build on the argument that the nature of uncertainty consists of three types: epistemic uncertainty (involving the lack of knowledge about a particular system), ontological uncertainty (irreducible unpredictability due to inherently complex system behavior) and ambiguity (conflicts between fundamentally different frames about the issue at hand). Scholars have also argued the importance of differentiating between three different objects of uncertainty: substantive uncertainty (uncertainty about the content of decisions or policy issues), strategic uncertainty (uncertainty about the actions of other actors in the strategic game of decision-making) and institutional uncertainty (uncertainty about the rules of the game in decision-making). The framework is useful for analyzing and addressing the nine lives of uncertainty in decision-making. Better understanding of the range of uncertainties is crucial to design more robust policies and governance arrangements and to deal with wicked environmental problems.
Using Machine Learning-Based Multianalyte Delta Checks to Detect Wrong Blood in Tube Errors
Authors: Rosenbaum Matthew W , Baron Jason M 
Published: August 2018

AbstractObjectivesAn unfortunate reality of laboratory medicine is that blood specimens collected from one patient occasionally get mislabeled with identifiers from a different patient, resulting in so-called “wrong blood in tube” (WBIT) errors and potential patient harm. Here, we sought to develop a machine learning-based, multianalyte delta check algorithm to detect WBIT errors and mitigate patient harm.MethodsWe simulated WBIT errors within sets of routine inpatient chemistry test results to develop, train, and evaluate five machine learning-based WBIT detection algorithms.ResultsThe best-performing WBIT detection algorithm we developed was based on a support vector machine and incorporated changes in test results between consecutive collections across 11 analytes. This algorithm achieved an area under the curve of 0.97 and considerably outperformed traditional single-analyte delta checks.ConclusionsMachine learning-based multianalyte delta checks may offer a practical strategy to identify WBIT errors prior to test reporting and improve patient safety.
The Common Natural Products (S)-α-Terpineol and (E)-2-Hexenol are Important Pheromone Components of Megacyllene antennata (Coleoptera: Cerambycidae)
Authors: Mitchell Robert F , Ray Ann M , Hanks Lawrence M , Millar Jocelyn G 
Published: August 2018

AbstractWe report here the pheromone of Megacyllene antennata (White) (Coleoptera: Cerambycidae), a species native to southwestern North America whose larvae feed in woody tissues of mesquite (Prosopis species; Fabaceae). Adult males sex-specifically produced a blend of eight common natural products, including the monoterpene alcohol (S)-α-terpineol; the monoterpenes (S)-limonene and terpinolene; the aromatic alcohols (R)-1-phenylethanol and 2-phenylethanol; and (E)-2-hexenol, (E)-2-hexenal, and 1-hexanol. Individual males produced the components in varying amounts, but (S)-α-terpineol and (E)-2-hexenal were always present and together constituted the majority of the blend. A synthetic reconstruction of the complete blend attracted both males and females of M. antennata during field bioassays, as did all subsets of the blend that included (S)-α-terpineol and (E)-2-hexenol. Adults were most strongly attracted to blends of the latter two compounds when in ratios approaching parity. Neither of the compounds were present in the bouquet of volatiles emitted by host plants of the larvae.
Preparation and Planning for Future Care in the Deep South: Adapting a Validated Tool for Cultural Sensitivity
Authors: Allen Rebecca S , Oliver JoAnn S , Eichorst Morgan K , Mieskowski Lisa , Payne-Foster Pamela , Sörensen Silvia 
Published: August 2018

Abstract

Background and Objectives
This study describes the adaptation and validation of Sörensen et al. (2017)’s preparation for future care (PFC) scale with diverse samples including rural dwelling African Americans and certified nursing assistants (CNAs), and subsequent psychometric development.

Research Design and Methods
Responses to the five-subscale PFC survey from 33 rural African American men across 12 months and cognitive interviews with a subset of 12 of these men are described. Psychometric refinement included descriptive qualitative analyses of consultations with experienced lay research advisors (N = 4 and N = 7) regarding potential changes to the PFC and a confirmatory factor analysis of the resultant scale (N = 138).

Results
Cognitive interviews with rural African American men revealed difficulty understanding Eurocentric questions. Emergent themes included emotional avoidance of planning, considerations of nursing homes and possible care providers, and coping strategies. In two consultation meetings, trained lay research advisors recommended language modifications to the original questions and response options. Factor analyzing the resultant scale revealed support for the original subscale constructs (acceptable fit: χ2 = 205.03, df = 124, p < .001; root mean square error of approximation = .069 [.052–.085]; comparative fit index = .93; Tucker–Lewis index = .91).

Discussion and Implications
PFC and engagement in advance care planning is uncommon among African Americans, possibly due to distrust of and lack of cultural competency among health care professionals. The resulting tool and response options may be used as an interview guide/survey with African Americans to gain understanding about their preparation for future health care needs.
Origin and diversity of embryonic endothelium/endocardium
Authors: SaintJean LeShana , Baldwin H.S. 
Published: August 2018

Abstract
The endocardium represents a distinct population of endothelial cells that arises during the initiation of heart development. Endocardial cells can easily be distinguished from most of the other cardiac cell types. However, endocardial and vascular endothelial cells contain a similar genetic profile that limits the ability to study each group independently. Despite these limitations, tremendous progress has been made in identifying the different roles of endocardial cells throughout heart development. Initial studies focused on the origin of endocardial cells and their role in valvulogenesis, trabeculation, and formation of the ventricular and atrial septum. With the advancement of microscopy and the availability of endocardial specific reporter models (in vitro and in vivo) we have obtained more insight into the molecular, structural, and functional complexity of the endocardium. Additional studies have demonstrated how the endocardium is also involved in the development of coronary vessels within the compact myocardium and in heart regeneration.
Cardiac looping and laterality
Authors: Campione Marina , Aranega Amelia , Franco Diego 
Published: August 2018

Abstract
Dextral looping is a complex process which progresses concomitantly with cardiac chamber differentiation and ultimately leads to the final alignment of the cardiac regions. Generation of cardiac asymmetry is crucial to ensure the proper form and consequent function of the heart and thus is a highly regulated process. Molecular signals originate long before morphological asymmetry and therefore can direct it; a complex regulatory network has been characterized which invariably converges on the Tgf-β signalling molecule Nodal and its downstream target, the homeobox transcription factor Pitx2. We review current data regarding the cellular and molecular bases of cardiac looping and laterality, and describe current understaning of the role of Nodal and Pitx2. The morphogenetic role of the Pitx2 gene and its modulation of transcription and function, which have recently linked laterality to atrial fibrillation, are emphasized.
Factors Predicting the Need for Surgery of the Opposite Side After Unilateral Evacuation of Bilateral Chronic Subdural Hematomas
Authors: Motiei-Langroudi Rouzbeh , Thomas Ajith J , Ascanio Luis , Alturki Abdulrahman , Papavassiliou Efstathios , Kasper Ekkehard M , Arle Jeffrey , Alterman Ronnie L , Ogilvy Christopher S , Stippler Martina 
Published: August 2018

Abstract

BACKGROUND
Patients with bilateral chronic subdural hematoma (bCSDH) undergo unilateral evacuation for the large or symptomatic side because the contralateral hematoma is either small or asymptomatic. However, the contralateral hematoma may subsequently grow and require evacuation.

OBJECTIVE
To characterize factors that predict contralateral hematoma growth and need for evacuation.

METHODS
A retrospective study on 128 surgically treated bCSDHs.

RESULTS
Fifty-one and 77 were bilaterally and unilaterally evacuated, respectively. Glasgow Coma Scale was lower and midline shift was higher in those evacuated unilaterally compared to those evacuated bilaterally. Hematoma size was a significant determinant of decision for unilateral vs bilateral evacuation. The contralateral side needed evacuation at a later stage in 7 cases (9.1%). There was no significant difference in terms of reoperation rate between those evacuated unilaterally and bilaterally. Greater contralateral hematoma thickness on the first postoperative day computed tomography (CT) and more postoperative midline shift reversal had higher rates of operation in the opposite side. There was no difference between the daily pace of hematoma decrease in the operated and nonoperated sides (0.7% decrease per day vs 0.9% for the operated and nonoperated sides, respectively).

CONCLUSION
Results of this study show that most bCSDHs evacuated unilaterally do not experience growth in the nonoperated side and unilateral evacuation results in hematoma resolution for both sides in most cases. Hematoma thickness on the opposite side on the first postoperative day CT and amount of midline shift reversal after surgery are the most important factors predicting the need for surgery on the opposite side.
Synthetic cementum protein 1–derived peptide regulates mineralization in vitro and promotes bone regeneration in vivo
Authors: Correa Rodrigo , Arenas Jesús , Montoya Gonzalo , Hoz Lía , López Sonia , Salgado Fabiola , Arroyo Rita , Salmeron Nahúm , Romo Enrique , Zeichner-David Margarita , Arzate Higinio 
Published: August 2018

ABSTRACTThe use of recombinant proteins has revolutionized the development of biologic pharmaceuticals; however, they are not free of complications. Some have very high molecular weight, some demonstrate in vivo instability, and the high cost of producing them remains a major problem. On the other hand, it has been shown that peptides derived from active domains keep their biologic activity and can trigger events, such as osteogenesis and bone regeneration. Small peptides are advantageous because of their ease of synthesis and handling and their low immunogenic activity. The purpose of this study was to investigate the functions of a synthetic peptide, cementum protein 1‐peptidel (CEMP‐1‐p1), both in vitro and in vivo. Our results show that CEMP‐1‐p1 significantly enhanced the proliferation and differentiation of human periodontal ligament cells toward a mineralizing‐like phenotype, as evidenced by increasing alkaline phosphatase (ALP)–specific activity and osterix, runt‐related transcription factor (RUNX)‐2, integrin binding sialoprotein, bone morphogenetic protein‐2, osteocalcin, and cementum protein (CEMP)‐1 expression at mRNA and protein levels. In vivo assays performed through standardized critical‐size calvarial defects in rats treated with CEMP‐1‐p1 resulted in newly formed bone after 30 and 60 d. These data demonstrate that CEMP‐1‐p1 is an effective bioactive peptide for bone tissue regeneration. The application of this bioactive peptide may lead to implementing new strategies for the regeneration of bone and other mineralized tissues.—Correa, R., Arenas, J., Montoya, G., Hoz, L., López, S., Salgado, F., Arroyo, R., Salmeron, N., Romo, E., Zeichner‐David, M., Arzate, H. Synthetic cementum protein 1–derived peptide regulates mineralization in vitro and promotes bone regeneration in vivo. FASEB J. 33, 1167–1178 (2019). www.fasebj.org
AMH prevents primordial ovarian follicle loss and fertility alteration in cyclophosphamide‐treated mice
Authors: Sonigo Charlotte , Beau Isabelle , Grynberg Michael , Binart Nadine 
Published: August 2018

ABSTRACTThe follicular ovarian reserve, constituted by primordial follicles (PMFs), is established early in life, then keeps declining regularly along reproductive life. The maintenance of a normal female reproductive function implies the presence of a vast amount of dormant PMFs. This process involves a continuous repression of PMF activation into early growing follicle through the balance between factors activating the initiation of follicular growth, mainly actors of the PI3K signaling pathway, and inhibiting factors such as anti‐Müllerian hormone (AMH). Any disruption of this balance may induce follicle depletion and subsequent infertility. It has been recently proposed that cyclophosphamide (Cy), an alkylating agent commonly used for treating breast cancer, triggers PMF activation, further leading to premature ovarian insufficiency. Preventing chemotherapy‐induced ovarian dysfunction might represent an interesting option for preserving optimal chances of natural or medically assisted conceptions after healing. The aim of the present study was to evaluate, in a model of Cy‐treated pubertal mice, whether AMH administration might restrain PMF depletion. The counting of the total PMF number within mouse ovaries showed that recombinant AMH prevented Cy‐induced PMF loss. Western blot analysis revealed activation of PI3K signaling pathway after Cy administration. After AMH injection, FOXO3A phosphorylation, a main actor of PMF activation, was significantly decreased. Taken together, these results support a protective role of AMH against Cy‐induced follicular loss. We also provide evidence for a possible role of autophagy in the preservation of follicular pool reserve. Therefore, concomitant recombinant AMH administration during chemotherapy might offer a new option for preserving young patients' fertility.—Sonigo, C., Beau, I., Grynberg, M., Binart, N. AMH prevents primordial ovarian follicle loss and fertility alteration in cyclophosphamide‐treated mice. FASEB J. 33, 1278–1287 (2019). www.fasebj.org
Global Health Education at Home: Canadian Medical Students’ Perspectives After Learning Alongside Haitian Peers
Authors: Liauw Samantha Siu Lian , Kuper Ayelet , Noël Geoffroy , Richardson Lisa 
Published: August 2018

Purpose
To explore how host medical students learn from visiting foreign students, by reporting on a global health program that has invited two or three Haitian medical students each year since 2013 to a Canadian medical school for a summer anatomy program.

Method
In 2017, the authors conducted a qualitative descriptive study that collected data through one-on-one, semistructured interviews with 10 Canadian students, who participated in the Université Quisqueya–McGill University collaborative, a bidirectional global health education initiative, 2013–2016. The authors’ critical constructivist thematic analysis, while exploratory, was sensitized by their knowledge of contemporary frameworks of global health competencies, a postcolonial understanding of power relations, and three key concepts (agency, cultural humility, and reflexivity).

Results
The authors found two phenomena related to bidirectional exchange: the nature of the relationship between Canadian and Haitian students, and elements of the learning experience that facilitated transformation and growth. There were three important components to the nature of the relationship between Canadian and Haitian students—reflection on practices and privilege, negotiation of power dynamics, and perception of Haitian students as agents—and three components of the learning experience that facilitated transformation and growth—working in groups, common learning objectives, and informal social gatherings.

Conclusions
Bidirectional programs may have implications for Canadian students’ perception of the agency of international medical learners and may prompt self-reflection that manifests in a range of ways, including an experience of culture shock at home. These tensions seemed to create space to practice reflexivity and cultural humility.
Choosing Our Own Pathway to Competency-Based Undergraduate Medical Education
Authors: Veale Pamela , Busche Kevin , Touchie Claire , Coderre Sylvain , McLaughlin Kevin 
Published: August 2018

After many years in the making, an increasing number of postgraduate medical education (PGME) training programs in North America are now adopting a competency-based medical education (CBME) framework based on entrustable professional activities (EPAs) that, in turn, encompass a larger number of competencies and training milestones. Following the lead of PGME, CBME is now being incorporated into undergraduate medical education (UME) in an attempt to improve integration across the medical education continuum and to facilitate a smooth transition from clerkship to residency by ensuring that all graduates are ready for indirect supervision of required EPAs on day one of residency training. The Association of Faculties of Medicine of Canada recently finalized its list of 12 EPAs, which closely parallels the list of 13 EPAs published earlier by the Association of American Medical Colleges, and defines the “core” EPAs that are an expectation of all medical school graduates.
In this article, the authors focus on important, practical considerations for the transition to CBME that they feel have not been adequately addressed in the existing literature. They suggest that the transition to CBME should not threaten diversity in UME or require a major curricular upheaval. However, each UME program must make important decisions that will define its version of CBME, including which terminology to use when describing the construct being evaluated, which rating tools and raters to include in the assessment program, and how to make promotion decisions based on all of the available data on EPAs.
Professional Responsibilities and Personal Impacts: Residents’ Experiences as Participants in Education Research
Authors: Devine Luke A. , Ginsburg Shiphra , Stenfors Terese , Cil Tulin D. , McDonald-Blumer Heather , Walsh Catharine M. , Stroud Lynfa 
Published: August 2018

Purpose
Although the field of medical education research is growing and residents are increasingly recruited to participate as subjects in research studies, little is known about their experiences. The goal of this study was to explore the experiences and perceptions of residents who are study participants in medical education research.

Method
A phenomenographic approach was chosen to examine the range of residents’ experiences as research participants. A maximum variation sampling strategy was used to identify residents with diverse experiences. Semistructured interviews that explored experiences as research participants were conducted with 19 residents in internal medicine, general surgery, and pediatrics at the University of Toronto in 2015–2016.

Results
The perceptions and experiences of participants fell into two categories. First, participation was seen as a professional responsibility to advance the profession, including a desire to improve future educational practices and a sense of responsibility to contribute to the academic cause. Second, the experience was noted for its personal impact, including benefits (e.g., receiving monetary incentives or novel educational experiences) and risks (e.g., coercion and breaches of confidentiality). The time required to participate in a study was identified as one of the most important factors affecting willingness to participate and the impact of participation.

Conclusions
Being a participant in medical education research can be perceived in different ways. Understanding the view of resident participants is important to optimize potential benefits and minimize risks and negative consequences for them, thus fostering ready participation and high-quality research.