bluuebunny/crossref_metadata_2025_split huggingface dataset:
Levonorgestrel at emergency contraception dose has no effect on ciliary beat frequency and muscular contraction of the human fallopian tube: an in vitro experimental study
Authors: Li Raymond Hang Wun , Liao Su-Bin , Yeung William Shu Biu , Ng Ernest Hung Yu , O Wai Sum , Ho Pak Chung 
Published: November 2024

Abstract
Background
Levonorgestrel (LNG) acts as an emergency contraceptive mainly by inhibiting or postponing ovulation. We carried out this study to investigate whether LNG at concentration relevant for emergency contraception (EC) affect ciliary beat frequency and muscular contraction of the human Fallopian tube, which might contribute additional actions for EC.

Methods
This was an in vitro experimental study on human Fallopian tube tissue collected from ten women undergoing hysterectomy. The tubal explants were cultured in vitro, primed with oestradiol and progesterone at concentrations resembling the physiological early luteal phase, and treated with LNG at 0, 1, 10 and 100 ng/ml concentrations. Ciliary beat frequency was measured from the tubal epithelial strips, and the basal tone, amplitude and frequency of contractions were recorded from longitudinal smooth muscle strips. These parameters at different LNG concentrations were compared against the control (LNG 0 ng/ml).

Results
Treatment of tubal tissue strips with LNG at all concentrations studied did not significantly alter the ciliary beat frequency nor basal muscle tone (p > 0.05 for both) compared with control. Significant reduction in the amplitude and frequency of tubal muscular contractions was shown after treatment with LNG only at 100 ng/ml (p < 0.05 for both) but not lower concentrations (p > 0.05) compared with control.

Conclusion
LNG did not significantly inhibit ciliary beat frequency and muscular contraction of the human Fallopian tube at the doses used for EC, suggesting that the Fallopian tube is unlikely a target for the EC action of LNG.
Metabolomics and proteomics analyses of Chrysanthemi Flos: a mechanism study of changes in proteins and metabolites by processing methods
Authors: Zhang Wei , Qin Yu-wen , Ding Yang-fei , Xiong Jun-wei , Chang Xiang-wei , Zhao Hong-su , Xia Cheng-kai , Zhang Jiu-ba , Li Yu , Mao Chun-qin , Lu Tu-lin , Wu De-ling 
Published: November 2024

Abstract
Background
Chrysanthemi Flos is a traditional Chinese medicine with a long history of medicinal use. Prior research suggests that the intrinsic composition of Chrysanthemi Flos is affected by shade-drying and oven-drying methods. Nevertheless, the effects of these methods on the proteins and metabolites of Chrysanthemi Flos have not been extensively studied.

Methods
The TMT (tandem mass tag) quantitative proteomics method and the LC–MS/MS (liquid chromatography-tandem mass spectrometry) non-targeted metabolomics method were used to systematically study the differences in the proteins and metabolites during the process of drying Chrysanthemi Flos in the shade and an oven.

Results
Differentially accumulated metabolites and abundant proteins were primarily enriched in the purine metabolism, pyrimidine metabolism, cyanogenic amino acid metabolism, phenylpropanoid biosynthesis, and starch and sucrose metabolism pathways. Primary metabolites, such as guanine, xanthine, cytidine 5'-diphosphate serine, L-isoleucine, stearidonic acid, alginate, and inulin, play a crucial role in providing energy for Chrysanthemi Flos to withstand desiccation stress. The upregulation of ferulate-5- hydroxylase (F5H), shikimate O hydroxycinnamoyltransferase (HCT), caffeoyl-CoA O-methyltransferase (CCoAOMT), and chalcone isomerase (CHI) enzymes promotes the synthesis of flavonoids, including sinapic acid, caffeoyl shikimic acid, and naringenin chalcone, which possess antioxidant properties. Despite the notable improvements in energy metabolism and antioxidant capacity, these enhancements proved insufficient in halting the senescence and ultimate demise of Chrysanthemi Flos. Moreover, the shade-drying method can inhibit protein expression and promote the accumulation of bioactive components, but the drying efficiency is low, while the oven-drying method exhibits rapid drying efficiency, it does not effectively preserve the components.

Conclusion
Our study offers a comprehensive explanation for the changes in protein expression and metabolite conversion observed in shade-dried and oven-dried Chrysanthemi Flos, also providing a foundation for optimizing the drying process of Chrysanthemi Flos.
Electrical impedance tomography monitoring in adult ICU patients: state-of-the-art, recommendations for standardized acquisition, processing, and clinical use, and future directions
Authors: Scaramuzzo Gaetano , Pavlovsky Bertrand , Adler Andy , Baccinelli Walter , Bodor Dani L. , Damiani L. Felipe , Franchineau Guillaume , Francovich Juliette , Frerichs Inéz , Giralt Juan A. Sánchez , Grychtol Bartłomiej , He Huaiwu , Katira Bhushan H. , Koopman Alette A. , Leonhardt Steffen , Menga Luca S. , Mousa Amne , Pellegrini Mariangela , Piraino Thomas , Priani Paolo , Somhorst Peter , Spinelli Elena , Händel Claas , Suárez-Sipmann Fernando , Wisse Jantine J. , Becher Tobias , Jonkman Annemijn H. 
Published: November 2024

AbstractElectrical impedance tomography (EIT) is an emerging technology for the non-invasive monitoring of regional distribution of ventilation and perfusion, offering real-time and continuous data that can greatly enhance our understanding and management of various respiratory conditions and lung perfusion. Its application may be especially beneficial for critically ill mechanically ventilated patients. Despite its potential, clear evidence of clinical benefits is still lacking, in part due to a lack of standardization and transparent reporting, which is essential for ensuring reproducible research and enhancing the use of EIT for personalized mechanical ventilation. This report is the result of a four-day expert meeting where we aimed to promote the consistent and reliable use of EIT, facilitating its integration into both clinical practice and research, focusing on the adult intensive care patient. We discuss the state-of-the-art regarding EIT acquisition and processing, applications during controlled ventilation and spontaneous breathing, ventilation-perfusion assessment, and novel future directions.
Navigating crisis: exploring the links between threat perceptions, well-being, individual and workplace resilience among general hospital staff
Authors: Shmul Chen Sharon , Berzon Baruch , Adini Bruria 
Published: November 2024

Abstract
Background
Hospital staff frequently encounter high-stress situations, emergencies, and disasters, which profoundly impact their well-being and resilience. The aim of the study was to examine associations between perceived threats, well-being, individual resilience, and resilience at work among staff of a general hospital, following the unexpected Hamas assault on Israel on October 7, 2023, and during the Israel-Gaza conflict.

Methods
This cross-sectional study was conducted at a central Israeli public hospital, a level-two trauma center, surveying 434 staff members. Validated questionnaires were used to assess perceived threats, well-being, individual and work resilience, alongside demographic and professional characteristics. Data was collected via Qualtrics and paper questionnaires. Descriptive statistics, Pearson’s correlation, T-tests, ANOVA, Chi-square, and linear regression models were used to analyze relationships, differences, and key factors associated with well-being, personal resilience, and work resilience.

Results
Key findings revealed that higher resilience at work and well-being are linked to greater individual resilience, while higher threat perception negatively affected well-being. Israeli-born individuals and those identifying as Jewish showed higher resilience. Men reported higher well-being than women, and physicians demonstrated higher well-being compared to nurses. Resilience at work was higher among administrative staff compared to nurses, with employment in the emergency department showing a significant negative relationship with resilience at work.

Conclusions
The study revealed significant predictors of well-being, individual resilience, and workplace resilience among hospital staff in conflict situations. The immediate threat of war was perceived as most significant, highlighting the dynamic nature of threat perceptions. Prolonged emergencies can severely impact well-being, necessitating timely support. The findings emphasize the importance of integrated programs that enhance individual well-being and foster resilience in both personal and professional domains. Significant gender differences and the positive role of religiosity in resilience underscore the need for targeted interventions and systemic organizational changes to better support healthcare workers during crises. These insights highlight the importance of a comprehensive approach for cultivating a robust and resilient medical staff capable of effectively managing future crises.
Global surveillance of circulating microRNA for diagnostic and prognostic assessment of acute myocardial infarction based on the plasma small RNA sequencing
Authors: Wang Xiaomin , Lu Yaojun , Zhao Ruiping , Zhu Bing , Liu Jian , Yue Qiang , Wu Rina , Han Shuwen , Gao Yuanyuan , Chen Juan , Gong Jie , He Danna , Xu Teng , Ying Jianchao 
Published: November 2024

Abstract
Background
Circulating microRNAs (miRNAs) are recently a rapidly increasing of interest as non-invasive biomarkers for diagnosis and prognosis of acute myocardial infarction (AMI). Previous studies revealed that several miRNAs exhibited the capacity for diagnosis and prognosis of AMI, the reasons why these circulating miRNAs are concerned as targets for investigation are quite cryptogenic, presumably due to the lack of clues provided by global surveillance at the transcriptome level, and the current data for some miRNAs are controversial and inconsistent among independent studies.

Methods
To comprehensively profiling the potential miRNAs for diagnosis and prognosis of AMI, we reported transcriptomes of circulating miRNAs in the plasma of 27 healthy controls, 64 AMI patients (37 STEMI and 27 NSTEMI) and 20 AMI patients who were subjected to reperfusion therapy. Meanwhile, the cTnI of AMI patients was parallel determined. Differentially-circulated miRNAs were analyzed between each group. All detected circulating miRNAs were examined by ROC analysis and then LASSO dimension reduction to obtain an optimal panel for diagnosis of AMI. A five-year period follow-up towards the AMI and reperfusion patients was performed, and the prognostic value of circulating miRNAs in these patients was estimated by using the Cox regression model, ROC and Kaplan-Meier curves.

Results
Comprehensive global differences of miRNAs transcriptome among AMI, reperfusion patients and healthy controls were identified. A total of 40 miRNAs, called high diagnostic performance miRNAs, including several previous well-studied miRNAs with AUC greater than 0.85 were shown to discriminate AMI with healthy controls. In addition, 29 miRNAs were analyzed to be strongly correlated with the plasma cTnI level, of which 20 overlapped with high diagnostic performance miRNAs. These overlapped miRNAs are over-represented in the pathways which actually reflect the pathological cause of myocardial infarction, as well as the regulation of gene expression and energetic pathway of cellular response to hypoxia. Finally, two miRNAs were analyzed to be significantly correlated to all-cause mortality.

Conclusion
This is the first time to survey plasma miRNAs for the development of AMI diagnostic and prognostic biomarkers at the transcriptome level. A subset of miRNAs exhibited potential diagnostic and prognostic merits for AMI.
Integrating expert patients perspectives on the processes of engaging them in early medical education
Authors: Saif Jaimy , Mellor Duane , Rogers David , Stocker Claire 
Published: November 2024

AbstractIn the practice of healthcare, a new paradigm has emerged that perhaps challenges traditional notions of patient-clinician relationships. This shift involves recognising the invaluable role of expert patients, individuals who possess first-hand experience of life with their specific health conditions or chronic illnesses. These individuals have gained deep practical insights, knowledge, and coping strategies through their personal journeys. Modern healthcare practice focusing on individualised care necessitates that patients and their experiences become integral to the education of future healthcare professionals, from the start of their learning journeys, steering us toward more compassionate and person-centred approaches. This communication article underscores the importance of developing structured, coordinated programs that involve patients in curriculum design, implementation, and evaluation. By fostering authentic partnerships, medical education can create richer learning environments that promote compassionate care and better prepare future healthcare professionals. Ultimately, embracing patient perspectives as integral to the educational process is essential for improving healthcare delivery and outcomes.
International study to develop a patient-reported outcome measure to evaluate outcomes of gender-affirming care - the GENDER-Q
Authors: Kaur Manraj N. , Morrison Shane D. , Kennedy Shelby L. , van de Grift Tim C. , Højgaard Astrid , Jacobsen Amalie Lind , Johnson Natasha , Mullender Margriet G. , Poulsen Lotte , Satterwhite Thomas , Santucci Richard , Semple John , Rae Charlene , Savard Kinusan , Sørensen Jens Ahm , Young-Afat Danny , Pusic Andrea L. , Klassen Anne F. 
Published: November 2024

Abstract
Background
To meaningfully understand outcomes of gender-affirming care, patient-reported outcome measures (PROMs) that are grounded in what matters to individuals seeking care are urgently needed. The objective of this study was to develop a comprehensive PROM to assess outcomes of gender-affirming care in clinical practice, research, and quality initiatives (the GENDER-Q).

Methods
Internationally established guidelines for PROM development were used to create a field test version of the GENDER-Q. In-depth interviews were conducted from December 2018 to March 2020 with youth and adults aged 16 years and older who were seeking or had received gender-affirming care at outpatient clinics providing gender-affirming care located within tertiary care centers or communities in Canada, Denmark, the Netherlands or the US. Data were analyzed and used to develop a conceptual framework and an item pool, which was used to develop preliminary scales. Between February 2021 to November 2021, iterative feedback was sought from clinicians and patient participants on the scales and used to refine or develop new scales. The revised scales were pilot-tested using a crowd-sourcing platform between February 2022 and April 2022.

Results
Data from interviews with 84 participants (aged 34 ± 14 years) resulted in a conceptual framework of the GENDER-Q with 13 domains measuring health-related quality of life, sexual, urination, gender practices, voice, hair, face and neck, body, breasts, genital feminization, chest, genital masculinization, and experience of care. Preliminary versions of 44 scales were developed covering most concepts in the conceptual framework. Iterative feedback was obtained from clinician experts (4 to 37 experts per scale; response rate, 67%) and 7–14 patient participants (depending on scale). All scales were refined, and 15 new scales were developed, resulting in 55 scales in the field test version of the GENDER-Q. In total, 601 transgender and gender diverse (TGD) people (aged 25 ± 6 years) participated in the pilot field test and the data were used to make changes to the field test survey.

Conclusion
The GENDER-Q was developed using extensive input from TGD individuals and clinician experts and represents the most comprehensive set of independently functioning scales that are available to date. An international field test of the GENDER-Q was completed in 2024 and the GENDER-Q is available for use in patient care, clinical research and quality improvement efforts.
Possibilities and Limitations in Substituting anti-Drug Antibody Titers with Signal-to-Noise Ratios: A Comprehensive Comparison Using Two Clinical Trial Datasets of Adalimumab
Authors: Jang Dawon , Kim Jaeil , Jo Youngwon , Lee Hyuna , Go Ahra , Kim Jieun , Choi Soyoung 
Published: November 2024

Abstract
Immunogenicity assessment is vital in clinical trials and is measured through a multi-tiered approach (screening, confirmatory and titer assays). However, recent studies have suggested that titer results could be reported from ADA signal-to-noise ratios (S/N ratios=sample mean signal/negative control mean signal). More data analysis using two clinical trials of adalimumab: SB5-1003 (single-dose, healthy participants) and SB5-4001 (multiple-dose, interchangeability study, patients with plaque psoriasis), therefore, is indispensable whether substituting ADA S/N ratio as an alternative way of reporting titer results has no impact on interpretation on clinical outcome. In this study, we demonstrated that there is a strong correlation between S/N ratios and titers and no impact on overall PK results. Nonetheless, sub-analyses with time or adalimumab level showed a change in the regression between S/N ratios and titers, leading to different titer values from the same S/N ratio. These data demonstrate that S/N ratios may fully replace titers in limited circumstances such as a biosimilar study which goal is to prove equivalence between the originator and candidate product, but need a caution in other cases.

Graphical Abstract
Klimat religijny w diecezji pomezańskiej u schyłku XIV i w pierwszych dziesięcioleciach XV wieku
Authors: Kwiatkowski Stefan 
Published: November 2024

Z Wprowadzenia „Ustalenia S. Kwiatkowskiego zawarte w monografii Klimat religijny w diecezji pomezańskiej u schyłku XIV i w pierwszych dziesięcioleciach XV wieku nie utraciły swej wartości. Praca wciąż zachowuje metodologiczną świeżość, imponuje interdyscyplinarnym podejściem oraz szeroką podstawą źródłową. Zawarte tutaj konkluzje nie zdezaktualizowały się, a nowsza historiografia ‒ poprzez uwzględnianie nowych kategorii źródłowych i stawianie kolejnych pytań ‒ wzbogaca nakreślony obraz życia religijnego i duchowego mieszkańców Powiśla i Żuław. Dlatego w treść rozprawy ingerowaliśmy w niewielkim stopniu, gdyż wyszliśmy z założenia, że niniejsze wprowadzenie oraz posłowie prof. Mariana Dygo w wystarczającym stopniu spełnią rolę uzupełniającą i wyjaśniającą. Wszelkie uzupełnienia w przypisach oraz w bibliografii zostały zaznaczone w nawiasach kwadratowych. W nowym wydaniu zamieszczono również ilustrację przedstawiającą kartę z anonimowego traktatu z 1426 r. oraz dwie mapy pozwalające umiejscowić w przestrzeni geograficznej wywody Autora”.
Penalty or Reward? The Effect of Social Disincentives on Online Users’ Contributions
Authors: Shen Wenqi , Liu Yan (Lucy) , Wang Yun (Alicia) 
Published: November 2024

Existing research on online communities has primarily demonstrated that users are motivated by social rewards or social incentives such as positive social feedback and enhanced reputation. In contrast, this study examines how social penalties, or social disincentives, including negative social feedback and loss in reputation, influence online users’ voluntary contributions in the short and long term. We develop empirical models to investigate reviewers’ decisions on whether to contribute (i.e., review incidence decision) and how much to contribute (i.e., quality-adjusted review effort decision) over time. Using a state-space model, we capture the dynamics in reviewers’ latent review motivation that stems from both social incentives and social disincentives. Based on a unique data set from the Amazon review system, our analysis shows that, surprisingly, social disincentives increase reviewers’ motivations to contribute more frequently and devote more effort to contributions. Such effects prevail in both the short and long term. In addition, a reviewer’s real name identity and experience moderate the impact of social disincentives on a reviewer’s contribution decisions. We find that loss in reputation has more impact on less experienced reviewers and anonymous reviewers. Our policy simulation exercise suggests that not providing negative social feedback could diminish reviewers’ review propensity by 7.85% (2.39%) and review effort by 14.82% (4.50%) in the short term (long term). Not allowing reputation loss on a review site decreases reviewers’ review propensity by 2.82% (1.40%) and review effort by 7.52% (3.45%) in the short term (long term). This paper was accepted by Chris Forman, information systems. Supplemental Material: The online appendices and data files are available at https://doi.org/10.1287/mnsc.2021.01115 .
Circularly coherent vortex beams with coherence singularities in free-space propagation
Authors: Qi Rui , Shiri Arash , Gbur Greg 
Published: November 2024

Circularly coherent sources, which are perfectly coherent on any ring that
is concentric to the beam center, can preserve the spiral phase structures
of optical vortices on propagation, making them potentially useful for
free-space applications such as communications and remote sensing. In this
study, we theoretically examine circularly coherent vortex beams by
imposing circular coherence on Laguerre-Gaussian (LG) beams. The
second-order coherence properties and coherence singularities of these
circularly coherent vortex beams are investigated in free-space
propagation up to 3 km. We discuss the noteworthy features of such
beams, including self-focusing that arises due to the circular
coherence.
Islamische Theologie der Religionen. Eine Einführung und Bewertung
Authors: Mirsadri Saida 
Published: November 2024

Abstract
This article analyses the development of Islamic theology of religions in recent decades and classifies the various approaches into two main categories: exclusivism and pluralism. Furthermore, it argues that, in contrast to the historical Islamic tradition, which predominantly pursued a rather exclusivist approach, a theology of religions based exclusively on the Qurʾan offers significantly greater potential for an Islamic theology of pluralism.
The fractional Hopf differential and a weak formulation of stationarity for the half Dirichlet energy
Authors: Gaia Filippo 
Published: November 2024

Abstract
We obtain a weak formulation of the stationarity condition for the half Dirichlet energy, which can be expressed in terms of a fractional quantity, related to the trace of the Hopf differential of the harmonic extension of the original map. As an application we show that conformal harmonic maps from the disc are precisely the harmonic extensions of stationary points of the half Dirichlet energy on the circle. We also derive a Noether theorem and a Pohozaev identity for stationary points of the half Dirichlet energy.
Struwe’s global compactness and energy approximation of the critical Sobolev embedding in the Heisenberg group
Authors: Palatucci Giampiero , Piccinini Mirco , Temperini Letizia 
Published: November 2024

Abstract
We investigate some of the effects of the lack of compactness in the critical Folland–Stein–Sobolev embedding in very general (possible non-smooth) domains,
by proving via De Giorgi’s Γ-convergence techniques that optimal functions for a natural subcritical approximations of the Sobolev quotient concentrate energy at one point. In the second part of the paper, we try to restore the compactness by extending the celebrated Global Compactness result to the Heisenberg group via a completely different approach with respect to the original one by Struwe [M. Struwe,
A global compactness result for elliptic boundary value problems involving limiting nonlinearities,
Math. Z. 187 1984, 4, 511–517].