bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cooperative effects of sequential PGF2α and IL-1β on IL-6 and COX-2 expression in human myometrial cells
Authors: Leimert Kelycia B , Verstraeten Barbara S E , Messer Angela , Nemati Rojin , Blackadar Kayla , Fang Xin , Robertson Sarah A , Chemtob Sylvain , Olson David M 
Published: February 2019

AbstractThe change from the state of pregnancy to the state of parturition, which we call uterine transitioning, requires the actions of inflammatory mediators and results in an activated uterus capable of performing the physiology of labor. Interleukin (IL)-1β and prostaglandin (PG)F2α are two key mediators implicated in preparing the uterus for labor by regulating the expression of uterine activation proteins (UAPs) and proinflammatory cytokines and chemokines. To investigate this process, primary human myometrial smooth muscle cells (HMSMC) isolated from the lower segment of women undergoing elective cesarean sections at term (not in labor) were used to test the inflammatory cytokine and UAP outputs induced by PGF2α and IL-1β alone or in sequential combinations. PGF2α and IL-1β regulate mRNA abundance of the PGF2α receptor FP, the IL-1 receptor system, interleukin 6, and other UAPs (OXTR, COX2), driving positive feedback interactions to further amplify their own proinflammatory effects. Sequential stimulation of HMSMC by PGF2α and IL-1β in either order results in amplified upregulation of IL-6 and COX-2 mRNA and protein, compared to their effects individually. These profound increases were unique to myometrium and not observed with stimulation of human fetal membrane explants. These results suggest that PGF2α and IL-1β act cooperatively upstream in the birth cascade to maximize amplification of IL-6 and COX-2, to build inflammatory load and thereby promote uterine transition. Targeting PGF2α or IL-1β, their actions, or intermediates (e.g. IL-6) would be an effective therapeutic intervention for preterm birth prevention or delay.
The Role of Humour in the Social Care Professions: An Exploratory Study
Authors: Fogarty Molly , Elliot Dely Lazarte 
Published: February 2019

Abstract
Six social care professionals were recruited to take part in in-depth interviews that sought to explore their phenomenological experiences of humour within their place of work. Using an Interpretative Phenomenological Analysis (IPA) approach, the results suggest that humour serves various important functions within social care. Humour can allow social care professionals to relieve themselves of negative emotions, to avoid stress and cynicism, to achieve a sense of normality and perspective and to engage with service users. The positive impact humour appears to have upon these professionals is in keeping with the humour–health hypothesis, which posits that humour enhances well-being. However, results from this study also suggest that humour may be capable of negatively impacting well-being. Arguably, these findings highlight the need to extend the humour–health hypothesis and incorporate the negative effects humour can have upon well-being. Results also indicate that, if used appropriately, humour can be utilised to benefit work performance and service user outcomes. The findings of this research hold important implications for how humour may be understood and fostered in social care training, practice and policy.
Identification of long non-coding RNA HERC2P2 as a tumor suppressor in glioma
Authors: Yang Chao , Wang Lin , Sun Jia , Zhou Jun-hu , Tan Yan-li , Wang Yun-fei , You Hua , Wang Qi-xue , Kang Chun-sheng 
Published: February 2019

Abstract
Long non-coding RNAs (lncRNAs) have been reported to play important roles in glioma; however, most of them promote glioma progression. We constructed a competing endogenous (ceRNA) network based on the Chinese Glioma Genome Atlas dataset, and lncRNA hect domain and RLD 2 pseudogene 2 (HERC2P2) is the core of this network. Highly connected genes in the ceRNA network classified the glioma patients into three clusters with significantly different survival rates. The expression of HERC2P2 is positively correlated with survival and negatively correlated with clinical grade. Cell colony formation, Transwell and cell scratch tests were performed to evaluate the role of HERC2P2 in glioblastoma growth. Furthermore, we overexpressed HERC2P2 in U87 cells and established a mouse intracranial glioma model to examine the function of HERC2P2 in vivo. In conclusion, we identified a lncRNA with tumor suppressor functions in glioma that could be a potential biomarker for glioma patients.
Effect of antipsychotics on community structure in functional brain networks
Authors: Flanagan Ryan , Lacasa Lucas , Towlson Emma K , Lee Sang Hoon , Porter Mason A 
Published: February 2019

AbstractSchizophrenia, a mental disorder that is characterized by abnormal social behaviour and failure to distinguish one’s own thoughts and ideas from reality, has been associated with structural abnormalities in the architecture of functional brain networks. In this article, we (1) investigate whether mesoscale network properties give relevant information to distinguish groups of patients from controls in different scenarios and (2) use this lens to examine network effects of different antipsychotic treatments. Using various methods of network analysis, we examine the effect of two classical therapeutic antipsychotics—Aripiprazole and Sulpiride—on the architecture of functional brain networks of both controls (i.e., a set of people who were deemed to be healthy) and patients (who were diagnosed with schizophrenia). We compare community structures of functional brain networks of different individuals using mesoscopic response functions, which measure how community structure changes across different scales of a network. Our approach does a reasonably good job of distinguishing patients from controls, and the distinction is sharper for patients and controls who have been treated with Aripiprazole. Unexpectedly, we find that this increased separation between patients and controls is associated with a change in the control group, as the functional brain networks of the patient group appear to be predominantly unaffected by this drug. This suggests that Aripiprazole has a significant and measurable effect on community structure in healthy individuals but not in individuals who are diagnosed with schizophrenia, something that conflicts with the naive assumption that the drug alters the mesoscale network properties of the patients (rather than the controls). By contrast, we are less successful at separating the networks of patients from those of controls when the subjects have been given the drug Sulpiride. Taken together, in our results, we observe differences in the effects of the drugs (and a placebo) on community structure in patients and controls and also that this effect differs across groups. From a network-science perspective, we thereby demonstrate that different types of antipsychotic drugs selectively affect mesoscale properties of brain networks, providing support that structures such as communities are meaningful functional units in the brain.
Flight initiation distance, color and camouflage
Authors: Møller Anders Pape , Liang Wei , Samia Diogo S M 
Published: February 2019

AbstractCamouflage is widespread throughout the animal kingdom allowing individuals to avoid detection and hence save time and energy rather than escape from an approaching predator. Thus, camouflage is likely to have co-evolved with antipredator behavior. Here, we propose that camouflage results in dichotomous escape behavior within and among species with classes of individuals and species with cryptic coloration having shorter flight initiation distances (FIDs; the distance at which an individual takes flight when approached by a human). We report the results of 2 tests of this hypothesis. First, bird species with cryptically colored plumage have consistently shorter FID than closely related species without such color. Within species with sexually dimorphic plumage, brightly colored adult male common pheasants Phasianus colchicus and golden pheasants Chrysolophus pictus have long and variable FID, whereas cryptically colored juveniles and adult females have short and invariable FID. Second, FID in females was predicted by presence or absence of cryptic color, FID in males and their interaction. These findings are consistent with the hypothesis that risk-taking behavior has been attuned to camouflage, and that species with different levels of camouflage differ consistently in their FID.
Surgery for anomalous aortic origin of coronary arteries: a multicentre study from the European Congenital Heart Surgeons Association†
Authors: Padalino Massimo A , Franchetti Nicola , Hazekamp Mark , Sojak Vladimir , Carrel Thierry , Frigiola Alessandro , Lo Rito Mauro , Horer Jurgen , Roussin Regine , Cleuziou Julie , Meyns Bart , Fragata Jose , Telles Helena , Polimenakos Anastasios C , Francois Katrien , Veshti Altin , Salminen Jukka , Rocafort Alvaro Gonzalez , Nosal Matej , Vedovelli Luca , Guariento Alvise , Vida Vladimiro L , Sarris George E , Boccuzzo Giovanna , Stellin Giovanni 
Published: February 2019

Abstract

OBJECTIVES:
We sought to describe early and late outcomes in a large surgical series of patients with anomalous aortic origin of coronary arteries.

METHODS:
We performed a retrospective multicentre study including surgical patients with anomalous aortic origin of coronary arteries since 1991. Patients with isolated high coronary takeoff and associated major congenital heart disease were excluded.

RESULTS:
We collected 156 surgical patients (median age 39.5 years, interquartile range 15–53) affected by anomalous right (67.9%), anomalous left (22.4%) and other anatomical abnormalities (9.6%). An interarterial course occurred in 86.5%, an intramural course in 62.8% and symptoms in 85.9%. The operations included coronary unroofing (56.4%), reimplantation (19.2%), coronary bypass graft (15.4%) and other (9.0%). Two patients with preoperative cardiac failure died postoperatively (1.3%). All survivors were discharged home in good clinical condition. At a median follow-up of 2 years (interquartile range 1–5, 88.5% complete), there were 3 deaths (2.2%), 9 reinterventions in 8 patients (5 interventional, 3 surgical); 91.2% are in New York Heart Association functional class ≤ II, but symptoms persisted in 14.2%; 48.1% of them returned to sport activity. On Kaplan–Meier analysis, event-free survival at follow-up was 74.6%. Morbidity was not significantly different among age classes, anatomical variants and types of surgical procedures. Furthermore, return to sport activity was significantly higher in younger patients who participated in sports preoperatively.

CONCLUSIONS:
Surgical repair of anomalous aortic origin of coronary arteries is effective and has few complications. Unroofing and coronary reimplantation are safe and are the most common procedures. The occurrence of late adverse events is not negligible, and long-term surveillance is mandatory. Most young athletes can return to an unrestrained lifestyle.
Double orifice and atrioventricular septal defect: dealing with the zone of apposition†
Authors: Pontailler Margaux , Haidar Moussa , Méot Mathilde , Moreau de Bellaing Anne , Gaudin Régis , Houyel Lucile , Metton Olivier , Moceri Pamela , Bonnet Damien , Vouhé Pascal , Raisky Olivier 
Published: February 2019

AbstractOBJECTIVESA double orifice of the left atrioventricular valve (LAVV) associated with atrioventricular septal defects (AVSD) can significantly complicate surgical repair. This study reports our experience of AVSD repair over 3 decades, with special attention to the zone of apposition (ZoA) of the main orifice, and presents a technique of hemivalve pericardial extension in specific situations.METHODSWe performed a retrospective study from 1987 to 2016 on 1067 patients with AVSD of whom 43 (4%) had a double orifice, plus 2 additional patients who required LAVV pericardial enlargement. Median age at repair was 1.3 years. Mean follow-up was 8.2 years (1 month–32 years).RESULTSAssociated abnormalities of the LAVV subvalvular apparatus were found in 7 patients (5 parachute LAVV and 2 absence of LAVV subvalvular apparatus). ZoA was noted in 4 patients (9%): partially closed in 15 (35%) and completely closed in 24 (56%). Four patients required, either at first repair or secondarily, a hemivalve enlargement using a pericardial patch without closure of the ZoA. The early mortality rate was 7% (n = 3), all before 2000. Two patients had unbalanced ventricles and the third had a single papillary muscle. There were no late deaths. Six patients (14%) required 7 reoperations (3 early and 4 late reoperations) for LAVV regurgitation and/or dysfunction, of whom 4 (9%) required mechanical LAVV replacement (all before 2000). Freedom from late LAVV reoperation was 97% at 1 year, 94% at 5 years and 87% at 10, 20 and 30 years. Unbalanced ventricles (P = 0.045), subvalvular abnormalities (P = 0.0037) and grade >2 LAVV postoperative regurgitation (P = 0.017) were identified as risk factors for LAVV reoperations. Freedom from LAVV mechanical valve replacement was 95% at 1 year, 90% at 5 years and 85% at 10, 20 and 30 years. An anomalous LAVV subvalvular apparatus was identified as a risk factor for mechanical valve replacement (P = 0.010). None of the patients who underwent LAVV pericardial extension had significant LAVV regurgitation at the last follow-up examination.CONCLUSIONSRepair of AVSD and double orifice can be tricky. Preoperative LAVV regurgitation was not identified as an independent predictor of surgical outcome. LAVV hemivalve extension appears to be a useful and effective alternate surgical strategy when the ZoA cannot be closed.
Next Generation Strategies for Geroprotection via mTORC1 Inhibition
Authors: Dumas Sabrina N , Lamming Dudley W 
Published: February 2019

Abstract
Inhibition of mTORC1 (mechanistic Target Of Rapamycin Complex 1) with the pharmaceutical rapamycin prolongs the lifespan and healthspan of model organisms including rodents, with evidence now emerging that rapamycin and its analogs may also have rejuvenative effects in dogs and humans. However, the side effects associated with long-term rapamycin treatment, many of which are due to inhibition of a second mTOR complex, mTORC2, have seemed to preclude the routine use of rapamycin as a therapy for age-related diseases. Here, we discuss recent findings suggesting that strong, chronic inhibition of both mTOR complexes may not be necessary to realize the geroprotective effects of rapamycin. Instead, modestly but specifically inhibiting mTORC1 via a variety of emerging techniques, including intermittent or transient treatment with rapamycin derivatives, or specific dietary regimens, may be sufficient to promote health and longevity with reduced side effects. We will also discuss prospects for the development of new molecules that, by harnessing the detailed molecular understanding of mTORC1 signaling developed over the last decade, will provide new routes to the selective inhibition of mTORC1. We conclude that therapies based on the selective inhibition of mTORC1 may soon permit the safer treatment of diseases of aging.
Streptococcus Salivarius: A Potential Salivary Biomarker for Orofacial Granulomatosis and Crohn’s Disease?
Authors: Goel Rishi M , Prosdocimi Erica M , Amar Ariella , Omar Yasmin , Escudier Michael P , Sanderson Jeremy D , Wade William G , Prescott Natalie J 
Published: February 2019

AbstractBackgroundOrofacial granulomatosis (OFG) is a rare disease characterised by chronic, noncaseating, granulomatous inflammation primarily affecting the oral cavity. Histologically, it is similar to Crohn’s disease (CD), and a proportion of patients have both OFG and CD. The cause of OFG remains elusive, but it has been suggested that microbial interactions may be involved. The aim of this study was to compare the salivary microbial composition of subjects with OFG and/or CD and healthy controls.MethodsTwo hundred sixty-one subjects were recruited, of whom 78 had OFG only, 40 had both OFG and CD, 97 had CD only with no oral symptoms, and 46 were healthy controls. Bacterial community profiles were obtained by sequencing the V1-V3 region of the 16S rRNA gene.ResultsThere were no differences in richness or diversity of the salivary bacterial communities between patient groups and controls. The relative abundance of the Streptococcus salivarius group was raised in patients with OFG or CD only compared with controls, whereas that of the Streptococcus mitis group was lower in CD compared with both OFG and controls. One S. salivarius oligotype made the major contribution to the increased proportions seen in patients with OFG and CD.ConclusionsThe salivary microbiome of individuals with OFG and CD was similar to that found in health, although the proportions of S. salivarius, a common oral Streptococcus, were raised. One specific strain-level oligotype was found to be primarily responsible for the increased levels seen.
Is microwave ablation more effective than radiofrequency ablation in achieving local control for primary pulmonary malignancy?
Authors: Tsakok Maria Theresa , Jones Daniel , MacNeill Alice , Gleeson Fergus Vincent 
Published: February 2019

Abstract
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was ‘Is microwave ablation (MWA) more effective than radiofrequency ablation (RFA) in achieving local control for primary lung cancer?’. Altogether, 439 papers were found, of which 7 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Both are thermal ablative techniques, with microwave ablation (MWA) the newer technique and radiofrequency ablation (RFA) with a longer track record. Lack of consensus with regard to definitions of technical success and efficacy and heterogeneity of study inclusions limits studies for both. The only direct comparison study does not demonstrate a difference with either technique in achieving local control. The quality of evidence for MWA is very limited by retrospective nature and heterogeneity in technique, power settings and tumour type. Tumour size and late-stage cancer were shown to be associated with higher rates of local recurrence in 1 MWA study. RFA studies were generally of a higher level of evidence comprising prospective trials, systematic review and meta-analysis. The recurrence rates for MWA and RFA overlapped, and for the included studies ranged between 16% and 44% for MWA and 9% and 58% for RFA. The current evidence, therefore, does not clearly demonstrate a benefit of MWA over RFA in achieving local control in primary lung cancer.
Expanding Cone and Applications to Homogeneous Dynamics
Authors: Shi Ronggang 
Published: February 2019

Abstract
Let $U$ be a horospherical subgroup of a noncompact simple Lie group $H$ and let $A$ be a maximal split torus in the normalizer of $U$. We define the expanding cone $A_U^+$ in $A$ with respect to $U$ and show that it can be explicitly calculated. We prove several dynamical results for translations of $U$-slices by elements of $A_U^+$ on a finite volume homogeneous space $G/\Gamma $ where $G$ is a Lie group containing $H$. More precisely, we prove quantitative nonescape of mass and equidistribution of a $U$-slice. If $H$ is a normal subgroup of $G$ and the $H$ action on $G/\Gamma $ has a spectral gap, we prove effective multiple equidistribution and pointwise equidistribution with an error rate. In this paper, we formulate the notion of the expanding cone and prove the dynamical results above in the more general setting where $H$ is a semisimple Lie group without compact factors. In the appendix, joint with Rene Rühr, we prove a multiple ergodic theorem with an error rate.
Status, Stratified Rights, and Accommodation in International Relations
Authors: Ward Steven 
Published: February 2019

AbstractDenied status claims can produce serious interstate conflict and accommodation may thus be an important means of avoiding conflict with rising and reemerging status seekers such as China and Russia. But accommodation is an underdeveloped concept. This article draws on scholarship about recognition and hierarchy to propose a novel means of understanding status accommodation: as behavior that sends signals to status seekers about the validity of claims to stratified rights. This framework implies that acts that signal status denial (and thus cause conflict over status) may be driven by three broad kinds of processes: anxiety about a state's position in the world; incompatibility between nonstatus interests and claims to status-implicated rights; and fears about the implications of status accommodation for the validity of discourses and ideas that produce both international and domestic order. These dynamics—especially the latter two—may be linked to domestic political mechanisms and concerns in ways that analysts do not fully appreciate. I illustrate the framework by examining the forces that drove the United States to deny Japanese claims to equal status during the decades before World War II.
Optimizing Postoperative Surveillance of Pediatric Low-Grade Glioma Using Tumor Behavior Patterns
Authors: Zaazoue Mohamed A , Manley Peter E , Mehdar Mohammed Al , Ullrich Nicole J , Dasenbrock Hormuzdiyar H , Chordas Christine A , Goumnerova Liliana C 
Published: February 2019

Abstract

BACKGROUND
Pediatric low-grade gliomas are among the most common childhood neoplasms, yet their post-treatment surveillance remains nonstandardized, relying on arbitrarily chosen imaging intervals.

OBJECTIVE
To optimize postoperative magnetic resonance imaging (MRI) surveillance protocols for pediatric low-grade gliomas.

METHODS
Patients aged 0 to 21 yr with pediatric low-grade gliomas, treated between 1990 and 2016 were retrospectively analyzed. The timing of surveillance imaging and radiologic tumor outcomes were extracted, and the effect of patient age, tumor location, histology, and extent of resection as prognostic factors was studied. An algorithm was developed to analyze the detection efficacy and cost of all possible surveillance protocols.

RESULTS
A total of 517 patients were included with a median follow-up of 7.7 yr (range: 2-25.1 yr) who underwent 8061 MRI scans (mean 15.6 scans per patient). Tumor recurrence was detected radiologically in 292 patients (56.5%), of whom, 143 underwent reoperation. The hazards ratio (HR) of recurrence was higher in patients who underwent biopsy (HR = 3.60; 95% confidence interval (CI): 2.45-5.30; P < .001), subtotal resection (HR = 2.97; 95% CI: 2.18-4.03; P < .001), and near-total resection (HR = 2.03; 95% CI: 1.16-3.54; P = .01), compared to patients with gross total resection (GTR). For all patients, an 8-image surveillance protocol at 0, 3, 6, 12, 24, 36, 60, and 72 mo (total cost: $13 672 per patient) yielded comparative detection rates to the current 15-image protocol ($25 635). For patients who underwent GTR, a 6-image protocol at 0, 3, 9, 24, 36, and 60 mo ($10 254) is sufficient.

CONCLUSION
Our data suggest that postoperative surveillance of pediatric low-grade gliomas can be effectively performed using less frequent imaging compared to current practice, thereby improving adherence to follow-up, and quality-of-life, while reducing costs.