bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pipeline right‐of‐way construction activities impact on deep soil compaction
Authors: Tekeste Mehari Z. , Hanna Harold M. , Neideigh Erica R. , Guillemette Andrew 
Published: January 2019

AbstractA 762‐mm‐diameter pipe 1,886 km long was installed to transfer crude oil in the USA from North Dakota to Illinois. To investigate the impact of construction and restoration practices on long‐term soil productivity and crop yield, vertical soil stresses induced by a Caterpillar (CAT) pipe liner PL 87 (475 kN vehicle load) and semi‐trailer truck (8.9 kN axle load) were studied in a farm field. Soil properties (bulk density and cone penetration resistance) were measured on field zones within the right‐of‐way (ROW) classified according to construction machine trafficking and subsoil tillage (300‐mm‐depth tillage and 450‐mm‐depth tillage in two repeated passes) treatments. At 200 mm depth from the subsoiled surface, the magnitude of peak vertical soil stress from trafficking by the semi‐truck trailer and CAT pipe liner PL 87 was 133 kPa. The peak vertical soil stress at 400 mm soil depth appeared to be influenced by vehicle weight, where the Caterpillar pipe liner PL 87 created soil compaction a magnitude of 1.5 greater than from the semi‐trailer truck. Results from the soil bulk density and soil cone penetration resistance measurements also showed the ROW zones had significantly higher soil compaction than adjacent unaffected corn planted fields. Tillage to 450 mm depth alleviated the deep soil compaction better than the 300‐mm‐depth tillage as measured by soil cone penetration resistance within the ROW zones and the unaffected zone. These results could be incorporated into agricultural mitigation plans in ROW construction utilities to minimize soil and crop damage.
Changes in soil macropores: Superposition of the roles of organic nutrient amendments and the greenhouse pattern in vegetable plantations
Authors: Xu Lingying , Wang Meiyan , Tian Yutian , Shi Xuezheng , Shi Yijie , Yu Quanbo , Xu Shengxiang , Li Xiangwei , Xie Xinqiao 
Published: January 2019

AbstractOrganic farming can potentially mitigate soil compaction, which commonly occurs in vegetable plantations, particularly in greenhouses when compared with open‐air systems. Although several studies have addressed the effect of planting patterns on soil pore characteristics, few studies have focused on changes in pore attributes under organic fertilization. We used adjacent fields during green manure planting as a control to compare the differences in soil physicochemical and macropore parameters between 14‐year‐old greenhouse plots and open‐air plots under organic fertilization. Pearson's correlation analysis was performed to analyse the drivers of soil macropore characteristics in vegetable plantations in Jiangsu Province, China. A significant increase in connectivity, fractal dimensions and total macroporosity and a decrease in bulk density after 14 years of organic farming, particularly in the surface layer in the greenhouse, were observed. However, the difference in pores in the plough pan layer was not significant between the treatments. The volume of small pores (50–500 μm) and medium pores (500–1,000 μm) increased significantly (p < 0.05) in both the greenhouse and open‐air systems, showing significantly positive relationships with soil organic matter (SOM) and total nitrogen (TN) content. Large pores (>1,000 μm) showed a clear decrease, especially in open‐air fields, possibly due to the disappearance of the original straw residues in the surface layer. Small and medium pores in the plough layer increased in greenhouse fields, whereas the opposite occurred in open‐air fields. Overall, compared with open‐air systems, long‐term organic greenhouse patterns had a significantly positive effect on soil pore attributes.
Bronchoalveolar lavage hemosiderosis in dogs and cats with respiratory disease
Authors: Hooi Kimberly S. , Defarges Alice M. , Jelovcic Stipe V. , Bienzle Dorothee 
Published: January 2019

BackgroundHemosiderophages can be found in bronchoalveolar lavage samples and have been reported in association with a wide range of respiratory and cardiovascular disorders in cats and humans.ObjectivesThis study aimed to retrospectively evaluate the presence of hemosiderin in canine and feline bronchoalveolar lavage (BAL) samples. It also aimed to examine the association of BAL hemosiderin with signalment, clinical signs, and historical disease prior to BAL, with prior transthoracic fine‐needle aspiration (FNA), with bronchoalveolar lavage duration, and with cytologic interpretation.MethodsThe medical records of dogs and cats with respiratory disease that underwent BAL between 2007 and 2016 were reviewed. Appropriate medical information and BAL results were available from 171 dogs and 34 cats. Cases were assigned to four disease categories based on BAL cytologic findings: pneumonia, inflammatory disease, neoplasia, or normal airways. The degree of hemosiderosis was classified based on a semi‐quantitative scoring scale. Exact logistic regression analysis was used to evaluate the relationship between risk factors and the presence of BAL hemosiderosis on cytology.ResultsHemosiderin was identified in 13/171 (7.6%) canine samples and 18/34 (52.9%) feline samples. Cats were 13.33 times more likely to have pulmonary hemosiderosis on bronchoalveolar lavage cytology compared with dogs (P < 0.001). Increased respiratory rates, prolonged bronchoalveolar lavage times, concurrent transthoracic FNAs, and cytologic diagnoses were associated with an increased risk of hemosiderosis in dogs. No specific risk factors associated with pulmonary hemosiderosis in cats were identified.ConclusionsHemosiderosis is more common in BAL samples from cats than from dogs and is associated with a diverse range of disease conditions.
Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE): Domain 4—Refining and monitoring antithrombotic therapies
Authors: Sharp Claire R. , deLaforcade Armelle M. , Koenigshof Amy M. , Lynch Alex M. , Thomason John M. 
Published: January 2019

AbstractObjectivesTo systematically review the evidence for therapeutic monitoring of antithrombotic drugs in small animals, develop guidelines regarding antithrombotic monitoring, and identify knowledge gaps in the field.DesignFirst, a standardized, systematic literature review was conducted to address predefined PICO (Population/Patient, Intervention, Control, Outcome) questions, with categorization of relevant articles according to level of evidence and quality. Preliminary guidelines were developed by PICO worksheet authors and the domain chair. Thereafter, a Delphi‐style survey was used to develop consensus on guidelines regarding therapeutic monitoring of antithrombotics in dogs and cats.SettingAcademic and referral veterinary medical centers.ResultsPICO questions regarding the utility of therapeutic monitoring were developed for 6 different antithrombotic drugs or drug classes, including aspirin, clopidogrel, warfarin, unfractionated heparin, the low molecular weight heparins, and rivaroxaban, The majority of the literature pertaining to therapeutic monitoring of antithrombotic drugs was either performed in experimental animal models of disease or involved studies of drug pharmacokinetics and pharmacodynamics in healthy laboratory animals. There was a paucity of high level of evidence studies directly addressing the PICO questions, which limited the strength of recommendations that could be provided. The final guidelines recommend that therapeutic monitoring should be performed when using warfarin or unfractionated heparin in dogs and cats at risk of thrombosis. There is insufficient evidence to make strong recommendations for therapeutic monitoring of aspirin or low molecular weight heparin in dogs and cats at this time.ConclusionsAs in other CURATIVE domains, significant knowledge gaps were highlighted, indicating the need for substantial additional research in this field. Ongoing investigation of the role of therapeutic monitoring of antithrombotic therapies will undoubtedly facilitate improved outcomes for dogs and cats at risk of thrombosis.
Effects of Different Types Strength Exercises with Thera-Band® on Oxidative Stress and DNA Damage
Authors: Agirbas Ozturk 
Published: January 2019

The aim of this study is to determine the effects of both static and dynamic strength trainings on oxidative stress and DNA damage in elite boxers. 19 elite male boxers participated in the study. Boxers were instructed to perform strength exercises 3 days a week for 8 weeks. Blood samples were taken before exercises (resting), after the first exercise (acute) and after 8 weeks following the last exercise (chronic). MDA, SOD, GPx and 8-OHdG levels of blood were examined. Statistical analyses were carried out using the SPSS 22 for Windows. The data were found to not be distributed normally. Thus, Friedman, Wilcoxon and Mann-Whitney U tests were used. The results were evaluated using an alpha level of .05. In the dynamic strength exercise group, there was no significance at GPx, however MDA, SOD and 8-OHdG levels decreased in 8 weeks. In static strength exercise group, although there was no significance at SOD, GPx and 8-OHdG, MDA levels decreased both after a single session and in 8 weeks. In addition, significant difference was found between dynamic and static exercise groups at SOD, GPx and 8-OHdG levels in pre-exercise and at 8-OHdG levels after 8 weeks. Dynamic strength exercises with Thera-Band are effective on MDA, SOD and 8-OHdG chronically, static strength exercises are effective on MDA both acutely and chronically. Neither dynamic nor static strength exercises are not effective on GPx both acutely and chronically.
Estimation of impact of RPE65-mediated inherited retinal disease on quality of life and the potential benefits of gene therapy
Authors: Lloyd Andrew , Piglowska Natalia , Ciulla Thomas , Pitluck Sarah , Johnson Scott , Buessing Marric , O’Connell Thomas 
Published: January 2019

Background/aimsIn rare diseases, health-related quality of life (HRQL) data can be difficult to capture. Given the ultrarare nature of RPE65-mediated inherited retinal disease (IRD), it was not feasible to recruit a patient sample and collect HRQL data prospectively. The objectives of this study were to develop health state descriptions of RPE65-mediated IRD, and to estimate associated patient utilities.MethodsVignette descriptions of IRD states were developed and then assessed to elicit utilities. The vignettes ranged from moderate vision loss through to hand motion to no light perception (NLP). Six retina specialists with additional expertise in IRDs provided a proxy valuation of the vignettes using generic measures of health—the 5-level version of EQ-5D-5L and Health Utility Index 3 (HUI3). The data were then scored using standard methods for each instrument.ResultsWeights from both HRQL measures revealed a large decline in scores with vision loss. The EQ-5D-5L weights ranged from 0.709 for moderate vision loss to 0.152 for hand motion to NLP. The HUI3 weights ranged from 0.519 to − 0.039, respectively. A decline was seen on both measures, and the degree of decline from moderate vision loss to NLP was identical on both (−0.56).ConclusionThis is the first study to report HRQL weights (or utilities) for health states describing different levels of vision loss in patients with IRD, specifically those with RPE65-mediated disease. The parallel decline in scores from the EQ-5D and HUI3 corroborates the substantial impact of progressive vision loss on HRQL.
Normative pattern and determinants of outer retinal thickness in an Asian population: the Singapore Epidemiology of Eye Diseases Study
Authors: Dai Wei , Tham Yih-Chung , Chee Miao-Li , Majithia Shivani , Tan Nicholas Y Q , Wong Kah-Hie , Neelam Kumari , Cheung Ning , Sabanayagam Charumathi , Cheung Carol Y , Wong Tien-Yin , Cheng Ching-Yu 
Published: January 2019

Background/aimsTo evaluate the distribution and determinants of outer retinal thickness in eyes without retinal diseases, using spectral-domain optical coherence tomography (SD-OCT).MethodsParticipants were recruited from the Singapore Epidemiology of Eye Diseases Study, a population-based study among Chinese, Malays and Indians in Singapore. A total of 5333 participants underwent SD-OCT imaging in which a 6×6 mm2 measurement area centred at the fovea. Outer retinal thickness was defined as the distance from the outer plexiform layer to the retinal pigment epithelium layer boundary.Results7444 eyes from 4454 participants were included in final analysis. Of them, mean age was 58.4 years (SD 8.3), and 2294 (51.5%) were women. Women (121.0±8.1 µm) had thinner average outer retinal thickness than men (125.6±8.2 µm) (p<0.001). Malays (121.4±8.7 µm) had thinner average outer retinal thickness than Indians (124.3±8.6 µm) and Chinese (123.7±7.9 µm) (both p<0.001). In multivariable models, thinner average outer retinal thickness was associated with older age (per decade, β=−1.02, p<0.001), hypertension (β=−0.59, p=0.029), diabetes (β=−0.73, p=0.013), chronic kidney disease (β=−1.25, p=0.017), longer axial length (per mm, β=−0.76, p<0.001), flatter corneal curvature (per mm, β=−2.00, p<0.001) and higher signal strength (β=−1.46, p<0.001).ConclusionIn this large sample of Asian population, we provided normative SD-OCT data on outer retinal thickness in eyes without retinal diseases. Women had thinner outer retina than men. For the first time, these findings provide fundamental knowledge on normative profile of outer retinal thickness in Asians.
Association of visual acuity with educational outcomes: a prospective cohort study
Authors: Jan Catherine , Li Shi-Ming , Kang Meng-Tian , Liu Luoru , Li He , Jin Ling , Qin Xuezheng , Congdon Nathan , Wang Ningli 
Published: January 2019

Background/aimTo quantify the impact of baseline presenting visual acuity (VA), refractive error and spectacles wear on subsequent academic performance among Chinese middle school children.MethodsA prospective, longitudinal, school-based study on grade 7 Chinese children (age, mean±SD, 12.7±0.5 years, range=11.1–15.9) at four randomly selected middle schools in Anyang, China. Comprehensive eye examinations including cycloplegic autorefraction were performed at baseline, and information on demographic characteristics, known risk factors for myopia and spectacle wear was collected. Academic test scores for all subjects in the curriculum were obtained from the local Bureau of Education. Main outcome measure was total test scores for five subjects at the end of grade 9, adjusted for total scored at the beginning of grade 7.ResultsAmong 2363 eligible children, 73.1% (1728/2363) had seventh grade test scores available. 93.9% (1623/1728) completed eye examinations, and 98.5% (1599/1623) of these had ninth grade test scores. Adjusting only for baseline test score, the following were significantly associated with higher ninth grade scores: younger age, male sex, less time outdoors, better baseline presenting VA, higher parental education and income and parental myopia, but refractive error and spectacle wear were not. In the full multivariate model, baseline test score (p<0.001), presenting VA (p<0.01), age (p<0.001), quality of life (p<0.05) and parental education (p<0.001) and myopia (either: p<0.05; both: p<0.05) remained significantly associated with better ninth grade scores.ConclusionsIn this longitudinal study, better presenting VA, but not cycloplegic refractive error or spectacle wear, was significantly associated with subsequent academic performance.
Protocol for a feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients
Authors: Martin Daniel S , Brew-Graves Chris , McCartan Neil , Jell Gavin , Potyka Ingrid , Stevens Jia , Williams Norman R , McNeil Margaret , O’Driscoll B Ronan , Mythen Monty , Grocott Michael P W 
Published: January 2019

IntroductionOxygen is the most commonly administered drug to mechanically ventilated critically ill adults, yet little is known about the optimum oxygen saturation (SpO2) target for these patients; the current standard of care is an SpO2of 96% or above. Small pilot studies have demonstrated that permissive hypoxaemia (aiming for a lower SpO2than normal by using a lower fractional inspired oxygen concentration (FIO2)) can be achieved in the critically ill and appears to be safe. This approach has not been evaluated in a National Health Service setting. It is possible that permissive hypoxaemia may be beneficial to critically ill patients thus it requires robust evaluation.Methods and analysisTargeted OXygen therapY in Critical illness (TOXYC) is a feasibility randomised controlled trial (RCT) to evaluate whether recruiting patients to a study of permissive hypoxaemia is possible in the UK. It will also investigate biological mechanisms that may underlie the links between oxygenation and patient outcomes. Mechanically ventilated patients with respiratory failure will be recruited from critical care units at two sites and randomised (1:1 ratio) to an SpO2target of either 88%–92% or ≥96% while intubated with an endotracheal tube. Clinical teams can adjust FIO2and ventilator settings as they wish to achieve these targets. Clinical information will be collected before, during and after the intervention and blood samples taken to measure markers of systemic oxidative stress. The primary outcome of this study is feasibility, which will be assessed by recruitment rate, protocol adherence and withdrawal rates. Secondary outcomes will include a comparison of standard critical care outcome measures between the two intervention groups, and the measurement of biomarkers of systemic oxidative stress. The results will be used to calculate a sample size, likely number of sites and overall length of time required for a subsequent large multicentre RCT.Ethics and disseminationThis study was approved by the London - Harrow Research Ethics Committee on 2 November 2017 (REC Reference 17/LO/1334) and received HRA approval on 13 November 2017. Results from this study will be disseminated in peer-reviewed journals, at medical and scientific meetings, in the NIHR Journals Library and patient information websites.Trial registration numberNCT03287466; Pre-results.
Evaluation of the performance of nucleic acid amplification tests (NAATs) in detection of chlamydia and gonorrhoea infection in vaginal specimens relative to patient infection status: a systematic review
Authors: Rönn Minttu M , Mc Grath-Lone Louise , Davies Bethan , Wilson Janet D , Ward Helen 
Published: January 2019

ObjectiveWe evaluated the performance of nucleic acid amplification tests (NAATs) using vaginal specimens in comparison to specimens from the cervix or urine in their ability to detect chlamydia and gonorrhoea infection in women based on patient infection status (PIS).DesignSystematic review.Data sourcesEMBASE and Ovid MEDLINE databases were searched through 3 October 2017.Eligibility criteria for selecting studiesWe included studies that tested samples from the vagina and ≥1 other site (cervix and/or urine) with ≥2 NAATs for chlamydia and ≥2 NAATs or 1 NAAT and culture for gonorrhoea for each site.Data extraction and synthesisPerformance is defined as the sensitivity of a NAAT using a specimen site and PIS of the patient. We assessed risk of bias using modified QUADAS-2.ResultsNine publications met the inclusion criteria (eight for chlamydia; six for gonorrhoea) and were narratively reviewed. Pooled summary estimates were not calculated due to the variable methodology and PIS definitions. Tests performed on vaginal specimens accomplished similar performance to cervical and urine specimens for chlamydia (range of performance estimates: vaginal 65%–100%, cervical 59%–97%, urine 57%–100%) and gonorrhoea (vaginal 64%–100%, cervical 85%–100%, urine 67%–94%). Vaginal specimens were estimated to have a performance >80% for chlamydia and gonorrhoea infections in all but one study.ConclusionsPerformance of the NAATs for chlamydia and gonorrhoea detection using vaginal specimens was similar to that of cervical and urine specimens relative to PIS. As vaginal samples have a higher acceptability and lower cost, the study can support clinical testing guidelines by providing evidence that vaginal samples are a suitable alternative to traditionally used specimens.
Effect of work schedule on prospective antidepressant prescriptions in Sweden: a 2-year sex-stratified analysis using national drug registry data
Authors: Hall Amy L , Kecklund Göran , Leineweber Constanze , Tucker Philip 
Published: January 2019

IntroductionDepression-related mood disorders affect millions of people worldwide and contribute to substantial morbidity and disability, yet little is known about the effects of work scheduling on depression. This study used a large Swedish survey to prospectively examine the effects of work schedule on registry-based antidepressant prescriptions in females and males over a 2-year period.MethodsThe study was based on an approximately representative sample (n=3980 males, 4663 females) of gainfully employed participants in the Swedish Longitudinal Occupational Survey of Health. Sex-stratified analyses were conducted using logistic regression. For exposure, eight categories described work schedule in 2008: ‘regular days’ (three categories of night work history: none, ≤3 years, 4+ years), ‘night shift work’, ‘regular shift work (no nights)’, ‘rostered work (no nights)’, ‘flexible/non-regulated hours’ and ‘other’. For the primary outcome measure, all prescriptions coded N06A according to the Anatomical Therapeutic Chemical System were obtained from the Swedish National Prescribed Drug Register and dichotomised into ‘any’ or ‘no’ prescriptions between 2008 and 2010. Estimates were adjusted for potential sociodemographic, health and work confounders, and for prior depressive symptoms.ResultsIn 2008, 22% of females versus 19% of males worked outside of regular daytime schedule. Registered antidepressant prescription rates in the postsurvey period were 11.4% for females versus 5.8% for males. In fully adjusted models, females in ‘flexible/non-regulated’ schedules showed an increased OR for prospective antidepressant prescriptions (OR=2.01, 95% CI=1.08 to 3.76). In males, odds ratios were most increased in those working ‘other’ schedules (OR=1.72, 95% CI=0.75 to 3.94) and ‘Regular days with four or more years’ history of night work’ (OR=1.54, 95% CI=0.93 to 2.56).ConclusionsThis study’s findings support a relationship between work schedule and prospective antidepressant prescriptions in the Swedish workforce. Future research should continue to assess sex-stratified relationships, using detailed shift work exposure categories and objective registry data where possible.