bluuebunny/crossref_metadata_2025_split huggingface dataset:
Active recovery from concussion
Authors: Leddy John J. , Wilber Charles G. , Willer Barry S. 
Published: October 2018

Purpose of reviewRecent studies are challenging the utility of prolonged rest as treatment for concussion and postconcussion syndrome (PCS). The purpose of this paper is to review the evidence for active recovery from concussion and PCS.Recent findingsEmerging data identify the central role of autonomic nervous system (ANS) dysfunction in concussion pathophysiology. The exercise intolerance demonstrated by athletes after sport-related concussion may be related to abnormal ANS regulation of cerebral blood flow. As aerobic exercise training improves ANS function, sub-symptom threshold exercise treatment is potentially therapeutic for concussion. A systematic assessment of exercise tolerance using the Buffalo Concussion Treadmill Test has been safely employed to prescribe a progressive, individualized subthreshold aerobic exercise treatment program that can return patients to sport and work. Multiple studies are demonstrating the efficacy of an active approach to concussion management.SummarySustained rest from all activities after concussion, so-called ‘cocoon therapy’, is not beneficial to recovery. Evidence supports the safety, tolerability, and efficacy of controlled sub-symptom threshold aerobic exercise treatment for PCS patients. Further study should determine the efficacy and optimal timing, dose, and duration of subthreshold aerobic exercise treatment acutely after concussion because early intervention has potential to prevent PCS.
Fluctuating selection strength and intense male competition underlie variation and exaggeration of a water strider’s male weapon
Authors: Toubiana William , Khila Abderrahman 
Published: October 2018

AbstractSexually selected traits can reach high degrees of expression and variation under directional selection. A growing number of studies suggest that such selection can vary in space, time and form within and between populations. However, the impact of these fluctuations on sexual trait expression is poorly understood. The water striderMicrovelia longipesdisplays a striking case of exaggeration and phenotypic variation where males display extreme differences in the size of their rear legs. To study the origin and maintenance of this exaggerated trait, we conducted comparative behavioral and morphometric experiments in a sample ofMicroveliaspecies. We uncovered differences both in the mating behavior and the degree of sexual dimorphism across these species. Interestingly,M. longipesevolved a specific mating behavior where males compete for egg-laying sites, consisting of small floating objects, to intercept and copulate with gravid females. Field observations revealed rapid fluctuation inM. longipeshabitat stability and the abundance of egg-laying sites. Through male-male competition assays, we demonstrated that male rear legs are used as weapons to dominate egg-laying sites and that intense competition is associated with the evolution of rear leg length exaggeration. Paternity tests using genetic markers demonstrated that small males could only fertilize about 5% of the eggs when egg-laying sites are limiting, whereas this proportion increased to about 20% when egg-laying sites become abundant. Furthermore, diet manipulation and artificial selection experiments also showed that the exaggerated leg length inM. longipesmales is influenced by both genetic and nutritional factors. Collectively, our results highlight how fluctuation in the strength of directional sexual selection, through changes in the intensity of male competition, can drive the exaggeration and phenotypic variation in this weapon trait.
Regimes of Complex Lipid Bilayer Phases Induced by Cholesterol Concentration in MD Simulation
Authors: Pantelopulos George A. , Straub John E. 
Published: October 2018

AbstractCholesterol is essential to the formation of phase separated lipid domains in membranes. Lipid domains can exist in different thermodynamic phases depending on the molecular composition, and play significant roles in determining structure and function of membrane proteins. We investigate the role of cholesterol in the structure and dynamics of ternary lipid mixtures displaying phase separation using Molecular Dynamics simulations, employing a physiologically-relevant span of cholesterol concentration. We find that cholesterol can induce formation of three regimes of phase behavior, I) miscible liquid disordered bulk, II) phase separated, domain registered coexistence of liquid disordered and liquid ordered and domains, and III) phase separated, domain-anti-registered coexistence of liquid-disordered and newly-identified nanoscopic gel domains composed of cholesterol threads we name “cholesterolic gel” domains. These findings are validated and discussed in the context of current experimental knowledge, models of cholesterol spatial distributions, and models of ternary lipid mixture phase separation.
Tissue Fluidity Promotes Epithelial Wound Healing
Authors: Tetley Robert J. , Staddon Michael F. , Banerjee Shiladitya , Mao Yanlan 
Published: October 2018

SummaryEpithelial tissues are inevitably damaged from time to time and must therefore have robust repair mechanisms. The behaviour of tissues depends on their mechanical properties and those of the surrounding environment1. However, it remains poorly understood how tissue mechanics regulates wound healing, particularly inin vivoanimal tissues. Here we show that by tuning epithelial cell junctional tension, we can alter the rate of wound healing. We observe cells moving past each other at the wound edge by intercalating, like molecules in a fluid, resulting in seamless wound closure. Using a computational model, we counterintuitively predict that an increase in tissue fluidity, via a reduction in junctional tension, can accelerate the rate of wound healing. This is contrary to previous evidence that actomyosin tensile structures are important for wound closure2–6. When we experimentally reduce tissue tension, cells intercalate faster and wounds close in less time. The role we describe for tissue fluidity in wound healing, in addition to its known roles in developing7,8and mature tissues9, reinforces the importance of the fluid state of a tissue.
Forest quality, forest area and the importance of beta-diversity for protecting Borneo’s beetle biodiversity
Authors: Sharp Adam C. , Barclay Maxwell V. L. , Chung Arthur Y. C. , Rougemont Guillaume de , Turner Edgar C. , Ewers Robert M. 
Published: October 2018

SummaryThe lowland forest of Borneo is threatened by rapid logging for timber export and clearing for the expansion of timber and oil palm plantations. This combination of processes leaves behind landscapes dotted with small, often heavily-degraded forest fragments. The biodiversity value of such fragments, which are easily dismissed as worthless, is uncertain. We collected 187 taxa of rove beetles across a land-use gradient in Sabah, Malaysia, spanning pristine tropical lowland forest to heavily-degraded forest. Using these data, we identified shifts in alpha-, beta-, and gamma-diversity in response to forest quality and distance, then applied our findings from continuous expanses of forest to make predictions on hypothetical forest areas. We found that maintaining high forest quality is more important than forest area for conserving rare taxa (those important for conserving biodiversity per se), and that very small areas (10 ha) are likely to harbour the same richness of rove beetles as larger areas (100 ha) of equal forest quality. We estimate a decline in richness of 36% following heavy logging (removal of 95% of the vegetation biomass) from a forest area of 100 ha or less. Maintaining large forest area as well as high forest quality is important for conserving community composition, likely to be more important for conserving ecosystem functioning. We predict a decline of 35% in community diversity in conversion of a 100 ha area of unlogged forest to a 10 ha area of heavily-logged forest. Despite significant declines in alpha-diversity, beta-diversity within small rainforest areas may partially mitigate the loss of gamma-diversity, reinforcing the concept that beta-diversity is a dominant force determining the conservation of species in fragmented landscapes. In contrast to previous findings on larger animals, our results suggest that even small fragments of degraded forest might be important reservoirs of invertebrate biodiversity in tropical agriculture landscapes. These fragments, especially of lightly-logged forest, should be conserved where they occur and form an integral part of management for more sustainable agriculture in tropical landscapes.
Crystallographic and kinetic analyses of human IPMK reveal disordered domains modulate ATP binding and kinase activity
Authors: Seacrist Corey D. , Blind Raymond D. 
Published: October 2018

ABSTRACTInositol polyphosphate multikinase (IPMK) is a member of the IPK-superfamily of kinases, catalyzing phosphorylation of several soluble inositols and the signaling phospholipid PI(4,5)P2(PIP2). IPMK also has critical non-catalytic roles in p53, mTOR/Raptor, TRAF6 and AMPK signaling mediated partly by two disordered domains. Although IPMK non-catalytic functions are well established, it is less clear if the disordered domains are important for IPMK kinase activity or ATP binding. Here, kinetic and structural analyses of an engineered human IPMK lacking all disordered domains (ΔIPMK) are presented. Although theKMfor PIP2is identical between ΔIPMK and wild type, ΔIPMK has a 1.8-fold increase inkcatfor PIP2, indicating the native IPMK disordered domains decrease IPMK activityin vitro. The 2.5 Å crystal structure of ΔIPMK is reported, confirming the conserved ATP-grasp fold. A comparison with other IPK-superfamily structures revealed a putative “ATP-clamp” in the disordered N-terminus, we predicted would stabilize ATP binding. Consistent with this observation, removal of the ATP clamp sequence increases theKMfor ATP 4.9-fold, indicating the N-terminus enhances ATP binding to IPMK. Together, these structural and kinetic studies suggest in addition to mediating protein-protein interactions, the disordered domains of IPMK impart modulatory capacity to IPMK kinase activity through multiple kinetic mechanisms.
Striatal-frontal network activation during voluntary task selection under conditions of monetary reward
Authors: Orr Joseph M. , Imburgio Michael J. , Bernard Jessica A. , Banich Marie T. 
Published: October 2018

AbstractDuring voluntary task selection there are a number of internal and external biases that may guide such a choice. However, it is not well understood how reward influences task selection when multiple options are possible. To address this issue, we examined brain activation in a voluntary task-switching paradigm while participants underwent fMRI (n=19). To reinforce the overall goal to choose the tasks randomly, participants were told of a large bonus they would receive at the end of the experiment for making random task choices. We also examined how occasional, random rewards influenced both task performance and brain activation. We hypothesized that these transient rewards would increase the value of the just-performed task and therefore bias participants to choose to repeat the same task on the subsequent trial. Contrary to expectations, transient reward had no consistent behavioral effect on subsequent task choice. Nevertheless, the receipt of such rewards did influence activation in brain regions associated with reward processing as well as those associated with goal-directed control. In addition, reward on a prior trial was found to influence activation during task choice on a subsequent trial, with greater activation in a number of executive function regions as compared to no-reward trials. We posit that both the random presentation of transient rewards and the overall task bonus for random task choices together reinforced the goal to choose the tasks randomly, which in turn influenced activation in both reward-related regions and those regions involved in abstract goal processing.
Comparing faster evolving rplB and rpsC versus SSU rRNA for improved microbial community resolution
Authors: Guo Jiarong , Cole James R. , Brown C. Titus , Tiedje James M. 
Published: October 2018

AbstractMany conserved protein-coding core genes are single copy and evolve faster, and thus are more resolving phylogenetic markers than the standard SSU rRNA gene but their use has been precluded by the lack of universal primers. Recent advances in gene targeted assembly methods for large shotgun metagenomes make their use feasible. To evaluate this approach, we compared the variation of two single copy ribosomal protein genes, rplB and rpsC, with the SSU rRNA gene for all completed bacterial genomes in NCBI RefSeq. As expected, among pairwise comparisons of all species that belong to the same genus, 94.9% and 91.0% of the pairs of rplB and rpsC, respectively, showed more variation than did their SSU rRNA gene sequences. We used a gene-targeted assembler, Xander, to assemble rplB and rpsC from shotgun metagenomic data from rhizosphere samples of three crops: corn (annual), and Miscanthus and switchgrass (both perennials). Both protein-coding genes separated all three communities whereas the SSU rRNA gene could only separate the annual from the two perennial communities in ordination analyses. Furthermore, assembled rplB and rpsC yielded significantly higher numbers of OTUs (alpha diversity) than the SSU rRNA gene. These results confirm these faster evolving marker genes offer increased resolution of for comparative microbiome studies.
Joint analysis of simultaneous EEG and eye tracking data for video images
Authors: Szajerman Dominik , Napieralski Piotr , Lecointe Jean-Philippe 
Published: October 2018

Purpose
Technological innovation has made it possible to review how a film cues particular reactions on the part of the viewers. The purpose of this paper is to capture and interpret visual perception and attention by the simultaneous use of eye tracking and electroencephalography (EEG) technologies.

Design/methodology/approach
The authors have developed a method for joint analysis of EEG and eye tracking. To achieve this goal, an algorithm was implemented to capture and interpret visual perception and attention by the simultaneous use of eye tracking and EEG technologies. All parameters have been measured as a function of the relationship between the tested signals, which, in turn, allowed for a more accurate validation of hypotheses by appropriately selected calculations.

Findings
The results of this study revealed a coherence between EEG and eye tracking that are of particular relevance for human perception.

Practical implications
This paper endeavors both to capture and interpret visual perception and attention by the simultaneous use of eye tracking and EEG technologies. Eye tracking provides a powerful real-time measure of viewer region of interest. EEG technologies provides data regarding the viewer’s emotional states while watching the movie.

Originality/value
The approach in this paper is distinct from similar studies because it takes into account the integration of the eye tracking and EEG technologies. This paper provides a method for determining a fully functional video introspection system.
Levels and interconnections of project success in development projects by Non-Governmental Organisations (NGOs)
Authors: Nanthagopan Yogarajah , Williams Nigel , Thompson Karen 
Published: October 2018

Purpose
The purpose of this paper is to understand and identify the nature of evaluation criteria, levels and associations among levels of project success in development projects by NGOs in Sri Lanka.

Design/methodology/approach
The setting for this study is Sri Lanka, a country currently recovering from civil war and natural disasters and host to a large number of national and international NGOs involved in development projects. Data collection was conducted using a quantitative survey which obtained 447 responses. Multivariate analysis of data was conducted using confirmatory factor analysis and structural equation modelling.

Findings
The study confirmed that overall project success in NGOs could be assessed in three levels: project management (PM) success, project success and NGO success. The results conclude that there are strong associations among the three levels of project success; moreover, PM success and project success are indispensable for achieving NGO success.

Originality/value
This study extends existing research to confirm the presence of the three levels of project success and the interconnections among them. These findings can support subsequent research on development projects and also support the design of holistic evaluation tools to support project practices in NGOs.
Personality traits and expatriate adjustment in Malaysia
Authors: Richardson Christopher , Tan Guat-Hoon , Kiumarsi Shaian 
Published: October 2018

PurposeThis paper aims to investigate and reflect upon the effects of personality traits on expatriate adjustment within the context of Malaysia’s multicultural society.Design/methodology/approachDrawing on the multicultural personality questionnaire (MPQ) and extrapolating from the literature on expatriate adjustment, the authors introduce five hypotheses, which are then tested based on data derived from 101 expatriates working in Malaysia.FindingsThe results indicate a positive relationship between both open-mindedness and adjustment as well as between flexibility and adjustment. However, the authors did not observe any significant positive relationship between the three remaining MPQ personality traits and expatriate adjustment.Originality/valueWhile various studies have investigated the relationship between personality and expatriate adjustment in an Asian context, the majority have been conducted in largely monocultural settings, or at least on the implicit assumption of a single societal culture within the host country. This paper contributes to the literature by exploring the relationship in the context of a multicultural Asian host country.
Contextual variability in biopsychosocial pathways to violent offending
Authors: Fenimore Danielle M. , Jennings Wesley G. 
Published: October 2018

Purpose
The purpose of this paper is to use data from the Longitudinal Study of Violent Criminal Behavior in the USA to examine case configurations of violent behavior using a biopsychosocial framework. Specifically, the theory posits that arguably all behavior is the result of specific combinations of biopsychological (individual) and sociocultural (environmental) characteristics that are interacting within the individual. With regard to criminal and violent behavior, the theoretical assumption is that this maladaptive behavior is the result of a negative interaction between the biopsychological and sociocultural factors.

Design/methodology/approach
The study design consists of secondary data analysis. A conjunctive analysis of case configurations was performed using data from the Longitudinal Survey of Violent Criminal Behavior to formally explore the tenets of Cortés and Gatti’s (1972) biopsychosocial theory.

Findings
The results suggest that there are main effects for ego strength, family problems, family incohesiveness and underachievement as they relate to offending. A possible six-way interaction was also identified within the case configurations that provides empirical support for Cortés and Gatti’s (1972) biopsychosocial theory of deviance.

Originality/value
The present study contributes to the existing biopsychosocial literature by providing insight on the contextual variability in pathways to violent offending. Specifically, the evidence provided indicates that Cortés and Gatti’s (1972) biopsychosocial theory of deviance can be extended to comparing violent and non-violent offenders. Implications for policy and practice are also discussed.
Treatment of psychopathy: a conceptual and empirical review
Authors: Lewis Michael 
Published: October 2018

Purpose
For decades, psychopathy has been thought to be untreatable. Yet, conceptualisations, and indeed its assessment, have deviated away from viewing the disorder as personality pathology towards a behavioural focus where the core underlying deficits in cognition and affect have been ignored. Interventions have followed suit leading to a premature discounting of the role of therapy in adjusting psychopathic traits. The paper aims to discuss these issues.

Design/methodology/approach
The review critically evaluates the conceptual and empirical evidence relevant to the treatment of psychopathy, deciphering components integral to the disorder that require intervention. Psychopathy is approached from a developmental perspective, with the review identifying several mechanisms thought to be responsible for precipitating and perpetuating its expression.

Findings
There appears some utility in targeting psychopathy from multiple angles, addressing experiences of trauma, associated schemas and the underlying cognitive-affective dysfunction noted to give rise to psychopathic traits. A new model for treatment was proposed integrating these factors to encourage the design of effective interventions that will address the origins and underlying deficits of the disorder, rather than symptomology.

Originality/value
The review encourages future research to consider the aetiology of psychopathy, with the aim of informing early intervention and containing the disorder whilst in its infancy, as well as addressing neurobiological dysfunction when most malleable.