bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive Changes After Adjuvant Treatment in Older Adults with Early-Stage Breast Cancer
Authors: Lange Marie , Heutte Natacha , Noal Sabine , Rigal Olivier , Kurtz Jean-Emmanuel , Lévy Christelle , Allouache Djelila , Rieux Chantal , Lefel Johan , Clarisse Bénédicte , Leconte Alexandra , Veyret Corinne , Barthélémy Philippe , Longato Nadine , Tron Laure , Castel Hélène , Eustache Francis , Giffard Bénédicte , Joly Florence 
Published: June 2018

Abstract

Background
Group-based trajectory modeling is particularly important to identify subgroups of patients with pathological cognitive changes after cancer treatment. To date, only one study has explored cognitive trajectories in older patients with cancer. The present article describes objective cognitive changes before to after adjuvant treatment in older adults with early-stage breast cancer (EBC) after adjuvant treatment compared with healthy controls.

Patients and Methods
Participants were patients ≥65 years of age with newly diagnosed EBC and healthy controls (age-, sex-, and education-matched). The pretreatment assessment was conducted before adjuvant therapy, and the post-treatment assessment after the end of the first adjuvant treatment. Objective cognitive changes before to after treatment were evaluated based on the Reliable Change Index for cognitive decline accounting for cognitive impairment status.

Results
The sample consisted of women newly diagnosed with EBC (n = 118) and healthy controls (n = 62). Five patterns of changes before to after treatment were identified based on the presence of cognitive decline and cognitive impairment. The distribution of these five change patterns was statistically significant (p = .0001). Thirty-six percent of patients had phase shift changes, 31% without initial objective cognitive impairment developed impairment, 15% had a normal aging, 12% had a nonpathological decline, and 6% experienced accelerated cognitive decline.

Conclusion
This study described for the first time objective cognitive changes before to after treatment of older adults with EBC immediately after the end of adjuvant treatment. A longer-term remote follow-up of adjuvant treatment is needed to better understand the cognitive trajectories of older patients with EBC.

Implications for Practice
After the end of adjuvant treatment, 31% of older adults with early-stage breast cancer without initial objective cognitive impairment developed impairment, and 6% experienced accelerated cognitive decline. Initial cognitive functioning should be included in the balance of benefits and harms of systemic therapy for patients who are likely to be at highest risk for cognitive decline after cancer treatments. Regular cognitive follow-up of patients who had cognitive impairment before cancer treatment should monitor symptoms suggestive of neurodegenerative disease and avert the effect of cognitive disorders on patients’ autonomy.
Endocrine Therapy in Premenopausal Hormone Receptor Positive/Human Epidermal Growth Receptor 2 Negative Metastatic Breast Cancer: Between Guidelines and Literature
Authors: Tancredi Richard , Furlanetto Jenny , Loibl Sibylle 
Published: June 2018

Abstract

There is growing interest in the endocrine treatment (ET) of premenopausal women with hormone receptor positive (HR+) metastatic breast cancer (MBC). This review summarizes available data on endocrine therapy for this patient subset and aims to define the most appropriate treatment approach. The combination of luteinizing hormone-releasing hormone (LHRH) agonists plus tamoxifen seems effective and safe and is considered as being superior to either approach alone; still, single-agent therapy remains an acceptable treatment option. Due to their mechanism of action, aromatase inhibitors alone are not suitable for the treatment of premenopausal patients, but the combination with LHRH agonists may result in excellent disease control. Fulvestrant, in conjunction with LHRH agonists, also yields interesting results regarding clinical benefit rate and time to progression; currently, other orally available selective estrogen receptor downregulators are under clinical evaluation. Recently, targeted drugs have been added to ET in order to reverse endocrine resistance, but only limited information regarding their activity in premenopausal patients is available. The cyclin dependent kinase 4 and 6 inhibitor palbociclib when combined with fulvestrant and LHRH agonists was shown to prolong progression-free survival over endocrine therapy alone in pretreated patients; similar results were obtained with the addition of abemacicilib or ribociclib to endocrine therapy. Currently, activity of the mammalian target of rapamycin inhibitor everolimus in combination with letrozole and goserelin is under assessment in premenopausal patients after progression on tamoxifen (MIRACLE trial).

Implications for Practice
This review provides clinicians with an overview on the available data regarding endocrine treatment of hormone receptor positive (HR+) metastatic breast cancer (MBC) in premenopausal women and summarizes the treatment options available in routine clinical practice. Knowledge of an up-to-date therapeutic approach in women with premenopausal HR+ MBC will lead to better disease management, thereby improving disease control and quality of life while minimizing side effects.
ACTUAL PRACTICES IN DIAGNOSIS AND TREATMENT OF VENOUS DISEASES BY USING VEINVIEWER
Authors: TUNÇAY Aydın 
Published: June 2018

Objective:Veinviewer visualize peripheral vessels localized 8-10 mm deep under skin. This device can be used as a novel diagnostic and therapeutic assistant which provides chronoprofilaxy, cost reduction and comfort for patient and clinician. Thus, a prospective and randomized study was designed to assess versatility of Veinviewer in various applications.Method:The study included overall 40 patients who referred to outpatient clinic. Group 1 patients underwent sclerotherapy with or without using Veinviewer. Group 2 patients underwent phlebectomy with or without using Veinviewer.Results:It was seen that duration of the process was significantly reduced; and easiness of the process and patient quality of life were improved in the patients who underwent sclerotherapy via using Veinviewer(p&lt;0.05).It was found that duration of the phlebectomy was significantly reduced; and convenience in the process of finding and removal of varicose vein were improved in the patients who underwent surgical varicose vein excision via using Veinviewer(p&lt;0.05).Conclusion: It was detected that use of Veinviewer in sclerotherapy and phelebectomy, improved the comfort of patient and clinician, provided shorter and easier procedure and markedly contributed to effectiveness of therapy.
PERCEPCIONES SOBRE LAS COMPETENCIAS DE FORMACIÓN BÁSICA EN EDUCACIÓN INFANTIL
Authors: Martínez Sánchez Antonio 
Published: June 2018

El plan de estudios del Grado en Educación Infantil se ha transformado debido a la implementación del Espacio Europeo de Educación Superior, permitiendo desarrollar competencias para atender las necesidades formativas de los docentes. Este estudio analiza la valoración de las competencias de formación básica propuestas en el Grado de Educación Infantil tanto en el ámbito de la formación inicial de los estudiantes, como desde la óptica de los egresados de la titulación. Los instrumentos empleados han sido un cuestionario, se han analizado las opiniones de 50 estudiantes y 66 egresados, y entrevistas semiestructuradas. Para el análisis de los datos cuantitativos se ha utilizado el programa SPPS V.19, mientras que para los datos cualitativos se ha procedido a la codificación e integración de la información extraída de las entrevistas. Los resultados muestran que la mayoría de los participantes opinan favorablemente sobre las competencias analizadas, no existiendo diferencias significativas entre ambos colectivos.
ESTRATEGIAS EDUCATIVAS PARA LA INTEGRACIÓN DE LOS PADRES Y REPRESENTANTES EN EL PROCESO DE ENSEÑANZA APRENDIZAJE
Authors: Vegas Lameda Verónica R. , Guerrero Mirla M. , Gómez Jesús 
Published: June 2018

El presente estudio, se centró en desarrollar estrategias educativas para la integración de los padres y representantes en el proceso de enseñanza aprendizaje, en la Unidad Educativa Bolivariana “Samuel Robinson”, del Estado Barinas, Venezuela. La investigacion fue de naturaleza cualitativa, en la modalidad de investigación acción participante. La información fue analizada por medio de técnicas cualitativas descomponiendo en unidades de análisis, categorías y subcategorías, pudiéndose evidenciar la carencia de integración de los padres y representantes en el proceso de enseñanza aprendizaje de sus hijos, así como la falta de estrategias educativas pertinentes para la integración por parte de la institución. En atención a estos resultados, se procedió a planificar y ejecutar una serie de actividades con la participación activa de docentes, padres, representantes y estudiantes que permitieran vivenciar a estos actores sociales experiencias conjuntas de enseñanza y aprendizaje, lográndose un impacto positivo y transformador en este grupo social.
EL VALOR DE EDUCAR BIEN. PROMOVIENDO EL RESPETO DENTRO DEL AULA
Authors: Hernández Mendez Griselda 
Published: June 2018

El tema general que se aborda versa en torno a los valores. Se trata de una investigación de carácter aplicativo, la cual surgió del problema detectado por profesoras de preescolar acerca del comportamiento de los niños, como desatención de reglas, egoísmo, agresiones, arrebatos, entre otros; lo cual las llevó a suponer que los niños ingresan al preescolar sin valores. Algunas de ellas optaron por imponer su autoridad mediante estrategias de control. Sin embargo, una de ellas, junto con la autora del presente artículo, buscamos más que salves a este problema. Nos replanteamos como hipótesis que, mediante el uso de determinadas estrategias didácticas, se pueden desarrollar y fortalecer los valores en los niños, sin desatender los contenidos del plan de estudios de preescolar. Así, construimos una propuesta sustentándola en las bases del constructivismo y en varios aportes de la psicología: cognitiva, humanista y psicoanalítica, así como la teoría de los valores desde lo social-humanista. El objetivo principal fue desarrollar, de inicio, el valor respeto. La propuesta fue aplicada durante seis meses al grupo B de segundo grado y, para validar su alcance, implementamos el proceder de los estudios cuasi-experimentales. Medimos los resultados y los comparamos con el diagnóstico inicial realizado sobre el valor respeto de los niños. Se encontró un incremento significativo de indicadores del respeto, por lo que concluimos que se lograron los objetivos de la investigación y que la propuesta puede ser implementada en otras aulas de preescolar o incluso de primaria, con algunas variantes.
PUBLICIDAD SOCIAL Y APRENDIZAJE SERVICIO. UNA EXPERIENCIA COMPARTIDA
Authors: Rodrigo Martín Luis , Rodrigo Martín Isabel 
Published: June 2018

De todos es sabido que la publicidad social cumple una función educativa en la sociedad, comunicando y persuadiendo a los individuos hacia comportamientos de interés común. Por otro lado, la Educación, como institución encargada de formar ciudadanos responsables, críticos y democráticos, debe utilizar metodologías creativas y participativas en los procesos de enseñanza/aprendizaje para construir espacios de aprendizaje colectivo y aprendizajes significativos que caminen a favor del progreso social.Así la publicidad social, con sus mensajes publicitarios y el aprendizaje servicio se constituyen en herramientas útiles para la transformación de la sociedad. Los anuncios publicitarios y los contenidos curriculares pueden ser de utilidad para algunos alumnos o colectivos sociales a los que se les presta un servicio con finalidad social.
Reflexiones sobre la atención de los menores con trastorno de espectro autista en los centros educativos
Authors: Cortés Moreno Javier , Sotomayor Morales Eva María , Pastor Seller Enrique 
Published: June 2018

En el ámbito educativo, la inserción de los/as menores con Trastorno de Espectro Autista (TEA) en condiciones óptimas de inclusión resulta, con frecuencia, una tarea compleja. ¿Cuentan los centros educativos con una infraestructura sólida de recursos y de herramientas inclusivas?¿Disponen de profesionales competentes y especializados en la atención del alumnado con discapacidad?. El presente artículo, pretende responder a estas cuestiones y tiene como objetivo conocer la opinión de expertos/as en TEA sobre la situación y atención que reciben estos/as menores en los centros educativos. Entre las variables analizadas están las tipologías de los centros, las modalidades del Sistema Educativo Español, las herramientas y métodos de inclusión y el rol de los actores de la comunidad educativa (familiares, menores, equipos de orientación educativa, profesorado, profesionales especializados, etc.). La metodología que se ha empleado ha sido cualitativa, extrayendo los datos mediante la realización de dos grupos de discusión en la provincia de Jaén y en Salamanca. La muestra, se ha establecido mediante muestreo intencional, siendo los/as participantes diez profesionales expertos/as en TEA de distintas disciplinas (educación, psicología, trabajo social, terapia ocupacional, logopedia, audición y lenguaje). Todos/as los/as profesionales coinciden como principal resultado que resulta insuficiente la atención especializada que ofrecen los centros escolares, por lo que los/as menores deben complementarla con el apoyo externo del ámbito privado y/o de las asociaciones. De todo ello, se puede concluir que es necesario ampliar la plantilla de profesionales en los centros educativos, así como su formación y especialización en TEA.
LEGAL PROTECTION OF THE RIGHTS OF OLDER PERSONS AGAINST AGEISM
Authors: Munuera Gómez M. Pilar , Blanco Larrieux M. Elena 
Published: June 2018

Human beings go through stages of vulnerability during their evolution and development. Old age is one of these. The rights of older persons are acknowledged to a certain degree but have not yet been developed into an integral system like the rights of other groups, for instance the handicapped, have. Spanish legislation contemplates the rights of older persons to guarantee their social protection. The objective of this paper is to reveal the need of a single unified law to guarantee these rights. For this purpose, existing Spanish legislation has been reviewed, finding the underlying principles of this protection is based in the 1948 Universal Declaration of Human Rights. In current times older persons have ceased to be respected by their age and social position and sometimes find themselves socially excluded or legally unprotected. This circumstance claims a solution to avoid illtreatment. It calls for an institutional solution: the drafting of a charter of rights of the older person which would avoid behaviours that disregard this group, harming their dignity as individuals. It is difficult for older persons to gain respect for their participation as citizens because their social conditions are not equal to that of the rest of citizens who are allowed to make their rights effective and thus ensure their respect.
A cross sectional study of fasting and post prandial insulin level as a predictor of insulin resistance with hyperinsulinemia with HOMA-IR >2.5 among overweight and obese prepubertal children in a tertiary care Hospital of Bangalore, India
Authors: K. R. Sujith , H. Kiran Raj 
Published: June 2018

Background: Overweight and obesity has reached epidemic proportions in developed countries and is rapidly increasing. The proportion of children in the general population who are overweight and obese has doubled over the past two decades in developed and developing countries including India and have a rising prevalence of diabetes. Insulin resistance if detected early, we can intervene early to slow or halt the progression of the associated co morbidities. Dynamic phase of juvenile obesity is initially characterized by an abnormal postprandial profile of plasma insulin, even when fasting insulin levels are still normal and insulin sensitivity is slightly increased. Objective of present study was to find out the occurrence of hyperinsulinemia and Insulin Resistance Markers among overweight and obese children between 7 to 11 years.Methods: A cross sectional study was carried out in the Bangalore Baptist Hospital, Hebbal, Bangalore from September 2013 to May 2014. Children in the age group of 7 to 11 years who are overweight or obese admitted in the as per WHO Growth Charts were included in the study.A total of 51 Cases were included.Results: In present study the 21 (41.2%) of the study subjects were classified as Overweight and 30 (58.8%) were Obese. The association between level of HOMA-IR and the study variables like age, weight, Height, BMI, FBS, PPBS were found to not significant statistically with p value being more than 0.5. The Pearson Corelation between HOMA-IR and Fasting Blood Glucose, Post Prandial Blood Glucose level, Fasting Basal Insulin Level and Post Prandial Basal Insulin Level were found to statistically significant.Conclusions: Hyperinsulinism and insulin resistance is a concern not only in obese but also in overweight children as shown by the occurrence of insulin resistance.
A study to analyze the correlation between nutritional dermatoses with socioeconomic status, dietary fallacies and growth in children 1 to 5 years of age, in and around rural area
Authors: Kumar D. Pavan 
Published: June 2018

Background: Little information is available about the prevalence of skin conditions among the children in general population. Skin conditions vary in frequencies and severity in different age groups, different geographical locations and under different definitions of skin diseases. Low socioeconomic status, malnutrition, overcrowding, poor standards of hygiene are important factors accounting for development of nutritional dermatoses in developing countries such as India. The objective of the present research was to study the association between nutritional dermatoses with Socioeconomic status, dietary fallacies and growth in children 1 to 5 years of age. Methods: A cross sectional study was conducted in a rural based medical college of Dakshina Kannada District in Karnataka among the one to five years age children, who were attending the Pediatric out patient with nutritional skin lesions from the month of November 2012 to October 2013. The sample size was estimated as 150 children.Results: In present study, 76.00% (114) of children fall in the group of under nutrition and 73.33% (110) children is having the causative factor as Dietary Fallacies. Majority of children 60.66% (91) with nutritional dermatoses belongs to class IV socio-economic status according to B.G Prasad classification, 27.33% (41) belongs to class III and 12.00% (18) children belongs to class V. 64.66% (97) of children with nutritional dermatoses were underweight, 47.33% (71) of children showed wasting and 35.30% (53) children were stunted.Conclusions: Lower socioeconomic condition and dietary fallacies were the two most causative factors which had an adverse effect on nutritional status of child causing dermatoses. Nutrition deficiency had an impact of early transitional growth failure and delay in the achieving mile stone.
Prevalence of risk factors for non-communicable diseases among adult population in district Amritsar of Punjab
Authors: Gill Kanwal Preet Kaur , Devgun Priyanka , Mahajan Shyam Lal , Kaur Harpreet 
Published: June 2018

Background: The burden of chronic non-communicable diseases (NCDs) is rising rapidly all over the world. World Health Organization recommends surveillance of risk factors in different countries so that appropriate intervention is implemented to cut down the morbidity and mortality from NCDs. Hence, the presented study was planned with the objective of assessing the prevalence of common modifiable risk factors for NCDs in district Amritsar of Punjab.Methods: The study was conducted in Urban Health Training Centre of Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar. Sample size of 400 was calculated by adopting WHO Stepwise approach to surveillance guidelines. Behavioural risk factors, physical measurements and biochemical measurements were studied. Data was collected, compiled and analyzed by using SPSS 19.0 for windows evaluation version. Results: Majority of study subjects (98.75%) were taking inadequate vegetable and fruit servings irrespective of their age, gender, place of residence and educational status. The prevalence of physical exercise was also very low with only 86 (21.5%) of study subjects doing minimum recommended physical exercise. Among men, 27% of them were drinking alcohol, but among women, there was only one. Prevalence of smoking was very low (1.5%). Nearly one third (30.7%) of study subjects were overweight, 13.3% were obese, 35.3% were hyperglycemic and 36.7% were hypertensive. The prevalence of all these risk factors was found to be higher in higher age group.Conclusions: Low physical activity coupled with poor fruits and vegetables intake and alcohol consumption along with high prevalence of obesity, diabetes and hypertension is worrisome and needs to be addressed effectively.
Membran Blend Kitosan/Poli Vinil Alkohol (PVA): Pengaruh Komposisi material blend, pH, dan Konsentrasi bahan Pengikat Silang
Authors: Piluharto Bambang , Sjaifullah A , Rahmawati I , Nurharianto Erix 
Published: June 2018

AbstrakMembran blend biodegradabel dengan kestabilan termal dan mekanik yang berasal dari gabungan kitosan dan PVA telah dihasilkan melalui dua tahapan. Pada tahap pertama dilakukan proses pelarutan kitosan dan poli vinil alkohol dan selanjutnya pencampuran kitosan/PVA dan asam oksalat sebagai agen pengikat silang. Asam asetat dan air dipilih sebagai pelarut untuk kitosan dan PVA. Beberapa variasi dalam proses seperti perbandingan konsentrasi kitosan:PVA, konsentrasi agen pengikat silang dan pH buffer, dijadikan sebagai parameter pada penelitian ini. Kerapatan hidrogel dan kuat tarik mengalami kenaikan seiring dengan peningkatan konsentrasi agen pengikat silang dan PVA dengan konsentrasi kitosan paling rendah. Namun derajat swelling memiliki trend yang berbeda dimana naiknya derajat swelling diperoleh seiring dengan peningkatan konsentrasi kitosan dengan kondisi konsentrasi agen pengikat silang dan PVA paling rendah. Keberhasilan proses blending dan ikat silang ditunjukkan dari hasil spektra infra merah dimana analisa spektrum infra merah dari hidrogel kitosan murni dan hidrogel kitosan/PVA menunjukkan kenaikan intensitas serapan pada daerah amida (1600 cm-1 sampai 1670 cm-1), hal ini menguatkan dugaan terbentuknya ikatan silang antara asam oksalat sebagai crosslinker dengan kitosan. Kata kunci: membran blend, kitosan/PVA, asam oksalat, pengikat silang. AbstractBiodegradable blend membranes with thermal and mechanical stability based on combination of chitosan and PVA have been produced through two stages. In the first stage, chitosan and PVA are dissolved and further mixing chitosan/polyvinyl alcohol with oxalic acid as crosslinking agents. Acetic acid and water are selected as solvents for chitosan and PVA. Some variations in the process such as comparison of chitosan:PVA concentration, concentration of crosslinking agent and pH of buffer, are used as parameters in this study. The hydrogel density and tensile strength increased with increasing concentration of crosslinking agent and PVA with the lowest concentration of chitosan. However, the degree of swelling has a distinct trend in which the increase of degree of swelling is obtained along with the increase of chitosan concentration with the lowest concentration of crosslinking agent and PVA. The success of the blending and crosslinking process is shown by the results of infrared spectra where infrared spectrum analyzes from purified chitosan hydrogels and chitosan/chloride hydrogels show an increase in absorption intensity in the amide area (1600 cm-1 to 1670 cm-1), this reinforces the alleged crosslinking formation between oxalic acid as crosslinker and chitosan. Keywords: blend membrane, chitosan: PVA, crosslinker.