bluuebunny/crossref_metadata_2025_split huggingface dataset:
A decade of iron overload disorders and hemochromatosis: clinical and genetic findings from a specialized center in Colombia
Authors: Cristancho L. C. Quiroga , Urbano María Alejandra , Nati-Castillo H. A. , Obando María Alejandra , Gómez-Gutiérrez Rigoberto , Izquierdo-Condoy Juan S. 
Published: December 2024

BackgroundIron overload disorders, including hereditary hemochromatosis (HH), are characterized by excessive iron accumulation, which can cause severe organ damage. HH is most associated with the C282Y mutation in Caucasian populations, but its prevalence and genetic profiles in Latin American populations remain underexplored.ObjectivesTo describe the clinical manifestations, genetic profiles, and biochemical characteristics of patients with suspected iron overload disorders in a specialized hematology center in Cali, Colombia.MethodsA retrospective observational study was conducted on 70 patients diagnosed with iron overload disorders between 2014 and 2024. Data on clinical presentation, laboratory results, imaging, and genetic mutations were collected. Statistical analyses, including chi-square tests and logistic regression, were used to evaluate factors associated with HH diagnosis.ResultsMale patients constituted 64.3% of the sample, with a mean age of 56.1 years at diagnosis. Fatigue (27.1%) and joint pain (17.1%) were the most common symptoms. Of the total sample, 32.9% were diagnosed with hemochromatosis. The H63D mutation was the most prevalent (52.2%), while the C282Y mutation was rare. A predominance of both slight (100.0%) and limitrophe (58.3%) iron overload was identified among patients with hemochromatosis (p = 0.036).ConclusionColombian patients with iron overload disorders show clinical, epidemiological, and biochemical profiles consistent with global patterns, yet exhibit distinct genetic diversity. Notably, they have a low prevalence of the C282Y mutation and a higher prevalence of the H63D mutation, differing from European HH profiles. Despite elevated ferritin and transferrin saturation, no significant clinical symptoms were observed, suggesting potential delays in diagnosis. These findings highlight the need for early, region-specific diagnostic approaches to prevent complications like cirrhosis and underscore the importance of further genetic research across Latin America.
Association of neutrophil-to-lymphocyte ratio and risk of all-cause and cardiovascular mortality in adults with metabolic dysfunction-associated steatotic liver disease: a population-based cohort study
Authors: Zhang Ying , Zhang Ai-Hua , Li Rong-Li , Li Wen-Jun , Liu Yun , Li Teng 
Published: December 2024

Background and objectiveInflammation is key to metabolic dysfunction-associated steatotic liver disease (MASLD) development. Nevertheless, the correlation between the inflammatory marker, neutrophil-to-lymphocyte ratio (NLR), and the MASLD prognosis remains unclear. We aim to determine the link between NLR and mortality risk in MASLD.MethodsThe MASLD adult participants from the 1999–2018 National Health and Nutrition Examination Survey (NHANES) database were evaluated. Utilizing restricted cubic spline (RCS) analyses, as well as Cox proportional hazards (PH) models, the associations between NLR and all-cause mortality (ACM) and cardiovascular mortality (CVM) were analyzed in MASLD. Subgroup analyses and interaction tests were conducted to validate these associations. Moreover, we used sensitivity analyses to ascertain the robustness of the results.ResultsThrough 115 months of median follow-up, 2,307 of the 16,859 participants with MASLD died, including 650 deaths from cardiovascular causes. RCS analyses showed positive linear associations between NLR and both ACM and CVM. In the multivariable-adjusted Cox PH model, a one-unit elevation in NLR was related to a hazard ratio (HR) of 1.16 (95% confidence interval [CI]: 1.12–1.21) for ACM and 1.21 (95% CI: 1.15–1.27) for CVM. Participants were classified into higher (≥ 2.88) and lower (&lt; 2.88) NLR groups employing the maximally selected rank statistics. The higher NLR group had a significantly elevated ACM (HR 1.38, 95% CI: 1.23–1.55) and CVM (HR 1.64, 95% CI: 1.32–2.03) risk compared to the lower NLR group. The associations were consistent in subgroup analyses based on age, gender, BMI, hypertension, and diabetes, with no significant interaction between NLR and these characteristics. Sensitivity analyses affirmed the main outcome’s robustness.ConclusionA raised NLR independently predicts escalated ACM and CVM in MASLD.
Case report: Therapeutic response to lorlatinib in advanced large-cell neuroendocrine carcinoma of the lung and breast cancer: a heterochronous double malignancy perspective
Authors: Mu Xiaoli , Li Yan 
Published: December 2024

BackgroundDriver mutations in tyrosine kinases, such as the anaplastic lymphoma kinase (ALK) mutation, are known to play a critical role in the pathogenesis of non-small cell lung cancer (NSCLC) but are rarely observed in large cell neuroendocrine carcinoma (LCNEC). Multiple primary malignancies (MPMs) refer to the occurrence of two or more distinct primary malignancies within the same or different organs and tissues in a single patient, either simultaneously or sequentially.Case PresentationWe reported a case of advanced LCNEC as a heterochronous double primary malignancy, following a prior breast cancer diagnosis in a 55-year-old woman. Ten years after achieving remission from breast cancer, the patient was diagnosed with LCNEC, presenting with multiple brain metastases (BMs) after undergoing surgery and adjuvant radiochemotherapy. She tested positive for the ALK fusion gene and received lorlatinib as an initial treatment. After 6 weeks, there was a significant reduction in the tumor, and the treatment impact was evaluated as a partial response. The treatment has been continued for over 25 months since the initiation of ALK Tyrosine kinase inhibitor (ALK-TKI) therapy.ConclusionThis case suggested that ALK-positive advanced LCNEC patients might benefit from first-line intervention with lorlatinib, particularly for managing brain metastases.
Comparison on self-determination, peer-relationship, and alienation in physical education of early adolescent in Korea and China
Authors: Jaeuk Jeong , Yu Sun , Donghwi Suh 
Published: December 2024

IntroductionIn order to identify effective strategies for enhancing a high-quality physical education system, it is imperative to undertake research that examines the nuances of educational culture, specifically focusing on the psychological experiences of early adolescents within physical education classes. This study aims to compare self-determination, peer-relationships, and feelings of alienation in physical education among adolescents from Korea and China, both situated in East Asia, with respect to their nationality and gender.MethodsOne hundred and twenty two early adolescent males (M = 14.34, SD = 0.65) and 78 females (M = 14.34, SD = 0.64) from South Korea and 125 early adolescent males (M = 14.13, SD = 0.58) and 70 females (M = 14.13, SD = 0.59) from China participated in this study, with a mean age of 14.24 ± 0.62. The Academic Self-Regulatory Scale (SRQ-A), Peer-relationship Questionnaire, and a Scale for Measuring Student Alienation in Physical Education were utilized for data analysis. For statistic comparisons, a t-test was used.ResultsSelf-determination of male and female students in China was significantly higher than that of male and female students in Korea, respectively. Peer-relationship of male students in Korea was significantly higher than that of male students in China. Physical education alienation of the female students in Korea was significantly higher than that of male students in Korea.DiscussionGiven that the influence of self-determination, peer relationships, and physical education alienation varies by nationality and gender, it is crucial to seek and implement strategies to develop an effective physical education system. By doing so, physical education alienation can be minimized and prevented, ultimately preserving the health and well-being of adolescents. This approach is vital for fostering a supportive and inclusive environment that promotes lifelong fitness and health.
The impact of team cohesion on athlete engagement in collegiate basketball leagues: the moderating role of paternalistic leadership
Authors: Wang Liang , Xu Jianhua , Liu Yao 
Published: December 2024

ObjectiveThis study investigates the impact of team cohesion on the engagement of college basketball players, and examines the moderating effects of authoritarian, benevolent, and moral leadership styles within paternalistic leadership on this influence. This provides theoretical insights for improving athlete engagement.MethodsData from 404 athletes participating in the 26th China Collegiate Basketball League were collected through a questionnaire survey and analyzed statistically.Results(1) Team cohesion has a significant positive impact on athlete engagement in collegiate basketball players. (2) Authoritarian leadership has a significant negative moderating effect on the relationship between team cohesion and athlete engagement in collegiate basketball players; the stronger the authoritarian leadership, the weaker the positive impact of team cohesion on athlete engagement in collegiate basketball players. This effect diminishes and becomes statistically insignificant when the authoritarian leadership score exceeds 5.88. (3) Benevolent leadership does not have a significant moderating effect between team cohesion and athlete engagement in collegiate basketball players. (4) Moral leadership has a significant positive moderating effect on the relationship between team cohesion and athlete engagement in collegiate basketball players; the higher the moral leadership, the stronger the positive impact of team cohesion on athlete engagement in collegiate basketball players, which becomes insignificant when the moral leadership score is below 2.75.ConclusionEnhancing team cohesion is an effective method to increase athlete engagement in collegiate basketball players. It is advisable for collegiate basketball coaches to refrain from adopting controlling and demeaning authoritative approaches, and instead, emphasize ethical leadership practices, continually enhancing their own abilities and virtues to serve as role models.
Food waste from Parkia biglobosa seed processing as a potential biomass resource for valorization
Authors: Oludipe Emmanuel Olorunleke , Ajayi Ayodele Oluwaseun , Owolabi Akinyomade Oladipo , Olojede Ayoyinka Olufunke , Afolabi Yemisi Tokunbo , Nwonuma Charles Obiora , Adewumi Blessing Grace , Dada Ebenezer Olasunkanmi , Owa Stephen Oluwagbemiga 
Published: December 2024

IntroductionThe valorization of agricultural waste from indigenous sub-Saharan African food processes remains underexplored. By-products from the processing of Parkia biglobosa seeds into condiments are often regarded as pollutants. This research assessed their potential for development in various industrial applications.Materials and methodsThis study employed a standardized protocol adopted in the processing of P. biglobosa seed into condiments, enabling the quantification of food and by-products generated as a percentage. A comparative analysis of the proximate and mineral constituents of the dried food condiment and seed coat (testa) was conducted. Furthermore, the phytochemical constituent of effluents from the two stages of processing was characterized using qualitative and quantitative methods, including Fourier-transform infrared spectroscopy (FTIR) and gas chromatography–mass spectrometry (GC–MS).Results and discussionThe results showed that 66.27% of each 100 g processed P. biglobosa seed used could be considered waste, with 23.19% in seed coat and 29.47% in effluent(s). The seed coat has moisture absorption potential and is fibrous in nature, as confirmed by proximate fiber analysis—15.03 ± 0.13% compared to 9.07 ± 0.10% in the dried condiment. Both the condiments and seed coat contained considerable amounts of sustenance minerals. Effluents from the boiling process exhibited a characteristic starchy effect on textiles. The concentrated effluent from the first stage of boiling had a chocolate-like aroma, sticky texture, and dark-brown color compared to the effluent from the second boiling stage. The FTIR analysis indicated the presence of alcohols, alkenes, aromatic rings, carboxylic acids, and amines in the effluent samples. GCMS characterization reported the presence of specific fatty acids with known health benefits. When premised on the waste-to-wealth initiative, the quantified and characterized by-products of P. biglobosa seed processing, as reported in this study, have potential applications across various industrial processes, including food, cosmetics, pharmaceutical, and agriculture, among others.
Ultra-low quiescent current off-chip capacitor-less low-dropout linear regulator with enhanced load-transient response for low-power IoT devices
Authors: Li Jingbo , Mizuno Yosuke , Sebe Hikaru , Sumi Shintaro , Kanemoto Daisuke , Hirose Tetsuya 
Published: December 2024

Abstract
This paper presents an off-chip capacitor-less low-dropout linear regulator (LDO) that incorporates a bias current generator (BCG) along with a current control circuit, a voltage monitor, and a voltage comparison circuit. The enhancements significantly improve load transient response and prevent overcurrent during startup, addressing key limitations of conventional BCG-based designs. Measurement results demonstrate stable operation with a 1.2 V output and a quiescent current of 128 nA, achieving line regulation of 1.36 mV V−1 and load regulation of 3.55 mV mA−1. The LDO is capable of sustaining operation with up to a 20 mA load current without the need for off-chip capacitors, reducing system cost and size while ensuring reliable performance for ultra-low-power applications.
Synthesis, Identification some of new heterocyclic Compounds Derivatives and study of the biological Activity
Authors: Rusul Ali Muhammad  , Rajaa A. A. Ghafil  
Published: December 2024

This research includes prepeared of some new heterocyclic compounds from 2-hydroxy napthaldehyde with 2-amino thiazol , 2-amino thiazol reacted with 2-hydroxy napthaldehyde , to produce shiff base derivative (R),(R) using to synthesis of some new heterocyclic derivatives by reactions and reactant with types solvent and materials to synthesis heterocyclic membered ring , first step : Involved synthesis of seven heterocyclic compounds by reacting (R) with phthalic ,succinic and malic anhydride respectfully to prepeared oxazepine compounds (R1,R2,R3) . Second step involves preparing of five- heterocyclic derivatives by reacting (R) with amino acid glycine and thyrocine in tetra hydro furan to prepare (R4,R5).Third step includes preparing of four heterocyclic compounds β-lactam(S6). All the compounds were characterized by FT-IR ,H1NMR,13CNMR .Also compounds were studied the measurement antibacterial activity.
Pamiętniki rękopiśmienne ze zbiorów Biblioteki Narodowej jako źródło do badań nad dzieciństwem w Królestwie Polskim przełomu XIX i XX wieku
Authors: Nawrot-Borowska Monika , Wałęga Agnieszka 
Published: December 2024

Przedmiotem niniejszego tekstu są wspomnienia z okresu dzieciństwa przełomu XIX i XX wieku związane z obszarem Królestwa Polskiego. Celem badań jest wskazanie, jakie aspekty dzieciństwa pojawiają się w narracjach autorów, wywodzących się z różnych grup społecznych. Ustalenia te posłużyć mogą badaczom do podjęcia pogłębionych badań nad specyfiką dzieciństwa wskazanego okresu z uwzględnieniem najnowszych orientacji teoretycznych i metodologicznych. Analizie poddano niepublikowane dotąd pamiętniki, przechowywane w zbiorach rękopisów Biblioteki Narodowej. Kryterium wyboru materiału źródłowego stanowiła data urodzin autora (od schyłku lat 80. XIX wieku do początków wieku XX, tak, aby okres dzieciństwa przypadał na ostatnie lata zaborów) oraz terytorium Królestwa Polskiego, jako miejsca, w którym dany pamiętnikarz spędził lata dzieciństwa. Po szczegółowej analizie kilkudziesięciu pamiętników spełniających powyższe kryteria wybrano 30 rękopisów, które stanowić mogą wartościowe poznawczo źródło do badań nad dzieciństwem i wychowaniem dziecka w rodzinie w ostatnim 40. leciu funkcjonowania Królestwa Polskiego.
Edukacja rodzicielska dziecka w koncepcji Jana Amosa Komeńskiego
Authors: Waszek Agata 
Published: December 2024

Jan Amos Komeński wybitny czeski pedagog (również filozof, teolog) w swojej twórczości szczególną uwagę poświęcił chrześcijańsko-humanistycznemu prowadzeniu życia. Jako jeden z pierwszych pedagogów dostosował w zakresie metodycznym oraz doboru treści nauczanie do etapów rozwoju psychofizycznego ucznia. Podróżujący i poszukujący skutecznych rozwiązań w nauczaniu i uczeniu się. W Polsce, którą uważał za drugą ojczyznę i w której przebywał po przymusowej emigracji z Czech, stworzył najwięcej dzieł literackich. Opracował wiele podręczników, w tym poświęconych zagadnieniom pedagogicznym, jak również dydaktycznych. Uznawany jest za jednego z prekursorów pedagogiki przedszkolnej, andragogiki, oraz pedagogiki specjalnej.
Katalogisasi Naskah Kuno Sebagai Pelestarian Informasi Naskah
Authors: Nur Aisyah Sofia , Lawanda Ike Iswary 
Published: December 2024

There is a need to preserve manuscript information in an effort to save it, one of which is cataloging, which will make it easier for users to access manuscript searches. This article will discuss the techniques used in the process of cataloging ancient manuscripts, the contributions made to the cataloging of ancient manuscripts, and the challenges faced in the process of cataloging ancient manuscripts for the preservation of their information. The method used in this research is a systematic literature review (SLR) using publication citation limits from the period 2018–2023, or the last 6 years. The results show that various cataloging techniques rely on descriptive information from manuscripts to identify ancient manuscripts with diverse languages and characters. Apart from that, the use of bibliographic records and comparing standards to adjust the condition of manuscripts is also used in manuscript cataloging techniques. The contribution of cataloging ancient manuscripts has influenced aspects such as inaccuracies, digitization, software development, and standardization. Challenges in cataloging ancient manuscripts include technical issues such as inaccuracies and mistrust, as well as operational challenges due to limited resources and funding.
KAJIAN YURIDIS PENERAPAN PRINSIP UTMOST GOOD FAITH DALAM SENGKETA KLAIM ASURANSI JIWA SYARIAH
Authors: Muhammad Najib  , R. Murjiyanto  , Eksy Puji Rahayu  
Published: December 2024

Disputes regarding insurance often occur because of the absence of honesty from one of the parties even though in the principle of insurance known as the principle of utmost good faith or good faith. Utmost good faith is honesty by the Insurer regarding the terms and conditions of insurance and the Insured himself must also provide clear and honest information about the object insured, this study aims to provide an understanding of the application of the principle of utmost good faith in life insurance as a form of legal protection for the Insurer and the Insured and to find out the Judge's consideration of the life insurance claim case in decision No. 303/Pdt.G/2020/PA. Smn jo No. 73/Pdt.G/2020/PTA. Yk jo. No. 521 K/Ag/2021. This type of research uses normative legal research methods of descriptive nature by conducting a qualitative juridical approach and a case approach, data sources are obtained based on secondary and primary data sources, data collection is obtained by interviews, reviewing legal materials and literature studies. The analysis is carried out qualitatively and then the data obtained are selected and compiled systematically then interpreted to see their suitability with applicable provisions and then concluded to get answers to the problems raised. Based on the analysis that has been done, it is found that hiding information and / or information that is not true, this action is a violation of the principle of utmost good faith which can result in the cancellation of the insurance agreement that has been made with the Insurer, so that in Decision No. 303 / Pdt.G / 2020 / PA. Smn Jo. No. 73/Pdt.G/2020/PTA. Yk Jo. No. 521 K/Ag/2021 that the Insurer's act of not being willing to pay insurance claims to the Plaintiff has legal reasons and does not constitute default.
Spinal Accessory Nerve to Suprascapular Nerve Neurotization for Brachial Plexus Injury: A Retrospective Study
Authors: Seti Aji Hadinoto  , Raditya Ramadhan  
Published: December 2024

Introduction: Brachial plexus injuries (BPIs) often lead to significant functional impairment of the upper extremity, particularly affecting shoulder abduction and external rotation. Spinal accessory nerve (SAN) to suprascapular nerve (SSN) neurotization is a surgical technique employed to restore shoulder function in these patients. This study aimed to evaluate the outcomes of this procedure in a series of patients with BPI.
Methods: A retrospective observational case series study was conducted, including patients who underwent SAN to SSN neurotization for BPI at a single institution between January 2019 and December 2021. Patient demographics, injury characteristics, surgical details, and functional outcomes were collected from medical records. Functional outcomes were assessed using the Disabilities of the Arm, Shoulder, and Hand (DASH) score preoperatively and at the final follow-up.
Results: A total of 8 patients were included in the study. The mean age was 25.7 years (range, 12-39 years), with a majority being male (55.6%). The most common cause of BPI was motor vehicle accidents (90%). The mean DASH score improved significantly from 72.5 preoperatively to 37.5 postoperatively (p<0.05).
Conclusion: SAN to SSN neurotization appears to be a safe and effective technique for improving shoulder function in patients with BPI. This study demonstrated significant improvements in DASH scores following the procedure. However, further research with larger sample sizes and longer follow-up periods is needed to confirm these findings and evaluate the long-term outcomes of this technique.