bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decision risk approach to the application of biological indicators in vapor phased hydrogen peroxide bio‐decontamination
Authors: Pusztai Éva , Kemény Sándor , Vágó Emese , Horváth Anikó 
Published: February 2018

AbstractThe ensuring of sterile conditions during pharmaceutical production is of vital importance. Restricted access barrier systems may not be sterilized in the usual way. Instead, vaporous hydrogen peroxide decontamination is used. The success of the decontamination is checked by placing biological indicators (BIs), and upon their removal, putting them individually into broth for incubation. This technique does not allow counting the number of microorganisms but to detect the survival of any of them and thus counting the negative/positive answers. The Poisson distribution gives the connection between the number of viable spores and the number of positive (growth) BIs. Evaluation is based on the number of surviving BIs, which is probabilistic by nature. Acceptance limits are based on good engineering assumptions (“current industrial experience”), not on sound decision theory statistics (probability of error of the first and second kind). The reason of existence of surviving BI is either the process lethality failure or the limited penetrative capability of vaporous hydrogen peroxide. The latter phenomenon is called “rogue” BIs, and it should be distinguished. The method of the evaluation of the success of the decontamination is consistent with attribute sampling plans. In this paper, relations are explored to calculate the 2 types of error that can be applied in general during the qualification of a bio‐decontamination procedure. This is, to the best knowledge of the authors, the first ever application of attribute sampling plans to evaluate the results of a BI used bio‐decontamination process.
Finely Controlled Stepwise Engineering of Pore Environments and Mechanistic Elucidation of Water‐Stable, Flexible 2D Porous Coordination Polymers
Authors: Wang Haijun , Cao Haifei , Zheng Jia‐jia , Mathew Simon , Hosono Nobuhiko , Zhou Bihang , Lyu Hongliang , Kusaka Shinpei , Jin Wanqin , Kitagawa Susumu , Duan Jingui 
Published: February 2018

AbstractTwo porous coordination polymers (PCPs) with different topologies (NTU‐19: sql and NTU‐20: dia) underwent finely controlled, stepwise crystal conversions to yield a common water‐stable, flexible 2D framework (NTU‐22: kgm). The crystal conversions occurred directly at higher temperature via the 3D intermediate (NTU‐21: nbo), which could be observed at lower temperature. The successful isolation of the intermediate product of NTU‐21, characterization with in situ PXRD and UV/Vis spectra were combined with DFT calculations to allow an understanding of the dynamic processes at the atomic level. Remarkably, breakthrough experiments demonstrate NTU‐22 with integral structural properties allowed significant CO2/CH4 mixture separation.
Spectroscopic Studies on Photoinduced Reactions of the Anticancer Prodrug, trans,trans,trans‐[Pt(N3)2(OH)2(py)2]
Authors: Vernooij Robbin R. , Joshi Tanmaya , Horbury Michael D. , Graham Bim , Izgorodina Ekaterina I. , Stavros Vasilios G. , Sadler Peter J. , Spiccia Leone , Wood Bayden R. 
Published: February 2018

AbstractInvited for the cover of this issue are the groups of Peter J. Sadler at the University of Warwick and Bayden R. Wood at Monash University. The image depicts a platinum(IV) anticancer prodrug, the light‐activated release of its hydroxide and azide ligands, and reduction to platinum(II) as detected by our global collaboration using infrared spectroscopy combined with a range of other methods. Read the full text of the article at https://doi.org/10.1002/chem.201705349.
Modifying oligoalanine conformation by replacement of amide to ester linkage
Authors: Hongen Takahiro , Taniguchi Tohru , Monde Kenji 
Published: February 2018

AbstractOligo(lactic acid) is an ester‐analogue of short oligoalanine sequence and adopts a rigid left‐handed helical structure. In this study, oligo(lactic acid) was incorporated into oligoalanine sequences and their conformations were studied by vibrational circular dichroism and electronic circular dichroism spectroscopy. The results suggested that oligo(lactic acid) moiety in these sequences maintains a left‐handed helix and increases the conformational propensity of the oligoalanine moiety to form a left‐handed polyproline type II‐like helix. The importance of the chirality of oligo(lactic acid) moiety for the oligoalanine conformation was also studied. The results obtained in this study should be useful in developing ester‐containing oligopeptides that function better than normal peptides.
Seascape models reveal places to focus coastal fisheries management
Authors: Stamoulis Kostantinos A. , Delevaux Jade M. S. , Williams Ivor D. , Poti Matthew , Lecky Joey , Costa Bryan , Kendall Matthew S. , Pittman Simon J. , Donovan Mary K. , Wedding Lisa M. , Friedlander Alan M. 
Published: February 2018

AbstractTo design effective marine reserves and support fisheries, more information on fishing patterns and impacts for targeted species is needed, as well as better understanding of their key habitats. However, fishing impacts vary geographically and are difficult to disentangle from other factors that influence targeted fish distributions. We developed a set of fishing effort and habitat layers at high resolution and employed machine learning techniques to create regional‐scale seascape models and predictive maps of biomass and body length of targeted reef fishes for the main Hawaiian Islands. Spatial patterns of fishing effort were shown to be highly variable and seascape models indicated a low threshold beyond which targeted fish assemblages were severely impacted. Topographic complexity, exposure, depth, and wave power were identified as key habitat variables that influenced targeted fish distributions and defined productive habitats for reef fisheries. High targeted reef fish biomass and body length were found in areas not easily accessed by humans, while model predictions when fishing effort was set to zero showed these high values to be more widely dispersed among suitable habitats. By comparing current targeted fish distributions with those predicted when fishing effort was removed, areas with high recovery potential on each island were revealed, with average biomass recovery of 517% and mean body length increases of 59% on Oahu, the most heavily fished island. Spatial protection of these areas would aid recovery of nearshore coral reef fisheries.
Feasibility of a parent education and skills workshop for improving response to family‐based treatment of adolescent anorexia nervosa
Authors: Ganci Maria , Pradel Martin , Hughes Elizabeth K. 
Published: February 2018

AbstractObjectiveEarly response to family‐based treatment (FBT) is a robust predictor of positive outcomes for adolescents with anorexia nervosa (AN). We introduced a parent education and skills workshop in the first 4 weeks of treatment with the aim of improving changes in parent self‐efficacy in FBT and, in turn, patient weight gain.MethodForty‐five families who had at least one parent attend the workshop were compared to a matched control of families who did FBT before the workshop was introduced.ResultsAmong adolescents who were underweight at baseline, weight gain by Week 4 of treatment was higher for adolescents whose parents attended the workshop (M = 90.84% median BMI) than those who did not (M = 88.54% mBMI, p < .05). There was no significant difference in weight at Week 12 or at end of treatment, nor was there a difference in self‐efficacy as measured by the Parent Versus Anorexia Scale. Participants reported a high level of satisfaction with the workshop and significant improvements in knowledge and confidence.DiscussionOverall, the workshop was a feasible adjunct for improving early response to FBT.
Electrochemical Detection of Acetaminophen with Silicon Nanowires
Authors: Pandey Raja Ram , Alshahrani Hussain S. , Krylyuk Sergiy , Williams Elissa H. , Davydov Albert V. , Chusuei Charles C. 
Published: February 2018

AbstractAcetaminophen (APAP) is an antipyretic, analgesic agent, the overdose of which during medical treatment poses a risk for liver failure. Hence, it is important to develop methods to monitor physiological APAP levels to avoid poisoning. Here, we report an efficient, selective electrochemical APAP sensor made from depositing silicon nanowires (SiNWs) onto glassy carbon electrodes (GCEs). Electrocatalytic activity of the SiNW/GCE sensors was monitored under varying pH and concentrations of APAP using cyclic voltammetry (CV) and chronoamperometry (CA). CV of the SiNWs at 0.5 to 13 mmol dm−3 APAP concentrations was used to determine the oxidation and reduction potentials of APAP. The selective detection of APAP was then demonstrated using CA at +0.568 V vs Ag/AgCl, where APAP is fully oxidized, in the 0.01 to 3 mmol dm−3 concentration range with potentially‐interfering analytes. The SiNW sensor has the ability to detect APAP well within the detection limits for APAP toxicity, showing promise as a practical biosensor.
Updates on resources, software tools, and databases for plant proteomics in 2016–2017
Authors: Misra Biswapriya B. 
Published: February 2018

AbstractProteomics data processing, annotation, and analysis can often lead to major hurdles in large‐scale high‐throughput bottom‐up proteomics experiments. Given the recent rise in protein‐based big datasets being generated, efforts in in silico tool development occurrences have had an unprecedented increase; so much so, that it has become increasingly difficult to keep track of all the advances in a particular academic year. However, these tools benefit the plant proteomics community in circumventing critical issues in data analysis and visualization, as these continually developing open‐source and community‐developed tools hold potential in future research efforts. This review will aim to introduce and summarize more than 50 software tools, databases, and resources developed and published during 2016–2017 under the following categories: tools for data pre‐processing and analysis, statistical analysis tools, peptide identification tools, databases and spectral libraries, and data visualization and interpretation tools. Intended for a well‐informed proteomics community, finally, efforts in data archiving and validation datasets for the community will be discussed as well. Additionally, the author delineates the current and most commonly used proteomics tools in order to introduce novice readers to this ‐omics discovery platform.
Accelerated SDS depletion from proteins by transmembrane electrophoresis: Impacts of Joule heating
Authors: Unterlander Nicole , Doucette Alan Austin 
Published: February 2018

AbstractSDS plays a key role in proteomics workflows, including protein extraction, solubilization and mass‐based separations (e.g. SDS‐PAGE, GELFrEE). However, SDS interferes with mass spectrometry and so it must be removed prior to analysis. We recently introduced an electrophoretic platform, termed transmembrane electrophoresis (TME), enabling extensive depletion of SDS from proteins in solution with exceptional protein yields. However, our prior TME runs required 1 h to complete, being limited by Joule heating which causes protein aggregation at higher operating currents. Here, we demonstrate effective strategies to maintain lower TME sample temperatures, permitting accelerated SDS depletion. Among these strategies, the use of a magnetic stir bar to continuously agitate a model protein system (BSA) allows SDS to be depleted below 100 ppm (>98% removal) within 10 min of TME operations, while maintaining exceptional protein recovery (>95%). Moreover, these modifications allow TME to operate without any user intervention, improving throughput and robustness of the approach. Through fits of our time‐course SDS depletion curves to an exponential model, we calculate SDS depletion half‐lives as low as 1.2 min. This promising electrophoretic platform should provide proteomics researchers with an effective purification strategy to enable MS characterization of SDS‐containing proteins.
Quality of life during the first year after partial laryngectomy: Longitudinal study
Authors: Clasen Daniel , Keszte Judith , Dietz Andreas , Oeken Jens , Meister Eberhard F. , Guntinas‐Lichius Orlando , Pabst Friedemann , Büntzel Jens , Jenzewski Eva‐Maria , Singer Susanne , Meyer Alexandra 
Published: February 2018

AbstractBackgroundThis prospective study was conducted to assess changes in quality of life (QOL) of patients who undergo a partial laryngectomy.MethodsThe European Organisation for Research and Treatment of Cancer Quality of Life Questionnaires Core and Head and Neck (EORTC‐QLQ‐C30, QLQ‐H&N35) were used preprocedure (n = 218), 1 week (n = 159), 3 months (n = 122), and 1 year after partial laryngectomy (n = 88). Changes over time were analyzed with the Wilcoxon signed rank test and the Holm‐Bonferroni method, and interpreted regarding clinical relevance.ResultsMost subscales worsened 1 week postprocedure, but many recovered to baseline level after 1 year. Dyspnea and cognitive functioning deteriorated over time, with worst scores recorded after 1 year. Financial difficulties and fatigue increased after surgery and maintained that level throughout the follow‐up period; sticky saliva remained worse than at baseline, despite some improvements over time.ConclusionThe discovered limitations of QOL should be observed more closely during follow‐up treatment, and patients should be informed about these potential effects before partial laryngectomy.
Thyroidectomy in patients who have undergone gastric bypass surgery
Authors: Goldenberg David , Ferris Robert L. , Shindo Maisie L. , Shaha Ashok , Stack Brendan , Tufano Ralph P. 
Published: February 2018

AbstractBackgroundMorbid obesity is a chronic condition that may be challenging to treat. Gastric bypass surgery is used to treat morbid obesity and its complications. Hypocalcemia, a known complication after thyroidectomy, is usually transient and treatable. There is a growing body of literature indicating that patients with previous gastric bypass surgery are at an increased risk for recalcitrant, symptomatic hypocalcemia after thyroidectomy. The management of hypocalcemia in patients with prior gastric bypass surgery may be exceedingly difficult.MethodsRelevant articles published between 2008 and January 2017 were reviewed by topic. The review of literature was conducted using a systematic search of database resources, such as PubMed and EMBASE.ResultsPrior gastric bypass surgery may be an independent risk factor for developing profound hypocalcemia after thyroid surgery.ConclusionRefractory hypocalcemia in patients who have undergone gastric bypass surgery is underreported. Careful consideration should be given to performing staged thyroidectomy and, in some cases, reversal of the bariatric surgery.
“There is always a better way”: Managing uncertainty in decision making about new cancer drugs in Canada
Authors: Driedger S. Michelle , Cooper Elizabeth , Annable Gary , Brouwers Melissa 
Published: February 2018

SummaryPolicy decisions about the approval and funding of new cancer drugs must often be made in an environment of complex uncertainty about clinical and cost‐effectiveness data. The focus of this article is on the results from qualitative interviews with senior officials (n = 16) who make decisions about or influence cancer drug policy in various organizations in the Canadian cancer control system. Most participants identified the use of a limited number of informal approaches to address uncertainty, such as grounding decisions in evidence and advice from expert groups. People tended to focus on evidence informed decisions including price negotiations, the ability to implement policy changes, and stakeholder values. Lessons from the Canadian context related to continuing efforts to build a public culture of understanding into how policy decisions like cancer drug funding are made may result in greater acceptance and increased confidence in health policy decision‐making processes across multiple sectors internationally.
Building hospital capacity planning mechanisms in Poland: The impact of 2016/2017 regulatory changes
Authors: Dubas‐Jakóbczyk Katarzyna , Sowada Christoph , Domagała Alicja , Więckowska Barbara 
Published: February 2018

SummaryCapacity planning is a crucial component of modern health care governance. The aim of this paper is to analyze the requirements that need to be met to build effective hospital capacity planning mechanisms in Poland. In this context, the recent regulatory changes strongly influencing hospital sector functioning, including introduction of health care needs maps, capital investment assessment, and hospital network regulations, are analyzed. Some possible ways forward, based on review of international experiences in hospital capacity planning, are discussed. Applied methods include literature review and analysis of statistical data as well as desk analysis of key national regulations related to hospital sector. Results indicate that at the system level, the process of capacity planning involves 4 elements: capital investment in facilities, equipment, and technology; service delivery; allocation of staff; and financial resources. For hospital capacity planning to be effective, the strategic decision at the macrolevel must be complemented by appropriate management of individual hospitals. The major challenge of building hospital capacity planning mechanism in Poland is imbedding it into the overall health system strategy. Because of the lack of such a strategy, the practical implementation of the ad hoc changes, which have been introduced, shows some inconsistencies. The regulations implemented between 2016 and 2017 provided a basis for hospital capacity planning, yet still need evaluation and adjustments. Also, including a mechanism for human resources planning is of crucial importance. The regulations should provide incentives for reducing oversized hospital infrastructure with simultaneous development of the long‐term and coordinated care models.
Factors that influence public awareness of domestic waste characteristics and management in rural areas
Authors: Han Zhiyong , Duan Qingqing , Fei Yongqiang , Zeng Dan , Shi Guozhong , Li Haimei , Hu Meilun 
Published: February 2018

Abstract

Public awareness of domestic waste characteristics and management (PADWCM) is a prerequisite for a domestic waste management (DWM) plan. In this study, we considered China as a typical example of developing countries to investigate the public perception of environmental pollution (PEP), its PADWCM, and its socioeconomic factors, using questionnaires and statistical methods. The results indicated that the public PEP was mainly due to obvious environmental contamination in local villages, and the PADWCM is still inadequate in rural areas. However, 83.9% of the respondents agreed that DWM is highly necessary. The PADWCM, including the hazard, recyclability, and characteristic pollution caused by domestic waste, was learned mainly from people's direct PEP, experiences, and repurchasing by recyclers. Education period had highly significant positive correlations and regressions with PEP and PADWCM, respectively. Additionally, education directly affected public awareness in different income and age groups. Demonstration projects had a significant positive effect on the awareness of characteristic pollution caused by domestic waste, which was readily perceived. Propaganda had a significant positive influence on the awareness of treatment necessity. Age and gender had no obvious effects on public PEP and PADWCM. Some aspects of PADWCM requiring a deep understanding became stronger as income increased; however, the PADWCM located close to poor people became weaker. Some aspects of PEP could significantly influence the awareness of characteristic pollution caused by domestic waste and awareness of treatment necessity. Therefore, improving environmental education, performing demonstration projects and effective environmental propaganda, increasing people's income, and attracting young people to participate in DWM will be important for enhancing environmental awareness and DWM in rural areas. Integr Environ Assess Manag 2018;14:395–406. © 2018 SETAC

Key Points
Public awareness of domestic waste characteristics and management (PADWCM) was learned from people's perception, experiences, and recyclers’ repurchase. Education had significant positive correlations and regressions with PADWCM. Demonstration significantly affected awareness of domestic waste pollution. Perception of pollution influenced awareness of domestic waste pollution and treatment necessity.
mRNA‐Independent way to regulate translation elongation rate in eukaryotic cells
Authors: Negrutskii Boris , Vlasenko Dmytro , Mirande Marc , Futernyk Pavlo , El'skaya Anna 
Published: February 2018

AbstractThe question of what governs the translation elongation rate in eukaryotes has not yet been completely answered. Earlier, different availability of different tRNAs was considered as a main factor involved, however, recent data revealed that the elongation rate does not always depend on tRNA availability. Here, we offer another, codon‐independent approach to explain specific tRNA‐dependence of the elongation rate in eukaryotes. We hypothesize that the exit rate of eukaryotic translation elongation factor 1A (eEF1A)*GDP from the 80S ribosome depends on the protein affinity to specific aminoacyl‐tRNA remaining on the ribosome after GTP hydrolysis. Subsequently, a slower dissociation of eEF1A*GDP from certain aminoacyl‐tRNAs in the ribosome can negatively influence the ribosomal elongation rate in a tRNA‐dependent and mRNA‐independent way. The specific tRNA‐dependent departure rate of eEF1A*GDP from the ribosome is suggested to be a novel factor contributing to the overall translation elongation control in eukaryotic cells. © 2018 IUBMB Life, 70(3):192–196, 2018
High defibrillation threshold with a subcutaneous implantable cardiac defibrillator due to the lead having been positioned in the fat layer
Authors: Hirao Tatsuhiko , Nitta Junichi , Sato Akira , Takahashi Yoshihide , Goya Masahiko , Hirao Kenzo 
Published: February 2018

AbstractA 46‐year‐old female with a body mass index of 38.9 kg/m2 and no organic heart disease underwent a subcutaneous implantable cardioverter‐defibrillator implantation for secondary prevention of sudden cardiac death in the setting of idiopathic ventricular fibrillation. Defibrillation threshold (DFT) testing during implantation detected high shock impedance and high DFT. Fluoroscopy revealed subcoil fat between the lead and the sternum, which we suspected was the reason for the high shock impedance and high DFT. We repositioned the lead to a site just above the sternum and the shock impedance and DFT improved to within the respective normal ranges.