bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PENAMBAHAN TEPUNG SUKUN (Artocarpus communis), PISANG HIJAU (Musa paradisiaca L.), COKLAT (Theobroma cacao L.) DAN KURMA (Phoenix dactylifera) TERHADAP DAYA TERIMA DAN NILAI KARBOHIDRAT EGG ROLL
Authors: Hafidha Kholifatul , Ismawati Rita 
Published: October 2018

Carbohydrates have an important role for endurance athletes to replenish glycogen in muscle and liver that had been used during muscle contraction. This research aims to analyze the effect of adding breadfruit flour (Artocarpus communis), green banana (Musa paradisiaca L.), dates (Phoenix dactylifera) and chocolate (Theobroma cacao L.) toward the acceptance and carbohydrate content of egg roll as an alternative snack for endurance athletes. This research use True Experimental Research, completely randomized design with four formula and repeated four times for each formula. Panelist in this study consist of 30 athletes of Local Training Center, Indonesian National Sport Committee in East Java Region. Based on the test of acceptance on the modification of egg roll formula, the most preferred formula was F1 (breadfruit flour 150 g, chocolate 500 g, dates 150 g) with the highest mean rank values were on color (2.65) and flavor (2.70), while the aroma and texture aspect had the lower mean rank (2.50) each compared to F0 (2.87 and 2.58). The result of Friedman Test statistic on all characteristics of the acceptability include color, aroma, texture and flavor found there was not significant diffrence on the acceptance of egg roll (p>0.05). The highest carbohydrate content was F1 (59.4/100 g). Based on the best acceptance value and the highest carbohydrate content, it was conclude that the optimal formula was F1. Total egg roll that should be consumed by the athletes before sport was 125 grams (12 sticks egg roll) and 60-95 grams (6-8 sticks egg roll) for after sport
HUBUNGAN TINGKAT KEMATANGAN DAN SUHU DENGAN SISA MAKANAN LAUK NABATI PADA PASIEN ANAK DI RUANG INAP RUMKITAL DR. RAMELAN SURABAYA
Authors: Saskia Renata , Primadona Suzanna , Mahmudiono Trias 
Published: October 2018

Food evaluation in a hospital can be seen from patient’s plate waste. Plate waste can be infl uenced by patient's perception of the food served, such as appearance and taste. The aim of this study was to analyze the relationshipof cooked level and temperature of vegetable side dishes with plate waste in the pediatric patient at naval hospital Dr. Ramelan Surabaya. The study was using cross sectional design. The sample of the study was thirty-two pediatricpatient. The data collected through interview using a questionnaire and plate waste was observed by Comstock method. Chi-square was used to analyzed the correlation of cooked level and temperature of vegetable side dishes with platewaste. The results showed that there was a relationship between cooked level, the temperature of the vegetable side dish and plate waste which served on dinner time (p=0.049 and p=0.040), but there was no relationship between cooked level, the temperature of vegetable side dish and plate waste on lunch time (p=0.994 and p=0.505). There was a weak relationship between taste, aroma, portion with the patient's plate waste, due to the different appetite, eating habits and physiological conditions of the patients.
Mitigating peak pressure of storm geysering by orifice plates installed at the top of vent pipes
Authors: Huang Biao , Wu Shiqiang , Zhu David Z. , Wang Fangfang 
Published: October 2018

Abstract
Large air pockets can be trapped in storm sewer systems during intense rain events. Uncontrolled release of these air pockets may cause geysering and pressure surges, resulting in flooding, pipe failures and safety issues. Thus, there is a great need to develop methods to retrofit existing sewer systems and to provide guidance on system design. A large-scale physical model was established to evaluate air-control orifice plates in reducing geysering intensity by utilizing air cushion effects over the process of air escape. Experimental results indicate that the magnitude of pressure fluctuations can be reduced significantly with partially open vent pipes. The maximum pressure head can be reduced by approximately two-thirds, and the magnitude of relative pressure oscillation decreased by about 95% when the diameter ratio of the air-control orifice to the vent pipe is below 25%. Air–water mixture jets can be avoided in such cases. The effect of using multiple vent pipes with orifice plates was also evaluated and found to be effective. Thus, air-control vent pipes can be applied to alleviate geysering and related pressure transients.
The Role of PCSK9 in the Pathogenesis of Non-alcoholic Fatty Liver Disease and the Effect of PCSK9 Inhibitors
Authors: Theocharidou Eleni , Papademetriou Marianna , Reklou Andromachi , Sachinidis Alexandros , Boutari Chrisoula , Giouleme Olga 
Published: October 2018

Background:
Statin treatment exhibits a beneficial effect on non-alcoholic fatty liver disease (NAFLD)
and on cardiovascular disease (CVD) in patients with NAFLD.

Objective:
The aim of this review is to summarize the role of proprotein convertase subtilisin kexin type-
9(PCSK9) in the pathogenesis of NAFLD and discuss the effects of the new hypolipidaemic drugs PCSK9 inhibitors
on NAFLD.

Results:
Data indicates that high intrahepatic or circulating PCSK9 levels increase muscle and liver lipid storage,
adipose energy storage and hepatic fatty acids, as well as triglycerides storage and secretion, thus contributing to
the pathogenesis of NAFLD. The findings of animal and human studies, aiming to reduce PCSK9 with inhibitors
(human IGG antibodies, antisense particles against PCSK9 mRNA, and small anti PCSK9 antibodies) point towards
liver protection from NAFLD through inhibition of PCSK9 expression in the induction of degradation of
hepatic HNF1a protein, insulin resistance (IR), and other mechanisms.

Conclusions:
The use of PCSK9 inhibitors ameliorates NAFLD, aside from beneficial effects on CVD and independently
of low density lipoprotein cholesterol level reduction.
Should we Consider Lipoprotein (a) in Cardiovascular Disease Risk Assessment in Patients with Familial Hypercholesterolaemia?
Authors: Anagnostis Panagiotis , Siolos Pavlos , Krikidis Dimitrios , Goulis Dimitrios G. , Stevenson John C. 
Published: October 2018

Background:
Familial hypercholesterolaemia (FH) is a genetically determined lipid disorder, affecting
1 per 200-500 individuals in the general population. It is significantly and independently associated with an
increased risk of Cardiovascular Disease (CVD), although it remains still an underrecognized and undertreated
disease. Lipoprotein (a) [Lp(a)] is a low-density-lipoprotein (LDL)-like molecule, containing an additional protein,
apolipoprotein (a).

Objective:
This review aims to present and discuss available data on the role of Lp(a) in patients with FH, in
terms of its potential augmentation of CVD risk.

Methods:
A comprehensive search of the literature was performed to identify studies evaluating the CV effects of
Lp(a) in patients with FH.

Results:
Lp(a) has been recognised as an independent risk factor for CVD, mainly coronary artery disease (CAD).
Most, but not all, studies show increased Lp(a) concentrations in adults and children with FH. There is also evidence
of an independent association between Lp(a) and CVD (mainly CAD) risk in these patients.

Conclusion:
Some therapeutic modalities, such as niacin, oestrogens, tibolone and proprotein convertase subtilisin/
kexin type 9 (PCSK9) inhibitors may effectively reduce Lp(a) concentrations by 25-30%, although their
clinical benefit of this effect remains to be established.
Phytochemistry, Traditional Uses and Pharmacological Profile of Rose Hip: A Review
Authors: Ayati Zahra , Amiri Mohammad S. , Ramezani Mahin , Delshad Elahe , Sahebkar Amirhossein , Emami Seyed A. 
Published: October 2018

Background:
The fruit of genus Rosa, known as "rose hip", is frequently used in different traditional
medicines. Rose hips have long been used to treat kidney stones, gastroenteric ailments, hypertension and respiratory
problems such as bronchitis, cough and cold.

Aim:

This review is focused on the ethnopharmacological uses of rose hip as well as phytochemical and pharmacological
aspects.

Results:
Ethno-medical uses of rose hip have been recorded in many countries since a long time. Approximately,
129 chemical compounds have been isolated and identified from rose hip. This fruit contains some major active
components such as flavonoids, tannins, anthocyanin, phenolic compounds, fatty oil, organic acids and inorganic
compounds. Scientific studies have suggested a wide range of pharmacological activities for rose hip including
antioxidant, anti-inflammatory, anti-obesity, anti-cancer, hepatoprotective, nephroprotective, cardioprotective,
antiaging, anti H. pylori, neuroprotective and antinociceptive activities. In particular, the rose hip powder and
extract have been reported to exert therapeutic effects on arthritis.

Conclusion:
Some of the ethnomedical indications of rose hip, such as nephroprotective and gastroproetctive
actions, have been confirmed by preclinical pharmacological studies. Additional investigations on the pharmacological
effects of rose hip as well as evidence from randomized controlled trials are essential to assess the
therapeutic value of this natural product.
Alkylphospholipids are Signal Transduction Modulators with Potential for Anticancer Therapy
Authors: Kaleağasıoğlu Ferda , Zaharieva Maya M. , Konstantinov Spiro M. , Berger Martin R. 
Published: October 2018

Background:Alkylphospholipids (APLs) are synthetically derived from cell membrane components, which they target and thus modify cellular signalling and cause diverse effects. This study reviews the mechanism of action of anticancer, antiprotozoal, antibacterial and antiviral activities of ALPs, as well as their clinical use.Methods:A literature search was used as the basis of this review.Results:ALPs target lipid rafts and alter phospholipase D and C signalling cascades, which in turn will modulate the PI3K/Akt/mTOR and RAS/RAF/MEK/ERK pathways. By feedback coupling, the SAPK/JNK signalling chain is also affected. These changes lead to a G2/M phase cell cycle arrest and subsequently induce programmed cell death. The available knowledge on inhibition of AKT phosphorylation, mTOR phosphorylation and Raf down-regulation renders ALPs as attractive candidates for modern medical treatment, which is based on individualized diagnosis and therapy. Corresponding to their unusual profile of activities, their side effects result from cholinomimetic activity mainly and focus on the gastrointestinal tract. These aspects together with their bone marrow sparing features render APCs well suited for modern combination therapy. Although the clinical success has been limited in cancer diseases so far, the use of miltefosine against leishmaniosis is leading the way to better understanding their optimized use.Conclusion:Recent synthetic programs generate congeners with the increased therapeutic ratio, liposomal formulations, as well as diapeutic (or theranostic) derivatives with optimized properties. It is anticipated that these innovative modifications will pave the way for the further successful development of ALPs.
Tetanus Immunity and Epidemiology in Australia, 1993-2010
Authors: Lu Xinting , Quinn Helen E. , Menzies Rob I. , Hueston Linda , McIntyre Peter B. 
Published: October 2018

Background:
This study evaluates trends in tetanus immunity and epidemiology over
the last two decades in Australia, drawing on two national serological surveys and national tetanus
morbidity data, to justify current Australian adult tetanus booster recommendations.

Methods:
We compare tetanus immunity level between two national serosurveys, and examine
incidence trends using the most accurate estimation of the true number of cases by correcting for
under-ascertainment.

Results:
Tetanus immunity in people aged <60 years is high, but the elderly, particularly the female
elderly, may not be adequately protected. Over the past twenty years older people have regularly
accounted for the highest number of tetanus cases, with an increasing proportion of cases.

Conclusion:
Despite a positive decrease in tetanus incidence, there remains a significant burden
in the elderly population of an entirely preventable disease. Supplying a funded booster dose of
dTpa at 65 years would be, potentially, an effective strategy to prevent tetanus cases in Australia.
A Novel Botulinum Toxin TAT-EGFP-HCS Fusion Protein Capable of Specific Delivery Through the Blood-brain Barrier to the Central Nervous System
Authors: Hao Fengjin , Feng Yueqin , Guan Yifu 
Published: October 2018

Objective: Botulinum toxin has many applications in the treatment of central diseases, as
biological macromolecules, it is difficult to pass through the blood-brain barrier which greatly limits
their application. In this paper, we verified whether the botulinum toxin heavy chain HCS has a specific
neural guidance function.

Methods:
We have constructed a fusion protein with botulinum toxin heavy chain and a membrane penetrating
peptide TAT (TAT-EGFP-HCS). Recombinant plasmid of botulinum toxin light chain (LC) and
TAT were also constructed. The biological activity of HCS, LC, TAT-EGFP-HCS and TAT-EGFP-LC
were measured by its ability to cleave protein SNAP-25. The intracellular expression efficiency was
evaluated by detecting the fluorescence intensity of EGFP in the cells by fluorescence microscopy and
FACS. In addition, we also determined the effect of the above plasmid expression on the apoptosis of
PC12 cells. Finally, the tissue specificity of TAT-EGFP-HCS in vivo experiments was also examined.

Results:
In the present study, we have constructed a fusion protein with botulinum toxin heavy chain and
a membrane penetrating peptide TAT which can lead the entire molecule through the blood-brain barrier
and reach the central nervous system. Moreover, we also examined the biological activities of this recombinant
biological macromolecule and its physiological effects on nerve cells in vitro and in vivo.

Conclusion:
TAT-EGFP-HSC expressed in vitro has neural guidance function and can carry large proteins
across the cell membrane without influencing the biological activity.
Bride-Wealth: Is There Respect for Women in Manggarai, Eastern Indonesia?
Authors: Lon Yohanes Servatius , Widyawati Fransiska 
Published: October 2018

This study explores the perspective of women in Manggarai, Flores Island in Indonesia, and the communaltraditional concept of bride-wealth as a symbol of respect for women. This study uses a qualitative approach by interviewing forty women, both married and unmarried. The respondents were asked their opinion regarding their imagination about bride-wealth and its influence on their courtship, engagement, wedding, and married life. The results indicated the presence of a gap between the social imagination of bride-wealth and the women’s true experience. Most respondents stated how bride-wealth had strained their relationship and become a source of worry. The study therefore argues that bride-wealth as a sign of respect for women in Manggarai is merely a social imagination ingrained into the women’s expectations. The study also indicates that education has changed the status of women and enables them to be independent.
Aeroelastic assessment of a highly loaded high pressure compressor exposed to pressure gain combustion disturbances
Authors: Bicalho Civinelli de Almeida Victor , Peitsch Dieter 
Published: October 2018

A numerical aeroelastic assessment of a highly loaded high pressure compressor exposed to flow disturbances is presented in this paper. The disturbances originate from novel, inherently unsteady, pressure gain combustion processes, such as pulse detonation, shockless explosion, wave rotor or piston topping composite cycles. All these arrangements promise to reduce substantially the specific fuel consumption of present-day aeronautical engines and stationary gas turbines. However, their unsteady behavior must be further investigated to ensure the thermodynamic efficiency gain is not hindered by stage performance losses. Furthermore, blade excessive vibration (leading to high cycle fatigue) must be avoided, especially under the additional excitations frequencies from waves traveling upstream of the combustor.
Two main numerical analyses are presented, contrasting undisturbed with disturbed operation of a typical industrial core compressor. The first part of the paper evaluates performance parameters for a representative blisk stage with high-accuracy 3D unsteady Reynolds-averaged Navier-Stokes computations. Isentropic efficiency as well as pressure and temperature unsteady damping are determined for a broad range of disturbances. The nonlinear harmonic balance method is used to determine the aerodynamic damping. The second part provides the aeroelastic harmonic forced response of the rotor blades, with aerodynamic damping and forcing obtained from the unsteady calculations in the first part. The influence of blade mode shapes, nodal diameters and forcing frequency matching is also examined.
Совместная дискретная универсальность дзета-функций Лерха
Authors: Лауринчикас А. , Минцевич А. 
Published: October 2018

После 1975 г. работы Воронина известно, что некоторые дзета и L-функции универсальны в том смысле, что их сдвигами приближается широкий класс аналитических функций. Рассматриваются два типа сдвигов: непрерывный и дискретный.В работе изучается универсальность дзета-функций Лерха L(λ,α,s), s = σ + it, которые в полуплоскости σ > 1 определяются рядами Дирихле с членами e2πiλm(m + α)−sс фиксированными параметрами λ ∈ R и α, 0 < α ≤ 1, и мероморфно продолжаются на всю комплексную плоскость. Получены совместные дискретные теоремы универсальности для дзета-функций Лерха. Именно, набор аналитических функций f1(s),...,fr(s) одновременно приближаются сдвигами L(λ1,α1,s + ikh),...,L(λr,αr,s + ikh), k = 0,1,2,..., где h > 0 - фиксированное число. При этом требуется линейная независимость над полем рациональных чисел множества{(log(m + αj) : m ∈N0, j = 1,...,r), }. Доказательство теорем универсальности использует вероятностные предельные теоремы о слабой сходимости вероятностных мер в пространстве аналитических функций.
О базисах тождеств многообразий группоидов отношений
Authors: Бредихин Д. А. 
Published: October 2018

Множество бинарных отношений, замкнутое относительно некоторой совокупности операций над ними, образует алгебру, называемую алгеброй отношений. Всякую такую алгебру можно рассматривать как упорядоченную отношением теоретико-множественного включения. Для заданного множества Ω операций над бинарными отношениями обозначим через V ar{Ω} [V ar{Ω,⊂}] многообразие, порождённое алгебрами [соответственно упорядоченными алгебрами] отношений с операциями из Ω. Операции над отношениями, как правило, задаются формулами исчисления предикатов первого порядка. Такие операции называются логическими. Важным классом логических операция является класс диофантовых операций. Операция называется диофантовой, если она может быть задана с помощью формулы, которая в своей предваренной нормальной форме содержит лишь операции конъюнкции и кванторы существования. В работе изучаются алгебры отношений с одной бинарной диофантовой операцией, то есть группоиды отношений. В качестве рассматриваемой операции выступает диофантова операция *, определяемая следующим образом: ρ*σ = {( x,у) ∈ X × X : (∃z)( x, z) ∈ ρ∧( x, z) ∈ σ}. Отношение ρ*σ представляет собой результат цилиндрификации пересечения ρ∩σ бинарных отношений ρ и σ. В работе находятся конечные базисы тождеств для многообразий V ar{*} иVar{*,⊂}. Группоид (A, ) принадлежит многообразиюV ar{*} тогда и только тогда, когда он удовлетворяет тождествам: xy = уx (1), (xу)2= xу (2), (xу)у = xу (3), x2у2= x2у (4), (x2у2)z = x2(у2z) (5). Упорядоченный группоид (A,·,≤) принадлежит многообразию V ar{*,⊂} тогда и только тогда, когда он удовлетворяет тождествам (1)–(5) и тождествам: х ≤ x2(6), xу ≤ x2(7). В качестве следствия также получен конечный базис тождеств многообразияVar{*,∪}.
PROSES KREATIF KOMUNITAS SENI NAN TUMPAH
Authors: Eliza Meria , Irianto Ikhsan Satria 
Published: October 2018

AbstrakPenelitian ini bertujuan untuk mengetahui proses kreatif Komunitas Seni Nan Tumpah (KSNT) dan bagaimana persepsi masyarakat terhadap karya dan keberadaannya. KSNT merupakan kelompok seni terproduktif di Sumatra Barat yang karya-karyanya mendapatkan tanggapan berbeda dari masyarakat luas. Upaya untuk mengupas tentang proses kreatif dan keberadaan dari KSNT, metode penelitian yang digunakan adalah pendekatan deskriptif interpretatif. Berdasarkan hasil penelitian dapat diambil kesimpulan, pertama kecenderungan karya KSNT adalah mengolah seni tradisi sebagai material artistik garapan seni modern. Kedua, setiap karya KSNT mempertimbangkan jangkauan penontonnya, sehingga karya-karya KSNT dapat diterima dengan baik oleh masyarakat. Ketiga, keberadaan KSNT meningkatkan minat apresiasi seni masyarakat di Korong Kasai, Padang Pariaman. Kata Kunci: komunitas seni nan tumpah, proses kreatif, masyarakat AbstractThis study aims to find out the creative process of the Komunitas Seni Nan Tumpah (KSNT) and how people's perceptions of their work and existence. KSNT is the most productive art group in West Sumatra whose works get different responses from the wider community. Efforts to explore the creative process and the existence of KSNT, the research method used is interpretive descriptive approach. Based on the results of the study, it can be concluded that the first tendency of KSNT's work is to process traditional art as an artistic material of modern art. Second, each KSNT work considers the audience's reach, so that KSNT's works can be well received by the community. Third, the existence of KSNT increased the interest in the appreciation of community art in Korong Kasai, Padang Pariaman. Keywords: komunitas seni nan tumpah, proses kreatif, masyarakat
Pembangunan Sistem Informasi Zona Potensi Sumber Daya Kelautan Kabupaten Gunungkidul Berbasis HMVC Menggunakan Google Maps API dan JSON
Authors: Susetyo Yerymia Alfa , Saian Pratyaksa Ocsa N. , Somya Ramos 
Published: October 2018

Indonesia dikenal sebagai negara maritim atau kepulauan terbesar di dunia dengan dua per tiga dari luas wilayah Indonesia adalah laut. Sumber daya kelautan dan perikanan Indonesia diperkirakan bernilai US$ 136,5 milyar. Guna meningkatkan nilai ekonomi sumber daya kelautan perlu dirumuskan strategi pengelolaan dengan mengintegrasikan teknologi informasi. Adapun tujuan dari penelitian ini adalah perancangan Sistem Informasi Geografi Zona Potensi Kelautan daerah Kabupaten Gunungkidul, Daerah Istimewa Yogyakarta (DIY) berbasis web sehingga memudahkan pemerintah setempat dalam mengelola informasi tentang potensi pariwisata, pertanian, dan perikanan, dan memudahkan masyarakat umum dalam mencari informasi tentang potensi kelautan di daerah Kabupaten Gunungkidul. Hasil dari penelitian ini adalah web sistem informasi geografi zona potensi kelautan dengan framework CodeIgniter dengan teknologi HMVC (Hierarchical Model View Controller) dan menggunakan servis dari Google Maps API. Aplikasi ini menggunakan format JSON dalam pertukaran data karena memudahkan pengembang dalam mengembangkan aplikasi ke lintas platform.