bluuebunny/crossref_metadata_2025_split huggingface dataset:
Timed Artificial Insemination: Pregnancy Rates in Sokoto Gudali Cattle Treated with Prostaglandin F2 Alpha at a Private Dairy Farm in Nigeria.
Authors: Leigh Olufisayo Oluwadamilare , Mustapha Lukman , Linda Agbugba Chinyere , Ibiam Adaeze Ezenwanyi 
Published: October 2019

Pregnancy rates (PR) resulting from timed artificial insemination (TAI) with frozen semen were investigated in 192 Sokoto Gudali (SG) cattle following estrus synchronization under 11- and 12- day treatment intervals with prostaglandin F2 alpha (Estrumate®). Two-point inseminations at 60 h and 72 h post Estrumate® treatments were used. All cattle were randomly allocated to 2 groups i.e. A and B, such that each sub-group of A1, A2, B1 and B2 had sixteen (16) cows and thirty two (32) heifers. Furthermore, cattle in Groups A and B were administered double Estrumate® injections at 11- and 12-day intervals, respectively. Cattle in sub-groups A1 and B1 were inseminated at 60 h post second Estrumate® injection while A2 and B2 were inseminated at 72 h. Pregnancy was diagnosed using the 60-day non return to estrus and confirmed via rectal palpation at 90 days post insemination. The results showed the following PR: 33%, 83%, 33% and 33% for cattle in sub-groups A1, A2, B1 and B2, respectively. It is concluded therefore that timed artificial insemination at 72 h in SG cattle treated with double Estrumate® injections at 11-day interval produced the best pregnancy rate. These findings raises hope on the future application of TAI in breeding the SG cattle with prostaglandin F2 alpha as single agent of estrus synchronization.
THE IMPLEMENTATION OF GALLERY WALK LEARNING MODEL TO IMPROVE VERBAL COMUNICATING SKILL OF PERFORMANCE RESULT THRU THEMATIC LEARNING
Authors: Pertiwi Candrika Sekar , Lestari Lies , Atmojo Idam Ragil Widianto 
Published: October 2019

<div class="WordSection1"><p><em>The purpose of this research is to improve verbal communicating skill of performance result thru thematic learning in fourth grade students of SD Negeri in Sukoharjo Regency in the academic year of 2017/2018. The method used in this research is Classroom Action Research (CAR) was conducted in two cycles. Each cycle consist of four steps i.e. planning, action, observation, and reflection. The research data was collected by using several techniques such as observation, interview, test, and documentation. The data validity test was using triangulation technique and content validity. The model interactive of analyzing was used on data analyze technique. The assessment result showed both students’ verbal communicating skill and teacher’s performance increased continously. According to the result of this research, implemented Gallery Walk learning model can improve verbal communicating skilll of performance result thru thematic learning for 4th grade students of SD Negeri in Sukoharjo Regency in the academic year of 2017/ 2018.</em></p></div>
IMPROVING FRACTION OPERATION SKILLS OF MULTIPLICATION AND DIVISION THROUGH THE APPLICATION OF DOMINO CARD TO STUDENT OF GRADE V SDN 02 PULOSARI ACADEMIC YEAR 2017/2018.
Authors: Retnowati Rohmatul Putri , Kamsiyati Siti , Matsuri Matsuri 
Published: October 2019

<p>This research is focusing about using domino card as media that improve the skills of multiplication counting operations and fractional division in the students of class V SDN 02 Pulosari academic year 2017/2018.The objectives of this research is to improve the skills of multiplication counting and fractional division by applying the domino card media to the students of class V SDN 02 Pulosari academic year 2017/2018.This research method is Classroom Action Research with two cycles. Every consists of planning, execution, action, observation and reflection. Subjects in this study were students of grade 5<sup>th</sup> SDN 02 Pulosari which consisting 25 students. The data sources are primary data sources and secondary data sources. Data analysis technique is comparative descriptive analysis technique.The study produce an average of thevalue of pra sycle skills action fraction is 61,1 with completeness 28%. First sycle is 71,9 as reference for classical completeness with 44% source data and the average value of fractional counting operation skills of second sycle is 81.9 with a percentage of mastery of 80%. Based on the results of this study can be concluded that the use of domino card media can improve the skills of multiply counting operations and fractional divisions in students of class V SDN 02 Pulosari.</p>
IMPROVEMENT OF POETRY WRITING SKILL THROUGH AUDITORY, INTELLECTUALLY, REPETITION (AIR) BASED ON OUTDOOR STUDY (Classroom Action Research of Third Grade at SD Negeri Soropadan No. 108 Surakarta Academic Year 2017/2018)
Authors: Proborini Proborini , Winarni Retno , Lestari Lies 
Published: October 2019

<p>The aim of this research to improve poetry writing skill through Auditory, Intellectually, Repetition (AIR) based on Outdoor Study for third grade students at SD Negeri Soropadan 108 Surakarta academic year 2017/2018. This research form was Classroom Action Research. It conducted by two cycles. Each cycle consist of planning, acting, observing, and reflecting. Data collection technique used interview, observation, test, and documentation. Data validity technique used content validity, resources triangulation, and technique triangulation. Data analysis technique consisted by data collection, data reduction, data display, and conclusion. The result of this research indicated improvement of poetry writing skill of third grade students at SD Negeri Soropadan 108 Surakarta academic year 2017/2018 from preaction 29,73%, cycle I 54,05%, and cycle II 89,19%. The conclusion of this research indicated that through Auditory, Intellectually, Repetition (AIR) based on Outdoor Study can improve student writing skill of third grade students at SD Negeri Soropadan 108Surakarta academic year 2017/2018.</p>
‘ENAK’ BALL AS A ENVIRONMENTALLY FRIENDLY MULTISENSORIAL GAME TOOLS
Authors: Fadhilah Nurul , Rahmawati Yuyun , Novitasari Wahyuni , Khamdani Faisal 
Published: October 2019

<p>Media pembelajaran anak usia dini sangat penting untuk Optimalisasi Tumbuh Kembang Anak, oleh karena itu berbagai media pembelajaran sangat diperlukan oleh para pendidik, praktisi PAUD, serta pemerhati Pendidikan Anak usia Dini lainnya ketika melaksanakan program pendidikan. Salah satu media yang dipergunakan untuk program pendidikan pada anak usia dini bersifat multisensori dan ramah lingkungan yaitu bola ENAK. Berdasarkan survei serta observasi tidak langsung terhadap analisis kebutuhan yang dilakukan penulis terhadap para pendidik dan pemerhati PAUD diperoleh informasi, bahwa: 1) Para Pendidik dan permerhati PAUD sepakat jika dilakukan upaya pengadaan media pembelajaran yang lebih atraktif, multifungsi, multisensori dan ramah lingkungan sehingga dapat digunakan sebagai alternatif yang konstruktif dan variatif sebagai media pembelajaran yang menyenangkan; 2) 100% pendidik dan pemerhati PAUD menyetujui bahwa pengembangan media bola dilakukan lebih beragam fungsi, tekstur dan bahan yang digunakan. Penulis melakukan berbagai upaya sebagai berikut : 1) Pengadaan Bola ENAK yang dimodifikasi meliputi 9 varian terdiri dari <em>Phonetic</em> <em>Ball, Numeric Ball, Shape Ball, Expression Ball, Musical Ball, FF Ball, Texture Ball, Calour Ball, Reliqius Ball</em>; 2) Menganalisis kebutuhan para pendidik dan pemerhati PAUD umum; 3) Menyusun rancangan produk awal; 4) Mengembangkan media Bola ENAK serta Uji Ahli; 5) Melakukan revisi produk; 6) Menghasilkan <em>finising</em> Bola ENAK sebagai model akhir; 7) Melakukan marketing keberbagai sasaran. Media Bola ENAK sebagai alat permainan multisensori yang ramah lingkungan dapat dijadikan media pembelajaran pada anak usia dini lebih inovatif.</p>
THE RELATIONSHIP BETWEEN READING SPEED AND READING COMPREHENSION IN INDONESIAN SUBJECTS IN V GRADE ELEMENTARY SCHOOL
Authors: Badriyah Siti , Yuliana Rina 
Published: October 2019

<pre><em>This study aims to determine relationship of reading to understanding readings in indonesian class v academic year 2017/2018. The method used in this research is quantitative descriptive method with correlational technique and sampling is done by random sampling technique. Technique of data collection is done through observation sheet and oral test about reading comprehension comprehension. Based on the data analysis obtained correlation coefficient in this study is 0,129 and included into very low category. The number indicates that the correlation is positive. Meanwhile, the coefficient of determination obtained is 1.6641%. These results indicate that the magnitude of the contribution of students' reading speed to the reading comprehension of students is 1.6641%. Result of correlation significance test at significant level α = 0,05 obtained t<sub>count</sub> = 0,596 and t<sub>table</sub> = 1,721. So it can be concluded that there is a positive relationship between the speed of reading to understanding reading but not significant.</em></pre>
ANALYSIS OF CHARACTER VALUES THROUGH ITP AND ATP TECHNOLOGY AS ONE OF THE INNOVATIONS IN LEARNING ELEMENTARY SCHOOL EDUCATION TO OVERCOME DEGRADATION
Authors: Vonna Cut Nurul Zara , Retnoningrum Fenti , Sari Indah Novita , Chamdani Muhamad 
Published: October 2019

<em>The development of time because of the existence of globalization led to moral degradation in children. To overcome the moral degradation of the child, it is necessary to have learning innovations in improving the quality of basic education which requires an analysis of character education using methods of observation and questionnaire by entering the results of analysis into ITP software (Development Task Inventory) and ATP (Analysis of Development Task). The existence of ITP and ATP can identify the level of development of aspects related to character education in primary school. Based on preliminary observations, it was found that many teachers did not know the level of children's character development. The article aims to: (1) educators can identify the level of students character (2) educators can design good learning based on the results of each student's character analysis. The conclusion of this study is that educators can develop children's character levels.</em>
COMIC LEARNING MEDIA DEVELOPMENT IN EFFORTS TO GROW LITERACY CULTURE AND ENVIRONMENTAL CARE ATTITUDE FOR ELEMENTARY SCHOOL STUDENT
Authors: Lana Syifa' , Rahman Rifqi Aulia , Widodo Rudi Danang 
Published: October 2019

<p><em>This research was aimed to describe the science comic design with </em><em>the environmental care theme as a learning medium for developing the literacy culture and environmental care attitude for elementary school students</em><em>. Research and Development (R &amp; D)</em><em> approach was implemented by utilizing 4D models which was limited to the Develop stage only</em><em>.</em><em> The comic media was reviewed and assessed by an expert of media, a linguist, an expert of material, and three elementary school teachers.</em><em>. </em><em>The data were collected by using observation technique and questionnaire. The results showed that the comic science media with the theme of environmental care can be used as a learning medium that can develop a culture of literacy and attitudes of environmental care in primary schools based on the contents of the curriculum standard 2013. The quality result of the assessment from the expert and the student response indicated a good category.</em><em></em></p>
THE INFLUENCE OF SEX TOWARD THE COMPREHENSION READING ABILITY OF CLASS V STUDENTS IN THE ELEMENTARY SCHOOL OF PANJER VILLAGE
Authors: Sandhi Dwi Pungky Ari , Karimizzah Diyani Ayu , Monitasari Diah , Suhartono Suhartono 
Published: October 2019

<p><em>Reading is a skill needed to get knowledge. To understand the contents of a reading, it is necessary to have comprehension reading ability. Faktors that influence the reading comprehension ability are physiological, intellectual, environmental and psychological faktors. Physiological faktors include physical health, neurological consizderations and sex. The focus of this research is on the influence of sex. This research uses a correlational method in which the populations used are fifth grade students of primary schools in Panjer village, Kebumen district with a sample of 4 classes from 4 elementary schools. The results of this research indicate that female students have better comprehension reading ability than male students.</em></p>
PROBLEMS WITH THE 2013 CURRICULUM CHANGE ON THE QUALITY OF TEACHER TEACHING
Authors: Pramesti Wahyu , Permatasari Mauliddhina Imas , Chamdani Muhamad 
Published: October 2019

<p><em>Curriculum always develops following the current times. the change of curriculum implementation encountered many obstacles both from schools, teachers and students. . This research is a qualitative descriptive study. Data collection techniques used are questionnaires. this research aims to identify the problems of teachers in implementing the 2013 curricullum learning in elementary schools. this research is expected can give useful information about the 2013 curriculum problem on how the way the teacher teaches to improve the teaching learning qualityThe results of the study show that the problems of teachers come from the government, teachers, and students. The problems of the teacher include learning media, learning materials, learning methods, and the integration of the lessons learned in thematic learning. Students' problems are adaptation to thematic learning in the 2013 curriculum. The conclusion is that the implementation of the 2013 curriculum with good teacher quality can improve learning in school.</em></p>
Down-regulation of NAMPT expression by miR-154 reduces the viability of breast cancer cells and increases their susceptibility to doxorubicin
Authors: Bolandghamtpour Zahra , Nourbakhsh Mitra , Mousavizadeh Kazem , Madjd Zahra , Ghorbanhosseini Seyedeh Sara , Abdolvahabi Zohreh , Hesari Zahra , Ezzati Samira 
Published: October 2019

Abstract
Background
Nicotinamide phosphoribosyltransferase (NAMPT) acts as an important enzyme in the salvage pathway of nicotinamide adenine dinucleotide (NAD) biosynthesis. Deregulation of NAD could be associated with progression of many cancers including breast cancer. Here, we evaluated the effect of NAMPT inhibition via miR-154 on survival of breast cancer cells.
Methods
Breast cancer cell lines including MCF-7 and MDA-MB-231 were transfected with miR-154-5p mimic, inhibitor and their negative controls. Using real-time PCR and western blotting techniques the expression levels of NAMPT and miR-154 were determined and compared with the untreated cells. NAD levels were measured by an enzymatic method. Subsequently, colorimetric methods and flow cytometry were performed to evaluate cell viability and apoptosis. Bioinformatics analyses were performed to investigate whether NAMPT 3′-UTR is a direct target of miR-154 and the findings were confirmed by luciferase reporter assay.
Results
According to the obtained results, NAMPT 3′-UTR was identified as a direct target of miR-154 and the levels of this miRNA was inversely associated with NAMPT expression both at mRNA and protein levels in breast cancer cell lines. Functionally, miR-154 inhibited the NAD salvage pathway leading to a remarkable decrease in cell survival and induction of apoptosis. Co-treatment of breast cancer cells with doxorubicin and miR-154 mimic significantly reduced cell viability compared to treatment with doxorubicin alone in both cell lines.
Conclusions
Hence, it was concluded that the inhibition of NAD production by miR-154 might be introduced as a promising therapeutic strategy for the treatment of breast cancer either alone or in combination with other conventional chemotherapeutic agents.
RNA 3D structure prediction guided by independent folding of homologous sequences
Authors: Magnus Marcin , Kappel Kalli , Das Rhiju , Bujnicki Janusz 
Published: October 2019

Abstract
Background

The understanding of the importance of RNA has dramatically changed over recent years. As in the case of proteins, the function of an RNA molecule is encoded in its tertiary structure, which in turn is determined by the molecule's sequence. The prediction of tertiary structures of complex RNAs is still a challenging task.

Results

Using the observation that RNA sequences from the same RNA family fold into conserved structure, we test herein whether parallel modeling of RNA homologs can improve ab initio RNA structure prediction method. EvoClustRNA is a multi-step modeling process, in which homologous sequences for the target sequence are selected using the Rfam database. Subsequently, independent folding simulations using Rosetta FARFAR and SimRNA are carried out. The model of the target sequence is selected based on the most common structural arrangement of the common helical fragments. As a test, on two blind RNA-Puzzles challenges, EvoClustRNA predictions ranked as the first of all submissions for the L-glutamine riboswitch and as the second for the ZMP riboswitch. Moreover, through a benchmark of known structures, we discovered several cases in which particular homologs were unusually amenable to structure recovery in folding simulations compared to the single original target sequence.

Conclusion

This work, for the first time to our knowledge, demonstrates how important is the selection of the target sequence from an alignment of an RNA family for the success of RNA 3D structure prediction. These observations prompt investigations into a new direction of research for checking 3D structure “foldability” or “predictability” of related RNA sequences to obtain accurate predictions. To support new research in this area, we provide all relevant scripts in a documented and ready-to-use form. By exploring new ideas and identification of limitations of the current RNA 3D structure prediction methods, this work is bringing us closer to the near-native computational RNA 3D models.
Effects of Depression, Dementia and Delirium on Activities of Daily Living in Elderly Patients after Discharge
Authors: Weng Ching Fu , Lin Kun-Pei , Lu Feng-Ping , Chen Jen-Hau , Wen Chiung-Jung , Peng Jui-Hua , Tseng Ailun Heather , Chan Ding-Cheng 
Published: October 2019

Abstract
Background
The three geriatric conditions, depression, dementia and delirium (3D’s), are common among hospitalized older patients and often lead to impairments of activities of daily living. The aim of this study is to explore the impact of depression, dementia and delirium on activities of daily living (ADLs) during and after hospitalization.
Methods
A prospective cohort study was conducted between 2012 and 2013 in a tertiary medical center in Taiwan. Patients aged 65 years and older admitted to the geriatric ward were invited to this study. Geriatric Depression Scale Short Form, Mini-Mental State and Confusion Assessment Method were used to identify patients with depression, dementia and delirium on admission, respectively. Barthel Index (BI) was used to evaluate patients’ functional status on admission, at discharge, 30-day, 90-day and 180-day after discharge. Generalized Estimating Equation was used to calculate the associations between 3 D’s and BI.
Results
One-hundred-and-forty-nine patients were included in this study. Twenty-seven patients (18.1%) had depression, 37 (24.8%) had dementia, and 85 (57.0%) had delirium. There were significant lower BI scores in patients with dementia and delirium compared with those without up to 180 days after discharge, but no difference was seen in the depression group. In general, patients had delirium or dementia had worsening functional status, even though significant magnitude of improvements on BI scores after discharge.
Conclusions
Depression does not affect patients’ ADLs. On the other hand, dementia and delirium can persistently limit patients’ physical function. Future care should focus more on dementia and delirium to restore function.
Lack of Impact of Nil-Per-Os (NPO) Time on Goal-Directed Fluid Delivery in First Case versus Afternoon Case Starts: A Retrospective Cohort Study
Authors: Field R Ryan , Mai Tuan , Hanna Samouel , Harrington Brian , Calderon Michael-David , Rinehart Joseph 
Published: October 2019

Abstract
Background: Goal Directed Fluid Therapy(GDFT) represents an objective fluid replacement algorithm. The effect of provider variability remains a confounder. Overhydration worsens perioperative morbidity and mortality; therefore, the impact of the calculated NPO deficit prior to the operating room may reach harm.
Methods: A retrospective single-institution study analyzed patients at UC Irvine Medical Center main operating rooms from September 1, 2013 through September 1, 2015 receiving GDFT. The primary study question asked if GDFT suggested different fluid delivery after different NPO periods, while reducing inter-provider variability. We created two patient groups distinguished by 0715 surgical start time or start time after 1200. We analyzed fluid administration totals with either a 1:1 crystalloid to colloid ratio or a 3:1 ratio. We performed direct group-wise testing on total administered volume expressed as total ml, total ml/hr, and total ml/kg/hr between the first case start (AM) and afternoon case (PM) groups. A linear regression model included all baseline covariates that differed between groups as well as plausible confounding factors for differing fluid needs. Finally, we combined all patients from both groups, and created NPO time to total administered fluid scatterplots to assess the effect of patient-reported NPO time on fluid administration.
Results: Whether reported by total administered volume or net fluid volume, and whether we expressed the sum as ml, ml/hr, or ml/kg/hr, the AM group received more fluid on average than the PM group in all cases. In the general linear models, for all significant independent variables evaluated, AM vs PM case start did not reach significance in both cases at p=0.64 and p=0.19, respectively. In scatterplots of NPO time to fluid volumes, absolute adjusted and unadjusted R2 values are < 0.01 for each plot, indicating virtually non-existent correlations between uncorrected NPO time and fluid volumes measured.
Conclusions: This study showed NPO periods do not influence a patient’s volume status just prior to presentation to the operating room for surgical intervention. We hope this data will influence the practice of providers routinely replacing calculated NPO period volume deficit; particularly with those presenting with later surgical case start times.
Assessing the prevalence and risk factors of pre-diabetes among the community of Iganga Municipality, Uganda: A cross sectional study
Authors: Aramo Christine , Oyom Anthony Peter , Okello Emmanuel , Acam Victoria , Okiria John Charles , Mwambi Bashir , Oyet Caesar 
Published: October 2019

Abstract
Objective: The prevalence of pre-diabetes is increasing globally with more than 470 million people projected to develop pre-diabetes by 2030. In Africa, the average prevalence of pre-diabetes was estimated at 7.3% in 2015 and affected individual will develop type 2 diabetes mellitus within few decades. The aim of the study was to determine the prevalence of pre-diabetes and associated risk factors among residents of Iganga Municipality. A cross-sectional study was conducted among males and females aged 13-60 years. District health office provided updated household list from which sampling of the villages was performed based on probability proportionate to population. Consented participants were prepared for the study, allowing fasting for 8 to 10 hours before blood collection the next morning. Individuals with impaired fasting glucose, were subjected to OGTT. Results: 130 participants were enrolled, of which 98 were women. The mean age of the participants was 35 years. The prevalence of pre-diabetes was 3.8%. The proportion of impaired glucose tolerance was higher in current smokers (p = 0.01), obese participants (p = 0.002) and hypertensives (p <0.001). Prevalence of pre-diabetes is high in this community and is associated with current smoking, hypertension and high BMI.