bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water quality assessment of an urban river receiving tail water using the single-factor index and principal component analysis
Authors: Lu Weiwei , Wu Juan , Li Zhu , Cui Naxin , Cheng Shuiping 
Published: June 2018

Abstract
Tail water from wastewater treatment plants (WWTP) serves as a major supplementary water source for scenic water bodies, whose water quality is one of the major focuses of public and scientific inquiries. This study investigated the temporal and spatial variations in water quality of Tangxihe River, a eutrophic urban river receiving tail water from a nearby WWTP in Hefei City, using the single-factor index (SFI) and principal component analysis (PCA). The results of SFI indicated that the most important parameters responsible for low water quality were total nitrogen (TN) and ammonia (NH4+-N). PCA showed that tail water from the WWTP greatly reduced water quality, as demonstrated by the significantly increased SFIs and integrated principal component values (F values) of the sampling points around the drain outlet of the WWTP (T3, T4 and T5). The sampling points located at the upstream of the river (T1) and up the water-gate of Chaohu Lake (T6) had negative F values, indicating relatively higher water quality. In addition, the season had a significant effect on the water quality of the river. Moreover, we discuss measures to improve the water quality of urban rivers in order to maintain their ecological functions.
Onion and Garlic Extracts Potentiate the Efficacy of Conventional Antibiotics against Standard and Clinical Bacterial Isolates
Authors: Mahomoodally Fawzi , Ramcharun Simla , Zengin Gokhan 
Published: June 2018

Introduction: Onion (Allium cepa L.) and garlic (Allium sativum L.) extracts are traditionally
used in many cultures as antimicrobial agents. Nonetheless, there is still a dearth of scientific validation
pertaining to the antibacterial and possible antibiotic potentiating activity of these plants.

Methods:
Decoction as traditionally used and methanol, ethanol, ethyl acetate, and acetone extracts of
onion and garlic were evaluated for their antibacterial activity against 15 bacterial strains (6 ATCC
strains and 9 clinical isolates) using the broth microdilution method to establish the minimum inhibitory
concentration. The bacteriostatic and bactericidal actions were determined as compared to conventional
antibiotics (streptomycin and chloramphenicol). Fractional Inhibitory Concentration (FIC) was determined
to establish any synergistic interaction between the extracts and antibiotics using a modified
checkerboard assay.

Results:
The ethyl acetate extract of garlic showed bactericidal effect against 1 ATCC (E. coli) and 2
clinical isolates. Streptomycin produced only indifferent effect (FIC 1< and ≤ 4) when combined with
ethyl acetate extract of onion. Chloramphenicol showed synergism with ethyl acetate extract of onion
against ATCC S. aureus (FIC 0.27-0.30) and Micrococci species (FIC 0.27-0.32). Streptomycin showed
mostly antagonism whereas chloramphenicol showed synergism effects with the ethyl acetate extract of
garlic. The observed antibacterial activity might be justified due to the presence of high concentration of
phenolic compounds in the extracts.

Conclusion:
This study has provided an opportunity to establish valuable baseline information on the
antibiotic potentiating activity of onion and garlic which can be further exploited for the treatment
and/or management of infectious diseases.
Comparison of Triflusal with Aspirin in the Secondary Prevention of Atherothrombotic Events; Α Randomised Clinical Trial
Authors: Kalantzi Kallirroi I. , Ntalas Ioannis V. , Chantzichristos Vasileios G. , Tsoumani Maria E. , Adamopoulos Dimitrios , Asimakopoulos Christos , Bourdakis Adamantios , Darmanis Petros , Dimitriadou Alexandra , Gkiokas Stefanos , Ipeirotis Konstantinos , Kitikidou Kyriaki , Klonaris Ioannis , Kostaki Aglaia , Logothetis Dimitrios , Mainas Konstantinos , Mais Theodoros , Maragiannis Athanasios , Martiadou Konstantina , Mavronasos Konstantinos , Michelongonas Ioannis , Mitropoulos Dimitrios , Papadimitriou Georgios , Papadopoulos Achilleas , Papaioakeim Miltiadis , Sofillas Kosmas , Stabola Sotiria , Stefanakis Emmanouil , Stergiou Dimitrios , Thoma Maria , Zenetos Alexandros , Zisekas Stergios , Goudevenos John A. , Panagiotakos Demosthenes B. , Tselepis Alexandros D. 
Published: June 2018

Background:
Triflusal has demonstrated an efficacy similar to aspirin in the prevention of
vascular events in patients with acute myocardial infarction (ΜΙ) and ischaemic stroke but with less
bleeding events.

Objective:
We performed a randomised, multicentre, phase 4 clinical trial to compare the clinical efficacy
and safety of triflusal versus aspirin, administered for 12 months in patients eligible to receive a
cyclooxygenase-1 (COX-1) inhibitor.

Methods:
Patients with stable coronary artery disease or with a history of non-cardioembolic ischaemic
stroke were randomly assigned to receive either triflusal 300 mg twice or 600 mg once daily or aspirin
100 mg once daily for 12 months. The primary efficacy endpoint was the composite of: (a) ΜΙ, (b)
stroke (ischaemic or haemorrhagic), or, (c) death from vascular causes for the entire follow-up period.
The primary safety endpoints were the rate of bleeding events as defined by Bleeding Academic Research
Consortium (BARC) criteria.

Results:
At 12-month follow-up, an equivalent result was revealed between the triflusal (n=559) and
aspirin (n=560) in primary efficacy endpoint. Specifically, the combined efficacy outcome rate (i.e. MI,
stroke or death from vascular causes) difference was equal to -1.3% (95% confidence interval -1.1 to
3.5) and lied within the a-priori defined equivalence interval (p<0.001). Regarding the primary safety
endpoints, patients on triflusal treatment were 50% less likely to develop bleeding events according to
the BARC criteria, and especially any clinically overt sign of haemorrhage that requires diagnostic studies,
hospitalisation or special treatment (BARC type 2).

Conclusion:
The efficacy of triflusal in the secondary prevention of vascular events is similar to aspirin
when administered for 12 months. Importantly, triflusal significantly reduced the incidence of ΜΙ and
showed a better safety profile compared with aspirin.

:
(ASpirin versus Triflusal for Event Reduction In Atherothrombosis Secondary prevention, ASTERIAS
trial; Clinical Trials.gov Identifier: NCT02616497).
Mechanisms Enhancing the Cytotoxic Effects of Bleomycin plus Suicide or Interferon-β Gene Lipofection in Metastatic Human Melanoma Cells
Authors: Fondello Chiara , Agnetti Lucrecia , Glikin Gerardo C. , Finocchiaro Liliana M.E. 
Published: June 2018

Background:
Three metastatic human melanoma cell lines generated from patient removed lymph
nodes and spleen metastasis were established in our laboratory.

Objective:
To investigate the mechanisms enhancing the cytotoxic effects of Bleomycin (BLM), herpes simplex
virus thymidine kinase/ganciclovir Suicide Gene (SG) and human interferon-β gene (hIFNβ) lipofection in early
passages of these melanoma cell lines.

Methods:
In these cell lines, we determined: cytotoxicity, bystander effect, lipofection efficiencies, apoptosis,
necrosis, senescence, colony forming capacity and mitochondrial membrane depolarization after treatments.

Results:
The three assayed cell lines displayed sensitivity to single and combined BLM/gene treatments. BLM
improved the antitumor and anti-clonogenic effects of SG and hIFNβ genes. Considering the low lipofection
efficiencies (<10%), one of the main causes of the SG and hIFNβ gene effectiveness was their bystander effect.
In one of these cell lines, this effect eradicated up to 60% of the cells although <1% expressed the transgene. In the
three cell lines, BLM alone or combined with SG or hIFNβ gene significantly increased the percentage of cells
exhibiting membrane compromise, DNA damage, and senescence. Interestingly, the strong BLM/hIFNβ gene
combination was able to generate from 73% to 98% of non-viable cells. The high proportion of senescent cells
induced by BLM alone or combined with genes strongly decreased the clonogenic capacity of surviving cells.

Conclusion:
The presented results indicate that BLM improves the antitumor effects of SG and hIFNβ transgene
expression. Altogether, these findings strongly support the clinical potential of these combined approaches.
Peniciketal A, A Novel Spiroketal Compound, Exerts Anticancer Effects by Inhibiting Cell Proliferation, Migration and Invasion of A549 Lung Cancer Cells
Authors: Gao Xue , Zhou Yuming , Zheng Xiaoqi , Sun Hongliu , Zhang Jing , Liu Weizhong , Pan Xiaohong 
Published: June 2018

Background:
Peniciketal A (Pe-A) is a spiroketal compound isolated from saline soil-derived fungus
Penicillium raistrickii. However, its role for biological processes has not been clarified. In this study, we for the
first time investigated the anticancer effects and the underlying mechanisms of Pe-A in A549 lung cancer cells.

Metheds:

Cell proliferation was tested by MTT assay and colony formation assay. Flow cytometry was performed
to examine the cell cycle, apoptosis and mitochondrial membrane potential. Invasion and migration were
analyzed using transwell assay and wound healing analysis. Immunofluorescence staining and western blotting
were used to evaluate the protein expression.

Results:
Pe-A effectively inhibited proliferation, with IC50 values was 22.33 μM for 72 h. Mechanistic studies
revealed that Pe-A caused cell cycle arrest at the G0-G1 phase by decreasing cyclinD1 expression and induced
apoptosis through accelerating the mitochondrial apoptotic pathway. Moreover, Pe-A significantly inhibited
A549 cell migration and invasion by reducing the protein levels of MMP-2 and MMP-9, while the Epithelial-
Mesenchymal Transition (EMT) property was also changed. Importantly, Pe-A exhibited much lower toxicity
towards L02, normal liver cells, and MRC5, normal fibroblast cells, compared to A549 cells.

Conclusion:
Collectively, the current results indicate that Pe-A may offer effective potentials and insights for
lung cancer treatment and drug design.
New Approaches for the Uses of Cyclohexan-1,4-dione for the Synthesis of 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-b]pyridine Derivatives used as Potential Anti-prostate Cancer Agents and Pim-1 Kinase Inhibitors
Authors: Mohareb Rafat M. , Abdo Nadia Y. Megally , EL-Sharkawy Karam A. 
Published: June 2018

Background:
Among the wide range of heterocycles, tetrahydrobenzothienopyridine derivatives
acquired a special attention due to their wide range of pharmacological activities especially the therapeutic activities.
Many pharmacological drugs containing the thiophene nucleus were known in the market.

Method:
A series of tetrahydrobenzothienopyridine derivatives were synthesized from the reaction of 2-amino-
3-benzoyl-4,5-dihydrobenzo[b]thiophen-6(7H)-one, synthesized and used for further heterocyclization reactions
through reaction with different reagents.

Results:
Antiproliferative evaluations and c-Met kinase, Pim-1 kinase inhibitions were performed where some
compounds revealed high activities.

Conclusion:
The inhibition of the newly synthesized compounds towards c-Met kinase, the five c-Metdependent
cancer cell lines (A549, HT-29, MKN-45, U87MG, and SMMC-7721) and one c-Met-independent
cancer cell line (H460) were investigated using foretinib as a standard drug. The results showed that compounds
6b, 7e, 9b, 9e, 16c and 20d were more active than foretinib. Furthermore, compounds 6b, 13b, 16b and 16c were
selected to examine their Pim-1 kinase inhibition activity, where compounds 16b and 16c were of high potencies
with IC50 values of 0.28 and 0.32 µM, while compounds 6b and 13b were less effective (IC50 > 10 µM).
Bioscaffolds in Periodontal Regeneration
Authors: Varghese Jothi , Mohan Rudra 
Published: June 2018

Background:
Tissue engineering is a highly evolving field in periodontology which incorporates
the use of cells, signalling molecules and scaffolds thereby creating a three dimensional microenvironment
facilitating cellular growth and function for restoration of lost tissues due to periodontal disease.
This review discusses the various types, ideal characteristics, properties and applications of potential
scaffolds that can be used in periodontal regeneration with the help of principles of tissue engineering.

Methods:
Research work pertaining to bioscaffolds for periodontal regeneration were selected using key
words in major databases and internet sources.

Results:
Studies related to various features of scaffold and its inherent properties were searched and analysed.
Data were organized considering the sources of its origin and salient features of these inert matrices.
Specific probe into the techniques and medium used for developing scaffolds were cited. Further,
bioactive ceramic materials which are involved in stimulating cell proliferation, and bone tissue regeneration,
which may also facilitate periodontal regeneration were mentioned. Likewise, few data linked
to different types of biodegradable synthetic scaffolds and its advantages were considered. The progress
of science in various fabrication techniques and newer advances using modern technology such as tissue
engineering approaches, 3D printing and physical & chemical methods to enhance the physical properties
are being used to make them more versatile for the application in the field of biomedical science.

Conclusion:
In lieu of the available literature search and vast progress in material science, scaffolds
construction for cellular regeneration requires wide exploration. Furthermore, when these scaffolds are
placed at a particular site, it should be able to restore lost periodontal tissue. Also, the newer innovative
technologies like the 3D version of biomimicking, nano/micro-based scaffolds displays potential for further
extensive research and complete regeneration of periodontal tissues.
Study of Measurement Techniques for Strong Pulsed Magnetic Field
Authors: Li Zhenhua , Li Qiuhui , Qiu Li , Xiong Qi , Deng Changzheng 
Published: June 2018

Background:
Currently, how to measure the magnetic field accurately is a difficulty in the
study of strong magnetic field.

Methods:
This paper summarizes several methods of measurement techniques for strong pulsed magnetic
field presently, the principles and characteristics of various measurement methods are compared
and analyzed. The maximum measurement intensity of electromagnetic induction method can reach
103T. The magneto-optical effect method of Faraday can measure the magnetic field intensity of
0.1~10T, and the measurement error is within 10-2T.

Results:
The MOKE effect can measure a magnetic field intensity up to 100T, with an error 3×10-2T.
The Zeeman effect can be measured in a magnetic field intensity of 1~20T.

Conclusion:
The existential problems of various methods are described. Lastly, some solutions are proposed
according to the existential problems, and the development of measurement techniques for strong
pulsed magnetic field in the future is prospected.
A PRIMER ON BIOINFORMATICS
Authors: ADEBO PHILIP 
Published: June 2018

ABSTRACT Today biological research is experiencing explosive growth in academic, industry, and government sectors. Bioinformatics has emerged to make sense of such high volume and complex data. It is an interdisciplinary field that combines computer science, biology, engineering, and mathematics in order to develop methods, techniques, and tools for analyzing and interpreting biological data. It uses computational approaches to solve complex biological problems and analyze large-volume of biological data. This paper provides a primer on bioinformatics.
A Study of Bluetooth Wireless Technology Using Recent Attacks
Authors: Gautam Shivangi , Pandey Ashutosh , Khan Rizwan 
Published: June 2018

Bluetooth is a wireless technology that is used for the exchange of information over a network for short separations. It is a low controlled, short range application. It utilizes Bluetooth to convey to other Bluetooth-empowered gadgets because it is a communication protocol. Bluetooth resembles some other correspondence convention that you utilize each day, for example, HTTP, FTP, SMTP, or IMAP. Bluetooth is designed to connect with monitor and mouse without any connection with CPU. Different kinds of Bluetooth gadgets are headsets, Bluetooth prepared printer, in-auto Bluetooth framework, Bluetooth gps framework, Bluetooth console, Bluetooth prepared webcam and so on. Bluetooth advancement tends to an open entryway for the business to pass on remote arrangements that are unavoidable over an expansive scope of gadgets. The constraints and properties of Bluetooth scatter presents remarkable troubles in framing a system in which all devices communicate with each other directly. In this paper, detailed description of Bluetooth along with its working is given. Description also includes connection protocols of the Bluetooth, usage models, advantages and dis-advantages. Further, various applications of the Bluetooth wireless technology are portrayed.
A Review on Biometric Technology
Authors: Choudhary Kartik , Khan Rizwan 
Published: June 2018

Biometric Technology has turned out to be a popular area of research in computer vision and one of the most successful applications for identifying humans by capturing and analysing the sole feature or characteristic of individual which is possessed by them and involves their Physical and Behavioral characteristics. For the individual validation and authentication the biometric system has this responsibility. Biometric Technology started from the fingerprints recognition and later on improvements were done in it to make it more secure which involves the face recognition and iris Recognition. Almost both of them are available and regarded as the accurate and reliable technology for biometric validation system. This review paper is all about Face recognition techniques in biometric locking system and Iris recognition technique of identification and the ways of making locking systems ways more efficient, full of ease, more secure, and far better than before so as to make locking or security stronger. It discusses about face recognition technique, its working and its application in different sector along with iris recognition, its working, its application.
A Review on Information Security
Authors: Kaushal Priyanka , Khan Rizwan 
Published: June 2018

In now days the concept of the Information risks and Security is becoming a fast-moving discipline. In now days thesystems are assembled on different machines belongsto the same principals with the different interests, information of different machines are now becoming as important to depend on technical design. The information security not only provides the ‘security’ topics such as data loss prevention, bugs, data breaches, spam, and phishing, but also in many other areas such as system dependability (person-to-person design and efforts by testers and programmer)t, and policy (the rights of management). Main aim of this research program has been starting to think over more general security questions (such as law-enforcement strategy, performance), and also the interface between security and the computer sciences. Most commonly and recently the more concern of information security is due to various Information risk. This paper provides you the overview about how we secure our data and our information from unauthorized personsand from hackers. For the practice the various organization will choose many method to overcome the problem of information risk. The promise of this research program is to aware you about the information related risks and how to cope with that.
Penggunaan Media Sosial oleh <i>Digital Native</i>
Authors: Supratman Lucy Pujasari 
Published: June 2018

The lack of digital media literacy education shall become requirement to the rises of horribly phenomenon in Indonesia. The purpose of this study is to create the awareness on using social media smartly. I used qualitative method that had been taken through purposive sampling. Since the Collaborative Learning Model of Digital Media Literacy was applied, students mindset about Digital Media Literacy meaning had shifted into the wiser social media users.
Asbestos in automotive waste. Contemporary recycling methods of waste from automotive industry
Authors: Wójcik Marta 
Published: June 2018

Increasing requirements concerning the environmental protection and waste management result in the development both new and effective recycling methods of various fractions of waste. From the technical and natural sciences point of view, the utilization of hazardous waste is essential. The inappropriate utilization of hazardous waste causes the environmental degradation. Particularly harmful waste is asbestos using not so long ago in many sectors of economy, including automotive industry. Despite of the ban of production and exploitation of asbestos, waste containing asbestos minerals are still in the environment.
The necessity of the utilization of asbestos waste leads to the development of high-efficiency recycling methods with the application of different technologies. This paper shows the current state of knowledge concerning the asbestos waste with particular reference to the automotive industry. The recycling methods of asbestos used both in laboratory and industrial scale are also presented.
Perancangan Aplikasi Portal Alumni Balai Latihan Kerja (BLK) Kabupaten Kudus Berbasis Web
Authors: Supriyono Supriyono , Arifin Muhammad 
Published: June 2018

BLK Kudus adalah adalah tempat diselenggarakannya proses pelatihan kerja bagi masyarakat Kudus yang mau mengebangkan diri sesuai jenis pelatihan yang diadakan. Disini para peserta pelatihan dilatih agar mampu dan menguasai suatu jenis dan tingkat kompetensi kerja tertentu guna memasuki pasar kerja atau untuk mendirikan usaha mandiri. BLK Kudus i telah menghasilkan ribuan lulusan, tetapi data alumni BLK Kudus masih terarsip secara manual didalam tumpukan berkas. Hal ini menyebabkan informasi tentang alumni sulit didapat dan sulit tidak terekam jejaknya, sehingga menyebabkan BLK sulit dalam mengukur keberhasilan dari pelatihan yang mereka adakan. Penelitian dengan judul “Perancangan Portal Alumni Balai Latihan Kerja (BLK) Kabupaten Kudus” dirancang menggunakan data flow diagram. Perancangan aplikasi ini nantinya diharapkan bisa digunakan untuk membangun portal alumni sehingga mempermudah pihak pengambil keputusan dalam mengukur tingkat keberhasilan pelatihan, mengetahui sebaran alumni, tingkat keterserapan alumni pada dunia kerja, jumlah wira usaha lulusan BLK Kudus. Hal ini dibutuhkan untuk pengambilan keputusan tentang penentuan pelatihan yang akan diadakan.