bluuebunny/crossref_metadata_2025_split huggingface dataset:
EZH2 is essential for fate determination in the mammalian Isthmic area
Authors: Wever Iris , Wagemans Cindy M.R.J. , Smidt Marten P. 
Published: October 2018

AbstractThe polycomb group proteins (PcGs) are a group of epigenetic factors associated with gene silencing. They are found in several families of multiprotein complexes, including Polycomb Repressive Complex (PRC) 2. EZH2, EED and SUZ12 form the core components of the PRC2 complex, which is responsible for the mono, di- and trimethylation of lysine 27 of histone 3 (H3K27Me3), the chromatin mark associated with gene silencing. Loss-of-function studies ofEzh2, the catalytic subunit of PRC2, have shown that PRC2 plays a role in regulating developmental transitions of neuronal progenitor cells; from self-renewal to differentiation and the neurogenic-to-gliogenic fate switch.To further address the function of EZH2 and H3K27me3 during neuronal development we generated a conditional mutant in whichEzh2was removed in the mammalian isthmic (mid-hindbrain) region from E10.5 onward. Loss ofEzh2changed the molecular coding of the anterior ventral hindbrain leading to a fate switch and the appearance of ectopic dopaminergic neurons. The correct specification of the isthmic region is dependent on the signaling factors produced by the Isthmic organizer (IsO), located at the border of the mid- and hindbrain. We propose that the change of cellular fate is a result of the presence ofOtx2in the hindbrain ofEzh2conditional knock-outs and a dysfunctional IsO, as represented by the loss ofFgf8andWnt1.Our work implies that next to controlling developmental transitions, EZH2 mediated gene silencing is important for specification of the isthmic region by influencing IsO functioning and repressingOtx2in the hindbrain.
Corporate performance management: process of organizational-tailored flow chart
Authors: Yilmaz Ayşe Kucuk , Yazgan Ebru 
Published: October 2018

Purpose
Main issue in management and strategy is corporate performance. Managers seek effective and strategic way to improve their performance. Authorization, which includes reputational and strategic indicators, is one of these ways. The applying authorization and using this authorization are decision-making process for managers. These processes have potential to make considerable effect on corporate performance. As a considerable result of this research that need of resource dependency type certified aircraft technicians in Anadolu University are decreased owing to this research and, also the purpose of this study is that technicians have got opportunity to creating own human resource in view of both sustainability, and competition in training field.

Design/methodology/approach
In this study, both specified and organizational-tailored flowchart as the problem solving techniques in decision-making process of maintenance training organization have been developed, compiled after taking the opinions of experts, for the effective implementation of type rating training, following approval, that cover the types of fleet at Anadolu University. This flowchart may guide to the relevant aircraft maintenance training organizations in their type trainings implementation process.

Findings
Human factor is both vital and necessary element to achieve high corporate performance. By following the flow chart, the implementation process is shortened by eliminating the difficulties in complying with the depth and complexity of the required regulation.

Originality/value
The development of the necessary skills and competencies of the workforce is one of the critical points for the creation, preservation and improvement of corporate value. This research has been carried out with the aim of effective utilization of institutional resources, development of personnel and hence corporate value creation. Anadolu University, which is aware of the importance of core competence, is trying to make it one of its strengths institutionally. The Anadolu University Faculty of Aeronautics and Astronautics, as an organization that has completed the necessary steps to become authorized to give type rating training, may guide other aviation organizations using the organization-specified tailored flow chart developed with the help of expert opinion.
Knowledge management, organizational commitment and knowledge-worker performance
Authors: Razzaq Shahid , Shujahat Muhammad , Hussain Saddam , Nawaz Faisal , Wang Minhong , Ali Murad , Tehseen Shehnaz 
Published: October 2018

PurposeKnowledge management in the public sector is relatively an ignored avenue of research and practice that has recently been given attention. Knowledge management initiatives in the public sector are now not limited to the developed countries anymore. The public sectors of various developing countries including Pakistan have developed knowledge management functions to address the problems of low organizational commitment (higher turnover rates) and knowledge-workers’ performance. Consequently, the purpose of this paper is to examine the mediation role of organizational commitment in the relationship between knowledge management practices and knowledge-worker performance.Design/methodology/approachThe data were gathered from 341 knowledge workers of the public sector health department of Punjab Province, Pakistan, where knowledge management unit initiative has been taken. It was then analyzed using the structural equation modeling.FindingsOrganizational commitment partially mediates the relationship between knowledge management practices and knowledge-work performance.Practical implicationsThe public sector policy makers are strongly advised to implement knowledge management units and practices in order to enhance knowledge-work performance as well as organizational commitment.Originality/valueFirst, the model on the mediating role of organizational commitment has never been examined before. Second, the data collection from the public Health Department of Pakistan, a developing country, is relatively rare because the public sector knowledge management studies have mostly been conducted in developed countries. Finally, this study extends the literature on knowledge management in the public sector that is the developing theme in knowledge management discipline while adding knowledge management as a toolkit to enhance knowledge-workers’, organizational commitment and knowledge-work performance.
Wireless technologies and policies for connecting rural areas in emerging countries: a case study in rural Peru
Authors: Espinoza David , Reed David 
Published: October 2018

Purpose
This paper aims to compare the costs of deploying different wireless terrestrial broadband technologies in the Andes and Amazon Regions of Peru. These areas are representatives of different and challenging geographic regions throughout the globe that currently are severely underserved or unserved for vital broadband services necessary to bridge the “Digital Divide”.

Design/methodology/approach
The broadband technologies studied include Wi-Fi, Worldwide Interoperability for Microwave Access (WiMAX), long term evolution (LTE), TVWS and new stratospheric platforms (super-pressure balloons). This study conducts a technical analysis (design and simulation) of wireless broadband networks, and a bottom-up engineering cost analysis to estimate and compare the deployment and operating costs of the networks over a 10-year period. The analysis also identifies potential regulatory barriers to deployment associated with spectrum allocation licenses and overbooking requirements intended to improve quality of service.

Findings
Comparison of the capital and operating expenses of these options over a 10-year period finds that LTE and Wi-Fi can be the lowest cost alternatives, though significantly, stratospheric balloons have the lowest initial costs for the first few years and can factor as a low-cost broadband catalyst early in deployment. Finally, the lowest cost technology broadband roadmap for the 10-year period is presented, which includes using stratospheric balloons (carrying micro-LTE base stations) for the first years and deploying complementary terrestrial LTE networks for the rest of the 10-year period.

Originality/value
This study presents detailed technical and engineering cost analysis results of wireless access network deployments, including advanced wireless technologies and new unmanned aerial systems, to expand broadband services to rural areas in mountainous (Andes Region) and rainforest (Amazon Region) geographies to reduce the digital divide in emerging countries. Results aim to aid governments, regulators, internet service providers (incumbents and competitive) and content providers to assess current alternatives to expand broadband service in these rural areas.
Differential quadrature method for nonlinear fractional partial differential equations
Authors: Saeed Umer , Rehman Mujeeb ur , Din Qamar 
Published: October 2018

Purpose
The purpose of this paper is to propose a method for solving nonlinear fractional partial differential equations on the semi-infinite domain and to get better and more accurate results.

Design/methodology/approach
The authors proposed a method by using the Chebyshev wavelets in conjunction with differential quadrature technique. The operational matrices for the method are derived, constructed and used for the solution of nonlinear fractional partial differential equations.

Findings
The operational matrices contain many zero entries, which lead to the high efficiency of the method and reasonable accuracy is achieved even with less number of grid points. The results are in good agreement with exact solutions and more accurate as compared to Haar wavelet method.

Originality/value
Many engineers can use the presented method for solving their nonlinear fractional models.
Integrating value management into sustainable construction projects in Hong Kong
Authors: Yu Ann Tit Wan , Javed Arshad Ali , Lam Tsun Ip , Shen Geoffrey Qiping , Sun Ming 
Published: October 2018

Purpose
Integrating sustainability into the value management (VM) process can provide a strategic platform for promoting and incorporating sustainable design and development during the lifespans of construction projects. The purpose of this paper is to investigate the strengths, weaknesses, opportunities and threats (SWOT) for integrating sustainability into the VM process in Hong Kong.

Design/methodology/approach
Following an extensive literature review, 45 attributes were identified and grouped into strength, weakness, opportunity and threat elements. A questionnaire survey based on these groupings was supported by semi-structured interviews with public sector clients, value managers and VM facilitators. They shared their experience and views on how to integrate sustainability into the VM exercises.

Findings
The triangulated results of the survey and interviews are presented in this paper. The ranking of the SWOT analysis results indicate that VM does provide opportunities for multidisciplinary professionals and stakeholders to focus on issues relating to society and the environment, which is considered a main strength. The major weakness of integration is the lack of well-trained staff and low levels of VM participant expertise in relation to the sustainable construction issue.

Research limitations/implications
Current practices generally neglect integration of sustainability into the VM process due to cost and time constraints. There are ample strengths and opportunities recommended by this study for integrating sustainability into the VM process which are beneficial for the clients and contractors for achieving value for money and meeting sustainability targets.

Practical implications
There are immense opportunities for integrating sustainability into the VM process, including encouragement of the reduction, reuse and recycling of construction and demolition waste. However, threats presented by integration include the additional time and costs required for achieving sustainability targets.

Originality/value
Findings and recommendations provided in this paper should be helpful to decision makers including clients and VM facilitators for the successful integration of the sustainability concept into the VM process.
Stakeholder complexity in large scale green building projects
Authors: Mok Ka Yan , Shen Geoffrey Qiping , Yang Rebecca 
Published: October 2018

Purpose
In response to the world’s rising awareness on sustainability, industry players and policymakers are devoting great efforts to bolster green building developments. Every green building project (GBP) involves numerous stakeholders and potentially incompatible concerns. Despite the associated environmental, economic and social benefits, GBP developments have often confronted managerial barriers which are actually emerged from stakeholders – the actual key determinants of a project. Holistically analyzing the complexity of stakeholders in GBPs is, therefore, crucial to improving GBP management and achieving greater sustainability for all involved. The purpose of this paper is to analyze stakeholder complexity in large GBPs using a holistic framework which integrates both empirical and rationalistic analytical perspectives.

Design/methodology/approach
The complexity of stakeholders in GBPs can be considered from three aspects – identifying stakeholders, assessing stakeholder interactions and analyzing stakeholder concerns. The proposed stakeholder analysis framework uses both empirical methods (e.g. interviews and surveys) and rationalistic methods (e.g. chain referral sampling and social network analysis) to analyze GBP stakeholder complexity. Case study of a lab-enabled commercial GBP in Hong Kong was undertaken to illustrate the framework.

Findings
The framework enables a holistic, objective and effective stakeholder analysis; leading GBP leaders toward a complete understanding of project stakeholder complexity. The case study findings bring managerial insights to GBP leaders on the general SNA-related stakeholder dynamics and the important stakeholder concerns, of large Hong Kong GBPs. The findings diagnose general connectivity structures of GBP stakeholders, identify influential and peripheral actors in GBP information exchange, and suggest clues to improve their dynamics. In addition, ten key stakeholder concerns were identified, including comprehensive governmental standards and procedures, clear sustainability goals at the outset, effective stakeholder engagement, adequate design flexibility, and a “can-do” attitude of contractors and consultants – which are all vital for successful GBP development. The underlying reasons of these concerns and recommendations to addressing them were also discussed.

Originality/value
Many existing GBP stakeholder studies appear to use a single analytical perspective to assess project stakeholder complexity, but this may not gain a full understanding. The holistic stakeholder analysis framework used herein combines empiricism and rationalism. It helps to bring GBP leaders and implementers toward a more informed project decision making, a more thorough understanding of stakeholder complexity, as well as a more effective engagement of stakeholders.
A bibliometric review on innovation systems and ecosystems: a research agenda
Authors: Suominen Arho , Seppänen Marko , Dedehayir Ozgur 
Published: October 2018

Purpose
The ecosystem perspective on innovation and business has emerged as the secret sauce of innovative organizations. While its theoretical foundations are premised on innovation system literature, the broad adoption of the ecosystem concept has resulted in conceptual ambiguity. The purpose of this paper is to tackle the ambiguous use of innovation ecosystem terminology and structure a conceptual frame for the field, identifying definitions of an innovation ecosystem and how the concept has been established in previous literature.

Design/methodology/approach
This paper examines the ambiguous use of terminology by reviewing the literature with bibliometric coupling and co-citation analysis by which thematic differences in ecosystem literature were identified. The study gathered the scientific publications from Thomson Reuters Web of Sciences Core Collection (n=4,681) from 1990 to 2015.

Findings
Six major bibliometrically coupled clusters were identified, of which the three largest clusters are innovation system studies, regional innovation studies and technological innovation studies. In addition, further analysis shows an emerging cluster that is focused on ecosystems, having its roots in eight seminal papers. This ecosystem research cluster includes seven sub-clusters, such as innovation ecosystem studies, business ecosystem studies and studies focusing on ecosystem development.

Research limitations/implications
The authors’ approach highlights how a lot of recent ecosystem studies actually belong to previous, well-developed research streams. However, there is also a separate, emergent research stream that includes the innovation and ecosystem studies. As a research implication, the paper concludes by suggesting the research agenda for further studies.

Originality/value
Even though literature on innovation systems and ecosystems is extensive literature, no studies have captured the emergence of the ecosystems approach and its relation with the systems of innovation literature.
Benefits and barriers in uptake of mobile apps in New Zealand construction industry
Authors: Liu Tong , Mathrani Anuradha , Mbachu Jasper 
Published: October 2018

Purpose
Mobile apps offer construction workers a quick, affordable and user-friendly platform for meeting their information, communication and computing needs, with nearly 13,000 construction apps currently available in the market. This study aims to report construction managers’ perspectives on the uptake of mobile apps in the New Zealand construction industry.

Design/methodology/approach
Exploratory research methods were used in two stages. First stage involved interviews with 14 construction managers who were registered with the New Zealand Registered Master Builders Association, followed by an online questionnaire in the second stage. The link of online questionnaire was sent to all members of participating professional organisations by their administrators. In total, 228 responses were received, of which 60 per cent participants completed the entire questionnaire.

Findings
Results show an overall positive attitude towards the use of apps. Perceptions of top management personnel differed slightly from those of middle managers; the former expressed interest in apps usage at strategic level such as improving long-term client relationship management and satisfaction; while the latter were more interested in the apps use at operational and tactical levels such as task- or project-level productivity improvement.

Research limitations/implications
Though bias has been minimised by giving equal opportunity to each member of trade and professional organisations to participate in this survey, of the 228 responses received, only 60 per cent participants completed the entire questionnaire. This is below the minimum requirement for a holistic representation of views. As a result, the findings might not be generalised beyond the study’s scope.

Originality/value
The study provides new insights on the uptake of smartphone apps in New Zealand’s construction sector from the perspective of construction managers who make strategic decisions. The findings have implications for policy formulation and implementation in regards to the use of mobile apps for productivity improvement in the sector. Mobile apps developers could also gain understanding on functional needs and preferences of the construction workforce, which will help in development of more relevant apps.
On Darcy-Forchheimer squeezed flow of carbon nanotubes between two parallel disks
Authors: Hayat Tasawar , Ayub Tayyaba , Muhammad Taseer , Alsaedi Ahmed , Mustafa M. 
Published: October 2018

PurposeThe purpose of this paper is to construct mathematical model for squeezed flow of carbon-water nanofluid between parallel disks considering Darcy–Forchheimer porous medium. Thermal conductivity of carbon nanotubes is estimated through the well-known Xue model. Such research work is not carried out in the past even in the absence of Darcy–Forchheimer porous space. Forchheimer equation is preferred here to account for both low and high velocity inertial effects. Researchers also found that dispersion of carbon nanotubes in water elevates the thermal conductivity of resulting nanofluid by 100 per cent.Design/methodology/approachHomotopy analysis method (HAM) is used for the convergent series solutions of the governing system.FindingsNusselt number at the lower disk increases when squeezing parameter Sq enlarges. This illustrates that heat transfer rate at the lower wall can be enhanced by increasing the squeezing velocity of the lower disk. The results demonstrate a decreasing trend in temperature profile for increasing volume fraction of carbon nanotubes. Moreover, improvement in heat transfer rate because of existence of carbon nanotubes is also apparent. A significant enhancement in temperature profile is depicted when inertial permeability coefficient is enhanced. Skin friction coefficients at the lower and upper disks are higher for MWCNTs in comparison to the SWCNTs.Originality/valueTo the best of author’s knowledge, no such consideration has been given in the literature yet.
“Do I fit in?” Signals on corporate websites
Authors: Stockdale Emma , William Laura Catherine , Whiley Lilith 
Published: October 2018

Purpose
Prospective job applicants tend to use signals that are presented on corporate websites to form perceptions about the organizations. Specifically, they decide whether they would “fit in.” The purpose of this paper is to examine the explicit and implicit signals presented by Financial Times Stock Exchange 250 Index (FTSE250) companies on their corporate websites.

Design/methodology/approach
A content analysis was carried out on FTSE250 corporate websites.

Findings
While many corporate websites do include general references to diversity, they do not engage with different protected characteristics on an equal basis. Furthermore, corporate websites often espouse the legal and business cases rationale for engaging with diversity.

Research limitations/implications
The authors were restricted by the information presented on corporate websites. Further research could use a multi-modal approach and include analysis of images.

Practical implications
Companies need to consider their overall rationale for engaging with diversity. Fostering a culture of inclusion where diversity is celebrated will allow companies to showcase their genuine commitment to diversity on their websites and avoid sending disingenuous signals to minority groups.

Social implications
Increasing the perceived “fit” of minority groups in an organizational culture will foster inclusion and diversity and support minority group engagement.

Originality/value
This research examines diversity signals and relates these to job applicants’ perceptions.