bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative skeletal muscle index vs the controlling nutritional status score: Which is a better objective predictor of long‐term survival for gastric cancer patients after radical gastrectomy?
Authors: Zheng Zhi‐Fang , Lu Jun , Xie Jian‐Wei , Wang Jia‐Bin , Lin Jian‐Xian , Chen Qi‐Yue , Cao Long‐Long , Lin Mi , Tu Ru‐Hong , Zheng Chao‐Hui , Huang Chang‐Ming , Li Ping 
Published: June 2018

AbstractSkeletal muscle index (SMI) and the controlling nutritional status (CONUT) score are useful for evaluating nutritional status, which is closely associated with cancer prognosis. This study compared the prognostic value of these indicators in patients with gastric cancer (GC) after radical gastrectomy (RG). We retrospectively enrolled 532 patients between 2010 and 2011. SMI was measured via CT images to determine low SMI. The CONUT score was calculated based on serum albumin, total lymphocyte count, and cholesterol. Patients were grouped according to SMI and the CONUT score based on previous research. Spearman's correlation coefficient, the Kaplan‐Meier method, and Cox regression were used. There was no significant correlation between SMI and the CONUT score. Five‐year overall survival (OS) and recurrence‐free survival (RFS) in patients with low SMI were significantly worse than those in patients with high SMI (P < .001). The normal nutrition group had better OS and RFS than did the light and moderate or severe malnutrition groups (P < .05), but the OS and RFS were not significantly different between the light and moderate or severe malnutrition groups (P = .726). Univariate analysis showed that SMI and the CONUT score were associated with OS and RFS, but only SMI remained prognostic in multivariate analysis. Preoperative SMI based on CT images is a more objective predictor than the CONUT score of long‐term survival in GC after RG, but this finding must be confirmed by prospective trials.
In Vivo Incorporation of Azide Groups into DNA by Using Membrane‐Permeable Nucleotide Triesters
Authors: Tera Masayuki , Glasauer Stella M. K. , Luedtke Nathan W. 
Published: June 2018

AbstractMetabolic incorporation of bioorthogonal functional groups into cellular nucleic acids can be impeded by insufficient phosphorylation of nucleosides. Previous studies found that 5azidomethyl‐2′‐deoxyuridine (AmdU) was incorporated into the DNA of HeLa cells expressing a low‐fidelity thymidine kinase, but not by wild‐type HeLa cells. Here we report that membrane‐permeable phosphotriester derivatives of AmdU can exhibit enhanced incorporation into the DNA of wild‐type cells and animals. AmdU monophosphate derivatives bearing either 5′‐bispivaloyloxymethyl (POM), 5′‐bis‐(4‐acetoxybenzyl) (AB), or “Protide” protective groups were used to mask the phosphate group of AmdU prior to its entry into cells. The POM derivative “POM‐AmdU” exhibited better chemical stability, greater metabolic incorporation efficiency, and lower toxicity than “AB‐AmdU”. Remarkably, the addition of POM‐AmdU to the water of zebrafish larvae enabled the biosynthesis of azide‐modified DNA throughout the body.
Quality prediction via semisupervised Bayesian regression with application to propylene polymerization
Authors: Sun Yuanmeng , Liu Xinggao , Zhang Zeyin 
Published: June 2018

AbstractStatistical learning techniques are widely used for quality prediction in polymerization processes during the last decades. However, compared to operation variables, quality variables of polypropylene process are usually difficult to acquire resulting from the absence of measuring units. A semisupervised Bayesian regression method is therefore presented to improve the prediction accuracy by sufficient usage of unlabeled sampling data for melt index prediction in polypropylene processes. The developed model consists of Bayesian inference to predict quality variables and neighborhood kernel density estimation for finding relationships between unlabeled data and labeled samples, which takes advantages of a probability framework with iterative maximum likelihood techniques for parameter estimation and a sparse constraint for avoiding overfitting. The quality prediction regression method is compared with published models by applying to a real dataset of industrial propylene polymerization. The experiment results demonstrate the effectiveness of the proposed semisupervised Bayesian method.
Developing a ridge estimator for the gamma regression model
Authors: Algamal Zakariya Yahya 
Published: June 2018

AbstractThe ridge regression model has been consistently demonstrated to be an attractive shrinkage method to reduce the effects of multicollinearity. The gamma regression model is a very popular model in the application when the response variable is positively skewed. However, it is known that multicollinearity negatively affects the variance of maximum likelihood estimator of the gamma regression coefficients. To address this problem, a gamma ridge regression model has been proposed. In this study, a new estimator is developed by proposing a modification of Jackknife estimator with gamma ridge regression model. Our Monte Carlo simulation results and the real data application suggest that the proposed estimator can bring significant improvement relative to other competitor estimators, in absolute bias and mean squared error.
Injectable Oxygen: Interfacing Materials Chemistry with Resuscitative Science
Authors: Peng Yifeng , Kheir John N. , Polizzotti Brian D. 
Published: June 2018

AbstractIntravascular oxygen delivery holds great potential to treat numerous hypoxic conditions and emergencies, including pulmonary disorders, hypoxic tumors, hemorrhagic shock, stroke, cardiac arrest and so on. Tremendous effort has been made in the past to find material solutions for the development of intravenous oxygen carriers and have ranged from blood substitutes to microbubbles with limited success. This paper highlights previous and recent progress in perfluorocarbon‐emulsions and microbubbles as intravenous gas carriers, including concerns over their long‐term stability, in vivo safety profiles, and oxygen transport efficacy. Their use as potential resuscitative therapeutics for treating various types of cardiac arrest is also discussed.
Expression and Purification of Recombinant Proteins Using the Baculovirus System
Authors: Murphy Cheryl Isaac , Piwnica‐Worms Helen , Grünwald Stefan , Romanow William G. , Francis Nicole , Fan Hua‐Ying , Marr Sharon 
Published: June 2018

AbstractThis article describes how to analyze protein expression in cells infected with recombinant baculovirus on a small scale for optimizing protein production, how to maximize and scale up recombinant protein production, and how to purify recombinant proteins. © 2018 by John Wiley & Sons, Inc.
AHNS Series: Do you know your guidelines? Principles for treatment of cancer of the paranasal sinuses: A review of the National Comprehensive Cancer Network guidelines
Authors: Byrd J. Kenneth , Clair Jon Mallen‐St. , El‐Sayed Ivan 
Published: June 2018

AbstractThis article is a continuation of the “Do You Know Your Guidelines” series. This was launched as an initiative of the American Head and Neck Society to increase the awareness of current best practices pertaining to head and neck cancer. The National Comprehensive Cancer Network (NCCN) guidelines for managing cancer of the paranasal sinuses are reviewed in a systematic fashion. These guidelines outline the workup, treatment, and surveillance of patients with cancer of the maxillary and ethmoid sinuses.
CAREGIVER SENSITIVITY AND CONSISTENCY AND CHILDREN'S PRIOR FAMILY EXPERIENCE AS CONTEXTS FOR EARLY DEVELOPMENT WITHIN INSTITUTIONS
Authors: Hawk Brandi N. , Mccall Robert B. , Groark Christina J. , Muhamedrahimov Rifkat J. , Palmov Oleg I. , Nikiforova Natalia V. 
Published: June 2018

ABSTRACTThe current study addressed whether two institution‐wide interventions in St. Petersburg, Russian Federation, that increased caregiver sensitivity (Training Only: TO) or both caregiver sensitivity and consistency (Training plus Structural Changes: T+SC) promoted better socioemotional and cognitive development than did a No Intervention (NoI) institution during the first year of life for children who were placed soon after birth. It also assessed whether having spent less than 9 versus 9 to 36 months with a family prior to institutionalization was related to children's subsequent socioemotional and cognitive development within these three institutions. The Battelle Developmental Inventory (J. Newborg, J.R. Stock, L. Wnek, J. Guidubaldi, & J. Svinicki, 1988) was used to assess the socioemotional and cognitive functioning of children in NoI (n = 95), TO (n = 104), and T+SC (n = 86) at two to three time points during their first 6 to 12 months of residency. Results suggest that improving caregiver sensitivity can improve the cognitive development of infants in the first year of institutionalization whereas improving caregiver consistency in addition to sensitivity is more beneficial for socioemotional development than is sensitivity alone. Similarly, for children in T+SC, longer time with a family prior to institutionalization (consistent caregiver, unknown sensitivity) was associated with better socioemotional, but not cognitive, baseline scores and more rapid cognitive than socioemotional development during institutionalization. These results suggest caregiver sensitivity is more highly related to cognitive development whereas caregiver consistency is more related to socioemotional development in the first years of life.
OBSERVATION AND COMPARISON OF MEALTIME BEHAVIORS IN A SAMPLE OF CHILDREN WITH AVOIDANT/RESTRICTIVE FOOD INTAKE DISORDERS AND A CONTROL SAMPLE OF CHILDREN WITH TYPICAL DEVELOPMENT
Authors: Aldridge Victoria K. , Dovey Terence M. , El Hawi Nicole , Martiniuc Antonie , Martin Clarissa I. , Meyer Caroline 
Published: June 2018

ABSTRACTDespite widespread use of behavioral observations to evaluate child feeding behaviors in research and clinical practice, few studies have comprehensively characterized mealtimes or identified features that differentiate children with and without disordered feeding; these were the aims of the current study. Mealtime observations were conducted for 18 children with avoidant restrictive food intake disorder (ARFID) and 21 typically developing children. Observations were coded inductively, and associations between disorder and observed mealtime actions were examined. Most behaviors were observed across both clinical and nonclinical mealtimes, and many did not differ in frequency between children with and without ARFID. However, significant group differences were observed in the frequencies of behaviors relating to food intake, visual and physical engagement with feeding, and movement during mealtimes. The comparability of behaviors across clinical and nonclinical groups suggests that eating behaviors exist on a continuum from “normal” to “abnormal,” with group differences relating to frequency rather than type of behavior. The behavioral differences observed in this study suggest that identification of children with ARFID should focus on child engagement with food and restlessness during mealtimes. Reliance on emotional and escape‐maintained behaviors will lead to underrecognition of families in need of clinical support.
Mir‐1287 suppresses the proliferation, invasion, and migration in hepatocellular carcinoma by targeting PIK3R3
Authors: Lu Junhao , Tang Licheng , Xu Yuqiang , Ge Kuikui , Huang Jinjiang , Gu Meigang , Zhong Jiang , Huang Qingshan 
Published: June 2018

AbstractMature microRNAs (miRNAs) are a class of small noncoding RNA molecules involved in regulation of post‐translational gene expression. Although aberrant levels of miRNAs have been found in various tumor tissues, their importance in tumor development and the molecular basis of their regulatory role remain unclear. Our bioinformatic analysis on The Cancer Genome Atlas database and microarray‐based comparison of miRNA in different cell lines revealed that the level of mir‐1287 is suppressed in hepatocellular carcinoma (HCC) cells. When upregulated, mir‐1287 can reduce the tumorigenesis phenotypes of HCC cells in several in vitro models. We further found that mir‐1287 directly targets messenger RNA encoding PIK3R3, which is a tumor‐promoting factor acting in several pathways linked to tumorigenesis. Our study suggests that aberrant suppression of mir‐1287 is potentially responsible for the development of HCC, and miRNA‐based strategies may be developed for efficient detection and treatment of HCC.
NLRP3 inﬂammasome mediates chronic intermittent hypoxia‐induced renal injury implication of the microRNA‐155/FOXO3a signaling pathway
Authors: Wu Xu , Chang Su Chi , Jin Jifu , Gu Wenyu , Li Shanqun 
Published: June 2018

Chronic intermittent hypoxia (CIH), as the foremost pathophysiological change of obstructive sleep apnea (OSA), contributes to continued deterioration in renal function. Nucleotide‐binding domain like receptor protein 3 (NLRP3) inflammasome is a multiprotein complex that triggers innate immune responses to infection and cell stress through activation of caspase‐1 and maturation of inflammatory pro‐interleukin‐1β cytokine. Emerging evidence indicates that inhibition of the NLRP3 inflammasome ameliorates renal injury. Nevertheless, it is uncertain whether NLRP3 inflammasome participates in CIH‐induced renal injury. The molecular mechanisms modulating NLRP3 inﬂammasome activation remain to be elucidated. Compared with wild‐type mice, NLRP3 knockout mice dramatically protected them from kidney injury, as indicated by the restoration of creatinine levels, lessened histopathological alterations, and the suppression of macrophages inﬁltration stained with F4/80. NLRP3 deﬁciency notably reversed CIH‐induced oxidative stress (malondialdehyde and superoxide dismutase), concomitantly with the abrogated apoptosis‐related proteins and proinflammatory signaling pathway. Consistently, NLRP3‐deﬁcient tubular cells remarkably inhibited reactive oxygen species generation and NLRP3 inﬂammasome activation. Furthermore, our study revealed that microRNA‐155 (miR‐155) was augmented in the renal tissue and HK‐2 cells exposed to CIH. In addition, we investigated the role of miR‐155 in the regulation of NLRP3 inﬂammasome. Inhibition of miR‐155 suppressed the CIH‐induced NLRP3 inﬂammasome activation in renal tubular cells, whereas overexpression of miR‐155 promoted oxidation and enhanced NLRP3 pathway. Collectively, we demonstrated that miR‐155 might be a positive‐regulator of NLRP3 pathway by inhibiting the targeted FOXO3a gene. These results established a link between the miR‐155/FOXO3a pathway and the NLRP3 inﬂammasome, suggesting pharmacological blockage of NLRP3 as a potential therapeutic strategy for OSA‐associated chronic kidney disease.
Effects of experimental light at night on extra‐pair paternity in a songbird
Authors: de Jong Maaike , Lamers Koosje P. , Eugster Mark , Ouyang Jenny Q. , Da Silva Arnaud , Mateman A. Christa , van Grunsven Roy H.A. , Visser Marcel E. , Spoelstra Kamiel 
Published: June 2018

AbstractLight pollution is increasing worldwide and significantly affects animal behavior. In birds, these effects include advancement of morning activity and onset of dawn song, which may affect extra‐pair paternity. Advanced dawn song of males may stimulate females to engage in extra‐pair copulations, and the earlier activity onset may affect the males’ mate guarding behavior. Earlier work showed an effect of light at night on extra‐pair behavior, but this was in an area with other anthropogenic disturbances. Here, we present a two‐year experimental study on effects of light at night on extra‐pair paternity of great tits (Parus major). Previously dark natural areas were illuminated with white, red, and green LED lamps and compared to a dark control. In 2014, the proportion of extra‐pair young in broods increased with distance to the red and white lamps (i.e., at lower light intensities), but decreased with distance to the poles in the dark control. In 2013, we found no effects on the proportion of extra‐pair young. The total number of offspring sired by a male was unaffected by artificial light at night in both years, suggesting that potential changes in female fidelity in pairs breeding close to white and red light did not translate into fitness benefits for the males of these pairs. Artificial light at night might disrupt the natural patterns of extra‐pair paternity, possibly negates potential benefits of extra‐pair copulations and thus could alter sexual selection processes in wild birds.
Facile Synthesis of Pyrazolo[3,4‐c]pyrazoles Bearing Coumarine Ring as Anticancer Agents
Authors: Gomha Sobhi M. , Abdel‐aziz Hassan M. , El‐Reedy Ahmed A. M. 
Published: June 2018

In the present study, 2‐(2‐oxo‐2H‐chromene‐3‐carbonyl)‐5‐phenyl‐2,4‐dihydro‐3H‐pyrazol‐3‐one was prepared and reacted with various hydrazonoyl halides to give a series of 2‐(2‐oxo‐2H‐chromene‐3‐carbonyl)‐5‐phenyl‐4‐((2‐phenylhydrazono)methyl)‐2,4‐dihydro‐3H‐pyrazol‐3‐one in good yield. Cyclization of the latter hydrazone with POCl3 yielded the respective 3‐(3‐phenyl‐ 4,6‐disubstituted‐1,6‐dihydropyrazolo[3,4‐c]pyrazole‐1‐carbonyl)‐2H‐chromen‐2‐ones. The structures of the newly synthesized compounds were established on the basis of spectroscopic evidences and their alternative syntheses. The newly synthesized compounds were evaluated for their antitumor activities against hepatocellular carcinoma (HepG2) cell line and the results revealed promising activities of compounds 4e, 4c, and 4d with IC50 equal 0.92 ± 0.22, 1.43 ± 0.19, and 2.17 ± 0.21 μM, respectively.
Raman microscopy as a tool to discriminate mineral phases of volcanic origin and contaminations on red and yellow ochre raw pigments from Pompeii
Authors: Marcaida Iker , Maguregui Maite , Morillas Héctor , Veneranda Marco , Prieto‐Taboada Nagore , Fdez‐Ortiz de Vallejuelo Silvia , Madariaga Juan Manuel 
Published: June 2018

AbstractRaman microscopy is a molecular technique that is able to detect compounds that are present in the samples at minor/trace levels thanks to the precise focusing on particles of interest. The detection will also depend on the Raman scattering of the measured compound. Moreover, due to the nondestructive character of the measurements, this technique is one of the most used when samples under study belong to the arts and archaeological fields. Among the different archaeological sites in the world, Pompeii is one of the most important ancient cities. In this work, Raman microscopy—supported by X‐ray diffraction—has been used to detect traces of mineralogical phases of volcanic origin and contaminations in red and yellow ochre pigments. These samples were buried for thousands of years and recovered from the archaeological site of Pompeii in their original bowls. On the one hand, regarding the characteristic mineral phases of volcanic origin, the obtained results showed the presence of langite [Cu4 (SO4)(OH)6·2H2O], jarosite [KFe3 (SO4)2(OH)6], atacamite [Cu2Cl (OH)3], and anatase (β‐TiO2), a polymorph of titanium oxide found in igneous rocks. On the other hand, contamination compounds such as Egyptian or Pompeian blue (CaCuSi4O10) and huntite [Mg3Ca (CO3)4] were also identified. Some of the compounds identified by micro‐Raman spectroscopy could not be detected using X‐Ray diffraction and vice versa. Therefore, it was corroborated the necessity of using more than one unique technique in order to obtain a complete information about the molecular composition of the ochre pigments under study.
Effects of three different stunning/slaughtering methods on physical, chemical, and sensory changes in rainbow trout (Oncorhynchus mykiss)
Authors: Concollato Anna , Dalle Zotte Antonella , Vargas Sheyla C , Cullere Marco , Secci Giulia , Parisi Giuliana 
Published: June 2018

AbstractBACKGROUNDElectrical stunning (E) and asphyxia in the air (A) are two common stunning/killing methods for fish. However, they can stress the fish and affect flesh quality, so an alternative should be found. The present study aimed to evaluate the effects of carbon monoxide asphyxia (CO) compared to E and A on the evolution of post rigor mortis changes in rainbow trout (Oncorhynchus mykiss) fillets related to chemical, textural, and sensorial properties during storage time.RESULTSFish fillets from the E group showed a higher pH (P < 0.05) than the A ones, both at time of rigor resolution (TRR0) and from TRR4 until TRR7 (7 days after rigor resolution, which corresponded to 10 days post mortem), with the CO group being always intermediate. The CO treatment ensured that the fillets showed the lowest yellowness index (b*), even if only at TRR2 and TRR5. Lipid oxidation and texture profile analyses were unaffected. Sensory analysis revealed that the CO fillets had the lowest odor intensity and the highest juiciness scores (P < 0.05). The sensory descriptors resulted the most discriminant variables of the fillets obtained from the differently stunned animals, as resulted by the canonical discriminant analysis.CONCLUSIONThe carbon monoxide stunning/slaughtering method could be applied to rainbow trout without detrimental effects on physical, chemical, or sensory characteristics of the fish flesh. © 2018 Society of Chemical Industry
Discrete fracture analysis using locally refined T‐splines
Authors: Chen L. , Verhoosel C. V. , de Borst R. 
Published: June 2018

SummaryLocally refined T‐splines are used to model discrete crack propagation without a predefined interface. The crack is introduced by meshline insertions in the locally refined T‐mesh, which yields discontinuous basis functions. To implement the method in existing finite element programs, Bézier extraction is used. A detailed description is given as to how the crack path is inserted and how the domain is reparameterized after insertion. The versatility and accuracy of the approach to model discrete crack propagation without the crack path being predefined is demonstrated by two examples, namely, an L‐shaped beam and a single‐edge notched beam. When the crack approaches the physical boundaries, limitations to reparameterization arise, as will be discussed at the hand of a double‐edge notched specimen.
Recycling of solution spaces in multipreconditioned FETI methods applied to structural dynamics
Authors: Leistner Michael C. , Gosselet Pierre , Rixen Daniel J. 
Published: June 2018

SummaryThis article presents a new method to recycle the solution space of an adaptive multipreconditioned finite element tearing and interconnecting algorithm in the case where the same operator is solved for multiple right‐hand sides like in linear structural dynamics. It accelerates the computation from the second time step on by applying a coarse space that is generated from Ritz approximations of local eigenproblems, using the solution space of the first time step. These eigenproblems are known to provide very efficient coarse spaces but must usually be solved a priori at high computational cost. Their Ritz approximations are much smaller and less expensive to solve. Recycling methods based on Ritz approximations of global eigenproblems have been published for classical finite element tearing and interconnecting algorithms, but their efficient application to multipreconditioned variants is not possible. This article also presents the application of a simpler recycling procedure, which reuses plain solution spaces, to adaptive multipreconditioned finite element tearing and interconnecting. Numerical results of the application of the presented methods to four test cases are shown. The new Ritz approximation method leads to coarse spaces, which turn out to be as efficient as those obtained from solving the unreduced eigenproblems. It is the most efficient recycling method currently available for multipreconditioned dual domain decomposition techniques.