bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histone Chaperone Paralogs Have Redundant, Cooperative, and Divergent Functions in Yeast
Authors: Savic Neda , Shortill Shawn P , Bilenky Misha , Dobbs Joseph M , Dilworth David , Hirst Martin , Nelson Christopher J 
Published: October 2019

Abstract
Gene duplications increase organismal robustness by providing freedom for gene divergence or by increasing gene dosage. The yeast histone chaperones Fpr3 and Fpr4 are paralogs that can assemble nucleosomes in vitro; however, the genomic locations they target and their functional relationship is poorly understood. We refined the yeast synthetic genetic array approach to enable the functional dissection of gene paralogs. Applying this method to Fpr3 and Fpr4 uncovered redundant, cooperative, and divergent functions. While Fpr3 is uniquely involved in chromosome segregation, Fpr3 and Fpr4 cooperate to regulate genes involved in polyphosphate metabolism and ribosome biogenesis. We find that the TRAMP5 RNA exosome is critical for fitness in Δfpr3Δfpr4 yeast and leverage this information to identify an important role for Fpr4 at the 5′ ends of protein coding genes. Additionally, Fpr4 and TRAMP5 negatively regulate RNAs from the nontranscribed spacers of ribosomal DNA. Yeast lacking Fpr3 and Fpr4 exhibit a genome instability phenotype at the ribosomal DNA, which implies that these histone chaperones regulate chromatin structure and DNA access at this location. Taken together. we provide genetic and transcriptomic evidence that Fpr3 and Fpr4 operate separately, cooperatively, and redundantly to regulate a variety of chromatin environments.
Privatautonomie im Bereich des Commercial Banking
Authors: Piekenbrock Andreas , Rodi Daniel 
Published: October 2019

Zusammenfassung
Der Beitrag schließt die in ZBB 2019, 245 begonnene zweiteilige Abhandlung über den Zustand der Privatautonomie im Bereich des Commercial Banking ab. Er befasst sich eingehend mit der Inhaltsfreiheit, namentlich deren Beschränkung durch den Kontrahierungszwang nach dem Zahlungskontengesetz (§§ 31 ff. ZKG), durch sonstiges zwingendes Recht sowie insbesondere durch die seitens des XI. Zivilsenats des BGH sehr streng gehandhabte AGB-Kontrolle. Hierbei ergibt sich u. a., dass ein Verstoß gegen den Angemessenheitsvorbehalt in § 41 Abs. 2 ZKG zur Unentgeltlichkeit des Kontos führt und eine geltungserhaltende Reduktion auf das angemessene Entgelt de lege lata nicht in Betracht kommt. Ferner zeigt sich, dass die Vereinbarung eines Entgelts für eine Sonderleistung lediglich in der Theorie einen gangbaren Weg zur Vermeidung der AGB-Kontrolle darstellt, in der Praxis hingegen durch die exzessive kundenfeindlichste Auslegung des XI. Zivilsenats vor nahezu unüberwindliche Hürden gestellt wird. Bei strikter Anwendung der vom XI. Zivilsenat aufgestellten Grundsätze wäre zudem denkbar, dass die Vereinbarung negativer Zinsen in Neuverträgen – unzutreffenderweise – für unzulässig erklärt wird. Das Gesamtfazit zum Zustand der Privatautonomie im Bereich des Commercial Banking erweist sich als ernüchternd.
Der Abfindungsanspruch beim Rückzug aus dem regulierten Markt – eine empirische Evaluation der gesetzlichen Neuregelung
Authors: Berninger Marc , Schiereck Dirk , van de Vathorst Dominik 
Published: October 2019

Zusammenfassung
Der Beitrag untersucht im Nachgang an die Neuregelung des regulären Delistings in § 39 BörsG im Jahr 2015 die Aktienkursreaktionen bei 32 deutschen Unternehmen, die nach Inkrafttreten dieser Vorschriften einen Rückzug vom regulierten Markt, vom Freiverkehr oder einen Segmentwechsel angekündigt haben. Durch das Gesetz zur Umsetzung der Transparenzrichtlinie-Änderungsrichtlinie wurden Ende des Jahres 2015 neue rechtliche Rahmenbedingungen für den freiwilligen Börsenrückzug geschaffen, deren Auswirkungen noch nicht auf empirischer Grundlage überprüft wurden.
So stellt sich einerseits die Frage, ob die anlegerschützenden Maßnahmen in Form eines verpflichtenden Abfindungsangebots ihren Zweck tatsächlich erfüllen und einen systematischen Kursverfall, wie er unter der Frosta-Rechtslage beobachtet wurde, verhindern. Anderseits soll im Hinblick auf die aktuelle Diskussion über den Geltungsbereich der neuen Vorschriften überprüft werden, inwiefern Anleger, deren UnterUnternehmen nehmen lediglich einen Segmentwechsel in den Freiverkehr vollzieht, schützenswert sind. Es wird mittels einer Ereignisstudie gezeigt, dass Kleinanleger durch die neuen Schutzmechanismen vor einem systematischen Kursverfall bewahrt werden. Ferner wird eine erste Indikation präsentiert, dass Kleinanleger und Minderheitsaktionäre durch die neuen Vorschriften bei einem Wechsel vom regulierten Markt in den Freiverkehr möglicherweise sogar finanziell bevorteilt werden. Eine anschließende Analyse der Aktienliquidität zeigt, dass Aktien, deren Emittent vom regulierten Markt in den Freiverkehr wechselt, entgegen der vorherrschenden Meinung, nicht zwangsläufig an Liquidität einbüßen. Möglicherweise bedürfen die novellierten Rahmenbedingungen für den Börsenrückzug und insbesondere die Abfindungspflicht beim Segmentwechsel somit noch einiger regulatorischer Adjustierungen.
Persepsi Etika Penggelapan Pajak: Pengaruh Langsung dan Tidak Langsung
Authors: Sofha Dewi , Machmuddah Zaky 
Published: October 2019

Tax evasion could be seen as ethical deed or not depends on several factors. The goal of this research is to examine the influence of gender, religiosity, and love of money towards tax evasion ethical perspective. The population of this research is undergraduate (S1) accounting students from private universities in Semarang. The sample used in this research covers final semester the undergraduate (S1) accounting students from University of Dian Nuswantoro, University of Soegijapranata Catholic, University of Sultan Agung Islamic, University of Muhammadiyah Semarang, University of Stikubank, University of Wahid Hasyim and University of AKI. The sampling technique used in this research is accidental sampling. As much as 100 questionnaires have been spread to the chosen respondents and all of them are declared proper to use. The analysis result is gender and religiosity do have impact on tax evasion ethical perspective while love of money does not. This research’s result also shows that religiosity and love of money do not mediate the relationship between gender and tax evasion ethicalperspective.
Mendidik Anak Shaleh: Telaah Kisah Nabi Ibrahim A.S. Dan Ismail A.S.
Authors: Rahmah Miftahur 
Published: October 2019

Nabi Ibrahim adalah sosok orang tua yang berhasil mendidik anaknya Ismail.Dalam al-Quran ditemukan beberapa komponen pendidikan Islam yang diterapkan oleh nabi Ibrahim terhadap anaknya, Ismail.Pertama, tujuan pendidikan nabi Ibrahim a.s adalah menjadikan anak bertauhid dan mewujudkan anak.yang shaleh. Kedua, sifat nabi Ibrahim sebagai seorang pendidik, yaitu shiddiq, waffa,halim, munib, muhsin, ummah, qanitanlillah, hanif dan Khalil. Ketiga, sifat nabi Ismail sebagai peserta didik, yaitu halim, sabar, taat dan penyayang.Keempat, materi pendidikan nabi Ibrahim a.s adalah dalam bidang aqidah, ibadah dan akhlak.Kelima, metode yang digunakan adalah keteladanan, metode praktek langsung, metode kasih sayang, metode dialog, dan metode doa. Keenam, periodesasi pendidikan bisa dibagi ke dalam dua bagian, yaitu pendidikan pra-natal (qabla wiladah) dan pasca-natal (ba’da wiladah).Pada masa Pranatal Nabi Ibrahim as mengutamakan istri yang shalehah dan berdoa kepada Allah agar dikaruniakan anak yang shaleh.Pada masa pasca-natal Nabi Ibrahim a.s dalam mendidik anak-anaknya senantiasa memanjatkan doa yang terbaik untuk pertumbuhan dan perkembangan anaknya
Treatment of humerus fracture with wise-lock implants
Authors: Kumar Prashant , Kumar Mohit , Rawat Pooja , Luthra Gaurav 
Published: October 2019

<p class="abstract"><strong>Background:</strong> Humerus fracture is a common fracture in aging population mainly occurring due to fall, high energy trauma and sports injury. Locking plate treatment is showing good results in stabilization of the fracture. The purpose of this study is to showcase the surgical treatment and results by using Auxein locking implants for the treatment of proximal humeral fracture.</p><p class="abstract"><strong>Methods:</strong> Prospectively 13 patients were treated with ORIF treatment (6 males, 7 females with an average age of 43.6years). Fracture type is classified as per the Muller AO classification of fracture, 6 patients had type 11-A1 and 7 patients had type 11-A2. 1 patient were felt under American Society of Anesthesiologists grade 2 have mild systemic disease. Clinical outcomes were assessed at 1year follow-up with visual analogue scale score at 4 week, 16 week, 24 week and 1 year.<strong></strong></p><p class="abstract"><strong>Results:</strong> The follow-up of patients was taken at 4<sup>th</sup>, 16<sup>th</sup>, 24<sup>th</sup> and 1 year bearing good clinical results. 2 patients were encountered with pain, these were elderly patients of the age 58 and 62 and had a history of other medical commodities. One patient reported of less weigh bearing ability which was relieved with physiotherapy.</p><p><strong>Conclusions:</strong> Open reduction internal fixation treatment with Pheelos 3.5 mm wise lock proximal humerus plate showed good results with improved performance and negligible complications. </p>
Deformalization as the immanent part of logical solving
Authors: Непейвода Николай Николаевич 
Published: October 2019

Deformalization is the part of logical process least investigated and studied. It is often non-trivial and hard task because of
subjective and objective complexities.

Subjective complexities connected with logic.
Deformalization is needed to present results of logical investigations to outsiders. Outsiders usually use languages and formalisms very far from logical ones.
Their thesaurus usually barely intersects with logical one.
Thus formulations on logical language cannot be appreciated and comprehended by outsiders and formulation of results needs to be completely replaced by non-logical. This task often is like to translating from one natural language into another with radically different semantic structure and system of notions (e.g. from Russian into Chinese and vice versa).

Subjective complexities connected with roles.
Systems of values of the problem solver and the decision consumer is radically different. Many aspects which were important during solution are out of scope of interests of the consumer. Many aspects which were "important" for the consumer are to be negligible for the solver but they are to be restored in presentation of the decision. This side of deformalization leads a bridge to the objective complexities.

Objective complexities.
Methods applied during formalization and solving induce "dual" methods are to be applied during deformalization.

General conclusions and propositions.
After analyzing whole process of logical solving in its unity it is possible to make some conclusions how logic can take a place which it is worth both in scientific analysis and in education.

Interesting in more detailed speculations of this matter are addressed to the Russian variant.
Electronic Medical Records for Discovery Research in Nonalcoholic Fatty Liver Disease
Authors: Kartoun Uri , Aggarwal Rahul , Perer Adam , Park Yoonyoung , Zhang Ping , Luo Heng , Dey Sanjoy , Corey Kathleen , Ng Kenney 
Published: October 2019

Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent yet under-diagnosed and under-discussed disease. Given that NAFLD has not been explored sufficiently compared with other diseases, opportunities abound for scientists to discover new biomarkers (such as laboratory observations, current comorbidities, behavioral descriptors) that can be linked to the development of conditions and complications that may develop at a later stage of the patient’s life. Methods: We analyzed IBM Explorys, a repository that contains electronic medical records (EMRs) of more than 50 million individuals. We used a classification algorithm that members of our group have previously validated to identify patients at a high probability for NAFLD. The algorithm identified more than 80,000 patients with a high probability for NAFLD who had at least 5 years of follow-up. We applied standard statistical methods (such as logistic regression and bootstrapping) and used Clinical Classifications Software (CCS) definitions to identify associations between a variety of covariates and disease outcomes. Results: Our methodology identified several thousand strongly statistically significant associations between covariates and outcomes in NAFLD. Most of the associations are known, but others may be new and require further investigation in subsequent studies. Conclusions: A discovery mechanism composed of standard statistical methods applied on a large collection of EMRs, confirmed known associations and identified potentially new associations that can act as biomarkers that might merit further research.
Development and validation of the Occupational Back Pain Prevention Behaviors Questionnaire in nursing personnel
Authors: Kazemi Seyedeh Somayeh , Tavafian Sedigheh-Sadat , Hidarnia Alireza , Montazeri Ali 
Published: October 2019

Abstract
Background: Occupational back pain is the most prevalent health problem among nurses that needs to be assessed by a valid and multi-factorial questionnaire. The purpose of the present study was to design and develop an instrument for assessing job-related back pain prevention behaviors among nursing professionals.
Methods: First an item pool of 49 items was generated. Then, content and face validity was carried out. Consequently, a cross-sectional study was conducted in Mazandaran, Iran. The questionnaire was distributed among a sample of nurses working in hospitals affiliated to Mazandaran University of Medical Sciences. Exploratory factor analysis was used to determine the factor structure of the questionnaire. Item-scale correlation matrix employed to examine the construct validity. The Cronbach’s alpha was estimated to assess the reliability and the intraclass correlation coefficient was calculated to examine stability.
Results: In all 155 nurses participated in the study. The mean age of respondents was 34.1 (SD = 7.66) years, and 83.2% were female. Six factors with 30 items emerged from the exploratory factor analysis: knowledge, attitude, self-efficacy, reinforcing factors, enabling factors and behavior that jointly accounted for %66.5 of variance observed. Item-scale correlation matrix showed satisfactory results lending support to construct validity of the questionnaire. The Cronbach’s alpha coefficient showed excellent internal consistency (alpha=0.92). The intraclass correlation coefficient with 2-weeks interval also indicated that the questionnaire has satisfactory stability (ICC = 0.97).
Conclusions: The findings showed that the Occupational Back Pain Prevention Behavior Questionnaire is a reliable and valid instrument for measuring occupational back pain prevention behaviors among nurses.
Keywords: Occupational Back Pain, Prevention behaviors, Psychometric evaluation, PRECEDE-PROCEED model, Nurse
The effectiveness of mesalazine therapy of ulcerative colitis of moderate severity in real clinical practice
Authors: Knyazev O. V. , Kagramanova A. V. , Lishchinskaya A. A. , Parfenov A. I. 
Published: October 2019

Aim of the study. To compare the efficacy of treatment of patients with moderate left-sided and overall affection ulcerative colitis (UC) receiving equivalent doses of mesalazines – Mesacol and Salofalk.Materials and methods. 90 UC patients of medium severity who received mesalazine Salofalk (group 1) were included, of which 41 (45.5%) were males and 49 (54.5%) females, mean age 35.8 ± 2.5 years, and 96 UC patients of medium severity who received mesalazine Mesacol (group 2), of whom 42 (43.75%) were males and 54 (56.25%) females, mean age 37.1 ± 3.1 years. Patient follow-up time was 12 weeks. The efficacy of the therapy was assessed taking into account 1) response to therapy in 2 weeks from the beginning of therapy; 2) achievement and maintenance of clinical remission (persistent remission) within 12 weeks after the beginning of therapy. Results and discussions. After 2 weeks 78 (86,7%) patients of the 1st group responded to the therapy with mesalazine Salofalc (stool frequency decreased to 4–6 t/day, presence of pathological impurities in the stool decreased, according to laboratory indices anemia and leukocytosis decreased, and the level of CRP and ESR decreased). Twelve patients (13.3%) did not have a proper response to therapy. In the 2nd group of patients receiving Mesacol mesalazine, 80 (83,4%) out of 96 patients responded to the therapy, and 16 patients (16,6%) did not respond. After 12 weeks, 78 (86.7%) of the 90 UC Group 1 patients who responded to mesalazine Salofalk treatment still had clinical remission. The Mayo index in the group decreased from an average of 7.98 ±0.11 to 2.9 ±0.24 points. After 12 weeks, in group 2 UC patients (n = 96), 80 patients (83.4%) who responded to Mesalazine Mesacol therapy also had clinical remission. The Mayo Index in Group 2 decreased on average from 7.8 ± 0.1 to 2.8 ± 0.25 points. One year after the start of Salofalk mesalazine therapy, clinical remission remained in 76 (84.4%) of the 90 UC patients who responded to therapy, of whom 32 (35.5%) had clinical endoscopic remission. In the second group of UC patients receiving Mesacol, clinical remission remained in 78 (82.0%) out of 96 patients who responded to therapy, clinical endoscopic remission in 32 (35.5%) patients with UC. When comparing the duration of remission among UC patients receiving mesalazine Salofalk and patients receiving mesalazine Mesacol, there was no statistically significant difference (p = 0.45).Conclusion. Mesalazines remain the first line of treatment for mild and moderate UC patients. Treatment of moderately active UC should start with oral mesalazine >2 g/day in combination with local mesalazine. Prolonged continuous use of Mesacol and Salofalk mesalazines for a year is comparable in efficacy.
Functionalized Bacterial Cellulose Microparticles for Drug Delivery in Biomedical Applications
Authors: Ullah Hanif , Badshah Munair , Correia Alexandra , Wahid Fazli , Santos Hélder A. , Khan Taous 
Published: October 2019

Background:
Bacterial cellulose (BC) has recently attained greater interest in various research fields,
including drug delivery for biomedical applications. BC has been studied in the field of drug delivery, such as
tablet coating, controlled release systems and prodrug design.

Objective:
In the current work, we tested the feasibility of BC as a drug carrier in microparticulate form for potential
pharmaceutical and biomedical applications.

Method :
For this purpose, drug-loaded BC microparticles were prepared by simple grinding and injection
moulding method through regeneration. Model drugs, i.e., cloxacillin (CLX) and cefuroxime (CEF) sodium salts
were loaded in these microparticles to assess their drug loading and release properties. The prepared microparticles
were evaluated in terms of particle shapes, drug loading efficiency, physical state of the loaded drug, drug
release behaviour and antibacterial properties.

Results:
The BC microparticles were converted to partially amorphous state after regeneration. Moreover, the
loaded drug was transformed into the amorphous state. The results of scanning electron microscopy (SEM)
showed that microparticles had almost spherical shape with a size of ca. 350-400 μm. The microparticles treated
with higher drug concentration (3%) exhibited higher drug loading. Keeping drug concertation constant, i.e., 1%,
the regenerated BC (RBC) microparticles showed higher drug loading (i.e., 37.57±0.22% for CEF and
33.36±3.03% for CLX) as compared to as-synthesized BC (ABC) microparticles (i.e., 9.46±1.30% for CEF and
9.84±1.26% for CLX). All formulations showed immediate drug release, wherein more than 85% drug was released
in the initial 30 min. Moreover, such microparticles exhibited good antibacterial activity with larger zones
of inhibition for drug loaded RBC microparticles as compared to corresponding ABC microparticles.

Conclusion :
Drug loaded BC microparticles with immediate release behaviour and antibacterial activity were
fabricated. Such functionalized microparticles may find potential biomedical and pharmaceutical applications.
Efektivitas Penggunaan Aplikasi Tiny-Scanner Dalam Model STAD Terhadap Hasil Belajar Peserta Didik Kelas 11 MIPA Pada Materi Transformasi Geometri di SMA Negeri 9 Yogyakarta
Authors: Lasmanawati Ati 
Published: October 2019

Tujuan Penelitian ini adalah untuk meningkatkan hasil belajar peserta didik di kelas XI.MIPA pada materi Transformasi Geometri melalui efektivitas penggunaan aplikasi Tiny Scanner dalam model STAD. Penelitian ini adalah penelitian jenis kuantitatif dengan metode quasi-eksperimen design tipe posstest-only control design, dilakukan pada peserta didik kelas XI.MIPA-4 (kelas eksperimen) dan kelas XI.MIPA-5 (kelas kontrol) untuk materi Transformasi Geometri Tahun Pelajaran 2018/2019. Tahapan penggunaan aplikasi Tiny Scanner dalam model STAD, yaitu 1) persiapan; 2) penyampaian informasi; 3) organisir peserta didik; 4) pemberian tugas; 5) membantu kerja kelompok dalam belajar; 6) menguji materi; 7) kuis; dan 8) penghargaan. Instrumen yang digunakan dalam penelitian terdiri dari lembar observasi, tes tertulis, dan tes praktek. Hasil penelitian menunjukkan bahwa efektivitas penggunaan Tiny Scanner dalam model STAD dapat meningkatkan hasil belajar peserta didik di kelas XI.MIPA pada materi Tranformasi Geometri. Efektivitas penggunaan aplikasi Tiny Scanner dilihat dari nilai rata-rata sikap peserta didik kelas eksperimen yang pada umumnya sudah mencapai predikat Sangat Baik (SB). Kompetensi pengetahuan nilai rata-ratanya sebesar 79,19 sudah melampaui KKM, dan nilai ini lebih tinggi dari kelas kontrol yang hanya sebesar 68,56. Capaian nilai rata-rata untuk kompetensi keterampilan sebesar 81,00 untuk kelas eksperimen dan kelas kontrol yang hanya sebesar 70,00. Berdasarkan hasil uji hipotesis pada taraf kesalahan α = 5%, n1 = 35, n2 -= 34, dk1 = 34, dan dk2 = 33 dengan nilai uji rata-rata pada kompetensi pengetahuan (thitung) adalah 3,109 dan ttabel = 2,033. Karena nilai thitung ttabel maka hasil ini uji hipotesis menunjukkan bahwa terdapat efektivitas penggunaan aplikasi Tiny Scanner dalam model STAD terhadap hasil belajar peserta didik di kelas XI.MIPA pada materi Transformasi Geometri Tahun Pelajaran 2018/2019.