bluuebunny/crossref_metadata_2025_split huggingface dataset:
A hybrid regionalization method based on canonical correlation analysis and cluster analysis: a case study in northern Iran
Authors: Ahani Ali , Mousavi Nadoushani S. Saeid , Moridi Ali 
Published: June 2019

AbstractThe performance of regionalization methods used for regional flood frequency analysis is affected considerably by the features used to identify the homogeneous regions (e.g., climatological, meteorological, geomorphological, and physiographic characteristics of the watersheds). In this study, a regionalization method is proposed that takes advantage of the two widely used techniques in regionalization of watersheds: canonical correlation analysis and cluster analysis. In the proposed method, the canonical correlation analysis is utilized to select or weight features that then will be used by a hybrid clustering algorithm for regionalization of watersheds. The proposed method is applied to Sefidrud basin, located in the north of Iran, to implement regionalization with two, three, four, and five regions. Performance assessment of the proposed method shows that all the options of the proposed method can be effective alternatives to some common regionalization methods to improve the homogeneity of the regions. The results indicate that the method can satisfy the homogeneity conditions approximately for all the regions which were identified in the study area.
Estimation of chlorophyll-a concentration using Landsat 8 in the Cassaffousth reservoir
Authors: Ledesma María Micaela , Bonansea Matías , Ledesma Claudia Rosa , Rodríguez Claudia , Carreño Joel , Pinotti Lucio 
Published: June 2019

Abstract
The physico-chemical and biological composition of a reservoir's effluents directly influences water quality. The values of variables such as high values of concentrations of chlorophyll-a (Chl-a) are indicators of pollution. The objective of this work was to monitor the trophic status and water quality of the Cassaffousth reservoir (Córdoba, Argentina) through the development of statistical models based on field data and satellite information. During 2016 and 2017, samples were taken bimonthly. Seven sampling sites were selected and physico-chemical and biological parameters were assessed. By using regression techniques, Landsat 8 information was related with field data to construct and validate a statistical model to determine the distribution of Chl-a in the reservoir (R2 = 0.87). The generated algorithm was used to generate maps which contained information about the dynamics of Chl-a in the entire reservoir. Remote sensing techniques can be used to expand the knowledge of the dynamics of the Cassaffousth reservoir. Moreover, these techniques can be used as baselines for the development of an early warning system for this and other reservoirs in the region.
Study on the price of water rights trading between agriculture and industry based on emergy theory
Authors: Zhang Wenge , Tan Li , Yin Huijuan , Guo Xinwei 
Published: June 2019

Abstract
A water rights trading scheme in China is currently in its initial stage of development, but is without a complete pricing mechanism. This paper proposes a pricing model for transfers of water rights from agriculture to industry in water-deficient areas of China. Both the cost price and the earnings price are considered and incorporated into the model. The cost price includes construction costs, operation and maintenance costs, renewal and reconstruction costs, and economic compensation for ecological damage. The earnings price is calculated according to a reasonable return coefficient and the difference in economic value of the water resources to the buyer and seller. The value of water resources was estimated based on emergy theory in accordance with the principle of mutual benefits equilibrium. This pricing model is then applied to the transfer of surplus water rights arising from agricultural water conservation schemes to industrial uses in the Southbank Ordos Irrigation Zone of the Inner Mongolia Autonomous Region. The results indicate that this pricing model could provide technical support to the scientific and reasonable pricing of water rights transactions in water-deficient areas and that it could play an active role in promoting the healthy development of future water markets.
Cannabidiol Adverse Effects and Toxicity
Authors: Huestis Marilyn A. , Solimini Renata , Pichini Simona , Pacifici Roberta , Carlier Jeremy , Busardò Francesco Paolo 
Published: June 2019

Background:
Currently, there is a great interest in the potential medical use of cannabidiol
(CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD
occurred in the 1970s and intensified recently with many discoveries about the endocannabinoid
system. Multiple preclinical and clinical studies led to FDA-approval of Epidiolex®, a purified CBD
medicine formulated for oral administration for the treatment of infantile refractory epileptic
syndromes, by the US Food and Drug Administration in 2018. The World Health Organization
considers rescheduling cannabis and cannabinoids. CBD use around the world is expanding for
diseases that lack scientific evidence of the drug’s efficacy. Preclinical and clinical studies also
report adverse effects (AEs) and toxicity following CBD intake.

Methods:
Relevant studies reporting CBD’s AEs or toxicity were identified from PubMed, Cochrane
Central, and EMBASE through January 2019. Studies defining CBD’s beneficial effects were
included to provide balance in estimating risk/benefit.

Results:
CBD is not risk-free. In animals, CBD AEs included developmental toxicity, embryo-fetal
mortality, central nervous system inhibition and neurotoxicity, hepatocellular injuries, spermatogenesis
reduction, organ weight alterations, male reproductive system alterations, and hypotension,
although at doses higher than recommended for human pharmacotherapies. Human CBD studies for
epilepsy and psychiatric disorders reported CBD-induced drug-drug interactions, hepatic abnormalities,
diarrhea, fatigue, vomiting, and somnolence.

Conclusion:
CBD has proven therapeutic efficacy for serious conditions such as Dravet and
Lennox-Gastaut syndromes and is likely to be recommended off label by physicians for other conditions.
However, AEs and potential drug-drug interactions must be taken into consideration by
clinicians prior to recommending off-label CBD.
Styrylquinoline – A Versatile Scaffold in Medicinal Chemistry
Authors: Musiol Robert 
Published: June 2019

Background: :
Styrylquinolines are characteristic fully aromatic compounds with flat,
rather lipophilic structures. The first reports on their synthesis and biological activity were published
roughly a century ago. However, their low selectivity, unfavorable toxicity and problems
with their mechanism of action significantly hampered their development. As a result, they have
been abandoned for most of the time since they were discovered.

Objective: :
Their renaissance was observed by the antiretroviral activity of several styrylquinoline
derivatives that have been reported to be HIV integrase inhibitors. Subsequently, other activities
such as their antifungal and anticancer abilities have also been revisited.

Methods:
In the present review, the spectrum of the activity of styrylquinolines and their use in
drug design is presented and analyzed.

Results:
New properties and applications that were reported recently have re-established
styrylquinolines within medicinal and material chemistry. The considerable increase in the number
of published papers regarding their activity spectrum will ensure further discoveries in the field.

Conclusions:
Styrylquinolines have earned a much stronger position in medicinal chemistry due to
the discovery of their new activities, profound mechanisms of action and as drug candidates in
clinical trials.
The Vest™ High-Frequency Chest Wall Oscillation System Compared with Manual Chest Wall Physiotherapy for Managing Airway Clearance in Patients with Complex Neurological Disorders: A UK-based Cost-Effectiveness Analysis
Authors: Javanbakht Mehdi , Mashayekhi Atefeh , Montazeri Mohammad , Rezai Hemami Mohsen , Branagan-Harris Michael 
Published: June 2019

Background:
Weakness in the muscles used to breathe and swallow can lead to difficulties with airway clearance for people with neurological disorders including neuromuscular disease and cerebral palsy. This can lead to aspiration and other respiratory problems which are the leading causes of death in patients with complex neurological disorders. The Vest™ system supports airway clearance through the use of High-Frequency Chest Wall Oscillation (HFCWO) to loosen secretions in the chest by reducing their viscosity.

Objective:
To assess the cost-effectiveness of the Vest™ system versus Manual Chest Wall Physiotherapy (MCWP) for airway clearance in patients with neurological disorders including neuromuscular disease and cerebral palsy.

Methods:
A decision-analytic Markov model was developed to estimate the cost-effectiveness of HFCWO and MCWP over 5- and 10-year time horizons. Costs were estimated from the perspective of the UK National Health Service and personal social services. The main input parameters in the model were: rates of respiratory infection, respiratory-related hospitalisation, antibiotic use for respiratory infection and cost of the Vest™ system. The input parameters were informed by existing clinical guidelines and literature. Sensitivity analyses were conducted to explore uncertainties around the input parameters.

Results:
Over 5- and 10-year time horizons, the Vest™ system results in more quality-adjusted life-years and lower costs per patient. The Vest™ system has a high probability of being cost-effective (>98%) at willingness-to-pay thresholds of £20,000 and £30,000. The estimated average cost saving per patient over a 5-year time horizon is £5,660 (SD = £2362). Our results show that the Vest™ system may result in approximately £6 million cost savings per 1,000 patients with complex neurological disorders in 5 years. Per 1,000 patients, 2,442 hospital admissions and 49,868 bed days could be averted with the use of the Vest™ system. Our results were generally robust to the sensitivity analyses performed.

Conclusion:
The Vest™ system results in fewer respiratory infection episodes and hospitalisations, and thus less National Health Service (NHS) resource use, than current practice. Therefore, it is highly likely to be a cost-saving strategy.
An Overview of Neuromuscular Junction Aging Findings in Human and Animal Studies
Authors: Khosa Shaweta , Trikamji Bhavesh , Khosa Gurveer S. , Khanli Hadi M. , Mishra Shri K. 
Published: June 2019

Background:Aging is a complex irreversible process that is not only related to an individual’s genetic make-up but also to lifestyle choices and environmental exposures. Like every other structure in human body, the Neuromuscular Junction (NMJ) is not averse to aging.Objectives:The prime objective is to analyse the microscopic and macroscopic changes at the NMJs with aging.Methods:For the purpose of review we evaluated data from resources like Pubmed, Ovid, UCLA libraries and USC libraries.Results:We review various morphological, physiological, immunological, and biochemical changes in NMJs with aging and their management.Conclusion:The alterations in NMJs secondary to aging are inevitable. It is vital that neurologists clearly understand the pathophysiology of NMJ aging and differentiate between physiological and pathological effects of aging. With the current knowledge of science, the changes in NMJ aging can be better prevented rather than cured.
Technology-Enabled Self-Monitoring of Chronic Obstructive Pulmonary Disease With or Without Asynchronous Remote Monitoring: Protocol for a Randomized Controlled Trial
Authors: Stamenova Vess , Yang Rebecca , Engel Katrina , Liang Kyle , van Lieshout Florence , Lalingo Elizabeth , Cheung Angelica , Erwood Adam , Radina Maria , Greenwald Allen , Agarwal Payal , Sidhu Aman , Bhatia R Sacha , Shaw James , Shafai Roshan , Bhattacharyya Onil 
Published: June 2019

Background
Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality worldwide. Reducing the number of COPD exacerbations is an important patient outcome and a major cost-saving approach. Both technology-enabled self-monitoring (SM) and remote monitoring (RM) programs have the potential to reduce exacerbations, but they have not been directly compared with each other. As RM is a more resource-intensive strategy, it is important to understand whether it is more effective than SM.

Objective
The objective of this study is to evaluate the impact of SM and RM on self-management behaviors, COPD disease knowledge, and respiratory status relative to standard care (SC).

Methods
This was a 3-arm open-label randomized controlled trial comparing SM, RM, and SC completed in an outpatient COPD clinic in a community hospital. Patients in the SM and RM groups recorded their vital signs (oxygen, blood pressure, temperature, and weight) and symptoms with the Cloud DX platform every day and were provided with a COPD action plan. Patients in the RM group also received access to a respiratory therapist (RT). The RT monitored their vital signs intermittently and contacted them when their vitals varied outside of predetermined thresholds. The RT also contacted patients once a week irrespective of their vital signs or symptoms. All patients were randomized to 1 of the 3 groups and assessed at baseline and 3 and 6 months after program initiation. The primary outcome was the Partners in Health scale, which measures self-management skills. Secondary outcomes included the St. George's Respiratory Questionnaire, Bristol COPD Knowledge Questionnaire, COPD Assessment Test, and modified-Medical Research Council Breathlessness Scale. Patients were also asked to self-report on health system usage.

Results
A total of 122 patients participated in the study, 40 in the SC, 41 in the SM, and 41 in the RM groups. Out of those patients, 7 in the SC, 5 in the SM, and 6 in the RM groups did not complete the study. There were no significant differences in the rates of study completion among the groups (P=.80).

Conclusions
Both SM and RM have shown promise in reducing acute care utilization and exacerbation frequencies. As far as we are aware, no studies to date have directly compared technology-enabled self-management with RM programs in COPD patients. We believe that this study will be an important contribution to the literature.

Trial Registration
ClinicalTrials.gov NCT03741855; https://clinicaltrials.gov/ct2/show/NCT03741855

International Registered Report Identifier (IRRID)
DERR1-10.2196/13920
DEVELOPMENT STRATEGY OF JOGGING TRACK AS TOURIST ATTRACTION IN ANGGABAYA VILLAGE, PENATIH DENPASAR
Authors: Wirawan Putu Eka , Sudiarta I Nyoman 
Published: June 2019

Development of tourism destination should be supported by the potential of tourism activities; one of them is sports tourism. Sports tourism is a tourism activity by doing sports activities as a fundamental and significant part of a vacation. Sanur Tourism Destination, known by many tourists as a place where they can perform sports activities as a mode of movement, has tourism potential that supports the development of sports tourism. That potential is also supported by the planning and activities of stakeholders in order to develop this tourism for society and tourists in realizing sustainable tourism (green tourism). The purposes of this research were: 1) to discover the potential that makes Sanur Tourism Destination has the opportunity to develop cycling tourism. 2) to find out the benefits of cycling tourism towards Sanur Tourism Destination. The research methodology used was descriptive research methodology. It aimed to obtain a complete profile or description of relevant aspects of an interesting phenomenon, which occurs in an individual, organization, industry, or other things. Techniques for collecting the data were direct observation, in-depth interview and documentation/literature studies.The results showed that: 1) the potential that makes Sanur Tourism Destination has the opportunity to develop cycling tourism. 2) the benefits of cycling tourism towards Sanur Tourism Destination. The recommendation of this research is expected to provide input to Stakeholder and Government in analyzing the potential of Sanur Tourism Destination in developing sports tourism as a friendly destination both in its activities and way of traveling, therefore, it is useful for the welfare of society. The results of this research could also help local people and government in reviewing the strategy of sports tourism planning in Sanur Tourism Destination in realizing sustainable tourism planning.
POTENTIALS OF PALUNGAN SALT FARMING IN THE DEVELOPMENT OF CULTURAL TOURISM AND COMMUNITY-BASED EDUCATION IN THE VILLAGE OF TEJAKULA
Authors: Widhiarini Ni Made Ayu Natih , Ariastini Ni Nengah , Permanita Ni Putu Feby Devira , Semara I Made Trisna 
Published: June 2019

Palungan salt farming is one of commodity that is still dominated by coastal communities in Tejakula Village. However, since 2010 the number of palungan salt farmers has degraded from 200 farmers to 21 farmers. This resulted in the production of salt manger decreased. On the other hand, salt is one of the foodstuffs needed by various parties for both consumption and industrial needs. Although the Government has issued a policy to empower traditional salt farming through PUGAR, but until now the implementation has not been maximized. The aims of this research is to identify the potential of internal and external physical environments in Tejakula Village to consideration in the effort to conserve local wisdom in synergy with sustainable tourism development. Using the descriptive qualitative research method, Tejakula Village has internal and external potential that is useful to be developed towards the development of living museum as cultural and educational tourism in order to conserve local wisdom and improve the economic level of the community in Tejakula Village.
Vida Cotidiana, Apoyo Social Y Experiencia de Soledad en Personas Mayores del Área Metropolitana de Buenos Aires, Argentina
Authors: Pochintesta Paula 
Published: June 2019

Con el propósito de comprender el fenómeno de la viudez en el envejecimiento, se realizó un estudio cualitativo a partir de 10 entrevistas en profundidad realizadas a viudos/as de 65 y más años, residentes del Área Metropolitana de Buenos Aires. Para ello se contactaron casos en diferentes instituciones (públicas, privadas y de ONG’s) como, hogares, centros de día, centros de jubilados y mutuales. También se entrevistaron viudos/as que no concurrían a instituciones. El trabajo de campo se realizó entre 2014 y 2015.Se delimitaron criterios para poder reconstruir: a) cambios en la organización de la vida cotidiana; b) fuentes de apoyo social percibido y; c) emociones sentidas a partir de la pérdida del cónyuge. Se evidenció que la viudez constituye un punto de inflexión en la vejez. Se identificaron diferencias de género en cuanto a la reorganización de las cuestiones domésticas. Las similitudes tuvieron que ver con el abandono de las actividades recreativas compartidas con el cónyuge. AbstractA qualitative study was conducted with the purpose of understanding the phenomena of widowhood in old age. It was based on 10 in-depth interviews with65+ year-old widowers and widows residing in the Metropolitan Area of Buenos Aires. The subjects were contacted through multiple organizations (public and private institutions, and NGOs), such as nursing homes, senior centers, and mutual organizations. Widowers and widows currently not attending any institution were also interviewed. Fieldwork was carried out between 2014 and 2015.Criteria were defined in order to reconstruct: a) the changes in the organization of daily life; b) the sources of perceived social support; and c) the emotions experienced after the death of the spouse. The study found that widow hood is a turning point in old age. Gender differences were identified in relation to the reorganization of domestic affairs. The similarities between genders involved the withdrawal from leisure activities shared with the spouse.
Sensorial descriptors for CATIE and Folk pigeon pea (Cajanus cajan) salad determined through a focus group
Authors: Amerling Quesada Carolina , Andrés Carmen 
Published: June 2019

RESUMEN: El gandul (Cajanus cajan) es conocido por su capacidad de fijar nitrógeno en el suelo, así como proteger las cuencas hidrográficas y su alto valor nutricional. En Costa Rica se cultiva en San Carlos, Costa Rica por la Asociación de Productores de Gandul, Raíces y Tubérculos. Con el objetivo de apoyar los esfuerzos de mercadeo, se utilizó un grupo focal para probar una ensalada de gandul y otros. La ensalada fue evaluada por diez consumidores según las tendencias del mercado, competidores, ingredientes, degustación, material de empaque, apariencia y venta del producto. El producto fue altamente aceptado y descrito por los consumidores como versátil y la tendencia en cuanto a la adquisición del producto eran placer, salud y conveniencia. Prefirieron el empaque biodegradable y con información nutricional. Su vida útil más larga en comparación con otras ensaladas es una ventaja, aunque sea más costosa. La aceptación del producto sugiere su posibilidad de éxito y la importancia de continuar investigando otros aspectos. PALABRAS CLAVE: Gandul, grupo focal, formulación de producto, posicionamiento en el mercado, descriptores sensoriales.
Características de morbilidad en funcionarios de una universidad estatal de Costa Rica, América Central
Authors: Arce Lourdes 
Published: June 2019

La morbilidad constituye un indicador importante de las causas de mortalidad de una población y permite enfocar las acciones en salud preventiva para disminuir los riesgos. Aquí presento datos del servicio médico de una universidad estatal de Costa Rica. Sus participantes fueron los funcionarios que acudieron a consulta del 19 de enero del 2009 al 14 de diciembre del 2012. Se analizó la población total consultante, usando como instrumentos 2 010 expedientes médicos electrónicos, se realizó un reporte y posterior el análisis estadístico en el programa SPSS. Los hallazgos principales fueron que el 53% de la población consultó entre 1 a 10 consultas anuales, los dos grandes grupos de edad: adultos jóvenes y adultos, consultan en igual proporción; hay ciclos semanales y mensuales, correspondientes a los reportados en otros servicios de salud a nivel nacional. Las causas de consulta coinciden en las reportadas a nivel nacional, por lo que se mantiene la hipótesis de que la ocupación y el nivel socioeconómico (presentados en algunos otros estudios como factores determinantes de la morbilidad) en esta población no presentan un patrón distinto con respecto al patrón nacional. Muchas de las consultas realizadas están relacionadas con pobres hábitos de higiene, mala dieta y sedentarismo, así como poca higiene postural.
Si nos educan en la igualdad, creceremos más libres
Authors: Bard Wigdor Gabriela , Bonavitta Paola 
Published: June 2019

En el presente artículo se indaga acerca de las formas dominantes de socializar a niños y niñas dentro del sistema patriarcal, en sectores de clase media de la ciudad de Córdoba, Argentina. La investigación se sustenta en un interés profundamente subjetivo, personal y desde una posición particular: somos mujeres heterosexuales, feministas y madres. Reflexionamos de manera situada sobre la crianza y las diferentes maneras en las que se llega a ser varón; especialmente, sobre la reproducción de la masculinidad dominante.