bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sīra and Exegesis, Qur’ān 30:1-5
Authors: Jarrar Maher 
Published: November 2024

Drawing upon the methodology sanad-cum-matn analyses of early source criticism, this study explores and traces the history of the first five āyas of Sūrat al-Rūm (Q 30:1–5) aiming to recover the historicity of the material, probe a philological enquiry, and discern a possible Ur-matn that was in circulation in the first half of the second/eighth century.
These first five verses (āyas) posed a number of problems for early Muslim scholars, and have likewise intrigued modern students of Islam. The difficulties originated from a variety of questions pertaining to interlaced issues of dating (chronology), the occasion of its revelation, a “legal-ethical” perspective, and specifying the locality alluded to in the verses, as well as language. For early Muslim scholars these verses offered a juncture for an exercise in finding a link between Qurʾānic exegesis and maghāzī-sīra traditions.
Contribution to the knowledge of Chinese Gryllacrididae (Orthoptera: Ensifera: Stenopelmatoidea) XXVI: New additions based on the specimens from Southern China
Authors: LUO TING , ZHANG HUI , BIAN XUN 
Published: November 2024

In this paper, we describe four new species based on the specimens from southern China: Glolarnaca flata sp. nov., Larnaca (Larnaca) nigrimargis sp. nov., Phryganogryllacris guangxiensis sp. nov. and Tenuigryllacris hainanensis sp. nov. In addition, the female sexes of four known species are described for the first time, namely: Apterolarnaca nigrifrontis Bian & Shi, 2016, Apterolarnaca quadrimaculata Bian & Shi, 2016, Dracogryllacris zhoui (Pang, Zhang & Bian, 2023) and Glolarnaca nigrimacula Yang, Lu & Bian, 2021. Also, two new synonyms (Apterolarnaca truncatoloba (Li & Liu, 2015) = Apterolarnaca spiculoproceris Zhang, Lu & Bian, 2022 syn. nov. and Marthogryllacris erythrocephala maculatis (Liu, Lu & Bian, 2022) = Marthogryllacris jinpingensis (Zhang & Bian, 2023) syn. nov.) are proposed based on molecular data. All the specimens are deposited in Guangxi Normal University.
The Liability of Informality and De-internationalisation During the COVID-19: International Evidence
Authors: Doan Ngoc Thang , Tran Ngoc Mai , Doan Van Ha , Mai Huong Giang 
Published: November 2024

This author investigates the effect of the liability of informality on a firm’s de-internationalisation using cross-country firm-level data. De-internationalisation reflects an export reduction in which firms decrease their overseas sales. Firms that start operating in the informal sector but then switch to the formal sector tend to de-internationalise more than those established as registered businesses. The effect becomes pronounced for small and medium-sized enterprises and firms that do not adopt digital transformation. Our findings indicate that informality imposed a liability on firms, especially during the COVID-19 period, and this is likely to persist over time. JEL Codes: G32, O17, F23, M16
Evolution of Master of Public Health Core Curriculum: Trends and Insights
Authors: Pennel Cara L. , Agana-Norman Denny Fe G. , Stalnaker Leslie A. , Wiltz-Beckham Dana , Luna Marisol 
Published: November 2024

Objectives: Revised accreditation criteria from the Council on Education for Public Health (CEPH) in 2016 prompted schools and programs of public health to shift their master of public health (MPH) core curricula. Our objective was to provide data on revisions to MPH core curricula at CEPH-accredited schools and programs of public health and other descriptive statistics on the MPH core curriculum and required courses as of 2023. Methods: We analyzed data from 67 accredited schools of public health and 130 accredited public health programs to assess changes from 2016 to 2023 in the MPH core curriculum. We examined the number of courses, the proportion of credit hours in the core curriculum, core curriculum composition, and course types. Results: Almost half (49.2%) of schools, but only 16.9% of programs, made extensive changes to their MPH core curricula, an overall increase of 153.6% from 2020 to 2023. Approximately one-fifth of schools and programs made few to no changes to their core curricula and retained core courses in the 5 former core disciplines. On average, core curriculum credit hours comprised 37.8% of total credit hours for schools and 51.7% for programs. Half (50.0%) of all programs in the sample offered single-concentration MPH degrees. Schools and programs were more likely to continue requiring traditional biostatistics (81.7%) and epidemiology (81.2%) courses in the core curriculum compared with environmental health (69.0%), social and behavioral health (61.9%), and health policy and management (42.1%). Conclusions: Most schools and programs modified their MPH core curricula, reflecting a departure from traditional public health courses toward innovative approaches to ensure knowledge and skill proficiency of graduates. Future research will determine if these curricular changes improve the knowledge and skill proficiency of public health graduates and the workforce.
A comparison between single and fractionated doses of albumin-bound paclitaxel in the treatment of advanced esophageal cancer: A multicenter case–control study
Authors: Ren Jing , Wang Ke , Zhao Jian , Xu Chang , Liu Changqing , Wang Yusheng , Wang Guangyu 
Published: November 2024

Purpose At present, albumin-bound paclitaxel combined with platinum is the standard first-line treatment option for advanced esophageal cancer (EC). However, following a hospitalization surge, clinicians may prefer to use albumin-bound paclitaxel as a single dose. The present study aimed to investigate the survival of patients with advanced EC when treated with single or fractionated doses of albumin-bound paclitaxel. Methods We collected survival data of patients with advanced first-line EC who had used albumin-bound paclitaxel with or without other treatment regimens from January 2018 to September 2023 at the Harbin Medical University Cancer Hospital and the Shanxi Province Cancer Hospital. The patients were divided into two groups according to the frequency and dose of albumin-bound paclitaxel administration, namely the abraxane fractional administration group (A group, 27 patients) and the abraxane single administration group (B group, 182 patients). Results The median progression-free survival (PFS) was 9.0 months in both groups ( p = 0.35), and the median overall survival (OS) was 21.0 months in A group and 18.0 months in B group ( p = 0.61). The objective response rate was 37% in A group and 25% in B group ( p = 0.314), and the disease control rate was 89% in A group and 83% in B group ( p = 0.580). The incidence of grade 3 or higher treatment-related adverse events was 15% in both groups. Conclusion Albumin-bound paclitaxel treatments showed no statistically significant differences in the PFS or OS. They were considered safe, whether administered as a single dose or in fractionated doses.
The association between sibling ambivalence and well-being in older adulthood: The role of sibling gender composition
Authors: Lee Jeenkyoung , Gilligan Megan , Neppl Tricia K. , Stocker Clare M. , Conger Katherine J. 
Published: November 2024

Family scholarship has documented negative associations between ambivalence and well-being in the context of parent-adult child relationships. As sibling ties remain salient throughout later life, ambivalence experienced in sibling relationships might also be related to older adult well-being. The purpose of this study was to examine the associations between sibling ambivalence and both psychological and physical well-being of older adults, as well as differences in these links by sibling gender composition. Data came from 702 older adults (392 women) who were 64.58 years old on average ( SD = 4.51). Structural equation modeling using FIML revealed that participants who felt more ambivalence toward their siblings reported poorer psychological well-being. However, a multiple group analysis showed that this association was only significant for brother-brother pairs. Findings suggest the need to further investigate the implication of sibling ambivalence for psychological well-being in later life, especially for brothers.
Time and headache: Insights into timing processes in primary headache disorders for diagnosis, underlying pathophysiology and treatment implications
Authors: Gonzalez-Martinez Alicia , Ray Jason C. , Haghdoost Faraidoon , Ashraf Usman , Cerrahoglu Sirin Tuba , Dantes Mia Catherine , Gosalia Helin , Hwang Heewon , Kim Jee Min , Lange Kristin Sophie , Jennysdotter Olofsgård Felicia , Caronna Edoardo , Pozo-Rosich Patricia ,   On behalf of International Headache Academy of the International Headache Society (IHS-iHEAD)
Published: November 2024

Background Time in headache disorders is crucial for diagnosis and gives insight into headache pathophysiology. Objective To summarize published studies which describe timing processes in both attack presentation (onset, duration) and disease characterization (age of onset, evolution over time) in primary headache disorders and link to pathophysiology. Methods A comprehensive search was conducted through Ovid MEDLINE(R) and PubMed, focusing on English-language articles from 1946 to 2023 to write the review. The International Classification of Headache Disorders, 3rd edition provided the framework for the review of primary headache disorders (migraine, tension-type headache and cluster headache). Results Attack presentation: Migraine attacks exhibit significant circadian and infradian rhythms, influenced by hormonal levels, light sensitivity, and hypothalamic activation. Tension-type headache lacks clear chronobiological patterns, with limited understanding of its underlying mechanisms. Cluster headache displays a distinct circannual pattern, with attacks often occurring at night and relevant involvement of the hypothalamus. Disease characterization: Age of onset exhibits the earliest peak in migraine; frequency and typical features of primary headache disorders decrease over time. Conclusion This comprehensive analysis of time patterns in primary headache disorders underscores their role in phenotyping, understanding and treating primary headache disorders, offering promising avenues for advancing and tailoring headache management.
Test Validity of a Single-Item Food Insecurity Screening Assessment Among College Students
Authors: Jarvis Jocelyn E. , Perez Jacqueline , Himmelgreen David , Dumford Amber D. , Conner Kyaien , Stern Marilyn , DeBate Rita 
Published: November 2024

Purpose Given the high prevalence of food insecurity among college students, there is an interest in identifying whether the use of a single item can adequately screen for food insecurity. The current study aimed to determine the validity of a single-item food insecurity screening question among college students. Design Cross-sectional study exploring food insecurity among racial and ethnic undergraduate college students. Setting Large urban U.S. research university. Sample Undergraduate students (n = 667) 18 years or older. Measures Food Insecurity screening was assessed via a single-item from the USDA Household Food Security Short Form (USDA FSSM-SF). Food security was assessed via the USDA FSSM-SF, a validated six-item scale that assesses food insecurity and hunger. Analysis Logistic regression assessed the validity of the single-item food insecurity question tested against the USDA FSSM-SF. Results The full model was statistically significant, χ2(1) = 161.44, P < .001 explaining 54.5% of the variance in food insecurity status correctly classifying 95.7% of cases. Sensitivity of the model was found to be 97.6%; specificity was found to be 69.6%. Positive predictive value was calculated to be 97.74%; negative predictive value was computed to be 68.09%. Conclusion Results support for the test validity of a single-item screening question that can be used to detect food insecurity among college students and inform secondary prevention programs aimed at food insecurity.
Enteral tube administration of extemporaneously compounded suspensions of venetoclax according to an institutional medication use process
Authors: Haque Sakib T. , Bubalo Joseph S. 
Published: November 2024

Introduction Venetoclax is a potent oral oncology drug (OOD) frequently used to treat hematologic cancers due to its convenience and high efficacy. However, some patients cannot tolerate solid oral formulations, requiring a reformulated version of venetoclax for effective administration. Currently, there is limited information in the literature regarding the extemporaneous compounding of venetoclax. Methods We present our institution's medication use process (MUP) for preparing compounded suspensions of venetoclax for patients with dysphagia who cannot tolerate solid oral formulations. This report has two main aims: to review our MUP from design to implementation, illustrated with real patient cases, and to present it as a strategy for administering venetoclax-based therapies to patients with dysphagia or feeding tubes. From February 2020 to January 2024, 17 patients received venetoclax through the standard MUP, with four developing tumor lysis syndrome (TLS). This study describes their clinical courses and evaluates their responses to the compounded suspensions, considering the uncertain effects of venetoclax prepared through this method. Results The four patients received venetoclax suspensions during hospitalization due to swallowing difficulties or nutritional support needs. We prepared extemporaneous venetoclax suspensions to ensure continuous therapy, thus avoiding treatment interruptions. TLS was managed using rasburicase and prophylactic allopurinol. Conclusions The clinical outcomes indicate that the current MUP provides a practical approach to administering venetoclax for dysphagic patients. However, additional research is needed to determine if there are pharmacokinetic differences in the bioavailability of venetoclax between oral and enterally delivered formulations. Further studies will help inform best practices for patient care.
Long-term results of endovascular versus open retroperitoneal repair associated with ERAS protocol for abdominal aortic aneurysms
Authors: Ciofani Lorenzo , Acciarri Pierfilippo , Ricci Roberta , Tagliabracci Francesca , Pederzani Emma , Azzolina Danila , Traina Luca 
Published: November 2024

Objectives Although the endovascular management of infrarenal abdominal aortic aneurysms (AAAs) is widely performed, many studies have shown better long-term results with open graft repairing, mostly focusing on the classical open repair with midline access. This study aims to evaluate long-term results comparing EVAR (endovascular aneurysm repair) and surgical open repair with retroperitoneal access associated with ERAS (Enhanced Recovery After Surgery) protocol. Methods A retrospective analysis of 156 patients treated for AAA between 2015 and 2018 was conducted. Clinical and demographic characteristics of the two groups were homogeneous except for age, which was significantly higher in patients belonging to the EVAR one, and for previous laparotomies. A total of 100 patients (58.7%) underwent open retroperitoneal repair (ORR group), and 56 (42.3%) underwent EVAR. A mean of 51 ± 28 months of follow-up was conducted. This study aims to evaluate long-term survival by comparing EVAR (endovascular aneurysm repair) and surgical open repair with retroperitoneal access associated with ERAS (Enhanced Recovery After Surgery) protocol. Secondary aims evaluate differences between the two techniques regarding late complications, need for re-interventions, and perioperative results. Results Freedom from all-cause mortality, calculated with Kaplan–Meier survival curves equalizing the two population with a Covariate Propensity Score, showed significant better survival rates at 1, 3, and 5 years in ORRs then in EVARs. Late complications (>30 days) and need for late re-intervention rates were greater in the EVAR group (6 late re-interventions needed vs 0 in the ORR group). Perioperative results show longer mean length of hospital stay in patients belonging to the ORR group (5 days vs 2) and significantly higher in-hospital-complication rate. Conclusions The long-term comparison between EVAR and open retroperitoneal repair shows significantly better late outcomes in the ORR group. The perioperative course appears significantly better in EVARs but anyway good in ORRs when a perioperative protocol as ERAS is applied. In a selected population of young patients fit for surgery, the retroperitoneal surgical approach should be highly taken into account in the therapeutical choice.
The perceptions of study abroad coordinators about digitalisation and Erasmus + virtual mobility
Authors: Konaklı Tuğba , Alkanat Akman Tuba , Mert Mahmut , Yuksel Dogan 
Published: November 2024

Most study abroad research focused on the experiences of students, perceptions of study abroad coordinators received little attention in research. Addressing this gap, this study examines how changes after 2020 (i.e. digitalisation of the Erasmus + processes and virtual mobility) impacted the perceptions of study abroad coordinators ( N = 23) in a large public university in Turkiye. An open-ended online questionnaire was prepared and shared with the participants who were active in the last 4 years and who experienced both traditional and virtual mobility processes and analysed via the content analysis method. Our results revealed that our participants mostly welcomed changes in digitalisation and virtual mobility in terms of their impact on their duties and responsibilities. However, they thought that the impact of virtual mobility was limited on their students’ academic, communicative and cultural development. Our study also includes a discussion of these findings and implications for mobility staff and/or administrators.
Real-time intervention to increase daily chlorhexidine bathing and reduce central line–associated bloodstream infections
Authors: Krier Brad A , Bhandari Pawan , Brooks Ashley M , Schultz Kristin J , Zarbano Jonna J , Anil Gokhan 
Published: November 2024

Background After an increase of central line–associated bloodstream infections (CLABSIs) at our community hospital in 2021, a case-control study suggested that patients with CLABSIs were 3.0 times more likely to have missed daily chlorhexidine gluconate (CHG) bathing than patients without CLABSIs. Objective To increase the rate of daily CHG bathing in hospitalized patients with central lines and subsequently reduce the number of CLABSIs. Methods Our pre-post intervention was launched on September 2022 and consisted of enhancements to the electronic health record (EHR) to simplify the identification of overdue CHG bathing instances to increase compliance, and therefore decrease the CLABSI rate at our hospital. A workflow was implemented Monday–Friday utilizing these EHR enhancements for active surveillance to engage frontline nursing staff and address gaps in care in real time. Results After the initiative was implemented, adherence to daily CHG bathing increased from 94.9% to 95.3%, with a considerable disparity between weekdays (97.6%) and weekends (89.3%). After weekend data were excluded, the post-intervention increase in the adherence rate was statistically significant ( p = .003). Discussion This initiative underscored the importance of involving health care informatics partners and showed how technology can bridge gaps in health care quality. Outreach and reminders effectively improved CHG bathing adherence by emphasizing the importance of consistent communication and follow-up.
SUNLAND: a randomized, double-blinded phase II GERCOR trial of sunitinib versus placebo and lanreotide in patients with advanced progressive midgut neuroendocrine tumors
Authors: Hammel Pascal , Smith Denis , Afchain Pauline , Dominguez-Tinajero Sophie , Seitz Jean-François , Lievre Astrid , Van Cutsem Eric , Assenat Eric , Di Fiore Frédéric , Peeters Marc , Sobhani Iradj , Raymond Eric , Charton Emilie , Vernerey Dewi , De Mestier Louis , Lombard-Bohas Catherine 
Published: November 2024

Background: Sunitinib, a multitarget tyrosine kinase inhibitor, showed encouraging antitumor activity and manageable toxicity in patients with advanced midgut neuroendocrine tumors (NETs) in earlier results from phase I and II trials. Patients and methods: In this phase II trial, patients with a nonresectable grade 1 or 2 midgut progressive NET and Eastern Cooperative Oncology Group performance status 0–1 were randomly assigned 1:1 to receive 37.5 mg sunitinib or a placebo, combined with 120 mg lanreotide autogel every 28 days. The planned sample size was 104 patients. The primary outcome was investigator-assessed progression-free survival (PFS). Results: The study was stopped early because of insufficient patient recruitment. Between January 2013 and December 2016, 44 patients were enrolled and received sunitinib ( n = 22) or placebo ( n = 22). The median age was 63.7 years ( Q1– Q3 range, 56.6–68.1) and 26 patients (59.1%) were male. The main localization was ileum ( N = 37, 84.1%) and the majority were grade 2 ( n = 25, 56.8%). The median follow-up was 36.7 months (95% confidence interval (CI) 34.6–48.2). The median PFS was 9.84 months (95% CI 6.8–23.3) with sunitinib and 11.47 months (95% CI 5.4–15.3) with placebo (hazard ratio (HR) = 0.80, 95% CI 0.41–1.56, p = 0.51). There was no difference in overall survival between treatment arms (HR = 0.81, (95% CI 0.32–2.01), p = 0.64). The objective response rate was 9.1% with sunitinib and 0.0% with placebo, and 19 patients (86.4%) had stable disease. Thirty-nine patients (88.6%) completed the baseline QLQ-C30 questionnaire. Baseline health-related quality of life level was similar between treatment arms, except for physical and emotional functioning which were higher ( p = 0.089) and lower ( p = 0.023) in the sunitinib arm, respectively. Trends toward longer time until a definitive deterioration in favor of the sunitinib arm were observed for 10 out of 15 dimensions (HRs < 1), with a significant result for financial difficulties (HR = 0.31, (90% CI 0.10–0.94)). Twenty-seven patients (61.4%) had at least one adverse event grade ⩾3 (sunitinib: 72.7%, placebo: 50.0%), with only one patient grade 4 for hypertension and vomiting. Eleven deaths non-related to treatment occurred (sunitinib arm: n = 5, placebo arm: n = 6). Conclusion: Our study does not provide enough evidence to conclude the role of sunitinib in advanced midgut NETs, primarily due to a lower-than-expected number of enrolled patients. While we cannot entirely rule out the efficacy of sunitinib, lanreotide alone may play a significant role. Trial registration: EudraCT: 2012-001098-94.