bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calcineurin Inhibitor and Nonsteroidal Anti‐inflammatory Drug Interaction: Implications of Changes in Renal Function Associated With Concurrent Use
Authors: Delzer Luke M. , Golightly Larry K. , Kiser Tyree H. , Biggins Scott W. , Lewis Victor J. , Kim Ike I. 
Published: May 2018

AbstractEvidence for a drug interaction between calcineurin inhibitors (CNIs) and nonsteroidal anti‐inflammatory drugs (NSAIDs) is meager, and the magnitude of risk for adverse renal effects associated with this interaction is unclear. To explicate these uncertainties, sequential measures of kidney function were evaluated in hospitalized adult solid organ or allogeneic hematopoietic stem cell transplant recipients who received maintenance CNI therapy and concurrent treatment with an oral or parenteral NSAID. A comparator group of closely matched transplant recipients on CNI therapy who did not receive NSAID treatment during hospitalization was similarly evaluated. Among inpatients on CNIs, treatment‐emergent acute kidney injury occurred in 5 of 41 (12.2%) patients exposed to concurrent NSAIDs and in 7 of 126 (5.6%) of matched patients who were not exposed to NSAIDs (relative risk ratio 2.20, 95% confidence interval 0.74 to 6.54). During hospitalization, an increase in serum creatinine above baseline occurred in 80.5% of patients on CNI therapy who were exposed to NSAIDs as compared with 56.3% of patients on CNIs who were not exposed (P = .001). NSAID administration was an independent predictor for a rapid increase in serum creatinine (P = .026). The event rate for worsened renal function was highest among patients exposed to parenteral ketorolac. Because the likelihood of developing treatment‐related worsening of renal function is increased with combined use of CNIs and NSAIDs, concurrent use of these medications is inadvisable. Patients and clinicians should be counseled accordingly.
An eco‐friendly molecular imprinting technique for the selective recognition and controlled release of bovine serum albumin
Authors: Sadanandan Sandeep 
Published: May 2018

AbstractBACKGROUNDSynthesis of molecular imprinted polymer (MIP) by conventional methods is a tedious process due to the necessity for toxic organic solvents, chemicals and thermal activation for the free radical generation of initiators. In this study, a new MIP is synthesized using only the action of biopolymer blend cross‐linking in the presence of BSA as a template.RESULTSThe characteristics of the MIP were investigated using Fourier‐transform infrared spectroscopy, SEM, X‐ray diffraction and zeta potential analyses. The effects of cross‐linking density in imprinting efficiency, and the influence of pH and ionic strength in the loading of BSA into MIP were investigated. The adsorption isotherms of BSA onto MIP and nonimprinted polymer (NIP) were determined by a Langmuir model and showed a maximum binding capacity of 95.73 mg g−1 for MIP and 76.08 mg g−1 for NIP.CONCLUSIONThe porous structure formed in the polymer blend of MIP enables easy access of proteins by diffusion as clearly shown in an SEM image. Compared with the NIP blends, the MIP blends demonstrated much higher adsorption capacity due to the presence of multiple hydrogen bonds and covalent bond interaction between the imprinted cavities and template proteins. The merits of this novel technique include elimination of a complex polymerization reaction, toxic volatile organic solvents and free radical initiators. Thus, this new way of strategy will be a promising trend for the future preparation of environmentally benign molecular imprinted polymer materials. © 2018 Society of Chemical Industry
Differential characteristics in drug‐induced autoimmune hepatitis
Authors: Martínez‐Casas Omar Yesid , Díaz‐Ramírez Gabriel Sebastián , Marín‐Zuluaga Juan Ignacio , Muñoz‐Maya Octavio , Santos Oscar , Donado‐Gómez Jorge Hernando , Restrepo‐Gutiérrez Juan Carlos 
Published: May 2018

Background and AimDrug‐induced autoimmune hepatitis (DIAIH) is an adverse effect associated with several drugs that usually occurs acutely, with variable latency, and it may potentially be mortal. There are a few reports and studies about DIAIH.MethodsThis was an analytical study of a retrospective cohort of patients, discriminated according to idiopathic or drug‐induced etiology, followed up for a 7‐year period until 31 December 2016.ResultsA total of 190 patients were selected for the analysis, 12 (6.3%) with DIAIH. The two main drugs related to DIAIH were nitrofurantoin, n = 8 (67%), and NSAID, n = 2 (17%), constituting 84% of the cases. There were no significant differences in seropositivity between AIH with DIAIH in antinuclear antibodies (ANA) and anti‐smooth muscle antibodies (ASMA) antibodies, with 82.6% versus 82.6% and 34% versus 16%, respectively. The fibrosis stages were similar, except for the F4 stage, in a greater proportion in AIH. None of the patients with DIAIH had cirrhosis or developed it during follow‐up, but it was present in 42.1% of the AIH cases at diagnosis (P = 0.003). Biochemical remission with management was higher in DIAIH but not significant (91.7% vs 80.9%, P = 0.35). The definitive interruption of immunosuppression was successfully performed in 25% of those with DIAIH without relapses but was only possible in 2.8% in AIH (P < 0.001) with 32 cases of relapses.ConclusionDIAIH constitutes a minor proportion of AIH. The clinical and histological characteristics may be similar; DIAIH patients have a greater chance of having treatment suspended with a low risk of relapse, progression to cirrhosis, or need for liver transplant.
Human interleukin‐10 delivered intrathecally by self‐complementary adeno‐associated virus 8 induces xenogeneic transgene immunity without clinical neurotoxicity in swine
Authors: Unger Mark D. , Pleticha Josef , Heilmann Lukas F. , Newman Laura K. , Maus Timothy P. , Beutler Andreas S. 
Published: May 2018

AbstractIntroductionIntrathecal interleukin (IL)‐10 delivered by plasmid or viral gene vectors has been proposed for clinical testing because it is effective for chronic pain in rodents, is a potential therapeutic for various human diseases, and was found to be nontoxic in dogs, when the human IL‐10 ortholog was tested. However, recent studies in swine testing porcine IL‐10 demonstrated fatal neurotoxicity. The present study aimed to deliver vector‐encoded human IL‐10 in swine, measure expression of the transgene in cerebrospinal fluid and monitor animals for signs of neurotoxicity.ResultsHuman IL‐10 levels peaked 2 weeks after vector administration followed by a rapid decline that occurred concomitant with the emergence of anti‐human IL‐10 antibodies in the cerebrospinal fluid and serum. Animals remained neurologically healthy throughout the study period.ConclusionsThe findings of the present study suggest that swine are not idiosyncratically sensitive to intrathecal IL‐10 because, recapitulating previous reports in dogs, they suffered no clinical neurotoxicity from the human ortholog. These results strongly infer that toxicity of intrathecal IL‐10 in large animal models was previously overlooked because of a species mismatch between transgene and host. The present study further suggests that swine were protected from interleukin‐10 by a humoral immune response against the xenogeneic cytokine. Future safety studies of IL‐10 or related therapeutics may require syngeneic large animal models.
Postoperative infections after dental implant placement: Variables associated with increased risk of failure
Authors: Camps‐Font Octavi , Martín‐Fatás Pablo , Clé‐Ovejero Adrià , Figueiredo Rui , Gay‐Escoda Cosme , Valmaseda‐Castellón Eduard 
Published: May 2018

AbstractBackgroundWound infections after dental implant placement are a rare finding that might lead to early implant failure. However, the available information on this topic is scarce.MethodsThis retrospective cohort study was conducted to determine factors that may increase the failure rate of dental implants that presented a postoperative infection during the osseointegration period. Postoperative infections were defined as the presence of pus or fistula in the surgical area, with pain or tenderness, swelling, redness, and heat or fever, before prosthetic loading. A bivariate and multivariate analysis of the data using Cox proportional‐hazards regression was performed to detect prognostic factors for implant failure in patients that suffer infections.ResultsThe patient‐based prevalence of postoperative infections after implant placement was 2.80% (95% confidence interval (95%CI): 2.04% to 3.83%). Thirty‐three out of 37 (89.19%) patients with infections had to be surgically retreated because of antibiotic failure and 65% of the infected implants were removed. The bivariate analysis showed a significant association between implant failure and the collar surface (HR: 3.12; 95% CI: 1.16 to 8.41; P = 0.014). Cox proportional‐hazards regression indicated that rough‐surfaced collars increased 2.35 times the likelihood of failure (95% CI: 0.87 to 6.37; P = 0.071).ConclusionsThe survival of implants placed in the maxilla, with smooth collar, and late‐onset of infection was higher than those placed in the mandible, with a rough collar and early onset of infection. In general, signs of infection after dental implant placement compromises the survival rate of the affected fixtures.
Construction of pH‐Responsive Supramolecular Assemblies Based on Dynamic Covalent Bonds for Tunable Drug Release
Authors: Sun Panpan , Lu Fei , Wu Aoli , Yin Yue , Shi Lijuan , Zheng Liqiang 
Published: May 2018

AbstractIn the present work, we propose a novel strategy for preparing supramolecular self‐assemblies for pH‐responsive drug delivery. In alkaline solutions, a novel supra‐amphiphile can be fabricated by a cationic surfactant dodecyl[2‐(4‐formylphenoxy)ethyl] dimethylammonium bromide (C12‐CHO) and a drug molecule (isonicotinic acid hydrazide) via a dynamic covalent bond. The constructed supra‐amphiphile can hierarchically self‐assemble into ordered micelles, which facilitates its use for drug delivery. Interestingly, the supra‐amphiphile can facilely disassemble under specific acidic conditions, which is convenient for controlled release of drugs. Thus, this ionic amphiphile‐drug system paves a way for realizing pH‐driven targeted drug release.
Comparison of sensory perception and verbal expression of Korean Kimchi stews between Chinese consumers and Korean trained panelists
Authors: Park Hye‐Won , Kim Young Choul , Jang Seong‐Ho , Hong Jae‐Hee 
Published: May 2018

AbstractBACKGROUNDSensory drivers of liking in foreign food markets are difficult to identify because the expression of perceived characteristics varies depending on cultural differences. We aimed to identify differences in the perception and expression of a Korean home meal replacement product (Kimchi stew) between 10 Korean trained panelists versus 50 eastern Chinese consumers (EC) and 54 northern Chinese consumers (NC) using descriptive analysis and rate‐all‐that‐apply (RATA) tests. Regional differences between the EC and NC groups were also investigated.RESULTSSensory representations of the six Kimchi stew samples were similar between the Korean trained and Chinese consumer panels. Use of simple sensory RATA terms was similar among the groups. However, EC, who have a daily diet with mild flavors, associated consumer terms with negative connotations, such as odd flavor and sharp, with burning sensation and seasoning, implying the influence of regional food cultures.CONCLUSIONRATA could elicit foreign consumers' sensory representations of an unfamiliar ethnic food that was comparable to that from descriptive analysis, assisting researchers in understanding target consumers' sensory perceptions in a more cost‐ and time‐effective manner. The inclusion of consumer terms in a RATA list and its correlation with descriptive analysis by a native descriptive panel can help with the understanding of foreign consumers' verbal expressions. © 2018 Society of Chemical Industry
Prediction of storm‐based nutrient loss incorporating the estimated runoff and soil loss at a slope scale on the Loess Plateau
Authors: Shi Wenhai , Huang Mingbin , Wu Lianhai 
Published: May 2018

AbstractSoil nutrient loss driven by soil erosion and runoff leads to land degradation, thereby decreasing soil productivity and crop yield. Nutrient loss modelling is an important tool for designing efficient soil and water conservation practices that alleviate land degradation. We proposed a framework to integrate newly developed models for sediment‐bound nutrient loss and runoff‐associated nutrient loss with the modified storm‐based Chinese soil loss equation model and modified Soil Conservation Service curve number model to predict particulate nutrient losses of nitrogen (N), carbon (C), and phosphorus (P) and soluble nutrient losses of P and nitrate. The data collected from the literature included 330 storm events with experimental plot measurements of runoff, sediment, and particulate and soluble nutrient losses conducted on slopes in Loess Plateau; and these data were used to calibrate and assess model performances. The accuracies of the model estimations were examined with the Nash–Sutcliffe efficiency (NSE). The proposed models with optimized parameters showed high NSE for particulate N (98.5%), C (98.9%), and P (99.8%) and soluble P (95.8%) and nitrate (85.4%) when compared with the literature‐reported measured losses. To test the models, independent literature data were compared with model‐estimated values. The comparison showed agreement between the estimated and observed data with NSEs of 74.4%, 63.7%, 86.3%, 63.6%, and 66.7% for particulate N, C, P, soluble P, and nitrate, respectively.
Evaluation of absorbable PLA nasal implants in an ovine model
Authors: Rippy Marian K. , Baron Scott , Rosenthal Mike , Senior Brent A. 
Published: May 2018

ABSTRACTObjectiveTo examine biocompatibility and absorption profile of a poly (L‐lactide‐co‐D,L‐lactide) 70:30 nasal implant.MethodsIn an ovine model, 66 rod‐shaped absorbable implants were placed in 11 nasal dorsa. The sheep were sacrificed at 1.5 (N = 3), 6 (N = 3), 12 (N = 3), 18 (N = 1), and 24 months (N = 1). The nasal dorsum was harvested from each animal. Gross and histopathological examinations were performed.ResultsThere were no postoperative complications, signs of infection, or tissue rejection throughout follow‐up time points. Upon sacrifice, no abnormalities were identified during gross pathological examinations. The histology of the implant sites at all time points showed the implants were fully encapsulated through 12 months. The inflammatory reaction to the implants was minimal to mild at 1.5, 6, and 12 months. At 18 months the implant material was in the mass loss phase, being actively absorbed. During this phase, the inflammatory reaction within the fibrous connective tissue capsule reached expected moderate levels. By 24 months, the inflammatory reaction had diminished in most implantation sites and complete absorption of the rod implants was noted at some sites with nodular bundles of mature collagenized fibrous tissue replacing the implant, devoid of an inflammatory infiltrate.ConclusionBiocompatibility of the poly (L‐lactide‐co‐D,L‐lactide) 70:30 material was demonstrated when used as a nasal implant in the nasal dorsum ovine model. Absorption of the implant occurred approximately 18 to 24 months postoperatively, and the implant site was replaced with collagenized fibrous tissue.Level of EvidenceNA.
Assessment of skin lesions produced by focused, tunable, mid‐infrared chalcogenide laser radiation
Authors: Evers Michael , Ha Linh , Casper Malte , Welford David , Kositratna Garuna , Birngruber Reginald , Manstein Dieter 
Published: May 2018

BackgroundTraditionally, fractional laser treatments are performed with focused laser sources operating at a fixed wavelength. Using a tunable laser in the mid‐infrared wavelength range, wavelength‐dependent absorption properties on the ablation process and thermal damage formation were assessed with the goal to obtain customizable tissue ablations to provide guidance in finding optimized laser exposure parameters for clinical applications.MethodsLaser tissue experiments were carried out on full thickness ex vivo human abdominal skin using a mid‐infrared tunable chromium‐doped zinc selenide/sulfide chalcogenide laser. The laser has two independent channels: a continuous wave (CW) output channel which covers a spectrum ranging from 2.4 μm to 3.0 μm with up to 9.2 W output power, and a pulsed output channel which ranges from 2.35 μm to 2.95 μm. The maximum pulse energy of the pulsed channel goes up to 2.8 mJ at 100 Hz to 1,000 Hz repetition rate with wavelength‐dependent pulse durations of 4–7 ns.ResultsTotal ablation depth, ablation efficiency, and coagulation zone thickness were highly correlated to wavelength, pulse width, and pulse energy. Using the same total radiant exposure at 2.85 μm wavelength resulted in 10‐times smaller coagulation zones and 5‐times deeper ablation craters for one hundred 6 ns pulses compared to one 100 ms pulse. For a fixed pulse duration of 6 ns and a total radiant exposure of 2.25 kJ/cm2 the ablation depth increased with longer wavelengths.ConclusionThe tunable laser system provides a useful research tool to investigate specific laser parameters such as wavelength on lesion shape, ablation depth and thermal tissue damage. It also allows for customization of the characteristics of laser lesions and therefore facilitates the selection of suitable laser parameters for optimized fractional laser treatments. Lasers Surg. Med. 50:961–972, 2018.© 2018 Wiley Periodicals, Inc.
Cerebral edema induced by laser interstitial thermal therapy and radiotherapy in close succession in patients with brain tumor
Authors: Maraka Stefania , Asmaro Karam , Walbert Tobias , Lee Ian 
Published: May 2018

ObjectiveLaser interstitial thermal therapy (LITT) is an image‐guided technique that uses high temperature to ablate pathological tissue. Brain tumor patients undergoing LITT may also undergo radiation therapy (RT) either before or after LITT. Both procedures have been reported to increase cerebral edema and thereby the two treatments in close succession may worsen existing edema that can be difficult to control. The purpose of our study was to determine the frequency of increased and/or symptomatic cerebral edema after combined LITT and RT, the radiographic and clinical signs of this cerebral edema, and the treatment required.Materials and MethodsThis is a single center, retrospective study of patients who underwent LITT and RT less than 60 days apart. Brain Magnetic Resonance Imaging (MRI) and clinical information were reviewed at three time points (pre‐treatment, post‐LITT, and post‐RT).ResultsThe study cohort comprised eight patients: six with glioblastoma, one with anaplastic astrocytoma, and one with metastasis. Pre‐treatment MRI showed cerebral edema in seven patients. Post‐LITT MRI showed worsening cerebral edema in three patients, of which one was symptomatic. Post‐RT MRI showed worsening cerebral edema in one patient. One patient who received RT before LITT had asymptomatic cerebral edema post‐RT that improved post‐LITT. Three patients required prolonged steroid therapy (>65 days), while two patients required bevacizumab for steroid‐refractory edema.ConclusionsLITT and RT treatment in close succession can induce cerebral edema, which can usually be managed successfully with steroids, although the treatment period may be prolonged. A minority of patients may require more aggressive treatment, such as bevacizumab. Lasers Surg. Med. 50:917–923, 2018. © 2018 Wiley Periodicals, Inc.
Topological Insight into Superabsorbent Hydrogel Network Structures: a 1H Double‐Quantum NMR Study
Authors: Guo Xiaoai , Theissen Solveig , Claussen Jan , Hildebrand Viet , Kamphus Juliane , Wilhelm Manfred , Luy Burkhard , Guthausen Gisela 
Published: May 2018

AbstractSuperabsorbent polymer (SAP) hydrogels have pronounced water‐absorbing and water‐storing capacities, which are essential for numerous potential applications. It remains a challenge to better understand the network topology because of their amorphous and anisotropic structures. Synthesis parameters such as monomer concentration, degree of neutralization and crosslinking, and surface crosslinking are varied to correlate structural changes in the network with low‐field proton double‐quantum (1H DQ) NMR results. 1H DQ‐NMR data are processed by a reliable, user‐independent analysis approach to determine the fractions of network defects, of mobile sol components, and of network chains as well as the residual dipolar coupling distribution in SAPs. In addition, results obtained by applying different distributions to describe the DQ buildup curves are quantified and compared. The correlation between topological and synthesis parameters as well as the impact of temperature, swelling, and solvent of SAP on DQ signals is investigated and discussed.
New characterizations for differences of Volterra‐type operators from α‐weighted‐type space to β‐Bloch–Orlicz space
Authors: Liang Yu‐Xia , Chen Cui 
Published: May 2018

AbstractFirstly, we presented three equivalent characterizations for the boundedness of the difference of general Volterra‐type operators from α‐weighted‐type space to β‐Bloch–Orlicz space. Especially, the descriptions in terms of the n‐th power of the induced analytic self‐maps were described. And then we estimated their essential norms, which can provide new compactness criteria and be seen as generalizations of classical results. Finally, we completed this paper with similar results on the differences of other three integral‐type operators, which extend and strengthen several existing results in the literature.
Susceptibility to antibiotics in isolates of Lactobacillus plantarum RAPD‐type Lp299v, harvested from antibiotic treated, critically ill patients after administration of probiotics
Authors: Klarin Bengt , Larsson Anders , Molin Göran , Jeppsson Bengt 
Published: May 2018

AbstractRecultured Lactobacillus plantarum 299v‐like strains were tested regarding antibiotic susceptibility, and no decrease was detected. Antibiotics are frequently used to treat patients in intensive care units (ICUs) and are associated with a significant risk of selection of resistant bacterial strains. In particular, it is possible that genetic transfer of antibiotic resistance to the resident gastrointestinal flora, as well as to administered probiotics, may be increased in the ICU setting. The aim of the present investigation was to detect possible changes in antimicrobial susceptibility in reisolates of the probiotic strain Lactobacillus plantarum 299v (Lp299v) given to antibiotic treated, critically ill patients. Lp299v‐like strains were identified in cultures of biopsies and fecal samples from 32 patients given the probiotic strain enterally in two previous ICU studies. The patients received a variety of antibiotics. Isolates with the same genomic RAPD profile (RAPD‐type) as Lp299v were obtained to enable monitoring of antibiotic susceptibility by E‐tests. Forty‐two isolates, collected throughout the course of illness, were tested against 22 different antibiotics. No obvious decrease in susceptibility was found for 21 of the tested antibiotics. There was a tendency toward decreased susceptibility to ampicillin. The stable antibiotic susceptibility profiles of the Lp299v‐like isolates studied here suggests this probiotic is less likely to acquire resistance when administered to critically ill patients treated with broad‐spectrum antibiotics.