bluuebunny/crossref_metadata_2025_split huggingface dataset:
On-Chip Curing by Microwave for Long Term Usage of Electronic Devices in Harsh Environments
Authors: Park Jun-Young , Kim Weon-Guk , Bae Hagyoul , Jin Ik Kyeong , Kim Da-Jin , Im Hwon , Tcho Il-Woong , Choi Yang-Kyu 
Published: October 2018

AbstractMicrowave-induced thermal curing is demonstrated to improve the reliability and to prolong the lifetime of chips containing nanoscale electron devices. A film containing graphite powder with high microwave absorbing efficiency was fabricated at low cost. The film is flexible, bendable, foldable, and attachable to a chip. A commercial off-the-shelf chip and a representative 3-dimensional (3D) metal-oxide-semiconductor field-effect transistor (MOSFET), known as FinFET, were utilized to verify the curing behaviors of the microwave-induced heat treatment. The heat effectively cured not only total ionizing dose (TID) damage from the external environment, but also internal electrical stress such as hot-carrier injection (HCI), which are representative sources of damages in MOSFET insulators. Then, the characteristics of the pre- and post-curing electron devices are investigated using electrical measurements and numerical simulations.
Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents
Authors: Tsukiashi Asami , Min Kil Sik , Kitayama Hikaru , Terasawa Hiroaki , Yoshinaga Sosuke , Takeda Mitsuhiro , Lindoy Leonard F. , Hayami Shinya 
Published: October 2018

AbstractWater soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)3-3×(NH2trz)3×](BF4)2 (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280–330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.
Increasing the distance between two monomers of topoisomerase IIβ under the action of antitumor agent 4β-sulfur-(benzimidazole) 4′-demethylepipodophyllotoxin
Authors: Sun Lin-Yang , Zhu Li-Wen , Tang Ya-Jie 
Published: October 2018

AbstractTopoisomerases II (Top2s) are a group of essential enzymes involved in replication, transcription, chromosome condensation, and segregation via altering DNA topology. The mechanism of the Top2s poisons such as etoposide (VP-16) was reported as stabilizing the Top2-DNA complex and engendering permanent DNA breakage. As the structurally similar compound of VP-16, a novel 4β-sulfur-substituted 4′-demethylepipodophyllotoxin (DMEP) derivative (compound C-Bi) with superior antitumor activity was developed in our previous study. To understand the structural basis of the compound action, the crystal structure (2.54 Å) of human Top2 β-isoform (hTop2β) cleavage complexes stabilized by compound C-Bi was determined. However, compound C-Bi was not visible in the crystal structure. Through the comparison of the structures of hTop2β-DNA-etoposide ternary complex and hTop2β-DNA binary complex, it could be observed that the distance between drug-binding sites Arg503 of the two monomers was 26.62 Å in hTop2β-DNA-etoposide ternary complex and 34.54 Å in hTop2β-DNA binary complex, respectively. Significant twist were observed in the DNA chains of binary complex. It suggested that compound C-Bi played antitumor roles through increasing spacing of hTop2β monomers. The changes in hTop2β structure further caused double changes in the torsional direction and migration distance of the DNA chains, resulting in impeding religation of DNA.
Metallo-Curcumin-Conjugated DNA Complexes Induces Preferential Prostate Cancer Cells Cytotoxicity and Pause Growth of Bacterial Cells
Authors: Vellampatti Srivithya , Chandrasekaran Gopalakrishnan , Mitta Sekhar Babu , Lakshmanan Vinoth-Kumar , Park Sung Ha 
Published: October 2018

AbstractDNA nanotechnology can be used to create intricate DNA structures due to the ability to direct the molecular assembly of nanostructures through a bottom-up approach. Here, we propose nanocarriers composed of both synthetic and natural DNA for drug delivery. The topological, optical characteristics, and interaction studies of Cu2+/Ni2+/Zn2+-curcumin-conjugated DNA complexes were studied using atomic force microscopy (AFM), UV-vis spectroscopy, Fourier transform infrared and mass spectroscopy. The maximum release of metallo-curcumin conjugates from the DNA complexes, triggered by switching the pH, was found in an acidic medium. The bacterial growth curves of E. coli and B. subtilis displayed a prolonged lag phase when tested with the metallo-curcumin-conjugated DNA complexes. We also tested the in vitro cytotoxicity of the metallo-curcumin-conjugated DNA complexes to prostate cancer cells using an MTS assay, which indicated potent growth inhibition of the cells. Finally, we studied the cellular uptake of the complexes, revealing that DNA complexes with Cu2+/Ni2+-curcumin exhibited brighter fluorescence than those with Zn2+-curcumin.
Gaseous flow through heterogeneous, partially connected networks of pipes
Authors: Bernabé Yves 
Published: October 2018

AbstractSimulations of flow of an ideal gas through heterogeneous simple cubic pipe networks with different pipe radius distributions and variable bond coordination numbers were performed. Networks with monomodal and bimodal radius distributions were constructed. A very wide range of Knudsen numbers was achieved. Flow simulations of purely viscous gases and incompressible liquids were also carried out for comparison. The permeability to gas in the purely viscous regime was larger than the permeability to an incompressible liquid. Based on a variety of computational tests, this result was likely not a numerical artifact. The simulated macroscopic flow behavior differed from the underlying single pipe model, depending on the radius distribution, network connectivity and magnitude of the externally applied pressure gradient, and was compatible with the Klinkenberg analysis only when the maximum Knudsen number used in each simulation was lower than 1. In this condition, the Klinkenberg coefficient was nearly proportional to the inverse of the network hydraulic radius while the effect of the radius distribution was weak and that of the network connectivity essentially negligible. The bimodal simulations displayed a typical percolation behavior, with the Klinkenberg coefficient remaining constant as long as the large pipe population was connected.
Identification of pharmacological inhibitors of conventional protein secretion
Authors: Zhao Liwei , Liu Peng , Boncompain Gaelle , Loos Friedemann , Lachkar Sylvie , Bezu Lucillia , Chen Guo , Zhou Heng , Perez Franck , Kepp Oliver , Kroemer Guido 
Published: October 2018

AbstractThe retention using selective hooks (RUSH) system allows to withhold a fluorescent biosensor such as green fluorescent protein (GFP) fused to a streptavidin-binding peptide (SBP) by an excess of streptavidin molecules that are addressed to different subcellular localizations. Addition of biotin competitively disrupts this interaction, liberating the biosensor from its hook. We constructed a human cell line co-expressing soluble secretory-SBP-GFP (ss-SBP-GFP) and streptavidin within the endoplasmic reticulum (ER) lumen and then used this system to screen a compound library for inhibitors of the biotin-induced release of ss-SBP-GFP via the conventional Golgi-dependent protein secretion pathway into the culture supernatant. We identified and validated a series of molecularly unrelated drugs including antianginal, antidepressant, anthelmintic, antipsychotic, antiprotozoal and immunosuppressive agents that inhibit protein secretion. These compounds vary in their capacity to suppress protein synthesis and to compromise ER morphology and Golgi integrity, as well as in the degree of reversibility of such effects. In sum, we demonstrate the feasibility and utility of a novel RUSH-based phenotypic screening assay.
The Duality of the MAPK Signaling Pathway in the Control of Metabolic Processes and Cellulase Production in Trichoderma reesei
Authors: de Paula Renato Graciano , Antoniêto Amanda Cristina Campos , Carraro Cláudia Batista , Lopes Douglas Christian Borges , Persinoti Gabriela Felix , Peres Nalu Teixeira Aguiar , Martinez-Rossi Nilce Maria , Silva-Rocha Rafael , Silva Roberto Nascimento 
Published: October 2018

AbstractIn this study, through global transcriptional analysis by RNA-Sequencing, we identified the main changes in gene expression that occurred in two functional mutants of the MAPK genes tmk1 and tmk2 in Trichoderma reesei during sugarcane bagasse degradation. We found that the proteins encoded by these genes regulated independent processes, sometimes in a cross-talk manner, to modulate gene expression in T. reesei. In the Δtmk2 strain, growth in sugarcane bagasse modulated the expression of genes involved in carbohydrate metabolism, cell growth and development, and G-protein-coupled receptor-mediated cell signaling. On the other hand, deletion of tmk1 led to decreased expression of the major genes for cellulases and xylanases. Furthermore, TMK1 found to be involved in the regulation of the expression of major facilitator superfamily transporters. Our results revealed that the MAPK signaling pathway in T. reesei regulates many important processes that allow the fungus to recognize, transport, and metabolize different carbon sources during plant cell wall degradation.
Flow cytometry analysis of adrenoceptors expression in human adipose-derived mesenchymal stem/stromal cells
Authors: Tyurin-Kuzmin Pyotr A. , Dyikanov Daniyar T. , Fadeeva Julia I. , Sysoeva Veronika Yu. , Kalinina Natalia I. 
Published: October 2018

AbstractMesenchymal stem/stromal cells (MSCs) were identified in most tissues of an adult organism. MSCs mediate physiological renewal, as well as regulation of tissue homeostasis, reparation and regeneration. Functions of MSCs are regulated by endocrine and neuronal signals, and noradrenaline is one of the most important MSC regulators. We provided flow cytometry analysis of expression of adrenergic receptors on the surface of human MSCs isolated from ten different donors. We have found that the expression profile of adrenergic receptors in MSCs vary significantly between donors. We also showed that alpha1A-adrenoceptor expression is upregulated under the action of noradrenaline. We share our flow cytometry raw data, as well as processing of these data on a flow cytometry repository for freely downloading.
Transcriptomes of cochlear inner and outer hair cells from adult mice
Authors: Li Yi , Liu Huizhan , Giffen Kimberlee P. , Chen Lei , Beisel Kirk W. , He David Z. Z. 
Published: October 2018

AbstractInner hair cells (IHCs) and outer hair cells (OHCs) are the two anatomically and functionally distinct types of mechanosensitive receptor cells in the mammalian cochlea. The molecular mechanisms defining their morphological and functional specializations are largely unclear. As a first step to uncover the underlying mechanisms, we examined the transcriptomes of IHCs and OHCs isolated from adult CBA/J mouse cochleae. One thousand IHCs and OHCs were separately collected using the suction pipette technique. RNA sequencing of IHCs and OHCs was performed and their transcriptomes were analyzed. The results were validated by comparing some IHC and OHC preferentially expressed genes between present study and published microarray-based data as well as by real-time qPCR. Antibody-based immunocytochemistry was used to validate preferential expression of SLC7A14 and DNM3 in IHCs and OHCs. These data are expected to serve as a highly valuable resource for unraveling the molecular mechanisms underlying different biological properties of IHCs and OHCs as well as to provide a road map for future characterization of genes expressed in IHCs and OHCs.
Free-electron laser data for multiple-particle fluctuation scattering analysis
Authors: Pande Kanupriya , Donatelli Jeffrey J. , Malmerberg Erik , Foucar Lutz , Poon Billy K. , Sutter Markus , Botha Sabine , Basu Shibom , Bruce Doak R. , Dörner Katerina , Epp Sascha W. , Englert Lars , Fromme Raimund , Hartmann Elisabeth , Hartmann Robert , Hauser Guenter , Hattne Johan , Hosseinizadeh Ahmad , Kassemeyer Stephan , Lomb Lukas , Montero Sebastian F. Carron , Menzel Andreas , Rolles Daniel , Rudenko Artem , Seibert Marvin M. , Sierra Raymond George , Schwander Peter , Ourmazd Abbas , Fromme Petra , Sauter Nicholas K. , Bogan Michael , Bozek John , Bostedt Christoph , Schlichting Ilme , Kerfeld Cheryl A. , Zwart Petrus H. 
Published: October 2018

AbstractFluctuation X-ray scattering (FXS) is an emerging experimental technique in which solution scattering data are collected using X-ray exposures below rotational diffusion times, resulting in angularly anisotropic X-ray snapshots that provide several orders of magnitude more information than traditional solution scattering data. Such experiments can be performed using the ultrashort X-ray pulses provided by a free-electron laser source, allowing one to collect a large number of diffraction patterns in a relatively short time. Here, we describe a test data set for FXS, obtained at the Linac Coherent Light Source, consisting of close to 100 000 multi-particle diffraction patterns originating from approximately 50 to 200 Paramecium Bursaria Chlorella virus particles per snapshot. In addition to the raw data, a selection of high-quality pre-processed diffraction patterns and a reference SAXS profile are provided.
Regulation des Knochenstoffwechsels durch den Wnt-Signalweg
Authors: Houschyar K.S. , Tapking C. , Duscher D. , Harati K. , Wallner C. , Wagner J.M. , Maan Z.N. , Rein S. , Chelliah M.P. , Reumuth G. , Grieb G. , Siemers F. , Lehnhardt M. , Behr B. 
Published: October 2018

ZusammenfassungDie Entwicklung und Homöostase von multizellulären Organismen hängt von einem komplexen zellulären Zusammenspiel zwischen Proliferation, Migration,
Differenzierung, Adhäsion und Zelltod ab. Die Wnt-Signalwege spielen für die Koordination dieser verschiedenen zellulären Antworten eine wichtige Rolle,
insbesondere als regulatorischer Weg bei der osteogenen Differenzierung von mesenchymalen Stammzellen. Der Wnt-Signalweg ist ein attraktives therapeutisches
Ziel mit dem Potenzial, Stammzellen, die für die Regeneration des Skelettgewebes verantwortlich sind, direkt zu modulieren. Neuere Untersuchungen zeigen, dass
Wnt-Liganden in der Lage sind, das Knochenwachstum zu fördern, was nahe legt, dass Wnt-Faktoren zur Stimulation der Knochenheilung bei osteogenen Störungen
verwendet werden könnten.
Inpatient Rehabilitation for Children and Adolescents With Diabetes
in Germany Between 2006 and 2013
Authors: Auzanneau Marie , Bohn Barbara , Schiel Ralf , Stachow Rainer , Koch Sibylle , Hermann Thomas , Holl Reinhard W. 
Published: October 2018

Abstract
Introduction In Germany, inpatient rehabilitation is a
well-established additive option in the therapeutic concept for children and
adolescents with diabetes. However, its contribution in pediatric diabetes
care is not known exactly. Our objective was to analyze inpatient
rehabilitation in pediatric diabetes over eight years in Germany.
Methods We requested secondary data from the German Statutory Pension
Insurance Scheme to evaluate all completed inpatient rehabilitations for
children and adolescents with diabetes (ICD-code E10-14) reimbursed by this
institution between 2006 and 2013. For each type of diabetes, we analyzed
the distribution of admissions by year, age-group, sex, nationality, and
other documented diagnoses. All analyses were conducted via remote computing
with IBM SPSS Version 24.
Results Between 2006 and 2013, 5,403 admissions to inpatient
rehabilitation for 4,746 children and adolescents with diabetes were
documented. For type 1 diabetes (T1D; 88.5% of admissions), the
number of yearly admissions increased from 458 in 2006 to 688 in 2013
(p=0.013), especially for age-group>5-10. The increase for
type 2 diabetes (T2D) was not significant. Admissions were more frequent for
girls (53.6%, p≤0.001), age>10-15 years
(42.8%, p=0.001), and German nationality (98.5%).
Obesity (T1D: 11.1%; T2D: 87.9%) and mental disorders (T1D:
11.6%; T2D: 27.4%) were the most frequent documented
diagnoses in addition to diabetes.
Conclusion This study provides a comprehensive overview of inpatient
rehabilitation for children and adolescents with diabetes over many years in
Germany. Until 2013, inpatient rehabilitation remained important in
pediatric diabetes care, especially for children with mental disorders or
obesity.
Stereoselective Synthesis of Tetrahydrofuran Lignans
Authors: Soorukram Darunee , Pohmakotr Manat , Kuhakarn Chutima , Reutrakul Vichai 
Published: October 2018

This short review aims to summarize the reports on stereoselective synthesis of naturally occurring tetrahydrofuran lignans published during the period of 2006 to 2018. The stereoselective construction of non-natural tetrahydrofuran frameworks is not included in this review.1	Introduction2	Stereoselective Synthesis of 2,5-Diaryltetrahydrofuran (CL5-a)2.1	Synthesis of CL5-a via Friedel–Crafts Arylation or Nucleophilic Addition/Reduction of γ-Butyrolactones2.2	Synthesis of CL5-a via Intramolecular Cyclization of 1,4-Diaryl­butanediols2.3	Synthesis of CL5-a via Diastereoselective Hydrogenation of Furan Derivatives2.4	Synthesis of CL5-a via Cycloaddition Reaction of Substituted Cyclopropane­ Derivatives3	Stereoselective Synthesis of 2-Aryl-4-benzyltetrahydrofuran (CL5-b)4	Stereoselective Synthesis of 3,4-Dibenzyltetrahydrofuran (CL5-c)5	Conclusions
Catheter-Based Computed Tomography Angiography in Anterolateral Thigh Perforator Mapping of Chinese Patients
Authors: Wang Zhongjie , He Jiqiang , Qing Liming , Zhou Zhengbing , Zhang Youming , Zhu Zhiming , Zhou Chunhui , Xie Hui , Li Xuejun , Zee Chishing , Chen Bihong , Yi Xiaoping 
Published: October 2018

Background During reconstructive surgery, anterolateral thigh (ALT) flap harvest is challenging due to variation and uncertainty in perforator distribution. We performed a pilot study to identify the predictive value of catheter-based computed tomography angiography (C-CTA) and traditional CTA (T-CTA) in ALT perforator mapping for patients whose ALT perforators were difficult to identify.
Methods Thirty-four consecutive T-CTA/C-CTA-mapped ALT flaps were evaluated for extremity reconstruction. The perforator location, origin, and course were compared between T-CTA/C-CTA imaging and intraoperative findings. The mapping efficiency of T-CTA and C-CTA was compared thoroughly.
Results Among the 34 ALT thigh flaps, 117 (36) of the 130 perforators identified intraoperatively were visible on C-CTA (T-CTA) in a subgroup of Chinese limb trauma patients with limited activity. C-CTA showed a satisfactory efficiency in perforator mapping, which was much better than the efficiency of T-CTA. C-CTA also showed a much better sensitivity (90.00 vs. 27.69%), specificity (94.74 vs. 66.67%), and accuracy (91.07 vs. 36.69%), and a much lower false-positive (1.68 vs. 26.53%), and false-negative rate (10.00 vs. 72.31%). Moreover, C-CTA could accurately predict the origin and septocutaneous or intramuscular course in all identified perforators. All flaps were elevated successfully and survived.
Conclusion C-CTA outperforms T-CTA in the preoperative perforator mapping of ALT flaps in a subgroup of Chinese limb trauma patients. C-CTA should be the method of choice for perforator mapping in patients whose ALT flaps are intended for extremity reconstruction.
Global Health – Zukunftsfeld der Physiotherapie
Authors: Barth Cornelia A. 
Published: October 2018

ZusammenfassungCornelia A. Barth ist Physiotherapeutin mit jahrelanger internationaler Erfahrung im Bereich der humanitären Hilfe und Entwicklungszusammenarbeit. Die Situation
von Menschen mit Behinderung sowie der Mangel an Ressourcen in vielen Teilen der Welt veranlassten sie, sich mit globalen Konzepten auseinanderzusetzen. Sie
sagt: „Es wäre wünschenswert, wenn künftig der Global-Health-Gedanke vermehrt Einzug in Physiotherapie-Curricula, professionelle Diskussionen und
Forschungsprojekte fände.“
Language style in the negotiation of class identity in translated contemporary Spanish fiction
Authors: Espunya Anna , Pavić Pintarić Anita 
Published: October 2018

AbstractIn the early novels of the Carvalho detective series by Manuel Vázquez Montalbán, set in the years of Spain’s transition to democracy, the negotiation of identities and political stance are paramount characterization resources. Given the role of speech in the construction of identity, translations may vary in the readings they afford beyond the detective aspects. We apply the sociolinguistic concepts of identity work and language style (albeit mediated by fictive orality), and the discourse analysis tools of Appraisal Theory, to analyse two working-class characters inLos mares del sur(1979) and in its English (1986) and Croatian (2007) translations.In Spanish the language style of both characters reflects class allegiance, involvement and tenacity, intense feelings, a direct interpersonal approach and a rejection of altercasting. Their vocabulary and quotations from external sources index their ideology. The English translation is the least aware of identity work through language style and interaction. The characters’ standardized speech shows less involvement, tenacity and intensity. The Croatian translation follows the source text literally; involvement is maintained within a fictive colloquial spoken variety. Both translations maintain directness and a contractive dialogic style, and both make references to class and ideology more explicit.
China’s language services as an emerging industry
Authors: Luo Huifang , Meng Yongye , Lei Yalin 
Published: October 2018

Abstract
Languages play an essential role in China’s drive for modernization and in its interactions with the rest of the world. Discussions in this paper are designed to offer an overview of China’s language services, which have grown into a sizable industry with more than 70,000 businesses. In addition to its growth in size, the language services industry has also been a leader in introducing CAT technology in translation and adopting advanced technologies such as cloud computing, artificial intelligence, etc. Language service providers (LSPs) have also worked with institutions of higher learning in various forms of collaboration to provide internship opportunities to students of translation and other forms of support to universities. In order to promote the healthy development of the industry, the Translators Association of China (TAC) has done a huge amount of work in organizing industry efforts to develop guidelines for different kinds of language services, and help the industry to exercise self-regulation. This paper also discusses the challenges that the industry faces today and offers recommendations to the industry as it moves forward.
Exploring the effects of instruction on L2 French learner pronunciation, accentedness, comprehensibility, and
fluency
Authors: Inceoglu Solène 
Published: October 2018

Abstract
This study investigates the effects of a 16-week course on the development of second language French pronunciation. The course
targeted segmental and suprasegmental features and fluency development, and was administered entirely online. Pre- and post-test
tasks (i.e., picture narration, reading-aloud, and conversation simulation) were used to analyze learners’ pronunciation
development in terms of segmental errors, connected speech (use of liaisons and enchaînements), and fluency
(including pauses and mean length of run). Participants’ accentedness, comprehensibility, and fluency were also judged by five
native listeners. Findings revealed a significant decrease in segmental errors and unfilled pause frequency in all the tasks, and
improvement in fluency in the reading and conversation tasks. Results also showed a positive trend but no significant improvement
in the use of liaisons and enchaînements. There was, however, no significant improvement in the measures of
listeners’ ratings. The results are discussed in light of previous research on pronunciation instruction.