bluuebunny/crossref_metadata_2025_split huggingface dataset:
Terahertz Sensing Based on Metasurfaces
Authors: Beruete Miguel , Jáuregui‐López Irati 
Published: July 2019

AbstractThe terahertz (THz) band has very attractive characteristics for sensing and biosensing applications, due to some interesting features such as being a non‐ionizing radiation, very sensitive to weak interactions, thus, complementing typical spectroscopy systems in the infrared. However, a fundamental drawback is its relatively long wavelength (10–1000 µm) which makes it blind to small features, hindering seriously both thin‐film and biological sensing. Recently, new ways to overcome this limitation have become possible thanks to the advent of metasurfaces. These artificial structures are planar screens usually made of periodic metallic resonators and whose electromagnetic response can be controlled at will by design. This design freedom allows metasurfaces to surpass the restrictions of classical THz spectroscopy, by creating fine details comparable to the size of the thin films or microorganisms under test. The strong field concentration near these small metasurface details at resonance makes them highly sensitive to tiny variations in the nearby environment, allowing for an enhanced detection more accurate than classical THz spectroscopy. The main advances in THz metasurface sensors from a historical as well as application‐oriented perspective are summarized. The focus is put mainly on thin‐film and biological sensors, with an aim to cover the most recent advances in the topic.
Fluorescence Detection and Dissociation of Amyloid‐β Species for the Treatment of Alzheimer's Disease
Authors: Lv Guanglei , Shen Yang , Zheng Wubin , Yang Jiajia , Li Chunxia , Lin Jun 
Published: July 2019

AbstractAlzheimer's disease (AD) is one of the most prevalent forms of neurodegenerative disease. It is well established that the β‐amyloid peptide (Aβ) species existing in several forms, such as soluble monomers, oligomers, and insoluble aggregates, play an essential role in the pathophysiology of AD. Therefore, much effort has been made to specifically detect Aβ species and to inhibit Aβ aggregation for the treatment of AD. In this review, an overview of recent advances in detecting different Aβ forms mainly containing Aβ aggregates, Aβ oligomers, and Aβ protofibrils is provided. In addition, photodynamic therapy (PDT) and photothermal therapy (PTT) are considered to be promising modalities for the treatment of AD because of the minimal invasiveness and high spatial selectivity. Herein, the strategies of inhibiting Aβ aggregation and dissociating Aβ aggregates using PDT, PTT, and Aβ inhibitors for the treatment of AD are summarized.
Metal–Organic Frameworks in Modern Physics: Highlights and Perspectives
Authors: Mezenov Yuri A. , Krasilin Andrei A. , Dzyuba Vladimir P. , Nominé Alexandre , Milichko Valentin A. 
Published: July 2019

AbstractOwing to the synergistic combination of a hybrid organic–inorganic nature and a chemically active porous structure, metal–organic frameworks have emerged as a new class of crystalline materials. The current trend in the chemical industry is to utilize such crystals as flexible hosting elements for applications as diverse as gas and energy storage, filtration, catalysis, and sensing. From the physical point of view, metal–organic frameworks are considered molecular crystals with hierarchical structures providing the structure‐related physical properties crucial for future applications of energy transfer, data processing and storage, high‐energy physics, and light manipulation. Here, the perspectives of metal–organic frameworks as a new family of functional materials in modern physics are discussed: from porous metals and superconductors, topological insulators, and classical and quantum memory elements, to optical superstructures, materials for particle physics, and even molecular scale mechanical metamaterials. Based on complementary properties of crystallinity, softness, organic–inorganic nature, and complex hierarchy, a description of how such artificial materials have extended their impact on applied physics to become the mainstream in material science is offered.
MAP1B related syndrome: Case presentation and review of literature
Authors: Julca Diana M. , Diaz Jullianne , Berger Seth , Leon Eyby 
Published: July 2019

AbstractThe microtubule‐associated protein 1B (MAP1B) gene serves an important role in axonal growth and brain development. Its expression is known to be elevated in regions that retain high brain plasticity and is regulated by the fragile X mental retardation protein. MAP1B mutations have recently been associated with a phenotype including periventricular nodular heterotopia (PVNH), intellectual disability (ID), seizures, and dysmorphic features. We describe a child presenting with global developmental delays, ID, microcephaly, short stature, seizures, dysmorphic features, and prenatal alcohol exposure with a de novo nonsense MAP1B mutation (c.2035G>T, p.Glu679X) detected on whole exome sequencing (WES). His brain MRI showed PVNH and dysgenesis of the corpus callosum. While significant prenatal alcohol exposure could have modified his phenotype, we believe that this patient presents with features that cannot be explained by fetal alcohol exposure alone. This is the first case report that describes dysmorphic features associated with MAP1B mutations in detail along with supporting pictures and review of previous reported phenotypes. This case not only highlights the value of WES as a screening tool for unrecognized syndromes, but also supports the need for a better description of the phenotype associated with newly detected genetic syndromes by molecular screening.
The service system challenges of work with juvenile justice involved young people in the Hunter Region, Australia
Authors: Blakemore Tamara , Agllias Kylie , Howard Amanda , McCarthy Shaun 
Published: July 2019

AbstractCurrent policies suggest that collaborative approaches are core to working effectively with juvenile justice involved young people. However, there is little research examining the workings of multi‐agency and collaborative endeavours in this field, or the experiences of the human service workers facilitating these connections. This paper reports on qualitative research that resulted from the Juvenile Justice and Education Equity in the Hunter Region project. Thirty‐eight human service workers were interviewed about their perceptions of the workings, strengths and challenges of the service system that supports young people who come into contact with the Children's Court in the Lower and Upper Hunter regions of New South Wales. Data analysis revealed three key themes related to (1) service gaps, cycles and maelstrom; (2) pursuing authentic service engagement; and (3) insider–outsider dynamics in service provision. Findings are discussed in relation to emerging practice and research agendas.
Development and validation of a nomogram for prognosis of sinonasal squamous cell carcinoma
Authors: Quan Huatao , Yan Li , Zhang Haiyan , Zou Lifen , Yuan Wei , Wang Shengzi 
Published: July 2019

BackgroundSinonasal squamous cell carcinoma (SNSCC) is a rare malignancy with varied outcomes. The aim of this study was to develop a nomogram for predicting survival of patients with SNSCC.MethodsFrom the Surveillance, Epidemiology, and End Results database, we identified 1766 patients diagnosed with SNSCC between 2004 and 2015. Patients were randomly separated into a training set and a validation set in 4:1 ratio. An external validation was also performed by a set of 74 SNSCC patients who had been treated in our department. We used the training set to build a nomogram based on stratified multivariable Cox proportional hazard models for predicting overall survival. The predictive accuracy and discriminative ability of the nomogram were determined by concordance index and calibration curve.ResultsBased on 1412 cases of the training cohort, our Cox regression analysis revealed that age, marital status, primary site, differentiation, T stage, N classification, M stage, and treatment modalities were associated with overall survival. A nomogram was established based on the results of multivariate analysis. The C‐index values of the nomogram for predicting survival were superior to those of the tumor‐node‐metastasis staging system (0.745 vs 0.679 in the training cohort, 0.752 vs 0.656 in the validation set, and 0.678 vs 0.596 in the external validation set). The calibration plots demonstrated good consistency between the predicted and observed results.ConclusionWe have developed a nomogram to accurately predict the clinical outcomes of SNSCC patients. This model was effective and can help clinicians to improve patient counseling.
A case series of the dynamics of lipid mediators in patients with sepsis
Authors: Hamaguchi Mitsuhide , Wu Heng Ning , Tanaka Masahiro , Tsuda Noriko , Tantengco Ourlad Alzeus Gaddi , Matsushima Tomohide , Nakao Takami , Ishibe Takuya , Sakata Ikuhiro , Yanagihara Itaru 
Published: July 2019

BackgroundBioactive lipid mediators play a crucial role during infection. Previously, we showed the expression level of FAAH mRNA in septic patients was lower than in healthy controls.Case PresentationFour patients with a Sequential Organ Failure Assessment (SOFA) score of <7 recovered from sepsis. One patient with SOFA score of 12 on day 7 died on day 21. In the fatal case, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, and linoleic acid‐derived lipid mediators, including 9‐hydroxyoctadecadienoic acid (9‐HODE), 13‐HODE, 9,10‐dihydroxy‐12‐octadecenoic acid (9,10‐DiHOME), and 12,13‐DiHOME, were elevated on day 1. Increase in anti‐inflammatory prostaglandin E1 ethanolamide together with persistently lower transcription level of FAAH mRNA was detected on day 7 in the fatal case.ConclusionLipidomic analysis on day 1 revealed elevated linoleic acid metabolites, whereas on day 7, elevated prostaglandin E1 ethanolamide and low level of FAAH mRNA transcription were observed in the fatal case of sepsis.
Redox‐Inert Fe3+ Ions in Octahedral Sites of Co‐Fe Spinel Oxides with Enhanced Oxygen Catalytic Activity for Rechargeable Zinc–Air Batteries
Authors: Wang Xiao‐Tong , Ouyang Ting , Wang Ling , Zhong Jia‐Huan , Ma Tianyi , Liu Zhao‐Qing 
Published: July 2019

AbstractBimetallic cobalt‐based spinel is sparking much interest, most notably for its excellent bifunctional performance. However, the effect of Fe3+ doping in Co3O4 spinel remains poorly understood, mainly because the surface state of a catalyst is difficult to characterize. Herein, a bifunctional oxygen electrode composed of spinel Co2FeO4/(Co0.72Fe0.28)Td(Co1.28Fe0.72)OctO4 nanoparticles grown on N‐doped carbon nanotubes (NCNTs) is designed, which exhibits superior performance to state‐of‐the‐art noble metal catalysts. Theoretical calculations and magnetic measurements reveal that the introduction of Fe3+ ions into the Co3O4 network causes delocalization of the Co 3d electrons and spin‐state transition. Fe3+ ions can effectively activate adjacent Co3+ ions under the action of both spin and charge effect, resulting in the enhanced intrinsic oxygen catalytic activity of the hybrid spinel Co2FeO4. This work provides not only a promising bifunctional electrode for zinc–air batteries, but also offers a new insight to understand the Co‐Fe spinel oxides for oxygen electrocatalysis.
Glycine‐functionalized reduced graphene oxide for methylene blue removal
Authors: Wang Chubei , Ma Guoyang , Zhou Jianwei , Zhang Mingliang , Ma Xinfeng , Duo Fangfang , Chu Liangliang , Huang Jianxin , Su Xinmei 
Published: July 2019

Glycine‐functionalized reduced graphene oxide (GRGO) was prepared through the reaction of glycine and chlorine‐functionalized reduced graphene oxide. The product was characterized by SEM, HRTEM, IR, Raman, and XPS. The nitrogen content (8.28%) was high in product, peak at 285.8 eV was assigned to the C–N bond, which implied that the chlorine residues in raw material were substituted by amine group of glycine. The intensity ratio of D and G peak was about 1.5, which also implied that more saturated carbon atoms were present in the product. Results of SEM, IR, and XPS confirmed that glycine molecules were attached to graphene sheets. Compared with reduced graphene oxide (61.5 mg/g) and active carbon (45.2 mg/g), GRGO had a good adsorption capacity (98.9 mg/g) for methylene blue. The adsorption process was fitted to three kinetic models and three adsorption isotherm models. The adsorption process complied with pseudo‐second order kinetic model and Langmuir model.
Synthesis and characterization of a novel highly phosphonated water‐insoluble polymer
Authors: Alter Christian , Neumann Beate , Stammler Hans‐Georg , Hoge Berthold 
Published: July 2019

ABSTRACTA novel polymer, functionalized by tetrafluoroaryl phosphonic acid units, was prepared by free‐radical polymerization of the corresponding styrene monomer. The obtained polymer was analyzed by gel permeation chromatography, differential scanning calorimetry, and spectroscopy (NMR, IR). Ion exchange capacity of the water‐insoluble polymer was determined in methanol solution by titration with 0.1M NaOH. The proton conductivity of the polymer of 9.91 × 10−7 S cm−1 as disclosed by electrochemical impedance spectroscopy renders this polymer a promising candidate for solid electrolyte applications or as a water‐insoluble dopant for proton exchange membrane applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48235.
A Study of Graphene‐Based Copper Catalysts: Copper(I) Nanoplatelets for Batch and Continuous‐Flow Applications
Authors: De Angelis Sonia , Franco Mario , Triminì Alessandra , González Ana , Sainz Raquel , Degennaro Leonardo , Romanazzi Giuseppe , Carlucci Claudia , Petrelli Valentina , de la Esperanza Alejandro , Goñi Asier , Ferritto Rafael , Aceña José Luis , Luisi Renzo , Cid M. Belén 
Published: July 2019

AbstractThe use of graphene derivatives as supports improves the properties of heterogeneous catalysts, with graphene oxide (GO) being the most frequently employed. To explore greener possibilities as well as to get some insights into the role of the different graphenic supports (GO, rGO, carbon black, and graphite nanoplatelets), we prepared, under the same standard conditions, a variety of heterogeneous Cu catalysts and systematically evaluated their composition and catalytic activity in azide–alkyne cycloadditions as a model reaction. The use of sustainable graphite nanoplatelets (GNPs) afforded a stable CuI catalyst with good recyclability properties, which are compatible with flow conditions, and able to catalyze other reactions such as the regio‐ and stereoselective sulfonylation of alkynes (addition reaction) and the Meerwein arylation (single electron transfer process).
Zigzag‐Helix Transformation of Expanded Polyvaline Induced by Racemization
Authors: Okamura Taka‐aki , Tsubouchi Kyoko , Onitsuka Kiyotaka 
Published: July 2019

AbstractBiological macromolecules are essentially homochiral. For example, proteins mostly consist of l‐amino acids. What happens when a chiral molecule meets itself in a mirror? For expanded polyvaline, zigzag‐helix transformation occurs. In this study, expanded polyvalines containing bis(pyridine)silver(I) moieties were synthesized and isolated as single crystals. The molecular structures were determined by X‐ray analysis, which revealed that chiral expanded poly(l‐valine) and poly(d‐valine) form zigzag chains. However, racemic mixture of these molecules form left‐ and right‐handed 41 helices that retain the original sequences. These secondary structures can be transformed by only flipping the C‐terminal amide plane for each unit, which is reminiscent of the relationship between an α‐helix and a β‐strand. Such expanded polypeptides can be built up into expanded protein, forming a tailor‐made three‐dimensional structure, which will lead to new functions.
Divide and Stack Up: Boron‐Based Sandwich Cluster as a Subnanoscale Propeller
Authors: Wang Ying‐Jin , Feng Lin‐Yan , Zhai Hua‐Jin 
Published: July 2019

AbstractTypical salts are composed of positive and negative ions that appear alternatively, whereas decorated layered materials normally have ions anchored on the polygonal sites. In this way, the ions are spatially fixed and the system is stabilized on electrostatic grounds. Here we report on a unique boron‐lithium cluster, B7Li4−, which contains a disk‐like B7 core, being sandwiched by a Li3 ring and an isolated Li atom. All Li centers are stacked exactly on the B atoms from top or bottom, rather than being anchored on triangular B3 sites. The cluster shows dynamic fluxionality, whose Li3 ring rotates freely on the B7 disk even at below room temperature (200 K), akin to a subnanoscale propeller. The rotation barrier is only 0.37 kcal mol−1 at the single‐point CCSD(T) level. The sandwich shape facilitates intramolecular charge‐transfers, leading to a [Li3]+[B7]3−[Li]+ salt complex. The [Li3]+ layer has 2σ aromaticity, while [B7]3− core is robust with both π and σ sextets. Three‐fold π/σ aromaticity collectively stabilizes the system, as well as underlies its dynamic fluxionality. The interlayer bonding turns out to be strong, dominated by ionic interactions (of the order of 3–4 eV per Li3/Li unit). The work demonstrates a propeller at the subnanoscale, which is dynamically fluxional despite strong covalent and ionic bonding.
Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development
Authors: Croen Lisa A. , Qian Yinge , Ashwood Paul , Zerbo Ousseny , Schendel Diana , Pinto‐Martin Jennifer , Daniele Fallin M. , Levy Susan , Schieve Laura A. , Yeargin‐Allsopp Marshalyn , Sabourin Katherine R. , Ames Jennifer L. 
Published: July 2019

Maternal infection and fever during pregnancy have been implicated in the etiology of autism spectrum disorder (ASD); however, studies have not been able to separate the effects of fever itself from the impact of a specific infectious organism on the developing brain. We utilized data from the Study to Explore Early Development (SEED), a case–control study among 2‐ to 5‐year‐old children born between 2003 and 2006 in the United States, to explore a possible association between maternal infection and fever during pregnancy and risk of ASD and other developmental disorders (DDs). Three groups of children were included: children with ASD (N = 606) and children with DDs (N = 856), ascertained from clinical and educational sources, and children from the general population (N = 796), randomly sampled from state birth records. Information about infection and fever during pregnancy was obtained from a telephone interview with the mother shortly after study enrollment and maternal prenatal and labor/delivery medical records. ASD and DD status was determined by an in‐person standardized developmental assessment of the child at 3–5 years of age. After adjustment for covariates, maternal infection anytime during pregnancy was not associated with ASD or DDs. However, second trimester infection accompanied by fever elevated risk for ASD approximately twofold (aOR = 2.19, 95% confidence interval 1.14–4.23). These findings of an association between maternal infection with fever in the second trimester and increased risk of ASD in the offspring suggest that the inflammatory response to the infectious agent may be etiologically relevant. Autism Res 2019, 12: 1551–1561. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryUsing data from a large multisite study in the United States—the Study to Explore Early Development—we found that women who had an infection during the second trimester of pregnancy accompanied by a fever are more likely to have children with ASD. These findings suggest the possibility that only more severe infections accompanied by a robust inflammatory response increase the risk of ASD.
TGF‐β‐mediated regulation of plasminogen activators is human telomerase reverse transcriptase dependent in cancer cells
Authors: Jaiswal Rishi K. , Yadava Pramod K. 
Published: July 2019

AbstractTelomerase is a specialized reverse transcriptase/terminal transferase enzyme that adds telomeric repeat sequences at the extreme end of a newly replicated chromosome. Apart from telomere lengthening, telomerase has many extracurricular activities. Telomerase is known to regulate the expression of many genes and helps in cancer progression and epithelial‐to‐mesenchymal transitions (EMTs). We have previously reported that human telomerase reverse transcriptase (hTERT) regulates the expression of plasminogen activator such as urokinase‐type plasminogen activator (uPA) in cancer cells following a genome‐wide transcriptomic study. Here, we present data substantiating these results in terms of real‐time assays, western blots, and immunofluorescence. Another aim of this study is to find out the possible mechanism by which hTERT regulates the expression of plasminogen activators. We have used some molecular biology techniques such as quantitative real‐time polymerase chain reaction, western blotting, and immunofluorescence and some assays such as wound healing assay and colony formation assay to solve this question. In this study, we show a positive association between hTERT and uPA. We also demonstrate that hTERT enhances uPA expression concomitant with EMT. Knocking down of hTERT reduces uPA expression as well as reverses EMT in cancer cells. We have also found that uPA is a transforming growth factor beta (TGF‐β)‐induced protein. Our observations establish that TGF‐β‐induced uPA expression is hTERT dependent.
Resveratrol modulates epigenetic regulators of promoter histone methylation and acetylation that restores BRCA1, p53, p21CIP1 in human breast cancer cell lines
Authors: Chatterjee Biji , Ghosh Krishna , Kanade Santosh R. 
Published: July 2019

AbstractThe epigenetic enzymes catalyze posttranslational modifications (PTMs) of histones, which functionally determine gene expression at the chromatin level. Resveratrol (RVT) a much studied anti‐cancer natural molecule is known for restoration of BRCA1, p53, and p21 in cancer cells. We aimed to investigate the role of histone methylation and acetylation on upregulation of these tumor suppressor genes. Our results suggest RVT significantly increase expression of BRCA1, p53, and p21, while decreased expression of protein arginine methyltransferase 5 (PRMT5) and enhancer of Zeste homolog 2 (EZH2) at a 20 μM concentration by 48 hr in both MCF‐7 and MDA‐MB‐231 breast cancer cells. Also, there was an overall loss of H4R3me2s (catalytic product of PRMT5) and H3K27me3 (catalytic product of PRMT5). In contrast, RVT exposure caused a significant decrease in lysine deacetylase (KDAC) activity and expression of KDAC1‐3, whereas the expression of lysine acetyltransferase KAT2A/3B was increased compared to the unexposed cells. As an outcome, RVT increased global level of H3K9ac and H3K27ac marks. The chromatin immunoprecipitation showed 20 μM RVT exposure significantly reduced the enrichment of repressive histone marks (H4R3me2s and H3K27me3) while the abundance of activating histone marks (H3K9/27ac) within the proximal promoter region of BRCA1, p53, and p21 was increased. We hypothesize RVT by affecting the expression and function of methylation and acetylation enzymes altered the epigenetic modifications on promoter histones that restored expression of these critically important tumor suppressor genes.