bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatigue, symptom burden, and health‐related quality of life in patients with myelodysplastic syndrome, aplastic anemia, and paroxysmal nocturnal hemoglobinuria
Authors: Escalante Carmen P. , Chisolm Stephanie , Song Juhee , Richardson Marsha , Salkeld Ellen , Aoki Etsuko , Garcia‐Manero Guillermo 
Published: January 2019

AbstractBackgroundFatigue is distressing and affects quality of life (QoL) among patients with myelodysplastic syndrome (MDS), aplastic anemia (AA), and paroxysmal nocturnal hemoglobinuria (PNH). Limited data exist on the impact of fatigue, QoL, and related symptoms in these patients.ObjectiveProspectively assess fatigue (functional assessment of cancer therapy‐anemia [FACT‐An]); QoL (FACT‐An subscales); pain (brief pain inventory); and depression, anxiety, and stress (depression anxiety stress scale‐21) and strategies used to manage these symptoms in patients withMDS,AA, andPNH.MethodsSurveys were administered via theAAandMDSInternational Foundation website and database from October 2014 through April 2015 in a cross‐sectional study. Results were summarized using descriptive statistics.ResultsOf 303 patients, 145 (48%) hadMDS, 84 (28%) hadAA, and 74 (24%) hadPNH; 31 (10%) had >1 diagnosis. The mean age was 57 years, 200 (66%) were female, and 195 (92%) were white. The mean fatigue scores were 25 (range 1‐52) for the whole cohort, 28 forAA, 25 forMDS, and 24 forPNH(P = 0.117); these are all considered severe level. The mean QoL score was 68 (range 10‐104) for the whole cohort, 67 forAA, 69 forMDS, and 67 forPNH(P = 0.821). The ranges for stress were normal; pain and depression, mild; and anxiety, moderate. The most common management strategies perceived as helpful for fatigue in the past month were preserving energy, physical activity, and naps.ConclusionsMany patients withMDS,AA, andPNHreport severe fatigue. The helpfulness of fatigue management strategies may impact patients’ continued use; whether these strategies are beneficial and decrease fatigue levels needs more study.
Label‐Free in Situ Monitoring of the DNA Hybridization Chain Reaction by Using Sequence‐Selective Minor‐Groove‐Binding Fluorophores
Authors: Sakamoto Takashi , Yamada Rikuto 
Published: January 2019

AbstractA new label‐free in situ monitoring system for the hybridization chain reaction (HCR) based on DNA minor‐groove‐binding fluorophores [Hoechst 33258 (Hoe) or quinone cyanine‐dithiazole (QCy‐DT)] has been developed. Use of two unmodified hairpin oligodeoxyribonucleotides containing incomplete double‐stranded AATT sequences enabled target‐dependent formation of probe binding sites—that is, AATT double strand—in the HCR product, together with fluorescence enhancement of minor‐groove‐binding fluorophores in situ. This system allows target DNA to be detected through the fluorescence enhancement of Hoe and QCy‐DT in real time and in situ. Further development of a label‐free, isothermal detection system might provide a cost‐effective and user‐friendly method for nucleic acid detection.
Exploring a new structured professional judgment measure (impulsivity measure related to violence) after an average follow‐up of 10 years: A study of Finnish offenders
Authors: Weizmann‐Henelius Ghitta , Putkonen Hanna , Rissanen Teija , Eronen Markku , Webster Christopher D. 
Published: January 2019

AbstractBackgroundIdentification of the risk factors underlying impulsivity related to violent acts is an essential component of risk assessment and management to reduce violent offending.AimsOur aim was to develop a clinically useful measure for assessing impulsivity related to violence. Our research questions were which items in the newly developed measure are associated with later violent recidivism and what is the measure's predictive validity?MethodsA new scale, the impulsivity measure related to violence (IMP‐V), was studied by completing the scale, blind to outcome, from information in the forensic psychiatric examination reports of 63 of a 1‐year referral cohort of 181 Finnish offenders. Data on reoffending for up to 15 years after release were collected from official criminal records.ResultsThe predictive accuracy of the IMP‐V continuous ratings was 78% and for the categorical summary risk ratings 77%. Univariate analyses of categorical summary risk ratings of the risk factors revealed that, with two exceptions, each additional score on the IMP‐V was associated with a significant increase in violence recidivism.ConclusionsThese preliminary results indicate that the IMP‐V is a promising decision‐enhancing guide for assessing the risk of violence in impulsive people and that the measure is worth developing for use with impulsivity‐prone offenders and forensic psychiatric patients. The IMP‐V organises information on the nature of impulsivity in violence‐prone persons and thus also creates opportunities for more effective risk management.
Longitudinal Relaxation Optimization Enhances 1H‐Detected HSQC in Solid‐State NMR Spectroscopy on Challenging Biological Systems
Authors: Han Rong , Yang Yufei , Wang Shenlin 
Published: January 2019

AbstractSolid‐state (SS) NMR spectroscopy is a powerful technique for studying challenging biological systems, but it often suffers from low sensitivity. A longitudinal relaxation optimization scheme to enhance the signal sensitivity of HSQC experiments in SSNMR spectroscopy is reported. Under the proposed scheme, the 1H spins of 1H–X (15N or 13C) are selected for signal acquisition, whereas other vast 1H spins are flipped back to the axis of the static magnetic field to accelerate the spin recovery of the observed 1H spins, resulting in enhanced sensitivity. Three biological systems are used to evaluate this strategy, including a seven‐transmembrane protein, an RNA, and a whole‐cell sample. For all three samples, the proposed scheme largely shortens the effective 1H longitudinal relaxation time and results in a 1.3–2.5‐fold gain in sensitivity. The selected systems are representative of challenging biological systems for observation by means of SSNMR spectroscopy; thus indicating the general applicability of this method, which is particularly important for biological samples with a short lifetime or with limited sample quantities.
Photomechanical Organic Crystals as Smart Materials for Advanced Applications
Authors: Yu Qi , Aguila Briana , Gao Jia , Xu Peixin , Chen Qizhe , Yan Jie , Xing Dong , Chen Yao , Cheng Peng , Zhang Zhenjie , Ma Shengqian 
Published: January 2019

AbstractPhotomechanical molecular crystals are receiving much attention due to their efficient conversion of light into mechanical work and advantages including faster response time; higher Young's modulus; and ordered structure, as measured by single‐crystal X‐ray diffraction. Recently, various photomechanical crystals with different motions (contraction, expansion, bending, fragmentation, hopping, curling, and twisting) are appearing at the forefront of smart materials research. The photomechanical motions of these single crystals during irradiation are triggered by solid‐state photochemical reactions and accompanied by phase transformation. This Minireview summarizes recent developments in growing research into photoresponsive molecular crystals. The basic mechanisms of different kinds of photomechanical materials are described in detail; recent advances in photomechanical crystals for promising applications as smart materials are also highlighted.
Construction of a Noncentrosymmetric Luminescent Coordination Polymer from [BaL3] Unit (L = Pyridine‐2,6‐dicarboxylate Acid) and Li(I) Ion
Authors: Song Ying , Wu Zhaofeng , Hu Bing , Huang Xiaoying 
Published: January 2019

Summary of main observation and conclusionThis work presents the synthesis, crystal structure and properties of a novel noncentrosymmetric (NCS) coordination polymer (CP), namely, (Me2NH2)3[BaLi(2,6‐PyDC)3(H2O)] (1) (2,6‐PyDC = pyridine‐2,6‐dicarboxylate acid), which represents the first example of BaLi‐CPs with 2,6‐PyDC ligand. Single‐crystal X‐ray structural analysis reveals that the compound features a two‐dimensional (2D) layered structure. The simplified structure of each layer belongs to the hcb topology. The second harmonic generation (SHG) response of 1 is about 0.5 times that of KH2PO4 (KDP) marker. What is more, 1 emits bright blue light upon the excitation of 365 nm UV light with the quantum yield (QY, Φ) of 1.63%. The successful construction of this compound convinces the feasibility of constructing NCS CPs via the combination of [BaL3] unit and Li(I) ion.
Cortical and thalamic connectivity of posterior parietal visual cortical areas PPc and PPr of the domestic ferret (Mustela putorius furo)
Authors: Dell Leigh‐Anne , Innocenti Giorgio M. , Hilgetag Claus C. , Manger Paul R. 
Published: January 2019

AbstractThe present study describes the ipsilateral and contralateral cortico‐cortical and cortico‐thalamic connectivity of the parietal visual areas, posterior parietal caudal cortical area (PPc) and posterior parietal rostral cortical area (PPr), in the ferret using standard anatomical tract‐tracing methods. The two divisions of posterior parietal cortex of the ferret are strongly interconnected, however area PPc shows stronger connectivity with the occipital and suprasylvian visual cortex, while area PPr shows stronger connectivity with the somatomotor cortex, reflecting the functional specificity of these two areas. This pattern of connectivity is mirrored in the contralateral callosal connections. In addition, PPc and PPr are connected with the visual and somatomotor nuclei of the dorsal thalamus. Numerous connectional similarities exist between the posterior parietal cortex of the ferret (PPc and PPr) and the cat (area 7 and 5), indicative of the homology of these areas within the Carnivora. These findings highlight the existence of a frontoparietal network as a shared feature of the organization of parietal cortex across Euarchontoglires and Laurasiatherians, with the degree of expression varying in relation to the expansion and areal complexity of the posterior parietal cortex. This observation indicates that the ferret is a potentially valuable experimental model animal for understanding the evolution and function of the posterior parietal cortex and the frontoparietal network across mammals. The data generated will also contribute to a connectomics database, to further cross‐species analyses of connectomes and illuminate wiring principles of cortical connectivity across mammals.
Tuning Selectivity and Sensitivity of Mixed‐polymeric Tetraruthenated Metalloporphyrins Modified Electrodes as Voltammetric Sensors of Chloramphenicol
Authors: Ferreira Luís Marcos Cerdeira , Martins Paulo Roberto , Araki Koiti , Angnes Lúcio 
Published: January 2019

AbstractMixed Ni−Co tetraruthenated porphyrin films were successfully electropolymerized on glassy carbon electrodes in alkaline solutions (pH=13) of NiTRP and CoTRP, giving excellent electrocatalytic responses for determination of the antibiotic drug chloramphenicol. Electrodes with four different compositions were obtained by varying the ratio of NiTRP and CoTRP in the deposition solution. For the characterization of these materials, SEM, ICP‐MS, EIS and CV were explored. The porphyrin modified glassy carbon electrodes presented two oxidation peaks for chloramphenicol (except for Ni‐25). The potential shifted to lower values as the percentage of CoTRP increased decreasing its oxidation potential in more than 200 mV for Ni‐50 as compared to Ni‐100. Interestingly, the materials with cobalt content larger than 50 % did not show the typical catalytic response of the NiIIIOOH species, but rather showed an increase in current at potentials larger than 0.4 V, demonstrating the key role played by nickel in this type of materials. The composition of polymeric mixed porphyrin materials influenced the oxidation current response of both redox waves, resulting in different sensitivities on the calibration curves.
Preoperative neutrophil lymphocyte ratio but not platelet lymphocyte ratio predicts survival and early relapse in patients with oral, pharyngeal, and lip cancer
Authors: Yu Wenjie , Dou Yu , Wang Ketao , Liu Yanguo , Sun Jintang , Gao Han , Liu Shaohua , Wei Fengcai , Yuan Daoying , Song Xiaobin , Qu Xun 
Published: January 2019

AbstractBackgroundTo evaluate the prognostic value of preoperative neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in oral, pharyngeal, and lip cancer for survival and relapse.MethodsClinic‐pathologic and hematological records were retrospectively retrieved. Patients completed follow‐up period were included for survival and relapse analysis.ResultsThe preoperative NLR value was a prognostic factor for both overall survival and relapse‐free survival. The high NLR group demonstrated higher total relapse rate, higher local relapse rate, and higher relapse rate within 12 months. However, the preoperative PLR did not associate with survival or relapse.ConclusionsThe preoperative NLR, not PLR, is an independent prognostic indicator of survival. It also exhibits predictive value for relapse, particularly early relapse within 12 months. The preoperative NLR value might be recommended as a useful tool for predicting the outcomes and stratifying patients for different management strategies.
Paraganglioma of the head and neck region, treated with radiation therapy, a Rare Cancer Network study
Authors: Lassen‐Ramshad Yasmin , Ozyar Enis , Alanyali Senem , Poortmans Philip , van Houtte Paul , Sohawon Schoeb , Esassolak Mustafa , Krengli Marco , Villa Salvador , Miller Robert , Demiroz Candan , Akyurek Serap , Aggerholm‐Pedersen Ninna , Thariat Juliette 
Published: January 2019

AbstractBackgroundParaganglioma of the head and neck (HNPGL) are rare often benign tumors. Surgery and radiation therapy (RT) are the main treatment choices. We present an analysis of outcome and toxicity after RT from 13 institutions of the Rare Cancer Network.MethodsData were collected using a questionnaire concerning patients' characteristics, treatment, and outcome. A total of 81 patients with 82 HNPGL were analyzed.ResultsThe median follow‐up was 48 months (1‐456). Sixty‐two lesions were treated with conventional RT and 20 lesions with stereotactic RT. Local control (LC) was achieved in 69 out of 77 lesions. Late toxicity occurred in 17 patients. Patients treated with stereotactic RT experienced neither disease progression nor late toxicity. Four patients with a follow‐up longer than 20 years experienced disease progression.ConclusionRT for HNPGL offered good local control with acceptable toxicity. Stereotactic RT might offer better results. Long‐term follow‐up is required.
Importance of tumor budding grade as independent prognostic factor for early tongue squamous cell carcinoma
Authors: Ebihara Yasuhiro , Yoshida Saori , Nakahira Mitsuhiko , Kogashiwa Yasunao , Enoki Yuichiro , Kuba Kiyomi , Inoue Hitoshi , Minami Kazuhiko , Yasuda Masanori , Sugasawa Masashi 
Published: January 2019

AbstractBackgroundFactors involved in neck lymph node metastasis (NLM) and prognosis of early tongue squamous cell carcinoma (SCC) remain unknown.MethodsWe analyzed disease‐specific survival (DSS) and NLM including tumor budding grade (TBG) among 64 patients with cT1/2N0 tongue SCC.ResultsUnivariate analysis of DSS of primary lesions uncovered significant differences in new cT, pT, new pT, pDiameter, venous infiltration, and TBG. Multivariate analysis selected only TBG3 as a predictor of NLM (odds ratio, 9.55; 95% confidence interval [CI], 1.80‐50.8; P = .008), and a prognostic factor for DSS (hazard ratio, 4.41; 95% CI, 1.34‐14.5; P = .02).ConclusionThe sole predictor of NLM and the prognosis of early tongue SCC was TBG, indicating that it might help to select overwhelming risk patients.
Vitamin E: Regulatory role on gene and protein expression and metabolomics profiles
Authors: Kim Hye‐Kyeong , Han Sung Nim 
Published: January 2019

AbstractResults from microarray analyzes have shown that both vitamin E deficiency and supplementation have a significant impact on the gene expression of various tissues and cells. Genes that were modulated by vitamin E supplementation were different depending on the tissue, which suggested that changes in gene expression are reflective of tissue function and the tissue‐specific regulation of vitamin E. In addition, the magnitude of gene expression and types of genes whose expression was altered were differentially affected by the vitamin E forms used for intervention. Metabolite analyzes have provided better understanding of the vitamin E metabolic pathway and have established evidence for the regulation of energy, lipid, and glucose metabolism by vitamin E. However, there are a limited number of studies that have applied advanced genomics, proteomics, and metabolomics technologies to investigate vitamin E's biological functions and mechanisms of action. In this review, the effects of vitamin E on gene and protein expression investigated by microarray, transcriptome, and proteomics analysis are discussed. © 2019 IUBMB Life, 71(4):442–455, 2019
Fibrinopeptide A induces C‐reactive protein expression through the ROS‐ERK1/2/p38‐NF‐κB signal pathway in the human umbilical vascular endothelial cells
Authors: Zhao Jing , Xu Shou‐zhu , Liu Juntian 
Published: January 2019

AbstractAtherosclerosis is a chronic inflammatory disease of the arterial wall. Inflammation causes endothelial injury and dysfunction, which is an initial step of atherosclerosis. Fibrinopeptide A (FPA) is a biomarker of the activation of the coagulation system, and a high concentration of FPA in the blood occurs in patients with ischemic cardiocerebrovascular diseases. The present research observed that FPA stimulated the generation of C‐reactive protein (CRP), IL‐1β, and IL‐6 in human umbilical vascular endothelial cells (HUVECs); and anti‐IL‐1
β and anti‐IL‐6 neutralizing antibodies did not alter FPA‐induced CRP expression in HUVECs. The subchronic administration of FPA into rats increased the plasma FPA and CRP levels. Further studies showed that FPA stimulated superoxide anion generation, activated ERK1/2 and p38, promoted nuclear factor κB (NF‐κB) nuclear translocation, and raised the NF‐κB level in the nuclei of HUVECs. Antioxidant N‐acetylcysteine (NAC), complex II inhibitor thenoyltrifluoroacetone (TTFA), and NADPH oxidase inhibitor diphenyleneiodonium (DPI) inhibited FPA‐stimulated generation of superoxide anion, and NAC reduced FPA‐induced expressions of the phosphorylated ERK1/2 and p38. NAC, TTFA, DPI, inhibitors of ERK1/2, p38, and NF‐κB all downregulated FPA‐induced CRP expression. These results indicate that FPA induces CRP expression in HUVECs via the ROS‐ERK1/2/p38‐NF‐κB signal pathway. Moreover, this is the first report that FPA produces a proinflammatory effect on the vascular endothelial cells.
SRPK1 facilitates tumor cell growth via modulating the small nucleolar RNA expression in gastric cancer
Authors: Li Yandong , Yu Shijun , Wang Xiao , Ye Xiaojuan , He Bin , Quan Ming , Gao Yong 
Published: January 2019

AbstractSerine‐arginine protein kinase 1 (SRPK1) is the main regulator in alternative splicing by phosphorylating splicing factors rich in serine/arginine repeats. Its overexpression has been found in multiple cancer types and contributes to cancer development. Here we report the role of SRPK1 and underlying mechanism in gastric cancer (GC) cell growth. We found that SRPK1 was frequently upregulated in GC samples compared with their adjacent corresponding normal tissues by immunohistochemistry and western blot analysis. Knockdown of SRPK1 in GC cells suppressed cell growth in cell viability assays, colony formation assays and nude mice xenograft model, whereas overexpression of SRPK1 promotes opposite phenotypes in these assays. By a complementary DNA microarray analysis, we found that SRPK1 knockdown had significant inhibitory effects on a majority of small nucleolar RNAs expression. Among them, snoRA42, snoRA74A, and snoRD10 were selected for further functional experiments. Cell growth curves on a plate and in soft agar indicated that the three snoRNAs play potential oncogenic function in GC. In addition, SRPK1 could co‐immunoprecipitated with NCL, a nucleolar phosphoprotein involved in the synthesis and maturation of ribosomes. These results suggested that SRPK1 contributes to GC development by a new possible mechanism involving snoRNAs mediated signaling.
Loss of ENT1 increases cell proliferation in the annulus fibrosus of the intervertebral disc
Authors: Veras Matthew A. , Tenn Neil A. , Kuljanin Miljan , Lajoie Gilles A. , Hammond James R. , Dixon S. Jeffrey , Séguin Cheryle A. 
Published: January 2019

AbstractMice lacking equilibrative nucleoside transporter 1 (ENT1
−/−) demonstrate progressive calcification of spinal tissues including the annulus fibrosus (AF) of the intervertebral disc (IVD). We previously established ENT1 as the primary nucleoside transporter in the AF and demonstrated dysregulation of biomineralization pathways. To identify cellular pathways altered by loss of ENT1, we conducted microarray analysis of AF tissue from wild‐type (WT) and ENT1
−/− mice before calcification (2 months of age) and associated with calcification (6 months of age). Bioinformatic analyses identified cell cycle dysregulation in ENT1
−/− AF tissues and implicated the E2f family of transcription factors as potential effectors. Quantitative polymerase chain reaction analysis confirmed increased expression of multiple E2f transcription factors and E2f interacting proteins (
Rb1 and Cdk2) in ENT1
−/− AF cells compared with WT at 6 months of age. At this time point, ENT1
−/− AF tissues showed increased JNK MAPK pathway activation, CDK1, minichromosome maintenance complex component 5 (Mcm5), and proliferating cell nuclear antigen (PCNA) protein expression, and PCNA‐positive proliferating cells compared with WT controls. The current study demonstrates that loss of ENT1‐mediated adenosine transport leads to increased cell proliferation in the AF of the IVD.
Long non‐coding RNA metastasis‐associated lung adenocarcinoma transcript 1/microRNA‐202‐3p/periostin axis modulates invasion and epithelial–mesenchymal transition in human cervical cancer
Authors: Han Xiting , Wang Qian , Wang Yan , Hu Bin , Dong Xue , Zhang Hailing , Wang Wuliang 
Published: January 2019

AbstractThe human cervical cancer (CC) has been identified as one of the most common tumors in women, and the molecular regulation in CC still remains unclear. The dysregulation of periostin has been found in a variety of cancers, but whether it is involved in the regulation of CC is unknown. The present study aimed to investigate the biological roles of periostin in CC and to explore the potential molecular regulation mechanisms. Here we found that the expression of periostin was overexpressed in CC tissues and CC cell lines (HeLa and SiHa). Knockdown of periostin in HeLa or SiHa cells significantly decreased cell viability, cell migration and invasion, and reduced epithelial–mesenchymal transition (EMT). Moreover, periostin knockdown suppressed the activation of Akt/the mammalian target of rapamycin (mTOR) signaling pathway, which is crucial for periostin to regulate the above biological activities in CC cells. Furthermore, we found that the periostin expression was positively correlated with the expression of metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1), and negatively correlated with the expression of microRNA (miR)‐202‐3p in CC tissues. We confirmed that MALAT1 positively regulated the expression of periostin by negatively modulating miR‐202‐3p. In addition, the MALAT1/miR‐202‐3p/periostin axis was deeply associated with the regulation of the cell viability, cell migration and invasion, and EMT in CC cells. Taken together, these findings suggest that periostin, which can be regulated by the MALAT1‐miR‐202‐3p axis, plays an important role in regulating cell viability, cell migration and invasion, and EMT of CC cells via activating Akt/mTOR signaling.