bluuebunny/crossref_metadata_2025_split huggingface dataset:
The process supporting the emergence of the environmental innovation capabilities within small businesses: An empirical investigation
Authors: Ferraro Giovanna , Passaro Renato , Quinto Ivana , Thomas Antonio 
Published: November 2024

AbstractFor several years, companies have made strategic changes to align with sustainable development principles by developing eco‐innovations. While research consistently highlights the positive impact of eco‐innovations on organisational performance, the factors driving these initiatives—particularly within small and medium‐sized enterprises (SMEs)—remain less clear. This inconsistency is due to the heterogeneity of SMEs and their high sensitivity to external contexts. To address this issue, our study delves into the role of competencies, technological factors and networking in shaping the environmental innovation capabilities of a homogeneous SME population in terms of sector, age, size, legal status, geographical location and orientation towards innovation. Using the partial least squares approach, we find that competencies and technological factors are the key drivers of eco‐innovation, while networking shows no significant effect. These findings contribute to the existing literature by underlining the fundamental importance of internal skills and technological adoption for fostering eco‐innovation. They also suggest that networking becomes essential in environments lacking robust public and private support mechanisms for SME growth. Considering the rapid and turbulent changes, driven by the dual needs of sustainability and competitiveness, our results offer useful and critical advice for policymakers to define more appropriate and effective policies.
A Multidisciplinary Consensus‐Building Exercise to Define and Prioritize Topics in Supportive Care of Children With Cancer at a Global Level
Authors: Sniderman Elizabeth , Reljic Tea , Bhakta Manoo , Bonilla Miguel , Clyce Julie , Farmer Jessica , Key Monica , Licona Sergio , Pauley Jennifer L. , Torres‐Gonzalez Alondra , Sullivan Michael , Bhakta Nickhill , Kumar Ambuj , Mukkada Sheena 
Published: November 2024

ABSTRACTIntroductionOptimal outcomes during childhood cancer treatment require effective management of toxicities, often called supportive care. A lack of agreement on what comprises supportive care limits the development and provision of comprehensive guidance (for this work, we have defined supportive care as any disease‐ or treatment‐related condition experienced by children with cancer, excluding psychosocial conditions, palliative care, survivorship, or procedural topics). To address this gap, we conducted a consensus‐building exercise among global experts to define and prioritize topics for supportive care.MethodsTwo rounds of brainstorming and prioritization exercises were conducted. A multidisciplinary panel nominated by professional societies and cooperative groups was formed to ensure geographic and resource representation using snowball sampling. An internal expert panel generated an initial list of supportive care topics. In round one, the multidisciplinary panel reviewed the initial list and recommended additional topics, followed by prioritization in round two using a seven‐point Likert scale. Results were summarized using descriptive statistics.ResultsThe multidisciplinary panel consisted of 57 members representing 32 countries. The initial list included 46 topics; 161 additional topics were suggested. After removing duplicates and out‐of‐scope additions, the final list contained 62 topics. Febrile neutropenia, sepsis, bloodstream infections, and pain were ranked highest priority. Mortality, morbidity, and frequency of the event were identified as the most important factors influencing prioritization.ConclusionThrough a multidisciplinary and globally representative process, we identified core supportive care topics and factors influencing their prioritization for childhood cancer. Outputs from this work will inform efforts to generate resource‐adapted recommendations for a global audience. This supports ongoing WHO CureAll work to develop a health systems‐level policy brief of supportive care requirements in the management of children with cancer.
Transarterial Infusion Chemotherapy and Embolization for Patients With Unresectable Advanced Cancer of Stomach or Gastroesophageal Junction: A Retrospective Study
Authors: Min Lingqiang , Liu Zheng , Zhou Bo , Zhou Peng , Luo Rongkui , Ding Yuqin , Cui Yuehong , Shi Zhongyi , Gu Yuan , Sun Yihong , Tang Zhaoqing , Wang Xuefei 
Published: November 2024

ABSTRACTPurposeThe feasibility of transarterial infusion chemotherapy and embolization (TAICE) in the treatment of advanced gastric cancer remains unclear. This study explored the value of TAICE in patients with unresectable locally advanced or metastatic cancer of stomach or gastroesophageal junction (GEJ).MethodsPatients with unresectable gastric cancer who received TAICE for tumor hemorrhage cessation were enrolled in this retrospective study. TAICE was performed using the Seldinger method. The tumor feeding artery was selected for infusion chemotherapy and then was embolized by microspheres or gelatin sponge. Patients involved in this study received one to four cycles TAICE with one to three drugs in the regimen. The possibility of surgery was evaluated after TAICE. Objective response rate (ORR), disease control rate (DCR), R0 resection rate, pathological complete remission (pCR) rate, major pathological remission (MPR) rate, progression‐free survival (PFS), overall survival (OS), and safety were analyzed.ResultsBetween January 2015 and December 2020, a total of 27 patients received a median of 2 (range, 1–4) cycles of TAICE. ORR and DCR were 33.3% and 74.0%, respectively. Eighteen patients received surgery, and 15 of them underwent gastrectomy and D2 lymph node dissection, with an R0 resection rate of 83.3% (15/18). Four (26.7%, 4/15) patients achieved MPR, but none achieved pCR. The median PFS was 19.8 months (95%CI, 12.1–40.0), and the median OS was 36.1 months (95%CI, 21.0–not reached). Patients with gastrectomy had significantly longer PFS (40.0 vs. 9.5 months, p < 0.0001) and OS (not reached vs. 16.6 months, p < 0.0001) than those without gastrectomy. All the TAICE‐related adverse events were manageable, with the most common being fatigue (100%), nausea (63.0%), and vomiting (55.6%). No severe surgical complications occurred.ConclusionTAICE was well‐tolerated and could be a potential therapy to provide opportunity of surgery for patients with unresectable advanced gastric or GEJ cancer.
Phytochemical Profiling and Anti‐VanA Activity of Pulegone Extracted from Ziziphora tenuior Flower Against Vancomycin‐Resistant Enterococci: An In Silico Approach
Authors: Hatami Asma , Paeizi Marzieh , Sadeghi Majid M. M. 
Published: November 2024

AbstractZiziphora tenuior is a herb known for its potent pharmaceutical activities. However, the specific compounds of the flowers of this herb have not been fully studied yet. This study used GC‐MS to conduct a chemical analysis of the methanol and dichloromethane extracts of Z. tenuior flowers. Additionally, it sought to assess the potential antibacterial activity of the extracts against vancomycin‐resistant enterococci (VRE) bacteria by predicting the interactions between one of the most prevalent compounds in the extracts and the D‐alanyl‐D‐lactate ligase (VanA) protein, which is responsible for enterococci resistant to vancomycin. The results revealed a total of 15 compounds in the methanolic extract and 12 compounds in the dichloromethane extract. Among these, 5‐methyl‐2‐(1‐methylethylidene)‐cyclohexanone, also known as pulegone, constituting 52.6 % of the methanolic extract and 34.6 % of the dichloromethane extract, was the most abundant compound in the extracts. Furthermore, the in‐silico analysis demonstrated that pulegone exhibited significant interactions with VanA, as indicated by docking energy values of −7 kcal/mol and the formation of one hydrogen bond. The study suggests that pulegone shows promise as an antibacterial agent against VRE by potentially interacting with VanA protein and serving as a key inhibitor in fighting vancomycin resistance.
Impact of lipids removal on the color, cooking characteristics, textural properties, and UHPLC‐QToF‐IMS‐based metabolites of Indian brown rice using supercritical carbon dioxide
Authors: Kumar Arun , Mudgal Swasti , Jain Ishika , Singh Narpinder 
Published: November 2024

AbstractBackground and ObjectivesThe study investigated the effect of lipid extraction by using the supercritical carbon dioxide (sCO2) process from brown rice (BR) of different Indian rice varieties (PB386, PB3, PB1121, PB1637, PR122, PR123, PR129, and PR113). BR was evaluated for color, pasting, cooking, and textural properties. UHPLC‐QToF‐IMS analysis was also carried out to make a comparison in fatty, phenolic, and amino acid profiles between BR of different varieties.FindingsDefatted BR (DBR) from all varieties exhibited increased L* (Lightness) while lower a* (redness to greenness) and b* (yellowness to blueness) than BR. Cooking time and hardness decreased, and water uptake increased in both types of DBR. Defatting of BR increased peak viscosity while it decreased pasting temperature in all the varieties. Fatty acids and phenolic acids compounds decreased while minor increases in amino acids were observed on defatting in all the varieties.ConclusionTherefore, sCO2 extraction was observed as a promising alternative to conventional methods like polishing to enhance the organoleptic and nutritional quality of the rice.
Dynamic Multiblock Regression for Process Modelling
Authors: Cattaldo Marco , Ferrer Alberto , Måge Ingrid 
Published: November 2024

ABSTRACTThe study introduces three novel strategies for incorporating capabilities for dynamic modelling into multiblock regression methods by integrating sequentially orthogonalised partial least squares (SO‐PLS) with different dynamic modelling techniques. The study evaluates these strategies using synthetic datasets and an industrial example, comparing their performance in predictive ability, identification of process dynamics, and quantification of block contributions. Results suggest that these approaches can effectively model the dynamics with performance comparable to state‐of‐the‐art methods, providing, at the same time, insight into the dynamic order and block contributions. One of the strategies, sequentially orthogonalised dynamic augmented (SODA)–PLS, shows promise by ensuring that redundant information in the time dimension is not included, resulting in simpler and more easily interpretable dynamic models. These multiblock dynamic regression strategies have potential applications for improved process understanding in industrial settings, especially where multiple data sources and inherent time dynamics are present.
π‐mers and π‐dimers: Two Radical Supramolecular Interactions – A Tutorial Review
Authors: Joseph Jean , Berville Mathilde , Wytko Jennifer , Weiss Jean , Jacquot de Rouville Henri‐Pierre 
Published: November 2024

AbstractIn this review, the difference between π‐mers (pimers) and π‐dimers (pi‐dimers) will be discussed. Often interchanged or confused in the literature, these two radical interactions lead to different or even opposite physico‐chemical behaviors. This review aims at clarifying the terms π‐mers and π‐dimers and at describing their main physico‐chemical properties to address their differences. Finally, selected literature examples exhibiting the successive formation of π‐mers and π‐dimers within the same systems will be detailed to emphasize the physico‐chemical changes occurring upon conversion.
An Efficient Bifunctional Core‐Shell ZIF‐90@ZIF‐67 Composite as a Stable Pickering Interfacial Catalyst for the Deacetalization–Knoevenagel Tandem Reaction
Authors: Liu Wei , Zhang Yu‐Qing , Dong Zhen‐Lin , Chen Zi‐Xuan , Li Lei , Zhao Xin‐Yuan , Wu Yang , Zhang Yu‐Yang 
Published: November 2024

AbstractExploiting advanced solid particles is crucial to the construction of Pickering emulsions catalysis. Recently, metal‐organic frameworks (MOFs) have been used as ideal emulsifiers stabilizing Pickering emulsions for interfacial catalysis. Although Pickering emulsions stabilized by core‐shell MOFs have significant importance in practical studies, to date there have been very limited reports on this topic. Herein, ZIF‐90@ZIF‐67, a core‐shell material with simultaneous acid‐base bifunctionality, was synthesized by seeded epitaxial growth. It was firstly applied as an emulsifier in Pickering emulsions to catalyze the deacetalization‐Knoevenagel tandem reaction, which exhibited excellent catalytic properties and achieved extremely high yields. Additionally, ZIF‐90@ZIF‐67 showed high stability and remained well repeatable after five cycles. This work provides a platform for the design of structurally and functionally diverse MOF‐based Pickering emulsions interfacial catalysis.
Retrospective analysis of HPV infection: Cotesting and HPV genotyping in cervical cancer screening within a large academic health care system
Authors: Feng Frances Xiuyan , Birdsong George G. , Wei Jane , Dababneh Melad N. , Reid Michelle D. , Hoskins Michael , Wang Qun 
Published: November 2024

AbstractBackgroundIn 2019, the American Society for Colposcopy and Cervical Pathology introduced fundamental shifts toward “risk‐based” guidelines, with human papillomavirus (HPV) genotyping as a principal test for investigating squamous intraepithelial lesions. This study aims to provide practice‐based evidence and supplement the updated guidelines by investigating HPV demographic distribution and uncovering the pathological features of high‐grade squamous intraepithelial lesions (HSILs) caused by high‐risk HPV (hrHPV) subtypes.MethodsPatients who underwent Papanicolaou screening and HPV testing in two hospital systems over the course of 4 years were recruited. The cytology results were categorized on the basis of the 2014 Bethesda classification. DNA sequences of 14 types of hrHPV were detected by Aptima test. The histological features of HSILs caused by different subtypes were compared between biopsies and excisions.ResultsA total of 63,709 cases were included. The HPV prevalence was 14.70%, predominantly in the 30 to 39‐year‐old age group, with slightly higher rates observed in African Americans. There was no significant racial distribution difference between HPV 16/18/45 and other types. HPV 16/18/45 infection was directly correlated with the severity of abnormal cytology, although the other subtypes were the major causes of cytological abnormalities. The trend for HPV prevalence was consistent across calendar years, and was associated with 8.77% negative for intraepithelial lesion or malignancy, 30.46% atypical squamous cell of undetermined significance, 64.62% low‐grade squamous intraepithelial lesion, 66.75% atypical squamous cell‐cannot exclude a high‐grade squamous intraepithelial lesion, and 91.80% HSIL. Furthermore, 29.09% of HSILs associated with other subtypes were not detectable on subsequent resections.ConclusionsGiven the HPV demographic distribution and the histological features of HSILs caused by different subtypes, cotesting with reflex HPV genotyping in specific populations, or expanding the subtypes in the primary HPV screening test, should be considered.
Analysis of the sensitivity of high‐grade squamous intraepithelial lesion Pap diagnosis and interobserver variability with the Hologic Genius Digital Diagnostics System
Authors: Harinath Lakshmi , Elishaev Esther , Ye Yuhong , Matsko Jonee , Colaizzi Amy , Wharton Stephanie , Bhargava Rohit , Pantanowitz Liron , Zhao Chengquan 
Published: November 2024

AbstractBackgroundArtificial intelligence (AI)–based systems are transforming cytopathology practice. The aim of this study was to evaluate the sensitivity of high‐grade squamous intraepithelial lesion (HSIL) Papanicolaou (Pap) diagnosis assisted by the Hologic Genius Digital Diagnostics System (GDDS).MethodsA validation study was performed with 890 ThinPrep Pap tests with the GDDS independently. From this set, a subset of 183 cases originally interpreted as HSIL confirmed histologically were included in this study. The sensitivity for detecting HSIL by three cytopathologists was calculated.ResultsMost HSIL cases were classified as atypical glandular cell/atypical squamous cell–high grade not excluded (AGC/ASC‐H) and above by all cytopathologists. Of these cases, 11.5% were classified as low‐grade squamous intraepithelial lesion (LSIL) by pathologist A (P‐A), 6% by pathologist B (P‐B), and 5.5% by pathologist C (P‐C); 3.8%, 2.7%, and 1.6% of these cases were classified as atypical squamous cell of unknown significance (ASC‐US) by P‐A, P‐B, and P‐C, respectively. The sensitivity for detection of cervical intraepithelial neoplasia 2 and above (CIN2+) lesions was 100% if ASC‐US and above (ASC‐US+) abnormalities were counted among all three pathologists. The sensitivity for detection of CIN2+ lesions was 84.7%, 91.3%, and 92.9% by P‐A, P‐B, and P‐C, respectively, for ASC‐H and above abnormalities. The Kendall W coefficient was 0.722, which indicated strong agreement between all pathologists.ConclusionsNew‐generation AI‐assisted Pap test screening systems such as the GDDS have the potential to transform cytology practice. In this study, the GDDS aided in interpreting HSIL in ThinPrep Pap tests, with good sensitivity and agreement between the pathologists who interacted with this system.
Low‐Dose Cone‐Beam Computed Tomography in Swedish Pediatric Patients With Alveolar Clefts Following Alveolar Bone Grafting—A Clinical Study
Authors: Vicente António , Cederhag Josefine , Rashidi Nilofar , Wiedel Anna‐Paulina , Becker Magnus , Brogårdh‐Roth Susanne , Shi Xie‐Qi , Hellén‐Halme Kristina 
Published: November 2024

ABSTRACTObjectivesThe aim of this study was to investigate whether a low‐dose cone‐beam computed tomography (CBCT) protocol provides diagnostically acceptable image quality for assessing bone healing after alveolar bone grafting.Material and MethodsThe study cohort comprised 11 patients (aged 7–14 years) with orofacial clefts who had undergone alveolar bone grafting at Skåne University Hospital in Malmö, Sweden. During the postsurgical follow‐up at 6 months, each patient was assessed twice: once with a standard‐dose CBCT protocol and once with a low‐dose CBCT protocol, which in total corresponds to one CBCT examination made with the exposure settings recommended by the manufacturer. Among others, the assessed parameters included subjective image quality, as well as bone graft height, thickness, and integration.ResultsNo significant differences were found between the standard‐ and low‐dose protocols for most parameters (p > 0.05). Exceptions included subjective image quality (one observer, p = 0.05) and confidence levels during the assessment (three observers, p = 0.01, 0.01, 0.02).ConclusionsThe low‐dose protocol yielded adequate image quality for postoperative CBCT healing assessment in patients who have undergone alveolar bone grafting. However, the confidence level of observers during the assessment with the low‐dose protocol was reduced. This study is registered on ClinicalTrials.gov (NCT06395077).Clinical Trial RegistrationThis study is registered on ClinicalTrials.gov (NCT06395077).
Education and Communication on the Topic of Osteonecrosis of the Jaw When Taking Bone‐Stabilizing Drugs
Authors: Saur Franz Gustav , Keinki Christian , Cramer Alin , Buentzel Jens , Hübner Jutta 
Published: November 2024

ABSTRACTObjectivesThe aim of this study was to analyze the communication between doctors and patients who were taking bone‐stabilizing medication and in rare cases developed osteonecrosis of the jaw as a result.Material and MethodsA standardized questionnaire recorded deficits based on patient experiences. These data were used to develop solution strategies for improving doctor–patient communication and the benefit–risk assessment of medication use.ResultsMost patients were satisfied with the information provided by their doctor; however, one in three (29.8%) were not informed about possible side effects, and a quarter (24.6%) only found out about osteonecrosis of the jaw through their own research. Only half (45.7%) were asked about risk factors, and most information materials were rated poorly. The diagnosis took an average of 18.7 months, with many (47.8%) consulting a doctor only when they experienced pain. Quality of life was severely impaired, with daily pain, physical limitations, and negative effects on mental health. About a third (35.3%) reported that their quality of life had deteriorated significantly.ConclusionsFurther research into patient education is necessary. Web‐based information brochures, improved follow‐up care, and close cooperation with dentists are required. The use of a running sheet, such as the AGSMO running sheet, for individual risk assessment of osteonecrosis of the jaw is recommended. Patients undergoing treatment with bone‐stabilizing medication should be monitored closely. Education about osteonecrosis of the jaw must be continued, and the medical profession must be confronted with it.
Genetic variation and population structure of the rice accessions maintained in the AfricaRice genebank using DArTseq
Authors: Gouda Arnaud Comlan , Sangare Jean Rodrigue , Gnikoua Karlin , Wambugu Peterson , Huggins Trevis D. , Ndjiondjop Marie Noelle 
Published: November 2024

AbstractUtilizing the full potential of rice collections mainly depends on an in‐depth exploration and understanding of the vast diversity in its germplasm. The AfricaRice genebank holds the largest collection of rice germplasm originating from the African continent. In the present study, we comprehensively characterized a collection of 9013 accessions, including Oryza barthii A. Chev., Oryza glaberrima Steud., Oryza longistaminata A. Chev. & Roehr., Oryza sativa L. ssp. indica, and Oryza sativa L. ssp. japonica, for genetic diversity and population structure using genotyping‐by‐sequencing through DArTseq analysis. We identified 27,718 high‐quality single nucleotide polymorphism markers after the genotypic data were filtered. Based on the analyses, the collection has extensive genetic diversity, and the average genetic distance of the entire set was 0.267 (range 0.001–0.469), with 45.1% of pairs of accessions being highly distant and 40.1% moderately distant from each other. Neighbor‐joining tree, principal component, and Bayesian population structure analyses clustered the 9013 accessions into six groups, based roughly on their taxonomic and biological status. The first, second, and third groups consisted of accessions belonging to O. glaberrima, O. barthii, and O. longistaminata, respectively. The fourth, fifth, and sixth groups were improved‐indica, japonica, and traditional‐indica accessions, respectively. The highest value of genetic variance proportion (PhiPT) was found in the species group followed by groups based on cluster analysis and on Bayesian population structure at K = 6. These results allow us to better understand the genetic diversity present in 9013 rice accessions maintained in the AfricaRice genebank and offer a valuable tool for pre breeding, breeding, and further genetic applications.