bluuebunny/crossref_metadata_2025_split huggingface dataset:
Architecture and subunit arrangement of the complete Saccharomyces cerevisiae COMPASS complex
Authors: Wang Yanxing , Ding Zhanyu , Liu Xiangyang , Bao Yu , Huang Min , Wong Catherine C. L. , Hong Xiaoyu , Cong Yao 
Published: November 2018

AbstractMethylation of histone H3 lysine 4 (H3K4) is catalyzed by the multi-component COMPASS or COMPASS-like complex, which is highly conserved from yeast to human, and plays essential roles in gene expression and transcription, cell cycle progression, and DNA repair. Here we present a cryo-EM map of the complete S. cerevisiae COMPASS complex. Through tag or Fab labeling strategy combined with cryo-EM 3D reconstruction and cross-linking and mass spectrometry (XL-MS) analysis, we uncovered new information on the subunit arrangement: Cps50, Cps35, and Cps30 were determined to group together to form the face region in the head of the complex, and Cps40 and the N-terminal portion of Set1 reside on the top of the head. Our map reveals the location of the active center and a canyon in the back of the head. Together, our study provides the first snapshot of the complete architecture of yeast COMPASS and a picture of its subunit interaction network, which could facilitate our understanding of the COMPASS machinery and its functionality.
Comparative assessment shows the reliability of chloroplast genome assembly using RNA-seq
Authors: Osuna-Mascaró Carolina , Rubio de Casas Rafael , Perfectti Francisco 
Published: November 2018

AbstractChloroplast genomes (cp genomes) are widely used in comparative genomics, population genetics, and phylogenetic studies. Obtaining chloroplast genomes from RNA-Seq data seems feasible due to the almost full transcription of cpDNA. However, the reliability of chloroplast genomes assembled from RNA-Seq instead of genomic DNA libraries remains to be thoroughly verified. In this study, we assembled chloroplast genomes for three Erysimum (Brassicaceae) species from three RNA-Seq replicas and from one genomic library of each species, using a streamlined bioinformatics protocol. We compared these assembled genomes, confirming that assembled cp genomes from RNA-Seq data were highly similar to each other and to those from genomic libraries in terms of overall structure, size, and composition. Although post-transcriptional modifications, such as RNA-editing, may introduce variations in the RNA-seq data, the assembly of cp genomes from RNA-seq appeared to be reliable. Moreover, RNA-Seq assembly was less sensitive to sources of error such as the recovery of nuclear plastid DNAs (NUPTs). Although some precautions should be taken when producing reference genomes in non-model plants, we conclude that assembling cp genomes from RNA-Seq data is a fast, accurate, and reliable strategy.
PT symmetry protected non-Hermitian topological systems
Authors: Yuce C. , Oztas Z. 
Published: November 2018

AbstractWe study PT symmetry protected topological phase in non-Hermitian 1D and 2D systems. We show that topological phase exist in non-Hermitian PT symmetric systems for both gapped and gapless systems and discuss appearance of exceptional points. We apply our formalism to a complex extension of the SSH model, topological semimetals and nodal superconductors.
Dual‐mode charge pump with second‐harmonic readout for antenna alignment in wireless power transfer system
Authors: Zhang Hao , Guo Yong‐Xin , Wu Wen 
Published: November 2018

A charge pump is presented by integrating two identical voltage doublers and a modified rat‐race coupler to enable its dual‐mode operations: radio‐frequency (RF)‐to‐direct current (dc) power conversion and second‐harmonic readout. Due to the property of the modified rat‐race coupler, it is able to differentially divide incident RF signals for successive voltage doublers’ high‐efficiency rectification, and couple second harmonics for readout in two highly isolated channels. Output dc voltages are combined in parallel on a single load resistance for more practicality. Experimental validations are demonstrated by both simulation and measurement with a maximum RF‐to‐dc power conversion efficiency of 71.3% and −14.2 dBm second‐harmonic generation with an incident signal power of 19 dBm. This dual‐mode charge pump brings a prospect for antenna alignment in the wireless power transfer system by further exploiting second harmonics.
Fully‐differential second‐order tunable bandstop filter based on source follower
Authors: Almutairi F.T. , Karsilayan A.I. 
Published: November 2018

A new design method for a second‐order bandstop filter is presented. The proposed filter is based on the source follower configuration with a partial positive feedback. The positive feedback is used to increase the quality factor of the filter, and the feed‐forward paths are used to create complex zeros. The proposed bandstop filter has electronically tunable centre frequency, bandwidth and attenuation with low power consumption. The proposed design has been simulated in TSMC 180 nm CMOS technology. The filter achieves input‐referred noise density. For a 2 GHz input signal, the filter achieves a signal‐to‐noise ratio of 60 dB for 238 input signal amplitude. The simulated results show that the centre frequency tuning range is between 1.6 and 3 GHz and the bandwidth is tunable from 0.6 to 1 GHz. The filter consumes about 2.5 mW for a supply voltage of 1.8 V at a centre frequency of 2.3 GHz.
Rotor optimisation design and performance comparison of BDFG for wind power generation
Authors: Zhang Fengge , Wang Hao , Yu Siyang , Ma Dandan 
Published: November 2018

Doubly fed induction generators and permanent magnet synchronous generators are widely used in wind power generation system in recent years. However, they still have technological and economic penalties, which limit their applications in wind power generation. This study presents a novel brushless doubly fed generator (BDFG) with the hybrid rotor, which has several outstanding advantages, so as to penetrate into large‐scale offshore wind power generation. In this study, the magnetic field modulation of the hybrid rotor is studied in detail. Owing to the decisive role of ‘special rotor’ on the performance of BDFG, the effect of main rotor structure parameters on coupling capacity is analysed based on Taguchi method, and the effect of assisted cage bars on the coupling capacity is also researched. The simulation models are simulated and analysed to compare the different exciting winding conditions. A 25.8 kW, 8/4 pole prototype BDFG with the hybrid rotor is manufactured to examine the performance of the proposed BDFG. Finally, the simulation and experiment results verify that the optimised rotor has stronger coupling capacity and the few‐pole (i.e. 4‐pole) winding should be used as control winding.
Multi‐channel VSI fed large variable speed asynchronous hydro‐condenser: fault analysis, fault diagnosis and fault tolerant control
Authors: Joseph Anto , Chelliah Thanga Raj , Lee Kyo‐Beum 
Published: November 2018

Multi‐level voltage source inverter (VSI) fed doubly fed induction machine (DFIM) has gained prominence in large rated hydro‐generating unit (HU) since it provides part load operation with reduced power converter rating and high dynamic stability. Power converters connected in rotor side control real and reactive power of the unit. This study discusses the condenser operation of variable speed HU (250 MW), to be commissioned in Tehri plant (India), with the power flow diagram. Further, it provides dynamic behaviour and survivability status of the DFIM unit during power converter and control circuit faults where power converter redundancy is not available in large rated DFIM unit. Economic analysis of 250 MW HU under power converter and control circuit failures are also investigated. The present work also explores fault tolerant operation of a 250 MW DFIM unit at open switch fault in converters to increase the continuity of the unit operation which provides additional 2% of reactive power support to the grid compared to the DFIM without power converter redundancy operation. Open switch fault is detected through Park's vector phase currents technique and variation in DC link voltage. The computer simulation results are validated in an experiment carried on 2.2 kW DFIM in the laboratory.
Effect of temperature on the dielectric properties of hydrofluoroethers and fluorinated ketone
Authors: Wu Sijun , Chippendale Richard D. , Lewin Paul L. , Hemrle Jaroslav , Kaufmann Lilian 
Published: November 2018

The AC and DC dielectric properties of hydrofluoroethers (HFE) [C3F7OCH3] and fluorinated ketone (FK) [C2F5C(O)CF(CF3)2] have been characterised by dielectric spectroscopy and DC conductivity at different temperatures. Results show that DC conductivity and imaginary permittivity of both fluids are positively correlated with increasing temperature. However, the real permittivity decreases with increasing temperature. The breakdown voltages of HFE and FK at 295 K are ∼10 kV mm−1. Reducing temperature is an effective method to increase the breakdown voltage of the FK coolant, but the breakdown voltage of HFE is less temperature dependent. Finally, as expected repeated breakdown had no significant effect on the AC dielectric strength of both liquids.
Subjektive Gesundheit und Erwerbslosigkeit in Deutschland auf Basis der EU-SILC-Daten von 2005 bis 2014
Authors: Hollederer Alfons , Wildner Manfred 
Published: November 2018

Zusammenfassung
Hintergrund Die Untersuchung zielt darauf, den subjektiven Gesundheitszustand und chronische Gesundheitseinschränkungen in der Erwerbsbevölkerung zu untersuchen und Disparitäten zwischen sozialen Gruppen zu explorieren.
Methodik Der EU-SILC-Survey wird als Haushaltsbefragung seit dem Jahr 2005 in Deutschland jährlich durchgeführt. Die Erhebung umfasste in Deutschland im EU-SILC 2014 eine Zufallsstichprobe von 22 695 Personen ab 16 Jahren (darunter 860 Erwerbslose und 11 390 Erwerbstätige).
Ergebnisse Nach den EU-SILC-Surveys 2005–2014 verbesserte sich die subjektive Gesundheit in der Bevölkerung in Deutschland. 65,2% der Befragten im Alter ab 16 Jahren berichteten eine sehr gute oder gute Gesundheit trotz zunehmender Alterung der Bevölkerung in 2014 (vs. 60,7% in 2005). Die gesundheitliche Ungleichheit stieg zwischen den Erwerbsstatusgruppen jedoch an. Von den Erwerbslosen bewerteten nur 37,2% ihre Gesundheit als sehr gut oder gut in 2014, während bei den Erwerbstätigen dieser Anteil mit 77,1% erheblich höher lag (53,8 vs. 73,2% in 2005). Multivariate logistische Regressionsanalysen für den EU-SILC-Survey 2014 ergeben starke Assoziationen bei selbstbewerteten Gesundheitszustand und chronische Gesundheitseinschränkungen mit Alter und sozialen Determinanten. In der Querschnittsbetrachtung haben Erwerbslose im Vergleich zu Erwerbstätigen eine wesentlich geringere Chance auf einen sehr guten oder guten Gesundheitszustand (OR=0,26) und eine höhere Auftrittswahrscheinlichkeit von chronischen Gesundheitseinschränkungen (OR=3,99) bei Adjustierung von sozio-demografischen Merkmalen. Die Zunahme des Nettoäquivalenzeinkommens und des Bildungsniveaus geht mit verbesserten Gesundheitsprognosen und reduzierten Risiken für chronische Gesundheitseinschränkungen einher. 78,8% der Befragten im höchsten Quintil beim Nettoäquivalenzeinkommens berichteten einen sehr guten oder guten Gesundheitszustand im Gegensatz zu 51,7% im niedrigsten Einkommens-Quintil (OR=2,53). Die Angehörigen von armutsgefährdeten Haushalten geben im Durchschnitt eine schlechtere Gesundheit in allen untersuchten Altersgruppen an. Hoher Bildungsabschluss ist mit besserem subjektivem Gesundheitszustand assoziiert (OR=1,78).
Diskussion Der EU-SILC Survey zeigt zum einen positive Gesundheitsentwicklungen und zum anderen gesundheitliche Ungleichheiten in Deutschland auf. Der EU-SILC-Survey eignet sich als jährliche Wiederholungsbefragung für ein Monitoring von Public Health-Zielen und der Reduktion gesundheitlicher Ungleichheit.
Surgical Strategy in Large Vestibular Schwannoma
Authors: Klironomos Georgios , Dehdashti Amir Reza 
Published: November 2018

Particular care to facial nerve function preservation should be the ultimate goal in surgery for large vestibular schwannomas. We present a 60-year-old patient who presented with an enlarging right vestibular schwannoma and nonserviceable hearing. The patient was operated in the semisitting position after a patent foramen ovale was ruled out. During the positioning, the feet were positioned at the level of the heart. Precordial Doppler was used to monitor for air embolism. Straight skin incision and retrosigmoid craniotomy was performed. Specific attention to venous bleeding was made during the approach. Meticulous arachnoid dissection of the capsule preserving the arachnoid plane at the surface of the brain stem and the facial nerve can be achieved more efficiently with the patient in the semisiting position and with bimanual microdissection technique. After drilling of the internal auditory canal (IAC), we were able to achieve near total removal of the tumor, leaving a tiny tumor carpet due to extreme adherence to the nerve. Water-tight dura closure and replacement of the bone flap was performed. The patient woke up with a House–Brackmann grade III facial weakness which improved to grade I at 6 weeks postoperatively. Postoperative magnetic resonance imaging (MRI) showed a tiny residual at the surface of the facial nerve at the entrance of the IAC. Near total (> 98%) resection of large vestibular schwannomas is an acceptable surgical strategy with excellent facial nerve outcome. With appropriate patient positioning in semisitting and proper anesthesiological and surgical management, the risk of air embolism is negligible.The link to video can be found at: https://youtu.be/ErG9VexbiGw.
Functioning Pituitary Adenoma with Xanthogranulomatous Features: Review of Literature and Case Report
Authors: Vasquez Ciro A. , Downes Angela , Kleinschmidt-DeMasters Bette K. , Youssef A Samy 
Published: November 2018

Abstract
Objectives We present a patient with a prolactin-secreting adenoma with extensive secondary, noninfectious, xanthogranulomatous changes due to remote intratumoral bleeding and provide a literature review of xanthogranulomas (XGs) of the sellar region with emphasis on prolactinomas with xanthogranulomatous features.
Design Case report, with PubMed search of cases of sellar XG, focusing on neuroimaging and surgical approach.
Results A 35-year-old male was found to have a large sellar/suprasellar calcified/cystic mass. Endoscopic transsphenoidal approach for extradural resection was performed and diagnosis made. Review generated 31 patients with the diagnosis of sellar XG. In a minority (6 patients), the underlying lesion for the XG was a pituitary adenoma. Headache was the most common presenting symptom and panhypopituitarism the most common endocrinological abnormality. Examples of hyperprolactinemia associated with sellar XG are also uncommon and due to stalk effect. Neuroimaging of XG on T1-weighted magnetic resonance imaging (MRIs) showed 18 cases (56.3%) were hyperintense, 1 case (3.13%) was isointense, 4 (12.5%) had mixed-signal intensity, and 2 (6.25%) were hypointense. On T2-weighted MRIs, five lesions (15.6%) were hyperintense, three (9.38%) were isointense, nine (28.1%) were heterogeneous, and nine (28.1%) were hypointense. Only one case (3.1%) had calcifications on computed tomography scan similar to ours. In 14 cases (43.7%), the lesions enhanced with contrast administration on MRI.
Conclusion Prolactinomas with secondary xanthogranulomatous change represent a rare cause of XG of the sella. With no radiological or clinical signs specific for XG of the sellar region, preoperative diagnosis can be challenging, if not impossible.
Self-Care Support for Patients with Gastrointestinal Cancer: iCancerHealth
Authors: Berry Donna , Blonquist Traci , Nayak Manan , Grenon Nina , Momani Thaer , McCleary Nadine 
Published: November 2018

Background Patient-centered symptom assessment and management tools allow patients to perform self-assessments and engage in self-symptom management. Efficacious tools exist for reducing symptom distress; however, little is known about feature-specific use.
Objectives This article evaluates the feasibility of the iCancerHealth app as an adjunct to usual patient education regarding cancer symptoms and medication management.
Methods We conducted a single-arm, pilot study grounded in the health outcomes model. Our evaluation included (1) enrollment rates, (2) 2-month utilization rates, (3) patient acceptability, and (4) clinician satisfaction with the provider-side application. English-speaking, adult patients receiving care in the gastrointestinal oncology service of a comprehensive cancer center were invited to participate. Research coordinators enrolled consenting participants who had a personal, Internet-connected device; participants registered and used the platform to complete the baseline symptom assessment in clinic. Participants were reminded weekly to use the app and to perform a symptom report 4 to 6 weeks later.
Results A total of 64 patients were approached, of which 57 (89%; 95% exact confidence interval [CI], 79–96%) enrolled. About half were ≥ 60 years old and 40% were women. Fifty-three patients (93%; 95% exact CI, 85–99%) accessed at least one app feature, at least once, from home. The most frequently used (86%) feature was Health Tracker in which participants monitored and reported symptoms; followed by My Inbox (63%) and My Medications features (60%). The mean acceptability score was 24.8 (standard deviation = 4.2), indicating good acceptability. Clinicians reported that the app was most acceptable with regard to facilitating in-person interactions that occurred after app use.
Conclusion In a sample of adults with various stages of gastrointestinal malignancies, the iCancerHealth app was utilized at a high rate. Features that focused on symptoms and medication side effects plus communication with clinicians were used most frequently. This extends our understanding of preferences and specific feature use with patient-centered technologies.
Key Word Use in Letters of Recommendation for Ophthalmology Residency Applicants According to Race, Gender, and Achievements
Authors: Aggarwal Sahil , Grob Seanna , Banerjee Dhruba , Putzel Preston , Tao Jeremiah 
Published: November 2018

Objectives To identify differences in letters of recommendation (LORs) of applicants to a single ophthalmology residency program by gender, race, academic performance, and match outcome.
Design This was a retrospective analysis of LORS for 2,523 applicants (7,569 letters) to the University of California, Irvine ophthalmology residency program from 2011 to 2018.
Methods Programming scripts were employed to determine the number of times 22 key words from four thematic categories (standout words, ability, grindstone, and compassion) appeared in LORs for each applicant. A chi-square test was performed to assess for possible differences in the presence of each key word by the following characteristics: gender, underrepresented minority (URM) status, Alpha Omega Alpha (AOA) membership, the United States Medical Licensing Exam (USMLE) Step 1 score, and match outcome. Linear regressions were created to determine the frequency at which words in each thematic category appeared according to the same baseline characteristics.
Results In the LORs, females were more likely to be described as “empathetic” (p = 0.002), URMs were more likely to be described as “caring” (p = 0.002), high Step 1 scorers (≥240) were more likely to be described as “outstanding” (p = 0.002), and matched students were more likely to be described as “exceptional” (p = 0.001), “outstanding” (p < 0.001), and “superb” (p = 0.001). Standout words appeared more often in the LORs of AOA members, matched candidates, and high Step 1 scorers (p < 0.001 for all comparisons). “Competent” appeared more commonly in LORs for low Step 1 scorers (p < 0.001) and unmatched applicants (p = 0.001).
Conclusion This study identifies differences in LORs by gender, URM status, and achievement including successful ophthalmology residency match. Females and URMs were more likely to be described as “empathetic” and “caring,” respectively; otherwise, we detected no gender or racial disparities in key word use in LORs. Candidates with high USMLE Step 1 scores or AOA membership had a higher frequency of standout words in their LORs. Whether they were truly more qualified in various dimensions or if they benefited from a halo effect bias warrants further investigation. There was a significant difference in the number of standout words in LORs between matched and unmatched applicants, suggesting that key word frequency may be a relevant metric for LOR appraisal.
Individual synaptic vesicles mediate stimulated exocytosis from cochlear inner hair cells
Authors: Grabner Chad Paul , Moser Tobias 
Published: November 2018

SignificanceSynaptic transmission is codetermined by presynaptic and postsynaptic neurons. Therefore, to understand how the inner hair cell (IHC) signals to spiral ganglion neurons at the first synapse in the auditory pathway, here we directly studied individual membrane fusion events by making cell-attached membrane capacitance recordings from IHCs, for which the quantal size is debated. The observed fusion steps in membrane capacitance are consistent with the quantal hypothesis of synaptic transmission in which individual synaptic vesicles undergo exocytosis independently from each other. This finding, in conjunction with previous work, raises the exciting possibility that action potential generation can be triggered by the release of a single vesicle at the IHC synapse.