bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational Analysis Supports IL-17A as a Central Driver of Neutrophil Extracellular Trap–Mediated Injury in Liver Ischemia Reperfusion
Authors: Tohme Samer , Yazdani Hamza O. , Sud Vikas , Loughran Patricia , Huang Hai , Zamora Ruben , Simmons Richard L. , Vodovotz Yoram , Tsung Allan 
Published: November 2018

Abstract
Hepatic ischemia reperfusion (I/R) is a clinically relevant model of acute sterile inflammation leading to a reverberating, self-sustaining inflammatory response with resultant necrosis. We hypothesized that computerized dynamic network analysis (DyNA) of 20 inflammatory mediators could help dissect the sequence of post-I/R mediator interactions that induce injury. Although the majority of measured inflammatory mediators become elevated in the first 24 h, we predicted that only a few would be secreted early in the process and serve as organizational centers of downstream intermediator complexity. In support of this hypothesis, DyNA inferred a central organizing role for IL-17A during the first 3 h of reperfusion. After that, DyNA revealed connections among almost all the inflammatory mediators, representing an ongoing cytokine storm. Blocking IL-17A immediately after reperfusion disassembled the inflammatory networks and protected the liver from injury. Disassembly of the networks was not achieved if IL-17A blockage was delayed two or more hours postreperfusion. Network disassembly was accompanied by decrease in neutrophil infiltration and neutrophil extracellular trap (NET) formation. By contrast, administration of recombinant IL-17A increased neutrophil infiltration, NET formation, and liver necrosis. The administration of DNase, a NET inhibitor, significantly reduced hepatic damage despite prior administration of IL-17A, and DNase also disassembled the inflammatory networks. In vitro, IL-17A was a potent promoter of NET formation. Therefore, computational analysis identified IL-17A’s early, central organizing role in the rapid evolution of a network of inflammatory mediators that induce neutrophil infiltration and NET formation responsible for hepatic damage after liver I/R.
Perceptions of retirement adequacy in Lesotho: Behavioural and socio-economic influences
Authors: Nthebe Tokiso , Reyers Michelle 
Published: November 2018

Orientation: Saving for retirement is complicated for employees because of the complexity of the financial decisions involved. Financial decision-making is believed to be associated with a number of behavioural and socio-economic factors, and these factors may in turn be related to whether employees perceive themselves to be adequately saving for retirement.Research purpose: This study assesses which factors predict whether individuals working in both the financial and non-financial sectors in Lesotho perceive themselves to be adequately preparing for retirement. The main focus is on financial literacy (FL), financial risk tolerance (FRT) and future time perspective (FTP). As a secondary focus, the study looks at the potential differences between two sectors of employees that may be attributed to differing levels of FL.Motivation for the study: This study focuses on Lesotho to provide an African context on retirement saving and hopefully lay the foundation for future research in the field of retirement saving.Research approach/design and method: Data were collected from 200 participants using an online survey at three companies in Lesotho and analysed using bivariate and multivariate techniques, with a linear regression model used in terms of the multivariate analysis.Main findings: This study finds that FL, FRT and FTP are all positively related to perceived retirement adequacy (RA) in the bivariate analysis. In the multivariate analysis, for those working outside the financial sector, objective FL, subjective FL and FTP were positively related to perceived RA, whereas for those in the financial sector, higher levels of FTP, higher household income and being older were all associated with higher levels of perceived RA.Practical/managerial implications: The participants in this study are not representative of the broader Lesotho population; therefore, further research would be required before this conclusion is generalised.Contribution/value-add: These findings provide insights to industry role players about the profile of individuals who are confident about retirement savings and how this contrasts with those who are not confident.
Effect of Tadalafil on Erectile Function in Patients after Robotic-Assisted Radical Prostatectomy with Unilateral or Bilateral Nerve Sparing
Authors: Lee I-Yen , Tung Min-Che , Hsu Chao-Yu , Yin Jue-Hawn , Chang Yu-Kang , Weng Wei-Chun , Huang Li-Hua , Huang Zhon-Min , Yang Cheng-Kuang , Ou Yen-Chuan 
Published: November 2018

Objective:
Erectile dysfunction (ED) is a major complication of radical prostatectomy. Despite advances in surgical techniques, the postoperative continence and potency rates are still not satisfactory. Many studies have reported experiences with penile rehabilitation using tadalafil for patients receiving nerve-sparing robotic-assisted radical prostatectomy, but similar reports are still lacking in Taiwan.

Patients and Methods:
We collected 163 patients that had undergone unilateral or bilateral nerve-sparing robotic-assisted radical prostatectomy from January 2013 to December 2014 in Tungs' Hospital. One month after operation, 5 mg tadalafil once daily was prescribed for 54 patients whose Foley's catheter had been removed and who had ED. We recorded the International Index of Erectile Function (IIEF-5) score at the 12th month after surgery. We defined postsurgery IIEF-5 ≥22 as potency or no ED. We compared the differences in clinical parameters and postsurgery potency rates between patients with or without tadalafil treatment.

Results:
The postsurgery potency rates of those with tadalafil treatment were significantly higher than that of those without tadalafil treatment (55.6% vs. 32.1%) after a 1-year follow-up observation. The mean (standard deviation) of IIEF-5preamong those with and without tadalafil treatment was 21.3 (4.5) and 19.2 (4.2), respectively. There were no significant differences in baseline clinical condition parameters between patients with potency with or without tadalafil treatment. The results indicated that the tadalafil-treated patients had a higher odds ratio (OR) of potency (adjusted OR = 2.58, 95% confidence interval [CI] = 1.28–5.22) than the nontadalafil-treated patients. However, those ≥65 years old were associated with a lower potency rate (adjusted OR = 0.94, 95% CI = 0.89-0.99).

Conclusion:
Starting penile rehabilitation with tadalafil 5 mg daily 1 month after nerve-sparing radical prostatectomy is safe for patients. Patients with mild-to-moderate ED should use tadalafil 5 mg daily after receiving nerve-sparing robotic-assisted laparoscopic prostatectomy due to its significant benefit in erectile function recovery.
Formatos narrativos para la prevención del embarazo. Efecto de la modalidad narrativa en las actitudes de prevención
Authors: González-Cabrera Catalina , Igartua Perosanz Juan-José 
Published: November 2018

Se analiza el efecto en las actitudes, conocimientos, percepciones e intención de conducta de la persuasión narrativa y del nivel de alfabetización mediática en un video creado para prevenir el embarazo adolescente. Método: Las participantes del experimento (N = 220) cumplimentaron un cuestionario pre-test que medía la habilidad crítica para percibir el contenido sexualizado de los medios y las variables dependientes. Un mes después las adolescentes fueron distribuidas aleatoriamente a dos condiciones experimentales: la mitad vio un video narrativo en formato testimonial y la otra mitad un vídeo narrativo en formato dialógico. Luego rellenaron el cuestionario post-test. Resultados: Se observó́ que el nivel de alfabetización mediática moderaba los efectos indirectos del vídeo narrativo testimonial en la percepción de riesgo de vivir situaciones negativas en un embarazo adolescente. Conclusiones: Se discuten los resultados como un avance en el conocimiento de los procesos de la persuasión narrativa en salud.
Surface–atmosphere exchange of inorganic water-soluble gases and associated ions in bulk aerosol above agricultural grassland pre- and postfertilisation
Authors: Ramsay Robbie , Di Marco Chiara F. , Heal Mathew R. , Twigg Marsailidh M. , Cowan Nicholas , Jones Matthew R. , Leeson Sarah R. , Bloss William J. , Kramer Louisa J. , Crilley Leigh , Sörgel Matthias , Andreae Meinrat , Nemitz Eiko 
Published: November 2018

Abstract. The increasing use of intensive agricultural practices can lead to damaging
consequences for the atmosphere through enhanced emissions of air pollutants.
However, there are few direct measurements of the surface–atmosphere exchange
of trace gases and water-soluble aerosols over agricultural grassland,
particularly of reactive nitrogen compounds. In this study, we present
measurements of the concentrations, fluxes and deposition velocities of the
trace gases HCl, HONO, HNO3, SO2 and NH3 as well as their
associated water-soluble aerosol counterparts Cl−, NO2-,
NO3-, SO42- and NH4+ as determined hourly
for 1 month in May–June 2016 over agricultural grassland near Edinburgh,
UK, pre- and postfertilisation. Measurements were made using the Gradient
of Aerosols and Gases Online Registrator (GRAEGOR) wet-chemistry two-point
gradient instrument. Emissions of NH3 peaked at
1460 ngm-2s-1 3 h after fertilisation, with an
emission of HONO peaking at 4.92 ngm-2s-1 occurring 5 h
after fertilisation. Apparent emissions of NO3- aerosol
were observed after fertilisation which, coupled with a divergence of
HNO3 deposition velocity (Vd) from its theoretical maximum
value, suggested the reaction of emitted NH3 with atmospheric
HNO3 to form ammonium nitrate aerosol. The use of the conservative
exchange fluxes of tot-NH4+ and tot-NO3- indicated
net emission of tot-NO3-, implying a ground source of
HNO3 after fertilisation. Daytime concentrations of HONO remained
above the detection limit (30 ng m−3) throughout the campaign,
suggesting a daytime source for HONO at the site. Whilst the mean Vd of
NH4+ was 0.93 mm s−1 in the range expected for the
accumulation mode, the larger average Vd for Cl− (3.65 mm s−1),
NO3- (1.97 mm s−1) and SO42- (1.89 mm s−1) reflected the
contribution of a super-micron fraction and decreased with increasing
PM2.5∕PM10 ratio (a proxy measurement for aerosol size), providing
evidence – although limited by the use of a proxy for aerosol size – of a
size dependence of aerosol deposition velocity for aerosol chemical
compounds, which has been suggested from process-orientated models of aerosol
deposition.
Bipolar carbon and hydrogen isotope constraints on the Holocene methane budget
Authors: Beck Jonas , Bock Michael , Schmitt Jochen , Seth Barbara , Blunier Thomas , Fischer Hubertus 
Published: November 2018

Abstract. Atmospheric methane concentration shows a well-known decrease over the first
half of the Holocene following the Northern Hemisphere summer insolation
before it started to increase again to preindustrial values. There is a
debate about what caused this change in the methane concentration evolution, in
particular, whether an early anthropogenic influence or natural emissions led
to the reversal of the atmospheric CH4 concentration evolution. Here, we
present new methane concentration and stable hydrogen and carbon isotope data
measured on ice core samples from both Greenland and Antarctica over the
Holocene. With the help of a two-box model and the full suite of CH4
parameters, the new data allow us to quantify the total methane emissions in
the Northern Hemisphere and Southern Hemisphere separately as well as their stable isotopic
signatures, while interpretation of isotopic records of only one hemisphere
may lead to erroneous conclusions. For the first half of the Holocene our
results indicate an asynchronous decrease in Northern Hemisphere and Southern Hemisphere
CH4 emissions by more than
30 Tg CH4 yr−1 in total,
accompanied by a drop in the northern carbon isotopic source signature of
about −3 ‰. This cannot be explained by a change in
the source mix alone but requires shifts in the isotopic signature of the
sources themselves caused by changes in the precursor material for the
methane production. In the second half of the Holocene, global CH4
emissions increased by about 30 Tg CH4 yr−1, while
preindustrial isotopic emission signatures remained more or less constant.
However, our results show that this early increase in methane emissions took
place in the Southern Hemisphere, while Northern Hemisphere emissions started
to increase only about 2000 years ago. Accordingly, natural emissions in the
southern tropics appear to be the main cause of the CH4 increase
starting 5000 years before present, not supporting an early anthropogenic influence on the
global methane budget by East Asian land use changes.
Transforming Assessment Feedback Design: Students' Responses to Adaptively-Released Assessment Feedback (ARAF) Strategies
Authors: Northcote Maria , Morton Lindsay , Williams Anthony , Kilgour Peter , Hattingh Sherene 
Published: November 2018

Abstract
The concept of Adaptively-Released Assessment Feedback (ARAF) is relatively new and, to date, has had limited application in the university sector. This article looks at the applications of ARAF into the assessment of courses in three different contexts across multiple disciplines at both undergraduate and postgraduate course levels. The article outlines the ARAF strategies and their potential for promoting a deeper learning process by enhancing student engagement with feedback. Qualitative data from students are utilized to understand student perceptions of ARAF strategies. Students reported that ARAF increased engagement with assessment feedback and, in some cases, provoked deeper reflection and encouraged them to plan their approach to future assessment tasks.
Do Grading Assessment Learning Perceptions Correlate to Post-Graduation Outcomes?
Authors: Blau Gary , Gaffney Mary Anne , Kim YJ , Jarrell Sherry 
Published: November 2018

Abstract
This study's purposes were to further develop reliable grading assessment learning perception (GALP) scales, and investigate their relationships to two distinct self-reported post-graduation outcomes: securing a full-time job versus securing a full-time job consistent with one's major. GALP measures student perceptions that the grading methods used best reflect their course knowledge and skills. Two semesters of senior business undergraduates (Fall 2016, n = 417 and Spring 2017, n = 857) were sampled. Four GALP scales—Individual Engagement, Team-based, Exam-based, and Individual Creative—were identified. Logistic regression analyses showed that beyond internship experience, Individual Creative GALP was significantly related to post-graduation employment. We argue that adding one closed-response item on a university-level teaching evaluation form asking students if the grading methods used in a course best reflected the student's course knowledge and skills would be useful, particularly if followed by an open item, where students could add their thoughts.
Nietzsche's Futurism
Authors: Loeb Paul S. 
Published: November 2018

Abstract
This essay is one of ten contributions to a special editorial feature in The Journal of Nietzsche Studies 49.2 (Autumn 2018), in which authors were invited to address the following questions: What is the future of Nietzsche studies? What are the most pressing questions its scholars should address? What texts and issues demand our urgent attention? And as we turn to these issues, what methodological and interpretive principles should guide us? The editorship hopes this collection will provide a starting point for discussions about the most fruitful directions for Nietzsche scholarship to take and the most promising avenues for building on the best recent work.
Philosophy, Psychology, and Theory
Authors: Reginster Bernard 
Published: November 2018

Abstract
This essay is one of ten contributions to a special editorial feature in The Journal of Nietzsche Studies 49.2 (Autumn 2018), in which authors were invited to address the following questions: What is the future of Nietzsche studies? What are the most pressing questions its scholars should address? What texts and issues demand our urgent attention? And as we turn to these issues, what methodological and interpretive principles should guide us? The editorship hopes this collection will provide a starting point for discussions about the most fruitful directions for Nietzsche scholarship to take and the most promising avenues for building on the best recent work.
Psychological Nihilism, Passions, and Neglected Works: Three Topics for Nietzsche Studies
Authors: Riccardi Mattia 
Published: November 2018

Abstract
This essay is one of ten contributions to a special editorial feature in The Journal of Nietzsche Studies 49.2 (Autumn 2018), in which authors were invited to address the following questions: What is the future of Nietzsche studies? What are the most pressing questions its scholars should address? What texts and issues demand our urgent attention? And as we turn to these issues, what methodological and interpretive principles should guide us? The editorship hopes this collection will provide a starting point for discussions about the most fruitful directions for Nietzsche scholarship to take and the most promising avenues for building on the best recent work.
Representaciones de un mundo complejo: No tinc paraules de Arnal Ballester
Authors: Sánchez Marcos Estrella 
Published: November 2018

This article looks at how two factors come into play in children's books: the assumption of simplicity and the double target-reader. In the first of these, the child is assumed to lack the intellectual maturity of an adult and the topics, motifs and representations must accordingly be simpler. Studies on approaches to reading and reception, however, reveal that children make critical, sophisticated readers. The double target-reader is the child plus the adult who tends to read along when the child is very young. This adult will take on a prominent role in the process of communication that takes place between an author and the two target readers. And the publishing industry, in turn, provides books designed to please that adult, who browses, chooses and buys. All these factors conflict with the child's need to build up his/her symbolic imaginary through complex stories and representations. This raises the question of how today's author-illustrators of children's books can make those layers of depth visible or not, and find devices for showing complex meanings in formats like the picture book. The book "No tinc paraules", by Arnal Ballester is studied in detail: a book in which the illustrator chooses motifs like eroticism, love, and reflections on identity, making the child the principal target reader of a story that the child himself/herself must construct, and allowing the adult to be a companion in this. This book can serve to show how graphic experimentation and ideas can be contained within a single space.
Evolució que el professor de música experimenta en la forma de percebre i categoritzar l’ensenyament de la llengua estrangera durant una experiència d’Aprenentatge integrat de continguts i llengua (AICLE), en anglès
Authors: Corredera Capdevila Anna , Ruiz Lorenzo Bruno 
Published: November 2018

CLIL programmes (Content and Language Integrated Learning) are opening new paths for the improvement of foreign language learning because they offer students the opportunity to use the target language as an approach to new curricular content. Nonetheless, this is not an easy path. One of the biggest obstacles is the worry that content teachers have about the possible negative repercussions these programmes can have on the learning of the curricular content in their area of specialization. Starting from this point, the focus of this study is on the content professor who participated in an experimental music eduacation teaching sequence in English, carried out during one term in the 3rd level (ESO) in a a secondary school in Catalonia. The objective of this study was to reconstruct, through various interviews and working sessions with the teacher, the evolution of the perspectives and categorizations of the content teacher concerning the CLIL class, in particular in the way the students worked towards the goals of the class. Conversation analysis and complementary ethnographic data indicate a constructive change in the way the teacher categorises and assesses the CLIL programme along with a positive evolution of the organization of the activities of teahcing-learning of the content. The process of collaborative research led to a process of shared reflection about teaching practice between the foreign language specialist and music education specialist, resulting in mutual learning.
Pacing and time allocation at the micro- and meso-level within the class hour: Why pacing is important, how to study it, and what it implies for individual lesson planning
Authors: Goldsmith Joshua 
Published: November 2018

The topic of pacing at the level of the individual class hour has received relatively little coverage in research literature. In order to provide a research-based take on the issue, the current work surveys the existing literature, develops terminology and draws a key distinction between macro-, meso-, and micro-levels of pacing, sequencing, grading, and transitioning. In order to focus on one of pacing’s constituent sub-topics—the allocation of classroom time—this article presents a case study of a first semester college-level introductory German class at a top-tier American university. The data come from two hours of class, one each from the beginning and end of the semester, in an attempt to discover not only how pacing affects teaching synchronically but also how it might change diachronically. Utterances and gestures were transcribed in order to segment the class into activities and sub-activities, and a model for using verbal and gestural cues to perform this kind of segmentation is proposed. The paper also discusses how the teacher allocates time to different kinds of activities, considering pacing strategies that help keep students focused and “on plan” and how these pacing strategies can allow for more time and activities spent on communicative, pair-based work. It is argued that because of the case study teacher’s focus on pacing and use of various strategies to pace the class, not only researchers but also teachers might be able to generalize the micro- and meso-pacing model described in this study to the pacing of individual lessons in their own classrooms.
First-year students' conflicts during their construction of an academic identity in English as a foreign language: Implementing Cultural-Historical Activity Theory
Authors: Oliva-Girbau Angels 
Published: November 2018

This paper constructs a theoretical framework that views academic writing from a context-based perspective. The shift from text to context results from implementating the concept of activity system into the academic community, envisioning academia as the sum of the interactions among its components (users, tools, goals and results), which was applied into an instrumental English course for first-year students through reflective activities that promoted awareness and discussion of the components of the academic community during students' inititiation. We analyse the results of the first one of these activities, a questionnaire students answered as part of the classwork. Their replies to this questionnaire show lack of awareness of the components of the academic activity system, one of the sources of the conflicts they experience during their initiation into the academy. Finally, we suggest a new approach to writing instruction that involves the convergence of research and instruction.