bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights about the formation of a complex impact structure formed in basalt from numerical modeling: The Vista Alegre structure, southern Brazil
Authors: Vasconcelos Marcos Alberto Rodrigues , Rocha Fernanda Farias , Crósta Alvaro Penteado , Wünnemann Kai , Güldemeister Nicole , Leite Emilson Pereira , Ferreira Júlio César , Reimold Wolf Uwe 
Published: May 2019

AbstractWe present the outcomes of simulations of the formation of the Vista Alegre impact structure, Paraná Basin, Brazil. The target comprised a thick sequence of volcanic rocks of predominantly basaltic composition of the Serra Geral Formation that had been deposited on top of sedimentary rocks (sandstones) of the Pirambóia/Botucatu formations. The cratering process was modeled using the iSALE shock physics code. Our best‐fit model suggests that (1) the crater was originally ~10 km in size; (2) it was formed in ~115 s by a stony projectile of 1000 m in diameter, for an assumed impact velocity of 12 km s−1; (3) target rocks underwent a peak pressure of ~20 GPa, in agreement with previous petrographic investigations of shock deformation. Furthermore, the model points out that the sedimentary strata below the layer of volcanic rocks were raised by ~650 meters at the central part of the crater, which resulted in the current partial exposure of the sandstones at the surface. The outcomes of our modeling suggest that parameters like cohesion and strength of the target rocks, after shock compression, determined the final morphology of the crater, especially the absence of a topographically prominent central peak. Finally, the results of the numerical modeling are roughly in agreement with gravity data over the structure, in particular with respect to the presence of the uplifted sedimentary strata, which are responsible for a low gravity signature at the center of the structure.
The Apostasy of the Church and the Cross of Christ: Hans Urs von Balthasar on the Mystery of the Church as Casta Meretrix
Authors: Lawson Stephen D. 
Published: May 2019

AbstractThe ongoing moral and theological catastrophe of persistent and pervasive clergy sexual abuse across the Catholic Church makes theological reflection on sin in the church essential. This essay has two parts. The first, longer part is a hermeneutical argument. I offer a contextualized interpretation of Hans Urs von Balthasar's 1960 essay “Casta Meretrix,” in which he traced the image of the church as a “chaste harlot” through the Christian tradition. I demonstrate that several recent interpretations of this essay have not penetrated to its radical heart. A close reading of the text reveals that here Balthasar affirmed that the church sins precisely as the church, and not merely as individual members. The motivation for this affirmation was not the empirical failures of individuals, but was properly dogmatic—a necessary implication of christology. In the second and concluding part of the essay, I contend that even though Balthasar's use of the feminized image of the casta meretrix does have significant problems and should not be uncritically adopted today, the underlying theological claim regarding the church as sinner is theologically significant. He affirmed a necessary ecclesiological truth, one that can help the church recover its visibility and better understand its essence in repentance, which is all the more essential in light of the continuing revelations of clergy sexual abuse.
Theorizing the (Anglican) lex orandi: A Theological Account
Authors: Cocksworth Ashley 
Published: May 2019

AbstractThis article investigates the lex orandi, an under‐theorized yet central strand of Anglican theological identity. The aim is to provide some theological grounding to the ‘law of prayer’ and is motivated by the question: what, theologically speaking, does the lex orandi do? The first section explores the historical origins of the lex orandi in the Augustinian tradition and then its reception into mainstream Anglican theology. From there, the second section moves beyond Anglicanism by offering a codification of the various operations of the lex orandi, focusing in particular on its role in correcting, communicating and then complexifying Christian belief. The final section explores in further detail the nature of Christian belief as it is re‐routed through spiritual practice and takes, as a sort of test case, aspects of the doctrine of creation ex nihilo to display the ‘complexifying logic’ of the law of prayer.
Light affects heart rate's 24‐h rhythmicity in intensive care unit patients: an observational study
Authors: Korompeli Anna , Kavrochorianou Nadia , Molcan Lubos , Muurlink Olav , Boutzouka Eleni , Myrianthefs Pavlos , Fildissis Georgios 
Published: May 2019

ABSTRACTBackgroundIntensive care unit (ICU) patients experience two affronts to normal 24‐h rhythms: largely internal events such as medication and external factors such as light, noise and nursing interventions.Aims and objectivesWe investigated the impact of light variance within an ICU on 24‐h rhythmicity of three key physiological parameters: heart rate (HR), mean arterial blood pressure (MAP) and body temperature (BT) in this patient population.DesignPatients were assigned to beds either in the ‘light’ or ‘dark’ side within a single ICU. An actigraph continuously recorded light intensity for a 24–72‐h period.MethodsMeasurements of HR, MAP and BT were recorded every 30 min.ResultsHR, MAP and BT did not follow 24‐h rhythmicity in all patients. Higher light exposure in the Light Side of the ICU (122·3 versus 50·6 lx) was related to higher HR (89·4 versus 79·8 bpm), which may translate to clinically relevant outcomes in a larger sample. Duration of stay, the one clinical outcome measured in this study, showed no significant variation between the groups (p = 0·147).ConclusionsICU patients are exposed to varying light intensities depending on bed positioning relative to natural sunlight, affecting the 24‐h rhythm of HR. Larger, well‐controlled studies also investigating the effect of relevant light intensity are indicated.Relevance to clinical practiceLight is a variable that can be manipulated in the constrained environment of an ICU, thus offering an avenue for relatively unobtrusive interventions.
Drought regimens predict life history strategies in Heliophila
Authors: Monroe J. Grey , Gill Brian , Turner Kathryn G. , McKay John K. 
Published: May 2019

Summary

Explaining variation in life history strategies is an enduring goal of evolutionary biology and ecology. Early theory predicted that for plants, annual and perennial life histories reflect adaptations to environments that experience alternative drought regimens. Nevertheless, empirical support for this hypothesis from comparative analyses remains lacking.

Here, we test classic life history theory in Heliophila L. (Brassicaceae), a diverse genus of flowering plants native to Africa, controlling for phylogeny and integrating 34 yr of satellite‐based drought detection with 2192 herbaria occurrence records.

We find that the common ancestor of these species was likely to be an annual, and that perenniality and annuality have repeatedly evolved, an estimated seven and five times, respectively. By comparing historical drought regimens, we show that annuals rather than perennial species occur in environments where droughts are significantly more frequent. We also find evidence that annual plants adapt to predictable drought regimens by escaping drought‐prone seasons as seeds.

These results yield compelling support for longstanding theoretical predictions by revealing the importance of drought frequency and predictability to explain plant life history. More broadly, this work highlights scalable approaches, integrating herbaria records and remote sensing to address outstanding questions in evolutionary ecology.
Ricoeur’s narrative philosophy: A source of inspiration in critical hermeneutic health research
Authors: Missel Malene , Birkelund Regner 
Published: May 2019

AbstractPatient‐centred care has gained ground in health service following a health policy initiative aimed at changing the paternalistic culture towards one with more patient involvement. Development of knowledge relating to people's lived experiences of illness is important in this context. Literature in the field of health science describes methods for exploring what is at stake for people affected by illness, and the French philosopher Paul Ricoeur has been a significant source of inspiration. Especially, Ricoeur's interpretation theory has been construed and applied in different, often schematic, methodological variations, whereas his narrative philosophy is a little used source of inspiration. Health science has been characterized by a biomedical awareness of method and the idea that there is a direct and immediate path to patients' experiences, a viewpoint that can be traced back to Descartes and the philosophy of subjectivism. Opposed to Descartes, Ricoeur says that we are already embedded in a world of traditions and meanings over which we have no control. According to Ricoeur, we leave traces when we express ourselves, and traces are formed by the world of meanings and traditions to which we belong. Often, the sense in the traces is hidden, making it impossible to directly understand individual's experiences. Reflection on an individual's lived experiences must take place via the narratives in which the individual expresses themselves. The centrepiece of Ricoeur's narrative philosophy is the threefold mimesis, which is an approach to understanding the meaning of peoples' lived experiences. The philosophical hermeneutics of Gadamer plays an important role in Ricoeur's theory of interpretation, although he has criticized Gadamer for failing to include one dimension in his philosophy; he finds this dimension in Habermas' ideology critique. Ricoeur's ideology critique is absent in health science research, which is why it has been made a focal point in this article.
Next‐generation sequencing identified genomic region and diagnostic markers for resistance to bacterial wilt on chromosome B02 in peanut (Arachis hypogaea L.)
Authors: Luo Huaiyong , Pandey Manish K. , Khan Aamir W. , Wu Bei , Guo Jianbin , Ren Xiaoping , Zhou Xiaojing , Chen Yuning , Chen Weigang , Huang Li , Liu Nian , Lei Yong , Liao Boshou , Varshney Rajeev K. , Jiang Huifang 
Published: May 2019

SummaryBacterial wilt, caused by Ralstonia solanacearum, is a devastating disease affecting over 350 plant species. A few peanut cultivars were found to possess stable and durable bacterial wilt resistance (BWR). Genomics‐assisted breeding can accelerate the process of developing resistant cultivars by using diagnostic markers. Here, we deployed sequencing‐based trait mapping approach, QTL‐seq, to discover genomic regions, candidate genes and diagnostic markers for BWR in a recombination inbred line population (195 progenies) of peanut. The QTL‐seq analysis identified one candidate genomic region on chromosome B02 significantly associated with BWR. Mapping of newly developed single nucleotide polymorphism (SNP) markers narrowed down the region to 2.07 Mb and confirmed its major effects and stable expressions across three environments. This candidate genomic region had 49 nonsynonymous SNPs affecting 19 putative candidate genes including seven putative resistance genes (R‐genes). Two diagnostic markers were successfully validated in diverse breeding lines and cultivars and could be deployed in genomics‐assisted breeding of varieties with enhanced BWR.
Geology, Mineralogy, Geochronology, and Sulfur Isotope Constraints on the Genesis of the Luanling Gold Telluride Deposit, Western Henan Province, Central China
Authors: Chao Weiwei , Hayashi Ken‐ichiro , Ye Huishou , Mao Jingwen , Geng Yanguang , Bi Minfeng , Wang Peng , Pei Qiuming 
Published: May 2019

AbstractThe Luanling gold telluride deposit in the Xiong'ershan region is located in the southern margin of the North China Craton. The deposit formed in four stages, that is, an early pyrite‐quartz stage (I), a pyrite‐molybdenite stage (II), a sulfide‐telluride‐gold stage (III), and a late carbonate stage (IV). Six species of telluride in stage (III) are recognized, including hessite, altaite, petzite, unidentified Au‐Ag‐Te mineral, empressite, and unidentified Ag‐Te‐S mineral. Gold occurs mostly as native gold and electrum along the microfractures of sulfides or the contact between sulfide and telluride. The mineralization temperature of stage I and stage III ranges from 296 to 377°C and 241 to 324°C, respectively. Tellurides in stage III precipitate at the logƒS2from −14.3 to −7.3 and logƒTe2from −17.4 to −9.4. The ores were formed in an oxidizing environment. The Re‐Os model ages of molybdenite are 162–164 Ma, which indicate that the main ore formation stage was in the Late Jurassic. The Re contents of five molybdenite samples from the Luanling deposit have a range of 36.32–81.95 ppm, except for one large value of 220 ppm, which indicates that the ore‐forming materials are mainly derived from a crustal‐dominated source. The δ34S values of sulfides range from −17.6 to −6.2‰, whereas those of sulfates are from 6.8 to 11.5‰. The δ34S∑Svalue of the ore‐forming system is 0.0–3.7‰, indicating that the sulfur of the Luanling deposit derived from a deep igneous source. Mineral association and isotope data of the Luanling deposit, together with its geodynamic setting, imply that this deposit belongs to a part of the metallogenic system of the Nannihu‐Sandaozhuang, Shangfangou porphyry molybdenum deposits, and the Late Jurassic granitic intrusions.
Effects of an expanded Uber-like transport system on access to and use of maternal and newborn health services: findings of a prospective cohort study in Homa Bay, Kenya
Authors: Onono Maricianah Atieno , Wahome Samuel , Wekesa Pauline , Adhu Catherine Kidiga , Waguma Lawrence Wandei , Serem Titus , Owenga Mildred Anyango , Ong'wen Patricia 
Published: May 2019

IntroductionKenya’s progress towards reducing maternal and neonatal deaths is at present ‘insufficient’. These deaths could be prevented if the three delays, that is, in deciding to seek healthcare (delay 1), in accessing formal healthcare (delay 2) and in receiving quality healthcare (delay 3), are comprehensively addressed. We designed a mobile phone enhanced 24 hours Uber-like transport navigation system coupled with personalised and interactive gestation-based text messages to address these delays. Our main objective was to evaluate the impact of this intervention on women’s adherence to recommended antenatal (ANC) and postnatal care (PNC) regimes and facility birth.MethodsWe conducted a prospective cohort study. Women were eligible to participate in the study if they were 15 years or older and less than 28 weeks gestation. We defined cases as those who received the standard of care plus the intervention and the control group as those who received the standard of care only. For analysis, we used logistic regression analysis and report crude and adjusted OR (aOR) and 95 % CI.ResultsCases (women who received the intervention) had five times higher odds of having four or more ANC visits (aOR=4.7, 95% CI 3.20 to 7.09), three times higher odds of taking between 30 and 60 min to reach a health facility for delivery (aOR=3.14, 95% CI 2.37 to 4.15) and four times higher odds of undergoing at least four PNC visits (aOR=4.10, 95% CI 3.11 to 5.36).ConclusionAn enhanced community-based Uber-like transport navigation system coupled with personalised and interactive gestation-based text messages significantly increased the utilisation of ANC and PNC services as well as shortened the time taken to reach an appropriate facility for delivery compared with standard care.
CPL effective dark energy from the backreaction effect
Authors: Yao Yan-Hong , Meng Xin-He 
Published: May 2019

In this paper, we interpret the dark energy as an effect caused by small-scale inhomogeneities of the universe with the use of the spatial averaged approach of Buchert [Gen. Relat. Gravit. 32, 105 (2000); 33, 1381 (2001)]. The model considered here adopts the Chevallier–Polarski–Linder (CPL) parametrizations of the equation of state of the effective perfect fluid from the backreaction effect. Thanks to the effective geometry introduced by Larena et al. [Phys. Rev. D 79, 083011 (2009)] in their previous work, we confront such backreaction model with the latest type Ia supernova and Hubble parameter observations, coming out with the results that reveal the difference between the Friedmann–Lemaître–Robertson–Walker model and backreaction model.
The Metabolic Basis of Kidney Cancer
Authors: Linehan W. Marston , Schmidt Laura S. , Crooks Daniel R. , Wei Darmood , Srinivasan Ramaprasad , Lang Martin , Ricketts Christopher J. 
Published: May 2019

Abstract

Kidney cancer is not a single disease but represents several distinct types of cancer that have defining histologies and genetic alterations and that follow different clinical courses and have different responses to therapy. Mutation of genes associated with kidney cancer, such as VHL, FLCN, TFE3, FH, or SDHB, dysregulates the tumor's responses to changes in oxygen, iron, nutrient, or energy levels. The identification of these varying genetic bases of kidney cancer has increased our understanding of the biology of this cancer, allowing the development of targeted therapies and the appreciation that it is a cancer driven by metabolic alterations.

Significance:
Kidney cancer is a complex disease composed of different types of cancer that present with different histologies, clinical courses, genetic changes, and responses to therapy. This review describes the known genetic changes within kidney cancer, how they alter tumor metabolism, and how these metabolic changes can be therapeutically targeted.
A Gene Signature Predicting Natural Killer Cell Infiltration and Improved Survival in Melanoma Patients
Authors: Cursons Joseph , Souza-Fonseca-Guimaraes Fernando , Foroutan Momeneh , Anderson Ashley , Hollande Frédéric , Hediyeh-Zadeh Soroor , Behren Andreas , Huntington Nicholas D. , Davis Melissa J. 
Published: May 2019

Abstract
Natural killer (NK) cell activity is essential for initiating antitumor responses and may be linked to immunotherapy success. NK cells and other innate immune components could be exploitable for cancer treatment, which drives the need for tools and methods that identify therapeutic avenues. Here, we extend our gene-set scoring method singscore to investigate NK cell infiltration by applying RNA-seq analysis to samples from bulk tumors. Computational methods have been developed for the deconvolution of immune cell types within solid tumors. We have taken the NK cell gene signatures from several such tools, then curated the gene list using a comparative analysis of tumors and immune cell types. Using a gene-set scoring method to investigate RNA-seq data from The Cancer Genome Atlas (TCGA), we show that patients with metastatic cutaneous melanoma have an improved survival rate if their tumor shows evidence of NK cell infiltration. Furthermore, these survival effects are enhanced in tumors that show higher expression of genes that encode NK cell stimuli such as the cytokine IL15. Using this signature, we then examine transcriptomic data to identify tumor and stromal components that may influence the penetrance of NK cells into solid tumors. Our results provide evidence that NK cells play a role in the regulation of human tumors and highlight potential survival effects associated with increased NK cell activity. Our computational analysis identifies putative gene targets that may be of therapeutic value for boosting NK cell antitumor immunity.
The Impact of High-Dose Glucocorticoids on the Outcome of Immune-Checkpoint Inhibitor–Related Thyroid Disorders
Authors: Ma Chanjuan , Hodi F. Stephen , Giobbie-Hurder Anita , Wang Xiaocheng , Zhou Jing , Zhang Amy , Zhou Ying , Mao Fei , Angell Trevor E. , Andrews Chelsea P. , Hu Jiani , Barroso-Sousa Romualdo , Kaiser Ursula B. , Tolaney Sara M. , Min Le 
Published: May 2019

Abstract
Thyroid disorders have emerged as one of the most common immune-related adverse events (irAE), yet optimum management and biomarkers to predict vulnerable individuals remain to be explored. High-dose glucocorticoid (HDG) therapy is routinely recommended for irAEs. However, systematic analysis of the impact of glucocorticoid therapy on the outcome of immune-checkpoint inhibitor (ICI)–induced thyroid disorders is lacking. We analyzed 151 patients with or without ICI-related thyroid disorders. We divided the patients with ICI-related thyroid disorders into two subgroups: those with and without HDG treatment. Our results showed no significant differences between HDG and no HDG groups in terms of the median duration of thyrotoxicosis: 28 (range, 7–85) and 42 (range, 14–273) days, the median time to conversion from thyrotoxicosis to hypothyroidism: 39 days (range, 14–169) and 42 days (range, 14–315) days, the median time to onset of hypothyroidism: 63 (range, 21–190) and 63 (range, 14–489) days, and the median maintenance dose of levothyroxine: 1.5 (range, 0.4–2.3) μg/kg/day, and 1.3 (range, 0.3–2.5) μg/kg/day. The median pretreatment TSH was 2.3 (range, 0.3–5.2) mIU/L and 1.7 (range, 0.5–4.5) mIU/L in patients with and without ICI-related thyroid disorders, respectively. Baseline TSH was significantly higher in patients who developed ICI-related thyroid disorders (P = 0.05). Subgroup analysis revealed significantly higher baseline TSH in male but not in female patients with ICI-induced thyroid dysfunction. Our results show that HDG treatment did not improve the outcome of ICI-related thyroid disorders.
The Psalmic Oral Formula Revisited: A Cognitive-Performative Approach
Authors: Coleman Stephen 
Published: May 2019

Abstract
In the wake of Milman Parry’s and Alfred Lord’s groundbreaking discovery of oral composition in Homeric epics, biblical scholars analyzed the formulaic language of the biblical Psalms with a view toward establishing a similar compositional function. This approach met with little success. Among the many recent refinements to the Oral-Formulaic theory is the distinction between oral composition and oral conception, a distinction which allows for identifying oral features of a “text” which do not necessarily reflect composition in performance. The goal of this article is two-fold. First this article proposes a new model for identifying oral formulas based on the theory of prototypical categorization developed within the field of cognitive sciences, particularly cognitive linguistics. Second, this article argues that the psalmic oral formulas are best understood as linguistic registers which evoke a performance arena, a feature of orally derived literature described most extensively by John Miles Foley.
Making a Home for Refugees: Jürgen Moltmann’s Trinitarian Theology and Hospitality
Authors: Redick Caroline 
Published: May 2019

Abstract
This article seeks to offer a theological response for the ongoing Syrian refugee crisis (2011–19) by examining the doctrine of the Trinity in light of the contemporary landscape of displacement. In order to explore divine identity in relation to displacement and hospitality, the theology of Jürgen Moltmann will be utilized in order to interpret the current crisis through the lens of Trinitarian salvation. Moltmann’s understanding of Trinitarian persons as spaces will be explored to highlight the role of risk in love and to illustrate how salvific enfolding even embraces the possibility of harm. Finally, building from his theology, the article will argue that this understanding of Trinitarian salvation impacts a Christian ethic of hospitality during the refugee crisis.