bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybridization potential between the rubber dandelion Taraxacum kok‐saghyz and common dandelion Taraxacum officinale
Authors: Iaffaldano Brian , Cardina John , Cornish Katrina 
Published: February 2018

AbstractTaraxacum kok‐saghyz (TK) is a species of dandelion that is of interest commercially for the high‐quality rubber produced in its roots; however, TK competes poorly with weeds. In order to overcome this shortcoming, there is interest in developing herbicide‐resistant TK germplasm by a variety of means, including selection, transgene insertion, and gene editing. The potential release of such germplasm raises the question of gene flow between TK and its ubiquitous weedy relative, the common dandelion, Taraxacum officinale (TO). The potential for introgression may be influenced by the reproductive biology of TO, which can exist as a diploid sexual or polyploid obligate apomict. In North America, only polyploid, apomictic TO has been described. As weedy TO types exhibit obligate apomixis, they are expected to be unreceptive to TK pollen; however, it may still be possible for them to pollinate TK. To this end, unidirectional crosses were conducted and progeny were evaluated with molecular markers. Taraxacum officinale pollen used to fertilize TK flowers produced low seed set and seeds with a low germination rate. However, 23% of rare viable progeny proved to be the result of true hybridization. Outdoor TK seed production areas heavily contaminated with TO were also screened for naturally occurring hybridization during a three‐year period using a combined strategy of both phenotyping (~3.35 million plants) and genotyping. Hybrids were detected during one of these years, at a rate of 1 in 100,000, when pollination was augmented with beehives. Hybrids from controlled crosses exhibited TO characteristics, such as lacerate leaves and apomixis. Some apomictic hybrids were able to produce viable seeds, whereas non‐apomicts were sterile. Seeds produced by apomictic hybrids demonstrated the ability to establish and produce apomictic progeny when in competition with perennial ryegrass. The prevalence of apomixis in TO may limit subsequent pollen‐mediated gene flow and introgression, but more work is needed to understand the longevity of apomictic hybrids under natural conditions.
Molecular imprinted polymers based on magnetic chitosan with different deep eutectic solvent monomers for the selective separation of catechins in black tea
Authors: Ma Wanwan , Dai Yunliang , Row Kyung Ho 
Published: February 2018

AbstractTwo types of molecular‐imprinted polymers‐based magnetic chitosan with facile deep eutectic solvent‐functional monomers (Fe3O4‐CTS@DES‐MIPs) were synthesized and applied as adsorbents in magnetic solid‐phase extraction (MSPE) for the selective recognition and separation of (+)‐catechin, (−)‐epicatechin, and (−)‐epigallocatechin gallate in black tea. The obtained Fe3O4‐CTS@DES‐MIPs were characterized by Fourier transform infrared spectroscopy and field emission scanning electron microscopy. The selective recognition ability was examined by adsorption experiments. The actual amounts of (+)‐catechin, (−)‐epicatechin, and (−)‐epigallocatechin gallate extracted from black tea using Fe3O4‐CTS@DES‐MIPs by the MSPE method were 13.10, 6.32, and 8.76 mg/g, respectively. In addition, the magnetic Fe3O4‐CTS@DES‐MIPs showed outstanding recognition and selectivity. Therefore, it can be used to separate bioactive compounds from black tea. The new‐type of DES adopted as the functional monomer in this paper provides a new perspective for the recognition and separation of bioactive compounds.
Patterns of care and outcomes of adjuvant therapy for high‐risk head and neck cancer after surgery
Authors: Osborn Virginia Wedell , Givi Babak , Rineer Justin , Roden Dylan , Sheth Niki , Lederman Ariel , Katsoulakis Evangelia , Hu Kenneth , Schreiber David 
Published: February 2018

AbstractBackgroundPostoperative chemoradiotherapy (CRT) is considered standard of care in patients with locally advanced head and neck cancer with positive margins and/or extracapsular extension (ECE).MethodsThe National Cancer Data Base (NCDB) was queried to identify patients with squamous cell carcinoma of the head and neck with stages III to IVB disease or with positive margins and/or ECE diagnosed between 2004 and 2012 receiving postoperative radiotherapy (RT). Using univariable and multivariable logistic and Cox regression, we assessed for predictors of CRT use and covariables impacting overall survival (OS), including in a propensity‐matched subset.ResultsOf 12 224 patients, 67.1% with positive margins and/or ECE received CRT as well as 54.0% without positive margins and/or ECE. The 5‐year OS was 61.6% for RT alone versus 67.4% for CRT. In the propensity‐matched cohort, OS benefit persisted with CRT, including in a subset with positive margins and/or ECE but not without.ConclusionPostoperative CRT seems underutilized with positive margins and/or ECE and overutilized without positive margins and/or ECE. The CRT was associated with improved OS but the benefit persisted only in the subset with positive margins and/or ECE.
A qualitative study of smartwatch usage and its usability
Authors: Chun Jaemin , Dey Anind , Lee Kyungtaek , Kim SeungJun 
Published: February 2018

AbstractThis study aims to explore usability issues of watch‐type wearable devices and to suggest guidelines for improved operation of smartwatches. To do so, we conducted a series of surveys, interviews, and task performance experiments. Thirty smartwatch users from ages 20 to 43 years were recruited. Users’ experiences of smartwatches were collected via a weeklong, online‐based diary study, which consisted of various tasks to be completed while smartwatches were in use. Our study assessed usability problems associated with those tasks, concurrent tasks conducted while interacting with smartwatches, pain points/discomfort that users had while interacting with their devices, and requirements/requests of the smartwatch users. During the week of tracking, participants were asked to complete the usability evaluation three times a day using usability principles we designed for the study: information display, control, learnability, interoperability, and preference. In addition, task performance tests were conducted for the tasks most frequently conducted on touch‐based displays: number entry, swiping, and scrolling. Specific usability issues of smartwatches were identified and summarized for each usability principle by triangulating survey, interview, and task performance evaluation results. Based on the insights from the results of the study, we conclude by suggesting guidelines for further enhancing users’ experience of future smartwatches.
Carfilzomib in relapsed or refractory multiple myeloma patients with early or late relapse following prior therapy: A subgroup analysis of the randomized phase 3 ASPIRE and ENDEAVOR trials
Authors: Mateos Maria‐Victoria , Goldschmidt Hartmut , San‐Miguel Jesus , Mikhael Joseph , DeCosta Lucy , Zhou Lifen , Obreja Mihaela , Blaedel Julie , Szabo Zsolt , Leleu Xavier 
Published: February 2018

AbstractWe performed analyses of the randomized phase 3 ASPIRE and ENDEAVOR trials to investigate the efficacy of carfilzomib among subgroups of relapsed or refractory multiple myeloma patients who had early or late disease relapse following initiation of the immediately prior therapy. In ASPIRE and ENDEAVOR, patients had received 1 to 3 prior lines of therapy. Patients in ASPIRE received carfilzomib, lenalidomide, and dexamethasone (KRd) or lenalidomide and dexamethasone (Rd), and patients in ENDEAVOR received carfilzomib and dexamethasone (Kd) or bortezomib and dexamethasone (Vd). Patients with relapse ≤1 year after initiating the most recent prior line of therapy were categorized as early relapsers, and patients with relapse after >1 year were categorized as late relapsers. The median progression‐free survival (PFS) in ASPIRE for early relapsers was 21.4 months for KRd vs 10.7 months for Rd (hazard ratio [HR]: 0.714; 95% confidence interval [CI]: 0.508–1.004; P = 0.0257), and for late relapsers was 29.7 months for KRd vs 18.2 months for Rd (HR: 0.675; 95% CI: 0.533–0.854; P = 0.0005). The overall response rate (ORR) for early relapsers was 83.2% for KRd vs 54.8% for Rd, and for late relapsers was 89.0% for KRd vs 69.7% for Rd. The median PFS in ENDEAVOR (Kd vs Vd) for early relapsers was 13.9 months vs 5.7 months (HR: 0.598; 95% CI: 0.423–0.846; P = 0.0017), and for late relapsers was 22.2 months vs 10.2 months (HR: 0.486; 95% CI: 0.382–0.620; P < 0.0001). The ORR (Kd vs Vd) for early relapsers was 63.4% vs 49.1% and for late relapsers was 81.8% vs 66.8%. In conclusion, patients with relapsed or refractory multiple myeloma who received carfilzomib‐containing regimens had improved PFS and ORR compared with control groups, regardless of whether they had an early or late relapse following the most recent prior therapy.
Metabolic regulation of leukocyte motility and migration
Authors: Marelli-Berg Federica M , Jangani Maryam 
Published: February 2018

Abstract
Dynamic reorganization of the cytoskeleton is essential for numerous cellular processes including leukocyte migration. This process presents a substantial bioenergetic challenge to migrating cells as actin polymerization is dependent on ATP hydrolysis. Hence, migrating cells must increase ATP production to meet the increased metabolic demands of cytoskeletal reorganization. Despite this long-standing evidence, the metabolic regulation of leukocyte motility and trafficking has only recently begun to be investigated. In this review, we will summarize current knowledge of the crosstalk between cell metabolism and the cytoskeleton in leukocytes, and discuss the concept that leukocyte metabolism may reprogram in response to migratory stimuli and the different environmental cues received during recirculation ultimately regulating leukocyte motility and migration.
Review on regulation of leukocyte migration by metabolic pathways induced by adhesion and chemokine receptors.
Delayed right ventricular perforation complicated by intracardiac thrombosis after implantable cardioverter‐defibrillator implantation
Authors: Ito Tsuyoshi , Goto Toshihiko , Kawada Yu , Ohte Nobuyuki 
Published: February 2018

AbstractCardiac perforation and intracardiac thrombosis are infrequent complications after implantable cardioverter‐defibrillator (ICD) implantation, and a case of lead perforation complicated by thrombosis is extremely rare. We report the case of a 66‐year‐old man with delayed ICD lead perforation concomitant with intracardiac lead thrombosis successfully treated by anticoagulant therapy followed by transvenous lead management.
What factors lead to the acceleration of ventricular tachycardia during antitachycardia pacing?—Results from over 1000 episodes
Authors: Fang Yin , Gu Kai , Yang Bing , Ju Weizhu , Chen Hongwu , Li Mingfang , Liu Hailei , Wang Jiaxian , Yang Gang , Chen Minglong 
Published: February 2018

AbstractIntroductionVentricular tachycardia (VT) acceleration due to antitachycardia pacing (ATP) therapy could be often observed in patients with implantable cardioverter defibrillator (ICD), which usually results in additional shock. However, few studies focused on the risk factors for VT acceleration caused by ATP therapy. The purpose of this study was to investigate risk factors for VT acceleration due to ATP delivery.MethodsWe retrospectively reviewed 1056 ATP episodes in 33 patients with structural heart diseases, of whom clinical characteristics and episodes details were evaluated.ResultsAt individual patient level, number of VT morphologies recorded in electrograms during follow‐up was a risk factor with cutoff point of 1 (AUC 0.79, sensitivity 72.7%, specificity 77.3%, P < .001) to predict ATP acceleration (OR 3.50, P = .008). From episode‐based analysis, VT cycle length (VTCL) and mean variation in VTCL were risk factors to predict ATP acceleration (OR 0.98, P < 0.001 vs OR 1.06, P < .001, respectively), with cutoff points of 347 ms (AUC 0.67, sensitivity 82.5%, specificity 47.6%, P < .001) and 7.3 ms (AUC 0.66, sensitivity 77.5%, specificity 56.7%, P < .001), respectively. In addition, VTs with cycle length less than 347 ms were more likely to be accelerated by burst stimulation with more pulse numbers (OR 3.31, P < .001).ConclusionsNumber of VT morphologies, VTCL, and mean variation in VTCL are risk factors predicting ATP acceleration. Burst stimulation with less pulse numbers should be performed in VTs with cycle length less than 347 ms.
Subcutaneous ICD implantation in a patient with hypertrophic cardiomyopathy after transvenous ICD failure: A case report
Authors: Baroni Matteo , Cattafi Giuseppe , Arupi Michele , Paolucci Marco , Pelenghi Stefano , Lunati Maurizio 
Published: February 2018

AbstractWe describe the case of a patient with hypertrophic cardiomyopathy who experienced the failure of a transvenous implantable cardioverter defibrillator (T‐ICD) lead and the following inability of a second T‐ICD to convert a ventricular fibrillation. A subcutaneous ICD (S‐ICD) was finally implanted and was effective at defibrillation test.
Experience managing pain associated with supraclavicular nerves compressed by a cardiac implantable electrical device, diagnosed by the local nerve block
Authors: Imada Hiroshi , Fukuzawa Koji , Kiuchi Kunihiko , Hirata Ken‐ichi , Sato Hitoaki 
Published: February 2018

AbstractA 72‐year‐old man with ischemic cardiomyopathy was referred to undergo an implantation of a cardiac implantable electrical device (CIED). A pocket was created subcutaneously on the left anterior chest. After the operation, he complained of severe pain irradiating to his left posterior shoulder. The local anesthetic nerve block by a local infusion of mepivacaine revealed the pain was associated with the supraclavicular nerve. We re‐created the pocket and shifted the generator toward the inner side, and the irradiating pain vanished. A local anesthetic supraclavicular nerve block is an important option for the diagnosis of pain after a CIED implantation.
Risk factors and prevention of dabigatran‐related gastrointestinal bleeding in patients with atrial fibrillation
Authors: Nantsupawat Teerapat , Soontrapa Suthipong , Nantsupawat Nopakoon , Sotello David , Klomjit Saranapoom , Adabag Selcuk , Perez‐Verdia Alejandro 
Published: February 2018

AbstractIntroductionDabigatran, as compared with warfarin, was associated with lower rates of stroke and systemic embolism with similar rates of major hemorrhage. But it has a significantly higher risk of gastrointestinal bleeding (GIB). There are limited data on how to prevent GIB from dabigatran and what are the risk factors.MethodsWe performed a retrospective cohort study of patients with atrial fibrillation who have ever taken dabigatran for thromboprophylaxis from October 2010 to February 2013.ResultsA total of 247 patients were identified. There were 10 (4%) patients who developed GIB (6 (6.5%) in PPI/H2RA users vs 4 (2.6%) in non‐PPI/H2RA users; P = .184). History of GIB within 1 year prior to dabigatran initiation and HAS‐BLED score ≥3 are independent risk factors for GIB, with odds ratio of 25.14 (95% CI, 2.85‐221.47; P < .01) and 5.85 (95% CI, 1.31‐26.15; P = .021), respectively.ConclusionIn this real‐world cohort, PPI/H2RA use was not associated with reduced GIB events. HAS‐BLED score ≥3 and prior history of GIB within 1 year are independent risk factors for GIB among dabigatran users.
Comparison of triple‐site ventricular pacing versus conventional cardiac resynchronization therapy in patients with systolic heart failure: A meta‐analysis of randomized and observational studies
Authors: Zhang Baowei , Guo Junfang , Zhang Guohui 
Published: February 2018

AbstractBackgroundConventional cardiac resynchronization therapy (CRT, Bi‐V) is associated with no response in about 40% patients due to an insufficient resynchronization. Some studies showed triple‐site ventricular (Tri‐V) pacing had greater benefits compared with Bi‐V pacing, but the results of these studies were conflicting. We hypothesized that Tri‐V pacing had greater benefits on long‐term outcomes compared with Bi‐V pacing in patients with heart failure.MethodsPubMed, EMBASE, and the Cochrane Library were searched for clinical studies with related outcomes. Weighted mean differences (WMD) and 95% confidence intervals (CIs) were calculated to compare the change in left ventricular ejection fraction (LVEF), left ventricular geometry, functional capacity, and quality of life between Tri‐V pacing group and control group.ResultsFive trials with 251 patients were included in the analysis. Patients in the Tri‐V pacing group had a greater improvement in LVEF (WMD 4.04; 95% CI 2.15‐5.92, P < .001) and NYHA classes (WMD −0.27; 95% CI −0.42 to −0.11, P = .001) compared with control group. However, there were no significant differences in left ventricular geometry, six‐min walk distance, or Minnesota Living With Heart Failure Questionnaire score between the two groups. The subgroup analyses showed there might be a greater improvement in LVEF in the Tri‐V pacing group in patients with QRS duration ≥ 155 ms (WMD 5.60; 95% CI 3.09‐8.10, P < .001).ConclusionsThe present analysis suggests that Tri‐V pacing has greater benefits in terms of an improvement in LVEF and functional capacity in patients with systolic heart failure, especially in patients with the duration of QRS ≥ 155 ms.
Ventricular tachycardia storm originating from interventricular septum successfully treated with surgical cryoablation with electroanatomic and electrophysiological mapping before dual valve replacement
Authors: Kawamura Iwanari , Fukamizu Seiji , Miyazawa Satoshi , Hojo Rintaro , Ito Fusahiko , Watanabe Masazumi , Nishizaki Mitsuhiro , Sakurada Harumizu , Hiraoka Masayasu 
Published: February 2018

AbstractA 58‐year‐old man with dilated cardiomyopathy was admitted with heart failure. He had a history of two catheter ablation procedures for ventricular tachycardia (VT) originating from the intraventricular septum (IVS). Before dual valve replacement (DVR), he suffered a VT storm. An electrophysiological study revealed an extended low‐voltage area at the IVS with the exit of the induced VT at the anterior side. Radiofrequency application was performed at the VT exit as a landmark for surgical cryoablation (SA). During the DVR, SA was performed at the IVS using this landmark. After SA, the patient had no ventricular tachyarrhythmia.
Long‐term outcomes of heart failure patients who received primary prevention implantable cardioverter‐defibrillator: An observational study
Authors: Looi Khang‐Li , Sidhu Karishma , Cooper Lisa , Dawson Liane , Slipper Debbie , Gavin Andrew , Lever Nigel 
Published: February 2018

AbstractBackgroundImplantable cardioverter‐defibrillator (ICD) therapy is indicated for selected heart failure patients for the primary prevention of sudden cardiac death. Little is known about the outcomes in patients selected for primary prevention device therapy in the northern region of New Zealand.MethodHeart failure patients with systolic dysfunction who underwent primary prevention ICD/cardiac resynchronization therapy‐defibrillator (CRT‐D) implantation between January 1, 2007, and June 1, 2015, were included. Complications, mortality, and hospitalization events were reviewed.ResultsThree hundred and eighty‐five primary prevention devices were implanted (269 ICD, 116 CRT‐D). Mean age at implant was 59.1 ± 11.4 years. Mean duration of follow‐up was 3.64 ± 2.17 years. The commonest cause of death was heart failure (41.8%). Only 2 patients died from sudden arrhythmic death. The 5‐year heart failure mortality rate was 6%, whereas the 5‐year sudden arrhythmic death rate was 0.3%. Heart failure hospitalizations were commoner in those who received ICD than CRT‐D (67.7% vs 25.8%, P < .001). Maori patients have low implant rates (14%) with relatively high rates of admissions with heart failure and ventricular arrhythmia admissions,ConclusionsEven in appropriately selected heart failure patients who received primary prevention devices, only a small percentage died as a result of sudden arrhythmic death. CRT‐D should be the device of choice where appropriate in heart failure patients. Significant challenges remain to improve access to device therapy and maximize benefit to those who do get implanted.
Point‐of‐care activated system versus conventional intravenous admixture system at an academic medical centre in Singapore
Authors: Woon Chin Menn , Tan Thor Eng , Hooi Pik Yee , Teoh Siang Nee , Wu Tuck Seng 
Published: February 2018

AbstractWe aim to examine the impact of a point‐of‐care (POC)‐activated system on time and cost requirements, as compared with a conventional intravenous admixture system. Time spent on intravenous piperacillin‐tazobactam administration before and after implementation of the POC‐activated system (Mini‐bag Plus®) was measured. Resource cost difference was calculated based on the difference in required manpower and material costs. The POC‐activated system reduced IV administration time by 58% (36.7 min versus 15.4 min before and after the implementation of the POC‐activated system (p < 0.05)). The total number of drugs prepared using the POC‐activated system at our institution was estimated to be 215 920 in 2015. This translates to a total nursing time saving of 76 651.6 h and resource cost saving of SGD 3 884 400. A user satisfaction survey showed that users welcomed the POC‐activated system, due to its ease of use and safety benefits. A POC‐activated system offers significant benefits over the conventional IV admixture system in terms of nursing time and cost savings, as well as improved safety.
Nuclear Magnetic Resonance Investigation of the Effect of pH on Micelle Formation by the Amino Acid‐Based Surfactant Undecyl l‐Phenylalaninate
Authors: Rothbauer Gabriel A. , Rutter Elisabeth A. , Reuter‐Seng Chelsea , Vera Simon , Billiot Eugene J. , Fang Yayin , Billiot Fereshteh H. , Morris Kevin F. 
Published: February 2018

AbstractMicelle formation by the anionic amino acid‐based surfactant undecyl l‐phenylalaninate (und‐Phe) was investigated as a function of pH in solutions containing either Na+, l‐arginine, l‐lysine, or l‐ornithine counterions. In each mixture, the surfactant's critical micelle concentration (CMC) was the lowest at low pH and increased as solutions became more basic. Below pH 9, surfactant solutions containing l‐arginine and l‐lysine had lower CMC than the corresponding solutions with Na+ counterions. Nuclear magnetic resonance (NMR) diffusometry and dynamic light scattering studies revealed that und‐Phe micelles with Na+ counterions had hydrodynamic radii of approximately 15 Å throughout the investigated pH range. Furthermore, l‐arginine, l‐lysine, and l‐ornithine were found to bind most strongly to the micelles below pH 9 when the counterions were cationic. Above pH 9, the counterions became zwitterionic and dissociated from the micelle surface. In und‐Phe/l‐arginine solution, counterion dissociation was accompanied by a decrease in the hydrodynamic radius of the micelle. However, in experiments with l‐lysine and l‐ornithine, micelle radii remained the same at low pH when counterions were bound and at high pH when they were not. This result suggested that l‐arginine is attached perpendicular to the micelle surface through its guanidinium functional group with the remainder of the molecule extending into solution. Contrastingly, l‐lysine and l‐ornithine likely bind parallel to the micelle surface with their two amine functional groups interacting with different surfactant monomers. This model was consistent with the results from two‐dimensional ROESY (rotating frame Overhauser enhancement spectroscopy) NMR experiments. Two‐dimensional NMR also showed that in und‐Phe micelles, the aromatic rings on the phenylalanine headgroups were rotated toward the hydrocarbon core of micelle.