bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic expression of 11 miRNAs in 83 consecutive primary and corresponding recurrent glioblastoma: correlation to treatment, time to recurrence, overall survival and MGMT methylation status
Authors: Matos Bostjan , Bostjancic Emanuela , Matjasic Alenka , Popovic Mara , Glavac Damjan 
Published: December 2018

Abstract

Background
Glioblastoma (GBM) is the most common and the most malignant glioma subtype. Among numerous genetic alterations, miRNAs contribute to pathogenesis of GBM and it is suggested that also to GBM recurrence and resistance to therapy. Based on publications, we have selected 11 miRNAs and analyzed their expression in GBM. We hypothesized that selected miRNAs are differentially expressed and involved in primary as well as in recurrent GBM, that show significant expressional differences when different treatment options are in question, and that are related to certain patients and tumor characteristics.

Patients and methods
Paraffin embedded tissues, obtained from primary and corresponding recurrent tumor from 83 patients with primary GBM were used. Eleven miRNAs (miR-7, miR-9, miR-15b, miR-21, miR-26b, miR-124a, miR-199a, let-7a, let-7b, let-7d, and let-7f) were selected for qPCR expression analysis. For patients who received temozolamide (TMZ) as chemotherapeutic drug, O6-methylguanine-DNA methyltransferase (MGMT) methylation status was defined using the methyl-specific PCR.

Results
There was a significant change in expression of miR-7, miR-9, miR-21, miR-26b, mirR-124a, miR-199a and let-7f in recurrent tumor compared to the primary. In recurrent tumor, miR-15b, let-7d and let-7f significantly changed comparing both treatment options. We also observed difference in progression free survival between patients that received radiotherapy and patients that received radiotherapy and chemotherapy, and longer survival for patients who received chemotherapy after second surgery compared to not treated patients. miR-26b showed correlation to progression free survival and let-7f to overall survival. We did not find any expression difference between the tumors with and without methylated MGMT.

Conclusions
Our data suggest that analyzed miRNAs may not only contribute to pathogenesis of primary GBM, but also to tumor progression and its recurrence. Moreover, expression of certain miRNAs appears to be therapy-dependent and as such they might serve as additional biomarker for recurrence prediction and potentially predict a therapy-resistance.
Optic nerve ultrasound for fluid status assessment in patients with severe preeclampsia
Authors: Simenc Gabrijela Brzan , Ambrozic Jana , Prokselj Katja , Tul Natasa , Cvijic Marta , Mirkovic Tomislav , Lackner Helmut Karl , Lucovnik Miha 
Published: December 2018

Abstract

Background
There are no data on usefulness of optic nerve sheath diameter (ONSD) as a marker of patient’s fluid status in preeclampsia. The objective was to examine potential correlation between ONSD and lung ultrasound estimates of extravascular lung water in severe preeclampsia.

Patients and methods
Thirty patients with severe preeclampsia were included. Optic and lung ultrasound were performed within 24 hours from delivery. ONSD was measured 3 mm behind the globe. Lung ultrasound Echo Comet Score (ECS) was obtained summing B-lines (“comet tails”) in parasternal intercostal spaces bilaterally. Pearson’s correlation analysis was used to assess the relationship between ONSD and ECS (p < 0.05 significant).

Results
Median ONSD was 5.7 mm (range 3.8–7.5 mm). Median ECS value was 19 (range 0-24). Statistically significant correlation was found between ONSD and ECS (r2 = 0.464; p < 0.001).

Conclusions
Significant correlation between ONSD and ECS suggests optic ultrasound could be used for assessing fluid status and guiding peripartum fluid therapy in patients with severe preeclampsia.
Wellness Tourism: What Motivates the Consumer
Authors: Árpási Zoltán 
Published: December 2018

Abstract
In this paper one research will be presented, which is focusing on the factors of decision making in the tourism sector. Health and wellness tourism have become a major trend in the past years, since more and more consumer care about their health.
The stressful life, people live nowadays also lead to increased health risk which justifies the growing need for relaxation during the holidays as well. In the study we also present the factors of an analysis and the key motivators when deciding about the destination.
ICD-10 Tanı Kodlama Sistemine Aile Hekimlerinin Bakışı
Authors: Öz Semra , Karagöz Rıdvan , Altındiş Selma , Aslan Ferhat Gürkan , Atasoy Ali Rıza , ŞİMSİR İsmail , İnci Mustafa Baran 
Published: December 2018

Amaç: Uluslararası Hastalık Sınıflaması olarak Türkçe’ye çevrilen ICD epidemiyolojik çalışmalar ve sağlık hizmetlerinin yönetimi için önemlidir. Çalışmamızda ICD-10 Tanı Kodlama Sisteminin aile hekimlerinin bakışı ile değerlendirilmesi amaçlandı. Yöntem: Çalışma Şubat-Mayıs 2016 tarihleri arasında Sakarya ilinde çalışan aile hekimleri üzerinde gerçekleştirilen tanımlayıcı tipte bir araştırmadır. Araştırma evrenini Sakarya ilindeki tüm aile hekimleri (292) oluşturmuştur.Bulgular: Çalışma grubunun 55’i (%18,8) tanılarını ICD-10 sistemine tam ve düzgün olarak kaydettiğini belirtmiştir. Katılımcılardan 56’sı (%19,2) ICD-10 sistemi ile ilgili eğitim aldığını ifade ederken 190’ı (%65,1) eğitim almanın gerekli olduğunu bildirmiştir. ICD-10 kodlama sisteminin çalıştığı bölüme ait her tanı kodunu içerdiğini belirten 39 (%13,4) kişi idi. Katılımcılardan 243’ü (%83,2) ICD-10 tanı kodunu bulamadığında benzer veya yakın bir kodu girdiğini bildirmiştir.Sonuç: Sonuç olarak çalışmadaki aile hekimlerinin az bir kısmı ICD-10 konusunda eğitim alırken çoğunun ise herhangi bir eğitim almadıkları, dolayısıyla da sistemi kullanmada çeşitli zorluklar yaşadıklarını belirtmişlerdir. ICD-10 sisteminin verimli ve etkili kullanılabilmesi için eğitim alan hekimlerin sayısının arttırılması önerilmektedir.
Percepción de la variabilidad pluviométrica en las poblaciones costeras del sur de la Provincia de Buenos Aires (Argentina): una propuesta para el diseño de estrategias de adaptación
Authors: Bustos Luján , Ferrelli Federico 
Published: December 2018

<p>La región del sudoeste de la provincia de Buenos Aires se caracteriza por presentar una alternancia de eventos secos y húmedos que los actores sociales (AS) perciben en diferentes situaciones cotidianas. El objetivo de este trabajo fue evaluar la percepción de esos AS sobre la variabilidad pluviométrica con el fin de diseñar un plan de manejo sustentable del territorio. Se aplicaron entrevistas y talleres participativos y se analizaron datos diarios, mensuales y anuales de precipitación. Durante un evento seco, los AS observaron, entre otras situaciones, una reducción en el crecimiento de los peces, perjudicando las capturas. Como consecuencia, sugirieron medidas de adaptación tales como vedas más prolongadas. Por otro lado, en un evento lluvioso, identificaron daños en los médanos y playas por las lluvias intensas, perjudicando el desarrollo de actividades turístico-recreativas. Los resultados obtenidos constituyen una fuente de información sólida ya que involucran el conocimiento de la variabilidad pluviométrica junto con la participación activa de AS.<br /><br /><br /></p><p> </p><p> </p><p> </p>
Study on Correlation between Serum Prostate Specific Antigen and Various Prostatic Pathology
Authors: Mainali Nirajan , Nepal Niraj , Chaudhary Prabesh Kumar , Shrestha Jit 
Published: December 2018

Introduction: Prostatic enlargement that may due to any cause may give rise to bladder outlet obstruction. Prostatic specific antigen is the enzyme that is responsible for liquefaction of semen within a few minutes after it has clotted. Prostatic specific antigen is a widely used tumor marker for prostatic cancer. Prostatic specific antigen levels in the blood go up if the barrier between the lining epithelium and the blood stream is damaged. This study was done to determine the correlation between serum Prostatic specific antigen level and histological diagnosis in prostatic biopsy.Material and Methods: This is a one year prospective study carried out in the Department of Pathology, Nobel Medical College from August 16, 2016 to August 15 2017. A total of 175 cases were included in the study. Patient Prostatic specific antigen level were noted and biopsy specimen was collected after operation. Histopathological examination was done and correlation between HPE diagnosis and serum Prostatic specific antigen level was done.Results: Benign Prostatic Hyperplasia was the most common diagnosis that was encountered. Majority of the cases had a serum Prostatic specific antigen level less than 10 ng/ml. Serum Prostatic specific antigen level of more than 30 ng/ml was seen only in prostatic carcinoma.Conclusions: Serum Prostatic specific antigen is organ specific but not a disease for prostate. It can be used to monitor the carcinoma of the prostate rather than the diagnosis of the carcinoma.
Penerapan Model Pembelajaran Realistic Mathematics Education (RME) untuk Meningkatkan Motivasi dan Prestasi Belajar Matematika Materi Statistika pada Peserta Didik Kelas XI TP3RP SMK Negeri 1 Kendal Tahun Pelajaran 2015/2016
Authors: Nugroho Hendy 
Published: December 2018

Penelitian ini bertujuan untuk memberikan gambaran tentang peningkatan motivasi dan prestasi belajar matematika pada materi Statistika dengan menerapkan model pembelajaran Realistic Mathematics Education (RME). Penelitian yang dilaksanakan merupakan penelitian tindakan kelas. Subjek penelitian adalah peserta didik kelas XI kompetensi keahlian Teknik Produksi dan Penyiaran Program Radio dan Pertelevisian (XI TP3RP) SMK Negeri 1 Kendal Tahun Pelajaran 2015/2016 sebanyak 31 peserta didik. Kegiatan penelitian dilaksanakan dalam dua siklus, yang masing-masing terdiri dari perencanaan, pelaksanaan dan observasi, serta refleksi. Pengumpulan data dilakukan melalui tes tertulis untuk mengukur prestasi belajar peserta didik. Sedangkan observasi, angket, dan wawancara dilakukan untuk mengetahui motivasi peserta didik. Untuk menginterpretasikan data digunakan metode statistika sederhana. Hasil penelitian menunjukkan bahwa berdasakan hasil observasi, rata-rata motivasi meningkat dari 71% pada siklus pertama menjadi 83% pada siklus kedua. Sedangkan berdasarkan hasil angket, motivasi kategori tinggi dan sangat tinggi meningkat sebanyak 73% pada siklus pertama menjadi 80% pada siklus kedua. Berdasarkan hasil tes, banyaknya peserta didik yang tuntas (mencapai KKM) pada siklus pertama dan siklus kedua mencapai 33%.
Kata kunci: Realistic Mathematics Education (RME), motivasi, prestasi.
Abstract
This research aims to describe the increasing of motivation and achievement of mathematics learning in Statistics materials by applying Realistic Mathematics Education (RME) learning model. The research is a classroom action research. The subjects of the research were 31 IX grade students of Techniques of Radio and Television Broadcasting and Program (XI TP3RP) SMK Negeri 1 Kendal 2015/2016. Research activities are conducted in two cycles. Each cycle consists of planning, implementation and observation, and reflection. Data were collected through written test to measure learners' learning achievement. While the observations, questionnaires, and interviews were done to determine the motivation of learners. Simple statistical methods are used to interpret the data. The results showed that based on observations, the average motivation increased from 71% in the first cycle to 83% in the second cycle. While based on the questionnaire, high and very high category motivation increased by 73% in the first cycle to 80% in the second cycle. The number of students who complete (reach KKM) in the first cycle and the second cycle reached 33%.
Keywords: Realistic Mathematics Education (RME), motivation, achievement.
EKARISTI DI MEJA PERJAMUAN ESKATOLOGI | THE EUCHARIST AT THE ESCHATOLOGICAL TABLE
Authors: Ledot Ignasius 
Published: December 2018

<b>Abstract</b>

This text critiques the concept of eucharist-eschatology which is
found in two works by local NTT artists. Using an eschatological
approach and a study of the document Sacrosanctum Concilium
regarding liturgy, two important messages have been identified in
those works. First, solidarity is an effort to share. This virtue is
primarily seen in the attitude of God who left His/Her grandeur
and took on the form of a human being. Second, the act of giving
as a form of solidarity comes from an awareness of the missionary
aspect of the vocation of the faithful. Via the artistic works of
two local artists, the faithful are helped to consider and idealise
the eschatological eucharist. These two works show the clear
connection between the celebration of the eucharist in the world
and the eternal eucharist, the place where humanity meets God
who is both intimate but also majestic.

<b>Keywords:</b> Church, Eucharist, Eschatology, Last Supper,
Catechetics, Lord

<b>Abstrak</b>

Tulisan ini bertujuan untuk mengulas konsep ekaristi-eskatologi
yang terdapat di dalam dua lukisan karya pelukis lokal NTT.
Dengan menggunakan pendekatan eskatologi dan studi dokumen
Sacrosanctum Concilium tentang liturgi ditemukan dua pesan
penting dari dua lukisan tersebut. Pertama, solidaritas sebagai
usaha untuk saling berbagi. Kebajikan ini pertama-tama tampak
dalam sikap Allah yang memutuskan untuk meninggalkan
keagungan-Nya dan mengambil rupa manusia. Kedua, aktus
memberi sebagai bentuk solidaritas terlahir dari kesadaran akan
aspek misioner dari panggilan umat beriman. Melalui karya
lukis dua seniman lokal ini, umat dibantu untuk membayangkan
dan mencita-citakan ekaristi eskatologi. Dua lukisan ini
memperlihatkan hubungan yang jelas antara perayaan ekaristi di
dunia dan ekaristi kekal, tempat manusia menjumpai Allah yang
akrab sekaligus yang agung.

<b>Kata-kata Kunci:</b> Gereja, Ekaristi, Eskatologi, Perjamuan Akhir,
Katekese, Tuhan
COLOR RECOGNITION WEARABLE DEVICE USING MACHINE LEARNING FOR VISUALY IMPAIRED PERSON
Authors: NIK HASHIM NIK NUR WAHIDAH , MOHAMED BOLAD TAREK , Mohamad Hanif Noor Hazrin Hany 
Published: December 2018

ABSTRACT: Recognizing colors is a concerning problem for the visually impaired person. The aim of this paper is to convert colors to sound and vibration in order to allow fully/partially blind people to have a â€˜feelingâ€™ or better understanding of the different colors around them. The idea is to develop a device that can produce vibration for colors. The user can also hear the name of the color along with â€˜feelingâ€™ the vibration. Two algorithms were used to distinguish between colors; RGB to HSV color conversion in comparison with neural network and decision tree based machine learning algorithms. Raspberry Pi 3 with Open Source Computer Vision (OpenCV) software handles the image processing. The results for RGB to HSV color conversion algorithm were performed with 3 different colors (red, blue, and green). In addition, neural network and decision tree algorithms were trained and tested with eight colors (red, green, blue, orange, yellow, purple, white, and black) for the conversion to sound and vibration. Neural network and decision tree algorithms achieved higher accuracy and efficiency for the majority of tested colors as compared to the RGB to HSV.
ABSTRAK: Membezakan antara warna adalah masalah yang merunsingkan terutamanya kepada mereka yang buta, separa buta atau buta warna. Tujuan kertas penyelidikan ini adalah untuk membentangkan kaedah menukar warna kepada bunyi dan getaran bagi membolehkan individu yang buta, separa buta atau buta warna untuk mendapat â€˜perasaanâ€™ atau pemahaman yang lebih baik tentang warna-warna yang berbeza disekeliling mereka. Idea yang dicadangkan adalah dengan membuat sebuah alat yang dapat menghasilkan getaran bagi setiap warna yang berbeza. Disamping itu, pengguna juga dapat mendengar nama warna tersebut. Algoritma yang digunakan untuk membezakan antara warna adalah penukaran warna RGB kepada HSV yang dibandingkan dengan rangkaian neural dan algoritma pembelajaran mesin berasaskan pokok keputusan. Raspberry Pi 3 bersaiz kad kredit dengan perisian Open Source Computer Vision (OpenCV) mengendalikan pemprosesan imej. Hasil algoritma penukaran warna RGB kepada HSV telah dilakukan dengan tiga warna yang berbeza (merah, biru, dan hijau). Tambahan pula, hasil rangkaian neural dan algoritma berasaskan pokok keputusan telah dilakukan dengan lapan warna (merah, hijau, biru, oren, kuning, ungu, putih, dan hitam) dengan penukaran warna tersebut kepada bunyi dan getaran. Selain itu, hasil rangkaian neural dan algoritma berasaskan pokok keputusan mencapai hasil dapatan yang baik dengan ketepatan dan kecekapan yang tinggi bagi kebanyakan warna yang diuji berbanding RGB kepada HSV.
Spatio-temporal distribution of atmospheric precipitation in the Odesa region at the beginning of the 21st century
Authors: Ivus H. P. , Goncharova L. D. , Kosolapova N. I. 
Published: December 2018

During the last decade of the 20th and at the beginning of the 21st century there was a need for a higher level of understanding of the climate system and development of opportunities to prevent climate change and, first of all, understanding of dangerous natural hydrometeorological phenomena. The research of the latter is based on contemporary ideas of the theory of climate whose main concepts found their further development in the study of changes and fluctuations of the today's climate. For its climatic characteristics the South of Ukraine is considered as a separate region. This is due to not only the influence of the Black Sea but also to the specific features of the atmospheric circulation. Precipitation is one of the most important characteristics of humidification and appears to be the most variable meteorological value both in space and time. According to the results of modern studies the amount of precipitation within the territory of Ukraine and its individual regions was changing at the end of the 20th century and this change is still observed at the beginning of the 21st century. Therefore, the purpose of this scientific study is to determine the peculiarities of the spatio-temporal distribution of atmospheric precipitation in the territory of the Odesa Region over the recent decades. To complete this task we used statistical methods of processing the output information which included time data for 00, 06, 12 and 18 hours.
Based on peculiarities of the structure of the long-term course of atmospheric precipitation in the territory of the Odesa region the following five regions were defined: southern, northwest, northern, eastern and coastal. Using the integral Fourier transform we managed to determine probable periodic oscillations (quasi-two-month, quasi-three-month, half-year and quasi-ten-month ones).
This article presents the main results of one of the sections of the research work "Forecasting of dangerous meteorological phenomena over the southern regions of Ukraine" which is performed at the Department of Meteorology and Climatology of the Odessa State Environmental University.
Género, institucionalismo y marginalidad: la gestión del agua de uso doméstico como desafío para el empoderamiento de las mujeres. El caso de la ciudad de La Paz, Baja California Sur, México
Authors: Castorena Davis Lorella , Martínez Valencia Arely Madai 
Published: December 2018

El objetivo de este artículo es analizar la persistencia de la división tradicional del trabajo doméstico. La escasa valoración de las actividades de reproducción de la vida, como la maternidad, y el cuidado y atención a otras personas, sumada a condiciones de marginalidad, derivan en un incremento de las cargas de trabajo y reducen las probabilidades de empoderamiento de las mujeres. Asimismo la mala distribución de recursos como el agua, junto con su escasez y deficiente calidad, se tornan en obstáculos para alcanzar la igualdad de género. El vínculo teórico entre género, institucionalismo y marginalidad, así como la selección del caso de estudio, representan los aportes más relevantes de este trabajo, en tanto permiten mostrar el impacto que el funcionamiento de la institución encargada de la distribución del agua tiene sobre las mujeres, en la medida que refuerza el hábito y la norma cultural que las responsabiliza de resolver el abasto de agua al interior de sus hogares. Se analiza la problemática de género que enfrentan mujeres jefas de familia respecto al agua de uso doméstico en cinco colonias marginadas de la ciudad de La Paz, en las que se aplicó un total de 42 cuestionarios gracias a los cuales se concluyó que las mujeres jefas de hogares marginados además de la sobrecarga de trabajo doméstico y de cuidados derivados del abasto insuficiente y deficiente de agua que provee el organismo operador, deben enfrentar los costos derivados tanto del conjunto de diligencias cotidianas que realizan para garantizar que el agua que reciben alcance para satisfacer sus necesidades mínimas, como del gasto que representa el consumo de agua embotellada proveniente de las plantas purificadoras locales o de barrio.
KONSEP PENGEMBANGAN KOTA BANDA ACEH SEBAGAI KOTA WISATA TSUNAMI
Authors: Wulandari Elysa , Safriana Desi 
Published: December 2018

ABSTRACT: The city of Banda Aceh has experienced several tsunamis that destroy civilization on it. Currently every year tsunami warnings are conducted both national and international scale, both academic and tourism purposes. The warning brings many people who need information about the existence of the city of Banda Aceh from previous times. Therefore it is necessary to extract and study the important objects that describe the past civilization of the city of Banda Aceh, to be realized as part of the space elements of today's city of Banda Aceh. The study was conducted on several important objects from the XVII century on the coast that gave the image of the city of Banda Aceh as a cosmopolitan city and a maritime city. Approach the study by revealing the architectural aspect of the object and the proposed zoning pattern in each object. The results of the discussion appear to present historical stories through replicas of objects and graves that have a place to contemplate as a support facility. The conclusion of the paper provides a theoretical framework on tsunami impact tourism development in the city of Banda Aceh. This paper is considered important as one way of strengthening the self of the Indonesian nation about the disclosure of glory and identity of the past, useful for building the character of the nation. Besides, it is also to open the insight for the government and city development actors in preparing the city of Banda Aceh as a tourist city of the tsunami. Keywords: Banda Aceh City, Tsunami Tourism, Architectural Design ABSTRAK: Kota Banda Aceh telah mengalami beberapa kali tsunami yang merusak peradaban di atasnya. Saat ini setiap tahun dilaksanakan peringatan tsunami baik skala nasional maupun international, baik tujuan akademik maupun pariwisata. Peringatan tersebut menghadirkan banyak orang yang membutuhkan informasi tentang keberadaan kota Banda Aceh dari masa-masa sebelumnya. Oleh karena itu diperlukan penggalian dan kajian objek penting yang menggambarkan peradaban masa lalu kota Banda Aceh, untuk diwujudkan sebagai bagian elemen ruang kota Banda Aceh masa kini. Kajian dilakukan pada beberapa objek penting mulai dari abad XVII di bagian pesisir yang memberi citra kota Banda Aceh sebagai kota kosmopolitan dan Kota maritim. Pendekatan kajian dengan mengungkapkan aspek arsitektural objek dan usulan pola penataan zona di setiap objek. Hasil pembahasan tampak bahwa menghadirkan cerita sejarah melalui replika objek dan kuburan yang dilengkapi tempat untuk berkontempelasi sebagai fasilitas pendukung. Kesimpulan tulisan memberikan kerangka teoritik tentang pengembangan objek wisata dampak tsunami di kota Banda Aceh. Tulisan ini dirasa penting sebagai salah satu cara penguat jadi diri bangsa Indonesia tentang pengungkapan kejayaan dan identitas masa lalu, berguna bagi membangun karakter bangsa. Disamping itu juga untuk membuka wawasan bagi pemerintah dan pelaku pembangunan kota dalam menyiapkan kota Banda Aceh sebagai kota wisata tsunami.