bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disruption of NMDAR Function Prevents Normal Experience-Dependent Homeostatic Synaptic Plasticity in Mouse Primary Visual Cortex
Authors: Rodriguez Gabriela , Mesik Lukas , Gao Ming , Parkins Samuel , Saha Rinki , Lee Hey-Kyoung 
Published: August 2019

Homeostatic regulation of synaptic strength allows for maintenance of neural activity within a dynamic range for proper circuit function. There are largely two distinct modes of synaptic plasticity that allow for homeostatic adaptation of cortical circuits: synaptic scaling and sliding threshold (BCM theory). Previous findings suggest that the induction of synaptic scaling is not prevented by blocking NMDARs, whereas the sliding threshold model posits that the synaptic modification threshold of LTP and LTD readjusts with activity and thus the outcome of synaptic plasticity is NMDAR dependent. Although synaptic scaling and sliding threshold have been considered two distinct mechanisms, there are indications from recent studies that these two modes of homeostatic plasticity may interact or that they may operate under two distinct activity regimes. Here, we report using both sexes of mouse that acute genetic knock-out of the obligatory subunit of NMDAR or acute pharmacological block of NMDAR prevents experience-dependent homeostatic regulation of AMPAR-mediated miniature EPSCs in layer 2/3 of visual cortex. This was not due to gross changes in postsynaptic neuronal activity with inhibiting NMDAR function as determine by c-Fos expression and two-photon Ca2+imaging in awake mice. Our results suggest that experience-dependent homeostatic regulation of intact cortical circuits is mediated by NMDAR-dependent plasticity mechanisms, which supports a sliding threshold model of homeostatic adaptation.SIGNIFICANCE STATEMENTProlonged changes in sensory experience lead to homeostatic adaptation of excitatory synaptic strength in sensory cortices. Both sliding threshold and synaptic scaling models can account for the observed homeostatic synaptic plasticity. Here we report that visual experience-dependent homeostatic plasticity of excitatory synapses observed in superficial layers of visual cortex is dependent on NMDAR function. In particular, both strengthening of synapses induced by visual deprivation and the subsequent weakening by reinstatement of visual experience were prevented in the absence of functional NMDARs. Our results suggest that sensory experience-dependent homeostatic adaptation depends on NMDARs, which supports the sliding threshold model of plasticity and input-specific homeostatic control observedin vivo.
Buscando pertenecer: estudiantes latinos de primera y segunda generación en la Universidad de Purdue, Indiana
Authors: Veiman Echeverría Marilyn , Nowakowski Justin , Rojas Carballo Fabio 
Published: August 2019

Los estudiantes latinos, hijos de inmigrantes (segunda generación) e inmigrantes, que se han criado en comunidades locales en exclusión, como los enclaves, descubren que integrarse a la comunidad universitaria es una transición que va más allá del reto académico. Su bagaje cultural y posición socioeconómica los diferencia en un contexto sociocultural predominantemente caucásico y de clase media. Los estudios señalan que lograr un sentido de pertenencia a la comunidad universitaria es clave tanto para la consecución como para la persistencia académica y la falta de esta experiencia se asocia a un alto porcentaje de deserción de los estudios por parte de latinos.
Reconociendo que el carecer de un sentimiento de comunidad en el campus es una causa de la deserción, en este proyecto se investigan algunos de los elementos que producen la experiencia de un sentido de pertenencia en el estudiante latino de la Universidad de Purdue en Indiana, EE.UU. Se solicitó la participación voluntaria de parte del grupo de interés y se aplicaron dos instrumentos: una entrevista a profundidad (indagando en una selección de indicadores como las comunidades de origen, el idioma del hogar y la percepción de inclusión o exclusión en el ambiente universitario) y una encuesta de valor numérico para analizar el “sentido de pertenencia”, cuyos resultados se combinaron con el promedio ponderado, en busca de relaciones con la persistencia académica.
Disturbance of food behavior as a predictor of obesity and metabolic syndrome: is possible prevention?
Authors: Bulatova Elena M. , But’ko Pavel V. , Shabalov Alexandr M. 
Published: August 2019

Relevance of the study. Eating disorders in children in early childhood are among the leading causes of obesity and the metabolic syndrome. The aim of the study. For the prevention of noncommunicable diseases (obesity, metabolic syndrome) in the future, to carry out the analysis of actual nutrition of children of early age and to identify unfavorable factors influencing the formation of eating behavior.
Materials and methods. A survey of 297 parents with children aged 1 to 3 years. The survey is based on the Google Form on-line platform. The platform for the survey was the social network VKontakte, in particular, thematic groups for mothers with children from 1 to 3 years old. The questions were developed taking into account the recommendations set out in the modern normative documents on children’s nutrition.
Results. According to the data, only 28% of children had 5 organized meals per day, 51% had 4 feedings per day, 21% had 3 feedings. More than half of the children (52%) had 2 snacks per day. The most common snacks were flour products (30%), as well as vegetables and fruits (27%). Most parents (78%) did not pay attention to the design of dishes, 16% did not provide adequate replacement of dishes that the child refused. It should be noted that 12% of children do not like vegetables. A joint meal was not organized in 7% of families. During the meal, 40% of parents and 23% of children used a TV/tablet/smartphone. There are a large number of families (37%) who visit fast food restaurants (fast food) with young children, while 26% of them offered menu items to children.
Conclusion. Identified adverse factors in the formation of eating behavior require changes in the approaches to monitoring a young child on nutritional issues both by a pediatrician and by the implementation of a number of recommendations by parents.
Espiritualidade no ambiente de trabalho: evidências em três casos
Authors: Pinheiro Luciano , Froehlich Cristiane , Konrath Karoline 
Published: August 2019

O objetivo deste trabalho é analisar a compreensão e presença do conceito de espiritualidade no contexto organizacional. Para isso buscou-se: (a) verificar o entendimento de gestores e colaboradores das organizações estudadas sobre este conceito; (b) investigar a presença ou não de práticas associadas às dimensões da espiritualidade; (c) compreender o papel do líder neste contexto. Efetuou-se uma pesquisa exploratória e descritiva, qualitativa e pesquisa de campo. A coleta de dados ocorreu através de entrevistas semiestruturadas em três empresas da região metropolitana de Porto Alegre (RS): uma da área da educação, nomeada de Empresa S; uma loja de departamentos, denominada de Empresa C; e uma fábrica de calçados femininos, chamada de Empresa I. Os principais resultados demonstram que gestores e colaboradores destas empresas possuem entendimento de espiritualidade baseados no senso comum, e poucos possuem conhecimento a respeito da espiritualidade aplicada à gestão; é possível identificar nas empresas práticas que podem ser consideradas e classificadas dentro das cinco dimensões da espiritualidade.
Development of Kernel Mode RAM Driver for RAM Image on Windows
Authors: Süzen Ahmet Ali , Taşdelen Kubilay , Küçüksille Ecir Uğur 
Published: August 2019

In the
field of computer forensics live analysis through immediate intervention is an
important way of gathering electronic evidence. The way to obtain evidence from
volatile data using live analysis is to take an image of the RAM (Random Access
Memory). The entire RAM has to be copied in order to import data from this
image. However, since the user mode is the default mode in Windows operating
systems only the running processes can be accessed. Therefore, RAM imaging software needs to work
at Kernel Mode level. In this study, a RAM driver was developed using WDK
(Window Driver Kit) to enable RAM imaging software to run in Kernel Mode. The
developed driver works on Windows 8, 8.1 and 10 (32 bit and 64 bit) operating
systems. Virtual addresses, physical addresses and table pages for RAM can be
accessed using the developed RAM driver. In this way, image acquisition
software using this driver is able to carry out bit-to-bit copying of RAM. In
addition, a program to import a RAM image in c ++ using this driver has also
been developed. When the image retrieval software is installed in RAM it
occupies a meager 156 KB of space. Compared to the existing image acquisition
software, the developed RAM driver and software seem to use the least RAM. In
addition, there are no examples of Kernel Mode RAM Drivers developed using WDK
in the literature.
Technology and Physico-Mechanical Properties of Claydite Foam Concrete for Monolithic and Prefabricated Construction
Authors: Mordzich M. M. 
Published: August 2019

Theoretical and experimental investigations have resulted in obtaining an effective insulating and structural material (claydite foam concrete) that is not subjected to slump and shrinkage in the range of main grades used in construction in terms of average density D300–D700, characterized by 5–31 % greater strength and 8–27 % elasticity modulus, as well as a higher (£30.7 %) level of vapor permeability and moisture return (by 17.4–46.7 %) with lower values (by 10.0–83.2 %) of water absorption, sorption moisture and thermal conductivity in comparison with aerated concrete of autoclave hardening and foam concrete of equal density. A three-stage technology has been developed for preparing claydite foam concrete. At the first stage cement dough is prepared and if it is necessary an optimum amount of hardening accelerator (1 % CaCl2 from cement mass) and additives condensing cement stone structure (1 % Al2SO4 from cement mass ) are introduced into it, they prevent slump of a binder (foam concrete) during the subsequent hardening, and in combination with 0.5 % from cement mass “Hydroxypropylmethylcellulose УСК-200 TT” – and shrinkage of foam and claydite foam concrete during the subsequent drying. At the second stage, the binder is aerated while introducing protein-based foam agent (Laston) into the cement dough in an optimal amount (depending on the given density) 0.5–1.3 % from the cement mass; and at the third stage, expanded clay gravel is introduced into prepared foam concrete mixture (in rational amount of approximately 0.7–0.8 m3 per 1 m3 of claydite foam concrete) with continuous mixing for 60–90 seconds. Methodologies for calculation of foamand claydite foam concrete compositions have been developed; molding modes of expanded clay foam concrete with high degree of homogeneity (variation coefficient of density and strength uk £ 6.2 % in the process of manufacturing molding with layer height up to 1500 mm) have been justified that confirms efficiency of the proposed technology.
Control of Mechatronic System Based on Multilink Robot-Manipulators
Authors: Hurski N. N. , Skudnyakov Yu. A. , Artsiushchyk V. S. , Bezruchko A. N. 
Published: August 2019

The task of controlling multi-link robots with manipulators for implementation of high-tech processes in industry has been considered in the paper. The paper presents sequential steps of using computer technology in construction of robotic-manipulators, including mathematical, algorithmic, and hardware and software tools for creating a multi-drive mechatronic system controlled by OMRON industrial microcontroller. A kinematic scheme of a robot manipulator has been described in the paper and it performs the following two types of movements – rotation around the z axis and rectilinear movement of a working element along a turning radius with precise positioning at a given point in the working space. Electromechanical design of the manipulator allows to ensure transportation of production objects in accordance with a given technological process. For designing the technological process of transporting production objects, a software module has been developed that makes it possible to automate description of basic operations for movement of the robot manipulator working body with subsequent automatic generation of a command sequence for a control program ensuring operation of electric drives in manipulator links in real time. To speed up the process of designing trajectory of the working body, a spatial simulation model of a robot-manipulator in the MatLab-Simulink environment has been developed. The paper considers a generalized diagram of a mechatronic control system for a robot-manipulator based on the OMRON programmable logic controller operating under control of a program developed in the programming environment Sysmac Studio Automation. A program for a programmable terminal with interface elements and animation elements has been developed for industrial use of the mechatronic system during adjustment and operation period. The paper provides an appearance of a robot-manipulator prototype. The developed mechatronic system of the robot-manipulator can be technologically oriented towards solving other problems of industrial production.
Association between Toxoplasma gondii infection and thyroid dysfunction: a case-control seroprevalence study
Authors: Alvarado-Esqu Cosme , Ramos-Nevarez Agar , Guido-Arreola Carlos Alberto , Cerrillo-Soto Sandra Margarita , Pérez-Álamos Alma Rosa , Estrada-Martínez Sergio , Gutierrez-Martinez Verónica Dayali , Sifuentes-Alvarez Antonio , Ramírez-Valles Eda Guadalupe , Contreras-Cisneros Edith 
Published: August 2019

Abstract
Background: The association between Toxoplasma gondii infection and thyroid disease has been poorly studied. Therefore, we sought to determine the association between T. gondii seropositivity and thyroid dysfunction.
Methods: We performed an age- and gender-matched case-control study of 176 patients suffering from hypothyroidism (n=161) or hyperthyroidism (n=15) and 528 control subjects without these diseases in a public hospital in Durango City, Mexico. Anti-Toxoplasma IgG antibodies were determined in sera from cases and controls using a commercially available enzyme-linked immunoassay.
Results: Anti-T. gondii IgG antibodies were found in 11 (6.3%) of 176 patients suffering from thyroid dysfunction and in 48 (9.1%) of 528 control subjects (OR=0.66; 95% CI: 0.33-1.31; P=0.23). Stratification by two groups of age (50 years and younger, and 51 year and older) showed that the youngest group of patients with thyroid dysfunction had a significantly lower seroprevalence of T. gondii infection than its age- and gender-matched control group (1/83: 1.2% vs 23/257: 8.6%; OR=0.12; 95% CI: 0.01-0.93; P=0.01). This stratification also showed that the youngest group of patients with hypothyroidism had a significantly lower seroprevalence of T. gondii infection than its age- and gender matched control group (0/75: 0% vs 21/233: 9.0%; P=0.003).
Conclusions: Our results suggest that thyroid dysfunction is not associated with seropositivity to T. gondii in general; however, in young (50 years or less) patients, a negative association between infection and thyroid dysfunction and hypothyroidism was found. Further research to confirm this negative association is needed.
Burden of HPV Related Anogenital Diseases in Young Women in Germany – An Analysis of German Statutory Health Insurance Claims Data From 2012–2017
Authors: Reuschenbach Miriam , Mihm Sarah , Wölle Regine , Schneider Kim Maren , Jacob Christian , Braun Sebastian , Greiner Wolfgang , Hampl Monika 
Published: August 2019

Abstract
BackgroundMost women and men will be infected with human papillomavirus (HPV) at least once in their lifetime. Infections with low-risk types can cause genital warts, whereas high-risk types can cause malignant tumors. The aim of this study was to determine the burden of anogenital diseases potentially related to HPV in young women based on German statutory health insurance claims data.MethodsWe conducted a retrospective claims data analysis using the “Institute for Applied Health Research Berlin” (InGef) research database, containing claims data of approximately 4 million insured individuals. In the period from 2012-2017 all women born 1989-1992 were identified if they were continuously insured at an age between 23-25 years. Using ICD-10-GM codes (verified diagnosis in the outpatient sector or primary or secondary diagnosis in the inpatient sector) the administrative prevalence (95% confidence interval) of genital warts (A63.0), anogenital diseases grade I (K62.8, N87.0, N89.0, N90.0), grade II (N87.1, N89.1, N90.1) and grade III (D01.3, D06.-, D06.0, D07.1, D07.2, N87.2, N89.2, N90.2) was calculated.ResultsFrom 2012-2017, a total of 15,358 (birth cohort 1989), 16,027 (birth cohort 1990), 14,748 (birth cohort 1991) and 14,862 (birth cohort 1992) women at the age of 23-25 were identified. A decrease of the administrative prevalence was observed in genital warts (1.30% (1.12-1.49) birth cohort 1989 vs. 0.94% (0.79-1.10) birth cohort 1992) and anogenital diseases grade III (1.09% (0.93-1.26) birth cohort 1989 vs. 0.71% (0.58-0.86) birth cohort 1992). In anogenital diseases grade III, this trend was especially observed for severe cervical dysplasia (N87.2) (0.91% (0.76-1.07) birth cohort 1989 vs. 0.60% (0.48-0.74) birth cohort 1992). In contrast, anogenital diseases grade I (1.41% (1.23-1.61) birth cohort 1989 vs. 1.31% (1.14-1.51) birth cohort 1992) and grade II (0.61% (0.49-0.75) birth cohort 1989 vs. 0.52% (0.42-0.65) birth cohort 1992) remained stable.ConclusionsA decrease of the burden of anogenital disease potentially related to HPV was observed in the younger birth cohorts. This trend was observed especially for genital warts and anogenital diseases grade III. Further research to investigate this trend for the upcoming years and for following birth cohorts is necessary also considering varying HPV vaccination coverage.
53 Years Old is A Reasonable Cut-Off Value To Define Young And Old Patients In Clear Cell Renal Cell Carcinoma:A Study Based On TCGA And SEER Database
Authors: Tang Fucai , Lu Zechao , He Chengwu , Zhang Hanbin , Wu Weijia , He Zhaohui 
Published: August 2019

Abstract
Background

The objectives of this study were to screen out cut-off age value and age-related differentially expressed genes (DEGs) in clear cell renal cell carcinoma (CCRCC) from Surveillance Epidemiology and End Results (SEER) database and The Cancer Genome Atlas (TCGA) database.

Methods

We selected 45,974 CCRCC patients from SEER and 530 RNA-seq data from TCGA database. The age cut-off value was defined using the X-tile program. Propensity score matching (PSM) was used to balance the differences between young and old groups. Hazard ratio (HR) was applied to evaluate prognostic risk of age in different subgroups. Age-related DEGs were identified via RNA-seq data. Survival analysis was used to assess the relationship between DEGs and prognosis.

Results

In this study, we divided the patients into young (n=14276) and old (n=31698) subgroups according to cut-off value (age=53). Age >53 years was indicated as independent risk factor for overall survival (OS) and cancer specific survival (CSS) of CCRCC before and after PSM. The prognosis of old group was worse than that in young group. 176 age-related DEGs were obtained by 530 CCRCC RNA-seq analysis result. The expression levels of KCNE5, CLDN6 and CACNG6 were related to prognosis of the elderly.

Conclusion

53 years old was cut-off value in CCRCC. The prognosis of the elderly was worse than young people. KCNE5, CLDN6 and CACNG6 were age-related differential genes which might play an important role in the poor prognosis of elderly CCRCC patients.
Determinants of long acting reversible contraceptive Utilization in Bahir Dar city, Ethiopia-results from institutional based cross sectional study.
Authors: Ayenew Asteray Assmie , a amlaku mulat , m toyiba hiyaru 
Published: August 2019

Abstract
Background: Ethiopia is the second most populous country in Africa. Now a day, Adolescent sexual activity, unintended pregnancy, unsafe abortion, high maternal mortality and poverty has become a major issue in Ethiopia. The prevalence of contraceptive utilization is slanted to short acting. Methods: Institutional based cross-sectional study was conducted from public health facility in Bahir Dar City from April 1 to 30/2018. systematic sampling technique was used to select study participants and allocated to each public health institution proportionally. Data entry and analysis was made by using Epi info version 7 and SPSS versions 23 respectively. The association between the independent and outcome variables was first computed using bivariate analysis, p-value ≤0.25 was included into multivariable analysis. Finally, multivariable analyses were carried out with p-value≤ 0.05. Result: The overall utilization of long acting reversible contraception was 18.4%. Among the variables, desired number of children, women wish to have 0-3 number of children were 2.4times more likely to use long acting reversible contraceptives compared to those who want to have more than 4 children with (AOR=2.4:95%CI:1.22-4.8). Similarly, having good knowledge were found positively associated with long acting reversible contraceptive those who had good knowledge were 3 times (AOR=3:95%CI:1.52-5.9) more likely to utilize than those who had poor knowledge and also , favourable attitude were found to be positively associated with long acting reversible contraceptive methods utilization, women who had favourable attitude were 4.9 times more likely to utilize (AOR=4.9:95%CI:2.26-10.6) than those women’s who had unfavourable attitude. Conclusion: Utilization of long acting reversible contraceptive is low. Desired number of children, knowledge and attitude were determinant factors identified. So, Health education on long acting reversible contraceptives focusing on increasing women’s knowledge and attitude directed to women of reproductive age