bluuebunny/crossref_metadata_2025_split huggingface dataset:
The spectrum of spinal cord lesions in a primate model of multiple sclerosis
Authors: Lefeuvre Jennifer A , Guy Joseph R , Luciano Nicholas J , Ha Seung-Kwon , Leibovitch Emily , Santin Mathieu D , Silva Afonso C , Jacobson Steven , Lehéricy Stéphane , Reich Daniel S , Sati Pascal 
Published: February 2019

Background: Experimental autoimmune encephalomyelitis (EAE) in the common marmoset is a nonhuman primate model of multiple sclerosis (MS) that shares numerous clinical, radiological, and pathological features with MS. Among the clinical features are motor and sensory deficits that are highly suggestive of spinal cord (SC) damage. Objective: To characterize the extent and nature of SC damage in symptomatic marmosets with EAE using a combined magnetic resonance imaging (MRI) and histopathology approach. Materials and Methods: SC tissues from five animals were scanned using 7 T MRI to collect high-resolution ex vivo images. Lesions were segmented and classified based on shape, size, and distribution along the SC. Tissues were processed for histopathological characterization (myelin and microglia/macrophages). Statistical analysis, using linear mixed-effects models, evaluated the association between MRI and histopathology. Results: Marmosets with EAE displayed two types of SC lesions: focal and subpial lesions. Both lesion types were heterogeneous in size and configuration and corresponded to areas of marked demyelination with high density of inflammatory cells. Inside the lesions, the MRI signal was significantly correlated with myelin content ( p < 0.001). Conclusions: Our findings underscore the relevance of this nonhuman primate EAE model for better understanding mechanisms of MS lesion formation in the SC.
Evidence From a Long-Term, Systematic Post-Market Surveillance Program: Clinical Performance of a Hematocrit-Insensitive Blood Glucose Test Strip
Authors: Setford Steven , Phillips Stuart , Grady Mike 
Published: February 2019

Background: Described is a manufacturer’s systematic post-market evaluation of the long-term clinical accuracy of a commercially available blood glucose monitoring (BGM) test strip product. Methods: Production batches of test strips were routinely and regularly sampled and evaluated in a clinical setting to assess product accuracy. Evaluations were performed on capillary blood samples from a minimum of 100 subjects with diabetes, by clinical staff according to instructions for use. Readings were compared against capillary blood samples collected at the same time and measured by a standard laboratory reference method. Clinical accuracy was calculated according to EN ISO 15197:2015. Results: A total of 21 115 paired results were obtained, equating to 209 production batches over the >3-year period since test strip launch. Of the results, 97.6% met the accuracy criterion (range: 97.1-98.1% by year), with 98.1% of values presenting zero risk as defined by the surveillance error grid. At the <5th (21.0-33.8%) and >95th (48.3-59.4%) percentile extremes of hematocrit distribution, 97.9% and 96.4% of values were clinically accurate. The product also demonstrated clinical accuracy across all seven glucose ranges (“bins”) as defined by the standard. Under conditions of combined hematocrit and glucose (<80 mg/dL and ≥300 mg/dL) extremes, 97.7% of values were clinically accurate. Conclusions: Methodologies and results from a manufacturer’s self-imposed clinical accuracy surveillance program of a BGM product is presented. Given the publication of sometimes-conflicting data presented within ad hoc BGM clinical accuracy evaluations, usually of limited size, it is advocated that BGM manufacturers adopt similarly robust and systematic surveillance programs to safeguard patients.
Risk factors for atrial fibrillation in hypertrophic cardiomyopathy
Authors: Philipson Daniel J , Rader Florian , Siegel Robert J 
Published: February 2019

Abstract
Atrial fibrillation is the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM), occurring in approximately 25% of patients, which is four to six times more common than in similarly aged patients of the general population. Atrial fibrillation is poorly tolerated by HCM patients, largely due to their dependence on atrial systole for left ventricular filling. HCM patients who develop atrial fibrillation have an increased rate of heart failure related mortality and disabling or fatal thromboembolic events, as well as functional deterioration due to progressive heart failure when left untreated. Atrial fibrillation is both common in HCM and may lead to significant morbidity and mortality. Accurate risk stratification for atrial fibrillation in this population is crucial as contemporary treatments are highly successful. In this paper, we review the current understanding of known risk factors for atrial fibrillation, including different imaging-based parameters that assess left atrial structural and functional remodeling, electrocardiographic changes that reflect left atrial electrical remodeling, and a focus on comorbid obstructive sleep apnea, and in addition we review variables that have been reported to be predictive of atrial fibrillation. Last, we summarize the accumulating evidence for HCM patients having an intrinsic atrial myopathy.
The compliance rate for the second diagnostic evaluation after a positive fecal occult blood test: A systematic review and meta‐analysis
Authors: Gingold-Belfer Rachel , Leibovitzh Haim , Boltin Doron , Issa Nidal , Tsadok Perets Tsachi , Dickman Ram , Niv Yaron 
Published: February 2019

IntroductionOnly a minority of patients with a positive fecal occult blood test (FOBT) undergo a follow‐up second diagnostic procedure, thus minimizing its contribution for colorectal cancer (CRC) prevention. We aimed to obtain a precise estimation of this problem and also assess the diagnostic yield of CRC and adenomas by colonoscopy in these patients.MethodsLiterature searches were conducted for “compliance” OR “adherence” AND “fecal occult blood test” OR “fecal immunohistochemical test” AND “colonoscopy.” Comprehensive meta‐analysis software was used.ResultsThe search resulted in 42 studies (512,496 patients with positive FOBT), published through December 31, 2017. A funnel plot demonstrates a moderate publication bias. Compliance with any second procedure, colonoscopy, or combination of double‐contrast barium enema with or without sigmoidoscopy in patients with a positive FOBT was 0.725 with 95% confidence interval (CI) 0.649–0.790 (p = 0.000), 0.804 with 95% CI 0.740–0.856 (p = 0.000) and 0.197 with 95% CI 0.096–0.361 (p = 0.000), respectively. The diagnostic yield for CRC, advanced adenoma and simple adenoma was 0.058 with 95% CI 0.050–0.068 (p = 0.000), 0.242 with 95% CI 0.188–0.306 (p = 0.000) and 0.147 with 95% CI 0.116–0.184 (p < 0.001), respectively.DiscussionCompliance with diagnostic evaluation after a positive FOBT is still suboptimal. Therefore, measures to increase compliance need to be taken given the increased risk of CRC in these patients.
Feasibility of designing, manufacturing and delivering 3D printed ankle‐foot orthoses: a systematic review
Authors: Wojciechowski Elizabeth , Chang Angela Y. , Balassone Daniel , Ford Jacqueline , Cheng Tegan L. , Little David , Menezes Manoj P. , Hogan Sean , Burns Joshua 
Published: February 2019

AbstractBackgroundAnkle‐foot orthoses (AFO) are prescribed to manage difficulty walking due to foot drop, bony foot deformities and poor balance. Traditional AFOs are handmade using thermoplastic vacuum forming which provides limited design options, is labour‐intensive and associated with long wait times. 3D printing has the potential to transform AFO production and health service delivery. The aim of this systematic review was to determine the feasibility of designing, manufacturing and delivering customised 3D printed AFOs by evaluating the biomechanical outcomes, mechanical properties and fit of 3D printed compared to traditionally manufactured AFOs.MethodElectronic databases were searched from January 1985 to June 2018 according to terms related to 3D printing and AFOs. Studies of any design from healthy or pathological populations of any age were eligible for inclusion. Studies must have investigated the effect of customised 3D printed AFOs using any 3D printing technique on outcomes related to walking ability, biomechanical function, mechanical properties, patient comfort, pain and disability. Any other orthotic type or AFOs without a 3D printed calf and foot section were excluded. The quality of evidence was assessed using the GRADE process.ResultsEleven studies met the eligibility criteria evaluating 3D printed AFOs in healthy adults, and adults and children with unilateral foot drop from a variety of conditions. 3D printing was used to replicate traditional AFOs and develop novel designs to optimise the stiffness properties or reduce the weight and improve the ease of use of the AFO. 3D printed custom AFOs were found to be comparable to traditional custom AFOs and prefabricated AFOs in terms of temporal‐spatial parameters. The mechanical stiffness and energy dissipation of 3D printed AFOs were found to be similar to prefabricated carbon‐fibre AFOs. However, the sample sizes were small (n = 1 to 8) and study quality was generally low.ConclusionThe biomechanical effects and mechanical properties of 3D printed AFOs were comparable to traditionally manufactured AFOs. Developing novel AFO designs using 3D printing has many potential benefits including stiffness and weight optimisation to improve biomechanical function and comfort.
Real-time 3D Photoacoustic Visualization System with a Wide Field of View for Imaging Human Limbs
Authors: Nagae Kenichi , Asao Yasufumi , Sudo Yoshiaki , Murayama Naoyuki , Tanaka Yuusuke , Ohira Katsumi , Ishida Yoshihiro , Otsuka Atsushi , Matsumoto Yoshiaki , Saito Susumu , Furu Moritoshi , Murata Koichi , Sekiguchi Hiroyuki , Kataoka Masako , Yoshikawa Aya , Ishii Tomoko , Togashi Kaori , Shiina Tsuyoshi , Kabashima Kenji , Toi Masakazu , Yagi Takayuki 
Published: February 2019

Background: A breast-specific photoacoustic imaging (PAI) system prototype equipped with a hemispherical detector array (HDA) has been reported as a promising system configuration for providing high morphological reproducibility for vascular structures in living bodies. Methods: To image the vasculature of human limbs, a newly designed PAI system prototype (PAI-05) with an HDA with a higher density sensor arrangement was developed. The basic device configuration mimicked that of a previously reported breast-specific PAI system. A new imaging table and a holding tray for imaging a subject's limb were adopted. Results: The device’s performance was verified using a phantom. Contrast of 8.5 was obtained at a depth of 2 cm, and the viewing angle reached up to 70 degrees, showing sufficient performance for limb imaging. An arbitrary wavelength was set, and a reasonable PA signal intensity dependent on the wavelength was obtained. To prove the concept of imaging human limbs, various parts of the subject were scanned. High-quality still images of a living human with a wider size than that previously reported were obtained by scanning within the horizontal plane and averaging the images. The maximum field of view (FOV) was 270 mm × 180 mm. Even in movie mode, one-shot 3D volumetric data were obtained in an FOV range of 20 mm in diameter, which is larger than values in previous reports. By continuously acquiring these images, we were able to produce motion pictures. Conclusion: We developed a PAI prototype system equipped with an HDA suitable for imaging limbs. As a result, the subject could be scanned over a wide range while in a more comfortable position, and high-quality still images and motion pictures could be obtained.
The Impact of Time Shifting on TV Consumption and Ad Viewership
Authors: Belo Rodrigo , Ferreira Pedro , Godinho de Matos Miguel , Reis Filipa 
Published: February 2019

In this paper we study the impact of time shifting on TV consumption and ad viewership. We analyze the results of a field experiment in which a random sample of “triple-play” households were given a set of premium TV channels broadcasting popular movies and TV shows without commercial breaks. A random subset of these households were given access to these channels with time shifting (automated cloud recording for later viewing or rewinding of broadcasted programs), while the remainder were not. This design allowed us to identify the effects of time shifting on TV consumption. On average, we found that receiving access to the channels with time shifting increased total TV consumption because it increased time-shifted viewership while leaving live viewership unchanged. The increase in the live viewership of these channels was similar to the reduction in the live viewership of the originally available channels, resulting in a net zero effect on live viewership. It appears that time shifting does not change the concentration of live viewership, but it does increase the concentration of total TV viewership, because it is used disproportionately to watch the most popular programs. Finally, we found that time shifting does not change the likelihood of skipping ads during live viewership, suggesting that households do not use time shifting to strategically avoid ads. The online appendix is available at https://doi.org/10.1287/mnsc.2018.3084 . This paper was accepted by Matthew Shum, marketing.
The dance goes on: Following in the footsteps of Rosemary Butcher
Authors: Bannerman Henrietta 
Published: February 2019

Abstract
This article concerns Lauren Potter’s Frames for Falling (2017c),1 a fifteen-minute work for eleven students graduating from London Contemporary Dance School (LCDS), and for which the stimulus was Rosemary Butcher’s Still-Slow-Divided (2002). I trace the artistic and creative background that gave rise to this dance by registering milestones in Rosemary Butcher’s career and investigating her choreographic practice that, echoing the German academic Pirkko Husemann, I define as a ‘critical practice’. Writing from the perspective of practice as research, I chart Potter’s process in the studio when, in the summer of 2017, she created her new dance. Included in the article is interview material from Nigel Butcher, Potter, and one of the participating students, Ryan Jones. There is also a brief sketch of Frames for Falling as it was performed in the Robin Howard Dance Theatre in July 2017. I conclude the article by arguing that under Potter’s expert practical guidance and deep knowledge of Butcher’s choreographic process, the LCDS students engaged in a new form of dance history, studying it as they did in the context of physical studio practice.
Music making and the potential impact for a child in foster care
Authors: Humphrey Ryan 
Published: February 2019

Abstract
The United Kingdom has seen an increasing number of children entering the looked after care system (foster care, adoptive care or residential care). Due to this increasing number, there have been several music projects set up in the United Kingdom, which aim to provide opportunities for musical engagement for looked after children. This article aims to examine the impact that a music project has on children in foster care and their carers. Using a case study strategy to examine the Loud and Clear project based at Sage Gateshead, this research took on a multi-methodological approach. Focus groups and interviews were constructed to collect the narratives of participants’ experiences of attending the project and to identify the impacts the project may be having. Additionally, participatory observations were also undertaken to see first-hand the approaches that the facilitators were using within sessions to meet the needs of the participants. Findings indicated that attending a music project helped facilitate a sense of structure for foster children while also providing unique opportunities for carers to socialize with one another – these being two key areas that are often lacking in participants’ lives, that can be seen to be overcome through active participation within a music project.
Un écrit inédit d’Henry Bauchau : la « traduction » d’une idée préliminaire pour Œdipe sur la route
Authors: MASTROIANNI Michèle 
Published: February 2019

Michele Mastroianni s’interroge sur ce que signifie Henry Bauchau lorsqu’il se dit « le traducteur infidèle » de quelque chose qui a voulu parler à travers lui dans le moment de l’inspiration. Pour ce faire, il analyse comparativement la première et la deuxième version d’Œdipe sur la route, sur le plan des variations lexicales et syntagmatiques. L’analyse structurelle révèle les mécanismes d’intratextualité propres à l’écrivain, et repère cinq mouvements fondamentaux dans son processus d’écriture.
La présence du rêve dans les journaux personnels d’Henry Bauchau
Authors: PIBAROT Annie 
Published: February 2019

L’article fait le point sur la présence des récits de rêve dans l’ensemble diariste de cet écrivain psychanalyste qu’est Henry Bauchau : leur fréquence, leur mode d’annonce, leurs contenus récurrents, leur fonction et leur statut : avant-textes, textes-origine, ou déjà séquences littéraires à part entière, faisant droit à une pensée par images et autorisant un autre type de temporalité.
Les échos d’Antigone. De la voix au visage
Authors: SIFFERT Elsa 
Published: February 2019

Analyse de l’opéra La lumière Antigone se référant aux théories de Lacan. L’ensemble de la production littéraire d’Henry Bauchau est traversé de multiples voix. Parmi elles, plus spécifiquement, une voix sans parole qui n’est pas un vecteur de communication, mais véhicule d’un désir de l’Autre. Cette voix qui exprime l’indicible, est paradoxalement mise en mot dans le dialogue d’Antigone et d’Hannah et trouve un écho dans la musique. «Bauchau intègre le cri d’Antigone, cette poussée extime d’un informulé informulable et agrammatical qui demande pourtant à se manifester. Pierre Bartholomée offre à ce cri, à cette parole Antigone, un monde musical. »
L’archive, devenir et avenir de l’œuvre d’Henry Bauchau
Authors: MAYAUX Catherine 
Published: February 2019

L’abondance des ébauches théâtrales conservées dans les archives d’Henry Bauchau amène à considérer trois aspects encore sous-estimés dans l’approche de son œuvre. En premier lieu, sa fascination pour la forme dramatique, épique notamment, mais non suivie d’effets, rappelle que l’auteur aurait voulu être un homme d’action sans réussir dans cette voie. En second lieu, cette partie spectrale ou fantomale de son œuvre entre dans les contours de l’œuvre complète : cette inventivité dramatique, que l’on retrouve dans les autres genres pratiqués, se manifeste dans la théâtralité romanesque ou poétique. Enfin, le 3ème aspect met en évidence l’importance de la voix, intérieure notamment, qui crée différents niveaux de parole et d’écoute.
The Motivations behind Child Welfare Work
Authors: Dickman Samuel J 
Published: February 2019

This report seeks to explore the findings of a qualitative research study concerning the motivations behind child welfare work. Child welfare is a major field within the social work profession that demands a great deal of expertise and effort from workers. Professionals employed as case managers within the child welfare field are held accountable for a wide variety of social work roles, often placing these individuals at risk of emotional trauma and high levels of work-related stress. Due to this, workers who remain in the field for extensive periods of time often experience strong sensations of purpose relative to their work. Our study found that child welfare caseworkers were motivated by altruism and a deep desire to improve the lives of their clients. They were also kept motivated by the successes that came from time to time. While trials seem to be experienced on a regular basis, child welfare caseworkers generally found their work to be a positive presence within the families they serve. Further research is needed to expound upon the findings of this study.
Developing Faculty Communities of Practice to Expand the Use of Effective Pedagogical Techniques
Authors: Hoyert Mark , O'Dell Cynthia 
Published: February 2019

The scholarship of teaching and learning literature is replete with examples of pedagogical techniques that have been demonstrated to be effective in improving learning, motivation, and student success. The extension of these techniques beyond the original context has tended to be slow, difficult, and incomplete. The following paper examines an intervention designed to encourage the exploration and use of a variety of pedagogical techniques by faculty in a traditional, four-year college faculty within the context of the AASCU Re-imagining the First Year Initiative. Small groups of six to eight faculty, joined and created communities of practice. The groups were known as Pedagogical Interest Groups, or PIGs for short. The faculty read about and analyzed a series of pedagogical techniques and committed to introducing at least one technique into their courses to further explore the techniques. When the techniques were successful, the faculty members redesigned entire classes to expand the impact. The communities of practice were successful in encouraging faculty to explore a wide variety of techniques. The average faculty group explored eight different pedagogical techniques. Faculty were able to use the opportunity to experiment with techniques with the support from their colleagues in their PIG. A dozen techniques were explored across the PIGs and dozens of class sections have been completely redesigned. To date, over 2000 students have experienced redesigned courses. Measures of student success, satisfaction, and interest in those sections have increased. The effort has been accompanied by a robust increase in the campus-wide retention rates. ​
Morita homotopy theory for (∞,1)-categories and ∞-operads
Authors: Caviglia Giovanni , Gutiérrez Javier J. 
Published: February 2019

Abstract
We prove the existence of Morita model structures on the categories of small simplicial categories, simplicial sets, simplicial operads and dendroidal sets, modelling the Morita homotopy theory of

(
∞
,
1
)

{(\infty,1)}

-categories and

∞

{\infty}

-operads. We give a characterization of the weak equivalences in terms of simplicial presheaves, simplicial algebras and slice categories. In the case of the Morita model structure for simplicial categories and simplicial operads, we also show that each of these model structures can be obtained as an explicit left Bousfield localization of the Bergner model structure on simplicial categories and the Cisinski–Moerdijk model structure on simplicial operads, respectively.