bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carina Bifurcation Angle and Side Branch Occlusion in Coronary Bifurcation Lesions Intervention: Angiographic Lesions Characteristic Role in Determining Its Relation
Authors: Palinggi Bogie Putra , Firman Doni 
Published: November 2018

AbstractSide branch occlusion has been implicated as a complication after percutaneous coronary intervention in coronary bifurcation lesions. The role of carina bifurcation angle as one of the characteristics of the coronary bifurcation lesions in causing side branch occlusion after percutaneous coronary intervention is still debated. This study aims to assess the correlation between carina bifurcation angles as one of the characteristics of the coronary bifurcation lesions and side branch occlusion in elective percutaneous coronary intervention. This is a cross-sectional study which utilizes CAAS 5.1 software to measure carina bifurcation angle. We collected 113 lesions in 108 patients that met the inclusion criteria from January 2016 to October 2016. Side branch occlusion occurred in 15 lesions (13.3%), with median carina bifurcation angle 19.17 degrees (p < 0.001). Multivariate analysis showed there is a correlation between carina bifurcation angle with side branch occlusion, OR (odds ratio) 0.86 (95% CI [confidence interval]: 0.80–0.92) with ≤ 33.71 degrees cut off value. Increased risk of side branch occlusion was found in small carina bifurcation angle.
Frames change in language contact environments
Authors: Hünlich David 
Published: November 2018

Abstract
Based on the empirical data of 97 fourth-graders from three districts of Braunschweig in Germany, this paper investigates the possibility of changing semantic frames in multilingual communities. The focus of study is the verb field of self-motion. In a free-sorting task involving 52 verbs, Turkish-speaking students, in particular, placed the verbs schleichen (‘to sneak’) and kommen (‘to come’) in the same group. When explaining the perceived similarity they also used the word schleichen (‘to sneak’), in a specific grammatical construction that is not found in Standard German. This paper suggests that semantic frames may change along with grammatical constructions when typologically distinct languages come into close contact.
The Relationship between Farm Size and Productivity in Agriculture: Evidence from Maize Production in Northern China
Authors: Sheng Yu , Ding Jiping , Huang Jikun 
Published: November 2018

AbstractThe relationship between farm size and productivity has long been a topic of debate in development economics. Using farm‐level panel data from 2003 to 2013, we investigate the relationship between maize yield and farm size in Northern China. After controlling for farm‐specific characteristics, we restore a mild U‐shaped relationship between maize yield and cropping area from the apparent inverse U‐shaped curve. This suggests that an inverse farm size–productivity relationship persists for most small‐sized farms. Further analyses demonstrate that farmer input choice between labor and capital is likely to smooth the non‐linear farm size–productivity relationship, with capital use being more likely to affect the farm size–productivity relationship at a larger scale. The findings imply that subsidizing farmers to rent land without helping them become better‐equipped could result in resource misallocation towards larger farms using less‐efficient labor‐intensive technologies.
Arterial Stiffness and Blood Pressure in a Multicultural Child Sample (Angola, Brazil, and Spain)
Authors: Montero López M Pilar , Mora-Urda Ana Isabel , Mill José Geraldo , Silva Amílcar B T , Santos Batista Milena , B Molina Maria del Carmen 
Published: November 2018

Abstract

BACKGROUND
To analyze the relationship between early-life indicators, blood pressure (BP), and arterial stiffness in childhood, in three samples with different bio-cultural characteristics.

METHODS
The total sample included 520 schoolchildren 9–10 years of age from Madrid (Spain), Vitória (Brazil), and Luanda (Angola). Height and weight, BP, and carotid-femoral pulse wave velocity (cf-PWV) were measured, all by one observer in each site, and body mass index (BMI) was calculated. Birth weight, gestational age, type of feeding, and age at weaning were extracted from official health cards. Data were analyzed by multiple linear regression models.

RESULTS
No significant differences were observed in systolic blood pressure (SBP) and diastolic blood pressure (DBP) among the samples (P = 0.107 and P = 0.808). Luanda showed the higher cf-PWV (5.7 m/s), followed by Vitória (5.3 m/s) and Madrid (4.9 m/s; P &lt; 0.001). Explanatory factors for the observed variability in SBP, DBP, and cf-PWV, obtained by means of multiple linear regression models, were different in three samples. BMI showed a positive and significant association with SBP, DBP, and cf-PWV in three samples. In the Angolan sample, in addition to BMI, birth weight was maintained in the explanatory models of SBP and cf-PWV adjusted for BP, with a negative and significant coefficient (−0.019 and −0.019)

CONCLUSIONS
Higher values of BMI in childhood are related with higher values of cf-PWV, SBP, and DBP in the three samples. Children from Angola showed the highest mean value of cf-PWV, especially those who had lower birth weight, suggesting that worse conditions in fetal life may contribute to increased aortic stiffness in childhood.
Heterozygous Tsc2 (Tsc2+/–) mouse model to study induced renal cancer in response to ionizing radiation at low doses
Authors: M A Sureshkumar , Delma Caroline R , Manickam Krishnan , Mohan Sumathy , Habib Samy L , Natarajan Mohan 
Published: November 2018

Abstract
Kidneys are one of the main dose-limiting organs in radiotherapeutic procedures of lower abdomen. Likewise, the threat of exposure of radiosensitive organs such as kidneys in warfare or radiation accidents among military personal or due to terrorist activities in general public is of increasing concern. These events warrant the need for appropriate animal models to study the acute and chronic effects of low- and high-dose rate radiation exposures. In this study, for the first time, we validated Tsc2+/– mouse model to study whether radiation accelerates carcinogenesis in kidneys. Tsc2+/– mice at increasing age groups at 8 and 10 months were exposed to repeated doses of gamma radiation (0.4 Gy × 5) and assessed for aggravated kidney tumor formation at 2 months post-irradiation. Animals from irradiated group showed a significant increase in numbers of bilateral, multifocal tumors compared with mock-irradiated animals. Intra-glomerular reactive oxygen species (ROS) levels measured by dihydroethidium florescence showed significant increases in ROS production in irradiated Tsc2+/– mice compared with non-irradiated animals. Similarly, selective hematological parameters and glomerular filtration rate were further reduced significantly in irradiated Tsc2+/– mice. Tsc2 protein, tuberin in irradiated mice, however, remains at the same reduced levels as that of the mock-irradiated heterozygous Tsc2 mice. The results indicate that radiation alters kidney homeostatic function and influences high spontaneous incidence of renal cell carcinoma in this rodent model. Repurposing of Tsc2+/– mice model will, therefore, provide a unique opportunity to study acute and delayed effects of radiation in the development of kidney cancers.
I See Your Effort: Force-Related BOLD Effects in an Extended Action Execution–Observation Network Involving the Cerebellum
Authors: Casiraghi Letizia , Alahmadi Adnan A S , Monteverdi Anita , Palesi Fulvia , Castellazzi Gloria , Savini Giovanni , Friston Karl , Gandini Wheeler-Kingshott Claudia A M , D’Angelo Egidio 
Published: November 2018

AbstractAction observation (AO) is crucial for motor planning, imitation learning, and social interaction, but it is not clear whether and how an action execution–observation network (AEON) processes the effort of others engaged in performing actions. In this functional magnetic resonance imaging (fMRI) study, we used a “squeeze ball” task involving different grip forces to investigate whether AEON activation showed similar patterns when executing the task or observing others performing it. Both in action execution, AE (subjects performed the visuomotor task) and action observation, AO (subjects watched a video of the task being performed by someone else), the fMRI signal was detected in cerebral and cerebellar regions. These responses showed various relationships with force mapping onto specific areas of the sensorimotor and cognitive systems. Conjunction analysis of AE and AO was repeated for the “0th” order and linear and nonlinear responses, and revealed multiple AEON nodes remapping the detection of actions, and also effort, of another person onto the observer’s own cerebrocerebellar system. This result implies that the AEON exploits the cerebellum, which is known to process sensorimotor predictions and simulations, performing an internal assessment of forces and integrating information into high-level schemes, providing a crucial substrate for action imitation.
Quantifying How Different Clinical Presentations, Levels of Severity, and Healthcare Attendance Shape the Burden of Influenza-associated Illness: A Modeling Study From South Africa
Authors: Tempia Stefano , Walaza Sibongile , Moyes Jocelyn , Cohen Adam L , McMorrow Meredith L , Treurnicht Florette K , Hellferscee Orienka , Wolter Nicole , von Gottberg Anne , Nguweneza Arthemon , McAnerney Johanna M , Dawood Halima , Variava Ebrahim , Madhi Shabir A , Cohen Cheryl 
Published: November 2018

AbstractBackgroundBurden estimates of medically and nonmedically attended influenza-associated illness across syndromes and levels of severity are lacking.MethodsWe estimated the national burden of medically and nonmedically attended influenza-associated illness among individuals with different clinical presentations (all-respiratory, all-circulatory, and nonrespiratory/noncirculatory) and levels of severity (mild, fatal, and severe, nonfatal) using a combination of case-based (from laboratory-confirmed influenza surveillance) and ecological studies, as well as data from healthcare utilization surveys in South Africa during 2013–2015. In addition, we compared estimates of medically attended influenza-associated respiratory illness, obtained from case-based and ecological studies. Rates were reported per 100 000 individuals in the population.ResultsThe estimated mean annual number of influenza-associated illness episodes was 10 737 847 (19.8% of 54 096 705 inhabitants). Of these episodes, 10 598 138 (98.7%) were mild, 128 173 (1.2%) were severe, nonfatal, and 11 536 (0.1%) were fatal. There were 2 718 140 (25.6%) mild, 56 226 (43.9%) severe, nonfatal, and 4945 (42.8%) medically attended should be after fatal episodes. Influenza-associated respiratory illness accounted for 99.2% (10 576 146) of any mild, 65.5% (83 941) of any severe, nonfatal, and 33.7% (3893) of any fatal illnesses. Ecological and case-based estimates of medically attended, influenza-associated, respiratory mild (rates: ecological, 1778.8, vs case-based, 1703.3; difference, 4.4%), severe, nonfatal (rates: ecological, 88.6, vs case-based, 75.3; difference, 15.0%), and fatal (rates: ecological, 3.8, vs case-based, 3.5; difference, 8.4%) illnesses were similar.ConclusionsThere was a substantial burden of influenza-associated symptomatic illness, including severe, nonfatal and fatal illnesses, and a large proportion was nonmedically attended. Estimates, including only influenza-associated respiratory illness, substantially underestimated influenza-associated, severe, nonfatal and fatal illnesses. Ecological and case-based estimates were found to be similar for the compared categories.
Criteria2Query: a natural language interface to clinical databases for cohort definition
Authors: Yuan Chi , Ryan Patrick B , Ta Casey , Guo Yixuan , Li Ziran , Hardin Jill , Makadia Rupa , Jin Peng , Shang Ning , Kang Tian , Weng Chunhua 
Published: November 2018

AbstractObjectiveCohort definition is a bottleneck for conducting clinical research and depends on subjective decisions by domain experts. Data-driven cohort definition is appealing but requires substantial knowledge of terminologies and clinical data models. Criteria2Query is a natural language interface that facilitates human-computer collaboration for cohort definition and execution using clinical databases.Materials and MethodsCriteria2Query uses a hybrid information extraction pipeline combining machine learning and rule-based methods to systematically parse eligibility criteria text, transforms it first into a structured criteria representation and next into sharable and executable clinical data queries represented as SQL queries conforming to the OMOP Common Data Model. Users can interactively review, refine, and execute queries in the ATLAS web application. To test effectiveness, we evaluated 125 criteria across different disease domains from ClinicalTrials.gov and 52 user-entered criteria. We evaluated F1 score and accuracy against 2 domain experts and calculated the average computation time for fully automated query formulation. We conducted an anonymous survey evaluating usability.ResultsCriteria2Query achieved 0.795 and 0.805 F1 score for entity recognition and relation extraction, respectively. Accuracies for negation detection, logic detection, entity normalization, and attribute normalization were 0.984, 0.864, 0.514 and 0.793, respectively. Fully automatic query formulation took 1.22 seconds/criterion. More than 80% (11+ of 13) of users would use Criteria2Query in their future cohort definition tasks.ConclusionsWe contribute a novel natural language interface to clinical databases. It is open source and supports fully automated and interactive modes for autonomous data-driven cohort definition by researchers with minimal human effort. We demonstrate its promising user friendliness and usability.
Speech recognition for clinical documentation from 1990 to 2018: a systematic review
Authors: Blackley Suzanne V , Huynh Jessica , Wang Liqin , Korach Zfania , Zhou Li 
Published: November 2018

AbstractObjectiveThe study sought to review recent literature regarding use of speech recognition (SR) technology for clinical documentation and to understand the impact of SR on document accuracy, provider efficiency, institutional cost, and more.Materials and MethodsWe searched 10 scientific and medical literature databases to find articles about clinician use of SR for documentation published between January 1, 1990, and October 15, 2018. We annotated included articles with their research topic(s), medical domain(s), and SR system(s) evaluated and analyzed the results.ResultsOne hundred twenty-two articles were included. Forty-eight (39.3%) involved the radiology department exclusively and 10 (8.2%) involved emergency medicine; 10 (8.2%) mentioned multiple departments. Forty-eight (39.3%) articles studied productivity; 20 (16.4%) studied the effect of SR on documentation time, with mixed findings. Decreased turnaround time was reported in all 19 (15.6%) studies in which it was evaluated. Twenty-nine (23.8%) studies conducted error analyses, though various evaluation metrics were used. Reported percentage of documents with errors ranged from 4.8% to 71%; reported word error rates ranged from 7.4% to 38.7%. Seven (5.7%) studies assessed documentation-associated costs; 5 reported decreases and 2 reported increases. Many studies (44.3%) used products by Nuance Communications. Other vendors included IBM (9.0%) and Philips (6.6%); 7 (5.7%) used self-developed systems.ConclusionDespite widespread use of SR for clinical documentation, research on this topic remains largely heterogeneous, often using different evaluation metrics with mixed findings. Further, that SR-assisted documentation has become increasingly common in clinical settings beyond radiology warrants further investigation of its use and effectiveness in these settings.
Determining Frankliniella fusca (Thysanoptera: Thripidae) Egg Distribution in Neonicotinoid Seed-Treated Cotton
Authors: D’Ambrosio Damon A , Huseth Anders S , Kennedy George G 
Published: November 2018

Abstract
Frankliniella fusca (Hinds) (Thysanoptera: Thripidae) is an early-season cotton pest. Seedlings are injured by larvae, which hatch from eggs oviposited into seedlings and feed on developing plant tissue. Better understanding F. fusca oviposition in cotton may improve their management and address new challenges such as resistance to neonicotinoid seed treatments (NSTs). Cotton seedlings exposed to F. fusca were either cleared and stained to determine egg density and location, or dissected and washed to determine larval distribution. Experiments were conducted in the greenhouse with a susceptible population and field with a NST-resistant population. Eggs of both populations were recovered predominantly in cotyledons. Larvae were more uniformly distributed on seedlings. On NST seedlings, oviposition by the susceptible population was reduced and preference shifted to true leaves. NSTs did not alter egg placement by the resistant population. These findings suggest that injury to cotton seedlings is primarily caused by F. fusca emerging on the cotyledons, and then moving to developing leaves. The oviposition shift in NST plants correlates with how systemic NSTs have been reported to concentrate in cotyledons. This can better inform management tactics in cotton, such as well-timed foliar sprays, which, given the current resistance issue, are needed to maintain effective thrips management.
Correcting HIRES/Keck radial velocities for small systematic errors
Authors: Tal-Or Lev , Trifonov Trifon , Zucker Shay , Mazeh Tsevi , Zechmeister Mathias 
Published: November 2018

ABSTRACT
The HIRES spectrograph, mounted on the 10-m Keck-I telescope, belongs to a small group of radial-velocity (RV) instruments that produce stellar RVs with long-term precision down to ∼1 m s−1. In 2017, the HIRES team published 64,480 RVs of 1699 stars, collected between 1996 and 2014. In this bank of RVs, we identify a sample of RV-quiet stars, whose RV scatter is &lt;10 m s−1, and use them to reveal two small but significant nightly zero-point effects: a discontinuous jump, caused by major modifications of the instrument in August 2004, and a long-term drift. The size of the 2004 jump is 1.5 ± 0.1 m s−1, and the slow zero-point variations have a typical magnitude of ≲ 1 m s−1. In addition, we find a small but significant correlation between stellar RVs and the time relative to local midnight, indicative of an average intra-night drift of 0.051 ± 0.004 m s−1 h−1. We correct the 64 480 HIRES RVs for the systematic effects we find, and make the corrected RVs publicly available. Our findings demonstrate the importance of observing RV-quiet stars, even in the era of simultaneously-calibrated RV spectrographs. We hope that the corrected HIRES RVs will facilitate the search for new planet candidates around the observed stars.
Hunter Syndrome
Authors: Joseph Rachel , DiCesare Emily B. , Miller Amy 
Published: November 2018

Background:
Hunter syndrome, or mucopolysaccharidosis type II (MPS II), is a lysosomal storage disease that affects the breakdown of sugar in the body. Research has made it possible to reveal the cause of the disease, thus helping diagnose and treating this rare disorder. Enzyme replacement therapy will help children live longer and healthier lives.

Purpose:
The purpose of this literature review is to explore the existing knowledge on MPS II and to inform the nursing community about the prevalence of MPS II and examine why it is important to offer screening to parents of a newborn or child.

Search Strategy:
CINAHL, PubMed, Cochrane, and Google Scholar were searched using the key words to find publications in English on MPS II during 2009 to 2018.

Findings:
Early detection is key for successful management of MPS II. Early initiation of enzyme replacement therapy will enhance the health of children. Support groups advocate for services for the children and their families.

Implications for Practice:
Earlier initiation of treatment leads to better outcomes, and healthcare providers should advocate for including MPS II in newborn screening. Families should be offered genetic counseling and support services.

Implications for Research:
More research is essential to identify the long-term effects on families and the effect of enzyme replacement therapy on children with MPS II.

Conclusion:
The birth of a child with the rare disorder such as MPS II will change the lives of families forever. Early identification and treatment can slow down decline in health and improve quality of life of children and their families.
Outcomes and Characteristics of Patients Receiving Second-line Therapy for Advanced Pancreatic Cancer
Authors: Tsang Erica S. , Wong Hui-li , Wang Ying , Renouf Daniel J. , Cheung Winson Y. , Lim Howard J. , Gill Sharlene , Loree Jonathan M. , Kennecke Hagen F. 
Published: November 2018

Objectives:
There is limited randomized data to guide second-line chemotherapy selection in advanced pancreatic cancer (APC). We aimed to characterize predictors and outcomes of second-line chemotherapy in patients with APC.

Methods:
We identified all patients with APC [locally advanced (LAPC) or metastatic (MPC)] who received ≥1 cycle of first-line chemotherapy between January 2012 and December 2015 across 6 cancer centers in British Columbia, Canada. Baseline characteristics and survival outcomes were summarized.

Results:
Of 676 patients with APC (31% LAPC, 69% MPC) who received ≥1 cycle of chemotherapy, 164 (24%) received second-line chemotherapy. These patients were younger, with lower ECOG and higher CA19-9 at presentation, compared with patients who did not receive second-line chemotherapy. There were no differences in rates of second-line chemotherapy between LAPC and MPC (28% vs. 23%; P=0.18). Only first-line FOLFIRINOX was associated with second-line chemotherapy. Median overall survival (OS) from second-line chemotherapy was longer with second-line gemcitabine/nab-paclitaxel than fluoropyrimidine or gemcitabine (7.9 vs. 5.1 vs. 4.3 mo; P=0.008). On multivariable analysis, longer OS from second-line chemotherapy was associated with gemcitabine/nab-paclitaxel, lower ECOG, and LAPC.

Conclusions:
In this population-based cohort, first-line FOLFIRINOX was the strongest predictor of second-line chemotherapy. Duration of therapy remains short and novel treatments are urgently needed.