bluuebunny/crossref_metadata_2025_split huggingface dataset:
The periodic table – an experimenter’s guide to transactinide chemistry
Authors: Eichler Robert 
Published: March 2019

Abstract
The fundamental principles of the periodic table guide the research and development of the challenging experiments with transactinide elements. This guidance is elucidated together with experimental results from gas phase chemical studies of the transactinide elements with the atomic numbers 104–108 and 112–114. Some deduced chemical properties of these superheavy elements are presented here in conjunction with trends established by the periodic table. Finally, prospects are presented for further chemical investigations of transactinides based on trends in the periodic table.
Costly Voluntary Disclosure in a Signaling Game
Authors: Pecorino Paul , Van Boening Mark 
Published: March 2019

Abstract
We conduct an experimental analysis of pretrial bargaining, while allowing for the costly disclosure of private information in a signaling game. Under the theory, 100 % of plaintiffs with a weak case are predicted to remain silent, while 100 % of the plaintiffs with a strong case are predicted to voluntarily disclose their type. We find that 75 % of weak plaintiffs remain silent and 67 % of strong plaintiffs reveal their type. In line with theory, weak plaintiffs who reveal their type receive a lower payoff, while strong plaintiffs who reveal their type receive a higher payoff. Plaintiffs with a strong case who reveal their type have a dispute rate which is 50 % points lower than strong plaintiffs who remain silent. Because plaintiffs who reveal their type cannot extract the entire surplus from settlement from the defendant, the incentive to engage in voluntary disclosure is weaker empirically than it is in theory.
Targeting epidermal growth factor receptor pathway with irreversible tyrosine kinase inhibitor
Authors: Sagir Fatma , Demiroglu-Zergeroglu Asuman 
Published: March 2019

Abstract

Background
Malignant mesothelioma (MM) is an endemic disease around central Anatolia region in Turkey, where people are exposed to erionite- and asbestos-contaminated soil. Aberrant EGFR signalling has implicated in several cancers including MMs. Tyrosine kinase inhibitors are new treatment options harbouring deregulated signalling network components. In this study, we aimed to investigate anti-proliferative effect of CL-387,785 in MM cells.

Materials and methods
Alteration of cell proliferation was evaluated with using MTS assay. Profile of EGFR, ERK, AKT, JNK and p38 proteins and ELK-1, JUN, STAT1, STAT3 and STAT5 genes were analysed by western blot and RT-PCR, respectively.

Results
Viability of MM cells was inhibited in dose- and time-dependent manner. CL-387,785 affected MM cells earlier and at higher extent compared to the mesothelial cells. CL-387,785 treatments suppressed EGF-induced phosphorylation of EGFR, ERK, AKT, STAT3 and STAT5 but not SAPK/JNK and p38 in SPC212 cells. RT-PCR analysis showed that expression of p21 increased, while Cyclin D and c-jun expressions decreased in SPC212 cells. However, ELK-1, STAT3 and STAT5, expressions did not change.

Conclusion
Our results propose that CL-387,785 could be an efficacious agent in the treatment of MMs with uncontrolled EGFR signalling.
IVSII-74 T>G: As harmless as we thought?
Authors: Hocaoglu-Emre F. Sinem , Yenmis Guven , Saribal Devrim , Yakicier Cengiz 
Published: March 2019

Abstract

Background
IVSII-74 T > G is one of the most frequently identified polymorphic sites on the β-globin gene. In our report, we present three cases with low mean corpuscular volume (MCV) value in three and high red blood cell (RBC) value in two of the cases. The objective of this study was to further analyse the reason for condition of three patients, who were referred for the investigation of persistent anemia.

Materials and Methods
Following the HPLC analyses of Hb migration pattern, direct nucleotide sequencing of α- and β-globin genes was performed for all cases.

Results
The common finding was the homozygosity for the intronic change, IVSII-74 T > G.

Conclusion
In the intersection point of the variations on our patients, we claim a homozygous change at position 74 on the intron II of the β-globin gene alone may be sufficient to cause a β-thalassemia carrier phenotype.
Integrating Molecular Markers and Environmental Covariates To Interpret Genotype by Environment Interaction in Rice (Oryza sativaL.) Grown in Subtropical Areas
Authors: Monteverde Eliana , Gutierrez Lucía , Blanco Pedro , Pérez de Vida Fernando , Rosas Juan E , Bonnecarrère Victoria , Quero Gastón , McCouch Susan 
Published: March 2019

AbstractUnderstanding the genetic and environmental basis of genotype × environment interaction (G×E) is of fundamental importance in plant breeding. If we consider G×E in the context of genotype × year interactions (G×Y), predicting which lines will have stable and superior performance across years is an important challenge for breeders. A better understanding of the factors that contribute to the overall grain yield and quality of rice (Oryza sativa L.) will lay the foundation for developing new breeding and selection strategies for combining high quality, with high yield. In this study, we used molecular marker data and environmental covariates (EC) simultaneously to predict rice yield, milling quality traits and plant height in untested environments (years), using both reaction norm models and partial least squares (PLS), in two rice breeding populations (indica and tropical japonica). We also sought to explain G×E by differential quantitative trait loci (QTL) expression in relation to EC. Our results showed that PLS models trained with both molecular markers and EC gave better prediction accuracies than reaction norm models when predicting future years. We also detected milling quality QTL that showed a differential expression conditional on humidity and solar radiation, providing insight for the main environmental factors affecting milling quality in subtropical and temperate rice growing areas.
A tranexámsav vérvesztést és kis vérzéses szövődményeket befolyásoló hatása cementes csípőprotézis beültetése után
Authors: Gombár Csaba , Gálity Hristifor , Bácsi Miklós , Sisák Krisztián 
Published: March 2019

Abstract: Introduction: Tranexamic acid (TXA) is widely used during elective joint replacement to reduce blood loss and decrease the transfusion requirement. Aim:This study assessed the efficacy of tranexamic acid in reducing minor bleeding complications following primary cemented total hip replacement, when rivaroxaban is used as thromboprophylaxis, the complicated wound healing effect of which has been published recently. Method: Consecutive patients undergoing hip replacement were studied. Patients receiving tranexamic acid perioperatively between January 2014 and November 2014 were designated as the TXA-group. We compared these data with those of a group of patients who underwent the same procedure between February 2012 and December 2012 (control group), before the introduction of tranexamic acid. The authors investigated the effect of tranexamic acid on surgical wound bleeding and discharge, area of hematoma on the skin surface, thigh volume changes, calculated perioperative blood loss and transfusion requirement. Results: 168 patients, 81 in the TXA-group and 87 in the control group were included. The extent of postoperative thigh swelling was significantly less in the TXA-group, 270.3 mL (129.1–449.0) as compared with the control group, 539.8 mL (350.0–864.8, p<0.001). Tranexamic acid significantly reduced wound bleeding during the first 24 hours postoperatively (p<0.001). The amount of calculated blood loss was significantly less in the TXA-group (1150 mL [780–1496] versus 1579 mL [1313–2074] in the control group, p<0.001). Transfusion requirement was remarkably lower in the TXA-group than in the control group (15% versus 39%). Conclusions: Tranexamic acid reduces postoperative thigh volume, wound bleeding and area of hematoma on the skin surface when rivaroxaban is used as the anticoagulant. Further large scale studies could help establish the clinical relevance and long-term outcome of minor bleeding complications. Orv Hetil. 2019; 160(12): 456–463.
Ambientes virtuais de aprendizagem bilíngues para surdos em EAD
Authors: Pochmann de Quevedo Silvia Regina , Vanzin Tarcísio , Ribas Ulbricht Vania 
Published: March 2019

Tecnologias da Informação e Comunicação (TIC) constituem-se em ferramentas estratégicas na interação entre os indivíduos, os grupos sociais e as formas de organização de conhecimento na sociedade contemporânea. A popularização da internet apresenta o desafio de um paradigma centrado no respeito às diferenças e no desenvolvimento das potencialidades de todas as pessoas. Procurando contribuir para uma sociedade cada vez mais inclusiva, este artigo apresenta revisões sistemáticas da literatura, discute como os surdos estão colocados em nossa sociedade, seus principais problemas de aprendizagem e sua inserção no uso das TIC. Para tanto, a partir de um Ambiente Virtual de Aprendizagem (AVA) inclusivo, foram testadas diferentes narrativas para o ensino de Geometria Descritiva junto a alunos surdos e ouvintes. Posteriormente, grupos focais discutiram as experiências. Após, as discussões foram analisadas com base na Análise Crítica do Discurso, proposta por Norman Fairclough. Os resultados indicaram que os ambientes virtuais de aprendizagem bilíngues utilizados em Educação a Distância (EAD) poderão oferecer ao aluno surdo acessibilidade e compartilhamento com colegas ouvintes.
GESTIÓN DEL CONOCIMIENTO COMO ESTRATEGIA EN EL DIRECCIONAMIENTO DE LOS COSTOS
Authors: REATIGA CHARRIS Idelfonso 
Published: March 2019

La importancia del conocimiento, viene siendo unos de los sistemas integrados de mayor importancia al interior de las industrias y como esté coadyuva a encarar los desafíos que traen la competitividad, la innovación, el desarrollo tecnológico y los procesos productivos, variables que tiene relación con los costos de cualquier organización que tiene que enfrentar hoy en día. Es por ello el interés de diseñar estrategia de alcance organizacional para el desarrollo de la Adquisición, almacenamiento, transferencia y protección del conocimiento que mejore el direccionamiento de los costos. Este trabajo está orientado a analizar la gestión del conocimiento como estrategia en el direccionamiento de los costos en la industria.
Caracterización del comportamiento de la demanda de componentes sanguíneos en un hemocentro del Valle del Cauca
Authors: Arboleda Zúñiga Jairo , Salcedo Moncada Bryan , Ramírez Fernández Marilyn 
Published: March 2019

En este artículo se muestran los resultados del comportamiento de la demanda de componentes sanguíneos de personas en el banco de sangre de un centro hospitalario del Valle del Cauca; el cual permitirá, en un estudio posterior servir de base para la planeación y control de toda la cadena de suministro de sangre en toda la región del Valle del Cauca. Dentro de esta primera fase se tiene en cuenta la caracterización del comportamiento de la demanda de los glóbulos rojos, la cual será estimada a través de la recolección de datos de demanda en una entidad prestadora de servicios de salud y a través de pruebas de bondad de ajuste se identificó que la demanda no se adapta a ningún tipo de distribución de probabilidad, por lo que se acudió a la simulación discreta a través de distribuciones empíricas para elaborar los pronósticos más adecuados para cada tipo de grupo sanguíneo; concluyendo que el hemocentro debería realizar pedidos cada dos semanas de la siguiente manera: para el tipo de sangre A-: 2 unidades, A+: 43 unidades, AB-: 1 sola unidad, AB+: 2 unidades, para B-: 1 unidad, B+: 8 unidades, O- :4 unidades y finalmente para O+: 45 unidades de sangre.
Evaluación económica y financiera de las alternativas de uso de los residuos de la materia prima de una planta industrial de extracción de palma de aceite
Authors: ANAYA ALDANA ROBERTO , MOLINA CRESPO DIANA CECILIA 
Published: March 2019

En esta investigación se presenta el análisis y evaluación económica – financiera, la relación Costo vs Beneficio que tienen las plantas extractoras de palma de aceite en las alternativas de uso de los residuos de la materia prima. Los subproductos resultantes del proceso de la palma de aceite en las plantas de beneficio son considerados residuos y dejan de tener un valor o utilidad y pasan a ser un desecho. Estos desechos se pueden someter a un proceso de compostaje para convertirlos en fertilizantes orgánicos que son utilizados nuevamente en los cultivos de palma, con el fin de generar una mayor productividad, reducción en los costos de fertilización y contribución positiva al medio ambiente, o darle tratamiento mediante piscinas de oxidación.
EL TELETRABAJO: ¿una opción laboral acorde con las tendencias y exigencias del mercado o una figura con vacíos legislativos?
Authors: Rolón Nieto Fernando , Sánchez Barboza Shirley 
Published: March 2019

Nuestra Sociedad está cambiando, por lo cual es necesario redefinir muchos aspectos sociales y las relaciones laborales, no son la excepción. Diez años atrás era inconcebible que un empleado pudiese obtener sus propios certificados sin intermediario; hoy es totalmente distinto; solo en algunos casos es necesario la presencia de un tercero; pero no es lo usual, por ejemplo: realizar algún acuerdo comercial.
Una rápida revisión muestra que mediante las páginas web de las entidades financieras, el cliente puede obtener un certificado bancario, imprimir sus extractos, revisar balance de cuentas, de igual forma el Mercado laboral ofrece diversidad de trabajos que funcionan como el teletrabajo; Sin embargo, en estas opciones las reglas no son claras y hay algunas ambigüedades, es por ello que es de suma importancia que todos conozcamos del tema. Con este artículo pretendemos proporcionar a los lectores información con respecto a la reglamentación, información legal, artículos académicos y funcionamiento del teletrabajo en países suramericanos, con el fin de que se entienda cómo funciona el teletrabajo para lograr su correcta implementación en Colombia y se disminuya la tasa de desempleo, generando nuevas ofertas de trabajo para todo tipo de persona
SUCESIÓN DE LA EMPRESAS FAMILIARES
Authors: Granados Uribe Lina María , Ramírez Soto Gloria Inés , Gil Giraldo Alejandra 
Published: March 2019

Colombia es un país en el cual su economía se basa principalmente en un modelo de empresa familiar sin embargo solo alrededor del 30% logra pasar a una segunda generación familiar lo cual demuestra una fragilidad en la continuidad del negocio, la permanencia y sostenibilidad del mismo en el tiempo.
Con este artículo se quieren tomar los principales valores de las empresas familiares entender la dinámica de su funcionamiento, productividad y los principales factores de éxito que pueden mitigar las amenazas que traen los cambios del relevo generacional.
İspenç Tavuğu ve Horozlarında Bazı Morfolojik Özellikler
Authors: Özdemir Demir 
Published: March 2019

Bu araştırma, uzun yıllardır ülkemiz şartlarına başarı
ile uyum sağlamış İspenç genotipine ait
horoz ve tavuklarda bazı
morfolojik standartları belirlemek amacıyla yapılmıştır. Araştırmada İspenç
genotipine ait 105 horoz ve 146 tavukta 27 farklı morfolojik parametre
incelenmiş ve örneklemeler Ankara, İzmir ve Antalya illerinde yetiştirilen
farklı yaş dönemlerindeki farklı İspenç popülasyonlarında yapılmıştır.
Araştırma bulgularına göre İspenç genotipinde vücut deri rengi beyaz olarak
saptanmış ve tüm hayvanlarda yanak ve sakal tüyleri gözlenmiştir. İspenç
genotipinin her iki cinsiyetinde de ayak bileklerinde paça tüyleri saptanmış ve
her ayakta 5 adet parmak oluşumu gözlenmiştir. İspenç horoz ve tavuklarında
ortalama canlı ağırlık sırasıyla 0.733 ve 0.582 kg, vücut uzunluğu 41.85 ve
35.59 cm, açık kanat uzunluğu 50.04 ve 54.46, sırt uzunluğu 11.58 ve 10.98 cm,
göğüs genişliği 61.42 ve 55.32 mm ve boyun uzunluğu 71.71 ve 69.17 mm olarak
saptanmıştır. Horozlarda yaş dönemi ile birlikte kafatası uzunluğu
(P&lt;0.05), kafatası genişliği (P&lt;0.05), ibik uzunluğu (P&lt;0.001), ibik
genişliği (P&lt;0.001) ve oküler genişlik (P&lt;0.05) değerleri önemli düzeyde
artarken, tavuklarda yaş dönemi ile birlikte kafatası uzunluğu (P&lt;0.05),
ibik uzunluğu (P&lt;0.001), ibik genişliği (P&lt;0.001) ve oküler uzunluk
(P&lt;0.05) değerlerindeki artış önemli bulunmuştur. Sonuç
olarak bu araştırma İspenç genotipi üzerinde yapılan ilk çalışma
niteliğindedir. Araştırma bulgularının İspenç genotipinin yerli tavuk ırkı
olarak tescil edilme sürecine katkı sağlayacağı düşünülmektedir.
Trauma healing bagi masyarakat terdampak gempa Desa Gumantar Kecamatan Kayangan Lombok Utara
Authors: Sa’i Muhammad , Acim Subhan Abdullah 
Published: March 2019

[Bahasa]: Gempa Lombok yang terjadi pada bulan Agustus 2018 menimbulkan banyak korban jiwa dan kerugian materi terutama bagi warga kabupaten Lombok Utara. Pasca gempa, sebagian dari korban yang selamat dan luka mengalami trauma sehingga terganggu kondisi mental dan psikologisnya. Kondisi ini membutuhkan penanganan sehingga dapat memulihkan kondisi mental para korban gempa. Kegiatan pengabdian ini bertujuan untuk memulihkan kondisi mental dan psikologis masyarakat Lombok pasca gempa. Kegiatan pengabdian dilakukan melalui trauma healing dengan pendekatan dakwah Islam terhadap masyarakat korban gempa. Peserta kegiatan ini adalah sebanyak 60 orang yang tinggal di Desa Gumantar, Kecamatan Kayangan, Kabupaten Lombok Utara yang terdampak gempa. Hasil kegiatan menunjukkan bahwa program trauma healing dengan pendekatan dakwah Islam mampu meningkatkan kesadaran pengamalan agama yang baik sehingga memiliki semangat untuk bangkit kembali dalam menjalani kehidupannya.
Kata Kunci: korban gempa, trauma healing, mental, psikologi
[English]: The earthquakes that hit Lombok on August 2018 caused many casualties and material losses, especially for residents of North Lombok district. After the earthquakes, some of the survivors and injuries were trauma so that their mental and psychological conditions were disturbed. This condition certainly requires treatment which can restore the mental condition of the earthquake victims. This community service program aims to restore the mental and psychological conditions of the people of Lombok after the earthquake. The program was carried out through trauma healing with an Islamic da'wa approach to earthquake victims. The participants were sixty residents of Gumantar Village, Kayangan Sub-District, North Lombok. The results of the activity showed that the trauma healing program with the Islamic da'wa approach was able to increase awareness of good religious practices so that they had the spirit to live their lives again.
Keywords: earthquake victims, trauma healing, mentality, psychology
Peningkatan kompetensi pedagogis guru berbasis keterampilan dasar mengajar di MI Nurul Karim NW Kebon Ayu Gerung Lombok Barat
Authors: Fattah Abdul 
Published: March 2019

[Bahasa]: Artikel ini memaparkan peningkatan kompetensi pedagogis guru berbasis keterampilan dasar mengajar di MI Nurul Karim NW Kebon Ayu Gerung. Madrasah ini telah berdiri sejak 30 tahun lalu, namun masih banyak menghadapi hambatan, terutama berkaitan dengan masalah kualifikasi dan kompetensi guru. Kompetensi guru MI Nurul Karim NW Kebon Ayu telah dilakukan pembinaan dan pengembangan secara fungsional, sehingga memiliki kompetensi yang tinggi, terutama dalam hal kompetensi pedagogis dasar bagi seorang guru, yang meliputi komptensi membuka dan menutup pelajaran, keterampilan bertanya, keterampilan menjelaskan, dan sebagainya. Dalam kegiatan pembekalan-pelatihan ini dimaksudkan untuk memberikan orientasi dengan tujuan memberikan wawasan dan pengetahuan bagi segenap guru MI Nurul Karim NW Kebon Ayu yang menjadi peserta sebanyak 15 orang tentang konsep-konsep upaya peningkatan kompetensi pedagogis guru berbasis keterampilan dasar mengajar yang mutakhir. Kegiatan ini dalam penerapannya menggunakan metode ceramah, diskusi maupun latihan tugas tentang berbagai penting terkait kompetensi pedagogis guru. Termasuk dalam hal ini adalah konsep hypnoteaching dalam pembelajaran sebagai bagian dari metode menjelaskan. Sedangkan pendampingan merupakan kegiatan sebagai follow up dari kegiatan pembekalan-pelatihan agar guru yang berjumlah 15 orang selaku peserta tersebut benar-benar memiliki skill terbaru yang terkait dengan kepentingan implementasi kompetensi pedagogis guru berbasis keterampilan dasar mengajar.
Kata Kunci: kompetensi pedagogis, hypnoteaching, keterampilan dasar mengajar
[English]: This article describes the improvement of teacher pedagogical competencies based on basic teaching skills at MI Nurul Karim NW Kebon Ayu Gerung. This madrasa has been established since 30 years ago, but still faces many obstacles, especially related to the problem of teachers’ competence. The competence of teachers at Nuron Karim NW in Kebon Ayu has been improved and developed through a functional way so that they have high competence, especially in pedagogical competencies which includes competence to open and close lessons, asking skills, explaining skills, and so on. The training program was intended to provide orientation by providing insights and knowledge to fifty teachers of Kebon Ayu MI Nurul Karim NW about the concepts of teacher pedagogical competency improvement based on the latest basic teaching skills. This program in its application uses lecture methods, discussions and exercises on various important tasks related to teacher pedagogical competence including the concept of hypnoteaching in learning as part of the method of explaining. While mentoring is a follow-up activity so that the participants really has the latest skills related to the importance of implementing teacher pedagogical competencies based on basic teaching skills.
Keywords: paedagogical competence, hypnoteaching, basic teaching skills