bluuebunny/crossref_metadata_2025_split huggingface dataset:
A longitudinal analysis of urological chronic pelvic pain syndrome flares in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network
Authors: Sutcliffe Siobhan , Gallop Robert , Henry Lai Hing Hung , Andriole Gerald L. , Bradley Catherine S. , Chelimsky Gisela , Chelimsky Thomas , Quentin Clemens James , Colditz Graham A. , Erickson Bradley , Griffith James W. , Kim Jayoung , Krieger John N. , Labus Jennifer , Naliboff Bruce D. , Rodriguez Larissa V. , Sutherland Suzette E. , Taple Bayley J. , Landis John Richard 
Published: April 2019

ObjectiveTo describe the frequency, intensity and duration of urological chronic pelvic pain syndrome symptom exacerbations (‘flares’), as well as risk factors for these features, in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Epidemiology and Phenotyping longitudinal study.Participants and MethodsCurrent flare status (‘urological or pelvic pain symptoms that are much worse than usual’) was ascertained at each bi‐weekly assessment. Flare characteristics, including start date, and current intensity of pelvic pain, urgency and frequency (scales of 0–10), were assessed for participants’ first three flares and at three randomly selected times when they did not report a flare. Generalized linear and mixed effects models were used to investigate flare risk factors.ResultsOf the 385 eligible participants, 24.2% reported no flares, 22.9% reported one flare, 28.3% reported 2–3 flares, and 24.6% reported ≥4 flares, up to a maximum of 18 during the 11‐month follow‐up (median incidence rate = 0.13/bi‐weekly assessment, range = 0.00–1.00). Pelvic pain (mean = 2.63‐point increase) and urological symptoms (mean = 1.72) were both significantly worse during most flares (60.6%), with considerable within‐participant variability (26.2–37.8%). Flare duration varied from 1 to 150 days (94.3% within‐participant variability). In adjusted analyses, flares were more common, symptomatic, and/or longer‐lasting in women and in those with worse non‐flare symptoms, bladder hypersensitivity, and chronic overlapping pain conditions.ConclusionIn this foundational flare study, we found that pelvic pain and urological symptom flares were common, but variable in frequency and manifestation. We also identified subgroups of participants with more frequent, symptomatic, and/or longer‐lasting flares for targeted flare management/prevention and further study.
Nonconvex/nonsmooth economic load dispatch using modified time‐varying particle swarm optimization
Authors: Parouha Raghav Prasad 
Published: April 2019

AbstractIn this paper, a modified time‐varying particle swarm optimization (MTVPSO) is proposed for solving nonconvex economic load dispatch problems. It is a variant of the traditional particle swarm optimization (PSO) algorithm. In an MTVPSO, novel acceleration coefficients for cognitive and social components are presented as linear time‐varying parameters in the velocity update equation of the PSO algorithm. In the early stages of the optimization process, it improves the global search capability of particles and directs the global optima at the end stage. Additionally, a linearly decreased inertia weight is introduced in an MTVPSO, instead of a fixed constant value, which helps improve the diversity of the population. Through this modification mechanism in PSO, the proposed algorithm has a higher probability of avoiding local optima, and it is likely to find global optima more quickly. Six complex benchmark functions have been used to validate the effectiveness of the proposed algorithm. Furthermore, to demonstrate its efficiency, feasibility, and fastness, six different cases (3‐, 6‐, 13‐, 15‐, and 40‐unit systems and one large‐scale Korean power 140‐unit system) of the economic load dispatch problem are solved by an MTVPSO. The results of the proposed algorithm have been compared with state‐of‐the‐art algorithms. It was found that the proposed MTVPSO can deliver better results in terms of solution quality, convergence characteristics, and robustness.
LncRNA TRERNA1 facilitates hepatocellular carcinoma metastasis by dimethylating H3K9 in the CDH1 promoter region via the recruitment of the EHMT2/SNAI1 complex
Authors: Song Wei , Gu Yuejun , Lu Sen , Wu Huazhang , Cheng Zhenxing , Hu Jiaojiao , Qian Yanyan , Zheng Ying , Fan Hong 
Published: April 2019

AbstractObjectivesLong non‐coding RNAs (LncRNAs) play an important role in hepatocellular carcinoma development, however, as a crucial driver of hepatocellular carcinoma (HCC) metastasis, their functions in tumour metastasis remain largely unknown.Materials and methodsThe lncRNA TRERNA1 expression levels were detected in HCC by quantitative real‐time PCR (qPCR). The function of TRERNA1 was examined by wound‐healing assays, transwell assays and tail vein injection experiments. The potential regulatory mechanisms of TRERNA1 on its target genes were explored by ChIP, RIP, IP and WB assays.ResultsElevated TRERNA1 levels promoted HCC cell migration and invasion in vitro and in vivo. TRERNA1 recruited EHMT2 to dimethylate H3K9 in the CDH1 promoter region. Furthermore, EHMT2 bound to SNAI1 to suppress CDH1 expression in HCC cells. After inhibiting TRERNA1, the expression level of CDH1 was restored and was involved in the regulation of the EHMT2/SNAI1 complex. The level of TRERNA1 was positively correlated with tumour metastasis and was negatively correlated with the expression of CDH1 in HCC tissues.ConclusionsFor the first time, the current study reveals that TRERNA1 promotes cell metastasis and the invasion of HCC via the recruitment of EHMT2 and/or the EHMT2/SNAI1 complex to suppress CDH1. These data identify a novel mechanism that regulates TRERNA1 in metastatic HCC and provides a potential targeted therapy for HCC patients.
Objectifying trustworthiness: Market formation in the transport policy field
Authors: Ek Österberg Emma 
Published: April 2019

AbstractThis paper addresses market formation in the public sector, particularly questions of how and why market arrangements for public services change, and what it means in terms of governance. The paper presents an in‐depth empirical study of a case in the Swedish transport sector, building on sociological research into market formation, particularly the work of Callon, Méadel, and Rabeharisoa on the qualification of products. Given the demand for process‐oriented research into market relations, especially in the public sector, this study empirically illustrates how and why roles, relations, and objects are maintained and transformed, and how these features are cocreated in practice. Although previous research has paid relatively little attention to product qualification, this paper demonstrates that it is useful to put this process at the center of the analysis. The present findings emphasize that how products came to be objectified, in terms of provider qualities rather than technical specifications, was the compromise that enabled various logics to be at stake simultaneously. The paper also contributes by demonstrating that NPM reforms of marketization can accommodate far‐reaching attempts by public organizations to influence the market, which is especially relevant in markets in which public‐sector organizations are dominant purchasers.
Paternal Support and Involvement in Unmarried Fragile Families: Impacts on Long‐Term Maternal Mental Health
Authors: Mallette Jacquelyn K. , Futris Ted G. , Oshri Assaf , Brown Geoffrey L. 
Published: April 2019

Fragile families are defined as those that include unmarried or romantically unstable parents who have children and are socioeconomically disadvantaged. Mothers in fragile families may experience risk factors that lead to increased depressive symptoms that inhibit their ability to bounce back after stressful events. Risk factors for poorer maternal mental health may include declines in father involvement and a lack of coparenting support. This study examined the connected nature of coparenting and father involvement over time among continuously unmarried mothers from the Fragile Families and Child Wellbeing Study. A bidirectional latent growth curve analysis demonstrated that early father involvement was associated with a more gradual decline in coparenting support over the child's first 5 years, while early coparenting support also predicted a slower decline in father involvement over time. Steeper declines in coparenting support and father involvement over time were linked with more maternal depression and lower maternal life satisfaction when their child was nine. Results demonstrate a clear need for targeted intervention with both parents in fragile families to promote involved fathering behavior and enhance coparental relationships.
Foliar water uptake in Amazonian trees: Evidence and consequences
Authors: Binks Oliver , Mencuccini Maurizio , Rowland Lucy , da Costa Antonio C. L. , de Carvalho Claudio José Reis , Bittencourt Paulo , Eller Cleiton , Teodoro Grazielle Sales , Carvalho Eduardo Jorge Maklouf , Soza Azul , Ferreira Leandro , Vasconcelos Steel Silva , Oliveira Rafael , Meir Patrick 
Published: April 2019

AbstractThe absorption of atmospheric water directly into leaves enables plants to alleviate the water stress caused by low soil moisture, hydraulic resistance in the xylem and the effect of gravity on the water column, while enabling plants to scavenge small inputs of water from leaf‐wetting events. By increasing the availability of water, and supplying it from the top of the canopy (in a direction facilitated by gravity), foliar uptake (FU) may be a significant process in determining how forests interact with climate, and could alter our interpretation of current metrics for hydraulic stress and sensitivity. FU has not been reported for lowland tropical rainforests; we test whether FU occurs in six common Amazonian tree genera in lowland Amazônia, and make a first estimation of its contribution to canopy–atmosphere water exchange. We demonstrate that FU occurs in all six genera and that dew‐derived water may therefore be used to “pay” for some morning transpiration in the dry season. Using meteorological and canopy wetness data, coupled with empirically derived estimates of leaf conductance to FU (kfu), we estimate that the contribution by FU to annual transpiration at this site has a median value of 8.2% (103 mm/year) and an interquartile range of 3.4%–15.3%, with the biggest sources of uncertainty being kfu and the proportion of time the canopy is wet. Our results indicate that FU is likely to be a common strategy and may have significant implications for the Amazon carbon budget. The process of foliar water uptake may also have a profound impact on the drought tolerance of individual Amazonian trees and tree species, and on the cycling of water and carbon, regionally and globally.
A spatiotemporal assessment of field residues of rice, maize, and wheat at provincial and county levels in China
Authors: Lin Tao , Xu Jialu , Shen Xiqiang , Jiang Hao , Zhong Renhai , Wu Sensen , Du Zhenhong , Rodriguez Luis , Ting K. C. 
Published: April 2019

AbstractChina has a huge resource potential for biomass‐based renewable energy development, but the resources of field residues are still not effectively used. Rice, maize, and wheat made up 89% of staple crop production in China in 2009. A comprehensive assessment of field residues of these three crops is necessary for the development of biomass‐based industries. This research was based on multiyear county‐level data of crop production, area and yield, as well as the crop phenology information from agrometeorological stations. Spatial and temporal analyses were conducted to quantify the spatial patterns, seasonal variations, and temporal trends of the three major field residues. The mean amount of field residue of rice, maize, and wheat was 470.8 Mt/year from 2002 to 2009. Rice residue topped the field residues at 188.5 Mt/year, followed by maize (152.6 Mt/year) and wheat (129.8 Mt/year). The resource supply of field residues varied temporally throughout the season, where peak months are May, June, September, and October. The resources of all three field residues increased from 2002 to 2009, topped by maize residues at a rate of 10.0 Mt/year. Spatially, high production counties had the fast growth rate and a strong positive spatial autocorrelation. The results showed that the intersection area of East and South Central regions has a spatially concentrated residue density and a stable supply for 5 months. The region can be considered as a suitable region for bioenergy development. A better understanding of spatial and temporal distribution of crop residues could facilitate strategic and tactical bioenergy planning.
Facilitators and barriers to co‐research by people with dementia and academic researchers: Findings from a qualitative study
Authors: Waite Jacob , Poland Fiona , Charlesworth Georgina 
Published: April 2019

AbstractBackgroundPublic and patient involvement (PPI) is now established in dementia research. Barriers and facilitators to engagement from family carers and people in early stages of dementia have been explored. However, specific barriers and facilitators to co‐research with people with dementia have not previously been investigated.ObjectiveTo discover the facilitators of, and barriers to, involving people with dementia as co‐researchers, from the perspectives of people with dementia, gatekeepers (family caregivers, ethics committee members, service providers) and researchers.DesignThematic analysis of data from individual interviews about the co‐research experience.ResultsFour themes emerged from interviews with 19 participants (five people with dementia): “getting one's head round it” (assumptions about research and dementia; different forms of language); practicalities (eg transport; accessibility of communication); “this feeling of safety” (perceptions of danger, protectiveness and opportunities for building trust); and motivations (“making a difference” and “keeping doing”).ConclusionsFindings both replicate and extend previous knowledge on PPI in dementia. Cognitive capacity of potential co‐researchers with dementia is only a part of the picture, with attitudes and expectations of researchers, gatekeepers and people with dementia also forming barriers. Researcher education, adequate resourcing, and both creativity and flexibility are needed to support recruitment of co‐researchers with dementia and to enable meaningful co‐research.
Atypical intraductal proliferation detected in prostate needle biopsy is a marker of unsampled intraductal carcinoma and other adverse pathological features: a prospective clinicopathological study of 62 cases with emphasis on pathological outcomes
Authors: Shah Rajal B , Nguyen Jane K , Przybycin Christopher G , Reynolds Jordan P , Cox Roni , Myles Jonathan , Klein Eric , McKenney Jesse K 
Published: April 2019

AimsIntraductal proliferations of the prostate with more complexity and/or cytological atypia than high‐grade prostate intra‐epithelial neoplasia (HGPIN), but falling short of intraductal carcinoma (IDC‐P), are described as ‘atypical intraductal proliferation’ (AIP). When present in needle biopsy (NBX) without IDC‐P, the clinical significance is not known.Methods and resultsSixty‐two NBX cases were diagnosed as AIP over 7 years with estimated incidence of 1%. AIP was characterised by loose cribriform architecture (90%) or non‐cribriform architecture exhibiting significant nuclear atypia that fell short of IDC‐P. Fifty patients had concomitant PCa (20% grade group (GG) 1, 48% GG2, 14% GG3, 8% GG4 and 10% GG 5), and 12 had AIP alone. Of 40 patients who were candidates for no therapy (AIP alone) or active surveillance (AIP with GG1 or GG2 PCa without cribriform pattern 4), 20 had subsequent follow‐up pathology [seven NBXs and 13 radical prostatectomy (RP)]. Of the 12 AIP only patients, six had a subsequent biopsy diagnosis of: benign prostate (two), IDC‐P with PCa (one) and PCa (three). One or more adverse pathological features at subsequent RP were present in 93% of patients with AIP and GG1 or GG2 PCa, defined as: GG ≥ 3 (15%), IDC‐P (77%), cribriform Gleason pattern 4 (69%), pT3a (77%) or pT3b (8%).ConclusionsAIP in NBX may be a marker of unsampled IDC‐P and/or other adverse pathological features in suspected low‐ to intermediate‐risk PCa. AIP should be considered distinct from HGPIN for risk assessment and warrant consideration for further work‐up to detect unsampled high‐risk PCa.
Osteoarthritis‐alleviating effects in papain‐induced model rats of chicken cartilage hydrolysate and its peptide fractions
Authors: Yang Jingyi , Sun‐Waterhouse Dongxiao , Xiao Yu , He Weiwei , Zhao Mouming , Su Guowan 
Published: April 2019

SummaryThis study aims to discover natural bioactive substances as alternative therapies to current medical and surgical treatments for osteoarthritis (OA). Chicken cartilage hydrolysate (CCH) was produced using trypsin and separated via ultrafiltration into CCH‐I (molecular weight (MW) > 10 kDa) and CCH‐II (MW <10 kDa). Results showed that CCH and its fractions (CCH‐I and CCH‐II) could relieve OA with different extents, and the outcome using these treatments depended on their especial composition. CCH‐II (a fraction rich in low MW peptides with no chondroitin sulphate (CS) and low in sugar) exhibited desired OA‐alleviating effect in papain‐induced rat and highest in vitro antioxidant activities. CCH‐I (a fraction rich in CS and in high MW peptides) might have an adverse effect on renal function. Therefore, it is industrially feasible to produce anti‐inflammatory and antioxidative CCH, especially CCH‐II, with the therapeutic potential for alleviating or treating OA. Further separation of CS from CCH‐I may lead to a commercial pure CS product for treating OA.
Eating behaviour and oxytocin in patients with childhood‐onset craniopharyngioma and different grades of hypothalamic involvement
Authors: Daubenbüchel Anna M. , Özyurt Jale , Boekhoff Svenja , Warmuth‐Metz Monika , Eveslage Maria , Müller Hermann L. 
Published: April 2019

SummaryBackgroundPatients with childhood‐onset craniopharyngioma (CP) often suffer from tumour or treatment‐related hypothalamic lesions (HL). These lesions may alter production of oxytocin, which plays a major role in the regulation of eating behaviour and body composition.ObjectiveIn CP with different degrees of HL, we investigated associations between HL, eating behaviour/eating attitudes, and oxytocin saliva concentrations (OSC).MethodsIn a cross‐sectional case‐control study on 34 CP and 73 healthy controls, OSC were measured before, and 60 minutes after breakfast by immunoassay. Eating behaviour, attitudes, and habits were assessed by standardized questionnaires.ResultsCP with anterior + posterior HL presented with more adverse eating behaviours/symptoms of eating disorders than CP without HL, CP with anterior HL, and controls. Eating behaviour in CP with anterior HL was similar to controls, except for their tendency towards high dietary restraints. Decreases in postprandial compared with fasting OSC were associated with adverse eating behaviour in CP and controls and with higher BMI in CP.ConclusionsCP with anterior HL and CP with anterior + posterior HL present with distinct patterns of eating behaviour. Reduced postprandial compared with fasting OSC is associated with weight problems in CP and with adverse eating behaviour and symptoms of eating disorders in both CP and controls.
Inventor Chief Executive Officers and Firm Innovation
Authors: Bostan Ibrahim , Mian G. Mujtaba 
Published: April 2019

ABSTRACTUsing a novel, manually collected dataset, we find that firms whose chief executive officer (CEO) is an inventor experience significantly better innovation outcomes, as measured by patents and future citations. We obtain these results in models with firm fixed effects, in difference‐in‐difference analysis of transitioning CEOs that controls for the CEO fixed effects, and among firms with founder CEOs. Firms led by an inventor CEO also exhibit greater tolerance for failure as indicated by a greater number of both highly cited and uncited patents, and engage more in explorative search strategies that exploit new technological trajectories. Stock market, however, seems unable to fully capture the positive impact of inventor CEOs on future innovation: firms whose CEO transitions to be an inventor experience positive abnormal stock returns, especially during the early years following the transition.
Essential global health competencies for baccalaureate nursing students in the United States: A mixed methods Delphi study
Authors: Torres‐Alzate Herica M. , Wilson Lynda Law , Harper Doreen C. , Ivankova Nataliya V. , Heaton Karen , Shirey Maria R. 
Published: April 2019

AbstractAimsTo reach consensus among experts on global health competencies for baccalaureate nursing students in the USA.DesignA three‐round modified Delphi study using a mixed methods research approach.MethodsIn the first round, the original list of competencies (Wilson et al., 2012, Journal of Professional Nursing, 28, 213–222) was revised based on prior research, a review of literature and the Nursing Global Health Competencies Framework developed by the fist author. Nine global health domains and 52 competencies were identified in Round One. In Round Two, two surveys were conducted for validation of the revised list of global health competencies using a group of six nurses with expertise in global health and baccalaureate nursing education, which produced modifications in the competencies used for the third phase of the study. In Round Three, 41 participants completed a survey to rate the extent to which they thought the competencies obtained in Round Two were essential for baccalaureate nursing education in the United States. Data collection took place from May 2017 ‐ January 2018.ResultsA group of experts in global health and baccalaureate nursing education from the United States achieved consensus that 40 global health competencies were essential for baccalaureate nursing education in the United States.Conclusion and ImpactThe domains and competencies derived in this study can be used to guide undergraduate nursing curriculum development in global health and provide a framework for both clinical instruction and evaluation of global health student experiences.