bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of traditional and non-traditional career theories to understand the young’s relationship with new technologies
Authors: Veloso Elza Fátima Rosa , Trevisan Leonardo Nelmi , da Silva Rodrigo Cunha , Dutra Joel Souza 
Published: September 2018

PurposeThe purpose of this paper is to, which involved 123 students in their last year of an administration course at a private university in the city of São Paulo, Brazil, evaluate the importance of analyzing the pressure from new technologies on the careers of young university students from a career theory perspective.Design/methodology/approachFrom the perspective of traditional theories, the authors used “career anchors,” and from the perspective of non-traditional theories, “intelligent careers,” in which people develop three competency groups that are transferable between organizations: knowing why; knowing how; and knowing whom. The hypotheses the authors raised were analyzed using statistical techniques and the following results were obtained: young people do not see new technologies as a threat to their current job; people who see the “Knowing How” competence as being more developed feel less pressure from new technologies; non-traditional theories show a greater potential to analyze technological pressure than traditional theories; and, finally, the nature of people’s jobs produces different impacts on the pressure of new technologies on their careers, since people who occupy positions involving more human interaction with internal or external clients feel less threatened.FindingsIt was found that the lowest mean among the constructs analyzed was the pressure from technology on career. The correlations between the competencies of intelligent careers and the perception of the pressure from technology on career were weak, but significant, whereas the “Knowing How” competency was negatively correlated with the pressure caused by technology. There was no significant influence of the anchors on the pressure from technology on career. However, incorporating the competencies of intelligent careers improved the statistical model’s fit. In associating job positions with the pressure from technology on career, administrative and operational positions showed higher averages than sales associate and management positions.Originality/valueBroadly speaking, it can be noted that traditional career theories, especially the vocational counseling approach, are not sufficient to explain the impact of new technologies on careers. At the same time, one way of coping with the pressure brought about by technological advances may be in using technology itself to develop “useful professional skills,” in a manner consistent with “intelligent careers.”
Ten Agile axioms that make conventional managers anxious
Authors: Denning Stephen 
Published: September 2018

Purpose
While the principles of Agile management are simple, the implementation of the actual “Laws of Agile” is daunting to managers trained in the traditions and culture of hierarchical management. This article offers a context for the three laws.

Design/methodology/approach
Implementing Agile requires fostering a mindset that is fundamentally different from traditional preoccupations with profit maximization and hierarchical authority.

Findings
Agile is about generating instant, intimate, frictionless, low-risk, incremental value at scale. That’s the new performance requirement.

Practical implications
A growing number of companies, including those that have embraced the Agile mindset, believe the true purpose of a firm is to create customers and establish a sustainable relationship with them.

Originality/value
For leaders and managers this article offers radical insights. In an Agile organization, talent discovers strategic opportunities. Talent drives strategy. When the whole organization truly embraces Agile, instead of a steady state machine, the organization becomes an organic living network of high-performance teams. 10;
Highly stretchable, rapid-response strain sensor based on SWCNTs/CB nanocomposites coated on rubber/latex polymer for human motion tracking
Authors: Huang Ying , Hao Chao , Liu Jian , Guo Xiaohui , Zhang Yangyang , Liu Ping , Liu Caixia , Zhang Yugang , Yang Xiaoming 
Published: September 2018

Purpose
The purpose of this study is to present a highly stretchable and flexible strain sensor with simple and low cost of fabrication process and excellent dynamic characteristics, which make it suitable for human motion monitoring under large strain and high frequency.

Design/methodology/approach
The strain sensor was fabricated using the rubber/latex polymer as elastic carrier and single-walled carbon nanotubes (SWCNTs)/carbon black (CB) as a synergistic conductive network. The rubber/latex polymer was pre-treated in naphtha and then soaked in SWCNTs/CB/silicon rubber composite solution. The strain sensing and other performance of the sensor were measured and human motion tracking applications were tried.

Findings
These strain sensors based on aforementioned materials display high stretchability (500 per cent), excellent flexibility, fast response (approximately 45 ms), low creep (3.1 per cent at 100 per cent strain), temperature and humidity independence, superior stability and reproducibility during approximately 5,000 stretch/release cycles. Furthermore, the authors used these composites as human motion sensors, effectively monitoring joint motion, indicating that the stretchable strain sensor based on the rubber/latex polymer and the synergetic effects of mixed SWCNTs and CB could have promising applications in flexible and wearable devices for human motion tracking.

Originality/value
This paper presents a low-cost and a new type of strain sensor with excellent performance that can open up new fields of applications in flexible, stretchable and wearable electronics, especially in human motion tracking applications where very large strain should be accommodated by the strain sensor.
Antimicrobial and antidiabetic potential of synbiotic fermented milk: A functional dairy product
Authors: Shafi Afshan , Naeem Raja Haider , Farooq Umar , Akram Kashif , Hayat Zafar , Naz Ambreen , Nadeem Hafiz Rehan 
Published: September 2018

The current study was based on evaluation of the therapeutic potential (antimicrobial and antidiabetic) of a synbiotic fermented milk product developed by optimising levels of the prebiotic ingredients (fructooligosaccharide and isomaltooligosaccharide). The maximum growth rate (0.27 ± 0.21a cfu/mL) of Lactobacillus acidophilus ATCC® 4357™ was observed with 2.345–2.445% of fructooligosaccharide and 2.53–2.62% of isomaltooligosaccharide. Significant antimicrobial potential of the synbiotic fermented milk was observed against Escherichia coli and Staphylococcus aureus due to the addition of prebiotics. Similarly, the final product also showed 62.9%, 71.5% and 57.0% reduction in blood glucose, urea and creatinine levels, respectively, of diabetic rabbits, when supplemented with 6% of the synbiotic fermented milk. A synbiotic fermented milk product with significant therapeutic potential could be developed using fructooligosaccharide and isomaltooligosaccharide as prebiotic ingredients.
Novel frameshift mutation in the insulin (INS) gene in a family with maturity onset diabetes of the young (MODY)
Authors: Xiao Xiaoyu , Liu Lili , Xiao Yang , Xie Zhiguo , Li Long , Zhou Houde , Tang Weili , Liu Shiping , Zhou Zhiguang 
Published: September 2018

Highlights

This study reports a novel frameshift mutation c.212dupG (p.Gly73fs) in the insulin (INS) gene causing maturity onset diabetes of the young (MODY) 10, one of the rare types of MODY, identified in seven family members.
Screening for mutations in identified MODY genes is warranted in patients who require insulin, are negative for autoantibodies but have a family history of diabetes.
Mineralogy and Geochemistry of Major, Trace and Rare Earth Elements in Sediments of the Hypersaline Urmia Salt Lake, Iran
Authors: ALIPOUR Samad , MOSAVI ONLAGHI Khadije 
Published: September 2018

AbstractUrmia Salt Lake (USL) is a hypersaline lake located at the NW corner of the Iran platform. The lake area is estimated to have been over 5000 km2 at one point, but has now decreased to <1000 km2 in the last two decades. It contains 4.6×109 tons of halite and other detrital and evaporative minerals such as calcite, aragonite, dolomite, quartz, feldspars, augite and sylvite. This study examined the mineralogy and geochemistry of bed sediments along the mid‐east toward NE bank sediments collected from 1.5 meters depth and nearby augite placer. Due to the diverse lithology of the surrounding geology, bed sediments vary from felsic in the mid‐east to mafic in the northeast. Weathering of tephrite and adakite rocks of the Islamic Island at the immediate boundary has produced a large volume of augite placer over a 40 km length, parallel to the shoreline. Based on the study result, weathering increases from south to north and the geochemistry of the sediments shows enrichment of MgO, CaO, Sr and Ba associated with Sr deployment in all samples. Rare earth elements (REE) patterns normalized to the upper continental crust (UCC) indicated LREEs enrichment compared to HREEs with an elevated anomaly of Eu, possibly due to surface absorbance of Mn and Fe minerals, associated with Sr elevation originating from adakites in the lake basin vicinity.
Integrated Rock Typing of the Grainstone Facies in a Sequence Framework: a Case from the Jurassic Arab Formation in the Persian Gulf
Authors: ASSADI Ali , RAHIMPOUR‐BONAB Hossain , KADKHODAIE‐ILKHCHI Rahim 
Published: September 2018

AbstractThe late Jurassic Arab Formation, a significant carbonate‐evaporite reservoir rock in the Persian Gulf, is characterized by frequent grainstone facies. For rock type identification and reservoir characterization, core description, petrographic studies and pore system evaluation are integrated for Balal oil field in the Persian Gulf. The grainstone facies are developed into three shoal subenvironments on a carbonate ramp platform: leeward, central and seaward. Compaction, dissolution, cementation, anhydrite mineralization and dolomitization are the main diagenetic processes affecting the depositional pore system. Considering depositional and diagenetic features and pore types, the grainstones are classified into six rock types (RT 1 to RT6). Rock types 1, 2 and 5 have large pore throat sizes with intergranular and touching vug pore types. In rock type 3, moldic pores lead to high porosity and low permeability. Rock types 4 and 6 are cemented by anhydrite, calcite and dolomite. Generally, RTs 1, 2, 3 and 5 are related to late Transgressive systems tract (TST) and early Highstand systems tracts (HST) and show fair to good reservoir quality. In contrast, RTs 4 and 6 of late HST system tract show lower poroperm values, due to evaporite mineralization. Characterization of the grainstone facies provides a comprehensive understanding of the reservoir zones of the Arab Formation.
Diagenetic and Depositional Impacts on the Reservoir Quality of the Upper Jurassic Arab Formation in the Balal Oilfield, Offshore Iran
Authors: EBRAHIM Sfidari , ABDOLHOSSIEN Amini , ALI Kadkhodaie , MOHSEN Sayedali , SEYED MOHAMMAD Zamanzadeh 
Published: September 2018

AbstractThe Kimmeridgian‐Tithonian aged Arab Formation, as the main reservoir of the Jurassic succession in the Balal oilfield, located in the offshore region of the Iranian sector of the Persian Gulf, is investigated in this study. The formation is composed of dolomites and limestones with anhydrite interbeds. Based on detailed petrographic studies, six microfacies are recognized, which are classified in four sub‐environments including supratidal, intertidal, lagoonal and the high energy shoal of a homoclinal carbonate ramp. The main diagenetic features of the studied succession include dolomitization, anhydritization, cementation, micritization, fracturing and compaction. Based on stable isotope data, dolomitization of the upper Arab carbonates is related to sabkha settings (i.e. evaporative type). In terms of sequence stratigraphy, three shallowing‐upward sequences are recognized, based on core and wireline log data from four wells of the studied field. Considering depositional and diagenetic effects on the reservoir quality, the studied facies are classified into eight reservoir rock types (RRT) with distinct reservoir qualities. Dolomitization has played a major role in reservoir quality enhancement, whereas anhydritization, carbonate cementation, and compaction have damaged the pore throat network. Distribution of the recognized RRTs in time and space are discussed within the context of a sequence stratigraphic framework.
Fluid Inclusions in Surface‐temperature Halite: Sample Preparation and Application
Authors: WANG Mingquan , ZHAO Yanjun , LI Wenxia , LIU Chenglin 
Published: September 2018

AbstractPaleo‐temperature and paleo‐environment can be interpreted from measuring homogenization temperatures of fluid inclusions within halite. In order to conduct such measurements, vapor bubbles within low‐temperature fluid inclusion often need to be created through cooling process by using cooling stage or freezer. Proper cooling is critical for interpreting measured temperature data. We tested two common cooling methods, using heating/freezing stage and freezer, for studying fluid inclusions in halite precipitated in laboratory at conrtolled temperature of 25°C. While using the heating/freezing stage, halite samples were kept at –18°C for 40–50 min; whereas for freezer, samples were stored at –18°C for 1, 10, 20 and 40 days, respectively. By comparing the homogenization temperatures of the two cooling processes, we explored the detailed experimental processes and developed an optimal cooling nucleation procedure for homogenization temperature analyses of fluid inclusions within surface‐temperature halite. The results show that the maximum homogenization temperatures from both methods approximate the actual brine temperature of 25°C. However, extended refrigeration time has noticeable influence on the results. The refrigeration time of the experiment can be shortened to meet requirements.
New drug candidates for depression – a nationwide population‐based study
Authors: Kessing L.V. , Rytgaard H. C. , Gerds T. A. , Berk M. , Ekstrøm C. T. , Andersen P. K. 
Published: September 2018

ObjectiveTo investigate whether continued use of non‐aspirin NSAID, low‐dose aspirin, high‐dose aspirin, statins, allopurinol and angiotensin agents decreases the rate of incident depression using Danish nationwide population‐based registers.MethodsAll persons in Denmark who purchased the exposure medications of interest between 1995 and 2015 and a random sample of 30% of the Danish population was included in the study. Two different outcome measures were included, (i) a diagnosis of depressive disorder at a psychiatric hospital as in‐patient or out‐patient and (ii) a combined measure of a diagnosis of depression or use of antidepressants.ResultsA total of 1 576 253 subjects were exposed to one of the six drugs of interest during the exposure period from 2005 to 2015. Continued use of low‐dose aspirin, statins, allopurinol and angiotensin agents was associated with a decreased rate of incident depression according to both outcome measures. Continued uses of non‐aspirin NSAIDs as well as high‐dose aspirin were associated with an increased rate of incident depression.ConclusionThe findings support the potential of agents acting on inflammation and the stress response system in depression as well as the potential of population‐based registers to systematically identify drugs with repurposing potential.
Real‐world benefits of allergen immunotherapy for birch pollen‐associated allergic rhinitis and asthma
Authors: Wahn Ulrich , Bachert Claus , Heinrich Joachim , Richter Hartmut , Zielen Stefan 
Published: September 2018

AbstractBackgroundReal‐world evidence is sparse on the benefits of allergen immunotherapy [AIT; subcutaneous/sublingual immunotherapy (SCIT/SLIT)], the only disease‐modifying intervention for allergic rhinitis (AR) with long‐term efficacy. This real‐life study evaluated the effect of six AITs (native pollen SLIT/SCIT, four allergoid SCITs) vs symptomatic medication use, on AR symptoms and asthma symptoms/onset, in patients with birch pollen‐associated AR and/or asthma.MethodsIn this retrospective cohort analysis of a German longitudinal prescription database, AIT patients received ≥2 successive seasonal treatment cycles; non‐AIT patients had ≥3 AR prescriptions in three seasons or previous month. Patients were matched for: index year, age, gender, main indication at index, number of seasonal cycles within treatment period, baseline AR/asthma treatment prescriptions. Multiple regression analysis compared prescription data in AIT and non‐AIT groups as proxy for clinical status/disease progression.ResultsUp to 6 years of follow‐up, significantly more AIT (65.4%) vs non‐AIT (47.4%) patients were AR medication‐free; odds ratio (OR) [95% confidence interval (CI)]: 0.51 [(0.48‐0.54); P < 0.001] (28.6% covariate‐adjusted reduction vs non‐AIT; P < 0.001), and significantly more AIT (49.1%) vs non‐AIT (35.1%) patients were asthma medication‐free [OR (95% CI): 0.59 (0.55‐0.65); P < 0.001] (32% reduction vs non‐AIT; P < 0.001), or reduced existing asthma medication use (32% covariate‐adjusted reduction vs non‐AIT; P < 0.001). During treatment, new‐onset asthma risk was significantly reduced in the AIT vs non‐AIT group (OR: 0.83; P = 0.001).ConclusionsBirch pollen AIT demonstrated real‐world benefits up to 6 years post‐treatment cessation through significantly reduced AR and asthma medication intake, and significantly decreased risk of new‐onset asthma medication use on‐treatment.
Illegitimate authorship and flawed procedures: Fundamental, formal criticisms of the Declaration of Helsinki
Authors: Ehni Hans‐Joerg , Wiesing Urban 
Published: September 2018

AbstractSome of the recent criticisms published during and after the last revision process of the Declaration of Helsinki are directed at its basic legitimacy. In this article we want to have a closer look at the two criticisms we consider to be the most fundamental. The first criticism questions the legitimate authorship of the World Medical Association to publish a document such as the Declaration. The second fundamental criticism we want to examine argues that the last revision process failed to meet the standards for fair, democratic procedures. Although both criticisms deny the formal legitimacy of the Declaration in the most fundamental way, they have never been addressed in detail in a single article. We refute most of the related arguments. However, acknowledging some of the points made, improvements for future revision processes and versions of the Declaration of Helsinki are outlined.
In vitro gametogenesis and reproductive cloning: Can we allow one while banning the other?
Authors: Segers Seppe , Pennings Guido , Dondorp Wybo , de Wert Guido , Mertes Heidi 
Published: September 2018

AbstractIn vitro gametogenesis (IVG) is believed to be the next big breakthrough in reproductive medicine. The prima facie acceptance of this possible future technology is notable when compared to the general prohibition on human reproductive cloning. After all, if safety is the main reason for not allowing reproductive cloning, one might expect a similar conclusion for the reproductive application of IVG, since both technologies hold considerable and comparable risks. However, safety concerns may be overcome, and are presumably not the sole reason why cloning is being condemned. We therefore assess the non‐safety arguments against reproductive cloning, yet most of these can also be held against IVG. The few arguments that cannot be used against IVG are defective. We conclude from this that it will be hard to defend a ban on reproductive cloning while accepting the reproductive use of IVG.
An open‐label phase 2 trial of entospletinib in indolent non‐Hodgkin lymphoma and mantle cell lymphoma
Authors: Andorsky David J. , Kolibaba Kathryn S. , Assouline Sarit , Forero‐Torres Andres , Jones Vicky , Klein Leonard M. , Patel‐Donnelly Dipti , Smith Mitchell , Ye Wei , Shi Wen , Yasenchak Christopher A. , Sharman Jeff P. 
Published: September 2018

SummarySpleen tyrosine kinase (Syk) mediates B‐cell receptor signalling in normal and malignant B cells. Entospletinib is an oral, selective Syk inhibitor. Entospletinib monotherapy was evaluated in a multicentre, phase 2 study of patients with relapsed or refractory indolent non‐Hodgkin lymphoma or mantle cell lymphoma (MCL). Subjects received 800 mg entospletinib twice daily. Forty‐one follicular lymphoma (FL), 17 lymphoplasmacytoid lymphoma/Waldenström macroglobulinaemia (LPL/WM), 17 marginal zone lymphoma (MZL) and 39 MCL patients were evaluated. The primary endpoint was a progression‐free survival (PFS) rate (defined as not experiencing progression or death) at 16 weeks for patients with MCL and at 24 weeks for patients with FL, LPL/WM and MZL. The most common treatment‐emergent adverse events were fatigue, nausea, diarrhoea, vomiting, headache and cough. Common laboratory abnormalities were anaemia, neutropenia and thrombocytopenia; aspartate transaminase, alanine transaminase, total bilirubin and serum creatinine were all increased. PFS at 16 weeks in the MCL cohort was 63·9% [95% confidence interval (CI) 45–77·8%]; PFS at 24 weeks in the FL, LPL/WM, MCL and MZL cohorts was 51·5% (95% CI 32·8–67·4%), 69·8% (95% CI 31·8–89·4%), 56·6% (95% CI 37·5–71·8%) and 46·2% (95% CI 18·5–70·2%), respectively. Entospletinib had limited single‐agent activity with manageable toxicity in these patient populations.
“I'm Kind of a Feminist”: Using Master Narratives to Analyze Gender Identity in Middle Childhood
Authors: Rogers Leoandra Onnie 
Published: September 2018

A robust literature documents the significance of gender in children's development, but gaps remain in understanding how developing gender identities link to gender inequalities. This article uses master narratives to analyze the ways that children's gender narratives reinforce or disrupt gender inequality. Semistructured interviews were conducted with 233 Black, White, mixed‐ and other‐race minority children (7–12 years old; Mage = 9.92; 61% girls) in racially diverse schools in the Pacific Northwest. Four narrative types were identified: two “master narratives” that reinforced gender inequality and two “alternative narratives” that disrupted it. Analyses revealed that 5th/6th‐graders (vs. 2nd–4th graders) and girls (vs. boys) were more likely to tell alternative narratives. The contributions of master narratives for understanding gender identity, development, and inequality are discussed.
LncRNA B4GALT1‐AS1 recruits HuR to promote osteosarcoma cells stemness and migration via enhancing YAP transcriptional activity
Authors: Li Zhikun , Wang Yi , Hu Ruixi , Xu Ruijun , Xu Wei 
Published: September 2018

AbstractObjectivesThis study aims to reveal the roles and related mechanisms of LncRNA B4GALT1‐AS1 in osteosarcoma (OS) cells stemness and migration.Materials and methodsReal‐time quantitative PCR (RT‐qPCR) was used to detect the expression of several LncRNAs in OS tissues and normal adjacent tissues and in OS mammospheres and cells. Cell viability, transwell migration, tumour spheres formation and in vivo tumour formation assays were used to examine the effects of LncRNA B4GALT1‐AS1 on OS progression. In addition, RNA immunoprecipitation (RIP) and Luciferase reporter assays were performed to determine the binding site of RNA‐binding protein HuR on B4GALT1‐AS1 and transcriptional factor YAP. Immunofluorescence analysis was used to examine YAP nuclear‐cytoplasm translocation.ResultsLncRNA B4GALT1‐AS1 expression was significantly increased in OS tissues and cells spheres. Knockdown of B4GALT1‐AS1 inhibited OS cells proliferation, migration, stemness and chemotherapeutic sensitivity. Mechanistically, B4GALT1‐AS1 recruited HuR to enhance YAP mRNA stability and thus its transcriptional activity.ConclusionsWe indicate that lncRNA B4GALT1‐AS1 promotes OS cells stemness and migration via recruiting HuR to enhance YAP activity.