bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Jintiange Capsules in the Treatment of Osteoporosis: A Network Meta‐analysis
Authors: Sun Jing , Yang Xiong‐gang , Hu Yong‐cheng 
Published: March 2019

ObjectiveTo evaluate the efficacy of Jintiange capsules and Jintiange combined with other therapies in the treatment of osteoporosis.MethodsA systematic review of the literature was conducted through databases including China National Knowledge Infrastructure (CNKI), the VIP Database for Chinese Technical Periodicals (VIP), Wanfang, and PubMed from inception to April 2018. Network meta‐analysis was used to determine the relative efficacy of related treatments on osteoporosis. The primary outcome measures are the bone mineral density (BMD) of the lumbar and femoral neck, and the secondary outcome measures are visual analog pain score (VAS) and adverse events. Two reviewers independently selected the studies, extracted information, and assessed the quality of included trials. Data extracted from eligible studies was pooled and meta‐analyzed, and the mean differences (MD) with their 95% confidence intervals were estimated as the effect size between treatments.ResultsThirty‐one studies were included in this study, containing 28 randomized controlled trials (RCT) and 3 non‐randomized controlled trials (non‐RCT), with a total of 14 regimens treating osteoporosis. According to the surface under the cumulative ranking (SUCRA) curves, Jintiange capsules combined with atorvastatin (89.9%) and Jintiange combined with bisphosphonates (88.2%) have the best efficacy in terms of the BMD of the lumbar and femoral neck, respectively. Based on the VAS, Jintiange combined with calcium has the best analgesic effect (83.4%).ConclusionJintiange capsules alone and combined with other therapies is a good choice for treating patients with osteoporosis in terms of improving BMD, relieving pain, and reducing adverse events. More large‐scale and well‐designed RCT are warranted to confirm the results of this study.
Perioperative anaphylaxis in a patient with a solitary mastocytoma
Authors: Requena López Sheila , Matito Almudena , Alvarez‐Twose Iván , Torrelo Antonio 
Published: March 2019

AbstractChildren with more extensive cutaneous mastocytosis have a higher risk for symptoms secondary to release of mast cell mediators. However, the remote possibility of anaphylaxis in patients with a solitary lesion suggests the need for cautious use of general anesthesia in these children. We describe an unusual case of a patient with a solitary mastocytoma who experienced an anaphylactic reaction during a surgical procedure and make recommendations to reduce the risk of intraoperative anaphylaxis in mast cell disease.
Full‐term newborn infant with blistering skin lesions—Caution regarding use of pain medications
Authors: Hussain Aamir , Sanders Melinda , Riotte Clare , Hussain Naveed 
Published: March 2019

AbstractMultiple opioids are known to trigger mast cell degranulation. We report the case of a neonate with blistering skin lesions at birth who died of multi‐organ failure after administration of morphine. Given the excessive histamine release and potential complications associated with morphine administration, alternative opioids and adjuvants should be considered in infants presenting with evidence of bullous or infiltrative skin lesions until mastocytosis is ruled out.
Multi‐temporal transport network models for accessibility studies
Authors: Tomasiello Diego Bogado , Giannotti Mariana , Arbex Renato , Davis Clodoveu 
Published: March 2019

AbstractVehicle tracking is a spatio‐temporal source of high‐granularity travel time information that can be used for transportation planning. However, it is still a challenge to combine data from heterogeneous sources into a dynamic transport network, while allowing for network modifications over time. This article uses conceptual modeling to develop multi‐temporal transport networks in geographic information systems (GIS) for accessibility studies. The proposed multi‐temporal network enables accessibility studies with different temporal granularities and from any location inside the city, resulting in a flexible tool for transport and urban planning. The implemented network is tested in two case studies that focus on socially excluded people in a large global city, São Paulo, Brazil, including accessibility analyses from slum areas. It explores variations within a day and differences between transport modes across time. Case study results indicate how the accessibility is heterogeneous in low‐income regions.
Effects of Exercise During or Postchemotherapy in Cancer Patients: A Systematic Review and Meta‐Analysis
Authors: Zeng Jingchun , Wu Jiaming , Tang Chunzhi , Xu Nenggui , Lu Liming 
Published: March 2019

AbstractBackgroundExercise may effectively reduce side effects caused by chemotherapy. However, no meta‐analyses of exercise during or postchemotherapy for cancer patients have been definitely performed to guide clinical practice.AimsTo evaluate and summarize available scientific evidence to provide recommendations of an exercise intervention for cancer patients undergo chemotherapy.MethodsA systematic review and meta‐analysis were performed with databases searching of MEDLINE, Cochrane Library, and Embase from their inception to October 15, 2017. Literature was selected to identify randomized controlled trials of exercise during or postchemotherapy for cancer patients. Risk‐of‐bias assessment was performed by two reviewers independently. Data were analyzed using the Cochrane Collaboration's RevMan 5.3 (Review Man, Copenhagen, Denmark).ResultsA total of 10 trials with 838 participants were included in our study. Exercise could have a beneficial effect in cancer patients undergo chemotherapy in the outcome of physical fitness (MD: 0.16, 95% CI: 0.08–0.25, p < .01 and MD: 2.46, 95% CI: 1.44–3.47, p < .01) and depression (MD: −1.36, 95% CI: −2.68 to −0.04, p = .04), but not in FACT‐G, FACT‐B, anxiety, weight, and BMI (all p > .05). Exercise sequence (during or postchemotherapy) did not influence the effect of exercise for cancer patients undergo chemotherapy. In total, six studies were assessed as an overall low risk of bias. Subgroup analyses and sensitivity analyses reached results similar to those of the meta‐analyses, which reflected our results were reliable and robust.Linking Evidence to ActionExercise seems to have a beneficial effect on physical fitness and depression, but not on quality of life, anxiety, weight, and BMI. More specific and detailed description of the implementation of exercise programs should be proposed in the future.
Turn Dreams into Realities: Navigating the Transition from College to Professional Life
Authors: Ross Craig M. , Young Sarah J. 
Published: March 2019

One of the toughest transitions in most people's lives is from the schoolroom to the workplace. High school and college graduates are primed for this jolting change with lofty well-meant speeches projecting bright hopes for the future and spouting wise counsel about how to make it in the business world and what pitfalls to avoid. They are, in effect, given a healthy dose of inspiration, a hearty pat on the back and then encouraged to go out into the world and make it—on your own—because that's what it boils down to in the end. No question about it. Of course, there's no other way. Venturing out into the world is just that. But no amount of preparation, however well-intended, could achieve a smooth and easy transition from the accustomed routine of regularly scheduled classes and classwork to the hard competitive world of job seeking and … getting ahead (Dreyer, 1992, p. 17).
Effectiveness and cost-effectiveness of basic versus biofeedback-mediated intensive pelvic floor muscle training for female stress or mixed urinary incontinence: protocol for the OPAL randomised trial
Authors: Hagen Suzanne , McClurg Doreen , Bugge Carol , Hay-Smith Jean , Dean Sarah Gerard , Elders Andrew , Glazener Cathryn , Abdel-fattah Mohamed , Agur Wael Ibrahim , Booth Jo , Guerrero Karen , Norrie John , Kilonzo Mary , McPherson Gladys , McDonald Alison , Stratton Susan , Sergenson Nicole , Grant Aileen , Wilson Lyndsay 
Published: March 2019

IntroductionAccidental urine leakage is a distressing problem that affects around one in three women. The main types of urinary incontinence (UI) are stress, urgency and mixed, with stress being most common. Current UK guidelines recommend that women with UI are offered at least 3 months of pelvic floor muscle training (PFMT). There is evidence that PFMT is effective in treating UI, however it is not clear how intensively women have to exercise to give the maximum sustained improvement in symptoms, and how we enable women to achieve this. Biofeedback is an adjunct to PFMT that may help women exercise more intensively for longer, and thus may improve continence outcomes when compared with PFMT alone. A Cochrane review was inconclusive about the benefit of biofeedback, indicating the need for further evidence.Methods and analysisThis multicentre randomised controlled trial will compare the effectiveness and cost-effectiveness of PFMT versus biofeedback-mediated PFMT for women with stress UI or mixed UI. The primary outcome is UI severity at 24 months after randomisation. The primary economic outcome measure is incremental cost per quality-adjusted life-year at 24 months. Six hundred women from UK community, outpatient and primary care settings will be randomised and followed up via questionnaires, diaries and pelvic floor assessment. All participants are offered six PFMT appointments over 16 weeks. The use of clinic and home biofeedback is added to PFMT for participants in the biofeedback group. Group allocation could not be masked from participants and healthcare staff. An intention-to-treat analysis of the primary outcome will estimate the mean difference between the trial groups at 24 months using a general linear mixed model adjusting for minimisation covariates and other important prognostic covariates, including the baseline score.Ethics and disseminationApproval granted by the West of Scotland Research Ethics Committee 4 (16/LO/0990). Written informed consent will be obtained from participants by the local research team. Serious adverse events will be reported to the data monitoring and ethics committee, the ethics committee and trial centres as required. A Standard Protocol Items: Recommendations for Interventional Trials checklist and figure are available for this protocol. The results will be published in international journals and included in the relevant Cochrane review.Trial registration numberISRCTN57746448; Pre-results.
Implementing Gene Expression Programming in the Parallel Environment for Big Datasets’ Classification
Authors: Jȩdrzejowicz Joanna , Jȩdrzejowicz Piotr , Wierzbowska Izabela 
Published: March 2019

The paper investigates a Gene Expression Programming (GEP)-based ensemble classifier constructed using the stacked generalization concept. The classifier has been implemented with a view to enable parallel processing with the use of Spark and SWIM — an open source genetic programming library. The classifier has been validated in computational experiments carried out on benchmark datasets. Also, it has been inbvestigated how the results are influenced by some settings. The paper is an extension of a previous paper of the authors.
Social Factors, Sex, and Mortality Risk After Coronary Artery Bypass Grafting: A Population‐Based Cohort Study
Authors: Nielsen Susanne , Giang Kok Wai , Wallinder Andreas , Rosengren Annika , Pivodic Aldina , Jeppsson Anders , Karlsson Martin 
Published: March 2019

Background

Little is known of the impact of social factors on mortality after coronary artery bypass grafting (
CABG
). We explored sex‐ and age‐specific associations between mortality risk after
CABG
and marital status, income, and education.

Methods and Results

This population‐based register study included 110 742
CABG
patients (21.3% women) from the
SWEDEHEART
registry (Swedish Web‐system for Enhancement and Development of Evidence‐based Care in Heart Disease Evaluated According to Recommended Therapies) operated 1992 to 2015. Cox regression models were used to study the relation between social factors and all‐cause mortality. Never having been married compared with being married/cohabiting was associated with a higher risk in women than in men (hazard ratio 1.32, 95%
CI
1.20–1.44) versus 1.17 (1.13–1.22),
P
=0.030 between sex. The lowest income quintile, compared with the highest, was associated with higher risk in men than in women (hazard ratio 1.44 [1.38–1.51] versus 1.25 [1.14–1.38],
P
=0.0036). Lowest education level was associated with higher risk without sex difference (hazard ratio 1.15 [1.11–1.19] versus 1.25 [1.16–1.35],
P
=0.75). For unmarried women aged 60 years at surgery with low income and low education, mortality 10 years after surgery was 18%, compared with 11% in married women with high income and higher education level. The median life expectancy was 4.8 years shorter. Corresponding figures for 60‐year‐old men were 21% versus 12% mortality risk at 10 years and 5.0 years shorter life expectancy.

Conclusions

There are strong associations between social factors and mortality risk after
CABG
in both men and women. These results emphasize the importance of developing and implementing secondary prevention strategies for
CABG
patients with disadvantages in social factors.
Daily Practice Managing Resistant Multiple Sclerosis Spasticity With Delta-9-Tetrahydrocannabinol: Cannabidiol Oromucosal Spray: A Systematic Review of Observational Studies
Authors: Akgün Katja , Essner Ute , Seydel Cordula , Ziemssen Tjalf 
Published: March 2019

Background/purpose: Spasticity is one of the most common symptoms in people with multiple sclerosis (MS). Conventional anti-spasticity agents have limitations in their efficacy and tolerability. Delta-9-tetrahydrocannabinol: cannabidiol (THC:CBD) spray, a cannabinoid-based medicine, is approved as an add-on therapy for MS spasticity not adequately controlled by other anti-spasticity medications. The results from randomized controlled trials (RCTs) have demonstrated a reduction in the severity of spasticity and associated symptoms. However, RCTs do not always reflect real-life outcomes. We systematically reviewed the complementary evidence from non-interventional real-world studies. Methods: A systematic literature review was conducted to identify all non-RCT publications on THC:CBD spray between 2011 and 2017. Data on study design, patient characteristics, effectiveness, and safety outcomes were extracted from those publications meeting our inclusion criteria. Results: In total, we reviewed 14 real-world publications including observational studies and treatment registries. The proportion of patients reaching the threshold of minimal clinical important difference (MCID), with at least a 20% reduction of the spasticity Numeric Rating Scale (NRS) score after 4 weeks ranged from 41.9% to 82.9%. The reduction in the mean NRS spasticity score after 4 weeks was maintained over 6-12 months. The average daily dose was five to six sprays. Delta-9-tetrahydrocannabinol: cannabidiol was well tolerated in the evaluated studies in the same way as in the RCTs. No new or unexpected adverse events or safety signals were reported in everyday clinical practice. Conclusions: The data evaluated in this systematic review provide evidence for the efficacy and safety of THC:CBD in clinical practice and confirm results obtained in RCTs.
Long-term results of total knee arthroplasty in hemophilic arthropathy
Authors: Santos Silva Marta , Rodrigues-Pinto Ricardo , Rodrigues Cláudia , Morais Sara , Costa e Castro José 
Published: March 2019

Purpose: Knee arthropathy is a frequent complication affecting hemophilic patients, which can cause severe pain and disability. When conservative measures fail, total knee arthroplasty (TKA) may be performed. Methods: Eighteen TKA were performed in 15 patients with hemophilia during a 24-year period in a Hemophilia Comprehensive Care Center. All patients were evaluated by a multidisciplinary team constituted by a hematologist, an orthopedic surgeon, and a physical medicine and rehabilitation physician. Mean follow-up was 11.3 years. Results: Ten-year survival rate with prosthesis removal as end point was 94.3%. At last, follow-up visual analog pain scale score was 3.2 points, knee osteoarthritis outcome scale was 86.7 points, and mean range of motion was 88°. Only two patients required perioperative transfusion. Complication rate was 27.8% and included two infections, two prosthesis stiffness, and one case of recurrent hemarthrosis. Conclusion: After appropriate medical optimization and with prompt rehabilitation, TKA can be performed in hemophilic patients with good clinical results and survivor rates comparable to nonhemophilic patients.
Dyes and biological sources in nineteenth to twentieth century ethnographic textiles from Transylvania, Romania
Authors: Petroviciu Irina , Teodorescu Iulia , Albu Florin , Virgolici Marian , Nagoda Eugenia , Medvedovici Andrei 
Published: March 2019

Abstract
Liquid chromatography with UV–Vis and mass spectrometric detection (LC–DAD–MS) was applied to the identification of dyes and biological sources in samples from nineteenth to twentieth century ethnographic textiles from ASTRA National Museum Complex, Sibiu, Transylvania. The objects are part of the Romanian traditional costume and are among the first to be acquired for the museum collections, around 1905. Oral and written information mention such objects as homemade, with nearby materials, while literature mentions a significant number of local vegetal sources as being used for textile dyeing. The analytical protocol developed, based on the combined use of the UV–Vis and mass spectrometric detectors to associate the information and distinguish between major and minor dyes, facilitates a clear attribution of the dyes and biological source/sources used. Other techniques, such as X-ray spectroscopy and FTIR-ATR were successfully used to identify inorganic dyes, which may not be detected by LC–DAD–MS, as was the case of Prussian blue. A large number of biological sources was identified in the studied objects, both local and imported. The local sources identified include dyer’s broom (Genista tinctoria L.), sawwort (Serratula tinctoria L.), young fustic (Cotinus coggygria Scop.), Rhamnus berries, emodin based dyes (Rhamnus, Rheum, Rumex sp.) and woad (Isatis tinctoria L.), in perfect correlation with literature which states that local dyes were still in use in the period under discussion. Carminic acid containing insects (Dactylopius coccus Costa and Porphyrophora sp.) and redwood type Caesalpinia species should be considered a result of trade. Almost all the natural and synthetic dyes detected are frequently mentioned in a collection of recipes published by the Romanian Academy, in 1914. The richness in colours in belts, the use of insect dyes in shirts decoration and the large amount of cotton in shirts are illustrative for the owners’ status. The study provides a better valorisation of the Romanian traditional costume as witness of the rural society at the end of the nineteenth to beginning of the twentieth century and emphasizes the usefulness of chemistry in cultural heritage dedicated applications.
Family-inclusive practice in a psychiatric intensive care unit
Authors: Sedgwick Rosemary , Duff Alexa , Lines Sharon , Akenzua Anthony , Jones Fergal 
Published: March 2019

Aims and MethodThe National Institute for Health and Care Excellence recommends involving the families of patients admitted to psychiatric hospital care, without specific guidance on how to do it. To improve family involvement in a National Health Service psychiatric intensive care unit, a relatives' and carers' clinic was set up. Fifty family members attended and completed questionnaires. Nine went on to take part in interviews, the results of which were analysed using thematic analysis.ResultsFamilies felt more informed and found the increased access to information useful. They felt that the process showed respect for them and their family member, and that their contribution was valued. Running throughout the interviews was the contrast with previous experiences; families reported feeling heard and understood and attributed this in part to timing and environment.Clinical implicationsThe clinic was viewed positively by families and met the trust's commitment to including carers, as well as national guidance which suggests it should be part of routine practice.
Comparison of the oxidative potential of primary (POA) and secondary (SOA) organic aerosols derived from α-pinene and gasoline engine exhaust precursors
Authors: Lovett Christopher , Baasiri Mohamad , Atwi Khairallah , Sowlat Mohammad H. , Shirmohammadi Farimah , Shihadeh Alan L. , Sioutas Constantinos 
Published: March 2019

Background: Primary (POA) and secondary (SOA) organic aerosols, deriving from both anthropogenic and biogenic sources, represent a major fraction of ambient particulate matter (PM) and play an important role in the etiology of respiratory and cardiovascular diseases, largely through systemic inflammation and cellular oxidative stress. The relative contributions of these species to the inhalation burden, however, are rather poorly characterized. In this study, we measured the in vitro oxidative stress response of alveolar macrophages exposed to primary and secondary PM derived from both anthropogenic and biogenic sources. Methods: POA and SOA were generated within an oxidation flow reactor (OFR) fed by pure, aerosolized α-pinene or gasoline engine exhaust, as representative emissions of biogenic and anthropogenic sources, respectively. The OFR utilized an ultraviolet (UV) lamp to achieve an equivalent atmospheric aging process of several days. Results: Anthropogenic SOA produced the greatest oxidative response (1900 ± 255 µg-Zymosan/mg-PM), followed by biogenic (α-pinene) SOA (1321 ± 542 µg-Zymosan/mg-PM), while anthropogenic POA produced the smallest response (51.4 ± 64.3 µg-Zymosan/mg-PM). Conclusions: These findings emphasize the importance of monitoring and controlling anthropogenic emissions in the urban atmosphere, while also taking into consideration spatial and seasonal differences in SOA composition. Local concentrations of biogenic and anthropogenic species contributing to the oxidative potential of ambient PM may vary widely, depending on the given region and time of year, due to factors such as surrounding vegetation, proximity to urban areas, and hours of daylight.