bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urinary albumin strip assay as a screening test to replace quantitative technology in certain conditions
Authors: Salinas Maria , López-Garrigós Maite , Flores Emilio , Lugo Javier , Leiva-Salinas Carlos 
Published: July 2018

Abstract

Background
The clinical laboratory plays a crucial role in the diagnosis and monitoring of chronic kidney disease. The quantitative measurement of urine albumin in a spot sample, expressed as ratio per creatinine (ACR) is the most frequently used biomarker for such a purpose. Our aim was to evaluate the diagnostic performances of a strip for measuring ACR for differentiating patients who are candidates for subsequent albumin quantification, and to evaluate the economic effects of its implementation.

Methods
We systematically measured strip analysis when quantitative urinary albumin was requested. Semiquantitative urinary albumin was measured using a UC-3500 (Sysmex, Kobe, Japan), based on the protein error of a pH indicator. We collected and reviewed all the values of quantified urinary albumin and their corresponding results in ACR strip tests. We calculated the diagnostic indicators for ACR at different albumin and creatinine values using the quantitative ACR measurement as a “gold standard”. We also studied the economic effects based on both tests prices (€1.31 for quantitative albumin plus creatinine, and €0.04 for an albumin strip).

Results
The study included 9148 patients (mean age 63, 46.3% men). The results at different albumin and creatinine cutoffs showed the best performance when 10 mg/L and above 50 mg/dL, respectively. Based on our results, we would have saved 3506 urine albumin and creatinine tests in the study period, corresponding to €4226.94.

Conclusions
The present study supports the use of the ACR strip test to identify pathological albuminuria values to be measured through quantitative methods. Considerable economic savings are possible.
A new selective, and sensitive method for the determination of lixivaptan, a vasopressin 2 (V2)-receptor antagonist, in mouse plasma and its application in a pharmacokinetic study
Authors: Alrabiah Haitham , Abunassif Mohammed , Attia Sabry , Mostafa Gamal Abdel-Hafiz 
Published: July 2018

AbstractA new, selective and sensitive HPLC method for the determination of lixivaptan, an oral selective vasopressin 2 (V2)-receptor antagonist, was investigated and validated. A Waters symmetry C18 column was used as a stationary phase in isocratic elution mode using a mobile phase composed of KH2PO4(100 mM)-acetonitrile (40: 60, v/v) at a flow rate of 1.5 mL min-1. Diclofenac was used as the internal standard (IS). Lixivaptan and the IS were extracted from plasma by protein precipitation and were detected at 260 nm. Lixivaptan and diclofenac were eluted at 3.6 and 6.2 min, respectively. The developed method showed good linearity over the calibration range of 50 -1000 ng mL-1with a lower limit of detection of 16.5 ng mL-1. The extraction percentage of lixivaptan in the mouse plasma was in the range of 88.88 - 114.43%, which indicates acceptable extraction. The aforementioned method was validated according to guidelines of the International Council on Harmonization (ICH). The intra- and inter-day coefficients of variation did not exceed 5.5%. This method was presented to be simple, sensitive, and accurate and was successfully adapted in a pharmacokinetic study of the profile of lixivaptan in mouse plasma. A mean maximum plasma concentration of lixivaptan of 113.82 ng mL-1was achieved in 0.5 h after oral administration of a 10 mg kg-1dose in mouse as determined using the developed method.
Density functional theory calculations, vibration spectral analysis and molecular docking of the antimicrobial agent 6-(1,3-benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin-4-yl)ethyl] sulfanyl}pyrimidin-4(3H)-one
Authors: Almutairi Maha S. , Soumya S. , Al-Wabli Reem I. , Joe I. Hubert , Attia Mohamed I. 
Published: July 2018

AbstractVibrational spectral analysis and quantum chemical computations based on density functional theory have been performed on the antimicrobial agent 6-(1,3-benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin- 4-yl)ethyl]sulfanyl}pyrimidin-4-(3H)-one.The equilibrium structural geometry, various bonding features and harmonic vibrational wavenumbers of the title compound have been investigated using DFT-B3LYP function at 6-311++G(d, p) basis set. The detailed interpretations of the vibrational spectra have been carried out with the aid of VEDA 4 program. The various intramolecular interactions of the title compound have been exposed by natural bond orbital analysis. The FT-IR and FT-Raman spectra of the title molecule have been recorded and analyzed. Blue-shifting of the C-H wavenumber along with a decrease in the C-H bond length attribute for the formation of the C-H...O hydrogrn bonding provide an evidence for a charge transfer interaction. Also, the distribution of natural atomic charges reflects the presence of intramolecular hydrogen bonding. The analysis of the electron density of HOMO and LUMO gives an idea of the delocalization and the low value of energy gap indicates electron transfer within the molecule. Moreover, molecular docking studies revealed the possible binding of the title molecule to different antimicrobial target proteins.
Cardiac Echinococcosis Involving Left Ventricular Myocardium in an 18-Year-Old Patient
Authors: Vazhev Zaprin G. , Stoev Hristo A. 
Published: July 2018

Abstract
The hydatid disease is one of the most common tapeworm infections. It is caused most commonly by Echinococcus granulosus and has an endemic distribution. The transmission to humans, which are intermediate hosts, occurs by ingestion of contaminated food and water or by direct contact with infected animals. Involvement of heart and pericardium is an extremely rare condition.
We present a case of an 18-year-old female patient, admitted in cardiology department complaining of chest pain and subfebrility. Transthoracic echocardiography and contrast enhanced CT revealed huge well-organized intramyocardial cyst in the lateral left ventricular wall with a few daughter cysts. The diagnosis of cardiac echinococcosis was confirmed by serological blood test - ELISA. We performed total resection of the cyst using extracorporeal circulation. The postoperative period was uneventful. Albendazole treatment was administered. The patient was followed-up one year with good postoperative result without any signs of relapse of the disease.
Cardiac hydatid disease is rarity, but it is a life-threatening condition because of the high risk of cyst perforation. Early diagnosis and treatment are crucial. Echocardiographic findings are extremely valuable for diagnosis. The results of surgical echinococcectomy combined with oral antihelmintic therapy postoperatively are preferred rather than conservative strategy alone.
Obesity is Associated with Upgrading in Prostate Cancers
Authors: Sungur Mustafa , Çalışkan Selahattin 
Published: July 2018

Abstract
Background: Prostate cancer (PCa) is the second most common cancer and sixth most common cause of cancer associated death among men in the world. Multiple studies demonstrated the relationship between obesity and PCa in the recent years.
Aim: The present study aimed to investigate the impact of obesity on postoperative oncological results after radical prostatectomy.
Materials and methods: A total of 110 patients who were treated radical prostatectomy between January 2011 and April 2016 were analyzed retrospectively. The patients who had information about age, height, weight, biopsy results, PSA level and pathological results were recorded. The patients were classified to three groups according to the BMI; normal (BMI<25 kg/m2), overweight (BMI>25 and <30 kg/m2) and obese (BMI>30 kg/m2).
Results: The present study included 101 patients. Of these patients; 26, 57 and 18 patients were in groups respectively. The age at the presentation and PSA level was lower and higher than the other patients. The proportion of locally advanced disease and high grade PCa were the highest in obese patients at prostatectomy specimen examination. The upgrading is significantly associated with obesity.
Conclusion: This study demonstrated that obese men are younger and had higher PSA concentration at the diagnosis of PCa. High grade PCa, locally advanced disease and upgrading was seen much more in patients with BMI>30 kg/m2 at final pathology. The difference reached significance for upgrading between groups.
Root Development of Permanent Incisors and Mandibular Molars in Correlation with Treatment Plan
Authors: Tarpomanov Yordan , Rimalovska Sevda , Belcheva Ani , Yordanova Miroslava , Yordanova Svetla , Kukleva Maria 
Published: July 2018

Abstract
Background: The incisors and molars play a major role in the formation and function of permanent dentition. Much research has been devoted to investigating the eruption of teeth and their root development.
Aim: To study the root development of permanent incisors and mandibular molars in correlation with treatment plan and proper treatment protocols.
Materials and methods: The Demirjian’s method was used to assess the root development of incisors and mandibular molars in children between 7 and 12 years old.
Results: In 7-year-old children most of the lower first mandibular molars (76%) had complete root length, but open apices. Eighty-two percent of the roots of the first mandibular molars of the 8-year-old children and 54% of these molars of the 9-year-old children were with open apices. The first mandibular molars had incomplete roots in the 10-year-olds (6%) and even in the 11-year-old children (4%). We detected Stage E in 32% of the 10-year-olds and in 24% of the 11-year-old children. Even in 12-year-old children we found Stage E in 4% of them from their panoramic X-rays. We detected complete root development in all of the children at the age of 12.
Conclusions: Dental practitioners have to wait until the age of 10, 11 and even 12 to extract the first molars, when the furcation is formed. Proper clinical examination and diagnostic radiographs should be done before the beginning of the treatment of molars and incisors at the age between 7 and 12.
Perioperative Blood Management in Posterior Instrumented Fusion for Adolescent Idiopathic Scoliosis: Original Study and Short Review of the Literature
Authors: Katranitsa Lamprini , Gkantsinikoudis Nikolaos , Kapetanakis Stylianos , Charitoudis Georgios , Christodoulou Anastasios , Givissis Panagiotis 
Published: July 2018

Abstract
Background: The potential hazards of allogeneic blood transfusion are well established in literature. Few things are known, however, about the results of combining different blood saving techniques and their results in avoiding allogeneic blood transfusion (ABT) in scoliosis surgery.
Aim: To report specific results about utilization of preoperative autologous blood donation (PABD) and intraoperative blood-saver (BLDS) in conjunction, aiming to minimize the need for ABT.
Materials and methods: Between 1989 and 2012, 107 patients underwent posterior instrumented fusion (PIF) for adolescent idiopathic scoliosis (AIS) correction. Retrospective evaluation was conducted. Patients were classified into two groups, according to the method utilized: group A with only allogeneic blood transfusion (ABT) and group B where PABD with BLDS intraoperatively was applied. Hematocrit and hemoglobin values were evaluated preoperatively, postoperatively, and at discharge. The variables we examined included also gender, age, levels fused and number of predeposited blood units, required transfused blood units (TBU), as well as ABT rates between the two groups.
Results: More than 70% of the transfusions in both groups were needed intraoperatively. In group A, an average of 2.4 units per patient was transfused and ABT reached 76%. In contrast, in group B an average of 4.5 units per patient was transfused but ABT rate was only 7.3%, while the rest 92.7% was autologous blood. However, the wasted autologous blood reached 24.9%.
Conclusions: Our results demonstrated that PABD with intraoperative cell salvage (CS) is associated with statistically significant ABT rates decrement but the combination of these methods cannot assure ABT avoidance.
“Language” and “discourse”: Two perspectives on linguistic philosophy
Authors: Wang Yongxiang 
Published: July 2018

AbstractWith the establishment of modern linguistics and the linguistic turn of western philosophy, various linguistic theories have been advanced and have given different interpretations to language and discourse. Different schools of thought have witnessed a direct collision of ideas and a deep academic dialogue between the theory of translinguistics advanced by the great master of dialogism, Bakhtin, and the outlook on language of the father of modern linguistics, Saussure.
Changes in Body Composition and Neuromuscular Performance Through Preparation, 2 Competitions, and a Recovery Period in an Experienced Female Physique Athlete
Authors: Tinsley Grant M. , Trexler Eric T. , Smith-Ryan Abbie E. , Paoli Antonio , Graybeal Austin J. , Campbell Bill I. , Schoenfeld Brad J. 
Published: July 2018

Abstract
Tinsley, GM, Trexler, ET, Smith-Ryan, AE, Paoli, A, Graybeal, AJ, Campbell, BI, and Schoenfeld, BJ. Changes in body composition and neuromuscular performance through preparation, two competitions, and a recovery period in an experienced female physique athlete. J Strength Cond Res 33(7): 1823–1839, 2019—This prospective case study evaluated an experienced female figure competitor during contest preparation, 2 competitions, and a recovery period. Twelve laboratory sessions were conducted over 8 months. At each visit, body composition was assessed by 4-compartment model, resting metabolic rate (RMR) by indirect calorimetry, and neuromuscular performance by peak force and rate of force development (RFD) on a mechanized squat device. Caloric intake ranged from 965 to 1,610 kcal·d−1 (16.1–24.8 kcal·kg·BM−1; 18.2–31.1 kcal·kg·FFM−1), with varying macronutrient intakes (CHO: 0.3–4.8 g·kg−1; PRO: 1.7–3.0 g·kg−1; and FAT: 0.2–0.5 g·kg−1). Body fat was reduced from 20.3 to 12.2% before the first competition and declined to 11.6% before the second competition. Fat-free mass increased by 2.1% before the first competition and peaked at 4.6% above baseline in the recovery period. Resting metabolic rate decreased from 1,345 kcal·d−1 at baseline to a low value of 1,119 kcal·d−1 between competitions. By the end of recovery, RMR increased to 1,435 kcal·d−1. Concentric and eccentric peak forces declined by up to 19% before the first competition, experienced perturbations in the inter-competition and recovery periods, and remained 5–8% below baseline at study termination. Similarly, RFD decreased by up to 57% before the first competition, was partially recovered, but remained 39% lower than baseline at study termination. Despite favorable body composition changes, neuromuscular performance was impaired during and after the competitive season in an experienced female physique competitor.
Socialinis ir emocinis ugdymas: mokytojo perspektyva
Authors: Venslovaitė Vita , Danylienė Laura 
Published: July 2018

[straipsnis lietuvių kalba; santrauka ir reikšminiai žodžiai anglų kalba]
Straipsnyje, remiantis mokslinės literatūros analize, pristatomi teoriniai socialinio ir emocinio ugdymo (toliau – SEU) bei emocinio intelekto aspektai ir atskleidžiama SEU reikšmė bei išryškinamas mokytojo vaidmuo diegiant socialinį ir emocinį ugdymą Lietuvos mokyklose. Remiantis tyrimo rezultatais, atskleidžiamas mokytojų, tiek dirbančių su SEU programomis, tiek ir nedirbančių su jomis, požiūris į SEU, jų galimybės ir pasirengimas dirbti su šiomis programomis. Mokytojai įvardija galimus iššūkius ir pateikia siūlymų, kaip sėkmingai įgyvendinti SEU. Empirinio tyrimo rezultatai atskleidžia galimus SEU vykdymo sunkumus, tačiau kartu gauta nemažai siūlymų, kurie padėtų tobulinti SEU įgyvendinimą.
Toward a Broader Understanding: A Formal Concept Analysis of the Micropolitics of a School
Authors: Kairienė Aida 
Published: July 2018

[full article in English]
The micropolitics of a school is one of the key factors that determine changes in member interactions in a learning organization and requires a careful study in order to create a favorable school environment. The aim of this study is to analyze the concept of the micropolitics of a school, highlighting the essential attributes of the concept. The research method – Formal Concept Analysis (FCA) – was used to identify the implicit relationships between objects described through a set of the attributes. The analysis of scientific literature reveals 6 sets of objects: micropolitics as a dimension of leadership; micropolitics as a part of macropolitics; micropolitics as a teacher’s life and actions; micropolitics as interactions within an organization; micropolitics as the daily life of an organization; micropolitics as the darker side of institutional life.
Physiological adaptations to specific endurance training in professional female handball players
Authors: Gabnai SG , Kósa L , Tóth E , Schulteisz N , Gangl J , Othman M , Ihász F 
Published: July 2018

Several Hungarian and foreign researchers have already studied the cardiorespiratory parameters of elite handball players. There are only a few studies though, which would separately review the changes in the functions of different organ systems. The aim of this study is to investigate the effect of an intervention (physical activity) on the cardiorespiratory system. In this study, 16 elite female handball players participated, whose body compositions were measured and took two vita maxima tests. During the analysis, each cardiorespiratory parameter was monitored for every 20 s. Between the two examinations, 6 weeks passed and an intervention took place. There was a significant decrease in relative body fat and a significant increase in relative muscle mass. Remarkable positive changes occurred in the values of ventilation, oxygen pulse, and in both absolute and relative aerobic capacities as well. The mean values of the team developed as expected, but the individual changes in body composition and cardiorespiratory parameters are just as important. First, we chose four players, who had the most outstanding changes. Second, we analyzed such parameters, which were expected to show adequate results in terms of the apparatus(es) functioning.
Botanikai adatok Tolnából és Baranyából III.
Authors: Tóth István Zsolt 
Published: July 2018

A legutóbbi publikációm óta eltelt 4 év alatt (2014–2017) a Duna–Dráva Nemzeti Park számára összegyűjtött 25 000 adatomból válogatva közlök értékes és érdekes botanikai adatokat 116 taxonról, például a fokozottan védett Digitalis ferruginea és Paeonia banatica, a védett Polystichum lonchitis, Dryopteris affinis, Doronicum orientale, Helleborus dumetorum, Corydalis intermedia, Spiraea media és Veratrum nigrum, valamint a nem védett, de ritka Lycopsis arvensis, Silene dichotoma, Teucrium botrys, Thladiantha dubia, Vicia lutea és Hypochoeris radicata új előfordulásairól. Pár érdekességet is megemlítek, pl. a legnagyobb (és föltételezhetően legidősebb) Crataegus monogyna, Hedera helix, Ruscus hypoglossum és R. aculeatus egyedek méretét, amelyekkel a több ezer hektár bejárása során találkoztam.
Surgical treatment of the tumors of the fourth ventricle through telovelar approach
Authors: Kalinovskiy A. V. , Chernov S. V. , Zotov A. V. , Kasymov A. R. , Gormolysova E. V. , Uzhakova E. K. 
Published: July 2018

The study objectiveis analysis of surgical treatment results of adult patients with tumors of the fourth ventricle and determination of predictors of unsuccessful outcomes.Materials and methods.In the present study we review results of treatment of 33 adult patients with tumors of the fourth ventricle, which were operated via telovelar approach in Federal Neurosurgical Center (Novosibirsk). The most common symptoms included hydrocephalus (54.5 %), cerebellar dysfunction (33.3 %), cranial nerve deficits (30.3 %). The tumor size was more than 40 mm in 22 cases (66.7 %). The brain stem invasion was occurred in 21 cases (63.6 %).Results.23 tumors were removed totally (69.7 %). Hydrocephalus was regressed in 17 cases (94.5 %). Cerebellar mutism did not occur in any patient. Conclusion.Predictors of poor result may be brain stem invasion, non-radical resection of tumor and preoperative hydrocephalus. We suggest, that the preoperative hydrocephalus should not been operated in the most cases of the fourth ventricular tumors.
VIMENTIN EXPRESSION IN HUMAN CELL LINES OF EPITHELIAL TUMORS
Authors: Bogush T. A. , Kaliuzhny S. A. , Chetyrkina M. R. , Yastrebova M. A. , Scherbakov A. M. , Mamichev I. A. , Kamensky А. А. 
Published: July 2018

Background.Cell cultures used as a models in studies of epithelial tumors, are obtained not only from solid tumors, but also from extracellular fluids. It is known that dissemination of ovarian cancer in the peritoneum and further growth of tumor cells in ascetic liquid is accompanied with the activation of epithelial-mesenchymal transition, and, therefore, cell cultures derived from extracellular fluids can have a distinct molecular phenotype from primary tumors.Objective:evaluation the “persistence” of epithelial phenotype in breast and ovarian cancer cell cultures.Materials and methods.The cells obtained from pleural fluid (MCF-7, T-47D), colostrum (HBL-100), solid tumors (BT-474, HCC1937) of patients with breast cancer and ascitic fluid (SCOV- 3) of patients with ovarian cancer. The expression of cytokeratins and vimentin was evaluated using a quantitative immunofluorescence method associated with flow cytometry.Results.Vimentin expression in cells derived from extracellular fluids was not changed (line HBL-100), slightly decreased (SCOV-3 cells), or even was lost (MCF-7 and T-47D cells). HCC1937 cells obtained from solid tumor with expected low expression of vimentin acquired a molecular phenotype with a high expression of this mesenchymal marker. In breast cancer cells BT-474 derived from solid tumor a “persistence” of epithelial phenotype was discovered.Conclusion.Quantitative assessment of the de novo expression of mesenchymal protein vimentin showed that the tumor phenotype within the organizm is not always realized in cells adapted to growth in culture, and is not always «strictly» epithelial, and this evidence must be considered with different kinds of molecular studies of epithelial cells in vitro.
THE INFLUENCE OF PROPIONATE ON THE SPECTRUM OF LONG-CHAIN FATTY ACIDS IN CERVICAL CELLS DURING DIS- AND NEOPLASTIC TRANSFORMATION
Authors: Kayukova E. V. , Belokrinitskaya T. E. , Tereshkov P. P. 
Published: July 2018

Background.Metabolic reprogramming of tumor cells is one of the leading links in carcinogenesis. The objective to confirm the hypothesis of a propionate pathway for the synthesis of long-chain acids with an odd number of carbon atoms in cervical cancer.Materials and methods.As samples for the study were biopsies of the colli uteri, from which a suspension of tumor cells was obtained (20 – cervical cancer, 20 – cervical intraepithelial neoplasia III grade, 18 – endocervical scraping from healthy women). The spectrum of fatty acids (FA) was analyzed before, after 24 hours incubation without and with 50 μmol/l propionic acid by the gas chromatography method.Results.Metabolism of FA is multidirectional in different locus in cervical cancer. In the locus of cervical cancer, most likely, there is a propionic pathway for the synthesis of FA using palmitate. In cervical intraepithelial neoplasia III grade, the metabolism of FA is another. Palmitic acid was used for synthesis stearate, which was metabolized to oleic acid.Сonclusion.The specificity of biochemical changes within one organ and one pathology has been revealed, which reflects the stage-by-stage development of the oncological process.