bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluación de la función sexual en pacientes con obesidad, antes y después de la cirugía bariátrica
Authors: Silva José Miguel , Puerto Niño Angie , Duarte Andrés , Vargas Isis , Sánchez Basto Catalina 
Published: December 2018

Introducción La obesidad afecta diversos aspectos físicos, psicológicos y sociales. Recientemente se ha comenzado a estudiar su relación con la función sexual y el efecto de las intervenciones dirigidas a reducir el peso.
Objetivo Describir los cambios inducidos por la cirugía bariátrica en la función sexual en un grupo de pacientes obesos.
Métodos Estudio observacional prospectivo de pacientes con obesidad mórbida, intervenidos con cirugía bariátrica. Se evaluó la función sexual en hombres con el cuestionario abreviado de función sexual (SHIM) y la encuesta de autoestima y relaciones (SEAR), y en mujeres con el Índice de función sexual femenina (IFSF). La calidad de vida se evaluó con el cuestionario SF-12. Se utilizaron pruebas estadísticas no paramétricas.
Resultados Se incluyeron 19 pacientes, 13 mujeres con un promedio de edad de 45,3 años (22–59) y 6 hombres con un promedio de 41 años (36–54). El seguimiento promedio fue de 19 meses (13,1–25,9). Para el IFSF, todos los dominios demostraron mejoría, aunque la variable deseo fue la única en la que se obtuvo una diferencia estadísticamente significativa (p = 0.027). Los puntajes obtenidos con la escala SHIM, demuestran disminución en la severidad de la disfunción eréctil de 16,8 (8–21) a 22,16 (18–25) (p = 0,059). En calidad de vida, tanto mujeres como hombres reportaron un incremento estadísticamente significativo (p = 0.036 y p = 0.002, respectivamente).
Conclusiones La cirugía bariátrica tiene un impacto altamente favorable en la calidad de vida y cambios positivos en todos los dominios de la función sexual de hombres y mujeres. Es posible que esos cambios se vean influidos por variables físicas y psicosociales que deben medirse con investigaciones futuras.
Electrophysiological Responses to Different Follicle-Stimulating Hormone Isoforms on Human Cumulus Oophorus Cells: Preliminary Results
Authors: Loss Eloísa da Silveira , Ayres Laura Silveira , Bos-Mikich Adriana , Frantz Nilo , Arruda Letícia Schmidt 
Published: December 2018

Objective The aim of the present study was to provide a better understanding of the specific action of two follicle-stimulating hormone (FSH) isoforms (β-follitropin and sheep FSH) on the membrane potential of human cumulus cells.
Methods Electrophysiological data were associated with the characteristics of the patient, such as age and cause of infertility. The membrane potential of cumulus cells was recorded with borosilicate microelectrodes filled with KCl (3 M) with tip resistance of 15 to 25 MΩ. Sheep FSH and β-follitropin were topically administered onto the cells after stabilization of the resting potential for at least 5 minutes.
Results In cumulus cells, the mean resting membrane potential was - 34.02 ± 2.04 mV (n = 14). The mean membrane resistance was 16.5 ± 1.8 MΩ (n = 14). Sheep FSH (4 mUI/mL) and β-follitropin (4 mUI/mL) produced depolarization in the membrane potential 180 and 120 seconds after the administration of the hormone, respectively.
Conclusion Both FSH isoforms induced similar depolarization patterns, but β-follitropin presented a faster response. A better understanding of the differences of the effects of FSH isoforms on cell membrane potential shall contribute to improve the use of gonadotrophins in fertility treatments.
Bunte neue Arbeitswelt
Authors: Fastenmeier Heribert 
Published: December 2018

Zusammenfassung
Flexible Arbeitszeiten liegen voll im Trend. Auch im Krankenhaus halten
sie zunehmend Einzug. Das Klinikum Ingolstadt etwa bietet eine Reihe von
unterschiedlichen Modellen an. Sie bergen enormes Potenzial – für die
Mitarbeiter und das Unternehmen.
Wie Gefährdungsanzeigen überflüssig werden
Authors: Leydecker Julia , Kutscher Jan 
Published: December 2018

ZusammenfassungWie die Erfahrung zeigt, bringen Gefährdungsanzeigen meist nicht den erwünschten Effekt – für keinen der Beteiligten. Besser wäre
also, sie entstünden erst gar nicht. Lesen Sie im zweiten Teil mehr über die Vier-Säulen-Strategie unserer Autoren, die
Gefährdungsanzeigen überflüssig machen soll.
Streptomyces
spp. as biocontrol agents against
Fusarium
species.
Authors: Bubici G. 
Published: December 2018

Abstract

Streptomycetes are the largest taxon of antibiotic producers in the microbial world. Nevertheless, they are less studied than other biocontrol agents against Fusarium diseases and, perhaps, plant diseases in general. Plant diseases incited by
Fusarium
species are notably challenging. Four species complexes in the genus are pathogenic:
Fusarium fujikuroi
,
F. graminearum
,
F. solani
and
F. oxysporum
. Being a vascular pathogen,
F. oxysporum
is particularly difficult to control by using microbial antagonists. Most research has remained at early experimental stages, and only few
Streptomyces
spp. strains have been assayed under diverse conditions. Few commercial products consisting of
Streptomyces
spp. have often provided fluctuating results across trials. Five biocontrol trials conducted in the field using streptomycetes report reductions of diverse Fusarium wilts by 0-55%, with one case (cucumber) of yield increase by 1.3-fold. Among 38 articles dealing with pot-experiments, 16 report a disease control level above 50%, seven of which with a level above 70%. The chitinolytic activity of
Streptomyces
spp. strains plays an important role in the biocontrol of Fusarium diseases, and the plant growth promotion trait is a cherished outcome. More attention is being paid to strains endophytic, producing volatile organic compounds, or to the identification of antibiotics and metabolites responsible for the biocontrol. Bioformulation is a critical point in the use of biocontrol agents, but it has been still poorly considered in the experiments. The biocontrol efficacy of well-designed streptomycete consortia or the so-called microbial synthetic communities, possibly in proper bioformulations, and the role of streptomycetes in the reduction of mycotoxins in the grains are aspects that would merit further investigation in the future.
Babesiosis-associated Splenic Rupture: Case Series From a Hyperendemic Region
Authors: Patel Kavin M , Johnson Jennie E , Reece Rebecca , Mermel Leonard A 
Published: December 2018

Abstract

Background
Spontaneous splenic rupture is an increasingly reported complication of babesiosis and has been described as a severe complication.

Methods
We performed a retrospective chart review in a high-prevalence area to identify 7 cases of babesiosis-related splenic rupture between 2014 and 2016.

Results
Splenic rupture occurred in approximately 1% of babesiosis cases. Compared to cases without splenic rupture, these patients were younger (by &gt;10 years), healthier (most with ≤1 comorbidity), had a lower degree of parasitemia (&lt;10%), and were less likely to have end-organ dysfunction other than their splenic involvement.

Conclusions
Younger, healthier patients may be more prone to develop splenic rupture, as splenic histiocytes engage in more robust erythrophagocytosis, leading to pathological mechanical strain and rupture.
Mucosal Healing and Bacterial Composition in Response to Enteral Nutrition Vs Steroid-based Induction Therapy—A Randomised Prospective Clinical Trial in Children With Crohn’s Disease
Authors: Pigneur Bénédicte , Lepage Patricia , Mondot Stanislas , Schmitz Jacques , Goulet Olivier , Doré Joël , Ruemmele Frank M 
Published: December 2018

AbstractAimsExclusive enteral nutrition [EEN] is as efficacious as corticosteroids [CS] to induce remission in Crohn’s disease [CD], without their adverse effects. EEN seems to be more efficient than steroids to induce mucosal healing, but the underlying molecular mechanisms are only sparsely understood. We aimed in the present work to study the anti-inflammatory effects of EEN with Modulen IBD® vs CS in active paediatric CD, and to assess its modulatory effects on the intestinal microbiota as compared with steroids.Materials and MethodsNineteen patients with new-onset active CD (Harvey-Bradshaw index [HBI] >5), aged from 6 to 17 years, were included in this prospective randomised induction trial with CS [n = 6] or EEN [n = 13]. Patients were assessed at Weeks 0 and 8 using clinical parameters HBI, endoscopic findings (Crohn’s Disease Endoscopic Index of Severity [CDEIS] score) and analysis of faecal microbiota composition.ResultsAt 8 weeks, clinical remission [HBI <5] was achieved in 13/13 patients on EEN and 5/6 patients on steroids; the mucosal healing rate was significantly higher in the EEN [89%] compared with steroid group [17%]. There were no significant differences between groups regarding biological markers, but the intestinal microbiota profiles shifted upon EEN-induced remission to a higher proportion of Ruminococcus bacteria compared with steroid-induced remission [p = 0.049], and with higher proportions of bacteria belonging to Clostridium in EEN-treated patients.ConclusionsBoth steroid and EEN induced clinical remission. However, patients with EEN-induced remission showed a higher rate of mucosal healing and this was associated with a different gut microbiota compositional shift in these children.
Critical success factors of public health sponsorship in Australia
Authors: Sung Billy , Phau Ian , Cheah Isaac , Teah Kevin 
Published: December 2018

Abstract
Public health sponsorship is a unique phenomenon in Australia. The current research examines the critical success factors of Western Australian Health Promotion Foundation’s (Healthway) sponsorship program, Australia’s largest public health sponsorship program. Using stakeholder interviews and expert observational studies, two studies present five key success factors: (i) effective segmentation and targeting of health messages; (ii) collaboration between Healthway and partnering organization to leverage sponsored events; (iii) displacement of unhealth sponsorship; (iv) use of leveraging strategies to raise awareness of health messages; and (v) environmental changes that facilitate behavioural change. The current research provides insights into how and why sponsorship is an effective public health promotion tool.
Performance of bleeding risk scores in dialysis patients
Authors: Ocak Gurbey , Ramspek Chava , Rookmaaker Maarten B , Blankestijn Peter J , Verhaar Marianne C , Bos Willem Jan W , Dekker Friedo W , van Diepen Merel 
Published: December 2018

Abstract

Background
Bleeding risk scores have been created to identify patients with an increased bleeding risk, which could also be useful in dialysis patients. However, the predictive performances of these bleeding risk scores in dialysis patients are unknown. Therefore, the aim of this study was to validate existing bleeding risk scores in dialysis patients.

Methods
A cohort of 1745 incident dialysis patients was prospectively followed for 3 years during which bleeding events were registered. We evaluated the discriminative performance of the Hypertension, Abnormal kidney and liver function, Stroke, Bleeding, Labile INR, Elderly and Drugs or alcohol (HASBLED), the AnTicoagulation and Risk factors In Atrial fibrillation (ATRIA), the Hepatic or kidney disease, Ethanol abuse, Malignancy, Older age, Reduced platelet count or Reduced platelet function, Hypertension, Anaemia, Genetic factors, Excessive fall risk and Stroke (HEMORR2HAGES) and the Outcomes Registry for Better Informed Treatment (ORBIT) bleeding risk scores by calculating C-statistics with 95% confidence intervals (CI). In addition, calibration was evaluated by comparing predicted and observed risks.

Results
Of the 1745 dialysis patients, 183 patients had a bleeding event, corresponding to an incidence rate of 5.23/100 person-years. The HASBLED [C-statistic of 0.58 (95% CI 0.54–0.62)], ATRIA [C-statistic of 0.55 (95% CI 0.51–0.60)], HEMORR2HAGES [C-statistic of 0.56 (95% CI 0.52–0.61)] and ORBIT [C-statistic of 0.56 (95% CI 0.52–0.61)] risk scores had poor discriminative performances in dialysis patients. Furthermore, the calibration analyses showed that patients with a low risk of bleeding according to the HASBLED, ATRIA, HEMORR2HAGES and ORBIT bleeding risk scores had higher incidence rates for bleeding in our cohort than predicted.

Conclusions
The HASBLED, ATRIA, HEMORR2HAGES and ORBIT bleeding risk scores had poor predictive abilities in dialysis patients. Therefore, these bleeding risk scores may not be useful in this population.
Complete Decongestive Therapy Is an Option for the Treatment of Rosacea Lymphedema (Morbihan Disease): Two Cases
Authors: Kutlay Sehim , Ozdemir Elif Can , Pala Zahide , Ozen Selin , Sanli Hatice 
Published: December 2018

Abstract

Background and Purpose
Morbihan disease, also known as rosacea lymphedema, is a rare persistent form of lymphedema that is associated with the disease rosacea. Even though acne rosacea responds well to standard medical treatment, the lymphedema component of the disease is resistant to both medical and surgical therapy. Complete decongestive therapy (CDT) can be considered as a conservative alternative option for treatment of rosacea lymphedema. To date, there is no report on the use of CDT in treating facial lymphedema secondary to acne rosacea.

Case Description
We present 2 cases of women with a diagnosis of Morbihan disease and chronic facial lymphedema that remained resistant to drug treatment for many years before CDT was offered. The treatment program included 4 components: manual lymphatic drainage, compression bandaging, exercises to enhance lymphatic drainage, and patient education.

Outcomes
Following 10 to 15 sessions of CDT, the first patient's facial edema had almost completely resolved. The second patient's response to treatment was assessed as moderate.

Discussion
To the best of our knowledge, these 2 cases of Morbihan disease treated with CDT are the first of their kind to be presented in the literature. As the treatment options for Morbihan disease remain inadequate, we believe that CDT should be considered as a treatment option in those patients who do not benefit from or refuse drug treatment, before moving on to more invasive procedures. Prospective studies should be designed to demonstrate the efficacy of CDT and provide management details.
Consumption Taxes and Corporate Investment
Authors: Jacob Martin , Michaely Roni , Müller Maximilian A 
Published: December 2018

AbstractConsumers nominally pay the consumption tax, but theoretical and empirical evidence is mixed on whether corporations partly shoulder this burden, thereby affecting corporate investment. Using a quasi-natural experiment, we show that consumption taxes decrease investment. Firms facing more elastic demand decrease investment more strongly, because they bear more of the consumption tax. We corroborate the validity of our findings using 86 consumption tax changes in a cross-country panel. We document two mechanisms underlying the investment response: reduced firms’ profitability and lower aggregate consumption. Importantly, the magnitude of the investment response to consumption taxes is similar to that of corporate taxes.Received September 25, 2017; editorial decision August 26, 2018 by Editor Wei Jiang. Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Comparative effectiveness of abatacept, rituximab, tocilizumab and TNFi biologics in RA: results from the nationwide Swedish register
Authors: Frisell Thomas , Dehlin Mats , Di Giuseppe Daniela , Feltelius Nils , Turesson Carl , Askling Johan ,   ARTIS Study Group, Ernestam Sofia , Klareskog Lars , Nisell Ralph , Baecklund Eva , Kastbom Alf , Jacobsson Lennart , Lindqvist Elisabet , d’Elia Helena Forsblad , Rantapää-Dahlqvist Solbritt 
Published: December 2018

AbstractObjectivesCurrent guidelines rank abatacept, rituximab, tocilizumab and TNF-inhibitors (TNFi) as having equal effectiveness for the treatment of RA, at least as second line therapies. These recommendations are mainly based on meta-analysis of randomized controlled trials, with few direct drug–drug comparisons. Our objective was to compare the real-world absolute and relative effectiveness among RA patients starting any of the available biologic DMARDs (bDMARDs).MethodsWe used the Swedish Rheumatology Register to identify patients with RA initiating TNFi, rituximab, abatacept or tocilizumab in 2010–2016 as first bDMARD (n = 9333), or after switch from TNFi as first bDMARD (n = 3941). National Swedish registers provided additional covariates and censoring events. Effectiveness was assessed 3 and 12 months after treatment start, as the proportion remaining on therapy and with EULAR Good Response, HAQ improvement >0.2, zero swollen/tender joints and CDAI remission. Adjusted differences were estimated with multivariable linear regression.ResultsPatients starting non-TNFi (vs TNFi) as first bDMARD had a higher proportion remaining on drug and reaching most response outcomes as first bDMARD (1-year EULAR Good Response/HAQ improvement: TNFi 24.9/25.4%, rituximab 28.6/37.2%, abatacept 31.9/33.7%, tocilizumab 50.9/43.1%). After switch from a first TNFi, rituximab and tocilizumab, but not abatacept, were associated with significantly better response measures than TNFi (1-year EULAR Good Response/HAQ improvement: TNFi 11.6/16.1%, rituximab 24.8/33.2%, abatacept 13.1/17.5%, tocilizumab 34.1/29.4%). Differences remained significant after adjusting for potential confounders.ConclusionTreatment outcomes among RA patients treated in Swedish clinical practice are in line with a superior effectiveness of non-TNFi bDMARDs, in particular tocilizumab and rituximab, compared with TNFi.
BAYESIAN SPECTRUM DECONVOLUTION INCLUDING UNCERTAINTIES AND MODEL SELECTION: APPLICATION TO X-RAY EMISSION DATA USING WINBUGS
Authors: Behrens R , Reginatto M 
Published: December 2018

AbstractSpectrum deconvolution is an important task in ionizing radiation measurements, as the pulse height spectra, or, in general, the measured data from spectrometers or other measuring instruments are usually determined by the convolution of the response function with the fluence spectra. The method presented here for obtaining fluence spectra from the measurements is an application of Bayesian parameter estimation to the deconvolution of X-ray emission data. The problem of choosing the optimal model among several possible models is also considered, as well as an approach to include contributions from various sources of uncertainty, both correlated and uncorrelated. The application is carried out using the Bayesian software WinBUGS.
Social Class, Gender, and Contemporary Parenting Standards in the United States: Evidence from a National Survey Experiment
Authors: Ishizuka Patrick 
Published: December 2018

AbstractSocial scientists have documented a substantial increase in both mothers’ and fathers’ time spent with children since the 1960s in the United States. Yet parenting behaviors remain deeply divided by social class and gender, with important implications for the reproduction of inequality. To understand rising parental investments in children and persistent class and gender differences in parenting, popular accounts and academic studies have pointed to an apparent cultural shift toward norms of time-intensive, child-centered parenting, particularly for mothers and among middle-class parents. However, prior research has produced inconclusive evidence relating to social class, gender, and contemporary parenting norms. Using data from an original vignette survey experiment conducted with a nationally representative sample of more than 3,600 parents, this study examines cultural norms related to parenting elementary school-aged children, considering how both social class and gender shape views about good parenting. Results indicate that parents of different social classes express remarkably similar support for intensive mothering and fathering across a range of situations, whether sons or daughters are involved. These findings suggest that cultural norms of child-centered, time-intensive mothering and fathering are now pervasive, pointing to high contemporary standards for parental investments in children.
Duration of Scar Maturation: Retrospective Analyses of 361 Hypertrophic Scars Over 5 Years
Authors: Kant Sander , van den Kerckhove Eric , Colla Carlo , van der Hulst René , Piatkowski de Grzymala Andrzej 
Published: December 2018

ABSTRACT

OBJECTIVE:
Maturation remains the least understood phase of wound healing; estimates of maturation time are broad and inaccurate. A more precise estimation of maturation time could influence scar therapy and give insight to the wound healing cascade. The objective of this study was to assess the mean time between onset and complete maturation of hypertrophic scars.

METHODS:
This retrospective study was performed in an outpatient clinic of the Maastricht University Medical Center exclusively focused on scar treatment; 361 patients with a hypertrophic scar were included between September 2010 and December 2015.

MAIN OUTCOME MEASURES:
Date of onset and date of complete maturation were documented in patients’ medical files. Patients were divided into three patient groups: <30 years, 30–55 years, and >55 years. Different scar causes and scar therapies were analyzed in relation to maturation time.

MAIN RESULTS:
These results reveal statistically significant differences (P < .05) in mean maturation time between the <30 (35.76 months) and >55 patients (22.53 months) and between >55 and 30–55 year old patients (34.64 months). Significant differences in mean maturation time were also found between scars treated with pressure therapy (23.20 months) and combination therapy (30.59 months), silicone therapy (35.51 months), injection therapy (46.43 months), and other therapies (41.31 months). No significant differences in maturation time were found relative to scar cause.

CONCLUSIONS:
This study shows that hypertrophic scars take significantly more time to completely maturate than previously believed, and older patients show the fastest healing. Further, scars treated with pressure therapy maturate fastest.
A Systematic Review of Development Programs Designed to Address Leadership in Academic Health Center Faculty
Authors: Moore Simas Tiffany A. , Cain Joanna M. , Milner Robert J. , Meacham Martha E. , Bannon Annika L. , Levin Leonard L. , Amir Nili , Leung Katherine , Ockene Judith K. , Thorndyke Luanne E. 
Published: December 2018

Introduction:
To describe Academic Health Center (AHC) faculty leadership development program characteristics and categorize leadership topics into thematic areas suggesting competency domains to guide programmatic curricular development.

Methods:
A systematic literature review was conducted (PubMed/MEDLINE, Scopus, Cumulative Index of Nursing and Allied Health Literature [CINAHL], and Journal Storage [JSTOR databases]). Eligible studies described programs with leadership development intent for faculty in AHCs. Information was extracted using a structured data form and process.

Results:
Six hundred ninety citations were screened; 25 publications describing 22 unique programs were eligible. The majority (73%) were institutionally based; mean class size was 18.5 (SD ± 10.2, range 4.5–48); and mean in-person time commitment was 110 hours (SD ± 101.2, range 16–416), commonly occurring in regular intervals over months to years (n = 10, 45%). Six programs provided per participant costs (mean $7,400, range $1000–$21,000). Didactic teaching was the primary instructional method (99.5%); a majority (68%) included project work. Fourteen thematic content areas were derived from 264 abstracted topics. The majority or near majority incorporated content regarding leadership skills, organizational strategy and alignment, management, self-assessment, and finance/budget.

Discussion:
Institutions and faculty invest significantly in leadership development programs, addressing perceived needs and with perceived benefit for both. The prevalence of common curricular content indicates that AHCs deem important faculty development in leadership, business, and self-assessment skills.