bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of ANGIOGENIN, or lack thereof, in the generation of stress-induced tRNA halves and of smaller tRNA fragments that enter Argonaute complexes
Authors: Su Zhangli , Kuscu Canan , Malik Asrar , Shibata Etsuko , Dutta Anindya 
Published: August 2019

ABSTRACTOverexpressed Angiogenin (ANG) cleaves tRNA anticodons to produce tRNA halves similar to those produced in response to stress, but it is not clear whether endogenous ANG is essential for producing the stress-induced tRNA halves. It is also not clear whether smaller tRNA fragments (tRFs) are generated from the tRNA halves. Global short RNAseq experiments reveal that ANG over-expression selectively cleaves a subset of tRNAs (tRNAGlu, tRNAGly, tRNALys, tRNAVal, tRNAHis, tRNAAspand tRNASeC) to produce tRNA halves and 26-30 bases long tRF-5s. Surprisingly, knockout of ANG reveals that the majority of stress-induced tRNA halves except 5’ half from tRNAHisGTGand 3’ half from tRNAAspGTCare ANG-independent, suggesting there are other RNases that can produce tRNA halves. The 17-25 bases long tRF-3s and tRF-5s that could enter into Argonaute complexes are not induced by ANG overexpression, suggesting that they are generated independently from tRNA halves. Consistent with this, knockout of ANG did not decrease tRF-3 levels or gene-silencing activity. Therefore ANG cleaves specific tRNAs, is not the only RNAse that creates tRNA halves and the shorter tRFs are not generated from the tRNA halves or from independent tRNA cleavage by ANG.
How to make methodological decisions when inferring social networks
Authors: Ferreira André C. , Covas Rita , Silva Liliana R. , Esteves Sandra C. , Duarte Inês F. , Fortuna Rita , Theron Franck , Doutrelant Claire , Farine Damien R. 
Published: August 2019

ABSTRACTConstructing and analysing social networks data can be challenging. When designing new studies, researchers are confronted with having to make decisions about how data are collected and networks are constructed, and the answers are not always straightforward. The current lack of guidance on building a social network for a new study system might lead researchers to try several different methods, and risk generating false results arising from multiple hypotheses testing. We suggest an approach for making decisions when developing a network without jeopardising the validity of future hypothesis tests. We argue that choosing the best edge definition for a network can be made using a priori knowledge of the species, and testing hypotheses that are known and independent from those that the network will ultimately be used to evaluate. We illustrate this approach by conducting a pilot study with the aim of identifying how to construct a social network for colonies of cooperatively breeding sociable weavers. We first identified two ways of collecting data using different numbers of feeders and three ways to define associations among birds. We then identified which combination of data collection and association definition maximised (i) the assortment of individuals into ‘breeding groups’ (birds that contribute towards the same nest and maintain cohesion when foraging), and (ii) socially differentiated relationships (more strong and weak relationships than expected by chance). Our approach highlights how existing knowledge about a system can be used to help navigate the myriad of methodological decisions about data collection and network inference.SIGNIFICANCE STATEMENTGeneral guidance on how to analyse social networks has been provided in recent papers. However less attention has been given to system-specific methodological decisions when designing new studies, specifically on how data are collected, and how edge weights are defined from the collected data. This lack of guidance can lead researchers into being less critical about their study design and making arbitrary decisions or trying several different methods driven by a given preferred hypothesis of interest without realising the consequences of such approaches. Here we show that pilot studies combined with a priori knowledge of the study species’ social behaviour can greatly facilitate making methodological decisions. Furthermore, we empirically show that different decisions, even if data are collected under the same context (e.g. foraging), can affect the quality of a network.
Protocol development for discovery of angiogenesis inhibitors via automated methods using zebrafish
Authors: Mauro Antonio , Ng Robin , Li Jamie Yuanjun , Guan Rui , Wang Youdong , Singh Krishna Kumar , Wen Xiao-Yan 
Published: August 2019

AbstractTheir optical clarity as larvae and embryos, small size, and high fecundity make zebrafish ideal for whole animal high throughput screening. A high-throughput drug discovery platform (HTP) has been built to perform fully automated screens of compound libraries with zebrafish embryos. A Tg(Flk1:EGFP) line, marking endothelial cell cytoplasm, was used in this work to help develop protocols and functional algorithms for the system, with the intent of screening for angiogenesis inhibitors. Indirubin 3’ Monoxime (I3M), a known angiogenesis inhibitor, was used at various concentrations to validate the protocols. Consistent with previous studies, a dose dependant inhibitory effect of I3M on angiogenesis was confirmed. The methods and protocols developed here could significantly increase the throughput of drug screens, while limiting human errors. These methods are expected to facilitate the discovery of novel anti-angiogenesis compounds and can be adapted for many other applications in which samples have a good fluorescent signal.
Pragmatic selection of larval mosquito diets for insectary rearing ofAnopheles gambiaeandAedes aegypti
Authors: Benedict Mark Q. , Hunt Catherine M. , Vella Michael G. , Gonzalez Kasandra M. , Dotson Ellen M. , Collins C. Matilda 
Published: August 2019

AbstractLarval mosquitoes are aquatic omnivorous scavengers which scrape food from submerged surfaces and collect suspended food particles with their mouth brushes. The composition of diets that have been used in insectaries varies widely though necessarily provides sufficient nutrition to allow colonies to be maintained. Issues such as cost, availability and experience influence which diet is selected. One component of larval diets, essential fatty acids, appears to be necessary for normal flight though deficiencies may not be evident in laboratory cages and are likely more important when mosquitoes are reared for release into the field in e.g. mark-release-recapture and genetic control activities.In this study, four diets were compared for rearingAnopheles gambiaeandAedes aegypti, all of which provide these essential fatty acids. Two diets were custom formulations specifically designed for mosquitoes (Damiens) and two were commercially available fish foods: Doctors Foster and Smith Koi Staple Diet and TetraMin Plus Flakes. Development rate, survival, dry weight and adult longevity of mosquitoes reared with these four diets were measured. The method of presentation of one diet, Koi pellets, was additionally fed in two forms, pellets or a slurry, to determine any effect of food presentation on survival and development rate.While various criteria might be selected to choose ‘the best’ food, the readily-available Koi pellets resulted in development rates and adult longevity equal to the other diets, high survival to the adult stage and, additionally, this is available at low cost.
The role of accounting in mediating empathic care for the “other”
Authors: Dellaportas Steven 
Published: August 2019

Purpose
This paper hypothesizes that a system of accounting underpinned by attributions of harm has the capacity, more than conventional accounting, to elicit empathic concern among managers, by becoming the mediating link between organisational responsibility and concern for the “other”.

Design/methodology/approach
The literature-inspired reflections presented in this paper stem from the theoretical perspective of care-ethics supported by the notions of empathy and proximity to highlight how the propensity to empathise is mediated by attributions of harm and responsibility.

Findings
The proposed “new” accounting, coined “connected accounting” is proposed because of its potential to make visible the neglected and marginalised segments of society that presently lie hidden in conventional accounting. Accounting for the effects of organisational practice on people and society is expected to strengthen the care-ethic relationship between key actors – managers, accountants and stakeholders.

Research limitations/implications
The paper is limited by the assumptions that underpin the conceptualised notion of “Connected Accounting”.

Originality/value
This essay introduces to the accounting ethics literature the role of emotion and empathic care in accounting, including sociological aspects of accounting reflecting the ongoing quest for understanding the processes and consequences of accounting as a social practice.
Investigation of graphene effect on the anti-corrosion behaviour of polyurethane coatings in sea-water
Authors: Tan Hai , Wang Deguo , Guo Yanbao 
Published: August 2019

Purpose
Abundant oil and gas reservoirs in the deep-water are the valuable non-renewable energy sources. However, sea-water could enhance the corrosion of marine equipment such as submarine pipe trees. Various coatings, for example, polyurethane (PU) coatings are sprayed on the steel surfaces to enhance the anti-corrosion performance. Thus, to improve the anti-corrosion behavior of PU coatings in sea-water is imperative.

Design/methodology/approach
In this paper, the corrosion behaviors of 4130 carbon steel with and without PU coatings were discussed by electrochemical mean in sea-water. And the graphene additive in different concentrations (0.1, 0.3, 0.6 and 0.9 per cent) were also studied. A series of characterized methods were introduced to identify the anti-corrosion performances of 4130 carbon steel with and without coatings, respectively.

Findings
The results showed that the anti-corrosion property of 4130 carbon steel can enhance obviously with the PU coatings. The graphene additive can further improve the anti-corrosion behaviour of PU coatings and in the concentration of 0.6 per cent the PU/graphene coatings worked best.

Originality/value
This is beneficial for enhancing the service life of marine equipment in an eco-friendly method.
Reliability model and probability analysis method for pitting corrosion under mechanical loading
Authors: Liu Xiaoxiao , Liu Ming 
Published: August 2019

PurposeCorrosion is one of the common damage mechanisms in many engineering structures such as marine structures, petroleum pipelines, aerospace and nuclear reactor. However, the service performance of metal materials and structures is gradually degenerating with the increase of service life due to the rapid growth of corrosion damages. Thus, the coupled effects for corrosion damage in reliability analysis should be considered urgently. Then, the purpose of this paper is to develop the corrosion damage physical model and the corresponding reliability analysis methods, which consider the coupled effect of corrosion damage.Design/methodology/approachA failure physical model, considering the coupled effect of pitting growth, crack and crack propagation, is presented in this paper. Sequentially, the corrosion reliability with respect to pitting physical damage can be investigated. The presented pitting damage physical model is formulated as time-variant performance limit state functions, which include the crack transition, crack growth and fracture failure mechanics. The first-passage failure criterion is used to construct the corrosion reliability framework, involving in the pitting damage model with the increase of service life.FindingsResults demonstrate that the multiplicative dimensional reduction (MDR) method behaves much better than FORM no matter in accuracy or efficiency. The proposed corrosion reliability method is applicable for dealing with the damage failure model of the structural pitting corrosion.Originality/valueThe MDR method is used to calculate the corrosion reliability index of a given structure with fewer function calls. Finally, an aeronautical metal material is used to demonstrate the efficiency and precision of the proposed corrosion reliability method when the failure physical model considering the coupled effects of mechanical stresses and corrosion environment is adopted.
Millennial knowledge workers
Authors: Aydogmus Ceren 
Published: August 2019

PurposeThe purpose of this paper is to examine the potential effects of Millennial knowledge workers’ emotional intelligence (EI) on their subjective career success (SCS) through their protean career attitudes (PCAs) and psychological empowerment (PE).Design/methodology/approachSurvey methodology was used to collect data from 623 Millennial knowledge workers in 42 Turkish Information Technology companies. Participants answered the surveys at three different points within a 12-week period. Measures of EI, PCAs, PE and SCS were analyzed using structural equation modeling and the bootstrapping method.FindingsThe empirical results provide support for the author’s proposed model that positive relations between EI and Millennial knowledge workers’ SCS are mediated by their PCAs and PE.Research limitations/implicationsTo generalize the study findings, future research should be conducted for Millennial knowledge workers in different cultures and countries.Practical implicationsParticularly for Millennial knowledge workers, managers need to be aware of positive influence of EI on employees’ SCS and should consider implementing policies and procedures that recognize EI as a key ingredient for their SCS. Additionally, human resource professionals should aim to create an organizational culture around career development, in addition to career attitudes trainings, and provide career growth opportunities to retain Millennial talent. Finally, organizational development professionals should establish work environments that increase employee empowerment and thus improve SCS.Originality/valueThe findings advance the understanding of how Millennial knowledge workers’ EI can influence their SCS through focusing on PCAs and PE. The results underpin the self-determination theory, contextualist action theory of career development and job design theory.
Social justice leadership, instructional leadership, and the goals of schooling
Authors: Shaked Haim 
Published: August 2019

Purpose
School principals should see themselves as social justice leaders, who have the ability to allow all students to succeed, regardless of their characteristics and backgrounds. At the same time, school principals are also called upon to demonstrate instructional leadership, which emphasizes the teaching and learning aspects of school principalship. The purpose of this paper is to examine the relations between these two roles of today’s school principals.

Design/methodology/approach
To investigate the relations between social justice leadership and instructional leadership, this paper adds the question of the goal of schooling to the mix. After identifying possible goals of schooling, the paper conceptualizes social justice leadership and instructional leadership, respectively, while also examining their relations with schools’ major goals. Possible commonalities and contradictions between social justice leadership and instructional leadership are discussed.

Findings
The prevalent expectation that school leaders should give top priority to ongoing improvement of teaching quality and academic outcomes may be seen as reducing school leaders’ involvement in some aspects of social justice leadership, such as nurturing students’ active citizenship.

Research limitations/implications
This paper opens new research avenues. Based on the findings of this paper, the connection between principals’ perceptions regarding the goals of schooling and their leadership behaviors should be explored.

Practical implications
It seems advisable to discuss the interplay between social justice leadership and instructional leadership with prospective and current principals, as well as with other school stakeholders.

Originality/value
Insofar as the relations between social justice leadership and instructional leadership have not been explored so far, this paper narrows a gap in the available knowledge.
Broadening borders to build better schools
Authors: Carpenter Daniel , Munshower Paul 
Published: August 2019

PurposeThe purpose of this paper is to explore how rural teachers provided a PLC by leveraging virtual technologies to connect educators of like subject disciplines from several schools, foreign and domestic.Design/methodology/approachA phenomenological case study-based approach was leveraged to investigate established vPLCs at schools (Creswell, 2013; Stake, 2010). Qualitative data were collected from multiple sources to obtain rural teacher perceptions on the impact vPLCs had on their practice (Creswell, 2013).FindingsTeacher collaborative teams build relationships comparable to teams that met face to face as part of a similar PLC and PD experience. Participant reflections in this investigation showed that rural educators favored face-to-face meetings; however, vPLCs provided similar teacher experiences to that of the face-to-face PBL model. Results indicated that educators recognized virtual collaboration just as valuable a tool for enabling PLCs than face-to-face collaborations while still offering similarities to improved teacher practice.Research limitations/implicationsThe research was limited to teachers in rural settings in the USA (Texas) and in the Dominican Republic. The research was limited to teacher perceptions of change, and observed changes as part of their participation in a research-based virtual PLC model. The research was limited to the school setting over an academic year.Practical implicationsThe findings from this study have practical implications for rural teachers and school implementation of a professional learning community model.Originality/valueThe promise provided by this study is that vPLCs may provide opportunity for rural schools to provide a job-embedded professional development model (Croftet al., 2010) for otherwise isolated teachers (Barrettet al., 2015).
Pedagogical dilemmas among Bedouin-Palestinian peace educators in Israel
Authors: Litvak Hirsch Tal , Lazar Alon , Abu Hadubah Kamal 
Published: August 2019

Purpose
The purpose of this study is to learn how minority peace educators grapple with dilemmas related to their involvement in peace programs.

Design/methodology/approach
A total of 15 male teachers, members of the minority Bedouin community in Israel, all peace educators, provided their reactions to three dilemmas, addressing various facets of the strained relations of their community with the Jewish-Israeli majority, as influenced by the Israeli–Palestinian conflict.

Findings
The responses to these dilemmas suggest that when it comes to questions of the identity of these teachers as members of a marginalized community, their responses considerably diverge. This is not the case when it comes to their identity as peace educators.

Originality/value
This suggests that if the aim is to bring peace educators, members of minority groups in conflict zones, to harness their potential to bring about positive change, their peace activist identities must be strengthened.
Value creation through quality and innovation – a case study on Portugal
Authors: Santos Gilberto , Gomes Sergio , Braga Vitor , Braga Alexandra , Lima Vanda , Teixeira Paulo , Sá José Carlos 
Published: August 2019

Purpose
The purpose of this paper is to analyze the best way to create value in Portugal through quality and innovation and also to check what needs to be improved.

Design/methodology/approach
A questionnaire was applied to population of 152 companies, with the research and development (R&D) management certified by Portuguese Standard NP 4457. The final sample was 66 companies, which correspond to 45 percent of the population. Statistical analysis of the data collected was performed using IBM SPSS Statistical Software.

Findings
The authors highlighted the main reasons/motivations that led companies to implement the NP 4457, which were, among others, competitive advantage and creating value. The systematization of information and the generation and management of ideas were highlighted as the main advantages. The lack of methodologies for innovation management and knowledge management was the difficulty experienced in the implementation of NP 4457. Portugal needs to increase patent registration and it also needs to know how to take advantage of the investment made in R&D, in order to decrease the unit cost of knowledge. Portuguese engineering should be more about product design than production processes. The involvement of top management must be greater.

Originality/value
This investigation contributes to the innovation and quality body of knowledge, since it explores the complementarity between the two concepts as sources of value creation. This case study is one of the first Portuguese empirical research works about value creation through quality and innovation in Portugal. It also allows to know in detail the Portuguese business reality in terms of innovation management.
Performance investigation of a solar-driven ejector refrigeration cycle
Authors: Saleh B. , Aly Ayman A. , Alsehli M. , Bassuoni M.M. , Elfasakhany A. 
Published: August 2019

Purpose
This paper aims to investigate the performance and working fluids screening for an ejector refrigeration cycle (ERC) activated by solar energy. Several common and new hydrofluorocarbons, hydrocarbons, hydrofluoroolefins and hydrofluoroethers are proposed as refrigerants for the ERC to determine the most appropriate one.

Design/methodology/approach
The ejector performance is characterized by the ejector area ratio (EAR) and entrainment ratio (ω), while the cycle performance is described by the coefficient of performance (COP). The influences of many working parameters like the evaporator, condenser and generator temperatures on the ejector and cycle performances are investigated for all candidates as well.

Findings
The results indicate that the best ejector and cycle performances are attained with the highest critical temperature dry refrigerant, i.e. R601 under all studied working conditions. From the perspective of energy efficiency and environmental issues, R601 can be considered the most appropriate working fluid amongst all candidates. However, extra attention should be considered against its flammability. The maximum COP, the corresponding ω and the necessary EAR using R601 are 0.743, 1.02 and 15.5, respectively, with 25 ºC condenser temperature and the typical values for the rest operating conditions.

Originality/value
Many common and new hydrofluorocarbons, hydrocarbons, hydrofluoroolefins and hydrofluoroethers are suggested as working fluids for the ERC to determine the most appropriate one. The mixing process inside the ejector constant-area section is assumed constant-pressure process.