bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disparities in Global Authorship and Data Source in the Pediatric Blood and Cancer Journal 2011–2021: Realities and Strategies for Improvement
Authors: Burns Kathryn , Martiniuk Alexandra , Islam Md Irteja , Opoku Dominic Agyemang , Luo Yuanhui , Malahlela Dorcas , Pickard Anita , Sniderman Elizabeth , Challinor Julia 
Published: November 2024

ABSTRACTBackgroundResearch expands knowledge and improves outcomes. Research is needed in all settings, but most often occurs in high‐income countries (HIC) compared to low‐ and middle‐income countries (LMICs). Publication in scientific peer‐reviewed journals and authorship position are important for academic/clinical advancement. We explored the current state of global authorship and data source distribution for publications in the Pediatric Blood and Cancer (PBC) journal.ProcedureLMIC‐affiliated author inclusion and position in selected article categories of the PBC (2011–2021) were recorded. Articles with at least one LMIC‐affiliated author (first‐listed affiliation) and 5% of exclusively HIC‐authored articles were verified. Descriptive statistical analysis was performed.ResultsOf 4504 articles reviewed, 593 (13%) included at least one LMIC‐affiliated author (517/593 [87%] as first author and 488/593 [82%]) as senior author. In a subset of articles with LMIC‐sourced data, 148/675 (22%) included exclusively HIC authors. Within the LMIC‐sourced data subset, 81/675 (12%) articles were mixed HIC/LMIC affiliation and 446/675 (66%) were exclusively LMIC‐affiliated. The frequency of LMIC‐affiliated authors as first or senior author within HIC/LMIC‐affiliated collaborations was 31/81 (38%) and 9/81 (11%), respectively.ConclusionAs more than 80% of children live in LMICs and the WHO Global Initiative for Childhood Cancer is increasingly engaged across LMICs, all researchers/clinicians must justly be given an opportunity to conduct, write, publish, and be recognized for their research. PBC is uniquely poised to promote equitable publishing practices and opportunities for professional recognition by drawing on emerging best practices for equitable authorship, including potentially restructuring authorship guidelines and requirements.
Epoxy composites produced via sodium alginate‐mediated Ca crosslinking of MXene and boron nitride fillers with excellent thermal conductivity and electromagnetic interference shielding effectiveness
Authors: Lee Jaekyung , Lee Wondu , Kim Jihoon , Kim Munho , Kim Jooheon 
Published: November 2024

AbstractThis study investigates novel polymer composites for enhanced thermal conductivity and electromagnetic interference (EMI) shielding. By incorporating sodium alginate‐mediated Ca crosslinked MXene and boron nitride fillers into an epoxy matrix, the composites exhibit significantly improved thermal, electrical, and mechanical properties. Surface treatment enhanced filler dispersion and interfacial bonding by introducing hydroxyl groups, which improve compatibility between the fillers and the matrix, thereby reducing agglomeration and creating robust thermal and electrical conduction networks. Hot‐pressing method further increases composite density by eliminating internal voids and aligning the fillers more effectively, resulting in superior characteristics. The best performing hot‐pressed composite achieved a through‐plane thermal conductivity of 7.45 W/m K, excellent EMI shielding effectiveness of 58.3 dB, along with a tensile strength of 37.2 MPa and an elongation as high as 3.8%. These enhancements make the composites highly suitable for advanced electronic devices where efficient heat dissipation and EMI shielding are critical.Highlights
Surface treatment improves filler dispersion and compatibility.
High‐filler composites are fabricated by hot‐pressing method.
MX‐CA‐BN/EPH composites achieve 7.45 W/m K thermal conductivity.
Enhanced EMI shielding effectiveness of 58.3 dB.
The association between coronavirus disease 2019 vaccination during pregnancy and neonatal health outcomes
Authors: Woestenberg Petra J. , Maas Veronique Y. F. , Vissers Lieke C. M. , Oliveri Nadia M. B. , Kant Agnes C. , de Feijter Maud 
Published: November 2024

ABSTRACTImportancePregnant women have a higher risk of severe illness or complications due to a severe acute respiratory syndrome coronavirus 2 infection. To reduce these risks, pregnant women are advised to coronavirus disease 2019 (COVID‐19) vaccination. Continued monitoring of the safety of maternal COVID‐19 vaccination remains important.ObjectiveTo evaluate the association between maternal COVID‐19 vaccination and neonatal health.MethodsData from the Dutch Pregnancy Drug Register were used. In this prospective cohort study, pregnant women self‐reported COVID‐19 vaccination and neonatal health outcomes. We included women with a due date between January 15, 2021, and May 15, 2022, and a singleton live birth after at least 24 weeks gestation. Using log‐binomial regression analysis we studied the association between COVID‐19 vaccination during pregnancy and the health outcomes; small for gestational age (SGA), large for gestational age (LGA), and neonatal health problems. We corrected for potential confounders using inverse probability of treatment weighting.ResultsIn total, 3655 participants were included (92.1% COVID‐19 vaccinated during pregnancy). Of all participants, 8.9% reported SGA, 11.1% reported LGA, and 16.4% reported neonatal health problems. Maternal COVID‐19 vaccination was not statistically significantly associated with SGA (adjusted prevalence ratio [aPR]: 0.90; 95% confidence interval [CI]: 0.59–1.36), LGA (aPR: 1.07; 95% CI: 0.70–1.63), or neonatal health problems (aPR: 0.84; 95% CI: 0.63–1.11).InterpretationThis study indicates that COVID‐19 vaccination during pregnancy is not associated with self‐reported adverse neonatal health outcomes. These findings contribute to the growing body of evidence on the safety of COVID‐19 vaccination during pregnancy.
Quantitative pharmacology of dual‐targeted bicistronic CAR‐T‐cell therapy using multiscale mechanistic modeling
Authors: Su Mei‐Chi , Dey Agnish , Maddah Erfan , Mugundu Ganesh M. , Singh Aman P. 
Published: November 2024

AbstractDespite the initial success of single‐targeted chimeric‐antigen receptor (CAR) T‐cell therapy in hematological malignancies, its long‐term effectiveness is often hindered by antigen heterogeneity and escape. As a result, there is a growing interest in cell therapies targeting multiple antigens (≥2). However, the dose–exposure–response relationship and specific factors influencing the pharmacology of dual‐targeted CAR‐T‐cell therapy remain unclear. In this study, we have developed a multiscale cellular kinetic–pharmacodynamic (CK–PD) model using case studies from CD19/CD22 and GPRC5D/BCMA autologous CAR‐Ts. Initially, an in vitro tumor‐killing model characterized the impact of individual binder affinities and their contribution to overall potency across varying (1) effector: target (ET) ratios and (2) tumor‐associated antigen (TAA) expressing cell lines. Subsequently, an integrated CK–PD model was developed in pediatric acute lymphoblastic leukemia (ALL) patients, which accounted for CAR‐T‐cell product composition and relative antigen abundance in patients' tumor burden to characterize patient‐level multiphasic cellular kinetics using multiple bioanalytical assays (e.g., flow and qPCR‐based readouts). Global sensitivity analysis highlighted relative antigen expression, maximum killing rate constant, and CAR‐T expansion rate constant as major determinants for observed exposure of dual‐targeted CAR‐T‐cell therapy. This modeling framework could facilitate dose‐optimization and construct refinement for dual‐targeted bicistronic CAR‐T‐cell therapies, serving as a valuable tool for both forward and reverse translation in drug development.
Epoxymicheliolide Reduces Radiation‐Induced Senescence and Extracellular Matrix Formation by Disrupting NF‐κB and TGF‐β/SMAD Pathways in Lung Cancer
Authors: Zhou Heng , Chen Yong , Jiang Ningzu , Ren Yanxian , Zhuang Jiayuan , Ren Yue , Shen Lin , Li Chenghao 
Published: November 2024

ABSTRACTLung cancer is a major cause of cancer‐related mortality, and radiotherapy is often limited by tumor resistance and side effects. This study explores whether epoxymicheliolide (ECL), a compound from feverfew, can enhance radiotherapy efficacy in lung cancer. We tested ECL on A549 and PC‐9 lung cancer cell lines to evaluate its effect on x‐ray irradiation. We measured apoptosis, NF‐κB pathway inhibition, TGF‐β secretion reduction, and epithelial‐mesenchymal transition suppression. In vivo, C57BL/6 mice with lung tumors received ECL and radiotherapy. ECL enhanced the antiproliferative effects of x‐ray irradiation, induced apoptosis in senescent cells, inhibited the NF‐κB pathway, reduced TGF‐β levels, and suppressed epithelial‐mesenchymal transition. ECL also inhibited tumor growth and improved survival in mice. ECL is a promising adjunct to radiotherapy for lung cancer, improving treatment outcomes by targeting multiple tumor progression mechanisms. It offers potential for enhanced management of lung cancer.
Successful treatment of a persistent air leak with an endobronchial valve in a 17‐year‐old patient with necrotizing pneumonia
Authors: Janssen Nina M. , Posthuma Rein , Kienhorst Sophie , Bannier Michiel A. G. E. , Lalji Ulrich C. , Franssen Frits M. E. , Sprooten Roy T. M. 
Published: November 2024

AbstractPleural empyema is a severe condition associated with high morbidity and mortality. Treatment usually consists of pleural drainage with chest tube or surgery, in combination with antimicrobial treatment. Severe pneumonia can evolve in a necrotizing pneumonia, given a higher susceptibility to the occurrence of bronchopleural fistulas with persistent air leaks. This complicates recovery, and surgery may not always be the optimal treatment. We present a case involving a 17‐year‐old female patient who experienced a post‐operative persistent air leak due to necrotizing pneumonia after video‐assisted thoracic surgery decortication for empyema, which was successfully treated using an endobronchial valve. After 6 months the valve was removed without complications. Follow‐up imaging and lung function revealed a limited area of atelectasis and minimal pleural thickening with normal lung volumes.
Synthesis, In Vivo, ADME Determination, and Molecular Docking Studies of 1,3,4‐Oxadiazoles Containing Pyridine and Piperazine Moieties as New Diuretic Agents
Authors: Faizan Md , Kumar Rajnish , Mazumder Avijit , Salahuddin  , Tyagi Pankaj Kumar , Ataya Farid S. , Khanna Virat , Sobti Rajeev , Pavani A. Sai , Bushi Ganesh , Gaidhane Shilpa 
Published: November 2024

AbstractA series of 1‐(piperazin‐1‐yl)‐2‐((5‐(pyridin‐4‐yl)‐1,3,4‐oxadiazol‐2‐yl)thio)ethan‐1‐one derivatives (9a–l) were prepared using a multistep reaction between 2‐chloro‐1‐(piperazin‐1yl)ethan‐1‐one derivatives (4a–l) and 5‐(pyridine‐4‐yl)‐1,3,4‐oxadiazole‐2‐thiol (8) and studied their diuretic potential by following established in vivo and in silico protocols. The data obtained from the experimental rat animal model in vivo diuretic studies indicated that synthesized derivatives 9d, 9e, 9g, 9i, and 9j possess excellent diuretic potential. The results obtained from in vivo study were also reinforced by the data of in silico studies performed using AutoDock (1.5.7) software. The molecular docking involved interactions of synthesized molecules with two target proteins, that is, human carbonic anhydrase II protein (hCA‐II, PDB ID: 3HS4) and human NKCCl K289NA492E protein (NKCCl, PDB ID: 7S1Y). The ADME properties of the synthesized molecules have also been determined using pkCSM software that established that the synthesized molecules are good candidates for oral absorption. All the data of in vivo and in silico studies synergized the results that state that the diuretic activity of all synthesized compounds is greater than that of the standard drug (furosemide), whereas compounds 9d, 9e, 9g, 9i, and 9j show excellent activity with values of 1.32, 1.33, 1.35, 1.39, and 1.35, respectively.
β‐Cyclodextrin‐SO3H as a Supramolecular Catalyst for Efficient Greener Synthesis of Substituted Bis(6‐aminouracil‐5‐yl)methanes in Water
Authors: Gosavi Swati D. , Kale Arun D. , Dalal Dipak S. 
Published: November 2024

AbstractA simple, straightforward, and highly efficient greener approach for synthesizing bis(6‐aminouracil‐5‐yl)methane derivatives was developed by employing β‐cyclodextrin‐SO3H as supramolecular catalyst in water at 100 °C. A total of 16 bis(6‐aminouracil‐5‐yl)methanes were synthesized via a one‐pot reaction between substituted aromatic aldehydes, 6‐amino‐1,3‐dimethyluracil, and 10% β‐cyclodextrin‐SO3H in water with 84%–92% yield within 20–120 min. The salient features of this protocol included water as green solvent, β‐cyclodextrin‐SO3H as recyclable supramolecular catalyst, mild reaction conditions, easy isolation of pure products, and good to excellent yields.
Realizing the Electrode Engineering Significance Through Porous Organic Framework Materials for High‐Capacity Aqueous Zn–Alkaline Battery
Authors: Jesudass Sebastian Cyril , Surendran Subramani , Lim Yoongu , Jo Minjun , Janani Gnanaprakasam , Choi Heechae , Kwon Gibum , Jin Kyoungsuk , Park Hyunjung , Kim Tae‐Hoon , Sim Uk 
Published: November 2024

AbstractEnergy storage technologies are eminently developed to address renewable energy utilization efficiently. Porous framework materials possess high surface area and pore volume, allowing for efficient ion transportation and storage. Their unique structure facilitates fast electron transfer, leading to improved battery kinetics. Porous organic framework materials like metal–organic (MOF) and covalent organic (COF) frameworks have immense potential in enhancing the charge/discharge performances of aqueous Zn–alkaline batteries. Organic frameworks and their derivatives can be modified feasibly to exhibit significant chemical stability, enabling them to tolerate the harsh battery environment. Zn–alkaline batteries can achieve enhanced energy density, longer lifespan, and improved rechargeability by incorporating MOFs and COFs, such as electrodes, separators, or electrolyte additives, into the battery architecture. The present review highlights the significant electrode design strategies based on porous framework materials for aqueous Zn–alkaline batteries, such as Zn–Ni, Zn–Mn, Zn–air, and Zn–N2/NO3 batteries. Besides, the discussion on the issues faced by the Zn anode and the essential anode design strategies to solve the issues are also included.
Analysis of human wildlife conflict call volume variation during the COVID‐19 global pandemic protective measures in Florida
Authors: Diaz Rachael , Shea Colin , Latour Rhonda , Johnston Jayne 
Published: November 2024

AbstractFlorida Fish and Wildlife Conservation Commission's Wildlife Assistance Biologists (WABs) receive calls from the public experiencing a wildlife conflict and provide guidance on how to coexist with native wildlife. This analysis considered how the number of calls and nature of calls received by WABs were impacted by COVID‐19 pandemic protective measures in Florida. Total calls to WABs decreased during COVID‐19 protective measures but did not vary significantly from the previous year. There was a significant decrease in the average weekly number of “Sick/Injured” wildlife calls and “Property Damage” calls when protective measures were in place. This analysis provides insight into how widespread changes in human mobility may impact reports of human‐wildlife conflict.
Development of Self‐Adjuvants in mRNA Vaccine and Its Application in Disease Prevention and Treatment
Authors: Yu Huaibin , Lu Yafang , Miao Zhuorong , Zha Zhengbao , Liu Shaoqin 
Published: November 2024

ABSTRACTAdjuvants augment the immunogenicity of vaccines when co‐administered with messenger RNA (mRNA) antigens. In recent years, nanotechnology and nanoscience have seen significant growth, resulting in the discovery of synthetic small molecule compounds, natural extracts, and nanomaterials with self‐adjuvant properties for nano delivery. The materials exhibit robust immune activity and efficiently activate various innate immune signaling pathways. Moreover, they possess a comparatively simple chemical composition in contrast to conventional adjuvants. This significantly streamlines the manufacturing process of vaccine formulations. Therefore, these self‐adjuvant materials theoretically improve the reproducibility of adjuvant production and quality control. Herein, this review summarizes the current research and development progress of mRNA adjuvants, with a specific focus on various types of mRNA adjuvants, notably self‐adjuvant nanomaterials. It discusses the current research status on a range of diseases and investigates the potential development of mRNA vaccine adjuvants.
Application of IPv6 in the Intelligent Sensing Technology of Flood and Waterlogging Prevention
Authors: Chen Weichang , Wei Sangang , Zhang Bing , Zhang Binpei 
Published: November 2024

AbstractDue to the special landform, complex river system and rapid development of urban agglomerations in the Guangdong-Hong Kong-Macao Greater Bay Area, the task of flood and waterlogging prevention in the Greater Bay Area is heavy and its responsibility is important. In order to effectively improve the effectiveness of flood and waterlogging prevention, this paper analyzes current problems facing flood and waterlogging prevention in the Greater Bay Area, and proposes building an intelligent sensing IoT network of Flood and Waterlogging Prevention based on IPv6 and IoT technology, making the flood warning’s response time be reduced from 60 ms to less than 30 ms, to provide more efficient, more precise and more secure network support and data protection for flood and waterlogging prevention.
Seismic Response Analysis of Subsea Tunnels Under the Influence of Overlying Seawater
Authors: Huang Weizhen , He Cong , Xu Guoyuan 
Published: November 2024

AbstractThe safety of subsea tunnels during earthquakes is a crucial factor in the design process. It is appropriate to consider the impact of the seawater above when assessing the seismic resistance of a subsea tunnel. In this paper, finite element models of the seawater-seabed-tunnel structure system are established using ABAQUS software to investigate the fluid–structure interaction and plastic damage of the lining. The seismic response and damage characteristics of the subsea tunnel are compared at various seawater depths. The study found that the overlying seawater inhibits the vertical movement of the seabed surface, but has minimal effect on the horizontal movement. With the increase in seawater depth, the stress on the tunnel structure will noticeably increase, with the spandrel and arch foot becoming the weak points in seismic design. Overlying seawater will increase the dissipation energy of the tunnel system, leading to tunnel damage. When the seawater depth exceeds 20 m, the tunnel system’s dissipation energy at varying depths of seawater will significantly increase.
Study on Joint Regulation of Runoff and Sediment of Water Supply Reservoirs in Sediment-Laden River Dongzhuang Reservoir of Jinghe River
Authors: Chen Cuixia , Wang Haixia , Luo Qiushi , Wen Zhichao , Liu Junxiu , Wang Tiange 
Published: November 2024

AbstractThere is independence and integration between water supply and sediment reduction in sediment-laden river reservoirs. How to maintain effective storage capacity and meet water supply requirements for a long time is one of the problems to be solved in the efficient operation of sediment-laden river reservoirs. In this paper, Dongzhuang Reservoir of Jinghe River is taken as the research object. Through the analysis of measured data and mathematical model calculation, the measured hydrological sediment and cross-section erosion and deposition in the lower reaches of Jinghe River and Weihe River are analyzed. The reservoir sediment discharge flow index which is beneficial to reduce the sediment deposition in the lower reaches of Weihe River and maintain the effective reservoir capacity for a long time is studied, and the joint regulation mode of reservoir runoff and sediment is put forward. The results show that the sediment regulation of Dongzhuang Reservoir during the sediment retention period is mainly to reduce the deposition of the lower reaches of the Weihe River, and the sediment regulation during the normal operation period of the reservoir is mainly to maintain the effective storage capacity of the reservoir for a long time. The joint regulation of the Dongzhuang Reservoir and the surrounding four storage reservoirs, such as the Ganhe Reservoir, the Xijiao Reservoir, the Longtan Reservoir, and the Helan Reservoir, can reduce the deposition of the lower reaches of the Weihe River by 11 million tons per year, increase the guarantee rate of agricultural irrigation from 30 to 50%, and increase the guarantee rate of industrial water supply from 57 to 95%. And the outflow of the reservoir meets the requirements of the ecological base flow of the river. The research results provide technical support for the optimal operation of reservoirs in sediment-laden rivers.
The Influence of Rain-Type on the Seepage and Stability of Purple Silty Cohesive Soil Slope
Authors: Jiang Ou , Yang Shiyi , Yan Xuancheng , Yang Can , Liu Tong 
Published: November 2024

AbstractTo study the variation law of internal seepage and stability of purple silty cohesive unsaturated soil slope under different rain patterns, we use GeoStudio to calculate and analyze the changes of pore water pressure and safety factor of the slope after undergoing three rain patterns, namely, front peak pattern, back peak pattern and step pattern, under the action of moderate rain, heavy rain and rainstorm. Research has found that under the same conditions, it takes the longest time for the pore water pressure under the back peak type to reach stability, and the slope safety factor decreases the most. Therefore, it is necessary to strengthen the management of slope stability protection after rainfall in the back peak type.
Hydraulic Calculation and Analysis of Head Cover Drainage System of Hydropower Station Based on PIPENET
Authors: Long Zhe , Lu Xing , Zheng Yingxia , Shu Lingfeng , Su Wenbo 
Published: November 2024

AbstractIn order to analyze the influence of the siphon effect in the pipeline on the actual operation of the head cover drainage system in different working conditions of a hydropower station, a reasonable and effective siphon failure device is set up. Based on PIPENET, the fluid calculation and analysis software of pipe network, this paper aims at the overall modeling of the head cover drainage system of the hydropower station, and then conducts hydraulic calculation and analysis on it, and studies the design scheme of damage siphon effect, which provides strong support for the optimal design of the head cover drainage system.
Observation of Navigational Hydraulic Characteristics in the Downstream Entrance Area
Authors: Wang Xin , Zhang Shouyuan 
Published: November 2024

AbstractStrong transverse flows and fluctuations often occur in the downstream approach channel and entrance area during flood discharge at high dam hubs. This study takes a power station as a research sample. Flow velocities, transverse flow intensities, fluctuation characteristics and ship navigation status are analyzed and studied through field observations. The results show that during flood discharge the entrance area experiences transverse short-wave fluctuations and significant transverse currents. The oscillation of hydraulic jumps is the direct factor causing fluctuations in the downstream entrance area. The fluctuation amplitude of the center and edge of the entrance area was generally large, and the fluctuation spread to the approach channel and continuous attenuation. The main fluctuation attenuation occurs at the transition from the broad riverway to the downstream restricted approach channel. As the flood discharge increases, the lateral rolling of the ships becomes more pronounced. The change in power station discharge has a relatively small effect on the ships’ heeling and trim.