bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anisotropic Mechanical Responses of Poly(Ethylene Oxide)‐Based Lithium Ions Containing Solid Polymer Electrolytes
Authors: Patra Sudeshna , Yeddala Munaiah , Daga Piyush , Narayanan Tharangattu N. 
Published: October 2019

AbstractDevelopment of mechanically deformable solid state devices is receiving tremendous attention, and high ionic conductivity solid polymer electrolytes (SPEs) are highly sought after for their development. The process history‐induced polymer alignment anisotropy can lead to anisotropic conductivity to the SPEs. Here, a Li ion SPE membrane developed using poly(ethylene oxide) (PEO) and LiClO4 is demonstrated for its microstructure variations while applying external stress and the corresponding variations in the ionic conductivity are also calculated. The microstructural evolution shows that larger strain values induce large dislocations in the crystallites of PEO leading to the formation of larger amorphous regions which soften the matrix. The anisotropic mechanical responses are observed while applying cyclic strain to thicker SPEs, where the compressive measurements show softening of the matrix while tensile measurements harden the matrix. The ionic conductivities of the softened matrix are found to be enhanced while those of toughened matrix are found to be decreased. This detailed mechanical analysis along with the in situ ionic conductivity studies of PEO‐based Li ion SPE show that along with the thermal history of the polymers, process history and the anisotropic mechanical responses of the polymers also need to be considered while developing SPEs for flexible devices.
Comparing measures of persuasion knowledge adapted for young children
Authors: Wang Shasha , Mizerski Dick 
Published: October 2019

AbstractYoung children under 8 years old are viewed as especially vulnerable to marketing communications because they do not have sufficient knowledge about the purpose of persuasive advertising messages, also known as children's persuasion knowledge (CPK). However, a review of 25 studies that have tested CPK effects, on primarily older children, finds inconsistent or no support for CPK. The lack of support depends on the effect studied, and a measurement challenge because of young children's limited capabilities in reading and responding to questions from interviewers. Thirteen measures of CPK have been tested but not compared for CPK effects. These measures were simplified to nonverbal options for young children and tested on a sample of 4‐ to 7‐year‐old North East Chinese children (n = 233). These measures were each tested in relation to the children's age (positive), their skepticism toward advertising (positive), their disbelief of false claims in a TV commercial (TVC) (positive) and their affect toward the TVC (negative). Only two measures of CPK show any expected associated responses with “knowing the source” of advertisements the best measure. Perceived marketer intentions had no expected associations, nor did the age of the child. The implications of these findings are discussed in terms of theory, measurement, and applications for marketers and public policy.
Incorporating bis‐benzimidazole into polyimide chains for effectively improving thermal resistance and dimensional stability
Authors: Lian Meng , Zheng Feng , Wu Qi , Lu Xuemin , Lu Qinghua 
Published: October 2019

AbstractHeteroaromatic 6,6′‐bis[2‐(4‐aminobenzene)benzimidazole] and its corresponding copolyimides were synthesized to produce high temperature resistant polyimides (PIs). Due to the rigidity and aromaticity of heterocyclic bis‐benzimidazole, and the increased hydrogen bonding interactions, these PIs were found to have a high glass transition temperature (Tg) over 457 °C, which also guarantees a better dimensional stability with a coefficient of thermal expansion (CTE) lower than 10 ppm K−1in a wider temperature range of 50–400 °C. In addition, the PIs exhibit excellent thermal stability (5% weight loss temperature higher than 559 °C) along with outstanding mechanical properties. This study demonstrates the viability to access PIs with ultrahighTgand low CTE in a wider range of temperature by the incorporation of bis‐benzimidazole moieties. © 2019 Society of Chemical Industry
Simultaneously achieving high strength, thermal resistance and high self‐healing efficiency for polyacrylate coating by constructing a Diels–Alder reversible covalent structure with multi‐maleimide terminated hyperbranched polysiloxane
Authors: Li Danyi , Zhang Youhao , Yuan Li , Liang Guozheng , Gu Aijuan 
Published: October 2019

AbstractIt is difficult for the self‐healing polyacrylate coatings reported so far to simultaneously achieve high mechanical strength and high self‐healing efficiency within a short healing time. Herein, derived from multi‐maleimide terminated hyperbranched polysiloxane, linear polyacrylate with furan‐containing side chain and polydopamine particles (photothermal conversion agent), a new kind of polyacrylate coating (HPA) with a strong and flexible crosslinking network was developed, which simultaneously shows high mechanical strength and high self‐healing efficiency within a short time. With 0.3 wt% polydopamine particles in HPA, the resulting coating (HPA3) has the highest toughness (2.63 ± 0.10 MPa) with 12.9 ± 0.7 MPa tensile strength and 23.9% ± 1.6% elongation at break; in addition, the self‐healing efficiency of HPA3 is over 87.6% after only 2.5 min of near‐infrared laser irradiation, overcoming intractable problems in developing self‐healing polyacrylate coatings. A study of the mechanism behind these outstanding performances of the HPA system reveals that the reversible covalent crosslinking formed by multi‐maleimide terminated hyperbranched polysiloxane is the necessary and crucial factor for simultaneously achieving high mechanical strength and high self‐healing efficiency in a short time. © 2019 Society of Chemical Industry
Increasing school personnel's self‐efficacy, knowledge, and response regarding nonsuicidal self‐injury in youth
Authors: Glennon Sara D. , Viola Shannon B. , Blakely Alane O. 
Published: October 2019

AbstractRates of students engaging in nonsuicidal self‐injury (NSSI) are rising and additional supports in the schools are needed (Nock, 2010, Ann Rev Clin Psychol, 6, 339–363; Stargell et al., 2017, Prof Sch Couns, 21, 37‐46). School psychologists, school counselors, and school nurses are key personnel in responding to self‐injurious behaviors within the school setting. The results of a practice‐based research project are described, in which school psychologists, school counselors, and school nurses participated in training to increase their self‐efficacy, knowledge, and response in regard to NSSI. The training provided information regarding best practice in responding to NSSI in youth (Hasking et al., 2016, Sch Psychol Int, 37(6), 644–663; Kanan et al., 2008, Sch Psychol Forum: Res Prac, 2, 67–79; Walsh & Muehlenkamp, 2013, Sch Psychol Forum: Res Prac, 7, 161–171). This exploratory study indicated that training positively impacted participants' perceived self‐efficacy and knowledge with respect to responding to youth who engage in NSSI. Handouts and resources for school‐based staff are included. Limitations and future directions are discussed.
Pharmmaker: Pharmacophore modeling and hit identification based on druggability simulations
Authors: Lee Ji Young , Krieger James M. , Li Hongchun , Bahar Ivet 
Published: October 2019

AbstractRecent years have seen progress in druggability simulations, that is, molecular dynamics simulations of target proteins in solutions containing drug‐like probe molecules to characterize their drug‐binding abilities, if any. An important consecutive step is to analyze the trajectories to construct pharmacophore models (PMs) to use for virtual screening of libraries of small molecules. While considerable success has been observed in this type of computer‐aided drug discovery, a systematic tool encompassing multiple steps from druggability simulations to pharmacophore modeling, to identifying hits by virtual screening of libraries of compounds, has been lacking. We address this need here by developing a new tool, Pharmmaker, building on the DruGUI module of our ProDy application programming interface. Pharmmaker is composed of a suite of steps: (Step 1) identification of high affinity residues for each probe molecule type; (Step 2) selecting high affinity residues and hot spots in the vicinity of sites identified by DruGUI; (Step 3) ranking of the interactions between high affinity residues and specific probes; (Step 4) obtaining probe binding poses and corresponding protein conformations by collecting top‐ranked snapshots; and (Step 5) using those snapshots for constructing PMs. The PMs are then used as filters for identifying hits in structure‐based virtual screening. Pharmmaker, accessible online at http://prody.csb.pitt.edu/pharmmaker, can be used in conjunction with other tools available in ProDy.
Human serum albumin presents isoform variants with altered neonatal Fc receptor interactions
Authors: Leblanc Yann , Berger Marie , Seifert Alexander , Bihoreau Nicolas , Chevreux Guillaume 
Published: October 2019

AbstractHuman serum albumin (HSA) is the most abundant protein in plasma and presents the particularity, with IgG, to have an extraordinary long serum half‐life conferred by its interaction with the neonatal Fc receptor (FcRn). If the impact of IgG post‐translational modifications (PTMs) on FcRn binding is well documented, it is far less reported for HSA despite numerous PTMs occurring on the protein in plasma. HSA is susceptible to numerous degradation reactions in plasma, because of aging, oxidative stress or liver and pancreas related pathologies. In the present study, we combined FcRn affinity chromatography and mass spectrometry to investigate the impact of HSA PTMs upon FcRn binding. This methodology presents the advantage to distinguish the effect of a single modification from a plasma HSA preparation made of a mixture of different isoforms. Cys34 oxidation, Lys525 glycation, and Leu585 C‐terminal truncation, which are modifications related to several pathological conditions, were demonstrated to act negatively on HSA‐FcRn interaction. The HSA‐FcRn binding alteration generated by these modifications is consistent with their vicinity with the interaction interface of the two proteins. Results were discussed regarding altered half‐life of HSA observed in several disease states and pave the way toward new understandings of the hypoalbuminemia pathogenesis.Significance statementIn this study, we investigated the impact of several post‐translational modifications of HSA toward its ability to bind to the neonatal Fc receptor using in vitro affinity chromatography, mass spectrometry, and surface plasmon resonance. Cys34 oxidation, Lys525 glycation, and Leu585 C‐terminal truncation were demonstrated to decrease HSA‐FcRn binding. These modifications occurring in circulating HSA were discussed in relation to several pathologies as well as for the use of HSA as a therapeutic protein.
Clonal evaluation of early onset prostate cancer by expression profiling of ERG, SPINK1, ETV1, and ETV4 on whole‐mount radical prostatectomy tissue
Authors: Lu Zhichun , Williamson Sean R. , Carskadon Shannon , Arachchige Pavithra D. , Dhamdhere Gaury , Schultz Daniel S. , Stricker Hans , Peabody James O. , Jeong Wooju , Chitale Dhananjay A. , Bismar Tarek A. , Rogers Craig G. , Menon Mani , Gupta Nilesh S. , Palanisamy Nallasivam 
Published: October 2019

AbstractBackgroundExpression profiles of erythroblast transformation‐specific (ETS)‐related gene fusions and serine protease inhibitor Kazal‐type 1 (SPINK1) in early onset prostate cancer have not been thoroughly explored.MethodsWe retrieved 151 radical prostatectomy specimens from young men with prostate cancer (<55 years) and characterized the expression of ETS‐related gene (ERG), SPINK1, ETS Variant 1 (ETV1), and ETV4 by dual immunohistochemistry and dual RNA in situ hybridization. Age, race, family history, preoperative prostate‐specific antigen, biochemical recurrence, and pathological variables using whole‐mount radical prostatectomy tissue were collected.ResultsA total of 313 tumor nodules from 151 men including 68 (45%) Caucasians and 61 (40%) African Americans were included in the analysis. Positive family history of prostate cancer was seen in 65 (43%) patients. Preoperative prostate‐specific antigen ranged from 0.3 to 52.7 ng/mL (mean = 7.04). The follow‐up period ranged from 1 to 123.7 months (mean = 30.3). Biochemical recurrence was encountered in 8 of 151 (5%). ERG overexpression was observed in 85 of 151 (56%) cases, followed by SPINK1 in 61 of 151 (40%), ETV1 in 9 of 149 (6%), and ETV4 in 4 of 141 (3%). There were 25 of 151 (17%) cases showing both ERG and SPINK1 overexpression within different regions of either the same tumor focus or different foci. Higher frequency of ERG overexpression was seen in younger patients (≤45 years old; 76% vs 49%, P = .002), Caucasian men (71% vs 41% P = .0007), organ‐confined tumors (64% vs 33%, P = .0008), and tumors of Gleason Grade groups 1 and 2 (62% vs 26%, P = .009). SPINK1 overexpression was more in African American men (68% vs 26%, P = .00008), in tumors with high tumor volume (>20%) and with anterior located tumors. ETV1 and ETV4 demonstrated rare overexpression in these tumors, particularly in the higher‐grade tumors.ConclusionThis study expands the knowledge of the clonal evolution of multifocal cancer in young patients and support differences in relation to racial background and genetics of prostate cancer.
Insecticide resistance and fitness cost in Bemisia tabaci (Hemiptera: Aleyrodidae) invasive and resident species in La Réunion Island
Authors: Taquet Alizée , Delatte Hélène , Barrès Benoit , Simiand Christophe , Grondin Martial , Jourdan‐Pineau Hélène 
Published: October 2019

AbstractBACKGROUNDGlobal and intensive use of insecticides has led to the emergence and rapid evolution of resistance in the major pest Bemisia tabaci (Gennadius). In La Réunion, an island of the South West Indian Ocean, three whitefly species coexist, two of which are predominant, the indigenous Indian Ocean (IO) and the invasive Middle East Asia Minor 1 (MEAM1) species. To assess the resistance level of both of these species to acetamiprid and pymetrozine, whitefly populations were sampled at 15 collection sites located all over the island in agroecosystems and natural areas, and tested using leaf‐dip bioassays. We also investigated the potential cost of resistance to acetamiprid by measuring six fitness‐related traits for MEAM1 populations that displayed different resistance levels.RESULTSIO was mainly found in natural areas and was susceptible to both acetamiprid and pymetrozine. MEAM1 populations displayed evidence of high resistance to pymetrozine, whereas resistance to acetamiprid was more variable. No fitness‐related costs were associated with this resistance in MEAM1 populations.CONCLUSIONThis is the first assessment of the susceptibility to insecticides for B. tabaci IO species. For the time being, no resistance to the tested insecticides has evolved in this species despite (i) its presence in agroecosystems and their surroundings, and (ii) its close proximity to, and possible hybridization with, the MEAM1 species. In contrast, with continuous selection pressure of insecticide treatments and in the absence of fitness cost to resistance, the invasive exotic species MEAM1 will continue to threaten agriculture in La Réunion. © 2019 Society of Chemical Industry
Who can ride along? Discrimination in a German carpooling market
Authors: Carol Sarah , Eich Daniel , Keller Michèle , Steiner Friederike , Storz Katharina 
Published: October 2019

AbstractAlthough numerous studies have focused on ethnic discrimination in the labour and housing market, carpooling has barely been covered. Yet carpooling is indispensable for many minorities because they face severe economic inequalities. In order to test for ethnic discrimination in the carpooling market, we conducted a correspondence test. We sent out requests from four fictitious user profiles to drivers listed on one of Germany's carpooling websites. All users were aged mid‐20s: two males and two females. One man and one woman had German names, the second set had Turkish names. In total, we collected 952 observations. Our field experiment reveals substantial discrimination by ethnicity and gender. Whereas women with German names are least likely to experience discrimination, men with Turkish names are the most likely to be discriminated against. At first sight, counterintuitively but in line with ethnic competition theory, users with Turkish names are not significantly more discriminated against by drivers on routes in East Germany where xenophobia is more prevalent compared with West Germany.
P‐13.13: The Technology of Narrow Border in Mobile Display
Authors: Ren Ruihuan , Zong Jiwen , Lee Wonkyu , Zhao Haiting , Chen Hao 
Published: October 2019

Thanks to new display technology development, mobile phone has been evolving from early analog phone to current smart phone. Most noticeable evidences include display evolution from digital to liquid crystal (LCD), and to more recent active‐matrix organic light‐emitting diode (AMOLED), color advancement from monochromic to full‐color, and display panel size from small‐screen to large‐screen. Besides, full‐screen has also become a new trend in mobile phone market since 2017. To meet the full‐screen display and/or to achieve the high screen‐to‐body ratio, display panel makers have come out a variety of screen design, notch, dew‐drop, hole‐punch, etc. Equally important, narrow border is another key technical requirement that will help increase the screen‐to‐body ratio, ultimately, enhancing visual experience. Technically, screen‐to‐body ratio of 90% or higher can be considered as a full‐screen. In order to meet this full‐screen display, it is necessary to reduce the bottom‐border from 4 mm to 1 mm, and leftand right‐borders from 1.2 mm to 0.5 mm, simultaneously. However, narrow border should be compatible with ESD, De‐mux circuits. This would require a width of about 1 mm in the FANOUT area. In addition, since the upper/left/right‐borders are only 0.5 mm or narrower, frit sealing may have only about 300 um in width, putting panel reliability in a great risk.In this paper, we will describe our technology route that not only can meet narrow border specification in the AMOLED display, but also can maintain the panel stability.
Design and Synthesis of 3‐(N‐Substituted)aminocoumarins as Anticancer Agents from 3‐Bromopeuruthenicin
Authors: Lipeeva Alla V. , Zakharov Danila O. , Gatilov Yurii V. , Pokrovskii Mikhail A. , Pokrovskii Andrey G. , Shults Elvira E. 
Published: October 2019

AbstractA convenient protocol for the rapid and efficient synthesis of 3‐bromopeuruthenicin 2 from plant coumarin peuruthenicin 1 is described. Coumarin 2 have been successfully reacted with N‐methylpiperazine, or 5‐aminoisoquinoline under reflux in chloroform with the formation of 3‐(N‐substituted)aminoumbelliferons. The easiness of formation of the mentioned compounds can be explained by occurring of the tautomerization processes in 3‐bromo‐7‐hydroxycoumarin 2 in the reaction conditions. For obtaining high yields of 3‐(arylamino)coumarins in the reaction of 3‐bromocoumarin 2 with substituted anilines the palladium‐catalyzed C–N coupling reaction was studied. The reaction proceeded cleanly in the presence of the Pd(OAc)2‐Xantphos catalytic system with the formation of the corresponding coupling products. The Suzuki cross‐coupling reaction of 3‐(3‐bromophenylamino)coumarin 8 f with aryl‐ and (hetaryl)boronic acids 11,13 and 14 using PdCl2(dppf) as the catalyst provided the formation of 3‐(N‐(aryl‐hetaryl))aminocoumarins 12, 15 and 16 in good yields. The cytotoxicity of new umbelliferone derivatives was evaluated against human cancer cells using the conventional MTT assays. The data revealed that compounds 12, 15 and 16 possessed most promising cytotoxic potential; aminocoumarins 12 and 16 shown selectivity toward the breast cancer cells MCF‐7. The cytotoxicity of 3‐(N‐substituted)aminocoumarins 12 and 16 on this cell lines was comparable to those of standard drug Doxorubicin.
Properties of Carbon Xerogels Supported Cobalt‐Based Catalysts and Their Performance in CO Hydrogenation Reaction
Authors: Han Yaoyao , Jin Yan , Hong Jingping , Jin Shiwei , Zhang Yuhua , Li Jinlin 
Published: October 2019

AbstractCarbon xerogels (C−X), which synthesized by a convenient method with moderate porous texture and high surface area, was used as potential support for cobalt‐based catalysts, and the catalytic performance was studied by CO hydrogenation. The use of activated carbon (AC) and carbon nanotubes (CNTs) as supports was also investigated for comparison. The catalysts were prepared by incipient wetness impregnation method, and adjustment of cobalt dispersion on Co/C−X was achieved by variation of the decomposition approaches of cobalt nitrate. Characterization and CO hydrogenation results showed that C−X is a good candidate as catalyst support, it could homogeneously disperse both big cobalt particles and small ones. And the supported Co/C−X catalysts had either higher catalytic activity or better reaction stability, in comparison with CNTs and AC supported counterparts. Glow discharge plasma assisted decomposition of cobalt nitrate led to the formation of much smaller cobalt particles, and due to the inert properties of carbon materials, the Co/C−X‐P catalyst showed both higher cobalt dispersion and cobalt reducibility than the calcined counterpart, and thus presented a much higher CO hydrogenation activity with good reaction stability as well.
ZnCl2/Urea Eutectic Solvent as Stable Carbonylation Source for Benign Synthesis of 2–Benzimidazolones and 2–Imidazolones: An Effective Strategy for Preventing NH3 Gas Evolution
Authors: Aghapoor Kioumars , Mohsenzadeh Farshid , Darabi Hossein Reza , Sayahi Hani , Jalali Mohammad Reza 
Published: October 2019

AbstractThe synthesis of 2‐benzimidazolone and 2‐imidazolone derivatives from urea as an inexpensive widely available carbonyl source is usually performed in high boiling organic solvents accompanied by ammonia evolution, due to urea decomposition. In this paper, a sustainable method has been introduced for the synthesis of these N,N‐heterocycles by employing zinc chloride:urea (1 : 3.5) type IV eutectic mixture under mild reaction conditions. No urea was used directly in the reaction owing to the fact that the eutectic mixture (containing urea itself) suffice to provide the carbonylation source. This new concept allowed the smooth conversion of a range of arene‐1,2‐diamines and benzoins to the corresponding N,N‐heterocycle in efficient yields. The remarkable advantage of this green protocol over other conventional heating procedures is that all reactions are conducted under open‐vessel conditions due to the absorption of the evolved ammonia by the eutectic mixture during the reaction process. (© WILEY‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)