bluuebunny/crossref_metadata_2025_split huggingface dataset:
CT-707 Overcomes Resistance of Crizotinib through Activating PDPK1- AKT1 Pathway by Targeting FAK
Authors: Liang Caixia , Zhang Ningning , Tan Qiaoyun , Liu Shuxia , Luo Rongrong , Wang Yanrong , Shi Yuankai , Han Xiaohong 
Published: November 2018

Background:
Crizotinib established the position of anaplastic lymphoma kinase-tyrosine
kinase inhibitors (ALK-TKI) in the treatment of non-small cell lung cancer (NSCLC) while the therapy-
resistance hindered those patients from benefitting continuously from the treatment. CT-707 is
an inhibitor of ALK/focal adhesion kinase (FAK) and IGFR-1. H2228CR (crizotinib resistance, CR)
and H3122CR NSCLC cell lines were generated from the parental cell line H2228 (EML4-ALK,
E6a/b:A20, variant 3) and H3122(EML4-ALK, E13:A20, variant 1), respectively.

Methods:
We investigated the antitumor effects CT-707 exerted against H3122CR in vitro /vivo.

Results:
Importantly, our study provided evidence that CT-707 overcomes resistance to crizotinib
through activating PDPK1-AKT1 pathway by targeting FAK. Meanwhile, by using an in-vivo
H3122CR xenograft model, we found CT-707 inhibited tumor growth significantly without obvious
side effects.

Conclusion:
These findings indicate that CT-707 may be a promising therapeutic agent against crizotinib-
resistance in NSCLC.
Prevalence of Thyroid Diseases in an Occupationally Radiation Exposed Group: A Cross-Sectional Study in a University Hospital of Southern Italy
Authors: Vimercati Luigi , De Maria Luigi , Mansi Francesca , Caputi Antonio , Ferri Giovanni M. , Luisi Vito , Lovreglio Piero , Cannone Enza S.S. , Lorusso Pietro , Gatti Maria F. , Massagli Chiara R.S. , Triggiani Vincenzo 
Published: November 2018

Background:
Thyroid diseases occur more frequently in people exposed to ionizing radiation,
but the relationship between occupational exposure to ionizing radiation and thyroid pathologies
still remains unclear.

Objective:
To evaluate the prevalence of thyroid diseases in healthcare workers exposed to low-level
ionizing radiation compared with a control group working at the University Hospital of Bari, Southern
Italy, and living in the same geographical area, characterized by mild iodine deficiency.

Methods:
We ran a cross-sectional study to investigate whether healthcare workers exposed to ionizing
radiation had a higher prevalence of thyroid diseases. Four hundred and forty-four exposed healthcare
workers (241 more exposed, or “A Category”, and 203 less exposed, or “B Category”) and 614 nonexposed
healthcare workers were enrolled during a routine examination at the Occupational Health
Unit. They were asked to fill in an anamnestic questionnaire and undergo a physical examination, serum
determination of fT3, fT4 and TSH, anti-TPO ab and anti-TG ab and ultrasound neck scan. Thyroid
nodules were submitted to fine needle aspiration biopsy when indicated.

Results:
The prevalence of thyroid diseases was statistically higher in the exposed workers compared
to controls (40% vs 29%, adPR 1.65; IC95% 1.34-2.07). In particular, the thyroid nodularity prevalence
in the exposed group was approximately twice as high as that in the controls (29% vs 13%; adPR
2.83; IC95% 2.12-3.8). No statistically significant association was found between exposure to ionizing
radiation and other thyroid diseases.

Conclusion:
In our study, mild ionizing radiation-exposed healthcare workers had a statistically higher
prevalence of thyroid diseases than the control group. The results are likely due to a closer and more
meticulous health surveillance programme carried out in the ionising radiation-exposed workers, allowing
them to identify thyroid alterations earlier than non-exposed health staff.
Alveolar Ridge Preservation: A Histomorphometric Analysis
Authors: Schnutenhaus Sigmar , Götz Werner , Dreyhaupt Jens , Rudolph Heike , Luthardt Ralph G. 
Published: November 2018

Objective:This study presents the histomorphometric findings after tooth extraction with and without Alveolar Ridge Preservation (ARP) with a collagen cone filling the socket in combination with a collagen membrane covering the socket.Materials and Methods:In a controlled randomized clinical study, 10 patients were treated with the combination material after tooth extraction. In 10 patients, the extraction sockets were left to heal without further intervention. Soft tissue, new bone formation, bone quality and bone remodeling, blood flow vascularization, and inflammation were evaluated histomorphometrically. This was performed (semi-) quantitatively using a blinded protocol.Results:The statistical evaluation showed no significant difference for any parameter. When the combination material was used, more pronounced remodeling, increased osteoblast activity, and increased vascularization were demonstrated based on the histomorphometric findings. In contrast, there were reduced levels of osteogenesis and less mineralization. There was slightly more bundle bone in patients with ARP.Conclusion:The histomorphometric analysis of ARP with a combination material consisting of a collagen cone and a collagen membrane showed no significant differences in terms of new bone formation and bone quality. Descriptively, however, different manifestations were seen that might benefit from being documented using larger samples and being tested for clinical relevance.
Health Insurance in the First 3 Months of Hemodialysis and Early Vascular Access
Authors: Lin Eugene , Mell Matthew W. , Winkelmayer Wolfgang C. , Erickson Kevin F. 
Published: November 2018

Background and objectives
Patients without Medicare who develop ESKD in the United States become Medicare eligible by their fourth dialysis month. Patients without insurance may experience delays in obtaining arteriovenous fistulas or grafts before obtaining Medicare coverage.

Design, setting, participants, & measurements
In this retrospective cohort study, we used a national registry to compare uninsured patients starting in-center hemodialysis with a central venous catheter between 2010 and 2013 with similar patients with Medicare or Medicaid. We evaluated whether insurance status at dialysis start influenced the likelihoods of switching to dialysis through an arteriovenous fistula or graft and hospitalizations involving a vascular access infection. We used multivariable logistic and Cox regression models and transformed odds ratios to relative risks using marginal effects.

Results
Patients with Medicare or Medicaid were more likely to switch to an arteriovenous fistula or graft by their fourth dialysis month versus uninsured patients (Medicare hazard ratio, 1.63; 95% confidence interval, 1.14 to 2.43; Medicaid hazard ratio, 1.23; 95% confidence interval, 1.12 to 1.38). There were no differences in rates of switching to arteriovenous fistulas or grafts after all patients obtained Medicare in their fourth dialysis month (Medicare hazard ratio, 1.17; 95% confidence interval, 0.97 to 1.42; Medicaid hazard ratio, 1.01; 95% confidence interval, 0.96 to 1.06). Patients with Medicare at dialysis start had fewer hospitalizations involving vascular access infection in dialysis months 4–12 (hazard ratio, 0.60; 95% confidence interval, 0.37 to 0.97).

Conclusions
Insurance-related disparities in the use of arteriovenous fistulas and grafts persist through the fourth month of dialysis, may not fully correct after all patients obtain Medicare coverage, and may lead to more frequent vascular access infections.
Relatorio Final de Avaliação do Projeto de Igual para Igual numa Intervenção em Rede: um estudo meta-avaliativo
Authors: Andretti Andrea Regina S. N. , Costa Maria Beatriz P. P. , Aguiar Glauco Da Silva 
Published: November 2018

O objetivo deste artigo e o de apresentar uma meta-avaliação somativa no Relatorio de Avaliação Final do Projeto “De igual para igual numa intervencao em rede” cujo objetivo foi enfrentar os problemas da pobreza e da exclusao social no Concelho Municipal de Cuba em Portugal. A regiao do Concelho de Cuba vem sofrendo ao longo do tempo um processo natural de envelhecimento populacional e de despovoamento acentuado. E uma das regioes de Portugal que possui elevados indices de redução demografica. Isso e devido, nao apenas às reduzidas formas de ocupação da população residente, mas tambem de um impotente dinamismo econômico. A metodologia norteadora do estudo meta-avaliativo realizado foi pautada nos criterios de avaliação disseminados por Davidson, ou seja, Qualidade, Utilidade, Conduta, Credibilidade e Custo. Ao final do estudo constatou-se que o Relatorio Final de Avaliação do Projeto cumpriu os criterios, com excecao do criterio Custo que nao estava presente.Palavras-chave: Meta-avaliação. Avaliação. Relatorio. Igualdade de Genero.
ANALISIS HUBUNGAN FAKTOR SOSIAL EKONOMI DENGAN PARTISIPASI ANGGOTA KELOMPOKTANI KELAS PEMULA PADA USAHATANI PADI SAWAH DI KECAMATAN SEKERNAN KABUPATEN MUARO JAMBI
Authors: Panjaitan Elliana Ester , Napitupulu Dompak , Nurfathiyah Pera 
Published: November 2018

Penelitian ini bertujuan untuk mengetahui partisipasi petani pada kelompok tani kelas pemula di Kecamatan Sekernan, untuk melihat hubungan faktor sosial ekonomi (pendidikan, luas lahan garapan, jumlah anggota keluarga, dan pendapatan) terhadap partisipasi anggota dalam kelompok tani pemula Di Kecamatan Sekernan Kabupaten Muaro Jambi.Penelitian ini dilakukan di Kecamatan Sekernan, lokasi penelitian ini dilakukan secara sengaja dengan pertimbangan Kecamatan Sekernan merupakan daerah sentra produksi tanaman padi sawah di Provinsi Jambi.Sampel pada penelitian ini adalah petani padi sawah kelas pemula.Data yang dihimpun dari penelitian ini adalah data primer dan data sekunder.Data yang diperoleh dari hasil penelitian akan disederhanakan dengan menggunakan tabulasi, kemudian dianalisis secara deskriptif melalui scoring dan persentase.Untuk melihat pengaruh tinggi atau rendah faktor sosial ekonomi denganpartisipasianggota kelompok tani kelas pemula pada usahatni padi sawah digunakan analisis statistik non parametrik melalui Uji Chi-Square (Siegel, 1997).Penelitian memperjelas bahwa tinggi rendahnya faktor sosial ekonomi berhubungan nyata dengan partisipasi anggota kelompok tani kelas pemula pada usahatani padi sawah di Kecamatan Sekernan Kabupaten Muaro Jambi. Kata Kunci : Faktor sosial ekonomi, Partisipasi anggota kelompok tani, Padi sawah
DAMPAK KRISIS EKONOMI TERHADAP PROFITABILITAS AGROINDUSTRI KERIPIK TEMPE DI KABUPATEN TEBO
Authors: Putra Dhikdaya Manggala , Napitupulu Dompak , Elwamendri Elwamendri 
Published: November 2018

Penelitian ini ditunjukan untuk mengetahui seberapa besar pendapatan dan profitabilitas yang di peroleh agroindustri keripik tempe di Kabupaten Tebo sebelum dan saat krisis ekonomi. Pemilihan lokasi penelitian dengan dasar penetapan wilayah secara sengaja (Purposive) dengan pertimbangan lokasi penelitian merupakan daerah agroindustri keripik tempe dengan jumlah 32 unit yang terletak di Kabupaten Tebo. Penelitian dilakukan dari tanggal 16 Juni 2014 sampai tanggal 16 Juli 2014 dengan metode sensus. Hasil penelitian menunjukkan bahwa terjadi penurunan pendapatan saat krisis ekonomi yang dimana sebelum krisis ekonomi rata-rata pendapatan agroindustri keripik tempe sebesar Rp. 55.697.106/tahun dan saat krisis ekonomi rata-rata pendapatan sebesar Rp. 32.694.808/tahun dengan perbedaan pendapatan sebelum dan saat krisis ekonomi sebesar Rp. 23.002.298/tahun. hal itu mengakibatkan ikut menurunnya profitabilitas saat krisis ekonomi dimana rata-rata profitabilitas sebelum krisis ekonomi sebesar 4,80% /tahun dan saat krisis ekonomi sebesar 3,01%/tahun dengan perbedaan profitabilitas sebelum dan saat krisis ekonomi sebesar 1,79%/tahun. Selain itu digunakan analisis uji beda dua rata-rata antara pendapatan dan profitabilitas sebelum krisis ekonomi dan saat krisis ekonomi yang dimana didapat hasil pendapatan dan profitabilitas agroindustri keripik tempe sebelum krisis ekonomi lebih besar dibandingkan dengan pendapatan dan profitabilitas agroindustri saat krisis ekonomi.
Kata Kunci : Krisis Ekonomi, Profitabilitas, Agroindustri, Keripik Tempe
AI-Enhanced Audit Inquiry: A Research Note
Authors: Raschke Robyn L. , Saiewitz Aaron , Kachroo Pushkin , Lennard Jacob B. 
Published: November 2018

ABSTRACTArtificial intelligence (AI) and machine learning (ML) are transforming organizations and will soon transform auditing. Many promising areas of AI and ML are within the continuous auditing context. However, the field has yet to recognize how AI and ML can be used for audit inquiry, an essential feature of both traditional audits and continuous auditing. In this research note, we discuss the potential viability of AI-enhanced audit inquiry using “bots” that automatically generate audit inquiries as well as evaluate client responses. In addition, we discuss opportunities for future research in this specific area of automated auditing.
KONDISI LAHAN KEBUN TEBU SETELAH PANEN DAN KARAKTERISTIK FISIK DAN MEKANIK SERASAH TEBUNYA
Authors: Sugandi Wahyu Kristian , Suastawa I Nengah , Wiyono Joko 
Published: November 2018

Telah disadari belakangan ini bahwa pembakaran tebu sebelum dan setelah panen dapat merusak lingkungan hidup serta mengganggu kesehatan manusia di lingkungan perkebunan tebu. Usaha-usaha untuk menangani serasah tebu yang jumlahnya sangat banyak, yang mengganggu proses budidaya tebu telah mulai dilakukan. Salah satunya adalah mencacah serasah tebu menjadi ukuran kecil untuk digunakan sebagai kompos, atau dibenamkan kembali ke dalam tanah. Proses perancangan alat atau mesin yang berkaitan dengan penanganan serasah tebu tersebut membutuhkan data pendukung sifat fisik dan mekanik serasah tebu. Data tersebut akan sangat membantu dalam menghasilkan rancangan alat dan mesin yang efektif dan efisien baik secara teknis maupun ekonomis. Metode Penelitian ini adalah analisis deskriptif yaitu melakukan pengukuran dan analisis data untuk mengetahui kondisi lahan dan karakteristik dari serasah tebu. Hasil Penelitian menunjukkan bahwa lebar guludun 120 cm, jarak tanaman 120 cm dan tinggi guludan 20 cm. Kerapatan Kamba serasah tebu 7,71 kg/cm3, : panjang rata-rata pucuk 162.5 cm, jumlah rata-rata daun per pucuk 4.1 lembar, lebar daun rata-rata 5.0 cm, tebal daun rata-rata 0.3 mm, diameter pangkal pucuk rata-rata 21.3 mm, dan berat pucuk 57.3 gram. panjang daun 161.1 cm, lebar pangkal daun 4.4 cm, lebar tengah daun 4.1 cm, lebar ujung daun 3.9 cm, tebal daun 0.3 mm, dan berat daun 8.9 gram. Keywords: Physical properties; mechanical properties; sugarcane.
Influence of Socially Disadvantaged Environment on Aggressiveness of Pupils at Primary Schools
Authors: Porubčanová Dáša , Pasternáková Lenka 
Published: November 2018

Abstract

Introduction:
The study deals with occurrence of aggressiveness of pupils from socially disadvantaged environment. It describes the socially disadvantaged environment and the level of aggression of pupils from such environments. The text describes the most important results of the research.

Methods:
Within the research, a survey was carried out, monitoring the level of aggression of the majority pupils compared to the pupils from socially disadvantaged environment. The survey was carried out personally based on a monitoring scheme of aggression of the pupils from socially disadvantaged environment. The research has been made by direct observation within 60 teaching hours at the level of 1st and 4th grade.

Results:
The findings, which we have acquired through observation, showed that the age and maturity of younger pupils’ organisms adapts to the model of social environment. Pupils from less stimulating social environments may become the victims of aggressive attacks in various forms more frequently. Types, forms and manifestations of aggression, equally subject to influence of the environment, in a school environment at the level of 10-year-old students are perceived as some form of entertainment. They join the attack on the victim for acceptance or they have the same preferences as the group. It often happens without consequences or attempts to eliminate these signs, because the seriousness of the attack is not ascribed.

Discussion:
We were interested in the differences of aggression level of the majority pupils compared to the pupils from socially disadvantaged environment in the first and the fourth year of a primary school.

Limitations:
The results apply only to students in the first level by using of the observation method.

Conclusions:
As substantial and significant for pedagogic experience, we consider implementing the research findings as well on the higher level of pupils’ education and to define further correlations between aggressive behaviour and socially disadvantaged environment.
Metode Pembelajaran “Make A Match” Dan Pengaruhnya Terhadap Hasil Belajar IPA
Authors: Pratiwi Rina Hidayati 
Published: November 2018

<p>Almost of unspecifically studying methods have been applied teacher for teaching activities. That methods have effected unefficiency for knowledge transferring to student. That is the reason how we need studying methods that efficient, creative and innovative. The purpose of this study is for knowing the studying methods “Make A Match” and how the impact to result study specifically for natural science. We use purpose sampling technics to definite research class and simple random sampling to definite part of sample of each class. The average score of experiment class are higher than control class. The different of both class is three point with normal distribution for each class and from homogeneity test showed that F hit = 1,163. Both of them have homogeneous varians. The average point of experiment class are higher than control class too. T-test showed t hit &gt; t table (3,614 &gt; 1,69). Thus, the studying methods “Make a Match” could raised the study results better than conventional methods. As the result, the quality of education can be more improved agree with contain and the purpose of studying in the school.</p>
IMPLEMENTASI METODE CONCEPT MAPPING UNTUK MENINGKATKAN HASIL BELAJAR SAINS DAN KREATIVITAS SISWA KELAS VI SDN BENER 01 TAHUN PELAJARAN 2017/2018
Authors: Sudjinah Sudjinah 
Published: November 2018

<em>The science lesson at SDN Bener 01 shows that learning is still teacher-centered. Student creativity is not yet optimal. Learning completeness with KKM 75 only reached 35% and students still tend to passive. Therefore it is necessary to improve the learning process. The purpose of this research is to find out whether the application of concept mapping method can improve the learning outcomes of science and creativity of students of class VI SDN Bener 01 in the 2017/2018 school year. Concept Mapping is a learning strategy that asks students to synthesize or draw a picture of the main concepts that are interconnected, which are marked by lines of arrows written levels that sound the form of relationships between the main concepts. This research is a Class Action Research conducted at SDN Bener 01 as much as two cycle consist of cycle I and cycle II. </em><em>Technique of collecting data using test and observation sheet of student creativity. The result of this class action research is on the first cycle student learning outcomes show mastery learning classically 59%. While the creativity of students showed 65% of students with creative criteria and 35% with creative enough criteria. The learning outcomes in cycle II showed that learning completeness in the classical reach 82%. While the creativity of students showed 29% of students with very creative category, 65% category creative enough and 6% creative enough. Increased learning outcomes from cycle I to cycle II as much as 23%. Enhancement of creativity of students as much as 29%. The conclusion of this PTK is the application of concept mapping method can improve science learning outcomes and creativity of students of class VI SDN Bener 01 Year lesson 2017/2018.</em>
Kualitas Pelayanan Pendaftaran Pengawas Pemilihan Lapangan (PPL) di Kantor Panwaslu Kecamatan Samarinda Ilir
Authors: Asnar A 
Published: November 2018

<p class="NoSpacing1">Penelitian ini memiliki tujuan untuk mengetahui Kualitas Pelayanan Pendaftaran Pengawas Pemilihan Lapangan (PPL) di Kantor Panwaslu Kecamatan Samarinda Ilir, beserta faktor-faktor yang mendukung dan menghambatnya. Jenis penelitian yang digunakan dalam penelitian ini yaitu jenis penelitian kualitatif. Teknik penarikan sampel dengan teknik <em>purposive sampling</em> dan teknik <em>accidental sampling</em>. Untuk Teknik pengumpulan data dengan wawancara, observasi, dan pencatatan dokumen. Adapun teknik analisis data, yaitu teknik analisis data model interaktif Miles dan Huberman. Hasil penelitian menunjukkan bahwa Kualitas Pelayanan Pendaftaran PPL di Kantor Panwaslu Kecamatan Samarinda Ilir secara umum sudah baik, yang dibuktikan melalui pengukuran kelima dimensi kualitas pelayanan (kehandalan, daya tanggap, kepastian, empati, dan keberwujudan). Faktor pendukungnya yaitu jumlah petugas penerima pendaftaran yang memadai dan dibekali dengan kemampuan yang mumpuni. Sedangkan penghambatnya yaitu masih kurangnya beberapa komponen fisik untuk mewujudkan pelayanan prima, seperti kursi dan ruang tunggu untuk pendaftar Pengawas Pemilihan Lapangan (PPL), televisi sebagai sarana hiburan, maupun ruang baca, yang mana hal ini disebabkan keterbatasan anggaran, dimana situasi yang ada saat ini Kantor Panwaslu Kecamatan Samarinda Ilir masih menumpang di Kantor Kecamatan Samarinda Ilir.</p>
PENGEMBANGAN PEMBELAJARAN E-LEARNING DENGAN WEB LOG SEBAGAI ALTERNATIF BAHAN AJAR GURU
Authors: Astuti Irnin Agustina Dwi , Nurullaeli Nurullaeli , Nugraha Alpi Mahisha 
Published: November 2018

<p><strong><em>Abstract.</em></strong><em>The purpose of this public service activities is to enhance the role of vocational teachers and vocational Respati 1 Respati 2 in developing innovative learning media. Innovation learning media in the form of web logs. Log web presence is expected to be maximized by teachers as an alternative medium of knowledge transmission, media on-line learning, as well as solutions to the problem of lack of conventional instructional hours in class. Web logs can be accessed by students and teachers anywhere and anytime, which is expected to motivate students to learn independently grasp the concepts of the lessons. This learning innovations make the learning process more flexible and efficient. The method in this devotion in the form of training methods, mentoring and discussion. Training is done by giving seminars creating web log and web log manufacturing practices teaching materials by teachers was held on December 15-16, 2016. The results of the training in the form of web logs each participant that can be used for the learning process. Outcomes in community service activities in the form of modules making web log.</em></p><p><strong><em>Keywords: e-learning, web log, teaching materials.</em></strong><em></em></p><p> </p><p><strong> </strong></p><p><strong>Abstrak.</strong>Tujuan kegiatan pengabdian kepada masyarakat ini yaitu untuk meningkatkan peran guru SMK Respati 1 dan SMK Respati 2 dalam mengembangkan inovasi media pembelajaran. Inovasi media pembelajaran berupa <em>web log</em>. Keberadaan <em>web log</em> diharapkan dapat dimaksimalkan oleh para guru sebagai media alternatif penyampaian pengetahuan, media pembelajaran <em>on-line</em>, serta solusi untuk masalah kurangnya jam pembelajaran konvensional di kelas. <em>Web log</em> tersebut dapat diakses oleh siswa dan guru dimana pun dan kapan pun, sehingga diharapkan dapat memotivasi siswa untuk belajar mandiri memahami konsep-konsep pelajaran. Inovasi pembelajaran ini membuat proses pembelajaran lebih fleksibel dan efisien. Metode dalam pengabdian ini berupa metode pelatihan, pendampingan, dan diskusi. Pelatihan dilakukan dengan cara memberikan seminar pembuatan <em>web log</em> dan praktik pembuatan <em>web log</em> bahan ajar oleh guru yang dilaksanakan pada tanggal 15-16 desember 2016. Hasil pelatihan berupa <em>web log</em> masing-masing peserta yang dapat digunakan untuk proses pembelajaran. Luaran dalam kegiatan pengabdian masyarakat ini berupa modul pembuatan <em>web log</em>.</p><p><strong>Kata Kunci: <em>e-learning</em>, <em>web log</em>, bahan ajar.</strong></p>