bluuebunny/crossref_metadata_2025_split huggingface dataset:
Submandibular Gland Invasion by Oral Cavity Cancers: A Systematic Review
Authors: Dundar Yusuf , Mandle Quinton , Raza Syed N. , Lin Ho‐Sheng , Cramer John , Hotaling Jeffrey M. 
Published: March 2019

ObjectiveThe submandibular gland (SMG) is typically included in level I neck dissection specimens despite limited data demonstrating SMG invasion. The main objective of this article is to determine the rate and pathways of SMG invasion by squamous cell carcinoma of the oral cavity and oropharynx.Data SourcesA systematic review of relevant studies was performed, evaluating articles identified via the PubMed, Cochrane, and Medline databases.Review MethodsDescriptive features of primary tumors, primary treatment modalities, the rate and pathway of SMG invasion, and survival outcomes, if present, were reported following the PRISMA guidelines.ResultsThe initial literature search yielded 273 articles, of which 17 met inclusion criteria. A total of 2306 patients with 2792 SMG resections were analyzed. Fifty‐eight resections (2.0%) were revealed to have tumor involvement. Among patients with SMG tumor involvement, the most common invasion pathway was direct SMG invasion by primary tumor (43 of 58, 74.1%). The second‐most common mode of SMG invasion was from involved adjacent lymph nodes (10 of 58, 17.2%). Only 3 SMG resections out of 2792 (0.1%) had isolated metastatic parenchyma without evidence of direct tumor invasion or invasion by involved lymph nodes.ConclusionGiven this rarity of SMG involvement, preservation of SMG might be feasible in selected patient population. However, additional studies need to examine the functionality of preserved SMGs among patients who receive postoperative adjuvant radiation therapy.
Condições operacionais de reservatórios em sistemas de abastecimento de água indiretos: Estudo de caso em um Campus Universitário
Authors: Jesus Djalma Santos de , Almeida Rosa Alencar Santana de 
Published: March 2019

As boas condições operacionais dos reservatórios são imprescindíveis para manutenção da qualidade da água para consumo humano. Para averiguar a situação do parque de reservatórios em um campus universitário foi aplicado um check-list. A lista foi baseada nas normas e na legislação brasileiras para construção e operação de reservatórios e para qualidade da água para consumo humano, respectivamente. O parque de reservatórios foi inspecionado e as suas condições operacionais foram avaliadas. Os resultados mostraram que, no período em que foram feitas as inspeções, nem todos os reservatórios atendiam aos padrões e recomendações estabelecidos pela NBR 5626/98 (ABNT, 1998), bem como não atendiam plenamente às demais normas e legislações vigentes. As adversidades encontradas se traduzem em vários níveis de complexidade, desde as mais simples, que carecem de poucos recursos para serem resolvidas, até problemas mais complexos que podem ser resultado de imprecisões no projeto ou falhas na execução, ou mesmo desgastes causados pelo uso e por carências de manutenção. Tais problemas envolvem maiores dificuldades para solução e requerem maiores investimentos. Diante deste cenário, são necessárias intervenções para melhorar as condições operacionais e de manutenção do parque de reservatórios, de modo a atender ao que preconizam as normas brasileiras, especialmente a NBR 5626/98 e a Portaria da Consolidação N°5, anexo XX.
Perbandingan Kadar Substansi P Serum pada Pasien Pre dan Post Operasi Tiroid yang Diberi Analgetik Bupivakain 0,25% dengan Teknik Bilateral Superficial Cervical Plexus Block (BSCPB)
Authors: Harahap C O , Wicaksono Satrio Adi , Sutiyono Doso , Sasongko Himawan 
Published: March 2019

Latar belakang: Operasi tiroid dapat menyebabkan rasa sakit sehingga untuk mencegah masalah ini dengan berbagai modalitas, seperti anestesi regional bilateral superficial cervical plexus block (BSCPB) dengan menggunakan bupivakain 0,25% yang dikombinasikan dengan anestesi umum.Metode: Penelitian ini merupakan penelitian klinis acak tersamar ganda dengan jumlah sampel 36 pasien. Sampel dibagi kedalam 2 kelompok yang diberikan anestesi regional melalui teknik BSCPB dengan kelompok perlakuan diberikan bupivakain 0,25% dibandingkan dengan kelompok kontrol yang diberikan NaCl 0,9% terhadap kadar substansi P serum pre dan post operasi pada pasien yang menjalani operasi tiroid.Hasil: Data penelitian diperoleh subjek laki-laki sebanyak 7 (19,4%) orang dan subjek perempuan sebanyak 29 (80,6%) orang. Data substansi P post operasi kelompok control dibandingkan kelompok perlakuan didapatkan perbedaan bermakna (p = 0,001). Substansi P pre operasi dibandingkan substansi P post operasi kelompok perlakuan didapatkan perbedaan bermakna (p = 0,004). Simpulan: Pemberian bupivakain konsentrasi 0,25% melalui teknik BSCPB terbukti menurunkan kadar substansi P serum post operasi.
The prevalence of potentially beneficial and harmful drug-drug interactions in intensive care units
Authors: Mehralian Hossein Ali , Moghaddasi Jafar , Rafiei Hossein 
Published: March 2019

Abstract

Background
The present study was conducted with the aim of investigating the prevalence of potentially beneficial and harmful drug-drug interactions (DDIs) in intensive care units (ICUs).

Methods
The present cross-sectional prospective study was conducted in two ICUs in Shahr-e Kord city, Iran. The study sample was consisted of 300 patients. The Drug Interaction Facts reference text book [Tatro DS. Drug interaction facts. St Louis, MO: Walters Kluwer Health, 2010.] was used to determine the type and the frequency of the DDIs.

Results
The participants consisted of 189 patients men and 111 women. The mean age of patients was 44.2 ± 24.6 years. Totally, 60.5% of patients had at least one drug-drug interaction in their profile. The total number of DDIs found was 663 (the mean of the total number of drug-drug interactions was 2.4 interactions per patient). Of all the 663 interactions, 574 were harmful and others were beneficial. In terms of starting time, 98 of the potential interactions were rapid and 565 of them were delayed. In terms of severity, 511 of the potential interactions were moderate. Some of the drugs in the patients’ medical records including phenytoin, dopamine, ranitidine, corticosteroid, dopamine, heparin, midazolam, aspirin, magnesium, calcium gluconate, and antibiotics, the type of ventilation, the type of nutrition and the duration of hospital stay were among the factors that were associated with high risk of potential DDIs (p < 0.05).

Conclusions
The prevalence of potentially beneficial and harmful DDIs, especially harmful drug-drug interactions, is high in ICUs and it is necessary to reduce these interactions by implementing appropriate programs and interventions.
Ambivalenzen des Forschens unter Bedingungen (post-) dekolonialer Praxis
Authors: Daniel Antje 
Published: March 2019

Abstract

Postcolonial Studies erleben einen erneuten Aufschwung an verschiedenen Orten des globalen Südens. Sie verweisen auf Hierarchien in der Wissensproduktion, stellen die Dominanz und Relevanz vermeintlich ‚westlicher‘ Theorien infrage und fordern eine Selbstrepräsentation des globalen Südens ein. Wie verändert sich das Forschen im globalen Süden durch eine solche gelebte dekoloniale Praxis? Welche Herausforderungen und Ambivalenzen existieren? Der folgende Beitrag beschäftigt sich mit den dekolonialen Debatten in Südafrika, welche durch die Proteste der Studierenden seit 2015 unter dem Slogan #Fees must Fall und #Rhodes must Fall vermehrt an Aufmerksamkeit erhalten. Die Relevanz dekolonialer Argumente in der Studierendenbewegung verändert dem Zugang zum Forschungsfeld und die Datenerhebung im südafrikanischen Kontext. Entstehende Ambivalenzen sowie die methodischen und epistemologischen Konsequenzen gelebter dekolonialer Praxis zeigen sich im Anspruch auf Selbstrepräsentation der Studierenden, und daraus folgend einem Ausloten neuer Erhebungsmethoden und Darstellungsformen. Diese werden besonders deutlich in der Kunstproduktion, in der Medienberichterstattung sowie in der Verwebung von Aktivismus und Forschung durch academic activism. Zugleich geht dieser Prozess mit einer Schließung des Forschungszugangs einher, welcher sich durch Skeptizismus gegenüber unbeteiligten ForscherInnen ausdrückt, der Essentialisierung struktureller Machtverhältnisse, Deutungshegemonie und der Einforderung einer ‚privilegierten Schuld‘. Die Präsenz dekolonialer Debatten in Protestbewegungen beeinflusst somit den Zugang zum Forschungsfeld als auch die Art und Schwerpunkte der Wissensproduktion in ambivalenter Art und Weise.
Jenseits von Twitter und Straßenprotest
Authors: Budniok Jan , Noll Andrea 
Published: March 2019

AbstractAusgelöst durch Energieengpässe bildeten sich in Ghana 2014 mehrere neue Protestgruppen heraus, unter ihnen Occupy Ghana und das Citizen Ghana Movement. Dasleadershipbeider Bewegungen ist mit jeweils einem Dutzend Personen relativ klein. Zur Erforschung desleadershipvon sozialen Bewegungen bieten sich insbesondere Methoden der Biographieforschung an. In ethnologischen Forschungsarbeiten wird die Biographieforschung meist mit weiteren ethnographischen Methoden wie der Teilnehmenden Beobachtung kombiniert. Zentral für die Ethnologie sind weiterhin ein Perspektivwechsel und die lange Feldforschung. Dabei erheben Ethnolog*innen sehr unterschiedliche biographische Daten und verknüpfen diese miteinander. Für den vorliegenden Artikel erhoben Jan Budniok und Andrea mit den Biographien der Mitglieder desleadershipauch ihre Familiengeschichten, um mehr über Darstellung historisch gewachsener Netzwerke zu erfahren. Zudem hängen die individuellen Beweggründe aktiv zu werden in den hier untersuchten Fällen oft mit der eigenen Familiengeschichte zusammen oder werden in einem solchen Zusammenhang dargestellt, um das eigene Handeln zu legitimieren. Diese Kombination von Biographieforschung mit weiteren ethnographischen Methoden ist eine Stärke des ethnographischen Ansatzes und kann auch von anderen Disziplinen in der Erforschung sozialer Bewegungen fruchtbar gemacht werden.
Quinoxalinedione deprotonation is important for glutamate receptor binding
Authors: Dudić Adela , Reiner Andreas 
Published: March 2019

Abstract
Quinoxalinediones are an important class of competitive antagonists at ionotropic glutamate receptors (iGluRs), where they are widely used to block α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate receptor responses. In this study we utilize two prototypic quinoxalinedione antagonists, namely DNQX and CNQX, which quench the intrinsic fluorescence of the ligand binding domain (LBD), to perform in vitro binding assays. We find that binding of DNQX and CNQX at the AMPA receptor GluA2 LBD is strongly pH dependent, whereas glutamate binding is not affected by pH. We also show that the deprotonation of DNQX, CNQX and other quinoxalinediones (NBQX and YM90K) occurs close to physiological pH, which can be explained by the lactam-lactim tautomerization of the quinoxalinedione scaffold. Analysis of our binding data indicates that quinoxalinedione deprotonation is a key requirement for binding, as we find a >100-fold higher affinity for binding of the monoanionic form compared to the neutral form. This suggests a large electrostatic contribution to the interaction with a conserved arginine residue located in the binding pocket of iGluRs. The strong pH dependence of quinoxalinedione binding, which has not previously been reported, is relevant for structure-function studies, but also for the use of quinoxalinediones in physiological experiments and envisioned therapeutic applications.
Tripterine inhibits proliferation, migration and invasion of breast cancer MDA-MB-231 cells by up-regulating microRNA-15a
Authors: Zuo Anjun , Zhao Peng , Zheng Yu , Hua Hui , Wang Xingang 
Published: March 2019

Abstract
Breast cancer is the most commonly diagnosed cancer in women worldwide. Tripterine is an important active component isolated from Triperygium wilfordii Hook F. This study investigated the effects of tripterine on breast cancer cell proliferation, migration, invasion and apoptosis, as well as microRNA-15a (miR-15a) expression. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was performed to measure the expression of miR-15a. Cell transfection was conducted to change the expression of miR-15a. Viability, proliferation, migration, invasion and apoptosis of MDA-MB-231 cells were assessed using the cell counting kit-8 (CCK-8) assay, BrdU incorporation assay, Annexin V-FITC/PI apoptosis detection kit and two-chamber Transwell assay, respectively. Expression of key factors involving in cell proliferation, migration, invasion and apoptosis, as well as the PI3K/AKT and JNK pathways, were evaluated using Western blotting. We found that tripterine inhibited MDA-MB-231 cell viability, proliferation, migration and invasion, but induced cell apoptosis. Moreover, tripterine up-regulated the expression of miR-15a in a concentration-dependent manner and miR-15a participated in the effects of tripterine on MDA-MB-231 cell proliferation, migration, invasion and apoptosis. In addition, tripterine inactivated PI3K/AKT and JNK pathways in MDA-MB-231 cells by up-regulating miR-15a. In conclusion, tripterine inhibited proliferation, migration and invasion of breast cancer MDA-MB-231 cells by up-regulating miR-15a and inactivating PI3K/AKT and JNK pathways.
Nanomedical detection and downstream analysis of circulating tumor cells in head and neck patients
Authors: Künzel Julian , Gribko Alena , Lu Qiang , Stauber Roland H. , Wünsch Désirée 
Published: March 2019

Abstract
The establishment of novel biomarkers in liquid biopsies of cancer patients has come more into focus in prognostic and diagnostic research efforts. Due to their prognostic relevance disseminated tumor cells or circulating tumor cells are the subject of intensive research and are discussed as early diagnostic indicators for treatment failure and the formation of micrometastases. A potential association of this early-systemic tumor component with poor prognosis of cancer patients could be already demonstrated for various entities including breast, colon, lung, melanoma, ovarian and prostate cancers. Thus, the detection of circulating tumor cells seems to be also applicable for minimal-invasive monitoring of therapy progress in head and neck cancer patients. A major problem of the use in clinical routine is that circulating tumor cells could not be detected by modern imaging techniques. To overcome these limitations highly sensitive detection methods and techniques for their molecular characterization are urgently needed allowing mechanistic understanding and targeting of circulating tumor cells. Especially the medical application of nanotechnology (nanomedical methods) has made valuable contributions to the field. Here, we want to provide a comprehensive overview on (nanomedical) detection methods for circulating tumor cells and discuss their merits, pitfalls and future perspectives especially for head and neck solid squamous cell carcinoma (HNSCC) patients.
A Micromixer with Two-Layer Crossing Microchannels Based on PMMA Bonding Process
Authors: Wang Jibo , Liu Guojun , Li Xinbo , He Fang , Ma Xiang 
Published: March 2019

AbstractA micromixer with two-layer crossing microchannels based on PMMA bonding process was proposed. The micromixer consists of two-layer crossing microchannels and periodic mixing chambers. The numerical simulation and parameters optimization of the micromixer were carried out in a Reynolds number range of 0.5–100 using CFD software, and the prototype of micromixer was manufactured by PMMA bonding process under certain temperature and pressure condition. The mixing performance of the micromixer was tested and verified by the mixing experiments using red-blue dye. Both the numerical and experimental results confirmed that the micromixer achieves an excellent mixing characteristics over a wide range of Reynolds numbers through generating Dean vortices and chaotic advection. At the same time, the PMMA bonding process proposed in this paper has certain application value and reference significance for expanding the application of three-dimensional flow channels in the field of microfluidics.
The Micro Data Linking-Panel: A Combined Firm Dataset
Authors: Leppert Philipp 
Published: March 2019

Abstract
The following article informs about the Micro Data Linking-Panel (hereafter MDL-Panel), a new firm

In German business statistics the statistical unit, or firm, is currently referred to as the smallest legally independent unit which keeps accounts for commercial and/or tax purposes.
dataset, available since May 2018 via the Research Data Centre of the Federal Statistical Office and the Research Data Centre of the Statistical Offices of the Federal States (RDC) (Forschungsdatenzentren der Statistischen Ämter des Bundes und der Länder (2018a, 2018b). The dataset originates from two projects funded by Eurostat over the period 2014 to 2016 with the title “Micro data linking of structural business statistics and other business statistics” (MDL). The projects combined data of various business statistics for the reference years 2008 to 2013 and were aimed at offering new perspectives on business statistics topics, which are not addressed in the ordinary publication program. Furthermore, MDL served to gain insights about the involved methodological challenges of linked data in Official Statistics. The first chapter provides background information on the projects funded by Eurostat. Chapter 2 contrasts the contents of the MDL-Panel to other products available via the RDC. The third chapter describes the scope of the dataset and its content in more detail. The article closes with future prospects for the MDL-Panel.
Crystal structure of bis[(((4-fluorophenyl)amino)methyl)triphenylphosphonium] tetrachloridocobaltate(II), C50H44Cl4CoF2N2P2
Authors: Kanchanadevi S. , Fronczek Frank R. , Arun V. , Mahalingam V. 
Published: March 2019

Abstract
C50H44Cl4CoF2N2P2, orthorhombic, Pbca (no. 61), a = 18.4662(6) Å, b = 15.2888(5) Å, c = 33.2661(10) Å, V = 9391.9(5) Å3, Z = 8, R
gt(F) = 0.0403, wR
ref(F
2) = 0.1005, T = 180.0(5) K.
Riboflavin - properties, occurrence and its use in medicine
Authors: Szczuko Małgorzata , Ziętek Maciej , Kulpa Danuta , Seidler Teresa 
Published: March 2019

Abstract
Riboflavin is built on an isoalloxazin ring, which contains three sixcarbon rings: benzoic, pyrazine and pyrimidine. Riboflavin is synthesized by some bacteria, but among humans and animals, the only source of flavin coenzymes (FAD, FMN) is exogenous riboflavin. Riboflavin transport in enterocytes takes place via three translocators encoded by the SLC52 gene. Deficiency of dietary riboflavin has wide ranging implications for the efficacy of other vitamins, the mechanism of cellular respiration, lactic acid metabolism, hemoglobin, nucleotides and amino acid synthesis. In studies it was found that, pharmacologic daily doses (100 mg) have the potential to react with light, which can have adverse cellular effects. Extrene caution should be exercised when using riboflavin as phototherapy in premature newborns. At the cellular level, riboflavin deficiency leads to increased oxidative stress and causes disorders in the glutathione recycling process. Risk factors for developing riboflavin deficinecy include pregnancy, malnutrition (including anorexia and other eating disorders, vegitarianism, veganism and alcoholism. Furthermore, elderly people and atheletes are also at risk of developing this deficiency. Widespread use of riboflavin in medicine, cancer therapy, treatment of neurodegenerative diseases, corneal ectasia and viral infections has resulted in the recent increased interest in this flavina.
Effects of Different Weekly Sets-Equated Resistance Training Frequencies on Muscular Strength, Muscle Mass, and Body Fat in Older Women
Authors: Pina Fábio L.C. , Nunes João Pedro , Schoenfeld Brad J. , Nascimento Matheus A. , Gerage Aline M. , Januário Renata S. B. , Carneiro Nelson H. , Cyrino Edilson S. , Oliveira Arli R. 
Published: March 2019

Abstract
Pina, FLC, Nunes, JP, Schoenfeld, BJ, Nascimento, MA, Gerage, AM, Januário, RSB, Carneiro, NH, Cyrino, ES, and Oliveira, AR. Effects of different weekly sets-equated resistance training frequencies on muscular strength, muscle mass and body fat in older women. J Strength Cond Res 34(10): 2990–2995, 2020—The aim of this study was to analyze the effects of different resistance training (RT) frequencies (2 vs. 3 times per week) with an equivalent number of weekly sets performed between conditions on muscular strength and body composition in older women. Forty-seven older women (65 ± 4 years) were divided into 2 groups that performed a 12-week RT program either 2 (G2x and 3 sets) or 3 (G3x and 2 sets) times per week. The groups were evaluated before and after study on measures of body composition through dual-energy x-ray absorptiometry, and muscular strength through one repetition maximum (1RM) testing. Lean soft tissue was significantly increased in both groups (G2x = +1.7%, G3x = +1.7%), while only G3x reduced body fat after the intervention period (G2x = −0.7%, G3x = −2.9%). Similarly, significant increases were noted between conditions for 1RM scores in bench press (G2x = +11.8%, G3x = +11.9%) and knee extension (G2x = +17.4%, G3x = +10.8%). The results indicate that performing 2 or 3 RT sessions per week promotes similar improvements in muscular outcomes, while training more frequently may reduce body fat after 12 weeks of weekly sets-equated RT in untrained older women.
Changes in Blood Concentration of Adenosine Triphosphate Metabolism Biomarkers During Incremental Exercise in Highly Trained Athletes of Different Sport Specializations
Authors: Włodarczyk Michał , Kusy Krzysztof , Słomińska Ewa , Krasiński Zbigniew , Zieliński Jacek 
Published: March 2019

Abstract
Włodarczyk, M, Kusy, K, Słomińska, E, Krasiński, Z, and Zieliński, J. Changes in blood concentration of adenosine triphosphate metabolism biomarkers during incremental exercise in highly trained athletes of different sport specializations. J Strength Cond Res 33(5): 1192–1200, 2019—We hypothesized that (a) high-level specialized sport training causes different adaptations that induce specific biomarker release dynamics during exercise and recovery and (b) skeletal muscle mass affects biomarker release. Eleven sprinters (21–30 years), 16 endurance runners (18–31 years), 12 futsal players (18–29 years), and 12 amateur runners as controls (22–33 years) were examined. Hypoxanthine (Hx), xanthine (X), uric acid (UA), ammonia (NH3), and lactate (LA) concentrations were determined at rest, during an incremental treadmill exercise test (every 3 minutes), and during recovery (5, 10, 15, 20, and 30 minutes after exercise). Hx, X, and UA concentration was determined from plasma, while LA and NH3 from whole blood, and muscle mass was assessed using dual X-ray absorptiometry method. At rest, during incremental exercise, and up to 30 minutes into the postexercise recovery period, sprinters had lowest Hx, X, and UA concentrations, and endurance athletes had lowest NH3 concentrations. For LA during exercise, the lowest concentrations were noted in endurance athletes, except when reaching maximum intensity, where the differences between groups were not significant. There were no significant correlations observed between skeletal muscle mass and biomarker concentration at maximal intensity and recovery in any group. In conclusion, the magnitude of exercise-induced biomarker concentration is only related to training adaptations through specific training profile but not to muscle mass. In addition, the results suggest that combined measuring of LA, NH3, and Hx concentration in blood is useful in indirectly reflecting key changes in exercise- and training-induced energy status. Further research should focus on studying how specific training sessions affect individual biomarker response in highly trained athletes.