bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resolution of pluripotential intermediates in murine hematopoietic differentiation by global complementary DNA amplification from single cells: confirmation of assignments by expression profiling of cytokine receptor transcripts
Authors: Billia Filio , Barbara Mary , McEwen Jon , Trevisan Maryanne , Iscove Norman N. 
Published: July 2002

AbstractAlthough hematopoiesis is known to proceed from stem cells through a graded series of multipotent, oligopotent, and unipotent precursor cells, it has been difficult to resolve these cells physically one from another. There is, therefore, corresponding uncertainty about the exact distribution and timing of the expression of genes known to be important in hematopoietic differentiation. In earlier work, the generation of a set of amplified complementary DNAs (cDNAs) from single precursor cells was described, whose biologic potential was determined by the outcome of cultured sibling cells. In this study, the new acquisition of cDNA from multipotent myeloid precursor cells is described, as is the mapping of RNA-level expression of 17 distinct cytokine receptors (c-kit, Flk-1, Flk-2/Flt-3, c-fms, gp130, erythropoietin receptor, GM-CSFRα, G-CSFR, TNFR1, IL-1RI, IL-1RII, IL-2Rβ, IL-3-specific β receptor, IL-4R, IL-6Rα, IL-7Rα, and IL-11Rα) to the enlarged sample set, spanning stages from pentapotent precursors through oligopotent intermediates to committed and maturing cells in the myeloid and lymphoid lineages. Although the enhanced scope and resolving power of the analysis yielded previously unreported observations, there was overall agreement with known biologic responsiveness at individual stages, and major contradictions did not arise. Moreover, each precursor category displayed a unique overall pattern of hybridization to the matrix of 17 receptor probes, supporting the notion that each sample pool indeed reflected a unique precursor stage. Collectively, the results provide supportive evidence for the validity of the cDNA assignments to particular stages, the depth of the information captured, and the unique capacity of the sample matrix to resolve individual stages in the hematopoietic hierarchy.
Variable heavy-chain gene analysis of follicular lymphomas: subclone selection rather than clonal evolution over time
Authors: Aarts Wilhelmina M. , Bende Richard J. , Bossenbroek Janneke G. , Pals Steven T. , van Noesel Carel J. M. 
Published: July 2002

AbstractTo investigate B-cell receptor evolution in follicular lymphomas (FLs), immunoglobulin variable heavy chain (VH) gene regions of 3 FLs were analyzed at different time points. One FL with a high somatic mutation load and intraclonal VH gene diversity was investigated in situ. VH gene transcripts were amplified and sequenced from samples of approximately 50 tumor cells isolated from frozen tissue sections by laser microdissection. Interestingly, the mutation pattern of the prevalent subclone in the relapse biopsy was virtually identical to that of a subclone isolated by microdissection from the presentation biopsy 9 years earlier. In a second FL, proof was obtained that the subclone that dominated the relapse sample had already been present in the initial biopsy. The finding that subclones found in the relapses of these FLs had not evolved over time but were preexistent, challenges the concept of antigen-driven B-cell receptor evolution during disease course.
Aberrant dimerization of von Willebrand factor as the result of mutations in the carboxy-terminal region: identification of 3 mutations in members of 3 different families with type 2A (phenotype IID) von Willebrand disease
Authors: Enayat M. Said , Guilliatt Andrea M. , Surdhar Gurcharan K. , Jenkins P. Vincent , Pasi K. John , Toh Cheng Hock , Williams Michael D. , Hill Frank G. H. 
Published: July 2002

AbstractThe 3′ end of the VWF gene was screened in the affected members of 3 different families with type 2A (phenotype IID) von Willebrand disease (vWD). Exons 49 to 52 of the VWF gene were amplified and screened for mutations by chemical cleavage mismatch detection. Mismatched bands were detected in exon 52 of 2 patients and in exon 51 of a third patient. Using direct DNA sequencing, a heterozygous G8562A transition leading to a Cys2008Tyr substitution was found in all the patients in family 1, and a T8561A transversion leading to a Cys2008Ser substitution was found in both patients from family 2. In a patient from a third family, an 8-base deletion from nucleotide 8437 to 8444 was identified in exon 51. The 2 mutations in exon 52 were reproduced by in vitro site-directed mutagenesis of full-length von Willebrand factor (vWF) cDNA and transiently expressed in COS-7 cells. The corresponding recombinant VWFs for these 2 mutations exhibited the typical aberrant vWF:Ag multimer pattern seen in the plasma of the patients. These 3 mutations demonstrate the importance of other carboxy-terminal cysteines in addition to the reported Cys2010 residue, in the normal dimerization of vWF, and their essential role in the assembly of normal multimeric vWF.
How Spiteful Are We? Validation of the Spitefulness Scale in Spaniards
Authors: Pineda David , Rico‐Bordera Pilar , Ballester‐Pascual Miriam , Piqueras José A. , Galán Manuel 
Published: November 2024

ABSTRACTSpitefulness has been defined as the willingness to cause some kind of harm to other people, even if this action does not bring any benefit and causes harm to herself. Given its relationship with a multitude of antisocial behaviors, interest in studying this trait has been growing and it was in 2014 when the first scale to measure it was validated: the Spitefulness Scale. This study aimed to examine the psychometric properties of its Spanish version. In a sample of 758 participants (M = 31.44; SD = 12.91; 72.80% female), the Spitefulness Scale, the Short Dark Triad, the Assessment of Sadistic Personality, the HEXACO‐60, and the Global Assessment of Internet Trolling were administered. Results showed the unidimensionality of the scale, adequate reliability indices, and construct validity, evidenced by positive relationships with the Dark Tetrad traits and trolling behavior. Additionally, the analysis revealed significant gender differences, with males scoring higher on spitefulness. This Spanish validation allows us to establish a solid basis for cross‐cultural comparisons. Understanding this trait, considered like the Dark Tetrad traits an antagonistic personality trait, has important implications for understanding the interpersonal and social dynamics. Given that spitefulness is closely related to aggressive behaviors, it is essential to study it to understand the underlying mechanisms of aggression and hostility in social interactions.
The Pleasure of Revenge Predicts Both Vengeful and Benevolent Motivations Toward the Provocateur
Authors: Dyduch‐Hazar Karolina , Mrozinski Blazej , Golec de Zavala Agnieszka 
Published: November 2024

ABSTRACTThree studies (N = 860) examined whether the pleasure of revenge predicts both vengeful and benevolent motivations toward the provocateur. Across all studies, self‐reported positive affect was higher, whereas self‐reported negative affect was lower after an instance of revenge. Furthermore, the revenge‐related positive affect predicted greater subsequent vengeful and benevolent motivations toward the provocateur (but more consistently the former). These findings replicate and extend previous research on affect‐improving qualities of revenge. They allow for a more nuanced understanding of the reinforcing nature of vengeful pleasure. Moreover, they suggest that the pleasure of revenge might be harnessed to promote forgiveness.
Hydrogen‐Driven Phase Differentiation in BN Nucleation on Diamond
Authors: Cheng Ting , Bets Ksenia V. , Yakobson Boris I. 
Published: November 2024

AbstractBoron nitride has attracted scientific interest in recent years due to its potential use in electronics, both as hexagonal (hBN) and cubic (cBN) phases. While both are successfully realized through chemical vapor deposition, the heteroepitaxial growth of cBN on another iconic semiconductor, diamond is plagued with mixed‐phase formation. Employing first‐principles computations and a nanoreactor approach, the BN phase preferences are explored on diamond (001) controlled—as it is discovered—by the hydrogen gas concentration. In a limited‐hydrogen environment, the initial BN‐island expands along the diamond surface, forming a 3D metastable cubic phase that grows in the direction normal to the basal plane through kinetically‐limited nucleation, thus overcoming the thermodynamic preference toward the hBN phase. Comparatively, the amorphous phase is favored in the absence of hydrogen, while the hexagonal phase dominates at its high levels, elucidating numerous experimental observations. A obtained kinetic phase diagram connects the phase with hydrogen chemical potential to facilitate targeted phase selection. The results suggest that gas‐mediated nucleation kinetics provide feasible control for the precise synthesis. It also offers valuable guidance for the controllable synthesis of desired BN phases and advances research toward potential BN electronics.
Zeolite‐Based “Particle Board” Membranes for Rapid and Selective Hydrogen Permeation
Authors: Pang Jia , Qiao Lu , Wang Hongbin , Zhang Caiyan , Yu Liting , Fan Weidong , Fan Lili , Wang Rongming , Kang Zixi , Sun Daofeng 
Published: November 2024

AbstractZeolites, with their well‐defined pore sizes and outstanding stability, are regarded as the quintessential material for precise molecular separation tasks. However, the leap from easily produced zeolite powders to synthesizing free‐standing zeolite membranes, which can fully leverage their ordered porosity, presents substantial technical hurdles. Addressing this challenge, this study introduces polymers of intrinsic microporosity (PIM‐1) as adhesives through a wrapping‐compression method for the facile fabrication of high‐performance and free‐standing zeolite (FAU) “particle board” membranes. The 3D tomogram reconstruction from the focused ion beam‐scanning electron microscope images reveals the “particle board” membranes exhibit hierarchical porous structures. The non‐interconnecting macropores between zeolite particles facilitate the rapid H2 permeation, and the zeolites’ ordered micropores sieve the gas molecules. The optimized FAU@PIM‐1 free‐standing membrane with hierarchically pore structures demonstrated hydrogen permeance (2240 GPU) alongside H2/CH4 selectivity (31.68) for mixed gas and maintained this performance level under pressure ranges from 1.2 to 4.0 bar and over protracted operational periods (up to 3200 h). Meanwhile, EMT and MFI‐type zeolites have also been successfully applied to validate the versatility of this method, demonstrating its widespread potential for the fabrication of various free‐standing zeolite membranes.
Extremely Ultrahigh Stretchable Starch‐Based Hydrogels with Continuous Hydrogen Bonding
Authors: Zhao Jing , Chen Ran , Cheng Dongmin , Yang Xinyi , Zhang Hong , Zheng Junping , Hu Ruofei 
Published: November 2024

AbstractNatural polysaccharides‐based hydrogels have drawn extensive attention yet have been plagued by less desirable stretchability due to their inherent nature. Here, ultra‐stretchable starch‐based hydrogels (amylopectin/polyacrylamide, AAM) are developed by constructing reversible intramolecular physical interactions. This strategy endows the hydrogel with exceedingly ultrahigh deformation due to a continuous hydrogen bonding network. It can be stretched from less than 0.5 to >300 cm without breakage that the elongation exceeds 600 times the original length. The elongation collected by the universal testing machine reaches up to 36 000% without breakage outperforming previous reports and demonstrating extraordinary stretchability. Furthermore, an interwoven structure of hydrogen bonding interaction and trace covalent bonds make the stress of hydrogel reach 0.28 MPa, accompanied by an ultra‐high strain of 22 500% and significant toughness (47 MJ·m−3). The hydrogel displays high transparency (≈93%), low‐temperature resistance, moisturizing property, and extraordinary interfacial adhesion property. Intriguingly, the aqueous precursor can act as inks to prepare various forms of hydrogel within minutes through the facile writing or drawing method. This hydrogel verifies strong potential in both fields of human motion sensor (After long‐term or low‐temperature conditions) and energy storage. This study will facilitate the progress of ultra‐stretchable or multifunctional hydrogels.
Nanotechnology for Nasopharyngeal Cancer Therapy and Improving Drug Stability and Biodistribution
Authors: Shao Minmin , Moradialvand Madineh , Della Sala Francesca , Khorsandi Zahra , Borzacchiello Assunta , Paiva‐Santos Ana Cláudia , Zare Ehsan Nazarzadeh , Hushmandi Kiavash , Wang Xiangdong , Iravani Siavash , Makvandi Pooyan , Xu Yi 
Published: November 2024

AbstractNasopharyngeal cancer (NPC) is a challenging malignancy with a poor prognosis due to late diagnosis and resistance to conventional treatments. Nanotechnology offers promising solutions to address these limitations by enabling targeted drug delivery, enhancing therapeutic efficacy, and facilitating multimodal treatment strategies. By leveraging the unique properties of nanomaterials and nanocarrier systems, innovative approaches for early detection, targeted treatment, and multimodal therapy can be developed, paving the way for more effective and personalized management of NPC. This review provides a comprehensive overview of recent developments and applications of nanotechnology in NPC therapy, focusing on improving drug stability, biodistribution, and targeted delivery to NPC tumors.
Copper(I)‐Catalyzed Proto/Carboboration of Enyne Boronates for the Synthesis of Densely Substituted Diene Diboronates
Authors: Ghosh Suman , Chakrabortty Rajesh , Kumar Shailendra , Ganesh Venkataraman 
Published: November 2024

AbstractA copper‐catalyzed carbo‐/protoboration of boryl enynes is disclosed, providing access to an array of penta‐ and hexasubstituted diboryl dienes in a chemo‐, regio‐ and stereoselective manner. All six positions of the dienes can be manipulated using this methodology. The hexasubstituted diene boronates adopt a skew conformation. An iterative Suzuki coupling of the products provided highly conjugated trienes and tetraenes.
Rational Design of Two Well‐Compatible Dimeric Acceptors Through Regulating Chalcogen‐Substituted Conjugated Backbone Enable Ternary Organic Solar Cells with 19.4% Efficiency
Authors: Feng Wanying , Bai Yuyang , Wang Jia , Zhong Yanyi , Wang Jiaying , Chen Tianqi , Zhang Jiangbin , Han Kai , Wan Xiangjian , Kan Bin , Chen Yongsheng 
Published: November 2024

AbstractTo enhance the performance of dimeric acceptors (DMAs) based organic solar cells (OSCs), two new DMAs, designated as DC9‐HD and DYSe‐3, are rationally developed and employed to fabricate ternary OSCs. The substitution of the sulfur atom on the outer ring of the fused‐ring core of DC9‐HD with a selenium atom resultes in the red‐shifted DYSe‐3. Despite these minor differences, DC9‐HD and DYSe‐3 possess nearly identical conjugated skeletons, which contribute to their similar packing motifs and crystallinities, ultimately enabling a high degree of miscibility between two DMAs. Upon incorporating DYSe‐3 into the host PM6:DC9‐HD binary blend, fibril‐like morphologies featured with diameters of ≈16.9 nm and reduced charge recombination are observed in the PM6:DC9‐HD:DYSe‐3 ternary blend. More importantly, owing to their long exciton diffusion lengths and low voltage losses, a remarkable power conversion efficiency of 19.4% is achieved for the ternary OSCs, alongside a delicate balance between open‐circuit voltage and short‐circuit current density. This super result is comparable to the best performance of oligomer acceptor based OSCs reported to date. Furthermore, the proposed ternary strategy, which combines one polymer donor and two well‐compatible DMAs, not only retains the advantages of DMAs but also offers a streamlined approach for fabricating high‐performance ternary OSCs.
Anthropometric Studies of Schoolchildren During the First Decades of the 20th Century in Spain and Argentina
Authors: Cesani María Florencia , Montero Marisa González , Serrano María Dolores Marrodán 
Published: November 2024

ABSTRACTObjectiveThe practice of anthropometry in schools at the beginning of the 20th century originated in Europe and Latin America in conjunction with the emergence of hygienism and epidemiological auxology. The aim of this work is to deepen the knowledge of these practices in Spain and Argentina and to compare the available growth data in order to identify possible differences between the populations.MethodsThe anthropometric data of 1693 boys and girls aged 7–15 years (877 Spanish; 816 Argentinean) from the period between 1903 and 1913 were analyzed. The data were taken from the Reports and Memoirs of the School Colonies of the National Pedagogical Museum (Spain) and the Archives of Pedagogy and Related Sciences of the Faculty of Law and Social Sciences of the National University of La Plata (UNLP) (Argentina).ResultsThe most pronounced differences in weight and height were observed between the ages of 11 and 12. The weight growth of Spanish schoolchildren was 22% (boys) and 24% (girls) lower than that of their Argentine counterparts, while linear growth was about 7% lower for both sexes. In addition, the Spanish had a lower body mass index up to the age of 12 years.ConclusionsArgentine boys and girls of La Plata were taller and heavier than their Spanish counterparts of Madrid during the same period (between 1903 and 1913). These results can be attributed to the higher standard of living that characterized the Argentine population at that time.
Relative facial width, and its association with canine size and body mass among chimpanzees and bonobos: Implications for understanding facial width‐to‐height ratio expression among human populations
Authors: Balolia Katharine L. , Baughan Kieran , Massey Jason S. 
Published: November 2024

AbstractObjectivesFacial width‐to‐height ratio (fWHR) has been widely investigated in the context of its role in visual communication, though there is a lack of consensus about how fWHR serves as a social signal. To better understand fWHR variation in a comparative context, we investigate the associations between fWHR and canine crown height (CCH) and body mass, respectively, among two chimpanzee subspecies (Pan troglodytes schweinfurthii, Pan troglodytes troglodytes) and bonobos (Pan paniscus).Materials and MethodsWe collected landmark data from 3D surface models of 86 Pan cranial specimens to quantify fWHR and upper CCH, and to estimate body mass. We used Spearman's r and Kruskal‐Wallis tests to test for significant relationships among variables, and to assess sexual dimorphism.ResultsThere is an inverse relationship between fWHR and CCH in both sexes of Pan, however there are interpopulation differences in the relationship between fWHR and CCH among Pan taxa. Pan paniscus have relatively wide faces and small canine crowns, and wide faces in Pan t. schweinfurthii males may be driven by body size constraints. Pan troglodytes and Pan paniscus show fWHR dimorphism, and Pan paniscus have significantly higher fWHRs than do either Pan troglodytes subspecies.DiscussionOur findings indicate that CCH and facial breadth may serve subtly different signaling functions among Pan taxa. Further research into the circumstances in which wide faces evolved among chimpanzees and bonobos will likely afford deeper insights into the function of relatively wide faces in the context of visual signaling among humans and our extinct hominin relatives.
Sulfurized Composite Interphase Enables a Highly Reversible Zn Anode
Authors: Wu Lu , Yuan Hao , An Yongkang , Sun Jianguo , Liu Yu , Tang Han , Yang Wei , Cui Lianmeng , Li Jinghao , An Qinyou , Zhang Yong‐Wei , Xu Lin , Mai Liqiang 
Published: November 2024

AbstractThe stability and reversibility of Zn anode can be greatly improved by in situ construction of solid electrolyte interphase (SEI) on Zn surface via a low‐cost design strategy of ZnSO4 electrolyte. However, the role of hydrogen bond acceptor ‐SO3 accompanying ZnS formation during SEI reconstruction is overlooked. In this work, we have explored and revealed the new role of ‐SO3 and ZnS in the in situ formed sulfide composite SEI (SCSEI) on Zn anode electrochemistry in ZnSO4 aqueous electrolytes. Structure characterization and DFT demonstrate that the introduction of ‐SO3 can not only reduce the dehydration energy of [Zn(H2O)6]2+, but also enhance the stability of the ZnS/Zn interface and homogenize the ZnS/Zn interface electric field, thereby significantly improving the dynamic kinetics and uniform deposition of Zn2+. Owing to the synergistic effect of ZnS and ‐SO3, a high cycling stability of 1500 h with a cumulative‐plated capacity of 7.5 Ah cm−2 at 10 mA cm−2 has been achieved within the symmetrical cell. Furthermore, the full cell with NH4V4O10 cathode exhibits outstanding cyclic stability, exceeding 2000 cycles at 5 A g−1 and maintaining a Coulombic efficiency of 100 %. These new insights into anionic synergistic strategy could significantly enhance the practical application of zinc‐ion batteries.
Regulated Charge Transfer in Donor‐Acceptor Metal–Organic Frameworks for Highly‐Sensitive Photodetectors
Authors: Xu Zhiyun , Chandresh Abhinav , Mauri Anna , Esmaeilpour Meysam , Monnier Vincent , Odobel Fabrice , Heinke Lars , Wenzel Wolfgang , Kozlowska Mariana , Diring Stéphane , Haldar Ritesh , Wöll Christof 
Published: November 2024

AbstractIn photo‐induced charge separation, organic thin films with donor and acceptor chromophores are vital for uses such as artificial photosynthesis and photodetection. The main challenges include optimizing charge separation efficiency and identifying the ideal acceptor/donor ratio. Achieving this is difficult due to the variability in molecular configurations within these typically amorphous organic aggregates. Metal–organic frameworks (MOFs) provide a structured solution by enabling systematic design of donor/acceptor blends with adjustable ratios within a crystalline lattice. We demonstrate this approach by incorporating donor and acceptor naphthalenediimide (NDI) chromophores as linkers in a highly oriented, monolithic MOF thin film. By adjusting the NDI acceptor linker concentration during the layer‐by‐layer assembly of surface‐anchored MOF thin films (SURMOFs), we significantly enhanced charge separation efficiency. Surprisingly, the optimum acceptor concentration was only 3 %, achieving a forty‐fold increase in photodetection efficiency compared to baseline NDI donor‐based SURMOFs. This unexpected behaviour was clarified through theoretical analysis enabled by the well‐defined crystalline structure of the SURMOFs. Using density functional theory and kinetic Monte Carlo simulations, we identified two opposing effects from acceptors: the positive effect of suppressing undesirable charge carrier recombination is offset at high concentrations by a reduction in charge‐carrier mobility.