bluuebunny/crossref_metadata_2025_split huggingface dataset:
Presença de lactose em medicamentos isentos de prescrição
Authors: Barrientos Marcia Otto , Teixeira Fernanda Cristina Figueira , Araújo Roberto Paulo Correia de 
Published: December 2018

<p><strong>Introdução: </strong>A polifarmácia e a automedicação estão presentes na população brasileira, sendo frequente sua ocorrência com medicamentos isentos de prescrição. Ademais, a lactose é utilizada como excipiente em formas farmacêuticas sólidas. <strong>Objetivo:</strong> O presente estudo constitui uma pesquisa sobre lactose, na condição de excipiente, em medicamentos isentos de prescrição (MIPs). <strong>Metodologia: </strong>Em 391 MIPs presentes em cinco formas farmacêuticas sólidas e analisadas por classes, categorias e marcas, foram coletadas, nos meses de abril e maio de 2018, informações quanto à presença de lactose em bulas disponíveis nos sites da Agência Nacional de Vigilância Sanitária e da indústria farmacêutica no Brasil. <strong>Resultados: </strong>Constatou-se que a lactose está presente em 43,48% dos MIPs, sendo mais frequente nos comprimidos e comprimidos revestidos, nas proporções de 42,94% e 36,47%, respectivamente. Ela foi encontrada, predominantemente, em medicamentos similares, principalmente antialérgicos, analgésicos não opioides e anti-inflamatórios não esteroides, bem como na totalidade dos antidiarreicos e laxantes. Das 88 marcas analisadas, 30 apresentaram mais de 50% dos produtos com lactose. Identificou-se um percentual expressivo de medicamentos utilizados no controle dos sintomas de intolerância à lactose que continham esse carboidrato como excipiente. <strong>Conclusão:</strong> Nas formas farmacêuticas analisadas, a presença de lactose nos MIPs é superior a 40%. A lactose presente pode ser agravante de sintomas gastrintestinais. Portanto, é essencial incluir, na embalagem dos medicamentos, a frase de alerta sobre a presença desse açúcar, visando à sua ampla divulgação, particularmente dirigida aos indivíduos com restrição de uso dessa substância.</p>
Late translational research: putting forward a new model for developing new anti‐cancer treatments that addresses the needs of patients and society
Authors: Lacombe Denis , Bogaerts Jan , Tombal Bertrand , Maignen François , Osipienko Leeza , Sullivan Richard , Golfinopoulos Vassilis 
Published: December 2018

Bringing therapeutic innovation and the latest science to routine patient care, while safeguarding principles of affordability and equality, is a challenging mission in the current complex multi‐stakeholder environment. Precision oncology and new approaches to clinical trials (methods and clinical setting) have dramatically changed clinical research and the clinical development of new treatments. Improved understanding of molecular biology and immunology paves the way for innovative pharmacological approaches. However, we argue that the evidence generated during the clinical development of these new products for the purpose of obtaining marketing authorisations often does not address fundamental questions concerning the impact of these new interventions on the most relevant clinical outcomes: namely, quality of life and patient survival. Similarly, patient populations (for example defined by biomarkers), treatment duration, and sequence and combination of treatments within current treatment pathways are often poorly defined by clinical developments for regulatory purposes. Finally, the lack of integrated translational research within the pathway of development is a major limiting factor to delivering cost‐effective and affordable, evidence‐based care to clinical practice. This leaves many gaps in the knowledge on the efficacy and therapeutic use of medicines, which can impose a significant financial burden on healthcare systems, possibly to the detriment of more cost‐effective interventions. We argue that policy changes are required to integrate clinical research and healthcare to inform clinical practice. New routes toward optimising the integration of drug development and care are being proposed to achieve this ultimate goal.
High‐Performance Flexible Self‐Powered Photodetector Based on Perovskite and Low‐Temperature Processed In2S3 Nanoflake Film
Authors: Wang Meng , Cao Fengren , Meng Linxing , Tian Wei , Li Liang 
Published: December 2018

AbstractFlexible and self‐powered perovskite photodetectors have attracted great attention due to their potential applications in the field of portable devices, sensing, and communication. Considering the physical principle of self‐power and poor resistance to high temperature of flexible polymer substrates, it is challenging to develop low‐temperature processed inorganic materials as carrier transfer layers to integrate with perovskite. Herein, a flexible self‐powered perovskite photodetector on tin‐doped indium oxide/polyethylene naphthalate substrate based on indium sulfide (In2S3) nanoflake film grown at a low temperature below 373 K is demonstrated. The device shows a detectivity up to 1.1 × 1011 Jones at +0.5 V and response time less than 200 ms. A responsivity of 451 mA W−1 at 720 nm is also achieved, which is close to the performance of device on rigid fluorine‐doped tin oxide substrate. The device exhibits outstanding stability without obvious performance degradation after 500 cycles of bending or under a 0.0025 m bending radius. Interestingly, the device can work in the outdoor to track the sunlight change for 1 day. This result opens a door to explore the integration of inorganic semiconductors with perovskite toward flexible self‐powered photodetectors built on polymer substrates.
Prediction of Driver Modules via Balancing Exclusive Coverages of Mutations in Cancer Samples
Authors: Gao Bo , Zhao Yue , Li Yang , Liu Juntao , Wang Lushan , Li Guojun , Su Zhengchang 
Published: December 2018

AbstractMutual exclusivity of cancer driving mutations is a frequently observed phenomenon in the mutational landscape of cancer. The long tail of rare mutations complicates the discovery of mutually exclusive driver modules. The existing methods usually suffer from the problem that only few genes in some identified modules cover most of the cancer samples. To overcome this hurdle, an efficient method UniCovEx is presented via identifying mutually exclusive driver modules of balanced exclusive coverages. UniCovEx first searches for candidate driver modules with a strong topological relationship in signaling networks using a greedy strategy. It then evaluates the candidate modules by considering their coverage, exclusivity, and balance of coverage, using a novel metric termed exclusive entropy of modules, which measures how balanced the modules are. Finally, UniCovEx predicts sample‐specific driver modules by solving a minimum set cover problem using a greedy strategy. When tested on 12 The Cancer Genome Atlas datasets of different cancer types, UniCovEx shows a significant superiority over the previous methods. The software is available at: https://sourceforge.net/projects/cancer‐pathway/files/.
A pH/ROS Cascade‐Responsive Charge‐Reversal Nanosystem with Self‐Amplified Drug Release for Synergistic Oxidation‐Chemotherapy
Authors: Dai Liangliang , Li Xiang , Duan Xianglong , Li Menghuan , Niu Peiyun , Xu Huiyun , Cai Kaiyong , Yang Hui 
Published: December 2018

AbstractPoor cell uptake of drugs is one of the major challenges for anticancer therapy. Moreover, the inability to release adequate drug at tumor sites and inherent multidrug resistance (MDR) may further limit the therapeutic effect. Herein, a delivery nanosystem with a charge‐reversal capability and self‐amplifiable drug release pattern is constructed by encapsulating β‐lapachone in pH/ROS cascade‐responsive polymeric prodrug micelle. The surface charge of this micellar system would be converted from negative to positive for enhanced tumor cell uptake in response to the weakly acidic tumor microenvironment. Subsequently, the cascade‐responsive micellar system could be dissociated in a reactive oxygen species (ROS)‐rich intracellular environment, resulting in cytoplasmic release of β‐lapachone and camptothecin (CPT). Furthermore, the released β‐lapachone is capable of producing ROS under the catalysis of nicotinamide adenine dinucleotide (NAD)(P)H:quinone oxidoreductase‐1 (NQO1), which induces the self‐amplifiable disassembly of the micelles and drug release to consume adenosine triphosphate (ATP) and downregulate P‐glycoprotein (P‐gp), eventually overcoming MDR. Moreover, the excessive ROS produced from β‐lapachone could synergize with CPT and further propagate tumor cell apoptosis. The studies in vitro and in vivo consistently demonstrate that the combination of the pH‐responsive charge‐reversal, upregulation of tumoral ROS level, and self‐amplifying ROS‐responsive drug release achieves potent antitumor efficacy via the synergistic oxidation‐chemotherapy.
Terminal osseous dysplasia with pigmentary defects (TODPD) in a Turkish girl with new skin findings
Authors: Azakli Hülya , Akkaya Ayse Deniz , Aygün Murat Serhat , Demirkesen Cüyan , Eraslan Serpil , Kayserili Hülya 
Published: December 2018

AbstractTerminal osseous dysplasia with pigmentary defects (TODPD; MIM #300244) is an extremely rare, X‐linked dominant, in utero male‐lethal disease, characterized by skeletal dysplasia of the limbs, pigmentary defects of the skin, and recurrent digital fibromatosis of childhood. Delayed/abnormal ossification of bones of the hands and feet, joint contractures, and dysmorphic facial features may accompany. A single recurrent mutation (c.5217 G>A) of the FLNA gene which causes cryptic splicing was identified as the cause of the disease. We here present the first TODPD case from Turkey with full‐blown phenotype who exhibit unique additional findings, hypopigmented patch on the lower extremity following Blaschko's lines and smooth muscle hamartoma of the scalp in review of all the previously reported TODPD cases.
Development of alginate‐gum acacia‐Ag0 nanocomposites via green process for inactivation of foodborne bacteria and impact on shelf life of black grapes (Vitis vinifera)
Authors: Kanikireddy Vimala , Kanny Krishnan , Padma Y. , Velchuri Radha , Ravi G. , Jagan Mohan Reddy B. , Vithal Muga 
Published: December 2018

ABSTRACTThe main objective of this investigation is to develop sodium alginate‐gum acacia‐silver nanocomposite films (AGA‐Ag0 NC) to inhibit the growth of foodborne and to extend the shelf life of food. The Ag nanoparticles were generated in sodium alginate‐gum acacia (AGA) blend matrix through reduction by basil leaves (Tulasi). The formation of Ag0 was monitored by UV–vis spectroscopy (UV–Vis), Fourier transform infrared spectroscopy (FTIR), thermogravimetrical analysis (TGA), X‐ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The absorption band at 420 nm in UV–vis spectrum and change in the band positions in FTIR spectrum of AGA‐Ag0 NC compared to that of AGA corresponds to the formation of Ag nanoparticles. The XRD profile of AGA‐Ag0 NC exhibits characteristic d‐lines of Ag nanoparticles. The spherical shape of Ag nanoparticles uniformly formed throughout the films was recognized in SEM image with a size of ~ 4 ± 1 nm as observed by TEM. The water uptake and mechanical properties of the films were also studied. The AGA‐Ag0NC films offered excellent antimicrobial activity against various foodborne bacteria and shelf life of food enhanced efficiency of the AGA‐Ag0NC films is also tested on grape fruit (Vitus vinifera). © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47331.
Harnessing the Sustainable Development Goals for businesses: A progressive framework for action
Authors: Redman Aaron 
Published: December 2018

AbstractBusinesses, as with other sectors in society, are not yet taking sufficient action towards achieving sustainability. The United Nations recently agreed upon a set of Sustainable Development Goals (SDGs), which if properly harnessed, provide a framework (so far lacking) for businesses to meaningfully drive transformations to sustainability. This paper proposes to operationalize the SDGs for businesses through a progressive framework for action with three discrete levels: communication, tactical, and strategic. Within the tactical and strategic levels, several innovative approaches are discussed and illustrated. The challenges of design and measurement as well as opportunities for accountability and the social side of Sustainability, together call for transdisciplinary, collective action. This paper demonstrates feasible pathways and approaches for businesses to take corporate social responsibility to the next level and utilize the SDG framework informed by sustainability science to support transformations towards the achievement of sustainability.
Associations between childhood abuse, mental health problems, and suicide risk among male prison populations in Spain
Authors: Caravaca Sánchez Francisco , Ignatyev Yuriy , Mundt Adrian P. 
Published: December 2018

AbstractBackgroundThere are few studies exploring associations between different types of childhood abuse and mental health problems among adult prisoners.AimsTo explore associations between history of childhood abuse, depression or anxiety, and near‐lethal suicide attempts among adult prisoners, and test the hypothesis that post‐traumatic stress disorder (PTSD) may be a mediator between childhood abuse and adult disorder among prisoners.MethodWe enrolled 943 men from three prisons in Spain. Childhood abuse was assessed with the Childhood Trauma Questionnaire at interview and current symptoms were assessed using the 21‐item Depression Anxiety and Stress Scale (DASS‐21). Self‐reported histories of near‐lethal suicide attempts were recorded.ResultsOverall, 360 (40%) of the men reported at least one type of childhood abuse; 231 (24.5%) described exposure to emotional abuse, 236 (25%) to physical abuse, and 97 (10%) to sexual abuse. Survivors of all types of childhood abuse had over twice the prevalence of severe depression, anxiety, stress disorder, and near‐lethal suicide attempts than men who had not been exposed. Survivors of sexual and emotional violence during childhood had more symptoms of PTSD than survivors of physical abuse. Statistically, PTSD had a mediating effect, but it was very small.ConclusionsAlthough other studies have shown high rates of childhood abuse histories among prisoners, this is the first to link such a history to near‐lethal suicide attempts in this population.
Insight into the Correlation between Cu Species Evolution and Ethanol Selectivity in the Direct Ethanol Synthesis from CO Hydrogenation
Authors: Li Xiao‐Li , Yang Guo‐Hui , Zhang Meng , Gao Xiao‐Feng , Xie Hong‐Juan , Bai Yun‐Xing , Wu Ying‐Quan , Pan Jun‐Xuan , Tan Yi‐Sheng 
Published: December 2018

AbstractCu/SiO2 catalyst was prepared by the ammonia evaporation method for the direct synthesis of ethanol from CO hydrogenation. The catalyst exhibited the initial ethanol selectivity as high as 40.0 wt %, which dramatically decreased from 40.0 to 9.6 wt % on the stream of 50 h. XRD, XPS, TEM and N2O titration techniques were employed to elucidate the ethanol selectivity change and catalyst structure evolution during reaction process. The experiment and characterization results indicated that both Cu+/(Cu++Cu0) value and copper crystallite size had great effects on the ethanol selectivity. During the initial 38 h, the ethanol selectivity obviously decreased from 40.0 to 18.2 wt %, and Cu+/(Cu++Cu0) value on the catalyst surface rapidly dropped from 0.67 to 0.39, while the copper crystallite size remained almost unchanged. However, during the reaction period of 38–50 h, the Cu+/(Cu++Cu0) value possessed no distinct change, but a further decrease in ethanol selectivity and a rapid aggregation in Cu particles were observed simultaneously. The present systematic investigation demonstrated that the decrease of Cu+/(Cu++Cu0) value was the main factor for the loss of ethanol selectivity during the initial 38 h, whereas the rapid growth of Cu particles during the reaction period of 38–50 h were mainly contributed to the further decline of ethanol selectivity.
The Rise of Catalyst Informatics: Towards Catalyst Genomics
Authors: Takahashi Keisuke , Takahashi Lauren , Miyazato Itsuki , Fujima Jun , Tanaka Yuzuru , Uno Takeaki , Satoh Hiroko , Ohno Koichi , Nishida Mayumi , Hirai Kenji , Ohyama Junya , Nguyen Thanh Nhat , Nishimura Shun , Taniike Toshiaki 
Published: December 2018

AbstractCatalysis research is on the verge of experiencing a paradigm shift regarding how catalysts are designed and characterized due to the rise of catalyst informatics. The details of catalyst informatics are reviewed where the following three key concepts are proposed: catalyst data, catalyst data to catalyst design via data science, and catalyst platform. Additionally, progress and opportunities within catalyst informatics are explored and introduced. If the field of catalyst informatics grows in the appropriate manner, the methods and approaches taken for catalyst design would be fundamentally altered, leading towards great advancement within catalysis research.
Continuous‐Flow Pd‐Catalyzed Carbonylation of Aryl Chlorides with Carbon Monoxide at Elevated Temperature and Pressure
Authors: Mata Alejandro , Hone Christopher A. , Gutmann Bernhard , Moens Luc , Kappe C. Oliver 
Published: December 2018

AbstractThe development of a continuous‐flow protocol for a palladium‐catalyzed methoxycarbonylation of (hetero)aryl chlorides using carbon monoxide gas and methanol is described. (Hetero)aryl chlorides are the least expensive of the aryl halides, but are underutilized in carbonylation reactions due to their very poor reactivity. The described protocol exploits intensified conditions at elevated temperature and pressure, which are readily accessed within a continuous‐flow environment, to provide moderate to excellent product yields (11 examples) in a short 16 min residence time. The continuous‐flow protocol enables the safe and potentially scalable carbonylation of aryl chlorides using CO gas.
Complex Phase Behaviour and Structural Transformations of Metal‐Organic Frameworks with Mixed Rigid and Flexible Bridging Ligands
Authors: Arkawazi Hayder D. J. , Clowes Rob , Cooper Andrew I. , Konno Takumi , Kuwamura Naoto , Pask Christopher M. , Hardie Michaele J. 
Published: December 2018

AbstractTwo new heteroleptic metal‐organic framework materials show strong adsorption of H2 and ethanol. [Co2(L1)(bdc)2], where L1=N1,N4‐bis(4‐pyridinylmethyl)‐2,5‐dimethylbenzene‐1,4‐diamine and bdc is benzene‐1,4‐dicarboxylate, has a twofold interpenetrating pillared layer structure with pcu topology. It has a stepped, hysteretic EtOH adsorption that can be related to complicated phase and structural transformation behaviour that occurs on de‐solvation and re‐solvation, including major conformational changes to the geometry of the flexible L1 ligand. [Co2(L1)(bpdc)2], where bpdc=biphenyl‐4,4′‐dicarboxylate, has a unique six‐connected self‐catenating framework structure. Solvation changes occur without significant structural change and a partially‐hydrolysed material binds its own decomposition products as guests.
Thermal and Photophysical Properties of Highly Quadrupolar Liquid‐Crystalline Derivatives of the [closo‐B12H12]2− Anion
Authors: Ali Muhammad O. , Lasseter John C. , Żurawiński Remigiusz , Pietrzak Anna , Pecyna Jacek , Wojciechowski Jakub , Friedli Andrienne C. , Pociecha Damian , Kaszyński Piotr 
Published: December 2018

AbstractTwo series of 1,12‐bis‐zwitterionic derivatives of the [closo‐B12H12]2− anion (B), containing either two 4‐alkoxypyridinium groups (1B[n]‐p) or one 4‐alkoxypyridinium and one 4‐pentylthianium groups (2B[n]‐p), were prepared and their structural (XRD, DFT), thermal, and photophysical properties were compared with those of the analogous derivatives of the [closo‐B10H10]2− anion (1A[n]‐p and 2A[n]‐p). Some 1,7‐derivatives of B were isolated and investigated. Both series 1[n] and 2[n] exhibit nematic and crystalline polymorphism; the 12‐vertex derivatives (B) have higher transition temperatures than those of the 10‐vertex analogues (A). All compounds fluoresce with quantum yields higher for 1B (ΦF=0.37 for 1B[7]‐p and ΦF=0.27 for 2B[7]‐p) than those for the 10‐vertex analogues (ΦF=0.04 for 2A[5]‐p). DFT calculations demonstrate an order of magnitude lower first hyperpolarizability, β(−ω,ω,0), for 2B[7]‐p than that for the 10‐vertex analogue 2A[7]‐p (1.7×10−30 vs. 18.9×10−30 esu at ω=0).
Electronic Coupling and Electron Transfer between Two Mo2 Units through meta‐ and para‐Phenylene Bridges
Authors: Gao Hang , Mallick Suman , Cao Lijiu , Meng Miao , Cheng Tao , Chen Huo Wen , Liu Chun Y. 
Published: December 2018

AbstractA series of three Mo2 dimers bridged by a meta‐phenylene group has been studied in terms of electronic coupling (EC) and electron transfer (ET) in comparison with the para isomers. Optical analyses on the mixed‐valence complexes indicate that by replacing a para‐phenylene bridge with a meta one, the EC between the two Mo2 centers is dramatically weakened; consequently, the ET rates (ket) are lowered by two to three orders of magnitude. In the para series, the EC parameters (Hab) and ET rates (ket) are greatly affected by O/S atomic alternation of the bridging ligand. However, for the meta analogues, similar EC and ET parameters are obtained, that is, Hab=300–400 cm−1 and ket≈109 s−1. These results suggest that through‐σ‐bond and/or through‐space coupling channels become operative as the π conjugation is disabled. DFT calculations reveal that destructive quantum interference features seen for the meta series arise from the cancellation of two π‐conjugated coupling pathways.
Microtubule‐Targeting 7‐Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multidrug‐Resistance Proteins
Authors: Dasari Ramesh , Błauż Andrzej , Medellin Derek C. , Kassim Roaa M. , Viera Carlos , Santarosa Maximo , van der Westhuyzen Alet E. , van Otterlo Willem A. L. , Olivas Taryn , Yildiz Tugba , Betancourt Tania , Shuster Charles B. , Rogelj Snezna , Rychlik Błażej , Hudnall Todd , Frolova Liliya V. , Kornienko Alexander 
Published: December 2018

AbstractOur laboratories have been investigating synthetic analogues of marine alkaloid rigidins that possess promising anticancer activities. These analogues, based on the 7‐deazahypoxanthine skeleton, are available in one‐ or two‐step synthetic sequences and exert cytotoxicity by disrupting microtubule dynamics in cancer cells. In the present work we extended the available structure–activity relationship (SAR) data to N3‐ and N9‐substituted derivatives. Although N3 substitution results in loss of activity, the N9‐substituted compounds retain nanomolar antiproliferative activities and the anti‐tubulin mode of action of the original unsubstituted compounds. Furthermore, our results also demonstrate that multidrug‐resistance (MDR) proteins do not confer resistance to both N9‐unsubstituted and ‐substituted compounds. It was found that sublines overexpressing ABCG2, ABCC1, and ABCB1 proteins are as responsive to the rigidin analogues as their parental cell lines. Thus, the study reported herein provides further impetus to investigate the rigidin‐inspired 7‐deazahypoxanthines as promising anticancer agents.