bluuebunny/crossref_metadata_2025_split huggingface dataset:
Getting the Word Out, Rain or Shine: The Impact of Message Features and Hazard Context on Message Passing Online
Authors: Sutton Jeannette , Renshaw Scott L. , Vos Sarah C. , Olson Michele K. , Prestley Robert , Ben Gibson C. , Butts Carter T. 
Published: June 2019

AbstractNetworked social media provide governmental organizations, such as the National Weather Service (NWS), the opportunity to communicate directly with stakeholders over long periods of time as a form of online engagement. Typologies of engagement include aspects of message content that provide information, contribute to community building, and inspire action and aspects of message microstructural features that facilitate interaction and dialogue, such as directed messages, hashtags, and URLs. Currently, little is known regarding the effect of message strategies on behavioral outcomes, and whether those effects vary under different weather conditions. In this paper we examine how message practices used on Twitter by the NWS are related to message engagement under routine and nonroutine weather conditions. Our analysis employs a census of tweets sent by 12 NWS Weather Forecast Offices in spring 2016 and uses a combination of manual and automated coding to identify engagement content and microstructure features present in each message. We identify factors that increase and decrease message retransmission (retweets) within this corpus under varying threat conditions, using a mixed-effects negative binomial regression model. We find that inclusion of actionable message content, information about historical weather facts, attached visual imagery (such as a map or infograph), and named event hashtags increases message passing during both threat and nonthreat periods. In contrast, messages that include forecast and nowcast content and messages that are sent in reply to other users have a lower passing rate. Findings suggest that common message features do alter message passing, potentially informing message design practices aimed at increasing the reach of messages sent under threat conditions.
Response Complexity Reduces Errors on a Response Inhibition Task
Authors: Head James , Tenan Matthew S. , Tweedell Andrew J. , Wilson Kyle M. , Helton William S. 
Published: June 2019

Objective The purpose of this investigation was to elucidate the role of button-response complexity to targets in a response inhibition task. Background Response inhibition is the ability to correctly inhibit an overt response to a target. The U.S. military is actively pursuing development of armed, combat robots as a force multiplier, which may present challenges to operators of combat robots in the form of response inhibition errors. Method A total of 15 participants completed two 51-min versions of a modified sustained attention to response task (SART). Participants were outfitted with an electrocardiogram to index heart-rate variability and completed the NASA–Task Load Index (NASA-TLX) to index workload. Results The results demonstrated that the complex SART reduced errors of commission (4%) and slowed response times (874 ms) to correct Go targets relative to the simple SART (14%, 739 ms). The NASA-TLX did not show differences between the modified SARTs; however, heart-rate variability did demonstrate that Soldiers had an increased autonomic stress response to the complex SART. Conclusion Increasing the behavioral response requirement during a response inhibition task can decrease errors of commission; however, it comes at the cost of slower response times to target stimuli. Heart-rate variability may provide better insight into objective workload relative to subjective measures. Application The use of complex behavioral responses may provide a viable option to reduce potential “friendly fire” or collateral damage by Soldiers remotely engaging a target-rich environment.
Employee involvement in the public administrative sector: an exploration of the engagement drivers in Cameroon
Authors: Tioumagneng André , Njifen Issofou 
Published: June 2019

In many developing countries, despite the efforts made to roll out New Public Management, public service quality is still more of an ideal than a reality. Employee disengagement emerges time and again in reflections on the causes of the problem, without, in most contexts, having any precise explanations. The article sets out to identify the engagement drivers likely to secure the effective involvement of public officials tasked with providing the public administrative service. To do this, an empirical study is conducted in Cameroon. The analysis makes use of both statistical inference and content analysis. Its results tell us that the involvement of public officials is linked, in particular, to work organisation, human resources management practices and the recognition of their potential by their superiors. Points for practitioners This study identifies some major current issues. For anyone involved in human resources management, work involvement is a competitive tool that creates value. It is considered as one of the general objectives that staff management practices should help to achieve. A high-quality public service requires particular attention to be granted to work involvement. The study reveals many employee engagement drivers that can boost the performance of public administrations, particularly in developing countries.
Effect of subsurface pressure on the interface pressure measurement in an in vitro experiment
Authors: Chi Yung-Wei , Lin Ray , Tseng Kuo-Hao , Durbin-Johnson Blythe 
Published: June 2019

Introduction It was hypothesized that subsurface pressure (mimicking subcutaneous pressure) variation may affect interface pressure measurement. Method BISCO® (Rogers, CT) foam was placed on a cylinder cuff model for the experiment. Picopress® and a piezoresistive sensor were used for interface pressure measurement. External pressure was applied using an automated pressure cuff at 40 mmHg. Subsurface pressure mimicking subcutaneous pressure from 3 mmHg to 12 mmHg was generated by a pressure pump underneath the foam. Interface pressure was compared between the true pressure, 40 mmHg, versus Picopress® and the piezoresistive sensor using linear mixed effect model (SAS software, version 9.4, SAS Institute, Cary, NC). Result Interface pressure measurement using Picopress® did not differ between the incremental subsurface pressures (mean 45.4 ± 0.4) ( P = 0.54), in contrast to piezoresistive sensor, which demonstrated a difference (mean 42.65 ± 2.7) ( P < 0.001). This difference appeared to be linearly related. Conclusion Subsurface pressure mimicking subcutaneous pressure may affect the overall interface pressure measurement according to the piezoresistive sensor but not Picopress®.
A study validating the Italian version of the Level of Sitting Scale in children with cerebral palsy
Authors: Tofani Marco , Candeloro Costanza , Sabbadini Maurizio , Field Debra , Frascarelli Flaminia , Lucibello Luca , Valente Donatella , Galeoto Giovanni , Castelli Enrico 
Published: June 2019

Objectives: To assess measurement properties of the Italian version of the Level of Sitting Scale when classifying sitting ability of children with cerebral palsy. Design: Methodological study. Setting: Children’s hospital (inpatients and outpatients). Subjects: Children 18 years of age or younger with cerebral palsy. Methods: The original English version of the Level of Sitting Scale was translated and culturally adapted for the Italian culture following international guidelines. Examination of reliability and validity of the Italian Level of Sitting Scale was then undertaken. Inter-rater and one-week test–retest reliability were estimated using both intraclass correlation coefficients (ICCs) with 95% confidence intervals and Bland–Altman plots. Construct validity of the Italian Level of Sitting was evaluated using three approaches examining Pearson’s correlation coefficient ( r) and Mann–Whitney U test ( P-value < 0.05). Main measures: Italian Level of Sitting Scale and Gross Motor Function Classification System. Results: The Italian Level of Sitting Scale was administered to 109 subjects. Inter-rater reliability and one-week test–retest showed excellent value with ICCs of 0.99 for both. (1) The Pearson correlation coefficient comparing Italian Level of Sitting Scale with Gross Motor Function Classification System was −0.91 and (2) correlation with total amount of adaptive seating components was −0.90. Differences in sitting abilities and use/non-use of wheelchair were found. All reported a statistical significance of P < 0.01. Conclusion: Our findings provide evidence of reliability and validity when using the Italian Level of Sitting Scale to classify seated postural abilities in a sample of Italian children with cerebral palsy.
Tumor necrosis factor-related apoptosis-inducing ligand modulates angiogenesis and apoptosis to inhibit non-small cell lung carcinoma tumor growth in mice
Authors: Chen Yuanmei , Xu Yuanji , Zhu Kunshou , Cao Zhiyun , Huang Zhengrong 
Published: June 2019

Objective To investigate the anti-tumor effect and mechanism of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in non-small cell lung carcinoma (NSCLC) in mice. Methods We first established NSCLC animal models using 20 BALB/c nude mice that were randomly divided into two equal groups (n = 10): TRAIL-treated and control untreated groups. We measured expression levels of B cell leukemia/lymphoma-2 (Bcl-2), Bcl-2-associated X protein (Bax), vascular endothelial growth factor (VEGF), and VEGF receptor (VEGFR). We also performed microvessel density, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL), and immunohistochemical assays to determine the effect of TRAIL on apoptosis and angiogenesis in NSCLC tumors in vitro. Results TRAIL inhibited tumor growth in the NSCLC mouse model, and the TUNEL assay showed that it induced tumor cell apoptosis. Immunohistochemical staining revealed that TRAIL induced Bcl-2 protein downregulation, suggesting that the mitochondrial apoptotic pathway is involved in regulating NSCLC apoptosis. However, TRAIL did not affect Bax protein expression. Immunohistochemical staining also revealed significantly reduced VEGF and VEGFR protein expression in the TRAIL group, indicating that TRAIL limits angiogenesis in NSCLC tumor tissues. Conclusions In conclusion, TRAIL inhibits NSCLC growth both by inducing tumor cell apoptosis and restricting angiogenesis in tumors.
Impact of prior statin use on mortality in patients with type 2 diabetes mellitus and bloodstream infection
Authors: Cheng Chi-Yung , Kung Chia-Te , Chen Fu-Cheng , Cheng Hsien-Hung , Tsai Tsung-Cheng , Hsiao Sheng-Yuan , Su Chih-Min 
Published: June 2019

Objective This study assessed the effect of prior statin use on the 28-day mortality of patients with type 2 diabetes mellitus (DM) who develop bloodstream infections. Methods This retrospective cohort study included all adult type 2 DM patients with bacteremia and verified prior medication history who visited the emergency department of a single tertiary hospital between January 2007 and December 2013. All major adverse consequences including septic shock events, use of mechanical ventilation, intensive care unit admission, and 28-day mortality were assessed. Results A total of 1,979 patients were enrolled in the study, of whom 507 were taking statins. Statin users had less severe disease presentation and lower levels of sepsis biomarkers such as bandemia (1.3 ± 3.1 vs 1.8 ± 4.2). After adjustment for confounding variables using a Cox regression model, only older age (adjusted hazard ratio [HR]: 1.04, 95% confidence interval [CI], 1.01–1.04), urinary tract infection (adjusted HR: 0.56, 95% CI, 0.43–0.75), and prior statin use (adjusted HR: 0.58, 95% CI: 0.42–0.85) were significantly associated with 28-day in-hospital mortality. Conclusion Prior statin treatment in patients with type 2 DM and bacteremia was associated with a lower 28-day in-hospital mortality rate.
Aptamer-Functionalized Bioscaffold Enhances Cartilage Repair by Improving Stem Cell Recruitment in Osteochondral Defects of Rabbit Knees
Authors: Wang Xin , Song Xiongbo , Li Tao , Chen Jiajia , Cheng Guotao , Yang Liu , Chen Cheng 
Published: June 2019

Background: Recruitment of endogenous stem cells has been considered an alternative to cell injection/implantation in articular cartilage repair. Purpose: (1) To develop a cartilage tissue-engineering scaffold with clinically available biomaterials and functionalize the scaffold with an aptamer (Apt19s) that specifically recognizes pluripotent stem cells. (2) To determine whether this scaffold could recruit joint-resident mesenchymal stem cells (MSCs) when implanted into an osteochondral defect in a rabbit model and to examine the effects of cartilage regeneration. Study Design: Controlled laboratory study. Methods: The reinforced scaffold was fabricated by embedding a silk fibroin sponge into silk fibroin/hyaluronic acid–tyramine hydrogel and characterized in vitro. A cylindrical osteochondral defect (3.2 mm wide × 4 mm deep) was created in the trochlear grooves of rabbit knees. The rabbits were randomly assigned into 3 groups: Apt19s-functionalized scaffold group, scaffold-only group, and control group. Animals were sacrificed at 6 and 12 weeks after transplantation. Repaired tissues were evaluated via gross examination, histologic examination, and immunohistochemistry. Results: In vitro, this aptamer-functionalized scaffold could recruit bone marrow–derived MSCs and support cell adhesion. In vivo, the aptamer-functionalized scaffold enhanced cell homing in comparison with the aptamer-free scaffold. The aptamer-functionalized scaffold group also exhibited superior cartilage restoration when compared with the scaffold-only group and the control group. Conclusion: The Apt19s-functionalized scaffold exhibited the ability to recruit MSCs both in vitro and in vivo and achieved a better outcome of cartilage repair than the scaffold only or control in an osteochondral defect model. Clinical Relevance: The findings demonstrate a promising strategy of using aptamer-functionalized bioscaffolds for restoration of chondral/osteochondral defects via aptamer-introduced homing of MSCs.
Chronic pain in cats: Recent advances in clinical assessment
Authors: Monteiro Beatriz P , Steagall Paulo V 
Published: June 2019

Practical relevance: Chronic pain is a feline health and welfare issue. It has a negative impact on quality of life and impairs the owner–cat bond. Chronic pain can exist by itself or may be associated with disease and/or injury, including osteoarthritis (OA), cancer, and oral and periodontal disease, among others. Clinical challenges: Chronic pain assessment is a fundamental part of feline practice, but can be challenging due to differences in pain mechanisms underlying different conditions, and the cat’s natural behavior. It relies mostly on owner-assessed behavioral changes and time-consuming veterinary consultations. Beyond OA – for which disease-specific clinical signs have been described – little is known regarding other feline conditions that produce chronic pain. Recent advances: Knowledge of the subject has, however, greatly improved in the past few years, informed by study of the mechanisms of pain in cats with OA and the development of pain scales that can be used by owners or veterinarians. Pain scales may facilitate the diagnosis and follow-up evaluation of chronic painful conditions, providing a basis for therapeutic decision-making. Assessment of quality of life is also recommended in cats with chronic pain, and its improvement can be used as a positive outcome in response to therapy. Aims: This article reviews recent advances and presents the challenges and some future perspectives on clinical chronic pain assessment. The most common feline chronic conditions associated with pain are also described.
T cells producing GM-CSF and IL-13 are enriched in the cerebrospinal fluid of relapsing MS patients
Authors: Ghezzi Laura , Cantoni Claudia , Cignarella Francesca , Bollman Bryan , Cross Anne H , Salter Amber , Galimberti Daniela , Cella Marina , Piccio Laura 
Published: June 2019

Background: Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune demyelinating disease. Its pathogenesis involves humoral and cellular immunity, with production of pro- and anti-inflammatory cytokines by T cells. Objective: To analyze the cytokine profile of cerebrospinal fluid (CSF) T cells in patients with relapsing-remitting MS (RRMS) and non-inflammatory controls. Methods: T cell cytokine production was analyzed by flow cytometry in CSF samples collected from 34 untreated RRMS patients and 20 age-matched controls. Immunofluorescence studies were performed in spinal cord MS active lesions. Results: Percentages of CSF-derived IL-17A, IL-17A/IL-22, and IL-17A/GM-CSF producing T cells were significantly higher in RRMS patients compared to controls. Percentages of T cells producing IFN-γ were lower in RRMS patients compared to controls. Patients in relapse showed higher percentages of CD4+ T cells producing IL-13 and GM-CSF compared to patients in remission. We found a positive correlation between percentages of IL-13+ T cells and the Expanded Disability Status Scale (EDSS; ρ = 0.5; p < 0.05). Meningeal IL-13-producing T cells were detected in spinal cord MS active lesions. Conclusion: We observed differences in IL-17, IL-22, and IFN-γ production by CSF T cells in RRMS versus controls and a positive correlation between IL-13-producing T cells and EDSS in RRMS patients.
Air-fluctuation nozzle and its periodic, wave-like air distribution evaluation
Authors: Hou Yicun , Li Angui , Zhang Ying 
Published: June 2019

In order to investigate dynamic characteristics of fluctuating air, one kind of nozzles of producing periodical fluctuating air is presented in this paper. Assume that the jet is isothermal and free, the typical parameters of the airflow characteristics, such as the maximum jet velocity decay, the non-dimensional velocity profile on different sections and the turbulence intensity have been discussed. In addition, power spectrum density of experimental data was calculated and analysed. The result shows that compared with stable air supply, the fluctuating air velocity decay is slower, thus forming a more uniform velocity field. Furthermore, turbulence intensity of the fluctuating air is larger. The power spectrum density exponent value approaches to the value of typical natural wind when the air velocity decreases to 0.6 m/s. With airflow diffusion, the fluctuation characteristic of airflow changes to that of natural wind gradually.
Informal caregivers in stroke: Life impact, support, and psychological well-being—A Swedish Stroke Register (Riksstroke) study
Authors: Sennfält Stefan , Ullberg Teresa 
Published: June 2019

Background Informal caregivers provide a large amount of day-to-day assistance and are crucial for the ability of survivors to recover and adapt to life after stroke. Aim The development of caregiver support programs is limited by lack of large long-term follow-up studies. We present a comprehensive study of Swedish stroke caregivers' life situation in relation to degree of functional dependency of the survivor. Patients and methods In 2016, the Swedish Stroke Register, Riksstroke, conducted a long-term follow-up survey on caregivers to patients with stroke three and five years earlier. Items on psychological well-being were adapted from the 36-item short-form health survey and poor outcome was defined using the 36-item short-form health survey reference material. Survivor degree of dependency was indicated by the caregiver as independent, partially dependent, or completely dependent. Results A total of 5063 community dwelling dyads were included: 56.5% of survivors were independent, 33.4% partially dependent, and 10.1% completely dependent. Caregiver life impact, need of support, and proportion of poor psychological well-being increased incrementally with survivor degree of dependency. In the completely dependent group where 41.1% of survivors could not be left unattended for more than 1 h, 23.7% of caregivers expressed unmet need of caregiver support; 51.4% reported poor psychological well-being compared to 19.3% in the independent group. Conclusion The caregiver situation varies greatly with degree of survivor dependency which makes generalizations of caregiver needs difficult. Our results emphasize the need for integrating support aimed specifically at caregivers to survivors of stroke with a large degree of dependency.
Quality Appraisal of Child Oral Health–Related Quality of Life Measures: A Scoping Review
Authors: Yang C. , Crystal Y.O. , Ruff R.R. , Veitz-Keenan A. , McGowan R.C. , Niederman R. 
Published: June 2019

Background: Children’s oral health–related quality of life (COHQoL) measures are well known and widely used. However, rigorous systematic reviews of these measures and analyses of their quality are in absence. Objectives: To systematically review and quantitatively assess the quality of COHQoL measures through a scoping review. Data Sources: Systematic literature search of PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), EMBASE (Excerpta Medica database), HaPI (Health and Psychosocial Instruments), and DOSS (Dentistry and Oral Sciences Source). Study Eligibility: The measure’s focus was COHQoL; the child age ranged from 5 to 14 years; the publication was either a research article or a systematic review and related to caries; and it was written in English or had an English abstract. Two authors independently selected the studies. Disagreements were reconciled by group discussions with a third author. Appraisal: The International Society for Quality of Life Research minimum standards for patient-reported outcome measures were used for quality appraisal. Synthesis: Descriptive analysis. Results: We identified 18 measures. Their quality scores ranged from 9.5 to 15.0 on a scale of 16. The quality appeared to bear no relationship to the citation and use of these measures. However, elements of these measures might be more useful than others, depending on the age-specific use and primary quality concerns. Limitations: Some of the information on the minimum standards of the 18 measures cannot be found in the existing literature. Measures published without English abstract were not searched. Conclusions: The quality of these measures is suboptimal. Researchers and practitioners in this field should exercise caution when choosing and using these measures. Efforts at improving the quality of the COHQoL measures, such as refining existing ones or developing new measures, are warranted. Knowledge Transfer Statement: Researchers, clinician scientists, and clinicians can use the results of this study when deciding which oral health–related quality of life measure they wish to use in children.