bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’Activité Fibrinolytique dans les Endocardites Subaiguës
Authors: Scrobohaci Dr. Marie-Lorraine , Stancioiu Dr. N , Orha Dr. I 
Published: July 2018

RésuméLes auteurs ont étudié l’activité fibrinolytique chez 50 malades valvulaires, dont 30 malades avec ERR et 20 avec EBS, dans le but de tirer au clair quelques aspects moins explorés de la thrombogénèse.L’activité fibrinolytique a été étudiée par determination des activateurs et des antiactivateurs de l’urokinase et de la streptokinase.Les résultats mettent en évidence une diminution de l’activité fibrinolytique tant pour ERR que pour EBS, l’inhibition prédominant dans cette dernière affection.Le taux des antiactivateurs de la fibrinolyse est augmenté tant pour ERR que pour EBS, mais davantage pour ERR. Les mécanismes de diminution de l’activité fibrinolytique diffèrent dans les deux maladies : pour ERR elle est due probablement à l’excès des antiactivateurs de la fibrinolyse, mais pour EBS à la déficience des activateurs.Les auteurs attirent l’attention sur le fait que ce comportement différent des activateurs de la fibrinolyse pourrait constituer un indice de la réactivité différente dans les deux maladies dans le sens de l’hyperergie pour ERR et de l’hypoanergie pour en EBS. La tendance thrombophilique variable pour chaque maladie pourrait être une conséquence de la modification immunobiologique spécifique.
Der Einfluß von Gift der Sandrasselotter (Echis carinata) auf die Hämostase
Authors: Zimmermann Heide , Habermann E , Lasch H.-G 
Published: July 2018

ZusammenfassungEchis carinata-Gift und die daraus gewonnene gerinnungsfördernde Fraktion (»Coagulase«) führen zu einer Aktivierung des Prothrombinkomplexes. Die initiale Phase der Gerinnungsaktivierung geht in eine Phase der Hypokoagulabilität über. Sowohl der Abfall der Faktoren I, II, V, VIII, XIII, des Thrombozyten und des Antithrombin III als auch der Nachweis von Kryofibrinogen und Fibrinmonomer sind ein Beweis für intravaskulär entstandenes Thrombin. Diese im Sinne einer »Verbrauchs - koagulopathie« zu deutenden gerinnungsphysiologischen Veränderungen werden in ihrer Wirkung auf den Organismus (Steigerung der Letalität) durch gleichzeitige Norepinephringabe oder RES-Blockade verstärkt und können durch Vorbehandlung der Tiere mit Marcumar verhindert werden.
Purification of Streptokinase and Human Plasmin and Their Interaction
Authors: Blatt W. F , Segal H , Gray J. L 
Published: July 2018

SummaryProcedures have been described for the purification of streptokinase and human plasmin, and molecular weights of 42,600 and 88,800 respectively have been determined. Equilibration of streptokinase with plasmin solutions produced an inhibition of caseinolytic activity and indicated a mole-mole interaction. This inhibitory activity was lost following acid treatment. When these data are considered with the previously reported findings using plasminstreptokinase mixtures as plasminogen activators, it would appear that plasmin and streptokinase react to form a complex which has the ability to convert both human and bovine plasminogen to plasmin.
Studies on Tissue Thromboplastin II. Species Specificity*)
Authors: Irsigler K , Lechner K , Deutsch E ,   with the technical assistence of H. Lomoschitz
Published: July 2018

Summary1. Purified brain tissue thromboplastins of human, bovine and chicken origin have been tested on homologous and heterologous plasmas.2. Purified brain tissue thromboplastin is species specific.3. Lipid extracts from purified brain tissue thromboplastin prepared with pyridin show a negligable residual species specificity, probably caused by a slight contamination with brain tissue thromboplastin.4. The activity curves of our lipid extracts differ from typical curves expected for lipid activators by a less distinct inhibition in high concentrations probably caused by a different composition of petrol-ether and pyridin extracts.5. The protein part of tissue thromboplastin does not activate prothrombin in any system.6. The protein part of tissue thromboplastin of one species could be combined with the lipid part of another species to form an active tissue thromboplastin.7. The species specificity of these combinations was determined by the source of protein used.
Neutralization of Antithrombin VI (Fibrinogen Breakdown Products) with Platelet Antiheparin Factor (Platelet Factor 4)*
Authors: Niewiarowski S , Farbiszewski R , Popławski A 
Published: July 2018

SummaryIt has been found that fibrinogen breakdown product – antithrombin VI – is neutralized by the purified preparation of platelet factor 4, obtained by means of zinc acetate precipitation and DEAE chromatography column. It has been suggested that antiheparin activity of platelet factor 4 and its ability to neutralize antithrombin VI may be related to the same protein.The purified preparation of platelet factor 4 does not influence the fibrinogen – fibrin conversion by thrombin. This means that platelet factor 2 and platelet factor 4 are not the same substance.Crude platelet extracts neutralize antithrombin III and V. However, the purified product did not interferes with the action of these antithrombins.
A One-stage Factor VIII (Antihaemophilic Globulin) Assay and its Use on Venous and Capillary Plasma
Authors: Hardisty R. M , Macpherson Janet C. ,   Note on the Calculation of Confidence Limits by G. I. C. Ingram
Published: July 2018

SummaryA one-stage factor-VIII assay is described, based on the method of Lang-dell, Wagner and Brinkhous (1953), in which contact activation is controlled by the addition of a suspension of kaolin to the system. Experiments to show the effect of this modification on the clotting times and reproducibility of the system are presented.The error of the method is expressed in terms of the confidence limits of a random series of field assays, which lay between 64—156% and 76—131% of the observed result.The normal range of factor-VIII concentrations, as determined by this method on venous plasma samples from 116 normal subjects, was 50—170%, with a roughly normal distribution. There was good correlation between the results of one-stage and two-stage factor-VIII assays carried out in parallel on 110 plasma samples and between the observed and expected factor-VIII concentrations of a series of mixtures of normal and haemophilic plasma.The use of the assay on capillary plasma samples is described, and the results compared with those obtained on venous plasma. The practical value of capillary factor-VIII assays is discussed.
Der Mechanismus des sogenannten »Heparin-Rebound« nach extrakorporellem Kreislauf
Authors: Brögli H 
Published: July 2018

ZusammenfassungDas sogenannte »Heparin-Rebound«-Phänomen nach extrakorporellem Kreislauf ist die Folge einer Inaktivierung des Protamins. Die Protaminstabili-tät ist präparatabhängig und variiert von Patient zu Patient. Protaminchlorid verhält sich im Plasma weitgehend stabil, während Protaminsulfat rasch inaktiviert wird. Es wird gezeigt, daß bei unstabilen Protaminpräparaten trotz initial vollständiger Heparinneutralisation sowohl in vivo als auch in vitro ein Heparineffekt wieder in Erscheinung tritt. Die Protamininstabilität im Plasma ist temperaturabhängig und wird durch einen hitzelabilen Plasmafaktor verursacht. Im Plasma bei 4° 0, in hitzedenaturiertem Plasma oder in Puffer bei 37° C inkubiert bleibt der Heparin-Protamin-Komplex stabil.
Coagulation Dynamics in Factor V Deficiency: A Family Study, with a Note on the Occurrence of Thrombophlebitis, ,
Authors: Miller Sherwood P. ,   with the technical assistance of Joanna Siggerud and Tadeusz Stefanski, B. S.
Published: July 2018

Summary1. A family with congenital proaccelerin (factor V) deficiency is here reported. The mode of inheritance appears to be by means of an autosomal recessive gene. The homozygous propositus (proaccelerin less than 2% of normal) had a life-long, moderately severe, bleeding tendency. The heterozygotes (proaccelerin 45 to 66%) were clinically normal.2. Studies on the rate of consumption of coagulation factors during blood clotting revealed normal consumption of antihemophilic globulin (factor VIII), but defective consumption of prothrombin (II) in the propositus. This indicated the entry of proaccelerin into the clotting process between the stages at which antihemophilic globulin and prothrombin are involved. Five of the seven heterozygotes studied showed a similar pattern. These findings are consistent with current theories of the role of proaccelerin in the normal sequence of events in the coagulation scheme.3. The propositus had an episode of thrombosis of the deep saphenous vein which is apparently a unique occurence in the literature of proaccelerin deficiency.
Anticoagulant Activity of β2-Glycoprotein I Is Potentiated by a Distinct Subgroup of Anticardiolipin Antibodies
Authors: Galli Monica , Comfurius Paul , Barbui Tiziano , Zwaal Robert F A , Bevers Edouard M 
Published: July 2018

SummaryPlasmas of 16 patients positive for both IgG anticardiolipin (aCL) antibodies and lupus anticoagulant (LA) antibodies were subjected to adsorption with liposomes containing cardiolipin. In 5 of these plasmas both the anticardiolipin and the anticoagulant activities were co-sedimented with the liposomes in a dose-dependent manner, whereas in the remaining cases only the anticardiolipin activity could be removed by the liposomes, leaving the anticoagulant activity (LA) in the supernatant plasma. aCL antibodies purified from the first 5 plasmas were defined as aCL-type A, while the term aCL-type B was used for antibodies in the other 11 plasmas, from which 2 were selected for this study.Prolongation of the dRVVT was produced by affinity-purified aCL-type A antibodies in plasma of human as well as animal (bovine, rat and goat) origin. aCL-type B antibodies were found to be devoid of anticoagulant activity, while the corresponding supernatants containing LA IgG produced prolongation of the dRVVT only in human plasma.These anticoagulant activities of aCL-type A and of LA IgG's were subsequently evaluated in human plasma depleted of β2-glycoprotein I (β2-GPI), a protein which was previously shown to be essential in the binding of aCL antibodies to anionic phospholipids. Prolongation of the dRVVT by aCL-type A antibodies was abolished using β2-GPI deficient plasma, but could be restored upon addition of β2-GPI. In contrast, LA IgG caused prolongation of the dRVVT irrespective of the presence or absence of β2-GPI.Since β2-GPI binds to negatively-charged phospholipids and impedes the conversion of prothrombin by the factor Xa/Va enzyme complex (Nimpf et al., Biochim Biophys Acta 1986; 884: 142–9), comparison was made of the effect of aCL-type A and aCL-type B antibodies on the rate of thrombin formation in the presence and absence of β2-GPI. This was measured in a system containing highly purified coagulation factors Xa, Va and prothrombin and lipid vesicles composed of 20 mole% phosphatidylserine and 80 mole% phosphatidylcholine. No inhibition on the rate of thrombin formation was observed with both types of aCL antibodies when either β2-GPI or the lipid vesicles were omitted. Addition of β2-GPI to the prothrombinase assay in the presence of lipid vesicles causes a time-dependent inhibition which was not affected by the presence of aCL-type B or non-specific IgG. In contrast, the presence of aCL-type A antibodies dramatically increased the anticoagulant effect of β2-GPI. These data indicate that the anticoagulant activity of aCL-type A antibodies in plasma is mediated by β2-GPI.
Tumor renal benigno versus carcinoma renal: reporte de caso y revisión de la literatura
Authors: Salinas Perdomo Jorge , Luna Meza Ángela , Castañeda-Cardona Camilo , Rosselli Diego 
Published: July 2018

Introducción El cáncer renal representa 2,4% de los casos diagnosticados de cáncer en la población general, es más común en hombres que en mujeres, y se presenta con más frecuencia entre la 6ta y la 8ta décadas de vida. Se estima que el 16% de los pacientes se diagnostican como enfermedad metastásica.
Objetivo Se presenta el caso de un paciente cuyo diagnóstico de carcinoma renal se confundió inicialmente con un tumor benigno.
Métodos A un hombre de 56 años de edad se le realizó hace 3 años ese diagnóstico en un estadio avanzado de la enfermedad, a pesar del hallazgo incidental de una masa, que se consideró benigna durante 5 años.
Resultados Al momento del diagnóstico de carcinoma de células claras, el tumor era Estadio IV, con metástasis a pulmón. Recibió primera línea de tratamiento con sunitinib, pero fue suspendido por toxicidad; segunda línea con pazopanib durante 1 año, después presentó progresión de la enfermedad, por lo cual se cambió a tratamiento con axitinib con respuesta parcial, sin embargo, se suspendió por toxicidad cardiaca, entre otras. Al momento el paciente ha recibido 5 ciclos de bevacizumab con adecuada tolerancia.
Conclusiones Es necesario resaltar la indicación de diagnóstico adecuado y manejo quirúrgico en masas renales sospechosas.
Relevancia del antecedente de absceso perirrenal en pacientes sometidos a nefrectomía simple retroperitoneal
Authors: Carrillo-Córdova Luis , Sarabia-Estrada Roberto , Jiménez-Villavicencio Jean , Vitar-Sandoval Jhonatan , Rivera-Astorga Hugo , Lemus-Mena Gerardo , Sánchez-Meza Eduardo , Carrillo-Córdova Jorge , Camilo-Martínez Eli , Hernandez-Farias Miguel , Rosas-Ramírez Alejandro , Virgen-Gutiérrez José , Jaspersen-Gastelum Jorge , Garduño-Arteaga Mateo 
Published: July 2018

Antecedentes Las infecciones supurativas del riñón y del espacio peri nefrítico son poco comunes. La nefrectomía simple consiste en extraer el riñón contenido dentro de la fascia de Gerota, técnica usada principalmente para padecimientos no malignos del riñón. Ese término puede ser potencialmente engañoso ya que el término “simple” implica que la cirugía para enfermedad benigna, es técnicamente menos desafiante con menos complicaciones en relación a su contra parte: la nefrectomía radical.
Metodología Se analizaron 58 pacientes. Los parámetros demográficos de los pacientes con antecedente de absceso perirrenal, fueron comparados con los pacientes sin antecedente de absceso (Edad, género, peso, localización del lito) variables transoperatorias (tiempo quirúrgico, sangrado transoperatorio) y variables postquirúrgicas (necesidad de terapia intensiva, necesidad de transfusión, infección de herida quirúrgica y días de estancia hospitalaria).
Resultados Los pacientes se dividieron en dos grupos, los que contaban con antecedente de absceso (Grupo 1), y aquellos que no tenían antecedente de absceso (Grupo 2). Se encontraron veinte pacientes con antecedente de absceso (34,55%) y treinta y ocho sin antecedente de absceso (65,6%). Al realizar la comparación entre los dos grupos se encontraron con mayor frecuencia en el grupo diferencias estadísticamente significativas para las variables de tiempo quirúrgico (212 minuto (DE 46,6) vs 130.3 minuto (DE 49)p = 0.0001), días de estancia hospitalaria (8,6 días (DE 4,1) vs 5,6 días (DE 1.9) p = 0.0003), e infección de herida quirúrgica (70% vs 31% p = 0,0008), no existieron diferencias estadísticamente significativas para el sangrado transoperatorio, necesidad de transfusión o necesidad de atención en unidad de cuidados intensivos.
Conclusiones La realización de una nefrectomía retroperitoneal simple abierta secundaria a litiasis en pacientes con antecedente de absceso perirrenal, conlleva a un mayor tiempo quirúrgico, secundario a una mayor dificultad técnica del procedimiento, por la gran cantidad de fibrosis y destrucción de la anatomía producida por el absceso. Los pacientes, también presentan un riesgo aumentado de infección de la herida quirúrgica, lo que conlleva a una mayor estancia hospitalaria y a una mayor inversión de recursos materiales y humanos.
Thermographic Patterns for Real-time Intraoperative Monitoring of Testicular Reperfusion Following Surgical Testicular Detorsion
Authors: Fernandez Nicolas , Lorenzo Armando , Blais Anne-Sophie , Matava Clyde 
Published: July 2018

AbstractA 5-year-old patient presents to the emergency department with testicular torsion. Intraoperative sequential infrared thermographic images were registered in real-time using a FLIR One (FLIR Systems, Inc., Wilsonville, OR, US) infrared camera. The temperatures of the scrotum and the testis prior to scrotal exploration were 43.6°C on the affected side, and 41.7°C on the contralateral side. The core temperature of the patient was 36.8°C. Immediately after the tunica vaginalis had been opened and the testis had been brought out through the incision, the temperature of the testicle was 31.5°C. After 30 seconds of being detorted, the temperature increased to 34.3°C. The use of intraoperative infrared thermographic imaging helps to detect discrete changes in testicular temperature, which suggests it may be useful to objectively assess reperfusion. Future studies will require more patients to correlate postoperative blood flow to the injured testis as well as volume changes after surgery to see if the intraoperative thermography findings can be used as a predictive tool for postoperative outcomes.
Indikationen zur Thrombolyse im Kindesalter
Authors: Mentzer D. , Becker Sabine , Kreuz W. 
Published: July 2018

ZusammenfassungDie steigende Anzahl von thrombotischen Ereignissen im Kindesalter, auch bedingt durch die zunehmenden Katheterisierungen in Neonatologie, Kardiologie und Onkologie, zeigen die Bedeutung und Notwendigkeit thrombolytischer Therapien im Kindesalter. Die Indikationsstellung zu einer thrombolytischen Therapie hängt ab von der Lokalisation des Verschlusses sowie den Zielen und möglichen Folgen einer Thrombolyse. Für die Anwendung der Thrombolytika Streptokinase und Urokinase bei Erwachsenen liegen Richtlinien vor, aus denen die Indikationen eindeutig hervorgehen. Im Kindesalter existieren inzwischen zahlreiche Erfahrungen mit der Lysetherapie, jedoch gibt es keine offiziell erstellten Indikationen für diese Therapie. Daher muß bei Kindern auf bisher publizierte Erfahrungen bei der Indikationsstellung zurückgegriffen werden und der zu erwartende Nutzen einer thrombolytischen Therapie gegenüber möglichen Folgeschäden abgewogen werden.Durch die Entwicklung des Thrombolytikums rt-PA haben sich neue Aspekte für die Lysetherapie bei Kindern ergeben. Eine fibrinolytische Behandlung mit rt-PA bietet den großen Vorteil einer weitgehend fibrinspezifischen Wirkung im Gegensatz zu Streptokinase und Urokinase. Ein weiterer Vorteil liegt in der guten Steuerbarkeit der fibrinolytischen Therapie mit rt-PA aufgrund der kurzen Halbwertszeit.Generell sollte die Indikation zur Thrombolyse im Kindesalter gestellt werden, wenn von dem thrombotischen Verschluß unmittelbar eine Lebensbedrohung ausgeht oder wenn eine lebensbedrohliche Krankheitsprogredienz durch eine erfolgreiche Lyse abgewendet werden kann. Außerdem ist die Indikation zur Lyse dann gegeben, wenn ein sicherer oder möglicher Dauerschaden aus dem Thromboseereignis erwächst. Eine Lyse kann auch indiziert sein, wenn dadurch Beschwerden des Patienten bekämpft werden oder ein thromboembolisches Ereignis beziehungsweise ein Thromboserezidiv verhindert werden kann. Vor jeder Indikationsstellung müssen eventuelle Kontraindikationen beachtet werden. Eine Relativierung der Kontraindikationen ist bei vitaler Indikation beziehungsweise bei zu erwartenden schweren Folgeschäden zu erwägen.
Espectro de hallazgos por TC multidetector en el trauma esplénico y hepático
Authors: Ghezzo Andrés C. , Adri Daniel O. , Gentile Ernestina , Yetati Ezequiel Levy 
Published: July 2018

ResumenEl trauma abdominal cerrado puede ser causa de lesiones en varios órganos sólidos, siendo el bazo y el hígado más frecuentemente afectados en ese tipo de situaciones. La tomografía computada multicorte (TCMC), es el método de imágenes de elección en la evaluación de pacientes que sufrieron un trauma cerrado abdominal gracias a que aporta un rápido y preciso diagnóstico y permite un eficaz tratamiento. El objetivo de este trabajo, es describir el espectro de las lesiones esplénicas y hepáticas encontradas en el trauma abdominal cerrado.
Rhinoplasty—Do Patients and Surgeons See the Same? A Double-Blind Study with 100 Randomized Patients
Authors: Santos Mariline , Carmo Diogo , Neves José , Sousa Cecília , Datema Frank , Ferreira Miguel 
Published: July 2018

AbstractOne of the key points of a successful rhinoplasty is communication between the patient and surgeon. The surgeon needs to get a clear understanding of the patient's motivation for surgery and expectations of the procedure. This information is mandatory in formulating an optimal surgical plan and managing realistic expectations of the procedures. Ideally, surgeons and patients see, discuss, and quantify the same nasal defects. In reality, the subjective nature of perceiving aesthetics can cause variability of inter-rating nasal appearance. Therefore, one might question how well surgeons understand their patients. Do they see what patients see? The aim of this study is to assess the level of agreement on the evaluation of nasal appearance between patients, surgeons, and nonphysicians observers, and try to find predictive factors that cause high interobserver variability. This prospective, observational, and cross-sectional study was performed on a total of 100 randomized patients undergoing rhinoplasty. All patients were photographed before surgery and asked to rate the appearance of their nose on a 10 cm visual analogue scale (VAS) with 0 indicating very ugly and 10 indicating very nice. Subsequently, the photographs of each patient were, independently, rated by two panels: one constituted by two rhinoplasty surgeons and the other by four nonmedical raters. Both panels included European raters from the north (The Netherlands) and south (Portugal). Data regarding age, gender, skin type, and major nasal deformity were also collected. The authors found that there is no statistical agreement between the aesthetical evaluation of the nose between patients and surgeons or patients and nonmedical raters. Based exclusively on the VAS for subjective evaluation of nasal appearance, the authors' findings show that surgeons and patients do not “see the same” and generally, the score attributed by the surgeon is more favorable (almost 1 point higher) than the auto-assessment's score. This is important to realize when communicating about nasal appearance before rhinoplasty.
Facial Asymmetry Index: Validation and Applications in Various Smile Restoration Techniques
Authors: Albathi Monirah , Byrne Patrick , Ishii Masaru , Ishii Lisa , Boahene Kofi , Malm Ian-James 
Published: July 2018

AbstractConsistent and objective evaluation of the paralyzed face is imperative for documenting preoperative findings and assessing postoperative outcomes of reanimation techniques. Static and dynamic facial asymmetry are the key features of the paralyzed face. To date, there is no consensus among surgeons on how best to document facial asymmetry. The authors propose a Facial Asymmetry Index (FAI) as an objective measure of facial asymmetry and validate its use and reliability across numerous reanimation techniques. Frontal photographs of patients with unilateral facial nerve paralysis were analyzed. The length from the medial canthus to the ipsilateral oral commissure was compared between affected and nonaffected sides. The FAI is the difference between the two values, with a higher value reflecting poorer facial symmetry. Validation and reliability testing was then performed. There was a consistent decrease in the FAI with procedural intervention (FAI pre = 10.1, FAI post = 3.17; p < 0.0001). Furthermore, there was excellent inter- and intrarater reliability among independent judges. The FAI is a powerful and accessible tool to quantify operative outcomes for many lower facial nerve reanimation techniques.