bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Gesture and Linguistic Experience on Sign Perception
Authors: Gimeno-Martínez Marc , Costa Albert , Baus Cristina 
Published: June 2019

Abstract
In the past years, there has been a significant increase in the number of people learning sign languages. For hearing second language (L2) signers, acquiring a sign language involves acquiring a new language in a different modality. Exploring how L2 sign perception is accomplished and how newly learned categories are created is the aim of the present study. In particular, we investigated handshape perception by means of two tasks, identification and discrimination. In two experiments, we compared groups of hearing L2 signers and groups with different knowledge of sign language. Experiment 1 explored three groups of children—hearing L2 signers, deaf signers, and hearing nonsigners. All groups obtained similar results in both identification and discrimination tasks regardless of sign language experience. In Experiment 2, two groups of adults—Catalan sign language learners (LSC) and nonsigners—perceived handshapes that could be permissible (either as a sign or as a gesture) or not. Both groups obtained similar results in both tasks and performed significantly different perceiving handshapes depending on their permissibility. The results obtained here suggest that sign language experience is not a determinant factor in handshape perception and support other hypotheses considering gesture experience.
Size Matters: How Over-Investments Relax Liquidity Constraints in Relational Contracts
Authors: Englmaier Florian , Fahn Matthias 
Published: June 2019

Abstract
The corporate finance literature documents that managers tend to over-invest in their companies. A number of theoretical contributions have aimed at explaining this stylised fact and most have focused on a fundamental agency problem between shareholders and managers. This article shows that over-investments are not necessarily the (negative) consequence of agency problems between shareholders and managers but instead might be a second-best optimal response to address problems of limited commitment and limited liquidity. If a firm has to rely on relational contracts to motivate its workforce and if it faces a volatile environment, then investments into general, non-relationship-specific capital can increase the efficiency of a firm’s labour relations.
The lipid droplet protein Pgc1 controls the subcellular distribution of phosphatidylglycerol
Authors: Kubalová Dominika , Káňovičová Paulína , Veselá Petra , Awadová Thuraya , Džugasová Vladimíra , Daum Günther , Malínský Jan , Balážová Mária 
Published: June 2019

ABSTRACT
The biosynthesis of yeast phosphatidylglycerol (PG) takes place in the inner mitochondrial membrane. Outside mitochondria, the abundance of PG is low. Here, we present evidence that the subcellular distribution of PG is maintained by the locally controlled enzymatic activity of the PG-specific phospholipase, Pgc1. A fluorescently labeled Pgc1 protein accumulates on the surface of lipid droplets (LD). We show, however, that LD are not only dispensable for Pgc1-mediated PG degradation, but do not even host any phospholipase activity of Pgc1. Our in vitro assays document the capability of LD-accumulated Pgc1 to degrade PG upon entry to the membranes of the endoplasmic reticulum, mitochondria and even of artificial phospholipid vesicles. Fluorescence recovery after photobleaching analysis confirms the continuous exchange of GFP-Pgc1 within the individual LD in situ, suggesting that a steady-state equilibrium exists between LD and membranes to regulate the immediate phospholipase activity of Pgc1. In this model, LD serve as a storage place and shelter Pgc1, preventing its untimely degradation, while both phospholipase activity and degradation of the enzyme occur in the membranes.
NMR and molecular modeling reveal specificity of the interactions between CXCL14 and glycosaminoglycans
Authors: Penk Anja , Baumann Lars , Huster Daniel , Samsonov Sergey A 
Published: June 2019

Abstract
CXCL14, chemokine (C-X-C motif) ligand 14, is a novel highly conserved chemokine with unique features. Despite exhibiting the typical chemokine fold, it has a very short N-terminus of just two amino acid residues responsible for chemokine receptor activation. CXCL14 actively participates in homeostatic immune surveillance of skin and mucosae, is linked to metabolic disorders and fibrotic lung diseases and possesses strong anti-angiogenic properties in early tumor development. In this work, we investigated the interaction of CXCL14 with various glycosaminoglycans (GAGs) by nuclear magnetic resonance spectroscopy, microscale thermophoresis, analytical heparin (HE) affinity chromatography and in silico approaches to understand the molecular basis of GAG-binding. We observed different GAG-binding modes specific for the GAG type used in the study. In particular, the CXCL14 epitope for HE suggests a binding pose distinguishable from the ones of the other GAGs investigated (hyaluronic acid, chondroitin sulfate-A/C, −D, dermatan sulfate). This observation is also supported by computational methods that included molecular docking, molecular dynamics and free energy calculations. Based on our results, we suggest that distinct GAG sulfation patterns confer specificity beyond simple electrostatic interactions usually considered to represent the driving forces in protein–GAG interactions. The CXCL14–GAG system represents a promising approach to investigate the specificity of GAG–protein interactions, which represents an important topic for developing the rational approaches to novel strategies in regenerative medicine.
On the Standard Poisson Structure and a Frobenius Splitting of the Basic Affine Space
Authors: Peng Jun , Yu Shizhuo 
Published: June 2019

Abstract
The goal of this paper is to construct a Frobenius splitting on $G/U$ via the Poisson geometry of $(G/U,\pi _{{{\scriptscriptstyle G}}/{{\scriptscriptstyle U}}})$, where $G$ is a simply connected semi-simple algebraic group defined over an algebraically closed field of characteristic $p&gt; 3$, $U$ is the uniradical of a Borel subgroup of $G$, and $\pi _{{{\scriptscriptstyle G}}/{{\scriptscriptstyle U}}}$ is the standard Poisson structure on $G/U$. We first study the Poisson geometry of $(G/U,\pi _{{{\scriptscriptstyle G}}/{{\scriptscriptstyle U}}})$. Then we develop a general theory for Frobenius splittings on $\mathbb{T}$-Poisson varieties, where $\mathbb{T}$ is an algebraic torus. In particular, we prove that compatibly split subvarieties of Frobenius splittings constructed in this way must be $\mathbb{T}$-Poisson subvarieties. Lastly, we apply our general theory to construct a Frobenius splitting on $G/U$.
Enhancing efficiency in a cardiac investigations department by increasing remote patient monitoring
Authors: Ryan Paul , McGrath Caitriona , Lawrie Iain , Fitzsimons Caoimhe , O’Shea Jack , De BrÚn Aoife 
Published: June 2019

Abstract

Objective
Remote monitoring (RM) of patients with cardiac rhythm management devices enables healthcare teams to effectively and efficiently monitor patients with heart problems without the requirement in-person patient visits. RM has been associated with safer and higher quality care but was not being used to its full potential in this setting. Cardiac rhythm management had observed an average implant rate of 295 devices per year over the past 13 years, resulting in a five-fold growth in patient follow-up in clinics. This increased demand was becoming unmanageable, with impacts on care quality. This study aimed to enhance the enrolment of eligible patients to RM.

Design
A pre-post design.

Setting
A 600-bed city centre teaching hospital in Dublin, Ireland.

Participants
Hospital staff and patients eligible for RM.

Interventions
Lean Six Sigma methods were used to develop patient education materials on RM and the clinic area was redesigned to enable RM enrolment and monitoring.

Main outcomes measures
Number of unscheduled attendances to clinic and RM enrolment.

Results
At baseline, the clinic was processing 102 RM follow-up checks with 140 unscheduled attendances on average per month. Following implementation, RM enrolment increased to 335 RM follow-up checks (194% increase), with 41 unscheduled attendances on average per month (70% decrease). These results were sustained one-year post-implementation.

Conclusions
These process changes have streamlined workflow by reducing the number of unscheduled attendances to clinic and increased the use of RM among the eligible patient population. This has meant safer, more timely responses to cardiac events and enhanced care quality.
Species distribution and antifungal susceptibility of invasive Candida isolates from Canadian hospitals: results of the CANWARD 2011–16 study
Authors: Fuller Jeff , Dingle Tanis C , Bull Amy , Shokoples Sandy , Laverdière Michel , Baxter Melanie R , Adam Heather J , Karlowsky James A , Zhanel George G ,   Canadian Antimicrobial Resistance Alliance (CARA) and CANWARD, Zhanel George G , Hoban Daryl J , Adam Heather J , Baxter Melanie R , Nichol Kimberly A , Lagacé-Wiens Philippe R S , Walkty Andrew , Karlowsky James A , Blondeau J , Slinger R , Davidson R , Zhanel G , Hoban D , Delport J , Ellis C , Laverdière M , Loo V , Poutanen S , Fuller J , Roscoe D , Desjardins M , Matukas L , Goyette M , Lee C , Carignan A , Bergevin M , Pelletier R 
Published: June 2019

AbstractObjectivesUnderstanding the epidemiology of invasive Candida infections is essential to patient management decisions and antifungal stewardship practices. This study characterized the species distribution and antifungal susceptibilities of prospectively collected isolates of Candida species causing bloodstream infections (BSIs) in patients admitted to tertiary care hospitals located in 14 cities across 8 of the 10 Canadian provinces between 2011 and 2016.MethodsAntifungal susceptibility testing was performed by broth microdilution using CLSI methods, breakpoints and epidemiological cut-off values. DNA sequencing of fks loci was performed on all echinocandin-non-susceptible isolates.ResultsCandida albicans (49.6%), Candida glabrata (20.8%) and Candida parapsilosis complex (12.0%) were the most common species out of 1882 isolates associated with BSIs. Candida tropicalis (5.2%), Candida krusei (4.3%), Candida dubliniensis (4.1%), Candida lusitaniae (1.4%) and Candida guilliermondii (1.1%) were less frequently isolated. Between 2011 and 2016, the proportion of C. albicans significantly decreased from 60.9% to 42.1% (P < 0.0001) while that of C. glabrata significantly increased from 16.4% to 22.4% (P = 0.023). C. albicans (n = 934), C. glabrata (n = 392) and C. parapsilosis complex (n = 225) exhibited 0.6%, 1.0% and 4.9% resistance to fluconazole and 0.1%, 2.5% and 0% resistance to micafungin, respectively. Mutations in fks hot-spot regions were confirmed in all nine micafungin non-susceptible C. glabrata.ConclusionsAntifungal resistance in contemporary isolates of Candida causing BSIs in Canada is uncommon. However, the proportion of C. glabrata isolates has increased and echinocandin resistance in this species has emerged. Ongoing surveillance of local hospital epidemiology and appropriate antifungal stewardship practices are necessary to preserve the utility of available antifungal agents.
How long will treatment guidelines for TB continue to overlook variability in drug exposure?
Authors: Muliaditan Morris , Della Pasqua Oscar 
Published: June 2019

Abstract

Background
Despite wide clinical acceptance, the use of weight-banded dosing regimens for the treatment of TB in adults has been defined on an empirical basis. The potential impact of known covariate factors on exposure to different drugs has not been taken into account.

Objectives
To evaluate the effect of demographic factors on the exposure to standard of care drugs after weight-banded dosing, as currently recommended by TB treatment guidelines. In addition, we aim to identify alternative dosing regimens that ensure comparable systemic exposure across the overall patient population.

Methods
Clinical trial simulations were performed to assess the differences in systemic exposure in a cohort of virtual patients. Secondary pharmacokinetic parameters were used to evaluate the adequacy of each regimen along with the percentage of patients achieving predefined thresholds.

Results
Our results show that patients weighing less than 40 kg are underexposed relative to patients with higher body weight. The opposite trend was observed following a crude weight band-based dosing regimen with 50 kg as the cut-off point. Simulations indicate that a fixed-dose regimen based on three (&lt;40 kg), four (40–70 kg) or five (&gt;70 kg) tablets of 150 mg rifampicin, 75 mg isoniazid, 400 mg pyrazinamide and 275 mg ethambutol reduces variability in exposure, increasing the overall probability of favourable long-term outcome across the population.

Conclusions
These findings suggest the need to revisit current guidelines for the dose of standard of care drugs for TB treatment in adults. The proposed fixed-dose regimen should be considered in future clinical trials.
Airports, access and local economic performance: evidence from China
Authors: Gibbons Stephen , Wu Wenjie 
Published: June 2019

AbstractIn this article, we study the effect of airports on local economic performance that arises from better access to domestic markets in the context of China’s recent airport network expansion. We measure access through the changes in network closeness centrality implied by the contraction in potential journey times between counties within China. Our key finding is that better access—primarily due to landside distance reductions to airports—increased manufacturing productivity. The analysis is carried out on a panel of counties built from micro data on industrial firms, administrative records and census data. To mitigate endogeneity issues, we focus on a subsample of ‘incidentally’ affected counties, whose location midway between existing and new airports implies that they were neither explicitly targeted for development nor directly affected by airport operations.
South Africa’s Journey from Socialism to Human Rights: The True Confessions of an Errant Socialist
Authors: Heywood Mark 
Published: June 2019

Abstract
This article explores the possibilities and pitfalls of various methods of human rights advocacy in post-apartheid South Africa. It does so through following the personal journey of the author, first as a socialist in the anti-apartheid movement and later as a leading human rights activist in some of the most successful civil society organizations to emerge in the post-apartheid period. The journey begins in the pre-constitutional period in 1994 (the year South Africa had its first democratic election) and continues through to 2019. It examines the evolution of human rights practice, particularly in relation to access to treatment for HIV/AIDS and the realization of socioeconomic rights to health care services and basic education. It measures its achievements against the discourse of socialists, particularly their critique of using law, the courts and human rights in the quest for equality. It shows how South Africa has a long tradition of human rights activism that stretches back to the colonial and apartheid periods. However, making human rights justiciable in South Africa’s 1996 Constitution was a game-changer that has enabled tangible victories to be achieved through a combination of litigation and social mobilization. Despite this the author believes that this period of advance may now be reaching its limits and he argues that human rights practice now needs a much deeper consideration of its command over matters of economy and private (corporate) power if it is to retain its credibility in twenty-first century struggles for equality and social justice. The article ends with some suggestions about how this can be done.
The fungal sesquiterpenoid pyrenophoric acid B uses the plant ABA biosynthetic pathway to inhibit seed germination
Authors: Lozano-Juste Jorge , Masi Marco , Cimmino Alessio , Clement Suzette , Fernández Maria A , Antoni Regina , Meyer Susan , Rodriguez Pedro L , Evidente Antonio 
Published: June 2019

AbstractPyrenophoric acid (P-Acid), P-Acid B, and P-Acid C are three phytotoxic sesquiterpenoids produced by the ascomycete seed pathogen Pyrenophora semeniperda, a fungus proposed as a mycoherbicide for biocontrol of cheatgrass, an extremely invasive weed. When tested in cheatgrass bioassays, these metabolites were able to delay seed germination, with P-Acid B being the most active compound. Here, we have investigated the cross-kingdom activity of P-Acid B and its mode of action, and found that it activates the abscisic acid (ABA) signaling pathway in order to inhibit seedling establishment. P-Acid B inhibits seedling establishment in wild-type Arabidopsis thaliana, while several mutants affected in the early perception as well as in downstream ABA signaling components were insensitive to the fungal compound. However, in spite of structural similarities between ABA and P-Acid B, the latter is not able to activate the PYR/PYL family of ABA receptors. Instead, we have found that P-Acid B uses the ABA biosynthesis pathway at the level of alcohol dehydrogenase ABA2 to reduce seedling establishment. We propose that the fungus P. semeniperda manipulates plant ABA biosynthesis as a strategy to reduce seed germination, increasing its ability to cause seed mortality and thereby increase its fitness through higher reproductive success.
Xyloglucan endotransglucosylase-hydrolase30 negatively affects salt tolerance in Arabidopsis
Authors: Yan Jingwei , Huang Yun , He Huan , Han Tong , Di Pengcheng , Sechet Julien , Fang Lin , Liang Yan , Scheller Henrik Vibe , Mortimer Jenny C , Ni Lan , Jiang Mingyi , Hou Xilin , Zhang Aying 
Published: June 2019

AbstractPlants have evolved various strategies to sense and respond to saline environments, which severely reduce plant growth and limit agricultural productivity. Alteration to the cell wall is one strategy that helps plants adapt to salt stress. However, the physiological mechanism of how the cell wall components respond to salt stress is not fully understood. Here, we show that expression of XTH30, encoding xyloglucan endotransglucosylase-hydrolase30, is strongly up-regulated in response to salt stress in Arabidopsis. Loss-of-function of XTH30 leads to increased salt tolerance and overexpression of XTH30 results in salt hypersensitivity. XTH30 is located in the plasma membrane and is highly expressed in the root, flower, stem, and etiolated hypocotyl. The NaCl-induced increase in xyloglucan (XyG)-derived oligosaccharide (XLFG) of the wild type is partly blocked in xth30 mutants. Loss-of-function of XTH30 slows down the decrease of crystalline cellulose content and the depolymerization of microtubules caused by salt stress. Moreover, lower Na+ accumulation in shoot and lower H2O2 content are found in xth30 mutants in response to salt stress. Taken together, these results indicate that XTH30 modulates XyG side chains, altered abundance of XLFG, cellulose synthesis, and cortical microtubule stability, and negatively affecting salt tolerance.
Interpreting the distributions of FRB observables
Authors: Connor Liam 
Published: June 2019

ABSTRACT
Fast radio bursts (FRBs) are short-duration radio transients of unknown origin. Thus far, they have been blindly detected at millisecond time-scales with dispersion measures (DMs) between 110 and 2600 pc cm−3. However, the observed pulse width, DM, and even brightness distributions depend strongly on the time and frequency resolution of the detection instrument. Spectral and temporal resolution also significantly affect FRB detection rates, similar to beam size and system-equivalent flux density. I discuss the interplay between underlying FRB properties and instrumental response, and provide a generic formalism for calculating the observed distributions of parameters given an intrinsic FRB distribution, focusing on pulse width and DM. I argue that if there exist many FRBs of duration <<1 ms (as with giant pulses from Galactic pulsars) or events with high DM, they are being missed due to the deleterious effects of smearing. I outline how to optimize the spectral and temporal resolution for FRB surveys that are throughput-limited. I also investigate how such effects may have been imprinted on the distributions of FRBs at real telescopes, like the different observed DMs at ASKAP and Parkes. Finally, I discuss the impact of intrinsic correlations between FRB parameters on detection statistics.
ASKAP detection of periodic and elliptically polarized radio pulses from UV Ceti
Authors: Zic Andrew , Stewart Adam , Lenc Emil , Murphy Tara , Lynch Christene , Kaplan David L , Hotan Aidan , Anderson Craig , Bunton John D , Chippendale Aaron , Mader Stacy , Phillips Chris 
Published: June 2019

ABSTRACT
Active M dwarfs are known to produce bursty radio emission, and multiwavelength studies have shown that solar-like magnetic activity occurs in these stars. However, coherent bursts from active M dwarfs have often been difficult to interpret in the solar activity paradigm. We present Australian Square Array Pathfinder (ASKAP) observations of UV Ceti at a central frequency of 888 MHz. We detect several periodic, coherent pulses occurring over a time-scale consistent with the rotational period of UV Ceti. The properties of the pulsed emission show that they originate from the electron cyclotron maser instability, in a cavity at least 7 orders of magnitude less dense than the mean coronal density at the estimated source altitude. These results confirm that auroral activity can occur in active M dwarfs, suggesting that these stars mark the beginning of the transition from solar-like to auroral magnetospheric behaviour. These results demonstrate the capabilities of ASKAP for detecting polarized, coherent bursts from active stars and other systems.
AGN-driven quenching of satellite galaxies
Authors: Dashyan Gohar , Choi Ena , Somerville Rachel S , Naab Thorsten , Quirk Amanda C N , Hirschmann Michaela , Ostriker Jeremiah P 
Published: June 2019

ABSTRACT
We explore the effect of active galactic nucleus (AGN) feedback from central galaxies on their satellites by comparing two sets of cosmological zoom-in runs of 27 haloes with masses ranging from 1012 to 1013.4$\rm {M}_{\odot}$ at z = 0, with (wAGN) and without (noAGN) AGN feedback. Both simulations include stellar feedback from multiple processes, including powerful winds from supernovae, stellar winds from young massive stars, AGB stars, radiative heating within Strömgren spheres and photoelectric heating. Our wAGN model is identical to the noAGN model except that it also includes a model for black hole seeding and accretion, as well as AGN feedback via high-velocity broad absorption line winds and Compton/photoionization heating. We show that the inclusion of AGN feedback from the central galaxy significantly affects the star formation history and the gas content of the satellite galaxies. AGN feedback starts to affect the gas content and the star formation of the satellites as early as z = 2. The mean gas-rich fraction of satellites at z = 0 decreases from 15 per cent in the noAGN simulation to 5 per cent in the wAGN simulation. The difference between the two sets extends as far out as five times the virial radius of the central galaxy at z = 1. We investigate the quenching mechanism by studying the physical conditions in the surroundings of pairs of satellites matched across the wAGN and noAGN simulations and find an increase in the temperature and relative velocity of the intergalactic gas.