bluuebunny/crossref_metadata_2025_split huggingface dataset:
PREDICTORS OF CHRONICKIDNEY DISEASEINHUMAN IMMUNODEFICIENCY VIRUS PATIENTS
Authors: Andrushchak M.O. 
Published: June 2018

Purpose: to determine the frequency of diagnosis and predictors of renal disease in HIV-infected patients.
Patients and methods. 292 HIV-infected patients, who were on an outpatient screening at the Chernivtsi Regional AIDS Center, were screened.
Results CKD was diagnosed in 153 out of292 (52.4%) of the examined patients. among which 105 (36.0%) patients were diagnosed with isolated albuminuria/proteinuria, 48 (16.4%) patients had albuminuria /proteinuria, in combination with a decrease in glomerular filtration rate. It has been established that the presence of proteinuria in HIV infection is accompanied by a significantly higher level of HIV RNA compared to patients without this symptom (p < 0.01). At the same time, the average amount of CD4+-lymphocytes in blood serum in patients with proteinuria is significantly lower than in HIV-infected individuals who did not show kidney damage.
The difference between the values of the ratios of CD4+/CD8+-lymphocytes in the analyzed groups (p < 0,05) is also significant.
In most patients who were in the III-IV clinical stage of HIV infection, antiretroviral therapy (ART) was effective and reduced the viral load. Therefore, it is obvious that the amount of HIV-RNA in the blood of these individuals was significantly lower compared to patients who did not receive such treatment. At the same time, the burden of HIV, as well as the number of CD4+-lymphocytes in the representatives of the comparable groups did not differ (p > 0.05).
Conclusion. The main predictors of kidney damage in HIV-infected are: high viral load, decrease in absolute numbers. CD4+-lymphocytes less than 200. Co-infection with hepatitis B and/ or C viruses does not affect the level of proteinuria and GFR in HIV-infected patients.
FIBROBLAST GROWTH FACTOR 23 AS EARLY MARKER OF MINERAL AND BONE DISORDER IN PATIENTS WITH CHRONIC KIDNEY DISEASE
Authors: Chaikovska M. I. , Martynyuk L. P. 
Published: June 2018

The aim: to study the state of regulation of mineral metabolism in CKD by evaluating the serum concentration of c-terminal FGF-23, PTH, Ca, P, and to investigate the relationship between FGF-23 and PTH in CKD.
Materials and methods. The study involved 106 people with CKD, 47women (44%) and 59men (56%) aged (49.6 ± 13.9) years. The C-terminal FGF-23 fragment was determined using a set of reagents for the enzyme immunoassay «Biomedica». The glomerular filtration rate (GFR) was calculated using the CKD EPI formula (KDIGO 2012).
Results. A progressive increase in PTH levels was observed in parallel with the development of renal insufficiency in patients with CKD. Beginning with the CKD stage III, a significant increase above the norm (p <0.05) in the level of PTH ((85.79 ± 29.3) pg / ml) was observed. A progressive increase in the serum concentration of the c-terminal fragment of FGF-23 in patients with CKD was observed along with the GFR decrease. Statistically significant (p <0.05) increase in the concentration of FGF-23 was observed in CKD stage II ((1.29 ± 0.08) pmol / L) compared with CKD I ((0.76 ± 0.07) pmol / L). A strong negative association was found between FGF-23 and GFR (r = -0.87, p <0.05) in CKD. The existence of a strong direct association (r = 0.84, p <0.05) between the level of PTH and FGF-23 in CKD was established.
Conclusions. Growth of the level of FGF-23 outstrips the increase in PTH in the time interval by 1 stage of CKD. C-terminal FGF-23 can be used as an early marker of the development of mineral disturbances in patients with CKD.
ROLE OF HUMAN DISKOIDIN DOMAIN RECEPTOR 1 IN THE PROGRESSION OF CHRONIC PYELONEPHRITIS IN CHILDREN
Authors: Kaladze N. N. , Slobodyan E. I. 
Published: June 2018

The purpose: to evaluate the role of collagen receptors Human Discoidin Domain Receptors (DDR1) as mediators of inflammation, proliferation and fibrosis in children with chronic pyelonephritis (CP), to reveal their relationship to the clinical form of the disease and the characteristics of its flow.
Materials and methods: The levels of DDR1, transforming growth factor (TGF-β1), insulin-like growth factor (IGF-1) in the serum, β2 - microglobulin ( β2- MG) in the serum and urine were identified during the study of 40 children, ages 6 to 16 with CP in a state of clinical and laboratory remission.
Results: Clinical and laboratory remission HP was associated with significant increased levels of DDR1 sera from long ill patients with frequent exacerbations, as well as 2-3 degree of activity last exacerbation, with family history. Found a strong inverse correlation between the levels of DDR1 and IGF-1, and the line with TGF-β1 and β2-MG of blood and urine. In patients with obstructive HP DDR1 level was significantly higher than in patients with non-obstructive clinical form.
Conclusions: Increased serum DDR1 shows the progression of kidney damage with active fibrogenesis and inflammation in certain categories of patients with CP in a state of clinical and laboratory remission.
VASOMOTOR FUNCTION OF THE ENDOTHELIUM IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND HYPERTENSION
Authors: Demikhova N. V. , Vlasenko M. A. , Kurshubadze E. , Sukhonos V. A. 
Published: June 2018

Investigation of the functional state of the vascular endothelium contributes to the further study of the mechanisms of development and pharmacological correction, particularly in hypertensive patients with chronic kidney disease.
Material and Results. The study involved 172 patients with arterial hypertension (AH) in patients with chronic kidney disease. In the study of vascular-motor response to decompression and test with nitroglycerin in 60% of cases occur reduced vasodilatory and in 12.6% constrictor response. Normal character of vasodilation was 27.4%. Endothelium-independent vasodilation in the brachial artery decompression was reduced by 51.1% compared with the control. The growth of endothelium-independent vasoconstriction in the degree III AH was reduced to a lesser degree than the endothelium dependent - by 6.5% and 19.4% (p<0.01), respectively.
Conclusion. Thus impaired endothelium-mediated autoregulation of vascular tone in hypertensive patients with chronic kidney disease is an important element in the pathogenesis of high blood pressure as one of major adaptation mechanisms.
INFLUENCE OF EPOETIN ALFA ON LEVEL OF PROINFLAMMATORYAND ANTIINFLAMMATORY CYTOKINE OF PATIENTS IN MAINTENCE HEMODIALYSIS
Authors: Dudar I. , Gonchar Y. , Savchuk V. , Shifris I. , Loboda O. 
Published: June 2018

Summary. The aim of the present research was to study the influence of еpoetin alfa to the level of pro- and anti-inflammatory cytokines in patients with anemia treated by hemodialysis (HD).
Materials and methods: We examined 73patients with anemia treated by hemodialysis (mean age 45,85 ±1,21 years). Patients were divided into 2groups: I group - comparison (n = 32), II group - treatment by epoetin alfa (n = 41). The levels of hemoglobin, C-reactiveprotein, ferritin, albumin, pro-and anti-inflammatory cytokines were determined before and after treatment in patients of both groups. The duration of treatment was 5 months.
Results: Epoetin alfa increases Hb levels in patients treated by HD. After epoetin alfa applying reduction of proinflammatory cytokines ( TNF -a, IL -ip, IL -17, IL -18) and increased levels of IL -10 were observed.
Conclusions: The clinical efficacy of the epoetin alfa treatment at the moment of completion of treatment was 75.6% (level of Hb > 110 g/L ). Epoetin alfa, improving the level of Hb, reduces the activity of chronic inflammation.
EARLYDIAGNOSIS OFINTRARENAL BLOOD FLOW DISORDERSIN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION
Authors: Krutikov E. , Chistyakova S. , Gorbatyuk S. , Cvetkov V. 
Published: June 2018

Summary. Among the causes of end-stage renal failure essential arterial (EAH) hypertension has a leading place. One of thepathogenic mechanisms of hypertensive nephropathy is a violation of intrarenal blood flow. The purpose of this study was to conduct an early diagnosis of intrarenal blood flow disorders using Doppler examination and comparison of these data with the standard criteria of nephropathy in EAH.
Materials and methods. 80patients with stage II EAH were examined.
Results. In patients with grade II and III EAH noted depletion of intrarenal blood flow, characterized by low Vmax and Vmin, while there was an increase IR characterizing renal vascular resistance. Hyper phase in hypertensive nephropathy was characterized by a relative increase in hemodynamic indices at the level of the trunk of the renal artery and segmental artery with a reduction in the small arteries to the level in healthy people. Hypofiltration phase was characterized by a significant reduction of velocity indexes that accompanied by a decreasing of vascular resistance (theirpseudonormalization). In assessing renal hemodynamics in patients with EAH and microalbuminuria showed a decreasening of Vmin and increasening of IR. A inverse correlation between the level of night BP decreasing and IR segmental artery (r = - 0,61, p<0,05).
Conclusions: 1. In patients with essential hypertension grade IIand IIImarked depletion of intrarenal blood flow characterized by a decrease in peak systolic and minimum diastolic velocity. At the same time there is increasing resistance indices characterizing renal vascular resistance. 2. Early stage of fypertensive nephropathy criteria before the development of microalbuminuria, hyperfiltration can be the increase in the indices at the level of resistance of main and segmental arteries according to Doppler examination of renal vessels. 3. In patients with essential hypertension and microalbuminuria there is a decrease in diastolic velocity and resistive index increase, indicating an increase in intrarenal vascular resistance and may also be a diagnostic criterion of nephropathy. 4. The inverse correlation between the level of nighttime decrease in blood pressure and segmental artery resistance index indicate the negative impact of the lack of night reduction in blood pressure to renal function in hypertension.
RELATIONSHIP OF THE CONDITION OF THE MYOCARDIUM WITH INFRINGEMENTS THE CALCIUM AND PHOSPHORUS METABOLISM INPATIENTS WITH DIABETIC NEPHROPATHY
Authors: Topchii I.I. , Denisenko V.P. , Kirienko O.M. , Semenovykh P.S. , Yakimenko Yu.S. , Mazii V.V. , Schenyavskaya O.M. 
Published: June 2018

Objective: To establish the possible relationship between changes in cardiac hemodynamics and im-paired phosphate-calcium metabolism and content FGF 23.
Patients and Methods: 260 people with diabetic nephropathy, 64 people with hypertension and 20 healthy individu-als were surveyed. Studied the state of the myocardium and cardiac hemodynamics, blood levels of calcium, phosphorus and FGF 23.
Results and conclusions: between the state of myocardium, cardiac hemodynamics and content FGF23, phos-phorus and calcium are closely interrelated, which is likely mediated through specific receptor apparatus of myocardium and through immunoinflammatory mechanisms. However, the specific mechanisms of action system FGF23 / phosphorus-calcium exchange for anatomical and functional myocardial changes require further investigation.
CORRECTING OF ANEMIA USING IRON SUCROSE IN PATIENTS WITH CHRONIC KIDNEYDISEASE STAGE VD ON HEMODIALYSIS
Authors: Dudar I. , Shifris I. , Gonchar Y. , Savchuk V. , Loboda O. , Krasyuk E. , Aleksieva N. 
Published: June 2018

Anemia is a common complication of CKD. Iron deficiency is one of a leading cause of anemia in HD patients. The causes of iron deficiency in these patients are multifactorial. Main factors that contribute to iron deficiency in HD patients are reduction intake and impaired intestinal absorption of dietary iron, blood losses, chronic inflammation and increased iron requirements during therapy with erythropoiesis–stimulating agents.
Aim.The aim was to study efficacy and safety of iron sucrose (Venofer) in HD patients with anemia.
Materials and methods. This study was an retrospective, epidemiologic, performed from 2010 to 2014 years. The study included 69 HD patients with anemia from dialysis single–center. 38 (55.1%) patients were men, average age 49,53 ± 3,9years and the most common cause of ESRD was glomerulonephritis (37 patients, 53.6%). Hemoglobin value was analyzed weekly. The levels of serum ferritin and transferrin saturation, were determined before and after treatment with Venofer.
Results. Treatment with the Venofer resulted a significant increase of hematological and iron exchange parameters. At 2 – 3 weeks of therapy, hemoglobin levels increased by 7,6% and 10,7%, respectively. 14 days after the last dose Venoer serum ferritin and transferrin saturation levels have increased by 58% and 55%, respectively.
Conclusions. Intravenous iron is the preferred route of administration in HD patients. Venofer showing a significant increase both of hemoglobin and iron exchange markers levels on a background of insignificant frequency of treatment–related adverse events.
EFFECT OF CANDESARTAN ON PARAMETERS OFDAILYBLOOD PRESSURE IN PATIENTS WITH CHRONIC KIDNEYDISEASE ON HEMODIALYSIS
Authors: Vizir V. A. , Ovska О. G. , Sadomov A. S. 
Published: June 2018

Introduce.Advances of normal blood pressure in patients on program hemodialysis presented a serious problem related disciplines. For verification hypertension used routine blood pressure measurement and ambulatory monitoring to control the pressure in interdialytic time, which is an important predictor of cardiovascular events among these patients.
The aim of research was to investigate features ofparameters the ambulatory monitoring of blood pressure in the dynamics after treatment of candesartan in patients receiving renal replacement therapy.
Materials and methods: 53patients ongoing chronic hemodialysis were makethe ambulatory monitoring of blood pressure before and after 12–weeks treatment of candesartan (4–32 mg).
Results. It was established that the prevalence of hypertension in a population of patients on hemodialysis influenced by candesartan treatment decreased from 53.6 % to 32.1 %. Patients on hemodialysis in 75 % of cases have incresedpulse pressure (> 60 mm Hg), the percentage of which after therapy decreased to 51.8. Prevailing type of daily blood pressure as the treatment and after treatment is «non–dipper». Established that candesartan showed a positive effect in relation to a statistically significant reduction in the average time indices and blood pressure
Conclusion: results of the study allowtorecommend candesartan for treatment of hypertension in hemodialysis patients.
ASSOCIATIONS OF BLOOD GROUPS ANTIGENS OF AB0 AND RHESUS SYSTEMS WITH THE DEVELOPMENT OF CHRONIC KIDNEY DISEASE, GLOMERULONEPHRITIS
Authors: Kaminskyy V. , Kovalchuk L. 
Published: June 2018

Introduction. Finding of biological markers of genetic predisposition to the formation of glomerulonephritis (GN) will promote prediction the probability of its development still at an early stage and provide the growth of preventive direction of medicine. The purpose of the study is to evaluate the risk of GN development by antigens of AB0 and rhesus (Rh) blood groups.
Materials and methods. The study included 434patients with GN(242M, 192F, aged 37.56 ± 13.01y). 1428 healthy persons was surveyed to determine the distribution of phenotypes of AB0 and Rh blood groups in the population.
Results. The total value of the relative risk of GN development in all Rh–negative carriers ABprevailed by 2.34 times in the same Rh–positive. The total value of the relative risk of disease appearance in Rh–negative individuals prevailed in the same Rh–positive according to gender: in men with A and AB – 6.43 and 4.16 times, respectively, in women with B and AB – 9.34 and 2.15 times, respectively. In all patients, the common feature was a high chance of getting sick by GN in carriers phenotype AB Rh– versus 0 Rh–.
Conclusions. The sex dimorphism of hereditary predisposition markers for GN is proved: men with phenotypes A Rh– and AB Rh–, women with B Rh–, AB Rh– and AB Rh+ have high risk to be ill. The persons of both sexes with phenotype 0 Rh–, as well as men with B Rh– and women with A Rh– and B Rh+ may be resistant to disease.
PECULIARITIES OF PRODUCTION OF SECRETORY LEUCOCYTE PROTEINASE INHIBITOR IN CHILDREN WITH ACUTE OR CHRONIC PYELONEPHRITIS
Authors: Lavrenchuk O. , Poroshina T. , Bagdasarova I. , Gaisenuk F. , Drannik G. 
Published: June 2018

Aims. The goal of the work is to determine the role and significance of the level of the secretory leucocyte proteinase inhibitor (SLPI) in children’s blood and urine with acute (A) and chronic (Ch) pyelonephritis (PN).
Materials and methods. In 26 patients with ChPN in the stage of remission and in 12patients with ChPN at the stage of exacerbation, and in 19 patients with APN were used to study the level ofSLPI in children’s blood and urine by the enzyme–linked immunosorbent assay and corresponding test–systems.
Results. It was found that statistically significant difference between the concentration ofSLPI in children with APN and ChPN, and, accordingly, in the acute stage and remission of ChPN not found (p<0.05). There is a correlation between the concentration ofSLPI and the number of lymphocytes in the peripheral blood (p<0,05) in patients with APN (rK=0,605) and with ChPN at the stage of exacerbation (rK=536). Correlations between the level ofSLPI, C–reactive protein and erythrocyte sedimentation rate and the numbers of neutrophils is not installed (p>0,05).
Conclusions. The results indicated the participation ofSLPI into the pathogenesis of APN and ChPN at the stage of exacerbation.
THE RESULTS AND EFFECTIVENESS OF THE IMPLEMENTATION OF LOCAL PROTOCOLS NEPHROLOGYMEDICAL CARE TO CHILDREN IN CHERNIVTSI REGION
Authors: Bezruk V.V. , Andriychuk T.P. , Pervozvanska O.I. 
Published: June 2018

First identify the incidence of kidney disease and urinary tract, and, accordingly, the disability are important indicators of the health status of the child population in Ukraine.
The objective. Analysis of the effectiveness of the implementation of local protocols Nephrology medical care to children in Chernivtsi region.
Materials and methods. The material for this study is reporting documentation about the condition of the nephrological service care for children’s population of the Chernivtsi region in 2013 - 2014 and the data of The Center of medical statistics of Ministry of Health of Ukraine.
Results and discussion. Analyzes the main indicators of child nephrology service in Chernivtsi region. The introduction of local protocols and clinical trials of patients with nephrological diseases in medical institutions of Chernivtsi region had a positive impact on reducing prevalence and first identified in the incidence of diseases of the urinary system in children’s Chernivtsi region for 2014, which for the first time in recent years do not exceed national statistics.

Conclusion. The introduction of local protocols and clinical trails pediatric patients Nephrology pathology in medical institutions ofChernivtsi region have improved the quality of care at all stages, respecting the standards for the provision of specialized medical care.
THE STATUS OF NO - SYNTHASE/ARGINASE SYSTEM AND OXIDATIVEPROCESSES IN LYMPHOCYTESLYSATEINBLOOD OF PATIENTS WITHDIABETICNEPHROPATHY AFTER THE SESSION OF HEMODIALYSIS
Authors: Ivanochko R. B. 
Published: June 2018

The aim of our study was to examine the state of the NO - synthase/arhynaza and oxidative processes in blood lysates lymphocytes of patients with diabetic nephropathy on hemodialysis conditions. Materials and methods. The study included 21 patients (men – 8 women – 13) with diabetic nephropathy receiving treatment ZNT by dialysis 3 times a week. (12 hrs.) In bicarbonate mode. The average age of patients was 52 years. Comparison group consisted of 20 blood donors, average age – 48years.
Research results. In lysate lymphocytes compared with the control group patients, noted: increase activity levels iNOS (6 times, p <0.001) and the content of TBA - activeproducts - by 23%o; reduction - of eNOS activity by 19.6%, 20.5% SOD (p <0.001), L - arginine content of 33% (p <0.001). The activity of arginase and nitryn anion content expressed did not change. After dialysis session lysate in lymphocytes compared with those for GC, decreased activity level at 72.1% iNOS and eNOS activity by 43% (p <0,001). Reducing the concentration ofL - arginine by 21.5% (p <0.001), nitrite anion by 20% (p <0.001), TBA - active products 22%o, compared with the figures for dialysis. Arginase activity did not significantly change.
Conclusions. Hemodialysis caused a sharp decrease in activity of iNOS, eNOS, content ofTBA - activeproducts, Larginine, nitrate anion in the lysate of lymphocytes in patients with diabetic nephropathy. GD in patients with diabetic nephropathy nitrozooksydatyvnoho stress causes a decrease in lymphocytes, with sharply reduced activity of eNOS. Reduced activity of eNOS and L - arginine in lymphocytes after GC can cause a decrease in immunological protection in patients with diabetic nephropathy and influence life expectancy.
AUTONOMIC STATUS OF PERITONEAL DIALYSIS PATIENTS AND ITS RELATION WITH INDICATORS OFLIPID METABOLISM
Authors: Ablogina O. , Stepanova N. , Sviridova N. , Ponomarenko Y.U. , Dudar I. , Krasiuk E. , Loboda O. , Kolesnyk M. 
Published: June 2018

The research objective had been to evaluate the autonomic status in peritoneal dialysis (PD) patients and to identify its lipid metabolism interaction.
Patients and methods. During the research process 40patients had been examined who received continuous ambulatory peritoneal dialysis (CAPD). The autonomic status was studied using the questionnaire (A.N. Wayne test) and sympathetic skin response (SSR) by electroneuromyograph «Neuro–MEP–4». 20 conventionally healthy individuals formed the control group matched according to age and sex.
Results. Obtained questionnaire data showed clinical symptoms of autonomic dysfunction in 37 cases among 40 (92,5%) PD patients. Analysis of the correlation level of autonomic disorders with lipid metabolism showed a significant dependence with the concentration of high density lipoprotein (HDL) (p=–0,43;p=0,01), low density lipoprotein (LDL) (p=0,55; p=0,001) and atherogenic index. Also a comparative analysis of the main CSAP PD patients’ indicators and conditionally healthy individuals showed a statistically significant decrease in the amplitudes of the first and second phases of SSR. Also SSR results analysis in conjunction with the autonomic disorders clinical implications afforded the ground for the lower extremities polyneuropathy diagnosis in 18 cases among 25 (72%) patients. Moreover, the study of lipid profile showed the correlation of total cholesterol (TC) with all studied SSR parameters: A1 (r=0,64; p=0,0006), A2 (r=0,79; p<0,0001), latent period (LP) (r=–0,45; p=0,04).
Conclusions. The autonomic status of CAPD patients is characterized by low level of vegetative regulation total power and the imbalance of sympathetic and parasympathetic influences in comparison with conventionally healthy individuals and it is correlated with lipid spectrum.
NEFROPROTECTIVE EFFECTS OF ACTOVEGIN IN PATIENTS WITH DIABETIC NEPHROPATHY
Authors: Topchii І.І. , Yakymenko Y.Y. , Semenovykh P.S. , Galchinskaya V.Yu. , Yefimova N.V. 
Published: June 2018

Apoptosis, programmed cell death, regarded as one of the main mechanisms of glomerulosclerosis in diabetic nephropathy (DN).
The aim of the present researchto study the effects of actovegin on cell apoptosis in patients with DN. Materials and methods: we examined 80 type 2 diabetic patients with DN I - IVstages and 10 healthy subjects. CD95+cells number was evaluated by indirect immunohis tochemistry.Results: CD95+ - cells number in the peripheral blood of patients with DN was significantly higher than in healthy donors. The additional actovegin treatment was accompanied by a significant decrease of the investigated parameter when compared with the base therapy.