bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the Infrared Transient VVV-WIT-06: The Case for the Origin as a Classical Nova*
Authors: Banerjee D. P. K. , Hsiao E. Y. , Diamond T. , Galbany L. , Morrell N. , Minniti D. , Kuncarayakti H. , Mattila S. , Harmanen J. 
Published: November 2018

Abstract
The enigmatic near-infrared transient VVV-WIT-06 underwent a large-amplitude eruption of unclear origin in 2013 July. Based on its light curve properties and late-time post-outburst spectra, various possibilities have been proposed in the literature for the origin of the object, namely a Type I supernova, a classical nova (CN), or a violent stellar merger event. We show that, of these possibilities, an origin in a CN outburst convincingly explains the observed properties of VVV-WIT-06. We estimate that the absolute K-band magnitude of the nova at maximum was M
k = −8.2 ± 0.5, its distance d = 13.35 ± 2.18 kpc, and the extinction A
v = 15.0 ± 0.55 mag.
ANKLE FUSION: A RETROSPECTIVE REVIEW
Authors: Aaron Alan D 
Published: November 2018

ABSTRACT
The results of ankle fusion were reviewed in 26 patients who underwent 32 arthrodesis procedures. Posttraumatic degenerative arthritis was the most common indication for fusion (54%). Crossed cancellous screws were the primary method employed (43%), with an external fixator being used in 22% of cases. The overall union rate was 81%, with both crossed cancellous screws and external fixation attaining the best results (86%). Nonunion and infection were the most frequent complications. Progression of subtalar arthritis was demonstrated in 29% of patients postoperatively. Seventy-eight percent of patients graded extremity appearance as excellent or good, with the majority being able to return to work.
Quantitative Assessment of the Choriocapillaris in Patients With Retinitis Pigmentosa and in Healthy Individuals Using OCT Angiography
Authors: Guduru Abhilash , Al-Sheikh Mayss , Gupta Arushi , Ali Hasnat , Jalali Subhadra , Chhablani Jay 
Published: November 2018

BACKGROUND AND OBJECTIVE:
To characterize the choriocapillaris (CC) vasculature in patients with retinitis pigmentosa (RP) and healthy controls using optical coherence tomography angiography (OCTA).

PATIENTS AND METHODS:
The CC of patients with RP and controls was analyzed using OCTA. Areas of no-flow, termed flow voids (FVs), were denoted in both. Comparisons between groups were done using Wilcox tests and generalized estimating equations.

RESULTS:

Fifty-four patients were included. There was a significant difference in spherical equivalent (
P
< .001). The number of FV was 55.5 ± 20.1 in the RP eyes versus 30.7 ± 16.3 in the controls (
P
< .001). The average FV area was 0.33 ± 0.12 mm
2
in the RP eyes and 0.18 ± 0.10 mm
2
in the controls (
P
< .001).

CONCLUSIONS:
There are significantly more FV in patients with RP than in healthy subjects, suggesting it is vital to understanding pathophysiology of RP. Further studies should be done to determine if the compromised CC is a result or cause of RP.

[
Ophthalmic Surg Lasers Imaging Retina
. 2018;49:e122–e128.]
Comparison of Two Modified Sutureless Techniques of Scleral Fixation of Intraocular Lens
Authors: Kelkar Aditya , Kelkar Jai , Kothari Akshay , Mehta Hetal , Chitale Sampada , Fogla Rajesh , Kelkar Shreekant 
Published: November 2018

BACKGROUND AND OBJECTIVE:
To compare the visual outcome and complications of two different sutureless scleral-fixated intraocular lens (IOL) implantation techniques, that is, intrascleral IOL fixation technique and modified Yamane's technique of scleral fixation of IOL.

PATIENTS AND METHODS:
Patients who underwent scleral fixation of IOL (SFIOL) from June 2015 to February 2017 with more than 6 months of follow-up were examined retrospectively. Improvement in visual acuity (VA), intraocular pressure (IOP) measurements, endothelial cell count, central macular thickness (CMT), and intraoperative/postoperative complications were compared at 6 months follow-up.

RESULTS:
Seventy eyes were analyzed. The mean follow-up was 10.5 months ± 1.5 months. The final visual outcomes in both groups, modified intrascleral IOL fixation technique (Group A, n = 30) and modified Yamane's technique (Group B, n = 40), were comparable. The indications for surgery were aphakia (n = 15), subluxated/dislocated cataract (n = 31), and dislocated/subluxated IOL (n = 24). The majority of the eyes (92%) improved to VA 0.3 logMAR units or better. The uncorrected distance visual acuity (UDVA), endothelial cell density, and CMT at the 6-month follow-up were comparable in both groups. Postoperatively, transient IOP rise occurred in 18 eyes, retinal detachment in one eye, vitreous hemorrhage in one eye, cystoid macular edema in two eyes, and mild IOL decentration in two eyes.

CONCLUSION:
Both techniques have favorable visual outcomes; however, modified 27-gauge needle-assisted Yamane's technique is technically superior because of its transconjunctival approach and less surgical time, and its needle-assisted approach for haptic externalization prevents haptic damage during externalization.

[
Ophthalmic Surg Lasers Imaging Retina
. 2018;49:e129–e134.]
Critical Role of Macrophage FcγR Signaling and Reactive Oxygen Species in Alloantibody-Mediated Hepatocyte Rejection
Authors: Zimmerer Jason M. , Liu Xin L. , Blaszczak Alecia , Avila Christina L. , Pham Thomas A. , Warren Robert T. , Bumgardner Ginny L. 
Published: November 2018

Abstract
Humoral alloimmunity negatively impacts both short- and long-term cell and solid organ transplant survival. We previously reported that alloantibody-mediated rejection of transplanted hepatocytes is critically dependent on host macrophages. However, the effector mechanism(s) of macrophage-mediated injury to allogeneic liver parenchymal cells is not known. We hypothesized that macrophage-mediated destruction of allogeneic hepatocytes occurs by cell–cell interactions requiring FcγRs. To examine this, alloantibody-dependent hepatocyte rejection in CD8-depleted wild-type (WT) and Fcγ-chain knockout (KO; lacking all functional FcγR) transplant recipients was evaluated. Alloantibody-mediated hepatocellular allograft rejection was abrogated in recipients lacking FcγR compared with WT recipients. We also investigated anti-FcγRI mAb, anti-FcγRIII mAb, and inhibitors of intracellular signaling (to block phagocytosis, cytokines, and reactive oxygen species [ROS]) in an in vitro alloantibody-dependent, macrophage-mediated hepatocytoxicity assay. Results showed that in vitro alloantibody-dependent, macrophage-mediated hepatocytotoxicity was critically dependent on FcγRs and ROS. The adoptive transfer of WT macrophages into CD8-depleted FcγR-deficient recipients was sufficient to induce alloantibody-mediated rejection, whereas adoptive transfer of macrophages from Fcγ-chain KO mice or ROS-deficient (p47 KO) macrophages was not. These results provide the first evidence, to our knowledge, that alloantibody-dependent hepatocellular allograft rejection is mediated by host macrophages through FcγR signaling and ROS cytotoxic effector mechanisms. These results support the investigation of novel immunotherapeutic strategies targeting macrophages, FcγRs, and/or downstream molecules, including ROS, to inhibit humoral immune damage of transplanted hepatocytes and perhaps other cell and solid organ transplants.
Filtering Next-Generation Sequencing of the Ig Gene Repertoire Data Using Antibody Structural Information
Authors: Kovaltsuk Aleksandr , Krawczyk Konrad , Kelm Sebastian , Snowden James , Deane Charlotte M. 
Published: November 2018

AbstractNext-generation sequencing of the Ig gene repertoire (Ig-seq) produces large volumes of information at the nucleotide sequence level. Such data have improved our understanding of immune systems across numerous species and have already been successfully applied in vaccine development and drug discovery. However, the high-throughput nature of Ig-seq means that it is afflicted by high error rates. This has led to the development of error-correction approaches. Computational error-correction methods use sequence information alone, primarily designating sequences as likely to be correct if they are observed frequently. In this work, we describe an orthogonal method for filtering Ig-seq data, which considers the structural viability of each sequence. A typical natural Ab structure requires the presence of a disulfide bridge within each of its variable chains to maintain the fold. Our Ab Sequence Selector (ABOSS) uses the presence/absence of this bridge as a way of both identifying structurally viable sequences and estimating the sequencing error rate. On simulated Ig-seq datasets, ABOSS is able to identify more than 99% of structurally viable sequences. Applying our method to six independent Ig-seq datasets (one mouse and five human), we show that our error calculations are in line with previous experimental and computational error estimates. We also show how ABOSS is able to identify structurally impossible sequences missed by other error-correction methods.
Joint editorial: Invigorating hydrological research through journal publications
Authors: Quinn Nevil , Blöschl Günter , Bárdossy András , Castellarin Attilio , Clark Martyn , Cudennec Christophe , Koutsoyiannis Demetris , Lall Upmanu , Lichner Lubomir , Parajka Juraj , Peters-Lidard Christa D. , Sander Graham , Savenije Hubert , Smettem Keith , Vereecken Harry , Viglione Alberto , Willems Patrick , Wood Andy , Woods Ross , Xu Chong-Yu , Zehe Erwin 
Published: November 2018

Abstract. Editors of several journals in the field of hydrology met during the General
Assembly of the European Geosciences Union (EGU) in Vienna in April 2017.
This event was a follow-up of similar meetings held in 2013 and 2015. These
meetings enable the group of editors to review the current status of the
journals and the publication process, and to share thoughts on future
strategies. Journals were represented at the 2017 meeting by their editors,
as shown in the list of authors. The main points on invigorating
hydrological research through journal publications are communicated in this
joint editorial published in the above journals.
External Fixation in the Emergency Department for Pilon and Unstable Ankle Fractures
Authors: Shah Kalpit N. , Johnson Joey P. , O'Donnell Seth W. , Gil Joseph A. , Born Christopher T. , Hayda Roman A. 
Published: November 2018

Introduction:
Pilon and unstable ankle fractures are often treated initially with an external fixator (ex-fix). Ex-fix application in the emergency department (ED) has been described but not compared with that placed in the operating room (OR).

Methods:
Retrospective, case-cohort study was performed at a level-1 trauma center. Using CPT codes, we identified patients who had surgical fixation of pilon or ankle fractures with an initial ex-fix application (in the ED or the OR). Postoperative outcomes and hospital logistical data were compared between the two groups.

Results:
Ninety-six patients met the inclusion criteria. The average age of patients was 47 years, and 54 (56%) of the patients were men. Thirty-three patients had the ex-fix placed in the OR, whereas 63 patients had the ex-fix placed in the ED. Postsurgical complications (prominent implant, nonunion, deep infection, deep vein thrombosis, loss of reduction) were seen in 6 of 33 patients in the ED ex-fix group and in 8 of 63 patients in the OR ex-fix group (P = 0.51). Deep infections occurred in 2 of 33 patients in the OR ex-fix group and in 5 of 63 patients in the ED ex-fix group (P = 0.71). Revision ex-fix for loss of reduction was performed in 4 of 33 patients in the OR ex-fix group and in 10 of 63 patients in the ED ex-fix group (P = 0.59). Mean length of stay was 14 days for the OR ex-fix group and 13 days for the ED ex-fix group (P = 0.35).

Conclusion:
No statistically significant differences were found in postsurgical complications (surgical or infectious) or ex-fix revision rates for the ED ex-fix group and the OR ex-fix group. Results indicate that uniplanar ex-fix may be safely applied in the ED.

Level of Evidence:
Level III, therapeutic
High-Performance Thin-Layer Chromatographic Fingerprints of Triterpenoids for Distinguishing Between Isodon lophanthoides and Isodon lophanthoides var. gerardianus
Authors: Lin Chaozhan , Liu Fangle , Zhang Runjing , Liu Meiting , Zhu Chenchen , Zhao Jing , Li Shaoping 
Published: November 2018

Abstract
Background: The aerial parts of Isodon lophanthoides (Buch. Ham. ex D. Don) Hara (IL) has been officially recorded as Isodonis lophanthoidis herba by many provincial quality control standards for Chinese herbal medicines in China. Recently, it has been found that one of its varieties, I. lophanthoides var. gerardianus (Benth.) Hara (ILVG) was pretended to be I. lophanthoidis herba in herbal material markets or cultivated bases. Because of the similarity on appearance, these two close-related species were difficult to be identified by morphological characters, especially when they are dried and sliced. Objective: To establish a rapid and specific method for identification of the two herbal medicines. Method: In this paper, a fingerprint of triterpenoids by HPTLC coupled with a digital profiling was established to identify IL and distinguish it from its substitute, ILVG. The specific HPTLC fingerprints constructed by determining twelve batches of IL samples and thirteen batches of ILVG samples, intuitionally reflected the difference between the two species on HPTLC image and the peak-peak rations of chemical distribution. Results: Authentication results of nine batches of commercial samples by the above established HPTLC fingerprints exhibited coincident conclusion with that by morphological means. Conclusions: The HPTLC fingerprint is proven to be simple, repeatable, specific, and suitable for rapid identification of I. lophanthoidis herba. Highlights: An efficient method for identification and distinguishing Isodon lophanthoides from its substitute, I. lophanthoides var. gerardianus, was established. HPTLC fingerprints of ursane-type triterpenoides were constructed and validated by determining IL and ILVG samples.
Strategies to Meet The Challenges Of Global Education: Prospects of Asian Higher Education
Authors: Khan Sabur 
Published: November 2018

Since human development is a key input to the goal of inclusive and shared economic growth and poverty alleviation, we need to put considerable emphasis on human development. Human capital, in a broad sense, includes education, skills, training, health and other related factors of work forces that determine their overall productivity and capacity to seize opportunities created by economic progress. In this globalized world, the idea and thoughts of internationalization of higher education especially in developing countries like Bangladesh has been deduced from globalization of education process.
Metasurfaces Atop Metamaterials: Surface Morphology Induces Linear Dichroism in Gyroid Optical Metamaterials
Authors: Dolan James A. , Dehmel Raphael , Demetriadou Angela , Gu Yibei , Wiesner Ulrich , Wilkinson Timothy D. , Gunkel Ilja , Hess Ortwin , Baumberg Jeremy J. , Steiner Ullrich , Saba Matthias , Wilts Bodo D. 
Published: November 2018

AbstractOptical metamaterials offer the tantalizing possibility of creating extraordinary optical properties through the careful design and arrangement of subwavelength structural units. Gyroid‐structured optical metamaterials possess a chiral, cubic, and triply periodic bulk morphology that exhibits a redshifted effective plasma frequency. They also exhibit a strong linear dichroism, the origin of which is not yet understood. Here, the interaction of light with gold gyroid optical metamaterials is studied and a strong correlation between the surface morphology and its linear dichroism is found. The termination of the gyroid surface breaks the cubic symmetry of the bulk lattice and gives rise to the observed wavelength‐ and polarization‐dependent reflection. The results show that light couples into both localized and propagating plasmon modes associated with anisotropic surface protrusions and the gaps between such protrusions. The localized surface modes give rise to the anisotropic optical response, creating the linear dichroism. Simulated reflection spectra are highly sensitive to minute details of these surface terminations, down to the nanometer level, and can be understood with analogy to the optical properties of a 2D anisotropic metasurface atop a 3D isotropic metamaterial. This pronounced sensitivity to the subwavelength surface morphology has significant consequences for both the design and application of optical metamaterials.
2D Transition Metal Carbides (MXenes) for Carbon Capture
Authors: Persson Ingemar , Halim Joseph , Lind Hans , Hansen Thomas W. , Wagner Jakob B. , Näslund Lars‐Åke , Darakchieva Vanya , Palisaitis Justinas , Rosen Johanna , Persson Per O. Å. 
Published: November 2018

AbstractGlobal warming caused by burning of fossil fuels is indisputably one of mankind's greatest challenges in the 21st century. To reduce the ever‐increasing CO2 emissions released into the atmosphere, dry solid adsorbents with large surface‐to‐volume ratio such as carbonaceous materials, zeolites, and metal–organic frameworks have emerged as promising material candidates for capturing CO2. However, challenges remain because of limited CO2/N2 selectivity and long‐term stability. The effective adsorption of CO2 gas (≈12 mol kg−1) on individual sheets of 2D transition metal carbides (referred to as MXenes) is reported here. It is shown that exposure to N2 gas results in no adsorption, consistent with first‐principles calculations. The adsorption efficiency combined with the CO2/N2 selectivity, together with a chemical and thermal stability, identifies the archetype Ti3C2 MXene as a new material for carbon capture (CC) applications.
Conjugated Cobalt Polyphthalocyanine as the Elastic and Reprocessable Catalyst for Flexible Li–CO2 Batteries
Authors: Chen Junmei , Zou Kaiyi , Ding Pan , Deng Jun , Zha Chenyang , Hu Yongpan , Zhao Xuan , Wu Jialing , Fan Jian , Li Yanguang 
Published: November 2018

AbstractLi–CO2 batteries represent an attractive solution for electrochemical energy storage by utilizing atmospheric CO2 as the energy carrier. However, their practical viability critically depends on the development of efficient and low‐cost cathode catalysts for the reversible formation and decomposition of Li2CO3. Here, the great potential of a structurally engineered polymer is demonstrated as the cathode catalyst for rechargeable Li–CO2 batteries. Conjugated cobalt polyphthalocyanine is prepared via a facile microwave heating method. Due to the crosslinked network, it is intrinsically elastic and has improved chemical, physical, and mechanical stability. Electrochemical measurements show that cobalt polyphthalocyanine facilitates the reversible formation and decomposition of Li2CO3, and therefore enables high‐performance Li–CO2 batteries with large areal capacity and impressive cycling performance. In addition, the elastic and reprocessable property of the polymeric catalyst renders it possible to fabricate flexible batteries.
Can members’ WeChat engagement affect relational outcomes in community‐supported agriculture? Empirical evidence from China
Authors: Tan Si , Chen Weiping 
Published: November 2018

AbstractMembers’ offline engagement is commonly believed to affect the producer–member relationship in community‐supported agriculture, however, little research focuses on engagement in the online context. Using qualitative data of 24 members and quantitative data of 279 members from China, this study uses a sequential exploratory mixed‐method design to explore the impact of members’ WeChat engagement on relational outcomes. The findings indicate that WeChat engagement positively affects four relational outcomes: Service satisfaction, word of mouth, social bonds, and commitment. In addition, those four relational outcomes are not equally influenced by WeChat engagement. The greatest impact is on commitment, while the lowest is on service satisfaction. Furthermore, multigroup analysis results suggest that gender moderates the relationship between WeChat engagement and commitment.
Iron homeostasis in pregnancy and spontaneous abortion
Authors: Guo Yifan , Zhang Na , Zhang Daoqiang , Ren Quanzhong , Ganz Tomas , Liu Sijin , Nemeth Elizabeta 
Published: November 2018

AbstractDuring pregnancy, iron requirements are increased to support maternal erythropoietic expansion and fetal growth and development. To meet these requirements, dietary iron absorption increases, and available iron stores are mobilized. These adjustments are thought to be in large part mediated by the iron‐regulatory hormone hepcidin, which controls the concentrations of ferroportin, the sole exporter of iron into the extracellular fluid and blood plasma. Hepcidin regulation of iron availability during healthy and abnormal pregnancies is not well understood. In our cross‐sectional study, we compared hepcidin, iron and hematological parameters between nonpregnant control women, healthy pregnant women in the first and second trimester, and women with spontaneous abortion in the first trimester. We found that in healthy pregnancy, hepcidin increased in the first trimester compared with nonpregnant women, but then decreased during the second trimester. The second trimester hepcidin levels decreased despite stable serum iron concentrations, suggesting active suppression of hepcidin, presumably to enhance iron availability as iron demand increases. In women with spontaneous abortion during the first trimester, hepcidin, serum iron, and ferritin concentrations were all increased compared with the first trimester healthy pregnancy. Although the specific mechanisms remain to be determined, our findings demonstrate that maternal hepcidin is regulated by signals related to the progression of pregnancy, and that pregnancy loss is associated with profound changes in maternal iron metabolism. These observations highlight the existence of fetoplacental signals that modulate maternal iron homeostasis.
Highly Efficient Rhodium‐Catalyzed Oxindole‐Directed Oxidative Heck‐Type Reaction of N‐Aryloxindoles with Alkenes
Authors: Li Wei‐Huan , Li Chao , Dong Lin 
Published: November 2018

AbstractRhodium(III)‐catalyzed oxindole‐directed oxidative Heck‐type olefination reactions of N‐aryloxindoles and olefins represent an efficient approach for the construction of C−C bond. It offers a straightforward and atom‐economical method for the synthesis of functionalized oxindole alkenylation derivatives in moderate to excellent yields.