bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved prospective risk analysis for clinical laboratories compensated for the throughput in processes
Authors: Janssens Pim M.W. , van der Horst Armando 
Published: May 2018

Abstract

Background:
Practical application of prospective risk analysis (PRA) in clinical laboratories should reflect processes as they are carried out, while making the PRA results obtained from different processes comparable. This means that not only STAT and standard testing and testing for critical and less critical parameters should be distinguished (as published), but also that the throughput in processes and process steps should be taken into account.

Methods:
Building on our previously published PRA, a method was developed to compensate for the throughput in processes and process steps. A factor T, related to the actually observed throughput, was introduced in the risk score calculation. Introduction of this compensation factor leads to different overall risk scores. The criteria by which the risk scores are evaluated were modified accordingly.

Results:
Introduction of a factor in the PRA to compensate for throughput leads to a change in the risk score for various conceivable failures in process steps. As compared to the PRA in which no compensation for throughput is made, in a process with low throughput the risk score for various conceivable failures in process steps comes out higher after introduction of the compensation factor, while in a process with high throughput various risk scores come out lower.

Conclusions:
Introduction of a factor to account for the throughput in a process (and process steps) leads to an improved, more realistic PRA, the results of which makes the risk scores of different processes (and process steps) better comparable to each other.
Excretion of Calcium, Phosphorus, Magnesium and Sodium in Lactating Sows
Authors: Novotný J. , Reichel P. , Kósa B. , Šipoš D. 
Published: May 2018

Abstract
The aim of this study was to evaluate the excretion of calcium (Ca), phosphorus (P), magnesium (Mg) and sodium (Na) via milk, urine and faeces during the lactation period of sows. Six clinically healthy lactating sows (crossbreed Large White × Landrace) were selected for these experiments and were housed in standard conditions and fed with commercially prepared dry mixture for this category of sows. The blood serum, milk, urine and faecal samples were collected on the 7th, 14th, 21st, and 28th day of lactation. During four weeks of lactation, we recorded the relatively stable and physiological concentrations of Ca, P, Mg and Na in blood serum. The analysis of the sow’s milk showed the highest concentration of Ca and P at the end of lactation, while the highest concentration of Mg and Na was observed on the 7th lactation day. The following macro-mineral excretion was recorded in urine: 98.83-194.00 mg.l-1 for Ca; 11.88- 53.09 mg.l-1 for P; 171.67-344.05 mg.l-1 for Mg; and 56.50-74.83 mg.l-1 for Na; and in the faeces, 1824.5- 3045.5 mg.kg-1 for Ca; 1566.93-2483.2 mg.kg-1 for P; 1916.2-2505.2 mg.kg-1 for Mg; and 516.8-748.2 mg. kg-1 for Na.
Revisiting the Role of the EU Judiciary as the Stronghold for the Protection of Human Rights while Countering Terrorism
Authors: Riccardi Alice 
Published: May 2018

AbstractThis article revisits the response of the European Union (EU) to the challenges posed by anti-terrorist smart sanctions regimes to fundamental rights, vis-à-vis recent legal developments. Following the Kadi saga, many authors defined the EU judicature as the bastion of the rule of law against executive powers. From the perspective of the Council of the EU, instead, Kadi caused a tremor. The EU courts did not only declare that anti-terrorist sanctions could be reviewed: they also affirmed that such review is in principle full, thus extended to all information substantiating sanctions, irrespective of whether covered by secrecy. In this respect, the European Court of Justice established that it is a task of the judiciary to accommodate security considerations militating against the disclosure of intelligence in court and the right to a fair trial. However, through legal instruments adopted in late 2016, the EU seems to be backing off from these settled principles. To test such assumption, the article proceeds in three steps. Firstly, it outlines the contours of the UN Security Council anti-terrorist sanctions regime, pinpointing the characteristics that make such regime problematic with respect to fair trial rights. Secondly, it surveys the development of EU courts’ case-law on secret evidence. Thirdly, it investigates whether the new legal instruments adopted by EU institutions adhere to the principles enshrined in said EU courts’ decisions, or rather represent a departure from consolidated due process rights.
Positioning stability improvement with inter-system biases on multi-GNSS PPP
Authors: Choi Byung-Kyu , Yoon Hasu 
Published: May 2018

Abstract
The availability of multiple signals from different Global Navigation Satellite System (GNSS) constellations provides opportunities for improving positioning accuracy and initial convergence time. With dual-frequency observations from the four constellations (GPS, GLONASS, Galileo, and BeiDou), it is possible to investigate combined GNSS precise point positioning (PPP) accuracy and stability. The differences between GNSS systems result in inter-system biases (ISBs). We consider several ISB values such as GPS-GLONASS, GPS-Galileo, and GPS-BeiDou. These biases are compliant with key parameters defined in the multi-GNSS PPP processing. In this study, we present a unified PPP method that sets ISB values as fixed or constant. A comprehensive analysis that includes satellite visibility, position dilution of precision, position accuracy is performed to evaluate a unified PPP method with constrained cut-off elevation angles. Compared to the conventional PPP solutions, our approach shows more stable positioning at a constrained cut-off elevation angle of 50 degrees.
Cross Check of the Tax Base in Serbia – Informative Tax Return Sample
Authors: Raonić Ivan , Vasić Zoran , Pejović Igor 
Published: May 2018

Abstract
The tax system of the Republic of Serbia is characterized by a very low level of income taxation. It is a particularly acute problem in cross-checking the tax base. The legislature tried to solve this problem by the introduction of the informative tax return (IPP). The problem is even greater because the situations encountered have not been analysed in science and tax theory, and very often have not been covered by applicable laws. A specific challenge for the tax authorities represent taxpayers whose incomes are primarily realized abroad (usually persons from the world of entertainment). This paper describes the basic forms of tax offences characteristic of income tax evasion and discusses how to solve them, with a particular focus on the implementation of cross-checking the tax base.
Association of Bax Expression and Bcl2/Bax Ratio with Clinical and Molecular Prognostic Markers in Chronic Lymphocytic Leukemia
Authors: Vucicevic Ksenija , Jakovljevic Vladimir , Colovic Natasa , Tosic Natasa , Kostic Tatjana , Glumac Irena , Pavlovic Sonja , Karan-Djurasevic Teodora , Colovic Milica 
Published: May 2018

Summary
Background: In chronic lymphocytic leukemia (CLL), in vivo apoptotic resistance of malignant B lymphocytes results, in part, from the intrinsic defects of their apoptotic machinery. These include genetic alterations and aberrant expression of many apoptosis regulators, among which the Bcl2 family members play a central role.
Aim: The aim of this study was to investigate the association of pro-apoptotic Bax gene expression and Bcl2/Bax ratio with the clinical features of CLL patients as well as with molecular prognostic markers, namely the mutational status of rearranged immunoglobulin heavy variable (IGHV) genes and lipoprotein lipase (LPL) gene expression.
Methods: We analyzed the expression of Bax mRNA and Bcl2/Bax mRNA ratio in the peripheral blood mononuclear cells of 58 unselected CLL patients and 10 healthy controls by the quantitative reverse-transcriptase polymerase chain reaction.
Results: We detected significant Bax gene overexpression in CLL samples compared to non-leukemic samples (p=0.003), as well as an elevated Bcl2/Bax ratio (p=<0.001). Regarding the association with prognostic markers, the Bcl2/Bax ratio showed a negative correlation to lymphocyte doubling time (r=−0.307; p=0.0451), while high-level Bax expression was associated with LPL-positive status (p=0.035). Both the expression of Bax and Bcl2/Bax ratio were higher in patients with unmutated vs. mutated IGHV rearrangements, but this difference did not reach statistical significance.
Conclusions: Our results suggest that dysregulated expression of Bcl2 and Bax, which leads to a high Bcl2/Bax ratio in leukemic cells, contributes to the pathogenesis and clinical course of CLL.
γ-Al2O3:Ce3+Cu2+ as a phosphor material; DFT+U and experimental approach
Authors: Mulwa Winfred Mueni , Dejene Francis Birhanu 
Published: May 2018

AbstractThe γ-Al2O3and Ce3+Cu2+-doped γ-Al2O3powders have been synthesized by sol-gel method. Phases of the synthesized powders were characterized with X-ray diffraction. Morphological analysis and elemental composition of the samples were determined by scanning electron microscopy, high-resolution transmission electron microscopy and energy dispersive X-ray spectroscopy. Luminescence characterizations have been used to study the synthesized samples.Ab initiocalculations by the use of local density approximation with the HubbardUcorrelation were used to compute the structural, electronic and optical properties of γ-Al2O3and Al2O3:Ce3+Cu2+. The results indicate that the particle size and morphology of the samples depend on the concentration of the dopants. In comparison with undoped γ-Al2O3sample, the intensities of emission peaks at 430 and 458 nm of Ce3+Cu2+-doped γ-Al2O3powders have been enhanced. This shows that, increasing Ce3+and Cu2+concentration causes an increase in the number of emitting ions which is expected in order to increase the number of applications of γ-Al2O3:Ce3+Cu2+composite powders. The photoluminescence spectrum detected at$\lambda$ex = 253 nm shows a new peak located at 549 nm due to Cu2+ions. This was confirmed computationally when the Ce_4f and Ce_5d states are found in the conduction band while the Cu_4p state was found at conduction band minimum and Cu_3d state at valence band maximum. This location of states showed there is no possible luminescence from the Ce3+ions. The only possible luminescence was due to transition from Cu_4p to Cu_3d states.
Critical ESP Textbook Evaluation: The Case of Visual Arts Textbook
Authors: Karimnia Amin , Jafari Fatemeh Mohammad 
Published: May 2018

Summary
Since textbooks are one of the integral components of the learning process, their evaluation is important to improve their correspondence to the learners’ needs and goals. Particularly, in societies in which English is used as a foreign language, ESP textbooks play a crucial role in developing students’ skills of English in job-related situations. The present paper discusses the quality of ESP textbooks by performing a case study of an English for Specific Purposes (ESP) textbook “English for the students of Visual Arts (Painting, Graphics, & Sculpture)” developed and published by SAMT as the pioneer in developing ESP textbooks in Iranian academic setting. The study tries to investigate the overall suitability and pedagogical value of the ESP textbook and the features which make it distinguishable among its global counterparts. The study was carried out by drawing on a model proposed by McDonough and Shaw (2003), with an intention to evaluate the present quality of the Visual Arts ESP textbook critically. Both visual and content-based aspects of the book were thoroughly evaluated to identify their general pedagogical value by using the method of qualitative descriptive analysis. In that way, the Visual Arts textbook was analysed on the basis of the framework and guidelines suggested in the available checklist. In addition, semi structured interviews with graduate students, English instructors, subjectspecific instructors, and experts in Visual Arts Courses such as Painting were performed to clarify their opinions about the need for ESP and to analyze their perceptions of English language in general and English for special purposes in particular. The findings of the present study have revealed that there is a fundamental necessity for revision and development of future ESP textbooks in Iranian context. Moreover, the findings imply that traditional materials and frameworks are not responsive to students’ needs and genre knowledge in majors of the Visual Arts.
Conversion of human adipose derived stem cells into endothelial progenitor cells
Authors: Tran Van Hong , Nguyen Hoa Trong , Pham Phuc Van 
Published: May 2018

Introduction: Endothelial cells (ECs) or endothelial progenitor cells (EPCs) are essential cells for blood vascular regeneration and vascular tissue engineering. However, the source of EPCs are limited. Indeed, these cells only existence with low rate at some tissues such as bone marrow, umbilical cord blood and peripheral blood. This study aimed to produce EPCs from direct reprogramming of adipose tissue-derived mesenchymal stem cells (ADSCs) by ETV2 transfection in vitro.
Methods: ADSCs were isolated according to the published works. They were confirmed as mesenchymal stem cells (MSCs) with some characteristics included expression of CD44, CD73, CD90, negative of CD14, CD45, and HLA-DR; in vitro differentiation into adipocytes, and osteoblasts. ETV-2 mRNA was in vitro produced by commercial kit. ETV-2 mRNA molecules were transfected into ADSCs by Fugenes and Lipofectamine agents. These transfected cells were evaluated the expression of EPC properties included expression of CD31, VEGFR-2 in the cell surface by flow cytometry, immunocytochemistry, and in vitro vessel formation in the Matrigel.
Results: The results showed that ETV-2 could transform the ADSCs from mesenchymal cell phenotype into endothelial cell phenotype with 10% transfected ADSCs expressing the CD31 in their surface, they also could form the vessel structure in vitro.
Conclusion: Although the low efficacy of direct reprogramming, this study gave the new strategy to produce EPCs from the favorite cell sources as ADSCs.
Expression of CD34 marker in the adipose tissue derived stem cells
Authors: Pham Phuc Van , Vu Ngoc Bich , Tran Van Hong 
Published: May 2018

Introduction: Adipose-derived stem cells (ADSCs) are considered as mesenchymal stem cells (MSCs). Indeed, they display all characteristics of MSCs that compliant with the minimal criteria of MSCs suggested by Domonici et al. (2006). However, some recent studies showed that ADSCs contain the subpopulation that was positive with CD34 marker – a marker of hematopoietic stem cells. This study aimed to analyze and determine the expression of CD34 marker in ten samples of ADSCs obtained from 10 donors.
Methods: All ADSC samples were isolated and expanded according to the published previous protocols. They were confirmed as the MSCs with some markers and differentiation potential, excepting the CD34 expression. Then they were cultured and analyzed the expression of CD34 by flow cytometry at passage 3, 5, 7 and 9.
Results: The results showed that expression of CD34 in ADSCs was different between donors and their passages that accounted from 1.21% to 23.38%.
Conclusion: These results suggested that ADSCs are not ‘truly” MSCs like MSCs from bone marrow.
Safety II Behavior in a Pediatric Intensive Care Unit
Authors: Merandi Jenna , Vannatta Kathryn , Davis J. Terrance , McClead Richard E. , Brilli Richard , Bartman Thomas 
Published: May 2018

BACKGROUND AND OBJECTIVE:
Safety I error elimination concepts are focused on retrospectively investigating what went wrong and redesigning system processes and individual behaviors to prevent similar future occurrences. The Safety II approach recognizes complex systems and unpredictable circumstances, mandating flexibility and resilience within systems and among individuals to avoid errors. We hypothesized that in our high-complexity and high-risk PICU, Safety II concepts contribute to its remarkably low adverse drug event rate. Our goal was to identify how this microsystem enacts Safety II.

METHODS:
We conducted multidisciplinary focus group sessions with PICU members using nonleading, open-ended questions to elicit free-form conversation regarding how safety occurs in their unit. Qualitatively analyzing transcripts identified system characteristics and behaviors potentially contributing to low adverse drug event rates in PICU. Researchers skilled in qualitative methodologies coded transcripts to identify key domains and common themes.

RESULTS:
Four domains were identified: (1) individual characteristics, (2) relationships and interactions, (3) structural and environmental characteristics, and (4) innovation approaches. The themes identified in the first 3 domains are typically associated with Safety I and adapted for Safety II. Themes in the last domain (innovation approaches) were specific to Safety II, which were layered on Safety I to improve results under unusual situations.

CONCLUSIONS:
Safety II behavior in this unit was based on strong Safety I behaviors adapted to the Safety II environment plus innovation behaviors specific to Safety II situations. We believe these behaviors can be taught and learned. We intend to spread these concepts throughout the organization.
Super-replication of European Options with Convex Payoff under Proportional Transaction Costs
Authors: Rygiel Agnieszka 
Published: May 2018

The paper examines the super-replication of contingent claims in a discrete time financial market with proportional transaction costs. The sole assumption on stock price dynamics is that the returns are bounded. The class of path-dependent European options with nonnegative convex payoff functions is considered. It is proved that the pricing of this type of options can be studied through the pricing of a suitable binomial model. As a consequence, it is shown that the pricing algorithm, which is essentially a dynamic programming procedure on a tree, can be used when the set of possible scenarios is not finite.
Porównanie bayesowskich modeli Copula-AR(1)-GARCH(1,1) z asymetrycznością rozkładów warunkowych
Authors: Mokrzycka Justyna 
Published: May 2018

The main aim of the paper is to formally assess the relative explanatory power of competing bivariate Copula-AR-GARCH models with symmetric and skewed Student t distributions on the example of data from the The Warsaw Stock Exchange. The subject of comparison were 22 Copula-AR(1)-GARCH (1,1) models, which differed in assumptions on the copula and the occurrence of skewness in marginal distributions. In the context of the models under consideration, Monte Carlo Important Sampling methods were used to estimate the characteristics of a posteriori distribution and the marginal density of the observation matrix. For analysing empirical data, a posteriori models turned out to be ones more likely to have symmetrical conditional t-Student distributions. For the logarithmic daily growth rates of the two sub-indicies of the stock index WIG, the highest a posteriori probability was obtained by the Clayton-Gumbel copula model. The use of the skewed Student's t-distribution did not improve the explanatory power of the Copula-GARCH models.
Propuesta de intervención en familiares de niños con TEA desde ACT para mejorar la convivencia familiar y escolar
Authors: Lozano-Segura Mª Carmen , Manzano-León Ana , Casiano Yanicelli Carla , Aguilera-Ruíz Cristian 
Published: May 2018

El diagnóstico de autismo de un hijo llega al seno de la familia con dificultad y emociones encontradas. Se inicia una etapa en la que se ponen en marcha gran variedad de recursos para hacer que el desarrollo de la persona diagnosticada con Trastorno del Espectro Autista se asemeje lo más posible a una evolución neurotípica.Objetivos: El primer objetivo de este trabajo es hacer una búsqueda bibliográfica de artículos que versen sobre los Programas para tratar las dificultades que encuentran los padres o familias a la hora de educar o convivir y enseñar a convivir en casa y en escuelas a sus hijos o familiares, así como estrategias de intervención para tratar los obstáculos existentes en familiares de niños con diagnóstico de Trastorno del Espectro Autista (TEA). Como segundo objetivo se pretende realizar una propuesta de intervención con familias de niñosdiagnosticados con TEA desde el marco de la Terapia de Aceptación y Compromiso basada en los resultados encontrados.Metodología: Se ha realizado una revisión sistemática de artículos científicos consultando lasbases de datos Web of Science, Scopus e INDAGA. Los materiales han sido restringidos por fecha de publicación (2000/2017) y se han buscado en idioma español e inglés. Se han revisado resúmenes/abstracts y se han leído en profundidad los artículos seleccionados así como todos los artículos con resultados empíricos y teóricos de relevancia para esta revisión.Resultados: Como resultado de la búsqueda sistemática se ha propuesto una intervenciónen familias de niños con diagnóstico de TEA desde el marco de la Terapia de Aceptación y Compromiso.Conclusiones: Se ha comprobado que son muchas las líneas desde las que se proponen intervenciones para familias de niños diagnosticados con TEA, pero son las basadas en Terapia de Aceptación y Compromiso (ACT) las que mayores beneficios reportan en la mejora de la convivencia en casa y la posterior integración y convivencia del niño en el aula. Por ello la propuesta de intervención que se propone está basada en esta terapia de tercera generación.
Las actitudes del alumnado universitario frente a las personas con trastorno mental
Authors: Medina- Mesa Yolanda , Martínez - García Concha , Morales - Sánchez Lucia , Gil-Olarte Paloma 
Published: May 2018

La enfermedad mental es un problema de salud a nivel mundial que afecta a una de cada cuatro personas. A pesar de su elevada incidencia, existe una fuerte discriminación social sobre estos enfermos (OMS, 2004). Diversos profesionales se encuentran en su desempeño diario situaciones de interacción con estos pacientes pudiendo actuar como perpetuadores del estigma si muestran actitudes negativas de miedo y hostilidad (Roos y Goldner, 2009). Asimismo, el contacto con estos enfermos mentales condicionará las actitudes hacia la propia enfermedad. El objetivo de este estudio es conocer las actitudes hacia los enfermos mentales de los futuros profesionales de Ciencias de la Salud, en comparación con el alumnado de otras ramas de conocimiento, y explorar si mantener contacto con estos enfermos puede modificar dicha actitud. Se administró el cuestionario “Opiniones sobre la enfermedad mental” (Ozamiz, 1980) a 820 estudiantes (70,37% mujeres y 29,63% hombres) de diferentes titulaciones de Ciencias de la Salud y Ciencias Sociales y Jurídicas. Esta escala informa sobre la Actitud general y 5 subdimensiones (Negativismo, Etiología social, Autoritarismo, Restrictividad y Prejuicio), obteniendo una fiabilidad superior a .7 en Negativismo y Etiología Social. Los resultados indican que los estudiantes de Ciencias de la Salud muestran menores niveles de Negativismo hacia el enfermo mental que el alumnado de Ciencias Sociales y Jurídicas, independientemente del contacto mantenido. Además, los estudiantes que manifiestan haber tenido contacto con estos enfermos presentan menores niveles de Negativismo, no diferenciándose de forma estadísticamente significativa ni en la Actitud general, ni en Etiología social, con independencia de la titulación cursada. Estos resultados parecen indicar que una actitud negativa hacia el enfermo mental es menor entre el alumnado de Ciencias de la Salud en comparación con las Ciencia Sociales y Jurídicas, y entre los que han mantenido contactos con enfermos mentales.