bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of astrometric microlensing events from Gaia DR2 proper motions
Authors: Klüter J. , Bastian U. , Demleitner M. , Wambsganss J. 
Published: October 2018

Context. Astrometric gravitational microlensing is an excellent tool to determine the mass of stellar objects. Using precise astrometric measurements of the lensed position of a background source in combination with accurate predictions of the positions of the lens and the unlensed source it is possible to determine the mass of the lens with an accuracy of a few percent.
Aims. Making use of the recently published Gaia Data Release 2 (DR2) catalogue, we want to predict astrometric microlensing events caused by foreground stars with high proper motion passing a background source in the coming decades.
Results. We selected roughly 148 000 high-proper-motion stars from Gaia DR2 with μtot > 150 mas yr−1 as potential lenses. We then searched for background sources close to their paths. Using the astrometric parameters of Gaia DR2, we calculated the future positions of source and lens. With a nested-intervals algorithm we determined the date and separation of the closest approach. Using Gaia DR2 photometry we determined an approximate mass of the lens, which we used to calculate the expected microlensing effects.
Conclusions. We predict 3914 microlensing events caused by 2875 different lenses between 2010 and 2065, with expected shifts larger than 0.1 mas between the lensed and unlensed positions of the source. Of those, 513 events are expected to happen between 2014.5 and 2026.5 and might be measured by Gaia. For 127 events we also expect a magnification between 1 mmag and 3 mag.
Stellar systems in the direction of Pegasus I
Authors: González Nélida M. , Smith Castelli Analía V. , Faifer Favio R. , Escudero Carlos G. , Cellone Sergio A. 
Published: October 2018

Context. In spite of the numerous studies of low-luminosity galaxies in different environments, there is still no consensus about their formation scenario. In particular, a large number of galaxies displaying extremely low surface brightnesses have been detected in recent years and the nature of these objects is still under discussion.
Aims. In order to enlarge the sample of known low-surface-brightness (LSB) galaxies and to try to provide clues about their nature, we report the detection of eight such objects ( μeff,g′≃ 27 mag arcsec−2) towards the group of galaxies Pegasus I. They are located, in projection, within a radius of ∼200 kpc in the very center of Pegasus I, close to the dominant elliptical galaxies NGC 7619 and NGC 7626.
Methods. We analyzed deep, high-quality GEMINI-GMOS images with ELLIPSE within IRAF in order to obtain their brightness profiles and structural parameters. We also fit Sérsic functions to these profiles in order to compare their properties with those of typical early-type galaxies.
Results. Assuming that these galaxies are at the distance of Pegasus I, we have found that their sizes are intermediate among similar objects reported in the literature. In particular, we found that three of these galaxies can be classified as ultra-diffuse galaxies and a fourth one displays a nucleus. The eight new LSB galaxies show significant color dispersion around the extrapolation towards faint luminosities of the color–magnitude relation defined by typical early-type galaxies. In addition, they display values of the Sérsic index below 1 (concave brightness profiles in linear scale), in agreement with values obtained for LSB galaxies in other environments.
Conclusions. We show that there seems to be a bias effect in the size distributions of the detected LSBs in different environments, in the sense that more distant groups/clusters lack small r
eff objects, while large systems are not found in the Local Group and nearby environments. While there may be an actual shortage of large LSB galaxies in low-density environments like the Local Group, the non-detection of small (and faint) systems at large distances is clearly a selection effect. As an example, LSB galaxies with similar sizes to those of the satellites of Andromeda in the Local Group will be certainly missed in a visual identification at the distance of Pegasus I.
Calcific deposit needling in combination with extracorporeal shock wave therapy (ESWT): A proposed treatment for supraspinatus calcified tendinopathy
Authors: Pakos Emilios , Gkiatas Ioannis , Rakkas Georgios , Papadopoulos Dimitrios , Gelalis Ioannis , Vekris Marios , Korompilias Anastasios 
Published: October 2018

Background: Calcified tendinopathy of the rotator cuff is one of the most common conditions concerning the shoulder pathology. It is characterized by a reactive calcification that affects the tendons being part of the rotator cuff. The reported prevalence varies from 2.7% to 22%. Most of the patients can be treated effectively with non-operative measures such as anti-inflammatory drugs, subacromial injection of steroid, physiotherapy, extracorporeal shock wave therapy (ESWT) and needle aspiration irrigation. Results of a treatment combining some of these methods have not been reported.
Objectives: The purpose of this study is to present the radiological as well as the clinical results of our proposed protocol which combines drilling of the calcium deposits with xylocaine under ultrasound guidance, with a specific program of physiotherapy for 1 month without the use of NSAIDs.
Methods: Sixty-six consecutive patients (68 shoulders) were treated for calcified tendinitis of supraspinatus, which was diagnosed clinically and radiologically, with needle drilling using xylocaine under ultrasound guidance. After the drilling the patient followed a physiotherapy protocol with ESWT which included five visits within a month. After the end of the physiotherapy, the patients were evaluated clinically and radiologically. The Visual Analogue Scale (VAS) for pain and the Disabilities of the Arm, Shoulder, and Hand (DASH) score were measured before and after the end of the therapy.
Results: All the patients showed clinical improvement of the symptoms at the follow-up. The mean VAS score showed improvement from 8.1 to 3.3 whereas the mean DASH score was 27 and after the end of the therapy 5. Radiologically all but one calcific deposits were disappeared.
Conclusions: The ultrasound-guided drilling of the calcific deposit using xylocaine, in combination with physiotherapy using ESWT provides a reliable alternative treatment for the calcific tendinitis of the supraspinatus
Komplikationen nach Septumplastik analysiert
Authors: Schrom Thomas 
Published: October 2018

Dąbrowska-Bień J et al. Complications in septoplasty based on a large group of 5639 patients. Eur Arch Otorhinolaryngol 2018; 275: 1789–1794
In der Literatur fehlen Angaben zu Komplikationen nach alleiniger Septumplastik sowie der Kombination von Septumplastik mit Nasenmuschelreduktion in großen
Populationen. Eine Arbeitsgruppe aus Warschau versuchte Komplikationen bei der Septumplastik zu bestimmen und die Inzidenz in Abhängigkeit von der
Operationstechnik zu analysieren.
Mundhöhlenkarzinom: Optionen zum Erhalt der Unterkieferspeicheldrüse
Authors: Jecker Peter 
Published: October 2018

Cakir Cetin A et al. Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma. J Laryngol Otol 2018; 132:
446–451
Ärzte der medizinischen Fakultät der Universität in Izmir untersuchten Inzidenz und relevante Faktoren die mit der Beteiligung Unterkieferspeicheldrüse am
Mundhöhlenkarzinom assoziiert sind. Insbesondere deswegen, um herauszufinden, ob in einem frühen Stadium des Plattenepithelkarzinoms der Mundhöhle die
Möglichkeit besteht, die Unterkieferspeicheldrüse zu erhalten.
Statement of the Uterus Committee of the Gynaecological Oncology Working Group (AGO) on the PORTEC-3 study
Authors: Emons Günther , Tempfer Clemens , Battista Marco , Mustea Alexander , Vordermark Dirk 
Published: October 2018

AbstractThe data on the adjuvant therapy of endometrial cancer (EC) are inconsistent. Recent studies of this topic such as PORTEC-3, GOG-258 and GOG-249 investigated the value of adjuvant radiotherapy, adjuvant chemotherapy and combined adjuvant chemoradiotherapy followed by chemotherapy in patients with endometrial cancer and an increased risk of recurrence. With this statement, the Uterus Committee of the Gynaecological Oncology Working Group (AGO) wishes therefore to interpret the new data and discuss them against the background of the new S3 guideline “Diagnosis, treatment and follow-up of patients with endometrial cancer”.
Management of Urethral Lesions and Urethrovaginal Fistula Formation Following Placement of a Tension-Free Suburethral Sling: Evaluation From a University Continence and Pelvic Floor Centre
Authors: Schöller Dorit , Brucker Sara , Reisenauer Christl 
Published: October 2018

Abstract
Introduction The complication of tape erosion in the urethra following placement of a retropubic (TVT) or transobturator (TOT) tension-free suburethral vaginal sling or an accidental iatrogenic transurethral tape position can result in the formation of a urethrovaginal or vesicovaginal fistula. The objective of the investigation is the evaluation of the management of such rare complications.
Patients and Methods Retrospective analysis of 14 patients who were treated for a urethral lesion or urethrovaginal fistula formation status post TVT/TOT placement between June 2011 and February 2018 in the Tübingen University Department of Gynaecology.
Results As surgical therapy, 57.1% (n = 8) cases underwent vaginal fistula closure using a Martius flap of the labium majus and in 21.4% (n = 3) using a vaginal rotation skin flap. In 21.4% (n = 3), exclusively vaginal suture reconstruction of the urethra following excision of the tape running transurethrally or tape erosion was performed. 50% (n = 7) of the patients had lasting continence postoperatively without any further need for therapy. In 28.6% (n = 4), there was ongoing stress urinary incontinence, in 21.4% (n = 3) mixed urinary incontinence. Six of the 7 patients with persistent incontinence underwent new placement of a tension-free suburethral retropubic sling (TVT) an average of 8.8 months (5 – 13 months) postoperatively which was uncomplicated in all patients and achieved satisfactory continence. The 3 patients with mixed urinary incontinence and persistent urgency components additionally received anticholinergic medication. During the time period investigated, there were no long-term complications, in particular no recurrent fistulas.
Conclusion The rare but relevant complications of a urethral erosion, transurethral tape position or urethrovaginal fistula formation status post TVT/TOT placement can be successfully managed via vaginal surgery. Persistent postoperative urinary incontinence with the need for a two-phase repeat TVT placement following sufficient wound healing must be preoperatively clarified.
Needle-based confocal laser endomicroscopy of pancreatic cystic lesions: a prospective multicenter validation study in patients with definite diagnosis
Authors: Napoleon Bertrand , Palazzo Maxime , Lemaistre Anne-Isabelle , Caillol Fabrice , Palazzo Laurent , Aubert Alain , Buscail Louis , Maire Frédérique , Morellon Blandine Mialhe , Pujol Bertrand , Giovannini Marc 
Published: October 2018

Abstract
Background Needle-based confocal laser endomicroscopy (nCLE) enables observation of the inner wall of pancreatic cystic lesions (PCLs) during an endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). This study prospectively evaluated the diagnostic performance of nCLE for large, single, noncommunicating PCLs using surgical histopathology or EUS-FNA cytohistopathology as a reference diagnosis.
Methods From April 2013 to March 2016, consecutive patients referred for EUS-FNA of indeterminate PCLs without evidence of malignancy or chronic pancreatitis were prospectively enrolled at five centers. EUS-FNA and nCLE were performed and cystic fluid was aspirated for cytohistopathological and carcinoembryonic antigen (CEA) analysis. The diagnostic performance of nCLE was assessed against the reference standard and compared with that of EUS and CEA. This study was registered on ClinicalTrials.gov (NCT01563133).
Results 206 patients underwent nCLE and 78 PCLs (mean size 40 mm, range 20 – 110 mm) had reference diagnoses (53 premalignant and 25 benign PCLs). Post-procedure pancreatitis occurred in 1.3 % of the patients. nCLE was conclusive in 71 of the 78 cases (91 %). The sensitivies and specifities of nCLE for the diagnosis of serous cystadenoma, mucinous PCL, and premalignant PCL were all ≥ 0.95 (with 95 % confidence interval from 0.85 to 1.0). The AUROC was significantly larger for nCLE than for CEA or EUS.
Conclusions nCLE had excellent diagnostic performance that surpassed that of CEA and EUS for the diagnosis of large, single, noncommunicating PCLs. The nCLE procedure should be considered in patients with indeterminate PCLs to ensure a more specific diagnosis.
Lungenszintigraphie (Version 3)
Authors: Schümichen Carl , Schmidt Matthias , Krause Thomas 
Published: October 2018

ZusammenfassungIn der aktualisierten und erweiterten S1-Leitlinie zur Lungenszintigraphie werden die Vorzüge der Methode beim Nachweis der akuten Lungenembolie (LE) in der Lungenperipherie (subsegmentale LE), bei subakuten und chronischen Grunderkrankungen der Lunge, sowie beim Nachweis der chronischen LE (CTEPH) herausgestellt. Methode der Wahl ist die Ventilations/Perfusions(V/P)-SPECT oder V/P-SPECT/CT mit nochmals gesteigerter Spezifität. Aufgrund der hohen Sensitivität wird, um eine Übertherapie zu vermeiden, ein Schwellenwert eingeführt (V/P-mismatch in mindestens einem Segment oder zwei Subsegmenten). Im Falle eines veränderten Therapieverhaltens (nur Observation anstelle Antikoagulation) kann der Schwellenwert entfallen. Zur klinisch-therapeutischen Wertigkeit von subsementalen LE werden neue Daten präsentiert, die Kapitel offene Fragen wurden erweitert. Die weiteren Indikationen für V/P-SPECT (Nebendiagnosen, Anomalien der Lungenperfusion, Voraussage der postoperativen Lungenfunktion) werden mit neueren Daten hinterlegt.
Trisections of 4-manifolds with boundary
Authors: Castro Nickolas A. , Gay David T. , Pinzón-Caicedo Juanita 
Published: October 2018

Significance
Trisections are decompositions of 4D spaces (4-manifolds) into three pieces; these decompositions become both richer and more subtle when the 4-manifolds have 3D boundaries and even more subtle when there are multiple boundary components. Here, we discuss this setup and show how to turn a certain standard decomposition of a 4-manifold with boundary, a handle decomposition, into a diagram drawn on a surface that describes that 4-manifold and its trisection given certain boundary conditions.
Computing trisections of 4-manifolds
Authors: Bell Mark , Hass Joel , Rubinstein Joachim Hyam , Tillmann Stephan 
Published: October 2018

Significance
Algorithms that decompose a manifold into simple pieces reveal the geometric and topological structure of the manifold, showing how complicated structures are constructed from simple building blocks. This note describes a way to algorithmically construct a trisection, which describes a four-dimensional manifold as a union of three four-dimensional 1-handlebodies. The complexity of the 4-manifold is captured in a collection of curves on a surface, which guide the gluing of the 1-handlebodies. The algorithm begins with a description of a manifold as a union of pentachora or four-dimensional simplices. It transforms this description into a trisection.
Simplified broken Lefschetz fibrations and trisections of 4-manifolds
Authors: Baykur R. İnanç , Saeki Osamu 
Published: October 2018

Significance
As our world, with time included, is 4D, exploring similarities and differences of 4D spaces via maps and decompositions they admit leads to a better understanding of the universe we are living in. This article studies maps from 4D spaces to 2D ones. We illustrate how to modify such maps algorithmically to derive rather special maps that allow us to break 4D spaces into much simpler, much better-understood pieces. Our general methods are presented with a large variety of explicit constructions.
Paracrine costimulation of IFN-γ signaling by integrins modulates CD8 T cell differentiation
Authors: Krummel Matthew F. , Mahale Jagdish N. , Uhl Lion F. K. , Hardison Emily A. , Mujal Adriana M. , Mazet Julie M. , Weber Robert J. , Gartner Zev J. , Gérard Audrey 
Published: October 2018

SignificanceIFN-γ is an example of a pleiotropic cytokine that plays critical roles in promoting both protective immune responses and immunopathological processes. In response to this cytokine, cells activate a well-identified and conserved JAK/STAT signaling pathway that can still elicit distinct responses, even in the same cell type. How this outcome specificity is achieved remains largely unknown. We have found that IFN-γ regulates CD8 T cell differentiation through noncanonical pathways that are enabled by integrin costimulation of the STAT1 pathway. This leads to cooperative effects between activating cell types that is dictated by proximity. This study demonstrates the importance of cofactors and microenvironment in eliciting specific cytokine functions.
Nonequilibrium associative retrieval of multiple stored self-assembly targets
Authors: Bisker Gili , England Jeremy L. 
Published: October 2018

SignificanceMajor experimental research efforts have gone into investigating general principles governing self-assembly under nonequilibrium driving. However, in contrast to equilibrium scenarios, where the system tends to find local minima in the free-energy landscape, there is no equivalent theoretical framework for systems operating far from equilibrium. Inspired by many examples of nonequilibrium self-assembly in living systems, we set out to explore the added benefits achieved by nonequilibrium driving and identify distinctive collective phenomena that emerge in this regime. We demonstrate the interplay between the assembly speed, kinetic stability, and relative population of dynamical attractors, aiming to provide insights into nonequilibrium self-assembly processes and lay the foundations for understanding biomolecular cases as well as for designing examples.
Isolation and characterization of NY-ESO-1–specific T cell receptors restricted on various MHC molecules
Authors: Bethune Michael T. , Li Xiao-Hua , Yu Jiaji , McLaughlin Jami , Cheng Donghui , Mathis Colleen , Moreno Blanca Homet , Woods Katherine , Knights Ashley J. , Garcia-Diaz Angel , Wong Stephanie , Hu-Lieskovan Siwen , Puig-Saus Cristina , Cebon Jonathan , Ribas Antoni , Yang Lili , Witte Owen N. , Baltimore David 
Published: October 2018

Significance
T immune cells can be engineered to express tumor-specific T cell receptor (TCR) genes and thereby kill cancer cells. This approach—termed TCR gene therapy—is effective but can cause serious adverse events if the target is also expressed in healthy, noncancerous tissue. NY-ESO-1 is a tumor-specific antigen that has been targeted successfully and safely through TCR gene therapies for melanoma, synovial sarcoma, and myeloma. However, trials to date have focused exclusively on a single NY-ESO-1–derived epitope presented on HLA-A*02:01, limiting application to patients expressing that allele. In this work, we isolate TCRs that collectively recognize multiple NY-ESO-1–derived epitopes presented by multiple MHC alleles. We thereby outline a general approach for expanding targeted immunotherapies to more diverse MHC haplotypes.
Paratactic negation revisited
Authors: Salminen Jutta 
Published: October 2018

AbstractThis paper examines the phenomenon of paratactic negation (PN) by analyzing the usage of the Finnish verbepäillä(‘doubt’, ‘suspect’, ‘suppose’), which is associated with both inherent negation and negative evaluation. Paratactic negation refers to an overt negation in a complement clause of an inherently negative verb that results in a single negative reading. This analysis draws on previous research going back toJespersen (1917), in observing that the PN complement clause verbalizes the content of the activity that is expressed by the matrix verb. In this case, the verb of inherent negation does not have scope over the complement despite its negative semantics. This paper addresses the question of where and why content complements actually occur. The answer to this question is given by accounting for the differences of the content complements from more clearly subordinate target complements. It is shown that this distinction is related to verb semantics and conventionalized syntagmatic patterns. This is demonstrated by accounting for the differences of the content complements from more clearly subordinate target complements. On the basis of these results, the paper offers a refined definition of paratactic negation. This definition has two major implications: First, it suggests that a semantically non-vacuous PN may be a conventionalized pattern. Second, it leads us to reconsider the limits of PN and the definition of inherent negation.
Pointing to the body
Authors: Green Jennifer , Bauer Anastasia , Gaby Alice , Ellis Elizabeth Marrkilyi 
Published: October 2018

AbstractKinship plays a central role in organizing interaction and other social behaviors in Indigenous Australia. The spoken lexicon of kinship has been the target of extensive consideration by anthropologists and linguists alike. Less well explored, however, are the kin categories expressed through sign languages (notwithstanding the pioneering work of Adam Kendon). This paper examines the relational categories codified by the kin signs of four language-speaking groups from different parts of the Australian continent: the Anmatyerr from Central Australia; the Yolŋu from North East Arnhem Land; the Kuuk Thaayorre from Cape York and theNgaatjatjarra/​Ngaanyatjarrafrom the Western Desert. The purpose of this examination is twofold. Firstly, we compare the etic kin relationships expressed by kin signs with their spoken equivalents. In all cases, categorical distinctions made in the spoken system are systematically merged in the sign system. Secondly, we consider the metonymic relationships between the kin categories expressed in sign and the various parts of the body at which those signs are articulated.
Some pragmatic functions of conversational facial gestures1
Authors: Bavelas Janet , Chovil Nicole 
Published: October 2018

Abstract

Conversational facial gestures are not emotional expressions (Ekman, 1997). Facial gestures are co-speech gestures – configurations of the face, eyes, and/or head that are synchronized with words and other co-speech gestures. Facial gestures are the most frequent facial actions in dialogue, and the majority serve pragmatic (meta-communicative) rather than referential functions. A qualitative microanalysis of a close-call story illustrates three pragmatic facial gestures in their macro- and micro-context: (a) The narrator’s thinking faces (Goodwin & Goodwin, 1986) occurred as the narrator was getting started, and they accompanied verbal collateral signals of delay, such as “uh” or “um”. (b) The narrator pointed at his hand gestures with his head and eyes (Streeck, 1993), drawing the addressee’s attention to depictions that would later be crucial to the close call. (c) The meta-communicative functions of smiles included marking the narrator’s description of danger as ironic or humorous, hinting at key elements, and acknowledging errors.