bluuebunny/crossref_metadata_2025_split huggingface dataset:
GM-CSF– and IRF4-Dependent Signaling Can Regulate Myeloid Cell Numbers and the Macrophage Phenotype during Inflammation
Authors: Lee Ming-Chin , Lacey Derek C. , Fleetwood Andrew J. , Achuthan Adrian , Hamilton John A. , Cook Andrew D. 
Published: April 2019

AbstractStudies have demonstrated the importance of a GM-CSF→IFN regulatory factor 4 (IRF4)→CCL17 pathway, first identified in monocytes/macrophages, for arthritic pain and disease development. In this study, we further investigated the involvement of this new pathway in shaping the inflammatory response using the zymosan-induced peritonitis (ZIP) model. ZIP (8 mg of zymosan, i.p., day 0) was induced in C57BL/6 wild-type (WT), GM-CSF−/−, Irf4−/−, and Ccl17E/E mice. In comparison with WT mice, GM-CSF−/− and Irf4−/− mice had a reduced ZIP response, as judged by a reduced number of neutrophils and macrophages in the peritoneal cavity. Moreover, the phenotype of the ZIP macrophages was altered by a lack of GM-CSF or IRF4 (increased IL-10 secretion and Arg1 mRNA expression), with IRF4 levels being lower in GM-CSF−/− ZIP macrophages than in the WT cells. In addition, GM-CSF ̶IRF4 signaling upregulated MHC class II expression in ZIP macrophages and bone marrow–derived macrophages. Although Ccl17 mRNA expression was reduced in ZIP macrophages in the absence of either GM-CSF or IRF4, thus supporting the presence of the new pathway in inflammatory macrophages, CCL17 did not modulate the inflammatory response, both in terms of number of myeloid cells or the macrophage phenotype. Thus, during an inflammatory response, both macrophage numbers and their phenotype can depend on GM-CSF– and IRF4-dependent signaling independently of CCL17.
Changing Trends in Adolescent Alcohol Use among Czech School-Aged Children from 1994 to 2014
Authors: Kážmér Ladislav , Csémy Ladislav 
Published: April 2019

Background For an efficient planning of public health policy, the regular monitoring over health-related behaviors among vulnerable population groups is necessary. The aim of this study is to examine the temporal trends in alcohol use among the Czech adolescent population. Design and methods Data from the Health Behaviour in Schoolaged Children (HBSC) project conducted in Czechia from 1994 to 2014 were used. Adolescent alcohol use was assessed via two indicators: i) weekly alcohol use (beer, wine, and/or spirit), ii) repeated lifetime drunkenness (having been drunk on two or more occasions in life). Trends in alcohol use were modelled separately for boys and girls. Binary logistic regression was conducted with survey period as an independent predictor of the alcohol indicator. Results There were significant changes in adolescent alcohol use since 1994. Between 1994 and 2010, there was a gradual upward in the prevalence. However, in the recent period of 2014, an unprecedented drop in alcohol use was recorded. Conclusions Despite the significant drop in the prevalence of alcohol use among the Czech youth in recent years, alcohol drinking in adolescence remains an important challenge for the national health policy. Further research will show whether these changes in adolescent health-related behavior are of a temporary or a permanent nature.
Women’s prospects for career advancement: Narratives of women in core mining positions in a South African mining organisation
Authors: Moalusi Kgope P. , Jones Candice M. 
Published: April 2019

Orientation: Even though there has been a phenomenal increase in the number of women employed in the mining industry, the figures hide many gender inequalities as the gendered impediments to career advancement persist despite South Africa’s remarkable equity policy regime. However, it is unclear, from the perspective of the women themselves, how their career advancement is encumbered.Research purpose: This study reflects on the prospects for career advancement by exploring the work and organisational experiences of women in core mining positions in an open-cast mining organisation in South Africa.Motivation for the study: To reflect on the prospects for career advancement of women in core mining positions.Research approach, design and method: Eight professional women, selected through a purposive sampling procedure, participated in in-depth unstructured interviews. Data were analysed using Creswell’s simplified version of the Stevick–Colaizzi–Keen method, guided by the lens of gendered organisations.Main findings: Three themes emerged: (1) male domination that has marginalised women and compelled them to emulate masculinity has legitimised existing gender barriers, (2) the long, awkward and unpredictable hours of work have deepened women’s time constraints because they have to combine the home or family caretaker role with work, and (3) the essence of being a woman in a mining organisation.Practical/managerial implications: The study may present South African managers with a better understanding of how work and organisational features, policies, daily practices and discourses impede career advancement of women in core mining positions. Organisations should train managers to create conditions that minimise barriers and maximise performance and advancement, and align retention strategies.Contribution/value-add: This study builds on existing knowledge about career advancement of women by providing new and valuable information specific to women in core mining positions in an open-cast mining organisation in South Africa, seen through the lens of gendered organisational theory. The findings highlight the need for organisational theory research that is responsive to the subtle issues and gendered assumptions that sustain encumbrances to women’s career trajectories.
Dynamics of wormhole formation in fractured limestones
Authors: Dreybrodt Wolfgang , Gabrovšek Franci 
Published: April 2019

Abstract. Reactive transport in porous or fractured media often results in an evolution
of highly conductive flow channels, often referred to as “wormholes”. The
most spectacular wormholes are caves in fractured limestone terrains. Here, a
model of their early evolution is presented. The modeling domain is a
two-dimensional square net consisting of one-dimensional fractures
intersecting each other in a rectangular grid. Fractures have given width b
and length l, and to each fracture a constant aperture width, a
(homogeneous net), or an aperture width taken from a lognormal statistical
distribution (heterogeneous net) is assigned. The boundary conditions are
constant head h at the input driving the water downstream to the output at
h=0. Linear dissolution kinetics, controlled by surface kinetics and
diffusion, are active. First we discuss the simple case of a homogeneous net.
Two steps in its evolution are observed. In the first, all fractures are
widened evenly and a homogeneous even dissolution front progresses slowly
into the aquifer. The second step is triggered by an instability when, due to
small perturbations, some of the foremost fractures gain length compared to
the neighboring ones. Then, these fractures discharge flow using the parallel
resistances of the net. This way they attract more fresh aggressive water and
their propagation is enhanced. Several wormholes (caves) are penetrating into
the aquifer but only one reaches the output, whereas the others stop growing
due to the redistribution of hydraulic heads caused by the leading wormhole.
The mechanisms governing the evolution of a single wormhole are explored by
increasing the aperture width of one selected input fracture by Δa≪a. In this case, only one single wormhole is created and inspection of the
flow rates along it reveal the mechanism of flow enhancement in detail. If
one uses a heterogeneous net, the first step of evolution is suppressed
because of the large perturbations, and wormholes start to grow immediately.
We have also modeled the case of several competing wormholes in a homogeneous
net by inserting appropriate seeds. We find that there is a critical distance
between the wormholes. Within this distance only one wormhole survives,
whereas there is no interaction between them when they are separated by more
than the critical distance. We also answer the following question: why do
wormholes in a two-dimensional model exhibit breakthrough times at least
1 order of magnitude smaller than a one-dimensional model representing the
aquifer by one single plane-parallel fracture of the same dimensions?
Finally, we present several scenarios with non-homogeneous distribution of
initial aperture widths. In these, a uniform dissolution front does not
develop and wormholes start to grow immediately, which is more likely
expected in nature.
Critical librarianship in health sciences libraries: an introduction
Authors: Barr-Walker Jill , Sharifi Claire 
Published: April 2019

The Medical Library Association recently announced its commitment to diversity and inclusion. While this is a positive start, critical librarianship takes the crucial concepts of diversity and inclusion one step further by advocating for social justice action and the dismantling of oppressive institutional structures, including white supremacy, patriarchy, and capitalism. Critical librarianship takes many forms but, at its root, is focused on interrogating and disrupting inequitable systems, including changing racist cataloging rules, creating student-driven information literacy instruction, supporting inclusive and ethical publishing models, and rejecting the notion of libraries as neutral spaces. This article presents examples of the application of critical practice in libraries as well as ideas for applying critical librarianship to the health sciences. This article has been approved for the Medical Library Association’s Independent Reading Program.
Rhetorizing Philosophy: Toward a “Double Reading” of Philosophical Texts
Authors: Posselt Gerald 
Published: April 2019

ABSTRACTPhilosophy consists primarily in or of texts. The implications of this very basic fact for the subject—both as a writer and as a reader—and philosophy's conception of itself as a privileged form of argumentation and for establishing the truth have, however, been largely neglected. In order to address these issues, the article reconsiders Foucault's “double reading” of Descartes's Meditations as “demonstration” and “exercise” that both affects and transforms the meditating subject. I argue that such a double reading is not only proper to the Meditations but constitutive of all philosophical texts. This leads to a revised notion of truth that derives its argumentative consistency precisely from the entanglement of demonstration and exercise.
Assessment of Spatial Ambient Concentration of NH3 and its Health Impact for Mumbai City
Authors: Kumar Awkash , Patil Rashmi S. , Dikshit Anil Kumar , Kumar Rakesh 
Published: April 2019

Abstract
Generally, ambient Ammonia (NH3) concentration level is always under prescribed limit of government regulatory authorities but the concentration level tends to be higher in surrounding regions of a chemical fertilizer industry. There are many chemical fertilizer industries across the world and 9 public and 18 private fertilizers industries in India. Mostly, air quality monitoring is carried out for many gaseous pollutants and dust such as SO2, NO2, SPM, PM10 and PM2.5 but NH3 is monitored at only few selected locations. Maravali region of Mumbai city has a public sector fertilizer company and this region has maximum concentration of NH3 in Mumbai city. In this study, the spatial average concentration of NH3 was estimated for Mumbai city including and excluding the air quality monitoring site of Maravali, where fertilizer industry is present. The spatial average concentration of Mumbai city is 85 µg/m3 and 56 µg/m3 including and excluding Maravali respectively. The maximum concentration of NH3 is at Maravali and annual average concentration here is 342 µg/m3. This is 6.1 times more of spatial average concentration of Mumbai excluding Maravali. The same was visualized and represented in spatial concentration mapping using Inverse Distance Weighting (IDW) interpolation technique of ArcGIS tool. Also, health impact assessment was carried out for Mumbai city due to the concentration level of NH3. Local Concentration–Response (C-R) coefficient for Mumbai was used to assess health impact for ammonia. 3.4 and 6.8 Million people were exposed by phlegm and other chest illness respectively in Mumbai city. The economic cost of the health was also estimated for the phlegm due to ammonia which was 57 Million USD(3.9 Billion INR) for the year 2012 for Mumbai city.
NOx-VOC-O3 Sensitivity in Urban Environments of Sri Lanka
Authors: Perera G. B. S. , Manthilake M. M. I. D. , Sugathapala A. G. T. , Huy L. N. , Lee S. C. 
Published: April 2019

Abstract
Physical phenomenon of the relation among the ground level O3, NOx and VOC governed by complex nonlinear photochemistry in urban environments is explained in detail using the ambient pollutant concentration data of eleven cities in Sri Lanka. The time-series analysis was conducted using the 24-hour average ambient concentrations of PM10, NO2, CO, O3 and SO2 air pollutants obtained from fixed air pollution monitoring station located in Colombo since 2008. Further analysis was carried out from the mobile air pollution monitoring station for eleven cities. The hourly averaged ambient real time air quality data i.e. VOC, NO2, NO, O3 pollutants and the corresponding meteorological parameters were analyzed and presented in weekly results for the base year 2013, 2014 and 2015. It was identified that there exist two regimes of NOx-VOC-O3 sensitivity among these cities. Colombo, Kurunegala, Jaffna, Matara, Badulla, Pollonnaruwa, and Gampaha are the NOx-sensitive regime. While Rathnapura, Anuradhapura, Kandy and Nuwaraelliya are the VOC-sensitive regime. In the NOx-sensitive regime (with relatively low NOx and high VOC), O3 increases with the increasing NOx and slightly changes in response to the increasing VOC levels. In the NOx-saturated or VOC-sensitive regime, O3 decreases with increasing NOx level and increases with increasing VOC levels. In the immediate vicinity of very large emissions of NO, O3 concentrations are depressed through the process of NOx titration. Mathematical relationships were developed to calculate the steady state ozone concentration (O3ss) that gives the values for both NOx-sensitive regime and the VOC-sensitive regime. Establishment of these relationships are essential for Sri Lanka to develop the appropriate interventions for controlling O3 pollution in each city.
VALIDITÉ ET CRÉDIBILITÉ DANS LE CONTEXTE DE L’EXPERTISE EN NEUROPSYCHOLOGIE CLINIQUE
Authors: Kennepohl Stephan 
Published: April 2019

Au cours des dernières décennies, une multitude de tests et d’indices ont été développés pour tenter de détecter la non-validité des résultats neuropsychologiques. Cependant, la prolifération et la popularité de ces mesures ont contribué à la perception qu’il est dorénavant possible de les utiliser pour identifier la simulation des troubles cognitifs (malingering). Dans cet article, un cadre conceptuel est présenté pour tenter de favoriser une meilleure compréhension des notions sous-jacentes et permettre une meilleure interprétation de la non-validité en expertise. Selon la présente conceptualisation, il existe deux étapes distinctes : la première consiste à discerner la non-validité des données à l’aide de méthodes psychométriques, notamment les tests de validité de performance (TVP). La deuxième requiert une décision quant à la crédibilité du tableau clinique, incluant un jugement quant à la cohérence de l’ensemble des informations cliniques. C’est seulement dans le contexte de certaines incohérences indéniables qu’il serait possible d’avancer une opinion évoquant l’amplification des problèmes cognitifs.
Le Droit et ses médiations
Authors: Miaz Jonathan 
Published: April 2019

Les travaux qui portent sur la mise en oeuvre des politiques publiques et, en particulier, sur la sreet-level bureaucracy appréhendent généralement la question du pouvoir discrétionnaire à un niveau individuel à partir de la liberté d’action dont disposeraient les agents de terrain. Sur la base d’une enquête ethnographique au sein de l’administration responsable du traitement des demandes d’asile en Suisse, cet article analyse la question sous un autre angle : à partir des médiations sociales, institutionnelles et juridiques à travers lesquelles le droit oriente les comportements des agents. L’analyse des médiations du droit révèle surtout l’importance d’un pouvoir normatif collectif de l’administration, qui réside dans l’élaboration de « normes secondaires d’application » par les agents. Cet article montre aussi qu’il existe, au sein de l’institution, tout un travail à la fois juridique et social qui encadre, oriente et contraint les pratiques des agents.
CREATING A SPACE FOR INNOVATIVE TEACHING, LEARNING AND SERVICE DELIVERY
Authors: Karabanow Jeff , Hall Cyndi , Davies Harriet , Murphy Andrea , Martin-Calero Piedad , Oulton Sarah , Titus Michelle 
Published: April 2019

The School of Social Work Community Clinic opened its doors in June, 2014 in a donated space in a local parish hall. With very few resources initially the clinic now has its own rented space, serves a caseload of over 200 marginalized community members and has provided field placement experiences for over 75 BSW/MSW, pharmacy, psychology, nutrition, nursing, and occupational therapy students. In this article, we will highlight the steps we took to create and develop the Clinic with a social justice/anti-oppressive foundation, and the practice-teaching approaches we use with our students. We will also describe how we are integrating an interprofessional and community-university partnership culture in our day-to-day work with marginalized populations. This process will be described and discussed in relation to both interprofessional health education and the provision of relevant and meaningful services to clients. The community development techniques we used to develop our clinic and how we have been able to grow and expand will be highlighted. The partners we have established in government, the university, and the community that have contributed to a more sustainable future are also described.
Le calcul des aliments du parent de fait : de l’approche synchronique à l’approche étapiste
Authors: Lessard Michaël 
Published: April 2019

Le présent article porte sur le calcul des aliments versés par les parents de fait en droit québécois. Il se divise en quatre parties. Dans la première, l’auteur explique dans quelle mesure les parents de fait québécois peuvent être tenus de fournir des aliments en vertu de la doctrine in loco parentis qui s’applique aux couples mariés. Dans la deuxième partie, il détaille la méthode prévue en droit privé fédéral pour calculer les aliments payables par une personne tenant lieu de parent. Dans la troisième, l’auteur émet l’hypothèse selon laquelle le droit civil québécois préconise une approche synchronique de calcul des aliments payables par les parents de fait et les parents civils non gardiens. Enfin, dans la quatrième partie, il recommande l’adoption d’une approche étapiste pour le calcul des pensions alimentaires.
Selon l’approche étapiste, l’obligation alimentaire du parent de fait est subsidiaire à celle du parent civil. La pension alimentaire de ce dernier est d’abord déterminée sans prendre en considération le parent de fait. Celle du parent de fait est ensuite évaluée suivant les règles habituelles mais, pour obtenir sa valeur réelle, on lui soustrait le montant versé par le parent civil : la pension du parent de fait devient complémentaire de la pension du parent civil. Le parent civil est donc soumis à une obligation primaire et le parent de fait, à une obligation secondaire. Cette approche comporte quatre avantages : 1) elle favorise la stabilité de la situation financière de l’enfant ; 2) elle témoigne du rôle exercé par le parent de fait au cours de la vie commune ; 3) elle permet d’éviter des injustices envers le parent civil gardien ; et 4) elle favorise la préservation de l’institution de la filiation.
“Dance Me Through the Panic Till I’m Gathered Safely In”
Authors: Buchanan Sandra 
Published: April 2019

When Leonard Cohen died in November 2016, many people the world over felt very sad and indeed bereft, at the loss of such a great artist, poet and songwriter. It felt, in Auden’s (1958) words on Freud’s death, another example of:
For every day they dieamong us, those who were doing us some good, who knew it was never enough buthoped to improve a little by living. (p. 68)
The title of this paper comes from Leonard’s 1984 song “Dance Me to the End of Love”, and has often seemed a powerful description of what a mother provides for her baby and what we as therapists provide to our clients. We try to help them “dance through the panic” and ultimately to feel safely gathered in — firstly with us, within the therapeutic relationship, and in due course within themselves. We provide a “promise of home”, or at least some hope for our clients that they might be able to find that individual sense of self within themselves and connection to others, which feels like “home”.
Whakarāpopotonga
I te matenga o Leonard Cohen i te Whiringa-a-rangi 2016, pōuri kau ana te tini te mano huri noa i te ao mōteatea kau ana i te ngarohanga atu o te tohunga tito waiata, toikupu mahi toi nei. E ai ki tā Ōtene kī (1958) i te matenga o Whoritu:
Mō ia rā taki hingarō ngai tātau, rātau e whai hua nei mō tātau, mōhio tonu kore rawa i rahi engaritōminahia mā te kaiao e whakawhanake. (w. 68)
I ahu mai te pane o tēnei pepa mai i te waita a Renana o te tau 1984 “Kanikanihia au ki te Mutunga o te Aroha”, ā, tērā ia e whakaarohia ana he whakaahuatanga mārohirohi o te o te āhua whakarato a te whaea i tana pēpē me tā tātau ngā kaiwhakaora hinengaro hoki ki ā tātau kiritaki. Ko tā tātau he nana ki te āwhina i a rātau, “pīkarikari i te maurirere” ā, taioreore kia tau te mauritau ki a tātau, i tō tātau whanaungatanga haumanutau tae atu ki te wā e tau ai tō rātau ake mauri. Ko tā tātau he whakarato “oati mauri tau”, he maramara wawata rānei e kitea ai e ā tātau kiritaki he kiritau, he whanaungatanga ki ētahi atu pēnei tonu i te “kāinga”.
Accumulation by Dispossession
Authors: Fenton Robert P. 
Published: April 2019

Abstract
David Harvey, one of the most influential urban theorists of the last 40 years, attempted to overcome a perceived gap in Marxist theory centered on noncapitalistic forms of accumulation necessary for capitalism to function. Accumulation by dispossession is his attempt to bridge that gap. By exploring the intellectual roots of the concept, its own historical context, as well as some of the internal limitations of the concept, this entry will situate accumulation by dispossession within the sometimes divergent interests of Marxist analysis and urban and regional studies. It is the tension between the general‐historical contours of accumulation by dispossession and its more particular application in urban studies that can push research in new directions.
Alun‐Alun
Authors: Mahatmanto  , Prawoto Eko 
Published: April 2019

AbstractAs a concept of space,alun‐alunhas its roots in the open field located in front of the house of the village chief, a phenomenon that is found across the Indonesian archipelago. Historically, the termalun‐alunwas related to urban planning in inland Java, becoming the symbol of an ocean wave in which the city's population came together. As it developed in later periods the termsalun‐alun utaraandalun‐alun selatanbegan to be used by the inland government administrations, and the concept underwent symbolic elaboration. The idea of the core (axis mundi) was being embodied in urban planning through the open space ofalun‐alunand the assembled buildings surrounding it. Modern urban planning in Indonesia follows the development of modern cities but continues to strengthen the components of the city center based on the concept ofcatur tunggal, which is applied to the spatial organization of all districts throughout Indonesia.