bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulating individually targeted transcranial electric stimulation for experimental application
Authors: Radecke Jan-Ole , Khan Asad , Engel Andreas K. , Wolters Carsten H. , Schneider Till R. 
Published: August 2019

AbstractTranscranial electric stimulation (tES) induces electric fields that are subject to a complex interaction with individual anatomical properties, such as the low-conducting human skull, the distribution of cerebrospinal fluid or the sulcal depth, as well as stimulation target location and orientation. This complex interaction might contribute to the heterogenous results that are commonly observed in applications of tES in humans. Targeted tES, on the other hand, might be able to account for some of these individual factors. In the present study, we used the finite-element method (FEM) and head models of twenty-one participants to evaluate the effect of individually targeted tES on simulated intracranial current densities. Head models were based on an automated segmentation algorithm to facilitate processing in experimental sample sizes. We compared a standard stimulation montage to two individually optimized tES montages using an Alternating Direction Method of Multipliers (ADMM) and a Constrained Maximum Intensity (CMI) approach. A right parietal target was defined with three different orientations. Individual current densities showed varying intensity and spatial extent near the lower limit at which physiological efficacy of electric fields can be assumed. Both individually optimized targeting algorithms were able to control the electric field properties, with respect to intensities and/or spatial extent of the electric fields. Still, across head models, intensity in the stimulation target was constrained by individual anatomical properties. Thus, our results underline the importance of targeted tES in enhancing the effectiveness of future tES applications and in elucidating the underlying mechanisms.
Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma
Authors: Ordoñez Raquel , Kulis Marta , Russiñol Nuria , Chapaprieta Vicente , Beekman Renée , Meydan Cem , Duran-Ferrer Martí , Verdaguer-Dot Núria , Clot Guillem , Vilarrasa-Blasi Roser , Garate Leire , Miranda Estíbaliz , Carrasco Arantxa , Ezponda Teresa , Vilas-Zornoza Amaia , Lara-Astiaso David , Dupéré-Richer Daphné , Martens Joost H.A. , Torrents David , El-Omri Halima , Taha Ruba Y , Calasanz Maria J. , Paiva Bruno , Miguel Jesus San , Flicek Paul , Gut Ivo , Melnick Ari , Mitsiades Constantine S. , Licht Jonathan D. , Campo Elias , Stunnenberg Hendrik G. , Agirre Xabier , Prosper Felipe , Martin-Subero Jose I. 
Published: August 2019

ABSTRACTMultiple myeloma (MM) is a plasma cell neoplasm associated with a broad variety of genetic lesions. In spite of this genetic heterogeneity, MMs share a characteristic malignant phenotype whose underlying molecular basis remains poorly characterized. In the present study, we examined plasma cells from MM using a multi-epigenomics approach and demonstrated that when compared to normal B cells, malignant plasma cells showed an extensive activation of regulatory elements, in part affecting co-regulated adjacent genes. Among target genes upregulated by this process, we found members of the NOTCH, NFkB, mTOR1 signaling and p53 signaling pathways. Other activated genes included sets involved in osteoblast differentiation and response to oxidative stress, all of which have been shown to be associated with the MM phenotype and clinical behavior. We functionally characterized MM specific active distant enhancers controlling the expression of thioredoxin (TXN), a major regulator of cellular redox status, and in addition identifiedPRDM5as a novel essential gene for MM. Collectively our data indicates that aberrant chromatin activation is a unifying feature underlying the malignant plasma cell phenotype.
Fabrication of Mn–Co–Ni-coated layer on AISI 304 stainless steel for protection of Cr evaporation by electroplating process
Authors: Taweesup Kattareeya , Khotsombat Sirirat , Chubanjong Kongkwan , Wutthiseelanon Siraphatsorn 
Published: August 2019

Purpose
This study aims to improve the oxidation resistance of SS304 stainless steel by fabrication of Mn–Co–Ni-coated layer. Mn–Co–Ni coating with the thickness ranging from 1.76 to 8.50 micron were prepared by electroplating process on SS304 stainless steel, focusing on the plating time which play significant roles on the performance of the film thickness and crystallize size.

Design/methodology/approach
Mn–Co–Ni coating layer was applied on AISI 304 stainless steel using electroplating process with solution consisted of cobalt sulfate (CoSO4), manganese sulfate (MnSO4) and nickel sulfate (NiSO4). Variation of Mn–Co–Ni coating, the morphology of the film and oxidation kinetics were investigated by using scanning electron microscopy and x-ray diffraction analysis. Furthermore, the sample with coating layer was tested by oxidation and Cr evaporation test.

Findings
From the formation parameter due to plating time for the conversion coating, it was found that plating time plays significant roles in the performance of the coating thickness and crystallize size. The crystallize size has an inverse relation to the full width at half maximum of diffraction peak. Film thickness higher than 6.07 micron causes a decrease in oxidation resistance and an increase of Cr evaporation from SS304 stainless steel. In this study, the Mn–Co–Ni coating with a thickness lower than 3.77 micron showed coating protection of oxidation better than SS304 substrate.

Originality/value
The effect of coating thickness was investigated to understand the properties of the coating. Furthermore, oxidation and Cr evaporation test were applied to evaluate the oxidation resistance of the coating layer.
Building a business model for a new form of hospitality: the albergo diffuso
Authors: Fissi Silvia , Romolini Alberto , Gori Elena 
Published: August 2019

Purpose
In recent years, tourists have become more interested in discovery the authenticity of a destination. The albergo diffuso (AD) is a response to this new requirement of tourist experience. The AD indeed is based on an accommodation solution with rooms distributed in various buildings across a village. The purpose of this study is to analyze the AD business model supporting the development of this emerging business opportunity in the accommodation industry.

Design/methodology/approach
The research is conducted with a multiple case study approach, collecting data from different sources such as semi-structured interviews and archival research. The cases are all located in Italy where the AD was applied for the first time.

Findings
The AD business model is based on business idea, value creation and innovation. The business idea is based on the aim to contribute to the renaissance of a village with an emotional link between the entrepreneur and the village. Regarding the value creation, the AD is a form of accommodation that offers more than a hotel experience. The tourist can live like a resident and experiencing local traditions and culture. The innovation is indeed related to the services that are totally different from a traditional hotel.

Originality/value
Considering the previous studies, this research tries to fill the gap concerning the necessity to define the characteristics of the AD business model and to understand the key elements at the base of this hospitality approach.
Barcelona’s peer-to-peer tourist accommodation market in turbulent times
Authors: Benítez-Aurioles Beatriz 
Published: August 2019

Purpose
The purpose of this paper is to assess the impact of sociopolitical instability on the peer-to-peer market for tourist accommodation.

Design/methodology/approach
The author studies for the case of Barcelona the impacts of the events occurring in the past months of 2017, which consisted of a terrorist attack and the calling for a referendum on the independence of Catalonia, by fitting a fixed effects regression model to a data panel of Airbnb listings, using New York and Paris as a control group.

Findings
The results show that, after controlling for individual and time effects, listing reviews and revenues fall in the last quarter of 2017 and do not recover until the second quarter of the next year, in spite of a notable effort to decrease prices in the same period. They also indicate that peer-to-peer hosts react fast to demand shocks and as those from traditional markets.

Originality/value
This is the first study to evaluate the impact of terrorism or political uncertainty in the peer-to-peer market and the first to evaluate their combined effect in any market.
Learning, friendship and social contexts
Authors: Mamas Christoforos , Daly Alan J. , Struyve Charlotte , Kaimi Irene , Michail George 
Published: August 2019

Purpose
The purpose of this paper is to introduce a social network analysis (SNA) toolkit aiming to enable leaders, educators and researchers work together to deepen their understanding of classroom social network dynamics. In doing so, the authors provide both theoretical and practical steps in building a bridge between theory and practice and a step-by-step introduction to designing and implementing SNA to understand socially responsive classrooms. To make the case, the authors present data that were collected through an SNA survey completed by eighth graders in two highly diverse classrooms in Southern California.

Design/methodology/approach
Driven by an SNA perspective, the authors highlight the potential value of examining social interdependencies and interconnectedness among students in a classroom network. The SNA toolkit was employed to calculate social network measures and develop network maps for each classroom.

Findings
The toolkit has shown to provide a comprehensive platform in gaining important insights into students’ social relationships, particularly those who are underserved and at higher risk of exclusion. The findings have shown that some of the students in the two classrooms were more likely to remain on the periphery of their social networks, particularly those who are traditionally more likely to be marginalized including students with disabilities as well as racially and linguistically diverse students.

Originality/value
The toolkit in the hands of leaders and teachers may provide a powerful tool for personalized professional development and act as a catalyst in bridging the gap between research and practice.
After the crisis: repairing a corporate image
Authors: Sawalha Ihab Hanna 
Published: August 2019

Purpose
The purpose of this paper is to discuss the effectiveness of image-repair strategies adopted by organizations to restore their public image and reputation following crisis situations, the lessons learned from these cases and the significance of contextual factors that are likely to affect image-repair efforts and strategies adopted.

Design/methodology/approach
Three cases have been reviewed in this paper: Weather, Jordan; Nestlé Waters, Jordan; and Victoria College School, Jordan. Information was obtained from published materials, such as YouTube commentaries, local newspapers and online news agents, primarily the Jordan Times, which is considered the number one daily in the country. The discussion of these cases is original and based on academic theory and literature.

Findings
Organizations differ in terms of the ways they respond to corporate crises and the strategies they are likely to adopt to restore/recover their reputation and public image.

Practical implications
Corporate reputation or public image is an asset that is built over time. Organizations within all industries seek to secure positive images in the minds of people. The image of an organization however can be threatened by crises. Trust and public image decline when stakeholders feel they have not been adequately informed in times of crises regarding the different attributes of the situation or how the organization is dealing with the crisis. Organizations have the choice to adopt one image-repair strategy at a time or a combination of strategies according to the requirements of the situation.

Originality/value
Image-repair strategies have been examined in American and European contexts but have, to the author’s knowledge, never been examined in the context of Arab organizations and more specifically in the context of Jordanian organizations. This paper therefore provides a new insight into how to apply these strategies in a unique and new context and will also motivate future research in this regard.
Are teacher-credentialing programs providing enough training in multiculturalism for pre-service teachers?
Authors: Delk Tricia Denise 
Published: August 2019

Purpose
The purpose of this study is to explore how multicultural curriculum and instruction in a teacher-credentialing program prepared pre-service teachers to work with diverse students.

Design/methodology/approach
The research method used was a qualitative approach. The research design was a descriptive single embedded case study to interview pre-service teachers who were in their second semester in a teacher-credentialing program at a university on the west coast and pre-service teachers who were in their final semester in the same teacher-credentialing program. Pre-service teachers discussed their disappointment in the program for their lack of training in how to work with culturally diverse students.

Findings
The findings from the study will add to the body of knowledge specific to teacher-credentialing programs, curriculum developers and universal design for learning on K-12 education.

Research limitations/implications
As schools become more diverse, an important role of teacher-credentialing courses is to train future teachers with the knowledge to assist culturally diverse students. If teachers were multicultural teachers, they would be better prepared to instruct culturally diverse students and could acknowledge sociocultural resources and information that students bring to the classroom.

Originality/value
The study is essential because training teachers to instruct culturally diverse students is critical as student demographics become more diverse.
Experimental studies and theoretical models for concrete columns confined with FRP composites: a review
Authors: Gora Abdurra’uf M. , Jaganathan Jayaprakash , Anwar M.P. , Leung H.Y. 
Published: August 2019

Purpose
Advanced fibre-reinforced polymer (FRP) composites have been increasingly used over the past two decades for strengthening, upgrading and restoring degraded civil engineering infrastructure. Substantial experimental investigations have been conducted in recent years to understand the compressive behaviour of FRP-confined concrete columns. A considerable number of confinement models to predict the compressive behaviour of FRP-strengthened concrete columns have been developed from the results of these experimental investigations. The purpose of this paper is to present a comprehensive review of experimental investigations and theoretical models of circular and non-circular concrete columns confined with FRP reinforcement.

Design/methodology/approach
The paper reviews previous experimental test results on circular and non-circular concrete columns confined with FRP reinforcement under concentric and eccentric loading conditions and highlights the behaviour and mechanics of FRP confinement in these columns. The paper also reviews existing confinement models for concrete columns confined with FRP composites in both circular and non-circular sections.

Findings
This paper demonstrates that the performance and effectiveness of FRP confinement in concrete columns have been extensively investigated and proven effective in enhancing the structural performance and ductility of strengthened columns. The strength and ductility enhancement depend on the number of FRP layers, concrete compressive strength, corner radius for non-circular columns and intensity of load eccentricity for eccentrically loaded columns. The impact of existing theoretical models and directions for future research are also presented.

Originality/value
Potential researchers will gain insight into existing experimental and theoretical studies and future research directions.
Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell‐induced bone pain
Authors: Shenoy Priyank A. , Kuo Andy , Leparc German , Hildebrandt Tobias , Rust Werner , Nicholson Janet R. , Corradini Laura , Vetter Irina , Smith Maree T. 
Published: August 2019

AbstractIn patients with breast cancer, metastases of cancer cells to the axial skeleton may cause excruciating pain, particularly in the advanced stages. The current drug treatments available to alleviate this debilitating pain condition often lack efficacy and/or produce undesirable side effects. Preclinical animal models of cancer‐induced bone pain are key to studying the mechanisms that cause this pain and for the success of drug discovery programs. In a previous study conducted in our laboratory, we validated and characterised the rat model of Walker 256 cell‐induced bone pain, which displayed several key resemblances to the human pain condition. However, gene level changes that occur in the pathophysiology of cancer‐induced bone pain in this preclinical model are unknown. Hence, in this study, we performed the transcriptomic characterisation of the Walker 256 cell line cultured in vitro to predict the molecular genetic profile of this cell line. We also performed transcriptomic characterisation of the Walker 256 cell‐induced bone pain model in rats using the lumbar spinal cord and lumbar dorsal root ganglia tissues. Here we show that the Walker 256 cell line resembles the basal‐B molecular subtype of human breast cancer cell lines. We also identify several genes that may underpin the progression of pain hypersensitivities in this condition, however, this needs further confirmatory studies. These transcriptomic insights have the potential to direct future studies aimed at identifying various mechanisms underpinning pain hypersensitivities in this model that may also assist in discovery of novel pain therapeutics for breast cancer‐induced bone pain.
Combined Approach for Determining Diuron in Sugarcane and Soil: Ultrasound‐Assisted Extraction, Carbon Nanotube‐Mediated Purification, and Gas Chromatography–Electron Capture Detection
Authors: Chen Bi , Wang Xiaoming 
Published: August 2019

AbstractDiuron is a urea herbicide that is frequently detected in surface water, groundwater, and marine waters. However, there are few methods or guidelines reported on ensuring the quality of sugarcane and soil. In this study, a method was developed for detecting diuron to ensure the quality and safety of food and sugar. Mass spectrometry was used to identify 3,4‐dichloroaniline as a marker for the thermal decomposition of diuron, and thus, as a representative component for quantitative diuron analysis. This approach can be used to rapidly detect trace amounts of diuron. In addition, ultrasound‐assisted extraction (UAE) and carbon nanotube column purification were used in conjunction with gas chromatography–electron capture detection to detect diuron. The method was then evaluated for its accuracy, detection limit, and viability. The effects of extraction solvent, ultrasound time, and ultrasound power on the extraction efficiency of the analyte from sugarcane and soil were also investigated. The efficiency and optimum conditions of UAE were examined through single‐factor experiments and Box–Behnken design (BBD). The optimal extraction conditions were identified as follows: acetonitrile as the extraction solvent, extraction temperature of 27 °C, extraction time of 3.4 min, and ultrasound power of 70 W. Under these conditions, high linearity was achieved for diuron concentrations of 0.01 to 5.0 mg/L, and the purification correlation coefficient was consistently greater than 0.998. Hence, gas chromatography, combined with UAE and BBD, offers superior efficiency extraction, which is sufficiently accurate and precise for pesticide residue analysis.Practical ApplicationWe developed an accurate and cost‐effective method for detecting diuron (a commonly used herbicide) in soil and sugar samples. We performed experiments to determine the optimum detection conditions for our method. This method can be used for online monitoring of sugar manufacturing processes to ensure food safety and quality.
Characterization of Volatile Compounds by SPME‐GC‐MS During the Ripening of Kedong Sufu, a Typical Chinese Traditional Bacteria‐Fermented Soybean Product
Authors: Fan Xuejing , Liu Gefei , Qiao Yali , Zhang Yanjiao , Leng Cong , Chen Hongyu , Sun Jiahui , Feng Zhen 
Published: August 2019

AbstractThe purpose of the present study was to evaluate the volatile profile of Kedong sufu, which is a typical bacteria‐fermented soybean product in China, using solid phase microextraction coupled to gas chromatography and mass spectrometry and to reveal the evolution and diversity of flavor substances for this specialty. A total of 75 compounds were identified, including 35 esters, 4 alcohols, 4 phenols, 4 aldehydes, 7 acids, 10 ketones, and 11 other compounds from sufu samples during ripening. Some volatile compounds increased with ripening time, especially hexadecenoic acid ethyl ester, methoxy acetic acid pentyl ester, benzene propanoic acid ethyl ester, ethyl 9‐hexadecenoate, ethyl oleate, ethanol, 3‐methyl‐1‐butanol, 5‐methoxy‐1‐pentanol, and eugenol; these compounds enriched the flavors and provided the typical savory taste of Kedong sufu.Practical ApplicationThis research elucidated the formation of flavor substances in sufu. For traditional fermented foods, this study provides a scientific basis for promoting the generation of typical flavor substances and for the precise determination of maturity time.
EndoCuff‐assisted colonoscopy could improve adenoma detection rate: A meta‐analysis of randomized controlled trials
Authors: Jian Hai Xu , Feng Bing Cheng , Zhang Yan , Qu Jun Yan , Li Yue Yue , Zuo Xiu Li 
Published: August 2019

ObjectiveThis meta‐analysis aimed to evaluate whether EndoCuff‐assisted colonoscopy (EAC) could improve adenoma detection rate (ADR) compared with standard colonoscopy (SC).MethodsPubMed, EMBASE, Scopus, Cochrane Library, and Google Scholar databases were searched for articles published up to March 2019. All pure randomized controlled trials comparing ADR between EAC and SC groups were included. Dichotomous data were pooled to obtain the odds ratio with a 95% confidence interval (CI), whereas continuous data were pooled using a mean difference with 95% CI. Review Manager Version 5.3 was used for data analysis.ResultsThirteen randomized controlled trials consisting of 9038 patients (EAC: 4574; SC: 4464) were included. The EAC group showed significant superiority over the SC group in ADR (odds ratio 1.37, 95% CI 1.15–1.62). However, there were no differences between the EAC and SC groups in adverse events, cecal intubation rate, and cecal intubation time.ConclusionsEAC could significantly improve ADR without increasing adverse events, especially for operators with low ADRs. In addition, no significant difference was observed in cecal intubation time and cecal intubation rate between EAC and SC.