bluuebunny/crossref_metadata_2025_split huggingface dataset:
INTERFACES DA (NÃO) ADESÃO AO TRATAMENTO DO DIABETES MELLITUS TIPO II
Authors: Santos Wallison Pereira dos , Silva Myllene Miguel da , Freitas Fernanda Beatriz Dantas de , Souza Fernanda Teixeira de 
Published: August 2019

A não adesão ao tratamento medicamentoso é a principal causa de insuficiência da terapêutica, ocasionando ainda intoxicações pelo uso irracional de medicamentos e agravos no processo patológico. Identificar os fatores contribuintes para a não adesão ao tratamento medicamentoso, tal como suas possíveis complicações. Estudo descritivo do tipo revisão integrativa da literatura, nas bases de dados LILACS, BDENF, MEDLINE e SCIELO. Os descritores foram devidamente consultados no Descritores em Ciências da Saúde , selecionou-se: “Atendimento em Enfermagem”, “Diabetes Mellitus tipo II” e “ Tratamento medicamentoso”, a fim de permitir o cruzamento simultâneo utilizou-se o operador booleano AND. Foram incluídos estudos que apresentavam relação com a temática central, disponíveis na integra, nos idiomas português, inglês e espanhol, no período de 2010 a 2019. A busca nas bases de dados resultou na coleta de 16 artigos, que preencheram adequadamente os critérios estabelecidos e foram selecionados para inclusão no estudo. A partir da análise das publicações inclusas na revisão foi possível constatar que grande parte dos estudos se referem a preocupação da não adesão ao tratamento medicamentoso do Diabetes Mellitus, sendo assim, emergiu-se 3 categorias temáticas, a saber: C1- Contribuintes para a não adesão ao Tratamento medicamentoso; C2- Complicações advindas da não adesão ao tratamento medicamentoso e C3- A polifarmácia e suas interfaces. Identificou-se que existem fatores sociais, educacionais e comportamentais que contribuem para a adesão ou não ao tratamento, além de apresentar as complicações que a não adesão pode trazer para a vida da pessoa com DM.
Microsurgery in complex trauma of pelvic limb in a pediatric patient: case report
Authors: Banegas-Ruíz Rodrigo , Loyo Soriano Luis E. , Gómez-Mendoza Francisco Fabián , Mendoza-Aceves Rodrigo A. , Hernández Rigoberto Román , Méndez Christian Porras , Valderrama-Treviño Alan I. , Ortega Emilio Pérez , Alba Ismael Vejar , Ulloa Rubén Olivares , Hernández-Arteaga Leonel Dalain , Járez-Duarte Erick Salvador , Mera Baltazar Barrera 
Published: August 2019

Complex trauma is defined as the condition secondary to the exchange of kinetic energy of two or more tissues in one limb. This entity is a surgical emergency that can have many sequelae and can even result in limb loss. An 11-year-old female patient presents complex pelvic limb trauma secondary to contuse injury caused by a helicopter’s rotor blades. Pelvic limb reconstruction was performed with iliac crest bone graft, the fracture was stabilized with an external fixator and the skin defect was covered with an anterolateral microvascular thigh flap (ALT). There was an adequate integration of the bone graft with adequate skin coverage thanks to the ALT thigh flap. The patient presented discreet limb shortening as consequence. Currently, microsurgery is the only medical option that meets the objectives of limb reconstruction. Microsurgical techniques can be used in pediatric and adult patients. The success of any recovery from complex trauma is vigorous surgical cleaning, avoiding sequential and/or multiple washes.
PERAN KEPEMIMPINAN KEPALA MADRASAH DALAM MENGEMBANGKAN BUDAYA MEMBACA AL-QUR’AN DI MADRASAH TSANAWIYAH NEGERI 1 PALEMBANG
Authors: Wati Erna 
Published: August 2019

This background of the effort to improve the learning process of the Qur'an is necessary because the Qur'an is the source of the law and the main rule for Muslims and grace performed MTs N 1 Palembang. The purpose of this research is to know and understand the role of leadership of madrasah head in developing the culture of reading al-Qur'an in MTs Negeri 1 Palembang and the impact of leadership role of madrasah head in developing the culture of reading al-Qur'an in MTs Negeri 1 Palembang. The research results obtained the following results: The role of leadership of madrasah head in developing the culture of reading the Qur'an in MTs Negeri 1 Palembang seen in the ability to coordinate the activities tahfidz al-Qur'an, in terms of problem solving in the program of culture al-Qur 'An, he gave authority to the concerned to solve it. The principal establishes communication with good language especially on issues in which the cultural activities of reading the Qur'an are concerned. The principal has given good motivation to the participants tahfidz the teacher in charge, both in the form of praise, trust and physical form. The impact of the leadership role of madrasah head in developing the culture of reading al-Qur'an in MTs Negeri 1 Palembang make the program of reading al-Qur'an culture focused on the activities of tahfidz al-Qur'an in MTs N 1 Palembang run effectively proven by many students Already memorized 1 juz even have 5 and 7 juz.
Special Issue on the Western Japan Heavy Rain
Authors: Hayashi Haruo 
Published: August 2019

In 2018, Japan not only had an abnormally hot summer, but also experienced successive disasters, including the Northern Osaka Earthquake, the Western Japan Heavy Rain, Typhoon No. 21, the Hokkaido Mid Iburi Earthquake, and Typhoon No. 24. In particular, the record-breaking heavy rains continued in a large area of Western Japan from June 28 to July 4, due to the storm front and Typhoon No. 7. The amount of rainfall totaled over 1,800 mm in the Shikoku Region and 1,200 mm in the Tokai Region. The quantity of rain that fell within 48 and 72 hours in both the Chugoku and Kinki Regions, as well as many other areas, was the highest rainfall ever recorded. A special warning regarding heavy rain was issued in 10 prefectures and every kind of disaster that Japan had experienced recently occurred in various locations. As of August 21, a report from Disaster Management Section, Cabinet Office indicated 221 deaths, 9 missing persons, 68 severely injured persons, 319 slightly injured persons, 3 persons with an unknown level of injury, 6,206 destroyed homes, 9,764 severely-damaged homes, 3,765 partially-destroyed homes, 9,006 homes with flooding above the first-floor level, and 20,086 houses with flooding below the first-floor level.
During this large-scale disaster, which was named the Western Japan Heavy Rain, the Disaster Relief Act was applied to 110 municipalities and JDR decided to issue a special edition to address issues pertinent to this specific disaster event. Paper submissions were requested that not only comprised demonstrative researches on hazard and damage characteristics, methods of evacuation, and features of disaster response, but also included introductions of best practices, which were conducted in various fields and prompted diverse collaboration to develop and establish measures to mediate the effect of the future Nankai Trough Earthquake, as well as problems and solutions to successfully realize diverse collaboration. In response to the call for papers for the special issue, nine researches were submitted and six were accepted following a strict review process. To address the category of hazard characteristics analyses, two papers analyzing the characteristics of the flooding resulting from the Western Japan Heavy Rain and one paper comprising an analysis of landslide disasters were accepted. In the category of disaster response, one paper focusing on the use of SNS and two papers regarding the elderly were accepted. It would be our sincere pleasure if this special issue could contribute to future reductions in damage resulting from natural disasters.
Vibiro vulnificus hemolysin binds to gangliosides.
Authors: KASHIMOTO Takashige , Sugiyama Hiroyuki , Kawamidori Keigo , Yamazaki Kohei , Kado Takehiro , Matsuda Kaho , Mukai Takao , Ueno Shunji 
Published: August 2019

Abstract
Abstract
Background: Vibrio vulnificus hemolysin (VVH) is a pore-forming toxin secreted by Vibrio vulnificus. Cellular cholesterol was believed to be the receptor for VVH, because cholesterol could bind to VVH and preincubation with cholesterol inhibited cytotoxicity. It has been reported that specific glycans such as N-acetyl-D-galactosamine and N-acetyl-D-lactosamine bind to VVH, however, it has not been known whether these glycans could inhibit the cytotoxicity of VVH without oligomer formation. Thus, to date, binding mechanisms of VVH to cellular membrane, including specific receptors have not been elucidated.
Results: We show here that gangliosides are a good candidate cellular receptor for VVH. Binding of VVH was not affected by depletion of cholesterol on ghost membrane. In contrast, ganglioside GM1a, Fucosyl-GM1, GD1a, GT1c, and GD1b bind to VVH directly, and the GD1a inhibited the cytotoxicity of VVH without the formation of oligomers.
Conclusion: This is the first report of a molecule able to inhibit the binding of VVH to target cells without oligomerization of VVH.
A mutant allele of zeta-carotene isomerase (Z-ISO) is associated with the yellow pigmentation of the ‘Pinalate’ sweet orange mutant and reveals insights into its role in fruit carotenogenesis
Authors: Rodrigo Maria Jesus , Lado Joanna , Alos Enriqueta , Alquezar Berta , Dery Orly , Hirschberg Joseph , Zacarias Lorenzo 
Published: August 2019

Abstract
Fruit coloration is one of the main quality parameters of Citrus fruit primarily determined by genetic factors. The fruit of ordinary sweet orange (Citrus sinensis) displays a pleasant orange tint due to the accumulation carotenoids, representing b,b-xanthophylls more than 80% of the total content. Pinalate is a spontaneous bud mutant derived from sweet orange Navelate, characterized by yellow fruits due to elevated proportions of upstream carotenes and reduced b,b-xanthophylls. To identify the molecular basis of Pinalate yellow fruit, a complete characterization of carotenoids profile together with transcriptional changes in carotenoid biosynthetic genes were performed in mutant and parental fruits during development and ripening. Pinalate fruit tissues showed a distinctive carotenoid profile at all ripening stages, accumulating phytoene, phytofluene and unusual proportions of 9,15,9´-tri-cis- and 9,9´-di-cis-z-carotene, while content of downstream carotenoids was significantly decreased. Transcript levels for most of the carotenoid biosynthetic genes showed no alterations in Pinalate; however, the steady-state level mRNA of z-carotene isomerase (Z-ISO), which catalyses the conversion of 9,15,9´-tri-cis- to 9,9´-di-cis-z-carotene, was significantly reduced in Pinalate fruit and leaf tissues. The isolation of the Pinalate Z-ISO genomic sequence identified a new allele with a single nucleotide insertion at the second exon, which generates an alternative splicing site that alters Z-ISO transcripts encoding non-functional enzyme. Moreover, functional assays of citrus Z-ISO in E.coli showed that light is able to enhance a non-enzymatic isomerization of tri-cis to di-cis-z-carotene which is in agreement with the partial rescue of mutant phenotype when Pinalate fruits are highly exposed to light during ripening. The defect in Pinalate Z-ISO gene causes a bottleneck in the carotenoid pathway with an unbalanced content of carotenes upstream to b,b-xanthophylls in fruit tissues. Taken together, our results indicate that a spontaneous single nucleotide insertion in Z-ISO is the molecular basis of the altered pigmentation in Pinalate sweet orange mutant and points this isomerase as an essential activity for carotenogenesis in citrus fruits.
The predicted Meloidogyne javanica effectome is governed by the 9-hydroxide oxylipin of linolenic acid
Authors: Fitoussi Nathalia , Borrego Eli , Kolomiets Michael V , Xue Qing , Bucki Patricia , Sela Noa , Belausov Eduard , Miara Sigal Braun 
Published: August 2019

Abstract
Background: The sedentary root-knot nematode Meloidogyne spp. secretes effectors in a spatial and temporal manner to interfere with and mimic multiple physiological and morphological mechanisms, supporting construction and maintenance of nematodes' feeding sites. For successful parasitism, many effectors act as immunomodulators, aimed to manipulate and suppress immune defense signaling triggered upon nematode invasion.
Results: Comprehensive oxylipin profiling of tomato roots, performed using LC–MS/MS, indicated a sharp fluctuation in oxylipin profile following Root Knot Nematode infection. To identify genes that might respond to the lipidomic defense pathway mediated through oxylipins, RNA-Seq was performed by exposing Meloidogyne javanica second-stage juveniles to tomato protoplasts and the oxylipin 9-HOT, early induced in tomato roots upon nematode infection. A total of 4810 differentially expressed genes were identified. To target putative effectors, we explored differentially expressed genes carrying a predicted secretion signal peptide. Among these, several were homologous with known effectors in other nematode species; other unknown, potentially secreted proteins may have a role as root-knot nematode effectors that are induced by plant lipid signals. These include effectors functioning in the manipulation of plant defense signaling and root lipidomics, cell-wall weakening, detoxifying the stressful environment at the plant-nematode interface, allowing feeding site construction and development.
Conclusions:
Being an integral part of the plant's defense response, oxylipins may play an important signaling role in the regulation of nematode effectors. Herein we uncover activation of specific oxylipins signaling pathways upon nematode infection, which in turn

result in reprogramming the nematode effector repertoires responsible for promotion of feeding site construction and nematode parasitism.
Adequacy and complication rates of percutaneous renal biopsy on native kidneys in Chinese with 18- vs. 16-gauge needles
Authors: Xie Weiji , Xu Jing , Xie Yi , Lin Zhijun , Xu Xiaochang , Zhang Yimin 
Published: August 2019

Abstract
Aim: The study aims to compare the adequacy, complication and pathological classification rates of using 18G vs. 16G needles to perform renal biopsy with ultrasound-guided on native kidneys in Chinese. Methods: We retrospectively analyzed the number of glomeruli, adequate sample rates, complication rates and pathological classification in 270 patients who were used by 18G or 16G needles separately from January, 2011 to May, 2017，and verified whether the needle gauge affect the diagnosis of the disease. Results: A total of 270 kidney biopsies were performed. Among them :72 were with 18G needles, and 198 were with16G needles. There was no difference in the number of glomeruli count under light microscope using 18G relative to 16G needles（24±11vs25±11，p=0.265）, whereas more glomeruli count were found for the 16G group using immunofluorescence microscopy(3±2 vs 5±3， p＜0.05).There was no significant difference in the adequate sample rates between 18G group and 16G group (90.28%vs93.94%, p=0.298). Minor complications including the incidence of lumbar or abdominal pain (4.17% vs 7.07%, p = 0.57), gross hematuria (4.17% vs 3.54%, p = 0.729), and perinephric hematoma without symptoms (4.17% vs1.52%, p = 0.195) were not significantly different for 18G vs 16G group. In 16G group, there was 2 cases of serious complications occurred, including severe gross hematuria requiring blood transfusion, and retroperitoneal hematoma requiring surgery. No serious complications were observed in the 18G group, even although there was no significant difference in serious complications rates between the 18G and 16G group (0% vs 1.02%，p = 1). Conclusion: There was no significant difference in the number of glomeruli, adequate sample rates, and complication rates of using the 18G and 16G needles to perform renal biopsy, and the 18G needle with smaller diameter did not affect the pathological diagnosis and classification of IgA nephropathy and lupus nephritis.
Magnitude of iodine deficiency disorder and associated factors in Dawro zone, southwest Ethiopia: the hidden hunger
Authors: Asfaw Agize , Belachew Tefera 
Published: August 2019

Abstract
Background: Iodine deficiency disorder (IDD) is continued to be a major public health problem in Ethiopia. The problem is worse but the data is scarce in some pocket areas of the country. This study was aimed to assess the magnitude of IDD and associated factors in southwest Ethiopia by using different biochemical and clinical indicators.
Methods: Both community and school based cross- sectional study was conducted on school age children (6-12 years) from March 1 to 24, 2017. Simple random and systematic sampling techniques were applied to select districts and eligible children respectively. Household data was collected from children’s primary care takers by using structured questionnaire. A trained emergency surgeon examined children for goiter. Urine sample was collected from 20% of children (n=130).
Results: A total of 652 school children were participated in the study. Total goiter rate and median urinary iodine concentration (UIC) was 54.8 % and 96.12μg/l respectively. In multivariate logistic regression analyses student’s age was significantly (P<0 05) associated with both goiter and median UIC. However; sex of students and family income were significantly (P<0.001) associated with goiter and cassava consumption was significantly (P<0.001) associated with UIC.
Conclusion: As indicated by the median UIC, there was mild iodine deficiency in this study community. However; chronic iodine deficiency was still a severe public health problem (high goiter prevalence). In addition, there was low concentration of iodine in the salt and increased cassava cultivation and consumption in the area. Therefore, it is necessary to intensify IDD elimination activities along with teaching communities on techniques of cassava processing for household consumption.
Trial registration: PACTR201809544276357. Retrospectively registered on 14 Sept 2018.
Fluoxetine treatment for more than 2 days decreases the cellular neuroplasticity and microtubule plasticity in differentiated PC12 cells
Authors: Wu Zuotian , Wang Gaohua , Wang Huiling , Xiao Ling , Wei Yanyan , Yang Can 
Published: August 2019

Abstract
Background: Recent studies indicate that antidepressants treatment restores neuroplasticity. But some researchers claimed that antidepressants, including fluoxetine (FLU), may exacerbate neuroplasticity, which is contradictory and rarely studied. Since almost all of those studies treated with drugs for 1 to 2 days as treatment models of antidepressants, it is possible that FLU treatments for longer periods would have opposite effects on neuroplasticity.
Results: In the present study, we examined the effects of FLU treatment up to 3 days on the cellular neuroplasticity and microtubule plasticity in PC12 cells. The cell viability of cells happened a small decease at 2 days (93.5±3.5%), followed by highly significant decreases at 3 days (71.4±4.4%). As report previously, cellular neuroplasticity was significantly upregulated with FLU treatment at 1 day, but that was inhibited FLU treatment at 3 days. Similarly, the expression of tubulin, which is microtubulin plasticity marker, was also upregulated with FLU treatment at 1 day. But it decreased significantly in cells treated with FLU at 3 days. Furthermore, we found tubulin interacted with CRMP2, which accelerated to cellular neuroplasticity, and the regulation of CRMP2 activity influenced microtubule plasticity.
Conclusions: The results demonstrate that cellular neuroplasticity and microtubule plasticity were increased with FLU treatment at 1 day, but treatment with FLU for more than 2 days has opposite effect on them. The reduction in cellular neuroplasticity andmicrotubule plasticity with FLU treatment for more than 2 days might be involved in some aspects of the drugs’ therapeutic effects on depression.
Altered somatosensory evoked potentials associated with improved reaction time in a simple sensorimotor response task following repetitive practice
Authors: Akaiwa Mayu , Iwata Koki , Saito Hidekazu , Sasaki Takeshi , Sugawara Kazuhiro 
Published: August 2019

Abstract
Background Repetitive practice of sensorimotor tasks is widely used for neurorehabilitation; however, it is unknown how practice alters sensory processing (e.g., recognition, discrimination, and attentional allocation) and associated cognitive processing, such as decision-making. The purpose of this study was to investigate whether somatosensory evoked potentials (SEPs) reflecting sensory processing, attention, and decision-making are altered by sensorimotor learning. 15 participants preformed a simple sensorimotor response task (thumb opposition in response to surface electrical stimulation), with experimental recording sessions before and after three days of practice. We then compared multiple SEP waveforms and reaction times (RTs) between pre- and postpractice trials. Results As expected, the RT was reduced after practice of three days, and this was associated with shorter N140 and N250 latencies and larger P300 amplitude. Conclusions The present study suggests that motor learning improves somatosensory processing and attentional allocation via neuroplasticity and that these alterations are reflected by specific SEP changes.
Changes in the level of nursing students’ empathy during four years education
Authors: Kesbakhi Maryam Sedaghati , Rohani Camelia 
Published: August 2019

Abstract
Background: A review of previous studies on nursing students’ empathy showed contradictory results with reducing or increasing empathy in nursing students and other students in the healthcare field during academic years of education at the university. Methods: The descriptive study with comparative design was conducted to determine the level of empathy and its changes in 122 undergraduate nursing students from the first to the fourth year of study. The data were collected using Jefferson Scale ofPhysician Empathy Nursing Student Version-R (JSE- NS version R) . Data were analyzed with descriptive and analytical tests by SPSS version 20. Results: Results showed that the mean score of empathy in all nursing students was 91.8 ± 28.7 (range: 20-140). Changes of empathy across the academic education years indicated that it was significantly declined in the fourth year of education, compared to the first year (p<0.001). The mean score of empathy in more than 76% of nursing students in the fourth academic education year was set at less than 50 th percentile. Conclusions: Based on this significant reduction, it is recommended that the reasons are explored by qualitative studies. Also, empathy is introduced to the nursing students, as one of the standards of clinical competency using strategies, such as education for empathic communication with the patient in training programs, and in the core courses of the nursing profession.