bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introduction and uptake of electronic growth charts in southern New Zealand
Authors: Dainty Gloria J , Reith David M , Taylor Barry J 
Published: September 2018

AimThe introduction of an electronic system for recording and displaying growth measurements replaces multiple paper growth charts and theoretically improves the availability and consistency of information to support clinical decision‐making. Introducing this in a single New Zealand District Health Board provided the opportunity to evaluate usage in hospital settings and determine the uptake of growth recording in a defined population.MethodsAll records between 2010 and 2015 in the Southern District Health Board (SDHB) anthropometry database were downloaded and examined in a retrospective cohort analysis. Records were extracted after matching to demographic and clinical setting data from the hospital patient management system.ResultsAnalysis included 30 670 data entry points, representing 8551 children. Data entry increased over time to a maximum of 8407 observations in 2015. By the fifth year of use, up to 67% of available clinical encounters had anthropometry recorded in the outpatient department. Rates were lower in the inpatient setting, where only up to 18.4% had anthropometry recorded. The errors identified were low (0.2% of all data). Weight was the most commonly recorded measurement (98.2% of anthropometry entries, 35.1% of available clinical presentations). Height was available for 82.6% of entries and 29.5% of presentations. A body mass index z‐score was available for 81.5% of entries and 29.1% of presentations. A head circumference was available for 50.2% of children <2 years age who had anthropometry recorded.ConclusionsThe introduction of an electronic anthropometry database has been successful with increasing rates of use over time, especially in outpatient clinics. Further focus to improve inpatient recording of height and weight is needed.
The role of skin testing and extended antibiotic courses in assessment of children with penicillin allergy: An Australian experience
Authors: Arnold Annabelle , Sommerfield Aine , Ramgolam Anoop , Rueter Kristina , Muthusamy Saravanan , Noble Valerie , von Ungern‐Sternberg Britta S , Lucas Michaela 
Published: September 2018

AimTo determine if skin testing (ST) in addition to extended oral provocation challenge (OPC) is necessary for beta‐lactam allergy verification in an Australian paediatric population.MethodsThis was a retrospective study (176 children) that undertook assessments for beta‐lactam allergy from 2006 to 2015 at a tertiary paediatric hospital. Patients either underwent direct OPC without ST or ST plus challenge if ST was negative.ResultsThe analysis included children with a history of varying rash types/severity as well as angioedema and reported anaphylaxis. A direct OPC was undertaken in 73 children. Three children reacted with one anaphylaxis. A total of 103 children underwent ST, with 13 children (12.6%) reacting. Of the 90 who subsequently proceeded to OPC, 4 reacted. A total of 132 children were given an extended oral course of the culprit antibiotic, to which 6 children reacted.ConclusionsA direct OPC with the culprit drug in Australian children can be safely performed, avoiding resource‐intensive and painful ST. Our data demonstrate that a prior history of anaphylaxis does not necessarily predict IgE‐mediated allergy, as detected by positive immediate ST or reactions to oral challenge. Such history should not detract from efforts to assess these children for antibiotic allergy. We suggest that extended courses of at least 5 days are important in paediatric antibiotic de‐labelling as six children (4.5% of those who were prescribed the extended course) reacted in our study and even developed symptoms late in the extended course, from days 2 to 6.
The addition of metronomic chemotherapy does not improve outcome for canine splenic haemangiosarcoma
Authors: Alexander C. K. , Cronin K. L. , Silver M. , Gardner H. L. , London C. 
Published: September 2018

ObjectivesTo determine whether the addition of metronomic chemotherapy improved outcome for dogs with splenic haemangiosarcoma treated with splenectomy and adjuvant maximum tolerated dose chemotherapy.Materials and MethodsMedical records were examined retrospectively for dogs with splenic haemangiosarcoma that had undergone splenectomy followed by anthracycline‐based chemotherapy. Thirty‐nine dogs underwent splenectomy followed by maximum tolerated dose chemotherapy with an anthracycline, cyclophosphamide, or both (Group 1). Twenty‐two dogs underwent splenectomy followed by adjuvant maximum tolerated dose chemotherapy with an anthracycline, cyclophosphamide, or both, plus metronomic chemotherapy (Group 2). Dogs in both groups were further separated into those treated with either maximum tolerated dose anthracycline or maximum tolerated dose anthracycline and cyclophosphamide.ResultsMedian progression‐free survival was 165 days and median overall survival time was 180 days in Group 1. Median progression‐free survival was 185 days and median overall survival time was 212 days in Group 2. In both groups, the overall survival was shorter in dogs that had received maximum tolerated dose cyclophosphamide.Clinical SignificanceThe addition of metronomic to maximum tolerated dose chemotherapy protocols does not appear to improve outcome in dogs with splenic haemangiosarcoma treated with splenectomy and maximum tolerated dose chemotherapy.
Distributed Attention: A Cognitive Ethnography of Instruction in Sport Settings
Authors: Muntanyola‐Saura Dafne , Sánchez‐García Raúl 
Published: September 2018

AbstractHow do expert trainers and athletes instruct and attend to new moves? The objective of this paper is to analize communication patterns in sports settings. We propose a pragmatic view on cognition through an integrated theoretical model. We claim that communication modalities cannot be reduced to individual minds but must be understood as distributed cognitive mechanisms among different individuals and resources. We compare two case studies, an aikido session in the USA and Olympic synchronized swimming training in Spain with a video‐aided cognitive ethnography and Conversation Analysis. By exploring these specific events we have a better understanding how athletes attend to instructions by using multiple modalities. Our findings show how trainers and athletes communicate augmented information that is not available in a self‐exploratory performance. They rely on augmented information through speech, but also gesture, marking, direction of gaze and body posture. Moreover, the skills of trainers and trainees include embodied and epistemic actions. They share visual assumptions on which are the right moves. Distributed attention is at the roots of these shared and embodied skills. Distributed attention is a type of distributed cognition in sports trainings.
Development and pretesting of “Becoming Breastfeeding Friendly”: Empowering governments for global scaling up of breastfeeding programmes
Authors: Hromi‐Fiedler Amber J. , dos Santos Buccini Gabriela , Gubert Muriel Bauermann , Doucet Katie , Pérez‐Escamilla Rafael 
Published: September 2018

AbstractScaling up breastfeeding programmes has not been highly prioritized despite overwhelming evidence that breastfeeding benefits the health of mothers and children. Lack of evidence‐based tools for scaling up may deter countries from prioritizing breastfeeding. To fill this gap, Becoming Breastfeeding Friendly (BBF) was developed to guide countries in effectively scaling up programmes to protect, promote, and support breastfeeding. BBF includes an evidence‐based toolbox that consists of a BBF Index, case studies, and a 5‐meeting process. These three interrelated components enable countries to assess their breastfeeding scaling up environment, identify gaps, propose policy recommendations, develop a scaling up plan, and track progress. The toolbox was developed based on current evidence and expert guidance from a Technical Advisory Group, which was composed of global breastfeeding and metric experts with experience in the scaling up of health and nutrition programmes in low‐, middle‐, and high‐income countries. The BBF toolbox required a step‐by‐step iterative approach to describe and systematize each component, thus an operational manual was developed. The BBF toolbox and BBF operational manual underwent intensive pretesting in two countries, Ghana and Mexico, resulting in the modification of each component plus the operational manual. Pretesting continues in six additional countries demonstrating that BBF is a robust and dynamic multi‐sectoral process that, with relatively minor adaptations, can be successfully implemented in countries across world regions.
Ethnographic Objects on The Cold War Front: The Tangled History of a London Museum Collection
Authors: Buchczyk Magdalena 
Published: September 2018

AbstractThis article addresses the historical context of a museum collection of Romanian artifacts in light of British–Romanian diplomacy. The museum's holdings are unpacked through a study of the events that led to their acquisition in the 1950s. It is argued that the ethnographic investigation of the historical and political landscape in which the collection emerged reveals the importance of the collection’s performance on the Cold War cultural stage, where acts of exhibiting museum artifacts across the Iron Curtain served to create certain representations of the modern state. Particular attention is paid to the often‐overlooked European folk art collections residing in European ethnographic museums. The history of the Romanian collection held by the Horniman Museum of London (UK) demonstrates that an anthropological critique of these holdings can help explore the complex histories and the political relations that underpinned the movement and display of folk artifacts across the Iron Curtain. [Cold War, museum ethnography, state, Romania, Britain]
Role of social normative beliefs as a moderating factor in smoking intention among adolescent girls in Korea
Authors: Ra Jin Suk , Cho Yoon Hee 
Published: September 2018

AbstractIn this study, we investigated the relationship between risk‐taking tendency and smoking intention as moderated by social normative beliefs among Korean female adolescents. A cross‐sectional study was conducted with 274 female adolescents in middle school. Multiple regression and simple slope analyses were employed to test the moderating effects of social normative beliefs regarding smoking on the relationship between risk‐taking tendency and smoking intention. Results determined that risk‐taking tendency, social normative beliefs regarding smoking, and their interaction were significant factors influencing smoking intention among adolescents. Risk‐taking tendency was associated with greater smoking intention among adolescents, with higher than average social normative beliefs regarding smoking. However, risk‐taking tendency was not significantly associated with smoking intention for adolescents with lower than average social normative beliefs regarding smoking. In conclusion, social normative beliefs regarding smoking moderated the relationship between risk‐taking intention and smoking intention among Korean female adolescents. Unique sociocultural perceptions about smoking behaviors of adolescents need to be reflected in smoking‐prevention and ‐cessation programs.
How to Know That Time Travel Is Unlikely Without Knowing Why
Authors: Elliott Katrina 
Published: September 2018

AbstractWhat's the point of time travel? Not to change the past; no matter how carefully a time traveler plans, all of her attempts to change the past end in failure. Paul Horwich has argued that the implausibility of such failures gives us reason to doubt that there will be frequent time travel to the local past. I defend a modified version of Horwich's argument and show how we might gain evidence about the chance of there being frequent time travel in the future without having any information that explains why that chance value obtains.
Introduction to the Special Issue on Perspectives on Big Data
Authors: Singhal Kalyan , Feng Qi , Ganeshan Ram , Sanders Nada R. , Shanthikumar J. George 
Published: September 2018

Big data has the potential of offering valuable insights into the way organizations function, and it is changing the way organizations make decisions. Nine invited essays provide a wide range of perspectives on the role of big data in customer‐driven supply chains, healthcare operations, retail operations, demand planning and manufacturing, environmental and social issues, humanitarian operations, agriculture supply chains, and service operations. Decision makers should have clean, valid, and reliable data, and they should have a thorough understanding of the contexts of applications. Big data shorten virtual distance to customers, and thus facilitate personalization of products and services. Successful implementation of big data applications requires sharing the data with appropriate stakeholders.
Circulating plasma microRNAs as biomarkers for iron status in blood donors
Authors: Gunnarsdottir M. G. , Jonsson T. , Halldorsdottir A. M. 
Published: September 2018

SUMMARYObjectivesTo investigate whether microRNAs can serve as biomarkers for iron status in blood donors.BackgroundSerum ferritin is a widely used biochemical test for detecting iron deficiency, but it has its limitations. Certain microRNAs (miRNAs) reportedly have a role in regulating iron homeostasis. Circulating miRNAs have been reported as potential biomarkers for various conditions but have not yet been studied in iron deficiency.MethodsParticipating blood donors were divided into two groups: high ferritin (HF) (>150 µg L−1) and low ferritin (LF) (<15 µg L−1). MiRNA analysis was performed by an miRNA profiling service (Exiqon) using commercial qPCR assays. The study had two phases: (i) a pilot study (20 participants) where 179 miRNAs were analysed and (ii) a confirmation study (50 participants) of 13 selected miRNAs.ResultsMean serum ferritin was 13·8 µg L−1 in the LF arm compared to 231 µg L−1 in the HF group (P < 0·001). Hepcidin plasma levels were higher in the HF arm (P < 0·001), whereas soluble transferrin receptor 1 was higher in the LF group (P < 0·001). In the pilot study, samples did not separate according to study group on unsupervised analysis. When directly comparing HF vs LF groups, 17 miRNAs were differentially expressed (P < 0·05, t‐test) but did not pass correction for multiple testing. The confirmation study of 13 selected miRNAs verified these findings as no miRNA was significantly different between the study groups.ConclusionIn this study, circulating plasma miRNAs did not emerge as promising biomarkers for iron status in healthy individuals. However, in the future, alternative detection methods such as next‐generation sequencing might indicate miRNAs that correlate with iron stores.
Recurrent cortical circuits implement concentration-invariant odor coding
Authors: Bolding Kevin A. , Franks Kevin M. 
Published: September 2018

Representing the identity of a smell
We still don't know how odors retain their identities over a range of concentrations. Working in mice, Bolding and Franks simultaneously recorded spiking activity from neurons in the olfactory bulb and piriform cortex, two important brain regions for olfaction. Odor information was transformed from a representation that was highly concentration dependent in the olfactory bulb to a representation that was largely concentration invariant in the piriform cortex. The underlying mechanism involves a “winner-takes-all” lateral inhibition. In the collateral network of the piriform cortex, the principal cells responded promptly to output from the olfactory bulb, and recurrent inhibition curtailed the intensity dependence of the signal.

Science
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eaat6904
A continental system for forecasting bird migration
Authors: Van Doren Benjamin M. , Horton Kyle G. 
Published: September 2018

Bird forecast
Billions of birds migrate across the globe each year, and, in our modern environment, many collide with human-made structures and vehicles. The ability to predict peak timing and locations of migratory events could greatly improve our ability to reduce such collisions. Van Doren and Horton used radar and atmospheric-condition data to predict the peaks and flows of migrating birds across North America. Their models predicted, with high accuracy, patterns of bird migration at altitudes between 0 and 3000 meters and as far as 7 days in advance, a time span that will allow for planning and preparation around these important events.

Science
, this issue p.
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Protein intake in the early recovery period after exhaustive exercise improves performance the following day
Authors: Sollie Ove , Jeppesen Per B. , Tangen Daniel S. , Jernerén Fredrik , Nellemann Birgitte , Valsdottir Ditta , Madsen Klavs , Turner Cheryl , Refsum Helga , Skålhegg Bjørn S. , Ivy John L. , Jensen Jørgen 
Published: September 2018

The aim of the present study was to investigate the effect of protein and carbohydrate ingestion during early recovery from exhaustive exercise on performance after 18-h recovery. Eight elite cyclists (V̇o2max: 74.0 ± 1.6 ml·kg−1·min−1) completed two exercise and diet interventions in a double-blinded, randomized, crossover design. Participants cycled first at 73% of V̇o2max (W73%) followed by 1-min intervals at 90% of V̇o2max until exhaustion. During the first 2 h of recovery, participants ingested either 1.2 g carbohydrate·kg−1·h−1 (CHO) or 0.8 g carbohydrate + 0.4 g protein·kg−1·h−1 (CHO + PROT). The diet during the remaining recovery period was similar for both interventions and adjusted to body weight. After an 18-h recovery, cycling performance was assessed with a 10-s sprint test, 30 min of cycling at W73%, and a cycling time trial (TT). The TT was 8.5% faster (41:53 ± 1:51 vs. 45:26 ± 1:32 min; P < 0.03) after CHO + PROT compared with CHO. Mean power output during the sprints was 3.7% higher in CHO + PROT compared with CHO (1,063 ± 54 vs. 1,026 ± 53 W; P = 0.01). Nitrogen balance in the recovery period was negative in CHO and neutral in CHO + PROT (−82.4 ± 11.5 vs. 7.0 ± 15.4 mg/kg; P < 0.01). In conclusion, TT and sprint performances were improved 18 h after exhaustive cycling by CHO + PROT supplementation during the first 2 h of recovery compared with isoenergetic CHO supplementation. Our results indicate that intake of carbohydrate plus protein after exhaustive endurance exercise more rapidly converts the body from a catabolic to an anabolic state than carbohydrate alone, thus speeding recovery and improving subsequent cycling performance. NEW & NOTEWORTHY Prolonged high intensity endurance exercise depends on glycogen utilization and high oxidative capacity. Still, exhaustion develops and effective recovery strategies are required to compete in multiday stage races. We show that coingestion of protein and carbohydrate during the first 2 h of recovery is superior to isoenergetic intake of carbohydrate to stimulate recovery, and improves both endurance time-trial and 10-s sprint performance the following day in elite cyclists.
Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma
Authors: Spel Lotte , Nieuwenhuis Joppe , Haarsma Rianne , Stickel Elmer , Bleijerveld Onno B. , Altelaar Maarten , Boelens Jaap Jan , Brummelkamp Thijn R. , Nierkens Stefan , Boes Marianne 
Published: September 2018

Abstract

Neuroblastoma is the second most common tumor in children. The cause of neuroblastoma is thought to lie in aberrant development of embryonic neural crest cells and is accompanied by low MHC-1 expression and suppression of the NF-κB transcription factor, thereby gearing cells toward escape from immunosurveillance. Here, we assess regulation of the MHC-1 gene in neuroblastoma to enhance its immunogenic potential for therapeutic T-cell targeting. A genome-wide CRISPR screen identified N4BP1 and TNIP1 as inhibitory factors of NF-κB-mediated MHC-1 expression in neuroblastoma. Patients with advanced stage neuroblastoma who expressed high levels of TNIP1 and N4BP1 exhibited worse overall survival. Depletion of N4BP1 or TNIP1 increased NF-κB and MHC-1 expression and stimulated recognition by antigen-specific CD8+ T cells. We confirmed that TNIP1 inhibited canonical NF-κB member RelA by preventing activation of the RelA/p50 NF-κB dimer. Furthermore, N4BP1 inhibited both canonical and noncanonical NF-κB through binding of deubiquitinating enzyme CEZANNE, resulting in stabilization of TRAF3 and degradation of NF-κB-inducing kinase NIK. These data suggest that N4BP1/CEZANNE or TNIP1 may be candidate targets for immunotherapy in neuroblastoma tumors and should lift NF-κB suppression, thereby triggering increased peptide/MHC1-mediated tumor reactivity to enhance therapeutic T-cell targeting.

Significance:
Aberrant regulation of NF-κB and MHC-1 in neuroblastoma tumors provides new targets for immunotherapeutic approaches against neuroblastoma.
Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression
Authors: Rogers Thomas J. , Christenson Jessica L. , Greene Lisa I. , O'Neill Kathleen I. , Williams Michelle M. , Gordon Michael A. , Nemkov Travis , D'Alessandro Angelo , Degala Greg D. , Shin Jimin , Tan Aik-Choon , Cittelly Diana M. , Lambert James R. , Richer Jennifer K. 
Published: September 2018

Abstract

Tryptophan-2,3-dioxygenase (TDO2), a rate-limiting enzyme in the tryptophan catabolism pathway, is induced in triple-negative breast cancer (TNBC) by inflammatory signals and anchorage-independent conditions. TNBCs express extremely low levels of the miR-200 family compared with estrogen receptor–positive (ER+) breast cancer. In normal epithelial cells and ER+ breast cancers and cell lines, high levels of the family member miR-200c serve to target and repress genes involved in epithelial-to-mesenchymal transition (EMT). To identify mechanism(s) that permit TNBC to express TDO2 and other proteins not expressed in the more well-differentiated ER+ breast cancers, miRNA-200c was restored in TNBC cell lines. The data demonstrate that miR-200c targeted TDO2 directly resulting in reduced production of the immunosuppressive metabolite kynurenine. Furthermore, in addition to reversing a classic EMT signature, miR-200c repressed many genes encoding immunosuppressive factors including CD274/CD273, HMOX-1, and GDF15. Restoration of miR-200c revealed a mechanism, whereby TNBC hijacks a gene expression program reminiscent of that used by trophoblasts to suppress the maternal immune system to ensure fetal tolerance during pregnancy.

Implications:
Knowledge of the regulation of tumor-derived immunosuppressive factors will facilitate development of novel therapeutic strategies that complement current immunotherapy to reduce mortality for patients with TNBC.