bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is tamoxifen good enough for the Asian population in ER+ HER2- post-menopausal women with early breast cancer? A nationwide population-based cohort study
Authors: Chang Chuan-Hsun , Lee Yi-Chan , Huang Chun-Wen , Lu You-Min 
Published: November 2024

Background
Numerous clinical trials have compared the efficacy of endocrine therapy in post-menopausal breast cancer patients. This study aims to explore whether there is a difference in recurrence rates between this population using tamoxifen and aromatase inhibitors (AIs) by analyzing real-world data.

Methods
This retrospective cohort study utilized the National Health Insurance (NHI) claims data and the Taiwan Cancer Registry (TCR). We identified 6,050 patients aged over 55 diagnosed with ER-positive, HER2-negative early breast cancer between 2012 and 2016 (4,451 on AIs alone and 1,599 on tamoxifen alone). Recurrence in both groups was assessed until the end of 2020. Hazards were measured based on age of diagnosis, cancer stage, adjuvant chemotherapy, radiation therapy, type of endocrine therapy used, and adherence. Recurrence‑free survival between the AIs and tamoxifen groups was evaluated using the Kaplan-Meier model.

Results
The average age was 65.1 years, with a median follow-up time of 5.7 years and a median duration of endocrine therapy of 4.5 years. The recurrence rate was 2.2%. Using tamoxifen as endocrine therapy reduces the risk of recurrence compared to AIs (adjusted HR: 0.32, p < 0.0001). There was no statistical difference between the two drugs in stage 1 breast cancer. However, in stage 2, the risk of breast cancer recurrence decreased to 0.15 times with the use of tamoxifen compared to AIs (p = 0.0002). Stage 2 cancer, histological grade 3, and non-adherence increased recurrence risk in post-menopausal breast cancer patients.

Conclusion
Based on real-world data analysis, in ER-positive, HER2-negative post-menopausal women with early breast cancer in Taiwan, the use of tamoxifen compared to AIs is associated with a lower risk of recurrence. Improved adherence to medication can break the cycle of recurrence and improve health outcomes.
CDC’s Core Elements to promote diagnostic excellence
Authors: Morgan Daniel J. , Singh Hardeep , Srinivasan Arjun , Bradford Andrea , McDonald L. Clifford , Kutty Preeta K. 
Published: November 2024

Abstract
Nearly a decade after the National Academy of Medicine released the “Improving Diagnosis in Health Care” report, diagnostic errors remain common, often leading to physical, psychological, emotional, and financial harm. Despite a robust body of research on potential solutions and next steps, the translation of these efforts to patient care has been limited. Improvement initiatives are still narrowly focused on selective themes such as diagnostic stewardship, preventing overdiagnosis, and enhancing clinical reasoning without comprehensively addressing vulnerable systems and processes surrounding diagnosis. To close this implementation gap, the US Centers for Disease Control and Prevention (CDC) released the Core Elements of Hospital Diagnostic Excellence programs on September 17, 2024. This initiative aligns with the World Health Organization’s (WHO) 2024 World Patient Safety Day focus on improving diagnosis. These Core Elements provide guidance for the formation of hospital programs to improve diagnosis and aim to integrate various disparate efforts in hospitals. By creating a shared mental model of diagnostic excellence, the Core Elements of Diagnostic Excellence supports actions to break down silos, guide hospitals toward multidisciplinary diagnostic excellence teams, and provide a foundation for building diagnostic excellence programs in hospitals.
Paiján obsidian points on the coastal desert of southern Peru and their source
Authors: Dulanto Jalh , Pérez-Balarezo Antonio , Briceño Jesús , Yataco Juan , Silva Edwin , Icochea Abel , Tarrillo Dany , Vergara Daniel 
Published: November 2024

Abstract
Limited research exists on preceramic sites in south-central coastal Peru. Systematic survey and excavations at Pampa Lechuza, Ica, now confirm a Late Pleistocene–Early Holocene Paiján (13 000–9000 cal BP) occupation and identify Quispisisa-sourced obsidian Paiján points, which are the only examples currently known to use this raw material.
O PRÉDIO DO ARSENAL DE GUERRA DE PORTO ALEGRE E A GUERRA DA TRÍPLICE ALIANÇA E O PARAGUAI: (NOVAS) NARRATIVAS HISTÓRICAS E RESSIGNIFICAÇÃO DO PATRIMÔNIO EDIFICADO
Authors: Bett Ianko , Laux Paola Natalia 
Published: November 2024

The war arsenal building in Porto Alegre and the Triple Alliance War and Paraguay: (NEW) Historical Narratives and resignification of built assetsResumo: O artigo tem o objetivo de, em seu escopo mais amplo, identificar aspectos da historicidade da edificação que foi sede do Arsenal de Guerra de Porto Alegre (atuais instalações do Museu Militar do Comando Militar do Sul), colocando em perspectiva suas principais funcionalidades ao longo dos seus mais de 150 anos de existência, com ênfase na participação direta dessa organização militar naquele que até hoje é considerado o maior conflito já realizada em solo sul-americano: a guerra entre a Tríplice Aliança e o Paraguai. A análise foi conduzida pelo arcabouço teórico instrumentalizado pelos estudos e pesquisas oriundos da denominada “Nova História Militar” a fim de compreender o processo de patrimonialização dos bens culturais militares, no caso específico o prédio atual do Museu Militar, e a sua interface com a análise das narrativas históricas de uma das instituições militares das quais foi suporte (Arsenal de Guerra). O resultado de pesquisa apresentado poderá influenciar diretamente no desenvolvimento da história e na recomposição de novas narrativas ligadas a essa estrutura, estabelecendo novos significados e novas possibilidades com que esse local poderá ser narrado e lembrado no futuro.Palavras-chave: Arsenal de Guerra; Guerra Tríplice Aliança, Narrativas históricas; Patrimonialização Abstract: The article aims, in its broader scope, to identify aspects of the historicity of the building that was the headquarters of the Arsenal de Guerra de Porto Alegre (current installations of the Military Museum of the Southern Military Command), putting its main features into perspective throughout of its more than 150 years of existence, with emphasis on the direct participation of this military organization in what is still considered the biggest conflict ever carried out on South American soil: the war between the Triple Alliance and Paraguay. The analysis was conducted by the theoretical framework instrumentalized by studies and research from the so-called "New Military History" in order to understand the process of patrimonialization of military cultural assets, in the specific case the current Military Museum building, and its interface with the analysis of historical narratives of one of the military institutions he supported (Arsenal de Guerra). The research result presented may directly influence the development of the story and the recomposition of new (and legitimate) narratives linked to this structure, establishing new meanings and new possibilities with which this place can be narrated and remembered in the future.Keywords: Arsenal de Guerra; Triple Alliance War; Historical Narratives; PatrimonializationArtigo recebido em 23 de julho de 2021 e aprovado em 01 de novembro de 2021.
Perfil de profissionais e organização do trabalho em centrais de transplantes / Profile of professionals and organization of work in transplant centers
Authors: Lima Pestana Magalhães Aline , Dos Santos Rosane Lucilene , Da Silva Knihs Neide , Erbs Pessoa João Luis , Cavalcanti de Farias Brehmer Laura , Costa Bortolon Melo Polianna 
Published: November 2024

Objetivo: identificar o perfil de profissionais e a organização do trabalho nas centrais nacional e estaduais de transplante. Método: pesquisa quantitativa, descritiva, realizada com 34 profissionais das centrais de transplantes. Realizou-se coleta de dados entre junho e setembro de 2020, por meio de questionário eletrônico. Os dados foram analisados pela estatística descritiva. Resultados: as equipes de transplantes são compostas principalmente por enfermeiros (73,5%), com tempo de formação entre 11 e 20 anos (41,2%) e atuação nas centrais entre cinco e 10 anos (44,1%). As atividades de gestão foram as mais citadas, seguida pelas de educação, e por fim atividades assistenciais. Conclusão: a partir deste estudo foi possível evidenciar quem são os profissionais atuantes nas Centrais de Transplantes. O enfermeiro destaca-se como integrante das equipes das centrais. A atuação do enfermeiro no processo de doação de órgãos é de extrema importância, visto que é o gestor do cuidado. Devido a migração para o sistema OJS3, a íntegra desse artigo pode ser acessada pelo seguinte endereço eletrônico: Perfil de profissionais e organização do trabalho em centrais de transplantes | Journal of Nursing and Health (ufpel.edu.br)
Elaboração e validação do questionário de avaliação do conhecimento de enfermeiros sobre eletrocardiografia / Elaboration and validation of the questionnaire to assess nurses' knowledge about electrocardiography
Authors: Carrijo Marcos Vítor Naves , Silva Veridiana Assencio , Rempel Carla Ferreira , Silva Michele Salles da , Dessotte Carina Aparecida Marosti , Maier Suellen Rodrigues de Oliveira 
Published: November 2024

Objetivo: construir e validar o conteúdo do questionário de verificação do conhecimento de enfermeiros sobre eletrocardiograma. Método: estudo metodológico constituído por três etapas: revisão narrativa da literatura, elaboração do questionário e busca por evidências de validade de conteúdo por comitê de especialista a partir do cálculo do Índice de Validade de Conteúdo. Resultados: o “Questionário de Verificação do Conhecimento de Enfermeiros sobre Eletrocardiografia” foi elaborado a partir dos eixos norteadores: Perfil sociodemográfico, acadêmico e profissional, Conhecimento sobre a realização do eletrocardiograma e Conhecimento sobre a interpretação do eletrocardiograma, apresentando evidências de validade do conteúdo com índice de validade de conteúdo total com valor de 0,93. Conclusões: o questionário elaborado demonstrou evidências de validade de conteúdo, ancorados na tríade formação-realização-interpretação. Devido a migração para o sistema OJS3, a íntegra desse artigo pode ser acessada pelo seguinte endereço eletrônico: Elaboração e validação do questionário de avaliação do conhecimento de enfermeiros sobre eletrocardiografia | Journal of Nursing and Health (ufpel.edu.br)
In Silico Analysis of Cross-Species Sequence Variability in Host Interferon Antiviral Pathway Proteins and SARS-CoV-2 Susceptibility
Authors: Mayasich Sally A. , Schumann Peter G. , Botz Maxwell , LaLone Carlie A. 
Published: November 2024

Background:
Zoonotic transmission of severe acute respiratory coronavirus 2 (SARS-CoV-2) has been found to result in infections in more than 30 mammalian species. The SARS-CoV-2 spike protein binds to the host’s angiotensin converting enzyme 2 (ACE2) cell surface receptor to gain entry into the cell. ACE2 protein sequence conservation has therefore been evaluated across species, and species with amino acid substitutions in ACE2 were ranked low for susceptibility to SARS-CoV-2 infection. However, many of these species have become infected by the virus.

Methods:
This study investigated the conservation of 24 host protein targets, including the entry proteins ACE2 and transmembrane serine protease 2 (TMPRSS2); 21 proteins in the interferon-I (IFN-I) antiviral response pathway; and tethrin, a protein that suppresses new virion release from cells. Bioinformatics approaches including Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS), Molecular Operating Environment (MOE), and iCn3D software were used to compare protein sequence similarity, conserved domains, and critical amino acids for host-viral protein-protein interactions. The types of bonding interactions were scored, and the results were compared with empirical data indicating which species have or have not become infected.

Results:
This pathway approach revealed that 1) 13 proteins were conserved, whereas five lacked data sufficient to determine specific critical amino acids; 2) variation in protein-protein interfaces is tolerated for many amino acid substitutions, and these substitutions follow taxonomic clades rather than correlating with empirically determined species infection status; and 3) four proteins (MDA5, NEMO, IRF3, and ISG15) contained potential domains or specific amino acids whose substitution may result in PPI disruption.

Conclusion:
This work provides evidence that certain substitutions in four IFN-I antiviral pathway proteins appear able to disrupt interactions and may be distinctive to resistant species, thus potentially aiding in determining species’ likelihood of transmitting SARS-CoV-2.
“Studying & Drawing”: A Neapolitan Trip by Charles-Louis Clérisseau and Robert Adam in Light of Newly Discovered Drawings
Authors: Šverko Ana 
Published: November 2024

Abstract
This article presents a group of drawings by Charles-Louis Clérisseau from a newly discovered collection in the Bibliothèque Nationale de France. These drawings date from Clérisseau’s study trip to Naples with Robert Adam in April 1755, shortly after he became Adam’s cicerone and drawing instructor. They include studies of ancient ruins, counterparts of which can be found among Adam’s drawings from his grand tour, now held in Sir John Soane’s Museum. Situating this excursion within the artists’ careers, this new research expands on the itinerary of their shared journey and builds on our knowledge of Adam’s first steps as a student of drawing in Italy. The travel studies discussed here illustrate the training of the architect-artist in the eighteenth century, emphasizing the era’s significance for draftsmanship. By addressing these drawings in the context of learning through copying, this article furthers our understanding of the concept of copying in architectural history.
КРИТЕРИЙ ПОЛНОТЫ УСТОЙЧИВОГО ПРИРОДОПОЛЬЗОВАНИЯ
Authors: А.К. ЧЕРКАШИН 
Published: November 2024

Выделены факторы и условия формирования устойчивого природопользования по критерию полноты состава и функционирования географической системы «природа-хозяйство-население» территории. Полнота - сквозной показатель оптимальности систем разного рода на минимальном и максимальном уровне их существования и изменения в процессе сохранения природы, роста экономики и совершенствования общества. Степень полноты - вариант оценочной функции, отличающей геосистемы разных местоположений и переменных состояний по набору взаимозаменяемых влияющих факторов природного, экономического и социального происхождения и особенностей местных условий географической среды. Все наблюдаемые процессы отражают целевое стремление к совершенству в форме полноты и безопасности своего системного выражения, к идеалу существования, приоритетной цели развития, только при достижении и преодолении которой возможно устойчивое развитие. Тенденции проявления полноты выделены как верхние и нижние огибающие линии (поверхности) многообразия связи данных натурных и статистических наблюдений. Управляющие аддитивные воздействия смещают ландшафтную норму полноты разных местоположений. Необходимо учитывать специальные ограничения на степень неполноты и переполнения системных качеств. Модели и методы анализа продемонстрированы на примере восстановления запасов лесонасаждений и реализации инвестиционного процесса по регионам России.
The article highlights the factors and conditions for the formation of a regime of sustainable development of a territory with environmental management according to the criterion of completeness of the composition and functioning of geographical system ‘nature-economy-population' of the territory. Completeness is a pass-through indicator of the optimality of systems of various kinds at the minimum and maximum levels of their existence and changes in the process of nature conservation, economic growth and improvement of society. The degree of completeness is a variant of the evaluation function that distinguishes geosystems of different locations and variable states by a set of interchangeable influencing factors of natural, economic and social origin and features of local conditions of the geographical environment. All the observed processes reflect the goal of striving for perfection in the form of completeness and safety of its systemic expression, for the ideal of existence, a priority development goal, only with the achievement and overcoming of which sustainable development is possible. The trends of completeness are distinguished as the upper and lower envelope lines (surfaces) of the diversity of the connection of data from field and statistical observations. Controlling additive influences shift the landscape norm of completeness of different locations. It is necessary to take into account special restrictions on the degree of incompleteness and overflow of system qualities. Models and methods of analysis are demonstrated by the example of restoration of forest plantations and the implementation of the investment process in the regions of Russia.
СВЯЩЕННОЕ ПИСАНИЕ И СИСТЕМА ЖАНРОВ ДРЕВНЕРУССКОЙ ЛИТЕРАТУРЫ: К ПОСТАНОВКЕ ПРОБЛЕМЫ
Authors: В.А. РОМОДАНОВСКАЯ 
Published: November 2024

Система жанров древнерусской литературы, по словам Д.С. Лихачева, определялась христианским мировоззрением средневекового человека, причем формальные признаки жанров были строго регламентированы особенностями их церковного употребления. Кроме структурной характеристики жанра могут быть определены его способности к развитию и трансформации. Развитие жанра - создание новых произведений по образцу существующих, причем развитием жанра обусловлено появление и новых литературных направлений, что, в свою очередь, приводит к трансформации жанра - таком его видоизменении, когда при сохранении формальных признаков одного жанра произведение несет функциональную нагрузку другого жанра. Однако способностей развития и трансформации в древнерусской литературе лишены тексты Священного Писания, поскольку они закреплены устоявшимся христианским каноном. Будучи литературой в широком смысле, памятником письменности, Священное Писание выпадает из литературного процесса и в этом отношении литературой не является.
The Christian worldview of a medieval person, according to D.S. Likhachev, determined the system of genres of Old Russian literature, and the formal signs of genres were strictly regulated by the peculiarities of their church use. In addition to the structural characteristics of the genre, its ability to develop and transform can be determined. The development of the genre is the creation of new works on the model of existing ones, and the development of the genre causes emergence of new literary trends, which, in turn, leads to the transformation of the genre - such a modification when the work carries the functional load of another genre, while preserving the formal characteristics of original genre. The texts of Holy Scripture could develop and transform only at the initial stage of their existence - the desire to record the words of eyewitnesses of Christ in the first centuries of Christianity gave rise to an extensive literature of gospels and acts, new literary genres that generated new and new works. The rapid development of Christian literature, which took place in accordance with general literary laws, was interrupted in the middle of the 4th century with the emergence of the concept of the Christian canon, which fixed the definition of sacred only for some books of new and old, Jewish, religious literature, and attributed the rest to the number of apocrypha. In Old Russian literature, the texts of Holy Scripture are devoid of the ability to develop and transform, since they are fixed in the canon. Being literature in a broad sense and a monument of writing, the Holy Scripture falls out of the literary process and in this respect is not literature. The consequences of this position are a controlled textological tradition, codification of biblical texts, a strict attitude to quoting texts of the Holy Scripture. The change in this situation became possible only at the end of the Russian Middle Ages, with the secularization of the society.
Institutos Federais de Educação, Ciência e Tecnologia no Brasil
Authors: Silva Daliane Teixeira , Dias Edmilson Silva , Ribeiro Núbia Moura 
Published: November 2024

O objetivo deste artigo é analisar de que forma os Institutos Federais de Educação, Ciência e Tecnologia estão alcançando a finalidade, prevista em lei, de desenvolver soluções técnicas e tecnológicas. Para tanto, foi realizado um mapeamento da Propriedade Intelectual, em especial da Propriedade Industrial, com base na análise do número de pedidos de patentes, marcas, desenhos industriais e dos direitos autorais de programas de computador, no período de 2009 a 2020. As buscas foram feitas na base de dados do Instituto Nacional da Propriedade Industrial (INPI), usando as siglas dos 38 Institutos Federais, verificando-se ano de depósito/registro. Foi identificado um total de 163 pedidos de patentes e 11 de desenhos industriais; 88 registros de marcas e 133 de programas de computador. O IFBA foi o Instituto Federal com maior número de depósito para patentes, o IFS com maior número de registro de marcas, e o IFAL com maior número de registros de desenhos industriais e de programas de computador. Conclui-se que os Institutos Federais estão alcançando a finalidade prevista na lei de sua criação.
O papel da assistência estudantil frente à necessidade da garantia do direito à educação
Authors: Do Nascimento Barbosa da Rocha Virginia , Santos de Castro Raimundo 
Published: November 2024

O presente artigo discute o processo de construção da Política de Assistência Estudantil no Brasil e indica os mecanismos utilizados para garantia do direito à Educação. A partir de pesquisa bibliográfica e com a intenção de subsidiar as discussões propostas na pesquisa intitulada “Os desafios e as possibilidades da Assistência Estudantil no Instituto Federal de Educação, Ciência e Tecnologia do Piauí, Campus Teresina Central: relatos de vivência”, desenvolvida no Programa de Pós-Graduação em Educação Profissional e Tecnológica ProfEPT, do Instituto Federal de Educação, Ciência e Tecnologia do Maranhão – IFMA, traçamos o histórico desta política; delineamos a forma com que ela se configura nos diferentes Institutos Federais, trazendo as especificidades da POLAE (Política de Assistência Estudantil do IFPI), e discutimos valores e princípios que estão na base de sua constituição, além de indicar um modelo ideal de Política de Assistência Estudantil.
A avaliação da aprendizagem nos Institutos Federais em Goiás durante a pandemia
Authors: Assis Tauã Carvalho de , Lima Niele Alves 
Published: November 2024

Este trabalho busca apontar a relevância do uso de Este trabalho analisa a produção documental sobre a avaliação da aprendizagem no período de vigência do ensino remoto (2020-2021) do Instituto Federal de Educação, Ciência e Tecnologia de Goiás (IFG) e do Instituto Federal de Educação, Ciência e Tecnologia Goiano (IF Goiano). No referido período, as mencionadas instituições de ensino, em decorrência de emergência sanitária global, necessitaram transpor o ensino presencial para uma modalidade não presencial, assim como diversas instituições educacionais ao redor do mundo. A partir da metodologia da pesquisa documental, buscou-se construir um quadro de análise das concepções que respaldaram os processos de avaliação pedagógica das duas instituições. Conclui-se que as instituições buscaram garantir a avaliação formativa, contínua e processual e que priorizasse os aspectos qualitativos. Contudo, diferenciaram-se quanto às propostas de recuperação da aprendizagem.