bluuebunny/crossref_metadata_2025_split huggingface dataset:
The consequences of prolonged duration of antibiotics in premature infants with suspected sepsis in a large tertiary referral hospital
Authors: Al-Mouqdad Mountasser M. , Aljobair Fahad , Alaklobi Faisal Abduljabar , Taha Muhammed Yassen , Abdelrahim Adli , Asfour Suzan Suhail 
Published: September 2018

Objective:
To assess whether there is any association between prolonged duration of the first course of empirical antibiotic treatment for suspected neonatal sepsis and other factors including comorbidities, interventions, and adverse outcomes.

Background:
Neonatal sepsis is one of the main reasons of mortality among premature infants in Neonatal Intensive Care Unit (NICU). Therefore, commencing antibiotics treatment on admission plays a crucial role in reducing the complications of neonatal sepsis, however the arbitrary use of antibiotics holds many serious complications. In our study we investigated the complications of prolonged use of antibiotics in treating suspected early onset of sepsis.

Study design:
This is a retrospective cohort study of infants of gestational age 32 weeks or less and with birth weight of 1500 g or less along with suspected neonatal sepsis admitted to our neonatal intensive care unit from July 2015 to June 2017. The study outcome measures were the association between the antibiotic treatment duration and maternal factors, gender, adverse outcomes, developmental factors, comorbid conditions, early-onset sepsis, and late-onset sepsis.

Results:
Of 295 premature infants, late-onset sepsis was associated with the duration of early empiric antibiotic use (n = 54/295), where 50 (92.6%) infants with LOS received the antibiotic treatment for more than 5 days (P < .001). Approximately 91.2% of those receiving the prolonged treatment had a positive blood culture result. Necrotizing enterocolitis was more prevalent in those with long duration of antibiotic treatment (95.1%). Among patients with the comorbid conditions patent ductus arteriosus (n = 123/295), intraventricular hemorrhage (n = 73/295), and periventricular leukomalacia (n = 25/295), 100 (81.3%), 60 (82.2%), and 21 (84%) of them, respectively, received prolonged treatment.

Conclusion:
Prolonged administration of empiric antibiotics to infants with very low birth weight along with sterile cultures is associated with the adverse outcomes late-onset sepsis and necrotizing enterocolitis. However, no association with other adverse outcomes, namely, candidiasis or maternal factors, was found.
An exploratory look at comorbidities, utilization, and quality of care among obese and nonobese children in academic family medicine practice
Authors: Silverio Alexis , Khalili Seyed Parham , Cunningham Amy 
Published: September 2018

Background:
Obesity is one of the least addressed comorbidities among children who attend family medicine clinics. The aim of this study was to apply a population health framework to understand the differences between obese and nonobese pediatric patients in academic family medicine practice with regard to general demographics, comorbidities, and quality measures.

Methods:
Exploratory retrospective chart reviews were conducted among obese children aged 2–17 years and a random sample of age-matched nonobese children in 2015. Data were gathered through the institute's electronic medical record system and included demographics, ICD-10 diagnosis codes, outpatient primary care and specialty care visits, in-network emergency department visits, and innetwork hospital admissions.

Results:
This exploratory study suggested that the obese pediatric population (n = 213) had a high prevalence of hypertension (P = .006) and sleep apnea (P = .05) and a larger number of diagnosed comorbidities (P = .008), whereas nonobese children had a high prevalence of environmental allergies (P = .001). There were no significant differences among quality measures between obese (n = 213) and age-matched nonobese pediatric patients (n = 219).

Conclusion:
This study used readily available electronic health record data to highlight comorbidities that are more common among obese pediatric patients in academic family medicine practice, thus providing information that could potentially facilitate more timely screening and intervention.
‘The Visible Embodiment of Modern Commerce’: Speculative Office Buildings in Liverpool, c. 1780–1870
Authors: Sharples Joseph 
Published: September 2018

AbstractAs one of the world's great centres of trade, the port of Liverpool developed a dedicated office district from an early date. In the 1780s, lettable offices were built by the Corporation near the Georgian Exchange (later known as the Town Hall), making possible the separation of home and workplace. The creation of the public square called Exchange Flags, and the erection of the first Exchange Buildings (1803–08), led to the rapid concentration of business activity in the surrounding streets. Early buildings combined offices with warehousing, but changes in the cotton trade resulted in their replacement with offices only. The first major speculative block was India Buildings (1833), and its success heralded a wave of rebuilding from the 1840s to the 1860s. Many office developers were merchants, but banks and insurance companies also incorporated lettable space into their premises. Classical styles predominated, but traditional fenestration was modified to ensure good natural lighting. The result was an exceptionally imposing business district, symbolising the immense commercial importance of Victorian Liverpool.
Dance Halls: Towards an Architectural and Spatial History,c. 1918–65
Authors: Nott James 
Published: September 2018

AbstractThe dance hall was a symbol of social, cultural and political change. From the mid-1920s until the mid-1960s, the dance hall occupied a pivotal place in the culture of working- and lower-middle-class communities in Britain. Its emergence and popularity following the First World War reflected improvements in the social and economic well-being of the working and lower middle classes. The architecture of dance halls reflected these modernising trends, as well as a democratisation of pleasure. The very name adopted by the modern dance hall, ‘palais de danse’, emphasises this ambition. Affordable luxury was a key part of their attraction. This article examines how the architecture of dance halls represented moments of optimism, escapism and ‘modernity’ in British history in the period 1918–65. It provides the first overview of dance halls from an architectural and spatial history perspective.
Extreme laser pulses for non-thermal fusion ignition of hydrogen–boron for clean and low-cost energy
Authors: Hora Heinrich , Eliezer Shalom , Miley George H. , Wang JiaXiang , Xu YanXia , Nissim Noaz 
Published: September 2018

AbstractAfter achieving significant research results on laser-driven boron fusion, the essential facts are presented how the classical very low-energy gains of the initially known thermal ignition conditions for fusion of hydrogen (H) with the boron isotope 11 (HB11 fusion) were bridged by nine orders of magnitudes in agreement with experiments. This is possible under extreme non-thermal equilibrium conditions for ignition by >10 PW-ps laser pulses of extreme power and nonlinear conditions. This low-temperature clean and low-cost fusion energy generation is in crucial contrast to local thermal equilibrium conditions with the advantage to avoid the difficulties of the usual problems with extremely high temperatures.
Success in learning similar-sounding words predicts vocabulary depth above and beyond vocabulary breadth
Authors: VAN GOCH Merel M. , VERHOEVEN Ludo , MCQUEEN James M. 
Published: September 2018

AbstractIn lexical development, the specificity of phonological representations is important. The ability to build phonologically specific lexical representations predicts the number of words a child knows (vocabulary breadth), but it is not clear if it also fosters how well words are known (vocabulary depth). Sixty-six children were studied in kindergarten (age 5;7) and first grade (age 6;8). The predictive value of the ability to learn phonologically similar new words, phoneme discrimination ability, and phonological awareness on vocabulary breadth and depth were assessed using hierarchical regression. Word learning explained unique variance in kindergarten and first-grade vocabulary depth, over the other phonological factors. It did not explain unique variance in vocabulary breadth. Furthermore, even after controlling for kindergarten vocabulary breadth, kindergarten word learning still explained unique variance in first-grade vocabulary depth. Skill in learning phonologically similar words appears to predict knowledge children have about what words mean.
Disaster Risk Reduction in Schools: The Relationship of Knowledge and Attitudes Towards Preparedness from Elementary School Students in School-Based Disaster Preparedness in the Mentawai Islands, Indonesia
Authors: Sujarwo  , Noorhamdani  , Fathoni Mukhamad 
Published: September 2018

AbstractIntroductionLocated in the Sunda Megathrust zone, Mentawai Island is known as the epicenter of an active earthquake that has the potential to cause a tsunami. Students would be one of the most vulnerable groups during the disaster.ProblemThe low-level of School-Based Disaster Preparedness/Sekolah Siaga Bencana(SSB) of students’ preparedness in disaster risk reduction (DRR) can lead to increased vulnerability of students in facing disaster threats, especially a tsunami.MethodsThe study employed observational, correlative analytics with a cross-sectional approach. The sample includes 109 students from fifth and sixth grade in three elementary schools in Sipora, Mentawai Island district.ResultsThere was a significant influence between knowledge and attitude towards the preparedness of SSB students in DRR in Sipora, Mentawai Islands district.Conclusions:Knowledge and attitudes are key factors that must be taken into account in efforts to increase student preparedness to reduce the risk of a tsunami disaster.Sujarwo,Noorhamdani,Fathoni M.Disaster risk reduction in schools: the relationship of knowledge and attitudes towards preparedness from elementary school students in school-based disaster preparedness in the Mentawai Islands, Indonesia.Prehosp Disaster Med.2018;33(6):581–586.
A mixed methods analysis of perceived cognitive impairment in hematopoietic stem cell transplant survivors
Authors: Wu Lisa M. , Kuprian Nadia , Herbert Krista , Amidi Ali , Austin Jane , Valdimarsdottir Heiddis , Rini Christine 
Published: September 2018

AbstractObjectiveHematopoietic stem cell transplant (HSCT) survivors may show evidence of objective cognitive impairment; however, perceived cognitive problems and their impact on quality of life are less well-understood. The purpose of this study was to explore HSCT survivors’ perceptions of cognitive impairment and its effect on daily life functioning.MethodSixty-nine autologous and allogeneic HSCT survivors nine months to three years posttransplant experiencing mild survivorship problems completed a brief structured interview regarding perceived cognitive impairment since transplant. Data were coded and content analyzed. The frequency of participants reporting cognitive problems by domain and associations between reports of cognitive problems and age, depressed mood, anxiety, and health-related quality of life were examined.ResultOverall, 49 of the 69 participants (71%) reported cognitive impairments after transplant: 38 in memory (55%), 29 in attention and concentration (42%), and smaller numbers in other domains. There were no significant differences in problems reported by transplant type. Of the 50 participants who worked before transplant, 19 (38%) did not return to work following transplant, with 12 citing cognitive and health problems as being the reason. There were significant associations between reports of cognitive impairment and younger age (p = 0.02), depressed mood (p = 0.02), anxiety (p = 0.002), and health-related quality of life (p = 0.008).Significance of resultsA large proportion of survivors reported cognitive impairment following HSCT that impaired daily life functioning. Perceived cognitive impairment was associated with younger age, greater distress and reduced health-related quality of life.
Sprachkompetenz bei Auszubildenden mit Migrationsgeschichte in der	Altenpflege
Authors: Friedrich Anett , Morgenstern Ulrike 
Published: September 2018

Zusammenfassung. Bisher wurde die Problematik einer unzureichenden Sprachkompetenz von AMIGA1 in der Ausbildung zur Altenpflege noch nicht ausreichend untersucht. Die Sprachkompetenz ist eine wichtige Grundlage für den Aufbau und Gestaltung der Beziehung im Pflegeprozess. Für die effektive Förderung der Sprachkompetenz ist eine Vernetzung von Förder-, Deutsch- und Fachunterricht unumgänglich.
Influence of Hydrodynamic Processes on the Fate of Sedimentary Organic Matter on Continental Margins
Authors: Bao Rui , van der Voort Tessa S. , Zhao Meixun , Guo Xinyu , Montluçon Daniel B. , McIntyre Cameron , Eglinton Timothy I. 
Published: September 2018

AbstractUnderstanding the effects of hydrodynamic forcing on organic matter (OM) composition is important for assessment of organic carbon (OC) burial in marginal seas on regional and global scales. Here we examine the relationships between regional oceanographic conditions (bottom shear stress), and the physical characteristics (mineral surface area and grain size) and geochemical properties (OC content [OC%] and carbon isotope compositions [13C, 14C]) of a large suite of surface sediments from the Chinese marginal seas to assess the influence of hydrodynamic processes on the fate of OM on shallow continental shelves. Our results suggest that 14C content is primarily controlled by organo‐mineral interactions and hydrodynamically driven resuspension processes, highlighted by (i) positive correlations between 14C content and OC% (and surface area) and (ii) negative correlations between 14C content and grain size (and bottom shear stress). Hydrodynamic processes influence 14C content due to both OC aging during lateral transport and accompanying selective degradation of OM associated with sediment (re) mobilization, these effects being superimposed on the original 14C characteristics of carbon source. Our observations support the hypotheses of Blair and Aller (2012, https://doi.org/10.1146/annurev‐marine‐120709‐142717) and Leithold et al. (2016, https://doi.org/10.1016/j.earscirev.2015.10.011) that hydrodynamically driven sediment translocation results in greater OC 14C depletion in broad, shallow marginal seas common to passive margin settings than on active margins. On a global scale, this may influence the extent to which continental margins act as net carbon sources and sinks. Our findings thus suggest that hydrodynamic processes are important in shaping the nature, dynamics, and magnitude of OC export and burial in passive marginal seas.
Reevaluating Fluid Sources During Skarn Formation: An Assessment of the Empire Mountain Skarn, Sierra Nevada, USA
Authors: Ramos Evan J. , Hesse Marc A. , Barnes Jaime D. , Jordan Jacob S. , Lackey Jade Star 
Published: September 2018

AbstractOxygen isotope analyses of skarn minerals have long been used to fingerprint the variable fluid sources involved in skarn formation. The Empire Mountain skarn of the Sierra Nevada (California, USA) batholith is identified as a low‐δ18O skarn and is thought to form due to surface fluid involvement that was enhanced by fractures that formed during host rock brecciation. Although geochemically well characterized, the Empire Mountain skarn is less understood in terms of its hydrodynamic history. In this study, we develop a two‐dimensional model of oxygen isotope transport during high‐temperature fluid‐rock interactions to assess the mechanisms by which low‐δ18O garnets could form exclusive of brecciation. Highlighting regions nearest to the intrusion that could form garnet, we make three primary observations: (1) the oxygen isotope composition of the fluids, and not temperature, dominantly controls δ18Ogarnet values; (2) >6‰ increases in δ18Ogarnet, from negative to positive values, are observed over the maximum time frame of garnet thermodynamic stability; and (3) incremental emplacement of the intrusion can produce oscillations in δ18Ogarnet values. Without invoking brecciation, we find that low‐δ18O garnets can form without the presence of surface fluids; they instead source 18O‐depleted pore fluids from adjacent units. Further, surface fluids that do not equilibrate with the surrounding rock at depth become low‐δ18O fluid sources during later stages of pluton emplacement. This study underscores that pore fluids at depth, regardless of their equilibrium state, can act as dormant low‐δ18O fluid sources and may be responsible for low‐δ18O‐valued garnets.
Description of the Code ANVIL (ANisotropic Vhf Impulse Location)
Authors: Ortiz Alexander E. , Morris Heidi E. 
Published: September 2018

AbstractWe have developed a general, three‐dimensional method to locate sources of earth‐directed radiation that takes into account the flight paths of reflected signals. While time‐of‐arrival algorithms exist for locating radio sources using line‐of‐sight propagation paths, radio sources originating above the surface of the Earth will not necessarily emit strong power along direct paths to satellites. A combination of direct and ground‐reflected pulses or only ground‐reflected signals from such sources could be received by satellite‐borne sensors. The work presented here applies to satellite detection of subionospheric radio sources in a vacuum environment with ideal reflection off the Earth's surface. Because satellites are not static receivers, their configuration with respect to a radio source is not always optimal. Therefore, a statistical study is performed using 1,000 randomized configurations of 24 satellites in middle Earth orbit. For each configuration, the radio source latitude and longitude is fixed, and its altitude is varied from 1 to 97 km. An analytic direct‐path algorithm using the five satellites nearest the radio source provides an initial guess for the radio source latitude and longitude. We find that, using this approximation, the mean error in the calculated nadir location has a maximum value of 134 m for the 97‐km source altitude. The coordinates of the initial guess are used to define the origin of a grid within which an all‐points search refinement is performed. Using this procedure, the overall maximum mean error in radio source position is found to be on the order of the computational grid size.
Optical conductivity-based ultrasensitive mid-infrared biosensing on a hybrid metasurface
Authors: Zhu Yibo , Li Zhaoyi , Hao Zhuang , DiMarco Christopher , Maturavongsadit Panita , Hao Yufeng , Lu Ming , Stein Aaron , Wang Qian , Hone James , Yu Nanfang , Lin Qiao 
Published: September 2018

AbstractOptical devices are highly attractive for biosensing as they can not only enable quantitative measurements of analytes but also provide information on molecular structures. Unfortunately, typical refractive index-based optical sensors do not have sufficient sensitivity to probe the binding of low-molecular-weight analytes. Non-optical devices such as field-effect transistors can be more sensitive but do not offer some of the significant features of optical devices, particularly molecular fingerprinting. We present optical conductivity-based mid-infrared (mid-IR) biosensors that allow for sensitive and quantitative measurements of low-molecular-weight analytes as well as the enhancement of spectral fingerprints. The sensors employ a hybrid metasurface consisting of monolayer graphene and metallic nano-antennas and combine individual advantages of plasmonic, electronic and spectroscopic approaches. First, the hybrid metasurface sensors can optically detect target molecule-induced carrier doping to graphene, allowing highly sensitive detection of low-molecular-weight analytes despite their small sizes. Second, the resonance shifts caused by changes in graphene optical conductivity is a well-defined function of graphene carrier density, thereby allowing for quantification of the binding of molecules. Third, the sensor performance is highly stable and consistent thanks to its insensitivity to graphene carrier mobility degradation. Finally, the sensors can also act as substrates for surface-enhanced infrared spectroscopy. We demonstrated the measurement of monolayers of sub-nanometer-sized molecules or particles and affinity binding-based quantitative detection of glucose down to 200 pM (36 pg/mL). We also demonstrated enhanced fingerprinting of minute quantities of glucose and polymer molecules.
The intracellular signalosome of PD-L1 in cancer cells
Authors: Escors David , Gato-Cañas María , Zuazo Miren , Arasanz Hugo , García-Granda María Jesus , Vera Ruth , Kochan Grazyna 
Published: September 2018

AbstractProgrammed cell death-1 ligand-1 (PD-L1) overexpression in cancer cells accelerates tumor progression. PD-L1 possesses two main pro-oncogenic functions. First, PD-L1 is a strong immunosuppressive molecule that inactivates tumor-specific T cells by binding to the inhibitory receptor PD-1. Second, PD-L1 function relies on the delivery of intrinsic intracellular signals that enhance cancer cell survival, regulate stress responses and confer resistance toward pro-apoptotic stimuli, such as interferons. Here, we review the current knowledge on intracellular signal transduction pathways regulated by PD-L1, describe its associated signalosome and discuss potential combinations of targeted therapies against the signalosome with PD-L1/PD-1 blockade therapies.
Back-translating behavioral intervention for autism spectrum disorders to mice with blunted reward restores social abilities
Authors: Pujol Camille N. , Pellissier Lucie P. , Clément Céline , Becker Jérôme A. J. , Le Merrer Julie 
Published: September 2018

AbstractThe mu opioid receptor (MOR) plays a critical role in modulating social behavior in humans and animals. Accordingly, MOR null mice display severe alterations in their social repertoire as well as multiple other behavioral deficits, recapitulating core and secondary symptoms of autism spectrum disorder (ASD). Such behavioral profile suggests that MOR dysfunction, and beyond this, altered reward processes may contribute to ASD etiopathology. Interestingly, the only treatments that proved efficacy in relieving core symptoms of ASD, early behavioral intervention programs, rely principally on positive reinforcement to ameliorate behavior. The neurobiological underpinnings of their beneficial effects, however, remain poorly understood. Here we back-translated applied behavior analysis (ABA)-based behavioral interventions to mice lacking the MOR (Oprm1−/−), as a model of autism with blunted reward processing. By associating a positive reinforcement, palatable food reward, to daily encounter with a wild-type congener, we were able to rescue durably social interaction and preference in Oprm1−/− mice. Along with behavioral improvements, the expression of marker genes of neuronal activity and plasticity as well as genes of the oxytocin/vasopressin system were remarkably normalized in the reward/social circuitry. Our study provides further evidence for a critical involvement of reward processes in driving social behavior and opens new perspectives regarding therapeutic intervention in ASD.