bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic state uncovers prognosis insights of esophageal squamous cell carcinoma patients
Authors: Piao Hai-long , Feng Tingze , Li Pengfei , Li Siyi , Wang Yuhan , Lv Jing , Xia Tian , Lee Hoy-Jong , Chen Di , Ma Yegang 
Published: December 2024

Abstract

Background
Metabolite and protein interactions (MPIs) play vital roles in cancer metabolism; however, how MPIs orchestrate with the esophageal squamous cell carcinoma (ESCC) microenvironment remains unclear. Thus, this study aimed to investigate the metabolic landscape of the ESCC microenvironment based on the MPI network and multi-scaled transcriptomics data.
Methods
First, we characterized the metabolic states of the cells in ESCC based on single-cell transcriptome profiles of the critical metabolite-interacting proteins. Next, we defined the metabolic patterns of each ESCC patient based on the compositions of different metabolic states in the bulk sample, and the ESCC samples were clustered into distinct subtypes.
Results
As a result, sixteen ESCC metabolic states were identified. Each of the seven cell types in tumor microenvironments had disparate metabolic states, which reflected the high metabolic heterogeneity of ESCC. Four ESCC subtypes showing differences in the compositions of the metabolic states were identified, and significant differences in prognosis, clinical features, gene expressions, and pathways. Interestingly, inactivation of cellular detoxification may be related to the poor prognosis of ESCC patients.
Conclusions
Overall, we redefine robust ESCC prognosis subtypes and identify key MPI pathways in ESCC linking metabolism, thus promoting understanding and clinical applications of ESCC in metabolism heterogeneity.
Transcranial color Doppler in the assessment of cerebrovascular changes in diabetic patients: an observational cross-sectional study
Authors: Habib Asmaa , El-Kaffas Khalid , Ashraf Amira , Hassan Eman 
Published: December 2024

Abstract

Background:
Diabetes mellitus (DM) is a major independent threat for cerebrovascular disease (CVD), diabetics have a dual risk of stroke compared to nondiabetics. Transcranial Doppler (TCD) ultrasound is an easy, reliable & non-invasive method for assessing cerebral blood flow in various clinical settings including diabetic patients.
Objective
This observational cross-sectional study aimed to assess the differences in TCD measurements between diabetic patients and control subjects, and between type I and type II diabetes.
Methods
We recruited sixty Egyptian participants, 30 diabetic patients (type I or type II), and 30 healthy control subjects between October 2022 & May 2023. TCD and carotid duplex examinations were performed for all participants after obtaining an informed oral consent.
Results
Declared significant difference in the mean middle cerebral artery (MCA) Pulsatility index (PI) and Resistance index (RI) values in diabetics compared to control. The MCA pulsatility index (MCA-PI) was significantly higher in diabetic patients compared to control subjects, as was the MCA-RI. The PI & RI of the MCAs were significantly higher in type II diabetes compared to type I diabetes. Mean of PI and RI of both MCAs can significantly predict diabetes with cutoff point 0.75 and 0.5 respectively with sensitivity 80% and specificity 50% for both.
Conclusion
The MCA-PI & RI in TCD ultrasound is significantly correlated with diabetes. The results suggest that TCD could be a useful tool to assess cerebral hemodynamic changes in diabetic people.
Interactions Between the Great Wall and Geographical Environment: An Application of Monte Carlo Simulation in Ming Dynasty Yansui Defense District
Authors: Yuan Li , Li Zhaoyi , Wang Yizhen , Hao Zhiguo , Yu Chunlei 
Published: December 2024

Abstract

As a UNESCO World Heritage Site, the Great Wall's site selection strategy embodies a nuanced interplay of geographical environmental intelligence, reflecting the sophisticated spatial cognition of ancient Chinese military engineering. To comprehensively understand the heritage-geographical environment interaction mechanisms, this study integrates Monte Carlo simulation, spatial density analysis, kernel density estimation, and partial correlation analysis into a novel ‘Geographical Factor-Oriented Cognitive Framework for Great Wall Site Selection’. The framework deconstructs the intrinsic relationship between the Great Wall and its natural environment across three critical dimensions: spatial representation, environmental preferences, and defensive features. By systematically analyzing the interaction between individual and composite geographical factors, the research offers an innovative scientific approach to interpreting the underlying spatial logic of heritage site selection. The proposed framework is employed in a case study of the Ming Dynasty Yansui Defense District. The quantitative results indicate that the Great Wall demonstrates a significant layout strategy that combines high-density frontline defense with deep strategic support. Depending on the geographical characteristics of the eastern, central, and western routes, the siting is influenced by specific geographical combination factors, showing distinct regional characteristics: the eastern route fully utilizes the geographical advantage of numerous river valleys, with elevation and hydrographic systems being the core influencing factors, showing significant partial correlation; the central route transitions from loess ridges to desert grasslands, where visibility becomes the primary consideration for constructing the defense system; for the western route, in the loess high plain area, the elevation increases sharply, and the number of watchtowers increases, with the partial correlation of elevation and slope significantly enhanced, reflecting adjustments in defense focus and strategy. Additionally, each heritage type exhibits differentiated adaptability to geographical factors based on its specific functional characteristics, further highlighting the critical interaction between heritage siting, topography, and military strategic needs. This research provides a scientific approach to understanding the wisdom behind the Great Wall’s site selection.
Unveiling the Molecular Mechanisms of γ-polyglutamic acid-Mediated Drought Tolerance in Cotton through Transcriptomic and Physiological Analyses
Authors: Wang Ziyu , Zhang Xin , Liusui Yunhao , Fu Wanwan , Han AiXia , Zhao Dongmei , Yue Jisheng , Tu Yongfeng , Zhang Jingbo , Guo Yanjun 
Published: December 2024

Abstract

Background
Drought severely impacts the growth of cotton, and the application of plant biostimulants offers an effective approach to enhancing crop drought tolerance. γ-Poly-glutamic acid (γ-PGA) is a novel and environmentally friendly biostimulant, but its functions and mechanisms in responding to drought stress in cotton are still unclear.
Results
This study aims to elucidate the role of the plant biostimulant γ-PGA in the response of cotton to drought stress. Cotton seedlings treated with exogenous γ-PGA and a control group were subjected to drought conditions, and phenotypic observations along with measurements of relevant physiological indicators were conducted. The results showed that the activities of superoxide dismutase (SOD) and peroxidase (POD), as well as the proline (PRO) content in the leaves of γ-PGA-treated cotton, were higher than those in the control group, while malondialdehyde (MDA) content was lower. This indicates that exogenous application of γ-PGA can effectively enhance cotton's tolerance to drought stress. Subsequently, transcriptome sequencing was performed on the leaves of cotton plants under drought stress in both the γ-PGA-treated and control groups. The results revealed that γ-PGA treatment led to the upregulation of 1,658 genes and the downregulation of 589 genes. Among these differentially expressed genes (DEGs), 233 were transcription factors, suggesting that γ-PGA participates in the cotton drought stress response by regulating the expression of numerous transcription factors. Most of the DEGs were associated with the plant hormone signal transduction pathways and the MAPK signaling pathway, indicating that γ-PGA enhances cotton's drought tolerance primarily by regulating these two signaling pathways.
Conclusions
This study elucidates the effects of exogenous γ-PGA on drought resistance in cotton, as well as the molecular mechanisms underlying this resistance. The findings provide a theoretical foundation for the future application of γ-PGA to enhance drought tolerance in cotton.
Network of Cognitive, Emotional, and Pain Perception Factors Linked to Non-Suicidal Self-Injury Thoughts and Behaviors in Chinese Adolescents
Authors: Luo Wei , Gong Jingbo , Zhou Han-yu , Guo Juanjuan , Xiao Jieyu , Yan Chao , Chen Yuqi 
Published: December 2024

Abstract

Background
The cognitive-emotional model posits that negative self-concepts and maladaptive emotional regulation are key factors contributing to Non-Suicidal Self-Injury (NSSI). However, the interplay between pain perception, pain management, and these cognitive and emotional factors in the context of NSSI remains unclear. In this study, we employed a network approach to investigate the network structures of these factors related to NSSI thoughts and behaviors among Chinese adolescents. Additionally, we examined how depressive symptoms might moderate these associations.
Methods
A sample of 2756 adolescents validly completed self-report questionnaires about their emotional experiences, self-cognition, pain perception, depression level and frequency of NSSI. Network analyses were used to examine the interrelationship between NSSI, emotional experiences, self-cognition and pain perception. A network comparison test was further conducted between Non-depression proneness (Non-DP) group and depression proneness (DP) group.
Results
Among the cognitive-emotional-pain factors network, cognitive (i.e., early maladaptive schemas), pain perception (i.e., tolerance for mental pain) as well as NSSI thoughts were the main factors most strongly associated with NSSI behavior. A network comparison test showed that, compared to the Non-DP group, the DP group exhibited a negative association between pain endurance and NSSI thoughts, additionally, NSSI thoughts had higher centrality in the DP group’s network.
Conclusions
Our study highlighted the significant roles of cognitive and pain perception factors in adolescent NSSI behavior, supporting the cognitive-emotional-pain theoretical hypothesis. Additionally, these findings underscore the importance of mental pain tolerance and NSSI thoughts in understanding NSSI in depressed adolescents, offering new perspectives for prevention strategies.
PERFUSE - A Real-World Study on Rheumatology Patients’ Persistence with Adalimumab Biosimilar SB5 in France: Impacts of Patient Experience
Authors: Fautrel Bruno , Salliot Carine , Bernardeau Christophe , Maugars Yves , Coury Fabienne , Tropé Sonia , Lafarge Delphine , Camoin Armelle , Addison Janet 
Published: December 2024

Aim
This study aimed to provide new insights into patient training and satisfaction using Patient-reported Outcome Measures (PROMs) and their impact on 12-month persistence using SB5 in France.

Background
SB5 is an EMA-approved adalimumab biosimilar, demonstrating bioequivalence, equivalent efficacy, and similar safety and immunogenicity as the reference biologic.

Objective
The purpose of this study was to assess the effect of training practices on SB5 use in rheumatology and patient satisfaction, and measure their impact on 12-month persistence of SB5 use in real life in France.

Methods
508 eligible patients diagnosed with rheumatoid arthritis (n=117), psoriatic arthritis (n=78), or ankylosing spondylitis (n=313) were included in the observational PERFUSE study between October 2018 and December 2020 at 25 clinical sites across France. PROMs were collected 1-month after baseline via an online questionnaire designed with patient associations’ input. Persistence of SB5 use was captured during routine visits. The study (clinical trial NCT03662919) received regulatory approval from French authorities on March 21, 2018.

Results
Training on the correct use of SB5 injections was accepted (naive = 92.4%; pretreated = 82.6%) and appreciated (naive = 95.9%; pretreated = 97.4%) by patients. Satisfaction scores were high for all subgroups. Higher satisfaction with the injection device was linked to a lower probability of discontinuing treatment [HR=0.87; 95% CI (0.79; 0.96); p<0.05], as was a worse perception of the illness assessed using the B-IPQ [HR=1.03; (1.00; 1.05); p<0.05]. Moreover, a significantly higher proportion of ePRO (electronic Patient-reported Outcomes) respondents (n=221/508) remained on SB5 at 12 months than non-respondents [66.4% (59.3; 72.5) vs. 48.7% (42.4; 54.8); p<0.05].

Conclusion
Lower initial satisfaction may serve as a useful indicator for identifying individuals at a higher risk of non-persistence. This could provide a basis for recommending the standardization of patient information practices throughout France, particularly for pretreated patients.
Predictors of Adolescents’ Subjective Happiness Based on Roy’s Adaptation Model: A Longitudinal Study
Authors: Yang Jeong-Eun , Moon SeolHwa 
Published: December 2024

Introduction/Objective
Improving subjective happiness is significant since it is a measure of positive development and has been linked to health benefits during adolescence.. The purpose of this study was to investigate factors associated with longitudinal changes in subjective happiness among Korean adolescents based on Roy’s adaptation theory.

Methods
This secondary data analysis study used longitudinal data from 2018 and 2021 from the Korea Welfare Panel Study. This study examines the major stimuli and environmental factors influencing adolescents, categorized as focal and contextual stimuli. Cognitive and emotional strategies, conceptualized as the cognator, are measured through depression, anxiety, withdrawal, and aggression. External adaptive responses, including self-concept and role function, are evaluated for their effects on subjective happiness. To identify the factors associated with subjective happiness, hierarchical multiple linear regression was conducted, with focal stimuli and contextual stimuli included in the first step, cognator in the second, and self-concept and role function in the third, respectively.

Results
The mean age of 324 adolescents was 13.94 (SD±0.80) years, and the subjective happiness scores were 25.10 (SD±4.00) and 19.56 (SD±3.49) at baseline and after three years, respectively. Neglect in focal stimuli (β =-0.11, 95% CI: -0.96, -0.02), academic environment in contextual stimuli (β =0.15, 95% CI: 0.04, 0.39), depression & anxiety in cognator (β =-0.20, 95% CI: -0.29, -0.04), and peer attachments (β =0.19, 95% CI: 0.11, 0.45) in role function explained 14.5% of the variance in subjective happiness.

Conclusion
After a 3-year longitudinal observation, adolescents' subjective happiness decreased, with neglect and academic environment as key stimuli, depression and anxiety as cognitive responses, and peer attachments as role functions. These results emphasized the need for interventions to enhance emotional support, prevent neglect, manage academic stress, and improve peer relationships. Furthermore, approaches should prioritize comprehensive interventions and long-term follow-up to improve adolescent mental health.
Pesticide Exposure and Cancer Risk: A Cross-Sectional Study on Farmers in Nakhon Sawan, Thailand
Authors: Vatthanasak Adisorn , Juntarawijit Chudchawal , Jampachaisri Katechan , Sarin Charoon 
Published: December 2024

Introduction
Cancer is a leading cause of disease burden worldwide. Although much of the existing literature, primarily from Western countries, suggests an association between pesticide exposure and cancer risk, these findings may not be directly applicable to the Thai population. This is due to differences in social, economic, and public health contexts, as well as variations in health status, pesticide use patterns, and self-protection behaviors. This study aimed to investigate the relationship between pesticide exposure and cancer risk among Thai farmers. The findings are expected to contribute valuable insights for public health prevention and control programs, as well as enhance the existing body of literature.

Methods
In this cross-sectional study, data were collected from 10,646 farmers aged 20 years and older through in-person interviews using a structured questionnaire. The association between pesticide exposure and cancer was analyzed using logistic regression, adjusting for potential confounding factors.

Results
The study identified a significant association between the historical use of pesticides, including insecticides, herbicides, and fungicides, and cancer risk. Among 39 individual pesticides examined, sixteen were found to have a significant odds ratio. The study’s results aligned with existing literature regarding the potential effects of glyphosate, paraquat, 2,4-D, folidol, chlorpyrifos, EPN, mevinphos, dichlorvos, endosulfan, dieldrin, mancozeb, maneb, and copper sulfate. Additionally, this study newly identified a significant association with propineb (OR = 2.41, 95% CI: 1.39–4.17), carbendazim (OR = 1.77, 95% CI: 1.11–2.81), and benomyl (OR = 4.04, 95% CI: 1.69–9.63).

Conclusion
The study found cancer prevalence among farmers in Nakhon Sawan, Thailand, to be associated with historical pesticide use. These findings aligned with existing literature, underscoring the potential effects of long-term pesticide exposure on cancer risk. This issue warrants increased public attention and stricter regulation of pesticide use. An effective exposure prevention program should be urgently implemented, particularly for Thai farmers.
SEISMIC RATE CHANGES ANALYSIS BASED ON THE SPASIAL DISTRIBUTION SEISMOTECTONICS IN THE SOUTHERN SUMATRA REGION
Authors: Florentina Simalango Nora , Syafriani Syafriani , Dwiridal Letmi , Zulhendra Zulhendra 
Published: December 2024

The southern Sumatra region experiences high seismic activity, often resulting in large earthquakes that cause significant losses. Before such earthquakes, a phenomenon known as seismic quiescence a decrease in seismic activity commonly occurs. This phenomenon can be analyzed through changes in seismic rates using the spatial distribution of Z-values. This study investigates the occurrence of seismic quiescence before major earthquakes and examines changes in seismic rates in southern Sumatra. Used secondary earthquake data from the United States Geological Survey (USGS) for 1973–2023 were analyzed, focusing on the region between 2.050°S–5.885°S and 101.030°E–106.611°E. The study centered on three significant earthquakes: the 2000 (7.9 Mw), 2001 (7.4 Mw), and 2007 (8.4 Mw) events. Seismic rate changes were analyzed using the Z-value method, dividing the region into grids to calculate and spatially distribute Z-values. Results showed seismic quiescence before the 2000 (±16 years), 2001 (±13 years), and 2007 (±17 years) earthquakes in Bengkulu. Additionally, similar phenomena were observed in Bengkulu and Lampung before 2023, suggesting the potential for future significant earthquakes in the region. These findings highlight seismic quiescence as a precursor to major seismic events.
Asentamientos informales: mejorar el hábitat, desestimar la vivienda
Authors: Brizuela Florencia 
Published: December 2024

Desde la década de 1990 diversos municipios de América Latina desarrollaron programas orientados a mejorar el hábitat de los asentamientos informales con acciones de infraestructura, equipamiento urbano, fortalecimiento de la comunidad y rehabilitación del espacio público. En general, estos programas sostuvieron que no intervendrían en la mejora de la vivienda, bajo el supuesto de que esa era una tarea que correspondía a la esfera privada. Como corolario, las condiciones estructurales de la vivienda quedaron libradas a las acciones individuales de cada familia. En este marco, el artículo se propuso analizar la problematización que sugirió mejorar el hábitat de los asentamientos informales y descartó mejorar la vivienda en esos espacios. Situado en el enfoque de historia del presente el trabajo reconstruyó los saberes y debates expertos que posibilitaron dicha problematización en torno a la Conferencia de Estocolmo de 1972 y la Conferencia de Naciones Unidas sobre los Asentamientos Humanos de 1976
Family Business Succession: Analysis of Success Drivers Based on Entrepreneurship Theory using NVivo modeling
Authors: Pradeliana Dewa Satrio , Margaretha Yolla 
Published: December 2024

This study explores the influence of personal and organizational characteristics on the motivation of successors in family business succession in Indonesia. Through a survey involving 30 respondents from West Java, data were analyzed using NVivo software. Findings indicate that age, gender, and business scale influence successor motivation, especially when succession plans are in place. The research highlights the importance of mature succession planning as a key to family business success. These findings can support the development of more effective policies and improvements in succession process management. Limitations of the study include questions that do not consider the business sector comprehensively and the need for a more varied sample. Future research can enrich this model and address these limitations to deepen understanding of family business succession.
Keyword: family business succession, personal characteristics, organizational characteristics, motivation
The Complexity of Communication in the Sustainable Utilization of Coconut Waste for Local Economic Development
Authors: Kamil Indriyati , Rosimah Siti , Rohmana  , Sari Nur Zeina Maya 
Published: December 2024

Objective: This research analyzes effective communication strategies to optimize the sustainable utilization of coconut waste, aiming to support local economic development through enhanced collaboration among industry, government, and the community.

Theoretical Framework: Using a stakeholder theory approach, this study identifies the challenges and communication dynamics among various parties, focusing on differences in interests, goals, and perspectives that influence collaboration. Effective communication strategies, such as open dialogue, trust-building, and the use of communication platforms that facilitate active participation, are essential to address these complexities.

Method: A qualitative research method was used to understand communication in the context of local economic empowerment in Panyileukan District, Bandung City, West Java. Informants were selected through purposive sampling, including coconut traders, private sector representatives, government officials, environmental community members, volunteers, and local residents. Data were collected through observation, in-depth interviews, and focus group discussions, and analyzed using stakeholder analysis to identify roles, interests, and interactions among stakeholders.

Results and Discussion: The findings show that stakeholder diversity and communication challenges, such as miscommunication and differences in understanding, can be overcome through communication strategies that involve open dialogue and active participation.

Research Implications: This research provides important insights into the relationship between effective communication and the success of local economic empowerment through the utilization of coconut waste.

Originality/Value: This study offers new strategies with the potential to enhance collaboration and contributes to the literature on environmental communication and sustainable economic development.