bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing Tropical Cyclone Structures during Secondary Eyewall Formation Using Aircraft In Situ Observations
Authors: Wunsch Katharine E. D. , Didlake Anthony C. 
Published: September 2018

Abstract
The dynamical mechanisms for secondary eyewall formation (SEF) in tropical cyclones (TCs) are not yet fully understood. Most hypotheses for SEF rely on the early presence of persistent and widespread rainband convection outside of the primary eyewall. This convection eventually coalesces into a secondary eyewall through both axisymmetric and asymmetric processes, but the extent and importance of these dynamical processes and their associated convective structures remain unclear. This study examines the evolution of axisymmetric and asymmetric structures in a composite analysis of Atlantic TCs from 1999 to 2015 using aircraft reconnaissance observations from the Extended Flight-Level Dataset for Tropical Cyclones (FLIGHT+). Compared to intensifying TCs that did not experience SEF, TCs undergoing SEF showed axisymmetric broadening of the outer wind field in the tangential wind and angular momentum profiles before SEF. Thermodynamic observations indicated features consistent with strengthening eyewall convection. We also analyzed TCs in shear-relative quadrants to examine the evolution of asymmetric kinematic and thermodynamic structures during SEF. Utilizing a new normalization technique based on the radii of both eyewalls, we isolated the structures surrounding the secondary eyewall before and during SEF. Using this technique, we found that kinematic structures of the developing secondary eyewall were most prominent in the left-of-shear half, and the thermodynamic structures of the secondary eyewall became more axisymmetric during SEF. Asymmetries developed in the primary eyewall thermodynamics as it decayed. Understanding the evolution of these observed structures characteristic to SEF will improve our ability to predict SEF and the resulting changes in TC intensity and structure.
Interstate Distribution and Sectoral Composition of FDI Inflows in India
Authors: K. Febina , Kattookaran Thomas Paul 
Published: September 2018

Foreign direct investment (FDI) refers to obtaining the ownership in a foreign business entity. It can also be attributed that FDI circulates capital across national boundaries. It can be defined as an investor based in one country (home country), acquires an asset in another country (host country), with the intention to manage it. It is this dimension of management that distinguishes FDI from portfolio investment in foreign stocks and other financial instruments. For a terribly populated country like India, a good quantum of resource is needed to fund its various developmental needs, which the country does not have. To strengthen its infrastructure, expertise and knowledge base, FDI is inevitable. Realizing these facts, the government is now moulding a robust business environment to smoothen the flow of FDI. An interstate comparison of FDI in India makes it quite apparent that there exists huge variations in the inflow of FDI to different states. While some regions like Delhi, Bombay, etc. receive soaring flow of FDI, it is very stumpy in regions like Patna, Guwahati, etc. An overview on the sectoral distribution of foreign investment discloses the wide disparity in the distribution of foreign capital among various sectors. While some sectors like service, construction, etc. receive elevated flow of foreign capital, others lie fully ignored by the foreign investors. JEL Classification: F21, F23, F63, O10
Understanding the ideology of the Swedish tax-paid school meal
Authors: Persson Osowski Christine , Fjellström Christina 
Published: September 2018

Background: Children are provided with food at school in various ways. In Sweden, free school lunches are provided to all children of compulsory school age. Internationally, Sweden is fairly unique in this sense, which makes the country an important example to study and reflect upon. Objective: This article aims to describe the welfare ideology that underpins the provision of school meals in Sweden. Setting: Schools in Sweden. Method: The ideological underpinnings of the free school lunches provided in Sweden are described using the Seven Elements of Public Meals framework, which comprises the elements of welfare, health, sustainability, learning, social environment, physical environment and food. Results: Our findings suggest that school meal provision in Sweden is seen as a universal welfare service and a part of public health work. Meals are to be sustainable and are regarded as a learning occasion. The importance of the social and physical environment is accentuated, and when it comes to the quality of the food served, the school meal has improved over the years. Conclusion: The choice of food in schools is increasingly expected to be guided by personal choice. However, the privilege of being served a shared free school meal comes at the cost of less individual choice.
Behavioral Adaptations to Lane Keeping Systems: Effects of Exposure and Withdrawal
Authors: Miller Erika E. , Boyle Linda Ng 
Published: September 2018

Objective: A driving simulator study was conducted to evaluate the longitudinal effects of an intervention and withdrawal of a lane keeping system on driving performance and cognitive workload. Background: Autonomous vehicle systems are being implemented into the vehicle fleet. However, limited research exists in understanding the carryover effects of long-term exposure. Methods: Forty-eight participants (30 treatment, 18 control) completed eight drives across three separate days in a driving simulator. The treatment group had an intervention and withdrawal of a lane keeping system. Changes in driving performance (standard deviation of lateral position [SDLP] and mean time to collision [TTC]) and cognitive workload (response time and miss rate to a detection response task) were modeled using mixed effects linear and negative binomial regression. Results: Drivers exposed to the lane keeping system had an increase in SDLP after the system was withdrawn relative to their baseline. Drivers with lane keeping had decreased mean TTC during and after system withdrawal compared with manual drivers. There was an increase in cognitive workload when the lane keeping system was withdrawn relative to when the system was engaged. Conclusion: Behavioral adaptations in driving performance and cognitive workload were present during automation and persisted after the automation was withdrawn. Application: The findings of this research emphasize the importance to consider the effects of skill atrophy and misplaced trust due to semi-autonomous vehicle systems. Designers and policymakers can utilize this for system alerts and training.
Institutional Completeness and Crime Rates in Immigrant Neighborhoods
Authors: Kubrin Charis E. , Kim Young-An , Hipp John R. 
Published: September 2018

Objectives: A growing body of research finds that immigration has a null or negative association with neighborhood crime rates. We build on this important literature by investigating the extent to which one theory, institutional completeness theory, may help explain lower crime rates in immigrant communities across the Southern California region. Specifically, we test whether two key measures of institutional completeness—the presence of immigrant/ethnic voluntary organizations in the community and the presence and diversity of immigrant/ethnic businesses in the community—account for lower crime rates in some immigrant communities. Method: Compiling a tract-level data set utilizing various data sources, we estimate negative binomial regression models predicting violent and property crime levels that include measures of institutional completeness while controlling for a range of neighborhood correlates of crime. We also account for possible endogeneity by estimating instrumental variable models. Results: The results reveal very limited support for institutional completeness theory. Conclusions: Several possible explanations for these findings are discussed.
Invasive Fungal Disease in Critically Ill Patients at High Risk: Usefulness of Lymphocyte Subtyping
Authors: Zhang Jiahui , Cui Na , Wang Hao , Han Wen , Li Yuanfei , Xiao Meng , Liu Dawei 
Published: September 2018

Objectives: This study aimed to investigate the distinguishing ability of lymphocyte subtyping for diagnosis and prognosis of invasive fungal disease (IFD). Methods: We assessed lymphocyte subtyping and evaluated the quantitative changes in key immunological parameters at intensive care unit (ICU) admission in critically ill patients at high risk and their potential influence on diagnosis and outcome of IFD. The primary outcome was 28-day mortality. Results: Among the 124 critically ill patients with mean Candida score 3.89 (0.76), 19 (15.3%) were in the IFD group. CD28+CD8+ T-cell counts (area under the curve [AUC] 0.899, 95% confidence interval [CI], 0.834-0.964, P < .001) had better distinguishing ability than other immune parameters for IFD diagnosis. The cutoff value of CD28+CD8+ T-cell counts at ICU admission for IFD diagnosis was 59.5 cells/mm3, with 83.3% sensitivity and 86.4% specificity. Multivariate logistic regression analysis identified CD28+CD8+ T-cell count <59.5 cells/mm3 (odds ratio 59.7, 95% CI, 7.33-486.9, P < .001) as an independent predictor for IFD diagnosis. CD28+CD8+ T-cell counts could also predict 28-day mortality (AUC 0.656, 95% CI, 0.525-0.788, P = .045). Kaplan-Meier survival analysis provided evidence that natural killer cell count <76.0 cells/mm3 (log-rank test; P = .001), CD8+ T-cell count <321.5 cells/mm3 (log-rank test; P = .04), and CD28+CD8+ T-cell count <129.0 cells/mm3 (log-rank test; P = .02) at ICU admission were associated with lower survival probabilities. Conclusion: CD28+CD8+ T-cell counts play an important role in early diagnosis of IFD. Low counts are associated with early mortality in critically ill patients at high risk of IFD. Our findings add evidence to the utility of lymphocyte subtyping in a diagnostic algorithm to better define IFD in critically ill patients at high risk.
Parents’ use of mobile computing devices, caregiving and the social and emotional development of children: a systematic review of the evidence
Authors: Beamish Nicola , Fisher Jane , Rowe Heather 
Published: September 2018

Objectives: Mobile device use is a rapidly growing, socially acceptable interactional habit. The impact of mobile device use on social interactions, including between parents and young children, is uncertain. The aim was to describe, synthesise and evaluate the evidence about parents’ mobile device use, caregiving and children’s social and emotional development. Methods: Seven medical and social sciences databases were searched using keywords and subject headings. Screening for eligibility used PRISMA guidelines and scientific and reporting quality were assessed with standardised checklists. Results: Eight studies met the inclusion criteria (four surveys, three qualitative and one mixed-method investigation). This small group of studies is of diverse quality, but there is evidence of associations between parents’ mobile device use, attention to caregiving and changes in child behaviour. Use of mobile devices during parenting activities may be infrequent and brief, but it can be a potent distraction that reduces caregiver responsiveness to children. Conclusions: An emerging body of research suggests mobile devices are associated with altered attention and responsivity to children by their caregivers and may change caregiver/child interactions. The evidence precludes questions about causality or discussion of impacts on child development. Knowledge gaps have been identified and they require future targeted research.
Advancing social and emotional well-being in Aboriginal and Torres Strait Islander Australians: Clinicians’ reflections
Authors: Balaratnasingam Sivasankaran , Chapman Murray , Chong Derek , Hunter Ernest , Lee Jason , Little Carolyn , Mulholland Kim , Parker Robert , Watson Marshall , Janca Aleksandar 
Published: September 2018

Objective: An expert reference group met on four occasions to consider ways forward in terms of Indigenous mental health. This paper summarises the discussion and recommendations. Conclusion: While the negative effects of colonisation and trans-generational trauma continue, we propose renewed emphasis on improving access, cultural orientation and trauma-informed care, and a focus on the needs of young Indigenous Australians.
Silent lesions on MRI imaging – Shifting goal posts for treatment decisions in multiple sclerosis
Authors: Min Myintzu , Spelman Tim , Lugaresi Alessandra , Boz Cavit , Spitaleri Daniele LA , Pucci Eugenio , Grand’Maison Francois , Granella Franco , Izquierdo Guillermo , Butzkueven Helmut , Sanchez-Menoyo Jose Luis , Barnett Michael , Girard Marc , Trojano Maria , Grammond Pierre , Duquette Pierre , Sola Patrizia , Alroughani Raed , Hupperts Raymond , Vucic Steve , Kalincik Tomas , Van pesch Vincent , Lechner-Scott Jeannette 
Published: September 2018

Background: The current best practice suggests yearly magnetic resonance imaging (MRI) to monitor treatment response in multiple sclerosis (MS) patients. Objective: To evaluate the current practice of clinicians changing MS treatment based on subclinical new MRI lesions alone. Methods: Using MSBase, an international MS patient registry with MRI data, we analysed the probability of treatment change among patients with clinically silent new MRI lesions. Results: A total of 8311 MRI brain scans of 4232 patients were identified. Around 26.9% (336/1247) MRIs with one new T2 lesion were followed by disease-modifying therapy (DMT) change, increasing to 50.2% (129/257) with six new T2 lesions. DMT change was twice as likely with new T1 contrast enhancing compared to new T2 lesions odds ratio (OR): 2.43, 95% confidence interval (CI): 2.00–2.96 vs OR: 1.26 (95% CI: 1.22–1.29). DMT change with new MRI lesions occurred most frequently with ‘injectable’ DMTs. The probability of switching therapy was greater only after high-efficacy therapies became available in 2007 (after, OR: 1.43, 95% CI: 1.28–1.59 vs before, OR: 0.98, 95% CI: 0.520–1.88). Conclusion: MS clinicians rely increasingly on MRI alone in their treatment decisions, utilizing low thresholds (1 new T2 lesion) for optimizing MS therapy. This signals a shift towards no evidence of disease activity (NEDA)-3 since high-efficacy therapies became available.
Optimizing contrast-enhanced cone-beam CT protocol to facilitate simultaneous visualization of neurovascular pathologies and surrounding structures of interest
Authors: Duckworth Edward AM , Chintalapani Gouthami , Camstra Kevin M , Kan Peter 
Published: September 2018

Objective Contrast-enhanced cone-beam computed tomography (CBCT) imaging is commonly used for evaluating neurovascular stents and their relationship to the parent artery or vascular pathologies such as arteriovenous malformations (AVMs) and dural arteriovenous fistulas (dAVFs) in the context of surrounding anatomical structures. The purpose of this study was to understand the effects of varying concentrations of contrast medium used in CBCT imaging for optimal visualization of various endovascular devices and anatomical pathologies. Methods Thirty-five patients with various neurovascular pathologies were included in the study. Contrast-enhanced CBCT images (20 s DR, Siemens syngo DynaCT, Siemens AG, Forchheim, Germany) were acquired in all cases, with varying dilutions of contrast medium, from 1% to 30%. The injection rate was kept constant at 3 cc/sec with an X-ray delay of two sec, and a total volume of 66 cc of diluted contrast was administered. Results from visual and quantitative analysis were reported. Results Ten percent dilution of contrast medium resulted in the best image differentiation between flow-diverter devices and the parent artery. Concentrations as low as 2.5% contrast medium also resulted in identifying AVMs in the context of the surrounding brain parenchyma, whereas 20% to 30% dilution provided the best visualization of residual AVMs with prior Onyx embolization and dAVFs in the presence of bony structures. Conclusions Simultaneous visualization of brain parenchyma, bony structures, devices, and pathological anatomy using contrast-enhanced CBCT imaging is feasible with appropriate doses of iodinated contrast, and should be tailored to the individual case based on the goals of CBCT.
Lessons learned and new directions regarding Discharge Direct from Adult Intensive Care Units Sent Home (DISH): A narrative review
Authors: Basmaji John , Lau Vincent , Lam Joyce , Priestap Fran , Ball Ian M 
Published: September 2018

Purpose To perform a narrative review of the literature regarding the discharge of patients directly to home (DDH) from the intensive care unit, and to identify patient characteristics and clinical outcomes associated with this practice. Methods We searched MEDLINE and EMBASE from 1946 to present. We also manually searched the references of relevant articles. A two-step review process with three independent reviewers was used to identify relevant articles based on predetermined inclusion/exclusion criteria. Results Four studies were included in the final review. Two studies were retrospective and two studies were prospective that shared data from the same patient cohort. All were single center studies. Two of the four studies outlined clinical outcomes associated with DDH. Conclusions This study highlights the relative dearth in the literature regarding the increasingly common practice of DDH, underscores the importance of further studies in this area, and identifies future important foci of research.
Evaluation of the Use of Exenatide Once-Weekly Suspension Autoinjector Among Patients With Type 2 Diabetes Mellitus and Health Care Professionals
Authors: LaRue Susan , Springer Jane , Noderer Michael , Meehan James , Wysham Carol H. 
Published: September 2018

Background: Ease of injection is important to patients. An autoinjector was developed to deliver exenatide, a glucagon-like peptide-1 receptor agonist for type 2 diabetes mellitus. For autoinjection, 0.06-mm exenatide-containing microspheres are suspended in medium-chain triglycerides. Herein, we report design verification and usability testing of the autoinjector for exenatide once-weekly suspension (QWS) delivery. Methods: Exenatide QWS in a single-chamber cartridge is self-injected subcutaneously with three main steps: mix, unlock, and inject. Design verification testing used validated testing methodology. A summative validation study with simulated-use scenarios evaluated unassisted performance on critical tasks (ease of use and the injection process). Results: The autoinjector met specified design requirements for dose accuracy and torque/force. Of 104 participants enrolled (73 lay users, 16 health care professionals, and 15 pharmacists), 90 independently referred to instructions for use during testing. Users successfully achieved critical tasks on first attempt 87-100% of the time. Approximately 78% of participants successfully completed the full injection scenario, including 72% of lay users reporting visual or dexterity impairments. Initial use errors on critical tasks included not mixing well (n = 12), not removing needle cap (n = 8), and not holding needle to the skin for complete injection (n = 5). Untrained injection-naïve and trained injection-experienced lay users made the fewest errors (7% and 3%, respectively). Trained and untrained participants took 2:33 and 5:03 minutes, respectively, to complete a weekly injection. Conclusions: Users with a range of injection experience can rapidly learn to administer exenatide QWS autoinjector correctly, thus minimizing patient effort to manage their diabetes with injectable therapy.
MRI of lobar holoprosencephaly in a cat with hypodipsic hypernatraemia
Authors: Shimbo Genya , Tagawa Michihito , Yanagawa Masashi , Miyahara Kazuro 
Published: September 2018

Case summary A 2-year-old neutered female domestic shorthair cat presented with a history of hypodipsia, recurrent hypernatraemia, pelvic limb ataxia and tremor. The serum arginine vasopressin level was low for the serum osmolality. MRI of the brain revealed a failure of separation of the cerebrum, which manifested as absence of the rostral part of the corpus callosum, fornix and septum pellucidum, thus resulting in a single fused ventricle. The diagnosis was lobar holoprosencephaly with hypodipsic hypernatraemia. Relevance and novel information To our knowledge, this is the first description of the MRI characteristics of lobar holoprosencephaly in a cat. This report suggests that MRI examination should be considered for precise diagnosis of hypodipsic hypernatraemia in young cats.
Patient Characteristics and Predictors of Return to Sport at 12 Months After Anterior Cruciate Ligament Reconstruction: The Importance of Patient Age and Postoperative Rehabilitation
Authors: Edwards Peter K. , Ebert Jay R. , Joss Brendan , Ackland Timothy , Annear Peter , Buelow Jens-Ulrich , Hewitt Ben 
Published: September 2018

Background: Preventing and mitigating the risk of reinjury after anterior cruciate ligament reconstruction (ACLR) rest on variables including age, surgical restoration of knee stability, adequate physical function, and thorough and complete postoperative rehabilitation, but to what degree these factors influence return to sport is unclear. Purpose: To investigate factors predictive of return to sport 12 months after ACLR. The factors specifically evaluated were strength, hop function, self-reported knee function, patient age, and quality of postoperative rehabilitation. Study Design: Case-control study; Level of evidence, 3. Methods: This study evaluated 113 patients approximately 12 months after ACLR using a rehabilitation grading tool, the subjective International Knee Documentation Committee (IKDC) form, and a return-to-sport battery consisting of maximal isokinetic quadriceps and hamstring strength and 4 functional hop tests. Mann-Whitney U tests and chi-square analyses were used to determine differences between patients who had or had not returned to sport. A subsequent binary logistic hierarchical regression determined the factors predictive of a patient’s return to sport. In those patients who had returned to sport, relationships between either age or level of rehabilitation and passing the return-to-sport battery were also investigated. Results: Complete rehabilitation (adjusted odds ratio [OR], 7.95; P = .009), age ≤25 years (adjusted OR, 3.84; P = .024), and higher IKDC scores ( P < .001) were predictive of return to sport at 12 months. In participants who had returned to sport, 21% passed the return-to-sport battery compared with only 5% who did not. Of those who had returned to sport, 37% who underwent complete rehabilitation passed the return-to-sport battery as opposed to 5% who underwent incomplete rehabilitation. In patients aged ≤25 years, only 48% underwent complete rehabilitation, despite having returned to sport. Additionally, in this group of patients, 40% underwent complete rehabilitation and passed the physical performance battery as opposed to only 4% who did not undergo complete rehabilitation. Conclusion: Younger patients and higher subjective IKDC scores were predictive of return to sport. Patients who completed 6 months of rehabilitation incorporating jumping and agility tasks had a higher rate of return to sport, suggesting that postoperative rehabilitation is important in predicting return to sport. Specialists and physical therapists alike should stress the importance of thorough postoperative rehabilitation and adequate neuromuscular strength and function to patients whose goals are to return to sport.