bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research and Application of In‐seam Seismic Survey Technology for Disaster‐causing Potential Geology Anomalous Body in Coal Seam
Authors: TENG Jiwen , LI Songying , JIA Mingkui , LIAN Jie , LIU Honglei , LIU Guodong , WANG Wei , Volker SCHÄPE , FENG Lei , YAO Xiaoshuai , WANG Kang , YAN Yafen , ZHANG Wanpeng 
Published: October 2019

AbstractIn order to effectively detect potential geology anomalous bodies in coal bearing formation, such as coal seam thickness variation, small faults, goafs and collapse columns, and provide scientific guidance for safe and efficient mining, the SUMMIT‐II EX explosion‐proof seismic slot wave instrument, produced by German DMT Company, was used to detect the underground channel wave with the help of transmission method, reflection method and transflective method. Region area detection experiment in mining face had been carried out thanks to the advantage of channel wave, such as its great dispersion, abundant geology information, strong anti‐interference ability and long‐distance detecting. The experimental results showed that: (1) Coal seam thickness variation in extremely unstable coal seam has been quantitatively interpreted with an accuracy of more than 80% generally; (2) The faults, goafs and collapse columns could be detected and predicted accurately; (3) Experimental detection of gas enrichment areas, stress concentration regions and water inrush risk zone has been collated; (4) A research system of disaster‐causing geology anomalous body detection by in‐seam seismic survey has been built, valuable and innovative achievements have been got. Series of innovation obtained for the first time in this study indicated that it was more effective to detect disaster‐causing potential geology anomalies by in‐seam seismic survey than by ground seismic survey. It had significant scientific value and application prospect under complex coal seam conditions.
The Early Permian Woniusi Flood Basalts from the Baoshan Terrane, SW China: Petrogenesis and Geodynamic Implications
Authors: CAO Jun , ZHANG Gaizhi , WANG Xuan , CHEN Jun 
Published: October 2019

AbstractThe Woniusi flood basalts from the Baoshan terrane, SW China, represent a significant eruption of volcanic rocks which were linked to the Late Paleozoic rifting of the Cimmeria from the northern margin of East Gondwana. However, the precise mechanism for the formation and propagation of the rifting is still in debate. Here we report 40Ar/39Ar dating, whole‐rock geochemistry, and Sr–Nd–Pb isotopes for the Woniusi basalts from the Baoshan terrane of SW China, with the aim of assessing if a mantle plume was related to the formation of the continent Cimmeria. 40Ar/39Ar dating of the Woniusi basalts yielded ages of 279.3 ± 1.1 Ma and 273.9 ± 1.5 Ma, indicating they were emplaced during the Early Permian. Whole‐rock geochemistry shows that these basalts have subalkaline tholeiitic affinity, low TiO2 (1.2–2.2 wt%), and fractionated chondrite‐normalized LREE and nearly flat HREE patterns [(La/Yb)N = 2.86–5.77; (Dy/Yb)N = 1.21–1.49] with noticeable negative Nb and Ta anomalies on the primitive mantle‐normalized trace element diagram. The ∊Nd(t) values (–4.76 to +0.92) and high (206Pb/204Pb)i (18.40–18.66) along with partial melt modeling indicates that the basalts were likely derived from a sub‐continental lithospheric mantle (SCLM) source metasomatized by subduction‐related processes. On the basis of a similar emplacement age to the Panjal basalts and Qiangtang mafic dykes and flood basalts in the Himalayas, combined with a tectonic reconstruction of Gondwana in the Early Permian, we propose that the large‐scale eruption of these basalts and dykes was related to an Early Permian mantle plume that possibly initiated the rifting on the northern margin of East Gondwana.
Prognostic significance of IMMT expression in surgically‐resected lung adenocarcinoma
Authors: Hiyoshi Yasuhiro , Sato Yuichi , Ichinoe Masaaki , Nagashio Ryo , Hagiuda Daisuke , Kobayashi Makoto , Kusuhara Seiichiro , Igawa Satoshi , Shiomi Kazu , Goshima Naoki , Murakumo Yoshiki , Saegusa Makoto , Satoh Yukitoshi , Masuda Noriyuki , Naoki Katsuhiko 
Published: October 2019

AbstractBackgroundMitochondrial dysfunction contributes to many types of human disorders and cancer progression. Inner membrane mitochondrial protein (IMMT) plays an important role in the maintenance of mitochondrial structure and function. The aims of this study were to examine IMMT expression in lung adenocarcinoma and evaluate its correlation with clinicopathological parameters and patient prognosis.MethodsIMMT expression was immunohistochemically studied in 176 consecutive lung adenocarcinoma resection tissues, and its correlations with clinicopathological parameters were evaluated. Kaplan‐Meier survival analysis and Cox‐proportional hazards models were used to estimate the effect of IMMT expression on survival.ResultsHigh‐IMMT expression was detected in 84 of 176 (47.7%) lung adenocarcinomas. Levels were significantly correlated with advanced disease stage (stage II and III; P = 0.024), larger tumor size (>3 cm; P = 0.002), intratumoral vascular invasion (P < 0.001), and poorer adenocarcinoma patient prognosis (P = 0.002). Based on 176 patients with adenocarcinoma, multivariate analysis revealed that IMMT expression was an independent predictor of poorer survival (HR, 1.99; 95% confidence interval [CI], 1.06–3.74; P = 0.031). Further, treating A549 cells derived from lung adenocarcinoma, with IMMT siRNA resulted in significantly decreased proliferation.ConclusionHere, we first demonstrated that high‐IMMT expression is related to some clinicopathological parameters, and that its expression is an independent prognostic predictor of poorer survival in patients with lung adenocarcinoma; further studies are required to clarify the biological function of IMMT in lung adenocarcinoma. However, results suggest that this protein could be a novel prognostic indicator and therapeutic target.
Neuroendocrine marker staining pattern categorization of small‐sized pulmonary large cell neuroendocrine carcinoma
Authors: Minami Kazuhiro , Tanaka Yugo , Ogawa Hiroyuki , Jimbo Naoe , Nishio Wataru , Yoshimura Masahiro , Itoh Tomoo , Maniwa Yoshimasa 
Published: October 2019

AbstractBackgroundThe aim of this study was to identify subgroups with good or bad prognosis in patients with pulmonary large cell neuroendocrine carcinoma (LCNEC) based on immunostaining patterns with neuroendocrine markers and compare them with small cell lung carcinoma (SCLC).MethodsFrom January 2001 to December 2017, of all patients with resected LCNEC and SCLC, we selected patients whose pathological tumor sizes were ≤30 mm in diameter (defined as small‐sized tumors) and who underwent complete resection with lymphadenectomy. We classified patients with small‐sized LCNEC (sLCNEC) into two subgroups based on immunostaining patterns with three neuroendocrine markers (chromogranin A, synaptophysin, and NCAM) and compared them to small‐sized SCLC (sSCLC).ResultsA total of 48 patients with sLCNEC and 39 patients with sSCLC were enrolled. Of 48 patients with sLCNEC, 21 were categorized as the small‐sized triple‐positive group (sTP), whose patients were positive for the three neuroendocrine markers, and 27 patients were categorized as the small‐sized nontriple‐positive group (sNTP), whose patients were not positive for all three neuroendocrine markers. The percentage of lymph node metastasis was significantly lower in sNTP than in sTP and sSCLC. There was no significant difference in overall survival, but recurrence‐free survival (RFS) and tumor‐specific survival (TSS) were significantly poorer in sTP and sSCLC than in sNTP. Multivariate analysis revealed sTP and sSCLC were independent prognostic factors for poorer RFS and TSS than those of sNTP.ConclusionsThe sNTP subgroup had a good prognosis and the sTP subgroup a poor prognosis. There were some similarities in clinicopathological features between sTP and sSCLC.
New Neolithic sites in the western al‐Hajar mountains
Authors: Białowarczuk Marcin , Szymczak Agnieszka 
Published: October 2019

AbstractA new archaeological project in the western al‐Hajar Mountains in northern Oman involves a systematic survey of the small valley of Qumayrah and excavation of selected sites. Two field seasons revealed a number of Neolithic settlement traces. Three newly discovered sites were excavated, two of which proved to be stratified. The most intensive fieldwork focused on QA 2, a Stone Age campsite that contained stone structures, numerous lithic tools, stone and shell beads and marine shell fragments. Radiocarbon dating provided a c.4200 cal. BC age, corresponding with the prevalent lithic evidence. Two other excavated sites yielded fewer materials, that were, however, diagnostically relevant. They indicate a diachronic occupation ongoing probably since the Late Neolithic till the end of that period, but some materials point to other stages of the Neolithic period as well. The appearance of marine shells suggests seasonal occupation and connections with coastal areas. It raises questions about the reasons for the settling of the Qumayrah valley.
Sharks in the lagoon? Fishing exploitation at the Neolithic site of Suwayh 1 (Ash Sharqiyah region, Arabian Sea, Sultanate of Oman)
Authors: Marrast Anaïs , Béarez Philippe , Charpentier Vincent 
Published: October 2019

AbstractThe study of the fish bones from the Neolithic shell midden of Suwayh 1, excavated in the 2000s, identified a total of 1060 identifiable fish bones, from 23 families, 33 genera and 28 different species. Radiocarbon dating demonstrates that the sites date to the early 6th to mid 5th millennium BC. The results follow an eight‐phase chronology highlighted by an earlier malacological study. The most important taxa were the Carcharhinidae (requiem shark), Rhinopteridae (cownose rays), Sparoidea (Sparidae and Lethrinidae: sea breams and emperors) and Ariidae (sea catfishes). The results of the fish study show that the Suwayh lagoon must have gradually opened up to the sea and been populated with mangroves. The unique presence of so many sharks at this site seems to indicate that the inhabitants had a special interest in shark fishing and that their location was ideal for this specialised activity. Two types of fishing nets and hooks have been discovered, which require the use of different fishing techniques.
Predictive serum markers for unexplained infertility in child‐bearing aged women
Authors: Qu Ting , Yan Meiling , Shen Wen‐Jun , Li Lingxiao , Zhu Ping , Li Zhouxuan , Huang Jihua , Han Tingting , Hu Wenhui , Zhou Ruinian , Li Penghao , Xu Lan , Huang Tianhua , Zhong Ying , Gu Jiang 
Published: October 2019

AbstractProblemUnexplained infertility (UI) represents about 25%‐40% of all infertility and is a formidable obstacle for successful pregnancy for child‐bearing aged women. However, up to now, there is no reliable method to predict this condition with high accuracy, thereby hindering early management of this condition.Method of studyOur prospective study consists of 84 child‐bearing aged women that were clinically diagnosed UI. Forty‐four matched healthy fertility (HF) women were served as controls. We examined the profiles of 25 hormones and cytokines that were likely related to pathogeneses and molecular pathways involved in UI with the technique of protein array. The samples were randomly stratified 7:3 into a training set and a testing set. We used the SMOTEboost model with 10 serum proteins in a clinical verification study to identify UI cases.ResultsThe predictor had an area under the receiver operating characteristic curve (AUC) of 0.788 with 24 serum protein features. The predictive performance in terms of AUC of the model with the top 10 important serum proteins in the clinical verification study to classify UI cases was 0.809. Three most significantly differentially expressed proteins (DEPs) were prolactin, monocyte chemotactic protein‐1 (MCP‐1), and leptin.ConclusionExamination of serum‐based protein profile changes could help to identify child‐bearing aged women at risk of UI. This would enable early detection and facilitate development of clinical strategies to treat UI and guide their planned parenthood. It may also give clues to pathogeneses of the condition of test subjects.
The association between ethnicity and pre‐eclampsia in Australia: A multicentre retrospective cohort study
Authors: Al‐Rubaie Ziad T.A. , Malcolm Hudson Harold , Jenkins Gregory , Mahmoud Imad , Ray Joel G. , Askie Lisa M. , Lord Sarah J. 
Published: October 2019

BackgroundRates of pre‐eclampsia vary between countries and certain ethnic groups. However, there is limited evidence about the impact of ethnicity on risk of pre‐eclampsia, beyond established clinical risk factors.AimsTo assess the association between ethnicity and pre‐eclampsia in Australia's diverse multi‐ethnic population.Materials and MethodsWe conducted a retrospective cohort study using the ObstetriX database. We included all women with a birth between January 2011 and December 2014, at Auburn, Blacktown/Mount‐Druitt and Westmead Hospitals in the Western Sydney Local Health District. We estimated the pre‐eclampsia rate overall, and by maternal ethnic group, defined by country of birth and primary language. We developed multivariable logistic regression models to estimate odds ratios (OR) and 95% confidence intervals (CIs) for pre‐eclampsia, adjusting for maternal age, body mass index, autoimmune disease, chronic hypertension, chronic renal disease, diabetes mellitus (type 1 or 2), and multiple pregnancy. A secondary analysis was restricted to nulliparous women.ResultsThere were 40 824 women evaluated, including 12 743 nulliparous women. Of these, 1448 (3.5%) developed pre‐eclampsia (range: Australian/New Zealand‐born English speakers 735/15 422 (4.8%); North‐East Asian women 51/4470 (1.1%)). Relative to Australian/New Zealand‐born English speakers, immigrants had a lower risk of pre‐eclampsia overall (adjusted OR 0.67; 95% CI 0.60–0.75); as did the three largest immigrant groups examined: Southern Asian (0.73; 0.62–0.85), Middle‐Eastern/African (0.55; 0.47–0.66) and North‐East Asian (0.33; 0.25–0.45) women. Findings were similar for nulliparous women.ConclusionsCertain immigrant groups are at lower risk of pre‐eclampsia than Australian/New Zealand‐born English‐speaking women. Understanding why this is so may lead to better screening and preventive strategies in higher‐risk women.
Smuggling, Trafficking, and Extortion: New Conceptual and Policy Challenges on the Libyan Route to Europe
Authors: Kuschminder Katie , Triandafyllidou Anna 
Published: October 2019

AbstractThis paper contributes a conceptual and empirical reflection on the relationship between human smuggling, trafficking and kidnapping, and extortion in Libya. It is based on qualitative interview data with Eritrean asylum seekers in Italy. Different tribal regimes control separate territories in Libya, which leads to different experiences for migrants depending on which territory they enter, such as Eritreans entering in the southeast Toubou controlled territory. We put forth that the kidnapping and extortion experienced by Eritreans in Libya is neither trafficking, nor smuggling, but a crime against humanity orchestrated by an organized criminal network. The paper details this argument and discusses the implications.
Maternal age and risk of cesarean section in women with induced labor at term—A Nordic register‐based study
Authors: Bergholt Thomas , Skjeldestad Finn E. , Pyykönen Aura , Rasmussen Steen C. , Tapper Anna‐Maija , Bjarnadóttir Ragnheiður I. , Smárason Alexander , Másdóttir Birna B. , Klungsøyr Kari , Albrechtsen Susanne , Källén Karin , Gissler Mika , Løkkegaard Ellen C. L. 
Published: October 2019

AbstractIntroductionOver the last decades, induction of labor has increased in many countries along with increasing maternal age. We assessed the effects of maternal age and labor induction on cesarean section at term among nulliparous and multiparous women without previous cesarean section.Material and methodsWe performed a retrospective national registry‐based study from Denmark, Finland, Iceland, Norway, and Sweden including 3 398 586 deliveries between 2000 and 2011. We investigated the impact of age on cesarean section among 196 220 nulliparous and 188 158 multiparous women whose labor was induced, had single cephalic presentation at term, and no previous cesarean section. Confounders comprised country, time‐period, and gestational age.ResultsIn nulliparous women with induced labor the rate of cesarean section increased from 14.0% in women less than 20 years of age to 39.9% in women 40 years and older. Compared with women aged 25‐29 years, the corresponding relative risks were 0.60 (95% confidence interval [95% CI] 0.57 to 0.64) and 1.72 (95% CI 1.66 to 1.79). In multiparous induced women the risk of cesarean section was 3.9% in women less than 20 years rising to 9.1% in women 40 years and older. Compared with women aged 25‐29 years, the relative risks were 0.86 (95% CI 0.54 to 1.37) and 1.98 (95% CI 1.84 to 2.12), respectively. There were minimal confounding effects of country, time‐period, and gestational age on risk for cesarean section.ConclusionsAdvanced maternal age is associated with increased risk of cesarean section in women undergoing labor induction with a single cephalic presentation at term without a previous cesarean section. The absolute risk of cesarean section is 3‐5 times higher across 5‐year age groups in nulliparous relative to multiparous women having induced labor.
SEEKING RENT IN THE INFORMAL SECTOR
Authors: KAR Saibal , MANDAL Biswajit , MARJIT Sugata , MUKHERJEE Vivekananda 
Published: October 2019

ABSTRACTRent seeking within the vast informal segment of the developing world is a relatively under‐explored topic in the interface of labor market policies and public economics. Moreover, how rent seeking and corruption within the informal segment gets affected by economic reforms targeted for the formal sector is rarely discussed in the literature. This paper fills the gap. We identify conditions under which economic reform in the formal segment will increase the rate of corruption or rent seeking in the informal sector and raise the pay‐off for those involved in rent‐seeking activities. When the formal sector contracts due to reforms, rent seeking in the informal sector may increase and lower the level of welfare unconditionally. Economic reforms may increase corruption instead of reducing it, unlike standard conjectures.
Thoracoscopic retrosternal gastric conduit resection in the supine position for gastric tube cancer
Authors: Horie Kazumasa , Oshikiri Taro , Kitamura Yu , Shimizu Masaki , Yamazaki Yuta , Sakamoto Hiroki , Ishida Sonoko , Koterazawa Yasufumi , Ikeda Taro , Yamamoto Masashi , Kanaji Shingo , Matsuda Yoshiko , Yamashita Kimihiro , Matsuda Takeru , Nakamura Tetsu , Suzuki Satoshi , Kakeji Yoshihiro 
Published: October 2019

AbstractIntroductionRecent advances in the treatment for esophageal cancer have improved the prognosis after esophagectomy, but they have led to an increased incidence of gastric tube cancer. In most patients who underwent retrosternal reconstruction, median sternotomy is performed; it is associated with a risk of postoperative bleeding and osteomyelitis, and pain often negatively affects respiration. Here, we report the first case of thoracoscopic retrosternal gastric conduit resection in the supine position (TRGR‐S).Materials and Surgical TechniqueA 75‐year‐old male patient was placed in the supine position. Four ports were placed in the left chest wall. The gastric tube was separated from the epicardium, sternum, and left brachiocephalic vein. Because of adhesions between the gastric tube and the right pleura, combined resection of the right pleura was performed. The dorsal side of the gastric tube was dissected before the ventral side, enabling the gastric tube to be suspended from the back of the sternum and, thus, making it easier to expose the surgical field. Next, pedicled jejunal reconstruction via the presternal route was performed. There were no postoperative complications. The pathological diagnosis was signet ring cell carcinoma (pT1b, pN0, M0, pStage I), indicating R0 resection.DiscussionTRGR‐S does not require sternotomy, reducing the risk of postoperative bleeding and osteomyelitis. In the presence of adhesions, TRGR‐S is safe and provides a good surgical view. It is also reliable procedure for resection of retrosternal gastric tube cancer, and it is ergonomic for surgeons.
Steroidal alkaloids efficient aromatase inhibitors with potential for the treatment of postmenopausal breast cancer
Authors: Ali Amjad , Jan Naeem Ullah , Ali Safdar , Ahmad Bashir , Ali Abid , Samrana Samrana , Jahan Azra , Ali Hamid , Khan Imtiaz Ali , Rahim Haroon , Ali Ijaz , Kifayatullah Muhammad , Amin Fazli 
Published: October 2019

AbstractPlant‐derived natural products are of great interest due to their diversity in modern drug discovery. Sarcococca saligna has been used for the treatment of different diseases. The present study was aimed at isolating phytochemical constituents including Alkaloid‐C (a), Dictyophlebine (b), Sarcovagine‐D (c) and Saracodine (d) Holaphylline (e) from Sarcococca saligna to investigate the anticancer effect of these compounds. These compounds were evaluated for inhibition of aromatase enzyme of breast cancer in assistance by molecular docking simulations to understand molecular interaction between the enzyme and ligands. The IC50 values of compound 1 and 5 were found 138.27 ± 0.01 µl and 12.91 ± 0.01 µl, respectively, and both were found active due to their bulky structures in comparison to the active site of aromatase enzyme. The standard drug exemestane showed potent activity in comparison with the test compounds, having IC50 values of 0.052 ± 0.01 µl. Both compounds showed favorable electrostatic interactions with the active site of aromatase enzyme but the shape and steric bulk of the compounds was the limiting factor in their inhibitory effects. New lead compounds could be generated after extensive modifications guided by computational and experimental tools as a possible anticancer agents by targeting aromatase enzyme.
Association between the Khorana score and pulmonary embolism risk in patients with advanced stage lung cancer
Authors: Dapkevičiūtė Austėja , Daškevičiūtė Aurelija , Zablockis Rolandas , Kuzaitė Aušrinė , Jonušienė Gintarė , Diktanas Saulius , Danila Edvardas 
Published: October 2019

AbstractIntroductionThe Khorana score may help physicians to identify patients at high risk of Pulmonary embolism (PE) and decide who is eligible for thromboprophylaxis, however, its role in lung cancer patients remains unclear.ObjectivesThe aim of this study was to evaluate association between the Khorana score and risk of PE development among advanced stage lung cancer inpatients treated with chemotherapy.Materials and methodsA retrospective cohort study included 2008‐2017 year data of 217 lung cancer inpatients with IIIB and IV clinical stages receiving chemotherapy. The Khorana score was evaluated and patients were divided in two groups: a group of patients with 1 point and a group of patients with 2 or more points of the Khorana score.ResultsThe study population included 46 (21.2%) female and 171 (78.8%) male patients whose median age was 62. During median observation period of 308.5 days 26 (11.9%) patients developed PE. Study included 137 patients with 1 point and 80 patients with 2 or more points of the Khorana score. The frequency of PE was 17 (12.4%) among patients with 1 point and 9 (11.3%) among patients with 2 points of the Khorana score. The relative risk of PE for patients with 2 or more points was 0.895 (95% CI = 0.379‐2.114), P = 0.800.ConclusionThe Khorana score was not associated with PE development risk among advanced stage lung cancer inpatients treated with chemotherapy.