bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cingulum as a marker of individual differences in neurocognitive development
Authors: Bathelt Joe , Johnson Amy , Zhang Mengya , Astle Duncan E. 
Published: February 2019

AbstractThe canonical approach to exploring brain-behaviour relationships is to group individuals according to a phenotype of interest, and then explore the neural correlates of this grouping. A limitation of this approach is that multiple aetiological pathways could result in a similar phenotype, so the role of any one brain mechanism may be substantially underestimated. Building on advances in network analysis, we used a data-driven community-clustering algorithm to identify robust subgroups based on white-matter microstructure in childhood and adolescence (total N = 313, mean age: 11.24 years). The algorithm indicated the presence of two equal-size groups that show a critical difference in fractional anisotropy (FA) of the left and right cingulum. Applying the brain-based grouping in independent samples, we find that these different ‘brain types’ had profoundly different cognitive abilities with higher performance in the higher FA group. Further, a connectomics analysis indicated reduced structural connectivity in the low FA subgroup that was strongly related to reduced functional activation of the default mode network. These results provide a proof-of-concept that bottom-up brain-based groupings can be identified that relate to cognitive performance. This provides a first demonstration of a complimentary approach for investigating individual differences in brain structure and function, particularly for neurodevelopmental disorders where researchers are often faced with phenotypes that are difficult to define at the cognitive or behavioural level.
Design, Synthesis, and Biological Evaluation of Phenol Bioisosteric Analogues of 3-Hydroxymorphinan
Authors: Li Ziqiang , Bao Xiuqi , Bai Xiaoguang , Zhang Guoning , Wang Juxian , Zhu Mei , Wang Yue , Shang Junmei , Sheng Chanjuan , Zhang Dan , Wang Yucheng 
Published: February 2019

AbstractThe neuroprotective agent 3-hydroxymorphinan (3-HM) is a well-documented and highly safe therapeutic intervention for the inflammatory-related effects of Parkinson’s disease (PD). However, the bioavailability of 3-HM is very low due to the rapid first-pass metabolism of the phenolic moiety. In the present study, we sought to improve the metabolic stability and overall pharmacokinetic profile of 3-HM. Based on an iterative design process that a suitably arranged heterocycle with an NH group would serve as the metabolically stable isostere of the phenolic group, we designed and synthesized two analogues of 3-HM. Benzimidazolone compound 8 (imidazolone-morphinan) was comparable in activity to 3-HM against lipopolysaccharide (LPS)-induced inflammatory responses in microglial BV2 cells and in vivo animal experiments (MPTP-induced PD mouse model). Moreover, the in vitro study showed that imidazolone-morphinan was non-toxic to microglia, indicating its high safety. Considering the favourable and unique preclinical profiles, compound 8 was nominated as a candidate for further clinical development.
Toughening of Dental Composites with Thiourethane-Modified Filler Interfaces
Authors: Fugolin Ana P. , Sundfeld Daniel , Ferracane Jack L. , Pfeifer Carmem S. 
Published: February 2019

AbstractStress of polymerization is one of the most significant drawbacks of dental resin composites, since it is related to poor marginal adaptation, postoperative pain, and secondary caries. Previous studies have shown that thiourethane oligomers incorporated into the organic matrix represents a promising strategy to reduce stress and increase fracture toughness in dental composites. However, this strategy promotes a significant increase of the viscosity system, which may represent a challenge for clinical application. The objective of this study was to functionalize the surface of inorganic filler particles with thiouretanes and evaluate the impact on mechanical properties and kinetics of polymerization. Our results showed that composites filled with thiourethane-silanized inorganic fillers showed up to 35% lower stress while doubling mechanical properties values. This was achieved with no prejudice to the viscosity of the material and following a clinically acceptable photoactivation protocol.
I-BLEND, a campus-scale commercial and residential buildings electrical energy dataset
Authors: Rashid Haroon , Singh Pushpendra , Singh Amarjeet 
Published: February 2019

AbstractEfficient energy consumption at the building level is vital for sustainability. Providing energy efficient systems and solutions requires an understanding of how energy gets consumed. However, there is a general lack of large-scale open datasets about the energy consumption of buildings, which hinders the research. The recent emergence of smart energy meters makes it possible to collect such data, which can then be used for analysis. In this paper, we release I-BLEND, 52 months of electrical energy dataset at a one-minute sampling rate from commercial and residential buildings of an academic institute campus in an emerging economy, India. Also, we provide occupancy datasets at a 10-minute sampling rate for each of the campus buildings. To the best of our knowledge, this is the first such dataset from India. Public availability of such fine-granular data will allow users to perform different research tasks such as analyzing the impact of weather or occupancy schedule on energy consumption, detecting anomalies, and developing algorithms for predictive maintenance.
Stable isotope variations of daily precipitation from 2014–2018 in the central United States
Authors: Tian Chao , Wang Lixin 
Published: February 2019

AbstractStable isotopes of hydrogen and oxygen (δ2H, δ18O and δ17O) serve as powerful tracers in hydrological investigations. To our knowledge, daily precipitation isotope record especially 17O-excess is rare in the mid-latitudes. To fill such knowledge gap, daily precipitation samples (n=446) were collected from June 2014 to May 2018 in Indianapolis, Indiana, U.S. A Triple Water Vapor Isotope Analyzer (T-WVIA) based on Off-Axis Integrated Cavity Output Spectroscopy (OA-ICOS) technique was used to concurrently measure precipitation isotopic variations (δ2H, δ18O and δ17O). Meanwhile, 17O-excess and d-excess as second-order isotopic variables were calculated to provide additional information on precipitation formation and transport mechanisms. This study presents a four-year daily precipitation isotope dataset for mid-latitudes, and makes it available to researchers around the world who may use it as a reference for site comparisons and for assessing global hydrological models.
A draft genome assembly of the solar-powered sea slug Elysia chlorotica
Authors: Cai Huimin , Li Qiye , Fang Xiaodong , Li Ji , Curtis Nicholas E. , Altenburger Andreas , Shibata Tomoko , Feng Mingji , Maeda Taro , Schwartz Julie A. , Shigenobu Shuji , Lundholm Nina , Nishiyama Tomoaki , Yang Huanming , Hasebe Mitsuyasu , Li Shuaicheng , Pierce Sidney K. , Wang Jian 
Published: February 2019

AbstractElysia chlorotica, a sacoglossan sea slug found off the East Coast of the United States, is well-known for its ability to sequester chloroplasts from its algal prey and survive by photosynthesis for up to 12 months in the absence of food supply. Here we present a draft genome assembly ofE. chloroticathat was generated using a hybrid assembly strategy with Illumina short reads and PacBio long reads. The genome assembly comprised 9,989 scaffolds, with a total length of 557 Mb and a scaffold N50 of 442 kb. BUSCO assessment indicated that 93.3% of the expected metazoan genes were completely present in the genome assembly. Annotation of theE. chloroticagenome assembly identified 176 Mb (32.6%) of repetitive sequences and a total of 24,980 protein-coding genes. We anticipate that the annotated draft genome assembly of theE. chloroticasea slug will promote the investigation of sacoglossan genetics, evolution, and particularly, the genetic signatures accounting for the long-term functioning of algal chloroplasts in an animal.
Automated evaluation of consistency within the PubChem Compound database
Authors: Dashti Hesam , Wedell Jonathan R. , Westler William M. , Markley John L. , Eghbalnia Hamid R. 
Published: February 2019

AbstractIdentification of discrepant data in aggregated databases is a key step in data curation and remediation. We have applied the ALATIS approach, which is based on the international chemical shift identifier (InChI) model, to the full PubChem Compound database to generate unique and reproducible compound and atom identifiers for all entries for which three-dimensional structures were available. This exercise also served to identify entries with discrepancies between structures and chemical formulas or InChI strings. The use of unique compound identifiers and atom nomenclature should support more rigorous links between small-molecule databases including those containing atom-specific information of the type available from crystallography and spectroscopy. The comprehensive results from this analysis are publicly available through our webserver [http://alatis.nmrfam.wisc.edu/].
The association ofFOXP3gene polymorphisms with cancer susceptibility: a comprehensive systemic review and meta-analysis
Authors: Chen Yan , Qi Xiaoxue , Bian Ce , Ling Chen , Yi Tao , Mu Xiyan , Zhao Xia 
Published: February 2019

AbstractThe role of forkhead box P3 (FOXP3) protein in tumorigenesis has long been controversial and existing data on the association between FOXP3 gene polymorphisms and cancer susceptibility were inconsistent. Here, we conducted a meta-analysis to better clarify the relationship. A comprehensive search of studies published from July 2008 to June 2018 was conducted. The statistical analyses of the pooled odds ratios (ORs) and the corresponding 95% confidence intervals (95% CIs) were performed using the Revman 5.2 software. A total of 12 articles with 19 case–control studies and 10389 participants were included. Three FOXP3 polymorphisms and six cancer types were evaluated. While no significant results were observed in overall and breast cancer groups for rs3761548 (A/C) polymorphisms, the pooled data showed an elevated risk of cancer in variant AA genotypes and A allele for Chinese population (AA vs. AC+CC: OR = 1.61, 95% CI = 1.09, 2.39; AA vs. CC: OR = 1.74, 95% CI = 1.05, 2.89; A vs. C: OR = 1.34, 95% CI = 1.00, 1.78). Neither the overall group analyses nor the subgroup analyses stratified by cancer type and ethnicity proposed any significant association of rs2280883 (C/T) and rs3761549 (T/C) polymorphisms with cancer susceptibility. This meta-analysis suggested that FOXP3 rs3761548 (A/C) polymorphisms were associated with increased cancer risk in Chinese population while rs2280883 (C/T) and rs3761549 (T/C) polymorphisms were not. More large-sample researches with diverse ethnicities and cancer types are needed to draw a concrete conclusion.
Engineering of receptor-binding proteins in bacteriophages and phage tail-like bacteriocins
Authors: Dams Dorien , Brøndsted Lone , Drulis-Kawa Zuzanna , Briers Yves 
Published: February 2019

Abstract
Bacteriophages and phage tail-like bacteriocins (PTLBs) rely on receptor-binding proteins (RBPs) located in tail fibers or spikes for an initial and specific interaction with susceptible bacteria. Bacteriophages kill bacteria through a lytic, replicative cycle, whereas PTLBs kill the target through membrane depolarization in a single hit mechanism. Extensive efforts in the engineering of RBPs of both phages and PTLBs have been undertaken to obtain a greater understanding of the structural organization of RBPs. In addition, a major goal of engineering RBPs of phages and PTLBs is the production of antibacterials with a customized spectrum. Swapping of the RBP of phages and PTLBs results in a shift in activity spectrum in accordance with the spectrum of the new RBP. The engineering of strictly virulent phages with new RBPs required significant technical advances in the past decades, whereas the engineering of RBPs of PTLBs relied on the traditional molecular techniques used for the manipulation of bacteria and was thus relatively straightforward. While phages and PTLBs share their potential for specificity tuning, specific features of phages such as their lytic killing mechanism, their self-replicative nature and thus different pharmacokinetics and their potential to co-evolve are clear differentiators compared with PTLBs in terms of their antibacterial use.
The Relationship Between Culture, Quality of Life, and Stigma in Hispanic New Mexicans With Dysphagia: A Preliminary Investigation Using Quantitative and Qualitative Analysis
Authors: Padilla Aaron H. , Palmer Phyllis M. , Rodríguez Barbara L. 
Published: February 2019

Purpose
The purpose of this investigation was to (a) identify the relationship between level of acculturation, and quality of life (QOL) and stigma and (b) explore the QOL experiences for Hispanic New Mexicans with dysphagia.

Method

This study includes 7 New Mexicans who self-identified as Hispanic. This prospective investigation was completed in 2 phases. In the quantitative phase, all participants completed the (a) the SWAL-QOL (
McHorney et al., 2000
), (b) the Neuro-QoL Stigma subtest (
Gershon et al., 2012
), and (c) the Acculturation Rating Scale for Mexican Americans–II (ARSMA-II;
Cuellar, Arnold, & Maldonado, 1995
). In the qualitative phase, 3 participants were selected from the quantitative phase to complete the qualitative phase. These participants were selected to allow for distribution across levels of acculturation, and each of them participated in interviews designed to explore QOL experiences. Interviews were analyzed to identify themes. The occurrence of themes is discussed as a function of level of acculturation.

Results
There is no clear relationship between acculturation and QOL. A strong nonsignificant correlation was observed between acculturation and stigma. QOL experiences, as identified from the interviews, were classified into 2 broad categories: emotional experiences (stigma, distrust, fear, frustration, religion, and impact) and swallow safety (symptoms, treatment, triggers, and compensatory strategies).

Conclusions
Level of acculturation did not relate to measures of mental health or fatigue. Yet, both quantitative and qualitative analyses support a relationship between level of acculturation, and symptom reporting and religion, as well as patient perception of stigma.
Equipping Nurses and Care Staff to Manage Mealtime Difficulties in People With Dementia: A Systematic Scoping Review of Training Needs and Interventions
Authors: Faraday James , Salis Christos , Barrett Anne 
Published: February 2019

Purpose
Mealtime difficulties are prevalent in dementia, posing major challenges to people with dementia (PWD), carers, and clinical services. Speech-language pathologists have a recognized role in providing training to carers of PWD who have mealtime difficulties. The aims of this study are (a) to identify the training needs of nurses and care staff with regard to managing mealtime difficulties in PWD, (b) to describe existing training interventions on this topic, and (c) to investigate the extent to which these interventions are relevant to the needs of nurses and care staff.

Method
A systematic search was carried out to identify studies relevant to the aims of the review. Data were extracted and then synthesized using thematic analysis and a synthesis matrix. Study quality was appraised using a validated appraisal tool.

Results
Various themes were identified in relation to the training needs of nurses and other care staff who manage mealtime difficulties in PWD. These were as follows: person-centered care; dealing with uncertainty; strategies, skills, and knowledge; and creating the right environment. Existing training interventions were described and compared against the training needs. The review found some correspondence between interventions and staff needs, but also some gaps.

Conclusions
Training interventions on this topic should be more systematically developed and better reported to facilitate effective implementation. Evidence to date indicates that training should do more to help staff deal with uncertainty. Further research assessing the benefits of speech-language pathologists' involvement in the development of training interventions is recommended because of this profession's specialist skills and knowledge with regard to both dysphagia and communication.
Reading Development in Children With Cochlear Implants Who Communicate via Spoken Language: A Psycholinguistic Investigation
Authors: Bell Nicola , Angwin Anthony J. , Wilson Wayne J. , Arnott Wendy L. 
Published: February 2019

Purpose
This study sought to comprehensively examine the reading skills and subskills of children with cochlear implants (CIs) and gain insight into the processes underlying their early reading development.

Method

Fourteen 6- to 9-year-old children with CIs were assessed on a range of reading and spoken language measures. Their performances were compared to a control group of 31 children with normal hearing (NH) of the same chronological and mental age. Group differences were examined using
t
tests and regression modeling.

Results
Children with CIs performed significantly worse than children with NH on reading accuracy, phonological processing, and spoken language tasks. The predominant predictor of reading comprehension was word reading accuracy for the CI group and listening comprehension for the NH group. Word reading profiles were similar across groups, with orthographic and phonological processing skills both contributing significant variance.

Conclusions
Children with CIs demonstrated more early reading difficulties than their peers with NH. As predicted by the Simple View of Reading model, successful reading comprehension for all children related to skills in listening comprehension and word recognition. The CI group's increased reliance on word reading accuracy when comprehending written text may stem from reduced word recognition automaticity. Despite showing reduced reading accuracy, children with CIs appeared to draw on orthographic and phonological skills to a similar degree as children with NH when reading words in isolation.
Toward Routine Assessments of Auditory Filter Shape
Authors: Shen Yi , Kern Allison B. , Richards Virginia M. 
Published: February 2019

Purpose
A Bayesian adaptive procedure, that is, the quick auditory filter (qAF) procedure, has been shown to improve the efficiency for estimating auditory filter shapes of listeners with normal hearing. The current study evaluates the accuracy and test–retest reliability of the qAF procedure for naïve listeners with a variety of ages and hearing status.

Method

Fifty listeners who were naïve to psychophysical experiments and exhibit wide ranges of age (19–70 years) and hearing threshold (−5 to 70 dB HL at 2 kHz) were recruited. Their auditory filter shapes were estimated for a 15-dB SL target tone at 2 kHz using both the qAF procedure and the traditional threshold-based procedure. The auditory filter model was defined using 3 parameters: (a) the sharpness of the tip portion of the auditory filter,
p
; (b) the prominence of the low-frequency tail of the filter, 10log(
w
); and (c) the listener's efficiency in detection, 10log(
K
).

Results
The estimated parameters of the auditory filter model were consistent between 2 qAF runs tested on 2 separate days. The parameter estimates from the 2 qAF runs also agreed well with those estimated using the traditional procedure despite being substantially faster. Across the 3 auditory filter estimates, the dependence of the auditory filter parameters on listener age and hearing threshold was consistent across procedures, as well as consistent with previously published estimates.

Conclusions
The qAF procedure demonstrates satisfactory test–retest reliability and good agreement to the traditional procedure for listeners with a wide range of ages and with hearing status ranging from normal hearing to moderate hearing impairment.
Subwavelength and low‐profile element using metallic hole for reflected antenna array
Authors: Hou Yuefeng , Li Yue , Zhang Zhijun 
Published: February 2019

In this Letter, a novel subwavelength and low‐profile element is proposed for the reflected antenna array applications. By using the metallic hole, the proposed element achieves a smaller dimension with the period of 0.1125 wavelength and the profile of 0.036 wavelength at the centre frequency of 13.5 GHz. The element obtains a wide reflected phase shifting range of 337.2° in such a small dimension. The reflected magnitude and phase are less sensitive to the incidence angle over a large range from +60° to −60°. To verify the function of the proposed element with a metallic hole, a reflected antenna array with 2724 elements is designed, fabricated, and measured. The array achieves a maximum peak gain of 23.30 dBi at 13.25 GHz with a high aperture efficiency of 61.05%.
Calibration of a panoramic 3D reconstruction system
Authors: Córdova‐Esparza Diana Margarita , González‐Barbosa José‐Joel , Terven Juan R. , Hurtado‐Ramos Juan B. , Almaraz‐Cabral César‐Cruz 
Published: February 2019

Owing to their large field of view, a catadioptric imaging system is widely used in several research areas, including robot navigation, surveillance, and three‐dimensional (3D) reconstruction. The modelling and calibration of these systems allow the accurate measurement of objects. This paper presents a calibration method for a panoramic 3D reconstruction system based on pattern projection composed of two modules. The first module, which contains a charged coupled device camera and a parabolic mirror allows the acquisition of catadioptric images. The second module is a catadioptric projection system made of a light projector and a parabolic mirror that generates a projected pattern over the target for reconstruction purposes. Both the modules are calibrated independently. The method achieves a reprojection error of 0.6 pixels in the camera module and 1.2 pixels in the catadioptric projection system. To evaluate the performance of the proposed method, the results show 3D reconstructions of multiple objects with tolerances around 1.3 mm.
Adaptive control technique for suppression of resonance in grid‐connected PV inverters
Authors: Goh Hongsoo , Armstrong Matthew , Zahawi Bashar 
Published: February 2019

Grid operating conditions have a significant effect on the harmonic and resonant performance of grid‐connected photovoltaic (PV) inverters and changes in grid impedance can cause a notable change in the resonant excitation between the PV inverter and the grid. This study proposes an adaptive control algorithm for grid‐connected PV inverters to suppress the resonance condition excited by grid inductance variation, resulting from the dynamic changes in the operating conditions of the distribution network. The causes of resonance between grid‐connected PV inverters and the distribution grid are discussed and the design of an active band‐pass filter for capturing resonance is described. The proportional gain within the proportional–integral controller is then adaptively controlled in real time to compensate for changes in the grid impedance and suppress resonant excitation while maintaining excellent low‐order harmonic performance compared with alternative fixed gain controller techniques, particularly for systems with high values of grid inductance. The performance of the proposed controller is experimentally verified using a 240 V, 2 kVA single‐phase grid‐connected inverter.