bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adherence to colonoscopy at 1 year following resection of localized colon cancer: a retrospective cohort study
Authors: Neugut Alfred I. , Zhong Xiaobo , Lebwohl Benjamin , Hillyer Grace C. , Accordino Melissa K. , Wright Jason D. , Kiran Ravi P. , Hershman Dawn L. 
Published: March 2018

Background: For patients with stages I-III colon cancer who have undergone surgical resection, guidelines recommend surveillance colonoscopy at 1 year. However, limited data exist on adherence and associated factors. We aimed to determine the rate of adherence to surveillance colonoscopy at 1 year among nonmetastatic colon cancer patients who underwent resection and factors associated with adherence. Methods: In this population-based retrospective cohort study, the Surveillance, Epidemiology, and End Results (SEER)–Medicare database was used. We identified patients with stages I-III colon cancer who underwent surgical resection and survived >3 years without recurrence (no chemotherapy after 8 months) from 2002–2011. Our primary outcome was a colonoscopy claim 10–15 months after resection. We used multivariable regression analysis to assess associations between sociodemographic and clinical factors and receipt of timely colonoscopy. Results: Among 28,732 patients who survived >3 years without recurrence, 7967 (28%) did not undergo colonoscopy; 12,033 (42%) had it at one year, with 3159 (11%) before 10 months and 5573 (19%) after 15 months. Decreased adherence was associated with older age; being male versus female; being black or Hispanic versus white; higher tumor stage; left-sided tumors versus right sided; and increased comorbidities. Chemotherapy receipt was associated with increased adherence (odds ratio 2.06; 95% confidence interval 1.88–2.24). Conclusions: In a large population-based sample of individuals aged ⩾ 65 years, only 42% of colon cancer survivors underwent 1-year surveillance colonoscopy. Demographic and clinical factors were associated with adherence.
Incarcerated Plantar Dislocation of the First Metatarsophalangeal Joint: Reduction Using Intra-articular Saline Injection
Authors: Bohl Daniel D. , Hamid Kamran S. , Walton David M. 
Published: March 2018

Plantar dislocation of the first metatarsophalangeal (MTP) joint is exceedingly rare, and in prior reported cases, simple closed manipulation easily enabled reduction. We present here the first reported plantar dislocation that failed closed manipulation. We also report a technique involving injection of saline into the joint to facilitate reduction. The saline insufflation likely relieves buttonholing of the metatarsal head through the dorsal joint capsule. For first MTP joint plantar dislocations that fail reduction with manipulation, we recommend attempting injection of the joint with saline prior to subjecting the patient to open reduction. Levels of Evidence: Therapeutic, Level IV: Case report
Proliferation, Migration, and ECM Formation Potential of Human Annulus Fibrosus Cells Is Independent of Degeneration Status
Authors: Hondke Sylvia , Cabraja Mario , Krüger Jan Philipp , Stich Stefan , Hartwig Tony , Sittinger Michael , Endres Michaela 
Published: March 2018

Objective The objective was to evaluate the proliferating, migratory and extracellular matrix (ECM) forming potential of annulus fibrosus cells derived from early (edAFC) or advanced (adAFC) degenerative tissue and their usability as a possible cell source for regenerative approaches for AF closure. Design EdAFC ( n = 5 Pfirrman score of 2-3) and adAFC (n = 5 Pfirrman score of 4-5) were isolated from tissue of patients undergoing spine stabilizing surgery. Cell migration on stimulation with human serum (HS), platelet-rich plasma (PRP), and transforming growth factor β-3 (TGFB3) was assessed by migration assay and proliferation was assessed on stimulation with HS. Induction of ECM synthesis was evaluated by gene expression analysis of AF-related genes in three-dimensional scaffold cultures that have been stimulated with 5% PRP or 10 ng/mL TGFB3 and histologically by collagen type I, type II, alcian blue, and safranin-O staining. Results EdAFC and adAFC were significantly attracted by 10% HS and 5% PRP. Additionally, both cell groups proliferated under stimulation with HS. Stimulation with 10 ng/mL TGFB3 showed significant induction of gene expression of collagen type II and aggrecan, while 5% PRP decreased the expression of collagen type I. Both cell groups showed formation of AF-like ECM after stimulation with TGFB3, whereas stimulation with PRP did not. Conclusions Our study demonstrated that AF cells retain their potential for proliferation, migration, and ECM formation independent of the degeneration status of the tissue. Proliferation, migration, and ECM synthesis of the endogenous AF cells can be supported by different supplements. Hence, endogenous AF cells might be a suitable cell source for a regenerative repair approaches.
Vesico-vaginal fistulae in the resource-limited setting: current status and the challenges that lie ahead, all you need to know for those practicing in a well-resourced setting
Authors: Beardmore-Gray Alice , Greenwell Tamsin 
Published: March 2018

In this review we examine the incidence, aetiology, pathology and classification of vesico vaginal fistulae (VVF) in the resource poor setting. We compare the diagnosis, management and outcomes of VVF repair in resource-poor countries to current practice in the well-resourced setting, finally looking ahead to the future and the changes we need to make on a global scale in order to prevent this debilitating condition. There is a clear need for more accurate data collection and classification systems appropriate to the setting. Lack of facilities such as radiology limit diagnostic capabilities and options for repair, however outcome data from resource poor countries is promising. Most importantly, a holistic approach, which examines not just the physical aspects of the condition but the social and cultural factors predisposing women to VVF, needs to be adopted when considering prevention and management of this injury. Level of evidence: Not applicable as this is a review article.
Characterization of organo-kenyaites: thermal stability and their effects on eosin removal characteristics
Authors: Kooli F. , Liu Y. , Hbaieb K. , Ching O.Y. , Al-Faze R. 
Published: March 2018

ABSTRACTOrgano-kenyaites were prepared from a cetyltrimethylammonium hydroxide (C16TMAOH) solution and solid sodium kenyaite (Na2Si22O45.10H2O) mixture. The effect of the initial cetyltrimethylammonium solution on the structure of the intercalated materials was investigated by CHN analyses, X-ray diffraction (XRD), thermogravimetric analysis, SEM, and 29Si and 13C solid NMR techniques. For C16TMAOH concentration 0.25 mM, the Na+ cations were fully exchanged. Initial C16TMAOH concentrations higher than 0.25 mM had little effect on the intercalated amount of C16TMA+ cations. The organic cations content reached a plateau of 0.66 mmol/g. The arrangement model of C16TMA+ cations corresponded to a tilt of the organic cations to the silicate layers with an angle of 42° as deduced by XRD studies. The C16TMA+ cations exhibited mainly trans-configuration of the methyl chains, as was shown by solid 13C NMR. The thermal stability of the organo-silicates was studied using in situ FTIR and in situ XRD in the range 25–450°C. The C16TMA-kenyaites were stable at temperatures below 200°C. They collapsed at higher temperatures due to the decomposition of the intercalated surfactants. These organo-kenyaites were used to remove the acidic dye molecule, eosin. The removal tests were performed at varying conditions of initial dye concentrations, organic content in the organo-kenyaites and heating temperatures. In general, the organic modification improved the removal capacity of the Na-kenyaite from 2 mg of eosin/g to 60 mg of eosin/g, and this capacity was related to the organic contents and the calcination temperatures of the organo-kenyaites.
VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites
Authors: Czogalla Katrin J. , Liphardt Kerstin , Höning Klara , Hornung Veit , Biswas Arijit , Watzka Matthias , Oldenburg Johannes 
Published: March 2018

Key PointsVKORC1 is more sensitive than VKORC1L1 to OAC inhibition, whereby 4-hydroxycoumarin rodenticides are equally effective. In silico and in vitro analysis revealed OAC binding sites that are different for VKORC1 and VKORC1L1.
Inhibition of miR-34a-5p alleviates hypoxia-reoxygenation injury by enhancing autophagy in steatotic hepatocytes
Authors: Li Chuanjiang , Wang Kai , Guo Linghong , Sun Hang , Huang Hai , Lin XinXin , Li Qingping 
Published: March 2018

ABSTRACT
Hypoxia-reoxygenation (H/R) injury in steatotic hepatocytes has been implicated in liver dysfunction after liver transplantation. MicroRNAs (miRs) play important roles in regulating several cell biology mechanisms related to H/R injury. However, the role of miRs in regulating H/R injury in steatotic hepatocytes is still unclear. We established an in vitro model for studying H/R injury in steatotic hepatocytes and identified miR-34a-5p as a miR that was substantially upregulated in steatotic hepatocytes under H/R challenge. MiR-34a-5p expression was modified by transfecting miR-34a-5p mimic and inhibitor into H/R-challenged steatotic hepatocytes. We found that inhibition of miR-34a-5p alleviated H/R-induced apoptosis and promoted post-H/R proliferation in steatotic hepatocytes. Whereas, overexpression of miR-34a-5p augmented H/R-induced apoptosis and prohibited post-H/R proliferation. By examining autophagy, our data demonstrated that miR-34a-5p suppressed autophagy in H/R-challenged steatotic hepatocytes, induction of autophagy partially rescued the exaggeration of H/R injury induced by miR-34a-5p mimic, while inhibition of autophagy impaired the protection of the miR-34a-5p inhibitor against H/R injury. In conclusion, miR-34a-5p is crucial in exaggerating H/R injury, likely by suppressing autophagy in steatotic hepatocytes. Inhibition of miR-34a may be a promising strategy to protect steatotic hepatocytes against H/R-injury.
A PRIMEIRA DÉCADA DO PROUNI: ESTUDO SOBRE A EFICIÊNCIA A PARTIR DA ANÁLISE ECONÔMICA DO DIREITO
Authors: Kalil Gilberto Alexandre de Abreu , Gonçalves Oksandro Osdival 
Published: March 2018

Para tornar mais efetivo o direito à educação, o Estado pode criar políticas públicas, como o Programa Universidade para Todos (Prouni), instituído pelo Governo Federal no ano de 2005, que concede bolsas de estudo integrais e parciais a estudantes de baixa renda em instituições de Ensino Superior privadas, que em contrapartida ficam isentas do pagamento de tributos federais. Nesse cenário, o principal objetivo do presente artigo é avaliar a referida política pública por uma perspectiva interdisciplinar, utilizando-se a Análise Econômica do Direito (AED). Assim, o artigo analisa se a primeira década de existência do Prouni, compreendida entre os anos de 2005 a 2015, produziu resultados eficientes para a finalidade que ensejou a concepção da política pública, qual seja, concretizar o direito fundamental social à educação pela ampliaçãodo acesso ao Ensino Superior aos estudantes menos favorecidos economicamente.
A (IN)EFICIÊNCIA DO PROCESSO JUDICIAL ELETRÔNICO NA SOCIEDADE DA INFORMAÇÃO
Authors: Santanna Gustavo Da Silva , Limberger Temis 
Published: March 2018

O presente artigo tem objetivo fazer uma análise crítica quanto à (in)eficiência do processo judicial eletrônico diante da sociedade da informação. A inserção do princípio da eficiência como básico para a Administração Pública (com a Emenda Constitucional nº 19 em 1998) obrigou os Poderes Executivo, Legislativo e Judiciário a pautarem suas condutas por meio de resultados. Nesse mesmo momento histórico, a evolução das tecnologias de informação e comunicação acabaram por reestruturar a sociedadecontemporânea. A utilização da informática, como ferramenta integrada ao cotidiano dos indivíduos estabeleceu novas premissas, tanto sociais quanto estatais. Com isso, não somente o Poder Executivo vem passando por transformações substanciais no seu trato com os cidadãos. O Poder Judiciário necessitou, também, estabelecer novos parâmetros, culminando com a criação do processo judicial eletrônico. Assim, esse sistema se apresenta não somente como uma aplicação do princípio da eficiência, mas também como uma transformação do processo judicial à vida em rede. Contudo, ainda que tenha apresentado, inicialmente, muitas vantagens frente ao processo judicial “físico”, tem-se demonstrado ineficiente diante da evolução tecnológica, apresentando falta de interoperabilidade entre os sistemas, por exemplo.
TRANSMISSÃO DE CONHECIMENTOS RELIGIOSOS NA SOCIEDADE DA INFORMAÇÃO E SUA TUTELA JURÍDICA EM FACE DO DIREITO AMBIENTAL CONSTITUCIONAL
Authors: Fiorillo Celso Antonio Pacheco , Ferreira Renata Marques 
Published: March 2018

A transmissão de conhecimentos religiosos, associada às questões existenciais surgidas em diferentes culturas e, em nosso país, vinculada aos modos de viver dos diferentes grupos formadores da sociedade brasileira, tem seu balizamento definido em nosso Estado Democrático de Direito delimitada de forma abrangente a partir do conceito jurídico de religião como um bem cultural estruturado em face da tutela jurídica constitucional do meio ambiente cultural (arts. 215/216 da Carta Magna). Destarte pode ser validamente desenvolvida e propalada por diferentes formas, processos ou veículos existentes no âmbito da comunicação social (Art.220 e segs da CF) e tutelada juridicamente no plano do meio ambiente digital como efetiva e eficiente forma de transmitir seus valores na sociedade da informação em que vivemos. O tema não se esgota, pois tão somente na “convergência de três normas constitucionais: a que prevê o ensino religioso (artigo 210, parágrafo 1º), a que assegura a liberdade religiosa (artigo 5º, inciso VI) e a que consagra o princípio da laicidade do Estado (artigo 19, inciso I)”, porém necessariamente a partir de interpretação constitucional sistemática mais ampla (direito ambiental constitucional) com a necessária aplicação do regramento jurídico destinado a tutelar o uso dos espaços difusos destinados não só à transmissão de conhecimentos religiosos na sociedade em que vivemos, mas à disseminação de toda e qualquer manifestação do pensamento, à criação e expressão da pessoa humana visando a assegurar sua dignidade (art.1º, III).
POLÍTICAS MIGRATÓRIAS NO BRASIL E A INSTITUIÇÃO DOS “INDESEJADOS”: A CONSTRUÇÃO HISTÓRICA DE UM ESTADO DE EXCEÇÃO PARA ESTRANGEIROS
Authors: Carneiro Cynthia Soares 
Published: March 2018

A participação dos imigrantes na I Conferência sobre Migração e Refúgio resultou em um levantamento circunstanciado da situação de restrições a direitos a que estão sujeitos no Brasil. Evidenciou-se, igualmente, que tais restrições são consequência de normas e práticas institucionais arraigadas junto aos órgãos brasileiros responsáveis pelo controle migratório. As recomendações apresentadas pelos imigrantes no âmbito da conferência contribuíram para a edição da Lei 13.445/2017, denominada Lei de Migração. A partir do trabalho etnográfico realizado junto a COMIGRAR, este artigo se dedica a um estudo exploratório relativo aos decretos migratórios editados desde o período monárquico, percorrendo o período getulista e suas políticas higienistas e eugenéticas, até o recém-revogado Estatuto do Estrangeiro. A abordagem tem como objetivo evidenciar uma tradição discriminatória que tem levado à precarização do trabalho do estrangeiro no Brasil. De acordo com os conceitos formulados por Giorgio Agamben acerca do homo sacer e do estado de exceção na modernidade, procura-se demonstrar que tal percurso histórico cristaliza práticas oficiais restritivas a direitos, o que pode comprometer o paradigma humanista da nova Lei de Migração.
O MAPA DO FEMINICÍDIO NA POLÍCIA CIVIL DO PIAUÍ: UMA ANÁLISE ORGANIZACIONAL-SISTÊMICA
Authors: Villa Eugênia Nogueira do Rêgo Monteiro , Machado Bruno Amaral 
Published: March 2018

O estudo insere-se no campo da violência contra a mulher, na perspectiva do assassinato de mulheres por razões de gênero. A partir de inferências extraídas de bancos de dados oficiais da Polícia Civil do Piauí e análise de inquéritos policiais que apuraram feminicídio, elabora-se um mapa do feminicídio no Estado do Piauí, tomando-se por base as mesmas categorias eleitas por Waiselfisz no Mapa da Violência 2015 – Homicídio de mulheres no Brasil como paradigma de análise dos dados. A pesquisa é pioneira porque constitui o primeiro mapa após a vigência da Lei nº. 13.104/15 que instituiu o feminicídio no Brasil. O estudo detecta lacunas no tipo penal que dificultam a aplicação da qualificadora feminicídio sobre o que se poderia entender por matar uma mulher “por razões da condição do sexo feminino”. Para compreender como essa lacuna vem sendo superada no âmbito da cultura organizacional policial, o estudo analisa o conteúdo de 27 de um total de 50 inquéritos policiais de feminicídios consumados produzidos no período de 10. 3.15 a 30. 8.16. Foram eleitos como objeto de análise: laudos periciais, termos de oitivas, auto de prisão em flagrante delito, interrogatório e relatório. Em seguida, a pesquisa, orientada pela análise do discurso e pela abordagem organizacional, mapeia categorias empíricas neles presentes para adentrar na rotina policial e verificar como as organizações observam o feminicídio e de que modo se comunicam (decidem).
Hazard and risk assessment strategies for nanoparticle exposures: how far have we come in the past 10 years?
Authors: Warheit David B 
Published: March 2018

Nanotechnology is an emerging, cross-disciplinary technology designed to create and synthesize new materials at the nanoscale (generally defined as a particle size range of ≤10-9 meters) to generate innovative or altered material properties. The particle properties can be modified to promote different and more flexible applications, resulting in consumer benefits, particularly in medical, cosmetic, and industrial applications. As this applied science matures and flourishes, concerns have arisen regarding potential health effects of exposures to untested materials, as many newly developed products have not been adequately evaluated. Indeed, it is necessary to ensure that societal and commercial advantages are not outweighed by potential human health or environmental disadvantages. Therefore, a variety of international planning activities or research efforts have been proposed or implemented, particularly in the European Union and United States, with the expectation that significant advances will be made in understanding potential hazards related to exposures in the occupational and/or consumer environments. One of the first conclusions reached regarding hazardous effects of nanoparticles stemmed from the findings of early pulmonary toxicology studies, suggesting that lung exposures to ultrafine particles were more toxic than those to larger, fine-sized particles of similar chemistry. This review documents some of the conceptual planning efforts, implementation strategies/activities, and research accomplishments over the past 10 years or so. It also highlights (in this author’s opinion) some shortcomings in the research efforts and accomplishments over the same duration. In general, much progress has been made in developing and implementing environmental, health, and safety research-based protocols for addressing nanosafety issues. However, challenges remain in adequately investigating health effects given 1) many different nanomaterial types, 2) various potential routes of exposure, 3) nanomaterial characterization issues, 4) limitations in research methodologies, such as time-course and dose-response issues, and 5) inadequate in vitro methodologies for in vivo standardized, guideline toxicity testing.
Case Report: Clinically amyopathic dermatomyositis presenting acutely with isolated facial edema
Authors: Pappa Efthymia , Gkeka Marina , Protogerou Asimina , Marinos Leonidas , Loupa Chariclia , Christopoulos Constantinos 
Published: March 2018

A 45-year-old Asian man presented with acute-onset periorbital and facial edema associated with pyrexia. Muscle weakness was absent. Initial laboratory investigations showed an inflammatory reaction, while screening for infections was negative. Serum muscle enzyme levels were normal. He was hospitalized and treated empirically with antibiotics and corticosteroids, pending the result of facial skin and muscle biopsy. He showed a good clinical and laboratory response but an attempt to discontinue corticosteroids led to a prompt relapse of facial edema and pyrexia, associated with rising laboratory indices of inflammation. Biopsy findings were typical of dermatomyositis. Reintroduction of corticosteroid treatment resulted in complete clinical and laboratory remission. Facial edema as the sole clinical manifestation of dermatomyositis is extremely rare. There have been no previous reports of isolated facial edema in the setting of acute, clinically amyopathic dermatomyositis in adults. A high level of suspicion is required to make the diagnosis in the absence of myopathy and the hallmark cutaneous manifestations of the disease (heliotrope rash, Gottron papules).
Doktryna władzy monarszej Jakuba VI (I) Stuarta
Authors: Tulejski Tomasz 
Published: March 2018

James I Stuart’s theory of the divine right of kings
The author presents King James I Stuart’s theory of the divine right of kings as the modification of Bodin’s concept of the sovereignty. According to King James, a monarch is subjected to no earthly authority, as he derives his right to rule directly from the will of God. The king is thus not a subject to the will of his people, the aristocracy, or any other estate of the realm, including the Church. This doctrine implies that any attempt to depose a king or to restrict his power is contrary to the will of God and may constitute treason. The author argues, that the theory of the divine right of kings is rooted in the medieval idea that God had bestowed earthly power to the king, just as He had given spiritual power and authority to the Church, centering on a pope and in this way in protestant kingdoms may justifies the king’s absolute authority in both political and spiritual matters. The author points out that it is contrary to Bodin’s theory of sovereignty and he argues that King James’ general statements of divine right should not be read as claims about specific royal powers in any particular kingdom. Unlike the theorists of absolutism, King James thus believed the king to be bound to exercise his authority through defined constitutional channels. Such a requirement went beyond that expected of the absolute monarch, who was to rule well if he were to avoid the charge of tyranny. Finally the author argues, that King James’ theory of power is the attempt of the restoration of Christian uniformity and of the re‑Christianization of Bodin’s concept of the sovereignty.