bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metode Penyembuhan Penderita Skizofrenia oleh Mantri dalam Perspektif Pekerjaan Sosial
Authors: - Pairan , Mubarok Akhmad Munif , Nugraha Ekananda Novianta 
Published: December 2018

Abstract. This research aimed to know the mantri’s healing methods of schizophrenia patients in social work perspective in Andongsari Hamlet of Tugusari Village. The research problem was how the effort of professional nurse in the healing process of schizophrenia patients. The limited cost for treatment and creating negative stigma of public about schizophrenia made schizophrenia patients undergo the unfeasible treatment. With the existence of this professional nurse effort could help lighten up the families and schizophrenia patients in the healing process of schizophrenia. This research used qualitative research method with case study research type. The research location was conducted in Andongsari Hamlet, Tugusari Village, Bangsalsari Sub-district, Jember Regency. The research result was the professional nurse could help patients of schizophrenia in the healing process by utilizing the source system as support in the healing effort of schizophrenia patients. The treatment method that was done by the nurse to the schizophrenia patients through therapic medical, by providing medical medicine to make reimprovement of social function of that schizophrenia patients. Therapic stages of social function through a series activities: (a) family understanding of cognitive disability. (b) introduction of schizophrenia to environment; (c) digging the potency of the schizophrenia patients. Abstrak. Penelitian ini ditujukan untuk memahami pengobatan mantri pada pasien penderita skizofrenia dalam perspektif kerja sosial di Dusun Kecil Andongsari, Desa Tugusari. Masalah penelitian ini adalah bagaimana upaya perawatan profesional dalam proses pengobatan atas pasien penderita skizofrenia. Terbatasnya penghargaan perlakuan dan penciptaan stigma negatif publik pada skizofrenia dapat membuat pasien penderita skizofrenia mengalami perlakuan yang tidak layak. Dengan upaya perawatan secara profesional ini dapat membantu mengurangi kekhawatiran keluarga dan pasien penderita skizofrenia dalam proses pengobatan skizofrenia. Penelitian ini menggunakan metode penelitian kualitatif dengan tipe studi kasus. Lokasi penelitian dilakukan di Dusun Andongsari, Desa Tugasari, Kecamatan Bangsalsari, Kabupaten Jember. Hasil penelitian ini adalah perawatan profesional dapat membantu pasien skizofrenia dalam proses penyembuhannya dengan menggunakan sistem sumber daya sebagai dukungan dalam upaya penyembuhan pasien skizofrenia. Metode perlakuan yang dilakukan dalam pengobatan atas penderita skizofrenia ini melalui terapi medis yakni dengan menyediakan obat medis untuk mengembalikan keberfungsian sosial dari pasien penderita skizofrenia. Tahapan terapi fungsi sosial melewati beberapa aktifitas: (a) pemahaman keluarga atas disabilitas kognitif; (b) pengenalan skizofrenia pada lingkungan; (c) penggalian potensi penderita skizofrenia.
Father-Son Communication About Consistent and Correct Condom Use
Authors: Guilamo-Ramos Vincent , Thimm-Kaiser Marco , Benzekri Adam , Rodriguez Christopher , Fuller Taleria R. , Warner Lee , Koumans Emilia H.A. 
Published: December 2018

OBJECTIVES:
With this study, we explore communication about consistent and correct condom use among African American and Latino male adolescents ages 15 to 19 and their fathers.

METHODS:
Twenty-five father-son dyads completed semistructured interviews designed to elicit specific preferences for teaching and learning about consistent and correct condom use and strategies for addressing common condom use errors and problems. For analysis, we used in vivo coding and vertical and horizontal analysis techniques.

RESULTS:
Fathers and sons agreed that communication about condom use is feasible and acceptable. However, fathers tended to convey vague messages regarding protecting oneself from the negative consequences of sexual activity. Furthermore, both fathers and sons reported barriers hindering conversations. Secondly, the style and frequency of condom use conversations can help overcome barriers and support father-son relationship management. Talking frequently in 1-on-1 settings and using strategies to reduce discomfort made communication easier. Lastly, fathers and sons reported distinct preferences for teaching and learning about condom use. Sons wanted fathers to give specific guidance on the use and management of condoms. Fathers expressed interest in opportunities for improving their own condom knowledge and skills. Fathers identified gaps in their own condom use knowledge as a limitation to effective instruction of their sons.

CONCLUSIONS:
A father-focused communication intervention about condom use is feasible and acceptable. Enhancing the intergenerational benefits of father-son communication by addressing specific father-son preferences and learning needs for condom use instruction, as well as communication barriers, represents a novel mechanism for reducing male sexual reproductive health disparities.
Пищевая специализация шмелей (Hymenoptera: Apidae, Bombus Latreille) Среднеобской низменности
Authors: Demidova A. T. , Tyumaseva Z. I. , Guskova E. V. 
Published: December 2018

<p>For 14 species of bumblebees, <em>Bombus distinguendus, B. hortorum, B. consobrinus, B. muscorum, B. pascuorum, B. schrencki, B. bohemicus, B. hypnorum, B. pratorum, B. jonellus, B. sporadicus, B. lucorum, B. sichelii </em>and<em> B. semenoviellus </em>in the conditions of Sredneobsky lowlands, we have revealed trophic connections with 83 species of metasperms belonging to 68 genera of 25 families.</p><p> </p>
Betegpreferenciák az egészségügyi célú internethasználatban
Authors: Varga Zsuzsa , Horváth Tamás 
Published: December 2018

Abstract: Introduction: More sophisticated implementation of the Internet in healthcare improves medical services innumerably. To better understand the patients’ preferences for health-related use of Internet is warranted. Aim: Our aim was to determine the patients’ health-related Internet use. Method: Patients attending our private clinic between October 2016 and April 2017 were surveyed. Results: 208 questionnaires have been evaluated. Most patients use Internet daily, primarily on mobiles. The majority have already searched for health-related information online, 19% do regularly. 53% are satisfied with online contents and open to websites recommended by physicians. 32% of patients have already communicated with doctors online and 93% are satisfied doing so. 8% of patients use health-related smartphone applications regularly, 6% use other Internet-based health-monitoring devices. 60% of patients have already chosen a physician based on web information, while 17% do regularly. 82% of respondents have not yet shared health-related information on the Internet. Conclusions: The Internet is widely used by patients seeking information about their health, yet they are dissatisfied with the quality. Many patients are open to recommendations offered by physicians regarding sources of online information. Online communication between physician and patient might increase patient satisfaction. There is no breakthrough in the use of health-related websites, mobile apps or devices in Hungary. The demand for such service could be considered moderate. Additionally, online patient forums are not specifically popular. The medical society in Hungary should accept that physician selection by patients depends more increasingly upon information made available online. Orv Hetil. 2018; 159(51): 2175–2182.
Fogászati sérülésekről készült látleletek komplex terminológiai, fogászati és igazságügyi orvosszakértői elemzése
Authors: Bán Ágnes , Patonai Zoltán , Fogarasi Katalin , Schneider Philipp , Boda Róbert , Gergely Péter 
Published: December 2018

Abstract: Writing a constat is a professional skill required of every general physician and dentist. Constats are issued by healthcare providers on the investigating authority’s, court’s or injured person’s request. This document is an official judicial evidence, a record of medical examination, and it is also a medical opinion which can determine the outcome of the subsequent legal process. Incomplete and incorrect injury descriptions make it difficult for forensic experts to form accurate and appropriate opinions. The authors examined 147 dental and oral surgical constats from the Universities of Pécs and Debrecen using multidisciplinary approach (according to terminological, dental, surgical, forensic and criminal legal aspects). Several medical reports contained mistakes in terms of inaccuracies and self-contradictions, terminology and professional medical practice. The documents included 352 injuries (11.1% of which were tooth injuries, 47.7% bone injuries and 41.2% soft-tissue injuries). The low number of attributes per injury (0.64 on average) indicates insufficient documentation. As a result of the comparative analysis, significant differences were found between the documentation of dental injuries and that of other bone injuries pertaining to their information content. We can state that physicians are most consistent when describing bone injuries, while they are less articulate about tooth injuries. The authors provide an overview of the legal consequences of injuries as well as the legal practice regarding tooth injuries in Germany and Austria, and recommend the creation of a nationwide, unified terminology for both dental and trauma departments on nasal and dental injuries. Orv Hetil. 2018; 159(51): 2154–2161.
Az ischaemiás eredetű balkamra-aneurysma sebészi rekonstrukciója. Két sebészi technika korai és középtávú eredményei
Authors: Balau Radu , Deac Radu , Kovacs Judit , Harpa Marius , Ghiragosian Claudiu , Al Hussein Hussam , Suciu Horatiu 
Published: December 2018

Abstract: Introduction: Left ventricular aneurysm is a severe complication of acute myocardial infarction, which contributes significantly to mortality and morbidity associated with this pathology. Despite the progress of correction techniques, there are still controversies about the optimal approach addressing this pathology. Aim: The aim of this study was to analyse short and medium term outcomes of left ventricular reconstruction for ischemic left ventricular aneurysm using two surgical techniques (endoventricular patch plasty and liniar suture) in order to determine if one of these techniques has supperior results. Method: 117 patients were included in the study, 48 patients (41%) underwent left ventricular reconstruction with endoventricular patch (Group 1), 69 patients (59%; Group 2) had linear reconstruction. 113 patients (96.5%) required associated procedures: 108 surgical myocardial revascularization, 18 mitral valvuloplasty and 8 ventricular septal defect closure. Short and medium term morbidity, mortality, alteration of ejection fraction and NYHA class were analysed. Results: Perioperative mortality was 11.11%, 4.2% in the endoventricular patch group, and 15.9% in the linear suture group (p = 0.03). The overall 5-year survival was 78.5% (88.7% in Group 1 and 71.2% in Group 2). The left ventricular ejection fraction and NYHA functional class improved in both groups, with greater improvement in the endoventricular patch group. Conclusions: Surgical ventricular reconstruction is a procedure performed for the correction of ischemic left ventricular aneurysm with good early and medium-term results, but with better results with the endoventricular patch technique regarding early and medium-term mortality, ejection fraction and NYHA functional class improvement. Orv Hetil. 2018; 159(51): 2167–2174.
Brand Personality Model of Chain Drug Stores in Chile
Authors: Escobar-Farfán Manuel , Gallargo Rodrigo 
Published: December 2018

La siguiente investigación propone un modelo de personalidad de marca que se origina de la validez estructural del modelo teórico denominado “Pharmacy Chains Brand Personality”. El modelo desarrollado ha sido elaborado mediante un diseño metodológico compuesto por una validez estructural exploratoria y confirmaría con adecuados índices de ajuste y confiabilidad. Si bien ha sido considerado el modelo de Aaker (1997) de referencia al tener un reconocimiento y validez por la literatura, este estudio se ha adaptado al contexto de las cadenas de farmacias en Chile. Esta investigación es de carácter exploratorio de tipo cuantitativa y con la aplicación de cuestionaros estructurados compuestos por una escala Likert de 5 niveles para identificar el grado de acuerdo de los 30 rasgos de personalidad que fueron propuestos para la industria (Escobar-Farfán et al., 2017). Es relevante la aplicación de personalidad de marca en la industria de las cadenas de farmacia debido a la importancia de la industria en la sociedad, como también la elaboración de nuevas estrategias comerciales que se adapten a las necesidades y apreciaciones de los consumidores ante la industria farmacéutica. La técnica aplicada ha sido un análisis factorial, los cuales arrojaron la validez de 14 rasgos de personalidad agrupados en dos dimensiones de personalidad; transparencia y ambición. Este documento contribuye a la literatura de marca y conducta del consumidor, ya que entrega los patrones que reconocen los clientes de las farmacias, lo que permite la elaboración de futuras investigaciones para analizar el comportamiento y decisión de compra del consumidor, la cual fue afectada por el descubrimiento de colusión de la industria en Chile.Palabras claves: Personalidad de marca, Farmacias, Rasgos de Personalidad, Chile, marca.
ROLE OF TUMOR NECROSIS FACTOR ALPHA IN IMMUNE PATHOGENESIS OF DIFFERENT DISEASES AND ITS SIGNIFICANCE FOR EVOLVING ANTICYTOKINE THERAPY WITH MONOCLONAL ANTIBODIES
Authors: Voronina E. V. , Lobanova N. V. , Yakhin I. R. , Romanova N. A. , Seregin Yu. A. 
Published: December 2018

Tumor necrosis factor alpha (generally known as cachectin) was noted as a hallmark since the time of its discovery and still retains its position as one of the most intensely studied molecules in the field of biomedicine. TNFα is considered a prototype molecule of the family which, on the one hand, plays an important role in regulating normal differentiation, growth and metabolism of various cells, and on the other hand, acts as mediator of inflammatory processes in various human diseases. Intensive interdisciplinary studies of TNFα biological role and therapeutic use have led to understanding of its polyfunctional effects and establishment of its leading role in immune pathogenesis of diseases, which was the basis for the development of “anticytokine” therapy with highly specific monoclonal antibodies. We aimed for a search of literature in the field of studying TNFα structure and properties, its role under normal conditions, in different diseases and therapy. The literature studies were performed using scientific searching systems and databases. The results are as follows: the role of tumor necrosis factor-α (TNFα) in human body in normal and pathological state was considered. Possible TNF-inducible signaling pathways, as well as existing inhibitors based on monoclonal antibodies for the treatment of rheumatoid arthritis and other autoimmune diseases are described. In conclusion, intensive interdisciplinary studies of TNFα biological functions in normal state and diseases are still relevant today, despite huge knowledge gained on this subject.Undisputable progress in understanding the functional multiplicity of TNFα as a participant in regulation of various physiological and pathological processes in the human body has promoted development of biological agents, i.e., the tumor necrosis factor inhibitors based on monoclonal antibodies, which proved to be highly effective drugs for treatment of rheumatoid arthritis and other diseases, thus being effective and safe biopharmaceuticals.
TECHNICAL ASPECTS OF EVALUATING CYTOKINE PROFILE AND LEUKOCYTE REACTION IN BILE DUCT OBTURATION OF DIFFERENT ORIGIN
Authors: Karpunina T. I. , Godovalov A. P. , Busyrev Yu. B. 
Published: December 2018

The study was carried out to assess the prospects for the combined use of leukocyte and cytokine indices in the bile duct obstruction of different genesis.We have performed a study of the patients with mechanical jaundice, either due to tumor (14 persons), or non-tumor genesis (16 persons). Concentrations of cytokines (IL-1, IL-4, IL-8, TNFα) were determined in blood serum before surgical intervention. The total activity of endogenous inflammatory mediators in the serum of patients was estimated as an index of inflammatory activity (IVA), which was calculated using the following formula: IVA = (IL-1 + TNFα)/IL-4. In addition, a number of leukocyte indices were calculated. The cellular component in the index estimation makes it possible to clarify the intensity of the inflammatory reaction, and to suggest the direction of the functional changes among the immunocompetent cells.It was shown that IVA in presence of malignancy is significantly higher than in benign conditions. Overactivation of immune response in tumors may be caused by a significant predominance of pro-nflammatory cytokines. Moreover, in cases of malignant tumor growth, both with or without cholangitis, the index scores of humoral and cellular components let us suggest the some problems with regeneration, due to pro-inflammatory domination of immune response, which does not ensure activation of the corresponding reactions. It has been established that the leukocyte intoxication index (LII) is increased,in patients with a combination of malignant disorder and cholangitis, and the immunoreactivity index (MDI) is lowered. In absence of cholangitis, the opposite pattern is observed, when LII is slightly lowered and MDI is elevated. Correlation analysis for the patients with cholangitis revealed a high association of cytokine imbalance and endogenous intoxication. A complex of cytokine and leukocyte indices is promising, when each of them reflects a certain part of the process, and their combination gives an integral picture of the pathology and allows to predict development of the disease. Such an approach, seems to increase the diagnostic significance of these immunological indices, primarily, the cytokine production, and may be used when predicting currence of complications in the surgical treatment of the disease.
DIFFERENTIATED EFFECTS OF GLUCOSAMINYLMURAMILDIPEPTIDE ON THE NONTRANSFORMED AND EXPERIMENTALLY TRANSFORMED PHENOTYPE OF CD62L+CD63+CD66d+ NEUTROPHILIC GRANULOCYTES IN CONVENTIONALLY HEALTHY PEOPLE
Authors: Nesterova I. V. , Malinovskaya V. V. , Khaydukov S. V. , Nguyen Thi D. L. , Chudilova G. A. , Lomtatidze L. V. 
Published: December 2018

Modern studies have shown a high plasticity and phenotypic diversity of neutrophilic granulocytes (NG) provided by different receptors, which are diagnostic markers for the functional capacity of the cell in the course of their activities. We investigated NG from peripheral blood, obtained from healthy people of both sexes aged from 26 to 66 years. Evaluation of the neutrophil membrane receptor expression was carried out by flow cytometry. The relative amount of neutrophilic granulocytes expressing membrane CD62L, CD63, CD66d receptors and the intensity of their expression were determined according to their fluorescence intensities. The surface NG membrane receptors, i.e., CD62L, CD63, CD66d were studied upon the in vitro experimental influence of the following bacterial peptides: N-formyl-methionyl-leucyl-phenylalanine (FMLP, model 1); glucosaminylmuramyldipeptide (GMDP, model 2), and simultaneous incubation of NG blood with fMLP and GMDP (model 3). The in vitro treatment with fMLP in the in vitro model was used to transform the NG phenotype of conventionally healthy subjects, expressing CD62, CD63, CD66d molecules. The treatment caused a significantly decrease in both CD62L and the CD62L expression in relative amounts of neutrophilic granulocytes with a parallel increase of CD63 expression density. The effect of GMDP on the NG phenotype of conditionally healthy subjects did not change the amount of CD62L+NG and CD63+NG, and did not affect CD62L and CD63 expression density on the surface of NG. However, the amount of CD66d+NG was significantly increased with the unchanged expression of CD66d molecules. GMDP introduced together with the bacterial fMLP peptide was shown to neutralize some features of the NG phenotype transformation caused by fMLP, i.e., the amount of CD62L+ NG was restored by 22 % and the CD62L expression density increased significantly. At the same time, GMDP did not correct the negative effect of fMLP upon the number of CD63+NG and CD66d+NG, and on the CD63 and CD66d expression. Simultaneous addition of fMLP and GMDP did significantly increase the amount of CD66d+NG and expression density of CD63 molecules on the CD63+NG membrane as compared to intact NG of conditionally healthy subjects. The obtained data are important in order to justify some new immunotherapeutic strategies aimed at correction of the negatively transformed NG phenotype, which accompanies some infectious and inflammatory diseases of bacterial etiology with atypical clinical course.
ASSOCIATION OF MATRIX METALLOPROTEINASES GENE POLYMORPHISM WITH CLINICAL MANIFESTATIONS OF BRONCHIAL ASTHMA IN CHILDREN
Authors: Lebedenko A. A. , Shkurat T. P. , Mashkina E. V. , Semernik O. E. , Dreyzina T. K. , Tyurina E. B. 
Published: December 2018

In the present study, we have examined association between different polymorphic variants of metalloproteinases genes and clinical manifestations of bronchial asthma in children. We observed 103 patients including 42 children with an established diagnosis of asthma. Moreover, 61 persons were examined in the control group. All patients underwent genetic testing by allele-specific polymerase chain reaction. In particular, 320A>C polymorphic locus of ММР20 gene; Val275Ala ММР20, and -8202A>G gene ММР9 were analyzed.We have found that 30 patients (71.4% of total) had bronchial asthma of mild severity, 9 children (21.4%) exhibited moderate degree, and 3 patients (7%) had severe-grade disease. Homozygous C/C variant of the polymorphic ММР20 gene, 320A>C heterozygous variant of the ММР20 Val275Ala polymorphism, and heterozygous locus of -8202A>G ММР9 gene were found to be most frequent among the children with asthma. Generally, we have observed that the frequencies of the studied alleles and genotypes did not significantly differ berween the asthma patients and children from the control group (p < 0.05). However, in patients with GGgenotype of -8202A>G ММР9 polymorphism combined with homozygosity for the C allele of ММР20 320A>C, a more severe disease was observed, being combined with polyvalent sensitization and high total IgE levels in blood serum.In conclusion, frequencies of alleles and genotypes among patients with asthma did not show any statistically significant differences from the group of healthy children. The patients homozygous for G allele of ММР9 -8202A>G polymorphism gene and for the C allele ММР20 gene (320A>C) seem to be predisposed for a more severe clinical course of the disease.