bluuebunny/crossref_metadata_2025_split huggingface dataset:
The State of Oncology Practice in America, 2018: Results of the ASCO Practice Census Survey
Authors: Kirkwood M. Kelsey , Hanley Amy , Bruinooge Suanna S. , Garrett-Mayer Elizabeth , Levit Laura A. , Schenkel Caroline , Seid Jerome E. , Polite Blase N. , Schilsky Richard L. 
Published: June 2018

[Media: see text] Purpose: To describe the US hematology and medical oncology practice landscape and to report findings of the sixth annual ASCO Oncology Practice Census survey. Participants and Methods: ASCO used Medicare Physician Compare data to characterize oncology practices in the United States. Practice size, number of care sites, and geographic distribution were determined. Trends in the number and size of practices from 2013 to 2017 were examined. All US oncology practices were targeted for the survey; survey responses were linked to the practices identified from Physician Compare to augment results and assess generalizability. Results: More than 2,200 hematology/oncology practices provided care to adult patients in 2017. We observed annual decreases in the number of practices and annual increases in practice size. Of the 2017 practices, 394 (18%) completed the survey and accounted for 58% of the US hematologist/oncologist workforce (n = 7,203). Respondents tended to be larger and encompass more sites of care than nonrespondents. Surveyed practices cited payers (58%), competition (38%), and staffing (37%) as primary sources of strain. Prior authorization was dominant among payer pressures (78%). Electronic health records remained a burden on practices, with only 15% reporting full interoperability. Conclusion: The results of ASCO’s 2017 survey indicate that oncology practices are challenged by day-to-day operations, often related to payment, reimbursement, and competition. Our findings likely represent conservative estimates of such burdens because they are driven by responses from midsized to large-sized organizations, which have lower relative administrative burden, greater market influence, and potentially better ability to adapt in a changing health care environment.
Integrin activity in neuronal connectivity
Authors: Lilja Johanna , Ivaska Johanna 
Published: June 2018

ABSTRACT
The formation of correct synaptic structures and neuronal connections is paramount for normal brain development and a functioning adult brain. The integrin family of cell adhesion receptors and their ligands play essential roles in the control of several processes regulating neuronal connectivity – including neurite outgrowth, the formation and maintenance of synapses, and synaptic plasticity – that are affected in neurodevelopmental disorders, such as autism spectrum disorders (ASDs) and schizophrenia. Many ASD- and schizophrenia-associated genes are linked to alterations in the genetic code of integrins and associated signalling pathways. In non-neuronal cells, crosstalk between integrin-mediated adhesions and the actin cytoskeleton, and the regulation of integrin activity (affinity for extracellular ligands) are widely studied in healthy and pathological settings. In contrast, the roles of integrin-linked pathways in the central nervous system remains less well defined. In this Review, we will provide an overview of the known pathways that are regulated by integrin–ECM interaction in developing neurons and in adult brain. We will also describe recent advances in the identification of mechanisms that regulate integrin activity in neurons, and highlight the interesting emerging links between integrins and neurodevelopment.
Overexpression of PP1–NIPP1 limits the capacity of cells to repair DNA double-strand breaks
Authors: Winkler Claudia , Rouget Raphael , Wu Dan , Beullens Monique , Van Eynde Aleyde , Bollen Mathieu 
Published: June 2018

ABSTRACT
The ubiquitously expressed nuclear protein NIPP1 (also known as PPP1R8) recruits phosphoproteins for regulated dephosphorylation by the associated protein phosphatase PP1. To bypass the PP1 titration artifacts seen upon NIPP1 overexpression, we have engineered covalently linked fusions of PP1 and NIPP1, and demonstrate their potential to selectively explore the function of the PP1:NIPP1 holoenzyme. By using inducible stable cell lines, we show that PP1–NIPP1 fusions cause replication stress in a manner that requires both PP1 activity and substrate recruitment via the ForkHead Associated domain of NIPP1. More specifically, PP1–NIPP1 expression resulted in the build up of RNA–DNA hybrids (R-loops), enhanced chromatin compaction and a diminished repair of DNA double-strand breaks (DSBs), culminating in the accumulation of DSBs. These effects were associated with a reduced expression of DNA damage signaling and repair proteins. Our data disclose a key role for dephosphorylation of PP1:NIPP1 substrates in setting the threshold for DNA repair, and indicate that activators of this phosphatase hold therapeutic potential as sensitizers for DNA-damaging agents.
Online MAP Enforcement: Evidence from a Quasi-Experiment
Authors: Israeli Ayelet 
Published: June 2018

This paper investigates a manufacturer’s ability to influence compliance rates among its authorized online retailers by exploiting changes in the minimum advertised price (MAP) policy and in dealer agreements. MAP is a pricing policy widely used by manufacturers to influence prices set by their downstream partners. A MAP policy imposes a lower bound on advertised prices, subjecting violating retailers to punishments such as termination of distribution agreements. Despite this threat, violations are common. I uncover two key elements to improve compliance: customization to the online environment and credible monitoring and punishments. I analyze the pricing, enforcement, and channel management policies of a manufacturer over several years. During this period, new channel policies take effect, providing a quasi-experiment. The new policies lead to substantially fewer violations. With improved compliance, channel prices increase by 2% without loss in volume. The reduction in violations is particularly stark among authorized retailers with lower sales volume, those that previously operated unapproved websites, and those that have received violation notifications for the specific product before. Moreover, low service providers improve their service. At the same time, there is an increase in opportunistic behavior among top retailers, or retailers that received notifications for other products, and for less popular products via deep discounting. Data and the online appendix are available at https://doi.org/10.1287/mksc.2018.1092 .
The Heimdall framework for supporting characterisation of learning health systems
Authors: McLachlan Scott , Potts Henry W. W. , Dube Kudakwashe , Buchanan Derek , Lean Stephen , Gallagher Thomas , Johnson Owen , Daley Bridget , Marsh William , Fenton Norman 
Published: June 2018

BackgroundThere are many proposed benefits of using learning health systems (LHSs), including improved patient outcomes. There has been little adoption of LHS in practice due to challenges and barriers that limit adoption of new data-driven technologies in healthcare. We have identified a more fundamental explanation: the majority of developments in LHS are not identified as LHS. The absence of a unifying namespace and framework brings a lack of consistency in how LHS is identified and classified. As a result, the LHS ‘community’ is fragmented, with groups working on similar systems being unaware of each other’s work. This leads to duplication and the lack of a critical mass of researchers necessary to address barriers to adoption.ObjectiveTo find a way to support easy identification and classification of research works within the domain of LHS.MethodA qualitative meta-narrative study focusing on works that self-identified as LHS was used for two purposes. First, to find existing standard definitions and frameworks using these to create a new unifying framework. Second, seeking whether it was possible to classify those LHS solutions within the new framework.ResultsThe study found that with apparently limited awareness, all current LHS works fall within nine primary archetypes. These findings were used to develop a unifying framework for LHS to classify works as LHS, and reduce diversity and fragmentation within the domain.ConclusionsOur finding brings clarification where there has been limited awareness for LHS among researchers. We believe our framework is simple and may help researchers to classify works in the LHS domain. This framework may enable realisation of the critical mass necessary to bring more substantial collaboration and funding to LHS. Ongoing research will seek to establish the framework’s effect on the LHS domain.
Effect of clinical pathway regarding promoting quality nursing care of patients with myocardial infarction exposed to invasive procedures
Authors: ELsayed Shrief Sheren , Abdelnaby Hamed Laila 
Published: June 2018

Myocardial infarction is theÂ deathÂ of myocardial tissueÂ because ofÂ extendedÂ lack ofÂ blood and oxygen. Clinical pathway has emerged as one of the mostÂ famous new initiatives alleged to lower costs whilst maintaining or even improving the satisfactoryÂ level ofÂ patientÂ care.Aim: to assess the effect of clinical pathway regarding promoting quality Nursing care of patients with MI exposed to invasive procedures through designing, Implementing, and evaluating the effect of clinical pathway intervention.Design: A quasi-experimental research design (pre posttest) changed intoÂ applied in this study.Setting: The study has been carried out in Beni-suef university Hospital, Zagazig University Hospitals.Sample: thirty nurses from the previously mentioned setting and thirty patients with myocardial infarction who are hospitalized and exposed to invasive procedures.Tools: Assessment questionnaire (pre/post test) sheet, An Observational Checklist, and Hamilton Anxiety Rating Scale (HAM-A).Results: more than fifty percent of a studied sample of nurses their ages ranged from 20-30yrs, the mean age was (29.1Â±3.4), females (66.9%), and have beenÂ trainedÂ in nursing college, their work experience ranged from half to one decade. There has been a statistically significant distinction concerning knowledge and practical abilities of studied nurses among pre and post application of clinical pathway. Recommendations: Extra new studies should be done for better assessment of the nurse's abilities and distribute educational booklets, pamphlets, and posters to all nurses with a purpose toÂ enhanceÂ theirÂ degreeÂ ofÂ knowledgeÂ andÂ skills.Â Â Â Keywords: Clinical Pathway, Quality Nursing Care, patients, and Myocardial Infarction.
Regularity results for p-Laplacians in pre-fractal domains
Authors: Capitanelli Raffaela , Fragapane Salvatore , Vivaldi Maria Agostina 
Published: June 2018

Abstract
We study obstacle problems involving p-Laplace-type operators in non-convex polygons.
We establish regularity results in terms of weighted Sobolev spaces. As applications, we obtain estimates for the FEM approximation for obstacle problems in pre-fractal Koch Islands.
Combined international external quality assessment results of medical laboratory performance and reporting of samples with known antimicrobial resistance
Authors: Noble Michael A. , Rennie Robert 
Published: June 2018

Abstract

Background
Reporting on the presence of antimicrobial resistance is of considerable concern both for individual patient care and for understanding the underlying health status within the community at large. Antimicrobial resistance is solely dependent upon clinical laboratory detection and thus can be impacted upon by the quality and competence of medical laboratories. Proficiency testing or external quality assessment (PT/EQA) is the international standard for the direct measurement of medical laboratory performance on critical testing.

Methods
An international, intercontinental collaborative retrospective study of medical laboratory performance in antibiotic resistance was performed by the Microbiology Working Group (MWG) of the European Organisation for External Quality Assurance for Laboratory Medicine (EQALM) with particular examination of laboratory performance on the testing and reporting of methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE) and carbapenem-resistant Enterobacteriaceae (CRE).

Results
The results of 1880 medical laboratories were compiled. Strictly accurate reporting of isolates as resistant occurred with MRSA 96.9%, with VRE 91.3% and with CRE 93.1% of the time. On the other hand, very major errors (reporting of false susceptibility) were observed with 2.2% of MRSA and 2.4% of VRE and 0.8% of CRE. Major errors (false resistance) were reported for vancomycin susceptibility testing for MRSA at a rate of 0.6%.

Conclusions
Depending on how clinical physicians read and understand microbiology susceptibility reports, proficient acceptable results were reported either between 91% and 94% of the time, or between 97% and 100%. While very major errors are infrequently reported, they were found in all regions and could potentially cause poor treatment decisions by clinicians. A collective analysis of multi-program PT/EQA information can provide valuable insights into the testing and reporting practices of medical laboratories.
Dielectric barrier discharge (DBD) plasma pretreatment of lignocellulosic materials in air at atmospheric pressure for their improved wettability: a literature review
Authors: Žigon Jure , Petrič Marko , Dahle Sebastian 
Published: June 2018

AbstractThe treatment of wood surfaces with gas discharges is one of the methods to achieve better surface adhesion properties. Good penetration, spreading and wettability of the applied liquid adhesives and coatings is a crucial factor for their adequate mechanical properties. Plasmas are the result of electrical discharge and can be created in different ways. The plasma treatment (PT) is frequently executed prior to material bonding or coating via the so-called dielectric barrier discharges (DBD) at atmospheric pressure. This literature review summarizes the essential aspects of DBD PTs aiming at a better wettability and surface adhesion. After introduction of the principle of DBD, the individual effects of internal and external parameters of the process will be discussed, which influence the final properties of treated materials.
Regulation of LRRK2: insights from structural and biochemical analysis
Authors: Gilsbach Bernd K. , Eckert Marita , Gloeckner Christian Johannes 
Published: June 2018

Abstract
Leucine-rich repeat kinase 2 (LRRK2) is a multi-domain protein and its mutations can lead to Parkinson’s disease. Recent studies on LRRK2 and homologue proteins have advanced our mechanistic understanding of LRRK2 regulation. Here, we summarize the available data on the biochemistry and structure of LRRK2 and postulate three possible layers of regulation, translocation, monomer-dimer equilibrium and intramolecular activation of domains.
Twitch or swim: towards the understanding of prokaryotic motion based on the type IV pilus blueprint
Authors: Daum Bertram , Gold Vicki 
Published: June 2018

Abstract
Bacteria and archaea are evolutionarily distinct prokaryotes that diverged from a common ancestor billions of years ago. However, both bacteria and archaea assemble long, helical protein filaments on their surface through a machinery that is conserved at its core. In both domains of life, the filaments are required for a diverse array of important cellular processes including cell motility, adhesion, communication and biofilm formation. In this review, we highlight the recent structures of both the type IV pilus machinery and the archaellum determined in situ. We describe the current level of functional understanding and discuss how this relates to the pressures facing bacteria and archaea throughout evolution.
Seasonal Body Composition Variation Amongst Elite European Professional Soccer Players: An Approach of Talent Identification
Authors: Owen Adam Lee , Lago-Peñas Carlos , Dunlop Gordon , Mehdi Rouissi , Chtara Moktar , Dellal Alexandre 
Published: June 2018

Abstract
The primary aim of the investigation was to study the seasonal changes in body composition in elite European soccer players and identify key playing positional differences. Twenty-two players (age = 24 ± 3.7 years, body height = 180.45 ± 5.12 cm, body mass = 76.66 ± 5.34 kg) were tested. Players’ mass (kg), lean body mass (LBM), fat free mass (FFM), fat mass (FM), muscle girths (MG) and sum of 8 skinfolds (mm) were measured across 5 time points (T0 = Start of pre-season training; T1 = End of pre-season training; T2 = Mid-season; T3 = End of mid-season break; T4 = End of season). Players were divided into their tactical positional roles for analysis. The specific positions they were divided into included defenders (n = 8), midfielders (n = 8) and forwards (n = 6). Assessment of training and matchplay exposure were also recorded. Sites-4, Sites-7, Sites-8 and Fat Mass decreased dramatically from T0 to T1 and T2 in all playing positions (p < 0.01), while no remarkable differences were found between T2, T3 and T4. Except for defenders, calf girth and lean mass were higher in T2, T3 and T4 compared to T0 and T1 (p < 0.01). Midfielders were found to be leaner than forwards and defenders in all data collection time point sessions. Defenders showed higher values in calf girth and lean body mass than midfielders and forwards. It can be concluded from this investigation that there are large variances n positional body composition profiles amongst professional European soccer players. Furthermore, significant changes are prevalent and occur across the season from LBM, FFM, MG and skinfold assessment amongst European elite level soccer players.
The Impact of Nonlinear Pedagogy on Decision-Making and Execution in Youth Soccer Players According to Game Actions
Authors: Práxedes Alba , Del Villar Fernando , Pizarro David , Moreno Alberto 
Published: June 2018

Abstract
The aim of this study was to analyze the effect of a teaching program, based on Non-Linear Pedagogy, on decision-making and performance in youth soccer players as a function of the type of play action. Our participants were 19 players from the U12 age category. The teaching program, which was based on the application of modified games characterized by a numerical superiority in attack, was used for 14 training sessions. This program was conducted in two phases (preparation-for-intervention and intervention). Decision-making and execution for pass and dribbling actions were evaluated through the Game Performance Evaluation Tool. The results showed significant differences in favour of the experimental group in decision-making (p < .000) and the execution of passes (p = .003) after the intervention. However, such differences were not found for dribbling (decision-making, p = .402 and execution, p = .143). These findings demonstrate the effectiveness of this type of program for teaching actions with a high tactical component, such as the pass, and a different approach must be considered in actions with a high technical component, such as dribbling. It is necessary to continue developing studies in this line to clarify these issues.
Correlation Between Match Performance and Field Tests in Professional Soccer Players
Authors: Redkva Paulo E. , Paes Mauro R. , Fernandez Ricardo , da-Silva Sergio G. 
Published: June 2018

Abstract
The aim of this study was to investigate possible correlations between aerobic and anaerobic fitness (in field tests) with performance during a 90 min friendly match, through the following variables: total distance covered, maximal running speed, number of high-intensity actions and number of sprints. Eighteen professional soccer players from a Brazilian elite team (age 23 ± 3 years, body mass 77.5 ± 8.9 kg) participated in the study. The athletes performed a Yo-Yo Endurance Test (aerobic fitness) and a Running Anaerobic Sprint Test (six maximal 35 m efforts separated by 10 s of passive recovery, anaerobic fitness). Data were collected during friendly matches using a GPS with 5 Hz technology. To establish the correlation between the variables determined during the matches, the Pearson correlation coefficient was used (significance level of p ≤ 0.05). A high correlation was found between distance covered in the Yo-Yo endurance test and total distance covered (r = 0.72; p < 0.05), number of high-intensity actions (r = 0.78; p < 0.05) and number of sprints (r = 0.88; p < 0.01) in the soccer matches. The RAST variables did not relate to the standards set during the matches (p < 0.05). From the results of the present study, it may be concluded that there is no correlation between RAST and friendly match data variables. However, better results in the Yo-Yo endurance test correlate with total distance, number of high-intensity actions and sprints during matches.
Cyclically presented groups with length four positive relators
Authors: Bogley William A. , Parker Forrest W. 
Published: June 2018

Abstract
We classify cyclically presented groups of the form

G
=

G
n

⁢

(

x
0

⁢

x
j

⁢

x
k

⁢

x
l

)

{G=G_{n}(x_{0}x_{j}x_{k}x_{l})}

for finiteness and, modulo two unresolved cases, we classify asphericity for the underlying presentations. We relate finiteness and asphericity to the dynamics of the shift action by the cyclic group of order n on the nonidentity elements of G and show that the fixed point subgroup of the shift is always finite.
Detectingde NovoHomoeologous Recombination Events in CultivatedBrassica napusUsing a Genome-Wide SNP Array
Authors: Higgins Erin E , Clarke Wayne E , Howell Elaine C , Armstrong Susan J , Parkin Isobel A P 
Published: June 2018

AbstractThe heavy selection pressure due to intensive breeding of Brassica napus has created a narrow gene pool, limiting the ability to produce improved varieties through crosses between B. napus cultivars. One mechanism that has contributed to the adaptation of important agronomic traits in the allotetraploid B. napus has been chromosomal rearrangements resulting from homoeologous recombination between the constituent A and C diploid genomes. Determining the rate and distribution of such events in natural B. napus will assist efforts to understand and potentially manipulate this phenomenon. The Brassica high-density 60K SNP array, which provides genome-wide coverage for assessment of recombination events, was used to assay 254 individuals derived from 11 diverse cultivated spring type B. napus. These analyses identified reciprocal allele gain and loss between the A and C genomes and allowed visualization of de novo homoeologous recombination events across the B. napus genome. The events ranged from loss/gain of 0.09 Mb to entire chromosomes, with almost 5% aneuploidy observed across all gametes. There was a bias toward sub-telomeric exchanges leading to genome homogenization at chromosome termini. The A genome replaced the C genome in 66% of events, and also featured more dominantly in gain of whole chromosomes. These analyses indicate de novo homoeologous recombination is a continuous source of variation in established Brassica napus and the rate of observed events appears to vary with genetic background. The Brassica 60K SNP array will be a useful tool in further study and manipulation of this phenomenon.