bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiR-126 Mediates Brain Endothelial Cell Exosome Treatment–Induced Neurorestorative Effects After Stroke in Type 2 Diabetes Mellitus Mice
Authors: Venkat Poornima , Cui Chengcheng , Chopp Michael , Zacharek Alex , Wang Fengjie , Landschoot-Ward Julie , Shen Yi , Chen Jieli 
Published: August 2019

Background and Purpose—
Stroke patients with type 2 diabetes mellitus (T2DM) exhibit increased vascular and white matter damage and have worse prognosis compared with nondiabetic stroke patients. We investigated the neurorestorative effects of exosomes derived from mouse brain endothelial cells (EC-Exo) as treatment for stroke in T2DM mice and investigated the role of miR-126 in mediating EC-Exo–derived therapeutic benefits in T2DM-stroke mice.

Methods—

Adult, male BKS.Cg-m+/+Lepr
db
/J (T2DM) mice were subjected to photothrombotic stroke model. T2DM mice were intravenously injected at 3 days after stroke with (1) PBS; (2) liposome mimic (vehicle control, 3×10
10
); (3) EC-Exo (3×10
10
); (4) knockdown of miR-126 in EC-Exo (miR-126
−
/−
EC-Exo, 3×10
10
). Behavioral and cognitive tests were performed, and mice were sacrificed at 28 days after stroke.

Results—

Compared with non-DM stroke mice, T2DM-stroke mice exhibit significantly decreased serum and brain tissue miR-126 expression. Endothelial cells and EC-Exo contain high levels of miR-126 compared with other cell types or exosomes derived from other types of cells, respectively (smooth muscle cells, astrocytes, and marrow stromal cells). Compared with PBS or liposome mimic treatment, EC-Exo treatment of T2DM-stroke mice significantly improves neurological and cognitive function, increases axon density, myelin density, vascular density, arterial diameter, as well as induces M2 macrophage polarization in the ischemic boundary zone. MiR-126
−/−
EC-Exo treatment significantly decreases miR-126 expression in serum and brain, as well as attentuates EC-Exo treatment–induced functional improvement and does not significantly increase axon and myelin density, vascular density, arterial diameter or induce M2 macrophage polarization in T2DM-stroke mice. In vitro, EC-Exo treatment significantly increases primary cortical neuron axonal outgrowth and increases endothelial capillary tube formation whereas miR-126
−/−
EC-Exo attentuates EC-Exo induced capillary tube formation and axonal outgrowth.

Conclusions—
EC-Exo treatment of stroke promotes neurorestorative effects in T2DM mice. MiR-126 may mediate EC-Exo–induced neurorestorative effects in T2DM mice.

Visual Overview—

An online
visual overview
is available for this article.
Was Samuel Meant to Be a Nazirite? The First Chapter of Samuel and the Paradigm Shift in Textual Study of the Hebrew Bible
Authors: Aejmelaeus Anneli 
Published: August 2019

Abstract
This article aims to demonstrate the urgency of new methodological thinking through the analysis of one biblical passage. The main focus is on the two passages that give expression to Hannah’s vow (1 Sam 1:11 and 22–23): Was it originally meant as a Nazirite vow on behalf of an unborn child? The analysis results in the identification of editorial reworking, especially in the MT, and less so in 4QSama, whereas the Septuagint mainly represents an older Hebrew Vorlage, often in agreement with 4QSama. The chain of changes concerning Hannah’s vow in the MT seems to spring from halakic motivation. The fact that the textual evidence is found to reveal processes at work during the editorial history of the text makes it evident that the borderline between so-called “lower” and “higher” criticism no longer exists. The paradigm shift after Qumran thus means a paradigm shift for the historical-critical methodology.
On the Use of Greek Translations in Dating the Shift from Targum Proto-Jonathan to Targum Yerushalmi in Ezekiel
Authors: Steiner Richard C. 
Published: August 2019

Abstract
It is generally believed that there was a shift in Eretz Israel from an Ur-targum to the Prophets (“Targum Proto-Jonathan”) to a later Palestinian offshoot (“Targum Yerushalmi”), whose precise character and origin are controversial. In each of these two targumim, the Aramaic term used to render Hebrew ‮קֶסֶת‬‎ (Ezek 9:2, 3, 11) is of Greek origin. Proto-Jonathan’s rendering, preserved as ‮פִינקַס‬‎ in Targum Jonathan, comes from a Greek term (πίναξ) related to Symmachus’s Greek rendering (πινακίδιον). Targum Yerushalmi’s rendering, preserved as ‮קלמרין‬‎ in MS Sassoon 368, is equivalent to the Greek rendering (καλαμάριον) attributed to “one of the Hebrews” by Origen in his commentary on Ezekiel. These correspondences, taken together with other evidence, suggest that Targum Proto-Jonathan to Ezekiel was still being used in Eretz Israel during Symmachus’s time (late second century CE), and that the shift from Proto-Jonathan to Targum Yerushalmi in Ezekiel had at least begun by the time that Origen completed his commentary on Ezekiel (fifth decade of the third century CE).
Thermodynamic Recovery of the Pressure and Temperature Fields over Complex Terrain Using Wind Fields Derived by Multiple-Doppler Radar Synthesis
Authors: Liou Yu-Chieng , Yang Po-Chien , Wang Wen-Yuan 
Published: August 2019

AbstractA new thermodynamic retrieval scheme is developed by which one can use the wind fields synthesized from multiple-Doppler radars to derive the three-dimensional thermodynamic fields over complex terrain. A cost function consisting of momentum equations and a simplified thermodynamic equation is formulated. By categorizing the analysis domain into flow and terrain regions, the variational technique is applied to minimize this cost function only within the flow region, leading to the solutions for the three-dimensional pressure and temperature perturbations immediately over terrain. Using idealized datasets generated by a numerical model, an experiment is first conducted to assess the accuracy of the proposed algorithm. The retrieval scheme is then applied to a real case that occurred during the 2008 Southwestern Monsoon Experiment (SoWMEX) conducted in Taiwan. The retrieved thermodynamic fields, verified by radiosonde data, reveal the structure of a prefrontal squall line as it approaches a mountain. The retrieved three-dimensional high-resolution pressure and temperature along with the wind fields not only allow us to better understand the thermodynamic and kinematic structure of a heavy rainfall system, but can also be assimilated into a numerical model to improve the forecast.
Assessing the quality of care for paediatric depression and anxiety in Australia: A population-based sample survey
Authors: Ellis Louise A , Wiles Louise K , Selig Ruth , Churruca Kate , Lingam Raghu , Long Janet C , Molloy Charlotte J , Arnolda Gaston , Ting Hsuen P , Hibbert Peter , Dowton S Bruce , Braithwaite Jeffrey 
Published: August 2019

Objective: We examine the prevalence of quality care (as measured by adherence to recommendations in clinical practice guidelines) for Australian paediatric patients (⩽15 years) with depression and/or anxiety, using data from the CareTrack Kids study; a population-based study of the quality of healthcare practice in inpatient and ambulatory healthcare settings. Methods: A multistage stratified sample identified records of 6689 children. Of these, 156 records were identified for depression and 356 for anxiety. These were assessed for adherence to 15 depression and 13 anxiety indicators, respectively, using a review of medical records. Results: Adherence to assessment and management guidelines was low for both conditions: assessment bundle (depression = 33%, 95% confidence interval = [20, 48]; anxiety = 54%, 95% confidence interval = [43, 64] and depression management bundle = 35%, 95% confidence interval = [15, 60]). Across both conditions, the highest adherence was recorded for indicators that addressed prescription of medications (e.g. venlafaxine, 100%; benzodiazepines, 100%; selective serotonin reuptake inhibitor, 94% and antidepressants, 91%), while compliance was the lowest for ensuring children with depression had an emergency safety plan (44%), informing parents of the risks and benefits of prescribed anxiety medication (51%) and assessment for other causes (59% for depression; 68% for anxiety). Conclusion: These findings suggest that strategies are needed to improve guideline adherence for mental health disorders in children and adolescents, particularly among general practitioners. Learning from these indicators could inform clinical prompts in electronic medical records, as well as links to additional information, to assist in decision-making and streamline work practices.
Country-Specific Determinants of Intra-Industry Trade in India
Authors: Bagchi Sagnik , Bhattacharyya Surajit 
Published: August 2019

A distinctive feature of India’s trade liberalization has been a significant rise in the magnitude of intra-industry trade (IIT). India’s total IIT is substantially large with high and upper-middle-income group countries and dominated by low vertical IIT. Particularly during the second phase of economic reforms, magnitude of India’s vertical IIT with high-income group of countries had increased; while there had been a marginal decline in horizontal IIT. This article identifies some of the determinants of India’s total IIT as well as vertical and horizontal IIT with her major trading partners from 1990 to 2014. The convergence in the level of economic development between India and her trading partner(s) positively influences total IIT and its two broad forms. Similarity in relative factor endowments and regional trade agreement through South Asian Free Trade Area (SAFTA) is found to promote horizontal IIT. Having a large market size, the distortionary impact of tariff has not been able to dampen the magnitude of India’s IIT. Relative depreciation of trading partner’s real exchange rate enhances India’s imports and inhibits the growth of total and vertical IIT. Geographical distance adversely affects all forms of IIT. JEL Codes: C23, F14
Empirical Analysis of the Determinants of Trade Balance in Post-liberalization Ghana
Authors: Akoto Linda , Sakyi Daniel 
Published: August 2019

This study investigates the determinants of trade balance in post-liberalization Ghana, covering the period 1984–2015. Specifically, we test the validity of the Marshall-Lerner condition and the J-curve effect, and further assess the effect of other macroeconomic variables including household consumption expenditure, government consumption expenditure, foreign income, money supply and domestic prices on trade balance. The bounds testing approach to cointegration and the error correction model within a symmetric and asymmetric autoregressive distributed lag (ARDL) framework is used for the estimation. Additionally, to analyse the dynamic interactions of the variables included in the estimated model, variance decomposition is applied. The results from both symmetric and asymmetric specifications show the absence of the Marshall-Lerner condition and the J-curve effect. Further, the study finds that household consumption expenditure, government consumption expenditure and domestic prices are negative and significant in the long and short run, whereas foreign income and money supply are positive and significant in the short run. Results from the variance decomposition show that innovations in household consumption expenditure highly contribute to the forecast error variance of the trade balance compared with other explanatory variables. A key finding of the study suggests that depreciation of the Ghana cedi is not an appropriate step to help in improving the country’s trade balance position. JEL Codes: C22, F10, F31, F32
Complications of veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock or cardiac arrest
Authors: Lee Soo Youn , Jeon Ki-Hyun , Lee Hyun Jong , Kim Ji-Bak , Jang Ho-Jun , Kim Je Sang , Kim Tae Hoon , Park Jin-Sik , Choi Rak Kyeong , Choi Young Jin 
Published: August 2019

Background: The frequency of using veno-arterial extracorporeal membrane oxygenation increased, especially in patients with refractory cardiogenic shock or cardiac arrest. However, data of complications of veno-arterial extracorporeal membrane oxygenation are lacking. This study sought to investigate the incidence of veno-arterial extracorporeal membrane oxygenation complications for acute myocardial infarction patients with refractory cardiogenic shock or cardiac arrest and its relationship with patient survival. Methods: This study included 151 consecutive patients who underwent veno-arterial extracorporeal membrane oxygenation between 2006 and 2018 at a single referral center. We divided the patients into those who survived for 30 days after veno-arterial extracorporeal membrane oxygenation ( n = 57, 38%; group 1) and those who died within 30 days after veno-arterial extracorporeal membrane oxygenation support ( n = 94, 62%; group 2). The major adverse clinical events associated with veno-arterial extracorporeal membrane oxygenation were defined as first occurrence of infection, major bleeding, and stroke. Results: Adverse clinical events associated with veno-arterial extracorporeal membrane oxygenation occurred in 34 (59.6%) and 56 (59.6%) patients in groups 1 and 2, respectively. Group 2 had more patients who underwent new renal replacement therapy (21.1% vs 37.2%, p = 0.037). After multivariable analysis, cardiac arrest was independently associated with 30-day mortality (odds ratio = 3.6; 95% confidence interval = 1.7–7.63; p = 0.001). After excluding patients who died within 48 h after undergoing veno-arterial extracorporeal membrane oxygenation, new renal replacement therapy (odds ratio = 4.47; 95% confidence interval = 1.58–12.61; p = 0.005) and major adverse clinical events (odds ratio = 2.66; 95% confidence interval = 1.01–7.03; p = 0.049) were independently associated with 30-day mortality. Conclusion: Although veno-arterial extracorporeal membrane oxygenation can improve the survival, it is associated with morbidity. Therefore, risk–benefit analysis for veno-arterial extracorporeal membrane oxygenation and prevention of complications are important to improve prognosis.
Should we worry about the eyes of celiac patients?
Authors: Doğan Güzide , Şen Semra , Çavdar Ercüment , Mayalı Hüseyin , Cengiz Özyurt Beyhan , Kurt Emin , Kasırga Erhun 
Published: August 2019

Purpose: In this article, we evaluate subfoveal choroidal thickness in celiac patients with respect to adherence to the gluten-free diet and nonadherence to the gluten-free diet, comparing with age and sex matched healthy controls using spectral-domain optical coherence tomography. Materials and Methods: A case-control study among 42 celiac patients and 42 healthy participants was conducted in the Department of Pediatric Gastroenterology. Celiac patients of our policlinics compliant with spectral-domain optical coherence tomography examination enrolled in the study. Celiac patients had been asked verbally about their adherence to gluten-free diet, were evaluated according to negative or positive EmA and anti-TG2 for defining adherence, and were divided into two groups (adherence to gluten-free diet and nonadherence to gluten-free diet). Results: Subfoveal choroidal thickness was thinner in EmA (+) or anti-TG2 (+) eyes than EmA(−) or anti-TG2 (−) eyes in celiac patients, but it was not statistically significant. The mean subfoveal choroidal thickness values in eyes with celiac disease, whose diagnosis time was longer than 60 months, were thinner than shorter group. Longer duration of gluten-free diet was associated with adherence difficulty and thinner choroidal thickness (r = −0.15, p = 0.34). Adherence to gluten-free diet was 88.2% for children below the age of 60 months and 57.1% for children older than 60 months. Conclusion: In conclusion, in addition to other extraintestinal manifestations of celiac disease, diagnosis time longer than 60 months in pediatric celiac patients, nonadherence to the gluten-free diet, and antibody positivity should be focused on during ophthalmologic examination and choroid measurement.
The effect of telehealth versus usual care for home-care patients with long-term conditions: A systematic review, meta-analysis and qualitative synthesis
Authors: McFarland Sophie , Coufopolous Anne , Lycett Deborah 
Published: August 2019

Introduction Approximately 26 million people in the United Kingdom are living with one long-term condition and 10 million are living with two or more; these figures are projected to continue increasing (NHS England 2018). People with long-term conditions are two to three times more likely to have poor psychological wellbeing and utilise 50% of GP appointments, 64% of outpatient appointments and over 70 of inpatient bed days. Research in this population could help with increasing constraints on healthcare budgets and resources. Technology-enabled healthcare in the community might help improve quality of life and reduce healthcare costs of managing chronic disease but the overall impact is unclear, we therefore conducted a systematic review. Methods Keywords and MeSH terms were used to search MEDLINE and CINAHL. We included qualitative and quantitative studies that reported on adult home-care patients diagnosed with at least one long-term condition, comparing telehealth to usual home care. Meta-analyses and sensitivity analyses were conducted using RevMan 5. Qualitative findings were thematically synthesised and reported narratively. Results In total, 2568 studies were identified and nine (2611 participants) were included. Telehealth was not statistically significantly different versus standard home care for quality of life, psychological wellbeing, physical function, anxiety, depression, disease specific outcomes or bed days of care at 3, 6, 9 and 12 months. Qualitative findings showed patients found telehealth was beneficial for providing peace of mind and legitimising access to healthcare. Conclusion Telehealth may offer reassurance to those living in the community with long-term conditions; however, a lack of high-quality studies and heterogeneity between interventions makes conclusions difficult.
Sexual Dysfunction in Women with Depressive Disorder: A Prospective, Hospital Based Study
Authors: Mujawar Swaleha , Chaudhury Suprakash , Saldanha Daniel 
Published: August 2019

Background: Depression causes emotional and physical disturbances which impacts biological functions such as sleep, appetite, libido, and disinterest in sexual function. Since discussing sexual problems is considered a taboo, there is limited data available concerning the prevalence of sexual dysfunction in women with depression and its response to treatment. Aim: To assess the prevalence of sexual dysfunction in females with depressive disorder and the effects of treatment. Material and Methods: A total of 53 females with recurrent depression and age and sex matched normal control group were included in the study with their informed consent. All the subjects were assessed with the Hamilton Rating Scale for Depression (HAM-D), Arizona sexual experience scale (ASEX), and female sexual functioning index (FSFI), which were re-administered after 6 weeks of treatment. Results: There was a significant difference in the HAM-D, ASEX, and FSFI scores between index and control groups at baseline. There was a significant correlation between the scores of HAM-D, ASEX, and FSFI before treatment. The correlation between the HAM-D and ASEX scores after treatment was not significant. A significant correlation was found between the HAM-D scores and the scores of arousal, lubrication, orgasm, satisfaction, pain, total domains of FSFI after treatment. No correlation was found between the HAM-D scores and desire domain score of FSFI after treatment. Conclusion: Women with depression have a high prevalence of sexual dysfunction. A highly significant improvement in depression and sexual functioning was observed at the end of 6 weeks of antidepressant therapy. Despite the improvement in sexual dysfunctions, the individual domains of sexual functions were not comparable to the normal subjects at the end of 6 weeks suggesting the need for longer treatment.
Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia
Authors: Zhu Yinghui , He Xin , Lin Yi-Chun , Dong Haojie , Zhang Lei , Chen Xianwei , Wang Zhihao , Shen Yudao , Li Min , Wang Hanying , Sun Jie , Nguyen Le Xuan , Zhang Han , Jiang Wenjuan , Yang Yanzhong , Chen Jianjun , Müschen Markus , Chen Chun-Wei , Konopleva Marina Y. , Sun Weili , Jin Jian , Carlesso Nadia , Marcucci Guido , Luo Yun , Li Ling 
Published: August 2019

Key Points
High PRMT1 expression maintains MLL-r ALL cell survival and growth by regulating FLT3 methylation at R972/973. PRMT1 inhibition enhances ablation of MLL-r ALL by tyrosine kinase inhibitor treatment.
Adrenocortical Carcinoma Xenograft in Zebrafish Embryos as a Model To Study the In Vivo Cytotoxicity of Abiraterone Acetate
Authors: Gianoncelli Alessandra , Guarienti Michela , Fragni Martina , Bertuzzi Michela , Rossini Elisa , Abate Andrea , Basnet Ram Manohar , Zizioli Daniela , Bono Federica , Terzolo Massimo , Memo Maurizio , Berruti Alfredo , Sigala Sandra 
Published: August 2019

Abstract
Abiraterone acetate (AbiAc) inhibits tumor growth when administered to immunodeficient mice engrafted with the in vitro cell model of human adrenocortical carcinoma (ACC). Here, we developed and validated a zebrafish model engrafted with cortisol-secreting ACC cells to study the effects of AbiAc on tumor growth. The experimental conditions for AbiAc absorption in AB zebrafish embryos including embryo number, AbiAc concentration, and absorption time curve by liquid chromatography–tandem mass spectrometry were set up. The AbiAc effect on steroid production in AB zebrafish embryos was measured as well. ACC cells (the NCI-H295R cell line, the primary cell ACC29, and the negative control cell SW13) were treated with drug-induced liver injury fluorescent dye, and ∼240 cells per 4 nL was injected in the subperidermal space of the yolk sac of AB zebrafish embryos (n = 80 ± 10). The cell area was measured with Noldus DanioScopeTM software. AbiAc absorption in AB zebrafish embryos was stage dependent. Abiraterone (Abi) concentration decreased, whereas its main metabolite, Δ4A, increased. Accordingly, we demonstrated that zebrafish expressed mRNA encoding the enzyme 3β-hydroxysteroid dehydrogenase, which converts Abi in Δ4A. Furthermore, ABiAc reduced cortisol production and increased progesterone in zebrafish embryos. Three days after cell injection, the cortisol-secreting ACC cell area in solvent-treated embryos was significantly higher than that in 1 µM AbiAC‒treated embryos, whereas no AbiAc effect was observed in SW13 cells, which lack the Abi target enzyme CYP17A1.Zebrafish embryos xenografted with ACC tumor cells could be a useful, fast, and reproducible experimental model to preclinically test the activity of new drugs in human ACC.