bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural and Geochronological Constraints on Devonian Suprasubduction Tectonic Switching and Permian Collisional Dynamics in the Chinese Altai, Central Asia
Authors: Jiang Y. D. , Schulmann K. , Sun M. , Weinberg R. F. , Štípská P. , Li P. F. , Zhang J. , Chopin F. , Wang S. , Xia X. P. , Xiao W. J. 
Published: December 2018

AbstractKinematic significance and time scales of geodynamic processes forming the Altai Orogenic Belt are addressed through structural and petrological analysis combined with zircon and monazite geochronology. The study area is composed of orogenic lower crust represented by a Devonian migmatite‐magmatite complex and orogenic middle and upper crust formed by an amphibolite‐facies Ordovician sedimentary sequence and a weakly to unmetamorphosed Devonian volcano‐sedimentary cover, respectively. The orogenic lower and middle crust were first affected by moderate thickening, which formed subhorizontal Barrovian metamorphic schistosity. This fabric was reworked by deep crustal melting and intrusion of granite sheets during horizontal extension at 400–380 Ma. Soon after, this horizontal fabric was affected by NW‐SE shortening generating crustal‐scale upright folding associated with subvertical flow of still partially molten orogenic lower crust. During this event, the orogenic lower and middle crust were tightly juxtaposed with upper crustal sedimentary rocks. The last event was related with a NE‐SW oriented convergence resulting in large‐scale folding and megafold interference pattern in the Permian at 280–273 Ma. Combined with existing regional data, our results allow proposing a Devonian tectonic switching from compression to extension and back to compression, as a response to variations of subduction dynamics between slab advance and retreat in a Pacific‐type suprasubduction system. The Permian folding was associated with the progressive northward exhumation of thermally softened crust. This tectonic evolution is in response to the indentation of the rigid Junggar arc domain into the weak Altai wedge.
Serial Reduction of an Extremely Large Gastroschisis using Vacuum-Assisted Closure
Authors: Butler Marilyn , Fuchs Julie , Bruzoni Matias 
Published: December 2018

AbstractWe herein describe a case of serial reduction of an extremely large and complex gastroschisis using vacuum-assisted closure (VAC) therapy in a boy born at 355/7 weeks' gestation. A spring-loaded silicone silo was placed at birth. By day of life (DOL) 22, minimal visceral contents had been reduced, and the silo was difficult to maintain due to the size of the fascial defect and loss of abdominal domain. A bespoke VAC dressing was constructed, and biweekly dressing changes allowed gradual reduction of the gastroschisis until the viscera were consolidated. By DOL 50, the viscera were completely reduced, and VAC therapy was discontinued. Feeds were commenced on DOL 57 and increased to goal by DOL 86. The baby was discharged home on DOL 115. We conclude that VAC dressings can be used to aid gradual reduction of an extremely large gastroschisis, particularly in medical fragile infants.
MRI-visible liposome–polyethylenimine complexes for DNA delivery: preparation and evaluation
Authors: Song Xiaowei , Yan Guanghai , Quan Songshi , Jin Enhao , Quan Jishan , Jin Guangyu 
Published: December 2018

ABSTRACTTo noninvasively monitor the effect of gene therapy and achieve an optimal therapeutic effect, liposomes encapsulated polyethylenimine (PEI)-coated superparamagnetic iron oxide nanoparticles (SPION) with dual functions of MRI diagnosis and gene therapy were prepared. SPION was synthesized via co-precipitation, and then modified with PEI via thiourea reaction. The liposomes encapsulating PEI-SPION (LP-PEI-SPION) were prepared by ethanol injection. Fourier transform infrared spectra confirmed that PEI was successfully modified onto SPION, and thermogravimetric analysis indicated that the PEI content was about 17.1%. The LP-PEI-SPION/DNA had a small particle size of 253.07 ± 0.90 nm. LP-PEI-SPION/DNA had low cytotoxicity with more than 80% of the cell survival rates and high transfection efficiency compared with Lipofectamine® 2000/DNA. Additionally, it also showed good MRI effect on three cell lines. The liposomes encapsulating PEI-SPION (lipopolyplexes) have been successfully prepared as MRI contrast agents and gene delivery vectors, which may have great theoretical research significance and clinical potentials.Abbreviations: PEI, polyethylenimine; SPION, superparamagnetic iron oxide nanoparticles; LP-PEI-SPION, liposomes encapsulating PEI-SPION; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; ICP-MS, inductively coupled plasma mass spectrometry; XRD, X-ray diﬀraction; TEM, transmission electron microscope; TGA, thermogravimetric analysis; DOTAP, 1,2-dioleoyl-3-trimethylammonium-propane; DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; Chol, cholesterol.
Illness Perceptions in Chronic Lymphocytic Leukemia: Testing Leventhal’s Self-regulatory Model
Authors: Westbrook Travis D , Morrison Eleshia J , Maddocks Kami J , Awan Farrukh T , Jones Jeffrey A , Woyach Jennifer A , Johnson Amy J , Byrd John C , Andersen Barbara L 
Published: December 2018

Abstract

Background
Leventhal’s Self-regulatory Model proposes that somatic characteristics of a health threat (e.g., symptom severity), and prior experience with the threat (e.g., unsuccessful treatment), are determinants of illness perceptions. Chronic lymphocytic leukemia (CLL) is appropriate for test of these postulates, having three phases differing in symptom severity and prior treatment experiences: indolent disease requiring no treatment (active surveillance; AS), symptomatic disease requiring a first treatment (FT), and highly symptomatic disease in those who have relapsed and/or failed to respond to prior treatments (relapsed/refractory; RR).

Purpose
To test symptom severity and prior treatment experiences as determinants of illness perceptions, illness perceptions were characterized and contrasted between CLL groups.

Methods
Three hundred and thirty CLL patients (AS, n = 100; FT, n = 78; RR, n = 152) provided illness perception data on one occasion during a surveillance visit (AS) or prior to beginning treatment (FT, RR).

Results
Analysis of variance with planned comparisons revealed that consequences, identity, and concern were least favorable among RR patients, followed by FT, then AS (ps < .01). AS patients endorsed the lowest levels of coherence (ps < .01), and the most chronic illness timeline (ps < .01). FT patients endorsed the highest levels of personal and treatment control (ps < .01).

Conclusions
Data provide preliminary empirical support for Self-regulatory Model postulates that symptom severity and prior disease experiences influence illness perceptions. Unique knowledge needs for AS patients and elevated psychological/physical symptoms for later-stage CLL patients may warrant clinical attention.
Mycorrhiza-Induced Resistance in Potato Involves Priming of Defense Responses Against Cabbage Looper (Noctuidae: Lepidoptera)
Authors: Schoenherr Andrew P , Rizzo Eric , Jackson Natasha , Manosalva Patricia , Gomez S Karen 
Published: December 2018

Abstract
Most plants form mutualistic associations with arbuscular mycorrhizal (AM) fungi that are ubiquitous in soils. Through this symbiosis, plants can withstand abiotic and biotic stresses. The underlying molecular mechanisms involved in mediating mycorrhiza-induced resistance against insects needs further research, and this is particularly true for potato (Solanum tuberosum L. (Solanales: Solanaceae)), which is the fourth most important crop worldwide. In this study, the tripartite interaction between potato, the AM fungus Rhizophagus irregularis (Glomerales: Glomeraceae), and cabbage looper (Trichoplusia ni Hübner) (Lepidoptera: Noctuidae) was examined to determine whether potato exhibits mycorrhiza-induced resistance against this insect. Plant growth, insect fitness, AM fungal colonization of roots, and transcript levels of defense-related genes were measured in shoots and roots after 5 and 8 d of herbivory on mycorrhizal and nonmycorrhizal plants. AM fungal colonization of roots did not have an effect on potato growth, but root colonization levels increased by herbivory. Larval weight gain was reduced after 8 d of feeding on mycorrhizal plants compared with nonmycorrhizal plants. Systemic upregulation of Allene Oxide Synthase 1 (AOS1), 12-Oxo-Phytodienoate Reductase 3 (OPR3) (jasmonic acid pathway), Protease Inhibitor Type I (PI-I) (anti-herbivore defense), and Phenylalanine Ammonia Lyase (PAL) transcripts (phenylpropanoid pathway) was found during the tripartite interaction. Together, these findings suggest that potato may exhibit mycorrhiza-induced resistance to cabbage looper by priming anti-herbivore defenses aboveground. This study illustrates how mycorrhizal potato responds to herbivory by a generalist-chewing insect and serves as the basis for future studies involving tripartite interactions with other pests.
Anticholinergic Drug Induced Cognitive and Physical Impairment: Results from the InCHIANTI Study
Authors: Sargent Lana , Nalls Mike , Amella Elaine J , Mueller Martina , Lageman Sarah K , Bandinelli Stefania , Colpo Marco , Slattum Patricia W , Singleton Andrew , Ferrucci Luigi 
Published: December 2018

Abstract

Background
The aims of this study were to evaluate the relationship between anticholinergic drug burden (ACB) cognitive impairment, physical frailty, and cognitive frailty, and to determine if ACB is predictive of these phenotypes when modeled with biological and genomic biomarkers.

Methods
In a retrospective cohort study, a total of 1,453 adults aged 20–102 years were used to examine ACB as a predictor for cognitive impairment, physical frailty, and cognitive frailty. Anticholinergic burden is examined as a predictor for all phenotypes in a cross-sectional analysis using logistic, ordinal regression models, and Extreme Gradient Boosting for population predictive modeling.

Results
A significant association was found between ACB and cognitive decline (p = .02), frailty (p &lt; .001), and cognitive frailty (p &lt; .001). The odds of cognitive impairment increased by 1.21 (95% confidence interval [CI] = 1.06–1.37, p &lt; .001), odds of being frail increased by 1.33 (95% CI = 1.18–1.50, p &lt; .001), and odds of having cognitive frailty increased by 1.36 (95% CI = 1.21–1.54, p &lt; .001). Population modeling results indicated ACB score as one of the stronger predictors for cognitive impairment, physical frailty, and cognitive frailty with area under the curves ranging from 0.81 to 0.88.

Conclusions
Anticholinergic medications are a potentially modifiable risk factor for the prevention of cognitive and physical decline. Identification of reversible causes for cognitive and physical impairment is critical for the aging population. These findings encourage new research that may lead to effective interventions for deprescribing programs for the prevention of cognitive and physical decline in older adults.
Probable Donor-Derived Human Adenovirus Type 34 Infection in 2 Kidney Transplant Recipients From the Same Donor
Authors: Pettengill Matthew A , Babu Tara M , Prasad Paritosh , Chuang Sally , Drage Michael G , Menegus Marilyn , Lamson Daryl M , Lu Xiaoyan , Erdman Dean , Pecora Nicole 
Published: December 2018

AbstractHuman adenovirus type 34 (HAdV-34) infection is a recognized cause of transplant-associated hemorrhagic cystitis and, in rare cases, tubulointerstitial nephritis. The source of such infections is often difficult to assess, that is, whether acquired as a primary infection, exposure to a pathogen in the transplanted organ, or reactivation of an endogenous latent infection. We present here 2 cases of likely transplant-acquired HAdV-34 infection from the same organ donor, manifesting as tubulointerstitial nephritis in 1.
Reactivation of Hepatitis B Virus With Immune-Escape Mutations After Ocrelizumab Treatment for Multiple Sclerosis
Authors: Ciardi Maria R , Iannetta Marco , Zingaropoli Maria A , Salpini Romina , Aragri Marianna , Annecca Rosanna , Pontecorvo Simona , Altieri Marta , Russo Gianluca , Svicher Valentina , Mastroianni Claudio M , Vullo Vincenzo 
Published: December 2018

Abstract
Ocrelizumab is an anti-CD20 monoclonal antibody for the treatment of multiple sclerosis (MS) that is closely related to rituximab. We describe a case of hepatitis B virus (HBV) reactivation in an MS patient with resolved HBV infection receiving ocrelizumab. HBV reactivation was monitored with HBV-DNA and HBV surface antigen periodic assessment. Anti-HBV treatment with entecavir was started after HBV-DNA detection. Ocrelizumab can reactivate viral replication in patients with resolved HBV infection. HBV reactivation monitoring seems an effective and safe option for the management of these patients. More studies are needed to assess the optimal management of HBV reactivation in MS patients on ocrelizumab treatment.
Use of Closed-Incision Negative-Pressure Therapy in Aesthetic Surgery
Authors: Singh Devinder , Lobach Virginia , Holton Tripp 
Published: December 2018

Background:
Recently published studies have demonstrated clinical effectiveness of closed-incision negative-pressure therapy (ciNPT) in many fields of surgery including vascular, cardiac, colorectal, orthopedic, and reconstructive surgery. A review of current literature was conducted to determine whether the application of negative-pressure therapy to closed incisions post aesthetic procedures was beneficial.

Methods:
The PubMed/MEDLINE databases were searched for preclinical and clinical studies published through June 2018. Higher quality publications that met the following criteria were included: adult patients undergoing aesthetic or body contouring procedures, comparison of ciNPT with conventional dressings, and documentation of wound complications and/or incision quality.

Results:
One animal and multiple small, retrospective comparison articles are discussed. Scientific mechanism of action and economic analysis are also discussed. There are no level 1 randomized prospective controlled trials that directly evaluate the effects of ciNPT dressings in cosmetic patients.

Conclusion:
For patients undergoing certain cosmetic procedures, preliminary data support the idea that ciNPT dressings provide aesthetic benefit, but more research is clearly needed.
Use of Closed-Incision Negative-Pressure Therapy in Obstetrics
Authors: Feinstein Glen I. 
Published: December 2018

Background:
Cesarean delivery is one of the most commonly performed surgeries in the United States. Compared with other surgical procedures, surgical site infection tends to be a relatively uncommon outcome after cesarean delivery in the general population with an incidence rate between 1.46 and 3.82% in the United States in 2006–2008. Despite this lower incidence, surgical site infections following cesarean delivery result in a 6-day increase in mean length of stay at an additional cost of $13,968. Specifically, closed-incision negative-pressure therapy (ciNPT) has been developed for use over clean, closed surgical incisions. A brief literature review on ciNPT use over cesarean delivery incisions is described.

Methods:
A literature search was performed using PubMed and Google Scholar. The search included publications between January 1, 2005, and April 30, 2018, and focused on studies reporting the use of a specific ciNPT system (PREVENA Incision Management System; KCI, an Acelity Company, San Antonio, TX) over cesarean incisions.

Results:
Five published articles were identified in the literature search that compared ciNPT use to traditional dressings. Positive clinical outcomes were reported in 2 studies, similar outcomes between ciNPT and traditional dressings were reported in 2 studies, and negative outcomes were reported in 1 study.

Conclusions:
A lack of published literature reporting clinical outcomes following ciNPT use over cesarean delivery incisions exists, and the currently reported evidence is heterogeneous. As such, increased published evidence from large, randomized studies and a reexamination of ciNPT use over cesarean delivery incisions are needed.
Use of Closed-Incision Negative-Pressure Therapy: Cardiothoracic and Vascular Surgery
Authors: Wu Robin T. , Sumpio Brandon J. , Miller Samuel , Sumpio Bauer E. 
Published: December 2018

Summary:
Vascular groin wound and median sternotomy infections are challenging complications that may lead to serious sequela. Traditional gauze dressings have poor bacteria barrier properties, and so there has been a recent enthusiasm for the use of closed-incision negative-pressure therapy as an effective closed environment, which controls exudate and helps hold the incision edges together. Studies suggest that it may reduce surgical site infection in cardiothoracic and vascular surgery.
Inhibition of EZH2 ameliorates lupus-like disease inMRL/lprmice
Authors: Rohraff Dallas M. , He Ye , Farkash Evan A. , Schonfeld Mark , Tsou Pei-Suen , Sawalha Amr H. 
Published: December 2018

AbstractObjectivesWe previously revealed a role for EZH2 in inducing pro-inflammatory epigenetic changes in lupus CD4+ T cells. In this study, we sought to determine if inhibiting EZH2 ameliorates lupus-like disease in MRL/lprmice.MethodsEZH2 expression levels in multiple cell types in lupus patients were evaluated using flow cytometry and mRNA expression data. Inhibition of EZH2 in MRL/lprmice was achieved by DZNep intraperitoneal administration using a preventative and a therapeutic treatment model. Effects of DZNep on animal survival, anti-dsDNA antibody production, proteinuria, renal histopathology, cytokine production, and T and B cell numbers and percentages were assessed.ResultsEZH2 expression levels were increased in whole blood, neutrophils, monocytes, B cells, and CD4+ T cells in lupus patients. In MRL/lprmice, inhibiting EZH2 with DZNep treatment before or after disease onset improved survival and significantly reduced anti-dsDNA antibody production. DZNep-treated mice displayed a significant reduction in renal involvement, splenomegaly, and lymphadenopathy.Lymphoproliferation and numbers of double-negative T cells were significantly reduced in DZNep treated mice. Concentrations of circulating cytokines and chemokines, including TNF, IFN-γ, CCL2, RANTES/CCL5, IL-10, KC/CXCL1, IL-12, IL-12p40 and MIP-1β/CCL4 were decreased in DZNep treated mice.ConclusionsZH2 is upregulated in multiple cell types in lupus patients. Therapeutic inhibition of EZH2 abrogates lupus-like disease in MRL/lprmice, suggesting that EZH2 inhibitors may be repurposed as a novel therapeutic option in lupus patients.
Gpr158 deficiency impacts hippocampal CA1 neuronal excitability, dendritic architecture, and affects spatial learning
Authors: Çetereisi Demirhan , Kramvis Ioannis , Gebuis Titia , van der Loo Rolinka J. , Gouwenberg Yvonne , Mansvelder Huibert D. , Li Ka Wan , Smit August B , Spijker Sabine 
Published: December 2018

AbstractG-protein-coupled receptor 158 (Gpr158) is highly expressed in striatum, hippocampus and prefrontal cortex. It gained attention as it was implicated in physiological responses to stress and depression. Recently, Gpr158 has been shown to act as a pathway-specific synaptic organizer in the hippocampus, required for proper mossy fiber-CA3 neurocircuitry establishment, structure, and function. Although rodent Gpr158 expression is highest in CA3, considerable expression occurs in CA1 especially after the first postnatal month. Here, we combined hippocampal-dependent behavioral paradigms with subsequent electrophysiological and morphological analyses from the same group of mice to assess the effects of Gpr158 deficiency on CA1 physiology and function. We demonstrate deficits in spatial memory acquisition and retrieval in the Morris water maze paradigm, along with deficits in the acquisition of extinction memory in the passive avoidance test in Gpr158 KO mice. Electrophysiological recordings from CA1 pyramidal neurons revealed normal basal excitatory and inhibitory synaptic transmission, however, Schaffer collateral stimulation yielded dramatically reduced post-synaptic currents. Interestingly, intrinsic excitability of CA1 pyramidals was found increased, potentially acting as a compensatory mechanism to the reductions in Schaffer collateral-mediated drive. Both ex vivo and in vitro, neurons deficient for Gpr158 exhibited robust reductions in dendritic architecture and complexity, i.e., reduced length, surface, bifurcations, and branching. This effect was localized in the apical but not basal compartment of adult CA1 pyramidals, indicative of pathway-specific alterations. A significant positive correlation between spatial memory acquisition and extent of complexity of CA1 pyramidals was found. Taken together, we provide first evidence of significant disruptions in hippocampal CA1 neuronal dendritic architecture and physiology, driven by Gpr158 deficiency. Importantly, the hippocampal neuronal morphology deficits appear to support the impairments in spatial memory acquisition observed in Gpr158 KO mice.
Serial synapse formation through filopodial competition for synaptic seeding factors
Authors: Özel M. Neset , Kulkarni Abhishek , Hasan Amr , Brummer Josephine , Moldenhauer Marian , Daumann Ilsa-Maria , Wolfenberg Heike , Dercksen Vincent J. , Kiral F. Ridvan , Weiser Martin , Prohaska Steffen , von Kleist Max , Hiesinger P. Robin 
Published: December 2018

SummaryFollowing axon pathfinding, growth cones transition from stochastic filopodial exploration to the formation of a limited number of synapses. How the interplay of filopodia and synapse assembly ensures robust connectivity in the brain has remained a challenging problem. Here, we developed a new 4D analysis method for filopodial dynamics and a data-driven computational model of synapse formation for R7 photoreceptor axons in developing Drosophila brains. Our live data support a ‘serial synapse formation’ model, where at any time point only a single ‘synaptogenic’ filopodium suppresses the synaptic competence of other filopodia through competition for synaptic seeding factors. Loss of the synaptic seeding factors Syd-1 and Liprin-α leads to a loss of this suppression, filopodial destabilization and reduced synapse formation, which is sufficient to cause the destabilization of entire axon terminals. Our model provides a filopodial ‘winner-takes-all’ mechanism that ensures the formation of an appropriate number of synapses.