bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large-scale wearable data reveal digital phenotypes for daily-life stress detection
Authors: Smets Elena , Rios Velazquez Emmanuel , Schiavone Giuseppina , Chakroun Imen , D’Hondt Ellie , De Raedt Walter , Cornelis Jan , Janssens Olivier , Van Hoecke Sofie , Claes Stephan , Van Diest Ilse , Van Hoof Chris 
Published: December 2018

AbstractPhysiological signals have shown to be reliable indicators of stress in laboratory studies, yet large-scale ambulatory validation is lacking. We present a large-scale cross-sectional study for ambulatory stress detection, consisting of 1002 subjects, containing subjects’ demographics, baseline psychological information, and five consecutive days of free-living physiological and contextual measurements, collected through wearable devices and smartphones. This dataset represents a healthy population, showing associations between wearable physiological signals and self-reported daily-life stress. Using a data-driven approach, we identified digital phenotypes characterized by self-reported poor health indicators and high depression, anxiety and stress scores that are associated with blunted physiological responses to stress. These results emphasize the need for large-scale collections of multi-sensor data, to build personalized stress models for precision medicine.
Air-stable phosphorus-doped molybdenum nitride for enhanced electrocatalytic hydrogen evolution
Authors: Yan Junqing , Kong Lingqiao , Ji Yujin , Li Youyong , White Jai , Liu Shengzhong , Han Xiaopeng , Lee Shuit-Tong , Ma Tianyi 
Published: December 2018

AbstractMolybdenum-based electrocatalysts for hydrogen evolution have been investigated extensively in recent years. However, unlike other non-oxides, molybdenum nitride generally shows a weak preference for hydrogen evolution and low performance owing to surface oxidation and the strong Mo–H bond. Here, we prepare an air-stable molybdenum nitride through a multi-step solid-state reaction. We find that a uniformly dispersed mixture of the precursors is optimal for preparation of the electrocatalyst. To further enhance hydrogen evolution performance towards practical device applications, phosphorus doping is carried out, using a few layered black phosphorus source. The phosphorus-doped molybdenum nitride (P–Mo–N) sample catalyzes hydrogen evolution with potentials of 105, 145, and 157 mV at the current densities of 10, 50, and 100 mA/cm2, respectively, in 0.5 M H2SO4 solution with a small Tafel slope of 43 mV/dec. Thus it outperforms many of the state-of-art molybdenum-based hydrogen evolution catalysts reported to date.
Glycerol-3-phosphate acyltransferases 3 and 4 direct glycerolipid synthesis and affect functionality in activated macrophages
Authors: Quiroga Ivana Y. , Pellon-Maison Magali , Suchanek Amanda L. , Coleman Rosalind A. , Gonzalez-Baro Maria R. 
Published: December 2018

Abstract
Macrophage classical M1 activation via TLR4 triggers a variety of responses to achieve the elimination of foreign pathogens. During this process, there is also an increase in lipid droplets which contain large quantities of triacylglycerol (TAG) and phospholipid (PL). The functional consequences of this increment in lipid mass are poorly understood. Here, we studied the contribution of glycerolipid synthesis to lipid accumulation, focusing specifically on the first and rate-limiting enzyme of the pathway: glycerol-3-phosphate acyltransferase (GPAT). Using bone marrow-derived macrophages (BMDMs) treated with Kdo2-lipid A, we showed that glycerolipid synthesis is induced during macrophage activation. GPAT4 protein level and GPAT3/GPAT4 enzymatic activity increase during this process, and these two isoforms were required for the accumulation of cell TAG and PL. The phagocytic capacity of Gpat3−/− and Gpat4−/− BMDM was impaired. Additionally, inhibiting fatty acid β-oxidation reduced phagocytosis only partially, suggesting that lipid accumulation is not necessary for the energy requirements for phagocytosis. Finally, Gpat4−/− BMDM expressed and released more pro-inflammatory cytokines and chemokines after macrophage activation, suggesting a role for GPAT4 in suppressing inflammatory responses. Together, these results provide evidence that glycerolipid synthesis directed by GPAT4 is important for the attenuation of the inflammatory response in activated macrophages.
Hemin induces autophagy in a leukemic erythroblast cell line through the LRP1 receptor
Authors: Grosso Ruben Adrian , Caldarone Paula Virginia Subirada , Sánchez María Cecilia , Chiabrando Gustavo Alberto , Colombo María Isabel , Fader Claudio Marcelo 
Published: December 2018

Abstract
Hemin is an erythropoietic inductor capable of inducing autophagy in erythroid-like cell lines. Low-density lipoprotein receptor-related protein 1 (LRP1) is a transmembrane receptor involved in a wide range of cellular processes, such as proliferation, differentiation, and metabolism. Our aim was to evaluate whether LRP1 is responsible for hemin activity in K562 cells, with the results demonstrating a three-fold increase in LRP1 gene expression levels (P-values &lt;0.001) when assessed by quantitative real-time RT-PCR (qRT-PCR). Moreover, a 70% higher protein amount was observed compared with control condition (P-values &lt;0.01) by Western blot (WB). Time kinetic assays demonstrated a peak in light chain 3 (LC3) II (LC3II) levels after 8 h of hemin stimulation and the localization of LRP1 in the autophagosome structures. Silencing LRP1 by siRNA decreased drastically the hemin-induced autophagy activity by almost 80% compared with control cells (P-values &lt;0.01). Confocal localization and biochemical analysis indicated a significant redistribution of LRP1 from early endosomes and recycling compartments to late endosomes and autophagolysosomes, where the receptor is degraded. We conclude that LRP1 is responsible for hemin-induced autophagy activity in the erythroblastic cell line and that hemin–LRP1 complex activation promotes a self-regulation of the receptor. Our results suggest that hemin, via the LRP1 receptor, favors erythroid maturation by inducing an autophagic response, making it a possible therapeutic candidate to help in the treatment of hematological disorders.
Identifiers of Language Impairment for Spanish–English Dual Language Learners
Authors: Lazewnik Rochel , Creaghead Nancy A. , Smith Allison Breit , Prendeville Jo-Anne , Raisor-Becker Lesley , Silbert Noah 
Published: December 2018

Purpose
The purpose of this study was to determine if a standardized assessment developed for Spanish–English dual language learners (SEDLLs) differentiates SEDLLs with language impairment (LI) from children with typical language better than the translated/adapted Spanish and/or English version of a standardized assessment and to determine if adding informal measure/s to the standardized assessment increases the classification accuracy.

Method
Standardized and informal language assessment measures were administered to 30 Mexican American 4- to 5-year-old SEDLLs to determine the predictive value of each measure and the group of measures that best identified children with LI and typical language. Discriminant analyses were performed on the data set.

Results

The Morphosyntax and Semantics subtests of the Bilingual English–Spanish Assessment (
Peña, Gutierrez-Clellen, Iglesias, Golstein, & Bedore, 2014
) resulted in the largest effect size of the individual assessments with a sensitivity of 93.3% and a specificity of 86.7%. Combining these subtests with mean length of utterance in words from the child's better language sample (English or Spanish) was most accurate in identifying LI and can be used with above 90% confidence.

Conclusion
The Bilingual English–Spanish Assessment Morphosyntax and Semantics subtests were shown to comprise an effective measure for identifying LI; however, including a language sample is suggested to identify LI with greater accuracy.
The progenitors of type-Ia supernovae in semidetached binaries with red giant donors
Authors: Liu D. , Wang B. , Ge H. , Chen X. , Han Z. 
Published: December 2018

Context. The companions of the exploding carbon-oxygen white dwarfs (CO WDs) that produce type-Ia supernovae (SNe Ia) have still not been conclusively identified. A red-giant (RG) star can fill this role as the mass donor of the exploding WD − this channel for producing SNe Ia has been named the symbiotic channel. However, previous studies on this channel have given a relatively low rate of SNe Ia.
Aims. We aim to systematically investigate the parameter space, Galactic rates, and delay time distributions of SNe Ia arising from the symbiotic channel under a revised mass-transfer prescription.
Methods. We adopted an integrated mass-transfer prescription to calculate the mass-transfer process from a RG star onto the WD. In this prescription, the mass-transfer rate varies with the local material states. First, we obtain the parameter space that leads to SNe Ia by evolving a large number of semidetached WD+RG systems with the Eggleton stellar-evolution code. Second, we investigate the Galactic rates and delay-time distributions of SNe Ia using a binary population synthesis method.
Results. The parameter space of WD+RG systems that can produce SNe Ia is enlarged significantly judging by our calculations. This channel could produce SNe Ia with intermediate and old ages, contributing up to 5% of all SNe Ia in the Galaxy. Our model increases the SN Ia rate from this channel by a factor of five. We suggest that the symbiotic systems RS Oph and T CrB are strong candidates for the progenitors of SNe Ia.
Evolution of star–planet systems under magnetic braking and tidal interaction
Authors: Benbakoura M. , Réville V. , Brun A. S. , Le Poncin-Lafitte C. , Mathis S. 
Published: December 2018

Context.With the discovery over the last two decades of a large diversity of exoplanetary systems, it is now of prime importance to characterize star–planet interactions and how such systems evolve.Aims.We address this question by studying systems formed by a solar-like star and a close-in planet. We focus on the stellar wind spinning down the star along its main-sequence phase and tidal interaction causing orbital evolution of the systems. Despite recent significant advances in these fields, all current models use parametric descriptions to study at least one of these effects. Our objective is to introduce ab initio prescriptions of the tidal and braking torques simultaneously, so as to improve our understanding of the underlying physics.Methods.We develop a one-dimensional (1D) numerical model of coplanar circular star–planet systems taking into account stellar structural changes, wind braking, and tidal interaction and implement it in a code called ESPEM. We follow the secular evolution of the stellar rotation and of the semi-major axis of the orbit, assuming a bilayer internal structure for the former. After comparing our predictions to recent observations and models, we perform tests to emphasize the contribution of ab initio prescriptions. Finally, we isolate four significant characteristics of star–planet systems: stellar mass, initial stellar rotation period, planetary mass and initial semi-major axis; and browse the parameter space to investigate the influence of each of them on the fate of the system.Results.Our secular model of stellar wind braking accurately reproduces the recent observations of stellar rotation in open clusters. Our results show that a planet can affect the rotation of its host star and that the resulting spin-up or spin-down depends on the orbital semi-major axis and on the joint influence of magnetic and tidal effects. The ab initio prescription for tidal dissipation that we used predicts fast outward migration of massive planets orbiting fast-rotating young stars. Finally, we provide the reader with a criterion based on the characteristics of the system that allows us to assess whether or not the planet will undergo orbital decay due to tidal interaction.
Unterwegs in den Familien
Authors: Absalon Susanne , Kocks Andreas 
Published: December 2018

ZusammenfassungNina Braun ist gelernte Gesundheits- und Kinderkrankenpflegerin seit 1995 mit
einer Weiterbildung zur Familien-Gesundheits- und Kinderkrankenpflege, Sonja
Hotz ist Hebamme seit 1988 mit der Fachqualifikation Familienhebamme. Beide sind
in Bonn im lokalen Netzwerk der Frühen Hilfen in den Familien unterwegs. Im
folgenden Interview berichten sie von ihrer Arbeit.
Das UroLift® System in der Behandlung des benignen Prostata-Syndroms (BPS)
Authors: Westhofen Thilo , Magistro Giuseppe , Stief Christian , Gratzke Christian 
Published: December 2018

ZusammenfassungMinimalinvasive Therapieverfahren des benignen Prostatasyndroms (BPS) gewinnen bei ähnlich effektiver Therapiewirkung wie bewährte OP-Verfahren jedoch günstigerem Sicherheitsprofil zunehmend an Bedeutung. Unter den minimalinvasiven Verfahren hat sich in der klinischen Evaluation das UroLift-Verfahren in der langfristigen Beurteilung hinsichtlich postoperativer Ergebnisse sowie Komplikationsraten bewährt. Deutlich überlegen zeigt sich UroLift für den kompletten Erhalt der sexuellen Funktion, inklusive einer antegraden Ejakulation.
Neuropathic Pain
Authors: Otis James , Macone Amanda 
Published: December 2018

AbstractNeuropathic pain management is challenging, and typically requires a multifaceted approach. There are several treatment options, both pharmacologic and nonpharmacologic. Of the available pharmacologic agents, those with the strongest supporting evidence include tricyclic antidepressants, serotonin–norepinephrine reuptake inhibitors, and certain antiseizure agents. There is emerging evidence for the use of cannabinoids, but conclusive studies are not available. Nonpharmacologic therapies that have been utilized in the management of neuropathic pain include acupuncture, massage therapy, and reflexology. Despite their use as adjunctive therapies in clinical practice, the current evidence supporting their use is not strong. For the management of neuropathic pain, combination therapies are generally employed. Additional studies for emerging therapies are still needed.
Headache in Pregnancy, the Puerperium, and menopause
Authors: Sader Elie , Rayhill Melissa 
Published: December 2018

AbstractHeadache is a neurologic disorder that displays gender dichotomy. It is well established that there is a strong link between migraine headache and sex hormones, specifically estrogen, which influences the severity of migraines during the menstrual cycle, pregnancy, and menopause. Furthermore, the epidemiology of headaches during pregnancy and the postpartum period is very distinct from that in males or nonpregnant females, in part due to the hemodynamic and hematologic changes that occur during pregnancy. These changes put women at higher risk for cerebral venous thrombosis, hemorrhagic stroke, and hypertensive disorders of pregnancy like preeclampsia, eclampsia, posterior reversible encephalopathy syndrome, and reversible cerebral vasoconstriction syndrome. Headache in pregnancy and the puerperium can be a cause of heightened anxiety in most women, who are concerned not only about the effect of the headache itself on the pregnancy but also about the effect of the treatment options on the pregnancy and the fetus. In this review, we discuss the latest literature on type and distribution of headaches during pregnancy and the postpartum period, and provide a digestible overview of the safety profile of commonly used abortive and prophylactic medications. We also discuss important considerations when treating migraine during menopause.
Acute Ischemic Stroke: A Review of Imaging, Patient Selection, and Management in the Endovascular Era. Part I: Initial Management and Imaging
Authors: Kumar G G Sharath , Nagesh Chinmay 
Published: December 2018

AbstractTill recently, the mainstay of management of acute ischemic stroke (AIS) has been intravenous thrombolysis. However, response to treatment and outcomes in the presence of a large vessel occlusion (LVO) were largely suboptimal. Endovascular thrombectomy techniques with stentrievers and aspiration catheters have revolutionized stroke treatment significantly, improving outcomes in this once untreatable disease. The interventional radiologist must play an active role in the stroke team in streamlining imaging as well as endovascular management. The focus of this review article is on initial management and imaging. Initial measures consist of patient resuscitation, basic investigations and assessment of stroke severity using the National Institutes of Health Stroke Scale (NIHSS), all of which have therapeutic and prognostic implications to be considered by the neurointerventionist. Imaging must aim to be swift and efficient. Choice of a modality must be based on available infrastructure as well as clinical-radiologic factors such as the time since ictus or posterior circulation involvement. Computed tomography (CT) is the preferred modality for its speed, whereas magnetic resonance imaging (MRI) remains the gold standard problem solving technique for detection of stroke. Exclusion of hemorrhagic stroke and other stroke mimics is the first objective. Thereafter, imaging is targeted toward assessing the parenchyma and vasculature. Defining the core and penumbra is the most important goal of parenchymal imaging. The core may be defined by the presence of early ischemic changes on CT, CT angiographic source images, or diffusion restriction on MRI. The penumbra is approximated by collateral status or perfusion methods. The prime directive of vascular imaging, either CT or magnetic resonance angiography (MRA) is to establish the presence of an LVO. Once confirmed, the decision for thrombolysis and/or thrombectomy is based on clinical and imaging criteria, the most ideal being that of a moderately severe stroke with a small core and LVO on imaging.
Objects and subjects in the left periphery
Authors: Belletti Adriana 
Published: December 2018

Abstract
A parallel is highlighted between the linguistic behavior of young Italian-speaking children as emerged in recent experimental work (Belletti and Manetti 2017) with comparative data from other Romance languages such as Balearic Catalan and (previous stages of) Spanish in the domain of a-Topics. A possible path from a-Topics to DOM is drawn, building on previous proposals in Belletti (2017a). a-Marking of topics concerns direct object DPs. A proposal is sketched out as to why subject DPs could not be a-marked when they are also topics in terms of a possibly conflicting requirement arising from the simultaneous satisfaction of both the Topic criterion with a-marking and the Subject criterion (in the sense of Rizzi 2006).
Dialects and neuroscience
Authors: Grimaldi Mirko 
Published: December 2018

Abstract
Dialectal variation has been constanly at the core of linguistic investigation. On the base of the few neurophysiological studies that explored dialectal data, this article examines if and how dialectal variation may contribute to the advancing of the neurobiology of language. Evidence suggest that the neural investigation of allophonic variation generated by phonological rules is very useful for the progress of the neurobiology of language. Also, all kinds of parametric variations characterizing dialects are well suited to this aim. Finally, I outline some general and detailed questions that need to be addressed making use of a new methodology: the oscillatory rhythms approach.
Novel pfkelch13 Gene Polymorphism Associates With Artemisinin Resistance in Eastern India
Authors: Das Sabyasachi , Manna Subhankar , Saha Bhaskar , Hati Amiya Kumar , Roy Somenath 
Published: December 2018

Abstract

Background
Artesunate-sulfadoxine-pyrimethamine (ASSP) is the frontline artemisinin combination therapy (ACT) in India. Random, irrational, subtherapeutic artemisinin doses and self-medication with ACT along with predominance of sulfadoxine-pyrimethamine resistance parasite invoked a strong possibility of emerging artemisinin-resistant malaria parasites.

Methods
This study involved 226 patients with uncomplicated Plasmodium falciparum infection who had successfully completed the 42 days follow-up after ASSP combination therapy from April 2014 to January 2016. We assessed the ASSP treatment efficacy by evaluating parasite clearance half-life, pfkelch13, and other (pfdhfr, pfdhps, pfmdr1, pfcrt) gene mutations and survival of parasites as detected by an ex vivo ring-stage survival assay (RSA).

Findings
Slow-clearing infections with longer parasite clearance half-lives (>5 hours) were observed in 12% isolates. Cure rate after ASSP treatment was declining to about 84.1%. ASSP failure was recorded in 15.9% (early treatment failure, 7.9%; late treatment failure, 7.9%) of isolates. In sum, 24 patients (10.6%) had parasite clearance half-lives greater than 5 hours with pfkelch13 polymorphism after 441 codon; in 15 of those patients (6.6%), parasites had not cleared by 72 hours after initiation of therapy. Median ex vivo ring-stage survival rate of these isolates was very high (12.2%; 95% confidence interval [CI], 10.9–13.8) from that of cured patients (0.9%; 95% CI, 0.09–1.07). Of these 15 patients, 13 patients had pfkelch13 G625R polymorphism, whereas 2 patients contained R539T polymorphism. As per the World Health Organization guideline, these 15 isolates were true artemisinin-resistant isolates.

Interpretation
Identification of artemisinin-resistant isolates in India together with new mutations and increasing combination therapy failures blow alarms for urgent malaria control.
Reproductive Homeostasis and Senescence in Drosophila melanogaster
Authors: Curtsinger James W 
Published: December 2018

Abstract
The homeostatic properties of reproduction in aging female Drosophila melanogaster are investigated. Classic studies based on cohort analysis suggest that homeostatic capacity declines gradually as daily oviposition rates decline in aging flies. Analysis at the level of individuals gives a very different picture: reproductive homeostasis remains relatively constant for most of adult life until a critical point when oviposition either ceases entirely or continues in dysregulated fashion. The collapse of homeostatic capacity is abrupt. Enhanced homeostasis is associated with increased lifetime fecundity and improved prospects for survival. The fractal concept of lacunarity can be used to parameterize the “roughness” of individual fecundity trajectories and is inversely related to homeostatic capacity.