bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-Resolution, Rapid-Scan Dual-Doppler Retrievals of Vertical Velocity in a Simulated Supercell
Authors: Dahl Nathan A. , Shapiro Alan , Potvin Corey K. , Theisen Adam , Gebauer Joshua G. , Schenkman Alexander D. , Xue Ming 
Published: May 2019

AbstractObservation system simulation experiments are used to evaluate different dual-Doppler analysis (DDA) methods for retrieving vertical velocity w at grid spacings on the order of 100 m within a simulated tornadic supercell. Variational approaches with and without a vertical vorticity equation constraint are tested, along with a typical (traditional) method involving vertical integration of the mass conservation equation. The analyses employ emulated radar data from dual-Doppler placements 15, 30, and 45 km east of the mesocyclone, with volume scan intervals ranging from 10 to 150 s. The effect of near-surface data loss is examined by denying observations below 1 km in some of the analyses. At the longer radar ranges and when no data denial is imposed, the “traditional” method produces results similar to those of the variational method and is much less expensive to implement. However, at close range and/or with data denial, the variational method is much more accurate, confirming results from previous studies. The vorticity constraint shows the potential to improve the variational analysis substantially, reducing errors in the w retrieval by up to 30% for rapid-scan observations (≤30 s) at close range when the local vorticity tendency is estimated using spatially variable advection correction. However, the vorticity constraint also degrades the analysis for longer scan intervals, and the impact diminishes with increased range. Furthermore, analyses using 30-s data also frequently outperform analyses using 10-s data, suggesting a limit to the benefit of increasing the radar scan rate for variational DDA employing the vorticity constraint.
Comparison of three infant venous reservoirs with vacuum-assisted venous drainage during varying levels of cardiotomy suction
Authors: Shade Brandon C , Melchior Richard W , Fisher Douglas R , High Robin , Mascio Christopher E , Rosenthal Tami M , Holt David W 
Published: May 2019

Background: Vacuum-assisted venous drainage has gained widespread use within the pediatric perfusion community for use during cardiopulmonary bypass. It is questioned whether its efficiency may be compromised with application of excessive cardiotomy suction to the infant hard-shell venous reservoir. An in vitro simulation circuit was used to research this phenomenon. A comparison of three different infant hard-shell venous reservoirs also took place to determine if one reservoir type was more advantageous when handling cardiotomy suction. The reservoirs tested were the Maquet VHK 11000, Medtronic Affinity Pixie, and Terumo Capiox FX05. Methods: The in vitro simulation circuit consisted of a 1 L reservoir bag that was cannulated at one access point with an Edwards Lifesciences 10Fr aortic cannula and the other access area with an Edwards Lifesciences 10Fr right angle venous cannula and 12Fr right angle venous cannula that were joined together. Key points of measurement and response variables were the pressures on the connection of the venous cannulas, inlet of the venous reservoir, and flow through the venous line. Vacuum was applied and manipulated with a Maquet VAVD Controller to settings of −20 mmHg, −30 mmHg, –40 mmHg, −50 mmHg, and −60 mmHg. Cardiotomy suction was added at settings of 1 LPM, 2 LPM, 3 LPM, and 4 LPM. Values from each response variable were monitored and recorded. These data were utilized to compare the reservoirs with a random coefficient model for each response variable. Conclusions: There is an adverse effect of excessive cardiotomy suction on the efficacy of vacuum-assisted venous drainage in infant hard-shell venous reservoirs. There is no significant difference between the VHK 11000, Pixie, and FX05 regarding their ability to handle this occurrence. An important discovery was that the FX05 showed a greater transfer of vacuum to the venous cannulas and reservoir inlet.
Autologous Freeze-Dried, Platelet-Rich Plasma Carrying Icariin Enhances Bone-Tendon Healing in a Rabbit Model
Authors: Zheng Cheng , Lu Hongbin , Tang Yifu , Wang Zhanwen , Ma Haozhe , Li Haixia , Chen Huabin , Chen Yang , Chen Can 
Published: May 2019

Background:Tendon-bone interface (TBI) injuries are common in sports activities. Owing to the limited regenerative ability of the TBI, its functional healing remains a difficulty in clinical practice. Icariin (ICA) provides strong stimulation for osteogenesis. Platelet-rich plasma (PRP) can be used as a carrier for bioactive molecules, although its ability to provide sustained release for such molecules needs improvement.Hypothesis:Freeze-dried PRP (FD-PRP) as a carrier for ICA can provide sustained release of ICA into the tendon-bone (T-B) healing site, thus accelerating T-B healing.Study Design:Controlled laboratory study.Methods:A total of 84 New Zealand rabbits with partial patellectomy in the hindlimb were randomly allocated into 3 different treatments: ICA incorporated with FD-PRP (ICA/FD-PRP), FD-PRP alone (FD-PRP), or saline control (CTL). The rabbit patella–patellar tendon (PP) interfaces were postoperatively harvested at postoperative week 8 or 16 for gross, radiological, histological, and mechanical evaluations.Results:Our results showed that FD-PRP can act as a carrier for sustained release of ICA into the T-B healing site. Macroscopically, no signs of infection or osteoarthritis were shown in the regenerated PP interfaces, and the area of cartilaginous metaplasia in the FD-PRP and ICA/FD-PRP groups at postoperative week 16 was significantly larger than that of the CTL group ( P < .05 for all). Radiologically, micro–computed tomography showed that new bone which formed at the healing site in the ICA/FD-PRP group was significantly increased, remodeled, and mineralized in comparison with the CTL group ( P < .05 for all). Histologically, the ICA/FD-PRP group exhibited a significant native PP interface, as shown by the enlargement and remodeling of new bone, well-organized collagen fibers, and robust production of proteoglycans in the regenerated fibrocartilage. The mechanical strength of the regenerated PP interface was significantly improved in the ICA/FD-PRP group. Significantly higher failure load and stiffness were shown in the ICA/FD-PRP group compared with the CTL and FD-PRP groups, respectively ( P < .05 for all).Conclusion:FD-PRP is a suitable sustained-release carrier for ICA, and ICA/FD-PRP can provide sustained release of ICA into the T-B healing site, thus effectively accelerating T-B healing.Clinical Relevance:Findings of this study demonstrate the feasibility of using FD-PRP as a carrier for ICA to improve T-B healing and provide a foundation for future clinical application.
A New Theory of Demand-Restricted Growth: The Basic Idea
Authors: Gries Thomas 
Published: May 2019

In mainstream theory, growth is explained fully by elements of the supply side. In this article, we depart from neoclassical mechanisms and suggest a hybrid approach that allows for growth restrictions induced by demand-side elements. We obtain such demand-restricted growth by suggesting an unconventional equilibrium concept in a stochastic environment. We define macroeconomic equilibrium as stationary no-expectation-error equilibrium. This equilibrium concept relates to the Nash idea of individual stationary behavior as long as expectations prove to be realized. No rigidities are introduced. Even if potential growth is generated by technical change and capital accumulation, the growth path is restricted by effective earnings and can be stable below the neoclassical path of potential growth. However, the growth process mutates to the neoclassical process if effective earnings and potential earnings equalize. Therefore, our hybrid model could help to bridge a gap between Keynesian and neoclassical ideas of economic growth. JEL Classifications: E12, E13, O40, E60
Prevalence and Risk Factors of Lower Reproductive Tract Infections in Symptomatic Women in Dakar, Senegal
Authors: Diadhiou Mohamed , Ba Diallo Awa , Barry Mamadou Saidou , Alavo Serge Covi , Mall Ibrahima , Gassama Omar , Ndiaye Guèye Mame Diarra , Ndao Fall Amy , Gawa Epainete , Gaye Diallo Aissatou , Moreau Jean Charles 
Published: May 2019

Background: Lower reproductive tract infections in women are important causes of morbidity but can also lead to complications and sequelae. This study aimed to establish the prevalence and risk factors of lower genital tract infections among women of reproductive age in Dakar (Senegal). Methods: This was a prospective study conducted in 6 maternity hospitals from July to November 2015. Participants ranged in age from 18 to 49 years and presented at health facilities with signs and symptoms of genital infection. Consenting individuals who met the inclusion criteria were recruited for the study. Results: During the reporting period, 276 patients were enrolled. According to the laboratory results, the prevalence of any genital infection was 69.6% (192 of 276). The most common vaginal infections were bacterial vaginosis (39.5%) and vaginal candidiasis (29%), with the third most common cause, trichomoniasis, trailing behind in terms of prevalence (2.5%). Among the microorganisms responsible for cervical infections, Ureaplasma urealyticum was the most frequent (27.5%), followed by Mycoplasma hominis (14.5%), Chlamydia trachomatis (4.7%), and Neisseria gonorrhoeae (1.1%). Multivariate analysis showed that young women and women with low levels of education were at increased risk for vaginal/cervical infections. Conclusions: This study revealed a high prevalence of bacterial vaginosis and vaginal candidiasis and suggests that health care providers should increase awareness and communication to improve vaginal hygiene practices. If infection with Trichomonas vaginalis, C trachomatis or N gonorrhoeae is suspected, we also recommend systematically performing laboratory diagnostic confirmation.
Home-based inspiratory muscle training for management of older patients with heart failure with preserved ejection fraction: does baseline inspiratory muscle pressure matter?
Authors: Palau Patricia , Domínguez Eloy , Ramón José María , López Laura , Briatore Antonio Ernesto , Tormo J Pablo , Ventura Bruno , Chorro Francisco J , Núñez Julio 
Published: May 2019

Background:Heart failure with preserved ejection fraction is a clinical syndrome characterised by reduced exercise capacity. Some evidence has shown that a simple and home-based programme of inspiratory muscle training offers promising results in terms of aerobic capacity improvement in patients with heart failure with preserved ejection fraction. This study aimed to investigate whether the baseline inspiratory muscle function predicts the changes in aerobic capacity (measured as peak oxygen uptake; peak VO2) after a 12-week home-based programme of inspiratory muscle training in patients with heart failure with preserved ejection fraction.Methods:A total of 45 stable symptomatic patients with heart failure with preserved ejection fraction and New York Heart Association II–III received a 12-week home-based programme of inspiratory muscle training between June 2015 and December 2016. They underwent cardiopulmonary exercise testing and measurements of maximum inspiratory pressure pre and post-inspiratory muscle training. Maximum inspiratory pressure and peak VO2were registered in both visits. Multivariate linear regression analysis was used to assess the association between changes in peak VO2(Δ-peakVO2) and baseline predicted maximum inspiratory pressure (pp-MIP).Results:The median (interquartile range) age was 73 (68–77) years, 47% were women and 35.6% displayed New York Heart Association III. The mean peak VO2at baseline and Δ-peakVO2post-training were 10.4±2.8 ml/min/kg and +2.2±1.3 ml/min/kg (+21.3%), respectively. The median (interquartile range) of pp-MIP and Δ-MIP were 71% (64–92) and 39.2 (26.7–80.4) cmH2O, respectively. After a multivariate analysis, baseline pp-MIP was not associated with Δ-peakVO2(β coefficient 0.005, 95% confidence interval −0.009–0.019, P=0.452).Conclusions:In symptomatic and deconditioned older patients with heart failure with preserved ejection fraction, a home-based inspiratory muscle training programme improves aerobic capacity regardless of the baseline maximum inspiratory pressure.
Oedema extension distance in intracerebral haemorrhage: Association with baseline characteristics and long-term outcome
Authors: Hurford Robert , Vail Andy , Heal Calvin , Ziai Wendy C , Dawson Jesse , Murthy Santosh B , Wang Xia , Anderson Craig S , Hanley Daniel F , Parry-Jones Adrian R ,   on behalf of the VISTA-ICH Collaborators
Published: May 2019

Introduction Oedema extension distance is a derived parameter that may reduce sample size requirements to demonstrate reduction in perihaematomal oedema in early phase acute intracerebral haemorrhage trials. We aimed to identify baseline predictors of oedema extension distance and its association with clinical outcomes. Patients and methods Using Virtual International Stroke Trials Archive-Intracerebral Haemorrhage, first Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial, and Minimally Invasive Surgery and rtPA for Intracerebral Hemorrhage Evacuation II datasets, we calculated oedema extension distance at baseline and at 72 h measured using computed tomography. Using linear regression, we tested for associations between baseline characteristics and oedema extension distance at 72 h. Ordinal regression (underlying assumptions validated) was used to test for associations between oedema extension distance at baseline and 72 h and oedema extension distance change between baseline and 72 h, and modified Rankin scale scores at 90 days, adjusted for baseline and 72 h prognostic factors. Results There were 1028 intracerebral haemorrhage cases with outcome data for analyses. Mean (standard deviation, SD) oedema extension distance at 72 h was 0.54 (0.26) cm, and mean oedema extension distance difference from baseline (EED72–0) was 0.24 (0.18) cm. Oedema extension distance at 72 h was greater with increasing baseline haematoma volume and baseline oedema extension distance. Increasing age, lobar haemorrhage, and intraventricular haemorrhage were independently associated with EED72–0. In multifactorial ordinal regression analysis, EED72–0 was associated with worse modified Rankin scale scores at 90 days (odds ratio 1.96, 95% confidence interval 1.00–3.82). Discussion Increase in oedema extension distance over 72 h is independently associated with decreasing functional outcome at 90 days. Oedema extension distance may be a useful surrogate outcome measure in early phase trials of anti-oedema or anti-inflammatory treatments in intracerebral haemorrhage.
RETRACTED ARTICLE: K-ras-ERK1/2 down-regulates H2A.XY142ph through WSTF to promote the progress of gastric cancer
Authors: Dong Chao , Sun Jing , Ma Sha , Zhang Guoying 
Published: May 2019

Abstract
Background
Histone H2AX phosphorylation at the site of Tyr-142 can participates in multiple biological progressions, which is including DNA repair. Ras pathway is closely involved in human cancers. Our study investigated the effects of Ras pathway via regulating H2AX.Y142ph.

Methods
Gastric cancer cell line SNU-16 and MKN1 cells were transfected with Ras for G12D and T35S site mutation. The phosphorylation of H2A.XY142 and ERK1/2, WSTF and MDM2 was detected by western blot. Cell viability, cell colonies and migration was analyzed by MTT assay, soft-agar colony formation assay, and Transwell assay, respectively. The expression of Ras pathway related downstream factors, EYA3 and WSTF was detected by qRT-PCR. The relationship between Ras and downstream factors were detected by ChIP. The cell cycle progression was measured by flow cytometry.

Results
RasG12D/T35V transection decreased the phosphorylation of H2A.XY142 and activated phosphorylation of ERK-1/2. H2A.XY142 inhibited cell viability, colonies and migration. H2A.XY142ph altered the expression of Ras downstream factors. CHIP assay revealed that RasG12D/T35V could bind to the promoters of these Ras pathway downstream factors. Silence of EYA3 increased H2A.XY142ph and inhibited cell viability, migration and percent cells in S stage. Furthermore, silence of EYA3 also changed the downstream factors expression. WSTF and H2A.XY142ph revealed the similar trend and MDM2 on the opposite.

Conclusion
Ras/ERK signal pathway decreased H2A.XY142ph and promoted cell growth and metastasis. This Ras regulation process was down-regulated by the cascade of MDM2-WSTF-EYA3 to decrease H2A.XY142ph in SNU-16 cells.
Transformation from total-field magnetic anomaly to the projection of the anomalous vector onto the normal geomagnetic field based on an optimization method
Authors: Zhen Huixiang , Li Yuanyuan , Yang Yushan 
Published: May 2019

The total-field magnetic anomaly [Formula: see text] is approximated as the component [Formula: see text] of the anomalous vector [Formula: see text] along the direction of the normal geomagnetic field. It is widely used in magnetic data processing and interpretation practices as a routine if [Formula: see text] is relatively small. But in highly magnetic environments, the distinction between [Formula: see text] and [Formula: see text] is often too large to be ignored. We carefully investigate the difference between [Formula: see text] and [Formula: see text] and find that it will increase rapidly in the trend of the quadratic function as [Formula: see text] strengthens. We also test the effects of approximation on the component transformation and reduction to the pole on a synthetic single-sphere model. As expected, the error caused by inaccurate information will propagate into subsequent data processing procedures and adversely affect the results. Therefore, we have developed an optimization strategy based on the limited-memory Broyden-Fletcher-Goldfarb-Shanno (L-BFGS) algorithm to transform the total-field anomaly into [Formula: see text]. First, we have constructed an objective function after transforming [Formula: see text] into [Formula: see text] through the component transformation in the frequency domain. Then, using [Formula: see text] as the initial value of [Formula: see text], [Formula: see text] is calculated iteratively by the L-BFGS algorithm. To test the validity of the optimization algorithm, [Formula: see text] is transformed for noise-free and noise-corrupted models and models with a background field. The synthetics indicate that the transformed [Formula: see text] is almost the same as the model [Formula: see text], whose maximum error is approximately one-hundredth (30 nT) of the difference (8000 nT) between the modeled [Formula: see text] and [Formula: see text]. The synthetics and field data example from the Yangshan Iron Mine, Fujian Province, southern China, also indicate that the data transformation and forward-modeling results can benefit from the direct use of transformed [Formula: see text] instead of [Formula: see text].
Effectiveness of Lung Cancer Screening Implementation in the Community Setting in the United States
Authors: Copeland Amy , Criswell Angela , Ciupek Andrew , King Jennifer C. 
Published: May 2019

PURPOSE: The National Lung Screening Trial demonstrated a 20% relative reduction in lung cancer mortality with low-dose computed tomography screening, leading to implementation of lung cancer screening across the United States. The Centers for Medicare and Medicaid Services approved coverage, but questions remained about effectiveness of community-based screening. To assess screening implementation during the first full year of CMS coverage, we surveyed a nationwide network of lung cancer screening centers, comparing results from academic and nonacademic centers. METHODS: One hundred sixty-five lung cancer screening centers that have been designated Screening Centers of Excellence responded to a survey about their 2016 program data and practices. The survey included 21 pretested, closed- and open-ended quantitative and qualitative questions covering implementation, workflow, numbers of screening tests completed, and cancers diagnosed. RESULTS: Centers were predominantly community based (62%), with broad geographic distribution. In both community and academic centers, more than half of lung cancers were diagnosed at stage I or limited stage, demonstrating a clear stage shift compared with historical data. Lung-RADS results were also comparable. There are wide variations in the ways centers address Centers for Medicare and Medicaid Services requirements. The most significant barriers to screening implementation were insurance and billing issues, lack of provider referral, lack of patient awareness, and internal workflow challenges. CONCLUSION: These data validate that responsible screening can take place in a community setting and that lung cancers detected by low-dose computed tomography screening are often diagnosed at an early, more treatable stage. Lung cancer screening programs have developed different ways to address requirements, but many implementation challenges remain.
Spin Seebeck effect in polycrystalline yttrium iron garnet pellets prepared by the solid-state method
Authors: Venkat G. , Rose T. A. , Cox C. D. W. , Stenning G. B. G. , Caruana A. J. , Morrison K. 
Published: May 2019

Abstract
We study the properties of polycrystalline bulk yttrium iron garnet (YIG) pellets prepared by the solid-state method, where the choice of the sintering temperature can lead to mixed phases of yttrium iron perovskite (YIP) and YIG or single phase YIG. Magnetometry shows multiple switching regimes in the mixed-phase pellets where the saturation magnetization is dominated by the proportion of YIG present. Ferromagnetic resonance was used to corroborate the saturation magnetization from magnetometry and to extract the spin wave damping α. The lowest damping was observed for the YIG pellet, which resulted in a spin Seebeck effect (SSE) coefficient that was approximately 55% of single crystal YIG. This demonstrates that macroscale crystallization does not play a major role in the SSE and paves the way for utilising polycrystalline samples for thermomagnetic applications.
Path integration: how details of the honeybee waggle dance and the foraging strategies of desert ants might help in understanding its mechanisms
Authors: Collett Thomas S. 
Published: May 2019

ABSTRACTPath integration is a navigational strategy that gives an animal an estimate of its position relative to some starting point. For many decades, ingenious and probing behavioural experiments have been the only window onto the operation of path integration in arthropods. New methods have now made it possible to visualise the activity of neural circuits in Drosophila while they fly or walk in virtual reality. Studies of this kind, as well as electrophysiological recordings from single neurons in the brains of other insects, are revealing details of the neural mechanisms that control an insect's direction of travel and other aspects of path integration. The aim here is first to review the major features of path integration in foraging desert ants and honeybees, the current champion path integrators of the insect world, and second consider how the elaborate behaviour of these insects might be accommodated within the framework of the newly understood neural circuits. The discussion focuses particularly on the ability of ants and honeybees to use a celestial compass to give direction in Earth-based coordinates, and of honeybees to use a landscape panorama to provide directional guidance for path integration. The possibility is raised that well-ordered behaviour might in some cases substitute for complex circuitry.