bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical outcomes and risk factors of thromboprophylaxis with rivaroxaban versus aspirin in patients undergoing hip arthroplasty in low‐incidence population: A nationwide study in Korea
Authors: Kim Hong Ah , Lee Ju‐Yeun , Park So Hyun , Kang JiEun , Choi Kyung Suk , Rhie Sandy Jeong 
Published: March 2019

AbstractPurposeWe aimed to evaluate the efficacy and safety of rivaroxaban in thromboprophylaxis compared with those of aspirin in real‐world patients who underwent hip arthroplasty using nationwide claims data.MethodsPatients aged more than or equal to 18 years with at least one hip arthroplasty including total and partial hip replacements and hip replacement revisions during July 2009 to June 2013 were identified from the Health Insurance Review and Assessment (HIRA) database. The study outcome was incidence rate of thromboembolic events and anticoagulation‐related major bleeding within 90 days of hip arthroplasty.ResultsThe incidence of overall venous thromboembolism (VTE) within 90‐day postsurgery was significantly higher in the aspirin cohort than it was in the rivaroxaban cohorts. Bleeding events associated with pharmacological thromboprophylaxis in patients who received rivaroxaban were not significantly different from that in aspirin‐treated patients. In aspirin cohorts, 65.7% of patients received less than 3‐week treatment while about half received a less than 14‐day treatment, and 31.7% received more than 3‐week treatment in the rivaroxaban cohort.ConclusionsThis study demonstrates that rivaroxaban was more effective in preventing VTE following hip arthroplasty without raising bleeding risks in clinical settings. Age more than or equal to 80 years, women, and a history of thromboembolism were the risk factors of VTE incidence.
Teacher–student relationships, psychological need satisfaction, and happiness among diverse students
Authors: Froiland John Mark , Worrell Frank C. , Oh Hyejeong 
Published: March 2019

AbstractTeacher–student relationships have been linked to autonomous motivation and achievement. However, relatively little is known about whether satisfying students’ psychological needs mediates the association between teacher–student relationships and student happiness. Furthermore, this relationship needs to be examined in samples of students from different ethnic and racial backgrounds. In this structural equation modeling study (N = 1,961), we found that teacher–student relationships were positively and moderately associated with the satisfaction of psychological needs for autonomy, relatedness, and competence. Satisfying psychological needs, in turn, was moderately positively associated with happiness. These findings held across African American, Asian American, and Latinx subsamples. For the overall sample, students in higher grade levels perceived that their psychological needs were met to a lesser degree than students in earlier grades. However, only the Latinx subsample replicated this effect. Teacher–student relationships may promote happiness via meeting psychological needs.
Improved mental health among LABILE study participants: A qualitative exploration
Authors: Sanatinia Rahil , Afzal Samir , MacLaren Thomas , McNulty Antoinette , Adele Claudia , Morah Ayodeji , Crawford Mike 
Published: March 2019

AbstractResults of the LABILE trial showed no difference between people with BPD who were prescribed lamotrigine and those on placebo. However, most study participants experienced sustained improvement in their mental health during the trial. We conducted a thematic analysis of qualitative data from interviews with 47 LABILE study participants to identify factors that may have contributed to this improvement. We identified three main themes: initial reasons and expectations regarding trial participation, patients' experiences of the trial and areas of change. Reasons for participating in the trial included a search for consistent and stable professional care as well as altruistic motives. Improvements in symptoms over the course of the trial were explained by several factors including consistency provided by the research team, salience of the social context and the availability of alternative support networks. While participants appreciated the autonomy provided by the voluntary nature of the trial, they felt that improvements stemmed from the ‘structure’ brought about by their actively engaging in the study. This study highlights the importance of clear and transparent communication when treating people with BPD. Mental health professionals should ensure that services for people with BPD are consistent and structured. © 2019 John Wiley & Sons, Ltd.
Mouse genetic background impacts susceptibility to hyperoxia‐driven perturbations to lung maturation
Authors: Tiono Jennifer , Surate Solaligue David E , Mižíková Ivana , Nardiello Claudio , Vadász István , Böttcher‐Friebertshäuser Eva , Ehrhardt Harald , Herold Susanne , Seeger Werner , Morty Rory E 
Published: March 2019

AbstractBackgroundThe laboratory mouse is widely used in preclinical models of bronchopulmonary dysplasia, where lung alveolarization is stunted by exposure of pups to hyperoxia. Whether the diverse genetic backgrounds of different inbred mouse strains impacts lung development in newborn mice exposed to hyperoxia has not been systematically assessed.MethodsHyperoxia (85% O2, 14 days)‐induced perturbations to lung alveolarization were assessed by design‐based stereology in C57BL/6J, BALB/cJ, FVB/NJ, C3H/HeJ, and DBA/2J inbred mouse strains. The expression of components of the lung antioxidant machinery was assessed by real‐time reverse transcriptase polymerase chain reaction and immunoblot.ResultsHyperoxia‐reduced lung alveolar density in all five mouse strains to different degrees (C57BL/6J, 64.8%; FVB/NJ, 47.4%; BALB/cJ, 46.4%; DBA/2J, 45.9%; and C3H/HeJ, 35.9%). Hyperoxia caused a 94.5% increase in mean linear intercept in the C57BL/6J strain, whilst the C3H/HeJ strain was the least affected (31.6% increase). In contrast, hyperoxia caused a 65.4% increase in septal thickness in the FVB/NJ strain, where the C57BL/6J strain was the least affected (30.3% increase). The expression of components of the lung antioxidant machinery in response to hyperoxia was strain dependent, with the C57BL/6J strain exhibiting the most dramatic engagement. Baseline expression levels of components of the lung antioxidant systems were different in the five mouse strains studied, under both normoxic and hyperoxic conditions.ConclusionThe genetic background of laboratory mouse strains dramatically influenced the response of the developing lung to hyperoxic insult. This might be explained, at least in part, by differences in how antioxidant systems are engaged by different mouse strains after hyperoxia exposure.
Tisagenlecleucel Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor–T Cells
Authors: Stein Andrew M. , Grupp Stephan A. , Levine John E. , Laetsch Theodore W. , Pulsipher Michael A. , Boyer Michael W. , August Keith J. , Levine Bruce L. , Tomassian Lori , Shah Sweta , Leung Mimi , Huang Pai‐Hsi , Awasthi Rakesh , Mueller Karen Thudium , Wood Patricia A. , June Carl H. 
Published: March 2019

Tisagenlecleucel is a chimeric antigen receptor–T cell therapy that facilitates the killing of CD19+ B cells. A model was developed for the kinetics of tisagenlecleucel and the impact of therapies for treating cytokine release syndrome (tocilizumab and corticosteroids) on expansion. Data from two phase II studies in pediatric and young adult relapsed/refractory B cell acute lymphoblastic leukemia were pooled to evaluate this model and evaluate extrinsic and intrinsic factors that may impact the extent of tisagenlecleucel expansion. The doubling time, initial decline half‐life, and terminal half‐life for tisagenlecleucel were 0.78, 4.3, and 220 days, respectively. No impact of tocilizumab or corticosteroids on the expansion rate was observed. This work represents the first mixed‐effect model‐based analysis of chimeric antigen receptor–T cell therapy and may be clinically impactful as future studies examine prophylactic interventions in patients at risk of higher grade cytokine release syndrome and the effects of these interventions on chimeric antigen receptor–T cell expansion.
Effects of quercetin supplementation on glycemic control among patients with metabolic syndrome and related disorders: A systematic review and meta‐analysis of randomized controlled trials
Authors: Ostadmohammadi Vahidreza , Milajerdi Alireza , Ayati Elnaz , Kolahdooz Fariba , Asemi Zatollah 
Published: March 2019

This systematic review and meta‐analysis of randomized controlled trials was performed to determine the effect of quercetin supplementation on glycemic control among patients with metabolic syndrome and related disorders. Databases including PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials were searched until August 30, 2018. Nine studies with 10 effect sizes out of 357 selected reports were identified eligible to be included in current meta‐analysis. The pooled findings indicated that quercetin supplementation did not affect fasting plasma glucose (FPG), homeostasis model of assessment‐estimated insulin resistance, and hemoglobin A1c levels. In subgroup analysis, quercetin supplementation significantly reduced FPG in studies with a duration of ≥8 weeks (weighted mean difference [WMD]: −0.94; 95% confidence interval [CI; −1.81, −0.07]) and used quercetin in dosages of ≥500 mg/day (WMD: −1.08; 95% CI [−2.08, −0.07]). In addition, subgroup analysis revealed a significant reduction in insulin concentrations following supplementation with quercetin in studies that enrolled individuals aged <45 years (WMD: −1.36; 95% CI [−1.76, −0.97]) and that used quercetin in dosages of ≥500 mg/day (WMD: −1.57; 95% CI [−1.98, −1.16]). In summary, subgroup analysis based on duration of ≥8 weeks and used quercetin in dosages of ≥500 mg/day significantly reduced FPG levels.
Maximal feedback linearization and its internal dynamics with applications to mechanical systems on
Authors: Li Shunjie , Moog Claude H. , Respondek Witold 
Published: March 2019

SummaryFor systems that are not feedback linearizable, a natural question is: how to find the largest feedback linearizable subsystem and, if the partial linearization is not unique, what are the control‐theoretic properties of various partial linearizations. In this paper, we will consider the problem of how to choose a partially linearizing output that renders the zero dynamics asymptotically stable and when such an output exists. We will state general results solving completely the problem for systems whose linearizability defect is one by identifying and describing two classes of systems. For the first class, all maximal partial linearizations lead to the same zero dynamics. For the second class, any asymptotic behavior of the zero dynamics can be achieved by a suitable choice of a partially linearizing output. In the second part, we apply our results to mechanical systems with two‐degrees‐of‐freedom and provide a detailed study of their partial linearizations. We illustrate the obtained results by examples of Acrobot (which belongs to the second class) and Pendubot (which belongs to the first class).
An eutrophication index for lowland sandy rivers in Mediterranean coastal climatic regions of Southern Africa
Authors: Oberholster Paul J. , Madlala Tebogo , Blettler Martin César Maria , Amsler Mario L. , Eberle Eliana G. , Botha Anna‐Maria 
Published: March 2019

AbstractThe eutrophication of waterways has become an endemic global problem. Nutrient enrichment from agriculture activities and waste water treatment plants are major drivers, but it remains unclear how lowland sandy rivers respond to eutrophication. The objective of this study was the development and verification of eutrophication index for sandy rivers (EISR) to prioritize nutrient enrichment river stretches caused by different land use activities that include point and nonpoint sources of nutrient enrich water. The Berg River drainage system in South Africa served as a case study area for this purpose during the dry seasons (December and January) of 2015 and 2016. In the initial EISR development phase, periphyton, benthic biomass (chl‐a mg m−2), and macroinvertebrate families were employed as benthic bioindicators of river bedforms, whereas in the second phase, physicochemical and abiotic variables were used as target indicator. Using a weight of support approach, the site receiving sewage effluent was categorize as heavily polluted whereas sites impacted by agriculture land use activities were polluted. The EISR that focuses strongly on benthic bioindicators, which are close to the transfer of nutrients and energy in the food web, showed a distinct difference between river bedform impacted by sewage effluent and agriculture none point source. A maximum benthic algae biomass of 110 mg m−2 chl‐a was recorded with higher sediment orthophosphate concentration at sewage‐impacted sites. The outcome of the proposed EISR showed that it can be employed as a decision support tool for eutrophication management of sandy rivers.
Mannich Bases of 1,2,4‐Triazolones as Potent Anti‐Tubercular and Antifungal Agents
Authors: Dorababu Atukuri , Kamble Ravindra R. , Kamble Atulkumar A. , Kumbar Mahadev N. , Shaikh SabaKauser J. , Netalkar Sandeep P. 
Published: March 2019

AbstractArylsydnone 1 a‐b is ring transformed to 1,3,4‐oxadiazole 2 a‐b and further converted to 1,2,4‐triazolones 3 a‐b. Condensation of compound 3 a‐b with aromatic aldehydes followed by reduction yielded a secondary amine derivative 5 a‐d. Subsequent reaction of compound 5 a‐d with formaldehyde and various secondary amines in presence of an acid catalyst afforded mannich bases 6 a‐p. Single crystals of the intermediate compounds (Schiff bases) 4 a and 4 b are obtained and confirmed by x‐ray crystallographic studies. All the final compounds are tested for anti‐tubercular and anti‐fungal activity. Almost all compounds have exhibited good pharmacological activity. In anti‐tubercular activity, especially compounds 6 d and 6 f have shown excellent activities at the drug concentrations 3.12 μg/ml and 6.25 μg/ml respectively. While in antifungal activity against C. albicans, compounds 6 d and 6 m have exhibited good activities at the drug concentrations 6.25 μg/ml and 12.50 μg/ml where as in the antifungal activity against A. fumigatus, only the compounds 6 b and 6 g have exhibited promising activity at the drug concentration 0.20 μg/ml.
Recent Progress in Multivalent Metal (Mg, Zn, Ca, and Al) and Metal‐Ion Rechargeable Batteries with Organic Materials as Promising Electrodes
Authors: Xie Jian , Zhang Qichun 
Published: March 2019

AbstractThe emerging demand for electronic and transportation technologies has driven the development of rechargeable batteries with enhanced capacity storage. Especially, multivalent metal (Mg, Zn, Ca, and Al) and metal‐ion batteries have recently attracted considerable interests as promising substitutes for future large‐scale energy storage devices, due to their natural abundance and multielectron redox capability. These metals are compatible with nonflammable aqueous electrolytes and are less reactive when exposed in ambient atmosphere as compared with Li metals, hence enabling potential safer battery systems. Luckily, green and sustainable organic compounds could be designed and tailored as universal host materials to accommodate multivalent metal ions. Considering these advantages, effective approaches toward achieving organic multivalent metal and metal‐ion rechargeable batteries are highlighted in this Review. Moreover, organic structures, cell configurations, and key relevant electrochemical parameters are presented. Hopefully, this Review will provide a fundamental guidance for future development of organic‐based multivalent metal and metal‐ion rechargeable batteries.
Additive‐Assisted Novel Dual‐Salt Electrolyte Addresses Wide Temperature Operation of Lithium–Metal Batteries
Authors: Shangguan Xuehui , Xu Gaojie , Cui Zili , Wang Qinglei , Du Xiaofan , Chen Kai , Huang Suqi , Jia Guofeng , Li Faqiang , Wang Xiao , Lu Di , Dong Shanmu , Cui Guanglei 
Published: March 2019

AbstractIn this study, self‐synthesized lithium trifluoro(perfluoro‐tert‐butyloxyl)borate (LiTFPFB) is combined with lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) to formulate a novel 1 m dual‐salt electrolyte, which contains lithium difluorophosphate (LiPO2F2) additive and dominant carbonate solvents with low melting point and high boiling point. The addition of LiPO2F2 into this novel dual‐salt electrolyte dramatically improves cycleability and rate capability of a LiNi0.5Mn0.3Co0.2O2/Li (NMC/Li) battery, ranging from −40 to 90 °C. The NMC/Li batteries adopt a Li–metal anode with low thickness of 100 µm (even 50 µm) and a moderately high cathode mass loading level of 10 mg cm−2. For the first time, this paper provides valuable perspectives for developing practical lithium–metal batteries over a wide temperature range.
Flood Risk and Salience: New Evidence from the Sunshine State
Authors: Bakkensen Laura A. , Ding Xiaozhou , Ma Lala 
Published: March 2019

A growing literature finds evidence that flood risk salience varies over time, spiking directly following a flood and then falling off individuals' cognitive radar in the following years. In this article, we provide new evidence of salience exploiting a hurricane cluster impacting Florida that was preceded and followed by periods of unusual calm. Utilizing residential property sales across the state from 2002 through 2012, our main estimate finds a salience impact of −8%, on average. The salience effect persists when we base estimation only on spatial variation in prices to limit confounding from other simultaneous changes due to shifting hedonic equilibria over time. These effects range from housing prices decreases of 5.4–12.3% depending on the year of sale. Understanding flood risk salience has important implications for flood insurance and disaster policy, the benefits transfer literature, and, more broadly, our understanding of natural disaster resilience.JEL Classification: Q51, Q54, R21
Net pressure and correlation characteristics between internal and external pressures for tall building with opening
Authors: Wang Xu , Qian Yuanhao , Yu Xianfeng , Xie Zhuangning 
Published: March 2019

SummaryNet pressure and correlation characteristics between internal and external pressures for a typical high‐rise building with a dominant opening are detailed investigated by a series of wind tunnel experiments on a scaled rigid model. The experimental results show that internal pressures are absolutely spatially relevant. When the dominant opening faces to approaching wind, there exists strong positive correlation between internal and external pressures of each tap on the windward wall, whereas negative correlation can be observed for each tap on the other walls. At the wind directions of 15° and 75°, the highest negative correlation coefficient occurs on the right side wall and is up to −0.6 and the mean values of area‐averaged net pressure coefficient on the right side wall also reach their maximum and minimum values, respectively; meanwhile, the values of standard deviation of area‐averaged net pressure coefficient are also much higher. Thus, it should be paid more attention to the wind‐resistant design of side wall envelopes because they are easier to be destroyed.
Evaluating the fate of bacterial indicators, viral indicators, and viruses in water resource recovery facilities
Authors: Worley‐Morse Thomas , Mann Melanie , Khunjar Wendell , Olabode Lola , Gonzalez Raul 
Published: March 2019

AbstractA year‐long sampling campaign at nine water resource recovery facilities (WRRFs) was conducted to assess the treatability and fate of bacterial indicators, viral indicators, and viruses. Influent concentrations of viral indicators (male‐specific and somatic coliphages) and bacterial indicators (Escherichia coli and enterococci) remained relatively constant, typically varying by one order of magnitude over the course of the year. Annual average bacterial indicator reduction ranged from 4.0 to 6.7 logs, and annual average viral indicator reduction ranged from 1.6 to 5.4 logs. Bacterial and viral indicator reduction depended on the WRRF's treatment processes, and bacterial indicator reduction was greater than viral indicator reduction for many processes. Viral reduction (adenovirus 41, norovirus GI, and norovirus GII) was more similar to viral indicator reduction than bacterial indicator reduction. Overall, this work suggests that viral indicator reduction in WRRFs is variable and depends on specific unit processes. Moreover, for the same unit treatment process, viral indicator reduction and bacterial indicator reduction can vary.Practitioner points

A year‐long sampling campaign was conducted at nine water resource recovery facilities (WRRFs).

The treatability and fate of bacterial indicators, viral indicators, and viruses were assessed.

Viral indicator reduction in WRRFs is variable and depends on specific unit processes.

For the same unit treatment process, viral indicator reduction and bacterial indicator reduction can vary.
Enhancing photocatalytic degradation of methyl orange by crystallinity transformation of titanium dioxide: A kinetic study
Authors: Adnan Fahrizal , Phattarapattamawong Songkeart 
Published: March 2019

AbstractThis work aimed to enhance the photocatalytic degradation of methyl orange (MO) by crystallinity transformation of titanium dioxide (TiO2). In addition, the kinetic degradation of MO was determined. To transform its crystallinity, TiO2 was synthesized using a sol–gel method and calcined at between 200°C to 600°C. Calcination at a temperature of 250°C resulted in TiO2 that showed the best performance, corresponding to MO removal of 87% ± 7%. MO removal by TiO2 calcined between 250°C to 400°C was higher than for commercial TiO2 powder (Sigma‐aldrich) (62% ± 4%). TiO2 with a small crystallite size and high anatase fraction enhanced the photocatalytic degradation of MO, while the specific surface area and surface roughness seemed to play a minor role. The photocatalytic degradation of MO was NaCl‐independent, while the photocatalytic activity increased with decreased pH. Reused TiO2 showed similar photocatalytic degradation of MO compared with pristine TiO2, at 84 ± 2%. The oxidation kinetics of TiO2 calcined at 250°C were fitted to the Langmuir–Hinshelwood model (R2 = 0.9134). The kr and Ks values were 0.027 mg L−1 min−1 and 0.621 L/mg, respectively. Crystallinity transformation was a major factor in the enhancement of photocatalytic degradation of MO.Practitioner points

Photocatalytic activity of TiO2 depends on calcination temperature, pH, and a number of UVC lamps.

TiO2 with a small crystallite size and high anatase fraction enhanced the photocatalytic degradation of MO.