bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silencing long non‐coding RNA MEG3 accelerates tibia fraction healing by regulating the Wnt/β‐catenin signalling pathway
Authors: Liu Yu‐Bao , Lin Lu‐Pan , Zou Rui , Zhao Qing‐Hua , Lin Fu‐Qing 
Published: April 2019

AbstractAs fracture healing is related to gene expression, fracture healing is prospected to be implicated in long non‐coding RNAs (lncRNAs). This study focuses on the effects of epigenetic silencing of long non‐coding RNA maternally expressed gene 3 (lncRNA MEG3) on fracture healing by regulating the Wnt/β‐catenin signalling pathway. Genes expressed in fracture were screened using bioinformatics and the subcellular location of MEG3 was determined using FISH. Next, we successfully established tibia fracture (TF) models of C57BL/6J and Col2a1‐ICAT mice and the effect of silencing lncRNA MEG3 on fracture healing was detected after TF mice were treated with phosphate buffer saline (PBS), MEG3 siRNA and scramble siRNA. X‐ray imaging, Safranin‐O/fast green and haematoxylin‐eosin (HE) staining and histomorphometrical and biomechanical analysis were adopted to observe and to detect the fracture healing conditions. Additionally, the positive expression of collagen II and osteocalcin was examined using immunohistochemistry. At last, in the in vitro experiment, the relationship of MEG3 and the Wnt/β‐catenin signalling pathway in fraction healing was investigated. MEG3 was located in the cell nucleus. In addition, it was found that MEG3 and the Wnt/β‐catenin signalling pathway were associated with fraction healing. Moreover, silencing MEG3 was proved to elevate callus area and maximum bending load and to furthermore enhance the recanalization of bone marrow cavity. Finally, MEG3 knockdown elevated levels of Col10a1, Runx2, Osterix, Osteocalcin, Wnt10b and β‐catenin/β‐catenin whereas it reduced p‐GSK‐3β/GSK‐3β levels. Taken together, our data supported that epigenetic silencing of lncRNA MEG3 could promote the tibia fracture healing by activating the Wnt/β‐catenin signalling pathway.
RBM10 inhibits cell proliferation of lung adenocarcinoma via RAP1/AKT/CREB signalling pathway
Authors: Jin Xin , Di Xin , Wang Ruimin , Ma He , Tian Chang , Zhao Min , Cong Shan , Liu Jiaying , Li Ranwei , Wang Ke 
Published: April 2019

AbstractInitial functional studies have demonstrated that RNA‐binding motif protein 10 (RBM10) can promote apoptosis and suppress cell proliferation; however, the results of several studies suggest a tumour‐promoting role for RBM10. Herein, we assessed the involvement of RBM10 in lung adenocarcinoma cell proliferation and explored the potential molecular mechanism. We found that, both in vitro and in vivo, RBM10 overexpression suppresses lung adenocarcinoma cell proliferation, while its knockdown enhances cell proliferation. Using complementary DNA microarray analysis, we previously found that RBM10 overexpression induces significant down‐regulation of RAP1A expression. In this study, we have confirmed that RBM10 decreases the activation of RAP1 and found that EPAC stimulation and inhibition can abolish the effects of RBM10 knockdown and overexpression, respectively, and regulate cell growth. This effect of RBM10 on proliferation was independent of the MAPK/ERK and P38/MAPK signalling pathways. We found that RBM10 reduces the phosphorylation of CREB via the AKT signalling pathway, suggesting that RBM10 exhibits its effect on lung adenocarcinoma cell proliferation via the RAP1/AKT/CREB signalling pathway.
PTPN2 improved renal injury and fibrosis by suppressing STAT‐induced inflammation in early diabetic nephropathy
Authors: Li Ya , Zhou Huimin , Li Yulin , Han Lu , Song Ming , Chen Fangfang , Shang Guokai , Wang Di , Wang Zhihao , Zhang Wei , Zhong Ming 
Published: April 2019

AbstractDiabetic nephropathy (DN) is a chronic inflammatory disease triggered by disordered metabolism. Recent studies suggested that protein tyrosine phosphatase non‐receptor type 2 (PTPN2) could ameliorate metabolic disorders and suppress inflammatory responses. This study investigated PTPN2's role in modulating DN and the possible cellular mechanisms involved. In a mouse model combining hyperglycaemia and hypercholesterolaemia (streptozotocin diabetic, ApoE‐/‐ mice), mice showed severe insulin resistance, renal dysfunction, micro‐inflammation, subsequent extracellular matrix expansion and decreased expression of PTPN2. We found that mice treated with PTPN2 displayed reduced serum creatinine, serum BUN and proteinuria. PTPN2 gene therapy markedly attenuated metabolic disorders and hyperglycaemia. In addition, PTPN2 gene transfer significantly suppressed renal activation of signal transducers and activators of transcription (STAT), STAT‐dependent pro‐inflammatory and pro‐fibrotic genes expression, and influx of lymphocytes in DN, indicating anti‐inflammatory effects of PTPN2 by inhibiting the activation of STAT signalling pathway in vivo. Furthermore, PTPN2 overexpression inhibited the high‐glucose induced phosphorylation of STAT, target genes expression and proliferation in mouse mesangial and tubuloepithelial cells, suggesting that the roles of PTPN2 on STAT activation was independent of glycaemic changes. Our results demonstrated that PTPN2 gene therapy could exert protective effects on DN via ameliorating metabolic disorders and inhibiting renal STAT‐dependent micro‐inflammation, suggesting its potential role for treatment of human DN.
Plagiarism in Predatory Publications: A Comparative Study of Three Nursing Journals
Authors: Owens Jacqueline K. , Nicoll Leslie H. 
Published: April 2019

AbstractPurposeThis study compared three known predatory nursing journals to determine the percentage of content among them that was plagiarized or duplicated. A serendipitous finding of several instances of plagiarism via duplicate publications during the random analysis of articles in a study examining the quality of articles published in predatory journals prompted this investigation.DesignThe study utilized a descriptive, comparative design. All articles in each journal (n = 296 articles) from inception (volume 1, number 1) through May 1, 2017, were analyzed.MethodsEach article was evaluated and scored electronically for similarity using an electronic plagiarism detection tool. Articles were then individually reviewed, and exact and near exact matches (90% or greater plagiarized content) were paired. Articles with less than 70% plagiarized scores were randomly sampled, and an in‐depth search for matches of partial content in other journals was conducted. Descriptive statistics were used to summarize the data.FindingsThe extent and direction of duplication from one given journal to another was established. Changes made in subsequent publications, as a potential distraction to identify plagiarism, were also identified. There were 100 (68%) exact and near exact matches in the paired articles. The time lapse between the original and duplicate publication ranged from 0 to 63 months, with a mean of 27.2 months (SD =19.68). Authors were from 26 countries, including Africa, the United States, Turkey, and Iran. Articles with similarity scores in the range of 20% to 70% included possible similarities in content or research plagiarism, but not to the extent of the exact or near exact matches. The majority of the articles (n = 94) went from Journal A or C to Journal B, although four articles were first published in Journal B and then Journal A.ConclusionsThis study found a substantial level of plagiarism via duplicate publications in the three analyzed predatory journals, further diluting credible scientific literature and risking the ability to synthesize evidence accurately to inform practice. Editors should continue to use electronic plagiarism detection tools. Education about publishing misconduct for editors and authors is a high priority.Clinical RelevanceBoth contributors and consumers of nursing literature rely on integrity in publication. Authors expect appropriate credit for their scholarly contributions without unethical and unauthorized duplication of their work. Readers expect current information from original authors, upon which they can make informed practice decisions.
The evaluation of elasticity after nonablative radiofrequency rejuvenation
Authors: Erkiert‐Polguj Anna , Algiert‐Zielinska Barbara , Zdunska Kamila , Markiewicz Agata , Skubalski Janusz , Rotsztejn Helena 
Published: April 2019

SummaryBackgroundLaxity and rhytides are manifestations of photodamage on the face and chest. Nonablative radiofrequency (RF) is one of the most common procedures used for skin rejuvenation.AimThe aim of this study was to assess the elasticity of face and chest skin after multipolar radiofrequency.Patients/MethodsThirty women, aged 43‐68, were included in the study. Twenty women were postmenopausal and 10 were premenopausal. They received 4 treatment sessions with an application of nonablative radiofrequency in 2‐week intervals. Biomechanical properties of the skin were measured with the use of a Cutometer.ResultsThe objective evaluation in a cutometric analysis showed a statistically significant improvement between measurements taken in the pretreatment period and 3 months after the treatment.ConclusionsThe study is an objective confirmation that RF treatment improves skin elasticity. The method may appear to be beneficial for women of any age and skin types. It is a noninvasive treatment with a low risk of complications.
Location choice, life cycle and amenities
Authors: Letdin Mariya , Shim Hyoung S. 
Published: April 2019

AbstractOur study proposes a housing location choice model where a household faces a trade‐off between proximity to place of employment and proximity to amenities. We consider subsamples of high amenity cities and low amenity cities and households with and without children. We show that the roles of gender, education, homeownership, household composition, and public transportation vary significantly depending on level of amenities. Households with a female head of household, those with a working spouse and with older children prefer locating closer to downtown amenities. Female workers with and without children locate closer to work, in high and low amenity cities.
Indocyanine green–assisted dental imaging in the first and second near‐infrared windows as compared with X‐ray imaging
Authors: Li Zhongqiang , Zaid Waleed , Hartzler Thomas , Ramos Alexandra , Osborn Michelle L. , Li Yanping , Yao Shaomian , Xu Jian 
Published: April 2019

AbstractIndocyanine green (ICG) has been widely used in medical imaging, such as in retinal angiography. Here, we describe a pilot ex vivo study of ICG‐assisted near‐infrared fluorescence (NIRF) dental imaging in the first (700–950 nm for ICG‐NIRF‐I) and second (1000–1700 nm for ICG‐NIRF‐II) NIR windows using human extracted teeth; our study is compared with the traditional prevalent X‐ray imaging and NIR II illumination (NIRi‐II, 1310 nm) without ICG enhancement. The results show that ICG fluorescence has much better imaging contrast in both windows compared with NIRi‐II (by quantitatively comparing NIR intensity of the critical neighboring structures, such as enamel and dentin). Cracked teeth, notoriously hard to diagnose by dental X‐ray and computed tomography, were clearly profiled in NIRF dental imaging. An insidious occlusal caries, missing in X‐ray imaging, became a bright dot that was readily observed in ICG‐NIRF‐I images. For dental decay, NIRF imaging with ICG enhancement could clearly delineate the decay boundary. NIRF in both windows distinguished interproximal and occlusal superficial caries. Overall, ICG‐assisted NIRF dental imaging has unique advantages in identifying cracked teeth and insidious caries. The two NIR imaging windows used in our study might one day serve as noninvasive and nonionizing‐radiation methods for the diagnosis of critical dental diseases in situ.
Unrelated donor hematopoietic stem cell transplantation for pediatric de novo acute myeloid leukemia with intermediate‐ or high‐risk cytogenetics
Authors: Park Eu Gene , Yi Eun Sang , Choi Young Bae , Sung Ki Woong , Koo Hong Hoe , Yoo Keon Hee 
Published: April 2019

AbstractThe role of unrelated donor HSCT for children with de novo AML in CR1 is controversial. We performed this study to investigate the feasibility of unrelated donor HSCT who initially had intermediate‐ or high‐risk cytogenetics. We retrospectively reviewed medical records of patients with AML who received unrelated HSCT in CR1 at Samsung Medical Center between November 2001 and January 2012. Patients were allocated based on karyotype at diagnosis as follows: (a) low‐risk: inv(16), t(16;16), t(8;21), and t(15;17); (b) high‐risk: ‐5, 5q‐, ‐7, 3q abnormalities, t(8;16), t(6;9), t(6;11), t(6;21), t(10;11), complex karyotype (≥3 abnormalities), and acute megakaryocytic leukemia without t(1;22); and (c) IR: all the other karyotypes including normal. Patients in intermediate‐ or high‐risk group who were transplanted with either unrelated CB or matched unrelated BM/mobilized PB in their CR1 were included in this study. The projected OS and EFS rates were 74.9% and 71.1%, respectively, with a median follow‐up of 87.3 months after transplantation. The EFS was 70.1%, 80.7%, and 73.9% for CB, BM, and mobilized PB groups, respectively (P = 0.89), and 73.9% and 70.6% for IR and high‐risk groups (P = 0.76). The leading cause of death was relapse (n = 8), and only one patient died from non‐relapse cause. Unrelated donor HSCT seems a feasible approach for children with intermediate‐ or high‐risk AML in CR1. Relapse remains the leading cause of treatment failure among these patients.
Strong expression of p53 protein in bone marrow samples after hematopoietic stem cell transplantation indicates risk of relapse in pediatric acute lymphoblastic leukemia patients
Authors: Mattsson Kristin , Honkaniemi Emma , Ramme Kim , Barbany Gisela , Sander Birgitta M. , Gustafsson Britt M. 
Published: April 2019

AbstractBackgroundFor pediatric ALL patients that relapse or respond poorly to conventional chemotherapy treatment, HSCT is one treatment option. Still, relapse occurs in 30% of the children after HSCT. Mutations in the tumor suppressor gene TP53 which can lead to an altered p53 protein expression are rare at time of diagnosis of ALL, yet occur more frequent at relapse indicating a more aggressive disease. Our aim was to evaluate if alterations in the expression of the tumor suppressor protein p53 signaled a relapse in pediatric ALL patients post‐HSCT and could guide for preemptive immunotherapy.ProcedureParaffin‐embedded bone marrow samples from 46 children diagnosed with ALL between 1997 and 2010, and transplanted at Karolinska University Hospital, were analyzed for p53 by IHC. Samples were analyzed independently at diagnosis, before HSCT, and after HSCT 0‐3 months, 3‐6 months, and 6‐12 months.ResultStrong expression of p53 in the bone marrow at 0‐3‐months after HSCT was associated with increased risk of relapse, odds ratio 2.63 (confidence interval 1.08‐6.40) P = 0.033.ConclusionEvaluation of p53 protein expression in bone marrow from pediatric ALL patients that undergo HSCT may be a potential, additional prognostic marker for predicting relapse after HSCT.
Does Partisan Bias Modulate Neural Processing of Political Information? An Analysis of the Neural Correlates of Corruption and Positive Messages
Authors: Casado‐Aranda Luis‐Alberto , Venkatraman Vinod , Sánchez‐Fernández Juan , Luque‐Martínez Teodoro 
Published: April 2019

Daily worldwide newspapers print articles exposing government corruption. Yet these messages do not lead to a loss of votes for the corrupt parties. Sympathizers’ partisan bias, which respectively minimizes and maximizes corruption and positive messages of their own parties respectively, is widely considered the main cause of the loss of effectiveness of political communications. Despite the well‐established existence of such bias when processing political information, little is known as to its psychological origin. Through the use of neuroscience (fMRI), this study explores the underlying brain mechanisms of negative (corruption) and positive political messages related to a conservative and a socialist Spanish political party, as well as the differences between their sympathizers. The findings reveal that negative (vs. positive) political messages exert the greatest neuroimaging impact on the electorate, as shown in aversive, risk, and disappointment‐related brain regions. Interestingly, we show that there exists a main partisan bias against opposite parties (and not a positive bias toward one’s own party) that stems from a higher risk, ambiguity, and disbelief provoked by both positive and negative information about rival parties. Furthermore, this bias was more pronounced among conservative supporters. The current findings provide valuable insights for political parties to improve their communication campaigns.
Endovascular stenting of the superior sagittal sinus to alleviate venous compression caused by a parasagittal meningioma
Authors: Entezami Pouya , Gooch M Reid , Dalfino John 
Published: April 2019

Idiopathic intracranial hypertension (IIH) is a challenging disease with unclear pathophysiology. Recognition of venous sinus stenting to improve intracranial pressure is increasing.We present a 56-year-old man diagnosed with IIH. A parasagittal meningioma abutting the sagittal sinus causing venous compression was found. Venous sinus stenting via endovascular approach using a WALLSTENT was performed. Intravascular pressures recorded after stenting demonstrated resolution of the pressure gradient.The patient had no complications from the procedure and reported substantial symptomatic improvement. Subsequent ophthalmologic exam demonstrated resolution of the bilateral papilledema noted prior to stenting. Endovascular treatment of venous sinus stenosis in the treatment of IIH is an emerging technique. Treatment of venous compromise due to a mass lesion with stenting is a rarely described concept. For our patient, endovascular stenting was the primary treatment modality, allowing the tumour to be followed with serial imaging.
Gonorrhoea and chlamydia in persons with HIV: number needed to screen
Authors: Tuddenham Susan , Ghanem Khalil G , Gebo Kelly A , Moore Richard D , Mathews William Christopher , Agwu Allison , Mayer Kenneth , Schumacher Christina , Raifman Julia , Berry Stephen A 
Published: April 2019

ObjectivesCurrent guidelines recommend screening sexually active persons with HIV (PWH) forNeisseria gonorrhoeae(NG) andChlamydia trachomatis(CT) at least annually. Yet, screening rates in many HIV clinics remain low. In this study, we estimated the number needed to screen (NNS) to detect a NG and/or CT infection at each anatomic site among different subpopulations of PWH. NNS provides a concrete, practical measure to aid in assessing the practical impact of screening.Methods We included adults in care at three HIV Research Network sites in 2011–2014. Restricting to first tests within each year, annual NNS was defined as number of persons tested divided by number positive. We computed urogenital and extragenital NNS by age and risk group (women, men who have sex with women (MSW) and men who have sex with men (MSM)).Results A total of 16 864 NG/CT tests were included. Among patients aged ≤25 years, urogenital NNS was similar among women (15 (95% CI 6 to 71)), MSW (21 (95% CI 6 to 167)) and MSM (20 (95% CI 12 to 36)). Over 25, urogenital NNS increased to a greater extent for women (363 (95% CI 167 to 1000)) and MSW (160 (95% CI 100 to 333)) than MSM (46 (95% CI 38 to 56)). The increase for women versus MSM >25 remained significant (p<0.01) in multivariable analysis. Among MSM, rectal NNS was 5 (95% CI 3 to 7) and 10 (95% CI 9 to 12) for ≤25 and for >25 years and pharyngeal NNS values were 8 (95% CI 5 to 13) and 20 (95% CI 16 to 24).ConclusionsThese findings suggest the importance of regular, at least annual NG/CT screening, particularly extragenital, of HIV positive MSM of all ages. They provide some support for age-based cutoffs for women and MSW (eg, universal screening for those aged ≤25 and targeted screening for those aged >25 years).
Comparison of drift–diffusion model and hydrodynamic carrier transport model for simulation of GaN-based IMPATT diodes
Authors: Li Xiusheng , Yang Lin’an , Ma Xiaohua 
Published: April 2019

This paper presents a numerical simulation of a Wurtzite-GaN-based IMPATT diode operating at the low-end frequency of terahertz range. Conventional classical drift–diffusion model is independent of the energy relaxation effect at high electric field. However, in this paper, a hydrodynamic carrier transport model including a new energy-based impact ionization model is used to investigate the dc and high-frequency characteristics of an IMPATT diode with a traditional drift–diffusion model as comparison. Simulation results show that the maximum rf power density and the dc-to-rf conversion efficiency are larger for conventional drift–diffusion model because it overestimates the impact ionization rate. Through hydrodynamic simulation we revealed that the impact ionization rates are seriously affected by the high and rapidly varied electric field and the electron energy relaxation effect, which lead to the rf output power density and the dc-to-rf conversion efficiency falls gradually, and a wider operation frequency band is obtained compared with the drift–diffusion model simulation at frequencies over 310 GHz.
Numerical Simulations of Fracture Propagation in Jointed Shale Reservoirs under CO2 Fracturing
Authors: Zhang Qi , Ma Dan , Liu Jiangfeng , Wang Jiehao , Li Xibing , Zhou Zilong 
Published: April 2019

Water-based hydraulic fracturing for the exploitation of shale gas reservoirs may be limited by two main factors: (1) water pollution and chemical pollution after the injection process and (2) permeability decrease due to clay mineral swelling upon contact with the injection water. Besides, shale rock nearly always contains fractures and fissures due to geological processes such as deposition and folding. Based on the above, a damage-based coupled model of rock deformation and gas flow is used to simulate the fracturing process in jointed shale wells with CO2 fracturing. We validate our model by comparing the simulation results with theoretical solutions. The research results show that the continuous main fractures are formed along the direction of the maximum principal stress, whilst hydraulic fractures tend to propagate along the preexisting joints due to the lower strength of the joints. The main failure type is tensile damage destruction among these specimens. The preexisting joints can aggravate the damage of the numerical specimens; the seepage areas of the layered jointed sample, vertical jointed sample, and orthogonal jointed sample are increased by 32.5%, 29.16%, and 35.05%, respectively, at time t=39 s compared with the intact sample. The preexisting horizontal joints or vertical joints promote the propagation of hydraulic fractures in the horizontal direction or vertical direction but restrain the expansion of hydraulic fractures in the vertical or horizontal direction.