bluuebunny/crossref_metadata_2025_split huggingface dataset:
Becoming a Teacher of Business English in China: A Critical Narrative
Authors: Ai Bin , Wang Lifei , Kostogriz Alexander 
Published: August 2019

AbstractIn the Chinese higher education sector, Business English, a newly emerging discipline, has attracted great attention, and since it was approved officially in 2007, about 400 universities and colleges have offered this degree course to students. Among in-service Business English teachers, some of them have transferred from teaching English for General Purposes. Business English teachers face many changes and challenges to their professional identity, yet few scholars have looked into the identity construction of these teachers. Using critical narrative as a method, this paper closely examines the identity construction experiences of the first author and two other Business English teachers. It is found that the participants, including the first author himself, have endured identity negotiations and various challenges in turning from a teacher of English for General Purposes to a teacher of Business English. These teachers’ experiences and their perception of identity construction and professional development throw light on the changing pedagogy and practice of Business English in Chinese universities.
„Mind the Gap“ – die ganzheitliche Sicht auf die Lernwelt Hochschule
Authors: Gläser Christine , Gageur Nicole 
Published: August 2019

Zusammenfassung
Im Artikel werden laufende Arbeiten und Ergebnisse des kooperativen Forschungsprojekts Lernwelt Hochschule (LeHo), an dem das Department Information der HAW mitarbeitet, dargestellt. Es wird deutlich, was die Lernwelt Hochschule heute ausmacht und welche Entwicklungen ihr zugrunde liegen. Nach einem kurzen Abriss zur Lernraumentwicklung wird das Projekt LeHo mit dem Forschungsdesign, den Projektphasen und den geplanten Ergebnissen vorgestellt. Die ethnografischen Fallstudien werden als Forschungsschwerpunkt der LeHo-Aktivitäten am Department Information eingeführt.
Characteristic classes of involutions in nonsolvable groups
Authors: Fine Yotam 
Published: August 2019

Abstract
Let

G
,

D
0

,

D
1

{G,D_{0},D_{1}}

be finite groups such that

D
0

⁢
⊴
⁢

D
1

{D_{0}\trianglelefteq D_{1}}

are groups of automorphisms of G that contain the inner automorphisms of G.
Assume that

D
1

/

D
0

{D_{1}/D_{0}}

has a normal 2-complement and that

D
1

{D_{1}}

acts fixed-point-freely on the set of

D
0

{D_{0}}

-conjugacy classes of involutions of G (i.e.,

C

D
1

⁢

(
a
)

⁢

D
0

<

D
1

{C_{D_{1}}(a)D_{0}<D_{1}}

for every involution

a
∈
G

{a\in G}

).
We prove that G is solvable.
We also construct a nonsolvable finite group that possesses no characteristic conjugacy class of nontrivial cyclic subgroups.
This shows that an assumption on the structure of

D
1

/

D
0

{D_{1}/D_{0}}

above must be made in order to guarantee the solvability of G and also yields a negative answer to Problem 3.51 in the Kourovka notebook, posed by A. I. Saksonov in 1969.
A control variate method for weak approximation of SDEs via discretization of numerical error of asymptotic expansion
Authors: Okano Yusuke , Yamada Toshihiro 
Published: August 2019

Abstract
The paper shows a new weak approximation method for stochastic differential equations as a generalization and an extension of Heath–Platen’s scheme for multidimensional diffusion processes. We reformulate the Heath–Platen estimator from the viewpoint of asymptotic expansion. The proposed scheme is implemented by a Monte Carlo method and its variance is much reduced by the asymptotic expansion which works as a kind of control variate. Numerical examples for the local stochastic volatility model are shown to confirm the efficiency of the method.
Invasive Pneumococcal Disease in Children’s Hospitals: 2014–2017
Authors: Kaplan Sheldon L. , Barson William J. , Lin Philana Ling , Romero José R. , Bradley John S. , Tan Tina Q. , Pannaraj Pia S. , Givner Laurence B. , Hulten Kristina G. 
Published: August 2019

BACKGROUND:
The 13-valent pneumococcal conjugate vaccine (PCV13) was licensed in the United States in 2010. We describe invasive pneumococcal disease (IPD) in children at 8 children’s hospitals in the US from 2014 to 2017.

METHODS:
Children with IPD occurring from 2014 to 2017 were identified from a prospective study. Demographic and clinical data, including results of any immune evaluation along with the number and dates of previous pneumococcal conjugate vaccines administered, were recorded on case report forms. Isolate serotypes were determined in a central laboratory. Pneumococcal conjugate vaccine doses were counted if IPD occurred ≥2 weeks after a dose.

RESULTS:
PCV13 serotypes accounted for 23.9% (115 out of 482) of IPD isolates from 2014 to 2017. Serotypes 3, 19A, and 19F accounted for 91% of PCV13 serotypes. The most common non-PCV13 serotypes were 35B, 23B, 33F, and 22F. An underlying condition was significantly (P &lt; .0001) more common in children with IPD due to non-PCV13 serotypes (200 out of 367, 54.5%) than for children with PCV13 serotypes (27 out of 115, 23.5%). An immune evaluation was undertaken in 28 children who received ≥2 PCV13 doses before IPD caused by a PCV13 serotype. Only 1 was found to have an immunodeficiency.

CONCLUSIONS:
PCV13 serotypes (especially serotypes 3, 19A, and 19F) continue to account for nearly a quarter of IPD in US children 4 to 7 years after PCV13 was introduced. Underlying conditions are more common in children with non-PCV13 serotype IPD. Immune evaluations in otherwise healthy children with PCV13 serotype IPD despite receiving ≥2 PCV13 doses did not identify an immunodeficiency.
Demographic and psychiatric correlates of compulsive sexual behaviors in gambling disorder
Authors: Cowie Megan E. , Kim Hyoun S. , Hodgins David C. , McGrath Daniel S. , Scanavino Marco D. T. , Tavares Hermano 
Published: August 2019

Background and aims
Gambling disorder (GD) and compulsive sexual behavior (CSB) may commonly co-occur. Yet, the psychiatric correlates of these co-occurring disorders are an untapped area of empirical scrutiny, limiting our understanding of appropriate treatment modalities for this dual-diagnosed population. This study examined the demographic and clinical correlates of CSB in a sample of treatment-seeking individuals with GD (N = 368) in São Paulo, Brazil.

Methods
Psychiatrists and psychologists conducted semi-structured clinical interviews to identify rates of CSB and other comorbid psychiatric disorders. The Shorter PROMIS Questionnaire was administered to assess additional addictive behaviors. The TCI and BIS-11 were used to assess facets of personality. Demographic and gambling variables were also assessed.

Results
Of the total sample, 24 (6.5%) met diagnostic criteria for comorbid CSB (GD + CSB). Compared to those without compulsive sexual behaviors (GD − CSB), individuals with GD + CSB were more likely to be younger and male. No differences in gambling involvement emerged. Individuals with GD + CSB tended to have higher rates of psychiatric disorders (depression, post-traumatic stress disorder, and bulimia nervosa) and engage in more addictive behaviors (problematic alcohol use, drug use, and exercise) compared to GD − CSB. Those with GD + CSB evidenced less self-directedness, cooperativeness, self-transcendence, and greater motor impulsivity. Logistic regression showed that the predictors of GD + CSB, which remained in the final model, were being male, a diagnosis of bulimia, greater gambling severity, and less self-transcendence.

Discussion and conclusion
Given those with GD + CSB evidence greater psychopathology, greater attention should be allocated to this often under studied comorbid condition to ensure adequate treatment opportunities.
O socialismo religioso de Paul Tillich
Authors: Silva Edson Pereira 
Published: August 2019

Nosso objetivo é discorrer sobre o socialismo religioso de Paul Tillich. Para tanto, propomos em primeiro lugar, apresentar algumas fases concretas na vida de Paul Tillich que engendraram em sua decisão, pela qual ele vai concentrar seu pensamento em direção a uma filosofia da história para a construção do seu pensamento político. Em segundo lugar, apontar a interpretação da história como método para compreensão da história política. Por fim, discorrer sobre as principais ideias que caracterizam o socialismo religioso.
A Randomized, Double-Blinded, Phase II Trial of Carboplatin and Pemetrexed with or without Apatorsen (OGX-427) in Patients with Previously Untreated Stage IV Non-Squamous-Non-Small-Cell Lung Cancer: The SPRUCE Trial
Authors: Spigel David R. , Shipley Dianna L. , Waterhouse David M. , Jones Suzanne F. , Ward Patrick J. , Shih Kent C. , Hemphill Brian , McCleod Michael , Whorf Robert C. , Page Ray D. , Stilwill Joseph , Mekhail Tarek , Jacobs Cindy , Burris Howard A. , Hainsworth John D. 
Published: August 2019

Abstract

Background
This randomized, double-blinded, phase II trial evaluated the efficacy of carboplatin and pemetrexed plus either apatorsen, an antisense oligonucleotide targeting heat shock protein (Hsp) 27 mRNA, or placebo in patients with previously untreated metastatic nonsquamous non-small cell lung cancer (NSCLC).

Methods
Patients were randomized 1:1 to Arm A (carboplatin/pemetrexed plus apatorsen) or Arm B (carboplatin/pemetrexed plus placebo). Treatment was administered in 21-day cycles, with restaging every two cycles, until progression or intolerable toxicity. Serum Hsp27 levels were analyzed at baseline and during treatment. The primary endpoint was progression-free survival (PFS); secondary endpoints included overall survival (OS), objective response rate, and toxicity.

Results
The trial enrolled 155 patients (median age 66 years; 44% Eastern Cooperative Oncology Group performance status 0). Toxicities were similar in the 2 treatment arms; cytopenias, nausea, vomiting, and fatigue were the most frequent treatment-related adverse events. Median PFS and OS were 6.0 and 10.8 months, respectively, for Arm A, and 4.9 and 11.8 months for Arm B (differences not statistically significant). Overall response rates were 27% for Arm A and 32% for Arm B. Sixteen patients (12%) had high serum levels of Hsp27 at baseline. In this small group, patients who received apatorsen had median PFS of 10.8 months, and those who received placebo had median PFS 4.8 months.

Conclusion
The addition of apatorsen to carboplatin and pemetrexed was well tolerated but did not improve outcomes in patients with metastatic nonsquamous NSCLC cancer in the first-line setting.

Implications for Practice
This randomized, double-blinded, phase II trial evaluated the efficacy of carboplatin and pemetrexed plus either apatorsen, an antisense oligonucleotide targeting heat shock protein 27 mRNA, or placebo in patients with previously untreated metastatic nonsquamous non-small cell lung cancer (NSCLC). The addition of apatorsen to carboplatin and pemetrexed was well tolerated but did not improve outcomes in patients with metastatic nonsquamous NSCLC cancer in the first-line setting.
La elaboración de proyectos de inversión como estudio de casos de estudio para lograr aprendizajes significativos
Authors: Arciniegas Calderón Ana Isabel 
Published: August 2019

Se presenta una propuesta para lograr aprendizajes significativos mediante el estudio de casos de formulación de proyectos de inversión. Se expone el análisis, crítico e integral, del estudio de un caso práctico: la conveniencia de mejorar o diversificar el portafolio de productos de una empresa ya existente. Se explican los principales términos y conceptos. Se describe el proceso metodológico usado y se detalla la secuencia de actividades del proceso para elaborar el proyecto de inversión tomado como caso de estudio. Se presentan resultados obtenidos al final del trabajo tanto dentro como fuera del aula. Por último, se concluye que los estudiantes sí logran aprendizajes significativos mediante el estudio de casos.
Investigación, práctica curricular y virtualidad: experiencias en Venezuela
Authors: Schmidt H. Ludwig 
Published: August 2019

Con respecto a la triada investigación, práctica curricular y virtualidad, la educación virtual ha evidenciado un emprendimiento más efectivo, al superar escollos de tiempo y espacio mediante innovadores métodos, técnicas y recursos que hacen más efectivo y flexible el proceso de enseñanza-aprendizaje. Esta nueva modalidad educativa da validez así a los principios de educación para todos, aprender a aprender, la enseñanza-aprendizaje personalizada, la educación para toda la vida, es decir, la educación permanente o continua. Además, permite una relación particular con el desarrollo de un pensamiento crítico latinoamericano, cuya preocupación por el conocimiento de los límites de la sociedad actual y las posibilidades de configurar un orden más humano y justo enriquece lo social y la convivencia armónica.
Kripto Para Birimlerinin Piyasa Değerlerindeki Değişimlerin Analizi
Authors: Gültekin Yaşar , Özdemir Fevzi Serkan , Varıcı İdris 
Published: August 2019

Kripto para birimleri; paranın piyasaya
sürülmesi ve kullanıcıları arasındaki transfer işlemlerinde kriptografiyi
kullanan elektronik para birimleridir. 2009 yılında ilk kez Satoshi Nakamoto
tarafından teknik altyapısı kurularak piyasadaki yerini alan Bitcoin’in
ardından şifreleme algoritmaları, işlem kanıtları ve madencilik faaliyetine
konu olmaları bakımından farklı özelliklere sahip yüzlerce kripto para birimi
ortaya çıkmıştır. Bu para birimleri, tarihsel süreçte bir yatırım aracı olarak
da kullanılmaya başlanmıştır. Günümüzde, bu para birimleri ile işlem yapan
piyasalar oluşmuş ve 2017 yılı başı itibariyle toplamda yaklaşık 17,7 milyar
dolarlık piyasa değerine ulaşılmıştır. 2016 yılı başına kadar bu piyasa
değerinin %90’lık kısmından fazlasına sahip olan Bitcoin’in piyasa payı gün
geçtikçe azalmış ve bu da piyasayı oluşturan diğer para birimlerinin
incelenmesini gerekli hale getirmiştir. Bu
çalışma 01.01.2017 tarihinde piyasada bulunan ve piyasa değeri en yüksek on
kripto para biriminin günlük fiyat değişimleri ile piyasa değeri bakımından ilk
yüzü oluşturan kripto para birimlerinin fiyat değişimleri arasında korelasyon
olup olmadığını belirlemek amacıyla yapılmıştır. Çalışma sonucunda, piyasada
bulunan kripto para birimlerinin değer değişimi açısından toplu mu yoksa ayrık
mı hareket ettiği tespit edilecek ve yorumlanacaktır. Çalışmaya konu olan para
birimlerinin fazlalığı nedeniyle veriler 2016 takvim yılı için toplanmış ve
analiz edilmiştir. Anahtar Kelimeler: Kripto Para, Yatırım,
Analiz.

JEL Sınıflandırması: G11.
Systematic review on HIV situation, gaps and challenges in Addis Ababa, Ethiopia
Authors: Adal Melaku 
Published: August 2019

Abstract
Background

HIV prevalence in the Addis Ababa is still higher in key and priority populations. Therefore, this systematic review was carried out aiming in determining the prevalence of HIV, mortality rate by HIV/AIDS and predisposing risk factors, identification of hotspot areas, key and priority populations, availability and utilization of services, and challenges and gaps to be addressed for prevention and control of HIV epidemic in Addis Ababa.Methods

The documents relevant to address the objectives were collected from online databases Google scholar and PubMed for published works. In addition, unpublished survey and surveillance reports, performance reports and project assessment findings, and mapping results were collected from partner organizations working on HIV/AIDS prevention and control.Results

It appears that the HIV prevalence stabilizes, but varies along areas and socio-demographic groups. The most common hot spots in Addis Ababa are areas where bars, groceries, pensions, guest houses, hotels, brothels, massage houses, khat houses, shisha houses, night clubs, drinking establishments and tourist frequented settings are concentrated. The recognized key population (KP) is the female sex workers (FSWs). There is sexual mixing of key and priority populations (KPPs) with the general population. There are various behavioural, biological and socio-economic predisposing risk factors that drive HIV epidemic, and respective behavioural, biomedical and structural intervention measures are identified in the presence of gaps and challenges to address the problem.Conclusions

HIV prevalence in Addis Ababa seems stabilized. However, it varies along different groups of the population. There are many behavioural, biological and socio-economic factors that predisposed to HIV/AIDS. Weak monitoring of the quality of interventions, limited linkage of positive clients, lost to follow up, financial shortage, limited man power and coordination, data quality and gaps in use of program data or research findings are some of the gaps and challenges. Therefore, prevention and control measures using behavioural, structural and biomedical interventions through filling of gaps and tackle challenges should be strengthened in order to prevent and control HIV/AIDS.
“Dying due to poverty and lack of easy transport”: A qualitative study on access and availability of pre-hospital emergency medical services in Kampala, Uganda
Authors: Mehmood Amber , Wadhwaniya Shirin , Zziwa Esther Bayiga , Kobusingye Olive C 
Published: August 2019

Abstract
Background

Emergency care services in low-and middle-income countries (LMICs) have traditionally received less attention in the dominant culture favouring vertical health programs. The unmet needs of pre-hospital and hospital-based emergency services are high but the barriers to accessing safe and quality emergency medical services (EMS) remain largely unaddressed. Few studies in Sub-Saharan Africa have qualitatively investigated barriers to EMS use, and quality of pre-hospital services from the providers and community perspective. We conducted a qualitative study to describe the patient-centred approach to emergency care in Kampala, Uganda, with specific attention to access to EMS.Methods

The data collection was comprised of Key Informant Interviews (KII) and Focus Group Discussions (FGDs) with the community members. KII participants were selected using maximum purposive sampling based on expert knowledge of emergency care systems, and service delivery. FGDs were conducted to understand perceptions and experiences towards access to pre-hospital care, and to explore barriers to utilization of EMS. The respondents of ten KII and seven FGDs included pre-hospital EMS (PEMS) administrators, policy makers, police, health workers and community members. We conducted a directed content analysis to identify key themes and triangulate findings across different informant groups.Results

Key themes emerged across interviews and discussions concerning: (1) lack of funds, (2) lack of standards, (3) need for upfront payments for emergency transport and care, 4) corruption, 5) poor quality pre-hospital emergency service, 6) poor quality hospital emergency care, and 7) delay in seeking treatment.Conclusions

Patient-centred emergency care should be an integral part of comprehensive health care services. As Uganda and other LMICs continue to strive for universal health coverage, it is critical to prioritize and integrate emergency care within health systems owing to its cross-cutting nature. Community perceptions around access and quality of PEMS should be addressed in national policies covering affordable and safe EMS.
A Comparison of Lumbosacral Kinematics during Prolonged Sitting in Non-specific Chronic Low Back Pain Subgroups; a cross-sectional study
Authors: Alameri Mansoor , III Everett Lohman , Daher Noha , Dudley Robert , Shallan Amjad , Jaber Hatem 
Published: August 2019

Abstract
Abstract
Background: Although, non-specific chronic low back pain (NSCLBP) has been associated with abnormal lumbosacral kinematics, little is known about the possible driving mechanisms of pain development overtime during prolonged sitting period. Therefore, the purpose of this study was to examine the differences in lumbosacral postures in adults with and without NSCLBP, and their role on pain development during a 1-hour of prolonged sitting task.
Methods: Twenty NSCLBP subjects with motor control impairment (MCI) [10 classified as having flexion pattern (FP) disorder, and 10 with active extension pattern (AEP) disorder], and 10 healthy controls participated in the study. Subjects underwent a 1-hour sitting protocol on a standard office chair. Lumbosacral postures including: sacral tilt (ST), third lumbar vertebrae (L3) position, and relative lower lumbar angle (RLLA) were recorded using a two-dimensional inclinometer over the 1-hour period. Perceived back pain intensity was recorded using a numeric pain rating scale every 10 minutes throughout the sitting period.
Results: All study groups presented with significantly distinctive lumbosacral kinematics at the lowest level of pain (the beginning of the sitting period) (p<0.05), as well as at the highest level of pain (the end of the sitting period) (p£0.05). The MCI subgroups showed a significant deterioration in lumbosacral kinematics and pain levels overtime (p<0.01). The directions of deterioration in lumbosacral kinematics over the 1-hour sitting period occurred in the direction of the motor control impairment (kyphosis for FP subgroup or lordosis for the AEP subgroup). Both MCI subgroups reported a similarly significant increase in pain through mid-sitting (p<0.001). However, after mid-sitting, the AEP subgroup displayed a significantly reversed decrease in the lordotic postures (p=0.001) which was accompanied by much less increase in pain level compared to the FP subgroup.
Conclusion : The present study’s findings suggest that MCI subgroups presented with distinctive underlying maladaptive postural patterns. However, the significant increase in pain over the 1-hour sitting might not be only attributed to the inherent maladaptive postures, also it may be related to the directional deterioration in lumbosacral postures overtime.
Probing into Therapeutic Anti-cancer Potential of Apigenin: Recent Trends and Future Directions
Authors: Sharma Ajay , Ghani Abdul , Sak Katrin , Tuli Hardeep S. , Sharma Anil K. , Setzer William N. , Sharma Sanjeev , Das Amit K. 
Published: August 2019

Background:
Natural products represent a therapeutic option for the treatment of inflammation-
associated diseases. Flavonoids which are one of the special categories of such natural products,
have previously shown promising therapeutic potential.

Objectives:
The current review discusses the synthetic preview and anti-inflammatory potential of apigenin
along with the underlying molecular mechanism in chronic human diseases especially cancer. In
addition, the relevant patents on the therapeutic potential of apigenin have also been mentioned.

Methods:
A literature search was carried out using PubMed/Science, Google Scholar, etc. which was
further expended by the different combination of keywords: apigenin, inflammation, mechanism, therapeutic
potential, cancer, etc. Patent information was retrieved by searching the key terms: apigenin,
inflammation, therapeutic potential from various databanks including Espacenet, Google Patents, Free
Patents Online and Mendeley of WIPO, USPTO, SIPO, JPO, KIPO and EPO databases.

Results:
A total of 76 references have been found relevant with the theme of the manuscript. These
citations have described recent ongoing advances in the area of inflammation and cancer with respect to
apigenin.

Conclusion:
Studies related to the anti-inflammatory and anticancer potential of apigenin have been
explored through this review article. Moreover, the patent analysis of apigenin has further strengthened
its therapeutic role. Probing into the therapeutic properties of apigenin, further adds value to this molecule
in terms of its downregulation of major inflammatory and cancer-associated signaling pathways.
The article would simultaneously assist the scientific community to precisely understand the role of
apigenin and design novel anti-cancer therapies.