bluuebunny/crossref_metadata_2025_split huggingface dataset:
Creutzfeldt-Jakob Disease Presenting with Dementia and Mimic a Stroke During One Year: Case Report and Review of Literatures
Authors: Vakilian Alireza , Fekri Mohaddaseh , Farahmand Habib 
Published: January 2019

Background: Creutzfeldt-Jakob disease (CJD) is a progressive and fatal prion disease in human and its annual incidence is estimated one per million. Sporadic form of CJD is the most common form of the disease that involved 85% of cases. Case Report: We presented two cases of CJD with the different clinical presentation; a 58-year-old woman who referred with amnesia, depression and a 59-year-old woman with ataxia as her chief complaint. Based on the findings and rolled-out the other differential diagnosis, the CJD was confirmed. Both of them died before 12 months after diagnosis. Conclusion: Although CJD is a rare disease with different clinical manifestation, it is considered as one the differential diagnosis of progressive dementia.[GMJ.2019;inpress;e1357]
CHANGES IN THE CELLULAR IMMUNE PROTECTION OF ORGANISM IN THE PROCESS OF CHRONIZATION OF EXPERIMENTAL BACTERIAL-IMMUNE PERIODONTITIS
Authors: Demkovych A.Ye. , Bondarenko Yu.I. , Yakymchuk M.M. 
Published: January 2019

One of the important factors that leads to damage of structures of the periodontal complex and leads to the formation of inflammatory process of varying degrees is the disruption of immunological processes.
The aim of the study was to clarify the pathogenetic role of cellular adaptive immunity in the process of formation of chronic inflammatory reaction in the late period of the experimental bacterial-immune periodontitis. The study was conducted on white, non-breeding, clinically healthy male rats. Experimental bacterial-immune periodontitis in experimental animals was caused by insertion into the tissues of the periodontal complex a mixture of microorganisms diluted with egg protein. The obtained digital data was statistically processed using parametric and nonparametric statistical methods.
The article represents the results of research on the parameters of cellular immune defense, determined by the relative number of CD3+ (common T-lymphocytes), CD4+ (T-helpers), CD8+ (cytotoxic cells, T-killers), CD19+ (B-lymphocytes), CD16+ (natural killers, NK-cell) and immunoregulatory index (CD4+ / CD8+) in intact animals and on the 30th day of experimental bacterial-immune periodontitis development. It was established that the nature of the course of experimental inflammation in the tissues of the periodontal complex depended on changes in the cellular immune status, accompanied by a decrease of the content of common mature T-lymphocytes (CD3+) in the blood of animals with experimental bacterial-immune periodontitis on the 30th day of the study. In the process of the development of the experimental bacterial-immune periodontitis there was a decrease of the content of T-lymphocytes-helper (CD4+) in the blood of animals and on the 30th day of the study an increase in T-suppressors (CD8+), an increase in the content of natural killers (CD16+) and a decrease in the relative content of B-lymphocytes (CD19+). The immunoregulatory index (CD4+ / СD8+) decreased in comparison with this indicator of a group of intact animals. In rats with bacterial-immune periodontitis, an immunosuppressive state developed in the late period of the inflammatory reaction due to both T-helper cells and cytotoxic T-suppressors / killers. These changes can be considered as signs of formation of the chronic course of the inflammatory process in the tissues of periodontal complex.
LEVEL OF ORAL HYGIENE IN CHILDREN DURING THE FIRST PERIOD OF MIXED DENTITION
Authors: Kaskova L.F. , Mandziuk T.B. , Novikova S.Ch. , Ulasevych L.P. 
Published: January 2019

During the first period of mixed dentition, when secondary dentition processes begin, children have a certain feeling of discomfort in their oral cavity, as well as pain during personal oral care procedures. This, in turn, causes gentler cleaning that contributes to dental deposits and development of caries.
Studies of oral cavity condition in children during the first period of mixed dentition have shown that level of hygiene in children with caries is always worse than in children without caries irrespectively of their age or sex. A better mouth hygiene index is observed in children aged between 7 and 9, which is explained by the improvement of manual skills in older children. Girls brush their teeth more properly, which is confirmed by a higher level of their oral hygiene compared to boys.
ESTIMATION OF INFLUENCE OF THE THERAPEUTIC – PROPHYLACTIC COMPLEX ON THE IMMUNE SYSTEM INDICES OF EXPERIMENTAL ANIMALS WITH SIMULATED GINGIVITIS
Authors: Malko N.V. , Bezvushko E.V. 
Published: January 2019

In order to assess the influence of heavy metals, iodine and fluoride deficiency on the status of periodontal tissues in rats experimental studies were carried out on 100 white rats, which were divided into 5 groups of 20 animals in each. 1-st group included intact rats; 2-nd - rats with gingivitis; 3-rd - rats with gingivitis exposed to heavy metals by means of adding cadmium and lead to drinking water; 4-th - animals with gingivitis exposed to heavy metals, as well as iodine and fluoride deficiency; 5-th - animals with gingivitis exposed to heavy metals, under iodine and fluoride deficiency, receiving therapeutic-prophylactic complex. Immunological status of animals was evaluated by means of measuring the level of immunoglobulins in serum. Immunoglobulins (Ig) G, A, and M were determined by their radial immunodiffusion in agar according to G. Manchini et al. using diagnostic kits of the firm "Microgene". The count of leukocytes in the peripheral blood of animals was determined by means of the Goryaev’s chamber.
It was found that under influence of heavy metals in combination with iodine and fluoride deficiency the levels of immunoglobulins A and M in blood serum of rats were decreased by 2.5 times, and Ig G ‒ by 2.6 times. The application of the therapeutic-prophylactic complex in 5-th group of rats significantly corrected immunological status of their blood, which was characterized by a significant increase in levels of immunoglobulins.
FEATURES OF PHYSICAL DEVELOPMENT AND TOOTH DECAY MORBIDITY IN CHILDREN WHO LIVE IN ENVIRONMENTALLY ADVERSE CONDITIONS
Authors: Lagoda L.S. , Musji-Sementsiv H.G. , Lisak T.Y 
Published: January 2019

Introduction. Physical development of children is one of the important indicators of the health of the children's population. The state of physical development of the child to a certain extent is reflected in the vital activity of the child's body and is the basis for preventing the emergence of a number of pathological disorders.
The aim. Assessment of physical development and tooth decay in children living in environmentally unfavorable conditions.
Material and methods. 410 schoolchildren of 12 years old living on the territory of the Volyn region with different ecological problems were examined for the evaluation of dental health (HR) and physical development (FR). Anthropometric methods of investigation were used to assess physical development. The length of the body (in cm) and body weight (in kg) were determined. The analysis of the obtained results was carried out using nonparametric methods using the centenary tables [10]. The dental health level (HRD) was determined by the method of PA. Lewis [11]. The prevalence of dental caries was estimated as a percentage, caries intensity according to KPV indices in conventional units according to WHO criteria.
Results and discussion. A detailed analysis of the results showed that the data of physical development (DF) and dental health (SDS) (Table 1) were somewhat related to the place of residence of children and the environmental situation around. It has been found that SRH in children is lower in radioactive contaminated areas, namely in the settlements of Lyubeshiv and Manevich, and ranges from 53.10 ± 1.75% to -58.92 ± 1.62%. In technogenically polluted Novovolynsk, these figures are slightly higher (66.50 ± 1.39%) compared to radioactive contaminated areas. The highest level of SRH among all surveyed children was detected in Lutsk 76.24 ± 2.10%.
Conlusions. The dental health of children living in different ecological conditions is closely related to their physical development. It has been established that boys and girls living in conditionally clean areas are more likely to register average and above average growth rates.
INTRODUCTION OF INNOVATION TECHNIQUES IN THE HIGH SCHOOL
Authors: Boichenko O.M. , Sidash Yu.V. 
Published: January 2019

At present, one of the main features of modern society is its development on the basis of innovations, therefore the purpose of this publication is an attempt to characterize the means, forms and various methods of innovative students’ teaching in higher medical institutions of Ukraine, to reveal the specifics of their use in an interactive environment.
Modern methods of teaching profiled disciplines among graduates of higher educational institutions are a constant source of observation of foreign and Ukrainian scholars, as many students from near and far abroad are currently receiving education in Ukraine. To ensure the fulfillment of this task there are such documents as a State National Program "Education (Ukraine XXI Century)", the National Doctrine of Education Development (2002), the Law of Ukraine "On Higher Education" adopted in 2014, and the draft Concept for the Development of Education Ukraine for the period 2015-2025 and the draft Strategy for the reform of higher education in Ukraine until 2020 [1]. These documents provide a significant reform of the educational process in order to form a creative professional with a deep knowledge of teaching discipline, strong skills and abilities through the "training of applicants for higher education with modern scientific knowledge using the latest educational and information technologies." Thus, the introduction of modern innovative technologies into the educational process of universities is necessary, first of all, this is connected with the necessity of improving the teaching process, the degradation of the existing traditional educational process, and radical transformations and complex modifications. In time, pedagogy applies a large number of different innovative teaching methods that direct students to the qualitative learning of knowledge, and the development of their intellectual activities, the formation of skills and critical thinking skills, the ability to independently process information, acquire qualities that will be useful in future professional life.
KEKUATAN HUKUM AKTA PERJANJIAN TANPA BEA MATERAI
Authors: Santoso Lukman 
Published: January 2019

Legal Commitments in essence is the governing law of interest between individuals. Subject engagement in the modern era, there are all kinds nomenclature attached to a deed of contract. This paper aims to peel around Strength Without Legal Deed Stamp Duty. Functions seal as defined in the law No. 13 is a tax on documents used by the people in the traffic law to prove a situation, the fact and deed that is civil. Submitted written evidence in civil procedure should be affixed with a seal to be used as evidence in court. But this does not mean the absence of the stamp in written evidence causing it unlawful legal act performed, only the deed of legal actions that do not qualify to be used as evidence in court. As for determining the validity of the deed of contract is pursuant to Article 1320 of the Civil Code.
Hukum Perikatan pada hakikatnya merupakan hukum yang mengatur tentang kepentingan antara perseorangan. Perihal perikatan di era modern, muncul beragam nomenklatur yang melekat dalam sebuah akta perjanjian. Tulisan ini bertujuan mengupas seputar Kekuatan Hukum Akta Perjanjian Tanpa Bea Materai. Fungsi meterai yang sebagaimana ditegaskan dalam undang-undang No 13 Tahun adalah sebagai pajak atas dokumen yang digunakan masyarakat dalam lalu lintas hukum untuk membuktikan suatu keadaan, kenyataan dan perbuatan yang bersifat perdata. Alat bukti tertulis yang diajukan dalam acara perdata harus dibubuhi meterai agar dapat digunakan sebagai alat bukti pengadilan. Namun hal ini bukan berarti dengan tiadanya materai dalam alat bukti tertulis menyebabkan tidak sahnya perbuatan hukum yang dilakukan, hanya saja akta dari perbuatan hukum yang dilakukan itu tidak memenuhi syarat untuk dapat digunakan sebagai alat bukti pengadilan. Adapun yang menentukan sahnya akta perjanjian adalah sesuai ketentuan Pasal 1320 KUH Perdata.
IMPROVING LISTENING AND SPEAKING ACHIEVEMENTS OF THE EIGHTH GRADE STUDENTS OF SMP NEGERI 6 METRO BY USING VIDEOS PLUS DISCUSSION METHOD
Authors: Amalia Rizka 
Published: January 2019

Listening and speaking are the important skills that have to be mastered by the students. By having these skills, the students can communicate with others easily. However, the teaching and learning of listening and speaking skills are still problematical. The objectives of this study were to find out whether or not videos plus discussion method was effective in improving the students’ listening and speaking achievements. This study involved one hundred and ninety six of the eighth grade students of SMP Negeri 6 Metro and forty of them were selected as the sample by using purposive sampling technique. The results of this study showed that the videos plus discussion method was considered as one of the effective ways to improve the students’ listening and speaking achievements.
ОСОБЛИВОСТІ ПАТОГЕНЕЗУ ХВОРОБ ОГІРКА В УМОВАХ ПЛІВКОВИХ ТЕПЛИЦЬ ЗА ВЕСНЯНО-ЛІТНЬОЇ КУЛЬТУРОЗМІНИ
Authors: Onyshcenko O. I. , Chaiuk O. O. 
Published: January 2019

Мета. Уточнити видовий склад та особливості патогенезу основних хвороб огірка в теплицях із плівковим укриттям за беззмінного використання тепличних ґрунтів у весняно-літній культурозміні. Методи. Фітосанітарний стан посівів огірка оцінювали впродовж усього вегетаційного періоду рослин (квітень – початок серпня). При цьому визначали поширеність та інтенсивність розвитку хвороб. Ідентифікацію збудників хвороб грибної етіології проводили використовуючи методи вологої камери та чистих культур із послідуючим мікроскопіюванням; хвороби бактеріальної та вірусної етіології визначали за візуальним аналізом симптомів. Результати. Встановлено, що рослини огірка в умовах плівкових теплиць із беззмінним використанням ґрунтів значною мірою уражуються грибними, бактеріальними та вірусними хворобами. Зафіксовано ураження рослин огірка у фазах онтогенезу: 3–4 справжніх листки, початок цвітіння, масове плодоношення. Фітопатологічний аналіз уражених рослин засвідчив, що на ранніх етапах онтогенезу рослин огірка домінуючу роль у патогенезі хвороб займають збудники кореневих гнилей – гриби з роду Fusarium. У фазу початку цвітіння, щорічно відмічається ураження рослин бактеріальними і вірусними хворобами, проте аналіз динаміки їх розвитку засвідчив, що в умовах плівкових теплиць вони не мають економічного значення. У фазу масового плодоношення найбільш економічно значущою є несправжня борошниста роса, інтенсивність розвитку якої становила 82–88 %, що свідчить про епіфітотійний характер розвитку хвороби в умовах плівкових теплиць. Висновки. Моніторинг видового складу збудників хвороб засвідчив, що рослини огірка в умовах плівкових теплиць лівобережного Лісостепу України уражують хвороби: грибної етіології (кореневі гнилі, фузаріозне в’янення, біла гниль, несправжня борошниста роса, борошниста роса) бактеріальної (кутаста бактеріальна плямистість) та вірусної етіології. Визначені особливості патогенезу цих хвороб за роками залежно від фаз онтогенезу. Установлено специфічні симптоми їх прояву. Домінуючу частку в патокомплексі огірка в умовах плівкових теплиць становлять хвороби грибної етіології
Reflexões e propostas para melhoria das perícias médicas na Justiça do Trabalho
Authors: Simão de Melo Raimundo 
Published: January 2019

O artigo tem como objetivo propor sugestões de melhoria para as perícias técnicas realizadas no âmbito da Justiça do Trabalho, considerando-se que a atividade é essencial para a preservação e promoção do meio ambiente de trabalho sadio e seguro e também para a obtenção de provimentos jurisdicionais justos em casos que envolvam a temática dos acidentes de trabalho. Por meio de análise crítica, é observado que a nomeação particular de peritos constitui risco de comprometimento da imparcialidade dos experts, indicando-se alternativas para o recrutamento de peritos técnicos. Além disso, ainda são elencadas diretrizes para o próprio desempenho da atividade pericial, versando-se, ainda, sobre as possibilidades de atuação do Juízo em face dos laudos elaborados, uma vez que o Magistrado poderá optar por designar novas perícias e até mesmo demandar a oitiva dos especialistas para a formação do seu convencimento. Observados estes dados, e também por meio da análise de jurisprudência, chega-se à conclusão de que tais medidas teriam o condão de dificultar o tráfico de influências nas atividades periciais, aumentando a qualidade técnica dos pareceres e dando maior credibilidade a esta importante função jurisdicional, que também restou prejudicada por alterações trazidas pela Reforma Trabalhista (Lei 13.467/2017).PALAVRAS-CHAVE: Acidente. Trabalho. Perícia médica. Justiça do Trabalho.
Abstract
The purpose of this article is to offer suggestions about improvement of the technical expertise carried out within the Labor Justice, considering that the activity is essential to the preservation and promotion of a healthy and safe working environment and for obtaining fair legal decisions in cases involving the issue of occupational accidents. Through a critical analysis, it is observed that the appointment of private experts constitutes a risk that compromises their own impartiality, being indicated alternatives for the recruitment of technical experts. In addition, guidelines for the expert’s activity are listed, as well as the Judges’ possibilities of action towards the technical reports made by the experts, since the Magistrate may choose to appoint new experts and even hear the experts to form their convincement. Based on these data and on the analysis of legal decisions, it is concluded that such measures would make it difficult for cases of corruption in expert activities to happen, increasing the technical quality of expert opinions and giving greater credibility to this important jurisdictional function, which has also been compromised by changes brought about by the Labor Reform (Law 13467/2017).KEYWORDS: Work accident. Labour. Medical expertise. Labour Justice.
Licenziamento, diritto del lavoro e ideologia
Authors: Loy Gianni 
Published: January 2019

Em distintas fases históricas, pelo menos três, o Direito do Trabalho foi interrogado sobre a disciplina a ser aplicada à demissão ou ao recesso. Uma breve leitura dessas três fases consente de colocar em evidência as relações intercorrentes entre a norma e a elaboração doutrinária e jurisprudencial, isto é as “construções jurídicas” que acompanharam a sua evolução. Tomarei em consideração as fase das origens, a fase pós-constitucional e obviamente a fase atual. Eu o farei procurando colher o nexo com as ideologias do tempo para alcançar a conclusão que, fundamentalmente, o problema de fundo, que é o de escolher o modelo preferido, é sempre o mesmo e é focalizado no reconhecimento da assimetria das partes na relação de trabalho, e em particular no momento da demissão. Poder-se-á observar como o Direito do Trabalho, nesta matéria, resulta densamente tributário do predomínio de ideologias externas a ele.
PALAVRAS-CHAVE: Direito do Trabalho. Relação de Trabalho. Demissão. Assimetria. Ideologia.
Riassunto
In distinte fasi storiche, almeno tre, il Diritto del lavoro si è interrogato sulla disciplina da applicare al licenziamento, o al recesso. Una breve rilettura di queste tre fasi consente di mettere in evidenza le relazioni intercorrenti tra la norma e l’elaborazione dottrinale e giurisprudenziale, cioè le “costruzioni giuridiche” che hanno accompagnato la sua evoluzione. Prenderò in considerazione la fase delle origini, quella post-costituzionale e ovviamente la fase attuale. Lo farò cercando di cogliere il nesso con le ideologie del tempo per arrivare alla conclusione che, in definitiva, il problema di fondo, che è quello scegliere il modello preferibile, è sempre lo stesso ed è incentrato sul riconoscimento della asimmetria della parti nel rapporto di lavoro, ed in particolare nel momento del recesso. Si potrà osservare come il Diritto del lavoro, in questa materia, risulti fortemente tributario dal predominio di ideologie esterne ad esso.
PAROLE CHIAVE: Diritto del Lavoro. Rapporto di Lavoro. Licenziamento. Asimmetria. Ideologia.
Abstract

In distinct historical phases, at least in three of them, Labor Law has been questioned about which discipline to apply to the dismissal or to the withdrawal. A brief reading of these three phases intends to evidence the intercurrent relations between the norm and doctrinal and jurisprudential elaborations, that is, the “legal constructions” that have accompanied their evolution. I will take into consideration the origins phase, the post-constitutional phase and obviously the current phase. I will seek to grasp the link between the ideologies of the time in order to reach the conclusion that fundamentally the key issue, which is the choice for the preferred model, is always the same and focuses itself on the recognition of asymmetry between the parties in a labor relation, particularly in the moment of withdrawal. It will be possible to observe how Labor Law, in this matter, is strongly tributary to the predominance of ideologies external to it.
KEYWORDS: Labor law. Work Relations. Dismissal. Asymmetry. Ideology.
Vitamin D and bone mineral density status among postmenopausal Bangladeshi women
Authors: Ahmed AKM Shaheen , Haque Wasim Md Mohosin Ul , Uddin Khwaja Nazim , Abrar Fadlul Azim , Afroz Farhana , Huque Hasna Fahmima , Afroze Samira Rahat 
Published: January 2019

Background and objectives: Low vitamin D is a global problem in all age groups as is osteoporosis in postmenopausal women. The present study was carried out in an urban hospital to assess serum 25-hydroxyvitamin D [25(OH)D] level and bone mineral density (BMD) in postmenopausal women (PMW) and to evaluate correlation between serum 25(OH)D levels and BMD.
Methods: A single center cross-sectional study was conducted among 133 apparently healthy PMW aged 45 years and above with the history of complete cessation of menstruation over a period of more than 1 year. Serum 25(OH)D, BMD and serum intact parathyroid hormone (iPTH) were determined. Patients having both vitamin D and BMD values were analyzed for correlations. Similarly, correlation of vitamin D, iPTH and BMD were determined.
Results: Among the study population, 63 (47.4%) had deficient (<20 ng/ml), 46 (34.6%) had insufficient (20-30ng/ml) and 24(18%) had sufficient (30-100ng/ml) levels of serum 25(OH)D. Among the 121 patients whose BMD was done, 52 (43.0%) and 60 (49.6%) had osteoporosis and osteopenia respectively. Serum iPTH levels were normal in 34 (89.5%) patients. The proportion of osteopenia and osteoporosis in vitamin D deficient group were 44.1% and 50.8% and in insufficient group 47.5 and 45.0%, respectively. Age had significant negative correlation with BMD value (r=-0.246, p=.005) and significant positive correlation with serum iPTH (r=0.358, p=.024). There was no statistically significant influence of serum 25(OH)D or iPTH on occurrence of osteoporosis (P=0.322 and P=0.592 respectively).
Conclusion: A large proportion of postmenopausal women had low vitamin D levels and as well as osteopenia and osteoporosis. Low vitamin D level coexisted with low BMD. However, there was no correlation between serum 25(OH)D levels and BMD status.
IMC J Med Sci 2018; 12(2): 44-49