bluuebunny/crossref_metadata_2025_split huggingface dataset:
An unexpected bronchoscopic finding possibly induced by extracorporeal membrane oxygenation: A case report of bronchial Dieulafoy disease
Authors: Lv Xiaochun , Hu Caibao , Xu Qianghong , Fang Min 
Published: November 2024

Rationale:
Bronchial Dieulafoy disease (BDD), a rarely reported disease, comes from dilated or abnormal arteries under the bronchial mucosa. Patients with BDD are generally asymptomatic so this disease is frequently misdiagnosed. However, the submucosal arteries may dilate and rupture for various reasons, leading to recurrent respiratory tract bleeding and potentially life-threatening conditions. With the change of reversible factors such as intravascular pressure, the arteries may return to normal, allowing patients to recover to an asymptomatic state. This phenomenon has not been mentioned and concerned in previous studies, but it may have important implications for our correct understanding of this disease.

Patient concerns:
A 44-year-old female was admitted to intensive care unit with recurrent malignant arrhythmias. With the assistance of VA-extracorporeal membrane oxygenation (ECMO), both her vital signs and internal environment were all gradually stabilized. However, she had been experiencing recurrent respiratory tract bleeding. While removing the bloody secretion with a fiber bronchoscopy, a congested protruding granule on the wall of the patient’s left principal bronchus was found.

Diagnosis:
The patient was diagnosed with BDD and the granule was thought to be an abnormal artery of BDD.

Interventions:
For the patient’s condition, we did not implement any targeted interventions with the abnormal artery.

Outcomes:
After the weaning of VA-ECMO, the patient’s granule could not be found and the bleeding had also disappeared. She gradually weaned off the mechanical ventilation and was transferred to the Department of Cardiology. Then the patient was discharged after her condition stabilized. In more than half a year, the patient is in a normal physical condition.

Lessons:
The appearance and disappearance of abnormal artery is an interesting phenomena of BDD. The change of intravascular pressure due to various causes such as VA-ECMO may be the primary factor of it.
Effect of vitamin D supplementation on cardiovascular outcomes: an updated meta-analysis of RCTs
Authors: Mirza Agha M.W. , Almansouri Naiela E. , Muslim Muhammad F. , Basheer Thahaseen , Uppalapati Sree V. , Lakra Swati , Fatima Hareem , Adhnon Arshiya , Filho Ivo W. , Mahmood Ruqeyya , Kumar Mahendra , Kandel Kamal , Ayyan Muhammad 
Published: November 2024

Objective:
To evaluate the effect of vitamin D supplementation on cardiovascular outcomes.

Methods:
After searching different databases, we retrieved and included randomized controlled trials on long-term supplementation of vitamin D (≥1-year intervention) and reporting cardiovascular outcomes. We calculated risk ratio (RR) with 95% confidence intervals (CI) for dichotomous outcomes.

Results:
Compared to the control group, the vitamin D group was not associated with a statistically significant decrease in the incidence of major adverse cardiovascular events (MACE) [risk ratio=0.99; 95% CI: 0.94–1.03]. We found no difference between the vitamin D group and the control group for the outcomes of incidences of myocardial infarction, heart failure, coronary revascularization, cardiovascular death, and all-cause mortality. The heterogeneity was low for all outcomes.

Conclusion:
According to our meta-analysis, vitamin D supplementation did not reduce major adverse cardiovascular events, other cardiovascular parameters, and all-cause mortality.
Functional outcomes of tension band wiring versus hook plating in displaced, closed, and isolated distal clavicle fractures in adults: a comparative retrospective study
Authors: Eskandar Mohammad , Saed Maen , Yusuf Safwan 
Published: November 2024

Introduction:
Clavicle fractures are common among young people, generally as a consequence of car accidents, bike falls, and contact sports injuries. 15–20% of all clavicle fractures involve the lateral end of the bone. Thus, the distal clavicle fractures, in particular, have a high non-union rate ranging from 21 to 33% when treated non-operatively, underscoring the usual advice for operative treatment. While significant research has been conducted on clavicle fractures and their treatment options, no definitive guidelines or optimal approaches have been established. Hence, the aim of this study was to assess the clinical and radiological results of the two highly used surgical techniques, Tension Band Wiring (TBW) and Hook plate ones, in addition to investigating the associated functional recovery and outcomes.

Methods:
Between August 2019 and 2022, An analytical retrospective comparative study, was done on 38 patients (20 TBW and 18 Hook plate) diagnosed with unstable fracture of the lateral third of clavicle (Neer 2), aged between 18 and 65 years old, and followed up for more than 12 months.

Results:
TBW technique was used in 20 patients (14 males and 6 females) with mean age 39.25 years and Hook plate was used in 18 patients (14 males,4 females) with mean age of 43.11 years. The union rate was 100% in Hook plate group and 95% in TBW group. The mean time of bony union to occur was (9.55) weeks in TBW group and (8.94) weeks in Hook plate group. The mean of constant–Murley score in the last follow-up was 85.32 in the TBW group and 87.38 in the Hook plate group. superficial infection occurred in 3 cases in TBW group (15%). Four patients complained of impingement, three patients complained of acromial erosion and one patient complained of acromial osteolysis in the Hook plate group.

Conclusion:
Both TBW and Hook plate are a good choice for the fixation of displaced distal clavicle fractures with good functional and radiological outcomes, where Hook plate have some advantages such as rigid fixation and early motion of the affected shoulder.
Dandy–Walker syndrome: a bibliometric analysis of the most 100 cited articles
Authors: Alrefaie Khadeja , Jawed Noyan , Saleh Aalaa , Shibli Farah , Almealawy Yasser F. , Alrubaye Sura N. , Andrew Awuah Wireko , Abdul-Rahman Toufik , Chaurasia Bipin , Atallah Oday 
Published: November 2024

Introduction:
Dandy–Walker syndrome (DWS), a complex neurodevelopmental disorder, has intrigued clinicians and researchers since its description by physicians Walter Dandy and Arthur Walker. Despite its recognition for nearly a century, understanding its etiology, pathogenesis, and clinical manifestations remains elusive. This bibliometric analysis aims to elucidate influential academic works on DWS.

Methods:
In January 2024, the authors conducted a Scopus search for articles on DWS and identified the top 100 referenced publications. The Harzing Publish or Perish search engine was utilized with relevant terms, including ‘Dandy-Walker’, ‘Dandy-Walker Syndrome’, and ‘Dandy-Walker Malformation’. Data from Scopus, including publication details and citation counts, were compiled and organized using Microsoft Excel. Statistical analysis and data visualization were performed using Python, with Pandas, Matplotlib, Seaborn, and NetworkX libraries employed for this purpose.

Results:
The bibliometric analysis of DWS research revealed key insights. Significant research output was noted in the 2000–2009 and 1990–1999 decades. The cumulative citations totaled 6059, with an average of 2.60 citations per year per article. Leading authors included W B Dobyns, Kathleen J Millen, and G Pilu. Institutions such as the University of California and Harvard Medical School were prominent, with the United States being the predominant contributor. Major journals like the American Journal of Medical Genetics played significant roles.

Conclusion:
This bibliometric study summarizes the most-cited articles on DWS, providing light on the field and its seminal works that have shaped both present-day clinical treatment and the trajectory of future research.
An environmental scan of limb loss rehabilitation centers across Canada
Authors: Hitzig Sander L. , Zidarov Diana , MacKay Crystal , Dilkas Steven , Alshehri Fayez , Russell Rachel , Rios Jorge , O'Connell Colleen , Hebert Jacqueline S. , Underwood Heather A. , King Sheena , Zucker-Levin Audrey , Habra Natalie , Andrysek Jan , Viana Ricardo , Payne Michael W. , Hunter Susan W. , Dudek Nancy L. , Best Krista L. , Mercier Catherine , Noonan Vanessa K. , Katz Joel , Pousett Brittany Mae , Walker Jan , Miller William C. , Mayo Amanda L. 
Published: November 2024

Background:
The clinical landscape of limb loss rehabilitation across Canada is poorly delineated, lacks standard rehabilitation guidelines, and is without a shared clinical database.

Objective:
To address these gaps, the objective of the present study was to undertake an environmental scan of the rehabilitation centers across Canada that provide inpatient and/or outpatient services to the limb loss community.

Study Design:
An environmental scan was conducted to describe the rehabilitation service structure, program services, and outcome measures of sites across Canada.

Methods:
A survey was sent to 36 rehabilitation centers providing care to people with amputations.

Results:
Of the 36 centers, 31 completed the survey (11 = Ontario; 8 = Quebec; 6 = British Columbia; 2 = Saskatchewan; 2 = New Brunswick; 1 = Alberta; 1 = Manitoba). Twenty-five provided both inpatient and outpatient services, 1 provided inpatient care only, and 5 provided only outpatient services. Interprofessional services were provided to a wide range of upper extremity amputation and lower extremity amputation patient populations. Range of motion was the most commonly collected outcome for both patients with upper extremity amputation and lower extremity amputation. With regard to prosthetics and orthotics fabrication, 9 of the sites had these services on-site while 15 had off-site fabricators, 6 had both, and 1 provided no response.

Conclusions:
Our findings highlight that limb loss rehabilitation and prosthetic care delivery is variable across Canada with respect to clinical team members, locations of services, and complementary services such as mental health treatments and peer support groups.
Higher non-HIV-comorbidity burden in long-term survivors
Authors: Vonder Thom W. , Mudrikova Tania 
Published: November 2024

Objective:
The possible differences in comorbidity burden were examined between people with longstanding HIV infection and those with shorter HIV duration of the same calendar age.

Design:
We performed a single-centre retrospective cohort analysis comparing long-term HIV survivors (LTS) diagnosed with HIV before 1996 (pre-HAART), with an age-matched and gender-matched group diagnosed after 2006 [modern ART era (mART)].

Methods:
Demographic and outcome data up to 1 May 2023 were obtained from electronic health records as well as from digitalized paper charts. Nine comorbidity domains were defined to overlook the comorbidity burden as on 1 May 2023: cardiovascular, musculoskeletal, neurological, oncological, liver, pulmonary, renal, psychiatric/cognitive, and metabolic.

Results:
Eighty-eight LTS and 88 people diagnosed in the modern ART era were included in the analysis. Median age in both groups was 60 years. LTS had a higher mean number of comorbidity domains than controls (2.6 vs. 1.9; P = .001). In both LTS and mART groups, metabolic and cardiovascular comorbidity was most prevalent (metabolic 70.5 and 52.3%, respectively, cardiovascular 44.3 and 38.6%, respectively). When stratified according to age, the distribution of the number of comorbidities for LTS roughly resembled the 10 years older mART subgroup. In a multivariate analysis, total ART duration and age were found to be statistically significantly associated with the number of comorbidity domains.

Conclusion:
Our analysis suggests that LTS have a higher comorbidity burden compared with people diagnosed in the modern ART era of similar calendar age.
Insights Into Facial Surgery Trends in the United States in the Setting of Gender Dysphoria: A National Analysis From 2012 to 2019
Authors: Hinson Chandler , Palacios Christian , Camacho Justin M. , Stoffel Victoria , Patel Heli , Kohan Joshua , Brandel Michael G. , Reid Chris M. , Gosman Amanda A. 
Published: November 2024

Introduction:
Over the past decade, there has been an improvement in access to gender-affirming surgical care for the transgender population. Even with improvements, this population continues with a high level of inequity among access to specialized surgical care. While multiple studies have previously focused on trends among top and bottom surgery, this study provides trends specifically among facial gender affirmation surgery (FGAS) within the United States.

Methods:
The National Inpatient Sample (NIS) was utilized to identify patients who underwent FGAS from 2012 to 2019. The diagnostic codes for gender identity disorder and gender dysphoria were used to identify the desired patient population. CPT coding released in a medical policy for transgender care coverage was used to identify those who underwent FGAS. Frequency distributions from the patient population were analyzed to determine differences among characteristics.

Results:
In total, 660 patients underwent FGAS from 2012 to 2019. The incidence of FGAS has increased by 1433%. Geographically, FGAS was more likely to be performed in the West and Northeast geographical regions (P<0.0001). There was a statistically significant difference in hospital length of stay and the total number of charges when stratified by race (P<0.0001 and P=0.0003), hospital location (P<0.0001 and <0.0001), and insurance type (P<0.0001 and <0.0001). The largest cohort of patients paid out-of-pocket (P<0.0001).

Conclusions:
FGAS is one of the fastest-growing GAS procedures. Currently, FGAS procedures are not equally distributed, with higher concentrations occurring among wealthier, white individuals in certain geographical regions. Future studies are warranted to understand further trends within FGAS.
Plastic Surgery Contributions to the World Wars: Historical Foundations for Modern Craniofacial Techniques
Authors: Treger Dylan , Taylor Ruby , Prasad Soumil , Thaller Seth R. 
Published: November 2024

Introduction:
Plastic surgery played a crucial role during the World Wars. Surgeons dedicated their careers to reconstructing facial injuries and residual deformities incurred during combat. Times of unprecedented trauma led to rapid innovation in plastic surgery, with invaluable impact on practice today. Pioneers such as Harold Gillies are well-known for their work. There are numerous additional contributors who deserve wider recognition.

Methods:
A literature review was performed to identify key surgeons who treated soldiers’ craniofacial injuries during World Wars I and II. Biographical information, country of practice, and technical contributions to plastic surgery were compiled.

Results:
Nineteen plastic surgeons were identified who contributed significantly to craniofacial surgery during the World Wars. These surgeons were: Albéric Pont, Archibald Mcindoe, Arthur Mowlem, Harold Gillies, Hippolyte Morestin, James Barrett Brown, Jaques Joseph, Johannes Esser, John Staige Davis, John Reese, Otto Lanz, Paul Tessier, Robert Ivy, Suzanne Blanche Gros Noël, Thomas Kilner, William Kelsy Fry, Varaztad H. Kazanjian, Vilray P. Blair, and Vladimir Petrovich Filatov. Fourteen were active during WWI. Nine were active during WWII. Notable technical developments were made in maxillofacial fracture fixation, bone grafting, rhinoplasty, dental prosthetics, flap-based coverage, skin grafting, and burn reconstruction.

Conclusion:
Plastic surgeons played an unheralded role in managing the disfiguring craniofacial injuries of World Wars I and II. By treating tens of thousands of war victims, these surgeons contributed not only to the rehabilitation of soldiers but also to the advancement of craniofacial surgery and the establishment of plastic surgery as a distinct subspecialty.
Surgical Innovation in Serial Reconstruction of Micrognathia Using Free Fibular Flap: Insights From a Study and Literature Review
Authors: Bangun Kristaninta , Atmodiwirjo Parintosa , Tania Vika , Pancawati Julieta , Turnip Gita Amelia , Larasati Anjani 
Published: November 2024

Background:
Free fibular flap (FFF) is the main modality in the reconstruction of maxillofacial defects. Micrognathia is a condition where the mandible is smaller than it should be. Micrognathia is typically treated with mandibular distraction osteogenesis, bilateral sagittal split osteotomy, and conventional costochondral graft. In cases in which these procedures cannot be performed, FFF becomes a suitable alternative. Publications regarding the use of FFF in cases of micrognathia are currently still limited. In this case, we present the use of FFF in the reconstruction of a severely micrognathic mandible in an adult patient.

Case Presentation:
A 28-year-old woman with micrognathia was referred to Dr. Ciptomangunkusumo Hospital for reconstruction. The patient had previously undergone temporomandibular joint (TMJ) reconstruction surgery with interpositional TMJ arthroplasty 10 years prior due to an ankylosing TMJ that prevented the opening of the jaw. The treatment for ankylosing TMJ was necessitated due to the patient’s inability to open their mouth, resulting in significant challenges with alimentation, speech, and facial morphology. Here the authors reported mandibular lengthening reconstruction in the anteroposterior axis with FFF. A surgical osteotomy was performed on the posterior segment of the bilateral mandibular ramus, then the segmented fibula was inserted into the resulting defect. Flap refinement was also performed following FFF. Postsurgical evaluation revealed notable enhancements in the patient’s esthetic appearance, occlusal function, and amelioration of obstructive sleep apnea symptoms.

Conclusions:
FFF for mandibular reconstruction is feasible and effective in improving esthetic and functional outcomes in patients with micrognathia.
Multi-context seeds enable fast and high-accuracy read mapping
Authors: Tolstoganov Ivan , Martin Marcel , Sahlin Kristoffer 
Published: November 2024

AbstractA key step in sequence similarity search is to identify seeds that are found in both the query and the reference sequence. A seed is a shorter substring (e.g., ak-mer) or pattern (e.g., a spacedk-mer) constructed from the sequences. A well-known trade-off in applications such as read mapping is that longer seeds offer fast searches through fewer spurious matches but lower sensitivity in variable regions as longer seeds are more likely to harbor mutations. Some recent developments on seed constructs have considered approximate (or fuzzy) seeds such ask-min-mers, strobemers, BLEND, SubSeqHash, TensorSketch, and more, that can match over smaller mutations and, thus, suffer less from sensitivity issues in variable regions. Nevertheless, the sensitivity-to-speed trade-off still exists for such constructs. In other applications, such as genome assembly, using multiple sizes ofk-mers is effective. While this can be achieved in read mapping through, e.g., MEM construction from an FM-index, such seed constructs are typically much slower than hash-based constructs.To this end, we introduce multi-context seeds (MCS). In brief, MCS are strobemers where the hashes of individual strobes are partitioned in the hash value representing the seed. Such partitioning enables a cache-friendly approach to search for both full and partial matches of a subset of strobes. For example, both the full strobemer and the first strobe (ak-mer) can be queried. We demonstrate that MCS improves sequence matching statistics over standard strobemers andk-mers without compromising seed uniqueness. We demonstrate the practical applicability of MCS by implementing them in strobealign. Strobealign with MCS comes at no cost in memory and only little cost in runtime while offering increased mapping accuracy over default strobealign using simulated Illumina reads across genomes of various complexity. We also show that strobealign with MCS outperforms minimap2 in short-read mapping and is comparable to BWA-MEM in accuracy in high-variability sequences. MCS provides a fast seed alternative that addresses the trade-offs between seed length and alignment accuracy.
COMPARISON OF UNIVARIATE AND MULTIVARIATE REFERENCE INTERVAL METHODS
Authors: Mergen Esra Kutsal , Karahan Sevilay 
Published: November 2024

ABSTRACTBackgroundIn clinical practice, reference intervals play a pivotal role in interpreting laboratory test results. Yet, when several tests are taken into consideration simultaneously, the traditional univariate intervals might not suffice due to the elevated risk of Type 1 errors.MethodsThis study introduces and evaluates two multivariate reference interval techniques: one based on Mahalanobis distance and the other an adaptation of the multivariate confidence interval. Using Monte Carlo simulations, we focused our assessments on the interplay between “Serum Ferritin and Transferrin Saturation” values.ResultsUpon evaluation, it became evident that the multivariate methods significantly reduced false positives. They presented enhanced accuracy over traditional univariate intervals. Notably, the method involving Mahalanobis distance stood out in terms of efficacy.ContributionsBeyond presenting novel techniques, our research underscores the importance and potential of using multivariate approaches in clinical lab settings. The findings can guide better medical decision-making, ensuring optimized allocation of healthcare resources.HighlightsWe present two alternative multivariate reference interval methods that consider the relationship between two analytes simultaneously.Through comprehensive simulation studies, we compare the proposed methods with the conventional univariate reference interval method.Our results show the superior performance of our proposed methods in terms of patient rate, sensitivity, specificity, and overall accuracy.We discuss the practical relevance of these new methods.
Enhancing Ischemic Stroke Management: Leveraging Machine Learning Models for Predicting Patient Recovery After Alteplase Treatment
Authors: Khorsand Babak , Vaghf Atena , Salimi Vahide , Zand Maryam , Ghoreishi Seyed Abdolreza 
Published: November 2024

AbstractAimIschemic stroke remains a leading global cause of morbidity and mortality, emphasizing the need for timely treatment strategies. This study aimed to develop a machine learning model to predict clinical outcomes in ischemic stroke patients undergoing Alteplase therapy, thereby supporting more personalized care.MethodsData from 457 ischemic stroke patients were analyzed, including 50 demographic, clinical, laboratory, and imaging variables. Five machine learning algorithms—k-nearest neighbors (KNN), support vector machines (SVM), Naïve Bayes (NB), decision trees (DT), and random forest (RF)—were evaluated for predictive accuracy. The primary evaluation metrics were sensitivity and F-measure, with an additional feature importance analysis to identify high-impact predictors.ResultsThe Random Forest model showed the highest predictive reliability, outperforming other algorithms in sensitivity and F-measure. Furthermore, by using only the top-ranked features identified from the feature importance analysis, the model maintained comparable performance, suggesting a streamlined yet effective predictive approach.ConclusionOur findings highlight the potential of machine learning in optimizing ischemic stroke treatment outcomes. Random Forest, in particular, proved effective as a decision-support tool, offering clinicians valuable insights for more tailored treatment approaches. This model’s use in clinical settings could significantly enhance patient outcomes by informing better treatment decisions.