bluuebunny/crossref_metadata_2025_split huggingface dataset:
The youth of antiquity: reception, homosexuality, alterity
Authors: Butler Shane 
Published: June 2019

AbstractClassical reception studies and the Foucault-inflected study of ancient homosexuality came of age together, sharing several key dates in their core bibliographies. This article argues that this synchronicity is no coincidence. In particular, both endeavours have been driven by remarkably similar views of the ‘otherness’ of the past itself. Arguing that this view has partly been motivated by unspoken anxieties about scholarly agency, this article sheds some critical light on the presuppositions and methods of both subfields. It also aims to signpost some better, queerer ways forward, borrowed from the past itself.
Hemispheric Asymmetries in Deaf and Hearing During Sustained Peripheral Selective Attention
Authors: Gwinn O Scott , Jiang Fang 
Published: June 2019

Abstract
Previous studies have shown that compared to hearing individuals, early deaf individuals allocate relatively more attention to the periphery than central visual field. However, it is not clear whether these two groups also differ in their ability to selectively attend to specific peripheral locations. We examined deaf and hearing participants’ selective attention using electroencephalography (EEG) and a frequency tagging paradigm, in which participants attended to one of two peripheral displays of moving dots that changed directions at different rates. Both participant groups showed similar amplifications and reductions in the EEG signal at the attended and unattended frequencies, indicating similar control over their peripheral attention for motion stimuli. However, for deaf participants these effects were larger in a right hemispheric region of interest (ROI), while for hearing participants these effects were larger in a left ROI. These results contribute to a growing body of evidence for a right hemispheric processing advantage in deaf populations when attending to motion.
Host Plant Salinity Stress Affects the Development and Population Parameters of Nilaparvata lugens (Hemiptera: Delphacidae)
Authors: Quais Md Khairul , Ansari Naved Ahmad , Wang Gui-Yao , Zhou Wen-Wu , Zhu Zeng-Rong 
Published: June 2019

AbstractSalinization is one of the most critical abiotic stress factors for crops and a rising setback in agro-ecosystems. Changes in weather, land usage, and the salinization of irrigation water are increasing soil salinity of many farmlands. Increased soil salinity alters the plant quality, which subsequently may trigger bottom-up effects on herbivorous insect. We examined the bottom-up effect of salinity stress on population parameters of the brown planthopper (BPH), Nilaparvata lugens through rice (Oryza sativa L.) plant. The results revealed that salinity interfered with egg hatching of BPH. The nymphal development period, adult longevity, and oviposition were also influenced by salinity. Notable differences appeared in the intrinsic growth rate (r), the finite increase rate (λ) and the net reproduction rate (R0) of BPH, and a concentration-dependent effect was detected. Although salinity adversely affected BPH development, population projection predicted a successful growth of the BPH population in a relatively short time under the treatment of low and medium levels of salinity (6, 8, and 10 dS/m of NaCl), whereas higher salt concentrations (12 and 14 dS/m) lead to significant fitness costs in BPH populations. Our study predicts that BPH could become a problem in areas with lower and medium salinity and that those planthoppers may exacerbate the negative effects of salinity for rice production. This study will provide valuable information for understanding the field abundance and distribution of BPH on saline rice field, thus contributing to the development of eco-friendly strategies to manage this pest in saline ecosystems.
Zero-hours contracts and labour market policy
Authors: Datta Nikhil , Giupponi Giulia , Machin Stephen 
Published: June 2019

SUMMARYThe evolving nature of atypical work arrangements is studied. A particular focus is placed on one such form of work relation: zero-hours contracts (ZHCs). The paper uses existing secondary data and new survey data collected for the specific purpose of studying alternative work arrangements to describe the nature of ZHC work in the UK labour market. The interaction with labour market policy is explored, in the context of the 2016 introduction of the UK’s National Living Wage. ZHC work is shown to be an important feature of today’s work arrangements, and the wage cost shock induced by the new, higher minimum wage resulted in an increased use of ZHCs in the UK social care sector, and in low wage sectors more generally.
Estimating individual lifetime benefit and bleeding risk of adding rivaroxaban to aspirin for patients with stable cardiovascular disease: results from the COMPASS trial
Authors: de Vries Tamar I , Eikelboom John W , Bosch Jackie , Westerink Jan , Dorresteijn Jannick A N , Alings Marco , Dyal Leanne , Berkowitz Scott D , van der Graaf Yolanda , Fox Keith A A , Visseren Frank L J 
Published: June 2019

Abstract

Aims
Adding rivaroxaban to aspirin in patients with stable atherosclerotic disease reduces the recurrence of cardiovascular disease (CVD) but increases the risk of major bleeding. The aim of this study was to estimate the individual lifetime treatment benefit and harm of adding low-dose rivaroxaban to aspirin in patients with stable cardiovascular disease.

Methods and results
Patients with established CVD from the COMPASS trial (n = 27 390) and SMART prospective cohort study (n = 8139) were used. Using the pre-existing lifetime SMART-REACH model for recurrent CVD, and a newly developed Fine and Gray competing risk-adjusted lifetime model for major bleeding, individual treatment effects from adding low-dose rivaroxaban to aspirin in patients with stable CVD were estimated, expressed in terms of (i) life-years free of stroke or myocardial infarction (MI) gained; and (ii) life-years free from major bleeding lost. Calibration of the SMART-REACH model for prediction of recurrent CVD events in the COMPASS study was good. The major bleeding risk model as derived in the COMPASS trial showed good external calibration in the SMART cohort. Predicted individual gain in life expectancy free of stroke or MI from added low-dose rivaroxaban had a median of 16 months (range 1–48 months), while predicted individualized lifetime lost in terms of major bleeding had a median of 2 months (range 0–20 months).

Conclusion
There is a wide distribution in lifetime gain and harm from adding low-dose rivaroxaban to aspirin in individual patients with stable CVD. Using these lifetime models, benefits and bleeding risk can be weighed for each individual patient, which could facilitate treatment decisions in clinical practice.
Single systemic transfer of a human gene associated with exceptional longevity halts the progression of atherosclerosis and inflammation in ApoE knockout mice through a CXCR4-mediated mechanism
Authors: Puca Annibale Alessandro , Carrizzo Albino , Spinelli Chiara , Damato Antonio , Ambrosio Mariateresa , Villa Francesco , Ferrario Anna , Maciag Anna , Fornai Francesco , Lenzi Paola , Valenti Valentina , di Nonno Flavio , Accarino Giulio , Madonna Michele , Forte Maurizio , Calì Gaetano , Baragetti Andrea , Norata Giuseppe Danilo , Catapano Alberico Luigi , Cattaneo Monica , Izzo Raffaele , Trimarco Valentina , Montella Francesco , Versaci Francesco , Auricchio Alberto , Frati Giacomo , Sciarretta Sebastiano , Madeddu Paolo , Ciaglia Elena , Vecchione Carmine 
Published: June 2019

Abstract

Aims
Here, we aimed to determine the therapeutic effect of longevity-associated variant (LAV)-BPIFB4 gene therapy on atherosclerosis.

Methods and results
ApoE knockout mice (ApoE−/−) fed a high-fat diet were randomly allocated to receive LAV-BPIFB4, wild-type (WT)-BPIFB4, or empty vector via adeno-associated viral vector injection. The primary endpoints of the study were to assess (i) vascular reactivity and (ii) atherosclerotic disease severity, by Echo-Doppler imaging, histology and ultrastructural analysis. Moreover, we assessed the capacity of the LAV-BPIFB4 protein to shift monocyte-derived macrophages of atherosclerotic mice and patients towards an anti-inflammatory phenotype. LAV-BPIFB4 gene therapy rescued endothelial function of mesenteric and femoral arteries from ApoE−/− mice; this effect was blunted by AMD3100, a CXC chemokine receptor type 4 (CXCR4) inhibitor. LAV-BPIFB4-treated mice showed a CXCR4-mediated shift in the balance between Ly6Chigh/Ly6Clow monocytes and M2/M1 macrophages, along with decreased T cell proliferation and elevated circulating levels of interleukins IL-23 and IL-27. In vitro conditioning with LAV-BPIFB4 protein of macrophages from atherosclerotic patients resulted in a CXCR4-dependent M2 polarization phenotype. Furthermore, LAV-BPIFB4 treatment of arteries explanted from atherosclerotic patients increased the release of atheroprotective IL-33, while inhibiting the release of pro-inflammatory IL-1β, inducing endothelial nitric oxide synthase phosphorylation and restoring endothelial function. Finally, significantly lower plasma BPIFB4 was detected in patients with pathological carotid stenosis (&gt;25%) and intima media thickness &gt;2 mm.

Conclusion
Transfer of the LAV of BPIFB4 reduces the atherogenic process and skews macrophages towards an M2-resolving phenotype through modulation of CXCR4, thus opening up novel therapeutic possibilities in cardiovascular disease.
Comparative Genomics of Wild Bee and Flower Isolated Lactobacillus Reveals Potential Adaptation to the Bee Host
Authors: Vuong Hoang Q , McFrederick Quinn S 
Published: June 2019

AbstractSymbiosis with bacteria is common across insects, resulting in adaptive host phenotypes. The recently described bacterial symbionts Lactobacillus micheneri, Lactobacillus timberlakei, and Lactobacillus quenuiae are found in wild bee pollen provisions, bee guts, and flowers but have small genomes in comparison to other lactobacilli. We sequenced, assembled, and analyzed 27 new L. micheneri clade genomes to identify their possible ecological functions in flower and bee hosts. We determined possible key functions for the L. micheneri clade by identifying genes under positive selection, balancing selection, genes gained or lost, and population structure. A host adherence factor shows signatures of positive selection, whereas other orthologous copies are variable within the L. micheneri clade. The host adherence factors serve as strong evidence that these lactobacilli are adapted to animal hosts as their targets are found in the digestive tract of insects. Next, the L. micheneri clade is adapted toward a nutrient-rich environment, corroborating observations of where L. micheneri is most abundant. Additionally, genes involved in osmotolerance, pH tolerance, temperature resistance, detoxification, and oxidative stress response show signatures of selection that allow these bacteria to thrive in pollen and nectar masses in bee nests and in the bee gut. Altogether, these findings not only suggest that the L. micheneri clade is primarily adapted to the wild bee gut but also exhibit genomic features that would be beneficial to survival in flowers.
Determination of ellipsoidal surface mass change from GRACE time-variable gravity data
Authors: Ghobadi-Far Khosro , Šprlák Michal , Han Shin-Chan 
Published: June 2019

SUMMARY
The problem of determining mass redistribution within the Earth system from time-variable gravity (TVG) data is non-unique. Over seasonal and decadal time-scales, mass redistribution likely takes place on the Earth’s surface. By approximating the Earth’s surface by a sphere, surface mass variation can be uniquely determined from TVG data. Recently, using the improved GRACE TVG data, Li et al. and Ditmar found that such spherical approximation is no longer tenable and suggested practical approaches to accommodate the elliptical shape of the Earth. In this study, we develop a rigorous method of determining surface mass change on the Earth’s reference ellipsoid. We derive a unique one-to-one relationship between ellipsoidal spectra of surface mass and gravitational potential for the ellipsoidal geometry. In conjunction with our ellipsoidal formulation, the linear transformation between spherical and ellipsoidal harmonic coefficients of the geopotential field enables us to determine mass redistribution on the ellipsoid from GRACE TVG data. Using the Release 6 of GRACE TVG data to degree 60, we show that the ellipsoidal approach reconciles surface mass change rate significantly better than the spherical computation by 3–4 cm yr−1, equivalent to 10–15  per cent increase of total signal, in Greenland and West Antarctica. We quantify the spherical approximation error over the polar regions using GRACE Level-2 TVG data as well as mascon solutions, and demonstrate that the systematic error increases linearly with the maximum degree used for the synthesis. The terrestrial water storage computation is less affected by the spherical approximation because of geographic location of major river basins (lower latitude) and signal characteristics. The improvement of TVG data from GRACE and its Follow-On necessitates the ellipsoidal computation, particularly for quantifying mass change in polar regions.
Adaptive moment-tensor joint inversion of clustered microseismic events for monitoring geological carbon storage
Authors: Chen Yu , Huang Lianjie 
Published: June 2019

SUMMARY
Moment-tensor inversion of induced microseismic events can provide valuable information for tracking CO2 plumes at geological carbon storage sites, and study the physical mechanism of induced microseismicity. Accurate moment-tensor inversion requires a wide-azimuthal coverage of geophones. Cost-effective microseismic monitoring for geological carbon storage often uses only one geophone array within a borehole, leading to a large uncertainty in moment-tensor inversion. We develop a new adaptive moment-tensor joint inversion method to reduce the inversion uncertainty, when using limited but typical geophone receiver geometries. We first jointly invert a number of clustered microseismic events using a uniform focal mechanism to minimize the waveform misfit between observed and predicted P and S waveforms. We then invert the moment tensor for each event within a limited searching range around the joint inversion result. We apply our adaptive joint inversion method to microseismic data acquired using a single borehole geophone array at the CO2-Enhanced Oil Recovery field at Aneth, Utah. We demonstrate that our inversion method is capable of reducing the inversion uncertainty caused by the limited azimuthal coverage of geophones. Our inverted strikes of focal mechanisms of microseismic events are consistent with the event spatial distribution in subparallel pre-existing fractures or geological imperfections. The large values up to 40 per cent of the CLVD components might indicate crack opening induced by CO2/wastewater injection or rupture complexity.
The influence of inherited continental margin structures on the stress and strain fields of the south-central Taiwan fold-and-thrust belt
Authors: Biete Cristina , Brown Dennis , Lund Björn , Alvarez-Marron Joaquina , Wu Yih-Min , Kuo-Chen Hao , Ho Chun-Wei 
Published: June 2019

SUMMARYIn this paper we test whether or not structural and morphological features inherited from the Eurasian continental margin are affecting the contemporary stress and strain fields in south-central Taiwan. Principal stress directions (σ1, σ2 and σ3) are estimated from the inversion of clustered earthquake focal mechanisms and the direction of the maximum compressive horizontal stress (SH) is calculated throughout the study area. From these data the most likely fault plane orientations and their kinematics are inferred. The results of the stress inversion are then discussed together with the directions of displacement, compressional strain rate and maximum shear strain rate derived from GPS data. These data show that there is a marked contrast in the direction of SH from north to south across the study area, with the direction of SH remaining roughly subparallel to the relative plate motion vector in the north, whereas in the south it rotates nearly 45° counter-clockwise. The direction of the horizontal maximum compression strain rate (εH) and associated maximum shear planes, together with the displacement field display an overall similar pattern between them, although undergoing a less marked rotation. We interpret the southward change in the SH, εH and the dextral maximum shear plane directions, together with that of the horizontal displacement field to be related to the reactivation of east–northeast striking faults inherited from the rifted Eurasian margin and to the shelf/slope break. Inherited faults in the basement are typically reactivated as strike-slip faults, whereas newly formed faults in the fold-and-thrust belt are commonly thrusts or oblique thrusts. Eastwards, the stress inversions and strain data show that the western flank of the Central Range is undergoing extension in the upper crust. SH in the Central Range is roughly parallel to the relative plate convergence vector, but in southwestern Taiwan it undergoes a marked counter-clockwise rotation westwards across the Chaochou fault. Farther north, however, there is no significant change across the Lishan fault. This north to south difference is likely due to different margin structures, although local topographic effects may also play a role.
Community gardens and wellbeing amongst vulnerable populations: a thematic review
Authors: Malberg Dyg Pernille , Christensen Søren , Peterson Corissa Jade 
Published: June 2019

AbstractThe aim of the thematic review is to document the effects of community gardens on wellbeing amongst vulnerable populations. We searched for articles published between 1980 and 2017 in major databases resulting in the inclusion of 51 articles. Vulnerable populations included, amongst others, ethnic minorities and refugees, socioeconomically disadvantaged neighbourhoods or low-income or food insecure families. Our findings suggest that community garden participation may have a positive impact on physical health, such as reducing body weight and hypertension, and increasing physical activity and food knowledge. However, findings relating to community gardens and their potential to enhance food security were inconsistent. Furthermore we found that community gardens can have a positive influence both at the individual level (i.e. self-esteem, independence, personal control, etc.), particularly for refugees; the relational and social level (i.e. relationships, social connections, community and neighbourhood). Community garden participation have the potential to enhance wellbeing amongst vulnerable populations. However, two articles in our review presented potential food safety concerns related to community gardens, indicating that, particularly in urban settings, attention must be given to minimizing potential food safety concerns, e.g. by using raised garden beds. Based on this review, we recommend that further research and evaluation on non-US-based community gardens is carried out, as community gardens are practiced globally but there is little research to document the effects of community gardens on wellbeing amongst vulnerable populations outside of the USA.
Evaluating progress in the uptake and impact of Health Promotion competencies in Europe
Authors: Battel-Kirk Barbara , Barry Margaret M 
Published: June 2019

Abstract
This paper reports on a study undertaken to determine what progress has been made in the uptake and impact of the CompHP Core Competencies on Health Promotion practice, education and training in Europe since their publication in 2011. The study used a purposive sample comprising health promoters who had contributed to the development of the CompHP Competencies was augmented by snowball sampling across European Health Promotion practitioners. An online survey tool was employed to elicit information on respondents' attitudes to the Competencies, levels of current and intended use, and opinions on their impact. A total of 81 responses were received from 25 European countries. Findings on factors considered likely to influence the use of the Competencies were generally positive, as were respondents' attitudes to them. However, only 53% of respondents reported that the CompHP Competencies were used in their country and 54% that they used them in their practice. The Competencies were most frequently used in Health Promotion education, where their impact was also most apparent. A lack of support and recognition of the Competencies by key organizations and stakeholders at country level emerges as a potentially critical factor influencing their uptake and use. The survey findings provide an insight into the uptake and impact of the CompHP Core Competencies to date and begin to address the gap in empirical evidence on the use and impact of Health Promotion competencies. However, further research is required to explore the factors influencing implementation of the CompHP Core Competencies at a country level.
Combining P301L and S320F tau variants produces a novel accelerated model of tauopathy
Authors: Koller Emily J , Gonzalez De La Cruz Elsa , Machula Timothy , Ibanez Kristen R , Lin Wen-Lang , Williams Tosha , Riffe Cara J , Ryu Daniel , Strang Kevin H , Liu Xuefei , Janus Christopher , Golde Todd E , Dickson Dennis , Giasson Benoit I , Chakrabarty Paramita 
Published: June 2019

Abstract
Understanding the biological functions of tau variants can illuminate differential etiologies of Alzheimer’s disease (AD) and primary tauopathies. Though the end-stage neuropathological attributes of AD and primary tauopathies are similar, the etiology and behavioral outcomes of these diseases follow unique and divergent trajectories. To study the divergent physiological properties of tau variants on a uniform immunogenetic background, we created somatic transgenesis CNS models of tauopathy utilizing neonatal delivery of adeno-associated viruses expressing wild-type (WT) or mutant tau in non-transgenic mice. We selected four different tau variants—WT tau associated with AD, P301L mutant tau associated with frontotemporal dementia (FTD), S320F mutant tau associated with Pick’s disease and a combinatorial approach using P301L/S320F mutant tau. CNS-targeted expression of WT and P301L mutant tau results in robust tau hyperphosphorylation without tangle pathology, gradually developing age-progressive memory deficits. In contrast, the S320F variant, especially in combination with P301L, produces an AD-type tangle pathology, focal neuroinflammation and memory impairment on an accelerated time scale. Using the doubly mutated P301L/S320F tau variant, we demonstrate that combining different mutations can have an additive effect on neuropathologies and associated co-morbidities, possibly hinting at involvement of unique functional pathways. Importantly, we also show that overexpression of wild-type tau as well as an FTD-associated tau variant can lead to cognitive deficits even in the absence of tangles. Together, our data highlights the synergistic neuropathologies and associated cognitive and synaptic alterations of the combinatorial tau variant leading to a robust model of tauopathy.