bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of switching from dipeptidyl peptidase-4 inhibitors to dulaglutide in patients with type 2 diabetes
Authors: Chiba Koki , Oita Mayuko , Nakamura Hiroyuki , Utsunomiya Ayano , Kosumi Yui , Iesaka Hiroshi , Watanabe Toshiyuki , Horita Tetsuya 
Published: August 2019

Abstract
Background:
Several reports showed that the effects of daily Glucagon-like peptidase-1 (GLP-1) receptor agonists for lowering plasma glucose and body weight are superior to those of dipeptidyl peptidase-4 (DPP-4) inhibitors, while the superiority of weekly GLP-1 receptor agonists, dulaglutide, is still unclear. The aim of this study was to evaluate the efficacy of dulaglutide therapy switching from DPP-4 inhibitors in patients with type 2 diabetes.
Methods:
We retrospectively evaluated the 79 Japanese patients with type 2 diabetes at the Diabetes Outpatient Clinic in Tomakomai City Hospital whose treatment was switched from DPP-4 inhibitors to dulaglutide. We investigated the change of hemoglobin A1c (HbA1c), casual plasma glucose (CPG) levels and body weight 4 weeks, 8 weeks and 12 weeks after switching from DPP-4 inhibitors to dulaglutide. In addition, we defined the group in which HbA1c was improved more than 1% as “improved group” (n = 37) and the group in which HbA1c was improved less than 1% as “non-improved group” (n = 42), and compared the patients’ background in both the groups. The subtraction of HbA1c at each weeks and baseline HbA1c was defined as ⊿HbA1c.
Results:
After switching to dulaglutide, HbA1c showed a significant decrease from 4 weeks later, and the effect was maintained even after 12 weeks. The “improved group” had lower estimated glomerular filtration rate (eGFR) and higher baseline HbA1c than the “non-improved group”. In the “improved group”, ⊿HbA1c showed a significant correlation with eGFR and baseline HbA1c.
Conclusion:
Switching from DPP-4 inhibitors to dulaglutide could improve HbA1c, especially in cases with low eGFR and high HbA1c.
Participation of adults with cognitive, physical, or psychiatric impairments in family of origin and intimate relationships: a grounded theory study
Authors: Pfister Andreas , Georgi-Tscherry Pia , Berger Fabian , Studer Michaela 
Published: August 2019

Abstract
Background

How adults with disabilities perceive participation has received little attention. Our purpose was to formulate a grounded theory on participation, based on the subjective experience of adults with cognitive, physical, or psychiatric impairment(s), and to identify barriers, facilitators, and support needs concerning participation in different areas of life. We aimed to explore whether the United Nations’ Convention on the Rights of Persons with Disabilities (CRPD), ratified by Switzerland in 2014, and its principles are being met. Here we report on the main category and focus on the participation areas ‘family of origin’ and ‘intimate relationships.’

Methods

In a qualitative, grounded theory study, we conducted problem-centered interviews with 23 adults with cognitive, physical, or psychiatric impairments (30­-53 years; 11 men, 12 women), with different housing (on their own, assisted living, with parents) and work situations (primary vs. secondary labor market) in nine German-speaking Swiss cantons.

Results

Participation can be understood as a continuum that extends on a horizontal level (from participation is restricted to participation takes place) and a vertical level (separative setting vs. inclusive setting). In separative as well as in inclusive settings, diverse levels of participation are possible. Many participants were stuck in an ‘in-between’ area between separative and inclusion-oriented settings. In the family of origin, there was a thin line between fulfilling relations that enhance participation and conflictual relations and overprotective parenting that limit participation. In intimate relationships, opportunities for participation were limited overall. Many interviewees were single. Social environment and family of origin (e.g., parents) can enable and facilitate intimate relationships and sexual contacts but can also be an important barrier.

Conclusions

Participation can be understood as a continuum. Participation restrictions exist in separative as well as in inclusive-oriented settings, also in the areas of family of origin and intimate relationships. Participation barriers must be torn down in separative as well as in inclusion-oriented settings. Trajectories to inclusive settings should be facilitated. Families with children with impairment(s) should be accompanied from early on to create the best possible participation possibilities for the (adult) person with impairment(s) and to support the family of origin itself.
Breastfeeding Knowledge, Attitude, and Practice among White-Collar and Blue-Collar Workers in Indonesia
Authors: Basrowi Ray Wagiu , Sulistomo Astrid W , Adi Nuri Purwito , Widyahening Indah S , Vandenplas Yvan 
Published: August 2019

Abstract
Objective

Working status is identified as a major risk factor of poor breastfeeding practices among workers. This study aimed to evaluate the knowledge, attitude, and factors associated to breastfeeding practice among white-collar and blue-collar workers in Indonesia.

Methods

A cross-sectional study was performed in two factories and three government offices in Jakarta from December 2012 to February 2013. Subjects were female workers whose children aged 6 months to 24 years old and actively working in the factory and/or office. The factors studied were selected socio-demographic and occupational characteristics, score on knowledge and attitude and breastfeeding practice during working hours.

Results

From a total of 192 subjects, 73% of white-collar workers had good knowledge on breastfeeding, in contrast with 55% of blue-collar workers who had not good of breastfeeding knowledge (P<0.001). Most of the subjects were conducting breast pumping during working hours, however 15% of white-collar worker and 17% of blue-collar worker were never breastfeed nor breast pumping at work. Working status (P=0.005) and knowledge (P=0.002) were factors associated with breastfeeding practice among workers.

Conclusion

White-collar workers have a better knowledge, attitude, and practice toward breastfeeding. Knowledge improvement related to breastfeeding benefits and supports to working mothers are key priority, however advocacy to employers, manager, and supervisor in providing breastfeeding facilitations and programs support were also critical to successful breastfeeding practice among workers.
Effect of yoga on sleep quality in women: a systematic review and meta-analysis
Authors: Wang Weili , Chen Kuang-Huei , Pan Ying-Chieh , Yang Szu-Nian , Chan Yuan-Yu 
Published: August 2019

Abstract
Objectives

To examine the effectiveness and safety of yoga for women with sleep problems by performing a systematic review and meta-analysis.

Methods

Medline/PubMed, Clincalkey, ScienceDirect, Embase, PsycINFO, and the Cochrane Library were searched throughout the month of June 2019. Randomized controlled trials comparing yoga groups with control groups in women with sleep problems were included. Two reviewers independently evaluated risk of bias by using the risk of bias tool suggested by the Cochrane Collaboration for programming and conducting systematic reviews and meta-analyses. The main outcome measure was sleep quality, which was measured using subjective instruments, such as the Pittsburgh Sleep Quality Index (PSQI), or objective instruments, such as polysomnography, actigraphy, and safety of the intervention. For each outcome, standardized mean difference (SMD) and 95% confidence intervals (CIs) were determined.

Results

Nineteen studies including 1832 participants were included in this systematic review. Meta-analyses revealed positive effects of yoga using PSQI or ISI scores in 16 randomized control trials (RCTs) compared with the control group in improving sleep quality in women, PSQI (SMD = −0.42; 95% CI = −0.76 to −0.09 ; P = 0.01). However, three RCTs revealed no effects of yoga compared with the control group in improving sleep quality in women using ISI (SMD = −0.13; 95% CI = −0.74 to 0.48; P = 0.69). Seven RCTs revealed no evidence for effects of yoga compared with the control group in improving sleep quality for women with breast cancer using PSQI (SMD = −0.15 ; 95% CI = −0.31 to 0.01; P = 0.5). Four RCTs revealed no evidence for the effects of yoga compared with the control group in improving the sleep quality for peri-or postmenopausal women using PSQI (SMD = −0.31; 95% CI = −0.95 to 0.33; P = 0.34).Yoga was not associated with serious adverse events.

Discussion

This systematic review and meta-analysis found that yoga intervention in various groups of women was beneficial in managing sleep problems. Despite certain disadvantages in methodology in the included studies, yoga may be recommended as an additional therapy to women in addition to pharmacological treatment.
Service user and family participation in mental health policy making in Timor-Leste: a qualitative study with multiple stakeholders
Authors: Hall Teresa , Kakuma Ritsuko , Palmer Lisa , Minas Harry , Martins João , Armstrong Greg 
Published: August 2019

Abstract
Introduction
Participation in mental health system strengthening by people with mental health problems and their families is a cornerstone of people-centred mental health care, yet there is a dearth of research about participation from low- and middle-income countries (LMICs), particularly from the Asia Pacific region. Hence, this study aimed to assess the current situation, challenges, enabling factors and future actions for service user and family participation in mental health policy making in Timor-Leste.
Methods
In-depth interviews were conducted with 85 adults (≥18 years) who were: (1) mental health service users (n = 20) and their families (n = 10); (2) government decision makers (n = 10); (3) mental health and social service providers (n = 23); (4) civil society (n = 9); and (5) other groups (n = 13). Interview data was analysed using framework analysis.
Results
There was limited service user, family and community participation in mental health policy making in Timor-Leste. Perceptions that policy making is a technical exercise and that people with mental health problems lack cognitive capacity, and a lack of supportive mechanisms challenged participation. Enabling factors were a strong focus on human rights within the social sector, and existing mechanisms for advocacy and representation of people with disabilities in social policy making. Participants suggested bolstering civil society representation of people with mental health problems, and increasing mental health awareness and literacy, including government competencies to facilitate service user participation.
Conclusion
The findings highlight the need for theoretical and practical focus on the role of family within mental health system development in LMICs. Global mental health research and practice should adopt a critical approach to mental health service user and family participation to ensure that the concept and strategies to achieve this are embedded in LMIC knowledge.
A partial mediation effect of father-child attachment and self-esteem between parental marital conflict and subsequent features of internet gaming disorder in children: a 12-month follow-up study
Authors: Jeong Hyunsuk , Yim Hyeon Woo , Lee Seung-Yup , Lee Hae Koo , Potenza Marc N , Jo Sun-jin , Son Hye Jung 
Published: August 2019

Abstract
Objectives
This study evaluated whether parent-child attachment and self-esteem may mediate a relationship between parental marital conflict and increases in features of internet gaming disorder (IGD) in children at one year.
Method
Baseline and one-year follow-up data for 268 children from the iCURE study were collected. The students were “non-cases of high risk of IGD” in the initial self-reported assessment, anyone living with both parents, current game users at baseline, and those who completed a 12-month follow-up assessment. The Internet Game Use-Elicited Symptom Screen (IGUESS) was used to identify increases in IGD features at 12 months. To examine a potential mediation effect, structural equation modeling was performed.
Results
The direct effect was statistically significant, and parental marital conflict at baseline significantly predicted increases in IGD features in children at the 12-month follow-up after adjusting for gender, sex, socioeconomic status, and baseline IGUESS score (ß=0.206, P=0.003). The indirect effect showed that attachment to fathers through self-esteem was a significant mediating effect (ß=0.078, P=0.045). However, attachment to mothers through self-esteem was not a statistically significant mediating effect. The effect of parental conflict on increases in IGD features in children was partially mediated by father-child attachment through self-esteem.
Conclusion
Parental marital conflicts is associated with increases in IGD features in children through poor father-child attachment, and in turn, lower levels of self-esteem in the children. Parents, especially fathers, should make an effort to bond with their children to reduce the risk their children will develop IGD features.

Keywords: Internet gaming disorder; children; mediation; self-esteem; attachment
Knowledge, attitudes and practices of South Asian immigrants in developed countries regarding oral cancer: An integrative review
Authors: Saraswat Nidhi , Pillay Rona , Everett Bronwyn , George Ajesh 
Published: August 2019

Abstract
Background

Oral cancer is a growing problem worldwide, with high incidence rates in South Asian countries. With increasing numbers of South Asian immigrants in developed countries, a possible rise in oral cancer cases is expected given the high prevalence in their source countries and the continued oral cancer risk behaviours of immigrants. The aim of this review is to synthesise existing evidence regarding knowledge, attitudes and practices of South Asian immigrants in developed countries regarding oral cancer.

Methods

Four electronic databases were systematically searched to identify original, English language articles focussing on oral cancer risk knowledge, attitudes and practices of South Asian immigrants in developed countries. All studies that met the following inclusion criteria were included: conducted among South Asian immigrants in developed countries; explored at least one study outcome (knowledge or attitudes or practices); used either qualitative, quantitative or mixed methods. No restrictions were placed on the publication date, quality and setting of the study.

Results

A total of 14 studies involving 4224 participants were reviewed. These studies were mainly conducted in the USA, UK, Italy and New Zealand between 1994-2018. Findings were categorised into themes of oral cancer knowledge, attitudes and practices. General lack of oral cancer knowledge (50%-76%) among participants was reported. More than 50% people were found engaging in one or more oral cancer risk practices like smoking, betel quid/pan/guthka chewing. Some of the participants perceived betel quid/pan/guthka chewing habit good for their health (12%-43.6%).

Conclusion

This review has shown that oral cancer risk practices are prevalent among South Asian immigrants who possess limited knowledge and unfavourable attitude in this area. Culturally-appropriate targeted interventions and strategies are needed to raise oral cancer awareness among South Asian communities in developed countries.
Neoadjuvant chemotherapy-induced decrease of prognostic nutrition index predicts poor prognosis in patients with breast cancer
Authors: Oba Takaaki , Maeno Kazuma , Takekoshi Daiya , Ono Mayu , Ito Tokiko , Kanai Toshiharu , Ito Ken-ichi 
Published: August 2019

Abstract
Background

The prognostic nutritional index (PNI), which is an easily calculated nutritional index, is significantly associated with patient outcomes in various solid malignancies. This study aimed to evaluate the prognostic impact of PNI changes in patients with breast cancer undergoing neoadjuvant chemotherapy (NAC).

Methods

We reviewed patients with breast cancer who underwent NAC and a subsequent surgery for breast cancer between 2005 and 2016. PNI before and after NAC were calculated using the following formula: 10 × serum albumin (g/dl) + 0.005 × total lymphocyte count/mm3. The relationship between PNI and prognosis was retrospectively analyzed.

Results

In total, 191 patients were evaluated. There was no significant difference in disease-free survival (DFS) between the pre-NAC PNI high group and the pre-NAC PNI low group (cutoff: 53.1). However, PNI decreased in 181 patients (94.7%) after NAC and the mean PNI also significantly decreased after NAC from 52.6 ± 3.8 pre-NAC to 46.5 ± 4.4 post-NAC (p < 0.01) . The mean ΔPNI, which was calculated as pre-NAC PNI minus post-NAC PNI, was 5.4. The high ΔPNI group showed significantly poorer DFS than the low ΔPNI group (cut off: 5.26) (p = 0.015). Moreover, high ΔPNI was an independent risk factor of DFS on multivariate analysis (p = 0.025).

Conclusions

High decrease of PNI during NAC predicts poor prognosis. Thus, maintaining the nutritional status during NAC may result in better treatment outcomes in patients with breast cancer.
Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesis
Authors: Lu Tianyuan , Klein Kathleen Oros , Colmegna Inés , Lora Maximilien , Greenwood Celia M.T. , Hudson Marie 
Published: August 2019

Abstract
Background
Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease whose pathogenesis remains incompletely understood. Increasing evidence suggests that both genetic susceptibilities and changes in DNA methylation influence pivotal biological pathways and thereby contribute to the disease. The role of DNA methylation in SSc has not been fully elucidated, because existing investigations of DNA methylation predominantly focused on nucleotide CpGs within restricted genic regions, and were performed on samples containing mixed cell types.

Methods
We performed whole-genome bisulfite sequencing on purified CD4+ T lymphocytes from nine SSc patients and nine controls in a pilot study, and then profiled genome-wide cytosine methylation as well as genetic variations. We adopted robust statistical methods to identify differentially methylated genomic regions (DMRs). We then examined pathway enrichment associated with genes located in these DMRs. We also tested whether changes in CpG methylation were associated with adjacent genetic variation.

Results
We profiled DNA methylation at more than three million CpG dinucleotides genome-wide. We identified 599 DMRs associated with 340 genes, among which 54 genes exhibited further associations with adjacent genetic variation. We also found these genes were associated with pathways and functions that are known to be abnormal in SSc, including Wnt/-catenin signaling pathway, skin lesion formation and progression, and angiogenesis.

Conclusion
The CD4+ T cell DNA cytosine methylation landscape in SSc involves crucial genes in disease pathogenesis. Some of the methylation patterns are also associated with genetic variation. These findings provide essential foundations for future studies of epigenetic regulation and genome-epigenome interaction in SSc.
Antimicrobial activities and in vitro properties of cold-adapted Lactobacillus strains isolated from the intestinal tract of cold water fishes of high latitude water areas in Xinjiang, China
Authors: Wei Xiaojing , Zhang Yan , Zhou Hong , Tian Fengwei , Ni Yongqing 
Published: August 2019

Abstract
Background

There are still a large variety of microorganisms among aquatic animals, especially probiotic lactic acid bacteria in cold water fishes at high latitudes have not been fully developed. Hence, the present study aims to evaluate the probiotic potential of cold-adapted Lactobacillus strains isolated from the intestinal tract of cold water fishes (Xinjiang) and select candidates to be used as new food preservative agents and/or probiotic additives in feeding of aquaculture.

Results

A total of 43 Lactobacillus spp. were isolated from 16 kinds of intestinal tract of cold-water fishes. They were characterized by phenotypic methods, identified using rep-PCR and 16S rRNA gene sequencing as four species: Lactobacillus sakei (22 isolates), Lactobacillus plantarum (16 isolates), Lactobacillus casei (4 isolates) and Lactobacillus paracasei (1 isolate). The in vitro tests included survival in low pH and bile, antimicrobial activity (against Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica, Listeria monocytogenes, and Listeria innocua), resistance to 15 antibiotics and hemolytic tests. Among all 43 lactobacilli iaolates, the 22 isolates showed a wide range of antimicrobial activity against 6 different pathogenic strains. There were twenty isolates growing at a optimal temperature ranging 16~20°C, which were initially considered to be cold-adapted strains. Two (2) Lb. sakei strains and 2 Lb. plantarum strains demonstrated the highest survivability after 4 h of exposure at pH 2.0. Most of the tested strains cannot be cultrued after exposed into 0.5% bile solution for 4 h, while 2 Lb. plantarum strains (E-HLM-3, CQ-CGC-2) and 1 Lb. sakei strain M-DGM-2 survived even at 2% bile concentration. In addition, the safety assessment showed that 22 strains without any detectable hemolytic activity and resistant to glycopeptides (vancomycin, teicoplanin), levofloxacin, aztreonam, amikacin and oxacillin, while all the studied lactobacilli showed sensitivity to or semi-tolerant to other antibiotics.

Conclusions

In conclusion, based on all the experiments, 3 strains, including E-HLM-3, CQ-CGC-2, and M-DGM-2 might be a candidate of choice for using in the food preservative agents and/or probiotic additives in feeding of aquaculture.
Proteomic and transcriptomic analyses of early and late-chronic Toxoplasma gondii infection shows novel and stage specific transcripts
Authors: Garfoot Andrew , Wilson Gary , Coon Joshua , Knoll Laura 
Published: August 2019

Abstract
Background

The protozoan pathogen Toxoplasma gondii has the unique ability to develop a chronic infection in the brain of its host by transitioning from the fast growing tachyzoite morphology to latent bradyzoite morphology. A hallmark of the bradyzoite is the development of neuronal cysts that are resilient against host immune response and current therapeutics. The bradyzoite parasites within the cyst have a carbohydrate and protein-rich wall and a slow-replication cycle, allowing them to remain hidden from the host. The intracellular, encysted lifestyle of T. gondii has made them recalcitrant to molecular analysis in vivo.

Results

Here, we detail the results from transcriptional and proteomic analyses of bradyzoite-enriched fractions isolated from mouse brains infected with T. gondii over a time course of 21 to 150 days. The enrichment procedure afforded consistent identification over 2,000 parasitic peptides from the mixed-organism sample, representing 366 T. gondii proteins at 28, 90, and 120-day timepoints. Deep sequencing of transcripts expressed during these three timepoints revealed that a subpopulation of proteins is transcriptionally expressed at a high level: approximately one-third are more enriched during bradyzoite conditions compared to tachyzoites and approximately half are expressed at similar levels during each phase. The T. gondii transcript which increased the most over the course of chronic infection, sporoAMA1, shows stage specific isoform expression of the gene.

Conclusions

We have expanded the transcriptional profile of in vivo bradyzoites to 120 days post-infection and provided the first in vivo proteomic profile of T. gondii bradyzoites. The RNA sequencing depth of in vivo bradyzoite T. gondii was over 250-fold greater than previous reports and allowed us to identify low level transcripts and novel bradyzoite-specific isoforms.