bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Precipitation Estimation Using Convolutional Neural Network
Authors: Pan Baoxiang , Hsu Kuolin , AghaKouchak Amir , Sorooshian Soroosh 
Published: January 2019

AbstractPrecipitation process is generally considered to be poorly represented in numerical weather/climate models. Statistical downscaling (SD) methods, which relate precipitation with model resolved dynamics, often provide more accurate precipitation estimates compared to model's raw precipitation products. We introduce the convolutional neural network model to foster this aspect of SD for daily precipitation prediction. Specifically, we restrict the predictors to the variables that are directly resolved by discretizing the atmospheric dynamics equations. In this sense, our model works as an alternative to the existing precipitation‐related parameterization schemes for numerical precipitation estimation. We train the model to learn precipitation‐related dynamical features from the surrounding dynamical fields by optimizing a hierarchical set of spatial convolution kernels. We test the model at 14 geogrid points across the contiguous United States. Results show that provided with enough data, precipitation estimates from the convolutional neural network model outperform the reanalysis precipitation products, as well as SD products using linear regression, nearest neighbor, random forest, or fully connected deep neural network. Evaluation for the test set suggests that the improvements can be seamlessly transferred to numerical weather modeling for improving precipitation prediction. Based on the default network, we examine the impact of the network architectures on model performance. Also, we offer simple visualization and analyzing approaches to interpret the models and their results. Our study contributes to the following two aspects: First, we offer a novel approach to enhance numerical precipitation estimation; second, the proposed model provides important implications for improving precipitation‐related parameterization schemes using a data‐driven approach.
Synaptotagmin-7, a binding protein of P53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells
Authors: Fei Zhenhua , Gao Wei , Xie Raoying , Feng Ganzhu , Chen Xiaolin , Jiang Yiyan 
Published: January 2019

Abstract
Lung cancer has been one of the most common malignancies in the world. Cell senescence has been recognized as the avenue to inhibit tumor progression. However, the mechanisms remain poorly understood. In the present study, we have shown that synaptotagmin-7 (SYT7) expression was up-regulated in lung cancer. SYT7 also promoted the growth and colony formation of lung cancer cells and inhibited their senescence. In a molecular mechanism study, SYT7 was shown to interact with P53 and to potentiate the interaction between P53 and MDM2. Taken together, the present study demonstrates the oncogenic roles of SYT7 in lung cancer, and suggests that SYT7 may be a good therapeutic target for lung cancer treatment.
Hybrid interconnect network for on‐chip low‐power clock distribution
Authors: Ding Q. , Mak T. 
Published: January 2019

Clock is regarded as the heartbeat of modern synchronous digital integrated circuits. However, with the CMOS technology shrinking, it becomes critical to deliver high‐quality global clock signal with low propagation delay and hence conventional metallic interconnect seems to meet its bottleneck, as a clock distribution network (CDN) might consume up to 50% of the overall power. To address these problems, this Letter proposes a novel combination of wireless and conventional metallic interconnect to improve the performance of on‐chip clock distribution. By incorporating integrated wireless clock transceivers and efficient modulation technique, overall performance has been increased significantly with a total delay reduction of 66.8% compared with a new cornerstone tapered H‐tree model from 400 to 130 ps. In addition, clock uncertainties are now predictable according to the displacement of transceivers, 33 ps of clock skew at 2.5 GHz input with highly unbalanced loads could be found within the proposed CDN, and hence, indicates a promising potential of future high‐performance on‐chip clock distribution.
Forecasting photovoltaics/concentrated photovoltaics at national level – Portugal experience
Authors: Esteves Joao , Pastor Ricardo , Pinho da Silva Nuno , Pestana Rui , Chen Zhibao 
Published: January 2019

The solar power installed capacity all over the world is growing and this renewable energy technology is playing an important role to build a clean energy future. The solar forecast is a necessary tool for the transmission system operator in order to maintain the electricity network safety and reliability. This study aims to report the experience of R&D Nester in the solar forecast at national level in Portugal, forecasting for all solar plants connected to the very high voltage (400, 220 and 150 kV) and high voltage (60 kV) networks, providing this information to the Portuguese transmission system operator, REN. A novel approach to calculate cloud index from images from a sky camera is presented.
Temperature field simulation and ampacity optimisation of 500 kV HVDC cable
Authors: Zhou Boda , Le Yanjie , Fang Yalin , Yang Fan , Dai Tao , Sun Lu , Liu Jiapeng , Zou Lekai 
Published: January 2019

The temperature distribution of the submarine cable is an important parameter during the operation. In order to lift the efficiency of heat dissipation during the high‐voltage direct current (HVDC) cable thermal cycling test, this study presents a method of cooling the cable using a cooling pipe with circulating water. A three‐dimensional mode based on the thermal‐fluid coupled model was established for 500 kV HVDC submarine cable by using finite element simulation software COMSOL Multiphysics and Fluent. The temperature field distribution and carrying ampacity of the HVDC submarine cables were analysed and compared under two cooling modes including bipolar double pipe and bipolar single pipe. The results indicate that both cooling modes can lift the current carrying ampacity of the cable; the bipolar double tube cooling mode performs better in cooling, a tiny circulating water velocity can significantly reduce the temperature of the submarine cable. Thus both suitable cooling mode and circulating water velocity were determined to accelerate the heat dissipation of the submarine cable during the thermal cycling test.
Improved Ni II oscillator strengths from quasar absorption systems
Authors: Boissé P. , Bergeron J. 
Published: January 2019

Aims. We wish to improve the accuracy of oscillator strength values for several Ni II UV transitions and measure for the first time the f-value of a few other weak transitions for which no laboratory nor astronomical measurement is presently available.
Methods. Four quasars displaying five damped Lyman α systems with relatively strong Ni II lines were selected. From the analysis of the excellent high resolution spectra available, we determined the relative f-value of Ni II transitions by comparing the strength of the corresponding absorption profiles. To quantify the latter, we used the apparent optical depth method for resolved features, equivalent width measurements for optically thin lines and line fitting with VPFIT. Absolute f-values were then derived by relating our determinations to the available laboratory measurements.
Results. Thanks to the good signal-to-noise ratio of the spectra and to the suitable properties of the absorption systems investigated, we are able to significantly improve the determination of the f-value for 13 Ni II transitions falling in the 1317–1804 Å interval. Our results are found to be consistent with other earlier determinations for ten of these transitions; our median relative accuracy for these f-values is 6.5%. For three weak transitions near 1502, 1773, and 1804 Å, which have not been detected previously in astronomical spectra, we can get a first measurement of their f-value.
Conclusions. Our work illustrates that, thanks to the redshift and the absence of variations of physical constants on cosmological scales, the analysis of absorption lines induced by remote gas in quasar spectra can nowadays provide valuable constraints on atomic data in the UV range.
Theoretical investigation of energy levels and transition data for P II
Authors: Rynkun P. , Radžiūtė L. , Gaigalas G. , Jönsson P. 
Published: January 2019

Aims. The main goal of this paper is to present accurate and extensive transition data for the P II ion. These data are useful in various astrophysical applications.
Methods. The multiconfiguration Dirac–Hartree–Fock (MCDHF) and relativistic configuration interaction (RCI) methods, which are implemented in the general-purpose relativistic atomic structure package GRASP2K, were used in the present work. In the RCI calculations the transverse-photon (Breit) interaction, the vacuum polarization, and the self-energy corrections were included.
Results. Energy spectra are presented for 48 even states of the 3s23p2, 3s23p{4p, 4f, 5p, 5f, 6p}, 3s3p23d configurations, and for 58 odd states of the 3s3p3, 3s23p{3d, 4s, 4d, 5s, 5d, 6s} configurations in the P II ion. Electric dipole (E1) transition data are computed between these states along with the corresponding lifetimes. The average uncertainty of the computed transition energies is between five and ten times smaller than the uncertainties from previous calculations. The computed lifetimes for the 3s23p4s3Po states are within the error bars of the most current experimental values.
A systems engineering framework for the design of bioprocess operator training simulators
Authors: Isimite Joseph , Baganz Frank , Hass Volker 
Published: January 2019

Operator training simulators (OTS) are widely used in several industries including chemical processing, oil and gas, medicine, aircraft and nuclear facilities. However, developing a biorefinery OTS is a complex engineering design activity that requires a structured technique. This paper presents a structured methodology that applies design frameworks from other disciplines and a user-centred approach for biorefinery OTS design. These include the definition of end user requirements (operator training needs), and the analysis of these requirements using Quality Function Deployment (QFD). Furthermore, an algorithm for bioprocess optimisation and automatic adjustment of operating parameters is developed for integration into the OTS. This algorithm is based on the Nelder-Mead simplex method for multi-dimensional function minimisation.
Identified user requirements were categorized into primary, secondary and tertiary training needs, with increasing levels of detail from primary to tertiary needs. The relationships between identified operator training needs and OTS technical and functional specifications were investigated, and a priority rating assigned to the most important OTS specifications. Identified OTS specifications were evaluated for robustness to ensure that important features were not omitted from the final design.
Analysis of atmospheric attenuation using the Telescope Array central laser data
Authors: AbuZayyad Tareq 
Published: January 2019

Located in the western desert of the state of Utah, the Telescope Array (TA) experiment measures the properties of ultra high energy cosmic ray (UHECR) induced extensive air showers. TA employs a hybrid detector comprised of a large surface array of scintillator detectors overlooked by three fluorescence telescopes stations. The TA Low Energy extension (TALE) detector has operated as a monocular Cherenkov/fluorescence detector for nearly five years, and has recently been complemented by a closely spaced surface array to operate in hybrid mode. The TAx4 upgrade is underway and aims to, as the name suggests, quadruple the size of the surface array to improve statistics at the highest energies (post-GZK events).
The analysis of the TA fluorescence detectors (FD) data requires knowledge of the degree of the atmospheric attenuation of UV light produced by shower particles. This attenuation depends partially on the amount of aerosols present in the atmosphere at the time of shower observation. Being highly variable, real time measurement of the aerosols light attenuation is accomplished through the use of a central laser facility (CLF) located at the center of the surface array, and in the field of view of the three FDs, as well as, the TALE FD. In this proceeding we will describe the experiment, and the CLF data and analysis, and give results on measured aerosols attenuation, yearly averaged. FD measurements of shower energy and Xmax, involve corrections for atmospheric attenuation due to the presence of aerosols. We discuss the errors introduced into the shower parameters reconstruction due to uncertainty about aerosols attenuation.
Ground-Based Observations of Terrestrial Gamma Ray Flashes Associated with Downward-Directed Lightning Leaders
Authors: Abbasi Rasha , Belz John , Le Von Ryan , Rodeheffer Dan , Krehbiel Paul , Remington Jackson , Rison William 
Published: January 2019

Terrestrial gamma-ray flashes (TGFs) are bursts of gamma-rays initiated in the Earth’s atmosphere. TGFs were serendipitously first observed over twenty years ago by the BATSE gamma ray satellite experiment. Since then, several satellite experiments have shown that TGFs are produced in the upward negative breakdown stage at the start of intracloud lightning discharges. In this proceeding, we present ground-based observation of TGFs produced by downward negative breakdown occurring at the beginning of negative cloud-to-ground flashes.The Terrestrial gamma-ray flashes discussed in this work were detected between 2014-2017 at ground level by the Telescope Array surface detector (TASD) together with Lightning Mapping Array (LMA) and the slow electric field antenna (SA). The TASD detector is a 700 km2ultra high energy cosmic ray detector in the southwestern desert of Utah. It is comprised of 507 (3 m2) plastic scintillator detectors on a 1.2 km square grid. The LMA detector, a three-dimensional total lightning location system, is comprised of nine stations located within and around the array. The slow electric field antenna records the electric field change in lightning discharges.The observed Gamma ray showers were detected in the first 1-2 ms of downward negative breakdown prior to cloud-to-ground lightning strikes. The shower sources were observed by the LMA detector at altitudes of a few kilometers above ground level. The detected energetic burst showers have a footprint on the ground typically ~ 3-5 km in diameter. The bursts comprise of several (2-5) individual pulses, each of which have a span of a few to tens of microseconds and an overall duration of several hundred microseconds. Using a forward-beamed cone of half-angle of 16 degrees, GEANT simulation studies indicate that the showers are consistent with gamma rays of 1012- 1014primary photons. We hypothesize that the observed terrestrial gamma-ray flashes are similar to those detected by satellites, but that the ground-based observations are closer to the source and therefore are able to observe weaker sources and report on the structure of the temporal distribution at the source. This result and future studies will enable us to better identify and constrain the mechanisms of downward TGF production.
Apprendre a réaliser une radiographie a l’aide d’un simulateur numérique
Authors: Doidy Franck , Anne Jean-François 
Published: January 2019

Les outils numériques transforment les pratiques pédagogiques. En particulier, les simulateurs informatiques ont pris une place importante dans la formation des professionnels de santé. Ils sont devenus le support incontournable des cours magistraux.
Dans cette optique, nous avons développé un simulateur numérique d’imagerie radiologique de projection. Pour réaliser une radiographie, l’étudiant saisit, sur l’interface graphique, l’ensemble des paramètres nécessaires au fonctionnement d’un tube à rayons X. Il visualise immédiatement le cliché obtenu, en particulier les conséquences de l’utilisation de paramètres inadaptés.
Ce simulateur convivial et interactif place les étudiants dans une position active. Il est un outil indispensable pour la consolidation des enseignements magistraux ainsi que pour l’évaluation du savoir-faire et du savoir-être des étudiants.
Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos
Authors: Krishna Benjamin A. , Humby Monica S. , Miller William E. , O’Connor Christine M. 
Published: January 2019

SignificanceHuman cytomegalovirus (HCMV) is a widespread pathogen that remains with an individual for life in a quiescent/latent state, posing little threat to an otherwise healthy person. However, when an individual’s immune system is severely compromised, HCMV can reactivate to its active/lytic state, resulting in viral spread and disease that is often fatal. The biological mechanisms underlying HCMV latency and reactivation remain poorly understood. Herein we show that the viral-encoded G protein-coupled receptor (GPCR)US28aids in the establishment and the maintenance of viral latency. Furthermore, we find that US28 modulates host-cell proteins to suppress viral processes associated with active/lytic replication, thereby promoting latent infection. This work provides the mechanism by which HCMV modulates the host-cell environment to its advantage.
Combined impacts of prolonged drought and warming on plant size and foliar chemistry
Authors: Orians Colin M , Schweiger Rabea , Dukes Jeffrey S , Scott Eric R , Müller Caroline 
Published: January 2019

Abstract

Background and Aims
Future shifts in precipitation regimes and temperature are expected to affect plant traits dramatically. To date, many studies have explored the effects of acute stresses, but few have investigated the consequences of prolonged shifts in climatic conditions on plant growth and chemistry.

Methods
Plant size and metabolite profiles were assessed on naturally occurring Plantago lanceolata plants growing under different precipitation (ambient, 50 % less than ambient = drought) and temperature (ambient, +0.8, +2.4 and +4.0 °C above ambient) treatments at the Boston Area Climate Experiment (constructed in 2007).

Key Results
The analysis of primary and secondary metabolites revealed pronounced effects of drought, and a precipitation × temperature interaction. Strikingly, the effects of precipitation were minimal at the two lower temperatures but marked at the two higher temperatures. Compared with the ambient condition, plants in the drought plots had lower concentrations of foliar nitrogen, amino acids and most sugars, and higher concentrations of sorbitol, citrate and malate, common stress-induced metabolites. This pattern was especially evident at high temperatures. Moreover, drought-exposed plants showed lower concentrations of catalpol, an iridoid glycoside.

Conclusions
While the effect of warming on the metabolite profiles was less pronounced, differences were marked when combined with drought. Given the interactive effect of environmental variables on leaf chemistry, and the fact that woody and herbaceous plants seem to differ in their responses to temperature and precipitation, future studies should account for the direct and indirect effects of the community response to multifactorial field conditions.
METACLUSTER—an R package for context-specific expression analysis of metabolic gene clusters
Authors: Banf Michael , Zhao Kangmei , Rhee Seung Y 
Published: January 2019

Abstract

Summary
Plants and microbes produce numerous compounds to cope with their environments but the biosynthetic pathways for most of these compounds have yet to be elucidated. Some biosynthetic pathways are encoded by enzymes collocated in the chromosome. To facilitate a more comprehensive condition and tissue-specific expression analysis of metabolic gene clusters, we developed METACLUSTER, a probabilistic framework for characterizing metabolic gene clusters using context-specific gene expression information.

Availability and implementation
METACLUSTER is freely available at https://github.com/mbanf/METACLUSTER.

Supplementary information
Supplementary data are available at Bioinformatics online.
Glycocalyx Breakdown Is Associated With Severe Disease and Fatal Outcome in Plasmodium falciparum Malaria
Authors: Yeo Tsin W , Weinberg J Brice , Lampah Daniel A , Kenangalem Enny , Bush Peggy , Chen Youwei , Price Richard N , Young Sarah , Zhang Hao Y , Millington David , Granger Donald L , Anstey Nicholas M 
Published: January 2019

AbstractBackgroundInteractions between the endothelium and infected erythrocytes play a major role in the pathogenesis of falciparum malaria, with microvascular dysfunction and parasite sequestration associated with worsening outcomes. The glycocalyx is a carbohydrate-rich layer that lines the endothelium, with multiple roles in vascular homeostasis. The role of the glycocalyx in falciparum malaria and the association with disease severity has not been investigated.MethodsWe prospectively enrolled Indonesian inpatients (aged ≥18 years) with severe (SM) or moderately severe (MSM) falciparum malaria, as defined by World Health Organization criteria, and healthy controls (HCs). On enrollment, blood and urine samples were collected concurrently with measurements of vascular nitric oxide (NO) bioavailability. Urine was assayed for glycocalyx breakdown products (glycosaminoglycans) using a dimethylmethylene blue (GAG-DMMB) and liquid chromatography-tandem mass spectrometry (GAG-MS) assay.ResultsA total of 129 patients (SM = 43, MSM = 57, HC=29) were recruited. GAG-DMMB and GAG-MS (g/mol creatinine) were increased in SM (mean, 95% confidence interval: 3.98, 2.44–5.53 and 6.82, 5.19–8.44) compared to MSM patients (1.78, 1.27–2.29 and 4.87, 4.27–5.46) and HCs (0.22, 0.06–0.37 and 1.24, 0.89–1.59; P &lt; 0.001). In SM patients, GAG-DMMB and GAG-MS were increased in those with a fatal outcome (n = 3; median, interquartile range: 6.72, 3.80–27.87 and 12.15, 7.88–17.20) compared to survivors (n = 39; 3.10, 0.46–4.5 and 4.64, 2.02–15.20; P = 0.03). Glycocalyx degradation was significantly associated with parasite biomass in both MSM (r = 0.48, GAG-DMMB and r = 0.43, GAG-MS; P &lt; 0.001) and SM patients (r = 0.47, P = 0.002 and r = 0.33, P = 0.04) and inversely associated with endothelial NO bioavailability.ConclusionsIncreased endothelial glycocalyx breakdown is associated with severe disease and a fatal outcome in adults with falciparum malaria.