bluuebunny/crossref_metadata_2025_split huggingface dataset:
State of the Art and Recent Developments of Radiopharmaceuticals for Pancreatic Neuroendocrine Tumors Imaging
Authors: Carollo Angela , Papi Stefano , Grana Chiara M. , Mansi Luigi , Chinol Marco 
Published: March 2019

Background:Neuroendocrine Tumors (NETs) are relatively rare tumors, mainly originating from the digestive system, that tend to grow slowly and are often diagnosed when metastasised. Surgery is the sole curative option but is feasible only in a minority of patients. Among them, pancreatic neuroendocrine tumors (pancreatic NETs or pNETs) account for less than 5% of all pancreatic tumors. Viable therapeutic options include medical treatments such as biotherapies and more recently Peptide Receptor Radionuclide Therapies (PRRT) with radiolabeled somatostatin analogues. Molecular imaging, with main reference to PET/CT, has a major role in patients with pNETs.Objective:The overexpression of specific membrane receptors, as well as the ability of cells to take up amine precursors in NET, have been exploited for the development of specific targeting imaging agents.Methods:SPECT/CT and PET/CT with specific isotopes such as [68Ga]-1,4,7,10-tetra-azacyclododecane- N,N’,N’’,N’’’-tetra-acetic acid (DOTA)-somatostatin analogs, [18F]-FDG and [18F]-fluorodopa have been clinically explored.Results:To overcome the limitations of SSTR imaging, interesting improvements are connected with the availability of new radiotracers, activating with different mechanisms compared to somatostatin analogues, such as glucagon-like peptide 1 receptor (GLP-1 R) agonists or antagonists.Conclusion:This paper shows an overview of the RPs used so far in the imaging of pNETs with insight on potential new radiopharmaceuticals currently under clinical evaluation.
Obesidad en adolescentes y criterios para el desarrollo de síndrome metabólico
Authors: Ávila-Alpirez H. , Gutiérrez-Sánchez G. , Guerra-Ordoñez J. , Ruíz-Cerino J. , Martínez-Aguilar M. 
Published: March 2019

Objetivo: El objetivo de este trabajo es determinar los criterios para síndrome metabólico (SM) de mayor influencia en adolescentes con obesidad.
Método: El estudio fue de tipo descriptivo y transversal, la muestra la conformaron 122 adolescentes de nivel preparatoria, seleccionados por un muestreo aleatorio simple. Se realizó somatometría (peso, talla y circunferencia de cintura), así como medición de la presión arterial y toma de muestra sanguínea.
Resultados: Predominó la obesidad grado I (68%), el principal criterio para el diagnóstico de síndrome metabólico fue la obesidad abdominal en el 98.4% de los participantes; el 25.4% de estos presentaron tres o más criterios alterados por lo que se consideran con SM, además se encontró asociación entre los niveles de glicemia con la obesidad (p< 0.01).
Conclusiones: Los hallazgos de esta investigación mostraron elevada prevalencia de SM en los participantes. La obesidad abdominal es un claro signo de problemas relacionados con el peso y se presenta muy frecuentemente en la población joven con obesidad. La adolescencia es una etapa temprana para educar a las personas y fomentar una vida más sana que permita mantenerlos lejos del desarrollo de enfermedades crónico degenerativas.
Validación del instrumento: Competencias del personal de enfermería en Salud Pública, en el contexto mexicano
Authors: Castañeda-Hidalgo H. , Vega-Infante E. , González F. , Rangel S. , Flores F. , Peñarrieta-de Cordova I. 
Published: March 2019

Introducción: Cuando se utilicen cuestionarios desarrollados en otros países e idiomas en estudios científicos, además de traducirlos, es necesario su adaptación cultural y validación, el objetivo de esta investigación es contar con un instrumento válido y confiable para evaluar las competencias del personal de enfermería en salud pública, para aplicarlo en el contexto mexicano.
Metodología: El estudio fue de tipo descriptivo-transversal, multietápico, la población se integró en 3 grupos para las 3 diferentes etapas, en la primera, por un grupo de 10 expertos en investigación de la Facultad de Enfermería de Tampico, de la Universidad Autónoma de Tamaulipas, México y 17 profesionales que laboran en el primer nivel de atención; en la segunda, 30 profesionales de enfermería y en la tercera 177 profesionales que trabajan en el campo de la salud pública, todos ellos de tres jurisdicciones del Sur de Tamaulipas, México, el muestreo fue por conveniencia.
Resultados: En cuanto a los tres procesos que se realizaron para la validación del instrumento, se mostraron resultados adecuados y satisfactorios para su aplicación, ya que en la prueba de V-Aiken se obtuvo un resultado cercano a 1, en el proceso semántico sólo se realizó modificación a una palabra; a través de la prueba piloto se obtuvo un resultado de 0.97 en el alfa de cronbach.
Conclusiones: El instrumento se considera válido para iniciar con la evaluación de las mencionadas competencias, para contar con un diagnóstico inicial de las áreas de oportunidad para personal de enfermería.
Cuidado especializado a neonato prematuro fundamentado en la teoría general del autocuidado
Authors: Sánchez-Quiroz F. , Álvarez-Gallardo L. 
Published: March 2019

Introducción: Los nacimientos prematuros permanecen como un problema perinatal, afectan entre 5 y 12% de los nacimientos, la principal condición clínica asociada a estos es el Síndrome de Dificultad Respiratoria (SDR), inicia inmediatamente al nacimiento con dificultad respiratoria progresiva que requiere asistencia ventilatoria e ingreso a Unidades de Cuidados Intensivos Neonatales (UCIN). Se presenta el abordaje de manera integral a una recién nacida de 32 SDG con SDR, en un hospital de segundo nivel de atención, en este se aplicó el proceso enfermero.
Objetivo: Brindar atención integral e individualizada con cuidados específicos al neonato prematuro, con base en la Teoría General del Autocuidado.
Método: Selección de paciente a conveniencia en UCIN, aplicación de la metodología del proceso enfermero, valoración basada en los requisitos universales de autocuidado. La información obtenida fue a través del expediente clínico, entrevista a la madre y valoración de la recién nacida. Se analizaron los datos, se emitieron diagnósticos enfermeros, se ejecutó plan de cuidados fundamentados por artículos científicos y guías de práctica clínica.
Resultados: Se realizaron 12 diagnósticos de enfermería, 10 reales y 2 de riesgo de acuerdo con los requisitos de autocuidado universal, se identificaron los más alterados: mantenimiento de un aporte suficiente de aire, agua y alimentos, y provisión de cuidados asociados con los procesos de excreción.
Conclusiones: Se lograron intervenciones independientes e interdependientes; sin embargo, el neonato permaneció en UCIN debido a que su atención es compleja y requiere personal capacitado con conocimientos y habilidades fundamentadas para el cuidado. La asistencia al prematuro debe ser inmediata para la detección precoz y manejo de patologías frecuentes.
Should Off-Label Medicines Be Included In The Universal Health Coverage (UHC) Schemes? Why, When, and How?
Authors: Mulyani Ully Adhie 
Published: March 2019

Abstract
Off label medicine refers to any medicine that is used to treat any ailment beyond of its approved / licensed indication by National Regulatory Authorities, such us FDA in USA and BPOM in Indonesia. Off-label medicines are used because the available and approved drugs do not have the desired effect, then doctors try medicine that have not been licensed indications. Some other reasons in practice off-label medicines use and prescribing are that drugs in the same category have the same effect (although have not been approved by indication), the expansion to a lighter form than the licensed indication, or extension of use for certain related conditions. At the opposite, the disadvantage of the practice off-label medicine use is generally not included in any health insurance benefit package, also not covered by mandatory insurance scheme (JKN-BPJS). Patients should pay for the price of a drug that has not been assured or proven of its efficacy and safety. It needs strong evidence based on scientific research to ensure the safety and effectiveness of off-label medicines to be included in the list of medications (national formulary) to put it on National Health Insurance (BPJS) benefit package.
Abstrak
Obat off-label adalah obat yang digunakan di luar indikasi yang disetujui oleh lembaga yang berwenang, kalau di Amerika Food and Drug Administration (FDA), sedangkan di Indonesia Badan POM. Obat off label digunakan karena obat yang tersedia dan approved tidak memberikan efek yang diinginkan, sehingga dokter mencoba obat yang belum disetujui indikasinya. Beberapa alasan lain adalah adanya dugaan bahwa obat dari golongan yang sama memiliki efek yang sama (walaupun belum disetujui indikasinya), adanya perluasan ke bentuk yang lebih ringan dari indikasi yang disetujui, atau perluasan pemakaian untuk kondisi tertentu yang masih terkait. Kerugiannya adalah obat off-label umumnya tidak dicover oleh BPJS sehingga pasien harus membayar sendiri harga obat yang belum terjamin efikasi dan keamanannya. Perlu dukungan penelitian yang kuat terhadap keamanan dan efektivitas obat off label agar dapat dimasukkan dalam daftar obat (formularium nasional) yang ditanggung BPJS.
Metode Systematic Literature Review untuk Identifikasi Platform dan Metode Pengembangan Sistem Informasi di Indonesia
Authors: Triandini Evi , Jayanatha Sadu , Indrawan Arie , Werla Putra Ganda , Iswara Bayu 
Published: March 2019

Sistem informasi adalah cara-cara yang diorganisasi untuk mengumpulkan, memasukkan, mengolah, dan menyimpan data, serta untuk menyimpan, mengelola, mengendalikan, dan melaporkan informasi sedemikian rupa sehingga sebuah organisasi dapat mencapai tujuan yang telah ditetapkan. Pengembangan sistem informasi memiliki metode-metode yang beragam. Metode yang dapat digunakan untuk pengembangan sistem antara lain metode terstruktur dan berorientasi objek. Berdasarkan metode tersebut, suatu sistem akan dikembangkan untuk dapat dijalankan pada platform berbasis web, mobile, atau desktop. Saat ini belum diketahui berapa banyak sistem informasi yang dikembangkan oleh kedua metode tersebut, demikian juga belum diketahui juga berapa banyak aplikasi yang dijalankan oleh ketiga platform tersebut. Penelitian ini bertujuan untuk mengidentifikasi platform dan metode pengembangan sistem informasi di Indonesia yang datanya diperoleh dari jurnal yang terkait pada tahun 2013–2018. Metode yang digunakan dalam penelitian ini adalah Metode Systematic Literature Review (SLR). Metode SLR digunakan untuk mengidentifikasi, mengkaji, mengevaluasi, dan menafsirkan semua penelitian yang tersedia dengan bidang topik fenomena yang menarik, dengan pertanyaan penelitian tertentu yang relevan. Dengan penggunaan Metode SLR dapat dilakukan review dan identifikasi jurnal secara sistematis, yang pada setiap prosesnya mengikuti langkah-langkah atau protokol yang telah ditetapkan. Hasil penelitian menunjukkan bahwa platform yang dominan digunakan dalam pengembangan sistem informasi adalah berbasis website sedangkan metode dominan digunakan dalam menyelesaikan pengembangan sistem informasi adalah metode terstruktur.
The Effect of Geographic Constraints on the Academic Achievement of Students at King Saud University Using GIS Techniques: A Case Study
Authors: Qoradi Mofareh 
Published: March 2019

This research studied the effect geographic constraints of students' daily journey to King Saud University (KSU) on their learning achievement, their participation in extracurricular activities, and their visit of the university library. The data was collected from a random sample of KSU students that consisted of 854 students via an online survey during the academic year 2016. The technologies of geographic information systems have been employed to build a spatial model to measure the distance and taken time for the daily student drive from their houses to the university. 30% of the students’ houses are at a 20 km distance from KSU, 35% of the students need about 40 minutes to arrive at the university, and 8% who need about one hour to arrive. Since Riyadh is urbanized, high in population density, and has a lot of traffic, theses distances and time students spend in their daily drives to the university are causing stress and exhaustion and affect students' academic achievement. 68.42% of students indicated that the location of their homes affects their learning achievement and 63.95% answered that it affects their attendance of activities in the university. Regarding visiting the library, about 58.16 responded that location of their homes affects library visits. The study clarified that there is a negative correlation between the students’ delay times and their academic rate, in other words as the delay times increase, students GPAs decline and subsequently, their academic achievement is less. Finally, the study suggested to specifying and rescheduling the work times for employees and students in Riyadh to reduce the daily drive times, the environmental pollution, and economic depreciation and help increase students' academic achievement by delaying the official working hours for Higher Education institutions by an hour; to start at 9.00 a.m. instead 8.00 a.m. as is currently the case.
The Effectiveness of a Proposed Program based on TRIZ’s Theory (Innovative Solutions to Problems) in Treating Sixth-Grade Students’ Reading Difficulties
Authors: Al-Ahwal Ahmed S. 
Published: March 2019

The aim of the study was to prepare a program based on some of the principles of TRIZ (Innovative Solutions to Problems) to overcome some of the difficulties encountered by sixth-grade students. The study tools included a list of reading difficulties on two levels: identification and comprehension, the proposed program, teacher of the program application of the program, and the reading-test measuring the effectiveness of the proposed program. Seventy male and female sixth-grade students were randomly divided in two groups: experimental and control. The study confirmed the effectiveness of the proposed program in treating some reading difficulties. In addition, the students' reading showed a statistically significant difference at (0.05). These differences have been established in the direction of the group and its relevance.
Community of Monogenea in populations of Cichla monoculus from two tributaries of the Amazon River in the Northern Brazil
Authors: Oliveira M. S. B. , Adriano E. Aparecido , Tavares-Dias M. , Corrêa L. Lima 
Published: March 2019

Summary
This study compared the monogeneans community in C. monoculus from the Tapajós River (state of Pará) and Jari River (state of Amapá), northern Brazil. A total of 2188 monogeneans belonging to eight taxa were collected from the gills of fish: Gussevia arilla, Gussevia longihaptor, Gussevia tucunarense, Gussevia undulata, Sciadicleithrum ergensi, Sciadicleithrum umbilicum, Sciadicleithrum uncinatum and Tucunarella cichlae. Gussevia arilla was the dominant species for C. monoculus from the Tapajós River basin, while S. umbilicum predominated among the hosts from the Jari River basin. For the two populations of C. monoculus, the prevalence, mean intensity and mean abundance of monogeneans were different and the of parasites community had a high qualitative similarity (87.5 %). The monogeneans community of C. monoculus was characterized by high species richness, with infection values varying from low to moderate. The geographic distance and differences in environmental characteristics arising from the same did not influence the richness of species of monogeneans infesting C. monoculus in the Tapajós and Jari rivers, but appear to have been determinants in the differences observed in the structure of the monogenean communities in each region.
Digitaler Stil
Authors: Carpo Mario 
Published: March 2019

"In der Architektur kamen digitale Werkzeuge bereits frühzeitig zur Anwendung. Seit den frühen 1990er Jahren bereiteten digitale Entwurfstheorien dem digital turn den Weg und nahmen ihn oftmals vorweg. Im Mainstream angekommen, scheinen digitale Technologien nun einen neuen und umfassenden Stil der digitalen Fabrikation zu fördern – allerdings keinen, den die Architekten im Sinn hatten und keinen, der allen Architekten gefallen dürfte. </br></br>In architecture digital tools began to be used relatively early. Since the early 1990s, theories of digital sketching prepared the way for the and even anticipated it in some cases. Having moved mainstream, the most recent digital technologies seem to foster a new and comprehensive style of digital fabrication – albeit none that the architects would have had in mind, nor one that would please all architects.
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Pesan Nonverbal dalam Komunikasi Politik Wahidin Halim Sebagai Calon Gubernur Banten pada Pilkada Banten 2017
Authors: Santi Fitria 
Published: March 2019

ABSTRAKPenelitian ini bertujuan untuk mengetahui pesan nonverbal dalam komunikasi politik Wahidin Halim pada Pilkada Banten 2017, dan difokuskan hanya kepada pesan kinesik, proksemik, artifaktual, dan paralingustik. Pendekatan yang digunakan dalam penelitian ini adalah kualitatif dengan metode deskriptif. Teknik pengumpulan data menggunakan wawancara mendalam dan observasi nonpartisipan sebagai sumber data primer, dengan studi pustaka dan dokumentasi sebagai sumber sekunder. Hasil penelitian menunjukkan bahwa Wahidin Halim selalu tersenyum (pesan fasial) ketika sedang berhadapan dengan masyarakat Banten, sementara gerak olah tangannya (hand gesture) lebih sering terlihat mengangkat tangan dengan jari terbuka. Ketika berada di tengah masyarakat, jarak yang yang terbangun antara Wahidin Halim dengan masyarakat Banten tergolong jarak intim dan personal, sementara penampilan (pesan artifaktual) yang merupakan ciri khasnya ialah baju koko putih, celana hitam, dan peci hitam. Adapun dalam hal kecepatan bicara tergolong cepat, dengan intonasi suara bersemangat serta gaya komunikasi yang ceplas-ceplos dan humoris. Kata Kunci: Komunikasi politik, pesan nonverbal, Pilkada Banten 2017, Wahidin Halim ABSTRACTThis study aims to find out various nonverbal messages in Wahidin Halim's political communication in 2017 Banten elections, and focused only on the message of kinesik, proxemik, artifactual, and paralingustik. The approach used in this study is qualitative with descriptive method. The data collection techniques used in-depth interview and nonparticipant observation as primary data sources, with literature study and documentation as secondary sources. The results of this study showed that Wahidin Halim always smiled (facial message) when he was meeting the people of Banten, while the hand gesture was more often seen raising his hand with his fingers open. During the campaign, the distance between Wahidin Halim and the people of Banten was classified as intimate and personal. Meanwhile, the appearance (artifactual message) which is his trademark is white koko, black pants and peci hitam. As for the speed of speaking, Wahidin Halim is quite fast, enthusiasm in tone, and the communication style is ceplas-ceplos and humorous. Keywords: Political communication, nonverbal message, Banten Elections 2017, Wahidin Halim
Síndrome del Ojo Seco
Authors: Oviedo Nelson , Moya Ramírez Rodrigo Emilia 
Published: March 2019

Introducción: El síndrome del ojo seco, se entiende como un trastorno de la superficie ocular, cuyos síntomas esenciales son molestias en los ojos, alteración de la visión, inestabilidad de la película lagrimal, inflamación de la superficie ocular y destrucción de la misma en casos más severos; afecta la calidad de vida de los pacientes y es una de las enfermedades prevalentes en el mundo actual.
Objetivo: Realizar una revisión sistemática y crítica de la literatura sobre el Síndrome de Ojo Seco.
Material y Métodos: Se efectuó una revisión sistemática y crítica de la literatura durante el periodo 2014-2018, usando motores de búsqueda de artículos indexados en Scopus, Latindex, Scielo, PUBMED, MEDLINE, EMBASE, COCHRANE, sobre el tema Síndrome de Ojo Seco.
Resultados: La revisión sistemática de la Literatura en el periodo 2014-2018 permitió analizar 22 artículos publicados en revistas indexadas sobre el tema Síndrome de Ojo Seco, evidenciándose su conceptualización, prevalencia, factores de riesgo, etiopatogenia, manifestaciones clínicas, diagnóstico y tratamiento.
Conclusiones: El Síndrome del Ojo Seco es una enfermedad multifactorial, compleja y crónica, que afecta la superficie ocular debido a la deficiencia en la producción de lágrimas, mala calidad de estas o excesiva evaporación y que incide significativamente en la calidad de vida de los pacientes.
Prevalence of work-related musculoskeletal disorders in agricultural farmers of Bhaktapur District, Nepal
Authors: Mahto Prakash Kumar , Bhupal Gautam B.P.T. 
Published: March 2019

Background: Work-related musculoskeletal disorders are present in a range of occupations. This is confirmed from a number of studies done around the world. However, few attempts have been done to document the presence of musculoskeletal disorders in occupational diseases in Nepal and there are hardly any studies done to see musculoskeletal disorders in farmers of Nepal. Nepal is an agricultural country and traditional practices in farming are adopted demanding a lot on the manual work.
Objectives: Aim of this study is to find out the prevalence of musculoskeletal disorders in Bhaktapur district of Nepal.
Methods: This is a descriptive cross-sectional study design. A convenience sample of 246 farmers from Bhaktapur district, Nepal aged between 24-65 years, were included in the study. The Nordic musculoskeletal questionnaire was a tool adapted to measure MSDs in the farmers. Descriptive analysis of data was done.
Results: Farmers (n=246) reported pain in all the nine areas of the body mentioned in the questionnaire. More than 70% of farmers have some kind of musculoskeletal disorders. However, six major areas of pain were identified as: Neck-31(12.6 %), Shoulder-26(10.6%), Elbow- 30(12.2%), Low back- 89(36.2%), Knee- 53(21.5%) and ankle 32(13%).
Conclusion: The prevalence of musculoskeletal disorders in farmers is very high. Lack of awareness about the MSDs and improper knowledge of ergonomics causes the problems.
Synthesis and study of structural, morphological, optical and toxicological properties of ferromagnetic cobalt oxide nanoparticles in liver carcinoma cell line
Authors: Iqbal Seemab , Fakhar-e-Alam Muhammad , Amin N. , Ismail M. , Mustafa G. , Raza Ahmad M. , Atif M. 
Published: March 2019

AbstractCobalt-based nanoparticles are promising candidates towards countless biomedical applications due to their unique characteristics. Co3O4 nanoparticles were synthesized by applying the sol-gel technique and finally sintered at various temperatures (700, 800, 900 °C). The crystal size, morphology, purity, and optical properties were determined using a variety of advanced characterization techniques. To investigate photodynamic therapy feasibility by using Co3O4 nanoparticles in the liver cells, in-vitro cancerous liver cells (HepG2 cells) were exposed to light of wavelength 655 nm (red light) for 30 min at 50 mW cm−2 and in dark as well. After assessment of cell viability analysis, it is concluded that light-induced photodynamic therapy shows significant phototoxic effects based on temperature dependency.