bluuebunny/crossref_metadata_2025_split huggingface dataset:
XIV.—The Muscular and Reproductive Systems ofAtomaria ruficornis(Marsham) (Coleoptera, Cryptophagidæ.)
Authors: Evans M. E. G. 
Published: June 2019

SynopsisThis is a study of the functional morphology of the muscular and reproductive systems of the adult beetle,Atomaria ruficornis(Marsham) made by means of serial sections and dissections. An account is given of the skeleto-muscular system of the head, thorax and abdomen with reference to previous work in this sphere. Wherever possible, the muscles described have been homologized with those of other Coleoptera. In a small number of cases, it has been found necessary to use new names for muscles. The probable mode of action of the mouth-parts and foregut during feeding is described. An account is given of the reproductive organs and genitalia of both male and female beetles; the muscular system of the genitalia in both sexes is described fully, and the functioning of the genitalia is discussed.
XVIII.—Tristichia ovensigen. et sp. nov., a Protostelic Lower Carboniferous Pteridosperm from Berwickshire and East Lothian, with an Account of some Associated Seeds and Cupules
Authors: Long Albert G. 
Published: June 2019

SynopsisTristichia ovensiis a Lower Carboniferous Pteridosperm known from both petrifactions and compressions. The stems possess a triradiate protostele and some show secondary xylem. The petioles have a butterfly-shaped trace and dichotomize repeatedly forming very slender axes sometimes bearing minute terminal pinnules similar to those ofMoresnetia zalesshyiStockmans. Associated withTristichiaare seeds and cupules ofStamnostoma huttonenseand less frequently compressions of seeds borne terminally on very fine dichotomous pedicels.
Economic Factors
Authors: Whitaker Arthur P. 
Published: June 2019

I was invited to prepare an interpretative essay on this subject. That, and nothing more, is what this paper aspires to be. It is not a monograph and any resemblance it may bear to historiography or bibliography is purely coincidental.Any essay on economic factors in the Latin American independence movement labors under a heavy heuristic handicap. The difficulty begins with the paucity of basic economic studies of the period. This deficiency was noted by Charles Griffin ten years ago in a related paper; little progress towards filling the gap has been made since.In so far as it is possible to identify and evaluate the economic factors in the independence movement, they appear less important than the political and perhaps other factors. This is almost certainly so if the question is one of conscious motivation, and probably so whatever the terms of the question.
Research Development on Sustainable Urban Infrastructure From 1991 to 2017: A Bibliometric Analysis to Inform Future Innovations
Authors: Du Huibin , Liu Diyi , Lu Zhongming , Crittenden John , Mao Guozhu , Wang Shuai , Zou Hongyang 
Published: June 2019

AbstractStudies of sustainable urban infrastructure are expanding since the United Nations proposed the concept of sustainability in 1982. The need for more sustainable urban infrastructures led to many research efforts on innovative technologies and development strategies. We analyzed research progress on sustainable urban infrastructure from 1991 to 2017 using bibliometric, keyword co‐occurrence and document cocitation network analysis. An increasing publication number suggests a rapid development of the sustainable urban infrastructure research area, but the development is still in an emerging stage. With respect to the analysis of research themes, we analyzed keyword co‐occurrence networks in the three stages of 1991‐1999, 2000‐2008, and 2009‐2017. We observed substantial expansions and intensive interconnections of research theme clusters on sustainable urban infrastructure. The themes from 2009 to 2017 include “critical infrastructure,” “urban planning and design,” “development need,” “technology innovation,” and “cyber‐physical system.” The United States produced 28.93% of the publications and played a core role in the international collaboration network. We further compared national interests among top productive countries, which highlights different priorities of investing more sustainable urban infrastructures. Finally, we presented an in‐depth analysis of four emerging technology innovations, namely, renewable energy, smart grid, green infrastructure, and cloud computing regarding research directions and challenges. Our results not only provide a valuable reference for researchers who are interested in sustainable urban infrastructures but also put forward the emphasis and orientations of future studies.
Comparison of Environmental and Mesoscale Characteristics of Two Types of Mountain‐to‐Plain Precipitation Systems in the Beijing Region, China
Authors: Xiao Xian , Sun Juanzhen , Chen Mingxuan , Qie Xiushu , Ying Zhuming , Wang Yingchun , Ji Lei 
Published: June 2019

AbstractBeijing, China, is located in a region of complex terrain with high mountain ridges to the northwest and the Bohai Sea to the southeast. The origin of convective storms occurring on the plains can often be traced to the upstream mountains. Under weakly forced conditions, these convective storms most frequently evolve into squall lines (SL) and convective clusters (CC) when reaching the plains. In this study, we analyze 18 SL and 15 CC storm systems and assess their environmental and mesoscale differences between the two phenomena. By analyzing the frequency of convective occurrence for the two types of storms based on composite radar reflectivity, it is found that the high frequencies are located in the south of Beijing for SL and near the center of Beijing for CC. Using storm‐scale reanalysis data produced by a rapid update four‐dimensional variational analysis system that assimilates Doppler radar observations, distinct features of the SL and CC storms are revealed in terms of their convective environments and mesoscale structures, such as cold pool, horizontal wind convergence, and humidity distribution. It is found that low convective inhibition and high low‐level wind speed on the plains are common to both SL and CC, whereas higher vertical shear over the plains and stronger wind speed on both mountains and plains distinguishes SL from CC. We further show that the stronger wind and vertical shear in SL generate stronger and more organized downdrafts, producing a deeper cold pool, strong outflow and convergence, which explains the formation of the high‐frequency center in the south of Beijing. In contrast, the cold pool produced in CC is shallower and weaker, resulting in weaker outflow and convergence and convective activities that are located only in central Beijing.
Modeling Study of the Air Quality Impact of Record‐Breaking Southern California Wildfires in December 2017
Authors: Shi Hongrong , Jiang Zhe , Zhao Bin , Li Zhijin , Chen Yang , Gu Yu , Jiang Jonathan H. , Lee Meemong , Liou Kuo‐Nan , Neu Jessica L. , Payne Vivienne H. , Su Hui , Wang Yuan , Witek Marcin , Worden John 
Published: June 2019

AbstractWe investigate the air quality impact of record‐breaking wildfires in Southern California during 5–18 December 2017 using the Weather Research and Forecasting model with Chemistry in combination with satellite and surface observations. This wildfire event was driven by dry and strong offshore Santa Ana winds, which played a critical role in fire formation and air pollutant transport. By utilizing fire emissions derived from the high‐resolution (375 × 375 m2) Visible Infrared Imaging Radiometer Suite active fire detections, the simulated magnitude and temporal evolution of fine particulate matter (PM2.5) concentrations agree reasonably well with surface observations (normalized mean bias = 4.0%). Meanwhile, the model could generally capture the spatial pattern of aerosol optical depth from satellite observations. Sensitivity tests reveal that using a high spatial resolution for fire emissions and a reasonable treatment of plume rise (a fair split between emissions injected at surface and those lifted to upper levels) is important for achieving decent PM2.5 simulation results. Biases in PM2.5 simulation are relatively large (about 50%) during the period with the strongest Santa Ana wind, due to a possible underestimation of burning area and uncertainty in wind field variation. The 2017 December fire event increases the 14‐day averaged PM2.5 concentrations by up to 231.2 μg/m3 over the downwind regions, which substantially exceeds the U.S. air quality standards, potentially leading to adverse health impacts. The human exposure to fire‐induced PM2.5 accounts for 14–42% of the annual total PM2.5 exposure in areas impacted by the fire plumes.
A Multiscale Study on Shale Wettability: Spontaneous Imbibition Versus Contact Angle
Authors: Siddiqui Mohammed Abdul Qadeer , Chen Xiao , Iglauer Stefan , Roshan Hamid 
Published: June 2019

AbstractEnvironmental and technical issues associated with hydraulic fracturing fluid leak‐off and its low recovery in clay‐rich shale reservoirs has challenged the energy sector. One of the main hypothesized mechanisms for the uptake of fracturing fluid is fluid imbibition due to capillary forces that are a strong function of the rock's wettability. However, shale wettability estimated by contact angle and spontaneous imbibition experiments are highly inconsistent throughout the literature. It is therefore critical to shed light on the possible reasons for such discrepancies and identify the superior technique. In order to characterize the physical processes from microscale to macroscale, the contact angles and spontaneous imbibition characteristics of shale samples were measured using aqueous ionic solutions (NaCl, KCl, CaCl2, and MgCl2) at different concentrations (0, 0.1, and 0.5 M) and oil (Soltrol‐130). The internal structure of the samples exposed to deionized water was imaged by three‐dimensional X‐ray micro‐computed tomography before and after spontaneous imbibition at both unconfined and confined stress states. Additionally, the structure of all samples exposed to each ionic solution was analyzed via environmental scanning electron microscopy. Experimental observations were further substantiated by combining digital image correlation with Poisson‐Boltzmann analysis to assess the hydration‐induced strains. It was shown that while spontaneous imbibition is a more realistic measurement for liquids, results obtained under unconfined condition can be highly biased due to additional forces acting (e.g., osmotic or hydration forces) and also potential microstructural alterations. Thus, spontaneous imbibition measured under reservoir stress condition is strongly recommended for shale wettability estimation.
Socioeconomic inequalities in childhood-to-adulthood BMI tracking in three British birth cohorts
Authors: Norris Tom , Bann David , Hardy Rebecca , Johnson William 
Published: June 2019

AbstractBackgroundBody mass index (BMI) tracks from childhood-to-adulthood, but the extent to which this relationship varies across the distribution and according to socio-economic position (SEP) is unknown. We aimed to address this using data from three British cohort studies.MethodsWe used data from: 1946 National Survey of Health and Development (NSHD,n = 2470); 1958 National Child Development Study (NCDS,n = 7747); 1970 British Cohort Study (BCS,n = 5323). BMI tracking between 11 and 42 years was estimated using quantile regression, with estimates reflecting correlation coefficients. SEP disparities in tracking were investigated using a derived SEP variable based on parental education reported in childhood. This SEP variable was then interacted with the 11-year BMI z-score.ResultsIn each cohort and sex, tracking was stronger at the upper end of the distribution of BMI at 42 years. For example, for men in the 1946 NSHD, the tracking estimate at the 10th quantile was 0.31 (0.20, 0.41), increasing to 0.71 (0.61, 0.82) at the 90th quantile. We observed no strong evidence of SEP inequalities in tracking in men in the 1946 and 1958 cohorts. In the 1970 cohort, however, we observed tentative evidence of stronger tracking in low SEP groups, particularly in women and at the higher end of the BMI distribution. For example, women in the 1970 cohort from low SEP backgrounds had tracking coefficients at the 50th, 70th, and 90th quantiles, which were 0.05 (−0.04; 0.15), 0.19 (0.06; 0.31), and 0.22 (0.02; 0.43) units higher, respectively, than children from high SEP groups.ConclusionTracking was consistently stronger at the higher quantiles of the BMI distribution. We observed suggestive evidence for a pattern of greater BMI tracking in lower (compared to higher) SEP groups in the more recently born cohort, particularly in women and at the higher end of the BMI distribution.
Loss of transglutaminase 2 sensitizes for diet-induced obesity-related inflammation and insulin resistance due to enhanced macrophage c-Src signaling
Authors: Sághy Tibor , Köröskényi Krisztina , Hegedűs Krisztina , Antal Miklós , Bankó Csaba , Bacsó Zsolt , Papp Attila , Stienstra Rinke , Szondy Zsuzsa 
Published: June 2019

AbstractTransglutaminase 2 (TG2) is a multifunctional protein that promotes clearance of apoptotic cells (efferocytosis) acting as integrin β3 coreceptor. Accumulating evidence indicates that defective efferocytosis contributes to the development of chronic inflammatory diseases. Obesity is characterized by the accumulation of dead adipocytes and inflammatory macrophages in the adipose tissue leading to obesity-related metabolic syndrome. Here, we report that loss of TG2 from bone marrow-derived cells sensitizes for high fat diet (HFD)-induced pathologies. We find that metabolically activated TG2 null macrophages express more phospho-Src and integrin β3, unexpectedly clear dying adipocytes more efficiently via lysosomal exocytosis, but produce more pro-inflammatory cytokines than the wild type ones. Anti-inflammatory treatment with an LXR agonist reverts the HFD-induced phenotype in mice lacking TG2 in bone marrow-derived cells with less hepatic steatosis than in wild type mice proving enhanced lipid clearance. Thus it is interesting to speculate whether LXR agonist treatment together with enhancing lysosomal exocytosis could be a beneficial therapeutic strategy in obesity.
SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes
Authors: Shi Chong-Shan , Nabar Neel R. , Huang Ning-Na , Kehrl John H. 
Published: June 2019

AbstractThe SARS (severe acute respiratory syndrome) outbreak was caused by a coronavirus (CoV) named the SARS-CoV. SARS pathology is propagated both by direct cytotoxic effects of the virus and aberrant activation of the innate immune response. Here, we identify several mechanisms by which a SARS-CoV open reading frame (ORF) activates intracellular stress pathways and targets the innate immune response. We show that ORF8b forms insoluble intracellular aggregates dependent on a valine at residue 77. Aggregated ORF8b induces endoplasmic reticulum (ER) stress, lysosomal damage, and subsequent activation of the master regulator of the autophagy and lysosome machinery, Transcription factor EB (TFEB). ORF8b causes cell death in epithelial cells, which is partially rescued by reducing its ability to aggregate. In macrophages, ORF8b robustly activates the NLRP3 inflammasome by providing a potent signal 2 required for activation. Mechanistically, ORF8b interacts directly with the Leucine Rich Repeat domain of NLRP3 and localizes with NLRP3 and ASC in cytosolic dot-like structures. ORF8b triggers cell death consistent with pyroptotic cell death in macrophages. While in those cells lacking NLRP3 accumulating ORF8b cytosolic aggregates cause ER stress, mitochondrial dysfunction, and caspase-independent cell death.
Vortex Shedding Optical Flowmeter based on Photonic Crystal Fiber
Authors: Arumuru Venugopal , Dash Jitendra Narayan , Dora Dhrubaraj , Jha Rajan 
Published: June 2019

AbstractIn the present work we propose a PCF (photonic crystal fiber) based Modal interferometer detector for sensing low flow velocity by detecting the frequency of vortices shed from a bluff body. The proposed novel design encapsulates the interferometric arm inside a metal casing to protect the sensor from harsh process fluids. The characterization of the developed probe is conducted under no flow conditions using a piezo actuator to evaluate the sensor response over wide frequency range (0–500 Hz). The developed sensors shows a reasonably flat response in the tested frequency range. Experiments are conducted by employing the developed sensor behind a bluff body of a vortex flowmeter to measure the frequency of the shed vortices and hence, the fluid flow rate. The low flow rate sensitivity of the vortex flowmeter is improved many folds by using the present sensor and the minimum Reynolds number detected is Re = 5000. A linear trend is observed between the frequency of the vortices and the flow velocity which is desirable for fluid flow measurement. The PCF based interferometric sensor with metal encapsulation makes the vortex flowmeter, sensitive at low flow rates, robust and economical to be used in industrial application.
Positive impact of Platelet-rich plasma and Platelet-rich fibrin on viability, migration and proliferation of osteoblasts and fibroblasts treated with zoledronic acid
Authors: Steller Daniel , Herbst Nele , Pries Ralph , Juhl David , Hakim Samer G. 
Published: June 2019

AbstractBisphosphonates are frequently used for the antiresorptive treatment in bone metastasis diseases or for osteoporosis. A side effect of this therapy is osteonecrosis of the jaw. This inhibits osteoclast function, but osteoblasts and fibroblasts are also negatively affected in terms of impaired proliferation. Additive local treatment with platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) promotes adhesion, proliferation and migration of cells due to high concentrations of growth factors like PDGF, TGF and IGF. The aim of the study was to investigate the effect of PRP or PRF on proliferation, migration and viability of osteoblasts and oral fibroblasts, treated with zoledronic acid (ZA). ZA treated fibroblasts and osteoblasts were exposed to PRP/PRF. Cell proliferation, migration and viability were measured using the real-time cell-analyzer assay (RTCA), the scratch assay and the MTT assay. There was a significant increase in closure of the scratch area by PRP/PRF treated osteoblasts (PRP = 40.6%, PRF = 100.0%, NC = 0.0%) as well as fibroblasts (PRP = 100.0%, PRF = 100.0%, NC = 12.7%) in comparison to the group of negative control (all p ≤ 0.05). Furthermore, the negative effect of ZA on cell migration was generally reduced in both cell lines using PRP/PRF. The viability and proliferation of cells decreased after exposure to ZA, whereas we observed an enhancement of cell viability within 24 hours by application of PRP/PRF in ZA treated cells. The negative effect of ZA on cell proliferation was especially reduced when using PRF. The use of PRF/PRP improves the behavior of ZA-treated cells, but PRF appears to have an advantage in comparison to PRP. This study demonstrates that treatment with PRF/PRP may have positive effects in the therapy of Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ).
Importance of planetary rotation for ventilation processes in deep elongated lakes: Evidence from Lake Garda (Italy)
Authors: Piccolroaz Sebastiano , Amadori Marina , Toffolon Marco , Dijkstra Henk A. 
Published: June 2019

AbstractVentilation mechanisms in deep lakes are crucial for their ecosystem functioning. In this paper we show the relevance of planetary rotation in affecting ventilation processes in relatively narrow, elongated deep lakes. Through a recent field campaign in Lake Garda (Italy), we provide explicit observational evidence for the development of lake-wide wind-driven secondary flows influenced by the Coriolis force in a narrow lake. The interpretation of these observations is supported by results from numerical simulations with a three-dimensional model of the lake. The results add an additional element, often neglected in narrow lakes, to be carefully considered when assessing the response of lakes to external forcing and climate change.
Cytoplasmic sequestration of the RhoA effector mDiaphanous1 by Prohibitin2 promotes muscle differentiation
Authors: Saleh Amena , Subramaniam Gunasekaran , Raychaudhuri Swasti , Dhawan Jyotsna 
Published: June 2019

AbstractMuscle differentiation is controlled by adhesion and growth factor-dependent signalling through common effectors that regulate muscle-specific transcriptional programs. Here we report that mDiaphanous1, an effector of adhesion-dependent RhoA-signalling, negatively regulates myogenesis at the level of Myogenin expression. In myotubes, over-expression of mDia1ΔN3, a RhoA-independent mutant, suppresses Myogenin promoter activity and expression. We investigated mDia1-interacting proteins that may counteract mDia1 to permit Myogenin expression and timely differentiation. Using yeast two-hybrid and mass-spectrometric analysis, we report that mDia1 has a stage-specific interactome, including Prohibitin2, MyoD, Akt2, and β-Catenin, along with a number of proteosomal and mitochondrial components. Of these interacting partners, Prohibitin2 colocalises with mDia1 in cytoplasmic punctae in myotubes. We mapped the interacting domains of mDia1 and Phb2, and used interacting (mDia1ΔN3/Phb2 FL or mDia1ΔN3/Phb2-Carboxy) and non-interacting pairs (mDia1H + P/Phb2 FL or mDia1ΔN3/Phb2-Amino) to dissect the functional consequences of this partnership on Myogenin promoter activity. Co-expression of full-length as well as mDia1-interacting domains of Prohibitin2 reverse the anti-myogenic effects of mDia1ΔN3, while non-interacting regions do not. Our results suggest that Prohibitin2 sequesters mDia1, dampens its anti-myogenic activity and fine-tunes RhoA-mDia1 signalling to promote differentiation. Overall, we report that mDia1 is multi-functional signalling effector whose anti-myogenic activity is modulated by a differentiation-dependent interactome. The data have been deposited to the ProteomeXchange with identifier PXD012257.
Different Synchrony in Rhythmic Movement Caused by Morphological Difference between Five- and Six-armed Brittle Stars
Authors: Wakita Daiki , Hayase Yumino , Aonuma Hitoshi 
Published: June 2019

AbstractPhysiological experiments and mathematical models have supported that neuronal activity is crucial for coordinating rhythmic movements in animals. On the other hand, robotics studies have suggested the importance of physical properties made by body structure, i.e. morphology. However, it remains unclear how morphology affects movement coordination in animals, independent of neuronal activity. To begin to understand this issue, our study reports a rhythmic movement in the green brittle star Ophiarachna incrassata. We found this animal moved five radially symmetric parts in a well-ordered unsynchronized pattern. We built a phenomenological model where internal fluid flows between the five body parts to explain the coordinated pattern without considering neuronal activity. Changing the number of the body parts from five to six, we simulated a synchronized pattern, which was demonstrated also by an individual with six symmetric parts. Our model suggests a different number in morphology makes a different fluid flow, leading to a different synchronization pattern in the animal.