bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethos Semi-Agentif : Intervention De Segolene Royal Sur Les Centrales Nucleaires
Authors: KORKUT Ece , GÜL Searp 
Published: April 2018

Un
discours politique se distingue d’autres genres de discours par le double
statut du locuteur qui représente moins lui-même que son adhésion à une
communauté. Dans cet article, il s’agit essentiellement de chercher la part de
l’agentivité et de la responsabilité du locuteur. Le corpus analysé est une
interview réalisée au journal télévisé de 20H de TF1 du 7 mars 2016, présenté
par Gilles Bouleau avec Ségolène Royal, la ministre de l’environnement et de
l’énergie. Le sujet de débat porte sur la fermeture éventuelle d’une centrale
nucléaire en France, conformément aux engagements du Parti socialiste qui était
au pouvoir. Bien qu’il s’agisse d’une interview, la méthodologie choisie n’est
pas l’analyse conversationnelle, mais l’analyse du discours. Ce sont le dire et
le dit de la ministre qui ont été analysés pour pouvoir révéler comment se
construit son ethos discursif autour d’un problème écologique. Quoiqu’elle ait
la légitimité de parole, de décision et d’action, la ministre se montre plutôt
réticente devant une solution décisive. Au lieu de donner une réponse précise,
elle opte pour une réponse conditionnelle et fortement modalisée, en délégant
sa part de responsabilité à des tiers. C’est ainsi que son ethos discursif se
manifeste comme quasi-agentif ou semi-agentif. Dans l’ensemble de cette
interview, l’ethos discursif de SR se dessine de la manière suivante :
éducateur, sceptique, hésitant, imprécis. Cet ethos qui se construit spontanément lors
de son discours peut provenir aussi bien des interventions insistantes de
l’interviewer que du positionnement incertain de son parti qui est au pouvoir.
« Il y a des mamans qui aiment le travail et des mamans qui aiment jouer » Reformulation orale, atelier d’écriture et compétences en littératie
Authors: Castany-Owhadi Hélène , Soulé Yves , Dreyfus Martine 
Published: April 2018

La présente étude explore le rôle des reformulations orales au sein d’un atelier d’écriture en première année du primaire, dans une visée compréhensive de l’activité conjointe[1] pour le développement des compétences en littératie. À partir d’un extrait de verbatim dans une classe particulièrement performante, nous étudions les jeux de reformulations entre l’enseignant et un élève en insécurité scripturale en mettant en évidence la complexité du processus d’étayage. [1] Au sens de Sensevy (2011) qui, dans sa théorie de l’action conjointe en didactique, affirme que l’on ne peut comprendre l’action de l’élève sans faire le lien avec l’action de l’enseignant dans le savoir.
A New Friction-Reducing Agent for Slickwater-Fracturing Treatments
Authors: Ibrahim Ahmed F. , Nasr-El-Din Hisham A. , Rabie Ahmed , Lin Genyao , Zhou Jian , Qu Qi 
Published: April 2018

Summary
Friction reducers (FRs) represent an essential component in any slickwater-fracturing fluid. Although the majority of previous research on these fluids has focused on evaluating the friction-reduction performance of chemical components, only a few studies have addressed the potential damage these chemicals can cause to the formation. Because of the polymeric nature of these chemicals—typically polyacrylamide (PAM)—an FR can either filter out onto the surface of the formation or penetrate deeply to plug the pores. In addition, breaking these polymers at temperatures lower than 200°F remains a problem. The present study introduces a new FR that replaces the linear gel with an enhanced proppant-carrying capacity and reduced potential for formation damage.
Friction-reduction performance, proppant settling, breakability, and coreflood experiments using tight sandstone cores at 150°F were conducted to investigate a new FR (FR1). The performance of the new FR was compared with two different FRs: a salt-tolerant polymer that is a copolymer of acrylamide and acrylamido-methylpropane sulfonate (FR2), and a guar-based polymer (FR3). Different breakers were used to examine the breakability of the three FRs, including ammonium persulfate (APS), sodium persulfate (SPS), hydrogen peroxide (HP), and sodium bromate (SB).
The friction reduction of the new chemical was higher than 70% in fresh water or 2 wt% potassium chloride (KCl) in the presence of calcium chloride (CaCl2) or choline chloride. The presence of 1 lbm/1,000 gal of different types of breakers did not affect the friction-reduction performance. The friction reduction of 1 gal/1,000 gal of the new FR1 was also higher than that of the guar-based FR3 at a load of 4 gal/1,000 gal at the same conditions. The results show that the new FR is breakable with any of the tested breakers. Among the four tested breakers, APS is the most-efficient breaker. Static and dynamic proppant-settling tests further indicated a superior performance of FR1 for proppant suspension compared with a PAM FR (FR2). Coreflood experiments showed that FR1 did not cause any residual damage to the core permeability when APS was used as a breaker, compared with 10% and 9% damage when FR2 and FR3 were tested, respectively. Coreflood tests also showed that FR1 is breakable using SB with only 2.5% damage, whereas FR2 and FR3 resulted in 47% and 41% damage, respectively. The results also show that higher salinity does not affect the breakability of the new FR.
The proposed FR shows higher friction-reduction performance and better proppant-carrying capacity with no formation damage, compared with the conventional counterparts. Hence, FR1 is a viable choice for application in fracturing formations with proppants.
The Demographic Characteristics of the Vardar Province and Issues of Self-Identification
Authors: Jovanović Vladan 
Published: April 2018

The paper analyzes the demographic structure of the south of the kingdom of Yugoslavia which was characterized by political instability, feudal heritage in economy and culture of living as well as a condition of permanent ethnic and religious antagonisms which arose from subjective mistakes made by the Yugoslav state as well as objective problems it had inherited (Albanian irredentism, activities of the IMRO backed by Bulgaria, Albania and Italy, passive resistance and fear within the population etc.). Aside from being an attempt at a demographic reconstruction of the area, the paper deals with issues of national, religious and political self-determination of the population inhabiting the Vardar region. The paper is based on unpublished archive material, statistical overviews and relevant literature.
Improved ciprofloxacin removal by a Fe(VI)-Fe3O4/graphene system under visible light irradiation
Authors: Fang Shunping , Zhou Zhengwei , Xue Jinjuan , He Guangyu , Chen Haiqun 
Published: April 2018

Abstract
In this paper, Fe3O4/graphene (Fe3O4/GE) nanocomposites were prepared by a co-precipitation method and characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and UV-vis diffuse reflectance spectra (UV-vis DRS). The composites were used in combination with Fe(VI) to construct a Fe(VI)-Fe3O4/GE system in order to degrade ciprofloxacin (CIP) in simulated water samples. The photocatalytic properties of Fe(VI)-Fe3O4/GE were evaluated under visible light irradiation. The concentration of CIP in solution was detected by high performance liquid chromatography (HPLC). A series of results showed that Fe(VI), as a good electron capture agent, could significantly improve the treatment performance. Major determining factors during CIP degradation were also investigated, in which solution pH of 9, Fe(VI) to Fe3O4/GE dosage ratio of 1:25 and GE content in the Fe3O4/GE nanocomposites of 10 wt% were found to be the best experimental conditions. The results demonstrated that the Fe(VI)-Fe3O4/GE system could offer an alternative process in water treatment in addition to the current Fe(VI)-UV/TiO2 process.
N-Acetyl Cysteine and Vitamin D Supplementation in Treatment Resistant Obsessive-compulsive Disorder Patients: A General Review
Authors: di Michele Flavia , Siracusano Alberto , Talamo Alessandra , Niolu Cinzia 
Published: April 2018

Objective: Obsessive-compulsive Disorder (OCD) is a disabling mental illness for which pharmacological
and psychosocial interventions are all too often inadequate. This demonstrates the need for more targeted
therapeutics. Recent preclinical and clinical studies have implicated the dysfunction of glutamatergic neurotransmission
in the pathophysiology of OCD. Moreover, there are studies suggesting that neuroimmune abnormalities
may play an important role in the pathogenesis of OCD. N-acetyl cysteine (NAC) is a safe and readily available
agent that would modify the synaptic release of glutamate in subcortical brain regions via modulation of the
cysteine-glutamate antiporter. The modulation of inflammatory pathways may also play a role in the benefits seen
following NAC treatment. Therefore NAC can be considered a neuroprotective agent.

Methods:
This paper explores the role of NAC in the treatment of OCD conditions refractory to first-line pharmacological
interventions, reviewing the clinical studies published in the last decade.

Results:
The possible benefit mechanisms of NAC for this disorder will be discussed, as well as the role of vitamin
D supplementation, given its specific property of stimulating the formation of glutathione in the brain.

Conclusion:
Nutraceutical supplementation in treatment resistance OCD may be important not only for improving
obsessive-compulsive symptomatology, but also from a psychological perspective, given its better acceptance
by the patients compared to pharmacological treatment.
Phytochemical Screening, Antiproliferative and Antioxidant Properties of Various Extracts from Endemic Origanum acutidens
Authors: Oke-Altuntas Feyza , Demirci Mehmet Ali , Demirtas Ibrahim , Yaglioglu Ayse Sahin , Behcet Lutfi 
Published: April 2018

Aim and Objective:
Origanum acutidens (Hand.–Mazz.) Ietsw. is an endemic and
perennial plant grown mainly in East Anatolia. Recently, natural plant products have attracted
interest due to their safety and therapeutic effects. Therefore, the aim of this study was to investigate
phytochemical contents and biological effects of Origanum acutidens.

Materials and Methods:
The aerial parts of O. acutidens were extracted with water, ethyl acetate, nbutanol,
and methanol/chloroform solvents. Phenolic compounds and other constituents of the
extracts were analyzed by HPLC/TOF-MS. The Ethyl Acetate extract (EA) was fractionated by flash
chromatography. The extracts and fractions were investigated for their antiproliferative activities on
human cervical adenocarcinoma (HeLa) cell line by using BrdU ELISA assay. Antioxidant activities
of the extracts and fractions were evaluated by complementary test systems, namely determination of
total phenolic contents, metal chelating ability and DPPH radical scavenging assay.

Results:
Among the extracts, Ethyl Acetate extract (EA) exhibited the highest antiproliferative
activity (IC50 = 15.71 ± 0.04 µg/mL) on HeLa cells. It was therefore fractionated by flash
chromatography to obtain 10 fractions which were investigated for their phenolic compounds and
bioactivities. Rosmarinic acid was determined as the major component of EA and its fractions. EA
exhibited higher antiproliferative activity against HeLa cell line than its fractions and 5-fluorouracil
(5-FU) at the concentration of 100 µg/mL. EA and its fractions (F10, F6, F4, F7, F3, and F2)
displayed higher radical scavenging activity compared to Butylated Hydroxytoluene (BHT). These
effects may be attributed to the presence of rosmarinic acid in EA and its active fractions.

Conclusion:
This study demonstrated that O. acutidens is an essential natural source of polyphenols
and a potent natural antioxidant and antiproliferative agent for food and pharmaceutical industries.
Methodologies Related to Computational Models in View of Developing Anti-Alzheimer Drugs: An Overview
Authors: Baheti Kirtee , Kale Mayura 
Published: April 2018

Background:
Since the last two decades, there has been more focus on the
development strategies related to Anti-Alzheimer’s drug research. This may be attributed to the
fact that most of the Alzheimer's cases are still mostly unknown except for a few cases, where
genetic differences have been identified. With the progress of the disease, the symptoms involve
intellectual deterioration, memory impairment, abnormal personality and behavioural patterns,
confusion, aggression, mood swings, irritability Current therapies available for this disease give
only symptomatic relief and do not focus on manipulations of biololecular processes.

Methods:
Nearly all the therapies to treat Alzheimer's disease, target to change the amyloid
cascade which is considered to be important in AD pathogenesis. New drug regimens are not able
to keep pace with the ever-increasing understanding about dementia at the molecular level.
Looking into these aggravated problems, we thought to put forth molecular modeling as a drug
discovery approach for developing novel drugs to treat Alzheimer disease. The disease is incurable
and it gets worst as it advances and finally causes death. Due to this, the design of drugs to treat
this disease has become an utmost priority for research. One of the most important emerging
technologies applied for this has been Computer-assisted drug design (CADD). It is a research tool
that employs large-scale computing strategies in an attempt to develop a model receptor site which
can be used for designing of an anti-Alzheimer drug.

Results:
Various models of amyloid-based calcium channels have been computationally optimized.
Docking and De novo evolution are used to design the compounds. They are further subjected to
absorption, distribution, metabolism, excretion and toxicity (ADMET) studies to finally bring
about active compounds that are able to cross BBB. Many novel compounds have been designed
which might be promising ones for the treatment of AD.

Conclusion:
The present review describes the research carried out on various heterocyclic
scaffolds that can serve as lead compounds to design Anti-Alzheimer’s drugs in the future. The
molecular modeling methods can thus become a better alternative for the discovery of newer Anti-
Alzheimer agents. This methodology is extremely useful to design drugs in minimum time with
enhanced activity keeping balanced ethical considerations. Thus, the researchers are opting for this
improved process over the conventional methods hoping to achieve a sure shot way out for the
sufferings of people affected by Alzheimer besides other diseases.<P&gt;
Comparative Analysis of DNA Motif Discovery Algorithms: A Systemic Review
Authors: Hashim Fatma A. , Mabrouk Mai S. , Atabany Walid A.L. 
Published: April 2018

Background:
Bioinformatics is an interdisciplinary field that combines biology and information
technology to study how to deal with the biological data. The DNA motif discovery
problem is the main challenge of genome biology and its importance is directly proportional to increasing
sequencing technologies which produce large amounts of data. DNA motif is a repeated
portion of DNA sequences of major biological interest with important structural and functional
features. Motif discovery plays a vital role in the antibody-biomarker identification which is useful
for diagnosis of disease and to identify Transcription Factor Binding Sites (TFBSs) that help in
learning the mechanisms for regulation of gene expression. Recently, scientists discovered that the
TFs have a mutation rate five times higher than the flanking sequences, so motif discovery also
has a crucial role in cancer discovery.

Methods:
Over the past decades, many attempts use different algorithms to design fast and accurate
motif discovery tools. These algorithms are generally classified into consensus or probabilistic
approach.

Results:
Many of DNA motif discovery algorithms are time-consuming and easily trapped in a local
optimum.

Conclusion:
Nature-inspired algorithms and many of combinatorial algorithms are recently proposed
to overcome the problems of consensus and probabilistic approaches. This paper presents a
general classification of motif discovery algorithms with new sub-categories. It also presents a
summary comparison between them.
SAĞLIK YÖNETİMİ BÖLÜMÜ ÖĞRENCİLERİNİN İLETİŞİM BECERİLERİ İLE SOSYAL MEDYA KULLANIMLARI ARASINDAKİ İLİŞKİNİN BELİRLENMESİ
Authors: TURGUT Meryem , KUTLU Gamze , MUT Sinem 
Published: April 2018

Amaç: Sağlık
yönetimi bölümü öğrencilerinin iletişim becerileri ve sosyal medya kullanımı
düzeylerini belirlemek
ve iletişim becerileri ile sosyal medya kullanım düzeyleri arasındaki ilişkiyi
ortaya koymaktır.Yöntem: Çalışmanın evrenini Ankara Üniversitesi Sağlık Yönetimi
Bölümü’nde eğitimine devam eden toplam 338 öğrenci oluşturmaktadır. Çalışmada
örneklem seçilmemiş olup, evrenin tamamına ulaşılmaya çalışılmıştır. Buna
göre, toplam 273 öğrenci katılmış olup
evrenin %81’ine ulaşılmıştır. İletişim
becerileri düzeyini ölçmek için İletişim Becerileri Envanteri, sosyal medya
kullanım düzeyini ölçmek için ise Sosyal
Medya Kullanımı Ölçeği’nden yararlanılmıştır.Bulgular: Araştırmaya katılan öğrencilerin
iletişim becerileri ölçeğinden aldıkları toplam puan ortalaması 104,16±15,69’dir.
Erkek öğrencilerin iletişim
becerileri puan ortalamasının kadınlara göre yüksek olduğu saptanmıştır. Ayrıca
1. sınıf öğrencilerinin 2., 3., ve 4. sınıf öğrencilerine göre iletişim becerileri
puanlarının daha düşük olduğu bulunmuştur. Ev arkadaşıyla birlikte yaşayan
öğrencilerin ailesiyle birlikte yaşayanlara göre iletişim becerileri puan
ortalamalarının daha yüksek olduğu tespit edilmiştir. Öğrencilerin
sosyal medya kullanımından aldıkları puan ortalaması ise 21,84±9,13’dir ve sosyal
medya kullanımının en fazla olduğu grup 4. sınıf öğrencileridir. Korelasyon analizi
sonuçlarına göre, genel
sosyal medya kullanımı ile genel iletişim becerileri arasında (r=0,151)
istatistiksel açıdan anlamlı ve pozitif yönlü ilişkiler olduğu tespit
edilmiştir. Son olarak regresyon analizi sonuçları da sosyal medya kullanımının iletişim
becerilerindeki toplam varyansın %3,9’unu açıklamaktadır.

Sonuç: Öğrencilerin iletişim becerileri
düzeyleri ile sosyal medya kullanım düzeyleri arasında pozitif yönlü, zayıf bir
ilişki olduğu tespit edilmiştir. Elde edilen bu sonuca göre araştırmaya katılan
öğrencilerin iletişim becerileri düzeylerinin sosyal medya kullanım düzeyleri
ile ilişkili olduğu ve öğrencilerin sosyal medya kullanımının iletişim becerilerini
artırdığı söylenebilir.
Survey of Kidney Biopsy Clinical Practice and Training in the United States
Authors: Yuan Christina M. , Nee Robert , Little Dustin J. , Narayan Rajeev , Childs John M. , Prince Lisa K. , Raghavan Rajeev , Oliver James D. ,   for the Nephrology Education Research and Development Consortium (NERDC)
Published: April 2018

Background and Objectives
Practicing clinical nephrologists are performing fewer diagnostic kidney biopsies. Requiring biopsy procedural competence for graduating nephrology fellows is controversial.

Design, Setting, Participants, & Measurements
An anonymous, on-line survey of all Walter Reed training program graduates (n=82; 1985–2017) and all United States nephrology program directors (n=149; August to October of 2017), regarding kidney biopsy practice and training, was undertaken.

Results
Walter Reed graduates’ response and completion rates were 71% and 98%, respectively. The majority felt adequately trained in native kidney biopsy (83%), transplant biopsy (82%), and tissue interpretation (78%), with no difference for ≤10 versus >10 practice years. Thirty-five percent continued to perform biopsies (13% did ≥10 native biopsies/year); 93% referred at least some biopsies. The most common barriers to performing biopsy were logistics (81%) and time (74%). Program director response and completion rates were 60% and 77%. Seventy-two percent cited ≥1 barrier to fellow competence. The most common barriers were logistics (45%), time (45%), and likelihood that biopsy would not be performed postgraduation (41%). Fifty-one percent indicated that fellows should not be required to demonstrate minimal procedural competence in biopsy, although 97% agreed that fellows should demonstrate competence in knowing/managing indications, contraindications, and complications. Program directors citing ≥1 barrier or whose fellows did <50 native biopsies/year in total were more likely to think that procedural competence should not be required versus those citing no barriers (P=0.02), or whose fellows performed ≥50 biopsies (P<0.01).

Conclusions
Almost two-thirds of graduate respondents from a single military training program no longer perform biopsy, and 51% of responding nephrology program directors indicated that biopsy procedural competence should not be required. These findings should inform discussion of kidney biopsy curriculum requirements.
Are the FAIR Data Principles fair?
Authors: Dunning Alastair , De Smaele Madeleine , BÃ¶hmer Jasmin 
Published: April 2018

This practice paper describes an ongoing research project to test the effectiveness and relevance of the FAIR Data Principles. Simultaneously, it will analyse how easy it is for data archives to adhere to the principles. The research took place from November 2016 to January 2017, and will be underpinned with feedback from the repositories.
The FAIR Data Principles feature 15 facets corresponding to the four letters of FAIR - Findable, Accessible, Interoperable, Reusable. These principles have already gained traction within the research world. The European Commission has recently expanded its demand for research to produce open data. The relevant guidelines1are explicitly written in the context of the FAIR Data Principles. Given an increasing number of researchers will have exposure to the guidelines, understanding their viability and suggesting where there may be room for modification and adjustment is of vital importance.
This practice paper is connected to a dataset(Dunning et al.,2017) containing the original overview of the sample group statistics and graphs, in an Excel spreadsheet. Over the course of two months, the web-interfaces, help-pages and metadata-records of over 40 data repositories have been examined, to score the individual data repository against the FAIR principles and facets. The traffic-light rating system enables colour-coding according to compliance and vagueness. The statistical analysis provides overall, categorised, on the principles focussing, and on the facet focussing results.
The analysis includes the statistical and descriptive evaluation, followed by elaborations on Elements of the FAIR Data Principles, the subject specific or repository specific differences, and subsequently what repositories can do to improve their information architecture.

(1) H2020 Guidelines on FAIR Data Management:http://ec.europa.eu/research/participants/data/ref/h2020/grants_manual/hi/oa_pilot/h2020-hi-oa-data-mgt_en.pdf
THE EFFECT OF HEDONIC LIFESTYLE, HEDONIC MOTIVATION AND QUALITY OF PRODUCTS TO INTEREST RECYCLING TUPPERWARE PRODUCT IN JAMBI CTY
Authors: Johannes Johannes , Octavia Ade , Suwarti Yemmi 
Published: April 2018

This study aims to analyze the influence of hedonic lifestyle, hedonic motivation and product quality simultaneously and partially to the interest of buy back Tupperware product in Jambi City. The population is Tupperware consumers in PT. Nazila Jambi Nugraha which amounted to 28,106 members. After doing research data that can author though only 139 questionnaires. Data collection method in this study using survey method, followed by statistical methods to test the hypothesis is by multiple linear regressions (multiple regressions). The results showed that the hedonic lifestyle, hedonic motivation and product quality had a positive and significant influence on repurchase interest. Where product quality has a more dominant influence when compared to two other variables. Based on the results of the study for it is expected to the future management company can continue to maintain and improve product quality one of them is by diversifying the product.
Keywords: Hedonistic lifestyle, hedonic motivation, quality of products and repurchase intention.