bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disproportionality analysis of oesophageal toxicity associated with oral bisphosphonates using the FAERS database (2004–2023)
Authors: Chen Lin , Dai Zhicheng , Song Huangrong , Zhang Jiafeng , Li Tuo 
Published: November 2024

BackgroundThis study analyzed the FDA’s Adverse Event Reporting System (FAERS) data to investigate the correlation between oral bisphosphonates (BPs) and oesophageal adverse events (AEs).MethodsWe systematically extracted data on adverse reactions to oral alendronate, risedronate, and ibandronate from the FAERS database, covering the period from the 2004 Q1 to the 2023 Q4. The role_code of AEs mainly includes primary suspect (PS), secondary suspect (SS), concomitant (C), and interaction (I). This study targeted reports with a role_code of “PS.” According to the FDA deduplication rule, the latest FDA_DT is selected when the CASEID is the same, and the higher PRIMARYID is selected when the CASEID and FDA_DT are the same. Our analysis leveraged four statistical methods, including the reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and the multi-item gamma Poisson shrinker (MGPS), to assess the relationship between oral bisphosphonates and oesophageal AEs. The Kaplan-Meier method was utilized to evaluate the cumulative incidence of oesophageal toxicity, while the log-rank test examined the temporal onset profiles of these toxicities. Additionally, the Pearson chi-squared test was employed to identify any significant differences in mortality and hospitalization rates associated with the oesophageal AEs caused by these medications.ResultsThe FAERS database had 41,590 AE reports for oral BPs, with 3,497 (8.41%) related to oesophageal AEs. Our findings indicate that oral BPs are disproportionately associated with an increased incidence of gastrointestinal system AEs at the system organ class (SOC) level. The adverse events identified at the preferred terms (PTs) level encompassed conditions such as gastroesophageal reflux disease, oesophagitis, and oesophageal pain. A significant divergence in the cumulative incidence of oesophageal AEs was observed among patients treated with the three different oral bisphosphonates, as confirmed by the log-rank test (p &lt; 0.0001). Hospitalization rates varied significantly among patients receiving different BPs (p &lt; 0.05), but no significant difference in mortality rates was found.ConclusionThe study establishes a significant link between oral BPs and oesophageal toxicity, highlighting the need for further research into the mechanisms of BP-induced oesophageal toxicity and potential preventive measures.
Impact of ischemic preconditioning combined with aerobic exercise on 24-h ambulatory blood pressure in men with prehypertension and stage 1 hypertension
Authors: Jang Min-Hyeok , Kim Dae-Hwan , Han Jean-Hee , Kim Seok-Ho , Kim Jung-Hyun 
Published: November 2024

IntroductionA single bout of aerobic exercise is known to induce a temporary reduction in post-exercise blood pressure termed post-exercise hypotension (PEH). Meanwhile, an ischemic preconditioning (IPC), a series of short ischemia-reperfusion intervention, has also shown antihypertensive effects showing a potential nonpharmacologic intervention for hypertension. While the acute BP reduction effects of aerobic exercise and IPC are individually well-investigated, it remains unclear if combining both interventions has an additive effect on PEH.MethodsA total of twelve pre- or hypertensive men (six prehypertension, six stage 1 hypertension) underwent either 30 min of aerobic exercise at 50% VO2peak (CON) or IPC before exercise, in a counterbalanced order. IPC involved inflating cuffs on both thighs to 200 mmHg for 5 min, alternating between right and left thighs for three cycles, totaling 30 min. Brachial BP was measured during exercise and 1-h post-exercise recovery whereas muscle oxygen saturation (SmO2) from the rectus femoris was monitored using NIRs during exercise and recovery. Heart rate variability (HRV) and baroreflex sensitivity (BRS) together with a head-up tilt test (at 0 and 50°) were measured at the pre-test, post-test, and 24-h post-test. After the completion of each experiment, 24-h ambulatory blood pressure (ABP) was monitored to assess post-exercise hypotension within a 24-h window.ResultsBP and heart rate responses during exercise and 1-h recovery did not differ between conditions while SmO2 was significantly elevated during exercise in IPC (p = 0.004). There was no difference in HRV and supine BRS. However, significantly reduced titled BRS after exercise was found in CON while IPC preserved BRS similar to pre-exercise value, extending to 24-h post period (p = 0.047). ABP monitoring revealed a significant reduction in systolic BP during sleep in IPC compared to CON (p = 0.046).ConclusionThe present findings suggest that IPC with a single session of aerobic exercise results in a notable decrease in systolic ABP, particularly during sleep, compared to aerobic exercise alone. This supplementary antihypertensive effect was associated with a sustained BRS, persisting up to 24 h in contrast to the significant decrease observed in CON. Future studies are warranted to investigate long-term adaptations to IPC.
A cross-sectional evaluation of binge-eating behavior and its correlation with anxiety disorders among adolescents in Northern Saudi Arabia: implications for future generations
Authors: Alhuwaydi Ahmed M. 
Published: November 2024

Background and aimBinge-eating behavior and anxiety disorders pose a significant public health issue worldwide, as it has severe implications for both the physical and mental health of the adolescent population. The present study evaluated the prevalence of binge-eating behavior, anxiety disorders, and associated factors among the northern Saudi adolescent population. Furthermore, we assessed the correlation between binge eating and anxiety.MethodsThe present population-based cross-sectional study was carried out among adolescents in the Aljouf region of Saudi Arabia from June 2023 to December 2023. A total of 384 eligible participants were selected using the convenience sampling method. The present study used a pretested Arabic version of the binge eating scale (BES) and Hamilton Anxiety Scale (HAM-A) to assess the binge-eating behavior and anxiety disorders among the target population. The Spearman correlation test determined the strength and direction of the correlation between BES and HAM-A scores. Furthermore, logistic regression analysis was applied to find the associated factors for binge-eating behavior among the study participants.ResultsOf the 384 participants, moderate and severe binge-eating behaviors were found among 11.2% and 8.3% of the respondents, respectively. Regarding the severity of anxiety as assessed by the HAM-A scale, mild, moderate, and severe anxiety were shown among 12.8%, 9.6%, and 7.5% of the participants, respectively. Also, the study found a positive correlation between binge eating and anxiety scores, with a correlation coefficient of 0.26 and a p-value of 0.001. Furthermore, being female (p = 0.001), moderate (p = 0.004), and severe anxiety (P = 0.001) were significantly associated with binge-eating behavior.ConclusionThe present research findings advocate for the implementation of targeted interventions and support services aimed at decreasing binge-eating behavior and anxiety, thereby promoting the overall well-being of adolescents and building stronger future generations. Moreover, it is recommended that optional courses about binge eating be incorporated into the curricula of schools and universities.
Multimorbidity patterns in dementia and mild cognitive impairment
Authors: Valdevila Figueira José Alejandro , Valdevila Santiesteban Rocío , Carvajal Parra Indira Dayana , Benenaula Vargas Luis Patricio , Ramírez Andrés , Leon-Rojas Jose E. , Rodas Jose A. 
Published: November 2024

DesignThis is a retrospective cohort study. Setting: The study was conducted at the Instituto de Neurociencias de la Junta de Beneficencia de Guayaquil, a primary neuroscience institute in Ecuador.ParticipantsThe study evaluated 425 participants diagnosed with Mild Cognitive Impairment (MCI) or dementia, out of which 272 individuals (mean age = 75 years; 164 female) presenting specific medical conditions were selected for analysis.MeasurementsData were collected on demographics, medical history, and neuropsychological assessment using the Neuropsi scale. Conditions such as Type 2 Diabetes Mellitus, hypertension, obesity, and history of traumatic brain injury were specifically noted.ResultsLatent Class Analysis identified three distinct classes of patients: Unspecified Cognitive Deterioration, Dementia, and MCI. The three-class model provided the best fit, revealing varied morbidity patterns and highlighting the influence of vascular and metabolic conditions on cognitive decline. Notably, similarities in hypertension and diabetes prevalence between Dementia and MCI classes suggested shared risk factors. The study also found no significant age differences between the classes, indicating that age alone might not be the primary determinant in the progression of cognitive decline.ConclusionsThe study underscores the complexity of dementia and MCI in an ageing Ecuadorian population, with vascular health playing a crucial role in cognitive impairment. These findings advocate for a holistic approach in managing dementia and MCI, emphasising the importance of addressing cardiovascular and metabolic health alongside neurocognitive care. The distinct morbidity patterns identified offer insights into tailored intervention strategies, highlighting the need for comprehensive, multidisciplinary care in dementia management.
Socio-demographic determinants of dietary choices and their impact on health in Spanish adults
Authors: Sandri Elena , Cantín Larumbe Eva , Capoferri Michela , Cerdá Olmedo Germán , Werner Lisa Ursula , Vega-Bello M. Jesús 
Published: November 2024

BackgroundAlthough Spain has traditionally followed the Mediterranean diet, in recent years, changes have become noticeable in the food preferences of the population. These changes include adopting new diets and dietary trends, such as plant-based diets, intermittent fasting and raw food diets. These choices are influenced by cultural, social and socio-demographic factors, and their impact on health should be studied in detail.AimThe objectives of this research are: (1) to study the prevalence of different dietary patterns among the Spanish population, (2) to explore the dependence of dietary choice on socio-demographic factors, (3) to investigate the relationship between the social habits and lifestyle choices of the population and how it affects health.MethodsA descriptive cross-sectional study was carried out on the Spanish population. Using a questionnaire constructed and validated by the research team, socio-demographic data were collected and different nutritional, social and lifestyle habits of the targeted population were explored.ResultsA valid sample of 22,181 people was collected among which 17,573 (79.2%) people claimed to follow a Mediterranean dietary pattern, 1,425 (6.4%) people followed a plant-based diet, 365 (1.6%) people are vegans, 1,018 people (4.6%) practiced intermittent fasting, 252 (1.1%) people followed a raw food diet and 1,548 people (7%) claimed to follow other types of diets. The data show that younger people (18–25 years old) tend to adopt more often a plant-based diet than older people and that women tend to follow this type of diet more often than men. On the other hand, men seem to practice intermittent fasting more frequently. A higher tendency to practice a raw food diet was found among people living in villages than those living in cities. Moreover, some trends were found in different regions of Spain, with greater adherence to a plant-based diet in Catalonia, while intermittent fasting is more common in the Region of Murcia. Finally, the results indicate that individuals who pay attention to their diet and experiment with various dietary patterns are generally more health-conscious. This is reflected in their adoption of healthier behaviors, such as exercising more and reducing their intake of alcohol and sugary drinks.
Open laminectomy vs. minimally invasive laminectomy for lumbar spinal stenosis: a review
Authors: Dhar Utpal K. , Menzer Emma Lilly , Lin Maohua , O’Connor Timothy , Ghimire Nischal , Dakwar Elias , Papanastassiou Ioannis D. , Aghayev Kamran , Tsai Chi-Tay , Vrionis Frank D. 
Published: November 2024

ObjectivesLumbar spinal stenosis (LSS) refers to a narrowing of the space within the spinal canal, which can occur at any level but is most common in the lumbar spine. Open laminectomy and minimally invasive laminectomy (MIL) procedures are the most common surgical gold standard techniques for treating LSS. This study aims to review clinical and biomechanical literature to draw comparisons between open laminectomy and various MIL techniques. The MIL variation comprises microendoscopic decompression laminotomy, unilateral partial hemilaminectomy, and microendoscopic laminectomy.MethodsA review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We reviewed 25 clinical, 6 finite element, and 3 cadaveric studies associated with treating LSS. We reviewed literature that discusses factors such as operation time, length of hospital stay, postoperative complications, reoperation rate, effect on elderly patients, patients’ satisfaction, and adjacent segment disease degeneration for the clinical studies, whereas the range of motion (ROM), von Mises stresses, and stability was compared in biomechanical studies.ResultsMIL involves less bone and ligament removal, resulting in shorter hospital stays and lower reoperation and complication rates than open laminectomy. It improves the quality of health-related living standards and reduces postoperative pain. Biomechanical studies suggest that laminectomy and facetectomy increase annulus stress and ROM, leading to segmental instability.ConclusionAlthough theoretically, MIL means less tissue injury, pain, and faster recovery in the short term, the long-term results depend on the adequacy of the decompression procedure and tend to be independent of MIL or open laminectomy.
Vascular Reconstruction of Multiple Renal Arteries—A Risk Factor for Transplant Renal Artery Stenosis: Insight From a Matched Case-Control Study
Authors: Choudhary Devprakash , Vijayvergiya Rajesh , Kishore Kamal , Subramani Vanji Nathan , Banoth Mohan , Reddy Perugu Sai Praneeth , Mandwar Milind , Bamaniya Bharat , Panjathia Arun , Gupta Parul , Patil Shiva Kumar S. , Sethi Jasmine , Gorsi Ujjwal , Singh Sarbpreet , Kenwar Deepesh , Sharma Ashish 
Published: November 2024

Transplant Renal Artery Stenosis (TRAS) is the leading vascular complication following kidney transplantation (KT), causing premature allograft loss and increased post-KT mortality. While risk factors for TRAS, such as prolonged cold ischemia time and delayed graft function, are well-documented in deceased donor-KT, the risk factors remain less clearly defined in living donor-KT. This matched case-control study, conducted at a leading national transplant center predominantly performing living donor-KT, evaluated risk factors and long-term outcomes of clinical TRAS (cTRAS). cTRAS cases diagnosed from January 2009 to December 2022 were matched with four control kidney transplant recipients (KTRs) in a study powered to assess whether ex-vivo arterial vascular reconstruction of multiple renal arteries (VR-MRA) increases the risk of cTRAS. Among 2,454 KTs, 28 KTRs (1.14%) were diagnosed with cTRAS around 3.62 ± 1.04 months post-KT, with renal allograft dysfunction (92.86%) as the most common presenting feature. Notably, 27 cTRAS cases were successfully treated with endovascular intervention, yielding favorable outcomes over a 6–180 months follow-up period. The study identified ex-vivo VR-MRA as an independent risk factor for cTRAS (P &lt; 0.001). cTRAS cases receiving timely treatment exhibited long-term outcomes in graft and patient survival similar to control KTRs. Early screening and timely intervention for cTRAS post-KT may improve graft and patient outcomes.
Research on the Spatial Distribution Characteristics and Inhalation Health Risk Assessment of Bacterial Aerosols in Spraying Environments
Authors: Gao Qian , Dai Miao , Lei Guangyu , Hou Xiandong , Zhang Dawei , Du Weiwei 
Published: November 2024

As a key water source for urban landscape entertainment and miscellaneous municipal uses, the reuse safety of reclaimed water has attracted much attention. Given the deficiencies in the current research on bacterial aerosol-related risks, this study conducted systematic research on the spatial distribution law of bacterial aerosols in spraying environments and the exposure characteristics of various populations through simulated spraying experiments and population surveys, and on this basis, quantitatively evaluated the inhalation risk of bacterial aerosols. Results indicated that the concentration of bacterial aerosols in the spatial position within the water source and their residence time at different positions were related to the bacterial concentration of the sprayed water source. Specifically, the concentration of bacterial aerosols and the atomization factor decreased with the increase in the horizontal distance from the nozzle, and reached a saturated state at the eighth minute after the nozzle started spraying. At a height of 1.5 m, and at distances of 1 m, 2 m, 3 m, and 4 m from the nozzle, the atomization coefficients (mL water/m3 air) were 30.25, 8.52, 0.81, and 1.33 × 10−3, respectively. However, the particle size distribution of bacterial aerosols in space was independent of the bacterial concentration in the water source. The peak particle size of bacterial aerosols was between 2.1 and 4.7 µm, and its concentration accounts for more than 50%. Based on the above results, the exposure characteristics of the instantaneous contact time of the crowd exposed to the spray water of park lawn irrigation and the spray water of sprinklers on roads were obtained through simulated shooting experiments. Results showed that under the same environment, when people were exposed to the spray of park lawn irrigation and the spray of sprinklers on roads, the health risk of a single inhalation was relatively high. The single health risk of the crowd manifested as follows: adult males > adult females > children; however, none of them exceed the acceptable risk level of 10−3. The research findings of this paper can provide a scientific basis for the safe reuse of reclaimed water
Prisma
Authors: Bjuggfält Makz , Mattei Lou 
Published: November 2024

I denna text reflekterar Makz Bjuggfält och Lou Mattei över instiftandet och förvaltandet av det queerlitterära priset Prisma Litteraturpris. Prisma Litteraturpris grundades av PAGE 28 och Bögbibblan och delades ut första gången i december 2023. Prisma är ett ideellt projekt som kommer att fortsätta att uppmärksamma och prisa nordisk queer litteratur och skapa mötesplatser för nordiska queers.
Caracterização anatômica do forame palatino maior em crânios secos
Authors: Sousa Cristina Freitas de , Santos Luyra Elyka Daniel dos , Brasil Arthur Willian de Lima , Andrade Arthur Felipe de Brito , Paiva Monique Danyelle Emiliano Batista , Lucena Luciana Barbosa Sousa de , Sousa Eliane Marques Duarte de 
Published: November 2024

O forame palatino maior (FPM) é uma estrutura anatômica encontrada no palato duro no qual emerge o feixe vásculo-nervoso palatino maior, sendo responsável pela inervação e vascularização da região posterior do palato duro. O objetivo desse trabalho foi determinar a localização do forame palatino maior, bem como sua morfologia em crânios secos da Universidade Federal da Paraíba. A amostra da pesquisa foi composta por 45 crânios de adultos, de ambos os sexos, sendo 5 crânios dentados e 40 crânios desdentados. Procedeu-se às medições utilizando-se um paquímetro digital (Zaas Precision, Amatools ®) e a mensuração das distâncias foi feita em uma escala milimétrica. Os dados coletados provenientes dos crânios foram plotados em uma planilha do Microsoft Excel. Todas as análises foram realizadas no aplicativo SPSS 25 for Mac com nível de significância de 5%. Todos os crânios possuíam forames palatinos maiores e menores nos lados direito e esquerdo. A localização mais frequentemente encontrada foi na linha média do terceiro molar superior, a orientação mais predominante foi a inferior/vertical, a morfologia mais prevalente foi a oval, o formato do palato duro mais frequente foi em forma de U. Conhecer a localização e morfologia do forame palatino maior é de extrema relevância para o cirurgião-dentista, visto que o mesmo se depara com essa estrutura anatômica durante procedimentos clínicos e cirúrgicos.
Pemberdayaan Dan Pengelolaan Toga Antidiabetik Sebagai Upaya Preventif Terhadap Penyakit Diabetes Dan Peningkatan Kemandirian Kesehatan Masyarakat Di Desa Renon
Authors: Damayanti Ida Ayu Manik , Antari Ni Wayan Sukma , Megayanti Sri Dewi , Harditya Kadek Buja , Wulansari Nadya Treesna , Dharmapatni Ni Wayan Kesari , Kusuma Ida Bagus Separsa , Aristadewi Ida Ayu Mas , Artha I Wayan Oktapratama , Suweca I Gede 
Published: November 2024

Fokus pembangunan masyarakat bukan hanya bidang kemandirian pangan, namun juga bidang kemandirian kesehatan melalui pembudidayaan dan pemanfaatan tanaman obat keluarga (TOGA). Seringkali masyarakat hanya tahu dalam hal menanam tanpa mengetahui kegunaannya tanaman tersebut. Kegiatan ini bertujuan untuk meningkatkan pengetahuan serta ketrampilan masyarakat dalam pemberdayaan dan pengelolaan TOGA antidiabetik sebagai upaya preventif terhadap penyakit diabetes. Pelaksanaan kegiatan ini dilakukan dengan metode Community Development. Hasil kegiatan menunjukkan adanya peningkatan pengetahuan masyarakat awal kegiatan yaitu kategori kurang dengan rata-rata nilai 4,74. Setelah mengikuti seluruh rangkaian kegiatan, hasil post-test menunjukkan rata-rata pengetahuan peserta mengalami peningkatan menjadi 8,10 atau kategori baik. Pengabdian kepada masyarakat yang dilakukan dapat meningkatkan pengetahuan masyarakat tentang pemanfaatan dan pengelolaan TOGA antidiabetik yang terdiri dari tanaman pegagan (Centella asiatica), tanaman sambiloto (Andrographis paniculata) dan tanaman binahong (Anredera cordifolia) sebagai bahan alam dalam upaya preventif mengendalikan kadar gula darah.

Kata kunci : Antidiabetes, kemandirian kesehatan, TOGA
Tanggapan Iman Kristen Terhadap Pandangan-pandangan Teologi Feminis
Authors: Andi Yusuf Etni Grace , Sugiharto Ayub , Iyai Fincen 
Published: November 2024

Tujuan penelitian ini adalah untuk menemukan bagaimana tanggapan iman Kristen terhadap perkembangan teologi feminis yang di mulai dari sebuah gerakan di Inggris pada abad 17 berkembang pesat di abad 19 dan 20 dalam bentuk sebuah ajaran atau teologi. Teologi feminis tergolong dalam teologi pembebasan dimana pengaruhnya begitu besar merasuki perkembangan teologi kekristenan dalam gereja. Berdasarkan penelitian, karakter paling jelas dari gerakan feminisme adalah lebih kepada bentuk protes terhadap sikap subordinansi gender dan diskriminasi kaum perempuan yang telah terjadi selama berabad-abad baik di dunia sekuler maupun di dalam kehidupan iman Kristen atau gereja. Istilah feminis itu sendiri telah menimbulkan anggapan yang menimbulkan pengharapan sekaligus ketakutan. Oleh sebab itu perlu pemahaman tentang sejarah latar belakang munculnya teologi feminis dalam dunia kekristenan, supaya orang percaya atau gereja masa kini waspada pada bahaya perkembangan teologi-teologi kontemporer termasuk teologi feminis ini, sehingga gereja masa kini dapat siap menghadapi berbagai dampaknya. Dengan menggunakan metode penelitian kualitatif deskriptif yang menggunakan pendekatan studi kepustakaan, diketahui bahwa ada beberapa pandangan teologi feminis yang bisa membahayakan dalam kehidupan kekristenan. Selain itu ditemukan pula bahwa terdapat beberapa tanggapan yang diberikan gereja masa kini terhadap pandangan teologi feminis.