bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reseña: Cruce de miradas: Nuevas aproximaciones al libro-álbum
Authors: Munita Jordán Felipe 
Published: November 2018

ResumenCruce de miradas: Nuevas aproximaciones al libro-álbum revisa el estado actual de la investigación internacional sobre álbumes ilustrados, con un total de dieciséis artículos escritos por académicos e investigadores de reconocida trayectoria en este campo. El volumen se articula en 3 líneas temáticas: los libros-álbum y la cultura actual, la construcción narrativa del álbum y los retos cognitivos y la búsqueda de significado en la lectura de álbumes. ResumCruce de miradas: Nuevas aproximaciones al libro-álbum revisa l'estat actual de la recerca internacional sobre àlbums il?lustrats, amb un total de setze articles escrits per acadèmics i investigadors de reconeguda trajectòria en aquest camp. El volum s'articula en 3 línies temàtiques: els llibres- àlbum i la cultura actual, la construcció narrativa de l'àlbum i els reptes cognitius i la recerca de significat en la lectura d'àlbums.RésuméCruce de miradas: Nuevas aproximaciones al libro-álbum en revue l'état actuel de la recherche internationale sur les livres d'images, avec un total de seize articles écrits par des professeurs et des chercheurs de renom dans ce domaine. Le volume est divisé en trois thèmes: l'album et la culture moderne, la construction narrative de l'album et des difficultés cognitives et la recherche de sens dans la lecture d'albums.
No sé qué day: Code-switching and code-mixing in a plurilingual family living in Catalonia
Authors: Simon Auerbach Jill 
Published: November 2018

This study analyzes the unique plurilingual (Catalan, Spanish and English) speech of a family living in Catalonia in order to understand the variety of forms in which linguistic multicompetence is made manifest in their dialogues.. Factors that were found to influence code-switching and code-mixing in dialogues among family members include: the context of the conversation, the expression of distinct discursive voices, the affective consequences of employing the dominant or non-dominant language of the interlocutor, the ingrained nature of discourse markers, resistance to changing the names of academic concepts or courses, and the desire to creatively combine elements of distinct language systems to suit the expressive needs of the speaker. An argument is made in favor of a distinction being made between linguistic variety and communicative code as well as for a user-based, pragmatic view of language knowledge.
Teachers’ First Language Use in Second Language Learning Classroom Context: A Questionnaire-based Study
Authors: Mohebbi Hassan , Alavi Sayyed Mohammad 
Published: November 2018

Recently the issue of having recourse to second language (L2) learners’ first language (L1) in second language acquisition (SLA) is receiving a great amount of attention in SLA research. There has been a great deal of claims and counter-claims with respect to L1 use in L2 learning. The findings of L2 research to date cast doubt on the rationales of proponents of exclusive use of L2. Researchers and practitioners who have observed L2 classrooms have identified different functions of L1 in L2 learning. Drawing on previous research as a framework, the present study investigates teachers’ beliefs and perceptions about L1 use in English-as-a-foreign language (EFL) learning contexts. To this end, seventy-two L2 teachers volunteered to fill in a questionnaire which probed into their beliefs and perceptions about employing learners’ L1 (Persian) in L2 (English) learning. The data obtained revealed that the L2 teachers used L1 mainly to provide feedback, teach new vocabulary, explain grammar, build rapport, manage the class, give individual help to learners, and save time in lengthy task explanations. However, in contrast to the L2 studies to date in this field, the teachers expressed that they never fall back on learners’ L1 to explain instructions for assignments or projects. The findings might have significant implications for language teachers, in particular in EFL contexts, regarding the facilitative effects of L1 use on L2 learning. The pedagogical implications of the study are explained in detail.
L’ensenyament de l’espai geogràfic en una aula d’anglès de primària
Authors: Anguera Cerarols Carles 
Published: November 2018

El treball per competències posa l’èmfasi en què l’aprenentatge ha de suposar que l’alumnat sigui capaç dominar els recursos que el permetin actuar d’una forma eficaç i raonada en la societat actual. L’assoliment i adquisició d’aquestes competències implica conèixer, a nivell oral i escrit, aquelles llengües, que són imprescindibles per poder resoldre les situacions amb què les persones ens podem trobar en el desenvolupament de les nostres activitats socials com a ciutadans. El projecte PADS parteix d’aquestes premisses i presenta un treball que ha permès, entre d’altres coses, una aproximació a l’aprenentatge l’espai geogràfic en una aula d’anglès a primer curs de primària. Per fer-ho possible, s’ha recoltzat en metodologies com el treball per projectes i la telecol·laboració, fet que ha permès que l’aprenentatge hagi estat significatiu, funcional, transdisciplinar i competencial.
First occurrence of the enigmatic peccariesMylohyus elmoreiandProsthennops serusfrom the Appalachians: latest Hemphillian to Early Blancan of Gray Fossil Site, Tennessee
Authors: Doughty Evan M. , Wallace Steven C. , Schubert Blaine W. , Lyon Lauren M. 
Published: November 2018

Two peccary species,Mylohyus elmoreiandProsthennops serusare described from the medium-bodied fauna of the Gray Fossil Site (GFS) of northeastern Tennessee. This site, recognized as an oak-hickory forest, is latest Hemphillian or earliest Blancan based on mammalian biochronology, with an estimated age of 4.9–4.5 Ma. The GFS represents the only site outside the Palmetto Fauna of Florida withM. elmorei, greatly expanding the species range north over 920 km, well into the Appalachian region. This is also the first Appalachian occurrence of the relatively widespreadP. serus. Our understanding of intraspecific variation for bothM.elmoreiandP.serusis expanded due to morphological and proportional differences found in cranial and dental material from the GFS, Tyner Farm locality, Palmetto Fauna, and within the literature. The GFSM. elmoreimaterial represents the most complete mandible and second cranium for the species, and preserve intraspecific variation in the length of the diastema, dental proportions, and the complexity of the cuspules of the hypoconulid complex. Similarly, mandibular material from the GFS forP. serusexhibited larger dentitions and a greater degree of robustness than currently recognized for the species.
2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis
Authors: Singh Jasvinder A. , Guyatt Gordon , Ogdie Alexis , Gladman Dafna D. , Deal Chad , Deodhar Atul , Dubreuil Maureen , Dunham Jonathan , Husni M. Elaine , Kenny Sarah , Kwan‐Morley Jennifer , Lin Janice , Marchetta Paula , Mease Philip J. , Merola Joseph F. , Miner Julie , Ritchlin Christopher T. , Siaton Bernadette , Smith Benjamin J. , Van Voorhees Abby S. , Jonsson Anna Helena , Shah Amit Aakash , Sullivan Nancy , Turgunbaev Marat , Coates Laura C. , Gottlieb Alice , Magrey Marina , Nowell W. Benjamin , Orbai Ana‐Maria , Reddy Soumya M. , Scher Jose U. , Siegel Evan , Siegel Michael , Walsh Jessica A. , Turner Amy S. , Reston James 
Published: November 2018

ObjectiveTo develop an evidence‐based guideline for the pharmacologic and nonpharmacologic treatment of psoriatic arthritis (PsA), as a collaboration between the American College of Rheumatology (ACR) and the National Psoriasis Foundation (NPF).MethodsWe identified critical outcomes in PsA and clinically relevant PICO (population/intervention/comparator/outcomes) questions. A Literature Review Team performed a systematic literature review to summarize evidence supporting the benefits and harms of available pharmacologic and nonpharmacologic therapies for PsA. GRADE (Grading of Recommendations Assessment, Development and Evaluation) methodology was used to rate the quality of the evidence. A voting panel, including rheumatologists, dermatologists, other health professionals, and patients, achieved consensus on the direction and the strength of the recommendations.ResultsThe guideline covers the management of active PsA in patients who are treatment‐naive and those who continue to have active PsA despite treatment, and addresses the use of oral small molecules, tumor necrosis factor inhibitors, interleukin‐12/23 inhibitors (IL‐12/23i), IL‐17 inhibitors, CTLA4‐Ig (abatacept), and a JAK inhibitor (tofacitinib). We also developed recommendations for psoriatic spondylitis, predominant enthesitis, and treatment in the presence of concomitant inflammatory bowel disease, diabetes, or serious infections. We formulated recommendations for a treat‐to‐target strategy, vaccinations, and nonpharmacologic therapies. Six percent of the recommendations were strong and 94% conditional, indicating the importance of active discussion between the health care provider and the patient to choose the optimal treatment.ConclusionThe 2018 ACR/NPF PsA guideline serves as a tool for health care providers and patients in the selection of appropriate therapy in common clinical scenarios. Best treatment decisions consider each individual patient situation. The guideline is not meant to be proscriptive and should not be used to limit treatment options for patients with PsA.
Functionalized Holmium‐Doped Hollow Silica Nanospheres for Combined Sonodynamic and Hypoxia‐Activated Therapy
Authors: Wang Yanke , Liu Yan , Wu Huixia , Zhang Jianping , Tian Qiwei , Yang Shiping 
Published: November 2018

AbstractThe oxygen concentration dependence of sonodynamic therapy (SDT) and bioreductive therapy can be utilized to design the strategy of synergistic therapy. Herein, holmium‐doped hollow silica nanospheres are synthesized and then sequentially modified with chlorin e6, carboxyl poly(ethylene glycol) silane, and prostate stem cell antigen (PSCA) monoclonal antibody. The resultant nanocomposite designated as HHSN‐C/P‐mAb has good biocompatibility and can specifically target cancer cells overexpressing PSCA. Due to the inner cavity structure and Ho doping, HHSN‐C/P‐mAb shows high ultrasound (US) imaging contrast capability and excellent high‐field magnetic resonance contrast performance. HHSN‐C/P‐mAb can act as a nanocarrier for loading the bioreductive pro‐drug tirapazamine (TPZ), and the degradation of the hollow nanospheres under the trigger of acidic microenvironment favors the pH responsive release of TPZ from the material. Upon US irradiation, HHSN‐C/P‐mAb produces reactive oxygen species to kill the cancer cells, and importantly, the oxygen consumption during SDT induces an intratumoral hypoxic environment to activate the therapeutic function of codelivered TPZ, resulting in a high‐effective synergistic therapy. The findings of this study highlight that HHSN‐C/P‐mAb is a versatile theranostic nanoplatform for efficient cancer treatment.
Cadmium Sulfide Quantum‐Dot‐Photocatalyzed Cascade Cyclization of Functionalized Difluoromethyl Chlorides with Unactivated Olefins
Authors: Hu Jinglin , Pu Tong‐Jun , Xu Zhuo‐Wei , Xu Wen‐Yi , Feng Yi‐Si 
Published: November 2018

AbstractA cadmium sulfide quantum‐dot‐photocatalyzed C(sp3)−Cl bond cleavage of ethyl chlorodifluoroacetate and cascade cyclization with unactivated olefins is described herein. This reaction provides a cost‐efficient method for synthesizing a wide range of CF2‐containing azaheterocycles from a variety of functionalized difluoromethyl chlorides. Furthermore, the results of a preliminary anti‐proliferative activity study indicate an in vitro anti‐proliferative activity superior to that of doxorubicin with IC50 values of 1.140 μM on triple negative breast cancer (MDA‐MB‐231) and 2.129 μM on lung (A549) carcinoma cells.magnified image
Regiodivergent Control in the Gold(I) Catalyzed Synthesis of 7‐Pyrazolylindoles from 1‐Propargyl‐1H‐benzotriazoles and Ynamides through α‐Imino Gold(I) Carbene Complexes
Authors: Allegue Darío , González Jairo , Fernández Sergio , Santamaría Javier , Ballesteros Alfredo 
Published: November 2018

AbstractA smooth, gold catalyzed, atom‐economical and regioselective synthesis of indoles is reported here. The reaction occurs from a nucleophilic attack of in situ synthesized triazapentalenes to gold activated ynamides and involves the participation of α‐imino gold carbene complexes. The use of sulfonyl ynamides drives the reaction to the formation of 2‐amidosubstituted indoles. However, the employment of 2‐oxazolidinolylynamides allows the formation of both isomers, such as, 2‐amido‐ and 3‐amidosubstituted indoles. In this case, the regioselection could be controlled by a correct choice of the catalyst ligand and the electron‐donating capability of the aryl substituent of the ynamide. A correct control in both parameters permits a totally regioselective synthesis of one or the other regioisomer. Isolation of key intermediates and X‐ray analysis allowed for a plausible explanation for this behavior.magnified image
2D Nitrogen‐Containing Carbon Material C5N as Potential Host Material for Lithium Polysulfides: A First‐Principles Study
Authors: Wang Dandan , Li Haibo , Zhang Liangliang , Sun Zhonghui , Han DongXue , Niu Li , Zhao Jialong 
Published: November 2018

AbstractTwo‐dimensional (2D) materials are identified to be efficient in many applications. In this work, a novel 2D nitrogen‐containing carbon material, C5N, is theoretically designed through structure changes in atomic scale, that is, introducing VC–VN bivacancy defects along lines in perfect C3N monolayer. C5N monolayer is verified to be chemically, mechanically, dynamically, and thermodynamically stable based on cohesive energy, elastic constants, phonon spectrum, and molecular dynamics calculations. C5N is determined to be metallic which is an important property for battery electrode. Moreover, the anchoring performance of S8 and Li2Sn (n = 1, 2, 4, 6, and 8) on C5N monolayer and the anchoring mechanisms are explored. The adsorption energies are calculated to be −0.24, −1.20, −1.10, −1.06, −1.63, and −1.59 eV for S8, Li2S8, Li2S6, Li2S4, Li2S2, and Li2S, respectively. The anchoring effect of Li2Sn on C5N monolayer originates from the charge transfer between lithium polysulfides and C5N surface. These results reveal that C5N monolayer is a promising host material for polysulfides in Li–S batteries. Our calculations illustrate the design of nanostructures and facilitate the application of carbon‐based 2D materials in environment and energy.
Enhanced Switching Stability in Forming‐Free SiNx Resistive Random Access Memory Devices with Low Power Consumptions Based on Local Pt Doping in a Stacked Structure
Authors: Jiang Peng Fei , Gao Hai Xia , Yang Mei , Zhang Zhen Fei , Ma Xiao Hua , Yang Yin Tang 
Published: November 2018

AbstractIn this study, forming‐free and reliable resistive switching characteristics are demonstrated by using Pt doping in a stacked structure of SiNx resistive random access memory cells. Pt nanoparticles are embedded in situ and the size of them are about 1–2 nm. It ensures the potential of size scaling for the devices. Compared to those without Pt doping, a more reliable switching stability with better endurance and retention characteristics is obtained. The operating voltages and currents are low so that it is suitable for low power consumption applications. Films deposited at higher temperature show better compactness.
Surface State‐Mediated Charge Transfer of Cs2SnI6 and Its Application in Dye‐Sensitized Solar Cells
Authors: Shin HyeonOh , Kim Byung‐Man , Jang Taehyung , Kim Kwang Min , Roh Deok‐Ho , Nam Jung Seung , Kim Jeong Soo , Kim Un‐Young , Lee Byunghong , Pang Yoonsoo , Kwon Tae‐Hyuk 
Published: November 2018

AbstractA vacancy‐ordered double perovskite, Cs2SnI6, has emerged as a promising lead‐free perovskite in the optoelectronic field. However, the charge transfer kinetics mediated by its surface state remains unclear. Here, the charge transfer mechanism of Cs2SnI6 is reported and the role of its surface state in the presence of a redox mediator is clarified. Specifically, charge transfer through the surface state of Cs2SnI6 and its subsequent surface state charging are demonstrated by cyclic voltammetry and Mott–Schottky measurements, respectively. Because it is expected that the surface state of Cs2SnI6 is capable of regenerating oxidized organic dyes, a Cs2SnI6‐based regenerator is developed for a dye‐sensitized solar cell composed of fluorine‐doped tin oxide (FTO)/dyed mesoporous TiO2/regenerator/poly(3,4‐ethylenedioxythiophene)/FTO. As expected, the performance of the Cs2SnI6‐based regenerator is strongly dependent on the highest occupied molecular orbital of the dyes. Consequently, Cs2SnI6 shows efficient charge transfer with a thermodynamically favorable charge acceptor level, achieving a 79% enhancement in the photocurrent density (14.1 mA cm−2) compared with that of a conventional liquid electrolyte (7.9 mA cm−2). The results suggest that the surface state of Cs2SnI6 is the main charge transfer pathway in the presence of a redox mediator and should be considered in future designs of Cs2SnI6‐based devices.
Factors associated with medication adherence in older patients: A systematic review
Authors: Smaje Ashley , Weston‐Clark Maryse , Raj Ranjana , Orlu Mine , Davis Daniel , Rawle Mark 
Published: November 2018

AbstractObjectiveMedication adherence is a major challenge in the treatment of older patients; however, they are under‐represented in research. We undertook a systematic review focused on older patients to assess the reasons underlying non‐adherence in this population.MethodsWe searched multiple electronic databases for studies reporting reasons for non‐adherence to medication regimens in patients aged 75 years and over. Our results were not limited to specific diseases, health‐care settings, or geographical locations. The quality of eligible studies was assessed using the Newcastle‐Ottawa Scale. A narrative synthesis of findings was performed.ResultsA total of 25 publications were included, all of which were in community settings. Frequent medication review and knowledge regarding the purpose of the medication were positively associated with adherence. Factors associated with poor adherence were multimorbidity, cognitive impairment, complex regimens with multiple prescribing physicians, and problems with drug storage or formulation.ConclusionThese findings suggest that interventions to improve adherence could focus on medication review aimed at simplifying regimens and educating patients about their treatment. Groups with poor adherence that may benefit most from such a model include patients with multiple comorbidities and cognitive impairment.
Probing Hyperconjugative Aromaticity of Monosubstituted Cyclopentadienes
Authors: Xie Qiong , Sun Tingting , Orozco‐Ic Mesías , Barroso Jorge , Zhao Yu , Merino Gabriel , Zhu Jun 
Published: November 2018

AbstractHyperconjugation and aromaticity are two of the most important concepts in chemistry. Mulliken and co‐workers combined both terms to explain the stability of cyclopentadiene. Here, we carried out DFT calculations on a series of mono‐ and disubstituted cyclopentadiene derivatives to investigate their hyperconjugative aromaticity. Our results revealed that one electropositive substituent can induce aromaticity, whereas one electronegative substituent prompts nonaromaticity rather than antiaromaticity. When an electronegative substituent and a transition metal as an electropositive substituent were considered simultaneously, a slightly aromatic cyclopentadiene ring could be achieved, whereas an electropositive substituent of the main group in combination with an electronegative one will produce a nonaromatic cyclopentadiene ring.
Antioxidant Grain Passivation for Air‐Stable Tin‐Based Perovskite Solar Cells
Authors: Tai Qidong , Guo Xuyun , Tang Guanqi , You Peng , Ng Tsz‐Wai , Shen Dong , Cao Jiupeng , Liu Chun‐Ki , Wang Naixiang , Zhu Ye , Lee Chun‐Sing , Yan Feng 
Published: November 2018

AbstractTin‐based perovskites with excellent optoelectronic properties and suitable band gaps are promising candidates for the preparation of efficient lead‐free perovskite solar cells (PSCs). However, it is challenging to prepare highly stable and efficient tin‐based PSCs because Sn2+ in perovskites can be easily oxidized to Sn4+ upon air exposure. Here we report the fabrication of air‐stable FASnI3 solar cells by introducing hydroxybenzene sulfonic acid or its salt as an antioxidant additive into the perovskite precursor solution along with excess SnCl2. The interaction between the sulfonate group and the Sn2+ ion enables the in situ encapsulation of the perovskite grains with a SnCl2–additive complex layer, which results in greatly enhanced oxidation stability of the perovskite film. The corresponding PSCs are able to maintain 80 % of the efficiency over 500 h upon air exposure without encapsulation, which is over ten times longer than the best result reported previously. Our results suggest a possible strategy for the future design of efficient and stable tin‐based PSCs.
Late‐Stage Peptide Diversification through Cobalt‐Catalyzed C−H Activation: Sequential Multicatalysis for Stapled Peptides
Authors: Lorion Mélanie M. , Kaplaneris Nikolaos , Son Jongwoo , Kuniyil Rositha , Ackermann Lutz 
Published: November 2018

AbstractBioorthogonal late‐stage diversification of structurally complex peptides has enormous potential for drug discovery and molecular imaging. In recent years, transition‐metal‐catalyzed C−H activation has emerged as an increasingly viable tool for peptide modification. Despite major accomplishments, these strategies largely rely on expensive palladium catalysts. We herein report an unprecedented cobalt(III)‐catalyzed peptide C−H activation, which enables the direct C−H functionalization of structurally complex peptides, and sets the stage for a multicatalytic C−H activation/alkene metathesis/hydrogenation strategy for the assembly of novel cyclic peptides.
Optical Chirality Sensing with an Auxiliary‐Free Earth‐Abundant Cobalt Probe
Authors: De los Santos Zeus A. , Lynch Ciarán C. , Wolf Christian 
Published: November 2018

AbstractBroadly useful chiroptical enantiomeric excess (ee) sensing remains challenging and typically involves carefully designed molecular receptors or supramolecular assemblies. Herein, we report on the enantioselective sensing of 35 amino acids, amino phosphonic acids, hydroxy acids, amino alcohols, and diamines with an auxiliary‐free cobalt probe. Chiroptical analysis of the enantiomeric composition and concentration of minute sample amounts was achieved with high accuracy by using earth‐abundant cobalt salts and hydrogen peroxide as the oxidant. Despite the absence of an auxiliary ligand, the cobalt assay is applicable to aromatic and aliphatic compounds and yields strong CD signals at high wavelengths. This method obviates the general prerequisite for chromophoric metal ligands to generate chiroptical signals through ECCD (exciton‐coupled circular dichroism) effects or through analyte‐to‐ligand chirality induction, and it offers operational simplicity, cost efficiency, waste reduction, and speed.