bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ureteric Bud Cells Programmed from Embryonic Stem Cells Obtain Competence for Secondary Induction in the Kidney
Authors: Tan Zenglai , Rak-Raszewska Aleksandra , Skovorodkin Ilya , Vainio Seppo J. 
Published: August 2019

SUMMARYGeneration of kidney organoids from pluripotent stem cells (PSCs) is regarded as a potentially powerful way to study kidney development, disease, and regeneration. Direct differentiation of PSCs towards renal lineages is well studied, however, most of the studies relates to generation of nephron progenitor population from PSCs. Until now, differentiation of PSCs into ureteric bud (UB) progenitor cells demonstrates limited success. Here, we describe a simple, efficient and reproductive protocol to direct differentiation of mouse embryonic stem cells (mESCs) into UB progenitor cells. The mESC–derived UB cells were able to induce nephrogenesis when placed in the interaction with the primary metanephric mesenchyme (pMM). In generated kidney organoids, the embryonic pMM developed nephron structures and the mESC-derived UB cells formed network of collecting ducts, connected with the nephron tubules. Altogether, our studies established an uncomplicated and reproducible platform for kidney disease modelling, drug testing and regenerative medicine applications.
Acoustic contamination of electrophysiological brain signals during speech production and sound perception
Authors: Roussel Philémon , Godais Gaël Le , Bocquelet Florent , Palma Marie , Hongjie Jiang , Zhang Shaomin , Kahane Philippe , Chabardès Stéphan , Yvert Blaise 
Published: August 2019

AbstractA current challenge of neurotechnologies is the development of speech brain-computer interfaces to restore communication in people unable to speak. To achieve a proof of concept of such system, neural activity of patients implanted for clinical reasons can be recorded while they speak. Using such simultaneously recorded audio and neural data, decoders can be built to predict speech features using features extracted from brain signals. A typical neural feature is the spectral power of field potentials in the high-gamma frequency band (between 70 and 200 Hz), a range that happens to overlap the fundamental frequency of speech. Here, we analyzed human electrocorticographic (ECoG) and intracortical recordings during speech production and perception as well as rat microelectrocorticographic (µ-ECoG) recordings during sound perception. We observed that electrophysiological signals, recorded with different recording setups, often contain spectrotemporal features highly correlated with those of the sound, especially within the high-gamma band. The characteristics of these correlated spectrotemporal features support a contamination of electrophysiological recordings by sound. In a recording showing high contamination, using neural features within the high-gamma frequency band dramatically increased the performance of linear decoding of acoustic speech features, while such improvement was very limited for another recording showing weak contamination. Further analysis and in vitro replication suggest that the contamination is caused by a mechanical action of the sound waves onto the cables and connectors along the recording chain, transforming sound vibrations into an undesired electrical noise that contaminates the biopotential measurements. This study does not question the existence of relevant physiological neural information underlying speech production or sound perception in the high-gamma frequency band, but alerts on the fact that care should be taken to evaluate and eliminate any possible acoustic contamination of neural signals in order to investigate the cortical dynamics of these processes.
Individuation of parts of a single object and multiple distinct objects relies on a common neural mechanism in inferior intraparietal sulcus
Authors: Wurm Moritz F. , Porter Katharine B. , Caramazza Alfonso 
Published: August 2019

AbstractObject identification and enumeration rely on the ability to distinguish, or individuate, objects from the background. Does multiple object individuation operate only over bounded, separable objects or does it operate equally over connected features within a single object? While previous fMRI experiments suggest that connectedness affects the processing and enumeration of objects, recent behavioral and EEG studies demonstrated that parallel individuation occurs over both object parts and distinct objects. However, it is unclear whether individuation of object parts and distinct objects relies on a common or independent neural mechanisms. Using fMRI-based multivariate pattern analyses, we here demonstrate that activity patterns in inferior and superior intraparietal sulci (IPS) encode numerosity independently of whether the individuated items are connected parts of a single object or distinct objects. Lateral occipital cortex is more sensitive to perceptual aspects of the two stimulus types and the targets of the stimuli, suggesting a dissociation between ventral and dorsal areas in representing perceptual object properties and more general information about numerosity, respectively. Our results suggest that objecthood is not a necessary prerequisite for parallel individuation in IPS. Rather, our results point toward a common individuation mechanism that selects targets over a flexible object hierarchy, independently of whether the targets are distinct separable objects or parts of a single object.
Internalizing cooperative norms in group-structured populations
Authors: Akçay Erol , Van Cleve Jeremy 
Published: August 2019

AbstractSocial norms play a crucial role in human behavior, especially in maintaining cooperation within human social groups. Social norms might be self-enforcing or be enforced by the threat of punishment. In many cases, however, social norms are internalized and individuals have intrinsic motivations to observe norms. Here, we present a model for how intrinsic preferences to adhere to cooperative norms can evolve with and without external enforcement of compliance. Using the methodology of preference evolution, we model how cooperative norms coevolve with the intrinsic motivations to follow them. We model intrinsic motivations as being provided by guilt, a kind of internal “punishment” that individuals feel for falling short of cooperative norms, and show that the shape of this internal punishment function plays a crucial role in determining whether and how much internalization can evolve. We find that internal punishment functions that eventually level off with the deviation from the norm can support internalization without external punishment. In contrast, internal punishment functions that keep escalating with the deviation from the norm require external punishment, but yield stronger norms and more cooperation when external punishment is present. By showing how different preference mechanisms can enhance or limit norms that stabilize cooperation, these results provide insights into how our species might have evolved the norm psychology that helps us maintain such complex social and cultural institutions.
Autophagy controls lipid droplet formation by fine-tuning NCoR1 levels
Authors: Takahashi Shun-saku , Sou Yu-Shin , Saito Tetsuya , Kuma Akiko , Yabe Takayuki , Koike Masato , Terai Shuji , Mizushima Noboru , Waguri Satoshi , Komatsu Masaaki 
Published: August 2019

AbstractLipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, such as following a meal. LDs serve as an energy reservoir during fasting and have a buffering capacity that prevents lipotoxicity. Autophagy and the autophagic machinery have been proposed to play a role in LD biogenesis but the underlying molecular mechanism remains unclear. Here, we show that when nuclear receptor co-repressor 1 (NCoR1), which inhibits the transactivation of nuclear receptors, accumulates due to autophagy suppression, LD biogenesis is blocked. Ablation of ATG7, a gene essential for autophagy, suppressed the expression of gene targets of liver X receptor α (LXRα), a nuclear receptor responsible for fatty acid and triglyceride synthesis in an NCoR1-dependent manner. LD biogenesis in response to fasting and after hepatectomy was hampered by the suppression of autophagy. These results indicate that autophagy controls physiological hepatosteatosis by fine-tuning NCoR1 protein levels.
Otherness and closeness: residential tourism and rural gentrification processes
Authors: di Campli Antonio 
Published: August 2019

Purpose
This essay looks at how various forms of residential tourism or lifestyle migration, produced by people arriving from the cities and territories of the so-called Global North, have triggered complex processes of social-spatial modification in the landscapes and rural environments of Vilcabamba, Ecuador, a small Andean village of approximately 5,000 inhabitants in the southern part of the canton of Loja. The paper aims to discuss this issue.

Design/methodology/approach
Residential tourism in rural areas is a phenomenon that can be investigated by combining socio-economic studies with spatial analyses to define the specific characteristics of territories and environments affected by this phenomenon. In the case of Vilcabamba, the relationships and conflicts between imaginations, spaces, ecologies and desires have taken the form of a complex “implicit project”, a “palimpsest-project” intended as a set of territorial descriptions, interpretations and transformation actions triggered by a plot featuring migrant tourists, activists, eco-institutions, schools, artisans, intellectuals and artists. Though weakly connected to one another, these subjects nonetheless produce substantially coherent actions.

Findings
Two main hypotheses are given as: the first is that in particular rural contexts, such as the Andean area around Vilcabamba, dwelling practices and economies related to residential tourism have triggered processes through which these areas have progressively become peripheries to distant metropolitan territories and are reconfigured as sets of specialised places. The second hypothesis is that Vilcabamba and its rural surroundings can be viewed as a particular “contact zone” in which different types of residential tourists and local dwellers interact, together with different economies of tourism. In this case the reference is, on the one hand, to the logics and discourses of the so-called extractive tourism, a concept that describes the processes of “extracting” and converting local cultural characteristics, and “indigenousness”. To support these hypotheses, the result is the construction of a spatial representation of the ways in which specific practices of residential tourism are territorialised, and how they modify the meaning and functioning of rural spaces.

Originality/value
What is new in the paper is the attempt to define a spatial representation of transnational spaces trying to highlight relationships between extractive tourism and remittance urbanism.
Domestic demand-based economic globalization and inclusive growth
Authors: Zheng Jianghuai , Shen Chunmiao 
Published: August 2019

Purpose
The purpose of this paper is to propose policy recommendations that resort to the domestic market to achieve inclusive growth from an open perspective.

Design/methodology/approach
How will economic globalization based on domestic demand affect economic growth and income distribution in an open and large country? With the aim of discussing the mechanism of the impact of expanding domestic demand on the inclusive growth from an open perspective, this paper incorporates the Global Value Chains vs National Value Chains (GVC-NVC) competition, which is triggered by foreign investments attracted by the domestic demand scale into an endogenous growth model with “Schumpeterian Innovation.”

Findings
Theoretical analysis indicates the following findings: although domestic demand-based economic globalization can promote transnational inclusive growth across countries, it is not conducive to national (domestic) inclusive growth; the impacting effect of domestic demand scale on inclusive growth across countries is subject to the moderating effect of the development maturity of the labor market; and the impacting effect of domestic demand scale on national inclusive growth is subject to the joint moderating effect of the development maturity of the labor market and labor skill structure.

Originality/value
First, this paper examines the impact of domestic demand-based economic globalization on the inclusiveness of economic growth from an open perspective, which deepens the existing theory of intra-product specialization and inclusive growth. Second, the paper puts the sequential production process into Schumpeterian growth model and reveals the mechanism that domestic demand affects inclusive growth. Third, the study finds that the enhancement of labor market efficiency, transfer payments to low-skilled labor and the creation of a fair competitive market environment will contribute to the globalization of a domestic demand-oriented economy, which provides a policy-making basis for government sectors.
Hide and seek: evasion and search as FDI motivation
Authors: Burmester Brent , Scott-Kennel Joanna 
Published: August 2019

PurposeThe purpose of this paper is to argue for inclusion of evasive foreign direct investment (FDI) into search-based motivation typologies in international business.Design/methodology/approachCritically reassessing academic literature and using anecdotal evidence, the authors augment the theory of FDI motivation with the concept of evasion.FindingsEvasive FDI is a firm-level response to denial-of-privilege by a state. Divergence of policy environments between home and host prompts relocation or international expansion of productive assets and often the affectation of ‘foreignness’ by the multinational enterprise (MNE). The role of responsibility evasion via FDI is understood in the research literature, mainly because of an emphasis on search-based motives and a failure to distinguish between escape and evasion. International business research is vulnerable to mis-identification of FDI motive which consequently distorts its strategic and policy implications.Originality/valueThe argument for inclusion of evasive FDI serves to augment the established, yet asymmetrically focussed typology of search FDI, demonstrating that evasion is conceptually and analytically distinguishable from search. Further, an augmented typology lends accuracy and insight to research into the reconfiguration strategies of MNEs and legitimation of the international business discipline itself, providing researchers with a more comprehensive account of FDI causation and offering new research paths.
Projectification in Iceland measured – a comparison of two methods
Authors: Ingason Helgi Thor , Fridgeirsson Thordur V. , Jonasson Haukur Ingi 
Published: August 2019

Purpose
The purpose of this paper is to improve the methodology of assessing the importance of projects in a national economy. The subject of study is projectification in the Icelandic economy and to measure this, the share of project work in relation to the total work done in an organisation was used as an indicator. This is a time-consuming approach and it was decided to do an additional benchmark study, to verify the alleged importance of projects, and to investigate the usefulness of a benchmark study and establish whether the two approaches could complement each other.

Design/methodology/approach
Data were collected from 146 organisations in Iceland, regarding the share of project work relative to total work, as explained by Schoper et al. (2018). In addition, by participation in a large quarterly omnibus survey among people with high management positions in their respective companies in Iceland, more general data were collected. The methods and outcomes of both surveys were compared, and general conclusions are drawn.

Findings
The authors conclude that the two research approaches complement each other and could be applied in a systematic way to give a longitudinal view of the evolution of projectification in a society, where projectification is measured, traced over time and benchmarked. The first part is more complicated and expensive in execution, and could be done at longer intervals, whereas the second part takes less effort and can be used to monitor the evolution more regularly.

Originality/value
Two very different research approaches were applied to assess projectification. On the one hand, a detailed quantitative survey of the economic impact of projects. On the other hand, a general survey of a very large sample of managers. This combined approach to assess the level of projectification is new, and the authors hope that this will be of value in the context of developing efficient, reliable and practical methods to assess projectification of societies.
M&As in Africa – effects of law and governance
Authors: Lundqvist Alex , Liljeblom Eva , Löflund Anders , Maury Benjamin 
Published: August 2019

Purpose
The cultural and legal differences between foreign acquirers and African target firms can be substantial. There is also a large variation in cultures and legal systems within Africa. However, there is limited research on merger and acquisition (M&A) performance by foreign firms in Africa. The purpose of this paper is to fill this gap by exploring the “spillover by law” hypothesis (Martynova and Renneboog, 2008) that focuses on the influence of the external environment on the governance and performance of foreign M&As in Africa.

Design/methodology/approach
The data set covers 415 M&A transactions by foreign firms in Africa during the period of 1999–2016. Dynamic data covering the country’s legal, cultural and political environment are collected from the World Bank, the Heritage Foundation and Transparency International.

Findings
The authors find that the legal environment significantly affects the returns of bidders on African firms. For complete acquisitions, bidder returns are significantly higher when the bidder’s country has higher shareholder protection and higher creditor protection compared with the target firm’s country. The results show that the effects are significant when there is a full control change (including a change in the target firm’s nationality) but not in the case of partial control transfers. The results are consistent with the “spillover by law” hypothesis.

Originality/value
The authors contribute to the literature on cross-border M&As by separately studying the valuation effects of full, majority and minority changes in control; by being the first study of the legal spillover effects in Africa; and by being the most extensive study of the legal determinants of the valuations of non-African acquirers of African firms.
Reliability assessment on automobile suspension system using wavelet analysis
Authors: Abd Rahim Airee Afiq , Abdullah Shahrum , Singh Karam Singh Salvinder , Nuawi Mohd. Zaki 
Published: August 2019

Purpose
The purpose of this paper is to focus on the reliability assessment on the basis of automobile suspension fatigue life using wavelet decomposition method.

Design/methodology/approach
The discrete wavelet transform (DWT) of automobile coil spring signal is implemented as a response to different road surfaces. A reliability analysis is applied to determine the potential of the wavelet implementation in fatigue life analysis. The signals used in this study are highway and rural road.

Findings
On the basis of the implementation of wavelet decomposition method, low-level decomposition replicates the original signals in comparison with high-level decomposition. The fatigue life of low-level decomposition lies in the 2:1 and 1:2 correlation graph. The percentage difference for mean cycle to failure presents low values for low-level decomposition, with 44.31 per cent for highway and 44.20 per cent for rural road. The percentage of difference for high-level decomposition is high.

Originality/value
The determination of fatigue life analysis by using the DWT method is suitable for low-level decomposition. High-level decomposition is considered noise that cannot be eliminated and does not contribute to the failure of the structure.
Zeuss: a personalized tool for grammatical-construction learning
Authors: Mendoza Maria J. , Velasco David L. , Moreno Camilo A. , Parra Carlos , Carrillo-Ramos Angela , Gómez-Morantes Juan E. 
Published: August 2019

Purpose
The purpose of this paper is to present Zeuss, a software-based tool designed to improve grammar learning process in elementary school children. Despite efforts by the Colombian Government, the results of the final high school test indicate that students have major deficiencies with language, grammar and reading comprehension. Several difficulties have been evidenced in activities like writing essays or understanding academic papers. Among the reasons that may lead to these results include outdated courses, overcrowded classrooms and lack of interest.

Design/methodology/approach
A diagnostic test is performed on third-grade elementary school students to assess the current grammar knowledge and identify areas for improvement. The test results are used to design a software-based tool called Zeuss. The authors include playful activities inspired by several pedagogic exercises found in the literature and personalization so that interaction is tailored to specific user preferences and tastes.

Findings
Zeuss has been tested with third-grade students of the Gimnasio Campestre San Francisco de Sales elementary school in Bogotá, Colombia. The results show that using the tool leads to an overall improvement in the grammar construction learning process.

Social implications
Zeuss aims at improving the learning process in elementary schools helping teachers to overcome several limitations like overcrowded classrooms and outdated pedagogic strategies. Zeuss focuses specifically on the grammar learning process.

Originality/value
Zeuss features updated pedagogical strategies, playful activities and a personalization model to tailor the learning process and help in context. It also allows teachers to track individual and classroom progress.