bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exposure to the RXR agonist SR11237 in early life causes disturbed skeletal morphogenesis in a rat model
Authors: Dupuis Holly , Pest Michael Andrew , Hadzic Ermina , Vo Thin Xuan , Hardy Daniel B. , Beier Frank 
Published: September 2019

AbstractLongitudinal bone growth occurs through endochondral ossification (EO), controlled by various signaling molecules. Retinoid X Receptor (RXR) is a nuclear receptor with important roles in cell death, development, and metabolism. However, little is known about its role in EO. In this study, the agonist SR11237 was used to evaluate RXR activation on EO.Rats given SR11237 from post-natal day 5 to 15 were harvested for micro-computed tomography scanning and histology. In parallel, newborn CD1 mouse tibiae were cultured with increasing concentrations of SR11237 for histological and whole mount evaluation.RXR agonist-treated rats were smaller than controls, and developed dysmorphia of the growth plate. Cells invading the calcified and dysmorphic growth plate appeared pre-hypertrophic in size and shape corresponding with P57 immunostaining. Additionally, SOX9 positive cells were found surrounding the calcified tissue. The epiphysis of SR11237 treated bones showed increased TRAP staining, and additional TUNEL staining at the osteo-chondral junction. MicroCT revealed morphological disorganization in the long bones of treated animals. Isolated mouse long bones treated with SR11237 grew significantly less than their DMSO controls.This study demonstrates that stimulation of the RXR receptor causes irregular ossification, premature closure of the growth plate, and disrupted long bone growth in rodent models.
Cas9-mediated gene-editing in the malaria mosquito Anopheles stephensi by ReMOT Control
Authors: Macias Vanessa M. , McKeand Sage , Chaverra-Rodriguez Duverney , Hughes Grant L. , Fazekas Aniko , Pujhari Sujit , Jasinskiene Nijole , James Anthony A. , Rasgon Jason L. 
Published: September 2019

AbstractInnovative tool development is essential for continued advancement in malaria control and depends on a deeper understanding of the molecular mechanisms that govern transmission of malaria parasites by Anopheles mosquitoes. Targeted disruption of genes in mosquito vectors is a powerful method to uncover the underlying biology of vector-pathogen interactions, and genome manipulation technologies can themselves form the basis of mosquito and pathogen control strategies. However, the embryo injection methods used to genetically manipulate mosquitoes, and in particular Anopheles species, are difficult and inefficient, particularly for non-specialist laboratories. We have adapted a strategy called ReMOT Control (Receptor-mediated Ovary Transduction of Cargo) to deliver the Cas9 ribonucleoprotein complex to adult mosquito ovaries and generate targeted and heritable mutations in the malaria vector Anopheles stephensi. We found that gene editing by ReMOT Control in Anopheles mosquitoes was comparable to the technique in Ae. aegypti and as efficient in editing as standard embryo injections. The adaptation of this technology to Anopheles mosquitoes opens up the power of reverse genetics to malaria vector labs that do not have the equipment or technical expertise to perform embryo injections and establishes the flexibility of ReMOT Control for gene-editing in non-Aedes species.
Exploring consumers’ willingness to eat insects in Italy
Authors: Palmieri Nadia , Perito Maria Angela , Macrì Maria Carmela , Lupi Claudio 
Published: September 2019

Purpose
The purpose of this paper is to investigate the main factors that may affect Italian consumers’ willingness to eat insects. Italy is a fairly special case among Western countries: in many Italian regions, there is old traditional food with insects.

Design/methodology/approach
Data come from a sample of 456 consumers living in four Italian regions. The empirical investigation involves several steps: modification of class distributions to obtain a balanced sample; model estimation using the least absolute shrinkage and selection operator; model evaluation using out-of-sample classification performance measures; and estimation of the “effect” of each explanatory variable via average predictive comparisons. The uncertainty associated with the whole procedure is evaluated using the bootstrap.

Findings
The interviewed consumers are generally unwilling to eat insect-based food. However, factors such as previous experience, taste expectations and attitude towards both new food experiences and sustainable food play an important role in shaping individual inclination towards eating insects.

Research limitations/implications
The sample analysed in this study is not representative of the whole national population, as it happens in most papers dealing with entomophagy.

Originality/value
The paper revisits the issue using a relatively large sample and sophisticated statistical methods. The likely average effect of each explanatory variable is estimated and discussed in detail. The results provide interesting insights on how to approach a hypothetical Italian consumer in view of the possible development of a new market for edible insects.
Unbundling dynamic capabilities for inter-organizational collaboration
Authors: Petricevic Olga , Verbeke Alain 
Published: September 2019

PurposeThe purpose of this paper is to explore two distinct subsets of dynamic capabilities that need to be deployed when pursuing innovation through inter-organizational activities, respectively, in the contexts of broad networks and specific alliances. The authors draw distinctions and explore potential interdependencies between these two dynamic capability reservoirs, by integrating concepts from the theoretical perspectives they are derived from, but which have until now largely ignored each other – the social network perspective and the dynamic capabilities view.Design/methodology/approachThe authors investigate nanotechnology-driven R&D activities in the 1995–2005 period for 76 publicly traded firms in the electronics and electrical equipment industry and in the chemicals and pharmaceuticals industry, that applied for 580 nanotechnology-related patents and engaged in 2,459 alliances during the observation period. The authors used zero-truncated Poisson regression as the estimation method.FindingsThe findings support conceptualizing dynamic capabilities as four distinct subsets, deployed for sensing or seizing purposes, and across the two different inter-organizational contexts. The findings also suggest potential synergies between these subsets of dynamic capabilities, with two subsets being more macro-oriented (i.e. sensing and seizing opportunities within networks) and the two other ones more micro-oriented (i.e. sensing and seizing opportunities within specific alliances).Practical implicationsThe authors show that firms differ in their subsets of dynamic capabilities for pursuing different types of inter-organizational, boundary-spanning relationships (such as alliances vs broader network relationships), which ultimately affects their innovation performance.Originality/valueThe authors contribute to the growing body of work on dynamic capabilities and firm-specific advantages by unbundling the dynamic capability subsets, and investigating their complex interdependencies for managing different types of inter-organizational linkages. The main new insight is that the “linear model” of generating more innovations through higher inter-firm collaboration in an emerging field paints an erroneous picture of how high innovation performance is actually achieved.
The role of felt obligation to mentor in mentor performance
Authors: Maynard-Patrick Stephanie , Baugh S. Gayle 
Published: September 2019

PurposeThe authors introduce a new measure of felt obligation to mentor in order to explore generalized reciprocity in mentoring. The purpose of this paper is to explore whether felt obligation to mentor adds prediction to mentor job performance in combination with mentoring functions provided and mentor-assessed benefits and costs of mentoring.Design/methodology/approachHypotheses were tested in a sample of firefighters in the Southwestern USA using moderated regression analysis.FindingsProtégé reported mentoring functions provided predicted mentor performance, but neither mentoring benefits nor costs predicted mentor performance. Felt obligation to mentor interacted with mentoring functions reported such that mentor performance was highest when both mentoring functions provided and felt obligation to mentor were high.Research limitations/implicationsThe results indicate that the new measure may prove to be of value for exploring generalized reciprocity in mentoring. Further, more research using mentoring benefits and costs is merited. Findings are limited by use of a new measure of felt obligation to mentor as well as the fact that the research was conducted in a setting in which employees were expected to serve as mentors.Practical implicationsOrganizations may leverage felt obligation to mentor in order to support effective informal or formal mentoring relationships, whereas focusing on the benefits of mentoring may be a less valuable strategy.Originality/valueThe research offers a new measure to help to understand generalized reciprocity as a motivation to mentor as well as suggesting that more empirical attention should be given to the perceived benefits and costs of mentoring.
Entry and exit affordability of shared equity homeownership: an international comparison
Authors: Cheung Ka Shing , Wong Siu Kei 
Published: September 2019

Purpose
Shared equity homeownership is a form of subsidised, resale-restricted housing through which lower-income households can sustain their affordability. This paper aims to distinguish two types of affordability within shared equity homeownership: “entry affordability” indicates how affordable subsidised housing is when a household first becomes a subsidised owner; while “exit affordability” means how affordable private housing is after a household has enjoyed subsidised homeownership for a period of time.

Design/methodology/approach
Using price-to-income ratios, this study compares the entry and exit affordability of shared equity homeownership programs in Australia, Mainland China, Hong Kong, Norway, the UK and the USA. Based on these international comparisons, this study generalises two distinct types of shared equity homeownership models, namely, the models of “share-to-buy” and “share forever”. A new model, “follow-as-you-go”, is further suggested to increase the elasticity of potential affordable housing supply by providing incentives for existing subsidised homeowners to move.

Findings
A key finding of this study is that while shared equity homeownership programs can improve entry affordability, homeowners’ exit affordability is weak when subsidised homeowners have to share their capital gain with the government. While many housing policy discussions around the world that support shared equity homeownership focus only on the improvement of entry affordability, these discussions usually ignore the importance of exit affordability. This study attempts to fill the void in the understanding of these two types of affordability.

Originality/value
Shared equity homeownership policy is not only about offering low-income households but also an affordable housing option. It is also about facilitating well-off subsidised homeowners to move up the housing ladder so that the affordable housing option can be freed up for others in need. In a word, it is not only entry affordability but also exit affordability that matters.
Determinants of bank shareholder value: evidence from GCC countries
Authors: Saif-Alyousfi Abdulazeez Y.H. 
Published: September 2019

Purpose
The purpose of this paper is to examine the effect of bank specific, financial structure and macroeconomic factors on the shareholder value of banks in GCC economies during 2000–2017.

Design/methodology/approach
To estimate the model and analyze the data collected from the BankScope and World Bank World Development Indicator database, the author uses static panel estimation techniques as well as two-step difference and system dynamic generalized method of moments estimator.

Findings
The results show that banks that are highly dependent on non-traditional activities have higher shareholder value. Higher opportunity cost, capitalization and demand deposits result in a better bank shareholder value. Furthermore, banks with higher loan exposure and growth have better shareholder value. Non-performing loans and market risk have insignificant effects on bank shareholder value. However, GCC banks suffer from diseconomies of scale and scope. The author also finds that banks located in countries with high inflation rates, high rates of interest or in financially developed economies offer better shareholder value. High credit to the private sector reduces the bank shareholder value. The paper also provides evidence that the impact of financial turmoil on the shareholder value of the GCC banking sector is negative and significant and has severely weakened the GCC banking system.

Practical implications
The results of this study necessitate formulation of various policy measures that can counter the effects of shareholder value of banks.

Originality/value
The present study is among the first to address the influence of financial turmoil on bank shareholder value. It also studies new variables, such as demand deposits, non-performing loans, loan growth, non-interest revenue and off-balance sheet activities, which have not been examined in relation to bank shareholder value. It also applies both static techniques and dynamic panel estimation techniques to analyze the data. The analysis is carried out at the aggregate level as well as at the national level and also provides several robustness analyses using various model specifications.
Economic analysis of using green accounting and environmental accounting to identify environmental costs and sustainability indicators
Authors: Rounaghi Mohammad Mahdi 
Published: September 2019

Purpose
Manufacturing and service companies are likely to make a variety of costs possible. Environmental costs are one of those costs. Environmental performance is one of the most important factors in assessing a company’s success. For environmental accounting, companies need to work together as teams of system designers, chemists, engineers, production managers, operators, employees, purchasing circle and accountants (those who may have never worked together before).

Design/methodology/approach
Nowadays, most of the companies are facing environmental issues and are seeking an appropriate way to report and disclose the information to the public. The environmental pollution issue is among the most important problems of today’s human society. Therefore, this is very important to use environmental accounting as an attempt towards protecting the environment.

Findings
Green accounting is a type of accounting that attempts to factor environmental costs into the financial results of operations. Apart from answering the question whether the economy has performed sustainably during one or more accounting periods, green accounting indicators [green gross domestic product (GDP)] can be used in policy formulation and evaluation. Green GDP calculations can contribute to raise awareness for sustainability concerns among national governments/policy-makers, who tend to concentrate on their countries’ fast economic development.

Practical implications
Environmental accounting can be applied to large and small companies in various industries, as well as in manufacturing or service sectors. Environmental accounting can be applied on a large or a smaller scale in a systematic manner for the required bases.

Social implications
Environmental accounting requires the collection of information from all the groups. People of various groups need to talk to each other to achieve a common vision and understanding of environmental accounting and to realize this vision.

Originality/value
Undoubtedly, to establish an ideal system of environmental accounting in the country, accountants can become a powerful forearm of the government regarding economical and financial controls. To achieve this goal, environmental accounting objectives and tasks should be identified and defined in detail, and the standards, rules and criteria should be grounded and codified based on reasonable and practical principles.
Service quality, perceived value and behavioral intentions among highly and lowly identified baseball consumers across nations
Authors: Ma Shang Chun , Kaplanidou Kyriaki 
Published: September 2019

Purpose
The purpose of this paper is to understand how team identification and country influence professional baseball team spectators’ evaluations of service quality factors, perceived value and future behavioral intentions.

Design/methodology/approach
Data were collected online from sports consumers of the Chinese Professional Baseball League (CPBL) in Taiwan (n = 600) and Major League Baseball in the USA (n = 460). A regression-based estimation method (PROCESS) and structural equation modeling approach were used to assess the relationships.

Findings
Both direct and indirect (via perceived value) effects of most service quality factors (schedule convenience, economic consideration, game amenities, ticket service and venue quality) on behavioral intentions are stronger for lowly than for highly identified CPBL fans. The indirect effect of home team on behavioral intentions is stronger for the lowly identified CPBL fans. The direct effect of game amenities and the indirect effect of venue quality (via perceived value) on behavioral intentions are stronger for the highly identified MLB fans. The indirect effect of opposing team and economic consideration is stronger for the lowly identified MLB fans. The positive relationship between venue quality and perceived value is stronger for the USA than for Taiwan fans. The relationships between game amenities and perceived value and between perceived value and behavioral intention are perceived to be invariant between fans from the two countries. Taiwan fans’ behavioral intentions tend to be directly and indirectly affected by service quality factors, whereas US fans’ behavioral intentions tend to be indirectly affected by service quality factors.

Originality/value
The study provides empirical evidence of the moderating role of team identification associated with the relationships between separate service quality factors, perceived value and behavioral intentions among consumers of a professional spectator sports in two different countries.
Alike but different: four ancient capitals in china and their destination images
Authors: Wang Fang , Lu Lijun , Xu Lu , Wu Bihu , Wu Ying 
Published: September 2019

Purpose
Tourists’ destination image is crucial for visiting intentions. An ancient capital with diverse characteristics is an important component of China’s urban tourism. The purpose of this paper is to address the following questions: what are the differences and commonalities of the perceived destination image of ancient capitals? What makes the difference of the perceived destination image in these cities? Aside from the exterior factors, are there internal factors of cities that influence tourists’ cognition and perception of destination image?

Design/methodology/approach
The comment text data of Baidu tourism website were used to determine the differences in the destination images of China’s four great ancient capitals: Beijing, Xi’an, Nanjing and Luoyang. ROST content mining and semantic network analysis were for differences and commonalities of the perceived destination image, and correlation analysis was used to explore the internal factors of cities that influence tourists’ cognition and perception of destination image.

Findings
Though the same as ancient capital, the four ancient capitals’ images are far apart; historical interests are the core of tourism experience in ancient capital city; image perception is from physical carrier, history and culture, and human cognition; tourist’ destination affect of ancient capital is most from its history and culture; protecting identity and maintaining daily life are crucial for ancient city tourism.

Originality/value
Previous studies on ancient capitals have focused on the invariable identity of ancient capitals’ destination images, and left a gap on determining from where the invariable identity comes in general and how much it influences destination image. This gap was addressed in this study, by analyzing the destination images of four ancient capitals in China as cases. In this way, this study provided reference to the other ancient cities worldwide.
Egypt’s perceived destination image and its impact on tourist’s future behavioural intentions
Authors: Ragab Hany , Mahrous Abeer A. , Ghoneim Ahmed 
Published: September 2019

Purpose
There is a substantial body of the literature on the role of destination image in tourist’s future behavior, however, the majority of these studies were conducted in “Sun-and-Sand” destinations, and only a few studies have addressed this research topic in “Historical-and-Cultural” destinations context. The purpose of this paper is to fill this gap by investigating the impact of Egypt’s perceived destination image – as one of the most famous cultural and historical destinations in the global tourism arena – and tourist satisfaction on tourists’ future behavioral intentions.

Design/methodology/approach
The study adopted a mixed methodology (a combination of survey questionnaire based on a quota sample from 400 tourists, as well as semi-structured interviews with tourists from different nationalities). Data were analyzed using exploratory factor analyses, confirmatory factor analysis and structural equation modeling.

Findings
The results related to the impact of the perceived destination image are discussed. Also, some practical implications related to destination management organizations are highlighted.

Originality/value
The study contributes theoretically and empirically to destination image literature, by improving the understanding of the multi-dimensional nature of destination image and its impact on revisit intention and word-of-mouth recommendation. Also, it helps in guiding Egypt’s destination image management activities to rebuild Egypt’s image as a safe destination for all the world’s travelers.
Principal normal stress cavitation criterion for CFD analysis of loading capacity in journal bearings
Authors: Li Qiang , Zhang Shuo , Wang Yujun , Xu Wei-Wei , Wang Zengli , Wang Zhenbo 
Published: September 2019

Purpose
Shear stresses have a considerable influence on the characteristics of lubricants and become significant at high rotating speeds. This study aims to investigate the influences of shear cavitation (SC) on loading capacity of journal bearings.

Design/methodology/approach
A principal normal stress cavitation criterion based on the stress applied to flowing lubricant in journal bearings is developed and used to investigate SC in journal bearings. A computational fluid dynamic (CFD) model for calculating the loading capacity is established using this criterion. After validation with experimental results, the loading capacity is calculated under different conditions.

Findings
The calculation results indicate that SC intensifies when viscosity, speed and eccentricity increase. Angle of loading capacity with SC is larger than that without SC. The magnitude of loading capacity with SC is smaller than that without SC due to the decrease in the ultimate pressure. In addition, the magnitude difference between the loading capacity with and without SC increases when viscosity, speed and eccentricity increases.

Originality/value
Present research can provide some guidance for calculating the loading capacity when a journal bearing is operating at high speed or with a high viscosity lubricant.