bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diffuse subretinal fibrosis syndrome: A rare entity
Authors: Stolowy Natacha D , Donnadieu Benjamin P , Comet Alban CM , Nadeau Sébastien , Beylerian Marie A-S , Denis Danièle , Matonti Frédéric J 
Published: May 2018

Background/ purpose: Diffuse subretinal fibrosis and uveitis syndrome is an inflammatory disease rarely reported. The purpose of this article is to describe a rare case of diffuse subretinal fibrosis syndrome in an 8-year-old child. Methods and results: The patient initially presented with a loss of vision in his right eye, with a visual acuity of 20/200. The visual acuity of the left eye was normal. Clinical examination showed bilateral anterior and posterior inflammation while the fundus revealed on the right eye an inter maculopapillar fibrosed lesion with a discrete retinal hemorrhage and a similar but smaller lesion on the left eye. The optical coherence tomography showed hyper-reflective material compatible with pre-retinal and subretinal pigment epithelial fibrosis and associated subretinal fluid. The angiography facilitated the diagnosis of neovascularization that was associated with the fibrotic lesion. The rest of the clinical pediatric examination remained negative and a diagnosis of diffuse subretinal fibrosis syndrome complicated with neovascularization was made. Treatment with systemic corticosteroids at the dose of 1 mg/kg/day for 1 month with a progressive decrease of 5 mg per month allowed for both anatomical and functional improvement. The visual acuity of the right eye improved from 20/200 to 20/63 at 1 month, 20/32 at 2 months, and 20/20 at 4 months. Conclusion: To our knowledge, this is the first reported case of bilateral diffuse subretinal fibrosis complicated by neovascularization. General corticosteroid therapy proved to be effective in this case and appears to be a viable option in first-line treatment.
The process of disclosing a diagnosis of dementia and mild cognitive impairment: A national survey of specialist physicians in Denmark
Authors: Nielsen T Rune , Svensson Birthe Hjorth , Rohr Gitte , Gottrup Hanne , Vestergaard Karsten , Høgh Peter , Waldemar Gunhild 
Published: May 2018

Background Although general recommendations for diagnostic disclosure of dementia are available, little is known about how these recommendations are implemented. The aim of the current study was to investigate the process and content of dementia diagnostic disclosure meetings, and to compare key aspects of disclosing a diagnosis of dementia and mild cognitive impairment. Method A total of 54 specialist physicians in Danish dementia diagnostic departments completed an online survey on their practices regarding diagnostic disclosure of dementia and mild cognitive impairment. The influence of respondent characteristics was assessed, and differences on key aspects of disclosing a diagnosis of dementia and mild cognitive impairment were analyzed. Results The results suggest that among Danish specialist physicians, there is a general consensus regarding the organization of diagnostic disclosure meetings. However, differences in employed terminology and information provided when disclosing a dementia diagnosis were evident. Significant differences were present on key aspects of the diagnostic disclosure of dementia and mild cognitive impairment. For instance, 91% would use the term dementia during diagnostic disclosures compared to just 72% for mild cognitive impairment. Conclusion The range of practices reflected in the present study confirms the complexity of diagnostic disclosure and highlights the importance of preparation and follow-up strategies to tailor the disclosure process to the needs of individual patients with dementia and their caregivers. Due to earlier diagnosis of neurodegenerative disorders, more research is urgently needed on this aspect of the diagnostic process, especially to develop evidence-based models for the disclosure of mild cognitive impairment.
Prevalence of Workplace Violence Against Health-Care Professionals in China: A Comprehensive Meta-Analysis of Observational Surveys
Authors: Lu Li , Dong Min , Wang Shi-Bin , Zhang Ling , Ng Chee H. , Ungvari Gabor S. , Li Jun , Xiang Yu-Tao 
Published: May 2018

Background: In China, workplace violence (WPV) toward health-care professionals has been a major concern, but no meta-analysis on this topic has been published. This study is a meta-analysis of the pooled prevalence of WPV against health-care professionals in China and its associated risk factors. Method: English- (PubMed, PsycINFO, and Embase) and Chinese-language (Chinese National Knowledge Infrastructure, WanFang, and SinoMed) databases were systematically searched. Data on the prevalence of WPV and the subtypes of violence experienced by health-care professionals in China were extracted and pooled using random-effects models. Findings: A total of 47 studies covering 81,771 health-care professionals were included in the analyses. The overall prevalence of WPV from 44 studies with available data was 62.4% (95% confidence interval [CI] = [59.4%, 65.5%]). The estimated prevalence of physical violence, psychological violence, verbal abuse, threats, and sexual harassment were 13.7% (95% CI [12.2%, 15.1%]), 50.8% (95% CI [46.2%, 55.5%]), 61.2% (95% CI [55.1%, 67.4%]), 39.4% (95% CI [33.4%, 45.4%]), and 6.3% (95% CI [5.3%, 7.4%]), respectively. Males were more likely to experience WPV than females. Interpretation: WPV against health-care professionals appears to be a significant issue in China. Relevant policies and procedures related to WPV should be developed. Staff should be provided with adequate training, education, and support to implement violence management policies to ensure safety at the workplace.
Dysfunctional Nav1.5 channels due to SCN5A mutations
Authors: Han Dan , Tan Hui , Sun Chaofeng , Li Guoliang 
Published: May 2018

The voltage-gated sodium channel 1.5 (Nav1.5), encoded by the SCN5A gene, is responsible for the rising phase of the action potential of cardiomyocytes. The sodium current mediated by Nav1.5 consists of peak and late components (INa-Pand INa-L). Mutant Nav1.5 causes alterations in the peak and late sodium current and is associated with an increasingly wide range of congenital arrhythmias. More than 400 mutations have been identified in the SCN5A gene. Although the mechanisms of SCN5A mutations leading to a variety of arrhythmias can be classified according to the alteration of INa-Pand INa-Las gain-of-function, loss-of-function and both, few researchers have summarized the mechanisms in this way before. In this review article, we aim to review the mechanisms underlying dysfunctional Nav1.5 due to SCN5A mutations and to provide some new insights into further approaches in the treatment of arrhythmias.Impact statementThe field of ion channelopathy caused by dysfunctional Nav1.5 due to SCN5A mutations is rapidly evolving as novel technologies of electrophysiology are introduced and our understanding of the mechanisms of various arrhythmias develops. In this review, we focus on the dysfunctional Nav1.5 related to arrhythmias and the underlying mechanisms. We update SCN5A mutations in a precise way since 2013 and presents novel classifications of SCN5A mutations responsible for the dysfunction of the peak (INa-P) and late (INa-L) sodium channels based on their phenotypes, including loss-, gain-, and coexistence of gain- and loss-of function mutations in INa-P, INa-L, respectively. We hope this review will provide a new comprehensive way to better understand the electrophysiological mechanisms underlying arrhythmias from cell to bedside, promoting the management of various arrhythmias in practice.
Thrombolysis for Venous Thromboembolism During Pregnancy: A Literature Review
Authors: Ho Vy T. , Dua Anahita , Lavingia Kedar , Rothenberg Kara , Rao Christina , Desai Sapan S. 
Published: May 2018

Background: Pregnancy is a hypercoagulable state, conferring an increased risk of venous thromboembolism (VTE). However, treatment algorithms for deep venous thrombosis and pulmonary embolism are based on studies of nonpregnant patients. Methods: A literature review of cases in which thrombolysis was used for the treatment of VTE during pregnancy was conducted using the PubMed (National Institutes of Health) database. Results: A PubMed database search of English language articles for reports of thrombolysis for the treatment of VTE in pregnancy identified 215 cases, including 183 cases of systemic thrombolysis, 19 cases of catheter-directed thrombolysis, and 13 cases of mechanical thrombectomy. For systemic thrombolysis, the maternal complication rate was 4.40% and the fetal complication rate was 1.65%. For catheter-directed thrombolysis, the maternal complication rate was 14.75% and the fetal complication rate was 5.2%. In cases of mechanical thrombectomy, there were no reported maternal or fetal complications. Conclusions: Although conservative strategies are preferred in pregnancy, thrombolysis is an adjunct for limb or life-threatening VTE. Review of past reports suggests low rates of maternal and fetal complications following systemic thrombolysis and mechanical thrombectomy but higher rates of complications after catheter-directed thrombolysis in the treatment of VTE during pregnancy.
The association of body mass index with endometriosis and disease severity in women with pain
Authors: Holdsworth-Carson Sarah J , Dior Uri P , Colgrave Eliza M , Healey Martin , Montgomery Grant W , Rogers Peter AW , Girling Jane E 
Published: May 2018

Introduction: There is a well-established inverse relationship between body mass index and frequency of endometriosis. However, these population-based studies have relied mostly on self-reported cases of endometriosis, rather than surgically confirmed endometriosis where disease severity has been objectively assessed. The aim of the current retrospective study was to establish whether the established relationship between endometriosis and low body mass index was independent of disease severity. Methods: Women with menstrual and/or pelvic pain undergoing laparoscopy for suspected endometriosis were recruited for this retrospective study (n = 509). Women were grouped by body mass index (kg/m2) according to World Health Organization criteria: underweight (<18.5), normal (18.5–24.99), pre-obese (25–29.99) or obese (≥30). Endometriosis was scored according to the revised American Fertility Society system. Data were analysed based on body mass index and endometriosis status to identify any relationship between body mass index and disease. Results: The average body mass index of women with endometriosis was 25.0 kg/m2. The body mass index distribution of women with endometriosis differed relative to women in the general population. As expected, fewer obese women had endometriosis than in the lower body mass index categories. However, the obese women who did have endometriosis had significantly higher revised American Fertility Society scores compared to women with normal and pre-obese body mass indices. Discussion: Our results are consistent with the established finding of an inverse relationship between body mass index and endometriosis. The novel finding from this study is that obesity is associated with increased disease severity and reduced frequency of stage I endometriosis. It remains unclear what role body mass index has in the cause or effect of endometriosis; we speculate that body mass index may be useful for sub-classifying the disease.
Mixed effects of remittances on child education
Authors: Bucheli José R. , Bohara Alok K. , Fontenla Matías 
Published: May 2018

Abstract
We exploit the size of the 2010 Ecuadorian Census to estimate the effect of remittances on secondary school enrollment across four key dimensions: gender, household wealth, rural vs. urban, and family migration status. Using a bivariate probit model that accounts for both endogeneity and non-linearity issues, we find both positive and negative effects of remittances on the likelihood of schooling. The strongest positive effects are for poorer, urban males, while the negative effects are for rural females. For children in wealthier households, the effects of remittances are either negative or non-significant. This suggests that the positive income effects of remittances may be offset by the negative effects of a missing parent due to migration, more visible in wealthier families where financial constraints may not be as binding. We find further support for this by estimating the effects of remittances conditional on migration status. Our results show positive effects on schooling for non-migrant households that receive remittances and no effects for children living in households where at least one parent has migrated. The sharp contrasts within and across groups, while using the same data and econometric specifications, help explain the lack of consensus in the literature.
OMPARATIVE STUDIES OF THE CONTENT OF PHENOLIC COMPOUNDS, FLAVONOIDS AND ANTIOXIDANT ACTIVITY OF APPLES OF DIFFERENT VARIETIES
Authors: Макарова (Makarova) Надежда (Nadezhda) Викторовна (Viktorovna) , Валиулина (Valiulina) Динара (Dinara) Фанисовна (Fanisovna) , Азаров (Azarov) Олег (Oleg) Игоревич (Igorevich) , Кузнецов (Kuznetsov) Анатолий (Anatolij) Александрович (Aleksandrovich) 
Published: May 2018

In this article discusses the most commonly used methods of investigation of antioxidants. Six varieties of apples (23-25-64, 23-17-22, 23-20-50, 23-25-51, 23-31-135, Sinap of Samara) were selected as objects of research, from the collection of the Research Institute "Zhigulevsky Gardens" "The harvest of 2016 grown on the territory of the Samara region. For the study was obtained hydroalcoholic extract (1 : 1) at 37 °C for 2 hours. The analysis for the maintenance of the total number of phenolic compounds content of gallic acid, flavonoids catechin content, antioxidant capacity with use of free radical DPPH (2,2-diphenyl-1-pikrilgidrazil), restoring forceb with method of FRAP (ferric reducing antioxidant power), the antioxidant activity in linoleic acid system. A significant number of methods to assess the antioxidant activity of the compounds according to the method systematically recording parameters used to determine antioxidant activity, including quantitative. As a result of a comparative study of the content of phenolic compounds, flavonoids, antiradical ability using the 2,2'-diphenyl-1-picrylhydrazyl reagent method, the FRAP restoring force with 2,4,6-tri(2-pyridyl)-1,3 reagent, 5-triazine, antioxidant activity on the linoleic acid model for six varieties of apples were identified as leaders by individual indicators (phenols - apples of variety 23-20-50, flavonoids - apples of variety 23-20-50, anti-radical ability – apples of variety 23-25-51, FRAP-values – apples of variety 23-20-50, antioxidant ability – Syn up of Samara), and in general for the majority of indicators - apples of variety 23-20-50.
COMPONENT COMPOSITION OF ESSENTIAL OIL OF MONARDA FISTULOSA L. GRASS FROM THE COLLEC-TION OF NIKITSKY BOTANICAL GARDEN
Authors: Никитина (Nikitina) Ангелина (Angelina) Сергеевна (Sergeevna) , Алиев (Aliyev) Аслан (Aslan) Мурадалиевич (Muradalievich) , Феськов (Feskov) Сергей (Sergej) Александрович (Aleksandrovich) , Никитина (Nikitina) Наталья (Natal'ja) Владимировна (Vladimirovna) 
Published: May 2018

The creation of promising varieties of medicinal plants with useful properties is an actual direction. The acquisition of new highly productive varieties of medicinal plants and their introduction into the culture are successfully implemented in the Nikitsky Botanical Garden, R. Krym. The purpose of this work was to determine the specific features of the essential oil composition of the highly productive varieties Monarda fistulosa L. to determine the prospects of its use in pharmacy and further standardization of raw materials. Essential oil from the aboveground part of Monarda fistulosa L. was obtained by hydrodistillation using the Ginsberg instrument, its content in the raw material reached 2.38% in terms of absolutely dry raw materials. The component composition of essential oil from the aboveground part of the Monarda fistulosa L. was studied by chromatography-mass spectrometry. The presence of 41 components was revealed, 38 of them were identified, the main group being monoterpenes and their derivatives. The highest content of p-cymene, thymol, thymoquinone, thymohydroquinone, carvacrol, γ-terpinene was found in the sample of essential oil. Evaluation of the data of chromatography-mass spectrometry confirms the prospects of using essential oil and Monarda fistulosa L. grass of the assayed variety in pharmaceutical and medical practice as an antimicrobial, anti-inflammatory, antifungal and immunostimulating agent.
GeoTAB: Clima, recursos hídricos e bacias hidrográficas na região de atuação da Embrapa Tabuleiros Costeiros
Authors: Cruz Marcus Aurélio Soares , Rocha Rafael Oliveira Franca , Silva Ana Alexandrina Gama da , Amorim Julio Roberto Araujo de , Aragão Ricardo de 
Published: May 2018

O Portal GeoTAB da Embrapa Tabuleiros Costeiros, por meio de suas bases ClimaTAB e HidroTAB, visa disponibilizar via web dados geoespaciais relacionados a clima, recursos hídricos e bacias hidrográficas em sua área de atuação, que é composta pelos Tabuleiros Costeiros e áreas adjacentes (TCNEB), fornecendo informações que podem ser de grande valia ao processo de gestão dos recursos hídricos. Neste estudo são apresentados alguns produtos resultantes de análises realizadas com dados dessas bases relacionados à variabilidade das precipitações médias anuais e mensais, características de relevo e bacias hidrográficas. As precipitações médias apresentam volumes com maior concentração entre março e julho e sobre a faixa litorânea leste dos TCNEB, variando de 1600 a 2100 mm por ano. Mais de 88% da área de estudo localiza-se em altimetria inferior a 100 m. Relevo Plano a Suavemente ondulado predomina em 54% da região. As bacias hidrográficas presentes na região apresentam média propensão a inundações, com coeficiente de forma médio da ordem de 1,77 e baixo coeficiente de variação.
Random deposition of particles with different angles
Authors: Vilas Boas Amanda Carvalho Augusto , Forgerini Fabricio Luchesi 
Published: May 2018

In this work we study numerically the effects of the angle of deposition of particles in the growth process of a thin-film generated by aggregation of particles added at random. The particles are aggregated in a random position of an initially flat surface and with a given angle distribution. This process gives rise to a rough interface after some time of deposition. We performed Monte Carlo simulations and, by changing the angle of deposition, we observed different results from the random deposition (RD) model. We measured the usual scaling exponents, namely, the roughness () and the growth () exponents. Our results show that the particles added non-perpendicularly to the substrate, can change the behavior in a discrete atomistic random deposition model. When particles are deposited with an angle of 45° in relation to the surface, the values of and are observed in the Random Deposition model. We also propose an analytic approach, using a differential stochastic equation to analyze the growth process evolution, and our theoretical results corroborate the computer simulations.
Sowing speed in no tillage system on early development of maize crop
Authors: Paulo Marcela Vieira , Tieppo Rafael Cesar , Modolo Alcir José , Dallacort Rivanildo , Santi Adalberto 
Published: May 2018

Sowing is a fundamental stage in crops’ cultivation process. If performed improperly, it can compromise the entire crop development. Seeding speed stands out as a key factor which can affect seeding quality. The objective of this study was to assess the effects of variation of working speed in maize initial establishment and in direct seeding’s’ quality parameters. The experiment was carried out in the municipality of Tangará da Serra – MT. Four seeding speeds were used V1 equal 1.11 (4.0), V2 equal 1.39 (5.0), V3 equal 1.67 (6.0) and V4 equal 1.94 m s-1 (7.0 km h-1). The assessed parameters were emergence speed index, emergence rate, seed deposition depth, plant spacing, and initial plant population. No interference of seeding speed variation was observed in seed deposition depth, emergence speed index and initial plant population. However, seeding speed influenced in plant spacing, in which speed increase was proportional to plant spacing increase.
Avaliação da resistência mecânica e absorção de água em cerâmica vermelha com incorporação de chamote
Authors: Zaccaron Alexandre , Galatto Sergio Luciano , Nandi Vitor de Souza , Fernandes Paulo 
Published: May 2018

O presente estudo visa analisar as propriedades tecnológicas de resistência mecânica e absorção de água em peças de cerâmica vermelha, com adição de diferentes percentuais de resíduos proveniente do processo pós-queima da fabricação de blocos de vedação (chamote). O estudo foi realizado em duas etapas, sendo a primeira a avaliação da massa padrão (STD) para produção de cerâmica vermelha e outras quatro formulações com diferentes percentuais (5, 10, 15 e 20 %) de adição do chamote como matéria-prima alternativa. Nessa primeira etapa, os corpos-de-prova foram confeccionados manualmente com auxílio de um molde de PVC. Para a segunda etapa, foram escolhidas a massa padrão (STD) e a formulação com 20 % para serem conformadas por extrusão e avaliar as propriedades tecnológicas em questão conforme a norma técnica ABNT NBR 15270. As peças foram queimadas – em ambas as etapas – a 900 °C, simulando os procedimentos padrão das indústrias cerâmicas. Foi possível observar na primeira etapa, que a resistência mecânica dos corpos-de-prova tende a diminuir com o aumento da absorção de água, como conseqüência da adição de maiores percentuais de chamote. Todavia, essa diferença se dá de forma pouco relevante. Já na segunda etapa, apesar da diferença ocasionada pela adição do resíduo, os corpos-de-prova atenderam as normas, ao serem ensaiados nas propriedades estudadas.
Controle estatístico de qualidade usando o método bootstrap
Authors: Da Silva Cleomacio Miguel , Vieira José Wilson , Neto Newton Adrião , Gonçalves Gabriela Lima 
Published: May 2018

O controle estatístico de qualidade é um procedimento de monitoração e manutenção que utiliza ferramentas estatísticas para avaliar a qualidade de produtos e serviços. Quando uma decisão precisa ser tomada para aceitar ou rejeitar produtos numa linha de produção, verifica-se o funcionamento do processo através da análise estatística do gráfico de controle. Somente assim, será possível verificar se um processo deve ser continuado ou deve ser ajustado para atingir a qualidade total. A ferramenta estatística conhecida como método bootstrap pode ser testada com a finalidade de verifcar sua operacionalidade no controle estatístico de qualidade. O método bootstrap tem sido bastante utilizado em diferentes áreas do conhecimento. Este método consiste de procedimentos computacionais intensivos usados para estudar estatísticas paramétrica e não paramétrica. Assim, o objetivo da presente pesquisa foi avaliar o uso do método bootstrap no controle estatístico de qualidade. Para isto, construiu-se um programa computacional em C++. Concluiu-se então, que o método bootstrap mostrou-se bastante eficiente na análise estatística de controle de qualidade, evitando a utilização de um modelo padrão de distribuição de probabilidade.