bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of venetoclax in relapsed chronic lymphocytic leukemia is influenced by disease and response variables
Authors: Roberts Andrew W. , Ma Shuo , Kipps Thomas J. , Coutre Steven E. , Davids Matthew S. , Eichhorst Barbara , Hallek Michael , Byrd John C. , Humphrey Kathryn , Zhou Lang , Chyla Brenda , Nielsen Jacqueline , Potluri Jalaja , Kim Su Young , Verdugo Maria , Stilgenbauer Stephan , Wierda William G. , Seymour John F. 
Published: April 2019

Abstract
To define the efficacy of venetoclax with extended follow-up and identify clinical or biological treatment effect modifiers, updated data for previously treated patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) enrolled in 4 early-phase trials were pooled. Rates of response, complete remission (CR/CRi), and undetectable minimal residual disease (U-MRD) were analyzed for all patients (n = 436) and for those patients who were planned to receive 400 mg/day monotherapy (n = 347). Univariate and multiple regression analyses were performed to identify the pretreatment factors associated with response rates and duration of response (DoR). Objective responses were documented in 75% of all patients, including 22% CR/CRi. Overall, 27% and 16% of the patients achieved U-MRD in blood and marrow, respectively. Estimated median progression-free survival (PFS), DoR, and time to progression were 30.2, 38.4, and 36.9 months, respectively. Similar efficacy outcomes were observed within the 400 mg/day monotherapy subset. For those who achieved CR/CRi, the 3-year PFS estimate was 83%. DoR was superior for patients achieving CR/CRi or U-MRD in landmark analyses. In multiple regression analyses, bulky lymphadenopathy (≥5 cm) and refractoriness to B-cell receptor inhibitor (BCRi) therapy were significantly associated with lower CR rate and shorter DoR. Fewer prior therapies were associated with higher CR rate, but not DoR. Chromosome 17p deletion and/or TP53 mutation and NOTCH1 mutation were consistently associated with shorter DoR, but not probability of response. Thus, both pretreatment factors and depth of response correlated with DoR with venetoclax. Patients without bulky lymphadenopathy, BCRi-refractory CLL, or an adverse mutation profile had the most durable benefit.
Broad-spectrum antibiotic use and poor outcomes in community-onset pneumonia: a cohort study
Authors: Webb Brandon J. , Sorensen Jeff , Jephson Al , Mecham Ian , Dean Nathan C. 
Published: April 2019

QuestionIs broad-spectrum antibiotic use associated with poor outcomes in community-onset pneumonia after adjusting for confounders?MethodsWe performed a retrospective, observational cohort study of 1995 adults with pneumonia admitted from four US hospital emergency departments. We used multivariable regressions to investigate the effect of broad-spectrum antibiotics on 30-day mortality, length of stay, cost andClostridioides difficileinfection (CDI). To address indication bias, we developed a propensity score using multilevel (individual provider) generalised linear mixed models to perform inverse-probability of treatment weighting (IPTW) to estimate the average treatment effect in the treated. We also manually reviewed a sample of mortality cases for antibiotic-associated adverse events.Results39.7% of patients received broad-spectrum antibiotics, but drug-resistant pathogens were recovered in only 3%. Broad-spectrum antibiotics were associated with increased mortality in both the unweighted multivariable model (OR 3.8, 95% CI 2.5–5.9; p<0.001) and IPTW analysis (OR 4.6, 95% CI 2.9–7.5; p<0.001). Broad-spectrum antibiotic use by either analysis was also associated with longer hospital stay, greater cost and increased CDI. Healthcare-associated pneumonia was not associated with mortality independent of broad-spectrum antibiotic use. In manual review we identified antibiotic-associated events in 17.5% of mortality cases.ConclusionBroad-spectrum antibiotics appear to be associated with increased mortality and other poor outcomes in community-onset pneumonia.
Hazards to avoid in future neonatal studies of nasal high-frequency oscillatory ventilation: lessons from an early terminated trial
Authors: Fischer Hendrik S. , Bührer Christoph , Czernik Christoph 
Published: April 2019

Abstract
Objective
To investigate whether nasal high-frequency oscillatory ventilation (nHFOV) started immediately after extubation of mechanically ventilated very low birth weight infants reduces the partial pressure of carbon dioxide at 72 h after extubation in comparison with nasal continuous positive airway pressure. This randomised controlled single-centre trial aimed to include 68 preterm infants at high risk of extubation failure.

Results
Implementation of the study protocol was feasible. However, from 2015 to 2017, only six patients could be recruited, leading to early termination of the trial. The slow recruitment was due to the introduction of new strategies to avoid endotracheal mechanical ventilation, which reduced the number of eligible infants. Moreover, the included infants failed their extubation more often than anticipated, thereby increasing the required sample size. Based on our single-centre experience, we provide information for study planning and discuss the specific requirements for future trial protocols on nHFOV. The extubation of high-risk infants into nHFOV could well be beneficial, but a multicentric approach is necessary to investigate this hypothesis.
Trial Registration Clinicaltrials.gov NCT02340299, on 16 January 2015
Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia
Authors: del-Pozo Jorge , MacIntyre Neil , Azar Ali , Headon Denis , Schneider Pascal , Cheeseman Michael 
Published: April 2019

ABSTRACT
Patients with mutations in the ectodysplasin receptor signalling pathway genes – the X-linked ligand ectodysplasin-A (EDA), the receptor EDAR or the receptor adapter EDARADD – have hypohidrotic ectodermal dysplasia (HED). In addition to having impaired development of teeth, hair, eccrine sweat glands, and salivary and mammary glands, HED patients have ear, nose and throat disease. The mouse strains Tabby (EdaTa) and downless (Edardl-J/dl-J) have rhinitis and otitis media due to loss of submucosal glands in the upper airway. We report that prenatal correction of EDAR signalling in EdaTa mice with the agonist anti-EDAR antibody rescues the auditory-tube submucosal glands and prevents otitis media, rhinitis and nasopharyngitis. The sparse- and wavy-haired (swh) rat strain carries a mutation in the Edaradd gene and has similar cutaneous HED phenotypes to mouse models. We report that auditory-tube submucosal glands are smaller in the homozygous mutant Edaraddswh/swh than those in unaffected heterozygous Edaraddswh/+ rats, and that this predisposes them to otitis media. Furthermore, the pathogenesis of otitis media in the rat HED model differs from that in mice, as otitis media is the primary pathology, and rhinitis is a later-onset phenotype. These findings in rodent HED models imply that hypomorphic as well as null mutations in EDAR signalling pathway genes may predispose to otitis media in humans. In addition, this work suggests that the recent successful prenatal treatment of X-linked HED (XLHED) in humans may also prevent ear, nose and throat disease, and provides diagnostic criteria that distinguish HED-associated otitis media from chronic otitis media with effusion, which is common in children.
Association between Lifelong Physical Activity and Disease Characteristics in HCM
Authors: AENGEVAEREN VINCENT L. , GOMMANS D. H. FRANK , DIEKER HENDRIK-JAN , TIMMERMANS JANNEKE , VERHEUGT FREEK W. A. , BAKKER JEANNETTE , HOPMAN MARIA T. E. , DE BOER MENKO-JAN , BROUWER MARC A. , THOMPSON PAUL D. , KOFFLARD MARCEL J. M. , CRAMER G. ETIENNE , EIJSVOGELS THIJS M. H. 
Published: April 2019

ABSTRACT

Purpose
Hypertrophic cardiomyopathy (HCM) is characterized by inappropriate left ventricular (LV) wall thickness. Adaptations to exercise can occasionally mimic certain HCM characteristics. However, it is unclear whether physical activity affects HCM genotype expression and disease characteristics. Consequently, we compared lifelong physical activity volumes between HCM gene carriers with and without HCM phenotype, and compared disease characteristics among tertiles of physical activity in phenotypic HCM patients.

Methods
We enrolled n = 22 genotype positive/phenotype negative (G+/P−) HCM gene carriers, n = 44 genotype positive/phenotype positive (G+/P+) HCM patients, and n = 36 genotype negative/phenotype positive (G−/P+) HCM patients. Lifelong physical activity was recorded using a questionnaire and quantified as metabolic equivalent of task hours per week.

Results
We included 102 participants (51 ± 16 yr, 49% male). Lifelong physical activity volumes were not different between G+/P+ and G+/P− subjects (16 [10–29] vs 14 [6–26] metabolic equivalent of task‐hours per week, P = 0.33). Among phenotypic HCM patients, there was no difference in LV wall thickness, mass, and late gadolinium enhancement across physical activity tertiles. Patients with the highest reported physical activity volumes were younger at the time of diagnosis (tertile 1: 52 ± 14 yr, tertile 2: 49 ± 15 yr, tertile 3: 41 ± 18 yr; P = 0.03), and more often had a history of nonsustained ventricular tachycardia (4% vs 30% vs 30%, P = 0.03).

Conclusions
Lifelong physical activity volumes are not associated with genotype-to-phenotype transition in HCM gene carriers. We also found no difference in LV wall thickness across physical activity tertiles. However, the most active HCM patients were younger at the time of diagnosis and had a higher arrhythmic burden. These observations warrant further exploration of the role of exercise in HCM disease development.
Rapid transcriptional responses to serum exposure are associated with sensitivity and resistance to antibody-mediated complement killing in invasive Salmonella Typhimurium ST313
Authors: Ondari Edna M. , Klemm Elizabeth J. , Msefula Chisomo L. , El Ghany Moataz Abd , Heath Jennifer N. , Pickard Derek J. , Barquist Lars , Dougan Gordon , Kingsley Robert A. , MacLennan Calman A. 
Published: April 2019

Background:SalmonellaTyphimurium ST313 exhibits signatures of adaptation to invasive human infection, including higher resistance to humoral immune responses than gastrointestinal isolates. Full resistance to antibody-mediated complement killing (serum resistance) among nontyphoidalSalmonellaeis uncommon, but selection of highly resistant strains could compromise vaccine-induced antibody immunity. Here, we address the hypothesis that serum resistance is due to a distinct genotype or transcriptome response inS. Typhimurium ST313.Methods: SixS. Typhimurium ST313 bloodstream isolates, three of which were antibody resistant, were studied. Genomic content (single nucleotide polymorphisms and larger chromosomal modifications) of the strains was determined by Illumina and PACBIO sequencing, and functionally characterized using RNA-seq, transposon directed insertion site sequencing (TraDIS), targeted gene deletion and transfer of selected point mutations in an attempt to identify features associated with serum resistance. Results: Sequence polymorphisms in genes from strains with atypical serum susceptibility when transferred from strains that were highly resistant or susceptible to a strain that exhibited intermediate susceptibility did not significantly alter serum killing phenotype. No large chromosomal modifications typified serum resistance or susceptibility. Genes required for resistance to serum identified by TraDIS and RNA-seq included those involved in exopolysaccharide synthesis, iron scavenging and metabolism. Most of the down-regulated genes were associated with membrane proteins. Resistant and susceptible strains had distinct transcriptional responses to serum, particularly related to genes responsible for polysaccharide biosynthesis. There was higher upregulation ofwcalocus genes, involved in the biosynthesis of colanic acid exopolysaccharide, in susceptible strains and increased expression offepE, a regulator of very long-chain lipopolysaccharide in resistant strains.Conclusion: Clinical isolates ofS. Typhimurium ST313 exhibit distinct antibody susceptibility phenotypes that may be associated with changes in gene expression on exposure to serum.
Study on Alloy Steel TEW 6582 Machined Surface Rougness Under Dry Machining
Authors: Napid Suhardi , Rafiq Yanhar Muhammad , Bakhori Ahmad , Hasibuan Abdurrozzaq , Krianto Sulaiman Oris , Asaad Mhd. 
Published: April 2019

The purpose of research is to study the surface roughness of machining results obtained to give consideration that the possibility of dry machining can be realized at alloy steel machining of TEW 6582. In the field of surface texture only discuss the machined surface roughness with some testing that is processing and data analysis can be done statistically. The TEW 6582 alloy steel samples were produced from dry machining operations with 9 cutting forms using standard L 9 (34). In this case 3 variations of tool wear are determined by tool edge wear (VB) = 0.1 mm, 0.3 mm and 0.6 mm including also in wet machining. To cut the work piece used CNC machine, optical microscope and surface test . The roughness test was obtained the roughness value with dry machining for optimum cutting conditions ie HPK1.0.1 = 1,467 μm, HPK8,0.3 = 2,133 μm and HPK8,0.6 = 2,8 μm whereas value in wet machining was found with HPB1,0.1 = 1,581 μm, HPB8.0.3 = 2,304 μm and HPB8,0.6 = 2,906 μm. From the above machining results data, HPK8.06 can be determined as the most optimum cutting condition which can be concluded that dry machining gives better machining results roughness through Ravg value and no significant difference is obtained when compared to wet machining after statistically analyzed, so that dry machining is a good chance that can be realized in manufacturing and automotive industries.
Survey on Fault Detection and Diagnosis Using Neural Network in WBAN
Authors: N.S.Kalpana R , P.Nallathai Dr 
Published: April 2019

Wireless Body Area Networks (WBAN) is the sensor network used for monitoring health information in e-health systems. WBAN is a combination of sensors used to obtain vital information from the body. It is a special type of WSN. WBAN technology should handle the data in a smart way by reacting to the monitored data and to evaluate the data. It requires fault detection and diagnosis methods for sensors used in WBAN. This paper gives a survey of different types of neural-network approaches for faults detection and diagnosis in WBAN using neural network.
Deisgn of Mobile Infant Incubator with Comforting Pillow
Authors: Janney.J Bethanney , KrishnaKumar S , Shree.P.B Anu , V Rayshma , Suresh Sanjana 
Published: April 2019

A mobile infant incubator is a preterm infant care medical tool which provides warmth, humidity and oxygen all in a controlled state of affairs as required by the New born baby. This incubator offers a clean condition, which has natural air, perfect and clean encompassing conditions for the infants. The main aim of the paper is to design and develop an Arudino based temperature and humidity control in an incubator.In the course of their initial weeks of lives infants are subjected to pain and soreness, so to conquer this major problem we have introduced a mechanism to traject maternal features to the infant. For this reasons the features are mimicked viva a pillow unit that has embedded with sensors and actuators. Our proposed system consists of sensors for monitoring critical parameters, Pillow unit for comforting the infants, GSM for transferring information to doctors and parents and Labview for output evaluation and all together controlled by Arudino microcontroller. Advances in electronic procedures combined with sparing costs influence humidity and temperature to govern realistic with fantastically precise and solid performance.
Acquiring and processing of female EEG signals of various wrist movements for neuro prosthetic applications
Authors: G. Umashankar , Juliet Vimala , Santhosh Sheeba 
Published: April 2019

Human brain contain neurons which generate electrical signals, this can be recorded through electro encephalograph(EEG). Sensory motor cortices are responsible for motor activity i.e., various body movements, among which wrist movement reveals frequency change in Alpha & Beta bands of EEG signal. The aim of this approach is to calculate frequency changes responsible for various wrist movements such as flexion, extension, clockwise rotation and anticlockwise rotation, pronation and supination of female in both eyes open and eyes close conditions using FFT, wavelet transform classifier, where the largest set of EEG data is reduced to dimensions and the spectral frequencies for particular wrist movements are classified and the statistical analysis is done of various trials for both eyes open and eyes close conditions in both time domain and frequency domain and the mean and standard deviation of various trials will be compared for eyes open and eyes close condition in both time domain and frequency domain and these values can be implemented for neuro prosthetic applications.
PLC based automatic grinding system for door frames
Authors: Rohith Mervin Noel , R Aravind , Joe S Bestley 
Published: April 2019

Usually in order to smoothen or flatten any surface we generally prefer grinding process, the grinding process can be done in surface area or metal portion in any possible areas or metal portion in any possible area we want. This research work is on automation, since automation can be done for grinding of door frames. This idea gained inertest is due to the increasing demand of door frames for the customers in huge amount of production rates. There are several methods to grind the door frames either it can be done by humans (man-made), because normally grinding is a process which is being done manually by humans and we also have several methods other than manual grinding techniques. By automation using â€œprogrammable logic controllersâ€Â (PLC) which can overcome the traditional relay logic controllers, the door frames can be preferably grinded in a fraction of seconds and production rates to gets higher. Since we use (PLC) being the industrial tool, it performs the step-by-step sequence combined by both mechanical and electrical parts. In this paper, theÂ proposed (PLC) based grinding automation is performed and finally compared with the conventional methods being used before grinding process and validated by using real time status obtained.Â Â
Traffic Management at Madhya Kailash Intersection along Rajiv Gandhi Road in Chennai
Authors: V Sampathkumar. , Simron Rajkumar Samuel 
Published: April 2019

This paper focuses on the improvement of the traffic flow at the three-major congested intersection located near Madhya Kailash, Tidel Park and SRP Tools along Rajiv Gandhi road in Chennai City. Road inventory survey and volume count survey have been conducted at the three intersections. Volume accumulation curves are developed to obtain the peak volume and peak time. From the analysis it is found that the peak volume is about 2321 passenger car equivalence (PCE), 2544 PCE and 2396 PCE at the three intersections respectively during peak hour. The volume to capacity ratio is about 1.29, 1.41 and 1.33 obtained which makes high level of congestion and poor level of service in turn shows an immediate need of traffic management measure. Transport system management concepts are suggested to manage the traffic flow which will improve the flow at the study intersections.Â Â
Nur Algorithm on Data Encryption and Decryption
Authors: Aminudin Nur , Maseleno Andino , K Shankar , Hemalatha S , Sathesh kumar K , . Fauzi , Irviani Rita , Muslihudin Muhamad 
Published: April 2019

Security is a priority in information system, especially in the exchange of data that are important or confidential. The information to be given to the party entitled to the information must be properly safeguarded, don’t fall into the other hands who have no right to such information. One way to maintain the security of information exchanged in a system can be done using cryptographic techniques. Cryptography is the art and science to hide information from third parties. In cryptography a person who has a private key can convert plaintext data into unique and unreadable data (ciphertext) and can convert existing ciphertext into plaintext form by using its private key. System development (System Development Lifecycle) can mean to construct a new system to replace old system, combined with prototyping technique to build a cryptographic system using Nur algorithm which is implemented using programming language used is assembly (MASM32). In Nur Aminuddin's Encryptor there are two data-reading techniques namely encryption technique (the technique of converting data from the original into unreadable code) and decryption technique (the techniques of reading unreadable codes become readable) Encryption technique is built by applying technique of modern cryptography which holds secrecy on the symmetric key, so the security of encryption depends only on the key and does not depend on whether the algorithm is known to people or not.
Study on Disaster Recovery in Cloud Environment
Authors: K.Ravindranath Dr , Raghupriya N , Krishna Vamsi P , Sharath Kumar D 
Published: April 2019

In Today's world information been produced in huge sum, which requires data recovery assistance. The cloud service providers give security to the client regardless of the possibility that systems are down, because of disaster. A lot of private information is produced which is put away in cloud. In this manner, the need for recovery of data services are developing in an order and needs an advancement of an well-organized powerful data rescue strategies, when information is lost in a disaster. The motivation behind recovery strategy to support client from gathering data from any alternate server whenever that server lost information and incapable to provide information to the client. On the way to accomplish the reason, numerous diverse procedures have been proposed. In circumstances like Flood, Fire, seismic tremors or any equipment glitch or any accidental deletion of information may never again remain accessible. The target of this recovery is to condense the intense data recovery procedures that are utilized as a part of cloud computing area. It additionally describes the cloud-based disaster recovery stages and recognize open issues identified with disaster recovery.