bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum Concentrations of Oocyte-Secreted Factors BMP15 and GDF9 During IVF and in Women With Reproductive Pathologies
Authors: Riepsamen Angelique H , Chan Karen , Lien Shelly , Sweeten Prudence , Donoghoe Mark W , Walker Glenda , Fraison Eloïse H J , Stocker William A , Walton Kelly L , Harrison Craig A , Ledger William L , Robertson David M , Gilchrist Robert B 
Published: June 2019

AbstractOocyte-secreted factors bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are critical for folliculogenesis and fertility. This study developed ELISAs for the measurement of BMP15 and GDF9 in serum and investigated their usefulness as biomarkers of female reproductive function. Serum samples were obtained from women undergoing infertility treatments (n = 154) and from perimenopausal and postmenopausal women (n = 28). Serum concentrations of BMP15 and GDF9 were analyzed in women relative to age, anti-Müllerian hormone, number of oocytes retrieved, and polycystic ovary syndrome (PCOS) after superovulation for in vitro fertilization. BMP15 and GDF9 immunoassays were validated for specificity, sensitivity (24 and 26 pg/mL, respectively), and reproducibility. BMP15 and GDF9 were detectable in 61% and 29% of women, respectively. BMP15 and GDF9 varied 64-fold and 15-fold, respectively, between women, but they did not change within subjects following ovarian stimulation with gonadotropins. Serum GDF9 concentration, but not BMP15 concentration, was associated with oocyte number retrieved in patients without PCOS (P = 0.018). GDF9 and BMP15 associations with oocyte number differed significantly (P < 0.05) with PCOS status. GDF9 concentrations were lower in poor responders (women with fewer than four oocytes retrieved or with cancelled cycles; P = 0.020). Serum BMP15, but not GDF9, was lower in women >55 years of age, compared with women of reproductive age (P < 0.01). This study develops and validates immunoassays to quantitate BMP15 and GDF9 in human serum and to correlate concentrations with female reproductive potential. Although assay sensitivities require improvement, this study demonstrates the diagnostic potential of oocyte-secreted BMP15 and GDF9 as serum biomarkers in reproductive medicine.
Angiogenic Abnormalities in Diabetes Mellitus: Mechanistic and Clinical Aspects
Authors: Fadini Gian Paolo , Albiero Mattia , Bonora Benedetta Maria , Avogaro Angelo 
Published: June 2019

Abstract

Context
Diabetes causes severe pathological changes to the microvasculature in many organs and tissues and is at the same time associated with an increased risk of coronary and peripheral macrovascular events. We herein review alterations in angiogenesis observed in human and experimental diabetes and how they contribute to diabetes onset and development of vascular complications.

Evidence Acquisition
The English language medical literature was searched for articles reporting on angiogenesis/vasculogenesis abnormalities in diabetes and their clinical manifestations, mechanistic aspects, and possible therapeutic implications.

Evidence Synthesis
Angiogenesis is a complex process, driven by a multiplicity of molecular mechanisms and involved in several physiological and pathological conditions. Incompetent angiogenesis is pervasive in diabetic vascular complications, with both excessive and defective angiogenesis observed in various tissues. A striking different angiogenic response typically occurs in the retina vs the myocardium and peripheral circulation, but some commonalities in abnormal angiogenesis can explain the well-known association between microangiopathy and macroangiopathy. Impaired angiogenesis can also affect endocrine islet and adipose tissue function, providing a link to diabetes onset. Exposure to high glucose itself directly affects angiogenic/vasculogenic processes, and the mechanisms include defective responses to hypoxia and proangiogenic factors, impaired nitric oxide bioavailability, shortage of proangiogenic cells, and loss of pericytes.

Conclusions
Dissecting the molecular drivers of tissue-specific alterations of angiogenesis/vasculogenesis is an important challenge to devise new therapeutic approaches. Angiogenesis-modulating therapies should be carefully evaluated in view of their potential off-target effects. At present, glycemic control remains the most reasonable therapeutic strategy to normalize angiogenesis in diabetes.
Molecular form and function of the cytokinetic ring
Authors: Mangione M. C. , Gould Kathleen L. 
Published: June 2019

ABSTRACT
Animal cells, amoebas and yeast divide using a force-generating, actin- and myosin-based contractile ring or ‘cytokinetic ring’ (CR). Despite intensive research, questions remain about the spatial organization of CR components, the mechanism by which the CR generates force, and how other cellular processes are coordinated with the CR for successful membrane ingression and ultimate cell separation. This Review highlights new findings about the spatial relationship of the CR to the plasma membrane and the arrangement of molecules within the CR from studies using advanced microscopy techniques, as well as mechanistic information obtained from in vitro approaches. We also consider advances in understanding coordinated cellular processes that impact the architecture and function of the CR.
Pengaruh konsentrasi zpt giberalin dan lama penyinaran terhadap pertumbuhan dan hasil tanaman krisan (Chrysanthemum morifolium)
Authors: Rifalasna Dian , Sumarsono Sumarsono , Kristanto Budi Adi 
Published: June 2019

ABSTRACT This study aims to examine the effect of giberalin ZPT concentration and duration of irradiation on the growth and yield of chrysanthemum (Chrysanthemum morifolium) cut flowers. The study took place in February - June 2018. The study was conducted in Mendongan Village, Sumowono District, Semarang Regency, Central Java. ABSTRACT This study aimed to examine the effect of giberalin concentration and duration of irradiation on the growth and yield of chrysanthemum (Chrysanthemum morifolium) cut flowers. The study took place in February - June 2018. The study was conducted in Mendongan Village, Sumowono District, Semarang Regency, Central Java. The design used in the study was a Completely Randomized Factorial 4x4 Design. The first factor was gibberallin treatment consisted of G1: GA 0 ppm, G2: GA 10 ppm, G3: GA 20 ppm, G4: GA 30 ppm. The second factor was the irradiation time consisted of R1: 1 hour irradiation time, R2: 2 hours irradiation time, R3: 3 hours irradiation time, and R4: 4 hours irradiation time. Parameters observed were plant height, stem diameter, number of leaves, leaf area, number of flowers, flower diameter, flowering age and flower harvesting age.The results showed that the treatment of giberalin concentration significantly affected the parameters of the amount of interest. While the irradiation treatment time significantly affected the parameters of plant height, number of leaves, flower diameter, stem diameter, age of flowering, and leaf area. Keywords: Giberalin, Chrysanthemum, Irradiation Period ABSTRAK Penelitian ini bertujuan untuk mengkaji pengaruh konsentrasi ZPT giberalin dan lama penyinaran terhadap pertumbuhan dan hasil bunga potong tanaman krisan (Chrysanthemum morifolium). Penelitian berlangsung pada bulan Februari - Juni 2018. Penelitian dilakukan di Desa Mendongan, Kecamatan Sumowono, Kabupaten Semarang, Jawa Tengah. Rancangan yang digunakan dalam penelitian adalah Percobaan Faktorial 4x4 Rancangan Acak Lengkap (RAL). Faktor pertama yaitu perlakuan giberalin sebanyak 4 taraf yaitu G1 : GA 0 ppm, G2 : GA 10 ppm, G3 : GA 20 ppm, G4 : GA 30 ppm. Faktor kedua adalah lama penyinaran dengan 4 taraf yaitu R1 : lama penyinaran 1 jam, R2 : lama penyinaran 2 jam, R3 : lama penyinaran 3 jam, dan R4 : lama penyinaran 4 jam. Parameter yang diamati adalah tinggi tanaman, diameter batang, jumlah daun, luas daun, jumlah bunga, diameter bunga, umur berbunga dan umur panen bunga. Hasil penelitian menunjukkan bahwa konsentrasi giberalin berpengaruh nyata terhadap peningkatan jumlah bunga yang bertambah banyak. Sedangkan lama penyinaran berpengaruh nyata terhadap peningkatan tinggi tanaman, jumlah daun, diameter bunga, diameter batang, umur berbunga, dan luas daun. Kata Kunci :Giberalin, Krisan, Lama Penyinaran
Respon pertumbuhan dan produksi tanaman kedelai (Glycine max L.) pada berbagai dosis dan jenis pupuk organik
Authors: Zahrotun Nur , Yafizham Yafizham , Fuskhah Eny 
Published: June 2019

ABSTRAK Penelitian bertujuan untuk mengkaji pengaruh interaksi antara dosis dan berbagai jenis pupuk organik terhadap pertumbuhan dan produksi tanaman kedelai. Penelitian telah dilaksanakan pada bulan Mei – Agustus 2017 di Lahan Percobaan dan Laboratorium Ekologi dan Produksi Tanaman, Fakultas Peternakan dan Pertanian, Universitas Diponegoro, Semarang. Penelitianmenggunakan Rancangan Acak Lengkap (RAL) Faktorial 2 x 5 dengan 3 ulangan. Faktor pertama adalah dosis pupuk yaitu D1 : 50 kg P/ha dan D2 : 100 kg P/ha. Faktor kedua adalah jenis pupuk yaitu J0 : SP-36, J1 : bioslurry, J2 : kotoran sapi, J3 : kotoran kambing dan J4 : kotoran ayam. Parameter yang diamati adalah tinggi tanaman, jumlah daun, jumlah polong total dan bobot 100 biji. Data dianalisis menggunakan analisis ragam dan apabila terdapat pengaruh nyata dilanjutkan dengan Uji Duncan Multiple Range Test (DMRT) taraf 5%. Hasil penelitian menunjukkan bahwa jenis pupuk kotoran kambing mampu meningkatkan pertumbuhan dan produksi tanaman kedelai paling tinggi dibandingkan dengan pupuk kotoran ayam, kotoran sapi, bioslurry dan SP-36 dengan dosis pupuk 50 kg P/ha. Kata kunci : kedelai, pupuk organik, pupuk SP-36.ABSTRACT The research aimed was to study the interaction between dosages and kinds of organic fertilizer on growth and yield of soybean. The research was conducted in May - August 2017 at Experimental Field and Ecology and Plant Production Laboratory, Faculty of Animal and Agriculture, Diponegoro University, Semarang. The research design used completely randomized design with factorial design 2 x 5 with 3 replications. The first factor were organic fertilizer dosages D1 : 50 kg P/ha and D2 : 100 kg P/ha. The second factors were kind of organic fertilizers J0 : SP-36, J1 : bioslurry, J2 : cow manure, J3 : goat manure, and J4 : chicken manure. The parameters observed were plant height, number of leaves, total number of pod, and 100 seeds weight. Data analyzed using analysis of variance and using Duncan Multiple Ranged Test on alpha 5%. The result showed that the goat manure fertilizer can increase the growth and production of soybean plant is highest compared with chicken manure, cow manure, bioslurry and SP-36 with dosage of 50 kg P/ha. Keywords : soybean, organic fertilizer, fertilizer SP-36.
Exploring identities of novice mainland Chinese teachers in Hong Kong: Insights from teaching creative writing at primary schools across borders
Authors: Teng (Mark) Feng , YIP Jesse W. C. 
Published: June 2019

AbstractThis study, drawing upon data triangulated from interviews, classroom research reports, and school documents, sheds light on how cross-border teachers from mainland China to Hong Kong construct and negotiate their identities when teaching English creative writing. Using identity control theory (ICT) this study examines discursive and complex identity development and reveals contextual and interpersonal factors that hinder identity construction among teachers of English creative writing. Factors include isolation from local colleagues, failure to integrate into the host community due to cultural and linguistic differences, standardized school instruction, heavy workloads, students’ distrust, and students’ low English proficiency. Cross-border teachers were found to experience negative emotions including stress, anger, and unease due to failed teacher identity verification in a new land. This study contributes to theoretical knowledge of ICT, suggesting inaction and secondary emotions as outcomes of the incongruence between the meanings of identity standard and input. Relevant theoretical and pedagogical implications are also discussed.
Lessons learned about humor from J.C.H. Davies and examples in his home collection
Authors: Abe Goh 
Published: June 2019

AbstractThis essay starts with a story about Christie’s collections at his home from around the world that he collected during his field research. The postcard from Australia on an Aussie Gentlemen fits into his description of Australians in the jokes as “coarse Australians”. Christie explained the Essexgirl jokes in London and I learned the importance of contexts hidden behind the jokes such as socio-cultural characteristics, mobility and social division in UK. Christie’s analysis of the Japanese jokes about stupidity revealed the prototype of ethnic jokes in Japan.From the episode at his home in Reading I will reflect on his father’s influence on his humor research.
The Chinese as targets in Polish humorous discourse
Authors: Brzozowska Dorota , Chłopicki Władysław 
Published: June 2019

Abstract
The paper discusses contemporary Polish humor which features references to Chinese language and culture. Together with the ideological, political, financial and economic visibility of China, its presence in Polish humorous discourse is on the rise. Jokes, cabaret sketches and visual materials, such as memes, more and more frequently use the Chinese as targets for entertaining the audience. The article will analyze the instances of Polish humorous discourse (largely Internet memes) to show which are the most frequent specific stereotypes about the Chinese and how that relates to Davies’s models of target choice. The results suggest that Polish humor about the Chinese as an untypical case of center-periphery relations constitutes an extension of Davies’s model in that Poles see the Chinese as both comically “stupid” and “clever”. The specific comic scripts evoked by the humorous material include not only that of cheap Chinese products, incomprehensible language or proverbs and unrecognizability of the Chinese people from other Asians (all considered scripts of a periphery), but also of the huge population and high sophistication of Chinese civilization (perceived as a center). Some of our humor material, however, is better explained using Davies’s monopoly-competition model due to references to authoritarian leaders.
Severe, persistent neonatal hypoglycemia as a presenting feature in patients with congenital hypopituitarism: a review of our case series
Authors: Mehta Shilpa , Brar Preneet Cheema 
Published: June 2019

Abstract

Background
Persistent hypoglycemia (PH) beyond 3 days of life warrants investigation which includes a critical sample. We report our case series of five neonates who presented with PH as the first sign of congenital hypopituitarism.

Design
This is a case series.

Methods/Results
This is a case series of five neonates evaluated at our academic institution in a 3-year period (2013–2016), who presented with persistent severe hypoglycemia and were subsequently diagnosed with congenital hypopituitarism. All neonates were full term (mean gestational age 39.8 ± 1.4 weeks) born by caesarian section with a mean weight of 3.5 ± 0.16 kg and a mean length of 51.2 ± 1.2 cm at birth. All five neonates had PH beyond 3 days with an average blood glucose (BG) <35 mg/dL at presentation, requiring a mean glucose infusion rate (GIR) of 7.22 ± 1.98 mg/kg/min. The average BG during the critical sample was 42 ± 0.16 mg/dL (three patients). The mean duration of requirement of the glucose infusion was 6.2 ± 3 days during the immediate neonatal period. Diagnosis of the hypopituitarism took 2–52 days from the initial presentation of hypoglycemia. Besides growth hormone (GH) deficiency, cortisol deficiency was diagnosed in all the five neonates. Neuroimaging findings in all the neonates were consistent with pituitary stalk interruption syndrome (hypoplastic anterior pituitary, ectopic posterior pituitary [EPP] and interrupted pituitary stalk).

Conclusions
Hypoglycemia is a common metabolic complication affecting an infant in the immediate neonatal period. Delay in the diagnosis of hypopituitarism presenting as hypoglycemia is the result of the lack of awareness among neonatologists and/or pediatricians. We propose that providers be cognizant that PH can be the only presentation of hypopituitarism in the neonatal period. Therefore, having a high index of suspicion about this condition can avoid a delay in the evaluation, diagnosis and treatment of hypopituitarism.
Chemical effects of nuclear transformations and possible formation of unknown derivatives with N-phenylquinazolinium structure
Authors: Shchepina Nadezhda E. , Avrorin Viktor V. , Badun Gennadii A. , Shurov Sergey N. , Shchepin Roman V. 
Published: June 2019

Abstract
Quinazoline derivatives are well known to have a diverse array of therapeutic activities. Unfortunately, “classic” chemical synthesis does not provide an opportunity for the formation of N-phenyl quaternary 1,3-diazinium compounds. A devised nuclear-chemical method of synthesis based on chemical effects of nuclear transformations enables a new way of the direct nitrogen atom phenylation by the nucleogenic (generated by tritium β-decay) phenyl cations in 1,3-diazines, furnishing, based on our prediction, formation of previously unknown derivatives with N-phenyl quaternary quinazolinium scaffold.
Effect of maleic anhydride content on physico-mechanical properties of γ-irradiated waste polypropylene/corn husk fibers bio-composites
Authors: EL-Zayat Mai M. , Mohamed Maysa A. , Shaltout Nawal A. 
Published: June 2019

Abstract
Biocomposites of waste polypropylene (wPP) with 20 phr (part per 100 parts of [wPP]) corn husk fibers (CHF) as bio-filler were prepared for environmental aspect. Maleic anhydride (MAH) was used, with 5, 10 phr concentration as compatabilizer was carried out. The obtained biocomposites were irradiated by γ radiation ranging from 5 to 25 kGy. Mechanical, physical and thermal properties of the biocomposites were studied to evaluate the effect of CHF addition on the properties of obtained composites. It has been found that there is deterioration in all properties. However, by the addition of MAH, the former properties were improved. The obtained results were confirmed by Fourier transform infrared (FTIR) and scanning electron microscopy (SEM).
Una aproximación general al transhumanismo y su problematización
Authors: Terrones Rodríguez Antonio Luis 
Published: June 2019

El movimiento transhumanista está despertando un gran interés en las últimas décadas con sus polémicos postulados y cuando sus propuestas son conocidas nadie queda indiferente ante las mismas. Diversos pensadores como Jürgen Habermas, Michael Sandel, Peter Sloterdjick o Nick Bostrom han escenificado una enriquecedora discusión en torno a los postulados transhumanistas. El transhumanismo defiende una mejora de la condición humana por medio de las tecnologías más avanzadas, entre las que se encuentran la biotecnología, la nanotecnología, la inteligencia artificial, etc. Son diversas las opciones para emprender el camino transhumanista: mejora de los hijos, mejora física, cognitiva y emocional, y lucha contra el envejecimiento. Además, las tecnologías de mejoramiento de la especie generan problemáticas de tipo social y político al insertarse en contextos con identidades sociales fuertemente marcadas, desigualdad económica y discriminación ética y racial. Así pues, es fundamental invitar a una reflexión ética sobre los postulados transhumanistas.
HUBUNGAN ANTARA KEMAMPUAN GURU DALAM MELAKUKAN PENGELOLAAN LINGKUNGAN BELAJAR DENGAN MOTIVASI BELAJAR ANAK USIA DINI
Authors: Ramdhayani Azmi Noor , Agustin Mubiar , Mariyata Rita 
Published: June 2019

Abstrak : The Relationship Between the Ability of Teachers in Managing the Learning Environment to Early Childhood Learning Motivation. This study aims to determine the relationship between the ability of teachers in managing the learning environment to early childhood learning motivation. This research using correlational. The study subjects were 13 teachers. Data collection techniques in this research thorough a questionnaire containing the ability of techers in managing the laerning environment and a questionnaire about the child’s learning motivation. The data analisys technique used quantitative desciptive data analysis with several stages including the validation peocess, realibilitas, correlation analysis and conclusion. The results showed a 100% ability of techers in managing the learning environment in both categories. Both the magnitude of correlation 0,584 so it can be concluded there is a positive relationship between the ability of teachers in managing the learning environment to the children’s learning motivation. Recommendations given to teachers, teachers are expected to further enhance their ability to manage the learning environment because it is not directly the ability of techers in managing the learning environment influence the creation of early childhood’s learning motivation.Abstrak: Hubungan Antara Kemampuan Guru dalam Melakukan Pengelolaan Lingkungan Belajar dengan Motivasi Belajar Anak Usia Dini. Penelitian ini bertujuan untuk mengetahui hubungan antara kemampuan guru dalam melakukan pengelolaan lingkungan belajar dengan motivasi belajar anak usia dini. penelitian ini menggunakan metode korelasional. Subjek penelitian berjumlah 13 orang guru. Teknik pengumpulan data dalam penelitian ini, yaitu melalui angket yang berisi kemampuan guru dalam melakukan pengelolaan lingkungan belajar dan angket mengenai motivasi belajar anak. teknik analisis data yang digunakan adalah analisis data deskriptif kuantitatif dengan beberapa tahapan diantaranya adalah proses validasi, reliabilitas, analisis korelasi, dan penarikan kesimpulan. Hasil penelitian menunjukkan 100% kemampuan guru dalam melakukan pengelolaan lingkungan belajar dalam kategori baik, dan 100% motivasi belajar anak usia dini dalam kategori baik. Besarnya korelasi keduanya yaitu sebesar 0,854 sehingga dapat disimpulkan terdapat hubungan yang positif antara kemampuan guru dalam melakukan pengelolaan lingkungan belajar dengan motivasi belajar anak. Rekomendasi yang diberikan untuk guru yaitu guru diharapkan lebih meningkatkan lagi kemampuan guru dalam melakukan pengelolaan lingkungan belajar karena secara tidak langsung kemampuan guru dalam melakukan pengelolaan lingkungan belajar ikut mempengaruhi terciptanya motivasi belajar anak.