bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Depressive Symptoms on the Quality of Life of Patients with Type 2 Diabetes in Jazan Region, KSA
Authors: Albasheer Osama B. 
Published: October 2018

Background:
The purpose of this study is to determine the impact of depressive symptoms
on the quality of life of type 2 diabetic patients (T2DM).

Methods:
A cross-sectional study of 332 T2DM patients aged ≥18 years living in Jazan region of Saudi
Arabia was conducted. Validated questionnaire was used for demographic and disease characteristics.
Depressive symptoms of the participants were assessed using the Patient Health Questionnaire (PHQ-9).
The Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q-SF) was utilized
to assess the degree of life enjoyment and satisfaction.

Results:
Depressive symptoms were observed in 34.7% (112) of the total participants. The overall sense
of wellbeing (mean 3.23, P. value 0.000), physical (mean 3.37, P. value 0.003), psychosocial (mean
2.99 P. value 0.000) and social domains (mean 3.53, P. value 0.000) of quality of life were significantly
reduced in T2DM patients with depressive symptoms.

Conclusion:
The impact of depressive symptoms on quality of life of T2DM patients was more significant
than the impact of diabetes alone. Symptoms of depression reduce the individual coping and hence
reduce functioning. This study emphasizes the vital importance of an integrated holistic approach that
addresses both the practical and emotional issues in diabetes care.
Myxedema Heart Disease: A Rare Disease Entity: Case Report and Brief Review of the Literature
Authors: Chaudhry Muhammad Ali , Grazette Luanda , Fong Michael W. 
Published: October 2018

Background:
Myxedema heart disease is an extremely rare disease entity and should be
suspected in patients with unexplained heart failure refractory to conventional treatment.
Myxedema coma with co- existent heart disease is not well known and very few cases have been
reported.

Conclusion:
Here, we present an interesting case of myxedema coma with severe valvular cardiomyopathy
followed by a concise review of the literature with special emphasis on epidemiology,
pathophysiology, diagnosis and therapeutic modalities.
In vitro Antifungal Activity of Dihydropyrimidinones/Thiones Against Candida albicans and Cryptococcus neoformans
Authors: de Azambuja Gabriel O. , Svetaz Laura , Gonçalves Itamar L. , Corbelini Patricia F. , von Poser Gilsane L. , Kawano Daniel F. , Zacchino Susana , Eifler-Lima Vera L. 
Published: October 2018

Background:
Since the Monastrol discovery in 1999 as the first inhibitor of Eg5, functionalized
dihydropyrimidinones/thiones (DHPMs) have emerged as prototypes for drug design in different
targets. The present work aimed to evaluate the antifungal activity of a chemical library of DHPMs.

Methods:
The compounds were obtained employing Biginelli reaction. Their antifungal activities were
assessed against C. neoformans and C. albicans.

Results:
The compounds 1-i and 1-k inhibited moderately the fungal growth of C. neoformans, with
compound 2-k presenting MIC80 values of 62.5-125 µg·mL-1. Considering activity against C. albicans,
the compounds 1-i and 1-n present an MIC50 value of 125-250 µg·mL-1.

Conclusion:
The changes performed in DHPM scaffold appear to be valuable for generating compounds
with potential antifungal effect.
Improved Solubility of Itraconazole Binary Dispersions using Neem Gum: Development and Characterization of Topical Gel
Authors: Nagpal Manju , Raj Nisha , Thakur Gurjeet Singh , Aggarwal Geeta 
Published: October 2018

Background:
Itraconazole is a triazole derivative and possesses structural similarities to the
azole group (imidazoles and triazoles). It is a broad spectrum fungistatic. It belongs to BCS class II
category i.e. it has poor solubility and high permeability.

Objective:
Dissolution enhancement of poorly soluble itraconazole using purified neem gum as a natural
carrier via binary dispersions and other methods was studied. Topical gel formulations of binary dispersions
were developed and evaluated for in vitro and in vivo antifungal activity.

Methods:
Five batches of solid dispersions (SD1-SD5) in various ratios of drug: neem gum were prepared
by the solvent evaporation technique. Other mixtures were also prepared by kneading, cogrinding,
physical mixing methods and evaluated further. Topical gel formulations were further developed
and evaluated for antifungal activity (both in vitro and in vivo).

Results:
Equilibrium solubility studies of various mixtures indicated SD3 (1:3) as the optimum batch
out of all solid dispersion batches. Equilibrium solubility studies of mixtures (KM, CGM, PM, SM)
indicated significant solubility enhancement of kneading mixture in comparison to other mixtures. FTIR
studies indicated no interaction of the drug to the polymer. DSC, SEM and XRD studies indicated a
transition from crystalline to the amorphous state of the drug. SD3 batch showed remarkably improved
dissolution characteristics (100% drug release in 1.5 h) in comparison to the pure drug (38% in 2h).
Further, the topical gel of SD3 was evaluated for in vitro diffusion, in vitro and in vivo antifungal activity.
Sustained drug release (53% in 24 h) was observed in SD3 based gel formulation which is significantly
higher than that in comparison to pure drug based gel (30% in 24 h). The increased area of zone
of inhibition of SD3 based gel indicated better antifungal activity of the SD3 gel formulation. Further
histopathology examination of skin specimens indicated enhanced efficacy of SD3 based gel in comparison
to pure drug based gel.

Conclusion:
Solid dispersion based topical gel formulation exhibits better antifungal activity in comparison
to pure drug based gel.
Characterization, Bioactive Compounds and Antioxidant Potential of Açaí (Euterpe oleracea) Genotypes
Authors: do C.M.R. Torma Priscila , de L. Monteiro Patric , Carvalho Ana V. , Flôres Simone H. , Augusti Paula R. , de O. Rios Alessandro 
Published: October 2018

Background:
Açaí (Euterpe oleracea), a “superfruit” consumed worldwide, is a Brazilian
Amazon native fruit, with high nutritive value due to its high content of lipids, proteins, and fibers, besides
bioactive compounds, such as anthocyanins, carotenoids and phenolic compounds in its composition
associated with biological action beneficial to health. The increased consumption of this fruit has
stimulated breeding programs in the search of plants and fruits with higher productivity and bioactive
compounds, generating information for the development of new cultivars with improved attributes. This
work aimed to study six different genotypes of açaí, developed by the breeding program, evaluating
their physicochemical characteristics and proximate composition, bioactive compounds and antioxidant
activity.

Methods:
The genotypes were analyzed for titratable acidity, pH, total soluble solids and proximate
composition, such as moisture, protein, lipids, total fiber, carbohydrates and ashes contents. A spectrophotometric
method using Folin-Ciocalteau reagent performed the phenolic compounds analysis and
HPLC evaluated carotenoids and anthocyanins extracted exhaustively. The ABTS assay evaluated the
antioxidant activity.

Results:
The L06P13 and L09P09 genotype presented higher content of total fiber, carbohydrates, and
ashes when compared to the commercial sample used as a standard. Furthermore, L22P13 genotype
showed the highest content of total anthocyanins (6745.81 mg/100g), total carotenoids (118 μg/g) and
antioxidant activity (674.83 μM Trolox/g) when compared to commercial sample.

Conclusion:
The results revealed promising açaí genotypes and support the importance of advances in
the area of functional foods and breeding programs.
Hypoglycemia among Insulin-treated Patients with Diabetes: Egypt Cohort of IO HAT Study
Authors: El Hefnawy Mohamed Hesham Mohamed Fahmy , Abdelaaty Talaat Abd el Fattah , Bassyouni Atef Abdelmoniem , Saleem Hesham Magdeldin , Khalid Mohsen Mostafa Mussa , Toaima Dalia Nabil , Maree Mohamed Ahmed Gaber 
Published: October 2018

Objectives:
The study aims to assess the real-world incidence of hypoglycemia in patients with Type 1 Diabetes Mellitus (T1DM) or Type 2 Diabetes Mellitus (T2DM) in Egypt cohort of the International Operations Hypoglycemia Assessment Tool (IO HAT) study.

Methods:

This is a non-interventional study to estimate hypoglycemia in eligible patients with T1DM or T2DM, aged ≥18 years and treated with insulin for >12 months, who have completed self-assessment questionnaires to record demography, treatment information, and hypoglycemia during the 6-month/4-week retrospective and 4-week prospective periods. Data on hypoglycemia for this sub-analysis were collected from DM patients of Egyptian cohort who were recruited in IO HAT study across 36 sites in Egypt between 22 Nov 2014 and 15 Apr 2015.

Results:
Percentage of patients who reported at least one hypoglycemic event in the prospective period was any: T1DM: 96.3% (95% confidence interval [CI]: 89.6%, 99.2%) and T2DM: 93.1% (95% CI: 89.8%, 95.6%) and severe: T1DM: 67.5% (95% CI: 56.1%, 77.6%) and T2DM: 64.2% (95% CI: 58.7%, 69.4%). An estimated rate of any and severe hypoglycemia in the prospective period was 63.3 (95% CI: 57.2, 69.9) events per patient year (PPY) and 28.9 (95% CI: 24.8, 33.4) events PPY, respectively, for patients with T1DM and 32.0 (95% CI: 29.8, 34.3) events PPY and 15.5 (95% CI: 14.0, 17.1) events PPY, respectively, for patients with T2DM. Hypoglycemic rate was independent of glycated hemoglobin levels.

Conclusion:
The self-reported hypoglycemia data from Egypt confirms that hypoglycemia is under-reported. The high impact of hypoglycemia on the Egyptian DM patients and healthcare system warrants patient education to prevent hypoglycemia.
Novel Diazenyl Containing Phenyl Styryl Ketone Derivatives As Antimicrobial Agents
Authors: Sivasankerreddy L. , Nagamani B. , Rajkumar T. , Babu M.S. , Subbaiah N.Y. , Harika M.S. , Nageswarao R. 
Published: October 2018

Background:
Antibiotics play an important role in the treatment of infections to the humans
and at the same time, irrational, frequent prescription of higher antibiotics, change in gene
composition of microorganisms are all the reasons behind the development and introduction of new
antibiotics against different microorganisms.

Objective:
In this project, an attempt has been made to synthesize some derivatives of diazenyl
containing phenyl styryl ketones and also their in vitro screening was conducted against Mycobacterium
tuberculosis, Escherichia coli, Klebsiella pneumonia, Bacillus subtilis, Staphylococcus aureus,
Aspergillus niger and Candida albicans.

Methods:
Ten molecules were synthesized which are diazenyl containing chalcones. 4-
aminoacetophenone was diazotised and piperidine was coupled with the formed diazonium chloride.
Further, the acetoxy group underwent Claisen-Schmidt condensation with differently substituted
aldehydes to form the final compounds- the chalcones. The proposed chemical structures
were confirmed by different spectroscopic techniques like FTIR, 1H NMR and Mass spectroscopy.
TLC was used to know that the reactants were exhausted and the formation of the product occurred.
Sharp melting point of the compounds concludes the purity.

Results:
The MIC of the compounds 3CP, 3DP, 3EP and 3GP is 20 times the MIC of the standard
fluconazole drug against Aspergillus niger. The compound 3GP is as equipotent as the standard
drug Pyrazinamide with MIC of 3.12 µg/ml against Mycobacterium tuberculosis.

Conclusion:
The results are quite promising which on further studies may lead to drug molecules
against different microorganisms. Especially, 3EP can be considered as a broad spectrum agent due
to its potent activity against different microorganisms like Staphylococcus aureus, Escherichia
coli, Klebsiella pneumonia and Candida albicans.
ATC/DDD Directed Classification of Neural Ayurvedic Medicines
Authors: Arora Malika , Kaur Manpreet , Bansal Parveen , Arora Manish 
Published: October 2018

Introduction:People have been using herbs for health care since Vedic times. Due to resurgence of ayurveda, utilization and consumption of herbal medicines is tremendously increasing leading to a significant percentage of the pharmaceutical market. The huge commercial benefits of herbal products are capturing the interest of pharmaceutical companies worldwide. Hence the safety and quality of medicinal plant materials and finished herbal medicinal products have become a major concern for health authorities, pharmaceutical industries as well as to the public. Presently, plenty of clinical trials are being conducted on herbal medicines; however, absence of harmonized classification has led to various confusions. The most important concern is the disputed identity of ayurvedic formulations sold under different brand names in different regions of the country and world. Recently, allopathic medicines have been classified by WHO on the basis of ATC/DDD (Anatomical- Therapeutic-Chemical/Daily Defined Dose) pattern of classification. The absence of such type of classification for ayurvedic products creates a situation of non recognition of these products in the international market. Hence there is a need to develop a classification system that is on the lines of ATC/DDD so that particular herb may qualify a product to be recognised under one name all over the world.Materials and Methods:Keeping in view the above scenario, a classification system is being proposed for ayurvedic products. The ayurvedic formulations and their site of action have been searched from various Ayurvedic texts. Internet sources such as Pubmed, Google Scholar, JSTOR etc.Results:The major reason for adopting similar classification for herbal medicines is that ayurvedic texts given by various scholars are published in Sanskrit or in the local/regional languages which make it difficult for the researchers to access, understand and interpret the knowledge shared.Conclusion:It is utmost important to generate such classification for herbal medicines as it will generate a classification data which can further be exploited for safety, efficacy as well as quality control purposes. Moreover, innovative classification will be helpful to provide standardized as well as a uniform way to classify the various herbal drugs and to generate new avenues for further ayurvedic research with more degree of precision. The classification will enable a product to be known under one banner/name at international level. Since the market is flooded with formulations related with neural disorders, hence herbal products used in neural disorders have been taken in the first phase.
Creación del Observatorio de Responsabilidad Social Educativa en América Latina
Authors: Martínez-Domínguez Luis-Manuel , Porto-Pedrosa Leticia 
Published: October 2018

Este artículo reflexiona sobre la importancia de crear en América Latina el Observatorio de Responsabilidad Social Educativa como entidad competente para analizar las prácticas que se llevan a cabo desde las instituciones educativas no universitarias y ofrecer asesoramiento para optimizarlas. A lo largo de las últimas décadas se han dado pasos importantes en esa búsqueda de la excelencia en el ámbito de la educación en diferentes países latinoamericanos. En cuanto a la educación universitaria, la responsabilidad social se considera un punto de partida indispensable para mejorar el impacto de estas instituciones en su comunidad y la sociedad en general, con la finalidad última de lograr una mejor formación para el desarrollo sostenible. Desde el Observatorio se promueve un ranking de instituciones educativas en el que se priorice este tipo de responsabilidad fundamentado en el debate, la reflexión y las buenas prácticas orientadas hacia esta nueva exigencia en las organizaciones y el bien común.
A kabai meteorit újravizsgálatának fontosabb eredményei
Authors: Kubovics Imre , Bendő Zsolt , Gál-Sólymos Kamilla , Ditrói-Puskás Zuárd , Miklós Dóra Georgina , Ivanics Balázs 
Published: October 2018

A kabai meteoritban többféle eredetű és összetételű hőálló (refraktorikus) ásvány, hőállóásvány-társulás mutatható ki. Legtöbbet és legjellegzetesebbeket a fehérzárványhalmazok, továbbá a kerekded–ovális kondrumszerű képződmények, valamint a 100–200 μm átmérőjű „kondrumok” tartalmaznak. A meteorit felszínén is látható – általában 10–18 mm hosszú – sárgásfehér „zárványokat” a mikroszkópi vizsgálatok szerint többnyire teljesen szabálytalan alakú, „szaggatott” szerkezetű, szemcsés halmazok alkotják. Helyenként egymás közvetlen közelében több különböző méretű halmazból álló csoport alakult ki, valószínűleg egy nagyobb darab széttöredezése eredményeképpen. A halmazok mozaikos szerkezete is ezzel magyarázható. Az uralkodóan 100–400 μm méretű, gyakran különböző összetételű, részben alapanyagot is tartalmazó szemcsék általában bonyolult zónás szerkezetűek. Leggyakoribb, illetve legnagyobb mennyiségű összetevője a magot alkotó, de kisebb mennyiségben rendszerint a többi övben is megjelenő közönséges spinell. A következő öveket részben gehlenit, de uralkodó mennyiségben, titánban és alumíniumban gazdag monoklin piroxének alkotják. Egyes szemcsék körül záró övként a forsterit is megjelenik.
A kerekded–ovális megjelenésű, kondrumszerű képződmények, valamint a kis méretű kondrumok az előzőekkel megközelítőleg, illetve részben azonos ásványi összetételűek, az alkotók mennyiségi arányában, valamint a képződési sorrendben azonban jelentős különbségek mutatkoznak. Az uralkodó magalkotó fázisok általában változó mennyiségű zárványt tartalmaznak. Például a gehlenitben rendszerint kevés perovszkit és részben spinell, a közönséges spinellben pedig többnyire sok perovszkit mutatható ki. Külön kiemelkedő a kerek „felhőszerű” halmaz magjának túlnyomó részét alkotó magnéziumtartalmú gehlenit nagy mennyiségű, mégpedig 72% platinát, továbbá — többek között — irídiumot és kevés hafniumot is tartalmazó „zárványa”. A kerekded–ovális képződményeken belül az alakzat, a szerkezet, valamint a jellemző ásványok alapján gehlenitet, közönséges spinellt, valamint normatív hercinitet és korundot tartalmazó változatot különböztethetünk meg. A jellemző uralkodó ásványok rendszerint az adott változat magját alkotják, és általában jelentős mennyiségű „zárványt” — főleg kerekded perovszkitot tartalmaznak. A mag körüli övezetet főleg spinell és monoklin piroxének alkotják. Egyes változatokban azonban az 5–7% Na2O-t tartalmazó — esetenként önálló övet alkotó — amorf anyag („mezosztázis”) is jelentős mennyiséget képvisel. Ez az öv valószínűleg a Mokoia-meteoritban kimutatott (MACPHERSON et al. 1983) filloszilikátokhoz hasonló összetételű (normatív) rétegszilikátokat is tartalmaz.
Középső-miocén sziláscet (Cetacea: Mysticeti) humerusok a Pécs, danitzpusztai homokbányából
Authors: Cserpák Ferenc 
Published: October 2018

Az utóbbi húsz év gyűjtéseinek köszönhetően nagy mennyiségű sziláscet felkarcsont került elő egyetlen lelőhelyről, a Pécs melletti danitzpusztai homokbányából. A vizsgált humerusok a középső-miocénből (szarmata, badeni?) áthalmozottan, a pannóniai homokban találhatók.
A területről összesen 19 db — kettő kivételével — közgyűjteményben elhelyezett humerust tanulmányoztam, melyek három taxonba sorolhatóak: cf. Cetotherium priscum (EICHWALD 1840); „Cetotherium” aff. maicopicum (SPASSKI 1951); és Cetotheriidae indet.
A danitzpusztai cf. C. priscumba sorolt felkarcsontokkal azonos taxont képviselnek a Pécs-Vasasról, a horvátországi Samoborról származó leletek, valamint a Bécsi-medence anyagából előkerült három példány.
A „Cetotherium” aff. maicopicum (SPASSKI 1951) egyedei méreteikben ugyan kisebbek, de morfológiai jellegeikben a Keleti-Paratethysből leírt „Cetotherium” maicopicum (SPASSKI 1951) felkarjával mutatnak nagyfokú egyezést, így azok feltehetően a genushoz tartozó új faj tagjai lehetnek.
A Cetotheriidae indet.-be sorolt kisméretű humerusnak nem sikerült megtalálni morfológiai és metrikus karaktereiben a párhuzamait, így nagy valószínűséggel egy új taxont képvisel.
Análisis de la nueva regulación del contrato menor en la Ley 9/2017, de 8 de noviembre, de Contratos del Sector Público
Authors: Carrodeguas Méndez Roberto 
Published: October 2018

En el Boletín Oficial de Estado número 272, del 9 de noviembre de 2017, se publicó la Ley de Contratos del Sector Público, entrando en vigor el pasado día 9 de marzo. Desde un primer momento, la configuración del contrato menor en la nueva Ley ha despertado un gran interés y preocupación, no solo entre los operadores jurídicos, sino también entre las propias empresas y profesionales que operan en el mercado. A pesar su corta vida, muchos son los interrogantes y dudas que ha generado el nuevo texto legal, proliferando opiniones doctrinales e informes de órganos consultivos en la materia con distinto criterio interpretativo, lo que ha provocado un elevado grado de inseguridad jurídica en el momento de aplicar la norma. Este trabajo pretende efectuar un estudio detallado de la figura del contrato menor y de su actual regulación normativa, analizando, desde un punto de vista práctico, las consecuencias que puede tener la nueva regulación en el ámbito de la Administración Pública. Por último, se exponen una serie de argumentos en defensa del contrato menor que conducen a la conclusión de que una correcta utilización del mismo puede resultar de gran utilidad en el ámbito de la contratación pública local.
n. 214 (18): Dor On Line
Authors: Barboni Paulo 
Published: October 2018

Caros leitores, essa edição de maio traz a vocês um editorial sobre o Ano Global da Excelência na Educação da Dor, promovido pela IASP. Temos também alertas de Divulgação Científica com temas sobro NGF e dor, terapia, educação e hipnose para a dor crônica, assim como o impacto da desta dor em distúrbios mentais. Temos também um alerta sobre o uso de Celecoxibe em grávidas. Na seção de Ciência e Tecnologia, temos alertas sobre a dor crônica e ressonância magnética funcional, tratamento da dor da gota, o papel da IL-6 na dor do câncer ósseo, o papel do canal Kcns1 na dor neuropática e do TLR4 na dor orofacial. Boa Leitura!
EDITORIAL DO MÊS
Editorial do mês
Ano Global da Excelência na Educação da Dor
Paulo Gustavo Barboni Dantas Nascimento

Divulgação Científica
1. Hiperalgesia que dura semanas. Fator de crescimento neural sensibiliza nociceptores na pele humana
Thayna Moreira Marra
2. Terapia de Aceitação e Comprometimento (TAC) para dor crônica realizada on-line é mediada pela flexibilidade psicológica. O uso da terapia online para o tratamento da dor crônica
Nycole Filincowsky Ribeiro
3. A educação da dor associada à hipnose clínica melhora a dor lombar crônica. “A orquestra do cérebro pode tocar uma música diferente”
Giovanna França Alves
4. Dor como um fator de risco para Transtornos Mentais. A dor como fator de risco para o surgimento e recorrência dos Transtornos Mentais
Marília Pereira da Silva
5. Celecoxibe, quando utilizado no último trimestre de gestação, eleva o risco de parto prematuro. Estudo clínico canadense mostra evidências
Eliane Vieira Rosa
6. A conectividade cerebral em modelo de dor crônica. Imagens por ressonância magnética funcional demostram reorganizações cerebrais em estado de dor crônica
Ivo Vieira de Sousa Neto
7. Efeitos do ácido hialurônico sobre a atividade neuronal e dor articular em modelo animal com gota aguda. Diminuição do comportamento doloroso da gota aguda?
Karenina Guida
8. Bloqueio da sinalização da interleucina-6 modifica câncer ósseo. A descoberta terapêutica que impacta a progressão do câncer ósseo e promove o controle da dor
Jhonata da Cruz Matos
9. Sensibilidade aumentada a dor neuropática em camundongos deficientes para o canal de potássio voltagem dependente Kcns1. Estudo demonstra importante regulador da dor
Larissa Garcia Pinto
10. A deficiência de TLR4 reduz a alodinia mecânica generalizada. TLR4 participam na dor disseminada da região orofacial para locais distantes do corpo
Erika Ivanna Araya Pallarés