bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Two Different Methods for Pain Reduction During Insulin Injection in Children With Type 1 Diabetes: Buzzy and ShotBlocker
Authors: Canbulat Sahiner Nejla , Turkmen Ayse Sonay , Acikgoz Ayfer , Simsek Enver , Kirel Birgul 
Published: October 2018

AbstractBackgroundRepeated injections may prevent children from performing insulin administration (skip dosing) and may cause anxiety.AimsTo compare the effect of ShotBlocker and the combination of vibration and cold application (Buzzy) in reducing pain during insulin administration in children.MethodsThis research was designed as a randomized controlled experimental study. The study sample consisted of 60 children aged between 6 and 12 years who were diagnosed as having type 1 diabetes and received insulin from the Child Endocrinology Department of the medical faculty in Eskisehir Osmangazi University between May 2015 and June 2017. The children were randomized into the Buzzy (n = 20), ShotBlocker (n = 20), and control (n = 20) groups. Three instruments were used to obtain the research data: Interview and Observation Form, Children's Anxiety and Pain Scale (CAPS), and Faces Pain Scale—Revised (FPS‐R).ResultsThe mean age of the children was 9.43 ± 2.18 years (range 6–12 years). There were no significant differences among preprocedural anxiety levels of the study groups in terms of self‐, parent‐, and observer‐reported levels (p = .935, p = .374, and p = .680, respectively). Children in the control group had higher levels of pain than children in the Buzzy and ShotBlocker groups (p = .008, p = .007, and p > .001, respectively). There was a significant difference between the groups with procedural anxiety levels reported by the family and observer (p = .006 and p = .002, respectively), favoring the intervention groups.Linking Evidence to ActionNurses should be aware of pain during insulin injection and use methods for pain relief accordingly. ShotBlocker is recommended as a helpful option in cases where a pain control method is required.
Identifying health policy and systems research priorities on multisectoral collaboration for health in low-income and middle-income countries
Authors: Glandon Douglas , Meghani Ankita , Jessani Nasreen , Qiu Mary , Bennett Sara 
Published: October 2018

IntroductionWhile efforts to achieve Universal Health Coverage (UHC) and the Sustainable Development Goals (SDGs) have reinvigorated interest in multisectoral collaborations (MSCs) among the global health and development community, there remains a plethora of questions about how best to conceptualise, plan, implement, evaluate and sustain MSCs. The objective of this paper is to present research priorities on MSC for health from researchers and policymakers around the globe, with an emphasis on low-income and middle-income countries.MethodsThe authors identified 30 priority research questions from two sources: (1) 38 review articles on MSC for health, and (2) interviews and focus groups with a total of 81 policymakers, including government officials (largely from ministries of health and state/provincial departments of health, but also offices of planning, public service, social development, the prime minister and others), large multilateral or bilateral organisations, and non-governmental organisations. In a third phase, questions were refined and ranked by a diverse group of researchers from around the globe using an online voting platform.ResultsThe top-ranked questions focused predominantly on pragmatic questions, such as how best to structure, implement and sustain MSCs, as well as how to build stakeholder capacity and community partnerships. Despite substantial variation between review articles, policymakers’ reflections and online ranking by researchers, two topics emerged as research priorities for all three: (1) leadership, partnership and governance structures for MSCs; and (2) MSC implementation strategies and mechanisms. The review articles underscored the need for more guidance on appropriate study designs and methods for investigating MSCs, which may be a prerequisite for other identified research priorities.ConclusionThese findings could inform efforts within and beyond the health sector to better align research objectives and funding with the evidence needs of policymakers grappling with questions about how best to leverage MSCs to achieve UHC and the SDGs.
No surge in illicit cigarettes after implementation of menthol ban in Nova Scotia
Authors: Stoklosa Michal 
Published: October 2018

BackgroundIn May 2015, the Canadian province of Nova Scotia became the first jurisdiction in the world to ban menthol cigarettes specifically. The tobacco industry warned that ‘the primary effect of this law will be to increase the illegal tobacco market in Nova Scotia’. This is the first attempt to examine the impact of the menthol ban on trends in illicit cigarettes.Data and methodsData on the number of illicit cigarettes seized in Nova Scotia covering the period from 2007/2008 to 2017/2018 was obtained from the Provincial Tax Commission. Data from before and after the ban are compared.ResultsAccording to the local authorities, while the enforcement efforts in Nova Scotia have not declined, the number of seized illicit cigarettes declined significantly, from >60 000 cartons in 2007/2008 to <10 000 cartons in 2017/2018. Since the menthol ban, the seizure volume remained stable, with no statistically significant difference in the number of cigarettes seized before and after the menthol ban (t=−0.71, p=0.55). There were only a few small seizures of menthol cigarettes in the year following the ban, after which there have been no further seizures of menthol cigarettes.DiscussionContrary to the tobacco industry’s assertions, there was no surge in illicit cigarettes after the 2015 ban on menthol cigarette sales in Nova Scotia. Credible, industry-independent evidence on illicit cigarette trade is desperately needed to support the implementation of tobacco control policies.
Enhanced gastrointestinal passive paracellular permeability contributes to the obesity-associated hyperoxaluria
Authors: Bashir Mohamed , Meddings Jon , Alshaikh Altayeb , Jung Daniel , Le Kim , Amin Ruhul , Ratakonda Sireesha , Sharma Sapna , Granja Ignacio , Satti Mustafa , Asplin John , Hassan Hatim 
Published: October 2018

Most kidney stones (KS) are composed of calcium oxalate and small increases in urine oxalate enhance the stone risk. Obesity is a risk factor for KS, and urinary oxalate excretion increases with increased body size. We previously established the obese ob/ob ( ob) mice as a model (3.3-fold higher urine oxalate) to define the pathogenesis of obesity-associated hyperoxaluria (OAH). The purpose of this study was to test the hypothesis that the obesity-associated enhanced small intestinal paracellular permeability contributes to OAH by increasing passive paracellular intestinal oxalate absorption. ob Mice have significantly higher jejunal (1.6-fold) and ileal (1.4-fold) paracellular oxalate absorption ex vivo and significantly higher (5-fold) urine [13C]oxalate following oral gavage with [13C]oxalate, indicating increased intestinal oxalate absorption in vivo. The observation of higher oxalate absorption in vivo compared with ex vivo suggests the possibility of increased paracellular permeability along the entire gut. Indeed, ob mice have significantly higher fractions of the administered sucrose (1.7-fold), lactulose (4.4-fold), and sucralose (3.1-fold) excreted in the urine, reflecting increased gastric, small intestinal, and colonic paracellular permeability, respectively. The ob mice have significantly reduced gastrointestinal occludin, zonula occludens-1, and claudins-1 and -3 mRNA and total protein expression. Proinflammatory cytokines and oxidative stress, which are elevated in obesity, significantly enhanced paracellular intestinal oxalate absorption in vitro and ex vivo. We conclude that obese mice have significantly higher intestinal oxalate absorption and enhanced gastrointestinal paracellular permeability in vivo, which would likely contribute to the pathogenesis of OAH, since there is a transepithelial oxalate concentration gradient to drive paracellular intestinal oxalate absorption. NEW & NOTEWORTHY This study shows that the obese ob/ob mice have significantly increased gastrointestinal paracellular oxalate absorption and remarkably enhanced paracellular permeability along the entire gut in vivo, which are likely mediated by the obesity-associated increased systemic and intestinal inflammation and oxidative stress. A transepithelial oxalate concentration gradient driving gastrointestinal paracellular oxalate absorption exists, and therefore, our novel findings likely contribute to the hyperoxaluria observed in the ob/ob mice and hence to the pathogenesis of obesity-associated hyperoxaluria.
FDA Approval Summary: Tisagenlecleucel for Treatment of Patients with Relapsed or Refractory B-cell Precursor Acute Lymphoblastic Leukemia
Authors: O'Leary Maura C. , Lu Xiaobin , Huang Ying , Lin Xue , Mahmood Iftekhar , Przepiorka Donna , Gavin Denise , Lee Shiowjen , Liu Ke , George Bindu , Bryan Wilson , Theoret Marc R. , Pazdur Richard 
Published: October 2018

Abstract
Tisagenlecleucel (Kymriah; Novartis Pharmaceuticals) is a CD19-directed genetically modified autologous T-cell immunotherapy. On August 30, 2017, the FDA approved tisagenlecleucel for treatment of patients up to 25 years of age with B-cell precursor acute lymphoblastic leukemia (ALL) that is refractory in second or later relapse. Approval was based on the complete remission (CR) rate, durability of CR, and minimal residual disease (MRD) &lt;0.01% in a cohort of 63 children and young adults with relapsed or refractory ALL treated on a single-arm trial (CCTL019B2202). Treatment consisted of fludarabine and cyclophosphamide followed 2 to 14 days later by a single dose of tisagenlecleucel. The CR rate was 63% (95% confidence interval, 50%–75%), and all CRs had MRD &lt;0.01%. With a median follow-up of 4.8 months, the median duration of response was not reached. Cytokine release syndrome (79%) and neurologic events (65%) were serious toxicities reported in the trial. With implementation of a Risk Evaluation and Mitigation Strategy, the benefit–risk profile was considered acceptable for this patient population with such resistant ALL. A study of safety with 15 years of follow-up is required as a condition of the approval.
See related commentary by Geyer, p. 1133
ProDiet: A Phase II Randomized Placebo-controlled Trial of Green Tea Catechins and Lycopene in Men at Increased Risk of Prostate Cancer
Authors: Lane J. Athene , Er Vanessa , Avery Kerry N.L. , Horwood Jeremy , Cantwell Marie , Caro Gema P. , Crozier Alan , Smith George Davey , Donovan Jenny L. , Down Liz , Hamdy Freddie C. , Gillatt David , Holly Jeff , Macefield Rhiannon , Moody Hilary , Neal David E. , Walsh Eleanor , Martin Richard M. , Metcalfe Chris 
Published: October 2018

Abstract
Epidemiologic studies suggest that diet can alter prostate cancer risk. This study aimed to establish the feasibility and acceptability of dietary modification in men at increased risk of prostate cancer. Men were invited with a PSA level of 2.0–2.95 ng/mL or 3.0–19.95 ng/mL with negative prostate biopsies. Randomization (3 × 3 factorial design) to daily green tea and lycopene: green tea drink (3 cups, unblinded) or capsules [blinded, 600 mg flavan-3-ol ()-epigallocatechin-3-gallate (EGCG) or placebo] and lycopene-rich foods (unblinded) or capsules (blinded, 15 mg lycopene or placebo) for 6 months. Primary endpoints were randomization rates and intervention adherence (blinded assessment of metabolites) at 6 months with secondary endpoints of acceptability (from interviews), safety, weight, blood pressure, and PSA. A total of 133 of 469 (28.4%) men approached agreed to be randomized and 132 were followed-up (99.2%). Mean lycopene was 1.28 [95% confidence intervals (CI), 1.09–1.50, P = 0.003] times higher in the lycopene capsule group and 1.42 (95% CI, 1.21–1.66; P &lt; 0.001) times higher in the lycopene-enriched diet group compared with placebo capsules. Median EGCG was 10.7 nmol/L (95% CI, 7.0–32.0) higher in in the active capsule group and 20.0 nmol/L (95% CI, 0.0–19.0) higher in the green tea drink group compared with placebo capsules (both P &lt; 0.001). All interventions were acceptable and well tolerated although men preferred the capsules. Dietary prevention is acceptable to men at risk of prostate cancer. This intervention trial demonstrates that a chemoprevention clinical trial is feasible. Cancer Prev Res; 11(11); 687–96. ©2018 AACR.
Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix
Authors: Gollmann‐Tepeköylü Can , Lobenwein Daniela , Theurl Markus , Primessnig Uwe , Lener Daniela , Kirchmair Elke , Mathes Wolfgang , Graber Michael , Pölzl Leo , An Angela , Koziel Katarzyna , Pechriggl Elisabeth , Voelkl Jakob , Paulus Patrick , Schaden Wolfgang , Grimm Michael , Kirchmair Rudolf , Holfeld Johannes 
Published: October 2018

Background

Mechanical stimulation of acute ischemic myocardium by shock wave therapy (
SWT
) is known to improve cardiac function by induction of angiogenesis. However,
SWT
in chronic heart failure is poorly understood. We aimed to study whether mechanical stimulation upon
SWT
improves heart function in chronic ischemic heart failure by induction of angiogenesis and postnatal vasculogenesis and to dissect underlying mechanisms.

Methods and Results

SWT
was applied in a mouse model of chronic myocardial ischemia. To study effects of
SWT
on postnatal vasculogenesis, wild‐type mice received bone marrow transplantation from green fluorescence protein donor mice. Underlying mechanisms were elucidated in vitro in endothelial cells and murine aortic rings. Echocardiography and pressure/volume measurements revealed improved left ventricular ejection fraction, myocardial contractility, and diastolic function and decreased myocardial fibrosis after treatment. Concomitantly, numbers of capillaries and arterioles were increased.
SWT
resulted in enhanced expression of the chemoattractant stromal cell–derived factor 1 in ischemic myocardium and serum. Treatment induced recruitment of bone marrow–derived endothelial cells to the site of injury. In vitro,
SWT
resulted in endothelial cell proliferation, enhanced survival, and capillary sprouting. The effects were vascular endothelial growth factor receptor 2 and heparan sulfate proteoglycan dependent.

Conclusions

SWT
positively affects heart function in chronic ischemic heart failure by induction of angiogenesis and postnatal vasculogenesis.
SWT
upregulated pivotal angiogenic and vasculogenic factors in the myocardium in vivo and induced proliferative and anti‐apoptotic effects on endothelial cells in vitro. Mechanistically, these effects depend on vascular endothelial growth factor signaling and heparan sulfate proteoglycans.
SWT
is a promising treatment option for regeneration of ischemic myocardium.
Migrant Waste Collectors in Thailand’s Informal Economy
Authors: Campbell Stephen 
Published: October 2018

Abstract
Recent scholarship on primitive accumulation and deagrarianisation in the global South has addressed a decline in formal employment prospects, leaving most ex-peasants (and their heirs) struggling to earn a livelihood in the informal economy. Taking this phenomenon as a point of departure, and drawing on the case of migrant waste collectors in Mae Sot, Thailand, this article examines the multiple ways that waste collectors are embedded in informal relations of production and exchange. This variable relational embeddedness has implications, it is argued, for the forms of struggle available to those engaged in informal labour.
Rapid Intensification of Typhoon Mujigae (2015) under Different Sea Surface Temperatures: Structural Changes Leading to Rapid Intensification
Authors: Chen Xiaomin , Xue Ming , Fang Juan 
Published: October 2018

Abstract
The notable prelandfall rapid intensification (RI) of Typhoon Mujigae (2015) over abnormally warm water with moderate vertical wind shear (VWS) is investigated by performing a set of full-physics model simulations initialized with different sea surface temperatures (SSTs). While all experiments can reproduce RI, tropical cyclones (TCs) in cooler experiments initiate the RI 13 h later than those in warmer experiments. A comparison of structural changes preceding RI onset in two representative experiments with warmer and cooler SSTs (i.e., CTL and S1) indicates that both TCs undergo similar vertical alignment despite the moderate VWS. RI onset in CTL occurs ~8 h before the full vertical alignment, while that in S1 occurs ~5 h after. In both experiments precipitation becomes more symmetrically distributed around the vortex as vortex tilt decreases. In CTL, precipitation symmetricity is higher in the inner-core region, particularly for stratiform precipitation. All experiments indicate that RI onset occurs when the radius of maximum wind (RMW) contraction reaches a certain degree measured in terms of local Rossby number. The contraction occurs much earlier in CTL, leading to earlier RI. These results suggest that vertical alignment, albeit necessary, is not an effective RI indicator under different SSTs, while a more immediate cause of RI is the formation of a strong/compact inner core with high precipitation symmetry. Diagnoses using the Sawyer–Eliassen equation indicate that in CTL the enhanced microphysical diabatic heating of additional midlevel and deep convection along with surface friction contribute to stronger boundary layer inflow near/inside the RMW, facilitating earlier RMW contraction.
Sensitivity of Tropical Cyclone Intensification to Axisymmetric Heat Sources: The Role of Low-Level Heating and Cooling from Different Microphysical Processes
Authors: Paull Georgina , Menelaou Konstantinos , Yau M. K. 
Published: October 2018

Abstract
Latent heat release from condensational heating has been recognized as one of the dominating energy sources of a tropical cyclone. Here we argue that other microphysical processes may also play an important role. From an analysis of a real-case simulation of Hurricane Katrina (2005), it was found that cooling from evaporation and melting of some frozen hydrometeors radially outside the eyewall region can have similar magnitudes as condensational heating. Based on this finding, idealized thermally forced experiments were performed. The specified heating and cooling functions mimic those found in the Hurricane Katrina run. The results indicated that the addition of cooling enhances the lower-level inward radial winds, which in turn increases the acceleration of the lower-level tangential winds through an enhanced transport of absolute vorticity. Sensitivity experiments on varying the structure of the cooling functions and the background state of the vortex demonstrate that the lower-level tangential wind acceleration is more sensitive to changes in the vertical structure and location of the cooling than the radial characteristics. In addition, the lower-level acceleration is sensitive to variations in the inertial and static stabilities rather than the vertical tangential wind shear of the initial vortex and its environment.
Probabilistic Skill of Subseasonal Precipitation Forecasts for the East Africa–West Asia Sector during September–May
Authors: Vigaud N. , Tippett M. K. , Robertson A. W. 
Published: October 2018

Abstract
The skill of submonthly forecasts of rainfall over the East Africa–West Asia sector is examined for starts during the extended boreal winter season (September–April) using three ensemble prediction systems (EPSs) from the Subseasonal-to-Seasonal (S2S) project. Forecasts of tercile category probabilities over the common period 1999–2010 are constructed using extended logistic regression (ELR), and a multimodel forecast is formed by averaging individual model probabilities. The calibration of each model separately produces reliable probabilistic weekly forecasts, but these lack sharpness beyond a week lead time. Multimodel ensembling generally improves skill by removing negative skill scores present in individual models. In addition, the multimodel ensemble week-3–4 forecasts have a higher ranked probability skill score and reliability compared to week-3 or week-4 forecasts for starts in February–April, while skill gain is less pronounced for other seasons. During the 1999–2010 period, skill over continental subregions is the highest for starts in February–April and for starts during El Niño conditions and MJO phase 7, which coincides with enhanced forecast probabilities of above-normal rainfall. Overall, these results indicate notable opportunities for the application of skillful subseasonal predictions over the East Africa–West Asia sector during the extended boreal winter season.
Cerebellar volume in early-onset schizophrenia and its association with severity of symptoms
Authors: Özbek Aylin , Göçmen Mas Nüket , Turan Serkan , Ay Bari , Serim Demirgören Burcu , Nilüfer Yonguç Gökşin , Karabekir Selim , İpek Polat Ayşe , Semra Hız Ayşe , Gencer Kıdak Özlem 
Published: October 2018

Objectives This study aimed to investigate whether early-onset schizophrenia (EOS) cases differ from controls regarding volumes of the total cerebellum and the right and left cerebellar hemispheres, and volumetric asymmetry. Correlations of cerebellar volumes and asymmetry indices with severity of symptoms and general functioning in cases of EOS were also assessed. Methods Adolescents with EOS (n = 23) were compared with controls (n = 23). Sociodemographic and clinical data, and magnetic resonance imaging scans that were acquired for routine clinical purposes were collected retrospectively. Cerebellar volumes were evaluated using the stereological method. Asymmetry indices were subsequently calculated. Scores of the Positive and Negative Syndrome Scale and the Children’s Global Assessment Scale were used to assess the severity of symptoms and general functionality. Results There were no significant differences in any of the cerebellar volumes and asymmetry indices between the two groups. Neither cerebellar volumes nor asymmetry indices were correlated with the severity of symptoms and general functionality in EOS. Conclusions Our findings suggest that the early-onset form of schizophrenia does not show apparent volumetric changes of the cerebellum. Additionally, the neural circuits involved in formation of symptomatology may not reflect any correlation with cerebellar volumes at mid-adolescence.