bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and echocardiographic presentation of postmyocardial infarction papillary muscle rupture
Authors: Leroux Émilie , Chauvette Vincent , Voisine Pierre , Dagenais François , Charbonneau Éric , Beaudoin Jonathan , Dubois‐Sénéchal Élie , Dubois Michelle , Sénéchal Mario 
Published: June 2019

AbstractBackgroundSevere mitral regurgitation (MR) can occur following myocardial infarction (MI) with either partial or complete papillary muscle rupture (pPMR or cPMR). Although the incidence of this complication has significantly decreased, it is still associated with significant mortality. We sought to evaluate the different echocardiographic and clinical presentations of pPMR and cPMR.Methods and ResultsA review of all the urgent procedures for ischemic MR between January 2000 and June 2016 was performed to identify patients who underwent surgery for PMR. Surgical protocols and echocardiographic studies were used to identify patients with cPMR and pPMR. A total of 37 patients had cardiac surgery for PMR (18 cPMR, 19 pPMR). All patients with cPMR were in cardiogenic shock at the time of diagnosis, as opposed to only 53% of patients with pPMR (P = 0.0008). Between the time of diagnosis and surgery, 7 patients with pPMR developed cardiogenic shock. Transthoracic echocardiography (TTE) led to the diagnosis in 72% of cPMR and 32% of pPMR (P = 0.02). TEE had a yield of 100% for both cPMR and pPMR. Six pathologic varieties of post‐MI PMR were recognized on echocardiography and during surgery. Early postoperative, 1 (72% vs 84%), 3 (67% vs 84%), and 5 years (67% vs 74%) survival rates were similar for cPMR and pPMR (P = 0.26).ConclusionsPartial PMR is associated with a different clinical and echocardiographic presentation than cPMR. Still, most pPMR patients progress toward cardiogenic shock. Prompt diagnosis and referral for surgery are critical and could potentially decrease mortality.
Echocardiographic mimicker of thrombus on a mechanical aortic valve prosthesis due to cavitation: A paradoxical phenomenon of pressure recovery
Authors: Wang Zhenzhen , Ayoub Chadi , Thaden Jeremy J. , Alsidawi Said , Miller Fletcher A. , Sinak Lawrence J. , Rihal Charanjit S. , Melduni Rowlens M. 
Published: June 2019

AbstractWe describe a case of a mass‐like echocardiographic density on a mechanical prosthetic aortic valve. We initially suspected a thrombus vs vegetation on transthoracic echocardiography, but after transesophageal echocardiography, the density was subsequently determined to be cavitation by reviewing the initial images in slow motion.
Distribution of Bemisia tabaci within soybean plants and on individual leaflets
Authors: Pozebon Henrique , Cargnelutti Filho Alberto , Guedes Jerson V.C. , Ferreira Dener R. , Marques Rafael P. , Bevilaqua Júlia G. , Patias Leonardo S. , Colpo Tiago L. , Arnemann Jonas A. 
Published: June 2019

AbstractTo control whiteflies on soybean crops in an effective and economically viable way, it is necessary to quantify the occurrence and density of Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) on the leaflets. Estimating the number of B. tabaci cm‐2 on leaflets is difficult, because its distribution pattern on the various parts of the plant canopy and on the leaflet surface is unknown. The aim of this study was to evaluate the distribution of B. tabaci nymphs on soybean plants and leaflets, under greenhouse and field conditions. One hundred soybean plants infested with all nymph stages were randomly selected in a greenhouse, and 25 in a field. Of each plant, a trifoliate leaf of the middle third of the plant’s height was selected and its central leaflet was collected (greenhouse experiment), or a trifoliate leaf of each third layer (upper, middle, and lower), of which the left, central, and right leaflets were collected (field experiment). The collected leaflets were divided into 32 sections (1 cm2 per section), arranged in an array of eight rows and four columns to count whitefly nymphs. The Morisita index (Iδ), the negative binomial parameter k, and the dispersion index (I) were calculated for each leaflet, using the number of nymphs as variable. The highest population densities of whitefly nymphs were found in the middle third of the soybean plants. In leaflets from the middle third, the nymphs concentrated in the middle and bottom parts of the leaflets, whereas in the upper and lower thirds of the plant, they were randomly distributed on the leaflets.
Observational evidence from patients diagnosed with chronic lymphocytic leukaemia (CLL) in Finland between 2005‐2015 show improved survival over time
Authors: Lindström Vesa , Hakkarainen Katja M. , Mehtälä Juha , Klement Riho , Leval Amy , Järvinen Tiina M. 
Published: June 2019

AbstractObjectivesWe aimed to describe treatment patterns of chronic lymphocytic leukaemia (CLL) patients in routine practice settings, compare overall survival and time‐to‐next‐treatment among patients treated in different time periods (2005‐2008, 2009‐2013, 2014‐2015), and explore associated factors.MethodsThis retrospective cohort study included adult CLL patients from the Finnish Hematology Registry.ResultsIn total, 124 and 64 CLL patients received first‐ and second‐line treatments, respectively. The use of first‐ and second‐line treatments with bendamustine‐rituximab (BR) increased, while chlorambucil‐based treatments decreased over time. Patients treated in more recent years showed a trend towards longer first‐ and second‐line survival. A trend towards inferior overall survival was detected in first‐ and second‐line treatment with B/BR. First‐line time‐to‐next‐treatment was longer for patients treated in the later years towards 2015, while second‐line time‐to‐next‐treatment did not improve over time.ConclusionsThis study identified that improved treatment outcomes over time were likely influenced by patient characteristics and treatments, but also through other factors unexplored in this study. Hence, further research on the factors influencing patients’ survival over time is needed. In particular, research on using B/BR in clinical practice is warranted.
The tumour microenvironment is immuno‐tolerogenic and a principal determinant of patient outcome in EBV‐positive diffuse large B‐cell lymphoma
Authors: Keane Colm , Tobin Joshua , Gunawardana Jay , Francis Santiyagu , Gifford Grace , Gabrielli Sara , Gill Anthony , Stevenson William , Talaulikar Dipti , Gould Clare , Jain Sanjiv , Birch Simone , Hertzberg Mark , Gandhi Maher K. 
Published: June 2019

AbstractObjectiveEpstein‐Barr virus‐positive diffuse large B‐cell lymphoma (EBV‐pos DLBCL) is a recently identified entity. Data regarding outcome to frontline immuno‐chemotherapy are conflicting. Although the prognostic impact of the tumour microenvironment (TME) in EBV‐neg DLBCL is well‐established, it remains untested whether the TME influences survival in EBV‐pos DLBCL. There are no data with new digital gene expression technologies that simultaneously interrogate the virus, B cells and the tumour microenvironment (TME).MethodsWe used the NanoString™ platform in a population‐based cohort of 433 patients to establish if the technology could detect EBV in the tumour biopsies and to investigate the influence that EBV has on the complex tumour microenvironment of DLBCL.ResultsIncidence of EBV‐pos DLBCL was 6.9% with 5‐year survival of 65% vs 82% in EBV‐neg DLBCL (P = 0.018). EBV‐pos tissues had similar expression of T‐cell genes compared to EBV‐neg DLBCL but higher levels of the antigen‐presenting molecule B2M. This was countered by elevated PD‐L1, PD‐L2, LAG3 and TIM3 immune checkpoints and a higher CD163/CD68 “M2” macrophage score.ConclusionIn EBV‐pos DLBCL, the TME is immuno‐tolerogenic and may explain the poor outcomes seen in this subtype of DLBCL.
Fatal disseminated enterovirus infection in a patient with follicular lymphoma undergoing obinutuzumab maintenance therapy
Authors: Heger Jan‐Michel , Eichenauer Dennis A. , Kasper Philipp , Böll Boris , Shimabukuro‐Vornhagen Alexander , Kochanek Matthias 
Published: June 2019

AbstractFollicular lymphoma is the most common subtype of the indolent non‐Hodgkin lymphomas. Treatment usually consists of immuno‐chemotherapy and results in long‐lasting remissions in most cases. Progression‐free survival with the second‐generation anti‐CD20 antibody obinutuzumab was shown to be better than with rituximab when given in combination with either bendamustine or anthracycline‐based chemotherapy. Although treatment is generally well tolerated without an excessive rate of toxicities, there appear to be slightly more adverse events with obinutuzumab than with rituximab. Here, we report the case of a 45‐year‐old female patient that was diagnosed with a disseminated enterovirus infection while undergoing maintenance therapy with obinutuzumab after induction treatment with the combination of bendamustine and rituximab. Enterovirus RNA was detected in the blood, the cerebrospinal fluid, and the colon. A therapy with intravenous immunoglobulins was initiated since the patient presented with a severe treatment‐related immunosuppression indicated by hypogammaglobulinemia. Nonetheless, she eventually died from the enterovirus infection without evidence of lymphoma progression. This case underscores that clinicians should be aware of rare but potentially fatal infectious complications related to treatment protocols containing anti‐CD20 antibodies.
The demographic effects of functional traits: an integral projection model approach reveals population‐level consequences of reproduction‐defence trade‐offs
Authors: Struckman Soren , Couture John J. , LaMar M. Drew , Dalgleish Harmony J. 
Published: June 2019

AbstractQuantitatively linking individual variation in functional traits to demography is a necessary step to advance our understanding of trait‐based ecological processes. We constructed a population model for Asclepias syriaca to identify how functional traits affect vital rates and population growth and whether trade‐offs in chemical defence and demography alter population growth. Plants with higher foliar cardenolides had lower fibre, cellulose and lignin levels, as well as decreased sexual and clonal reproduction. Average cardenolide concentrations had the strongest effect on population growth. In both the sexual and clonal pathway, the trade‐off between reproduction and defence affected population growth. We found that both increasing the mean of the distribution of individual plant values for cardenolides and herbivory decreased population growth. However, increasing the variance in both defence and herbivory increased population growth. Functional traits can impact population growth and quantifying individual‐level variation in traits should be included in assessments of population‐level processes.
A potential role of hypophosphatemia for diagnosing convulsive seizures: A case‐control study
Authors: Barras Pierre , Siclari Francesca , Hügli Olivier , Rossetti Andrea O. , Lamy Olivier , Novy Jan 
Published: June 2019

AbstractObjectiveTransient loss of consciousness (TLOC) is a common presentation in the emergency room, where patient history can usually differentiate syncope from generalized tonic‐clonic (GTC) seizures. Several serum markers, such as creatine kinase and lactate, can be helpful, especially when history is unreliable. Here, we explore a potential supporting role of electrolyte plasma levels in a case‐control study.MethodsIn our electroencephalographic database, we retrospectively identified consecutive episodes of loss of consciousness in adults seen over 3 years in our hospital emergency department for a case‐control study. We investigated plasma levels of several electrolytes (sodium, potassium, phosphate, calcium, magnesium) at the emergency visit, as well as demographics, diagnosis, blood‐sample delay time, and history of alcohol abuse.ResultsOf the 126 patients identified, 75 had GTC seizures and 46 had other TLOC causes. Among electrolyte levels, only hypophosphatemia was associated with GTC seizures (median = 0.79 mmol·L–1, range = 0.34‐1.37 in GTC seizures vs 0.93 mmol·L–1, range = 0.52‐1.56, P = 0.001 in TLOC). After adjusting for blood sampling delay, alcohol abuse, and other electrolyte levels, only hypophosphatemia was associated with GTC seizures, occurring in 37 (51%) of GTC seizures and 12 (22%) of other TLOC (odds ratio = 3.5, 95% confidence interval = 1.5‐8.3, P = 0.003). Hypophosphatemia < 0.6 mmol·L–1 was 93% specific and 20% sensitive for GTC seizure occurrence. In follow‐ups, hypophosphatemia was transitory.SignificanceTransient hypophosphatemia is common after GTC seizures and could represent an additional biological marker to help differentiate GTC seizures from other TLOC, especially when history is unclear. This hypothesis needs to be tested prospectively.
First record of the mealybug Phenacoccus madeirensis Green, 1923 (Hemiptera: Coccomorpha: Pseudococcidae) in Algeria
Authors: Guenaoui Y. , Watson G. W. , Labdaoui Z. E. 
Published: June 2019

The mealybug Phenacoccus madeirensis Green (Hemiptera: Coccomorpha: Pseudococcidae) is recorded from Algeria for the first time. This pest was first detected in the summer of 2018 in private gardens in Salamandre, on the coastal side of Mostaganem City in north‐western Algeria, feeding on three ornamental plants: Hibiscus rosa‐sinensis L., Hibiscus syriacus L. (Malvaceae) and Cestrum nocturnum L. (Solanaceae). In October 2018, it was also found on Aloysia citriodora Palàu (Verbenaceae) growing near Hibiscus. The first samples collected had been attacked by hymenopteran parasitoids. Surveys of ornamental nurseries and greenhouses growing vegetables in the area indicate that, at present, P. madeirensis seems to be restricted to ornamental plants. More surveys over larger areas are needed to determine its distribution and the likely origin of its introduction to Algeria.
Caudal cervical vertebral morphological variation is not associated with clinical signs in Warmblood horses
Authors: Veraa S. , de Graaf K. , Wijnberg I. D. , Back W. , Vernooij H. , Nielen M. , Belt A.J. M. 
Published: June 2019

SummaryBackgroundVariation in equine caudal cervical spine morphology at C6 and C7 has high prevalence in Warmblood horses and is suspected to be associated with pain in a large mixed‐breed group of horses. At present no data exist on the relationship between radiographic phenotype and clinical presentation in Warmblood horses in a case‐control study.ObjectivesTo establish the frequency of radiographically visible morphologic variation in a large group of Warmblood horses with clinical signs and compare this with a group without clinical signs. We hypothesised that occurrence of morphologic variation in the case group would not differ from the control group, indicating there is no association between clinical signs and morphologic variation.Study designRetrospective case‐control.MethodsRadiographic presence or absence of morphologic variation of cervical vertebrae C6 and C7 was recorded in case (n = 245) and control horses (n = 132). Case and control groups were compared by univariable Pearson’s Chi‐square and multivariable logistic regression for measurement variables age, sex, breed, degenerative joint disease and morphologic variation at C6 and C7. Odds ratio and confidence intervals were obtained. A P≤0.05 was considered statistically significant.ResultsMorphologic variation at C6 and C7 (n = 108/377 = 28.6%; Cases 58/245 = 23.7%; Control 50/132 = 38%) was less frequent in horses with clinical signs in univariable testing (OR 0.48, 95% CI 0.3–0.8, P = 0.001). Age, sex, breed and degenerative joint disease were not retained in the final multivariable logistic regression step whereas morphologic variation remained significantly less present in horses with clinical signs.Main limitationsPossible demographic differences between equine clinics.ConclusionsMorphologic variation in the caudal cervical spine was detected more frequently in horses without clinical signs. Therefore, radiographic presence of such variation does not necessarily implicate the presence of clinical signs.
Grid quorum‐based spatial coverage in mobile wireless sensor networks using nature‐inspired firefly algorithm
Authors: Eldrandaly Khalid , Abdel‐Basset Mohamed , Abdel‐Fatah Laila 
Published: June 2019

AbstractOptimization and design of mobile wireless sensor networks (MWSNs) must assure adequate spatial coverage of the site. The spatial coverage optimization aims to enrich discoverability of MWSN by specifying mobile sensors geographical locations in order to maximize their coverage. In this paper, an enhanced metaheuristic algorithm called “firefly algorithm with crossover and detection phases” is introduced for optimizing the area coverage percentage of MWSN. The proposed algorithm is tested on many datasets with different criterions and compared with other algorithms including differential evolution, whale optimization algorithm, and flower pollination algorithm. The experimental results are analysed with one‐way ANOVA test. In addition, the proposed algorithm is compared with particle swarm optimization, and the results are analysed with Wilcoxon signed‐rank test. The overall analysis results prove the prosperity and efficient exploration of the proposed algorithm.
High‐cycle and very‐high‐cycle fatigue behaviour of a titanium alloy with equiaxed microstructure under different mean stresses
Authors: Pan Xiangnan , Hong Youshi 
Published: June 2019

AbstractThe fatigue behaviour of a titanium alloy Ti‐6Al‐4V with equiaxed microstructure (EM) under different values of tensile mean stress or stress ratio (R) was investigated from high‐cycle fatigue (HCF) to very‐high‐cycle fatigue (VHCF) regimes via ultrasonic axial cycling. The effect of mean stress or R on the fatigue strength of HCF and VHCF was addressed by Goodman, Gerber, and Authors' formula. Three types of crack initiation, namely, surface‐with‐RA (rough area), surface‐without‐RA, and interior‐with‐RA, were classified. The maximum value of stress intensity factor (SIF) at RA boundary for R < 0 keeps constant regardless of R in HCF and VHCF regimes. The SIF range at RA boundary for R > 0 also keeps constant regardless of R in VHCF regime, but this value decreases linearly with the increase of R for surface RA cases. The microstructure observation at RA regions gives a new result of nanograin formation only in the cases of negative stress ratios for the titanium alloy with EM, which is explained by the mechanism of numerous cyclic pressing.
Thermal stress induces persistently altered coral reef fish assemblages
Authors: Robinson James P. W. , Wilson Shaun K. , Jennings Simon , Graham Nicholas A. J. 
Published: June 2019

AbstractEcological communities are reorganizing in response to warming temperatures. For continuous ocean habitats this reorganization is characterized by large‐scale species redistribution, but for tropical discontinuous habitats such as coral reefs, spatial isolation coupled with strong habitat dependence of fish species imply that turnover and local extinctions are more significant mechanisms. In these systems, transient marine heatwaves are causing coral bleaching and profoundly altering habitat structure, yet despite severe bleaching events becoming more frequent and projections indicating annual severe bleaching by the 2050s at most reefs, long‐term effects on the diversity and structure of fish assemblages remain unclear. Using a 23‐year time series spanning a thermal stress event, we describe and model structural changes and recovery trajectories of fish communities after mass bleaching. Communities changed fundamentally, with the new emergent communities dominated by herbivores and persisting for >15 years, a period exceeding realized and projected intervals between thermal stress events on coral reefs. Reefs which shifted to macroalgal states had the lowest species richness and highest compositional dissimilarity, whereas reefs where live coral recovered exceeded prebleaching fish richness, but remained dissimilar to prebleaching compositions. Given realized and projected frequencies of bleaching events, our results show that fish communities historically associated with coral reefs will not re‐establish, requiring substantial adaptation by managers and resource users.
Prognosis of root canal treatment in teeth with preoperative apical periodontitis: a study with cone‐beam computed tomography and digital periapical radiography
Authors: Restrepo‐Restrepo F. A. , Cañas‐Jiménez S. J. , Romero‐Albarracín R. D. , Villa‐Machado P. A. , Pérez‐Cano M. I. , Tobón‐Arroyave S. I. 
Published: June 2019

AbstractAimThis observational cohort study aimed: (i) to determine retrospectively after a 1‐ to 12‐year follow‐up period, the strength and independence of the association of various patient‐, tooth‐ and treatment‐related prognostic variables with the outcome of root canal treatment in patients with pre‐therapeutic apical periodontitis; and (ii) to establish the concordance between those predictors evaluated by both cone‐beam computed tomography (CBCT) and digital periapical radiography (DPR).MethodologyThe study cohort included 125 teeth in 84 individuals. The postoperative clinical signs/symptoms, plus DPR/CBCT‐PAI estimations, were used to determine the healing outcome. For statistical analysis, results were dichotomized into completely healed periapical structures versus persistent disease cases. The association between candidate predictor variables with persistent disease was analysed individually and adjusted for confounders using a multivariate binary logistic regression model.ResultsThe success rate was 53.6%. After logistic regression analysis, mandibular tooth location, periapical lesion size >10 mm, poor quality of the coronal restoration, lack of magnification/illumination, lack of disinfection of gutta‐percha, time elapsed to definitive coronal restoration >1 week and poor density of root canal filling remained as robust predictors of failures. Concordance between DPR and CBCT scores varied from moderate to almost perfect agreement.ConclusionsThe findings of this study suggest that several tooth‐ and treatment‐related predictor variables, including tooth location, periapical radiolucency size, quality of the coronal restoration, magnification/illumination, disinfection of gutta‐percha, time elapsed to definitive coronal restoration, as well as, the density of root canal filling may act strongly and independently for determining the root canal treatment outcome in teeth with pre‐therapeutic apical periodontitis.
Recycling of silicon kerf waste for preparation of porous SiCw/SiC membrane supports by in situ synthesis
Authors: Wu Hua , Ma Beiyue , Ren Xinming , Zhai Yingying , Zhang Yaran , Yang Wengang , Qian Fan , Liu Guoqi , Zhu Qiang 
Published: June 2019

AbstractRecycling has enormous economic benefits and practical significance under the context of gradually increasing solid wastes. In order to recycle and reuse the silicon kerf waste, in this work, porous SiCw/SiC ceramics were successfully prepared by in situ synthesis from silicon kerf waste and fired at 1400‐1500°C for 4 hours. The results showed that these porous ceramics, reinforced by the interlocking whisker, revealed high apparent porosity (48.02%‐51.76%) and cold compressive strength (5.68‐9.54 MPa). Furthermore, the practicable pore size (2.09‐2.53 μm) and decent durability showed the potential of these porous ceramics as membrane supports. This work verified the possibility of the SiC‐based ceramics prepared from the silicon kerf waste.