bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does a social prescribing ‘holistic’ link-worker for older people with complex, multimorbidity improve well-being and frailty and reduce health and social care use and costs? A 12-month before-and-after evaluation
Authors: Elston Julian , Gradinger Felix , Asthana Sheena , Lilley-Woolnough Caroline , Wroe Sue , Harman Helen , Byng Richard 
Published: September 2019

AbstractAim:To evaluate the impact of ‘holistic’ link-workers on service users’ well-being, activation and frailty, and their use of health and social care services and the associated costs.Background:UK policy is encouraging social prescribing (SP) as a means to improve well-being, self-care and reduce demand on the NHS and social services. However, the evidence to support this policy is generally weak and poorly conceptualised, particularly in relation to frail, older people and patient activation. Torbay and South Devon NHS Foundation Trust, an integrated care organisation, commissioned a Well-being Co-ordinator service to support older adults (≥50 years) with complex health needs (≥2 long-term conditions), as part of its service redesign.Methods:A before-and-after study measuring health and social well-being, activation and frailty at 12 weeks and primary, community and secondary care service use and cost at 12 months prior and after intervention.Findings:Most of the 86 participants achieved their goals (85%). On average health and well-being, patient activation and frailty showed a statistically significant improvement in mean score. Mean activity increased for all services (some changes were statistically significant). Forty-four per cent of participants saw a decrease in service use or no change. Thirteen high-cost users (>£5000 change in costs) accounted for 59% of the overall cost increase. This was largely due to significant, rapid escalation in morbidity and frailty. Co-ordinators played a valuable key-worker role, improving the continuity of care, reducing isolation and supporting carers. No entry-level participant characteristic was associated with change in well-being or service use. Larger, better conceptualised, controlled studies are needed to strengthen claims of causality and develop national policy in this area.
Anti-tumoral activity of single and combined regorafenib treatments in preclinical models of liver and gastrointestinal cancers
Authors: Fondevila Flavia , Méndez-Blanco Carolina , Fernández-Palanca Paula , González-Gallego Javier , Mauriz José L. 
Published: September 2019

AbstractRegorafenib is a sorafenib-derived chemotherapy drug belonging to the multikinase inhibitor family. This agent effectively targets a wide range of tyrosine kinases involved in cancer biology, such as those implicated in oncogenesis, angiogenesis, and tumor microenvironment control. The beneficial effects of regorafenib in clinical trials of patients who suffer from advanced hepatocellular carcinoma (HCC), colorectal cancer (CRC) or gastrointestinal stromal tumors (GISTs) refractory to standard treatments led to regorafenib monotherapy approval as a second-line treatment for advanced HCC and as a third-line treatment for advanced CRC and GISTs. Multiple in vitro and in vivo studies have been performed over the last decade to reveal the molecular mechanisms of the favorable actions exerted by regorafenib in patients. Given the hypothetical loss of sensitivity to regorafenib in tumor cells, preclinical research is also searching for novel therapeutic approaches consisting of co-administration of this drug plus other agents as a strategy to improve regorafenib effectiveness. This review summarizes the anti-tumor effects of regorafenib in single or combined treatment in preclinical models of HCC, CRC and GISTs and discusses both the global and molecular effects that account for its anti-cancer properties in the clinical setting.
Selective collection of iron-rich dust particles by natural Trichodesmium colonies
Authors: Kessler Nivi , Armoza-Zvuloni Rachel , Wang Siyuan , Basu Subhajit , Weber Peter K , Stuart Rhona K , Shaked Yeala 
Published: September 2019

Abstract
Dust is an important iron (Fe) source to the ocean, but its utilization by phytoplankton is constrained by rapid sinking and slow dissolution dust-bound iron (dust-Fe). Colonies of the globally important cyanobacterium, Trichodesmium, overcome these constraints by efficient dust capturing and active dust-Fe dissolution. In this study we examined the ability of Trichodesmium colonies to maximize their Fe supply from dust by selectively collecting Fe-rich particles. Testing for selectivity in particle collection, we supplied ~600 individual colonies, collected on multiple days from the Gulf of Aqaba, with natural dust and silica minerals that were either cleaned of or coated with Fe. Using a stereoscope, we counted the number of particles retained by each colony shortly after addition and following 24 h incubation with particles, and documented translocation of particles to the colony core. We observed a strong preference for Fe-rich particles over Fe-free particles in all tested parameters. Moreover, some colonies discarded the Fe-free particles they initially collected. The preferred collection of Fe-rich particles and disposal of Fe-free particles suggest that Trichodesmium can sense Fe and selectively choose Fe-rich dust particles. This ability assists Trichodesmium obtain Fe from dust and facilitate its growth and subsequent contribution to nutrient cycling and productivity in the ocean.
Bayesian ages for pollen records since the last glaciation in North America
Authors: Wang Yue , Goring Simon J. , McGuire Jenny L. 
Published: September 2019

AbstractTerrestrial pollen records are abundant and widely distributed, making them an excellent proxy for past vegetation dynamics. Age-depth models relate pollen samples from sediment cores to a depositional age based on the relationship between sample depth and available chronological controls. Large-scale synthesis of pollen data benefit from consistent treatment of age uncertainties. Generating new age models helps to reduce potential artifacts from legacy age models that used outdated techniques. Traditional age-depth models, often applied for comparative purposes, infer ages by fitting a curve between dated samples. Bacon, based on Bayesian theory, simulates the sediment deposition process, accounting for both variable deposition rates and temporal/spatial autocorrelation of deposition from one sample to another within the core. Bacon provides robust uncertainty estimation across cores with different depositional processes. We use Bacon to estimate pollen sample ages from 554 North American sediment cores. This dataset standardizes age-depth estimations, supporting future large spatial-temporal studies and removes a challenging, computationally-intensive step for scientists interested in questions that integrate across multiple cores.
CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder
Authors: Hoffman Gabriel E. , Bendl Jaroslav , Voloudakis Georgios , Montgomery Kelsey S. , Sloofman Laura , Wang Ying-Chih , Shah Hardik R. , Hauberg Mads E. , Johnson Jessica S. , Girdhar Kiran , Song Lingyun , Fullard John F. , Kramer Robin , Hahn Chang-Gyu , Gur Raquel , Marenco Stefano , Lipska Barbara K. , Lewis David A. , Haroutunian Vahram , Hemby Scott , Sullivan Patrick , Akbarian Schahram , Chess Andrew , Buxbaum Joseph D. , Crawford Greg E. , Domenici Enrico , Devlin Bernie , Sieberts Solveig K. , Peters Mette A. , Roussos Panos 
Published: September 2019

AbstractSchizophrenia and bipolar disorder are serious mental illnesses that affect more than 2% of adults. While large-scale genetics studies have identified genomic regions associated with disease risk, less is known about the molecular mechanisms by which risk alleles with small effects lead to schizophrenia and bipolar disorder. In order to fill this gap between genetics and disease phenotype, we have undertaken a multi-cohort genomics study of postmortem brains from controls, individuals with schizophrenia and bipolar disorder. Here we present a public resource of functional genomic data from the dorsolateral prefrontal cortex (DLPFC; Brodmann areas 9 and 46) of 986 individuals from 4 separate brain banks, including 353 diagnosed with schizophrenia and 120 with bipolar disorder. The genomic data include RNA-seq and SNP genotypes on 980 individuals, and ATAC-seq on 269 individuals, of which 264 are a subset of individuals with RNA-seq. We have performed extensive preprocessing and quality control on these data so that the research community can take advantage of this public resource available on the Synapse platform at http://CommonMind.org.
A dataset of cetacean occurrences in the Eastern North Atlantic
Authors: Correia Ana M. , Gandra Miguel , Liberal Marcos , Valente Raul , Gil Ágatha , Rosso Massimiliano , Pierce Graham J. , Sousa-Pinto Isabel 
Published: September 2019

AbstractThe CETUS project is a cetacean monitoring program that takes advantage of cargo ships to undertake survey routes between Continental Portugal, Macaronesian archipelagos and West Africa. From 2012 to 2017, over 50 volunteers participated in the program, actively surveying more than 124.000 km, mostly beyond national jurisdictions in the high seas, for which little or no previous data existed. In total, the collection comprises 3058 georeferenced transect lines and 8913 positions, which are associated with 2833 cetacean sightings, 362 occurrences of other pelagic megafauna, 5260 estimates of marine traffic and 8887 weather observations. This dataset may provide new insights into the distribution of marine mammals in the Eastern North Atlantic and was published following the OBIS-ENV-DATA format (with the most recent biodiversity data standards at the time of writing). Consequently, it may serve as a model for similar visual line transect data collections yet to be published.
PalmTraits 1.0, a species-level functional trait database of palms worldwide
Authors: Kissling W. Daniel , Balslev Henrik , Baker William J. , Dransfield John , Göldel Bastian , Lim Jun Ying , Onstein Renske E. , Svenning Jens-Christian 
Published: September 2019

AbstractPlant traits are critical to plant form and function —including growth, survival and reproduction— and therefore shape fundamental aspects of population and ecosystem dynamics as well as ecosystem services. Here, we present a global species-level compilation of key functional traits for palms (Arecaceae), a plant family with keystone importance in tropical and subtropical ecosystems. We derived measurements of essential functional traits for all (>2500) palm species from key sources such as monographs, books, other scientific publications, as well as herbarium collections. This includes traits related to growth form, stems, armature, leaves and fruits. Although many species are still lacking trait information, the standardized and global coverage of the data set will be important for supporting future studies in tropical ecology, rainforest evolution, paleoecology, biogeography, macroecology, macroevolution, global change biology and conservation. Potential uses are comparative eco-evolutionary studies, ecological research on community dynamics, plant-animal interactions and ecosystem functioning, studies on plant-based ecosystem services, as well as conservation science concerned with the loss and restoration of functional diversity in a changing world.
Diverse roles of non-muscle myosin II contractility in 3D cell migration
Authors: Agarwal Priti , Zaidel-Bar Ronen 
Published: September 2019

Abstract
All is flux, nothing stays still. Heraclitus of Ephesus’ characterization of the universe holds true for cells within animals and for proteins within cells. In this review, we examine the dynamics of actin and non-muscle myosin II within cells, and how their dynamics power the movement of cells within tissues. The 3D environment that migrating cells encounter along their path also changes over time, and cells can adopt various mechanisms of motility, depending on the topography, mechanics and chemical composition of their surroundings. We describe the differential spatio-temporal regulation of actin and myosin II-mediated contractility in mesenchymal, lobopodial, amoeboid, and swimming modes of cell migration. After briefly reviewing the biochemistry of myosin II, we discuss the role actomyosin contractility plays in the switch between modes of 3D migration that cells use to adapt to changing environments.
Current State of Care for Pediatric ACL Ruptures in the Netherlands: A Survey
Authors: Dietvorst Martijn , Reijman Max , van Zutven Rein , van den Bekerom Michel P. J. , Meuffels Duncan E. , Somford Matthijs P. , Janssen Rob P. A. 
Published: September 2019

AbstractThe management of anterior cruciate ligament (ACL) injuries in the skeletally immature patient is an area of controversy. The purpose of this survey is to inventory the current state of care for pediatric ACL injuries in the Netherlands. This survey was conveyed by e-mail among all members of the Dutch Arthroscopy Society (Nederlandse Vereniging van Arthroscopie [NVA]) and promoted on the Web site of the NVA. It was developed by the scientific committee of the NVA by a consensus meeting discussing relevant topics in pediatric ACL injuries. All members of the NVA received the survey (n = 540). A total of 158 (29%) members responded to the survey, of which 143 were completed. A total of 126 responses were analyzed after exclusion. The main finding of this survey is that 78% of the respondents tend to treat children with open physes nonoperatively, while 65% tend to treat children with closed physes operatively. The most frequently performed procedure is the transphyseal reconstruction. Many considerations were involved in choosing operative treatment. The postoperative follow-up period varies from less than 1 year (24%) until fully grown (27%). In conclusion, this survey shows that the current state of care for pediatric ACL injuries is variable and a matter of debate in the Netherlands. Although the response rate seems low, this survey provides an overview of the opinions of specialized orthopaedic surgeons in the Netherlands. The results of this survey led to the development of the national registry for pediatric ACL in the Netherlands. The level of evidence for this study is V.
The role of lexical stress in spoken English word recognition by listeners of English and Taiwan Mandarin
Authors: Ou Shu-chen 
Published: September 2019

Abstract
Two perceptual experiments investigated how the suprasegmental information of monosyllables is perceived and exploited in spoken English word recognition by listeners of English and Taiwan Mandarin (TM). Using an auditory lexical decision task in which correctly stressed English words and mis-stressed nonwords (e.g. camPAIGN vs. *CAMpaign) were presented for lexical decisions, Experiment I demonstrated that TM listeners could perceive the differences between stressed and unstressed syllables with native-like accuracy and rapidity. To examine how the perceived suprasegmental contrast would constrain English lexical access, Experiment II was conducted. It used a cross-modal fragment priming task in which a lexical decision had to be made for a visually presented English word or nonword following an auditory prime, which was a spoken word-initial syllable. The results showed that English and TM listeners recognized the displayed word (e.g. campus) faster both after a stress-matching (e.g. CAM-) prime and a stress-mismatching (e.g. cam-) prime than after a control prime (e.g. MOUN-, with mismatching segments). This indicates that suprasegmental information does not inhibit a segmentally matching but suprasegmentally mismatching word candidate for both the two groups, although TM is a language where lexical prosody is expressed syllabically and its listeners tend to interpret lexical stress tonally. Yet, the two groups’ responses were slower after the stressed primes than after the unstressed ones, presumably because the former generally had more possible continuations than the latter do. It is therefore concluded that when recognizing spoken English words, both the native and non-native (TM-speaking) listeners can exploit the suprasegmental cues of monosyllables, which, however, are not so effective that they will outweigh the segmental cues.
Brevinin-GR23 from frog Hylarana guentheri with antimicrobial and antibiofilm activities against Staphylococcus aureus
Authors: Zhong Hengren , Xie Zhipeng , Zhang Shuxia , Wei Hanqi , Song Yanting , Zhang Yingxia , Wang Manchuriga 
Published: September 2019

ABSTRACT
Brevinin-GR23 (B-GR23) was a brevinin-2 like antimicrobial peptide, which had antimicrobial activity against Staphylococcus aureus with minimum inhibitory concentration (MIC) of 16 μM. B-GR23 increased the bacterial membrane permeation, leading to the damage of membrane integrity and the leakage of genomic DNA, then causing the cell death. The peptide nearly inhibited all plantonic bacteria to start the initial attachment of biofilm at the concentration of 1 × MIC. Whereas the disruption rates on immature and mature biofilm decreased from 60% to 20%. B-GR23 reduced the production of extracellular polysaccharides (EPS) in the planktonic growth of S. aureus, which is a crucial structure of biofilm formation. B-GR23 with the concentration of ½ × MIC inhibited 50% water-soluble EPS, and 48% water-insoluble EPS, which contributed to the antibiofilm activity. B-GR23 had no significant toxicity to human blood cells under-tested concentration (200 μM), making it a potential template for designing antimicrobial peptides.
Simulation of the ion cyclotron range of frequencies slow wave and the lower hybrid resonance in 3D in RAPLICASOL
Authors: Usoltceva M , Ochoukov R , Tierens W , Kostic A , Crombé K , Heuraux S , Noterdaeme J-M 
Published: September 2019

Abstract
Ion cyclotron range of frequencies (ICRF) wave propagation is calculated theoretically for tokamak conditions and for linear magnetized plasma device IShTAR which is dedicated to the RF sheath studies. Only the slow wave (SW) mode of ICRF waves can propagate and be studied in IShTAR. Therefore it is possible to decouple the role of the different ICRF modes in the RF sheath effects. Numerical simulations of the ICRF SW are done in COMSOL in the framework of the existing cold plasma modelling package RAPLICASOL and the SW is for the first time modelled in 3D. To date, RAPLICASOL existed as a 3D wave coupling modelling approach which targets the fast wave (FW). Plasma is implemented as a material with manually assigned physical properties and a perfectly matched layer (PML) is used to absorb the wave energy. Here it is demonstarted how to adjust the RAPLICASOL PML for models with propagating SW. Field structures in the resonance cone shape obtained for the SW differ significantly from the FW and exhibit strong dependence on the density profile in the close proximity of the antenna. The lower-hybrid (LH) resonance is a constant issue in the attempts to model the SW. In this work an approach to obtain correct numerical solutions in the LH resonance presence is demonstrated. Results of this work can be used to improve the complex tokamak ICRF simulations, where so far the SW propagation on the edge has been avoided.
Air tightness of hBN encapsulation and its impact on Raman spectroscopy of van der Waals materials
Authors: Holler Johannes , Bauriedl Lorenz , Korn Tobias , Seitz Andrea , Özyigit Furkan , Eichinger Michaela , Schüller Christian , Watanabe Kenji , Taniguchi Takashi , Strunk Christoph , Paradiso Nicola 
Published: September 2019

Abstract
Raman spectroscopy is a precious tool for the characterization of van der Waals materials, e.g. for the determination of the layer number in thin exfoliated flakes. For sensitive materials, however, this method can be dramatically invasive. In particular, the light intensity required to obtain a significant Raman signal is sufficient to immediately photo-oxidize few-layer thick metallic van der Waals materials. In this work we investigated the impact of the environment on Raman characterization of thin NbSe2 crystals. We show that in ambient conditions the flake is locally oxidized even for very low illumination intensity. Based on this extreme sensitivity to the presence of light and oxygen, we could study the air-tightness of the hBN encapsulation method, the most common passivation method for a wide range of 2D material-based devices. We find that only fully encapsulated devices are reliably air-tight. On the contrary, a simple hBN cover from the top does not prevent a slow diffusion of oxygen between the SiO2 surface and the flake itself.
Community-acquired acute bacterial meningitis in adults: a clinical update
Authors: Ellis Jayne , Luintel Akish , Chandna Arjun , Heyderman Robert S 
Published: September 2019

AbstractBackgroundAcute bacterial meningitis (ABM) in adults is associated with a mortality that may exceed 30%. Immunization programs have reduced the global burden; in the UK, declining incidence but persistently high mortality and morbidity mean that clinicians must remain vigilant.Sources of dataA systematic electronic literature search of PubMed was performed to identify all ABM literature published within the past 5 years.Areas of agreement and controversyClinical features cannot reliably distinguish between ABM and other important infectious and non-infectious aetiologies. Prompt investigation and empirical treatment are imperative. Lumbar puncture (LP) and cerebrospinal fluid microscopy, biochemistry and culture remain the mainstay of diagnosis, but molecular techniques are increasingly useful. The 2016 UK joint specialist societies’ guideline provides expert recommendations for the management of ABM, yet published data suggest clinical care delivered in the UK is frequently not adherent. Anxiety regarding risk of cerebral herniation following LP, unnecessary neuroimaging, underutilization of molecular diagnostics and suboptimal uptake of adjunctive corticosteroids compromise management.Growing pointsThere is increasing recognition that current antibiotic regimens and adjunctive therapies alone are insufficient to reduce the mortality and morbidity associated with ABM.Areas timely for developing researchResearch should be focused on optimization of vaccines (e.g. pneumococcal conjugate vaccines with extended serotype coverage), targeting groups at risk for disease and reservoirs for transmission; improving adherence to management guidelines; development of new faster, more accurate diagnostic platforms (e.g. novel point-of-care molecular diagnostics); and development of new adjunctive therapies (aimed at the host-inflammatory response and bacterial virulence factors).
ProtMiscuity: a database of promiscuous proteins
Authors: Velez Rueda Ana Julia , Palopoli Nicolas , Zacarías Matías , Sommese Leandro Matías , Parisi Gustavo 
Published: September 2019

Abstract
Promiscuous behaviour in proteins and enzymes remains a challenging feature to understand the structure–function relationship. Here we present ProtMiscuity, a manually curated online database of proteins showing catalytic promiscuity. ProtMiscuity contains information about canonical and promiscuous activities comprising 88 different reactions in 57 proteins from 40 different organisms. It can be searched or browsed by protein names, organisms and descriptions of canonical and promiscuous reactions. Entries provide information on reaction substrates, products and kinetic parameters, mapping of active sites to sequence and structure and links to external resources with biological and functional annotations. ProtMiscuity could assist in studying the underlying mechanisms of promiscuous reactions by offering a unique and curated collection of experimentally derived data that is otherwise hard to find, retrieve and validate from literature.