bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exergetic, economic, and environmental analyses of combined cooling and power plants with parabolic solar collector
Authors: Javadi Mohammad Amin , Ahmadi Mohammad Hossein , Khalaji Mehdi 
Published: July 2019

AbstractDue to the necessity of achieving the energy systems with improved efficiency, combined power plants are developing in recent decades. Moreover, employing renewable energy sources in the power generation and heating/cooling purposes is an attractive idea to obtain more environmentally benign energy systems. In the current study, a combined cooling and power (CCP) plant is analyzed based on exergy and economic concepts. Afterward, by adding lithium‐bromide refrigeration cycle and parabolic solar collectors, the plant is investigated. The exergy efficiency, carbon dioxide emission, and cost of generated electricity are evaluated on the basis of SPECO model. The results of the study show that thermal and exergy efficiencies of the CCP plant with the solar collector depend on various parameters and can be affected significantly. The efficiency of the plant after applying lithium‐bromide refrigeration cycle and the solar collector increased from 50.33 to 51.73%, while the exergy efficiency enhanced from 47.48 to 48.22%. In addition, it was concluded that adding the collector and absorption chiller leads to 1.5% reduction in environmental pollutants.
Geomorphic and hydrological controls on groundwater dolocrete formation in the semi‐arid Hamersley Basin, northwest Australia
Authors: Mather Caroline C. , Nash David J. , Dogramaci Shawan , Grierson Pauline F. , Skrzypek Grzegorz 
Published: July 2019

AbstractGroundwater dolocretes may exert an important geomorphic control on landscape evolution within sub‐humid to arid regions. However, the geomorphic and hydrogeological settings of dolocrete remain poorly described. The hydrochemical conditions of dolomite precipitation in groundwater environments are also not well known. Classic models of dolocrete formation explain dolomite precipitation from highly evolved groundwaters at the terminus of major drainage but do not explain dolocrete distributed in regionally elevated landscapes, upgradient of major drainage. This study investigated the mineralogy, micromorphology and stable carbon and oxygen isotope compositions of three dolocrete profiles within a regionally elevated sub‐basin of the Hamersley Ranges in the Pilbara region of northwest Australia. We sought to establish the environmental and hydrochemical conditions and present a model for dolocrete formation. We found that dolocrete formed within zones of emerging groundwater under saline‐evaporitic conditions within internally draining sub‐basins, most likely during the Late Miocene and Pliocene. Saline‐evaporitic conditions were indicated by: (i) the mineralogy, dominated by dolomite, palygorskite and smectite; (ii) desiccation features and the presence of phreatic and vadose cements, indicative of a shallow fluctuating water table, and; (iii) dolomite δ18O values (median = –5.88 ‰). Dolomite precipitation was promoted by evaporation and carbon dioxide degassing from shallow magnesium (Mg)‐rich groundwater. These factors appear to have been the major drivers of dolocrete development without a requirement for significant down‐dip hydrochemical modification. Primary dolomite precipitation was possible due to the presence of microbial extracellular polymeric substances (EPS). EPS provided negatively charged nucleation sites, which bound Mg2+, overcoming kinetic effects. High microbial activity within groundwater systems suggest these processes may be important for dolocrete formation worldwide and that groundwater dolocretes may be more pervasive in landscapes than currently recognized. © 2019 John Wiley & Sons, Ltd. © 2019 John Wiley & Sons, Ltd.
Options pricing and short‐selling in the underlying: Evidence from India
Authors: Dixit Alok ,   Vipul , Singh Shivam 
Published: July 2019

AbstractThis study provides new insights into certain recent developments in derivatives trading in India. Specifically, it examines the implications of introduction of short‐selling for pricing efficiency of the Nifty 50 index derivative contracts of National Stock Exchange of India. The empirical results suggest that the introduction of short‐selling, supported by a well‐functioning security lending and borrowing market, has significantly reduced the overpricing of Nifty 50 index put options. Moreover, the introduction of this short‐selling mechanism has lessened the underpricing of Nifty 50 index futures.
A dimension‐invariant cascade model for VIX futures
Authors: Wang Zhiguang , Dupoyet Brice 
Published: July 2019

AbstractWe propose a new stochastic volatility model by allowing for a cascading structure of volatility components. The model, under a minor assumption, allows us to add as many components as desired with no additional parameters, effectively defeating the curse of dimensionality often encountered in traditional models. We derive a semi‐closed‐form solution to the VIX futures price, and find that our six‐factor model with only six parameters can closely fit spot VIX and VIX futures prices from 2004 to 2015 and produce out‐of‐sample pricing errors of magnitudes similar to those of in‐sample errors.
Role of a Contactin multi‐molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS
Authors: Dubessy Anne‐Laure , Mazuir Elisa , Rappeneau Quentin , Ou Sokounthie , Abi Ghanem Charly , Piquand Kevin , Aigrot Marie‐Stéphane , Thétiot Melina , Desmazières Anne , Chan Eric , Fitzgibbon Matt , Fleming Mark , Krauss Raul , Zalc Bernard , Ranscht Barbara , Lubetzki Catherine , Sol‐Foulon Nathalie 
Published: July 2019

AbstractThe fast and reliable propagation of action potentials along myelinated fibers relies on the clustering of voltage‐gated sodium channels at nodes of Ranvier. Axo‐glial communication is required for assembly of nodal proteins in the central nervous system, yet the underlying mechanisms remain poorly understood. Oligodendrocytes are known to support node of Ranvier assembly through paranodal junction formation. In addition, the formation of early nodal protein clusters (or prenodes) along axons prior to myelination has been reported, and can be induced by oligodendrocyte conditioned medium (OCM). Our recent work on cultured hippocampal neurons showed that OCM‐induced prenodes are associated with an increased conduction velocity (Freeman et al., 2015). We here unravel the nature of the oligodendroglial secreted factors. Mass spectrometry analysis of OCM identified several candidate proteins (i.e., Contactin‐1, ChL1, NrCAM, Noelin2, RPTP/Phosphacan, and Tenascin‐R). We show that Contactin‐1 combined with RPTP/Phosphacan or Tenascin‐R induces clusters of nodal proteins along hippocampal GABAergic axons. Furthermore, Contactin‐1‐immunodepleted OCM or OCM from Cntn1‐null mice display significantly reduced clustering activity, that is restored by addition of soluble Contactin‐1. Altogether, our results identify Contactin‐1 secreted by oligodendrocytes as a novel factor that may influence early steps of nodal sodium channel cluster formation along specific axon populations.
Characterization of a long noncoding RNA Pcdh17it as a novel marker for immature premyelinating oligodendrocytes
Authors: Kasuga Yusuke , Fudge Alexander D. , Zhang Yumeng , Li Huiliang 
Published: July 2019

AbstractOligodendrocyte precursors (OPs) proliferate and differentiate into oligodendrocytes (OLs) during postnatal development and into adulthood in the central nervous system (CNS). Following the initiation of differentiation, OPs give rise to immature, premyelinating OLs, which undergo further differentiation and mature into myelin‐forming OLs. We identified an immature OL‐specific long noncoding RNA, named Pcdh17it. Through co‐localization analysis and morphological characterization of OLs, we found that Pcdh17it is a specific marker for newly born immature OLs in the developing and adult forebrain of mice, and we used this new marker to analyze OL generation over the lifespan of mice. Pcdh17it is an effective tool for monitoring newly born OLs in adult brain, allowing detailed study of the dynamics of OP differentiation into OLs in the normal and pathological CNS.
The Mutational Features of Aristolochic Acid–Induced Mouse and Human Liver Cancers
Authors: Lu Zhao‐Ning , Luo Qing , Zhao Li‐Nan , Shi Yi , Wang Na , Wang Lan , Han Ze‐Guang 
Published: July 2019

Background and Aims
Aristolochic acid (AA) exposure has been statistically associated with human liver cancers. However, direct evidence of AA exposure–induced liver cancer is absent. This study aims to establish a direct causal relationship between AA exposure and liver cancers based on a mouse model and then explores the AA‐mediated genomic alterations that could be implicated in human cancers with AA‐associated mutational signature.

Approach and Results
We subjected mice, including phosphatase and tensin homolog (Pten)‐deficient ones, to aristolochic acid I (AAI) alone or a combination of AAI and CCl4. Significantly, AAI exposure induced mouse liver cancers, including hepatocellular carcinoma (HCC) and combined HCC and intrahepatic cholangiocarcinoma, in a dose‐dependent manner. Moreover, AAI exposure also enhanced tumorigenesis in these CCl4‐treated or Pten‐deficient mice. AAI led to DNA damage and AAI‐DNA adduct that could initiate liver cancers through characteristic adenine‐to‐thymine transversions, as indicated by comprehensive genomic analysis, which revealed recurrent mutations in Harvey rat sarcoma virus oncogene. Interestingly, an AA‐associated mutational signature was mainly implicated in human liver cancers, especially from China. Moreover, we detected the AAI‐DNA adduct in 25.8% (16/62) of paratumor liver tissues from randomly selected Chinese patients with HCC. Furthermore, based on phylogenetic analysis, the characteristic mutations were found in the initiating malignant clones in the AA‐implicated mouse and human liver cancers where the mutations of tumor protein p53 and Janus kinase 1 were prone to be significantly enriched in the AA‐affected human tumors.

Conclusions
This study provides evidence for AA‐induced liver cancer with the featured mutational processes during malignant clonal evolution, laying a solid foundation for the prevention and diagnosis of AA‐associated human cancers, especially liver cancers.
Peribiliary Gland Niche Participates in Biliary Tree Regeneration in Mouse and in Human Primary Sclerosing Cholangitis
Authors: Carpino Guido , Nevi Lorenzo , Overi Diletta , Cardinale Vincenzo , Lu Wei‐Yu , Di Matteo Sabina , Safarikia Samira , Berloco Pasquale Bartolomeo , Venere Rosanna , Onori Paolo , Franchitto Antonio , Forbes Stuart J. , Alvaro Domenico , Gaudio Eugenio 
Published: July 2019

Background and Aims
Mechanisms underlying the repair of extrahepatic biliary tree (EHBT) after injury have been scarcely explored. The aims of this study were to evaluate, by using a lineage tracing approach, the contribution of peribiliary gland (PBG) niche in the regeneration of EHBT after damage and to evaluate, in vivo and in vitro, the signaling pathways involved.

Approach and Results
Bile duct injury was induced by the administration of 3,5‐diethoxycarbonyl‐1,4‐dihydrocollidine (DDC) diet for 14 days to Krt19CreTdTomatoLSL mice. Human biliary tree stem/progenitor cells (BTSC) within PBGs were isolated from EHBT obtained from liver donors. Hepatic duct samples (n = 10) were obtained from patients affected by primary sclerosing cholangitis (PSC). Samples were analyzed by histology, immunohistochemistry, western blotting, and polymerase chain reaction. DDC administration causes hyperplasia of PBGs and periductal fibrosis in EHBT. A PBG cell population (Cytokeratin19‐/SOX9+) is involved in the renewal of surface epithelium in injured EHBT. The Wnt signaling pathway triggers human BTSC proliferation in vitro and influences PBG hyperplasia in vivo in the DDC‐mediated mouse biliary injury model. The Notch signaling pathway activation induces BTSC differentiation in vitro toward mature cholangiocytes and is associated with PBG activation in the DDC model. In human PSC, inflammatory and stromal cells trigger PBG activation through the up‐regulation of the Wnt and Notch signaling pathways.

Conclusions
We demonstrated the involvement of PBG cells in regenerating the injured biliary epithelium and identified the signaling pathways driving BTSC activation. These results could have relevant implications on the pathophysiology and treatment of cholangiopathies.
LncRNA LINP1 regulates acute myeloid leukemia progression via HNF4α/AMPK/WNT5A signaling pathway
Authors: Shi Jie , Dai Rongqin , Chen Yuqing , Guo Honggang , Han Yinyin , Zhang Yin 
Published: July 2019

AbstractLncRNAs play critical roles in various pathophysiological and biological processes, such as protein translation, RNA splicing, and epigenetic modification. Indeed, abundant evidences demonstrated that lncRNA act as competing endogenous RNAs (ceRNAs) to participate in tumorigenesis. However, little is known about the underlying function of lncRNA in nonhomologous end joining (NHEJ) pathway 1 (LINP1) in pediatric and adolescent acute myeloid leukemia (AML). The expression of LINP1 was examined in AML patient samples by qRT‐PCR. Cell proliferation was examined by CCK‐8 and Edu assays. β‐Galactosidase senescence assay, mGlucose uptake assay, lactate production assay, and Gene Ontology (GO) analysis were performed for functional analysis. We found that LINP1 was significantly overexpressed in AML patients at diagnosis, whereas downregulated after complete remission (CR). Furthermore, knockdown of LINP1 expression remarkably suppressed glucose uptake and AML cell maintenance. Mechanistically, LINP1 was found to inhibit the glucose metabolism by suppressing the expression of HNF4a. Both LINP1 and HNF4a knockdown reduced the expression levels of AMPK phosphorylation and WNT5A, indicating for the first time that LINP1 strengthened the HNF4a‐AMPK/WNT5A signaling pathway involved in cell glucose metabolism modulation and AML cell survival. Taken together, our results indicated that LINP1 promotes the malignant phenotype of AML cells and stimulates glucose metabolism, which can be regarded as a potential prognostic marker and therapeutic target for AML.
Minimal residual disease (MRD) in non‐Hodgkin lymphomas: Interlaboratory reproducibility on marrow samples with very low levels of disease within the FIL (Fondazione Italiana Linfomi) MRD Network
Authors: Della Starza Irene , Cavalli Marzia , De Novi Lucia Anna , Genuardi Elisa , Mantoan Barbara , Drandi Daniela , Barbero Daniela , Ciabatti Elena , Grassi Susanna , Gazzola Anna , Mannu Claudia , Agostinelli Claudio , Piccaluga Pier Paolo , Bomben Riccardo , Degan Massimo , Gattei Valter , Guarini Anna , Foà Robin , Galimberti Sara , Ladetto Marco , Ferrero Simone , Del Giudice Ilaria ,   on behalf of the Fondazione Italiana Linfomi (FIL) MRD Network
Published: July 2019

AbstractIn 2009, the four laboratories of the Fondazione Italiana Linfomi (FIL) minimal residual disease (MRD) Network started a collaborative effort to harmonize and standardize their methodologies at the national level, performing quality control (QC) rounds for follicular lymphoma (FL) and mantle cell lymphoma (MCL) MRD assessment. In 16 QC rounds between 2010 and 2017, the four laboratories received 208 bone marrow (BM) samples (126 FL; 82 MCL); 187 were analyzed, according to the EuroMRD Consortium guidelines, by both nested (NEST) polymerase chain reaction (PCR) and real‐time quantitative (RQ) PCR for BCL2/IGH MBR or IGHV rearrangements. Here, we aimed at analyzing the samples that challenged the interlaboratory reproducibility and data interpretation. Overall, 156/187 BM samples (83%) were concordantly classified as NEST+/RQ+ or NEST−/RQ− by all the four laboratories. The remaining 31 samples (17%) resulted alternatively positive and negative in the interlaboratory evaluations, independently of the method and the type of rearrangement, and were defined “borderline” (brd) samples: 12 proved NEST brd/RQ brd, 7 NEST−/RQ brd, 10 NEST brd/RQ positive not quantifiable (PNQ), and 2 NEST brd/RQ−. Results did not change even increasing the number of replicates/sample. In 6/31 brd samples, droplet digital PCR (ddPCR) was tested and showed no interlaboratory discordance. Despite the high interlaboratory reproducibility in the MRD analysis obtained and maintained by the QC round strategy, samples with the lowest MRD levels can still represent a challenge: 17% (31/187) of our samples showed discordant results in interlaboratory assessments, with 6.4% (12/187) remained brd even applying the two methods. Thus, although representing a minority, brd samples are still problematic, especially when a clinically oriented interpretation of MRD results is required. Alternative, novel methods such as ddPCR and next‐generation sequencing have the potential to overcome the current limitations.
Recent research progresses in ether‐ and ester‐based electrolytes for sodium‐ion batteries
Authors: Lin Zeheng , Xia Qingbing , Wang Wanlin , Li Weishan , Chou Shulei 
Published: July 2019

AbstractOwing to the natural abundance and low cost of sodium resources, sodium‐ion batteries (SIBs) have drawn considerable attention for state‐of‐the‐art power storage devices over the last few years. To enable advanced SIBs with a brighter future, great effort has been made, not only through optimizing the electrode materials, but also with rationally designing various electrolyte systems. Among the available electrolyte systems, organic electrolytes, especially those based on esters as well as ethers, are the most promising ones for practical application in the foreseeable future, due to their numerous inherent advantages. This review is concerned with the recent research progresses on organic electrolytes for SIBs, focusing on ether‐based and ester‐based ones.
Detecting nucleic acid fragments in serum using a magnetically modulated sandwich assay
Authors: Margulis Michael , Ashri Saar , Cohen Meir , Danielli Amos 
Published: July 2019

AbstractWe present a novel assay for rapid and highly sensitive detection of specific nucleic acid fragments in human serum. In a magnetic modulation biosensing (MMB) system, magnetic beads and fluorescently labeled probes are attached to the target analyte and form a “sandwich” complex. An alternating external magnetic field gradient condenses the magnetic beads (and hence the target molecules with the fluorescently labeled probes) to the detection volume and sets them in a periodic motion, in and out of a laser beam. A synchronous detection enables the removal of background signal from the oscillating target signal without complicated sample preparation. The high sensitivity of the MMB system, combined with the specificity of a sandwich hybridization assay, enables detection of DNA fragments without enzymatic signal amplification. Here, we demonstrate the sensitivity of the assay by directly detecting the EML4‐ALK oncogenic translocation sequence spiked in human serum. The calculated limit of detection is 1.4 pM, which is approximately 150 times better than a conventional plate reader. In general, the MMB‐assisted SHA can be implemented in many other applications for which enzymatic amplification, such as PCR, is not applicable and where rapid detection of specific nucleic acid targets is required.
Physiological model using diffuse reflectance spectroscopy for nonmelanoma skin cancer diagnosis
Authors: Zhang Yao , Moy Austin J. , Feng Xu , Nguyen Hieu T. M. , Reichenberg Jason S. , Markey Mia K. , Tunnell James W. 
Published: July 2019

AbstractDiffuse reflectance spectroscopy (DRS) is a noninvasive, fast, and low‐cost technology with potential to assist cancer diagnosis. The goal of this study was to test the capability of our physiological model, a computational Monte Carlo lookup table inverse model, for nonmelanoma skin cancer diagnosis. We applied this model on a clinical DRS dataset to extract scattering parameters, blood volume fraction, oxygen saturation and vessel radius. We found that the model was able to capture physiological information relevant to skin cancer. We used the extracted parameters to classify (basal cell carcinoma [BCC], squamous cell carcinoma [SCC]) vs actinic keratosis (AK) and (BCC, SCC, AK) vs normal. The area under the receiver operating characteristic curve achieved by the classifiers trained on the parameters extracted using the physiological model is comparable to that of classifiers trained on features extracted via Principal Component Analysis. Our findings suggest that DRS can reveal physiologic characteristics of skin and this physiologic model offers greater flexibility for diagnosing skin cancer than a pure statistical analysis. Physiological parameters extracted from diffuse reflectance spectra data for nonmelanoma skin cancer diagnosis.
Aligned fibrous decellularized cell derived matrices for mesenchymal stem cell amplification
Authors: Ventre Maurizio , Coppola Valerio , Natale Carlo F. , Netti Paolo A. 
Published: July 2019

AbstractBiochemical and biophysical stimuli of stem cell niches finely regulate the self‐renewal/differentiation equilibrium. Replicating this in vitro is technically challenging, making the control of stem cell functions difficult. Cell derived matrices capture certain aspect of niches that influence fate decisions. Here, aligned fibrous matrices synthesized by MC3T3 cells were produced and the role of matrix orientation and stiffness on the maintenance of stem cell characteristics and adipo‐ or osteo‐genic differentiation of murine mesenchymal stem cells (mMSCs) was investigated. Decellularized matrices promoted mMSC proliferation. Fibrillar alignment and matrix stiffness work in concert in defining cell fate. Soft matrices preserve stemness, whereas stiff ones, in presence of biochemical supplements, promptly induce differentiation. Matrix alignment impacts the homogeneity of the cell population, that is, soft aligned matrices ameliorate the spontaneous adipogenic differentiation, whereas stiff aligned matrices reduce cross‐differentiation. We infer that mechanical signaling is a dominant factor in mMSC fate decision and the matrix alignment contributes to produce a more homogeneous environment, which results in a uniform response of cells to biophysical environment. Matrix thus produced can be obtained in vitro in a facile and consistent manner and can be used for homogeneous stem cell amplification or for mechanotransduction‐related studies.