bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Treatment Patterns and Survival Outcomes in Elderly Pancreatic Cancer Patients: A Surveillance, Epidemiology, and End Results-Medicare Analysis
Authors: Shaib Walid L. , Jones Jeb S. , Goodman Michael , Sarmiento Juan M. , Maithel Shishir K. , Cardona Kenneth , Kane Sujata , Wu Christina , Alese Olatunji B. , El-Rayes Bassel F. 
Published: February 2018

Abstract

Background
Management of pancreatic cancer (PC) in elderly patients is unknown; clinical trials exclude patients with comorbidities and those of extreme age. This study evaluated treatment patterns and survival outcomes in elderly PC patients using linked Surveillance, Epidemiology, and End Results (SEER) and Medicare data.

Materials and Methods
Histology codes 8140, 8500, 8010, 8560, 8490, 8000, 8260, 8255, 8261, 8263, 8020, 8050, 8141, 8144, 8210, 8211, or 8262 in Medicare Parts A and B were identified. Data regarding demographic, characteristics, treatments, and vital status between 1998 and 2009 were collected from the SEER. Determinants of treatment receipt and overall survival were examined using logistic regression and Cox proportional hazards models, respectively.

Results
A total of 5,975 patients met inclusion. The majority of patients were non-Hispanic whites (85%) and female (55%). Most cases presented with locoregional stage disease (74%); 41% received only chemotherapy, 30% chemotherapy and surgery, 10% surgery alone, 3% radiation, and 16% no cancer-directed therapy. Patients with more advanced cancer, older age, and those residing in areas of poverty were more likely to receive no treatment. Among patients 66–74 years of age with locoregional disease, surgery alone (hazard ratio [HR] = 0.54; 95% confidence interval [CI]: 0.39–0.74) and surgery in combination with chemotherapy (HR = 0.69; 95% CI: 0.53–0.91) showed survival benefit as compared with the no treatment group. Among patients ≥75 years of age with locoregional disease, surgery alone (HR = 2.04; 95% CI: 0.87–4.8) or in combination with chemotherapy (HR = 1.59; 95% CI: 0.87–2.91) was not associated with better survival.

Conclusion
Treatment modality and survival differs by age and stage. Low socioeconomic status appears to be a major barrier to the receipt of PC therapy among Medicare patients.

Implications for Practice
Elderly patients with cancer are under-represented on clinical trials and usually have comorbid illnesses. The management of elderly patients with pancreatic cancer is unknown, with many retrospective experiences but low sample sizes. Using Surveillance, Epidemiology, and End Results-Medicare linked data to analyze treatment patterns and survival of elderly patients with pancreatic cancer on a larger population scale, this study highlights treatment patterns and their effect on survival and proposes possible obstacles to access of care in elderly patients with pancreatic cancer other than Medicare coverage.
Síntesis, análisis estructural, estabilidad química, estudio magnético y efecto percolativo eléctrico del compositor GdBa2Cu3O7−δ /Sr2GdSbO6
Authors: Montana Quintero Nilzon 
Published: February 2018

En este trabajo se reporta la síntesis de los materiales Sr2GdSbO6 (SGSO) y GdBa2Cu3O7−δ (GBCO),por el método de reacción en estado sólido y de compósitos GdBa2Cu3O7−δ /Sr2GdSbO6 (GBCO/SGSO)en diferentes proporciones volumétricas. La caracterización estructural de los compuestos sintetizadosse realizó por medio de difracción de rayos X, usando el método de re namiento Rietveld, realizando un análisis cuantitativo de fases en volumen. Los resultados obtenidos permiten con rmar que los dos materiales (GBCO/SGSO) son estables químicamente, coexistiendo en un mismo volumen a 900 C. También se encontró, mediante medidas de magnetización, que el GBCO contenido en cada uno de los diferentescompósitos, conservó sus propiedades superconductoras, ya que se obtuvo la transición al estado supercon- ductor por debajo de una temperatura de 90 K. La caracterización morfológica se realizó mediante medidas de microscopia electrónica de barrido (SEM) y análisis elemental mediante medidas de espectroscopia de energía dispersiva (EDX). El estudio eléctrico se realizó mediante medidas de voltaje en función de la corriente a temperatura ambiente y posterior cálculo de la resistividad volumétrica. El estudio del efecto percolativo se llevó a cabo mediante el cálculo del volumen crítico y de los exponentes críticos en cada una de las fases aislante y conductora, usando el modelo de Kussy [1] y el modelo de respuesta no lineal semi clásica Random Resitor cum Tunelling bond Network (RRTN) [2] contrastando los exponentes críticos, con los encontrados en la literatura.
Reaching High-Need Youth Populations With Evidence-Based Sexual Health Education in California
Authors: Campa Mary I. , Leff Sarah Z. , Tufts Margaret 
Published: February 2018

Objectives. To explore the programmatic reach and experience of high-need adolescents who received sexual health education in 3 distinct implementation settings (targeted-prevention settings, traditional schools, and alternative schools) through a statewide sexual health education program. Methods. Data are from youth surveys collected between September 2013 and December 2014 in the California Personal Responsibility Education Program. A sample of high-need participants (n = 747) provided data to examine the impact of implementation setting on reach and program experience. Results. Implementation in targeted-prevention settings was equal to or more effective at providing a positive program experience for high-need participants. More than 5 times as many high-need participants were served in targeted-prevention settings compared with traditional schools. Reaching the same number of high-need participants served in targeted-prevention settings over 15 months would take nearly 7 years of programming in traditional schools. Conclusions. To maximize the reach and experience of high-need youth populations receiving sexual health education, state and local agencies should consider the importance of implementation setting. Targeted resources and efforts should be directed toward high-need young people by expanding beyond traditional school settings.
Effects of morphological change on fluvial flood patterns evaluated by a hydro-geomorphological model
Authors: Hou Jingming , Han Hao , Li Zhanbin , Guo Kaihua , Qin Yi 
Published: February 2018

Abstract
High aggradation and degradation in a river induced by the last flood event will raise and decrease the risk of an upcoming flood event, respectively. To quantitatively investigate this effect, a two-dimensional (2D) hydrodynamic model coupled with a sediment transport the river-bed evolution models is developed. After being validated against two experimental benchmark tests, the model is applied to simulate the effects of the morphological change on flood patterns. It is found in two experimental scale tests that bed evolution may have substantial influence on water level, which is directly related to flood risk extent. In the application of the model computing a realistic flood event in Bayangaole Reach of Yellow River, the results show that the water surface level becomes lower for an upcoming flood event with the same hydrograph, indicating the flood risk considerably decreases in the next flood event. The effect of a perturbed bed therefore could be of significance for fluvial flood over a movable bed and therefore to flood risk management.
Możliwość zastosowania teorii decyzji do zagadnień etycznych w ujęciu Klemensa Szaniawskiego
Authors: Majewska Lucyna 
Published: February 2018

Klemens Szaniawski, mimo że kojarzony z filozofią nauki i logiką, w swoich rozważaniach zajmuje się również teorią decyzji i wskazuje na jej związek z zagadnieniami etycznymi. Wychodząc od pojęciowego i językowego powiązania między teorią decyzji a etyką, poszukuje dalszych ich relacji, które poddaje analizie. W artykule pokazano przydatność twierdzeń teorii decyzji nie tylko do analizy zagadnień etycznych, ale także wyborów działania (podejmowania decyzji), które ściśle są związane z podmiotem etycznym. Po pierwsze, wskazano, że pojęcie racjonalności jest istotnym elementem wiążącym proces decyzyjny z etyką. Po drugie, pojęcie decyzji zawiera dwa elementy: wybór działania i postanowienie jego realizacji. Decyzja jest zrelatywizowana do celu, cel zaś determinuje działanie podmiotu, a sam wybór uwzględnia przekonania i wartościowanie decydenta. Po trzecie, rozumienie pojęcia decyzji wiąże się z podmiotem, który posiada pewien charakter i formuje go podczas podejmowania decyzji. Co więcej, w konkretnych decyzjach podmiotu, uwidoczniają się jego cele, środki i motywy. Dlatego włączenie teorii decyzji do analizy osobowości podmiotu i definiowania tożsamości pozwala na uzyskanie wielostronnej wiedzy na temat człowieka. W nowym spojrzeniu na zagadnienie całego procesu decyzyjnego wskazano na możliwość pragmatycznego zastosowania pojęć teorii decyzji w etyce. By określić przydatność aparatury pojęciowej teorii decyzji w praktyce, posłużono się przykładami zaczerpniętymi z nauk prawnych i medycyny.
Macrophage Migration Inhibitory Factor - A Favorable Marker in Inflammatory Diseases?
Authors: Hertelendy Johannes , Reumuth Georg , Simons David , Stoppe Christian , Kim Bong-Sung , Stromps Jan-Philipp , Fuchs Paul C. , Bernhagen Jurgen , Pallua Norbert , Grieb Gerrit 
Published: February 2018

Background:
Macrophage migration inhibitory factor (MIF) was firstly described in the
1960s as a pleiotropic cytokine affecting a variety of immune cells. Different physiological functions
mainly involving inflammatory reactions such as chemokine-like function and regulating systemic
stress responses have been reported.

Objective:
In several clinical studies the use of MIF as a biomarker has been investigated promising
support for diseases with an inflammatory aspect such as sepsis, systemic infections and autoimmune
diseases. This article in detail reviews clinical data and evaluates the function as biomarker focusing
on inflammatory and autoimmune diseases.

Conclusion:
Recent studies suggest MIF to be a marker for different inflammatory diseases and might
serve as therapeutic target in the future.
Peptides and their Metal Complexes in Neurodegenerative Diseases: from Structural Studies to Nanomedicine Prospects
Authors: Trapani Giuseppe , Satriano Cristina , La Mendola Diego 
Published: February 2018

Background:
The metal ions dyshomeostasis is increasingly recognized to play a crucial role
in the development of aging-related neurodegenerative diseases. Metal trafficking in the brain is related
to proteins regulating both uptake and efflux of metals in neurons. Different pathways may occur, depending
on specific binding features of metallo-protein complexes. In particular, copper, zinc and iron
are recognized to influence the biochemistry of proteins involved in neurodegeneration (for instance Aβ
and α-synuclein), as well as those playing a crucial role in neuronal development and efficiency (neurotrophins).
Nowadays the application of peptide-based drugs is widespread for different pathologies,
but the short lifetime in vivo due to proteolysis and other shortcomings still limit their use.

Methods:
A structured search was performed about the state of the art on: i) peptidomimetic approaches
used to obtain peptides mimicking the metal binding activities of proteins involved in neurons
survival, ii) peptide-based nanostructures, as promising biomaterials in tissue engineering and substrates
for neurites outgrowth and synapses formation.

Results:
Recent developments on metal-binding peptides and peptide nanostructures for therapeutic
application in neurodegenerative diseases are reviewed, showing as metal ions interaction may affect
structural and biological properties of different proteins involved in neurodegenerative diseases.

Conclusion:
This review provides a survey on peptides able to mimic some biofunctional activities of
the whole protein, e.g., the binding features to metal ions, thus highlighting their promising potentialities
as new, more effective, therapeutics. The integration of such peptides into multifunctional nanoplatforms
can be a smart route for the development of biomaterials scaffolds and nanomedicine applications.
Predictive and Descriptive CoMFA Models: The Effect of Variable Selection
Authors: Sepehri Bakhtyar , Omidikia Nematollah , Kompany-Zareh Mohsen , Ghavami Raouf 
Published: February 2018

Aims & Scope: In this research, 8 variable selection approaches were used to investigate
the effect of variable selection on the predictive power and stability of CoMFA models.

Materials & Methods:
Three data sets including 36 EPAC antagonists, 79 CD38 inhibitors and 57
ATAD2 bromodomain inhibitors were modelled by CoMFA. First of all, for all three data sets,
CoMFA models with all CoMFA descriptors were created then by applying each variable selection
method a new CoMFA model was developed so for each data set, 9 CoMFA models were built.
Obtained results show noisy and uninformative variables affect CoMFA results. Based on created
models, applying 5 variable selection approaches including FFD, SRD-FFD, IVE-PLS, SRD-UVEPLS
and SPA-jackknife increases the predictive power and stability of CoMFA models significantly.

Result & Conclusion:
Among them, SPA-jackknife removes most of the variables while FFD retains
most of them. FFD and IVE-PLS are time consuming process while SRD-FFD and SRD-UVE-PLS
run need to few seconds. Also applying FFD, SRD-FFD, IVE-PLS, SRD-UVE-PLS protect CoMFA
countor maps information for both fields.
THE ANALYSIS OF FACTORS AFFECT INCOME SMOOTHING ON MISCELLANEOUS INDUSTRY COMPANIES LISTED ON INDONESIA STOCK EXCHANGE
Authors: Anwar Arfianti Novita , Chandra Teddy 
Published: February 2018

<p>The objective of this research is to identify the factors which have influence on income smoothing at Miscellaneous Industry companies listed on Indonesian Stock Exchange period 2009-2013. Independent variables of this research include Return on Asset (ROA), Company Size, Dividend Payout Ratio (DPR), Debt to Equity Ratio (DER), and Financial Leverage while the dependent variable is income smoothing. The sample used in this study is 29 Miscellaneous Industry companies listed on the Indonesian Stock Exchange within a period of five years beginning in 2009 until 2013 with the selection method of purposive sampling. To identify the companies doing income smoothing, the Eckel Index was used. Statistical analysis used in this study uses descriptive statistics, multiple linear regressions and discriminant analysis. The results show that partially only company size and dividend payout ratio have significant impact on income smoothing meanwhile Return on Assets, Debt to Equity Ratio, Financial leverage did not show significant influence on income smoothing practices. The result of discriminant analysis shows there is significant difference of Return On Assets between income smoothing and non-smoothing company. </p><p><em>Penelitian ini ditujukan untuk mengidentifikasi faktor-faktor yang mempengaruhi perataan laba pada perusahaan aneka industri yang terdaftar di Bursa Efek Indonesia pada periode 2009 – 2013. Variabel bebas yang digunakan dalam penelitian ini mencakup Return on Asset (ROA), Ukuran Perusahaan, Dividend Payout Ratio (DPR), Debt to Equity Ratio (DER) dan Financial Leverage, dengan variabel terikat perataan laba. Perusahaan yang menjadi sampel penelitian terdiri dari 29 perusahaan aneka industri yang dipilih dengan menggunakan metode purposive sampling. Untuk mengidentifikasi perusahaan-perusahaan yang melakukan praktik perataan laba dipergunakan indeks Eckel. Alat analisis yang dipergunakan untuk melakukan analisis deskriptif kuantitatif adalah analisis linear berganda dan analisis diskriminan. Hasil penelitian menunjukkan bahwa seluruh variabel bebas yang dipergunakan mampu menjelaskan proses perataan laba yang dilakukan oleh perusahaan dan yang memiliki pengaruh signifikan adalah ukuran perusahaan dan Dividend Payout Ratio. Sementara hasil dari analisis diksriminan menunjukkan bahwa terdapat perbedaan Return on Asset antara perusahaan yang melakukan praktik perataan laba dengan perusahaan yang tidak melakukan perataanlaba</em></p>
PENGEMBANGAN MULTIMEDIA INTERAKTIF MENGGUNAKAN MICROSOFT POWER POINT DALAM PEMBELAJARAN MATEMATIKA KELAS X MA KM MUHAMMADIYAH PADANG PANJANG
Authors: Yusri Radhya , Husaini Al 
Published: February 2018

<em>Pemamfaatan media pembelajaran di MA KM Muhammadiyah Padangpanjang belum optimal, salah satu usaha yang dapat dilakukan untuk mengoptimalkan fasilitas yang ada adalah dengan mengembangkan suatu media pembelajaran berupa multimedia interaktif menggunakan Microsoft Power Point yang dikemas dalam CD (Compact Disc). Model pengembangan menggunakan model pengembangan 4-D yaitu define, design, develop dan disseminate. Hasil pengembangan menunjukkan bahwa media pembelajaran dengan multimedia interaktif menggunakan Microsoft Power Point dalam pembelajaran matematika kelas X MA KM Muhammadiyah Padangpanjang memenuhi kriteria media yang baik. Pada aspek kevalidan, kualitas isi dan tujuan pembelajaran media pembelajaran yang telah dibuat memperoleh penilaian 82 % dengan kategori sangat valid<strong> </strong>sedangkan dari sisi media itu sendiri memperoleh penilaian 82 % dengan kategori sangat valid. Sedangkan pada aspek kepraktisan media pembelajaran ini memperoleh penilaian 78 % dengan kategori praktis.</em>
ANALISA KEPUASAN SISWA TERHADAP SARANA PRASARANA SEKOLAH MENGGUNAKAN FUZZY LOGIC
Authors: Hamdi Khairil 
Published: February 2018

<p><span style="font-family: Times New Roman; font-size: medium;">Penelitian ini dilakukan untuk mengetahui tingkat kepuasan siswa terhadap sarana prasarana yang telah dimiliki oleh sekolah, dengan </span><span style="font-family: Times New Roman; font-size: medium;">metode </span>logika <em>fuzzy </em>model mamdani yang dibantu oleh <em>software matlab</em>. <em>F</em><em>uzzy logic</em> serta perhitungan manual. jika dibandingkan dengan penggunaan himpunan tegas (<em>crisp</em>) penggunaan logika <em>fuzzy</em> merupakan sistem yang <em>linguistik</em> sehingga lebih mudah dan efisien didalam mengkomunikasikannya. Sebagai input yang digunakan adalah 5 variabel yaitu bangunan sekolah, ruang belajar, laboratorium, perpustakaan dan sarana ibadah ditambah tingkat kepuasan sebagai <em>output. </em>Dari hasil yang dicapai nanti akan menggambarkan nilai kepuasan pada setiap variable sehingga dari pengolahan matlab akan menemukan nilai ouput yang dicapai.</p><p> </p>
Adaptasi Ikan Timpakul (Perioptholmodon schlosseri) di Habitat terganggu Muara Sungai Barito, Kalimantan Selatan
Authors: MUHAMAT Muhamat , SANTOSO Heri Budi , HIDAYATURRAHMAH Hidayaturrahmah 
Published: February 2018

Timpakul fish (Periophthalmodon schlosseri) is a kind of fish which able to live long in the land. One of the habitats of the fish is Barito river estuary. The development of land conversion which high enough at Barito river estuary into the area of fishponds and rice fields cause P. schlosseri must adapt to the environment disturbed. The research aimed to determine the adaptation of P. schlosseri in fishponds and rice fields habitats in Barito river estuary. The research is conducted by using the method of line transect, that is by walking in the area of rice fields and fishponds in Barito river estuary with the object of observation consisted of nest and activity of P. schlosseri. The results of observation showed that the density of P. schlosseri was relatively small at 0.54 individual/hectare in paddy fields areal and 0.84 individual/hectare the area of aquaculture. The relatively low density of fish was caused by nature solitary and carnivorous fish. The adaptation of P. schlosseri in the areas of fishponds and paddy fields could be successful because it was supported by adequate food source, that were crab, shrimp, frog and small fish and predators were relatively few.
Keywords: Adaptation, Barito river estuary, disturbed habitat, Periophthalmodon schlosseri
A Reconfiguração do Conceito Jurídico de Soberania no Contexto da Sociedade Internacional Globalizada
Authors: Klein Junior Paulo , Olsson Giovanni 
Published: February 2018

A RECONFIGURAÇÃO DO CONCEITO JURÍDICO DE SOBERANIA NO CONTEXTO DA SOCIEDADE INTERNACIONAL GLOBALIZADA THE RECONFIGURATION OF THE LEGAL CONCEPT OF SOVEREIGNTY IN THE CONTEXT OF GLOBALIZED INTERNATIONAL SOCIETY Paulo Klein Junior*Giovanni Olsson** RESUMO: O estudo objetiva compreender a reconfiguração do conceito jurídico de soberania no contexto da sociedade internacional globalizada. Essa temática constitui uma questão contemporânea, uma vez que retrata situações em curso na sociedade internacional. O tratado assinado após a Guerra dos Trinta Anos, chamado de Paz de Vestfália, rompeu com o sistema medieval e constituiu porta de entrada para a Modernidade. A partir de então, o conceito de soberania foi se desenvolvendo progressivamente. Após as Guerras Mundiais, a globalização despontou, bem como surgiram novos atores internacionais, que reconfiguraram a sociedade internacional. Todos esses fatores colocaram em xeque a soberania estatal fixada no advento da Idade Moderna, proporcionando uma nova compreensão do que é soberania, bem como uma possível readequação de seu conceito. A metodologia utilizada na presente pesquisa consiste no método dedutivo, pela técnica de pesquisa bibliográfica. PALAVRAS-CHAVE: Soberania. Globalização. Sociedade Internacional. ABSTRACT: The study aims to understand the reconfiguration of the legal concept of sovereignty in the context of globalized international society. This subject constitutes a contemporary question, once it portraits ongoing situations in the international society. The treaty signed after the Thirty Years’ War, called Peace of Westphalia, broke up with the medieval system, leading to Modernity. From this moment on, the concept of sovereignty was being developed progressively. After the two World Wars, globalization has emerged, as well as new international actors that reconfigured international society. All these issues challenge State’s sovereignty emerged at the advent of Modern Age, making possible a new comprehension of what sovereignty is, and also possible reshaping of its concept. The methodology used in this work consists of the deductive method, through bibliographic research. KEYWORDS: Sovereignty. Globalization. International Society. SUMÁRIO: Introdução. 1 O Tratado de Vestfália e a Construção do Conceito Moderno de Soberania. 2 A Sociedade Internacional Globalizada. 3 A Soberania Revisitada no Contexto Contemporâneo. Considerações Finais. Referências._________________________* Mestrando em Direito pela Universidade Comunitária da Região de Chapecó, Santa Catarina. Pesquisador bolsista CAPES. Membro do Grupo de Pesquisa CNPq Relações Internacionais, Direito e Poder.** Doutor em Direito pela Universidade Federal de Santa Catarina (UFSC). Professor Permanente do Mestrado em Direito da Universidade Comunitária da Região de Chapecó, Santa Catarina.