bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sound and robust solid modeling via exact real arithmetic and continuity
Authors: Sherman Benjamin , Michel Jesse , Carbin Michael 
Published: July 2019

Algorithms for solid modeling, i.e., Computer-Aided Design (CAD) and computer graphics, are often specified on real numbers and then implemented with finite-precision arithmetic, such as floating-point. The result is that these implementations do not soundly compute the results that are expected from their specifications.
We present a new library, StoneWorks, that provides sound and robust solid modeling primitives. We implement StoneWorks in MarshallB, a pure functional programming language for exact real arithmetic in which types denote topological spaces and functions denote continuous maps, ensuring that all programs are sound and robust. We developed MarshallB as an extension of the Marshall language.

We also define a new shape representation,
compact representation
(
K-rep
), that enables constructions such as Minkowski sum and analyses such as Hausdorff distance that are not possible with traditional representations. K-rep is a nondeterminism monad for describing all the points in a shape.

With our library, language, and representation together, we show that short StoneWorks programs can specify and execute sound and robust solid modeling algorithms and tasks.
Wavefront Field Mapping Reveals a Physiologic Network Between Drivers Where Ablation Terminates Atrial Fibrillation
Authors: Leef George , Shenasa Fatemah , Bhatia Neal K. , Rogers Albert J. , Sauer William , Miller John M. , Swerdlow Mark , Tamboli Mallika , Alhusseini Mahmood I. , Armenia Erin , Baykaner Tina , Brachmann Johannes , Turakhia Mintu P. , Atienza Felipe , Rappel Wouter-Jan , Wang Paul J. , Narayan Sanjiv M. 
Published: July 2019

Background:
Localized drivers are proposed mechanisms for persistent atrial fibrillation (AF) from optical mapping of human atria and clinical studies of AF, yet are controversial because drivers fluctuate and ablating them may not terminate AF. We used wavefront field mapping to test the hypothesis that AF drivers, if concurrent, may interact to produce fluctuating areas of control to explain their appearance/disappearance and acute impact of ablation.

Methods:
We recruited 54 patients from an international registry in whom persistent AF terminated by targeted ablation. Unipolar AF electrograms were analyzed from 64-pole baskets to reconstruct activation times, map propagation vectors each 20 ms, and create nonproprietary phase maps.

Results:

Each patient (63.6±8.5 years, 29.6% women) showed 4.0±2.1 spatially anchored rotational or focal sites in AF in 3 patterns. First, a single (type I; n=7) or, second, paired chiral-antichiral (type II; n=5) rotational drivers controlled most of the atrial area. Ablation of 1 to 2 large drivers terminated all cases of types I or II AF. Third, interaction of 3 to 5 drivers (type III; n=42) with changing areas of control. Targeted ablation at driver centers terminated AF and required more ablation in types III versus I (
P
=0.02 in left atrium).

Conclusions:
Wavefront field mapping of persistent AF reveals a pathophysiologic network of a small number of spatially anchored rotational and focal sites, which interact, fluctuate, and control varying areas. Future work should define whether AF drivers that control larger atrial areas are attractive targets for ablation.
Donor Simvastatin Treatment in Heart Transplantation
Authors: Nykänen Antti I. , Holmström Emil J. , Tuuminen Raimo , Krebs Rainer , Dhaygude Kishor , Kankainen Matti , Jokinen Janne J. , Lommi Jyri , Helanterä Ilkka , Räisänen-Sokolowski Anne , Syrjälä Simo O. , Lemström Karl B. 
Published: July 2019

Background:
Ischemia-reperfusion injury may compromise the short-term and long-term prognosis after heart transplantation. Experimental studies show that simvastatin administered to the organ donor is vasculoprotective and inhibits cardiac allograft ischemia-reperfusion injury.

Methods:
Eighty-four multiorgan donors were randomly assigned to receive 80 mg of simvastatin (42 donors) via nasogastric tube after declaration of brain death and upon acceptance as a cardiac donor, or to receive no simvastatin (42 donors). The primary efficacy end point was postoperative plasma troponin T and I levels during the first 24 hours after heart transplantation. Secondary end points included postoperative hemodynamics, inflammation, allograft function, rejections and rejection treatments, and mortality.

Results:

Organ donor simvastatin treatment significantly reduced the heart recipient plasma levels of troponin T by 34% (14 900 ± 12 100 ng/L to 9800 ± 7900 ng/L,
P
=0.047), and troponin I by 40% (171 000 ± 151 000 ng/L to 103 000 ± 109 000 ng/L,
P
=0.023) at 6 hours after reperfusion, the levels of NT-proBNP (N-terminal pro-B-type natriuretic peptide) by 36% (32 800 ± 24 300 ng/L to 20 900 ± 15 900 ng/L;
P
=0.011) at 1 week, and the number of rejection treatments with hemodynamic compromise by 53% within the first 30 days (
P
=0.046). Donor simvastatin treatment did not affect donor lipid levels but was associated with a specific transplant myocardial biopsy gene expression profile, and a decrease in recipient postoperative plasma levels of CXCL10 (C-X-C motif chemokine 10), interleukin-1α, placental growth factor, and platelet-derived growth factor-BB. Postoperative hemodynamics, biopsy-proven acute rejections, and mortality were similar. No adverse effects were seen in recipients receiving noncardiac solid organ transplants from simvastatin-treated donors.

Conclusions:
Donor simvastatin treatment reduces biomarkers of myocardial injury after heart transplantation, and—also considering its documented general safety profile—may be used as a novel, safe, and inexpensive adjunct therapy in multiorgan donation.

Clinical Trial Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT01160978.
The End of War: How a Robust Marketplace and Liberal Hegemony Are Leading to Perpetual World Peace
Authors: Mousseau Michael 
Published: July 2019

Abstract
Permanent world peace is beginning to emerge. States with developed market-oriented economies have foremost interests in the principle of self-determination of all states as the foundation for a robust global marketplace. War among these states, even making preparations for war, is not possible, because they are in a natural alliance to preserve and protect the global order. Among other states, weaker powers, fearing those that are stronger, tend to bandwagon with the relatively benign market-oriented powers. The result is a powerful liberal global hierarchy that is unwittingly, but systematically, buttressing states' embrace of market norms and values, moving the world toward perpetual peace. Analysis of voting preferences of members of the United Nations General Assembly from 1946 to 2010 corroborates the influence of the liberal global hierarchy: states with weak internal markets tend to disagree with the foreign policy preferences of the largest market power (i.e., the United States), but more so if they have stronger rather than weaker military and economic capabilities. Market-oriented states, in contrast, align with the market leader regardless of their capabilities. Barring some dark force that brings about the collapse of the global economy (such as climate change), the world is now in the endgame of a five-century-long trajectory toward permanent peace and prosperity.
Role of Sea Surface Temperatures in Forcing Circulation Anomalies Driving U.S. Great Plains Pluvial Years
Authors: Flanagan Paul X. , Basara Jeffrey B. , Furtado Jason C. , Martin Elinor R. , Xiao Xiangming 
Published: July 2019

Abstract
In the U.S. Great Plains (GP), diagnosing precipitation variability is key in developing an understanding of the present and future availability of water in the region. Building on previous work investigating U.S. GP pluvial years, this study uses ERA twentieth century (ERA-20C) reanalysis data to investigate key circulation anomalies driving GP precipitation anomalies during a subset of GP pluvial years (called in this paper Pattern pluvial years). With previous research showing links between tropical Pacific sea surface temperature (SST) anomalies and GP climate variability, this study diagnoses the key circulation anomalies through an analysis of SSTs and their influence on the atmosphere. Results show that during Pattern southern Great Plains (SGP) pluvial years, central tropical Pacific SST anomalies are coincident with key atmospheric anomalies across the Pacific basin and North America. During northern Great Plains (NGP) Pattern pluvial years, no specific pattern of oceanic anomalies emerges that forces the circulation anomaly feature inherent in specific NGP pluvial years. Utilizing the results for SGP pluvial years, a conceptual model is developed detailing the identified pathway for the occurrence of circulation patterns that are favorable for pluvial years over the SGP. Overall, results from this study show the importance of the identified SGP atmospheric anomaly signal and the potential for predictability of such events.
Improvements to the Assimilation of Doppler Radial Winds for Convection-Permitting Forecasts of a Heavy Rain Event
Authors: Lippi Donald E. , Carley Jacob R. , Kleist Daryl T. 
Published: July 2019

AbstractThis work describes developments to improve the Doppler radial wind data assimilation scheme used in the National Centers for Environmental Prediction (NCEP) Gridpoint Statistical Interpolation (GSI) data assimilation system with a focus on convection-permitting, 0–18-h forecasts of a heavy precipitation single case study. This work focuses on two aspects: 1) the extension of the radial wind observation operator to include vertical velocity and 2) a refinement of the radial wind super-observation processing. The refinement includes reducing the magnitude of observation smoothing and allowing observations from higher scan angles into the analysis with the intent to improve the assimilation of the radar data for operational, convection-permitting models. The results of this study demonstrate that there is sensitivity to the refinement in super-observation settings. The inclusion of vertical velocity in the observation operator is shown to have a neutral to slightly positive impact on the forecast. Results from this study are suggested to be used as a foundation to prioritize future research into the effective assimilation of radial winds in an operational setting.
Novel Method of Atrial Fibrillation Case Identification and Burden Estimation Using the MIMIC-III Electronic Health Data Set
Authors: Ding Eric Y. , Albuquerque Daniella , Winter Michael , Binici Sophia , Piche Jaclyn , Bashar Syed Khairul , Chon Ki , Walkey Allan J. , McManus David D. 
Published: July 2019

Background: Atrial fibrillation (AF) portends poor prognoses in intensive care unit patients with sepsis. However, AF research is challenging: Previous studies demonstrate that International Classification of Disease ( ICD) codes may underestimate the incidence of AF, but chart review is expensive and often not feasible. We aim to examine the accuracy of nurse-charted AF and its temporal precision in critical care patients with sepsis. Methods: Patients with sepsis with continuous electrocardiogram (ECG) waveforms were identified from the Medical Information Mart for Intensive Care (MIMIC-III) database, a de-identified, single-center intensive care unit electronic health record (EHR) source. We selected a random sample of ECGs of 6 to 50 hours’ duration for manual review. Nurse-charted AF occurrence and onset time and ICD-9-coded AF were compared to gold-standard ECG adjudication by a board-certified cardiac electrophysiologist blinded to AF status. Descriptive statistics were calculated for all variables in patients diagnosed with AF by nurse charting, ICD-9 code, or both. Results: From 142 ECG waveforms (58 AF and 84 sinus rhythm), nurse charting identified AF events with 93% sensitivity (95% confidence interval [CI]: 87%-100%) and 87% specificity (95% CI: 80%-94%) compared to the gold standard manual ECG review. Furthermore, nurse-charted AF onset time was within 1 hour of expert reader onset time for 85% of the reviewed tracings. The ICD-9 codes were 97% sensitive (95% CI: 88-100%) and 82% specific (95% CI: 74-90%) for incident AF during admission but unable to identify AF time of onset. Conclusion: Nurse documentation of AF in EHR is accurate and has high precision for determining AF onset to within 1 hour. Our study suggests that nurse-charted AF in the EHR represents a potentially novel method for AF case identification, timing, and burden estimation.
The effect of different optical zone diameters on the results of high-order aberrations in femto-laser-assisted in situ keratomileusis
Authors: Özülken Kemal , Kaderli Ahmet 
Published: July 2019

Purpose: To evaluate the postoperative high-order aberration differences of femto-LASIK surgery in 6.5 and 7 mm optic zones. Patients and Methods: We retrospectively reviewed 80 eyes of 40 patients with myopia or myopia with astigmatism who underwent femtosecond LASIK surgery. Q values, z3, 3 (h. trefoil), z3, –3 (v. trefoil), z3, 1 (h. coma), z3, –1 (vertical coma), z4, 0 (spherical aberration), z5, –1 (second other v. coma), aberration coefficients were evaluated 3 months after surgery. Central corneal thicknesses, intraocular pressures, patient ages and genders, optical zone diameters and ablation depths are collected from patients’ medical records. Results: The mean age was 28.4 ± 0.69 years (range, 20–47 years). Lower z4, 0 spherical aberrations and aberration coefficient values were associated with larger optical zones (7 mm) (z4, 0 spherical aberrations = 1.25, p = 0.01; coefficient value = –1.21, p < 0.01). Although a smaller optical zone (6.5 mm) was associated with an increase in most of the wave-front aberration variables, measurements were not statistically different between the two groups other than z4, 0 spherical aberrations and aberration coefficients. Discussion: LASIK treatment with 6.5 and 7 mm optical zones is safe and effective for correcting myopia and myopic astigmatism and has statistically similar visual outcomes. Moreover, larger optical zone (7 mm) was found to be associated with lower spherical aberration induction and smaller aberration coefficient values compared to 6.5 mm optical zone. This can be important for decision-making in femto-LASIK surgery for better postoperative results.
Comparative evaluation of postoperative health status and functional outcome in patients treated with either proximal femoral nail or hemiarthroplasty for unstable intertrochanteric fracture
Authors: Ucpunar Hanifi , Camurcu Yalkin , Çöbden Adem , Sofu Hakan , Kis Mehmet , Demirel Huseyin 
Published: July 2019

Purpose: This study aimed to compare functional recovery and change in morbidity status from the preoperative levels among patients who underwent two different surgical treatments for unstable intertrochanteric fracture. Methods: This retrospective comparative study enrolled 140 patients (aged >80 years) who were referred to two hospitals. Of these, 64 were treated using proximal femoral nail (PFN) and 76 were treated using hemiarthroplasty (HA). To evaluate functional recovery, primary outcome measures were cumulative illness rating scale (CIRS) score to evaluate changes in morbidity status, activity of daily living (ADL) index, and mobility scores. Results: The proportion of patients who experienced increased CIRS scores in the HA group was higher at the 3-month follow-up ( p = 0.02) but similar at the 6-month follow-up ( p = 0.2) in comparison to the PFN group. Treatment with HA, American Society of Anesthesiologists scores of 3–4, and lower, preoperative ADL indexes were the major predictors of increased postoperative CIRS score. Impaired ambulatory ability and the need for walking aids were significantly higher in the PFN group at the 3-month follow-up ( p = 0.01 and p = 0.02, respectively) but similar at the 6-month follow-up with respect to the HA group. PFN treatment and high patient body mass index were the major predictors of decreased ambulatory ability at postoperative 3 months. Conclusion: HA has several advantages, including early mobilization and decreased dependency. However, it is associated with greater blood loss, a higher need for blood transfusion, and longer surgical duration than PFN, all of which are predisposing factors for significantly higher risk of reduced CIRS scores.
The WORC Index and Predicting Treatment Failure in Patients Undergoing Primary Arthroscopic Rotator Cuff Repair
Authors: Herring Matthew J. , White Melissa , Braman Jonathan P. 
Published: July 2019

Background: Rotator cuff tears are common injuries that are reliably treated with arthroscopic repair, producing good to excellent results. The Western Ontario Rotator Cuff (WORC) index is a validated disease-specific instrument used to assess patient outcomes; however, no study to date has correlated WORC index with treatment failure. Purpose: To evaluate the WORC index as a predictor for successful treatment in arthroscopic rotator cuff repair. An additional purpose was to identify patient and tear characteristics associated with risk of treatment failure. Study Design: Case-control study; Level of evidence, 3. Methods: This study reviewed a total of 500 patients who underwent arthroscopic rotator cuff repair with a minimum of 2-year follow-up. Patient charts were reviewed for treatment failures, defined as persistent or recurrent shoulder pain or weakness, leading to further workup and identification of a failure to heal or recurrent tear by magnetic resonance imaging. Patient demographic and comorbidity data were gathered and correlated with risk of failure. All patients completed WORC questionnaires, and scores were correlated with risk of treatment failure. Results: There were 28 (5.6%) treatment failures at a median 28 weeks (SD, 42 weeks) postoperatively. Patients claiming workers’ compensation were 3.21 times more likely (odds ratio; P = .018) to fail treatment. Posterior interval tears (those including infraspinatus) were 3.14 times more likely ( P = .01) to fail than anterior interval tears. Tear size was associated with treatment failure; the odds of failure was 3.24 for a 2-tendon tear and 5.83 for a 3-tendon tear ( P = .03). Tears involving the nondominant arm were associated with an increased risk of failure by a factor of 3.04 (95% CI, 1.01-9.11; P = .047). A WORC score ≥80 was associated with a 95% probability of treatment success at 1 year. Conclusion: After arthroscopic rotator cuff repair, patients with WORC scores ≥80 at 1 year have a 95% probability of successful treatment and likely do not benefit from continued follow-up visits. Furthermore, several risk factors were identified that may influence outcomes after rotator cuff repair, including workers’ compensation, location of tear, tear size, and hand dominance.
Static Lateral Tibial Plateau Subluxation Predicts the Grade of Rotatory Knee Laxity in ACL-Deficient Knees
Authors: Lian Jayson , Novaretti João V. , Sheean Andrew J. , Patel Neel K. , Popchak Adam , Musahl Volker 
Published: July 2019

Objectives: In anterior cruciate ligament-deficient (ACL-D) knees, injury pattern and bony morphology have been shown to influence both static anterior tibial subluxation relative to the femur and dynamic rotatory knee laxity. Therefore, the relationship between static anterior tibial subluxation and dynamic rotatory knee laxity was investigated. The goal of this study was to determine if static tibial subluxation as measured on magnetic resonance imaging (MRI) was associated with the grade of rotatory knee laxity in ACL-D knees. Methods: Two-hundred and fifty-eight knees underwent preoperative, image-guided assessment of lateral knee compartment translation during quantitative pivot shift (QPS). Subluxations of the medial and lateral tibial plateaus were measured on preoperative MRI in a subset of primary ACL-D knees meeting criteria for high-grade (QPS > 5.2 mm) and low-grade (QPS < 2.4 mm) rotatory laxity. Tibial subluxations on MRI were compared between patients with high- and low-grade rotatory laxity using pairwise t-test, and analyzed using uni- and multivariate logistic regression. Significance was set at p<0.05. Results: On MRI, greater anterior subluxation of the lateral tibial plateau was observed in patients with high-grade compared to low-grade rotatory knee laxity (4.5 mm vs. 2.3 mm; p<0.05). No similar relationship was observed for the medial tibial plateau (-0.9 mm vs. -0.4 mm; p>0.05). Univariate logistic regression demonstrated that static subluxation of the lateral tibial plateau was associated with high-grade rotatory knee laxity (Odds ratio [OR] 1.2; p<0.05). An optimal cut-off of 2.95 mm of static lateral tibial subluxation was associated with high-grade rotatory knee laxity (sensitivity: 75%; specificity: 63%). Lateral meniscus injury was the first variable to enter a multivariate regression analysis and proved to be most associated with high-grade rotatory knee laxity ([OR] 6.8; p < 0.05). When lateral meniscus injury was excluded from multivariate regression analysis, static anterior subluxation of the lateral tibial plateau alone was associated with high-grade rotatory knee laxity ([OR] 1.2; p<0.05). Conclusion: Data from this MRI study of two distinct rotatory knee laxity groups showed that static anterior subluxation of the lateral tibial plateau of 2.95 mm or greater was associated with high-grade rotatory knee laxity, and each millimeter increase of lateral tibial plateau subluxation was associated with a 1.2-fold odds of high-grade rotatory knee laxity. Anterior subluxation of the lateral tibial plateau on MRI was not independently associated with high-grade rotatory knee laxity in the presence of concomitant lateral meniscus injury. Static measurements made pre-operatively may aid in predicting high-grade rotatory knee laxity and refining the indications for individualized knee surgery.