bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prognostic 11 long noncoding RNA expression signature for breast invasive carcinoma
Authors: He Yuting , Li Xingsong , Meng Yuhuan , Fu Shuying , Cui Ying , Shi Yong , Du Hongli 
Published: May 2019

AbstractBreast cancer, the most common cancer in women worldwide, is associated with high mortality. The long non‐coding RNAs (lncRNAs) with a little capacity of coding proteins is playing an increasingly important role in the cancer paradigm. Accumulating evidences demonstrate that lncRNAs have crucial connections with breast cancer prognosis while the studies of lncRNAs in breast cancer are still in its primary stage. In this study, we collected 1052 clinical patient samples, a comparatively large sample size, including 13 159 lncRNA expression profiles of breast invasive carcinoma (BRCA) from The Cancer Genome Atlas database to identify prognosis‐related lncRNAs. We randomly separated all of these clinical patient samples into training and testing sets. In the training set, we performed univariable Cox regression analysis for primary screening and played the model for Robust likelihood‐based survival for 1000 times. Then 11 lncRNAs with a frequency more than 600 were selected for prediction of the prognosis of BRCA. Using the analysis of multivariate Cox regression, we established a signature risk‐score formula for 11 lncRNA to identify the relationship between lncRNA signatures and overall survival. The 11 lncRNA signature was validated both in the testing and the complete set and could effectively classify the high‐/low‐risk group with different OS. We also verified our results in different stages. Moreover, we analyzed the connection between the 11 lncRNAs and the genes of ESR1, PGR, and Her2, of which protein products (ESR, PGR, and HER2) were used to classify the breast cancer subtypes widely. The results indicated correlations between 11 lncRNAs and the gene of PGR and ESR1. Thus, a prognostic model for 11 lncRNA expression was developed to classify the BRAC clinical patient samples, providing new avenues in understanding the potential therapeutic methods of breast cancer.
Variability, morphometrics, and co‐variation of the os lacrimale in Cervidae
Authors: Schilling Ann‐Marie , Calderón‐Capote María C. , Rössner Gertrud E. 
Published: May 2019

AbstractIn Ruminantia, the lacrimal bone forms a considerable part of the facial skeleton, and the morphology of its facial facet is highly variable when compared to other mammals. In this study, we quantify the species‐specific variability in size and shape of the lacrimal facial facet in species of Cervidae (deer) and relate it to systematics and various aspects of their ecology and behavior. We sampled 143 skull specimens from 10 genera; 12 Moschus and 3 Tragulus specimens were used as outgroups. We find that size and shape of the lacrimal facial facet allow differentiating most species analyzed here, except for Mazama gouazoubira and Capreolus capreolus. Size and shape of the lacrimal facial facet vary widely across Cervidae regardless of their systematic relationships, ecology or behavior. Thus, we could not detect a unique signature of adaptational criteria in lacrimal morphology. Our data indicate that the lacrimal facial facet scales allometrically with skull size, in particular, the lacrimojugal length scales positively and the lacrimomaxillar length scales negatively. However, correlation analyses did not reveal any differences in the integration of the lacrimal bone with any specific skull module in any of the species compared. Lastly, we could not ascertain any correlation between the size and position of the preorbital depression with the size and shape of the lacrimal facial facet. We conclude that the lacrimal facial facet is highly flexible and may rapidly adjust to its surrounding bones. Its allometric growth appears to be an example of exaptation: changes in size and shape in the context of the increase of the skull length provide lacrimal contacts, in particular, a lacrimojugal one, which may serve to reduce mechanical loads resulting from increasingly larger antlers in large cervids.
Effects of sound therapy on resting‐state functional brain networks in patients with tinnitus: A graph‐theoretical‐based study
Authors: Han Lv , Yawen Liu , Hao Wang , Chunli Liu , Pengfei Zhao , Zhengyu Zhang , Zhaodi Wang , Zhenghan Yang , Shusheng Gong , Zhenchang Wang 
Published: May 2019

BackgroundTinnitus is considered to be triggered by aberrant neural activity in the brain. Sound therapy is regarded as a reasonable management option for tinnitus treatment and has been applied in the clinical setting for decades.HypothesisWe hypothesized that sound therapy, a commonly used tinnitus treatment method, would alter the functional connectivity (FC) of brain regions in tinnitus models.Study TypeLongitudinal.PopulationResting‐state functional MRI data were collected from 27 tinnitus patients before and after 12 weeks of sound therapy. Twenty‐seven age‐ and sex‐matched healthy controls were also longitudinally scanned at the 12‐week timepoint.Field Strength3.0T MRI system and echo planar imaging (EPI) sequence, 3D brain volume imaging (BRAVO) sequence.AssessmentFunctional connectivity strength (FCS), a graph‐theoretical‐based analytic method, was applied to analyze the FC features in the whole brain.Statistical TestsStudent's t‐test and chi‐square test were used for analyses between two groups. A two‐way analysis of covariance (ANCOVA) followed by post‐hoc analyses was performed to determine differences of FC.ResultsThe interaction effect between the two groups and two scans on FCS was observed in the bilateral thalami and left anterior cingulate cortex (ACC). The fitted FCS values in the bilateral thalami were significantly higher in tinnitus patients at baseline and decreased to a relatively normal range after sound therapy compared with healthy controls. Conversely, the fitted FCS values in the left ACC were within the normal range, but increased after treatment (1.08 ± 0.29, P < 0.02); however, there was no change in the control group. Importantly, significant correlations were observed between the FCS changes in the right thalamus (P = 0.028), the FC of the right thalamus‐right inferior frontal gyrus (P = 0.015), and symptomatic improvement.Data ConclusionSound therapy may modulate the brain network by altering the gating function of the thalamus as well as enhancing the tinnitus‐canceling system.Level of Evidence: 2Technical Efficacy Stage: 4 J. Magn. Reson. Imaging 2019;50:1731–1741.
Synthesis and Aggregation Behavior of Trisiloxane Ionic Liquids in Aqueous Solution
Authors: Tan Jinglin , Xiong Xiaomei , Yan Ping 
Published: May 2019

AbstractTrisiloxane ionic liquids with polyether groups (Si3pyCl‐EO3) were synthesized via thiol‐ene reaction between 1‐methyl‐1‐[bis(vinyldimethylsiloxy)methyl]silylpropylpyrrolidinium chloride (Vi‐Si3pyCl) and tri(ethylene glycol) methyl ether thiol. The aggregation behavior of the trisiloxane ionic liquids, Si3pyCl‐EO3 and Vi‐Si3pyCl, in aqueous solution was investigated using surface tension, electrical conductivity, dynamic light scattering, and transmission electron microscopy. The structures of trisiloxane ionic liquids can obviously influence their aggregation behavior. Vi‐Si3pyCl has excellent surface activity (22.3 mN m−1). However, Si3pyCl‐EO3 can only reduce the surface tension of water to 33.5 mN m−1. In comparison with Vi‐Si3PyCl, Si3PyCl‐EO3 has a bulkier hydrophobic group and a higher Αmin value (127.8 Å2) caused by the introduction of the tri(ethylene glycol) methyl ether groups by thiol‐ene reaction. The micellization of Vi‐Si3PyCl is entropy driven, while the aggregation process of Si3PyCl‐EO3 in aqueous solution is enthalpy driven.
Annulus fibrosus cell sheets limit disc degeneration in a rat annulus fibrosus injury model
Authors: Nukaga Tadashi , Sakai Daisuke , Schol Jordy , Sato Masato , Watanabe Masahiko 
Published: May 2019

AbstractIn recent years, studies have explored novel approaches for cell transplantation to enable annulus fibrosus (AF) regeneration of the intervertebral disc in particular for lumbar disc herniation. Nevertheless, successful engraftment of cells is structurally challenging, and no definitive method has yet been established. This study investigated the potential of cell sheet technology to facilitate cell engraftment for AF repair. AF injury was induced by a 1 × 1 mm defect in rat tails after which AF cell sheets were transplanted. Its regenerative effects were compared to a nondegenerated and degeneration only conditions. Degenerative changes of the entire intervertebral disc were examined by disc height measurements, histology, and immunohistochemistry for 4‐, 8‐, and 12‐weeks post‐transplantation. Cell engraftment was confirmed by tracing PKH26 fluorescent dyed AF cells. In the transplant group, disc degeneration was significantly suppressed after 4, 8, and 12 weeks when compared with the degenerative group, as indicated by histological scoring and DHI observations. At 2 and 4 weeks after transplant, PKH26 positive cells could be detected in defect region and surrounding AF. The results suggest cell engraftment into AF tissue could be established by the cell sheet technology without additional scaffolding or adhesives. In short, AF cell sheets appear to be an effective and accessible tool for AF repair and to support intervertebral disc regeneration.
Signalling effects on symbolic status and travellers' well‐being in the luxury cruise industry
Authors: Loureiro Sandra Maria Correia , Japutra Arnold , Kwun David 
Published: May 2019

AbstractThe purpose of this research is to examine the role of signalling effects of reputation and credibility on luxury cruise travellers' well‐being and the mediating role of symbolic status (i.e., prestige and authentic pride). This study also explores the moderation effects of socio‐economic status and past experiences. The results demonstrate noteworthy effects of reputation on prestige, authentic pride, and, subsequently, on travellers' well‐being. The results also reveal the moderating role of socio‐economic status between authentic pride and well‐being. In addition, the results find significant differences between low‐ and high‐experience groups in three relationships: reputation and prestige, credibility and prestige, and reputation and authentic pride.
Correlation of quantitative conductivity mapping and total tissue sodium concentration at 3T/4T
Authors: Liao Yupeng , Lechea Nazim , Magill Arthur W. , Worthoff Wieland A. , Gras Vincent , Shah N. Jon 
Published: May 2019

PurposeTo investigate the correlation between electrical conductivity and sodium concentration, both measured in vivo, in the human brain.MethodsConductivity measurements were performed on samples with different sodium (Na+) and agarose concentrations using a dielectric probe, and the correlation between conductivity and Na+ content was evaluated. Subsequently, brain conductivity and total Na+ content maps were measured in 8 healthy subjects using phase‐based MREPT and sodium MRI, respectively. After co‐registration and spatial normalization to the 1 mm 152 MNI brain atlas, the relationship between conductivity and tissue sodium concentration (TSC) was examined within different brain regions.ResultsThe conductivities of agarose gels increased linearly with NaCl concentration, while remaining almost independent of agarose content. When measured in healthy subjects, conductivities showed positive correlation with total tissue sodium concentration (R = 0.39, P < 0.005). The same trend was found in gray matter (R = 0.36, P < 0.005) and in white matter (R = 0.28, P < 0.05).ConclusionTissue conductivity shows a positive correlation with total sodium concentration. Conductivity might serve as a novel technique to visualize the total tissue electrolyte concentration, although refinements in the consideration of e.g., tissue water content, would be necessary to improve the quantitative value.
Development of an algorithm to identify inpatient opioid‐related overdoses and oversedation using electronic data
Authors: Green Carla A. , Hazlehurst Brian , Brandes John , Sapp Daniel S. , Janoff Shannon L. , Coplan Paul M. , DeVeaugh‐Geiss Angela 
Published: May 2019

AbstractPurposeTo facilitate surveillance and evaluate interventions addressing opioid‐related overdoses, algorithms are needed for use in large health care databases to identify and differentiate community‐occurring opioid‐related overdoses from inpatient‐occurring opioid‐related overdose/oversedation.MethodsData were from Kaiser Permanente Northwest (KPNW), a large integrated health plan. We iteratively developed and evaluated an algorithm for electronically identifying inpatient overdose/oversedation in KPNW hospitals from 1 January 2008 to 31 December 2014. Chart audits assessed accuracy; data sources included administrative and clinical records.ResultsThe best‐performing algorithm used these rules: (1) Include events with opioids administered in an inpatient setting (including emergency department/urgent care) followed by naloxone administration within 275 hours of continuous inpatient stay; (2) exclude events with electroconvulsive therapy procedure codes; and (3) exclude events in which an opioid was administered prior to hospital discharge and followed by readmission with subsequent naloxone administration. Using this algorithm, we identified 870 suspect inpatient overdose/oversedation events and chart audited a random sample of 235. Of the random sample, 185 (78.7%) were deemed overdoses/oversedation, 37 (15.5%) were not, and 13 (5.5%) were possible cases. The number of hours between time of opioid and naloxone administration did not affect algorithm accuracy. When “possible” overdoses/oversedations were included with confirmed events, overall positive predictive value (PPV) was very good (PPV = 84.0%). Additionally, PPV was reasonable when evaluated specifically for hospital stays with emergency/urgent care admissions (PPV = 77.0%) and excellent for elective surgery admissions (PPV = 97.0%).ConclusionsAlgorithm performance was reasonable for identifying inpatient overdose/oversedation with best performance among elective surgery patients.
Emergent Upconversion Sustainable Micro‐Optical Trapping Device
Authors: Lin Kuan Bo , Shen Ting Wei , Su Yen Hsun 
Published: May 2019

AbstractUltrathin‐thickness single‐junction Si‐based solar cells can be developed to enhance photoelectric conversion efficiency (PECE) approaching to Shockley–Queisser limit. However, loss of short circuit current is a crucial factor that dramatically affects PECE improvement. Even though many studies have focused on rare reflector architecture for facilitating near‐infrared radiation absorption, PECE is still constraint due to its fabrication cost. Herein, an upconversion sustainable micro‐optical trapping device is reported. Using a systematic procedure, a high upconversion performance core–shell‐nanoparticles (CSNPs) structure is synthesized. Accordingly, silica diatom microporous frustule is a good electromagnetic field localization chamber, upon which CSNPs are embedded through a microassemble synthesis. This emerging device can be support on ultrathin‐thickness single‐junction Si‐based solar cells as a rare absorber with its low preparation cost. In the experiment, CSNPs upconversion optical density by surface plasmon resonance of Au nanoparticle's enhancement can be increased five‐time greater than NaYF4 without SiO2 coating. A finite difference time domain simulation and real color luminescence images in this study are also demonstrated.
Chimeric dihydrofolate reductases display properties of modularity and biophysical diversity
Authors: Rodrigues João V. , Ogbunugafor C. Brandon , Hartl Daniel L. , Shakhnovich Eugene I. 
Published: May 2019

AbstractWhile reverse genetics and functional genomics have long affirmed the role of individual mutations in determining protein function, there have been fewer studies addressing how large‐scale changes in protein sequences, such as in entire modular segments, influence protein function and evolution. Given how recombination can reassort protein sequences, these types of changes may play an underappreciated role in how novel protein functions evolve in nature. Such studies could aid our understanding of whether certain organismal phenotypes related to protein function—such as growth in the presence or absence of an antibiotic—are robust with respect to the identity of certain modular segments. In this study, we combine molecular genetics with biochemical and biophysical methods to gain a better understanding of protein modularity in dihydrofolate reductase (DHFR), an enzyme target of antibiotics also widely used as a model for protein evolution. We replace an integral α‐helical segment of Escherichia coli DHFR with segments from a number of different organisms (many nonmicrobial) and examine how these chimeric enzymes affect organismal phenotypes (e.g., resistance to an antibiotic) as well as biophysical properties of the enzyme (e.g., thermostability). We find that organismal phenotypes and enzyme properties are highly sensitive to the identity of DHFR modules, and that this chimeric approach can create enzymes with diverse biophysical characteristics.
Cross‐Lagged Relations Among Linguistic Skills in European Portuguese: A Longitudinal Study
Authors: Santos Sandra , Cadime Irene , Viana Fernanda Leopoldina , Ribeiro Iolanda 
Published: May 2019

AbstractResearch has widely demonstrated the contribution of word reading, listening comprehension skills, and oral reading fluency to reading comprehension performance. However, the existence of reciprocal relations among these skills has been investigated less frequently. The authors examined the directionality of the relations among reading comprehension, listening comprehension, word reading, and oral reading fluency in Portuguese elementary school students from second to fourth grade by using a longitudinal cross‐lagged design. The sample was composed of 261 students assessed at the end of grades 2, 3, and 4. The results indicated that there is a reciprocal relation between listening comprehension and reading comprehension in every grade and that oral reading fluency and reading comprehension have a reciprocal relation only in the initial years of schooling, similar to the observed relation between oral reading fluency and word reading. The results are discussed considering their potential impact and the limitations of the study.
3D Interdigitated Microsupercapacitors with Record Areal Cell Capacitance
Authors: Ferris Anaïs , Bourrier David , Garbarino Sébastien , Guay Daniel , Pech David 
Published: May 2019

AbstractDue to their high‐power density and long lifetime, microsupercapacitors have been considered as an efficient energy supply/storage solution for the operation of small electronic devices. However, their fabrication remains confined to 2D thin‐film microdevices with limited areal energy. In this study, the integration of all‐solid‐state 3D interdigitated microsupercapacitors on 4 in. silicon wafers with record energy density is demonstrated. The device electrodes are composed of a pseudocapacitive hydrated ruthenium dioxide RuO2 deposited onto highly porous current collectors. The encapsulated devices exhibit cell capacitance of 812 mF cm−2 per footprint area at an energy density of 329 mJ cm−2, which is the highest value ever reported for planar configuration. These components achieve one of the highest surface energy/power density trade‐offs and address the issue of electrical energy storage of modern electronics.
Bone Defect Model Dependent Optimal Pore Sizes of 3D‐Plotted Beta‐Tricalcium Phosphate Scaffolds for Bone Regeneration
Authors: Diao Jingjing , Ding Huanwen , Huang Minqiang , Fu Xiaoling , Zou Fen , Li Tianjie , Zhao Naru , Mao Chuanbin , Wang Yingjun 
Published: May 2019

AbstractBones such as long bone and flat bone vary physiologically and anatomically. How pore sizes affect bone regeneration in different bone defects and its mechanisms are not well studied. Herein, typical long bone (tibia) defect model and flat bone (calvarial) defect model are applied to investigate their bone regeneration capacity and the underlying mechanism mediated by the pore sizes. Pore sizes (100, 250, and 400 µm) of the beta‐tricalcium phosphate (β‐TCP) scaffolds are strictly controlled utilizing a 3D plotting method. Bone regeneration capability in vivo by these pore sizes is related to the defect models (tibial defects and calvarial defects). Among the three pore sizes being studied, 100 µm pore size is most efficient in inducing bone formation in repairing flat bone defects, which is owing to the enhanced osteoblast differentiation in the intramembranous ossification. Differently, the scaffolds with a pore size of 400 µm display the best ability of bone formation for repairing long bone defects, which is speculated to be related to the accelerated formation of cartilage templates and ossification centers in endochondral ossification. This study suggests that bone defect type should be concerned in the design of the porous structure of an artificial material.
Decoupling from Moral Responsibility for CSR: Employees' Visionary Procrastination at a SME
Authors: Sendlhofer Tina 
Published: May 2019

Abstract
Most studies of corporate social responsibility (CSR) have focused on the organisational level, while the individual level of analysis has been treated as a ‘black box’ when researching antecedents of CSR engagement or disengagement. This article offers insights into a small and medium-sized enterprise (SME) that is recognised as a pioneer in CSR. Although the extant literature suggests that the owner-manager is crucial in the implementation of CSR, this study reveals that employees drive CSR. The employees in the focal firm voluntarily joined forces based on their shared perception of moral responsibility for CSR and they developed strict targets to be achieved by 2030. Despite their strong ethical and moral perspective when enacting CSR, they disengaged from their moral responsibility for CSR in various contexts. This paper contributes to the theory of moral decoupling by uncovering a novel context of disengagement—‘visionary procrastination’. Visionary procrastination is suggested to be a particularly relevant context of disengagement when individuals perceive moral responsibility for CSR. Moreover, by delivering insights into the antecedents of employee-initiated CSR on the organisational level, this study adds to the growing body of literature on the micro-foundations of CSR.
Computational enactivism under the free energy principle
Authors: Korbak Tomasz 
Published: May 2019

AbstractIn this paper, I argue that enactivism and computationalism—two seemingly incompatible research traditions in modern cognitive science—can be fruitfully reconciled under the framework of the free energy principle (FEP). FEP holds that cognitive systems encode generative models of their niches and cognition can be understood in terms of minimizing the free energy of these models. There are two philosophical interpretations of this picture. A computationalist will argue that as FEP claims that Bayesian inference underpins both perception and action, it entails a concept of cognition as a computational process. An enactivist, on the other hand, will point out that FEP explains cognitive systems as constantly self-organizing to non-equilibrium steady-state. My claim is that these two interpretations are both true at the same time and that they enlighten each other.