bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Participation in the Daily Lives of Frail Older Adults: Types of Participation and Influencing Factors
Authors: Duppen Daan , Lambotte Deborah , Dury Sarah , Smetcoren An-Sofie , Pan Honghui , De Donder Liesbeth ,   D-SCOPE Consortium, Smetcoren A- S , Dury S , De Donder L , De Witte N , Dierckx E , Lambotte D , Fret B , Duppen D , Kardol M , Verté D , Hoeyberghs L , De Witte N , De Roeck E , Engelborghs S , Dedeyn P P , Van der Elst M C J , De Lepeleire J , Schoenmakers B , van der Vorst A , Zijlstra G A R , Kempen G I J M , Schols J M G A , Smetcoren A- S , Dury S , De Donder L , De Witte N , Dierckx E , Lambotte D , Fret B , Duppen D , Kardol M , Verté D , Hoeyberghs L , De Witte N , De Roeck E , Engelborghs S , Dedeyn P P , Van der Elst M C J , De Lepeleire J , Schoenmakers B , van der Vorst A , Zijlstra G A R , Kempen G I J M , Schols J M G A 
Published: April 2019

Abstract

Objectives
The advantages of social participation for older adults are well established and have been adopted in aging policy frameworks. However, little is known about the social participation of frail older adults. This research examined the types of social interaction of very frail older adults and the factors influencing this participation.

Method
Interviews with 38 very frail older adults were analyzed using Levasseur and colleagues’ (Levasseur, Richard, Gauvin, & Raymond (2010). Inventory and analysis of definitions of social participation found in the aging literature: Proposed taxonomy of social activities. Social Science and Medicine (1982), 71, 2141–2149) taxonomy activity levels of involvement with others. A qualitative hybrid approach with inductive and deductive thematic analyses was used.

Results
Participants often disengaged from activities with high involvement with others, preferring activities with less involvement. Low-key participation emerged as an important type of social participation enabling frail older adults to remain engaged in society. Key factors that influenced social participation were functional decline, and the physical (e.g., traffic, the disappearance of local stores) and social environment (e.g., social networks and the presence of meeting places such as community centers).

Discussion
Findings advance our knowledge and recognition of the different ways frail older adults participate in society. Despite their frailty, older adults wish to stay socially active. Focusing on the social environment in the frameworks and policies of Age-Friendly Cities and Communities will benefit these individuals.
Risk of suicide attempt associated with isotretinoin: a nationwide cohort and nested case-time-control study
Authors: Droitcourt Catherine , Nowak Emmanuel , Rault Caroline , Happe André , Le Nautout Béranger , Kerbrat Sandrine , Balusson Frédéric , Poizeau Florence , Travers David , Sapori Jean-Marc , Lagarde Emmanuel , Rey Grégoire , Guillot Bernard , Oger Emmanuel , Dupuy Alain 
Published: April 2019

Abstract

Background
Isotretinoin is the only effective treatment for severe acne. An isotretinoin-related suicide risk is still debated and under scrutiny by regulatory agencies. Our objectives were: to assess the risk of suicide attempt before, during and after isotretinoin treatment; to detect any potential triggering effect of isotretinoin initiation on suicide attempt.

Methods
We implemented a cohort and nested case-time-control study of subjects treated with oral isotretinoin (course or initiation) aged 10–50 years, using the Nationwide French Health Insurance data (2009–2016). The main outcome was hospitalized suicide attempt. Standardized incidence ratios for hospitalized suicide attempts were calculated before, during and after isotretinoin treatment. The number of isotretinoin initiations was compared in risk and control periods of 2 months using a case-time-control analysis.

Results
In all, 443 814 patients (median age 20.0 years; interquartile range 17.0–27.0 years) were exposed to isotretinoin, amounting to 244 154 person-years, with a marked seasonality for treatment initiation. Compared with the French general population, the occurrence of suicide attempts under isotretinoin treatment was markedly lower, with a standardized incidence ratio of 0.6 [95% confidence interval (CI) = 0.53–0.67]; the same applied, to a lesser extent, before and after isotretinoin treatment. In the case-time-control analysis, among cases of suicide attempt, 108 and 127 isotretinoin initiations were observed in the risk and control periods respectively (i.e. 0–2 months and 2–4 months before the date of suicide attempt). The comparison with the 1199 and 1253 initiations observed among matched controls in the same two periods yielded a case-time-control odds ratio of 0.89 (95% CI = 0.68–1.16). A sensitivity analysis using three-month periods and a complementary analysis adding completed suicides for case definition showed consistent results.

Conclusion
Compared with the general population, a lower risk of suicide attempt was observed among patients exposed to isotretinoin and there was no evidence for a triggering effect of isotretinoin initiation on suicide attempt. A selection of patients at lower risk for suicidal behaviour and appropriate treatment management could explain these findings. Risk management plans should therefore be maintained.
Ceftazidime-Avibactam in Combination With Fosfomycin: A Novel Therapeutic Strategy Against Multidrug-Resistant Pseudomonas aeruginosa
Authors: Papp-Wallace Krisztina M , Zeiser Elise T , Becka Scott A , Park Steven , Wilson Brigid M , Winkler Marisa L , D’Souza Roshan , Singh Indresh , Sutton Granger , Fouts Derrick E , Chen Liang , Kreiswirth Barry N , Ellis-Grosse Evelyn J , Drusano George L , Perlin David S , Bonomo Robert A 
Published: April 2019

Abstract
Previously, by targeting penicillin-binding protein 3, Pseudomonas-derived cephalosporinase (PDC), and MurA with ceftazidime-avibactam-fosfomycin, antimicrobial susceptibility was restored among multidrug-resistant (MDR) Pseudomonas aeruginosa. Herein, ceftazidime-avibactam-fosfomycin combination therapy against MDR P. aeruginosa clinical isolate CL232 was further evaluated. Checkerboard susceptibility analysis revealed synergy between ceftazidime-avibactam and fosfomycin. Accordingly, the resistance elements present and expressed in P. aeruginosa were analyzed using whole-genome sequencing and transcriptome profiling. Mutations in genes that are known to contribute to β-lactam resistance were identified. Moreover, expression of blaPDC, the mexAB-oprM efflux pump, and murA were upregulated. When fosfomycin was administered alone, the frequency of mutations conferring resistance was high; however, coadministration of fosfomycin with ceftazidime-avibactam yielded a lower frequency of resistance mutations. In a murine infection model using a high bacterial burden, ceftazidime-avibactam-fosfomycin significantly reduced the P. aeruginosa colony-forming units (CFUs), by approximately 2 and 5 logs, compared with stasis and in the vehicle-treated control, respectively. Administration of ceftazidime-avibactam and fosfomycin separately significantly increased CFUs, by approximately 3 logs and 1 log, respectively, compared with the number at stasis, and only reduced CFUs by approximately 1 log and 2 logs, respectively, compared with the number in the vehicle-treated control. Thus, the combination of ceftazidime-avibactam-fosfomycin was superior to either drug alone. By employing a "mechanism-based approach" to combination chemotherapy, we show that ceftazidime-avibactam-fosfomycin has the potential to offer infected patients with high bacterial burdens a therapeutic hope against infection with MDR P. aeruginosa that lack metallo-β-lactamases.
The Contribution of Kaposi’s Sarcoma–Associated Herpesvirus to Mortality in Hospitalized Human Immunodeficiency Virus–Infected Patients Being Investigated for Tuberculosis in South Africa
Authors: Blumenthal Melissa J , Schutz Charlotte , Barr David , Locketz Michael , Marshall Vickie , Whitby Denise , Katz Arieh A , Uldrick Thomas , Meintjes Graeme , Schäfer Georgia 
Published: April 2019

AbstractBackgroundDespite increasing numbers of human immunodeficiency virus (HIV)–infected South Africans receiving antiretroviral therapy (ART), tuberculosis (TB) remains the leading cause of mortality. Approximately 25% of patients treated for TB have microbiologically unconfirmed diagnoses. We assessed whether elevated Kaposi’s sarcoma–associated herpesvirus (KSHV) viral load (VL) contributes to mortality in hospitalized HIV-infected patients investigated for TB.MethodsSix hundred eighty-two HIV-infected patients admitted to Khayelitsha Hospital, South Africa, were recruited, investigated for TB, and followed for 12 weeks. KSHV serostatus, peripheral blood KSHV-VL, and KSHV-associated clinical correlates were evaluated.ResultsMedian CD4 count was 62 (range, 0–526) cells/μL; KSHV seropositivity was 30.7% (95% confidence interval [CI], 27%–34%); 5.8% had detectable KSHV-VL (median, 199.1 [range, 13.4–2.2 × 106] copies/106 cells); 22% died. Elevated KSHV-VL was associated with mortality (adjusted odds ratio, 6.5 [95% CI, 1.3–32.4]) in patients without TB or other microbiologically confirmed coinfections (n = 159). Six patients had “possible KSHV-inflammatory cytokine syndrome” (KICS): 5 died, representing significantly worse survival (P &lt; .0001), and 1 patient was diagnosed with KSHV-associated multicentric Castleman disease at autopsy.ConclusionsGiven the association of mortality with elevated KSHV-VL in critically ill HIV-infected patients with suspected but not microbiologically confirmed TB, KSHV-VL and KICS criteria may guide diagnostic and therapeutic evaluation.
The Complexity of Multilateral Negotiations: Problem or Opportunity? A Qualitative Study of Five Simulations with Mexican Students
Authors: Meschoulam Mauricio , Muhech Andrea , Naanous Tania , Quintanilla Sofía , Aguilar Renata , Ochoa Jorge , Rodas Cristobal 
Published: April 2019

AbstractEducation in International Relations requires continual evolution. One approach is the use of negotiation simulations for complex issues. Despite the extensive literature on the subject, there is a lack of qualitative research on this approach, particularly in Latin America and Mexico. This paper presents the findings of a qualitative research on five simulations with Mexican students. The five exercises were characterized by the application of elements that are not usually included in traditional simulations, such as a multiweek phase of prior negotiations, the use of Twitter, the introduction of nonstate actors, a gala dinner, and a continuous feed of real world news. We investigated 118 participants through 30 in depth interviews analyzed with NVivo, a systematized analysis of 118 reports, documents and tweets, and a pre-post questionnaire applied to the fifth group. The results in the five simulations were highly positive. The students reported a greater awareness of the complexity of international negotiations. Such awareness can present both a risk and an opportunity: a risk because those circumstances caused discouragement and frustration in many participants, and an opportunity because those same circumstances, properly channeled, triggered parallel skills, and creative thinking. Therefore, the role of the facilitation team was fundamental.
Heparin-Induced Fever: A Case Report and Literature Review
Authors: Laun Jake , Laun Katie , Farooqi Adeel , Smith David J 
Published: April 2019

Abstract
Burn patients are often plagued by fever due to the inflammatory nature of their injuries as well as the normal postoperative systemic inflammatory response syndrome. One etiology for fever, often not initially considered, is drug-induced fever. A rare cause of drug-induced fever is heparin with only one documented case reported in the literature. We present a case of heparin-induced fever in a patient who experienced a 32% total BSA friction burn after a motorcycle crash.
Spatial and Temporal Dynamics of the Native Banana-Spotting Bug, Amblypelta lutescens lutescens (Hemiptera: Coreidae), in Avocado Crops in North Queensland, Australia
Authors: Lindsay Karel R , Zalucki Myron P , Newton Ian R , Furlong Michael J 
Published: April 2019

Abstract
The native banana-spotting bug, Amblypelta lutescens lutescens Distant, is a major polyphagous insect pest of many tropical and subtropical horticultural crops in Australia, including high-valued commodities such as avocado (Persea americana Mill. (Laurales: lauraceae)). The cryptic nature of A. l. lutescens makes it difficult to sample, and much about its ecology and behavior remains poorly understood. A lure based on the main components of the semiochemicals emitted by male A. l. lutescens, which is attractive to adult males, adult females, and nymphs, has been developed and incorporated into a trap, facilitating sampling of A. l. lutescens in the field. A 2-yr study investigated the spatial and temporal dynamics of the pest in two conventionally managed avocado (cv. Shepard) orchards using a grid (36 m × 36 m) of traps across each. In each year of the study, higher numbers of A. l. lutescens were recorded from October to June. In one field, spatial clustering of adults was detected in close proximity to an adjacent lime [Citrus aurantiifolia (Christm.) (Rutales: rutaceae) Swingle] crop that was not managed with insecticides during the study. Spatial clustering of nymphs was detected adjacent to native riparian vegetation in the other field. The results suggest that source populations of A. l. lutescens could originate from neighboring crops that host A. l. lutescens and from riparian vegetation. Focused sampling of trees at the interface with these vegetation types could lead to early pest detection, timely suppression, and therefore improved pest management.
US Bias in the Study of Asian Security: Using Europe to Study Asia
Authors: Kang David C , Lin Alex Yu-Ting 
Published: April 2019

AbstractScholars have been particularly hampered in their explanations and understanding of Asian security because they often learn little about Asia in their graduate training. The international relations (IR) literature draws an overwhelming proportion of its empirical source material from the European historical experience. We show that the curricula and training that graduate students of international relations receive in the United States are overwhelmingly focused on European examples. In short, the median American scholar of IR is deeply comfortable with European examples and analogies and has almost no exposure to Asian examples and history. Thus, when faced with Asian examples, they are considered within the context they are taught: through the European lens. We conclude with a call for greater attention to the empirical reality that is Asia.
Destruction and multiple ionization of PAHs by X-rays in circumnuclear regions of AGNs
Authors: Monfredini Thiago , Quitián-Lara Heidy M , Fantuzzi Felipe , Wolff Wania , Mendoza Edgar , Lago Alexsandre F , Sales Dinalva A , Pastoriza Miriani G , Boechat-Roberty Heloisa M 
Published: April 2019

ABSTRACT
The infrared signatures of polycyclic aromatic hydrocarbons (PAHs) are observed in a variety of astrophysical objects, including the circumnuclear medium of active galactic nuclei (AGNs). These are sources of highly energetic photons (0.2–10 keV), exposing the PAHs to a harsh environment. In this work, we examined experimentally the photoionization and photostability of naphthalene (C10H8), anthracene (C14H10), 2-methyl-anthracene (C14H9CH3), and pyrene (C16H10) upon interaction with photons of 275, 310, and 2500 eV. The measurements were performed at the Brazilian Synchrotron Light Laboratory using time-of-flight mass-spectrometry. We determined the absolute photoionization and photodissociation cross-sections as a function of the incident photon energy; the production rates of singly, doubly, and triply charged ions; and the molecular half-lives in regions surrounding AGNs. Even considering moderate X-ray optical depth values (τ = 4.45) due to attenuation by the dusty torus, the half-lives are not long enough to account for PAH detection. Our results suggest that a more sophisticated interplay between PAHs and dust grains should be present in order to circumvent molecular destruction. We could not see any significant difference in the half-life values by increasing the size of the PAH carbon backbone, NC, from 10 to 16. However, we show that the multiple photoionization rates are significantly greater than the single ones, irrespective of the AGN source. We suggest that an enrichment of multiply charged ions caused by X-rays can occur in AGNs.
Can we quickly flag ultra-long gamma-ray bursts?
Authors: Gendre B , Joyce Q T , Orange N B , Stratta G , Atteia J L , Boër M 
Published: April 2019

Abstract
Ultra-long gamma-ray bursts are a class of high-energy transients lasting several hours. Their exact nature is still elusive, and several models have been proposed to explain them. Because of the limited coverage of wide-field gamma-ray detectors, the study of their prompt phase with sensitive narrow-field X-ray instruments could help in understanding the origin of ultra-long GRBs. However, the observers face a true problem in rapidly activating follow-up observations, due to the challenging identification of an ultra-long GRB before the end of the prompt phase. We present here a comparison of the prompt properties available after a few tens of minutes of a sample of ultra-long GRBs and normal long GRBs, looking for prior indicators of the long duration. We find that there is no such clear prior indicator of the duration of the burst. We also found that statistically, a burst lasting at least 10 and 20 minutes has respectively $28{{\ \rm per\ cent}}$ and $50{{\ \rm per\ cent}}$ probability to be an ultralong event. These findings point towards a common central engine for normal long and ultra-long GRBs, with the collapsar model privileged.
On the dynamics and survival of fractal clouds in galactic winds
Authors: Banda-Barragán W E , Zertuche F J , Federrath C , García Del Valle J , Brüggen M , Wagner A Y 
Published: April 2019

Abstract
Recent observations suggest that dense gas clouds can survive even in hot galactic winds. Here we show that the inclusion of turbulent densities with different statistical properties has significant effects on the evolution of wind-swept clouds. We investigate how the initial standard deviation of the lognormal density field influences the dynamics of quasi-isothermal clouds embedded in supersonic winds. We compare uniform, fractal solenoidal, and fractal compressive cloud models in both 3D and 2D hydrodynamical simulations. We find that the processes of cloud disruption and dense gas entrainment are functions of the initial density distribution in the cloud. Fractal clouds accelerate, mix, and are disrupted earlier than uniform clouds. Within the fractal cloud sample, compressive clouds retain high-density nuclei, so they are more confined, less accelerated, and have lower velocity dispersions than their solenoidal counterparts. Compressive clouds are also less prone to Kelvin–Helmholtz and Rayleigh–Taylor instabilities, so they survive longer than solenoidal clouds. By comparing the cloud properties at the destruction time, we find that dense gas entrainment is more effective in uniform clouds than in either of the fractal clouds, and it is more effective in solenoidal than in compressive models. In contrast, mass loading into the wind is more efficient in compressive cloud models than in uniform or solenoidal models. Overall, wide density distributions lead to inefficient entrainment, but they facilitate mass loading and favour the survival of very dense gas in hot galactic winds.
Horizon-AGN virtual observatory – 1. SED-fitting performance and forecasts for future imaging surveys
Authors: Laigle C , Davidzon I , Ilbert O , Devriendt J , Kashino D , Pichon C , Capak P , Arnouts S , de la Torre S , Dubois Y , Gozaliasl G , Le Borgne D , Lilly S , McCracken H J , Salvato M , Slyz A 
Published: April 2019

Abstract
Using the light-cone from the cosmological hydrodynamical simulation horizon-AGN, we produced a photometric catalogue over 0 &lt; z &lt; 4 with apparent magnitudes in COSMOS, Dark Energy Survey, Large Synoptic Survey Telescope (LSST)-like, and Euclid-like filters at depths comparable to these surveys. The virtual photometry accounts for the complex star formation history (SFH) and metal enrichment of horizon-AGN galaxies, and consistently includes magnitude errors, dust attenuation, and absorption by intergalactic medium. The COSMOS-like photometry is fitted in the same configuration as the COSMOS2015 catalogue. We then quantify random and systematic errors of photometric redshifts, stellar masses, and star formation rates (SFR). Photometric redshifts and redshift errors capture the same dependencies on magnitude and redshift as found in COSMOS2015, excluding the impact of source extraction. COSMOS-like stellar masses are well recovered with a dispersion typically lower than 0.1 dex. The simple SFHs and metallicities of the templates induce a systematic underestimation of stellar masses at z &lt; 1.5 by at most 0.12 dex. SFR estimates exhibit a dust-induced bimodality combined with a larger scatter (typically between 0.2 and 0.6 dex). We also use our mock catalogue to predict photometric redshifts and stellar masses in future imaging surveys. We stress that adding Euclid near-infrared photometry to the LSST-like baseline improves redshift accuracy especially at the faint end and decreases the outlier fraction by a factor ∼2. It also considerably improves stellar masses, reducing the scatter up to a factor 3. It would therefore be mutually beneficial for LSST and Euclid to work in synergy.
Automated distant galaxy merger classifications from Space Telescope images using the Illustris simulation
Authors: Snyder Gregory F , Rodriguez-Gomez Vicente , Lotz Jennifer M , Torrey Paul , Quirk Amanda C N , Hernquist Lars , Vogelsberger Mark , Freeman Peter E 
Published: April 2019

ABSTRACT
We present image-based evolution of galaxy mergers from the Illustris cosmological simulation at 12 time-steps over 0.5 &lt; z &lt; 5. To do so, we created approximately one million synthetic deep Hubble Space Telescope and James Webb Space Telescope images and measured common morphological indicators. Using the merger tree, we assess methods to observationally select mergers with stellar mass ratios as low as 10:1 completing within ±250 Myr of the mock observation. We confirm that common one- or two-dimensional statistics select mergers so defined with low purity and completeness, leading to high statistical errors. As an alternative, we train redshift-dependent random forests (RFs) based on 5–10 inputs. Cross-validation shows the RFs yield superior, yet still imperfect, measurements of the late-stage merger fraction, and they select more mergers in bulge-dominated galaxies. When applied to CANDELS morphology catalogues, the RFs estimate a merger rate increasing to at least z = 3, albeit two times higher than expected by theory. This suggests possible mismatches in the feedback-determined morphologies, but affirms the basic understanding of galaxy merger evolution. The RFs achieve completeness of roughly $70{{\ \rm per\ cent}}$ at 0.5 &lt; z &lt; 3, and purity increasing from $10{{\ \rm per\ cent}}$ at z = 0.5–60 per cent at z = 3. At earlier times, the training sets are insufficient, motivating larger simulations and smaller time sampling. By blending large surveys and large simulations, such machine learning techniques offer a promising opportunity to teach us the strengths and weaknesses of inferences about galaxy evolution.