bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Benzaldehyde and Benzopyran Compounds from the Endophytic Fungus Paraphaeosphaeria sp. F03 and Their Antimicrobial and Cytotoxic Activities
Authors: de Amorim Marcelo R. , Hilário Felipe , dos Santos Fernando M. , Batista João M. , Bauab Tais M. , Araújo Angela R. , Carlos Iracilda Z. , Vilegas Wagner , dos Santos Lourdes C. 
Published: February 2019

AbstractThree new benzaldehyde derivatives, sporulosaldeins A – C (1–3), and 3 new benzopyran derivatives, sporulosaldeins D – F (4–6), were discovered from an endophytic fungus, Paraphaeosphaeria sp. F03, which was isolated from Paepalanthus planifolius leaves. Compounds 1–6 were elucidated by 1- and 2-dimensional nuclear magnetic resonance experiments and high-resolution mass spectrometry analysis. The absolute configuration of compound 5 was determined through the comparison of experimental and calculated electronic circular dichroism data. Compounds 1–6 were found to exhibit antifungal activity with minimum inhibitory concentration (MIC) values of 7.8 – 250 µg/mL and racemic mixture of compound 6 exhibited weak cytotoxicity against MCF-7 and LM3 with IC50 values of 34.4 and 39.2 µM, respectively.
Four New Cytotoxic Arborinane-Type Triterpenes from the Endolichenic Fungus Myrothecium inundatum
Authors: Basnet Buddha Bahadur , Liu Li , Chen Baosong , Suleimen Yerlan Melsuly , Yu Haiyang , Guo Shouyu , Bao Li , Ren Jinwei , Liu Hongwei 
Published: February 2019

AbstractTwo new arborinane-type triterpenes, myrotheols A (1) and B (2), two new arborinane-type glycosides, myrothesides C (3) and D (4), together with four known diterpenes (5 – 8) were isolated from the ethyl acetate extract of the endolichenic fungus Myrothecium inundatum. The structures of new compounds 1 – 4 were elucidated by NMR and MS analyses. The absolute configuration of 1 was assigned by a single-crystal X-ray diffraction experiment. Compounds 3 and 4 represent the first two natural 4-O-methyl-α-D-mannosides. Compounds 1 – 8 exhibited cytotoxicity against K562 and RKO human cancer cell lines.
Syntheses of Post-Iboga Alkaloids
Authors: Lim Hyeonggeun , Seong Sikwang , Han Sunkyu 
Published: February 2019

Post-iboga alkaloids are secondary metabolites that are biosynthetically derived from iboga-type alkaloids via rearrangements of the indole and/or isoquinuclidine moieties. Herein, we categorize post-iboga alkaloids into five types based on the biosynthetic mode of transformation of the iboga scaffold. We then describe reported syntheses of post-iboga alkaloids, including our laboratory’s recent contributions, based on our own categorization.1	Introduction1.1	Iboga and Post-Iboga Alkaloids1.2	Classification of Post-Iboga Alkaloids1.2.1	Introduction to Type I Post-Iboga Alkaloids1.2.2	Introduction to Type II Post-Iboga Alkaloids1.2.3	Introduction to Type III Post-Iboga Alkaloids1.2.4	Introduction to Type IV Post-Iboga Alkaloids1.2.5	Introduction to Type V Post-Iboga Alkaloids2	Syntheses of Post-Iboga Alkaloids2.1	Syntheses of Type I Post-Iboga Alkaloids2.1.1	Syntheses of Monomeric Type I Post-Iboga Alkaloids2.1.2	Syntheses of Dimeric Type I Post-Iboga Alkaloids2.2	Syntheses of Type II Post-Iboga Alkaloids2.3	Synthetic Studies Toward Type III Post-Iboga Alkaloids2.4	Syntheses of Type IV Post-Iboga Alkaloids2.5	Synthesis of Type V Post-Iboga Alkaloids3	Conclusion and Outlook
Human Platelet Acetylcholinesterase: The Effects of Anticholinesterases on Platelet Function
Authors: Smith Martin J , Braem Boyd , Davis Kent D 
Published: February 2019

SummaryPlatelet acetylcholinesterase (AChE) activity was measured in gel-filtered platelet preparations. Three different anticholinesteratic agents (eserine, neostigmine, and diiso- propylphosphorofluoridate) at final concentrations of 10 μM caused complete inhibition of AChE activity after 30 min incubation at room temperature with either platelet-rich plasma or gel-filtered platelets. Complete inhibition of platelet AChE had no effect on platelet aggregation, factor-3 availability, and plasma clot retraction. We conclude that platelet membrane AChE activity is not required for normal platelet function as measured by these in vitro parameters.
Relación entre IPSS y uroflujometría en pacientes con síntomas urinarios
Authors: Fonseca Carmen Liliana , Oliveros Carlos Isaías , Escobar Rebeca , Azuero Julián , Daza Almendrales Fabián 
Published: February 2019

Introducción Los cuestionarios clínicos para los síntomas urinarios se diseñaron para objetivar los síntomas urinarios y de esa forma evitar estudios invasivos y costosos, con la división entre síntomas urinarios de vaciado y llenado, sin embargo, los pacientes presentan síntomas que hacen difícil el discernimiento entre obstrucción infravesical, detrusor hipocontractil o incluso detrusor hiperactivo.Determinar la correlación entre la uroflujometría y la severidad de los síntomas usando el IPSS (International Prostate Symptom Score) en pacientes síntomas urinarios, comparados con urodinamia y determinar su correlación con el diagnostico de obstrucción infravesical, detrusor hipocontráctil o detrusor hipocontráctil
Métodos Estudio retrospectivo en el cual se recolectaron 27 hombres que consultaron por síntomas urinarios de vaciado y asistieron al Hospital Universitario de la Samaritana en Bogotá, Colombia entre abril del 2016 y abril del 2017. El IPSS se realizó a todos los pacientes con el cuestionario autoadministrado. Adicionalmente se realizó uroflujometría y urodinamia con el equipo de urodinámia Medical Measurement System SN077116.
Resultados La edad promedio fue 67,26 años (37–86), IPSS leve del 22%, moderado 59% y severo 19%, con patrones de uroflujometricos campana 26%, meseta 41% intermitente 33%, el 37% presentaron un Qmax menor del 10%, el cual se consideró obstructivo y una PdetQmax menor de 40, en un 37%, lo cual es congruente con los resultados de la uroflujometria, además de relacionarse con residuo postmiccional elevado.
Conclusión Existe una correlación entre el IPSS y el Qmax, comparado con patrones urodinámicos, la utilización de los índices como métodos no invasivos para el ahorro de costos si es comparable con hallazgos urodinámicos. Sin embargo, existe un porcentaje no despreciable de pacientes con Qmax menor de 10 que no corresponden a obstrucción infravesical. Es necesario tener en cuenta que hasta el 23% de los pacientes pueden presentar IPSS moderado o severo sin que el origen sea obstructivo.
Correlation between Second to Fourth Digit Ratio and Anthropometric Variables Indicative of Cardiovascular Disease
Authors: Swami Shveta , Buddhiraja Virender , Gupta Rimpi , Bansal Swati , Gaur Neha , Sharma Deepak 
Published: February 2019

AbstractSecond to fourth digit ratio (2D:4D) is a sexually dimorphic biometric marker. Regarding indirect evidence, there have been several studies that link the waist-to-hip ratio (WHR) with the 2D:4D ratio. If the 2D:4D ratio is associated with testosterone and estrogen levels, it may be correlated with a risk of myocardial infarction (MI). The aim of the present study is to find out the correlation between anthropometric risk factors for cardiovascular disease and the 2D:4D ratio in 250 young females of the state of Haryana in Northern India. The present study was conducted on 250 females of the Haryana population aged between 17 and 35 years old. A series of 8 anthropometric measurements was obtained from the participants: height, weight, 2D:4D ratio, body mass index (BMI), waist circumference (WC), hip circumference (HC), neck circumference (NC), and WHR. The data was collected, tabulated and subjected to statistical computation using SPSS Statistics for Windows, Version 13.0 (SPSS Inc., Chicago, IL, USA). Strong positive associations between the NC and the WHR confirm that both measures are indicative of body fat. Also, a positive correlation between the 2D:4D ratio and the WHR suggests that low androgen levels in women are associated with a greater risk of obesity. Moreover, this result, as well as the positive correlation between 2D:4D ratios and NC, suggest that the digit ratio is indicative for being overweight in women and suggest a predisposition toward cardiovascular disease – however, these correlations of body measurements with digit ratios are not significant.
Comparison of Endotracheal Reintubation between Nasal High-Frequency Oscillation and Continuous Positive Airway Pressure in Neonates
Authors: Thatrimontrichai Anucha , Sirianansopa Kantisa , Janjindamai Waricha , Dissaneevate Supaporn , Maneenil Gunlawadee 
Published: February 2019

Objective This study aimed to compare the endotracheal reintubation between nasal high-frequency oscillation (nHFO) and nasal continuous positive airway pressure (nCPAP) with face mask groups who were followed up for up to 7 days.
Study Design We performed a retrospective cohort study of extubated neonates admitted between 2013 and 2017. We used a Cox's proportional hazards model to adjust for significant between-group differences in baseline characteristics.
Results One hundred and ninety-nine neonates were on either nHFO or nCPAP after extubation. The median (interquartile range) gestational age and birth weight were 31 (29, 33) weeks and 1,450 (1,065, 1,908) grams, respectively. From the univariate analysis, gestational age, ventilator modes, mean airway pressure, fraction of inspired oxygen, oxygen index, caffeine therapy, and initial continuous positive airway pressure level were significantly different between the nHFO and nCPAP groups. There was no significant difference in the 7-day reintubation rate of neonates on nHFO compared with nCPAP (hazard ratio: 2.39; 95% confidence interval: 0.97–5.84; p = 0.05). By multivariate analysis, there was no statistically significant difference of reintubation rate between nHFO and nCPAP by Cox's proportional hazards model.
Conclusion The nHFO mode with face mask is the choice for noninvasive ventilation to prevent reintubation during the week following extubation.
Artificial intelligence may help in predicting the need for additional surgery after endoscopic resection of T1 colorectal cancer
Authors: Ichimasa Katsuro , Kudo Shin-ei , Mori Yuichi , Misawa Masashi , Matsudaira Shingo , Kouyama Yuta , Baba Toshiyuki , Hidaka Eiji , Wakamura Kunihiko , Hayashi Takemasa , Kudo Toyoki , Ishigaki Tomoyuki , Yagawa Yusuke , Nakamura Hiroki , Takeda Kenichi , Haji Amyn , Hamatani Shigeharu , Mori Kensaku , Ishida Fumio , Miyachi Hideyuki 
Published: February 2019

Abstract
Background and study aims Decisions concerning additional surgery after endoscopic resection of T1 colorectal cancer (CRC) are difficult because preoperative prediction of lymph node metastasis (LNM) is problematic. We investigated whether artificial intelligence can predict LNM presence, thus minimizing the need for additional surgery.
Patients and methods Data on 690 consecutive patients with T1 CRCs that were surgically resected in 2001 – 2016 were retrospectively analyzed. We divided patients into two groups according to date: data from 590 patients were used for machine learning for the artificial intelligence model, and the remaining 100 patients were included for model validation. The artificial intelligence model analyzed 45 clinicopathological factors and then predicted positivity or negativity for LNM. Operative specimens were used as the gold standard for the presence of LNM. The artificial intelligence model was validated by calculating the sensitivity, specificity, and accuracy for predicting LNM, and comparing these data with those of the American, European, and Japanese guidelines.
Results Sensitivity was 100 % (95 % confidence interval [CI] 72 % to 100 %) in all models. Specificity of the artificial intelligence model and the American, European, and Japanese guidelines was 66 % (95 %CI 56 % to 76 %), 44 % (95 %CI 34 % to 55 %), 0 % (95 %CI 0 % to 3 %), and 0 % (95 %CI 0 % to 3 %), respectively; and accuracy was 69 % (95 %CI 59 % to 78 %), 49 % (95 %CI 39 % to 59 %), 9 % (95 %CI 4 % to 16 %), and 9 % (95 %CI 4 % – 16 %), respectively. The rates of unnecessary additional surgery attributable to misdiagnosing LNM-negative patients as having LNM were: 77 % (95 %CI 62 % to 89 %) for the artificial intelligence model, and 85 % (95 %CI 73 % to 93 %; P < 0.001), 91 % (95 %CI 84 % to 96 %; P < 0.001), and 91 % (95 %CI 84 % to 96 %; P < 0.001) for the American, European, and Japanese guidelines, respectively.
Conclusions Compared with current guidelines, artificial intelligence significantly reduced unnecessary additional surgery after endoscopic resection of T1 CRC without missing LNM positivity.
Resurrecting ‘Lucifer’: The Transmedia Mythology of Harry Lime
Authors: Freer Scott 
Published: February 2019

AbstractThis essay examines the transmedia mythology of the popular but also ‘evil’ character, Harry Lime, who, in The Third Man (1949) written by Graham Greene and directed by Carol Reed, is shot dead in the sewers of postwar Vienna. The romance of Lime begins with a famous ‘Wellesian’ performance, with Orson Welles drawing on a tradition of Shakespearean ‘heroic-acting’, and Reed’s alteration of Greene’s ‘happy’ closure that effectively underscores Hannah Schmidt’s hero-worshipping of a cult criminal figure. Both creative interventions established the platform for Lime’s ‘resurrection’ in the radio series, The Lives of Harry Lime (1951–52), the television series, The Third Man (1959–65), and Orson Welles’ film, Mr. Arkadin (1955). I argue that the moral rehabilitation of Greene’s fallen figure is indicative of postwar conformist entertainment industry and folk nostalgia for the wartime black marketeer as well as the differing ‘moral codes’ operating across transmedia platforms. But, whereas the radio and TV serializations conscript Lime into the detective-agent genre by burying the evil results of his penicillin racket, Mr. Arkadin de-romanticizes Lime and in turn exposes the cultural amnesia of the 1950s by returning to the 1949 film’s morality and Faustian image of a sadistic racketeer. Written in the spirit of Hans Blumenberg’s theory of myth-adaptation as ongoing ‘points of departure’, this essay debates the ethical issues at stake in this character-oriented misappropriation whereby the protagonist’s moral status is transformed across media platforms.
Parameter balancing: consistent parameter sets for kinetic metabolic models
Authors: Lubitz Timo , Liebermeister Wolfram 
Published: February 2019

Abstract

Summary
Measured kinetic constants are key input data for metabolic models, but they are often uncertain, inconsistent and incomplete. Parameter balancing translates such data into complete and consistent parameter sets while accounting for predefined ranges and physical constraints. Based on Bayesian regression, it determines a most plausible parameter set as well as uncertainty ranges for all model parameters. Our tools for parameter balancing support standard model and data formats and enable an easy customization of prior distributions and constraints for biochemical constants. Modellers can balance kinetic constants, thermodynamic data and metabolomic data to obtain thermodynamically consistent metabolic states that comply with user-defined flux directions.

Availability and implementation
An online tool for parameter balancing, a stand-alone Python command line tool, a Python package and a Matlab toolbox (which uses the CPLEX solver) are freely available at www.parameterbalancing.net.
LIONS: analysis suite for detecting and quantifying transposable element initiated transcription from RNA-seq
Authors: Babaian Artem , Thompson I Richard , Lever Jake , Gagnier Liane , Karimi Mohammad M , Mager Dixie L 
Published: February 2019

Abstract

Summary
Transposable elements (TEs) influence the evolution of novel transcriptional networks yet the specific and meaningful interpretation of how TE-derived transcriptional initiation contributes to the transcriptome has been marred by computational and methodological deficiencies. We developed LIONS for the analysis of RNA-seq data to specifically detect and quantify TE-initiated transcripts.

Availability and implementation
Source code, container, test data and instruction manual are freely available at www.github.com/ababaian/LIONS.

Supplementary information
Supplementary data are available at Bioinformatics online.
Anduril 2: upgraded large-scale data integration framework
Authors: Cervera Alejandra , Rantanen Ville , Ovaska Kristian , Laakso Marko , Nuñez-Fontarnau Javier , Alkodsi Amjad , Casado Julia , Facciotto Chiara , Häkkinen Antti , Louhimo Riku , Karinen Sirkku , Zhang Kaiyang , Lavikka Kari , Lyly Lauri , Pal Singh Maninder , Hautaniemi Sampsa 
Published: February 2019

Abstract

Summary
Anduril is an analysis and integration framework that facilitates the design, use, parallelization and reproducibility of bioinformatics workflows. Anduril has been upgraded to use Scala for pipeline construction, which simplifies software maintenance, and facilitates design of complex pipelines. Additionally, Anduril’s bioinformatics repository has been expanded with multiple components, and tutorial pipelines, for next-generation sequencing data analysis.

Availabilityand implementation
Freely available at http://anduril.org.

Supplementary information
Supplementary data are available at Bioinformatics online.
Significant functional mitral regurgitation affects left atrial function in heart failure patients: haemodynamic correlations and prognostic implications
Authors: Palmiero Giuseppe , Melillo Enrico , Ferro Adele , Carlomagno Guido , Sordelli Chiara , Ascione Raffaele , Monda Vittorio , Severino Sergio , Ascione Luigi , Caso Pio 
Published: February 2019

Abstract

Aims
Functional mitral regurgitation (FMR) is a well-known pathophysiological factor in heart failure (HF) patients, and left atrial function (LAF) is a novel determinant of clinical status and outcome in this setting. However, little is known about the pathophysiological role of FMR on LAF in HFrEF patients. Aim of this study is to explore the possible interplay between the severity of FMR and LAF in heart failure with reduce ejection fraction (HFrEF) patients and their possible consequences.

Methods and results
We studied 97 consecutive patients with FMR classified in two groups: mild-to-moderate MR ore less (FMR group, n = 38) and moderate-to-severe or more (SFMR group, n = 59). Using the phasic method, left atrial contractile, conduit, reservoir, and total emptying function (TLAEF) were calculated to assess LAF. SFMR group showed significantly lower values of LAF compared to FMR group. LA dysfunction (LA-dys) was defined for TLAEF values below the median and groups divided in four subgroups based on its presence. Patient with LA-Dys in SFMR group showed a worse clinical status, higher incidence of right ventricular dysfunction (RV-Dys), and pulmonary hypertension (PH), and a significant worse clinical survival compared to all other groups.

Conclusion
In our study, the survival was significantly lower in SFMR/LA-Dys+ group. Furthermore, LA-Dys was strongly related with worse clinical status and higher incidence of PH and RV-Dys. These results suggest that in patients with SFMR and HFrEF, LA-Dys may represent both a marker of more advanced disease and a novel prognostic factor.
The Inhabitants of the British Isles on the First Crusade: Medieval Perceptions and the Invention of a Pan-Angevin Crusading Heritage
Authors: Parsons Simon Thomas 
Published: February 2019

Abstract
This article critically examines the Latin and vernacular evidence for participation from the British Isles in the expeditions associated with the First Crusade (1096–99), bringing together for the first time the full array of relevant medieval material which suggests such involvement. Although contemporary accounts of the crusade emphasise the universality of Pope Urban II’s appeal within Western Europe, there is very little reliable evidence that England, Scotland, Wales or Ireland contributed any sizeable force to the Christian armies travelling overland to the East, demonstrating that the early crusading recruitment was often culturally and geographically restricted. This article adds to the narrow corpus of material depicting insular contribution to the crusade the testimony of the Siège d’Antioche, a lengthy epic Anglo-Norman poem, which retrospectively inscribed the involvement of peoples from the British Isles onto the narrative of the First Crusade. It suggests furthermore, based on thematic and stylistic evidence, as well as direct textual references, that at least one stage in the development of this extant narrative should be associated with the Angevin literary milieu during the rule of Henry II (1154–89) and his sons. Its portrayal of crusaders from Ireland, Wales, Scotland and England shows that, in the late twelfth-century Angevin realms, the crusade, retrospectively viewed as a central site of Christian heritage and memory and a crucible for the formation of knightly and heroic values, could not be envisaged without the involvement of the wider Angevin world.
The role of consumer age and financial profit in vendor compliance for underage alcohol sales
Authors: Van Hoof Joris J 
Published: February 2019

Abstract
Age limit restriction for risky products is widely implemented as an instrument to improve public health. To study reasons for vendor (non-)compliance this 2 (underage vs. adult consumer) × 2 (low vs. high profit) field experimental research was conducted. Trained mystery shoppers conducted 218 alcohol purchase attempts. ID checks and compliance were significantly higher when financial profit was low (74% ID checks; 67% compliance) compared with the high-profit conditions (26%; 18%). There were no significant differences between the adult and underage consumer conditions. The motivation to comply appears to be the crucial factor, and enforcement needs to be intensified.
Time dependence of cellular responses to dynamic and complex strain fields
Authors: Chagnon-Lessard Sophie , Godin Michel , Pelling Andrew E 
Published: February 2019

Abstract
Exposing cells to an unconventional sequence of physical cues can reveal subtleties of cellular sensing and response mechanisms. We investigated the mechanoresponse of cyclically stretched fibroblasts under a spatially non-uniform strain field which was subjected to repeated changes in stretching directions over 55 h. A polydimethylsiloxane microfluidic stretcher array optimized for complex staining procedures and imaging was developed to generate biologically relevant strain and strain gradient amplitudes. We demonstrated that cells can successfully reorient themselves repeatedly, as the main cyclical stretching direction is consecutively switched between two perpendicular directions every 11 h. Importantly, from one reorientation to the next, the extent to which cells reorient themselves perpendicularly to the local strain direction progressively decreases, while their tendency to align perpendicularly to the strain gradient direction increases. We demonstrate that these results are consistent with our finding that cellular responses to strains and strain gradients occur on two distinct time scales, the latter being slower. Overall, our results reveal the absence of major irreversible cellular changes that compromise the ability to sense and reorient to changing strain directions under the conditions of this experiment. On the other hand, we show how the history of strain field dynamics can influence the cellular realignment behavior, due to the interplay of complex time-dependent responses.