bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Assessment of Post‐Fatigue Resistance of Mandibular First Molars Restored With Polyether Ether Ketone and Lithium Disilicate Endocrowns
Authors: Amjadi Mehrak , Safari Mohammad Raouf , Dini Torkamani Ramin , Kheiri Manjili Mohammadsepehr , Jamshidi Davoud , Sobhan Fatemeh , Heidari Soolmaz 
Published: November 2024

Background and Objectives: Contemporary dentistry focuses on more conservative treatment options such as endocrown restorations and application of dental materials with higher resemblance to tooth structure. Polyether ether ketone (PEEK) polymer is a material used for the fabrication of endocrowns. This study aimed to compare the post‐fatigue resistance (PFR) of mandibular first molars restored with PEEK and lithium disilicate (LS2) endocrown restorations.Materials and Methods: This in vitro, experimental study was conducted on 20 human mandibular first molars with similar dimensions. The teeth were prepared for endocrown restoration and were assigned to two groups (n = 10) of PEEK and LS2 endocrowns. After fabrication by the computer‐aided design and computer‐aided manufacturing (CAD‐CAM) technique, the restorations were cemented with resin cement. Next, the teeth underwent 15,000 thermal cycles followed by cyclic loading with 600,000 cycles of compressive force (100 N, 4 Hz) and were then subjected to compressive load application in a universal testing machine. The load causing endocrown failure was recorded as the PFR of the respective restoration. The failure mode was also inspected under a light microscope. Data were analyzed by the independent t‐test and also chi‐square, Mann–Whitney, and Fisher’s exact tests (α < 0.05).Results: The teeth with PEEK endocrowns showed significantly higher PFR than those with LS2 endocrowns. Irreparable fractures were dominant in both groups.Conclusion: PEEK may serve as a suitable alternative to LS2 for the fabrication of endocrown restorations.
Insights from Nowcasting and Mesoscale Research Working Group Projects of the World Weather Research Programme
Authors: Joe Paul , Ebert Elizabeth , Keenan Tom , Wang J.J. , Duan Yihong , Isaac George , Wang Yong , Kiktev Dmitry , Li Ping Wah , Saito Kazuo , Lee Gyu Won , Masson Valéry , Brown Barb , Onvlee-Hooimeijer Jeanette , Steinle Peter , Salio Paola , Albrecht Rachel , Wilson Jim , Roberts Rita , Sun Juanzhen , Liang Feng , Saulo Celeste , Campetella Claudia , Goodman Steve , Conway Bill , Doyle Chris , Bélair Stéphane , Milbrandt Jason , Leroyer Sylvie , Montmerle Thibaut , Filho Augusto Jose Pereira , Golding Brian , May Peter , Seed Alan , Wang Yinchun , Michelson Daniel , Baklanov Alexander , de Coning Estelle 
Published: November 2024

Abstract
Insights from Forecast Demonstration Projects and Research Development Projects, training workshops and symposia, conducted between 2000 and 2024 are summarized. The projects were organized by the Nowcasting and Mesoscale Research Working Group of the World Weather Research Program of the World Meteorological Organization. The objective was to advance, promote and build capacity in nowcasting and very short-range forecasting. The projects were associated with the Olympic Games, emergency management and aviation services. They brought international experts together to work in a collaborative fashion. Extensive interaction with end-users and decision-makers expanded and extended the scope of services from traditional weather hazards (heavy rain, wind, hail, lightning) to include specific user needs (e.g., visibility in complex terrain or airport runways, periods of calm winds or light rain, heat stress). Substantial progress has been made in many areas including: advanced radar nowcasting algorithms, stochastic nowcasts, kilometric and hectometric numerical weather prediction models; blending of observations and models and multi-model systems. Verification was a key and valuable component of the projects quantifying the results. Also, the types of services have expanded to include both summer and winter services, complex terrain and urban environments, air transport, air quality, hydrology and health. Insights are presented in all aspects of nowcasting and very short-range forecasting from end-user decision-making, critical role of the forecaster, forecast systems (models, heuristics, observations), to science and knowledge gaps.
The impact of high-intensity interval training on insulin sensitivity and quality of life in women with overweight polycystic ovary syndrome
Authors: Jiang Ling , Chen Yaxin , Huang Meiying 
Published: November 2024

Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, characterized by menstrual irregularities, hyperandrogenism, and polycystic ovaries. Insulin resistance is central to its pathophysiology, contributing to metabolic disturbances and increased cardiometabolic risks. High-Intensity Interval Training (HIIT) has emerged as a promising intervention to improve metabolic health. Objective This study aimed to investigate the specific effects of HIIT on insulin sensitivity, body composition, metabolic profile, and quality of life in women with overweight PCOS. Methods A retrospective analysis was conducted on 107 female patients with overweight PCOS who were divided into two groups: the Regular Interval Training Group (n = 54) and the HIIT Group (n = 53). Baseline data, including insulin sensitivity, glucose metabolism, body composition, metabolic profile, and quality of life, were measured and compared between the two groups. Results The HIIT Group demonstrated significantly improved insulin sensitivity, reduced fasting glucose levels, lower HOMA-IR index, lower body fat percentage, decreased waist and hip circumferences, improved favorable changes in metabolic profile, and significant improvements in quality of life compared to the Regular Interval Training Group. These findings suggest that HIIT led to beneficial outcomes across various metabolic and clinical parameters in women with overweight PCOS. Conclusion The findings of this study highlight the potential of personalized exercise prescriptions, such as HIIT, in optimizing health outcomes in women with overweight PCOS. The observed improvements in insulin sensitivity, body composition, metabolic profile, and quality of life underscore the promising role of HIIT in addressing the multifaceted implications of PCOS and its associated metabolic and reproductive implications.
Lycorine ameliorates liver steatosis, oxidative stress, ferroptosis and intestinal homeostasis imbalance in MASLD mice
Authors: Wang Ziwen , Zhu Mengpei , Li Qian , Cao Jiali , Zhong Qiangqiang , Jin Ze , Huang Yumei , Lan Qing , Gao Ya , Xiong Zhifan 
Published: November 2024

Abstract
Background
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease worldwide and few drugs are available for its treatment. Lycorine has effective anti-inflammatory and lipid-lowering effects, but the impact on MASLD is not fully understood. In this study, we intend to test the intervention effect of lycorine on MASLD.

Methods
A MASLD mouse model was constructed on a high-fat diet for 16 weeks, and low, medium, and high doses of lycorine were given by gavage for the last 4 weeks. Detecting indicators related to liver steatosis, oxidative stress, and ferroptosis. In vivo and in vitro experiments co-validate potential targets identified by network pharmacology, molecular docking and western blot for lycorine intervention in MASLD liver. A combination of pathology, western blot, qRT-PCR, and 16 S rRNA sequencing verified adipose tissue and intestinal alterations.

Results
Lycorine ameliorated hepatic steatosis, oxidative stress and ferroptosis in MASLD mice by inhibiting the expression of phosphorylated EGFR, inhibiting the PI3K/AKT signaling pathway. We also observed a dose-dependent effect of lycorine to improve some of the indicators of MASLD. In vitro, knockdown of EGFR significantly attenuated palmitic acid-induced hepatocyte steatosis. In addition, lycorine promoted WAT browning for thermogenesis and energy consumption, affected the composition of intestinal flora, improved the intestinal barrier, and reduced intestinal inflammation.

Conclusions
EGFR was the target of lycorine intervention in MASLD. Lycorine ameliorated hepatic steatosis, oxidative stress and ferroptosis by affecting the EGFR/PI3K/AKT signaling pathway in MASLD mice. Furthermore, lycorine promoted WAT browning and ameliorated intestinal homeostatic imbalance. The above effects may also have dose-dependent effects.
Prehospital telemedicine support for urban stroke care: Analysis of current state of care and conceptualization
Authors: Weiss Daniel , Rubbert Christian , Kaschner Marius , Greiner Gregory Gordon , Kairies-Schwarz Nadja , Vomhof Markus , Icks Andrea , Weitz Linea , Hollenberg Hanna , Jansen Robin , Menge Til , Seitz Rüdiger J. , Jander Sebastian , Bernhard Michael , Lee John-Ih , Ruck Tobias , Meuth Sven Guenther , Turowski Bernd , Caspers Julian , Gliem Michael 
Published: November 2024

Abstract
Background
The reduction of processing times in the treatment of acute ischemic stroke is of outstanding importance. Our objective is to analyze the acute stroke care chain from onset to treatment in a city in Germany comprising three stroke units. Additionally, we discuss solutions for detected treatment delays.

Methods
We conducted an in-depth analysis of acute stroke care processing times across three local stroke centers in Düsseldorf among all emergency services transportations for suspected stroke. Isochrone mapping was performed to identify areas with prolonged transportation times.

Results
Among the 1,714 transportations, 943 patients had confirmed strokes. Prehospital care constituted 58% of total emergency care time until imaging. Patients with confirmed stroke had reduced in-hospital times while patients receiving treatment experienced faster in-hospital times. Isochrone mapping revealed disparities in transportation times within the city.

Conclusions
In conclusion, we identified confirmation of stroke symptoms as pre- and in-hospital and treatment eligibility as in-hospital process accelerators in stroke care. We propose the introduction of an in-ambulance video consulting model to accelerate contact to stroke-experts and accelerate processing times for patients eligible for treatment. Furthermore, we discuss the combination of in-ambulance video consulting with imaging and starting treatment outside traditional stroke centers, followed by transportation to a stroke center during thrombolysis, which might further accelerate treatment in specific cases.
The relationship between serum levels of LOX-1, hs-cTnT, NGAL, and renal function, and their diagnostic value in patients with chronic kidney disease: a retrospective study
Authors: Chai Liyin , Zeng Jun , Gong Li , Li Zhuhong , Wang Fang , Liu Zhengyang , Fan Wang , Shen Bingbing 
Published: November 2024

Abstract
Background
The primary aim of this study is to explore the relationship between serum levels of LOX-1, hs-cTnT, and NGAL, and renal function in patients with CKD, as well as to evaluate their diagnostic value for early detection and monitoring of disease progression in CKD patients.

Methods
A retrospective study was conducted on 108 patients with chronic kidney disease admitted to our hospital from January 2023 to December 2023. The patients were divided into the mild renal insufficiency group (51 cases) and the severe renal insufficiency group (57 cases). The differences in serum levels of LOX-1, hs-cTnT, and NGAL between the two groups were compared, and Pearson correlation analysis was used to explore the relationship between the three levels and renal function. ROC analysis was used to evaluate the predictive value of the three markers for the diagnosis of CKD.

Results
The levels of LOX-1, hs-cTnT, and NGAL in the mild renal insufficiency group were lower than those in the severe renal insufficiency group (P < 0.05). Correlation analysis showed that serum levels of LOX-1, hs-cTnT, and NGAL were positively correlated with the deterioration of renal function (P < 0.001), indicating a significant correlation between LOX-1, hs-cTnT, NGAL levels, and the deterioration of renal function. ROC analysis showed that the AUC of serum levels of LOX-1, hs-cTnT, and NGAL were 0.859, 0.882, and 0.841, indicating a significant predictive value for the diagnosis of chronic kidney disease.

Conclusion
Serum levels of LOX-1, hs-cTnT, NGAL, and related markers demonstrate a direct association with the extent of renal impairment, offering predictive capabilities for diagnosing CKD.
A systematic scoping review of mentoring support on professional identity formation
Authors: Krishna Lalit Kumar Radha , Kwok Hannah Yi Fang , Ravindran Nila , Tan Xuan Yu , Soh Jasper , Wan Darius Wei Jun , Rajalingam Varsha , Lua Jun Kiat , Leong Elizabeth Yong Mei , Low Tiat Yan , Chan Aiden Wei-Jun , Lim Chong Jin Nicholas , Ng Yen Kit , Thenpandiyan Arthena Anushka , Lim Adele Yi Dawn , Tse Leia Ning , PL Sriram , Rajanala Sri Priyanka , Leong Jun Rey , Quah Elaine Li Ying , Fam Victoria Jia En , Govindasamy Ranitha , Abdul Hamid Nur Amira Binte , Lim Crystal , Sim Dorsett Shin Wei , Ong Eng Koon , Mason Stephen , Somasundaram Nagavalli , Ong Simon Yew Kuang 
Published: November 2024

Abstract
Background
Mentoring’s success in nurturing professional identity formation (PIF) has been attributed to its ability to build personalised and enduring mentoring relationships. However, beyond functioning as communities of practice (CoPs) supporting socialisation processes, how mentoring integrates programme values and instils a shared identity amongst mentees remains unclear. The need for personalised guidance and timely attention to a mentee’s unique needs in evolving mentoring relationships point to the critical role of support mechanisms (‘mentoring support’). We conducted a systematic scoping review (SSR) studying “What is known about mentoring support’s role in nurturing PIF?”.

Methods
Adopting PRISMA-ScR guidelines, this SSR was guided by the Systematic Evidence-Based Approach (SEBA). Independent searches were carried out on publications featured between 1st January 2000 and 30th June 2023 in PubMed, Embase, ERIC and Scopus databases. The Split Approach saw concurrent, independent thematic and content analyses of the included articles. The Jigsaw Perspective combined complementary themes and categories, creating broader themes/categories. The subsequent Funnelling Process formed key domains that platformed the synthesis of the discussion.

Results
Two thousand three hundred forty-one abstracts were reviewed, 323 full-text articles were appraised and 151 articles were included and analysed. The key domains identified were (1) definitions and roles; (2) personalisation; (3) shepherding; and (4) PIF.

Conclusion
The success of mentoring in PIF lies in its ability to blend role modelling, supervision, mentoring, coaching and teaching, with self-care, guided reflection, apprenticeship and assessment to meet the individual needs of the mentee and their changing circumstances. Blending the contents of the mentoring umbrella emphasises the critical role of the mentor and host organisation in supporting mentor training, communications, support and assessment mechanisms. Mentee engagement and its active role in support measures complement the CoP-like mentoring programme’s use of blending mentoring support to advance the socialisation process. These insights reflect a complex interactive process scaffolding the development of mentoring relationships and PIF. The effect of the mentoring umbrella on clinical practice requires further study.
Understanding the effectiveness and quality of virtual cancer multidisciplinary team meetings (MDTMs): a systematic scoping review
Authors: Onifade Anjola , Quaife Samantha L. , Holden David , Chung Donna , Birchall Martin , Peake Michael D. , Mughal Muntzer , McInnerney Daisy 
Published: November 2024

Abstract
Introduction
Cancer multi-disciplinary team meetings (MDTM) assemble clinical experts to make diagnostic and treatment recommendations. MDTMs can take place in person, virtually, or in a hybrid format. Virtual and hybrid MDTMs have been in use for over two decades. This systematic scoping review aims to map the evidence on virtual and hybrid MDTM formats over time, providing insights into their quality, and the facilitators and barriers to their effective delivery.

Methods
The PRISMA scoping review checklist has been followed. A systematic search of PubMed, PsychINFO, and Embase between 1990–2023 identified 9399 records. These were independently screened by two researchers to identify primary research of any design that assessed quality or effectiveness of cancer VMDTMs. Results were narratively synthesised.

Results
Eight quantitative, two qualitative and three mixed-methods studies were included. All were observational and most were retrospective (n = 8). Varied outcome measures were used to evaluate meeting quality, including treatment recommendations, survival, time from diagnosis, and overall attendance. VMDTMs were superior (N = 6) or sometimes equivalent (N = 4) to face-to-face meetings. Studies identified implementation factors critical to their effective delivery, including internet-stability and chairing.

Conclusion
The heterogeneous literature suggests VMDTMs offer some benefits over face-to-face meetings. Training and infrastructure are key to prevent risks to patient safety. A definitive comparative evaluation is needed to inform best practice.
Optimizing stent retrievers for mechanical enhancement and in vitro testing in acute ischemic stroke models
Authors: Lee Jae-Won , Kim Han-Ki , Kim JinWoo , Choi Hyuk 
Published: November 2024

Abstract
Background
Acute ischemic stroke (AIS) remains a major cause of morbidity and mortality worldwide. Mechanical thrombectomy, especially with stent retrievers, offers a promising treatment, particularly for patients ineligible for intravenous tissue plasminogen activator (IV tPA) therapy. This study aimed to develop and evaluate novel stent retriever designs to enhance mechanical properties and vessel compatibility.

Results
We evaluated four stent designs using finite-element analysis (FEA) to assess their mechanical properties. Based on these evaluations, Stent D emerged as the optimal design due to its superior elasticity and adaptability. Comparative testing of Stent D against commercial stents, Solitaire FR and Trevo XP ProVue, revealed the following metrics: radial forces of 3.77 ± 0.01 N for Solitaire FR, 3.92 ± 0.08 N for Trevo XP ProVue, and 4.10 ± 0.07 N for Stent D; flexibility measurements of 0.38 ± 0.11 N for Solitaire FR, 0.91 ± 0.11 N for Trevo XP ProVue, and 0.59 ± 0.05 N for Stent D; deployment forces of 0.37 ± 0.02 N for Solitaire FR, 0.42 ± 0.04 N for Trevo XP ProVue, and 0.32 ± 0.02 N for Stent D; and recapture forces of 0.38 ± 0.01 N for Solitaire FR, 0.45 ± 0.02 N for Trevo XP ProVue, and 0.35 ± 0.01 N for Stent D. Thrombus retrieval rates were 96.16% for Solitaire FR and 95.51% for Stent D.

Conclusions
These findings demonstrate that Stent D performs comparably to commercial stents, highlighting its effective performance in AIS treatment. Stent D shows promise as a candidate for further clinical evaluation due to its superior mechanical properties and effective thrombus retrieval capabilities.
Biomechanical evaluation of a newly designed locking plate for opening wedge high tibial osteotomy: stress distribution and stability in the presence of lateral hinge fracture
Authors: Park Hyung Jun , Suh Dong Hun , Hong Hyongtaek , Nha Kyung-Wook , Kim Hyungsuh , Kang Kyoung-Tak , Kim Jae Gyoon 
Published: November 2024

Abstract
Background
The study aimed to evaluate whether a new OhtoFix plate reduced stress around the D-hole compared with an old OhtoFix and TomoFix plate. The study also assessed whether the new OhtoFix plate had biomechanical stability in a lateral hinge fracture (LHF).

Methods
A finite element model of the proximal tibia was developed using cross-sectional images from a 62-year-old Asian woman. The model was designed to simulate opening wedge high tibial osteotomy (OWHTO) using three types of locking plates: the newly designed locking plate (new OhtoFix plate), the prior version of the OhtoFix plate (old OhtoFix plate), and the TomoFix plate. The peak von Mises stress (PVMS) was analyzed around the D-hole and across the entire plate including the impact of different LHF types classified according to the Takeuchi classification.

Results
The new OhtoFix plate significantly reduced stress around the D-hole compared with the old OhtoFix and TomoFix plates, with peak stresses of 189.5 MPa, 251.5 MPa, and 233.3 MPa, respectively. Despite this improvement, the new OhtoFix plate did not surpass the TomoFix in terms of overall stress distribution across the entire plate. Additionally, in cases of LHF, although peak stress remained at the D-hole in both the old OhtoFix and TomoFix plates, the peak stress shifted to the C-hole in the new plate.

Conclusions
The new OhtoFix plate improved stress distribution around the D-hole (even in the presence of a LHF) compared to the old OhtoFix plate and TomoFix plates. However, although the new OhtoFix plate reduced peak stress around the D-hole, it did not demonstrate superior overall stress distribution across the entire plate compared to the TomoFix plate.
Transcutaneous auricular vagus nerve stimulation in anesthetized mice induces antidepressant effects by activating dopaminergic neurons in the ventral tegmental area
Authors: Choi Tae-Yong , Kim Jeongseop , Koo Ja Wook 
Published: November 2024

AbstractDepression, a prevalent neuropsychiatric disorder, involves the dysregulation of neurotransmitters such as dopamine (DA). The restoration of DA balance is a pivotal therapeutic target for this condition. Recent studies have indicated that both antidepressant medications and non-pharmacological treatments, such as transcutaneous auricular vagus nerve stimulation (taVNS), can promote recovery from depressive symptoms. Despite the promise of taVNS as a non-invasive depression therapy, its precise mechanism remains unclear. We hypothesized that taVNS exerts antidepressant effects by modulating the DAergic system. To investigate this, we conducted experiments demonstrating that taVNS in anesthetized mice reduced depressive-like behaviors. However, this effect was abolished when DA neurons in the ventral tegmental area (VTADA) were inhibited. Additionally, taVNS in anesthetized mice enhanced VTADA activity, providing further evidence to support its antidepressant effects. Overall, our findings suggest that taVNS alleviates depression by augmenting VTADA activity, thereby contributing to a more comprehensive understanding of its therapeutic mechanisms.
Loss of chromosome cytoband 13q14.2 orchestrates breast cancer pathogenesis and drug response
Authors: Shahrouzi Parastoo , Azimzade Youness , Brankiewicz-Kopcinska Wioletta , Bhatia Sugandha , Kunke David , Richard Derek , Tekpli Xavier , Kristensen Vessela N. , Duijf Pascal H. G. 
Published: November 2024

AbstractBreast cancer (BCa) is a major global health challenge. The BCa genome often carries extensive somatic copy number alterations (CNAs), including gains/amplifications and losses/deletions. These CNAs significantly affect tumor development, drug response and patient survival. However, how individual CNAs contribute is mostly elusive. We identified loss of chromosome 13q14.2 as a key CNA in BCa, occurring in up to 63% of patients, depending on the subtype, and correlating with poor survival. Through multi-omics and in vitro analyses, we uncover a paradoxical role of 13q14.2 loss, promoting both cell cycle and pro-apoptotic pathways in cancer cells, while also associating with increased NK cell and macrophage populations in the tumor microenvironment. Notably, 13q14.2 loss increases BCa susceptibility to BCL2 inhibitors, both in vitro and in patient-derived xenografts. Thus, 13q14.2 loss could serve as a biomarker for BCa prognosis and treatment, potentially improving outcomes for BCa patients.
Graphical abstract