bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Energetics and Magnitude of Hydrometeor Friction in Clouds
Authors: Igel Matthew R. , Igel Adele L. 
Published: March 2018

Abstract
As hydrometeors fall within or from a cloud, they reach a terminal velocity because of friction with the air through which they settle. This friction has previously been shown to result in significant vertically integrated dissipation of energy, but the nature and vertical profile of this dissipation warrant further investigation. Here, its energetic origin is discussed. It is confirmed explicitly that the dissipated energy originates from the conversion of hydrometeor potential energy during settling as suggested in an earlier study by Pauluis and Held. The magnitude of this heating is then analyzed in a cloud-resolving model simulation of tropical, aggregated convection. Maximum heating from hydrometeor friction reaches ~10 K h−1. The simulation is compared to one without hydrometeor frictional heating. For the case simulated, hydrometeor frictional heating results in a drier mean state, greater cloud cover, lessened convective mass flux, and a warmer atmosphere throughout much of the troposphere. It is suggested that the heating imparted to the atmosphere by dissipation allows the air to recover most of the energy previously expended in lofting hydrometeors.
Qualitative Assessment of Blood Washing with the Continuous Autologous Transfusion System (CATS)
Authors: Walpoth B.H. , Eggensperger N. , Walpoth-Aslan B.N. , Neidhart P. , Lanz M. , Zehnder R. , Spaeth P.J. , Kurt G. , Althaus U. 
Published: March 2018

A number of different blood-processing methods can be used at the end of cardiopulmonary bypass (CPB) to improve the quality of autologous blood. They include centrifugation, hemofiltration and cell-washing. They differ in processing time required, cost of disposables and the quality of the processed autologous blood product. The newly developed continuous auto-transfusion system (CATS: Fresenius AG, Bad Homburg) uses a continuous cell-washing method. In a prospective study, the oxygenator blood of 10 patients was processed at the end of cardiac surgery with CATS and the quality of autologous blood before and after processing was compared. The processing volumes and the time required were recorded. The concentrations and elimination rates of blood parameters and waste products such as activated coagulation and complement products were measured. At the end of CPB a mean volume of 1,010 ± 174 ml diluted oxygenator blood was processed and concentrated to 310 ± 88 ml in 11.0 ± 2.2 mins. Cellular elements such as erythrocytes and leucocytes were mostly retained and their concentration showed a significant increase after processing (250% and 210% respectively; p < 0.01). Thus, the blood processing with CATS resulted in an excellent hemoconcentration (hematocrit 62 ± 3 vs. 24 ± 4% before processing) with a consistent reproducibility. On the other hand, the CATS concentrate showed a significant loss of autologous plasma proteins. Likewise, all water soluble elements such as waste products are significantly lower in concentration after processing and, if calculated by quantity, they show a high elimination rate (> 93%). In conclusion, the continuous autologous transfusion system permits an automated, rapid and continuous processing of autologous blood yielding a standardised high quality erythrocyte concentrate.
Stroke Volume Validation and Energy Evaluation for the Dynamic Training of Skeletal Muscle Ventricles
Authors: Klapproth P. , Guldner N.W. , Sievers H.H. 
Published: March 2018

Skeletal muscle ventricles used for cardiac assistance were trained dynamically by shifting volume within an elastic training device. To optimize this dynamic training that is by variation of stimulation patterns and application of drugs, methods for stroke volume and energy evaluation were required. A volume shift induced by a muscle contraction resulted in a pressure rise in the training device. Stroke volume was calculated by relating the pressure difference of a muscle contraction to the device's compliance. For validation of the calculated stroke volume, a mock system was built to simulate muscle contractions under various conditions. The stroke volume measured independently and calculated by means of the pressure rise inside the training device, showed an approximately one-to-one relation (R=0.996). Calculation of delivered energy from skeletal muscle ventricles thereby became possible. This method offers a simple, reliable and practical procedure to quantify the dynamic training of skeletal muscle ventricles for use in cardiac assistance.
Decision Support in Diabetes Care: The Challenge of Supporting Patients in Their Daily Living Using a Mobile Glucose Predictor
Authors: Pérez-Gandía Carmen , García-Sáez Gema , Subías David , Rodríguez-Herrero Agustín , Gómez Enrique J. , Rigla Mercedes , Hernando M. Elena 
Published: March 2018

Background: In type 1 diabetes mellitus (T1DM), patients play an active role in their own care and need to have the knowledge to adapt decisions to their daily living conditions. Artificial intelligence applications can help people with type 1 diabetes in decision making and allow them to react at time scales shorter than the scheduled face-to-face visits. This work presents a decision support system (DSS), based on glucose prediction, to assist patients in a mobile environment. Methods: The system’s impact on therapeutic corrective actions has been evaluated in a randomized crossover pilot study focused on interprandial periods. Twelve people with type 1 diabetes treated with insulin pump participated in two phases: In the experimental phase (EP) patients used the DSS to modify initial corrective decisions in presence of hypoglycemia or hyperglycemia events. In the control phase (CP) patients were asked to follow decisions without knowing the glucose prediction. A telemedicine platform allowed participants to register monitoring data and decisions and allowed endocrinologists to supervise data at the hospital. The study period was defined as a postprediction (PP) time window. Results: After knowing the glucose prediction, participants modified the initial decision in 20% of the situations. No statistically significant differences were found in the PP Kovatchev’s risk index change (–1.23 ± 11.85 in EP vs –0.56 ± 6.06 in CP). Participants had a positive opinion about the DSS with an average score higher than 7 in a usability questionnaire. Conclusion: The DSS had a relevant impact in the participants’ decision making while dealing with T1DM and showed a high confidence of patients in the use of glucose prediction.
Dapagliflozin improves treatment satisfaction in overweight patients with type 2 diabetes mellitus: a patient reported outcome study (PRO study)
Authors: Nakajima Hiroki , Okada Sadanori , Mohri Takako , Kanda Eiichiro , Inaba Naoyuki , Hirasawa Yoko , Seino Hiroaki , Kuroda Hisamoto , Hiyoshi Toru , Niiya Tetsuji , Ishii Hitoshi 
Published: March 2018

AbstractBackgroundThe benefits of sodium glucose cotransporters 2 (SGLT2) inhibitors in patients with type 2 diabetes mellitus include plasma glucose control, reduction in body weight and blood pressure, and low risk of hypoglycemia, although they may also cause genitourinary infections, polyuria, or volume depletion. It is not clear whether dapagliflozin, an SGLT2 inhibitor, improves treatment satisfaction among patients in a comprehensive way despite the negative side effects. This study assessed the effect of dapagliflozin on glycosylated hemoglobin (HbA1c), body weight, and treatment satisfaction in overweight patients with type 2 diabetes mellitus treated with oral hypoglycemic agents.MethodsThis multicenter, open-label, single-arm observational study included patients with type 2 diabetes mellitus administering dapagliflozin 5 or 10 mg per day for 14 weeks. Changes in treatment satisfaction were evaluated using a new version of the Oral Hypoglycemic Agent-Questionnaire (OHA-Q ver. 2) consisting of 23 items. Correlation between treatment satisfaction and HbA1c levels and body weight were analyzed using the Spearman’s rank-correlation coefficient.ResultsOf the 221 patients enrolled, 188 completed the study. Mean HbA1c decreased from 7.8 ± 0.7% (62.1 ± 7.5 mmol/mol) to 7.3 ± 0.8% (55.9 ± 8.7 mmol/mol) (change − 0.6 ± 0.7%,P < 0.001) and body weight decreased from 82.5 ± 14.6 to 80.7 ± 14.8 kg (change − 2.3 ± 2.8 kg,P < 0.001). OHA-Q ver. 2 was validated as well, the mean OHA-Q ver. 2 total score increased from 44.3 ± 9.4 to 46.6 ± 9.8 (best score 69, worst score 0; change 2.3 ± 6.6,P < 0.001). The change in body weight significantly correlated with the OHA-Q ver. 2 total score (Spearman’sρ = − 0.17,P = 0.035). The change in HbA1c levels significantly correlated with the satisfaction subscale score (Spearman’sρ = − 0.19,P = 0.011).ConclusionsDapagliflozin significantly improved treatment satisfaction among patients with type 2 diabetes mellitus for 14 weeks. Body weight loss significantly correlated with treatment satisfaction.Trial registrationUMIN-CTR: UMIN000016304
How shocking: compensating secondary victims for psychiatric injury
Authors: Rix Keith , Cory-Wright Charlie 
Published: March 2018

SUMMARYWhen those whom the law terms ‘secondary victims’ – i.e. the passive and unwilling witnesses of injury, or of the threat of it, to others – seek compensation through the courts for the psychiatric injuries that they have suffered (traditionally but confusingly referred to as ‘nervous shock’ claims), there would in theory be the potential for a virtually limitless number of claims. For this reason, the courts have developed and apply a number of, to a large extent, arbitrary ‘control mechanisms’ as floodgates. This article describes these control mechanisms and other relevant law using recent illustrative cases and with particular reference to the assistance that the courts can expect of psychiatrists as to diagnosis and causation.LEARNING OBJECTIVES•Understand the law relating to the compensation of secondary victims for psychiatric injury•Appreciate the arbitrariness of the application of the law, as demonstrated in particular by recent cases of such claims by secondary victims•Understand the proper role of (and limits of) expert psychiatric evidence in secondary victim cases, and therefore how best to assist the courts in relation to themDECLARATION OF INTERESTNone.
Depression and obesity: can the cycle be broken?
Authors: Romain Karen , Webb Timothy , Kumar Manoj 
Published: March 2018

SUMMARYObesity and depression are conditions that have been linked through a great number of interesting mechanisms. To fully understand the implications of treatment choices it is necessary to continue to investigate the physiology of these two conditions. By examining the background of these problems and considering factors such as stress response, neurological change and systemic inflammation, we propose a cycle linking depression and obesity. With reference to this cycle, we discuss management options, focusing particularly on prescribing choices and current guidelines. An assessment of the medication options is provided demonstrating that prescribing choices can have a significant impact on ongoing physical health. The aim of this discussion is to raise awareness of current research and progress and to see whether the cycle of depression and obesity can be broken.LEARNING OBJECTIVES•Update knowledge of the mechanisms linking depression and obesity•Understand the impact of medication on the cycle linking the two•Consider how we can improve outcomes for patients with depression and/or obesityDECLARATION OF INTERESTNone.
Childhood sexual abuse: disclosure and mandatory reporting – ethical and clinical implications
Authors: Burbridge-James William 
Published: March 2018

SUMMARYThe widespread nature of child sexual abuse is increasingly recognised and in the public domain following high-profile cases. Children and vulnerable people need protecting from such abuse. At the heart of the dilemma facing clinicians is the need to feel supported by the legislative framework to maintain confidentiality and use their clinical discretion in the best interests of their patients, ensuring that they receive the help they need, but also protecting others at risk. There are compelling arguments both for and against strengthening legislation to improve child protection.LEARNING OBJECTIVES•To understand the context for the potential introduction of mandatory reporting.•To understand the arguments for and against mandatory reporting of childhood, including historic, sexual abuse.•To reflect on the implications of mandatory reporting of childhood, including historic, sexual abuse for readers clinical practice.DECLARATION OF INTERESTNone.
Microsimulation Modeling in Oncology
Authors: Çağlayan Çağlar , Terawaki Hiromi , Chen Qiushi , Rai Ashish , Ayer Turgay , Flowers Christopher R. 
Published: March 2018

Purpose Microsimulation is a modeling technique that uses a sample size of individual units (microunits), each with a unique set of attributes, and allows for the simulation of downstream events on the basis of predefined states and transition probabilities between those states over time. In this article, we describe the history of the role of microsimulation in medicine and its potential applications in oncology as useful tools for population risk stratification and treatment strategy design for precision medicine. Methods We conducted a comprehensive and methodical search of the literature using electronic databases—Medline, Embase, and Cochrane—for works published between 1985 and 2016. A medical subject heading search strategy was constructed for Medline searches by using a combination of relevant search terms, such as “microsimulation model medicine,” “multistate modeling cancer,” and “oncology.” Results Microsimulation modeling is particularly useful for the study of optimal intervention strategies when randomized control trials may not be feasible, ethical, or practical. Microsimulation models can retain memory of prior behaviors and states. As such, it allows an explicit representation and understanding of how various processes propagate over time and affect the final outcomes for an individual or in a population. Conclusion A well-calibrated microsimulation model can be used to predict the outcome of the event of interest for a new individual or subpopulations, assess the effectiveness and cost effectiveness of alternative interventions, and project the future disease burden of oncologic diseases. In the growing field of oncology research, a microsimulation model can serve as a valuable tool among the various facets of methodology available.
Exocytosis Protein DOC2B as a Biomarker of Type 1 Diabetes
Authors: Aslamy Arianne , Oh Eunjin , Ahn Miwon , Moin Abu Saleh Md , Chang Mariann , Duncan Molly , Hacker-Stratton Jeannette , El-Shahawy Mohamed , Kandeel Fouad , DiMeglio Linda A , Thurmond Debbie C 
Published: March 2018

Abstract

Context
Efforts to preserve β-cell mass in the preclinical stages of type 1 diabetes (T1D) are limited by few blood-derived biomarkers of β-cell destruction.

Objective
Platelets are proposed sources of blood-derived biomarkers for a variety of diseases, and they show distinct proteomic changes in T1D. Thus, we investigated changes in the exocytosis protein, double C2 domain protein-β (DOC2B) in platelets and islets from T1D humans, and prediabetic nonobese diabetic (NOD) mice.

Design, Patients, and Main Outcome Measure
Protein levels of DOC2B were assessed in platelets and islets from prediabetic NOD mice and humans, with and without T1D. Seventeen new-onset T1D human subjects (10.3 ± 3.8 years) were recruited immediately following diagnosis, and platelet DOC2B levels were compared with 14 matched nondiabetic subjects (11.4 ± 2.9 years). Furthermore, DOC2B levels were assessed in T1D human pancreatic tissue samples, cytokine-stimulated human islets ex vivo, and platelets from T1D subjects before and after islet transplantation.

Results
DOC2B protein abundance was substantially reduced in prediabetic NOD mouse platelets, and these changes were mirrored in the pancreatic islets from the same mice. Likewise, human DOC2B levels were reduced over twofold in platelets from new-onset T1D human subjects, and this reduction was mirrored in T1D human islets. Cytokine stimulation of normal islets reduced DOC2B expression ex vivo. Remarkably, platelet DOC2B levels increased after islet transplantation in patients with T1D.

Conclusions
Reduction of DOC2B is an early feature of T1D, and DOC2B abundance may serve as a valuable in vivo indicator of β-cell mass and an early biomarker of T1D.
The histone acetyltransferase inhibitor Nir regulates epidermis development
Authors: Duteil Delphine , Tourrette Yves , Eberlin Adrien , Willmann Dominica , Patel Dharmeshkumar , Friedrichs Nicolaus , Müller Judith M. , Schüle Roland 
Published: March 2018

ABSTRACT
In addition to its function as an inhibitor of histone acetyltransferases, Nir (Noc2l) binds to p53 and TAp63 to regulate their activity. Here, we show that epidermis-specific ablation of Nir impairs epidermal stratification and barrier function, resulting in perinatal lethality. Nir-deficient epidermis lacks appendages and remains single layered during embryogenesis. Cell proliferation is inhibited, whereas apoptosis and p53 acetylation are increased, indicating that Nir is controlling cell proliferation by limiting p53 acetylation. Transcriptome analysis revealed that Nir regulates the expression of essential factors in epidermis development, such as keratins, integrins and laminins. Furthermore, Nir binds to and controls the expression of p63 and limits H3K18ac at the p63 promoter. Corroborating the stratification defects, asymmetric cell divisions were virtually absent in Nir-deficient mice, suggesting that Nir is required for correct mitotic spindle orientation. In summary, our data define Nir as a key regulator of skin development.
Risso's dolphins plan foraging dives
Authors: Arranz Patricia , Benoit-Bird Kelly J. , Southall Brandon L. , Calambokidis John , Friedlaender Ari S. , Tyack Peter L. 
Published: March 2018

ABSTRACT
Humans remember the past and use that information to plan future actions. Lab experiments that test memory for the location of food show that animals have a similar capability to act in anticipation of future needs, but less work has been done on animals foraging in the wild. We hypothesized that planning abilities are critical and common in breath-hold divers who adjust each dive to forage on prey varying in quality, location and predictability within constraints of limited oxygen availability. We equipped Risso's dolphins with sound-and-motion recording tags to reveal where they focus their attention through their externally observable echolocation and how they fine tune search strategies in response to expected and observed prey distribution. The information from the dolphins was integrated with synoptic prey data obtained from echosounders on an underwater vehicle. At the start of the dives, whales adjusted their echolocation inspection ranges in ways that suggest planning to forage at a particular depth. Once entering a productive prey layer, dolphins reduced their search range comparable to the scale of patches within the layer, suggesting that they were using echolocation to select prey within the patch. On ascent, their search range increased, indicating that they decided to stop foraging within that layer and started searching for prey in shallower layers. Information about prey, learned throughout the dive, was used to plan foraging in the next dive. Our results demonstrate that planning for future dives is modulated by spatial memory derived from multi-modal prey sampling (echoic, visual and capture) during earlier dives.
The NORSe: changing the way we communicate
Authors: Mehet J , Sanchez Franco LC , Gascon Conde I , Sanchez Campoy A , Thimmaiah R , Eldessouky A , Eldessouky A , Uzoigwe CE , Smith R 
Published: March 2018

Introduction Rapid, reliable and efficient communication in healthcare systems with finite resources promises to improve patient care. Telephone engagement has effectively monopolised the referral process in the acute setting. Hence, traditional inter-hospital referral networks are potentially time consuming, not expeditious and frustrating. There is often no comprehensive documented communication record or audit trail. Social media, however, suggest that instantaneous, secure and dependable exchanges of information can occur via alternative conduits, potentially transforming the acute clinical referral system. The National On-Call Referral System (NORSe) was established in 2010 as an alternative referral paradigm. We explore the literature evidence surrounding the clinical impact of the NORSe referral system and analogous models. Early evidence suggests that NORSe may minimise delays in obtaining specialist advice and management, particularly in the acute setting. It enables the specialist to receive and address a large number of fact intense referrals that would otherwise be unpalatable and unmanageable. We summarise recent developments with the NORSe and give an overview of its clinical applications and links with clinical governance. NORSe and similar models promise to change the way we communicate as doctors, making the process more efficient, with a robust audit trail facilitating service appraisal and training.
Variant Linkage Analysis Using de Novo Transcriptome Sequencing Identifies a Conserved Phosphine Resistance Gene in Insects
Authors: Schlipalius David I , Tuck Andrew G , Jagadeesan Rajeswaran , Nguyen Tam , Kaur Ramandeep , Subramanian Sabtharishi , Barrero Roberto , Nayak Manoj , Ebert Paul R 
Published: March 2018

Abstract
Next-generation sequencing methods enable identification of the genetic basis of traits in species that have no prior genomic information available. The combination of next-generation sequencing, variant analysis, and linkage is a powerful way of identifying candidate genes for a trait of interest. Here, we used a comparative transcriptomics [RNA sequencing (RNAseq)] and genetic linkage analysis approach to identify the rph1 gene. rph1 variants are responsible for resistance to the fumigant phosphine (PH3) that is used to control insect pests of stored grain. In each of the four major species of pest insect of grain we have investigated, there are two major resistance genes, rph1 and rph2, which interact synergistically to produce strongly phosphine-resistant insects. Using RNAseq and genetic linkage analyses, we identified candidate resistance (rph1) genes in phosphine-resistant strains of three species: Rhyzopertha dominica (129 candidates), Sitophilus oryzae (206 candidates), and Cryptolestes ferrugineus (645 candidates). We then compared these candidate genes to 17 candidate resistance genes previously mapped in Tribolium castaneum and found only one orthologous gene, a cytochrome b5 fatty acid desaturase (Cyt-b5-r), to be associated with the rph1 locus in all four species. This gene had either missense amino acid substitutions and/or insertion/deletions/frameshift variants in each of 18 phosphine-resistant strains that were not observed in the susceptible strains of the four species. We propose a model of phosphine action and resistance in which phosphine induces lipid peroxidation through reactive oxygen species generated by dihydrolipoamide dehydrogenase, whereas disruption of Cyt-b5-r in resistant insects decreases the polyunsaturated fatty acid content of membranes, thereby limiting the potential for lipid peroxidation.