bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal email-based electrocardiogram interpretation curriculum for paediatric residents
Authors: Van Der Bosch Margaret , Soohoo Megan 
Published: November 2024

AbstractBackground:Electrocardiograms are frequently obtained in infants and children. Training specific to paediatric electrocardiogram interpretation is necessary given that cardiac physiology and electrocardiogram findings in children are different than adults and change throughout infancy and childhood. Distributed practice may be an effective method to improve paediatric residency electrocardiogram education efforts.Methods:A pre-survey was administered to paediatric and internal medicine/paediatrics residents to ascertain baseline comfort with electrocardiogram interpretation. Subsequently, residents were emailed a clinical vignette with an associated electrocardiogram and multiple-choice question 1–2 times monthly. After submitting their answer, residents were taken to a webpage explaining key concepts explored in the clinical vignette. After 6 and 12 months, a survey was administered asking residents to again rate their confidence in the same electrocardiogram interpretation skills.Results:The longitudinal email-based curriculum increased exposure to electrocardiogram training. Six months of participation in the curriculum correlated with significant increases in confidence in electrocardiogram interpretation skills. While there was no further increase in confidence seen at 12 months, the improvement seen at 6 months was durable. Participation in the curriculum most significantly correlated with changes in confidence in ability to utilise a stepwise approach for electrocardiogram interpretation.Conclusions:The curriculum resulted in durable improvement in confidence in electrocardiogram interpretation skills for paediatric residents at our centre, suggesting that email-based distributive practice can be an effective method for skill and knowledge improvement for complex educational topics.
Precision of artificial intelligence in paediatric cardiology multimodal image interpretation
Authors: Gritti Michael N. , Prajapati Rahil , Yissar Dolev , Morgan Conall T. 
Published: November 2024

AbstractMultimodal imaging is crucial for diagnosis and treatment in paediatric cardiology. However, the proficiency of artificial intelligence chatbots, like ChatGPT-4, in interpreting these images has not been assessed. This cross-sectional study evaluates the precision of ChatGPT-4 in interpreting multimodal images for paediatric cardiology knowledge assessment, including echocardiograms, angiograms, X-rays, and electrocardiograms. One hundred multiple-choice questions with accompanying images from the textbook Pediatric Cardiology Board Review were randomly selected. The chatbot was prompted to answer these questions with and without the accompanying images. Statistical analysis was done using X2, Fisher’s exact, and McNemar tests. Results showed that ChatGPT-4 answered 41% of questions with images correctly, performing best on those with electrocardiograms (54%) and worst on those with angiograms (29%). Without the images, ChatGPT-4’s performance was similar at 37% (difference = 4%, 95% confidence interval (CI) –9.4% to 17.2%, p = 0.56). The chatbot performed significantly better when provided the image of an electrocardiogram than without (difference = 18, 95% CI 4.0% to 31.9%, p < 0.04). In cases of incorrect answers, ChatGPT-4 was more inconsistent with an image than without (difference = 21%, 95% CI 3.5% to 36.9%, p < 0.02). In conclusion, ChatGPT-4 performed poorly in answering image-based multiple-choice questions in paediatric cardiology. Its accuracy in answering questions with images was similar to without, indicating limited multimodal image interpretation capabilities. Substantial training is required before clinical integration can be considered. Further research is needed to assess the clinical reasoning skills and progression of ChatGPT in paediatric cardiology for clinical and academic utility.
Post-COVID condition: a focus on psychiatric symptoms and diagnoses in patients with cognitive complaints
Authors: Cerioli Matteo , Giacovelli Luca , Nostro Chiara , Larini Luca , Castiglioni Michele , Scarpa Carolina , Cassina Niccolò , Nicotra Alessia , Maestri Giorgia , Cucumo Valentina , Masserini Federico , Pomati Simone , Cirnigliaro Giovanna , Pantoni Leonardo , Dell’Osso Bernardo 
Published: November 2024

AbstractObjectiveCognitive and psychiatric symptoms are frequently reported after SARS-CoV-2 infection, but their interplay has been only partially explored. We investigated frequency and severity of psychiatric symptoms in patients with persistent cognitive complaints after COVID-19.MethodsWe conducted a cross-sectional study. Neurologists assessed 101 patients reporting cognitive symptoms after COVID-19. Patients were invited to fill a screening battery with self-reported psychometric scales (Depression Anxiety Stress Scales-21, Impact of Event Scale-Revised, Insomnia Severity Index). Patients scoring above validated cut-offs in ≥1 scale were referred to psychiatrists who administered the Mini-International Neuropsychiatric Interview (M.I.N.I.), Hamilton Anxiety (HAM-A), and Hamilton Depression (HAM-D) rating scales and asked to complete the Personality Inventory for DSM-5-Brief Form (PID-5-BF).ResultsOut of the 57 referred patients, 38 (64.4%) accepted to undergo the psychiatric examination. Among these, 18 (47.4%) were diagnosed with adjustment disorder (23.7%), anxiety disorder (10.5%), major depressive disorder (7.9%), and post-traumatic stress disorder (2.6%). Pharmacologic treatment before post-COVID condition (present in 12 patients, 31.6%) was associated with a score above cut-off on the HAM-A and HAM-D scales. A longer duration of untreated psychiatric illness after COVID-19 was associated with worse scores on the same scales. Patients with a higher PID-5-BF total score had a higher probability of receiving a psychiatric diagnosis.ConclusionAlmost half of patients with post-COVID-19 conditions reporting cognitive symptoms were found to suffer from a psychiatric condition after psychiatric evaluation. The application of a psychiatric screening in a population suffering from long-term effects of COVID-19 can lead to early diagnosis and timely treatment.
Estimating food consumption, micronutrient intake and the contribution of large-scale food fortification to micronutrient adequacy in Tanzania
Authors: Goto Rie , Mlambo Liberty , Segovia De La Revilla Lucia , Swai Aleswa , Mshida Hoyce , Amos Alex , Karugendo Emilian , Osman Gareth , Tang Kevin , Codd Thomas , Chagumaira Christopher , Ferguson Elaine L , Ander E Louise , Jumbe Theresia , Masumo Ray , Dary Omar , Yourkavitch Jennifer , Pedersen Sarah , Leyna Germana H , Woldt Monica , Joy Edward JM 
Published: November 2024

Abstract

Objective:
To assess the potential contribution of large-scale food fortification (LSFF) towards meeting dietary micronutrient requirements in Tanzania.

Design:
We used household food consumption data from the National Panel Survey 2014–15 to estimate fortifiable food vehicle coverage and consumption (standardised using the adult female equivalent approach) and the prevalence at risk of inadequate apparent intake of five micronutrients included in Tanzania’s fortification legislation. We modelled four LSFF scenarios: no fortification, status quo (i.e. compliance with current fortification contents) and full fortification with and without maize flour fortification.

Setting:
Tanzania.

Participants:
A nationally representative sample of 3290 Tanzanian households.

Results:
The coverage of edible oils and maize and wheat flours (including products of wheat flour and oil such as bread and cakes) was high, with 91 percent, 88 percent and 53 percent of households consuming these commodities, respectively. We estimated that vitamin A-fortified oil could reduce the prevalence of inadequate apparent intake of vitamin A (retinol activity equivalent) from 92 percent without LSFF to 80 percent with LSFF at current fortification levels. Low industry LSFF compliance of flour fortification limits the contribution of other micronutrients, but a hypothetical full fortification scenario shows that LSFF of cereal flours could substantially reduce the prevalence at risk of inadequate intakes of iron, zinc, folate and vitamin B12.

Conclusions:
The current Tanzania LSFF programme likely contributes to reducing vitamin A inadequacy. Policies that support increased compliance could improve the supply of multiple nutrients, but the prominence of small-scale maize mills restricts this theoretical benefit.
Surveying, mapping, and translating: how property rights were created in Shanghai, 1860–1900?
Authors: Luo Fusheng 
Published: November 2024

Abstract
From 1860 to 1900, a modern system of property rights emerged in the International Settlement in Shanghai. This paper examines the largely overlooked process by which the Shanghai Municipal Council (SMC) brought about a system of well-functioning property rights through land surveys, mapping, and assessments. These methods worked hand-in-hand with road planning and construction in facilitating the expansion of the International Settlement to the Chinese-controlled area. Colonial officials, merchants, and Chinese intellectuals worked collectively and sometimes separately to generate knowledge about land and property by translating terms in the Chinese tradition. It argues that the efforts in institution-building and translation helped normalize the definition of property rights as things exclusively owned, strengthening the SMC's control over the land in Shanghai. These processes illuminate the relationship between empire-making and property rights by showing how property rights emerged and functioned in a semi-colonial context where multiple foreign authorities coexisted with the local government. The relatively secure system of property rights, which both foreign and Chinese merchants exploited, formed the foundation of a prosperous Shanghai in the twentieth century.
Can participatory democracy become “inclusive”? Class, mobilization and voice in participatory institutions
Authors: García-Espín Patricia 
Published: November 2024

Abstract
This article discusses reproductionist perspectives that assume there is little local participatory institutions can do to address the underrepresentation and the domination of some social groups. While there is also empirical basis to be skeptical, the evidence suggests that, occasionally, the reproduction of class inequalities can be counteracted. This encourages us to consider the conditions that favor greater participation of working-class, economically and culturally disadvantaged people. Comparing evidence from various studies in a range of countries, the article argues that certain contextual factors and inclusion tools produce higher rates of mobilization and more egalitarian deliberations. Specifically, the article focuses on the effects of three conditions: a) special mobilization efforts; b) design choices and inclusion tools; and c) the broadening of the political subject through cultural mobilization. As well as reflecting on the shortcomings of these factors, a new research agenda for social equality in participation is also proposed.
The Role of Sibling Patterns in the Educational Attainment of Hungarian Twins
Authors: Pári András , Engler Ágnes 
Published: November 2024

AbstractStudies concerning twins with a sociological focus are scarce in Hungary as well as international research, although the number of twin births has increased dramatically worldwide. The raising and education of twins are tasks demanding special attention from both the family and institutions. In our study we examine these aspects, looking back from adulthood, using the narrow scope of the available data from research based on the ‘Hungarostudy 2021’ database (N total: 7000; n twins: 106). Our results, corresponding to the hypotheses of educational sociology, demonstrate how the relationships between family size and school career and increasing number of siblings reduces the chances of high educational attainment. A regression analysis confirmed that both the number of siblings and a later position in the birth order reduces the chance of obtaining a higher education. For the second child in a family, the chance of earning a university degree is reduced to to 0.743. The role of a large family concerning higher education showed a stronger relationship in the case of twins compared to nontwins. For twins, the sibling pattern has a decisive effect in educational attainment. Twins themselves have a 1.449 times higher chance of obtaining a higher education compared to nontwins (p = 0.101), and fraternal twins have half (0.517) the chance of obtaining a higher education compared to identical twins; but both results are not significant (p = 0.156).
Past Groundwater Drought in the North American Cordillera
Authors: Hunter S. C. , Allen D. M. , Kohfeld K. E. 
Published: November 2024

AbstractGroundwater level records in North America are relatively short (<60 years), preventing long‐term analysis of historical changes in groundwater levels associated with drought. In this study, tree ring widths are used to reconstruct groundwater levels in three regions in the North American Cordillera: Central British Columbia (BC), Canada, the Southern Interior Region of BC, and the San Luis Valley in Colorado, USA. Periods with severe drought conditions, identified using regime shift and threshold analyses were: 1890–1900 and 1950–1970 in Colorado, around 1920–1940 in the BC Interior, and 1935–1945 in Central BC. The groundwater level reconstructions are correlated with several climate indices and have similar regime shifts as identified in streamflow and drought records. The groundwater level reconstructions are strongly related to winter snowpack, suggesting that the observed trend of declining snowpack in recent years may lead to declining groundwater availability in these regions.
The Vertical Structure of Turbulence Kinetic Energy Near the Arctic Sea‐Ice Surface
Authors: Peng Shijie , Yang Qinghua , Shupe Matthew D. , Han Bo , Chen Dake , Liu Changwei 
Published: November 2024

AbstractAtmospheric turbulence over the Arctic sea‐ice surface has been understudied due to the lack of observational data. In this study, we focus on the turbulence kinetic energy (TKE) over sea ice and distinguish its two different vertical structures, the “Surface” type and the “Elevated” type, using observations during the Multidisciplinary drifting Observatory for the Study of Arctic Climate expedition (MOSAiC). The “Surface” type has the maximum TKE near the surface (at 2 m), while the “Elevated” type has the maximum TKE at a higher level (6 m). The TKE budget analysis indicates that the “Elevated” type is caused by the increased shear production of TKE at 6 m. In addition, spectral analysis reveals that the contribution to TKE by horizontal large eddies is enhanced in the “Elevated” type. Finally, how the vertical structure of TKE affects the parameterization of turbulent momentum flux is discussed.
Major Artifacts in ERA5 2‐m Air Temperature Trends Over Antarctica Prior to and During the Modern Satellite Era
Authors: Bromwich David H. , Ensign Alexandra , Wang Sheng‐Hung , Zou Xun 
Published: November 2024

AbstractGlobal reanalyzes are widely used for investigations of Antarctic climate variability and change. The European Centre for Medium‐Range Weather Forecasts 5th generation reanalysis (ERA5) is well regarded and spans 1940 to today. We investigate whether ERA5 reliably represents the 2‐m air temperature trends across the 1940–2022 (83 years) period at seasonal and annual time scales. We compare ERA5 temperatures with an observation‐based temperature reconstruction for Antarctica (RECON) that has monthly resolution for 1958–2022, the period of reliable observational availability. Results for individual stations are also examined. ERA5 anomalously warms Antarctica in relation RECON especially for the period prior to 1979 when satellite observations over the Southern Ocean were sparse. Trend hotspots that are shown to be artifacts are found at three locations and are present until today. The results demonstrate that ERA5 temperature trends can be questionable even today, but variability is well captured after 1979.
On the Implications of Ground‐Based High‐Definition Imaging of Io's Surface
Authors: Schmidt C. A. 
Published: November 2024

AbstractThe capability to observe temporal changes on Io's surface at optical wavelengths has recently been demonstrated by Conrad et al. (2024, https://doi.org/10.1029/2024GL108609) using new instrumentation at the Large Binocular Telescope. Monitoring of Io's surface morphology would be impactful since preexisting metrics of the degree, location and composition of Io's plume activities are severely limited. Relationships with external data sets appear especially fruitful. Comparisons with spatially resolved data on gas distributions and thermal hots spots would better characterize composition and chemistry in Io's volcanic plumes. Comparisons with measurements remote from Io are posed to advance our understanding of atmospheric escape and how eruptions connect to transient enhancements at disparate size and time scales in the extended neutral clouds and plasma torus.
Targeting G-quadruplex by TMPyP4 for inhibition of colorectal cancer through cell cycle arrest and boosting anti-tumor immunity
Authors: Li Peisi , Zhou Dawang , Xie Yumo , Yuan Ze , Huang Mingzhe , Xu Gaopo , Huang Junfeng , Zhuang Zhuokai , Luo Yanxin , Yu Huichuan , Wang Xiaolin 
Published: November 2024

AbstractG-quadruplex (G4) is a noncanonical DNA secondary structure known to induce DNA damage and regulate the expression of immune-related genes. We aim to exploit the G4 folding as a treatment strategy to trigger anti-tumor immune response. In this study, we observe that the abundant genomic G4 in epithelial cells coexists with increased infiltration of CD8+ T cells in colorectal cancer tissue. Furthermore, our data substantiate the inhibitory effect of the G4 ligand TMPyP4 on cancer progression while concurrently stimulating anti-tumor immunity. Mechanistically, TMPyP4 impedes cancer cell proliferation and induces G2/M cell cycle arrest. Additionally, in vivo experiments demonstrate that TMPyP4 enhances the anti-tumor immune response by triggering DNA damage and activating the cGAS-STING pathway, which fosters CD8+ T cell activation and dendritic cell maturation. Importantly, the combined treatment of TMPyP4 and anti-PD1 exhibits a synergistic therapeutic effect on colorectal cancer. In summary, our findings underscore the potential of the G4 ligand TMPyP4 as a dual strategy to target colorectal cancer: inhibiting cancer progression and augmenting anti-tumor immunity through the activation of cGAS-STING pathway.
Single-cell landscape identified SERPINB9 as a key player contributing to stemness and metastasis in non-seminomas
Authors: Bian Zhouliang , Chen Biying , Shi Guohai , Yuan Haihua , Zhou Yue , Jiang Bin , Li Long , Su Hengchuan , Zhang Yanjie 
Published: November 2024

AbstractEmbryonal carcinoma (EC), characterized by a high degree of stemness similar to that of embryonic stem cells, is the most malignant subtype within non-seminomatous testicular germ cell tumors (TGCTs). However, the mechanisms underlying its malignancy remain unknown. In this study, we employed single-cell RNA sequencing to analyze four non-seminoma samples. Our differential expression analysis revealed high expression of SERPINB9 in metastatic EC cells. We conducted in vitro experiments to further investigate SERPINB9’s role in the progression of EC. Functionally, the knockdown of SERPINB9 in NCCIT and NTERA-2 leads to a diminished migratory capability and decreased cis-platin resistance, as demonstrated by Transwell migration assay and drug sensitivity assay. Moreover, embryoid bodies showed reduced size and lower OCT4 expression, alongside heightened expression of differentiation markers AFP, ACTA2, and CD57 in shSERPINB9 cells. In vivo, the role of SERPINB9 in maintaining cancer stemness was validated by the limiting dilution assay. Mechanistically, Bulk RNA-seq further showed downregulation of ERK1/2 signaling and WNT signaling pathways with concomitant upregulation of differentiation pathways subsequent to SERPINB9 knockdown. Additionally, the analysis indicated increased levels of cytokines linked to tertiary lymphoid structures (TLS), such as IL6, IL11, IL15, CCL2, CCL5, and CXCL13 in shSERPINB9 cells, which were further validated by ELISA. Our research indicates that SERPINB9 plays a key role in driving tumor progression by enhancing tumor stemness and suppressing TLS. This study stands as the first to elucidate the molecular signature of non-seminomas at a single-cell level, presenting a wealth of promising targets with substantial potential for informing the development of future therapeutic interventions.
Revealing single-neuron and network-activity interaction by combining high-density microelectrode array and optogenetics
Authors: Kobayashi Toki , Shimba Kenta , Narumi Taiyo , Asahina Takahiro , Kotani Kiyoshi , Jimbo Yasuhiko 
Published: November 2024

AbstractThe synchronous activity of neuronal networks is considered crucial for brain function. However, the interaction between single-neuron activity and network-wide activity remains poorly understood. This study explored this interaction within cultured networks of rat cortical neurons. Employing a combination of high-density microelectrode array recording and optogenetic stimulation, we established an experimental setup enabling simultaneous recording and stimulation at a precise single-neuron level that can be scaled to the level of the whole network. Leveraging our system, we identified a network burst-dependent response change in single neurons, providing a possible mechanism for the network-burst-dependent loss of information within the network and consequent cognitive impairment during epileptic seizures. Additionally, we directly recorded a leader neuron initiating a spontaneous network burst and characterized its firing properties, indicating that the bursting activity of hub neurons in the brain can initiate network-wide activity. Our study offers valuable insights into brain networks characterized by a combination of bottom-up self-organization and top-down regulation.
Nanocarrier mediated delivery of insecticides into tarsi enhances stink bug mortality
Authors: Sharma Sandeep , Perring Thomas M. , Jeon Su-Ji , Huang Huazhang , Xu Wen , Islamovic Emir , Sharma Bhaskar , Giraldo Ysabel Milton , Giraldo Juan Pablo 
Published: November 2024

AbstractCurrent delivery practices for insecticide active ingredients are inefficient with only a fraction reaching their intended target. Herein, we developed carbon dot based nanocarriers with molecular baskets (γ-cyclodextrin) that enhance the delivery of active ingredients into insects (southern green stink bugs, Nezara viridula L.) via their tarsal pores. Nezara viridula feeds on leguminous plants worldwide and is a primary pest of soybeans. After two days of exposure, most of the nanocarriers and their active ingredient cargo (>85%) remained on the soybean leaf surface, rendering them available to the insects. The nanocarriers enter stink bugs through their tarsi, enhancing the delivery of a fluorescent chemical cargo by 2.6 times. The insecticide active ingredient nanoformulation (10 ppm) was 25% more effective in controlling the stink bugs than the active ingredient alone. Styletectomy experiments indicated that the improved active ingredient efficacy was due to the nanoformulation entering through the insect tarsal pores, consistent with fluorescent chemical cargo assays. This new nanopesticide approach offers efficient active ingredient delivery and improved integrated pest management for a more sustainable agriculture.