bluuebunny/crossref_metadata_2025_split huggingface dataset:
circMAN1A2 could serve as a novel serum biomarker for malignant tumors
Authors: Fan Chun‐Mei , Wang Jin‐Peng , Tang Yan‐Yan , Zhao Jin , He Shu‐Yi , Xiong Fang , Guo Can , Xiang Bo , Zhou Ming , Li Xiao‐Ling , Li Yong , Li Gui‐Yuan , Xiong Wei , Zeng Zhao‐Yang 
Published: May 2019

AbstractNovel diagnostic and prognostic biomarkers of cancers are needed to improve precision medicine. Circular RNAs act as important regulators in cancers at the transcriptional and posttranscriptional levels. The circular RNA circMAN1A2 is highly expressed in nasopharyngeal carcinoma according to our previous RNA sequencing data; however, the expression and functions of circMAN1A2 in cancers are still obscure. Therefore, in this study, we evaluated the expression of circMAN1A2 in the sera of patients with nasopharyngeal carcinoma and other malignant tumors and analyzed its correlations with clinical features and diagnostic values. The expression levels of circMAN1A2 were detected by quantitative real‐time PCR, and the correlations of clinical features with circMAN1A2 expression were analyzed by χ2 tests. Receiver operating characteristic curves were used to evaluate the clinical applications of circMAN1A2. The results showed that circMAN1A2 was upregulated in nasopharyngeal carcinoma, oral cancer, thyroid cancer, ovarian cancer, and lung cancer, with areas under the curves of 0.911, 0.779, 0.734, 0.694, and 0.645, respectively, indicating the good diagnostic value of circMAN1A2. Overall, our findings suggested that circMAN1A2 could be a serum biomarker for malignant tumors, providing important insights into diagnostic approaches for malignant tumors. Further studies are needed to elucidate the mechanisms of circMAN1A2 in the pathogenesis of cancer.
The association of allergic sensitization patterns in early childhood with disease manifestations and immunological reactivity at 10 years of age
Authors: Schulten Véronique , Frazier April , Calatroni Agustin , Kattan Meyer , Bacharier Leonard B. , O’Connor George T. , Sandel Megan T. , Wood Robert A. , Wheatley Lisa M. , Togias Alkis , Visness Cynthia M , Dresen Amy , Gern James E. , Sette Alessandro 
Published: May 2019

AbstractBackgroundAllergy to German cockroach (CR) is common in urban environments and is an important allergen in children with asthma.ObjectiveWe hypothesize that the evolution of allergic sensitization and clinical disease is associated with distinct patterns of allergen‐specific T cell reactivity. To test this hypothesis, a subset of high‐risk inner‐city children participating in the URECA (Urban Environment and Childhood Asthma) birth cohort were selected to evaluate CR‐specific T cell reactivity from three distinct groups based on acquisition of aeroallergen sensitivity from ages 2 to 10: low atopy with minimal to no sensitivity (n = 26), early‐onset allergic sensitization (n = 25) and late‐onset allergic sensitization (n = 25).MethodsUsing pools of previously identified CR‐derived T cell epitopes, we characterized the allergen‐specific T cell response in these 76 subjects from blood samples obtained at age 10. CR‐specific production of IL‐5, IFNγ and IL‐10 was measured by ELISPOT following two‐week in vitro culture with CR extract.ResultsT cell responses were significantly higher in the early‐onset atopy group compared to low atopy (P = 0.01), and a trend for higher cytokine production in the late onset compared to the low atopy cohort was also observed (P = 0.06). T cell responses were similar between early‐ and late‐onset cohorts. Furthermore, a comparison of T cell reactivity between asthmatic and non‐asthmatic individuals revealed significantly higher cytokine production in asthmatics compared to non‐asthmatics (P = 0.02) within both the CR‐allergic and non‐allergic cohorts.Conclusions and clinical relevanceIn conclusion, the present study reports that higher T cell reactivity is associated with allergen sensitization and asthma. Interestingly, no significant difference in T cell reactivity was observed in allergic children with early‐onset versus late‐onset atopy.
Comparing short dental implant and standard dental implant in terms of marginal bone level changes: A systematic review and meta‐analysis of randomized controlled trials
Authors: Bitaraf Tahereh , Keshtkar Abbasali , Rokn Amir Reza , Monzavi Abbas , Geramy Allahyar , Hashemi Kazem 
Published: May 2019

AbstractPurposeTo compare short implants (SH; 4‐8 mm) to standard implants (ST; longer than 8 mm) in edentulous jaws, evaluating pri‐implant marginal bone levels (MBLs) changes, implant failures (IFs), complications, and prosthesis failures (PFs).Materials and MethodsElectronic searches were conducted through the PubMed, Web of Science, EMBASE, Scopus, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov to locate all randomized controlled trials (RCTs) comparing SH to ST. Meta‐analysis procedures were performed on the weighted mean difference (WMD) and standardized mean difference (SMD) of MBLs using Stata.ResultsTwenty‐three articles were included in this review. The WMD of MBLs when comparing SH to ST in both jaws up to 1‐year follow‐up was statistically significant preferring SH (WMD: −0.09 [CI: −0.12, −0.06], I2: 67.0%). The efficacy of SH vs ST on SMD of MBLs was moderate (SMD: −0.43 [CI: −0.57, −0.28], I2: 55.7%). There were no significant differences in IF (RR: 0.75 [0.44,1.27]) and PF (RR: 0.58 (0.22,1.581), and significantly higher biological complications (RR: 0.25 [0.15, 0.40]) for SH was observed compared to the ST in both jaws up to 1‐year follow‐up.ConclusionsSH and ST implants showed the comparable outcomes except biological complication preferring SH. Future systematic review and meta‐analysis with longer and larger RCTs are required to confirm the present outcomes.
Immediate implant placement combined with maxillary sinus floor elevation utilizing the transalveolar approach and nonsubmerged healing for failing teeth in the maxillary molar area: A randomized controlled trial clinical study with one‐year follow‐up
Authors: Liu Hanqing , Liu Renzhang , Wang Mingzhen , Yang Jianjun 
Published: May 2019

AbstractBackgroundIn previous studies, immediate implant placement in molar sites has been widely applied.PurposeTo study the clinical effect and feasibility of immediate implant placement combined with maxillary sinus floor elevation utilizing the transalveolar approach and nonsubmerged healing for failing teeth in the maxillary molar area.Material and MethodsPatients who required implantation surgry to replace a failing tooth in the maxilla molar region were selected. Patients were randomized into two groups: immediate implant placement combined with maxillary sinus floor elevation utilizing the transalveolar approach and nonsubmerged healing (test group) or delayed implant placement combined with maxillary sinus floor elevation utilizing the transalveolar approach and nonsubmerged healing (control group). The outcome criteria were the success rates of implants, Cone Beam Computer Tomography (CBCT) data and results of the subjective satisfaction survey performed with a visual analog scale (VAS).ResultsAll implants had good initial stability after implantation. The survival rate of implants was 100% at 1‐year follow‐up. At the time of permanent restoration, the differences in average horizontal shrinkage of alveolar bone (W1) on the buccal side between the test group (0.65 ± 0.12 mm) and the control group (1.23 ± 0.32 mm) were statistically significant (P < .0001); however, no statistically significant difference (P = .515) was observed on the palatal side (0.3 ± 0.10 mm vs 0.28 ± 0.08 mm). The difference in vertical resorption of alveolar bone (H1) on the buccal side between the test group (0.60 ± 0.18 mm) and the control group (1.53 ± 0.19 mm) was statistically significant (P < .0001), but no statistically significant difference (P = .190) in the reduction of palatal alveolar bone (0.24 ± 0.12 mm vs 0.29 ± 0.13 mm) was observed. After 1‐year loading, no statistically significant difference (P > .05) in vertical or horizontal changes (W2, H2) were identified in the test group or control group. Patient satisfaction in both groups was similar (8.36 ± 1.01 vs 8.14 ± 1.35), and the difference between groups was not statistically significant (P = .638).ConclusionImmediate implant placement combined with maxillary sinus floor elevation utilizing the transalveolar approach and nonsubmerged healing is feasible for the maxillary molar area, and the clinical effect is satisfactory.
Usefulness of ENT clinical examinations in hospitalised patients chronically addicted to alcohol and tobacco to detect head and neck squamous cell carcinomas. A retrospective study of 159 patients
Authors: Baert Maxime , Pascual Caroline , Biet‐Hornstein Aurélie , Nadjingar Ritoungarte , Haremza Céline , Page Cyril 
Published: May 2019

AbstractObjectiveTo determine whether an ENT clinical screening examination done on all patients chronically addicted to alcohol or tobacco would allow the early diagnosis of cancer of the upper aerodigestive tract.Study DesignCase series with chart review.SettingNon‐university general hospital.Subjects and methodsA total of 159 patients presenting chronic addiction to alcohol or tobacco hospitalized in an addiction center or a comprehensive medical clinic were included in this study covering the period 2011‐2016. All patients systematically benefitted from an ENT clinical examination to detect mucous membrane lesions. The lesions were categorized as: cancerous, pre‐cancerous, or benign. The patients were divided into two groups for comparison: 1) patients with symptoms (dysphagia, dysphonia, dyspnea upon inhalation, cervico‐facial pain, secondary otalgia, pharyngeal discomfort unrelated to deglutition, presence of a cervical swelling, or weight loss), and 2) asymptomatic patients.ResultsThe ENT exam was normal in 121 patients (76.1%). Fifty‐two patients (32.7%) had at least one symptom. The ENT exam allowed us to detect a benign lesion in 11 patients, a pre‐cancerous lesion in 11 patients, and a cancer in 16 (13.22%) patients. All patients with cancer had at least one symptom.ConclusionAn ENT clinical screening examination done on patients chronically addicted to alcohol or tobacco can allow early diagnosis of cancer, particularly in patients with at least one symptom.
Outcomes for 18 to 25‐year‐olds with borderline personality disorder in a dedicated young adult only DBT programme compared to a general adult DBT programme for all ages 18+
Authors: Lyng Jim , Swales Michaela A. , Hastings Richard P. , Millar Tracy , Duffy Daniel J. 
Published: May 2019

AimTargeting young adults with borderline personality disorder (BPD) for treatment may carry significant social and clinical benefits. We aimed to evaluate a community‐based Dialectical Behaviour Therapy (DBT) programme delivered exclusively to young adults with BPD.MethodsWe describe a naturally occurring non‐equivalent, quasi‐experimental comparison of outcomes for young adults (18‐25 years) with BPD following 1 year of treatment in either a young adult only DBT programme or a general adult DBT programme (18+ years). Twenty‐four young adults enrolled in a community‐based young adult DBT programme open only to 18‐ to 25‐year‐olds with BPD. Another 13 young adults, also 18‐25 years, enrolled in a general adult DBT programme open to all ages above 18 years. Both treatment conditions offered all modes of standard DBT for 1 year. Participants completed a battery of self‐report measures on mental health symptoms at baseline and again at treatment completion after 1 year. Discharge rates at 2 years post‐treatment completion were also recorded.ResultsBetter outcomes were found on borderline symptom severity and general psychopathology among completers of young adult DBT, with a large effect size for treatment condition as well as greater clinically significant change. Discharge rates from mental health services 24 months later were also higher for completers of young adult DBT.ConclusionsThere may be advantages in delivering DBT to young adults in an age‐specific programme, possibly due to group cohesion. Methodological limitations apply, such as small sample size and non‐randomization. Further controlled research is needed.
Juvenile convict cichlids shoaling decisions in relation to shoal size and age
Authors: Marlin Theresa , Snekser Jennifer L. , Leese Joseph M. 
Published: May 2019

AbstractMany animals form groups and socialize in response to evolutionary pressures such as predation, food availability, and mate acquisition. Evidence of social choice based on various phenotypic characters (Group Phenotypic Composition [GPC]) has been observed in several animal species. In addition to the physical characteristics of the social group, it is also interesting to consider how decisions of who to socialize with might be expected to change for an individual over time. Younger individuals with limited life experience may discriminate differently between social groups than older conspecifics who have had the opportunity to learn and who may be faced with different ecological or environmental pressures. Here, we used a traditional two‐choice design to explore the shoaling behavior of juvenile convict cichlids and determine whether the number of fish and/or the size/life stage of the individuals within a shoal influenced social choices. We found that juvenile convict cichlids spent more time shoaling with similarly sized juvenile individuals and also preferred to shoal with larger shoals, but not when shoals were comprised of adult fish. The size of the individuals in a shoal was a more influential factor than the size of the shoal itself. Size of individual juveniles was correlated with tendency to visit shoals, but was not correlated with overall time spent shoaling, regardless of shoal composition. As juveniles, convict cichlids can make discriminatory choices that are influenced by specific aspects of shoal composition.
Ischaemic events are rare, and the prevalence of hypertension is not high in Japanese adults with haemophilia: First multicentre study in Asia
Authors: Nagao Azusa , Suzuki Nobuaki , Takedani Hideyuki , Yamasaki Naoya , Chikasawa Yushi , Sawada Akihiro , Kanematsu Takeshi , Nojima Masanori , Higasa Satoshi , Amano Kagehiro , Fukutake Katsuyuki , Fujii Teruhisa , Matsushita Tadashi , Suzuki Takashi 
Published: May 2019

IntroductionWith the increasing life expectancy of patients with haemophilia (PWH), the number of PWH with age‐related comorbidities, such as ischaemic events, is increasing.AimWe conducted this multicentre observational study to identify the risk factors for major ischaemic events in PWH.MethodsThis study was the first multicentre observational study, conducted with the participation of five haemophilia treatment centres in Japan, conducted in ≥30‐year‐old adult PWH. The latest data recorded in the medical charts between 1 January and 31 December 2016 were reviewed. Healthcare data collected from the National Health and Nutrition Survey were used as the control data.ResultsData of a total of 711 patients were collected. Only two PWH (0.3%) had a history of ischaemic events. Age‐adjusted analysis indicated that the prevalence of hypertension defined as a blood pressure of 140/90 mm Hg or over was similar in the PWH to that in the males of the general population. However, when hypertension was defined more strictly (≥130/85 mm Hg), the prevalence was significantly lower in PWH than in the general male population. The hypertension in PWH was associated with the age, BMI, CKD, HIV infection and inhibitors. In particular, the odds ratio for the presence of inhibitors was high (odds ratio = 7.529).ConclusionWhether the present results can be attributed to Japanese ethnicity or to the presence of haemophilia per se remains uncertain. We propose to initiate a prospective study for further investigation.
Body temperature responses of Great Tits Parus major to handling in the cold
Authors: Andreasson Fredrik , Nord Andreas , Nilsson Jan‐Åke 
Published: May 2019

Animals typically respond to stressful stimuli such as handling by increasing core body temperature. However, small birds in cold environments have been found to decrease body temperature (Tb) when handled over longer periods, although there are no data extending beyond the actual handling event in such birds. We therefore measured both the initial Tb decrease during ringing and standardized Tb sampling, and subsequent recovery of Tb after this handling protocol in wild Great Tits Parus major roosting in nestboxes in winter. Birds reduced their Tb by 2.3 °C during c. 4 min of handling. When birds were returned to their nestboxes after handling, Tb decreased by a further 1.9 °C over c. 2 min, reaching a Tb of 34.6 °C before taking 20 min to rewarm to 2.5 °C above their initial Tb. The Tb reduction during handling could be a consequence of increased heat loss rate from disrupted plumage insulation, whereas Tb reduction after handling might reflect reduced heat production. These are important factors to consider when handling small birds in the cold.
How effective is a powered toothbrush as compared to a manual toothbrush? A systematic review and meta‐analysis of single brushing exercises
Authors: Elkerbout Therese A. , Slot Dagmar E. , Rosema N. A. Martijn , Van der Weijden G. A. 
Published: May 2019

AbstractObjectivesIn adult participants, what is, following a single brushing exercise, the efficacy of a powered toothbrush (PTB) as compared to a manual toothbrush (MTB) on plaque removal?MethodsMEDLINE‐PubMed and Cochrane‐CENTRAL were searched from inception to February 2019. The inclusion criteria were (randomized) controlled clinical trials conducted in human subjects ≥18 years of age, in good general health and without periodontitis, orthodontic treatment, implants and/or removable prosthesis. Papers evaluating a PTB compared with a MTB in a single brushing exercise were included. When plaque scores were assessed according to the Quigley‐Hein plaque index (Q&HPI) or the Rustogi modified Navy plaque index (RMNPI). From the eligible studies, data were extracted. A meta‐analysis and subanalysis for brands and mode of action being oscillating‐rotating (OR) and side‐to‐side (SS) were performed when feasible.ResultsIndependent screening of 3450 unique papers resulted in 17 eligible publications presenting 36 comparisons. In total, 28 comparisons assessed toothbrushing efficacy according to the Q&HPI and eight comparisons used the RMNPI. Results showed a significant effect in favour of the PTB. The difference of Means (DiffM) was −0.14 (P < 0.001; 95%CI [−0.19; −0.09]) for the Q&HPI and −0.10 (P < 0.001; 95%CI [−0.14; −0.06]) for the RMNPI, respectively. The subanalysis on the OR mode of action showed a DiffM −0.16 (P < 0.001; 95%CI [−0.22, −0.10]) for the Q&HPI. For the SS mode of action using RMNPI, the DiffM showed −0.10 (P < 0.001; 95%CI [−0.15; −0.05]). The subanalysis for brands showed for the P&G OR PTB using the Q&HPI a DiffM of −0.15 (P < 0.001; 95%CI [−0.22; −0.08]) and the Colgate SS for RMNPI showed a DiffM of −0.15 (P < 0.001; 95%CI [−0.18; −0.12]).ConclusionThere is moderate certainty that the PTB was more effective than the MTB with respect to plaque removal following a single brushing exercise independent of the plaque index scale that was used.
Effect of ethylenediaminetetraacetic acid irrigation on immune‐inflammatory response in teeth submitted to regenerative endodontic therapy
Authors: Bracks I. V. , Espaladori M. C. , Barros P. , de Brito L. C. N. , Vieira L. Q. , Ribeiro Sobrinho A. P. 
Published: May 2019

AbstractAimTo analyse longitudinally the immune‐inflammatory response in teeth of mice that underwent a regenerative protocol with or without the use of ethylenediaminetetraacetic acid (EDTA) to irrigate the root canal system.MethodologyFirst maxillary molars of mice were devitalized using size 10 and 15 files. Teeth were divided into the following groups: Empty – the canals were left empty; Blood Clot (BC) – the canals were filled with a blood clot; and EDTA + Blood – the canals were irrigated with 0.06 mL of 17% EDTA for 1 min and filled with a blood clot. Access cavities were restored with Coltosol®. Animals were sacrificed at 7, 14 or 21 days after the operative procedures, and teeth were collected. RNA was extracted, mRNA expression of the cytokines IGF, NGF, IL‐1α, IL‐10, TGF and VEGF was assessed using real‐time PCR, and the anova Kruskal–Wallis test was used.ResultsIL‐1 mRNA expression was significantly higher in the EDTA + BC group than in the Empty and BC groups at the 7th and 14th days of evaluation (P < 0.05). IL‐10 mRNA expression was similar across the three groups at all time periods. TGF‐β mRNA expression in the EDTA + BC group was significantly higher on the 7th and 21st days than on the 14th (P < 0.05); at day 21, TGF‐β mRNA expression was similar between the BC and EDTA + BC groups but significantly higher than in the Empty group (P < 0.05). IGF mRNA expression was significantly higher in the EDTA + BC group than in the other groups at all time periods. VEGF mRNA expression remained unchanged throughout the experimental period in all groups (P > 0.05). NGF mRNA expression was similar amongst all groups at the 7th and 21st days (P > 0.05). At the 14th day, however, there was a significant increase in NGF mRNA expression in the EDTA + Blood group (P < 0.05) when compared with the expression in the other groups.ConclusionEDTA promoted increased expression of factors that have the potential to improve the outcome of regenerative endodontic treatment.
The global factor in neutral policy rates: Some implications for exchange rates, monetary policy, and policy coordination
Authors: Clarida Richard 
Published: May 2019

AbstractThis paper highlights some of the theoretical and practical implications for monetary policy and exchange rates that derive specifically from the presence of a global general equilibrium factor embedded in neutral real policy rates in open economies. Using a standard two‐country Dynamic Stochastic General Equilibrium (DSGE) model, we derive a structural decomposition in which the nominal exchange rate is a function of the expected present value of future neutral real interest rate differentials plus a business cycle factor and a purchasing power parity (PPP) factor. Country‐specific “r*” shocks in general require optimal monetary policy to pass these through to the policy rate, but such shocks will also have exchange rate implications, with an expected decline in the path of the real neutral policy rate reflected in a depreciation of the nominal exchange rate. We document a novel empirical regularity between the equilibrium error in the Vector Error Correction Model (VECM) representation of the empirical Holston, Laubach, and Williams (HLW) four‐country r* model and the value of the nominal trade weighted dollar. In fact, the correlation between the dollar and the 12‐quarter lag of the HLW equilibrium error is estimated to be 0.7. Global shocks to r* under optimal policy require no exchange rate adjustment because passing though r* shocks to policy rates “does all the work” of maintaining global equilibrium. We also study a richer model with international spillovers so that in theory there can be gains to international policy cooperation. In this richer model, we obtain a similar decomposition for the nominal exchange rate, but with the added feature that r* in each country is a function of global productivity and business cycle factors even if these factors are themselves independent across countries. We argue that in practice, there could well be significant costs to central bank communication and credibility under a regime of formal policy cooperation, but that gains to policy coordination could be substantial given that r*s are correlated across countries.