bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adolescents’ involvement in mental health treatment and service design: a systematic review
Authors: Viksveen Petter , Cardenas Nicole Elizabeth , Berg Siv Hilde , Salamonsen Anita , Game Julia Rose , Bjønness Stig 
Published: November 2024

Abstract
Background
Adolescents’ involvement in their mental healthcare is considered a fundamental human right. However, there is a lack of consensus regarding the extent and nature of user involvement and limited research on user involvement in adolescent mental healthcare has previously been identified. Given the evolving focus on this area, this study explores the experiences with, the effectiveness of, and safety issues related to adolescents’ user involvement in mental healthcare.

Method
We conducted a systematic review, updating our original review with current research evidence relating to adolescents’ involvement in mental healthcare at individual and organizational levels. Searches across six databases, screening of reference lists, and suggestions from experts within the field helped to identify 5,527 records, of which 251 full text articles were screened. Established guidelines were used for data extraction, critical appraisal, and reporting of results.

Results
Collectively, the literature searches resulted in 36 eligible studies, of which 28 provided qualitative data and eight provided quantitative data. The quantitative studies identified the importance of personal help and online tools to support adolescents’ involvement in their mental healthcare. A few qualitative studies suggested shared decision-making is associated with improved self-reported mental health and treatment satisfaction. No studies focused on safety issues. A thematic synthesis of qualitative studies yielded four themes at the individual level and two themes at the organizational level. The findings highlight the growing recognition of adolescents' right to be involved and their capacity to take part in decision-making, emphasizing shared decision-making, two-way communication, and trust as key components of a collaborative relationship fundamental to user involvement. Further facilitators for user involvement at both individual and organizational levels are described.

Conclusion
The significance of user involvement in adolescent mental healthcare is underscored by a sense of increased empowerment and services tailored to meet adolescents’ needs. The evidence gathered from qualitative studies suggests involving adolescents in their treatment contributed to greater motivation for treatment, higher attendance rates, and treatment continuation. User involvement should emphasize adolescents’ preferences and a collaborative relationship that incorporates shared decision-making. Further implications for future practice and research are discussed.
Physical activity and mental health: a systematic review and best-evidence synthesis of mediation and moderation studies
Authors: White Rhiannon L. , Vella Stewart , Biddle Stuart , Sutcliffe Jordan , Guagliano Justin M. , Uddin Riaz , Burgin Alice , Apostolopoulos Maria , Nguyen Tatiana , Young Carmen , Taylor Nicole , Lilley Samantha , Teychenne Megan 
Published: November 2024

Abstract
Background
While evidence consistently demonstrates that physical activity is beneficial to mental health, it remains relatively unknown how physical activity benefits mental health, and which factors influence the effect of physical activity on mental health. This understanding could vastly increase our capacity to design, recommend, and prescribe physical activity in more optimal ways. The purpose of this study was to systematically review and synthesise evidence of all mediators and moderators of the relationship between physical activity and mental health.

Methods
Systematic searches of four databases (i.e., Scopus, PsycINFO, PubMed, and SPORTDiscus) identified 11,633 initial studies. Empirical studies that quantitatively assessed physical activity, or conducted a physical activity intervention, measured a mental health outcome, and tested one or more mediator or moderator of the relationship between physical activity and mental health were included. A total of 247 met the inclusion criteria; 173 studies examined mediation and 82 examined moderation.

Results
Results of the best-evidence synthesis revealed strong evidence for 12 mediators including affect, mental health and wellbeing, self-esteem, self-efficacy, physical self-worth, body image satisfaction, resilience, social support, social connection, physical health, pain, and fatigue. Moderate evidence was identified for a further 15 mediators and eight moderators.

Conclusions
Findings should inform the design of future physical activity interventions to ensure optimal effects on mental health related outcomes. Additionally, if health professionals were to take these mediators and moderators into consideration when prescribing or recommending physical activity, physical activity would likely have a greater impact on population mental health.
Right ventricular volume overload reboots cardiomyocyte proliferation via immune responses
Authors: Zhou Chunxia , Hu Yuqing , Dong Zhuoya , Wang Zheng , Zheng Sixie , Li Debao , Xiao Yingying , Chen Dian , Chen Hao , Sun Sijuan , Ye Lincai , Zhang Haibo 
Published: November 2024

Abstract
Background
Right ventricular volume overload (RVVO) is one of the most important hemodynamic characteristics in children with congenital heart disease (CHD) and heart failure, and cardiomyocyte (CM) proliferation is one of the most vital factors for improving cardiac performance. However, whether and how RVVO reboots CM proliferation remains elusive.

Methods and results
We first created a neonatal RVVO mouse model via abdominal aorta and inferior vena cava-fistula microsurgery at postnatal day 7 (P7), the edge of CM proliferation window. We subsequently performed bulk RNA-seq, single cell RNA-seq/flow cytometry, and immunofluorescence staining on the right ventricles (RV) of RVVO mice at P14/P21, defined as prepubertal stage, revealing that RVVO temporarily reboots prepubertal CM proliferation via immune responses.

Conclusions
In considering the importance of RVVO and CM proliferation, this study may bring an opportunity to create a novel paradigm to treat pediatric CHDs or heart failure.

Graphical Abstract
Population genomics of a thermophilic cyanobacterium revealed divergence at subspecies level and possible adaptation genes
Authors: Chang Hsin-Ying , Yen Hsi-Ching , Chu Hsiu-An , Kuo Chih-Horng 
Published: November 2024

Abstract
Background
Cyanobacteria are diverse phototrophic microbes with ecological importance and potential for biotechnology applications. One species of thermophilic cyanobacteria, Thermosynechococcus taiwanensis, has been studied for biomass pyrolysis, estrogen degradation, and the production of bioethanol, monosaccharide, and phycocyanin. To better understand the diversity and evolution of this species, we sampled across different regions in Taiwan for strain isolation and genomic analysis.

Results
A total of 27 novel strains were isolated from nine of the 12 hot springs sampled and subjected to whole genome sequencing. Including strains studied previously, our genomic analyses encompassed 32 strains from 11 hot springs. Genome sizes among these strains ranged from 2.64 to 2.70 Mb, with an average of 2.66 Mb. Annotation revealed between 2465 and 2576 protein-coding genes per genome, averaging 2537 genes. Core-genome phylogeny, gene flow estimates, and overall gene content divergence consistently supported the within-species divergence into two major populations. While isolation by distance partially explained the within-population divergence, the factors driving divergence between populations remain unclear. Nevertheless, this species likely has a closed pan-genome comprising approximately 3030 genes, with our sampling providing sufficient coverage of its genomic diversity. To investigate the divergence and potential adaptations, we identified genomic regions with significantly lower nucleotide diversity, indicating loci that may have undergone selective sweeps within each population. We identified 149 and 289 genes within these regions in populations A and B, respectively. Only 16 genes were common to both populations, suggesting that selective sweeps primarily targeted different genes in the two populations. Key genes related to functions such as photosynthesis, motility, and ion transport were highlighted.

Conclusions
This work provides a population genomics perspective on a hot spring cyanobacterial species in Taiwan. Beyond advancing our understanding of microbial genomics and evolution, the strains collected and genome sequences generated in this work provide valuable materials for future development and utilization of biological resources.
TbpB-based oral mucosal vaccine provides heterologous protection against Glässer’s disease caused by different serovars of Spanish field isolates of Glaesserella parasuis
Authors: González-Fernández Alba , Mencía-Ares Oscar , García-Iglesias María José , Petrocchi-Rilo Máximo , Miguélez-Pérez Rubén , Perelló-Jiménez Alberto , Herencia-Lagunar Elena , Acebes-Fernández Vanessa , Gutiérrez-Martín César B. , Martínez-Martínez Sonia 
Published: November 2024

Abstract
Background
Glaesserella parasuis (G. parasuis) is the primary agent of Glässer’s disease, significantly affecting nursery and early fattening piglets. Current prophylactic measures, mainly serovar-specific bacterins administered to sows, are limited by maternal immunity, which can interfere with active immunization in piglets. Subunit vaccines containing G. parasuis-specific antigenic molecules show promise but are not yet commercially available. Transferrin-binding proteins (Tbp), which enable G. parasuis to acquire iron in low-iron environments like mucosal surfaces, have been proposed as potential vaccine antigens. The mucosal administration of a TbpB-based subunit vaccine could provide a promising solution to overcome the limitations posed by maternal immunity, offering an effective approach to control the disease in weaning piglets. This study, conducted in two phases, primarily evaluates (days 0–45) the immunogenicity of a two-dose oral mucosal TbpB-based subunit vaccine (TbpBY167A) administered to colostrum-deprived piglets, and subsequently (days 45–52), its heterologous protection by challenging these piglets with four G. parasuis clinical isolates from different TbpB clusters (I, III) and serovars (SV1, SV4, SV5, SV7) recovered from Spanish pig farms.

Results
The oral mucosal administration of the two-dose TbpB-based vaccine induced a robust humoral immune response in immunized colostrum-deprived piglets, significantly increasing IgA and IgM concentration 15 days after the second dose (p < 0.01). Upon challenge with four G. parasuis clinical isolates, the vaccine demonstrated heterologous protection, markedly improving survival rates (OR: 8.45; CI 95%: 4.97–14.36) and significantly reducing clinical signs and lesions, regardless of the TbpB cluster and serovar. The vaccine reduced G. parasuis colonization in the respiratory tract (p < 0.0001) and G. parasuis systemic target tissues, like tarsus and carpus joints, liver, and brain (p < 0.05). Immunohistochemical analysis showed a lower macrophage count in different lung locations of immunized piglets (p < 0.0001).

Conclusions
This study demonstrates that oral mucosal administration of the TbpBY167A subunit vaccine in piglets provides effective heterologous protection against diverse virulent European G. parasuis field isolates, significantly reducing bacterial colonization and dissemination. This vaccine offers a promising alternative to traditional bacterins, overcoming limitations due to maternal immunity, and represents a strong candidate for universal vaccination against Glässer’s disease.
An unusual case of primary pulmonary synovial sarcoma
Authors: Dole Sachinkumar , Barthwal M. S. 
Published: November 2024

Abstract
Background
An extremely rare intrathoracic tumour that typically affects young adults is primary pulmonary synovial sarcoma. It manifests as a big intrathoracic mass without involvement of the bone or mediastinal region. Tumour biopsy, immunostaining and histologic analysis can assist in determining the kind of tumour.

Case presentation
We present a case of a 25-year-old male with complaints of breathlessness and chest pain for a month. On radiological imaging, he was found to have mass in upper and middle zones of right hemithorax. For confirmation of diagnosis, the patient underwent ultrasound-guided biopsy of the lesion and histopathologhical examination (HPE) of the lesion. The histopathological features were suggestive of a rare type of lung malignancy. For further diagnosis regarding type of malignancy, immunohistochemical staining of the lesion was done with the help of with specific immunological markers, which confirmed the diagnosis of monophasic pulmonary sarcoma. On PET (positron emission tomography) CT (computed tomography) scan, there were no features suggestive of distant metastasis especially in extremities which confirmed the diagnosis of primary pulmonary synovial sarcoma. Patient was started on chemotherapy regimen of ifosfamide and doxorubicin after oncologist’s opinion but was lost to follow up after 3rd cycle of chemotherapy.

Conclusions
Primary pulmonary synovial sarcoma is an extremely uncommon tumour in young adults as lung metastases from other sources mainly extremities are more common. Diagnosis of such rare tumour requires histopathological examination along with immunohistochemical staining of the lung lesions. A multimodal strategy of treatment involving resection, chemotherapy and radiation is used for the treatment of such tumours.
Empagliflozin-induced Myopathy
Authors: Khan Sana , Broce Ashley 
Published: November 2024

Abstract
Sodium/glucose co-transporter 2 (SGLT2) inhibitors are a frequently used medication for patients with type 2 diabetes, congestive heart failure (CHF), and chronic kidney disease. We present a 47-year-old patient with past medical history of type 2 diabetes and CHF who was initiated on empagliflozin and subsequently developed muscle pain and weakness. Evaluation of patient and laboratory testing confirmed drug-induced myopathy with elevated creatinine kinase (CK). Symptoms of myopathy and elevated CK resolved after holding empagliflozin. There are no current adverse effects listed with SGLT2 inhibitors including myopathy or rhabdomyolysis with the exception of other case studies. Physicians should be aware of this rare but serious side effect when initiating SGLT2 inhibitors.
Petrobras: um caso sobre as respostas estratégicas da empresa em 2020 decorrentes da COVID-19 e os seus efeitos nas demonstrações financeiras da empresa
Authors: Ribeiro Alessandro Maurício Januário , Borré Vitor Santos 
Published: November 2024

Informamos que as notas de ensino dos casos possuem acesso restrito e são exclusivas para docentes e instrutores vinculados à uma instituição acadêmica. Saiba mais.
Desenvolvimento e avaliação da usabilidade e aceitabilidade do aplicativo simplic – simplificando a insuficiência cardíaca
Authors: Brasil Barroso Filho Haroldo , Barbosa Ferreira da Silva Igor , Alexandre Lima Rocha Hermano , Da Silva de Oliveira Borges Tarsila Alice , Tomé de Sousa Rebeca , Borges Gleydson 
Published: November 2024

Introdução: A insuficiência cardíaca (IC) é uma doença com elevada prevalência, e morbi-mortalidade, levando a muitas internações devidos à sua descompensação. Devido à necessidade de melhorar o manejo da IC, foi criado um aplicativo acessível e de uso prático para médicos, contendo informações e dados científicos sobre o tema, segundo as diretrizes brasileiras vigentes. Objetivos: Desenvolver e avaliar a usabilidade e aceitabilidade de um aplicativo para manejo terapêutico da IC, SIMPLIC – Simplificando a Insuficiência Cardíaca. Métodos: Desenvolveu-se um aplicativo nas plataformas iOs® e Android®, contendo manejo diagnóstico e terapêutico da IC. Para avaliar a usabilidade e a aceitabilidade, este foi utilizado por cinco grupos de profissionais da saúde, totalizando sessenta profissionais. Foram utilizados os instrumentos System Usability Score (SUS) e do Technology Acceptance Model (TAM). Foi realizada análise estatística descritiva e de teste de hipóteses com o software SPSS v23, IBM. Resultados: Foi desenvolvido o aplicativo SIMPLIC, baseado na Diretriz Brasileira de IC Aguda e Crônica, de 2018, atualizada em 2021, com informações sobre definição, manejo diagnóstico e terapêutico. A avaliação da usabilidade e aceitabilidade do aplicativo demonstraram resultados muito satisfatórios (SUS = x̄ = 75,2, (IC 95% 74,2 – 76,2), TAM x̄ = 90,6, (IC 95% 88,9 – 92,2)), sem diferenças estatísticas em relação aos cinco grupos de profissionais que testaram o programa. Conclusões: O SIMPLIC oferece acesso a informações sobre o manejo diagnóstico e terapêutico da IC e mostrou excelente usabilidade e aceitabilidade, o que sugere o potencial benefício do seu uso nos diversos serviços de saúde.
Das Framework for Information Literacy for Higher Education der ACRL: Sein Potenzial für die Vermittlung von Informationskompetenz und seine Auswirkungen auf die Vermittlungspraxis der Teaching Librarians im deutschen Sprachraum
Authors: Zemanek Michaela 
Published: November 2024

Zusammenfassung
Das Framework for Information Literacy for Higher Education der ACRL brachte einen Paradigmenwechsel für die Vermittlung von Informationskompetenz an Hochschulen. Der Artikel diskutiert das Potenzial und die Reichweite des Frameworks und geht der Frage nach, welche Auswirkungen das Framework auf die Schulungs- bzw. Unterrichtspraxis der Teaching Librarians
Als „Teaching Librarians“ werden Bibliothekar*innen bezeichnet, die in Bibliotheken schulen bzw. unterrichten (Sühl-Strohmenger (2015) 2.
hat. Rezeption und Umsetzung des Frameworks werden in einer Literaturübersicht dargestellt und in einer Umfrage der Autorin untersucht. Die Ergebnisse der Befragung sollen zeigen, wie das Framework im deutschen Sprachraum angekommen ist. Wird es als brauchbar für die Praxis angesehen? In welchem Ausmaß wird es umgesetzt? Welche Inhalte bzw. Schwellenkonzepte werden in die Unterrichtspraxis einbezogen? Haben sich die fachlichen Kompetenzen der Teaching Librarians dadurch verändert? In welcher Weise hat sich der Unterricht dadurch verändert?
Contested Heterotopias: Translation Technologies in Post-Devolution Welsh-Language Drama
Authors: Evans Gareth Llŷr 
Published: November 2024

Abstract
This article examines the use of English-language surtitles within Welsh-language performances, aiming to consider their potential impact for a minority-language theatre culture. Having been utilised with increasing frequency over the past decade, their prominence signals an overdue and welcome attempt to expand audiences and to increase access for Welsh-speaking and non-Welsh-speaking audiences alike. Their use is a fairly recent development within the relatively brief history of Welsh-language theatre. Therefore, the study examines their presence in relation to the preceding century and a half and considers how the visual inclusion of English-language text within a Welsh-language mise en scène signals a subtle but potentially substantial interruption to what has historically been the function of the Welsh-language theatrical event. Prior to the use of translation technologies, Welsh-language drama could be performed for a presumed Welsh-language audience with the tacit assumption its linguistic text could be comprehended by all in attendance. This might no longer be the case. But by considering the presence of surtitles as dramaturgical material, the study will consider what the implications of their inclusion might be for a constituent audience that has no need for an English-language translation.
A Journey towards Womanist Agency in debbie tucker green’s trade
Authors: Ashrafkhani Limoudehi Babak 
Published: November 2024

Abstract
In her plays, debbie tucker green depicts how Black women transcend sheer subjection and achieve autonomy to deal with colonial oppression, socioeconomic inequalities, and male hegemony. In her 2005 play trade, she addresses interlocking sexism, classism, and racism that have subjugated Black women. tucker green creates a single-sex atmosphere in which white female sexuality is not celebrated at the expense of Black female/male identity and subverts hegemonic masculinity and racial objectification through shattered stereotyping. This article scrutinizes tucker green’s trade by means of the concepts of womanism and agency as strategies to oppose the hegemonic racial, sexual, and social norms, and to examine the development of female (subject) identity. Concerned with both racial and sexual survival, womanism is a strategy employed by Black women to achieve agency through the empowering dynamics of “audacity” and “communitarianism.” Judith Butler’s concept of agency is depicted through the stereotyped characters – Regular, Novice, and Local – and their subversion. tucker green’s proclivity for a structural experimentalism resists stereotyped and coded hegemonic behaviour. She employs cross-race and double casting techniques to challenge sexual identities determined by dominant sexual ideologies. The process of transition to agency and the gradual movement from subjection to resistance is observable not only in the metatheatrical structure of the play but also in the performative language of the characters as constructive steps towards subjectivity.
Lever arm measurement precision and its impact on exterior orientation parameters in GNSS/IMU integration
Authors: Jouybari Arash , Bagherbandi Mohammad , Nilfouroushan Faramarz 
Published: November 2024

Abstract
Airborne mobile mapping systems are crucial in various geodetic applications. A key aspect of these systems is the accurate estimation of exterior orientation parameters (EOPs), which is achieved through the integration of global navigation satellite systems (GNSSs) and inertial measurement unit (IMU) technologies. One critical component in this integration is the lever arm (LA), the vector that connects the GNSS antenna and the IMU center. The uncertainty (standard deviation) in LA measurements can introduce errors in the EOP estimation, thereby affecting the overall system performance. However, how much the EOP estimation is affected by LA measurement uncertainty is examined in this study based on calibration data (test flight) using the TerrainMapper 2 system collected by Lantmäteriet in Sweden. The findings reveal that LA uncertainties have minimal influence on attitude and negligible impacts on position in terms of standard deviation (SD) if the LA is measured with an accuracy of better than 2–3 cm. Additionally, the research explores the combined effects of virtual reference station-rover baseline length and dilution of precision on positioning accuracy and their correlation with LA uncertainty, providing further insights into the complexities of EOP estimation. By advancing GNSS/IMU integration techniques, this study contributes to the enhancement of geodetic technologies customized for airborne mobile mapping applications.