bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online engagement and cognitive function among older adults
Authors: Amini Reza , Chee Kyong Hee , Mendieta Maximiliano , Parker Shan 
Published: August 2019

AimSocial engagement is known to serve an important role in cognitive health, but there has been limited information on the role of online engagement. The present study aimed to identify the benefits of different online activities for the cognitive function of older adults.MethodsData came from the National Health and Aging Trend Study, Round I–V (2011–2015), with >8000 respondents from Medicare beneficiaries. Cognitive function was measured by the Clock Drawing Test and immediate 10‐word recall. The respondents were also asked if they carried out any of the online activities listed.ResultsSome online activities, such as email, texting and seeking medical information, can reduce the risk of cognitive decline. Whereas contacting a medical provider using online can increase the risk of cognitive decline.ConclusionsGiven the findings, the development of new technologies for online social engagement needs to be one of the priorities for researchers and policymakers in the field of aging and dementia. Geriatr Gerontol Int 2019; 19: 918–923.
Renewable sources: applications in personal care formulations
Authors: Mellou F. , Varvaresou A. , Papageorgiou S. 
Published: August 2019

AbstractA global tendency for products considered environmentally sustainable, and ecologically obtained led the industry related to personal care formulations to fund the research and the development of personal care/cosmetics containing ingredients from natural resources. Furthermore, consumers are aware of environmental and sustainability issueans, thus not harming the environment represents a key consideration when developing a new cosmetic ingredient. In this study we review some examples of active ingredients or raw materials used in cosmetics/personal care/biomedical products that are coming from either through biotechnological systems, or as byproducts of several industries. A skin formulation containing biosynthetic actives, prepared by us and the study regarding its dermocosmetic properties are also described. The need for the standardization processes, the safety assessment tools, the improvement of the exploitation methods of these renewable sources in order the production to be ecologically and economically better are also discussed.
Telmisartan cardioprotects from the ischaemic/hypoxic damage through a miR‐1‐dependent pathway
Authors: Trotta Maria Consiglia , Ferraro Bartolo , Messina Antonietta , Panarese Iacopo , Gulotta Eliana , Nicoletti Giovanni Francesco , D’Amico Michele , Pieretti Gorizio 
Published: August 2019

AbstractThe aim of this study was to investigate whether telmisartan protects the heart from the ischaemia/reperfusion damage through a local microRNA‐1 modulation. Studies on the myocardial ischaemia/reperfusion injury in vivo and on the cardiomyocyte hypoxia/reoxygenation damage in vitro were done. In vivo, male Sprague‐Dawley rats administered for 3 weeks with telmisartan 12 mg/kg/d by gastric gavage underwent ischaemia/reperfusion of the left descending coronary artery. In these rats, infarct size measurement, ELISA, immunohistochemistry (IHC) and reverse transcriptase real‐time polymerase chain reaction showed that expressions of connexin 43, potassium voltage‐gated channel subfamily Q member 1 and the protein Bcl‐2 were significantly increased by telmisartan in the reperfused myocardium, paralleled by microRNA‐1 down‐regulation. In vitro, the transfection of cardiomyocytes with microRNA‐1 reduced the expressions of connexin 43, potassium voltage‐gated channel subfamily Q member 1 and Bcl‐2 in the cells. Telmisartan (50 µmol/L) 60 minutes before hypoxia/reoxygenation, while not affecting the levels of miR‐1 in transfected cells in normoxic condition, almost abolished the increment of miR‐1 induced by the hypoxia/reoxygenation to transfected cells. All together, telmisartan cardioprotected against the myocardial damage through the microRNA‐1 modulation, and consequent modifications of its downstream target connexin 43, potassium voltage‐gated channel subfamily Q member 1 and Bcl‐2.
Recurrence rate and associated factors of borderline ovarian tumors in the south of Vietnam
Authors: Vo Tuan M. , Duong Kim A. , Tran Ly T.‐H. , Bui Thanh C. 
Published: August 2019

AbstractAimThis study aimed to determine the recurrence rate and related risk factors of borderline ovarian tumors (BOT).MethodsWe conducted a retrospective cohort study with 433 patients who were surgically treated for primary BOT at Tu Du Hospital from 11/2008 to 09/2015. We used the life table method to estimate the cumulative recurrence rate. We used the log–rank test and Cox proportional hazard model to determine recurrence‐associated factors.ResultsMedian follow‐up time was 43 months (range: 3–105 months). Eighteen patients developed recurrence. The cumulative BOT recurrence rates at year 1, 2, 3 and 4 were 1.2% (95% confidence interval [CI] = 0.5–2.8), 3.0% (95% CI = 1.7–5.2), 4.6% (95% CI = 2.9–7.4), and 5.1% (95% CI = 3.2–8.0), respectively. In the final multivariate model, a higher recurrence rate was significantly associated with primary tumor stages (stage I vs stages II and III, hazards ratio [HR] = 4.44, 95% CI = 1.60–12.38), pre‐operative tumor's capsule rupture (HR = 4.14, 95% CI = 1.78–9.64), and cystectomy (HR = 5.33, 95% CI = 1.43–19.91).ConclusionThe overall BOT recurrence rate in women in southern Vietnam was moderate. Primary tumor stage, capsule rupture, and cystectomy were main factors associated with BOT recurrence. Appropriate follow‐up strategies for patients with high‐risk factors are needed for early detection and management of recurrence.
Case report of two pregnancies and deliveries by a woman with Buerger disease
Authors: Ohwada Tetsuro , Kamiyama Yoichiro , Watanabe Koji , Kamiyama Tomonari , Maeda Tsuyoshi , Mori Yu 
Published: August 2019

AbstractBuerger disease is a chronic inflammatory disease that involves blood clot formation in the medium and small arteries, resulting in thrombophlebitis. It is usually observed in middle‐aged men who smoke and is very rare in young women. Previous reports have indicated that Buerger disease worsens during pregnancy due to hypercoagulability associated with pregnancy, and newborns' birth weights were often lower than normal. This report describes a young woman with Buerger disease who experienced two pregnancies and deliveries. During the 1st pregnancy, d‐dimer and soluble fibrin levels slightly increased, but no treatment was needed. However, during the 2nd pregnancy, d‐dimer and soluble fibrin levels abruptly increased at 20 weeks of pregnancy, and heparin was administered subcutaneously. Four days after heparin administration, d‐dimer and soluble fibrin levels decreased to normal pregnancy levels. d‐dimer and soluble fibrin measurements were useful for evaluating the coagulation tendencies of this pregnant woman with Buerger disease.
Temporal profiling of simplified lemonade using temporal dominance of sensations and temporal check‐all‐that‐apply
Authors: Wu Anna Zhenan , Lee Rachel W. , Calvé Bénédicte Le , Cayeux Isabelle 
Published: August 2019

AbstractGiven that little is known about how sensory interactions during lemonade consumption unfold over time, we studied the impact of citric acid level and type of sweetener on dynamic perception of simplified lemonade using temporal dominance of sensations (TDS) and temporal check‐all‐that‐apply (TCATA). We found that citric acid level did not impact perception of lemon flavor. Instead, the sweetener type had an impact on the rate and duration with which lemon flavor was perceived as dominant in TDS, but not its overall citation duration and rates in TCATA. In terms of licorice taste, SG 95 (95% steviol glycosides) solutions with higher levels of citric acid had relatively lower dominance/citation rates and duration than SG 95 samples with lower levels of citric acid. Sweetness was perceived to be more dominant and more frequently cited for sucrose than SG 95 solutions, especially at the early tasting stage. Finally, results showed that both TDS and TCATA provided useful and complementary information for the study of sensory interactions.Practical ApplicationsUnderstanding the dynamic sensory interaction of cross‐modality perceptions of lemonade could help product developers to formulate the low calorie natural sweetener drink. The results elucidate the impact of sweetener type and citric acid level on dynamic perception of simplified lemonade. TDS and TCATA are able to provide complementary information on dynamic sensory perception.
Effects of supplementing broiler diets with coriander seed powder on growth performance, blood haematology, ileum microflora and economic efficiency
Authors: Taha Ayman E. , Hassan Saber S. , Shewita Ramadan S. , El‐seidy Ahmed A. , Abd El‐Hack Mohamed E. , Hussein El-sayed O.S. , Saadeldin Islam M. , Swelum Ayman A. , El‐Edel Mohamed A. 
Published: August 2019

AbstractA total of 480 one‐day‐old Arbor Acres broiler chicks were randomly assigned to four dietary groups, each including six replicates (n = 20/replicate). Broilers in the first group (G1) were fed a basal diet without any additives (control). Broilers in groups 2, 3 and 4 (G2, G3 and G4) were fed a basal diet supplemented with 0.1%, 0.2% and 0.4% coriander (Coriandrum sativum L.) seed powder (CSP) respectively. Feeding trials lasted for 42 days, and after that growth, carcass traits, haematological parameters, gut microbiota and economic efficiency (EE) were evaluated. Final body weight (FBW), total weight gain (TWG), total feed intake (TFI) and red blood cell (RBC) counts of broilers in the G4 and G3 treatment groups were significantly higher (p < .05) compared with broilers in the G1 treatment group. The feed conversion ratio (FCR) was better (p < .05) in the G4 treatment group (1.72) than in the G1 treatment group (1.84). Broilers in CSP treatment groups had significantly higher haemoglobin (Hb) concentrations, packed cell volume (PCV) and platelet counts, and had lower (p < .05) Escherichia coli and Clostridium perfringens counts compared with broilers in the G1 treatment group. Dressing, liver, pancreas, bursa and thymus percentages were higher (p < .05) in broilers in the G4 (70.30, 3.18, 0.31, 0.10 and 0.32% respectively) treatment group, compared with broilers in the control (G1) group (66.57, 2.37, 0.23, 0.04 and 0.21% respectively). Broilers in treatment groups G4 and G3 had lower percentages of abdominal fat and lower total bacterial counts (p < .05) than broilers in treatment groups G2 and G1. The highest economic efficiency (EE) was found in treatment group G4, and EE in this group was 13.06% greater than in the control (G1) group.
An ensemble machine learning‐based modeling framework for analysis of traffic crash frequency
Authors: Zhang Xiang , Waller S. Travis , Jiang Peng 
Published: August 2019

AbstractThis study is, to our knowledge, the first in the literature to introduce a modeling framework for analyzing traffic crash frequency based on a series of ensemble machine learning (EML) methods. The main objectives of this study are fourfold: (a) to design a systematic EML‐based framework for crash frequency analysis, (b) to comprehensively compare the performance in analyzing crash frequency by different optimized EML models, (c) to identify significant contributors to crash frequency, and (d) to propose the approach to construct schemes to reduce traffic crashes. To achieve the research goal, the Highway Safety Information System database that includes records of over 1.5 million crashes is employed for model estimation and validation. We first optimize the EML models for crash analysis via the k‐fold cross‐training, including the two averaging methods of random forest and extremely randomized trees, and the two boosting methods of adaptive boosting and gradient tree boosting. Then, we assess the behavior of the optimized models, and conduct a sensitivity test to validate the stability of model performance. Furthermore, we evaluate the relative importance of features to crash frequency by using the Gini diversity index. The results indicate that the two averaging EML models can achieve desirable performance in crash frequency analysis, which outperform the two boosting EML models, in terms of predictive accuracy, generalization ability, and stability. From the results, we explore new insights into the significance of contributors to crash occurrence. Finally, we present the approach of safety improvements for transport facilities.
Diagnosis and treatment of otomycosis in southern China
Authors: Li Yongqi , He Lifeng 
Published: August 2019

SummaryTo analyse and discuss the clinical features and pathogenic characteristics, diagnosis and treatment of patients with otomycosis in southern China. Two hundred fifty‐six patients from southern China diagnosed with otomycosis were randomly separated into two groups: the drug filling group and drug smearing group. Patients in the drug filling group were first examined and then had the pathogenic secretions in their external auditory canals cleared by otoendoscopy. Then, the local antifungal cream triamcinolone acetonide clotrimazole was injected into the external auditory canal. The same treatment was undertaken 1 week later and repeated once or twice more. Patients in the drug smearing group were also treated by otoendoscopy. Then, they were told to smear their external auditory canals once per day with the antifungal cream. All cases were followed for more than 6 months after the 3‐ to 4‐week treatment. The main symptoms and otoendoscopic examination were used to evaluate the prognosis. Aspergillus was the commonest fungus. The cure rate was 93% in the drug filling group and 81% in the drug smearing group. Otomycosis is very common in southern China, but it lacks characteristic features in its early stages. Once diagnosed, the local lesions in the external auditory canal should be cleared thoroughly using otoendoscopy, and then, the local antifungal cream is injected into external auditory canal. The cure rate can be significantly improved with the foregoing treatment.
Imaging and spatial analysis of hematopoietic stem cell niches
Authors: Gomariz Alvaro , Isringhausen Stephan , Helbling Patrick M. , Nombela‐Arrieta César 
Published: August 2019

AbstractHematopoietic stem cells (HSCs) have been long proposed to reside in defined anatomical locations within bone marrow (BM) tissues in direct contact or close proximity to nurturing cell types. Imaging techniques that allow the simultaneous mapping of HSCs and interacting cell types have been central to the discovery of basic principles of these so‐called HSC niches. Despite major progress in the field, a quantitative and comprehensive model of the cellular and molecular components that define these specialized microenvironments is lacking to date, and uncertainties remain on the preferential localization of HSCs in the context of complex BM tissue landscapes. Recent technological breakthroughs currently allow for the quantitative spatial analysis of BM cellular components with extraordinary precision. Here, we critically discuss essential technical aspects related to imaging approaches, image processing tools, and spatial statistics, which constitute the three basic elements of rigorous quantitative spatial analyses of HSC niches in the BM microenvironment.
Focusing on the nuclear and subnuclear dynamics of light and circadian signalling
Authors: Ronald James , Davis Seth J. 
Published: August 2019

AbstractCircadian clocks provide organisms the ability to synchronize their internal physiological responses with the external environment. This process, termed entrainment, occurs through the perception of internal and external stimuli. As with other organisms, in plants, the perception of light is a critical for the entrainment and sustainment of circadian rhythms. Red, blue, far‐red, and UV‐B light are perceived by the oscillator through the activity of photoreceptors. Four classes of photoreceptors signal to the oscillator: phytochromes, cryptochromes, UVR8, and LOV‐KELCH domain proteins. In most cases, these photoreceptors localize to the nucleus in response to light and can associate to subnuclear structures to initiate downstream signalling. In this review, we will highlight the recent advances made in understanding the mechanisms facilitating the nuclear and subnuclear localization of photoreceptors and the role these subnuclear bodies have in photoreceptor signalling, including to the oscillator. We will also highlight recent progress that has been made in understanding the regulation of the nuclear and subnuclear localization of components of the plant circadian clock.
PART I: The role of public health nursing in addressing health care needs of children in foster care
Authors: Carabez Rebecca , Kim Jung Eun 
Published: August 2019

AbstractAims and ObjectivesThe purpose of this study was to describe the role of Public Health Nurses (PHN) addressing the needs of children and adolescents in foster care.BackgroundChildren in foster care have more physical, mental, dental, developmental health problems than the general pediatric population. National data indicate that between 30%‐80% of children come into foster care with at least one physical health problem.DesignAn online survey was developed to describe PHN day‐to day activities, PHN funding, case load and case management responsibilities.MethodThirty‐nine PHNs completed the survey (72% response rate).ResultsNurses described the most important needs as being mental and emotional health services, self‐esteem/self‐worth and dental care. Care coordination, case management and monitoring/oversight of psychotropic medications were the top responsibilities.ConclusionThe study demonstrated that public health nursing expertise is an essential part of the child welfare team in addressing medical, dental, mental and developmental needs of children in foster care.Relevance to Clinical PracticeThere is an expanding role of Public Health Nurses in non‐health care settings to intervene at the system level of the Intervention Wheel that includes policy development and enforcement, community organizing, and coalition building.
Calcicole behaviour of Callisthene fasciculata Mart., an Al‐accumulating species from the Brazilian Cerrado
Authors: de Souza M. C. , Williams T. C. R. , Poschenrieder C. , Jansen S. , Pinheiro M. H. O. , Soares I. P. , Franco A. C. 
Published: August 2019

Abstract

Most aluminium (Al)‐accumulating species are found on soils with high Al saturation and low Ca availability (Ca poor). Callisthene fasciculata Mart. (Vochysiaceae), however, is an Al‐accumulating tree restricted to Ca‐rich soils with low Al saturation in the Brazilian Cerrado savanna. Here we tested its calcicole behaviour, and the possible role of organic acids in detoxification of Al during the early stages of plant development.

We assessed growth, dry mass, nutrients, Al and organic acids in seedlings grown for 50 days on two contrasting Cerrado soils; one with high Ca concentrations and low Al saturation and the other with low Ca availability and high Al saturation.

Relative to plants on Ca‐rich soil, plants on Ca‐poor soil had necrotic spots and bronzing of leaves. Roots and shoots contained reduced concentrations of P and Cu, but higher concentrations of Fe, Al and citrate. Despite lower concentrations in the soil, Ca and Mg increased in shoots. Shoot concentrations of oxalate were also higher.

We confirmed C. fasciculata as an Al‐accumulating species with calcicole behaviour. The increased concentrations of organic acids in plants with higher Al accumulation suggest that high availability of soluble Al does not prevent occurrence of this species on soils with high Al saturation. Instead, the absence of C. fasciculata from Ca‐poor soils is probably due to imbalances in tissue Fe, Cu and Zn imposed by this soil type.
Unitization modulates recognition of within‐domain and cross‐domain associations: Evidence from event‐related potentials
Authors: Li Bingcan , Han Meng , Guo Chunyan , Tibon Roni 
Published: August 2019

AbstractAlthough it is often assumed that memory of episodic associations requires recollection, it has been suggested that, when stimuli are experienced as a unit, earlier memory processes might contribute to their subsequent associative recognition. We investigated the effects of associative relations and perceptual domain during episodic encoding on the ability to utilize early memory processes to retrieve associative information. During the study phase, participants encoded compound and noncompound words pairs, presented either to the same sensory modality (visual presentation) or to different sensory modalities (audiovisual presentation). At the test phase, they discriminated between old, rearranged, and new pairs while ERPs were recorded. In an early ERP component, differences related to associative memory emerged only for compounds, regardless of their encoding modality. These findings indicate that episodic retrieval of compound words can be supported by early‐onset recognition processes regardless of whether both words were presented to the same or different sensory modalities, and suggests that unitization can operate at an abstract level, across a broad range of materials.
Contrasting effects of heat shock during in vitro maturation on development of in vitro‐fertilized and parthenogenetic bovine embryos
Authors: Camargo Luiz Sergio Almeida , Costa Fernanda Queiros , Munk Michele , Wohlres‐Viana Sabine , Serapião Raquel Varela , Carvalho Bruno Campos , Campos Paulo Henrique , Vieira Alex Cabral , Nogueira Luiz Altamiro Garcia , Viana Joao Henrique Moreira 
Published: August 2019

AbstractThis study investigated the influence of heat shock during in vitro maturation on embryo development following in vitro fertilization (IVF) or parthenogenesis (Part). Immature bovine cumulus–oocyte complexes were exposed to heat shock (41.0°C) during the first 12 hr of in vitro maturation (IVM), followed by 12 hr at 38.5°C. Control group consisted of in vitro maturation for 24 hr at 38.5°C. Oocytes were in vitro‐fertilized or activated with ionomycin and cultured in vitro for 192 hr post‐in vitro insemination or parthenogenetic activation (hpia). There was an interaction (p < .01) between temperature of IVM and method of oocyte activation (IVF or Part) for cleavage at 48 hpia. Heat shock had a negative impact (p < .01) on cleavage of IVF embryos, whereas no (p > .05) effect was found in the Part embryos. Embryo development towards blastocyst stage at 168 and 192 hpia decreased in both IVF and Part embryos derived from heat‐shocked oocytes. Heat shock increased (p < .05) the apoptotic index in Part blastocysts, but no effect (p > .05) was found in IVF counterparts. Heat shock also down‐regulated the expression of AQP3 (p < .01) and up‐regulated the expression of HSP70.1 (p < .01) in Part blastocysts, whereas it down‐regulated the expression of ATP1A1 (p < .05) in IVF blastocysts. In conclusion, the effects of heat shock during IVM on early embryo cleavage and blastocyst apoptosis are influenced by the method of oocyte activation and expression of some genes can be disturbed in embryos derived from heat‐shocked oocytes.