bluuebunny/crossref_metadata_2025_split huggingface dataset:
Months‐Long Subduction Slow Slip Events Avoid the Stress Shadows of Seismic Asperities
Authors: Rousset Baptiste 
Published: June 2019

AbstractWith precise geodetic measurements, slow transient fault slip events with durations from days to years have been documented at subduction zones for two decades. Long‐lasting transient events with durations longer than 100 days occur at the downdip edge of seismogenic zones. With such long durations, only a few events have been documented so far. Takagi et al. (2019, https://doi.org/10.1029/2018JB016738) propose a new methodology to detect these events and successfully apply it to the Nankai subduction zone in which they characterize 24 events, including 11 new detections. Combined with other observations from around the Pacific rim, they suggest that the lateral segmentation of long‐lasting slow slip events is controlled by the location of seismic asperities associated with their stress shadows.
Public Attitudes to Inequality in Water Distribution: Insights From Preferences for Water Reallocation From Irrigators to Aboriginal Australians
Authors: Jackson Sue , Hatton MacDonald Darla , Bark Rosalind H. 
Published: June 2019

AbstractWater allocation regimes that adjudicate between competing uses are in many countries under pressure to adapt to increasing demands, climate‐driven shortages, expectations for equity of access, and societal changes in values and priorities. International authorities expound standards for national allocation regimes that include robust processes for addressing the needs of “new entrants” and for varying existing entitlements within sustainable limits. The claims of Indigenous peoples to water represents a newly recognized set of rights and interests that will test the ability of allocation regimes to address the global water governance goal of equity. No study has sought to identify public attitudes or willingness to pay for a fairer allocation of water rights between Indigenous and non‐Indigenous people. We surveyed households from the jurisdictions of Australia's Murray‐Darling Basin, a region undergoing a historic government‐led recovery of water, and found that 69.2% of respondents support the principle of reallocating a small amount of water from irrigators to Aboriginal people via the water market. Using contingent valuation, we estimated households are willing to pay A$21.78 in a one‐off levy. The aggregate value calculated for households in the basin's jurisdictions was A$74.5 million, which is almost double a recent government commitment to fund the acquisition of entitlements for Aboriginal nations of this basin. Results varied by state of residency and affinity with environmental groups. An information treatment that presented narrative accounts from Aboriginal people influenced the results. Insights from this study can inform water reallocation processes.
Characterization of gelatin/chitosan ploymer films integrated with docosahexaenoic acids fabricated by different methods
Authors: Cai Luyun , Shi Hang , Cao Ailing , Jia Jingze 
Published: June 2019

AbstractIn this study, docosahexaenoic acid powder-enhanced gelatin-chitosan edible films were prepared by casting, electrospinning and coaxial electrospinning, respectively. The color (CR), transparency (UV), light transmission (UV), mechanical strength (TA-XT), thermal stability (DSC), crystalline structures (XRD), molecular interactions (FTIR), and microstructure (SEM) were assessed in the analytical research. The results of the research showed that the electrospinning process and the coaxial electrospinning process produced a smooth surface visible to by the naked eye and a uniform granular network structure in a unique film-forming manner, thereby exhibiting good water solubility and mechanical properties. In contrast, the casted film was smooth, transparent, and mechanically strong but poorly water soluble. It was also found that the addition of docosahexaenoic acid powder affected the optical, physical and mechanical properties of the film to varying degrees.
The value of indocyanine green clearance assessment to predict postoperative liver dysfunction in patients undergoing liver resection
Authors: Schwarz Christoph , Plass Immanuel , Fitschek Fabian , Punzengruber Antonia , Mittlböck Martina , Kampf Stephanie , Asenbaum Ulrika , Starlinger Patrick , Stremitzer Stefan , Bodingbauer Martin , Kaczirek Klaus 
Published: June 2019

AbstractPostoperative liver dysfunction remains a major concern following hepatic resection. In order to identify patients who are at risk of developing liver dysfunction, indocyanine green (ICG) clearance has been proposed to predict postoperative liver function. All patients who underwent liver resection at the Medical University Vienna, Austria between 2006 and 2015 with preoperative ICG clearance testing (PDR, R15) were analyzed in this study. Postoperative liver dysfunction was analyzed as defined by the International Study Group of Liver Surgery. Overall, 698 patients (male: 394 (56.4%); female: 304 (43.6%)) with a mean age of 61.3 years (SD: 12.9) were included in this study, including 313 minor liver resections (44.8%) and 385 major liver resections (55.2%). One hundred and seven patients developed postoperative liver dysfunction after liver resection (15.3%). Factors associated with liver dysfunction were: male sex (p = 0.043), major liver resection (p < 0.0001), and preoperative ICG clearance (PDR (p = 0.002) and R15 (p < 0.0001)). Notably ICG clearance was significantly associated with liver dysfunction in minor and major liver resections respectively and remained a predictor upon multivariable analysis. An optimal cut-off for preoperative ICG clearance to accurately predict liver dysfunction was PDR < 19.5%/min and R15 > 5.6%. To the best of our knowledge, this is the largest study analyzing the predictive value of preoperative ICG clearance assessment in patients undergoing liver resection. ICG clearance is useful to identify patients at risk of postoperative liver dysfunction.
Visual Field Prediction using Recurrent Neural Network
Authors: Park Keunheung , Kim Jinmi , Lee Jiwoong 
Published: June 2019

AbstractArtificial intelligence capabilities have, recently, greatly improved. In the past few years, one of the deep learning algorithms, the recurrent neural network (RNN), has shown an outstanding ability in sequence labeling and prediction tasks for sequential data. We built a reliable visual field prediction algorithm using RNN and evaluated its performance in comparison with the conventional pointwise ordinary linear regression (OLR) method. A total of 1,408 eyes were used as a training dataset and another dataset, comprising 281 eyes, was used as a test dataset. Five consecutive visual field tests were provided to the constructed RNN as input and a 6th visual field test was compared with the output of the RNN. The performance of the RNN was compared with that of OLR by predicting the 6th visual field in the test dataset. The overall prediction performance of RNN was significantly better than OLR. The pointwise prediction error of the RNN was significantly smaller than that of the OLR in most areas known to be vulnerable to glaucomatous damage. The RNN was also more robust and reliable regarding worsening in the visual field examination. In clinical practice, the RNN model can therefore assist in decision-making for further treatment of glaucoma.
Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer
Authors: Zhu Guoyun , Foletti Davide , Liu Xiaohui , Ding Sheng , Melton Witt Jody , Hasa-Moreno Adela , Rickert Mathias , Holz Charles , Aschenbrenner Laura , Yang Amy H. , Kraynov Eugenia , Evering Winston , Obert Leslie , Lee Chenyu , Sai Tao , Mistry Tina , Lindquist Kevin C. , Van Blarcom Thomas , Strop Pavel , Chaparro-Riggers Javier , Liu Shu-Hui 
Published: June 2019

AbstractHuman CLDN18.2 is highly expressed in a significant proportion of gastric and pancreatic adenocarcinomas, while normal tissue expression is limited to the epithelium of the stomach. The restricted expression makes it a potential drug target for the treatment of gastric and pancreatic adenocarcinoma, as evidenced by efforts to target CLDN18.2 via naked antibody and CAR-T modalities. Herein we describe CLDN18.2-targeting via a CD3-bispecific and an antibody drug conjugate and the characterization of these potential therapeutic molecules in efficacy and preliminary toxicity studies. Anti-hCLDN18.2 ADC, CD3-bispecific and diabody, targeting a protein sequence conserved in rat, mouse and monkey, exhibitedin vitrocytotoxicity in BxPC3/hCLDN18.2 (IC50 = 1.52, 2.03, and 0.86 nM) and KATO-III/hCLDN18.2 (IC50 = 1.60, 0.71, and 0.07 nM) respectively and inhibited tumor growth of pancreatic and gastric patient-derived xenograft tumors. In a rat exploratory toxicity study, the ADC was tolerated up to 10 mg/kg. In a preliminary assessment of tolerability, the anti-CLDN18.2 diabody (0.34 mg/kg) did not produce obvious signs of toxicity in the stomach of NSG mice 4 weeks after dosing. Taken together, our data indicate that targeting CLDN18.2 with an ADC or bispecific modality could be a valid therapeutic approach for the treatment of gastric and pancreatic cancer.
High-dimensional detection of imaging response to treatment in multiple sclerosis
Authors: Kanber Baris , Nachev Parashkev , Barkhof Frederik , Calvi Alberto , Cardoso Jorge , Cortese Rosa , Prados Ferran , Sudre Carole H. , Tur Carmen , Ourselin Sebastien , Ciccarelli Olga 
Published: June 2019

AbstractChanges on brain imaging may precede clinical manifestations or disclose disease progression opaque to conventional clinical measures. Where, as in multiple sclerosis, the pathological process has a complex anatomical distribution, such changes are not easily detected by low-dimensional models in common use. This hinders our ability to detect treatment effects, both in the management of individual patients and in interventional trials. Here we compared the ability of conventional models to detect an imaging response to treatment against high-dimensional models incorporating a wide multiplicity of imaging factors. We used fully-automated image analysis to extract 144 regional, longitudinal trajectories of pre- and post- treatment changes in brain volume and disconnection in a cohort of 124 natalizumab-treated patients. Low- and high-dimensional models of the relationship between treatment and the trajectories of change were built and evaluated with machine learning, quantifying performance with receiver operating characteristic curves. Simulations of randomised controlled trials enrolling varying numbers of patients were used to quantify the impact of dimensionality on statistical efficiency. Compared to existing methods, high-dimensional models were superior in treatment response detection (area under the receiver operating characteristic curve = 0.890 [95% CI = 0.885–0.895] vs. 0.686 [95% CI = 0.679–0.693], P < 0.01]) and in statistical efficiency (achieved statistical power = 0.806 [95% CI = 0.698–0.872] vs. 0.508 [95% CI = 0.403–0.593] with number of patients enrolled = 50, at α = 0.01). High-dimensional models based on routine, clinical imaging can substantially enhance the detection of the imaging response to treatment in multiple sclerosis, potentially enabling more accurate individual prediction and greater statistical efficiency of randomised controlled trials.
Analysis of operating conditions of a cooling installation with carbon dioxide
Authors: Bieniek Artur , Mika Łukasz , Kuchmacz Jan 
Published: June 2019

In response to international regulations, natural refrigerants
such as carbon dioxide are more and more frequently used in the refrigeration industry. Due to thermodynamic properties, R-744 is used in the transcritical cycle as an individual refrigerant. In the hereby article, high pressure of CO2 and air temperature values were analysed. The measurements were conducted on the gas cooler side and involved external air temperature values in the summer period between 1 June to 30 September 2018. The “Booster” installation was used in one of Polish supermarkets. Correlations required to determine the optimal pressure of carbon dioxide depending on ambient temperature were presented in the article. The equations presented hereby allowed to maximize the energy efficiency ratio. An optimal high pressure for one of the correlations from literature was calculated on the basis of the measurement of ambient temperature. Actual and optimal pressure values of carbon dioxide were compared in the analysed period of time.
Pre-eclampsia/Eclampsia
Authors: Peraçoli José Carlos , Borges Vera Therezinha Medeiros , Ramos José Geraldo Lopes , Cavalli Ricardo de Carvalho , Costa Sérgio Hofmeister de Almeida Martins , Oliveira Leandro Gustavo de , Souza Francisco Lazaro Pereira de , Korkes Henri Augusto , Brum Ione Rodrigues , Costa Maria Laura , Corrêa Junior Mário Dias , Sass Nelson , Diniz Angélica Lemos Debs , Prado Caio Antonio de Campos , Cunha Filho Edson Viera da 
Published: June 2019

AbstractPre-eclampsia is a multifactorial and multisystemic disease specific to gestation. It is classically diagnosed by the presence of hypertension associated with proteinuria manifested in a previously normotensive pregnant woman after the 20th week of gestation. Pre-eclampsia is also considered in the absence of proteinuria if there is target organ damage. The present review takes a general approach focused on aspects of practical interest in the clinical and obstetric care of these women. Thus, it explores the still unknown etiology, current aspects of pathophysiology and of the diagnosis, the approach to disease prediction, its adverse outcomes and prevention. Management is based on general principles, on nonpharmacological and on pharmacological clinical treatment of severe or nonsevere situations with emphasis on the hypertensive crisis and eclampsia. Obstetric management is based on preeclampsia without or with signs of clinical and/or laboratory deterioration, stratification of gestational age in < 24 weeks, between 24 and less than 34 weeks, and ≥ 34 weeks of gestation, and guidance on route of delivery. An immediate puerperium approach and repercussions in the future life of pregnant women who develop preeclampsia is also presented.
Cirugía de rescate en el síndrome del túnel del carpo: nuestra experiencia utilizando el colgajo vascularizado de grasa hipotenar
Authors: Almoguera-Martinez Alejandro , Martinez-Perez Irene , Jiménez Lydia Alcázar , Valmaña José María De la Sotilla , Martínez María Ángeles Calvo , Plasencia Miguel Ángel Arriba 
Published: June 2019

Introducción Una de las técnicas más extendidas para tratar la recidiva del síndrome del túnel del carpo (STC), es la interposición de un colgajo de almohadilla grasa hipotenar vascularizada (técnica de Strickland). Esa técnica es la empleada por la Unidad de Cirugía de Muñeca y Mano del Servicio de Traumatología del Hospital Universitario Príncipe de Asturias. El objetivo de este estudio, es revisar los pacientes intervenidos de recidiva del STC en dicha unidad mediante esa técnica, y comprobar su evolución a medio y largo plazo.
Material y Método En este trabajo se lleva a cabo un estudio retrospectivo de tipo descriptivo. La población estudiada es la muestra de pacientes operados mediante la técnica de Strickland, para la recidiva del STC, intervenidos entre el 2010 y el 2017, habiendo pasado un mínimo de 6 meses desde esa última intervención.
Conclusión Pese a las limitaciones de este estudio, los datos avalan que se obtiene mejoría objetiva y subjetiva en un número elevado de pacientes con STC recidivado: al menos el 50% de los pacientes intervenidos se encuentran satisfechos; siendo bajo el índice de complicaciones.
Capitolunate Arthrodesis versus Four-corner Arthrodesis in Scaphoin Nonunion Advanced Collapsed Wrist Treatment
Authors: González Porto Sara Alicia , Cano Leira María Ángeles , González Rodríguez Alba , Álvarez Jorge Ángel 
Published: June 2019

Objective To evaluate the outcomes of scaphoidectomy and capitolunate arthrodesis versus four-corner arthrodesis in patients with stage III scaphoid nonunion advanced collapse (SNAC) wrists.
Methods We reviewed retrospectively all of the consecutive patients surgically treated in our center between 2007 and 2015, including 20 patients in the four-corner arthrodesis group and 11 patients in the capitolunate group. The mean follow-up time was of 47 months. The follow-up evaluation included wrist range of motion (ROM), grip strength, visual analogue scale (VAS), the disabilities of the arm, shoulder, and hand (DASH) questionnaire, and the Mayo wrist scale (MWS). Postoperative complications and the radiographic evaluation were also assessed.
Results There was no statistical difference in flexion, radial deviation, ulnar deviation, grip strength, VAS, DASH or MWS scores. There was a statistically significant increase (6°) in extension in capitolunate arthrodesis versus four-corner arthrodesis, possibly without clinical relevance. There were two nonunions in the four-corner group, and none in the capitolunate group. None of the patients in the capitolunate group required screw removal. One patient in the four-corner group required dorsal plate removal. One patient in each group required conversion to total arthrodesis.
Conclusions Capitolunate arthrodesis shows similar results in wrist ROM, grip strength and patient-reported outcomes when compared with four-corner arthrodesis at an average follow-up period of 4 years. We did not have any pisotriquetral arthritis in the capitolunate arthrodesis group, despite not removing the triquetrum in any of patients of this group.
Type of study/level of evidence Therapeutic III.
Diffusion Tensor Imaging for Surgical Planning in Patients with Cervical Spondylotic Myelopathy
Authors: Schöller Karsten , Siller Sebastian , Brem Christian , Lutz Jürgen , Zausinger Stefan 
Published: June 2019

Abstract
Background and Study Aims/Objective Despite its invasiveness, computed tomography myelography (CTM) is still considered an important supplement to conventional magnetic resonance imaging (MRI) for preoperative evaluation of multilevel cervical spondylotic myelopathy (CSM). We analyzed if diffusion tensor imaging (DTI) could be a less invasive alternative for this purpose.
Material and Methods In 20 patients with CSM and an indication for decompression of at least one level, CTM was performed preoperatively to determine the extent of spinal canal/cerebrospinal fluid (CSF) space and cord compression (Naganawa score) for a decision on the number of levels to be decompressed. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were correlated with these parameters and with MRI-based increased signal intensity (ISI). Receiver operating characteristic analysis was performed to determine the sensitivity to discriminate levels requiring decompression surgery. European Myelopathy Score (EMS) and neck/radicular visual analog scale (VAS-N/R) were used for clinical evaluation.
Results According to preoperative CTM, 20 levels of maximum and 16 levels of relevant additional stenosis were defined and decompressed. Preoperative FA and particularly ADC showed a significant correlation with the CTM Naganawa score but also with the ISI grade. Furthermore, both FA and ADC facilitated a good discrimination between stenotic and nonstenotic levels with cutoff values < 0.49 for FA and > 1.15 × 10−9 m2/s for ADC. FA and especially ADC revealed a considerably higher sensitivity (79% and 82%, respectively) in discriminating levels requiring decompression surgery compared with ISI (55%). EMS and VAS-N/R were significantly improved at 14 months compared with preoperative values.
Conclusion DTI parameters are highly sensitive at distinguishing surgical from nonsurgical levels in CSM patients and might therefore represent a less invasive alternative to CTM for surgical planning.
Characterization of AtWRI1 in fatty acids and starch synthesis in rice
Authors: Yang Junxing , Tian Rongcai , Gao Zhiqiang , Yang Huibing 
Published: June 2019

ABSTRACT
WRINKLED1 (WRI1) belongs to AP2/EREBP transcription factor. Its function in dicots for fatty acids synthesis has been deeply studied, but its role in monocot, especially in rice, is still poorly understood. Here, with the overexpression of AtWRI1 in rice, we found its overexpression increased fatty acids content in vegetative organs and seed coat including aleurone layer (SCAL) but decreased fatty acids content in endosperm. Meanwhile, the overexpression of AtWRI1 increased starch content in endosperm. These results provide a new insight into the function of AtWRI1in monocot and make a previous basement for the study of the connection of fatty acids and starch synthesis in rice.
Adenosine A2A receptor deficiency prevents p38MAPK activation and apoptosis of mouse hippocampal cells in the chronic hypoxic-hypercapnia model
Authors: Ren Huiming , Guo Xu , Wang Xiaotong , Cui Zhihui 
Published: June 2019

ABSTRACT
This study aims to study the effects of adenosine A2A receptor (A2AR) on hippocampal cell apoptosis and the putative mechanisms in a mouse model of chronic hypoxic-hypercapnia. Wild-type (WT) or A2AR knockout (A2AR KO) mice were randomly divided into normal control (NC) groups and chronic hypoxic-hypercapnia (4HH) groups. Compared with their corresponding NC groups (WT-NC and KO-NC), the apoptosis index (AI), caspase-3 activity, Bax mRNA and P-p38 protein expression in the hippocampus of 4HH groups (WT-4HH and KO-4HH) were significantly increased, while Bcl2 mRNA expression was significantly decreased (P &lt; 0.05). Moreover, A2AR deficiency significantly rescued the effect of chronic hypoxic-hypercapnia on apoptosis when compared with the WT-4HH group (P &lt; 0.05). A2AR deficiency inhibits hippocampal cell apoptosis in mice exposed to chronic hypoxic-hypercapnia, which might be associated with dampened p38 MAPK activation and Bax mRNA expression, and augmented Bcl-2 mRNA expression.
A method for aligning the plastic scintillator detector on DAMPE
Authors: Ma Peng-Xiong , Zhang Yong-Jie , Zhang Ya-Peng , Li Yao , Zang Jing-Jing , Li Xiang , Dong Tie-Kuang , Fan Yi-Zhong , Lei Shi-Jun , Wu Jian , Yu Yu-Hong , Yuan Qiang , Yue Chuan , Sun Zhi-Yu 
Published: June 2019

Abstract
The Plastic Scintillator Detector (PSD) onboard the DArk Matter Particle Explorer (DAMPE) is designed to measure cosmic ray charge (Z) and to act as a veto detector for gamma ray identification. To fully exploit the charge identification potential of PSD and to enhance its capability to identify gamma ray events, we develop an alignment method for the PSD. The path length of a given track in the volume of a PSD bar is derived taking into account the shift and rotation alignment corrections. By examining energy spectra of corner-passing events and fully contained events, position shifts and rotations of all PSD bars are obtained, and are found to be on average about 1mm and 0.0015 radian respectively. To validate the alignment method, we introduce artificial shifts and rotations of PSD bars into the detector simulation. These shift and rotation parameters can be recovered successfully by the alignment procedure. As a result of the PSD alignment procedure, the charge resolution of the PSD is improved from 4% to 8%, depending on the nuclei.