bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐Term Clinical Outcomes of Late Stent Malapposition Detected by Optical Coherence Tomography After Drug‐Eluting Stent Implantation
Authors: Im Eui , Hong Sung‐Jin , Ahn Chul‐Min , Kim Jung‐Sun , Kim Byeong‐Keuk , Ko Young‐Guk , Choi Donghoon , Jang Yangsoo , Hong Myeong‐Ki 
Published: March 2019

Background

The relationship between late stent malapposition (
LSM
) and adverse cardiovascular events is controversial. Studies are needed to evaluate long‐term (>5 years) clinical outcomes of LSM detected by optical coherence tomography (
OCT
) after drug‐eluting stent implantation.

Methods and Results

We investigated long‐term clinical outcomes of
OCT
‐detected
LSM
in 351 patients who received drug‐eluting stents and were examined by both poststent and follow‐up
OCT
(175±60 days after drug‐eluting stent implantation) from January 2009 to December 2011.
LSM
was observed in 99 patients (28%). We evaluated the cumulative rate of composite events (cardiovascular death, target‐vessel–related myocardial infarction, target‐vessel revascularization, and stent thrombosis). During 80.1±24.5 months of follow‐up, very late stent thrombosis did not occur in any patients with
LSM
. The cumulative 8‐year rate of composite events was 7.3% in patients with
LSM
and 10.5% in patients without
LSM
(
P
=0.822, log‐rank test). We further divided patients into the following 4 groups: patients with both late‐persistent and late‐acquired stent malapposition (n=23), patients with late‐persistent stent malapposition alone (n=45), patients with late‐acquired stent malapposition alone (n=31), and patients without
LSM
(n=252). The cumulative 8‐year rates of composite events were similar among these 4 groups (0%, 9.6%, 9.7%, and 10.5%, respectively;
P
=0.468 by log‐rank test).

Conclusions

During long‐term follow‐up (>5 years), very late stent thrombosis did not occur in patients with
OCT
‐detected
LSM
. The rates of adverse clinical events were similar between patients with
LSM
versus those without
LSM
. Presence of
OCT
‐detected
LSM
was not associated with unfavorable clinical outcomes.
MyDiaText™: Feasibililty and Functionality of a Text Messaging System for Youth With Type 1 Diabetes
Authors: Kaushal Tara , Montgomery Kathleen A. , Simon Reid , Lord Kelly , Dougherty Jennifer , Katz Lorraine E. Levitt , Lipman Terri H. 
Published: March 2019

Purpose The purpose of this study was to determine the feasibility and functionality of MyDiaText™, a website and text messaging platform created to support behavior change in adolescents with type 1 diabetes (T1DM) and to evaluate user satisfaction of the application. Methods This study was a nonrandomized, prospective, pilot trial to test the feasibility and user interface with MyDiaText, a text message system for 10- to 17-year-old youths with newly diagnosed T1DM. Feasibility was evaluated by assessing for the user’s ability to create a profile on the website. Functionality was defined by assessing whether a subject responded to at least 2 text messages per week and by their accumulating points on the website. User satisfaction of the text messaging system was assessed using an electronic survey. The 4 phases of this study were community engagement—advisory sessions, screening and enrollment, intervention, and follow-up. Results Twenty subjects (14 male, 6 female) were enrolled. All subjects were able to create a profile, and of these, 86% responded to at least 2 text messages per week. A survey administered during follow-up showed that users enjoyed reading text messages, found them useful, and thought the frequency of messages was appropriate. Conclusion MyDiaText is a feasible, functional behavioral support tool for youth with T1DM. Users of the application reported high satisfaction with text messages and the reward system.
Prevalence of Neuropathic Pain Symptoms in Foot and Ankle Patients
Authors: Sidon Eliezer , Rogero Ryan , McDonald Elizabeth , Daecher Annemarie , Shakked Rachel , Pedowitz David I. , Fuchs Daniel , Daniel Joseph N. , Raikin Steven M. 
Published: March 2019

Background: The management of pain in patients with foot and ankle pathology can be challenging. Cumulative data suggest that, in addition to nociceptive mechanisms, other neuropathic mechanisms can contribute to pain in a subset of people with orthopedic conditions, and can be found in 10.5% to 53% of patients with chronic pain, depending on the location of the pathology. Preoperative diagnosis of neuropathic pain (NP) can potentially change decision making and management of foot and ankle pathologies. Methods: We used a validated patient-reported pain questionnaire (painDETECT) as a cross-sectional study to investigate the prevalence of NP symptoms in a population of patients undergoing foot and ankle surgery. A total of 533 patients were prospectively included and completed the painDETECT questionnaire. Results: Sixty-six patients (12.4%) were classified as having a component of NP symptoms according to their painDETECT score. Current smokers (23.2%) had a significantly higher rate of developing NP symptoms than current nonsmokers (11.1%) ( P = .016). The location of the pathology and obesity had a moderate effect on the prevalence of NP symptoms. Patients with ankle-level pathology, excluding tarsal tunnel syndrome, had a marginally increased risk of having NP symptoms (15.4%) compared to patients with forefoot pathologies, excluding Morton’s neuroma (7.5%, P = 0.06). Obesity also had a moderate effect on the NP risk, with 15.6% risk of NP symptoms for patients with BMI of 30 or more compared to 10% risk for patients with a BMI of less than 30 ( P = .06). Patients with NP symptoms reported significantly higher levels of current pain (7.2 vs 4.6, P < .001). Conclusion: A considerable number of patients with foot and ankle problems requiring surgery had a neuropathic component of pain. Evaluation of their risk factors and level of pain may help with the diagnosis, decision making, and pain control. Further research is needed to evaluate the effect of preoperative NP on the short- and long-term results of surgeries. Level of Evidence: Level II, prospective cohort survey study.
Measurement of Dorsal First Ray Mobility: A Topical Historical Review and Commentary
Authors: Glasoe Ward M. , Michaud Thomas C. 
Published: March 2019

Despite evidence that instability of the first ray (first metatarsal and medial cuneiform) alters the loading mechanics of the foot, surprisingly few studies have linked the condition with disorders of the foot. A factor limiting this research is the difficulty associated with measuring first ray mobility (FRM). To quantify dorsal FRM, clinicians and researchers have devised a variety of methods that impose a dorsally directed load, and record displacement. The methods include manual examination, radiographs, mechanical devices, and handheld rulers. Since different methods yield different results; each of these methods is worthy of scrutiny. This article reviews the methods used to quantify dorsal FRM and offers commentary on how the testing procedures could be standardized. The measurement of dorsal FRM informs surgical decisions, orthotic prescriptions, and research design strategies mostly as it pertains to the identification and treatment of first ray hypermobility. This review found sufficient support to recommend continued use of radiographs and mechanical devices for quantifying dorsal displacement, whereas measurements acquired with handheld rulers are prone to the same subjective error attributed to manual examination procedures. Since measures made with radiographs and existing mechanical devices have their own drawbacks, the commentary recommends ideas for standardizing the testing procedure and calls for the development of a next-generation device to measure dorsal FRM. This future device could be modeled after arthrometers that exist and are used to quantify stability at the knee and ankle. Level of Evidence: Level V, expert opinion.
Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline
Authors: LeRoith Derek , Biessels Geert Jan , Braithwaite Susan S , Casanueva Felipe F , Draznin Boris , Halter Jeffrey B , Hirsch Irl B , McDonnell Marie E , Molitch Mark E , Murad M Hassan , Sinclair Alan J 
Published: March 2019

AbstractObjectiveThe objective is to formulate clinical practice guidelines for the treatment of diabetes in older adults.ConclusionsDiabetes, particularly type 2, is becoming more prevalent in the general population, especially in individuals over the age of 65 years. The underlying pathophysiology of the disease in these patients is exacerbated by the direct effects of aging on metabolic regulation. Similarly, aging effects interact with diabetes to accelerate the progression of many common diabetes complications. Each section in this guideline covers all aspects of the etiology and available evidence, primarily from controlled trials, on therapeutic options and outcomes in this population. The goal is to give guidance to practicing health care providers that will benefit patients with diabetes (both type 1 and type 2), paying particular attention to avoiding unnecessary and/or harmful adverse effects.
Novel refractive LiDAR sensor based on a variable lens pair prism
Authors: Baier Matthias , Sparbert Jan , Neumann Cornelius 
Published: March 2019

Abstract
We present a new type of Light Detection And Ranging (LiDAR) sensor based on a variable lens pair prism. This system combines the principles of macro- and microscanners to exploit the advantages and eliminate most of the disadvantages of both system types. We describe the concept of this new LiDAR sensor and examine the system performance by simulation. Afterwards, we investigate the spot shape and beam profile with respect to the main system parameters such as the gap between lenses, the deflection angle, and the measurement distance. Furthermore, we present solutions to optimize the variable lens pair prism to achieve an ideal spot shape and beam profile in the entire field of view (FoV).
Do Immigrants Compete with Natives in the Greek Labour Market? Evidence from the Skill-Cell Approach before and during the Great Recession
Authors: Chletsos Michael , Roupakias Stelios 
Published: March 2019

Abstract
We attempt to identify the impact of immigration on the labour market opportunities of resident workers by analysing data from the Greek Labour Force Survey (1999–2015) as well as census data for 1981, 1991, and 2001. Slicing the national labour market into education and experience segments, we find modest adverse effects on the employment outcomes of natives and usually insignificant effects on earnings. Our results are generally robust to alternative definitions of skill groups and the potential “downgrading” of immigrants. Importantly, we obtain similar results in qualitative terms when we account for potential endogenous selection into skill-cells, by implementing an instrumental variables approach in the spirit of Card (2001). We also show that veteran immigrants compete more heavily with natives than recent immigrants do. In addition, our analysis indicates that the effects of immigration were economically more important during the Greek crisis. Finally, the evidence supports the idea that migrants push natives towards complementary, non-routine tasks.
On Lawyer Compensation When Appeals Are Possible
Authors: At Christian , Friehe Tim , Gabuthy Yannick 
Published: March 2019

Abstract
This paper describes how plaintiff should compensate lawyers, who choose unobservable effort, when litigation may proceed from the trial to the appeals court. We find that, when it is very likely that the defendant will appeal, transfers made to the lawyer only after an appeals court’s ruling are key instruments in incentivizing both trial and appeal court effort. Indeed, the lawyer may not receive any transfer after the trial court’s ruling. In contrast, when reaching the appeals stage is unlikely, a favorable trial court ruling triggers a positive transfer to the lawyer and first-best appeals effort. In our setup, the lawyer may receive a lower transfer after winning in both the trial and the appeals court as compared to the scenario in which the first-instance court ruled against the plaintiff and the appeals court reversed that ruling.
The association between activated protein C ratio and Factor V Leiden are gender-dependent
Authors: Hansen Rasmus Søgaard , Nybo Mads 
Published: March 2019

Abstract

Background
The most common cause of activated protein C (aPC) resistance is a missense substitution (Arg506Gln), known as Factor V Leiden (FVL). Due to its low cost, many laboratories use the aPC ratio as a primary test with a unisex cut-off. However, the association between the aPC ratio and FVL including any relation to gender has been sparsely investigated.

Methods
Results of the aPC ratio and FVL analyses from 1081 patients referred to the Thrombophilia Clinic at Odense University Hospital were compared.

Results
In 153 FVL positive patients, the mean aPC ratio was 2.1 ± 0.3, which differed from 2.7 ± 0.4 in FVL negative individuals (p < 0.01). The receiver operating characteristics (ROC), with area under the curve (AUC) of 0.93, indicated the optimal aPC cut-off at 2.3–2.4, with sensitivity 89%–94%, specificity 71%–84%, positive predictive value 35%–48% and negative predictive value 98%–99%. In FVL positive females, the mean aPC ratio was 2.0 ± 0.3, which differed from males (2.1 ± 0.3, p < 0.05). In FVL negative females, the mean aPC ratio was 2.6 ± 0.4, also different from males (2.8 ± 0.5, p < 0.01). Of note, 35% of FVL negative females had an aPC ratio ≤2.4 against 18% in males (p < 0.01).

Conclusions
Our results indicate that the aPC ratio is lower in females than in males. Due to a high negative predictive value the aPC ratio can be used as a first line test for FVL, but those found positive must be confirmed with a DNA test.
Design and implementation of quality control plans that integrate moving average and internal quality control: incorporating the best of both worlds
Authors: van Rossum Huub H. , van den Broek Daan 
Published: March 2019

Abstract

Background
New moving average quality control (MA QC) optimization methods have been developed and are available for laboratories. Having these methods will require a strategy to integrate MA QC and routine internal QC.

Methods
MA QC was considered only when the performance of the internal QC was limited. A flowchart was applied to determine, per test, whether MA QC should be considered. Next, MA QC was examined using the MA Generator (www.huvaros.com), and optimized MA QC procedures and corresponding MA validation charts were obtained. When a relevant systematic error was detectable within an average daily run, the MA QC was added to the QC plan. For further implementation of MA QC for continuous QC, MA QC management software was configured based on earlier proposed requirements. Also, protocols for the MA QC alarm work-up were designed to allow the detection of temporary assay failure based on previously described experiences.

Results
Based on the flowchart, 10 chemistry, two immunochemistry and six hematological tests were considered for MA QC. After obtaining optimal MA QC settings and the corresponding MA validation charts, the MA QC of albumin, bicarbonate, calcium, chloride, creatinine, glucose, magnesium, potassium, sodium, total protein, hematocrit, hemoglobin, MCH, MCHC, MCV and platelets were added to the QC plans.

Conclusions
The presented method allows the design and implementation of QC plans integrating MA QC for continuous QC when internal QC has limited performance.
Diagnostic accuracy of a fully automated multiplex celiac disease antibody panel for serum and plasma
Authors: Terryberry Jeff , Tuomi Jani , Perampalam Subo , Peloquin Russ , Brouwer Eric , Schuppan Detlef , Guandalini Stefano 
Published: March 2019

Abstract

Background
An automated multiplex platform using capillary blood can promote greater throughput and more comprehensive studies in celiac disease (CD). Diagnostic accuracy should be improved using likelihood ratios for the post-test probability of ruling-in disease.

Methods
The Ig_plex™ Celiac Disease Panel on the sqidlite™ automated platform measured IgA and IgG antibodies to tTG and DGP in n = 224 CD serum or plasma samples. Diagnostic accuracy metrics were applied to the combined multiplex test results for several CD populations and compared to conventional single antibody ELISA tests.

Results
With multiple positive antibody results, the post-test probability for ruling-in untreated and treated CD increased to over 90%. The number of samples positive for more than one antibody also increased in untreated CD to ≥90%. Measurement of all four CD antibodies generate cut-off dependent accuracy profiles that can monitor response to treatment with the gluten-free diet (GFD). Higher positive tTG and DGP antibodies are seen more frequently in confirmed CD without (81%–94%) than with GFD treatment (44%–64%). In CD lacking biopsy confirmation, overall agreement of plasma to serum was ≥98% for all antibodies, and 100% for venous to capillary plasma.

Conclusions
The Ig_plex Celiac Disease Panel increases the likelihood of confirming CD based on the post-test probability of disease results for multi-reactive markers. Specific positivity profiles and cut-off intervals can be used to monitor GFD treatment and likely disease progression. Using serum, venous and capillary plasma yield comparable and accurate results.
Commutability of reference and control materials: an essential factor for assuring the quality of measurements in Laboratory Medicine
Authors: Braga Federica , Panteghini Mauro 
Published: March 2019

Abstract
Traceability to a common reference ensures equivalence of results obtained by different assays. Traceability is achieved by an unbroken sequence of calibrations, using reference materials (RMs) that must be commutable. Using non-commutable RMs for calibration will introduce a bias in the calibrated method producing incorrect results for clinical samples (CS). Commutability was defined in 1973 as “the ability of an enzyme material to show inter-assay activity changes comparable to those of the same enzyme in human serum” and later extended as a characteristic of all RMs. However, the concept is still poorly understood and appreciated. Commutability assessment has been covered in CLSI guidelines and requires: (a) selection of 20 CS spanning the relevant concentration range; (b) analysis of both RM and CS with the pair of procedures; (c) data elaboration using regression analysis and calculation if RM fall within the 95% prediction interval defined by CS. This approach has been criticized and to improve it The International Federation of Clinical Chemistry and Laboratory Medicine established a working group that recently finalized recommendations. Commutability is also a requirement for the applicability of external quality assessment (EQA) results in the evaluation of the performance of participating laboratories in terms of standardization of their measurements. Unfortunately, EQA materials are usually not validated for commutability.
Quasi-Optimality of Adaptive Mixed FEMs for Non-selfadjoint Indefinite Second-Order Linear Elliptic Problems
Authors: Carstensen Carsten , Dond Asha K. , Rabus Hella 
Published: March 2019

Abstract
The well-posedness and the a priori and a posteriori error analysis of the lowest-order Raviart–Thomas
mixed finite element method (MFEM) has been established for non-selfadjoint
indefinite second-order linear elliptic problems recently in an article by Carstensen, Dond, Nataraj
and Pani (Numer. Math., 2016). The associated adaptive mesh-refinement strategy faces
the difficulty of the flux error
control in

H
⁢

(
div
,
Ω
)

{H({\operatorname{div}},\Omega)}

and so involves a data-approximation error

∥

f
-

Π
0

⁢
f

∥

{\lVert f-\Pi_{0}f\rVert}

in the

L
2

{L^{2}}

norm of the right-hand side f and its piecewise constant approximation

Π
0

⁢
f

{\Pi_{0}f}

. The separate marking strategy has recently been suggested
with a split of a Dörfler marking for the remaining error estimator and an optimal data approximation strategy
for the appropriate treatment of

∥

f
-

Π
0

⁢
f

∥

L
2

⁢

(
Ω
)

{\|f-\Pi_{0}f\|_{L^{2}(\Omega)}}

.
The resulting strategy presented in this paper
utilizes the abstract algorithm and convergence analysis of
Carstensen and Rabus (SINUM, 2017) and generalizes it to general second-order
elliptic linear PDEs. The argument for the treatment of the piecewise constant displacement approximation

u
RT

{u_{{\mathrm{RT}}}}

is its supercloseness to the piecewise constant approximation

Π
0

⁢
u

{\Pi_{0}u}

of the exact displacement u. The overall convergence analysis then indeed follows the axioms of adaptivity for separate marking.
Some results on mixed and nonconforming
finite element approximations on the multiply connected polygonal 2D Lipschitz domain
are of general interest.
Qualitative Protest- und Bewegungsforschung
Authors: Gukelberger Sandrine , Gerharz Eva 
Published: March 2019

Abstract
Der erste Beitrag des Forschungsjournals 1/2019 mit dem Titel Hinschauen mit Verständnis. Methoden und Ethik der globalen Bewegungsforschung diskutiert unterschiedliche qualitative Zugänge der Protest und Bewegungsforschung und ihre spezifischen methodologischen und methodischen Herangehensweisen. Insbesondere werden der Aufbau von kooperativen Forschungsbeziehungen, der Umgang mit dem Eigenen und dem Fremden und die Schwierigkeiten des Verstehens in heterogenen sozialen Feldern thematisiert. Zu Beginn stellen Sandrine Gukelberger und Eva Gerharz den Mehrwert qualitativer Perspektiven in der Bewegungsforschung dar, um uns in einem nächsten Schritt mit den praktischen Herausforderungen des Datenerhebungsprozesses und der Problematik der Repräsentation zu befassen. Im Zentrum stehen die variierenden Machtbalancen zwischen Forschenden und Forschungspartner*innen und die Frage, wie diese Datenerhebung und Analyse strukturieren. Hierzu gehören auch ethische Fragen, die den Umgang mit den Daten und den Forschungsergebnissen betreffen. Der Artikel schließt mit einem Plädoyer für die Vorteile qualitativer Forschungsperspektiven auf Protest, Aktivismus und Bewegungen. Denn das Potenzial der qualitativen Perspektiven, die soziale Realität ‚von unten‘ rekonstruieren, liegt gerade darin, die Rolle von sozialem und politischem Handeln inmitten komplexer ökonomischer, sozialer und politischer Transformationsprozesse herauszuarbeiten und besser zu verstehen.
Rekonstruktive Zugänge zu Protest
Authors: Betz Gregor J. 
Published: March 2019

AbstractGanzheitliche, ethnographische und rekonstruierende Forschung setzt stets voraus, sich mit den spezifischen Erhebungsbedingungen des jeweils zu untersuchenden Gegenstands zu befassen. Die konkreten Voraussetzungen für die Erforschung politischen Protests werden in vorliegendem Aufsatz methodologisch und methodisch reflektiert. Zunächst wird politischer Protest als Gegenstand sozialwissenschaftlicher Forschung grundsätzlich eingeordnet und basierend auf einer Definition der Zugang zu Protestereignissen diskutiert. Daran anschließend werden zwei idealtypische Formationen der Vergemeinschaftung vorgestellt. Die zwei Typen unterscheiden sich dadurch, ob sie externe Personen ausgrenzen oder einschließen, was wiederum Konsequenzen auf den Feldzugang hat. Abschließend wird der typische Verlauf – das Trajekt – eines Projektereignisses dargelegt und methodische Schlussfolgerungen daraus gezogen.