bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Subset of Paracrine Factors as Efficient Biomarkers for Predicting Vascular Regenerative Efficacy of Mesenchymal Stromal/Stem Cells
Authors: Kim Hyun-Kyung , Lee Seul-Gi , Lee Seung-Woo , Oh Bae Jun , Kim Jae Hyeon , Kim Jeong A. , Lee Guisera , Jang Jae-Deog , Joe Young Ae 
Published: October 2018

AbstractMesenchymal stromal/stem cells (MSCs) have been developed as a promising source for cell-based therapies of ischemic disease. However, there are some hurdles in their clinical application such as poor cell engraftment and inconsistent stem cell potency. In this study, we sought to find biomarkers for predicting potency of MSCs for proangiogenic therapy to improve their beneficial effects. Large variations were observed in proangiogenic factor secretion profiles of conditioned media derived from nine different donor-derived Wharton's jelly (WJ)-derived MSCs and 8 factors among 55 angiogenesis-related factors were secreted at considerable levels. Two distinct WJ-MSCs that had the lowest or the highest secretion of these eight factors showed corresponding proangiogenic activities in in vitro angiogenesis assays. When four additional different donor-derived WJ-MSCs were further examined, proangiogenic activities in migration and tube formation of endothelial cells and in in vivo Matrigel plug assay were highly consistent with secretion levels of four major factors (angiogenin, interleukin-8, monocyte chemoattractant protein-1, and vascular endothelial growth factor). Such correlation was also observed in vascular regenerative effect in a mouse hind limb ischemia model. Blocking of these four factors by neutralizing antibodies or knockdown of them by siRNA treatment resulted in significant inhibition of proangiogenic activities of not only WJ-MSCs, but also bone marrow-derived MSCs. These results suggest that these four factors may represent efficient biomarkers for predicting vascular regenerative efficacy of MSCs. Stem Cells 2019;37:77–88
The practical CT transient simulation model based on dynamic tests and its application
Authors: Qi Xuanwei , Ye Yutian , Wang Song , Lu Chengyu , Xuan Xiaohua , Wen Minghao 
Published: October 2018

AbstractWith the fast development of the modern power system, the current transformer (CT) saturation problem is most serious, causing the measuring error of primary current and the maloperation of protection. This article proposes a CT transient simulation model based on the Jiles–Atherton theory. The key coefficients of the CT model that define the basic magnetizing characteristics are identified based on the practical CT. The dynamic tests are carried out to analyze the saturation characteristics of different CT types, and to verify the accuracy of the CT simulation model. The CT simulation models are then utilized for analyzing two actual maloperation cases. The results prove that the proposed CT simulation model can provide an effective method for analyzing the CT saturation problem. © 2018 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Delusions and Three Myths of Irrational Belief
Authors: Bortolotti Lisa 
Published: October 2018

AbstractThis chapter addresses the contribution that the delusion literature has made to the philosophy of belief. Three conclusions will be drawn: (1) a belief does not need to be epistemically rational to be used in the interpretation of behaviour; (2) a belief does not need to be epistemically rational to have significant psychological or epistemic benefits; (3) beliefs exhibiting the features of epistemic irrationality exemplified by delusions are not infrequent, and they are not an exception in a largely rational belief system. What we learn from the delusion literature is that there are complex relationships between rationality and interpretation, rationality and success, and rationality and knowledge.
Direct CP violation in Cabibbo-favored charmed meson decays and ϵ′/ϵ in SU(2)L × SU(2)R × U(1)B−L model
Authors: Haba Naoyuki , Umeeda Hiroyuki , Yamada Toshifumi 
Published: October 2018

Abstract

Since the standard model contribution is virtually absent, any observation of direct CP violation in the Cabibbo-favored charmed meson decays would be evidence of new physics. In this paper, we conduct a quantitative study on direct CP violation in D
0 → K
−
π
+, D

s

+
→ ηπ
+ and D

s

+
→ η′π
+ decays in the SU(2)
L
×SU(2)
R
×U(1)
B−L
gauge extension of the standard model. In the model, direct CP violation arises mainly from the interference between the decay amplitude coming from the SM left-left current operators and that from the right-right current operators induced by W

R

+
gauge boson exchange. Interestingly, the strong phase between the two amplitudes is evaluable, since it stems from difference in QCD corrections to the left-left and right-right current operators, which is a short-distance QCD effect given by

$$ \sim \left({\alpha}_s\left({M}_{W_L}^2\right)/4\pi \right) \log \left({M}_{W_R}^2/{M}_{W_L}^2\right) $$

∼

α
s

M

W
L

2

/
4
π

log

M

W
R

2

/

M

W
L

2

. We assess the maximal direct CP violation in the above decays in the SU(2)
L
× SU(2)
R
× U(1)
B−L
model. Additionally, we present a correlation between direct CP violation in these modes and one in K → ππ decay parametrized by ϵ′, since W

R

+
gauge boson has a sizable impact on the latter.
Reduction of Risk Factors for Pedophilic Sexual Offending
Authors: Engel Jannis , Körner Mandy , Schuhmann Petya , Krüger Tillmann H.C. , Hartmann Uwe 
Published: October 2018

Abstract

Introduction
Exploratory analysis of characteristics and reduction of risk factors for child sexual abuse (CSA) in a sample treated in the Prevention Projects Dunkelfeld Hannover and Regensburg.

Aim
To evaluate a treatment program aimed at reducing dynamic risk factors (DRF) for CSA.

Methods
Using a psychometric test battery based on self-report questionnaires, intergroup analysis between treatment group (TG, n = 35), treatment refusers (TR, n = 51), and drop-out group (DO, n = 14) was conducted with pretreatment data. Intragroup analysis compared data of TG from pre- and posttreatment. The test battery included sociodemographic and sociosexual data, as well as questionnaires measuring DRF.

Main Outcome Measure
This study investigated effects of treatment on pedophilic men who are at risk for offending and observed reductions in important risk factors for CSA.

Results
TG, TR (consisting of persons who were offered but refused therapy), and DO did not differ regarding sociodemographic and sociosexual variables before therapy. There were no significant differences in education, relationship status, living solitarily, and being a father/stepfather. TR and DO lived farther away from treatment site than TG. In the TG, a reduction in offense-supportive attitudes, coping self-efficacy deficits, and child identification were revealed at second assessment. In TG no participants started the consumption of child abuse content during the course of the study.

Clinical Implications
Future treatment concepts should focus on the reduction of empirically relevant risk factors for child sexual offending.

Strength & Limitations
The present article is the first that compares TG to TR and DO before assessment regarding DRF and sociosexual variables. Moreover, it is only the second study that investigated treatment effects on a population of pedophilic men who are at risk for offending. These preliminary findings are limited by moderate group size and a missing control group.

Conclusion
A reduction in some but not all assessed risk factors for sexual offending against minors could be seen within the time frame of therapy. Findings are in line with results from a previous evaluation study.
Art and technology: archiving video games for humanities research in university libraries
Authors: Wood Kelli , Carter David S. 
Published: October 2018

AbstractOver the past half-century video games have become a significant part of our cultural environment, in part, by leading advances in both technology and artistic innovation. In recent years librarians and researchers have recognized these games as cultural objects that require collection and curation. Developing and maintaining collections of this fast moving and somewhat ephemeral media, however, poses challenges due to constantly advancing technology and a corresponding lack of consistent terminology. This article addresses the literature and critical issues surrounding collections of video games within libraries and presents a case study of the University of Michigan’s Computer and Video Game Archive (CVGA), one of the largest academic archives of its kind. Moreover, video games are situated in a humanistic approach to the field of game studies as the article draws on the relevance of methods from art history and film studies.
Public Agendas and Policy Agendas in Three Western European Countries: A Qualitative Comparative Analysis
Authors: Pritoni Andrea 
Published: October 2018

AbstractIn any democratic system, the question of whether governments pay attention to citizens’ needs and requests represents a crucial component of democratic quality. But what conditions favour this fundamental democratic process? This article compares policy priorities identified by public opinion with the actual legislative production in Italy, Spain and the UK from 2003 to 2012. The article’s methodology is a qualitative comparative analysis (QCA) in which causal conditions are represented by politico-institutional and contextual factors, while the outcome consists of the degree of overlap between public opinion priorities and legislation. Empirical analysis shows that there are four paths leading to a correspondence in priorities: first, it is linked to the combination of high government decision-making capacity and declining citizens’ trust in government; second, it is also linked to the combination of rising citizens’ trust and low government decision-making capacity. Third and fourth, priorities also correspond where there is a simultaneous absence of both trust and elections, and in the absence of both decision-making capacity and elections, respectively.
Diet and Chronology of Neolithic-Eneolithic Cultures (from 6500 to 4700 cal BC) in the Lower Volga Basin
Authors: Vybornov A , Kulkova M , Kosintsev P , Platonov V , Platonova S , Philippsen B , Nesterova L 
Published: October 2018

ABSTRACTDuring the last several years, new multi- and single-layered archaeological sites, in which the most ancient Neolithic pottery in the Eastern Europe had been found, were excavated in the region of Lower Volga. Animal bones and organic materials were sampled from these sites for radiocarbon (14C) dating and diet investigations. The evidence from these studies suggests that the first domestic animals in the Lower Volga region appeared in the Cis-Caspian culture of the Early Eneolithic. Lipid analysis of food crusts from pottery allowed the cooked food to be characterized. The detailed chronology from Neolithic (6500–5400 cal BC) to Eneolithic (5300–4700 cal BC) cultures, as well as the diet of these ancient people, were reconstructed.
Ossicular chain mobilisation versus reconstruction in surgery for isolated malleus and/or incus fixation: systematic review and meta-analysis
Authors: Crutcher W L , Tassone P , Pelosi S 
Published: October 2018

AbstractObjectiveTo compare post-operative audiometric outcomes for the two prevailing surgical approaches for isolated malleus and/or incus fixation: ossicular mobilisation with preservation of the ossicular chain, and disruption and reconstruction of the ossicular chain.MethodsA search was conducted, in December 2016, of PubMed, Scopus, and Cumulative Index to Nursing and Allied Health Literature articles written in English. Papers presenting original data regarding post-operative audiometric outcomes in patients who underwent surgical treatment for malleus and/or incus fixation with a mobile and intact stapes were included. A risk of bias assessment was performed on the 14 selected papers and a tier system was developed. Meta-analysis was accomplished by comparing pooled rates of surgical success by chi-square test and calculating odds ratios by logistical regression. Analysis was performed using Revman5 and R software.Results and conclusionAnalysis of the literature revealed no differences in audiometric outcomes between ossicular chain mobilisation and ossicular chain reconstruction in patients with isolated malleus and/or incus fixation. A large, prospective study comparing both short- and long-term hearing results for ossicular chain mobilisation and ossicular chain reconstruction in this population may identify whether a difference in outcomes exists between the two approaches.
Wound healing after tonsillectomy – a review of the literature
Authors: Davidoss N H , Eikelboom R , Friedland P L , Santa Maria P L 
Published: October 2018

AbstractObjectiveTo summarise the available literature related to wound healing post tonsillectomy, including the stages of healing, experimental models for assessing healing (in animals and humans) and the various factors that affect wound healing.MethodsA search of the English literature was conducted using the Ovid Medline database, with the search terms ‘tonsillectomy’ or ‘tonsil’ and ‘wound healing’. Thirty-one articles that objectively assessed tonsillectomy wound healing were included for analysis.ResultsThe majority of assessments in humans investigating tonsillectomy wound healing involve serial direct clinical examinations of the oral cavity. Many patient and surgical factors have been shown to affect wound healing after tonsillectomy. There is some research to suggest that the administration of adjunctive treatment in the post-operative period may be beneficial to tonsillectomy wound healing.ConclusionWound healing post tonsillectomy has been poorly researched. Having a better understanding of the process of wound healing would allow surgeons to potentially prevent, anticipate and manage complications from the surgery that arise as part of the healing process.
Reviewing indications for panendoscopy in the investigation of head and neck squamous cell carcinoma
Authors: Noor A , Stepan L , Kao S S-T , Dharmawardana N , Ooi E H , Hodge J-C , Krishnan S , Foreman A 
Published: October 2018

AbstractBackgroundThe role of panendoscopy in the modern investigation of head and neck cancer is changing with the development of improved radiological techniques, in-office biopsy capabilities and the low rate of synchronous primary tumours. This study aimed to review the indications for panendoscopy in the investigation of newly diagnosed head and neck cancer.MethodA retrospective review was conducted of 186 patients with newly diagnosed head and neck cancer, between January 2014 and December 2015, at two tertiary centres.ResultsObtaining a tissue diagnosis was the most common indication for panendoscopy (65 per cent), followed by surgical planning including transoral robotic surgery suitability assessment (22.6 per cent), and the investigation of carcinoma of an unknown primary (11.3 per cent). Two synchronous primary tumours were identified, generating a yield of 1.1 per cent.ConclusionPanendoscopy remains integral in the assessment of transoral robotic surgery suitability. Refining indications for modern panendoscopy could reduce the need for this procedure in this cohort of patients.
Design opportunity conception using the total technology space map
Authors: Luo Jianxi , Song Binyang , Blessing Lucienne , Wood Kristin 
Published: October 2018

AbstractTraditionally, design opportunities and directions are conceived based on expertise, intuition, or time-consuming user studies and marketing research at the fuzzy front end of the design process. Herein, we propose the use of the total technology space map (TSM) as a visual ideation aid for rapidly conceiving high-level design opportunities. The map is comprised of various technology domains positioned according to knowledge proximity, which is measured based on a large quantity of patent data. It provides a systematic picture of the total technology space to enable stimulated ideation beyond the designer's knowledge. Designers can browse the map and navigate various technologies to conceive new design opportunities that relate different technologies across the space. We demonstrate the process of using TSM as a rapid ideation aid and then analyze its applications in two experiments to show its effectiveness and limitations. Furthermore, we have developed a cloud-based system for computer-aided ideation, that is, InnoGPS, to integrate interactive map browsing for conceiving high-level design opportunities with domain-specific patent retrieval for stimulating concrete technical concepts, and to potentially embed machine-learning and artificial intelligence in the map-aided ideation process.
Effect of aquaporin 3 knockdown by RNA interference on antrum formation in sheep secondary follicles cultured in vitro
Authors: Paz Marcela Pinheiro , de Sousa Francisca Geovania Canafístula , Alves Benner Geraldo , Lobo Carlos Henrique , Sales Antonia Débora , Tavares Kaio Cesar Simiano , de Sá Naíza Arcângela Ribeiro , Guerreiro Denise Damasceno , Maside Carolina , Rocha Rebeca Magalhães Pedrosa , Bertolini Luciana Relly , Bordignon Vilceu , de Figueiredo José Ricardo , Rodrigues Ana Paula Ribeiro 
Published: October 2018

SummaryThe objectives were to develop an effective protocol for transfection of ovine secondary follicles and to assess the effect of attenuating aquaporin 3 (AQP3) using a small interfering RNA (siRNA-AQP3) on antrum formation and follicular growth in vitro. Various combinations of Lipofectamine® volumes (0.5, 0.75 or 1.0 µl), fluorescent oligonucleotide (BLOCK-iT ™) concentrations (3.18, 27.12 or 36.16 nM) and exposure times (12, 14, 16, 18 or 20 h) were tested. The BLOCK-iT™ was replaced by siRNA-AQP3 in the transfection complex. Ovine secondary follicles were isolated and cultured in vitro for 6 days using standard protocols. Follicles were transfected on day 0 or 3 or on both days (0 and 3) and then cultured for an additional 3 or 6 days. As revealed by the fluorescence signal, the Lipofectamine®/BLOCK-iT™ complex (0.75 µl + 27.12 nM by 12 h of incubation) crossed the basement membrane and granulosa cell and reached the oocytes. In general, the rate of intact follicles was higher and the rate of antrum formation was lower in transfected follicles compared with control follicles. In conclusion, ovine secondary follicles can be successfully transfected during in vitro culture, and siRNA-mediated attenuation of AQP3 gene reduced antrum formation of secondary follicles.
Propensity in low-grade oocytes for delayed germinal vesicle breakdown compromises the developmental ability of sub-optimal grade Bubalus bubalis oocytes
Authors: Kumar Manish , Faraji Mona , Sarwalia Parul , Kumar Sandeep , Gohain Moloya , De Sachinandan , Kumar Rakesh , Datta T K 
Published: October 2018

SummaryMaturing oocytes have diverse developmental potential and good quality oocytes exhibit a better ability to attain physiological milestones in a time-dependent manner. This situation necessitates the confirmation of oocyte developmental status more precisely under an in vitro embryo production (IVEP) regime. The aim of this study was to explain timely events in germinal vesicle breakdown (GVBD), an important milestone of oocyte nuclear maturation, to delineate the developmental capacity of Bubalus bubalis oocytes. In addition, the expression profile of genes responsible for GVBD was assessed in order to understand the molecular context responsible for GVBD. The chronology of GVBD events at different time intervals during in vitro maturation (IVM) suggests that the rate at which oocytes undergo GVBD was strikingly different in the brilliant cresyl blue (BCB)+ and BCB− groups. The expression of AKT and CDC25B genes for BCB+ oocytes was maximum at 8 h of IVM, and CCNB (cyclin B) peaked at around 10 h, which suggested that GVBD was finished after 10 h in BCB+ oocytes, whereas the expression of AKT and CDC25B was found to peak at around 12–14 h of IVM. This difference consequently delays the GVBD event by 2–4 h in BCB− oocytes. Poor abundance of gene transcripts was mainly implicated in delay and lower rate of GVBD in BCB− oocytes which in turn strongly affected the translational ability of oocytes to blastocysts. The findings of this study support the idea that there is a propensity in sub-optimal grade oocytes for delayed GVBD that compromises the developmental ability of low grade buffalo oocytes. The study highlights the very small, but importantly vital and separate, time window of the GVBD event during which the competence levels of buffalo oocytes are altered along with their translational ability to develop into the prospective embryos.
Development and implementation of an advance care planning program in Catalonia, Spain
Authors: Lasmarías Cristina , Aradilla-Herrero Amor , Santaeugènia Sebastià , Blay Carles , Delgado Sara , Ela Sara , Terribas Núria , Gómez-Batiste Xavier 
Published: October 2018

AbstractObjectiveImplementation of an advance care planning (ACP) program for people with advanced chronic conditions is a complex process. The aims of this paper are to describe (1) the development of the ACP program in Catalonia, Spain, for patients with advanced chronic conditions and complex needs and (2) the preliminary results of the implementation of this program in health and social services.MethodThe ACP program was developed and implemented in a four-stage process as follows: (1) design and organization of the project; (2) selection of the professionals to carry out the project; (3) creation of four working groups to develop the conceptual model, guidelines, training program, and perform a qualitative evaluation; and (4) project implementation.ResultThe following deliverables were completed: (1) conceptual framework document; (2) practical guidelines for the application of the ACP; (3) online training course (3,763 healthcare professionals completed the online course, with an overall satisfaction rating of 8.4 on a 10-point scale); and (4) additional training activities (conferences, short courses, and seminars) in between 2015 and 2017.Significance of resultsThis project was led by the Catalan Ministry of Health. The strengths of the project development include the contribution of a wide range of professionals from the entire region, approval by the Catalan Bioethics Committee and the Social Services Ethics Committee, and the ongoing validation by members of the community. A standardized online training course was offered to all primary care professionals and included as a quality indicator for continuing education for those professionals in the period 2016–2020. The main outcome of this project is the establishment of a pragmatic ACP throughout the region and training of the health and social care professionals involved in the care of advanced chronic patients.