bluuebunny/crossref_metadata_2025_split huggingface dataset:
China's Anti‐Corruption Campaign and Financial Reporting Quality
Authors: Hope Ole‐Kristian , Yue Heng , Zhong Qinlin 
Published: August 2019

ABSTRACTWe examine the impact of China's anti‐corruption campaign on firm‐level financial reporting quality (FRQ). As an important component of the anti‐corruption campaign, in October 2013, “Rule 18” was issued to prohibit party and government officials from serving as directors for publicly listed firms. The regulation led to a large number of official directors resigning from their roles as directors involuntarily. As such, Rule 18 has effectively weakened, if not fully discontinued, the political connections of the firms that previously hired officials as directors. Our empirical analyses employ a difference‐in‐differences research design with firm fixed effects and propensity‐score matching to examine the pre‐ and post‐period FRQ around the enactment of Rule 18. We find that, compared to propensity‐score‐matched control firms, FRQ of firms with resigned official directors increases after Rule 18. Further evidence suggests that the impact is stronger when firms are located in regions with more developed financial markets and in regions with higher judiciary efficiency. We also find that the effect is more pronounced when firms are non‐state‐owned, received preferential credits, and face refinancing pressure.
Merchant and marauder—The adventures of a Sabaean clansman
Authors: Multhoff Anne 
Published: August 2019

AbstractTen years ago, a Sabaean inscription on a votive plaque of bronze was made known—immediately attracting the attention of the scholarly world because of its historical implications. This text, which has been given the sigla BL‐Nashq ? and Demirjian 1, respectively, by the editors, speaks—among others—about a commercial journey of its author to the north of the Arabian Peninsula—as far as Gaza, Judah, and even Cyprus. While the key message of this account is quite clear, a controversial discussion has evolved around the date of the “war between Chaldaea and Greece” mentioned in the text, thus yielding inconsistent proposals stretching from the seventh up to the early fourth century BC. In the search for possible synchronisms of the events mentioned in the text, however, clear parallels from Ancient South Arabia have almost been neglected. In a number of mostly Minaic inscriptions, first of all RES 3022, some striking lexical and formulaic isoglosses with the Sabaic text can be made out which can hardly be explained by coincidence. A thorough reconsideration of these texts will demonstrate that the events described in BL‐Nashq ? = Demirjian 1 could have found resonance in other documents from the region—resulting in a consistent chronological framework for all involved texts. In conclusion, we may watch the story of a Sabaean official in his commercial and diplomatic involvement with northern Arabia and the Levant in the shadow of political tensions within the Achaemenid Empire in the late fifth–early fourth century BCE.
Should cigarette pack sizes be capped?
Authors: Blackwell Anna K. M. , Lee Ilse , Scollo Michelle , Wakefield Melanie , Munafò Marcus R. , Marteau Theresa M. 
Published: August 2019

AbstractBackgroundVery few countries regulate maximum cigarette pack size. Larger, non‐standard sizes are increasingly being introduced by the tobacco industry. Larger portion sizes increase food consumption; larger cigarette packs may similarly increase tobacco consumption. Here we consider the evidence for legislation to cap cigarette pack size to reduce tobacco‐related harm.Aims and analysisWe first describe the regulations regarding minimum and maximum pack sizes in the 12 countries that have adopted plain packaging legislation and describe the range of sizes available. We then discuss evidence for two key assumptions that would support capping pack size. First, regarding the causal nature of the relationship between pack size and tobacco consumption, observational evidence suggests that people smoke fewer cigarettes when using smaller packs. Secondly, regarding the causal nature of the relationship between reducing consumption and successful cessation, reductions in number of cigarettes smoked per day are associated with increased cessation attempts and subsequent abstinence. However, more experimental evidence is needed to infer the causal nature of these associations among general populations of smokers.ConclusionCigarette pack size is positively associated with consumption and consumption is negatively associated with cessation. Based on limited evidence of the causal nature of these associations, we hypothesize that government regulations to cap cigarette pack sizes would positively contribute to reducing smoking prevalence.
Late relapse in patients with diffuse large B‐cell lymphoma: impact of rituximab on their incidence and outcome
Authors: Vannata Barbara , Conconi Annarita , Winkler Jonas , Cascione Luciano , Margiotta Casaluci Gloria , Nassi Luca , Moia Riccardo , Pirosa Maria Cristina , Moccia Alden A. , Stathis Anastasios , Rossi Davide , Gaidano Gianluca , Zucca Emanuele 
Published: August 2019

SummaryDiffuse large B‐cell lymphoma (DLBCL) constitutes 25–35% of all non‐Hodgkin lymphomas in Western countries. Approximately two thirds of the patients can be cured with standard immuno‐chemotherapy. Most relapses occur within 1–2 years from diagnosis, however, the occurrence of relapses after 5 years or more has been described. We aimed at defining the incidence and clinical features of late relapses. Data of 1113 DLBCL patients were analysed. Among the 196 patients relapsing after a first complete remission, 36 (18% of relapses and 3% of all DLBCLs) experienced a recurrence more than 5 years from diagnosis. Late relapsing patients, in comparison with those relapsing earlier, showed a more favourable risk profile at presentation: normal lactate dehydrogenase levels (P = 0·002), early Ann Arbor stage (P = 0·006) and low International Prognostic Index (P = 0·003). The risk of late relapse was lowered by the introduction of rituximab as part of the front‐line treatment (P < 0·001). Cause‐specific survival (CSS) from the time of relapse was significantly better for late relapsing patients compared to those relapsing early: 5‐year CSS rates were 53% and 31%, respectively (P = 0·033). A trend toward a better overall survival was also observed, with 5‐year rates after relapse of 47% and 25%, respectively (P = 0·054).
Sequestosome‐1 (p62) expression reveals chaperone‐assisted selective autophagy in immune‐mediated necrotizing myopathies
Authors: Fischer Norina , Preuße Corinna , Radke Josefine , Pehl Debora , Allenbach Yves , Schneider Udo , Feist Eugen , von Casteleyn Vincent , Hahn Katrin , Ruck Tobias , Meuth Sven G. , Goebel Hans‐Hilmar , Graf Rose , Mammen Andrew , Benveniste Olivier , Stenzel Werner 
Published: August 2019

AbstractDiffuse myofiber necrosis in the context of inflammatory myopathy is the hallmark of immune‐mediated necrotizing myopathy (IMNM). We have previously shown that skeletal muscle fibers of IMNM patients may display nonrimmed vacuoles and sarcoplasmic irregularities. The dysfunctional chaperone activity has been linked to the defective assembly of skeletal muscle proteins and their degradation via lysosomes, autophagy and the proteasomal machinery. This study was undertaken to highlight a chaperone‐assisted selective autophagy (CASA) pathway, functionally involved in protein homeostasis, cell stress and the immune response in skeletal muscle of IMNM patients. Skeletal muscle biopsies from 54 IMNM patients were analyzed by immunostaining, as well as by qPCR. Eight biopsies of sIBM patients served as pathological controls, and eight biopsies of nondisease control subjects were included. Alteration of autophagy was detectable in all IMNM biopsy samples highlighted via a diffuse sarcoplasmic staining pattern by p62 and LC3 independent of vacuoles. This pattern was at variance with the coarse focal staining pattern mostly confined to rimmed vacuoles in sIBM. Colocalization of p62 with the chaperone proteins HSP70 and αB‐crystalline points to the specific targeting of misfolded proteins to the CASA machinery. Bcl2‐associated athanogene 3 (BAG3) positivity of these fibers emphasizes the selectivity of autophagy processes and these fibers also express MHC class I sarcolemma. Expression of genes involved in autophagy and endoplasmic reticulum (ER) stress pathways studied here is significantly upregulated in IMNM. We highlight that vacuoles without sarcolemmal features may arise in IMNM muscle biopsies, and they must not be confounded with sIBM‐specific vacuoles. Further, we show the activation of selective autophagy and emphasize the role of chaperones in this context. CASA occurs in IMNM muscle, and specific molecular pathways of autophagy differ from the ones in sIBM, with p62 as a unique identifier of this process.
Putative risk alleles for LATE‐NC with hippocampal sclerosis in population‐representative autopsy cohorts
Authors: Hokkanen Suvi R. K. , Kero Mia , Kaivola Karri , Hunter Sally , Keage Hannah A. D. , Kiviharju Anna , Raunio Anna , Tienari Pentti J. , Paetau Anders , Matthews Fiona E. , Fleming Jane , Graff Caroline , Polvikoski Tuomo M. , Myllykangas Liisa , Brayne Carol ,   EClipSE Collaboration
Published: August 2019

AbstractLimbic‐predominant age‐related TAR‐DNA‐binding protein‐43 (TDP‐43) encephalopathy with hippocampal sclerosis pathology (LATE‐NC + HS) is a neurodegenerative disorder characterized by severe hippocampal CA1 neuron loss and TDP‐43‐pathology, leading to cognitive dysfunction and dementia. Polymorphisms in GRN, TMEM106B and ABCC9 are proposed as LATE‐NC + HS risk factors in brain bank collections. To replicate these results in independent population‐representative cohorts, hippocampal sections from brains donated to three such studies (Cambridge City over 75‐Cohort [CC75C], Cognitive Function and Ageing Study [CFAS], and Vantaa 85+ Study) were stained with hematoxylin–eosin (n = 744) and anti‐pTDP‐43 (n = 713), and evaluated for LATE‐NC + HS and TDP‐43 pathology. Single nucleotide polymorphism genotypes in GRN rs5848, TMEM106B rs1990622 and ABCC9 rs704178 were determined. LATE‐NC + HS (n = 58) was significantly associated with the GRN rs5848 genotype (χ2(2) = 20.61, P < 0.001) and T‐allele (χ2(1) = 21.04, P < 0.001), and TMEM106B rs1990622 genotype (Fisher's exact test, P < 0.001) and A‐allele (χ2(1) = 25.75, P < 0.001). No differences in ABCC9 rs704178 genotype or allele frequency were found between LATE‐NC + HS and non‐LATE‐NC + HS neuropathology cases. Dentate gyrus TDP‐43 pathology associated with GRN and TMEM106B variations, but the association with TMEM106B nullified when LATE‐NC + HS cases were excluded. Our results indicate that GRN and TMEM106B are associated with severe loss of CA1 neurons in the aging brain, while ABCC9 was not confirmed as a genetic risk factor for LATE‐NC + HS. The association between TMEM106B and LATE‐NC + HS may be independent of dentate TDP‐43 pathology.
Elevation of casein kinase 1ε associated with TDP‐43 and tau pathologies in Alzheimer's disease
Authors: Gu Jianlan , Hu Wen , Tan Xuefeng , Qu Shuting , Chu Dandan , Gong Cheng‐Xin , Iqbal Khalid , Liu Fei 
Published: August 2019

AbstractAlzheimer's disease (AD) is characterized by the presence of extracellular amyloid β plaques and intraneuronal neurofibrillary tangles of hyperphosphorylated microtubule‐associated protein tau in the brain. Aggregation of transactive response DNA‐binding protein of 43 kDa (TDP‐43) in the neuronal cytoplasm is another feature of AD. However, how TDP‐43 is associated with AD pathogenesis is unknown. Here, we found that casein kinase 1ε (CK1ε) phosphorylated TDP‐43 at Ser403/404 and Ser409/410. In AD brains, the level of CK1ε was dramatically increased and positively correlated with the phosphorylation of TDP‐43 at Ser403/404 and Ser409/410. Overexpression of CK1ε promoted its cytoplasmic aggregation and suppressed TDP‐43‐promoted tau mRNA instability and tau exon 10 inclusion, leading to an increase of tau and 3R‐tau expressions. Levels of CK1ε and TDP‐43 phosphorylation were positively correlated with the levels of total tau and 3R‐tau in human brains. Furthermore, we observed, in pilot immunohistochemical studies, that the severe tau pathology was accompanied by robust TDP‐43 pathology and a high level of CK1ε. Taken together, our findings suggest that the elevation of CK1ε in AD brain may phosphorylate TDP‐43, promote its cytoplasmic aggregation and suppress its function in tau mRNA processing, leading to acceleration/exacerbation of tau pathology. Thus, the elevation of CK1ε may link TDP‐43 to tau pathogenesis in AD brain.
Bar versus ball attachments for maxillary four‐implant retained overdentures: A randomized controlled trial
Authors: Park Jin‐Hong , Shin Sang‐Wan , Lee Jeong‐Yol 
Published: August 2019

AbstractObjectivesTo compare the clinical treatment outcomes of maxillary four‐implant retained overdentures with either splinted (bar) attachments or non‐splinted (ball) attachments.Material and MethodsForty participants who were dissatisfied with their existing conventional maxillary complete dentures were included in this randomized controlled trial. Six months after implant placement, a definitive prosthesis was inserted. Implant success, condition of peri‐implant tissue, prosthodontic maintenance and complications, and patient satisfaction were assessed. Outcomes were recorded at baseline, prosthesis delivery, and at 3 and 12 months following prosthesis delivery, and a statistical analysis was performed.ResultsThirty‐two of the forty patients completed the 1‐year follow‐up and had their treatment outcomes evaluated. The mean marginal bone loss after 1 year of loading was 0.34 ± 0.88 mm, and there were no significant differences between the two groups. Plaque index, gingival index and bleeding on probing were significantly higher in the bar group (p<.001), and the implant success rate of the bar group was significantly lower than that of the ball group (p=.028). The most frequent prosthodontic maintenance and complication issue was the need to change the bar clip or O‐ring as a result of retention loss. Patient satisfaction did not differ between the two groups except for aesthetics at 3 months.ConclusionsWithin the limitations of this study, the maxillary 4‐implant retained overdenture exhibited predictable results regardless of the attachment systems (ball or bar) in the 1‐year follow‐up period. The bar group was more vulnerable than the ball group with respect to maintaining peri‐implant tissue health.
Rethinking the native range concept
Authors: Pereyra Patricio Javier 
Published: August 2019

AbstractA species is not native outside its native range, but native range is not precisely defined. The invasion literature contains wide discussion of the core concepts such as naturalization, invasiveness, and ecological impact, but the concept of native range has received so little attention that a formal definition does not exist. I considered, among other impediments to a formal definition of native range, the sometimes arbitrariness of the spatial and temporal limits assigned to native range. Broad questions that remain include whether invasion theory can be used to define the native range for species without non‐native ranges.
Allergic contact dermatitis caused by isobornyl acrylate in the Enlite glucose sensor and the Paradigm MiniMed Quick‐set insulin infusion set
Authors: Herman Anne , Baeck Marie , de Montjoye Laurence , Bruze Magnus , Giertz Emil , Goossens An , Mowitz Martin 
Published: August 2019

AbstractBackgroundThe FreeStyle Libre glucose sensor has caused many cases of allergic contact dermatitis, and isobornyl acrylate (IBOA) in this sensor has been identified as one of the culprit allergens.ObjectivesTo report on the presence of IBOA in devices produced by Medtronic, namely, the Enlite sensor and the insulin infusion set Paradigm MiniMed Quick‐set.Patients and MethodsFive patients reacting to the glucose sensor Enlite and/or the insulin infusion set Paradigm MiniMed Quick‐set observed in three clinics (two Belgian and one Swedish) were patch tested with the baseline and other series, as well as with IBOA; four of them also with pieces of adhesive patches from the devices, and two with a thin layer chromatogram of Enlite glucose sensor extracts. Gas chromatography‐mass spectrometry (GC‐MS) analyses were performed.ResultsFour patients reacted to IBOA and one to colophonium, a known allergen in Enlite, and three to the adhesive part of the sensor or the insulin infusion set. IBOA was identified in the sensor by GC‐MS, and its presence was indicated in the infusion set.ConclusionsIBOA is a contact allergen in Enlite glucose sensor, and likely also in the infusion set. Therefore, these devices are not suitable alternatives for patients sensitized to the FreeStyle Libre sensor.
Photorealistic imaging of left atrial appendage occlusion/exclusion
Authors: Vainrib Alan F. , Bamira Daniel , Aizer Anthony , Chinitz Larry A. , Loulmet Didier , Benenstein Ricardo J. , Saric Muhamed 
Published: August 2019

AbstractRecent improvements in 3D TEE post processing rendering techniques referred to as TrueVue (Philips Medical Systems, Andover, MA, USA). It allows for novel photorealistic imaging of cardiac structures including left atrial appendage (LAA) and its closure devices. Here we present TrueVue images of the LAA prior to and after LAA exclusion/occlusion using various percutaneous and surgical techniques. TrueVue may improve delineation of LAA anatomy prior to occlusion as well as visualization of occluder device position within the LAA.
Top 100 most‐cited articles on echocardiography: A bibliometric analysis
Authors: Huang Yongfa , Liu Yifan , Liu Huazhen , Hong Xinyu , Guo Xiaoxiao , Fang Ligang 
Published: August 2019

AbstractEchocardiography has been widely applied since 1970s, and has developed into a reliable approach to assess the heart in both cardiology and interdisciplinary settings. A bibliometric analysis can reveal its development history, major applications, and trending in the future. Two independent researchers conducted proper literature retrieval in Web of Science database and ranked search results by total citation. The abstracts of articles were carefully reviewed and top 100 most‐cited articles were included. Most top‐cited studies on echocardiography were performed in USA (66%) by cardiologists (62%) and published in high‐impact cardiology specialized journals like Circulation (39%). Most top‐cited articles were published in two 5‐year intervals of 1995 ~ 1999 and 2000 ~ 2004 which witnessed the invention and promotion of new echocardiographic techniques including Doppler tissue imaging and speckle tracking imaging. Most commonly used technologies to investigate primary study endpoints were two‐dimensional echocardiography, M‐mode echocardiography, and Doppler flow imaging. Left ventricular structure (25%), function (19%), and valvular heart disease (13%) have remained vital subjects since the birth of echocardiography. Four of top 10 most‐cited articles published after 2009 focused on the effectiveness of novel cardiovascular therapies and another four focused on cardiotoxicity of cancer chemotherapies. The majority of top‐cited studies on echocardiography were performed in USA and published in cardiology specialized journals by cardiologists. The structure and function of left ventricle and valvular heart disease have remained vital subjects since the birth of echocardiography, which will probably be widely applied to evaluate the effect of various treatments on cardiovascular system.
Access to credit and its determinants: A comparison of survey‐based measures
Authors: Hainz Christa , Nabokin Tatjana 
Published: August 2019

AbstractMeasuring access to finance represents an important challenge in empirical studies. Due to data limitations, perception‐based indicators or the usage of finance are often used as approximations of access to finance. However, these approximations disregard firm‐specific differences in the demand for finance. We derive a direct measure of access to credit from firm‐level survey data and explicitly model credit demand. We study the determinants of access to credit and disentangle, in contrast to other measures, their effects on demand for and access to credit. We find that the usage of credit is not a sufficient approximation, while perception‐based indicators are surprisingly precise.
Predator modulation of plant pathogen spread through induced changes in vector development rates
Authors: Keissar Or , Scharf Inon , Sadeh Asaf 
Published: August 2019

1. Predation on vectors of pathogens can indirectly influence infection spread. In addition to the consumptive aspect of predation, non‐consumptive, predator‐induced changes in various vector traits can lead to trait‐mediated indirect effects on pathogen spread, potentially operating in various directions and magnitudes.2. A widespread non‐consumptive effect of predation is the alteration of individual prey development rates. Yet, the implications of this phenomenon for the spread of vector‐borne plant pathogens have not been studied. It is hypothesized that the epidemiological effects of predator‐induced changes in vector development rate depend on the pattern in which the transmission biology of the vector changes along its ontogeny.3. A general epidemiological model was developed that considers the role of predation in the infection dynamics of a plant pathogen, while incorporating vector stage structure to allow for variation in its development rate.4. By contrasting scenarios that represent typical plant disease systems, this study confirms that the magnitude of the effect of altered development rate on infection prevalence depends on the disparity between juvenile and adult vectors in their pathogen transmission potential.5. The model also reveals that the effect of predator‐induced change in development rate can impact pathogen spread counterintuitively. Specifically, slowing down vector development can result in increased pathogen prevalence due to apparent competition between infected and uninfected vector populations.6. More detailed, stage‐specific studies of non‐consumptive predator effects on vectors are likely to advance our understanding of plant disease ecology, and the development of more effective biological control practices in agriculture.