bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serial echocardiographic changes with different body positions and sleeping side preference in heart failure patients
Authors: Bayraktar Muhammed Fatih , Ozeke Ozcan 
Published: April 2018

BackgroundThe sleeping position plays an important role in overall health in both healthy individuals and heart failure (HF) patients, which complain of increasing dyspnea when adopting left lateral decubitus position (LLDP) that improves when turning over to the right lateral decubitus position (RLDP). Several theories have been proposed to explain this preference of HF patients; however, the underlying mechanisms remain unclear.MethodWe evaluated consecutive dilated cardiomyopathy (DCMP) patients with regard to whether they had a sleeping position preference and analyzed early and late left ventricular filling velocities, tissue Doppler recordings, tricuspid annular plane systolic excursion (TAPSE), and left ventricular outflow tract time‐velocity integral (LVOT‐TVI). Baseline echocardiographic parameters were obtained first by LLDP, followed by the supine position (SP) and finally RLDP in each position for 10 minutes to ensure a stabilized hemodynamic milieu.ResultsA total of 26 DCMP patients were included in this study and a 78 echocardiographic examination performed. We detected that many HF patients preferred the right lateral decubitus sleeping position (RLDSP, 54%) and avoided from the left lateral decubitus sleeping position (LLDSP, 40%); the echocardiographic LVOT TVI and TAPSE parameters were statistically higher in RLDP compared to SP and LLDP.ConclusionThe echocardiographic LVOT TVI and TAPSE values as functional parameters of left and right ventricular function change with body position, and these hemodynamic changes may explain why HF patients willingly adopt RLDSP.
Chronological changes in the epidemiological characteristics of upper urinary tract urolithiasis in Japan
Authors: Sakamoto Shinichi , Miyazawa Katsuhito , Yasui Takahiro , Iguchi Taro , Fujita Misuzu , Nishimatsu Hiroaki , Masaki Takuro , Hasegawa Toru , Hibi Hatsuki , Arakawa Takashi , Ando Ryosuke , Kato Yoshinari , Ishito Noritaka , Yamaguchi Satoshi , Takazawa Ryoji , Tsujihata Masao , Matsuda Tadashi , Akakura Koichiro , Hata Akira , Ichikawa Tomohiko 
Published: April 2018

ObjectivesTo assess epidemiological and chronological trends of upper urinary tract stones in Japan in 2015.MethodsPatients with a first episode of upper urinary tract stones in 2015 were enrolled in this nationwide survey. The study included all hospitals approved by the Japanese Board of Urology, therefore covering most of the hospitals where urologists practice in Japan. The annual incidence and composition of urolithiasis were evaluated by age and sex. These results were compared with the previous results of the nationwide surveys from 1965 to 2005 to analyze temporal trends.ResultsThe estimated annual incidence of a first‐episode upper urinary tract stone in 2015 was 137.9 (191.9 in men and 86.9 in women) per 100 000. The estimated age‐standardized first‐episode upper urinary tract stone incidence in 2015 was 107.8 (150.6 in men and 63.3 in women) per 100 000, which did not represent a significant increase since 2005. An equivalent incidence was observed in patients aged >50 years, whereas a reduced incidence was observed in patients aged <50 years in both sexes. The proportion of patients who received percutaneous nephrolithotomy and/or ureteroscopy increased by approximately fivefold in the past 10 years.ConclusionsThe steady increase in the annual incidence of upper urinary tract stones since 1955 leveled off in 2015. The current results show novel trends in the incidence and treatment modalities in the nationwide surveys of urolithiasis in Japan.
Quality of Author Guidelines in Nursing Journals
Authors: Oermann Marilyn H. , Nicoll Leslie H. , Chinn Peggy L. , Conklin Jamie L. , McCarty Midori , Amarasekara Sathya 
Published: April 2018

AbstractPurposeThe aims of this study were to (a) describe the information provided in author guidelines in nursing journals, (b) assess the completeness of this information, and (c) identify the extent and types of reporting guidelines used in nursing journals.DesignContent analysis of author guidelines for 245 nursing journals included in the Directory of Nursing Journals maintained at the International Academy of Nursing Editors website.MethodsUsing Research Electronic Data Capture, data on 19 criteria for completeness were extracted from published author guidelines. Additional details about journal requirements, such as allowed length of manuscripts and format for the abstract, were also recorded. Reliability was established by simultaneous review of 25 journals (10%) by the research assistant and a senior member of the research team.FindingsAuthor guidelines were easily accessible at journal websites or through links to download the information. A majority (73.5%) had completeness scores of 75% or higher; six journals had guidelines that were 100% complete. Half of the journals used the American Psychological Association reference style, and 26.3% used the American Medical Association style. Less than one fourth had stated requirements to use reporting guidelines such as Consolidated Standards of Reporting Trials (CONSORT) and Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA).ConclusionsAuthor guidelines for nursing journals are generally complete and informative. Although specific reporting guidelines such as CONSORT and PRISMA improve the accuracy and completeness of manuscripts on various types of studies, most nursing journals do not indicate use of these for manuscript preparation. Editors who want to improve their author guidelines should use the 19 criteria for completeness as a gauge for updating and revision.Clinical RelevanceNurses rely on the published literature to inform their practice and ensure that it is based on evidence. Guidelines for publishing in the scholarly literature assist clinicians and scholars to ensure that published articles are complete, current, concise, and accurate.
INPP4B overexpression and c‐KIT downregulation in human achalasia
Authors: Bonora E. , Bianco F. , Stanzani A. , Giancola F. , Astolfi A. , Indio V. , Evangelisti C. , Martelli A. M. , Boschetti E. , Lugaresi M. , Ioannou A. , Torresan F. , Stanghellini V. , Clavenzani P. , Seri M. , Moonen A. , Van Beek K. , Wouters M. , Boeckxstaens G. E. , Zaninotto G. , Mattioli S. , De Giorgio R. 
Published: April 2018

AbstractBackgroundAchalasia is a rare motility disorder characterized by myenteric neuron and interstitial cells of Cajal (ICC) abnormalities leading to deranged/absent peristalsis and lack of relaxation of the lower esophageal sphincter. The mechanisms contributing to neuronal and ICC changes in achalasia are only partially understood. Our goal was to identify novel molecular features occurring in patients with primary achalasia.MethodsEsophageal full‐thickness biopsies from 42 (22 females; age range: 16‐82 years) clinically, radiologically, and manometrically characterized patients with primary achalasia were examined and compared to those obtained from 10 subjects (controls) undergoing surgery for uncomplicated esophageal cancer (or upper stomach disorders). Tissue RNA extracted from biopsies of cases and controls was used for library preparation and sequencing. Data analysis was performed with the “edgeR” option of R‐Bioconductor. Data were validated by real‐time RT‐PCR, western blotting and immunohistochemistry.Key ResultsQuantitative transcriptome evaluation and cluster analysis revealed 111 differentially expressed genes, with a P ≤ 10−3. Nine genes with a P ≤ 10−4 were further validated. CYR61, CTGF, c‐KIT, DUSP5, EGR1 were downregulated, whereas AKAP6 and INPP4B were upregulated in patients vs controls. Compared to controls, immunohistochemical analysis revealed a clear increase in INPP4B, whereas c‐KIT immunolabeling resulted downregulated. As INPP4B regulates Akt pathway, we used western blot to show that phospho‐Akt was significantly reduced in achalasia patients vs controls.Conclusions & InferencesThe identification of altered gene expression, including INPP4B, a regulator of the Akt pathway, highlights novel signaling pathways involved in the neuronal and ICC changes underlying primary achalasia.
Gingival leukemic infiltration as the first manifestation of acute myeloid leukemia
Authors: Fernandes Karin Sá , Gallottini Marina , Castro Talita , Amato Mauricio Flamínio , Lago Juvani Saturno , Braz‐Silva Paulo Henrique 
Published: April 2018

ABSTRACTLeukemic infiltration of the gingival tissue associated or not with gingival enlargement may be the first manifestation of acute leukemia, despite being rarely reported in the literature. A 10‐year‐old female patient presented with a 1‐month history of an asymptomatic, firm, and pinkish‐red generalized gingival overgrowth. There was no bone resorption. Incisional biopsy of the gingival tissue was performed, with histopathological examination revealing a diffuse and hypercellular infiltration of monocytoid cells. The patient was referred to a hematologist and underwent a bone marrow biopsy, which led to a conclusive diagnosis of acute myeloid leukemia. The patient was treated with chemotherapy and we observed regression of gingival enlargement after 4 weeks from the initial therapy.
Evaluation of a new chest physiotherapy technique in dogs with airway fluid accumulation hospitalized in an intensive care unit
Authors: Pouzot‐Nevoret Céline , Goy‐Thollot Isabelle , Billet Didier , Barthélemy Anthony , Blesch Maïlys , Pin Aurélie , Hopper Kate 
Published: April 2018

AbstractObjectiveTo evaluate the feasibility, benefits, and adverse effects of prolonged slow expiration (PSE) and assisted cough (AC) as chest physiotherapy (CP) techniques in dogs with airway fluid accumulation.DesignProspective interventional study.SettingsUniversity teaching hospital.AnimalsIntervention group of 30 client‐owned dogs and retrospective control group of 71 client‐owned dogs.InterventionsPSE was performed on dogs with evidence of airway fluid accumulation, identified based on physical examination and thoracic radiographs. AC was performed if spontaneous cough or swallowing were not evident. The PSE treatment was performed every 6 hours until normalization of respiratory status or hospital discharge. Animals were monitored for respiratory distress, discomfort, and SpO2 during the procedure. A retrospective control group was identified by computer search.Measurements and Main ResultsOne hundred thirty‐three sessions of CP were performed on 30 dogs. Discomfort frequency during physiotherapy was low (9%). The most commonly used position for CP was in lateral recumbency (95%) and this was well tolerated in most cases. There was no significant difference in the median SpO2 before and after CP sessions (P = 0.24). Sixty percent of sessions had a spontaneous cough or swallowing evident, 21% had successful AC performed, and no cough or swallowing occurred in the remaining (19%) sessions despite attempts of AC being made. The length of hospitalization was significantly longer in the intervention group (6 days vs 4) (P = 0.02). There was no difference in survival between the intervention (76.7%) and the control (57.7%) group (P = 0.055).ConclusionsPSE associated with AC are easily adaptable, well‐tolerated techniques in dogs. The benefit of CP in dogs with airway fluid accumulation remains to be determined and it is hoped that future randomized controlled prospective studies may help answer this line of inquiry.
Arginase-1 Expression in Myeloid Cells Regulates Staphylococcus aureus Planktonic but Not Biofilm Infection
Authors: Yamada Kelsey J. , Heim Cortney E. , Aldrich Amy L. , Gries Casey M. , Staudacher Anna G. , Kielian Tammy 
Published: April 2018

ABSTRACTStaphylococcus aureusis a leading cause of device-associated biofilm infections, which represent a serious health care concern based on their chronicity and antibiotic resistance. We previously reported thatS. aureusbiofilms preferentially recruit myeloid-derived suppressor cells (MDSCs), which promote monocyte and macrophage anti-inflammatory properties. This is associated with increased myeloid arginase-1 (Arg-1) expression, which has been linked to anti-inflammatory and profibrotic activities that are observed duringS. aureusbiofilm infections. To determine whether MDSCs and macrophages utilize Arg-1 to promote biofilm infection, Arg-1 was deleted in myeloid cells by use ofTie-2Cremice. Despite Arg-1 expression in biofilm-associated myeloid cells, bacterial burdens and leukocyte infiltrates were similar between wild-type (WT) andArg-1fl/fl;Tie-2Creconditional knockout (KO) mice from days 3 to 14 postinfection in both orthopedic implant and catheter-associated biofilm models. However, inducible nitric oxide synthase (iNOS) expression was dramatically elevated in biofilm-associated MDSCs fromArg-1fl/fl;Tie-2Creanimals, suggesting a potential Arg-1-independent compensatory mechanism for MDSC-mediated immunomodulation. Treatment ofArg-1fl/fl;Tie-2Cremice with the iNOS inhibitor N6-(1-iminoethyl)-l-lysine (l-NIL) had no effect on biofilm burdens or immune infiltrates, whereas treatment of WT mice with the Arg-1/ornithine decarboxylase inhibitor difluoromethylornithine (DFMO) increased bacterial titers, but only in the surrounding soft tissues, which possess attributes of a planktonic environment. A role for myeloid-derived Arg-1 in regulating planktonic infection was confirmed using a subcutaneous abscess model, in whichS. aureusburdens were significantly increased inArg-1fl/fl;Tie-2Cremice compared to those in WT mice. Collectively, these results indicate that the effects of myeloid Arg-1 are context dependent and are manifest during planktonic but not biofilm infection.
Evaluation of the Vitek MS v3.0 Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry System for Identification of Mycobacterium and Nocardia Species
Authors: Body Barbara A. , Beard Melodie A. , Slechta E. Susan , Hanson Kimberly E. , Barker Adam P. , Babady N. Esther , McMillen Tracy , Tang Yi-Wei , Brown-Elliott Barbara A. , Iakhiaeva Elena , Vasireddy Ravikiran , Vasireddy Sruthi , Smith Terry , Wallace Richard J. , Turner S. , Curtis L. , Butler-Wu Susan , Rychert Jenna 
Published: April 2018

ABSTRACT

This multicenter study was designed to assess the accuracy and reproducibility of the Vitek MS v3.0 matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) mass spectrometry system for identification of
Mycobacterium
and
Nocardia
species compared to DNA sequencing. A total of 963 clinical isolates representing 51 taxa were evaluated. In all, 663 isolates were correctly identified to the species level (69%), with another 231 (24%) correctly identified to the complex or group level. Fifty-five isolates (6%) could not be identified despite repeat testing. All of the tuberculous mycobacteria (45/45; 100%) and most of the nontuberculous mycobacteria (569/606; 94%) were correctly identified at least to the group or complex level. However, not all species or subspecies within the
M. tuberculosis
,
M. abscessus
, and
M. avium
complexes and within the
M. fortuitum
and
M. mucogenicum
groups could be differentiated. Among the 312
Nocardia
isolates tested, 236 (76%) were correctly identified to the species level, with an additional 44 (14%) correctly identified to the complex level. Species within the
N. nova
and
N. transvalensis
complexes could not always be differentiated. Eleven percent of the isolates (103/963) underwent repeat testing in order to get a final result. Identification of a representative set of
Mycobacterium
and
Nocardia
species was highly reproducible, with 297 of 300 (99%) replicates correctly identified using multiple kit lots, instruments, analysts, and sites. These findings demonstrate that the system is robust and has utility for the routine identification of mycobacteria and
Nocardia
in clinical practice.
Neutralizing Antibody Responses following Long-Term Vaccination with HIV-1 Env gp140 in Guinea Pigs
Authors: Bricault Christine A. , Kovacs James M. , Badamchi-Zadeh Alexander , McKee Krisha , Shields Jennifer L. , Gunn Bronwyn M. , Neubauer George H. , Ghantous Fadi , Jennings Julia , Gillis Lindsey , Perry James , Nkolola Joseph P. , Alter Galit , Chen Bing , Stephenson Kathryn E. , Doria-Rose Nicole , Mascola John R. , Seaman Michael S. , Barouch Dan H. 
Published: April 2018

ABSTRACT
A vaccination regimen capable of eliciting potent and broadly neutralizing antibodies (bNAbs) remains an unachieved goal of the HIV-1 vaccine field. Here, we report the immunogenicity of longitudinal prime/boost vaccination regimens with a panel of HIV-1 envelope (Env) gp140 protein immunogens over a period of 200 weeks in guinea pigs. We assessed vaccine regimens that included a monovalent clade C gp140 (C97ZA012 [C97]), a tetravalent regimen consisting of four clade C gp140s (C97ZA012, 459C, 405C, and 939C [4C]), and a tetravalent regimen consisting of clade A, B, C, and mosaic gp140s (92UG037, PVO.4, C97ZA012, and Mosaic 3.1, respectively [ABCM]). We found that the 4C and ABCM prime/boost regimens were capable of eliciting greater magnitude and breadth of binding antibody responses targeting variable loop 2 (V2) over time than the monovalent C97-only regimen. The longitudinal boosting regimen conducted over more than 2 years increased the magnitude of certain tier 1 NAb responses but did not increase the magnitude or breadth of heterologous tier 2 NAb responses. These data suggest that additional immunogen design strategies are needed to induce broad, high-titer tier 2 NAb responses.

IMPORTANCE
The elicitation of potent, broadly neutralizing antibodies (bNAbs) remains an elusive goal for the HIV-1 vaccine field. In this study, we explored the use of a long-term vaccination regimen with different immunogens to determine if we could elicit bNAbs in guinea pigs. We found that longitudinal boosting over more than 2 years increased tier 1 NAb responses but did not increase the magnitude and breadth of tier 2 NAb responses. These data suggest that additional immunogen designs and vaccination strategies will be necessary to induce broad tier 2 NAb responses.
A bandpass sigma-delta modulator with the function of adjustable center-frequency
Authors: Di Xin Peng , Chen Wei Ping , Liu Xiao Wei , Fan Ling Yun 
Published: April 2018

A bandpass sigma-delta modulator with the function of adjustable center-frequency is present in this paper. A method used to convert 2-order low-pass modulator to 4-order bandpass modulator is proposed to realize the design. Center-frequency that can be set to 1/6, 1/4 and 1/3 of sampling frequency is controlled according to the digital logic voltage. The bandwidth of pass-band is 200 Hz. Test results show that the average SNR is about 80 dB at different center-frequency when the sampling frequency is 64 kHz. The input signal can reach to −3 dBFs. The complexity to design a variable center-frequency bandpass modulator is greatly reduced.
Garnet–monazite rare earth element relationships in sub-solidus metapelites: a case study from Bhutan
Authors: Warren Clare J. , Greenwood Lucy V. , Argles Tom W. , Roberts Nick M. W. , Parrish Randall R. , Harris Nigel B. W. 
Published: April 2018

Abstract
A key aim of modern metamorphic geochronology is to constrain precise and accurate rates and timescales of tectonic processes. One promising approach in amphibolite and granulite-facies rocks links the geochronological information recorded in zoned accessory phases such as monazite to the pressure–temperature information recorded in zoned major rock-forming minerals such as garnet. Both phases incorporate rare earth elements (REE) as they crystallize and their equilibrium partitioning behaviour potentially provides a useful way of linking time to temperature. We report REE data from sub-solidus amphibolite-facies metapelites from Bhutan, where overlapping ages, inclusion relationships and Gd/Lu ratios suggest that garnet and monazite co-crystallized. The garnet–monazite REE relationships in these samples show a steeper pattern across the heavy (H)REE than previously reported. The difference between our dataset and the previously reported data may be due to a temperature-dependence on the partition coefficients, disequilibrium in either dataset, differences in monazite chemistry or the presence or absence of a third phase that competed for the available REE during growth. We urge caution against using empirically-derived partition coefficients from natural samples as evidence for, or against, equilibrium of REE-bearing phases until monazite–garnet partitioning behaviour is better constrained.
Beneficial impacts of regular exercise on platelet function in sedentary older adults: evidence from a randomized 6-mo walking trial
Authors: Haynes Andrew , Linden Matthew D. , Robey Elisa , Naylor Louise H. , Ainslie Philip N. , Cox Kay L. , Lautenschlager Nicola T. , Green Daniel J. 
Published: April 2018

Platelet activation, including the formation of monocyte platelet aggregates (MPAs), contributes to atherosclerosis, thrombus formation, and acute coronary syndromes. Regular participation in exercise can lower cardiovascular risk, but little is known regarding the impact of exercise training on platelet function. We investigated the effect of 6 mo of walking exercise on platelet function in sedentary older adults without significant cardiovascular disease. Twenty-seven participants were randomly allocated to 6 mo of either: no-exercise ( n = 13) or 3 × 50 min/wk of supervised center-based walking ( n = 14). Circulating and agonist-induced MPAs were assessed using flow cytometry before [ month 0 (0M)] and after [ month 6 (6M)] the intervention. Circulating MPAs increased from 0M (3.7 ± 1.0%) to 6M (4.7 ± 1.6%) in the no-exercise group ( P = 0.009), whereas a nonsignificant decrease was observed in the walking group (0M 4.3 ± 1.7 vs. 6M 3.7 ± 1.2 %, P = 0.052). The change in MPAs between groups was significant ( P = 0.001). There were no differences between groups in platelet responses to agonists across the interventions (all P > 0.05). Collectively, these data suggest that the absence of regular exercise may increase MPAs, which are cellular mediators involved in atherosclerosis, while regular walking inhibits such increases. The thrombotic function of platelets appears to be relatively unaltered by exercise training. This study provides novel data related to the cardioprotective effects associated with participation in exercise.NEW & NOTEWORTHY Monocyte-platelet aggregates contribute to atherosclerosis and exercise can lower cardiovascular risk. This is the first study to discover that a lack of regular physical activity is associated with increased monocyte-platelet aggregates over a 6-mo intervention period. In contrast, walking exercise inhibits increased monocyte-platelet aggregates in the circulation. This study highlights a novel pathway by which regular participation in exercise exerts its cardioprotective effects.