bluuebunny/crossref_metadata_2025_split huggingface dataset:
FAKTOR YANG BERHUBUNGAN DENGAN PERILAKU IBU RUMAH TANGGA MELAKUKAN PEMERIKSAAN PAYUDARA SENDIRI (SADARI)
Authors: Arafah Alvita Brilliana R. , Notobroto Hari Basuki 
Published: November 2018

Breast cancer is cancer with the number of new cases and deaths highest in Indonesia. According to the Data Center and Information Ministry of a health Indonesia in the year 2013, the number of new cases of breast cancer of 819 and the number of deaths amounted to 217. In general, breast cancer known after stepping on an advanced stage. So the methods of early detection of breast cancer are focused on the detection of early stage tumors that are usually small with self-breast examination (SADARI). The purpose of this research is to predict the factors related to the behavior of self-breast examination (SADARI) the housewives aged 40–50 years. This research is an observational study with cross sectional approach. Sample research totaling 100 people housewife in Kelurahan Sidotopo Wetan Kenjeran Subdistrict Surabaya. The measurement was done by providing a questionnaire to obtain information about the research variables. Variable independent research is k nowledge, attitudes, information accessibility, support health providers and descent with breast cancer. The results of this research showed the variables that are associated with the SADARI behavior of the housewifes is attitude (p = 0.000), accessibility of information (p = 0.000), and health care providers support (p = 0.010). The majority of housewives in Kelurahan Sidotopo Wetan Kenjeran Sub-district Surabaya showed a good attitude and support toward SADARI. In the area surrounding the residence h ousewife get access information easily. There are no support for doing SADARI from health care providers.
HUBUNGAN PENGETAHUAN, SIKAP, DUKUNGAN SUAMI, KONTROL PERILAKU, DAN NIAT IBU DENGAN PERILAKU KADARZI IBU BALITA GIZI KURANG
Authors: Mustafyani Aulidina Dwi , Mahmudiono Trias 
Published: November 2018

Lack of knowledge and attitude might lead to a state of poor behavior in society. Results of nutritional awareness family (KADARZI) survey in 2015 showed 24.09% families and increased to 24.15% in 2016 of families who not aware of nutrition. The aim of the study was to analyze the relationship between knowledge and intention with mother of children under five malnutrition. This was a cross sectional study with 58 samples selected by simple random sampling. Subject in this study was the mother of malnourished children under five. The data were collected through interview using questionnaires, and analyzed using pearson correlation. Of the five indicators, families who weighing weight every months (74.14%), consume a variety of foods (55.1%), iodized salt (100.0%), exclusive breastfeeding (51.72%), and nutritional supplements (100.0%). Most families were having medium level knowledge (53.4%) and poor knowledge (46.6%). There were association between family income (p = 0.040), knowledge (p = 0.033) and intention (p = 0.048) to the behavior of mother towards KADARZI. While attitude, subjective norm, and perceived behavioral control did not have relationship to the behavior of mother toward KADARZI. Knowledge and intention was related to enactment of KADARZI.
APLIKASI PERAMALAN JUMLAH KELAHIRAN DENGAN METODE JARINGAN SYARAF TIRUAN
Authors: Nurdela Safira Amudya 
Published: November 2018

The forecast is a statistic analysis to predict what it will happen in the future using the data and information from the past. This research aimed to apply Artificial Neural Network method for estimate the f ertility rate in Surabaya. The study was descriptive which using secondary data providing from Dinas Kesehatan Kota Surabaya. The study used time series data by recapitulation of fertility rate monthly from 2012-2016. The data analysis used R Program. The result showed the best estimator model for Artificial Neural Network method was 1-3-1 architecture with preprocessing normalized. RMS value of Artificial Neural Network method was 338.1551. The conclusion of this research was the Artificial Neural Network method for estimate the f ertility rate in Surabaya could be used for planning birth control program especially Badan Kependudukan dan Keluarga Berencana Nasional.
Multicomponent Obesity Prevention Intervention in Low-Income Preschoolers: Primary and Subgroup Analyses of the NET-Works Randomized Clinical Trial, 2012–2017
Authors: French Simone A. , Sherwood Nancy E. , Veblen-Mortenson Sara , Crain A. Lauren , JaKa Meghan M. , Mitchell Nathan R. , Hotop Anne Marie , Berge Jerica M. , Kunin Batson Alicia S. , Truesdale Kim , Stevens June , Pratt Charlotte , Esposito Layla 
Published: November 2018

Objectives. To evaluate a multicomponent obesity prevention intervention among diverse, low-income preschoolers. Methods. Parent–child dyads (n = 534) were randomized to the Now Everybody Together for Amazing and Healthful Kids (NET-Works) intervention or usual care in Minneapolis, MN (2012–2017). The intervention consisted of home visits, parenting classes, and telephone check-ins. The primary outcomes were adjusted 24- and 36-month body mass index (BMI). Results. Compared with usual care, the NET-Works intervention showed no significant difference in BMI change at 24 (–0.12 kg/m2; 95% confidence interval [CI] = −0.44, 0.19) or 36 months (–0.19 kg/m2; 95% CI = −0.64, 0.26). Energy intake was significantly lower in the NET-Works group at 24 (–90 kcal/day; 95% CI = −164, −16) and 36 months (–101 kcal/day; 95% CI = −164, −37). Television viewing was significantly lower in the NET-Works group at 24 (rate ratio = 0.84; 95% CI = 0.75, 0.93) and 36 months (rate ratio = 0.88; 95% CI = 0.78, 0.99). Children with baseline overweight or obesity had lower BMI in the NET-Works group than those in usual care at 36 months (–0.71 kg/m2; 95% CI = −1.30, −0.12). Hispanic children had lower BMI in the NET-Works group than those in usual care at 36 months (–0.59 kg/m2; 95% CI = −1.14, −0.04). Conclusions. In secondary analyses, NET-Works significantly reduced BMI over 3 years among Hispanic children and children with baseline overweight or obesity. Trial Registration: ClinicalTrials.gov Identifier: NCT01606891.
Strategies for Weight Reduction Prior to Total Joint Arthroplasty
Authors: Chen Michael J. , Bhowmick Subhrojyoti , Beseler Lucille , Schneider Kristin L. , Kahan Scott I. , Morton John M. , Goodman Stuart B. , Amanatullah Derek F. 
Published: November 2018

* The number of total joint arthroplasty (TJA) procedures done in patients with obesity is increasing in the United States.* Compared with patients without obesity who undergo TJA, patients with obesity are at increased risk for numerous complications including periprosthetic joint infection and revision TJA.* Weight reduction prior to TJA in patients with obesity may mitigate these severe complications and the associated costs.* A multidisciplinary approach is most effective in order to achieve durable long-term weight loss.* Numerous therapies including behavioral, pharmaceutical, and surgical options exist but must be tailored to the individual patient.
Late Dislocation Following Total Hip Arthroplasty
Authors: Heckmann Nathanael , McKnight Braden , Stefl Michael , Trasolini Nicholas A. , Ike Hiroyuki , Dorr Lawrence D. 
Published: November 2018

Background:
Late dislocations after total hip arthroplasty (THA) are challenging for the hip surgeon because the cause is often not evident and recurrence is common. Recently, decreased spinopelvic motion has been implicated as a cause of dislocation. The purpose of this study was to assess the mechanical causes of late dislocation, including the influence of spinopelvic motion.

Methods:
Twenty consecutive patients were studied to identify the cause of their late dislocation. Cup inclination and anteversion were measured on standard pelvic radiographs. Lateral standing and sitting spine-pelvis-hip radiographs were used to measure pelvic motion, femoral mobility, and sagittal cup position by assessing sacral slope, pelvic-femoral angle, and cup ante-inclination. Spinopelvic motion was defined as the difference between the standing and sitting sacral slopes (Δsacral slope). A new measurement, the combined sagittal index, which measures the sagittal acetabular and femoral positions, was used to assess the functional motion of the hip joint and risk of impingement.

Results:
There were 9 anterior dislocations (45%) and 11 posterior dislocations (55%) at a mean of 8.3 years after a primary THA. Eight of the 9 patients with an anterior dislocation had spinopelvic abnormalities such as fixed posterior pelvic tilt when standing, increased standing femoral extension, and an increased standing combined sagittal index. Ten of the 11 patients with a posterior dislocation had abnormal spinopelvic measurements such as decreased spinopelvic motion (average Δsacral slope [and standard error] = 9.0° ± 2.4°), increased femoral flexion, and a decreased sitting combined sagittal index. For every 1° decrease in spinopelvic motion, there was an associated 0.9° increase in femoral motion and, in some patients, this resulted in osseous impingement and dislocation.

Conclusions:
Patients with a late dislocation have abnormal spinopelvic motion that precipitates the dislocation, especially when combined with cup malposition or soft-tissue abnormalities. Spinopelvic stiffness is associated with increased age and increased femoral motion, which may lead to impingement and dislocation. Lateral spine-pelvis-hip radiographs may predict the risk and direction of dislocation.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Effect of Physical Parameters on Outcomes of Total Knee Arthroplasty
Authors: Christensen Tyson C. , Wagner Eric R. , Harmsen William S. , Schleck Cathy D. , Berry Daniel J. 
Published: November 2018

Background:
Increasing body mass index (BMI) has been shown to correlate with increased rates of complications after total knee arthroplasty. To our knowledge, body surface area, body mass, and height have not been investigated in this manner. BMI and body surface area are affected differently by changes in height, and they are affected similarly by changes in weight. The purpose of this study was to quantify revision for any reason, mechanical failure, aseptic loosening, polyethylene wear, reoperation, and any infection after total knee arthroplasty using BMI, body surface area, body mass, and height as continuous variables.

Methods:
Prospectively collected data from a single institution’s total joint registry were used to analyze 22,243 consecutive knees, in 16,106 patients, treated with a primary total knee arthroplasty from 1985 to 2012. The Kaplan-Meier survival method was used to evaluate revision and other common complications, with outcomes assessed using Cox regression analysis. Smoothing spline parameterization was used on physical parameters in these models.

Results:
Increasing BMI, body surface area, body mass, and height were associated with an increased risk of any revision surgical procedure, mechanical failure, and aseptic loosening after total knee arthroplasty. The risk of a revision surgical procedure was directly associated with each 1 standard deviation increase in BMI (hazard ratio [HR], 1.19; p < 0.01), body surface area (HR, 1.37; p < 0.01), body mass (HR, 1.30; p < 0.01), and height (HR, 1.22; p < 0.01). This association was especially demonstrated with revision for mechanical failure (BMI: HR, 1.15; p < 0.01; body surface area: HR, 1.35; p < 0.01; body mass: HR, 1.27; p < 0.01; and height: HR, 1.23; p < 0.01). The risk of failure in the subgroups of mechanical failure including a revision surgical procedure for aseptic loosening or polyethylene wear was also associated with increasing body surface area, body mass, and height. Increasing BMI (HR, 1.22; p < 0.01), body surface area (HR, 2.56; p < 0.01), and body mass (HR, 2.54; p < 0.01) were also associated with increased risk of any infection.

Conclusions:
Increasing BMI, body surface area, body mass, and height were strongly associated with the rates of revision, aseptic loosening, and other common complications following total knee arthroplasty. Body surface area and body mass appear to correlate more strongly with mechanical failure outcomes than BMI or height.

Level of Evidence:
Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Trends in the Orthopaedic Surgery Subspecialty Fellowship Match
Authors: Ruddell Jack H. , Eltorai Adam E.M. , DePasse J. Mason , Kuris Eren O. , Gil Joseph A. , Cho Daniel K. , Paxton E. Scott , Green Andrew , Daniels Alan H. 
Published: November 2018

Background:
Orthopaedic surgery has become increasingly specialized, and most trainees currently complete subspecialty fellowship training. The purposes of this investigation were to evaluate recent trends in U.S. orthopaedic fellowship matches and to provide relevant analyses for future orthopaedic fellowship applicants and fellowship program directors.

Methods:
This study analyzed data from orthopaedic fellowship match programs from 2010 to 2017. For each fellowship, the following variables were analyzed: numbers of positions offered, participating programs, applicant registrations, rank lists submitted by applicants (i.e., completed applications), applicants matched, and filled positions. Applicant-matching success rate and percentage of total fellowship positions filled for each subspecialty were calculated, and trends were evaluated for significance and difference between subspecialties utilizing ordinary least-square regressions, with p < 0.05 indicating significance.

Results:
From 2010 to 2017, the number of fellowship positions that were offered increased in all subspecialties (p < 0.05) except for spine (p = 0.44) and trauma (p = 0.92). Participating fellowship programs increased in all subspecialties (p < 0.05) except spine (p = 0.38) and sports medicine; the latter experienced the only significant decrease (p < 0.05). The largest significant increases (p < 0.05) in both applicant registrations (33.5%) and rank lists submitted by applicants (45.3%) were in adult reconstruction. The subspecialty with the highest applicant-matching success rate during the study period of 2010 to 2017 was sports (mean, 93.5%). Spine and trauma had the lowest applicant-matching success rates in 2016 to 2017. The percentage of positions filled across all subspecialties increased from 2011 to 2017 (p < 0.05); hand had the highest mean (96.6% filled), and adult reconstruction had the largest significant increase from 82.0% in 2010 to 95.5% in 2017 (p < 0.05).

Conclusions:
This investigation provides data with regard to current trends in the orthopaedic fellowship match. Specifically, adult reconstruction fellowship training has recently gained popularity at a more rapid rate than the other subspecialty fellowship pathways, although hand surgery consistently maintains a very high rate of positions filled. Our results for orthopaedic subspecialty fellowship match trends may assist fellowship directors with program planning and career advising and may also assist current residents with fellowship application expectations and career planning.
The Landscape of Protein Tyrosine Phosphatase (Shp2) and Cancer
Authors: Rehman Ashfaq Ur , Rahman Mueed Ur , Khan Muhammad T. , Saud Shah , Liu Hao , Song Dong , Sultana Pinky , Wadood Abdul , Chen Hai-Feng 
Published: November 2018

Role of Shp2: The dysregulation of cell signaling cascades associated with the cell differentiation and
growth, due to the deletion, insertion or point mutation in specific amino acids which alters the intrinsic conformation
of the protein, can ultimately lead to a fatal cancer disease. The protein tyrosine phosphatase has been
recognized as a key regulator of extracellular stimuli such as cytokine receptor and receptor tyrosine kinase signaling.
In the last era, the PTPN11 gene (encode a Shp2 protein) and its association with acute myeloid, juvenile
myelomonocytic, and B-cell acute lymphoblastic leukemia, Noonan syndrome, and myelodysplastic have been
recognized as the cause of such deadly disease due to the occurrence of germline mutations in the interface of
PTP and SH2 domain.

Conclusion:
The current study was designed to focus on the allosteric regulation (autoinhibition) of the of Shp2
protein. Subsequently, it will cover the last 10-year recap of Shp2 protein, their role in cancer, and regulation in
numerous ways (allosteric regulation).
Prostate Cancer Gene Regulatory Network Inferred from RNA-Seq Data
Authors: Moore Daniel , de Matos Simoes Ricardo , Dehmer Matthias , Emmert-Streib Frank 
Published: November 2018

Background:
Cancer is a complex disease with a lucid etiology and in understanding the
causation, we need to appreciate this complexity.

Objective:
Here we are aiming to gain insights into the genetic associations of prostate cancer through
a network-based systems approach using the BC3Net algorithm.

Methods:
Specifically, we infer a prostate cancer Gene Regulatory Network (GRN) from a large-scale
gene expression data set of 333 patient RNA-seq profiles obtained from The Cancer Genome Atlas
(TCGA) database.

Results:
We analyze the functional components of the inferred network by extracting subnetworks
based on biological process information and interpret the role of known cancer genes within each process.
Furthermore, we investigate the local landscape of prostate cancer genes and discuss pathological
associations that may be relevant in the development of new targeted cancer therapies.

Conclusion:
Our network-based analysis provides a practical systems biology approach to reveal the
collective gene-interactions of prostate cancer. This allows a close interpretation of biological activity
in terms of the hallmarks of cancer.
Design, Synthesis and Pharmacological Evalution of 1,3,4-Oxadiazole Derivatives as Collapsin Response Mediator Protein 1 (CRMP 1) Inhibitors
Authors: Panchal Ishan I. , Rajput Roshani , Patel Ashish D. 
Published: November 2018

Objective:
The series of 2-(4-Phenylamino)-N-(5-((4-nitrophenoxy)methyl) -1,3,4-oxadiazol-
2-yl)aceta-mide (5a-5e) and substituted N-(5-(Phenoxymethyl)-1,3,4-oxadiazol-2-yl)-2-
(phenylamino)acetamide (5f-5i) was designed, synthesized and investigated for Collapsin Response
Mediator Protein 1 (CRMP 1) inhibitors as small lung cancer.

Design:
Design of compounds was determined by literature review and molecular docking studies
in iGEMDOCK 2.0.

Materials and Methods:
Novel 1, 3, 4 Oxadiazole derivatives were synthesized and characterized
by melting point, TLC, IR Spectroscopy, Mass spectroscopy and 1H NMR. In vitro biological
evaluation was performed on NCI-H2066 cell line for different concentrations 10-1000μM by telomeric
repeat amplification protocol assay. The assay of telomerase in cellular extracts was modified
from the PCR-based Telomeric-Repeat Amplification Protocol (TRAP), using the oligonucleotides
TS and CX.

Results:
Novel substituted 2-(4-Phenylamino)-N-(5-((4-nitrophenoxy)methyl)-1,3,4-oxadiazol-2-
yl) acetamide (5a-5e) and substituted N-(5-(Phenoxymethyl)-1,3,4-oxadiazol-2-yl)-2-(phenylamino)
acetamide (5f-5i) were synthesized, and characterized using spectral and analytical data.
All compounds have shown considerable % inhibition of Cell Growth with respect to Bevacizumab,
but compound 5a and 5f were equipotent with respect to activity as compared to standard
Bevacizumab.

Conclusion:
Amongst the hybrids, p-nitro substituted derivative (5a) and p-chloro substituted (5f)
showed the highest activity against human lung cancer cell line NCI-H2066 by TRAP assay.
Tertiary Enamides: Versatile and Available Substrates in Synthetic Chemistry
Authors: Cai Xiaohua , Yang Mengzhi , Guo Hui 
Published: November 2018

Background:
Enamines and their variant enamides as powerful and versatile synthons have attracted
great attention in synthetic chemistry. Enamides display unique stability and reduce enaminic reactivity in view
of the electron-withdrawing effect of N-acyl group. A great deal of satisfactory achievements in the synthesis
and application of enamides has been made in recent years. Especially, tertiary enamides without N-H bond
regarded as low reactivity of compounds in the past can act as excellent nucleophiles to react with electrophiles
for the construction of various nitrous molecules.
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Objective: This review focuses on recent advances on tertiary enamides in the synthetic strategies and applications
including addition, coupling reaction, functionalization and electro- or photo-chemical reaction.

Conclusion:
Tertiary enamides as electron-deficient nucleophiles display a satisfactory balance between stability
and reactivity to offer multiple opportunities for the construction of various functionalized nitrogencontaining
compounds. Further exploration of the reactive mechanisms involved tertiary enamides and the development
of novel and efficient transformations to generate ever more complex building blocks starting from
tertiary enamides are particularly worth pursuing.
Synthesis of Phenyl- and Pyridyl-substituted Benzyloxybenzaldehydes by Suzuki-Miyaura Coupling Reactions
Authors: Bölcskei Hedvig , Német-Hanzelik Andrea , Dubrovay Zsófia , Háda Viktor , Keglevich György 
Published: November 2018

Background:
Aryl-methoxybenzaldehydes substituted in various positions may serve as
valuable starting materials for the synthesis of biologically active compounds.

Methods:
Biaryl-methoxybenzaldehydes and pyridyl-aryl-methoxybenzaldehydes were synthesized
by the Suzuki-Miyaura cross-coupling reactions as intermediates of potential drug substances.
Three different catalytic approaches were compared. The classical Suzuki method utilising
tetrakis(triphenylphosphine)palladium and sodium ethoxide, the protocol applying palladium acetate
and tri(o-tolyl)phosphine, and the method using tetrakis(triphenylphosphine)palladium and
cesium carbonate, were studied.

Results:
The selected boronic acids were the classical phenylboronic acid, as well as 4-pyridineand
3-pyridineboronic acids. 26 New biaryl-methoxybenzaldehydes or pyridyl-phenylmethoxybenzaldehydes
have been synthesized, which may be intermediates for pharmaceutically
active compounds.

Conclusion:
The method of Anderson et al. was preferred, because it provides satisfactory results
in all cases.
Cloning Safe Driving Behavior for Self-Driving Cars using Convolutional Neural Networks
Authors: Farag Wael 
Published: November 2018

Background:
In this paper, a Convolutional Neural Network (CNN) to learn safe driving
behavior and smooth steering manoeuvring, is proposed as an empowerment of autonomous driving
technologies. The training data is collected from a front-facing camera and the steering commands
issued by an experienced driver driving in traffic as well as urban roads.

Methods:
This data is then used to train the proposed CNN to facilitate what it is called “Behavioral
Cloning”. The proposed Behavior Cloning CNN is named as “BCNet”, and its deep seventeen-layer
architecture has been selected after extensive trials. The BCNet got trained using Adam’s optimization
algorithm as a variant of the Stochastic Gradient Descent (SGD) technique.

Results:
The paper goes through the development and training process in details and shows the image
processing pipeline harnessed in the development.

Conclusion:
The proposed approach proved successful in cloning the driving behavior embedded in
the training data set after extensive simulations.