bluuebunny/crossref_metadata_2025_split huggingface dataset:
The spectrum and efficacy of antiepileptic drugs in patients with infantile spasms in Russia
Authors: Okhapkina T. G. , Shuljakova I. V. , Ilina E. S. , Kalmykova G. V. , Prytkina M. V. , Belousova E. D. 
Published: August 2018

Recently, the International League Against Epilepsy (ILAE) defined epileptic spasms as a separate type of seizures. According to the international recommendations, the treatment of infantile spasms (IS) begins with hormones or vigabatrin (in the cases of tuberous sclerosis complex – TSC). However, in the Russian Federation, other antiepileptic drugs (AEDs) are often used as the first line medications.Aim:to analyze the current practice of prescribing AEDs for the treatment of epileptic spasms.Materials and Methods. We studied the medical records of 175 patients with IS (59 of them with TSC) hospitalized for the treatment with hormonal therapy.Results.Valproic acid was the most commonly prescribed antiepileptic drug in patients with IS (more than in 80% of cases), both in children with TCS (49/59) and without TCS (102/116). As expected, the clinical effect (cessation of IS and suppression of hypsarrhythmia) of valproic acid was insufficient: it was observed in 9/49 (18.4%) children with TSC and in 12/102 (11.2%) children without TSC. Although ethosuximide, oxcarbazepine, and carbamazepine were known to be ineffective in IS, they were prescribed by medical doctors and taken by IS patients with no clinical improvement at all. Taking into account the possible limitation of this analysis (not all of the children were consulted and hospitalized in our clinics), the real efficacy of AEDs might be some higher.Conclusion. We then conclude that the treatment of IS in the Russian Federation is not in line with the international recommendations and the worldwide clinical practice. There is an urgent need in updating the national standards for the diagnosis and treatment of IS. The work in this direction is now under way in the Russian Federation.
PENGARUH MANAJEMEN PENGETAHUAN, BUDAYA ORGANISASI TERHADAP KINERJA ORGANISASI
Authors: ARFATI ROFIKOTUL 
Published: August 2018

This study aims to examine and analyze the influence of knowledge management and organizational culture on organizational performance. This study uses theory of Resources Based View. The study conducted by the Agency for Assessment and Application of Technology (BPPT), with 62 respondents on engineering positions. Data collected using questionnaire method that is by giving list question or questionnaire which submitted directly to respondent and also by email. Data analysis techniques in this study using Partial Least Square (PLS) with WarpPLS 3.0. The results showed that knowledge management and organizational culture have positive and significant influence on organizational performance.
Keywords : Knowledge Management, Organization Culture, Performance Organization
Retórica, a unidade “louca” de Rousseau?
Authors: Pinto Lúcia Ricotta Vilela 
Published: August 2018

Procurou-se resenhar a leitura do filósofo brasileiro Bento Prado Jr. sobre a obra de Rousseau. Tal leitura constitui-se em importante contribuição na medida em que não circunscreve os escritos de Rousseau à separação entre filosofia e não-filosofia, mas antes aponta para a idéia de que toda a sua obra está centrada num projeto retórico. Projeto este que supõe um “leitor futuro sempre possível” como testemunha do retor. Trata-se de reivindicar uma eloqüência específica nas múltiplas produções teóricas e literárias de Rousseau, e que se desenha na possibilidade da alteridade, na figura do Outro do auditório.
POTENSI JENIS SENGON (Falcataria moluccana (MIQ.) BARNEBY & J.W. GRIMES) DIPERBANYAK MELALUI TEKNIK VEGETATIF (STEK) Potency of Sengon ( Falcataria moluccana (MIQ.) BARNEBY & J.W. GRIMES) Propagation Throught Vegetative Technique (Cutting)
Authors: F. Djam’an Dharmawati , Putri Kurniawati Purwaka , Danu Danu 
Published: August 2018

The sengon plant (Falcataria moluccana (Miq.) Barneby & J.W. Grimes) is the mainstay of community forests, especially in Java. During this time, the seed is used as material for seed production. However, at this time began to find a rust attack puru at the level of seedlings are allegedly carried by seed disease. Therefore, there is a need for other techniques to prevent transmission at the seedling level in the nursery. Vegetative technique is one that can be used to break the path of plant diseases by using healthy ingredients and free from disease. This research is aimed to know the potential of sengon plant to be propagated vegetatively, by cuttings method. The method of cuttings used is shoot cuttings and stem cuttings, and the source of cuttings derived from plants aged 1 and 2 years. The results showed that the highest live percentage was stem cuttings originating from 1 year old plant (34.66%), while the live percentage for stem cuttings originating from 2 year old plants was still very low (3.33%).Keywords: Sengon Plant; Vegetative Propogation; Cutting SourceTanaman sengon (Falcataria moluccana (Miq.) Barneby & J.W. Grimes) merupakan jenis andalan hutan rakyat, khususnya di Pulau Jawa. Selama ini, benih digunakan sebagai bahan untuk produksi bibit. Akan tetapi, saat ini mulai ditemukan serangan karat puru pada tingkat semai yang disinyalir penyakit ini terbawa benih. Oleh karena itu perlu adanya teknik lain untuk mencegah penularan pada tingkat bibit di persemaian. Vegetatif teknik merupakan salah satu yang dapat digunakan untuk memutus jalur penyakit tanaman dengan menggunakan bahan tanaman yang sehat dan bebas dari penyakit. Penelitian ini bertujuan mengetahui potensi tanaman sengon untuk diperbanyak secara vegetative, dengan metode setek. Metode setek yang digunakan adalah setek pucuk dan stek batang, dan sumber bahan stek berasal dari tanaman yang berumur 1 dan 2 tahun. Hasil penelitian menunjukkan bahwa persentase hidup tertinggi adalah pada stek batang yang berasal dari tanaman berumur 1 tahun (34.66%), sedangkan persentase hidup untuk stek batang yang berasal dari tanaman umur 2 tahun masih sangat rendah (3,33%).Kata kunci: Tanaman sengon, perbanyakan vegetative, sumber bahan setek
PENGARUH PERUBAHAN PENGGUNAAN LAHAN TERHADAP KARAKTERISTIK ALIRAN MASUK (INFLOW) BENDUNGAN BATUTEGI The Effect of Land Use Change on the Inflow Characteristics of Batutegi Dam
Authors: Supriyadi Eko , Banuwa Irwan Sukri , Yuwono Slamet Budi 
Published: August 2018

Sekampung Hulu Watershed (DAS) is a catchment area for the Batutegi Dam. Changes in land use due to increasement of human need for land can affect the hydrological conditions of Sekampung Hulu Watershed. This research analyzed land use change to inflow characteristic of Batutegi Dam using descriptive analysis method by analyzing rainfall data, land use change data, inflow data and surface coefficient data. The results showed that there had been decreasing of forest area and the increasing of agriculture land, dry land, and shrubland. It affects the increasing of surface coefficient and decreasing of total inflow. The decrease in total inflow of batutegi dam in 2005 was 7.229,92 m3 / sec and in 2015 was 6.846,82 m3 / sec. This is due to the value of surface runoff coefficient in the Sekampung Hulu Watershed which increased in 2005 and 2015 by 0,23 to 0,34. The amount of surface coefficient value in 2005 and 2015 shows that the Sekampung Hulu Basin has been degraded, therefore it is necessary to restore the condition of the forest through reforestation and greening efforts to increase the water catchment area.Keywords: Sekampung Hulu Watershed; Inflow; Land use change.Daerah Aliran Sungai (DAS) Sekampung Hulu merupakan daerah tangkapan air (catchment area) bagi Bendungan Batutegi. Perubahan penggunaan lahan akibat meningkatnya kebutuhan manusia terhadap lahan dapat berpengaruh terhadap kondisi hidrologi DAS Sekampung Hulu. Penelitian ini menganalisis perubahan penggunaan lahan terhadap karakteristik aliran masuk (inflow) Bendungan Batutegi digunakan metode analisis deskriptif dengan cara manganalisis data curah hujan, data perubahan penggunaan lahan, data inflow dan data koefisien aliran permukaan. Hasil penelitian memperlihatkansudah terjadi penurunan luas hutan dan peningkatan luas pertanian lahan kering, pemukiman, dan semak belukar. Hal tersebut berpengaruh terhadap peningkatan koefisien aliran permukaan dan penurunan total inflow. Penurunan total inflow bendungan batutegi tahun 2005 sebesar 7.229,92 m3/detik dan pada tahun 2015 sebesar 6.846,82 m3/detik. Hal tersebut disebabkan oleh nilai koefisien aliran permukaan di DAS Sekampung Hulu yang mengalami peningkatan pada tahun 2005 dan 2015 sebesar 0,23 menjadi 0,34. Besarnya nilai koefisien aliran permukaan tahun 2005 dan 2015 menunjukkan DAS Sekampung Hulu telah mengalami degradasi, oleh karena itu perlu dilakukan pemulihan kondisi hutan melalui upaya reboisasi maupun penghijauan untuk menambah daerah resapan air.Kata kunci: DAS Sekampung Hulu; Inflow; Perubahan penggunaan Lahan
Discourse on Islamization of Perspective Science
Authors: Asnawan Asnawan 
Published: August 2018

This paper aims to understand and hope about the Islamization of science perspective al Faruqi that disciplines are not regulated and programmed from the sky. Discipline is born from the matrix of a special worldview and hierarchically always subordinated to the worldview. The disciplines of science have no autonomous existence for themselves but evolve according to specific historical and cultural environments and have only a meaning in the world view which gives birth and evolves them. The division of knowledge into the present disciplines is a peculiar manifestation of Western civilization when formulating the problems at hand. For example, the discipline of orientalism was developed because the West regarded Islam as a problem to be studied, analyzed and dictated. Thus, accepting the division of disciplines according to Western epistemology as al Faruqi still does, is synonymous with subordinating the Islamic world-view to Western civilization.
Pendapatan Asli Daerah, Dana Alokasi Umum Dan Dana Alokasi Khusus Terhadap Kinerja Keuangan Pemerintah Kabupaten Gorontalo
Authors: Machmud Joice , Radjak Lukfiah Irwan 
Published: August 2018

This research figures out and analyzes the influence of regency own revenue (PAD), general allocation funds (DAU), and special allocation funds (DAK) on the financial performance of Gorontalo Regency Government, and analyze the dominant variables that affect the Financial Performance of Gorontalo Regency Government. Quantitative approach is applied in this research with multiple regression analysis tools that include Partial Test and simultaneous test. The data used is quantitative internal secondary data, namely LRA period 2012-2016 Gorontalo District Government for all govermental apparatus (SKPD). The results showed that partially, regency own revenue variable (X1) has no significant influence on the value of 0.403 to the financial performance of Gorontalo Regency. General allocation funds variable (X2) has no significant influence with the value of 0.661 on the financial performance of Gorontalo Regency. Special allocation funds (X3) variable has significant influence with significance value 0.000 on financial performance of Gorontalo Regency. It is also shown that simultaneously the independent variables (PAD, DAU and DAK) have a significant effect on the dependent variable, which is the financial performance of Gorontalo Regency Government period 2012-2016 with a significance value of 0.000. It is suggested that further researchers conducting the same study add other variables and use the ratio of local financial independence for performance variables.
Pengaruh Dosis dan Interval Pemupukan Zn-30% terhadap Produksi dan Komponen Hasil Tanaman
Authors: Rezamela Erdiansyah , Rachmiati Yati , Trikamulyana Tito 
Published: August 2018

<em>Zinc deficiency (Zn) in tea </em>[Camellia sinensis<em> (L.) O. Kuntze</em>] <em>may inhibit growth and decreases shoots production. To overcome the deficiency, zinc is generally given in the form of zinc sulphate fertilizer (Zn 22.75%) through foliar application. Today there is a micro-fertilizer with a higher zinc consentration (Zn-30%). The research aimed to determine the effect of dosage and application interval of Zn-30% micro fertilizer on production and yield component of tea shoot. The experiment was conducted in Pasirmalang Estate, Afdeling Wetan Block Pakurendeng II, PT Perkebunan Nusantara VIII Pangalengan Bandung, West Java, altitude ±1,600 m asl, from November 2016 to June 2017. The tea clone used was productive GMB 7. Experiments were designed by randomized block design with 2 factors and 4 replications. The first factor is Zn-30% that consisted of 4 levels i.e. Zn-30% with a dose of 300, 250, and 200 g/ha respectively, and ZnSO<sub>4</sub> with a dose of 2 kg as control. The second factor is interval of application that consisted of 2 levels, once and twice applications after plucking. Variables observed were production and yield components of tea shoot. The results showed that application of Zn-30% with a dose of 300 g/ha in one time interval of application after plucking effectively increased shoot production compared to other doses, but not significantly different with </em><em>ZnSO<sub>4</sub> in two time interval of application. Application of Zn, either in the form of oxide salt or zinc sulphate, increased the percentage of pecco shoots and reduces number of banji shoots.</em>
The Effects of Curcumin on Glycemic Control and Lipid Profiles Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Metaanalysis of Randomized Controlled Trials
Authors: Tabrizi Reza , Vakili Sina , Lankarani Kamran B. , Akbari Maryam , Mirhosseini Naghmeh , Ghayour-Mobarhan Majid , Ferns Gordon , Karamali Fatemeh , Karamali Maryam , Taghizadeh Mohsen , Kouchaki Ebrahim , Asemi Zatollah 
Published: August 2018

Background:
This systematic review and meta-analysis of randomized controlled trials (RCTs), were
performed to determine the effects of curcumin intake on glycemic control and lipid profiles among patients with
metabolic syndrome (MetS) and related disorders.

Methods:
We searched the following databases up until January 2018: MEDLINE, EMBASE, Web of Science,
and Cochrane Central Register of Controlled Trials. The relevant data were extracted and evaluated for quality of
the studies in accordance with the Cochrane risk of bias tool. Data were pooled using the inverse variance method
and expressed as standardized mean difference (MDs) with 95% confidence intervals (95% CI).

Results:
Twenty-six trials with 1890 participants were included in the current meta-analysis. The findings demonstrated
the significant association between curcumin intake and reduced fasting glucose levels (SMD -0.78;
95% CI, -1.20, -0.37; P<0.001), homeostasis model of assessment-estimated insulin resistance (SMD -0.91; 95%
CI, -1.52, -0.31; P=0.003) and HbA1c (SMD -0.92; 95% CI, -1.37, -0.47; P<0.001). In addition, curcumin supplementation
was significantly associated with triglyceride (SMD -1.21; 95 % CI, -1.78, -0.65; P<0.001) and total
cholesterol reduction (SMD -0.73; 95 % CI, -1.32, -0.13; P= 0.01). However, curcumin intake significantly increased
insulin levels (SMD 0.92; 95% CI, 0.06, 1.78; P=0.036). We found no significant effect of curcumin
supplementation on LDL- (SMD -0.52; 95% CI, -1.14, 0.11; P=0.10) and HDL-cholesterol levels (SMD 0.28;
95% CI, -0.22, 0.77; P=0.27).

Conclusion:
Overall, curcumin consumption was associated with a significant reduction in fasting glucose,
HOMA-IR, HbA1c, triglycerides and total cholesterol levels among patients with MetS and related disorders, but
did not affect LDL- and HDL-cholesterol levels.
Identification of Phenolic Compounds from Nettle as New Candidate Inhibitors of Main Enzymes Responsible on Type-II Diabetes
Authors: Salim Bouchentouf , Said Ghalem , Kambouche Nadia , Kress Soumaya 
Published: August 2018

Background:
In medicinal chemistry, the discovery of small organic molecules that can
be optimized and lead to a future drug capable of effectively modulating the biological activity of a
therapeutic target remains a major challenge. Because of the harmful secondary effects of synthesized
therapeutic molecules, the development of research has been oriented towards phytomedicines.
Phenolic compounds from medicinal plants are constantly explored for new therapeutic use.

Methods:
In this paper, we studied interactions between main enzymes responsible for causing
type 2 diabetes mellitus (T2DM) and phenolic compounds from nettle (Urtica dioica L.) using molecular
Docking with Molecular Operating Environment Software (MOE).

Results:
Docking results show a common molecule (secoisolariciresinol), which may form stable
complexes with depeptidyl peptidase 4 (DPP-4), alpha-amylase and beta-glucosidase with binding
energy of -7.04732084 kcal/mol, -3.82946181 kcal/mol and -4.16077089 kcal/mol respectively.
Besides secoisolariciresinol, other phenolic compounds give better docking score than the original
co-crystallized ligand for alpha-amylase (PDB ID 5U3A) and beta-glucosidase (PDB ID 1OGS).

Conclusion:
The obtained results are promising for the discovery of new alpha-amylase and betaglucosidase
inhibitors. This study also confirms the folk use of nettle as antidiabetic agent.
Isolation and Identification of Certain Phenolic Compounds from Salix mucronata Leaf Extracts and Evaluation Them as Antimicrobial Agents
Authors: El-Sayed Mortada M. , Abdel-Aziz Maher M. , Abo-Sedra Salah , Mohamed Heba R. , Abdel-Lateef Ezzat E.-S. 
Published: August 2018

Background:
In recent years, plant extracts are considered as an important source of many
drug formulations for treatment of human beings from infection diseases. The objective of this study
was to evaluate the antimicrobial activity of Salix mucronata leaves extracts and isolate their bioactive
phytochemicals.

Methods:
The dry powder of Salix mucronata was extracted with different aqueous methanol concentrations.
The 85% methanolic extract was further fractionated using different organic solvents. The antimicrobial
activity of different extracts and fractions was evaluated. The most bioactive fractions were
submitted for chromatographic isolation and structure elucidation of their phytochemicals using chromatographic
and spectroscopic methods.

Results:
The ethyl acetate and the butanolic fractions derived from 85% MeOH extract gave a high
antimicrobial activity with inhibition zones ranging between 10 mm and 26 mm and minimum inhibitory
concentration (MIC) value of 8 mg/mL. While the butanolic fraction showed zones of inhibition
ranging between 10 mm and 25 mm with MIC 8 mg/mL. Six compounds were isolated from ethyl acetate
fraction and their structures were elucidated as; apigenin (1), quercetin (2), quercetrin (3), rhamnazin
-3-O-β-D-glucopyranoside (4), Chrysoeriol-7-O-β-D-glucuronoid- 6ʺ -methyl ester (5), and tremuloidin
(6). Also, five compounds were isolated from the butanolic fraction and their structures were
elucidated as; kaempferol (7), luteolin (8), luteolin-3ʹ - methoxy-4ʹ - O-β-D- glucopyranoside (9),
isorhamnetin -3-O-β -D-glucopyranoside (10) and salicin (11).

Conclusion:
The results of the present study showed that the ethyl acetate and the butanolic fractions
contain high flavonoids and salicinoids compounds which may attribute to their potential as antimicrobial
agents.
Detection Method of Environmentally Friendly Non-POP PBDEs by Derivatization-Enhanced Raman Spectroscopy Using the Pharmacophore Model
Authors: Zhang Shujing , Qiu Youli , Li Yu 
Published: August 2018

Background:
Polybrominated diphenyl ethers (PBDEs) are dangerous for the environment
and human health because of their persistent organic pollutant (POP) characteristics, which have attracted
extensive research attention. Raman spectroscopy is a simple highly sensitive detection operation.
This study was performed to obtain environmentally friendly non-POP PBDE derivatives with
simple detection-based molecular design and provide theoretical support for establishing enhanced
Raman spectroscopic detection techniques.

Methods:
A three-dimensional quantitative structure-activity relationship (3DQSAR) pharmacophore
model of characteristic PBDE Raman spectral was established using 20 and 10 PBDEs as training and
test sets, respectively. Full-factor experimental design was used to modify representative commercial
PBDEs, and their flame retardancy and POP characteristics were evaluated.

Results:
The pharmacophore model (Hypo1) exhibited good predictive ability with the largest correlation
coefficient (R2) of 0.88, the smallest root mean square (RMS) value of 0.231, and total cost of
81.488 with a configuration value of 12.56 (˂17).74 monosubstituted and disubstituted PBDE derivatives
were obtained based on the Hypo 1 pharmacophore model and full-factor experimental design auxiliary.
Twenty PBDE derivatives were screened, and their flame-retardant capabilities were enhanced and
their migration and bio-concentration were reduced (log(KOW) <5), with unchanged toxicity and high
biodegradability. The Raman spectral intensities increased up to 380%. In addition, interference analysis
of the Raman peaks by group frequency indicated that the 20 PBDE derivatives were easily detected
with no interference in gaseous environments.

Conclusion:
Nine pharmacophore models were constructed in this study; Hypo 1 was the most accurate.
Twenty PBDE derivatives showed Raman spectral intensities increased up to 380%; these were
classified as new non-POP environmentally friendly flame retardants with low toxicity, low migration,
good biodegradability, and low bio-concentrations. 2D QSAR analysis showed that the most positive
Milliken charge and lowest occupied orbital energy were the main contributors to the PBDE Raman
spectral intensities. Raman peak analysis revealed no interference between the derivatives in gaseous
environments.