bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of time lag and photon index in GX 339-4
Authors: Kylafis Nikolaos D. , Reig Pablo 
Published: June 2018

Context. Black hole transients, as a class, exhibit during their outbursts a correlation between the time lag of hard photons with respect to softer ones and the photon index of the hard X-ray power law. The correlation is not very tight and therefore it is necessary to examine it source by source.
Aims. The objective of the present work is to investigate in detail the correlation between the time lag and the photon index in GX 339-4, which is the best studied black hole transient.
Methods. We have obtained RXTE energy spectra and light curves and have computed the photon index and the time lag of the 9–15 keV photons with respect to the 2–6 keV photons. The observations cover the first stages of the hard state, the pure hard state, and the hard-intermediate state.
Results. We have found a tight correlation between time lag and photon index Γ in the hard and hard-intermediate states. At low Γ, the correlation is positive; it becomes negative at high Γ By assuming that the hard X-ray power-law index Γ is produced by inverse Compton scattering of soft disk photons in the jet, we have reproduced the entire correlation by varying two parameters in the jet: the radius of the jet at its base R0 and the Thomson optical depth along the jet τ∥. We have found that as the luminosity of the source increases, R0 initially increases and then decreases. This behavior is expected in the context of the Cosmic Battery.
Conclusions. Our jet model nicely explains the correlation with reasonable values of the parameters R0 and τ∥ These parameters also correlate between themselves. As a further test of our model, we predict the break frequency in the radio spectrum as a function of the photon index during the rising part of an outburst.
Recurrent Corneal Erosions in Corneal Dystrophies: a Review of the Pathogenesis, Differential Diagnosis, and Therapy
Authors: Omari Amro , Mian Shahzad 
Published: June 2018

Abstract
Introduction Recurrent corneal erosions in corneal dystrophies are visually significant and bothersome to patients. The goal of this article is to review the pathogenesis, differential diagnosis, and management of recurrent corneal erosions in corneal dystrophies.
Patients and Methods Forty-eight articles and 1 textbook recently published on corneal erosions in corneal dystrophies were reviewed. The findings on the pathogenesis and clinical characteristics of erosions in each dystrophy were summarized. Any contradicting opinions for which the literature was unclear were either omitted or recorded as lacking strong evidence.
Results and Conclusions The epithelial-stromal complex plays an important role in the pathogenesis of erosions in corneal dystrophies. The clinical features of each corneal dystrophy guide their diagnosis and management. A better understanding of the pathogenesis and clinical features of erosions in corneal dystrophies can lead to better clinical outcomes.
Arthroscopic Reconstruction of Intratendinous Lesions of the Supraspinatus Tendon – a Systematic Review
Authors: von Knoch Marius , Frosch Stephan , Lehmann Wolfgang 
Published: June 2018

Abstract
Background Intratendinous lesions of the rotator cuff of the shoulder are frequent and may be a distinct clinical entity. Nevertheless, there are only a few publications which deal specifically with this subject. This study analyses the existing literature for the arthroscopic reconstruction of the intratendinous lesion of the supraspinatus tendon, by means of a systematic review, and identifies relevant research questions for future studies.
Material and Methods In January 2017, a systematic review of the U. S. National Library of Medicine/National Institutes of Health (PubMed) Database and the Cochrane Library was conducted using the PRISMA checklist. The search words were “supraspinatus” and “interstitial”; “supraspinatus”, “tear” and “intratendinous”; “supraspinatus” and “concealed”. In the course of the review, articles written in English with at least a partial arthroscopic case series dealing with the reconstruction of the supraspinatus tendon were identified and further analysed.
Results Primarily 70 hits could be generated. Five articles met the inclusion criteria and were analysed in detail. The number of arthroscopic cases ranged between 6 and 33. Level of evidence was IV in all studies. The diagnosis of an intratendinous lesion was made by MR imaging when T2/fat-saturated sequences showed an intratendinous high intensity signal without disruption of the bursal or articular layer. Three different concepts were followed in surgical treatment: opening of the intratendinous lesion from the bursal or articular side or by complete resection of the lesion. The reconstruction was performed with suture anchors in all cases. In the majority of cases, an acromioplasty was also performed. The reported clinical results were mostly good. Healing of the tendon was shown by MR imaging in 81.5 to 100% of cases.
Conclusion After failure of conservative treatment, symptomatic intratendinous lesions of the supraspinatus tendon can be localised intraoperatively and reconstructed after failure of conservative treatment. The expected results are good in the medium term. The evidence level of the studies analysed was low. Future studies should examine the role of alternative conservative and surgical therapies.
Unterschiede zwischen der stationären Komplikationsdichte nach einer Ureterorenoskopie und dem durch Patienten berichteten 30 Tages-Outcome – Ergebnisse der deutschen prospektiven BUSTER-Studie
Authors: Wolff Ingmar , May Matthias , Hoschke Bernd , Gilfrich Christian , Peter Julia , Ecke Thorsten , Schostak Martin , Lebentrau Steffen 
Published: June 2018

Zusammenfassung
Hintergrund Patienten nach Ureterorenoskopie (URS) werden nach kurzem stationären Aufenthalt entlassen, die Einschätzung der Komplikationsdichte basiert auf der Betrachtung dieses kurzen Zeitfensters. Mit Daten der prospektiven BUSTER-Studie (Bewertung der ureterorenoskopischen Steintherapie – Ergebnisse hinsichtlich Komplikationen, Lebensqualität und Steinfreiheitsrate) sollen hier der Zusammenhang der Komplikationsschwere im stationären und 30-Tages-Verlauf (30-TV) sowie Einflussfaktoren auf die Lebensqualität (LQ) nach Entlassung aus stationärer Behandlung untersucht werden.
Material und Methoden 01/2015 – 04/2015 wurden an 14 deutschen Kliniken Daten von 307 Patienten mit URS als Steintherapie gesammelt. Zudem wurden Komplikationen nach Clavien-Dindo-Graden (CDG) und Angaben zur LQ 30 Tage postoperativ durch Patientenfragebögen erfasst, die von 169/307 Patienten vorlagen. Es wurden drei Subgruppen gebildet: keine Zunahme der CDG im 30-TV (n = 128), Zunahme der CDG ohne Interventionsbedarf (n = 39), Zunahme der CDG mit Interventionsbedarf (n = 2). Der Zusammenhang zwischen diesen Kategorien und den Angaben zur LQ wurde durch Rangsummenkorrelation nach Spearman (ρ) geprüft. Der Einfluss klinischer Parameter auf den Endpunkt „Zunahme der CDG im 30-TV“ wurde mit einem multivariaten logistischen Regressionsmodell untersucht.
Ergebnisse Während des stationären Aufenthalts traten bei 13 Patienten (7,7 %) Komplikationen auf (meist CDG1), 30 Tage postoperativ berichteten 43 Patienten (25,4 %) über Komplikationen (davon 16 CDG2, zwei CDG3). Zwischen einer Zunahme der CDG und allen Aspekten der LQ bestand eine statistisch signifikante Korrelation, am deutlichsten bei Angaben zu Schmerzen (ρ = 0,425; p < 0,001). Nur die Steingröße hatte unabhängigen Einfluss auf den Endpunkt „Zunahme der CDG im 30-TV“ (OR: 1,09; 95 %-KI 1,01 – 1,17; p = 0,040). Die Stenteinlage nach URS hatte bei bemerkenswerter Odds Ratio keinen signifikanten Einfluss auf diesen Endpunkt (OR: 4,19; 95 %-KI 0,64 – 27,32; p = 0,134), was durch eine erhebliche Ungleichverteilung dieses Kriteriums erklärt werden könnte (86,4 % Stent nach URS).
Schlussfolgerungen Betrachtungen zu URS-Komplikationen sollten über die stationäre Behandlung hinaus erfolgen, da es im 30-TV zu einer Zunahme der Komplikationsdichte korrelierend mit einer Verschlechterung der LQ kam. Ob der Verzicht auf die Stenteinlage nach URS zu einer geringeren Komplikationsdichte und besseren LQ beitragen kann, muss durch weitere Studien untersucht werden.
Fibrinolytic Activator, Glutamic Oxaloacetic Transaminase and Potassium in Myocardial Tissue at Various Stages of Human Myocardial Infarction
Authors: Fischer Simon , Albrechtsen Ole K. , Bang Nils U. 
Published: June 2018

Summary1. The concentrations of GO transaminase, potassium and plasminogen activator have been estimated in tissue homogenates from different zones of 7 human myocardial infarcts of varying age.2. Significantly decreased values for GO transaminase, plasminogen activator and potassium were found in areas with fully developed necrosis.3. Ischemic areas showed a less marked but significant decrease in GO transaminase and potassium concentrations, whereas the plasminogen activator was normal or slightly increased.4. Fibrosed infarcts showed increased concentrations of plasminogen activator.
A Study of the Role of Hemolysis in the Hemostatic Defect of Transfusion Reactions
Authors: Langdell R. D , Hedgpeth E. M 
Published: June 2018

SummaryHemoglpbinemia of approximately 300 mg% was produced in dogs by five separate methods. Resulting from the infusions of incompatible plasma or erythrocytes there was a hemostatic defect characterized by severe thrombocytopenia and moderate fibrinogenopenia. Associated with this were leukopenia, neuromuscular and cardio-respiratory disturbances. Except for hemoglobinemia resulting from infusion of autologous hemoglobin solution, distilled water, or glucose-damaged autologous erythrocytes, no systemic reaction was detected. These findings indicate that the liberation of thromboplastic erythrocyte components by hemolysis is not the mechanism of the hemostatic defect in hemolytic transfusion reactions.Acknowledgment. Canine anti-A serum was obtained through the courtesy of Lt. Col. J. H. Akeroyd, Walter Reed Army Institute of Research, Washington, D. C.
The Separation of AHF from Fibrinogen
Authors: van Creveld S , Veder H. A , Pascha C. N , Kroeze W. F 
Published: June 2018

SummaryAnti-haemophilic globulin and fibrinogen of both bovine and human origin could be separated on columns of DEAE-cellulose. The yield of bovine AHF was high in contrast to that of human AHF, but further work to improve this yield is in progress.
Studies on the Fate of Coagulation Factors during the Clotting of Normal and Pathological Blood
Authors: Hougie Cecil 
Published: June 2018

SummaryIn a mild case of Stuart factor (SF) deficiency and in a patient with hemophilia B (factor IX deficiency) consumption of AHF (factor VIII) was normal but was abnormal in more severe examples of these diseases. This finding reconciles previously conflicting reports. Factor V utilisation was abnormal in moderately severe cases of SF deficiency, hemophilia A and hemophilia B but normal in mild cases of SF deficiency and hemophilia B. A mild case of hemophilia A was not studied. These findings would be expected from the modern concept of blood coagulation. However, the findings with respect to AHF are equally well explained if AHF is destroyed by some intermediate product of blood coagulation, such as thrombin, appearing at the time of the appearance of fibrin.The concentration of SF was found to remain constant during the clotting of both normal blood and blood deficient in factor VILThe concentration of factor VII during the coagulation of normal blood remained constant until the appearance of fibrin. The concentration then increased, but this finding was not consistently obtained. No abnormality in the fate of factor VII during the clotting of blood deficient in SF was found.
Rôle du Facteur Contact (Facteur Hageman) dans la Fibrinolyse
Authors: Niewiarowski S , Prou-Wartelle O 
Published: June 2018

RésuméL’agitation d’un plasma intact en présence de surfaces activant le facteur Hageman: kaolin (1 mg/cm3), célite (1 mg/cm3), ballotini (20 mg/cm3), bentonite (1 mg/cm3), accélère la fibrinolyse à condition que le taux de facteur Hageman soit normal dans les plasmas étudiés.L’activation du système fibrinolytique d’un plasma intact agité avec kaolin ou célite est très importante avec plasma normal, le plasma d’hémophile A, le plasma d’hémophile B, le plasma d’hypoconvertinémie, le plasma dicoumarolé et le plasma de déficit en PTA.Le système fibrinolytique du plasma de Hageman-trait n’est pas activable dans les mêmes conditions, bien que le taux de plasminogène et d’antiplasmine soit normal et que ce plasma n’inhibe pas l’activation de la fibrinolyse d’un plasma normal. Les mêmes constatations sont faites en utilisant un plasma privé artificiellement du facteur contact (“plasma épuisé”).Ces résultats sont discutés, et les auteurs se demandent si l’absence de fibrinolyse physiologique chez les sujets porteurs de Hageman-trait ne pourrait pallier au trouble de la coagulation et peut-être expliquer l’absence d’hémorragie.
Cortisone und thromboembolische Komplikationen
Authors: Siegenthaler W , Isler U 
Published: June 2018

ZusammenfassungEs wird über 12 Patienten berichtet, wovon 7 Fälle mit Neoplasien und 5 Fälle mit nicht tumorösen Krankheiten, bei denen im Verlaufe einer Behandlung mit Cortisonen ein thromboembolischer Zwischenfall eingetreten ist. Bei 2 Kranken erfolgte der Tod an den Folgen einer massiven Lungenembolie. 8 weitere Patienten erlagen vorwiegend dem Grundleiden, doch stellten die thrombo-embolischen Veränderungen einen wichtigen Nebenbefund dar. Zusammen mit den experimentellen Untersuchungen und klinischen Beobachtungen anderer Autoren darf angenommen werden, daß den Cortisonen bei der Entwicklung thromboembolischer Komplikation eine ursächliche Bedeutung beigemessen werden darf, zumal es sich dabei teilweise um Affektionen mit Neigung zu hämorrhagischer Diathese gehandelt hat. Der Synergismus von hochgradiger Hypercholesterinämie und Cortisonwirkung scheint sich besonders ungünstig auszuwirken.Es ergibt sich die praktische Forderung, bei jeder Cortisonbehandlung auf Thrombosesymptome zu achten, um eine möglichst frühzeitige Thrombosetherapie mit Antikoagulantien einleiten zu können. Bei Anwesenheit anderer die Thrombose begünstigender Faktoren, z. B. Hypercholesterinämie, ist mit der Cortisonbehandlung eine gleichzeitige Antikoagulantienprophylaxe durchzuführen.
A Standardized Approach for Category II Fetal Heart Rate with Significant Decelerations: Maternal and Neonatal Outcomes
Authors: Shields Laurence , Wiesner Suzanne , Klein Catherine , Pelletreau Barbara , Hedriana Herman 
Published: June 2018

Objective To determine if a standardized intervention process for Category II fetal heart rates (FHRs) with significant decels (SigDecels) would improve neonatal outcome and to determine the impact on mode of delivery rates.
Study Design Patients with Category II FHRs from six hospitals were prospectively managed using a standardized approach based on the presence of recurrent SigDecels. Maternal and neonatal outcomes were compared between pre- (6 months) and post-(11 months) implementation. Neonatal outcomes were: 5-minute APGAR scores of <7, <5, <3, and severe unexpected newborn complications (UNC). Maternal outcomes included primary cesarean and operative vaginal birth rates of eligible deliveries.
Results Post implementation there were 8,515 eligible deliveries, 3,799 (44.6%) were screened, and 361 (9.5%) met criteria for recurrent SigDecels. Compliance with the algorithm was 97.8%. The algorithm recommended delivery in 68.0% of cases. Relative to pre-implementation, 5-minute APGAR score of <7 were reduced by 24.6% (p < 0.05) and severe UNC by −26.6%, p = < .05. The rate of primary cesarean decreased (19.8 vs 18.3%, p < 0.05), while there were nonsignificant increases in vaginal (74.6 vs 75.8%, p = 0.13) and operative vaginal births (5.7 vs 5.9%, p = 0.6).
Conclusion Standardized management of recurrent SigDecels reduced the rate of 5-minute APGAR scores of < 7 and severe UNC.
Potential adverse cardiac remodelling in highly trained athletes: still unknown clinical significance
Authors: Gabrielli Luigi , Sitges Marta , Chiong Mario , Jalil Jorge , Ocaranza María , Llevaneras Silvana , Herrera Sebastian , Fernandez Rodrigo , Saavedra Rodrigo , Yañez Fernando , Vergara Luis , Diaz Alexis , Lavandero Sergio , Castro Pablo 
Published: June 2018

AbstractModerate endurance exercise has long been considered an essential element to maintain cardiovascular health, and sedentary behaviour in the general population has been related to a significant increase in all‐causes of mortality, cardiovascular disease mortality and cardiovascular disease incidence. However, a growing group of people performs an intense exercise that leads to multiple heart adaptive changes that are collectively called “athlete's heart”. In this review, we discussed the evidence of cardiac remodelling process secondary to repetitive and strenuous exercise in some predisposed athletes that produces intense and probably deleterious changes in cardiac morphology and function with no clear clinical significance in long‐term follow‐up. Moreover, we also discussed the individual biological response to exercise assessed by myocardial damage, inflammation, oxidative stress, fibrosis and ventricular hypertrophy biomarkers showing different intensities with equivalent exertion.
Relationship between accuracy and complexity when learning underarm precision throwing
Authors: Valle Maria Stella , Lombardo Luciano , Cioni Matteo , Casabona Antonino 
Published: June 2018

AbstractLearning precision ball throwing was mostly studied to explore the early rapid improvement of accuracy, with poor attention on possible adaptive processes occurring later when the rate of improvement is reduced. Here, we tried to demonstrate that the strategy to select angle, speed and height at ball release can be managed during the learning periods following the performance stabilization. To this aim, we used a multivariate linear model with angle, speed and height as predictors of changes in accuracy. Participants performed underarm throws of a tennis ball to hit a target on the floor, 3.42 m away. Two training sessions (S1, S2) and one retention test were executed. Performance accuracy increased over the S1 and stabilized during the S2, with a rate of changes along the throwing axis slower than along the orthogonal axis. However, both the axes contributed to the performance changes over the learning and consolidation time. A stable relationship between the accuracy and the release parameters was observed only during S2, with a good fraction of the performance variance explained by the combination of speed and height. All the variations were maintained during the retention test. Overall, accuracy improvements and reduction in throwing complexity at the ball release followed separate timing over the course of learning and consolidation.
GeneSpy, a user-friendly and flexible genomic context visualizer
Authors: Garcia Pierre Simon , Jauffrit Frédéric , Grangeasse Christophe , Brochier-Armanet Céline 
Published: June 2018

Abstract

Summary
The exploration and comparison of genome organization is routinely used in the frame of genomic and phylogenomic analyses. As a consequence, in the past few years, various tools allowing visualizing genomic contexts have been developed. However, their use is often hampered by a lack of flexibility, particularly concerning associated databases input formats and figure customization. Here we present GeneSpy, a graphical user interface that allows the visualization and dynamic exploration of eukaryotic and prokaryotic annotated genomes. GeneSpy relies on user-friendly manageable local databases and allows the easy customization and production of figures in a multitude of formats.

Availability and implementation
GeneSpy is freely available at https://lbbe.univ-lyon1.fr/GeneSpy/ for Linux, Mac OS and Windows under CeCILL license (http://www.cecill.info/licences/). It is written in Python 2.7 and depends on Matplotlib, Tkinter and Sqlite libraries.

Supplementary information
Supplementary data are available at Bioinformatics online.
Prioritizing predictive biomarkers for gene essentiality in cancer cells with mRNA expression data and DNA copy number profile
Authors: Guan Yuanfang , Li Tingyang , Zhang Hongjiu , Zhu Fan , Omenn Gilbert S 
Published: June 2018

Abstract

Motivation
Finding driver genes that are responsible for the aberrant proliferation rate of cancer cells is informative for both cancer research and the development of targeted drugs. The established experimental and computational methods are labor-intensive. To make algorithms feasible in real clinical settings, methods that can predict driver genes using less experimental data are urgently needed.

Results
We designed an effective feature selection method and used Support Vector Machines (SVM) to predict the essentiality of the potential driver genes in cancer cell lines with only 10 genes as features. The accuracy of our predictions was the highest in the Broad-DREAM Gene Essentiality Prediction Challenge. We also found a set of genes whose essentiality could be predicted much more accurately than others, which we called Accurately Predicted (AP) genes. Our method can serve as a new way of assessing the essentiality of genes in cancer cells.

Availability and implementation
The raw data that support the findings of this study are available at Synapse. https://www.synapse.org/#! Synapse: syn2384331/wiki/62825. Source code is available at GitHub. https://github.com/GuanLab/DREAM-Gene-Essentiality-Challenge.

Supplementary information
Supplementary data are available at Bioinformatics online.
13Check_RNA: a tool to evaluate 13C chemical shift assignments of RNA
Authors: Icazatti A A , Martin O A , Villegas M , Szleifer I , Vila J A 
Published: June 2018

Abstract

Motivation
Chemical shifts (CS) are an important source of structural information of macromolecules such as RNA. In addition to the scarce availability of CS for RNA, the observed values are prone to errors due to a wrong re-calibration or miss assignments. Different groups have dedicated their efforts to correct CS systematic errors on RNA. Despite this, there are not automated and freely available algorithms for evaluating the referencing of RNA 13 C CS before their deposition to the BMRB or re-reference already deposited CS with systematic errors.

Results
Based on an existent method we have implemented an open source python module to correct 13 C CS (from here on 13Cexp) systematic errors of RNAs and then return the results in 3 formats including the nmrstar one.

Availability and implementation
This software is available on GitHub at https://github.com/BIOS-IMASL/13Check_RNA under a MIT license.

Supplementary information
Supplementary data are available at Bioinformatics online.