bluuebunny/crossref_metadata_2025_split huggingface dataset:
A cabinet of the ordinary: domesticating veterinary education, 1766–1799
Authors: HEINTZMAN KIT 
Published: April 2018

AbstractIn the late eighteenth century, the Ecole vétérinaire d'Alfort was renowned for its innovative veterinary education and for having one of the largest natural history and anatomy collections in France. Yet aside from a recent interest in the works of one particular anatomist, the school's history has been mostly ignored. I examine here the fame of the school in eighteenth-century travel literature, the historic connection between veterinary science and natural history, and the relationship between the school's hospital and its esteemed cabinet. Using the correspondence papers of veterinary administrators, state representatives and competing scientific institutions during the French Revolution, I argue that resource constraints and the management of anatomical and natural history specimens produced new disciplinary boundaries between natural history, veterinary medicine and human medicine, while reinforcing geographic divisions between the local and the foreign in the study of non-human animals. This paper reconstructs theAncien Régimereasoning that veterinary students would benefit from a global perspective on animality, and the Revolutionary government's rejection of that premise. Under republicanism, veterinary medicine became domestic.
Can the tea tree oil (Australian native plant:Melaleuca alternifolia Cheel) be an alternative treatment for human demodicosis on skin?
Authors: Lam Nelson Siu Kei , Long Xin Xin , Griffin Robert C , Chen Mu-Kai , Doery James CG 
Published: April 2018

AbstractAustralian tea tree oil (TTO) and its extract terpinen-4-ol (T4O) are found to be effective in moderating demodex-related diseases. Their possible effects are lowering the mite counts, relieving the demodex-related symptoms and modulating the immune system especially the inflammatory response. This review summarizes the topical treatments of TTO and T4O in human demodicosis, their possible mechanism of actions, side-effects and potential resistance in treating this condition. Although current treatments other than TTO and T4O are relatively effective in controlling the demodex mite population and the related symptoms, more research on the efficacy and drug delivery technology is needed in order to assess its potential as an alternative treatment with minimal side-effect profile, low toxicity and low risk of demodex resistance.
The king of dirt: public health and sanitation in late medieval Ghent
Authors: COOMANS JANNA 
Published: April 2018

ABSTRACT:Taking the office of theconinc der ribaudenin Ghent as a case-study, this article reconstructs the enforcement of urban sanitation and preventative health practices during the fourteenth and fifteenth centuries. Theconincmanaged a wide range of issues perceived as potentially polluting, damaging or threatening to health. Banning waste and chasing pigs as well as prostitutes off the streets, the office implemented a governmental vision on communal well-being. Health interests, as part of a broader pursuit of the common good, therefore played an important yet hitherto largely overlooked role in medieval urban governance.
Caregiver perceptions of a fruit and vegetable prescription programme for low-income paediatric patients
Authors: Saxe-Custack Amy , Lofton Heather Claire , Hanna-Attisha Mona , Victor Colleen , Reyes Gwendolyn , Ceja Tiffany , LaChance Jenny 
Published: April 2018

AbstractObjectiveThe physical and social environments that surround children should support good health. However, challenges with food security and access prevent many children from consuming a healthy diet, which is critical to proper growth and development. The present study sought to gain a better understanding of primary care initiatives to address these issues in a low-income setting.DesignFollowing the relocation of a paediatric clinic to a farmers’ market building and the implementation of a fruit and vegetable prescription programme, researchers conducted thirty-two semi-structured interviews with caregivers. Researchers elicited caregivers’ perceptions of clinic co-location with the farmers’ market; experiences with the prescription programme; opinions of the farmers’ market; and perceived impact on child consumption of fresh produce. Interview recordings were transcribed for textual analysis. Using thematic analysis, researchers examined qualitative data to identify patterns across transcripts and formulate emerging themes. Researchers concluded when data saturation was reached.SettingFlint, Michigan, USA.SubjectsThe majority of participants were female (91 %) and African American (53 %).ResultsFour recurrent themes emerged during interviews: (i) convenience of relocation; (ii) attitude towards prescription programme; (iii) challenges with implementation; and (iv) perceived impact of combined interventions. Caregivers indicated that the co-location and prescription programme increased family shopping at the farmers’ market, improved access to high-quality produce and improved food security.ConclusionsA fruit and vegetable prescription programme involving a partnership between a farmers’ market and paediatric clinic was perceived as effective in improving food security, food access and child consumption of fresh fruits and vegetables.
Antimicrobial resistance: from basic science to translational innovation
Authors: Lin Jun 
Published: April 2018

AbstractThe rise in antimicrobial resistance (AMR) poses a major threat to animal agriculture and human health. To summarize and update current and emerging AMR issues that are significant for animal health and food safety, this issue presents a virtual AMR symposium consisting of seven review papers. These reviews cover a newly described AMR mechanism in Campylobacter, effects of AMR and microbiome on Campylobacter infection, plasmid-mediated colistin resistance in food-producing animals, the impact of point source or antibiotic residues on the environmental resistome, and potential factors influencing horizontal gene transfer in the intestines of food animals. These papers also identify significant knowledge gaps in AMR research and provide new directions for the development of innovative and effective strategies to mitigate AMR in the animal production system.
Maternal intake of omega-3 and omega-6 polyunsaturated fatty acids during mid-pregnancy is inversely associated with linear growth
Authors: Al-Hinai M. , Baylin A. , Tellez-Rojo M. M. , Cantoral A. , Ettinger A. , Solano-González M. , Peterson K. E. , Perng W. 
Published: April 2018

AbstractThis study investigates relations of maternal N-3 and N-6 polyunsaturated fatty acids (PUFA) intake during pregnancy with offspring body mass index (BMI), height z-score and metabolic risk (fasting glucose, C-peptide, leptin, lipid profile) during peripuberty (8–14 years) among 236 mother–child pairs in Mexico. We used food frequency questionnaire data to quantify trimester-specific intake of N-3 alpha-linolenic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA); N-6 linoleic acid and arachidonic acid (AA); and N-6:N-3 (AA:EPA+DHA), which accounts for the fact that the two PUFA families have opposing effects on physiology. Next, we used multivariable linear regression models that accounted for maternal education and parity, and child’s age, sex and pubertal status, to examine associations of PUFA intake with the offspring outcomes. In models where BMI z-score was the outcome, we also adjusted for height z-score. We found that higher second trimester intake of EPA, DHA and AA were associated with lower offspring BMI and height z-score. For example, each 1-s.d.increment in second trimester EPA intake corresponded with 0.25 (95% CI: 0.03, 0.47) z-scores lower BMI and 0.20 (0.05, 0.36) z-scores lower height. Accounting for height z-score in models where BMI z-score was the outcome attenuated estimates [e.g., EPA: −0.16 (−0.37, 0.05)], suggesting that this relationship was driven by slower linear growth rather than excess adiposity. Maternal PUFA intake was not associated with the offspring metabolic biomarkers. Our findings suggest that higher PUFA intake during mid-pregnancy is associated with lower attained height in offspring during peripuberty. Additional research is needed to elucidate mechanisms and to confirm findings in other populations.
Maternal anxiety, depression and sleep disorders before and during pregnancy, and preschool ADHD symptoms in the NINFEA birth cohort study
Authors: Vizzini L. , Popovic M. , Zugna D. , Vitiello B. , Trevisan M. , Pizzi C. , Rusconi F. , Gagliardi L. , Merletti F. , Richiardi L. 
Published: April 2018

Aims.Maternal mental disorders have been associated with the risk of attention-deficit/hyperactivity disorder (ADHD) in children. Within the context of a mother–child cohort, we examined whether maternal anxiety, depression and sleep disorders are associated with pre-school ADHD symptoms.Methods.The study included 3634 singletons from the Italian NINFEA (Nascita e INFanzia: gli Effetti dell'Ambiente’) cohort. Maternal doctor-diagnosed anxiety, depression and sleep disorders before and during pregnancy were assessed from the questionnaires completed during pregnancy and 6 months after delivery. Mothers rated child ADHD symptoms at 4 years of age, according to the Diagnostic and Statistical Manual of Mental Disorders. Hyperactive–impulsive (ADHD-H), inattentive (ADHD-I) and total ADHD scores were analysed in the models adjusted for child's gender, first-born status, maternal age, education, alcohol consumption and smoking during pregnancy.Results.The total ADHD score at age 4 was associated with maternal lifetime anxiety (17.1% percentage difference in score compared with never; 95% CI 7.3–27.9%), sleep disorders (35.7%; 95% CI 10.7–66.5%) and depression (17.5%; 95% CI 3.2–33.8%). Similar positive associations were observed also for ADHD-H and ADHD-I traits, with slightly attenuated associations between maternal sleep disorders and child ADHD-I score, and maternal depression and both ADHD scores. All the estimates were enhanced when the disorders were active during pregnancy and attenuated for disorders active only during the pre-pregnancy period.Conclusions.Maternal anxiety, depression and sleep disorders are associated with a relative increase in the number of ADHD-H, ADHD-I and total ADHD symptoms in preschoolers.
Rapid Changes in Anthropogenic Carbon Storage and Ocean Acidification in the Intermediate Layers of the Eurasian Arctic Ocean: 1996–2015
Authors: Ulfsbo Adam , Jones Elizabeth M. , Casacuberta Núria , Korhonen Meri , Rabe Benjamin , Karcher Michael , van Heuven Steven M.A.C. 
Published: April 2018

The extended multiple linear regression technique is used to determine changes in anthropogenic carbon in the intermediate layers of the Eurasian Basin based on occupations from four cruises between 1996 and 2015. The results show a significant increase in basin‐wide anthropogenic carbon storage in the Nansen Basin (0.44–0.73 ± 0.14 mol C·m−2·year−1) and the Amundsen Basin (0.63–1.04 ± 0.09 mol C·m−2·year−1). Over the last two decades, inferred changes in ocean acidification (0.020–0.055 pH units) and calcium carbonate desaturation (0.05–0.18 units) are pronounced and rapid. These results, together with results from carbonate‐dynamic box model simulations and 129I tracer distribution simulations, suggest that the accumulation of anthropogenic carbon in the intermediate layers of the Eurasian Basin are consistent with increasing concentrations of anthropogenic carbon in source waters of Atlantic origin entering the Arctic Ocean followed by interior transport. The dissimilar distributions of anthropogenic carbon in the interior Nansen and Amundsen Basins are likely due to differences in the lateral ventilation of the intermediate layers by the return flows and ramifications of the boundary current along the topographic boundaries in the Eurasian Basin.
Automated Large‐Scale Full Seismic Waveform Inversion for North America and the North Atlantic
Authors: Krischer Lion , Fichtner Andreas , Boehm Christian , Igel Heiner 
Published: April 2018

AbstractWe present a new anisotropic seismic tomography model based on a multiscale full seismic waveform inversion for crustal and upper‐mantle structure from the western edge of North America across the North Atlantic and into Europe. The gradient‐based inversion strategy utilizes the adjoint state method coupled with an L‐BFGS quasi‐Newton optimization scheme. To improve the handling of large data quantities in the context of full seismic waveform inversions, we developed a workflow framework automating the procedure across all stages, enabling us to confidently invert for waveforms from 72 events recorded at 7,737 unique stations, resulting in a total of 144,693 raypaths, most of them with three‐component recordings. The final model after 20 iterations is able to explain complete waveforms including body as well as surface waves of earthquakes that were not used in the inversion down to periods of around 30 s. The model is complemented by a detailed resolution analysis in the form of 3‐D distributions of direction‐dependent resolution lengths.
Geological Evolution of Titan's Equatorial Regions: Possible Nature and Origin of the Dune Material
Authors: Brossier J. F. , Rodriguez S. , Cornet T. , Lucas A. , Radebaugh J. , Maltagliati L. , Le Mouélic S. , Solomonidou A. , Coustenis A. , Hirtzig M. , Jaumann R. , Stephan K. , Sotin C. 
Published: April 2018

AbstractIn 13 years, infrared observations from the Visual and Infrared Mapping Spectrometer onboard Cassini provided significant hints about the spectral and geological diversity of Titan's surface. The analysis of the infrared (IR) signature of spectral units enables constraining the surface composition, which is crucial for understanding possible interactions between Titan's interior, surface, and atmosphere. Here we investigate a selection of areas in the equatorial regions, imaged by Cassini's instruments, which exhibit an apparent transition from the Visual and Infrared Mapping Spectrometer IR‐bright to the IR‐blue and IR‐brown units (from false‐color composites using red: 1.57/1.27 μm, green: 2.01/1.27 μm, and blue: 1.27/1.08 μm). By applying an updated radiative transfer model, we extract the surface albedo of IR units identified in these regions. Then, we compare them with synthetic mixtures of two expected components on Titan's surface, namely, water ice and laboratory tholins. This allows us to reconnect the derived composition and grain size information to the geomorphology observed from Radio Detection and Ranging instrument (RADAR)/Synthetic Aperture Radar images. We interpret IR‐bright units as hills and plains coated by organic material and incised by fluvial networks. Erosion products are transported downstream to areas where IR‐blue units are seen near the IR‐bright units. These units, enriched in water ice, are most likely outwash plains hosting debris from fluvial erosion. Farther away from the IR‐bright units, the IR‐brown units are dominantly made of organics with varied grain sizes, ranging from dust‐ to sand‐sized particles that form the dune fields. The transition areas therefore exhibit trends in water ice content and grain size supported by geomorphological observations.
Useful pharmacodynamic endpoints in children: selection, measurement, and next steps
Authors: Kelly Lauren E , Sinha Yashwant , Barker Charlotte I S , Standing Joseph F , Offringa Martin 
Published: April 2018

Abstract
Pharmacodynamic (PD) endpoints are essential for establishing the benefit-to-risk ratio for therapeutic interventions in children and neonates. This article discusses the selection of an appropriate measure of response, the PD endpoint, which is a critical methodological step in designing pediatric efficacy and safety studies. We provide an overview of existing guidance on the choice of PD endpoints in pediatric clinical research. We identified several considerations relevant to the selection and measurement of PD endpoints in pediatric clinical trials, including the use of biomarkers, modeling, compliance, scoring systems, and validated measurement tools. To be useful, PD endpoints in children need to be clinically relevant, responsive to both treatment and/or disease progression, reproducible, and reliable. In most pediatric disease areas, this requires significant validation efforts. We propose a minimal set of criteria for useful PD endpoint selection and measurement. We conclude that, given the current heterogeneity of pediatric PD endpoint definitions and measurements, both across and within defined disease areas, there is an acute need for internationally agreed, validated, and condition-specific pediatric PD endpoints that consider the needs of all stakeholders, including healthcare providers, policy makers, patients, and families.
A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling
Authors: Salomé Mara , Magee Aoife , Yalla Krisha , Chaudhury Shahzya , Sarrou Evgenia , Carmody Ruaidhrí J , Keeshan Karen 
Published: April 2018

AbstractTrib2 pseudokinase is involved in the etiology of a number of cancers including leukaemia, melanoma, ovarian, lung and liver cancer. Both high and low Trib2 expression levels correlate with different types of cancer. Elevated Trib2 expression has oncogenic properties in both leukaemia and lung cancer dependent on interactions with proteasome machinery proteins and degradation of transcription factors. Here, we demonstrated that Trib2 deficiency conferred a growth and survival advantage both at steady state and in stress conditions in leukaemia cells. In response to stress, wild type leukaemia cells exited the cell cycle and underwent apoptosis. In contrast, Trib2 deficient leukaemia cells continued to enter mitosis and survive. We showed that Trib2 deficient leukaemia cells had defective MAPK p38 signalling, which associated with a reduced γ-H2Ax and Chk1 stress signalling response, and continued proliferation following stress, associated with inefficient activation of cell cycle inhibitors p21, p16 and p19. Furthermore, Trib2 deficient leukaemia cells were more resistant to chemotherapy than wild type leukaemia cells, having less apoptosis and continued propagation. Trib2 re-expression or pharmacological activation of p38 in Trib2 deficient leukaemia cells sensitised the cells to chemotherapy-induced apoptosis comparable with wild type leukaemia cells. Our data provide evidence for a tumour suppressor role of Trib2 in myeloid leukaemia via activation of p38 stress signalling. This newly identified role indicates that Trib2 may counteract the propagation and chemotherapy resistance of leukaemia cells.
Inhibition of cyclin-dependent kinase 4 as a potential therapeutic strategy for treatment of synovial sarcoma
Authors: Li Xiaoyang , Seebacher Nicole A. , Garbutt Cassandra , Ma Hangzhan , Gao Peng , Xiao Tao , Hornicek Francis J. , Duan Zhenfeng 
Published: April 2018

AbstractSynovial sarcoma is a highly aggressive but rare form of soft tissue malignancy that primarily affects the extremities of the arms or legs, for which current chemotherapeutic agents have not been proven to be very effective. The cyclin-dependent kinase 4/6-retinoblastoma protein (CDK4/6-Rb) pathway of cell cycle control is known to be aberrant in a large proportion of cancers. Recently, CDK4 inhibitors have successfully been used pre-clinically for the treatment of many human cancers, and in 2015, following the success of clinical trials, the FDA approved the first selective CDK4/6 inhibitor, palbociclib, for the treatment of endocrine therapy resistant breast cancers. However, the expression and therapeutic potential of targeting CDK4 in synovial sarcoma remains unclear. In the present study, we report that CDK4 is highly expressed in human synovial sarcoma, and high CDK4 expressions are associated with poor prognosis in sarcomas patients and the clinical stage and the TNM grade in synovial sarcoma patients. Knockdown of CDK4 with specific small interference RNAs inhibits cell proliferation and enhances apoptotic effects in synovial sarcoma cells. CDK4 inhibitor palbociclib suppresses synovial sarcoma cell proliferation and growth in a dose and time-dependent manner. Palbociclib also inhibits the CDK4/6-Rb signaling pathway and promotes cell apoptosis without changing CDK4/6 protein levels, suggesting that palbociclib only represses the hyper-activation, not the expression of CDK4/6. Flow cytometry analysis reveals that palbociclib induces G1 cell-cycle arrest and apoptotic effects by targeting the CDK4/6-Rb pathway in synovial sarcoma cells. Furthermore, wound healing assays demonstrate that inhibition of the CDK4/6-Rb pathway by palbociclib significantly decreases synovial sarcoma cell migration in vitro. Our study highlights the importance of the CDK4/6-Rb pathway in human synovial sarcoma pathogenesis, and the role of the current selective CDK4/6 inhibitor, palbociclib, as a potential promising targeted therapeutic agent in the treatment of human synovial sarcoma.
Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex
Authors: Coulson Rochelle L. , Yasui Dag H. , Dunaway Keith W. , Laufer Benjamin I. , Vogel Ciernia Annie , Zhu Yihui , Mordaunt Charles E. , Totah Theresa S. , LaSalle Janine M. 
Published: April 2018

AbstractRhythmic oscillations of physiological processes depend on integrating the circadian clock and diurnal environment. DNA methylation is epigenetically responsive to daily rhythms, as a subset of CpG dinucleotides in brain exhibit diurnal rhythmic methylation. Here, we show a major genetic effect on rhythmic methylation in a mouse Snord116 deletion model of the imprinted disorder Prader–Willi syndrome (PWS). More than 23,000 diurnally rhythmic CpGs are identified in wild-type cortex, with nearly all lost or phase-shifted in PWS. Circadian dysregulation of a second imprinted Snord cluster at the Temple/Kagami-Ogata syndrome locus is observed at the level of methylation, transcription, and chromatin, providing mechanistic evidence of cross-talk. Genes identified by diurnal epigenetic changes in PWS mice overlapped rhythmic and PWS-specific genes in human brain and are enriched for PWS-relevant phenotypes and pathways. These results support the proposed evolutionary relationship between imprinting and sleep, and suggest possible chronotherapy in the treatment of PWS and related disorders.
Structural basis for the activation of acid ceramidase
Authors: Gebai Ahmad , Gorelik Alexei , Li Zixian , Illes Katalin , Nagar Bhushan 
Published: April 2018

AbstractAcid ceramidase (aCDase, ASAH1) hydrolyzes lysosomal membrane ceramide into sphingosine, the backbone of all sphingolipids, to regulate many cellular processes. Abnormal function of aCDase leads to Farber disease, spinal muscular atrophy with progressive myoclonic epilepsy, and is associated with Alzheimer’s, diabetes, and cancer. Here, we present crystal structures of mammalian aCDases in both proenzyme and autocleaved forms. In the proenzyme, the catalytic center is buried and protected from solvent. Autocleavage triggers a conformational change exposing a hydrophobic channel leading to the active site. Substrate modeling suggests distinct catalytic mechanisms for substrate hydrolysis versus autocleavage. A hydrophobic surface surrounding the substrate binding channel appears to be a site of membrane attachment where the enzyme accepts substrates facilitated by the accessory protein, saposin-D. Structural mapping of disease mutations reveals that most would destabilize the protein fold. These results will inform the rational design of aCDase inhibitors and recombinant aCDase for disease therapeutics.