bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microwave irradiation directly excites semiconductor catalyst to produce electric current or electron-holes pairs
Authors: Zhou Jicheng , You Zhimin , Xu Wentao , Su Zhiming , Qiu Yin , Gao Lingfei , Yin Cheng , Lan Lixin 
Published: April 2019

AbstractGenerally, photon of Microwave (MW) electromagnetic waves have long been thought to be lower energy, which could not excite metals or semiconductor materials to generate electric current and electron-holes pairs (e−cb + h+vb). In this paper, we report an unexpected, Microwave “photoelectric effect”, when MW irradiates on the semiconductor materials, leading to generate electric current and electron-holes pairs (e−cb + h+vb), on the semiconductor materials and on the MW catalyst. Further, we show that the action mechanism of Microwave “photoelectric effect” made water adsorbing on the surface of Microwave catalyst transform into hydroxyl radical (∙OH). Thus, this study has revealed the principle of generation Microwave “photoelectric effect” under MW irradiation, and the mechanism of MW catalytic oxidation degradation of organic in the wastewater and the mechanism of MW reduction method for preparation of nano-particle metal supported catalysts. Our findings challenge the classic view of MW irradiation only as heating method, which cannot excite to produce electric current and electron-holes pairs (e−cb + h+vb). Our findings will open new field to use MW technology for MW catalytic oxidation degradation of organics in the wastewater, and for MW reduction method of metal supported catalysts preparation.
Continuous but not intermittent noise has a negative impact on mating success in a marine fish with paternal care
Authors: Blom Eva-Lotta , Kvarnemo Charlotta , Dekhla Isabelle , Schöld Sofie , Andersson Mathias H. , Svensson Ola , Amorim M. Clara. P. 
Published: April 2019

AbstractAnthropogenic underwater noise is a global pollutant of increasing concern but its impact on reproduction in fish is largely unknown. Hence, a better understanding of its consequences for this important link to fitness is crucial. Working in aquaria, we experimentally tested the impact of broadband noise exposure (added either continuously or intermittently), compared to a control, on the behaviour and reproductive success of the common goby (Pomatoschistus microps), a vocal fish with exclusive paternal care. Compared to the intermittent noise and control treatments, the continuous noise treatment increased latency to female nest inspection and spawning and decreased spawning probability. In contrast, many other female and male pre-spawning behaviours, and female ventilation rate (proxies for stress levels) did not differ among treatments. Therefore, it is likely that female spawning decisions were delayed by a reduced ability to assess male acoustic signals, rather than due to stress per se and that the silent periods in the intermittent noise treatment provided a respite where the females could assess the males. Taken together, we show that noise (of similar frequency range as anthropogenic boat noise) negatively affects reproductive success, particularly under a continuous noise exposure.
Meta-path Based Prioritization of Functional Drug Actions with Multi-Level Biological Networks
Authors: Yoon Seyeol , Lee Doheon 
Published: April 2019

AbstractFunctional drug actions refer to drug-affected GO terms. They aid in the investigation of drug effects that are therapeutic or adverse. Previous studies have utilized the linkage information between drugs and functions in molecular level biological networks. Since the current knowledge of molecular level mechanisms of biological functions is still limited, such previous studies were incomplete. We expected that the multi-level biological networks would allow us to more completely investigate the functional drug actions. We constructed multi-level biological networks with genes, GO terms, and diseases. Meta-paths were utilized to extract the features of each GO term. We trained 39 SVM models to prioritize the functional drug actions of the various 39 drugs. Through the multi-level networks, more functional drug actions were utilized for the 39 models and inferred by the models. Multi-level based features improved the performance of the models, and the average AUROC value in the cross-validation was 0.86. Moreover, 60% of the candidates were true.
Lytic and genomic properties of spontaneous host-range Kayvirus mutants prove their suitability for upgrading phage therapeutics against staphylococci
Authors: Botka Tibor , Pantůček Roman , Mašlaňová Ivana , Benešík Martin , Petráš Petr , Růžičková Vladislava , Havlíčková Pavla , Varga Marian , Žemličková Helena , Koláčková Ivana , Florianová Martina , Jakubů Vladislav , Karpíšková Renáta , Doškař Jiří 
Published: April 2019

AbstractLytic bacteriophages are valuable therapeutic agents against bacterial infections. There is continual effort to obtain new phages to increase the effectivity of phage preparations against emerging phage-resistant strains. Here we described the genomic diversity of spontaneous host-range mutants of kayvirus 812. Five mutant phages were isolated as rare plaques on phage-resistant Staphylococcus aureus strains. The host range of phage 812-derived mutants was 42% higher than the wild type, determined on a set of 186 methicillin-resistant S. aureus strains representing the globally circulating human and livestock-associated clones. Comparative genomics revealed that single-nucleotide polymorphisms from the parental phage 812 population were fixed in next-step mutants, mostly in genes for tail and baseplate components, and the acquired point mutations led to diverse receptor binding proteins in the phage mutants. Numerous genome changes associated with rearrangements between direct repeat motifs or intron loss were found. Alterations occurred in host-takeover and terminal genomic regions or the endolysin gene of mutants that exhibited the highest lytic activity, which implied various mechanisms of overcoming bacterial resistance. The genomic data revealed that Kayvirus spontaneous mutants are free from undesirable genes and their lytic properties proved their suitability for rapidly updating phage therapeutics.
MOMSense: Metal-Oxide-Metal Elementary Glucose Sensor
Authors: Abunahla Heba , Mohammad Baker , Alazzam Anas , Jaoude Maguy Abi , Al-Qutayri Mahmoud , Abdul Hadi Sabina , Al-Sarawi Said F. 
Published: April 2019

AbstractIn this paper, we present a novel Pt/CuO/Pt metal-oxide-metal (MOM) glucose sensor. The devices are fabricated using a simple, low-cost standard photolithography process. The unique planar structure of the device provides a large electrochemically active surface area, which acts as a nonenzymatic reservoir for glucose oxidation. The sensor has a linear sensing range between 2.2 mM and 10 mM of glucose concentration, which covers the blood glucose levels for an adult human. The distinguishing property of this sensor is its ability to measure glucose at neutral pH conditions (i.e. pH = 7). Furthermore, the dilution step commonly needed for CuO-based nonenzymatic electrochemical sensors to achieve an alkaline medium, which is essential to perform redox reactions in the absence of glucose oxidase, is eliminated, resulting in a lower-cost and more compact device.
On the influence of relative humidity on the oxidation and hydrolysis of fresh and aged oil paints
Authors: Modugno Francesca , Di Gianvincenzo Fabiana , Degano Ilaria , van der Werf Inez Dorothé , Bonaduce Ilaria , van den Berg Klaas Jan 
Published: April 2019

AbstractModern oil paintings are affected by conservation issues related to the oil paint formulations and to the fact that they are often unvarnished, and in direct contact with the environment. Understanding the evolution of the molecular composition of modern oil paint during ageing, under the influence of environmental factors, is fundamental for a better knowledge of degradation phenomena and risk factors affecting modern art. We investigated for the first time the influence of relative humidity on the chemical composition of modern oil paints during curing and artificial ageing. For this purpose, modern oil paint layers naturally aged for 10 years were further artificially aged in low and high relative humidity conditions. Moreover, the influence of RH% on the curing of fresh paint layers was studied. The paints used in the experiments are from three suppliers (Old Holland, Winsor&Newton, and Talens), and contain cadmium or cadmium zinc sulfide as main pigment. The changes in the composition of extracts of paint samples were investigated by direct electrospray mass spectrometry with a quadrupole-time of flight mass analyser (ESI-Q-ToF). The obtained mass spectral data were interpreted by means of principal component analysis (PCA) operated on a data set containing the relative abundance of ions associated to significant molecules present in the extracts, and also by calculating the ratios between the signals relative to fatty acids, dicarboxylic acids and acylglycerols, related to hydrolysis and oxidation phenomena. The same paint samples were also analysed, in bulk, by pyrolysis gas chromatography mass spectrometry (Py-GC/MS), achieving chemical information on the total lipid fraction. High performance liquid chromatography (HPLC) ESI-Q-ToF was carried out for the characterisation of the profile of free fatty acids (FFA) and acylglycerols, defining the nature of the oils used in the paint formulations, and for the determination of the degree of hydrolysis. This study demonstrated that relative humidity conditions significantly influence the chemical composition of the paints. Ageing under high RH% conditions produced an increase of the formation of dicarboxylic acids compared to ageing under low RH%, for all paints, in addition to a higher degree of hydrolysis, followed by evaporation of free fatty acids.
Regional gender differences in an autosomal disease result in corresponding diversity differences
Authors: Guan Shenmin , Zhao Yingying , Zhuo Xiao , Song Wenhui , Geng Xiaorui , Yang Huanming , Wang Jian , Wu Xinhua , Yang Jinlong , Song Xin , Cheng Le 
Published: April 2019

AbstractRegional gender differences in autosomal chromosome disorders have been observed repeatedly. However, the corresponding diversity changes remain unconfirmed. By analyzing previously published thalassemia data from the Dai people in Dehong and Xishuangbanna (two regions in Yunnan Province, China), we found that several sequence types, including HBA CNV and HBB mutations, significantly depend on gender in Xishuangbanna but not in Dehong. With the supportive evidence from previous researches, we accept that some certain mutations depend on gender regionally. This association seems peculiar. It is among one common people on a small geographical scale, while other recorded thalassemia gender difference varies by ethnics and continent.
Flexible, transparent patterned electrodes based on graphene oxide/silver nanowire nanocomposites fabricated utilizing an accelerated ultraviolet/ozone process to control silver nanowire degradation
Authors: Choo Dong Chul , Bae Sang Kyung , Kim Tae Whan 
Published: April 2019

AbstractWe developed flexible, transparent patterned electrodes, which were fabricated utilizing accelerated ultraviolet/ozone (UV/O3)-treated graphene oxide (GO)/silver nanowire (Ag-NW) nanocomposites via a simple, low-cost pattern process to investigate the feasibility of promising applications in flexible/wearable electronic and optoelectronic devices. The UV/O3 process of the GO/Ag-NW electrode was accelerated by the pre-heat treatment, and the degradation interruption of Ag NWs was removed by the GO treatment. After the deposition of the GO-treated Ag NW electrodes, the sheet resistance of the thermally annealed GO-treated Ag-NW electrodes was significantly increased by using the UV/O3 treatment, resulting in a deterioration of the GO-treated Ag NWs in areas exposed to the UV/O3 treatment. The degradation of the Ag NWs caused by the UV/O3 treatment was confirmed by using the sheet resistances, scanning electron microscopy images, X-ray photoelectron microscopy spectra, and transmittance spectra. While the sheet resistance of the low-density Ag-NW electrode was considerably increased due to the pre-thermal treatment at 90 °C for 10 min, that of the high-density Ag-NW electrode did not vary significantly even after a UV/O3 treatment for a long time. The degradation interference phenomenon caused by the UV/O3 treatment in the high-density Ag NWs could be removed by using a GO treatment, which resulted in the formation of a Ag-NW electrode pattern suitable for promising applications in flexible organic light-emitting devices. The GO treatment decreased the sheet resistance of the Ag-NW electrode and enabled the pattern to be formed by using the UV/O3 treatment. The selective degradation of Ag NWs due to UV/O3 treatment decreased the transparency of the Ag-NW electrode by about 8% and significantly increased its sheet resistance more than 100 times.
Somatosensory-guided tool use modifies arm representation for action
Authors: Martel M. , Cardinali L. , Bertonati G. , Jouffrais C. , Finos L. , Farnè A. , Roy A. C. 
Published: April 2019

AbstractTool-use changes both peripersonal space and body representations, with several effects being nowadays termed tool embodiment. Since somatosensation was typically accompanied by vision in most previous tool use studies, whether somatosensation alone is sufficient for tool embodiment remains unknown. Here we address this question via a task assessing arm length representation at an implicit level. Namely, we compared movement’s kinematics in blindfolded healthy participants when grasping an object before and after tool-use. Results showed longer latencies and smaller peaks in the arm transport component after tool-use, consistent with an increased length of arm representation. No changes were found in the hand grip component and correlations revealed similar kinematic signatures in naturally long-armed participants. Kinematics changes did not interact with target object position, further corroborating the finding that somatosensory-guided tool use may increase the represented size of the participants’ arm. Control experiments ruled out alternative interpretations based upon altered hand position sense. In addition, our findings indicate that tool-use effects are specific for the implicit level of arm representation, as no effect was observed on the explicit estimate of the forearm length. These findings demonstrate for the first time that somatosensation is sufficient for incorporating a tool that has never been seen, nor used before.
Uranium-rich diagenetic fluids provide the key to unconformity-related uranium mineralization in the Athabasca Basin
Authors: Chi Guoxiang , Chu Haixia , Petts Duane , Potter Eric , Jackson Simon , Williams-Jones Anthony 
Published: April 2019

AbstractThe Proterozoic Athabasca Basin is well known for its unusually large-tonnage and high-grade ‘unconformity-related’ uranium (U) deposits, however, explanations for the basin-wide U endowment have not been clearly identified. Previous studies indicate that U-rich brines with up to ~600 ppm U and variable Na/Ca ratios (from Na-dominated to Ca-dominated) were present at the sites of U mineralization, but it is unknown whether such fluids were developed solely in the vicinity of the U deposits or at a basinal scale. Our microthermometric and LA-ICP-MS analyses of fluid inclusions in quartz overgrowths from the barren part of the basin indicate that U-rich brines (0.6 to 26.8 ppm U), including Na-dominated and Ca-dominated varieties, were widely developed in the basin. These U concentrations, although not as high as the highest found in the U deposits, are more than two orders of magnitude higher than most naturally occurring geologic fluids. The basin-scale development of U-rich diagenetic fluids is interpreted to be related to several geologic factors, including availability of basinal brines and U-rich lithologies, and a hydrogeologic framework that facilitated fluid circulation and U leaching. The combination of these favorable conditions is responsible for the U fertility of the Athabasca Basin.
Frequency analysis and representation of slowly diffusing planetary solutions
Authors: Fu Y. N. , Laskar J. 
Published: April 2019

Context. Over short time-intervals, planetary ephemerides have traditionally been represented in analytical form as finite sums of periodic terms or sums of Poisson terms that are periodic terms with polynomial amplitudes. This representation is not well adapted for the evolution of planetary orbits in the solar system over million of years which present drifts in their main frequencies as a result of the chaotic nature of their dynamics.
Aims. We aim to develop a numerical algorithm for slowly diffusing solutions of a perturbed integrable Hamiltonian system that will apply for the representation of chaotic planetary motions with varying frequencies.
Methods. By simple analytical considerations, we first argue that it is possible to exactly recover a single varying frequency. Then, a function basis involving time-dependent fundamental frequencies is formulated in a semi-analytical way. Finally, starting from a numerical solution, a recursive algorithm is used to numerically decompose the solution into the significant elements of the function basis.
Results. Simple examples show that this algorithm can be used to give compact representations of different types of slowly diffusing solutions. As a test example, we show that this algorithm can be successfully applied to obtain a very compact approximation of the La2004 solution of the orbital motion of the Earth over 40 Myr ([−35 Myr, 5 Myr]). This example was chosen because this solution is widely used in the reconstruction of the past climates.
Pankreaskarzinom 2018 – reif für personalisierte Therapiekonzepte?
Authors: Simon Ole , Beyer Georg , Mahajan Ujjwal , Mayerle Julia 
Published: April 2019

Zusammenfassung
Epidemiologie Die 5-Jahres-Überlebensrate (5-JÜR) aller Pankreaskarzinompatienten liegt mit rund 6 % sehr niedrig und die potenziell kurative Operation ist nur bei 15 – 20 % der Erkrankten möglich. Durch häufigeren Einsatz und Kombination systemischer Chemotherapeutika konnte in den letzten Jahren eine verbesserte Lebenserwartung erreicht werden.
Resektables Stadium Nach vollständiger operativer Resektion eines Pankreaskarzinoms trägt eine adjuvante Chemotherapie zur Verlängerung des Gesamtüberlebens bei. Mittel der Wahl sind Gemcitabin oder 5-Fluorouracil (5-FU) und Folinsäure (FS). Kürzlich konnte für die Kombination aus Gemcitabin und Capecitabin (Gem-Cap) eine signifikante Verlängerung des Gesamtüberlebens im Vergleich zur Gemcitabin-Monotherapie gezeigt werden. Für den Einsatz einer adjuvanten Radiochemotherapie gibt es derzeit keine Empfehlung.
Borderline-resektables Stadium Eine neoadjuvante Therapie hat bei Pankreaskarzinomen außerhalb klinischer Studien keinen Stellenwert. Eine Ausnahme stellen borderline-resektable Pankreaskarzinome dar.
Fortgeschrittenes Stadium (M1) Patienten mit fortgeschrittenem oder metastasiertem Pankreaskarzinom profitieren von einer Chemotherapie. Für Patienten mit gutem ECOG-Status konnte kürzlich in 2 Phase-III-Studien eine signifikante Lebenszeitverlängerung durch die Kombination aus Gemcitabin plus nab-Paclitaxel (Gem-Nab) sowie durch das Kombinationsschema aus Folinsäure, 5-FU, Irinotecan und Oxaliplatin (FOLFIRINOX) gezeigt werden. In der Zweitlinie steht nanoliposomales Irinotecan oder Oxaliplatin kombiniert mit 5FU/FS (OFF) zur Verfügung.
Personalisierte Therapien Die molekulare Charakterisierung des Pankreaskarzinoms hat Fortschritte gemacht und bietet schon heute Ansätze zur personalisierten Medizin. Bei gutem ECOG-Status sollte vor Zweitlinientherapie eine MSI-H/dMMR-Analyse erfolgen, um den möglichen Einsatz einer Checkpoint-Inhibitor-Therapie zu evaluieren. Bei BRCA-Mutationen kann die Gabe von PARP-Inhibitoren vielversprechend sein.
Treating the Lips and Its Anatomical Correlate in Respect to Vascular Compromise
Authors: Ghannam Sahar , Sattler Sonja , Frank Konstantin , Freytag David , Webb Katherine , Devineni Aditya , Cotofana Sebastian 
Published: April 2019

AbstractTreating the lips to increase facial attractiveness and youthfulness is challenging when trying to consider ethnic differences in an increasingly more diverse society. Multiple injection techniques are currently available for treating lip contour and volume, but a validation in the cadaveric model under the aspects of safety has not been performed yet. The injection techniques presented in this study are based on the experience and personal selection of the authors. The authors have assessed, treated, and evaluated for more than 20 years patients from the Middle East and Central Europe. Cadaveric verification was performed for each of the presented techniques to identify the positioning of the injected product inside the lips and its relation to the superior/inferior labial arteries. The results of the anatomic analyses revealed that in 58.3% of the performed injections, the product was placed close to the superior/inferior labial arteries. In 60.0% of the cases, applications using a needle placed the injected product in endangered locations, whereas 57.1% of the cases using cannulas placed the product in endangered locations (i.e., in the vicinity of the superior/inferior labial arteries). This anatomic study revealed that injected material into the lips is frequently placed in close proximity to labial arteries representing a high risk for intra-arterial applications, leading to tissue loss (necrosis) and potential end-arterial embolism (potential blindness). Nevertheless, treatment of the lips should be a multistep approach focusing first on the far (upper and middle face) and close (labiomandibular and labiomental) perioral regions.
Decreasing Incidence of Postoperative Ileus Following Total Hip Arthroplasty: A 17-Year Retrospective Review of 31,619 Total Hip Replacements at One Institution
Authors: Nguyen Bob , Bono Olivia J. , Bono James V. 
Published: April 2019

AbstractIleus following total hip arthroplasty (THA) is a clinically and financially significant postoperative complication that has not been extensively described in the orthopaedic joint literature. Ileus has been found to occur in 0.7 to 4.0% of patients after total joint arthroplasty and as high as 5.6% in patients after revision THA.1,2,3 In a 17-year period (2001 Fiscal Year through 2017 Fiscal Year) at one institution, the authors found an incidence of 0.674% (213/31619) following THA. In addition, the incidence of ileus following THA has drastically declined over this 17-year period, from 1.822% (19/1043) in 2001 to 0.099% (3/3036) in 2017. This decrease may be attributed to a reduction in narcotic use postoperatively, earlier ambulation following surgery, and reduction in length of hospital stay. Though postoperative ileus is not yet a preventable complication, recognition of risk factors may permit earlier intervention to ameliorate some of the morbidity associated with this condition.