bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, physico-chemical properties of 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetohyd-razides
Authors: Safonov A. A. 
Published: March 2019

The value of the class of 1,2,4-triazole derivatives to create a low-toxic and highly active substances is huge. There are a lot of facts about the high biological activity among a number of substances. The 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazides derivatives causes of particular interest in this direction.
The aim of the work was to synthesize 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazides and their derivatives, studying of their physico-chemical properties.
2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)-N'-R-acetohydrazides were synthesized by of 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazides with aldehydes and ketones in the i-propanol with the addition of hydrochloric acid.
The melting point was determined by an automatic device for determining the melting point OptiMelt Stanford Research Systems MPA100 (US). The elemental composition of compounds found in elemental analyzer Elementar Vario L cube (CHNS) (standard ‒ sulfonamides). Chromatography-mass spectral studies conducted on gas-liquid chromatograph Agilent 1260 Infinity HPLC with equipped mass spectrometer Agilent 6120, 1H-NMR-spectra were registered on spectrometer Mercury 400
A series of new 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)-N'-R-acetohydrazides derivatives were synthesized, R-2-chloro-6-fluorobenzylidene, 3-nitrobenzylidene, 4-hydroxybenzylidene, 2-nitrobenzylidene, 2,4-dimethylbenzylidene, 3,5-dimethoxybenzylidene, 3-bromo-4-fluorobenzylidene, 2,3-dimethoxybenzylidene, 2-bromobenzylidene, 2-fluorobenzylidene, 4-(dimethylamino)benzylidene, pyridin-2-ylmethylene, 5-nitrofuran-2-ylmethylene, 4-methoxybenzylidene, 2-hydroxybenzylidene, 4-methoxyphenyl)ethylidene, 1-(thiophen-2-yl)ethylidene. The structure of these compounds was established by modern physico-chemical analysis methods (elemental analysis, 1H-NMR spectroscopy). Individuality was proved by HPLC-MS.
Histological study of the influence of antidiabetic plant collection on pancreatic tissue in rats with diabetes mellitus, which is induced by dexamethasone
Authors: Savych A. O. , Marchyshyn S. M. , Ostrovsky N. M. , Laryanovska Y. B. 
Published: March 2019

Diabetes mellitus is a global problem today, because there is a sharp increase the number of patients in the world each year. Severe complications of diabetes are very dangerous because it can lead to disability of patients and high mortality.
The aim of our work was to study the protective effect of antidiabetic plant collection on the pancreas in rats with diabetes type 2, caused by the introduction of dexamethasone.
The research materials were pancreatic tissue of rats with experimental diabetes that received the decoction (1:10) of antidiabetic plant collection (witch includes Equiseti arvensis herba, Sambuci flores, Inulae rhizomata et radices, Hyperici herba, Tiliae flores, Polygoni avicularis herba, Myrtilli folium, Urticae folia) in treatment and preventive mode. The model of diabetes mellitus was induced by administration of dexamethasone 0.125 ml/kg for 15 days.
Decoction of antidiabetic plant collection in doses 6 ml/kg, 9 ml/kg and 12 ml/kg reduces diabetogenic properties of dexamethasone when administered simultaneously. The insular tissue increases absorbance pancreatic islets, to some extent restored the normal percentage distribution of the islets in size, histologically visualized the increase more high-grade cells.
The study found that antidiabetic plant collection reduces destructive-dystrophic changes of insular apparatus in rats with diabetes type 2. Antidiabetic effect of the studied plant collection has dose-dependent nature. The most effective conditional-effective doses are 9 and 12 ml/kg.
Development of school biological education in Ukraine: retrospective and present
Authors: Novykova Nina 
Published: March 2019

The necessity of introducing a new paradigm of educational and pedagogical activity in Ukraine is outlined: the accumulation of a large number of factual data in the natural sciences required new general-scientific logic-methodological approaches, which includes a systematic (system-structural) approach, therefore it is important to study the components (elements) of the system and their interaction. The system vision of wildlife has confirmed the universality, the importance of all levels of organization of the living: molecular genetic, cellular, organism (ontogenetic), populational-species, biogeocoenic-biosphere.
The methodology of the study of school biological education in the aspect of orientation of the European direction of educational development, in particular the use of synergetic, systemic-structural and holistic approaches, is considered. The methodology of pedagogy includes principles and methods of cognition in pedagogical theory and practice During the time of Ukraine's independence, the target orientation of education, its didactic support, and new methodological principles have been transformed. in the conduct of research it is necessary to consider in the relationship of philosophical methodology, psychological and pedagogical methodology and specific methodology (methodology of the topic under study).
The study of the development of school biological education as a holistic pedagogical system involves its multicomponent (target, content, procedural, gnostic-professional and analytical-productive) with new methodological approaches to its study. The school system of education should ensure the full mastery of the students of the foundations of science, the formation of a scientific picture of the world, an understanding of the need for a careful attitude to nature, man and the values that she created, skills and abilities to act in non-standard situations. The solution of these tasks is aimed at further improving the content of school education, the search for new technologies that would improve the efficiency of the educational process. The essence of levels of scientific knowledge is revealed; the holistic model of school biological education as the basis for its periodization in Ukraine during the XX - the beginning of the XXI century was proposed. The peculiarities of changes on each of the four periods and corresponding stages of the system of school biological education in the socio-economic, scientific-pedagogical and methodical aspects are analyzed. The general tendencies of school biology are revealed.
Pengaruh Lokasi dan Kualitas Pelayanan Terhadap Kepuasan Pelanggan Pada Jasa Pengiriman J & T di Muara Bulian
Authors: Mukhlis M Aziz 
Published: March 2019

Bussiness world competition currently is more progressively tight. It is also perceived by services J & T In muara bulian. J & T is demanded to understand about the factors that can influence their customer’s satisfaction. J & T have to make some improvement and innovation that can increasing their customer’s satisfaction. The research aims to analyze how the influence of service quality, and location toward customer satisfaction. Sample of the research is 81 customer and then an analysis is performed toward the obtained data by using data analysis quantitatively and qualitatively. Quantitatively analysis includes: validity and realibility test, classical assumption test, multiple regression analysis and hypothesis test through t and F test, and determination coefficient analysis (R²). Qualitative analysis is an interpretation of the obtained data within research and the result of data processing has been implemented by providing information and explanation. Data has complied validity, realibility and classical test is processed, so that those are resulting regression equation as follows: Where, Y = a + b1 X1 + b2 X2 Customer Satisfaction (Y), Service Quality variable (X1), service qualitu variable (X2), and Location variable (X3). Hyphothesis test uses t test demonstrates that the three of examined independent variables is proved significantly have a partially effect on dependent variable of Customer Satisfaction. Then, follow the F test can be recognized that the three of examined independent variables has a simultaneously effect on dependent variable of Customer Satisfaction
IT Competency Model for IT People
Authors: Yuniantoro Andi 
Published: March 2019

Speed of innovation in Information Technology will not aligned with speed of capability human resource in theorganization, if there is no strategy in human resource development especially in information technology.Information Technology and Human Resource need a framework that can link both as key success factor oforganization in implementation information technology. Framework will defined competency based on jobdescription IT people in organization, competency standard as reference in mapping with job description we can get from The European e-Competence Framework (e-CF) or SFIA (Skills Framework for the Information Age). After we get list of competency aligned with job description from IT people, we can mapping competency to job roles in organization structure. From this we already have a competency framework based on job description and related to job roles. We can use this framework for Human Resource Development in Information Technology, through assessment IT people based on competency framework, we can found gap competency of IT people and fulfill gap competency with training. Or we can use this competency framework for reward management of IT People, Career management of IT People, Training development of IT People and recruitment/selection of IT People.
The Applicability Blockchain in Indonesia Based on Indonesian Data Privacy Regulation
Authors: Fadlan Q , Amin Soetomo Mohammad Achmad , Mahawan Bagus 
Published: March 2019

Blockchain is a distributed ledger technology that has reliability in terms of maintaining data integrity and availability but not data privacy. Therefore, implementation of this particular unregulated technology must be reviewed to ensure compliance with relevant regulations, especially data privacy regulations which is this research main topic. For this reason, implementation of blockchain was observed in comparison with existing data privacy regulations in Indonesia. As initiation steps of research, data privacy regulations from Indonesia, Japan and Europe was used to be the input for the analysis of blockchain implementation. Two additionalinstruments, questionnaire and interview was used to produce an enhanced design for implementation of blockchain scheme in Indonesia. After the research was done, it was concluded that there is a possibility of blockchain implementation in Indonesia as long as the design was used with some notes as consideration.
PENINGKATAN KETERAMPILAN MEMBACA BERORIENTASI STRATEGI TPRC (THINK, PREDICT, READ, CONNECT) DI KELAS VI SEKOLAH ASAR NEGERI 023 PULAU KIJANG KECAMATAN RETEH
Authors: Rahmawati Rahmawati 
Published: March 2019

The subject of this research was the students of class VI of the State Primary School 023 Pulau Kijang, Reteh District, which amounted to 11 people. This study aims to improve students' reading skills which are rooted in the strategy of think, predict, read, connect (TPRC). The results of this study indicate, the initial data of students on reading skills amounted to 59.7 in the medium category, in the first cycle, the average value of students' reading skills increased to 76.03 in the high category. while in cycle II, the average value of students' reading skills again increased to 88.9 in very high categories. The increase in the average value seen from the basic score to the second cycle is 29.2 points. These results prove that the application of the TPRC strategy can improve reading skills of students in class VI of the State Primary School 023 Pulau Kijang.
KOMODITAS PERIKANAN UNGGULAN KABUPATEN PATI DALAM SKALA PROVINSI JAWA TENGAH
Authors: Damayanti Herna Octivia 
Published: March 2019

ENGLISHThe leading of Fishery commodities in Pati Regency are aquaculture pond fishery and marine capture fishery. Objectives of the research are (1) to describe the development of Pati Regency leading commodities in 2008-2012; (2) to describe the contribution of Pati Regency leading commodities to Central Java Province; and (3) to describe Pati Regency leading commodities position in Central Java Province scale. The research used descriptive method and was held in December 2013. Secondary data source namely marine capture fishery and aquaculture pond fishery production data from Statistics of Central Java Province for 2008, 2009, 2010, 2011 and 2012. Data was analyzed descriptively. The results were: (1) Both capture fishery and aquaculture pond fishery during the last 5 years (2008-2012) showed positive trend, that increased constantly; (2) the percentage of aquaculture pond fishery contribution is above 20% (range 23-28%), meanwhile marine capture fishery below 20% (range 15-18%); (3) Pati Regency marine capture fishery in 2008 and 2009 was ranked third , but three years later namely 2010, 2011 and 2012 managed to rank second in the Central Java Province scale. While, Pati Regency aquaculture pond fishery was ranked second in the last 5 years. INDONESIAHasil perikanan yang menjadi komoditas unggulan di Kabupaten Pati adalah komoditas perikanan budidaya tambak dan perikanan laut tangkap. Tujuan penelitian adalah (1) menggambarkan perkembangan hasil komoditas perikanan unggulan Kabupaten Pati tahun 2008-2012; (2) menggambarkan besaran kontribusi komoditas perikanan unggulan Kabupaten Pati kepada Provinsi Jawa Tengah; dan (3) menggambarkan posisi komoditas perikanan unggulan Kabupaten Pati dalam skala Provinsi Jawa Tengah. Penelitian menggunakan metode deskriptif dan dilaksanakan bulan Desember 2013. Sumber data sekunder yaitu data produksi perikanan laut tangkap dan perikanan budidaya tambak dari Badan Pusat Statistik Provinsi Jawa Tengah untuk tahun 2008, 2009, 2010, 2011 dan 2012. Analisis data secara deskripsif. Hasil penelitian adalah (1) hasil perikanan laut tangkap dan perikanan budidaya tambak Kabupaten Pati selama kurun waktu 5 tahun terakhir (2008-2012) menunjukkan tren positif yaitu terus mengalami peningkatan; (2) nilai persentase kontribusi perikanan budidaya tambak diatas 20% (kisaran 23-28%), sedangkan perikanan laut tangkap berada dibawah 20% (kisaran 15-18%); (3) hasil perikanan laut tangkap Kabupaten Pati pada tahun 2008 dan 2009 menduduki peringkat ketiga, tetapi 3 tahun selanjutnya yaitu tahun 2010, 2011 dan 2012 berhasil menduduki peringkat kedua dalam skala Provinsi Jawa tengah. Sedangkan perikanan budidaya tambak, Kabupaten Pati menempati peringkat kedua dalam 5 tahun terakhir.
PENGOLAHAN KOTORAN SAPI DENGAN TEKNOLOGI BIOGAS REAKTOR KECIL
Authors: Prayitno Hermain Teguh 
Published: March 2019

ENGLISHResearch on alternative energy and fertilizer has been done and applied, but the public not interest yet to make this alternative energy and fertilizer. This is due to the huge costs, the process is complicated, and low economic value . Biogas processing, liquid fertilizers and solid. If the large volume of water mix will increase the volume of the reactor and the implications for the huge cost . The research objective was to determine variations in the sample which is capable of representing the processing of the biogas process and product stability. The method used in laboratory scale experiments and determination of the best results using factor analysts . The results of the research is reactor B and A that can be used as a reference treatment that produces biogas manure optimal, and the volume of 0.56 liters of biogas per one kilogram of cow dung with a processing time of 38 days. INDONESIAPenelitian mengenai energi dan pupuk alternatif sudah banyak dilakukan dan diterapkan, akan tetapi minat masyarakat untuk membuat energi dan pupuk alternatif ini belum ada. Hal ini disebabkan oleh biaya yang besar, prosesnya yang rumit, dan nilai ekonominya rendah. Pengolahan biogas, pupuk cair dan padat. Jika dengan volume campuran air yang besar akan membesarkan volume reaktor dan berimplikasi pada besarnya biaya. Tujuan penelitian adalah untuk mengetahui variasi sampel mana yang mampu mewakili proses pengolahan dengan kesetabilan proses dan produk biogas. Metode yang digunakan percobaan skala laboratorium dan penentuan hasil terbaik menggunakan analis faktor. Hasil penelitian yaitu reaktor B dan A yang dapat digunakan sebagai acuan pengolahan kotoran sapi yang menghasilkan biogas optimal, dan volumenya 0,56 liter biogas setiap satu kilogram kotoran sapi dengan waktu pengolahan 38 hari.
STRATEGI PENGEMBANGAN INDUSTRI IKAN PINDANG SKALA SEDANG DAN BESARDI KABUPATEN PATI
Authors: Damayanti Herna Octivia 
Published: March 2019

ENGLISHProcessed form of marine fisheries that quite popular in Pati regency is boiled fish. The medium and large scale boiled fish industry can accelerate the growth of fishery and marine sector. The purpose of study is to formulate alternative strategies for developing medium and large scale boiled fish industries in Pati regency. The research used quantitative descriptive method and was condusted in March 2014. Primary data were obtained through interview with medium and large scale boiled fish employers, while secondary data were derived from relevant documents from marine and fisheries agency of Pati regency. Respondents were chosen using purposive sampling. Data were analyzed using SWOT and QSPM. Results of the research showed that the first priority strategy was improving the performance of association of boiled fish employers so it can be made a common agreement on the business management system and the boiled fish industry standard marketable products, with TAS value 4.948. INDONESIABentuk olahan hasil perikanan laut yang cukup populer di Kabupaten Pati adalah ikan pindang. Industri ikan pindang skala sedang dan besar dapat mempercepat pertumbuhan ekonomi dari sektor perikanan dan kelautan. Tujuan penelitian ini adalah untuk merumuskan alternatif strategi untuk pengembangan industri ikan pindang skala sedang dan besar di Kabupaten Pati. Penelitian ini menggunakan metode deskriptif kuantitatif dan dilaksanakan pada bulan Maret 2014. Sumber data primer yang diperoleh melalui wawancara dengan pengusaha pemindangan ikan skala sedang dan besar. Sedangkan data sekunder berasal dari dokumen relevan Dislautkan Kab. Pati. Metode pemilihan sampel responden dengan pendekatan purposive sampling. Analisis data dilakukan dengan analisis SWOT dan untuk menentukan prioritas strategi menggunakan analisis QSPM. Hasil penelitian yaitu prioritas strategi pertama adalah peningkatan kinerja wadah perhimpunan pengusaha ikan pindang sehingga dapat dibuat kesepakatan bersama tentang sistem manajemen usaha industri ikan pindang dan standar produk yang layak jual, dengan nilai TAS 4,948.
EFEKTIVITAS EFFLEURAGE MASSAGE UNTUK MENGURANGI NYERI PUNGGUNG PADA IBU HAMIL TRIMESTER III DI RB CI SEMARANG
Authors: Wulandari Dyah Ayu , Andryani Yuli 
Published: March 2019

Background: About 80% of women will feel back pain at some point during pregnancy. Most back pain during pregnancy occurs due to changes in the spinal muscles which are as much as 70%. and 30% of back pain during pregnancy may be due to irregularities in the condition of the spine that occurred earlier. Effleurage massage is a form of massage by using a palm that gives a gentle pressure to the top of the body in a circular direction repeatedly.Purpose: Knowing the scale of pain in pregnant women who have back trimester III back pain before and after effleurage massage done at RB CI Semarang.Research methods: Type of research used quantitative method, population in this research is trimester III pregnant woman in RB CI Semarang a number of 40 Respondent with collecting data obtained by doing effleurage massage with pre experimental design using pretest - postest one group design. Sampling technique in this research use Purposive Sampling technique.Results: the results obtained before the effleurage massage performed on pregnant women on average - scale pain 7, while after effleurage massage performed on average pregnant women decreased to pain scale 3. Conclusion:There is effect of effleurage massage on back pain in pregnant mother of trimester III.Keywords: effleurage massage, back painLiterature : 17 (2005 – 2017 ) AbstractAbout 80% of women will feel back pain at some point during pregnancy. Most back pain during pregnancy occurs due to changes in the spinal muscles which are as much as 70%. and 30% of back pain during pregnancy may be due to irregularities in the condition of the spine that occurred earlier.Effleurage massage is a form of massage by using a palm that gives a gentle pressure to the top of the body in a circular direction repeatedly.Knowing the scale of pain in pregnant women who have back trimester III back pain before and after effleurage massage done at RB CI Semarang.Type of research used quantitative method, population in this research is trimester III pregnant woman in RB CI Semarang a number of 40 Respondent with collecting data obtained by doing effleurage massage with pre experimental design using pretest - postest one group design. Sampling technique in this research use Purposive Sampling technique.the results obtained before the effleurage massage performed on pregnant women on average - scale pain 7, while after effleurage massage performed on average pregnant women decreased to pain scale 3. There is effect of effleurage massage on back pain in pregnant mother of trimester III.Keywords:effleurage massage, back pain
PENGARUH SENAM KAKI TERHADAP KADAR GULA DARAH PADA PASIEN DENGAN DIABETES MELITUS
Authors: Sukesi Niken 
Published: March 2019

Penyakit Diabetes Melitus dapat menyebabkan komplikasi yang sangat berat. Komplikasi dari Diabetes Melitus ini meliputi jantung iskemik, serebrovaskuler, gagal ginjal, ulkus pada kaki, gangguan penglihatan. Komplikasi yang paling sering terjadi adanya perubahan patologis pada anggota gerak bawah yang disebut kaki diabetik. Salah satu jenis olahraga yang dianjurkan dengan diabetes mellitus adalah senam kaki. Senam kaki merupakan latihan yang dilakukan bagi penderita DM atau bukan penderita untuk mencegah terjadinya luka dan membantu melancarkan peredaran darah bagian kaki. Penelitian ini bertujuan untuk menganalisis pengaruh senam kaki terhadap kadar gula darah pasien diabetes mellitus. Desain dalam penelitian ini adalah Quasy Eksperiment dengan rancangan Pre and Post Test Without Control. Teknik pengambilan sampel menggunakan Consecutive sampling. Alat pengumpul data yang digunakan instrument observasi senam kaki untuk menilai senam kaki, dan alat menilai kadar gula darah yaitu glucometer, kapas dan jarum. Rata-rata kadar gula darah sebelum dan setelah dilakukan senam kaki mengalami penurunan dan ada pengaruh kadar gula darah sebelum dengan sesudah dilakukan senam kaki pada pasien diabetes melitusKata Kunci: Senam Kaki, Kadar Gula Darah THE EFFECT OF GYMNASTIC FEET TOWARD THE BLOOD SUGAR LEVEL FOR THE DIABETICSDiabetes Mellitus causes the complication case. It concludes the heart iskemik, serebrovaskuler, cronic kidney disease, ulcus on the feet, and the impairment of sight. The complication often causes the changing of pathological in certain place such as feet. The one of recommended sport for diabetics is gymnastic feet. Gymnastic feet is an experience for diabetics or not in order to prevent the wound and launch the blood circulation. The research objective is to analyze the effect of gymnastic feet to blood sugar level for diabetics. The research design is using experiment quasy with pre and post test without control. It is using consecutive sampling as the sample of collecting technique, and using observation of gymnastic feet as the collecting data technique to assess the blood sugar level, those are glucometer, cotton, and needle. The average of blood sugar level is decrease after doing the gymnastic feet. Moreover, there is differences between after and before doing the gymnastic feet for diabetics.Key Words : Gymnastic Feet, Blood sugar level