bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Zoledronic Acid in a Neonate with Subcutaneous Fat Necrosis Complicated with Severe, Refractory Hypercalcemia
Authors: Militello Maria Angela , Re Maria Paola , Vitaliti Giuliana , Finazzo Francesca , Manzoni Paolo , Vitaliti Salvino Marcello 
Published: July 2019

Objective Subcutaneous fat necrosis (SCFN) is a rare condition that may occur in the neonatal period. SCFN is an inflammatory disorder of the adipose tissue, usually found in full-term healthy infants who have a history of intrauterine or perinatal distress. It is usually a self-limited condition; however, in some cases, it can get complicated, leading to severe hypercalcemia that may be life-threatening.
Study Design We report and describe a classic presentation of SCFN that led to severe hypercalcemia refractory to standard treatment. The diagnosis of SCFN was made based on the finding of subcutaneous nodules and of hypercalcemia. The serum calcium level reached 16.6 mg/dL. Hypercalcemia was treated first with intravenous infusions of fluids and furosemide and then of methylprednisolone. This standard treatment was not effective; therefore, we administered a single low dose of zoledronic acid, which, in turn, was efficacious in ultimately managing the hypercalcemia.
Conclusion Our case shows how a single low dose of zoledronic acid was safe and effective in managing severe hypercalcemia unresponsive to conventional treatment while minimizing the risk of hypocalcemic rebounds.
Community-Acquired Pneumonia in Children: Myths and Facts
Authors: Yun Ki Wook , Wallihan Rebecca , Juergensen Alexis , Mejias Asuncion , Ramilo Octavio 
Published: July 2019

AbstractCommunity-acquired pneumonia (CAP) is the leading cause of death in children < 5 years of age worldwide. It is also one of the most frequent infectious diseases in children, leading to large antibiotic use and hospitalization even in the industrialized countries. However, the optimal management of CAP in children is still not well defined. Currently, respiratory viruses are considered the most frequent etiologic agents, but detection of viruses in the upper respiratory tract does not guarantee causation of pneumonia, nor precludes the presence of a bacterial pathogen. In both the upper and lower respiratory tract, respiratory viruses and pathogenic bacteria interact. Emerging evidence indicates that dual viral–bacterial infections function synergistically in many cases and together likely enhance the severity of CAP. Therefore, new and advanced technologies capable of sensitively and specifically discriminating viral, bacterial, and viral–bacterial coinfections are needed. Instead of focusing on the pathogen, analysis of host immune transcriptome profiles from children with CAP can potentially offer diagnostic signatures, help to assess disease severity, and eventually, prognostic indicators. An optimized management strategy by using molecular pathogen testing and transcriptome profiling will facilitate prompt, more appropriate, and targeted therapies, which in turn will lead to improved clinical outcomes in children with CAP.
Recent Trends in RSV Immunoprophylaxis: Clinical Implications for the Infant
Authors: Acero-Bedoya Santiago , Wozniak Phillip S. , Sánchez Pablo J. , Ramilo Octavio , Mejias Asuncion 
Published: July 2019

AbstractRespiratory syncytial virus (RSV) remains the leading cause for hospitalizations in infants worldwide, resulting in significant health and financial burden. Since 1998, the humanized monoclonal antibody palivizumab remains the only available option licensed for the prevention of severe RSV disease in high-risk children, namely premature infants and those with chronic lung disease and congenital heart disease. In 2014, the American Academy of Pediatrics modified the recommendations on the use of RSV prophylaxis in these high-risk children, and limited its use to premature infants born at < 28 weeks' gestational age (wGA). Following this last guidance update, studies have confirmed that premature infants of 29 to 34 wGA remain at high risk for severe RSV disease, especially those of younger chronologic age. New and more cost-effective strategies are being developed that would help alleviate both the health and financial burden associated with severe RSV disease.
Trans-oral, Carbon Dioxide-Assisted Excision of an Unusual Schwannoma of the Tongue Base: Case Report and Review of the Literature
Authors: Soliman Zakaria Raee , Mobashir Mohammad Kamal , Askar Sherif Mohammad 
Published: July 2019

Introduction Schwannomas are benign, solitary, encapsulated tumors that may originate at any site of the peripheral nervous system, with the exception of the olfactory and optic nerves. Schwannomas of the base of tongue are very rare, and only sporadic cases are documented. The tongue base represents a challenge for surgeons. Carbon dioxide (CO2) laser might provide an effective surgical option for such lesions because of the easy access to the lesion, the bloodless surgical field and optimum epithelization of wounds.
Objective We present an unusual case of pedunculated schwannoma of the tongue base treated via transoral CO2-assisted excision. We also provide a review of the available literature, in English language, on humans.
Data synthesis The authors searched the PubMed database and Google up to July 2018. The following search terms were applied: tongue and lingual, combined with schwannoma and neurilemmoma. Titles and abstracts were screened, and, then, only supraglottic (hypopharyngeal) tongue base masses were considered. Fourteen articles were included in this review, reporting 17 cases. The age of the patients ranged from 9 to 39 years, affecting predominantly females. Dysphagia and lump sensations were the most common presenting symptoms, and the mean follow-up period range was 1.5 to 60 months (mean = 13 months). There was no evidence of recurrence in any of the cases.
Conclusion We could conclude that tongue base schwannomas are rare. Transoral complete excision of the tumor is the treatment of choice. CO2 laser surgery is a minimally invasive treatment option that has been performed in few reports with no recurrence and with favorable outcomes.
Chorioamnionitis and Infectious Complications after Vaginal Delivery
Authors: DeNoble Anna E. , Heine R. Phillips , Dotters-Katz Sarah K. 
Published: July 2019

Objective To estimate the incidence of and define risk factors for postpartum infectious complications after vaginal birth after cesarean (VBAC) complicated by chorioamnionitis.
Study Design A secondary analysis of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Unit Cesarean Registry was performed. The primary outcome was a composite of postpartum infection: endometritis, sepsis, pelvic abscess, urinary tract infection, necrotizing fasciitis, and septic pelvic thrombophlebitis. Peripartum predictors were compared using parametric and nonparametric tests, as appropriate, and multivariate predictors assessed using logistic regression.
Results A total of 559 subjects had chorioamnionitis in labor and a successful VBAC. Twenty-four (4.3%) subjects experienced the primary outcome, mainly due to endometritis (19/24). Significant factors included preterm delivery <32 weeks (odds ratio [OR]: 3.05, 95% confidence interval [CI]: 1.32–7.06) and body mass index (BMI) ≥40 (OR: 4.63, 95% CI: 1.25–17.14). Receipt of postpartum antibiotics was protective against postpartum infection (OR: 0.28, 95% CI: 0.12–0.65). In multivariate analysis, preterm delivery <32 weeks, BMI ≥40, and receipt of postpartum antibiotics remained associated with postpartum infection.
Conclusion Nearly 5% of women with chorioamnionitis had a postpartum infectious complication after vaginal delivery, with higher rates in those delivering at <32 weeks and with prepregnancy BMI ≥40. Receipt of postpartum antibiotics decreased the odds of postpartum infection markedly.
MRI Study on the Distance between the Distal Radius and the Flexor and Extensor Tendons: Is There Any Room for Error/Hardware?
Authors: Bergsma Minke , Board Jemara , Doornberg Job N. , Sierevelt Inger , Rickman Mark , Jaarsma Ruurd L. , Obdeijn Miryam C. 
Published: July 2019

Abstract
Purpose This study aims to quantify the distances between the cortex of the distal radius and flexor and extensor tendons.
Methods We analyzed 50 magnetic resonance images (MRI) of intact wrist without pathology. The distances between the volar cortex and the flexor pollicis longs (FPL), index flexor digitorum profunduns (FDPi), flexor digitorum profundus (FDP), and flexor digitorum superficialis (FDS) were measured at the level of the watershed line and 3- and 6-mm proximal to this level. The distances between the dorsal cortex and the extensor carpi radialis longus (ECRL), extensor carpi radialis brevis (ECRB), extensor pollicis longus (EPL), extensor indicis proprius (EIP), and the extensor digitorum communis (EDC) were measured at the level of Lister's tubercle and 5-mm distal to this level. Analysis was descriptive.
Results At the watershed line, the FPL, FDPi, FDP, and FDS were located at an average of 3.1, 2.4, 3.6, and 5.1 mm, respectively, volar to the volar cortex. The distances of the FDP and FDS increased at 3-mm proximal to the watershed line and increased for all four tendons at 6-mm proximal to the watershed line. Dorsally, at Listers' tubercle the ECRL, ECRB, EPL, EIP, and EDC were identified at an average of 0.7, 0.5, 0.5, 2.6, and 3.2 mm, respectively, dorsal to the dorsal cortex of the distal radius. At 5-mm more distal, these tendons were located on average 1.2, 1.0, 0.7, 1.9, and 1.8 mm, respectively, dorsal to the dorsal cortex.
Conclusion On the volar side, on average there is enough room for a volar plate when staying proximal to the watershed line. On the dorsal side, there is virtually no room for protruding screws as physical anatomical space is limited to a maximum of 0.7 mm from cortex to the closest tendon (the FDP), with screw increments being 2 mm.
Level of Evidence This is a Level II Study.
Disfluency in relay and non-relay simultaneous interpreting
Authors: Song Shuxian , Cheung Andrew K. F. 
Published: July 2019

Abstract
This corpus-based study explores the effects of relay interpreting at meetings of the United Nations General
Assembly by comparing features of disfluency between the outputs of relay and non-relay simultaneous interpreting (SI). The
findings are as follows: (1) the output of relay interpreting is shorter and more dispersive than that of non-relay interpreting;
(2) filled pauses are the most common type of disfluency; and (3) the relay SI output shows fewer lexical and phonetic E-repairs
and more A-repairs for ambiguity, syntactic E-repairs, and D-repairs than the non-relay output. The results suggest that the use
of relay vs. non-relay interpreting may affect interpreters’ output.
Collectivity in small and large collision systems at the LHC with ALICE
Authors: Gajdošová Katarína Křížková 
Published: July 2019

Abstract
Interactions of protons (pp) or of a proton with a lead nucleus (p–Pb) were not expected to form a deconfined hot and dense matter, called the Quark-Gluon Plasma (QGP), which is instead produced in heavy-ion collisions. However, high-multiplicity events in small collision systems exhibit signs of collectivity, which are understood as a signature of the QGP emergence in heavy-ion collisions. An excellent tool to probe the presence of collectivity is the anisotropic flow measured with two- and multi-particle cumulants. In these proceedings, we present the first measurement of flow coefficients and their magnitude correlations using symmetric cumulants for charged particles in pp collisions at centre-of-mass energies of

s

=
13

TeV

, p–Pb at

S

N
N

=
5.02

TeV

, Xe–Xe at

S

N
N

=
5.44

TeV

and Pb–Pb collisions at

S

N
N

=
5.02

TeV

, collected during the LHC Run 2 programme. In addition, the flow coefficients of identified particles in p–Pb collisions are shown. Such a broad spectrum of colliding systems with different energies and a wide range of multiplicity allows for a detailed investigation of their collision dynamics. Non-flow effects, which are azimuthal correlations not originating from a common symmetry plane, are suppressed with the pseudorapidity separation and the subtraction method. These results provide an important insight into the nature of collective phenomena in different collision systems.
Composite Models on a safe road to the Planck scale
Authors: Cacciapaglia Giacomo , Ma Teng , Wu Yongcheng 
Published: July 2019

Abstract
We present the first serious attempt to define a model of composite pseudo-NambuGoldstone Higgs with partial compositeness for all standard fermions that is valid up to the Planck scale. The main ingredient is the presence of a large multiplicity of fermions in the microscopic gauge-fermion description, which allows us to use large-Nf
techniques to show the presence of an interactive UV fixed point for the gauge couplings (UV safety). We also present results for the Dark Matter relic density and direct detection in the example model that is UV-completed.
Dark matter, collider searches and the early Universe
Authors: Mahmoudi Farvah 
Published: July 2019

Abstract
Big-Bang nucleosynthesis (BBN) represents one of the earliest phenomena which can lead to observational constraints on the early Universe properties. Yet, it is well-known that many important mechanisms and phase transitions occurred before BBN. We will discuss the possibility to gain insight about the primordial Universe through studies of dark matter in cosmology, astroparticle physics and colliders. For this purpose we consider that dark matter is a thermal relic, and show that combining collider searches with dark matter observables can lead to strong constraints on the cosmological freeze-out period.
MAGIC - how MAtter’s extreme phases can be revealed in Gravitational wave observations and in relativistic heavy Ion Collision experiments
Authors: Hanauske Matthias , Bovard Luke , Steinheimer Jan , Motornenko Anton , Vovchenko Volodymyr , Schramm Stefan , Dexheimer Veronica , Papenfort Jens , Most Elias R. , Stöcker Horst 
Published: July 2019

Abstract
Nearly one hundred years after Albert Einstein developed the field equations of general relativity and predicted the existence of gravitational waves, a gravitational wave event from a binary neutron star merger (GW170817) was detected in August 2017 by the LIGO/VIRGO collaboration. During the thereon analysis of the gravitational wave data, the equation of state of elementary matter could be constrained in the regime of high densities/temperatures. Recent simulations show, that the appearance of a hadron to quark phase transition in the interior region of a hybrid star merger remnant might change the overall properties of the merger event and could be detectable in future. On the one hand, 4D-simulations of binary neutron star mergers show that these astrophysical systems represent optimal laboratories to investigate the phase structure of quantum chromodynamics. On the other hand, accelerators like the FAIR facility at GSI Helmholtzzentrum allow one to study the properties of the quark-gluon plasma produced in relativistic collisions of heavy ions. This article combines a survey of recent advancements in two rather distinct fields, which reveal - on first sight - a surprising similarity of both, namely relativistic collisions of nuclei and of neutron star mergers.
Detecting opioid metabolites in exhaled breath condensate (EBC)
Authors: Borras Eva , Cheng Andy , Wun Ted , Reese Kristen L , Frank Matthias , Schivo Michael , Davis Cristina E 
Published: July 2019

Abstract
Exhaled breath condensate (EBC) collection provides a promising matrix for bioanalysis of endogenous biomarkers of health and also for exogenous compounds like drugs. There is little information regarding drugs and their metabolites contained in breath, as well as their pharmacokinetics. In this present work, we use a simple and non-invasive technique to collect EBC from chronic pain patients using different analgesic opioid drugs to manage pain. Six patients received continuous infusion of morphine and hydromorphone intravenously (IV), together with other analgesic drugs (IV and orally). Repeated sampling of serum and EBC was done at two time points separated by 90 min. The EBC was collected using a glass tube surrounded by dry ice, and an ethanol solvent wash of the glass was performed after EBC extraction to retrieve the apolar compounds stuck to the glass surface. All samples were analyzed with liquid chromatography coupled to mass spectrometry (LC-MS/MS) to identify possible metabolites present in the sample, and to quantify the drugs being used. Several metabolites, such as normorphine (norM), norhydromorphone (norHM) and dihydromorphone (diHM) were detected in both fractions, while hydromorphone 3-glucuronide (HM 3G) was only detected in the solvent rinse fraction. Results were correlated to explain the pharmacokinetics of the main drugs administered. This pilot study presented promising correlations between drug concentrations in blood and breath at different time points for norM, norHM and HM 3G.
Social Protection for Elderly in Emergency (Case Study: Yogyakarta Special Region, Indonesia)
Authors: Khotimah N. , Fitriana K.N. , Pratiwi P.H. 
Published: July 2019

Abstract
Yogyakarta Special Region in 2012 had the highest percentage of elderly population in Indonesia (13.04%), in 2020 it is predicted to reach 14.7%, and in 2030 it will reach 19.5%. The government in Yogyakarta Special Region needs to make a responsive policy of the increase in number of elderly people, considering that the elderly with various problems faced will become vulnerable in the event of a disaster. This study aims to develop a disaster management strategy oriented to social protection for the elderly in emergency. The research focused on Yogyakarta Special Region with the main consideration that Yogyakarta Special Region has the highest proportion of elderly people in Indonesia and has various potential disasters. Data collection techniques in this study used the method of observation, in-depth interviews, focus group discussion (FGD), and documentation studies. The data that has been collected then analyzed descriptive qualitatively. The research find that disaster management strategic for realizing social protection for the elderly in emergencies include: (1) establishing a coordination mechanism and legal framework for disaster risk reduction, (2) integrating the concept of disaster risk on all regional and resource development rules and plans, (3) improving the flow and effective ways to share information about disaster, (4) increasing public awareness of disaster impacts and risks, and (5) integrating relation between multi-stakeholder and involving the real role of community where living in disaster-prone areas. The form of participatory social services to support the realization of social protection for the elderly in an emergency condition are directed through home care services, assisting productive economic empowerment, mentoring religious activities, and mentoring psycho-emotional activities.
School Preparedness in Anticipating the Threat of Earthquake and Tsunami in Bantul Regency
Authors: Khotimah N. , Purwantara S. , Dewi U. , Majima K. , Hiroyuki K. 
Published: July 2019

Abstract
Earthquakes occurring in the subduction zone are the cause of the tsunami. This study aims to determine: (1) school preparedness in Bantul Regency in to face of the earthquake and tsunami disaster, and (2) school efforts in Bantul Regency in improving the preparedness of the earthquake and tsunami disaster. The research design used in this research is descriptive analysis. This research conducted on April-November 2018. The research places is Bantul Regency, D.I. Yogyakarta. Variables in this study are school preparedness in to face of the earthquake and tsunami disaster (knowledge, policies and guidelines, emergency response plans, disaster warning systems, and resource mobilization) and school efforts in improving the preparedness of the earthquake and tsunami disaster. The population of this study is all schools in Bantul Regency that enter the area prone to earthquake and tsunami disaster. All members of the population is expected to be a unit of research analysis. Data collection techniques in this study are observation, interviews, and documentation. The data analysis used in this research is quantitative and qualitative. The results showed: (1) school preparedness in Bantul Regency from the schools aspect in “ready enough” category (76.9 %), the teachers aspect in “full ready” category (73.1%), and the students aspect in “full ready” category (60.1%). (2) Efforts to improve the preparedness of the earthquake and tsunami disaster carried out by schools in Bantul Regency, including: (a) conducting earthquake and tsunami disaster evacuation drills in their school communities, (b) improving school preparedness, teachers preparedness, students preparedness, parents preparedness and volunteers preparedness with various trainings and simulations in the face of the earthquake and tsunami disaster, (c) making routes and evacuation maps, (d) mobilizing all available resources, from the public and private sectors, domestic and foreign to coordinate all disaster response entities based on emergency response plans, (e) integration of earthquake and tsunami disaster studies in the curriculum in schools, and (f) involve the role of various parties in improving the preparedness of the earthquake and tsunami disaster
Volcanic Springs, An Alternative Emergency Water Resource to Support Sustainable Disaster Management in Southern Flank of Merapi Volcano
Authors: Ratih S , Awanda H N , Saputra A C , Ashari A 
Published: July 2019

AbstractThe activities of Merapi Volcano which still pose risks over time require good and sustainable disaster management. Identification of potential water resources that can be utilized in disaster emergency situations is needed to support the management of the disaster. For the southern slope of Merapi Volcano as an area directly affected by the eruption in 2010, the availability of water resources and infrastructure is a very important part to be ensured in the pre-disaster phase. This paper aims: (1) analyze the potential of springs, (2) analyze the spatial pattern of the distribution of springs with the distribution of population settlements, (3) design the use of springs for handling disaster emergencies; in disaster eruption prone area of the southern flank of Merapi Volcano. To achieve these objectives a field survey and secondary data collection were carried out through library research and document tracking. The data that has been obtained is then analyzed descriptively with a geographic approach supported by the application of geographic information system analysis. The results: (1) The area of southern flank of Merapi Volcano has many springs with varying quantity and quality, which generally can be used to meet water resource needs in disaster emergency situations. (2) the distribution of springs in disaster-prone areas is clustered according to geomorphological factors, while the distribution of settlements is random. The pattern of spreading of springs and settlements needs to be considered to determine the spring regulation system to meet the needs of the population, in addition to other considerations, namely population, population density, water needs per capita and administrative factors, (3) in this writing several wells have been chosen which can be used to fulfill needs in disaster emergency situations. In conclusion, the active volcanic area has a very good potential for springs which can be used to meet resource needs in disaster emergency situations. Management of existing potential well is very necessary in supporting sustainable disaster management.