bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perfil clínico-epidemiológico de pacientes com hanseníase atendidos em hospital universitário no Rio de Janeiro entre 2008 e 2017
Authors: Menezes Vinicius Martins de , Guedes Juliana Chaves Ruiz , Fernandes Larissa Starling de Albuquerque , Haddad Natacha de Mello , Lima Ricardo Barbosa , Martins Elizabeth Santana , Martins Carlos José 
Published: July 2019

Modelo do estudo: Estudo observacional, longitudinal, retrospectivo e descritivo de uma coorte de pacientes.
Objetivo: Descrever o perfil clínico e epidemiológico dos pacientes com diagnóstico de hanseníase, atendidos em um centro de referência no estado do Rio de Janeiro.
Metodologia: Foram incluídos todos os pacientes com diagnóstico de hanseníase atendidos no Hospital Universitário Gaffrée e Guinle entre os anos de 2008 a 2017. Os dados foram coletados através da revisão de prontuários e analisados através de estatística descritiva, utilizando-se o software SPSS 22.0 database . Resultados: Um total de 112 pacientes foi incluído no estudo, sendo que 54,5% eram do sexo masculino. A média de idade foi de 49,9 anos, 62,4% eram moradores do município do Rio de Janeiro e 69,9% apresentaram formas clínicas multibacilares da hanseníase. Foi possível avaliar o grau de incapacidade inicial de 36 (32,1%) dos pacientes incluídos. Desses, 25% apresentaram grau de incapacidade inicial II. Durante o tratamento poliquimioterápico, 21 (18,8%) pacientes apresentaram algum efeito colateral, sendo o mais comum a anemia relacionada à dapsona. Cinquenta e nove (52,7%) pacientes apresentaram algum tipo de estado reacional da hanseníase e 10 (8,9%) apresentaram complicações sistêmicas graves durante o acompanhamento.
Conclusões: O presente estudo evidenciou um perfil clínico-epidemiológico diferente do descrito na literatura, com uma grande porcentagem de pacientes com grau de incapacidade inicial II, uma alta frequência de estados reacionais e de complicações advindas do curso clínico da doença ou dos tratamentos implementados.
Evaluation and Bias Correction of S2S Precipitation for Hydrological Extremes
Authors: Li Wei , Chen Jie , Li Lu , Chen Hua , Liu Bingyi , Xu Chong-Yu , Li Xiangquan 
Published: July 2019

AbstractSubseasonal to seasonal (S2S) weather forecasting has made significant advances and several products have been made available. However, to date few studies utilize these products to extend the hydrological forecast time range. This study evaluates S2S precipitation from eight model ensembles in the hydrological simulation of extreme events at the catchment scale. A superior bias correction method is used to correct the bias of S2S precipitation for hydrological forecasts, and the results are compared with direct bias correction of hydrological forecasts using raw precipitation forecasts as input. The study shows that the S2S models can skillfully forecast daily precipitation within a lead time of 11 days. The S2S precipitation data from the European Centre for Medium-Range Weather Forecasts (ECMWF), Korea Meteorological Administration (KMA), and United Kingdom’s Met Office (UKMO) models present lower mean error than that of other models and have higher correlation coefficients with observations. Precipitation data from the ECMWF, KMA, and UKMO models also perform better than that of other models in simulating multiple-day precipitation processes. The bias correction method effectively reduces the mean error of daily S2S precipitation for all models while also improving the correlation with observations. Moreover, this study found that the bias correction procedure can apply to either precipitation or streamflow simulations for improving the hydrological forecasts, even though the degree of improvement is dependent on the hydrological variables. Overall, S2S precipitation has a potential to be applied for hydrological forecasts, and a superior bias correction method can increase the forecasts’ reliability, although further studies are still needed to confirm its effect.
Evaluation of X-Band Dual-Polarization Radar-Rainfall Estimates from OLYMPEX
Authors: Derin Yagmur , Anagnostou Emmanouil , Anagnostou Marios , Kalogiros John 
Published: July 2019

Abstract
The difficulty of representing high rainfall variability over mountainous areas using ground-based sensors is an open problem in hydrometeorology. Observations from locally deployed dual-polarization X-band radar have the advantage of providing multiparameter measurements near ground that carry significant information useful for estimating drop size distribution (DSD) and surface rainfall rate. Although these measurements are at fine spatiotemporal scale and are less inhibited by complex topography than operational radar network observations, uncertainties in their estimates necessitate error characterization based upon in situ measurements. During November 2015–February 2016, a dual-polarized Doppler on Wheels (DOW) X-band radar was deployed on the Olympic Peninsula of Washington State as part of NASA’s Olympic Mountain Experiment (OLYMPEX). In this study, rain gauges and disdrometers from a dense network positioned within 40 km of DOW are used to evaluate the self-consistency and accuracy of the attenuation and brightband/vertical profile corrections, and rain microphysics estimation by SCOP-ME, an algorithm that uses optimal parameterization and best-fitted functions of specific attenuation coefficients and DSD parameters with radar polarimetric measurements. In addition, the SCOP-ME precipitation microphysical retrievals of median volume diameter D0 and normalized intercept parameter NW are evaluated against corresponding parameters derived from the in situ disdrometer spectra observations.
Increased risk of esophageal squamous cell carcinoma associated with frequent and long-term consumption of salted meat and salted fat
Authors: Zhao Lin , Li Yu-Chen , Wu Jiang-Ping , Zhao Yan-Jie , Wang Rui-Bin , Jiang Min , Song Qing-Kun 
Published: July 2019

Objective This study aimed to investigate the association between the consumption of salted meat and salted fat and esophageal cancer risk among individuals with normal esophageal mucosa or esophagitis. Methods This case-control study enrolled 216 individuals from Yanting County. Information on the consumption of salted meat and salted fat was collected using a food-frequency questionnaire validated among Yanting people. Results Higher intake frequencies (≥once a week) of salted meat and salted fat were associated with 2.40-fold and 7.37-fold increased risks of esophageal cancer among individuals with normal esophageal mucosa, while long-term intakes (≥6 months) increased the risks by 6.87-fold and 85.45-fold, respectively. Similarly, the odds ratios (ORs) of patients with esophagitis developing esophageal cancer from frequent intakes of salted meat and salted fat were 6.48 and 5.05, respectively, and the ORs associated with long-term intakes were 44.38 and 74.90, respectively. Conclusions Frequent and long-term consumption of salted meat and salted fat could increase the risk of esophageal cancer in individuals from Yanting with normal esophageal mucosa or esophagitis. Efforts should thus be made to reduce the consumption of these foods among people in this region.
Assessment of patients’ psychological state and self-efficacy associated with postoperative constipation after thoracolumbar fracture surgery
Authors: Jing Deng , Jia Li 
Published: July 2019

Objective We aimed to explore the relationship among the duration of constipation at 30 days after thoracolumbar fracture surgery, self-efficacy, and anxiety or depression in patients with constipation after thoracolumbar fracture surgery. Methods In this descriptive correlational study, 108 patients with thoracolumbar fracture undergoing pedicle screw fixation surgery were recruited from January 2015 to May 2017 in our hospital. From the day of surgery, we conducted a 1-month follow-up investigation. We evaluated the pattern of defecation, stool consistency, and incidence of defecation-related problems using a structured interview. Clinical data were obtained using a patient intake form, and we applied the Health Behavior Self-Efficacy Scale (HBSES), and Hospital Anxiety and Depression Scale (HADS). Results Approximately 83.3% of patients experienced postoperative constipation, and most exhibited normal defecation by postoperative day 13. Self-efficacy and anxiety and depression were graded at a medium level in most patients. The average HBSES score was 74.39 ± 11.08, and the mean HADS score was 7.97 ± 4.08. The duration of postoperative constipation was negatively correlated with self-efficacy and positively associated with anxiety or depression. Conclusions Self-efficacy, anxiety, and depression are important sociopsychological factors associated with the duration of postoperative constipation.
Clinical features and risk factors of acute kidney injury in children with acute paraquat intoxication
Authors: Song Yue , Li Chaofeng , Luo Fenglan , Tao Yuhong 
Published: July 2019

Objective This study aimed to investigate the clinical features and risk factors of acute kidney injury (AKI) in children with acute paraquat intoxication. Methods A retrospective study of 110 hospitalized children with acute paraquat intoxication in West China Second University Hospital, Sichuan University was conducted from January 2010 to May 2017. The Kaplan–Meier method was used to compare the survival rates of children with different AKI stages. Multivariate logistic regression was applied to analyse the risk factors for paraquat-induced AKI. Results AKI occurred in 42 of 110 (38.2%) children. We observed AKI stage 1 in two (4.8%) children, AKI stage 2 in 11 (26.2%), and AKI stage 3 in 29 (69.0%). The survival rate of children in AKI stage 3 (34.5%) was significantly lower than that in children in AKI stage 2 (63.6%) and AKI stage 1 (100%). Multivariate analysis showed that oral ulcers and elevated blood glucose levels were significant independent risk factors for paraquat-induced AKI in children (odds ratio = 4.223 and 5.545, respectively). Conclusions The incidence and mortality rates of paraquat-induced AKI in children are high. Oral ulcers and elevated blood glucose levels are independent risk factors affecting the occurrence of paraquat-induced AKI in children.
Stem Cell–Conditioned Medium Promotes Graft Remodeling of Midsubstance and Intratunnel Incorporation After Anterior Cruciate Ligament Reconstruction in a Rat Model
Authors: Sun Yaying , Chen Wenbo , Hao Yuefeng , Gu Xueping , Liu Xingwang , Cai Jiangyu , Liu Shaohua , Chen Jiwu , Chen Shiyi 
Published: July 2019

Background: Stem cell–conditioned medium (CM) has been increasingly used in regenerative medicine. However, its effect on graft-host integration after anterior cruciate ligament (ACL) reconstruction (ACLR) remains unclear. Purpose: To examine the effect of human bone marrow stem cell (hBMSC)–CM on graft-bone integration and graft midsubstance ligamentization in a rat model of ACLR. Study Design: Controlled laboratory study. Methods: CM was obtained from the supernatant of commercially available hBMSCs in serum-free Dulbecco’s modified Eagle medium (DMEM). In a rat model of an ACL injury, isometric ACLR was performed. Three groups were established: CM injection group (CM; n = 40), control injection group (CI; n = 40) with serum-free DMEM injections, and no injection group (NI; n = 40). An intra-articular injection was performed weekly. Micro–computed tomography was conducted at 2, 4, and 8 weeks postoperatively. Histological and biomechanical analyses were conducted at 4 and 8 weeks postoperatively. The NIH3T3 fibroblast was utilized as a model in vitro to examine the effect of CM using the cell counting kit–8 (CCK-8) assay and immunofluorescence staining of Ki-67, α–smooth muscle actin (α-SMA), and collagen 1 (Col 1). Results: At 4 and 8 weeks, the femoral and tibial bone tunnel areas as well as the interface between the graft and host bone were smaller, while the bone volume/total volume ratio was higher, in the CM group. Sharpey-like fibers formed at 8 weeks in the CM group. At 4 and 8 weeks, more Col 1 was noticed in the CM group than in the NI group (both P < .001) or CI group (both P < .001). Immunohistochemically, the α-SMA–positive area was up-regulated at the graft-bone interface at 4 weeks ( P < .001) and declined at 8 weeks ( P < .001) in the CM group compared with the other 2 groups. At the midsubstance, α-SMA expression decreased from 4 to 8 weeks in all groups and was significantly lower in the CM group than in the NI group ( P < .01) or CI group ( P < .05) at 8 weeks. The CCK-8 assay showed that CM increased NIH3T3 viability ( P < .001) and the level of Ki-67 ( P < .05), α-SMA ( P < .001), and Col 1 ( P < .001) in CM-educated NIH3T3 cells. Conclusion: hBMSC-CM accelerates graft-bone incorporation and midsubstance ligamentization and enhances the proliferation, differentiation, and collagen synthesis of fibroblasts. Clinical Relevance: Graft-host integration is essential after ACLR. The current study identified a novel agent, that is, hBMSC-CM, as a candidate for promoting integration.
Transplantation of Aggregates of Autologous Synovial Mesenchymal Stem Cells for Treatment of Cartilage Defects in the Femoral Condyle and the Femoral Groove in Microminipigs
Authors: Kondo Shimpei , Nakagawa Yusuke , Mizuno Mitsuru , Katagiri Kenta , Tsuji Kunikazu , Kiuchi Shinji , Ono Hideo , Muneta Takeshi , Koga Hideyuki , Sekiya Ichiro 
Published: July 2019

Background: Previous work has demonstrated that patients with cartilage defects of the knee benefit from arthroscopic transplantation of autologous synovial mesenchymal stem cells (MSCs) in terms of magnetic resonance imaging (MRI), qualitative histologic findings, and Lysholm score. However, the effectiveness was limited by the number of cells obtained, so large-sized defects (>500 mm2) were not investigated. The use of MSC aggregates may enable treatment of larger defects by increasing the number of MSCs adhering to the cartilage defect. Purpose: To investigate whether transplantation of aggregates of autologous synovial MSCs with 2-step surgery could promote articular cartilage regeneration in microminipig osteochondral defects. Study Design: Controlled laboratory study. Methods: Synovial MSCs derived from a microminipig were examined for in vitro colony-forming and multidifferentiation abilities. An aggregate of 250,000 synovial MSCs was formed with hanging drop culture, and 16 aggregates (for each defect) were implanted on both osteochondral defects (6 × 6 × 1.5 mm) created in the medial femoral condyle and femoral groove (MSC group). The defects in the contralateral knee were left empty (control group). The knee joints were evaluated at 4 and 12 weeks by macroscopic findings and histology. MRI T1rho mapping images were acquired at 12 weeks. For cell tracking, synovial MSCs were labeled with ferucarbotran before aggregate formation and were observed with MRI at 1 week. Results: Synovial MSCs showed in vitro colony-forming and multidifferentiation abilities. Regenerative cartilage formation was significantly better in the MSC group than in the control group, as indicated by International Cartilage Repair Society score (macro), modified Wakitani score (histology), and T1rho mapping (biochemical MRI) in the medial condyle at 12 weeks. Implanted cells, labeled with ferucarbotran, were observed in the osteochondral defects at 1 week with MRI. No significant difference was noted in the modified Wakitani score at 4 weeks in the medial condyle and at 4 and 12 weeks in the femoral groove. Conclusion: Transplantation of autologous synovial MSC aggregates promoted articular cartilage regeneration at the medial femoral condyle at 12 weeks in microminipigs. Clinical Relevance: Aggregates of autologous synovial MSCs could expand the indications for cartilage repair with synovial MSCs.
Angiography and phlebography in a hemodialysis population: A retrospective analysis of interventional results
Authors: Hadimeri Ursula , Wärme Anna , Nasic Salmir , Fransson Sven-Göran , Wigelius Ann , Stegmayr Bernd 
Published: July 2019

Objective: To clarify the reasons and beneficial effects and duration of arteriovenous fistula patency after radiological interventions in arteriovenous fistula. The patients investigated were referred due to arteriovenous fistula access flow problems. Material and methods: In 174 patients, 522 radiological investigations and endovascular treatments such as percutaneous transluminal angioplasty were analyzed, retrospectively. All investigations were performed due to clinical suspicion of impaired arteriovenous fistula function. Results: Arterial stenosis was significantly more frequent among patients with diabetic nephropathy (p < 0.001) and interstitial nephritis (p < 0.001). According to the venous stenosis, the diagnosis did not affect the frequency (p = 0.22) or the degree (p = 0.39) of stenosis. The degree of stenosis prior to percutaneous transluminal angioplasty correlated significantly with the degree of remaining stenosis after intervention (p < 0.001). Of the 174 patients, 123 (71%) performed a total of 318 investigations including percutaneous transluminal angioplasty. Repeated percutaneous transluminal angioplasty was performed significantly more often in patients with diabetic nephropathy. The median times to the first percutaneous transluminal angioplasty and to the subsequent percutaneous transluminal angioplasties were 9.5 and 5 months, respectively. Arteriovenous fistula in patients with diabetic nephropathy performed similar to most other diagnoses, although performing more percutaneous transluminal angioplasty/patient than most other diagnoses. Conclusion: Many patients could maintain long-term patency of arteriovenous fistula, including those with diabetic nephropathy, with repeated interventions; this motivates a closer follow-up for these patients. Clinically significant stenosis should be dilated as meticulously and as soon as possible. Occlusions of the arteriovenous fistula in most instances can be successfully thrombolyzed or dilated upon early diagnosis.
Influence of refractive error on pupil diameters in highly myopic eyes with implantable collamer lenses
Authors: Zhu Yi , Yue Yu , Zhu Haobin , Chen Jili , Zhou Jibo 
Published: July 2019

Purpose: To investigate the influence of refractive error on pupil diameters in highly myopic eyes with implantable collamer lenses. Setting: Shanghai, China. Design: A prospective consecutive observational study. Methods: Sixty-six eyes of 66 patients that underwent ICL V4c implantation were included. Pupil diameters before and 1 week, 1 month, and 3 months after surgery were measured using an automatic pupillometry system (MonCv3; Metrovision, Pérenchies, France) under four standardized illumination conditions: 0, 1, 10, and 100 cd/m2. The correlations between changes in pupil diameter and spherical equivalent values and patient age were investigated. Results: Based on preoperative spherical equivalent values, included eyes were divided into a high-myopia group (–6.3 to −9.9 D (diopters)) and a super-high-myopia group (–10 to −20 D). Pupil sizes remained unchanged after surgery in the high-myopia group and decreased at 1 and 10 cd/m2 in the super-high-myopia group. A between-group comparison showed that pupils were significantly smaller in the super-high-myopia group 1 week postoperatively under all illumination conditions and remained smaller at 1 month and 3 months under 1 and 10 cd/m2 lighting conditions. Preoperative spherical equivalent values were significantly correlated with the percent decrease in pupil diameter 1 week postoperatively under 0, 1, and 10 cd/m2 illumination conditions; the greater the degree of myopia, the greater the reduction in pupil diameter. Conclusion: Preoperative refractive error significantly affects pupil diameter in highly myopic eyes after implantable collamer lens implantation. Pupils of super highly myopic eyes remained smaller than preoperative levels under mesopic conditions after implantable collamer lens implantation.
Systematic endobronchial ultrasound-guided transbronchial needle aspiration improves radiotherapy planning in non-small cell lung cancer
Authors: Cole Aidan Joseph , Hardcastle Nicholas , Turgeon Guy-Anne , Thomas Roshini , Irving Louis B. , Jennings Barton R. , Ball David , Kron Tomas , Steinfort Daniel P. , Siva Shankar 
Published: July 2019

ObjectivesPatients suitable for radical chemoradiotherapy for lung cancer routinely have radiotherapy (planning) volumes based on positron emission tomography (PET)-computed tomography (CT) imaging alone. Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) can identify PET-occult malignancy and benign PET-avid regions. We investigated the impact of EBUS-TBNA on curative-intent radiotherapy in non-small cell lung cancer (NSCLC).MethodsA prospective multicentre trial was undertaken, investigating the impact of systematic EBUS-TBNA in addition to PET-CT for patients considered for radical chemoradiotherapy with NSCLC. A subset analysis of patients with discordant findings between PET-CT and EBUS-TBNA was performed. Radiotherapy plans investigated tumour coverage and dose to critical organs at risk (OARs) using PET-CT alone in comparison to PET-CT and EBUS-TBNA.ResultsOf 30 patients enrolled, 10 had discordant findings between PET-CT and EBUS-TBNA. EBUS-TBNA-derived plans allowed for reduction in dose to OARs in patients downstaged by EBUS-TBNA, and reduced the risk of geographic miss in treating PET-occult disease in four patients where EBUS-TBNA identified malignant involvement of PET-negative lymphadenopathy. With the addition of EBUS-TBNA to radiotherapy planning, reductions were noted of 5.7%, 3.7% and 12.5% for the risks of symptomatic pneumonitis, mean heart dose and mean oesophageal dose, respectively.ConclusionsThis study demonstrates for the first time that systematic EBUS-TBNA prior to radical-intent radiotherapy significantly improves coverage of subclinical disease through detection of PET-occult metastases. Identification of false-positive lymph node involvement in highly selected cases may reduce radiation dose to critical structures, and risk of organ toxicity.