bluuebunny/crossref_metadata_2025_split huggingface dataset:
Porous Organic Polymers Containing a Sulfur Skeleton for Visible Light Degradation of Organic Dyes
Authors: Cao Yuping , Liu Wei , Qian Jing , Cao Ting , Wang Jiemin , Qin Wenwu 
Published: June 2019

AbstractThree novel chemically stable porous organic polymers (POPs) were synthesized by the hydrothermal method; the POPs contain sulfone bonds (TpSD), no sulfur atoms (TpMD), or thioether bonds (TpTD). The catalytic mechanism of the POP with sulfone bonds was studied, and it was found that the wide visible light absorption range, high specific surface area, and the hydrophilicity of the material significantly promoted the catalytic efficiency of TpSD. The presence of O=S=O gives TpSD a higher degree of conjugation than TpMD and TpTD, so TpSD shows the strongest UV/Visible absorption and faster transmission of electrons. The photocatalytic degradation of Rhodamine B (RhB) molecules is approximately 100 % with TpSD and its pseudo‐first‐order rate constant is 0.0770 min−1, which is the highest among all reported non‐metallic photocatalysts. Moreover, it is also the first time that sulfur‐containing polymer have been used in photocatalytic degradation of dyes.
Radiation intensity and polarization from accretion disks with progressive increasing height
Authors: Silant'ev Nikolay , Alekseeva G. A. , Novikov V. V. 
Published: June 2019

AbstractThis article considers the optically thick accretion disks with the progressive increasing height. The surface is assumed to be the conical form. The radiation with considered wavelength emerges from a ring on the cone and is described by the Milne problem for the intensity and polarization. The inclination angles of the rings are taken 15 and 30 grad. The inclination angles between the line of sight and the normal to the central accretion disk plane are taken 30, 45, and 60 grad for every value of the ring inclination. For the continuum radiation, the polarization of the emerging light is less than that in the case of the plane accretion disk. The polarization position angles of radiation emerging from the right and left parts of the ring are opposite to one another. They are determined by the geometry of the problem. The position angle of the observed continuum radiation is parallel to the central plane of the accretion disk. Our theory gives the new explanation of that the position angles in “red” and “blue” wings of a spectral line are opposite to one another. This behavior exists in many Seyfert galaxies.
Bile acid changes after metabolic surgery are linked to improvement in insulin sensitivity
Authors: Ahlin S , Cefalo C , Bondia-Pons I , Capristo E , Marini L , Gastaldelli A , Mingrone G , Nolan J J 
Published: June 2019

Abstract

Background
Metabolic surgery is associated with a prompt improvement in insulin resistance, although the mechanism of action remains unknown. The literature on bile acid changes after metabolic surgery is conflicting, and insulin sensitivity is generally assessed by indirect methods. The aim of this study was to investigate the relationship between improvement in insulin sensitivity and concentration of circulating bile acids after biliopancreatic diversion (BPD) and Roux-en-Y gastric bypass (RYGB).

Methods
This was a prospective observational study of nine patients who underwent BPD and six who had RYGB. Inclusion criteria for participation were a BMI in excess of 40 kg/m2, no previous diagnosis of type 2 diabetes and willingness to participate. Exclusion criteria were major endocrine diseases, malignancies and liver cirrhosis. Follow-up visits were carried out after a mean(s.d.) of 185·3(72·9) days. Fasting plasma bile acids were assessed by ultra-high-performance liquid chromatography coupled with a triple quadrupole mass spectrometer, and insulin sensitivity was measured by means of a hyperinsulinaemic–euglycaemic clamp.

Results
A significant increase in all bile acids, as well as an amelioration of insulin sensitivity, was observed after metabolic surgery. An increase in conjugated secondary bile acids was significantly associated with an increase in insulin sensitivity. Only the increase in glycodeoxycholic acid was significantly associated with an increase in insulin sensitivity in analysis of individual conjugated secondary bile acids.

Conclusion
Glycodeoxycholic acid might drive the improved insulin sensitivity after metabolic surgery.
Meta-analysis of the effect of extending the interval after long-course chemoradiotherapy before surgery in locally advanced rectal cancer
Authors: Ryan É J , O'Sullivan D P , Kelly M E , Syed A Z , Neary P C , O'Connell P R , Kavanagh D O , Winter D C , O'Riordan J M 
Published: June 2019

Abstract

Background
The current standard of care in locally advanced rectal cancer (LARC) is neoadjuvant long-course chemoradiotherapy (nCRT) followed by total mesorectal excision (TME). Surgery is conventionally performed approximately 6–8 weeks after nCRT. This study aimed to determine the effect on outcomes of extending this interval.

Methods
A systematic search was performed for studies reporting oncological results that compared the classical interval (less than 8 weeks) from the end of nCRT to TME with a minimum 8-week interval in patients with LARC. The primary endpoint was the rate of pathological complete response (pCR). Secondary endpoints were recurrence-free survival, local recurrence and distant metastasis rates, R0 resection rates, completeness of TME, margin positivity, sphincter preservation, stoma formation, anastomotic leak and other complications. A meta-analysis was performed using the Mantel–Haenszel method.

Results
Twenty-six publications, including four RCTs, with 25 445 patients were identified. A minimum 8-week interval was associated with increased odds of pCR (odds ratio (OR) 1·41, 95 per cent c.i. 1·30 to 1·52; P &lt; 0·001) and tumour downstaging (OR 1·18, 1·05 to 1·32; P = 0·004). R0 resection rates, TME completeness, lymph node yield, sphincter preservation, stoma formation and complication rates were similar between the two groups. The increased rate of pCR translated to reduced distant metastasis (OR 0·71, 0·54 to 0·93; P = 0·01) and overall recurrence (OR 0·76, 0·58 to 0·98; P = 0·04), but not local recurrence (OR 0·83, 0·49 to 1·42; P = 0·50).

Conclusion
A minimum 8-week interval from the end of nCRT to TME increases pCR and downstaging rates, and improves recurrence-free survival without compromising surgical morbidity.
Corporate social responsibility strategy and economic business value of multinational companies in emerging economies: The mediating role of corporate reputation
Authors: Abugre James B. , Anlesinya Alex 
Published: June 2019

AbstractCorporate social responsibility (CSR) and business value of multinational corporations are significantly tied to corporate reputation. In this work, we investigated the mediating influence of corporate reputation of multinational companies (MNCs) on their CSR strategy and economic business value. The study adapted a quantitative methodology with a sample of respondents from multinational corporations in Ghana—an emerging economy. Drawing from 267 employees of MNCs in Ghana, a structural equation modelling and bootstrapping analysis are used to assess the hypothesised relationship. The results showed that CSR strategy positively and significantly predicts economic business value and corporate reputation of MNCs. Findings also showed that corporate reputation mediates the relationship between CSR strategy and economic business value of MNCs operating in emerging economies. This study suggests that good corporate reputation significantly influences MNCs' strategy in corporate responsibility and economic business value. Thus, management of MNCs can enhance their corporate business objectives through sustainability practices.
Human papillomavirus 16E6/E7 activates autophagy via Atg9B and LAMP1 in cervical cancer cells
Authors: Tingting Chen , Shizhou Yang , Songfa Zhang , Junfen Xu , Weiguo Lu , Xiaodong Cheng , Xing Xie 
Published: June 2019

AbstractBackgroundsAlthough the role of high‐risk human papillomavirus (HPV) E6 and E7 in cellular malignant transformation has been elucidated， the function of both genes in cellular homeostasis is still unknown. Autophagy functions in maintenance of cellular homeostasis play a key role in the initiation and development of cancer and infectious disease.MethodsCervical cancer cell lines SiHa and CaSki were utilized in this study.ResultsWe found that HPV 16E6/E7 (16E6/E7) downregulation inhibited autophagy, and consequently suppressed cell proliferation and promoted early apoptosis. Transcriptome sequencing demonstrated that Atg9B and LAMP1 were downregulated in 16E6/E7 knockdown cells. Gene function experiments revealed that 16E6/E7 downregulation depressed Atg9B and LAMP1, and Atg9B and LAMP1 overexpression compensated, at least partially, autophagy blockage induced by 16E6/E7 knockdown. Immunoprecipitation assay showed that 16E7 interacted with Atg9B and dual‐luciferase reporter system revealed that 16E6 most likely regulated −1750 to −2000 nt in Atg9B and −1800 to −2000 nt in LAMP1 promoter region.ConclusionsOur findings verified that 16E6/E7 activated autophagy via accelerating autophagosome formation and degradation, and Atg9B and LAMP1 were involved in the process of 16E6/E7 modulating autophagy, suggesting that targeting autophagy may be a potential approach in cervical cancer therapeutics.
Survival analysis and sentinel lymph node status in thin cutaneous melanoma: A multicenter observational study
Authors: Tejera‐Vaquerizo Antonio , Ribero Simone , Puig Susana , Boada Aram , Paradela Sabela , Moreno‐Ramírez David , Cañueto Javier , de Unamuno Blanca , Brinca Ana , Descalzo‐Gallego Miguel A. , Osella‐Abate Simona , Cassoni Paola , Carrera Cristina , Vidal‐Sicart Sergi , Bennássar Antoni , Rull Ramón , Alos Llucìa , Requena Celia , Bolumar Isidro , Traves Víctor , Pla Ángel , Fernández‐Orland A. , Jaka Ane , Fernández‐Figueres María T. , Hilari Josep M. , Giménez‐Xavier Pol , Vieira Ricardo , Botella‐Estrada Rafael , Román‐Curto Concepción , Ferrándiz Lara , Iglesias‐Pena Nicolás , Ferrándiz Carlos , Malvehy Josep , Quaglino Pietro , Nagore Eduardo ,   on behalf of SENTIMEL group
Published: June 2019

AbstractMitotic rate is no longer considered a staging criterion for thin melanoma in the 8th edition of the American Joint Committee on Cancer Staging Manual. The aim of this observational study was to identify prognostic factors for thin melanoma and predictors and prognostic significance of sentinel lymph node (SLN) involvement in a large multicenter cohort of patients with melanoma from nine tertiary care hospitals. A total of 4249 consecutive patients with thin melanoma diagnosed from January 1, 1998 to December 31, 2016 were included. The main outcomes were disease‐free interval and melanoma‐specific survival for the overall population and predictors of SLN metastasis (n = 1083). Associations between survival and SLN status and different clinical and pathologic variables (sex, age, tumor location, mitosis, ulceration, regression, lymphovascular invasion, histologic subtype, Clark level, and Breslow thickness) were analyzed by Cox proportional hazards regression and logistic regression. SLN status was the most important prognostic factor for melanoma‐specific survival (hazard ratio, 13.8; 95% CI, 6.1‐31.2; P < 0.001), followed by sex, ulceration, and Clark level for patients who underwent SLNB. A mitotic rate of >2 mitoses/mm2 was the only factor associated with a positive SLN biopsy (odds ratio, 2.9; 95% CI, 1.22‐7; P = 0.01. SLN status is the most important prognostic factor in thin melanoma. A high mitotic rate is associated with metastatic SLN involvement. SLN biopsy should be discussed and recommended in patients with thin melanoma and a high mitotic rate.
Time‐Effective Accelerated Cyclic Aging Analysis of Lithium‐Ion Batteries
Authors: Agyei Appiah Williams , Park Joonam , Byun Seoungwoo , Roh Youngjoon , Ryou Myung‐Hyun , Lee Yong Min 
Published: June 2019

AbstractWe propose a time‐effective framework for accelerated cyclic aging analysis of lithium‐ion batteries. The proposed framework involves the coupling of a physico‐chemical capacity‐fade model that considers the cyclic aging mechanisms of the LiMn2O4/graphite cell, with a physics‐based porous‐composite electrode model to predict cycling performance at different temperatures. A one‐dimensional simple empirical life model is then developed from the coupled physico‐chemical capacity‐fade model and the physics‐based porous‐composite electrode model predictions. An accelerated cyclic aging analysis based on the principle of time‐temperature superposition is performed using the developed one‐dimensional simple life empirical model. The proposed framework is used to predict the maximum number of cycles and the highest temperature required for accelerated cyclic aging analysis of LiMn2O4/graphite cells. The efficacy of the proposed framework is validated with experimental cycle‐performance data obtained from LiMn2O4/graphite coin cells at 25 and 60 °C.
Chemical Mass Production of MoS2/Graphene van der Waals Heterostructure as a High‐Performance Li‐ion Intercalation Host
Authors: Gong Shan , Zhao Guangyu , Zhang Naiqing , Sun Kening 
Published: June 2019

AbstractTwo‐dimensional (2D) heterostructured materials, combining the desired advantages of individual 2D materials and eliminating the associated shortcomings, have inspired great interest in electrochemical energy storage applications. But searching a highly efficient and practical method for preparing 2D heterostructures as electrode materials is still challenging. Herein, a 2D MoS2/graphene (GR) heterostructure is synthesized through a facile and accessible self‐assembly method, which includes adsorbing ammonium thiomolybdate onto graphene oxide (GO) surface via electrostatic attraction and subsequently annealing the precursor to heterostructure. A high loading amount (86.2 %) of unilaminar MoS2 nanosheets lie on the GR sheets forming a face‐to‐face structure, and the MoS2 nanosheets exhibit a largely expanded interlayer spacing (1.0–1.2 nm) resulting from the alternately stacked structure during self‐assembly process. As a Li‐ion intercalation host, this unique MoS2/GR heterostructure exhibits pseudocapacitance‐dominated characteristics with superior kinetic performances and extremely high structural stability. These characteristics afford MoS2/GR heterostructure remarkable rate capability (155.6 mAh g−1 at 4 A g−1; 119.3 mAh g−1 at 16 A g−1) and a durable reversible capacity (over 5000 cycles). This method is suitable for mass production of MoS2/GR heterostructure and paves a way for utilizing 2D heterostructured materials in Li‐ion or other metal ion batteries.
Support‐Free Pd3Co NCs as an Efficient Heterogeneous Nanocatalyst for New Organic Transformations of C−C Coupling Reactions
Authors: Pradhan Samjhana , Mishra Kanchan , Lee Yong Rok 
Published: June 2019

AbstractA support‐free heterogeneous Pd3Co nanostructured composite (NC), synthesized through a hydrothermal route, acted as an effective catalytic system in multivariate Heck‐, Sonogashira‐, and Suzuki‐type coupling reactions of iodonium ylides. The XPS analysis of the bimetallic Pd3Co NCs confirmed the elemental composition as 75 % palladium and 25 % cobalt. Furthermore, high‐resolution (HR) TEM analysis confirmed the spherical morphology of the Pd3Co bimetallic nanoparticles. The average diameter of the NCs is 14.8 nm. The coupling reaction proceeded through the generation of α‐iodoenones with simultaneous migration of the phenyl group, thereby giving a scaffold with higher atom economy. The heterogeneous Pd3Co NCs were recycled and reused without any significant change in catalytic ability for up to five reaction cycles. The high concentration of Pd and association of cobalt into the lattice of palladium appears to enhance its catalytic ability for the diverse coupling reactions in comparison with its monometallic counterparts as well as with bimetallic NCs with a comparatively lesser amount of Pd.
Directing Traffic: Halogen‐Bond‐Mediated Membrane Transport
Authors: Govindaraj Vijayakumar , Ungati Harinarayana , Jakka Surendar R. , Bose Sritama , Mugesh Govindasamy 
Published: June 2019

AbstractThe plasma membrane regulates the transport of molecules into the cell. Small hydrophobic molecules can diffuse directly across the lipid bilayer. However, larger molecules require specific transporters for their entry into the cell. Regulating the cellular entry of small molecules and proteins is a challenging task. The introduction of halogen, particularly iodine, to small molecules and proteins is emerging to be a promising strategy to improve the cellular uptake. Recent studies reveal that a simple substitution of hydrogen atom with iodine not only increases the cellular uptake, but also regulates the membrane transport. The strong halogen‐bond‐forming ability of iodine atoms plays a crucial role in the transport and the introduction of iodine may provide an efficient strategy for studying membrane activity and cellular functions and improving the delivery of therapeutic agents. This Concept article does not provide a comprehensive picture of membrane transport but highlights halogen‐substitution as a novel strategy for understanding and regulating the cell‐membrane traffic.
Benzyl Borane NHC Adducts: Beyond B−C Bond Scission
Authors: Böser Richard , Denker Lars , Frank René 
Published: June 2019

AbstractBenzyl‐substituted boronates and borates are widely employed as mild sources in radical or anionic transfer reactions of benzyl entities. In this process the B−C bond to the benzyl moiety is essentially ruptured. In contrast, reactions with retention of the B−C bond are poorly investigated although several other reactive sites in benzyl–boron systems are clearly inherent. In this respect, the novel reactivity of the representative borane adduct IiPr−BH2Bn [IiPr=:C{N(iPr)CH}2, Bn=CH2C6H5] is demonstrated. Dihalogenation of the BH2 entity is observed with BCl3 and BBr3, whereas BI3 either affords IiPr−BHI2 or proceeds with borylation of the aromatic phenyl ring to give a hydride‐bridged bisborylated species. The photochemical mono‐ and dihalogenation of the benzylic CH2 group was demonstrated with elemental bromine Br2. The brominated product IiPr−BBr2−CHBr−C6H5 was borylated at the benzylic carbon atom in an umpolung event with BI3 to afford the zwitterion IiPr−BI−CH(BI3)−C6H5.
Asymmetric Synthesis of Biaryl Atropisomers Using an Organocatalyst‐Mediated Domino Reaction as the Key Step
Authors: Hayashi Yujiro , Takikawa Akira , Koshino Seitaro , Ishida Keiichi 
Published: June 2019

AbstractA three‐pot synthetic method that features the use of an organocatalyst as the key step was developed for the preparation of biaryl atropisomers. The first reaction is an asymmetric domino Michael–Henry reaction catalyzed by diphenylprolinol silyl ether to afford the substituted nitrocyclohexanecarbaldehyde with four stereogenic centers and one defined configuration of a stereogenic axis with excellent enantioselectivity. Removal of the central chirality from the domino products afforded biaryl atropisomers having axial chirality with excellent enantioselectivity.
Copula‐based semiparametric analysis for time series data with detection limits
Authors: Li Fuyuan , Tang Yanlin , Wang Huixia Judy 
Published: June 2019

AbstractThe analysis of time series data with detection limits is challenging due to the high‐dimensional integral involved in the likelihood. Existing methods are either computationally demanding or rely on restrictive parametric distributional assumptions. We propose a semiparametric approach, where the temporal dependence is captured by parametric copula, while the marginal distribution is estimated non‐parametrically. Utilizing the properties of copulas, we develop a new copula‐based sequential sampling algorithm, which provides a convenient way to calculate the censored likelihood. Even without full parametric distributional assumptions, the proposed method still allows us to efficiently compute the conditional quantiles of the censored response at a future time point, and thus construct both point and interval predictions. We establish the asymptotic properties of the proposed pseudo maximum likelihood estimator, and demonstrate through simulation and the analysis of a water quality data that the proposed method is more flexible and leads to more accurate predictions than Gaussian‐based methods for non‐normal data. The Canadian Journal of Statistics 47: 438–454; 2019 © 2019 Statistical Society of Canada
Toward a knowledge model focusing on microservices and cloud computing
Authors: Apel Sebastian , Hertrampf Florian , Späthe Steffen 
Published: June 2019

SummaryMicroservices tend to use a variety of tools to create a well‐defined process of building, packing, backing, and publishing. These tools are usually configured independently by their descriptors. Interrelations between the different tools arise implicitly, but the overall structure only works if the different configurations are correctly coordinated along each other. This paper motivates the development of a knowledge model via a microservice measurement infrastructure within the research project WINNER, which explicitly shapes these interrelationships. For the development of our infrastructure‐related work, experience and requirements of currently common tools are used as a basis. The model contains essential structures for the description of configurations and endpoints, artefacts, and connections for the creation as well as publication process of services result. Our results are applied and discussed in an example.
Assessing the determinants of performance in the recycling business: Evidence from the Italian context
Authors: Franceschelli Maria Vittoria , Santoro Gabriele , Giacosa Elisa , Quaglia Roberto 
Published: June 2019

AbstractThis study aims to shed light on the elements that can influence the performance of green businesses, more specifically organizations active within the recycling business. After defining and identifying green businesses, the paper focuses on the Italian recycling business, examining whether the green practices and features of a green business can influence the organization's performance. Using a quantitative methodology with a sample of 87 Italian organizations whose core business is recycling and applying a model of multiple linear regression, the findings highlight several variables that affect the economic results. The originality of this study lies in the link between green practices and green businesses, exploring which structures are efficient and are driving elements of these recycling organizations. These findings offer several contributions to theory and practice and for policymakers.
Sustainable business model innovation and acceptance of its practices among Spanish entrepreneurs
Authors: Peralta Alberto , Carrillo‐Hermosilla Javier , Crecente Fernando 
Published: June 2019

AbstractSustainable business model innovation debate is mostly focusing on the use of certain practices and tools to implement sustainable objectives in new firms. Our paper contributes to this debate examining the factors influencing the entrepreneur's election of the practices to develop sustainable business model innovation (SBMI). We conducted an empirical analysis on a population of Spanish entrepreneurs (N = 234) and applied a sound behavioral framework and the PLS‐SEM algorithms to factor out those elements. On the basis of this analysis, we argue that performance expectancy, effort expectancy, social influence, facilitating conditions, hedonic motivation, habit, costs, speed, funding, and security and behavioral intention might affect the entrepreneurial acceptance of the practices leading to SBMI. We also argue that the knowledge of these factors benefit incubators, mentors, and agencies balance them into their support to sustainable business development. Our analyses open a novel research line by studying those factors influencing entrepreneurial use of sustainable innovation practices and facilitating future development of full‐scale models explaining this usage.