bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ocular in situ gel: An overview
Authors: Majeed Asmat , Khan Nisar Ahmad 
Published: January 2019

Eye is the most sensitive organ of the body. Designing of ocular drug delivery system is the most challenging field for pharmaceutical scientists as less than 5% of administered drug enters the eye due to the complicated anatomical structure of the eye, small absorptive surface and low transparency of the cornea, lipophilicity of corneal epithelium, pre corneal loss (due to nasolacrimal drainage), bonding of the drug with proteins contained in tear fluid, blinking, low capacity of conjunctival sac, that restricts the entry of drug molecule at the site of action and ultimately leads to poor ocular therapy. To improve ophthalmic drug bioavailability, there are considerable efforts directed towards newer drug delivery systems for ophthalmic administration. These novel drug delivery systems offer manifold advantages over conventional systems as they increase the efficiency of drug delivery by improving the release profile and also reduce drug toxicity. A lot of research going on in this area proves the fact that in situ gelling systems can be beneficial in the ocular drug delivery. In situ gel forming systems are drug delivery systems that are in solution form before administration in the body but once administered, undergo in situ gelation, to form a gel triggered by external stimulus such as temperature, pH etc. This review is to Specify a brief summary about in situ gels, various approaches for in situ gelling systems, different types of polymers used in in situ gels, their mechanisms of gel formation and evaluation of polymeric in situ gel.
Keywords: in situ gel, polymers, Temperature induced in situ gel system, pH induced in situ gel system, Ion activated systems.
Formulation and evaluation of sustain released matrix tablet of atenolol
Authors: Sahu Sonal , Dangi Rohit , Patidar Rohit , Rukhsaar , , Rathi Jagdish , Asati Vivek 
Published: January 2019

Oral route is one of the most popular routes of drug delivery due to its ease of administration, patient compliance, least sterility constraints and flexible design of dosage form. The aim of present investigation was to develop matrix tablets of atenolol using different polymers. Atenolol matrix tablets were prepared by direct compression and wet granulation method using different polymers. All the formulations were evaluated for weight variation, thickness, hardness, friability and dissolution. Tablets of atenolol were prepared utilizing natural polymer chitosan. The formulation F-2 contained chitosan which might have sustained the release since it is also known for its polymeric sustaining effect. The formulation F-2 gave 89.57±0.24% of the drug release in 12 hrs of study.
Keywords: Atenolol, Sustained release Matrix tablets, Direct compression, Wet granulation method.
Evaluation of Antidepressant Activity of Ethanolic Extract of Abies webbiana and Berberis aristata in Laboratory Animals
Authors: Gautam Sucheta , Sachan Neetu , Shrivastav Alankar , Pal Dilipkumar 
Published: January 2019

Abstract
Objective: Abies webbiana and Berberis aristata is an herbal plant that has several therapeutic effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated anti-depressant effect of ethanolic extract from Abies webbiana and Berberis aristata by using Forced Swimming Test (FST) and Tail Suspension Test (TST).
Methods: Two doses of ethanolic extract of Abies webbiana and berberis aristata (200 mg/kg and 400 mg/kg) was given orally. Immobility time were measured after 30 min after the dosing and compared with control group and Flouxetine (25mg/kg) as a standard group.
Results: The ethanolic extract of BA and AW (400 mg/kg) was found to be effective and it exhibited activity similar to that of the conventional drug Flouxetine (25mg/kg) (p<0.001) whereas 200 mg/kg dose showed higher activity with significantly increased swimming time and suspension time and decreased immobility time than 400 mg/kg of ethanolic extracts and Flouxetine (25mg/kg).
Conclusion: These results proposed 400 mg/kg of ethanolic extract was showed higher anti-depressant activity as compared to control which is similar to the standard.
PEMBUATAN MESIN SCREW CONVEYOR UNTUK PENCAMPURAN GARAM DAN IODIUM SESUAI SNI 3556
Authors: Rofeg Aenor , Khabib Masruki , Winarso Rochmad 
Published: January 2019

Pada proses pencampuran garam dan iodium pada industri umumnya menggunakan proses manual dengan mengaduk di meja atau sejenis cangkul yang mengakibatkan kurang maksimalnya kualitas garam beriodium SNI dan dibutuhkan waktu yang kurang efisien yang bergantung pada tenaga manusia yang cenderung semakin berkurang ketika semakin banyak tenaga di keluarkan. Tujuan dari penelitian ini adalah membuat mesin screw conveyor untuk pencampuran garam dan Iodium sesuai dengan SNI 3556 dengan kapasitas 1400 kg/jam yang mampu mencampur garam yang beriodium secara Homogen menggunakan system Screw Conveyor. Tahap pembuatan mesin mencakup pekerjaan: gambar kerja, pemotongan bahan sesuai gambar, pembubutan, pengelasan, perakitan dan uji untuk kerja mesin untuk mengetahui hasil pembuatan mesin. Hasil yang dicapai adalah membuat Mesin Screw Conveyor Untuk Pencampuran Garam dan Iodium Sesuai Dengan SNI 3556 dengan kapasitas 1500 kg/jam yang homogen (minimal 30 ppm). Konstruksi mesin ini cukup sederhana terdiri dari Ribbon (Screw), bearing, V-Belt, puli, elektro motor serta murah dan mudah dalam pengoperasianya
PENANGGULANGAN BENCANA OLEH ORGANISASI LOKAL DI KECAMATAN JATINANGOR
Authors: Fedryansyah Muhammad , Pancasilawan Ramdhan , Ishartono Ishartono 
Published: January 2019

Perubahan paradigma mendorong peran serta dari masyarakat untuk terlibat menjadi aktor utama dalam setiap aktivitas penanggulangan bencana. Bentuk dari keterlibatan masyarakat dalam penanggulangan bencana terdapat di Kecamatan Jatinangor, Kabupaten Sumedang melalui organisasi lokal yaitu Jatinangor Emergency Responcse Community (Jersey).Penelitian ini bertujuan untuk menggambarkan peran organisasi lokal dalam penanggulangan bencana di Kecamatan Jatinangor. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan melakukan analisis berdasarkan interpretasi dari data primer maupun sekunder. Penelitian ini juga melibatkan 20 orang informan sebagai sumber data primer.Hasil penelitian diketahui bahwa dalam siklus penanggulangan bencana, yaitu tahap pra bencana, saat bencana, dan pasca bencana, Jatinangor Emergency Response Community melakukan tindakan pencegahan, peringatan dini, water rescue, pemberian bantuan logistik dan pemulihan kondisi lingkungan yang terdampak bencana.
STRATEGI TANGGUNG JAWAB SOSIAL PERUSAHAAN (CSR) PT PERTAMINA MELALUI PROGRAM KEMITRAAN DAN BINA LINGKUNGAN DALAM PERTAMINA SEHATI
Authors: Tsamara Yumna Nurtanty , Raharjo Santoso Tri , Resnawaty Risna 
Published: January 2019

ABSTRAK Pelaksanaan tanggung jawab sosial perusahaan (Corporate Social Responsibility/CSR) memiliki tujuan utama untuk memastikan bahwa kepentingan sosial dari berbagai kelompok pemangku kepentingan dapat dipenuhi secara tepat dan proporsional, terutama masyarakat yang berada di sekitar lingkungan kerja perusahaan. Pertamina Sehat Anak Tercinta dan Ibu (Sehati) merupakan program ikonik Pertamina dalam upaya meningkatkan tingkat kesehatan ibu dan anak. Dalam konteks implementasi Sustainable Development Goals (SDGs) 2016, Pertamina Sehati berupaya untuk mencapai 2 tujuan, yaitu meningkatkan kesehatan ibu dan menurunkan angka kematian anak. Melalui program ini, Pertamina berkontribusi dalam upaya peningkatan gizi balita dan penurunan angka kematian ibu, bayi dan balita menuju kehidupan yang lebih baik. Dalam pelaksanaannya, Pertamina bekerja sama dengan Perkumpulan Keluarga Berencana Indonesia (PKBI). Pertamina mengelola program ini melalui fungsi CSR yang berfungsi sebagai inisiator dan pengawas program serta penyedia dana dan anggaran dana. Sementara itu, PKBI sebagai mitra kerja berperan sebagai pendamping program dan fasilitator. ABSTRACThe implementation of Corporate Social Responsibility (CSR) has the main objective of ensuring that the social interests of various groups of stakeholders can be fulfilled appropriately and proportionally, especially the people who are around the company's work environment. Pertamina Healthy Beloved and Mother Children (Sehati) is Pertamina's iconic program in an effort to improve maternal and child health levels. In the context of the implementation of the 2016 Sustainable Development Goals (SDGs), Pertamina Sehati seeks to achieve two objectives, namely improving maternal health and reducing child mortality. Through this program, Pertamina contributes to efforts to improve toddler nutrition and reduce maternal, infant and under-five mortality to a better life. In its implementation, Pertamina cooperates with the Indonesian Family Planning Association (PKBI). Pertamina manages this program through the CSR function that functions as the program initiator and supervisor and provider of funds and budget funds. Meanwhile, PKBI as a working partner acts as a program facilitator and facilitator.
Data Mining Techniques as a Tool in Neurological Disorders Diagnosis
Authors: Zdrodowska Małgorzata , Dardzińska Agnieszka , Chorąży Monika , Kułakowska Alina 
Published: January 2019

Abstract
Neurological disorders are diseases of the brain, spine and the nerves that connect them. There are more than 600 diseases of the nervous system, such as epilepsy, Parkinson's disease, brain tumors, and stroke as well as less familiar ones such as multiple sclerosis or frontotemporal dementia. The increasing capabilities of neurotechnologies are generating massive volumes of complex data at a rapid pace. Evaluating and diagnosing disorders of the nervous system is a complicated and complex task. Many of the same or similar symptoms happen in different combinations among the different disorders. This paper provides a survey of developed selected data mining methods in the area of neurological diseases diagnosis. This review will help experts to gain an understanding of how data mining techniques can assist them in neurological diseases diagnosis and patients treatment.
Modeling and Operational Analysis of an Automotive Shock Absorber with a Tuned Mass Damper
Authors: Sikora Marian 
Published: January 2019

Abstract
Recently, the topic of energy dissipation efficiency of vehicle suspension dampers has become a research and engineering problem due to structural requirements of vehicle manufacturers and the introduction of electric/hybrid cars. By principle, any disturbances in the damping force generation process translate into pressure fluctuations to be then transferred to the body of the vehicle. The effect known as rattling within the damper engineering community is perceived as detrimental to ride comfort. To improve the performance of a vehicle damper several methods can be devised and used. One approach is to optimize the settings of the valves in the damper. The approach, however, often influences the force output of the damper. Another technique involves the application of add-on systems. One such system is the tuned mass damper concept originally developed by Frahm for structural engineering applications. In the paper the author proposes a damper concept equipped with an external/internal tuned mass damper component for improving the dynamic characteristics of vehicle dampers. The author presents modeling details followed by simulations of the damper with the tuned mass damper concept subjected to oscillatory inputs, and a critical analysis of the presented results.
The mediation effect of Perceived Social Support and Perceived Stress on the relationship between Emotional Intelligence and Psychological Wellbeing in Male Athletes
Authors: Malinauskas Romualdas , Malinauskiene Vilija 
Published: January 2019

Abstract
This study aimed to examine the relationship between emotional intelligence (EI) and psychological wellbeing in a three-month follow-up study of male athletes. In addition, we examined the mediating role of perceived social support and perceived stress on the relationship between EI and psychological wellbeing. The sample included 398 male athletes who completed measures of emotional intelligence (Schutte Self-Report Inventory), psychological wellbeing (Ryff Psychological Wellbeing Scale; SSRI), perceived social support (Multidimensional Scale of Perceived Social Support), and perceived stress (Perceived Stress Scale–10). Results from structural equation modelling procedures identified that perceived social support and perceived stress partially mediated the association between EI and psychological wellbeing. The sequential mediation effects of perceived social support–perceived stress on the relations between EI and wellbeing were confirmed. Finally, limitations and recommendations for future research were considered
Post‐Activation Potentiation Increases Recruitment of Fast Twitch Fibers: A Potential Practical Application in Runners
Authors: Gervasi Marco , Calavalle Anna Rita , Amatori Stefano , Grassi Eugenio , Benelli Piero , Sestili Piero , Sisti Davide 
Published: January 2019

Abstract
To determine the relationship between fatigue and post-activation potentiation, we examined the effects of sub-maximal continuous running on neuromuscular function tests, as well as on the squat jump and counter movement jump in endurance athletes. The height of the squat jump and counter movement jump and the estimate of the fast twitch fiber recruiting capabilities were assessed in seven male middle distance runners before and after 40 min of continuous running at an intensity corresponding to the individual lactate threshold. The same test was then repeated after three weeks of specific aerobic training. Since the three variables were strongly correlated, only the estimate of the fast twitch fiber was considered for the results. The subjects showed a significant improvement in the fast twitch fiber recruitment percentage after the 40 min run. Our data show that submaximal physical exercise determined a change in fast twitch muscle fiber recruitment patterns observed when subjects performed vertical jumps; however, this recruitment capacity was proportional to the subjects’ individual fast twitch muscle fiber profiles measured before the 40 min run. The results of the jump tests did not change significantly after the three-week training period. These results suggest that pre-fatigue methods, through sub-maximal exercises, could be used to take advantage of explosive capacity in middle-distance runners.
Relative Age Effect and Long-Term Success in the Spanish Soccer and Basketball National Teams
Authors: López de Subijana Cristina , Lorenzo Jorge 
Published: January 2019

Abstract
The aims of this study were: i) to analyze whether relative age effect occurs in the athletes of the junior national teams and professional athletes in Spain in general and in soccer and basketball, and ii) to compare the long-term success of the players selected for the junior national team between these sports. The samples for this study were Spanish professional soccer (n = 461) and basketball (n = 250) players in the 2013-2014 premier league and players from the junior Spanish soccer (i.e., n = 273; U-17: n = 107; U-19: n = 166) and basketball (i.e., n = 240; U-18: n = 120, U-16: n = 120) teams that classified to play in the European Championships (from 2004 to 2013). Junior players (42.3%) were more frequently born in the 1st quarter of the year than the professional players (30.7%) (χ2(3) = 30.07; p = .001; Vc = .157). This was found in both basketball (χ2(3) = 12.2.; p = .007; Vc = .158) and soccer (χ2(3) = 20.13; p < .001; Vc = .166). Long-term success is more frequent in soccer, where 59.9% of the juniors selected for the national team played later in the premier league, while in basketball that percentage was 39.6% (χ2(1) = 14.64; p < .001; Vc = .201). On the other hand, 79.4% and 39.8% of the professional soccer and basketball players had been previously selected for junior national teams (χ2(1) = 60.2; p < .001; Vc = .386), respectively. The talent selection process should be reviewed as players born in the second half of the year have fewer opportunities to stand out.
Intra and Interzone Differences of Attack and Counterattack Efficiency in Elite Male Volleyball
Authors: Grgantov Zoran , Jelaska Igor , Šuker Dragutin 
Published: January 2019

Abstract
The primary goal of this study was to identify and explain differences in a volleyball set between winning and defeated teams, based on frequency and efficiency of the attack and counterattack, both overall and from particular zones of the volleyball court. Research was conducted on a randomly chosen sample of 206 sets played in 55 matches of the Men's Champions League. A total of 10555 spikes in the attack and counterattack from various zones of the volleyball court were analyzed. Between-subjects 2×5 factorial ANOVA (Outcome×Zone) was used to identify significant differences between the set outcome and zones or their interaction for both attack and counterattack efficiency. Significant differences were found in the efficiency of spikes in attacks and counterattacks from various zones of the volleyball court and between winning and losing teams. Post-hoc analysis of interaction effects also revealed significant differences. The obtained results substantiate the importance of spiking, both in the attack and counterattack, for winning a volleyball set, and indicate the specific values of spiking in the attack and counterattack from various zones, for both winning and defeated teams. The results of this study can be useful for coaches, in evaluation of player's performance in the match, in planning and programming the training process as well as in the technical and tactical preparation of the team for the tournament.
Training Loads and RSA and Aerobic Performance Changes During the Preseason in Youth Soccer Squads
Authors: Cetolin Tiago , Teixeira Anderson Santiago , Netto Almir Schmitt , Haupenthal Alessandro , Nakamura Fábio Yuzo , Guglielmo Luiz Guilherme Antonacci , Silva Juliano Fernandes da 
Published: January 2019

Abstract
The aims of this study were to compare the internal training load (ITL) in soccer players of two competitive age groups (under-15 [U-15] and under-19 [U-19]) during an 8-week preseason training period and compare the associated changes in physical performance measures. Eighteen U-15 and twelve U-19 players were monitored over an 8-week period during the preseason phase. The ITL was monitored using the session rating of perceived exertion (RPE) method. Before and after the preseason period, physical performance was assessed by best (RSAbest) and mean (RSAmean) times in a repeated sprint ability (RSA) test and peak velocity derived from the Carminatti test (PVT-CAR). Total weekly ITL increased with age (U-15: 13770 ± 874 AU vs. U-19: 33584 ± 2506 AU; p < 0.001). In addition, U-19 players perceived training sessions as heavier than U-15 players (6.1 ± 0.3 vs. 5.3 ± 0.3 AU, respectively; p < 0.001). After the preseason period, very likely to almost certainly positive changes were observed for all performance measures in both age groups. However, the U-15 group had possibly superior gains in RSAbest (+1.40%, 90%CL -0.29 to 3.05, with ES = 0.35) and likely higher effects in RSAmean (+1.89%, 90%CL 0.04 to 3.70, with ES = 0.53) and PVT-CAR (+2.71%, 90%CL 0.35 to 5.01, with ES = 0.37) compared to the U-19 group. In conclusion, our findings demonstrate that the U-19 group accumulate higher total weekly ITLs than the U-15 group during the preseason phase due to longer and heavier training sessions. However, the U-15 group obtained superior gains in soccer-specific physical abilities while accumulating half the total ITLs during lighter training sessions.
Test-Retest Reliability of Isokinetic Arm Strength Measurements in Competitive Swimmers
Authors: Collado-Mateo Daniel , Dominguez-Muñoz Francisco J. , Batalha Nuno , Parraça Jose , Tomas-Carus Pablo , Adsuar Jose C. 
Published: January 2019

Abstract
Swimming motor patterns lead internal rotators to grow stronger than antagonist muscles, what may increase the risk of injury in swimmers. Injury prevention often involves the improvement of external rotators strength, as well as the external rotation/internal rotation ratio. The current research aimed to evaluate the test-retest reliability of shoulder concentric rotation strength in competitive swimmers using an isokinetic dynamometer. The study enrolled 35 competitive swimmers aged between 13 and 19 years. Concentric movements were performed including internal and external rotations of the shoulder joint following the instructions of the standardized protocol. The angular velocity of the test was defined at 60º/s. Outcome measures were peak torque (Nm) and work (J), measured in both, the dominant and non-dominant arms. The external rotation/internal rotation ratio was also calculated. Reliability was excellent for peak torque and work. For the external rotation/internal rotation ratio, the ICC oscillated between 0.744 and 0.860 for the work ratio of the non-dominant arm and the peak torque ratio of the dominant arm, respectively. In general terms, better reliability was observed for peak torque compared with work, for external rotation compared with internal rotation, and for the dominant arm compared with the non-dominant one.
Pulmonary Rehabilitation with a Stabilometric Platform After Thoracic Surgery: A Preliminary Report
Authors: Jastrzębski Dariusz , Żebrowska Aleksandra , Rutkowski Sebastian , Rutkowska Anna , Warzecha Joanna , Ziaja Bettina , Pałka Aleksandra , Czyżewska Barbara , Czyżewski Damian , Ziora Dariusz 
Published: January 2019

Abstract
The aim of this study was to evaluate the influence of exercises on a stabilometric platform on the physical fitness and mobility of patients with lung cancer after thoracic surgery. The Experimental Group included 22, and the Control Group consisted of 21 patients. All included patients were enrolled after thoracic surgery due to lung cancer. The Experimental and Control Groups were enrolled in a 3-week in-hospital pulmonary rehabilitation program. The Experimental Group additionally performed daily 20-min training sessions on a stabilometric platform. Agility and flexibility were assessed with the Fullerton test before and after rehabilitation in both groups, and quality of life was assessed with the SF-36 questionnaire. Exercise performance stated as a distance in a 6 min walking test (6MWT) significantly improved in both groups with a medium effect size. The results of the Fullerton test indicated improvements in flexibility in both groups after the completion of the program without a significant difference between the groups and with a small effect size. In the Experimental Group, the best results were observed in the Arm curl (p = 0.0001), Chair stand (p = 0.04), Up and go (p = 0.001) and Chair sit and reach (p = 0.0001) tasks. No deterioration in the quality of life was observed in the Experimental or the Control Group after the completion of the program. Between-group analyses revealed significant differences in the Role-Physical (RP) (p = 0.020) and Mental-Health (MH) (p = 0.025) domains of the SF-36. The rehabilitation program with a stabilometric platform improved agility and flexibility of patients after thoracic surgery without an effect size or significant differences between the Experimental and Control Groups.