bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological and epidemiological significance of breast cancer subtype reclassification based on p53 immunohistochemical expression
Authors: Abubakar Mustapha , Guo Changyuan , Koka Hela , Sung Hyuna , Shao Nan , Guida Jennifer , Deng Joseph , Li Mengjie , Hu Nan , Zhou Bin , Lu Ning , Yang Xiaohong R. 
Published: July 2019

AbstractTP53 mutations are common in breast cancer and are typically associated with more aggressive tumor characteristics, but little is known about the clinicopathological and epidemiological relevance of p53 protein expression, a TP53 mutation surrogate, in breast cancer subtypes. In this study of 7226 Chinese women with invasive breast cancer, we defined breast cancer subtypes using immunohistochemical (IHC) measures of hormone receptors and HER2 in conjunction with histologic grade. p53 expression status was then used to further stratify subtypes into p53-positive and p53-negative. Odds ratios (ORs) and 95% confidence intervals (CIs) in case-only logistic regression analyses were used to examine heterogeneity across different subtypes. The frequency of p53 protein expression varied by breast cancer subtype, being lowest in the luminal A-like and highest in the triple-negative and HER2-enriched subtypes (P-value < 0.01). In luminal A-like and B-like/HER2-negative subtypes, p53 positivity was associated with early-onset tumors, high grade, high proliferative index, and basal marker (CK5/6 and EGFR) expression. Further, compared with luminal A-like/p53-negative patients, A-like/p53-positive patients were more likely to be parous [adjusted OR parous vs. nulliparous = 2.67 (1.60, 4.51); P-value < 0.01] and to have breastfed [adjusted OR ever vs. never = 1.38 (1.03, 1.85); P-value = 0.03]. p53 positivity was not associated with examined clinical and risk factors in other tumor subtypes. Overall, these findings suggest that p53 expression, which is readily available in many settings, can be used to identify phenotypes of luminal A-like breast cancer with distinct clinical and epidemiological implications.
Serum sLYVE-1 is not associated with coronary disease but with renal dysfunction: a retrospective study
Authors: Dai Daopeng , Huang Chunkai , Ni Jinwei , Zhu Zhenbin , Han Hui , Zhu Jinzhou , Zhang Ruiyan 
Published: July 2019

AbstractRecent evidence has indicated that the lymphatic vessel endothelial hyaluronan receptor (LYVE-1) is implicated in chronic inflammation and the lymphatic immune response. The soluble form of LYVE-1 (sLYVE-1) is produced by ectodomain shedding of LYVE-1 under pathological conditions including cancer and chronic inflammation. In this study, 1014 consecutive patients who underwent coronary angiography from May 2015 to September 2015 were included to investigate whether serum sLYVE-1 is associated with coronary artery disease (CAD) and its concomitant diseases includes chronic kidney disease (CKD). Results showed that there was no significant difference in sLYVE-1 levels between patients with CAD and without. However, a significantly higher level of sLYVE-1 was seen in patients with renal dysfunction compared to those with a normal eGFR. Results were validated in a separate cohort of 259 patients who were divided into four groups based on their kidney function assessed by estimated glomerular filtration rate (eGFR).Simple bivariate correlation analysis revealed that Lg[sLYVE-1] was negatively correlated with eGFR (r = −0.358,p < 0.001) and cystatin C (r = 0.303,p < 0.001). Multivariable logistic regression analysis revealed that the increase in Lg[sLYVE-1] was an independent determinant of renal dysfunction (odds ratio = 1.633,p = 0.007). Therefore, renal function should be considered when serum sLYVE-1 is used as a biomarker for the detection of pathological conditions such as chronic inflammation and cancer. Further study is required to elucidate the exact role of sLYVE-1 in renal function.
Acute Traumatic Cervical Central Cord Syndrome—Is Early Intervention Justified?
Authors: Saha Rahul , Chatterjee Sandip 
Published: July 2019

AbstractThe clinical features suggestive of traumatic central cord syndrome (TCCS) were presented by Thorburn in his publication in 1887. Later in 1954, Schneider first mentioned the involvement of central cervical spinal cord after an acute cervical spine injury and described it as TCCS. This is generally caused due to an extreme hyperextension injury without vertebral damage and secondary to anteroposterior pinching or squeezing of the spinal cord. There exists a lot of controversy whether early surgical intervention is justified in these patients. It is to assess our own results that we decided to review 40 such cases treated by the senior author in the past 8 years. Twenty-four of these were managed with early surgical intervention (which we defined as within 48 hours), and 16 were treated conservatively. In all cases, the existence of fracture-dislocation, disc prolapse, as well as preoperative and postoperative Japanese Orthopaedic Association (JOA) scores and exact motor and sensory deficit were recorded. The numbers are too few, but there was definite evidence that patients with disc prolapse and fracture dislocation did better with surgery than with conservative treatment. Those with grade 0 power in the upper limbs however did significantly better with surgical treatment. Those with advanced pre-existing cervical spondylotic changes did better than those without these premorbid changes. However, the numbers are too small for meaningful statistical analysis. This is a retrospective study conducted as a pilot study to plan for a future randomized study, which is very necessary in our clinical practice. Currently, we still quote the pros and cons of surgical intervention to the relatives and go by their choice.
Successful Management of Adolescent Bupropion Overdose with Intravenous Lipid Emulsion Therapy
Authors: Bornstein Kasha , Montrief Tim , Anwar Parris Mehruba 
Published: July 2019

AbstractBupropion overdose in the pediatric setting poses significant potential for toxicity. We present the case of a 15-year-old female patient presenting with intentional bupropion overdose resulting in generalized tonic–clonic seizures, severe acidosis, vomiting, and tachycardia after ingestion of between 1,650 to 9,000 mg (24–133 mg/kg) of bupropion. The patient was admitted to pediatric intensive care unit (PICU) where toxicity was resolved promptly following administration of intravenous lipid emulsion (ILE) infusion. ILE is a first-line treatment for other forms of toxicity including unintended local anesthetic administration. ILE use is not a first-line treatment in this setting, but this case presents a positive subsequent patient outcome.
A Review of Psychosocial Factors of Marfan Syndrome: Adolescents, Adults, Families, and Providers
Authors: Nielsen Cory , Ratiu Ileana , Esfandiarei Mitra , Chen Angela , Selamet Tierney Elif Seda 
Published: July 2019

AbstractThe purpose of this article was to review the current literature on psychosocial implications of Marfan syndrome (MFS) and its impact on adolescents, adults, their families and to provide important considerations for providers. Since the previous reviews in 2015, numerous studies have been published that are included in the current review. This literature review was conducted using PubMed, Medline, PsychINFO, ERIC, Web of Science, and Academic Search Premier databases and only articles that studied psychosocial factors that influence MFS patients as adolescents, adults, family members, or their interactions with providers were included in this review. Of the 522 articles reviewed, 41 were selected based on the inclusion and exclusion criteria. All articles were peer-reviewed. MFS has various implications that can impact one's life; studies have shown that MFS causes a negative impact on an individual's formative years, quality of life, reproductive decision-making, work participation, and satisfaction with life. Clinicians and multidisciplinary teams should be aware of these factors to provide support focusing on coping strategies for the patient and their family.
Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock
Authors: Orvedahl Anthony , McAllaster Michael R. , Sansone Amy , Dunlap Bria F. , Desai Chandni , Wang Ya-Ting , Balce Dale R. , Luke Cliff J. , Lee Sanghyun , Orchard Robert C. , Artyomov Maxim N. , Handley Scott A. , Doench John G. , Silverman Gary A. , Virgin Herbert W. 
Published: July 2019

SignificanceSepsis is a multifactorial syndrome with increasing incidence and significant mortality. While previous work implicated tumor necrosis factor (TNF)-induced cell death in sepsis, a role for interferon-gamma (IFNγ), which synergizes with TNF to activate macrophages, is incompletely understood. We demonstrate using genome-wide CRISPR/Cas9 screening that genes regulating the cytosolic degradative pathway of autophagy protect against IFNγ-induced cell death. This cell death requires TNF and its receptor and depends on the downstream cell death mediators caspase-8 and RIPK1. Moreover, mice with myeloid cell autophagy gene deficiency are hypersusceptible to fatal TNF-induced shock, which also depends on IFNγ signaling and RIPK1. These findings identify autophagy genes as important regulators of IFNγ- and TNF-mediated cell death with implications for fatal systemic inflammatory responses.
Criteria for single photon sources with variable nonclassicality threshold
Authors: Lachman Lukáš , Filip Radim 
Published: July 2019

Abstract
Single photon sources are necessary for optical quantum technology. The nonclassicality of emitted single photons manifests itself in diverse experiments and applications. The applications already require different nonclassical aspects of single photons, however, a suitable hierarchy of criteria is missing. We propose variable experimental tests, based on adjustable linear optical networks and single photon detectors, giving a hierarchy of such nonclassicality criteria. The hierarchy goes beyond Hanbury–Brown–Twiss test of photon antibunching and allows us to compare faithfully quality and performance of single photon sources via their nonclassical properties.
Database-driven high-throughput study of coating materials for hybrid perovskites
Authors: Seidu Azimatu , Himanen Lauri , Li Jingrui , Rinke Patrick 
Published: July 2019

Abstract
We developed a high-throughput screening scheme to acquire candidate coating materials for hybrid perovskites. From more than 1.8 million entries of an inorganic compound database, we collected 93 binary and ternary materials with promising properties for protectively coating halide-perovskite photoabsorbers in perovskite solar cells. These candidates fulfill a series of criteria, including wide band gaps, abundant and non-toxic elements, water-insoluble, and small lattice mismatch with surface models of halide perovskites.
Entangling two magnon modes via magnetostrictive interaction
Authors: Li Jie , Zhu Shi-Yao 
Published: July 2019

Abstract
We present a scheme to entangle two magnon modes in a cavity magnomechanical system. The two magnon modes are embodied by collective motions of a large number of spins in two macroscopic ferrimagnets, and couple to a single microwave cavity mode via magnetic dipole interaction. We show that by activating the nonlinear magnetostrictive interaction in one ferrimagnet, realized by driving the magnon mode with a strong red-detuned microwave field, the two magnon modes can be prepared in an entangled state. The entanglement is achieved by exploiting the nonlinear magnon-phonon coupling and the linear magnon-cavity coupling, and is in the steady state and robust against temperature. The entangled magnon modes in two massive ferrimagnets represent genuinely macroscopic quantum states, and may find applications in the study of macroscopic quantum mechanics and quantum information processing based on magnonics.
Ultrafast infrared spectroscopy with single molecular ions
Authors: Schindler Philipp 
Published: July 2019

Abstract
We propose a method to investigate the vibrational dynamics of single polyatomic molecular ions confined in a Paul trap. Quantum logic techniques are employed to detect the recoil of single photon absorption events on the molecule via a co-trapped atomic ion. In particular, the recoil is mapped onto the electronic state of the atom which can be read out with high fidelity. This recoil detection serves as the basis for a pump-probe scheme to investigate ultrafast molecular dynamics, such as intra-molecular vibrational redistribution. The total recoil from the interaction with a sequence of ultrafast laser pulses with the molecular vibration is measured. This work discusses the experimental requirements and expected performance for multiple molecular ions with masses ranging from 17 to 165 Dalton.
The chiral biquadratic pair interaction
Authors: Brinker Sascha , Dias Manuel dos Santos , Lounis Samir 
Published: July 2019

Abstract
Magnetic interactions underpin a plethora of magnetic states of matter, hence playing a central role both in fundamental physics and for future spintronic and quantum computation devices. The Dzyaloshinskii–Moriya interaction,

D

ij

·
(

S

i

×

S

j

)

, being chiral and driven by relativistic effects, leads to the stabilization of highly-noncollinear spin textures such as skyrmions, which thanks to their topological nature are promising building blocks for magnetic data storage and processing elements. Here, we reveal and study a new chiral pair interaction,

C

ij

·
(

S

i

×

S

j

)
(

S

i

·

S

j

)

, which is the biquadratic equivalent of the DMI. First, we derive this interaction and its guiding principles from a microscopic model, and we connect the atomistic form to the micromagnetic one. Second, we study its properties in the simplest prototypical systems, magnetic 3d transition metal dimers deposited on the Pt(111), Pt(100), Ir(111), and Re(0001) surfaces, resorting to systematic first-principles calculations. Lastly, we discuss its importance and implications not only for magnetic dimers but also for extended systems, namely one-dimensional spin spirals and complex two-dimensional magnetic structures, such as a nanoskyrmion lattice found in an Fe monolayer on Ir(111).
The co-pollutant cost of carbon emissions: an analysis of the US electric power generation sector
Authors: Dedoussi Irene C , Allroggen Florian , Flanagan Robert , Hansen Tyler , Taylor Brandon , Barrett Steven R H , Boyce James K 
Published: July 2019

Abstract
Fossil fuel combustion releases carbon dioxide into the atmosphere along with co-pollutants such as sulfur dioxide, nitrogen oxides, and others. These emissions result in environmental externalities primarily in terms of climate and air quality. Here we quantify the cost of co-pollutant emissions per ton of CO2 emissions from US electric power generation. We measure the co-pollutant cost of carbon (CPCC) as the total value of statistical life associated with US-based premature mortalities attributable to co-pollutant emissions, per mass of CO2. We find an average CPCC of ∼$45 per metric ton (mt) of CO2 for the year 2011 (in 2017 USD). This is ∼20% higher than the central Social Cost of Carbon (SCC) measure of climate damages that was used by the Obama administration in its regulatory impact analysis for the Clean Power Plan (CPP), and >8 times higher than the SCC used by the Trump administration in its analysis for the Plan’s repeal. At the state-level, the CPCC ranged from ∼$7/mt CO2 for Arizona to ∼$96/mt CO2 for New Jersey. We calculate the CPCC trends from 2002 to 2017 and find a 71% decrease at the national level, contributing to total savings of ∼$1 trillion in averted mortality from power plant emissions over this period. By decomposing the aggregate and fuel-specific co-pollutant intensities into simultaneous (CO2-driven) and autonomous components, we conclude that the CPCC trends originated mainly from targeted efforts to reduce co-pollutant emissions, e.g. through fuel switching (from coal to natural gas) and autonomous changes in co-pollutant emissions. The results suggest that the overall benefit to society from policies to curtail carbon emissions may be enhanced by focusing on pollution sources where the associated air-quality co-benefits are greatest. At the same time, continued efforts to reduce co-pollutant intensities, if technologically feasible, could help to mitigate the air-quality damages of the CPP’s repeal and replacement.
Potentiometric analysis of metastable carbonate water coolants of thermal power plants and heat supply systems
Authors: Chichirov A A , Filimionova A A , Gilfanov B A , Gafiatullina A A , Chichirova N D 
Published: July 2019

Abstract
The paper describes a new method for studying the structure of metastable carbonate solutions, based on obtaining pK- and pH-spectra of solutions from potentiometric titration data. The decoding method is used to obtain the equations for calculating the coordinates of the spectra. In the production of thermal and electrical energy in modern thermal power plants (TPP) operate with water systems that have a constantly producing phase instability. Such systems include (1) water systems in intermediate stages of water treatment, in particular lime-coagulated or clarified water after pre-treatment, (2) cooling water in the circulating cooling system (COO) of the station, (3) water heat transfer medium in conjugated heat networks, (4) boiler water. All these systems are characterized by the presence of a stabilized (metastable) solid phase, mainly calcium carbonate, capable of forming a crystalline phase of calcite under certain conditions. The crystallization process is undesirable, since it can lead to dense deposits on the heat exchange surfaces. Approximately the instability of such systems is characterized by the value of ΔQw - by changing the total alkalinity of water in time (hours, days). The method of quantitative determination of stabilized calcium carbonate in water systems of TPPs is currently lacking. Development of a technique for potentiometric analysis of carbonate-alkaline solutions.
Atomic force microscopy and IR spectrometry application in detecting the type and nature of contaminants on reverse osmosis membrane elements
Authors: Chichirova N D , Chichirov A A , Saitov S R 
Published: July 2019

Abstract
The main, the most acute problem of barometric technology today is reagent provision. For its stable and trouble-free operation, a complex of expensive and unique chemical reagents (biocides, antiscales, washing compositions) is required. Each manufacturer develops his own chemical composition for a certain membrane type. This leads to a significant cost rise of reagents, as well as creates a dependence of the consumer technology from a particular supplier. However, these reagents do not always meet the quality requirements - despite the guarantees provided by manufacturers, the equipment fails before the due service life as a result of deposits in the pores and on the membrane surfaces. To develop a more effective washing composition, it is required to determine the type and consist of these deposits. The report illustrates the methods for determining the consist and type of deposits on reverse osmosis membranes. The solution of the problem of reagent provision for the example of the wastewater treatment plant at the Ashalchinsky field of the extra-viscous oil of PJSC “Tatneft” is presented.
Reagent approach for silicate deposits prevention in waste heat boilers
Authors: Khasanova D.I. , Panteleev A.A. 
Published: July 2019

Abstract
New reagent composition with optimal phosphate:thermal polymer ratio has been developed and studied for steam-and-condensate channel protection and its corrosion prevention as well as for on-line washing to remove old silicate deposits formations. Optimal dosage and water-chemistry conditions for a medium pressure steam boiler with specified quality of feed water have been selected. The causes of silicate deposits in medium pressure waste-heat boiler have been analyzed. The reagent efficiency has been evaluated while industrial applications.
Adsorption of industrial wastewater from oil products with application of mathematical modeling
Authors: Nikolaeva L.A. , Iskhakova R. Ya. 
Published: July 2019

Abstract
The granulated hydrophobic sorption material created on the basis of the chemical water treatment sludge of thermal power plants “SM-5” is studied. The information basis obtained in the experiments on the kinetics of adsorption makes it possible to model the dynamics of adsorption in a fixed bed of “SM-5” granules.
Modern water treatment system for high-quality water used in the energy industry
Authors: Rakhmetova E , Kozodaev A , Zavyalova A , Kondrateva O , Zvonkova N 
Published: July 2019

Abstract
This article provides the detailed optimization processes and enhancement, in the field of water treatment systems, for the energy sector needs. The developing of the unique water purification system design based on modern techniques for equipment is presented according to ASTM standards. As well as the project proposes a new methodology for complex analysis of quality data after each purification section in order to manage all possible need in the water for the power plant. The analysis allows producing the more accurate selection of the filter systems, thereby prevent failures of such sophisticated and expensive equipment as reverse osmosis and continuous electrodeionization.
Definition of an optimum method of water preparation for needs of the enterprises
Authors: Rotach R.R. , Akhmetov E.A. , Gaponenko S.O. 
Published: July 2019

Summary
Results of technical and economic calculations for various methods of water desalting are presented in article. The prime cost of the desalted water received by each of the considered methods is calculated (in costs of thermal and electric energy). On the basis of the obtained data conclusions are drawn on applicability of each of the considered water desalting methods.
Energy, mass-exchange and hydrodynamic efficiency of degassers at low-temperature deaeration of water for thermal power plants
Authors: Sharapov V.I. , Mingaraeva E.V. 
Published: July 2019

Abstract
A new technology for low-temperature degassing of the make-up water was developed using natural gas as a desorbing agent. The calculation of the energy efficiency of the developed technology for a typical power unit of the heat power plants (HPPs) is performed. Theoretically necessary and actual specific costs of natural gas are estimated to ensure the normative quality of the deaeration. The calculation of the hydrodynamic characteristics of the atmospheric deaerator at work on natural gas is presented.
Purification of natural water and wastewater from petroleum and petroleum products by sorption materials on a basis of industrial waste
Authors: Tatarintseva E A , Dolbnya I V , Bukharova E A , Olshanskaya L N , Politaeva N A 
Published: July 2019

Abstract
Results of experimental research of sorption purification of wastewater and surface water from petroleum and petroleum products by sorption materials on a basis of industrial waste have been given. Polyethylene terephthalate, ferritized galvanic sludge (FGS), oxidized and thermally expandable graphite have been chosen as the components of the sorption materials (SM). The sorption material on the basis of FGS has magnetic properties and it allows to extract the sorbent from water with the help of a magnetic separation. Physical and chemical properties of SM (buoyancy, water adsorption, petroleum capacity), kinetic regularities of the sorption of petroleum products by the sorption materials have been studied. Specific surface area, porosity, and particles dispersion have been determined. A possibility of using sorbents to collect petroleum products from the water surface has been shown.