bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vanillin: The Case for Greener Production Driven by Sustainability Megatrend
Authors: Ciriminna Rosaria , Fidalgo Alexandra , Meneguzzo Francesco , Parrino Francesco , Ilharco Laura M. , Pagliaro Mario 
Published: May 2019

AbstractApproaching the end of the second decade of the 21st century, almost the whole demand of vanillin is met by the synthetic product obtained either via a petrochemical process starting from phenol and glyoxylic acid or from energy intensive alkaline oxidative depolymerization of lignin. Only a minor fraction is comprised of natural vanillin obtained from ferulic acid fermentation, and even less of highly valued Vanilla planifolia extracts. Are there alternative green production methods? And, if yes, are they suitable to find practical application?
Integrated psychology support and comprehensive cognitive evaluation improves access to special education services for children with sickle cell disease
Authors: Ghafuri Djamila Labib , Sanger Maureen , Rodeghier Mark , DeBaun Michael Rutledge 
Published: May 2019

AbstractBackgroundChildren with sickle cell disease (SCD) are at risk for cognitive deficits. Limited data describe whether comprehensive cognitive evaluation improves education resources and whether caregivers perceive the assessment as beneficial. We tested our two hypotheses: (a) an integrated comprehensive cognitive evaluation program in children with SCD results in increased special education services allocation; and (b) caregivers will value comprehensive cognitive evaluation services provided.ProcedureIn a tertiary care medical facility, as part of quality improvement project, in a before‐and‐after evaluation between March 2011 and July 2014, we examined the impact of targeted comprehensive cognitive evaluation on change in special education services. We also evaluated the caregiver's perception regarding the utility of the provided services.ResultsA total of 21% (42 of 196) students (median age 11 years, range 3‐18) with SCD were referred for cognitive assessment due to overt stroke (n = 11), silent stroke (n = 14), or concerns about cognitive or academic functioning without evidence of strokes (n = 17). At baseline, 45.2% received special education services and after the comprehensive cognitive evaluation 86.7% received special education services (P < 0.001). Among 33 caregivers who completed the survey, 97% reported that the assessment was helpful and 60% indicated that assessment led to beneficial changes for their children at school.ConclusionEducation advocacy coupled with comprehensive cognitive assessment in students with SCD improved access to special education services, and caregivers uniformly endorse this service as having added value.
Impact of a transition program with navigator on loss to follow‐up, medication adherence, and appointment attendance in hemoglobinopathies
Authors: Allemang Brooke , Allan Kate , Johnson Colleen , Cheong Melina , Cheung Patrina , Odame Isaac , Ward Richard , Williams Suzan , Mukerji Geetha , Kuo Kevin H.M. 
Published: May 2019

AbstractBackgroundTransition from pediatric to adult care is a period of high risk for loss to follow‐up, morbidity, and mortality in adolescents and young adults (AYA) with hemoglobinopathies. The purpose of this study was to determine whether a transition program with transition navigator (TN) reduced loss to follow‐up and hospitalizations and improved medication adherence and appointment attendance compared with an unstructured transfer.ProcedureA retrospective observational study compared all AYA with hemoglobinopathies who turned 18 one year prior to (n = 51) and one year after (n = 61) the initiation of the transition program. Data from one year prior to last pediatric appointment and one year following first adult appointment were collected from each patient.ResultsThe transition program with TN reduced loss to follow‐up from 29% to 7% (P = 0.034). A greater proportion of patients in the transition cohort maintained or improved adherence to hydroxyurea or iron chelation to ≥4 days/week; exposure to the program was independently associated with such improvement (P = 0.047). A trend toward improvement or maintenance of ≥90% attendance to appointments was observed (P = 0.096). Frequency of hospitalization was not significantly different between the two cohorts (P = 0.985).ConclusionsA transition program with TN significantly reduced loss to follow‐up, and significantly improved and maintained fair to good medication adherence. Further analysis of economic benefit and patient satisfaction will be conducted.
Signaling pathways and inhibitors of cells from patients with kaposiform lymphangiomatosis
Authors: Boscolo Elisa , Pastura Patricia , Glaser Kathryn , Goines Jillian , Hammill Adrienne M. , Adams Denise M. , Dickie Peter , Hsi Dickie Belinda , Le Cras Timothy D. 
Published: May 2019

AbstractBackgroundKaposiform lymphangiomatosis (KLA) is a rare lymphatic anomaly with significant morbidity and mortality. KLA is characterized by diffuse multifocal lesions comprised of focal areas of “kaposiform” spindled cells accompanying malformed lymphatic channels. The goal of this study was to identify activated signaling pathways in cells isolated from three KLA patients for the purpose of testing new therapies.ProcedureCells were obtained from the lungs of one patient isolated at autopsy and the spleen of two patients removed in surgery due to disease complications. A protein kinase array was performed on the KLA cell lysates and normal lymphatic endothelial cells.ResultsHigher activation of key signaling pathways in the KLA cells, including PRAS40, AKT1/2/3, and ERK‐1/2, was identified by protein kinase array and confirmed by Western blot analysis. This indicated a role for highly activated PI3K–AKT and MAPK–ERK‐1/2 signaling pathways in KLA cells. Cell proliferation studies assessed PI3K inhibitors (LY294002; BYL719), AKT inhibitor ARQ092, mTOR inhibitor rapamycin, and MAPK inhibitor U0126. These studies demonstrated that PI3K–AKT–mTOR and MAPK signaling are important mediators of KLA cell proliferation. BYL719 and rapamycin were more effective at inhibiting KLA cell proliferation than U0126.ConclusionsOur studies using cells from KLA patient lesions demonstrate that these cells are highly proliferative and the PI3K–AKT–mTOR and MAPK pathways are promising therapeutic targets. Development and clinical trials of PI3K, AKT, and MAPK inhibitors for cancer treatment and the data in this study lend support for early clinical trials assessing the efficacy of these inhibitors in KLA patients.
Outcomes of hypoplastic left heart syndrome and fetal aortic valvuloplasty in a country with suboptimal postnatal management
Authors: Cruz‐Lemini Mónica , Alvarado‐Guaman Monica , Nieto‐Castro Belen , Luna‐Garcia Jonathan , Martínez‐Rodríguez Miguel , Juarez‐Martínez Israel , Palacios‐Macedo Alexis , Cruz‐Martínez Rogelio 
Published: May 2019

What is already known about this topic?

Fetal aortic valvuloplasty may prevent progression to hypoplastic left heart syndrome (HLHS) in utero and, thus, decrease postnatal morbidity
Despite the high survival rate of HLHS in developed countries, many studies suggest that the risks of this fetal intervention may outweigh the benefits.
What does this study add?

Fetal aortic valvuloplasty is associated with ≈50% long‐term survival, while HLHS currently carries more than 95% risk of perinatal death in countries with suboptimal postnatal management, with little or no experience regarding surgical palliation, and with the vast majority of cases receiving comfort measures.
Variation of clinical manifestations according to culprit drugs in DRESS syndrome
Authors: Sim Da Woon , Yu Ji Eun , Jeong Jiung , Jung Jae‐Woo , Kang Hye‐Ryun , Kang Dong Yoon , Ye Young Min , Jee Young‐Koo , Kim Sujeong , Park Jung‐Won , Kang Min Gyu , Kim Sae Hoon , Park Hye‐Kyung , Yang Min‐Suk , Hur Gyu‐Young , Lee Jun Kyu , Choi Jeong‐Hee , Kwon Yong Eun , Koh Young‐Il ,   Korean Severe Cutaneous Adverse Reactions Consortium
Published: May 2019

AbstractPurposeDrug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but serious condition that systematically damages various internal organs through T‐cell–mediated immunological drug reactions. We aimed to investigate whether clinical manifestations of DRESS syndrome differ according to culprit drugs.MethodsWe retrospectively analyzed data from 123 patients with probable/definite DRESS syndrome based on the RegiSCAR criteria (January 2011 to July 2016). The data were obtained from the Korean Severe Cutaneous Adverse Reaction Registry. Causality was assessed using the World Health Organization‐Uppsala Monitoring Centre criteria. The culprit drugs were categorized as allopurinol, carbamazepine, anti‐tuberculosis drug, vancomycin, cephalosporins, dapsone, and nonsteroidal anti‐inflammatory drugs.ResultsDifferences were observed among culprit drugs regarding the frequencies of hepatitis (P < 0.01), renal dysfunction (P < 0.0001), lymphadenopathy (P < 0.01), and atypical lymphocyte (P < 0.01). Latency period differed among culprit drugs (P < 0.0001), being shorter in vancomycin and cephalosporin. In terms of clinical severity, admission duration (P < 0.01) and treatment duration (P < 0.05) differed among culprit drugs, being longer in vancomycin and anti‐tuberculosis drugs, respectively.ConclusionsBased on the findings, clinical manifestations, including latency period and clinical severity, may differ according to culprit drugs in DRESS syndrome.
Genug Platz an der Sonne
Authors: Stierstadt Klaus 
Published: May 2019

ZusammenfassungEine Frage, die beim Ausbau erneuerbarer Energieerzeugung immer wieder aufkommt, ist die nach dem Flächenbedarf. Eine Abschätzung auf Basis heutiger Daten zeigt: Grundsätzlich ist mehr als genug Platz in Deutschland für eine hundertprozentige Umstellung der Stromproduktion auf Sonne, Wasser und Wind. Global gesehen gilt dies sogar für eine auf zehn Milliarden angewachsene Menschheit. Dabei muss allerdings die Solarenergie einen wesentlichen Anteil übernehmen.
Synthesis of hydroxyl‐bearing polyurethanes from naturally occurring myo‐inositol
Authors: Sudo Atsushi , Kaiba Kohei 
Published: May 2019

ABSTRACTA route from naturally occurring myo‐inositol to hydroxyl‐bearing polyurethanes has been developed. The diol prepared from the bis‐acetalization of myo‐inositol with 1,1‐dimethoxycyclohexane was reacted with a rigid diisocyanate, 1,3‐bis(isocyanatomethyl)cyclohexane to afford the corresponding polyurethane, of which glass transition temperature (Tg) was quite high as 192 °C. The polyurethane contains side chains inherited from the acetal moieties of the diol monomer and was treated with trifluoroacetic acid to hydrolyze the acetal moieties and afford the target polyurethane functionalized with hydroxyl groups. The presence of many hydroxyl groups in the side chains, which can form hydrogen bonds with each other, resulted in a high Tg, 186 °C. In addition, the hydroxyl groups were reacted with isocyanates to achieve further side‐chain modifications. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 1358–1364
The role of oxygen on the growth of palladium clusters synthesized by gas aggregation source
Authors: Chamorro‐Coral William , Caillard Amaël , Brault Pascal , Andreazza Pascal , Coutanceau Christophe , Baranton Stève 
Published: May 2019

AbstractPalladium clusters are grown using a gas aggregation source coupled to magnetron sputtering with oxygen as reactive gas. Clusters with a mean size between 2.6 and 3.3 nm are obtained. Oxygen enhances the deposition rate by a factor 3 (from 4 to 11 mg/h cm
−2) at the expense of the formation of larger clusters and the modification of the cluster composition. An increase of the oxygen flow rate induces a transition from Pd to PdO, this transition is followed by the formation of 2D structural defects in the crystals as displayed by grazing incidence X‐ray diffraction and high resolution transmission electron microscopy micrographs. Oxygen interacts with both the target and the sputtered atoms, highlighting that the target oxidation could be considered as the key step that drives the cluster growth processes.
Visualizing when prior information can reduce the necessary size of a reference sample when estimating in‐control parameters for Shewhart and CUSUM charts for a normal process
Authors: Jeske Daniel R. , Wang Yijia 
Published: May 2019

AbstractWe consider the construction of Shewhart and cumulative sum (CUSUM) charts for a normal process when the in‐control mean and standard deviation must be estimated from a reference sample. Unless the reference sample size is extremely large, substituting the unknown mean and standard deviation with the sample estimates from the reference sample will introduce alarming variability in the conditional (on the reference sample estimates) in‐control average run length. In most applications, some prior information for the mean and standard deviation is available. We investigate how effective Bayes estimators can be in terms of reducing the necessary size of the reference sample. We consider both uniform and conjugate priors, and we show how to construct a graphic that depicts the relationship between the precision in the prior and the relative error in the conditional in‐control average run length.
Robotic sentinel node mapping in clinical stage 1 endometrial cancer using methylene blue dyes using the robotic platform
Authors: Le Tien , McDonald Shannen , Samant Rajiv , Fung Kee Fung Michael 
Published: May 2019

AbstractPurposeEndometrial cancer is a surgically staged cancer. We examined our preliminary experience with sentinel lymph node (SLN) mapping in early stage endometrial cancer using methylene blue dyes.MethodRetrospective review of all clinically stage 1 endometrial cancer staged surgically using the robotic platform. Logistic regression models were built to predict nodal metastasis taking into account age, grade, histology, depth of myometrial invasion, cervical involvement, and use of SLN mapping.ResultsFour hundred sixty‐nine patients were reviewed. Sixty patients had SLN mapping (13%). Four hundred nine patients underwent standard lymphadenectomy with five documented nodal metastasis (1.2%). Five nodal metastasis (8.3%) were seen in the SLN patients. In the logistic model, the application of SLN mapping was significantly associated with diagnosed nodal metastasis (OR 7.74; 95% CI, 2.04‐29.3; P = .003) together with nonendometroid histology (OR 5.05; 95% CI, 1.27‐20.12; P = .022).ConclusionSLN mapping protocol using methylene blue significantly identifies more nodal metastasis than standard lymphadenectomy.
Mesenchymal Stem Cell-Derived Extracellular Vesicles as Therapeutics and as a Drug Delivery Platform
Authors: Baek Gyuhyeon , Choi Hojun , Kim Youngeun , Lee Hai-Chon , Choi Chulhee 
Published: May 2019

SummaryMesenchymal stem cells (MSCs) are one of the most easily accessible stem cells that can be obtained from various human tissues. They have raised considerable interests for their potential applications in tissue repair, anti-cancer therapy, and inflammation suppression. Stem cell-based therapy was first used to treat muscular dystrophies and has been studied intensively for its efficacy in various disease models, including myocardial infarction, kidney injuries, liver injuries, and cancers. In this review, we summarized the potential mechanisms underlying MSC-derived EVs therapy as a drug delivery platform. Additionally, based on currently published data, we predicted a potential therapeutic role of cargo proteins shuttled by EVs from MSCs. These data may support the therapeutic strategy of using the MSC-derived EVs to accelerate this strategy from bench to bedside. Stem Cells Translational Medicine 2019;8:880–886
A Theoretical Model to Study the Interaction of Erythro‐Noscapines with nsP3 protease of Chikungunya Virus
Authors: Kumar Durgesh , Singh Prashant , Jayaraj Abhilash , Kumar Vinod , Kumari Kamlesh , Patel Rajan 
Published: May 2019

AbstractFor the better management and control of the viral replication, it is essential to discover a potential molecule to combat Chikungunya virus (CHIKV). The work aims to find a potential antiviral molecule via its interactions with the non‐structural protease (nsP3) of CHIKV. It plays a crucial role in intracellular replication. The best molecular interaction is based on the minimum total binding energy of hydrogen bonding, electrostatic interaction and van der Waals forces. It was found that Erythro‐noscapines showed good binding affinity with nsP3 protease of CHIKV (PDB ID: 3GPO) and minimum total binding energy (‐149.964 kcal/mol) to form a more stable complex i. e. 109‐nsP3 protease of CHIKV. Erythro‐noscapines (109, one of the derivatives of erythro‐noscapine) showed better interaction than the reported molecules by different reseach groups via docking. The parameters for bioactivity score and Lipinski “Rule of Five” were calculated to estimate the pharmacokinetic properties of antiviral Erythro‐noscapines and compared to others. 109 can be considered as a good candidate for antiviral replication against nsP3 protease of CHIKV. Molecular dynamics simulations on nsP3 protease of CHIKV with or without 109 was performed and studied. Further, binding free energies of potential noscapine‐nsP3 protease of CHIKV based on Molecular Mechanics‐Generalized Born Suface Area (MM‐GBSA) was calculated. Further, toxicity of top 10 noscapines and reported molecules by different research groups was determined and then, density functional theory was applied to understand the singlet and triplet states of the 109.
A Dual Level Direct Dynamics Study for the Reaction of CF2=CHCF3 (HFC‐1225 zc) and CF2=CHCF2CF3 (HFC‐1327 cz) towards OH Radicals
Authors: Gupta Parth , Rajakumar Balla 
Published: May 2019

AbstractLong carbon‐chain framework Hydrofluoroolefin (HFOs) systems are considered to be successful alternatives to the routine Hydrofluorocarbons (HFCs). The influence of these HFOs can be understood based on their chemical interaction(s) with the atmospheric oxidants. Therefore, to better assess the impact of HFC‐1225zc and HFC‐1327cz on the Earth's atmosphere, kinetics was investigated with atmosphere's most powerful oxidant, OH radical, in the temperature range of 200–400 K using the CCSD(T)/cc‐pVTZ//M062x/6‐31+G(d,p) level of theory. Temperature dependent hindered‐rotor corrected rate coefficients for the corresponding OH‐addition and H‐abstraction channels were determined using the dual‐level direct dynamics with the Interpolated Single Point Energy method (VTST/ISPE) in conjunction with the Small‐Curvature Tunneling (SCT) corrections. Among the two channels studied, addition channels played an essential role in determining the global reactivity of these HFOs. The global rate coefficients (in 10−13 cm3 molecule−1 sec−1) obtained at 298 K are; k(CF2=CHCF3+OH)=9.41 and k(CF2=CHCF2CF3+OH)=9.11 respectively. COF2, CF3CHO, CF3COCF2OH, CF3CF2CH(F)O, CF3COOH and CF3CF2COOH are the major products formed via the possible O2‐NOx initiated product degradation mechanism for these HFOs. The atmospheric lifetimes for these molecules were found to be 31 and 14 days respectively. Radiative Efficiencies (REs), Global‐Warming Potentials (GWPs), and Photochemical Ozone Creation Potentials (POCPs) are also reported as part of this work.
Cobalt (II) Complexes Derived from Azo‐Azomethine Ligands: Synthesis, Characterization, Solvatochromic, Fluorescence, Thermal, Electrochemical and Antimicrobial Properties
Authors: Arabahmadi Raziyeh 
Published: May 2019

AbstractThree new cobalt (II) complexes were prepared by the condensation between the ligands, 1‐{3‐[(1‐ethoxy‐2‐hydroxyethyl‐imino)methyl]‐4‐hydroxyphenylazo}‐4‐nitro benzene (L1), 1‐{3‐[(1‐ethoxy‐2‐hydroxethyl‐imino)methyl]‐4‐hydroxyphenylazo}‐2‐chloro‐ 4‐nitrobenzene (L2) and 1‐{3‐[(1‐ethoxy‐2‐hydroxyethyl‐imino)methyl]‐4‐hydroxyphenylazo}‐4‐chloro‐3‐nitrobenzene (L3), with cobalt(II) acetate (molar ratio 1:1) in methanol as the solvent. These prepared cobalt (II) complexes were characterized by infrared, UV/Vis and fluorescence spectroscopy, elemental analysis and magnetic susceptibility measurements. The redox behavior of Schiff base ligands and cobalt (II) complexes determined using cyclic voltammetry technique. The solvatochromic behavior of the Schiff base ligands L1‐L3 were recorded in three organic solvents with different polarity. On the basis of the UV/Vis and infrared spectra, the azo‐azomethin ligands coordinated to the Co (II) ion through phenolic oxygen, alcoholic oxygen, etheric oxygen and imino nitrogen. The prepared ligands and their complexes be served as photoactive materials due to their intraligand (π→π*) fluorescence. The effective magnetic moments of complexes CoL1, CoL2 and CoL3 are 3.95, 3.9 and 3.98 B.M., respectively that indicate these complexes have tetrahedral configuration. Thermal properties and decomposition behaviors of cobalt (II) complexes are reported by DTA/TG curves. Antibacterial activities of both ligands and complexes were studied.
Efficient Synthesis and Biological Evaluation of 2,4‐Diaminothieno[2,3‐d]pyrimidine Derivative
Authors: Hou Na , Man Jiang‐Hong , Wang Xian‐Yu , He Sheng‐Jie , Li Qing , Hu Yang‐Gen 
Published: May 2019

AbstractCancer is a main reason for human morbidity and mortality globally. Screening and identifying new anticancer chemical substances is considered as a valid treatment for carcinoma. In our study on synthesis and search towards the development of potential anticancer agents, a series of thieno[2,3‐d]pyrimidine derivatives were prepared from the functionalized iminophosphorane via aza‐Wittig reaction. Their structures were confirmed by 1H NMR, 13C NMR, MS and elemental analysis. The in vitro antitumor activities of compounds were analyzed with CCK8 standard method. It revealed these thieno[2,3‐d]pyrimidine derivatives were exhibited cytotoxicity against HepG2, HEp‐2, and MCF‐7 cell lines. The most potent compounds, 5 h and 5 j, were efficacious against HEp‐2 cells with IC50 1.8μmol/L and 0.8μmol/L, respectively. Meanwhile, 5 a, 5 d and 5 h showed broad spectrum of cytotoxicity for HepG2, Hep2 and MCF‐7 three different cell lines with IC50 range of 1.8‐87.5μmol/L. Furthermore, we demonstrated that cytotoxicity of 5 j was due to the activation of caspase‐9 involved apoptotic pathway, which is death receptor independent.
Detailed Reaction Mechanisms of 4‐Pyridylboronic Acid and (N‐Methyl)‐4‐Pyridinium Boronic Acid with D‐Sorbitol in Aqueous Solution
Authors: Kusuyama Daisuke , Samukawa Yuta , Sugaya Tomoaki , Iwatsuki Satoshi , Inamo Masahiko , Takagi Hideo D. , Ishihara Koji 
Published: May 2019

AbstractKinetic measurements of the reactions of (N‐methyl)‐4‐pyridinium boronic acid [(N−Me)‐4‐Py+B(OH)2] and 4‐pyridinium boronic acid [4‐HPy+B(OH)2] with D‐sorbitol in aqueous solution were performed, and the reaction mechanisms were clarified in detail. Both reactions proceeded in one step; i. e., the intermolecular rate‐determining step forming the 2,3‐bicoordinate product was followed by the fast intramolecular step from the bicoordinate product to the 2,3,5‐tricoordinate product. N‐Methylation of 4‐HPy+B(OH)2 was found to dramatically reduce the reactivity of the N‐methylated‐4‐pyridinium boronate ion [(N−Me)‐4‐Py+B(OH)3−], although it had little effect on the reactivity of (N−Me)‐4‐Py+B(OH)2. The reaction rates were enhanced by ion‐pair formation between the boronate ion and the protonated buffer cation.