bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of Betulungan on Multiethnic Women in Preserving The Haul Tradition in Samarinda East Kalimantan
Authors: Sunardi  , Rusmawaty Desy , Sultan Muhammad 
Published: November 2024

This ethnographic study investigates the Haul tradition's execution in Samarinda, East Kalimantan, emphasising the procedures and challenges of preserving this significant religious and cultural event. The Haul custom- an Islamic observance that pays tribute to esteemed progenitors or saints, is of great spiritual significance; however, it is currently facing contemporary challenges, such as ethnic diversity and generational shifts. Betulungan, a native term that signifies cooperation and communal assistance, is the foundation of the Haul's prosperity in Samarinda. Betulungan's role in fostering collaboration among women from various ethnic backgrounds—Javanese, Banjar, Kutai, and Dayak—who are involved in the administration and maintenance of the Haul is further clarified in this study. The research employed a case study methodology, utilising data collected from five key informants chosen for their substantial contributions to the organization of the Haul within their communities. The neighborhood leader, a critical participant in organising community events, is identified as a key informant because he fosters collaboration and ensures inclusion in this multiethnic environment. The research, conducted through participant observation and exhaustive interviews, illustrates how Betulungan is a conduit for bridging ethnic divides and promoting interethnic collaboration in preparing food, rituals, and logistics for the Haul. The data indicate that Betulungan fosters a collaborative environment where women, regardless of ethnicity, unify to achieve a common spiritual goal, thereby preserving the Haul heritage and enhancing social cohesiveness. In response to the socio-cultural dynamics of a modernizing, multiethnic Samarinda, the Haul heritage has continued to evolve, with the culture of mutual assistance being crucial to its preservation. The research improves understanding of the substantial role those local cooperative behaviors play in conserving cultural and religious traditions among various groups.
Optimalisasi BMN Idle sebagai Underlying Asset Sukuk Murabahah untuk Mendorong Pertumbuhan Ekonomi Indonesia
Authors: Ilmi Ghozi Akhyarul 
Published: November 2024

Pengelolaan aset pemerintah hakikatnya digunakan sebagai efektivitas dari pelayanan masyarakat dan maksimasi penggunaan sumber daya. Dalam hal ini, aspek ekonomi makro yang terdekat adalah investasi yang dapat ditanamkan pada BMN pemerintah sehingga BMN pemerintah dapat bernilai ekonomis dan produktif. Apabila BMN tidak digunakan secara efisien maka yang terjadi adalah existing asset yang idle dan underutilized sehingga pemerintah harus memberikan effort lebih pada biaya yang dikeluarkan dan akan terjadi financial burden. Financial burden ini akan menyebabkan pembengkakan anggaran dari APBN. Oleh karena itu, pemerintah harus mengubah pola pikir dari yang sebelumnya mengeluarkan expense kemudian mengubah pengeluaran ini menjadi investment. Pada analisis kali ini penulis menggunakan metode content analysis yang merupakan teknik penelitian kualitatif yang menekankan pembahasan pada suatu informasi dan menggunakan metode scoping review yang menggunakan metode menganalisis literatur dari berbagai sumber secara mendalam. Kesimpulan dalam analisis ini adalah sukuk murabahah merupakan solusi yang ditawarkan untuk menjawab isu-isu yang telah disebut.
Exposure to Road Traffic Noise and Incidence of Acute Myocardial Infarction and Congestive Heart Failure: A Population-Based Cohort Study in Toronto, Canada
Authors: Bai Li , Shin Saeha , Oiamo Tor , Burnett Richard T. , Weichenthal Scott , Jerrett Michael , Kwong Jeffrey C. , Copes Ray , Kopp Alexander , Chen Hong 
Published: November 2024

<p><strong>Background:</strong></p>
<p>Epidemiological evidence for the association between traffic-related noise and the incidence of major cardiovascular events such as acute myocardial infarction (AMI) and congestive heart failure (CHF) is inconclusive, especially in North America.</p>
<p><strong>Objectives:</strong></p>
<p>We evaluated the associations between long-term exposure to road traffic noise and the incidence of AMI and CHF.</p>
<p><strong>Methods:</strong></p>
<p>Our study population comprised ∼1 million people 30–100 years of age who lived in Toronto, Canada, from 2001 to 2015 and were free of AMI (referred to as the AMI cohort) or CHF (the CHF cohort) at baseline. Outcomes were ascertained from health administrative databases using validated algorithms. Annual average noise levels were estimated as the A-weighted equivalent sound pressure level over the 24-h period (LAeq24) and during nighttime (LAeqNight), respectively, using propagation modeling, and assigned to participants’ annual six-digit postal code addresses during follow-up. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for incident AMI and CHF in relation to LAeq24 and LAeqNight using random-effects Cox proportional hazards models adjusting for individual- and census tract–level covariates, including traffic-related air pollutants [e.g., ultrafine particles (UFPs) and nitrogen dioxide].</p>
<p><strong>Results:</strong></p>
<p>During follow-up, there were 37,441 AMI incident cases and 95,138 CHF incident cases. Each interquartile range change in LAeq24 was associated with an increased risk of incident AMI (HR=1.07; 95% CI: 1.06, 1.08) and CHF (HR=1.07; 95% CI: 1.06, 1.09). Similarly, LAeqNight was associated with incident AMI (HR=1.07; 95% CI: 1.05, 1.08) and CHF (HR=1.06; 95% CI: 1.05, 1.07). These results were robust to various sensitivity analyses and remained elevated after controlling for long-term exposure to UFPs and nitrogen dioxide. We found near-linear relationships between noise and the incidence of AMI and CHF with no evidence of threshold values.</p>
<p><strong>Conclusion:</strong></p>
<p>In this large cohort study in Toronto, Canada, chronic exposure to road traffic noise was associated with elevated risks for AMI and CHF incidence. </p>
Association Between Road Traffic Noise and Incidence of Diabetes Mellitus and Hypertension in Toronto, Canada: A Population‐Based Cohort Study
Authors: Shin Saeha , Bai Li , Oiamo Tor , Burnett Richard T. , Weichenthal Scott , Jerrett Michael , Kwong Jeffrey C. , S. Goldberg Mark , Copes Ray , Kopp Alexander , Chen Hong 
Published: November 2024

<p><strong>Background</strong></p>
<p>Exposure to road traffic noise has been linked to cardiometabolic complications, such as elevated blood pressure and glucose dysregulation. However, epidemiologic evidence linking road traffic noise to diabetes mellitus and hypertension remains scarce. We examined associations between road traffic noise and the incidence of diabetes mellitus and hypertension in Toronto, Canada.</p>
<p><strong>Methods and Results</strong></p>
<p>Using the Ontario Population Health and Environment Cohort, we conducted a retrospective, population‐based cohort study of long‐term residents of Toronto, aged 35 to 100 years, who were registered for provincial publicly funded health insurance, and were without a history of hypertension (n=701 174) or diabetes mellitus (n=914 607). Road traffic noise exposure levels were assessed by the equivalent continuous A‐weighted sound pressure level (dBA) for the 24‐hour day and the equivalent continuous A‐weighted sound pressure level for the night (11 pm–7am). Noise exposures were assigned to subjects according to their annual residential postal codes during the 15‐year follow‐up. We used random‐effect Cox proportional hazards models adjusting for personal and area‐level characteristics. From 2001 to 2015, each interquartile range increase in the equivalent continuous A‐weighted sound pressure level (dBA) for the 24‐hour day (10.0 dBA) was associated with an 8% increase in incident diabetes mellitus (95% CI, 1.07–1.09) and a 2% increase in hypertension (95% CI, 1.01–1.03). We obtained similar estimates with the equivalent continuous A‐weighted sound pressure level for the night (11 pm–7am). These results were robust to all sensitivity analyses conducted, including further adjusting for traffic‐related air pollutants (ultrafine particles and nitrogen dioxide). For both hypertension and diabetes mellitus, we observed stronger associations with the equivalent continuous A‐weighted sound pressure level (dBA) for the 24‐hour day among women and younger adults (aged <60 years).</p>
<p><strong>Conclusions</strong></p>
<p>Long‐term exposure to road traffic noise was associated with an increased incidence of diabetes mellitus and hypertension in Toronto. </p>
Penguatan Numerasi Siswa melalui Model Permainan Rangking 1 di Kabupaten Cianjur
Authors: Septian Ari , Jusniani Nia , Komala Elsa , Inayah Sarah , Erma Erma Monariska , Sugiarni Rani , Setiawan Erwan , Soeleman Soeleman , Darwati Jenudin , Ramadhia H Dinda , Sutandi Andi 
Published: November 2024

Numerasi merupakan kemampuan dasar penting dalam matematika, namun masih banyak siswa yang mengalami kesulitan dalam memahami konsep numerasi secara mendalam, terutama diwilayah Kabupaten Cianjur. Tujuan dari kegiatan ini adalah untuk memberi penguatan numerasi siswa melalui model permainan rangking 1 di kabupaten Cianjur. Kegiatan ini dilaksanakan di Universitas Suryakancana dan diimplementasikan pada siswa SMA/ SMK di Kabupaten Cianjur. Kegiatan ini terdiri dari beberapa fase yaitu pemanasan, kompetisi, diskusi, dan feedback, dengan metode penguatan numerasi yang diterapkan melalui soal-soal numerasi dan permainan interaktif. Siswa diajak untuk menyelesaikan berbagai tantangan numerasi dalam bentuk permainan Rangking 1, yang didesain untuk melatih kemampuan berhitung, logika dan pemahaman konsep matematika secara menyenangkan. Feedback siswa mengindikasikan bahwa metode ini efektif tidak hanya dalam meningkatkan keterlibatan siswa, tetapi juga dalam memperkuat pemahaman numerasi siswa secara umum. Meskipun metode ini efektif dalam menguatkan pemahaman siswa, namun upaya yang lebih luas dan berkelanjutan tetap diperlukan untuk mengatasi rendahnya tingkat numerasi siswa di Indonesia secara keseluruhan.
Dead Mouse
Authors: Fair Carol Christine , Verma Veena 
Published: November 2024

This is a translation of Veena Verma’s (2 September 1960 - present) short story titled "Dead Mouse" for your consideration. This story is part of Verma’s collection of Punjabi-language short stories titled Mul di Tiviin (Bought Woman), which was published in 2015. Mul di Tiviin is a collection of woman-centered short stories narrating the economic, social, and cultural precarity of Punjabi women, both in Punjab and in the diaspora. Veena Verma is an important Punjabi-language short story writer. She resides in the United Kingdom where she works as a social worker. Her stories narrate the challenges and tribulations of Punjabi women trying to navigate the diaspora far from their natal homes in the Punjab, whether in Pakistan or India.
Papel mediador de las redes sociales en la relación entre afrontamiento, ansiedad y depresión en situaciones de emergencia
Authors: Mestas- Hernández Lilia , Gordillo León Fernando , Robles-Aguirre Bernardo , Cordero Juárez Verónica , González López José Eduardo 
Published: November 2024

La sobreutilización de las redes sociales como medio de interaccionar con otras personas durante el COVID-19 podría tener consecuencias negativas para la salud mental en personas con determinados estilos de afrontamiento. El objetivo de la presente investigación fue el de analizar la relación entre afrontamiento, frecuencia de uso de las redes sociales y los niveles de ansiedad y depresión en adultos jóvenes durante la COVID-19. Se realizó un experimento en el que participaron 643 sujetos que completaron unos cuestionarios de afrontamiento (Cuestionario de Afrontamiento del Estrés; SCQ), ansiedad (Inventario de Ansiedad de Beck; BAI) y depresión (Inventario de depresión de Beck; BDI-IA). Además, se tomaron medidas de la frecuencia de uso de las redes sociales (F-RS: 1 hora o menos, 2-3 horas, 4-5 horas, más de 5 horas). Los sujetos que utilizaron con mayor frecuencia las redes sociales (> 5 horas vs < 5 horas) tuvieron mayores niveles de ansiedad, depresión, autofocalización negativa, expresión emocional abierta, y búsqueda de apoyo social. Por otro lado, la F-RS mediaba en la relación entre afrontamiento (autofocalización negativa, expresión emocional abierta, evitación, búsqueda de apoyo social) y los niveles de ansiedad y depresión. Estos resultados advierten del papel mediador negativo de la sobreutilización de las redes sociales en situaciones de emergencia sobre la salud mental, y aporta información relevante para establecer estrategias que permitan regular la intensidad afectiva de la población y mejorar la adherencia a las medidas preventivas.
Cancer immunogenic cell death via pyroptosis with CXCR4-targeted nanotoxins in hepatocellular carcinoma
Authors: Huang Yingbin , Li Yihu , He Rui , Dong Shuyi , Zhao Zheng , Jiao Xingyuan 
Published: November 2024

IntroductionCytotoxic agents have shown limited benefits in hepatocellular carcinoma (HCC), mediated in part by the lack of targeting. As cell-penetrating peptides (CPPs) are capable of delivering various biologically active molecules into cells, including protein, peptides, small chemo-drugs, and nucleic acid with or without targeting, we developed T22-PE24, a CXCR4-targeted self-assembling cytotoxic nanotoxin, to effectively induce HCC pyroptosis.MethodsT22 incorporating enhanced green fluorescent protein (EGFP) or PE24 was purified from DE3 bacterial cells and characterized using transmission electron microscopy, the Zetasizer Nano®, and SEC-HPLC. The internalization effect of T22-EGFP was detected by flow cytometry system (FCS) in CXCR4+/LM3(CXCR4−) HCC cells. The CCK8, lactate dehydrogenase (LDH) release, Western blot, and nude mice HCC models were used to estimate the cell viability of T22-PE24. The complete-immunity HCC tumor-bearing mice model was used to assess the immune response of T22-PE24.ResultsThe round shape under transmission electron microscopy, 49.4 nm hydrodynamic diameter, and −33.33 mV zeta potential indicated that T22-PE24 self-assembled into nanoparticles. T22 incorporating EGFP selectively internalized in CXCR4+ HCC cells and showed no accumulation in CXCR4-knockout HCC cells. The T22-PE24 nanotoxin induced HCC pyroptosis via the caspase-3/GSDME signaling pathway and suppressed tumor growth in the absence of histological alterations in normal organs. Using the complete-immunity HCC tumor-bearing mice model, we found that T22-PE24 nanotoxin effectively induces the global reprogramming of cell components of the immune tumor microenvironment, leading to enhanced antitumor effects compared to those observed in immunodeficient mice.ConclusionOur findings demonstrate the activation of the innate immune response in HCC by inducing pyroptosis with T22-PE24 nanotoxin treatment and support an implementation of this strategy for HCC treatment.
Quadrivalent HPV (4vHPV) vaccine immunogenicity and safety in women using immunosuppressive drugs due to solid organ transplant
Authors: Miyaji Karina Takesaki , Infante Vanessa , Picone Camila Melo , Dillner Joakim , Kann Hanna , Eklund Carina , Levi José Eduardo , de Oliveira Ana Carolina Soares , Lara Amanda Nazareth , Kawakami Lyca Suzuki , Tacla Maricy , Castanheira Cristina Paula , Mayaud Philippe , Sartori Ana Marli Christovam 
Published: November 2024

IntroductionImmunocompromised persons are at high risk of persistent Human Papilloma Virus (HPV) infection and associated diseases. Few studies evaluated HPV vaccines in immunocompromised persons. This study aimed to evaluate the quadrivalent HPV vaccine (4vHPV) immunogenicity and safety in solid organ transplant (SOT) recipients, in comparison to immunocompetent women (IC).MethodsOpen-label clinical trial that enrolled SOT recipients and immunocompetent women aged 18 to 45 years. All participants received three doses of 4vHPV vaccine. Blood samples were drawn for evaluation of immune responses at baseline and one month after the third vaccination. Seroconversion rates and antibody geometric mean concentration (GMC) against HPV 6, 11, 16, 18, 31, 35, 52 and 58 were measured with in-house multiplexed serology assay (xMAP technology). Follow-up for the local and systemic adverse events (AEs) continued for seven days after each vaccination. Severe AEs were evaluated throughout the study.Results125 SOT and 132 immunocompetent women were enrolled; 105 (84%) SOT and 119 (90%) immunocompetent women completed the study. At baseline, HPV seropositivity was not significantly different between groups. Seroconversion rates were significantly lower in SOT (HPV18, 57%; HPV6 and 16, 69%; and HPV11, 72%) than in immunocompetent women (100% seroconversion to all vaccine types) (p&lt;0.001). Antibody GMCs of all four HPV vaccine types were also significantly lower in SOT (p&lt;0.001). Pain in the injection site and headache were the most frequent adverse event in both groups. Local pain was more frequent in immunocompetent women than in SOT recipients. Rates of other AEs were comparable in both groups.Conclusion4vHPV vaccine was well-tolerated by SOT recipients. We found strong evidence of lower humoral immune responses to 4vHPV vaccine in SOT compared to immunocompetent women, which strengthen recommendation of routine cervical cancer screening in SOT recipients regardless of HPV vaccination status.
Hematologic cancers and infections: how to detect infections in advance and determine the type?
Authors: Chen Yan , Ma Tao 
Published: November 2024

Infection is one of the leading causes of death in patients with hematologic cancers. Hematologic cancer patients with compromised immune systems are already susceptible to infections, which come on even more rapidly and are difficult to control after they develop neutrophil deficiencies from high-dose chemotherapy. After patients have developed an infection, the determination of the type of infection becomes a priority for clinicians. In this review, we summarize the biomarkers currently used for the prediction of infections in patients with hematologic cancers; procalcitonin, CD64, cytokines, and CD14 et al. can be used to determine bacterial infections, and (1-3)-β-D-glucan and galactomannan et al. can be used as a determination of fungal infections. We have also focused on the use of metagenomic next-generation sequencing in infections in patients with hematologic cancers, which has excellent clinical value in infection prediction and can detect microorganisms that cannot be detected by conventional testing methods such as blood cultures. Of course, we also focused on infection biomarkers that are not yet used in blood cancer patients but could be used as a future research direction, e.g., human neutrophil lipocalin, serum amyloid A, and heparin-binding protein et al. Finally, clinicians need to combine multiple infection biomarkers, the patient’s clinical condition, local susceptibility to the type of infection, and many other factors to make a determination of the type of infection.
Application of tongue image characteristics and oral-gut microbiota in predicting pre-diabetes and type 2 diabetes with machine learning
Authors: Deng Jialin , Dai Shixuan , Liu Shi , Tu Liping , Cui Ji , Hu Xiaojuan , Qiu Xipeng , Jiang Tao , Xu Jiatuo 
Published: November 2024

BackgroundThis study aimed to characterize the oral and gut microbiota in prediabetes mellitus (Pre-DM) and type 2 diabetes mellitus (T2DM) patients while exploring the association between tongue manifestations and the oral-gut microbiota axis in diabetes progression.MethodsParticipants included 30 Pre-DM patients, 37 individuals with T2DM, and 28 healthy controls. Tongue images and oral/fecal samples were analyzed using image processing and 16S rRNA sequencing. Machine learning techniques, including support vector machine (SVM), random forest, gradient boosting, adaptive boosting, and K-nearest neighbors, were applied to integrate tongue image data with microbiota profiles to construct predictive models for Pre-DM and T2DM classification.ResultsSignificant shifts in tongue characteristics were identified during the progression from Pre-DM to T2DM. Elevated Firmicutes levels along the oral-gut axis were associated with white greasy fur, indicative of underlying metabolic changes. An SVM-based predictive model demonstrated an accuracy of 78.9%, with an AUC of 86.9%. Notably, tongue image parameters (TB-a, perALL) and specific microbiota (Escherichia, Porphyromonas-A) emerged as prominent diagnostic markers for Pre-DM and T2DM.ConclusionThe integration of tongue diagnosis with microbiome analysis reveals distinct tongue features and microbial markers. This approach significantly improves the diagnostic capability for Pre-DM and T2DM.
Navigating constraints: news values and journalistic role performance in Chinese state media VR news
Authors: Zhou Yongyuan 
Published: November 2024

IntroductionThis study explores the intersection of virtual reality (VR) technology and journalism, with a particular focus on the application of VR in news productions by China Central Television (CCTV). The research aims to assess how VR enhances immersive storytelling, the prevailing news values it supports, and how journalistic roles are performed within these productions in China.MethodsA content analysis was conducted on 234 VR news productions by CCTV, examining the use of immersive elements, the representation of news values, and the roles of journalists in the context of VR news.ResultsThe findings indicate that, while VR enhances audience engagement through immersive experiences, its application in CCTV’s VR news remains limited in scope. The technology is primarily employed within traditional journalistic frameworks, often emphasizing the loyal-facilitator role.DiscussionThe study reveals that immersive journalism at CCTV tends to support state-aligned narratives, promoting positive news values and limiting the critical engagement typically associated with more interventionist journalistic models. By examining the news values and the nuanced performances of journalistic roles in the context of VR news, this research contributes to the broader understanding of how emerging technologies like VR are shaping journalistic practices in authoritarian media systems, offering insights into both the potential and limitations of VR in enhancing audience engagement while maintaining journalistic integrity.