bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward personalized treatment in multiple myeloma based on molecular characteristics
Authors: Pawlyn Charlotte , Davies Faith E. 
Published: December 2018

AbstractTo date, the choice of therapy for an individual multiple myeloma patient has been based on clinical factors such as age and comorbidities. The widespread evolution, validation, and clinical utilization of molecular technologies, such as fluorescence in situ hybridization and next-generation sequencing has enabled the identification of a number of prognostic and predictive biomarkers for progression-free survival, overall survival, and treatment response. In this review, we argue that in order to continue to improve myeloma patient outcomes incorporating such biomarkers into the routine diagnostic workup of patients will allow for the use of personalized, biologically based treatments.
Exosomal regulation of lymphocyte homing to the gut
Authors: Park Eun Jeong , Prajuabjinda Onmanee , Soe Zay Yar , Darkwah Samuel , Appiah Michael G. , Kawamoto Eiji , Momose Fumiyasu , Shiku Hiroshi , Shimaoka Motomu 
Published: December 2018

AbstractExosomes secreted from T cells have been shown to affect dendritic cells, cancer cells, and other T cells. However, little is known about how T-cell exosomes (T exosomes) modulate endothelial cell functions in the context of tissue-specific homing. Here, we study the roles of T exosomes in the regulation of gut-specific T-cell homing. The gut-tropic T cells induced by retinoic acid secrete the exosomes that upregulate integrin α4β7 binding to the MAdCAM-1 expressed on high endothelial venules in the gut. T exosomes were preferentially distributed to the villi of the small intestine in an α4β7-dependent manner. Exosomes from gut-tropic T cells suppressed the expression of MAdCAM-1 in the small intestine, thereby inhibiting T-cell homing to the gut. Moreover, microRNA (miRNA) profiling analysis has shown that exosomes from gut-tropic T cells were enriched with miRNAs targeting NKX2.3, a transcription factor critical to MAdCAM-1 expression. Taken together, our study proposes that α4β7-expressing T exosomes distribute themselves to the small intestine and modify the expression of microenvironmental tissues such that any subsequent lymphocyte homing is precluded. This may represent a novel mechanism by which excessive lymphocyte homing to the intestinal tissues is downsized.
Nosocomial outbreak of multi-resistant Streptococcus pneumoniae serotype 15A in a centre for chronic pulmonary diseases
Authors: Bastiaens Guido J. H. , Cremers Amelieke J. H. , Coolen Jordy P. M. , Nillesen Mayke T. , Boeree Martin J. , Hopman Joost , Wertheim Heiman F. L. 
Published: December 2018

AbstractWe report nosocomial transmission of multi-resistant serotype 15A Streptococcus pneumoniae (MRSP) that resulted in two lower respiratory tract infections in a centre for chronic pulmonary diseases. This outbreak highlights the potential for transmission of MRSP among vulnerable patients when laboratory turnaround time is long and patient compliance with transmission-based precautions is low.
Neoadjuvant Degarelix Versus Triptorelin in Premenopausal Patients Who Receive Letrozole for Locally Advanced Endocrine-Responsive Breast Cancer: A Randomized Phase II Trial
Authors: Dellapasqua Silvia , Gray Kathryn P. , Munzone Elisabetta , Rubino Daniela , Gianni Lorenzo , Johansson Harriet , Viale Giuseppe , Ribi Karin , Bernhard Jürg , Kammler Roswitha , Maibach Rudolf , Rabaglio-Poretti Manuela , Ruepp Barbara , Di Leo Angelo , Coates Alan S. , Gelber Richard D. , Regan Meredith M. , Goldhirsch Aron , Colleoni Marco ,   for the International Breast Cancer Study Group
Published: December 2018

PURPOSE To evaluate endocrine activity in terms of ovarian function suppression (OFS) of degarelix (a gonadotropin-releasing hormone [GnRH] antagonist) versus triptorelin (a GnRH agonist) in premenopausal patients receiving letrozole as neoadjuvant endocrine therapy for breast cancer. PATIENTS AND METHODS Premenopausal women with stage cT2 to 4b, any N, M0; estrogen receptor and progesterone receptor greater than 50%; human epidermal growth factor receptor 2–negative breast cancer were randomly assigned to triptorelin 3.75 mg administered intramuscularly on day 1 of every cycle or degarelix 240 mg administered subcutaneously (SC) on day 1 of cycle 1 then 80 mg SC on day 1 of cycles 2 through 6, both with letrozole 2.5 mg/day for six 28-day cycles. Surgery was performed 2 to 3 weeks after the last injection. Serum was collected at baseline, after 24 and 72 hours, at 7 and 14 days, and then before injections on cycles 2 through 6. The primary end point was time to optimal OFS (time from the first injection to first assessment of centrally assessed estradiol level ≤ 2.72 pg/mL [≤ 10 pmol/L] during neoadjuvant therapy). The trial had 90% power to detect a difference using a log-rank test with a two-sided α of .05. Secondary end points included response, tolerability, and patient-reported endocrine symptoms. RESULTS Between February 2014 and January 2017, 51 patients were enrolled (n = 26 received triptorelin plus letrozole; n = 25 received degarelix plus letrozole). Time to optimal OFS was three times faster for patients assigned to degarelix and letrozole than to triptorelin and letrozole (median, 3 v 14 days; hazard ratio, 3.05; 95% CI, 1.65 to 5.65; P < .001). Furthermore, OFS was maintained during subsequent cycles for all patients assigned to receive degarelix and letrozole, whereas 15.4% of patients assigned to receive triptorelin and letrozole had suboptimal OFS after cycle 1 (six events during 127 measurements). Adverse events as a result of both degarelix plus letrozole and triptorelin plus letrozole were as expected. CONCLUSION In premenopausal women receiving letrozole for neoadjuvant endocrine therapy, OFS was achieved more quickly and maintained more effectively with degarelix than with triptorelin.
Barriers and Opportunities of Oncofertility Practice in Nine Developing Countries and the Emerging Oncofertility Professional Engagement Network
Authors: Salama Mahmoud , Ataman-Millhouse Lauren , Sobral Fabio , Terrado Guillermo , Scarella Anibal , Bourlon Maria T. , Adiga Satish Kumar , Udupa Karthik S. , Mahajan Nalini , Patil Madhuri , Venter Chris , Demetriou Georgia , Quintana Ramiro , Rodriguez Gabriela , Quintana Tomas , Viale Luz , Bonilla Yuly Andrea Remolina , Noguera July Andrea Russi , Velásquez Juan Carlos Velásquez , Pineda Jennifer Ivonne Dominguez , Aldecoa Mario Daniel Castro , Javed Murid , Al Sufyan Hamad , Daniels Nonso , Ogunmokun Adegbite A. , Woodruff Teresa K. 
Published: December 2018

PURPOSE Oncofertility practice continues to grow in developing countries despite the lack of health care services, especially those related to cancer care. The purpose of this study is to further explore oncofertility practice in these countries and identify opportunities for field-wide coalescence. METHODS We generated a survey to learn more about oncofertility practice in nine developing countries within our Oncofertility Consortium Global Partners Network—Mexico, Colombia, Guatemala, Argentina, Chile, Nigeria, South Africa, Saudi Arabia, and India. Their responses were collected, reviewed, and discussed. RESULTS Surveyed centers from the nine developing countries continue to experience a similar set of common challenges, including a lack of awareness among providers and patients, cultural and religious constraints, lack of insurance coverage and funding to help to support oncofertility programs, and high out-of-pocket costs for patients. Despite these barriers, many opportunities exist and there is great potential for the future. CONCLUSION The current need is to unify the new technologies and best practices that emerge from rural communities and developing countries with those in large metropolitan cities, both domestically (US based) and abroad, into a functional unit: the Oncofertility Professional Engagement Network. The Oncofertility Professional Engagement Network will bridge the gap between domestic and international programs to establish a strong global network in which members share resources, methodologies and experiences and further build cultural competency.
Hydrosilylation of Diene Derivatives Catalyzed by Fe-Iminobipyridine Complexes Aiming at Syntheses of Organosilane Compounds Containing a Terminal Olefin Portion
Authors: Kobayashi Katsuaki , Teratani Sayaka , Izumori Yosuke , Hayasaka Kazumasa , Nakazawa Hiroshi 
Published: December 2018

Abstract
The catalytic ability of Fe-iminobipyridine complexes ((BPI)FeBr2, BPI = iminobipyridine) for hydrosilylation of both a non-conjugated diene and a conjugated diene was investigated aiming at the production of organosilane compounds bearing a terminal olefin portion. Steric effects of (BPI)FeBr2 were controlled by the substituents at the terminal pyridine ring (R1), the imino carbon (R2), and the imino nitrogen (Ar) of the BPI ligand. As regards a non-conjugated diene, hydrosilylation of 1,7-octadiene with diphenylsilane (Ph2SiH2) produced a mixture of mono- and di-hydrosilylated compounds. To obtain the mono-hydrosilylated compound preferably in the 1:1 reaction of non-conjugated diene and silane, the substituent effect of the BPI ligand was investigated. As a result, larger steric hindrance of (BPI)FeBr2 based on substituents slowed the hydrosilylation, instead the selectivity of the mono-hydrosilylated compound was substantially improved. The 6′-Me group on a terminal pyridine was most effective. Finally, production of the mono-hydrosilylated compound from 1,7-octadiene and Ph2SiH2 reached 77% yield and 0.94 selectivity. In the case of a conjugated diene, (BPI)FeBr2 with any substituents selectively generated 1,4-hydrosilylated compound in hydrosilylation of 2,3-dimethyl-1,3-butadiene with Ph2SiH2. In this case, higher steric hindrance of (BPI)FeBr2 simply decreased the yield of the product.
pQCT- and Ultrasound-based Muscle and Fat Estimate Errors after Resistance Exercise
Authors: ROWE GRANT SIMON , BLAZEVICH ANTHONY J. , HAFF G. GREGORY 
Published: December 2018

ABSTRACT

Purpose
Resistance exercise increases blood flow, induces osmotic and hydrostatic fluid shifts during and immediately after exercise, and may trigger inflammatory responses for several days in the working muscle. The resultant muscle swelling can subsequently affect muscle size and quality assessments. However, the effects of muscle swelling on x-ray attenuation of adipose estimate errors are unknown.

Methods
Peripheral quantitative computed tomography (pQCT) and ultrasonography were used to assess muscle and adipose tissue properties of both upper arms before, 24, 48, and 72 h after unilateral resistance exercise. Recreationally active participants (n = 17) completed the exercise while their contralateral limb served as a control.

Results
Resistance exercise resulted in a significant increase in pQCT-derived muscle cross-sectional area (includes intermuscular adipose tissue [IMAT] area), muscle area (excludes IMAT area) and IMAT area, and ultrasound-derived muscle thickness at 24, 48, and 72 h. A significant decrease in pQCT-derived muscle density was also detected as well as an increase in ultrasound-derived echo intensity at 48 and 72 h. The changes in muscle area, IMAT area, and muscle density were significantly correlated with changes in echo intensity, whereas the changes in muscle cross-sectional area and IMAT area were significantly correlated with changes in muscle thickness.

Conclusion
Unaccustomed resistance exercise can cause errors in pQCT- and ultrasound-based muscle and adipose estimates for at least 72 h. These errors are the result of muscle swelling likely caused by muscle blood flow and inflammation-dependent fluid shifts in muscle. These findings may have implications for measurements in other inflammatory conditions.
Agility Comparison of Stabilizer and Direct Head Systems Mounted on an Unmanned Agricultural Helicopter
Authors: Shim Sung Bo , Bae Yeonghwan , Koo Young Mo 
Published: December 2018

Abstract. Recently, there has been increasing interest in using unmanned aerial vehicles (UAVs) to reduce the labor required for pest control and to protect farmers from exposure to pesticides. Unmanned aerial application has become a new paradigm in pesticide application; however, a uniform speed must be maintained within a short accelerating distance when spraying small plots, and this depends on the skill of the operator, which is difficult to rely on. In this study, the agility of a direct head system mounted on an unmanned agricultural helicopter was compared with that of a conventional stabilizer head system by using a pitch sweep test in CIFER, a dynamic analysis software program. The controllable frequency range of the unmanned agricultural helicopter with the direct head was analyzed to range between 0.06 and 5 Hz, and the responsiveness of the helicopter with the conventional stabilizer head was observed in a relatively low frequency range of 0.06 to 1.6 Hz. In addition, in comparing the equivalent time delay between the representative transfer functions from the pitch direction input to the surge acceleration obtained using NAVFIT analysis, the time delay of the direct head was shorter than that of the stabilizer head, although the extent of the enhancement was not satisfactory because of the tail gyroscope used for intrinsic attitude stability. Keywords: Agility, Agricultural unmanned helicopter, CIFER, Flight dynamics, Swash head system.
Energy and Economic Analysis for Greenhouse Envelope Design
Authors: Bambara James , Athienitis Andreas K. 
Published: December 2018

Abstract. The energy consumption of a building is significantly impacted by its envelope design, particularly for greenhouses where coverings typically provide high heat and daylight transmission. Energy and life cycle cost (LCC) analysis were used to identify the most cost-effective cladding design for a greenhouse located in Ottawa, Ontario, Canada (45.4° N) that employs supplemental lighting. The base case envelope design uses single glazing, whereas the two alternative designs consist of replacing the glass with twin-wall polycarbonate and adding foil-faced rigid insulation (permanent or movable) on the interior surface of the glass. All the alternative envelope designs increased electricity consumption for lighting and decreased heating energy use except when permanent or movable insulation was applied to the north wall and in the case of permanent insulation on the north wall plus polycarbonate on the east wall. This demonstrates how the use of reflective opaque insulation on the north wall can be beneficial for redirecting light onto the crops to achieve simultaneous reductions in electricity and heating energy costs. A maximum reduction in LCC of 5.5% (net savings of approximately $130,000) was achieved when permanent insulation was applied to the north and east walls plus polycarbonate on the west wall. This alternative envelope design increased electricity consumption for horticultural lighting by 4.3%, reduced heating energy use by 15.6%, and caused greenhouse gas emissions related to energy consumption to decrease by 14.7%. This analysis demonstrates how energy and economic analysis can be employed to determine the most suitable envelope design based on local climate and economic conditions. Keywords: Artificial lighting, Consistent daily light integral, Energy modeling, Envelope design, Greenhouse, Life cycle cost analysis, Light emitting diode, Local agriculture.
National Innovation Capability Variables and Dimensions
Authors: Gunadi Ahmad Dading , Arkeman Yandra , Nazli Rizal Syarief Siaiful , Rahardjo Teguh , Wachjudiningsih Aulijati 
Published: December 2018

<p><span style="font-size: medium;"><span style="font-family: Times New Roman;">The purpose of this paper is to analyze the dimensions and variables of National Innovation Capability. The findings in this paper are to refine the National Innovation Capabilities Dimension model developed by Chang and Lin (2012) by integrating a Network Dimension of Innovation. This paper analyzes the dimensions and variables of National Innovation Capability through a system approach that includes Input Sub System, Process Sub System, and Output Sub System. Network Dimensions Innovation is an integral part of the National Innovation Capabilities Dimension. This dimension is an important part, because the National Innovation Capability will largely depend on how innovative actors form networks and interact among them. The dimensions of National Innovation Capability are integrated into three sub system in a systems approach that includes input, process, and output. In the input consists of Dimensions of Innovation Resources. In the process consists of Innovation Demand Dimension, Innovation Network Dimension and Innovation Diffusion Dimension. In the output consists of Dimensions of Innovation Output. Each Dimension has some different variables. The entire dimensions and variables of these three sub system become unified as a Dimension and Variable of National Innovation Capability.</span></span></p><p> </p><strong>Keywords</strong>: National Innovation Capability, Dimensions, Variables, Sub Systems
Selective Strengthening of Intracortical Excitatory Input Leads to Receptive Field Refinement during Auditory Cortical Development
Authors: Sun Yujiao J. , Liu Bao-hua , Tao Huizhong W. , Zhang Li I. 
Published: December 2018

In the primary auditory cortex (A1) of rats, refinement of excitatory input to layer (L)4 neurons contributes to the sharpening of their frequency selectivity during postnatal development. L4 neurons receive both feedforward thalamocortical and recurrent intracortical inputs, but how potential developmental changes of each component can account for the sharpening of excitatory input tuning remains unclear. By combiningin vivowhole-cell recording and pharmacological silencing of cortical spiking in young rats of both sexes, we examined developmental changes at three hierarchical stages: output of auditory thalamic neurons, thalamocortical input and recurrent excitatory input to an A1 L4 neuron. In the thalamus, the tonotopic map matured with an expanded range of frequency representations, while the frequency tuning of output responses was unchanged. On the other hand, the tuning shape of both thalamocortical and intracortical excitatory inputs to a L4 neuron became sharpened. In particular, the intracortical input became better tuned than thalamocortical excitation. Moreover, the weight of intracortical excitation around the optimal frequency was selectively strengthened, resulting in a dominant role of intracortical excitation in defining the total excitatory input tuning. Our modeling work further demonstrates that the frequency-selective strengthening of local recurrent excitatory connections plays a major role in the refinement of excitatory input tuning of L4 neurons.SIGNIFICANCE STATEMENTDuring postnatal development, sensory cortex undergoes functional refinement, through which the size of sensory receptive field is reduced. In the rat primary auditory cortex, such refinement in layer (L)4 is mainly attributed to improved selectivity of excitatory input a L4 neuron receives. In this study, we further examined three stages along the hierarchical neural pathway where excitatory input refinement might occur. We found that developmental refinement takes place at both thalamocortical and intracortical circuit levels, but not at the thalamic output level. Together with modeling results, we revealed that the optimal-frequency-selective strengthening of intracortical excitation plays a dominant role in the refinement of excitatory input tuning.
Corruption and Government Intervention on Bank Risk-Taking: Cases of Asian Countries
Authors: Nurhidayat Rizky Maulana , Rokhim Rofikoh 
Published: December 2018

This paper aims to addresses the impact of corruption, anti-corruption commission, and government intervention on bank’s risk-taking using banks in Asian Countries such as Indonesia, Malaysia, Thailand, and South of Korea during the period 1995-2016. This paper uses corruption variable, bank-specific variables, macroeconomic variables, dummy variables and interaction variable to estimate bank’s risk-taking variable. Using data from 76 banks in Indonesia, Malaysia, Thailand and South Korea over 21 years, this research finds consistent evidence that higher level of corruption and government intervention in crisis-situation will increase the risk-taking behaviour of banks. In the other hand, bank risk-taking behaviour minimized by the existence of anti-corruption commission. In addition, this paper also finds that government intervention amplifies corruption’s effect on bank’s risk-taking behaviour because of strong signs of moral hazard and weaknesses in the governance and supervision.
Unifying stylistic syntheses in the late compositions (1939–1945) of Béla Bartók
Authors: Josephson Nors S. 
Published: December 2018

Bartók’s later works from the years 1939–1945 present an impressive synthesis of his musical innovations. Beginning with the Divertimento and Sixth String Quartet (both composed in 1939), the Hungarian composer starts with a freely tonal, neo-Classical foundation. Above this initial compositional level he then superimposes Beethovenian formal structures gleaned from the latter’s opp. 53 and 135, in addition to a prominent Stravinsky quotation from The Rite of Spring, part two. In both works Bartók achieves an impressive large-scale cyclical unity, frequently through wholetone scalar integration.
The Concerto for Orchestra (1943) blends pervasive quotation techniques with analogous cyclical intervallic patterns, such as major third cells on F–A–D4. One is again distinctly reminded of the F Major Divertimento. Like the latter work, the Concerto is especially notable for its expansive codas, which function in the manner of Beethovenian second developments. Similarly, the Sonata for Solo Violin (1944) fuses neo-Bachian counterpoint with the expansive forms of the Concerto for Orchestra. Finally, the interrelated last two Concertos for piano and viola (both penned in 1945) present a cumulative synthesis of Bartókʼs later style, emphasizing the tertial (and modal) degrees of VI and flattened VI. Here, too, we encounter elaborate quotational systems that distantly recall the 1910s and 1920s music of French composers as Debussy, Ravel and Satie.