bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis
Authors: Takahashi Kentaro , Pavlidis Stelios , Ng Kee Kwong Francois , Hoda Uruj , Rossios Christos , Sun Kai , Loza Matthew , Baribaud Fred , Chanez Pascal , Fowler Steve J. , Horvath Ildiko , Montuschi Paolo , Singer Florian , Musial Jacek , Dahlen Barbro , Dahlen Sven-Eric , Krug Norbert , Sandstrom Thomas , Shaw Dominic E. , Lutter Rene , Bakke Per , Fleming Louise J. , Howarth Peter H. , Caruso Massimo , Sousa Ana R. , Corfield Julie , Auffray Charles , De Meulder Bertrand , Lefaudeux Diane , Djukanovic Ratko , Sterk Peter J. , Guo Yike , Adcock Ian M. , Chung Kian Fan 
Published: April 2018

Severe asthma patients with a significant smoking history have airflow obstruction with reported neutrophilia. We hypothesise that multi-omic analysis will enable the definition of smoking and ex-smoking severe asthma molecular phenotypes.The U-BIOPRED cohort of severe asthma patients, containing current-smokers (CSA), ex-smokers (ESA), nonsmokers and healthy nonsmokers was examined. Blood and sputum cell counts, fractional exhaled nitric oxide and spirometry were obtained. Exploratory proteomic analysis of sputum supernatants and transcriptomic analysis of bronchial brushings, biopsies and sputum cells was performed.Colony-stimulating factor (CSF)2 protein levels were increased in CSA sputum supernatants, with azurocidin 1, neutrophil elastase and CXCL8 upregulated in ESA. Phagocytosis and innate immune pathways were associated with neutrophilic inflammation in ESA. Gene set variation analysis of bronchial epithelial cell transcriptome from CSA showed enrichment of xenobiotic metabolism, oxidative stress and endoplasmic reticulum stress compared to other groups. CXCL5 and matrix metallopeptidase 12 genes were upregulated in ESA and the epithelial protective genes, mucin 2 and cystatin SN, were downregulated.Despite little difference in clinical characteristics, CSA were distinguishable from ESA subjects at the sputum proteomic level, with CSA patients having increased CSF2 expression and ESA patients showing sustained loss of epithelial barrier processes.
In vivo growth of 60 non-screening detected lung cancers: a computed tomography study
Authors: Mets Onno M. , Chung Kaman , Zanen Pieter , Scholten Ernst T. , Veldhuis Wouter B. , van Ginneken Bram , Prokop Mathias , Schaefer-Prokop Cornelia M. , de Jong Pim A. 
Published: April 2018

Current pulmonary nodule management guidelines are based on nodule volume doubling time, which assumes exponential growth behaviour. However, this is a theory that has never been validated in vivo in the routine-care target population. This study evaluates growth patterns of untreated solid and subsolid lung cancers of various histologies in a non-screening setting.Growth behaviour of pathology-proven lung cancers from two academic centres that were imaged at least three times before diagnosis (n=60) was analysed using dedicated software. Random-intercept random-slope mixed-models analysis was applied to test which growth pattern most accurately described lung cancer growth. Individual growth curves were plotted per pathology subgroup and nodule type.We confirmed that growth in both subsolid and solid lung cancers is best explained by an exponential model. However, subsolid lesions generally progress slower than solid ones. Baseline lesion volume was not related to growth, indicating that smaller lesions do not grow slower compared to larger ones.By showing that lung cancer conforms to exponential growth we provide the first experimental basis in the routine-care setting for the assumption made in volume doubling time analysis.
Colonization sites in carriers of ESBL-producing Gram-negative bacteria
Authors: van Prehn Joffrey , Kaiser Anna M. , van der Werff Suzanne D. , van Mansfeld Rosa , Vandenbroucke-Grauls Christina M. J. E. 
Published: April 2018

Abstract
Objective
The distribution of Extended-Spectrum Beta-Lactamase-producing Gram-negative bacteria (ESBL-GNB) colonization sites is relevant for infection control guidelines on detection and follow-up of colonization. We questioned whether it is possible to rely solely on rectal swab culture for follow-up of ESBL-GNB colonization.

Methods
We retrospectively assessed ESBL-GNB colonization sites in patients in a tertiary hospital in the Netherlands. The Laboratory Information Management System was queried for all bacterial cultures obtained between January 2012 and August 2016. All patients with one or more cultures positive for ESBL-GNB were identified and the distribution of ESBL-GNB positive sample sites was assessed. A subgroup analysis was performed on patients for whom at least one rectal swab specimen was available.

Results
We identified 1011 ESBL-GNB carriers with 16,578 specimens for analysis. ESBL-GNB were most frequently isolated from the rectum (506/1011), followed by the urogenital (414/1011) and respiratory tract (142/1011), and pus (136/1011). For 588 patients at least one rectal swab specimen was available. In this subgroup, ESBL-GNB colonization was detected only in the rectum in 55.4% (326/588) of patients, in 30.6% (180/588) in the rectum and a different culture site, and in 13.9% (82/588) no rectal colonization was detected.

Conclusions
Rectal colonization with ESBL-GNB was detected in 86% of ESBL-GNB carriers. However, in 14% of ESBL-GNB carriers we did not detect rectal colonization. Therefore, samples taken for follow-up of colonization with multi-drug resistant Gram-negative bacteria (MDR-GNB) should ideally also include samples from the site where the MDR-GNB was initially found.
Impact on Oncology Practices of Including Drug Costs in Bundled Payments
Authors: Ward Jeffery C. , Levit Laura A. , Page Ray D. , Hennessy John E. , Cox John V. , Kamin Deborah Y. , Bruinooge Suanna S. , Shih Ya-Chen Tina , Polite Blase N. 
Published: April 2018

Introduction: This analysis evaluates the impact of bundling drug costs into a hypothetic bundled payment. Methods: An economic model was created for patient vignettes from: advanced-stage III colon cancer and metastatic non–small-cell lung cancer. First quarter 2016 Medicare reimbursement rates were used to calculate the average fee-for-service (FFS) reimbursement for these vignettes. The probabilistic risk faced by practices was captured by the type of patients seen in practices and randomly assigned in a Monte Carlo simulation on the basis of the given distribution of patient types within each cancer. Simulations were replicated 1,000 times. The impact of bundled payments that include drug costs for various practice sizes and cancer types was quantified as the probability of incurring a loss at four magnitudes: any loss, > 10%, > 20%, or > 30%. A loss was defined as receiving revenue from the bundle that was less than what the practice would have received under FFS; the probability of loss was calculated on the basis of the number of times a practice reported a loss among the 1,000 simulations. Results: Practices that treat a substantial proportion of patients with complex disease compared with the average patient in the bundle would have revenue well below that expected from FFS. Practices that treat a disproportionate share of patients with less complex disease, as compared with the average patient in the bundle, would have revenue well above the revenue under FFS. Overall, bundled payments put practices at greater risk than FFS because their patient case mix could greatly skew financial performance. Conclusion: Including drug costs in a bundle is subject to the uncontrollable probabilistic risk of patient case mixes.
Pain and Its Long-term Interference of Daily Life After Critical Illness
Authors: Hayhurst Christina J. , Jackson Jim C. , Archer Kristin R. , Thompson Jennifer L. , Chandrasekhar Rameela , Hughes Christopher G. 
Published: April 2018

BACKGROUND:
Persistent pain likely interferes with quality of life in survivors of critical illness, but data are limited on its prevalence and risk factors. We sought to determine the prevalence of persistent pain after critical illness and its interference with daily life. Additionally, we sought to determine if intensive care unit (ICU) opioid exposure is a risk factor for its development.

METHODS:
In a cohort of adult medical and surgical ICU survivors, we used the brief pain inventory (BPI) to assess pain intensity and pain interference of daily life at 3 and 12 months after hospital discharge. We used proportional odds logistic regression with Bonferroni correction to evaluate the independent association of ICU opioid exposure with BPI scores, adjusting for potential confounders including age, preadmission opioid use, frailty, surgery, severity of illness, and durations of delirium and sepsis while in the ICU.

RESULTS:
We obtained BPI outcomes in 295 patients overall. At 3 and 12 months, 77% and 74% of patients reported persistent pain symptoms, respectively. The median (interquartile range) pain intensity score was 3 (1, 5) at both 3 and 12 months. Pain interference with daily life was reported in 59% and 62% of patients at 3 and 12 months, respectively. The median overall pain interference score was 2 (0, 5) at both 3 and 12 months. ICU opioid exposure was not associated with increased pain intensity at 3 months (odds ratio [OR; 95% confidence interval], 2.12 [0.92–4.93]; P = .18) or 12 months (OR, 2.58 [1.26–5.29]; P = .04). ICU opioid exposure was not associated with increased pain interference of daily life at 3 months (OR, 1.48 [0.65–3.38]; P = .64) or 12 months (OR, 1.46 [0.72–2.96]; P = .58).

CONCLUSIONS:
Persistent pain is prevalent after critical illness and frequently interferes with daily life. Increased ICU opioid exposure was not associated with worse pain symptoms. Further studies are needed to identify modifiable risk factors for persistent pain in the critically ill and the effects of ICU opioids on patients with and without chronic pain.
HUBUNGAN ANTARA KEBIASAAN MEMBACA ASMAUL HUSNA DENGAN KECERDASAN EMOSIONAL SISWA KELAS XI MA NURUL UMMAH YOGYAKARTA
Authors: Khoirunnisa Lili 
Published: April 2018

This research aims to describe emotional quotient and reading habit of asmaul husna of students and to examine relationship between of both. The subject of this research were all of students in grade XI MA (Senior High School) Nurul Ummah Yogyakarta as many as 34 people. Interviews, scale of emotional quotient, and reading habit asmaul husna questionnaire are used as an instrument in data collection. The results show: first, level of emotional quotient of students in grade XI MA Nurul Ummah Yogyakarta are in the high category. Second, level of reading habit asmaul husna of students in grade XI MA Nurul Ummah Yogyakarta are in the high category. Third, there’s positive and significant correlation (rxy=0,614, p=0,001) between reading habit of asmaul husna and emotional quotient of students in grade XI MA Nurul Ummah Yogyakarta. Fourth, the contribution of reading habit Asmaul Husna toward emotional quotient of students in grade XI MA Nurul Ummah Yogyakarta is 37,70%.

Keywords: reading habit asmaul husna, emotional quotient, student grade XI
SELF REGULATED LEARNING DALAM AL-QUR’AN
Authors: Aziz Jamil Abdul 
Published: April 2018

Self regulated learning is one key to obtaining maximum learning results. However, the facts on the ground are still many students who do not have the independence in learning. Based on this background, it becomes important for every educator and activist education to understand what is the meaning of independent learning, independent learning forms, as well as how to foster independent learning in self-learners.This type of research is the study of literature (libraryresearch). The approach used in this study is the approach of Psychological Sciences. After conducting a study on the independence of existing learning the Koran and Psychology, found some of the following: a) the Koran a lot of gesturing order mankind always read and explore science departing from the awareness and willingness of individuals themselves (QS. [2]: 189, [QS. [8]: 1, [17]: 85) b) forms of learning kemandrian exemplified in al- Koran contained in the story of Moses and Ibrahim (QS. [6]: 76-79). In Psychology, form independent learning contained in Prophet Moses and Nabi Ibrahim belong to the kind Identivied regulation and Intrinsically motivated behavior c) how to cultivate independent learning in the Koran there are: 1) Introduce learners of reality (environment) 2) Build kontsruk think learners
Keywords: Self Regulated Learning, The Qur’an.
PENGARUH HIDDEN CURRICULUM TERHADAP PEMBENTUKAN KARAKTER SISWA DI SMP IT MASJID SYUHADA’ KOTABARU YOGYAKARTA
Authors: Pratiwi Esti Rahmah 
Published: April 2018

Character building for student should be applied in the early age. It is important because early age is the crucial time for student to develop their potential ability. The purpose of this research is to determine the real form of character building through hidden curriculum theory. The research uses a quantitative method. The results showed that: 1) the implementation of the hidden curriculum in SMP IT (integrated Islamic of junior high school) Masjid Syuhada belong in a good category. With the highest percentage value of 29.54%, the group score indicates as good criteria. 2) Character building in the 2 grade of SMP IT (integrated Islamic of junior high school) Masjid Syuhada categorized as good enough, with the highest percentage value of 27, 28%. The group score indicates as good enough criteria. 3) There is a positive and significant influence of hidden curriculum in the student's character, as if the score of hidden curriculum increased by 0.649. Hidden curriculum influence 52.7% in student’s characteristic, while 47.3% are influenced by other factors.
On the Wasserstein distance between mutually singular measures
Authors: Buttazzo Giuseppe , Carlier Guillaume , Laborde Maxime 
Published: April 2018

Abstract
We study the Wasserstein distance between two measures

μ
,
ν

{\mu,\nu}

which are mutually singular. In particular, we are interested in minimization problems of the form

W
⁢

(
μ
,
𝒜
)

=

inf
⁡

{

W
⁢

(
μ
,
ν
)

:

ν
∈
𝒜

}

,

W(\mu,\mathcal{A})=\inf\{W(\mu,\nu):\nu\in\mathcal{A}\},

where μ is a given probability and

𝒜

{\mathcal{A}}

is contained in the class

μ
⊥

{\mu^{\perp}}

of probabilities that are singular with respect to μ. Several cases for

𝒜

{\mathcal{A}}

are considered; in particular, when

𝒜

{\mathcal{A}}

consists of

L
1

{L^{1}}

densities bounded by a constant, the optimal solution is given by the characteristic function of a domain. Some regularity properties of these optimal domains are also studied. Some numerical simulations are included, as well as the double minimization problem

min
⁡

{

P
⁢

(
B
)

+

k
⁢
W
⁢

(
A
,
B
)

:

|

A
∩
B

|

=
0

,

|
A
|

=

|
B
|

=
1

}

,

\min\{P(B)+kW(A,B):|A\cap B|=0,\,|A|=|B|=1\},

where

k
>
0

{k>0}

is a fixed constant,

P
⁢

(
A
)

{P(A)}

is the perimeter of A, and both sets

A
,
B

{A,B}

may vary.
Corporate Criminal Liability in Indonesia Anti-Corruption Law: Does It Work Properly?
Authors: Wibisana Andri Gunawan , Marbun Andreas Nathaniel 
Published: April 2018

Abstract
Since the way of doing corruption has evolved over time, there are likely possibilities for corporate entities to be involved in corruption activities and infringe the anti-corruption law. This paper endeavors to find justifications to criminalizing corporate entiti(es) from a law and economics perspective. This paper argues that it is ultimately efficient for a party not to be held criminally liable for another party’s culpable act, and thus it concludes that individual vicarious criminal liability is inefficient. Unlike individual vicarious liability, corporate vicarious criminal liability might be efficient. This paper will also explain how and why the implementation of the corporate criminal liability should be classified differently with the liability of corporate officers, particularly under the regime anti-corruption law, so that the distinction between the personal acts of a high ranking corporate officers and the act of corruption involving the corporation itself can be unequivocally distinguished. This paper also critically evaluates Indonesia’s regulation and formulation of corporate entity criminal liability which pursuant to the anti-corruption law and to further examine whether Indonesia’s anti-corruption law has achieved its purpose.
Is the Theatre a Zombie? On the Successful Failures of Émile Zola
Authors: Rebellato Dan 
Published: April 2018

AbstractNaturalist theatre, in its late-nineteenth-century incarnation, and particularly in the work of Émile Zola, is often seen as advancing a physicalist view of the mind, where all mind states can be reduced to brain states. The novels and the plays do not uniformly or unambiguously support this analysis, so is the theory or the practice wrong? Physicalism is an idea that has had a recent renaissance, helped by the discoveries of neuroscience. Nevertheless I express some caution about the claims made for the eradication of free will. A range of thought experiments in the philosophy of mind have cast doubt on physicalism, culminating in David Chalmers’s much-debated zombie argument. I argue that zombies and their analogues represented deep social anxieties in the late nineteenth century, and make repeated appearances in Naturalism. The essay goes on to suggest that Naturalism should be considered to have conducted thought experiments, rather than just to have attempted to embody the theory on stage. Turning to John Searle’s ‘Chinese Room’ thought experiment, I suggest that theatre-making itself may be a kind of thought experiment model of the mind.
Actorship,parrhesia, and Representation: Remarks on Theatricality and Politics in Hobbes, Rousseau, and Diderot
Authors: Thomä Dieter 
Published: April 2018

AbstractThis paper addresses the strained relationship betweenparrhesiaand actorship and analyzes its political implications. These two terms seem to be antipodes:parrhesiaemphasizes thepresenceof a speaker or author whereas actorship deploysrepresentation. As their relation can be explained by means of the concept of representation it is worthwhile considering the two settings in which representation matters: theater and politics. These settings will be explored in case studies on Hobbes’s, Rousseau’s, and Diderot’s accounts ofparrhesiaand actorship. Hobbes dismissesparrhesiasticfreedom, minimalizes political authorship and favors a model of representation featuring a peculiar, powerful actor: the State. Rousseau criticizes actorship and representation, and seeks to re-install the people as sovereign author. This author is equipped with a strangely distorted form ofparrhesia. Diderot takes neither Hobbes’s nor Rousseau’s side. He hints at the political potential of the author-actor relationship and paves the way to a revised notion ofparrhesia.
Evaluation of some q-integrals in terms of the Dedekind eta function
Authors: Doyle Greg , Williams Kenneth S. 
Published: April 2018

Abstract
A q-integral is a definite integral of a function of q having an expansion in non-negative powers of q for

{|q|<1}

(q-series).
In his book on hypergeometric series, N. J. Fine [N. J. Fine,
Basic Hypergeometric Series and Applications,
Math. Surveys Monogr. 27,
American Mathematical Society, Providence, 1988] explicitly evaluated three q-integrals.
For example, he showed that

\int_{0}^{e^{-\pi}}\prod_{n=1}^{\infty}\frac{(1-q^{2n})^{20}}{(1-q^{n})^{16}}%
dq=\frac{1}{16}.

In this paper, we prove a general theorem which allows us to determine a wide class of integrals of this type. This class includes the three q-integrals evaluated by Fine as well as some of those evaluated by L.-C. Zhang [L.-C. Zhang,
Some q-integrals associated with modular forms,
J. Math Anal. Appl. 150 1990, 264–273]. It also includes many new evaluations of q-integrals.
Rabinowitz Alternative for Non-cooperative Elliptic Systems on Geodesic Balls
Authors: Rybicki Sławomir , Shioji Naoki , Stefaniak Piotr 
Published: April 2018

Abstract
The purpose of this paper is to study properties of continua (closed connected sets) of nontrivial solutions of non-cooperative elliptic systems considered on geodesic balls in

S
n

{S^{n}}

. In particular, we show that if the geodesic ball is a hemisphere, then all these continua are unbounded. It is also shown that the phenomenon of global symmetry-breaking bifurcation of such solutions occurs. Since the problem is variational and

SO
⁡

(
n
)

{\operatorname{SO}(n)}

-symmetric, we apply the techniques of equivariant bifurcation theory to prove the main results of this article. As the topological tool, we use the degree theory for

SO
⁡

(
n
)

{\operatorname{SO}(n)}

-invariant strongly indefinite functionals defined in [A. Gołȩbiewska and S. A. Rybicki, Global bifurcations of critical orbits of G-invariant strongly indefinite functionals, Nonlinear Anal. 74 2011, 5, 1823–1834].
Asymptotic behavior of the Timoshenko-type system with nonlinear boundary control
Authors: Ayadi Mohamed Ali , Bchatnia Ahmed 
Published: April 2018

AbstractIn this paper, we consider the Timoshenko-type system with nonlinear boundary dissipation. We prove the existence and uniqueness of the solution and we establish an explicit and general decay result for a wide class of the relaxation function, which depends on the length of the beam.
A Woven Web of Guesses: Xenophanes of Colophon
Authors: van Nispen Henri 
Published: April 2018

Abstract
Despite several attempts, amongst others from K.R. Popper, to re-evaluate the importance of Xenophanes of Colophon, this poet/philosopher is still frequently seen as a “somewhat precarious” figure in the history of philosophy. Xenophanes is mainly remembered for his bitter attacks on the anthropomorphic character of the Olympic gods, while his epistemology was discarded by Empedocles and Aristotle as being “too naïve”. This article tries to examine some of the reasons for this disqualification by analysing Popper’s attempt to rehabilitate Xenophanes as “the founder of the Greek enlightenment”.
Theodicy and Moral Responsibility in the Myth of Er
Authors: Ilievski Viktor 
Published: April 2018

Abstract
This paper focuses on Plato’s compressed theodicy in the Republic’s Myth of Er, which stems from the famous αἰτία ἑλομένου· θεὸς ἀναίτιος verdict, found at 617e4–5. Its direct implication is the understanding that the souls of the Myth are autonomous in making their choices, and therefore morally responsible for their decisions and actions. God is thus exonerated of all blame for the disappointments and sufferings they are going through, and his beneficent nature is defended, at least within the confines of the Myth’s rudimentary theodicy. It is my opinion that Plato is indeed justified in upholding such views. In order to demonstrate that, I shall try to argue that the claim of individual responsibility – upon which Plato’s theodicy in the Myth of Er is exclusively founded – withstands the charges of determinism and infinite regress of accountability, leveled against it by Annas, Halliwell, et al., and McPherran, Inwood, et al., respectively. I shall also try to make a case against Annas’ and Thayer’s allegations that the memory loss, which is one of the consequences of the reincarnation process, absolves the agent from culpability for the mistakes committed in his/her previous lives, because such loss implicates discontinuity of personal identity. Before engaging with this issues, however, I shall attempt to provide a possible Platonic account of the concept of freedom of choice – the basic precondition for moral responsibility – as employed in the Myth of Er.