bluuebunny/crossref_metadata_2025_split huggingface dataset:
18F-FDG PET/CT Quantitative Parameters and Texture Analysis Effectively Differentiate Endometrial Precancerous Lesion and Early-Stage Carcinoma
Authors: Wang Tong , Sun Hongzan , Guo Yan , Zou Lue 
Published: June 2019

Objective: This study evaluated the metabolic parameters and texture features of fluorodeoxyglucose positron emission tomography–computed tomography (PET/CT) for the diagnosis and differentiation of endometrial atypical hyperplasia (EAH), EAH with field cancerization (FC), and stage 1A endometrial carcinoma (EC 1a). Materials and Methods: We retrospectively analyzed the metabolic parameters of PET/CT in 170 patients with diagnoses confirmed by pathology, including 57 cases of EAH (57/170, 33.53%), 45 cases of FC (45/170, 26.47%), and 68 cases of EC 1a (68/170, 40.0%). Then, the texture features of each tumor were extracted and compared with the metabolic parameters and pathological results using nonparametric tests and linear regression analysis. The diagnostic performance was assessed by the area under the curve (AUC) values obtained from receiver operating characteristic analysis. Results: There were moderate positive correlations between the PET standardized uptake values (SUVpeak, SUVmax, and SUVmean) and postoperative pathological features with correlation coefficients ( r s) of 0.663, 0.651, and 0.651, respectively ( P < .001). Total lesion glycolysis showed relatively low correlation with pathological characteristics ( r s = 0.476), whereas metabolic tumor volume and age showed the weakest correlations ( r s = 0.186 and 0.232, respectively). To differentiate between the diagnosis of EAH and FC, SUVmax displayed the largest AUC of 0.857 (sensitivity, 82.2%; specificity, 84.2%). Five texture features were screened out as Percentile 40, Percentile 45, InverseDifferenceMoment_AllDirection_offset 1, InverseDifferenceMoment_angle 45_offset 4, and ClusterProminence_angle 135_offset 7 ( P < .001) by linear model of texture analysis (AUC = 0.851; specificity = 0.692; sensitivity = 0.871). To differentiate between the diagnoses of FC and EC 1a, SUVpeak displayed the largest AUC of 0.715 (sensitivity, 67.6%; specificity, 77.8%), and 2 texture features were identified as Percentile 10 and CP_angle 135_offset 7 (AUC = 0.819; specificity = 0.871; sensitivity = 0.766; P < .001). Conclusions: SUVmax and SUVpeak had the highest diagnostic values for EAH, FC, and EC 1a compared with the other tested parameters. SUVmax, Percentile 40, Percentile 45, InverseDifferenceMoment_AllDirection_offset 1, InverseDifferenceMoment_angle 45_offset 4, and ClusterProminence_angle 135_offset 7 distinguished EAH from FC. SUVpeak, Percentile 10, and ClusterProminence_angle 135_offset 7 distinguished FC from EC 1a. This study showed that the addition of texture features provides valuable information for differentiating EAH, FC, and EC 1a diagnoses.
Developing Evidence-Based Design Guidelines for Medical/Surgical Hospital Patient Rooms That Meet the Needs of Staff, Patients, and Visitors
Authors: Lavender Steven A. , Sommerich Carolyn M. , Sanders Elizabeth B.-N. , Evans Kevin D. , Li Jing , Radin Umar Radin Zaid , Patterson Emily S. 
Published: June 2019

Objectives: This research investigated medical/surgical (Med/Surg) patient room design to accommodate the needs of hospital staff, while at the same time accommodating the needs of patients and their visitors. Background: Designing hospital patient rooms that provide a comfortable healing experience for patients, while at the same time meeting the needs of the hospital staff, is a challenging process. Prior research has shown that many hospital patient room designs adversely affect the ability of hospital staff to perform their tasks effectively, efficiently, and safely. Method: Twenty-seven design sessions were conducted in which 104 participants, representing 24 different occupations, worked in small mixed occupational groups to design an ideal single patient Med/Surg patient room to fit their collective needs using a full-scale mock-up. During analysis, the investigators reduced the resulting 27 room designs to 5 hybrid designs that were sequentially reviewed by patients and visitors and by staff to address design conflicts. Results: This design process identified 51 desirable room design features that were incorporated into 66 evidence-based design guidelines for the different areas within the Med/Surg patient room including the entry way (16 guidelines), the patient clinical area (22 guidelines), the bathroom (17 guidelines), the family area (8 guidelines), and storage areas for patients and their visitors (3 guidelines). Conclusions: The guidelines developed through this study identified many opportunities for improving the design of hospital Med/Surg rooms to allow staff to be more effective, efficient, and safer, while at the same time addressing the design needs of patients and their visitors.
Characteristics of Adults With Type 2 Diabetes Mellitus by Category of Chronic Kidney Disease and Presence of Cardiovascular Disease in Alberta Canada: A Cross-Sectional Study
Authors: Tonelli Marcello , Wiebe Natasha , Richard Jean-Francois , Klarenbach Scott W. , Hemmelgarn Brenda R. 
Published: June 2019

Background: Type 2 diabetes mellitus (T2DM) is associated with an excess risk of cardiovascular disease (CVD) and chronic kidney disease (CKD). Although CVD, CKD, and use of antihyperglycemic treatments are all key drivers of the costs and consequences experienced by people with diabetes, no recent Canadian data describe these characteristics among adults with diabetes. Objective: To describe prevalence of CVD, CKD, and use of antihyperglycemic treatments among adults with diabetes. Design: Retrospective population-based, cross-sectional study. Setting: Alberta, Canada. Patients: All adults with T2DM as of March 31, 2017. Measurements: We described the demographic and clinical characteristics by CKD stage and CVD status and type. CKD stage was categorized according to international guidelines and based on estimated glomerular filtration rate (eGFR) and severity of albuminuria. Methods: Clinical and demographic characteristics were defined using provincial administrative data; medication use was based on data from the provincial drug plan. Additional analyses examined subgroups based on demographic characteristics, clinical characteristics, and medication use. Results: There were 260 903 participants, all of whom had T2DM. Median age was 64 years; 53.6% were male; and 10.9% lived in rural communities. Median duration of diabetes was 7.7 years. Half of the participants had A1C <7%. Overall, 33.0% had CKD; among these most had eGFR <60 mL/min/1.73 m2; 11.1%, 5.6%, and 2.9% had CKD stages 3a, 3b, and 4/5, respectively. The overall prevalence of CVD (prior myocardial infarction, stroke/transient ischemic attack, or peripheral artery disease) was 22.5%; prevalence increased in parallel with the presence of CKD: 14.4%, 28.8%, 35.7%, 44.3%, and 50.9% for stages 1, 2, 3a, 3b, and 4/5, respectively. Prescriptions for antihyperglycemic medications were more common in people with CKD as compared with those without. However, the use of all antihyperglycemic medications except insulin and meglitinide was progressively lower in the presence of more severe CKD. Limitations: The study is based on administrative data; therefore, the findings could be influenced by measurement error (eg, accuracy of diagnostic and procedural codes and prescription drug codes used). Conclusions: These findings will be useful to policy makers seeking to understand the burden of diabetes-related kidney disease as well as the potential budget implications and potential clinical benefits of expanded use of antihyperglycemic use in this population.
CyBorD-DARA is potent initial induction for MM and enhances ADCP: initial results of the 16-BCNI-001/CTRIAL-IE 16-02 study
Authors: O’Dwyer M. , Henderson R. , Naicker S. D. , Cahill M. R. , Murphy P. , Mykytiv V. , Quinn J. , McEllistrim C. , Krawczyk J. , Walsh J. , Lenihan E. , Kenny T. , Hernando A. , Hirakata G. , Parker I. , Kinsella E. , Gannon G. , Natoni A. , Lynch K. , Ryan A. E. 
Published: June 2019

Abstract
Daratumumab (DARA) has shown impressive activity in combination with other agents for the treatment of multiple myeloma (MM). We conducted a phase 1b study to assess the safety and preliminary efficacy, as well as potential mechanisms of action, of DARA (16 mg/kg) in combination with a weekly schedule of subcutaneous bortezomib (1.3-1.5 mg/m2), cyclophosphamide (150-300 mg/m2), and dexamethasone (40 mg) (CyBorD DARA) as initial induction before autologous stem cell transplantation (ASCT). Eligible patients were ≤70 years of age with untreated MM requiring treatment and who lacked significant comorbidities. A total of 18 patients were enrolled. Their median age was 56 years (range, 32-66 years), and all patients had Eastern Cooperative Oncology Group performance status ≤1. The International Staging System stages were I, II, and III in 78%, 17%, and 6% of patients, respectively; 28% of patients had high-risk genetic features. There was no dose-limiting toxicity, and the incidence of grade 3 or 4 infection or neutropenia was &lt;10%. On an intention-to-treat basis, 94% achieved ≥very good partial response with ≥complete response in 44% of patients. Among 14 of 15 patients who underwent ASCT and were evaluable for response, all 14 achieved at least very good partial response, with 8 (57%) of 14 achieving complete response. After ASCT, 10 (83%) of 12 patients in whom minimal residual disease analysis was possible were negative at a sensitivity of 10−5 (56% on intention-to-treat/whole study population) according to next-generation sequencing. Flow cytometry analysis of patient samples indicated CyBorD DARA induced activation of macrophage-mediated antibody-dependent cellular phagocytosis. This trial was registered at www.clinicaltrials.gov as #NCT02955810.
Predictors of lower extremity amputation in patients with diabetic foot ulcer: findings from MEDFUN, a multi‐center observational study
Authors: Ugwu Ejiofor , Adeleye Olufunmilayo , Gezawa Ibrahim , Okpe Innocent , Enamino Marcelina , Ezeani Ignatius 
Published: June 2019

AbstractBackgroundLower extremity amputation (LEA) is a potential sequelae of diabetic foot ulceration (DFU) and is associated with huge morbidly and mortality. Low and middle income countries are currently at the greatest risk of diabetes‐related complications and deaths. We sought to identify demographic, clinical and laboratory variables that significantly predict LEA in patients hospitalized for DFU.MethodsThe Multi‐center Evaluation of Diabetic Foot Ulcer in Nigeria (MEDFUN) was an observational study conducted between March 2016 and April 2017 in six tertiary healthcare institutions. We prospectively followed 336 diabetic patients hospitalized for DFU and managed by a multidisciplinary team until discharge or death. Demographic and diabetes‐related information and ulcer characteristics were documented. Patients were evaluated for neuropathy, peripheral arterial disease (PAD) and medical co‐morbidities while relevant laboratory and imaging tests were performed. The study end‐points were ulcer healing, LEA, duration of hospitalization and mortality. Here we present data on amputation.ResultsOne hundred and nineteen subjects (35.4%) underwent LEA during the follow‐up period. Univariate predictors of LEA were ulcer duration more than 1 month prior to hospitalization (P <  0.001), PAD (P <  0.001), Wagner grade ≥ 4 (P <  0.001), wound infection (P 0.041), Proteinuria (P 0.021), leucocytosis (P 0.001) and osteomyelitis (P <  0.001). On multivariate regression, only three variables emerged as significant independent predictors of LEA and these include: ulcer duration more than 1 month (O.R. 10.3, 95% C.I. 4.055–26.132), PAD (O.R. 2.8, 95% C.I. 1.520–5.110) and presence of osteomyelitis (O.R. 5.6, 95% C.I. 2.930–10.776). Age, gender, diabetes type and duration, neuropathy, glycemic control and anemia did not predict LEA in the studied population.ConclusionWe identified duration of ulcer greater than 1 month, PAD, Wagner grade 4 or higher, proteinuria, leucocytosis, wound infection and osteomyelitis as the significant predictors of LEA in patients hospitalized for DFU. Prompt attention to these risk factors may reduce amputation rate among these patients.
Crisis-planning interventions for people with psychotic illness or bipolar disorder: systematic review and meta-analyses
Authors: Molyneaux Emma , Turner Amelia , Candy Bridget , Landau Sabine , Johnson Sonia , Lloyd-Evans Brynmor 
Published: June 2019

Background
Mental health services lack a strong evidence base on the most effective interventions to reduce compulsory admissions. However, some research suggests a positive impact of crisis-planning interventions in which patients are involved in planning for their future care during a mental health crisis.

Aims
This review aimed to synthesise randomised controlled trial (RCT) evidence on the effectiveness of crisis-planning interventions (for example advance statements and joint crisis plans) in reducing rates of compulsory hospital admissions for people with psychotic illness or bipolar disorder, compared with usual care (PROSPERO registration number: CRD42018084808).

Method
Six online databases were searched in October 2018. The primary outcome was compulsory psychiatric admissions and secondary outcomes included other psychiatric admissions, therapeutic alliance, perceived coercion and cost-effectiveness. Bias was assessed using the Cochrane collaboration tool.

Results
The search identified 1428 studies and 5 RCTs were eligible. One study had high risk of bias because of incomplete primary outcome data. Random-effects meta-analysis showed a 25% reduction in compulsory admissions for those receiving crisis-planning interventions compared with usual care (risk ratio 0.75, 95% CI 0.61–0.93, P = 0.008; from five studies). There was no statistical evidence that the intervention reduced the risk of voluntary or combined voluntary and compulsory psychiatric admissions. Few studies assessed other secondary outcomes.

Conclusions
Our meta-analysis suggests that crisis-planning interventions substantially reduce the risk of compulsory admissions among individuals with psychotic illness or bipolar disorder. Despite common components, interventions varied in their content and intensity across the trials. The optimal models and implementation of these interventions require further investigation.

Declaration of interest
E.M., S.L., S.J. and B.L.-E. received funding from the National Institute for Health Research during the conduct of the study.
An Accurate Substitution Method To Minimize Left Censoring Bias in Serum Steroid Measurements
Authors: Handelsman David J , Ly Lam P 
Published: June 2019

AbstractHormone assay results below the assay detection limit (DL) can introduce bias into quantitative analysis. Although complex maximum likelihood estimation methods exist, they are not widely used, whereas simple substitution methods are often used ad hoc to replace the undetectable (UD) results with numeric values to facilitate data analysis with the full data set. However, the bias of substitution methods for steroid measurements is not reported. Using a large data set (n = 2896) of serum testosterone (T), DHT, estradiol (E2) concentrations from healthy men, we created modified data sets with increasing proportions of UD samples (≤40%) to which we applied five different substitution methods (deleting UD samples as missing and substituting UD sample with DL, DL/√2, DL/2, or 0) to calculate univariate descriptive statistics (mean, SD) or bivariate correlations. For all three steroids and for univariate as well as bivariate statistics, bias increased progressively with increasing proportion of UD samples. Bias was worst when UD samples were deleted or substituted with 0 and least when UD samples were substituted with DL/√2, whereas the other methods (DL or DL/2) displayed intermediate bias. Similar findings were replicated in randomly drawn small subsets of 25, 50, and 100. Hence, we propose that in steroid hormone data with ≤40% UD samples, substituting UD with DL/√2 is a simple, versatile, and reasonably accurate method to minimize left censoring bias, allowing for data analysis with the full data set.
Dust and Roses
Authors: Mieszkowski Jan 
Published: June 2019

AbstractTracing a trajectory of literary and philosophical texts from the ancient atomists to the late twentieth century, this essay explores the surprisingly consistent role that dust has played in the conceptualization of language. In Lucretius, Sophocles, and the New Testament, dust is as much a standard of representation as it is one object of representation among others. In the most extreme case, it becomes the defining medium of inscription. In Paul Celan’s work, the attempt to articulate a rhetoric of negation that will put language on something other than a dusty footing comes perilously close to demonstrating that all verse unfolds under the aegis of the word dust. The essay closes by suggesting that Jorie Graham’s poetry offers a new perspective on what it would mean to read the surface of a text, particularly when that text is dusty.
Queer Procreation
Authors: Pahl Katrin 
Published: June 2019

AbstractAt the intersection of two fields of inquiry that are highly imaginative and seek real change—the study of human-plant relations and the even less charted study of queer procreation—this article explores queer ways of procreating that humans may learn from plants. In particular, stolon (runner) formation and grafting are considered here because they are vegetal forms of procreation that are not rooted in sexual difference and create collective life forms that are based on dividuality rather than individuality. Both characteristics are mobilized for a queer imagination. Analyzing two plays by Heinrich von Kleist—the comedy Amphitryon (1807) and the tragedy Penthesilea (1808)—the article argues that Amphitryon’s servant, Sosias, multiplies by way of stolons and that the Amazons in Penthesilea are grafted creatures with an ongoing desire to form new grafts. The analysis draws on Gilles Deleuze’s theory of masochism to shift attention away from genital intercourse while sexualizing what in biology is called asexual.
Tau interacts with SHP2 in neuronal systems and in Alzheimer's disease brains
Authors: Kim Yohan , Liu Guanghao , Leugers Chad J. , Mueller Joseph D. , Francis Meghan B. , Hefti Marco M. , Schneider Julie A. , Lee Gloria 
Published: June 2019

ABSTRACT
Microtubule-associated protein tau, an integral component of neurofibrillary tangles, interacts with a variety of signaling molecules. Previously, our laboratory reported that nerve growth factor (NGF)-induced MAPK activation in a PC12-derived cell line was potentiated by tau, with phosphorylation at T231 being required. Therefore, we sought to identify a signaling molecule involved in the NGF-induced Ras-MAPK pathway that interacted with phospho-T231-tau. Here, we report that the protein tyrosine phosphatase SHP2 (also known as PTPN11) interacted with tau, with phospho-T231 significantly enhancing the interaction. By using proximity ligation assays, we found that endogenous tau–SHP2 complexes were present in neuronal cells, where the number of tau–SHP2 complexes significantly increased when the cells were treated with NGF, with phosphorylation at T231 being required for the increase. The interaction did not require microtubule association, and an association between tau and activated SHP2 was also found. Tau–SHP2 complexes were also found in both primary mouse hippocampal cultures and adult mouse brain. Finally, SHP2 levels were upregulated in samples from patients with mild and severe Alzheimer's disease (AD), and the level of tau–SHP2 complexes were increased in AD patient samples. These findings strongly suggest a role for the tau–SHP2 interaction in NGF-stimulated neuronal development and in AD.
This article has an associated First Person interview with the first author of the paper.
Biological analysis of flexor tendon repair-failure stump tissue: a potential recycling of tissue for tendon regeneration
Authors: Lu C-C. , Zhang T. , Reisdorf R. L. , Amadio P. C. , An K-N. , Moran S. L. , Gingery A. , Zhao C. 
Published: June 2019

Objectives Re-rupture is common after primary flexor tendon repair. Characterization of the biological changes in the ruptured tendon stumps would be helpful, not only to understand the biological responses to the failed tendon repair, but also to investigate if the tendon stumps could be used as a recycling biomaterial for tendon regeneration in the secondary grafting surgery. Methods A canine flexor tendon repair and failure model was used. Following six weeks of repair failure, the tendon stumps were analyzed and characterized as isolated tendon-derived stem cells (TDSCs). Results Failed-repair stump tissue showed cellular accumulation of crumpled and disoriented collagen fibres. Compared with normal tendon, stump tissue had significantly higher gene expression of collagens I and III, matrix metalloproteinases (MMPs), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and insulin-like growth factor (IGF). The stump TDSCs presented both mesenchymal stem and haematopoietic cell markers with significantly increased expression of CD34, CD44, and CD90 markers. Stump TDSCs exhibited similar migration but a lower proliferation rate, as well as similar osteogenic differentiation but a lower chondrogenic/adipogenic differentiation capability, compared with normal TDSCs. Stump TDSCs also showed increasing levels of SRY-box 2 (Sox2), octamer-binding transcription factor 4 (Oct4), tenomodulin (TNMD), and scleraxis (Scx) protein and gene expression. Conclusion We found that a failed repair stump had increased cellularity that preserved both mesenchymal and haematopoietic stem cell characteristics, with higher collagen synthesis, MMP, and growth factor gene expression. This study provides evidence that tendon stump tissue has regenerative potential. Cite this article: C-C. Lu, T. Zhang, R. L. Reisdorf, P. C. Amadio, K-N. An, S. L. Moran, A. Gingery, C. Zhao. Biological analysis of flexor tendon repair-failure stump tissue: A potential recycling of tissue for tendon regeneration. Bone Joint Res 2019;8:232–245. DOI: 10.1302/2046-3758.86.BJR-2018-0239.R1.
Short Communication: Herpetofauna diversity, potential ecotourism in Mount Galunggung, West Java, Indonesia
Authors: RIYANTO AWAL , SULAEMAN TAUFAN NURZAMAN , RACHMAN NUR , CHAIDIR DIKI MUHAMAD , TRILAKSONO WAHYU , FARAJALLAH ACHMAD 
Published: June 2019

Abstract. Riyanto A, Sulaeman TN, Rachman N, Chaidir DM, Trilaksono W, Farajallah A. 2019. Short Communication: Herpetofauna diversity, potential ecotourism in Mount Galunggung, West Java, Indonesia. Biodiversitas 20: 1173-1179. Here we provide a list of herpetofauna at Mount Galunggung, West Java, Indonesia as potential biodiversity for ecotourism. Data were collected from our observations in March 2013 and November 2018 using visual and acoustic encounter search methods in the three zones (hot springs, craters, and foothills) on the nature tourism destination of the mount. We revealed 35 species of herpetofauna and their local distribution on these zones. Even though the diversity of herpetofauna has not been observed completely, we suggested that the biodiversity data from this zone should be used as the basic capital in turning nature tourism base into ecotourism base, so that it would provide more benefits to biodiversity conservation itself and to the local community.