bluuebunny/crossref_metadata_2025_split huggingface dataset:
NOVA GAZETA RENANA: A POLÍTICA EM SUA DIMENSÃO NEGATIVA NO PENSAMENTO DE MARX
Authors: Nobre Lopes Fátima Maria , Silva Filho Adauto Lopes da 
Published: January 2019

Este texto em si não discorre sobre a concepção da política em Marx. Trata-se apenas de uma sumária exposição dos seus artigos A Burguesia e a Contra Revolução, datados de 10 a 31 de dezembro de 1848, que fizeram parte dos seus escritos no jornal Nova Gazeta Renana. Dada à riqueza de conteúdos dos supracitados artigos, dentre eles selecionamos a concepção negativa da política, tentando resgatar os lineamentos que identificam tal concepção. Desta forma, dividimos esta exposição em três partes: a primeira parte introduz a posição política de Marx no referido jornal; a segunda parte trata dos artigos propriamente ditos, na qual procuramos apresentá-los citando trechos principais que indicam o assunto tratado cujo fundamento se encontra nas considerações da terceira parte com destaque à crítica de Marx ao pensamento político de Hegel.
Antimicrobial susceptibility and virulence genes of clinical and environmental isolates ofPseudomonas aeruginosa
Authors: Liew Siew Mun , Rajasekaram Ganeswrei , Puthucheary SD Ampalam , Chua Kek Heng 
Published: January 2019

BackgroundPseudomonas aeruginosais ubiquitous, has intrinsic antibiotic resistance mechanisms, and is associated with serious hospital-associated infections. It has evolved from being a burn wound infection into a major nosocomial threat. In this study, we compared and correlated the antimicrobial resistance, virulence traits and clonal relatedness between clinical and fresh water environmental isolates ofP. aeruginosa.Methods219P. aeruginosaisolates were studied: (a) 105 clinical isolates from 1977 to 1985 (n = 52) and 2015 (n = 53), and (b) 114 environmental isolates from different fresh water sources. All isolates were subjected to ERIC-PCR typing, antimicrobial susceptibility testing and virulence factor genes screening.ResultsClinical and environmental isolates ofP. aeruginosawere genetically heterogenous, with only four clinical isolates showing 100% identical ERIC-PCR patterns to seven environmental isolates. Most of the clinical and environmental isolates were sensitive to almost all of the antipseudomonal drugs, except for ticarcillin/clavulanic acid. Increased resistant isolates was seen in 2015 compared to that of the archived isolates; four MDR strains were detected and all were retrieved in 2015. All clinical isolates retrieved from 1977 to 1985 were susceptible to ceftazidime and ciprofloxacin; but in comparison, the clinical isolates recovered in 2015 exhibited 9.4% resistance to ceftazidime and 5.7% to ciprofloxacin; a rise in resistance to imipenem (3.8% to 7.5%), piperacillin (9.6% to 11.3%) and amikacin (1.9% to 5.7%) and a slight drop in resistance rates to piperacillin/tazobactam (7.7% to 7.5%), ticarcillin/clavulanic acid (19.2% to 18.9%), meropenem (15.4% to 7.5%), doripenem (11.5% to 7.5%), gentamicin (7.7% to 7.5%) and netilmicin (7.7% to 7.5%). Environmental isolates were resistant to piperacillin/tazobactam (1.8%), ciprofloxacin (1.8%), piperacillin (4.4%) and carbapenems (doripenem 11.4%, meropenem 8.8% and imipenem 2.6%). Both clinical and environmental isolates showed high prevalence of virulence factor genes, but none were detected in 10 (9.5%) clinical and 18 (15.8%) environmental isolates. TheexoTgene was not detected in any of the clinical isolates. Resistance to carbapenems (meropenem, doripenem and imipenem), β-lactamase inhibitors (ticarcillin/clavulanic acid and piperacillin/tazobactam), piperacillin, ceftazidime and ciprofloxacin was observed in some of the isolates without virulence factor genes. Five virulence-negative isolates were susceptible to all of the antimicrobials. Only one MDR strain harbored none of the virulence factor genes.ConclusionOver a period of 30 years, a rise in antipseudomonal drug resistance particularly to ceftazidime and ciprofloxacin was observed in two hospitals in Malaysia. The occurrence of resistant environmental isolates from densely populated areas is relevant and gives rise to collective anxiety to the community at large.
Qualification of the Childcare Approach: an Intervention in the Family Health Strategy / Service Qualificação do Cuidado a Puericultura: uma Intervenção em Serviço na Estratégia de Saúde da Família
Authors: Brígido Abel Fernández , SANTOS ELITIELE ORTIZ DOS , Do Prado Ernande Valentin 
Published: January 2019

Objetivo: O estudo apresenta o relato de experiência de uma intervenção que teve como objetivo qualificar a puericultura em uma Estratégia de Saúde da Família no município de Boa Vista/Roraima. Método: A intervenção envolveu toda a equipe e teve a duração de 16 semanas, entre março a julho de 2015, nos quais foram instituídas ações direcionadas à organização e gestão do serviço, ao monitoramento e avaliação, à qualificação da prática clínica e ao engajamento público. Resultados: As ações permitiram qualificar o cuidado a 411 crianças, obtendo-se 98,6% da cobertura de atendimento, assim como a qualificação da prática clínica, adesão as ações com 100% de monitoramento do estado nutricional e desenvolvimento psicomotor, além da ampliação das atividades de promoção da saúde. Conclusão: A experiência contribuiu para melhorar a organização do serviço e integração da equipe alcançando resultados efetivos de cobertura e de qualidade da atenção relacionados a assistência a criança.
Cobalt‐Catalyzed 2‐(1‐Methylhydrazinyl)pyridine‐Assisted Direct C−H/N−H Functionalization of Benzoyl Hydrazide with Isocyanide: Efficient Synthesis of Iminoisoindolinone Derivatives
Authors: Zhao Hua , Shao Xiaoru , Qing Zhineng , Wang Taimin , Chen Xiaoming , Yang Hongjian , Zhai Hongbin 
Published: January 2019

AbstractA cobalt‐catalyzed direct C−H/N−H functionalization of benzoyl hydrazide with isocyanide by utilizing 2‐(1‐methylhydrazinyl)pyridine (MHP) as a bidentate directing group has been developed. This formal [4+1] cycloaddition protocol showed high efficiency and remarkable functional group tolerance, and the ubiquitous 3‐iminoisoindolinones were obtained in good to excellent yields in the presence of the earth‐abundant cobalt catalyst. Moreover, this transformation was accomplished by employing environmentally friendly oxygen as the sole oxidant in the absence of any other additives.magnified image
Lichtgetriebene Ein‐Elektronen‐Transferprozesse als Funktionsprinzip in der Schwefel‐ und Selen‐Multikatalyse
Authors: Breder Alexander , Depken Christian 
Published: January 2019

AbstractDas Prinzip der Kooperativität stellt inzwischen einen Grundpfeiler im Bereich der Multikatalyse dar. Durch die Kombination zweier oder mehrerer Katalysatoren mit mechanistisch unterschiedlichen Aktivierungsmodi, die gemeinsam chemische Prozesse vorantreiben, werden zuweilen Bindungsknüpfungen ermöglicht, zu denen keiner der beteiligten Katalysatoren einzeln imstande wäre. Ein stetig wachsender Teilbereich der Multikatalyse befasst sich mit lichtgetriebenen Ein‐Elektronen‐Transferprozessen, die durch die synergistische Verzahnung von Schwefel‐ oder Selenkatalysatoren mit Photoredoxkatalysatoren aufrechterhalten werden. Reaktionen, die auf diesem Funktionsprinzip beruhen, bergen ein enormes synthetisches Potential, da sie rasche und hoch ökonomische Zugangswege zu komplexen molekularen Strukturen ermöglichen können. Vor diesem Hintergrund ist das Ziel dieses Aufsatzes, jüngste methodische Entwicklungen auf diesem Gebiet näher zu beleuchten und anhand ausgewählter Beispielreaktionen einen allgemeinen Einblick in ihre mechanistischen Grundlagen zu vermitteln.
Role of Flaxseed Meal Feeding for Different Durations in the Lipid Deposition and Meat Quality in Broiler Chickens
Authors: Kumar Faneshwar , Tyagi Praveen K. , Mir Nasir Akbar , Tyagi Pramod K. , Dev Kapil , Bera Indrajit , Biswas Ashim K. , Sharma Divya , Mandal Asit Baran , Deo Chandra 
Published: January 2019

AbstractThis study investigated the role of flaxseed meal (FSM), a rich terrestrial source of ω‐3 fatty acids, in the alteration of the fatty acid profile and metabolism, health indices, physicochemical properties, and sensory quality of broiler chicken meat. The broiler chickens were fed 100 g FSM kg−1 diet for different time periods (1, 2, 3, 4, and 5 weeks). The results revealed that 100 g FSM feeding in broiler chickens for at least 3 weeks increased (P < 0.01) the EPA, DHA, MUFA, PUFA, ω‐3 PUFA, and ω‐6 PUFA of broiler chicken meat with the corresponding decrease in palmitic acid, stearic acid, and SFA content. 100 g FSM feeding up to 3 weeks has increased the Δ9‐desaturases (P < 0.05), thioesterase index (P < 0.01), and Δ5‐desaturase + Δ6‐desaturase activity (P < 0.01) along with an improvement in health indices (P < 0.01) of chicken meat. Similarly, a reduction in meat cholesterol and fat content of thigh meat (P < 0.01) was observed by feeding 100 g FSM for at least 3 weeks with no effect on the pH, color scores, and sensory evaluation of broiler chicken meat. The water‐holding capacity (WHC) and extract release volume (ERV) decreased, whereas, drip loss of meat increased (P < 0.01) due to the feeding of 100 g FSM beyond 3 weeks. Thus, this study concluded that 100 g FSM feeding for 3 weeks in broiler chickens significantly improves the fatty acid profile, lipid metabolism, and health indices of meat, without compromising the physicochemical properties of broiler chicken meat.
Covalorization of Palm Oil‐Refining by‐Products as Soaps
Authors: Punvichai Teerasak , Pioch Daniel 
Published: January 2019

AbstractThis study deals with the covalorization of spent bleaching clay (SBC) and palm fatty acid distillate (PFAD), the by‐products of palm oil‐refining plants (3 Mt. year−1), through soap manufacture. Obtained SBC and PFAD samples show differing acidity and saponification values depending on their content of free fatty acids and of acylglycerols. The SBC sample had an acidity of 60.5% and a saponification value of 182 mg KOH g−1 of oil, and the PFAD sample has an acidity of 88.4% and a saponification value of 204 mg KOH g−1 of oil. Soaps are prepared using the stoichiometric amount of NaOH, under varying proportion of water introduced through the basic solution. The overall reaction (neutralization and saponification) is complete (99.9%) with PFAD, whereas the yield reaches only 56.1% with SBC. When mixing SBC and PFAD, for example under a 1:1 weight ratio, the overall reaction completion (87.7%) is surprisingly higher than expected based on the computed individual reaction yields (78%), showing a synergistic effect of about 10% on the course of the saponification reaction of acylglycerols in SBC. The water content was found to be a critical parameter, 30% w/w of added water providing the highest yield. These results show an innovative way for covalorizing two important by‐products of palm oil industrial processing as a single final product. By‐products of the physical refining of other oils could also be valorized following the same method.
Cu3MS4 (M=V, Nb, Ta) and its Solid Solutions with Sulvanite Structure for Photocatalytic and Photoelectrochemical H2 Evolution under Visible‐Light Irradiation
Authors: Ikeda Satoru , Aono Naruhiko , Iwase Akihide , Kobayashi Hisayoshi , Kudo Akihiko 
Published: January 2019

AbstractSolid solutions with of Cu3VS4 with either Cu3NbS4 or Cu3TaS4 (Cu3Nb1−xVxS4 or Cu3Ta1−xVxS4) were prepared by a solid‐state reaction and adopted a sulvanite structure. Their band gaps were 1.6–1.7 eV corresponding to the absorption of a wide range of visible light. Ru cocatalyst‐loaded Cu3MS4 (M=V, Nb, Ta), Cu3Nb1−xVxS4, and Cu3Ta1−xVxS4 showed photocatalytic activities for sacrificial H2 evolution under visible‐light irradiation. Most solid solutions showed better activities than the single‐component Cu3MS4 (M=V, Nb, Ta). Cu3MS4 (M=V, Nb), Cu3Nb1−xVxS4, and Cu3Ta1−xVxS4 also functioned as photoelectrodes and gave cathodic photocurrents under visible‐light irradiation, indicating a p‐type semiconductor character. Cu3Nb0.9V0.1S4 showed the best photocatalytic and photoelectrochemical performances. When Ru‐loaded Cu3Nb0.9V0.1S4 was used as a photocathode with a CoOx‐loaded BiVO4 photoanode, photoelectrochemical water splitting proceeded under simulated sunlight irradiation without an external bias.
Intermingling of chromosome territories
Authors: Szczepińska Teresa , Rusek Anna Maria , Plewczynski Dariusz 
Published: January 2019

AbstractThe importance of higher order nuclear structure and compartmentalization for the control of the cell life is now indisputable. The genome of higher eukaryotes is organized into definite chromosome territories, and the three‐dimensional organization of these territories may be intently related to genomic function, global regulation of gene expression, and even formation of exchange aberrations. In this review, we discuss our current understanding of the chromosome territories phenomenon and briefly describe how genes relocation in three‐dimensional arrangement of the genome may influence their functioning. We explain how the intermingling of the edges of chromosome territories allows the formation of rare long‐range interchromosomal interactions. Moreover, we illustrate recent discoveries describing the mechanisms of physical proximity‐based chromosome translocations and its clinical consequence for fusion genes formation and tumor development. Finally, we characterize the inner structure of the intermingled chromosomes briefly, and explain how chromosome intermingling affects gene expression regulation.
Correlations between serum amyloid A, C‐reactive protein and clinical indices of patients with acutely exacerbated chronic obstructive pulmonary disease
Authors: Lin Tian‐Lai , Chen Wei‐Wen , Ding Zhi‐Rong , Wei Si‐Can , Huang Ming‐Lian , Li Cai‐Hui 
Published: January 2019

BackgroundTo explore the correlations between SAA, CRP, and clinical indices of patients with acutely exacerbated chronic obstructive pulmonary disease (AECOPD).MethodsA total of 120 patients with AECOPD and another 120 with remitted COPD were enrolled in an AECOPD group and a COPD remission group, respectively. Meanwhile, 120 healthy subjects were included as a control group. SAA, CRP, PCT, Fbg, IL‐8, IL‐6, TNF‐α, and IP‐10 levels were detected. FEV1 and FEV1/FVC were measured.ResultsCompared with control group, the serum levels of SAA, CRP, PCT, Fbg, IL‐8, IL‐6, TNF‐α, and IP‐10 significantly increased in COPD remission group (P < 0.05). The levels of AECOPD group significantly exceeded those of COPD remission group (P < 0.05). The levels of AECOPD patients with different GOLD grades were significantly different (P < 0.05). AECOPD group had significantly lower FEV1 and FEV1/FVC than those of COPD remission group (P < 0.05). The CAT score of AECOPD patients was (18.41 ± 2.55) points. The levels of SAA, CRP, PCT, Fbg, IL‐8, IL‐6, TNF‐α, and IP‐10 were negatively correlated with FEV1 and FEV1/FVC, and positively correlated with CAT score. The area under receiver operating characteristic curve of SAA was largest (0.931). The cutoff values for SAA, CRP, PCT and Fbg were 18.68 mg/L, 14.70 mg/L, 0.39 μg/L, 3.91 g/L, 0.46 μg/L, 24.17 μg/L, 7.18 mg/L, and 83.19 ng/L, respectively.ConclusionsSerum levels of SAA, CRP, PCT, Fbg, IL‐8, IL‐6, TNF‐α, and IP‐10 in AECOPD patients were elevated, which may undermine pulmonary functions. SAA can be used as an effective index for AECOPD diagnosis and treatment.
Positive correlation between vitamin D receptor gene TaqI variant and gastric cancer predisposition in a sample of Iranian population
Authors: Parsamanesh Negin , Moossavi Maryam , Tavakkoli Tahmineh , Javdani Hossein , Fakharian Tahereh , Moossavi Seyedeh Zahra , Naseri Mohsen 
Published: January 2019

AbstractGastric cancer is the second cause of cancer‐related mortality and the fourth most common cancers worldwide. Owing to the immune modulatory effect of vitamin D in the body, the role of vitamin D receptor gene in vitamin D regulation receives a great deal of research interest. The aim of the current study was to highlight the association between two variants of TaqI and FokI in the vitamin D receptor gene and gastric cancer predisposition in a sample of South Khorasan population. The present investigation consisted of 69 patients affected with gastric cancer and 100 healthy individuals. The genomic DNA was extracted by salting out the protocol from peripheral venous blood. Genotyping of TaqI and FokI variants were performed by PCR‐RFLP method. Our findings manifested that TC genotype of TaqI polymorphism was statistically significant between the case and the control groups (p = 0.002). Moreover, the frequency of TC + CC genotypes was statistically significant between the two groups (p = 0.009). Furthermore, we could not find any meaningful association between FokI variant and the participant groups. The present results declared that, in our population, TC genotype of TaqI polymorphism has an association with gastric cancer susceptibility. In addition, more investigation with greater sample sizes is needed to confirm our results.
Association between body composition, survival, and toxicity in advanced esophagogastric cancer patients receiving palliative chemotherapy
Authors: Dijksterhuis Willemieke P.M. , Pruijt Maarten J. , van der Woude Stephanie O. , Klaassen Remy , Kurk Sophie A. , van Oijen Martijn G.H. , van Laarhoven Hanneke W.M. 
Published: January 2019

AbstractBackgroundPalliative systemic treatment in patients with advanced or metastatic esophagogastric cancer may result in improved overall survival and quality of life but can also lead to considerable toxicity. In various cancer types, severe muscle mass depletion (sarcopenia) and poor muscle strength are associated with decreased survival and increased chemotherapy‐related toxicity. The aim of this study is to determine the impact of body composition on survival and chemotherapy toxicity in esophagogastric cancer patients treated with first‐line palliative chemotherapy.MethodsA total of 88 patients with advanced esophagogastric cancer treated with standard first‐line palliative systemic therapy consisting of capecitabine and oxaliplatin (CapOx) between January 2010 and February 2017 were included. Skeletal muscle index (SMI), reflecting muscle mass, and skeletal muscle density (SMD), associated with muscle strength, were measured using pre‐treatment of all patients and evaluation computed tomography scans after three treatment cycles of 65 patients and were used to determine sarcopenia and sarcopenic obesity (i.e. sarcopenia and body mass index >25 kg/m2). The associations between body composition (SMI, SMD, sarcopenia, and sarcopenic obesity) and survival and toxicity were assessed using univariable and multivariable Cox and logistic regression analyses, respectively.ResultsOf 88 patients, 75% was male, and median age was 63 (interquartile range 56–69) years. The majority of patients had an adenocarcinoma (83%). Before start of treatment, 49% of the patients were sarcopenic, and 20% had sarcopenic obesity. Low SMD was observed in 50% of patients. During three cycles CapOx, SMI significantly decreased, with a median decrease of 4% (interquartile range −8.6–−0.4). Median progression‐free and overall survival were 6.9 and 10.1 months. SMI, SMD, sarcopenia, and sarcopenic obesity (both pre‐treatment and after three cycles) were neither associated with progression‐free nor overall survival. Pre‐treatment SMD was independently associated with grade 3–4 toxicity (odds ratio 0.94; 95% confidence interval 0.89–1.00) and sarcopenic obesity with grade 2–4 neuropathy (odds ratio 3.82; 95% confidence interval 1.20–12.18).ConclusionsSarcopenia was not associated with survival or treatment‐related toxicity in advanced esophagogastric cancer patients treated with CapOx. Pre‐treatment sarcopenic obesity was independently associated with the occurrence of grade 2–4 neurotoxicity and skeletal muscle density with grade 3–4 toxicity.
Authentication of herbal drug Tukhm‐e‐balango (Lallemantia royleana Benth.) using microscopic, pharmacognostic, and phytochemical characterization
Authors: Rashid Sofia , Zafar Muhammad , Ahmad Mushtaq , Shinwari Muhammad Ibrar , Yaseen Ghulam , Sultana Shazia , Memon Rabia Asma , Zehra Syeda Alia , Wibawa Puto Agus Hendra 
Published: January 2019

AbstractThe study is aimed to provide a comprehensive account on authentication of herbal drug named as Tukhm‐e‐balango (Lallemantia royleana Benth.) from the seeds of Ocimum basilicum by using microscopic, pharmacognostic, and phytochemical characterization. The crude medicinal plants and their parts are often adulterated or substituted in market due to improper identification by the consumers while among herbal plant sellers, taxonomic confusion is caused due to morphological similarities of the plant parts and lack of a standard identification system.In microscopy, both herbarium and fresh specimens were studied using qualitative and quantitative morphological characteristics of leaves, seeds, and pollen. For pharmacognosy, solubility, fluorescence, and physicochemical characterizers were analyzed whereas a total phenolic and flavonoids contents was determined in addition to DPPH radical scavenging activity. In current study, microscopic, pharmacognostic, and phytochemical characterization clearly differentiated L. royleana from O. basilicum. The major problem in herbal drug industry is caused due to confusion and controversy of certain synonyms used for more than one or two drugs. Sometimes, under the same common or local name, entirely different taxa are being sold in herbal markets. It is concluded that correct and proper identification of medicinal plants is very crucial to ensure the safety and efficacy of herbal medicines, as many medicinal plants are intentionally or unintentionally adulterated with similar species or varieties. In herbal market, the seeds of L. royleana are adulterated with seeds of O. basilicum due to their similar morphology.
InGaAs/InP DHBT small‐signal model up to 325 GHz with two intrinsic base resistances
Authors: Chen Yapei , Zhang Yong , Li Xiao , Cheng Wei , Sun Yan , Lu Haiyan , Xiao Fei , Xu Ruimin 
Published: January 2019

AbstractIn this paper, a novel small‐signal equivalent‐circuit model of terahertz InGaAs/InP double‐heterojunction bipolar transistor (DHBT) is presented. Two intrinsic base resistances are introduced to represent the nonuniform extrinsic impedance of base‐emitter and base‐collector junctions separately. This treatment makes the high‐frequency model more close to the triple‐mesa InP DHBT structure. Systematical parasitic parameter extraction method and intrinsic element initialization of a 0.5 μm * 5μm InGaAs/InP DHBT are presented. As a high‐frequency device model, inter‐electrode parasitic capacitances are calculated by three‐dimensional electromagnetic simulation. The proposed model results in a good agreement with measured multibiased S‐parameters up to 325 GHz.