bluuebunny/crossref_metadata_2025_split huggingface dataset:
Goal-directed Fluid Therapy in Elderly Patients Undergoing Lumbar decompression surgery in the Prone Position: A Randomized Controlled Clinical Trial
Authors: XIA DI , Li Xu , Xu Li , Huang Yuguang 
Published: July 2019

Abstract
Background

Major lumber spine surgeries in the prone position have high mortality and morbidity, especially in elderly patients. Intraoperative goal-directed fluid therapy (GDT) has improved outcomes in abdominal and thoracic surgical procedures. However the utility of intraoperative GDT in spine surgery has not been present. In this study, we investigated whether GDT would reduce the postoperative complications in elderly patients undergoing lumbar stenosis decompression in the prone position.

Methods

In this single-center, randomized controlled clinical trial, we randomly assigned 84 patients aged > 60 undergoing lumbar decompression surgery to either a GDT group or a control group, who received conventional anesthesiologist-directed fluid therapy. Perioperative lactic acid concentrations with 7 different time point, intraoperative fluid balance and postoperative complications from admittance to 30 days after surgery were recorded.

Results

Lactic acid concentrations were higher in the control group than in the GTD group from the start of operation to 24 h after the operation, reaching maximum concentrations at exit from the post-anesthesia care unit (2.50 ± 1.22 mmol/l compared with 1.32 ± 0.42 mmol/l in controls; p<0.001). More total fluid volume was infused in GDT patients than in control patients (2416 ± 539 ml vs. 2036 ± 424ml, p<0.001). GDT patients had fewer infectious complications that did control patients (4.7% vs. 19.5%, P<0.001) after the surgery.

Conclusion

GDT during lumbar decompressive surgery under general anesthesia in elderly patients results in significantly better postoperative outcomes, which may be due to optimal fluid management and better perfusion of tissues and organs.

Trial registration
NCT02470221. Initial registration date was 06/09/2015.
Echocardiographic evaluation of total anomalous pulmonary venous connection: comparison of obstructed and unobstructed type
Authors: Xiang Yonghua , Zhang Xuehua , Qiu Jun , Gan Qing , Jin Ke 
Published: July 2019

Abstract
Purpose

The purpose of this study was to compare the differences between obstructed and unobstructed TAPVC using echocardiography, then to predict PVO by assessing clinical and echocardiographic parameters. Methods We conducted a retrospective study included 70 patients with TAPVC between 2014 and 2018. The morphological and hemodynamic echocardiographic parameters were observed and measured. The clinical and echocardiographic parameters that existed difference between obstructed and unobstructed TAPVC were selected to predict PVO by running ROC curve analysis. Results Between obstructed and unobstructed TAPVC, there were significant differences in ASD size, PA Vmax, MV VE, LVFS, LVEF, SV and the incidence of PDA, but there was no significant difference in birth weight. The first admission age of obstructed TAPVC was earlier than unobstructed type. The ROC curve analysis for the first admission age in predicting PVO showed the sensitivity and specificity were 76.7%, 80% respectively. The ROC curve analysis for multiple echocardiographic parameters showed the sensitivity and specificity were 82.6%, 100% respectively. Conclusions The presence of PVO led to anatomical and functional abnormity of patients with TAPVC, and then led to hospitalize earlier. The first admission age was a simple and feasible parameter in predicting PVO. The integrated use of multiple echocardiographic parameters had an excellent value in predicting PVO.
Analysis of the spatial distribution and clinical features of prostate cancer in transperineal prostate biopsy
Authors: Jia-Jun Chen , Zai-Sheng Zhu , Yi-Yi Zhu , Yi-Bo Zhou , Hong-Qi Shi 
Published: July 2019

Abstract
Background Recently, most studies on the spatial distribution of the prostate cancer are based on the samples confirmed by transrectal prostate biopsy (TRBx), which could distinguish the distribution of cancer lesions between the apex, middle and basal parts of the prostate, but the distinction between lesions in the left and right sides of prostate cancer and the transitional and peripheral bands remains to be considered. Further, there has been little research on the specific proportion of cancer in prostate biopsy tissue. The current study aimed to analyze the clinical characteristics, diagnostic efficacy of relevant indicators, and reveal the spatial distribution of prostate cancer in transperineal prostate biopsy (TPBx).

Methods A total of 810 patients underwent TPUS-guided 10-core prostate biopsy in our hospital from Oct. 2016-to Feb. 2019, participants' clinical data and the diagnostic yield of the cores were recorded and retrospectively analyzed as a cross-sectional study.

Results Age, total prostate specific antigen (t-PSA), prostate volume (PV), prostatic inflammation, dysuria, hematuria, asymptomatic and MRI were independent factors in prostate cancer (Pca) patients compared with non-Pca patients (P<0.05). The cut-off points for age, t-PSA, free prostate specific antigen (f-PSA), PSA density (PSAD), free/total prostate specific antigen (f/t PSA) and PV were 73years old, 15.43ng/ml, 4.545ng/ml, 0.475ng/ml*cm3, 0.123 and 41.45ml, respectively. The PRPN of left peripheral zone (LPZ) prostate tumor was elevated regardless of the Gleason score. However, the PRPN of left transitional zone (LTZ) was lower than LPZ and similar to right peripheral zone (RZ), but PRCF and CFVR were significantly higher, especially in tumors with higher Gleason score (≥8).

Conclusions For Chinese, the t-PSA standard and the PSAD standard in the puncture indication should be increased, while the f/t PSA standard should be reduced. At the same time, multi-factor assessment is needed to determine whether patients need a prostate biopsy or not. The spatial distribution of prostate cancer is asymmetrical, with more cancer lesion on the left than on the right. The PRPN of LPZ is relatively higher. LTZ has higher PRCF, and most of them were large lesions with high Gleason score (≥8).
Three-dimensional ultrasonography study of female defecation disorder caused by changes of the puborectalis muscle
Authors: Zhang Hui , Liu Kailun , Wang Zhimin , Kong Fanjuan , Gao Rongqing , Chen Lu , Li Yuantao , Pang Xue 
Published: July 2019

Abstract
Objective To investigate the correlation between pelvic floor dyssynergia-type constipation and the puborectalis muscle using three-dimensional ultrasonography. Methods Eighty-seven patients with pelvic floor dyssynergia-type constipation (observation group) and 87 healthy volunteers (control group) were enrolled in this study. Three-dimensional ultrasonography of the pelvic floor was performed on patients and healthy volunteers in a lithotomy position at rest and during straining and squeezing. The three-dimensional reconstructed sonogram was analysed to determine the puborectalis angle and puborectalis thickness at the 6 o’clock position (patients in a lithotomy position). Results (1) The puborectalis angles of the observation and control groups were not significantly different at rest [(85.664 ± 1.926)°, (85.813 ± 1.500)°] and during squeezing [(87.478 ± 2.125)°, (86.960 ± 1.751)°] (P > 0.05) but were significantly different when straining [(80.389 ± 2.268)°, (94.382 ± 1.540)°] (P < 0.05). The difference in the puborectalis angles of the two groups between rest and straining [(5.275 ± 1.236)°, (-8.569 ± 1.209)°] was statistically significant (P < 0.05). (2) The puborectalis thickness of the observation and control groups was not significantly different at rest ([3.994 ± 0.128) mm, (3.983 ± 0.091) mm] and during anal squeezing [(4.082 ± 0.154) mm, (4.126 ± 0.113) mm] (P > 0.05) but was significantly different when straining [(4.630 ± 0.199) mm, (4.296 ± 0.121) mm] (P < 0.05). The differences in the puborectalis thickness at rest and during straining in the observation and control groups were (-0.636 ± 0.217) mm and (-0.316 ± 0.089) mm, respectively, resulting in a statistically significant difference between the two groups (P < 0.05). Conclusion The puborectalis angle in patients with pelvic floor dyssynergia-type constipation was smaller than that in healthy volunteers during straining. The puborectalis thickness at the 6 o’clock position with the patient in a lithotomy position in patients with pelvic floor dyssynergia-type constipation was larger than that in healthy volunteers. Moreover, larger differences between rest and straining are associated with a more severe degree of constipation. Project funding Natural Science Foundation of Shandong (ZR2012HM086)
Benefits of a community based interdisciplinary learning exposure: A qualitative study of the One Health approach in teaching at Makerere University Uganda
Authors: Buregyeya Esther , Atusingwize Edwinah , Nsamba Peninah , Nalwadda Christine , Osuret Jimmy , Kalibala Patrick , Nuwamanya Ronald , Okech Samuel , Ssekamatte Tonny , Nitumusiima Sarah , Wakabi Timothy , Bikaako Winnie , Yawe Agnes , Naigaga Irene , Kagarama Juvenal , Kabasa John David , Bazeyo William 
Published: July 2019

Abstract
Makerere University implemented a One Health Institute (OHI) in 2016 involving undergraduate students selected from different disciplines. The students were first taken through theoretical principles in One Health followed by a field attachment in communities. The field attachment aimed to expose students to experiential educational opportunities in the communities in a One Health approach. In this paper, we present students’ experiences and their contributions to the communities of attachment.
Methods: This was a cross-sectional study, utilizing qualitative data collection methods. The study involved students who participated in the OHI field attachment and community members in Western Uganda. Four focus group discussions (FGDs) and four in-depths (IDIs) were conducted among the students, while four FGDs and eight IDIs were conducted among community members. All interviews were audio-recorded, transcribed and analysed manually.
Results
The four themes that emerged are: students’ understanding and appreciation of One Health concept, their experiences and gains from the multi-disciplinary field attachment, students’ contributions to the community, and challenges faced by the students. Students had good knowledge of One Health. They appreciated that health cannot be achieved by one discipline or sector and thus the need to collaborate across sectors. Regarding experiences and gains during the multi-disciplinary field attachment, the students appreciated that each discipline had a role to play in achieving health in the community. They appreciated the training sighting skills gained in communication, team work and collaboration. They also reported a feeling of gratitude and accomplishment because they felt they made a positive change to the community by putting in place interventions to address some of the community challenges. Similarly, the communities appreciated the students’ contribution in solving their health challenges, ranging from conducting health education to improving sanitation and hygiene.
Conclusions: Through the OHI, students gained One Health competencies including communication, teamwork, and collaboration. Adopting an interdisciplinary model in university teaching system especially during field placement would strengthen skills of collaboration, team work and communication which are critical for a multi-disciplinary approach which is needed among the future workforce in order to solve the current health challenges.
Malaria Outbreak Investigation in Argoba District, South Wello Zone, Northeast Ethiopia, 2016: A case control study
Authors: workie Getachew Yismaw , Tesema Getayeneh Antehunegn , Lakew Ayenew Molla , Akalu Temesgen Yihunie 
Published: July 2019

Abstract
Background

Malaria remains a major global public health concern and approximately half of the world’s population being at risk of infection. It is one of the common epidemic prone diseases and can result in continuous epidemics and end up with serious public health emergencies. Therefore, this study aimed at identifying determinants of malaria outbreak in Argoba district.

Methods

Community based case-control study was employed with a 1:1 case to control ratio at Argoba district from 21 June to 7 July, 2016. A total of 150 individuals (75 cases and 75 controls) were included in the study. Cases were taken from treatment registration book and neighborhoods to the cases were taken as control groups. Structured questionnaire was used as data collection tool. Data was entered using Epi-info version 7 statistical software and exported to STATA version 14 for analysis. A multivariable logistic regression analysis was used to identify determinants of the outbreak. The magnitude of the outbreak was described by place, person, and time. Adjusted Odds Ratios (AOR) with the corresponding 95% Confidence Interval (CI) was used to show the strength of associations and variables with P-values of <0.05 were considered statistically significant.

Results

The predominant Plasmodium species detected was P.falciparum, which is followed by P.vivax. The overall attack rate was 1.8%. Travel history to malarias site (AOR=14.6: 95% CI: 2.8, 77.7) and presence of mosquito breeding site around the home (less than 1000 meter) (AOR=13.3: 95% CI: 3.1, 58.0) were associated with the occurrence of malaria outbreak. However, using insecticide treated bed nets (AOR=0.004; 95% CI: 0.001, 0.06) and chemical indoor residual spray (AOR=0.02; 95% CI: 0.01, 0.09) were found to be protective factors.

Conclusions

malaria outbreak was affected by distance from the breeding site and traveling history of malaria endemic areas. In contrast, bed net utilization and house hold spray with DDT were preventive factors of the outbreak. It is recommended to use bed net utilization and house hold spraying in the district.
New Mineral Names*,†
Authors: Belakovskiy Dmitriy I. , Cámara Fernando , Gagné Olivier C. 
Published: July 2019

In this issue
This New Mineral Names has entries for 23 new minerals, including alpeite, ammoniozippeite, batagayite, centennialite, dagenaisite, davidsmithite, epifanovite, ferro-tschermakite, greenlizardite, grootfonteinite, janchevite, javorieite, kampelite, roymillerite, tredouxite, vanadio-pargasite, and wilancookite. Included also is a series of pyrochlore supergroup minerals: fluorcalciopyrochlore, hydroxycalciomicrolite, hydroxyferroroméite, hydroxykenoelsmoreite, hydroxynatropyrochlore, oxynatromicrolite along with a new data on hydrokenoelsmoreite-3C and hydrokenoelsmoreite-6R.
Plants and Phytocompounds Active Against Bothrops Venoms
Authors: Jorge Roberta Jeane Bezerra , Martins René Duarte , Araújo Renata Mendonça , da Silva Meykson Alexandre , Monteiro Helena Serra Azul , Ximenes Rafael Matos 
Published: July 2019

:Snakebite envenomation is an important health problem in tropical countries, with severe human and social consequences. In Latin America, the Bothrops species constitute the main threat to humans, and the envenomation caused by these species quickly develops into severe local tissue damage, including swelling, hemorrhaging, myonecrosis, skin ulceration, and pain. The systemic effects of envenomation are usually neutralized by antivenom serum therapy, despite its intrinsic risks. However, neutralization of local tissue damage remains a challenge. To improve actual therapy, two major alternatives are proposed: the rational design of new specific antibodies for most of the tissue damaging/ poor immunogenic toxins, or the search for new synthetic or natural compounds which are able to inhibit these toxins and complement the serum therapy. Natural compounds isolated from plants, mainly from those used in folk medicine to treat snakebite, are a good choice for finding new lead compounds to improve snakebite treatment and minimize its consequences for the victims. In this article, we reviewed the most promising plants and phytocompounds active against bothropic venoms.
Presentación
Authors: Oliver Costilla Lucio Fernando 
Published: July 2019

<p>El presente número aparece en un momento en que se siguen moviendo ciertas piezas clave del ajedrez latinoamericano y mundial, en un subcontinente sometido a la globalización excluyente, a los desmanes del neoliberalismo salvaje, bajo Estados en aguda crisis interna. La tónica no está, sin embargo, en la caída del crecimiento económico o en el aumento de la desigualdad, en la precariedad de sus instituciones o en las luchas en la sociedad política, cuyos actores, proyectos y políticas conocemos bastante bien por la subordinación de las élites dominantes a una transnacionalización de competencia y por sus intenciones siempre ajenas a las necesidades nacionales y populares, en una continua génesis de situaciones explosivas. La mirada de la revista está en otro ángulo: en la caracterización de la sociedad civil de los países de la subregión latinoamericana, un nuevo sujeto cada vez más presente y que cuenta con<br />una rica acumulación de experiencias, organización y conciencia; que actúa<br />decididamente, sin ser aún el elemento decisorio de lo público. Las sociedades civiles de América se asemejan a orugas vivientes saliendo del capullo, cuyas formas y colores son empero aún indefinidos y no se sabe qué tipo de transformación sufrirán en el futuro.</p>
Prebisch, Furtado e a Revolução Cubana
Authors: Camarinha Lopes Tiago , Almeida Filho Niemeyer , Henrique Pinto Gustavo Louis 
Published: July 2019

<p>Este artículo evalúa la relación entre Prebisch y Furtado en el contexto de la Revolución Cubana. La investigación parte de una lectura que separa el pensamiento cepalino de la estructura formal de la CEPAL encuadrada en el orden geopolítico de las Naciones Unidas. Esta lectura argumenta que, desde 1948, las estructuras originales del órgano delimitan las funciones objetivo de la comisión de acuerdo con la meta de mantener la estabilidad internacional. Esto hace que la CEPAL tenga, desde su origen, grandes dificultades para solucionar los problemas de desarrollo económico y social del continente, explicitando su contradicción de ser, al mismo tiempo, un generador de ideas económicas y un órgano subordinado a la estructura amplia de estabilidad del periodo posterior a la Segunda Guerra Mundial. Las tensiones entre Prebisch y Furtado fueron en buena medida resultado de los acontecimientos políticos en Cuba a partir de 1959, lo que refuerza la tesis contenida en esta lectura específica sobre la CEPAL.</p>
Imaginarios como saberes pertinentes en el proceso de enseñanza de la arquitectura. El caso del ecoturismo
Authors: Fregoso Lomas Sofía Constanza , Rodríguez Alcalá Antonio 
Published: July 2019

<p>Incorporar el tema de los imaginarios en el contexto de la enseñanza de la arquitectura tiene como propósito coadyuvar al desarrollo de las habilidades del pensamiento creativo en el estudiante de esta disciplina. En este texto, se propone que la lectura de los imaginarios del turismo durante el proceso de diseño en un taller de proyectos detona un proceso creativo no lineal, en tanto que aporta información del contexto sociocultural, al tiempo que informa sobre las determinantes de las prácticas turísticas (individual y colectiva) dentro de un grupo, lo cual permite dar respuestas integrales y holísticas de diseño enfocadas al usuario-grupo-contexto. De acuerdo con Irma Cantú, la creatividad en el proceso de diseño puede ser favorecida por estrategias que ayuden a desbloquear su desarrollo, al tiempo que la incrementan. En esta línea, la lectura, en particular de temas afines, impulsa las metáforas y analogías, las cuales son la base de una construcción teórica del concepto arquitectónico.</p>La naturaleza antropológica del imaginario nos sirve como herramienta epistemológica; permite acercarnos a cualquier fenómeno social complejo, revelarnos sus diferentes niveles de expresión, mostrarnos parte de su historia y el modo de relación con el contexto social y natural donde ocurre. Debido a que en los últimos treinta años hay una necesidad en la educación superior de incluir la dimensión ambiental (formulada más como una elección, como un imperativo) en los modelos educativos orientados al desarrollo sostenible, consideramos que con la revisión del imaginario del ecoturismo, a través de la descripción de su ideario, es posible contribuir a la ambientalización del currículo universitario en licenciaturas como Arquitectura. Finalmente, desde el punto de vista del diseño arquitectónico, proponemos que la complejidad estructural de un imaginario como representación mental de las creencias y modos de habitar<em> </em>de un grupo humano puede ser útil para la comprensión del usuario y las relaciones de habitabilidad que establece en un contexto específico.
The Position of NATO and Great Britain on the Crisis in Soviet-Romanian Relations During the Autumn 1968 As Reflected in British Documents
Authors: Zidaru Marian 
Published: July 2019

Abstract
During September-November 1968 there was a crisis situation in the Romanian-Soviet relations, generated by the criticism that the Romanian government formulated for the Soviet invasion of Czechoslovakia on August 23, 1968. This crisis came to the attention of decision-makers in the United Kingdom and Allied bodies within NATO. Both the British Cabinet and the representatives of the North Atlantic Alliance member countries held several meetings in which the issue of Romania and Yugoslavia was discussed in the context of Soviet threats. The Secretary of State of the Foreign Office visited Romania and discussed with Nicolae Ceauşescu, Ion Gheorghe Maurer and Corneliu Mănescu. This article aims to present debates within the NATO and the UK bodies on the political crisis in the Romanian-Soviet relations from the autumn of 1968 and the position adopted by them against a possible Soviet invasion in Romania and Yugoslavia.
Lieutenant-Colonel Constantin Apostol, A Glory of the Romanian Military Sport
Authors: Calcan Gheorghe 
Published: July 2019

Abstract
Lieutenant Colonel Constantin Apostol (1903-1995) was born in a family of wealthy peasants from Săgeata commune, Buzău County. His studies were: primary school in his native town, high school in Buzău, followed by military studies, namely The Cavalry Officers School from Târgoviște, The Special Cavalry School and The Equestrian School in Sibiu. His military career evolved as follows: from a high school student (1924) to being a caporal, a sergeant and a plutonier (1925), a sub-lieutenant (1927), a lieutenant (1930), a captain (1938), a major (1943) and, at the end of his activity, a colonel lieutenant (1946). Constantin Apostol was considered one of the most prestigious representatives of the Romanian horse riding. He was an instructor and a teacher at the Equestrian School in Sibiu and at the Superior School of War. In the interwar period, Constantin Apostol represented Romania at numerous international equestrian contests, winning many awards, including the first prize in tournements such as those from Aachen (The Great Trophy), Brussels, Belgrade, Berlin, Duseldorf, London, Munich, Naples, Nice, Paris, Rome, Warsaw, Vienna, etc. For such results, his name was mentioned several times in the Day Order. Constantin Apostol remained active even after his retirement, when, while in reserve, he prepared the Romanian national team for the Olympics in Helsinki and Stockholm (1952, 1956) and was also the coach of Petrolul Ploiești Sports Club.