bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fasting Plasma Glucose Indicates Reversibility of Acute Insulin Response after Short-Term Intensive Insulin Therapy in Patients with Type 2 Diabetes of Various Duration
Authors: LIU LIEHUA , YANG SIYUE , LIU JIANBIN , HAI LI , LIU JUAN , LI YANBING 
Published: June 2018

Objective: In patients with early type 2 diabetes, short-term intensive insulin therapy (SIIT) reverses ß cell dysfunction measured by acute insulin response (AIR). However, the complicated procedures limit large-scale use of AIR. Also unclear is whether SIIT is effective in patients with longer duration. This study is performed to assess fasting indicators estimating recovery of AIR after SIIT for type 2 diabetes of various duration.
Research Design and Methods: Patients with type 2 diabetes (n=62) who had poor glycemic control were enrolled. Near-nomoglycaemia was achieved and maintained for 7 days with insulin pump. AIR was measured by intravenous tolerance tests before and after SIIT.
Results: Both fasting plasma glucose (FPG, 12.0 ± 3.0 vs. 7.71± 1.6 mmol/L, P&lt;0.001) and 2h-postprandial glucose (17.3 ± 5.2 vs. 11.5 ± 3.7 mmol/L, P&lt;0.001) decreased significantly after SIIT. AIR was improved from -16.7 (-117.4, 52.4) pmol/L·min to 178.7 (31.8, 390.7) pmol/L·min (P&lt;0.001). Increase of AIR (?AIR)was observed in all disease duration categories (329.2±380.6, 312.8±347.8, and 123.8 ±186.3 pmol/L·min for patients with disease duration of &lt;2 years, 2-6 years, and &gt;6 years respectively, P=0.10). AIR was almost absent when FPG was over 10 mmol/L. However, when FPG after SIIT was less than 10 mmol/L it was negatively associated with AIR (R= -0.53, P&lt;0.001) and ?AIR (R= -0.52, P&lt;0.001). In multivariate analysis, AIR after the therapy and ?AIR could be estimated as follows: Estimated AIR (pmol/L·min) = 447.6 × baseline fasting C peptide (nmol/L) - 138.0× FPG after SIIT (mmol/L) + 925.2 (R2=0.42); estimated ?AIR (pmol/L·min) = 401.4 × baseline fasting C peptide (nmol/L) - 136.8 × FPG after SIIT (mmol/L) -357.6 × HDL-C after SIIT (mmol/L) + 1380.0(R2=0.50).
Conclusions: Recovery of AIR could be obtained in patients with various duration of type 2 diabetes, and it could be estimated conveniently by FPG and other fasting indicators.

Disclosure
L. Liu: None. S. Yang: None. J. Liu: None. L. Hai: None. J. Liu: None. Y. Li: None.
Baseline Characteristics of the Vitamin D and Type 2 Diabetes (D2d) Study: A Contemporary Prediabetes Cohort That Will Inform Diabetes Prevention Efforts
Authors: LeBlanc Erin S. , Pratley Richard E. , Dawson-Hughes Bess , Staten Myrlene A. , Sheehan Patricia R. , Lewis Michael R. , Peters Anne , Kim Sun H. , Chatterjee Ranee , Aroda Vanita R. , Chadha Chhavi , Neff Lisa M. , Brodsky Irwin G. , Rosen Clifford , Desouza Cyrus V. , Foreyt John P. , Hsia Daniel S. , Johnson Karen C. , Raskin Philip , Kashyap Sangeeta R. , O’Neil Patrick , Phillips Lawrence S. , Rasouli Neda , Liao Emilia P. , Robbins David C. , Pittas Anastassios G. ,   D2d Research Group, LeBlanc Erin S. , Pratley Richard E. , Dawson-Hughes Bess , Staten Myrlene A. , Sheehan Patricia R. , Lewis Michael R. , Peters Anne , Kim Sun H. , Chatterjee Ranee , Aroda Vanita R. , Chadha Chhavi , Neff Lisa M. , Brodsky Irwin G. , Rosen Clifford , Desouza Cyrus V. , Foreyt John P. , Hsia Daniel S. , Johnson Karen C. , Raskin Philip , Kashyap Sangeeta R. , O’Neil Patrick , Phillips Lawrence S. , Rasouli Neda , Liao Emilia P. , Robbins David C. , Pittas Anastassios G. 
Published: June 2018

OBJECTIVE
To describe baseline characteristics of the Vitamin D and Type 2 Diabetes (D2d) study, the first large U.S. diabetes prevention clinical trial to apply current American Diabetes Association (ADA) criteria for prediabetes.

RESEARCH DESIGN AND METHODS
This is a multicenter (n = 22 sites), randomized, double-blind, placebo-controlled, primary prevention clinical trial testing effects of oral daily 4,000 IU cholecalciferol (D3) compared with placebo on incident diabetes in U.S. adults at risk for diabetes. Eligible participants were at risk for diabetes, defined as not meeting criteria for diabetes but meeting at least two 2010 ADA glycemic criteria for prediabetes: fasting plasma glucose (FPG) 100–125 mg/dL, 2-h postload glucose (2hPG) after a 75-g oral glucose load 140–199 mg/dL, and/or a hemoglobin A1c (HbA1c) 5.7–6.4% (39–46 mmol/mol).

RESULTS
A total of 2,423 participants (45% of whom were women and 33% nonwhite) were randomized to cholecalciferol or placebo. Mean (SD) age was 60 (9.9) years and BMI 32.1 (4.5) kg/m2. Thirty-five percent met all three prediabetes criteria, 49% met the FPG/HbA1c criteria only, 9.5% met the 2hPG/FPG criteria only, and 6.3% met the 2hPG/HbA1c criteria only. Black participants had the highest mean HbA1c and lowest FPG concentration compared with white, Asian, and other races (P &lt; 0.01); 2hPG concentration did not differ among racial groups. When compared with previous prediabetes cohorts, the D2d cohort had lower mean 2hPG concentration but similar HbA1c and FPG concentrations.

CONCLUSIONS
D2d will establish whether vitamin D supplementation lowers risk of diabetes and will inform about the natural history of prediabetes per contemporary ADA criteria.
Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic Clamp
Authors:   The RISE Consortium, Ehrmann David A. , Temple Karla A. , Rue Abby , Barengolts Elena , Mokhlesi Babak , Van Cauter Eve , Sam Susan , Miller M. Annette , Kahn Steven E. , Atkinson Karen M. , Palmer Jerry P. , Utzschneider Kristina M. , Gebremedhin Tsige , Kernan-Schloss Abigail , Kozedub Alexandra , Montgomery Brenda K. , Morse Emily J. , Mather Kieren J. , Garrett Tammy , Hannon Tamara S. , Lteif Amale , Patel Aniket , Chisholm Robin , Moore Karen , Pirics Vivian , Pratt Linda , Nadeau Kristen J. , Gross Susan , Zeitler Philip S. , Williams Jayne , Cree-Green Melanie , Garcia Reyes Yesenia , Vissat Krista , Arslanian Silva A. , Brown Kathleen , Guerra Nancy , Porter Kristin , Caprio Sonia , Savoye Mary , Pierpont Bridget , Buchanan Thomas A. , Xiang Anny H. , Trigo Enrique , Beale Elizabeth , Hendee Fadi N. , Katkhouda Namir , Nayak Krishan , Martinez Mayra , Montgomery Cortney , Wang Xinhui , Edelstein Sharon L. , Lachin John M. , Hogan Ashley N. , Marcovina Santica , Harting Jessica , Albers John , Hill Dave , Savage Peter J. , Leschek Ellen W. 
Published: June 2018

OBJECTIVE
To compare insulin sensitivity (M/I) and β-cell responses in youth versus adults with impaired glucose tolerance (IGT) or drug-naïve, recently diagnosed type 2 diabetes.

RESEARCH DESIGN AND METHODS
In 66 youth (80.3% with IGT) and 355 adults (70.7% IGT), hyperglycemic clamps were used to measure 1) M/I, 2) acute (0–10 min [first phase]) C-peptide (ACPRg) and insulin (AIRg) responses to glucose, 3) steady-state C-peptide and insulin concentrations at plasma glucose of 11.1 mmol/L, and 4) arginine-stimulated maximum C-peptide (ACPRmax) and insulin (AIRmax) responses at plasma glucose &gt;25 mmol/L. The fasting C-peptide–to–insulin ratio was used as an estimate of insulin clearance.

RESULTS
Insulin sensitivity was 46% lower in youth compared with adults (P &lt; 0.001), and youth had greater acute and steady-state C-peptide (2.3- and 1.3-fold, respectively; each P &lt; 0.001) and insulin responses to glucose (AIRg 3.0-fold and steady state 2.2-fold; each P &lt; 0.001). Arginine-stimulated C-peptide and insulin responses were also greater in youth (1.6- and 1.7-fold, respectively; each P &lt; 0.001). After adjustment for insulin sensitivity, all β-cell responses remained significantly greater in youth. Insulin clearance was reduced in youth (P &lt; 0.001). Participants with diabetes had greater insulin sensitivity (P = 0.026), with lesser C-peptide and insulin responses than those with IGT (all P &lt; 0.001) but similar insulin clearance (P = 0.109).

CONCLUSIONS
In people with IGT or recently diagnosed diabetes, youth have lower insulin sensitivity, hyperresponsive β-cells, and reduced insulin clearance compared with adults. Whether these age-related differences contribute to declining β-cell function and/or impact responses to glucose-lowering interventions remains to be determined.
A NOVEL APPLICATION OF CHAOTIC PROPERTIES IN WATER TREATMENT PLANT
Authors: Natarajan Sridhar , Kumaar S. Senthil 
Published: June 2018

This paper aims at presenting a new optimization proposal to enhance the flocculation process in Water Treatment (WT) plant using a better flash mixing, located at KELAVERAPALLY, in Krishnagiri district, Tamil Nadu, India. Further, Sludge removal is done efficiently which decreases the water wastage as well as improvement in output water quality. Though WT plants are already equipped with systematic and sequential physicochemical processes, still they need to be optimized to obtain a better treated drinking water to maintain the quality standards as prescribed by World Health Organization. Chaotic behavior in chemical systems has been used to optimize the performance of WT plant. Measurement systems implemented in WT plant yield several chaotic based measurement parameters which are used to control the system operations to maintain the target water quality.Â This intelligible data extraction through the proposed measurement Â systems in a short span of time improves the plant performance without adding any costly systems except few changes in the existing plant setup. Â Chaotic behavior is ensured through Lyapunov Exponents and Kolmogorov-Sinai Entropies. Both, water quality improvement and water wastage reduction is achieved simultaneously in the proposed work when a dosage prediction is done using Feed Forward Neural Networks. The treatment plant investigated has a maximum capacity of 14 MLD (Million litres per day) using two parallel streams with 7 MLD each
Creating Legal Certainty in Sharia Banking Law Systems through the Embodiment of Sharia Compliance Principle
Authors: Nasikhin Muh. ,   Muhaimin, Haq L. M. Hayyanul , Asikin Zainal 
Published: June 2018

Abstract
This work is aimed at creating legal certainty sharia compliance arrangements in sharia banking law systems. This idea is highly required to improve the credibility of the sharia-based business activities. Certainly, this study is relevant to solve some normative problems in regulating and managing of the sharia banking activities, particularly regarding sharia compliance. In detail those normative problems can be seen from the inconsistence and ambiguous norms, conflicted norms and legal vacuum in regulating sharia compliance principle. To visualize and elaborate the above issues, these works apply normative legal research, where all data are collected through intensive and extensive literature review. Those data will be analysed by philosophical, statute and conceptual approach. The core issues that will be elaborated in this work are: (i) formulating Islamic values to the some relevant sharia banking law principles; (ii) some normative problems construction of sharia compliance principles in sharia banking law systems; (iii) reconstructing of regulating sharia compliance principles to creating legal certainty. At the end, this work will offer appropriate model in coherence those normative problems in order to creating legal certainty in managing and regulating sharia banking law.
The Importance of Human Resources in Corporate Governance
Authors: Athmen Bouziane , Samia Belhadef 
Published: June 2018

Abstract
The purpose of this research is to clarify the status of human resources in terms of corporate governance through chart analyses. These analyses are based on theoretical principles that clarify the relationship between human resources and corporate governance, and they are divided based on two perspectives. The first one is the corporate governance perspective, and the second is that of the human resources, whereas the administrative board is considered as a common point between them. Human resources is one the most important points that must be addressed by corporate governance. The literature review of this study includes the theories and models of corporate governance, such as the Agency Theory, and the Theory of Stakeholders, and Shareholders Model. As for the literary sources for the study of human resources, they include articles specialized in the study of corporate governance and human resources to analyze the relationship between them based on a series of methodological steps including the literature review and the collection of relevant data from primary and secondary sources.
The Comparison of Tnf α (Tumor Necrosis Factor α) Serum Levels Between Cytotoxin - Associated Gene A (Caga) Positive and Negative in Patients with Gastritis Helicobacter pylori
Authors: Karo Fitri Armanti , Dairi Leonardo Basa , Siregar Gontar Alamsyah 
Published: June 2018

Background: Helicobacter pylori (H. pylori) infection is the common cause of chronic gastritis in the world that is around 80% in addition to other causes such as autoimmune diseases, drugs, idiopathic and others. The pathogenesis of H. pylori associated with virulence factors consisting of cytotoxin - associated gene A (CagA) and vacuolating cytotoxin A (Vaca). In the case of gastritis occurred acute and chronic inflammatory responses and activation cytokines that cause inflammation of mucous which TNF-α levels increased in patients gatritis H. pylori. Levels of serum TNF-α was found higher in patients infected with H. pylori with CagA positive. The purpose of this study is to investigate the comparison between TNF-α serum level in H. pylori gastritis patients with Cag A (+) and CagA (-).Method: The study was conducted with a cross-sectional design in 30 patients with dyspepsia, using PADYQ score. We performed gastroscopy, biopsy, and CLO test to prove the existence of H. pylori. Furthermore, we used PCR to assess CagA (+) and CagA (-), and ELISA method to measure TNF-α serum level.Results: From 30 subjects, 18 men (60%), 12 women (40%), and the mean age was 53.5 years, the majority of the ethnic was Bataknese (53.3%), patients with H. pylori gastritis with CagA (+) were 21 (70%) and patients with H. pylori gastritis with CagA (-) were 9 (30%). We found the mean serum levels of TNF-α was higher (3.48) in H. pylori gastritis with CagA (+) than the CagA (-) (1.29) with p value was 0.001.Conclusion: We found increased serum levels of TNF-α in patients with CagA (+) compared to Cag A (-) H. pylori gastritis.
Effects of Curcumin Against Matrix Metalloproteinase-2 (MMP-2) and Tissue Inhibitor Metalloproteinase-2 (TIMP-2) Serum Level on Rat Model of Liver Fibrosis Resolution Process
Authors: Supriono Supriono , Pratomo Bogi , Kriestian Muhammad 
Published: June 2018

Background: Liver fibrosis is an effect from continuous fibrogenesis and fibrolysis process. During fibrogenesis, MMP-2 and TIMP-2 that produced by hepatic stellate cell (HSC) have a role to regulate extracellular matrix (ECM) homeostastic. Otherwise, curcumin inhibits both MMP-2 and TIMP-2 expression and enhances HSC apoptosis, thus inhibit fibrogenesis. Role of curcumin, MMP-2, and TIMP-2 in a fibrolysis process has not been widely studied. This study aimed to determine the correlation between curcumin administration and the decline of MMP-2 and TIMP-2 on rat model of liver fibrosis.Method: This is an experimental study done in male Wistar rats. There are 8 groups consist of 4 rats each. Both control and intervention group were exposed to CCl4 1 cc/kgBW intraperitoneally 2 times per week for 9 consecutive weeks to form F3 fibrosis. Negative control group was injected with normal saline. After CCl4 injection, control group was given curcumin solvent as placebo while intervention groups were given curcumin 200 mg/kgBW for 2, 5, and 9 weeks. Statistical analysis then conducted in the end of study. Results: MMP-2 and TIMP-2 were remarkably increased in positive control group, but found decreased in control group 5 and 9. There are remarkable decrease of MMP-2 and TIMP-2 serum level in intervention group 2, 5, and 9, but MMP-2 and TIMP-2 level was significantly lower in intervention group 2 compared to the control group.Conclusion: MMP-2 and TIMP-2 serum level were decreased after giving of curcumin for 2 weeks. The duration of curcumin administration correlated with decrease of TIMP-2 serum level but not correlated with MMP-2 serum level in rat model of liver fibrosis.
ENDOSCOPIC PHOTODYNAMIC THERAPY OF A PATIENT WITH LUNG CANCER METASTASIS IN BIFURCATION LYMPH NODES (CLINICAL OBSERVATION)
Authors: Legostaev V. M. , Babenkov O. Yu. , Balitskiy G. V. 
Published: June 2018

AbstractThis clinical case demonstrates the feasibility of photodynamic therapy (PDT) as a method of choosing the treatment of recurrent lung cancer in inoperable patients with ineffective chemoradiotherapy. An operation was performed on the patient with a diagnosis of pT4N0M0 central cancer of the lower lobe of the right lung after 2 courses of neoadjuvant chemotherapy in October 2015: an expanded combined lower bilobectomy of the right lung, with resection of the pericardium and left atrium. Then 4 courses of adjuvant chemotherapy (cisplatin + vinorelbine) and a course of radiotherapy on the mediastinum area up to a total dose of 45 Gy were carried out. After 2 months, a metastatic lesion of bifurcation lymph nodes with invasion of the mucosa of the tracheal bifurcation, involving the distal trachea, proximal right and left main bronchi was detected. The result of histological analysis: G2 squamous cell carcinoma without keratinization. From Dec 2016 to Jun 2017, the patient underwent 5 courses of PDT, as a result of which a significant cytoreductive effect and stabilization of the process were achieved. The continuation of the PDT treatment is planned.
Research on The Application of Foresight in The Development of Strategies and Policies for Management of Natural Resources and Environment in Vietnam
Authors: Hoàng Thanh Hương 
Published: June 2018

Vietnam is facing serious environmental and resource issues that directly affect the community. Therefore, in the current context, management must have immediate and long-term orientations in the formulation of strategies and policies, so that, we need to do well the forecasting work. In contrast to the closed approach of traditional forecasting approach, the foresight approach is seen as a way of communicating, exchanging and negotiating among different parts of society, thereby discovering scientific, economic, cultural and social value contributes to the general society in the future, while integrating in the process of forecasting issues to be discussed, evaluated, analyzed and proposed. The Vietnamese policy has not now achieved the desired effect. Thus, foresight can be considered as a new approach to support forecasting in the development of the sector strategy for natural resources and environment.
The paper focuses on some of the world's foresight approaches and attempts to answer two questions: (i) How does this approach be used in the development of the strategy? (ii) Applicability in forecasting strategies and policy formulation in Vietnam. Answers to these two questions will provide recommendations so that be able to apply this approach for the development of the strategy and policy on natural resources and the environment in Vietnam.
THE INFLUENCE OF TOP-DOWN STRATEGY (TDS) ON STUDENTS’ READING COMPREHENSION
Authors: Prasetyo Dwi Darsa , Syam Ummi Khaerati , Saiful Saiful , Sangkala Ismail 
Published: June 2018

This research aimed to find out the influence of Top-Down Strategy (TDS) on students reading comprehension that focus on level of literal and interpretative of comprehension. The researcher applied pre-experimental method with one group pre-test and post-test. The sample of this research was class XI MIA 2 of SMA Negeri 10 GOWA which consisted of 30 students. The sample was taken by using purposive sampling method. The result of the research were the mean score of pretest in Literal (main Idea) score of pretest was 58.6 and post-test was 86.56. In sequence of detail the score of pretest was 56.4 and post-test was 92.6 with t-test value Literal is greater than t-table (13.26 > 2.45). Mean score of intrepretative in pretest was 63.63 and post-test was 82 with the t-test value is greater that t-table (8.34 >2.45). The result of calculating t-test of the indicators in the students’-test (Literal and Interpretative) was greater than t-table 21.60 > 2.45. it means that there was significance different between before and after giving the treatment. Based on explanation above we concluded that using Top-Down Strategy is influence and improve students reading comprehension especially in literal and interpretative levels.
Pemodelan pada Proses Cyclostationarity Berdasarkan Data Pasut Cilacap Tahun 2007-2015
Authors: Cendani Larasati S. , Perbani N.M.R.R. Cahya , Sawitri Kania 
Published: June 2018

ABSTRAK Sesuai prosedur dalam penentuan MSL sejati, pengamatan pasut dilakukan secara terus-menerus selama 18,61 tahun dengan selang waktu satu jam tanpa jeda. Pengamatan pasut tersebut bukanlah suatu hal yang mudah dan hampir tidak dapat untuk dilakukan, MSL yang digunakan untuk kepentingan teknis umumnya ditentukan berdasarkan data pengamatan pasut periode pendek selama 15 atau 29 hari. Periode pendek tersebut memiliki keterbatasan dalam mengakomodasi seluruh faktor yang mempengaruhi MSL. Hipotesis pada penelitian ini MSL bulanan juga memiliki sifat cyclostationarity berdasarkan penelitian pasang tinggi di Benoa, Bali yang memiliki sifat yang sama. Penelitian ini bertujuan memodelkan terjadinya proses cyclostationarity untuk dijadikan sebagai model koreksi mean sea level bulanan dan untuk mengetahui variasi yang terjadi. Pemodelan dilakukan menggunakan fungsi gelombang dua konstanta pasut periode panjang Sa dan Ssa menggunakan analisis harmonik kuadrat terkecil melalui Deret Fourier. Dari penelitian yang telah dilakukan diketahui bahwa model gelombang yang dihasilkan sudah 80% mewakili perilaku MSL bulanan dan simpangan maksimum terhadap MSL bulanan rata-rata sebesar 245 mm. Kata kunci: MSL bulanan, cyclostationarity, fungsi gelombang ABSTRACT In procedure to determine the true mean sea level (MSL), hourly tide measurement should be taken for 18,61 years continuously. That such measurement is not simple and barely possible to establish. In most technical cases, MSL is determined from shot period measurement 15 or 29 days. The limitation of that such short period data is in accommodating all factors with action MSL. In this study the monthly MSL is a cyclostationarity process like spring tides in Benoa, Bali is taken as the hypothesis. This study directed to model cyclostationarity process to build the model of monthly MSL and to find it’s variation. The modeling is accomplished using wave function two long period constituents (Sa and Ssa). Least square harmonic analysis by means of Fourier series is applied. It is found that the wave model from this study represent about 80% of monthly MSL behavior and the average of maximum deviation is 245 mm. Keywords: monthly MSL, cyclostationarity, wave function