bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissociation of fear initiation and maintenance by breathing-driven prefrontal oscillations
Authors: Bagur Sophie , Lefort Julie M. , Lacroix Marie M. , de Lavilléon Gaëtan , Herry Cyril , Billand Clara , Geoffroy Hélène , Benchenane Karim 
Published: November 2018

AbstractDoes the body play an active role in emotions? Since the original James/Cannon controversy this debate has mainly been fueled by introspective accounts of human experience. Here, we use the animal model to demonstrate a physiological mechanism for bodily feedback and its causal role in the stabilization of emotional states. We report that during fear-related freezing mice breathe at 4Hz and show, using probabilistic modelling, that optogenetic perturbation of this feedback specifically reduces freezing maintenance without impacting its initiation. This rhythm is transmitted by the olfactory bulb to the prefrontal cortex where it organizes neural firing and optogenetic probing of the circuit demonstrates frequency-specific tuning that maximizes prefrontal cortex responsivity at 4Hz, the breathing frequency during freezing. These results point to a brain-body-brain loop in which the initiation of emotional behavior engenders somatic changes which then feedback to the cortex to directly participate in sustaining emotional states.
Computational metabolism modeling predicts risk of distant relapse-free survival in breast cancer patients
Authors: Trilla-Fuertes Lucía , Gámez-Pozo Angelo , Díaz-Almirón Mariana , Prado-Vázquez Guillermo , Zapater-Moros Andrea , López-Vacas Rocío , Nanni Paolo , Zamora Pilar , Espinosa Enrique , Vara Juan Ángel Fresno 
Published: November 2018

AbstractAims:Differences in metabolism among breast cancer subtypes suggest that metabolism plays an important role in this disease. Flux Balance Analysis is used to explore these differences as well as drug response.Materials & Methods:Proteomics data from breast tumors were obtained by mass-spectrometry. Flux Balance Analysis was performed to study metabolic networks. Flux activities from metabolic pathways were calculated and used to build prognostic models.Results:Flux activities of vitamin A, tetrahydrobiopterin and beta-alanine metabolism pathways split our population into low- and high-risk patients. Additionally, flux activities of glycolysis and glutamate metabolism split triple negative tumors into low- and high-risk groups.Conclusions:Flux activities summarize Flux Balance Analysis data and can be associated with prognosis in cancer.
Identifying the diagnostic value of microRNA-421 in gastric cancer patients: a meta-analysis
Authors: Miao Yan , Zhang Ying , Wang Lina , Yin Lihong 
Published: November 2018

ABSTRACTObjectivesEmerging evidence has shown that the expression level of microRNA-421 (miR-421) was significantly different between gastric cancer (GC) patients and healthy individuals. However, the diagnostic accuracy of miR-421 in the reports remains inconsistent. This meta-analysis aims to assess the diagnostic value of miR-421 in GC detection.MethodsAll related articles on miR-421 in GC diagnosis were retrieved until September 2018. The QUADAS-2 checklist was used to assess the methodological quality of each study. The diagnostic performance of miR-421 for GC were assessed by using Meta-DiSc 1.4 and STATA 14.0 statistical software.ResultsA total of 172 GC patients and 154 healthy controls from three articles (four studies) were enrolled in this meta-analysis. The results of pooled sensitivity, specificity, diagnostic odds ratio (DOR) with 95% confidence interval (CI) were 0.90 (95% CI: 0.85 to 0.93), 0.83 (95% CI: 0.77 to 0.87), and 37.18 (95% CI: 8.61 to 160.49), respectively. The area under the summary receiver operating characteristic curve (SROC) was 0.8977.ConclusionsThis study indicates that miR-421 could serve as a promising biomarker for GC detecting. Further studies are needed to verify the generalizability of these findings.
Impact of a Patient-Derived Hepatitis C Viral RNA Genome with a Mutated MicroRNA Binding Site
Authors: Mata Miguel , Neben Steven , Majzoub Karim , Carette Jan , Sarnow Peter 
Published: November 2018

AbstractHepatitis C virus (HCV) depends on liver-specific microRNA miR-122 for efficient viral RNA amplification in liver cells. This microRNA interacts with two different conserved sites at the very 5’ end of the viral RNA, enhancing miR-122 stability and promoting replication of the viral RNA. Treatment of HCV patients with oligonucleotides that sequester mir-122 resulted in profound loss of viral RNA in phase II clinical trials. However, some patients accumulated in their sera a viral RNA genome that contained a single cytidine to uridine mutation at the third nucleotide from the 5’ genomic end. It is shown here that this C3U variant indeed displayed higher rates of replication than that of wild-type HCV when miR-122 abundance is low in liver cells. However, when miR-122 abundance is high, binding of miR-122 to site 1, most proximal to the 5’ end in the C3U variant RNA, is impaired without disrupting the binding of miR-122 to site 2. As a result, C3U RNA displays a much lower rate of replication than wild-type mRNA when miR-122 abundance is high in the liver. These findings suggest that sequestration of miR-122 leads to a resistance-associated mutation that has only been observed in treated patients so far, and raises the question about the function of the C3U variant in the peripheral blood.Author SummaryWith the advent of potent direct-acting antivirals (DAA), hepatitis C virus (HCV) can now be eliminated from the majority of patients, using multidrug therapy with DAAs. However, such DAAs are not available for the treatment of most RNA virus infections. The main problem is the high error rate by which RNA-dependent RNA polymerases copy viral RNA genomes, allowing the selection of mutations that are resistant to DAAs. Thus, targeting host-encoded functions that are essential for growth of the virus but not for the host cell offer promising, novel approaches. HCV needs host-encoded microRNA miR-122 for its viral RNA replication in the liver, and depletion of miR-122 in HCV patients results in loss of viral RNA. This study shows that a single-nucleotide mutation in HCV allows viral RNA amplification when miR-122 abundances are low, concomitant with changes in its tropism.
Impact analysis and adaptive sliding mode control for cislunar payload transportation using spinning tether system
Authors: Lu Hongshi , Aijun Li , Changqing Wang , Yuriy Zabolotnov Michaelovitch 
Published: November 2018

Purpose
This paper aims to present the impact analysis of payload rendezvous with tethered satellite system and the design of an adaptive sliding mode controller which can deal with mass parameter uncertainty of targeted payload, so that the proposed cislunar transportation scheme with spinning tether system could be extended to a wider and more practical range.

Design/methodology/approach
In this work, dynamical model is first derived based on Langrangian equations to describe the motion of a spinning tether system in an arbitrary Keplerian orbit, which takes the mass of spacecraft, tether and payload into account. Orbital design and optimal open-loop control for the payload tossed by the spinning tether system are then presented. The real payload rendezvous impact around docking point is also analyzed. Based on reference acceleration trajectory given by optimal theories, a sliding mode controller with saturation functions is designed in the close-loop control of payload tossing stage under initial disturbance caused by actual rendezvous error. To alleviate the influence of inaccurate/unknown payload mass parameters, the adaptive law is designed and integrated into sliding mode controller. Finally, the performance of the proposed controller is evaluated using simulations. Simulation results validate that proposed controller is found effective in driving the spinning tether system to carry payload into desired cislunar transfer orbit and in dealing with payload mass parameter uncertainty in a relatively large range.

Findings
The results show that unideal rendezvous manoeuvres have significant impact on in-plane motion of spinning tether system, and the proposed adaptive sliding mode controller with saturation functions not only guarantees the stability but also provides good performance and robustness against the parameter and unstructured uncertainties.

Originality/value
This work addresses the analysis of actual impact on spinning tether system motion when payload is docking with system within tolerated docking window, rather than at the particular ideal docking point, and the robust tracking control of deep-space payload tossing missions with the spinning tether system using the adaptive sliding mode controller dealing with parameter uncertainties. This combination has not been proposed before for tracking control of multivariable spinning tether systems.
Enabling energy-efficient renovation: the case of vertical extension to buildings
Authors: Sundling Rikard , Blomsterberg Åke , Landin Anne 
Published: November 2018

Purpose
This paper is based on a study of six similar buildings built in Gothenburg, Sweden, in 1971, which were in urgent need of renovation. A life cycle profit analysis shows how four competing concepts were evaluated to find a financially viable renovation concept; additionally, the environmental impacts of these renovation concepts using a life cycle assessment are presented.

Design/methodology/approach
Four renovation concepts are compared to find the most appropriate concept, namely, minimalist, code-compliant, low-energy and low-energy plus vertical extension concepts. The methods used for comparison are life cycle profit analysis and life cycle impact assessment; the methods used for data gathering included site visits, interviews, document study, co-benefits study and energy simulation.

Findings
The findings show that vertical extension supported the energy-efficient renovation of the buildings and that the combination of low-energy and the vertical extension had the highest return on investment and the lowest environmental impact. The selected concept for renovating the remaining five buildings combined was the low-energy plus vertical extension. Additional benefits from vertical extension include more apartments in central locations for the housing company, a wider variety of apartment layouts and a wider range of tenants. Drawbacks include increased use of infrastructure, green space and common appliances, as well as gentrification.

Originality/value
This study shows how a vertical extension can financially enable an energy-efficient renovation and further lower its environmental impact. Benefits and drawbacks of densification are also highlighted to better understand the implementation of vertically extending a building.
The Italian breakfast: Mulino Bianco and the advent of a family practice (1971-1995)
Authors: Pirani Daniela , Cappellini Benedetta , Harman Vicki 
Published: November 2018

PurposeThis paper aims to examine how Mulino Bianco, an iconic Italian bakery brand, has reshaped the symbolic and material aspects of breakfast in Italy, transforming a declining practice into a common family occasion.Design/methodology/approachA socio-historical analysis of the iconisation process has been undertaken with a framework for investigating the symbolic, material and practice-based aspects of the brand and their changes over time. Archival marketing material, advertising campaigns and interviews with brand managers constitute the main data for analysis.FindingsThree crucial moments have been identified in which the brand articulates its relationship with the practice of breakfast. During the launch of the brand, the articulation was mainly instigated via the myths of tamed nature and rural past and the material aspect of the products reinforced such an articulation. In the second moment, the articulation was established with the brand’s materiality, emphasised through the use of promotional items targeting mothers and children. In the last phase, a cementification of the articulation was achieved mainly via the symbolic aspect of the brand – communicating Mulino Bianco as emblematic of a new family life in which the “Italian breakfast” was central.Originality/valueTheoretically, this paper advances the understanding of the pervasive influence of brands in family life, showing how they do not simply reshape existing family food practices, rather they can re-create new ones, investing them with symbolic meanings, anchoring them with novel materiality and equipping consumers with new understandings and competences.
Towards digital scholarship services in China’s university libraries
Authors: Zhou Lihong , Huang Ruhua , Zijlstra Tim 
Published: November 2018

Purpose
This paper aims to report on a literature review that aimed to establish a guiding framework for the development of digital scholarship services in China’s university libraries.

Design/methodology/approach
The framework was developed through systematically searching, screening, assessing, coding and aggregating digital scholarship services as reported in the existing body of literature. Three types of literature were included in the analysis: international academic literature as reported in English; academic literature in Chinese; and relevant professional reports.

Findings
The literature analysis pointed to 25 different digital scholarship services, which emerged in six themes: supporting services, formulating research ideas, locating research partners, writing proposals, conducting research and publishing results.

Originality/value
Although this literature review focused on university libraries in China, the research findings and the guiding framework developed provide useful insights and indications that can be shared across international borders.
Natural convection of Bingham fluids in rectangular cross-sectional cylindrical annuli with differentially heated vertical walls
Authors: Yigit Sahin , Chakraborty Nilanjan 
Published: November 2018

PurposeThis paper aims to numerically analyse natural convection of yield stress fluids in rectangular cross-sectional cylindrical annular enclosures. The laminar steady-state simulations have been conducted for a range of different values of normalised internal radius (ri/L1/8 to 16, whereLis the difference between outer and inner radii); aspect ratio (AR=H/Lfrom 1/8 to 8 whereHis the enclosure height); and nominal Rayleigh number (Rafrom 103to 106) for a single representative value of Prandtl number (Pris 500).Design/methodology/approachThe Bingham model has been used to mimic the yield stress fluid motion, and numerical simulations have been conducted for both constant wall temperature (CWT) and constant wall heat flux (CWHF) boundary conditions for the vertical side walls. The conservation equations of mass, momentum and energy have been solved in a coupled manner using the finite volume method where a second-order central differencing scheme is used for the diffusive terms and a second-order up-wind scheme is used for the convective terms. The well-known semi-implicit method for pressure-linked equations algorithm is used for the coupling of the pressure and velocity.FindingsIt is found that the mean Nusselt number based on the inner peripheryNu¯iincreases (decreases) with an increase inRa(Bn) due to augmented buoyancy (viscous) forces irrespective of the boundary condition. The ratio of convective to diffusive thermal transport increases with increasingri/Lfor both Newtonian (i.e.Bn= 0) and Bingham fluids regardless of the boundary condition. Moreover, the mean Nusselt numberNu¯inormalised by the corresponding Nusselt number due to pure conductive transport (i.e.Nu¯i/(Nu¯i)cond) shows a non-monotonic trend with increasingARin the CWT configuration for a given set of values ofRa,Pr,Lifor both Newtonian (i.e.Bn= 0) and Bingham fluids, whereasNu¯i/(Nu¯i)condincreases monotonically with increasingARin the CWHF configuration. The influences of convective thermal transport strengthen while thermal diffusive transport weakens with increasingAR, and these competing effects are responsible for the non-monotonicNu¯i/(Nu¯i)condvariation withARin the CWT configuration.Originality/valueDetailed scaling analysis is utilised to explain the observed influences ofRa,BN,ri/LandAR, which along with the simulation data has been used to propose correlations forNu¯i.
Anomaly data management and big data analytics: an application on disability datasets
Authors: Pan Zhiwen , Ji Wen , Chen Yiqiang , Dai Lianjun , Zhang Jun 
Published: November 2018

Purpose
The disability datasets are the datasets that contain the information of disabled populations. By analyzing these datasets, professionals who work with disabled populations can have a better understanding of the inherent characteristics of the disabled populations, so that working plans and policies, which can effectively help the disabled populations, can be made accordingly.

Design/methodology/approach
In this paper, the authors proposed a big data management and analytic approach for disability datasets.

Findings
By using a set of data mining algorithms, the proposed approach can provide the following services. The data management scheme in the approach can improve the quality of disability data by estimating miss attribute values and detecting anomaly and low-quality data instances. The data mining scheme in the approach can explore useful patterns which reflect the correlation, association and interactional between the disability data attributes. Experiments based on real-world dataset are conducted at the end to prove the effectiveness of the approach.

Originality/value
The proposed approach can enable data-driven decision-making for professionals who work with disabled populations.
Impact of internal branding on customer-based brand equity with mediating effect of organizational loyalty
Authors: Hasni Muhammad Junaid Shahid , Salo Jari , Naeem Hummayoun , Abbasi Kashif Shafique 
Published: November 2018

PurposeBranding has become a permanent source of competitive advantage for any leading business. Predominantly, it is execution inside the organization for employees. The purpose of this paper is to measure the influence of internal branding (IB) on customers-based brand equity (CBBE) and the mediating effect of organizational loyalty (OL) between two retail store chains of an under developing country (e.g. Pakistan).Design/methodology/approachThis paper draws on primary data. Data were collected from frontline officers and customers of selected retail stores. Descriptive analysis, mediation analysis and independent samplet-test data analysis techniques were applied through smart PLS and SPSS.FindingsThe results of the study revealed that IB influences OL and CBBE. The outcomes showed the mediation effect of OL on the relationship between IB and CBBE partially. Furthermore, results of this papers also disclosed a difference in the levels of IB and OL in both organizations. But, there was no difference in the level of brand equity among customers of both retail stores.Practical implicationsThe retail store sector is growing at fast pace with new innovations in all dimensions of the sector. These results could help the retail industry with empirical pieces of evidence to implement IB in their organizations to make the strong relationship between store and customer through efficient and well-trained frontline officers.Originality/valueThe study’s noteworthy contribution to the industry and academic world is the empirical support for the relationship between IB and CBBE. This study has explored the IB in the service sector (i.e. the retail store) from the non-western and under developing context.
Mobile learning analytics in higher education: usability testing and evaluation of an app prototype
Authors: Kuhnel Matthias , Seiler Luisa , Honal Andrea , Ifenthaler Dirk 
Published: November 2018

Purpose
The purpose of the study was to test the usability of the MyLA app prototype by its potential users. Furthermore, the Web app will be introduced in the framework of “Mobile Learning Analytics”, a cooperation project between the Cooperative State University Mannheim and University of Mannheim. The participating universities focus on the support of personalized and self-regulated learning. MyLA collects data such as learning behavior, as well as personality traits. Last but not least, the paper will contribute to the topic of learning analytics and mobile learning in higher education.

Design/methodology
For the empirical investigation, a mixed-method design was chosen. While 105 participants took part in the conducted online survey, after testing the app prototype, seven students joined an additional eye tracking study. For the quantitative part, a selected question pool from HIMATT (highly integrated model assessment technology and tools) instrument was chosen. The eye tracking investigation consisted of three tasks the participants had to solve.

Findings
The findings showed that the students assessed the idea of the app, as well as the navigation positively. Only the color scheme of the prototype was not very attractive to a noticeable amount of the participants. So, it requires slight modifications concerning the app design. For the eye tracking study, it can be stated that the students viewed the relevant parts, and they basically had no difficulties to solve the tasks.

Originality/value
Due to the empirical testing of the app prototype, the project team was able to adjust the application and to add further features. Furthermore, the backend was programmed and an additional tool (MyLA dashboard) was developed for lecturers. A mutual understanding of the targets, privacy issue and relevant features are indispensable for further development of the project.
Institutions, agency, culture and control: a case study of a multinational operating company
Authors: Kapiyangoda Kumudu , Gooneratne Tharusha 
Published: November 2018

PurposeThis paper aims to explore how management control systems (MCS) of an operating company (Delta Lanka) of a multinational corporation (MNC) is shaped through the interplay between external institutional influences via global prescriptions stemming from the parent company culture and localisation needs as suited to cultural context of the operating company through the agency of practice level actors.Design/methodology/approachTheoretically, the paper draws upon institutional theory, more specifically the notions of external institutions and agency of practice level actors, while methodologically, it adopts the single-site case study approach under the qualitative tradition.FindingsThe findings suggest that given the complex setting of being encountered with multiple cultural ramifications, MCS of Delta Lanka encompasses compulsory elements instigated by the parent company, and non-compulsory elements as attuned to the realities of the local culture of the operating company. The authors show how imposed practices in the institutional environment by the parent company (homogeneity) interact with agentic aspects of actors in the operating company giving rise to practice variation (heterogeneity) in the adoption of controls at the local level.Practical implicationsThe paper offers insights on how practicing managers in operating companies of MNCs could formulate control systems by striking a balance between multiple cultural considerations (of the parent and operating company). This would be a lesson for managers of other firms (especially MNCs).Originality/valueBy bringing together multitude of cultural dimensions relating to the parent company and operating company into a single study in the area of management control, this paper adds to the burgeoning literature on the interplay between external institutions, agency of actors, culture and MCS. It also contributes to the on-going debate on MCS research taking a post-Hofstede orientation while extending the use of institutional theory in management accounting research in MNCs.