bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Film Thickness of Restorative Composites Considered for Thermo‐Modified Cementation
Authors: Magne Pascal , Alawie Sam , Magne Michel , Carvalho Marco , Milani Taban 
Published: November 2024

ABSTRACTObjectiveThis study proposes an updated method for the film thickness of 21 resin composites used as cements.Materials and MethodsA load of 30 N was subjected to two glass plates stacked on a heated base to simulate clinically relevant pressure and temperature during the seating of inlays/onlays/veneers. The axial position of the actuator was recorded before and after placing 22.15 mm3 of resin composite between the glass slides. The difference between the two measurements was calculated for each specimen. A total of 18 condensable restoratives, 1 injectable restorative, and 2 resin cements were tested, 5 specimens each (n = 5, N = 105). One‐way ANOVA was performed for both variables and Games‐Howell post hoc test was used for pairwise comparisons.ResultsThe film thickness range was 6–200 μm, with the lowest values for restorative composites (AP‐X, Z250, and Herculite XRV Incisal LT with 6–8 μm), followed by Gradia Direct (25 μm) and flowable/injectable composite resins, including designated cements (15–27 μm). Inspiro, Ultradent Transcend Universal, and ENA Hri dentin stood below 50 μm (range 28–49 μm). The other materials (range 81–200 μm) cannot be recommended for thermo‐modified cementation.ConclusionsThe initial viscosity of restorative composites is not an indication of the film thickness when used for thermo‐modified cementation. There is a wide choice of appropriate materials available on the market.Clinical SignificanceSome restorative composites are able to generate very thin films and can be used as cement with numerous advantages when compared to designated flowable or dual‐cure cements.
A Generalized Endogenous Grid Method for Default Risk Models
Authors: JANG YOUNGSOO , LEE SOYOUNG 
Published: November 2024

AbstractWe extend the endogenous grid method to default risk models, which is faster and more accurate than grid search. Our method is 4 to 27 times faster and provides a more accurate bond price function, resulting in substantial differences in the predictions of the canonical sovereign debt model. When applied to Arellano's (2008) model, our approach predicts a standard deviation of the interest rate spread one‐third lower and defaults 3 to 5 times less frequently than does the conventional approach. Finally, we demonstrate that our method is applicable to a broad class of default risk models by characterizing sufficient conditions.
Asset Exemption in Bankruptcy, Access to and Cost of Credit
Authors: ARCA PASQUALINA , ATZENI GIANFRANCO , DEIDDA LUCA G. 
Published: November 2024

AbstractUnder the U.S. personal bankruptcy law, exempt assets are not liquidated following bankruptcy. Entrepreneurs can undo such a protection by posting collateral. We provide a complete characterization of the interplay between asset exemption from liquidation upon default and adverse selection in a competitive credit market. Severe adverse selection induces separation, with safer entrepreneurs choosing loan contracts characterized by high collateral requirements, lower cost of credit, and credit rationing for wealth‐constraints applicants. Irrespective of adverse selection, poor safe entrepreneurs pool as they face too much rationing, otherwise. Higher exemption makes collateral more informative. Evidence from the Survey of Small Business Finances survey supports our theory.
The Impact of Regulatory Stress Tests on Banks' Portfolio Similarity and Implications for Systemic Risk
Authors: BRÄUNING FALK , FILLAT JOSÉ L. 
Published: November 2024

AbstractPortfolio similarity among the largest U.S. banks has increased since stress testing began in 2012. Using aggregate and detailed loan‐level data, we find that, as a result of stress testing, banks rebalance their portfolio toward similarly diversified portfolios, leading to higher concentration in the aggregate banking system and raising financial stability concerns as systemic risk contributions increase. The rebalancing is driven by a supply contraction in loans that cause larger losses under stress testing, especially by banks with high capital losses in past stress tests. This rebalancing holds conditional on assets that have identical contributions to regulatory capital requirements.
Screening for Frailty According to Rural and Suburban Health Areas in the Context of Adapted Integrated Care for Older People Approach: The FRAGING Study
Authors: Chambonnière Camille , Blanquet Marie , Delorme Cassandra , Flory Laurie , Metz Lore , Duclos Martine 
Published: November 2024

ABSTRACTBackgroundThe integrated care for older people (ICOPE) program, developed by the World Health Organization, serves as a public health initiative to maintain older adults’ functional abilities and promote healthier aging. Here, we adapted the ICOPE approach to assess overall prevalence of frailty in rural and semi‐urban areas. We also investigated health‐related quality of life and physical activity and sedentary behavior in older people.MethodsThe FRAGING multicenter cohort study was performed on screening days dedicated to older adults (≥65 years) without chronic disease in a rural area (RU) and in a semi‐urban area (SU).ResultsThe study included a total of 105 participants: 98.4% of participants were frail, with a mean of 4.3 [SD: 2.5] frailties per participant. RU participants had higher number of frailties (p = 0.02) and a higher percentage of frail participants in the dimensions of health‐related quality of life (p < 0.0001), socioeconomical level (p = 0.008), colorectal cancer screening (p = 0.022), and tetanus booster doses (p = 0.008). Globally, women were less sedentary than men (p = 0.02) and engaged more in low physical activity (LPA) than men (p = 0.01). RU participants engaged more in LPA than SU participants (p = 0.03).ConclusionsThe prevalence of frailty is alarmingly underestimated in older adults without chronic disease. This study demonstrated the need to propose appropriate, validated screening tests that consider territorial issues and organization of care delivery. The ICOPE framework serves as a good startpoint for reorganizing person‐centered healthcare pathways.
Slowing Down or Adapting to Technological Progress? Robot Replacement Risks and Policy Preferences
Authors: Fan Ziteng , Ning Jing , He Alex Jingwei 
Published: November 2024

ABSTRACTThe relationship between automation risk and policy preferences is receiving increasing scholarly attention, but the discussion has yielded mixed and even contradicting results. This study aims to reconcile the results and contribute to the literature by exploring the specific conditions under which citizens prefer government interventions to reduce automation risk and their preferences for specific policy options. Using a survey experimental design in the case of robot installation in China, we find that individuals prefer government interventions that address automation risk in dangerous workplaces vs. those in regular workplaces. Individuals appear to prefer social investment policies such as training programs rather than taxation (e.g., robot tax), regulatory policies (e.g., robot quota), and compensatory policies (e.g., unemployment benefits) when exposed to such risks. We explain that citizens support the government in reducing robot replacement risk only when they perceive the beneficiary groups to be deserving of social protection and that the adopted policies can balance technological progress and unemployment risks.
Geometric algebra for multibody dynamics. Part II: Applications
Authors: Bauchau Olivier 
Published: November 2024

Abstract
In a companion paper, the fundamentals of vector space geometric algebra and plane-based geometric algebra were developed. Plane-based geometric algebra was found to be well suited for describing the kinematics of multibody dynamics: all required operations are performed using algebraic manipulations only and singularities are avoided altogether. The present paper presents applications of plane-based geometric algebra to problems of rigid and flexible multibody dynamics. The formulation of rigid bodies, flexible joints, geometrically exact beams, and lower-pair joints are developed.
Low-energy incomplete fusion: A systematic study of entrance channel parameters
Authors: Jashwal Anuj Kumar , Agarwal Avinash , Kumar Munish , Vardhan Harsh , Khan Mohd. Faizan , Rizvi I. A. , Chaubey A. K. , Kumar K. , Dutt S. 
Published: November 2024

Research into heavy-ion fusion, a key area of modern nuclear reaction physics, has flourished in recent decades pursuant to developments in accelerator technology. The primary goal of studying heavy-ion reactions is to gain knowledge about the underlying processes and how they are affected by entrance channel parameters, such as beam energy, angular momentum and mass asymmetry. The fusion mechanism of non-[Formula: see text]-cluster projectiles, such [Formula: see text]N and [Formula: see text]F, has been studied in the low-energy zone. It has been challenging to analyze the contributing degrees of freedom in such reactions due to the absence of experimental data. The present study reports the measurement of residual cross-sections from the [Formula: see text]F induced reaction on [Formula: see text]Nb within the energy range of 3–6 MeV/A. The stack foil activation technique followed by offline [Formula: see text] spectroscopy was employed to measure the cross-sections of residues populated in the reaction. The experimental data were compared with theoretical predictions from statistical model code PACE4 to probe the underlying reaction dynamics. The imitation of xn and pxn channel data grossly by model code suggests the production of residues via the complete fusion (CF) mode, while the enhancement observation in [Formula: see text]-channel cross-sections hints at the signatures of incomplete fusion (ICF) in addition to the dominant CF. Thus, the ICF strength fraction ([Formula: see text]) was calculated. Moreover, the estimated incomplete fusion fraction has been used to study the effect of several entrance channel parameters on incomplete fusion reaction dynamics. The present analysis shows the presence of strong clustering in the [Formula: see text]F projectile as [Formula: see text] and [Formula: see text]N.
Cluster of Speaking‐Up Behavior in Clinical Nurses and Its Association With Nursing Organizational Culture, Teamwork, and Working Condition: A Cross‐Sectional Study
Authors: Lee Eunhee , Kwon Hyunjeong 
Published: November 2024

Introduction: Nurses, as frontline healthcare professionals, play a crucial role in ensuring patient safety, making their ability to speak up imperative. However, there are limited studies categorizing nurses based on their speaking‐up behaviors and comparing their organizational characteristics. This study aimed to identify patterns of nurses’ speaking‐up behaviors and examine differences in organizational cultures, teamwork climates, and working conditions according to these patterns.Methods: A cross‐sectional survey was conducted, involving 597 nurses directly participating in nursing care in Korean hospitals. The Speaking Up about Patient Safety Questionnaire (SUPS‐Q), Nursing Organizational Culture Questionnaire, and Safety Attitude Questionnaire‐Korean version (SAQ‐K) were employed to measure nurses’ speaking‐up‐related behaviors, organizational culture, teamwork climate, and working conditions. Cluster analysis was used to identify clusters of nurses based on their speaking‐up‐related behavior. Differences in nursing organizational culture, teamwork climate, and working conditions among clusters were analyzed using one‐way analyses of variance.Results: Three clusters of nurses were identified based on their speaking‐up‐related behaviors. Cluster 1 (35%) showed high perceived concerns, moderate withholding, and speaking up, while Cluster 2 (37%) had moderate concerns, low withholding, and high speaking up. Cluster 3 (28%) had moderate concerns but low withholding and speaking up. Clinical experience significantly differed among clusters, with less experienced nurses predominantly in Cluster 1. Cluster 2 had the most collaborative culture, best teamwork climate, and working conditions.Conclusion: Ensuring patient safety requires nurses to speak up about patient safety concerns. Creating safe working environments and fostering an organizational culture that prioritizes patient safety are essential steps in promoting nurses’ willingness to speak up about patient safety.
Identification of a Novel Mesenchymal Stem Cell–Related Signature for Predicting the Prognosis and Therapeutic Responses of Bladder Cancer
Authors: Yang Enguang , Ji Luhua , Zhang Xinyu , Jing Suoshi , Li Pan , Wang Hanzhang , Zhang Luyang , Zhang Yuanfeng , Yang Li , Tian Junqiang , Wang Zhiping 
Published: November 2024

Background: Mesenchymal stem cells (MSCs) have been identified to have a unique migratory pattern toward tumor sites across diverse cancer types, playing a crucial role in cancer progression, treatment resistance, and immunosuppression. This study aims to formulate a prognostic model focused on MSC‐associated markers to efficiently predict the clinical outcomes and responses to therapy in individuals with bladder cancer (BC).Methods: Clinical and transcriptome profiling data were extracted from The Cancer Genome Atlas Urothelial Bladder Carcinoma (TCGA‐BLCA) and GSE31684 databases. Systematic quantification of MSC prevalences and stromal indices was undertaken, culminating in the discernment of genes correlated with stromal MSCs following a thorough application of weighted gene coexpression network analysis techniques. Subsequently, an exhaustive risk signature pertinent to MSC was formulated by amalgamating methods from univariate and Least Absolute Shrinkage and Selection Operator (LASSO) Cox regression models. Drugs targeting genes associated with MSCs were screened using molecular docking.Results: The prognostic model for MSC incorporated five critical genes: ZNF165, matrix remodeling‐associated 7 (MXRA7), CEMIP, ADP‐ribosylation factor‐like 4C (ARL4C), and cerebral endothelial cell adhesion molecule (CERCAM). In the case of BC patients, stratification was performed into discrete risk categories, utilizing the median MSC risk score as a criterion. It was striking that those classified within the high‐MSC‐risk bracket demonstrated correlations with unfavorable prognostic implications. Enhanced responsiveness to immunotherapy in low‐MSC‐risk patients was delineated compared to their high‐MSC‐risk counterparts. A heightened receptivity was noted toward particular chemotherapy drugs, encompassing gemcitabine, vincristine, paclitaxel, gefitinib, and sorafenib, within this high‐risk group. Conversely, a superior reaction to cisplatin was distinctly evident among those marked by low MSC scores. The results of molecular docking demonstrated that kaempferol exhibited favorable docking with ZNF165, quercetin exhibited favorable docking with MXRA7, mairin exhibited favorable docking with CEMIP, and limonin diosphenol exhibited favorable docking with ARL4C.Conclusions: The five‐gene MSC prognostic model demonstrates substantial efficacy in prognosticating clinical outcomes and gauging responsiveness to chemotherapy and immunotherapy regimens. The genes ZNF165, MXRA7, CEMIP, ARL4C, and CERCAM are underscored as promising candidates warranting further exploration for anti‐MSC therapeutic strategies, thereby offering novel insights for personalized treatment approaches in BC.
Abstract A022: Novel technology affords real-time PCR the sensitivity required for minimal residual disease monitoring
Authors: Stischer Mary , Allen Nick , Barbari Stephanie , Kane Sarah 
Published: November 2024

Abstract
Monitoring minimal residual disease (MRD) provides invaluable information for disease progression and therapeutic decision making. However, there are many challenges to reliably detect key mutations or biomarkers, such as the accessibility, turnaround time, and sensitivity of current methods. High sensitivity is crucial due to the limited DNA available in certain sample types such as liquid biopsy. Next generation sequencing (NGS) is capable of highly sensitive detection but is dependent on high sample input and read depth, which is not always feasible due to the variable nature of circulating tumor DNA (ctDNA) in blood or plasma. In addition, NGS is not an economical nor rapid option for recurrent longitudinal monitoring. Digital PCR (dPCR) offers the sensitivity required for MRD monitoring but has yet to be widely adopted for this application. While real-time and qPCR are commonly used in oncology research, RT-PCR does not have the sensitivity required for early detection of key MRD mutations. Here, we present novel patent-pending technology that enhances the sensitivity of RT-PCR, allowing this common platform to be used to reliably detect low abundant mutations. We performed comparisons between GT Molecular’s patent-pending technology paired with RT-PCR and commercially available research use only dPCR and NGS assays to assess the sensitivity this new technology provides for RT-PCR. Cell-free DNA (cfDNA) was extracted from real patient or contrived plasma samples using the QIAamp Circulating Nucleic Acid Kit and analyzed using RT-PCR and dPCR assays targeting KRAS or ESR1 mutations. Samples with KRAS or ESR1 mutations were tested at variant allele frequencies (VAFs) varying between 1%-0.01% to evaluate the ability of GT Molecular’s new technology to detect low abundant mutations using RT-PCR. KRAS and ESR1 mutations were reliably detected with RT-PCR at VAFs as low as 0.01%, demonstrating sensitivity comparable to dPCR. Samples demonstrating positivity for KRAS or ESR1 mutations via dPCR were also positive via RT-PCR. With this patent-pending technology, RT-PCR is now capable of achieving the sensitivity required for MRD monitoring, providing critical information from liquid biopsy samples at a fraction of the cost.
Citation Format: Mary Stischer, Nick Allen, Stephanie Barbari, Sarah Kane. Novel technology affords real-time PCR the sensitivity required for minimal residual disease monitoring [abstract]. In: Proceedings of the AACR Special Conference: Liquid Biopsy: From Discovery to Clinical Implementation; 2024 Nov 13-16; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2024;30(21_Suppl):Abstract nr A022.
As Décimas Urbanas e novas abordagens sobre a história das cidades oitocentistas
Authors: Moura Nádia Mendes de , Borsoi Diogo Fonseca 
Published: November 2024

The Décima Urbana tax was established in 1808, in the context of the Portuguese Crown's arrival in Brazil and consisted of charging 10% of the value of urban properties "in conditions to be inhabited", with the exception of properties belonging to Houses of Mercy. In recent years, researchers have advanced in documentary research, exploring new typologies beyond laws and royal directives. The surviving documents from this collection have become valuable sources for research on urban and city history, as they provide a material 'snapshot' of the city during a specific period, as well as insights into urban property ownership. This article aims, first, to present the source by exploring the context of its creation, the bureaucratic routine involved, the agents responsible for the collection, as well as its inaccuracies and limitations. It then conducts a literature review of research that has used this documentation, aiming to map approaches and methods of work. Finally, it aims to point out some potentialties of the document in other areas of work.
Effects of different water temperatures on the ovarian development and biochemical composition of Portunus trituberculatus after mating (Decapoda, Portunidae)
Authors: Wan Litao , Wu Yiting , He Jie , Zhang Dongxu , Shi Huilai , Zhang Tao 
Published: November 2024

Abstract
This study investigated the effects of different water temperatures (20, 23, 26 and 29°C) on the ovarian development and biochemical composition of Portunus trituberculatus (a swimming crab) after mating. The results showed that the higher the water temperature was, the faster the ovarian development, especially the GSI in the 29°C group was significantly higher than that in the 20°C and 23°C groups (). The hepatosomatic index (HSI) decreased with increasing water temperature, but there was no significant difference between the groups at different water temperatures (). The muscle yield (MY) was basically maintained at approximately 34%. The condition factor (CF) of the crab reached 0.62 in the 29°C group, which was significantly higher than that in the 20°C and 23°C groups (). Histological observation revealed that the number of lipid droplets and the degree of homogenization of yolk granules in ovarian oocytes gradually increased with the increase of the water temperature. From the perspective of conventional biochemical composition, the moisture and crude protein contents in muscle and the crude fat content in hepatopancreas did not change much among the groups, but the crude protein content in the ovary of the 29°C group was as high as 24.65%, which was significantly higher than that in the other three groups (). In terms of fatty acid composition, there was little difference in the fatty acid content in the ovaries of the different water temperature groups. The contents of C22 : 2n6 and C18 : 3n3 in polyunsaturated fatty acids were significantly higher in the 29°C group than in the other three groups (). In the hepatopancreas, the contents of C22 : 5n3 (DPA) and C22 : 6n3 (DHA) in the 20°C group were the lowest, 0.07% and 0.15%, respectively, which were significantly lower values than in the 29°C group (). The change of amino acid content is mainly reflected in ovarian tissues, showing a gradual upward trend as a whole. Furthermore, the essential amino acid score (EAAS) and average score of the two tissues in the 20°C and 23°C groups were relatively close, and both reached the highest score in the 29°C group. Overall, with increasing water temperature, the rate of ovarian development significantly accelerated, and the nutritional quality of the tissues improved in these swimming crabs.
Insights into brachyuran crab phylogeny: exploring the mitochondrial genome of Arcotheres sinensis (Brachyura, Pinnotheridae)
Authors: Liang Xinjie , Duan Xinbing , Li Jiji , Ye Yingying 
Published: November 2024

Abstract
The phylogeny of species of Brachyura, particularly within the family Pinnotheridae, remains incompletely understood. To enhance the taxonomy and systematics of the Pinnotheridae, we conducted a comprehensive study aimed at elucidating the phylogenetic position of Arcotheres sinensis. Consequently, we sequenced and annotated the complete mitochondrial genome of A. sinensis, The results revealed that the circular mitogenome of A. sinensis spans 16 520 bp in length. Distinct from typical mitogenomes, A. sinensis contains 13 protein-coding genes (PCGs), 2 ribosomal RNA genes and 23 transfer RNA genes. The A + T content of the A. sinensis mitogenome is 71.63%, with both AT-skew and GC-skew being negative. The lengths of the 23 tRNA genes range from 62 to 72 bp. All tRNA genes exhibit typical cloverleaf structures, except for the trnS1 gene, which lacks the dihydrouridine (DHU) arm. Selection pressure analysis revealed that all PCGs are under evolutionary selection, with cox1 experiencing strongest purifying selection and atp8 undergoing weakest purifying selection. Compared to ancestral Brachyura, the gene order of A. sinensis has been rearranged from R-N--E to -E-N-R and the sequence I-Q-M has transitioned to Q-I-M. Phylogenetic analysis unequivocally positions A. sinensis within the taxonomic framework of the family Pinnotheridae, highlighting its intimate phylogenetic relationship with congeners within the same familial clade, notably Arcotheres purpureus and Pinnotheres excussus. These findings contribute to a better understanding of the status and evolutionary history of Pinnotheridae species.