bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive model for hardware calibration to transmit real‐time applications in VoIP networks
Authors: Gupta Nishant , Mahajan Nitish , Kaushal Sakshi , Kumar Naresh , Kumar Harish , Sangaiah Arun Kumar 
Published: February 2019

SummaryVoice over Internet Protocol (VoIP) carries and transforms voice over the IP networks. The principles of VoIP calls are similar to traditional telephony that involves signalling, channel‐setup, digitization, and encoding of speech signal, but it transmits data over a packet‐switched network instead of circuit‐switched network. Factors which determine VoIP Quality of Service (QoS) include the choice of codec, packet loss, delay, jitter, and optimal hardware selection to handle different services. Hardware Calibration is a mechanism used for selecting an appropriate hardware for call manager to process and transmit different applications in real time. The widespread use of VoIP services in formal and informal sector produces a significant amount of data with variety of dimensions. This data can be used as leverage to analyze the system and predict various factors boosting the performance and cost effectiveness of the system. This paper proposes a predictive model that selects the best suitable hardware to handle particular offered load, which can support desired numbers of concurrent calls from wide array of processors available in the market today. This model would help the VoIP service providers in providing efficient services with QoS for different VoIP services like voice, data, video, chat, etc. This paper attempts to train and evaluate a model using various system parameters and system benchmark is predicted on an absolute scale. The results effectively demonstrate the selection of best call manager to handle offered load and hence provides QoS in overall network performance.
Efficient hash function–based duplication detection algorithm for data Deduplication deduction and reduction
Authors: Periasamy J.K. , Latha B. 
Published: February 2019

SummaryData Deduplication is the foremost technique used for data compression by removing redundant data. It is broadly utilized for cloud storage server, which reduces the un‐utilized memory space and optimized bandwidth. The confidentiality of sensitive information maintains during Deduplication detection. The Efficient Hash Function–based Duplication Detection (EHFDD) algorithm is proposed to encrypt the content before outsourcing in cloud environment. This paper is an attempt to enhance the data security and notify the issues of approved data Deduplication detections. Furthermore, it also presents several novel Deduplication improvisations for helping certified duplicate verification in hybrid cloud. The EHFDD method enables duplicate detection scheme with minimal overhead compared to existing functions. Based on experimental evaluations, proposed EHFDD algorithm reduces the average delay in 28.7 milliseconds, memory utilization in 8%, computation time in 457 milliseconds, communications overhead in 900 milliseconds, and improves the success rate in 3.13%.
New Kids in Lactide Polymerization: Highly Active and Robust Iron Guanidine Complexes as Superior Catalysts
Authors: Rittinghaus Ruth D. , Schäfer Pascal M. , Albrecht Pascal , Conrads Christian , Hoffmann Alexander , Ksiazkiewicz Agnieszka N. , Bienemann Olga , Pich Andrij , Herres‐Pawlis Sonja 
Published: February 2019

AbstractPolylactide is a biodegradable versatile material based on annually renewable resources and thus CO2‐neutral in its lifecycle. Until now, tin(II)octanoate [Sn(Oct2)] was used as catalyst for the industrial ring‐opening polymerization of lactide in spite of its cytotoxicity. On the way towards a sustainable catalyst, three iron(II) hybrid guanidine complexes were investigated concerning their molecular structure and applied to the ring‐opening polymerization of lactide. The complexes could polymerize unpurified technical‐grade rac‐lactide as well as recrystallized l‐lactide to long‐chain polylactide in bulk with monomer/initiator ratios of more than 5000:1 in a controlled manner following the coordination–insertion mechanism. For the first time, a biocompatible complex has surpassed Sn(Oct)2 in its polymerization activity under industrially relevant conditions.
Deconstructing the policyscape for reducing deforestation in the Eastern Amazon: Practical insights for a landscape approach
Authors: Gebara Maria Fernanda , Sills Erin , May Peter , Forsyth Tim 
Published: February 2019

AbstractIn international debates on climate change mitigation and forests, there is increased recognition of the importance of a landscape approach to effectively address tropical deforestation. Such an approach, although increasingly promoted, remains only loosely defined and requires further development in order to effectively integrate different interventions at landscape level. In particular, it is important to understand the possible interactions between different landscape interventions at local level—where they are intended to have effect—and the challenges associated with them. Inspired by the complexity of policy mix analysis, this article seeks to shed light on these interactions by analysing how different policies and measures for reducing deforestation and degradation have played out in a jurisdiction with wide‐ranging actors and interventions aimed at shaping their behaviour. Focusing on smallholders, we examine the Sustainable Landscapes Pilot Programme in São Félix do Xingu, looking at how different policies interact—categorising interactions as “complementary,” “mutually reinforcing” (synergistic), “in conflict,” “interdependent,” and/or “redundant”—and explain how proponents of this pilot programme seek to integrate them. Most analysis is based on primary data collected through quantitative (i.e., random stratified sampling and surveys) and qualitative (i.e., observation and focus groups) methods. The São Félix do Xingu case shows that understanding effects of different policies and measures on people's behaviour requires a deeper look at local perceptions and reactions to such policies and measures, something most studies on the topic have overlooked. Ultimately, the heterogeneity and complexity of social practices that permeate landscapes must be recognised in order to integrate diverse measures to reduce deforestation.
Public trust thinking and public ownership of wildlife in Italy and the United States
Authors: Giacomelli Stefano , Hare Darragh , Gibbert Michael , Blossey Bernd 
Published: February 2019

AbstractWildlife laws codify normative aspirations to conserve species. However, species continue to decline or disappear, highlighting a disconnect between normative aspirations and conservation outcomes. Public trust thinking (PTT) is a philosophical approach to natural resources, including wildlife, characterized by commitments to public control, broad public interests, and conservation for future generations. Elements of PTT feature in natural resource governance traditions across cultures and over time, notably in the common‐law public trust doctrine (PTD). We ask whether PTT's foundational principles inform public wildlife governance in Italy, a civil law country where wildlife is publicly owned but PTD does not exist. We identify all five foundational principles of PTT in elements of Italian law and policy and compare them with examples from the United States, where PTD for wildlife is more firmly established. We argue that a de facto public trust exists in Italian legal and policy aspirations, but meeting these aspirations is inhibited by absence of clear legal responsibilities and constructive, inclusive public engagement processes. By establishing that similar aspirations exist in both countries despite differences in legal histories and institutional architectures, we support claims that functional equivalents of PTD exist in civil law traditions and lend weight to recent proposals to use PTT to guide creative wildlife governance reform outside of common‐law systems. Specifying precise responsibilities for public wildlife administrators across levels of governance will be essential to connect normative aspirations with conservation outcomes.
Addressing the gap between participatory ideals and the reality of environmental management: The case of the cormorant population in Finland
Authors: Nordberg Kenneth , Salmi Pekka 
Published: February 2019

AbstractEnvironmental management, similar to public management generally, is increasingly challenged by an ever more complex society. Generally, in scientific literature, participatory features are presented as solutions for adapting centrally steered management to local circumstances and for mitigating conflicts. This article argues that local realities and transformations are easily neglected in environmental management due to unsuccessful implementation of its own participatory ideals. By studying the management of cormorant–human conflicts in Finland, the article identifies critical features that can be implemented to overcome the gap between participatory ideals and the reality of environmental management. By interviewing locals and civil servants and by directing questionnaires to fishers, the article presents how management and science look for dependencies between cormorants, fish stocks, and water nutrition, although fishers and locals are primarily concerned with the combination of seal‐ and cormorant‐induced damages, the changed behaviour of fish, and reduced recreational possibilities. Narrow scientific approaches and the national interpretation of the EU Birds directive thereby impede the management system from perceiving the complete local impact of a growing cormorant population. This article identifies obstacles hindering a balanced environmental management policy and concludes that there is a need to reinforce (a) social scientific approaches; (b) vertical negotiations at the local, national, and supranational level; and (c) the training of civil servants as facilitators of communication.
An Enantiopure Cyclometallated Iridium Complex Displaying Long‐Lived Phosphorescence both in Solution and in the Solid State
Authors: Macé Aurélie , Hellou Nora , Hammoud Joanna , Martin Clothilde , Gauthier Etienne S. , Favereau Ludovic , Roisnel Thierry , Caytan Elsa , Nasser Ghassan , Vanthuyne Nicolas , Williams J. A. Gareth , Berrée Fabienne , Carboni Bertrand , Crassous Jeanne 
Published: February 2019

AbstractA new enantiopure cyclometallated iridium complex bearing a [4]helicenic
‐coordinating and two
‐coordinating dfppy (2‐(2,4‐difluorophenyl)‐pyridyl) ligands was prepared. This complex displayed long‐lived phosphorescence both in solution and in the solid state. Its chiroptical properties, namely electronic circular dichroism and circularly polarized luminescence, were also examined. Comparison with former chiral complexes enabled assignment of the ΔIr‐(−) and ΛIr‐(+) absolute configurations.
Novel numerical solutions of nonlinear heat transfer problems using the linear barycentric rational interpolation
Authors: Torkaman Soraya , Loghmani Ghasem B. , Heydari Mohammad , Rashidi Mohammad Mehdi 
Published: February 2019

AbstractIn this investigation, a numerical technique to obtain the approximate solutions of four well‐known nonlinear differential equations in the area of heat transfer is presented. This method is based on the operational matrix of derivative of linear barycentric rational interpolation. The main advantages of this approach are that it uses the Floater‐Hormann weights, which are very efficient in practice, and reduces the governing differential equation to a system of algebraic equations. The results are compared with the obtained numerical results of the fourth‐order Runge‐Kutta method along with the shooting method and some of the previously existing methods. The acquired results reveal that the derivative operational matrix method with barycentric rational basis functions is very efficient and can be implemented easily and fast.
Comparative evaluation of the polynomial and spline fitting methods for the B0 correction of CEST MRI data acquired from human brains
Authors: Yoo Chang Hyun , Oh Janghoon , Park Soonchan , Ryu Chang‐Woo , Kwon Young Kyun , Jahng Geon‐Ho 
Published: February 2019

AbstractTo compare the magnetization transfer ratio asymmetry (MTRasym) values calculated with polynomial and spline fitting methods for B0 correction of the full Z‐spectrum images, full Z‐spectrum data was obtained from 12 elderly healthy subjects by using a 3D segmented EPI sequence, as well as from 17 other subjects by using a 3D GRASE sequence with two different 3 T MRI systems. The full Z‐spectra were analyzed to map MTRasym with three different fitting methods, namely the 10th and 14th polynomial and spline methods, for B0 correction. The MTRasym values for each offset frequency were compared among the three fitting methods. For the 3D segmented EPI sequence, the MTRasym values significantly differed among the three fitting methods at 0.86, 2.14, 3.00, and 3.43 ppm offset frequencies. For the 3D GRASE sequence, the MTRasym values obtained by 14th polynomial and spline fitting methods significantly differed at arbitrary offset frequencies. The MTRasym values are sensitive to the fitting methods of B0 correction and to the type of acquisition sequence for the full Z‐spectrum. Therefore, an appropriate fitting method should be used to analyze the full Z‐spectrum obtained from the brain.
The effects of type I collagen on bone defects and gene expression changes for osteogenesis: In a rat model
Authors: Yiğiter Özgür , Yorukoglu Ali Cagdas , Şentürk Nilay , Dodurga Yavuz , Demirkan Ahmet Fahir 
Published: February 2019

AbstractThe aim of this study is to investigate the effects of type I collagen on bone defects and on genes specifically for osteogenesis in a rat model. Two millimeter drill hole bone defect was created in the femur of rats. In the experimental group, type I collagen was applied in bone defects whereas in control group defects were left empty. Inflammation, development of connective tissue, osteogenesis, and foreign body reaction parameters evaluated with histologically and genes evaluated by blood samples. In the experimental group, the histopathologically significant change was found in favor of bone healing only at the first week. A significant increase was found in genetic expressions of BMP‐1, 2, 3, 4, 5, 6, 7, TGF‐βRII, Smad‐1, IL‐6, BMPR‐IA, BMPR‐IB, Eng, BMPR‐II, c‐fos, Cdkn1a, Chrd, Gdf‐5, Id‐1, PDGF‐β, IGF‐1, Serpine‐1, and TGF‐βRI at the first hour. At the first, third, and sixth week, no significant increase was found in any of the gene expressions. Type I collagen is found to be effective in favor of bone healing through increased inflammatory cytokines and expression of BMP genes in the early stages of fracture healing.
Network pharmacology‐based research on the active component and mechanism of the antihepatoma effect of Rubia cordifolia L.
Authors: Xiong Yiyi , Yang Yanfang , Xiong Weichen , Yao Yunfeng , Wu Hezhen , Zhang Meide 
Published: February 2019

AbstractRubia cordifolia L. is widely used in Asia and its antihepatoma effect has been proved by in vitro and in vivo experiments. However, there are few studies on its specific mechanism. In the present study, the network pharmacology method was used to construct the component/target/pathway molecular regulatory network for the antihepatoma effect of
Rubia cordifolia L. to explore the effective components of
Rubia cordifolia L. and its potential mechanism. The chemical components of
Rubia cordifolia L. were identified through literature and databases, and the components were evaluated and screened by drug likeness and pharmacokinetic characteristics (ADMET). The targets of active components were predicted according to the reverse pharmacophore matching model. The hepatic carcinoma‐related genes were found in databases, and antihepatoma‐related gene targets were selected through comparison. The functions of target genes and related pathways were analyzed and screened using the Database for Annotation, Visualization and Integrated Discovery, and the component/target/pathways network of antihepatoma effect of
Rubia cordifolia L. was constructed using Cytoscape software. Finally, 16 active compounds were screened from
Rubia cordifolia L., and 39 gene targets, including AKT1, mitogen‐activated protein kinase 1, and epidermal growth factor receptor, were involved.
Rubia cordifolia L. also affected the hepatitis B, phosphoinositide‐3‐kinase‐protein kinase B, and mitogen‐activated protein kinase signaling pathways. Many direct‐acting tumor‐related signaling pathways and indirect‐acting hepatitis pathways inhibit the generation of liver cancer. The present study provided a scientific basis for further elucidating the mechanism of
Rubia cordifolia L. against liver cancer.
Confirmatory validation of the factor structure and psychometric properties of the Difficulties in Emotion Regulation Scale‐Positive
Authors: Weiss Nicole H. , Darosh Angela G. , Contractor Ateka A. , Schick Melissa M. , Dixon‐Gordon Katherine L. 
Published: February 2019

AbstractObjectivesEmotion dysregulation is a transdiagnostic factor central to the etiology and treatment of various clinical difficulties. Yet, research in this area has focused almost exclusively on emotion dysregulation stemming from negative emotions. The current study confirmed the factor structure of the Difficulties in Emotion Regulation Scale‐Positive (DERS‐P) and further examined its reliability and validity.MethodParticipants in Study 1 were 229 college students (Mage = 19.37 years; 66.8% female; 67.2% White). Participants in Study 2 were 353 trauma‐exposed community individuals (Mage = 35.77 years; 57.8% female; 71.2% White).ResultsFindings supported the three‐factor structure of the DERS‐P. Mean levels of the DERS‐P scales demonstrated convergent and discriminant validity and differentiated individuals with (vs. without) probable posttraumatic stress disorder, depression, alcohol use, and drug use disorders.ConclusionsFindings provide additional support for the factor structure, reliability, and validity of the DERS‐P, thereby adding to its clinical utility.
Tiliroside is a new potential therapeutic drug for osteoporosis in mice
Authors: Li Kai , Xiao Yu , Wang Ziyi , Fu Fangsheng , Shao Siyuan , Song Fangming , Zhao Jinmin , Lin Xixi , Liu Qian , Xu Jiake 
Published: February 2019

AbstractOsteoporosis is a class of metabolic bone disease caused by complexed ramifications. Overactivation of osteoclasts due to a sudden decreased estrogen level plays a pivotal role for postmenopausal women suffering from osteoporosis. Therefore, inhibiting osteoclast formation and function has become a major direction for the treatment of osteoporosis. Tiliroside (Tle) is a salutary dietary glycosidic flavonoid extracted from Oriental Paperbush flower, which has been reported to have an anti‐inflammation effect. However, whether Tle affects the osteoclastogenesis and bone resorption remains unknown. Herein, we demonstrate that Tle prevents bone loss in ovariectomy in mice and inhibits osteoclast differentiation and bone resorption stimulated by receptor activator of nuclear factor‐κB ligand (RANKL) in vitro. Molecular mechanism studies reveal that Tle reduces RANKL‐induced activation of mitogen‐activated protein kinase and T‐cell nuclear factor 1 pathways, and osteoclastogenesis‐related marker gene expression, including cathepsin K (Ctsk), matrix metalloproteinase 9, tartrate‐resistant acid phosphatase (Acp5), and Atp6v0d2. Our research indicates that Tle suppresses osteoclastogenesis and bone loss by downregulating the RANKL‐mediated signaling protein activation and expression. In addition, Tle inhibits intracellular reactive oxygen species generation which is related to the formation of osteoclasts. Therefore, Tle might serve as a potential drug for osteolytic disease such as osteoporosis.
A negative feedback loop of H19/miR‐675/EGR1 is involved in diabetic nephropathy by downregulating the expression of the vitamin D receptor
Authors: Fan WenXing , Peng YunZhu , Liang Zhang , Yang YueNa , Zhang Jing 
Published: February 2019

AbstractAimWe aimed to explore the regulatory relationship among the long noncoding RNA H19, micorRNA‐675 (miR‐675), the vitamin D (VD) receptor (VDR), and the early growth response protein 1 (EGR1) in the pathogenesis of diabetic nephropathy (DN) among patients with diabetes mellitus (DM).MethodsExpression levels of H19, miR‐675, VDR, and EGR in patients or CIHP‐1/HEK 293 cells were measured via quantitative reverse‐transcription polymerase chain reaction and western blot analysis. Computational analysis and luciferase assays were performed to determine EGR1 as a target gene of miR‐675.ResultsThe relative expression of miR‐675 was higher in the presence of H19, whereas the expression of both VDR and EGR1 messenger RNA was decreased in the presence of H19 or miR‐675. However, relative expression of H19 and miR‐675 was increased, whereas VDR expression was suppressed upon the treatment of 1,25‐dihydroxyvitamin D3 or EGR1. VDR was identified as a target gene of miR‐675. The H19 promoter and EGR1 increased the luciferase activity of cells transfected with wild‐type VDR. Compared with DM patients free of DN, the levels of H19 and miR‐675 were increased in the DN(+) group, whereas the levels of VDR and EGR1 were decreased.ConclusionIn summary, the above results indicate the presence of a negative feedback loop in the pathological mechanism of DN, where H19 downregulates the expression of VDR by upregulating the expression of miR‐675, whereas reduced VDR expression subsequently reduced the expression of EGR1. Moreover, reduced EGR1 expression inhibits H19 expression, thus forming a negative feedback loop required to maintain the homeostasis of VDR and to reduce the incidence of DN.
Amino acid restriction increases β‐cell death under challenging conditions
Authors: Mateus Gonçalves Luciana , Vettorazzi Jean Franciesco , Vanzela Emerielle Cristine , Figueiredo Mariana Sarto , Batista Thiago Martins , Zoppi Claudio Cesar , Boschero Antonio Carlos , Carneiro Everardo Magalhães 
Published: February 2019

AbstractMalnutrition programs metabolism, favor dysfunction of β cells. We aimed to establish an in vitro protocol of malnutrition, assessing the effect of amino acid restriction upon the β cells. Insulin‐producing cells INS‐1E and pancreatic islets were maintained in RPMI 1640 medium containing 1× (Ctl) or 0.25× (AaR) of amino acids. We evaluated several markers of β‐cell function and viability. AaR Insulin secretion was reduced, whereas cell viability was unaltered. Calcium oscillations in response to glucose increased in AaR. AaR showed lower Ins1 RNAm, snap 25, and PKC (protein kinase C) protein content, whereas phospho‐eIF2α was increased. AaR cells exposed to nutrient or chemical challenges displayed higher apoptosis rates. We showed that amino acid restriction programmed β cell and induced functional changes. This model might be useful for the study of molecular mechanisms involved with β‐cell programming helping to establish novel therapeutic targets to prevent harmful outcomes of malnutrition.