bluuebunny/crossref_metadata_2025_split huggingface dataset:
977-P: Validation of the Noninvasive Blood Glucose Monitoring Device Nirlus
Authors: MEYHOEFER SVENJA , WILMS BRITTA , IHLING FLAVIA , WINDJÄGER ANNE , HERRMANN VERA , AUGUSTINOV ANDREJ , SCHMID SEBASTIAN M. 
Published: June 2019

Background: Since the prevalence of diabetes mellitus has dramatically increased over the last decades, reliable non-invasive techniques for blood glucose monitoring are required to overcome problems and obstacles for regularly home-based blood glucose assessment. The aim of this study was the validation of the newly developed non-invasive blood glucose system NIRLUS® (Near Infra Red Light Ultra Sound, NIRLUS Engineering AG, Lübeck, Germany) under well standardized conditions.
Methods: 17 healthy normal weight men (BMI: 22.4 ± 1.4 kg/m2) aged 18 to 45 years were enrolled in this study. During an intravenous glucose tolerance test (ivGTT), blood glucose profiles were measured simultaneously by two researchers with the NIRLUS® system (blinded for measured values) and a gold-standard laboratory reference system (reference, EKF-Diagnostics Biosen C-line, Barleben, Germany), respectively. During the course of ivGTT, blood glucose levels ranged from hyper- to mild hypoglycemia.
Results:Correlation analysis revealed a strong association between NIRLUS and reference values (r=0.934; p&lt;0.00). Subsequent Bland Altman analysis showeda symmetric distribution without blood glucose level depending deviation (r=0.047; p=0.395) and 95.5% of the NIRLUS/reference pairs were within the difference (d) of d±2SD. Error grid analysis revealed that 93.6% of NIRLUS/reference pairs are located in the area A, and 6.4% in the area B, respectively. No data were allocated in the areas C to E.
Conclusion: This proof-of-concept study clearly demonstrates accuracy of blood glucose measures obtained by NIRLUS®as compared to a gold-standard laboratory reference system. Precise non-invasive glucose monitoring by NIRLUS®is feasible and might lower the burden of glucose control in patients with diabetes.

Disclosure
S. Meyhoefer: Research Support; Spouse/Partner; NIRLUS Engineering AG. B. Wilms: Research Support; Spouse/Partner; NIRLUS Engineering AG. F. Ihling: Research Support; Spouse/Partner; NIRLUS Engineering AG. A. Windjäger: Research Support; Spouse/Partner; NIRLUS Engineering AG. V. Herrmann: Research Support; Self; NIRLUS Engineering AG. A. Augustinov: Research Support; Self; NIRLUS Engineering AG. S.M. Schmid: Research Support; Self; NIRLUS AG.

Funding
NIRLUS Engineering AG
979-P: Lower Glucose Thresholds for Hyperglycemia Alarm and Narrower Threshold Range for Hyper/Hypoglycemia Alarm on Continuous Glucose Monitoring Systems Correlate with Lower Average Glucose Levels and Longer Time-in-Range
Authors: LIN YU KUEI , HUNG MAN , SHARMA ANU , CHAN OWEN , VARNER MICHAEL , GROAT DANIELLE , DOPITA DANA , FISHER SIMON 
Published: June 2019

Average glucose levels (AG) and glucose time-in-range (TIR; 70-180 mg/dL) are important glucose control measurements for patients with type 1 diabetes (T1D). Continuous glucose monitoring (CGM) systems provide audible alarms for actual/impending hyper/hypoglycemic events; however, there are little data regarding optimal CGM alarm settings to improve these measures. A cross-sectional observational study was conducted enrolling 91 T1D active CGM users (real-time CGM use &gt;3 months and CGM usage time ≥70%). CGM alarm settings and two-week glucose data (total 28,133 hours) were analyzed. Glucose thresholds for hyperglycemia alarm and intra-threshold range (hyperglycemia minus hypoglycemia alarm thresholds) correlated positively with AG (P&lt;0.001, P=0.003) and negatively with TIR (P=0.004, P=0.039, respectively). Compared to quartiles with higher hyperglycemia alarm thresholds and higher intra-threshold ranges; quartiles with, 1) lower glucose threshold settings for hyperglycemia alarm, and 2) lower intra-threshold ranges, were associated with up to 45 mg/dL lower AG and 20% longer TIR. These data indicate the benefits of lower glucose thresholds for hyperglycemia alarm and lower intra-threshold ranges in promoting lower glucose levels and longer glucose time-in-range.

Disclosure
Y. Lin: None. M. Hung: None. A. Sharma: None. O. Chan: Research Support; Self; Zucara Therapeutics Inc. M. Varner: None. D. Groat: None. D. Dopita: None. S. Fisher: None.
98-OR: Cold-Induced Hyperphagia Requires AgRP Neuron Activation
Authors: DEEM JENNIFER D. , OGIMOTO KAYOKO , NELSON JARRELL , PHAN BAO ANH N. , VELASCO KEVIN R. , DAMIAN VINCENT , SCHWARTZ MICHAEL W. , MORTON GREGORY J. 
Published: June 2019

The adaptive response to cold exposure includes matched increases of both energy expenditure (to support thermogenesis) and energy intake, enabling core temperature to be maintained with no change of body fat stores. To investigate whether activation of agouti-related peptide (AgRP) neurons plays a role in this cold-induced hyperphagic response, we first determined whether this neuronal population is activated during cold exposure by employing AgRP-Cre/GFP marker mice and found that acute cold exposure rapidly induces cFos (a marker of neuronal activation) in these neurons. Further, relative to chow-fed controls housed at room temperature, mice subjected to chronic, mild cold exposure (14°C for 5 days) exhibited both the expected increase of food intake (28%) and a 117% increase of Agrp mRNA (p&lt;0.01 for both). Having established that AgRP neurons are activated by cold exposure, we next sought to determine whether this response is required for the associated hyperphagia. To this end, we used a DREADD-based pharmacogenetic approach using AgRP-IRES-Cre mice. Here, we found that cold-induced hyperphagia was blocked by inhibition of AgRP neurons (2h food intake upon acute housing at 14C: 0.26±0.06 g for Sal. vs. 0.10±0.04 g for CNO; p&lt;0.05). We next focused on the fidelity of this system in mice exposed to a high fat diet (HFD). We found that although HFD-fed mice exhibit intact thermogenic responses to cold and maintain normal core body temperature, they fail to increase energy intake (12.43±0.48 for 22C vs. 13.49±1.54 kcal for 14C; p=ns) and consequently experience weight loss not observed in lean, chow-fed controls (body weight change: 0.16±0.15g for chow vs. -0.49±0.23g for HFD; p=0.05). Since the absence of cold-induced hyperphagia in HFD-fed mice is accompanied by failure to increase hypothalamic Agrp mRNA (22C vs. 14C; 0.19±0.07 vs. 0.24±0.09; p=ns), these data demonstrate that 1) AgRP neuron activation is required for cold-induced hyperphagia, and 2) this response is impaired in HFD-fed mice.

Disclosure
J.D. Deem: None. K. Ogimoto: None. J. Nelson: None. B.N. Phan: None. K.R. Velasco: None. V. Damian: None. M.W. Schwartz: Consultant; Self; Novo Nordisk A/S. Research Support; Self; Novo Nordisk A/S. G.J. Morton: None.

Funding
University of Washington Diabetes Research Center
980-P: Tirzepatide, a Dual GIP and GLP-1 Receptor Agonist, Improves Markers of Beta-Cell Function and Insulin Sensitivity in Type 2 Diabetes Patients
Authors: THOMAS MELISSA K. , NIKOOIENEJAD AMIR , BRAY ROSS , CUI XUEWEI , WILSON JONATHAN M. , DUFFIN KEVIN L. , MILICEVIC ZVONKO , HAUPT AXEL , ROBINS DEBORAH A. 
Published: June 2019

Tirzepatide (TZP), a novel dual GIP and GLP-1 receptor agonist (RA), showed significantly greater glucose control and weight loss compared to the selective GLP-1 RA dulaglutide (DU) in a 26-week, randomized, double-blind Phase 2b study of type 2 diabetes patients. TZP doses tested were 1, 5, 10, and 15 mg versus placebo (PB) and DU 1.5 mg. Fasting markers of beta cell function and insulin sensitivity were analyzed by mixed model repeated measures to explore differentiated mechanisms of glucose control by TZP. Biomarkers of beta cell function were improved by TZP. Proinsulin to insulin ratios, insulin processing markers of beta cell stress, were significantly reduced by TZP 10 and 15 mg compared with PB and DU. HOMA2-B significantly increased with DU and TZP 5, 10, and 15 mg compared with PB. TZP 10 mg significantly improved insulin sensitivity as reflected by lower HOMA2-IR compared with PB and DU. TZP 10 and 15 mg significantly decreased fasting insulin compared with PB and DU, consistent with reduced insulin resistance. To evaluate weight loss contributions to improvements in insulin sensitivity with TZP, multiple linear regression with potential confounding variables age, sex, metformin use, and baseline HbA1c was conducted. An intercept-free model with weight loss as the only covariate was selected as the most significant of all possible models. Weight loss significantly (p&lt;0.004) explained 22% and 28% of variation in HOMA2-IR with TZP 15 and 10 mg, respectively, suggesting the insulin sensitizing effects of TZP are only partly attributable to weight loss. Multiple markers associated with improved insulin sensitivity were significantly increased by one or more doses of TZP compared with PB or DU, including adiponectin, IGFBP1, and IGFBP2. These data suggest that, compared with the selective GLP-1 RA dulaglutide, TZP has a greater impact on insulin sensitivity and beta cell function, resulting in improved glycemic control.

Disclosure
M.K. Thomas: Employee; Self; Eli Lilly and Company. Stock/Shareholder; Self; Eli Lilly and Company. A. Nikooienejad: Research Support; Self; Eli Lilly and Company. R. Bray: Employee; Self; Eli Lilly and Company. X. Cui: Employee; Self; Eli Lilly and Company. J.M. Wilson: Employee; Self; Eli Lilly and Company. K.L. Duffin: Employee; Self; Eli Lilly and Company. Stock/Shareholder; Self; Pfizer Inc. Z. Milicevic: Employee; Self; Eli Lilly and Company. A. Haupt: Employee; Self; Lilly Diabetes. Stock/Shareholder; Self; Lilly Diabetes. D.A. Robins: Employee; Self; Eli Lilly and Company.

Funding
Eli Lilly and Company
982-P: A Double-Blinded, Placebo Controlled, Single Ascending Dose Study for Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics after Subcutaneous Administration of Novel Long-Acting GLP-1/GIP/Glucagon Triple Agonist (HM15211) in Healthy Obese Subjects
Authors: CHOI JAE DUK , BAEK SEUNGJAE , KIM YOUNGMIN , EUN KAHEE , KWON SE CHANG , MORROW LINDA , HOMPESCH MARCUS , KANG JAHOON 
Published: June 2019

HM15211 is a novel long-acting GLP-1/GIP/Glucagon triple-receptor co-agonist with extended half-life through reduced renal clearance and through FcRn mediated vascular endothelial recycling. HM15211 has shown therapeutic potential in animal models of NASH and dyslipidemia. This study was a randomized, double-blind, placebo-controlled First-In-Human trial designed to assess safety, pharmacokinetics, and pharmacodynamics of a single subcutaneous dose of HM15211 in obese but otherwise healthy adult subjects (Total 41 subjects were randomized, the mean age was 45.7 years, 51.2% were males, and the mean BMI was 33.6 kg/m2). Subjects were randomized to one of 5 sequential ascending doses of either HM15211 or matching placebo. HM15211 was safe and well-tolerated in this population with no significant changes in heart rate, blood pressure, ECG, physical exams, and clinical laboratory tests. There was no subject who discontinued the study and there were no serious adverse events due to study medication. Compared to placebo, HM15211 suppressed corresponding endogenous incretins and reduced circulating amino acids levels in a dose dependent manner, which may be related to the mode of action of HM15211. Plasma concentration of HM15211 reached its peak level (Tmax) in 31.20 to 68.08 hours. Plasma AUC0-inf and Cmax increased in a dose-proportional manner and the terminal half-life (t1/2) was 72.09 to 142.10 hours.
In conclusion, single doses of HM15211 were well tolerated, showed PK profiles suitable for weekly administration, and initial evidence in support of the hypothesized mode of action. Clinical studies in patients with obesity with NAFLD/NASH will follow.

Disclosure
J. Choi: Employee; Self; Hanmi Pharm. Co., Ltd. S. Baek: Employee; Self; Hanmi Pharm. Co., Ltd. Y. Kim: Employee; Self; Hanmi Pharm. Co., Ltd. K. Eun: Employee; Self; Hanmi Pharm. Co., Ltd. S. Kwon: Employee; Self; Hanmi Pharm. Co., Ltd. L. Morrow: Employee; Spouse/Partner; Eli Lilly and Company. Employee; Self; ProSciento. M. Hompesch: Stock/Shareholder; Self; ProSciento. J. Kang: Employee; Self; Hanmi Pharm. Co., Ltd.
999-P: Liraglutide Treatment in Obese Diabetic Patients Modulates Gut Microbiota
Authors: MOFFA SIMONA , TESORI VALENTINA , MEZZA TERESA , ASSUNTA CEFALO CHIARA MARIA , CINTI FRANCESCA , SORICE GIAN PIO , GIACCARI ANDREA 
Published: June 2019

Recent studies in mouse models showed that Liraglutide can modulate gut microbiota suggesting this as one of the factors favoring the drug-induced weight loss. We here aimed to observationally evaluate the effect of Liraglutide on gut microbiota composition in obese diabetic humans. 11 obese diabetic subjects (age 59.6 ± 9.8; HbA1C 7.7 ± 2.7%; weight: 95.5 ± 17 kg), candidates to receive GLP-1-analogs, were included. All subjects underwent, before (B) and after 6 weeks of treatment (PT) with Liraglutide 1.2 mg, metabolic evaluation (BMI, glucose, HbA1c and LDL-cholesterol). Lactulose Breath Test (LBT) was performed to characterize gut microbiota, measuring hydrogen (H2) and methane (CH4) production; while gastric emptying time (t/2) was assessed by Octanoic Acid Breath Test. All subjects experienced a significant weight loss (BMI B: 33.9 ± 4.5 kg/m2, PT: 29.9 ± 4.2 kg/m2, p 0,001), and a significant reduction of fasting plasma glucose (FPG) (FPG B: 146.4 ± 31.5 mg/dl, PT: 118.6 ± 33.1 mg/dl p 0.02), Hb1Ac (HbA1C B: 7.7 ± 2.7%, PT: 6.2 ± 1% p 0.001) and LDL-cholesterol (LDL B: 89.5 ± 39.3 mg/dl; PT: 68.4 ± 35.9 mg/dl, p 0.006). Methane and Hydrogen production (AUC) were significantly reduced by Liraglutide in the post-treatment group (H2 B: 5093.8 ± 933 ppm, PT: 2495.5 ± 525 ppm, p 0.02; CH4 B: 1887.9 ± 286.3, PT: 1212.3 ± 334 ppm, p 0.02); moreover, the LBT revealed that Liraglutide is able to significantly slow down the Oro-cecal Transit Time (OTT). As expected, gastric emptying was significantly delayed after Liraglutide treatment (t/2 B: 72.6 ± 8.2 min, PT: 118.2 ± 25 min p 0.05). We, here, show that Liraglutide reduces intestinal gases production, which is an indirect measure of changes in gut microbiota.
In conclusion, we highlight the close relationship between glucose lowering effect of Liraglutide and the intestinal microbiota composition, suggesting that the treatment effect may be potentially mediated by changes in gut microbiota, which could in turn represent a new therapeutic target for treatment of type 2 diabetes.

Disclosure
S. Moffa: None. V. Tesori: None. T. Mezza: None. C. Cefalo: None. F. Cinti: None. G. Sorice: None. A. Giaccari: Advisory Panel; Self; Sanofi. Board Member; Self; Novo Nordisk A/S. Speaker's Bureau; Self; Amgen Inc., AstraZeneca, Merck Sharp & Dohme Corp., Sanofi.
Association of Serum Markers of Oxidative Stress With Incident Major Cardiovascular Events, Cancer Incidence, and All-Cause Mortality in Type 2 Diabetes Patients: Pooled Results From Two Cohort Studies
Authors: Xuan Yang , Gào Xin , Anusruti Ankita , Holleczek Bernd , Jansen Eugène H.J.M. , Muhlack Dana Clarissa , Brenner Hermann , Schöttker Ben 
Published: June 2019

OBJECTIVE
Oxidative stress plays an important role in the pathophysiology of type 2 diabetes mellitus (T2DM). However, associations of biomarkers of oxidative stress with diabetes complications have not yet been addressed in large cohort studies.

RESEARCH DESIGN AND METHODS
Derivatives of reactive oxygen metabolites (d-ROMs) levels, a proxy for the reactive oxygen species burden, and total thiol levels (TTLs), a proxy for the reductive capacity, were measured in 2,125 patients with T2DM from two German cohort studies of almost equal size at baseline and 3–4 years later. Multivariable adjusted Cox proportional hazards models with time-dependent modeled d-ROMs levels and TTLs were used to assess the associations with incident major cardiovascular events (MCE), cancer incidence, and all-cause mortality.

RESULTS
In total, 205, 179, and 394 MCE, cancer, and all-cause mortality cases were observed during 6–7 years of follow-up, respectively. Both oxidative stress biomarkers and the d-ROMs-to-TTL ratio were statistically significantly associated with all-cause mortality in both cohorts, and the pooled hazard ratios (HRs) and 95% CIs for top versus bottom tertiles were 2.10 (95% CI 1.43, 3.09) for d-ROMs levels, 0.59 (0.40, 0.87) for TTLs, and 2.50 (1.86, 3.36) for d-ROMs-to-TTL ratio. The d-ROMs-to-TTL ratio was also statistically significantly associated with incident MCE for top versus bottom tertile (1.65 [1.07, 2.54]), but this association did not persist after additional adjustment for chronic diseases. No associations with cancer were detected.

CONCLUSIONS
The observed strong associations of both biomarkers with mortality suggest an important contribution of an imbalanced redox system to the premature mortality of patients with diabetes.
ANALISIS PENGARUH MARKET TO BOOK VALUE, FIRM SIZE DAN PROFITABILITAS TERHADAP PENGAMBILAN KEPUTUSAN LINDUNG NILAI (Studi Kasus Pada Perusahaan Sub Sektor Otomotif Dan Komponennya Yang Terdaftar Di Bursa Efek Indonesia Pada Tahun 2014–2017)
Authors: Setiawan I Gusti Agung Ngurah Alit Pramana , Mahardika Dewa Putra Krishna 
Published: June 2019

Perusahaan di Indonesia banyak melakukan transaksi dengan perusahaan luar negeri menggunakan mata uang asing, contohnya US Dolar dengan tujuan pemenuhan kebutuhan akan persediaan, mesin, dll. Beberapa tahun belakangan nilai tukar rupiah terhadap US Dolar mengalami fluktuasi. Fluktuasi nilai tukar rupiah yang terjadi cenderung mengarahkan pada rupiah yang semakin melemah. Hal ini merupakan sebuah ancaman risiko bagi perusahaan yang melakukan transaksi dengan pihak luar negeri. Untuk meminimalisir risiko tersebut perusahaan dapat melakukan lindung nilai atau hedging. Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh Market To Book Value, Firm Size Dan Profitabilitas pada perusahaan sub sektor otomotif dan komponennya. Penelitian ini juga bertujuan untuk mengetahui bagaimana pengaruh Market To Book Value, Firm Size dan Profitabilitas baik secara simultan maupun parsial terhadap Pengambilan Keputusan Lindung Nilai Pada Perusahaan sub sektor Otomotif dan Komponennya yang terdaftar di BEI Pada tahun 2014–2017. Teknik pengambilan sampel yang digunakan pada penelitian ini adalah teknik purposive sampling yang memperoleh 12 sampel penelitian dalam kurun waktu 4 tahun sehingga di dapat 48 unit sampel perusahaan Sub sektor Otomotif dan Komponennya yang terdaftar di BEI pada tahun 2014–2017. Teknik analisis data yang digunakan adalah analisis statistic deskriptif dan regresi logistik. Berdasarkan hasil penelitian menunjukkan bahwa Market To Book Value, Firm Size dan Profitabilitas secara simultan berpengaruh terhadap Pengambilan Keputusan Lindung Nilai. Secara parsial Market To Book Value berpengaruh negatif dan tidak signifikan terhadap lindung nilai, Firm Size berpengaruh positif signifikan terhadap lindung nilai, dan Profitabilitas berpengaruh positif dan tidak signifikan terhadap lindung nilai. Dari hasil tersebut dapat disimpulkan bahwa, Market To Book Value berpengaruh negatif dan tidak signifikan karena dengan fenomena yang terjadi MTBV tidak sepenuhnya menjadi landasan perusahaan melaksanakan lindung nilai. Firm Size berpengaruh positif signifikan karena semakin besar ukuran perusahaan maka risiko yang dialami akan meningkat sehingga lindung nilai dilaksanakan. Profitabilitas berpengaruh positif dan tidak signifikan karena risiko yang dialami atas peningkatan profitabilitas dapat diminimalisir dengan lindung nilai natural sehingga tidak berpengaruh signifikan.
Service-Oriented Architecture In Automation Industries
Authors: Halili Dr.Festim , Blakaj-Gashi,Msc Elida / , Blakaj MSc, Selvije 
Published: June 2019

This paper addresses issues and difficulties in the advancement of cutting edge installed gadgets, applications and its administration that Service-Oriented Architecture (SOA) handles in Automation Industries (AI).Because of SOAs expanding knowledge and traces of the methodology received, just as the business points of interest advancement, the assembling business with SOA expresses deep complexity and yet simple usage in process of automation. The future assembling undertakings will be portrayed by as often as possible changing business sector requests, time-to-showcase weight, constantly developing new advances and, most importantly, worldwide challenge.
SOA and web innovation have evolved its route to support an unavoidably arranged world in which billions of individuals and trillions of devices and gadgets will be interconnected in different ways. As a component of this development, Internet innovation is rising as the essential bearer for interconnecting – utilized in mechanical mechanization, car hardware, building controls, home robotization, service automation, and so on.
Sobre a espessura do texto (uma leitura cadente)
Authors: Pinheiro Luciana Paiva 
Published: June 2019

O presente artigo propõe a contemplação de elementos visuais implícitos no espaço da escrita com o objetivo de provocar um adensamento da superfície do texto para além de seu sentido linguístico. De acordo com determinadas noções da Geografia Literária de Michel Collot é possível ampliar a experiência sensível da paisagem para o campo da escrita. Para tanto, o artigo apresenta um percurso conduzido pelo horizonte das linhas escritas, partindo do branco que submerge da página, passando pelo vértice do livro que nos atrai como em um vórtice, até alcançar a ultima linha do texto.
Entre os discursos poético, crítico e historiográfico artístico
Authors: Pugliese Vera 
Published: June 2019

O artigo discute como uma obra de arte, L’Altra Figura (1983) de Giulio Paolini, compreendida como discurso, pode dialogar com diferentes literaturas artísticas, diante do atual debate sobre a circunscrição da história da arte, suas práticas e metodologias. A hipótese de que o discurso teórico poderia ser crítico e poético é colocada em jogo mediante diferentes abordagens à obra de Paolini entre a crítica e a historia da arte, face à inacessibilidade do fenômeno estético e de um discurso totalizante sobre ele.
O Livro dos Regimentos dos Oficiais Mecânicos e os estudos arquitetônicos da Biblioteca Nacional de Portugal
Authors: Brandão Angela 
Published: June 2019

O Livro dos Regimentos dos Oficiais Mecânicos, manuscrito do século XVI, onde se compilaram leis consuetudinárias (que regiam os trabalhos artesanais em Portugal, desde à Idade Média), faz referência a desenhos-modelo para a realização dos exames dos ofícios. No entanto, ao observarmos o original conservado no Arquivo da Câmara de Lisboa, não localizamos quaisquer desenhos, o que nos levou a deduzir que seriam papéis avulsos. A coleção de desenhos com motivos arquitetônicos conservada na Biblioteca Nacional de Portugal não traz resposta definitiva para o problema, mas indica um caminho de reafirmação, no século XVIII, da exemplaridade das ordens clássicas.
Paris, etapa obrigatória para a glória. Os prêmios concedidos aos artistas estrangeiros nos Salões parisienses de 1802 a 1824
Authors: Lobstein Dominique , Couto Maria de Fátima Morethy 
Published: June 2019

Após a reforma de 1791, que abriu as portas do Salão a todos os artistas, os estrangeiros apresentaram-se em massa para expor. Quando um sistema de premiação foi estabelecido, no início do século seguinte, os estrangeiros se beneficiaram imediatamente. Os documentos preservados do evento permitem identificar os artistas estrangeiros premiados - sendo o primeiro o pintor espanhol José Aparicio, em 1804 - e o tipo de prêmio obtido. Segundo uma estratégia comum, os medalhistas, que vinham estudar por alguns anos na França, retornavam a seus países e corroboravam suas carreiras nesse reconhecimento oficial parisiense, situação perfeitamente ilustrada por John Constable fazendo inserir a moldagem de sua medalha de ouro do Salão 1824 na moldura de seu Carroça de Feno (Londres, National Gallery).