bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective Validation of Prehospital Acute Stroke Severity Scale to Predict Large Vessel Occlusion in Acute Stroke Patients - Single Center study in China
Authors: Si Xiaoli , Fang Yuanjian , Xia Wenqing , Chen Tianwen , Huang Huan , Liu Keqin , Jiang Lin , Yin Congguo 
Published: July 2019

Abstract
Background and Purpose

- To date, identifying emergent large vessel occlusion (ELVO) patients in the prehospital stage is important but still challenging. We aimed to retrospectively validate a simple prehospital stroke scale——Prehospital Acute Stroke Severity (PASS) scale to identify ELVO.

Methods

- We retrospectively evaluated our consecutive cohort of acute ischemic stroke (AIS) who underwent CT angiography (CTA), MR angiography (MRA) or digital subtraction angiography (DSA). PASS scale was calculated based on National Institutes of Health Stroke Scale (NIHSS) items retrospectively. The comparison of diagnostic parameters between PASS scale and NIHSS scale were performed.

Results

- Finally, a total of 605 patients were enrolled. ELVO patients with PASS≥2 had a median NIHSS score of 14. The best predictive value of PASS≥2 showed a similar predictive value compared with NIHSS≥9. Cortical symptoms such as consciousness disorder and gaze palsy were more specific indicators for ELVO than motor deficits. Consciousness disorder was more serious in posterior circulation infarct (PIC) while gaze palsy was more common in anterior circulation infarct (AIC).

Conclusions

- PASS scale had both good discrimination and calibration in our retrospective cohort. It could reflect acute stroke severity well and predict ELVO in an effective and simple way. Moreover, cortical symptoms had high specificities to predict ELVO on their own.
Fibroblast Growth factor 23 and α-Klotho protein are associated with adverse clinical outcomes in non dialysis chronic kidney disease stage 1-5 patients
Authors: Manou Eleni , Thodis Elias , Arsos George , Pasadakis Ploumis , Panagoutsos Stylianos , Papadopoulou Dorothea , Papagianni Aikaterini 
Published: July 2019

Abstract
Background: Fibroblast Growth Factor 23 (FGF-23) and α-Klotho contribute to the patho-genesis of chronic kidney disease - mineral and bone disorders (CKD-MBD). The aim of our study was to evaluate the association of FGF-23 and α-Klotho levels with CKD-MBD parameters, as well as with renal prognosis and mortality, in CKD patients stage 1-5, not in renal replacement therapy (RRT).

Methods: 128 patients were included. At enrollment GFR was measured (mGFR) and plasma levels of carboxyl terminal FGF-23 (cFGF-23) and soluble α-Klotho (sKlotho) were determined by ELISA. Abdominal aorta calcification (AAC) score was assessed in lateral abdominal X ray. The composite end point (event) was initiation of RRT or death. Follow-up was five years (median 36, range 2-60 months).

Results: mGFR significantly correlated with cFGF-23 and sKlotho negatively and posi-tievely respectively (p<0.0001 for both). Multiple regression analysis showed an inde-pendent correlation of cFGF-23 with mGFR, 25-OH vitamin D, presence of diabetes melli-tus and AAC score, of sKlotho with mGFR and phosphate and of AAC score with sKlotho and cFGF-23. Multivariate regression tree analysis, led to the formation of three regression groups (A, B, C) based on two “cut off” values: mGFR levels of 60.85 ml/min/1.73m2 and serum phosphate levels of 3.7 mg/dl. These groups significantly correlated with the five CKD stages and additionally cFGF-23 and sKlotho plasma levels (p<0.0001 for both). During follow-up, 40 out of the 128 patients, (31.2%) either initiated RRT or died (31 and 9 respectively). Kaplan Meier survival analysis showed that groups of patients with cFGF-23 levels less than median and those with sKlotho more than median value showing a more favorable course, regarding outcome (p=0.0003 for cFGF-23, p=0.004 for s-Klotho). In Cox regression analysis the association of cFGF-23 (p=0.04), sKlotho (p=0.008) and AAC score (p=0.01) with the presence of “event” remained significant after adjustment for traditional and CKD- related covariates.

Conclusions: In CKD patients stage 1-5, cFGF-23 and sKlotho levels are associated with adverse clinical outcomes. mGFR and serum phosphate, in association with sKlotho lev-els, may provide a “new classification” of CKD patients, which appears to be predictive of outcome.
The role of Vitamin D Receptor gene polymorphisms in colorectal cancer risk
Authors: Messaritakis Ippokratis , Koulouridi Asimina , Sfakianaki Maria , Gouvas Nikolaos , Athanasakis Elias , Tsiaoussis Ioannis , Xynos Evangelos , Mavroudis Dimitris , Tzardi Maria , Souglakos John 
Published: July 2019

Abstract
Background: Vitamin D deficiency has been associated with increased colorectal cancer (CRC) incidence risk and mortality. Vitamin D mediates its action through binding of the vitamin D receptor (VDR) and polymorphisms of the VDR might explain these inverse associations.
Methods: The aim of the study was the investigation of TaqI, ApaI, FokI and BsmI polymorphisms of the VDR gene for their relevance to colorectal carcinogenesis and progression. Peripheral blood was obtained from 397 patients with early operable stage II/III (n=202) and stage IV (n=195) CRC. Moreover, samples from 100 healthy donors and 40 patients with adenomatous polyps were also included as control groups. Genotyping in samples from patients and controls was performed using PCR-RFLP.
Results: A significant association revealed between all four polymorphisms and cancer. Individuals with homozygous mutant (tt, aa, ff or bb) genotype are more susceptible to the disease (p<0.001). All mutant genotypes detected were also significantly associated with the stage IV disease (p<0.001) leading to significantly decreased survival (p<0.001). Moreover, all four polymorphisms were significantly associated with KRAS mutations and with TLR2, TLR4 and TLR9 genetic variants. In multivariate analysis, tt, aa and ff genotypes emerged as independent factors associated with decreased OS (p=0.001, p<0.001 and p=0.001, respectively).
Conclusions: The detection of higher frequencies of the VDR polymorphisms in CRC patients highlights the role of these polymorphisms in cancer development and progression.
Serum gamma-glutamyltransferase and the overall survival of metastatic pancreatic cancer
Authors: Xiao Yuanyuan , Yang Haijun , Lu Jian , Li Dehui , Xu Chuanzhi , Risch Harvey A. 
Published: July 2019

Abstract
Background

Accumulating evidence suggests that Gamma-glutamyltransferase (GGT) may be involved in cancer occurrence and progression. However, a prognostic role of serum GGT in pancreatic cancer (PC) survival lacks adequate evaluation. In this study, we aimed to analyze the association between serum GGT measured at diagnosis and overall survival (OS) in patients with metastatic PC.

Methods

We identified 320 patients with histopathologically confirmed metastatic pancreatic ductal adenocarcinoma (PDAC) diagnosed during 2015 and 2016 at a specialized cancer hospital in southwest China. Univariate and multivariate Cox proportional hazards models were used to determine associations between serum GGT and OS in metastatic PDAC.

Results

Under control for possible confounding factors, serum GGT was significantly associated with OS: serum GGT >48 U/L yielded a hazard ratio of 1.53 (95%CI: 1.19-1.97) for mortality risk. Significant dose-response between serum GGT and OS was also observed. Subgroup analysis showed some evidence for an interaction between GGT and blood glucose level.

Conclusion

Serum GGT could be a promising indicator of survival in metastatic PDAC patients. Underlying mechanisms for this association should be investigated.
Prevalence and Localization of Hibernating Myocardium Among Patients with Left Ventricular Dysfunction
Authors: Acar Emine , Aksu Ayşegül , Akkaya Gökmen , Kaya Gamze Çapa 
Published: July 2019

Objective:
This study evaluated how much of the myocardium was hibernating in patients
with left ventricle dysfunction and/or comorbidities who planned to undergo either surgical
or interventional revascularization. Furthermore, this study also identified which irrigation areas of
the coronary arteries presented more scar and hibernating tissue.

Methods:
At rest, Tc-99m MIBI SPECT and cardiac F-18 FDG PET/CT images collected between
March 2009 and September 2016 from 65 patients (55 men, 10 women, mean age 64±12) were retrospectively
analyzed in order to evaluate myocardial viability. The areas with perfusion defects
that were considered metabolic were accepted as hibernating myocardium, whereas areas with perfusion
defects that were considered non-metabolic were accepted as scar tissue.

Results:
Perfusion defects were observed in 26% of myocardium, on average 48% were associated
with hibernation whereas other 52% were scar tissue. In the remaining Tc-99m MIBI images, perfusion
defects were observed in the following areas in the left anterior descending artery (LAD;
31%), in the right coronary artery (RCA; 23%) and in the Left Circumflex Artery (LCx; 19%)
irrigation areas. Hibernation areas were localized within the LAD (46%), LCx (54%), and RCA
(64%) irrigation areas. Scar tissue was also localized within the LAD (54%), LCx (46%), and RCA
(36%) irrigation areas.

Conclusion:
Perfusion defects are thought to be the result of half hibernating tissue and half scar
tissue. The majority of perfusion defects was observed in the LAD irrigation area, whereas hibernation
was most often observed in the RCA irrigation area. The scar tissue development was more
common in the LAD irrigation zone.
Head and Neck Cancer with Lung Metastases: Treatment Challenges
Authors: Vengathajalam Selvamalar , Lazim Norhafiza Mat 
Published: July 2019

Background:Head and neck cancer has predilection of metastasising to the lung, bones or liver. The site of metastasis usually depends on the primary tumour location, the staging and the regional spread of the tumour. Patients with distant metastasis are predicted to have a poor prognosis with low survival rate. Oligometastasis is the term used for an intermediate biologic state of restricted metastatic capacity with limited number and sites of organ with metastasis. It is also defined by 5 or less than 5 metastatic lesion in a disease with a controlled primary tumour.Case Reports:In this case series, we have reported three cases of head and neck carcinomas that pose treatment dilemmas because of lung metastases. First case is a gentleman with laryngeal carcinoma with multiple small lung metastases where the treatment options of surgery versus chemoradiation was debated. The second case is a gentleman with low grade mucoepidermoid carcinoma of the parotid gland with suspicious lung spread of disease. Lastly is a patient with papillary thyroid carcinoma with florid lung metastases who completed chemoradiation.Conclusion:The presence of lung metastases does not necessarily mean that the prospect of surviving is poor for the patient. It is necessary to determine the best choice of treatment yielding the best quality of life to maximize the survival period for these patients.
Pengaruh pendekatan latihan dan koordinasi mata tangan terhadap ketepatan shooting peserta ekstrakurikuler basket
Authors: Hermawan Desi Adityo , Rachman Hari Amirullah 
Published: July 2019

Penelitian ini bertujuan untuk (1) mengetahui pengaruh antara pendekatan latihan teknis dan taktis dengan ketepatan shooting; (2) mengetahui pengaruh antara kemampuan motorik koordinasi mata dan tangan terhadap ketepatan shooting; (3) mengetahui interaksi pengaruh antara pendekatan latihan dan koordinasi mata dan tangan dengan ketepatan shooting. Penelitian ini merupakan penelitian eksperimen dengan menggunakan rancangan 2x2. Subjek penelitian ini yaitu siswa SMP Negeri 1 Sumpiuh dan siswa SMP Negeri 2 Sumpiuh yang mengikuti ekstrakurikuler bola basket. Teknik pengambilan sampel menggunakan teknik purposive random sampling dengan total responden sebanyak 20 orang. Instrumen pengumpulan data menggunakan tes pengukuran. Analisis data menggunakan ANOVA dua jalur (ANOVA two-way). Hasil penelitian menunjukkan (1) ada perbedaan yang signifikan pendekatan teknis, dan taktis mempengaruhi ketepatan shooting dalam permainan bola basket; (2) ada perbedaan pengaruh yang signifikan kemampuan motorik koordinasi mata dan tangan dengan ketepatan shooting dalam permainan bola basket; (3) ada interaksi yang signifikan antara pendekatan latihan dan koordinasi mata tangan dengan ketepatan shooting dalam permainan bola basket. The influence of training approach and eyes-and-hands coordination on shooting accuracy in the participant’s basket extracurricular activity AbstractThe study was conducted in order to: (1) identify the influence of technical and tactical practice on shooting accuracy; (2) identify the influence of motoric capacity within the eyes-and-hands coordination on shooting accuracy; and (3) identify the influence of training approach and eyes-and-hands coordination on shooting accuracy. The study was a 2x2 experiment and the subjects in the study were the students of Negeri 1 Sumpiuh State Junior High School who attended the basketball extracurricular activity. The samples in the selected by means of purposive random sampling technique with total number of respondents 20 people. In gathering the data, a measurement test was administered among the students and the data were analysed by using two-way ANOVA. The results of the study show that: (1) the technical and tactical practice has significant influence on shooting accuracy within the basketball game; (2) the motoric capacity within the eyes-and-hands coordination has significant influence on shooting accuracy within the basketball game; and (3) the eyes-and-hands training and coordination approach has significant influence on shooting accuracy within the basketball game.
Ruang terbuka olahraga di Kecamatan Gunungpati, Kota Semarang: Kajian analisis melalui sport development index
Authors: Dharmawan Dhimas Bagus , Ichsandi Rofa , Faza Ricka Ulfatul 
Published: July 2019

Tujuan penelitian ini adalah mengidentifikasi ruang terbuka olahraga di Kecamatan Gunungpati dalam memfasilitasi masyarakat berolahraga yang ditinjau dari Sport Development Index (SDI). Dalam penelitian ini metode yang digunakan adalah metode survei dengan pendekatan deskriptif kuantitatif yang ditinjau dari SDI. Instrumen penelitian yang digunakan adalah observasi dan wawancara, selanjutnya data yang diperoleh dianalisis secara kuantitatif dengan menggunakan analisis SDI dari dimensi ruang terbuka. Hasil penelitian ini adalah berupa data jumlah ruang terbuka olahraga yang ada di Kecamatan Gunungpati adalah 34 ruang terbuka olahraga dengan total luas 43.854,5 m2, sedangkan jumlah populasi penduduk yang ada adalah berjumlah 12.817 jiwa yang dijadikan sebagai sampel, selanjutnya didapatlah indeks ruang terbuka olahraga di Kecamatan Gunungpati adalah 0,97. Dapat disimpulkan nilai indeks ruang terbuka yang didapat menunjukkan jika di tinjau dari norma SDI ketersediaan ruang terbuka olahraga di Kecamatan Gunungpati sudah masuk dalam kategori tinggi. Open space area sports in Subdistrict Gunungpati, Semarang City: The study of analysis through sport development index Abstract The purpose of this research is to identify open space sports in district Gunungpati to facilitating the exercise Community riview of Sport Development Index (SDI). In this study the method used is descriptive survey methods with quantitative approach review of SDI. Research instrument used observation and interviews, further data obtained were analyzed quantitatively using the SDI analysis of the dimensions of the open space. The results of this research data is a number of open spaces sports existing in District Gunungpati is 34 open space sports with a total area of 43,854.5 m2, while the existing population was totaled 12,817 souls who serve as the sample, the conclucions is index of open space sports in District Gunungpati is 0.97. The index values can be summed up open space obtained shows if the review than the norm of the SDI open space sports availability in District Gunungpati already entered in the category.
Perbedaan tingkat keberhasilan 3 metode ekualisasi pada penyelam terlatih di lingkungan air tawar
Authors: Arbanto Bonifacius , Putra Kukuh Pambuka , Al Ardha Muchamad Arif 
Published: July 2019

Penyelam mengalami penambahan tekanan lingkungan ketika bergerak turun menambah kedalaman penyelaman. Tekanan tersebut menyebabkan volume ruang udara dalam telinga tengah berkurang dan dapat menyebabkan barotrauma dan kerusakan membran timpani. Tekanan tersebut harus diseimbangkan dengan cara melakukan ekualisasi. Ada tiga metode ekualisasi, yaitu metode valsava, toynbee dan menggerakkan rahang. Namun belum diketahui metode mana yang memiliki tingkat keberhasilan tertinggi. Penelitian ini mempelajari tingkat keberhasilan ketiga metode ekualisasi dengan membandingkan kedalaman yang berhasil dicapai oleh penyelam menggunakan tiga metode yang berbeda. Penelitian ini dilakukan pada 40 orang penyelam terlatih di lingkungan kolam air tawar dengan kedalaman 5 meter. Variabel yang diukur adalah angka kedalaman (dalam meter) yang berhasil dicapai penyelam. Hasil penelitian menunjukkan terdapat perbedaan yang signifikan antara capaian kedalaman menggunakan metode valsava dengan capaian kedalaman menggunakan metode toynbee (p<0,05) dan terdapat perbedaan yang signifikan pula antara capaian kedalaman menggunakan metode valsava dengan capaian kedalaman menggunakan metode menggerakkan rahang (p<0,05). Namun tidak didapati adanya perbedaan yang signifikan antara data capaian kedalaman menggunakan metode menggerakkan rahang dengan capaian kedalaman menggunakan metode toynbee (p>0,05). Difference in success rate of 3 equalize method among trained divers in the freshwater environment AbstractDivers experience increase of environmental pressure when the diver descends. This pressure causes the volume of air space in the middle ear to decrease, can cause barotrauma and tympanic damage. This pressure must be equalize. There are three methods of equalization, valsava maneuver, toynbee and moving the jaw. But it is not known which method has the highest success rate. This research studied the success rate of the three methods of equalization by comparing the depth achieved by divers using the three different methods. This study was conducted on 40 trained divers in the freshwater pool with 5 meters depth. The variable measured is the number of depths (in meters) successfully achieved by divers. The results of this study showed that there was a significant difference between the depth achieved using the Valsava maneuver with the depth achieved using the toynbee maneuver (p <0.05) and there were also significant differences between the depth achieved using the Valsava maneuver with depth achieved using the jaw moving method (p <0, 05). However, there was no significant difference between the depth achieved using the jaw moving method with depth achieved using the toynbee maneuver (p> 0.05).
Penerapan budaya 7K untuk siswa sekolah dasar
Authors: Budiarti Any , Sriawan Sriawan 
Published: July 2019

Penelitian ini bertujuan untuk mengetahui pelaksanaan penerapan budaya 7K (Keamanan, Kenyamanan, Kebersihan, Ketertiban, Keindahan, Kekeluargaan, dan Kerindangan) yang dilakukan oleh siswa kelas IV, V, VI di SD Negeri 7 Kebumen, Kecamatan Kebumen. Desain penelitian ini adalah penelitian deskriptif dengan metode survei. Subjek dari penelitian ini adalah seluruh siswa kelas IV, V, VI di SD Negeri 7 Kebumen, Kecamatan Kebumen. Jumlah siswa keseluruhan yang diteliti sebanyak 100 siswa. Teknik pengambilan data menggunakan angket. Validitas kontsruk instrumen penelitian dengan expert judgement dan validitas instrumen angket dilakukan dengan analisis butir. Uji reliabilitas menggunakan rumus Alpha Cronbach. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis data statistik deskriptif. Hasil penelitian disimpulkan bahwa penerapan budaya 7 K pada faktor yang dikategorikan sangat baik ada 2 faktor yaitu ketertiban dan kekeluargaan dengan presentase keseluruhan sebesar 28,6%, pada kategori baik ada 4 faktor yaitu keamanan, kenyamanan, kebersihan dan keindahan dengan presentase keseluruhan sebesar 57,1%, pada kategori cukup ada 1 faktor yaitu kerindangan dengan presentase keseluruhan sebesar 14,3%, dan kategori tidak baik dengan presentase 0%. Sehingga hasil penelitian penerapan budaya 7 K di SD Negeri 7 Kebumen, Kecamatan Kebumen adalah baik. Application of 7K culture for elementary school students AbstractThe aim of this research is to know the implementation of 7K culture (security, comfort, hygiene, orderliness, beauty, kinship, and shade) done by grade IV, V, VI students at primary public school 7 Kebumen. The design of this research is descriptive research with survey method. The subject of this research is all students. Total students were 100 students. Technique of taking data using questionnaire. The validity of research instruments using expert judgment and validity of questionnaire instrument is done by item analysis. Technique of data analysis used in this research is descriptive statistical data analysis. The result of this research can be concluded that 7 K culture enrichment on factor which is categorized very good there are 2 factors that is orderliness and kinship with total percentage equal to 28,6%, good category there are 4 factor that is security, comfort, hygiene and beauty with total percentage equal to 57 , 1%, in the category enough there is one factor that is shade with the overall percentage of 14.3%, and the category is not good with a percentage of 0%. So the results of research implementation of culture 7 K in primary public school District is good.