bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Speech Chunking in Reading Aloud is a Marker of Mild Cognitive Impairment and Mild-to-Moderate Alzheimer’s Disease
Authors: De Looze Celine , Kelly Finnian , Crosby Lisa , Vourdanou Aisling , Coen Robert F. , Walsh Cathal , Lawlor Brian A. , Reilly Richard B. 
Published: April 2018

Background:
Speech and Language Impairments, generally attributed to lexico-semantic
deficits, have been documented in Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD).
This study investigates the temporal organisation of speech (reflective of speech production planning) in
reading aloud in relation to cognitive impairment, particularly working memory and attention deficits in
MCI and AD. The discriminative ability of temporal features extracted from a newly designed read
speech task is also evaluated for the detection of MCI and AD.

Method:
Sixteen patients with MCI, eighteen patients with mild-to-moderate AD and thirty-six healthy
controls (HC) underwent a battery of neuropsychological tests and read a set of sentences varying in
cognitive load, probed by manipulating sentence length and syntactic complexity.

Results:
Our results show that Mild-to-Moderate AD is associated with a general slowness of speech,
attributed to a higher number of speech chunks, silent pauses and dysfluences, and slower speech and
articulation rates. Speech chunking in the context of high cognitive-linguistic demand appears to be an
informative marker of MCI, specifically related to early deficits in working memory and attention. In
addition, Linear Discriminant Analysis shows the ROC AUCs (Areas Under the Receiver Operating
Characteristic Curves) of identifying MCI vs. HC, MCI vs. AD and AD vs. HC using these speech characteristics
are 0.75, 0.90 and 0.94 respectively.

Conclusion:
The implementation of connected speech-based technologies in clinical and community
settings may provide additional information for the early detection of MCI and AD.
Biopharmaceutical Potential of Selegiline Loaded Chitosan Nanoparticles in the Management of Parkinson's Disease
Authors: Rukmangathen Rajalakshmi , Yallamalli Indira Muzib , Yalavarthi Prasanna Raju 
Published: April 2018

Background:
Selegiline hydrochloride, a hydrophilic anti-Parkinson’ moiety, undergoes extensive
first-pass metabolism and has low bioavailability. A process to obtain of selegiline (SH) loaded chitosan
nanoparticles was attempted to circumvent the above problem, through intranasal delivery.

Methods:
SH loaded polymeric nanoparticles were prepared by ionic gelation of chitosan with
tripolyphosphate, and stabilized by tween 80/ poloxamer 188. The resulting nanoparticles (NPs) were
characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, entrapment
efficiency, particle size, zeta potential and surface morphology by scanning electron microscopy. Further, they
were schematically evaluated for mucoadhesive strength, in-vitro drug release, release kinetics,
pharmacokinetics, catalepsy, akinesia, in-vivo lipid peroxidation, nitrite levels, glutathione, catalase enzyme
levels in brain and physicochemical stability parameters.

Results:
Selegiline nanoparticles (SP18) produced were in size of 63.1 nm, polydispersity index of 0.201, zeta
potential of +35.2 mV, mucoadhesion of 65.4% and entrapment efficiency of 74.77%. Selegiline showed biphasic
release from nanoparticles, over a period of 36 h, with Fickian diffusion controlled release profile. Maximum
concentration of SH in plasma was recognized as 52.71 ng/ml at 2 h for SP18, 20.09 ng/ml at 1 h for marketed
formulation, and 21.69 ng/ ml for drug solution. SH loaded NPs showed a reversive effect in catalepsy and akinesia
behaviour. This effect was especially pronounced in rats receiving SH loaded CS-NPs. Significant decrease in lipid
peroxidation and nitrite concentration; increase in reduced glutathione and catalase enzyme levels were obtained
due to antioxidant characteristics of SH, which turned to be useful to treat Parkinson’s disease.

Conclusion:
Selegiline loaded chitosan nanoparticles form an effective non-invasive drug delivery
system of direct nose to brain targeting in Parkinson’s disease.
Justicia autónoma frente a justicia oficial
Authors: Fernández Christlieb Paulina 
Published: April 2018

<span style="font-family: Helvetica; font-size: xx-small;"><span style="font-family: Helvetica; font-size: xx-small;"><span style="font-family: Helvetica; font-size: xx-small;"><p>En este trabajo se exponen las diferencias que oponen la concepción occidental de justicia a la de pueblos indígenas de América Latina. Se parte de las disposiciones internacionales como el</p></span></span></span><p> </p><p><em><span style="font-family: Helvetica-Oblique; font-size: xx-small;"><span style="font-family: Helvetica-Oblique; font-size: xx-small;">Convenio 169 </span></span></em><span style="font-family: Helvetica-Oblique; font-size: xx-small;"><span style="font-family: Helvetica-Oblique; font-size: xx-small;"> </span></span><span style="font-family: Helvetica; font-size: xx-small;"><span style="font-family: Helvetica; font-size: xx-small;">de la OIT y la </span></span><em><span style="font-family: Helvetica-Oblique; font-size: xx-small;"><span style="font-family: Helvetica-Oblique; font-size: xx-small;">Declaración de la ONU sobre los Derechos de los Pueblos Ind</span></span></em><em><span style="font-family: Helvetica-Oblique; font-size: xx-small;"><span style="font-family: Helvetica-Oblique; font-size: xx-small;">ígenas </span></span></em><span style="font-family: Helvetica; font-size: xx-small;"><span style="font-family: Helvetica; font-size: xx-small;">y se analiza la reforma al artículo 2 de la Constitución mexicana para demostrar que </span></span><span style="font-family: Helvetica; font-size: xx-small;"><span style="font-family: Helvetica; font-size: xx-small;">todas estas normas legales anulan el contenido de los </span></span><em><span style="font-family: Helvetica-Oblique; font-size: xx-small;"><span style="font-family: Helvetica-Oblique; font-size: xx-small;">Acuerdos de San Andrés </span></span></em><span style="font-family: Helvetica; font-size: xx-small;"><span style="font-family: Helvetica; font-size: xx-small;">en cuanto a </span></span><span style="font-family: Helvetica; font-size: xx-small;"><span style="font-family: Helvetica; font-size: xx-small;">la administración de justicia autónoma por parte de los pueblos indígenas.</span></span></p>
Los libros de ajedrez en España (c. 1770-1899): bibliografía histórica
Authors: Brasó i Rius Jordi 
Published: April 2018

Se presenta un repertorio bio-bibliográfico y un estudio bibliométrico histórico de las obras de ajedrez en España, desde finales del siglo XVIII hasta finales del siglo XIX. Se ha utilizado una metodología basada en la búsqueda y análisis en los fondos documentales de la época y en las bases de datos de las bibliotecas actuales, principalmente de España. La fase interpretativa, junto con un análisis estadístico de cuatro factores –periodo de publicación de las obras, lugar de edición, originalidad o traducción, y tipología– permite describir cada una de las obras de ajedrez publicadas en España, además de contextualizarlas con el momento social de la época. El estudio bibliométrico refuerzaasí el análisis interpretativo sobre la producción ajedrecística española.
DOES JOB ROTATION AND JOB SATISFACTION AFFECT THE PERFORMANCE?
Authors: Muazza Muazza , Syarifuddin H Bonar 
Published: April 2018

The purpose of this research: (1) To know the description of job rotation, job satisfaction and employee performance at the Jambi Provincial Transportation Department. (2) To know the effect of job rotation on employee performance at the Jambi Provincial Transportation Department. (3) To know the effect of job satisfaction on employee performance at the Department of Transportation of Jambi Province. (4) To know the influence between job rotation and job satisfaction on employee performance at the Department of Transportation of Jambi Province.The method of this research is descriptive and quantitative and using regresion method. The population in the study were the employees of the Jambi Provincial Transportation Department. Technique of sampling research using of stratified sampling. The total sample in this study was 123 respondents.The result of the research shows that the average level of the respondent's answer for job rotation (X1) is 74.46% and the average level of the respondent answer for job satisfaction variable (X2) is 68.52, it shows highest average respondent There is in position variable rotation (X1). The magnitude of the effect of rotation variables on the performance of employees at the Department of Transportation Jambi Province is amounted to 2,427. The amount of influence of job satisfaction on employee performance variables at the Jambi Provincial Transportation Department is 4.452. Based on the analysis that together into two independent variables of job rotation and job satisfaction have a significant effect amounted to 2.201 (X1) dan 3.308(X2) on the performance of employees at the Transportation Agency of Jambi Province.
Keywords: Job Rotation, Job Satisfaction, Employee Performance
Macroscopic Study of Celiac, Cranial Mesenteric and Caudal Mesenteric Arteries in the European Hare
Authors: Flešárová S. , Maženský D. 
Published: April 2018

Abstract
The aim of this paper was to describe the branching schema of the ventral branches of the abdominal aorta: the a. celiaca, the a. mesenterica cranialis and the a. mesenterica caudalis. The study was carried out on nine adult European hares using the corrosion cast technique. After the euthanasia, the vascular network was perfused with saline. Batson’s corrosion casting kit No. 17 was used as a casting medium. After polymerisation of the medium, the maceration was carried out in KOH solution. In all specimens, the first branch originating from the a. celiaca was the a. lienalis. The a. hepatica was present as the second branch in four cases and as the third branch also in four cases. The first branch of the a. mesenterica cranialis was the a. colica media in seven cases. The second branch was represented by the a. pancreaticoduodenalis caudalis also in seven cases. Two aa. jejunales originated as the third branch. In seven cases, the fourth branch formed the truncus jejunalis and the fifth branch the a. ileocecalis. The a. mesenterica caudalis had a uniform arrangement in all of the specimens. The results enabled us to conclude that there was higher variability of the branching pattern of the a. celiaca in comparison with the a. mesenterica cranialis and the a. mesenterica caudalis in the European hare.
Immunohistochemical Study of the Goat Ductus deferens
Authors: Marettová E. , Maretta M. 
Published: April 2018

Abstract

Ductus deferens plays an important role in sperm transport and participates in the preservation of structure, maturation, and viability of sperm. In this study, we have immunohistochemically examined the ductus deferens in the goat. For immunohistochemical study the following monoclonal antibodies were used: cytokeratin 18, α-smooth muscle actin (α-SMA), vimentin and elastin. Morphologically, three distinct layers were identified in the goat ductus deferens — tunica mucosa, tunica muscularis and tunica adventitia. The epithelium of the mucosa was intensely stained with cytokeratin 18 (CK 18). The fibroblasts in the lamina propria and blood capillaries in the muscle layer showed positive reaction for vimentin. A positive reaction for α-SMA was observed in the smooth muscle cells of the tunica muscularis in the internal, middle and outer sublayers. An intense positive reaction for α-SMA was observed in the wall of the blood vessels. Elastic fibers in the form of a loose meshwork were present in all three layers. The high density of elastic fibers were found in the tunica adventitia.
Contribution of Pili of S. Pneumoniae in the Onset of Meningitis
Authors: Jiménez-Munguía I. , Pulzová L. , Bhide K. , Čomor Ľ. , Káňová E. , Tomečková Z. , Širochmanová I. , Bhide M. 
Published: April 2018

Abstract
Bacterial meningitis is a devastating worldwide disease. Half of the survivors of meningitis remain with permanent neurological sequelae. The pathogenesis of meningitis is based on a complex host-pathogen interaction. Streptococcus pneumoniae is a life-threatening neuroinvasive pathogen that asymptomatically colonizes the upper respiratory tract. Adherence of pneumococci to the host epithelium is a prerequisite in the onset of streptococcal infections; such adherence is favored by the formation of bacterial pili. In this article, we will describe the pneumococcal pili and its contribution to the onset of meningitis.
Use of high performance technologies in the treatment of chronic neuropathic pain
Authors: Streltov Ion , Nour Marcela , Radu Madalina , Malcoci Mihai , Bisoc Oana , Olaru Ecaterina , Aldea Iulia 
Published: April 2018

AbstractSpinal cord neurostimulation is a minimally invasive treatment method for chronic neuropathic pain that is refractory to treatment, and is part of top technology in field. Relatively recent introduction of this method in the Neurosurgery Clinic “Prof. Dr. N. Oblu” of Iasi has aligned the clinic’s therapeutic arsenal to world standards. This has made it possible to treat in Romania a category of patients who would be treated abroad until now. Our clinic has entered the “National Program for diagnostic and treatment using high performance equipment” - Subprogram of treatment of neuropathic pain by implant of a spinal cord neurostimulator and is currently the only one in Romania where this treatment can be done. This represents a new step in the transformation process of the Clinical Hospital Emergency “Prof. Dr. N. Oblu” Iasi in a real Center of Excellence in the field Neurosurgery. The team dealing with the implant consists of 3 neurosurgeons, a neurologist, pa sychologist and an anesthetist, trained in a specialized foreign center.
Preoperative mapping of the eloquent cortical areas using navigated transcranial magnetic stimulation combined with intraoperative neuronavigation for intracerebral lesions
Authors: Petrescu G. , Gorgan Cristina , Giovani A. , Brehar F.M. , Gorgan R.M. 
Published: April 2018

Abstract
Introduction: Maximal surgical resection with the preservation of cortical functions is the treatment of choice for brain tumors. Achieving these objectives is especially difficult when the tumor is located in an eloquent area. Navigated transcranial magnetic stimulation (nTMS) is a modern non-invasive, preoperative method for defining motor and speech eloquent areas.
Material and methods: Patients with tumors located in motor and speech eloquent areas who presented at our institution between March 2017 and December 2017 were prospectively included. Exclusion criteria were frequent generalized epileptic seizures and cranial implants. For lesions involving motor eloquent areas we performed a nTMS motor mapping and for lesions involving speech eloquent areas we supplemented the motor mapping with speech and language mapping. MR images were exported from the nTMS system in a DICOM format and then loaded in the intraoperative neuronavigation system. Based on these findings, the optimal entry point and trajectory were determined, in order to achieve a maximum surgical resection of the lesion, while avoiding new post-operative neurological deficits.
Results: Nineteen patients underwent an nTMS brain mapping procedure between March 2017 and December 2017. In all cases a motor mapping procedure was done, but only in eight cases a speech mapping was also performed. Three patients presented new minor postoperatory deficits that consecutively remitted. The rest of the patients presented no added neurological deficits after surgery. In five cases the preexistent deficit was ameliorated after surgery and in three cases the deficit remitted. In one patient there was no improvement in the neurologic deficit after surgery.
Conclusion: nTMS is a reliable tool for the preoperative planning of eloquent area lesions. It must be taken into account that functional areas have a high individual variability. Therefore, knowing preoperatively the extent of the eloquent area helps the neurosurgeon adapt the surgical approach in order to obtain a better functional outcome.
Real-time patency verification during clipping aneurysm and STA-MCA by-pass with dual-image videoangiography
Authors: Tanaka Riki , Shatokhin Anton , Senko Ilya , Bishnoi Ishu , Sae-Ngow Treepob , Yamada Yasuhiro , Suyama Daisuke , Kawase Tsukasa , Kato Yoko , Ansari Ahmed 
Published: April 2018

Abstract
The dual-image videoangiography (DIVA) is a new tool which helps identify vessels and surrounding structure. This method is based on use of indocyanine green video angiography (ICG-VA) technology on real time microscopic operative image. In this two case, we report of using DIVA in STA-MCA bypass surgery of 46 years old, female patient of stenosis of right MCA. And using DIVA during clipping ICA paraclinod aneurysm of 35 years old, female. During surgery, it helped in identifying temporal and frontal branches of the STA and there careful selection. After anastomosis, DIVA was used to refine vessel patency and functioning of the anastomosis. DIVA has the potential to replace ICG-VA as a tool for checking the patency of graft during bypass procedures and obliteration of aneurysm along with surgical procedures for AVM and d-AVF. DIVA allows visualization of vessels against a background of normal brain and has better visualization at greater depth and high magnification. This is particularly important during bypass surgery, which very often is performed in deep surgical fields and high magnification.
Outcome of medial sphenoidal wing meningioma surgery
Authors: El Badry Ashraf , Abdelazeez Azza 
Published: April 2018

Abstract
Background: Sphenoid wing meningiomas among difficult surgery tumours due to involvement of important structures like optic nerve, cavernous sinus or carotid artery.
Objective: to evaluate outcome and prognostic factors in patients with medial sphenoid wing meningiomas after microsurgery in a series of 47 patients with medial sphenoid wing meningioma.
Method: This paper includes analysis of 47 patients & their data who underwent surgical management for meningiomas involving the medial sphenoid wing in the period between Jan 2008 and February 2016 at Mansoura university hospital.
Results: The most of patients were suffering from visual impairment (59.6%), followed by headaches (38.2%). Total tumor resection were achieved in 23 cases, incomplete in 19 cases and partial resection in 5 cases. Visual acuity improved or stable in 57.4% of the patients. Preoperative neurological deficit remains unchanged postoperative in 35 cases while improved in 4 cases. 8 cases developed permanent 3rd Nerve palsy. Tumor recurrence was in 7 patients.
Conclusion: There are many factors influence the prognosis of inner sphenoid wing meningioma including the extent of surgical resection, cavernous sinus invasion, present or absent of peritumoral edema, vascularity of the tumor, size of the tumor, presence or absence of arachnoid plane between the tumor and surrounding neurovascular structures and preoperative neurological condition
Efficacy of carotid thrombus penetration with a balloon guiding catheter to fast recanalization of acute extra- and intra-cranial carotid artery tandem occlusion - a preliminary report
Authors: Ansari Ahmed , Ohshima Tomotaka , Goto Shunsaku , Yamamoto Taiki , Ishikawa Kojiro , Kato Yoko 
Published: April 2018

Abstract
Acute ischemic stroke with ipsilateral Internal carotid artery (ICA) stenosis presents a great management dilemma. We present our preliminary report of retrograde retrieval of clot from middle cerebral artery (MCA) followed by delayed carotid artery stenting (CAS) with dual anti platelet therapy (DAPT).
Poesiintresserade unga i Sverige
Authors: Sigvardsson Anna 
Published: April 2018

Poetry reading is since 2011 part of the core content in the subject of Swedish at both primary and secondary level. However, to date there is little research on poetry pedagogy that may provide guidance to teachers and poetry reading pedagogy for secondary students is an especially understudied area. Early research has developed knowledge on poetry reception in class but little is known about how secondary students read and use poetry in their spare time. Knowledge of the leisure uses of poetry could have implications for pedagogy. The aim of this study is to map and develop knowledge of how keen readers of poetry became interested in the genre and use poetry today in their spare time. The material consists of 21 semi-­structured online interviews. The analysis shows that participants tend to come from families that read and value literature. The participants generally develop an interest in poetry during late adolescence. Reading is the most common leisure activity. There is little online activity with poetry in the group. Many read poetry to be inspired and integrate what they read in other texts, images and music. Participants tend to prefer lyric poetry and a male western canon is dominant in their examples of favourite poets.
Adopsi Inovasi Program Keluarga Berencana oleh Akseptor dari Komunitas Adat Terpencil Baduy diKecamatan Leuwidamar Kabupaten Lebak
Authors: Sihabudin Ahmad , Mutjaba Burhanudin , Dimyati Idi 
Published: April 2018

<p>Adanya trend peningkatan akseptor Keluarga Berencana (KB) pada Komunitas Adat Terpencil (KAT) Baduy Kecamatan Leuwidamar Kabupaten Lebak Banten. Data menunjukkan Tahun 2006 Akseptor KB di Baduy Luar berjumlah 647 peserta, per bulan Pebruari 2014 jumlah akseptor KB Baduy Luar 1403 peserta, dan akseptor di Baduy dalam 16 peserta. Selain itu ada variasi penggunaan alat kontrasepsi yang dipakai, pada masa awal KAT Baduy menerima konsep KB kebanyakan mereka menggunakan implant. Dari gejala tersebut penelitian ini dirancang dengan tujuan untuk mengetahui jenis dan ciri inovasi KB, saluran atau media apa dalam penyebaran KB; faktor-faktor karakteristik adopter apa saja yang mempengaruhi penerimaan KB. Metode penelitian yang digunakan adalah Survai explanasi. Jumlah sample penelitian sebanyak 100 orang. analisis dengan menggunakan distribusi frekuensi, dan untuk mengetahui hubungan antar peubah dilakukan analisis korelasi Spearman. Hasil penelitian menunjukkanUsia responden sebenarnya relatif terdistribusi mulai umur 13 sampai 45 tahun, paling banyak adalah usia 18-25 tahun. Jumlah putra yang dimiliki paling dominan antara 2 anak dan 4 anak.Jenis Pekerjaan responden sebagian besar adalah penenun kain. Jarak rumah tempat tinggal responden ke klinik kesehatan sebagian besar berjarak 2 jam perjalanan kaki ke klinik. Jenis alat KB (kontrasepsi) mayoritas perempuan Baduy Luar menggunakan suntik. Masa lama telah ber-KB, sebagian besar 1-3 Tahun, ada juga sudah 7-9 tahun dan yang lebih dari 10 tahun ber-KB ternayata cukup besar. Lama memutuskan ikut KB sebagian besar yakni 6 bulan. Saat awal ber KB mayoritas alat kontrasepsi yang merteka pilih dengan cara suntik. Alasan ber-KB jawaban yang paling banyak disebut adalah demi menjarangkan anak. Diperlukan pengembangan strategi agar perubahan terencana dapat dilakukan untuk lebih memenuhi kebutuhan akan keluarga berencana masyarakat adat baduy. Terdapat korelasi yang positif antara karakteristik akseptor KB dengan efektifitas penerimaan inovasi.Korelasi antara sistem sosial dengan efektifitas penerimaan inovasi bernilai negatif atau hampir tanpa pengaruh.Korelasi antara jenis saluran komunikasi dengan efektifitas penerimaan inovasi mempunyai hubungan yang cukup kuat.</p><p><em><br /></em><em></em></p>