bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in Mosquito Communities in Six Cities in Oklahoma
Authors: Bradt David , Wormington Jillian D , Long James M , Hoback W Wyatt , Noden Bruce H 
Published: April 2019

Abstract
Vector-borne diseases in the United States have recently increased as a result of the changing nature of vectors, hosts, reservoirs, pathogens, and the ecological and environmental conditions. Current information on vector habitats and how mosquito community composition varies across space and time is vital to successful vector-borne disease management. This study characterizes mosquito communities in urban areas of Oklahoma, United States, an ecologically diverse region in the southern Great Plains. Between May and September 2016, 11,996 female mosquitoes of 34 species were collected over 798 trap nights using three different trap types in six Oklahoma cities. The most abundant species trapped were Culex pipiens L. complex (32.4%) and Aedes albopictus (Skuse) (Diptera: Culicidae) (12.0%). Significant differences among mosquito communities were detected using analysis of similarities (ANOSIM) between the early (May–July) and late (August–September) season. Canonical correlation analysis (CCA) further highlighted the cities of Altus and Idabel as relatively unique mosquito communities, mostly due to the presence of Aedes aegypti (L.) and salt-marsh species and absence of Aedes triseriatus (Say) in Altus and an abundance of Ae. albopictus in Idabel. These data underscore the importance of assessing mosquito communities in urban environments found in multiple ecoregions of Oklahoma to allow customized vector management targeting the unique assemblage of species found in each city.
TP53 Status as a Determinant of Pro- vs Anti-Tumorigenic Effects of Estrogen Receptor-Beta in Breast Cancer
Authors: Mukhopadhyay Utpal K , Oturkar Chetan C , Adams Christina , Wickramasekera Nadi , Bansal Sanjay , Medisetty Rajesh , Miller Austin , Swetzig Wendy M , Silwal-Pandit Laxmi , Børresen-Dale Anne-Lise , Creighton Chad J , Park Jun Hyoung , Konduri Santhi D , Mukhopadhyay Alka , Caradori Alexander , Omilian Angela , Bshara Wiam , Kaipparettu Benny Abraham , Das Gokul M 
Published: April 2019

AbstractBackgroundAnti-tumorigenic vs pro-tumorigenic roles of estrogen receptor-beta (ESR2) in breast cancer remain unsettled. We investigated the potential of TP53 status to be a determinant of the bi-faceted role of ESR2 and associated therapeutic implications for triple negative breast cancer (TNBC).MethodsESR2-TP53 interaction was analyzed with multiple assays including the in situ proximity ligation assay. Transcriptional effects on TP53-target genes and cell proliferation in response to knocking down or overexpressing ESR2 were determined. Patient survival according to ESR2 expression levels and TP53 mutation status was analyzed in the basal-like TNBC subgroup in the Molecular Taxonomy of Breast Cancer International Consortium (n = 308) and Roswell Park Comprehensive Cancer Center (n = 46) patient cohorts by univariate Cox regression and log-rank test. All statistical tests are two-sided.ResultsESR2 interaction with wild-type and mutant TP53 caused pro-proliferative and anti-proliferative effects, respectively. Depleting ESR2 in cells expressing wild-type TP53 resulted in increased expression of TP53-target genes CDKN1A (control group mean [SD] = 1 [0.13] vs ESR2 depletion group mean [SD] = 2.08 [0.24], P = .003) and BBC3 (control group mean [SD] = 1 [0.06] vs ESR2 depleted group mean [SD] = 1.92 [0.25], P = .003); however, expression of CDKN1A (control group mean [SD] = 1 [0.21] vs ESR2 depleted group mean [SD] = 0.56 [0.12], P = .02) and BBC3 (control group mean [SD] = 1 [0.03] vs ESR2 depleted group mean [SD] = 0.55 [0.09], P = .008) was decreased in cells expressing mutant TP53. Overexpressing ESR2 had opposite effects. Tamoxifen increased ESR2-mutant TP53 interaction, leading to reactivation of TP73 and apoptosis. High levels of ESR2 expression in mutant TP53-expressing basal-like tumors is associated with better prognosis (Molecular Taxonomy of Breast Cancer International Consortium cohort: log-rank P = .001; hazard ratio = 0.26, 95% confidence interval = 0.08 to 0.84, univariate Cox P = .02).ConclusionsTP53 status is a determinant of the functional duality of ESR2. Our study suggests that ESR2-mutant TP53 combination prognosticates survival in TNBC revealing a novel strategy to stratify TNBC for therapeutic intervention potentially by repurposing tamoxifen.
Emerging mould infections: Get prepared to meet unexpected fungi in your patient
Authors: Dellière Sarah , Rivero-Menendez Olga , Gautier Cécile , Garcia-Hermoso Dea , Alastruey-Izquierdo Ana , Alanio Alexandre 
Published: April 2019

Abstract
Invasive fungal diseases are increasing issues in modern medicine, where the human immunodeficiency virus (HIV) pandemic and the wider use of immunosuppressive drugs generate an ever-growing number of immunocompromised patients with an increased susceptibility to uncommon fungal pathogens. In the past decade, new species have been reported as being responsible for disseminated and invasive fungal diseases in humans. Among them, the following genera are rare but seem emerging issues: Scopulariopsis, Hormographiella, Emergomyces, Westerdykella, Trametes, Actinomucor, Saksenaea, Apophysomyces, and Rhytidhysteron. Delay in diagnosis, which is often the case in these infections, jeopardizes patients’ prognosis and leads to increased mortality. Here we summarize the clinical and biological presentation and the key features to identify these emerging pathogens and we discuss the available antifungal classes to treat them. We focused on Pubmed to recover extensively reported human invasive cases and articles regarding the nine previously cited fungal organisms. Information concerning patient background, macroscopic and microscopic description and pictures of these fungal organisms, histological features in tissues, findings with commonly used antigen tests in practice, and hints on potential efficient antifungal classes were gathered. This review's purpose is to help clinical microbiologists and physicians to suspect, identify, diagnose, and treat newly encountered fungi in hospital settings.
White dwarf and subdwarf stars in the Sloan Digital Sky Survey Data Release 14
Authors: Kepler S O , Pelisoli Ingrid , Koester Detlev , Reindl Nicole , Geier Stephan , Romero Alejandra D , Ourique Gustavo , Oliveira Cristiane de Paula , Amaral Larissa A 
Published: April 2019

ABSTRACT
White dwarfs carry information on the structure and evolution of the Galaxy, especially through their luminosity function and initial-to-final mass relation. Very cool white dwarfs provide insight into the early ages of each population. Examining the spectra of all stars with 3σ proper motion in the Sloan Digital Sky Survey Data Release 14, we report the classification for 20 088 spectroscopically confirmed white dwarfs, plus 415 hot subdwarfs, and 311 cataclysmic variables. We obtain Teff, log  g, and mass for hydrogen atmosphere white dwarf stars (DAs), warm helium atmosphere white dwarfs (DBs), hot subdwarfs (sdBs and sdOs), and estimate photometric Teff for white dwarf stars with continuum spectra (DCs). We find 15 793 sdAs and 447 dCs between the white dwarf cooling sequence and the main sequence, especially below $T_\mathrm{eff}\simeq 10\, 000$ K; most are likely low-mass metal-poor main-sequence stars, but some could be the result of interacting binary evolution.
Inhomogeneous reionization models in cosmological hydrodynamical simulations
Authors: Oñorbe Jose , Davies F B , Lukić Z , Hennawi J F , Sorini D 
Published: April 2019

ABSTRACT
In this work we present a new hybrid method to simulate the thermal effects of reionization in cosmological hydrodynamical simulations. The method improves upon the standard approach used in simulations of the intergalactic medium (IGM) and galaxy formation without a significant increase in the computational cost, thereby allowing for efficient exploration of the parameter space. The method uses a small set of phenomenological input parameters, and combines a seminumerical reionization model to solve for the topology of reionization with an approximate model of how reionization heats the IGM, using the massively parallel Nyx hydrodynamics code which is specifically designed to solve for the structure of diffuse IGM gas. We have produced several medium-scale, high-resolution simulations (20483, Lbox = 40 Mpc h−1) with various instantaneous and inhomogeneous ${\rm H \,{\small I}}$ reionization models that use this new methodology. We study the IGM thermal properties of these models and find that large-scale temperature fluctuations extend well beyond the end of reionization. By analysing the 1D flux power spectrum of these models, we find up to ${\sim } 50{{\ \rm per\ cent}}$ differences in the large-scale properties (low modes, k ≲ 0.01 s km−1) of the post-reionization power spectrum as a result of the thermal fluctuations. We show that these differences could allow one to distinguish between different reionization scenarios with existing Lyα forest measurements. Finally, we explore the differences in the small-scale cut-off of the power spectrum, finding that, for the same heat input, models show very good agreement provided that the reionization redshift of the instantaneous reionization model occurs at the midpoint of the inhomogeneous model.
TESS observations of the asynchronous polar CD Ind: mapping the changing accretion geometry
Authors: Hakala Pasi , Ramsay Gavin , Potter Stephen B , Beardmore Andrew , Buckley David A H , Wynn Graham 
Published: April 2019

ABSTRACT
We present the results of near continuous TESS optical observations of the asynchronous polar CD Ind (RX J2115−5840). The 27.9 d long light curve, with 2 min resolution, reveals remarkable changes in the magnetic accretion geometry of the system over the 7.3 d beat period. We have modelled the changes in the optical spin period pulse shape using a cyclotron emission mapping technique. The resulting cyclotron emission maps of the magnetic white dwarf reveal how the accretion geometry changes from single- to two-pole accretion and back over the beat cycle. Finally, we present the results from particle-based numerical magnetic accretion simulations, which agree with our interpretation of the changing accretion scenario.
Active galactic nucleus selection in the AKARI NEP-Deep field with the fuzzy support vector machine algorithm
Authors: Poliszczuk Artem , Solarz Aleksandra , Pollo Agnieszka , Bilicki Maciej , Takeuchi Tsutomu T , Matsuhara Hideo , Goto Tomotsugu , Takagi Toshinobu , Wada Takehiko , Ohyama Yoichi , Hanami Hitoshi , Miyaji Takamitsu , Oi Nagisa , Malkan Matthew , Murata Kazumi , Kim Helen , Tello Jorge Díaz ,   NEP Team
Published: April 2019

Abstract
The aim of this work is to create a new catalog of reliable active galactic nucleus (AGN) candidates selected from the AKARI NEP-Deep field. Selection of the AGN candidates was done by applying a fuzzy support vector machine algorithm, which allows the incorporation of measurement uncertainties into the classification process. The training dataset was based on the spectroscopic data available for selected objects in the NEP-Deep and NEP-Wide fields. The generalization sample was based on the AKARI NEP-Deep field data, including objects without optical counterparts and making use of the infrared information only. A high quality catalog of 275 previously unclassified AGN candidates was prepared.
A Chandra and ALMA study of X-ray-irradiated gas in the central ∼100 pc of the Circinus galaxy
Authors: Kawamuro Taiki , Izumi Takuma , Imanishi Masatoshi 
Published: April 2019

Abstract
We report on a study of X-ray-irradiated gas in the central ∼100 pc of the Circinus galaxy, which hosts a Compton-thick active galactic nucleus (AGN), at 10 pc resolution using Chandra and ALMA. Based on ∼200 ks Chandra/ACIS-S data, we created an image of the Fe Kα line at 6.4 keV, tracing X-ray-irradiated dense gas. The ALMA data in Bands 6 (∼270 GHz) and 7 (∼350 GHz) cover five molecular lines: CO(J = 3–2), HCN(J = 3–2), HCN(J = 4–3), HCO+(J = 3–2), and HCO+(J = 4–3). The detailed spatial distribution of dense molecular gas was revealed, and compared to the iron line image. The molecular gas emission appeared faint in regions with bright iron emission. Motivated by this, we quantitatively discuss the possibility that the molecular gas is efficiently dissociated by AGN X-ray irradiation (i.e., creating an X-ray-dominated region). Based on a non-local thermodynamic equilibrium model, we constrained the molecular gas densities and found that they are as low as interpreted by X-ray dissociation. Furthermore, judging from inactive star formation reported in the literature, we suggest that the X-ray emission has the potential to suppress star formation, particularly in the proximity of the AGN.
CAR-BOREN SURVEY ON AMBIENT DOSE RATE DURING 2011–13 IN GUNMA PREFECTURE
Authors: Sugino Masato 
Published: April 2019

Abstract
A car-borne survey of air dose rate measurements was performed yearly from 2011 to 2013 to determine the levels of environmental radiation in Gunma prefecture after the Fukushima Daiichi Nuclear Power Plant accident in 2011. The results revealed that the average ambient doses in each year were 85.3 ± 34.1 nGy/h in 2011, 60.3 ± 19.9 nGy/h in 2012, and 43.5 ± 15.1 nGy/h in 2013. The ambient dose rate in 2011, which was about three times higher than the average of 27.0 ± 7.1 nGy/h in 1998, was still in safety level considering the public health, and the ambient dose rate subsequently decreased in 2013 to approximately half the 2011 level. A contour map of the ambient dose rate showed relatively higher levels in the northern and western parts of the prefecture, with relatively lower levels toward the eastern and southern parts.
Dynamic Cortical Connectivity during General Anesthesia in Healthy Volunteers
Authors: Li Duan , Vlisides Phillip E. , Kelz Max B. , Avidan Michael S. , Mashour George A. ,   for the ReCCognition Study Group
Published: April 2019

Abstract

Editor’s Perspective

What We Already Know about This Topic

What This Article Tells Us That Is New

Background
Recent studies of anesthetic-induced unconsciousness in healthy volunteers have focused on functional brain connectivity patterns, but the protocols rarely parallel the depth and duration of surgical anesthesia. Furthermore, it is unknown whether there is a single functional connectivity pattern that correlates with general anesthesia for the duration of prolonged anesthetic exposure.

Methods
The authors analyzed electroencephalographic data in 30 healthy participants who underwent induction of anesthesia with propofol followed by 3 h of isoflurane anesthesia at age-adjusted 1.3 minimum alveolar concentration. Functional connectivity was assessed by frequency-resolved weighted phase lag index between frontal and parietal channels and between prefrontal and frontal channels, which were classified into a discrete set of states through k-means cluster analysis. Temporal dynamics were evaluated by the occurrence rate and dwell time distribution for each state as well as the transition probabilities between states.

Results
Burst suppression was present, with mean suppression ratio reducing from 44.8 ± 32.3% to 14.0 ± 20.2% (mean ± SD) during isoflurane anesthesia (P < 0.001). Aside from burst suppression, eight connectivity states were classified by optimizing the reproducibility of clustering solutions, with each characterized by distinct properties. The temporal progression of dominant states revealed a successive shifting trajectory from the state associated with alpha frontal-parietal connectivity to those associated with delta and alpha prefrontal-frontal connectivity during induction, which was reversed during emergence. Cortical connectivity was dynamic during maintenance period, and it was more probable to remain in the same state (82.0 ± 8.3%) than to switch to a different state (P < 0.001). However, transitions to other states were structured, i.e., occurred more frequently than expected by chance.

Conclusions
Anesthesia-induced alterations of functional connectivity are dynamic despite the stable and prolonged administration of isoflurane, in the absence of any noxious stimuli. Changes in connectivity over time will likely yield more information as a marker or mechanism of surgical anesthesia than any single pattern.
Pediatric Risk Stratification Is Improved by Integrating Both Patient Comorbidities and Intrinsic Surgical Risk
Authors: Nasr Viviane G. , Staffa Steven J. , Zurakowski David , DiNardo James A. , Faraoni David 
Published: April 2019

Abstract

Editor’s Perspective

What We Already Know about This Topic

What This Article Tells Us That Is New

Background
Recently developed risk stratification models for perioperative mortality incorporate patient comorbidities as predictors but fail to consider the intrinsic risk of surgical procedures. In this study, the authors used the American College of Surgeons National Surgical Quality Improvement Program Pediatric database to demonstrate the relationship between the intrinsic surgical risk and 30-day mortality and develop and validate an accessible risk stratification model that includes the surgical procedures in addition to the patient comorbidities and physical status.

Methods
A retrospective analysis of the American College of Surgeons National Surgical Quality Improvement Program Pediatric database was performed. The incidence of 30-day mortality was the primary outcome. Surgical Current Procedural Terminology codes with at least 25 occurrences were included. Multivariable logistic regression model was used to determine the predictors for mortality including patient comorbidities and intrinsic surgical risk. An internal validation using bootstrap resampling, and an external validation of the model were performed.

Results
The authors analyzed 367,065 surgical cases encompassing 659 unique Current Procedural Terminology codes with an incidence of overall 30-day mortality of 0.34%. Intrinsic risk of surgical procedures represented by Current Procedural Terminology risk quartiles instead of broad categorization was significantly associated with 30-day mortality (P < 0.001). Predicted risk of 30-day mortality ranges from 0% with no comorbidities to 4.7% when all comorbidities are present among low-risk surgical procedures and from 0.07 to 46.7% among high-risk surgical procedures. Using an external validation cohort of 110,474 observations, the multivariable predictive risk model displayed good calibration and excellent discrimination with area under curve (c-index) equals 0.95 (95% CI, 0.94 to 0.96; P < 0.001).

Conclusions
Understanding and accurately estimating perioperative risk by accounting for the intrinsic risk of surgical procedures and patient comorbidities will lead to a more comprehensive discussion between patients, families, and providers and could potentially be used to conduct cost analysis and allocate resources.
Propofol Sedation Alters Perceptual and Cognitive Functions in Healthy Volunteers as Revealed by Functional Magnetic Resonance Imaging
Authors: Gross William L. , Lauer Kathryn K. , Liu Xiaolin , Roberts Christopher J. , Liu Suyan , Gollapudy Suneeta , Binder Jeffrey R. , Li Shi-Jiang , Hudetz Anthony G. 
Published: April 2019

Abstract

Editor’s Perspective

What We Already Know about This Topic

What This Article Tells Us That Is New

Background
Elucidating networks underlying conscious perception is important to understanding the mechanisms of anesthesia and consciousness. Previous studies have observed changes associated with loss of consciousness primarily using resting paradigms. The authors focused on the effects of sedation on specific cognitive systems using task-based functional magnetic resonance imaging. The authors hypothesized deepening sedation would degrade semantic more than perceptual discrimination.

Methods
Discrimination of pure tones and familiar names were studied in 13 volunteers during wakefulness and propofol sedation targeted to light and deep sedation. Contrasts highlighted specific cognitive systems: auditory/motor (tones vs. fixation), phonology (unfamiliar names vs. tones), and semantics (familiar vs. unfamiliar names), and were performed across sedation conditions, followed by region of interest analysis on representative regions.

Results
During light sedation, the spatial extent of auditory/motor activation was similar, becoming restricted to the superior temporal gyrus during deep sedation. Region of interest analysis revealed significant activation in the superior temporal gyrus during light (t [17] = 9.71, P < 0.001) and deep sedation (t [19] = 3.73, P = 0.001). Spatial extent of the phonologic contrast decreased progressively with sedation, with significant activation in the inferior frontal gyrus maintained during light sedation (t [35] = 5.17, P < 0.001), which didn’t meet criteria for significance in deep sedation (t [38] = 2.57, P = 0.014). The semantic contrast showed a similar pattern, with activation in the angular gyrus during light sedation (t [16] = 4.76, P = 0.002), which disappeared in deep sedation (t [18] = 0.35, P = 0.731).

Conclusions
Results illustrate broad impairment in cognitive cortex during sedation, with activation in primary sensory cortex beyond loss of consciousness. These results agree with clinical experience: a dose-dependent reduction of higher cognitive functions during light sedation, despite partial preservation of sensory processes through deep sedation.
Impact of the World Health Organization Surgical Safety Checklist on Patient Safety
Authors: Haugen Arvid S. , Sevdalis Nick , Søfteland Eirik 
Published: April 2019

Abstract
The incidence of surgical complications has remained largely unchanged over the past two decades. Inherent complexity in surgery, new technology possibilities, increasing age and comorbidity in patients may contribute to this. Surgical safety checklists may be used as some of the tools to prevent such complications. Use of checklists may reduce critical workload by eliminating issues that are already controlled for. The global introduction of the World Health Organization Surgical Safety Checklist aimed to improve safety in both anesthesia and surgery and to reduce complications and mortality by better teamwork, communication, and consistency of care. This review describes a literature synthesis on advantages and disadvantages in use of surgical safety checklists emphasizing checklist development, implementation, and possible clinical effects and using a theoretical framework for quality of provided healthcare (structure—process—outcome) to understand the checklists’ possible impact on patient safety.