bluuebunny/crossref_metadata_2025_split huggingface dataset:
Institutional transitions and the role of financial performance in CSR reporting
Authors: Sun Weizhang , Zhao Chunguang , Cho Charles H. 
Published: October 2018

AbstractWhile many extant studies focus on the relation between financial performance and corporate social responsibility (CSR) reporting, less attention has been given to the shifting role of financial performance in CSR reporting in a changing institutional environment. The objective of this study is to investigate whether, why, and how institutional transitions affect the role of financial performance in CSR reporting. Using samples of A‐share listed companies from 2008 to 2015, we separately examine the impacts of institutional transitions on firms' propensity to issue standalone CSR reports, the quality of voluntary CSR reports, and the quality of mandatory CSR reports. We find that financial performance buffers against external pressures brought by institutional transitions rather than only serving as a slack resource. By highlighting the buffer role of financial performance, our study provides deeper insights on the relation between financial performance and CSR reporting and contributes to extant institutional research on CSR reporting.
Genetic variation for tolerance to high temperatures in a population ofDrosophila melanogaster
Authors: Rolandi Carmen , Lighton John R. B. , de la Vega Gerardo J. , Schilman Pablo E. , Mensch Julián 
Published: October 2018

AbstractThe range of thermal tolerance is one of the main factors influencing the geographic distribution of species. Climate change projections predict increases in average and extreme temperatures over the coming decades; hence, the ability of living beings to resist these changes will depend on physiological and adaptive responses. On an evolutionary scale, changes will occur as the result of selective pressures on individual heritable differences. In this work, we studied the genetic basis of tolerance to high temperatures in the flyDrosophila melanogasterand whether this species presents sufficient genetic variability to allow expansion of its upper thermo‐tolerance limit. To do so, we used adult flies derived from a natural population belonging to theDrosophilaGenetic Reference Panel, for which genomic sequencing data are available. We characterized the phenotypic variation of the upper thermal limit in 34 lines by measuring knockdown temperature (i.e., critical thermal maximum [CTmax]) by exposing flies to a ramp of increasing temperature (0.25°C/min). Fourteen percent of the variation inCTmax is explained by the genetic variation across lines, without a significant sexual dimorphism. Through a genomewide association study, 12 single nucleotide polymorphisms associated with theCTmax were identified. In most of theseSNPs, the less frequent allele increased the upper thermal limit suggesting that this population harbors raw genetic variation capable of expanding its heat tolerance. This potential upper thermal tolerance increase has implications under the global warming scenario. Past climatic records show a very low incidence of days aboveCTmax (10 days over 25 years); however, future climate scenarios predict 243 days with extreme high temperature aboveCTmax from 2045 to 2070. Thus, in the context of the future climate warming, rising temperatures might drive the evolution of heat tolerance in this population by increasing the frequency of the alleles associated with higherCTmax.
Natal habitat conditions have carryover effects on dispersal capacity and behavior
Authors: Baines Celina B. , McCauley Shannon J. 
Published: October 2018

AbstractLocal habitat quality affects regional dynamics, including metapopulation persistence and speciation, by altering dispersal. However, most previous studies have not been able to determine whether dispersal is more strongly affected by habitat quality experienced at the dispersal stage, or carryover effects of habitat quality from previous life stages. Strong carryover effects will cause dispersal to be temporally disconnected from its drivers, altering the impact of dispersal on metapopulation dynamics, and potentially complicating empirical estimates of context‐dependent dispersal. Here, we used a fully factorial mesocosm experiment to assess how both habitat quality experienced during development and at adulthood affected emigration in adult backswimmers (Notonecta undulata). We found strong carryover effects of natal habitat quality on dispersal; individuals from high‐quality natal environments had higher emigration rates than individuals from low‐quality natal environments. However, emigration did not depend on adult habitat quality. This suggests that conditions experienced during development can outweigh the effects of habitat quality at later life stages, resulting in time lags between environmental triggers and the onset of dispersal behavior. If there are critical life stages at which dispersal rates are determined, habitat quality at those stages may have outsized impacts on biological dynamics in spatiotemporally variable landscapes.
Impact of multiple disturbances and stress on the temporal trajectories and resilience of benthic intertidal communities
Authors: Cimon Stéphanie , Cusson Mathieu 
Published: October 2018

AbstractCoastal ecosystems face severe environmental change and anthropogenic pressures that affect both the structure and functioning of communities. Understanding the response and resilience of communities that face multiple simultaneous disturbances and stresses becomes essential. We observed the recovery of a rocky intertidal subarctic macrobenthic community dominated by a macroalgal canopy (Fucus spp.), a habitat‐forming species, over a period of 14 months. Using 0.25‐m2 plots, we ran an in situ one‐pulse experiment (removal of all materials to bare rock and then burning of the surface) followed by a full orthogonal factorial design of three press‐type disturbances or stresses: grazer reduction, canopy removal, and nutrient enrichment. We evaluated the single and interactive effects of the three disturbances and stresses on species diversity and abundance structure. Of all the main effects, canopy removal has the most severe impact, resulting in decreased biomass, richness, and diversity, as well as an altered community structure. Canopy‐removed plots had fewer invertebrates and more ephemeral algae; beyond this, however, there was minimal effect from grazer reduction and nutrient enrichment acting individually. We categorized the interaction types of all significant interaction effects: Canopy removal had a dominant effect over grazer reduction on richness, and it also dominated over nutrient enrichment on diversity and evenness. Nutrient enrichment and canopy removal had a negative synergistic interaction effect on richness at the end of the experiment. Without stressors, 11 months were required to achieve full recovery. The three stressors affected recovery time differently, depending on the identity and the number of stressors. Three stressors generally increased the time of recovery or even prevented recovery from being fully attained. Moreover, community structure and composition of plots subjected to the triple‐stressor treatment had not fully recovered by the end of the study. Our results suggest that multiple stressors may interact on community indices and structure and that their interaction cannot be predicted from the outcome of single stressor studies. The inclusion of multiple disturbances and stresses in field experiments provides a better understanding of the mechanisms that shape community structure and their functioning following various forms of disturbance.
Inverse cationic ITP for separation of methadone enantiomers with sulfated β‐cyclodextrin as chiral selector
Authors: Mikkonen Saara , Caslavska Jitka , Gebauer Petr , Thormann Wolfgang 
Published: October 2018

AbstractChiral ITP of the weak base methadone using inverse cationic configurations with H+ as leading component and multiple isomer sulfated β‐CD (S‐β‐CD) as leading electrolyte (LE) additive, has been studied utilizing dynamic computer simulation, a calculation model based on steady‐state values of the ITP zones, and capillary ITP. By varying the amount of acidic S‐β‐CD in the LE composed of 3‐morpholino‐2‐hydroxypropanesulfonic acid and the chiral selector, and employing glycylglycine as terminating electrolyte (TE), inverse cationic ITP provides systems in which either both enantiomers, only the enantiomer with weaker complexation, or none of the two enantiomers form cationic ITP zones. For the configuration studied, the data reveal that only S‐methadone migrates isotachophoretically when the S‐β‐CD concentration in the LE is between about 0.484 and 1.113 mM. Under these conditions, R‐methadone migrates zone electrophoretically in the TE. An S‐β‐CD concentration between about 0.070 and 0.484 mM results in both S‐ and R‐methadone forming ITP zones. With >1.113 mM and < about 0.050 mM of S‐β‐CD in the LE both enantiomers are migrating within the TE and LE, respectively. Chiral inverse cationic ITP with acidic S‐β‐CD in the LE is demonstrated to permit selective ITP trapping and concentration of the less interacting enantiomer of a weak base.
Trader types and fleeting orders: Evidence from Taiwan Futures Exchange
Authors: Kuo Wei‐Yu , Lin Ching‐Ting 
Published: October 2018

AbstractThis paper investigates the relation between trader type and fleeting order strategy based on unique data from Taiwan Futures Exchange. We find that fleeting orders are more commonly used by institutional traders than individual traders. There exists intraday seasonality of fleeting orders submitted by institutional traders. Institutional traders do not chase market prices, but respond to changes in immediate execution costs. Network orders constitute a key component of the fleeting order strategy of proprietary traders. In sum, different types of traders, including individual traders, proprietary traders, and foreign traders, exhibit significantly different behaviors when deploying the fleeting order strategy.
Prognostic role of extracapsular spread in planned neck dissection after chemoradiotherapy
Authors: León Xavier , Pardo Laura , Sansa Aina , Fernández Alejandro , Camacho Valle , García Jacinto , López Montserrat , Quer Miquel 
Published: October 2018

AbstractBackgroundThe purpose of this study is to evaluate the prognostic significance of nodes with extracapsular spread (ECS) in patients treated with a planned neck dissection after chemoradiotherapy.MethodsWe carried out a retrospective study of 109 cN+ patients who achieved a complete response in the primary location after chemoradiotherapy and treated with a planned neck dissection.ResultsThe 5‐year disease‐specific survival for patients without residual metastatic nodes in the neck dissection (pN0, n = 69) was 75.7% (95% CI: 64.4%‐87.0%). For patients with metastatic nodes without ECS (pN+/ECS‐negative, n = 17), the corresponding figure was 74.0% (95% CI: 48.2%‐99.8%), and for patients with metastatic neck nodes with ECS (pN+/ECS‐positive, n = 23) it was 8.7% (95% CI: 0.0%‐24.3%) (P = .0001).ConclusionThe presence of ECS in the pathologic study of the planned neck dissections carried out after chemoradiotherapy in patients with human papillomavirus‐negative (HPV‐negative) head and neck squamous cell carcinoma (SCC) allows identification of a group of patients with a high risk of failure.
Spillover effects of credit default risk in the euro area and the effects on the Euro: A GVAR approach
Authors: Bettendorf Timo 
Published: October 2018

AbstractDuring the 2008 financial crisis, increasing risk and spillovers became a main concern for policy makers and banks. In addition, changes in sovereign and bank risk are believed to have had strong effects on world‐wide exchange rates. This paper aims to analyse these dynamics empirically. We estimate a Global VAR (GVAR) model for nine EMU countries plus Japan, the United Kingdom, and the United States and identify structural risk shocks using sign restrictions. Our results indicate that spillover effects of general risk are much stronger than those of bailouts. Furthermore, we demonstrate that the Euro depreciates significantly against the Yen and U.S. dollar following general risk shocks in the euro area and only to a small extent following bailout shocks. The Pound Sterling is not affected by any of these shocks. The Euro variability is, from the EMU perspective, mainly driven by shocks stemming from large countries (e.g., Germany, France, and Italy). However, shocks from third countries also play an important role.
Modelling long memory volatility in the Bitcoin market: Evidence of persistence and structural breaks
Authors: Bouri Elie , Gil‐Alana Luis A. , Gupta Rangan , Roubaud David 
Published: October 2018

AbstractMotivated by the emergence of Bitcoin as a speculative financial investment, the purpose of this paper is to examine the persistence in the level and volatility of Bitcoin price, accounting for the impact of structural breaks. Using parametric and semiparametric techniques, we find strong evidence in favour of a permanency of the shocks and lack of mean reversion in the level series. We also reveal evidence of structural changes in the dynamics of Bitcoin. After accounting for the structural breaks in the level series, evidence of mean reversion is uncovered in some cases. Further analyses show evidence of a long memory in the two measures of volatility (absolute and the squared returns), whereas some cases of short memory are revealed in the squared returns series in particular. Practical implications are discussed on the inefficiency in the Bitcoin market and its importance for Bitcoin users and investors.
Cancer of the vagina
Authors: Adams Tracey S. , Cuello Mauricio A. 
Published: October 2018

AbstractDiagnosis of a primary vaginal cancer is rare because most of these lesions will be metastatic from another primary site. Although cancer of the vagina is more common in postmenopausal women, an increase in young women being diagnosed with primary vaginal cancer has been reported, especially in countries with a high HIV prevalence. This will be associated with persistence of high‐risk HPV infection. The emphasis should be on primary prevention with prophylactic HPV vaccination. Once there is a suspicion of a primary vaginal cancer, this should be confirmed histologically with biopsy. Staging has been done clinically, similar to cervical cancer; however, there is a role for imaging in assisting with staging as this is often a difficult assessment. Treatment should be individualized and depends on stage as well as histologic subtype. It is prudent to refer cases to centers of excellence with experience in dealing with this rare gynecological cancer.
Biohybrids of scaffolding hyaluronic acid biomaterials plus adipose stem cells home local neural stem and endothelial cells: Implications for reconstruction of brain lesions after stroke
Authors: Sanchez‐Rojas Leyre , Gómez‐Pinedo Ulises , Benito‐Martin María Soledad , León‐Espinosa Gonzalo , Rascón‐Ramirez Fernando , Lendinez Cristina , Martínez‐Ramos Cristina , Matías‐Guiu Jorge , Pradas Manuel Monleón , Barcia Juan A. 
Published: October 2018

AbstractEndogenous neurogenesis in stroke is insufficient to replace the lost brain tissue, largely due to the lack of a proper biological structure to let new cells dwell in the damaged area. We hypothesized that scaffolds made of hyaluronic acid (HA) biomaterials (BM) could provide a suitable environment to home not only new neurons, but also vessels, glia and neurofilaments. Further, the addition of exogenous cells, such as adipose stem cells (ASC) could increase this effect. Athymic mice were randomly assigned to a one of four group: stroke alone, stroke and implantation of BM, stroke and implantation of BM with ASC, and sham operated animals. Stroke model consisted of middle cerebral artery thrombosis with FeCl3. After 30 days, animals underwent magnetic resonance imaging (MRI) and were sacrificed. Proliferation and neurogenesis increased at the subventricular zone ipsilateral to the ventricle and neuroblasts, glial, and endothelial cells forming capillaries were seen inside the BM. Those effects increased when ASC were added, while there was less inflammatory reaction. Three‐dimensional scaffolds made of HA are able to home newly formed neurons, glia, and endothelial cells permitting the growth neurofilaments inside them. The addition of ASC increase these effects and decrease the inflammatory reaction to the implant. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1598–1606, 2019.
ZC3H13 suppresses colorectal cancer proliferation and invasion via inactivating Ras–ERK signaling
Authors: Zhu Dehua , Zhou Jianping , Zhao Jinbo , Jiang Guiyang , Zhang Xiupeng , Zhang Yong , Dong Ming 
Published: October 2018

AbstractZC3H13 is a canonical CCCH zinc finger protein, which harbors a somatic frame‐shift mutation in colorectal cancer (CRC). However, its expression and biological function were still uncertain. In the current study, we found that ZC3H13 was served as a tumor suppressor in CRC cells, which decreased the expression of Snail, Cyclin D1, and Cyclin E1, and increased the expression of Occludin and Zo‐1 through inactivating Ras–ERK signaling pathway. Furthermore, reduction of ZC3H13 associated with advanced TNM stage (p = 0.02), positive regional lymph node metastasis (
p = 0.01). Taken together, the current study indicated that ZC3H13 may be an upstream regulator of Ras–ERK signaling pathway and suppressed invasion and proliferation of CRC.
Assessing a Micro and Small Businesses Innovation Support Programme in Brazil: The Local Innovation Agents Programme
Authors: de Carvalho Gustavo Dambiski Gomes , de Carvalho Hélio Gomes , Cardoso Hugo Henrique Roth , Gonçalves Adriana Dantas 
Published: October 2018

AbstractCreated by the Brazilian Micro and Small Business Support Service (SEBRAE) and developed in partnership with the National Council for Scientific and Technological Development (CNPq), the local innovation agents (LIA) programme aims to convey innovation to Brazilian micro and small businesses (MSBs) and has covered around 150 000 MSBs since 2008. Notwithstanding, assessments of the LIA programme are still limited. Therefore, this paper aims to assess the impact of the LIA programme based on a sample of over 6000 MSBs. Results show that all dimensions improved to some extent, but marketing and organizational‐related innovations improved more than product and process‐related ones. © 2018 John Wiley & Sons, Ltd.
El Niño–Southern Oscillation related teleconnections over South America under distinct Atlantic Multidecadal Oscillation and Pacific Interdecadal Oscillation backgrounds: La Niña
Authors: Kayano Mary Toshie , Andreoli Rita Valéria , Souza Rodrigo Augusto Ferreira de 
Published: October 2018

The Pacific Interdecadal Oscillation (PDO) and the Atlantic Multidecadal Oscillation (AMO) influence in different ways the La Niña (LN) related teleconnections in South America. The low‐frequency backgrounds in the Atlantic and Pacific Oceans play an important role in modulating the LN‐related Walker and Hadley cells and the Rossby wavetrain pattern in the Southern Hemisphere. The illustration shows the LN‐related SST anomaly pattern during the austral summer for distinct low‐frequency backgrounds.This analysis investigates the concomitant influence of two dominant low‐frequency modes, the Pacific Interdecadal Oscillation (PDO) and the Atlantic Multidecadal Oscillation (AMO), on the La Niña (LN) related climate teleconnections over South America (SA). Four possible low‐frequency backgrounds are analysed: WAMO/WPDO, WAMO/CPDO, CAMO/WPDO and CAMO/CPDO, with the letters “W” and “C” referring, respectively, to the warm and cold phases of the AMO and PDO. The low‐frequency anomalous sea surface cooling (warming) in the tropical Pacific during the CPDO (WPDO) favours (impedes) the settling of the LN‐related negative SST anomalies in this oceanic sector. Thus, the LN‐related SST anomaly patterns in the tropical Pacific in the CPDO backgrounds are meridionally more extensive and stronger than those in the WPDO backgrounds. The highest and lowest percentages of the years that experienced LN events occurred during the WAMO/CPDO and CAMO/WPDO backgrounds, respectively. The northern node of the LN‐related wet–dry dipole between northern SA and southeastern SA (SESA) occurs in most seasons for all backgrounds. However, the southern node occurs in specific seasons: spring and summer for the WAMO/WPDO, winter and spring for the WAMO/CPDO, winter and summer for the CAMO/WPDO and spring for the CAMO/CPDO. Also, the LN effect on the South American monsoon with a wet–dry dipole between northern SA and eastern Brazil during summer is noted in most backgrounds, but with differences among them. We discuss here the differences in the precipitation anomaly patterns, Walker and Hadley cells and Rossby wavetrain patterns among the backgrounds. The low‐frequency Atlantic and Pacific backgrounds play an important role in defining the rainfall anomaly pattern associated with the LN. The results shown here have not been discussed before and might be useful mainly for climate monitoring purposes.
Impacts of April snow cover extent over Tibetan Plateau and the central Eurasia on Indian Ocean Dipole
Authors: Yuan Chaoxia , Li Wenjie , Guan Zhaoyong , Yamagata Toshio 
Published: October 2018

It has been widely accepted that the Indian Ocean Dipole (IOD) can influence the global climate and thus improvement of its understanding is beneficial to our society. In this study, we show that the April snow cover extents (SCEs) over Tibetan Plateau and the central Eurasia may play an important role on triggering the occurrence of IOD. The correlation coefficient between the April SCE indices and the subsequent September–November dipole mode indices is −0.51 in the recent 40 years, significant at the 99% confidence level. In years with the larger April SCEs, the thermally driven ascending over the plateau becomes weaker and causes anomalous subsidence over the plateau and its southern contiguous region. This, together with the cooler‐than‐normal continent, can delay the onset of Bay of Bengal (BOB) summer monsoon. As a result, the northwards migration of the major rainbelt from the eastern tropical Indian Ocean to the eastern BOB in accordance with the monsoon onset will be delayed, leading to increased precipitation in the eastern tropical Indian Ocean. The increased precipitation may lead to generation of the negative IOD through the local air–sea interactions.The observed April SCEs–IOD relation has been examined in historical runs of 19 coupled models participating phase 5 of the Coupled Model Intercomparison Project (CMIP5). Most models except MRI‐CGCM3 fail to reproduce the observed April SCEs–IOD relationship. This is probably due to their difficulties in realistically simulating the snow impacts on the BOB summer monsoon and the air–sea coupling during the IOD development.
Tri‐icosahedral Au37 cluster as a carrier/detector for anti‐cancer cisplatin drug
Authors: Palacios‐Álvarez Omar , Tlahuice‐Flores Alfredo 
Published: October 2018

AbstractIn this work, DFT studies devoted to the adsorption of anti‐cancer cisplatin drug and one cationic tri‐icosahedral Au37 cluster are addressed, which are aiming to explore the application of thiolate/phosphine protected gold clusters as carriers/detectors for cisplatin molecules. The Au37 cluster is able to adsorb up to four cisplatin molecules, and the cisplatin4/Au37 complex holds a 1.71 eV adsorption energy value. Further atomic population analysis reveals that adsorbed cisplatin molecules bear major partial charges, attesting an asymmetric distribution of electrons into their bonds. Vibrational assignments of two enhanced IR and Raman signals (circa the 200‐fold boost) disclose the coupling of some normal modes of the cisplatin dimer with the Au37 cluster, making this cluster able to detect small concentrations of cisplatin molecules.