bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rates of complications amongst peripherally inserted central catheters in paediatric populations: a systematic review and meta-analysis
Authors: Deshwal Avinash , Duffy Michael , Mac Curtain Benjamin , Mahmood Hassan , Mc Manus Ethel , Deshwal Abhinav 
Published: November 2024

Abstract
Background
Peripherally inserted central catheters have become a mainstay of treatment for a broad range of indications in both adult and paediatric populations. Despite their broad range of applications there has been an overall lack of analysis of the rates of complications associated with their use in paediatric populations.

Objectives
We conducted a systematic review and meta-analysis to estimate the rate of PICC associated complications in paediatric populations excluding neonates.

Method
We searched published literature for records discussing PICC use in paediatric populations. Statistical analysis was performed using Stata 17. We calculated pooled estimates using a 95% confidence interval using a random effects model and heterogeneity was assessed using I2.

Results
Of the 3689 participants there was a pooled complication rate of 6% (95% CI 5–6%; I2 = 0). Rates of infections were estimated at 3% (95% CI 3–4%; I2 = 0), thromboembolic complications at 1% (95% CI 0–1%; I2 = 0), mechanical failures were estimated at 8% (95% CI 7–9%; I2 = 0) and superficial thrombophlebitis at 1% (95% CI 0–1%; I2 = 0).

Conclusion and contribution
Our findings indicate that complications associated with PICC use in paediatric populations are broadly similar to those observed in the general population, with a notably lower incidence of thrombosis. We aim to add to the growing body of literature in this area and hope to improve the overall surveillance and knowledge of PICC related complications in paediatric populations.
Investigating Associations Between Climate Change Anxiety and Children’s Mental Health in Pakistan: Impacts and Priority Actions
Authors: Soomro Shazia , Zhou Dianen , Charan Iftikhar Ahmed 
Published: November 2024

AbstractObjectivesClimate anxiety has a negative impact on the mental health and psychological wellbeing of the vulnerable population. The goal is to assess many factors that affect mental health and psychological wellbeing, as well as how climate change affects mental health in Pakistan’s vulnerable population.MethodsThis study provides evidence-based insights on the long- and medium-term impacts of extreme weather events on mental health. To obtain information on these variables, this research uses a quantitative approach and a cross-sectional survey design with a multivariate regression model for empirical tests on a sample of parents and children with an impact on mental health from climate change anxiety.ResultsResults indicate that individuals experience shock and climate change anxiety, and their effects on mental health and psychological wellbeing. Climate change can have detrimental effects on children’s mental health. (1) disaster risk health (2) children’s stress index (3) public health concerns, (4) climate change anxiety, (5) generalized anxiety disorder, and (6) major depression disorder, as reported by the children with mental health outcomes.ConclusionsThe findings of this study show that climate change has a stressful effect on mental health. The paper concludes with a discussion on strategies to address the anticipated mental health issues among children due to climate change.
Network meta-analysis of the effectiveness of psychotherapies with or without medication for treating adult depression
Authors: Fukumori Mayumi , Kikuchi Toshiaki , Zhou Yi , Hattori Satoshi , Kudo Takashi 
Published: November 2024

AbstractObjective:To ascertain whether psychotherapies combined with medication are more efficacious than those without medication and determine which combinations yield the best results.Methods:We conducted a network meta-analysis of randomised controlled trials (RCTs) comparing behavioural activation (BA), psychoanalytic/psychodynamic psychotherapy (DYN), interpersonal psychotherapy (IPT), individual face-to-face cognitive behavioural therapy (CBT (ftf)), group cognitive behavioural therapy (gCBT), and computerised or internet cognitive behavioural therapy (iCBT) with each other, or with treatment-as-usual (TAU) and wait list control (WLC) among adults formally diagnosed with depression. The psychotherapy arms were categorised as either psychotherapy alone or psychotherapy combined with medication (+ p). Treatment efficacy was assessed based on depression severity. We used a random-effects model to conduct a pairwise meta-analysis.Results:A total of 100 RCTs with 9,873 participants were included. The most common treatment was CBT (ftf) alone. All treatment arms were compared with TAU. Most psychotherapies combined with medication were superior to psychotherapy alone. In the subgroup analyses according to the baseline severity of depression, most psychotherapies combined with medication were more effective than psychotherapy alone in moderate-to-severe depression, whereas in mild depression, such differences were not observed. Among psychotherapies with medication, gCBT + p was significantly more effective than TAU and other psychotherapies in both the main and subgroup analyses.Conclusion:The efficacy of depression treatment varied depending on the severity of the depressive condition. Notably, gCBT + p was identified as the most effective approach for treating adult depression.
“We Were the Army in the Shadows”: The Dynamics of Military Rule and Experiences of Black Women in the South African Defence Force 32 Battalion Military Community
Authors: Bolliger Lennart , Raber Richard Levi , Estevao Dino 
Published: November 2024

AbstractIn this article, we demystify the South African Defence Force’s 32 Battalion and de-exceptionalize the apartheid military by connecting it to other colonial military communities, and apartheid governance more broadly. Drawing on oral history, autoethnography, and archival documents, we demonstrate the highly unequal, yet mutual, reliance of white authorities and elite Black women in the haphazard and improvised nature of apartheid military rule. Most women arrived at the unit's base, Buffalo, as Angolan refugees, where white military authorities fixated on their domestic and family lives. We examine the practical workings of military rule by considering three nodes of social surveillance and control. Elite Black women, known as “block leaders,” served as intermediaries, actively participating in the mechanics of military rule while also using their position to advocate for their community. Finally, we consider the ingrained violent patriarchal nature of life in the community by highlighting the nature of women's precariousness and labor.
Fipronil prevents transmission of Lyme disease spirochetes
Authors: Šíma Radek , Palusová Adéla , Hatalová Tereza , Robbertse Luise , Berková Petra , Moos Martin , Kopáček Petr , Urbanová Veronika , Perner Jan 
Published: November 2024

AbstractLyme disease, a tick-borne illness caused by Borrelia spirochetes, poses a significant threat to public health. While acaricides effectively control ticks on pets and livestock, their impact on pathogen transmission is often unclear. This study investigated the acaricidal efficacy of fipronil against Ixodes ricinus ticks and its potential to block Borrelia afzelii transmission. Initially, we employed the ex vivo membrane blood-feeding system to assess the dose–response acaricidal activity of ivermectin, fipronil and its metabolite fipronil sulfone, when supplemented in the blood meal throughout tick feeding. To obtain the temporal resolution of their acaricidal activity, ticks were allowed to initiate blood feeding on an artificial membrane before being exposed to a 1-time topical application of these acaricides. Fipronil demonstrated superior speed of acaricidal activity, with onset of tick moribundity within a few hours, prompting its selection for further in vivo testing with Borrelia-infected ticks. The I. ricinus nymphs infected with B. afzelii were topically treated with fipronil shortly after attachment to mice. Four weeks post-feeding, the skin and internal organs were examined for the presence of Borrelia. No spirochetes were detected in any organ of mice exposed to fipronil-treated ticks, while 9 out of 10 control mice, exposed to non-treated infectious ticks, displayed Borrelia infection. The in vitro co-culture experiments confirmed that fipronil had no direct effect on Borrelia viability, indicating a tick-directed effect. Overall, these results underline the potential of fipronil as a valuable tool for tick control strategies and suggest a concept for acaricide-mediated Borrelia-transmission blockers.
Isopods infesting Atlantic bonefish (Albula vulpes) host novel viruses, including reoviruses related to global pathogens, and opportunistically feed on humans
Authors: Goldberg Tony L. , Perez Addiel U. , Campbell Lewis J. 
Published: November 2024

Abstract
Isopods infest fish worldwide, but their role as disease vectors remains poorly understood. Here, we describe infestation of Atlantic bonefish (Albula vulpes) in Belize with isopods in two of three locations studied, with infestation rates of 15 and 44%. Isopods fed aggressively, and infested fish showed missing scales and scars. Gross morphologic and molecular phylogenetic analyses revealed the isopods to cluster within the family Aegidae and to be most closely related to members of the genus Rocinela, which are globally distributed micro-predators of fish. Metagenomic analysis of 10 isopods identified 11 viruses, including two novel reoviruses (Reovirales) in the families Sedoreoviridae and Spinareoviridae. The novel sedoreovirus clustered phylogenetically within an invertebrate-specific clade of viruses related to the genus Orbivirus, which contains arboviruses of global concern for mammal health. The novel spinareovirus clustered within the fish-infecting genus Aquareovirus, which contains viruses of global concern for fish health. Metagenomic analyses revealed no evidence of infection of bonefish with the novel aquareovirus, suggesting that viremia in bonefish is absent, low, or transient, or that isopods may have acquired the virus from other fish. During field collections, isopods aggressively bit humans, and blood meal analysis confirmed that isopods had fed on bonefish, other fish, and humans. Vector-borne transmission may be an underappreciated mechanism for aquareovirus transmission and for virus host switching between fish and other species, which has been inferred across viral families from studies of deep virus evolution.
Phenotypic plasticity and insect herbivory of trees in contrasting light environments in a Mexican rainforest
Authors: Cadena-Zamudio Daniel A. , Guevara Roger , Ruiz-Guerra Betsabé 
Published: November 2024

Abstract
Contrasting light environments in rainforests generates changes in the characteristics of the leaves and in the herbivore community. In the present study, we carried out a reciprocal transplant experiment under natural conditions to determine the plasticity of leaf characteristics of plant species that grow in contrasting light environments in a Neotropical forest. We further explored the relationship between these traits and insect herbivory. We found that six woody species differ markedly in the phenotypic plasticity of leaf features. The specific leaf area, chlorophyll content, carbon content, nitrogen content, and leaf thickness of the most light-demanding species were highest in gaps, but their carbon/nitrogen ratios were higher under closed canopies. The herbivores were more abundant in gaps (5.9%–14.8%) than under closed canopy habitats (3.4%–6.1%) and seemingly associated to the plasticity of the leaf traits. We observed 47% more herbivores in gaps than under closed canopies. Our results suggest that the phenotypic plasticity of leaf traits depends on the identity of the plant species and its wood density, while herbivory seems to be affected by plant defence, low nutritional quality, or herbivore tolerance.
Identifying risk factors for clinical Lassa fever in Sierra Leone, 2019–2021
Authors: Sama Daniel Juma , Haider Najmul , Guitian Javier , Osman Abdinasir Yusuf , Ntoumi Francine , Zumla Alimuddin , Kock Richard , Ansumana Rashid 
Published: November 2024

Abstract
Lassa fever (LF) virus (LASV) is endemic in Sierra Leone (SL) and poses a significant public health threat to the region; however, no risk factors for clinical LF have been reported in SL. The objective of this study was to identify the risk factors for clinical LF in an endemic community in SL. We conducted a case–control study by enrolling 37 laboratory-confirmed LF cases identified through the national LF surveillance system in SL and 140 controls resided within a one-kilometre radius of the case household. We performed a conditional multiple logistic regression analysis to identify the risk factors for clinical LF. Of the 37 cases enrolled, 23 died (62% case fatality rate). Cases were younger than controls (19.5 years vs 28.9 years, p < 0.05) and more frequently female (64.8% vs 52.8%). Compared to the controls, clinical LF cases had higher contact with rodents (rats or mice) in their households in the preceding three weeks (83.8% vs 47.8%). Households with a cat reported a lower presence of rodents (73% vs 38%, p < 0.01) and contributed to a lower rate of clinical LF (48.6% vs 55.7%) although not statistically significant (p = 0.56). The presence of rodents in the households (matched adjusted odds ratio (mAOR): 11.1) and younger age (mAOR: 0.99) were independently associated with clinical LF.
Rodent access to households and younger age were independently associated with clinical LF. Rodent access to households is likely a key risk factor for clinical LF in rural SL and potentially in other countries within the West African region. Implementing measures to control rodents and their access to households could potentially decrease the number of clinical LF cases in rural SL and West Africa.
Absolute Fairness and Weighted Lotteries
Authors: Tank Lukas , Wendler Nils , Carstensen-Mainka Jan Peter 
Published: November 2024

AbstractWeighted lottery proposals give guidance in rescue dilemma situations by balancing the demands of comparative and absolute fairness. While they do not advocate for saving the greater number outright, they are responsive to absolute fairness insofar as they show a certain sensitivity to the numbers involved. In this paper we investigate what criterion of absolute fairness we should demand weighted lotteries to fulfill. We do so by way of critically examining what is probably the most sophisticated weighted lottery on the market: Gerard Vong's Exclusive Composition-Sensitive (EXCS) lottery. We find that both the standard that seems most common in the debate, and a different standard Vong uses to criticize Jens Timmermann's Individualist Lottery are in contradiction to basic demands placed upon weighted lotteries and are therefore unsuitable as necessary conditions for absolute fairness. We instead propose a purely gradual understanding of absolute fairness.
Effects of esketamine combined with dexmedetomidine on postoperative delirium and quality of recovery in elderly patients undergoing thoracoscopic radical lung cancer surgery: a randomized controlled trial
Authors: Zhang Cong-Li , Yan Yan , Zhang Yang , Bai Han-Lin , Zhuang Qin , Song Nan-Nan , Feng Chuan-Jiang , Xie Li-Juan , Wang Si-Yi , Li Xiao-Hong , Liu Di , Ren Li 
Published: November 2024

AbstractObjectiveThis study aimed to investigate the effects of esketamine (Esk) combined with dexmedetomidine (Dex) on postoperative delirium (POD) and quality of recovery (QoR) in elderly patients undergoing thoracoscopic radical lung cancer surgery.MethodsIn this prospective, randomized, and controlled study, 172 elderly patients undergoing thoracoscopic radical lung cancer surgery were divided into two groups: the Esk + Dex group (n = 86) and the Dex group a (n = 86). The primary outcome was the incidence of POD within 7 days after surgery and the overall Quality of Recovery−15 (QoR − 15) scores within 3 days after surgery. Secondary outcomes included postoperative adverse reactions, extubation time, PACU stay, and hospitalization time. Serum levels of IL-6, IL-10, S100β protein, NSE, CD3+, CD4+, and CD8+ were detected from T0 to T5.ResultsCompared with the Dex group, the incidence of POD in the Esk + Dex group was significantly lower at 7 days after surgery (14.6% vs 30.9%; P = 0.013). The QoR − 15 score was significantly increased 3 days after surgery (P < 0.01). Levels of IL-6 and CD8+ were significantly decreased, and IL − 10 levels were significantly increased at T1-T2 (P < 0.05). At T1-T4, NSE levels were significantly decreased, while CD3+ and CD4+/CD8+ values were significantly increased (P < 0.01). At T1-T5, serum S100β protein concentration decreased significantly, and CD4+ value increased significantly (P < 0.01). The incidence of nausea/vomiting and hyperalgesia decreased significantly 48 hours after surgery (P < 0.01). The duration of extubation, PACU stay, and postoperative hospitalization were significantly shortened.ConclusionsEsketamine combined with dexmedetomidine can significantly reduce the POD incidence and improve the QoR in patients undergoing thoracoscopic radical lung cancer surgery, which may be related to the improvement of cellular immune function.
External validation of the OAC3-PAD risk score after endovascular revascularisation
Authors: Pelicon Kevin , Petek Klemen , Boc Anja , Kejžar Nataša , Blinc Aleš , Boc Vinko 
Published: November 2024

Summary: Background: The OAC3-PAD bleeding risk score was developed to assess the bleeding risk in patients with peripheral arterial disease (PAD), however its performance in patients treated exclusively with endovascular revascularisation has not yet been tested. We aimed to externally validate the bleeding risk score for this patient cohort. Patients and methods: A retrospective observational study, analysing the data of all PAD patients successfully treated with endovascular revascularisation in a single centre within a five-year period. The performance of the Cox proportional hazards (CPH) model, upon which the OAC3-PAD bleeding risk score is based, was tested using calibration methods, discrimination, and a scaled Brier score for overall performance. The OAC3-PAD bleeding risk score was calculated for all patients, classifying them into the four respective risk groups. Kaplan-Meier curves were plotted for all risk groups and discrimination was tested using log-rank tests. Results: While discrimination of the CPH model was adequate, calibration of the model was poor and the scaled Brier score was 3.27% (95% CI 0.65%–4.40%). Of the 1,434 patients, 33 (2.3%) experienced a major bleeding event. The frequency of bleeding was 0.4% in the low risk group (3/736 patients), 0.8% in the low-to-moderate risk group (2/243 patients), 5.8% in the moderate-to-high risk group (15/258 patients), and 6.6% in the high risk group (13/197 patients). The OAC3-PAD score successfully discriminated each of the two lower bleeding risk groups from one of the two higher risk groups, but failed to discriminate among the two lower risk groups and the two higher risk groups, respectively. Conclusions: Although the OAC3-PAD score did not stratify patients into the four respective risk groups, it allowed discrimination between the low risk patients and the high risk patients. It could therefore become a useful tool for predicting major bleeding events in patients with PAD after endovascular revascularisation.
The Enigmatic Pockmarks of the Sandy Southeastern North Sea
Authors: Böttner Christoph , Hoffmann Jasper J. L. , Unverricht Daniel , Schmidt Mark , Spiegel Timo , Geersen Jacob , Müller Thomas Harald , Karstens Jens , Andresen Katrine Juul , Sander Lasse , Schneider von Deimling Jens , Schmidt Christopher 
Published: November 2024

AbstractNatural seafloor depressions, known as pockmarks, are common subaqueous geomorphological features found from the deep ocean trenches to shallow lakes. Pockmarks can form rapidly or over millions of years and have a large variety of shapes created and maintained by a large variety of mechanisms. In the sandy sediments of the southeastern North Sea, abundant shallow pockmarks are ubiquitous and occur at shallow water depths (<50 m). Their formation has previously been linked to methane seepage from the seafloor. Here, we characterize over 50,000 pockmarks based on their morphology, geochemical signature, and the subsurface pre‐conditions using a new integrated geoscientific data set, combining geophysical and sedimentological data with geochemical porewater and oceanographic analysis. We test whether the methane seepage is indeed responsible for pockmark formation. However, our data suggest that neither the seepage of light hydrocarbons nor groundwater is driving pockmark formation. Because of this lack of evidence for fluid seepage, we favor the previously suggested biotic formation but also discuss positive feedback mechanisms in ocean bottom currents as a formation process. Based on a comparison of pockmarks to the central and southeastern North Sea, we find that local lithology significantly affects pockmark morphology. Muddy lithologies favor the formation of larger, long‐lived structures, while sandy lithologies lead to short‐lived, small‐scale structures that are large in area but with shallow incision depth. We conclude that pockmarks in sandy environments might have been overlooked globally due to their shallow incision depth and recommend reevaluating the role of hydrocarbon ebullition in pockmark formation.
Air‐Sea Heat and Moisture Flux Gradients
Authors: Parfitt Rhys 
Published: November 2024

AbstractAir‐sea heat and moisture fluxes modulate the surface energy balance and oceanic and atmospheric heat transport across all timescales. Spatial gradients of these fluxes, on a multitude of spatial scales, also have significant impacts on the ocean and atmosphere. Nevertheless, analysis of these gradients, and discussion regarding our ability to represent them, is relatively absent within the community. This letter discusses their importance and presents a wintertime climatology. Their sensitivity to spatiotemporal scale and choice of data set is also examined in the mid‐latitudes. A lead‐lag analysis illustrates that wintertime air‐sea heat flux gradients in the Gulf Stream can precede the North Atlantic Oscillation by ∼1 month. A lack of observations and thus validation of air‐sea heat flux gradients represents a significant gap in our understanding of how air‐sea processes affect weather and climate, and warrants increased attention from the observational and modeling communities.