bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting subcellular localization of multisite proteins using differently weighted multi-label k-nearest neighbors sets
Authors: Jiang Zhongting , Wang Dong , Wu Peng , Chen Yuehui , Shang Huijie , Wang Luyao , Xie Huichun 
Published: April 2019

BACKGROUND: For a protein to execute its function, ensuring its correct subcellular localization is essential. In addition to biological experiments, bioinformatics is widely used to predict and determine the subcellular localization of proteins. However, single-feature extraction methods cannot effectively handle the huge amount of data and multisite localization of proteins. Thus, we developed a pseudo amino acid composition (PseAAC) method and an entropy density technique to extract feature fusion information from subcellular multisite proteins. OBJECTIVE: Predicting multiplex protein subcellular localization and achieve high prediction accuracy. METHOD: To improve the efficiency of predicting multiplex protein subcellular localization, we used the multi-label k-nearest neighbors algorithm and assigned different weights to various attributes. The method was evaluated using several performance metrics with a dataset consisting of protein sequences with single-site and multisite subcellular localizations. RESULTS: Evaluation experiments showed that the proposed method significantly improves the optimal overall accuracy rate of multiplex protein subcellular localization. CONCLUSION: This method can help to more comprehensively predict protein subcellular localization toward better understanding protein function, thereby bridging the gap between theory and application toward improved identification and monitoring of drug targets.
A three-dimensional finite element analysis of the effect of archwire characteristics on the self-ligating orthodontic tooth movement of the canine
Authors: Cai Yongqing 
Published: April 2019

BACKGROUND: In orthodontics, the tooth movement is a biologic reaction to applied force systems, brackets, archwires, and periodontium tissue. OBJECTIVE: To investigate the effects of the various archwire characteristics like the friction coebetween bracket and archwire, the cross-section shape, and the cross-section dimension, on the displacement and the periodontal ligament (PDL) stresses of canine’s movement in a self-ligating treatment using the finite element (FE) analysis method. METHODS: Models of teeth and their supporting tissues, brackets and archwires were constructed. Ten kinds of archwires were used for the simulation. RESULTS: Considering the translation movement, the maximum displacement, highest stress, and [Formula: see text] increased with an increase in the cross-section area. The maximum displacement and highest stress increased with an increase in the friction coefficient. The [Formula: see text] values increased with an increase in the friction coefficient in the round archwires, while decreased with an increase in the rectangular archwires. However, these change tends were different in rotation and inclination movement. CONCLUSION: The archwire characteristics (round archwire, rectangular archwire, cross-section area, and friction coefficient) exhibited different effects on the tooth translation, rotation, and inclination. Our results can assist in the improvement of the self-ligating orthodontic treatment.
Study on the prediction of the contamination symptoms in the fermentation process of Chlortetracycline based on soft sensor modeling method
Authors: Sun Yumei , Tang Lingtong , Sun Qiaoyan , Wang Meichun , Han Xiang , Chen Xiangguang 
Published: April 2019

BACKGROUND: How to accurately predict the occurrence of contamination in the fermentation process of Chlortetracycline? How to prompt field operators to take effective measures in time? This is a difficult problem that the fermentation process of Chlortetracycline has not been solved well. OBJECTIVE: The aim of this paper is to effectively predict whether the fermentation process of Chlortetracycline is contaminated or not. METHODS: A Gaussian process regression soft sensor modeling method with real time integration learning is studied in depth by combining two local learning strategies, namely just-in-time learning (JITL) method and integrated learning method, and a multi-model weighted Gaussian process regression (MWGPR) soft sensor modeling method based on real-time integration learning is proposed in the paper. This soft sensing method was used to study the relationship between the viscosity of fermentation broth and the contamination in fermentation process. A soft-sensing model based on the viscosity of fermentation broth for predicting the signs of contamination is established. RESULTS: The validity of this method is verified by field data. The experimental results demonstrate that the soft sensing model proposed in this paper can effectively determine whether the fermentation broth is infected by hybrid bacteria. CONCLUSIONS: The method proposed in this paper is innovative and practical so that field operators can issue early warning and take effective measures.
Experimental study on healthy volunteers based on magnetic induction brain edema monitoring system
Authors: Xu Jia , Li Gen , Zhao Shuanglin , Chen Mingsheng , Chen Jingbo , Xu Lin , Wang Feng , Bai Zelin , Qin Mingxin , Sun Jian 
Published: April 2019

BACKGROUND: Cerebral edema is a common secondary disease after stroke. It is very important to realize real-time continuous monitoring of cerebral edema for stroke patients. OBJECTIVE: A non-contact magnetic induction phase shift (MIPS) detection system is used to monitor the change of global brain electrical conductivity during cerebral edema. METHODS: In order to verify the feasibility of this system monitoring, we carry out salt solution simulation experiments and healthy people breath holding experiments. As a comparison of later clinical experiments, 13 young healthy volunteers aged 22–35 are selected for this study to carry out a 10 minute/time monitoring experiment. RESULTS: It is found that the MIPS values measured by the salt solution of edema and the salt solution of bleeding are significantly different. The results show that the MIPS value of healthy young people is in a stable state with an MIPS mean value of 1.106 ([Formula: see text] 0.736)[Formula: see text]. Compare it with the monitoring results of a cerebral edema patient. The MIPS of patient fluctuates greatly, and the changes of MIPS and intracranial pressure show consistent trend at the peak of the edema period. CONCLUSIONS: We preliminarily verify that the system can be used for cerebral edema monitoring.
Lower extremity kinematics during forward heel-slip
Authors: Kim Sukwon , Joo Kyung-Sook , Liu Jian , Sohn Jee-Hoon 
Published: April 2019

BACKGROUND: Most fall intervention studies attempted to improve the mobility, range of motion of upper and lower extremities, or all major muscle strengths. Yet, there has been little effort to identify movements or actions that may be mainly responsible for recovering from a slipping. It was imperative to link lower extremity kinematics in conjunction with the functional anatomy of lower extremity muscles during forward heel-slipping to identify what muscles should have been activated substantially if a person would have recovered from forward heel-slipping. OBJECTIVE: The present study investigated lower extremity movements, such as the ankle, knee, and hip rotations, which could contribute to falls from forward heel-slipping. Determining changes in positions of foot, shank, and thigh during slipping would provide information to develop the optimal training regimen or interventions that may be effective for improving a chance to recover from the postural disturbance. METHODS: Twenty healthy adults (24–68 years old) participated in this experiment. Among twenty participants, only eight participants’ data were analyzed in this study. The 3D position data were used to compute the sagittal foot, shank, and thigh angles and frontal thigh angle. RESULTS: The study results indicated that, during the period of slipping, the angles of the segments of the slipping leg were different from that of the foot, shank, and thigh when walking ordinarily over the dry surface in the present study. CONCLUSIONS: The characteristics or differences in the angular kinematics of lower extremity during unexpected slips in the present study demonstrate possible causes for slip-induced falls.
Study on the mechanism of TMRK electroacupuncture in repairing synaptic plasticity in amygdala and hippocampus to relieve fear memory in PTSD rats
Authors: Li Mi , Li Kai , Zhang Hong , Jiang Yong 
Published: April 2019

BACKGROUND AND OBJECTIVE: Post-traumatic stress disorder (PTSD) is a chronic mental disorder caused by mental or psychological trauma after sudden events of a catastrophic or threatening nature. Synaptic plasticity is the core mechanism of PTSD and the main point of treatment of this disease. METHODS: Male Sprague Dawley rats were randomly divided into blank control (Ctrl), SPS (single-prolonged stress) model, SPS&S model (SPS and foot electric shock), SPS+EA (SPS plus electroacupuncture), and SPS&S+EA groups. Tranquilize Mind and Regulate Kidney (TMRK) electroacupuncture method was performed in each rat in the SPS+EA and SPS&S+EA groups, the treatment lasted for 20 minutes per day, simultaneously for 3 consecutive weeks. Behavioral evaluations, molecular tests, electron microscopy, electrophysiological testing were conducted following the treatment. RESULTS: First, electro-acupuncture can significantly improve the PTSD-like symptoms. Second, electro-acupuncture can up-regulate the long-term potentiation (LTP) in hippocampus, repair the synaptic morphology and improve BDNF levels in amygdala and hippocampus. Third, electroacupuncture can significantly up-regulate SYN, GAP43, and PSD95 protein levels and mRNA expression in amygdala and hippocampus. CONCLUSIONS: The effect of TMRK electro-acupuncture method on the regression of fear memory of PTSD rats may be through its repair of synaptic plasticity in amygdala and hippocampus.
STRATEGI PENGEMBANGAN EKOWISATA KARST DI DUSUN RAMMANG-RAMMANG KABUPATEN MAROS
Authors: Djafar Muliana , Mappiasse Muh Faisal 
Published: April 2019

Ekowisata merupakan suatu bentuk perjalanan wisata ke areal alami yang dilakukan dengan tujuan mengkonservasi lingkungan dan melestarikan kehidupan serta kesejahteraan penduduk setempat. Penelitian ini bertujuan: (1) mengidentifikasi potensi wisata yang ada pada Dusun Rammang-Rammang(2) menyusun strategi pengembangan ekowisata karst di Dusun Rammang-Rammang.Pendekatan penelitian ini kualitatif dengan teknik analisis data yang digunakan deskriptif kualitatif dan SWOT. Pengumpulan data melalui observasi lapangan,wawancara dan studi literatur.Hasil penelitian menunjukkan bahwa keragaman obyek wisata yang terdapat pada Dusun Rammang-Rammang sangat beragam, dimana dapat diketahui dengan teridentifikasinya potensi-potensi wisata yang terdapat pada kawasan tersebut, baik secara fisik, biologi maupun sosial budaya. Faktor pendukung yang terdiri dari kekuatan dan peluang, yaitu: merupakan tujuan wisata yang jarang ditemui karena keindahan karst yang eksotis, memiliki obyek wisata yang beragam,meningkatkan potensi sosial yang ada serta sumberdaya alam dapat terjaga dengan baik. Sedangkan faktor penghambat terdiri dari kelemahan dan ancaman, yaitu; obyek dan daya tarik wisata belum tertata dengan baik, pengelolaan obyek wisata yang kurang professional, kurangnya fasilitas pendukung, dan terbatasnya sumber dana bantuan dari pemerintah. Hasil perhitungan matrik IFAS dan EFAS menghasilkan nilai sumbu X sebesar 1.2 dan sumbu Y sebesar 0.8. Hal ini menunjukkan posisi strategis berada pada kuadran I, dengan rumusan strategi S-O, yaitu; mempertahankan keindahan serta keunikan sumberdaya alam agar tetap terjaga,melibatkan masyarakat luar dalam pengelolaan ekowisata, pembentukan lembaga potensi ekowisata dan menambah keragaman atraksi budayayang dikemas dalam satu paket wisata.
KOMPOSISI DAN CADANGAN KARBON EKOSISTEM MANGROVE TELUK BONE, KOTA PALOPO
Authors: Karim Hadijah Azis , Ahmad Afandi , Rosdayanti Andi 
Published: April 2019

Carbon storage at mangrove ecosystem is one of the largest compared between any vegetated ecosystem. Palopo City is one of the cities bordering teh Gulf of Bone and still have secondary mangrove ecosystem. This ecosystem become a good vegetated area which can provide environmental services in the form of CO2 uptake around Palopo City. This study aimed to analyze carbon storage at mangrove ecosystem at Palopo City. Furthermore, the value of carbon storage converted to CO2-eq value which described uptake at mangrove ecosystem. Method of this research is non destructive sampling and used existing allometric equations. Data collection carried out by measuring tree diameter in sampling plot 25 × 25 m with space between plot is 100 m. Result of this study showed that average of above ground carbon is 82.34±16.92 ton/ha equal to 301.90±62.03 ton/ha CO2-eq. The sequestration of CO2 based on each mangrove species at study area is Avicenia marina 55.26 ton/ha, Rhizophora apiculata 497.13 ton/ha, Rhizophora mucronata 2259.49 ton/ha, Rhizophora spp. 1975.62 ton/ha, Sonneratia alba 4268.43 ton/ha, Xylocarpus granatum 1.19 ton/ha.
Pengaruh Posisi Bukaan terhadap Penghawaan Alami pada Rumah Balai Padang
Authors: Yanti Rahma 
Published: April 2019

Penelitian ini bertujuan untuk mengetahui efek dari posisi dari bukaan yang ada di rumah Balai Padang. Metode yang digunakan adalah eksperimental dengan menggunakan bantuan software CFD (computational Fluid Dimension) berdasarkan persamaan Navier-Stoke, menggunakan K-Epsilon RNG. Eksperimen dilakukan dengan validasi hasil pengukuran lapangan This study aims to investigate the effect of position openings in Balai Padang house. The numerical methodology is based on solution of the Navier-Stokes equations, using K-epsilon RNG. Numerical results are validated with available field measurement data.
Meningkatkan Nilai Investasi Syariah Pada Reksadana Dengan Pengukuran Treynor-Mazuy Model Versus Henriksson-Merton Model
Authors: Rahayu Rika 
Published: April 2019

Penelitian ini bertujuan untuk menganalisis kemampuan market timing dan stock selection ability manajer investasi setiap reksadana saham syariah selama satu tahun. Penelitian ini merupakan penelitian yang bersifat kuantitatif dengan dua hipotesis diantaranya; Terjadi konsistensi market timing ability yang baik dari para manajer investasi dan Terjadi konsistensi stock selection ability yang baik dari para manajer investasi. Variabel yang digunakan pada penelitian ini diantaranya variabel dependen yaitu kinerja reksadana dan variable independen diantaranya stock selection skill dan market timing ability. Dalam penelitian ini menggunakan model pengukuran reksadana dengan model Treynor- Marzuy dan Henriksson-Merton. Penelitian ini membutuhkan data Nilai Aktiva Bersih (NAB), Risk Free Rate dan Indeks Harga Saham Gabungan. Hasil pengukuran menggunakan metode Treynor dan Mazuy menyatakan hanya satu yang memiliki kemampuan market timing tetapi tidak memiliki kemampuan selectivity yaitu reksadana Sucorinvest Sharia Equity Fund, sedangkan pengukuran dengan menggunakan metode Henriksson-Merton menyatakan hanya satu yang memiliki kemampuan market timing dan selectivity yaitu reksadana saham syariah Sucorinvest Sharia Equity Fund. This study aims to analyze the ability of market timing and stock selection ability the investment managers any mutual fund syariah shares for a year. This research was quantitative study with two hyphotesis were the consistency of market timing ability by investment managers and occurring the consistency of stock selection ability by the investment managers. Variables in this research was likes dependend variable were mutual fund performance and independend variable were stock selection skill and market timing ability. This research used measurement model for mutual fund with Treynor-Mazuy model and Henriksson-Merton model. This research needs net asset value (NAV), risk free rate and Indonesia Composite Index. The result of measurement with Treynor and Mazuy method describe had only one market timing ability but han’t selectivity was Sucorinvest Sharia Equity fund, while measurement with Henriksson-Merton method describe had only one market timing ability and selectivity was Syariah Sucorinvest Fund.
Pengaruh Variabel Internal Perbankan Terhadap Kinerja Bank Konvensional di Indonesia
Authors: Akbar Ali 
Published: April 2019

This research is to know the influence of internal variables of banking (amount of credit and operational expense than operating income (BOPO)) on the performance of conventional banks. The population in this research is the whole of conventional commercial banks in Indonesia year of 2010-2017. The sampel is the conventional commercial banks by as much as 14 banks, with time series data. The method used is the analysis of partial least square (PLS). The results showed that internal variables of banking (amount of credit, BOPO) negative and no significant effect on performance of conventional banks (CAR, NPL, ROA, LDR) and amount of credit credit is an indicator of a dominant influence variation/change from a conventional banks performance factors (CAR, NPL, ROA and LDR).
Impacto do uso do cicloergômetro na função respiratória, cardiovascular, capacidade aeróbica, funcional e qualidade de vida de pacientes com doença renal crônica em hemodiálise
Authors: Fernandes Antonio de Olival , Sens Yvoty Alves dos Santos , Fonseca Júnior Paulo Roberto , Moura Renata Calhes Franco de , Alves Vera Lúcia dos Santos 
Published: April 2019

Investigar por meio de uma revisão sistemática o impacto do uso de cicloergômetro na função respiratória, cardiovascular, capacidade aeróbica, funcional e qualidade de vida em pacientes com doença renal crônica durante a hemodiálise. Métodos: A pesquisa buscou referências de janeiro de 2010 a dezembro de 2018. Foram incluí­das as bases Pubmed, Scielo, PEDro, Lilacs e Cochrane Library e foram usadas palavras-chave pré-selecionadas. Os artigos encontrados foram avaliados pela escala PEDro. A busca e análise foram realizadas por dois autores de forma independente. Resultados: Um total de 81 artigos foi identificado, no entanto apenas quatro atendiam aos critérios de inclusão e exclusão. Devido ao pequeno número de artigos incluí­dos e í sua heterogeneidade, seus resultados não puderam ser submetidos í metanálise e foram apresentados de forma descritiva. Conclusão: O exercí­cio aeróbico com uso de cicloergômetro realizado durante as sessões de hemodiálise promove melhora da capacidade aeróbia e condicionamento fí­sico e por consequência na qualidade de vida.Palavras-chave: doença renal crônica, diálise renal, terapia por exercí­cio, técnicas de exercí­cio e de movimento.
A influência da Fisioterapia na redução da intensidade da dor e no efeito global percebido de pacientes com dores musculoesqueléticas
Authors: Chaves Aline Oliveira , Almeida Renato Santos , Corrêa Leticia Amaral , Dos Reis Felipe José Jandre , Meziat-Filho Ney Armando Mello , Nogueira Leandro Alberto Calazans 
Published: April 2019

A melhora clí­nica do paciente com dores musculoesqueléticas (DME) deve ser monitorada em conjunto com a percepção do paciente sobre o efeito do tratamento, apesar da falta de informação sobre esse tema. Objetivo: Analisar a influência do tratamento fisioterápico na redução da intensidade da dor e no efeito global percebido de pacientes com DME. Métodos: Foi realizado um estudo observacional analí­tico retrospectivo em 61 pacientes com DME que responderam uma questão relacionada í intensidade de dor e outra questão sobre o efeito global percebido do tratamento fisioterápico. A intensidade de dor medida após 10 meses de acompanhamento foi comparada aos valores iniciais. Resultados: Os participantes eram predominantemente mulheres (83,3%) adultas (média de idade de 59,6 anos). A média de intensidade da dor na avaliação inicial foi de 6,4 (± 2,7), com média de tempo de dor de 20,3 meses. A média de intensidade de dor após o contato telefônico foi de 4,37 (± 3,9). A análise do efeito global percebido evidenciou melhora na maioria dos participantes (16,7% completamente recuperados; 39,7% melhoraram muito, 26,7% melhoraram pouco). Conclusão: Pacientes com DME apresentaram redução da intensidade da dor e melhora no efeito global percebido após um programa de Fisioterapia.Palavras-chave: fisioterapia, dor crônica, dor musculoesquelética, intensidade de dor, efeito global percebido.
Déficits vestibulares e vertigem posicional paroxí­stica benigna em adultos jovens assintomáticos: um estudo transversal
Authors: Sales Nádia de Sousa , Sérvulo Maria de Fátima Passos , Martins e Silva Diandra , Rocha Kaline , Teixeira Silmar , Orsini Marco , Velasques Bruna , Ribeiro Pedro , Nader Sergio , Moreno Adalgiza Mafra , Silva Janaí­na de Moraes , Do Vale Bastos Victor Hugo 
Published: April 2019

Introdução: O equilí­brio corporal pode ser afetado por déficits visuais, proprioceptivos e/ou vestibulares centrais ou periféricas. Dentre as afecções vestibulares periféricos, a Vertigem Postural Paroxí­stica Benigna apresenta grande interesse em pesquisas que buscam responder suas apresentações clí­nicas em adultos e sua associação com a integralidade dos demais sistemas corporais. Objetivo: Analisar as respostas de adultos jovens assintomáticos submetidos í semiologia do sistema vestibular. Metodologia: Estudo quantitativo, transversal analí­tico e descritivo, onde foram utilizados os testes de equilí­brio estático, dinâmico e a manobra de Dix-Hallpike, com amostra de 30 voluntários assintomáticos recrutados em uma instituição de ensino superior do municí­pio de Parnaí­ba/PI. Resultados: O teste de apoio unipodal (1,87 ± 0,346) foi negativo (p < 0,001) e no teste de Fukuda (1,20 ± 0,407) grande parte tiveram resultados positivos (p < 0,001). Os testes de Romberg (2,00 ± 0,000), Romberg-Barré (1,50 ± 0,509) e Babinski-Weil (1,37 ± 0,490) não foram significantes (p = 0,001). Para a Manobra de Dix-Hallpike observamos que os movimentos de sedestação para decúbito dorsal esquerdo e de decúbito dorsal para sedestação direito e esquerdo foram significativos (p < 0,001). Conclusão: Os adultos jovens assintomáticos podem apresentar resultados positivos em teste de equilí­brio e sintomas na manobra de Dix-Hallpike, confirmando a Vertigem Postural Paroxí­stica Benigna.Palavras-chave: doenças vestibulares, equilí­brio postural, testes de função vestibular.