bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strong Ion‐Dipole Interactions for Stable Zinc‐Ion Batteries with Wide Temperature Range
Authors: Huang Hao , Du Qinling , Chen Zixuan , Deng Hongzhong , Yan Changyuan , Deng Xianyu 
Published: November 2024

AbstractAqueous zinc‐ion batteries are widely recognized as promising alternatives to lithium batteries due to their excellent safety, environmental compatibility, and cost‐effectiveness. Nonetheless, the formation of dendrites, corrosion, and undesirable side reactions on the zinc surface pose significant challenges to the cycling stability of zinc‐ion batteries. In this study, polar propylene carbonate (PC) is paired with tetrafluoroborate anions to establish a strong ion‐dipole interaction. Strong ion‐dipole interaction can not only alter the solvation structure of zinc ions but also facilitate the formation of a dynamic double electric layer on the surface of the zinc electrode, suppressing the formation of ZnF2 interface and carbonate, thereby facilitating uniform zinc ion deposition, and consequently improving battery cycling stability over a broad temperature range. Concretely, the formulated electrolyte enhances the cycling stability of the battery over a wide temperature range of −30 to 40 °C, accompanied by a capacity retention of ≈100% even after 10 000 cycles at −30 °C. The symmetrical battery utilizing this electrolyte exhibits stable cycling performance for over 1200 h at 25 °C and 1900 h at −30 °C, respectively. The findings provide a promising direction for the development of long‐cycle batteries capable of operating over a wide temperature range.
Recent Advances in Nanomaterial‐Mediated Cell Death for Cancer Therapy
Authors: Luo Min , Wang Yuan‐min , Zhao Fu‐kun , Luo Yong 
Published: November 2024

AbstractNanomedicine has shown great anticancer potential by disrupting redox homeostasis and increasing the levels of oxidative stress, but the therapeutic effect is limited by factors including the intrinsic self‐protection mechanism of tumors. Cancer cell death can be induced by the exploration of different cell death mechanisms, such as apoptosis, pyroptosis, necroptosis, cuproptosis, and ferroptosis. The merging of nanotechnology with biomedicine has provided tremendous opportunities to construct cell death‐based nanomedicine for innovative cancer therapy. Nanocarriers are not only used for the targeted delivery of cell death inducers, but also as therapeutic components to induce cell death to achieve efficient tumor treatment. This review focuses on seven cell death modalities mediated by nanomaterials, such as apoptosis, pyroptosis, necroptosis, ferroptosis, cuprotosis, immunogenic cell death, and autophagy. The mechanisms of these seven cell death modalities are described in detail, as well as the preparation of nanomaterials that induce them and the mechanisms, they used to exert their effects. Finally, this work describes the potential future development based on the current knowledge related to cell death induced by nanomaterials.
Ultrafast Na‐Ion Storage in Amorphization Engineered Hollow Vanadium Oxide/MXene Nanohybrids for High‐Performance Sodium‐Ion Hybrid Capacitors
Authors: Yuan Jun , Pan Duo , Chen Junxiang , Liu Yangjie , Yu Jiaqi , Hu Xiang , Zhan Hongbing , Wen Zhenhai 
Published: November 2024

AbstractSodium ion hybrid capacitors (SIHCs) address the high power and energy requirements in energy storage devices but face significant challenges arising from the slow kinetics and cycling instability of the anode side. Introducing atomic disorder and employing structural engineering in anode materials proves to be effective strategies for achieving rapid charge storage. Here, it is demonstrated that N‐doped MXene encapsulated amorphous vanadium oxide hollow spheres (VOx@N‐MXene HSs) offer multidirectional open pathways and sufficient vacancies, enabling reversible and fast Na+ insertion/extraction. Machine learning potentials, coupled with molecular simulation techniques, confirm the presence of more abundant pores within the amorphous vanadium oxide (VOx) structure. The simulation of the charging/discharging process elucidates the authentic reaction path and structural evolutions of the VOx@N‐MXene HSs, providing sufficient insight into the atomic‐scale mechanisms associated with these structural superiorities. The full SIHCs devices demonstrate a high energy density of 198.3 Wh kg−1, along with a long‐term cycling lifespan of 8000 cycles. This study offers valuable strategies into the intricate design and exploration of amorphous electrodes, contributing to the advancement of next‐generation electrochemical energy devices.
A Supramolecular Wire Able to Self‐Assemble on Gold Surface: Controlling the Film Length to Optimize the Device Lifetime and Electron Transfer Efficiency
Authors: Kubitzky Sascha , Lettieri Raffaella , Passaretti Elena , Venanzi Mariano , De Zotti Marta , Mazzuca Claudia , Placidi Ernesto , Gatto Emanuela 
Published: November 2024

AbstractA chemical “lego nanoset” has been used to realize different structures on gold surfaces. Three building blocks have been designed, in order to chemically link the surface and self‐assemble in an ordered manner. Self‐assembled films are arranged on a gold surface into 3D suprastructures via consecutive deposition of different mono‐layers, taken together by thymine‐adenine hydrogen bonds. Three films, composed of one, two, and three helical peptide layers, both containing a zinc‐tetraphenylporphyrin dye as an external sheet, are built and characterized by spectro‐electrochemical and spectroscopic techniques. All films are found to generate current under illumination, and their photoresponse and stability are studied as a function of the number of peptide layers. The efficiency of the photoconversion process has been correlated to the molecular organization of the porphyrin dyes in the film and to the templating role of the bridge between the porphyrin and the gold surface.
Highly Efficient and Integrated Nonlinear Airy Beams Generation
Authors: Yang Qian , Ye Xiaona , Liu Haigang , Chen Xianfeng 
Published: November 2024

AbstractOwing to its peculiar non‐diffraction, self‐acceleration, and self‐healing properties, the Airy beam has attracted a great deal of attention in various fields such as micro‐manipulation, plasma generation, and optical microscopy. To date, it is still a challenge to generate nonlinear Airy beams with microstructure efficiently, thus limiting applications of such Airy beams. Here, a novel and efficient method for generating Airy beams is experimentally demonstrated by microstructure on a nonlinear crystal surface, which is fabricated by a focused ion beam (FIB) technique. The second‐harmonic (SH) Airy beams are generated in the far field and characterize their intensity distributions, which agree well with theoretical results. Then, the self‐accelerating and self‐healing properties of the generated SH Airy beams are demonstrated. Besides, the normalized efficiency of SH Airy beams is measured at (1.44 × 10−5%W−1), and compare the efficiency of different methods of generating nonlinear Airy beams, which shows the advantages of this method. The proposed method of generating nonlinear Airy beams shows great potential for integrated optics, optical micro‐machining, and advanced imaging.
Visible‐Light Enabled Synthesis of 1‐Aryl‐3‐Sulfonylmethyl‐1,2,4‐Triazoles by Arylazo Sulfones
Authors: Nicchio Luca , Di Terlizzi Lorenzo , Fagnoni Maurizio , Neuville Luc , Protti Stefano , Masson Geraldine 
Published: November 2024

AbstractWe present a novel and highly efficient method for synthesizing polyfunctionalized 1,2,4‐triazoles. This approach leverages visible light and arylazo sulfones in combination with N‐vinyl amides, in the environmentally friendly solvent ethyl acetate. Remarkably, the reaction proceeds without the need for (photo)catalysts, ensuring near‐perfect atom economy and producing only water as a by‐product. This method exhibits excellent functional group tolerance and can be scaled for both batch and continuous‐flow processes.
Synthesis of 3‐Chloroindoles via Palladium‐Catalyzed Chlorocyclization of Unmasked 2‐Alkynylanilines
Authors: Zheng Yongpeng , Li Jianxiao , Wu Wanqing , Qi Chaorong , Jiang Huanfeng 
Published: November 2024

AbstractDescribed herein is the discovery of a palladium‐catalyzed chlorocylization strategy for the synthesis of 3‐chloroindoles tolerated with a wide range of functional groups in moderate to excellent yields. In this transformation, the solvent effect is so important that only THF presents the positive effect. Furthermore, the present method provides an essay access to the N‐unprotected 3‐chloroindoles. A mechanism study showed that 2‐alkynlanilines were catalyzed by palladium to from corresponding indoles, followed by copper‐mediated oxidation chlorination to deliver the 3‐chloroindoles products.
Luminescent Multifunctional Nanomaterials: Capacitive Removal and Enhanced Detection Efficiency of Heavy Metals Ions for Advanced Water and Wastewater Treatment Application
Authors: Chenab Karim Khanmohammadi , Zamani‐Meymian Mohammad‐Reza , Qasemi Elham 
Published: November 2024

AbstractIn recent years, heavy metal ions pollution in the industrialized environment of the societies threaten human health that flaunt ill‐sorted blueprints in freshwater resources obviously. The paradigm of designing luminescent multifunctional nanomaterials finds directions to the strategies of synthesizing cost‐effective, green, and versatile nanomaterials not only for detection, but also removal process of heavy metal ions in large scale applications. Among them, discovering the advances of luminescent multifunctional nanomaterials provides broad types of biomaterials, polymers and porous nanoparticles that grabs focal of investigations over the past several years due to their unique advantages such as enhanced detection efficiency with lowest limit of detection (LOD), minimum ions interference in versatile removal process, fast responsivity and selectivity as outstanding as unique physicochemical properties. This review paper tries to highlight the paradigm of principles for design, development, and utilization of luminescence nanomaterials for considering fundamental detection and removal mechanisms of heavy metal ions. In particular, these nanomaterials increase the remediation quality that are tackled in detail by focusing on opportunities and challenges in the field. Finally, design methods of these nanomaterials and concentrating on empowered detection and removal efficiency for heavy metals ions highlights novel prospective and strategies for largescale applications.
Nanotechnology‐Based Systems for Enhancing the Efficacy of Sonodynamic Therapy in Cancer Treatment
Authors: Wang Yidong , Nomikou Nikolitsa 
Published: November 2024

AbstractSonodynamic therapy (SDT) is a minimally invasive cancer therapeutic modality that utilizes low‐intensity ultrasound to activate sensitizers for the production of cytotoxic reactive oxygen species (ROS) and the site‐specific ablation of tumors. Compared to conventional cancer treatments, SDT has no adverse side effects, has been shown to radically reduce tumor volume, and has the potential to raise antitumor immune response. Ever‐increasing studies have demonstrated that nanotechnology can significantly enhance the efficacy of SDT against certain cancers and improve its therapeutic effects. Nanosystems are developed that can improve the intratumoral delivery and cellular uptake of sensitizers, can reduce intrinsic cancer defenses against ROS, can act synergistically for the production of ROS and can tackle cancer immune tolerance. In this review, the various strategies to enhance SDT performance with the assistance of nanotechnology, and the outstanding research outcomes, are discussed.
The Effect of Hydrostatic Pressure on Structure, Crystal‐Field Strength, and Emission Properties of Neat and Ni2+‐Activated KMgF3
Authors: Umar Zafari , Khyzhun Oleg , Kurboniyon Mekhrdod S. , Yamamoto Tomoyuki , Brik Mikhail G. , Novita Mega , Barzowska Justyna , Piasecki Michal 
Published: November 2024

AbstractTo understand excellent emission and sensitivity for hydrostatic pressure luminescent ions host material, the first principles calculations carried out within density functional theory (DFT) framework are performed to clarify the electronic structure of neat and doped with Ni2+ ions KMgF3 single crystals. The results of band structure calculations show that F2p states are the principal contributors to the KMgF3 valence band, mainly in its upper and central parts, while in the energy band gap of the KMgF3:Ni2+ phosphor, new electronic states associated with the Ni2+ 3d‐orbitals are formed. Furthermore, the zero phonon line (ZPL) spin‐forbidden transition emission energies, (3A2⇄1E) ZPL, (3A2⇄3T2) ZPL, strength of the octahedral crystal field, 10Dq (3A2→3T2)ZPL, are calculated for the KMgF3:Ni2+ phosphor. Any changes of the Em(3A2⇄1E)ZPL transition energy of the KMgF3:Ni2+ phosphor with pressure increasing from 0 to 20 GPa are not detected, while the crystal‐field strength increases linearly with increasing pressure. Present results bring a foresight tool for predicting physicochemical properties of undoped and doped wide‐gap fluorides; KMgF3:Ni2+, without any toxic/harmful or expensive rare‐earth can be effectively used as an optical manometer in 0–20 GPa, which covers the almost whole pressure range available at present in Diamond anvil cell experiments.
TBL2 Promotes Tumorigenesis via PRMT5/WDR77‐Mediated AKT Activation in Breast Cancer
Authors: Lu Xiuqing , Zhang Chao , Zhu Lewei , Wang Sifen , Zeng Lijun , Zhong Wenjing , Wu Xuxia , Yuan Qi , Tang Hailin , Cui Shien , Tan Yeru , Li Yuehua , Wei Weidong 
Published: November 2024

AbstractBreast cancer (BC) is a common malignancy that affects women worldwide. Although transducing beta‐like 2 (TBL2), a member of the WD40 repeat protein family, has been implicated in various intracellular signaling pathways, its precise function in BC remains unclear. The expression of TBL2 is analyzed using real‐time PCR, western blotting, and immunohistochemistry in BC patient specimens. Kaplan–Meier survival analysis is employed to assess its prognostic significance. Proteomic analysis, immunoprecipitation tests, and protein immunoblotting are employed to examine the impact of TBL2 on AKT phosphorylation activation. The findings reveal selective overexpression of TBL2 in BC, correlating significantly with various clinicopathological characteristics and poor survival outcomes in patients with BC. Through in vivo and in vitro experiments, it is observed that TBL2 suppression inhibits BC cell proliferation, while TBL2 overexpression has the opposite effect. Mechanistically, TBL2 is identified as a scaffolding protein that promotes PRMT5 and WDR77 interaction. This interaction enhances the methyltransferase activity of PRMT5, leading to increased AKT phosphorylation activation and promotion of breast cancer cell proliferation. In conclusion, this study uncovers a novel function of TBL2 in the activation of AKT by PRMT5 and suggests TBL2 as a potential therapeutic target for BC treatment.
Targeting SLITRK4 Restrains Proliferation and Liver Metastasis in Colorectal Cancer via Regulating PI3K/AKT/NFκB Pathway and Tumor‐Associated Macrophage
Authors: Sun Xiaojiao , Zhang Junling , Dong Bingqi , Xiong Qingqing , Wang Xin , Gu Yanlun , Wang Zhiqi , Liu Huiyu , Zhang Jixin , He Xu , Liu Hongjin , Zhong Yi , Yi Chuxiao , Chi Xiaowei , Liu Zhenming , Pang Xiaocong , Cui Yimin 
Published: November 2024

AbstractLiver metastasis is the major cause of death in colorectal cancer (CRC) due to the lack of effective treatment. To explore novel drivers of CRC liver metastasis, the transcriptomes of primary paracancerous, colorectal tumors and metastases from human patients are profiled. It is found that SLIT‐ and NTRK‐like family member 4 (SLITRK4) is the top upregulated gene in liver metastases and is associated with worse overall survival of CRC patients. Multiple in vitro and in vivo models suggested SLITRK4 promoted CRC tumorigenesis, invasion, migration, and angiogenesis, and inhibition of it restrained CRC tumor growth and liver metastasis with a more profound effect on the tumor microenvironment (TME). Mechanistically, SLITRK4 overexpression significantly activated the PI3K/AKT/NFκB pathway, regulated extracellular matrix organization, and multiple cytokines expression. Furthermore, the results from coculture models and single‐cell RNA sequencing analyses suggested SLITRK4 promoted tumor‐associated macrophages (TAMs) infiltration and polarization. In addition, macrophage depletion significantly inhibited SLITRK4‐induced liver metastasis in CRC. Finally, pharmacological inhibition of SLITRK4 by using lipid‐polymer hybrid nanoparticles (NPs) for systemic siRNA delivery can effectively inhibit CRC liver metastasis. Taken together, these results pinpoint that SLITRK4 regulates CRC tumorigenesis and liver metastasis, and siRNA delivering NPs agents validate the therapeutic potential of targeting SLITRK4 in CRC.
The Spatial‐Temporal Alternative Splicing Profile Reveals the Functional Diversity of FXR1 Isoforms in Myogenesis
Authors: Wang Wei , Fan Xinhao , Liu Weiwei , Huang Yuxin , Zhao Shuhong , Yang Yalan , Tang Zhonglin 
Published: November 2024

AbstractAlternative splicing (AS) is a fundamental mechanism contributing to proteome diversity, yet its comprehensive landscape and regulatory dynamics during skeletal muscle development remain largely unexplored. Here, the temporal AS profiles are investigated during myogenesis in five vertebrates, conducting comprehensive profiling across 27 developmental stages in skeletal muscle and encompassing ten tissues in adult pigs. The analysis reveals a pervasive and evolutionarily conserved pattern of alternative exon usage throughout myogenic differentiation, with hundreds of skipped exons (SEs) showing developmental regulation, particularly within skeletal muscle. Notably, this study identifies a muscle‐specific SE (exon 15) within the Fxr1 gene, whose AS generates two dynamically expressed isoforms with distinct functions: the isoform without exon 15 (Fxr1E15−) regulates myoblasts proliferation, while the isoform incorporating exon 15 (Fxr1E15+) promotes myogenic differentiation and fusion. Transcriptome analysis suggests that specifically knocking‐down Fxr1E15+ isoform in myoblasts modulates differentiation by influencing gene expression and splicing of specific targets. The increased inclusion of exon 15 during differentiation is mediated by the binding of Rbm24 to the intron. Furthermore, in vivo experiments indicate that the Fxr1E15+ isoform facilitates muscle regeneration. Collectively, these findings provide a comprehensive resource for AS studies in skeletal muscle development, underscoring the diverse functions and regulatory mechanisms governing distinct Fxr1 isoforms in myogenesis.
In Situ Growth of Mushroom‐Shaped Adhesive Structures on Flat/Curved Surfaces via Electrical Modulation
Authors: Tian Hongmiao , Li Yingze , Wang Duorui , Chen Qi , Jiang Yuanze , Liu Tianci , Li Xiangming , Wang Chunhui , Chen Xiaoliang , Shao Jinyou 
Published: November 2024

AbstractGecko‐inspired adhesives have an extraordinary impact on robotic manipulation and locomotion. However, achieving excellent adhesive performance on curved surfaces, especially undevelopable surfaces, is still challenging. This can be attributed to a considerable difference between the fabrication method and practical necessity, i.e., the adhesive structures are generally fabricated on a flat substrate whereas the manipulating surface is curved, resulting in a low adhesive strength. Here, an in‐situ growth strategy is proposed to fabricate mushroom‐shaped structures at micro/nano‐scale via electrical modulation on flat or curved surfaces. Since the adhesive structures are directly grown on target surfaces without a transfer procedure, they exhibit a large contact area and stress uniformity at the interface, corresponding to an excellent adhesive force. A comparison between grown structures using the proposed method and those fabricated using traditional approaches suggests that the adhesive forces are identical for flat testing surfaces, while the difference can be up to 4 times for developable surfaces and even 25 times for undevelopable surfaces. The proposed adhesion strategy extends the application prospects of gecko‐inspired adhesives from flat surfaces to curved ones, composed of developable and undevelopable surfaces, opening a new avenue to develop gecko‐inspired adhesive‐based devices and systems.
Isolation and Comprehensive Analysis of Cochlear Tissue‐Derived Small Extracellular Vesicles
Authors: Jiang Pei , Ma Xiangyu , Wang Xinlin , Huang Jingyuan , Wang Yintao , Ai Jingru , Xiao Hairong , Dai Mingchen , Lin Yanqin , Shao Buwei , Tang Xujun , Tong Wei , Ye Zixuan , Chai Renjie , Zhang Shasha 
Published: November 2024

AbstractSmall extracellular vesicles (sEVs) act as a critical mediator in intercellular communication. Compared to sEVs derived from in vitro sources, tissue‐derived sEVs can reflect the in vivo signals released from specific tissues more accurately. Currently, studies on the role of sEVs in the cochlea have relied on studying sEVs from in vitro sources. This study evaluates three cochlear tissue digestion and cochlear tissue‐derived sEV (CDsEV) isolation methods, and first proposes that the optimal approach for isolating CDsEVs using collagenase D and DNase І combined with sucrose density gradient centrifugation. Furthermore, it comprehensively investigates CDsEV contents and cell origins. Small RNA sequencing and proteomics are performed to analyze the miRNAs and proteins of CDsEVs. The miRNAs and proteins of CDsEVs are crucial for maintaining normal auditory function. Among them, FGFR1 in CDsEVs may mediate the survival of cochlear hair cells via sEVs. Finally, the joint analysis of single CDsEV sequencing and single‐cell RNA sequencing data is utilized to trace cellular origins of CDsEVs. The results show that different types of cochlear cells secrete different amounts of CDsEVs, with Kölliker's organ cells and supporting cells secrete the most. The findings are expected to enhance the understanding of CDsEVs in the cochlea.
Triphenylamine‐Functionalized Metal Nanoclusters for Efficient and Stable Perovskite Solar Cells
Authors: Wang Lin , Du Jieru , Wu Jiahao , Nan Zi‐Ang , Li Simin , Tang Xiongkai , Xie Zhenlang , Xu Qinghua , Gong Xuekun , He Jinlu , Chen Ruihao , Zheng Nanfeng , Shen Hui 
Published: November 2024

AbstractReported herein is a ligand engineering strategy to develop photoelectric active metal nanoclusters (NCs) with atomic precision. Triphenylamine (TPA), a typical organic molecule in the photoelectric field, is introduced for the first time to prepare atomically precise metal NCs that prove effective in the fabrication of perovskite solar cells (PSCs). The scalable synthetic prototype, unique electronic strucuture, and atomically precise structure of the cluster ([(AgCu)37(PPh3)8(TPA‐C≡C)24]5+) are illustrated in this work. When being employed as a buffer layer in the perovskite/HTL interface of PSCs, significantly enhanced performance is observed. The resultant n‐i‐p devices achieved a substantial power conversion efficiency as high as 25.1% and long‐term stability. The findings offer valuable insights into preparing functionalized metal NCs that play multiple roles in improving the performance of the device: while the inorganic metal core enhances conductivity, the organic TPA shell promotes the “carrier transfer” between the perovskite and HTL layer and prevents the perovskite from corrosion.