bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Bahan Ajar Dengan Menggunakan Pendekatan Saintifik Untuk Meningkatkan Kreatifitas Siswa Di Kelas X Sekolah Menengah Atas
Authors: Agustina Fitri , Azizah Jalilah 
Published: October 2019

his study aims to produce a teaching material based on the scientific approach that is valid, practical, and effective and can increase creativity in biology learning in high school class X. The method used in this development is the 4-D Model (Four D Model) development model, which consists of four stages are: define, design, develop, and spread (disseminate). Development research is a research method for developing products and improving products. The defining stage is carried out by the determination of learning conditions by analyzing competency standards and boundaries of the subject matter that will be taught by the teacher based on the 2013 curriculum content standards. The planning stage for the preparation of instruments needed in this study and the design of prototype teaching materials. Development stage 1) expert appraisal followed by revision, and 2) development trials limited to students (developmental testing). Stage of dissemination (disseminate) by publishing teaching material that has been developed in the form of a journal. The ability of students has increased, this can be seen from the percentage of classical completeness of students in the first trial of 36%, and the percentage of classical completeness of students in the second trial was 83%. In other words an increase in the biological representation of students in the ecosystem material from the first trial to the second trial increased. Keywords: Development, Teaching Materials, Creativity
A standardized suppresses breast cancer cell proliferation by regulating the expression of EphA2 antisense RNA-mRNA axis independently of micro RNA
Authors: Sakamoto Ryou , Kumagai Kazuhiro , Odaka Tokifumi , Okuyama Tetsuya , Nishizawa Mikio , Kimura Tominori 
Published: October 2019

AbstractBackground: A standardized extract of cultured Lentinula edodes mycelia (ECLM), an extract from cultured Lentinula edodes, has been reported to suppress breast cancer stem cell proliferation by regulating microRNA (miR) expression. Natural antisense RNAs (ASs), a type of protein non-coding RNA, can regulate the expression of protein-coding genes by acting as a competing endogenous RNA (ceRNA) that adsorbs miRNAs, resulting in the prevention of mRNA degradation, and can also form a transient RNA duplex with mRNA. EphA2, a receptor tyrosine kinase, is typically expressed at low levels in normal epithelial cells, whereas its overexpression has been widely observed in numerous solid tumors and is associated with cell transformation, primary tumor initiation, and tumor progression. Objective: This study aimed to investigate the effect of ECLM on the expression of both EphA2 mRNA and endogenous AS to this mRNA, which could negatively affect human breast carcinoma cell proliferation. Methods: We used MCF7 and MDA-MB-231 human breast carcinoma cells, which were sub-cultured three times in the presence of optimized concentrations of ECLM. The effect of ECLM on the expression of EphA2 AS and mRNA was analyzed by RT-qPCR. miRNAs targeting both EphA2 AS and EphA2 mRNA and their RNA miR response elements (MREs) were predicted and analyzed by RT-qPCR and luciferase reporter assays. Results: ECLM suppressed the proliferation of MCF7 and MDA-MB-231 cells in a dose-dependent manner. In cells for which proliferation was negatively affected by ECLM, EphA2 AS and mRNA expression was also significantly inhibited by ECLM. Although neutralization of miR-335 led to the de-repression of both EphA2 AS and mRNA, results did not fully support the possibility that EphA2 AS might function as a ceRNA to regulate EphA2 mRNA levels. Conclusion: ECLM suppressed the proliferation of breast carcinoma cells in a specific dose-dependent manner. This suppressive effect was associated with a concordant reduction in both EphA2 AS and mRNA expression. These effects were not thought to occur via the reported ceRNA effect. These results thus suggest that ECLM could regulate EphA2 AS and mRNA expression by forming a transient RNA duplex formation, thereby stabilizing EphA2 mRNA. Keywords: ECLM, regulatory RNA, antisense RNA, microRNA, EphA2
Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies?
Authors: Shuba Ya.M. 
Published: October 2019

Summary. The ORAI family of ion channel-forming proteins in mammals includes three members, ORAI1, ORAI2 and ORAI3, encoded by homologous genes. Of these proteins the ORAI1 one received major attention as plasma membrane constituent of store-operated calcium entry (SOCE) in non-excitable cells. The functional significance of two other proteins, ORAI2 and ORAI3, is much less defined, although both of them participate to various extends in cell-specific modulation of SOCE as well as in supporting some of the store-independent calcium entry mechanisms. Calcium signaling becomes remodeled in cancer to promote cancer hallmarks — enhanced proliferation, resistance to apoptosis, motility and metastasizing. Although such remodeling commonly involves rearrangements of the whole molecular Ca2+-handling toolkit of the cell (Ca2+ pumps and transporters, Ca2+-binding and storage proteins, Ca2+ entry and release channels, Ca2+-dependent effectors), Ca2+ entry through Orai-based channels is especially important, as its dysregulation may contribute to several cancer hallmarks. The latter depend on the type of Ca2+-permeable channel formed by ORAI-proteins, spatiotemporal characteristics of Ca2+ signal that this channel contributes to, and the type Ca2+-dependent effector(s) targeted by this signal, all of which may be cancer-specific. By participating in global Ca2+ entry, ORAI-based SOCE may also contribute to cytosolic Ca2+ overload of cancer cells thereby playing pro-apoptotic, antineoplastic roles which can potentially be exploited for cancer treatment. This mini review examines various aspects of ORAI proteins in malignant transformation.
PERSEPSI PEMAHAMAN PERANAN AUDITOR, ETIKA AUDITOR DAN INDEPENDENSI AUDITOR INTERNAL DALAM MEWUJUDKAN GOOD UNIVERSITY GOVERNANCE DENGAN GAYA KEPEMIMPINAN SEBAGAI VARIABEL MODERASI
Authors: S Fipiariny 
Published: October 2019

ABSTRACT The purpose of this study is to examine and analyze the influence of the role, ethics, and independence of internal auditors in implementing good university governance (GUG) with leadership style as a moderation variable. Multiple linear regression and moderation regression analysis models are used to test the hypothesis. The primary data are obtained through questionnaires that are distributed to the respondents, namely the dean and head of study program at the UniversitasBinaDarma and UniversitasMuhammadiyahPalembang. The results of this study indicate that the instruments in each variable proved to be valid and reliable. Based on the results of hypothesis testing, it can be seen that simultaneously the variable of role, ethics, and independence of internal auditors have positively and significantly effect in implementing good university governance (GUG). These results provide justification or endorsement of the theoretical truths used as the theoretical references of Stewardship Theory and Attitude and Behavioral Theory. Based on the partial test, role of auditor does not significantly affect the variable of GUG, but ethics and independence variable are found to be significant in influencing GUG. The leadership style is negative and insignificant in moderating the role of internal auditors and GUC and also the independence of internal auditor and GUC. The leadership style is found to be positive and insignificant in moderating the relationship of internal auditors’ ethics and GUC.
KARAKTERISASI LAJU ALIRAN MASSA PADA PIPA BAGIAN HEATER BERDASARKAN PERUBAHAN DAYA DI UNTAI (FASSIP-01) MOD.1
Authors: Fauzi Ahmad , Juarsa Mulya , Giarno Giarno , Heru Gregorius Bambang , Haryanto Dedy , Irianto Ignatius Djoko 
Published: October 2019

<p>Kecelakaan reaktor nuklir di Fukushima Daiichi Jepang pada 11 Maret 2011, menyebabkan dilakukannya penelitian ini di berbagai negara termasuk Indonesia yang sedang mengembangkan sistem keselamatan pasif dengan alat Untai FASSIP-01 Mod.1 di PTKRN-BATAN Serpong. Ada beberapa komponen pada Untai FASSIP-01 Mod.1 yaitu komponen pemanas yang dinamakan <em>Blanke</em><em>t </em><em>Ceramic Heater</em> (BCH-02), komponen pendingin dengan sistem <em>refrig</em><em>e</em><em>rant </em><em>cooling system</em> (RCS), dan tabung ekspansi. Sistem pasif menerapkan hukum alami untuk mengamati kondisi yang tidak stabil pada reaktor. Perlu dilakukannya eksperimen untuk mengetahui karakterisasi distribusi temperatur pada pemanas BCH-02 di Untai FASSIP-01 Mod.1 dengan memvariasikan daya dan tegangan 20 volt – 160 volt. Pengujian dilakukan selama 120 menit dan tegangan dinaikkan sebesar 20 volt selama 15 menit, eksperimen pada BCH-02 dilakukan dengan posisi vertikal dan horizontal. Hasil eksperimen pada BCH-02, semakin besar daya yang diberikan maka temperaturnya semakin tinggi. Temperatur yang berada di permukaan <em>ceramic-brick</em> lebih tinggi dibandingkan dengan temperatur di dalam pipa <em>section</em>, hal ini disebabkan karena terjadi <em>heat </em><em>loss</em> pada celah celah ruang di dalam BCH-02 sebelum mencapai pipa <em>section</em>.</p>
An assessment of the value chain of shea in Borgu area of Niger state, Nigeria
Authors: Ali Bwala Madu , Garba Yaru Abdulhamid , Alani Wasiu 
Published: October 2019

This study assessed the value chain of shea in Niger State, Nigeria. One hundred and forty respondents were selected through a multistage random technique. Data were analyzed using value addition method and descriptive statistics. Findings revealed that there are four key players in the shea value chain, namely the sole picker, the processor/picker, butter marketer and the retailer. Regarding value addition, it was found that the sole picker adds a value of ₦250 (3.10%), the local processor, adds a value of ₦1550 (19.38%), the shea butter marketer adds ₦600 (7.70%) and the retailer adds a value of ₦5600 (70%). Furthermore, findings revealed that the retailer has the highest margin of ₦3460 (70.47%) while the processor has a margin of ₦1050 (21.38%). The sole picker has the lowest margin of ₦150 among players in the chain. However, findings reveal that, the picker has a higher margin when he doubles as a processor. Since majority of the pickers and processors are women, empowerment of the female gender can be enhanced through interventions in the shea value chain. Therefore, this study recommends a gender-based study of the shea value chain in the study area which will further reveal potentialities for empowering women and the household in the study area. Furthermore, to give leverage to the sole picker in terms of the size of market margin attracted, it may be expedient to empower the sole picker to get involved in the processing of the nuts.
J Bangladesh Agril Univ 17(3): 369–374, 2019
Selecting Appropriate Cotton Based Cropping Pattern for Increasing Cropping Intensity in Bangladesh
Authors: Kundu S , Hassan K , Alam SMJB , Uddin MF 
Published: October 2019

The experiment was conducted at Cotton Research, Training and Seed Multiplication Farm, Jagodishpur, Chowgacha, Jessore initiated June 19, 2015 for the cropping season 2015-16 to observe the performance of cotton based cropping system including total three crops in a year. The other crops were i) relay wheat – mungbean and ii) relay lentil – mungbean. Four cotton varieties CB-12, CB-13, CB-14 and CB Hybrid-1 were sowed in a RCBD design with three replications. Seed cotton yield was significantly different among the varieties. The highest seed cotton yield (2519.3 kg/ha) was obtained from CB Hybrid-1 and the lowest (2112.37 kg/ha) seed cotton was produced by CB-13. The highest BCR (1.31) was observed in cotton (CB Hybrid-1) –relay lentil –mungbean cropping pattern and the lowest BCR (1.10) was observed in Cotton (CB-13) – relay wheat –mungbean cropping pattern. The finding infers that cotton – relay lentil - mungbean cropping pattern might have the potentiality to increase cropping intensity in Bangladesh.
J. Environ. Sci. & Natural Resources, 11(1-2): 37-41 2018
Management of Soil Resources for Sustainable Development under a Changing Climate
Authors: Jahangir MMR , Jahan I , Mumu NJ 
Published: October 2019

Development was conventionally driven by one particular need, without fully considering the wider or future impacts. This kind of approach has now been considered to be responsible for the economic and environmental catastrophes that humans are facing: from large scale financial crises caused by irresponsible banking to the changes in global climate resulting from our dependence on fossil fuel based energy sources. Soils provide essential ecosystem services such as primary production, regulation of biogeochemical cycles (with consequences for the climate), water filtration, resistance to diseases and pests, and regulation of above-ground biodiversity. Changing of the climate systems is unequivocal. Adaptation to global climate change through improved soil quality by adoption of improved management practices is key to maintaining sustainable agricultural production. A holistic approach to soil management as the engine for increasing productivity by increasing resource use efficiency and making agriculture environmentally compatible is more important than ever before. Strategies of greenhouse gas emission reduction include those that increase the use efficiency of inputs. Herein, we discussed how management and protection of soil resources can contribute to sustainable development through sustainable agricultural production while maintaining sustenance of soil fertility.
J. Environ. Sci. & Natural Resources, 11(1-2): 159-170 2018
Analysis of Drought in the Northern Region of Bangladesh Using Standardized Precipitation Index (SPI)
Authors: Afrin R , Hossain F , Mamun SA 
Published: October 2019

Drought is an extended period when a region notes a deficiency in its water supply. The Standardized Precipitation Index (SPI) method was used in this study to analyze drought. Northern region of Bangladesh was the area of study. Monthly rainfall data of northern region of Bangladesh was obtained from the Meteorological Department of Bangladesh. Obtained rainfall data was from 1991 to 2011 and values from 2012 to 2026 were generated using Markov model. Then SPI values from 1991 to 2026 were calculated by using SPI formula for analyzing drought. Analysis with SPI method showed that droughts in northern region of Bangladesh varied from moderately dry to severely dry conditions and it may vary from moderately dry to severely dry conditions normally in future but in some cases extreme drought may also take place. From the study, it is observed that the northern region of Bangladesh has already experienced severe drought in 1991, 1992, 1994, 1995, 1997, 1998, 2000, 2003, 2005, 2007, 2009 and 2010. The region may experience severe drought in 2012, 2015, 2016, 2018, 2019, 2021, 2022, 2023, 2024, 2025 and 2026 and extreme drought in 2012, 2014, 2016, 2023 and 2024.
J. Environ. Sci. & Natural Resources, 11(1-2): 199-216 2018
Impact of Plant Spacing on Population Dynamics of Sucking Pest of Cotton
Authors: Momtaz MB , Yeasmin K , Khatun MR , Ahmad M 
Published: October 2019

The present study was carried out to find out the impact of plant spacing on population dynamics of sucking pest of cotton from June 2018 to February 2019. The main objectives of the study are to observe the population dynamics of jassid and whitefly under different plant population. The experiment was laid out in RCB design with three replications and five differents treatments viz.,T1- 90x45 cm T2 – 90x40 cm, T3- 90x35 cm, T4- 90x30 cm, T5 – 90X25 cm. The results revealed that peak population of jassid was recorded in last July to October and whitefly from august to October. Plant spacing showed a significant effect on the jassid population. It is clear from the results that maximum population of jassid (32.4), aphids (11.3) and whitefly (18.1) were recorded to be per leaf from those plots where minimum plant spacing (25 cm) was maintained. No of sucking insects were increasing with decreasing plant population.
J. Environ. Sci. & Natural Resources, 11(1-2): 241-243 2018
Pengaruh Pembelajaran Strategi Aptitude Treatment Interaction Terhadap Motivasi dan Hasil Belajar Fisika
Authors: Dappa Ferindandus , Suswati Lis , Rahmawati Eka 
Published: October 2019

Telah dilakukan penelitian dikelas XI SMA Negeri 2 Kota Bima Tahun Pelajaran 2018/2019 dengan tujuan untuk mengetahui perbedaan motivasi dan hasil belajar siswa dengan menggunakan strategi Aptitude Treatment Interaction (ATI) SMA Negeri 2 Kota Bima Tahun Pelajaran 2018/2019. Berdasarkan analisis data dengan menggunakan uji t atau test dapat disimpulkan perbedaan motivasi dan hasil belajar siswa dengan menggunakan strategi Aptitude Treatment Interaction (ATI) SMA Negeri 2 Kota Bima Tahun Pelajaran 2018/2019. Hal ini dibuktikan dengan uji hipotesis yang menunjukkan hipotesis nol (Ho) ditolak dan hipotesis alternative (Ha) diterima atau dengan kata lain, nilai t -hitung lebih besar dari t tabel pada taraf signifikan 5% atau taraf kepercayaan 95%. Dari hasil perhitungan motivasi belajar diperoleh bahwa nilai thitung sebesar 6.07180594 dan nilai ttabel sebesar 1.67468915atau thitung ttabel maka dalam hal ini H0 ditolak dan Ha diterima. Sedangkan pada perhitungan uji hipotesis hasil belajar juga diperoleh hasil thitung = 5.1261 dan nilai ttabel sebesar 1.6747, atau thitung ttabel maka dalam hal ini Ho diterima dan Ha ditolak. Meskipun diterima pada taraf kepercayaan 90%, akan tetapi terdapat kemungkinan ada kesalahan 5%. Kesalahan tersebut, dimungkin berasal dari kurang optimalnya pelaksanan langkah-langkah pembelajaran. Bertolak dari hasil penelitian dan kesimpulan dalam studi kuantitatif ini maka disarankan pada guru kelas XI SMA Negeri 2 Kota Bima hendaknya guru dapat menentukan model/strategi pembelajaran yang tepat sehingga siswa mampu menerima pelajaran yang diberikan dengan baik sehingga akan lebih berminat dan bersemangat. Guru dapat memberikan latihan-latihan soal untuk merangsang motivasi dan hasil belajar baik dirumah maupun disekolah. Disarkan bagi para peneliti selanjutnya, agar lebih dapat mengoptimalkan dan mengembangkan model/strategi pembelajaran Aptitude Treatment Interaction (ATI) dalam setiap pembelajaran
PEMBANGUNAN SISTEM DASHBOARD HUMAN RESOURCES UNTUK PEMANTAUAN KINERJA KARYAWAN PT X BERBASIS WEB
Authors: Putri Ilafi Firsta , Nuryani Maudy , Sari Yustiana 
Published: October 2019

PT X merupakan salah satu perusahaan tambang terbesar di Indonesia. Sebagai perusahaan yang terus berkembang, Departemen Human Resources (HR) pada perushaan tersebut harus dapat mengelola semua informasi karyawan dan bisa memantau kinerja karyawan. HR masih menggunakan Microsoft excel sebagai penyajian informasi secara visual di dalam sistem manajemen kinerja. Hal tersebut akan menjadi suatu kesulitan pada proses pengelolaan informasi dan evaluasi kinerja yang terkait dengan karyawan. Untuk membantu proses rekayasa ulang sistem perusahaan membutuhkan sistem komputerisasi dan terintegrasi yang baik, sehingga informasi dapat disajikan dengan baik ke semua user dan perusahaan mendapatkan informasi yang akurat. Dalam meningkatkan proses pemantauan, memerlukan data dan informasi yang diambil dari seluruh bagian departemen. Penulis membangun sistem dashboard berbasis web dalam penyajian informasi dan untuk pemantauan kinerja karyawan. Dashboard ini digunakan oleh Departemen Human Resources (HRD). Sistem dashboard dibangun menggunakan framework bootstrap. Dengan adanya sistem dashboard human resources berbasis web akan mempermudah dalam menyajikan informasi tentang karyawan.
Keywords : Dashboard, Human Resources, Pemantauan
PEMBUATAN PENDETEKSI OBYEK DENGAN METODE YOU ONLY LOOK ONCE (YOLO) UNTUK AUTOMATED TELLER MACHINE (ATM)
Authors: Wasril Abi Rachman , Ghozali Mohammad Shiddiq , Mustafa M Banu 
Published: October 2019

Perkembangan Teknologi Informasi dan Komunikasi begitu pesat di zaman sekarang ini. Diikuti pula dengan perkembangan di bidang Artificial Intelligence (AI) atau Kecerdasan Buatan. Di Indonesia sendiri masih belum begitu populer dikalangan masyarakat akan tetapi perusahaan-perusahaan IT berlomba-lomba menciptakan inovasi dibidang Kecerdasan Buatan dan penerapan Kecerdasan Buatan disegala aspek kehidupan. Contoh kasus di Automated Teller Machine (ATM), seringkali terjadi kejahatan di ATM seperti pengintaian nomor pin, skimming, lebanese loop dan kejahatan lainnya. Walaupun di ATM sudah terdapat CCTV akan tetapi penjahat menggunakan alat bantu untuk menutupi wajahnya seperti helm, topi, masker dan kacamata hitam. Biasanya didepan pintu masuk ATM terpampang larangan untuk tidak menggunakan helm, topi, masker dan kacamata hitam serta tidak membawa rokok. Akan tetapi larangan itu masih tetap ada yang melanggar, dikarenakan tidak ada tindak lanjut ketika seseorang menggunakan benda-benda yang dilarang dibawa kedalam ATM. Oleh karena itu penulis membuat sistem pendeteksi obyek di bidang Kecerdasan Buatan untuk mendeteksi benda-benda yang dilarang digunakan ketika berada di ATM. Salah satu metode yang digunakan untuk menciptakan Object Detection yaitu You Only Look Once (YOLO). Implementasi ide ini tersedia pada DARKNET (open source neural network). Cara kerja YOLO yaitu dengan melihat seluruh gambar sekali, kemudian melewati jaringan saraf sekali langsung mendeteksi object yang ada. Oleh karena itu disebut You Only Look Once (YOLO). Pada penelitian ini, penulis membuat sistem yang masih dalam bentuk pengembangan, sehingga menjalankannya masih menggunakan command prompt.
Keywords : Automated Teller Machine (ATM), Kecerdasan Buatan, Pendeteksi Obyek, You Only Look Once (YOLO)
Scheelite et cassitérite dans la « granulite » de La Capelle-Bleys (Aveyron)
Authors: Fortuné Jean-Pol , Tollon Francis 
Published: October 2019

A new scheelite « granulite » deposit has been recently discovered in the La Capelle-Bleys (Aveyron). Scheelite associated with cassiterite and wolframite is situated in a very strongly mylonitised N-S zone. E-W veins of quartz intercross with the former and contain a paragenese of low temperature. An analogy to that of Montredon-Labessonié is likely possible.