bluuebunny/crossref_metadata_2025_split huggingface dataset:
T-Cell Deletion of MyD88 Connects IL17 and IκBζ to RAS Oncogenesis
Authors: Cataisson Christophe , Salcedo Rosalba , Michalowski Aleksandra M. , Klosterman Mary , Naik Shruti , Li Luowei , Pan Michelle J. , Sweet Amalia , Chen Jin-Qiu , Kostecka Laurie G. , Karwan Megan , Smith Loretta , Dai Ren-Ming , Stewart C. Andrew , Lyakh Lyudmila , Hsieh Wang-Ting , Khan Asra , Yang Howard , Lee Maxwell , Trinchieri Giorgio , Yuspa Stuart H. 
Published: June 2019

Abstract

Cancer development requires a favorable tissue microenvironment. By deleting Myd88 in keratinocytes or specific bone marrow subpopulations in oncogenic RAS-mediated skin carcinogenesis, we show that IL17 from infiltrating T cells and IκBζ signaling in keratinocytes are essential to produce a permissive microenvironment and tumor formation. Both normal and RAS-transformed keratinocytes respond to tumor promoters by activating canonical NF-κB and IκBζ signaling, releasing specific cytokines and chemokines that attract Th17 cells through MyD88-dependent signaling in T cells. The release of IL17 into the microenvironment elevates IκBζ in normal and RAS-transformed keratinocytes. Activation of IκBζ signaling is required for the expression of specific promoting factors induced by IL17 in normal keratinocytes and constitutively expressed in RAS-initiated keratinocytes. Deletion of Nfkbiz in keratinocytes impairs RAS-mediated benign tumor formation. Transcriptional profiling and gene set enrichment analysis of IκBζ−deficient RAS-initiated keratinocytes indicate that IκBζ signaling is common for RAS transformation of multiple epithelial cancers. Probing The Cancer Genome Atlas datasets using this transcriptional profile indicates that reduction of IκBζ signaling during cancer progression associates with poor prognosis in RAS-driven human cancers.

Implications:
The paradox that elevation of IκBζ and stimulation of IκBζ signaling through tumor extrinsic factors is required for RAS-mediated benign tumor formation while relative IκBζ expression is reduced in advanced cancers with poor prognosis implies that tumor cells switch from microenvironmental dependency early in carcinogenesis to cell-autonomous pathways during cancer progression.
Tumor Cells Hijack Macrophage-Produced Complement C1q to Promote Tumor Growth
Authors: Roumenina Lubka T. , Daugan Marie V. , Noé Rémi , Petitprez Florent , Vano Yann A. , Sanchez-Salas Rafaël , Becht Etienne , Meilleroux Julie , Clec'h Bénédicte Le , Giraldo Nicolas A. , Merle Nicolas S. , Sun Cheng-Ming , Verkarre Virginie , Validire Pierre , Selves Janick , Lacroix Laetitia , Delfour Olivier , Vandenberghe Isabelle , Thuilliez Celine , Keddani Sonia , Sakhi Imene B. , Barret Eric , Ferré Pierre , Corvaïa Nathalie , Passioukov Alexandre , Chetaille Eric , Botto Marina , de Reynies Aurélien , Oudard Stephane Marie , Mejean Arnaud , Cathelineau Xavier , Sautès-Fridman Catherine , Fridman Wolf H. 
Published: June 2019

AbstractClear-cell renal cell carcinoma (ccRCC) possesses an unmet medical need, particularly at the metastatic stage, when surgery is ineffective. Complement is a key factor in tissue inflammation, favoring cancer progression through the production of complement component 5a (C5a). However, the activation pathways that generate C5a in tumors remain obscure. By data mining, we identified ccRCC as a cancer type expressing concomitantly high expression of the components that are part of the classical complement pathway. To understand how the complement cascade is activated in ccRCC and impacts patients' clinical outcome, primary tumors from three patient cohorts (n = 106, 154, and 43), ccRCC cell lines, and tumor models in complement-deficient mice were used. High densities of cells producing classical complement pathway components C1q and C4 and the presence of C4 activation fragment deposits in primary tumors correlated with poor prognosis. The in situ orchestrated production of C1q by tumor-associated macrophages (TAM) and C1r, C1s, C4, and C3 by tumor cells associated with IgG deposits, led to C1 complex assembly, and complement activation. Accordingly, mice deficient in C1q, C4, or C3 displayed decreased tumor growth. However, the ccRCC tumors infiltrated with high densities of C1q-producing TAMs exhibited an immunosuppressed microenvironment, characterized by high expression of immune checkpoints (i.e., PD-1, Lag-3, PD-L1, and PD-L2). Our data have identified the classical complement pathway as a key inflammatory mechanism activated by the cooperation between tumor cells and TAMs, favoring cancer progression, and highlight potential therapeutic targets to restore an efficient immune reaction to cancer.
Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA
Authors: Kundu Kiran , Ghosh Susmita , Sarkar Rhitajit , Edri Avishay , Brusilovsky Michael , Gershoni-Yahalom Orly , Yossef Rami , Shemesh Avishai , Soria Jean-Charles , Lazar Vladimir , Joshua Ben-Zion , Campbell Kerry S. , Elkabets Moshe , Porgador Angel 
Published: June 2019

Abstract
mAb-based blocking of the immune checkpoints involving the CTLA4-B7 and PD1-PDL1 inhibitory axes enhance T-cell–based adaptive immune responses in patients with cancer. We show here that antitumor responses by natural killer (NK) cells can be enhanced by a checkpoint-blocking mAb, 14-25-9, which we developed against proliferating cell nuclear antigen (PCNA). PCNA is expressed on the surface of cancer cells and acts as an inhibitory ligand for the NK-cell receptor, NKp44-isoform1. We tested for cytoplasmic- and membrane-associated PCNA by FACS- and ImageStream-based staining of cell lines and IHC of human cancer formalin fixed, paraffin embedded tissues. The mAb, 14-25-9, inhibited binding of chimeric NKp44 receptor to PCNA and mostly stained the cytoplasm and membrane of tumor cells, whereas commercial antibody (clone PC10) stained nuclear PCNA. NK functions were measured using ELISA-based IFNγ secretion assays and FACS-based killing assays. The NK92-NKp44-1 cell line and primary human NK cells showed increased IFNγ release upon coincubation with mAb 14-25-9 and various solid tumor cell lines and leukemias. Treatment with 14-25-9 also increased NK cytotoxic activity. In vivo efficacy was evaluated on patient-derived xenografts (PDX)-bearing NSG mice. In PDX-bearing mice, intravenous administration of mAb 14-25-9 increased degranulation (CD107a expression) of intratumorally injected patient autologous or allogeneic NK cells, as well as inhibited tumor growth when treated long term. Our study describes a mAb against the NKp44-PCNA innate immune checkpoint that can enhance NK-cell antitumor activity both in vitro and in vivo.
Après la Physique Ionienne et la Physique du XXe siècle
Authors: Pin Víctor Gomez 
Published: June 2019

In lieu of an abstract, here is a brief excerpt of the content:
"Pour mettre en relief la difficulté que l’on a parfois à cataloguer la philosophie dans le cadre des disciplines académiques, j’ai souvent utilisé un apologue : si on demande à un étudiant de chimie ou de philologie latine de décrire ce que l’on fait concrètement pendant son heure de cours, il s’en tirera sans trop de trouble. Demandons la même chose à l’étudiant qui se dirige vers son cours d’Ontologie ou même de Théorie de la Connaissance. Il aura la plus grande difficulté à expliquer au profane curieux à quoi il va occuper son temps, quelle sera non seulement sa propre tâche mais aussi celle de son professeur."
Le Langage est un Monde
Authors: Santos Luiz Henrique Lopes dos 
Published: June 2019

In lieu of an abstract, here is a brief excerpt of the content:
"Il est déjà passé le temps où la philosophie s’occupait fièrement des choses elles-mêmes. Cette constatation (d’ailleurs historiquement incontestable), le diagnostic de la situation à laquelle elle se réfère et la soumission volontaire à ses conséquences jettent les bases du programme philosophique que Francis Wolff s’est proposé d’accomplir dans Dire le monde."
Comprendre Pourquoi J’Agis
Authors: Malinge Yoann 
Published: June 2019

In lieu of an abstract, here is a brief excerpt of the content:
"'De deux choses l’une : ou [la personne qui agit] est une personne, elle demeure la même, et ses actes expliquent entièrement ce qu’elle est ; ou ses actes peuvent toujours être interrogés comme des événements du monde, et elle n’est jamais la même qu’elle-même. Car inversement, l’acte est d’autant plus un vrai acte (et non un simple événement naturel du monde) qu’il ne surgit pas de ce que sont les choses, mais change la face du monde. Il est lui-même cette face changée du monde' [Francis Wolff, Dire le monde].
Telle est l’antinomie de la relation de l’agent à son action que décrit Francis Wolff dans le troisième chapitre de Dire le monde.Pour penser l’action, il faut concevoir dans le même mouvement un agent qui soit la cause de l’action sans que cette action soit l’effet de ce qu’est l’agent. La solution que Francis Wolff fournit à l’antinomie, dans le quatrième chapitre de Dire le monde, repose sur le « je » et sur le concept de « j’agis ». Il ne s’agit pas ici d’en faire le commentaire, mais de trouver dans cette résolution une source d’inspiration pour envisager la conscience de l’agent lorsqu’il agit."
Un Monde Contradictoire est-il Possible ?
Authors: Moulines Carlos Ulises 
Published: June 2019

In lieu of an abstract, here is a brief excerpt of the content:
"Dans Dire le monde, Francis Wolff développe une conception ontologique qui combine, de manière originale, quelques catégories traditionnelles de la métaphysique avec des notions et principes de la philosophie analytique contemporaine, et tout particulièrement de la philosophie du langage. Je connais très peu de philosophes contemporains qui soient capables de combiner ces deux grandes traditions philosophiques d’une manière si prometteuse pour analyser (et résoudre !) quelques- unes des questions ontologiques les plus difficiles. Francis Wolff en est capable, d’abord parce que, par sa formation, il connaît très bien les deux traditions, mais surtout parce qu’il ne veut pas se limiter à une exégèse plus ou moins bien fondée des idées d’autres auteurs du passé ou du présent : il veut surtout établir et défendre sa propre réponse à la question ontologique de toujours : « Qu’y a-t-il ? »."
Réflexion et Réflexivité
Authors: Recanati François 
Published: June 2019

In lieu of an abstract, here is a brief excerpt of the content:
"Étymologiquement, pour autant que je sache, la notion première de réflexion est la notion physique ; une vitre, par exemple, réfléchit les rayons du soleil. La physique étudie cela, comme elle étudie la trajectoire mécanique d’une boule de billard qui sert ici de modèle. Quel rapport entre cette réflexion (la réflexion optique) et celle qui nous importe à nous, philosophes ? Je pense que le lien est fourni par un type particulier de réflexion optique, à savoir la réflexion spéculaire. Les miroirs réfléchissent la lumière, et quand ils le font, le miroir renvoie à l’observateur l’image symétrique inversée de ce qui se trouve devant le miroir (typiquement l’observateur lui-même). Je regarde dans le miroir, et je me vois ! Dans le phénomène spéculaire, nous trouvons ce qui est au cœur de la ou des notion(s) non plus physique(s) mais mentale(s) de réflexion : la notion philosophique, et aussi la notion ordinaire (comme lorsqu’on dit de quelqu’un qu’il réfléchit, ou lorsqu’on propose des réflexions sur un sujet donné). Ce qui caractérise la réflexion mentale, sous toutes ses formes, est quelque chose que l’on retrouve aussi dans la réflexion spéculaire et qui fait que celle-ci sert souvent de modèle pour la réflexion mentale : c’est la réflexivité."
La Sagesse de la Multitude
Authors: Girard Charles 
Published: June 2019

In lieu of an abstract, here is a brief excerpt of the content:
"L’objection la plus ancienne et la plus redoutable à la démocratie fait valoir que le gouvernement par le peuple dessert le gouvernement pour le peuple. Les citoyens manquant pour la plupart de sagesse ou de compétence, le bien commun serait mieux assuré en confiant le pouvoir à un individu éclairé ou à une élite experte. Une réponse commune à cette objection concède la prémisse mais affirme la priorité au gouvernement par le peuple sur le gouvernement pour le peuple : le droit égal à la participation devrait l’emporter sur la promotion de la compétence, même si celle-ci est requise par le bon gouvernement. La démocratie se trouve alors réduite à un ensemble de procédures équitables, traitant les citoyens en égaux ; elle ne se définit plus par la poursuite du bien commun. Il est toutefois une autre réponse à l’objection, qui évite cette dérive vers un procéduralisme étroit. Elle consiste à nier la prémisse et à affirmer la sagesse politique du peuple. Il n’est pas vrai que le gouvernement pour le peuple serait mieux assuré en confiant le pouvoir à un petit nombre de sages ou d’experts, fussent-ils les meilleurs parmi les citoyens. Cette thèse remarquable peut paraître improbable. Sa défense peut pourtant s’appuyer sur l’un des arguments les plus intrigants élaborés par la philosophie politique aristotélicienne, qui inspire et éclaire les controverses philosophiques contemporaines sur la valeur du régime démocratique : l’argument de la sagesse de la multitude."
La Corrida
Authors: Guillaume-Alonso Araceli 
Published: June 2019

In lieu of an abstract, here is a brief excerpt of the content:
"Les origines de la tauromachie remontent à la nuit des temps. Rite de fécondité, mythe, fête rurale, rite de passage, exercice cynégétique, spectacle urbain, joute aristocratique, jeu collectif ou exploit individuel, ... Le face-à-face entre l’homme et le taureau a pris au long des siècles des formes très diverses, dans un double processus de transformation et de fusion qui a abouti à la corrida moderne.C’est à l’aube de la modernité, à la charnière entre les XVe et XVIe siècles, que la fête taurine-spectacle, ancêtre de la corrida, dessine ses contours à partir de pratiques taurines très diverses, présentes sur une large géographie ibérique et dont certaines variantes s’étendent même au nord des Pyrénées."
Lieux de Francis Wolff
Authors: Salanskis Jean-Michel 
Published: June 2019

In lieu of an abstract, here is a brief excerpt of the content:
"Avec Francis Wolff, j’ai d’abord eu le sentiment d’une affinité, qui au fil des années a pris pour moi le visage d’une complicité. Pour le dire simplement, je le percevais comme un des rares qui fût réellement tolérant à l’égard des nombreuses manières de faire de la philosophie : j’entends ici tolérant non seulement au sens de celui qui n’a pas le projet de moquer ou calomnier les autres – ceux qui écrivent autrement, qui ont une autre bibliothèque de référence – mais au sens de celui qui entend et comprend le génie de plusieurs démarches, extrêmement différentes, et même s’il ne leur adhère pas. À vrai dire et par parenthèse, il est triste de l’observer, fort rares sont de nos jours dans la communauté philosophique ceux à qui il est facile de concéder que des gens travaillant tout à fait en dehors d’eux, sans intersection avec aucune de leurs écuries, sont excellents."
La Méthode de Symétrie chez Francis Wolff
Authors: Sève Bernard 
Published: June 2019

In lieu of an abstract, here is a brief excerpt of the content:
"Il y a des jardins à la française et il y a des jardins à l’anglaise. Les jardins à la française sont marqués par l’ordre, la symétrie, l’équilibre des plans et des volumes, la régularité des chemins qui obéissent à une pensée maîtrisée et qui présentent esthétiquement cette maîtrise. Les jardins à l’anglaise sont marqués par la dissymétrie, le déséquilibre des plans et des volumes, l’irrégularité de chemins tortueux dont on ne sait où ils mènent ; c’est un désordre étudié, et qui doit dissimuler l’artifice supérieur dont il est le produit, selon le principe « l’art cache l’art ». Il y a des livres qui ressemblent à des jardins à l’anglaise, avec leurs parcours sinueux, leurs caprices, leurs raisonnements esquissés mais inaboutis, leur désordre étudié, la dissimulation de la rhétorique subtile qui les commande en sous-œuvre. Et puis il y a des livres qui ressemblent à des jardins à la française, marqués par l’ordre, la symétrie, l’équilibre, la régularité, la cohérence et je dirais la probité de la pensée. Les chemins sont nets, et, même lorsqu’ils font de complexes et savants détours, on sait d’où l’on vient et on sait où l’on va."
What You Say and How You Say it: Joint Modeling of Topics and Discourse in Microblog Conversations
Authors: Zeng Jichuan , Li Jing , He Yulan , Gao Cuiyun , Lyu Michael R. , King Irwin 
Published: June 2019

This paper presents an unsupervised framework for jointly modeling topic content and discourse behavior in microblog conversations. Concretely, we propose a neural model to discover word clusters indicating what a conversation concerns (i.e., topics) and those reflecting how participants voice their opinions (i.e., discourse).1Extensive experiments show that our model can yield both coherent topics and meaningful discourse behavior. Further study shows that our topic and discourse representations can benefit the classification of microblog messages, especially when they are jointly trained with the classifier.Our data sets and code are available at: http://github.com/zengjichuan/Topic_Disc .
DISRUPTED SOCIETIES, TRANSFORMATIVE STATES: POLITICS OF LAW AND GENDER IN REPUBLICAN TURKEY AND IRAN
Authors: Halper Louise 
Published: June 2019

AbstractIran and Turkey, one an Islamic, the other a secular republic, are the more successful loci of women's participation in public life, both politically and economically, than are a number of other states whose population is largely Muslim. I suggest their relative success (as measured by World Bank and UNHDR data) may be due to similar transformative shifts from monarchy to republic. Historical examination of the cases of Turkey and Iran suggests that while the mobilization of women into political activity is crucial, it need not result in similar legal changes. Obviously, the right to vote is fundamental to political participation and exists for women in both countries. The comparison of the two republics suggests that, at least in Muslim-majority countries, a legal regime explicitly protecting gender rights may be less central to social change, including women's participation in public life, than is a history of women's mobilization in support of popular politics.
Minorities and Statelessness: Social Exclusion and Citizenship in Cambodia
Authors: Sperfeldt Christoph 
Published: June 2019

Abstract
More than 75 per cent of the world’s known stateless belong to minorities. Building upon ethnographic research conducted between 2008–2017, this paper considers the case of ethnic Vietnamese minority populations in Cambodia. Members of this group are long-term residents, having been born and raised in the country for generations, with the exception of the period during the Khmer Rouge regime when they were forcibly deported to Vietnam. Since their return to Cambodia in the early 1980s, individuals from this group have been regarded by Cambodian authorities as ‘immigrants’. This paper examines how discriminatory policies, laws and administrative practices regulate individual and collective identities, while creating categories that determine social inclusion and exclusion. In doing so, this paper makes visible the ambivalence of law and rights – both as tools for the construction of exclusionary citizenship, but also as instruments which minorities to contest their social exclusion.
Il corpo dell’auleta
Authors: Dolazza Anna 
Published: June 2019

The versatility of the aulos is passed on to the musician, who in turn is transformed into a physical representation of the instrument’s sound. With the precious aid of book iv of Pollux’s Onomasticon it is possible to reconstruct the special set of vocabulary linked to the sound of the aulos. If it could already in itself be considered as ἐπαγωγόν, the additional effect of the movements, gestures, and facial expressions of the aulete resulted in a strong visual, as well as emotional, impact. Nor can we forget, on the other hand, the less than favorable judgments, abundant in philosophical texts, that arose in regard to auletic performances: just as certain physiognomic traits of the aulos are to blame, so too are certain bodily movements of the aulete: almost as if the negative characteristics are passed reciprocally from instrument to musician in a sort of circular breathing.
La versatilità dell’aulos si trasmette all’esecutore, che durante la performance diviene così immagine fisica e concreta del suono percepito. Con il prezioso ausilio del libro iv dell’Onomasticon di Giulio Polluce è possibile ricostruire il campo semantico legato alla produzione del suono auletico. Se esso poteva già di per sé essere avvertito come ἐπαγωγόν, inoltre, i movimenti, i gesti e le espressioni facciali dell’auleta risultavano di forte impatto visivo, oltre che emotivo. Non ci si può dimenticare, d’altro canto, dei giudizi poco benigni, affioranti soprattutto dai testi filosofici, in merito alla pratica auletica: come alcuni tratti della fisionomia dell’aulos, così anche alcuni atteggiamenti del corpo dell’auleta sono biasimevoli, quasi che le caratteristiche negative passino vicendevolmente da strumento a esecutore in una sorta di respirazione circolare.
This article is in Italian.
Tibia and Tuba at the Crossroads of Funerary and Nuptial Imagery
Authors: Wyslucha Kamila 
Published: June 2019

Abstract
References to music in poetry often play a genre-defining role. This is the case in Propertius 2.7 and Ovid Heroides 12, which employ the tibia and tuba in the topos of a mournful wedding. While the pipes belong to the motivic repertoire of elegy, where they usually occur in plaintive contexts, the introduction of the funeral trumpet to an elegiac motif is an innovation, reflecting traditional uses of the instrument during burial rituals. The wedding tibia is also represented in its authentic performative context, but the joyous character of its tunes is rendered more sorrowful than funeral music, and thus in keeping with conventional portrayals of the instrument in elegy. On the other hand, the representation of the tuba in this motif stands in opposition to other literary depictions, which usually place the clamorous sound and military, rather than funerary, uses of the instrument in the foreground. In consequence of this thematic innovation, the funeral trumpet not only becomes part of a mournful wedding topos but also a ‘genre-appropriate’ instrument in elegy.
Ἀνωνύµου σύγγραµµα περὶ µουσικῆς (Anonymi Bellermann)
Authors: Pöhlmann Egert 
Published: June 2019

Abstract
In 1841, Friedrich Bellermann published two treatises about Greek music, the Anonymi scriptio de musica and Bacchii senioris introductio artis musicae (Bellermann 1841). While the second treatise belongs to some Dionysius, a Byzantine musicologist of the time of Constantine Porphyrogenetos (912-959; new edition Tertsēs 2010), the first treatise is an agglomeration of five musical handbooks (new edition Najock 1972 and 1975). The available manuscript tradition of the respective headings and the beginnings and the content of the different components make it possible to disentangle the alleged σύγγραµµα into its parts and to describe the original treatises accurately.
The Koinē Hormasia Re-Interpreted
Authors: Najock Dietmar 
Published: June 2019

Abstract
The hormasia-table is preserved in a manuscript from 1040 ad. The heart or kernel of the table (two columns, each with 16 Hypolydian notes) was probably established in antiquity in order to provide a mean-tone tuning and a basic system for playing two voices on the harp (or the organ): a given melody with the right hand and a more or less schematic accompaniment with the left. In Byzantine times, the system was probably used as a stringing plan for doubly registered psalteries, both of the rectangular and the harp-like type.