bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of recommended posttreatment services for adolescent and young adult survivors of Hodgkin lymphoma
Authors: Hahn Erin E. , Wu Yi‐Lin , Munoz‐Plaza Corrine E. , Garcia Delgadillo Jazmine , Cooper Robert M. , Chao Chun R. 
Published: January 2019

AbstractBackgroundHodgkin lymphoma (HL) is a leading cancer diagnosis for adolescents and young adults (AYAs), with an overall 5‐year survival rate of >80%. However, to the authors’ knowledge, little is known regarding posttreatment patterns of care. In the current study, the authors characterized the use of guideline‐recommended services in a cohort of AYA survivors of HL in Kaiser Permanente Southern California.MethodsPatients with HL who were diagnosed between ages 15 and 39 years between 2000 and 2010 were identified. The authors calculated the number of patients who received recommended short‐term care within 2 years after treatment cessation for those who remained enrolled and alive from 2001 through 2015. Use of recommended late‐effects screening for breast cancer and cardiovascular disease was examined. Logistic regression was used to evaluate the association between receipt of recommended care and patient, cancer, and treatment characteristics.ResultsA total of 354 patients were identified, with a mean age at the time of diagnosis of 26 years (standard deviation, 6.9 years). Approximately 12% of patients had stage I disease, 59% had stage II disease, 17% had stage III disease, and 13% of patients had stage IV disease. Nearly all patients received chemotherapy (95%), 51% received radiotherapy, and 5% received care from a pediatric oncologist. Overall, approximately 49% of patients received recommended short‐term care. Of those patients eligible for cardiovascular screening at 10 years posttreatment (60 patients), 53% received at least 1 screening. Of those patients eligible for breast cancer screening (21 patients), approximately 50% underwent at least 1 screening. Regression results indicated that those patients treated by a pediatric oncologist were >3 times as likely to receive recommended short‐term care.ConclusionsThe results of the current study highlight gaps in the delivery of posttreatment care to AYA survivors of HL. By determining areas in need of improvement, these findings can guide the development of tailored interventions with which to improve care.
Centrifuged supernatants from FNA provide a liquid biopsy option for clinical next‐generation sequencing of thyroid nodules
Authors: Ye Wenrui , Hannigan Brette , Zalles Stephanie , Mehrotra Meenakshi , Barkoh Bedia A. , Williams Michelle D. , Cabanillas Maria E. , Edeiken‐Monroe Beth , Hu Peter , Duose Dzifa , Wistuba Ignacio I. , Medeiros L. Jeffrey , Stewart John , Luthra Rajyalakshmi , Roy‐Chowdhuri Sinchita 
Published: January 2019

BackgroundMolecular testing is recommended as an adjunct to improve the preoperative diagnosis of fine‐needle aspiration (FNA) of thyroid nodules. Centrifuged supernatants from FNA samples, which are typically discarded, have recently emerged as a novel liquid‐based biopsy for molecular testing. This study evaluates the use of thyroid FNA supernatants for detecting clinically relevant mutations.MethodsSupernatants from thyroid FNA samples (n = 156) were evaluated. A 50‐gene next‐generation sequencing (NGS) assay was used, and mutation analysis results from a subset of samples were further compared with those of paired FNA smears and/or cell blocks.ResultsAll 156 samples yielded adequate DNA (median, 135 ng; range, 11‐3180 ng), and 129 of these samples (83%) were successfully sequenced by NGS. The most frequently detected somatic mutations included BRAF and RAS mutations, which were followed by RET, TP53, PTEN, CDKN2A, and PIK3CA mutations. Eleven of 31 cases with an indeterminate cytologic diagnosis and 9 of 12 cases that were suspicious for malignancy had somatic mutations, including the BRAF V600E mutation, which is highly definitive for papillary thyroid carcinoma (PTC). Seven of the 9 indeterminate and suspicious cases with the BRAF V600E mutation had surgical follow‐up, and they were all confirmed to be PTC. A comparison of the mutation profiles derived from supernatants with those of paired smears and/or cell blocks in a small subset of cases (n = 8) showed 100% concordance.ConclusionsThis study provides evidence that FNA supernatants can be used as a surrogate for thyroid molecular testing to improve diagnostic accuracy in indeterminate nodules, provide prognostic/predictive information, and improve overall patient management.
Extrastriate connectivity of the mouse dorsal lateral geniculate thalamic nucleus
Authors: Bienkowski Michael S. , Benavidez Nora L. , Wu Kevin , Gou Lin , Becerra Marlene , Dong Hong‐Wei 
Published: January 2019

AbstractThe mammalian visual system is one of the most well‐studied brain systems. Visual information from the retina is relayed to the dorsal lateral geniculate nucleus of the thalamus (LGd). The LGd then projects topographically to primary visual cortex (VISp) to mediate visual perception. In this view, the VISp is a critical network hub where visual information must traverse LGd–VISp circuits to reach higher order “extrastriate” visual cortices, which surround the VISp on its medial and lateral borders. However, decades of conflicting reports in a variety of mammals support or refute the existence of extrastriate LGd connections that can bypass the VISp. Here, we provide evidence of bidirectional extrastriate connectivity with the mouse LGd. Using small, discrete coinjections of anterograde and retrograde tracers within the thalamus and cortex, our cross‐validated approach identified bidirectional connectivity between LGd and extrastriate visual cortices. We find robust reciprocal connectivity of the medial extrastriate regions with LGd neurons distributed along the “ventral strip” border with the intergeniculate leaflet. In contrast, LGd input to lateral extrastriate regions is sparse, but lateral extrastriate regions return stronger descending projections to localized LGd areas. We show further evidence that axons from lateral extrastriate regions can overlap onto medial extrastriate‐projecting LGd neurons in the ventral strip, providing a putative subcortical LGd pathway for communication between medial and lateral extrastriate regions. Overall, our findings support the existence of extrastriate LGd circuits and provide novel understanding of LGd organization in rodent visual system.
Microgravimetric and Spectroscopic Analysis of Solid−Electrolyte Interphase Formation in Presence of Additives
Authors: Ivanov Svetlozar , Mai Sebastian , Himmerlich Marcel , Dimitrova Anna , Krischok Stefan , Bund Andreas 
Published: January 2019

AbstractElectrochemical quartz crystal microbalance (EQCM) with damping monitoring is applied for real‐time analysis of solid−electrolyte interphase (SEI) formation in diphenyl octyl phosphate (DPOP) and vinylene carbonate (VC) modified electrolytes. Fast SEI formation is observed for the DPOP containing electrolyte, whereas slow growth is detected in VC‐modified and reference electrolytes. QCM measurements in a dry state show considerable reduction of the mass quantity for DPOP and reference samples and minor mass decrease for the SEI layer formed in the presence of VC. The results indicate that VC enhances SEI stability, whereas the addition of DPOP or no additive results in incorporation of loosely attached species, leadubg to SEI instability. Resonance frequency damping, Δw, and dissipation factor, D, are used for analyzing mechanical properties of the SEI layers. The apparent increase of Δw and D during SEI formation in presence of DPOP suggests a pronounced viscoelasticity of the layer. QCM results are compared with surface morphology and chemical composition, revealing excellent agreement of the applied characterization approaches.
What can the gut microbiome teach us about the connections between child physical and mental health? A systematic review
Authors: Kan Janice M. , Cowan Caitlin S. M. , Ooi Chee Y. , Kasparian Nadine A. 
Published: January 2019

AbstractA deeper understanding of the gut–brain axis is of significance in pediatrics, given the influential role of early childhood experiences and exposures in shaping the microbiome, and health, across the life course. This systematic review synthesized evidence on the connection between the gut microbiome and mental health in children with physical illness. Six electronic databases were systematically searched and data extracted according to the Preferred Reporting Items for Systematic reviews and Meta‐Analyses (PRISMA) guidelines. Of 1,476 identified articles, 11 articles reporting on nine unique studies (all randomized controlled trials) were included. Most studies examined the gut microbiome in infants with colic, while the remaining studies investigated outcomes in children aged 1 day to 18 years at risk for atopic dermatitis or irritable bowel syndrome. Baseline and postintervention gut microbiome differences varied across studies. Findings on psychological functioning also varied, with only half of the captured studies showing a positive effect of intervention on psychological well‐being. Only two studies analyzed the association between the gut microbiome and psychological outcomes, each with a different pattern of results. As the field moves forward, it will be critical to gain a better understanding of the microbiome characteristics that influence mental health outcomes in pediatric populations.
Transient modelling of physical habitat for stream macrozoobenthos at intermediate spatial and temporal scales—Moving towards more dynamic descriptions of hydromorphology
Authors: Tatis‐Muvdi Roberto , Stamm Jürgen 
Published: January 2019

AbstractA strategy for modelling the spatiotemporal supply of a physical habitat for stream macrozoobenthos is presented and used to explore the limiting role of hydromorphology on species of varying sensitivity. The approach is based on unsteady numerical two‐dimensional shallow water simulations, which are combined with substrate information and tolerance ranges in order to build unsteady physical habitat models for a group of 13 taxa on the upper course of the river Lahn (Germany). The resulting habitat information aims to capture physical habitat gradients on an intermediate scale that is larger than individual organisms, but smaller than the stream's geomorphic units, as well as to follow hydrological variations determined by the stream's flow regime. By modelling the physical habitat at this spatiotemporal scale, the approach builds on information derived from typical field surveys relating macrozoobenthos and hydromorphology, which are based on quadrat samples placed in different hydraulic zones in the stream (riffles, pools, runs, glides, mid‐channel and shore areas, side arms, cut‐off and slip‐off banks, etc.), and therefore has the advantage of using knowledge thus derived at the same scale it was generated.
Assessing the effect of density on population growth when modeling individual encounter data
Authors: Tenan Simone , Tavecchia Giacomo , Oro Daniel , Pradel Roger 
Published: January 2019

AbstractThe relative role of density‐dependent and density‐independent variation in vital rates and population size remains largely unsolved. Despite its importance to the theory and application of population ecology, and to conservation biology, quantifying the role and strength of density dependence is particularly challenging. We present a hierarchical formulation of the temporal symmetry approach, also known as the Pradel model, that permits estimation of the strength of density dependence from capture–mark–reencounter data. A measure of relative population size is built in the model and serves to detect density dependence directly on population growth rate. The model is also extended to account for temporal random variability in demographic rates, allowing estimation of the temporal variance of population growth rate unexplained by density dependence. We thus present a model‐based approach that enable to test and quantify the effect of density‐dependent and density‐independent factors affecting population fluctuations in a single modeling framework. More generally, we use this modeling framework along with simulated and empirical data to show the value of including density dependence when modeling individual encounter data without the need for auxiliary data.
Study on the change of permeability of gas‐containing coal under many factors
Authors: Wang Fakai , Liang Yunpei , Li Xuelong , Li Lei , Li Jiangong , Chen Yulong 
Published: January 2019

AbstractThe permeability characteristics of gas‐containing coal under different radial stress, different axial stress, and gas pressure were studied by orthogonal experiments, using a self‐developed three‐axis servo fluid infiltration system with a gas‐solid coupling of gas‐containing coal, on the basis of a single‐factor influence on the permeability of gas‐containing coal. By considering the effective stress, three kinds of relationships between permeability and radial stress, permeability and axial stress, as well as permeability and gas pressure were established. The results show that radial stress, axial stress, and gas pressure have a great influence on the permeability characteristics of gas‐containing coal: (a) The influence of radial stress on gas permeability is significant, whereas the influence of axial stress is negligible. The degree of influence of radial stress, gas pressure, and axial stress on the permeability decreases in turn; (b) The permeability decreases following a power function with the increase of the radial stress; (c) The permeability gradually increases with the increase of axial stress. With the increase of axial stress, the permeability increases following a power function; (d) The increase in gas pressure will reduce the effective stress on the coal, and the number of pores and cracks inside the coal body will decrease. This will increase the effective seepage flow and gas flow rate of the gas and eventually lead to the increase of coal permeability. There is a quadratic function relationship between the permeability and gas pressure.
Investigating the fate of copper in a laboratory-based toxicity test with embryos of Mytilus galloprovincialis: Copper mass balance of a closed bioassay
Authors: Zitoun Rebecca , Hassler Christel , Clearwater Susan J. , Thompson Karen J. , Albert Anathea , Sander Sylvia G. 
Published: January 2019

Abstract

The production of accurate and reliable data on metal toxicity during ecotoxicological bioassays is important for credible environmental risk assessments and management in aquatic environments. Actual measurements and reporting of contaminant concentrations in bioassays are, however, often disregarded; and potential contaminant loss attributable to adsorption processes (e.g., wall adsorption) in bioassays is widely omitted, which can have detrimental effects on calculated metal toxicity thresholds. In the present we assessed copper (Cu) mass balance during a standard 48-h bioassay test with blue mussel (Mytilus galloprovincialis) embryos to evaluate effects on calculated toxicity endpoints. We demonstrated that measured Cu concentrations at the test conclusion need to be used to quantify the risk of Cu toxicity because nominal Cu and initial Cu concentrations underestimate overall Cu toxicity by up to 1.5-fold, owing to Cu loss in solution attributable to adsorption and bioaccumulation processes. For the first time we provide evidence that extracellular adsorption to the biological surface of the embryos is the most important sink for total dissolved Cu in a bioassay. We also established that adsorbed extracellular Cu accumulation reduces Cu toxicity to embryos, potentially by inhibiting Cu from entering the cell of the mussel embryo. Environmental factors (e.g., salinity and dissolved organic carbon) did not influence the partitioning of Cu within the laboratory-based bioassay. The present results 1) demonstrate the importance of differentiating extra- and intracellular Cu pools to improve our understanding of Cu toxicity and associated processes, 2) reveal the potential for bias with respect to calculated Cu toxicity thresholds when results are based on nominal and initial Cu concentrations, and 3) point out the need to follow current guidelines for the testing of chemicals to standardize toxicity tests and data reporting. Environ Toxicol Chem 2019;38:561–574. © 2019 SETAC
Abstract
Copper mass-balance of a closed 48-h bioassay with Mytilus galloprovincialis embryos.
Vergleich unterschiedlicher Materialmodelle an einer Aushubsimulation
Authors: Bode Manuel , Schranz Fabian , Medicus Getraud , Fellin Wolfgang 
Published: January 2019

AbstractDie Wahl eines passenden Materialmodells, das in der Lage ist, das Bodenverhalten bei FE‐Berechnungen realistisch darzustellen, hat einen maßgeblichen Einfluss auf die dabei erhaltenen Berechnungsergebnisse. Anhand von Vergleichsrechnungen mit mehreren Materialmodellen sollen die Gemeinsamkeiten und Unterschiede bei den Ergebnissen verdeutlicht werden. Hierfür wird ein Baugrubenaushub simuliert und sowohl die auftretenden Verformungen als auch die mittels Parameterreduktion ermittelte Standsicherheit betrachtet. Dabei wird neben den bekannteren Modellen Hardening Soil und der Hypoplastizität die Barodesie als Modell für FE‐Berechnungen vorgestellt. Während sich bei allen Modellen vergleichbare Verformungen einstellen, werden bei der berechneten Standsicherheit deutliche Unterschiede festgestellt.
Petrogenesis and geochemical characteristics of Early Carboniferous sanukitic high‐Mg andesite from Atengtao Mountain, Yili Block: Implications for the tectonic setting during Late Palaeozoic in Chinese West Tianshan
Authors: Wang Zuopeng , Li Yongjun , Yang Gaoxue , Tong Lili , Li Hai , Luo Yaoqing 
Published: January 2019

As an important part of the Central Asian Orogenic Belt (CAOB), Chinese western Tianshan contains voluminous Late Palaeozoic volcanic rocks. Here, we present geochronological, geochemical, and in situ Lu–Hf isotopic data from the Atengtao sanukitic high‐Mg andesites (HMAs) of the western Yili Block. LA‐ICP‐MS zircon U–Pb analyses indicate that the Atengtao high‐Mg andesites were generated in the Early Carboniferous (346 ± 2 Ma). All the studied rock samples are characterized by high MgO (3.30–5.45 wt.%), SiO2 (53.25–60.10 wt.%), Cr (90.3–157 ppm), and Ni (31.0–46.7 ppm) contents, with geochemical characteristics analogous to those of sanukitoids of the Setouchi Volcanic Belt (SVB), SW Japan, and Bieluagaxi area, West Junggar. The Atengtao sanukitic HMAs are enriched in LILE and LREE but depleted in HFSE, similar to those of typical arc‐related magmatic rocks. They are also characterized by high Nb (11.4–15.8 ppm) concentrations, high Th/La (0.3) and Th/Yb (2.6–4.0) ratios, and varying zircon εHf(t) values (−2.3 to +4.3). These features are suggested to result from the partial melting of a relatively enriched mantle wedge metasomatized by subducting oceanic slab‐derived sediments. Considering the occurrence of sanukitic HMAs, combined with the contemporaneous special rock assemblages (such as slab‐derived adakite, Nb‐enrich basalt, A‐type granite/rhyolite, and bimodal volcanic rocks) found in the western part of Yili Block, we propose that the generation of the Carboniferous sanukitic HMAs in Atengtao Mountain were most likely related to the slab break‐off following the southern Tianshan Ocean slab northward subduction beneath the Yili–Central Tianshan Block. This mechanism not only produces intense magmatism with compositional diversity but also gives rise to a local extension in the western part of Yili Block. The slab break‐off model may play an important role in the crustal growth of the CAOB in Phanerozoic time.
Ocean island basalts and sedimentary units in the accretionary complex of Kochi, SW Japan: Implications for convergent margin tectonics and arc subduction
Authors: Gao Pin , Santosh M. , Nakagawa M. , Li Shan‐Shan 
Published: January 2019

Ocean island basalts (OIBs) and associated sedimentary units form part of the ocean plate stratigraphy accreted onto island arcs or continental arcs and provide important insights into convergent margin processes. Here, we investigate some of the typical localities of Sanpozan, Shirakidani, and Kamiananai within the Chichibu composite belt in Kochi, SW Japan, where the accretionary complexes incorporate OIBs and sedimentary rocks that preserve the travelogue of an oceanic plate from a mid‐oceanic ridge (MOR) to subduction zone. We present petrology and geochemistry, as well as zircon U–Pb geochronology and REE data of the accreted OIB and sedimentary formations from Sanpozan, Shirakidani, and Kamiananai. The OIBs are enriched in LILE and LREE and depleted in HREE. The chondrite‐normalised REE patterns of zircon grains from OIBs and sedimentary rocks display LREE depletion and HREE enrichment, sharply positive Ce and Sm anomalies and negative Pr and Eu. LA‐ICP‐MS U–Pb geochronology of zircon grains from the OIBs shows three major populations with 206Pb/238U mean ages of 164–456, 724–955, and 1,638–2,202 Ma. The diverse ages suggest heterogeneous recycled source components in the plume‐related upwellings that generated the OIBs, as well as different times of formation and accretion of the Palaeozoic and Mesozoic oceanic islands. The dominant population of zircon grains from the sedimentary units shows 206Pb/238U mean ages of 147 and 288 Ma and indicate a major change in the provenance regime with subduction and the disappearance of older arcs attesting to the destruction of continental crust in convergent margins.
Evidence for underuse and overuse of antidepressants in older adults: Results of a large population‐based study
Authors: Boehlen Friederike H. , Freigofas Julia , Herzog Wolfgang , Meid Andreas D. , Saum Kai‐Uwe , Schoettker Ben , Brenner Hermann , Haefeli Walter E. , Wild Beate 
Published: January 2019

ObjectivesDepression is common among elderly people. However, diagnosis and adequate treatment is frequently difficult. Research on underuse and overuse of antidepressants in elderly persons is scarce. This study investigates the utilization and appropriateness of pharmacological and psychological depression treatment in a large cohort of community‐dwelling adults.MethodsA subsample of 3117 participants (aged 55‐85 y) of the third follow‐up (2008‐2010) of the large population‐based German ESTHER study was included. Depression was assessed using the eight‐item Patient Health Questionnaire (PHQ‐8). In the course of a home visit, study doctors collected complete information on medication. Logistic regression analyses were conducted to determine the relationship of depression with both underuse and overuse of antidepressants. The analyses were then adjusted for socioeconomic variables, psychosomatic comorbidities, and motivation to seek help.ResultsOne hundred sixty‐three participants (5.2%; 95% confidence interval [CI], 4.5‐6.1) fulfilled the criteria for major depression. Underuse of antidepressants was present in 126 depressed participants (77.3%; 70.1‐83.5). Persons who were motivated to seek help, who had an established depression diagnosis, or who were taking more than five different medications had lower odds of underuse. Anxiety was associated with higher odds for underuse. Overuse of antidepressants (prescription without clinical indication) was found in 96 cases (41.7%; 35.3‐48.4) of all antidepressant prescriptions.ConclusionsDepression treatment in older adults is frequently insufficient; it appears to depend on diagnosis as well as the patients' motivation to seek help. Education regarding the diagnosis of depression in the elderly as well as guidelines for appropriate treatment is needed.