bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Lower Serum Sclerostin Levels With Elevated Risk for Increased Arterial Stiffness: The JPOS Cohort Study
Authors: Tamaki Junko , Tachiki Takahiro , Jaalkhorol Myadagmaa , Dongmei Namiraa , Komastu Misa , Tsuda Kouji , Kudo Asako , Kamiya Kuniyasu , Kouda Katsuyasu , Kajita Etsuko , Kagamimori Sadanobu , Iki Masayuki 
Published: November 2024

Abstract

Context
Studies on the relationship between serum sclerostin, a Wnt/β-catenin pathway inhibitor, and atherosclerosis have yielded inconsistent results.

Objective
We aim to longitudinally investigate the relationship between serum sclerostin levels and the risk of increased arterial stiffness in Japanese community-dwelling women from the Japanese Population-based Osteoporosis Study (JPOS).

Methods
Of 1044 women aged ≥ 50 years whose brachial-ankle pulse wave velocity (baPWV) value was available in a baseline survey in 2011-2012, we excluded 374 whose baPWV values were ≥ 1800 cm/s, set as the cutoff for increased arterial stiffness, and 8 with missing data. Of the remaining 662 women, 556 participated in the 4- to 5-year follow-up study and were included in the analysis. The coefficient of variation of the sclerostin measurement was 3.45%. We obtained odds ratios (ORs) for sclerostin at baseline, categorized by tertiles, with the high tertile as reference for increased arterial stiffness.

Results
Increased arterial stiffness occurred in 94 women during a mean follow-up of 4.0 years. The increased arterial stiffness rates in the low, medium, and high tertiles were 22.2%, 16.1%, and 12.4%, respectively (trend test P = .013). The ORs for the medium and low tertiles for increased arterial stiffness were 1.58 (P = .205) and 2.16 (P = .027), respectively, after adjusting for age and baseline baPWV. After further adjustment for baseline body mass index, hypertension, hyperlipidemia, diabetes mellitus, estimated glomerular filtration rate, and whole-body bone mineral content, the ORs for the medium and low tertiles were 1.65 (P = .181) and 2.50 (P = .014), respectively.

Conclusion
Lower serum sclerostin levels were associated with elevated risks for increased arterial stiffness in Japanese community-dwelling women.
Extravasation of immune and tumor cells from an endothelial perspective
Authors: Dupas Amandine , Goetz Jacky G. , Osmani Naël 
Published: November 2024

ABSTRACT
Crossing the vascular endothelium is a necessary stage for circulating cells aiming to reach distant organs. Leukocyte passage through the endothelium, known as transmigration, is a multistep process during which immune cells adhere to the vascular wall, migrate and crawl along the endothelium until they reach their exit site. Similarly, circulating tumor cells (CTCs), which originate from the primary tumor or reseed from early metastatic sites, disseminate using the blood circulation and also must cross the endothelial barrier to set new colonies in distant organs. CTCs are thought to mimic arrest and extravasation utilized by leukocytes; however, their extravasation also requires processes that, from an endothelial perspective, are specific to cancer cells. Although leukocyte extravasation relies on maintaining endothelial impermeability, it appears that cancer cells can indoctrinate endothelial cells into promoting their extravasation independently of their normal functions. In this Review, we summarize the common and divergent mechanisms of endothelial responses during extravasation of leukocytes (in inflammation) and CTCs (in metastasis), and highlight how these might be leveraged in the development of anti-metastatic treatments.
How to Staff When Customers Arrive in Batches
Authors: Daw Andrew , Hampshire Robert C. , Pender Jamol J. 
Published: November 2024

In many different settings, requests for service can arrive in near or true simultaneity with one another. This creates batches of arrivals to the underlying queueing system. In this paper, we study the staffing problem for the batch arrival queue. We show that batches place a dangerous and deceptive stress on services, requiring a high amount of resources and exhibiting a fundamentally larger tail in those demands. This uncovers a service regime in which a system with large batch arrivals may have low utilization but will still have nontrivial waiting. Methodologically, these staffing results follow from novel large batch and large batch-and-rate limits of the multiserver queueing model. In the large batch limit, we establish the first formal connection between general multiserver queues and storage processes, another family of stochastic models. By consequence, we show that the batch scaled queue length process is not asymptotically normal and that, in fact, the fluid- and diffusion-type limits coincide. Hence, the (safety) staffing of this system must be directly proportional to the batch size just to achieve a nondegenerate probability of wait. In exhibition of the existence and insights of this large batch regime, we apply our results to data on Covid-19 contact tracing in New York City. In doing so, we identify significant benefits produced by the tracing agency’s decision to staff above national recommendations, and we also demonstrate that there may have been an opportunity to further improve the operation by optimizing the arrival pattern in the public health data pipeline. This paper was accepted by Baris Ata, stochastic models and simulation. Funding: We acknowledge the generous support of the National Science Foundation (NSF) through Andrew Daw’s Graduate Research Fellowship under grant DGE-1650441, received during the initial phase of this research as part of his doctoral studies at Cornell University. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.03979 .
Design and analysis of a far-infrared metamaterial perfect absorber with sensing applications
Authors: Ankit  , Kishor Kamal , Sinha Ravindra Kumar 
Published: November 2024

In this paper, we present an analysis and design of a metamaterial as the perfect absorber and refractive index sensor in the far-infrared (IR) region, utilizing the finite element method (FEM). The structure consists of a metal resonator on a silicon dielectric with a bottom copper layer beneath the dielectric. Our results demonstrate that the designed structure achieves nearly perfect absorption of transverse electric (TE) polarization at a resonance wavelength of λ
r
=9.40µm. This occurs because of the perfect impedance matching condition, which achieves a 99.47% absorption efficiency. This condition is also sensitive to the angle of incidence and causes minimal reflection at the resonating wavelength of λ
r
. This characteristic makes the designed metamaterial structure suitable for use as a sensor. The structure enables maximum electric field confinement in the gap region (g) of the split ring resonator (SRR) at the metal-dielectric interface. The resonance wavelength can be effectively tuned and optimized by varying the gap size (g), dielectric material, dielectric thickness (t
d
), copper layer thickness (t
c
), and incident angle of the metamaterial absorber (MA). The absorption peak shows a highly sensitive response to changes in the refractive index of the surrounding medium, with a sensitivity of 1600 nm/RIU. This absorber, with its excellent absorption in the far-IR spectrum, holds promising potential for applications in energy harvesting and IR sensing.
Photonic properties of InGaN-based micro LEDs in the cryogenic temperature regime
Authors: Chang Hao-Jen , Chiang Ke-Hsi , Jao Yu-Ming , Wang Yuan-Chao , Shih Min-Hsiung , Kuo Hao-Chung , Huang Jian-Jang , Lin Chien-Chung 
Published: November 2024

InGaN/GaN-based micro LEDs ranging from 2 to 100 microns were characterized at cryogenic temperatures to reveal their temperature-dependent photonic properties. An atomic layer deposition technique was applied to passivate the sidewall of the device to enable photon emission of the 2-micron micro LEDs. The size-dependent Shockley-Read-Hall coefficients are extracted via the external quantum efficiency measurements under different temperatures. The micro LEDs’ numerically fitted surface recombination velocity can be as low as 117.85 cm/sec. The emission peak photon energy revealed a non-monotonic variation across the 80 K-300 K temperature range. This behavior closely resembles the S-shaped temperature dependence of the emission peak due to carrier distribution in localized states in InGaN active regions. This localization effect, however, would be reduced when the injected current level increases and the temperature increases beyond 200 K.
MiR-204-5p regulates SIRT1 to promote the endoplasmic reticulum stress-induced apoptosis of inner ear cells in C57BL/6 mice with hearing loss
Authors: Hu Yaqin , Luo Xiaoqin , Chen Hongjiang , Ke Jing , Feng Menglong , Yuan Wei 
Published: November 2024

Purpose
This study investigated the effect of miR-204-5p-mediated silencing of SIRT1 on the development of deafness in C57BL/6 mice and the roles of miR-204-5p and SIRT1 in deafness.

Methods
Auditory brainstem response recordings, H&E staining, and immunohistochemistry were used to observe changes in hearing function and cochlear tissue morphology in 2-month-old and 15-month-old C57BL/6 mice. A senescence model was induced using H2O2 in inner ear cells (HEI-OC1). Changes in HEI-OC1 cell proliferation were detected using the CCK-8 assay, whereas flow cytometry was used to detect changes in apoptosis. MiR-204-5p expression was measured via RT‒qPCR. The SIRT1 agonist RSV and a miR-204-5p inhibitor were used to study changes in ER stress (ERS), proliferation, and apoptosis in HEI-OC1 cells. Western blotting was performed to detect changes in ATF4, CHOP, SIRT1, PERK, p-PERK, Bax, and Bcl-2 protein levels. A dual-luciferase reporter gene assay was carried out to assess the ability of miR-204-5p to target SIRT1.

Results
Relative miR-204-5p expression levels in the cochleae of aged C57BL/6 mice increased, whereas SIRT1 expression levels decreased, and miR-204-5p and SIRT1 expression levels were negatively correlated. ERS and increased 8-OHDG levels were observed in aged C57BL/6 mice. In a model of inner ear cell aging, H2O2 treatment induced increases in miR-204-5p expression and ERS-mediated apoptosis. MiR-204-5p was found to target SIRT1 and inhibit its expression. SIRT1 activation and a miR-204-5p inhibitor promoted HEI-OC1 cell proliferation and reduced apoptosis. The miR-204-5p inhibitor regulated expression of the ERS proteins PERK, ATF4, and CHOP to upregulate Bcl-2 and downregulate Bax.

Conclusion
This study identified the roles of miR-204-5p and SIRT1 in deafness in C57BL/6 mice and investigated the loss of cochlear outer hair cells and the involvement of apoptosis and ERS in deafness.
Nonlinear model predictive controller of hydrogenation of dimethyl oxalate for ethylene glycol production
Authors: Rohman Fakhrony Sholahudin , Wan Alwi Sharifah Rafidah , Muhammad Dinie , Azmi Ashraf , Murat Muhamad Nazri 
Published: November 2024

Abstract
Ethylene glycol (EG) is a valuable commodity organic intermediate that is produced using the catalyzed gas-phase hydrogenation process of dimethyl oxalate (DMO) from syngas. The reactor process is challenging to control because of its nonlinearity and multivariable condition. Thus, this study proposes the application of Neural Wiener model predictive control (NWMPC) for DMO hydrogenation reactor control. The application of empirical-based MPC, such as NWMPC, is still new in DMO hydrogenation reactor control. In order to simulate the process, the DMO hydrogenation reactor is modeled using Aspen Plus and Aspen Dynamic software. The Neural Wiener (NW) model is developed based on state space and neural network modeling using a Linear-Nonlinear (L-N) identification approach. A validation test is also performed to verify the accuracy of the NW model. Based on the test, the model accuracy is acceptable with the coefficient of determination (R2) of 0.965 for EG output mole fraction (first output) and R2 of 0.936 for product temperature (second output). The NWMPC capability is evaluated with a PID controller to handle a setpoint change in EG output mole fraction and reject disturbance in the feed stream flow rate. The control performance results have demonstrated the superior ability of the NWMPC to handle such scenarios better than PID in terms of controller action speed and profile.
Comparative study of deterministic and stochastic optimization algorithms applied to the absorption of CO2 by alkanolamine solution
Authors: Kabouche Azeddine , Kabouche Dounia 
Published: November 2024

Abstract
A model based on simulated annealing approach is used with e-UNIQUAC model as well as two other algorithms to study the absorption of carbon dioxide by monoethanolamine solutions. In this work, we propose to compare the performance (through the knowledge of RMSD values) of two stochastic methods, namely the GA (genetic algorithm) and SA (simulated annealing) methods and a deterministic method that is the simplex method. These methods were applied to the absorption of carbon dioxide by an alkanolamine solution using a chemical equilibrium model and a thermodynamic equilibrium model. The latter is based on the use of the modified-UNIQUAC (UNIQUAC-electrolyte) model instead of e-NRTL model for the liquid phase and a fugacity model for the vapor phase. The chemical equilibrium in this work represents the absorption of CO2 by monoethanolamine solution at different temperatures. Solving the coupled system of material and charge balances gives us the carbon dioxide pressure while taking into account the non-ideality of the system. The three-optimization methods show good agreement with the experimental data with a better performance of the simulated annealing method..
Discoursing Chinese Maritime Law’s structure and reform
Authors: Pucciarelli Clélia , Cheng Le 
Published: November 2024

Abstract
China’s role in the international maritime transport industry is undeniably growing: the country has become the second-largest ship-owning nation, its maritime ports are ranked among the top globally, and its national maritime transport company, COSCO Group, is ranked 4th among major shipping companies. However, its current legal framework is behind the commercial practices of the maritime transport industry and its operators. With both the evolution of China’s position on the global stage and the emergence of new judicial maritime practices, a revision was inevitable, particularly as China aims to build itself into a maritime power. Although the revision of the Maritime Law was included in the 13th National People’s Congress agenda for the period from 2018 to 2023, the revised Law has not yet been promulgated but is expected in near future. While the reform project focuses solely on the Chinese Maritime Law, China’s new ambitions could turn this moment into an opportunity to overhaul and rethink the role of Chinese maritime law in the current global context. Whether by modernizing its maritime law while maintaining its existing structure, or by rethinking its entire approach, China should consider the legal experience of current maritime powers, such as France, which could serve as a valuable source of inspiration for Chinese legislature in the future.
Interactional competence and performances of compliments and consolations by learners of Japanese
Authors: Moody Stephen J. , Peterson Jeff , Tsuchiya Shinsuke , Elzinga Kaitlynne 
Published: November 2024

Abstract
In recent years there has been an increased recognition of the need for learners to understand language as social action. However, language learners are often left on their own to develop the ability to adapt to the unanticipated demands of real-world interaction. To encourage this development, attention is turning toward the notion of interactional competence (IC). The present study contributes to efforts to better understand Japanese learners’ IC. Specifically, this study aims to better understand how learners naturally accomplish compliment and consolation speech acts and for what social purposes, including how learners adapt linguistic forms to do acts that go beyond the act most commonly associated with those forms. Conversation analysis of foreign language housing mealtime conversations revealed two core observations. First, based on preempirical descriptions, compliments occur with more frequency than consolations. Compliments also tend to be deployed as the first part of a compliment-response pair, while consolations tend to be deployed as a response to the public exposure of a challenge or a troubling emotional state. Second, when looking instead at how participants use turns that are construed as compliments regardless of linguistic form, we find that compliments are also used to do activities other than what their surface formulation suggests. A discussion of what these results mean for developing deeper understandings of IC in speech acts performed by language learners is provided.
Immediate effect of sunlight exposure through blue glass on blood pressure in hypertensive patients: a randomized controlled trial
Authors: Yoganathan Deepa , Kuppusamy Maheshkumar , Christa Edmin , Murugan Saran , Elangovan Vijayabharathi , Jayakumar Preetha , Rammohan Sangamithraa 
Published: November 2024

Abstract

Objective
Hypertension affects approximately 1.28 billion adults worldwide, driving the search for integrative therapeutic approaches alongside conventional treatments. While chromotherapy, particularly blue light exposure, has historical roots in traditional medicine and its specific impact on blood pressure regulation remains understudied. So, the present study aims to investigate the immediate impact of exposure to blue glass through sunlight on blood pressure in hypertensive individuals.

Methods
This randomized controlled trial was carried out with a sample of 60 hypertensive patients, who were divided into two groups: a study group that received blue glass exposure for 20 min and a control group that received exposure to colourless glass. The primary outcome measures were systolic and diastolic blood pressure, pulse rate, and oxygen saturation levels.

Results
The results of the study revealed statistically significant differences in systolic blood pressure (p=0.006) and pulse rate (p=0.005) after the intervention in the study group and no such changes were noted in the control group.

Conclusions
The findings of this study suggest that blue glass exposure has a significant impact on reducing blood pressure and pulse rate in hypertensive patients, indicating its potential use as a integrative treatment in the management of hypertension.
An Inquiry into Gender and Queer Issues in Chinese-Language Sci-Fi Film: A Case Study of The Soul
Authors: Cai Jingjing 
Published: November 2024

Abstract
This paper explores the complex portrayal of gender and identity in Cheng Wai-ho’s 2021 science fiction mystery, The Soul. Set in a near-future grappling with RNA-based memory transfer and gender reassignment, the film intertwines technological advancements with social issues like tongqi, marriage trafficking, and transgender representation. Utilizing theories by Prosser, Stryker, and Salamon, the analysis examines how the film depicts transgender characters Wang Shicong and Prosecutor Liang, focusing on their experiences within a system of power dynamics and the exploitation of vulnerable groups. By contrasting the mainland and uncut Netflix versions, the paper delves into the boundaries of Chinese censorship regarding LGBTQ+ themes. This study argues that while The Soul challenges heteronormativity and reveals the complexities of intersectional identities, it also offers opportunities for further critique of its limitations in representation. The film’s contribution to Chinese cinema lies in advancing conversations on gender and sexuality while highlighting the need for social reform.
“The 21st century professionalization?”: online education as an instrument for bolstering individual welfare and societal equality
Authors: Huet Pedro 
Published: November 2024

Abstract
Since the start of the last decade of the 20th century, the application of digital technologies with the potential of making substantial contributions to a community’s welfare have led to the creation of the literature of Public Interest Technologies and reinvigorated many areas of focus in the social sciences. A relevant subfield of this literature has been the application of new technologies to education to increase social public benefits. The traditional literature on higher education seems to agree that the expansion of this good throughout a society is desirable because it generates direct and indirect individual gains, as well as aggregate level social benefits in the form of positive externalities. However, some authors have argued that the acquisition of postsecondary education has its own drawbacks: unwanted intellectual influence of instructors on students, barriers to access for students of historically vulnerable sociodemographic groups, as well as students’ perception of a reduced pay-off from going to college. While there have been some indices that online higher education could abate many of these issues, there has been relatively little formal research to test this tool’s impact. Using a quantitative approach, via cross-section and time-series data analysis, the text finds some evidence that online higher education could solve many of higher education’s drawbacks, while also being a feasible approach given the current technological environment of the United States. The text concludes outlining future research using a mixed-methods approach that could be highly valuable to acquire a more comprehensive view and robust evidence of online higher education’s potential of expanding social public benefits.
Produktives Täuschen. Dissimulatio artis zwischen Rhetorik und Philosophie
Authors: Hetzel Andreas , Pöschel Laura 
Published: November 2024

Abstract
In our paper, we discuss the role of deception (apáte) in the conflict between rhetoric and philosophy. While Parmenides and Plato seek to escape the possibility of being deceived in general, their counterparts, the sophists and early theorists of rhetoric, emphasize that this is neither possible nor desirable. In contrast to their philosophical contemporaries, they do not assume a dualism of truth and deception, but rather a gradualist spectrum that contains many shades of gray. Furthermore, they emphasize a certain productivity of particular deceptions that can help us increase our imagination and prefigure possibilities of life and praxis that would not be possible without being deceived. Moreover, we ask whether and how the potential of classical rhetoric for theorizing deception can be used for a critique of deception that is aware of its own proneness to illusions. The guiding hypothesis is that rhetoric, as a technique of verbal deception, can also provide an important key for criticizing deceptive strategies. This applies in particular to the concept of dissimulatio artis, which goes back to Aristotle’s Rhetoric and had been developed further by Quintilian, Ovid, and the anonymous author of the treatise Perí hýpsous. This concept makes it possible to describe simulations of unsimulatedness in philosophy as well as in politics.
Simulatio/dissimulatio – Stellung/Verstellung: Rhetorik, höfische Verhaltenslehre, Ethik (mit Überlegungen zur Rezeption von Balthasar Graciáns Handorakel in Deutschland)
Authors: Till Dietmar 
Published: November 2024

Abstract
Early modern manuals of courtly conduct offer advice on successful behavior and communication for courtiers, emphasizing masquerade and the concealment of intentions through dissimulatio and simulatio as rhetorical key techniques of the courtier. Important works include Castiglione’s Libro del Cortegiano, Machiavelli’s Principe, and Gracián’s Oráculo manual. Their reception in the German early Enlightenment, especially by Thomasius and Müller, demonstrates the development and recontextualization of these ideas within practical philosophy.