bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric properties of the Children’s Dermatology Life Quality Index in pediatric localized scleroderma
Authors: Ardalan Kaveh , Switzer Galen E , Zigler Christina K , Hershey Nicole M , Torok Kathryn S 
Published: March 2018

Introduction: The Children’s Dermatology Life Quality Index has been used to measure quality of life in studies of pediatric localized scleroderma, which suggested only modest effects on quality of life. However, the Children’s Dermatology Life Quality Index psychometric performance has not been examined in localized scleroderma and it was validated in populations lacking localized scleroderma’s distinctive clinical features, possibly underestimating the quality of life impact. This study assessed psychometric properties of the Children’s Dermatology Life Quality Index in a cohort of pediatric localized scleroderma patients. Methods: Existing Children’s Dermatology Life Quality Index data from a large pediatric localized scleroderma cohort were analyzed. Children’s Dermatology Life Quality Index score distributions were examined and internal consistency was evaluated with Cronbach’s alpha for the entire Children’s Dermatology Life Quality Index and after deletion of individual items. Construct validity was assessed by calculating Spearman’s correlations between Children’s Dermatology Life Quality Index scores and disease severity/impact measures. Dimensionality was examined using exploratory factor analysis with sequential item elimination. Results: Children’s Dermatology Life Quality Index scores suggested modest adverse effects on quality of life. Internal consistency was adequate (Cronbach’s alpha = 0.727) but increased after eliminating items regarding friendships, sleep, and treatment burdens. Children’s Dermatology Life Quality Index scores were not associated with physician-scored disease severity measures but were moderately associated with patient/parent assessments of disease impact. Exploratory factor analysis yielded a three-factor solution encompassing functional limitations, psychosocial effects, and skin symptoms/treatment burden. Conclusion: The Children’s Dermatology Life Quality Index may capture functional and psychosocial domains of quality of life in localized scleroderma, but likely underestimates the quality of life impact given that it includes some items with limited relevance in localized scleroderma, incompletely explores skin symptoms and treatment burdens, and demonstrates limited construct validity. Further study to optimize quality of life measurement in pediatric localized scleroderma is warranted.
Oral Bruton tyrosine kinase inhibitors selectively block atherosclerotic plaque–triggered thrombus formation in humans
Authors: Busygina Kristina , Jamasbi Janina , Seiler Till , Deckmyn Hans , Weber Christian , Brandl Richard , Lorenz Reinhard , Siess Wolfgang 
Published: March 2018

Key Points
Btk inhibitors specifically block platelet thrombus formation on atherosclerotic plaque but spare physiologic hemostasis. Irreversible Btk inactivation in platelets incapable of enzyme resynthesis allows low intermittent drug dosing for antiatherothrombosis.
Qualitative exploration of the effect of a television soap opera storyline on women with experience of postpartum psychosis
Authors: Roberts Lewis , Berrisford Giles , Heron Jessica , Jones Lisa , Jones Ian , Dolman Clare , Lane Deirdre A. 
Published: March 2018

BackgroundPostpartum psychosis has recently been the focus of an in-depth storyline on a British television soap opera watched by millions of viewers.AimsThis research explored how the storyline and concomitant increase in public awareness of postpartum psychosis have been received by women who have recovered from the condition.MethodNine semistructured, one-to-one interviews were conducted with women who had experienced postpartum psychosis. Thematic analysis consistent with Braun and Clarke's six-step approach was used to generate themes from the data.ResultsPublic exposure provided by the postpartum psychosis portrayal was deemed highly valuable, and its mixed reception encompassed potentially therapeutic benefits in addition to harms.ConclusionsPublic awareness of postpartum psychosis strongly affects women who have experienced postpartum psychosis. This research highlights the complexity of using television drama for public education and may enable mental health organisations to better focus future practices of raising postpartum psychosis awareness.Declaration of interestGB is chair of action on Postpartum Psychosis. JH is director of action on Postpartum Psychosis. IJ is a trustee of action on Postpartum Psychosis and was a consultant to the BBC (television company) on the EastEnders storyline. CD is a trustee of action on Postpartum Psychosis, a trustee of BIPOLAR UK, vice chair of the Maternal Mental Health Alliance, and was a consultant to the BBC (television company) on the EastEnders storyline.
Evaluation of a Streamlined Oncologist-Led BRCA Mutation Testing and Counseling Model for Patients With Ovarian Cancer
Authors: Colombo Nicoletta , Huang Gloria , Scambia Giovanni , Chalas Eva , Pignata Sandro , Fiorica James , Van Le Linda , Ghamande Sharad , González-Santiago Santiago , Bover Isabel , Graña Suárez Begoña , Green Andrew , Huot-Marchand Philippe , Bourhis Yann , Karve Sudeep , Blakeley Christopher 
Published: March 2018

Purpose There is a growing demand for BRCA1/ 2 mutation ( BRCAm) testing in patients with ovarian cancer; however, the limited number of genetic counselors presents a potential barrier. To facilitate more widespread BRCAm testing in ovarian cancer, pretest counseling by the oncology team could shorten testing turnaround times and ease the pressure on genetic counselors. Patients and Methods The prospective, observational Evaluating a Streamlined Onco-genetic BRCA Testing and Counseling Model Among Patients With Ovarian Cancer (ENGAGE) study evaluated a streamlined, oncologist-led BRCAm testing pathway. The analysis population comprised 700 patients with ovarian cancer at 26 sites in the United States, Italy, and Spain. The primary objectives were to assess turnaround time and, using questionnaires, to evaluate stakeholder satisfaction (patients, oncologists, and geneticists or genetic counselors) with the oncologist-led BRCAm testing pathway. Results The median overall turnaround time was 9.1 weeks (range, 0.9 to 37.1 weeks), with median turnaround times in the United States, Italy, and Spain of 4.1 weeks (range, 0.9 to 37.1 weeks), 20.4 weeks (range, 2.9 to 35.4 weeks), and 12.0 weeks (range, 2.0 to 36.7 weeks), respectively. Patient satisfaction with the oncologist-led BRCAm testing pathway was high, with > 99% of patients expressing satisfaction with pre- and post- BRCAm test counseling. Oncologist satisfaction with the BRCAm testing pathway was also high, with > 80% agreeing that the process for performing BRCAm testing worked well and that counseling patients on BRCAm testing was an efficient use of their time. Oncologists expressed higher levels of satisfaction with the BRCAm testing pathway than did geneticists or genetic counselors. Conclusion The results of the ENGAGE study demonstrate that an oncologist-led BRCAm testing process is feasible in ovarian cancer. Development of local BRCAm testing guidelines similar to the one used in this study could allow faster treatment decisions and better use of resources in the management of patients with ovarian cancer.
Concurrent Veliparib With Chest Wall and Nodal Radiotherapy in Patients With Inflammatory or Locoregionally Recurrent Breast Cancer: The TBCRC 024 Phase I Multicenter Study
Authors: Jagsi Reshma , Griffith Kent A. , Bellon Jennifer R. , Woodward Wendy A. , Horton Janet K. , Ho Alice , Feng Felix Y. , Speers Corey , Overmoyer Beth , Sabel Michael , Schott Anne F. , Pierce Lori ,   for the Translational Breast Cancer Research Consortium
Published: March 2018

Purpose Locoregional control for inflammatory breast cancers and chest wall recurrences is suboptimal, which has motivated interest in radiosensitization to intensify therapy. Preclinical studies have suggested a favorable therapeutic index when poly (ADP-ribose) polymerase inhibitors are used as radiosensitizers; clinical investigation is necessary to establish appropriate dosing and confirm safety. Patients and Methods We conducted a multi-institutional phase I study of veliparib and concurrent radiotherapy (RT) to the chest wall and regional lymph nodes in 30 patients with inflammatory or locally recurrent breast cancer after complete surgical resection. RT consisted of 50 Gy to the chest wall and regional lymph nodes plus a 10-Gy boost. A Bayesian time-to-event continual reassessment method escalated dose through four levels, with a 30% targeted rate of dose-limiting toxicity (DLT) measured during the 6 weeks of treatment plus 4 weeks of follow-up. DLTs were defined as confluent moist desquamation > 100 cm2, nonhematologic toxicity grade ≥ 3, toxicity that requires an RT dose delay > 1 week, absolute neutrophil count < 1,000/mm3, platelet count < 50,000/mm3, or hemoglobin < 8.0 g/dL if possibly, probably, or definitely related to study treatment. Results Five DLTs occurred: Four were moist desquamation (two each at 100 and 150 mg twice a day), and one was neutropenia (at 200 mg twice a day). The crude rate of any grade 3 toxicity (regardless of attribution) was 10% at year 1, 16.7% at year 2, and 46.7% at year 3. At year 3, six of 15 surviving patients had severe fibrosis in the treatment field. Conclusion Although severe acute toxicity did not exceed 30% even at the highest tested dose, nearly half of surviving patients demonstrated grade 3 adverse events at 3 years, which underscores the importance of long-term monitoring of toxicity in trials of radiosensitizing agents.
Hsp70–Hsp110 chaperones deliver ubiquitin-dependent and -independent substrates to the 26S proteasome for proteolysis in yeast
Authors: Kandasamy Ganapathi , Andréasson Claes 
Published: March 2018

ABSTRACT
During protein quality control, proteotoxic misfolded proteins are recognized by molecular chaperones, ubiquitylated by dedicated quality control ligases and delivered to the 26S proteasome for degradation. Proteins belonging to the Hsp70 chaperone and Hsp110 (the Hsp70 nucleotide exchange factor) families function in the degradation of misfolded proteins by the ubiquitin-proteasome system via poorly understood mechanisms. Here, we report that the Saccharomyces cerevisiae Hsp110 proteins (Sse1 and Sse2) function in the degradation of Hsp70-associated ubiquitin conjugates at the post-ubiquitylation step and are also required for ubiquitin-independent proteasomal degradation. Hsp110 associates with the 19S regulatory particle of the 26S proteasome and interacts with Hsp70 to facilitate the delivery of Hsp70 substrates for proteasomal degradation. By using a highly defined ubiquitin-independent proteasome substrate, we show that the mere introduction of a single Hsp70-binding site renders its degradation dependent on Hsp110. The findings define a dedicated and chaperone-dependent pathway for the efficient shuttling of cellular proteins to the proteasome with profound implications for understanding protein quality control and cellular stress management.
NearSense – Advances Towards a Silicon-Based Terahertz Near-Field Imaging Sensor for Ex Vivo Breast Tumour Identification
Authors: Mavarani Laven , Hillger Philipp , Bücher Thomas , Grzyb Janusz , Pfeiffer Ullrich R. , Cassar Quentin , Al-Ibadi Amel , Zimmer Thomas , Guillet Jean-Paul , Mounaix Patrick , MacGrogan Gaëtan 
Published: March 2018

AbstractBreast Cancer is one of the most frequently diagnosed cancer diseases worldwide, and the most common invasive tumour for women. As with all cancers, early detection plays a major role in reducing the mortality and morbidity rate. Currently, most breast cancers are detected due to clinical symptoms, or by screening mammography. The limitations of these techniques have resulted in research of alternative methods for imaging and detecting breast cancer. Apart from this, it is essential to define precise tumour margins during breast-conserving surgeries to reduce the re-excision rate. This study presents the advances in the development of a silicon-based THz sub-wavelength imager usable in life science applications, especially for tumour margin identification.
A Robust Algorithm for Nonlinear Variable-Order Fractional Control Systems with Delay
Authors: António Tenreiro Machado José , Parsa Moghaddam Behrouz 
Published: March 2018

Abstract
In this paper, we propose a high-accuracy linear B-spline finite-difference approximation for variable-order (VO) derivative. We consider VO fractional differentiation as a control parameter for improving the stability in systems exhibiting vibrations. The method is applied to nonlinear feedback with VO fractional derivative. The results demonstrate the efficiency and high accuracy of the novel algorithm.
Filmästhetik als Potential medienkultureller Bildung
Authors: Lay Tristan 
Published: March 2018

ZusammenfassungDer systematischen Implementierung filmspezifischer Arbeit im Fremdsprachenunterricht kommt in der Unterrichtsrealität immer noch eine marginale Rolle zu. Auch wenn seit etwa zehn Jahren ein Anstieg der Forschungsarbeiten zu diesem Themenbereich in den Disziplinen, die sich mit dem Lehren und Lernen fremder Sprachen auseinandersetzen, zu konstatieren ist, besteht indes in Fachveröffentlichungen der letzten Jahre Konsens darüber, dass der gezielte Filmeinsatz im landeskundlichen Sprachunterricht eher sporadisch ausfällt. Vor dem Hintergrund einer sich bereits vollzogenen visuellen Zeitenwende, die auch und insbesondere die Lebenswelt und Perzeptionsgewohnheiten unserer Lerner tiefgreifend verändert hat, ist die marginale Bedeutung und der aktuelle Stellenwert des Mediums Film in institutionalisierten Bildungskontexten kritisch zu hinterfragen. Eine stärkere Auseinandersetzung mit fremdsprachigen Filmen in der Sprach- und Kulturvermittlung kann beispielsweise durch die Erarbeitung und Bereitstellung von leicht adaptierbaren und modifizierbaren Didaktisierungsvorgaben gefördert werden. Dieser Beitrag möchte anhand des SpielfilmsLoreMöglichkeiten der Filmästhetik zur sprachlich-kulturellen Bildung von Deutschlernern aufzeigen, indem auf die Arbeit mit filmischen Gestaltungsmitteln für den Unterricht eingegangen wird, deren ästhetische Einbindung Voraussetzung einer erfolgreichen Kommunikation zwischen Film und Rezipient darstellt.
Filmwissenschaft als „Kulturwissenschaft aus der Ferne“
Authors: Viering Julia 
Published: March 2018

ZusammenfassungDie Darstellung ausgewählter Ergebnisse einer Analyse öffentlich zugänglicher, vermeintlich wertungsfreier Informationsmaterialien soll veranschaulichen, wie die Auswahl spezifischer Darstellungsformen dazu beitragen kann, gesellschaftliche Ungleichheit zu reproduzieren. Angelehnt an die Diskursanalyse nach Viehöver, der Diskurse als Narrationen fasst, plädiert dieser Beitrag dafür, die Analyse filmischen Erzählens als Gegenstand empirischer Studien im DaF/DaZ-Kontext zu etablieren und forschungsmethod(olog)isch reflektiert einzusetzen. Ausgangspunkt war die Hypothese, dass innerhalb der einzelnen Berufsinformationsfilme nicht nur die berufliche, sondern auch die soziale/gesellschaftliche Integration junger Erwachsener narrativisiert wird und somit gesellschaftliche Integrationserwartungen sichtbar werden.
Informationswissenschaft in der Urbanistik
Authors: Stock Wolfgang G. , Barth Julia , Fietkiewicz Kaja J. , Gremm Julia , Hartmann Sarah , Henkel Maria , Ilhan Aylin , Mainka Agnes , Meschede Christine , Peters Isabella 
Published: March 2018

Zusammenfassung
Zeitgenössische und zukünftige Städte der Wissensgesellschaft werden oft als „smarte Städte“, „digitale Städte“ oder „ubiquitäre Städte“, „Wissensstädte“ und „kreative Städte“ bezeichnet. Die informationelle Urbanistik umfasst alle Aspekte von Information und (implizitem wie explizitem) Wissen in Hinblick auf städtische Regionen. „Informationelle Stadt“ (oder „smarte Stadt“ im weiteren Sinne) ist ein Sammelbegriff, der die unterschiedlichen Trends der informationsbezogenen Stadtforschung vereint. Die informationelle Stadtforschung ist ein interdisziplinäres Unternehmen, das einerseits Informatik und Informationswissenschaft sowie andererseits Stadtforschung, Stadtplanung, Architektur, Stadtökonomie und Stadtsoziologie vereint. In diesem Artikel präsentieren wir Ergebnisse unserer empirischen Studien über solche Städte auf der ganzen Welt. Der fundierende theoretische Rahmen besteht aus sieben Bausteinen, nämlich Informations- und Wissensinfrastrukturen, Wirtschaft, Politik (E-Governance) und Verwaltung (E-Government), Räume (Raum der Ströme und Raum der Orte), Standortfaktoren, das Informationsverhalten der Menschen und die Problembereiche.
Thermoluminescence properties of undoped diamond films deposited using HF CVD technique
Authors: Paprocki K. , Winiecki J. , Kabacińska R. , Przegietka K. , Szybowicz M. , Fabisiak K. 
Published: March 2018

Abstract
Natural diamond has been considered as a perspective material for clinical radiation dosimetry due to its tissuebiocompatibility and chemical inertness. However, the use of natural diamond in radiation dosimetry has been halted by the high market price. The recent progress in the development of CVD techniques for diamond synthesis, offering the capability of growing high quality diamond layers, has renewed the interest in using this material in radiation dosimeters having small geometricalsizes. Polycrystalline CVD diamond films have been proposed as detectors and dosimeters of β and α radiation with prospective applications in high-energy photon dosimetry. In this work, we present a study on the TL properties of undoped diamond film samples grown by the hot filament CVD (HF CVD) method and exposed to β and α radiation. The glow curves for both types of radiation show similar character and can be decomposed into three components. The dominant TL peaks are centered at around 610 K and exhibit activation energy of the order of 0.90 eV.
Crystal structure of 7-(4-methylphenyl)imidazo[1,2-a][1,3,5]triazin-4-amine, C12H11N5
Authors: Lim Felicia Phei Lin , Dolzhenko Anton V. , Halcovitch Nathan R. , Tiekink Edward R.T. 
Published: March 2018

Abstract
C12H11N5, monoclinic, P21/n (no. 14), a = 7.3455(1) Å, b = 12.2470(1) Å, c = 12.1689(1) Å, β = 103.505(1)°, V = 1064.45(2) Å3, Z = 4, R
gt(F) = 0.0365, wR
ref(F
2) = 0.0987, T = 100 K.
Success Criteria for Different Forms of Dialogue
Authors: Hösle Vittorio 
Published: March 2018

SummaryThe article proposes a typology of the forms of dialogue, which is influenced by Schleiermacher's triadic subdivision and distinguishes dialogues oriented toward agreement of wills, dialogues experienced as ends in themselves, and dialogues oriented toward agreement on truth. Each of these three types has different success criteria; particularly I show why Grice's maxims of conversation are not valid for all dialogues: In conversations, for example, irony is legitimate and enriching. The general reflections are then applied to the specific case of the intercultural dialogue.
“With God all things are possible” – Luther and Kierkegaard on the relation between immutability, necessity and possibility
Authors: Alfsvåg Knut 
Published: March 2018

SummaryIf God is eternal, he is immutable and his relationship with the world is without change. Luther and Kierkegaard agree that this is the case, but disagree whether the idea of necessity adequately captures God’s relationship with the world. Luther inherits the idea of necessity from the Scholastics, but rejects their distinction between absolute and conditional necessity. We can only trust God’s promises if there from God’s point of view are no contingencies. For Kierkegaard, the idea of necessity is determined by Kant’s understanding of reality as experience limited by what is possible according to the criteria of rationality. Kierkegaard finds this understanding insufficient, as it excludes the possibility of the infinite. In spite of differences of terminology caused by the differing contexts they had to address, there is thus a significant parallel between Luther and Kierkegaard in that they both criticize their contemporaries for having a deficient understanding of divine difference.
Apophatic Panentheism: Catherine Keller’s Constructive Theology
Authors: Benjamins Rick 
Published: March 2018

SummaryCatherine Keller’s constructive theology includes an original and very interesting combination of process theology, feminist theology and negative theology. This combination culminates in the articulation of an “apophatic panentheism” that is urgent for its accentuation of connectivity and interdependency in our global world. In this article, Keller’s apophatic panentheism is clarified on the basis of her major works on the relational self, creation, apocalyptic patterns of thought, and negative theology.
‘Figures in 3D’: Digital Perspectives on Cretan Bronze Age Figurines
Authors: Morris Christine , Peatfield Alan , O’Neill Brendan 
Published: March 2018

Abstract
The largest corpus of clay figurines from the Cretan Bronze Age comes from ritual mountain sites known as peak sanctuaries. In this paper, we explore how the ‛Figures in 3D’ project contributes to our understanding of these figurines, aiding in the study of the technologies of figurine construction and the typological analysis of distinctive styles. We discuss how the project has, more unexpectedly, begun to create new dialogues and opportunities for moving between the material and the digital by taking a multifaceted approach that combines the data from 3D models and 3D prints with experimental work in clay.
A concise treatment of pterins: some recent synthetic and methodology aspects and their applications in molecular sensors
Authors: Goswami Shyamaprosad , Das Manas Kumar , Sain Dibyendu , Goswami Bhaswati 
Published: March 2018

AbstractA concise account of pterins in chemistry and biology and their applications in molecular sensors including their optical spectroscopic properties are described. Different natural, synthetic, biological and photophysical aspects are also discussed. Synthetic access to direct functionalised pterins and a recently reported new thiophene annulation technique are described for the synthesis of Form B of molybdenum cofactor. The receptor properties of fluorescent pterin molecules including selenopyrimidines which are rarely reported for their binding of anions and neutral molecules are also of major importance in this review. For such an old and still so young, unexplored pterin system on its power to be sensitive for physical studies especially the interaction with cations, anions and neutral molecules are fascinating and research in this area is relatively new and expected to increase fast. Pterin based receptors are for the first time put into a useful review for the advantage of those who want to explore pterin and modified pterin as chromogenic and fluorogenic sensors.