bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local Antibiotic Prophylaxis in Surgery
Authors: Martin Claude , Viviand Xavier , Potié Frédéric 
Published: May 2019

AbstractThe perioperative use of antibiotics is an established and accepted technique for the prevention of postoperative infection. Intravenous administration often is preferred, and intramuscular administration is possible, although it has certain drawbacks. This article examines a variety of other routes of administration for delivering antibiotics locally to the surgical site. These techniques merit further study in prospectively randomized trials.
Selected Aspects of the Socioeconomic Impact of Nosocomial Infections: Morbidity, Mortality, Cost, and Prevention
Authors: Jarvis William R. 
Published: May 2019

AbstractApproximately 2 million nosocomial infections occur annually in the United States. These infections result in substantial morbidity, mortality, and cost. The excess duration of hospitalization secondary to nosocomial infections has been estimated to be 1 to 4 days for urinary tract infections, 7 to 8.2 days for surgical site infections, 7 to 21 days for bloodstream infections, and 6.8 to 30 days for pneumonia. The estimated mortalities associated with nosocomial bloodstream infections and pneumonia are 23.8% to 50% and 14.8% to 71% (overall), or 16.3% to 35% and 6.8% to 30% (attributable), respectively. The estimated average costs of these infections are $558 to $593 for each urinary tract infection, $2,734 for each surgical site infection, $3,061 to $40,000 for each bloodstream infection, and $4,947 for each pneumonia. Even minimally effective infection control programs are cost-effective. In countries with prospective payment systems based on diagnosis-related groups, hospitals lose from $583 to $4,886 for each nosocomial infection. As administrators focus on cost containment, increased support should be given to infection control programs so that preventable nosocomial infections and their associated expenditures can be averted.
Comparison of a Rapid Readout Biological Indicator for Steam Sterilization With Four Conventional Biological Indicators and Five Chemical Indicators
Authors: Rutala William A. , Jones Suzanne M. , Weber David J. 
Published: May 2019

AbstractObjective:In this study, we compare a new biological indicator that provides results within 3 hours with four conventional, 48-hour biological indicators and five chemical indicators.Design:Biological indicators tested included the conventional Attest 1262, Proof Plus, Assert, and Biosign, and the new Attest 1292 Rapid Readout biological indicator. Chemical indicators tested included Comply, Propper, Chemdi, Sterigage, and Thermalog S. Spore survival following 121°C in a gravity displacement sterilizer was measured by media color change after incubation for 24 and 48 hours at 56°C for the conventional biological indicators, fluorescence at 3 hours for the Attest 1292 Rapid Readout biological indicator, and color change for the chemical indicators. Each exposure time was replicated 12 times with five samples of each indicator per run (ie, 60 replicates per indicator).Results:At 48 hours, the conventional biological indicators Attest 1262, Proof Plus, Assert, and Biosign showed 100%, 95%, 88%, and 93% spore survival at 5 minutes' exposure; 0%, 0%, 0%, and 8% at 10 minutes; and all showed 0% survival at 15 minutes' exposure. Following a 3hour incubation, the Attest 1292 Rapid Readout biological indicator showed fluorescence at 100%, 72%, and 0% at 5, 10, and 15 minutes, respectively. The chemical indicators Comply, Propper, Chemdi, Sterigage, and Thermalog S revealed sterilization failure rates of 100%, 100%, 100%, 100%, and 100% at 5 minutes' exposure; 0%, 0%, 0%, 92%, and 100% at 10 minutes; and, 0%, 0%, 0%, 3%, and 27% at 15 minutes' exposure, respectively.Conclusions:The sensitivity of the Attest 1292 Rapid Readout biological indicator parallels that of conventional biological indicators. These data suggest that a 3hour rapid readout biological indicator is equivalent to a standard 48-hour biological indicator. Some chemical indicators (eg, Thermalog S) failed to indicate adequate sterilization at 15 minutes' exposure. These chemical indicators have the potential of causing unnecessary recall of adequately sterilized items.
Dissolving the Problem of Infectious Medical Waste
Authors: Crow Sue 
Published: May 2019

AbstractDecisions in purchasing healthcare products are based on fiscal responsibility, employee safety, regulatory agency guidelines, and environmental conservation. One of today's major dilemmas in health care is that of disposing of medical waste. The Isolyser Company of Norcross, Georgia, is one of the first to develop a biocycle system to reduce the problem of contaminated waste. A description of the system is provided, along with its advantages and disadvantages.
Intuitive syllabification: universals and language specific constraints
Authors: Gillis Steven , De Schutter Georges 
Published: May 2019

ABSTRACTIntuitive syllabifications of 50 five- and six- and 50 eight-year-old children are studied in an experimental setting. The children syllabified Dutch disyllabic words with a single intervocalic consonant that were presented orally to them. The aim was to find out if these syllabifications adhered to the universal principles of syllable structure and if the children's syllabifications witnessed an overruling of the universal phonological constraints by language specific ones. Results indicate that universal principles are sufficient to explain syllabifications. Except for obligatory onset formation, other principles act as soft constraints that are influenced by factors such as stress and vowel and consonant quality. A language specific constraint proposed in the phonological literature, namely bimoraic minimality, is hypothesized to be a result of children's familiarization with the spelling conventions.
Linguistic influences on categorization in preschool children: a crosslinguistic study
Authors: Martinez Ivelisse M. , Shatz Marilyn 
Published: May 2019

ABSTRACTResearch on categorization suggests that information conveyed by language may be a guide for children performing classification tasks. In our study we asked whether differences between languages in linguistic form influence this performance. Thirty-five three- and four-year-old monolingual speakers of Spanish and English, languages differing in the way they encode gender, were tested in their native countries on a classification task of familiar objects. This task assessed strategies used in (1) a free sort, (2) a sort with instructions to use natural gender, and (3) one (for the Spanish speakers) with specific instructions to use grammatical gender. Half of both the Spanish and the English groups used animacy as a sorting strategy in the first sort, whereas the majority of both groups sorted by natural gender in the second sort. Most Spanish speakers also used grammatical gender as a categorizing strategy in at least one of the sorts. Results suggest that both instructional context and language-specific experience can influence the ways children classify familiar referents.
Children's understanding of epistemic modals
Authors: Noveck Ira A. , Ho Simon , Sera Maria 
Published: May 2019

ABSTRACTPrior empirical work in semantic development has produced an impressive finding showing that children can reliably detect a modal's relative force (e.g. that must is stronger sounding than may) by five-and-a-half years of age. We investigate the extent to which a representation of relative force can account for an understanding of epistemic modals when their logical meaning is considered (i.e. when modals are interpretable as expressions of necessary and possible conclusions). Experiment 1 presents a replication of Hirst & Weil's hidden-object task, which originally included the supremely forceful indicative is. Thirty-two five-year-olds were required to find a peanut hidden under one of two containers based on a pair of statements that contrasted is with has to, has to with might, or is with might. Half the children were entitled to search for the peanut upon hearing the two statements and half were required to indicate only where they would look. Results largely confirmed the influence of relative force in this paradigm. Both groups of children usually searched under the container associated with the stronger-sounding term. Experiment 2 employed a modified version of the hidden-object task in which contrasts presented one true and one false modal statement and 32 five-year-olds, 20 seven-year-olds, 16 nine-year-olds and 20 adults were asked to determine which of two statements was correct. Half the contrasts presented a relatively weaker-sounding modal term in the true statement and the other half presented equally forceful modal terms in the two statements. No age group systematically endorsed a false stronger-sounding modal statement over a true weaker-sounding one. The five-year-olds' rate of correct responding overall was above levels predicted by chance. Mature logical modal understanding was found among seven-year-olds who routinely endorsed a contrast's true modal statement. These findings suggest that deductive inference is an early semantic component of modal terms.
How children talk about a conversation
Authors: Özyürek Asli 
Published: May 2019

ABSTRACTThis study investigates how children of different ages talk about a conversation that they have witnessed. 48 Turkish children, five, nine and thirteen years in age, saw a televised dialogue between two Sesame Street characters (Bert and Ernie). Afterward, they narrated what they had seen and heard. Their reports were analysed for the development of linguistic devices used to orient their listeners to the relevant properties of a conversational exchange. Each utterance in the child's narrative was analysed as to its conversational role: (1) whether the child used direct or indirect quotation frames; (2) whether the child marked the boundaries of conversational turns using speakers' names and (3) whether the child used a marker for pairing of utterances made by different speakers (agreement-disagreement, request-refusal, questioning-answering). Within pairings, children's use of (a) the temporal and evaluative connectivity markers and (b) the kind of verb of saying were identified. The data indicate that there is a developmental change in children's ability to use appropriate linguistic means to orient their listeners to the different properties of a conversation. The development and use of these linguistic means enable the child to establish different social roles in a narrative interaction. The findings are interpreted in terms of the child's social-communicative development from being a ‘character’ to becoming a ‘narrator’ and ‘author’ of the reported conversation in the narrative situation.
Event structures and non-orthogonal term graph rewriting
Authors: Clark David , Kennaway Richard 
Published: May 2019

We show that for every term graph in a left-linear but non-orthogonal term graph rewrite system, one can construct an event structure that represents all the possible reductions that can occur in reduction sequences starting from that term graph. Every finite reduction sequence from that graph corresponds to a configuration of the event structure, and Lévy-equivalent sequences correspond to the same configuration.Garbage collection is modelled in the event structure by an ‘erases’ relation. The asymmetric conflicts that arise in non-orthogonal rewrite systems are modelled by introducing a ‘prevents’ relation. The configurations of the event structure then form the state space of an event automaton. Taking the directed completion of this space yields a prime algebraic domain.
Subtyping psychological distress in the population: a semi-parametric network approach
Authors: de Vos S. , Patten S. , Wit E. C. , Bos E. H. , Wardenaar K. J. , de Jonge P. 
Published: May 2019

AbstractAimsThe mechanisms underlying both depressive and anxiety disorders remain poorly understood. One of the reasons for this is the lack of a valid, evidence-based system to classify persons into specific subtypes based on their depressive and/or anxiety symptomatology. In order to do this withouta prioriassumptions, non-parametric statistical methods seem the optimal choice. Moreover, to define subtypes according to their symptom profiles and inter-relations between symptoms, network models may be very useful. This study aimed to evaluate the potential usefulness of this approach.MethodsA large community sample from the Canadian general population (N= 254 443) was divided into data-driven clusters using non-parametrick-means clustering. Participants were clustered according to their (co)variation around the grand mean on each item of the Kessler Psychological Distress Scale (K10). Next, to evaluate cluster differences, semi-parametric network models were fitted in each cluster and node centrality indices and network density measures were compared.ResultsA five-cluster model was obtained from the cluster analyses. Network density varied across clusters, and was highest for the cluster of people with the lowest K10 severity ratings. In three cluster networks, depressive symptoms (e.g. feeling depressed, restless, hopeless) had the highest centrality. In the remaining two clusters, symptom networks were characterised by a higher prominence of somatic symptoms (e.g. restlessness, nervousness).ConclusionFinding data-driven subtypes based on psychological distress using non-parametric methods can be a fruitful approach, yielding clusters of persons that differ in illness severity as well as in the structure and strengths of inter-symptom relationships.
The Impact of Turbulence and Convection on Transport in the Southern Ocean
Authors: Sohail Taimoor , Vreugdenhil Catherine A. , Gayen Bishakhdatta , Hogg Andrew McC. 
Published: May 2019

AbstractVolume transport in the presence of fully resolved convection and turbulence is investigated in a reentrant channel model of the Southern Ocean. The response of the meridional overturning and zonal transport to variations in wind and buoyancy forcing is quantified. Our simulations show two overturning cells—a buoyancy‐driven lower cell and a wind‐driven upper cell. The lower overturning cell is much larger in meridional extent and magnitude than the upper cell. The mean component of the overturning transport is smaller than the fluctuating component in the lower overturning cell, indicating that transport is dominated by eddies and/or turbulent convective flow. In contrast, the upper cell can be primarily described as a mean flow (indicating minimal eddy compensation). Both cells strengthen with increasing winds, with the upper cell being more sensitive to increasing wind intensity than the lower cell. Scaling for the mean upper overturning is also derived and matches previous theories which predict a linear sensitivity of the upper cell to wind. Zonal transport remains insensitive to increasing wind stress, suggesting that the system is eddy saturated when turbulence and eddies are resolved. These results suggest that fine‐scale flows control zonal transport and abyssal meridional overturning in the Southern Ocean, while wind stress drives the upper meridional overturning transport, highlighting the importance of accurately characterizing turbulence and convection in large‐scale models.
The efficiency of a new automated mosquito larval counter and its impact on larval survival
Authors: Mamai W. , Maiga H. , Gárdos M. , Bán P. , Bimbilé Somda N. S. , Konczal A. , Wallner T. , Parker A. , Balestrino F. , Yamada H. , Gilles J. R. L. , Bouyer J. 
Published: May 2019

AbstractTo achieve consistent and standardized rearing for mosquito immature stages, it is crucial to control the initial number of larvae present in each larval tray. In addition, maintaining an optimal and synchronized development rate of larvae is essential to maximize the pupal production and optimize male sorting in a mass-rearing setting. Manual counting is labor intensive, time consuming and error prone. Therefore, this study aimed to investigate the use of a customized automated counter for the quantification of mosquito larvae. The present prototype of the mosquito larval counter uses a single counting channel consisting of three parts: a larvae dispenser, an electronic counting unit and computer control software. After the separation of the larvae from eggs and debris, batches of different numbers of Aedes aegypti first instar larvae were manually counted and introduced into the counter through the upper loading funnel and channeled out from the bottom of the counter by gravitational flow. The accuracy and repeatability of the mosquito larval counter were determined in relation to larval density and water quality. We also investigated its impact on larval survival. Results showed an impact of larval density and water quality on the accuracy of the device. A −6% error and a repeatability of +/− 2.56% average value were achieved with larval densities up to 10 larvae/mL of clean water. Moreover, the use of the mosquito larval counter did not have any effect on larval survival or development. Under recommended conditions, the mosquito larval counter can be used to enumerate the number of mosquito larvae at a given density. However, future developments involving the use of multiple channels or larger input larvae container would help to expand its use in large-scale facilities.
Extended 3D-PTV for direct measurements of Lagrangian statistics of canopy turbulence in a wind tunnel
Authors: Shnapp Ron , Shapira Erez , Peri David , Bohbot-Raviv Yardena , Fattal Eyal , Liberzon Alex 
Published: May 2019

AbstractDirect estimation of Lagrangian turbulence statistics is essential for the proper modeling of dispersion and transport in highly obstructed canopy flows. However, Lagrangian flow measurements demand very high rates of data acquisition, resulting in bottlenecks that prevented the estimation of Lagrangian statistics in canopy flows hitherto. We report on a new extension to the 3D Particle Tracking Velocimetry (3D-PTV) method, featuring real-time particle segmentation that outputs centroids and sizes of tracer particles and performed on dedicated hardware during high-speed digital video acquisition from multiple cameras. The proposed extension results in four orders of magnitude reduction in data transfer rate that enables to perform substantially longer experimental runs, facilitating measurements of convergent statistics. The extended method is demonstrated through an experimental wind tunnel investigation of the Lagrangian statistics in a heterogeneous canopy flow. We observe that acceleration statistics are affected by the mean shear at the top of the canopy layer and that Lagrangian particle dispersion at small scales is dominated by turbulence in the wake of the roughness elements. This approach enables to overcome major shortcomings from Eulerian-based measurements which rely on assumptions such as the Taylor’s frozen turbulence hypothesis, which is known to fail in highly turbulent flows.
A case-control study of Metallothionein-1 expression in breast cancer and breast fibroadenoma
Authors: Sampaio Fabiane Araújo , Martins Luana Mota , Dourado Carla Solange de Melo Escorcio , Revoredo Camila Maria Simplício , Costa-Silva Danylo Rafhael , Oliveira Victor Alves de , Alves-Ribeiro Francisco Adelton , Silva Benedito Borges da 
Published: May 2019

AbstractThe overexpression of Metallothionein-1 (MT-1) may play an important role in breast cancer; however, few studies have compared MT-1 expression between breast cancer and fibroadenoma. A cross-sectional controlled study was performed in 66 premenopausal women, aged 20–49 years, who had been histologically diagnosed with breast fibroadenoma or breast cancer. The patients were divided into two groups: group A, control (fibroadenoma, n = 36) and group B, study (breast cancer, n = 30). Immunohistochemistry was performed on tissue samples of fibroadenoma and breast cancer patients to evaluate the expression of metallothionein using an anti-MT-1 polyclonal antibody (rabbit polyclonal anti-metallothionein-Catalog Number biorbyt-orb11042) at a dilution of 1:100. The data were analyzed using NOVA (p < 0.05). Microscopic analysis showed a higher concentration of anti-MT-1-stained nuclei in breast cancer tissues than in fibroadenoma tissues. The mean proportion of cells with anti-MT-1-stained nuclei was 26.93% and 9.10%, respectively, in the study and control groups (p < 0.001). Histological grade 3 tumors showed a significantly higher MT-1 expression than hitological grade 1 (p < 0.05), while breast tumors negative for estrogen-, progesterone- and HER2- receptors had a significantly higher MT-1 expression than positive breast tumors positive for these parameters (p < 0.05). MT-1 protein in women of reproductive age was significantly higher in breast cancer than in fibroadenoma in this study. Furthermore, there was higher MT-1 immunoreactivity in more aggressive tumors.
A comparison between spinal cord infarction and neuromyelitis optica spectrum disorders: Clinical and MRI studies
Authors: Hsu Jung Lung , Cheng Mei-Yun , Liao Ming-Feng , Hsu Hui-Ching , Weng Yi-Ching , Chang Kuo-Hsuan , Chang Hong-Shiu , Kuo Hung-Chou , Huang Chin-Chang , Lyu Rong-Kuo , Lin Kun-Ju , Ro Long-Sun 
Published: May 2019

AbstractThis study aims to investigate the clinical features and magnetic resonance imaging (MRI) findings in patients with spinal cord infarction (SCI) and neuromyelitis optica spectrum disorders (NMOSDs). Over a period of 16 years, we retrospectively analyzed 39 patients with SCI and 21 patients with NMOSD. The demographic features and clinical presentations of both diseases were carefully documented. Etiology-specific MRI features, such as the length and distribution of the lesions, the owl’s eyes sign and bright spotty lesions, were recorded and analyzed regarding their association with the clinical signs/symptoms. Patients with SCI were older than patients with NMOSD and had sudden onset of clinical symptoms with focal pain adjacent to the lesions. Concomitant spinal cord and vertebral body infarctions were frequently associated with aortic pathology (p = 0.04). In addition, artery dissection was highly associated with combined ASA and unilateral PSA infarctions and long segments of SCI (all p < 0.05). In contrast, patients with NMOSD had a relatively younger age of onset, female predominance and subacute progression of limbs weakness. As observed by MRI, the length and location of the lesions demonstrated significant differences between the two diseases (P < 0.01). The owl’s eyes sign showed more frequently in patients with SCI than NMOSD (p < 0.01). The predicted prognoses in SCI and NMOSD were significantly associated with initial motor function (muscle power), after adjustments for age and gender (p < 0.01 and p = 0.02, respectively). Along with patient demographic characteristics, lesion features on MRI can help clinicians differentiate acute noncompressive myelopathy due to SCI from that due to NMOSD, which may lead to immediate initiation of adequate therapeutic measures.