bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chances of Improvement in Cases of Vestibular Schwannoma Presenting with Facial Nerve Weakness: Presentation of Two Cases and Literature Review
Authors: Rizk Ahmed , Mehlitz Marcus , Bettag Martin 
Published: July 2018

Background and Study Aim Facial nerve (FN) weakness as a presenting feature in vestibular schwannoma (VS) is extremely rare. We are presenting two different cases of VS with significant facial weakness and reviewed the literature for similar cases.
Methods and Results We are presenting two cases of VS with significant facial weakness. The first case was a 63-year-old male patient presented with 3 weeks' history of severe left-sided facial weakness (House–Brackmann [HB] grade V) and hearing loss. Magnetic resonance imaging (MRI) of the brain showed a tumor in the left internal auditory canal. Gross total removal with anatomical and physiological FN preservation was performed through a retrosigmoid approach under neurophysiological monitoring. FN function improved postoperatively to HB grade II after 16 months. The other case was 83-year-old male patient presented with sudden left-sided hearing loss and severe facial weakness (HB grade V). MRI of the brain 2.5 years before showed a left-sided (Class-T3A) cystic VS. The tumor was asymptomatic; wait-and-scan strategy was advised by the treating neurologist. Recent MRI of the brain showed approximately three times enlargement of the tumor with brain stem compression, extensive cystic changes, and suspected intratumoral hemorrhage. Surgery was performed; the tumor was subtotally removed through a retrosigmoid approach with intraoperative FN monitoring. The FN was anatomically preserved; however, physiological preservation was not possible. Severe facial weakness with incomplete lid closure persisted postoperatively.
Conclusion Surgical treatment could be offered to cases of suspected VS presenting with facial weakness, as these cases may still have a chance for improvement especially in laterally located tumors.
Diffuse Loss of Vertebral Body Height and Marrow Changes in a 4-Year-Old with Acute Lymphoblastic Leukemia
Authors: Hostmeyer Sean , Massak Mark , Cauley Keith A. 
Published: July 2018

AbstractAcute leukemia can present with a wide range of symptoms and with no classic osseous findings on radiographs. Recognizing subtle imaging abnormalities and raising the possibility of a lymphoproliferative or hematologic pathology may facilitate early diagnosis. Described here is a case of a 4-year-old with back pain that was found to have acute lymphoblastic leukemia with diffuse loss of vertebral body height on plain film radiographs, and with prominent discs, and diffusely abnormal marrow signal on magnetic resonance imaging.
Upper Extremity Catheter Angiography: Indications, Techniques, Anatomy, and Classic Cases
Authors: Shin David , Magill David , Johnson Guy , Ingraham Christopher , Kogut Matthew , Monroe Eric 
Published: July 2018

AbstractCatheter arteriography of the upper extremity has become an infrequent procedure in modern practice given the advancements in computed tomography/magnetic resonance angiography (CT/MRA). However, catheter angiography continues to have major diagnostic and interventional roles in certain pathophysiologic conditions. This article discusses the indications and techniques of upper extremity catheter angiography, and presents classic cases to demonstrate key anatomic, diagnostic, and interventional considerations.
Pech mit der Gesundheit – Glück in der Krankheit
Authors: Leidinger Friedrich 
Published: July 2018

ZusammenfassungAusgehend von ihrer Begriffsgeschichte werden Gesundheit und Krankheit als unterschiedliche Formen menschlicher Existenz beschrieben, die sich nicht gegenseitig verneinen. Eine Kasuistik zeigt, dass auch von einer schweren Erkrankung mit eingeschränkter Lebensqualität und -zeit Betroffene Glück und Erfüllung erleben können. Als Voraussetzungen hierfür werden eine offene Suchhaltung („Serendipity“), Kohärenz, Empowerment und ein an den Erfahrungen der Selbsthilfe orientiertes Behandlungsziel („Recovery“) beschrieben. Die Herausforderungen für das psychiatrische Hilfesystem werden diskutiert.
The Grand Projet politics of an urban age: urban megaprojects in Asia and Europe
Authors: Hanakata Naomi C. , Gasco Anna 
Published: July 2018

AbstractThis paper presents a comprehensive study of large-scale, master-planned urban developments in Asia and Europe. Increasing in numbers all over the world since the 1980’s, these urban mega-projects—here referred to asGrands Projets—have become major drivers of urban intensification. Set forth to actuate urban renewal or to augment city expansion,Grands Projetshave become spatial manifestations of cities’ larger economic and political agendas. In their development process, they have triggered a change in the urban condition beyond the very boundaries of their sites. As such, they offer a productive means of investigating current urban trends in a globally connected form of concentrated urbanisation. This research, based at the ETH-Future Cities Laboratory (FCL) in Singapore, examines eight case studies in Asia and Europe through five analytical frames: a project’s conception, design, implementation, operation and implications. This approach addresses various spatial and temporal scales within different theoretical and material practices, allowing a comprehensive discussion ofGrands Projetswithin and across varying socio-political contexts. This paper sheds light on the specific urban conditions ofGrands Projetsdespite their global development trends, transnational owners or financing alliances and internationally regulated planning practices. Often dependent on exceptional regulations outside statutory planning procedures, they are subject to context-specific challenges, project-specific briefs and unique configurations of actors and stakeholders, all of which have created different manifestations ofGrands Projetsin space. This analytical framework, as presented in this paper, will form the basis of a larger comparative endeavour to be completed at a later stage in our work.
Porous carbon-based adsorption systems for natural gas (methane) storage
Authors: Tsivadze Aslan Yu. , Aksyutin Oleg E. , Ishkov Alexander G. , Men’shchikov Ilya E. , Fomkin Anatoly A. , Shkolin Andrey V. , Khozina Elena V. , Grachev Vladimir A. 
Published: July 2018

The use of gas fuel has considerable environmental advantages over traditional types of fuel based on petroleum products or fossil coal. The adsorption technology for methane (natural gas) uptake, storage and transportation can serve as a connecting link in gas supply to customers. The review considers characteristics of adsorption systems for methane storage. The key methods used for the synthesis of microporous carbon adsorbents based on various organic and inorganic carbon-containing compounds are described. Methods for increasing the efficiency of methane storage systems based on carbon adsorbents are analyzed. Theoretical approaches to optimization of the properties of methane – carbon adsorbent systems are discussed.
The bibliography includes 174 references.
Inchworm movement of two rings switching onto a thread by biased Brownian diffusion represent a three-body problem
Authors: Benson Christopher R. , Maffeo Christopher , Fatila Elisabeth M. , Liu Yun , Sheetz Edward G. , Aksimentiev Aleksei , Singharoy Abhishek , Flood Amar H. 
Published: July 2018

SignificanceThis article describes a molecular realization of the classical three-body problem, where the motion of three or more bodies is directed by a set of pairwise forces. Surprisingly, motion of the components of the three-body molecular systems is found to be highly choreographed by differences in strength of intercomponent interactions, promoting a rare inchworm-like loading of molecular rings onto a molecular thread. Our work demonstrates the utility of an integrative approach to design and develop functional molecular machines.
Vibration and Mode Shape Analysis of Functionally Graded Nanocomposite Plates Reinforced by Aggregated Carbon Nanotube
Authors: Tahouneh Vahid 
Published: July 2018

Abstract
In the present work, by considering the agglomeration effect of single-walled carbon nanotubes, free vibration characteristics of functionally graded (FG) nanocomposite plates is presented. The volume fractions of randomly oriented agglomerated single-walled carbon nanotubes (SWCNTs) are assumed to be graded in the thickness direction. To determine the effect of CNT agglomeration on the elastic properties of CNT-reinforced composites, a two-parameter micromechanical model of agglomeration is employed. The effects of geometrical and material parameters on the frequency parameters of the FG nanocomposite plates are investigated. For an overall comprehension on 3-D vibration of rectangular plates, some mode shape contour plots are reported in this research work.
Last resort lending before Henry Thornton? The Bank of England’s role in containing the 1763 and 1772–1773 British credit crises
Authors: Kosmetatos Paul 
Published: July 2018

AbstractClaims that the Bank of England began to act as a Lender of Last Resort as early as the mid-eighteenth century date back to Adam Smith and Henry Thornton. This article presents evidence on the Bank’s financial market interventions during the 1763 and 1772–1773 crises, and concludes that although the former was too gradual to be truly representative of last resort lending by 1772 the means of intervention described by Thornton were largely in place. Although direct evidence for the Bank’s decision making process on either occasion is lacking, the universal contemporary conviction of its unique resources and obligations make it unlikely that it was entirely motivated by political considerations or cronyism. Its actions are instead consistent with Thornton’s crisis containment narrative of banknote loans to London bankers, which in turn was the optimal response for containing financial contagion by ensuring the continued health of the bills of exchange network.
A solution method for treatment scheduling in rehabilitation hospitals with real-life requirements
Authors: Xiao Liyang , Dridi Mahjoub , Hajjam El Hassani Amir , Lin Wanlong , Fei Hongying 
Published: July 2018

Abstract
In this study, we aim to minimize the total waiting time between successive treatments for inpatients in rehabilitation hospitals (departments) during a working day. Firstly, the daily treatment scheduling problem is formulated as a mixed-integer linear programming model, taking into consideration real-life requirements, and is solved by Gurobi, a commercial solver. Then, an improved cuckoo search algorithm is developed to obtain good quality solutions quickly for large-sized problems. Our methods are demonstrated with data collected from a medium-sized rehabilitation hospital in China. The numerical results indicate that the improved cuckoo search algorithm outperforms the real schedules applied in the targeted hospital with regard to the total waiting time of inpatients. Gurobi can construct schedules without waits for all the tested dataset though its efficiency is quite low. Three sets of numerical experiments are executed to compare the improved cuckoo search algorithm with Gurobi in terms of solution quality, effectiveness and capability to solve large instances.
Association of Metabolic, Inflammatory, and Tumor Markers With Circulating Tumor Cells in Metastatic Breast Cancer
Authors: Lohmann Ana Elisa , Dowling Ryan J O , Ennis Marguerite , Amir Eitan , Elser Christine , Brezden-Masley Christine , Vandenberg Theodore , Lee Elma , Fazaee Kamran , Stambolic Vuk , Goodwin Pamela J , Chang Martin C 
Published: July 2018

Abstract

Background
Circulating tumor cells (CTCs) are associated with worse prognosis in metastatic breast cancer (BC). We evaluated the association of metabolic, inflammatory, and tumor markers with CTCs in women with metastatic BC before commencing a new systemic therapy.

Methods
Ninety-six patients with newly diagnosed or progressing metastatic BC without current diabetes or use of anti-inflammatory agents were recruited from four Ontario hospitals. Women provided fasting blood for measurement of metabolic, inflammatory, and tumor markers and CTCs. CTCs were assayed within 72 hours of collection using CellSearch. Other blood was frozen at –80°C, and assays were performed in a single batch. Associations between CTC counts with study factors were evaluated using Spearman correlation, and the chi-square or Fisher exact test. All statistical tests were two-sided and P value ≤ .05 was considered statistically significant.

Results
The median age was 60.5 years; 90.6% were postmenopausal. The cohort included hormone receptor–positive (87.5%), HER2–positive (15.6%), and triple-negative (10.4%) BCs. Patients were starting firstline (35.5%), second-line (26.0%), or third-or-later-line therapy (38.5%). CTC counts (per 7.5 mL of blood) ranged from 0 to 1238 (median 2); an elevated CTC count, defined as five or more CTCs, was detected in 42 (43.8%) patients. Those with liver metastases (vs not) more frequently had an elevated CTC count (59.0% vs 33.3%, P = .02). CTCs were significantly associated with C-reactive protein (R = .22, P = .02), interleukin (IL)-6 (R = .25, P = .01), IL-8 (R = .38, P = .0001), plasminogen activator inhibitor 1 (R = .31, P = .001), carcinoembryonic antigen (R = .31, P = .002), and cancer antigen 15-3 (R = .40, P = .0001) and inversely associated with body mass index (R = –.23, P = .02) and leptin (R = –.26, P = .01).

Conclusions
CTC counts were positively associated with tumor and inflammatory markers and inversely associated with some metabolic markers, potentially reflecting tumor burden and cachexia.
The Relationship Between Census Tract Poverty and Shiga Toxin–Producing E. coli Risk, Analysis of FoodNet Data, 2010–2014
Authors: Hadler James L , Clogher Paula , Huang Jennifer , Libby Tanya , Cronquist Alicia , Wilson Siri , Ryan Patricia , Saupe Amy , Nicholson Cyndy , McGuire Suzanne , Shiferaw Beletshachew , Dunn John , Hurd Sharon 
Published: July 2018

Abstract

Background
The relationship between socioeconomic status and Shiga toxin–producing Escherichia coli (STEC) is not well understood. However, recent studies in Connecticut and New York City found that as census tract poverty (CTP) decreased, rates of STEC increased. To explore this nationally, we analyzed surveillance data from laboratory-confirmed cases of STEC from 2010–2014 for all Foodborne Disease Active Surveillance Network (FoodNet) sites, population 47.9 million.

Methods
Case residential data were geocoded and linked to CTP level (2010–2014 American Community Survey). Relative rates were calculated comparing incidence in census tracts with &lt;20% of residents below poverty with those with ≥20%. Relative rates of age-adjusted 5-year incidence per 100 000 population were determined for all STEC, hospitalized only and hemolytic-uremic syndrome (HUS) cases overall, by demographic features, FoodNet site, and surveillance year.

Results
There were 5234 cases of STEC; 26.3% were hospitalized, and 5.9% had HUS. Five-year incidence was 10.9/100 000 population. Relative STEC rates for the &lt;20% compared with the ≥20% CTP group were &gt;1.0 for each age group, FoodNet site, surveillance year, and race/ethnic group except Asian. Relative hospitalization and HUS rates tended to be higher than their respective STEC relative rates.

Conclusions
Persons living in lower CTP were at higher risk of STEC than those in the highest poverty census tracts. This is unlikely to be due to health care–seeking or diagnostic bias as it applies to analysis limited to hospitalized and HUS cases. Research is needed to better understand exposure differences between people living in the lower vs highest poverty-level census tracts to help direct prevention efforts.
Bridging the academic and practice/policy gap in public health: perspectives from Scotland and Canada
Authors: McAteer J , Di Ruggiero E , Fraser A , Frank J W 
Published: July 2018

Abstract
This article presents a critical commentary of specific organizational models and practices for bridging ‘the gap’ between public health research and policy and practice. The authors draw on personal experiences of such models in addition to the wider knowledge translation and exchange literature to reflect on their strengths and weaknesses as implemented in Scotland and Canada since the early 1990s.
Validation of 2 Submaximal Cardiorespiratory Fitness Tests in Patients With Breast Cancer Undergoing Chemotherapy
Authors: Mijwel Sara , Cardinale Daniele , Ekblom-Bak Elin , Sundberg Carl Johan , Wengström Yvonne , Rundqvist Helene 
Published: July 2018

Background:
Patients with breast cancer have an impaired cardiorespiratory fitness, in part, due to the toxic effects of anticancer therapy. Physical exercise as a means of rehabilitation for patients with cancer is an emerging area of research and treatment, emphasizing the need for accurate and feasible physical capacity measurements. The purpose of this study was to evaluate the validity of peak oxygen consumption (

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2peak) predicted by the Ekblom-Bak test (E-B) and the Åstrand-Rhyming prediction model (A-R).

Methods:
Eight patients with breast cancer undergoing chemotherapy participated in the study. Submaximal exercise tests were performed at 2 different submaximal workloads. Estimated

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2peak values were obtained by inserting the heart rate (HR) from the 2 workloads into the E-B prediction model and the HR of only the higher workload into the Åstrand nomogram. A 20-W incremental cycle test-to-peak effort was performed to obtain

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2peak values.

Results:
Results from A-R overestimated

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2peak by 6% (coefficient of variation = 7%), whereas results from E-B overestimated

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2peak with 42% (coefficient of variation = 21%) compared with measured

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2peak. Pearson's correlation coefficient revealed a significant strong relationship between the estimated

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2peak from A-R and the measured

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2peak (r = 0.86; P < .05), whereas the relationship between the estimated

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2peak from E-B and the measured

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2peak resulted in a nonsignificant weak correlation (r = 0.21).

Conclusion:
In a situation where maximal exercise testing is not practical or undesirable from a patient safety perspective, submaximal exercise testing provides an alternative way of estimating

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2peak. The A-R prediction model appears to be a valid submaximal exercise test for determining cardiorespiratory fitness in this population.
Safety of Symptom-Based Modification of Physical Therapy Interventions in Pediatric Oncology Patients With and Without Low Blood Counts
Authors: Gilchrist Laura , Tanner Lynn R. 
Published: July 2018

Background:
Pediatric patients being treated for cancer often have low blood counts, yet physical therapy (PT) intervention and activity during treatment are thought to be important. The current practice at one institution is to modify PT interventions based on symptoms rather than relying on complete blood cell (CBC) counts.

Purpose:
This study investigates the safety of a symptomatic, rather than count-based, approach to modification of PT interventions in a pediatric cancer population at least 2 months into treatment.

Methods:
A retrospective chart review was performed to investigate the number and type of adverse events that occurred within 48 hours of a PT session in pediatric oncology patients. Information related to CBC values and type of interventions was abstracted from medical records. Associations between adverse events and low hemoglobin, platelets, and white blood cell (WBC) counts were assessed, and risk ratios were calculated.

Results:
CBC values were often abnormal. Adverse events occurred during or after 37 of 406 PT sessions, with the most common event being tachycardia not requiring medical intervention. No serious adverse events occurred. While an increased number of events occurred in those with low hemoglobin levels, this was nonsignificant when tachycardia was removed. A higher rate of adverse events did occur when platelets were below 20 000/mm3 (χ2 = 11.08, P = .001; Risk Ratio = 4.91; 95% confidence interval, 1.76-13.67), although none were bleeding-related. Low WBC count was not associated with an increased risk of adverse events.

Conclusion:
PT interventions can be safely incorporated into patient care when symptoms, rather than CBC values, guide clinical decision making about treatment modification.
Opioid Campaigns' Impact on Advanced Cancer and Hospice and Palliative Care: An Invited Commentary
Authors: Wilson Christopher M. 
Published: July 2018

Background:
Opioids effectively manage pain, but increasing misuse has resulted in significant abuse, addiction, and even death. This misuse has accelerated to the point that an “opioid epidemic” has been declared. Several government agencies and professional associations (including the APTA) are developing well-meaning programs to address opioid abuse.

Purpose:
Recent national opioid campaigns may have significant, unintentional, and adverse consequences on the medical management of patients with advanced cancers or those receiving hospice and palliative care (HPC). This commentary describes the role of the physical therapist (PT) in the palliative symptom management of terminally ill individuals during this paradigm shift in opioid-prescribing practices.

Discussion:
Opioids have long been a staple in the management of symptoms present in patients with advanced cancer or in HPC (ie, pain, dyspnea). New opioid management guidelines are likely to impose even tighter controls on opioids, further reducing accessibility to these drugs for these individuals. There is concern that these well-meaning public initiatives may have unintended consequences for end-of-life care if the HPC community is not vigilant in its advocacy. The expected reduction in opioid prescriptions prompts an increasingly critical role for PTs in palliative symptom management to optimize remaining quality of life.

Conclusion:
During refinement of policies, procedures, and legislation related to medical use of opioids, health care providers (including PTs) caring for individuals with a life-threatening illness must provide input to regulatory bodies in order to avoid overly restrictive regulations that may increase pain and suffering near the end of life.