bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of organic agriculture development in Asian countries
Authors: Khoruzhy L I , Kagirova M V , Kirillova S S , Romantseva Yu N , Anokhin I A 
Published: November 2024

Abstract
The implementation of Sustainable Development Goals stimulates the use of new innovative technologies in production processes of the most resource-intensive types of economic activity in most countries of the world. The modern agricultural sector, which uses land and water resources to ensure food security in countries, aims to preserve soil fertility, the quality of water resources, air and biodiversity. That is why organic agriculture is gaining popularity not only in developed, but also in lower-income countries, including Asian countries. In recent years, countries such as China and India have increased the production of various types of products several times; moreover, their consumption is constantly increasing, which is the basis for achieving the goal of preserving the health of the nation. The study is aimed at identifying natural and economic factors in the development of production, consumption and export of organic products; existing risks. The choice of the object of study is due to the fact that China, India and Indonesia are the leading countries, among the top ten countries in terms of population, these countries are large in extent, in other words, the size of their territory allows them to produce various types of agricultural products; Vietnam and Thailand were chosen due to the fact that the countries are quite unique in terms of climatic conditions, which is why they produce unique types of products and have been actively increasing the production of organic products in recent years. Based on the methods of structural and comparative analysis, aligning time series, stable trends towards an increase in export volumes were identified, and the reasons for the increase in the production of organic products were substantiated.
Microplastics and Climate Change: Analyzing the Environmental Impact and Mitigation Strategies
Authors: Abdullayeva Maya , Yaqubov Ramil 
Published: November 2024

Abstract
Plastics have become integral to modern society due to their versatility and economic benefits, resulting in unprecedented global production levels. However, this convenience comes at a significant environmental cost, with plastic pollution posing severe threats to ecosystems and human health. Amidst growing concerns, the COVID-19 pandemic has exacerbated the plastic pollution crisis, particularly with the surge in single-use plastic consumption. Moreover, the insidious role of plastics in exacerbating climate change is increasingly recognized, with plastic-related greenhouse gas emissions presenting a significant challenge to global climate goals. This article analyzes the direct and indirect contributions of plastic to greenhouse gas emissions, encompassing various waste management methods and the production lifecycle of plastics. Through a comprehensive assessment, the urgent need for intervention strategies to mitigate the consequences of plastic pollution and its climate-related impacts is determined. Efforts to reduce plastic’s impact on climate include promoting bio-based alternatives, transitioning to low-carbon production methods, banning single-use plastics, and improving waste management practices. By adopting these strategies, we can address the detrimental impact of plastic pollution on our planet and climate, moving towards a more sustainable future.
Judges
Authors: He Xin 
Published: November 2024

Abstract
Chapter 2 scrutinizes the judges’ work, exploring their backgrounds, responsibilities, and aspirations. It highlights the impact of recent legal professionalism reforms, which have increased state control over judges, making them more accountable than independent. The chapter distinguishes between legitimate and illegitimate extralegal influences on judges, arguing that the decline of the latter has led to an increase in the former. It examines the impacts of these influences on judges’ workloads, promotions, and prestige, and notes a shift from hierarchical to panoptic control. Overall, Chapter 2 provides a vivid and penetrating analysis of the experiences and challenges facing judges in China’s evolving judicial system.
People’s Assessors
Authors: He Xin 
Published: November 2024

Abstract
Chapter 3 focuses on the role of people’s assessors in China’s judicial system. It examines recent reforms aimed at enhancing their decision-making power and explores the impact of the new Assessors’ Law. The chapter highlights the dilemma facing the institution, as the regime wants to present an image of judicial democracy but cannot afford to lose control. Despite significant investments and efforts to improve the assessors’ role, progress remains limited. The impact of lay participation is rather limited. The lay assessors deliberate together with the judges and thus are heavily influenced by them; more importantly, the state tightly controls the courts’ decision-making process, further minimizing lay assessors’ impact. Overall, Chapter 3 provides a sharp analysis of the challenges facing people’s assessors in China’s evolving judicial system.
Civil Justice
Authors: He Xin 
Published: November 2024

Abstract
Chapter 6 examines how Chinese courts handle civil cases. The chapter finds that, while the courts have incorporated some adversarial elements, state control has pushed them toward inquisitorialism. The chapter also highlights the outcome gap between those who have and have not, and the regime’s efforts to enhance legitimacy. Despite challenges, the chapter concludes that China’s courts have significantly improved their performance in handling civil cases, with local protectionism declining and enforcement of judgments becoming more effective, although the latter may come at the expense of fundamental rights. Several reasons for the decline in local protectionism, including the diversification of China’s economy, are explored in the chapter.
Criminal Justice
Authors: He Xin 
Published: November 2024

Abstract
Chapter 8 examines the impact of recent reforms on China’s criminal justice system, which has traditionally been shaped by the iron triangle of police, procuratorate, and courts. It argues that the plea leniency system, driven by efficiency and stability concerns, has positioned the procuratorate at center stage, further marginalizing the courts. Additionally, the death penalty is manipulated to bolster legitimacy and maintain stability, aligning with the decline of wrongful convictions and the trend of leniency. This chapter reveals how recent reforms have shifted power dynamics within the criminal justice system, emphasizing the role of the procuratorate and the strategic use of leniency.
Conclusion
Authors: He Xin 
Published: November 2024

Abstract
The Conclusion highlights the heightened focus on law in the official discourse of the Chinese party-state. It raises critical questions about whether such emphasis is merely a pretext for further control by an authoritarian state, and whether the rule of law can genuinely take root in China. The Conclusion argues that, while judges are likely to become more professional, they are not expected to deviate from the current, highly instrumentalist paradigm. It is unlikely that the Singaporean model, in which the laws are professionally practiced in civil and commercial cases, but a high value is placed on “social order” and “state stability” in political and constitutional matters, will be adopted in China. The policy-implementing nature of Chinese courts will likely persist, with rights protection serving the state’s legitimacy and governance.
Responses in adult pied flycatcher males depend on playback song similarity to local population
Authors: Gallego-Abenza Mario , Kraft Fanny-Linn H , Ma Lan , Rajan Samyuktha , Wheatcroft David 
Published: November 2024

Abstract
Song divergence driven by social learning has been proposed to be a key factor driving allopatric speciation in oscine birds. Songbirds often respond more to songs deriving from their local population, suggesting the potential for acoustic divergence across populations to shape both intra- and intersexual interactions. However, many of these studies were conducted on species with simple songs and, as a result, we know comparatively little about the emergence of population differences and song discrimination in species with complex songs. We addressed this question in the pied flycatcher (Ficedula hypoleuca) by calculating the dissimilarity of songs from 2 foreign populations as well as from our study site to the local centroid. We then conducted a paired-design playback experiment where both local and foreign songs were played simultaneously. We found that pied flycatcher males showed significantly stronger responses to those songs that sounded more similar to the local population. This suggests that despite the high complexity of the pied flycatcher song, individuals are still able to discriminate across populations. Our results support the hypothesis that learned song divergence can act as a mechanism for assortative mating and allopatric speciation.
siRNADiscovery: a graph neural network for siRNA efficacy prediction via deep RNA sequence analysis
Authors: Long Rongzhuo , Guo Ziyu , Han Da , Liu Boxiang , Yuan Xudong , Chen Guangyong , Heng Pheng-Ann , Zhang Liang 
Published: November 2024

Abstract
The clinical adoption of small interfering RNAs (siRNAs) has prompted the development of various computational strategies for siRNA design, from traditional data analysis to advanced machine learning techniques. However, previous studies have inadequately considered the full complexity of the siRNA silencing mechanism, neglecting critical elements such as siRNA positioning on mRNA, RNA base-pairing probabilities, and RNA–AGO2 interactions, thereby limiting the insight and accuracy of existing models. Here, we introduce siRNADiscovery, a Graph Neural Network (GNN) framework that leverages both non-empirical and empirical rule-based features of siRNA and mRNA to effectively capture the complex dynamics of gene silencing. On multiple internal datasets, siRNADiscovery achieves state-of-the-art performance. Significantly, siRNADiscovery also outperforms existing methodologies in in vitro studies and on an externally validated dataset. Additionally, we develop a new data-splitting methodology that addresses the data leakage issue, a frequently overlooked problem in previous studies, ensuring the robustness and stability of our model under various experimental settings. Through rigorous testing, siRNADiscovery has demonstrated remarkable predictive accuracy and robustness, making significant contributions to the field of gene silencing. Furthermore, our approach to redefining data-splitting standards aims to set new benchmarks for future research in the domain of predictive biological modeling for siRNA.
CCR8/CCL1 and CXCR3/CXCL10 axis-mediated memory T-cell activation in patients with recalcitrant drug-induced hypersensitivity
Authors: Chiu Tsu-Man , Chen Chun-Bing , Lu Chun-Wei , Hui Rosaline Chung-Yee , Chi Min-Hui , Chang Ya-Ching , Wu Jennifer , Chen Kuan-Yu , Lin Yang Yu-Wei , Lo Pei-Chi , Hsu Tsai-Ching , Wang Chuang-Wei , Chung Wen-Hung 
Published: November 2024

Abstract

Background
As a drug-induced hypersensitivity syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS) is potentially fatal. Most patients with DRESS recover within a few weeks; however, some patients may suffer from a prolonged disease course and develop autoimmune sequelae.

Objectives
To investigate the immune mechanism and therapeutic targets of patients with recalcitrant DRESS with a prolonged disease course.

Methods
Thirty-two patients with recalcitrant DRESS with a prolonged treatment course (≥ 8 weeks; ‘prolonged DRESS’), 28 patients with DRESS with a short treatment course (&lt; 2 weeks; ‘short-duration DRESS’) and 26 healthy donors (HDs) were enrolled.

Results
Bulk transcriptome results showed that the mRNA expression levels of CCR8 and CXCR3 were significantly increased in blood samples from patients in the acute stage of prolonged DRESS [Padj = 1.50 × 10–9 (CCR8) and Padj = 2.60 × 10–4 (CXCR3), patients with prolonged DRESS compared with the HD group]. Serum and skin lesion concentrations of CCL1 and CXCL10 (ligands of CCR8 and CXCR3, respectively) were significantly increased in patients with prolonged DRESS compared with patients with short-duration DRESS. The results from high-parameter flow cytometry and autoantibody screening also identified significant increases in CD8+ GNLY+ CXCR3+ effector memory T cells, CD8+ central memory T cells, CD4+ CCR8+ T helper 2 cells and IgG anti-HES-6 autoantibodies in patients with prolonged DRESS. Furthermore, in vitro blocking assays revealed that Janus kinase inhibitors (JAKi; mainly tofacitinib and upadacitinib) significantly decreased the release of CCL1 and CXCL10. Some patients with prolonged DRESS were successfully treated with JAKi.

Conclusions
JAKi (tofacitinib and upadacitinib) were associated with decreased concentrations of CCL1 and CXCL10, suggesting that they may attenuate CCR8/CCL1 and CXCR3/CXCL10 axis-mediated memory T-cell activation, which contributes to disease pathogenesis in patients with recalcitrant DRESS and a long-term treatment course.

Graphical Abstract
Understanding Different Forms of Gun Violence in American Schools: An Analysis from 1980 to 2019
Authors: Hamlin Daniel E 
Published: November 2024

Abstract
Scholars theorize that the nature of school gun violence varies across school settings. Yet, there is a lack of statistical research testing this idea. This study investigates contextual factors associated with six forms of school gun incidents (N = 1,238) over a 40-year period (1980–2019) in the United States. To conduct the analyses, school, community, and state-level data were linked to school gun incidents recorded in a comprehensive K–12 school gun violence database. Results indicate that the most common form of school gun violence stems from school-related conflicts. Gun incidents from school-related conflicts (odds ratio [OR] = 2.22, p &lt; .01) and suicides (OR = 3.08, p &lt; .01) are also more likely to occur in high schools. Large cities (OR = 4.75, p &lt; .001), midsize cities (OR = 2.35, p &lt; .01), and suburbs (OR = 2.74, p &lt; .05) report more school gun violence driven by criminal activity, whereas school gun violence from suicide and indiscriminate school shootings has a higher probability of occurring in rural schools and areas with comparatively low poverty. This study offers suggestive evidence that an emphasis on alleviating school conflicts may reduce school gun violence overall but that separate strategies may also be needed across different types of school contexts.
Positive definite functions on a regular domain
Authors: Buhmann Martin , Xu Yuan 
Published: November 2024

Abstract
We define positive and strictly positive definite functions on a domain and study these functions on a list of regular domains. The list includes the unit ball, conic surface, hyperbolic surface, solid hyperboloid and the simplex. Each of these domains is embedded in a quadrant or a union of quadrants of the unit sphere by a distance-preserving map, from which characterizations of positive definite and strictly positive definite functions are derived for these regular domains.
The ABCDs of Nutritional Assessment in Infectious Diseases Research
Authors: Locks Lindsey M , Parekh Aneri , Newell Katharine , Dauphinais Madolyn R , Cintron Chelsie , Maloomian Kimberly , Yu Elaine A , Finkelstein Julia L , Mehta Saurabh , Sinha Pranay 
Published: November 2024

Abstract
Malnutrition is the most common acquired cause of immunodeficiency worldwide. Nutritional deficiencies can blunt both the innate and adaptive immune response to pathogens. Furthermore, malnutrition is both a cause and consequence of infectious diseases. The bidirectional relationship between infectious diseases and undernutrition, as well as the inflammatory milieu of infectious diseases, can complicate nutritional assessment. This article aims to provide clinicians and researchers with an overview of commonly used tools to assess nutritional status, with a particular emphasis on their use in the context of infectious diseases. These tools include anthropometric, biochemical, clinical/physical, and dietary assessments to screen and evaluate undernutrition, diet quality, and food insecurity effectively.
The role of routine and structured social needs data collection in improving care in US hospitals
Authors: Richwine Chelsea , Patel Vaishali , Everson Jordan , Iott Bradley 
Published: November 2024

Abstract

Objectives
To understand how health-related social needs (HRSN) data are collected at US hospitals and implications for use.

Materials and Methods
Using 2023 nationally representative survey data on US hospitals (N = 2775), we described hospitals’ routine and structured collection and use of HRSN data and examined the relationship between methods of data collection and specific uses. Multivariate logistic regression was used to identify characteristics associated with data collection and use and understand how methods of data collection relate to use.

Results
In 2023, 88% of hospitals collected HRSN data (64% routinely, 72% structured). While hospitals commonly used data for internal purposes (eg, discharge planning, 79%), those that collected data routinely and in a structured format (58%) used data for purposes involving coordination or exchange with other organizations (eg, making referrals, 74%) at higher rates than hospitals that collected data but not routinely or in a non-structured format (eg, 93% vs 67% for referrals, P&lt; .05). In multivariate regression, routine and structured data collection was positively associated with all uses of data examined. Hospital location, ownership, system-affiliation, value-based care participation, and critical access designation were associated with HRSN data collection, but only system-affiliation was consistently (positively) associated with use.

Discussion
While most hospitals screen for social needs, fewer collect data routinely and in a structured format that would facilitate downstream use. Routine and structured data collection was associated with greater use, particularly for secondary purposes.

Conclusion
Routine and structured screening may result in more actionable data that facilitates use for various purposes that support patient care and improve community and population health, indicating the importance of continuing efforts to increase routine screening and standardize HRSN data collection.
Valorizing waste streams to enhance sustainability and economics in microbial oil production
Authors: Renegar Nicholas , Rhoades Seth , Nair Anusha , Sinskey Anthony J , Ward John P , Appleton David Ross 
Published: November 2024

Abstract

Driven by the demand for more sustainable products, research and capital investment has been committed to developing microbially produced oils. While researchers have shown oleaginous yeasts and other microbes can produce low-carbon footprint oils by leveraging waste streams as energy sources, previous analyses have not fully explored the quantity of available waste streams and in turn economy-of-scale enabled on capital and operating expenses. This paper makes parallels to 2G ethanol facilities, enabling a data-driven understanding of large-scale production economics. Production costs are broken down for a variety of scenarios. The analysis finds that reaching price parity with large-scale commodity oils (e.g., palm oil, high-oleic cooking oils, biofuels feedstock oils, lauric acid) is not possible today and unlikely even under aggressive future assumptions about strain productivity. Instead, commercial production must be targeted at end markets where sustainability-conscious consumers are willing to pay the price premiums identified in this paper.

One Sentence Summary
This paper makes parallels to 2G ethanol facilities, enabling a data-driven understanding of large-scale production economics for microbial lipids.
A rare case of tip appendicitis treated successfully with conservative management
Authors: Qunibi Hanan , Thalji Mariam , Ahmad Mutasem Sayyed , Fakhouri Sulaiman 
Published: November 2024

Abstract
Tip appendicitis is a rare and fatal complication after appendectomy. Diagnosing this condition requires a high level of suspicion due to its ambiguous and nonspecific symptoms. Radiological investigations such as ultrasound and computed tomography scans can aid in diagnosis. Early identification and treatment are of paramount importance for good patient outcomes. In most cases, Tip excision is the preferred treatment. However, antibiotics can also be a useful alternative. Conservative antibiotic treatment can be successful in certain situations, particularly when no fecaliths or perforation exists. Close monitoring is necessary to avoid the return of chronic appendicitis. We here introduce a case of a 47-year-old female patient who underwent an open appendectomy a year ago and is currently complaining of right lower quadrant abdominal pain. The patient was diagnosed with tip appendicitis. She was started on conservative antibiotic therapy and discharged home with good general conditions.
Ancient and Modern in Eighteenth-Century British Music Criticism: The Contradictory Case of Henry Purcell’s Te Deum and Jubilate
Authors: Herissone Rebecca 
Published: November 2024

ABSTRACT
During the early modern period, the Quarrel of the Ancients and Moderns encapsulated profound changes in the way people conceived of the past in relation to their own present. While the Ancients continued to advocate emulating esteemed ancient authorities, the Moderns sought to break away from previous models through original invention. In reality, this binary opposition disguises a much more gradual process of change, which often resulted in contradictory perspectives on the past. This article uses music criticism from eighteenth-century Britain to explore these complexities, concentrating on how Henry Purcell’s Te Deum and Jubilate was appropriated by authors from both sides of the Quarrel to advance opposing viewpoints, using embryonic musical analysis as a hermeneutic tool. The study exposes the tensions underlying the developing historical narratives on which Purcell’s posthumous reputation was built, allowing us to place our own understanding of his reception more firmly within its socio-cultural context.