bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Intensified Mode of Variability Modulating the Summer Heat Waves in Eastern Europe and Northern China
Authors: Deng Kaiqiang , Yang Song , Ting Mingfang , Lin Ailan , Wang Ziqian 
Published: October 2018

AbstractThis study investigates the leading pattern of Eurasian summer heat waves (HWs) using observed and simulated data sets and reveals an intensified mode of variability that bridges the HWs in eastern Europe (EE) and northern China (NC). The concurrent variability of the HWs in EE and NC is primarily driven by an atmospheric circum‐global teleconnection that induces anomalous anticyclones over the two regions. The observed upward trends in EE and NC HW days could be related to the warm sea surface temperatures around Greenland Island, which may weaken the Atlantic westerly jet stream and lead to amplified wave trains at the exit of the jet, resulting in strengthened anticyclones over EE and NC that favor the occurrences of HWs. The Geophysical Fluid Dynamics Laboratory high‐resolution atmospheric model fails to simulate the EE and NC HWs, due probably to the model's poor representation of the South Asian summer rainfall.
Projected Changes in Summertime Circulation Patterns Imply Increased Drought Risk for the South‐Central United States
Authors: Ryu Jung‐Hee , Hayhoe Katharine , Kang Song‐Lak 
Published: October 2018

AbstractHistorically, extreme hot, dry summers over the South‐Central (SC) United States are dominated by an isolated dome of high pressure centered over the region. Applying self‐organizing map techniques to North American Regional Reanalysis reanalysis and historical and future Coupled Model Intercomparison Project version 5 (CMIP5) simulations, we find that as the world warms, this type of high‐pressure system is likely to become stronger and more frequent—even after removing the effect of surface warming on the expansion of the lower atmosphere. These projected changes appear to be related to self‐reinforcing ocean‐atmosphere interactions in a warming world. Specifically, intensified easterly winds over the Atlantic and Gulf of Mexico drive an increase in the meridional sea surface temperature gradient due to oceanic Ekman transport, which further enhances the ridge of high pressure extending across the SC United States: a dynamical relationship that increases confidence in regional projections of summer drought risk over the SC United States.
Characteristics of Electromagnetic Signals During the Initial Stage of Negative Rocket‐Triggered Lightning
Authors: Fan Yanfeng , Lu Gaopeng , Jiang Rubin , Zhang Hongbo , Li Xiao , Liu Mingyuan , Qie Xiushu , Zheng Dong , Lyu Weitao , Zhang Yang , Zhang Yijun 
Published: October 2018

AbstractWith the measurements in SHandong Triggering Lightning Experiment and Guangdong Comprehensive Observation Experiment on Lightning Discharge in China, we examine the electromagnetic signals associated with the upward positive leaders during the initial stage of negative triggered lightning. The magnetic field (B field) signals measured at close range (<100 m) for both sites can be divided into two categories (i.e., impulsive and ripple pulses) according to the discernibility of separation between individual pulses. The impulsive pulses are well simulated by using the transmission line model, which suggests that these pulses are generated by leader current pulses propagating downward along the steel wire. Because the length of extended leader channel ahead of the wire is not negligible during the stage of ripple pulses, the waveform of impulsive current pulses is changed after traveling through the high impedance leader channel. Taking the filtered current pulse as the input variable, the waveform of ripple pulse can be simulated properly, which indicates that ripple pulses are caused by the attenuation of impulsive current along prolonging leader channel. In addition, the paper analyzes the fast electric field (E field) changes measured at 60‐m range from the launching site during the initial stage by using the transmission line model and shows that the polarity of E field change at a given range is determined by the inception height of upward leader, namely the surface E field change caused by the individual charge transfer of initial upward leader also involves the problem of reverse distance as present for a vertical dipole.
The International Land Model Benchmarking (ILAMB) System: Design, Theory, and Implementation
Authors: Collier Nathan , Hoffman Forrest M. , Lawrence David M. , Keppel‐Aleks Gretchen , Koven Charles D. , Riley William J. , Mu Mingquan , Randerson James T. 
Published: October 2018

AbstractThe increasing complexity of Earth system models has inspired efforts to quantitatively assess model fidelity through rigorous comparison with best available measurements and observational data products. Earth system models exhibit a high degree of spread in predictions of land biogeochemistry, biogeophysics, and hydrology, which are sensitive to forcing from other model components. Based on insights from prior land model evaluation studies and community workshops, the authors developed an open source model benchmarking software package that generates graphical diagnostics and scores model performance in support of the International Land Model Benchmarking (ILAMB) project. Employing a suite of in situ, remote sensing, and reanalysis data sets, the ILAMB package performs comprehensive model assessment across a wide range of land variables and generates a hierarchical set of web pages containing statistical analyses and figures designed to provide the user insights into strengths and weaknesses of multiple models or model versions. Described here is the benchmarking philosophy and mathematical methodology embodied in the most recent implementation of the ILAMB package. Comparison methods unique to a few specific data sets are presented, and guidelines for configuring an ILAMB analysis and interpreting resulting model performance scores are discussed. ILAMB is being adopted by modeling teams and centers during model development and for model intercomparison projects, and community engagement is sought for extending evaluation metrics and adding new observational data sets to the benchmarking framework.
Recommendations for Next‐Generation Ground Magnetic Perturbation Validation
Authors: Welling D. T. , Ngwira C. M. , Opgenoorth H. , Haiducek J. D. , Savani N. P. , Morley S. K. , Cid C. , Weigel R.S. , Weygand J. M. , Woodroffe J. R. , Singer H.J. , Rosenqvist L. , Liemohn M.W. 
Published: October 2018

AbstractData‐model validation of ground magnetic perturbation forecasts, specifically of the time rate of change of surface magnetic field, dB/dt, is a critical task for model development and for mitigation of geomagnetically induced current effects. While a current, community‐accepted standard for dB/dt validation exists (Pulkkinen et al., 2013), it has several limitations that prevent more complete understanding of model capability. This work presents recommendations from the International Forum for Space Weather Capabilities Assessment Ground Magnetic Perturbation Working Team for creating a next‐generation validation suite. Four recommendations are made to address the existing suite: greatly expand the number of ground observatories used, expand the number of events included in the suite from six to eight, generate metrics as a function of magnetic local time, and generate metrics as a function of activity type. For each of these, implementation details are explored. Limitations and future considerations are also discussed.
Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies
Authors: Moriguchi Sho , Takamiya Akihiro , Noda Yoshihiro , Horita Nobuyuki , Wada Masataka , Tsugawa Sakiko , Plitman Eric , Sano Yasunori , Tarumi Ryosuke , ElSalhy Muhammad , Katayama Nariko , Ogyu Kamiyu , Miyazaki Takahiro , Kishimoto Taishiro , Graff-Guerrero Ariel , Meyer Jeffrey H. , Blumberger Daniel M. , Daskalakis Zafiris J. , Mimura Masaru , Nakajima Shinichiro 
Published: October 2018

AbstractAlterations in glutamatergic neurotransmission are implicated in the pathophysiology of depression, and the glutamatergic system represents a treatment target for depression. To summarize the nature of glutamatergic alterations in patients with depression, we conducted a meta-analysis of proton magnetic resonance (1H-MRS) spectroscopy studies examining levels of glutamate. We used the search terms: depress* AND (MRS OR “magnetic resonance spectroscopy”). The search was performed with MEDLINE, Embase, and PsycINFO. The inclusion criteria were 1H-MRS studies comparing levels of glutamate + glutamine (Glx), glutamate, or glutamine between patients with depression and healthy controls. Standardized mean differences (SMD) were calculated to assess group differences in the levels of glutamatergic neurometabolites. Forty-nine studies met the eligibility criteria, which included 1180 patients and 1066 healthy controls. There were significant decreases in Glx within the medial frontal cortex (SMD = −0.38; 95% CI, −0.69 to −0.07) in patients with depression compared with controls. Subanalyses revealed that there was a significant decrease in Glx in the medial frontal cortex in medicated patients with depression (SMD = −0.50; 95% CI, −0.80 to −0.20), but not in unmedicated patients (SMD = −0.27; 95% CI, −0.76 to 0.21) compared with controls. Overall, decreased levels of glutamatergic metabolites in the medial frontal cortex are linked with the pathophysiology of depression. These findings are in line with the hypothesis that depression may be associated with abnormal glutamatergic neurotransmission.
The roles of prostaglandin F2 in regulating the expression of matrix metalloproteinase-12 via an insulin growth factor-2-dependent mechanism in sheared chondrocytes
Authors: Guan Pei-Pei , Ding Wei-Yan , Wang Pu 
Published: October 2018

AbstractOsteoarthritis (OA) was recently identified as being regulated by the induction of cyclooxygenase-2 (COX-2) in response to high fluid shear stress. Although the metabolic products of COX-2, including prostaglandin (PG)E2, 15-deoxy-Δ12,14-PGJ2 (15d-PGJ2), and PGF2α, have been reported to be effective in regulating the occurrence and development of OA by activating matrix metalloproteinases (MMPs), the roles of PGF2α in OA are largely overlooked. Thus, we showed that high fluid shear stress induced the mRNA expression of MMP-12 via cyclic (c)AMP- and PGF2α-dependent signaling pathways. Specifically, we found that high fluid shear stress (20 dyn/cm2) significantly increased the expression of MMP-12 at 6 h ( > fivefold), which then slightly decreased until 48 h ( > threefold). In addition, shear stress enhanced the rapid synthesis of PGE2 and PGF2α, which generated synergistic effects on the expression of MMP-12 via EP2/EP3-, PGF2α receptor (FPR)-, cAMP- and insulin growth factor-2 (IGF-2)-dependent phosphatidylinositide 3-kinase (PI3-K)/protein kinase B (AKT), c-Jun N-terminal kinase (JNK)/c-Jun, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-activating pathways. Prolonged shear stress induced the synthesis of 15d-PGJ2, which is responsible for suppressing the high levels of MMP-12 at 48 h. These in vitro observations were further validated by in vivo experiments to evaluate the mechanisms of MMP-12 upregulation during the onset of OA by high fluid shear stress. By delineating this signaling pathway, our data provide a targeted therapeutic basis for combating OA.
Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens
Authors: Liu Jinxu , Gandhi Pauravi J. , Pavuluri Ratnamala , Shelkar Gajanan P. , Dravid Shashank M. 
Published: October 2018

AbstractCocaine exposure induces plasticity of glutamatergic synapses of medium spiny neurons (MSNs) in the nucleus accumbens (NAc), which has been proposed to contribute to its addictive behavior. The mechanisms underlying cocaine-induced plasticity are not fully understood. The orphan glutamate delta-1 (GluD1) receptor is a member of the ionotropic glutamate receptor family but does not function as a typical ligand-gated ion channel. Instead it serves a synaptogenic function by interacting with presynaptic Neurexin protein. Recent neuroanatomical studies have demonstrated enriched expression of GluD1 in the NAc but its role in reward behavior, MSN function, and drug-induced plasticity remains unknown. Using a combination of constitutive and conditional GluD1 KO models, we evaluated the effect of GluD1 ablation on cocaine-conditioned place preference (CPP) and cocaine-induced structural and functional plasticity. GluD1 KO mice showed higher cocaine CPP. Selective ablation of GluD1 from striatal neurons but not cortico-limbic excitatory neurons reproduced higher CPP. Higher cocaine preference in GluD1 KO correlated with an increase in spine density, greater maturation of dendritic spines, and basally upregulated spine-regulating active cofilin. GluD1 loss did not affect basal excitatory neurotransmission or plasticity but masked the generation of cocaine-induced silent synapses. Finally, loss of GluD1 increased the GluN2B subunit contribution to NMDA receptor currents in MSNs and a partial agonist of GluN2B-containing NMDA receptors normalized the higher active cofilin and cocaine preference in GluD1 KO mice. Together, these findings demonstrate a critical role of GluD1 in controlling susceptibility to cocaine preference and cocaine-induced plasticity by modulating NMDA receptor subunit contribution.
MiR-126 negatively regulates PLK-4 to impact the development of hepatocellular carcinoma via ATR/CHEK1 pathway
Authors: Bao Jie , Yu Yan , Chen Jianan , He Yuting , Chen Xiaolong , Ren Zhigang , Xue Chen , Liu Liwen , Hu Qiuyue , Li Juan , Cui Guangying , Sun Ranran 
Published: October 2018

AbstractEmerging evidence has shown that microRNA-126 (miR-126) is aberrantly downregulated and plays a vital role in carcinogenesis in various cancers, including HCC. However, the underlying biological mechanisms of miR-126 in HCC are still largely unknown. In present study, we found that miR-126 was downregulated both in HCC tissues and cell lines. Low expression level of miR-126 was associated with poor overall survival (OS), late TNM stage and the presence of recurrence. Overexpression of miR-126 significantly decreased cell proliferation, metastasis and promoted apoptosis in vitro. Additional, high miR-126 expression reduced the tumor growth in vivo. Further we discovered that PLK (polo-like kinases)-4, a critical regulator in cell cycle, was a target of miR-126. PLK-4 overexpression could rescue the inhibitory effects of miR-126 on cell proliferation and invasion. Moreover, PLK-4 mRNA and protein levels were significantly upregulated in HCC tissues and positively associated with malignancies and poor OS. Knockdown PLK-4 significantly inhibited cell proliferation, invasion and promoted cell apoptosis in vitro whereas decreased tumor growth in vivo. More importantly, bioinformatics analysis combined with validation experiments in vitro and in vivo showed that activation of the ATR/CHEK1 pathway was involved in the oncogenic functions of PLK4 in HCC. We also validated that PLK4 could directly interact with ATR through CoIP assay. Taken together, we demonstrate that miRNA-126/PLK-4 axis is critical for tumorigenesis and progression of HCC, and the newly identified PLK-4/ATR/CHEK1 pathway may be a potential therapeutic target for HCC treatment.
CIRBP is a novel oncogene in human bladder cancer inducing expression of HIF-1α
Authors: Lu Mengxin , Ge Qiangqiang , Wang Gang , Luo Yongwen , Wang Xiaolong , Jiang Wei , Liu Xuefeng , Wu Chin-Lee , Xiao Yu , Wang Xinghuan 
Published: October 2018

AbstractCold-inducible RNA binding protein (CIRBP) has been reported to be associated with distinct tumorigenesis. In this study, we investigated the role of CIRBP in human bladder cancer (BCa), indicating that CIRBP is overexpressed in BCa tissues and cell lines to promote proliferation and migration. Moreover, CIRBP could induce expression of HIF-1α via binding to the 3′-UTR of its mRNA to increase the mRNA stability in BCa cells. Furthermore, we demonstrated that PTGIS is a HIF-1α targeted gene, a major regulator in hypoxic cancer progression by activating transcription of various oncogenes. Our results also suggested that overexpression of HIF-1α may suppress the expression of PTGIS in BCa cells, by binding to HRE sequence at the promoter region of PTGIS. In addition, we found a strongly downregulation of PTGIS in BCa tissue and transcriptionally inhibited by HIF-1α in BCa cells, which could be triggered by its DNA methylation. Further result suggested that knockdown of CIRBP could promote the expression of PTGIS, meanwhile knockdown of PTGIS could partially rescue CIRBP-deficiency induced inhibition of migration and proliferation in BCa cells. Taken together, our study indicated that CIRBP could be a novel oncogene in human bladder cancer inducing transcription of HIF-1α, which could inhibit expression of methylated PTGIS.
A discrete organoplatinum(II) metallacage as a multimodality theranostic platform for cancer photochemotherapy
Authors: Yu Guocan , Yu Shan , Saha Manik Lal , Zhou Jiong , Cook Timothy R. , Yung Bryant C. , Chen Jin , Mao Zhengwei , Zhang Fuwu , Zhou Zijian , Liu Yijing , Shao Li , Wang Sheng , Gao Changyou , Huang Feihe , Stang Peter J. , Chen Xiaoyuan 
Published: October 2018

AbstractPhotodynamic therapy is an effective alternative to traditional treatments due to its minimally invasive nature, negligible systemic toxicity, fewer side effects, and avoidance of drug resistance. However, it is still challenging to design photosensitizers with high singlet oxygen (1O2) quantum yields (QY) due to severe aggregation of the hydrophobic photosensitizers. Herein, we developed a discrete organoplatinum(II) metallacage using therapeutic cis-(PEt3)2Pt(OTf)2 as the building block to improve the 1O2 QY, thus achieving synergistic anticancer efficacy. The metallacage-loaded nanoparticles (MNPs) with tri-modality imaging capability allow precise diagnosis of tumor and real-time monitoring the delivery, biodistribution, and excretion of the MNPs. MNPs exhibited excellent anti-metastatic effect and superior anti-tumor performance against U87MG, drug resistant A2780CIS, and orthotopic tumor models, ablating the tumors without recurrence after a single treatment. Gene chip analyses confirmed the contribution of different therapeutic modalities to the tumor abrogation. This supramolecular platform holds potential in precise cancer theranostics.
Emergence of superconductivity in the cuprates via a universal percolation process
Authors: Pelc Damjan , Vučković Marija , Grbić Mihael S. , Požek Miroslav , Yu Guichuan , Sasagawa Takao , Greven Martin , Barišić Neven 
Published: October 2018

AbstractA pivotal step toward understanding unconventional superconductors would be to decipher how superconductivity emerges from the unusual normal state. In the cuprates, traces of superconducting pairing appear above the macroscopic transition temperature Tc, yet extensive investigation has led to disparate conclusions. The main difficulty has been to separate superconducting contributions from complex normal-state behaviour. Here we avoid this problem by measuring nonlinear conductivity, an observable that is zero in the normal state. We uncover for several representative cuprates that the nonlinear conductivity vanishes exponentially above Tc, both with temperature and magnetic field, and exhibits temperature-scaling characterized by a universal scale Ξ0. Attempts to model the response with standard Ginzburg-Landau theory are systematically unsuccessful. Instead, our findings are captured by a simple percolation model that also explains other properties of the cuprates. We thus resolve a long-standing conundrum by showing that the superconducting precursor in the cuprates is strongly affected by intrinsic inhomogeneity.
DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage
Authors: Xiao Xiao , Liang Jiankai , Huang Chunlong , Li Kai , Xing Fan , Zhu Wenbo , Lin Ziqing , Xu Wencang , Wu Guangen , Zhang Jifu , Lin Xi , Tan Yaqian , Cai Jing , Hu Jun , Chen Xueqin , Huang Youwei , Qin Zixi , Qiu Pengxin , Su Xingwen , Chen Lijun , Lin Yuan , Zhang Haipeng , Yan Guangmei 
Published: October 2018

AbstractOncolytic virotherapy is a promising therapeutic strategy that uses replication-competent viruses to selectively destroy malignancies. However, the therapeutic effect of certain oncolytic viruses (OVs) varies among cancer patients. Thus, it is necessary to overcome resistance to OVs through rationally designed combination strategies. Here, through an anticancer drug screening, we show that DNA-dependent protein kinase (DNA-PK) inhibition sensitizes cancer cells to OV M1 and improves therapeutic effects in refractory cancer models in vivo and in patient tumour samples. Infection of M1 virus triggers the transcription of interferons (IFNs) and the activation of the antiviral response, which can be abolished by pretreatment of DNA-PK inhibitor (DNA-PKI), resulting in selectively enhanced replication of OV M1 within malignancies. Furthermore, DNA-PK inhibition promotes the DNA damage response induced by M1 virus, leading to increased tumour cell apoptosis. Together, our study identifies the combination of DNA-PKI and OV M1 as a potential treatment for cancers.
mRNAs and lncRNAs intrinsically form secondary structures with short end-to-end distances
Authors: Lai Wan-Jung C. , Kayedkhordeh Mohammad , Cornell Erica V. , Farah Elie , Bellaousov Stanislav , Rietmeijer Robert , Salsi Enea , Mathews David H. , Ermolenko Dmitri N. 
Published: October 2018

AbstractThe 5′ and 3′ termini of RNA play important roles in many cellular processes. Using Förster resonance energy transfer (FRET), we show that mRNAs and lncRNAs have an intrinsic propensity to fold in the absence of proteins into structures in which the 5′ end and 3′ end are ≤7 nm apart irrespective of mRNA length. Computational estimates suggest that the inherent proximity of the ends is a universal property of most mRNA and lncRNA sequences. Only guanosine-depleted RNA sequences with low sequence complexity are unstructured and exhibit end-to-end distances expected for the random coil conformation of RNA. While the biological implications remain to be explored, short end-to-end distances could facilitate the binding of protein factors that regulate translation initiation by bridging mRNA 5′ and 3′ ends. Furthermore, our studies provide the basis for measuring, computing and manipulating end-to-end distances and secondary structure in RNA in research and biotechnology.
Narrow bounds for the quantum capacity of thermal attenuators
Authors: Rosati Matteo , Mari Andrea , Giovannetti Vittorio 
Published: October 2018

AbstractThermal attenuator channels model the decoherence of quantum systems interacting with a thermal bath, e.g., a two-level system subject to thermal noise and an electromagnetic signal traveling through a fiber or in free-space. Hence determining the quantum capacity of these channels is an outstanding open problem for quantum computation and communication. Here we derive several upper bounds on the quantum capacity of qubit and bosonic thermal attenuators. We introduce an extended version of such channels which is degradable and hence has a single-letter quantum capacity, bounding that of the original thermal attenuators. Another bound for bosonic attenuators is given by the bottleneck inequality applied to a particular channel decomposition. With respect to previously known bounds we report better results in a broad range of attenuation and noise: we can now approximate the quantum capacity up to a negligible uncertainty for most practical applications, e.g., for low thermal noise.