bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENDAMPINGAN PEMBUATAN PRODUK BERBAHAN DASAR JAGUNG
Authors: Tahengo Sulista , Rosilawati Ratmi 
Published: June 2019

Tujuan utama pelaksanaan kegiatan ini adalah untuk meningkatkan partisipasi masyarakat desa Urundaka di Uetoli Kecamatan Ampana Tete Kabupaten Tojo Una-una dalam mengelola sumber daya alam yang tersedia untuk pendampingan pembuatan produk berbahan dasar Jagung. Metode pelaksanaan yang dilakukan untuk mewujudkan luaran kegiatan ini yaitu metode partisipasi,dimana seluruh kegiatan dilaksanakan bersama masyarakat. Adapun pelaksanaan kegiatan meliputi sosialisasi mengenai pendampingan pembuatan produk berbahan dasar jagung.Kata kunci : Produk, Jagung
The Effect of Active Gambir (Uncaria gambir) Fraction on TNF-Î± Protein Expression and Lesion Size in Rats Induced Gastritis
Authors: Suasti Ni Wayan Lisa , Oktafitria Lunsi , Aidia Ellya , Dhani Rahmad 
Published: June 2019

Background: Gambir (Uncaria gambir) is empirically used to treat abdominal pain and vomittus caused by gastritis because of its anti-inflammatory effects, especially flavonoid. This study aims to determine the effect of active gambir fraction on TNF-Î± protein expression and wound size in white rats gastritis model.
Methods: The research method used experimental study design in vivo with post test with control group design. Rats were divided randomly in 11 groups and were induced to be gastritis for 1 day. Group 1 (negative control) was given aquadest of 5 mL, group 2 (positive control) was administered ranitidine 10 mg/kgBW, groups 3, 4, and 5 were given n-hexane fraction, groups 6, 7 and 8 were given a water fraction, and groups of 9, 10, and 11 were given ethyl fractions with each group receives dose of 20, 40, and 80 mg/kgBW and all groups were treated for 3 days. Rats were dissected on 5th day for examination of gastric mucosal lesion size and performed ELISA expression of TNF-Î± expression of gastric mucosal tissue. The results of this study were assayed by SPSS 18.
Results: The result of the research using Kruskal-Wallis test showed that there were significant differences (p <0.05) of the lesions size between the sample groups where control positive, ethyl fraction 20, 40, 80 mg/kgBW, and water fraction 20, 40 mg/kgBB had the gastric â€‹â€‹mucosal lesion size differed significantly with the negative control group, while the TNF-Î± protein expression test using Kruskal-Wallis showed that there was a significant difference (p <0.05) TNF-Î± levels of all groups against the negative control.
Conclusion: Active gambir fraction had a potention to reduce size of mucose gaster lesion and reduce expression of TNF-Î± protein.

Keywords: Gambir â€“ TNF-Î± â€“ antiinflamatory â€“ gastiritis
Soil Transmitted Helminths (STH) Infection Relatedâ€¨Body Mass Index in Elementary School Students, Sukawinatan Landfill, Palembang City
Authors: Ramayanti Indri , Makmun Asmarani 
Published: June 2019

ABSTRACT
Introduction
The age of Primary School Children are the group most often affected by worm infections with a prevalence of more than 60%. Worm infection can cause a decrease in health conditions, Body Mass Index (BMI), intelligence and productivity of sufferers so that economically causes a lot of losses and decreases in the quality of human resources.
Aims of Study
The purpose of this study was to determine the relationship of infection with Soil Transmitted Helminths (STH) with the Body Mass Index (BMI) in the children of Elementary School ( SDN 188), Sukawinatan Landfill, Sukarame District, Palembang City.
Methods
This research is an analytic observational study with a cross-sectional approach. The population consisted of all children of SDN 188 Sukarame Subdistrict, Palembang City, 109 people who were selected by consecutive sampling. Examination of helminthiasis infection was obtained by taking faecal samples on the subject and then examined by laboratory with Kato-Katz method and Body Mass Index (BMI) through anthropomometric measurements of height and weight. The analysis carried out was univariate descriptively and bivariately by Chi-square test.
Results
There were found 27 (24.8%) children who were positive for helminthiasis and from the results of the bivariate test there was no correlation between STH infection and BMI (p> 0.05).
Conclusion
there was no significant relationship between infection with Soil Transmitted Helminths (STH) and the Body Mass Index (BMI) of primary school age children around the Sukawinatan landfill in Palembang.
Keywords: STH Infection, Body Mass Indeks, Landfiil Area
The Recommended Aerobic Gymnastics Has Better Effects on Improving Cognitive and Motoric Ability in Children
Authors: Kadir Minerva Riani , Irfanuddin Irfanuddin , Fediani Yunita , Santoso Budi , Dewi Masayu Rita 
Published: June 2019

Abstract

Background Cognitive and motoric ability has important role in childrenâ€™s development, whereas exercise has benefit effects on those abilities. Knowledge materials mostly have dominant role in primary school curriculum. Physical exercise lesson is only complementary lesson without a target to improve childrenâ€™s cognitive ability. We conducted a study to give evidence that 3x/week structured exercise program has better effect compared to 1 x/week exercise on cognitive and motoric skill ability in children. Materials and methods Children aged 6-8 years old were divided into treatment (n=34) and control group (n=33). Treatment group were performing fun aerobic gymnastics guided by trained instructor, 45 minutes each, 3 times a week for 8 weeks with intensity target. Control group were also performing the same gymnastic activity for only once a week with no target. Cognitive and motoric ability were assessed before and after intervention. Results A recommended regular exercise has better effect on executive function, reaction speed, coordination, flexibility and agility, compared to control. There were no differences on memory and balance ability. Both groups have shown better result for all indicators after exercise. Exercise in both groups has positive effect on cognitive and motoric ability, but a recommended 3 x/week regular exercise has better effects compared to 1 x/week exercise. Conclusions School program should give more portions for exercise activity in their curriculum.
Keywords: Gymnastics exercise, cognitive ability, motoric ability
The Risk Factors of Anorectal Malformation Patients Mortality in Palembang
Authors: Bima Muhammad , Dastamuar Shalita , Hidayat Rachmat 
Published: June 2019

Anorectal malformations are serious anal and rectal disorders ranging from stenosis to anorectal agenesis. The incidence of mortality in cases of anorectal malformations is influenced by many factors, including the type of anorectal malformation, associated congenital anomalies, sepsis, and prematurity as investigated in this study. The aim of this study was to identify the risk factor of mortality on anorectal malformation patients. This study is an observational analytic study with cross sectional study design. Secondary data collection was obtained from eighty-two medical records of anorectal malformation patients in Dr. Mohammad Hoesin Hospital Palembang from January 2015 to June 2017 that meets the inclusion criteria. From eighty-two cases of anorectal malformations found nineteen cases of mortality (23.2%). There were four risk factors identified, anorectal malformation type, associated congenital anomalies, sepsis, and prematurity. Two risk factors found significantly affect the mortality on anorectal malformation patients, anorectal malformation type (p value = 0.036) and sepsis (p value = 0.049) from four risk factors studied. Type of anorectal malformation and sepsis have a significant effect on the mortality of patients with anorectal malformations, but there is no effect on the mortality of the patients with assciated congenital anomalies and prematurity.

Keywords: Anorectal malformation, congenital abnormalities, sepsis, prematurity
N-Acetyl-Glucosamidase as Biomarker for Acute Kidney Injury
Authors: Rizki Aulia Annisa , Zulkifli Zulkifli , Haloho Agustina Br , Hafy Zen 
Published: June 2019

Background : The estimated inciÂ­dence of Acute Kidney Injury (AKI) is two to three cases per 1,000 patients. Seven percent of hospitalized patients and about two-thirds of patients in intensive care units develop acute kidney injury and the mortalÂ­ity rates range between 25 and 80 percent. Disruption in epithelial brush border of proximal tubular cell causes N-Acetyl-Î²-D-Glucosaminidase (NAG) to be released to the urine and the amount of enzyme could be directly correlated with tubular disruption.
Objective : The aims of this research is to determine the sensitivity and specificity of NAG urine examination as an early biomarker for acute kidney injury.
Methods : Thereâ€™s 66 subjects who met the inclusion criteria. All the subject were checked for the NAG urine level with Cloud Clone kit and creatinine serum were also checked 48 hours after admission.
Results : The results showed in the cut-off point of 7.98 Ng/mL, urine NAG has a sensitivity of 68.6% and specificity 77.4%, positive predictive value 77.42%, negative predictive value 68.57 % and accuracy of 72.73%
Conclusions : The result shows that urine NAG examination is more sensitive and specific as an early biomarker for Acute Kidney Injury compared to creatinine serum.
Key words : Acute Kidney Injury, N-Acetyl-Î²-D-Glucosaminidase , sensitivity, spesificity
Sensitivity and Spesificity of Interleukin 18 as Biomarker for Acute Kidney Injury
Authors: Gunawan Febri Jaya , Irwanto F Heru , Miarta Andi , Theodorus Theodorus 
Published: June 2019

Background : Incidence of AKI in intensive care unit patients reach 60-70%, and the mortality rate is about 60%. IL-18 is a pro-inflammatory cytokine which increased in endogenous inflammation process. Studies in human showed that IL-18 concentration increased prior to AKI.
Objective : The aims of this research is to determine the sensitivity and specificity of Interleukin-18 urine examination as an early biomarker for acute kidney injury.
Methods : Thereâ€™re total of 66 subjects who met the inclusion criteria. All the subject were checked for the IL-18 urine level with Cloud Clone kit and creatinine serum were also checked 48 hours after admission.
Results :The results showed in the cut-off point of 411.25 Pg/mL , urine IL-18 has a sensitivity of 54.3 % and specificity 83.9%, positive predictive value 79.17%, negative predictive value 61.9% and accuracy of 68.18%
Conclusions : Our result suggest that IL-18 urine holds a promise as an early biomarker of AKI and more sensitive and specific as an early biomarker for AKI compared to creatinine serum.
Key words : Acute Kidney Injury, Interleukin-18, sensitivity, spesificity
Identification of IL-10 Gene Polymorphisms in Leprosy
Authors: Oktariana Desi , Susilawati Susilawati , Prasasti Gita Dwi 
Published: June 2019

Background: Leprosy is a chronic disease caused by an infection of Mycobacterium leprae, which affects skin and nerve lesions, which can result in disability. The prevalence of leprosy continues to increase, especially in Indonesia, which is one of the endemic areas of leprosy. The unique immune response of each individual not only determines the susceptibility of individuals to leprosy, but also determines the type of leprosy that will manifest. One of the immune responses that plays an important role in the pathogenesis of leprosy is interleukin-10 (IL-10). Increased regulation of IL-10 can have an effect on decreasing macrophage activity in killing bacteria. Production of IL-10 is regulated by genes that encode the cytokine. Gen IL-10 is located on chromosome 1q32. Polymorphism in this gene can cause variations in the function of IL-10 protein, which can then influence the process of microbial elimination in the development of leprosy.Objective: This study aimed to identify IL-10 -819 C / T gene polymorphisms which were cut with the MslI enzyme in lepers.Method: This study is a laboratory study, which is also an observational descriptive study with a cross sectional study approach to 40 subjects with leprosy. Identification of IL-10 -819 C / T gene polymorphism was carried out by PCR amplification and RFLP (restriction fragment length polymorphism) technique using the MslI enzyme.
Results: Distribution of TT, CT, and CC genotypes in the study subjects were 0 (0%), 14 (35%), and 26 (65%). Based on age, the distribution was 0 (0%), 6 (15%), 19 (47.5%) for those under 50 years old, and 0 (0%), 8 (20%), 7 (17.5 %) for those over 50 years old. Based on gender, the distribution is 0 (0%), 5 (12.5%), 16 (40%) in men, and 0 (0%), 9 (22.5%), 10 (25%) in women. Based on the classification of diseases, the distribution was 0 (0%), 3 (7.5%), 7 (17.5%) for papalacillary, and 0 (0%), 11 (27.5%), 19 (47.5 %) for multibasilers.
Conclusion: More wild type genotypes are found in lepers (65%).
Keywords: leprosy, polymorphism, IL-10 gene
The Efficacy of Cinnamomum burmanii Extract on the Protection of Neuronal Cell Death in Haloperidol Induced Male Wistar Rats
Authors: Parisa Nita , Kamaluddin MT , Theodorus Theodorus 
Published: June 2019

Background
Haloperidol is categorized as the first class antipsychotic drug. Long-term use of haloperidol may convey to increased Reactive Oxygen Species (ROS) that will yield oxidative damage which further leads to cell death. Several studies had identified the effects of cinnamon extract on cell death. This study aimed to determine the efficacy of cinnamon extract (Cinnamomum burmanii) on the protection of neuronal cell death in haloperidol-induced male Wistar white rats.
Methods
This study was experimental with pre and post-test design. Thirty male Wistar rats were divided into 5 groups, induced with haloperidol and followed by treatment. Caspase-3 and dopamine were assayed by ELISA sandwich method using ELISA kit. Mean difference of caspase expression and dopamine levels before and after induction were shown (p<0.05).
Results
There were mean differences of caspase-3 expression level in the positive control group, cinnamon extract of 100 and 200mg/kgBW before and after treatment (p<0.05). Whereas for dopamine levels, there were mean differences in positive control group, cinnamon extract of 50, 100 and 200mg/kgBW before and after treatment (p<0.05). With Post Hoc test, it was found that there were no mean differences of caspase-3 expression level between positive group with cinnamon extract group of 100 and 200mg/kgBW (p>0,05) and there were also no mean differences of positive group dopamine level with group of cinnamon extract of 100 and 200mg/kgBW (p>0.05).
Conclussion
Cinnamomum burmanii extract at dose of 100 and 200mg/kgBW were effective in the protection against neuronal cell death in haloperidol induced male Wistar white rats.
The Efficacy of Combination Extract Andrographis peniculata and Syzygium polyanthum on Glucose Uptake in Skletal Muscle in Diabetic Rats
Authors: Karim Fatmawati , Panserga Ester Gonzales , Saleh Mgs Irsan 
Published: June 2019

Insulin resistance is impaired insulin signaling cascade in target cells to respond normal or elevated circulating insulin to the final cellular effect, such as translocation of vesicles containing GLUT4 glucose transporters, which is the major mediator of glucose removal from the circulation and a key regulator of whole-body glucose homeostasis. Among the several plants, Andrographis peniculata (sambiloto) and Syzygium polyanthum (Daun salam). In the present study, a combination was made, Andrographis peniculata (sambiloto) and Syzygium polyanthum (Daun salam), and to determine the effects of combination on tretament insulin resistance. Male Wistar rats (weight, 200-300 g) were randomized into five groups (6 rats/group). Group 1: negative group. Group 2: positive group (metformin 63 mg/kgBW ). Group 3,4 and 5: treatment with extract combination, each group 250 mg/kgBW, 500 mg/kgBW and 1000 mg/kgBW. Rats were induced by high fat diet-glucocorticoid for insulin resistance. Insulin and GLUT-4 were assayed by ELISA. Treatment with extract combination (250, 500 and 1000 mg/kgBW) and metformin for 2 weeks showed a sigificant decrease in fasting plasma insulin compare with the negative control rats with a reduction of 11,2%, 33,6%, 20% and 19,4%, respectively. Two weeks treatment either extract combination or metformin in diabetic rats, significantly increased GLUT 4 level (p<0,05) with a percentage increase of 6,68%, 15,21%, 12,76% and 1,77%.
Association of Sociodemographic, Knowledge, Attitude and Practice with Pediculosis Capitis
Authors: Amelia Linda , Anwar Chairil , Wardiansah Wardiansah 
Published: June 2019

Introduction : Pediculosis capitis is an infection of scalp and hair in humans caused by infestation of Pediculus humanus capitis and usually extends rapidly in a dense environment such as boarding schools. Aim of study : The aim of this study was to determine the association of studentsâ€™ sociodemographic, knowledge, attitude and practice with pediculosis capitis in Pondok Pesantren Tahfidzil Qur'an Yayasan Tijarotal Lan Tabur Palembang.
Methods : This research was an analytical observational study with a cross sectional design conducted on November 2018. There were 117 samples that had the inclusion criteria and hadnâ€™t exclusion criteria. Data collected from anamnesis, questionnaires and hair examinations of respondents. The results were analyzed using Chi-Square and Logistic Regression.
Results : Out of 117 students, 57 students (48.7%) has been found positive pediculosis capitis. Statistical test showed that age (p<0.001), gender (p<0.001), education level (p<0.001), knowledge (p=0.035), attitude (p=0.003) and practice (p =0.043) have significant association to the prevalence of pediculosis capitis. However, there was no significant association between father's education (p=1.000), mother's education (p=0.743), father's job (p=0.314), mother's job (p=1.000) and parents' income (p=1.000) to the prevalence of pediculosis capitis. The results of Multiple Logistic Regression analysis showed that gender, knowledge and practice were the most influential factors to the prevalence of pediculosis capitis (p<0.05) with the probability of 96.7%.
Conclusion : There was a significant association between age, gender, education level, knowledge, attitude and practice to the prevalence of pediculosis capitis, and the most dominant variables were gender, knowledge and practice.
Sleep and Bone Density: A Study on Postmenopausal Indonesian Women
Authors: Irmayati Shafira , Reagan Muhammad , Legiran Legiran 
Published: June 2019

Background: Low bone density has been known as one of the factors that increased fracture risk. Aging, estrogen deficiency, low BMI, and inadequate calcium intake are known factors that contribute to decreased bone density. Other than the known factors, some research show that sleep duration can also lower bone density. Sleep affects bone density in a way that it causes increased level of cortisol, proinflammatory cytokine, and decreased in physical activity.
Method: This study is an observational analytic study with cross-sectional design. It is conducted on menopausal patients that has been examined with bone mineral densitometry at Poliklinik Reumatologi Penyakit Dalam RSUP Dr. Mohammad Hoesin Palembang in November 2017 to Oktober 2018. Samples are collected using total sampling technique.
Results: From 93 subjects that participated in this study, 20,4% of them had osteopenia, and 51,6% had osteoporosis. Patients with low bone density, mainly slept for 6 to 8 hours at night per day, 30 minutes of nap per day, and has a total sleep duration for less than 8 hours each day. This study shows no significant association between night-time sleep, daytime napping, and total sleep duration with bone density (p value = 0,168, p value = 0,831, p value = 0,984). Analysis on other risk factors show significant association between body mass index and low bone density (p value = 0,002).
Conclusion: There are no significant association between sleep duration and bone density in menopausal patients at Poliklinik Reumatologi RSUP Dr. Mohammad Hoesin Palembang.
The Relationships between Neutrophil/Lymphocyte Ratio and Child-Turcotte-Pugh Classification in Assessing Severity of Liver Cirrhosis
Authors: Griselda Griselda , Rahadiyanto Kemas Ya'Kub , Hidayat Rachmat 
Published: June 2019

Background
Liver cirrhosis is a disease with high morbidity and mortality in Indonesia. The Child-Turcotte-Pugh classification is a noninvasive parameter to assess severity of liver cirrhosis. Meanwhile, the neutrophil/lymphocyte ratio can reflect person's immunity to liver cirrhosis. This study was conducted to determine the agreement between neutrophil/lymphocyte ratio and Child-Turcotte-Pugh classification in assessing severity of liver cirrhosis.
Methods
Analytical observational study with Cohenâ€™s Kappa agreement test was conducted in 86 liver cirrhosis patients. Data was retrieved by observing the medical records. Neutrophil count, lymphocyte count, hepatic encephalopathy, ascites, albumin, bilirubin, and INR were all recorded. Documented variables were analyzed by the Cohenâ€™s Kappa agreement test.
Results
In Cohenâ€™s Kappa agreement test, there was moderate agreement between neutrophil/lymphocyte ratio and Child-Turcotte-Pugh classification in all samples (Îº = 0.591 and p <0.001). Agreement between neutrophil/lymphocyte ratio and Child-Turcotte-Pugh classification based on age and gender was found to be Îº = 0.777 at age â‰¤45 years, Îº = 0.532 at age >45 years, Îº = 0.682 in male, and Îº = 0.445 in female (p <0.001). The highest agreement is the substantial agreement between neutrophil/lymphocyte ratio and Child-Turcotte-Pugh classification obtained at age â‰¤45 years (Îº = 0.777 and p <0.001) and male (Îº = 0.682 and p <0.001).
Conclusion
There is moderate agreement between neutrophil/lymphocyte ratio and Child-Turcotte-Pugh classification in assessing severity of liver cirrhosis. Substantial agreement obtained at age â‰¤45 years and male gender.

Keywords: Neutrophil/Lymphocyte Ratio, Child-Turcotte-Pugh, Liver Cirrhosis
Association of Stress Level with Menstrual Disturbance Among Female Students in Medical Faculty Sriwijaya University
Authors: Taufiq Fildzah Hashifah , Hasnawi Herry , Hidayat Rachmat 
Published: June 2019

Association Of Stress Level With Menstrual Cycle Disturbance Among Female Students In Medical Faculty Of Sriwijaya University. Menstruation occurs regularly every month will form a menstrual cycle. Normal menstrual cycles in women range from 21-35 days. However, the menstrual cycle is not always normal, many women experience menstrual disturbance. Menstrual cycle disturbance are caused by several factors, which is stress. This study aims to analyze the association of stress level with menstrual cycle disturbance among female students in Medical Faculty of Sriwijaya University. This study is analytical cross-sectional study with primary data from menstrual cycle, stress ISMA, personality type DSM V questionnaires.. In this study, 503 samples are fulfilled inclusion criteria. Among 503 subjects, 59 (11.7%) female students experienced polymenorrhea, 391 (77.7%) female students had normal menstrual cycles, 53 (10.6%) female students experienced olygomenorrhea. Chi Square test showed that there was an association between stress level and menstrual cycle disturbance. There is a significant association between between stress level and menstrual cycle disturbance among female students in Medical Faculty of Sriwijaya University.
Keywords: Stress level, Menstrual cycle disturbance.