bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Polymorphisms of FAM13A, PHLDB1, and CYP24A1 in Breast Cancer Risk
Authors: Wei Ying , Wang Xiaolin , Zhang Zhe , Xie Mingrui , Li Yuyao , Cao Hongxin , Zhao Xinhan 
Published: June 2019

Background:
Single-nucleotide polymorphisms (SNPs) are important
indicators of susceptibility to breast cancer.

Objective:
To assess the associations between SNPs in the FAM13A, PHLDB1, and
CYP24A1 gene and breast cancer risk in the Chinese Han population.

Methods:
We performed a case-control study including 379 female breast cancer
patients and 407 female healthy controls. The three SNPs were genotyped using Agena
MassARRAY platform. The χ2 test was used to compare alleles and genotypes
frequencies of polymorphisms between case and control groups. Genetic models
analyses to assess the associations between SNPs and breast cancer risk by computing
odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression.
RegulomeDB and HaploReg databases were used to calculate possible functional
effects of polymorphisms.

Results:
Overall analysis results showed that rs4809957 was associated with an
increased risk of breast cancer (allele A: OR = 1.27, 95% CI: 1.03-1.55, p = 0.024; AA
vs. GG: OR = 1.80, 95% CI: 1.15–2.82, p = 0.010; recessive model: OR = 1.70, 95% CI:
1.12–2.58, p = 0.012); and rs1059122 was found to be associated with a reduced breast
cancer risk in the recessive model (OR = 0.71, 95% CI: 0.51–0.98, p = 0.039).
Stratification analysis found significant associations between the three SNPs
(rs1059122, rs17748, and rs4809957) and breast cancer risk.

Conclusion:
Our results suggested that rs1059122 (FAM13A), rs17748 (PHLDB1), and
rs4809957 (CYP24A1) might contribute to breast cancer susceptibility in the Chinese
Han population. Future studies with large samples are required to confirm our findings,
as well as functional studies are needed to explore their function in the breast cancer
development.
Virtual Screening of Novel Hybrid Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Exploring Multiple Targeted Cancer Therapy by an In Silico Approach
Authors: Shah Ashish P. , Patel Chhagan N. 
Published: June 2019

Background:
Dual-targeting/Multi-targeting of oncoproteins by a single drug molecule
represents an efficient, logical and alternative approach to drug combinations. In silico methods
are useful tool for the search and design of selective multi-target agents.

Objective:
The objective of the present study was to design new hybrid compounds by linking the
main structural unit of the NSAIDs with the benzothiazole and thiadiazole ring and to discover
new hybrid NSAIDs as multi targeted anticancer agents through in silico approach.

Method:
Structure-based virtual screening was performed by applying ADMET filtration and
Glide docking using Virtual screening Workflow. The docking studies were performed on three
different types of receptors TNF-α, COX-II and protein kinase. Bioactivity prediction of screened
compounds were done using Molinspiration online software tool.

Results:
Out of 54 designed compounds eighteen were screened on the basis of binding affinity on various receptors and ADMET filtration. Bioactivity prediction reveals that screened compounds may act through kinase inhibition or enzyme inhibition. Compounds 2sa, 5sa, 6sa and 7sa shows higher binding affinity with all three receptors.

Conclusion:
The study concluded that compound 2sa, 5sa, 6sa, and 7sa could be further explored
for multiple targeted cancer therapy.
Diagnostic Accuracy of Ultrasound for the Evaluation of Lateral Compartment Lymph Nodes in Papillary Thyroid Carcinoma
Authors: Colakoglu Bulent , Alis Deniz , Seymen Hulya 
Published: June 2019

Aims:
To evaluate the diagnostic accuracy of ultrasound (US) assessing the lateral compartment
lymph node metastasis in patients with primary papillary thyroid carcinoma (PTC), and to
demonstrate the incidence and patterns of the lateral lymph node metastasis.

Methods:
We retrospectively reviewed 198 patients with primary PTC who underwent thyroidectomy
in addition to modified lateral neck dissections (MLND) involving level II to level V due to
clinically positive lateral neck disease. A skilled and experienced single operator performed all US
examinations. Surgical pathology results were accepted as the reference method and sensitivity,
specificity, and diagnostic accuracy of US in detecting metastatic lymph nodes established using
level-by-level analysis.

Results:
In the study cohort, 10.1% of the patients had lateral compartment lymph node metastases
without any central compartment involvement. For the lateral compartment, 48.5% had level II,
74.7% had level III, 64.6% had level IV, and 29.3% of the patients had level V metastasis. None of
the patients had isolated level V metastasis. The sensitivity, specificity, and diagnostic accuracy of
US in identifying lateral lymph compartment metastasis ranged from 87% to 91.4%, 92% to 98.6%
92.4% to 96%, respectively. However, the sensitivity (74.7%) and diagnostic accuracy (76.2%) of
US significantly decreased for the central compartment while specificity (90%) remained similar.

Conclusion:
US performed by a skilled operator has an excellent diagnostic accuracy for the
evaluation of lateral cervical lymph nodes in primary PTC; thus, might enable precise tailoring of
the management strategies. Moreover, the high incidence of level V involvement favors MLND
over selective approaches.
Primary Thalamic Haemorrhage – Clinical Profile and Prognostic Predictors from a Series of 117 Cases
Authors: Menon Girish , Hegde Ajay , Kongwad Lakshman I , Omkarappa Sandesh 
Published: June 2019

Background:
Studies on isolated primary thalamic hematomas are limited. This study analyses 117 patients with primary thalamic hematomas and attempts to identify the various prognostic factors influencing the outcome.

Materials and Methods:

A retrospective analysis of the case records was carried out to analyse the following prognostic parameters - GCS on admission, comorbidities like systemic hypertension and diabetes mellitus, side and site of hematoma, volume of the clot, presence of intraventricular haemorrhage (IVH), development of hydrocephalus, and the role of surgical intervention. A Chi-square test was used to compare categorical variables, and Student t-test and Mann Whitney test were applied to calculate the P-value for continuous variables for univariate statistics. Binary Logistic regression was used for multivariate analysis.

Results and Discussion:

This study group comprised 67 men and 50 women with a mean age of 62.05±11.71years. The mean GCS on admission in the study group was 11.56±3.28. The mean clot volume was 13±9.5ml and majority (89.74%) of the patients had clots with a volume of less than 20 ml. An intraventricular extension was noted in 98 patients. Craniotomy and surgical evacuation were performed in only two patients while external ventricular drainage with urokinase instillation was performed in 23 patients. Of the 117 patients, 3 had anterior thalamic clots, 19 had posterior thalamic clots, 13 had medial clots, 53 had lateral thalamic bleeds and 29 had global clots. The overall three-month mortality with thalamic bleeds was 28.2%. At the end of three months, 59 patients (50.42%) had a favourable outcome (mRS < 4). On univariate analysis, male sex, dominant side bleed, preoperative GCS of less than 8 (p < 0.001), presence of hydrocephalus (p< 0.004) and a need for EVD (p<0.012) were found to be significantly associated with mortality and poor outcome. Similarly, clot volume less than 20 ml, right-sided bleed and surgical evacuation were associated with a favourable outcome (p < 0.001). On multiple logistic regression, age, volume of hematoma and GCS on admission were predictors for mortality and volume of hematoma was a significant predictor of poor outcome.

Conclusion:
Thalamic hematomas include a spectrum of clots of varying dimensions at different locations and the outcomes need not be uniformly poor. Isolated thalamic hemorrhages are generally small in volume preferentially located in the lateral thalamus. Patients with right-sided bleeds and small clot volume perform well. Male sex, poor GCS on admission, clot volume above 20 ml, intraventricular extension and a need for external ventricular drainage adversely influence the outcome.
The Effect of Minor Doses of Olanzapine-Solid Lipid Nanoparticles on an Animal Model of Schizophrenia (Neurochemical and Behavioral Study) and the Side Effect
Authors: Abd-Elrazek Areeg , Elnawawy Tayseer 
Published: June 2019

Background and Objective:Olanzapine (OLZ) is an atypical psychotic agent; the poor bioavailability of olanzapine is the most important issue in its treatment. The present work was carried out to evaluate the oral form of olanzapine solid lipid nanoparticles (OLZ-SLN) to overcome its poor bioavailability and compare between the effect of different doses of OLZ and OLZ-SLN on ketamineinduced schizophrenic-like symptoms. The study was extended to evaluate the adverse effects of subchronic administration of these doses of OLZ and its SLN.Methods:OLZ-SLN was prepared by hot homogenization, particle size, zeta potential and in vitro release and entrapping efficiency studies were performed. In order to assess the effective dose in the treatment of schizophrenia, the effect of different doses of OLZ and OLZ-SLN on open field was assessed and passive avoidance tests were carried out. The test was performed to examine the effects of excitatory and inhibitory amino acids, as well as dopamine and serotonin levels in the brain regions.Results and Conclusion:The new oral formula showed high stability and sustained release. The administration of low and high dose of OLZ-SLN equivalent to (1/10 and 1/20 from the therapeutic dose before ketamine attenuated the behavioral abnormalities by blocking the effect of ketamine-induced increase in glutamate, dopamine and serotonin levels and enhanced apoptosis were studied in the brain areas. In addition, the sub-chronic treatment with OLZ-SLN showed no adverse effect while the treatment with OLZ free form did.
Adolescent Depression Screening: Not So Fast
Authors: Levin Edmund C. 
Published: June 2019

Background:
Screening adolescents for depression has recently been advocated
by two major national organizations. However, this practice is not without controversy.

Objective:
To review diagnostic, clinical, and conflict of interest issues associated with the
calls for routine depression screening in adolescents.

Method:
The evaluation of depression screening by the US Preventive Services Task Force
is compared and contrasted with those of comparable agencies in the UK and Canada, and
articles arguing for and against screening are reviewed. Internal pharmaceutical industry
documents declassified through litigation are examined for conflicts of interest. A case is
presented that illustrates the substantial diagnostic limitations of self-administered mental
health screening tools.

Discussion:
The value of screening adolescents for psychiatric illness is questionable, as is
the validity of the screening tools that have been developed for this purpose. Furthermore,
many of those advocating depression screening are key opinion leaders, who are in effect
acting as third-party advocates for the pharmaceutical industry. The evidence suggests that a
commitment to marketing rather than to science is behind their recommendations, although
their conflicts of interest are hidden in what seem to be impartial third-party recommendations.
Inpatient Milieu Therapy: Considerations for Adolescent and Transitional Age Youth
Authors: Millard Hun , Parke Susan , Wilson Cynthia , Qayyum Zheala , Kim Hyun Jung , Van Deusen Timothy 
Published: June 2019

Background and Goals:
The role of milieu therapy on inpatient treatment has become
more prominent due to the changing landscape of hospital care, with shorter length of
stay, higher patient acuity, and rapid turnover. The modern inpatient unit promotes less individual
psychotherapy with the psychiatrist or therapist, and more milieu and group based
treatment that emphasizes acute stabilization.

Methods:
The authors share some of the core domains that provide the basic framework for
milieu treatment within an acute care setting when working with adolescents and transitional
age youth (TAY), with the aim to share clinical considerations for milieu therapy and offer
practical ideas for implementation in clinical practice.

Discussion:
The therapeutic milieu and collaboration of an interdisciplinary team has a significant
impact on hospital treatment. Considerations for milieu therapy implementation in
an inpatient unit include developmentally informed concepts related to milieu treatment of
adolescents and TAY patients in a hospital setting.
Mixing of Graphite with X-ray Irradiated Water Towards the Exfoliation of Graphene Layers
Authors: Dwandaru Wipsar S.B. , Pratama Buky W. , Wisnuwijaya Rhyko I. , Parwati Lia D. , Khaerudini Deni S. , Supardi  , Suparno  
Published: June 2019

Background:
This study aims to study the mixing of graphite with water irradiated by X-ray
(low energy gamma ray) towards the formation of graphene oxide (GO).

Methods:
The graphite is obtained from Zinc-Carbon (ZnC) battery wastes. This is a simple alternative
technique in synthesizing GO based on X-ray irradiation without involving additional chemicals. X-ray irradiation
is conducted upon 10 ml of distilled water using 20 kV of X-ray with irradiation time variation of
3 and 4 h. The X-ray irradiation towards the distilled water causes radiolysis to occur in the water. The
graphite solution consists of 0.6 gm of graphite in 100 ml of distilled water. The GO is formed by mixing
the X-ray irradiated water with 5 drops of the graphite solution. The sample solutions obtained are shaken
several times and left to settle for a night. The samples are then characterized using UV-Visible (UV-Vis)
and Fourier transform infra-red (FTIR) spectroscopies, and tunneling electron microscopy (TEM), whereas
scanning electron microscope and energy dispersive X-ray (SEM-EDX) characterization is done by coating
the sample on glass slides.

Results:
The UV-Vis characterization results show a red shift of absorbance peaks from 234.5 nm to 244.5
nm as the time of irradiation is increased. These peaks indicate the formation of GO in the samples. The
FTIR characterization results indicate that there are functional groups of OH, C=C, and C-O in the samples,
which also show the existence of GO. The SEM images show the surface morphology of the sample,
which resembles smooth-quadrilateral lump of clays, and the EDX result shows that the sample is composed
of 2.86%, 54.02%, 11.62%, 2.2%, 26.23%, and 3.06% of carbon, oxygen, sodium, magnesium, silicon,
and calcium atoms, respectively. The occurrence of carbon and oxygen atoms verifies further the formation
of GO in the samples.

Conclusion:
Finally, the TEM result shows few-layers of GO materials supported by the electron diffraction
pattern showing hexagonal structure of the GO.
Ammoides verticillata Essential Oil as Biocontrol Agent of Selected Fungi and Pest of Olive Tree
Authors: Senouci Hanane , Benyelles Nassira G. , Dib Mohammed EA , Costa Jean , Muselli Alain 
Published: June 2019

Background:
Ammoides verticillata Briq is an aromatic and medicinal herb that has
been widely used in folk medicine for treatment of several types of pathologies such as respiratory
problems, colds, fever, headache, gastric disorders and renal infections.

Objective:
Essential oils have been subjected of numerous works for their antimicrobial and insecticidal
properties which have been valued by hundreds of publications and patents. The main objective
of this work was to evaluate the chemical composition, and the in vitro and in vivo antifungal,
and insecticidal properties of essential oil of Ammoides verticillata.

Methods:
In this work, the air-dried aerial parts of Ammoides verticillata were hydrodistilled in a
Clevenger-type apparatus. The essential oil isolated was analyzed using gas chromatography (GC)
and mass spectrometry (GC/MS). The in vitro antifungal activity of the essential oil was investigated
against four plant fungi using radial growth technique. The effect of the essential oil on disease
development of olive caused by Penicillium crustosum and Aspergillus niger in the in vivo
conditions. The fumigation test of the essential oil was evaluated against L3 stages, pupas and
adults of Bactrocera oleae known as the olive fly.

Results:
The essential oil of A. verticillata was characterized mainly by carvacrol (44.3%), limonene
(19.3%) and p-cymene (19.2%). The result of in vitro antifungal activity of essential oil
showed an interesting antifungal inhibition against Alternaria alternata and Fusarium solani strains
with percentage inhibition of 89%. Furthermore, oil of A. verticillata has demonstrated promising
in vivo antifungal activity to control infections of olives caused by Aspergillus niger and
Penicillium crustosum. In addition, the essential oil exhibited fumigation toxicity against Bactrocera
oleae with mortality percentage of 100% at 2 μL/L air.

Conclusion:
The results showed that essential oil of A. verticillata has interesting biological activities,
which suggests that oil have the potential to be used as biocide to protect olives of pathogenic
fungi and pests.
The Ecosystem of Business Education in a Technology Environment
Authors: Frankel Jane Hartman 
Published: June 2019

:
The Knowledge Economy is the environment within which we live and work
today. It impacts all work, both within organizations and the emerging workforce. The
Knowledge Economy relies on workers’ expertise (individual knowledge) and the informed
integration of this knowledge to move an organization in a positive direction. This article
describes a Knowledge Economy program (Project-based Internships) that enables
organizations and new workforce members to experience and grasp the importance of
knowledge work in sustaining and growing organizations. This is especially applicable to
the technology domain as the founders in this area are focused on their individual
knowledge of science and technology. They often need to build sustainable organizations
with knowledge work to deliver and sustain their expert inventions and/or discoveries.

:
Knowledge work has two distinct attributes that define its orientation and operation.
Knowledge workers are autonomous in their work and they are asset-thinkers, meaning that
all work is focused on a result, which will create value for an organization. Within these two
attributes, knowledge workers also must recognize the difference between quality and
quantity, use project structures, and continuously evaluate for learning and innovation.

:
Our current education system does not recognize the individual knowledge perspective in
shaping students’ experiences. Project-based work is structured to empower and enable
students’ experiences to be knowledge work to foster this thinking and its best practices and
to create the environment that supports knowledge work within the organizations that the
knowledge worker serves.

:
Various current-day methodologies are built into the structured project work, such as The Lean
Startup, the recognition of invisible capital and growth mindsets, building knowledge work
capabilities, and, finally, building an organizational environment in which success will thrive.
Effect of Organic Acids on the Electrochemical Migration of Tin in Thin Electrolyte Layer
Authors: Liao Bokai , Cen Hongyu , Chen Zhenyu , Guo Xingpeng 
Published: June 2019

Background and Objective:
The effects of representative solder flux residue weak organic
acids on electrochemical migration (ECM) of tin in thin electrolyte layer were studied using
a technique based on the coupling of in situ electrochemical measurements and optical observations,
as well as ex situ characterizations.

Methods and Results:
The results showed that the increasing amount of weak organic acid decreased
the probability of ECM and dendrites formed were mainly composed of metallic tin. Tin
ions reacted with organic compound ions from hydrolysis of weak organic acids to form complexes
with electronegativity, which retarded the transfer of tin ions. Some complexes can be oxidized
to the insoluble tin oxides on the anode surface and blocked the dissolution of anode during tin
ECM.

Conclusion:
The growth rate of tin dendrite was found to be limited by the dissociation of complexes.
Mechanisms involved were proposed to explain the role of weak organic acid in the tin
ECM.
Un diagnóstico de la universidad mexicana en la obra El libro de la universidad imaginada
Authors: Reynoso Jaime Jenaro 
Published: June 2019

Una de las tendencias en los estudios dedicados a instituciones educativas como la universidad sostiene que la práctica investigativa tiene sentido si propone soluciones a los problemas detectados. Para este enfoque de investigación, la intervención en el funcionamiento de la institución solo puede realizarse cuando se hace sobre la base de las conclusiones que arrojan los estudios acerca de las condiciones presentes en las que aquellas funcionan; a su vez, la compresión y valoración que se hace del modo en que opera una institución solo puede lograrse después de revisar retrospectivamente el proceso que la llevó al estado en que se diagnostica.
De esa manera, la imaginación y elaboración de propuestas de solución a problemas detectados, en un aspecto o en el conjunto de la universidad, es procedente cuando quienes la ejercitan lo hacen con los vastos saberes que la formación, el estudio y la experiencia profesional les proporcionan. Tal es el caso de Eduardo Ibarra Colado, quien a partir de su experiencia académica ha promovido la escritura a ocho manos de El libro de la universidad imaginada. Hacia una universidad situada entre el buen lugar y ningún lugar, en el cual la colectividad autoral presenta a la universidad mexicana como una institución inoperante y vieja que debe cambiar hacia una propuesta que aparentemente parece utópica, pero cuyos argumentos llevan a pensarla como necesaria. Por ello, los objetivos del presente documento son ofrecer un acercamiento al concepto diagnóstico, describir la trayectoria del iniciador de la idea plasmada en el referido libro y presentar los rasgos de la universidad anquilosada, la cual, según los autores, debe desaparecer.
Kun futuuria ei ole
Authors: Helasvuo Marja-Liisa 
Published: June 2019

Arvioitu teos:
Miia Karttunen: No pittää kahttoo. Puhujan tulevan toiminnan ilmausten kielioppia ja pragmatiikkaa. Publications of the University of Eastern Finland. Dissertations in Education, Humanities, and Theology 119. Joensuu: Itä-Suomen yliopisto 2018. 256 s. isbn 978-952-61-2711-8
Tutkimus inkoatiivisista tunneverbeistä ja niiden rektioista
Authors: Huumo Tuomas , Lindström Liina 
Published: June 2019

Arvioitu teos:
Maximilian Murmann: Inchoative emotion verbs in Finnish. Argument structures and collexemes. Department of Finnish, Finno-Ugrian and Scandinavian Studies. University of Helsinki. 196 s. ja liitteet 17 s. isbn 978-951-51-4191-0. Väitöskirjan tiivistelmä on luettavissa osoitteessa https://helda.helsinki.fi/handle/10138/233975
Yhteisymmärryksen rakentaminen monikulttuurisilla lääkärin vastaanotoilla
Authors: Paananen Jenny 
Published: June 2019

Jenny Paanasen suomen kielen alaan kuuluva väitöskirja tarkastettiin Turun ylipistossa perjantaina 15. maaliskuuta 2019. Vastaväittäjänä toimi professori Esa Lehtinen Jyväksylän yliopistosta ja kustoksena professori Marja-Liisa Helasvuo.
Jenny Paananen: Yhteisymmärryksen rakentaminen monikulttuurisilla lääkärin vastaanotoilla. Turun yliopiston julkaisuja – Annales Universitatis Turkuensis C 465. Turku: Turun yliopisto 2019. Artikkeliväitöskirjan yhteenveto-osa on luettavissa osoitteessa http://urn.fi/URN:ISBN:978-951-29-7557-0