bluuebunny/crossref_metadata_2025_split huggingface dataset:
De gunfactor van herstelrecht
Authors: van Stokkom Bas 
Published: January 2019

The goodwill-factor in restorative justice – Clemency, compassion and caring for offenders
This article discusses the willingness of the victim to judge the offender more mildly after the latter apologized for his wrongdoing and shows that he is involved in behavioral change. A large group of victims wants to help (young) perpetrators and offer them a second chance, even victims who have been treated violently. It is argued that these forms of compassion express a caring attitude, the wish that the offender will be rehabilitated and that a change in behaviour is more important than compensation. This attitude can also be referred to as ‘forbearance’, in terms that a less severe sanction is sufficient. This goodwill factor may well be the most important aspect of ‘doing justice’ in restorative meetings.
Simultaneous rapid detection of Hantaan virus and Seoul virus using RT-LAMP in rats
Authors: Sui Xin , Zhang Xu , Fei Dongliang , Zhang Zhen , Ma Mingxiao 
Published: January 2019

Background
Hemorrhagic fever with renal syndrome is in most cases caused by the Hantaan virus (HTNV) and Seoul virus (SEOV). To develop and apply reverse transcription loop-mediated isothermal amplification (RT-LAMP) to detect HTNV and SEOV simultaneously, which was faster, more cost effective, and easier to perform as the target gene amplified rapidly. In this article an assay based on LAMP is demonstrated, which only employs such apparatus as a water bath or a heat block.

Methods
A chromogenic method using the calcein/Mn2+ complex and real-time turbidity monitoring method were used to assess reaction progress of the reaction, and the specificity of the RT-LAMP-based assay was assessed by detecting cDNAs/cRNAs generated from Coxsackievirus A16, Influenza virus, lymphocytic choriomeningitis virus, mouse poxvirus, rotavirus, mouse hepatitis virus. In addition, 23 clinical specimens were used to determine the agreement between the RT-LAMP assay with reverse transcriptase polymerase chain reaction (RT-PCR) and immunofluorescence (IFT) method.

Results
The detection limit of RT-LAMP to HNTV and SEOV was as low as 10 copies/μL with optimized reaction conditions, which was much more sensitive than the RT-PCR method (100–1,000 copies/μL). At the same time, the detection results of 23 clinical specimens have also illustrated the agreement between this the RT-LAMP assay with RT-PCR and IFT.

Discussion
This RT-LAMP assay could be used to perform simultaneous and rapid detection of HTNV and SEOV to the clinical specimens.
Catalytic Synthesis of N‐(5‐Methylfurfuryl)aniline from Bio‐Derived Carbohydrates
Authors: Xiao Jianjun , Jin Qi , Yang Jiaqi , Xiong Lingheng , Qiu Jumin , Jiang Jun , Peng Yang , Li Teng , Qiu Zumin , Yang Weiran 
Published: January 2019

AbstractThe value‐added chemicals derived from lignocellulosic resources are mainly oxygen‐containing compounds while nitrogen‐containing compounds are also important in the industry and ambitiously desired to be obtained from bio‐based carbohydrates. Here we report an efficient two‐step approach from fructose under mild conditions to obtain N‐(5‐methylfurfuryl)aniline, a necessary nitrogenous intermediate for some important epoxyisoindoles which have good combat‐Alzheimer's and antitumor biological activities. First, 5‐methylfurfural was prepared with HI and H3PO3 in a biphasic solution from fructose, then it was isolated and used for N‐(5‐methylfurfuryl)aniline synthesis through reductive amination catalyzed by a heterogeneous palladium catalyst. Besides, the substrate scope of the amines was examined, and most of them showed very good results. With this approach, renewable N‐(5‐methylfurfuryl)aniline was produced from fructose in an overall yield of 62%.
Cheilitis and gingivitis as first signs of Crohn's disease in a pediatric patient
Authors: Capodiferro Saverio , Maiorano Eugenio , Limongelli Luisa , Tempesta Angela , Favia Gianfranco 
Published: January 2019

Key Clinical MessageOral manifestations of Crohn's disease include gingivitis, deep ulcerations, pseudopolyps, and labial or buccal swelling; these are uncommon in children and can precede or coincide intestinal inflammation lesions, leading frequently to a delayed diagnosis.
Efficient Separation of Photogenerated Charges in a Ferroelectric Molecular Wire: Nonadiabatic Dynamics Study on 3,5‐Dicyano‐1,7‐dimethylopyrrolo[3,2‐f]indole Trimer
Authors: Jankowska Joanna , Sobolewski Andrzej L. 
Published: January 2019

AbstractIn this work we propose and verify computationally a novel idea of spontaneous separation of charges photo‐generated in a highly polar molecular “wire”. The nuclear and electronic structure of the investigated system, considering the evolution of charge carriers, are characterized at the semi‐empirical OM2/MRCI level of theory. Results point to the conclusion that 90 % of optically prepared excitons break into charge carriers (holes and electrons) localized on the opposite monomeric units of the trimer on a timescale of 30 fs. Our findings could be helpful in the design of photoactive and conducting components for molecular photovoltaic applications.
Metabolic profiling of synthetic cannabinoid 5F‐ADB by human liver microsome incubations and urine samples using high‐resolution mass spectrometry
Authors: Yeter Oya , Ozturk Yeter Erol 
Published: January 2019

Abstract5F‐ADB (methyl 2‐{[1‐(5‐fluoropentyl)‐1H‐indazole‐3‐carbonyl] amino}‐3,3‐dimethylbutanoate) is a frequently abused new synthetic cannabinoid that has been sold since at least the end of 2014 on the drug market and has been classified as an illicit drug in most European countries, as well as Turkey, Japan, and the United States. In this study, the in vitro metabolism of 5F‐ADB was investigated by using pooled human liver microsomes (HLMs) assay and liquid chromatography‐high‐resolution mass spectrometry (LC–HRMS). 5F‐ADB (5 μmol/L) was incubated with HLMs for up to 3 hours, and the metabolites were identified using LC–HRMS and software‐assisted data mining. The in vivo metabolism was investigated by the analysis of 30 authentic urine samples and was compared to the data received from the in vitro metabolism study. Less than 3.3% of the 5F‐ADB parent compound remained after 1 hour of incubation, and no parent drug was detected after 3 hours. We identified 20 metabolites formed via ester hydrolysis, N‐dealkylation, oxidative defluorination, hydroxylation, dehydrogenation, further oxidation to N‐pentanoic acid and glucuronidation or a combination of these reactions in vitro. In 12 urine samples (n = 30), 5F‐ADB was detected as the parent drug. Three of the identified main metabolites 5F‐ADB carboxylic acid (M20), monohydroxypentyl‐5F‐ADB (M17), and carboxypentyl ADB carboxylic acid (M8) were suggested as suitable urinary markers. The screening of 8235 authentic urine samples for identified 5F‐ADB metabolites in vitro resulted in 3135 cases of confirmed 5F‐ADB consumption (38%).
A plasma‐fluid model for EHD flow in DBD actuators and experimental validation
Authors: Mushyam A. , Rodrigues F. , Pascoa J.C. 
Published: January 2019

SummaryA numerical method to simulate plasma induced electrohydrodynamic flow is proposed in this study. The numerical model consists of three components. Firstly, a potential module to simulate temporal potential and electric field generated in the ionized fluid. Secondly, a plasma module to simulate plasma development and charge particle densities. Finally, a fluid module to simulate the flow affected by the body forces induced by the movement of the charged particles. Fluid flow is modeled using modified predictor‐corrector strategy as proposed in the marker and cell method. The velocity field was corrected to achieve incompressible flow by calculating pressure correction factors, considered in all cells. Numerical convergence and time sensitivity analysis were carried to confirm grid independence and determine an efficient time step for simulations. Numerical computations are validated by comparing with experimental results of discharge currents and current densities. They were found to be in very good agreement thus providing an extensive validation. Furthermore, quiescent flow over a dielectric barrier discharge actuator is simulated in the this study, using the proposed plasma‐fluid model, to model flow evolution and resolve temporal flow features for detailed analysis. The streamline and vorticity plots were analyzed and compared with experimental results, and flow results were found to be in‐line with the experiments.
Preoperative quality‐of‐life measures predict acute postoperative pain in endoscopic sinus surgery
Authors: Chowdhury Naweed I. , Turner Justin H. , Dorminy Cindy , Wu Jeffanie , Chandra Rakesh K. 
Published: January 2019

ObjectivesRecent increases in opioid‐related mortality have prompted a critical evaluation of postoperative pain management across all specialties. However, successfully limiting narcotic overprescription requires perioperative identification of patients who are at risk for high postoperative pain. Unfortunately, quality data to guide practice patterns are lacking. We therefore prospectively investigated several possible predictive factors of postoperative pain after endoscopic sinus surgery (ESS).MethodsSixty‐four consecutive patients undergoing ESS were enrolled. Baseline 22‐item SinoNasal Outcomes Test (SNOT‐22) and Short‐Form 8 (SF‐8) scores were obtained. Pain scores were collected postoperatively using a numeric rating scale. Spearman correlations and univariate linear regression models were used to investigate relationships between postoperative pain, patient factors, and SNOT‐22/SF‐8 domain scores. Multivariate linear regression was then performed to control for potential confounding variables.ResultsDay‐of‐surgery pain scores were significantly correlated with the SF‐8 role‐physical domain (Rs = 0.32, P = 0.04). Whereas SF‐8 pain scores were initially nonsignificant, at postoperative day 3 (POD3) the preoperative SF‐8 pain score became correlated with self‐reported pain (Rs = 0.39, P = 0.02). SNOT‐22 total and subdomain scores were not associated with pain scores at any time point. Multivariate linear regression modelling identified baseline SF‐8 role‐physical and pain scores, smoking status, and undergoing a modified Lothrop procedure as significant independent predictors of POD3 pain (adjusted R2 = 0.359, P < 0.0001).ConclusionBaseline patient‐reported global quality‐of‐life measures are associated with postoperative pain after ESS. Large multicenter studies are necessary to validate these findings and investigate additional factors associated with postoperative pain following ESS.Level of Evidence2cLaryngoscope, 129:1274–1279, 2019
Cell free fetal DNA to triage antenatal rhesus immune globulin: Is it really cost‐effective in the United States?
Authors: Moise Kenneth J. , Hashmi Syed Shahrukh , Markham Kara , Argoti Pedro S. , Bebbington Michael 
Published: January 2019

What is already known about this topic?

Cell free DNA can accurately predict the fetal RHD status.
What does this study add?

Use of cell free DNA to determine the fetal RHD status to triage the use of antenatal rhesus immune globulin is not a cost‐effective strategy for implementation in the United States.
Universal rhesus antenatal immune globulin without consideration for paternity is the most effective strategy for preventing new cases of RhD alloimmunization.
Global transcriptome analysis and differentially expressed genes in grapevine after application of the yeast‐derived defense inducer cerevisane
Authors: De Miccolis Angelini Rita M , Rotolo Caterina , Gerin Donato , Abate Domenico , Pollastro Stefania , Faretra Francesco 
Published: January 2019

AbstractBACKGROUNDCerevisane, made up of cell wall derivatives from the Saccharomyces cerevisiae strain LAS117, is proposed as a resistance inducer in plants. The mode of action of cerevisane was investigated through transcriptome analysis (RNA‐Seq) carried out on leaves of potted vines cv. Italia grown in the greenhouse and sprayed at 1‐week intervals with cerevisane. Analyses were performed at three time points after one and three sprays as well as on vines challenged with artificial inoculation with Plasmopara viticola, Erysiphe necator and Botrytis cinerea.RESULTSCerevisane proved effective against downy mildew and caused an increase in expression levels of several genes related to defense responses to fungal pathogens and other stresses and down‐regulation of genes involved in several processes related to plant growth and development. Up‐regulated genes included genes encoding (i) enzymes involved in hormone metabolism (i.e. salicylic acid, jasmonate, ethylene) and related plant responses, (ii) defense compounds (i.e. pathogenesis‐related proteins, phenylalanine ammonia‐lyase, stilbene synthases, lipoxygenase, leucine‐rich repeat receptor‐like protein kinases, non‐specific plant lipid transfer proteins, serine–threonine protein kinases involved in signal transduction, superoxide dismutase and glutathione S‐transferase involved in response to oxidative stress), (iii) secondary metabolites (i.e. phenylpropanoids, terpenoids, lignin), and (iv) photosynthetic processes (light harvesting chlorophyll A/B‐binding proteins and components of the photosystems).CONCLUSIONCerevisane can be a useful tool in protection schedules against downy mildew on grapevine aimed at reducing the usage of synthetic fungicides and preventing fungicide resistance. The results provide the first basic knowledge on the mode of action of yeast‐derived elicitors effective against P. viticola on grapevine. © 2019 Society of Chemical Industry
Feuerwiderstand verzinkter Stahlkonstruktionen
Authors: Mensinger Martin , Gaigl Christian 
Published: January 2019

AbstractIst eine Feuerwiderstandsdauer von mindestens 30 min erforderlich, muss sichergestellt werden, dass das Tragverhalten im Brandfall den statischen Anforderungen genügt. Stand der Technik, um Stahlkonstruktionen vor zu hohen Temperaturen in der außergewöhnlichen Bemessungssituation eines Brands zu schützen, ist ein passiver Brandschutz. Der Eurocode bietet aber auch rechnerische Nachweisverfahren, um den Brandschutznachweis zu erfüllen. Dabei ist die Bauteiltemperatur nach DIN EN 1993‐1‐2 zu bestimmen und der Tragfähigkeitsnachweis unter Berücksichtigung der Abminderung der Materialkennwerte zu führen. Zu diesem Zweck wurden in einem Forschungsprojekt der Technischen Universität München positive Effekte der Feuerverzinkung auf die Temperaturentwicklung von Stahlbauteilen unter Brandeinwirkung untersucht. Ziel ist es, eine R30‐Brandschutzanforderung durch ungeschützte, feuerverzinkte Stahlbauteile zu ermöglichen.
Ausgezeichnete Hochhäuser
Authors: Möller Eberhard 
Published: January 2019

AbstractSeit der Geburtsstunde des modernen Hochhauses im Chicago der 1880er‐Jahre ist dieser Bautypus eine Domäne des Stahlbaus. Gemeinsam mit der Erfindung einer Sicherheitsfangtechnik für Aufzüge hat die industrielle Stahlproduktion den Wettlauf in die Höhe angefacht und in immer neue Dimensionen getrieben. Betrachtet man vor diesem Hintergrund die aktuellen Entwicklungen im Hochhausbau – noch bis zum 3. März 2019 sehr anschaulich und informativ präsentiert in der Ausstellung zum Hochhaus Preis 2018/19 im Deutschen Architekturmuseum in Frankfurt am Main –, lässt sich ein deutlicher Wandel ablesen. Zunehmend verwenden Ingenieure und Architekten neben Stahl auch Beton – und das nicht nur im Verborgenen für das Tragwerk, sondern auch offen sichtbar in der Fassade. Einen Überblick über aktuelle Tendenzen bieten die fünf ausgestellten Wolkenkratzer der engeren Wahl.
Die neue Ankunftshalle am Bahnhof St. Gallen
Authors: Kunze Matthias , Kern Urs 
Published: January 2019

AbstractDie neue Ankunftshalle ist ein Schlüsselteilprojekt der 2018 abgeschlossenen Neugestaltung des Bahnhofs und Bahnhofplatzes St. Gallen (CH). Das 26 m lange, 22,5 m breite und 14 m hohe Bauwerk bildet das Tor zur Personenunterführung Ost und aufgrund seiner zentralen Lage zwischen Bahnhofplatz, ‐gebäude und Gleisen einen wichtigen Orientierungspunkt für die Passagierströme. Das architektonische Konzept „Akari” – ein japanischer Ausdruck für Helligkeit, Licht und Schwerelosigkeit – prägt das Erscheinungsbild der Halle, das von einem klaren und regelmäßigen Tragwerk und einer transluziden Gebäudehülle hervorgerufen wird. Ein vierfach punktgestützter Stahlträgerrost aus Flachstahl‐Blechträgern bildet die Dachkonstruktion, der kassettenartig ausgebildete Rost kragt allseitig über die Stützenachsen aus. Die vier an ihrem Fuß und im Trägerrost eingespannten Rahmenstützen gewährleisten den vertikalen Lastabtrag sowie die Stabilisierung des Bauwerks. An den Dachrändern wurden die hängenden Stahlschwerter als Träger der Fassaden unmittelbar an die Kragträger des Dachs biegesteif angeschlossen. Direkt auf dem Stahlbau befestigte quadratische Glasscheiben bilden die Dachhaut, im Bereich der Fassaden sind die Gläser mittels Chromstahlkonsolen an je vier Punkten gehalten und sowohl horizontal wie auch vertikal überschuppt.
Glas im Bauwesen – Verglasungen mit Zusatzanforderungen
Authors: Hamm Hermann 
Published: January 2019

AbstractMit der baurechtlichen Einführung der Normenreihe DIN 18008 „Glas im Bauwesen – Bemessungs‐ und Konstruktionsregeln” vor etwa drei Jahren wurden die bis dahin gültigen Technischen Regeln des Deutschen Instituts für Bautechnik, Berlin (DIBt), i. E. TRLV, TRAV und TRPV, zurückgezogen. Im vorliegenden Beitrag werden die wesentlichen Inhalte für Verglasungen mit Zusatzanforderungen erläutert. Hierbei handelt es sich um absturzsichernde Verglasungen nach Teil 4, begehbare Verglasungen nach Teil 5 sowie zu Instandhaltungsmaßnahmen betretbare und durchsturzsichere Verglasungen nach Teil 6.Bei allen drei der vorgenannten Normenteile stehen die Stoßsicherheit sowie das Resttragverhalten nach Glasbruch im Vordergrund. Über die raumtrennende Funktion hinaus werden bei Verglasungen besondere Anforderungen an das Tragverhalten gestellt, um Personen vor Verletzungen bei oder nach Glasbruch zu schützen. Dies gelingt durch Beachtung konstruktiver Vorgaben sowie durch Verwendung von Verglasungen, denen sog. „sicheres Bruchverhalten” wie auch die Eigenschaft der Resttragfähigkeit zugewiesen werden kann.
Epidemiologic trends for isolated tibia shaft fracture admissions in The Netherlands between 1991 and 2012
Authors: Leliveld Mandala S. , Polinder Suzanne , Panneman Martien J. M. , Verhofstad Michael H. J. , Van Lieshout Esther M. M. 
Published: January 2019

Abstract

Introduction
Population-based knowledge on the occurrence of specific injuries is essential for the allocation of health care services, optimization of preventive measures, and research purposes. Therefore, the aim of this study was to examine long-term nation-based trends in the incidence rate, trauma mechanism, hospital length of stay (HLOS), treatment, and outcome of hospital-admitted patients with an isolated tibia shaft fracture between 1991 and 2012 in The Netherlands.

Methods
All hospital-admitted patients in The Netherlands between 1991 and 2012 with an isolated tibia shaft fracture were included. Age and gender-standardized incidence rates were calculated for each year. Data were extracted from the National Medical Registration.

Results
The incidence rate for men decreased to 13.8/100,000 person years (py). For women the incidence rate remained stable with 7.2/100,000 py. Incidence showed a peak for adolescent men (15–19 years), and increased in both genders from 65 years onwards. Since 1993 the mean HLOS for isolated tibia fractures reduced from 10.8 to 5.4 days. Mean HLOS increased with age. Mean years lived with disability (YLD) was 4.5 years, declined linearly with age, and showed no gender effect.

Conclusions
In 22 years, the incidence rate of hospital admitted patients with an isolated tibia shaft fracture in The Netherlands dropped with 12%, which was mainly attributable to a 15% decline among men. Incidence rate, trauma mechanism, and HLOS were age and gender related. HLOS also reduced over time. Operation rate and YLD were only age related.
Field Line Resonance in the Hermean Magnetosphere: Structure and Implications for Plasma Distribution
Authors: James Matthew K. , Imber Suzanne M. , Yeoman Timothy K. , Bunce Emma J. 
Published: January 2019

AbstractThe first statistical survey of field line resonance (FLR) events is presented using magnetometer data from the entire MErcury Surface, Space ENvironment, GEochemistry and Ranging mission. Ultralow‐frequency waves are an important tool for the magnetoseismology of the Hermean magnetosphere; this study provides a completely new window onto the resonance structures and plasma density distribution in the Hermean magnetosphere. Here we assess resonance events from two categories—toroidal resonances characteristic of the classical picture of FLRs in the terrestrial magnetosphere driven by the Kelvin‐Helmholtz instability and a more comprehensive approach including all observed transverse resonances with more relaxed polarization criteria. Two hundred twenty‐three toroidal FLRs with characteristics consistent with Kelvin‐Helmholtz‐driven FLRs are found in the dayside Hermean magnetosphere. The fundamental frequencies of these waves are used to provide estimates of plasma mass density in the range of ∼ 1–650 amu/cm3. A further 343 transverse resonances are found which provide very similar density estimates to the Earth‐like FLR population. Fundamental and harmonic frequencies from all 566 events are used to fit a power law to plasma mass density along the field lines. The equatorial plasma mass density is predicted to vary approximately with R−7.5. The offset of the Hermean dipole into the northern hemisphere causes significant asymmetries in the standing wave structure. Due to the extreme warping (away from a dipolar configuration) of Mercury's magnetosphere by the solar wind, the fundamental toroidal mode is predicted to oscillate with a notably lower frequency than the fundamental poloidal mode, contrary to relative toroidal and poloidal frequencies modeled for Earth's magnetosphere.
An Analytic Method for Computing the Infinite Sums Occurring in the Geoelastic Disk Load Problem
Authors: Fowler J. , Ogle C. , Bevis M. 
Published: January 2019

AbstractThe elastic displacements caused by a point load imposed on the surface of a layered, spherical, and self‐gravitating Earth can be expressed in terms of infinite series of Legendre polynomials or their derivatives, multiplied by constants, called Love numbers, that depend on the summation index or degree. Truncating these infinite series causes oscillatory errors in the computed displacement field, particularly in the near field of the load, but Farrell (1972, https://doi.org/10.1029/RG010i003p00761) circumvented this problem using a Kummer transformation that relied on an asymptotic approximation for the Love number spectrum and three useful identities for series of Legendre polynomials. Unfortunately, nobody has determined a similar work‐around for the disk load problem since in this case the infinite expansions consist of products of Legendre polynomials or their derivatives, and no similarly useful identities have been identified to date. We present an alternative means to the same general goal by replacing the infinite series with closed‐form expressions involving elliptic integrals.