bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serial Ottawa 3DY assessments to detect delirium in older emergency department community dwellers
Authors: Yadav Krishan , Boucher Valérie , Carmichael Pierre-Hugues , Voyer Philippe , Eagles Debra , Pelletier Mathieu , Gouin Émilie , Daoust Raoul , Vu Thien Tuong Minh , Berthelot Simon , Émond Marcel 
Published: October 2019

Abstract

Background
delirium is associated with increased morbidity and mortality among older emergency department (ED) patients. When using physician gestalt, delirium is missed in the majority of patients. The Ottawa 3DY (O3DY) has been validated to detect cognitive dysfunction among older ED patients.

Objectives
to determine the sensitivity and specificity of serial O3DY assessments to detect delirium in older ED patients.

Design
a prospective observational multicenter cohort study.

Setting
four Quebec EDs.

Participants
independent or semi-independent older patients (age ≥ 65 years) with an ED stay of at least 8 hours that required hospitalisation.

Measurements
eligible patients were evaluated using serial O3DY assessments at least 6 hours apart. The primary outcome was delirium after at least 8 hours in the ED. The reference standard for delirium assessment was the confusion assessment method (CAM). The sensitivity and specificity of the serial O3DY to detect delirium were calculated.

Results
we enrolled 301 patients (mean age 77 years, 49.5% male, 3.0% with a history of mild dementia). Thirty patients (10.0%) were CAM positive for delirium. Patients had a median of three O3DY assessments. Serial O3DY evaluations to detect delirium among patients with at least one abnormal O3DY had a sensitivity of 86.7% (95% confidence interval—CI 69.3–96.2%) and a specificity of 44.3% (95%; CI 38.3–50.4%).

Conclusion
serial O3DY testing demonstrates good sensitivity as a screening tool to detect delirium among older adult patients with prolonged ED lengths of stay. Emergency physicians should consider the use of the serial O3DY over clinician gestalt to improve delirium detection.
Population-Level Sexual Mixing According to HIV Status and Preexposure Prophylaxis Use Among Men Who Have Sex With Men in Montreal, Canada: Implications for HIV Prevention
Authors: Wang Linwei , Moqueet Nasheed , Lambert Gilles , Grace Daniel , Rodrigues Ricky , Cox Joseph , Lachowsky Nathan J , Noor Syed W , Armstrong Heather L , Tan Darrell H S , Burchell Ann N , Ma Huiting , Apelian Herak , Knight Jesse , Messier-Peet Marc , Jollimore Jody , Baral Stefan , Hart Trevor A , Moore David M , Mishra Sharmistha 
Published: October 2019

Abstract
Using cross-sectional survey data (Engage, 2017–2018) from 1,137 men who have sex with men, ≥16 years old, in Montreal, we compared observed human immunodeficiency virus (HIV) seroconcordance in previous-6-months’ sexual partnerships with what would have been observed by chance if zero individuals serosorted. Of 5 recent partnerships where both individuals were HIV-negative, we compared observed concordance in preexposure prophylaxis (PrEP) use with the counterfactual if zero individuals selected partners based on PrEP use. We estimated the concordance by chance using a balancing-partnerships approach assuming proportionate mixing. HIV-positive respondents had a higher proportion of HIV-positive partners (66.4%, 95% confidence interval (CI): 64.0, 68.6) than by chance (23.9%, 95% CI: 23.1, 24.7). HIV-negative respondents (both on and not on PrEP) had higher proportions of HIV-negative partners (82.9% (95% CI: 81.1, 84.7) and 90.7% (95% CI: 89.6, 91.7), respectively) compared with by chance (76.1%, 95% CI: 75.3, 76.9); however, those on PrEP had a higher proportion of HIV-positive partners than those not on PrEP (17.1% (95% CI: 15.3, 18.9) vs. 9.3% (95% CI: 8.3, 10.4). Those on PrEP also had a higher proportion of partners on PrEP among their HIV-negative partners (50.6%, 95% CI: 42.5, 58.8) than by chance (28.5%, 95% CI: 27.5, 29.4). The relationship between PrEP and sexual-mixing patterns demonstrated by less population-level serosorting among those on PrEP and PrEP-matching warrants consideration during PrEP roll-out.
Reduced Microstructural Lateralization in Males with Chronic Schizophrenia: A Diffusional Kurtosis Imaging Study
Authors: McKenna Faye , Babb James , Miles Laura , Goff Donald , Lazar Mariana 
Published: October 2019

AbstractDecreased brain lateralization is considered a trait marker of schizophrenia. Whereas reductions in both functional and macrostructural gray matter laterality in schizophrenia are well established, the investigation of gray matter microstructural lateralization has so far been limited to a small number of ex vivo studies, which limits the understanding of neurobiological substrates involved and development of adequate treatments. The aim of the current study was to assess in vivo gray matter microstructure lateralization patterns in schizophrenia by employing the diffusion kurtosis imaging (DKI)–derived mean kurtosis (MK) metric. MK was calculated for 18 right-handed males with chronic schizophrenia and 19 age-matched healthy control participants in 46 bilateral gray matter regions of interest (ROI). Microstructural laterality indexes (μLIs) were calculated for each subject and ROI, and group comparisons were conducted across regions. The relationship between μLI values and performance on the Wisconsin Card Sorting Test (WCST) was also evaluated. We found that compared with healthy controls, males with chronic schizophrenia had significantly decreased μLI across cortical and subcortical gray matter regions, which was correlated with poorer performance on the WCST. Our results suggest the ability of DKI-derived MK to capture gray matter microstructural lateralization pathology in vivo.
A Neural Mechanism of Cue-Outcome Expectancy Generated by the Interaction Between Orbitofrontal Cortex and Amygdala
Authors: Takei Kenji , Fujita Kazuhisa , Kashimori Yoshiki 
Published: October 2019

AbstractTaste perception is important for animals to take adequate nutrients and avoid toxins for their survival. Appetitive and aversive behaviors are produced by value evaluation of taste and taste expectation caused by other sensations. The value evaluation, coupled with a cue presentation, produces outcome expectation and guides flexible behaviors when the environment is changed. Experimental studies demonstrated distinct functional roles of basolateral amygdala (ABL) and orbitofrontal cortex (OFC) in value evaluation and adaptive behavior. ABL is involved in generating a cue–outcome association, whereas OFC makes a contribution of generating a cue-triggered expectation to guide adaptive behavior. However, it remains unclear how ABL and OFC form their functional roles, with the learning of adaptive behavior. To address this issue, we focus on an odor discrimination task of rats and develop a computational model that consists of OFC and ABL, interacting with reward and decision systems. We present the neural mechanisms underlying the rapid formation of cue–outcome association in ABL and late behavioral adaptation mediated by OFC. Moreover, we offer 2 functions of cue-selective neurons in OFC: one is that the activation of cue-selective neurons transmits value information to decision area to guide behavior and another is that persistent activity of cue-selective neurons evokes a weak activity of taste-sensitive OFC neurons, leading to cue-outcome expectation. Our model further accounts for ABL and OFC responses caused by lesions of these areas. The results provide a computational framework of how ABL and OFC are functionally linked through their interactions with the reward and decision systems.
Multisensory interactions underlying flavor consumption in rats: the role of experience and unisensory component liking
Authors: Elliott Victoria E , Maier Joost X 
Published: October 2019

Abstract
The mechanisms by which taste and odor are combined in determining food choice behavior are poorly understood. Previous work in human subjects has yielded mixed results, potentially due to differences in task context across studies, and a lack of control over flavor experience. Here, we used rats as a model system to systematically investigate the role of experience and unisensory component liking in the multisensory interactions underlying consumption behavior. We demonstrate that taste–smell mixture consumption is best explained by a linear average of component liking. The observed pattern of results was not dependent on prior experience with specific taste–smell combinations, and unique for multisensory as opposed to unisensory mixture consumption. The results are discussed with respect to existing models of flavor integration, and a maximum-likelihood integration model previously described for multisensory judgments in other systems.
National Trends in Incidence of Purulent Skin and Soft Tissue Infections in Patients Presenting to Ambulatory and Emergency Department Settings, 2000–2015
Authors: Fritz Stephanie A , Shapiro Daniel J , Hersh Adam L 
Published: October 2019

AbstractNationally representative data from 2000–2015 demonstrated a rise in the incidence of outpatient visits for skin infections, peaking in 2010–2013, followed by a plateau. While cephalexin was the most frequently prescribed antibiotic at the beginning, trimethoprim-sulfamethoxazole was most frequently prescribed by the end of the study period.
Effects of a medium cut-off (Theranova®) dialyser on haemodialysis patients: a prospective, cross-over study
Authors: Cozzolino Mario , Magagnoli Lorenza , Ciceri Paola , Conte Ferruccio , Galassi Andrea 
Published: October 2019

AbstractBackgroundDespite significant advances in haemodialysis (HD) in recent decades, current dialysis techniques are limited by inadequate removal of uraemic solutes such as middle molecules and protein-bound uraemic toxins. Novel medium cut-off (MCO) membrane or ‘expanded haemodialysis’ (HDx) provides diffusive removal of conventional and large middle molecular weight uraemic toxins, with marginal albumin leak.MethodsThis prospective, open-label, controlled, cross-over pilot study compared HDx (novel MCO membrane Theranova® 400) and conventional HD in 20 prevalent HD patients. Biochemical, dialysis adequacy and safety measures (adverse events, infections and hospitalization frequency) were recorded. Ten patients underwent conventional HD high-flux dialyser and 10 patients underwent HDx for 3 months, and the patients then switched and received the other treatment for a further 3 months.ResultsTreatment with HDx was associated with a significant reduction in serum albumin concentration [median (interquartile range) reduction −0.45 g/dL (−0.575 to −0.05); P = 0.025]. However, median albumin levels were ≥3.5 g/dL and no patients had clinical symptoms of hypoalbuminaemia or needed intravenous albumin administration. The number of infections was lower in patients treated with HDx (n = 7/19) compared with patients treated with HD (n = 14/20; P = 0.03). Patients treated with HDx had reduced levels of interleukin (IL)-1β (from 0.06 ± 0.02 pg/mL versus 0.28 ± 0.18 pg/mL with HD) and IL-6 (6.45 ± 1.57 pg/mL versus 9.48 ± 2.15 pg/mL), while tumour necrosis factor-α levels remain unchanged.ConclusionsThis study demonstrates that the chronic use of the novel MCO dialyser Theranova® appears to be safe and well-tolerated, without serious side effects or hypoalbuminaemia, as well as fewer infections. These results need to be confirmed in larger randomized clinical trials.
Translation as Creative Process: Elaine Feinstein’s Marina Tsvetaeva
Authors: Impens Florence 
Published: October 2019

Abstract
This essay sheds new light on Elaine Feinstein’s Selected Poems by Marina Tsvetaeva (1971). This publication was crucial, not only in introducing Tsvetaeva to a larger Anglophone audience, but also in influencing Feinstein’s career. Its importance is the more remarkable, as Feinstein was then neither a Russian specialist nor a translator. Using archival material, the essay shows, first, how Feinstein’s versions of Tsvetaeva’s poems present a personal perspective on the Russian writer, echoing Feinstein’s poetic concerns at the turn of the 1970s and, second, how she used these drafts to test new creative possibilities that could be harnessed for her own future practice. More broadly, this is a case study of the links between literary translation and creative writing, when the poet has no previous knowledge of the source language.
Preoperative and intraoperative argatroban as anticoagulant for bridging a patient with heparin-induced thrombocytopaenia to lung transplantation
Authors: Oh Dong Kyu , Kim Dong Kwan , Choi Sehoon , Hong Sang-Bum 
Published: October 2019

Abstract
A 65-year-old male was bridged to lung transplantation with veno-venous extracorporeal membrane oxygenation (ECMO). After experiencing heparin-induced thrombocytopaenia, heparin was replaced with argatroban. After 24 days, bilateral sequential lung transplantation was performed with argatroban anticoagulation. Intraoperative argatroban doses ranged between 0.4 and 0.6 μg/kg/min, resulting in activated clotting time of 169–216 s and activated partial thromboplastin time of 45–75 s. The patient was weaned from ECMO immediately after lung transplantation, and no bleeding or thrombotic complications were observed. He was discharged home on postoperative day 140.
Effects of atrial natriuretic peptide on renal function during cardiopulmonary bypass: a randomized pig model
Authors: Kolsrud Oscar , Damén Tor , Nygren Andreas , Ricksten Sven-Erik , Tholén Maria , Hjärpe Anders , Laffin Anna , Dellgren Göran 
Published: October 2019

Abstract

OBJECTIVES
Acute kidney injury is a well-known complication after cardiac surgery and cardiopulmonary bypass (CPB). In this experimental animal study, we evaluated the effects of atrial natriuretic peptide (ANP) on renal function, perfusion, oxygenation and tubular injury during CPB.

METHODS
Twenty pigs were blindly randomized to continuous infusion of either ANP (50 ng/kg/min) or placebo before, during and after CPB. Renal blood flow as well as cortical and medullary perfusion was measured. Blood was repeatedly sampled from the renal vein. Glomerular filtration rate was measured by infusion clearance of 51Cr-EDTA.

RESULTS
Glomerular filtration rate was higher (P < 0.001), whereas renal blood flow or renal oxygen delivery was not affected by ANP during CPB. Renal oxygen consumption did not differ between groups during CPB, whereas renal oxygen extraction was higher in the ANP group (P = 0.03). Urine flow and sodium excretion were higher in the ANP group during CPB. Blood flow in the renal medulla, but not in the cortex, dropped during CPB, an effect that was not seen in the animals that received ANP.

CONCLUSIONS
ANP improved renal function during CPB. Despite impaired renal oxygenation, ANP did not cause tubular injury, suggesting a renoprotective effect of ANP during CPB. Also, CPB induced a selectively reduced blood flow in the renal medulla, an effect that was counteracted by ANP.
Selection imposed by local environmental conditions drives differences in microbial community composition across geographically distinct groundwater aquifers
Authors: Fillinger Lucas , Hug Katrin , Griebler Christian 
Published: October 2019

ABSTRACT
Several studies have analyzed biogeographic distribution patterns of microbial communities across broad spatial scales. However, it is often unclear to what extent differences in community composition across different regions are caused by dispersal limitation or selection, and if selection is caused by local environmental conditions alone or additional broad-scale region-specific factors. This is especially true for groundwater environments, which have been understudied in this context relative to other non-subsurface habitats. Here, we analyzed microbial community composition based on exact 16S rRNA amplicon sequence variants (ASVs) from four geographically separated aquifers located in different regions along a latitudinal transect of ∼700 km across Germany. Using a combination of variation partitioning and ecological null models revealed that differences in microbial community composition were mainly the product of selection imposed by local environmental conditions and to a smaller but still significant extent dispersal limitation and drift across regions. Only ∼23% of the total variation in microbial community composition remained unexplained, possibly due to underestimated effects of dispersal limitation among local communities within regions and temporal drift. No evidence was found for selection due to region-specific factors independent of local environmental conditions.
Free fatty acids promote transformation efficiency of yeast
Authors: Duan Xingpeng , Ma Xiaojing , Li Shengying , Zhou Yongjin J 
Published: October 2019

ABSTRACT
High transformation efficiency is essential in genetic engineering for functional metabolic analysis and cell factory construction, in particular in construction of long biosynthetic pathways with multiple genes. Here, we found that free fatty acid (FFA)-overproducing strain showed higher transformation efficiency in Saccharomyces cerevisiae. We then verified that external supplementation of FFAs, to the culture media for competent cell preparation, improved yeast transformation efficiency significantly. Among all tested FFAs, 0.5 g/L C16:0 FFA worked best on promoting transformation of S. cerevisiae and Komagataella phaffii (previously named as Pichia pastoris). Furthermore, C16:0 FFA improved the assembly efficiency of multiple DNA fragments into large plasmids and genome by 100%, which will facilitate the construction and optimization of multigene-containing long pathways.
On enzymatic remodeling of IgG glycosylation; unique tools with broad applications
Authors: Sjögren Jonathan , Lood Rolf , Nägeli Andreas 
Published: October 2019

AbstractThe importance of IgG glycosylation has been known for many years not only by scientists in glycobiology but also by human pathogens that have evolved specific enzymes to modify these glycans with fundamental impact on IgG function. The rise of IgG as a major therapeutic scaffold for many cancer and immunological indications combined with the availability of unique enzymes acting specifically on IgG Fc-glycans have spurred a range of applications to study this important post-translational modification on IgG. This review article introduces why the IgG glycans are of distinguished interest, gives a background on the unique enzymatic tools available to study the IgG glycans and finally presents an overview of applications utilizing these enzymes for various modifications of the IgG glycans. The applications covered include site-specific glycan transglycosylation and conjugation, analytical workflows for monoclonal antibodies and serum diagnostics. Additionally, the review looks ahead and discusses the importance of O-glycosylation for IgG3, Fc-fusion proteins and other new formats of biopharmaceuticals.
Derived Equivalences for Symplectic Reflection Algebras
Authors: Losev Ivan 
Published: October 2019

AbstractIn this paper we study derived equivalences for symplectic reflection algebras. We establish a version of the derived localization theorem between categories of modules over these algebras and categories of coherent sheaves over quantizations of $\mathbb{Q}$-factorial terminalizations of the symplectic quotient singularities. To do this we construct a Procesi sheaf on the terminalization and show that the quantizations of the terminalization are simple sheaves of algebras. We will also sketch some applications to the generalized Bernstein inequality and to perversity of wall crossing functors.
Computer-Mediated Communication in the Age of Communication Visibility
Authors: Treem Jeffrey W , Leonardi Paul M , van den Hooff Bart 
Published: October 2019

AbstractThis article argues that a distinctive aspect of computer-mediated communication (CMC) is the way it can make communication visible to others in ways that were previously impractical. We propose a theory of communication visibility that recognizes its multidimensional nature: resulting from activities that make communication visible, efforts by actors to see communication, and a sociomaterial context that influences possibilities for visibility. The different dimensions of communication visibility are explored as they relate to possibilities for action with CMC, and the ability of third-parties to view communication between others. Centering communication visibility in the study of CMC compels scholars to ask new questions regarding the interdependence of active, strategic efforts to make communication more or less visible to others, and the ways in which communication is assessed by observers. To facilitate ongoing research we offer an agenda for incorporating communication visibility into the study of contemporary and future forms of CMC.
Decay of Thermal Tolerance in Queensland Fruit Fly Eggs (Bactrocera tryoni, Diptera: Tephritidae) Following Non-Lethal Heat Hardening
Authors: Brown S D J , Jamieson L E , Laidlaw W G , de Silva N , Waddell B C 
Published: October 2019

Abstract
Quarantine disinfestation treatments for Queensland fruit fly (Bactrocera tryoni (Froggatt)) have been developed which use high temperatures to kill preimaginal life stages within fruit prior to export. However, thermal tolerance of individuals can be increased if they are exposed to elevated temperatures before disinfestation treatment. The rate that this thermal conditioning decays after exposure, and the effect of temperature on this decay process, were investigated. Eggs of B. tryoni were exposed to a nonlethal hot water treatment at 38°C for 15 min, 1 or 3 h, then held in air at 25°C for times ranging from 15 min to 12 h, before being exposed to hot water disinfestation at 46°C for various times. From each of these cohorts, the lethal time for 99% mortality (LT99) was calculated. The LT99 of B. tryoni eggs increased with longer conditioning times at 38°C. For each conditioning time, the LT99 decreased with longer delay periods at 25°C prior to disinfestation. The rate of decrease was greatest during the first hour of delay, after which the rate of decrease slowed and tended toward zero. This induction and decay was modeled using a double-exponential equation. These experiments show that thermal conditions prior to disinfestation, and the time delay before the procedure commences, both influence the response of the insect to the disinfestation treatment. These results have implications for the specification of postharvest quarantine treatments, which are usually expressed only in terms of a fruit-center target temperature.
Can skilled immigration raise innovation? Evidence from Canadian Cities
Authors: Blit Joel , Skuterud Mikal , Zhang Jue 
Published: October 2019

Abstract
We examine the effect of changes in skilled-immigrant population shares in 98 Canadian cities on per capita patents. The Canadian case is of interest because its ‘points system’ is viewed as a model of skilled immigration policy. Our estimates suggest that the impact of increasing the university-educated immigrant share on patenting rates is modest at best and unambiguously smaller than the impact of skilled immigrants in the USA. We find larger effects of Canadian science, engineering, technology or mathematics (STEM)-educated immigrants employed in STEM jobs, but this impact is limited because only one-third of Canadian STEM-educated immigrants are employed in STEM jobs, compared with two-fifths of native-born Canadians and one-half of US immigrants. Our findings suggest that for most countries, skilled immigration is unlikely to be a panacea for sluggish innovation and that the US experience may be exceptional.