bluuebunny/crossref_metadata_2025_split huggingface dataset:
International migration of health labour: monitoring the two-way flow of physicians in South Africa
Authors: Tankwanchi Akhenaten Siankam , Hagopian Amy , Vermund Sten H 
Published: September 2019

IntroductionAlthough health labour migration is a global phenomenon, studies have neglected the flow of health workers into low-income and middle-income countries (LMICs). In compliance with the data-monitoring recommendation of the WHO Global Code of Practice on the International Recruitment of Health Personnel (Code), we estimated post-Code physician net migration (NM) in South Africa (SA), and SA’s net loss of physicians to Organisation for Economic Co-operation and Development (OECD) countries from 2010 to 2014.MethodsWe sourced data from the National Reporting Instrument reports, the OECD and the General Medical Council. Using the numbers of foreign nationals and international medical graduates (IMGs) registered in SA, and SA medical graduates registered in OECD countries (South African-trained international medical graduates (SA-IMGs)) as respective proxies for immigration and emigration, we estimated ‘NM’ as the difference between immigrant physicians and emigrant physicians and ‘net loss’ as the difference between OECD-trained IMGs and OECD-based SA-IMGs.ResultsIn 2010, SA hosted 8443 immigrant physicians, while OECD countries hosted 14 933 SA-IMGs, yielding a NM of −6490 physicians and a NM rate of −18% in SA. By 2014, SA-based immigrant physicians had increased by 4%, while SA-IMGs had decreased by −15%, halving the NM rate to −9%. SA-to-OECD estimated net loss of physicians dropped from −12 739 physicians in 2010 to −10 563 in 2014. IMGs represented 46% of 2010–2014 new registrations in SA, with the UK, Nigeria and the Democratic Republic of the Congo serving as leading sources. Registrants from conflict-scarred Libya increased >100-fold. More than 3400 SA-IMGs exited OECD-based workforces.ConclusionNM is a better measure of the brain drain than simply the emigration fraction. Strengthened health personnel data management and reporting through implementation of the Code-related system of National Health Workforce Accounts will further increase our understanding of health worker mobility in LMICs, with policymakers empowered to make more informed policies to address shortage.
Strengthening strategic management approaches to address antimicrobial resistance in global human health: a scoping review
Authors: Ahmad Raheelah , Zhu Nina Jiayue , Leather Andrew J M , Holmes Alison , Ferlie Ewan 
Published: September 2019

IntroductionThe development and implementation of national strategic plans is a critical component towards successfully addressing antimicrobial resistance (AMR). This study aimed to review the scope and analytical depth of situation analyses conducted to address AMR in human health to inform the development and implementation of national strategic plans.MethodsA systematic search of the literature was conducted to identify all studies since 2000, that have employed a situation analysis to address AMR. The included studies are analysed against frameworks for strategic analysis, primarily the PESTELI (Political, Economic, Sociological, Technological, Ecological, Legislative, Industry) framework, to understand the depth, scope and utility of current published approaches.Results10 studies were included in the final review ranging from single country (6) to regional-level multicountry studies (4). 8 studies carried out documentary review, and 3 of these also included stakeholder interviews. 2 studies were based on expert opinion with no data collection. No study employed the PESTELI framework. Most studies (9) included analysis of the political domain and 1 study included 6 domains of the framework. Technological and industry analyses is a notable gap. Facilitators and inhibitors within the political and legislative domains were the most frequently reported. No facilitators were reported in the economic or industry domains but featured inhibiting factors including: lack of ring-fenced funding for surveillance, perverse financial incentives, cost-shifting to patients; joint-stock drug company ownership complicating regulations.ConclusionThe PESTELI framework provides further opportunities to combat AMR using a systematic, strategic management approach, rather than a retrospective view. Future analysis of existing quantitative data with interviews of key strategic and operational stakeholders is needed to provide critical insights about where implementation efforts should be focussed, and also how to build contingency at the strategic level for agile responses to macro-level environmental influences.
Effects of oligosaccharide-sialic acid (OS) compound on maternal-newborn gut microbiome, glucose metabolism and systematic immunity in pregnancy: protocol for a randomised controlled study
Authors: Wang Shuxian , Peng Rui , Qin Shengtang , Liu Yu , Yang Huixia , Ma Jingmei 
Published: September 2019

IntroductionThe gut microbiota participates in multiple human biological processes, including metabolism and immune responses. During pregnancy, the dynamics of gut microbiota is involved in physiological adaptation. The disturbed profile of microbiome is associated with maternal complications, such as gestational diabetes mellitus (GDM), which further transfers to the offspring and influence their metabolic and immunological functions in the long term. Prebiotics targeting the gut microbiota and modulating metabolic and immune functions have been shown to be effective in non-pregnant populations with metabolic syndrome. Hence, we propose the use of a prebiotic supplement, oligosaccharide-sialic acid (OS) from the first trimester until delivery in pregnant women, can benefit maternal/new-born gut microbiome, glucose metabolism and innate immunity.Methods and analysisIn this prospective double-blinded randomised clinical trial, recruited singleton pregnancies will be stratified by body mass index (BMI) and randomly assigned to consume the OS preparation or placebo daily from the first trimester. At seven later time points (before and after recruitment in the first trimester, in the middle and third trimesters, before delivery, at birth and 42 days postpartum), compliance will be evaluated and/or biological samples will be collected. Along with maternal clinical information, questionnaires on lifestyle and infant development will be recorded. The primary outcomes are the effect of OS on the maternal-offspring gut microbiome and GDM incidence. The secondary outcomes are maternal glycolipid biochemical parameters, cytokine profiles, weight gain during pregnancy and infant morbidities, growth and development. The study aims to validate the effects of OS on reducing maternal morbidity within different BMI groups. The multiple dimensional dataset generated from the study includes clinical and lifestyle-related information, various biological markers and associated protective or risk factors for morbidity and prognosis. An extended follow-up through 42 days after birth could further explore the intrauterine influence on the long-term health of offspring.Ethics and disseminationThis protocol has been approved by Peking University First Hospital, National Unit of Clinical Trial Ethics Committee (reference number: 164). The results are expected to be published in scientific manuscripts by 2021.Trial registration numberChiCTR1800017192.
Dose–response relationship between physical activity and mortality in people with non-communicable diseases: a study protocol for the systematic review and meta-analysis of cohort studies
Authors: Geidl Wolfgang , Schlesinger Sabrina , Mino Eriselda , Miranda Lorena , Ryan Anna , Bartsch Katja , Janz Lukas , Pfeifer Klaus 
Published: September 2019

IntroductionThis study protocol outlines our planned systematic review and dose-response meta-analysis of postdiagnosis physical activity and mortality in people with non-communicable diseases (NCDs).Methods and analysisThis study is based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis for Protocols. A systematic literature search will be conducted in various databases—namely, PubMed, Scopus and Web of Science—by two researchers in order to identify prospective observational studies that investigate postdiagnosis physical activity or activity-related energy expenditure and mortality in individuals with NCDs. The target population is adults (≥18 years of age) with one of the following nine NCDs: low back pain, type 2 diabetes mellitus, osteoarthritis, depressive disorder, chronic obstructive pulmonary disease, breast cancer, lung cancer, stroke or ischaemic heart disease. We will focus on all-cause mortality as the primary outcome and investigate indication-specific mortality as the secondary outcome. For each study identified as a result of the literature search, we will conduct graphical dose-response analyses of mortality as a function of activity-related energy consumption. If more than two studies are available for one disease, we will perform linear and non-linear dose-response meta-analyses for said disease using random-effects models. We will investigate the heterogeneity of the studies and publication bias. To assess the risk of bias and the quality of the included studies, we will use the Risk Of Bias In Non-randomised Studies - of Interventions tool, which is a Cochrane tool.Ethics and disseminationThis systematic review will be conducted in compliance with ethical precepts. As the systematic review is based on published studies, approval from an ethics committee is not required. The systematic review and meta-analysis will be published in a peer-reviewed journal.PROSPERO registration numberCRD42018103357
Effects of heavy meson loops on higher charmonia radiative transitions
Authors: Qin Wen-Hua , An Chun-Sheng , Li Gang , Wang Chao , Wang Yan 
Published: September 2019

AbstractRadiative transitions between charmonium states offer an insight into the internal structure of heavy quark bound states within QCD. In this work, we performed a systematically investigation of the radiative transitions of$$\psi (nS) \rightarrow \gamma \chi _{cJ}(mP)$$ψ(nS)→γχcJ(mP)and$$\psi (nD) \rightarrow \gamma \chi _{cJ}(mP)$$ψ(nD)→γχcJ(mP)via intermediate charmed meson loop with a non-relativistic effective field theory. We only focus on the line-shape behavior of the distributions via different intermediate meson loops. Our results show that the coupled-channel effects of these decays are relatively weak, while the coupled channel effects has obvious enhancement when the inial (final) states are closed to the thresholds of charmed-mesons pair.
Explore with caution: mapping the evolution of scientific interest in physics
Authors: Aleta Alberto , Meloni Sandro , Perra Nicola , Moreno Yamir 
Published: September 2019

AbstractIn the bookThe Essential Tension (1979) Thomas Kuhn described the conflict between tradition and innovation in scientific research—i.e., the desire to explore new promising areas, counterposed to the need to capitalize on the work done in the past. While it is probable that along their careers many scientists felt this tension, only few works have tried to quantify it. Here, we address this question by analyzing a large-scale dataset, containing all the papers published by the American Physical Society (APS) in 26 years, which allows for a better understanding of scientists’ careers evolution in Physics. We employ the Physics and Astronomy Classification Scheme (PACS) present in each paper to map the scientific interests of 103,246 authors and their evolution along the years. Our results indeed confirm the existence of the “essential tension” with scientists balancing between exploring the boundaries of their area and exploiting previous work. In particular, we found that although the majority of physicists change the topics of their research, they stay within the same broader area thus exploring with caution new scientific endeavors. Furthermore, we quantify the flows of authors moving between different subfields and pinpoint which areas are more likely to attract or donate researchers to the other ones. Overall, our results depict a very distinctive portrait of the evolution of research interests in Physics and can help in designing specific policies for the future.
Improved strong-coupling perturbation theory of the symmetric Anderson impurity model
Authors: Ma Kou-Han , Tong Ning-Hua 
Published: September 2019

In a previous work [N. H. Tong, Phys. Rev. B 92 (2015) 165126], an equation-of-motion-based series expansion formalism was used to do the second-order strong-coupling expansion for the single-particle Green function of the Anderson impurity model (AIM). In this paper, we improve this theory in two aspects. We first use a more accurate scheme to self-consistently calculate the averages that appear in [Formula: see text]. In the resummation process, we use updated coefficients for the continued fraction (CF), guided by the formally exact CF from the Mori–Zwanzig theory. These changes lead to more accurate impurity spin responses to the magnetic bias of the bath. Combined with the dynamical mean-field theory, our theory gives improved description for the antiferromagnetism of Hubbard model at half-filling.
Nod2 deficiency functionally impairs adaptation to short bowel syndrome via alterations of the epithelial barrier function
Authors: Berlin Peggy , Reiner Johannes , Witte Maria , Wobar Jakob , Lindemann Sabeth , Barrantes Israel , Kreikemeyer Bernd , Bastian Manuela , Schäffler Holger , Bannert Karen , Jaster Robert , Lamprecht Georg 
Published: September 2019

Nucleotide-binding oligomerization domain-containing protein 2 ( NOD2) gene mutations are a risk factor for Crohn’s disease and also associated with worse outcome in short bowel syndrome (SBS) patients independent of the underlying disease. The aim of this study was to analyze the effect of Nod2 deficiency on barrier function and stool microbiome after extensive ileocecal resection in mice. Male C57BL6/J wild-type (WT) and Nod2-knockout (KO) mice underwent 40% ileocecal resection. Sham control mice received simple transection of the ileum. Clinical outcome was monitored daily. Barrier function was measured with Ussing chambers using FITC-4-kDa-Dextran flux, transmucosal electrical resistance, and dilution potentials. Immunofluorescence of claudin-2 was studied. Composition of the stool microbiome was assessed by 16S rRNA gene sequencing. Resected Nod2-KO mice had impaired clinical outcome compared with resected WT mice. This was accompanied by increased stool water contents and increased plasma aldosterone. Histomorphological adaptation was independent of Nod2. Barrier function studies revealed impaired sodium to chloride permeability and altered claudin-2 localization in the absence of Nod2. Resection induced decreases of bacterial diversity and a shift of bacteriodetes-to-firmicutes ratios. Ileum and cecum resection-induced increase in proteobacteria was absent in Nod2-deficient mice. Verrucomicrobia were temporarily increased in Nod2-KO mice. Nod2 deficiency functionally impairs adaptation to short bowel syndrome via a lesser increase of epithelial sodium pore permeability, altered epithelial barrier function, and the microbiome. NEW & NOTEWORTHY NOD2 gene mutations are associated with the development of severe short bowel syndrome and intestinal failure. The influence of Nod2 mutations on intestinal adaptation in experimental short bowel syndrome has not been studied yet. Here, we provide data that Nod2 deficiency worsens clinical outcome and functional adaptation under SBS conditions in mice, indicating that NOD2 is required for successful adaptation after ileocecal resection.
OATP1B3-1B7, a novel organic anion transporting polypeptide, is modulated by FXR ligands and transports bile acids
Authors: Malagnino Vanessa , Hussner Janine , Issa Ali , Midzic Angela , Meyer zu Schwabedissen Henriette E. 
Published: September 2019

Organic anion transporting polypeptide (OATP) 1B3–1B7 (LST-3TM12) is a member of the OATP1B [solute carrier organic anion transporter ( SLCO) 1B] family. This transporter is not only functional but also expressed in the membrane of the smooth endoplasmic reticulum of hepatocytes and enterocytes. OATP1B3–1B7 is a splice variant of SLCO1B3 in which the initial part is encoded by SLCO1B3, whereas the rest of the mRNA originates from the gene locus of SLCO1B7. In this study, we not only showed that SLCO1B3 and the mRNA encoding for OATP1B3–1B7 share the 5′ untranslated region but also that silencing of an initial SLCO1B3 exon lowered the amount of SLCO1B3 and of SLCO1B7 mRNA in Huh-7 cells. To validate the assumption that both transcripts are regulated by the same promoter we tested the influence of the bile acid sensor farnesoid X receptor (FXR) on their transcription. Treatment of Huh-7 and HepaRG cells with activators of this known regulator of OATP1B3 not only increased SLCO1B3 but also OATP1B3–1B7 mRNA transcription. Applying a heterologous expression system, we showed that several bile acids interact with OATP1B3–1B7 and that taurocholic acid and lithocholic acid are OATP1B3–1B7 substrates. As OATP1B3–1B7 is located in the smooth endoplasmic reticulum, it may grant access to metabolizing enzymes. In accordance are our findings showing that the OATP1B3–1B7 inhibitor bromsulphthalein significantly reduced uptake of bile acids into human liver microsomes. Taken together, we report that OATP1B3–1B7 transcription can be modulated with FXR agonists and antagonists and that OATP1B3–1B7 transports bile acids. NEW & NOTEWORTHY Our study on the transcriptional regulation of the novel organic anion transporting polypeptide (OATP) 1B3–1B7 concludes that the promoter of solute carrier organic anion transporter ( SLCO) 1B3 governs SLCO1B3–1B7 transcription. Moreover, the transcription of OATP1B3–1B7 can be modulated by farnesoid X receptor (FXR) agonists and antagonists. FXR is a major regulator in bile acid homeostasis that links OATP1B3–1B7 to this physiological function. Findings in transport studies with OATP1B3–1B7 suggest that this transporter interacts with the herein tested bile acids.
Automatic encoding of a target position relative to a natural scene
Authors: Nishimura Nobuyuki , Uchimura Motoaki , Kitazawa Shigeru 
Published: September 2019

We previously showed that the brain automatically represents a target position for reaching relative to a large square in the background. In the present study, we tested whether a natural scene with many complex details serves as an effective background for representing a target. In the first experiment, we used upright and inverted pictures of a natural scene. A shift of pictures significantly attenuated prism adaptation of reaching movements as long as they were upright. In one-third of participants, adaptation was almost completely cancelled whether the pictures were upright or inverted. It was remarkable that there were two distinct groups of participants, one who relies fully on the allocentric coordinate and the other who depended only when the scene was upright. In the second experiment, we examined how long it takes for a novel upright scene to serve as a background. A shift of the novel scene had no significant effects when it was presented for 500 ms before presenting a target, but significant effects were recovered when presented for 1,500 ms. These results show that a natural scene serves as a background against which a target is automatically represented once we spend 1,500 ms in the scene. NEW & NOTEWORTHY Prism adaptation of reaching was attenuated by a shift of natural scenes as long as they were upright. In one-third of participants, adaptation was fully canceled whether the scene was upright or inverted. When an upright scene was novel, it took 1,500 ms to prepare the scene for allocentric coding. These results show that a natural scene serves as a background against which a target is automatically represented once we spend 1,500 ms in the scene.
Retention and generalizability of balance recovery response adaptations from trip perturbations across the adult life span
Authors: König Matthias , Epro Gaspar , Seeley John , Potthast Wolfgang , Karamanidis Kiros 
Published: September 2019

For human locomotion, varying environments require adjustments of the motor system. We asked whether age affects gait balance recovery adaptation, its retention over months, and the transfer of adaptation to an untrained reactive balance task. Healthy adults (26 young, 27 middle-aged, and 25 older; average ages 24, 52, and 72 yr, respectively) completed two tasks. The primary task involved treadmill walking: either unperturbed (control; n = 39) or subject to unexpected trip perturbations (training; n = 39). A single trip perturbation was repeated after a 14-wk retention period. The secondary transfer task, before and after treadmill walking, involved sudden loss of balance in a lean-and-release protocol. For both tasks, the anteroposterior margin of stability (MoS) was calculated at foot touchdown. For the first (i.e., novel) trip, older adults required one more recovery step ( P = 0.03) to regain positive MoS compared with younger, but not middle-aged, adults. However, over several trip perturbations, all age groups increased their MoS for the first recovery step to a similar extent (up to 70%) and retained improvements over 14 wk, although a decay over time was found for older adults ( P = 0.002; middle-aged showing a tendency for decay: P = 0.076). Thus, although adaptability in reactive gait stability control remains effective across the adult life span, retention of adaptations over time appears diminished with aging. Despite these robust adaptations, the perturbation training group did not show superior improvements in the transfer task compared with age-matched controls (no differences in MoS changes), suggesting that generalizability of acquired fall-resisting skills from gait-perturbation training may be limited. NEW & NOTEWORTHY The human neuromotor system preserves its adaptability across the adult life span. However, although adaptability in reactive gait stability control remains effective as age increases, retention of recovery response adaptations over time appears to be reduced with aging. Furthermore, acquired fall-resisting skills from single-session perturbation training seem task specific, which may limit the generalizability of such training to the variety of real-life falls.
ZEB1 Collaborates with ELK3 to Repress E-Cadherin Expression in Triple-Negative Breast Cancer Cells
Authors: Cho Hyeon-Ju , Oh Nuri , Park Ji-Hoon , Kim Kwang-Soo , Kim Hyung-Keun , Lee Eunbyeol , Hwang Sohyun , Kim Seong-Jin , Park Kyung-Soon 
Published: September 2019

Abstract

ZEB1 has intrinsic oncogenic functions that control the epithelial-to-mesenchymal transition (EMT) of cancer cells, impacting tumorigenesis from its earliest stages. By integrating microenvironment signals and being implicated in feedback regulatory loops, ZEB1 appears to be a central switch that determines EMT and metastasis of cancer cells. Here, we found that ZEB1 collaborates with ELK3, a ternary complex factor belonging to the ETS family, to repress E-cadherin expression. ZEB1 functions as a transcriptional activator of ELK3. We first identified that ELK3 and ZEB1 have a positively correlated expression in breast cancer cells by using multiple databases for correlation analysis. Molecular analysis revealed that ZEB1 functions as a transcriptional activator of ELK3 expression. GST pull-down assay and coimmunoprecipitation analysis of wild-type or domain deletion mutants of ZEB1 and ELK3 showed that these 2 proteins directly bound each other. Furthermore, we demonstrated that ZEB1 and ELK3 collaborate to repress the expression of E-cadherin, a representative protein that initiates EMT. Our finding suggested that ELK3 is a novel factor of the ZEB1/E-cadherin axis in triple-negative breast cancer cells.

Implications:
ELK3 is a novel factor in the ZEB1/E-cadherin axis and ZEB1 has a dual role in ELK3 as a transcriptional activator and as a collaborator to repress E-cadherin expression in triple-negative breast cancer cells.