bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and radiologic outcomes following resection of primary proximal fibula tumors: Proximal fibula resection outcomes
Authors: Arikan Yavuz , Misir Abdulhamit , Gur Volkan , Kizkapan Turan Bilge , Dincel Yasar Mahsut , Akman Yunus Emre 
Published: March 2019

Purpose: Reconstruction of the lateral collateral ligament (LCL) and biceps femoris tendon following proximal fibula resection is controversial. Postoperative knee instability and peroneal nerve dysfunction affect outcome. This study aimed to determine functional, clinical, and radiological outcomes of patients who underwent en bloc proximal fibula resections and to compare clinical and radiological instability rates for primary repair after type I and type II resections. Materials and Methods: Eleven patients with primary tumors of the proximal fibula were included. Musculoskeletal Tumor Society (MSTS) score and Lysholm knee score were used in the evaluation of functional outcomes. Clinical outcome was assessed using knee range of motion and knee varus stress test. Radiological outcome was assessed using varus stress knee radiographs. Knee stability was evaluated using the varus stress test at 30° of knee flexion and varus stress knee radiographs and graded in millimeters. Results: Of the 11 tumors, 6 (54.6%) underwent type I resection. In five (45.4%) patients, type II resection was performed. The mean follow-up period was 32 ± 13.9 months (range, 12–55 months; median, 27 months). The mean knee joint lateral opening, MSTS score, and Lysholm knee score with type I versus type II resection were 5.7 ± 1.2 mm versus 6.4 ± 1.1 mm ( p = 0.247), 28.7 ± 1.8 (95.6%) versus 20.4 ± 7.7 (68%) ( p = 0.011), and 92.2 ± 8.8 versus 62.8 ± 20.4 ( p = 0.026), respectively. Postoperative complications of all patients included one (9.1%) deep tissue infection and one (9.1%) long-term knee instability. In one patient (9.1%) who underwent type II resection, above-the-knee amputation was performed after local recurrence. Conclusions: Primary repair of the LCL and biceps femoris tendon to the surrounding soft tissues after resection of proximal fibular tumors provides good clinical outcomes. Primary repair is a simple technique to perform with minimal morbidity. Peroneal nerve palsy was a problem, especially in type II resections. Level of Evidence: Therapeutic Level III.
Surgical treatment of anterior cervical osteophytes causing dysphagia
Authors: Ruetten Sebastian , Baraliakos Xenophon , Godolias Georgios , Komp Martin 
Published: March 2019

Purpose: Dysphagia due to anterior cervical osteophytes is a rare condition. However, it can become serious enough to permanently impair the quality of life up to making normal food intake impossible. If conservative treatment fails, there is the option of surgical resection of the osteophytes. The objective of this study was to assess the outcomes of resections of anterior cervical osteophytes causing spondylogenic dysphagia, taking literature into consideration. Method: Resection of anterior cervical osteophytes using a standard anterior approach was performed in 14 consecutive patients with spondylogenic dysphagia between 2009 and 2015. Indomethacin or radiation was used to prevent recurrence. Imaging and clinical data were collected in follow-up examinations over an average of 50 months. Results: The osteophytes were sufficiently resected in all cases. Anterior plates were placed in three patients due to pronounced segmental mobility. Five patients were given recurrence prevention in the form of indomethacin, nine with radiation. One patient required revision surgery for a hematoma. No other serious complications were observed. All patients had significant improvement of their symptoms. No recurrences or signs of increasing instability were found during the follow-up period. Conclusion: When conservative treatment fails, surgical resection of cervical osteophytes is a sufficient method for treating spondylogenic dysphagia. High patient satisfaction and improvement of the quality of life are achieved with a low complication rate. Routine additional stabilization has been discussed as recurrence prevention. Prophylaxis using indomethacin or radiation, known primarily from hip replacement, also appears to be an option.
Design of Temperature-Responsive Polymer-Grafted Surfaces for Cell Sheet Preparation and Manipulation
Authors: Kobayashi Jun , Okano Teruo 
Published: March 2019

Abstract
This review focuses on the design of poly(N-isopropylacrylamide) (PIPAAm)-grafted surfaces for cell sheet preparation and manipulation, which are revolutionary tools for the creation of transplantable two-dimensional (2D) and engineered three-dimensional (3D) cellular tissues. Particularly, the thickness of grafted PIPPAm chains in the perpendicular direction is regulated to achieve temperature-dependent alteration of cell sheet preparation/harvesting. The 2D positioning of grafted PIPAAm in a direction parallel to the material surfaces facilitates spatially controlled micropatterns containing heterotypic cells. This review also describes the 2D manipulation of cell sheets and the creation of cell sheet-layered 3D tissue using the PIPAAm-grafted surface. With the aid of supporting materials such as membranes and gelatin hydrogels, cell sheets on PIPAAm-grafted surfaces can be manipulated and applied for transplantation in clinical settings and for the formation of 3D tissues in vitro. For the next generation of cell sheet-based tissue engineering, a challenging issue is the creation of large, thick tissues/organs such as cardiac and hepatic tissues/organs. The integration of various technologies including bioreactors and micropatterning is essential to achieve the creation of functional engineered 3D organs.
Method validation to assess in vivo cellular and subcellular changes in buccal mucosa cells and saliva following CBCT examinations
Authors: Belmans Niels , Gilles Liese , Virag Piroska , Hedesiu Mihaela , Salmon Benjamin , Baatout Sarah , Lucas Stéphane , Jacobs Reinhilde , Lambrichts Ivo , Moreels Marjan 
Published: March 2019

Objectives:Cone-beam CT (CBCT) is a medical imaging technique used in dental medicine. However, there are no conclusive data available indicating that exposure to X-ray doses used by CBCT are harmless. We aim, for the first time, to characterize the potential age-dependent cellular and subcellular effects related to exposure to CBCT imaging. Current objective is to describe and validate the protocol for characterization of cellular and subcellular changes after diagnostic CBCT.Methods:Development and validation of a dedicated two-part protocol: 1) assessing DNA double strand breaks (DSBs) in buccal mucosal (BM) cells and 2) oxidative stress measurements in saliva samples. BM cells and saliva samples are collected prior to and 0.5 h after CBCT examination. BM cells are also collected 24 h after CBCT examination. DNA DSBs are monitored in BM cells via immunocytochemical staining for γH2AX and 53BP1. 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxo-dG) and total antioxidant capacity are measured in saliva to assess oxidative damage.Results:Validation experiments show that sufficient BM cells are collected (97.1 ± 1.4 %) and that γH2AX/53BP1 foci can be detected before and after CBCT examination. Collection and analysis of saliva samples, either sham exposed or exposed to IR, show that changes in 8-oxo-dG and total antioxidant capacity can be detected in saliva samples after CBCT examination.Conclusion:The DIMITRA Research Group presents a two-part protocol to analyze potential age-related biological differences following CBCT examinations. This protocol was validated for collecting BM cells and saliva and for analyzing these samples for DNA DSBs and oxidative stress markers, respectively.
Are we missing ‘previously treated’ smear-positive pulmonary tuberculosis under programme settings in India? A cross-sectional study
Authors: Shewade Hemant Deepak , Gupta Vivek , Satyanarayana Srinath , Kharate Atul , Murali Lakshmi , Deshpande Madhav , Kumar Naresh , Pandey Prabhat , Bajpai U N , Tripathy Jaya Prasad , Kathirvel Soundappan , Pandurangan Sripriya , Mohanty Subrat , Ghule Vaibhav Haribhau , Sagili Karuna D , Prasad Banuru Muralidhara , Nath Sudhi , Singh Priyanka , Singh Kamlesh , Jayaraman Gurukartick , Rajeswaran P , Srivastava Binod Kumar , Biswas Moumita , Mallick Gayadhar , Bera Om Prakash , Jaisingh A James Jeyakumar , Naqvi Ali Jafar , Verma Prafulla , Ansari Mohammed Salauddin , Mishra Prafulla C , Sumesh G , Barik Sanjeeb , Mathew Vijesh , Lohar Manas Ranjan Singh , Gaurkhede Chandrashekhar S , Parate Ganesh , Bale Sharifa Yasin , Koli Ishwar , Bharadwaj Ashwin Kumar , Venkatraman G , Sathiyanarayanan K , Lal Jinesh , Sharma Ashwini Kumar , Kumar Ajay MV , Chadha Sarabjit S 
Published: March 2019

Background: In 2007, a field observation from India reported 11% misclassification among ‘new’ patients registered under the revised national tuberculosis (TB) control programme. Ten years down the line, it is important to know what proportion of newly registered patients has a past history of TB treatment. Methods: A study was conducted among new smear-positive pulmonary TB patients registered between March 2016 and February 2017 in 18 randomly selected districts to determine the effectiveness of an active case-finding strategy in marginalised and vulnerable populations. We included all patients detected through active case-finding. An equal number of randomly selected patients registered through passive case-finding from marginalised and vulnerable populations in the same districts were included. Before enrolment, we enquired about any history of previous TB treatment through interviews. Results: Of 629 patients, we interviewed 521, of whom, 11% (n=56) had past history of TB treatment (public or private) for at least a month: 13% (34/268) among the active case-finding group and 9% (22/253) among the passive case-finding group (p=0.18). No factors were found to be significantly associated with misclassification. Conclusion: Around one in every ten patients registered as ‘new’ had previous history of TB treatment. Corrective measures need to be implemented, followed by monitoring of any change in the proportion of ‘previously treated’ patients among all registered patients treated under the programme at national level.
A vulnerable generation? Youth agency facing work precariousness
Authors: Rebughini Paola 
Published: March 2019

Agencia y vulnerabilidad no son términos alternativos; al contrario, su encuentro hace emerger una característica distintiva de la agencia: la del “débil” que se enfrenta con dificultad a las restricciones y que descubre nuevas oportunidades. Tras una discusión teórica en torno a la relación entre agencia y vulnerabilidad y de las transformaciones de los procesos de subjetivación, este artículo se centra en la situación específica de vulnerabilidad en el mercado de trabajo que vive la actual generación de jóvenes. El texto analiza, apoyándose en una investigación realizada en Italia entre 2013 y 2017, los límites y potencialidades de la agencia de los jóvenes como una obligación en un contexto de precariedad en el trabajo. El objetivo es recalcar cómo agencia y vulnerabilidad —más que ser características intrínsecas del individuo— han de entenderse en relación con posiciones temporales, en la intersección de categorías y recursos, en condiciones situadas y relacionales.
Noninvasive Diagnosis of Irritable Bowel Syndrome via Bowel Sound Features: Proof of Concept
Authors: Du Xuhao , Allwood Gary , Webberley K. Mary , Inderjeeth Andrisha-Jade , Osseiran Adam , Marshall Barry James 
Published: March 2019

INTRODUCTION:
Irritable bowel syndrome (IBS) is a common and debilitating disorder estimated to affect approximately 11% of the world's population. Typically, IBS is a diagnosis of exclusion after patients undergo a costly and invasive colonoscopy to exclude organic disease. Clinician's and researchers have identified a need for a new cost-effective, accurate, and noninvasive diagnostic test for IBS.

METHODS:
Using a diagnostic case-control study, we explored the use of bowel sounds to characterize IBS with a view to diagnostic use. We recruited participants with an existing clinical diagnosis of IBS or healthy (asymptomatic) digestive systems. We recorded bowel sounds for 2 hours after fasting and then for 40 minutes after a standard meal.

RESULTS:
We here report our results including our accuracy in characterizing IBS-related bowel sounds and differentiation between participants with IBS and healthy participants. Leave-one-out cross-validation of our model developed using the first 31 IBS and 37 healthy participants gave 90% sensitivity and 92% specificity for IBS diagnosis. Independent testing using the next 15 IBS and 15 healthy participants demonstrated 87% sensitivity and 87% specificity for IBS diagnosis.

CONCLUSIONS:
These preliminary results provide proof of concept for the use of bowel sound analysis to identify IBS. A prospective study is needed to confirm these findings.

TRANSLATIONAL IMPACT:
Our belt and model offer hope of a new approach for IBS diagnosis in primary practice. Combined with screening tests for organic disease, it would offer greater confidence to patients and could reduce the burden of unnecessary colonoscopies for health care systems and patients.
The effect of addition selected amino acids in extender semen on quality and DNA stability of frozen-thawed Sumba Ongole bull spermatozoa
Authors: Said Syahruddin , Setiorini Setiorini , Adella Amaitshaa , Sari Indah , Fathaniah Nursafira , Maulana Tulus 
Published: March 2019

<p class="abstrak1"><span lang="IN">The objective of the current study was to asses the optimal concentration of glutamine, glycine and cysteine amino acids in tris-citric-acid-fructose egg yolks (TCFY) extender on quality of SO bull spermatozoa during freezing and thawing. </span><span lang="EN-US">In t</span><span lang="IN">his study the DNA stability of frozen-thawed Sperm</span><span lang="EN-US"> was </span><span lang="IN">also indentified. Three mature bulls maintained at PT. Karya Anugerah Rumpin, private cattle breeding company, West Java, Indonesia were used as semen donors. Semen was collected using artificial vagina and were evaluated </span><span lang="EN-US">prior</span><span lang="IN"> to freezing. Semen was diluted with TCFY supplemented with different concentrations of amino acids (5, 15 and 25 mM glycine and glutamine, and 3, 5 and 7 mM cysteine) then processed for colling and freezing. Semen quality parameters (subjective motility, viability and membrane and DNA integrity). </span><span lang="EN-US">D</span><span lang="IN">ata showed that in general the effect of addition of selected amino acids (glycine, glutamine and cysteine) </span><span lang="EN-US">in</span><span lang="IN">to TCFY extenders on motility, viability and membrane integrity of SO spermatozoa after cooling were significantly different (p&lt;0.05) higher than</span><span lang="EN-US"> that of</span><span lang="IN"> control. Addition of 15 mM glycine, 15 mM glutamine and 5 mM cysteine resulted in significant (p&lt;0.05) increase post-thawing sperm motility and sperm viability as compared to th</span><span lang="EN-US">at of</span><span lang="IN"> control. Furthermore, when spermatozoa were stained with acridine orange after fixation with acetic alcohol, the DNA integrity of post-thawing spermatozoa showed that all spermatozoa were remain intact. In conclusion </span><span lang="EN-US">,</span><span lang="IN">addition of 15 mM glycine, glutamine and 5 mM cysteine increase the cryoprotecting efficacy of bovine bull cryopreservation extender, and furthermore all DNA spermatozoa were remain intact. </span></p>
İLKÖĞRETİM KURUMLARINDA ÇALIŞAN ÖĞRETMENLERİN DERS DENETİMİNE İLİŞKİN KAYGI DÜZEYLERİ
Authors: KARASU Yasin , CÖMERT Melike 
Published: March 2019

Bu araştırmanın
amacı ilköğretim okullarında görev yapan sınıf ve branş öğretmenlerinin kurum
yöneticisi tarafından yapılan ders denetimi sırasında yaşamış oldukları kaygı
düzeylerini belirlemektir. Araştırma nicel bir araştırma olup tarama modeli
kullanılmıştır. Veri toplama aracı olarak Karakaya ve diğerleri(2011) tarafından
geliştirilen “Denetim
Kaygısı Ölçeği” kullanılmış olup toplanan veriler SPSS-23 programı ile analiz
edilmiştir. Verilerin analizinde Kruskal Wallis ve Mann
Whitney U analizleri yapılmıştır. Araştırmanın Evrenini 2018-2019
Eğitim-Öğretim yılında Adıyaman İli Merkez ilçede görev yapan ilkokul ve
ortaokul öğretmenleri oluşturmaktadır. Araştırmanın örneklemi, tabakalı
örnekleme yöntemi ile seçilmiş olup 82 sınıf ve 182 branş öğretmeninden
oluşmaktadır. Elde edilen bulgulara göre, öğretmenler denetim sırasında genel
olarak orta düzeyde kaygı yaşamakta olup,
kadın öğretmenlerin yaşadığı denetim kaygısı düzeyi erkek öğretmenlerin
yaşadığı denetim kaygısı düzeyinden daha fazladır. Ayrıca kaygı düzeyleri
medeni durum ve branş değişkenlerine göre ölçeğin alt boyutları açısından
farklılık göstermektedir.
TÜRKİYE’DEKİ KATILIM BANKALARININ FİNANSAL ETKİNLİKLERİNİN KARŞILAŞTIRILMASI ÜZERİNE BİR ARAŞTIRMA
Authors: BOLAT İsmet , METİN Mehmet 
Published: March 2019

Türkiye’de ilk olarak özel finans
kurumları olarak kurulan ve özellikle 1980’li yıllardan sonra Ortadoğu’dan
gelen fonlarla daha fazla gelişme gösteren özel finans sektöründe bankacılık
faaliyetleri yürüten kuruluşlara 2005 yılında katılım bankaları adı
verilmiştir. Faizsiz finans prensibine bağlı çalışan katılım bankaları dini inanışları
nedeniyle sistem dışında kalan tasarruf sahiplerinin kaynaklarının ekonomik
sisteme kazandırılmasında önemli bir rol oynamıştır. Çalışmada, Türkiye’deki
aktif olan katılım bankalarından 5’i için 2016-2017 yılları arası veriler
kullanılmıştır. Bu veriler Veri Zarflama Analizi (VZA) kullanılarak analiz
edilmiştir. Analizde, veriler BCC- CCR yöntemlerine göre girdi ve çıktı odaklı
olarak yorumlanmıştır. Ayrıca statik olan VZA ‘ya dinamik bir boyut kazandırmak
için iki yılın karşılaştırmasını yapan Malmquist verimlilik endeksinden de
yararlanılmıştır. Türkiye’deki 5 katılım bankası arasında yapılan analizler
sonucunda Kuveyt Türk Katılım Bankası 2 yılda da 2 yönteme göre de etkin banka
olarak bulunmuştur. Diğer bankaların etkinlik değerleri yıllar itibariyle farklılık göstermektedir.
İŞLETME DÜZEYİNDE ÇEVRE MUHASEBESİ: BİR UYGULAMA
Authors: OKUTMUŞ Ercüment 
Published: March 2019

20. yüzyılın son çeyreğinden itibaren
kitle iletişimi, ulaşım ve üretim alanlarında görülen teknolojik gelişmeler,
insanoğlunun refahının artmasını sağlayan bir ortam oluşturmakla birlikte nüfusun
aşırı artışı üretimin boyutlarını değiştirmiş dolayısı ile üretim sonucu oluşan
zararlı atıklar kirlilik etkisi oluşturmuştur. Bu etki özellikle son yıllarda
dünyanın ekolojik dengesini bozacak boyutlara ulaşmıştır. Dolayısıyla işletmeler
çevresel faktörlere dikkat ederek üretimlerini devam ettirirken normal üretim
maliyetleri ile birlikte çevre odaklı önleme kullanma ve zarar gibi birtakım ek
maliyetlere de katlanmaları gerekmektedir. Konunun önemi gereği çevresel
maliyetlerin işletme düzeyinde tekdüzen muhasebe sistemine entegrasyonu ile
ilgili çalışmalar son dönemlerde literatüre yeni girmeye başlamıştır. Özellikle
tekdüzen muhasebe sisteminde çevre maliyetlerinin muhasebe sistemi içinde nasıl
yer alacağı, nasıl sınıflanacağı, üretim maliyetlerine nasıl yükleneceği
hususları araştırmacılar ve uygulamacılar için önem arz etmektedir. Bu çalışmada çevre maliyetleri kısaca
tanıtılarak çevre maliyetlerinin muhasebe sisteminde nasıl yer alması gerektiği
ve nasıl muhasebeleştirildiği anlatılmıştır. Çalışmanın uygulaması, kurşun,
sülfürik asit ve plastik gibi çevre kirliliği unsurlarını yoğun olarak içeren
bir sektör olan akümülatör sektöründen TO-RO-NA Endüstri Limited Şirketi’nde
yapılmıştır. İşletmede çevre maliyetleriyle ilgili bir tasnif işlemi yapılarak
işletmenin gerçek değerleri ile çevre maliyetleri muhasebeleştirilmiştir. Genel
üretim giderleri dağıtılırken çevre gider yeri açılması ile dağıtımlar tamamlandığında
işletmenin genel üretim giderleri kapsamında ne kadar çevresel maliyete
katlandığı tespit edilmiş olur. Genel üretim giderleri, dağıtım öncesi genel
üretim giderleri olarak gider çeşitlerine göre klasik olarak
muhasebeleştirilir.
Scaling-up in-memory datalog processing
Authors: Fan Zhiwei , Zhu Jianqiao , Zhang Zuyu , Albarghouthi Aws , Koutris Paraschos , Patel Jignesh M. 
Published: March 2019

Recursive query processing has experienced a recent resurgence, as a result of its use in many modern application domains, including data integration, graph analytics, security, program analysis, networking and decision making. Due to the large volumes of data being processed, several research efforts across multiple communities have explored how to scale up recursive queries, typically expressed in Datalog. Our experience with these tools indicate that their performance does not translate across domains---e.g., a tool designed for large-scale graph analytics does not exhibit the same performance on program-analysis tasks, and vice versa.
Starting from the above observation, we make the following two contributions. First, we perform a detailed experimental evaluation comparing a number of state-of-the-art Datalog systems on a wide spectrum of graph analytics and program-analysis tasks, and summarize the pros and cons of existing techniques. Second, we design and implement our own general-purpose Datalog engine, called RecStep, on top of a parallel single-node relational system. We outline the techniques we applied on RecStep, as well as the contribution of each technique to the overall performance. Using RecStep as a baseline, we demonstrate that it generally out-performs state-of-the-art parallel Datalog engines on complex and large-scale Datalog evaluation, by a 4-6X margin. An additional insight from our work is that it is possible to build a high-performance Datalog system on top of a relational engine, an idea that has been dismissed in past work.
Endometriosis and the menopause: why the question merits our full attention
Authors: Marie-Scemama Lydia , Even Marc , De La Joliniere Jean Bouquet , Ayoubi Jean-Marc 
Published: March 2019

Abstract
As an estrogen-dependent disease, endometriosis was thought to become less active or regress with the onset of the menopause. However, based on some new data, we are discovering that this pathology can emerge or reappear at this period of life. Clinicians must consider it as a possible cause for cases of pelvic pain, and heavy bleeding. Authors have described a possibility of transformation of the intraperitoneal proliferation into a malignant type with ovarian, bowel and even lung metastasis. The risk of transformation into an ovarian cancer is around 2 or 3%. The role of menopausal hormonal therapy will be discussed as in recurrence in the case of residue existence, especially after incomplete surgery. Is it possible to prescribe hormonal therapy to a menopausal women suffering climacteric symptoms as it could trigger a recurrence of endometriosis and even an increased risk of malignant degeneration? This remains unclear. It is an unresolved therapeutic dilemma; the choice between surgery or medical treatment?
Crystal structure of 1,1′-(hexane-1,6-diyl)bis(3-ethyl-1H-imidazol-3-ium) bis(hexafluorido phosphate), C16H28F12N4P2
Authors: Wen Zhao , Jing Chen , Wan-Ming Xiong , Ying-Dong Lan , Xu-Liang Nie 
Published: March 2019

Abstract
C16H28N4 2(F6P), monoclinic, P21/n (no. 14), a = 8.7921(12) Å, b = 16.173(2) Å, c = 9.1376(12) Å, β = 111.13(10)°, V = 1211.1(3) Å3, Z = 2, R
gt(F) = 0.0475, wR
ref(F
2) = 0.1262, T = 296(2) K.
The crystal structure of poly[m2-aqua-tetraaqua-bis(m9-4-formylbenzene-1,3-disulfonato)tetrasodium(I) hydrate, C14H18O19S4Na4
Authors: Xi-Shi Tai , Li-Li Liu , Xiao-Jing Zhou 
Published: March 2019

Abstract
C14H18O19S4Na4, triclinic, P1̄ (no. 2), a = 7.0769(14) Å, b = 9.5622(19) Å, c = 10.952(2)) Å, α = 115.14(3)°, β = 90.46(3)°, γ = 106.53(3)°, V = 636.1(2) Å3, Z = 1, R
gt(F) = 0.0448, wR
ref(F
2) = 0.1191, T = 293(2) K.