bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatores preditivos associados ao êxito na cirurgia de varicocele para a infertilidade
Authors: Bernardo Rogério César Correia , Medeiros Mércia Lamenha , Machado Aydano Pamponet , Oliveira Michelle Jacintha Cavalcante , Bernardo Thaís Honório Lins 
Published: October 2024

Objetivo: Identificar na literatura científica fatores preditivos associados ao êxito na cirurgia de varicocele para infertilidade. Métodos: Revisão integrativa, com artigos publicados entre 2019 a 2023, nos idiomas português, inglês e espanhol e texto completo disponível. Utilizou-se como questão norteadora: Quais são os fatores preditivos associados ao êxito na cirurgia de varicocele para a infertilidade? A pesquisa bibliográfica foi realizada em novembro de 2023 nas bases de dados: Pubmed, Biblioteca Virtual em Saúde, Scielo e Science Direct, por meio dos Descritores em Ciências da Saúde: Varicocele, Infertilidade, Inteligência Artificial e preditores, realizando combinações com os termos com o uso do operador booleano “AND”. Resultados: 27 artigos obedeceram aos critérios de inclusão e exclusão, nos quais 06 artigos na Science Direct, 14 na Pubmed, e 07 na Biblioteca Virtual em Saúde. Em relação ao tipo de estudo, 9 foram coorte, 6 de revisão, 2 prospectivos, 3 retrospectivos, 2 ensaios clínicos, 3 de intervenção, 1 experimental e 2 observacionais. Considerações finais: Considera-se que alguns fatores podem ser preditores de êxito na cirurgia de varicocele. Entre eles estão parâmetros hormonais, presença de refluxo ao ultrassom, técnica cirúrgica e aspectos no espermograma pré-operatório, normogramas, aprendizagem de máquina e modelagem foram alguns métodos utilizados pelos autores.
A unique case of Sylvian arachnoid cyst complicated by chronic subdural hematoma
Authors: Asagiri Hana , Tsutsumi Satoshi , Izumi Hiroshi , Inami Kasumi , Yamataka Motoki , Sugiyama Natsuki , Ueno Hideaki , Ishii Hisato 
Published: October 2024

Background:
Arachnoid cysts (ACs) complicated by chronic subdural hematoma (CSDH) are a rare but distinct entity.

Case Description:
A 27-year-old man previously diagnosed with Sylvian AC presented to the hospital with a persistent headache. He was not aware of any preceding head trauma. However, he frequently performed bench presses at the gymnasium, especially 4 weeks prior. The patient did not exhibit any neurological deficits at presentation. Computed tomography revealed slightly low-density areas in the right cerebral convexity. Magnetic resonance imaging revealed compressive masses in the right middle fossa and cerebral convexity. The patient underwent a craniotomy. Reflection of the dura mater exposed thickened arachnoid membrane. Making an incision resulted in the egress of fluid hematoma. The membrane separating the subdural hematoma and inner AC possessed fine vasculature and adjacent holes. Furthermore, there were fragile clots adhered to the inner wall of the cyst. Microscopic findings of the separating membrane were consistent with inflammatory granulation tissue, similar to those of the outer membrane of CSDH.

Conclusion:
Exertional hypertension associated with the bench press may result in the rupture of fine arteries distributed over the AC wall. Under certain circumstances, the AC wall may transform into the outer membrane of CSDH.
Динамика биохимических показателей при моделировании неалкогольной жировой болезни печени различной степени тяжести
Authors: Т.В. Брус , А.Г. Васильев 
Published: October 2024

Целью данного исследования было выявить специфические биохимические показатели для верификации степени тяжести неалкогольной жировой болезни печени. Материалы и методы. В эксперименте использовал два варианта модели неалкогольной жировой болезни печени: лёгкий – неалкогольный стеатоз, и тяжёлый вариант – неалкогольный стеатогепатит. Измеряли следующие биохимические показатели: активность ферментов аспартатаминотрансферазы (АСТ), аланинаминотрансферазы (АЛТ), щелочной фосфатазы (ЩФ), лактатдегидрогеназы (ЛДГ), концентрации глюкозы, общего билирубина (ОБил) и его прямой фракции (ПБ), общего белка (ОБ), концентрации гомоцистеина, триацилглицеридов (ТГ), общего холестерина (ОХ), супероксиддисмутазы (СОД), каталазы (Кат) и малонового диальдегида (МДА). Результаты. Степень тяжести развившихся стеатоза и стеатогепатита в экспериментальных группах была напрямую связана со способом моделирования неалкогольной жировой болезни печени. На модели стеатогепатита дисфункция печени была выражена в большей степени, чем в модели стеатоз; это различие проявлялось в более выраженном повышении АСТ, АЛТ, ЩФ, Обил, ОХ, МДА (p < 0,001) и снижении СОД, Кат (p < 0,05). Заключение. Исследование продемонстрировало целесообразность определения биохимических маркеров, в том числе уровней АЛТ, АСТ, ОБил, ТГ, МДА и СОД для оптимизации методологии лабораторной диагностики степени тяжести жировой дистрофии печени.
The aim of this study was to identify biochemical markers to determine the severity of non-alcoholic fatty liver disease. Materials and methods. In the experiment, we used two variants of the non-alcoholic fatty liver disease model: a mild one – non-alcoholic steatosis and a severe variant – non-alcoholic steatohepatitis. The following biochemical parameters were measured: enzyme activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), plasma glucose concentration, total protein (TP), total bilirubin (TBil) and its direct fraction (DF), plasma concentrations of homocysteine, total cholesterol (TC), triacylglycerides (TG), catalase (Cat), superoxide dismutase (SOD) and malondialdehyde (MDA). Results. The severity of developing steatosis and steatohepatitis in the experimental groups was directly related to the way nonalcoholic fatty liver disease was modeled. In the model of steatohepatitis, liver function was impaired to a much greater extent than with steatosis; this difference was manifested in a statistically significant increase in ALT, AST, ALP, TC, Obil, MDA (p<0.001) and a decrease in Cat, SOD (p<0.05). Conclusion. The study demonstrated the feasibility of determining biochemical markers, including the levels of ALT, AST, OBil, TG, MDA and SOD to optimize the methodology for laboratory diagnosis of the severity of fatty liver disease.
Физиологические механизмы и психологические факторы развития стресс-реакции у спортсменов высокой квалификации, занимающихся танцевальным спортом
Authors: И.Д. Коняев , Н.Н. Захарьева 
Published: October 2024

Представлен обзор современной отечественной и зарубежной литературы, посвященной проблематике возникновения и проявления негативных стресс-реакций у спортсменов высокой квалификации, занимающихся танцевальным спортом. Продемонстрировано, что психологический стресс и психоэмоциональное напряжение у танцоров могут быть вызваны различными факторами, включая соревновательный стресс и организационный стресс, а также зависят от личных индивидуально-типологических качеств спортсмена. Развитию нервно-психического напряжения у спортсменов-танцоров может способствовать отсутствие финансовых средств и негативное воздействие «межличностных стрессоров». Исследования показывают, что танцоры-мужчины могут подвергаться насмешкам и оскорблениям из-за принадлежности к танцевальному спорту чаще, чем мужчины, занимающиеся другими видами спорта. Поскольку психоэмоциональное состояние одного партнера отражается на другом, то перспективным направлением является разработка копинг-стратегий и рекреационных программ для снижения высокого уровня тревожности и симптомов нервно-психического напряжения у спортсменов-танцоров.
This article presents an overview of modern domestic and foreign literature on the problems of the occurrence and manifestation of negative stress reactions of athletes-dancers. According to literary sources, it has been established that psychological stress and psycho-emotional tension in dancers can be caused by various factors, including competitive stress, organizational stress, and depend on the personal individual typological qualities of the athlete. The lack of financial resources and the negative impact of “interpersonal stressors” can contribute to the development of neuropsychic stress in athletes-dancers. Research shows that male dancers may be subjected to ridicule and insults because of their membership in dance sports more often than men involved in other sports. Since the psychoemotional state of one partner affects the other, a promising direction is the development of coping strategies and recreational programs to reduce anxiety and symptoms of neuropsychiatric stress in athletes-dancers.
Особенности ориентировочно-исследовательского поведения крыс при остеоартрите височно-нижнечелюстного сустава
Authors: А.В. Клименко , О.С. Романенко , Д.А. Черемисова , И.В. Алексеева , С.С. Перцов 
Published: October 2024

Цель исследования: изучение ориентировочно-исследовательского поведения самок крыс в динамике наблюдений в тесте «открытое поле» на модели боли в челюстно-лицевой области. Материалы и методы: Исследование проведено на 18 самках крыс Wistar. Остеоартрит височно-нижнечелюстного сустава вызван внутрисуставным введением моноиодацетата натрия. Показатели поведения регистрировали в тесте «открытое поле» (ОП). Измерения проводили в исходном состоянии и через 14 дней после введения реагентов. Результаты. Показано, что самки крыс с болевым синдромом характеризуются снижением количества перемещений по периферическим секторам и увеличением времени груминга. К окончанию наблюдений латентный период первого движения в тесте «открытое поле» увеличивался у экспериментальных, но снижался у контрольных животных. В указанный период число пересеченных периферических секторов установки у крыс с индуцированным болевым синдромом было меньше контрольных значений. Через 2 недели после введения моноиодацетата натрия в височно-нижнечелюстной сустав число исследованных объектов в группе с остеоартритом было больше по сравнению с интактными особями. Заключение. Экспериментальный остеоартрит височно-нижнечелюстного сустава у самок крыс приводит к выраженному угнетению ориентировочно-исследовательского поведения при тестировании в открытом поле.
The aim: to investigate the orientation-research behaviour of female rats in the dynamics of observations in the “open field” test on the model of pain in the maxillofacial region. Material and methods. The study was conducted on 18 female Wistar rats. Osteoarthritis of the temporomandibular joint was induced by intra-articular injection of sodium monoiodoacetate. Behavioral performance was recorded in the open-field test. Measurements were taken at baseline and 14 days after reagent administration. Results. It was shown that female rats with pain syndrome were characterized by a decrease in the number of movements in peripheral sectors and an increase in grooming time. By the end of observations, the latent period of the first movement in the “open field” test increased in experimental animals, but decreased in control animals. During this period, the number of crossed peripheral sectors of the plant in rats with induced pain syndrome was lower than the control values. 2 weeks after the injection of sodium monoiodacetate into the temporomandibular joint, the number of examined objects in the group with osteoarthritis was greater compared to intact individuals. Conclusion. Experimental osteoarthritis of the temporomandibular joint in female rats leads to a pronounced inhibition of orienteering and exploratory behavior during open-field testing.
Значимость группы генов длинных некодирующих РНК в прогрессии рака яичников
Authors: С.С. Лукина , А.М. Бурдённый , И.В. Пронина , В.И. Логинов , Э.А. Брага 
Published: October 2024

Рак яичников относится к наиболее агрессивным и неблагоприятным формам рака у женщин с быстрым прогрессированием и высоким метастатическим потенциалом. Ключевую роль в развитии этого заболевания может играть нарушение эпигенетической регуляции экспрессии длинных некодирующих РНК (днРНК) вследствие аберрантного метилирования их генов. Цель: изучить характер метилирования и экспрессии генов днРНК GAS5, HOTAIR и SNHG6 в опухолях больных раком яичников и оценить связь этих эпигенетических нарушений с прогрессией и метастазированием заболевания. Методы: Анализ уровней метилирования и экспрессии днРНК проводили методом ПЦР в реальном времени на выборке парных (опухоль/норма) образцов, полученных от пациенток с раком яичников. Статистический и корреляционный анализ выполняли в программной среде R. Результаты: Выявлено значимое повышение уровня метилирования генов GAS5, HOTAIR и SNHG6 в опухолевой ткани по сравнению с нормой. Тот же результат показан для генов GAS5 и SNHG6 при прогрессии опухоли, включая метастазирование. Уровень экспрессии при этом для HOTAIR и SNHG6 значимо снижался в опухоли. Выявлена отрицательная корреляция между уровнем метилированием гена SNHG6 и уровнем его экспрессии. Заключение: Полученные данные указывают на важную роль эпигенетической дерегуляции днРНК в патогенезе рака яичников и могут найти применение в прогнозировании и разработке персонализированных подходов к терапии.
Ovarian cancer is one of the most aggressive and unfavorable forms of cancer in women with rapid progression and high metastatic potential. A key role in the development of this disease may be played by a disruption in the epigenetic regulation of the expression of long non-coding RNAs (lncRNAs) due to aberrant methylation of their genes. Objective: To study the methylation and expression patterns of the lncRNA genes GAS5, HOTAIR, and SNHG6 in ovarian cancer tumors and evaluate the association of these epigenetic abnormalities with disease progression and metastasis. Methods: Analysis of lncRNA methylation and expression levels was performed by RT-PCR on paired (tumor/normal) samples obtained from ovarian cancer patients. Statistical and correlation analysis was performed in the R software environment. Results: A significant increase in the methylation level of the GAS5, HOTAIR, and SNHG6 genes was observed in tumor tissue compared to normal tissue. The same result was shown for the GAS5 and SNHG6 genes during tumor progression, including metastasis. The expression level for HOTAIR and SNHG6 was significantly decreased in the tumor. A negative correlation was found between the methylation level of the SNHG6 gene and its expression level. Conclusion: The obtained data indicate an important role of epigenetic deregulation of lncRNAs in the pathogenesis of ovarian cancer and may find application in predicting and developing personalized approaches to therapy.
Биоинформатический анализ генов и полиморфизмов, вовлеченных в старение и развитие заболеваний, ассоциированных с возрастом
Authors: А.А. Пахомов , Н.С. Карпова , О.П. Дмитренко 
Published: October 2024

Целью работы было проведение биоинформатического анализа полиморфизмов генов, которые ассоциированы со старением и возраст-ассоциированными заболеваниями. Материалы и методы. Анализ генов проводился с использованием информации, полученной из базы данных полногеномных ассоциативных исследований GWAS Catalog. Для анализа белок-белковых взаимодействий (protein-protein interactions, PPI) использовалась база данных String-DB (версия 12.0). Результаты. Выявлено 7676 уникальных генов, полиморфизмы которых связаны с развитием возраст-ассоциированных заболеваний. Выявлена ассоциация молекулярных функций ряда генов (HLA-DQB1, HLA-DQA1, HLA-DRB1, FTO, APOE, APOC1 и MAPT) и их белковых продуктов со старением и возраст-ассоциированными заболеваниями.
The aim of the study was to perform a bioinformatic analysis of gene’s polymorphisms, associated with ageing and ageassociated diseases. Materials and methods. Analysis of genes was performed with the use of information, obtained from the database of genomewide association studies GWAS Catalog. String-DB database (v. 12.0) was used for analysis of protein-protein interactions (PPI). Results. 7676 unique genes have been identified, the polymorphisms of which are associated with the development of ageassociated diseases. The association of molecular functions of a number of genes (HLA-DQB1, HLA-DQA1, HLA-DRB1, FTO, APOE, APOC1 and MAPT) and their protein products with aging and age-associated diseases has been revealed.
Федеральный исследовательский центр оригинальных и перспективных биомедицинских и фармацевтических технологий
Authors: О.С. Романенко , Д.А. Черемисова , А.В. Клименко , А.Ю. Любимова , С.С. Перцов 
Published: October 2024

Цель исследования: изучение изменений локомоторной активности, а также пищевого и питьевого поведения самок крыс на модели боли при остеоартрите височно-нижнечелюстного сустава. Материалы и методы. Исследования выполнены на 18 самках крыс Wistar. Животным вводили моноиодацетат натрия в височно-нижнечелюстной сустав. Для оценки суточной показателей двигательной активности крыс, объема потребляемой воды и пищи использовали автоматизированную установку Phenomaster (TSE Systems GmbH, Германия). Результаты. В динамике наблюдений установлено, что масса тела уменьшается у крыс с болевым синдромом, но увеличивается у контрольных животных. К окончанию опыта особи с индуцированной болью характеризовались снижением потребления корма и воды, а также уменьшением суточной двигательной активности. Заключение. Развитие болевого синдрома в челюстно-лицевой области приводит к подавлению локомоторной активности, угнетению пищевого и питьевого поведения.
The aim: study of changes in locomotor activity, as well as eating and drinking behavior of female rats on a model of pain in osteoarthritis of the temporomandibular joint. Material and methods. The studies were performed on 18 female Wistar rats. The animals were injected with sodium monoiodacetate in the temporomandibular joint. An automated Phenomaster unit (TSE Systems GmbH, Germany) was used to assess daily indices of the rats’ motor activity, water and food intake. Results. In the dynamics of observation it was found that body weight decreased in rats with pain syndrome, but increased in control animals. By the end of the experiment, individuals with induced pain were characterized by a decrease in feed and water consumption, as well as a decrease in daily motor activity. Conclusion. The development of pain syndrome in the maxillofacial region leads to suppression of locomotor activity, suppression of eating and drinking behavior.
Respiratory disease detection in lung auscultation with convolutional neural networks and CVAE augmentation
Authors: Panaskin D.V. , Stirenko S.H. , Babko D.S. 
Published: October 2024

The main purpose of this work was to investigate the possibility of detecting respiratory diseases in audio recordings of lung auscultation using modern deep learning tools, as well as to explore the possibility of using data augmentation by generating synthetic spectral representations of audio samples. The ICBHI (International Conference on Biomedical and Health Informatics) dataset was used for training, validation and augmentation. The dataset includes lung auscultations of 126 different subjects, there are a total of 920 sounds, of which 810 have signs of chronic diseases, 75 of non-chronic diseases and 35 with no pathology. The stage of data preprocessing includes discretization to 4kHz frequency, as well as filtering of frequency bands that do not carry information value for the task. In the next step, each sample was transformed into a frequency spectrum and Melspectrograms were generated. To solve the problem of class imbalance, the required number of synthetic spectrograms generated by convolutional variation autoencoders was added. At the stage of building the model, the methods of classical convolutional neural networks were used. The quality of the obtained algorithm was evaluated using a 10-fold cross-validation. Also, to assess the generalization of the proposed method, experiments were performed with the split of audio recordings into training and test sets using patient grouping. Qualitative evaluation of the model was performed using sensitivity, specificity, F1-score and Cohen’s kappa. A score of 98.45% F1-score was achieved for the 5-class classification problem which can contribute to the development of ways to synthesize and augment sensitive medical data. In addition, a cons of existing methods in the generalization of the obtained predictions were revealed, which opens the way for further research in the direction of clinical respiratory diseases detection.
Orthogonal Decompositions of Regular Graphs and Designing Tree-Hamming Codes
Authors: Shabana Hanan , El-Shanawany Ramadan , Halawa Sahar 
Published: October 2024

The paper introduces a concept of graph decomposition. That is orthogonal decompositions. Orthogonal decompositions of a graph H is a partitioning H into subgraphs of H such that any two subgraphs intersect in at most one edge. This decompositions are called G-orthogonal decompositions of H if and only if every subgraph in such decompositions is isomorphic to the graph G. Such decomposition appear in a lot of applications; statistics, information theory, in the theory of experimental design and many others. An approach of constructing orthogonal decompositions of regular graph is introduced here. Application of this approach for constructing tree -- orthogonal decompositions of complete bipartite graph is considered. Further, the use of orthogonal decompositions for designing hamming tree-codes is also discussed along with examples. The study shows that such codes have an efficient properties when are used to detect and correct the errors that may occur during a transmission of data through a network. Furthermore, we present a method for the recursive construction of orthogonal decompositions.
Common Fixed Point of Generalized Berinde Type Contraction and an Application
Authors: Alsamir Habes , Qawaqneh Haitham Ali , Al-Musannef Gawhara , Khalil Roshdi 
Published: October 2024

In this paper, we introduce $\lambda_{(s,\varphi,\psi,L)}$-generalized Berinde type contraction and obtain some common fixed point results for such class of contractions the setting of triangular $\alpha$-admissible mappings with respect to $\eta$ in the framework of $b$-metric spaces. Our results generalize and extend some theorems in the literature. An example is given to support our result.
On b-Coloring Analysis of Graphs: An Application to Spatial-Temporal Graph Neural Networks for Multi-Step Time Series Forecasting of Soil Moisture and pH in Companion Farming
Authors: Kristiana Arika Indah , Rachmasari Elisa , . Dafik , Agustin Ika Hesti , Mursyidah Indah Lutfiyatul , Alfarisi Ridho 
Published: October 2024

Let $G$ be a pair of two sets $(V,E)$ with vertex set $V$ and edge set $E$. A proper coloring of a graph $G$ is a vertex coloring of it such that no two adjacent vertices in $G$ have the same color. By $b-$Coloring, we define a coloring of the vertex of $G$ such that each color class has at least one vertex that adjacent with all other color classes. The $b-chromatic$ number of graph $G$, denoted by $\varphi(G),$ is the largest integer $k$ such that graph $G$ has $b-$Coloring with $k$ colors. In this paper, we will explore some new lemmas or theorems regarding to $\varphi(G)$. Furthermore, to see the robust application of $b-$Coloring of graph, at the end of this paper we will illustrate the implementation of $b-$Coloring on spatial temporal graph neural networks (STGNN) multi-step time series forecasting on soil moisture and $pH$ of companion farming.
On a Hybrid Class of $p$-Laplacian Initial Value Problems with Modified Mittag-Leffler Kernel
Authors: Sowmiya Ramasamy  , Kavitha Velusamy  , Dumitru Baleanu  , Mani Mallika Arjunan 
Published: October 2024

In this work, we establish key results on the existence theory for a category of initial value problems (IVPs) involving hybrid fractional integro-differential equations (HFIDEs) with a $p$-Laplacian operator, utilizing the modified Mittag-Leffler kernel. By employing Krasnoselskii and Banach fixed point theorems (FPTs), we determine the conditions required for the existence of solutions. Additionally, we examine the Hyers-Ulam (H-U) stability of the problem. Lastly, we present an example to confirm our theoretical results.