bluuebunny/crossref_metadata_2025_split huggingface dataset:
Políticas públicas e as lutas por memória e justiça: contradições e limites
Authors: Campos Lucas Pacheco 
Published: April 2018

Este artigo reflete sobre a trajetória de lutas empreendidas pelo Grupo Tortura Nunca Mais do Rio de Janeiro (GTNM-RJ) e sobre a absorção das pautas por memória e justiça pelo Estado. Busca-se pensar os impactos concretos que a implementação de políticas públicas de memória tem gerado para superar as páginas de tortura da história nacional. Para tanto, apresentam-se exemplos de ações desenvolvidas pelo GTNM-RJ em seus mais de 33 anos de existência e o diálogo das mesmas com governos e aparelhos estatais. Em especial, analisam-se os resultados produzidos por uma política pública de memória específica: a Comissão Nacional da Verdade (CNV), que se configura como resposta a demandas históricas por verdade, memória e justiça. Observam-se, por fim, as contradições e os limites intrínsecos à crença de que tais reivindicações históricas poderão ser finalmente atendidas pelo Estado, por meio da concepção e aplicação de políticas públicas de memória. Aponta-se para a necessidade imperiosa de se refletir sobre as estratégias das lutas por memória e justiça. Palavras-chave: Grupo Tortura Nunca Mais-RJ (GTNM-RJ); lutas por memória e justiça; políticas públicas; Comissão Nacional da Verdade (CNV).
Mid-term results of anatomical total shoulder arthroplasty for primary osteoarthritis using a short-stemmed cementless humeral component
Authors: Schnetzke M. , Rick S. , Raiss P. , Walch G. , Loew M. 
Published: April 2018

Aims The aim of this study was to evaluate the clinical and radiological outcome of using an anatomical short-stem shoulder prosthesis to treat primary osteoarthritis of the glenohumeral joint. Patients and Methods A total of 66 patients (67 shoulders) with a mean age of 76 years (63 to 92) were available for clinical and radiological follow-up at two different timepoints (T1, mean 2.6 years, sd 0.5; T2, mean 5.3 years, sd 0.7). Postoperative radiographs were analyzed for stem angle, cortical contact, and filling ratio of the stem. Follow-up radiographs were analyzed for timing and location of bone adaptation (cortical bone narrowing, osteopenia, spot welds, and condensation lines). The bone adaptation was classified as low (between zero and three features of bone remodelling around the humeral stem) or high (four or more features). Results The mean Constant score improved significantly from 28.5 (sd 11.6) preoperatively to 75.5 (sd 8.5) at T1 (p < 0.001) and remained stable over time (T2: 76.6, sd 10.2). No stem loosening was seen. High bone adaptation was present in 42% of shoulders at T1, with a slight decrease to 37% at T2. Cortical bone narrowing and osteopenia in the region of the calcar decreased from 76% to 66% between T1 and T2. Patients with high bone adaptation had a significantly higher mean filling ratio of the stem at the metaphysis (0.60, sd 0.05 vs 0.55, sd 0.06; p = 0.003) and at the diaphysis (0.65 sd 0.05 vs 0.60 sd 0.05; p = 0.007). Cortical contact of the stem was also associated with high bone adaptation (14/25 shoulders, p = 0.001). The clinical outcome was not influenced by the radiological changes. Conclusion Total shoulder arthroplasty using a short-stem humeral component resulted in good clinical outcomes with no evidence of loosening. However, approximately 40% of the shoulders developed substantial bone loss in the proximal humerus at between four and seven years of follow-up. Cite this article: Bone Joint J 2018;100-B:603–9.
The influence of obesity on functional outcome and quality of life after total knee arthroplasty
Authors: Xu S. , Chen J. Y. , Lo N. N. , Chia S. L. , Tay D. K. J. ,  Pang H. N. , Hao Y. , Yeo S. J. 
Published: April 2018

AimsThis study investigated the influence of body mass index (BMI) on patients’ function and quality of life ten years after total knee arthroplasty (TKA).Patients and MethodsA total of 126 patients who underwent unilateral TKA in 2006 were prospectively included in this retrospective study. They were categorized into two groups based on BMI: < 30 kg/m2(control) and ≥ 30 kg/m2(obese). Functional outcome was assessed using the Knee Society Function Score (KSFS), Knee Society Knee Score (KSKS), and Oxford Knee Score (OKS). Quality of life was assessed using the Physical (PCS) and Mental Component Scores (MCS) of the 36-Item Short-Form Health Survey.ResultsPatients in the obese group underwent TKA at a younger age (mean, 63.0 years, sd 8.0) compared with the control group (mean, 65.6 years, sd 7.6; p = 0.03). Preoperatively, both groups had comparable functional and quality-of-life scores. Ten years postoperatively, the control group had significantly higher OKS and MCS compared with the obese group (OKS, mean 18 (sd 5) vs mean 22 (sd 10), p = 0.03; MCS, mean 56 (sd 10) vs mean 50 (sd 11), p = 0.01). After applying multiple linear regression with the various outcomes scores as dependent variables and age, gender, and Charlson Comorbidity Index as independent variables, there was a clear association between obesity and poorer outcome in KSFS, OKS, and MCS at ten years postoperatively (p < 0.01 in both KSFS and OKS, and p = 0.03 in MCS). Both groups had a high satisfaction rate (97.8% in the control group vs 87.9% in the obese group, p = 0.11) and fulfillment of expectations at ten years (98.9% in the control group vs 100% in the obese group, p = 0.32).ConclusionAlthough both obese and non-obese patients have significant improvements in function and quality of life postoperatively, obese patients tend to have smaller improvements in the OKS and MCS ten years postoperatively. It is important to counsel patients on the importance of weight management to achieve a more sustained outcome after TKA. Cite this article: Bone Joint J 2018;100-B:579–83.
The inter- and intraobserver reliability for the radiological parameters of flatfoot, before and after surgery
Authors: Bock P. , Pittermann M. , Chraim M. , Rois S. 
Published: April 2018

AimsVarious radiological parameters are used to evaluate a flatfoot deformity and their measurements may differ. The aims of this study were to answer the following questions: 1) Which of the 11 parameters have the best inter- and intraobserver reliability in a standardized radiological setting? 2) Are pre- and postoperative assessments equally reliable? 3) What are the identifiable sources of variation?Patients and MethodsMeasurements of the 11 parameters were recorded on anteroposterior and lateral weight-bearing radiographs of 38 feet before and after surgery for flatfoot, by three observers with different experience in foot surgery (A, ten years; B, three years; C, third-year orthopaedic resident). The inter- and intraobserver reliability was calculated.ResultsPreoperative interobserver reliability was high for four, moderate for five, and low for two parameters. Postoperative interobserver reliability was high for four, moderate for five, and low for two parameters. Intraobserver reliability was excellent for all parameters preoperatively as recorded by observer A (PB) and B (MP), and for eight parameters as recorded by observer C (SR). Intraobserver reliability was excellent for ten parameters postoperatively as recorded by observer A and B, and for eight parameters as recorded by observer C.ConclusionThe following parameters can be recommended. For preoperative and postoperative evaluation of flatfoot: anteroposterior, talonavicular coverage angle; lateral, talometatarsal I angle, calcaneal pitch angle, and cuneiform-medial height (high interobserver reliability); and anteroposterior, talometatarsal II angle; lateral, talocalcaneal angle,tibiocalcaneal angle (moderate interobserver reliability). For more experienced observers, we also recommend the anteroposterior talometatarsal I angle (moderate reliability). The inter- and intraobserver reliability for most parameters were similar pre- and postoperatively. The experience of the observer and the definition and ability to measure the parameters themselves were sources of variation. Cite this article: Bone Joint J 2018;100-B:596–602.
Day-case surgery for total hip and knee replacement
Authors: Lazic Stefan , Boughton Oliver , Kellett Catherine F. , Kader Deiary F. , Villet Loïc , Rivière Charles 
Published: April 2018

Multimodal protocols for pain control, blood loss management and thromboprophylaxis have been shown to benefit patients by being more effective and as safe (fewer iatrogenic complications) as conventional protocols. Proper patient selection and education, multimodal protocols and a well-defined clinical pathway are all key for successful day-case arthroplasty. By potentially being more effective, cheaper than and as safe as inpatient arthroplasty, day-case arthroplasty might be beneficial for patients and healthcare systems. Cite this article: EFORT Open Rev 2018;3:130-135. DOI: 10.1302/2058-5241.3.170031
Patellar tracking in primary total knee arthroplasty
Authors: Donell Simon 
Published: April 2018

This is a review of the recent literature of the various factors that affect patellar tracking following total knee arthroplasty (TKA). Patellar tracking principally depends on the pre-existing patellar tracking and the rotational alignment of the femoral and tibial implants, but the detailed movements depend on the patellar shape. The latter means that the patellar kinematics of any implanted TKA does not return to normal. Laboratory cadaveric studies use normal knees and non-activity-based testing conditions and so may not translate into clinical findings. The recent literature has not added anything significant to change established clinical practice in achieving satisfactory patellar tracking following TKA.Cite this article: EFORT Open Rev 2018;3:106-113. DOI: 10.1302/2058-5241.3.170036.
A Critique of the Concepts of “Youth” and “Generation” as Applied in Empirical Research in Contemporary Tunisia
Authors: Roellin Jonas 
Published: April 2018

Abstract
In this paper, I argue that both concepts of “youth” (arabic “šabāb”) and “generation” (arabic “ğīl”) are in different ways misleading and problematic when applied in empirical research on Tunisians of lower age. While they are not affirmatively used and partly even rejected by the latter, they also appear inadequate when employed as analytical categories. Instead, as I will suggest, (historical) “age cohort” is an adequate reference category that can be qualitatively described according to the shared perceptions and actions of its respective members. Thereby, the focus on self-concepts and self-narratives appears to be particularly helpful in understanding the contemporary condition of Tunisians of lower age and their social mobilization practices. It reveals, among other findings, that their movements are not primarily directed at political and social change, though conventionally assumed, but rather express a search for greater possibilities of mobility and autonomy beyond both state and societal boundaries.
Effects of Chemical Structure of Silicone Polyethers Used as Fabric Softener Additives on Selected Utility Properties of Cotton Fabric
Authors: Zięba Małgorzata , Małysa Anna , Wasilewski Tomasz , Ogorzałek Marta 
Published: April 2018

Abstract
The study addressed the effect of the structure of silicone polyethers on selected functional properties of cotton fabric rinsed in conditioners containing the additives under study. Fabric softener formulations containing two comb-structured compounds (PEG/PPG-14/0 Dimethicone and PEG/PPG-20/20 Dimethicone) and one block-structured compound (Bis-PEG/PPG-20/20 Dimethicone) were developed. Cotton fabric rinsed in conditioners containing silicone glycols was not found to be affected by yellowing. However, differences were noted in the softening ability and re-wettability of rinsed fabrics due to diverse structures of the additives used. The most desirable soft hand effect was observed after cotton rinsing in fabric softeners containing the block-structured compound Bis-PEG/PPG-20/20 Dimethicone. In contrast, the highest fabric re-wettability was shown for the conditioner enriched with a comb-structured compound (PEG/PPG-20/20 Dimethicone). The study results demonstrate that the prototypical fabric softeners containing silicone derivatives have a potential to provide quality characteristic required by consumers of this product group.
Agrofuels Controversy in the Midst of the International Crisis
Authors: Rodríguez Valle Liosdany , de Jesús Echerri Ferrandiz Fernando , Correa Álvarez Pascual Felipe , Sosa Valcarcel Aimiris 
Published: April 2018

Abstract
The current crisis in the supply of traditional energies, the rising trend of the price of fossil fuels, the degradation of the environment, the effects of climate change and the geopolitical reazons have set the promotion of alternative energies, among which agrofuels stand out, as a priority for international and national policies. They represent a potential source of energy, but it is necessary to debate and carefully evaluate the economic, environmental and social effects before undertaking large-scale programs. This article exposes the main edges of the political-economic, scientific-technological and ethical debate, arising from the global controversy generated by the boom in the production and use of agrofuels, which took place at the beginning of the world crisis that reached public repercussion from August 2007. Although the international debate had its apogee between 2007 and 2008, it is a controversy that has spread over time to the present, but with a lower profile.
Some remarks on spectra of nuclear operators
Authors: Reinov Oleg I. 
Published: April 2018

Abstract
We give criteria for the spectra of some nuclear operators in subspaces of quotients of Lp
-spaces to be central-symmetric, as well as for the spectra of linear operators in Banach spaces to be Zd
-symmetric in the sense of B. Mityagin. Also, we present a short proof of a corresponding Mityagin’s theorem.
Die Causa Lutheri in der Pönitentiarie
Authors: Schmugge Ludwig 
Published: April 2018

Riassunto
Nei registri della Penitenzieria apostolica, l’organo pontificio in materia di penitenza, confessione e grazia, il nome di „Lutero“ appare in numerose suppliche provenienti dai territori tedeschi. I testi non risalgono al riformatore, ma furono prodotti da contemporanei coinvolti, in un modo o l’altro, in eventi che vengono messi in relazione con la presenza di Lutero nell’Impero germanico. Si tratta in massima parte di „squarci su vite modeste“ (Arnold Esch). Tuttavia, vi hanno lasciato traccia anche alcuni tra i piu importanti avversari del monaco di Wittenberg (Johannes Fabri, Konrad Kling e Johannes Debneck, detto Cochleus).
Invariants of the Axisymmetric Plasma Flows
Authors: Bogoyavlenskij Oleg 
Published: April 2018

Abstract
Infinite families of new functionally independent invariants are derived for the axisymmetric dynamics of viscous plasmas with zero electrical resistance. As a consequence, we find that, if two axisymmetric plasma states are dynamically connected, then their total number of magnetic rings must be equal (the same as for the total numbers of magnetic blobs) and the corresponding infinitely many new invariants must coincide.
Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer’s Disease
Authors: Brown Rosalind , Lam Alice D. , Gonzalez-Sulser Alfredo , Ying Andrew , Jones Mary , Chou Robert Chang-Chih , Tzioras Makis , Jordan Crispin Y. , Jedrasiak-Cape Izabela , Hemonnot Anne-Laure , Abou Jaoude Maurice , Cole Andrew J. , Cash Sydney S. , Saito Takashi , Saido Takaomi , Ribchester Richard R. , Hashemi Kevan , Oren Iris 
Published: April 2018

AbstractNetwork hyperexcitability is a feature of Alzheimer’ disease (AD) as well as numerous transgenic mouse models of AD. While hyperexcitability in AD patients and AD animal models share certain features, the mechanistic overlap remains to be established. We aimed to identify features of network hyperexcitability in AD models that can be related to epileptiform activity signatures in AD patients. We studied network hyperexcitability in mice expressing amyloid precursor protein (APP) with mutations that cause familial AD, and compared a transgenic model that overexpresses human APP (hAPP) (J20), to a knock-in model expressing APP at physiological levels (APPNL/F). We recorded continuous long-term electrocorticogram (ECoG) activity from mice, and studied modulation by circadian cycle, behavioral, and brain state. We report that while J20s exhibit frequent interictal spikes (IISs), APPNL/Fmice do not. In J20 mice, IISs were most prevalent during daylight hours and the circadian modulation was associated with sleep. Further analysis of brain state revealed that IIS in J20s are associated with features of rapid eye movement (REM) sleep. We found no evidence of cholinergic changes that may contribute to IIS-circadian coupling in J20s. In contrast to J20s, intracranial recordings capturing IIS in AD patients demonstrated frequent IIS in non-REM (NREM) sleep. The salient differences in sleep-stage coupling of IIS in APP overexpressing mice and AD patients suggests that different mechanisms may underlie network hyperexcitability in mice and humans. We posit that sleep-stage coupling of IIS should be an important consideration in identifying mouse AD models that most closely recapitulate network hyperexcitability in human AD.
Dissociation between CSD-Evoked Metabolic Perturbations and Meningeal Afferent Activation and Sensitization: Implications for Mechanisms of Migraine Headache Onset
Authors: Zhao Jun , Levy Dan 
Published: April 2018

The onset of the headache phase during attacks of migraine with aura, which occur in ∼30% of migraineurs, is believed to involve cortical spreading depression (CSD) and the ensuing activation and sensitization of primary afferent neurons that innervate the intracranial meninges, and their related large vessels. The mechanism by which CSD enhances the activity and mechanosensitivity of meningeal afferents remains poorly understood, but may involve cortical metabolic perturbations. We used extracellular single-unit recording of meningeal afferent activity and monitored changes in cortical blood flow and tissue partial pressure of oxygen (tpO2) in anesthetized male rats to test whether the prolonged cortical hypoperfusion and reduction in tissue oxygenation that occur in the wake of CSD contribute to meningeal nociception. Suppression of CSD-evoked cortical hypoperfusion with the cyclooxygenase inhibitor naproxen blocked the reduction in cortical tpO2, but had no effect on the activation of meningeal afferents. Naproxen, however, distinctly prevented CSD-induced afferent mechanical sensitization. Counteracting the CSD-evoked persistent hypoperfusion and reduced tpO2by preemptively increasing cortical blood flow using the ATP-sensitive potassium [K(ATP)] channel opener levcromakalim did not inhibit the sensitization of meningeal afferents, but prevented their activation. Our data show that the cortical hypoperfusion and reduction in tpO2that occur in the wake of CSD can be dissociated from the activation and mechanical sensitization of meningeal afferent responses, suggesting that the metabolic changes do not contribute directly to these neuronal nociceptive responses.SIGNIFICANCE STATEMENTCortical spreading depression (CSD)-evoked activation and mechanical sensitization of meningeal afferents is thought to mediate the headache phase in migraine with aura. We report that blocking the CSD-evoked cortical hypoperfusion and reduced tissue partial pressure of oxygen by cyclooxygenase inhibition is associated with the inhibition of the afferent sensitization, but not their activation. Normalization of these CSD-evoked metabolic perturbations by activating K(ATP) channels is, however, associated with the inhibition of afferent activation but not sensitization. These results question the contribution of cortical metabolic perturbations to the triggering mechanism underlying meningeal nociception and the ensuing headache in migraine with aura, further point to distinct mechanisms underlying the activation and sensitization of meningeal afferents in migraine, and highlight the need to target both processes for an effective migraine therapy.
Screening for germline KCNQ1 and KCNE2 mutations in a set of somatotropinoma patients
Authors: Iivonen Anna-Pauliina , Känsäkoski Johanna , Karppinen Atte , Kivipelto Leena , Schalin-Jäntti Camilla , Karhu Auli , Raivio Taneli 
Published: April 2018

Objective
Recently, mutations in KCNQ1, a potassium channel gene usually linked to long QT syndrome, were reported to cause maternally inherited gingival fibromatosis and growth hormone deficiency (GHD). Expression of the mutated KCNQ1 with the auxiliary potassium channel subunit KCNE2 was shown to reduce pituitary hormone secretion in functional experiments. Here, we investigated if germline mutations in KCNQ1 and KCNE2 were present in patients with somatotropinomas, which represent a model of growth hormone excess.

Design and methods
KCNQ1 and KCNE2 were screened for germline mutations in 53 patients with acromegaly by Sanger sequencing. Effects of the variants were predicted by in silico tools.

Results
Only deep intronic and synonymous polymorphisms were detected in KCNQ1. These findings were likely insignificant based on in silico predictions and the variants’ frequencies in the general population. In KCNE2, a heterozygous c.22A>G, p.(Thr8Ala) mutation with unknown significance was found in three patients. It was present in the database controls with a frequency of 0.0038.

Conclusions
KCNQ1 or KCNE2 mutations do not appear to account for somatotropinoma formation, although larger patient series are needed to validate the findings.
Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study
Authors: Salamun Vesna , Jensterle Mojca , Janez Andrej , Vrtacnik Bokal Eda 
Published: April 2018

ObjectiveGlucagon-like peptide-1 (GLP-1) has been investigated in regulation of reproductive system in animal models. The potential impact of short-term preconception intervention with liraglutide on fertility potential in polycystic ovary syndrome (PCOS) has not been evaluated yet.DesignA prospective randomized open-label study was conducted in 28 infertile obese PCOS patients (age: 31.07 ± 4.75, BMI: 36.7 ± 3.5 kg/m2, mean ± s.d.). They were assigned to metformin (MET) 1000 mg BID or to MET 1000 mg BID combined with low-dose liraglutide 1.2 mg QD s.c. (COMBI) for 12 weeks. Ovarian stimulation protocol was started after a 4-week medication-free period.MethodsThein vitrofertilization pregnancy rate (PR) was defined as the number of clinical pregnancies confirmed by ultrasound visualization of the fetal cardiac activity, divided by the total number of cycles performed or embryo transfers (ET). The spontaneous PR was followed for 12 months.ResultsPatients in the MET group on average lost 7.0 ± 6.0 kg (P = 0.001) compared with 7.5 ± 3.9 kg in the COMBI group (P < 0.001) with no significant between-treatment difference (P = 0.246). The PR per ET was significantly higher in the COMBI (85.7%) compared with the MET (28.6%) group (P = 0.03). The cumulative PR in the time frame of 12 months was 69.2% in the COMBI group compared to 35.7% in the MET group.ConclusionsPreconception intervention with low-dose liraglutide added to metformin is superior to metformin alone in increasing PRs per ET and cumulative PRs in infertile obese women with PCOS, despite comparable weight reduction in both groups. A potential impact of liraglutide on the reproductive system needs further exploration, in particular the GLP-1 impact on endometrial quality and receptivity.