bluuebunny/crossref_metadata_2025_split huggingface dataset:
RP-HPLC Estimation of Flavonol Derivatives and Phenolic Acids in Capsicum annuum L. and their Correlation with In Vitro Anti-Inflammatory Activity
Authors: Iqbal Zahra , Ahmad Ausaf , Haque Ziyaul , Khan Mohammed S. , Khan Mohd S. , Iqbal Mohammed S. 
Published: September 2019

Background:Flavonol derivative and phenolic acids derived from the plants function as free radical scavengers, reducing agents, and quenchers for the formation of singlet oxygen. Flavonoids and phenolic constituents also play an important role in various human diseases and disorders primarily through modulation of inflammatory responses.Objective:To estimate the Flavonol Derivatives (FD) and phenolic acids (PA) in Capsicum annuum (CA) and other important phytochemicals having an anti-inflammatory effect.Method:In the present study, FD and PA were estimated in CA and in vitro anti-inflammatory activity (pilot study) was determined and correlation was established.Results:The results were found to be significant using RP-HPLC. FD and PA were found to be 0.0659±0.0058 and 0.0862±0.0.0134 mg/gram dry weight, respectively. For in vitro anti-inflammatory activity, the inhibition of albumin denaturation and antiproteinase activity was found to be maximum in Quercetin (QE) with 98.230±1.589% and 59.906±1.529%, respectively. Heat-induced hemolysis of erythrocytes was found to be maximum in salicylic acid (SA) (71.830±2.838%). Hypotonicity-induced hemolysis showed significant activity with QE (76.770±3.475%). Lipoxygenase and cyclooxygenase inhibition was found to be maximum in QE with 56.930±4.069% and 61.660±3.135%, respectively.Conclusion:A strong positive correlation of 0.9 was observed between the extract of CA and standard QE and SA against the anti-inflammatory activity. Therefore, the role of FD and PA has been postulated to be an active phytochemical of CA accountable for its anti-inflammatory activity. However further work is desirable to fully elucidate the phytochemicals responsible for their anti-inflammatory activity and to develop better herbal drug formulations.
Synthesis,In VitroEvaluation, Molecular Docking and DFT Studies of Some Phenyl Isothiocyanates as Anticancer Agents
Authors: Richa Kikoleho , Karmaker Rituparna , Longkumer Naruti , Das Vishal , Bhuyan Pulak J. , Pal Mintu , Sinha Upasana B. 
Published: September 2019

Background:Isothiocyanates (ITCs) are small molecules that are important in synthetic organic chemistry, but their actual importance lies in their potential as anti-carcinogens. Through this piece of work, an effort was made to assess the anti-cancer activity of some simple ITCs which can be synthesized through easy greener pathways.Methods:Cell proliferation assay was performed on ovarian cancer cells (PA-1) and non-tumorigenic ovarian epithelial cells (IOSE-364). Furthermore, qRT-PCR for transcript expression levels of Spindlin1 and caspases in ovarian cancer cells and cell cycle analysis was performed. In silico studies were incorporated to understand the mode of ligand-protein interaction, ADME/Toxicity and drug-likeliness parameters. Density functional theory studies have been also been employed on the ITCs to assess their efficiency in anticancer activity.Results:An inexpensive, environmentally benign pathway has been developed for synthesizing a series of ITCs. Among the synthesized ITCs, NC6 showed better cytotoxic effects as compared to its counterparts. Novel findings revealed that NC6 had 5-folds lower transcript expression levels of Spindlin1 and induced caspases 3 and 7 expressions assessed by qRT-PCR in ovarian cancer cells. Furthermore, flow cytometry assay showed the cell cycle arrest at G1/S phase of cell cycle. The molecular docking studies revealed favorable binding affinities and the physiochemical parameters were predicted to be compatible with drug-likeliness.Conclusion:The results demonstrated the possibility that small isothiocyanate molecules which can be synthesized by a simple green methodology, can pose as promising candidates for their application as anticancer agents.
Synergistic Effect of α-Solanine and Cisplatin Induces Apoptosis and Enhances Cell Cycle Arrest in Human Hepatocellular Carcinoma Cells
Authors: El-Daly Sherien M. , Gouhar Shaimaa A. , Gamal-Eldeen Amira M. , Abdel Hamid Fatma F. , Ashour Magdi N. , Hassan Nahla S. 
Published: September 2019

Aim:The clinical application of cisplatin is limited by severe side effects associated with high applied doses. The synergistic effect of a combination treatment of a low dose of cisplatin with the natural alkaloid α-solanine on human hepatocellular carcinoma cells was evaluated.Methods:HepG2 cells were exposed to low doses of α-solanine and cisplatin, either independently or in combination. The efficiency of this treatment modality was evaluated by investigating cell growth inhibition, cell cycle arrest, and apoptosis enhancement.Results:α-solanine synergistically potentiated the effect of cisplatin on cell growth inhibition and significantly induced apoptosis. This synergistic effect was mediated by inducing cell cycle arrest at the G2/M phase, enhancing DNA fragmentation and increasing apoptosis through the activation of caspase 3/7 and/or elevating the expression of the death receptors DR4 and DR5. The induced apoptosis from this combination treatment was also mediated by reducing the expression of the anti-apoptotic mediators Bcl-2 and survivin, as well as by modulating the miR-21 expression.Conclusion:Our study provides strong evidence that a combination treatment of low doses of α-solanine and cisplatin exerts a synergistic anticancer effect and provides an effective treatment strategy against hepatocellular carcinoma.
DARI DAMARWULAN KE JINGGOAN: DINAMIKA KESENIAN JANGER DI BANYUWANGI 1930’AN-1970
Authors: Nurullita Hervina - 
Published: September 2019

ABSTRAKPenelitian ini berangkat dari sebuah pertanyaan bagaimana sejarah kesenian Janger yang sangat populer di Banyuwangi berkembang dengan pesat dan masih menjadi minat masyarakat dari tahun 1930’an sampai sekarang. Janger yang merupakan akulturasi dari Jawa, Bali dan Banyuwangi terus dilestarikan oleh para seniman pendukungnya. Janger identik dengan lakon Damarwulan-Minakjinggo pun menjadi perdebatan antara sejarah dan fiksi. Penelitian ini menggunakan metode penelitian sejarah yang terdiri dari heuristik, kritik, interpretasi dan historiografi. Hasil penelitian menyebutkan bahwa akulturasi dari seni Janger inilah yang menyebabkan kelestarian Janger Banyuwangi. Selain itu banyak dari seniman Banyuwangi yang menggantungkan hidupnya dari kesenian ini. Kata Kunci: Janger, Banyuwangi, Damarwulan-Minakjinggo, Akulturasi. ABSTRACTThis research come from the question history of Janger which too popular in Banyuwangi and still exist since 1930st until now. Janger is tradisional drama which acculturation from Java, Bali and Bali. Janger identic with story about Damarwulan-Minakjinggo. This story stil argued fiction or non fiction. Thi research using historical method such as heuristic, critic, interpretation and historiography. Result from this research know that acculturation between Java, Bali and Banyuwangi which make them sustainable until now. And the other many artist depend on their life in this drama. Keywords: Janger, Banyuwangi, Damarwulan-Minakjinggo, Acculturation
Characteristics, Opportunities, and Challenges of Osteopathy (COCO) in the Perceptions of Osteopaths in Germany, Austria, and Switzerland: Protocol for a Comprehensive Mixed Methods Study
Authors: Porthun Jan , Manschel Jonas 
Published: September 2019

BackgroundCurrently, the importance of osteopathy within the health care system is controversial. The training structures and the acknowledgment of the occupational profile strongly differ in the German-speaking territory.ObjectiveThis study aims to examine the characteristics of the osteopathic profession as well as the possibilities and challenges for osteopaths in Germany, Austria, and Switzerland.MethodsThis study adopted a mixed methods design. The research topic will be examined based on qualitative and quantitative partial studies that will be conducted in parallel as well as sequentially. By applying different research methods and sample testing and by using standardized, validated measurement methods, we expect to be able to gain new insights into the work area of osteopathy.ResultsIn November 2018, we started the research and data collection. Currently, we are conducting the first two partial studies. The planned duration of each of the partial study is 6-9 months. The project is scheduled to be completed in 2021.ConclusionsThis study will examine how osteopaths define themselves in comparison with professionals from other occupational profiles and how they describe the characteristics of their work. The identification of central issues is expected to help clarify the issues and define the profession. As such, the results might contribute to the conservation and improvement of the quality of osteopathic treatment.International Registered Report Identifier (IRRID)PRR1-10.2196/15399
A Tecnologia: Algumas Reflexões Socioespaço-Temporais
Authors: Júnior Donarte Nunes dos Santos , Lahm Regis Alexandre 
Published: September 2019

O presente artigo propõe algumas reflexões sobre as sutis e específicas nuanças que se verificam na relação entre a tecnologia e as configurações socioespaciais. Tais aspectos se referem às alterações espaço-temporais ocasionadas pelos implementos tecnológicos, bem como, à forma como é estruturada e mantida a distribuição destes avanços. Para tanto, o texto (re)toma conceitos de raiz, apontando para algumas imprecisões quanto ao entendimento acerca das técnicas e das tecnologias, passando por questões midiáticas e epistemológicas.
O Discurso Da Sustentabilidade: Contradições E Intencionalidades
Authors: Giannella Letícia 
Published: September 2019

Os termos “sustentabilidade” e “desenvolvimento sustentável” têm tido, desde os anos 1970, destaque considerável nos círculos de discussão sobre o rumo das sociedades. A crise de um modelo capitalista neoliberal daria margens para novas formulações que serviriam como respostas aos problemas reais encontrados no mundo todo. Os termos têm encontrado lugar inclusive na escala cotidiana, estando presentes no senso comum de cada cidadão em cada parte do mundo globalizado. Todavia, o presente artigo procura demonstrar que os conceitos em questão da maneira que vêm sendo formulados e concebidos hegemonicamente acabam por servir apenas à perpetuação desse mesmo sistema capitalista que é aparentemente questionado. É preciso compreender que intencionalidade está presente nessas formulações e de que forma ela contribui para a manutenção do status quo. O trabalho consiste basicamente na compilação e organização das ideias de alguns autores que vêm se debruçando sobre o tema, a fim de organizá-las e costurá-las em uma linha argumentativa geral sobre as intencionalidades e contradições do discurso da sustentabilidade e desenvolvimento sustentável.
O Germe Da Mudança Ou A Possibilidade Latente De Resistência À Perversidade Da Globalização: Um Ensaio A Partir Das Músicas De Denúncia
Authors: Júnior Artur Monteiro Leitão , Soares Dayane Zandonadi , Filho Vitor Ribeiro 
Published: September 2019

A globalização constitui-se, fundamentalmente, em um processo multidimensional, afetando diretamente a organização econômica, as relações sociais, os padrões de vida e cultura, bem como gerando transformações do Estado e da política.Sob a perspectiva de avaliar os reflexos desse processo na esfera social, neste trabalho buscou-se focar o recorte que prima pela análise de músicas de diferentes estilos – rap, hip hop e reggae – sob o propósito de destacar certas formas de denúncia, mesmo que ínfimas em relevância à toda atuação massificadora e perpetuadora das condições precárias engendradas por este movimento financeiro-cultural. Essa denúncia evidencia-se enquanto uma forma de resistência cultural, própria da esfera local, abrindo novas possibilidades para a construção de um novo modelo de mundo.
A Produção E O Consumo Do Espaço Na Atual “Sociedade Do Consumo”
Authors: Junior Atilio Marchesini 
Published: September 2019

No presente artigo, pretendemos analisar parcialmente a produção do espaço e a sociedade atual do ponto de vista do consumo, a partir da influência da publicidade e do marketing em tal processo, juntamente com a relação do consumismo com as alterações ao meio ambiente e degradação dos recursos naturais, que provocam cada vez mais discussões no cenário científico, político e social mundial.
A LUTA PELO DIREITO À CIDADE POR MEIO DA STREET ART EM CURITIBA, PR
Authors: Oliveira Luiz Henrique 
Published: September 2019

A street art contemporânea tem sua origem na década de 1970, em Nova Iorque, intrinsecamente ligada à cultura hip hop, responsável pelo surgimento de tais expressões artísticas no Brasil. Com suas particularidades locais, atualmente ela pode ser entendida como um gênero artístico híbrido, destacando-se duas contradições inerentes a ela: a dualidade entre a pichação e o graffiti e o seu caráter político e territorial. Resultado da pesquisa de mestrado concluída em 2016, o trabalho se baseou nos seguintes procedimentos metodológicos: revisão bibliográfica, trabalhos de campo, registros fotográficos, análise de documentários e entrevistas. Por meio de uma análise crítica foram identificadas características que explicitam, em maior ou menor grau, a luta pelo direito à cidade. Compreende-se, então, que de forma dialética a street art pode se caracterizar como uma prática transformadora em direção à uma sociedade radicalmente diferente.
DE SÃO PAULO À PORTO ALEGRE: REFLEXIVIVENCIANDO A TROCA DE EXPERIÊNCIAS ENTRE PIBID E ESTÁGIOS DE LICENCIATURA NA BUSCA DA FORMAÇÃO DE BONS PROFESSORES
Authors: Kaercher Nestor André , Silva Jorge Luiz Barcellos da 
Published: September 2019

Qual o sentido de formar professores para a Educação Básica? Qual o sentido de ser professor na Educação Básica? Como pensar a construção da identidade do professor? São algumas questões que os autores - um em Guarulhos, SP (UNIFESP) formando pedagogas e o outro envolvido com a Licenciatura Noturna de Geografia, em Porto Alegre, RS (UFRGS) - pretendem reflexionar. Sem a pretensão de propor respostas ‘essencialistas’. A partir da experiência com o PIBID na UNIFESP e com os estágios finais de licenciatura na UFRGS, apontamos um pouco da trajetória dos alunos, no processo de sua formação. A busca de positividades e de fraquezas em ambas as experiências aponta-nos para a busca do professor reflexivo, aquele cuja ação evita ser repetitiva e acomodada.
O resgate da investigação ontológica na geografia através da fenomenologia-hermenêutica de Martin Heidegger
Authors: Reis Luis Carlos , Santos Josimar Monteiro 
Published: September 2019

O trabalho aborda a reflexão ontológica na Geografia a partir do pensamento de Heidegger. O objetivo é demonstrar que o modo com o qual se deu tanto a influência do pensamento de Heidegger no Geografia humanista; quanto, a reflexão sobre a ontologia na Geografia crítica-radical, obstruíram o alcance que o seu pensamento poderia assumir para tratar a fundamentação ontológica na disciplina.
Online Availability and Accessibility of Local Government Financial Statements: Is the Public Interest Being Served?
Authors: Vermeer Beth Y. , Styles Alan K. 
Published: September 2019

ABSTRACT
The purpose of this study is to examine the determinants of online availability and the ease of accessibility of U.S. municipality, county, school district, and special district audited financial statements. Using a sample of local governments that prepared 2017 audited financial statements, we find that certain forms of oversight by voters, auditors, and states are positively associated with the availability of audited financial statements. Our descriptive analysis also suggests that smaller governments, special districts, and school districts, many of which cover vast constituency populations, are lagging behind their municipality and county counterparts in online financial reporting. Our multivariate results suggest that as legislative/oversight bodies and citizens consider the potential benefits of additional forms of local government oversight, they should consider our findings that greater oversight is positively associated with the availability of local government audited financial statements.
Influence of Application Time on Dentin Bond Performance in Different Etching Modes of Universal Adhesives
Authors: Saito T , Takamizawa T , Ishii R , Tsujimoto A , Hirokane E , Barkmeier WW , Latta MA , Miyazaki M 
Published: September 2019

SUMMARY
We attempted to determine the effect of universal adhesive application time on dentin bond performance in different etching modes based on shear bond strength (SBS) tests and surface free energy (SFE) measurements. The five universal adhesives used were Adhese Universal (AU), Clearfil Universal Bond Quick (CQ), G-Premio Bond (GP), Scotchbond Universal (SU), and Tokuyama Universal Bond (TU). Bovine dentin specimens were divided into four groups of 10 for each adhesive. SBS and SFE were determined after applying the following surface treatments: 1) self-etch (SE) mode with immediate air blowing after adhesive application (IA treatment), 2) SE mode with prolonged application time (PA treatment), 3) etch-and-rinse (ER) mode with IA treatment, and 4) ER mode with PA treatment. Bonded specimens were subjected to SBS testing. The SFE of adhesive-treated dentin surfaces was measured after rinsing with acetone and water. Three-way analysis of variance revealed that dentin SBS values (p&lt;0.001) were significantly influenced by the factors of adhesive type and application duration, but the factor of pre-etching was not significant (p=0.985). The manufacturer's instructions require longer application times for AU and SU, which showed significantly lower SBS values in IA than in PA treatment in both etching modes. However, the difference in the other adhesives was not significant between the IA and PA treatments in either etching mode. The total SFE (γS) was dependent on the adhesive and etching mode. The γS value of the initial group (SiC paper ground group) at baseline was 69.5 (mN·m−1) and that of the pre-etching group at baseline was 30.6 (mN·m−1). For all the adhesives, γS in SE mode showed significantly higher values than in ER mode, regardless of the application time. In SE mode, almost all universal adhesives tested showed lower γS values in PA treatment than in IA treatment. For ER mode, all the adhesives showed significantly higher γS values than those of the pre-etching baseline, regardless of the application time. Most adhesives did not show any significant differences in γS values between IA and PA treatments, regardless of etching mode.
Experiencias juveniles en escenarios de inclusión digital
Authors: Fernández Massara Belén 
Published: September 2019

En este trabajo, la autora analiza las transiciones que emprenden los sujetos juveniles hacia experiencias sostenidas de apropiación de las tecnologías interactivas,encuadradas en el Programa Conectar Igualdad en dos etapas (2011 a 2013 y 2014-2015). La propuesta metodológica recupera las mediaciones tecnológicas en sus diversasdimensiones. Se aborda un caso considerado emblemático, la educación secundaria técnica en Olavarría (Buenos Aires, Argentina), a partir de registrar los cambios y laspermanencias que definen estos actores en la diversidad de sus actuaciones cotidianas.
PENGARUH VARIABEL SIKAP DALAM MEMODERASI HUBUNGAN PERTIMBANGAN MORAL TERHADAP MINAT MUZAKKI DALAM MEMBAYAR ZAKAT PROFESI (Studi Empiris di Kabupaten Ponorogo)
Authors: Ardianto Tri , A Tegoeh Hari , Sumarsono Hadi 
Published: September 2019

Penelitian ini bertujuan untuk mengetahui mengetahui pengaruh pertimbangan moral terhadap minat muzakki dalam membayar zakat profesi, mengetahui pengaruh sikap terhadap minat muzakki dalam membayar zakat profesi, dan mengetahui sikap dalam memperkuat pengaruh pertimbangan moral terhadap minat muzakki dalam membayar zakat profesi. Objek dalam penelitian ini adalah muzakki yang terdaftar di lembaga zakat wilayah Kabupaten Ponorogo yang sebelumnya telah ditentukan oleh peneliti. Jumlah sampel yang diambil adalah 100 responden dari seluruh lembaga yang telah dipilih yaitu LAZ Ummat Sejahtera Ponorogo, LAZIS Muhammadiyah Ponorogo dan Yatim Mandiri Ponorogo. Data dari hasil jawaban responden tersebut diolah dengan aplikasi Smart PLS 3. Hasil penelitian menunjukkan bahwa pertimbangan moral berpengaruh positif signifikan terhadap minat muzakki dalam membayar zakat profesi, sikap berpengaruh positif signifikan terhadap minat muzakki dalam membayar zakat profesi, akan tetapi variabel sikap gagal memoderasi hubungan antara pertimbangan moral terhadap minat muzakki dalam membayar zakat profesi.
Translation of Film Titles Based on Intercultural Communication
Authors: Qin Jing 
Published: September 2019

To illustrate cultural differences between China and the western world in translating film titles. Film industry plays a vital role in cultural communications, especially in the trend of globalization, which attaches a greater importance to film title translation than ever before. Some of theories concerning cultural differences will be discussed, including Hall's high-context and Low-context orientations and Hofstede's value dimensions. The study finds that with the help of these theories, certain translation methods can be utilized by translators in order to do a better job when translating titles of imported films.
Efeito da suplementação de probióticos por quatro semanas na resposta imune de pacientes infectados pelo HIV
Authors: Pedigoni Paula Miranda , Olegário Evelyn Gonçalves Garcia , Rossi Camila Manfredi Santos , Vassimon Helena Siqueira 
Published: September 2019

Introdução: Estudos observam que a suplementação com probióticos poderia retardar o dano, ou ajudar a preservar, o sistema imunológico em portadores do HIV. Objetivo: Avaliar o impacto da intervenção por quatro semanas com probióticos na melhora da função imunológica em portadores do HIV assintomáticos. Metodologia: Foi realizado estudo duplo cego randomizado com participação de 26 portadores do HIV assintomáticos em uso de terapia antirretroviral de alta potência (HAART). Onze indivíduos receberam os saches com probióticos que compõem as cinco principais cepas de microrganismos: Lactobacillusacidophilus, Lactobacillus casei, Lactococcuslactis, Bifidobacteriumbifidum, Bifidobacteriumlactis em quantidades 109 UFC/dia enquanto 15 indivíduos receberam placebo por 4 semanas. Contagem de células T CD4 e hábito intestinal foram avaliados. Resultados: Foi evidenciada diferença entre os grupos intervenção e placebo, ao demonstrar que houve aumento médio de 33 células/mm3 T CD4 no grupo intervenção e redução média no grupo placebo de 77 células/mm3(p < 0,05). Em relação ao hábito intestinal manteve-se regular em todos os participantes do início até final da pesquisa. Conclusão: A suplementação de probióticos por 28 dias pode auxiliar na melhora do sistema imune, retardando a diminuição de células T CD4 quando comparado ao grupo controle.