bluuebunny/crossref_metadata_2025_split huggingface dataset:
Description of male and habitat of Haroldius turnai Král (Coleoptera: Scarabaeidae: Scarabaeinae)
Authors: JIANG RI-XIN , XU YI-YANG , WANG SHUO 
Published: October 2019

The small-sized genus Haroldius Boucomont, 1914 consists of 38 known species widely distributed in the Old World including South Asia, Southeast Asia and West Africa (Pereira 1954; Krikken & Huijbregts 2006; Král & Hájek 2012). Members of this genus are probably saprophagous or mycophagous (Scheuern 1995) and so far were collected by light traps, sifted from leaf litter or soil and captured by flight interception traps (Paulian 1939; Paulian & Scheuern 1994; Krikken & Huijbregts 2006). Some researches suggested that they could have precise ecological relationship with ants. Their myrmecophily habit was indicated mainly by the special morphological characters including smooth body and the characteristically broad­ened and flattened tibiae (Pereira 1954; Krell & Philips 2010). However, their bi­ology are still rarely reported, and the larvae are still unknown (Pereira 1954; Krikken & Huijbregts 2006).
Observations of Extreme Short-Term Precipitation Associated with Supercells and Mesovortices
Authors: Nielsen Erik R. , Schumacher Russ S. 
Published: October 2019

Abstract
Extreme hourly rainfall accumulations (e.g., exceeding 75 mm h−1) in several noteworthy flash flood events have suggested that the most intense accumulations were attendant with discrete mesoscale rotation or rotation embedded within larger organized systems. This research aims to explore how often extreme short-term rain rates in the United States are associated with storm-scale or mesoscale vortices. Five years of METAR observations and three years of Stage-IV analyses were obtained and filtered for hourly accumulations over 75 and 100 mm, respectively, clustered into events, and subjectively identified for rotation. The distribution of the short-term, locally extreme events shows the majority of the events were located along the Atlantic and Gulf of Mexico coastlines with additional events occurring in the central plains and into the Midwest. Nearly 50% of the cases were associated with low-level rotation in high-precipitation supercells or mesoscale vortices embedded in organized storm modes. Rotation events occurred more clearly in the warm sector, while nonrotation events tended to occur along a surface boundary. The rotation events tended to produce higher hourly accumulations over a larger region, but were associated with somewhat stronger synoptic-to-mesoscale forcing for ascent and more total column moisture. These results support recent modeling results suggesting that rotationally induced dynamic vertical pressure perturbations should not be ignored when it comes to extreme precipitation and can potentially enhance the short-term rain rates.
Effects of dasatinib on CD8+T, Th1, and Treg cells in patients with chronic myeloid leukemia
Authors: Wei Xiaoqing , He Lin , Wang Xiaodong , Lin Min , Dai Jingying 
Published: October 2019

Objective To investigate the immunomodulatory effects of the tyrosine kinase inhibitor (TKI) dasatinib on T-cell subtypes in patients with chronic myeloid leukemia (CML). Methods T helper (Th) 1, Th2, regulatory T (Treg), and CD8+T cell levels were detected in patients with CML (n = 9) before and after dasatinib treatment. The corresponding response level at the time of a blood test was evaluated. Results After dasatinib treatment, six patients achieved a better response level, while three did not show improved response levels. Among the total nine patients, there were no significant differences in Th1, Th2, and Treg cell levels, whereas CD8+T cell levels were significantly increased after dasatinib treatment compared with before treatment. When we analyzed the six patients who obtained a better response level, Th1 and CD8+T cell levels were significantly increased after dasatinib treatment, but Th2 and Treg cell levels did not change. The other three patients who did not have improved response levels showed decreased Th1 cell levels and increased Treg cell levels after treatment. Conclusions Dasatinib may increase Th1 and CD8+T cell levels, and decrease Treg cell levels in patients with CML. This finding might be associated with a good therapeutic response to this drug.
Conducting systematic literature reviews and bibliometric analyses
Authors: Linnenluecke Martina K , Marrone Mauricio , Singh Abhay K 
Published: October 2019

Literature reviews play an essential role in academic research to gather existing knowledge and to examine the state of a field. However, researchers in business, management and related disciplines continue to rely on cursory and narrative reviews that lack a systematic investigation of the literature. This article details methodological steps for conducting literature reviews in a replicable and scientific fashion. This article also discusses bibliographic mapping approaches to visualise bibliometric information and findings from a systematic literature review. We hope that the insights provided in this article are useful for researchers at different stages of their careers – ranging from doctoral students who wish to assemble a broad overview of their field of interest to guide their work, to senior researchers who wish to publish authoritative literature reviews. JEL Classification: C18, C80, C88, M10, M20
Feasibility of Atrial Fibrillation Screening With Mobile Health Technologies at Pharmacies
Authors: Zaprutko Tomasz , Zaprutko Joanna , Baszko Artur , Sawicka Dominika , Szałek Anna , Dymecka Magdalena , Telec Wojciech , Kopciuch Dorota , Ratajczak Piotr , Michalak Michał , Rafał Dankowski , Szyszka Andrzej , Nowakowska Elżbieta 
Published: October 2019

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Thus, the aim of our study was to evaluate the smartphone-based electrocardiogram (ECG) recordings aimed at AF screening at Polish pharmacies. Methods: Prospective AF screening among patients aged ≥65 years was conducted at 10 pharmacies using Kardia Mobile with a dedicated application (Kardia app). Prior AF was a study exclusion criterion. CHA2DS2-VASc score (congestive heart failure, hypertension, age, diabetes mellitus, previous stroke/transient ischemic attack, female sex, and vascular disease) has been collected from every patient. A single-lead ECG has been acquired by the placement of fingers from each hand on the pads. Kardia app diagnosis has been evaluated by the cardiologist. Results: A total of 525 ECGs were performed. Kardia app diagnosis was provided in 490 cases. In 437 (89.18%) cases, it was “normal” rhythm, in 17 (3.47%) recordings “possible AF,” in 23 (4.69%) ECGs “unreadable,” and in 13 (2.65%) “unclassified”. After the cardiologist reevaluation, the new AF was identified in 7 (1.33%) patients. Sensitivity and specificity of Kardia app in detecting AF was 100% (95% confidence interval [CI]: 71.5%-100%) and 98.7% (95% CI: 97.3%-99.5%), respectively. The positive predictive value was 64.7% (95% CI: 38.3%-85.7%) and the negative predictive value was 100% (95% CI: 99.2%-100%). CHA2DS2-VASc score was 2.14 ± 0.69 for those with new AF and 3.33 ± 1.26 in the non-AF group. Conclusion: Kardia app is capable of fast screening and detecting AF with high sensitivity and specificity. The possible diagnosis of AF deserves additional cardiological evaluation. The results obtained in patients with low CHA2DS2-VASc score and “silent” AF confirm the importance of routine AF screening. Cardiovascular screening with the use of mobile health technology is feasible at pharmacies.
Impact of resistance training sets performed until muscular failure with different loads on intraocular pressure and ocular perfusion pressure
Authors: Vera Jesús , Jiménez Raimundo , Redondo Beatríz , Torrejón Alejandro , de Moraes Carlos Gustavo , García-Ramos Amador 
Published: October 2019

Purpose: The aim of this article is to investigate the acute effects of bench press sets leading to muscular failure with different loads on intraocular pressure and ocular perfusion pressure. Study design: A randomized experimental study. Methods: Seventeen physically active young men performed four resistance training sets of bench press to muscular failure against different relative loads (65% one-repetition maximum vs 75% one-repetition maximum vs 85% one-repetition maximum vs 95% one-repetition maximum). Intraocular pressure was measured before and immediately after the execution of each of the four sets, and ocular perfusion pressure was also assessed before and after physical effort. Results: We found that intraocular pressure increased after reaching muscular failure (p < 0.001, ƞ²= 0.52), being also dependent on the interaction load × point of measure (p < 0.001, ƞ²= 0.33). Our data demonstrated that higher intraocular pressure increases were found when participants performed the bench press exercise against heavier loads, showing statistical significance for the 75% one-repetition maximum (p = 0.020, d = –0.63, mean change = 0.9 mmHg), 85% one-repetition maximum (p = 0.035, d = –0.56, mean change = 1.4 mmHg), and 95% one-repetition maximum (p < 0.001, d = –1.36, mean change = 2.9 mmHg) relative loads. For its part, ocular perfusion pressure showed a reduction after exercise (p = 0.009, ƞ²= 0.35), being these changes independent on the load used. Conclusion: Bench press exercise leading to muscular failure provokes an acute intraocular pressure rise, with greater changes when heavier loads are used. Ocular perfusion pressure exhibited an acute reduction after exercise; however, its clinical relevance seems to be insignificant (lower to 4%). We argue that the use of heavy loads, when training to muscular failure, should be discouraged in order to avoid acute intraocular pressure fluctuations. Future studies should corroborate the generalizability of these findings in glaucoma patients.
Preoperative cephalic vein diameter and diabetes do not limit the choice of wrist radio-cephalic arteriovenous fistula
Authors: Hou Guocun , Yan Yonghong , Li Guangyi , Hou Yi , Sun Xiuli , Yin Na , Feng Guozhen 
Published: October 2019

Aim: To identify predictors that affect initial maturation of new wrist radio-cephalic arteriovenous fistula and evaluate the clinical effects of the ipsilateral mid-forearm radio-cephalic arteriovenous fistulas creation in the event of first wrist radio-cephalic arteriovenous fistula failure. Methods: We performed a retrospective review of all patients who underwent first wrist radio-cephalic arteriovenous fistula creation between September 2016 and May 2018. Currently, we prefer to re-create an ipsilateral mid-forearm radio-cephalic arteriovenous fistula when the first wrist radio-cephalic arteriovenous fistula fails. Predictors of successful radio-cephalic arteriovenous fistulas were identified using univariate and multivariate analyses. Kaplan–Meier survival analysis and log-rank test were used to calculate successful radio-cephalic arteriovenous fistula rates. Results: Univariate analysis showed that predictive factors for successful wrist radio-cephalic arteriovenous fistula include larger preoperative cephalic vein diameter ( p = 0.001) and non-diabetic kidney disease ( p = 0.007). Multivariate binary logistic regression analysis revealed cephalic vein diameter ⩾2 mm (odds ratio = 4.55, 95% confidence interval = (1.49–13.92), p = 0.008) and non-diabetic kidney disease (odds ratio = 4.22, 95% confidence interval = (1.38–12.88), p = 0.011) to be independent predictors for successful radio-cephalic arteriovenous fistula. We re-created ipsilateral mid-forearm radio-cephalic arteriovenous fistulas in 15 patients among the 21 failed wrist radio-cephalic arteriovenous fistulas; all these arteriovenous fistulas maintained clinical maturation following up for 1–2 years. Conclusion: Small cephalic vein diameter (<2 mm) and diabetes were independent risk factors for failed wrist radio-cephalic arteriovenous fistulas, but this risk could be overcome by aggressive ipsilateral mid-forearm radio-cephalic arteriovenous fistula to address a failed first attempt. Cephalic vein diameter is more important during the maturation stage, and once maturation has occurred, diabetes has an additive role in determining the patency of wrist radio-cephalic arteriovenous fistula. The “wrist RCAVF first, ipsilateral mid-forearm RCAVF second” strategy is the most clinically significant message of our study.
Same-Day Associations Between Substance Use and Medication Nonadherence Among Persons Living with HIV
Authors: Ramsey Susan E. , Ames Evan G. , Uber Julia , Habib Samia , Clark Seth , Waldrop-Valverde Drenna 
Published: October 2019

Objectives: To examine the same-day associations between substance use and objectively measured antiretroviral therapy (ART) nonadherence among persons living with HIV (PLWH). Methods: PLWH ( N = 53) were given an electronic pill box (EPB), and their ART adherence was monitored for 14 days. During a follow-up interview, participants were asked about any alcohol or drug use that occurred during those same 14 days. Results: Daily heavy drinking (⩾5 drinks for males and ⩾4 drinks for females) was associated with a nearly five times greater likelihood of same-day ART nonadherence (OR = 4.90, 95% CI = 1.79-13.36, P = .002). Further, drug use was associated with a nearly two times greater likelihood of ART nonadherence on the same day (OR = 1.80, 95% CI = 1.14-2.85, P = .012). Conclusions: These results highlight the importance of continuing to pursue interventions to effectively address heavy drinking and drug use among PLWH in order to improve ART adherence.
Mortality and Urological Complications After Open Groin Hernia Repair in Local, General, and Regional Anesthesia: A Nationwide Linked Register Study
Authors: Olsen J. H. H. , Andresen K. , Öberg S. , Mortensen L. Q. , Rosenberg J. 
Published: October 2019

Background and Aims: The choice of anesthesia method may influence mortality and postoperative urological complications after open groin hernia repair. We aimed to investigate the association between type of anesthesia and incidence of urinary retention, urethral stricture, prostate surgery, and 1-year mortality after open groin hernia repair. Materials and Methods: Data were linked from the Danish Hernia Database, the national patient register, and the register of causes of death. We investigated data on male adult patients receiving open groin hernia repair from 1999 to 2013 with either local anesthesia, regional anesthesia, or general anesthesia. In relation to the type of anesthesia, we compared mortality and urological complications up to 1 year postoperatively. We adjusted for covariates in a logistic regression assessing urological complications and with the Cox regression assessing mortality. Results: We included 113,069 open groin hernia repairs in local anesthesia, regional anesthesia, or general anesthesia. The risk of urinary retention adjusted for covariates was higher after both general anesthesia (adjusted odds ratio = 1.64, 95% confidence interval = 1.05–2.57, p = 0.031) and regional anesthesia (odds ratio = 2.99, 95% confidence interval = 1.67–5.34, p < 0.0005) compared with local anesthesia. The adjusted risk of prostate surgery was also higher for both general anesthesia (odds ratio = 1.58, 95% confidence interval = 1.23–2.03, p < 0.0005) and regional anesthesia (odds ratio = 1.90, 95% confidence interval = 1.40–2.58, p < 0.0005) compared with local anesthesia. Type of anesthesia did not influence 1-year mortality or the risk for urethral stricture. Conclusion: Patients undergoing open groin hernia repair in local anesthesia experience the lowest rate of urological complications and have equally low mortality compared with patients undergoing repair in general anesthesia or regional anesthesia.
Cluster randomised trials with different numbers of measurements at baseline and endline: Sample size and optimal allocation
Authors: Copas Andrew J , Hooper Richard 
Published: October 2019

Background/Aims: Published methods for sample size calculation for cluster randomised trials with baseline data are inflexible and primarily assume an equal amount of data collected at baseline and endline, that is, before and after the intervention has been implemented in some clusters. We extend these methods to any amount of baseline and endline data. We explain how to explore sample size for a trial if some baseline data from the trial clusters have already been collected as part of a separate study. Where such data aren’t available, we show how to choose the proportion of data collection devoted to the baseline within the trial, when a particular cluster size or range of cluster sizes is proposed. Methods: We provide a design effect given the cluster size and correlation parameters, assuming different participants are assessed at baseline and endline in the same clusters. We show how to produce plots to identify the impact of varying the amount of baseline data accounting for the inevitable uncertainty in the cluster autocorrelation. We illustrate the methodology using an example trial. Results: Baseline data provide more power, or allow a greater reduction in trial size, with greater values of the cluster size, intracluster correlation and cluster autocorrelation. Conclusion: Investigators should think carefully before collecting baseline data in a cluster randomised trial if this is at the expense of endline data. In some scenarios, this will increase the sample size required to achieve given power and precision.
The Determinants of Corporate Debt Maturity for NSE-Listed Corporates
Authors: Kalsie Anjala , Nagpal Aishwarya 
Published: October 2019

The maturity structure of corporate debt is one of the significant financing choices that a firm must make simultaneously while deciding how to finance its operational and investment decisions. Even though the capital structure is one of the scrutinized topics of interest in the area of corporate finance literature, there are scarce studies investigating corporate debt maturity—even less so in the context of emerging markets. The choice of a suitable debt maturity structure is extremely relevant for firms as it can enable them to avoid mismatch by aligning assets in line with liabilities, address agency related problems, sidestep the ill effects of cost of capital and signal about the firms’ earning quality and value. The study investigates the firm-specific and macroeconomic determinants that are significant for a debt maturity structure of Indian corporate firms. A sample of 29 non-financial firms listed on the National Stock Exchange during the period 2008–2016 was taken to test the hypothesis. Employing fixed effects panel data analysis, the study provides an empirical evidence that firm size, liquidity, asset maturity and base rate have significant effects on debt maturity choice in the Indian context, whereas tax effects, growth rate, firm quality and wholesale price index are not significantly related to the debt maturity structure. JEL Classification: C23, G20, G32
Establishment and application of a CRISPR–Cas12a assisted genome-editing system in Zymomonas mobilis
Authors: Shen Wei , Zhang Jun , Geng Binan , Qiu Mengyue , Hu Mimi , Yang Qing , Bao Weiwei , Xiao Yubei , Zheng Yanli , Peng Wenfang , Zhang Guimin , Ma Lixin , Yang Shihui 
Published: October 2019

Abstract

Background
Efficient and convenient genome-editing toolkits can expedite genomic research and strain improvement for desirable phenotypes. Zymomonas mobilis is a highly efficient ethanol-producing bacterium with a small genome size and desirable industrial characteristics, which makes it a promising chassis for biorefinery and synthetic biology studies. While classical techniques for genetic manipulation are available for Z. mobilis, efficient genetic engineering toolkits enabling rapidly systematic and high-throughput genome editing in Z. mobilis are still lacking.

Results
Using Cas12a (Cpf1) from Francisella novicida, a recombinant strain with inducible cas12a expression for genome editing was constructed in Z. mobilis ZM4, which can be used to mediate RNA-guided DNA cleavage at targeted genomic loci. gRNAs were then designed targeting the replicons of native plasmids of ZM4 with about 100% curing efficiency for three native plasmids. In addition, CRISPR–Cas12a recombineering was used to promote gene deletion and insertion in one step efficiently and precisely with efficiency up to 90%. Combined with single-stranded DNA (ssDNA), CRISPR–Cas12a system was also applied to introduce minor nucleotide modification precisely into the genome with high fidelity. Furthermore, the CRISPR–Cas12a system was employed to introduce a heterologous lactate dehydrogenase into Z. mobilis with a recombinant lactate-producing strain constructed.

Conclusions
This study applied CRISPR–Cas12a in Z. mobilis and established a genome editing tool for efficient and convenient genome engineering in Z. mobilis including plasmid curing, gene deletion and insertion, as well as nucleotide substitution, which can also be employed for metabolic engineering to help divert the carbon flux from ethanol production to other products such as lactate demonstrated in this work. The CRISPR–Cas12a system established in this study thus provides a versatile and powerful genome-editing tool in Z. mobilis for functional genomic research, strain improvement, as well as synthetic microbial chassis development for economic biochemical production.
Triple artemisinin-containing combination anti-malarial treatments should be implemented now to delay the emergence of resistance
Authors: White Nicholas J. 
Published: October 2019

Abstract
Resistance threatens all our currently available anti-malarial drugs. Triple artemisinin-containing combination anti-malarial treatments (TACTs) combine an artemisinin derivative with two slowly eliminated partner drugs. TACTs are undergoing large-scale trials. If they prove safe, well-tolerated and efficacious then they should be deployed. This is in order to protect and extend the useful therapeutic life of the current generation of anti-malarial drugs, which are so essential for malaria control and elimination.
On single-step HSS iterative method with circulant preconditioner for fractional diffusion equations
Authors: Zhu Mu-Zheng , Zhang Guo-Feng , Qi Ya-E 
Published: October 2019

AbstractBy exploiting Toeplitz-like structure and non-Hermitian dense property of the discrete coefficient matrix, a new double-layer iterative method called SHSS-PCG method is employed to solve the linear systems originating from the implicit finite difference discretization of fractional diffusion equations (FDEs). The method is a combination of the single-step Hermitian and skew-Hermitian splitting (SHSS) method with the preconditioned conjugate gradient (PCG) method. Further, the new circulant preconditioners are proposed to improve the efficiency of SHSS-PCG method, and the computation cost is further reduced via using the fast Fourier transform (FFT). Theoretical analysis shows that the SHSS-PCG iterative method with circulant preconditioners is convergent. Numerical experiments are given to show that our SHSS-PCG method with circulant preconditioners preforms very well, and the proposed circulant preconditioners are very efficient in accelerating the convergence rate.