bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation challenges of artificial intelligence (AI) in primary care: Perspectives of general practitioners in London UK
Authors: Razai Mohammad S. , Al-bedaery Roaa , Bowen Liza , Yahia Reem , Chandrasekaran Lakshmi , Oakeshott Pippa 
Published: November 2024

Introduction
Implementing artificial intelligence (AI) in healthcare, particularly in primary care settings, raises crucial questions about practical challenges and opportunities. This study aimed to explore the perspectives of general practitioners (GPs) on the impact of AI in primary care.

Methods
A convenience sampling method was employed, involving a hybrid workshop with 12 GPs and 4 GP registrars. Verbal consent was obtained, and the workshop was audio recorded. Thematic analysis was conducted on the recorded data and contemporaneous notes to identify key themes.

Results
The workshop took place in 2023 and included 16 GPs aged 30 to 72 of diverse backgrounds and expertise. Most (93%) were female, and five (31%) self-identified as ethnic minorities. Thematic analysis identified two key themes related to AI in primary care: the potential benefits (such as help with diagnosis and risk assessment) and the associated concerns and challenges. Sub-themes included anxieties about diagnostic accuracy, AI errors, industry influence, and overcoming integration resistance. GPs also worried about increased workload, particularly extra, unnecessary patient tests, the lack of evidence base for AI programmes or accountability of AI systems and appropriateness of AI algorithms for different population groups. Participants emphasised the importance of transparency, trust-building, and research rigour to evaluate the effectiveness and safety of AI systems in healthcare.

Conclusion
The findings suggest that GPs recognise the potential of AI in primary care but raise important concerns regarding evidence base, accountability, bias and workload. The participants emphasised the need for rigorous evaluation of AI technologies. Further research and collaboration between healthcare professionals, policymakers, and technology organisations are essential to navigating these challenges and harnessing the full potential of AI.
Gaga for MAGA: Nineties Nostalgia and Gay Reactionary Populism
Authors: Petronio Francesca 
Published: November 2024

Abstract
This article explores nostalgia for the not-so-queer nineties, or rather, what Amin Ghaziani called the “post-gay” nineties. Inspired by Rosalind Gill's “postfeminism as a sensibility,” I coin “post-gay as a sensibility” as I explore the affective dimensions of post-gay culture. As an example of post-gay politics, I dive into a critical study of Walk Away, a coming-out-as-conservative social movement. Sparked by a video testimonial and the hashtag #WalkAway, the movement documents the exodus of ex-Democrats who now ride the Trump train, with the goal of attracting liberals, and especially minorities, to the GOP. Assembling a bricolage of methodologies, I blend a discursive analysis of #WalkAway's online content and participant observation of the Walk Away LGBT town hall, as I explore how conservative influencers construct nostalgia for the nineties as a site of longing for a time before marriage equality, when there was a normative push to devote all movement energy toward political legibility and respectability. I focus on two elements of this constructed nostalgia: reliance on the political power of the coming-out ritual, and the supremacy of biological determinism over social constructivism.
Features of eyelid microcirculation in chronic mixed blepharitis and type 2 diabetes mellitus
Authors: Safonova T. N. , Zaitseva G. V. , Kintyukhina N. P. , Timoshenkova E. I. 
Published: November 2024

BACKGROUND: Microcirculatory dysfunction in patients with diabetes mellitus leads to tissue trophic insufficiency, reduction of adaptation reserves. It is possible to perform lifetime assessment of structural and functional changes in the microcirculation system by laser Doppler flowmetry. The presence of microcirculatory disorders is established in eyelids in chronic blepharitis and meibomian gland dysfunction. The article presents the results of the study concerning the peculiarities of neoangiogenesis as a mechanism of development of chronic blepharitis and meibomian gland dysfunction in diabetes mellitus (DM).AIM: to reveal the peculiarities of microcirculatory disorders of the eyelid in chronic mixed blepharitis in patients with type 2 diabetes mellitus (T2DM).MATERIALS AND METHODS: The study was conducted in 57 patients: 37 patients with chronic mixed bilateral blepharitis and a verified diagnosis of T2DM (group 1, n=74 eyes, average age 69.5 ± 7.5 years; subgroup 1a, n=38 eyes — patients with T2DM and glycated hemoglobin average level (HbA1с) 6.7±1.2; subgroup 1b, n=36 eyes — patients with T2DM and HbA1с average level 8.2±1.3) and 20 patients with chronic mixed bilateral blepharitis without signs of DM (group 2, n=40 eyes, mean age 67.2±4.3 years). Laser Doppler flowmetry was performed on the device «LAZMA MC-1».RESULTS: In patients with chronic blepharitis against the background of T2DM the development of ischemia of the eyelid tissue with increasing tension of functioning of the regulatory systems of microcirculation blood flow and lymph flow was detected, and in persons without DM — venous stasis with moderate inhibition of vasomotor, respiratory and dominance of cardiac oscillations of blood flow, as well as insufficiency of neurogenic oscillations of lymph flow. In this case in 1a subgroup the dominance of neurogenic oscillations of blood flow was revealed, in 1b - myogenic. Microcirculatory changes of lymph flow in the 1b subgroup were more pronounced in comparison with the 1a subgroup.CONCLUSION: The results proves the negative influence of T2DM on the microcirculatory bed of patients with chronic mixed blepharitis. The disorders detected by laser Doppler flowmetry vary depending on the HbA1с.
The introduction of new technologies for insulin therapy and glycemic control in clinical practice in the period 2016-2023, and their impact on achieving treatment targets in children with type 1 diabetes mellitus
Authors: Laptev D. N. , Knyazeva T. T. , Bezlepkina O. B. 
Published: November 2024

BACKGROUND: continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) improve daily life for people with Type 1 Diabetes Mellitus dramatically (T1D). However, there are still no compelling evidences that the use of insulin pumps (IP) and continuous glucose monitors (CGM) really help to improve diabetes control in children and adolescents.AIM: to analyze the relation between diabetes control and the use of insulin pumps and continuous glucose monitors in children.MATERIALS AND METHODS: 6382 children with T1D aged 1–18 years were enrolled in this study. Frequency of CSII and CGM use, HbA1с level and the percentage of children with HbA1с< 7.0% were analyzed.RESULTS: HbA1c decreased from 8.6% to 7.7% for 7 years (p<0.001). Simultaneously the quantity of children with HbA1c<7.0% increased from 11% to 29%. During this period the use of CGM increases dramatically from 11.6% to 84%. The use of IP increases from 38.7% to 42.3% (p<0.001).CONCLUSION: CSII and continuous glucose monitors use statistically significant improves T1D control in children according to mean HbA1c level decrease and the quantity of children with target HbA1c level increase.
Adaptation of The Diabetes Distress Scale on a Russian-speaking sample of patients with type 1 and type 2 diabetes mellitus
Authors: Likhodey N. V. , Epishin V. E. , Kalashnikova M. F. , Kaurova A. M. , Tulupova M. V. , Sych Y. P. , Bondareva I. B. 
Published: November 2024

BACKGROUND: Diabetes distress (DD) is the negative emotional or affective experience resulting from living with diabetes. DD is a negative predictor of blood glucose control and quality of life, and may lead to decreased adherence to treatment. To diagnose DD, questionnaires are used to screen the emotional state and psychosocial aspects. In the study, linguistic, cultural adaptation and assessment of the psychometric properties of the Russian version of the questionnaire “The Diabetes Distress Scale” were conducted among patients suffering from T1DM and T2DM.Patients with diabetes mellitus (DM) have diabetic distress as one of the most common mental disorders along with depression. Depression and diabetic distress increase the risk of death in diabetes, negatively affect treatment adherence and self-monitoring of glycemia. Identification of these conditions among patients with T1DM and T2DM can contribute to their timely correction.AIM: To carry out linguistic and cultural adaptation of the questionnaire “The Diabetes Distress Scale” and evaluate the psychometric properties of the Russian version of the DDS questionnaire on a Russian-speaking sample of patients with T1DM and T2DM.MATERIALS AND METHODS: A study was conducted on a sample of 198 patients with T1DM and T2DM; data was collected on the use of the Russian version was collected DDS scales, as well as the EQ-5D-5L (European Quality of Life Questionnaire), SPANE (Positive and Negative Experiences Scale) and HADS (Hospital Anxiety and Depression Scale) scales. The last three scales were used to assess the convergent validity of the adapted questionnaire. Reliability of the DDS questionnaire was assessed using Cronbach’s α coefficient of internal consistency and participant retest after 1–4 months.RESULTS: The factor structure of The Diabetes Distress Scale questionnaire is fully reproduced when all 17 questions are included (measurement model fit indicators: CFI=0.981, RMSEA=0.055, TLI=0.967). The internal consistency of the subscales (α ϵ [0.836; 0.874]) and the questionnaire as a whole (α=0.948) is assessed as high. Significant correlations of the adapted methodology and its subscales with the scales of the EQ-5D-5L, SPANE, HADS questionnaires were obtained, the closest connections (Rho ϵ [0.370; 0.437], p<0.01), which indicates good external validity of the adapted methodology.CONCLUSION: The Russian version of the DDS questionnaire has good psychometric properties. It is a valid and reliable tool for assessing diabetes distress among patients with T1DM and T2DM and can be recommended for use in clinical practice for timely diagnosing depression and DD.
Retrospective Analysis of the Characteristics of the Post-COVID Period in Patients with Type 2 Diabetes, Infected During Different Variant-Associated Periods of COVID-19
Authors: Altynbekova S. A. , Fadeev V. V. , Abilayuly Z. , Bolshakova S. V. 
Published: November 2024

BACKGROUND: Since the emergence of coronavirus infection in clinical practice, particular attention has been paid to its acute phase. However, to date, the direct and indirect impact on patients with type 2 diabetes mellitus after recovery from coronavirus infection remains an open question.OBJECTIVE: To determine the clinical and laboratory features of the post-COVID period in patients with type 2 diabetes mellitus during different phases of the infection.MATERIALS AND METHODS: A descriptive retrospective study was conducted using the electronic medical records of 134 patients who had recovered from coronavirus infection.RESULTS: The majority of the patients were women, with no significant differences in age and gender distribution across the groups (p=0.384 and p=0.207, respectively). During the «Omicron» period, there were fewer comorbidities and fewer hospitalized patients compared to the other groups (p<0.0167). Regarding diabetes-related conditions, frequent urination was observed only in patients during the «Alpha» period, while the frequency of hypoglycemia, hyperglycemia, the severity of chronic kidney disease, and manifestations of polyneuropathy did not differ significantly between the groups (p>0.0167). When examining newly diagnosed diseases, a statistically significant difference was found only in musculoskeletal disorders (16.7% in «Alpha» vs. 30.2% in «Delta» vs. 3.7% in «Omicron», p=0.015). In the analysis of laboratory indicators, a difference was detected in platelet counts and activated partial thromboplastin time (APTT): median platelet counts were significantly lower in the «Alpha» and «Delta» groups compared to the «Omicron» group (210 [179.2–249.7] x10⁹/L and 218 [196.5–281] x10⁹/L vs. 255 [208–327] x10⁹/L, respectively, p=0.016). The APTT was significantly longer for «Alpha» and «Delta» compared to «Omicron» (28 [23.6–31.3] seconds vs. 30.3 [26.1–34.9] seconds vs. 27.1 [22.4–30.3] seconds, respectively, p=0.013).CONCLUSION: Real-world data allow tracking the development of new symptoms and diseases in patients during the post-COVID period. Patients with type 2 diabetes mellitus during the «Omicron» variant-associated period had a lower risk of developing new symptoms and diseases. It is necessary to implement solutions for monitoring target HbA1c levels through medical information systems and to enhance reporting standards for patient symptoms to enable more accurate analysis Real world data (RWD).
Application of leaf multispectral analyzer in comparison to hyperspectral device to assess the diversity of spectral reflectance indices in wheat genotypes
Authors: Filacek Andrej , Zivcak Marek , Barboricova Maria , Kovar Marek , Halabuk Andrej , Gerhatova Katarina , Yang Xinghong , Hauptvogel Pavol , Brestic Marian 
Published: November 2024

Abstract
Multispectral devices have a huge potential to be utilized in biological, ecological, and agricultural studies, providing valuable information on plant structure and chemical composition. The aim of the study was to assess the reliability and sensitivity of the affordable leaf spectrometer PolyPen (PP) in comparison with the highly sensitive analytical device FieldSpec-4. Measurements at the leaf level were realized on a collection of 24 diverse field-grown wheat (Triticum sp. L.) genotypes in several growth phases during the regular growing season, focusing on whole spectral curves and a set of 41 spectral reflectance indices. As expected, the sensitive analytical device showed a higher capacity to capture genotypic variability and the ability to distinguish seasonal changes compared to a low-cost multispectral device. Nevertheless, the analysis of the data provided by low-cost sensors provided a group of parameters with good sensitivity, including reasonable correlations between the records of the two devices (r > 0.80). Based on the large obtained datasets, we can conclude that the application of a low-cost PP leaf spectrometer in plant and crop studies can be efficient, but the selection of parameters is crucial. Thus, the present study provides valuable information for users of affordable leaf spectrometers in fundamental and applied plant science.
Lights and Shadows of the Tez Tour Decision: A Step Forward in Consumer/Traveller Protection Amid New Uncertainties
Authors: Cioni Andrea 
Published: November 2024

Abstract
The decision of the European Court of Justice in M D v Tez Tour UAB addresses four different questions and provides further insight into the concept of ‘unavoidable and extraordinary circumstances’ under Article 12(2) of Directive (EU) 2015/2302. This judgment certainly strengthens the protection of consumer travellers by extending the scope of the provision. However, as this contribution highlights, the decision also introduces several elements of uncertainty that are likely to cascade into domestic litigation and generate lively debate among academics. The most critical issue is undoubtedly the relationship between the average and the vulnerable consumer/traveller.
EU Digital Private Law: Tattering or New Beginning?
Authors: Domurath Irina , Micklitz Hans-W. 
Published: November 2024

Abstract
This article analyses the impact of the digital acquis on the regulation of market relations governed by private law. The hypothesis is that a new EU digital private law is emerging that deconstructs the existing EU private law acquis and paves the way for an emergent constitutional order of digital private law, which has three distinct levels. The three levels of the EU digital order broaden the scope of digital private law to ever more addressees and establish distinct modes of private law and models of justice. While on the constitutional level, no particular mode of private law is established, at the levels of market ordering and horizontal transactions respectively we find contracts and advertisements on the one hand and contract law on the other as the specific modes of private law. There are also differences with regard to the model of justice they establish, reaching from access justice and non-discrimination to freedom from manipulation and substantive fairness. As a result of this three-levelled analysis, it becomes possible to identify breakdowns and extensions of concepts, as well as the emergence of and interactions between different modes of private law governance and justice.
RGB-to-hyperspectral conversion for accessible melanoma detection: A CNN-based approach
Authors: Bsharat Sondos Mahmoud , Abouelnour Sana , Ahmed Ragad , Elkhatib Mariam , Gaber Sama , Shehieb Wessam , Arshad Kamran , Assaleh Khaled 
Published: November 2024

Abstract
One major difficulty facing the healthcare industry is the early and precise detection of melanoma. With its capacity to record a broad spectrum of electromagnetic wavelengths, hyperspectral imaging (HSI) is a promising technique for accurate melanoma diagnosis. However, the limited accessibility of HSI technology prevents it from being widely used. This article introduces a novel method for converting readily available red green blue (RGB) images to their hyperspectral counterparts using convolutional neural networks (CNNs). Through this conversion process, spectral information is improved, enabling a more thorough examination to detect melanoma. Principal component analysis (PCA) aids the machine learning algorithm in differentiating between melanoma and healthy moles in the classification model. Accuracy is significantly increased when spot detection and PCA are combined; Naïve Bayes achieves 76% accuracy in this way. These models are used in the developed web-based program SkinScan for real-time melanoma analysis, providing a useful and accessible solution. This work emphasizes how CNN-driven RGB-to-HSI conversion might improve melanoma detection accuracy and accessibility.
Partial purification and characterization of Echinococcusgranulosus antigen 5, extracted from hydatid cyst: Radiolabeling study with Iodine 125
Authors: Hadj Rabia Samia , Zaouani Mohamed , Boudjellaba Sofiane , Zahnit Wafa , Grib Hocine , Raache Rachida , Zeghir-Bouteldja Razika , Alouache Mounia , Brahimi Abdelkarim , Messaoudi Mohammed 
Published: November 2024

Abstract
Cystic echinococcosis is a parasitic disease caused by the development of the larval form (hydatid cyst) of Echinococcus granulosus sensu lato (s.l) in humans and herbivores. In this study, antigen 5 (Ag 5), recognized as the major and most immunogenic fraction of E. granulosus (s.l), was partially purified using ammonium sulfate precipitation at 70 % saturation and characterized by physicochemical and immunological methods. Analysis of the supernatant resulting from the precipitation showed typical mobility for antigen 5. The antigen produced a single precipitation arc when tested against a pool of sera from patients and rabbits immunized with this antigen. A band of approximately 66 kDa was observed through SDS-PAGE under denaturing conditions. Radiolabeling of the antigen with iodine-125 (I125) achieved a yield of 63 % with a radiochemical purity of 92.6 %. In evaluating antigenic integrity, a tolerable non-specific binding of 16 % was observed, alongside satisfactory specific binding of 60 % when tested with rabbit anti-fraction 5 serum. These preliminary results are promising and will be further refined to determine optimal conditions for preparing a high-quality tracer, which could be valuable in the diagnosis of hydatid disease.
Numerical analysis of brush seal hysteresis based on orthogonal test method
Authors: Xiao Furen , Kang Yuchi , Wang Yuanlun , Kao-Walter Sharon 
Published: November 2024

Abstract
By the finite element analysis software ABAQUS, utilizing General Contact and Contact damping algorithm, the brush seal hysteresis numerical model with pressure differential considered was established. The hysteresis was quantified by the hysteresis energy, and the hysteresis energy and maximum stress are obtained by numerical calculations. An orthogonal test was conducted to study the effects of bristle diameter, bristle cant angle, fence height, bristle length, upstream and downstream differential pressure, and rotor radial displacement on the hysteresis and maximum stress of the brush seal. Results show that the primary and secondary orders of parameters affecting hysteresis are: rotor radial displacement, bristle diameter, upstream and down-stream differential pressure, bristle cant angle, bristle length, and fence height. The primary and secondary orders of parameters affecting maximum stress are: upstream and downstream differential pressure, fence height, bristle cant angle, bristle diameter, bristle length, and rotor radial displacement. Finally, based on the numerical results, a fitted correlation was developed. Comprehensive effects of the six parameters on both performances were analyzed, and structural design optimization methods focusing on single performance and comprehensive performance were proposed, providing references for the design of brush seals in practical engineering applications.
Stoische Doxographie in der Ethik des Clemens von Alexandrien
Authors: Kirsch-Klingelhöffer Charlotte 
Published: November 2024

Abstract
Clement of Alexandria provides extensive material on Greek philosophy in his Paedagogos and his Stromata. As it was part of contemporary philosophical debate, both works include so called doxographies listing the opinions (doxai) of philosophers about certain topics. In this article, I will show how Clement takes up ethical doxographies concerning the Stoic definition of the καθῆκον (“duty”) in Paedagogos 1,13,101 and the τέλος (the “highest end”) in Stromata 2,19,100–101 and 2,21,129. Comparing them to other doxographical sources (Diogenes Laertius, Arius Didymus), it becomes obvious, that Clement gradually transforms and restructures these philosophical doxai to lead his readers to a Christian understanding of ethics.
State of the art in low-temperature and high-temperature electrolysis
Authors: Ayers Katherine E. , Marina Olga A. 
Published: November 2024

AbstractWater electrolysis is gaining traction in large-scale applications, with production of multiple technologies scaling to hundreds and thousands of megawatts of new electrolyzer capacity annually. Low-temperature electrolysis has dominated the electrolyzer market for decades, but still only represents a small amount of the overall hydrogen market, due to the higher production costs versus hydrogen derived from fossil fuels. Advances are needed in capital cost and efficiency to close the cost gap, especially for energy applications. Similarly, while high-temperature electrolyzers can operate more efficiently, reducing the operating cost, they still need further scale-up and cost reduction to compete in these markets. Understanding the recent advances in each and the priority research directions is important to focus and accelerate innovation, and will be discussed in this article. The different advantages and disadvantages of each of these technologies will also be reviewed; there will likely be applications for each in the overall deployment of renewable hydrogen.
Graphical abstract