bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of clinical outcomes of drug-coated balloons angioplasty vs. plain old balloons angioplasty for peripheral arterial disease: an umbrella meta-analysis
Authors: Li Jiacheng , Lu Wei , Lin Lihong , Wu Jiawen , Cheng Guobing , Hu Qiang , Guo Yi 
Published: November 2024

BackgroundPeripheral artery disease (PAD) affects millions globally, causing significant morbidity. Traditional treatments like plain old balloon angioplasty (POBA) have limited success due to high restenosis rates. Drug-coated balloon angioplasty (DCBA) has emerged as a promising alternative, locally delivering antiproliferative drugs like paclitaxel to reduce restenosis. However, the clinical outcomes of DCBA compared to POBA remain inconsistent across various studies.ObjectiveThis umbrella meta-analysis aimed to compare the clinical outcomes of DCBA and POBA in PAD patients, synthesizing data from multiple meta-analyses to provide a more robust evidence base.MethodsWe conducted an umbrella meta-analysis following PRISMA guidelines, systematically reviewing Cochrane Library, Embase, PubMed, and Web of Science. Studies were included if they compared DCBA and POBA in PAD patients, focusing on primary outcomes such as target lesion revascularization (TLR), primary patency (PP), all-cause mortality (ACM), and amputation. Secondary outcomes included restenosis, late lumen loss (LLL), and major adverse events (MAE).ResultsSixteen meta-analyses were included. DCBA significantly reduced the risk of TLR (OR: 0.41, 95% CI: 0.34–0.49), PP was significantly higher in DCBA (OR: 2.05, 95% CI: 1.53–2.75), and restenosis was lower (OR: 0.46, 95% CI: 0.41–0.51). No significant differences were found in ACM or amputation risk between the two groups. Heterogeneity was moderate to high across most outcomes.ConclusionDCBA provides significant advantages over POBA in reducing TLR and restenosis while maintaining vessel patency. However, the effects on ACM and amputation remain inconclusive. Future research should focus on long-term safety and identifying which patient subgroups benefit most from DCBA.Systematic Review Registrationhttps://www.crd.york.ac.uk/, PROSPERO [CRD42024591967].
Research on microseismic source location based on time quality constraints
Authors: Wu Xuefei , Xie Qian , Yan Junsheng 
Published: November 2024

IntroductionTo develop a small-scale regional microseismic location model for coal mines and enhance the accuracy of microseismic location at the bottom plate,this article proposes a high-precision location algorithm for 3D-Fast Sweeping Method (3D-FSM) seismic sources under time quality constraints.MethodsThe study investigates the numerical simulation of microseismic location accuracy on coal seam floor, considering various observation systems, arrival time picking errors, and wave velocity discrepancies. The algorithm employs a VGG-16 deep learning network to train and establish a quality control model for P-wave pickup values; Next, utilizing the 3D-FSM framework, it calculate the seismic wave travel time field and applies Fermat’s principle for each detection point, as well as the reversible principle of elastic wave propagation path. This allows for the determination of the spatial path and travel time from any potential source point to the detection point. Finally, the algorithm scans each computational node, using the controlled travel time difference to identify the source point corresponding to the smallest spatial node.ResultsThe results indicate that the location error of the borehole tunnel observation system is smaller than that of the tunnel observation system. Specifically, with the borehole tunnel observation system, the variance in P-wave arrival time picking is 1 ms, and the wave velocity variance is 20 m/s2, demonstrating high accuracy.DiscussionThe findings suggest that the 3D-FSM seismic source location algorithm, under quality control, approaches the precision of manual location methods and exhibits high reliability, even when disregarding significant accuracy errors during the quality control location process.
Exploring causal associations between interleukins, their receptors, and acute respiratory distress syndrome: a bidirectional-Mendelian Randomization study
Authors: Ma Jia-wei , Tang Ji-chun , Fang Hong-zhi 
Published: November 2024

BackgroundAcute Respiratory Distress Syndrome (ARDS) is a severe lung condition posing significant health risks. Observational studies have indicated a potential linkage between ARDS and various interleukins, such as Interleukin-8, −2, −6, and −1β. However, the causal relationships between specific interleukins, their receptors, and ARDS remain unclear.MethodsThis study employed bidirectional Mendelian Randomization (MR) to investigate the causal associations between 197 different interleukins, interleukin receptors, and ARDS. GWAS summary data for interleukins and their receptors were sourced from publicly available studies, while ARDS data were derived from the FinnGen database. Wald Ratio and Inverse Variance Weighted (IVW) methods were primarily utilized in the MR analyses. Reverse MR was also conducted to explore reverse causations.ResultsThe study identified significant causal relationships between several interleukins, their receptors and ARDS. Specifically, Interleukin-17 receptor D (IL-17RD) (OR = 0.67, 95%CI = 0.51–0.89, p = 0.006), Interleukin-22 receptor subunit alpha-1 (IL22RA-1) (OR = 1.45, 95%CI = 1.08–1.96, p = 0.014), Interleukin-20 receptor subunit alpha (IL20RA) (OR = 0.53, 95%CI = 0.32–0.89, p = 0.016), Interleukin-22 (IL-22) (OR = 3.60, 95%CI = 1.20–10.83, p = 0.022), Interleukin-23 receptor (IL-23R) (OR = 2.14, 95%CI = 1.10–4.17, p = 0.025), Single Ig IL-1-related receptor (SIGIRR) (OR = 1.22, 95%CI = 1.00–1.48, p = 0.047) showed notable associations with ARDS. No reverse causal relationships were found on results above, and neither heterogeneity nor pleiotropy was detected in the analysis.ConclusionThis study elucidates the causal connections between specific interleukins, their receptors and ARDS, contributing significantly to the understanding of ARDS pathogenesis. These findings offer a foundation for further research and potential therapeutic interventions targeting these interleukins and receptors in ARDS management. The absence of reverse causation and pleiotropy, heterogeneity reinforces the robustness of these associations.
Women's empowerment and current contraceptive use in Pakistan: informed by theory of gender and power
Authors: Kumari Bhavita , Do Mai , Madkour Aubrey Spriggs , Wisniewski Janna Marie 
Published: November 2024

IntroductionIt is evident from the stagnant modern contraceptive rate and the growing population of Pakistan that the family planning (FP) programs in Pakistan have failed to deliver successfully. The study examines the association of domains of women's empowerment, following the Theory of Gender and Power, with the current use of contraceptive methods and how intimate partner violence (IPV) can moderate such associations in Pakistan.MethodsMarried women of reproductive age from the Pakistan DHS (2017–18) were included in the analysis (n = 14,502). Key independent variables were identified using Connell's Theory of Gender and Power operationalized by Wingood and DiClemente, and constructs were created using principal component analysis. Multinomial logistic regressions were conducted to assess the relationships of the three empowerment divisions (i.e., sexual division of labor, sexual division of power, and cathexis), to the current use of contraceptives.ResultsWhen all empowerment domains were included in the model along with covariates, education (sexual division of labor), sex negotiations (sexual division of power), and husband's fertility intentions (cathexis) remained significant in their associations with modern contraceptive use.ConclusionThis is the first study in Pakistan to examine multi-faceted empowerment, applying Connell's theory of gender and power to identify key domains associated with contraceptive use. A multi-prong approach to FP programs that aims to improve specific domains of women's empowerment and to increase FP service use may be more likely to succeed than stand-alone programs.
Dietary seaweed extract mitigates oxidative stress in Nile tilapia by modulating inflammatory response and gut microbiota
Authors: Siddik Muhammad A. B. , Francis Prue , Foysal Md Javed , Francis David S. 
Published: November 2024

IntroductionExtreme water temperature affects the well-being of all aquatic animals, including fish. Higher temperatures can lead to the generation of reactive oxygen species (ROS), which can induce oxidative stress and negatively impact fish health and well-being. This study investigated the protective effects of seaweed extract on growth, antioxidant status, inflammatory responses, and gut microbiota to gain a better understanding of the acclimatization ability of Nile tilapia, Oreochromis niloticus in response to oxidative stress caused by high water temperatures.MethodsRed-seaweed, Gracilaria tenuistipitata rich in polyphenols (i.e., total phenolics and flavonoids content) was considered for the preparation of the Gracilaria extract (GE) for the study. Nile tilapia were fed the GE supplemented diet along with a control diet for 42 days, followed by 14 days of temperature ramping at a rate of 1°C every two days to the desired target (35°C) and 14 days of holding at 32°C for acclimatation.ResultsNile tilapia fed the GE had a significantly higher growth performance attributed to increased muscle fiber size compared to control (p &lt; 0.05) after the 70 days of feeding trial. Fish fed the GE diet also showed a significantly lower lipid peroxidation by decreased malondialdehyde level when compared to control (p &lt; 0.05). Furthermore, GE diet exhibited increased red blood cell counts with the decreased number of cellular and nuclear abnormalities. The gene expression of tight junction (i.e., occludin, claudin1, ZO-1) and nrf2 (antioxidant biomarker) were upregulated, while hsp70 (related to stress response) was downregulated in fish fed the GE diet. Additionally, GE supplementation led to an increase in bacterial diversity and the abundance of phylum Firmicutes, order Lactobacillales, and genera Sphingobacterium and Prevotella in the distal gut of Nile tilapia, which are mostly considered as beneficial for fish.ConclusionThe findings suggest that GE has the potential to be used as a dietary supplement to improve health, particularly as a stress-resistant supplement in the diet for Nile tilapia. This study may help make more informed decisions for tailoring the nutrient requirements of fish in the face of climate warming.
Allopregnanolone and mood in the peripartum: a longitudinal assessment in healthy women
Authors: Grötsch Maria Katharina , Ehlert Ulrike 
Published: November 2024

BackgroundAllopregnanolone (ALLO), a neuroactive steroid hormone derived from progesterone, can modulate mood via the GABA-A receptor. Peripartum mood can be influenced by psychosocial factors, previous mental illness, and hormonal changes. Studies suggest a U-shaped effect of ALLO on mood, with some women being more sensitive to hormonal changes than others. However, research in the peripartum is inconclusive.MethodsThis study explored the link between salivary ALLO and mood during the peripartum. Over 12 weeks, N = 61 women completed the Edinburgh Postnatal Depression Scale and the State Anxiety subscale from the State–Trait Anxiety Inventory and provided saliva samples. Salivary ALLO was analyzed using an enzyme-linked immunosorbent assay, validated for saliva samples. Group-based trajectory modeling was performed to identify trajectories of ALLO courses. Multinomial logistic regression models were employed to identify risk factors associated with these trajectories.ResultsALLO levels increased during pregnancy and dropped 2 weeks before delivery. Three different trajectory groups of ALLO courses emerged (high decreasing, low moderate, low reduced). Trajectory groups were associated with distinct psychological risk factors, including previous mental illness, adverse childhood experiences, sleep problems, premenstrual symptoms, and resilience. The peripartum ALLO course showed a negative linear association with anxiety symptoms and a U-shaped association with depressive symptoms.DiscussionThe consideration of individual ALLO courses can predict the risk for peripartum mood symptoms, particularly among women with preexisting risk factors. While the majority of women remain healthy during the peripartum transition, analyzing ALLO subgroups helps to provide a better understanding of the relationship between ALLO and peripartum mood.
A phase II study evaluating safety and efficacy of niraparib in patients with previously treated homologous recombination defective metastatic esophageal/gastroesophageal junction/proximal gastric adenocarcinoma
Authors: Khalid Ahmed Bilal , Fountzilas Christos , Burney Heather N. , Mamdani Hirva , Schneider Bryan P. , Fausel Christopher , Perkins Susan M. , Jalal Shadia 
Published: November 2024

IntroductionEsophageal adenocarcinoma (EAC) remains a devastating disease and second line treatment options in the metastatic space are limited. Homologous recombination (HR) defects have been described in EAC in up to 40% of patients. Poly (ADP-ribose) polymerase (PARP)1 and PARP2 inhibitors have shown efficacy in HR defective prostate and ovarian cancers. Here, we describe the activity of the PARP inhibitor niraparib in metastatic EAC with HR defects.MethodsIn this single arm Simon two-stage Phase II study, we assessed the safety and efficacy of niraparib in patients with metastatic EAC previously treated with platinum containing chemotherapy harboring defective HR. Defective HR was defined as deleterious alterations in the following HR genes: BRCA1/2, PALB2, ATM, BARD1, BRIP1, CDK12, CHEK2, FANCA, RAD51, RAD51B, RAD51C, RAD51D, RAD54L, NBN, ARID1A and GEN1.Results14 patients were enrolled in this study. The trial was stopped early due to slow accrual. 3 patients did not have post-treatment scans because of rapid clinical decline. The overall response rate (ORR) (95% exact CI) was 0/11 = 0% (0%, 28.49%). The disease control rate (DCR) (95% exact CI) was 2/11 = 18.2% (2.3%, 51.8%). The median PFS was 1.8 months (95% CI = 1.0-3.7). The median OS for evaluable patients was 6.6 months (95% CI =2.7-11.4) and 5.7 months for all patients (95% CI =2.7-10.1). The most common adverse events seen were anemia, fatigue, and thrombocytopenia.ConclusionIn patients with metastatic EAC, single agent niraparib as second line therapy is not an effective option.
Efficacy and safety of anti-angiogenic drugs combined with chemotherapy in the treatment of platinum-sensitive/resistant ovarian cancer: a meta-analysis with trial sequential analysis of randomized controlled trials
Authors: He Haining , Zhou Fei 
Published: November 2024

BackgroundWith the emergence of new anti-angiogenic treatments and the ongoing updates to clinical guidelines, the effectiveness and safety of these agents in treating platinum-sensitive/resistant ovarian cancer (OC) are yet to be fully determined. Therefore, we conducted a meta-analysis to evaluate the efficacy and safety of anti-angiogenic drugs combined with chemotherapy (CT) for platinum-sensitive OC (PSOC) or platinum-resistant OC (PROC).MethodsA comprehensive literature search was conducted across several databases, including PubMed, Web of Science, Embase, and the Cochrane Library, encompassing all pertinent randomized controlled trials (RCTs) up to 31 May 2024. The primary outcomes for the meta-analysis were progression-free survival (PFS) and overall survival (OS), while the objective response rate (ORR), adverse events (AEs) of any grade, and grade ≥3 AEs were considered secondary endpoints. Data synthesis involved the computation of hazard ratio (HR), relative risk (RR), along with their 95% confidence interval (CI) and prediction interval (PI). Trial sequential analysis was carried out using STATA 12.0, R software 4.3.1, and TSA v0.9.5.10 Beta software.ResultsThis meta-analysis encompassed 15 RCTs. The overall analysis revealed that compared to CT alone (or plus placebo), anti-angiogenic drugs combined with CT significantly improved PFS (HR [95% CI] = 0.573 [0.518–0.633], 95% PI: 0.383-0.876) and ORR (RR [95% CI] = 1.362 [1.260–1.472], 95% PI: 0.824–2.251), but also increased the incidence of grade ≥3 AEs (RR [95% CI] = 1.115 [1.070–1.162], 95% PI: 0.870–1.422) in PSOC patients. For PROC patients, this combination therapy notably improved PFS (HR [95% CI] = 0.542 [0.475–0.619], 95% PI: 0.322–0.930), OS (HR [95% CI] = 0.752 [0.646–0.875], 95% PI: 0.554-0.997), and ORR (RR [95% CI] = 2.141 [1.702–2.694], 95% PI: 0.839–5.307), whilst simultaneously elevating the risk of grade ≥3 AEs (RR [95% CI] = 1.487 [1.216–1.819], 95% PI: 0.755–2.828).ConclusionOur research verified the advantages of combining anti-angiogenic agents with CT in enhancing PFS and ORR for patients with PSOC, and also confirmed improvements in PFS, OS, and ORR for those with PROC. It is crucial for medical practitioners to remain alert to the potential occurrence of AEs when implementing this combined therapeutic approach in a clinical milieu.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024552010.
Effects of administering berberine alone or in combination on type 2 diabetes mellitus: a systematic review and meta-analysis
Authors: Wang Jiacheng , Bi Chenhao , Xi Hongbin , Wei Fengqin 
Published: November 2024

BackgroundDespite the availability of multiple therapies for Type 2 diabetes mellitus (T2DM), challenges remain due to side effects and efficacy limitations. Berberine (BBR) has shown broad anti-diabetic effects, prompting a systematic assessment of its efficacy and safety through a meta-analysis.MethodsA comprehensive search was conducted across eight database and search engines from inception until 06/09/2024. Only randomized controlled trials (RCTs) meeting inclusion criteria were analyzed. The Cochrane risk of bias assessment tool and Jadad scale were used to evaluate study quality. Meta-analysis was performed using RevMan v5.3 and Stata/SE v15.1.ResultsFifty studies involving 4,150 participants were included. BBR alone significantly reduced fasting plasma glucose (FPG) (MD = −0.59 mmol/L, p = 0.048), 2-h postprandial blood glucose (2hPBG) (MD = −1.57 mmol/L, p &lt; 0.01), low-density lipoprotein cholesterol (LDL-C) (MD = −0.30 mmol/L, p &lt; 0.01), total cholesterol (TC) (MD = −0.30 mmol/L, p = 0.034), and triglycerides (TG) (MD = −0.35 mmol/L, p &lt; 0.01). When combined with hypoglycemic drugs, BBR significantly improved FPG (MD = −0.99 mmol/L, p &lt; 0.01), 2hPBG (MD = −1.07 mmol/L, p &lt; 0.01), glycated hemoglobin (HbA1c) (MD = −0.69%, p &lt; 0.01), and other metabolic markers, including fasting insulin (Fins), homeostasis model assessment index for assessing insulin resistance (HOMA-IR), lipid profiles and inflammatory markers. The most common BBR dosage was 0.9–1.5 g/d, with treatment cycles typically lasting 1–3 months.ConclusionCurrent evidence suggests that BBR alone or in combination has significant potential for treating type 2 diabetes mellitus (T2DM). Future research should encompass a broader scope, including not just the beneficial effects of BBR in head-to-head studies, but more crucially, delving into its mechanisms of action with hypoglycemic drugs to optimize T2DM treatment strategies.
Identification, screening, and comprehensive evaluation of novel thrombin inhibitory peptides from the hirudo produced using pepsin
Authors: Chai Xiaoyu , Pan Fulu , Wang Qianqian , Wang Xinyu , Li Xueyan , Qi Dongying , Yi Zirong , Liu Huan , Zhang Jing , Zhang Yiming , Pan Yanli , Liu Yang , Wang Guopeng 
Published: November 2024

PurposeThe inhibition of thrombin has proven to be an efficacious therapeutic approach for managing cardiovascular disease (CVD), with widespread implementation in clinical settings. Oral ingestion of peptides and protein drugs is influenced by gastrointestinal digestive enzymes. We aimed to evaluate the thrombin inhibitory properties of hirudo hydrolysates (HHS) produced by pepsin and propose a comprehensive approach to screen and evaluate thrombin inhibitors.MethodsWe evaluated the in vitro inhibitory properties of the hirudo extract, both before and after hydrolysis with pepsin, toward thrombin. We screened for the most potent thrombin inhibitory peptide (TIP) using nano liquid chromatography-tandem mass spectrometry (Nano LC-MS/MS) coupled with in silico analysis. Next, we employed the thrombin inhibition activity IC50 to investigate the interaction between TIP and thrombin, and conducted in vitro evaluations of its anticoagulant effects (APTT, TT, PT), as well as its ability to inhibit platelet aggregation. Furthermore, we utilized UV-Vis spectroscopy to explore structural changes in thrombin upon binding with TIP and employed molecular dynamics simulations to delve deeper into the potential atomic-level interaction modes between thrombin and TIP.ResultsThe retention rate of thrombin inhibition for HHS was found to be between 60% and 75%. A total of 90 peptides from the HHS were identified using LC-MS/MS combined with de novo sequencing. Asn-Asp-Leu-Trp-Asp-Gln-Gly-Leu-Val-Ser-Gln-Asp-Leu (NDLWDQGLVSQDL, P1) was identified as the most potent thrombin inhibitory peptide after in silico screening (molecular docking and ADMET). Then, the in vitro study revealed that P1 had a high inhibitory effect on thrombin (IC50: 2,425.5 ± 109.7 μM). P1 exhibited a dose-dependent prolongation of the thrombin time (TT) and a reduction in platelet aggregation rate. Both UV-Vis spectroscopy and molecular dynamics simulations demonstrated that P1 binds effectively to thrombin.ConclusionOverall, the results suggested that HHS provides new insights for searching and evaluating potential antithrombotic compounds. The obtained P1 can be structurally optimized for in-depth evaluation in animal and cellular experiments.