bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategi Promosi Wisata Melalui Push Notification Smart Tourism Berbasis PWA di Pemandian Teluk Sibayan
Authors: Iqbal Muhammad , Rohminatin Rohminatin , Syahputra Abdul Karim , Indriani Meliya , Khairani Alya Fauza 
Published: November 2024

The "CITRA" Hot Spring in Teluk Sibayan, Batu Bara Regency, North Sumatra, holds significant potential as a tourist destination. However, the main challenges faced by the management include a lack of digital promotion, limited tourist visits from outside the region, and a shortage of human resources skilled in using information and communication technology (ICT). The community service project by the STMIK Royal Faculty aimed to address these issues through mentoring, training, and technology development. The methods employed included workshops and training on digital tourism promotion, the creation of a web-based ticketing application, and a smart tourism application based on Progressive Web Apps (PWA) with push-notification features. Additionally, social media accounts on Instagram and Facebook (@sibayan.pemandian) were established as online promotion platforms. The results of this initiative indicate an improvement in the staff’s capacity to utilize technology, along with the provision of digital systems that streamline visitor management and promotion efforts. As a result, Pemandian Citra now has stronger digital infrastructure to support tourism promotion and attract more visitors.Keywords: community service; hot springs; PWA; smart tourism; promotion Abstrak: Pemandian Air Panas "CITRA" di Teluk Sibayan, Kabupaten Batu Bara, Sumatera Utara, memiliki potensi besar sebagai destinasi wisata. Namun, permasalahan utama yang dihadapi pengelola adalah kurangnya promosi digital, minimnya kunjungan wisatawan dari luar daerah, serta keterbatasan sumber daya manusia dalam menggunakan teknologi informasi dan komunikasi (TIK). Kegiatan pengabdian masyarakat oleh Tim Dosen STMIK Royal bertujuan untuk mengatasi masalah ini melalui pendampingan, pelatihan, dan pengembangan teknologi. Metode yang digunakan mencakup workshop dan pelatihan terkait promosi wisata digital, pembuatan aplikasi tiket berbasis web, serta aplikasi smart tourism berbasis Progressive Web Apps (PWA) dengan fitur push-notification. Selain itu, akun media sosial Instagram dan Facebook dengan nama pengguna @sibayan.pemandian juga dibuat sebagai sarana promosi online. Hasil dari kegiatan ini menunjukkan peningkatan kapasitas staf pemandian dalam memanfaatkan teknologi, serta penyediaan sistem digital yang mempermudah pengelolaan kunjungan dan promosi. Dampaknya, Pemandian Citra kini memiliki infrastruktur digital yang lebih kuat untuk mendukung promosi wisata dan meningkatkan daya tarik bagi wisatawan..Kata kunci: Pengabdian Masyarakat; Pemandian Air Panas; PWA; Smart Tourism; Promosi
Bimbingan dan Pelatihan Membuat Pembukuan Keuangan Berbasis Digital pada UMKM Batik Kantil Malang
Authors: Ita Rifiani Pertamasari  , Lilies Nur Aini  , Umi Khabibah  , Fullchis Nurtjahjani  , Jatrifia Ongga Sinatriya  , Yulis Nurul Aini  , Ane Fany Novitasari  
Published: November 2024

Pembukuan keuangan atau sistem akuntansi pada usaha kecil menengah dalam skala terkecil sekalipun mutlak dibutuhkan walaupun banyak pengusaha konvensional menganggapnya sebagai hal yang merepotkan. Dengan bantuan perkembangan teknologi, kini pencatatan keuangan dapat dilakukan dengan komputerisasi. UMKM Batik Kantil Malang masih menghadapi permasalahan pencatatan keuangan secara manual sehingga kualitas pencatatan keuangan pada usaha tersebut belum baik. Tujuan dari kegiatan ini adalah memberikan bimbingan dan pelatihan pencatatan keuangan dengan aplikasi Microsoft Excel. Sasaran kegiatan ini adalah karyawan UMKM Batik Kantil Malang dengan menggunakan metode ceramah, tutorial, diskusi dan latihan. Kegiatan pembinaan ini dilakukan untuk membina serta melatih para pelaku UMKM dalam menganalisa transaksi-transaksi secara nyata hingga proses penyusunan laporan keuangan

Kata kunci: Pencatatan, Keuangan, Microsoft Excel
Dual-phase SilMA hydrogel: a dynamic scaffold for sequential drug release and enhanced spinal cord repair via neural differentiation and immunomodulation
Authors: Zhang Ruizhi , Zhang Mingzhe , Chen Lu , Jiang Linlin , Zou Chenbo , Li Na , Zhou Hengxing , Feng Shiqing 
Published: November 2024

IntroductionSpinal cord injury (SCI) is a severe central nervous system disorder that results in significant sensory, motor, and autonomic dysfunctions. Current surgical techniques and high-dose hormone therapies have not achieved satisfactory clinical outcomes, highlighting the need for innovative therapeutic strategies.MethodsIn this study, we developed a Dual-Phase Silk Fibroin Methacryloyl (SilMA) hydrogel scaffold (DPSH) that incorporates PLGA microspheres encapsulating neurotrophin-3 (NT-3) and angiotensin (1-7) (Ang-(1–7)). The DPSH is designed for temporally controlled release of therapeutic agents to reduce inflammation during the acute phase of SCI and to promote neuronal differentiation and axonal regeneration in later stages.ResultsComprehensive characterization of the DPSH revealed a highly porous architecture, suitable mechanical properties for spinal cord tissue, and stability unaffected by the incorporation of microspheres and drugs. In vitro studies demonstrated that Ang-(1–7) significantly induced M2 microglia polarization by 1.8-fold (p &lt; 0.0001), effectively reducing inflammation. Additionally, NT-3 enhanced neural stem cell differentiation into neurons by 3.6-fold (p &lt; 0.0001). In vivo experiments showed that the DPSH group exhibited significantly higher Basso Mouse Scale (BMS) scores (p &lt; 0.0001), enhanced motor function, reduced astrocyte scarring by 54% (p &lt; 0.05), and improved neuronal survival and regeneration.DiscussionThese findings underscore the therapeutic potential of the DPSH scaffold for SCI repair, presenting a novel strategy to enhance neural recovery through a combination of immunomodulation and neuroprotection.
Complicated mycotic saccular aneurysm of the infra-renal abdominal aorta with infected retroperitoneal hematoma: a clinical case report
Authors: Chinaliyev A. M. , Jussubaliyev Y. I. , Khassenov D. T. , Sabyruly D. , Shaimerden E. M. , Kapyshev M. S. , Aleushinov R. I. , Aitkul S. Sh. , Yessenbayeva G. A. , Sagandykov I. N. , Sultanaliyev T. A. 
Published: November 2024

BackgroundRupture of an abdominal aortic aneurysm (AAA) is a life-threatening emergency, with untreated cases nearing a 100% mortality rate. This case presents a rare complication of AAA rupture with an infected retroperitoneal hematoma, emphasizing the importance of timely diagnosis and a multidisciplinary approach.Case presentationA 59-year-old male presented with lower back pain, fever, and difficulty moving, persisting for three weeks. Imaging revealed a saccular infra-renal AAA rupture with an infected retroperitoneal hematoma. Emergency surgery included extracorporeal subclavian-femoral bypass and aneurysm resection. Despite intraoperative complications, the patient recovered after 16 days in intensive care and was discharged in satisfactory condition. Follow-up CT one month later showed functioning bypasses and clinical improvement.ConclusionThis case illustrates the critical need for early diagnosis and coordinated surgical intervention in complex AAA ruptures complicated by infection. Timely multidisciplinary treatment is crucial to prevent further complications and improve patient outcomes.
Early paleozoic evolution of the South Bainaimiao Ocean: constraints from the Chegendalai ophiolite mélange
Authors: Feng Chenfei , Wang Guosheng , Zhou Zhiguang , Gao Shen , Chen Jianfeng , Hu Hao 
Published: November 2024

IntroductionArc-continent collision contributes to the accretion of continental crust in the Central Asian Orogenic Belt. The Chegendalai ophiolitic mélange, located between the Bainaimiao arc and the North China Craton, is important to understanding the early Paleozoic evolution of the South Bainaimiao Ocean and arc-continent collision processes.MethodsIn this study, we provide Early Paleozoic geochronological and geochemical data from the Chegendalai ophiolitic mélange and island arc magmatic rocks in northern Damaoqi.ResultsZircon U-Pb dating of ultrabasic rocks and diabase porphyrite from the Chegendalai ophiolitic mélange yielded ages of 424 Ma and 431.9 Ma, respectively. Schist has an age of 421 Ma. Zircon U-Pb ages of island arc magmatic rocks are 425.7 Ma for tonalite, and 431 ± 11 Ma and 433.2 ± 4.4 Ma for granodiorite. Gabbro and ultrabasic rocks were formed in a volcanic arc basalt or mid-ocean ridge setting, displaying a tholeiitic basalt signature. These rocks likely derived from the lithospheric mantle with assimilation of crustal materials. Intermediate-acid magmatic rocks in northern Damaoqi are geochemically classified as I-type granites and exhibit characteristics of adakites.DiscussionThese rocks formed by partial melting of subducted plates and interactions with crustal and mantle wedges in a volcanic arc setting. Based on these results, we propose a three-stage evolution model for the South Bainaimiao Ocean: (i) Initial subduction during the Ordovician (∼450 Ma), where the Bainaimiao arc separated the South Bainaimiao Ocean from the PaleoAsian Ocean, with the former acting as a branch ocean basin of the latter; (ii) Northward subduction from the Ordovician to Late Silurian (450–424 Ma), with the South Bainaimiao Ocean subducting northward. The subducted slab partially melted and interacted with the crust-mantle wedge, leading to the formation of subduction-related island arc magmatic rocks; (iii) Closure during the Late Silurian (424–421 Ma), marked by the collision of the Bainaimiao arc with the North China Craton in an arc-continent collision, ending orogenesis with the Xibiehe Formation.
The harmful effect of ankylosing spondylitis on diabetes mellitus: new evidence from the Mendelian randomization analysis
Authors: Ren Zheng , He Liang , Wang Jing , Shu Li , Li Chenyang , Ma Yuan 
Published: November 2024

BackgroundWhile observational research has highlighted a possible link between ankylosing spondylitis (AS) and type 2 diabetes (T2DM), the quality of evidence remains limited, and the causal relationship is yet to be established. This study aims to explore the causal link between AS and T2DM, as well as its impact on traits related to glucose metabolism.MethodTo infer a causal relationship between AS and various diabetes-related traits, including type 1 diabetes (T1DM), T2DM, blood glucose levels, fasting glucose, glycated hemoglobin, and fasting insulin, we employed Mendelian randomization (MR) analysis. We sourced GWAS summary data for both exposure and outcome variables from the IEU OpenGWAS database, GWAS Catalog, and FinnGen database. To synthesize the results of the MR analyses, we applied meta-analysis techniques using either a fixed or random effects model. For identifying and excluding instrumental variants (IVs) that exhibit horizontal pleiotropy with the outcomes, we utilized the MR-PRESSO method. Sensitivity analyses were conducted using the MR-Egger method, along with Q and I^2 tests, to ensure the robustness of our findings.ResultsOur analysis revealed a significant association between AS and an increased risk of T1DM with an odds ratio (OR) of 1.5754 (95% CI: 1.2935 to 1.9187) and T2DM with an OR of 1.0519 (95% CI: 1.0059 to 1.1001). Additionally, AS was associated with elevated levels of fasting glucose (beta coefficient = 0.0165, 95% CI: 0.0029 to 0.0301) and blood glucose (beta coefficient = 0.0280, 95% CI: 0.0086 to 0.0474), alongside a decrease in fasting insulin levels (beta coefficient = -0.0190, 95% CI: -0.0330 to -0.0050).ConclusionOur findings collectively underscore the detrimental impact of AS on the development of diabetes, highlighting the critical influence of autoimmune disorders in diabetes onset. This provides profound insights into the pathogenesis of diabetes from an immunological standpoint.
Exploring the association between muscle mass and thyroid function in Chinese community subjects over 45 years old with normal thyroid function: a cross-sectional analysis
Authors: Zhu Zaisheng , Qian Yidan , Ding Pan , Jin Kejia , Chen Junpeng , Fu Jiayue , Zhao Hongjun , Chen Chengshui , Chen Junjie 
Published: November 2024

BackgroundCurrently, nothing is known about the connection between muscle mass and thyroid hormone levels in middle-aged and elderly Chinese with normal thyroid function. The purpose of this study was to determine the potential association between muscle mass and thyroid function status in middle-aged and elderly Chinese subjects with normal thyroid function.MethodsA cohort of 1868 participants in China were included in this retrospective study; their mean age was 53.97 years, and their skeletal muscle mass index was 7.44 kg/m2. Of them, 60.97% were men. Thyroid hormone concentrations, standard biochemical indices, and the frequency of chronic illnesses were among the many factors that were evaluated. Bioelectrical impedance analysis (BIA) was used to assess the patients’ body composition. The skeletal muscle index (SMI) was calculated using the following formula: SMI = ASM (kg)/height 2 (m2), where ASM stands for appendicular skeletal muscle mass. To identify the correlations between the variables, the Spearman correlation coefficient was used. Binary logistic regression analysis was conducted to investigate the potential linkages between thyroid hormone levels and diminished muscle mass.ResultsIn this investigation, a significant correlation was observed between low muscle mass and FT3/FT4 (OR=0.044, 95% CI: 0.004–0.440, P=0.008), as well as FT3 (OR=0.697, 95% CI: 0.508–0.957, P=0.025). Conversely, no discernible correlation trend was detected with TSH (OR=0.972, 95% CI: 0.814–1.160, P=0.753) and FT4 (OR=1.97, 95% CI=0.983–1.224, P=0.1). Following adjustment for various confounding factors, including age, vitamin D levels, triglycerides, HDL-C, LDL-C, total protein, hypertension, diabetes, hyperuricemia, and overweight/obesity, across the entire study population, a positive correlation between SMI and FT3/FT4 was identified. Subsequent gender, age, and weight-stratified analyses revealed consistent correlation trends between SMI and FT3/FT4, with all interactions yielding P-values &gt; 0.05.ConclusionOur study has revealed that among middle-aged and elderly Chinese individuals exhibiting normal thyroid function, a reduction in the free T3 to free T4 ratio is associated with a decline in muscle mass.
Waist circumference, among metabolic syndrome components, predicts degraded trabecular bone score: a retrospective study of a female population from the 2005-2008 NHANES cohorts
Authors: Totaro Maria , Barchetta Ilaria , Sentinelli Federica , Cimini Flavia Agata , Palazzi Sara , D’Alessandro Francesco , Spagnolo Luca , Dule Sara , Barbonetti Arcangelo , Cavallo Maria Gisella , Baroni Marco Giorgio 
Published: November 2024

BackgroundOsteoporosis and metabolic syndrome (MetS) are conditions associated with ageing and chronic inflammation; among MetS’ components, visceral obesity has been correlated to low bone mineral density in postmenopausal women. However, data on an increased fracture risk in MetS are still contrasting. The trabecular bone score (TBS) is an indicator of bone quality and a potential predictive factor for fractures. We aim to explore the relationship between MetS components and TBS.Methodswe analyzed data from 3962 women in the 2005-2006 and 2007-2008 NHANES cohorts, for whom a valid TBS value was available. All analyses were adjusted for the principal risk factors of altered bone metabolism.ResultsAn inverse significant association was observed between TBS and most of the MetS variables investigated, with the strongest correlation found with waist circumference (WC) (P &lt;0.001). WC represented the major predictor of degraded TBS (P &lt;0.001), in adjusted models considering age, 25(OH)Vitamin D, smoke and insulin resistance. Increased WC was significantly associated with the presence of bone fractures at the logistic regression analysis (P = 0.001) in all study participants and in the subgroup of women ≤50 years old after adjustment for potential confounders (P = 0.006).ConclusionThis study, using a large sample of women, found a negative association of MetS on bone health, mainly driven by visceral obesity.
Clinical characteristics and biomarkers of severe immune checkpoint inhibitor-related pneumonitis triggered by immunotherapy followed by radiation: a case report
Authors: Zhu Yan , Yu Jianhe , Ren Qun , Wu Xiang , Xu Hongxia , Tian Tian , Liu Jiang 
Published: November 2024

BackgroundThe advent of immune checkpoint inhibitors (ICIs) has revolutionized the treatment landscape for tumor patients, dramatically improving survival rate. However, patients treated with immunotherapy are inevitably at risk of immune-related adverse events (irAEs). Immune checkpoint inhibitor-related pneumonitis (ICI-P) is an important type of IrAEs with a potentially lethal risk, which should be given more attention. Diagnosis and timely treatment of ICI-P is challenging due to the lack of specificity of its clinical and radiological features. Besides, poor understanding of biological mechanisms of ICI-P has led to a lack of reliable biomarkers to identify patients at risk, limiting timely treatment and proper management of it.Case presentationWe presented longitudinal clinical features and successful treatment experience in a metastatic esophageal squamous cell carcinoma (ESCC) patient treated with immunochemotherapy followed by palliative radiotherapy for cervical lymph nodes who developed severe pneumonitis outside of the radiation field ten days after completion of radiotherapy suggestive of ICI-P. In addition, analysis of circulating biomarkers demonstrated an increase in platelet-to-lymphocyte ratio (PLR) and platelet-to-monocyte ratio (PMR), as well as the levels of CD4+T and CD8+T cells that tracked with the progression of ICI-P, and then decreased with corticosteroid treatment.ConclusionsOur data highlight the imaging manifestations associated with ICI-related pulmonary toxicity and describe the dynamics of the corresponding circulating markers. Although our results reveal that dynamic monitoring of PLR and PMR as well as the levels of CD4+T and CD8+T cells may predict the risk of ICI-P, further investigations are needed to elucidate the underlying molecular and biological mechanisms for better management of ICI-P.
Bridging the educational gaps of health professionals in oncogenomics: results from a pilot e-learning course
Authors: Stellacci Emilia , Martinelli Simone , Carbone Pietro , Demuru Elena , Genuardi Maurizio , Ghiorzo Paola , Novelli Giuseppe , Di Pucchio Alessandra , Regini Federica Maria , Guerrera Debora , Vittozzi Andrea , Barbina Donatella , Venanzi Serenella , van den Bulcke Marc , Boccia Stefania , Mazzaccara Alfonso , De Nicolo Arcangela , De Angelis Roberta 
Published: November 2024

BackgroundGenetic and genomic literacy of health professionals is of utmost importance to realize the full potential of personalized medicine. As part of a European Union project, we piloted an e-learning course on oncogenomics, primarily targeted to physicians, and we assessed both its effectiveness and users’ satisfaction.MethodsThe course materials were developed in English according to the Problem-Based Learning method. Learning objectives, covering the basic principles of genetics and the OMICS technologies applied to oncology, were defined based on previously identified core competencies. We used a pre-test vs. post-test study design to assess knowledge improvements. Performance results by demographic and professional characteristics of participants were analyzed using univariate or multivariate statistical methods.ResultsOverall, 346 Italian professionals (61% physicians, 39% biologists) successfully completed the course. Their average post-test score was almost 19% higher than the pre-test (71.6% vs. 52.9%), with no significant differences by sex. Older age (&gt;50 years) and southern area of residence were both correlated with higher gains. The average proportion of correct answers in the final certification test after three attempts was 85% (69% at first attempt), with some differences across professional categories. Methodology, quality of content and usability of the e-learning platform were all highly rated via satisfaction questionnaire (average scores between 4 and 5, scale 1 to 5).ConclusionThe pilot phase confirmed the suitability of the e-learning as a cost-effective method to improve oncogenomic literacy of health professionals. Translation into natural languages and accreditation by European or country-specific Continuing Medical Education systems will be the main incentives for wider dissemination.
The value of off-pump coronary artery bypass grafting in the surgery for combined valvular and coronary heart disease
Authors: Qin Haokai , Si Pengrui , Hua Kun , Yang Xiubin 
Published: November 2024

BackgroundCombined valve and coronary surgery is a commonly performed surgical technique for treating coexisting valvular and coronary artery disease. This study aims to investigate the effect of reducing the duration of cardiopulmonary bypass by utilizing the off-pump coronary artery bypass grafting (OPCABG) technique on the short-term prognosis of patients.MethodsIn this retrospective cohort study, 884 patients were divided into groups undergoing OPCABG or on-pump CABG combined with valve surgery based on the CABG technique. We evaluated the relationship between the surgical technique and operative mortality, postoperative atrial fibrillation (POAF), stroke, acute kidney failure (AKI), and perioperative myocardial infarction. Propensity score matching and inverse probability weighting (IPTW) were employed to mitigate differences in baseline characteristics between the two groups.ResultsThe incidence of POAF and AKI were lower in the OPCABG group after IPTW (POAF: 29.5% vs. 39.5%, p = 0.016; AKI: 14.5% vs. 21.2%, p = 0.047). OPCABG technique was independently associated with the POAF (adjusted OR: 0.63, 95% CI: 0.44–0.91, p = 0.014) and AKI (adjusted OR: 0.63, 95% CI: 0.39–0.98, p = 0.049). These results remained even following PSM and IPTW analyses.ConclusionThe OPCABG technique is associated with reduced occurrences of POAF and AKI in patients undergoing valve and concomitant coronary surgery and can be safely used.