bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased survival due to lower toxicity for high‐risk T‐cell acute lymphoblastic leukemia patients in two consecutive pediatric‐inspired PETHEMA trials
Authors: Barba Pere , Morgades Mireia , Montesinos Pau , Gil Cristina , Fox María‐Laura , Ciudad Juana , Moreno María‐José , González‐Campos José , Genescà Eulàlia , Martínez‐Carballeira Daniel , Martino Rodrigo , Vives Susana , Guardia Ramon , Mercadal Santiago , Artola María‐Teresa , Cladera Antonia , Tormo Mar , Esteve Jordi , Bergua Juan , Vall‐Llovera Ferran , Ribera Jordi , Martínez‐Sanchez Pilar , Amigo María‐Luz , Bermúdez Arantxa , Calbacho María , Hernández‐Rivas Jesús‐Maria , Feliu Evaristo , Orfao Alberto , Ribera Josep‐María 
Published: September 2018

AbstractObjective and methodsPediatric‐inspired regimens have been adopted by several groups as the treatment strategy for adult patients with acute lymphoblastic leukemia (ALL). Whether subsequent modifications of these protocols have led to an improvement in the outcome of patients is uncertain, especially in T‐cell ALL. We analyzed 169 patients with high‐risk T‐cell ALL included in two consecutive trials of the PETHEMA Group (HR‐ALL03 [n = 104] and the more contemporary HR‐ALL11 [n = 65]).ResultsPatients and disease characteristics were balanced between both groups. Regarding efficacy, we observed a similar complete remission (CR) rate, relapse and disease‐free survival (DFS) between both protocols. Patients included in the HR‐ALL11 trial had better 2‐year overall survival (OS) compared with the HR‐ALL03 (65% [95% CI 51%‐79%] vs 44% [95% CI 34%‐54%],P = 0.026). Regarding toxicity, we observed a better safety profile in the HR‐11 protocol. Irrespective of the protocol, patients with good measurable residual disease (MRD) clearance had a promising outcome without allogeneic hematopoietic stem cell transplantation (allo‐HSCT) in CR1, with 2‐year OS of 67%.ConclusionPatients with T‐cell ALL included in the HR‐11 trial showed better OS than patients in the HR‐03, mostly driven by a reduction of NRM.
Influence of sintering temperature on the morphology of ceramic hollow fibers prepared from niobium pentoxide
Authors: Ferreira Eduardo de Paulo , Bessa Lidiane Pereira , Cardoso Vicelma Luiz , Reis Miria Hespanhol Miranda 
Published: September 2018

AbstractCeramic hollow fibers were prepared by the phase inversion and sintering method using niobium pentoxide (Nb2O5) as an innovative starting material. X‐ray diffraction and Raman analyses revealed the same monoclinic crystalline phase for the ceramic material, H‐Nb2O5, at all the evaluated sintering temperatures. According to SEM images, the starting material was composed of polydisperse particles of irregular size and shape with sizes ranging from 12.5 to 89.7 μm. The increase in the sintering temperature caused particles agglomeration. In the hollow fiber precursor (without sintering), Nb2O5 grains were surrounded by the coagulated polymer. The polymeric phase was eliminated when the fibers were sintered at temperatures above 600°C. When sintered at 1350°C, the outer surface of the fiber presented elongated crystals of well‐defined shape, while agglomerated round shape grains were observed at the inner surface of the fiber. Formation of these elongated crystals was probable due to the material sintering at high temperatures (up to 1350°C) for more than 300 minutes. This study demonstrated the potential for general applicability of niobium pentoxide to fabricate ceramic hollow fiber membranes.
Phenomenological modeling of phase transitions and electrocaloric effect in Ba(Zr0.2Ti0.8)O3‐(Ba0.7Ca0.3)TiO3
Authors: Du Bingfeng , Ma Wenhui 
Published: September 2018

AbstractBa(Zr0.2Ti0.8)O3‐x(Ba0.7Ca0.3)TiO3 (BZT‐xBCT) is a promising lead‐free ferroelectric system. In this paper, we present two sets of free energy coefficients and carry out phenomenological modeling to study the phase transition and electrocaloric effect. The calculated phase diagram is in excellent quantitative agreement with experiments. Furthermore, we propose a new method based on effective internal electric field to simulate polarization in the macroscopic paraelectric state of ferroelectric relaxor. The computed composition and temperature‐dependent entropy and temperature change induced by electrocaloric effect are in good agreement with the measured data available for single crystal.
Correlates of population genetic differentiation in marine and terrestrial environments
Authors: Schiebelhut Lauren M. , Dawson Michael N 
Published: September 2018

AbstractAimTheory predicts that differences in phylogeographic structure between species should be related to differences in life history, environment, and evolutionary time. Reviews of empirical studies suggest sometimes complex interactions and possibly a preponderance of exceptions to the predicted relationship that greater population genetic differentiation results from lower dispersal potential, as a function of life history. We apply an analytical framework, which controls for effects of environment and time, to test the hypothesis that contrasts in population genetic differentiation are proportional to contrasts in life history traits.LocationGlobal.MethodsWe conducted a meta‐analysis using contrasts of life history traits and population genetic differentiation between synchronously diverging codistributed (SDC) taxa. Because SDC taxa experienced the same environment at the same time, the effects of time and environment are effectively controlled when analysing other causes of genetic differentiation within SDC taxa. This offers the opportunity to rigorously test whether traits favouring greater dispersal potential—such as fecundity, census population size, and duration of the dispersive stage—do lead to lower population genetic differentiation.ResultsWe find a strong inverse relationship between dispersal potential and population genetic differentiation, consistent with predictions. SDC species pairs with similar dispersal potential show similar population genetic differentiation; species with higher dispersal potential have lower population genetic differentiation, relative to species with lower dispersal potential.Main conclusionsSDC comparisons provide a rigorous method for disentangling the factors driving patterns of genetic differentiation in the marine and nonmarine realms. We found broad support for the relationship that higher dispersal potential is associated with lower population genetic differentiation, the specifics of which can be influenced by place, time, and taxon. This relationship appears to be stronger on land than in the sea. However, many factors influence population genetic structure; deviations in measured versus predicted population genetic differentiation may indicate the influence of drift or selection. Too often, too many factors go unmeasured, constraining our ability to disaggregate dispersal syndromes and fully resolve the influence of specific life history characteristics on gene flow.
Antihypertensive treatment and renal protection: Is there a J‐curve relationship?
Authors: Viazzi Francesca , Leoncini Giovanna , Grassi Guido , Pontremoli Roberto 
Published: September 2018

A bidirectional relationship between hypertension and kidney disease, with one exacerbating the effect of the other, is well established. Elevated blood pressure (BP) is a well‐recognized, modifiable risk factor for cardiovascular (CV) disease as well as for development and progression of chronic kidney disease and, therefore, the identification of optimal BP target is a key issue in the management of renal patients. Recent large trials and real life cohort studies have indicated that below a definite BP value renal protection seems to plateau and too low levels may even be associated with a paradoxical increase in renal morbidity, thus reviving the debate about the so called BP ‐renal function J‐curve relationship. Existing evidence supports a systolic target around 130 mm Hg to combine both renal and CV protection and possibly lower levels in the presence of overt proteinuria.
Developmental diet irreversibly shapes male post‐copulatory traits in the neriid fly Telostylinus angusticollis
Authors: Macartney Erin L. , Nicovich Philip R. , Bonduriansky Russell , Crean Angela J. 
Published: September 2018

AbstractNutrient availability has been shown to influence investment in many fitness‐related traits, including male reproductive success. Many studies have demonstrated that a reduction in nutrient availability alters male post‐copulatory trait expression, with some studies demonstrating an effect of developmental nutrients and others, an effect of adult nutrients. However, few studies have manipulated both developmental and adult nutrients in the same experiment. Therefore, it is not clear what life‐stage has the greatest effect on post‐copulatory trait expression, and if the effects of developmental and adult nutrients can interact. Here, we investigate effects of developmental and adult nutrition on male testes and accessory gland size, sperm movement within the female reproductive tract and sperm length in the neriid fly, Telostylinus angusticollis. We found that males fed a nutrient‐poor developmental diet produced sperm with a reduced tail beat frequency and had smaller testes and accessory glands compared to males fed a nutrient‐rich developmental diet. In contrast, we found no effects of adult nutrition on any traits measured, although sperm length was correlated with body size and male age but unaffected by nutrition at any stage. Therefore, investment in adult post‐copulatory traits is determined early on by developmental nutrients in male neriid flies, and this effect is not altered by adult nutrient availability.
A study on the color distribution of natural teeth by age and gender in the Korean population with an intraoral spectrophotometer
Authors: Kim Hee‐Kyung 
Published: September 2018

AbstractObjectiveTo investigate the distribution of natural tooth shades by age and gender in the Korean population with a spectrophotometer.Material and MethodsA total of 674 human subjects were recruited and divided into three age groups; young (16‐30), middle (31‐59), and elderly (60‐89). Each group was then subdivided according to gender. Color was measured on the upper central incisor and CIELab color coordinates were obtained. CIEDE2000 color differences (
ΔE00) between genders within each age group and between age groups for both genders were calculated. Two‐way analysis of variance (ANOVA) was used to identify the influence of age and gender on each color variable.ResultsThe most frequent color in the Korean population was 2L1.5. L* values decreased, while b* values increased with age (P < .05). There was a significant interaction between gender and age on b* values; F (2668) = 3.489, P = .031, partial η2 = 0.010, and observed power = 0.652. Females generally have lighter and less chromatic central incisors compared to males. The
ΔE00 values between genders in elderly groups were beyond acceptability threshold.ConclusionsThe central incisors were getting darker, more yellowish, and reddish with age. Information on the chromatic range of natural teeth by age and gender could help to select colors for esthetic dental restorations.Clinical SignificanceDentists should consider an unacceptable color mismatch between the restorations and natural dentition that can occur over time.
REF6 promotes lateral root formation through de‐repression of PIN1/3/7 genes
Authors: Wang Xiaolei , Gao Jiong , Gao Shan , Li Zhongpeng , Kuai Benke , Ren Guodong 
Published: September 2018

SummaryThe H3K27 methyltransferase CLF inhibits lateral root (LR) formation through depositing the repressive H3K27me3 mark to the chromatin of PIN1, a key polar auxin transporter gene. Here, we show that the H3K27me3 demethylase REF6 promotes lateral root primordium initiation and LR emergence. REF6 directly binds to the chromatin of PIN1/3/7. Dysfunction in REF6 results in increased levels of H3K27me3 on PIN1/3/7 and suppressed expression of PIN genes. Genetic analysis of the clf ref6 double mutant revealed an antagonistic action between CLF and REF6, in terms of LR formation. Our findings indicate that H3K27 methylation and demethylation activities are likely coordinated to ensure proper LR organogenesis.
Datification and the Pursuit of Meaningfulness in Work
Authors: Stein Mari‐Klara , Wagner Erica L. , Tierney Pamela , Newell Sue , Galliers Robert D. 
Published: September 2018

AbstractProliferation of digital means of tracking worker activities has contributed to the rise of data‐driven approaches to managing people, with employees often required to record their activities for accountability purposes. Increased requirement for such datification work occurs at a juncture where meaningfulness is one of the most sought‐after work features. Datification work could both facilitate and hinder the pursuit of meaningfulness, yet literature provides little guidance into the nature of the connection and how it transpires. Our inductive study of academic professionals using an accountability system suggests that datification work characteristics link to meaningful work experiences in complex ways. We advance current theory on work meaningfulness by theorizing the role of a new work condition – datification – in meaningfulness experiences of professionals, outlining how system design and the institutional context become important elements influencing meaningful work experiences, and explaining how meaningfulness experiences are constructed through system appropriations.
Supply Chain Power and Real Earnings Management: Stock Market Perceptions, Financial Performance Effects, and Implications for Suppliers
Authors: Lanier Danny , Wempe William F. , Swink Morgan 
Published: September 2018

This study examines supply chain power in the context of real earnings management (REM), instances in which executives execute (or forego) operations transactions for the sole purpose of meeting or beating earnings targets. We examine whether powerful major customers in supply chains exploit their positions to engage in REM to a greater degree than less powerful firms. We also examine (1) whether the stock market reacts differently to major customers’ and nonmajor customers’ REM, (2) whether any difference exists between major customers’ and nonmajor customers’ post‐REM financial performance, and (3) how suppliers are impacted by their major customers’ REM behavior. Results suggest that major customers exploit their supply chain power to engage in more REM. In contrast to the skeptical stock market reaction when other firms engage in REM, we find no evidence that major customers’ earnings are discounted when there is evidence of REM. Instead, the market appears to interpret major customers’ behavior as “legitimate” uses of power in supply chain management, rather than REM typically considered to be value‐destroying. Further, we find that in post‐REM periods, major customers that engage in REM exhibit better operating cash flow performance than nonmajor customers who do so. These findings suggest that the consequential costs of REM are lower for major customers than for nonmajor customers. Finally, we report evidence that the particular form of major customers’ REM appears to determine the impact on their suppliers. Suppliers’ financial performance deteriorates when major customers’ REM entails discretionary expense cuts. These findings offer new insights into the benefits and uses of power in supply chain relationships, in a previously unexplored context. We discuss the implications of the findings for future research.
Effect of saliva esterase activity on ester solutions and possible consequences for the in‐mouth ester release during wine intake
Authors: Pérez‐Jiménez María , Rocha‐Alcubilla Nuria , Pozo‐Bayón María Ángeles 
Published: September 2018

AbstractThe aim of this study was to investigate the role of saliva esterase activity on carboxylic esters typically associated with pleasant and fruity aromas in wine. For this, ex vivo experiments using the same fresh and inactivated (without enzymatic activity) human saliva with a mixture of carboxylic esters with different aliphatic chain length (ethyl butanoate, ethyl pentanoate, ethyl hexanoate, ethyl octanoate, ethyl decanoate, and isoamyl acetate) were prepared. Liquid–liquid extraction with dichloromethane and GC–MS analysis were applied to the saliva systems in order to determine the reduction in ester content and the formation of their corresponding metabolic products (carboxylic acids) in the saliva systems before and after incubation at 37C. In addition, to check if there was a relationship between the susceptibility of esters to saliva hydrolysis and the amount of in‐mouth ester release during wine intake, the remaining oral amount of each ester was determined by comparing the intraoral amount immediately after spitting out the wine and 4 min later. Ex vivo experiments showed ester degradation by saliva esterase enzymes mainly acted on long chain esters (ethyl octanoate and ethyl decanoate), which gave rise to the formation of their corresponding carboxylic acids. Nonetheless, in spite of their higher susceptibility to saliva enzymes, in vivo experiments showed that long chain carboxylic esters remained in the oral cavity long after swallowing. This confirmed that ester hydrophobicity is closely related to the in‐mouth temporal release of these odorants and, therefore, behind wine aroma persistence. In wines, esters represent a group of aromatic compounds of great interest since they are linked to pleasant fruity aroma nuances. Today wine consumers are demanding fresh and long persistent fruity aromatic wines. The present research contributes to better understanding the relationship between ester content in the wine and oral aroma release experienced during wine tasting, considering the changes in these compounds during oral processing. This is a necessary step when trying to unravel the factors involved in wine aroma perception and in consumer preferences, and it represents a necessary knowledge in promoting winemaking practices (e.g., the use of selected microorganisms) for improving the type and amount of these aroma compounds in the wine.
Sensory and instrumental textural changes in fillets from Pacú (Piaractus mesopotamicus) fed different diets
Authors: Pavón Yanina , Cian Raúl Esteban , Campos Soldini María Andrea , Hernández David Roque , Sánchez Sebastián , Drago Silvina Rosa 
Published: September 2018

AbstractThe influence of two dietary treatments on quality properties, like textural parameters, sensory profile, and nutritional composition of Pacú fillets (Piaractus mesopotamicus) were studied. Pacú were fed diets based on plant‐meals containing 13 g 100 g−1 fish meal (FMD) or bovine plasma protein concentrate (BPPD) as a complete replacement of fish meal. Harvested fish were filleted, kept frozen at −20C for 7 days before analysis. Chemical composition, amino acid and fatty acid profiles, and CIE‐Lab parameters of fillets were measured. Sensory characteristics and texture profile analysis (TPA) were conducted for cooked portions. Average values of TPA hardness, chewiness, and deformability modulus were higher in BPPD samples but there was no significant difference in cohesiveness between samples. In accordance with TPA, higher values of firmness and chewiness as well as less flaky muscle were detected in BPPD samples by sensory panel. However, there was no significant difference in the characteristics associated with higher freshness between samples. Total color difference was lower in BPPD samples. Differences in protein, lipid, ash, and moisture content of FMD or BPPD fillets were not found (p > .05). BPPD fillets showed higher basic and sulfur amino acids. Saturated and polyunsaturated fatty acid contents were higher in FMD fillets than BPPD. However, a significantly higher n−6/n−3 ratio for FMD fillets was observed. The higher values of textural parameters observed for BPPD cooked fillets and the lower n−6/n−3 ratio imply a better sensory and nutritional quality of fillets from fish fed with BPPD.Practical applicationsA complete study is presented on how the source of protein and lipids in feed affect both the sensory profile and the nutritional composition of fillets of Pacú (omnivorous temperate freshwater fish) cultivated in the second stage of fattening. Instrumental texture analysis of the fillets is presented, identifying the indicators that match with sensorial analysis. This analysis can help the industry of aquaculture in the evaluation of new ingredients or diets for fish feeding with impact in the quality of fillets.
Relationship between HLA‐DPA1 mRNA expression and susceptibility to hepatitis B
Authors: Ou Guojin , Liu Xiao , Yang Liu , Yu Hao , Ji Xin , Liu Fan , Xu Haixia , Qian Liqiong , Wang Jue , Liu Zhong 
Published: September 2018

AbstractChronic hepatitis B virus (HBV) infection is influenced by both viral and host factors. In genome‐wide association studies, the human leucocyte antigen HLA‐DPA1 and related polymorphism rs3077 were found to be associated with susceptibility to and spontaneous clearance of HBV infection. Here, we evaluated the association between HLA‐DPA1 mRNA expression and the risk of HBV infection. HLA‐DPA1 and rs3077 polymorphisms were investigated in 169 patients with chronic HBV and 217 healthy controls (HCs) from Sichuan Han blood donors using sequence‐based typing and meta‐analysis for HLA‐DPA1 alleles. HLA‐DPA1 mRNA levels were measured by real‐time polymerase chain reaction. The results showed that HLA‐DPA1 and rs3077 were associated with HBV infection in the Sichuan population. Rs3077T and DPA1*01:03 played protective roles in HBV infection, and rs3077C and DPA1*02:02 increased susceptibility to HBV infection. We found that the HLA‐DPA1 mRNA expression was decreased in the CHB group; in particular, the 3077CT, 3077TT, DPA1*01:03 and DPA1*02:01 alleles showed a significant decrease. Our results demonstrated, for the first time, that expression of HLA‐DPA1 alleles and rs3077 affected the risk of HBV infection. Genotypes with lower HLA‐DPA1 expression had a greater susceptibility to HBV infection. Thus, further independent studies are needed to strengthen the associations of these polymorphisms with susceptibility to and clearance of HBV infection in Chinese populations.