bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagenetic mineral development within the Upper Jurassic Haynesville‐Bossier Shale, USA
Authors: Dowey Patrick J. , Taylor Kevin G. 
Published: May 2019

AbstractDespite recent advances, diagenetic processes in fine‐grained sediments are still relatively poorly understood. Key questions still to be resolved include the types of diagenetic minerals present in mudstones and the extent of element mobility in these low permeability systems. This study utilizes data from the Haynesville‐Bossier Shale, USA, to analyze lithologies, discriminate authigenic phases and identify mobile elements during diagenesis. It has implications for understanding how authigenic minerals develop and the sources of those authigenic minerals in fine‐grained sediments. On the basis of grain‐size and mineralogy five lithologies are designated: (i) silica‐rich argillaceous mudstones; (ii) argillaceous siliceous mudstones; (iii) mixed siliceous mudstones; (iv) mixed mudstones; and (v) authigenically‐dominated mudstones. The diagenetic development of the Haynesville‐Bossier Shale can be divided into early and late diagenesis. Ferroan and non‐ferroan dolomite, framboidal pyrite and bioclast pore‐filling kaolinite and calcite grain replacements and cements all formed during early diagenesis. Late diagenetic mineral phases include illite formed by the illitization of smectite, replacive and displacive chlorite, calcite‐replacive albite, quartz‐replacive calcite and replacive and/or displacive quartz. The presence of extensive late diagenetic mineral precipitates indicates that there was a degree of element mobility on at least the local scale. Aluminium present in albite is most likely to have resulted from the illitization of smectite. Quartz overgrowths probably resulted from illitization and the pressure dissolution at quartz silt grain boundaries. Externally, hydrothermal fluids resulting from regional‐scale igneous activity appear to have played a role in the formation of chlorite and possibly albite. The work indicates that extensive mineral development and element mobility occurred during late diagenesis.
Effects of music, video, and 360‐degree video on cycle ergometer exercise at the ventilatory threshold
Authors: Bird Jonathan M. , Karageorghis Costas I. , Baker Steven J. , Brookes David A. 
Published: May 2019

Despite the seemingly ubiquitous presence of audiovisual stimuli in modern exercise facilities, there is a dearth of research examining the effects of audiovisual stimuli in combination during exercise. Accordingly, we examined the influence of a range of audiovisual stimuli on the improvement of affective, perceptual, and enjoyment responses to cycle ergometer exercise at the ventilatory threshold (VT), an intensity that is associated with the most affect‐related interindividual variability. A within‐subject design was employed, and participants (N = 18) completed a 25‐minute protocol that consisted of 2 minutes of seated rest, 5 minutes of warm‐up, 10 minutes of exercise at VT, 5 minutes of cooldown, and 3 minutes of seated rest. Participants exercised at VT under music, video, music‐video, 360‐degree video, 360‐degree video with music, and control conditions. The results revealed a condition × time interaction for perceived activation and a main effect of condition for state attention and perceived enjoyment. The 360‐degree video with music condition elicited the most positive affective valence, greatest perceived activation, most dissociative thoughts, and highest ratings of perceived enjoyment. The present findings indicate that audiovisual stimuli can influence affective, perceptual, and enjoyment responses to cycle ergometer exercise at the VT. Given the emerging support pertaining to a positive relationship between affective responses and exercise adherence, audiovisual stimuli, such as 360‐degree video with music, should be considered as a means by which to promote an enjoyable exercise experience.
Subconjunctival nodule due to Setaria equina erratic migration in a horse: First case report
Authors: Regnier Alain , Martin Coralie , Semin Marie‐Odile , Lienard Emmanuel , Geffre Anne , Douet Jean‐Yves , Raymond‐Letron Isabelle 
Published: May 2019

AbstractAn 18‐month‐old Arabian‐English filly resident in southwest France was referred for evaluation of a conjunctival mass in the right eye (OD). A pink, solid, and mobile nodular formation, measuring approximately 1.2 × 0.8 cm was found under the superior nasal bulbar conjunctiva during an ophthalmic examination that was otherwise normal. The mass was surgically removed using a standing procedure. Cytological examination of fine‐needle aspirates from the mass revealed a mixed eosinophilic‐lymphocytic inflammation. Histological examination confirmed the dense and diffuse eosinophilic‐lymphocytic infiltrate of the mass, and it revealed several cross sections of a parasitic nematode. The morphometric diagnosis identified an immature form of a filarial worm, and molecular analysis of the mitochondrial cytochrome c oxydase subunit 1 (cox1) and 12S rRNA gene sequences led to further identification of the specimen as Setaria equina. Microfilaremia was not observed on fresh blood smears. There have been no signs of local recurrence after 18 months, nor any evidence of intraocular involvement. To the authors’ knowledge, this is the first documented case of subconjunctival setariasis due to S equina in a horse.
The impact of red blood cell manufacturing variables on bacterial growth dynamics: a pilot study
Authors: Ramirez‐Arcos Sandra , Kou Yuntong , Cayer Marie‐Pierre , De Grandmont Marie‐Joëlle , Girard Mélissa , Cloutier Marc 
Published: May 2019

Background and objectivesBacterial contamination of red blood cells (RBC) remains a rare but serious clinical concern. Despite the low temperature storage of RBC, some bacteria can proliferate. The impact of RBC additive solutions (AS), manufacturing method or donor sex on bacterial growth/survival in RBC was addressed in this pilot study.Materials and methodsUsing a partial pool‐and‐split design, bacterial growth/survival was assessed in intentionally inoculated RBC, manufactured separately from male and female donors using three different manufacturing methods (two whole blood [WB] filtration methods; one RBC filtration method), and resuspended in one of four AS: SAGM, PAGGSM, AS‐1 or AS‐3. At the beginning of storage, RBC were inoculated with 10 CFU/ml of either Klebsiella pneumoniae, Staphylococcus epidermidis, Yersinia enterocolitica or Propionibacterium acnes. Manufacturing, inoculation, storage (until day 42) and monitoring of bacterial growth were conducted at two sites: Canadian Blood Services and Héma‐Québec.ResultsYersinia enterocolitica was the only bacterium that proliferated during storage at both sites. RBC tested at Canadian Blood Services had higher bacterial concentrations than those at Héma‐Québec (P = 0·0044). At Héma‐Québec, where two different manufacturing methods were used, Y. enterocolitica reached significantly higher bacterial concentrations in AS‐3 RBC (WB filtration method) compared to units prepared in the other three AS (RBC filtration method; P < 0·05). Bacterial survival/growth dependent on donor sex was not uniformly noted.ConclusionOnly one of four bacteria grew under RBC storage conditions. The results indicate that RBC manufacturing variables, rather than AS or donor sex, affect bacterial growth in RBC.
Beneficial Effects of Regular Physical Activity on Exercise-Induced Analgesia in Adolescent Males
Authors: St-Aubin Marc-Olivier , Chalaye Philippe , Counil François-Pierre , Lafrenaye Sylvie 
Published: May 2019

Purpose: To evaluate exercise-induced analgesia (EIA) effectiveness in healthy adolescent males and to investigate possible associations between EIA and physiological/psychological variables. Methods: Twenty-eight healthy adolescent males (14–17 y) participated in this study. EIA was evaluated by comparing perceptions of heat pain stimulations before and after an increasing maximal load test on a cycle ergometer (VO2max). Results: Pain intensity for mild and strong heat pain stimulations significantly decreased following physical exercise (mild: EIA = 28.6%; 95% confidence interval, 0.9–1.9; P < .001 and strong: EIA = 11.3%; 95% confidence interval, 0.3–1.4; P = .002). The number of physical activity hours per week was positively correlated with the effectiveness of EIA for mild and strong pain intensity (r = .41, P = .03 and r = .43, P = .02, respectively). Conclusions: Intense physical exercise decreases perception of intensity of experimental heat pain in healthy adolescent males. The least physically active adolescents have reduced EIA effectiveness to experimental heat pain stimulations compared with physically active ones. Adolescents adopting an active lifestyle have more endogenous pain inhibition and could, therefore, potentially be less disposed to suffer from chronic pain later in life.
Anatomy and evolution of a dynamic arroyo system, Kanab Creek, southern Utah, USA
Authors: Townsend Kirk F. , Nelson Michelle S. , Rittenour Tammy M. , Pederson Joel L. 
Published: May 2019

AbstractMany alluvial valleys in the American Southwest are entrenched within continuous arroyos, and stratigraphic evidence indicates that these fluvial systems experienced repeated periods of entrenchment and aggradation during the mid- to late-Holocene. Previous research suggests arroyo dynamics were regionally quasi-synchronous, implying that they were driven by allogenic forcing due to hydroclimatic fluctuations. However, several of these interpretations rely on records with limited age control and include distal correlations across the American Southwest. While hydroclimatic variability must exert some role, autogenic mechanisms related to catchment-specific geomorphic thresholds are hypothesized to partially control the timing of arroyo dynamics. If driven by autogenic processes, episodes of arroyo cutting and filling may not be regionally contemporaneous. Recent improvements in dating methods permit more detailed reconstructions of the timing and evolution of arroyo dynamics, allowing for a more nuanced assessment of these competing hypotheses. Here we present a uniquely large and focused chronostratigraphic data set from two alluvial reaches of Kanab Creek, located in the Grand Staircase region of southern Utah. Episodes of prehistoric arroyo cutting and filling are reconstructed from 27 sites through recognition of soils and buttressed unconformities in the arroyo-wall stratigraphy, and age control derived from 54 optically stimulated luminescence (OSL) ages and 50 radiocarbon ages.Our chronostratigraphic data set indicates five periods of channel aggradation occurred since ca. 6.0 ka, with each interrupted by an episode of arroyo entrenchment. Repeated aggradation to a similar channel elevation suggests attainment of a threshold profile, and comparison of the pre-entrenchment longitudinal profile with the modern arroyo channel demonstrates that changes between end-member entrenched and aggraded states are expressed in channel concavity and slope. We propose that arroyo dynamics are partially driven by sediment supply and the rate of channel aggradation, and that these systems must approach complete re-filling before they become sensitive to incision. Entrenchment itself appears to be associated with rapid transitions from pronounced decadal-scale aridity to pluvial (wetter) periods. Not all such hydroclimatic fluctuations are associated with arroyo entrenchment, which highlights the importance of threshold controls on the behavior of these systems. The collective period of “dynamic instability” characterized by epicycles of arroyo entrenchment and aggradation did not initiate until the mid-Holocene, when a climatic shift toward warmer and drier conditions likely increased fine-grained sediment supply to the fluvial system.
Needs and rights awareness of stroke survivors and caregivers in urban and rural China: a cross-sectional, multiple-centre questionnaire survey
Authors: Xia Xiaoshuang , Tian Xiaolin , Zhang Tianli , Wang Peilu , Du Yanfen , Wang Chunru , Wei Zhiqiang , Jiang Guojing , Cheng Qiong , Li Qiang , Li Jinpeng , Wang Qingling , Dong Qi , Guo Xiaobin , Sun Meihua , Wang Lin , Liu Ming , Li Xin 
Published: May 2019

ObjectivesStroke survivors require assistance and support in their daily lives. This survey aims to investigate the needs and rights awareness in Chinese stroke survivors and caregivers in rural and urban settings.SettingThis survey was adapted from the one created by the World Stroke Organization. The questionnaire included demands for psychological support, treatment and care, social support and information. From January 2015 to January 2016, the survey was pilot tested with urban and rural-dwelling stroke survivors and caregivers from 12 hospitals. Stroke survivors were invited to participate if they were over 18 years old and had experienced a stroke. Exclusion criteria were patients who had disorders of consciousness, significant cognitive impairment, aphasia, communication difficulties or psychiatric disorders. Only caregivers who were family members of the patients were chosen. Paid caregivers were excluded.ParticipantsOne thousand, one hundred and sixty-seven stroke survivors and 1119 caregivers were enrolled.Primary outcome measuresThe needs of stroke survivors and caregivers in rural and urban areas were compared. The correlations between needs of rural and urban stroke survivors and caregivers and potential effect factors were analysed, respectively.ResultsAmong the cohort, 93.5% reported the need for psychological support, 88.6% for treatment and care, 84.8% for information and 62.7% for social support. The total needs and each aspect of needs of stroke survivors in urban settings were greater than of those in rural settings (p<0.01). In rural areas, total needs and each aspect of needs were positively correlated with education level (p<0.01).ConclusionsNeeds and rights awareness of stroke survivors should also be recognised in both urban and rural China. According to the different needs of patients and their caregivers, regional and individualised services were needed by stroke survivors and their caregivers.
The Ghana PrenaBelt trial: a double-blind, sham-controlled, randomised clinical trial to evaluate the effect of maternal positional therapy during third-trimester sleep on birth weight
Authors: Coleman Jerry , Okere Maxfield , Seffah Joseph , Kember Allan , O’Brien Louise M , Borazjani Ali , Butler Michael , Wells Jesse , MacRitchie Sarah , Isaac Andre , Chu Kaishin , Scott Heather 
Published: May 2019

ObjectiveTo evaluate the effect, on birth weight and birth weight centile, of use of the PrenaBelt, a maternal positional therapy device, during sleep in the home setting throughout the third trimester of pregnancy.DesignA double-blind, sham-controlled, randomised clinical trial.SettingConducted from September 2015 to May 2016, at a single, tertiary-level centre in Accra, Ghana.ParticipantsTwo-hundred participants entered the study. One-hundred-eighty-one participants completed the study. Participants were women, 18 to 35 years of age, with low-risk, singleton, pregnancies in their third-trimester, with body mass index <35 kg/m2at the first antenatal appointment for the index pregnancy and without known foetal abnormalities, pregnancy complications or medical conditions complicating sleep.InterventionsParticipants were randomised by computer-generated, one-to-one, simple randomisation to receive either the PrenaBelt or sham-PrenaBelt. Participants were instructed to wear their assigned device to sleep every night for the remainder of their pregnancy (approximately 12 weeks in total) and were provided a sleep diary to track their use. Allocation concealment was by unmarked, security-tinted, sealed envelopes. Participants and the outcomes assessor were blinded to allocation.Primary and secondary outcome measuresThe primary outcomes were birth weight and birth weight centile. Secondary outcomes included adherence to using the assigned device nightly, sleeping position, pregnancy outcomes and feedback from participants and maternity personnel.ResultsOne-hundred-sixty-seven participants were included in the primary analysis. The adherence to using the assigned device nightly was 56%. The mean ±SD birth weight in the PrenaBelt group (n=83) was 3191g±483 and in the sham-PrenaBelt group (n=84) was 3081g±484 (difference 110 g, 95% CI −38 to 258, p=0.14). The median (IQR) customised birth weight centile in the PrenaBelt group was 43% (18 to 67) and in the sham-PrenaBelt group was 31% (14 to 58) (difference 7%, 95% CI −2 to 17, p=0.11).ConclusionsThe PrenaBelt did not have a statistically significant effect on birth weight or birth weight centile in comparison to the sham-PrenaBelt.Trial registration numberNCT02379728.
Challenges and opportunities for involving patients and the public in acute antimicrobial medicine development research: an interview study
Authors: Gibson Andy , Kok Michele , Evans David , Grier Sally , MacGowan Alasdair 
Published: May 2019

ObjectivesTo explore what approaches to patient and public involvement (PPI) in antimicrobial medicines development are currently being used, what the impacts of PPI are on antimicrobial medicines development and what the barriers are to its implementation.DesignInterview study.SettingAntimicrobial medicines development research.ParticipantsPrincipal investigators known to have led studies involving PPI or expressed an interest in PPI.ResultsThere is very little published work on PPI in antimicrobial research. Individual interviewees expressed scepticism about the contribution that PPI could make to different stages of the medicines development life cycle but collectively identified a range of potential benefits of PPI covering most stages of the medicines development process.ConclusionsA major issue in developing PPI in antimicrobial medicines development research will be in overcoming the view that, at best, PPI has only a marginal contribution to make in this area of research. The findings from this study, although mixed, suggest that well-designed PPI has an untapped potential to enhance antimicrobial research.
Role of personality disorder in randomised controlled trials of pharmacological interventions for adults with mood disorders: a protocol for a systematic review and meta-analysis
Authors: Kavanagh Bianca E , Brennan-Olsen Sharon Lee , Turner Alyna , Dean Olivia M , Berk Michael , Ashton Melanie M , Koivumaa-Honkanen Heli , Williams Lana J 
Published: May 2019

IntroductionRemission rates for mood disorders, including depressive and bipolar disorders, remain relatively low despite available treatments, and many patients fail to respond adequately to these interventions. Evidence suggests that personality disorder may play a role in poor outcomes. Although personality disorders are common in patients with mood disorders, it remains unknown whether personality disorder affects treatment outcomes in mood disorders. We aim to review currently available evidence regarding the role of personality disorder on pharmacological interventions in randomised controlled trials for adults with mood disorders.Methods and analysisA systematic search of Cochrane Central Register of Controlled Clinical Trials (CENTRAL) via cochranelibrary.com, PubMed via PubMed, EMBASE via embase.com, PsycINFO via Ebsco and CINAHL Complete via Ebsco databases will be conducted to identify randomised controlled trials that have investigated pharmacological interventions in participants aged 18 years or older for mood disorders (ie, depressive disorders and bipolar spectrum disorders) and have also included assessment of personality disorder. One reviewer will screen studies against the predetermined eligibility criteria, and a second reviewer will confirm eligible studies. Data will be extracted by two independent reviewers. Methodological quality and risk of bias will be assessed using the Cochrane Risk of Bias tool. A systematic review, and if sufficient evidence is identified, a meta-analysis will be completed. Meta-analysis will be conducted using the standardised mean difference approach and reported with 95% CIs. A random effects model will be employed and statistical heterogeneity will be evaluated using the I2statistic. Prespecified subgroup analyses will be completed.Ethics and disseminationAs this systematic review will use published data, ethics permission will not be required. The outcomes of this systematic review will be published in a relevant scientific journal and presented at a research conference.Trial registration numberCRD42018089279.
Chinese herbal medicine for diabetic kidney disease: a systematic review and meta-analysis of randomised placebo-controlled trials
Authors: Zhang La , Yang Lihong , Shergis Johannah , Zhang Lei , Zhang Anthony Lin , Guo Xinfeng , Qin Xindong , Johnson David , Liu Xusheng , Lu Chuanjian , Xue Charlie Changli , Mao Wei 
Published: May 2019

ObjectivesTo provide a broad evaluation of the efficacy and safety of oral Chinese herbal medicine (CHM) as an adjunctive treatment for diabetic kidney disease (DKD), including mortality, progression to end-stage kidney disease (ESKD), albuminuria, proteinuria and kidney function.DesignA systematic review and meta-analysis.MethodsRandomised controlled trials (RCTs) comparing oral CHM with placebo as an additional intervention to conventional treatments were retrieved from five English (Cochrane Central Register of Controlled Trials, MEDLINE, Embase, Allied and Complementary Medicine Database and Cumulative Index of Nursing and Allied Health Literature) and four Chinese databases (China BioMedical Literature, China National Knowledge Infrastructure, Chonqing VIP and Wanfang) from inception to May 2018. RCTs recruiting adult DKD patients induced by primary diabetes were considered eligible, regardless of the form and ingredients of oral CHM. Mean difference (MD) or standardised mean difference (SMD) was used to analyse continuous variables and RR for dichotomous data.ResultsFrom 7255 reports retrieved, 20 eligible studies involving 2719 DKD patients were included. CHM was associated with greater reduction of albuminuria than placebo, regardless of whether renin–angiotensin system (RAS) inhibitors were concurrently administered (SMD −0.56, 95% CI [−1.04 to –0.08], I2=64%, p=0.002) or not (SMD −0.92, 95% CI [−1.35 to –0.51], I2=87%, p<0.0001). When CHM was used as an adjunct to RAS inhibitors, estimated glomerular filtration rate was higher in the CHM than placebo group (MD 6.28 mL/min; 95% CI [2.42 to 10.14], I2=0%, p=0.001). The effects of CHM on progression to ESKD and mortality were uncertain due to low event rates. The reported adverse events in CHM group included digestive disorders, elevated liver enzyme level, infection, anaemia, hypertension and subarachnoid haemorrhage, but the report rates were low and similar to control groups. The favourable results of CHM should be balanced with the limitations of the included studies such as high heterogeneity, short follow-up periods, small numbers of clinical events and older patients with less advanced disease.ConclusionsBased on moderate to low quality evidence, CHM may have beneficial effects on renal function and albuminuria beyond that afforded by conventional treatment in adults with DKD. Further well-conducted, adequately powered trials with representative DKD populations are warranted to confirm the long-term effect of CHM, particularly on clinically relevant outcomes.PROSPERO registration numberCRD42015029293.