bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatio-Temporal Expression and Functional Analysis of miR-206 in Developing Orofacial Tissue
Authors: Mukhopadhyay Partha , Smolenkova Irina , Warner Dennis , Pisano Michele M. , Greene Robert M. 
Published: August 2018

Background:Development of the mammalian palate is dependent on precise, spatiotemporal expression of a panoply of genes. MicroRNAs (miRNAs), the largest family of noncoding RNAs, function as crucial modulators of cell and tissue differentiation, regulating expression of key downstream genes. </P><P> Observations: Our laboratory has previously identified several developmentally regulated miRNAs, including miR-206, during critical stages of palatal morphogenesis. The current study reports spatiotemporal distribution of miR-206 during development of the murine secondary palate (gestational days 12.5-14.5). </P><P> Result and Conclusion: Potential cellular functions and downstream gene targets of miR-206 were investigated using functional assays and expression profiling, respectively. Functional analyses highlighted potential roles of miR-206 in governing TGF&#223;- and Wnt signaling in mesenchymal cells of the developing secondary palate. In addition, altered expression of miR-206 within developing palatal tissue of TGF&#223;3-/- fetuses reinforced the premise that crosstalk between this miRNA and TGF&#223;3 is crucial for secondary palate development.
The Use of the COBIT Framework to Reveal the Reality of Mobile Information Technology Management and its Role in Information Quality Governance
Authors: Ismail Hadi Kh. 
Published: August 2018

The aim of the study is to use the COBIT framework to reveal the reality of the Mobile Information Technology management , and its role in achieving information quality governance in the Directorate of Traffic in Dohuk Governorate. The fifth version of the COBIT framework identifies four domains of mobile IT management: 1- (Align , Plan and Organize) ,2- (Build, Acquire and Implement) , 3- (Deliver, service ,and support) ,and 4- (Monitor ,Evaluate ,and Assess) , and Three criteria for information quality governance (Intrinsic quality, Contextual quality, and Security quality). In order to reach the results of the study, We have relied on the available in the literature of the subject in order to build the conceptual and methodological frameworks. A questionnaire was used for collection of field data and was distributed to (51) managers in the Directorate. The sample included managers, heads of departments, and mobile team leaders who directly deal with mobile information technology . Statistical analysis of the data was conducted using statistical software (SPSS). A number of statistical indicators that formed the basis for presenting and discussing the results of field analysis. The most important conclusions of the study were the existence of statistically significant positive correlation between the Mobile Information Technology management and the information quality governance according to the COBIT framework, and mobile information technology management as an independent variable has a significant impact on information quality governance as a dependent variable The research presented a number of suggestions , including increasing the investment in mobile information technology infrastructure by the Directorate of Traffic in Duhok governorate, keeping abreast of the rapid developments in it, and benefiting from the COBIT framework in Mobile Information Technology management and information quality governance.
INDUCTION OF CASPASE-3 DEPENDENT APOPTOSIS, CELL CYCLE ARREST AND CYTOTOXICITY IN BREAST CANCER CELLS BY ABRUS PRECATORIUS
Authors: Sofi Mohammed Shafi , Nabi Shabnum 
Published: August 2018

Objective: To evaluate the leaf extract of Abrus precatorius as a potential therapy for breast cancer treatment.Methods: Aqueous leaf extracts of A. precatorius was prepared by the process of maceration. The collected filtrate was further partitioned successively into five solvent fractions starting from water, hexane, chloroform, ethyl acetate and butanol by solvent fractionation method using separating funnel. Finally, all the five fractions were subjected to cytotoxic activity assay. The molecular mechanism underlying cytotoxicity was determined by using various approaches viz., 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, Fluorescence-activated cell sorting (FACS) analysis, Western blot analysis, casp-glow assay and Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) analysis.Results: Among five fractions only ethyl acetate fraction of A. precatorius (EAF-AP) showed significant cytotoxic activity on MDA-MB-231 cells, with an IC50 value of 47.3 µg/ml. Apoptosis was confirmed by the appearance of Sub G0/G1 (apoptotic) peak by FACS analysis. Western blotting results clearly indicated cleavage of Caspase-3 and PARP. Casp-glow assay confirmed activation of caspase-3, an important mediator of apoptosis. Semi-quantitative RT-PCR analysis showed an up-regulation of pro-apoptotic genes (p21, p53 and Bax) and down-regulation of the anti-apoptotic Bcl-2 gene, which is an important hallmark of an apoptosis.Conclusion: All these results indicate that EAF-AP, induced apoptosis in MDA-MB-231 cells, making A. precatorius a potentially good candidate for anticancer drug development.
PENGARUH EFEKTIFITAS KOMITE AUDIT TERHADAP FINANCIAL DISTRESS
Authors: Rahmawati Evi , Herlambang Prasetya 
Published: August 2018

This study examines the effect of the size of the audit committee, the independence of the audit committee, frequency of meetings; financial literacy; liquidity; leverage and profitability towards company’s financial distress. This study uses manufacturing companies listed on the Indonesia Stock Exchange (IDX), Malaysia Stock Exchange (KLSE) and Singapore Stock Exchange (SGX) period 2014-2015. The number of manufacturing companies that is used in this study comprises of 124 Indonesian companies; 138 Malaysian companies and 98 Singapore companies. This study also analyzes the effect of company’s financial distress towards the possibility of fraud. The results of this study shows that there is a significant positive effect of leverage towards financial distress in Indonesia and in Singapore. There are differences in factors affecting financial distress in Indonesia and Malaysia. There are differences in factors affecting financial distress in Indonesia with Singapore. As for the size of the audit committee, the independence of audit committees, frequency of meetings, financial knowledge, liquidity, and profitability do not affect significantly towards company’s financial distress.
A existência humana como resposta: a antropologia cristã à luz da compreensão bíblica do ser humano
Authors: Brustolin Leomar Antônio , Bedin Fontana Leandro Luis 
Published: August 2018

O presente artigo indaga pelo sentido antropológico do ser humano no contexto bíblico da criação e da existência humana. A hipótese é que a recuperação de algumas afirmações-chave acerca do ser humano presentes na Sagrada Escritura poderia lançar luz sobre algumas ambiguidades e dualismos existentes em muitas abordagens antropológicas contemporâneas. Uma análise detalhada do conceito hebraico de nefeš revisará a noção ocidental de alma bem como sua sobrevalorização em detrimento da corporeidade. De outro lado, a descoberta da vocação fundamental e pessoal do ser humano à vida e de sua relação estrutural com Deus e seus semelhantes põe em xeque uma atitude imanentista reducionista, que nada vê além dos limites da subjetividade moderna. O estudo demonstra que a diferença radical do pensamento bíblico-semita em relação ao nosso tempo possui, de fato, um potencial crítico benéfi co a qualquer antropologia cristã e mesmo secular.
De mãe de Jesus à Senhora do Céu: a evolução da devoção à Virgem Maria na igreja cristã medieval
Authors: Portella Rodrigo 
Published: August 2018

A Igreja Católica celebrou, em 2017, no Brasil e em Portugal, o chamado Ano Mariano, em referência aos 300 anos de descoberta da imagem de Aparecida e dos 100 anos das manifestações marianas em Fátima. Embora sejam bastante presentes entre nós – particularmente aos católicos – aspectos dessas duas devoções modernas, ainda são incipientes, no Brasil, análises sobre a devoção mariana no período medieval. No âmbito do Ano Mariano, o presente artigo pretende oferecer uma visão histórica sobre o desenvolvimento da devoção e iconologia mariana durante a Idade Média. Portanto o artigo analisa as representações e imaginários de Maria a partir de contextos sociais e eclesiásticos de cada época do período medieval, destacando como Maria passa de figura imperial e ligada ao poder civil e eclesiástico a formas figurativas e devocionais mais ligadas, especificamente, à vida e às preocupações diárias do povo.
Mito e acontecimento: as relações entre mitologia e história nas teorias de Eliade e Girard
Authors: Dorneles Vanderlei 
Published: August 2018

Este artigo parte do pressuposto da retomada dos mitos como textos da cultura a partir da segunda metade do século 20 para analisar as teorias dos fi lósofos Eliade e Girard em relação à ideia de acontecimento e tempo histórico conforme implicados nas narrativas míticas. O objetivo é compreender o conceito de acontecimento histórico que os autores têm em mente ao tratar com os eventos por trás dos textos mitológicos. O estudo é feito a partir de uma análise comparativa entre as ideias mais centrais dos autores em relação a mito e história. A análise permite propor um paralelo mínimo entre o “tempo primordial” de Eliade, como o momento original dos eventos míticos, e os “fatos históricos” de perseguição fundantes dos mitos segundo a visão de Girard.
A pesquisa e a epistemologia em Ensino Religioso evidenciadas em eventos e no grupo de pesquisa da Faculdades EST
Authors: Brandenburg Laude Erandi 
Published: August 2018

O artigo se propõe a apresentar a trajetória de pesquisa na área do Ensino Religioso na Faculdades EST e a analisar os eventos de Ensino Religioso realizados nesse âmbito no que tange a conceitos e a conteúdos de pesquisa. Nessa perspectiva, analisa conceitos, características e contextualização da pesquisa em termos gerais no Brasil e especificidades concernentes ao Ensino Religioso no âmbito dessa instituição de ensino superior (IES). Contextualiza a pesquisa na escola e na academia e propõe uma interlocução entre esses dois loci de pesquisa. A metodologia está baseada no levantamento de temas dos eventos realizados e das temáticas das produções resultantes diante do desafi o lançado pelos temas dos simpósios elencados. Retrata também a relação que essas produções têm com o processo de formação docente como uma culminância das responsabilidades das IES com o ensino, a pesquisa e a extensão.
Motivating Learning in Mathematics Through Collaborative Problem Solving: A Focus on Using Rich Tasks
Authors: Hussain Nasreen , Mirza Anusha 
Published: August 2018

This paper is based on the concept that lively and interactive math classes are possible by incorporating rich tasks to meet the needs of students operating at different levels in the classrooms. A study was carried out to find out the impact on learning and motivation of using rich tasks at secondary level in the maths class by incorporating co-operative learning. Qualitative research paradigm was opted for the study using an action research approach and the data were collected through two semi-structured interviews conducted at the onset of the research and after the intervention. Few important findings indicate that rich tasks demand different levels of challenge and extend opportunities to those students who need them.
JEJAK KEDATANGAN UTUSAN MAJAPAHIT DI PULAU AMBON
Authors: Mujabuddawat Muhammad Al 
Published: August 2018

Kakawin Nāgarakŗtāgama describes Majapahit's territory during its victorious day almost covering the current area of the Nusantara, including the Ambon Island in the region of the Maluku Islands. However, there are only small trace of physical evidence and literary data that can prove the existence of Majapahit influence in Ambon Island, or in other words, there is no absolute proof that can be accepted by academician. The people of Ambon Island who are illiterate have an oral tradition of telling the history. Ema village in Ambon Island has an oral tradition that tells the arrival of Majapahit. This study used oral tradition analysis method also by field observation to find related artefactual data and supported by relevant literature review. Based on the results of oral tradition studies, it is known that the arrival of the delegates of Majapahit Kingdom in Ema Village is a real historical event occurred and supported by evidence of artefactual data found in the field. The results of this study became the first primary reference of historical events that occurred in the Ambon island after so long that the published literature earlier did not contain clear evidence of the interaction or the coming of the Majapahit Kingdom in Ambon Island. The result of this study is also sufficient to prove that Ambon Island is not the territory of Majapahit Kingdom.
Preferensi Struktur Organisasi Bagi Generasi Millenial
Authors: Setiawan Satria Aji , Puspitasari Nova 
Published: August 2018

Millennial or Y generation is a generation born between 1981 and 2003. They are the generation that likes flexibility, freedom as well as personal things. Their work attitude is different from previous generations, one of which is that millenial generation has a strong preference related to the organizational structure and the systems that support it. This study was conducted to analyze millennial generation preferences related to the organizational design continuum, whether millennials are more likely to mechanistic designs or more to organic organizational design. In addition, this study aims to provide strategic recommendations for designing organizational structures that can accommodate millennial needs. This research used mixed research methods by combining quantitative methods through descriptive statistical analysis and qualitative methods. Based on the research, it is known that millennials prefer to work in organizations that have organic structures with few characteristics of mechanistic organization. The ideal organization for millenial generation is an organization that has low complexity, low centralization, high formalization, low stratification, high adaptability, low production, high efficiency, and high job satisfaction.
Keywords: Millenials, Organization Structure, Mechanistic, Organic
AbstrakGenerasi millenial atau generasi Y adalah generasi yang lahir diantara tahun 1981 sampai dengan 2003. Mereka adalah generasi yang cenderung lebih fleksibel dan menyukai kebebasan serta hal yang sifatnya personal. Sikap kerja mereka pun berbeda dengan generasi-generasi sebelumnya, salah satunya adalah generasi millenial memiliki preferensi yang kuat terkait dengan struktur organisasi dan sistem yang mendukungnya. Penelitian ini dilakukan untuk menganalisis mengenai preferensi generasi millenial terkait dengan kontinum desain organisasi, apakah generasi millenial lebih cenderung kepada desain mekanistik atau lebih condong kepada desain organisasi organik. Selain itu, penelitian ini bertujuan untuk memberikan rekomendasi strategis untuk menyusun desain struktur organisasi yang mampu mengakomodasi kebutuhan generasi millennial. Penelitian ini menggunakan metode penelitian campuran dengan menggabungkan metode kuantitatif melalui analisis statistika deskriptif dan metode kualitatif. Berdasarkan penelitian, diketahui bahwa generasi millenial lebih memilih untuk bekerja di organisasi yang memiliki struktur organik dengan sedikit karakteristik organisasi mekanistik. Organisasi yang ideal bagi generasi millenial adalah organisasi yang memiliki kompleksitas rendah, sentralisasi rendah, formalisasi tinggi, stratifikasi rendah, kemampuan adaptasi tinggi, produksi rendah, efisiensi tinggi, dan kepuasan kerja tinggi.
Kata kunci: Generasi Millenial, Struktur Organisasi, Mekanistik, Organik
Occurrence of the sexual morph of Erysiphe macleayae on Chelidonium majus in Romania
Authors: Chinan Vasilică-Claudiu 
Published: August 2018

Abstract
The sexual morph (chasmothecium) of Erysiphe macleayae on Chelidonium majus has been found in Romania for the first time. Although the asexual morph of this powdery mildew on C. majus is known from many countries, the occurrence of chasmothecia on this host is rather rare. A description of morphological characters and an analysis of the phylogenetic relationship of ITS sequences of the Romanian specimens are presented.
Subalpine vegetation in Giresun Mountains (Turkey)
Authors: Hüseyinova Rena , Yalçin Erkan 
Published: August 2018

AbstractIn this study, the subalpine vegetation in the Giresun Mountains of northern Turkey was investigated. The study area included north- and south-facing slopes at altitudes ranging betweenc.2000 and 2500 meters. For vegetation classification and for describing the relationships between vegetation and environment, traditional Braun-Blanquet methods and multivariate analysis techniques were used. The vegetation mainly consisted of subalpine grasslands and coniferous cushion scrubs.Caricetea curvulaeandAstragalo microcephali-Brometea tomentelliwere found to be dominant syntaxa in the vegetation of the study area. Land topography, soil physical and chemical factors and species richness have important impacts on the development of subalpine vegetation according to the results of multivariate analysis. Three associations and two subassociations were newly determined and classified. Hemicryptophytes, chamaephytes and geophytes participated in the floristic composition of these syntaxa. EUNIS habitat code and names for described syntaxa were also proposed.
Retrospective study of 37 Cavalier King Charles Spaniel dogs diagnosed with Chiari-like malformation and Syringomyelia
Authors: Cucoș Cătălina Anca , Constantinescu Radu , Barut Ateș , Ionașcu Iuliana , Vlăgioiu Constantin 
Published: August 2018

Abstract
Chiari-like malformation represents a congenital anomaly that affects the bony cranial base and the hindbrain, leading to fluid filled cavities formation in the spinal cord, condition named Syringomyelia. This paper aims to assess the variety of the clinical signs and to evaluate the magnetic resonance imaging findings in thirty- seven Cavalier King Charles Spaniel dogs. The study was performed over a four-year period, from 2013 to 2017, all cases underwent neurological examination, full diagnostic work-up, including magnetic resonance imaging scans of the brain, cervical and upper thoracic spinal cord. Thirty-seven dogs were included in this study, 23 females and 14 males, with a mean age of 3.6±2.1years. The commonest clinical findings encountered were neuropathic pain and vocalization, seen in all 37 cases, followed by scratching, facial rubbing, paw licking, air licking, tail chasing, seizures and unilateral facial paralysis. Different grades of cerebellar herniation and cervical syrinxes were noted in all cases, other magnetic resonance imaging findings encountered were medullary kinking, presyrinx and ventriculomegaly. In establishing the diagnosis of the Chiari-like malformation and Syringomyelia, the breed, clinical history and the symptomatology are very important, but only magnetic resonance imaging technique can provide quantitative assessment of the nervous system lesions.
Motion artifact detection in colonoscopy images
Authors: Kaçmaz Rukiye Nur , Yılmaz Bülent , Dündar Mehmet Sait , Doğan Serkan 
Published: August 2018

Abstract
Computer-aided detection is an integral part of medical image evaluation process because examination of each image takes a long time and generally experts’ do not have enough time for the elimination of images with motion artifact (blurred images). Computer-aided detection is required for both increasing accuracy rate and saving experts’ time. Large intestine does not have straight structure thus camera of the colonoscopy should be moved continuously to examine inside of the large intestine and this movement causes motion artifact on colonoscopy images. In this study, images were selected from open-source colonoscopy videos and obtained at Kayseri Training and Research Hospital. Totally 100 images were analyzed half of which were clear. Firstly, a modified version of histogram equalization was applied in the pre-processing step to all images in our dataset, and then, used Laplacian, wavelet transform (WT), and discrete cosine transform-based (DCT) approaches to extract features for the discrimination of images with no artifact (clear) and images with motion artifact. The Laplacian-based feature extraction method was used for the first time in the literature on colonoscopy images. The comparison between Laplacian-based features and previously used methods such as WT and DCT has been performed. In the classification phase of our study, support vector machines (SVM), linear discriminant analysis (LDA), and k nearest neighbors (k-NN) were used as the classifiers. The results showed that Laplacian-based features were more successful in the detection of images with motion artifact when compared to popular methods used in the literature. As a result, a combination of features extracted using already existing approaches (WT and DCT) and the Laplacian-based methods reached 85% accuracy levels with SVM classification approach
An efficient radio frequency channel distribution in 5g heterogeneous cellular networks for avoiding cross-tier interference in macro and small cells
Authors: Qaddus Ahmed , Hassan Shahzad , Minhas Abid Ali 
Published: August 2018

Abstract
Recently, the need for user data rate traffic has increased for running high-bandwidth applications. Therefore, the way forward lies in 5G heterogeneous cellular networks. The 5G network is comprised of two network hierarchies. As the first hierarchy, there are MBSs with large macro cells for macro users. As the second hierarchy, there are FBSs referred to as small cells for femto users. The 5G networks encourage the use of large macro and small cells for efficient utilisation and distribution of channel resources. In this study, the authors have proposed an efficient RF channel distribution mechanism on the basis of the current SINR levels of FUEs and MUEs. On the basis of the users’ present SINR levels, the channels will be allocated by the central MBS to MUEs and FUEs via FBSs. The major obstacle in RF channel allocation to FUEs and MUEs is cross-tier interference at the downlink channel at the MUEs and FUEs from the transmitted signals of MBSs and FBSs. In this study, an efficient RF channel allocation scheme is proposed on the basis of channel modelling constraints, which will minimise the cross-tier interference at the downlink channel at the MUEs and FUEs during RF channel allocation to FUEs and MUEs present in the same coverage area