bluuebunny/crossref_metadata_2025_split huggingface dataset:
A robust method to identify meteor showers new parent bodies from the SonotaCo and EDMOND meteoroid orbit databases
Authors: Guennoun M. , Vaubaillon J. , Čapek D. , Koten P. , Benkhaldoun Z. 
Published: January 2019

Context. Several new meteor showers are added to the International Astronomical Union (IAU) list of meteor showers every year. Given the multiplication of video meteor measurements new parent bodies are to be found in addition to new showers. Such an endeavor is usually performed by comparing orbital elements, using a high threshold single-linking Dsh-criterion. However, questions remain about the accuracy of the method and the veracity of the newly associated parent bodies.
Aims. Our goal is to find the presence of new parent bodies in a statistical meaningful way.
Methods. A search for parent bodies was performed among SonotaCo and EDMOND databases. The association of asteroids with meteors was based on different methods, discussed and compared below. In addition, a thorough statistical test was performed in order to investigate the possible random associations.
Results. A list of potential new parent bodies associated with at least 50 meteors is found. A statistical test was used to show whether the group of meteor orbits and the asteroid is a random coincidence or not. Out of 54 potential new parent bodies, only three new parent bodies are not excluded by the statistical test: 2014 BN14, 2015 TX24 and 2015 QT3, with a probability of chance occurrence of 37, 10 and 13%, respectively. This shows the need for rigorous method when searching for the existence of meteor showers and parent bodies.
Conclusions. Ideally, such a test (or even better, tests) should be conducted in order to confirm (or not) the current IAU list of meteor showers. Similarly, all meteor orbit data in our databases should ideally be revisited using the latest methods providing a better estimate of the real uncertainty and accuracy of the derived orbits.
Arzneimittelinteraktionen, die man kennen muss!
Authors: Voigt Niels , Ort Katharina , Sossalla Samuel 
Published: January 2019

AbstractDrug-drug interactions (DDI) represent a significant problem in modern medicine. The number of patients with multi-morbidity, who take multiple drugs, is constantly increasing (polypharmacy). The related exponential increase in potential DDI is almost incomprehensible. In this article, we review pharmacodynamic DDI and provide clinically relevant examples. In addition, we extensively review pharmakokinetic DDI (e. g. through the cytochrome P450-system or p-glycoproteins) that can modify the plasma concentration of many compounds, thereby also increasing the likelihood of unwanted side effects. Finally we provide tools, which may help clinicians in their daily practice to identify and avoid potential DDI. In the context of an ageing society receiving polypharmacy, a better awareness of DDI and of strategies to prevent them is expected to reduce mortality and morbidity.
Das thorakale Aortenaneurysma – Diagnostik und Behandlungsstrategien
Authors: Fiorucci Beatrice , Banafsche Ramin , Jerkku Thomas , Pichlmaier Maximilian , Kölbel Tilo , Rantner Barbara , Tsilimparis Nikolaos 
Published: January 2019

Was ist neu?
Diagnostik Die CTA hat sich mit der kontinuierlichen Verbesserung der Qualität, Geschwindigkeit und Verfügbarkeit als optimales diagnostisches Verfahren für die thorakale Aorta etabliert. Daneben gewinnt die MRT zunehmend an Wichtigkeit, hauptsächlich wegen der exakten Darstellung von Wandveränderungen der Aorta und der Möglichkeit, durch innovative Protokolle dynamische Fluss-Phänomene abzubilden.
Behandlungsstrategien Nachdem sich die TEVAR als Therapie der Wahl für die Versorgung von thorakalen Aortenpathologien durchgesetzt hat, fokussiert sich die Entwicklung dieser Technik nun auf den total endovaskulären Ansatz durch die Rekrutierung einer suffizienten proximalen Landezone im Aortenbogen, proximal der LSA mittels gebranchter oder fenestrierter Aortenbogen-Prothesen, die supraaortale Gefäße mit einbeziehen. Da neurologische Komplikationen wie der perioperative Schlaganfall oder die spinale Ischämie derzeit die größte Herausforderung bei endovaskulären Verfahren darstellen, ist intensive Forschung und stetige Optimierung der Techniken die Grundlage für eine sichere endovaskuläre Zukunft in der Versorgung thorakaler Aortenpathologien.
Refractory Bergmann type A bile leak: the need to strike a balance
Authors: Mutignani Massimiliano , Forti Edoardo , Larghi Alberto , Dokas Stefanos , Pugliese Francesco , Cintolo Marcello , Bonato Giulia , Tringali Alberto , Dioscoridi Lorenzo 
Published: January 2019

Abstract
Background and study aims Endoscopic therapy for postoperative Bergmann type A bile leaks is based on biliary sphincterotomy ± stent insertion. However, recurrent or refractory bile leaks can occur.
Patients and methods This was retrospective study including all consecutive patients who were referred to our center with a Bergmann type A bile leak refractory to previous conventional endoscopic treatments.
Results Seventeen patients with post-cholecystectomy-refractory Bergmann type A bile leak were included. All had received prior endoscopic biliary sphincterotomy with biliary stent or nasobiliary catheter placement and all had a percutaneous or surgical abdominal drainage. Repeat endoscopic retrograde cholangiopancreatography (ERCP) confirmed a Bergmann type A bile leak and in all patients we observed that the abdominal drainage was placed adjacent to the origin of the fistula. Our treatment consisted of pulling the drain away from the fistulous site, with extension of the previous sphincterotomy when needed. The treatment was successful in all cases. Mild complications occurred in three patients.
Conclusions Our retrospective study shows that refractory Bergmann type A bile leak may be a consequence of an unfavorable position of the abdominal drainage tube, which can be corrected by pulling the drain away from the origin of the fistula. This establishes a favorable pressure gradient that leads the bile flowing from the bile duct into the duodenum.
Die laryngotracheale Resektion als Alternative zum permanenten Tracheostoma
Authors: Aleksanyan A. , Stoelben E. 
Published: January 2019

ZusammenfassungEinleitung Zervikale Tracheastenosen als Folge von Tracheotomien oder Tumoren sowie idiopathischer Genese können in der Regel durch eine Tracheaquerresektion unterhalb des Ringknorpels dauerhaft geheilt werden. Im Falle einer Beteiligung des Ringknorpels erhöhen sich die Komplexität und das Risiko des Eingriffs. Wir berichten über die Technik der laryngotrachealen Resektion und Rekonstruktion und vergleichen in unserem eigenen Patientengut die Ergebnisse der zervikalen Tracheaquerresektion und der laryngotrachealen Resektion in Bezug auf ihre perioperativen Ergebnisse.Patienten und Methode In unserer Klinik wurden im Zeitraum von 01/2005 bis 12/2015 über 800 Tracheaeingriffe durchgeführt. Davon waren 111 zervikale Trachearesektionen mit 76 Tracheaquerresektionen und 35 laryngotracheale Resektionen. Die Resektion erfolgte immer mit primärer Anastomose ohne Anlage eines intraoperativen Tracheostomas oder einer intralaryngealen Schiene. Die perioperativen Daten wurden retrospektiv aus den Patientenakten erhoben.Ergebnisse Bei der Indikationsstellung überwiegt in beiden Gruppen die Stenose oder Defektbildung nach Tracheotomie, gefolgt von idiopathischer Stenose, Tumoren und Morbus Wegener. Es traten keine Wundheilungsstörungen an der Anastomose auf. Postoperative Tracheotomien waren mit 3 bzw. 2 Eingriffen nach Tracheaquer- bzw. laryngotrachealer Resektion selten notwendig. Pulmonale Komplikationen und die N. recurrens-Parese waren mit 5/4 und 2/2 Fällen in beiden Gruppen ähnlich häufig. Kein Patient musste mit einem definitiven Tracheostoma weiterleben. Es verstarb jeweils ein Patient im postoperativen Verlauf. Somit ergab sich kein signifikanter Unterschied in der Komplikationsrate zwischen den beiden Gruppen.Schlussfolgerung Die laryngotracheale Resektion ist ein relevanter Bestandteil der zervikalen Trachearesektion. Sie kann ohne signifikant erhöhte Morbidität durchgeführt werden und erhält so die pulmonale und Stimmfunktion des Patienten auch bei komplexen Stenosen mit Beteiligung des unteren Kehlkopfes.
Nutzende und Nicht-/Nicht-mehr-Nutzende Berliner Drogenkonsumräume im Vergleich
Authors: Stöver Heino , O´Reilly Maike-Sinead , Förster Stefan , Jurković Larissa 
Published: January 2019

ZusammenfassungEine im Jahr 2005 von der Senatsverwaltung Berlin in Auftrag gegebene Evaluation der Berliner Drogenkonsumräume ergab, dass ein großer Teil der Drogengebrauchenden in Berlin die niedrigschwelligen Angebote der Drogenkonsumräume (DKR) nicht regelmäßig oder nur selten nutzte. Die Studie „Evaluation der Nutzungsprofile der Drogenkonsumraumnutzer im Land Berlin“, die 2015 vom Institut für Suchtforschung Frankfurt durchgeführt wurde, analysiert daher die Gründe für die Nutzung bzw. Nicht-/Nicht-mehr-Nutzung von DKR in Berlin. Dieser Artikel stellt die wichtigsten Ergebnisse des Berichts vor und vergleicht diese im Anschluss mit Ergebnissen aus DKR in Frankfurt und NRW. Im Zentrum steht dabei die Frage, wie sich existierende niedrigschwellige Angebote in Berlin im Sinne der Qualitätssicherung bedarfsgerecht ausbauen lassen. Die Untersuchung zeigt, dass die DKR die definierte Zielgruppe (Opioidkonsumierende außerhalb von Substitutionsbehandlungen) überwiegend erreicht. Jedoch zeigt die Studie auch existierende Problemlagen auf und weist auf Verbesserungsbedarfe hin. So werden sowohl von den Nicht-/Nicht-mehr-Nutzenden, als auch seitens der befragten Fachkräfte die knapp bemessenen Öffnungszeiten sowie das Nutzungsverbot für Substituierte thematisiert.
Supervised Short-term High-intensity Training on Plasma Irisin Concentrations in Type 2 Diabetic Patients
Authors: Dünnwald Tobias , Melmer Andreas , Gatterer Hannes , Salzmann Karin , Ebenbichler Christoph , Burtscher Martin , Schobersberger Wolfgang , Grander Wilhelm 
Published: January 2019

AbstractIrisin is a myokine involved in adipocyte transformation. Its main beneficial effects arise from increased energy expenditure. Irisin production is particularly stimulated by physical exercise. The present study investigates the changes of plasma irisin in type 2 diabetic patients performing 2 different training modalities. Fourteen type 2 diabetic patients underwent 4 week of supervised high-intensity interval training (HIT; n=8) or continuous moderate-intensity training (CMT; n=6), with equivalent total amounts of work required. Plasma samples were collected in the resting state atbaseline and one day after the exercise intervention to analyse resting plasma irisin, blood lipids, blood glucose, hsCRP, Adiponectin, Leptin and TNF-α concentrations. In addition, body composition and VO2peak were determined Resting plasma irisin increased after HIT (p=0.049) and correlated significantly with plasma fasting glucose at follow-up (r=0.763; p=0.006). CMT did not significantly change the amount of plasma irisin, although follow-up values of plasma irisin correlated negatively with fat-free mass (r=−0.827, p=0.002) and with fasting plasma glucose (r = − 0.934, p=0.006). Plasma irisin was found to increase with higher training intensity, confirming the assumption that exercise intensity, in addition to the type of exercise, may play an important role in the stimulation of the irisin response.
Effects of Different Percentages of Blood Flow Restriction on Energy Expenditure
Authors: Pfeiffer Patrick , Cirilo-Sousa Maria , Santos Heleodório 
Published: January 2019

AbstractThe study aimed to analyze the effect of different levels of blood flow restriction (BFR) on energy expenditure (EE) and subjective perceptions of discomfort (SPD) during aerobic exercises. A sample group of 24 young men was required to walk on a treadmill for 14 min at 40% of their maximum speed, with 4 different percentages of BFR (0, 50, 80 and 100%) applied in the lower limbs (LL) once a week with a 7-day interval between the 4 evaluations. EE data were collected during the exercise periods; SPD data were collected after the exercises. There was a significant increase in EE at 50, 80 and 100% BFR compared to the condition without BFR, and between 50 and 100% BFR; however, there were no differences between 50 and 80% and 80 and 100% BFR. Discomfort showed a significant increase according to the increase in BFR. During the walking exercises with BFR, the EE strongly increased until 50% of BFR; after this level the additional increases slowed. It can be concluded that when performing aerobic exercises with BFR, there is no need to use BFR levels above 50% to reach satisfying level of EE with only a moderate level of discomfort to the practitioner. This study was registered in the Brazilian Registry of Clinical Trials (REBEC) under number RBR-3XHSJX.
Systematic Review and Meta-Analysis of Randomised, Other-than-Placebo Controlled, Trials of Non-Individualised Homeopathic Treatment
Authors: Mathie Robert , Fok Yvonne , Viksveen Petter , To Aaron , Davidson Jonathan 
Published: January 2019

Introduction This study focuses on randomised controlled trials (RCTs) of non-individualised homeopathic treatment (NIHT) in which the control (comparator) group was other than placebo (OTP).
Objectives To determine the comparative effectiveness of NIHT on health-related outcomes in adults and children for any given condition that has been the subject of at least one OTP-controlled trial. For each study, to assess its risk of bias and to determine whether its study attitude was predominantly ‘pragmatic’ or ‘explanatory’.
Methods Systematic review. For each eligible trial, published in the peer-reviewed literature up to the end of 2016, we assessed its risk of bias (internal validity) using the seven-domain Cochrane tool, and its relative pragmatic or explanatory attitude (external validity) using the 10-domain PRECIS tool. We grouped RCTs by whether these examined IHT as alternative treatment (study design 1a), adjunctively with another intervention (design 1b), or compared with no intervention (design 2). RCTs were sub-categorised as superiority trials or equivalence/non-inferiority trials. For each RCT, we designated a single ‘main outcome measure’ to use in meta-analysis: ‘effect size’ was reported as odds ratio (OR; values > 1 favouring homeopathy) or standardised mean difference (SMD; values < 0 favouring homeopathy).
Results Seventeen RCTs, representing 15 different medical conditions, were eligible for study. Three of the trials were more pragmatic than explanatory, two were more explanatory than pragmatic, and 12 were equally pragmatic and explanatory. Fourteen trials were rated ‘high risk of bias’ overall; the other three trials were rated ‘uncertain risk of bias’ overall. Ten trials had data that were extractable for analysis. Significant heterogeneity undermined the planned meta-analyses or their meaningful interpretation. For the three equivalence or non-inferiority trials with extractable data, the small, non-significant, pooled effect size (SMD = 0.08; p = 0.46) was consistent with a conclusion that NIHT did not differ from treatment by a comparator (Ginkgo biloba or betahistine) for vertigo or (cromolyn sodium) for seasonal allergic rhinitis.
Conclusions The current data preclude a decisive conclusion about the comparative effectiveness of NIHT. Generalisability of findings is restricted by the limited external validity identified overall. The highest intrinsic quality was observed in the equivalence and non-inferiority trials of NIHT.
Role of Elbow Incongruity in Canine Elbow Dysplasia: Advances in Diagnostics and Biomechanics
Authors: Ginja Mário , Colaço Bruno , Alves-Pimenta Sofia 
Published: January 2019

Elbow incongruity plays an important role in the development of elbow dysplasia and its diagnosis can be challenging. The objectives of this systematic review were to discuss elbow biomechanics and recent advances in the assessment of incongruity, to revise the diagnostic protocols suggested, debate advantages and disadvantages of measurements proposed to characterize the joint and improve screening.In spite of advances in the understanding of elbow incongruity, the exact mechanisms involved are not fully elucidated. The elbow is a complex joint and structures in contact differ in different phases of the gait cycle. Advances in the biomechanical field allowed new discoveries and a physiological type of incongruity was described. The next challenge is to unravel the dynamic incongruity. Radiology and computed tomography (CT) are nowadays the imaging tools more applied in clinical practice to quantify incongruity. But a CT standardized screening protocol is required. Most reported findings of incongruity were increased articular joint spaces. The proximity of joint structures and standardization of elbow positioning are identified as the main obstacles to a good interpretation. This review serves to highlight controversy between physiological types of cartilage covering described and pathological changes reported in arthroscopic studies. Radioulnar incongruity was reported more often than humeroulnar incongruity, yet prevalence studies are lacking. Sensitive and reproducible methodologies are in development, which seem primordial to assess the phenotypic heterogeneity.
Mindfulness Training among Parents with Preterm Neonates in the Neonatal Intensive Care Unit: A Pilot Study
Authors: Marshall Alyssa , Guillén Úrsula , Mackley Amy , Sturtz Wendy 
Published: January 2019

Objective To evaluate the feasibility of a mindfulness-based training session (MBTS) for parents of neonates born at ≤32 weeks' gestation in a level 3 neonatal intensive care unit (NICU).
Study Design Within 14 days of admission, parents completed the Parental Stressor Scale: Neonatal Intensive Care Unit Questionnaire (PSS:NICU), Cognitive and Affective Mindfulness Scale (CAMS-R), and a survey on stress management techniques. Parents then participated in a MBTS with instruction in mindfulness-based practices and were asked to practice the techniques during the NICU stay. At discharge, parents repeated the surveys to evaluate their mindfulness-based practice experience.
Results Of the 98 parents approached, 51 consented to participate (52%). Of these, 28 completed MBTS, initial, and discharge surveys. One parent had previously practiced mindfulness. The majority of parents (79%) reported that mindfulness practice was helpful, and 71% stated that they would continue their practice after NICU discharge. There was no difference in PSS:NICU or CAMS-R at discharge.
Conclusion An MBTS was feasible to provide to parents in our NICU. Parents practiced the mindfulness-based techniques and reported benefit from their mindfulness-based practice. Future studies are needed to evaluate if an MBTS is a valuable resource for NICU parents' coping.
Neglecting nonlocality leads to unrealistic numerical scheme for fractional differential equation: Fake and manipulated results
Authors: Khan Muhammad Altaf 
Published: January 2019

The purpose of this paper is to highlight the main comment raised on the published manuscript [A. Atangana and K. M. Owolabi, Math. Model. Nat. Phenom. 13, 3 (2018)] by Garrappa [Commun. Nonlinear Sci. Numer. Simul. 70, 302–306 (2019)]. It was shown that the scheme proposed by Garrappa [Commun. Nonlinear Sci. Numer. Simul. 70, 302–306 (2019)] did not capture the memory and nonlocality and led to unreliable results. Therefore, we decided to highlight and validate this issue by means of a scheme where misprinting or typos were observed. Further, we propose some examples where some of them were reported by Garrappa [Commun. Nonlinear Sci. Numer. Simul. 70, 302–306 (2019)]. It is shown further by considering different examples of the nature of linear and nonlinear problems, and we show that the scheme presented by Atangana and Owolabi [Math. Model. Nat. Phenom. 13, 3 (2018)] is correct and gives 100% agreement for the case of linear problems with the other methods in the literature, while for the case of nonlinear problems, it gives a reasonable agreement and thus the claim by Garrappa [Commun. Nonlinear Sci. Numer. Simul. 70, 302–306 (2019)] is baseless.
At the request of the Editor and Publisher of Chaos, this article has been retracted effective 14 May 2019.
Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies
Authors: Voutouri Chrysovalantis , Kirkpatrick Nathaniel D. , Chung Euiheon , Mpekris Fotios , Baish James W. , Munn Lance L. , Fukumura Dai , Stylianopoulos Triantafyllos , Jain Rakesh K. 
Published: January 2019

Significance
Vessel cooption is a strategy that many tumors employ to progress without creating new blood vessels but by exploiting preexisting vessels of the host tissue. In addition to promoting tumor growth, cooption is also associated with tumor resistance to antiangiogenic therapy. Despite the importance of this mode of tumor progression, the molecular and cellular mechanisms are not fully understood. Here, we combine intravital microscopy imaging and mathematical modeling to explore the dynamics of individual cancer cell cooption and collective response of the coopted cancer cells during antiangiogenic treatment. We also provide guidelines for effective therapeutic strategies that combine inhibition of both angiogenesis and cooption.
LncRNA FENDRR promotes high-glucose-induced proliferation and angiogenesis of human retinal endothelial cells
Authors: Shi Yu , Chen Chunsheng , Xu Yidan , Liu Yi , Zhang Hui , Liu Yang 
Published: January 2019

ABSTRACT
The study aimed to investigate the role of lncRNA FENDRR in proliferation and angiogenesis of human retinal endothelial cells (HRECs). HRECs were cultured in high-glucose medium to mimic diabetic retinopathy (DR) model. We overexpressed or knocked down FENDRR in HRECs to evaluate the effect of FENDRR expression on cell proliferation, migration, and capillary morphogenesis of HRECs under either normal glucose or high glucose condition. Results showed that VEGF and FENDRR expression were increased in blood from DR patients compared with the control subjects. Furthermore, high glucose treatment upregulated expression of VEGF and FENDRR secreted from HRECs, in a dose- and time-dependent manner. Importantly, FENDRR overexpression significantly promoted the high-glucose-induced proliferation, migration, capillary morphogenesis, and VEGF expression in HRECs. In contrast, FENDRR knockdown exerted the opposite effects. In conclusion, lncRNA FENDRR promotes the high-glucose-induced proliferation and angiogenesis of HRECs and may serve as a potential target for anti-angiogenic therapy for DR.
Report on the APMP.M.F-S2 supplementary comparison for 100 kN force
Authors: Hayashi T , Ueda K , Maejima H , Chaemthet K , Amornsakun C , Sanponpute T 
Published: January 2019

The comparison results revealed the equivalence of forces realized by the 100 kN DWM of NIMT (Thailand) to those by the 100 kN DWM of NMIJ (Japan) within their claimed uncertainties in the range up to 50 kN.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).