bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microflora of the urinary tract and intestines in patients without and with chronic endometritis
Authors: Kobaidze E. G. 
Published: February 2019

Inflammation is considered a typical response to tissue injury. At present, we see an increasing number of patients with chronic inflammation, where the damaging factor is unclear. Specifically, the pathogenetic factors of chronic endometritis (СЕ) need to be studied both in the gynecological and somatic aspects of the disease, including the functional state of other organs and systems.Aim: to analyse the microflora of the urinary tract and the intestines in patients with СЕ and various somatic conditions.Materials and methods. The intestinal and urinary tract microflora were assayed using microscopic, microbiological and molecular biological methods. To prevent false positive results and minimize sample contamination, we used our own modification.Results. The intestinal microbiota in patients with СЕ significantly differed from that in relatively healthy controls. We found a relationship between the abnormal colon microflora and the diseases of the upper and lower gastrointestinal tract, in particular, chronic cholecystitis, gastritis, and functional disorders of the intestine. These findings may become important for compbined therapy.Conclusion. The results indicate the need to individualize the pharmacol therapeutic treatment of patients with СЕ, especially those with impaired fertility. The treatment strategy should be based on minimizing the adverse drug effects, and considering the concomitant diseases.
Morbidly adherent placenta: management is real challenge
Authors: Vyas Rupa C. , Patel PrinceNrutik Amrut , Shah Sapana , Vala Shweta N. , Patel Nidhi B. 
Published: February 2019

Background: The objective of the present study was to describe management of morbidly adherent placenta with placenta previa and feto-maternal outcome.Methods: All antenatal USG diagnosed cases of morbidly adherent placenta were analyzed. The cases were managed by elective caesarean hysterectomy and non-separation of placenta at delivery. Amount of blood loss, blood transfused, ICU admission, postnatal complications and hospital stay was recorded.Results: From January 2010 to October 2018, 22 cases of morbidly adherent placenta were diagnosed on gray scale and color Doppler during antenatal ultrasound scan. Scheduled caesarean hysterectomy without attempting placental removal was done. Subtotal hysterectomy was performed in 17(77.2%) cases and total hysterectomy in remaining 5(22.8%) cases. All the patients required blood transfusion. Seven (31.8%) patients had urinary bladder injury. One case developed DIC and One needed ventilatory support. No patient died in this series.Conclusions: Antenatal diagnosed cases of morbidly adherent placenta, avoidance of placental separation and caesarean hysterectomy results in better maternal outcome.
Statistical and graphical (GGE biplot) evaluation of the adaptive ability and stability of winter barley breeding lines
Authors: Gudzenko V. N. 
Published: February 2019

Due to current global climate changes, the issue of improving adaptive capacity of crops is of high importance. It is important to create winter crop varieties with both ecological adaptability and yield stability in years with different hydrothermal conditions. In order to develop winter barley varieties with a combination of yield and stability, 14 promising breeding lines have been evaluated in the conditions of the V.M. Remeslo Myronovka Institute of Wheat of NAAS of Ukraine in 2012/2013–2014/2015 using four different sowing dates. The ANOVA revealed a reliable part in yield variation: 64.59 % for environment, 16.84 % for genotype–environment interaction, and 15.57 % for genotype. The sowing dates significantly increased the yield variation of the breeding lines. The differences between the average yields of the lines depending on sowing date within the year were 1.05 t/ha in 2012/2013, 0.90 t/ha in 2013/2014, and 1.25 t/ha in 2014/2015. For genotype–environment interaction interpretation and ranking lines by yield a number of the most known statistical parameters of adaptability, stability, and plasticity and GGE biplot were applied. The use of different sowing dates at the final stage of the winter barley breeding process is a simple but effective approach that allows a more detailed assessment of the adaptive potential of breeding lines in various growing conditions. As compared to statistical parameters, GGE biplot has some advantages for interpretation of genotype–environment interaction. This graphic model allows ranking environments to be visualized for their discriminating ability and representativeness, as well as both specifically adapted genotypes and the ones with the optimal combination of yield potential and stability to be identified in a set of environments (mega-environment). The breeding line Pallidum 4816 with the optimal combination of yield and stability, as well as the high-yielding breeding lines Pallidum 4857 and Pallidum 4659 were identified and submitted to the State Variety Testing of Ukraine as the new winter barley varieties MIP Yason, MIP Oskar and MIP Hladiator.
Damla Sulama Sistemlerinde Kullanılan Farklı Süzme Geometrisine Sahip Disk Filtre Elemanlarında Yük Kayıplarının İncelenmesi
Authors: YÜRDEM Hüseyin , YAZGI Arzu , DEMİR Vedat 
Published: February 2019

Amaç: Bu çalışmanın amacı, damla sulama sistemlerinin filtrasyon ünitelerinde yaygın olarak kullanılan disk filtrelerde yer alan farklı süzme geometrisine sahip disk filtre elemanlarının, filtredemeydana gelen yük kayıplarına etkilerinin incelenmesidir.Materyal ve Metot: Çalışmada, farklı firmalar tarafından imal edilen, farklı süzme etkinliğine sahip doğrusal yivli ve dalgalı tipte süzme yapısına sahip disk filtre elemanları kullanılmıştır. Denemelerde farklı özellikteki bu disk elemanları aynı filtre gövdesi içine ayrı ayrı yerleştirilmiş ve farklı su geçiş debilerinde yük kayıpları ölçülmüştür.Bulgular: Debi-yük kaybı ilişkileri dikkate alındığında, dalgalı tip süzme yapısına sahip disk filtre elemanlarının aynı debi koşullarında doğrusal yivli süzme yapısına sahip disk filtre elemanlarına göre daha düşük yük kaybına neden olduğu saptanmıştır.Sonuç: Çalışma sonuçları filtre elemanı seçiminin, sulama sisteminin işletme enerjisi üzerinde önemli derecede etkili olduğunu göstermektedir.
Breeding sites eradication program and Dengue fever incidence reduction in Tenggilis Public Health Center Surabaya: An Association Study
Authors: Agustin Evi 
Published: February 2019

Dengue hemorrhagic fever (DHF) is an endemic diseases in Indonesia. Incidence rates of the disease in Surabaya is reported as the highest for decades including of the area within Tenggilis Community Health Center. In the last five years, there were 273 new DHF cases notified. As the prevention for this detrimental menace, the government implemented breeding sites eradication program. This research aims to find out the association of breeding sites eradication program of covering, cleaning, burying, larvaciding, bed nets, (3M Plus) and its association with the existence of Aedes aegypti larvae index and the incidence of DHF in 2017. This research uses case control study design with The sample group was all the households in the work area of Tenggilis community health care whose family member diagnosed with. Case group diagnosis were confirmed and recorded at the Tenggilis Community Heath Care during period of April - May 2017 with total of 11 cases. The comparison group was taken using purposive sampling method within 100 meters of the observed objects’ residences. The Result of fisher exact test of knowledge level about PSN showed significant positive association with p-value: 0,009. While insignificant association was reported by variable of attitude level, action level, larvae index with p-value 1,000, 0,361. and 0,387. It can be summarized that knowledge and behavior has a significant association with the incidence of DHF in 2017 in the area of Tenggilis Community Health Center (Puskesmas). However, the existence of larva has insignificant association with the incidence of dengue in 2017 in the Tenggilis Community Health Center (Puskesmas Tenggilis) Surabaya. Community empowerment is considered as alternative approach to improve community behavior in breeding sites eradication.
The assessment of Food Handlers’ Hygiene and Environmental Sanitation in Tofu Home Industry Jombang 2018
Authors: Floridiana Zamia 
Published: February 2019

Food security is an important aspect to produce quality food that is feasible and safe for consumption by general population. Good Manufacturing Product (CPPB) is a guideline in assuring food security adhered in food production process starting from raw materials to storage system. Tofu is highlyIndonesia and it is a product with a short storability or shelf life. Among other protein sources in food, tofu had a greater consumption value of 0.157 kg/ capita/ week in 2017(Badan Pusat Statistik, 2017). The tofu producers include IRT Jombang. The purpose of this study is to analyze the hygiene of food handlers and environmental sanitation based on Peraturan Kepala BPOM RI 2012 about CPPB conducted in IRT Jombang. This research used qualitative research, observational research, and used data collection techniques such as interviews and observations. Interviews were conducted on food handlers and IRT owners while observations were made using an observation sheets. Tofu and clean water were sampled and tested in the laboratory. The results obtained were lack of food handlers hygiene and environmental sanitation. While for laboratory tests on tofu obtained negative results Salmonella sp. and Staphylococcus aureus, and exceeded the maximum limit of Coliform Total and Total Plate Numbers (ALT). Laboratory test results for chemical quality of tofu were negative in formalin and borax. It is recommended to improve monitoring and supervision system of food handlers’ hygiene and environmental sanitation in the production environment of tofu home industries
Analisis Pengaruh Gaya Kepemimpinan Transformasional, Kompensasi dan Program Pelatihan terhadap Employee Engagement Serta Dampaknya terhadap Kinerja Karyawan Di PT Angkasa Pura II (Persero)
Authors: Ferdiansyah Muhamad 
Published: February 2019

ABSTRAK

Penelitian ini bertujuan untuk menganalisis pengaruh Gaya Kepemimpinan Transformasional, Kompensasi dan Program Pelatihan terhadap Employee Engagement serta Dampakanya Terhadap Kinerja Karyawan PT Angkasa Pura II (Persero)
Populasi pada penelitian ini adalah karyawan kantor pusat PT Angkasa Pura II (Persero). Sedangkan sampel ditentukan dengan metode nonprobability sampling dengan jumlah 100 karyawan yang mengikuti program pelatihan. Metode pengumpulan data adalah dengan cara data primer dan data sekunder yang berasal dari dokumen yang sudah ada, yaitu diperoleh dari responden melalui kuesioner. Dalam melakukan analisis digunakan pooled data selama 4 tahun dari perusahaan yang dijadikan sampel. Selanjutnya data di olah dan dianalisa dengan metode SEM. Penelitian ini menggunakan variabel independent Gaya Kepemimpinan Transformasional, Kompensasi, Program Pelatihan dan variable moderasi Employee Engagement.
Berdasarkan data-data yang dikumpulkan dan diolah dengan uji analisis konfirmatori serta pengolahan penelitian dengan menggunakan Structural Equation Modelling (SEM), diperoleh hasil bahwa Gaya Kepemimpinan Transformasional berpengaruh positif dan signifikan terhadap Employee Engagement dan Kompensasi berpengaruh positif dan tidak signifikan terhadap Employee Engagement. Sedangkan Progrsm Pelatihan berpengaruh positif dan tidak signifikan terhadap Employee Engagement. Temuan dalam penelitian ini adalah penggunaan Employee Engagement sebagai variabel moderasi terbukti memberikan tingkat signifikansi probabilitas pengaruh variabel Gaya Kepemimpinan terhadap Kinerja Karyawan. dan variabel moderasi terbukti memberikan efek meningkatkan signifikansi probabilitas variabel Employee Engagement terhadap Kinerja Karyawan.

Kata kunci : Gaya Kepemimpinan Transformasional, Kompensasi, Program Pelatihan, Employee Engagement dan Kinerja Karyawan.
Design and Implementation of a Miniature Autonomous Drilling Rig for Drillbotics 2018
Authors: Arnø Mikkel , Thuve Andreas , Knoop Sebastian , Hovda Sigve , Pavlov Alexey , Florence Fred 
Published: February 2019

Abstract
The Society of Petroleum Engineers (SPE) organizes the international student competition Drillbotics. The task is to develop a miniature robotic rig to drill, in a fully autonomous operation, a vertical hole in a 35 cm rock sample with unknown layers – as fast as possible, while maintaining rig integrity and borehole quality. This paper describes the key innovations of the 2nd generation NTNU robotic drilling rig, allowing it to take first place in the 2018 competition.
The rig features a wide operational window for WOB and RPM, achieved by a custom-designed non-aggressive bit, improved BHA design, reinforced drill-string connections and improved rig framework. These improvements allow the rig to drill much faster at high WOB and RPM while avoiding drill-string twist-offs due to over-torqueing or fatigue caused by vibrations.
An autonomous high-ROP mode was employed on the competition day. The best-fit PID controller tuning enables high performance drilling through both soft- and hard formations. Built-in logics automatically detect and handle over-torqueing and stuck pipe.
A novel digitalization framework includes a fit-for-purpose data acquisition and visualization system, data-lake for unified data storage and an automatic well reporting functionality. The system logs all measurements, setpoints and calculations, including WOB, RPM, ROP, drill string torque, stand-pipe pressure, and downhole accelerations and angles (gyroscope).
The NTNU drilling rig managed to drill through a 35 cm competition rock consisting of layers of varying hardness, including a hard tile inclined at 45 deg in 3 minutes and 15 seconds, thus proving its ability of efficient and safe autonomous drilling. The drilling time of the nearest competitor was 15 minutes.
A study of industrial relative water use efficiency of Beijing: an application of data envelopment analysis
Authors: Wang Hongrui , Liu Hongli , Wang Cheng , Bai Ying , Fan Linlin 
Published: February 2019

Abstract
Evaluating and improving water use efficiency is considered one of the main ways of tackling water shortage challenges in water-scarce cities. A useful indicator for evaluating industrial water use efficiency is the relative water use efficiency (RWUE). In this paper, an industrial RWUE evaluation scheme is proposed based on data envelopment analysis (DEA) theory. In this scheme, the RWUE is divided into overall efficiency (OE), pure technical efficiency (PTE), and scale efficiency (SE). In order to help decision-makers specify the focal industry of efficiency improvement, direct water use is distinguished from indirect water use. By employing this industrial RWUE evaluation scheme, this research calculated the industrial RWUEs for 25 representative industries of Beijing (1990–2010). Results show that the OE, PTE, and SE of Beijing have improved significantly. In the primary industry, the scale adjustment fundamentally lifted OE. For the secondary industries, there still exists much room for water use efficiency improvement in technical innovation. Some emerging tertiary industries replaced traditional tertiary industries as the most efficient water users. This study serves as a valuable reference for the implementation of the Strictest Administration of Water Resources (SAWR) of China, and provides policy-makers worldwide with a useful framework of understating industrial water use efficiency.
Gender Difference Response of Male and Female Immunodeficiency Rats Treated with Tissue-specific Biomolecules
Authors: Fedulova Liliya V. , Basov Alexandr A. , Vasilevskaya Ekaterina R. , Dzhimak Stepan S. 
Published: February 2019

Background:The modern immunology is targeted to the detailed study of various immunopathological conditions at the molecular and cellular level, development of new methods for the prevention, diagnostics and treatment of contagious and non-contagious diseases of humans and animals.Methods:In the present work we took the rats with model of cyclophosphamide-induced immunodeficiency and studied the features of gender impact of the complex extract of immunocompetent organs (thymus, spleen and mesenteric lymph nodes) Sus scrofa and its separate fraction with molecular weight less than 30 kDa administered to male and female rats.Results:The impact of gender differences and tissue-specific biomolecules (30 kDa fraction) on hematological parameters (leukocytes, erythrocytes, platelets), functional activity of immune system (IL-2, IL-4, IL-6, complement system, IgG, IgM), biochemical parameters of hepatocytes functioning (activity of ALP and LDG), carbohydrate metabolism (glucose) and lipid metabolism (triglycerides).Conclusion:Decrease of ALP activity is caused by inhibition of bile formation in a liver after introduction of cytostatic agent, and in contrast to complex extract, the administration of fraction 30 kDa allows improving bile production in male rats.
Comparison of Non-radiographic Axial Spondyloarthritis and Ankylosing Spondyltis from a Single Rheumatology Hospital in Morocco
Authors: Akasbi Nessrine , Nihad Siar , Sofia Zoukal , Khadija El Kohen , Taoufik Harzy 
Published: February 2019

Background:
According to the new classification criteria developed by The Assessment
of SpondyloArthritis International Society, patients with axial spondyloarthritis (axSpA) can be
classified in 2 subgroups: Patients with radiographic axial spondyloarthritis: ankylosing spondylitis
patients (AS) and those with non-radiographic axial spondyloarthritis (nr-axSpA).

Objective:
The aim of the present study is to describe and discuss the differences and similarities
between the two subgroups.

Patients and Methods:
A cross-sectional study was conducted in a single rheumatology hospital in
Morocco. These included patients diagnosed as having axial spondyloarthritis according to ASAS
criteria 2010, during a period of 6 years. The AS and the nr-axSpA subgroups were compared for
the various axSpA-related variables.

Results:
Of the 277 patients with a diagnosis of axial SpA who were included in this study, 160 had
AS and 117 had nr-axSpA. AS and nr-ax-SpA shared a similar age at diagnosis, similar prevalence
of low back pain, lumbar stiffness, extra-articular manifestations, BASDAI and BASFI. In the multivariate
analysis, AS patients were mainly male with cervical stiffness, enthesitis, coxitis and high
level of ESR (erythrocyte sedimentation rate). The females generally had a family history of SpA
and arthritis and were associated to the nr-axSpA form in the univariate analysis.

Conclusion:
This was the first study to characterise patients with AS and nr-axSpA in Morocco.
Consistent with other studies published, this study showed that patients with nr-axSpA and patients
with AS shared a comparable degree of disease burden.
Low-Dose Radiation Advances in Coronary Computed Tomography Angiography in the Diagnosis of Coronary Artery Disease
Authors: Richards Caryl E. , Obaid Daniel R. 
Published: February 2019

Background:
Coronary computed tomography angiography (CCTA) is now widely used
in the diagnosis of coronary artery disease since it is a rapid, minimally invasive test with a diagnostic
accuracy comparable to coronary angiography. However, to meet demands for increasing
spatial and temporal resolution, higher x-ray radiation doses are required to circumvent the resulting
increase in image noise. Exposure to high doses of ionizing radiation with CT imaging is a major
health concern due to the potential risk of radiation-associated malignancy. Given its increasing
use, a number of dose saving algorithms have been implemented to CCTA to minimize radiation
exposure to “as low as reasonably achievable (ALARA)” without compromising diagnostic image
quality.

Objective:
The purpose of this review is to outline the most recent advances and current status of
dose saving techniques in CCTA.

Methods:
PubMed, Medline, EMBASE and Scholar databases were searched to identify feasibility
studies, clinical trials, and technology guidelines on the technical advances in CT scanner hardware
and reconstruction software.

Results:
Sub-millisievert (mSv) radiation doses have been reported for CCTA due to a combination
of strategies such as prospective electrocardiogram-gating, high-pitch helical acquisition, tube current
modulation, tube voltage reduction, heart rate reduction, and the most recent novel adaptive
iterative reconstruction algorithms.

Conclusion:
Advances in radiation dose reduction without loss of image quality justify the use of
CCTA as a non-invasive alternative to coronary catheterization in the diagnosis of coronary artery
disease.
Analysis of Hypoxiamir-Gene Regulatory Network Identifies Critical MiRNAs Influencing Cell-Cycle Regulation Under Hypoxic Conditions
Authors: Gupta Apoorv , Ragumani Sugadev , Sharma Yogendra Kumar , Ahmad Yasmin , Khurana Pankaj 
Published: February 2019

Background:Hypoxia is a pathophysiological condition which arises due to low oxygen concentration in conditions like cardiovascular diseases, inflammation, ascent to higher altitude, malignancies, deep sea diving, prenatal birth, etc. A number of microRNAs (miRNAs), Transcription Factors (TFs) and genes have been studied separately for their role in hypoxic adaptation and controlling cell-cycle progression and apoptosis during this stress.Objective:We hypothesize that miRNAs and TFs may act in conjunction to regulate a multitude of genes and play a crucial and combinatorial role during hypoxia-stress-responses and associated cellcycle control mechanisms.Method:We collected a comprehensive and non-redundant list of human hypoxia-responsive miRNAs (also known as hypoxiamiRs). Their experimentally validated gene-targets were retrieved from various databases and a comprehensive hypoxiamiR-gene regulatory network was built.Results:Functional characterization and pathway enrichment of genes identified phospho-proteins as enriched nodes. The phospho-proteins which were localized both in the nucleus and cytoplasm and could potentially play important role as signaling molecules were selected; and further pathway enrichment revealed that most of them were involved in NFkB signaling. Topological analysis identified several critical hypoxiamiRs and network perturbations confirmed their importance in the network. Feed Forward Loops (FFLs) were identified in the subnetwork of enriched genes, miRNAs and TFs. Statistically significant FFLs consisted of four miRNAs (hsa-miR-182-5p, hsa- miR-146b-5p, hsa-miR-96, hsa-miR-20a) and three TFs (SMAD4, FOXO1, HIF1A) both regulating two genes (NFkB1A and CDKN1A).Conclusion:Detailed BioCarta pathway analysis identified that these miRNAs and TFs together play a critical and combinatorial role in regulating cell-cycle under hypoxia, by controlling mechanisms that activate cell-cycle checkpoint protein, CDKN1A. These modules work synergistically to regulate cell-proliferation, cell-growth, cell-differentiation and apoptosis during hypoxia. A detailed mechanistic molecular model of how these co-regulatory FFLs may regulate the cell-cycle transitions during hypoxic stress conditions is also put forth. These biomolecules may play a crucial and deterministic role in deciding the fate of the cell under hypoxic-stress.