bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving paper-based discharge process; a continuous full-cycle quality improvement project in low resource setting
Authors: Abdalrahman Ihab B , Mohammed Mohammed Elsanousi Huzaifa , Abdalla Abdelmohaymin A , Abdelaziz Sulaf Ibrahim , Ali Aboaagla Abdalbagi , Osman Dina Nader Mutwakel , Ahmed Ahmed Abdelmoniem , Elwasila Hagir Emad , Mokhtar Mohammed Romaisa Hashim , Dafaalla Mohamed 
Published: March 2018

Background: The moment of hospital discharge is a time for vulnerability for many patients and might jeopardize their safety. We found that the current structure of the discharge card at Soba University Hospital (SUH) does not improve the quality of the discharge summary. This hinders the delivery of valid, relevant and adequate health information and can negatively affect outpatient care. Methods: We implemented a new discharge card design with structured headings at the Department of Medicine at Soba University Hospital from the beginning of March to April 15th, 2017. This was coupled with educational sessions highlighting the problems that might occur if there were gaps in patient transition from inpatient to outpatient. Results: There was a significant improvement in documentation of the majority (>90%) of the items, including name, age, source of admission treating doctor, diagnosis and medication, but there was a drop in documentation of comorbidities. We also noticed that the new discharge summary format significantly improved the documentation of the majority of the headings (all P values were <0.001), yet, there was a drop in documentation of comorbidities and dates for follow up. Conclusions: Recording of paper-based health records like discharge summaries could be substantially improved by use of well-structured formats and practical training sessions. Improvement is a dynamic process. Some gaps might appear during execution, these need monitoring and continuous improvement to establish sustainability.
Assessment of the Cambridge Neuropsychological Test Automated Battery test in Saudi children with learning disabilities: A case-control study
Authors: Al Backer Nouf , Ateeq Alharbi Koloud , Alfahadi Abdulrahman , Shahid Habib Syed , Bashir Shahid 
Published: March 2018

Background: The neuropsychological tests and its subtests are composed of the motor planning task; simple reaction time task and the intradimensional/extradimensional shift (IED) task from the Cambridge Neuropsychological Test Automated Battery (CANTAB) were developed to examine specific components of cognition. The main objective of this study was to examine the reliability of these CANTAB subtests in pediatric patients with learning disabilities (LD) in Saudi Arabia. Methods: We administered the CANTAB subset test to 92 participants with LD and 68 controls with no LD. The tests performed were motor planning task (MOT), simple reaction time task (SRT) and the intradimensional/extradimensional shift (IED). Results: There was no significant age difference between the case and the control group (case: 9.2 ± 2.4 years versus controls: 9.0 ± 1.6 years, p=0.544). The IED and MOT were significantly longer among patients with LD versus control (p <0.001). LD cases had a longer SRT time than controls (cases: 1050.4 ± 626.5 versus controls: 815.5 ± 133.9, p=0.003). LD patients completed an average of 3.0 stages, than the controls, who were able to complete a mean of 8.4 IED stages (p<0.001). SRT was significantly longer in the case group (965.9 ± 716.4) compared to the controls (747.7 ± 120.7, p=0.014). LD cases made more errors in the motor screening tasks (MOT-Error) compared to the control group (case: 14.6 ± 4.5 versus controls: 12.4 ± 2.7, p<0.001). Conclusion: Patients with LD have poor CANTAB subtest results. If these CANTAB subtests do measure cognitive function, this adds to the accumulating evidence of cognitive impairment association in LD, and such studies should remain an active area of research.
Obstructive sleep apnea as an independent predictor of postoperative delirium and pain: protocol for an observational study of a surgical cohort
Authors: Strutz Patricia , Tzeng William , Arrington Brianna , Kronzer Vanessa , McKinnon Sherry , Ben Abdallah Arbi , Haroutounian Simon , Avidan Michael S. 
Published: March 2018

Introduction: Postoperative delirium and pain are common complications in adults, and are difficult both to prevent and treat. Obstructive sleep apnea (OSA) is prevalent in surgical patients, and has been suggested to be a risk factor for postoperative delirium and pain. OSA also might impact pain perception, and alter pain medication requirements. This protocol describes an observational study, with the primary aim of testing whether OSA is an independent predictor of postoperative complications, focusing on (i) postoperative incident delirium and (ii) acute postoperative pain severity. We secondarily hypothesize that compliance with prescribed treatment for OSA (typically continuous positive airway pressure or CPAP) might decrease the risk of delirium and the severity of pain. Methods and analysis: We will include data from patients who have been enrolled into three prospective studies: ENGAGES, PODCAST, and SATISFY-SOS. All participants underwent general anesthesia for a non-neurosurgical inpatient operation, and had a postoperative hospital stay of at least one day at Barnes Jewish Hospital in St. Louis, Missouri, from February 2013 to December 2017. Patients included in this study have been assessed for postoperative delirium and pain severity as part of the parent studies. In the current study, determination of delirium diagnosis will be based on the 3-minute Diagnostic Confusion Assessment Method, and the Visual Analogue Pain Scale will be used for pain severity. Data on OSA diagnosis, OSA risk and compliance with treatment will be obtained from the preoperative assessment record. Other variables that are candidate risk factors for delirium and pain will also be extracted from this record. We will use logistic regression to test whether OSA independently predicts postoperative delirium and linear regression to assess OSAs relationship to acute pain severity. We will conduct secondary analyses with subgroups to explore whether these relationships are modified by compliance with OSA treatment.
Are the early childhood antecedents of men’s external locus of control similar to those of their female partners?
Authors: Golding Jean , Iles-Caven Yasmin , Ellis Genette , Gregory Steven , Nowicki Stephen 
Published: March 2018

Background:The concept of locus of control of reinforcement was introduced by Julian Rotter and has been the focus of intense research for nearly half a century. Surprisingly little research has been directed at clarifying antecedents of locus of control (LOC) orientations in adult men apart from a few small studies. We previously identified a number of independent antecedents associated with women’s LOC, including features of their parents and early childhood. This raised the question as to whether these factors were also associated with the development of LOC in men.Methods:To identify antecedents of LOC orientations in a representative population of women we previously analysed information concerning characteristics of their parents and their own childhood experiences using pregnant women taking part in the Avon Longitudinal Study of Parents and Children (ALSPAC). Here we use the same design to determine whether their male partners have similar antecedents of LOC orientation. As previously, we use a hypothesis-free exposome technique using all available information on the parents and childhood of the individuals.Results:We show that men had many of the same antecedent characteristics as the women – in particular, their mother’s year of birth and father’s social group, being exposed to cigarette smoke prenatally, starting to smoke regularly before the age of 11, and having a friend die were all associated with being external. Associations of internality common to both were warm maternal care, being breast fed, being born in an area other than that where they currently live, attending boarding school and having a parent admitted to hospital.Conclusions:In general, the antecedents of male external and internal personalities have many similarities to those of women, thus providing some features to inform the possible theoretical background as to how LOC might develop over time.
Use of serum and peritoneal CEA and CA19-9 in prediction of peritoneal dissemination and survival of gastric adenocarcinoma patients: are they prognostic factors?
Authors: Hasbahceci M , Malya FU , Kunduz E , Guzel M , Unver N , Akcakaya A 
Published: March 2018

Introduction To evaluate the impact of serum and peritoneal levels of tumour markers on peritoneal carcinomatosis and survival in gastric adenocarcinoma. Materials and methods Patients with gastric adenocarcinoma were evaluated with regard to serum and peritoneal carcinoembryonic antigen (CEA) and CA19-9. Numeric values and groupings based on serum and peritoneal cutoff values were used. Development of peritoneal carcinomatosis, including positive washing cytology, was regarded as main outcome. Gastric cancer outcomes as disease free and overall survival were analysed. Results There were 67 patients with a mean age of 60 ± 11 years. Positive peritoneal washing cytology was significantly associated with serum CA19-9 and high serum CA 19–9 group (P = 0.033 and P = 0.011, respectively). High peritoneal CEA was shown to be significantly associated with peritoneal carcinomatosis (P = 0.032). After a median follow up of 17 months, 48 patients (71.7%) were alive. Patients with peritoneal carcinomatosis showed significant poorer prognosis as shown by overall survival rate of 28.6%. Only serum CEA was significantly associated with lower disease free and overall survival (P = 0.002 and P = 0.001, respectively). Discussion and conclusion Serum CEA is shown to be significantly associated with poor prognosis for gastric cancer patients. Serum level of CA19-9 and high peritoneal CEA levels are significant predictors for positive peritoneal washing cytology and the development of peritoneal carcinomatosis, respectively. Therefore, the possible impact of serum and peritoneal tumor markers especially on the staging and prognosis of gastric cancer remains to be clarified by future studies.
Are we doing better? Barium enema reduction of intussusception
Authors: Pran L , Baijoo S , Rampersad B 
Published: March 2018

Introduction Intussuception remains one of the most common surgical abdominal emergencies in the paediatric population. The aim of this study was first to re-evaluate our non-operative reduction rate of intussusception using multiple interval barium enemas and second to investigate or discuss an audit cycle, providing evidence and validating the modification of clinical practice. Materials and methods This five-year retrospective study performed at one of two institutions at which a paediatric surgical service is offered. Individuals included were all patients under 12-years of age who were diagnosed with intussusception. Factors considered to be influential in the reduction of the intussusception were collected. End points were defined as successful barium enema reduction or surgical intervention. Results were compared with similar research published in 2010. Results Overall prevalence was found to be 12 cases/year, with a sample size of 60 patients, the mean age at presentation of 13.6 months. Barium enema reduction was attempted in 56/60 patients, while 4/60 patients had operative management as a first intervention. Overall reduction rate was 66% (37/56), 78% occurring on first attempt and 22% on the second attempt. There was no evidence of intussusception in 3/19 patients who had operative management as a second intervention. Delayed interval barium enema reduction demonstrated an improved reduction rate of 66% compared with single-use barium enema reduction of 41% (chi square 0.02). Conclusion A significant benefit was achieved by performing delayed interval enema reduction, which contributed to a 61% increased reduction rate, the actual reduction rate approaches 71%. The audit cycle remains of paramount importance to ensure optimum patient care.
Anaemia as a risk stratification tool for symptomatic patients referred via the two-week wait pathway for colorectal cancer
Authors: Mashlab S , Large P , Laing W , Ng O , D’Auria M , Thurston D , Thomson S , Acheson AG , Humes DJ , Banerjea A ,   On behalf of the Nottingham Colorectal Service
Published: March 2018

Introduction Anaemia is associated with cancer. In 2014 a new form was introduced in our department requesting a haemoglobin (Hb) result on every two-week wait referral for suspected colorectal cancer (CRC). The aim of this study was to review the impact of this intervention. In particular, the significance of any evidence of anaemia (without additional indices) was investigated. Methods A review was conducted of 1,500 consecutive suspected CRC referrals recorded prospectively over a 10-month period. Data on demographics, referral Hb, referral criteria and outcomes were analysed. Anaemia was defined according to World Health Organization criteria (Hb <120g/l for women, Hb <130g/l for men). Results Overall, 1,015 patients were eligible for inclusion in the study. Over a third (38.2%) were documented as anaemic on referral. These patients were three times more likely to be diagnosed with CRC than non-anaemic patients (odds ratio [OR]: 3.22, 95% confidence interval [CI]: 1.87–5.57). Using a more stringent threshold (Hb <100g/l for women and <110g/l for men), they were four times more likely to have CRC (OR: 4.27, 95% CI: 2.35–7.75). Almost a quarter (23.7%) were actually anaemic at the time of referral but not referred with anaemia. In this subgroup, there was a 2.8-fold increase in risk of CRC diagnosis compared with non-anaemic patients (adjusted OR: 2.77, 95% CI: 1.55–4.95). Conclusions Nearly a quarter of patients not referred with iron deficiency anaemia had evidence of anaemia and this was still associated with a higher rate of CRC detection. A full blood count alone might help to risk stratify symptoms such as change in bowel habit in patients on urgent pathways and identify those cases most likely to benefit from invasive investigation.
Advanced Whole-Genome Sequencing and Analysis of Fetal Genomes from Amniotic Fluid
Authors: Mao Qing , Chin Robert , Xie Weiwei , Deng Yuqing , Zhang Wenwei , Xu Huixin , Zhang Rebecca Y u , Shi Quan , Peters Erin E , Gulbahce Natali , Li Zhenyu , Chen Fang , Drmanac Radoje , Peters Brock A 
Published: March 2018

Abstract

BACKGROUND
Amniocentesis is a common procedure, the primary purpose of which is to collect cells from the fetus to allow testing for abnormal chromosomes, altered chromosomal copy number, or a small number of genes that have small single- to multibase defects. Here we demonstrate the feasibility of generating an accurate whole-genome sequence of a fetus from either the cellular or cell-free DNA (cfDNA) of an amniotic sample.

METHODS
cfDNA and DNA isolated from the cell pellet of 31 amniocenteses were sequenced to approximately 50× genome coverage by use of the Complete Genomics nanoarray platform. In a subset of the samples, long fragment read libraries were generated from DNA isolated from cells and sequenced to approximately 100× genome coverage.

RESULTS
Concordance of variant calls between the 2 DNA sources and with parental libraries was &gt;96%. Two fetal genomes were found to harbor potentially detrimental variants in chromodomain helicase DNA binding protein 8 (CHD8) and LDL receptor-related protein 1 (LRP1), variations of which have been associated with autism spectrum disorder and keratosis pilaris atrophicans, respectively. We also discovered drug sensitivities and carrier information of fetuses for a variety of diseases.

CONCLUSIONS
We were able to elucidate the complete genome sequence of 31 fetuses from amniotic fluid and demonstrate that the cfDNA or DNA from the cell pellet can be analyzed with little difference in quality. We believe that current technologies could analyze this material in a highly accurate and complete manner and that analyses like these should be considered for addition to current amniocentesis procedures.
Optimization of Binocular Microscope with Micro Digital Camera for Measuring Seminiferous Tubules Epithelium Height
Authors: Sutriyono Sutriyono 
Published: March 2018

Binocular microscope optimization using micro digital camera to measure seminiferous tubules epithelium of mouse testis (<em>Mus muculus</em>) was completed. This research was conducted at Biology Laboratory of Faculty of Science and Technology UIN Sunan Kalijaga. The purpose of this study was to determine the height of the seminiferous tubules epithelium of mouse testis using micro digital camera. A computer was connected with binocular microscope and optilab advance, then calibration of optilab advance were done on objective lens magnification at 4x, 10x and 40x with 10x ocular lens. The analysis used was descriptive analysis. The mean of the seminiferous tubules epithelium height is 105.6 μm. Optimization on computer and binocular microscope with micro digital camera can be used to measure seminiferous tubules epithelium.
Effect of Addition of Soursop Leaf Extract to Ganyong (Canna edulis Ker.) Starch Edible Film and its application in Red Grape Storage Time
Authors: Widyastuti Erni , Sedyadi Endaruji , Prabawati Susy Yunita 
Published: March 2018

<p>This study aimed to determine the effect of addition of Soursop leaf extract to edible film and its effect on the storage time of red grapes. This research had three main steps, soursop leaf extraction, edible film making, and application on red grapes storage time. Soursop leaves extract variation used in this research are 0.5; 1; and 1.5% (w/w total) and the best result was used to coat the red grapes. The results showed that the optimum composition was obtained on the edible film with the addition of 0.5% (w/w total) soursop leaf extract. The composition increased film thickness from 0.03 to 0.08 mm, decreased film’s tensile strength from 11.89 to 8.42 MPa, decreased elongation from 12.71 to 11.03%, decreased the Young Modulus from 0.935 to 0.764 MPa, and decreased the vapor transmission rate from 7.45 to 6.55 g/m<sup>2</sup>.hour. The 50% shrinkage of weight and 50% texture damage are used as parameters to measure the Red grapes storage time. Based on weight shrinkage, red grapes storage time change from 24 days to 29 days by using an edible film coating without addition of extract, an extend to 32 days while using an edible film coating with addition of soursop leaf extract. Based on texture damage, red grapes storage time increased from 13 to 41 days if using an edible film coating without addition of extract, and increased to 40 days using an edible film coating with the addition of soursop leaf extract.</p>
European Communication Monitor 2016 : 10 ans de recherche pan-européenne sur la communication stratégique
Authors: Cotton Anne-Marie 
Published: March 2018

L’équipe de recherche du European Communication Monitor (ECM) publie les résultats de la dixième édition de leurs questionnements sur les développements et les dynamiques de la communication stratégique dans 43 pays d’Europe. Dans l’étude 2016 l’analyse des « big data », des algorithmes en communication, des pratiques en communication propres au coaching et au conseil, de l’engagement des parties prenantes, des influenceurs actifs sur les réseaux sociaux, et des savoir, savoir-faire et savoir-être des professionnels de la communication. 2710 professionnels de la communication ont participé à l’étude. Les nombreuses comparaisons avec les résultats de l’ECM 2013 dénoncent la faible évolution du niveau de compétences moyen des professionnels de la communication à l’exception de la prévention et la gestion des crises sur les réseaux sociaux. Dans une optique de standards de la professionnalisation, les chercheurs ont créé le « comparative excellence framework » (CEF) qui vise à identifier les caractéristiques distinguant les professionnels et identifiant les pratiques d’excellence.
The research team of the European Communication Monitor (ECM) publishes the results of the tenth edition of their pan-European study on the developments and dynamics of strategic communication in 43 European countries. In the 2016 edition, they focused on the analysis of « big data », communication algorithms, communication practices specifically dealing with coaching and consulting, stakeholders engagement, active influencers on social networks, and the knowledge, skills and know-how of communication professionals. 2710 communication professionals participated in the study. The comparisons with the results of the ECM 2013 reveal a weak evolution of the average level of competences of the communication professionals with the exception of the prevention and the management of crises on the social networks. Willing to support professionalisation standards, the researchers have created the comparative excellence framework (CEF), which aims to identify the characteristics distinguishing professionals and identifying best practices.
Quand les professionnels indépendants réinventent l’agence de communication
Authors: Brizard-Kim Kristell 
Published: March 2018

De plus en plus de communicants s’émancipent du modèle « classique » de l’agence de communication, par la création de réseaux, de collectifs, de communautés, parfois liées par un espace de coworking, voire d’entreprises coopératives. Pour ces communicants, il s’agit de reprendre le pouvoir sur la rémunération de leur expertise et sur leur relation au travail, par l’exercice de leur profession en freelance. Les échanges via ces structures vont au-delà de la mutualisation de moyens ou de l’apport d’affaires : le renouveau des collectifs de freelances ou de l’entrepreneuriat collectif en témoigne. Ces nouveaux « Sublimes » questionnent, par leurs collaborations en dehors d’une entreprise commune, le métier même d’agence de communication, la répartition de la marge dégagée, le manque d’adaptation à la demande du client, mais aussi la concurrence et l’esprit de compétition en interne. Les éléments de langage déployés par ces entreprises collaboratives sont ainsi parfois très offensifs, visant directement les agences, dont la plupart de ces professionnels sont pourtant issus. Les freelances tentent ainsi de s’affranchir du modèle économique de l’agence de communication. Ce faisant, ils opèrent un retour à l’adhocratie entrepreneuriale qui présidait aux débuts du métier d’agence.
Communicators are increasingly emancipating themselves from the « classic » model of the communication agency, by creating networks, collectives, communities, sometimes linked by a coworking space or cooperative enterprises. For these professionals, it is a question of regaining power on the remuneration of their expertise and on their relationship to work, through the exercise of their profession as a freelancer. These exchanges via these structures go beyond the pooling of resources or bringing business: the renewal of free-lances’ groups or collective entrepreneurship attests to this. These new « Sublime » are questioning by their collaborations outside of a joint venture, the communication agency business model, the distribution of the margin, a lack of adaptation to customer demand, but also competition and spirit of internal competition. The language elements made by these companies are collaborative and sometimes directly offensive to agencies, while most of these professionals are stem from them. Freelancers are trying to overcome the economic model of the communication agency. In doing so, they operate a return to entrepreneurial adhocracy who presided over the beginnings of the agency business.