bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative, randomized, prospective, two‐center clinical study to evaluate the clinical and esthetic outcomes of two different bone grafting techniques in early implant placement
Authors: Mau Jimmy LianPing , Grodin Evan , Lin Jung‐Jen , Chen Mark Chun‐Jung , Ho Chung‐Han , Cochran David 
Published: October 2018

AbstractBackgroundEarly implant placement combined with simultaneous contour augmentation was able to rebuild stable facial hard‐tissue and soft‐tissue contours that were esthetically pleasing. The purpose of this study was to evaluate the clinical esthetic outcome, when two different bone grafting materials were used.MethodsForty‐eight patients were randomly assigned into two groups. In the control group, autogenous bone was used to cover the exposed implant surface then a layer of deproteinized bovine bone mineral (DBBM) was added. This graft combination was then combined with a collagen membrane. In the test group, the exposed implant surface was covered with a layer of freeze‐dried bone allograft (FDBA) in combination with the collagen membrane. Modified plaque index (mPI), modified sulcular bleeding index (mSBI), probing depth (PD), keratinized mucosa (KM), implant crown length (IC), distance from the implant shoulder radiographic bone‐to‐implant contact (DIB), pink esthetic score (PES), and white esthetic score (WES) were measured at 12‐months post implant loading.ResultsAll 48 implants were clinically successful, and no significant differences were observed in mPI, mSBI, PD, KM, IC, DIB, PES, and WES at 1‐year implant loading. The mean mucosal recessions of test and control group were unchanged, 0 and –0.02 mm, respectively. The mean DIB were –0.32 and –0.21 mm in test and control implants, respectively. The mean totals of PES/WES were 15.29 and 15.33 for the test and control groups, respectively, with no significant difference between groups.ConclusionThis study demonstrated that autogenous bone plus DBBM and FDBA each combined with a collagen membrane both resulted in stable clinical and esthetic outcomes in early implant placement with contour augmentation after 1 year.
Association between periodontitis and spontaneous abortion: A case‐control study
Authors: Chanomethaporn Anchana , Chayasadom Anek , Wara‐aswapati Nawarat , Kongwattanakul Kiattisak , Suwannarong Waraporn , Tangwanichgapong Kamonchanok , Sumanonta Gunniga , Matangkasombut Oranart , Dasanayake Ananda P. , Pitiphat Waranuch 
Published: October 2018

AbstractBackgroundSpontaneous abortion, or miscarriage, is a complication of pregnancy which can severely affect women both physically and psychologically. We investigated the associations of periodontitis and periodontopathic bacteria with spontaneous abortion.MethodsWe conducted a matched case‐control study in two tertiary hospitals in Khon Kaen, Thailand. Cases were 85 women with spontaneous abortion at <20 weeks of gestation matched to 85 controls on age, gestational age, and hospital. Full‐mouth periodontal examinations were performed. Periodontitis was defined as at least one site with probing depth ≥5 mm and clinical attachment level ≥2 mm at the same site. Subgingival plaque samples were collected to determine the levels of Porphyromonas gingivalis, Tannerella forsythia, and Fusobacterium nucleatum using real time polymerase chain reaction.ResultsThe cases were significantly more likely to have periodontitis (50.6%) than the controls (21.2%; P = 0.007). Conditional logistic regression revealed a crude odds ratio (OR) of 4.1 for the association between periodontitis and spontaneous abortion (95% confidence interval [CI] = 1.9–8.9, P = 0.001). The OR decreased, but was still significant, after controlling for previous miscarriage (OR = 3.3, 95% CI = 1.4–7.8, P = 0.006). There was no significant association between the levels of periodontopathic bacteria and spontaneous abortion. Increased levels of P. gingivalis and F. nucleatum were associated with periodontitis in both case and control groups. Association between increased T. forsythia levels and periodontitis was observed only in the case women.ConclusionsPeriodontitis was more common in women with spontaneous abortions as compared with matched controls. Levels of periodontopathic bacteria was not associated with spontaneous abortion in this population.
Temperature dependence of the Raman dispersion of Sr2Nb2O7: Influence of an electric field during the synthesis
Authors: Alanis Javier , Rodríguez‐Aranda M. C. , Rodríguez Ángel G. , Ojeda‐Galván Hiram Joazet , Mendoza María Eugenia , Navarro‐Contreras Hugo R. 
Published: October 2018

AbstractWe report on the preparation and structural characterization of powder samples of the perovskite‐slab layered polycrystalline Sr2Nb2O7 (hereafter named SNO) ferroelectric compound. Comparison is performed on samples grown without (SNO) and with an applied electric field of 3.34 kV/cm (SNOE). The Raman effect produced by these samples as a function of temperature, from 27°C (room temperature) to 400°C is presented and discussed. Significant differences are observed and discussed among SNO and SNOE. The electric field promotes the growth of platelets, preferentially oriented along the (0b0) planes. The temperature coefficients of 35 phonon wavenumbers were determined for both samples. A majority of the phonons exhibit monotonic wavenumber softening's with increasing temperatures, but a significant number of them show discontinuities on the wavenumber temperature slopes at two temperatures 215°C and 307 ± 5°C. The first temperature corresponds to the well‐known incommensurate phase to the ferroelectric phase transition (Phases III to II). The second temperature is indicative of an unreported phase transition for both the SNO and SNOE samples. For the sample SNOE, a phonon f7 (at 121 cm−1 at room temperature) displays a behavior that may be indicative of the existence of another ordering parameter that vanishes at 488 ± 5°C in the SNOE sample, induced by the electric field applied during the growth. The phonon broadenings with temperature are explained in terms of the Klemens model, which considers that the broadenings are due to the thermal expansion of the lattice, with a substantial contribution in magnitude from anharmonic phonon–phonon interactions.
Microencapsulated food‐grade antioxidant applied as a preservative of peanut seed quality in microcosm‐ and pilot‐scale trials
Authors: Girardi Natalia Soledad , Garcia Daiana , Passone María Alejandra , Nesci Andrea , García Julián , Etcheverry Miriam 
Published: October 2018

AbstractBACKGROUNDIn Argentina, peanuts are stored for 3–6 months. It is important to avoid proliferation of fungi and insect pests during this period. In this study, the potential of butylated hydroxyanisole (BHA) microcapsules to conserve peanut kernels was evaluated in microcosms and on a pilot scale.RESULTSIn microcosm assays, microcapsules containing BHA at a dose of 1802 µg g−1 reduced 37% of total fungal count. Higher reductions (77–100%) were obtained with a combined treatment with BHA formulation (1802 µg g−1) plus fungicide (methyl thiophanate 0.0100 g L−1 and metalaxyl 0.0133 g L−1). However, germination levels of peanut seeds treated with the BHA formulation were less than 6% throughout the incubation time. In pilot‐scale trials, the storage conditions allowed the control of fungal development and insect proliferation. Quantifiable levels of BHA were also detected throughout the entire storage period. The combined treatment significantly reduced fungal contamination at 2 months of storage (C1‐2015: 37.41%; C1‐2016: 28.48%; C2‐2016: 45.02%). Seed germination of unshelled stored peanuts was not affected by the formulation.CONCLUSIONThe application of the BHA formulation during storage combined with pre‐seeding treatment could be an appropriate strategy to maintain the quality of the peanut kernels destined for seed. © 2018 Society of Chemical Industry
Effects of thawed depth on the sediment transport capacity by melt water on partially thawed black soil slope
Authors: Gao Xiaofeng , Li Fahu , Chen Chao , Ban Yunyun , Gao Yuan 
Published: October 2018

AbstractThis study proposed an apparatus for measuring the sediment transport capacity, which is an important parameter for rill erosion prediction and modeling. Laboratory experiments were conducted to measure the sediment transport capacity of partially thawed black soil slope under different hydraulic conditions and thawed depths (five slope gradients of 5°, 10°, 15°, 20°, and 25°; three flow discharges of 1, 2, and 4 dm3 min−1; and four thawed depths of 1, 2, 5, and 10 cm). The effect of thawed depth on sediment transport capacity was quantified with experimental data under different slope gradients and flow discharges. A quadratic model was used to relate sediment transport capacity to thawed depth, slope gradient, and flow discharge, and its key factors that influenced sediment transport capacity were determined by using stepwise regression. Results showed that sediment transport capacity decreased with the increase of thawed depth from 1 to 5 cm, but it tended to be steady when the thawed depth was greater than 5 cm. Model‐fitting results showed that sediment transport capacity was positively correlated with slope gradient and flow discharge but negatively correlated with thawed depth. The proposed method and experimental device solved the difficulties of insufficient sediment supply on the measurement of sediment transport capability, and it can be used to measure the sediment transport capacity of concentrated water flow under different conditions of slope gradient, thawed depth, and flow discharge. The method is helpful to the research of erosion process of partially thawed soil under concentrated water.
Comparing Rhizon samplers and centrifugation for pore‐water separation in studies of the marine carbonate system in sediments
Authors: Steiner Zvi , Lazar Boaz , Erez Jonathan , Turchyn Alexandra V. 
Published: October 2018

AbstractAn accurate description of the carbonate system in pore waters is valuable in studies involving the degradation of sedimentary organic matter, recrystallization of calcium carbonate minerals, calculations of mineral saturation state, and cycling of ions affected by pH. Here, we analyze water chemistry of pore water extracted using centrifugation and Rhizon samplers from hemipelagic sediments in the Gulf of Aqaba, Red Sea, and a shallow salt marsh from Norfolk, England. In both study areas, the data are internally consistent for each pore‐water separation technique, but the measured isotopic composition of the dissolved inorganic carbon (δ13C[DIC]) differs between the two techniques. We performed laboratory experiments that show that both Rhizons and centrifugation are prone to degassing of CO2 enriched with 12C. We suggest that during sampling with Rhizons, air fills the voids left by extracted pore water; combined with the membrane's design to exclude air, some of the aqueous CO2 diffuses into these air bubbles instead of the sampler. Rhizons produce reliable calcium, strontium, manganese, and barium concentration data when soaked in deionized water and then flushed with the sample immediately prior to sampling. However, pore‐water extractions with Rhizons are less reliable for analyses of pH and δ13C[DIC]. Centrifugation produces reliable carbonate chemistry and major element data when tubes are fully filled without headspace and sealed tightly. Working in CO2 low/free atmosphere (e.g., N2 glovebox) enhances the chance of losing CO2 from the sample in both sampling techniques due to increased negative gradient of CO2 between the core and its surrounding.
On total capacity of k‐out‐of‐n systems with random weights
Authors: Zhang Yiying , Ding Weiyong , Zhao Peng 
Published: October 2018

AbstractIn engineering applications, many reliability systems can be modeled as k‐out‐of‐n systems with components having random weights. Before putting such kind of system into a working state, it is of great significance for a system designer to find out the optimal assembly of the random weights to the components. In this article, we investigate the performance levels of k‐out‐of‐n systems with random weights. Optimal assembly policies are obtained by maximizing the total capacity according to different criteria, including the usual stochastic order, the increasing convex [concave] order, and the expectation order. Based on the optimal assembly strategy derived by maximizing the expected total capacity, we further investigate stochastic properties of the resulting weighted system with respect to the vector of expectations of random weights. Numerical examples are provided to highlight our theoretical findings as well.
Integration of MRI and MRS approaches to monitor molecular imaging and metabolomic effects of trabectedin on a preclinical ovarian cancer model
Authors: Canese Rossella , Palombelli Gianmauro , Chirico Mattea , Sestili Paola , Bagnoli Marina , Canevari Silvana , Mezzanzanica Delia , Podo Franca , Iorio Egidio 
Published: October 2018

Although several drugs are available to treat recurrences of human epithelial ovarian cancer (EOC), clinical responses often remain short lived and lead to only marginal improvements in patients' survival. One of the new drugs proposed for recurrent platinum‐resistant EOC patients is trabectedin (Trab), a marine‐derived antitumor agent initially isolated from the tunicate Ecteinascidia turbinata and currently produced synthetically. Predictive biomarkers of therapy response to this drug and the potential use of non‐invasive functional MRI and MRS approaches for an early assessment of Trab efficacy have not yet been evaluated, although they might be relevant for improving the clinical management of EOC patients. In the present work we combined functional and spectroscopic magnetic resonance technologies, such as in vivo diffusion‐weighted MRI and 1H MRS, with ex vivo high resolution MRS (HR‐MRS) metabolomic analyses, with the aim of identifying new pharmacodynamic markers of Trab effectiveness on well characterized, highly aggressive human SKOV3.ip (a HER2‐enriched cell variant derived from SKOV3 cells) EOC xenografts. In vivo treatment with Trab (three consecutive weekly 0.2 mg/kg i.v. injections) resulted in the following: (1) a significant reduction of in vivo tumor growth, along with the formation in cancer lesions of diffuse hyper‐intense areas detected by T2‐weighted MRI and attributed to necrosis, in agreement with histopathology findings; (2) significant increases in the apparent diffusion coefficient mean and median values versus saline‐treated control tumors; and (3) a significant reduction in the choline‐containing metabolites' signal detected by quantitative in vivo MRS. Multivariate and quantitative HR‐MRS analyses on ex vivo tissue samples revealed Trab‐induced alterations in phospholipid and glucose metabolism identified as a decrease in phosphocholine and an increase in lactate. Collectively, these data identify Trab‐induced functional MRI and MRS alterations in EOC models as a possible basis for further developments of these non‐invasive imaging methods to improve the clinical management of EOC patients.
The tyrosine phosphatase Shp‐2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration
Authors: Gagné‐Sansfacon Jessica , Langlois Ariane , Langlois Marie‐Josée , Coulombe Geneviève , Tremblay Sarah , Vaillancourt‐Lavigueur Vanessa , Qu Cheng‐Kui , Menendez Alfredo , Rivard Nathalie 
Published: October 2018

AbstractThe Src homology‐2 domain‐containing tyrosine phosphatase 2 (SHP‐2) regulates many cellular processes, including proliferation, differentiation and survival. Polymorphisms in the gene encoding SHP‐2 are associated with an increased susceptibility to develop ulcerative colitis. We recently reported that intestinal epithelial cell (IEC)‐specific deletion of Shp‐2 in mice (Shp‐2IEC‐KO) leads to chronic colitis and colitis‐associated cancer. This suggests that SHP‐2‐dependent signaling protects the colonic epithelium against inflammation and colitis‐associated cancer development. To verify this hypothesis, we generated mice expressing the Shp‐2 E76K activated form specifically in IEC. Our results showed that sustained Shp‐2 activation in IEC increased intestine and crypt length, correlating with increased cell proliferation and migration. Crypt regeneration capacity was also markedly enhanced, as revealed by ex vivo organoid culture. Shp‐2 activation alters the secretory cell lineage, as evidenced by increased goblet cell numbers and mucus secretion. Notably, these mice also demonstrated elevated ERK signaling in IEC and exhibited resistance against both chemical‐ and Citrobacter rodentium‐induced colitis. In contrast, mice with IEC‐specific Shp‐2 deletion displayed reduced ERK signaling and rapidly developed chronic colitis. Remarkably, expression of an activated form of Braf in Shp‐2‐deficient mice restored ERK activation, goblet cell production and prevented colitis. Altogether, our results indicate that chronic activation of Shp‐2/ERK signaling in the colonic epithelium confers resistance to mucosal erosion and colitis. © 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Translating N‐Glycan Analytical Applications into Clinical Strategies for Ovarian Cancer
Authors: Briggs Matthew T. , Condina Mark R. , Klingler‐Hoffmann Manuela , Arentz Georgia , Everest‐Dass Arun V. , Kaur Gurjeet , Oehler Martin K. , Packer Nicolle H. , Hoffmann Peter 
Published: October 2018

AbstractProtein glycosylation, particularly N‐linked glycosylation, is a complex posttranslational modification (PTM), which plays an important role in protein folding and conformation, regulating protein stability and activity, cell–cell interaction, and cell signaling pathways. This review focuses on analytical techniques, primarily MS‐based techniques, to qualitatively and quantitatively assess N‐glycosylation while successfully characterizing compositional, structural, and linkage features with high specificity and sensitivity. The analytical techniques explored in this review include LC–ESI–MS/MS and MALDI time‐of‐flight MS (MALDI‐TOF‐MS), which have been used to analyze clinical samples, such as serum, plasma, ascites, and tissue. Targeting the aberrant N‐glycosylation patterns observed in MALDI–MS imaging (MSI) offers a platform to visualize N‐glycans in tissue‐specific regions. The studies on the intra‐patient (i.e., a comparison of tissue‐specific regions from the same patient) and inter‐patient (i.e., a comparison of tissue‐specific regions between different patients) variation of early‐ and late‐stage ovarian cancer (OC) patients identify specific N‐glycan differences that improve understanding of the tumor microenvironment and potentially improve therapeutic strategies for the clinic.
Spatial distribution of beetle attack and its association with mango sudden decline: an investigation using geostatistical tools
Authors: Pereira Rogério M , da Silva Galdino Tarcísio V , Rodrigues‐Silva Nilson , da Silva Ricardo S , de Souza Thadeu C , Picanço Marcelo C 
Published: October 2018

AbstractBACKGROUNDCeratocystis fimbriata recognized among the species that induce mango sudden decline (MSD), causes plant death within a short period. The beetles Hypocryphalus mangiferae and Xyleborus affinis (Curculionidae: Scolytinae) are the vectors of MSD. Thorough understanding of the spatial distribution of the pest is crucial to designing control techniques and drawing up sampling plans. This study aimed to identify the beetles and their dispersal pattern in mango trees in MSD‐infected commercial orchards, and the association with the severity of the C. fimbriata infestation.RESULTSBeetle attacks were observed to be maximal on mango tree trunks revealing severe infestation. From the geostatistical analysis, an aggregated pattern was evident as galleries in the trunks and branches of mango trees.CONCLUSIONThis is the first study to employ geostatic tools on a plant scale in MSD‐infested mango orchards and to study the incidence of beetle attack. The results may prove a highly effective tool for mango growers, with respect to the management of beetles and MSD, as this will facilitate the monitoring of specific sites where the frequency of beetles and MSD is high. © 2018 Society of Chemical Industry
Selecting a near‐optimal design for multiple criteria with improved robustness to different user priorities
Authors: Burke Sarah E. , Lu Lu , Anderson‐Cook Christine M. , Montgomery Douglas C. 
Published: October 2018

AbstractIn a decision‐making process, relying on only one objective can often lead to oversimplified decisions that ignore important considerations. Incorporating multiple, and likely competing, objectives is critical for balancing trade‐offs on different aspects of performance. When multiple objectives are considered, it is often hard to make a precise decision on how to weight the different objectives when combining their performance for ranking and selecting designs. We show that there are situations when selecting a design with near‐optimality for a broad range of weight combinations of the criteria is a better test selection strategy compared with choosing a design that is strictly optimal under very restricted conditions. We propose a new design selection strategy that identifies several top‐ranked solutions across broad weight combinations using layered Pareto fronts and then selects the final design that offers the best robustness to different user priorities. This method involves identifying multiple leading solutions based on the primary objectives and comparing the alternatives using secondary objectives to make the final decision. We focus on the selection of screening designs because they are widely used both in industrial research, development, and operational testing. The method is illustrated with an example of selecting a single design from a catalog of designs of a fixed size. However, the method can be adapted to more general designed experiment selection problems that involve searching through a large design space.