bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structure evaluation of the implementation of geriatric models in primary care: A multiple-case study of models involving Advanced Geriatric Nurses in five municipalities in Norway
Authors: Antypas Konstantinos , Kirkevold Marit 
Published: July 2019

Abstract
Background

The Advanced Geriatric Nurse role recently has been introduced into Norway’s primary healthcare system, and our study’s purpose was to examine the implementation of models of care developed to integrate the Advanced Geriatric Nurse role into primary care. With a structure evaluation, we tried to identify conditions that affect the implementation of different models of care and understand how these conditions affected the realisation of each model’s intentions and goals.

Methods

An embedded multiple-case study was used that included five Norwegian municipalities and seven AGNs. The study included data from August 2014 through September 2018. We used data from 25 semi-structured face-to-face interviews with AGNs and stakeholders, documents and statistical information. We used a cross-case procedure with an emphasis on case findings for the analysis of the multiple case study.

Results

We analysed the structure-related conditions on two levels: the meso-level and the micro-level. On the meso-level, we found that the conditions that affected the implementation of the different models of care were related to each municipality’s structural characteristics, stakeholders’ involvement in the design of the models of care, the clarity of the models and their goals, the evaluation of the models and their adaptation. At the micro-level, we found that the conditions that affected the models’ implementation were related to the collaboration within the implemented models of care, the role clarity of Advanced Geriatric Nurses themselves and adjustments within the models.

Conclusions

The implementation of the AGN role in Norway seems to have been implemented in ways that can impact patients and municipalities positively. Potential improvements include extensive stakeholder involvement, improved roles, goal clarity and better documentation of structures and outcomes. The models’ dynamic nature seemed to be a beneficial characteristic, but adaptation should be systematic and a necessary time should be considered for a new model of care to be integrated and produce results.
Correlation between Karyotype, Puberty Stage and Volume of Reproductive Organs in Turner Syndrome: The First Transrectal Sonography Study in Indonesia
Authors: Novina Novina , Sumapraja Kanadi , Gunardi Hartono , Pulungan Aman B 
Published: July 2019

Abstract
Background: Turner syndrome is characterized by the absence of part of or the entire X chromosome in a woman, resulting in short stature, gonadal dysgenesis, and congenital anomaly. Based on karyotype, Turner syndrome is categorized as classical (45XO) and mosaic. The aim of this study is to evaluate the correlation of the karyotype with the puberty stage, volume of the uterus, and ovary in Turner syndrome’s adolescent with estrogen therapy.
Methods: Analytic correlative cross-sectional study was done in Pediatric Endocrinology Outpatient Clinic at Cipto Mangunkusumo National Hospital since July to December 2018. Pubertal staging based on Tanner stage, uterine, and ovary volume were measured by transrectal sonography.
Results: Of 21 study subjects, 8 were having classical karyotype and 13 were having mosaic karyotype in 12–21-year-old subjects. There was a significant correlation between karyotype and Tanner M stage (mammae stage) (p = 0.035). Breasts development in Turner syndrome with mosaic karyotype showed better development compared to classic karyotype. No significant correlation was found between karyotype and uterine and ovary volume in sonography transrectally.
Conclusion: Karyotype correlates to mammae stage of Tanner but not in uterine and ovary volume in adolescents with Turner syndrome who underwent estrogen therapy.
DART-seq
Authors: De Vlaminck Iwijn , Saikia Mridusmita , Burnham Philip , Keshavjee Sara H. , Wang Michael F. Z. , Heyang Michael , Moral-Lopez Pablo , Hinchman Meleana M. , Danko Charles G. , Parker John S. L. 
Published: July 2019

Abstract

Here we describe the step-by-step protocol of Droplet Assisted RNA Targeting by single cell sequencing \(DART-seq). DART-seq allows simultaneous multiplexed amplicon sequencing and transcriptome analysis in single cells. Using a simple and quick modification of commercially available barcoded beads we have expanded the application of droplet microfluidics based high throughput single cell RNA sequencing technology to include non-polyadenylated RNA transcripts. Specific probes targeting RNA of interest were attached to the beads using a T4 DNA Ligase based enzymatic reaction.The modified DART-seq beads were then used in standard Drop-seq platform to generate single cell libraries for sequencing. We have applied DART-seq to analyze reovirus RNA sequences in infected murine L cells. As a second application we used DART-seq to investigate the B cell repertoire in human peripheral blood mononuclear cell \(PBMC) samples.
Assessing the Relationship between Cognitive Load and the Usability of a Mobile Augmented Reality Tutorial System: A Study of Gender Effects
Authors: IBİLİ Emin , BİLLİNGHURST Mark 
Published: July 2019

In this study, the relationship between the
usability of a mobile Augmented Reality (AR) tutorial system and cognitive load
was examined. In this context, the relationship between perceived usefulness,
the perceived ease of use, and the perceived natural interaction factors and
intrinsic, extraneous, germane cognitive load were investigated. In addition, the effect of gender on this
relationship was investigated. The research results show that there was a
strong relationship between the perceived ease of use and the extraneous load
in males, and there was a strong relationship between the perceived usefulness and
the intrinsic load in females. Both the perceived usefulness and the perceived
ease of use had a strong relationship with the germane cognitive load.
Moreover, the perceived natural interaction had a strong relationship with the
perceived usefulness in females and the perceived ease of use in males. This
research will provide significant clues to AR software developers and
researchers to help reduce or control cognitive load in the development of
AR-based instructional software.
Physiopathological Premises to Nuclear Medicine Imaging of Pancreatic Neuroendocrine Tumours
Authors: Cuccurullo Vincenzo , Di Stasio Giuseppe Danilo , Mansi Luigi 
Published: July 2019

Background:Pancreatic Neuroendocrine Tumors (P-NETs) are a challenge in terms of both diagnosis and therapy; morphological studies need to be frequently implemented with nonstandard techniques such as Endoscopic Ultrasounds, Dynamic CT, and functional Magnetic Resonance.Discussion:The role of nuclear medicine, being scarcely sensitive F-18 Fluorodeoxyglucose, is mainly based on the over-expression of Somatostatin Receptors (SSTR) on neuroendocrine tumor cells surface. Therefore, SSTR can be used as a target for both diagnosis, using radiotracers labeled with gamma or positron emitters, and therapy. SSTRs subtypes are capable of homo and heterodimerization in specific combinations that alter both the response to ligand activation and receptor internalization.Conclusion:Although agonists usually provide efficient internalization, also somatostatin antagonists (SS-ANTs) could be used for imaging and therapy. Peptide Receptor Radionuclide Therapy (PRRT) represents the most successful option for targeted therapy. The theranostic model based on SSTR does not work in insulinoma, in which different radiotracers such as F-18 FluoroDOPA or tracers for the glucagon-like peptide-1 receptor have to be preferred.
Imaging of Pancreatic-Neuroendocrine Tumours: An Outline of Conventional Radiological Techniques
Authors: Zamir Muhammad Affan , Hakim Wasim , Yusuf Siraj , Thomas Robert 
Published: July 2019

IIntroduction:Pancreatic Neuroendocrine Tumours (p-NETs) are an important disease entity and comprise of peptide-secreting tumours often with a functional syndrome.:Accounting for a small percentage of all pancreatic tumours, they have a good overall survival rate when diagnosed early, with surgery being curative. The role of nuclear medicine in the diagnosis and treatment of these tumours is evident. However, the vast majority of patients will require extensive imaging in the form of conventional radiological techniques. It is important for clinicians to have a fundamental understanding of the p-NET appearances to aid prompt identification and to help direct management through neoplastic staging.Methods:This article will review the advantages and disadvantages of conventional radiological techniques in the context of p-NETs and highlight features that these tumours exhibit.Conclusion:Pancreatic neuroendocrine tumours are a unique collection of neoplasms that have markedly disparate clinical features but similar imaging characteristics. Most p-NETs are small and welldefined with homogenous enhancement following contrast administration, although larger and less welldifferentiated tumours can demonstrate areas of necrosis and cystic architecture with heterogeneous enhancement characteristics.:Prognosis is generally favourable for these tumours with various treatment options available. However, conventional radiological techniques will remain the foundation for the initial diagnosis and staging of these tumours, and a grasp of these modalities is extremely important for physicians.
Self-micro Emulsifying Drug Delivery System “SMEDDS” for Efficient Oral Delivery of Andrographolide
Authors: Nallamolu Sivaram , Jayanti Vijaya R. , Chitneni Mallikarjun , Khoon Liew Y. , Kesharwani Prashant 
Published: July 2019

Objective:
Andrographolide has potent anticancer and antimicrobial activity; however, its
clinical application has been limited due to its poor water solubility as well as lack of appropriate formulation.
The objective of this investigation was to formulate Self–Micro Emulsifying Drug Delivery
System (SMEDDS) of andrographolide and explore its oral drug delivery aptitudes.

Methods:
Andrographolide SMEDDS was optimized by ternary phase approach and studied for various
in vitro characteristics: Particle size, electron microscopy, polydispersity index, surface charge, dilution
effect, pH stability, freeze-thaw effect, dissolution profile and stability studies. Further, antimicrobial
and cytotoxic performance of andrographolide SMEDDS were evaluated in MCF–7 breast cancer cell
lines and methicillin-resistant microorganisms, respectively.

Results:
An optimized SMEDDS formulation of andrographolide was successfully prepared and evaluated
for its drug delivery potential. The solubility of andrographolide in the developed SMEDDS formulation
was increased significantly, and the drug loading was enough for making this drug clinically
applicable. The andrographolide SMEDDS formulation competitively inhibited the growth of microorganisms
and showed enhanced anti–microbial activity against MRSA microorganisms.

Conclusion:
The SMEDDS strategy represents one of the best approaches to deliver andrographolide
via oral route, while resolving its solubility limitations.
Recent Patents on Tension Control Device of Wire Electrode in WEDM
Authors: Xie Baocheng , Ni Xiaowei , Jiang Jingang , Zhang Yuan , Dai Ye , Ren Shengle 
Published: July 2019

Background:
WEDM (Wire Electrical Discharge Machining) is widely used to machine
difficult-to-machine materials, such as high-strength and high-brittle materials. The research on tension
control device of the wire electrode is mainly to improve the machining precision and surface quality of
WEDM.

Objective:
To meet the growing demand for processing of difficult-to-machine materials, such as highstrength
and high-brittle materials, the machining precision and surface quality of WEDM are improved
continuously.

Methods:
This paper reviews various representative patents related to the tension control device of wire
electrode in WEDM.

Results:
Through retracing the characteristics of different types of the tension control device of wire
electrode in WEDM, the main problems existing in the current development are concluded and analyzed.
The development trend of patents on the tension control device of wire electrode in WEDM is
discussed.

Conclusion:
The optimization and development of the tension control device of wire electrode in
WEDM are beneficial to improve the machining precision and surface quality of WEDM. More related
patents on the tension control device of wire electrode in WEDM will be invented.
Adapting Mobile and Wearable Technology to Provide Support and Monitoring in Rehabilitation for Dementia: Feasibility Case Series
Authors: Thorpe Julia , Forchhammer Birgitte Hysse , Maier Anja M 
Published: July 2019

Background
Mobile and wearable devices are increasingly being used to support our everyday lives and track our behavior. Since daily support and behavior tracking are two core components of cognitive rehabilitation, such personal devices could be employed in rehabilitation approaches aimed at improving independence and engagement among people with dementia.

Objective
The aim of this work was to investigate the feasibility of using smartphones and smartwatches to augment rehabilitation by providing adaptable, personalized support and objective, continuous measures of mobility and activity behavior.

Methods
A feasibility study comprising 6 in-depth case studies was carried out among people with early-stage dementia and their caregivers. Participants used a smartphone and smartwatch for 8 weeks for personalized support and followed goals for quality of life. Data were collected from device sensors and logs, mobile self-reports, assessments, weekly phone calls, and interviews. This data were analyzed to evaluate the utility of sensor data generated by devices used by people with dementia in an everyday life context; this was done to compare objective measures with subjective reports of mobility and activity and to examine technology acceptance focusing on usefulness and health efficacy.

Results
Adequate sensor data was generated to reveal behavioral patterns, even for minimal device use. Objective mobility and activity measures reflecting fluctuations in participants’ self-reported behavior, especially when combined, may be advantageous in revealing gradual trends and could provide detailed insights regarding goal attainment ratings. Personalized support benefited all participants to varying degrees by addressing functional, memory, safety, and psychosocial needs. A total of 4 of 6 (67%) participants felt motivated to be active by tracking their step count. One participant described a highly positive impact on mobility, anxiety, mood, and caregiver burden, mainly as a result of navigation support and location-tracking tools.

Conclusions
Smartphones and wearables could provide beneficial and pervasive support and monitoring for rehabilitation among people with dementia. These results substantiate the need for further investigation on a larger scale, especially considering the inevitable presence of mobile and wearable technology in our everyday lives for years to come.
Physician Decision-Making Patterns and Family Presence: Cross-Sectional Online Survey Study in Japan
Authors: Tsuda Kenji , Higuchi Asaka , Yokoyama Emi , Kosugi Kazuhiro , Komatsu Tsunehiko , Kami Masahiro , Tanimoto Tetsuya 
Published: July 2019

Background
Due to a low birth rate and an aging population, Japan faces an increase in the number of elderly people without children living in single households. These elderly without a spouse and/or children encounter a lack of caregivers because most sources of care for the elderly in Japan are not provided by private agencies but by family members. However, family caregivers not only help with daily living but are also key participants in treatment decision making. The effect of family absence on treatment decision making has not been elucidated, although more elderly people will not have family members to make surrogate decisions on their behalf.

Objective
The aim is to understand the influence of family absence on treatment decision making by physicians through a cross-sectional online survey with three hypothetical vignettes of patients.

Methods
We conducted a cross-sectional online survey among Japanese physicians using three hypothetical vignettes. The first vignette was about a 65-year-old man with alcoholic liver cirrhosis and the second was about a 78-year-old woman with dementia, both of whom developed pneumonia with consciousness disturbance. The third vignette was about a 70-year-old woman with necrosis of her lower limb. Participants were randomly assigned to either of the two versions of the questionnaires—with family or without family—but methods were identical otherwise. Participants chose yes or no responses to questions about whether they would perform the presented medical procedures.

Results
Among 1112 physicians, 454 (40.8%) completed the survey; there were no significant differences in the baseline characteristics between groups. Significantly fewer physicians had a willingness to perform dialysis (odds ratio [OR] 0.55, 95% CI 0.34-0.80; P=.002) and artificial ventilation (OR 0.51, 95% CI 0.35-0.75; P<.001) for a patient from vignette 1 without family. In vignette 2, fewer physicians were willing to perform artificial ventilation (OR 0.59, 95% CI 0.39-0.90; P=.02). In vignette 3, significantly fewer physicians showed willingness to perform wound treatment (OR 0.51, 95% CI 0.31-0.84; P=.007), surgery (OR 0.35, 95% CI 0.22-0.57; P<.001), blood transfusion (OR 0.45, 95% CI 0.31-0.66; P<.001), vasopressor (OR 0.49, 95% CI 0.34-0.72; P<.001), dialysis (OR 0.38, 95% CI 0.24-0.59; P<.001), artificial ventilation (OR 0.25, 95% CI 0.15-0.40; P<.001), and chest compression (OR 0.29, 95% CI 0.18-0.47; P<.001) for a patient without family.

Conclusions
Elderly patients may have treatments withheld because of the absence of family, highlighting the potential importance of advance care planning in the era of an aging society with a declining birth rate.
Codifying Online Social Support for Breast Cancer Patients: Retrospective Qualitative Assessment
Authors: Mikal Jude P , Grande Stuart W , Beckstrand Michael J 
Published: July 2019

Background
Social media has emerged as the epicenter for exchanging health-related information, resources, and emotional support. However, despite recognized benefits of social media for advancing health-promoting support exchange, researchers have struggled to differentiate between the different ways social support occurs and is expressed through social media.

Objective
The objective of this study was to develop a fuller understanding of social support exchange by examining the ways in which breast cancer patients discuss their health needs and reach out for support on Facebook and to develop a coding schema that can be useful to other social media researchers.

Methods
We conducted a retrospective qualitative assessment of text-based social support exchanges through Facebook among 30 breast cancer survivors. Facebook wall data were systematically scraped, organized, coded, and characterized by whether and which types of support were exchanged. Research questions focused on how often participants posted related to cancer, how often cancer patients reached out for support, and the relative frequency of informational, instrumental, or socioemotional support requests broadcast by patients on the site.

Results
A novel ground-up coding schema applied to unwieldy Facebook data successfully identified social support exchange in two critical transitions in cancer treatment: diagnosis and transition off cancer therapy. Explanatory coding, design, and analysis processes led to a novel coding schema informed by 100,000 lines of data, an a priori literature review, and observed online social support exchanges. A final coding schema permits a compelling analysis of support exchange as a type of peer community, where members act proactively to buffer stress effects associated with negative health experiences. The coding schema framed operational definitions of what support meant and the forms each type of support could take in social media spaces.

Conclusions
Given the importance of social media in social interaction, support exchange, and health promotion, our findings provide insight and clarity for researchers into the different forms informational, resource, and emotional support may take in Web-based social environments. Findings support broader continuity for evaluating computer-mediated support exchange.
Development of Ovarian Tissue Autograft to Restore Ovarian Function: Protocol for a French Multicenter Cohort Study
Authors: Pretalli Jean-Baptiste , Frontczak Franck Sophie , Pazart Lionel , Roux Christophe , Amiot Clotilde ,   DATOR Group
Published: July 2019

Background
Sterility is a major late effect of radiotherapy and chemotherapy treatments. Iatrogenic sterility is often permanent and greatly impacts long-term quality of life. Ovarian tissue cryopreservation (OTC) performed before gonadotoxic treatments with subsequent autograft is a method of fertility preservation available for girls and women. Its application in prepubertal girls is of particular value as it is the only possible approach in this patient group. In addition, it does not require a delay in cancer therapy and no ovarian stimulation is needed.

Objective
The primary aim of this protocol is to help increase the implementation of ovarian tissue autografting in France. Knowledge is still lacking regarding the efficacy of ovarian transplantation in restoring ovarian function and regarding the safety of this procedure, especially the risk of cancer cell reseeding in certain types of cancer. A secondary aim of this study is to generate data to improve our understanding of these two essential aspects.

Methods
The DATOR (Development of Ovarian Tissue Autograft in Order to Restore Ovarian Function) study is ongoing in 17 university hospitals. The DATOR protocol includes the autograft of ovarian cortex fragments. Candidates are identified from an observational prospective cohort (called the Prospective Cohort of Patients Candidates for Ovarian Tissue Autograft [PERIDATOR]) of patients who have undergone OTC. Enrollment in the study is initiated at the patient’s request and must be validated by the center’s multidisciplinary team and by the study steering committee. The DATOR study begins with a total medical checkup. Ovarian tissue qualification and residual disease detection, if required, are performed.

Results
The study is ongoing. Currently, 38 patients have provided informed consent and have been entered into the DATOR study. Graft has been performed for 34 of these patients. An interim analysis was conducted on the first 25 patients for whom the period of at least 1 year posttransplantation was achieved. Out of these 25 patients, 11 women succeeded in becoming pregnant (pregnancy rate=44% [11/25]; delivery rate=40% [10/25]). Among these, 6 women conceived twice, and 1 pregnancy led to a miscarriage.

Conclusions
Our preliminary analysis appears to be coherent with the accumulating body of evidence indicating the potential utility of ovarian tissue autograft for patients with premature ovarian failure. All these elements justify the pursuit of our study.

Trial Registration
ClinicalTrials.gov NCT02846064; https://clinicaltrials.gov/ct2/show/NCT02846064

International Registered Report Identifier (IRRID)
DERR1-10.2196/12944