bluuebunny/crossref_metadata_2025_split huggingface dataset:
Even for the environment, context matters! States, households, and residential energy consumption
Authors: Adua Lazarus , Clark Brett 
Published: April 2019

Abstract
This study adopts a multi-level approach to examine the extent to which state- and household-level factors shape residential energy consumption in the United States, focusing on efficiency improvement and affluence. Analyzing the 2009 Residential Energy Consumption Survey, state-level energy efficiency data from the American Council for an Energy-Efficient Economy (ACEEE), and other sources, we find that state context significantly influences energy consumption at the household level. Households in states scoring high on energy efficiency consume significantly less residential energy than those in states scoring low on the measure. At the household level, the analysis reveals mixed relationships between investment in energy efficiency technologies and residential energy consumption, as some measures of efficiency technology are negatively related to residential energy consumption, others are positively related to it. In regard to affluence, state-level measures do not emerge as significant predictors of residential energy consumption. At the household level, however, affluence drives residential energy consumption, which, in turn, is a significant driver of carbon dioxide emissions. Our study makes an important contribution to the social scientific literature on energy consumption, illuminating distinct relationships at different levels. To the best of our knowledge, this is the first study that simultaneously examines the impacts of factors measured at both the household (micro) and state (meso) levels.
Climate drivers of the terrestrial carbon cycle variability in Europe
Authors: Messori G , Ruiz-Pérez G , Manzoni S , Vico G 
Published: April 2019

Abstract
The terrestrial biosphere is a key component of the global carbon cycle and is heavily influenced by climate. Climate variability can be diagnosed through metrics ranging from individual environmental variables, to collections of variables, to the so-called climate modes of variability. Similarly, the impact of a given climate variation on the terrestrial carbon cycle can be described using several metrics, including vegetation indices, measures of ecosystem respiration and productivity and net biosphere-atmosphere fluxes. The wide range of temporal (from sub-daily to paleoclimatic) and spatial (from local to continental and global) scales involved requires a scale-dependent investigation of the interactions between the carbon cycle and climate. However, a comprehensive picture of the physical links and correlations between climate drivers and carbon cycle metrics at different scales remains elusive, framing the scope of this contribution. Here, we specifically explore how climate variability metrics (from single variables to complex indices) relate to the variability of the carbon cycle at sub-daily to interannual scales (i.e. excluding long-term trends). The focus is on the interactions most relevant to the European terrestrial carbon cycle. We underline the broad areas of agreement and disagreement in the literature, and conclude by outlining some existing knowledge gaps and by proposing avenues for improving our holistic understanding of the role of climate drivers in modulating the terrestrial carbon cycle.
Anderson localization and Brewster anomaly of electromagnetic waves in randomly-stratified anisotropic media
Authors: Kim Kihong , Kim Seulong 
Published: April 2019

Abstract
Anderson localization of p-polarized waves and the Brewster anomaly phenomenon, which is the delocalization of p-polarized waves at a special incident angle, in randomly-stratified anisotropic media are studied theoretically for two different random models. In the first model, the random parts of the transverse and longitudinal components of the dielectric tensor, between which the longitudinal component is the one in the stratification direction, are assumed to be uncorrelated, while, in the second model, they are proportional to each other. We calculate the localization length in a precise way using the invariant imbedding method. From analytical considerations, we provide an interpretation of the Brewster anomaly as a phenomenon arising when the wave impedance is effectively uniform. Similarly, the ordinary Brewster effect is interpreted as an impedance matching phenomenon. We derive the existence condition for the Brewster anomaly and concise analytical expressions for the localization length, which are accurate in the weak disorder regime. We find that the Brewster anomaly can arise only when disorder is sufficiently weak and only in the second model with a positive ratio of the random parts. The incident angle at which the anomaly occurs depends sensitively on the ratio of the random parts and the average values of the tensor components. In the cases where the critical angle of total reflection exists, the angle at which the anomaly occurs can be either bigger or smaller than the critical angle. When the transverse and longitudinal components are uncorrelated, localization is dominated by the the transverse component at small incident angles. When only the longitudinal component is random, the localization length diverges as θ
−4 as the incident angle θ goes to zero and is also argued to diverge for all θ in the strong disorder limit.
Spatial distribution of thermoelectric voltages in a Hall-bar shaped two-dimensional electron system under a magnetic field
Authors: Endo Akira , Fujita Kazuhiro , Katsumoto Shingo , Iye Yasuhiro 
Published: April 2019

Abstract
We have investigated the spatial distribution of the electron temperature generated in a two-dimensional electron system (2DES) subjected to a perpendicular magnetic field. We measure thermoelectric voltages between Ohmic contacts located at the end of the voltage-probe arms of a Hall bar fabricated from a GaAs/AlGaAs 2DES wafer, immersed in the mixing chamber of a dilution refrigerator held at 20 mK. Magneto-oscillations due to the Landau quantization are examined for the thermoelectric voltages between the contact pairs straddling the main bar (arrangement to measure the transverse component V

yx
), and between the pairs located along the same side of the main bar (arrangement for the longitudinal component V

xx
). For the former arrangement, the oscillation amplitude diminishes with the distance from the heater. For the latter arrangement, the pair on one side exhibits much larger amplitude than the pair on the opposite side, and the relation becomes reversed by inverting the magnetic field. The behaviours of the oscillation amplitude are qualitatively explained by the spatial distribution of the electron temperature numerically calculated taking into consideration the thermal diffusion into the voltage contacts and the electron-phonon interaction. For both arrangements, the oscillations are shown to derive predominantly from the transverse (Nernst) component, S

yx
, of the thermopower tensor. The calculation also reveals that the voltage probes, introducing only minor disturbance at zero magnetic field, substantially reduce the temperature once a magnetic field is applied, and the thermoelectric voltages generated at the voltage arms account for a significant part of the measured voltages.
Bio-responsive smart polymers and biomedical applications
Authors: Zhang Jieyu , Jiang Xian , Wen Xiang , Xu Qian , Zeng Hao , Zhao Yuxing , Liu Min , Wang Zuyong , Hu Xuefeng , Wang Yunbing 
Published: April 2019

Abstract
Bio-responsive polymers are the foundation for the construction of the smart systems that exhibit designed biomedical functions after receiving specific stimuli such as biological signals and pathological abnormalities. These stimulus-responsive systems have shown great promise of developing novel products in precision medicine, and relevant research has grown intensively in recent years. This review aims to outline the basic knowledge and recent progress in the advanced bio-responsive systems as well as the major challenges. The current bio-responsive systems mainly rely on physical, chemical and biological cues, and this review focuses on the strategies of molecular design for the incorporation of appropriate responsive building blocks. The potential applications, including controlled drug delivery, diagnostics and tissue regeneration, are introduced and promising research directions that benefit the medical translation and commercialization are also discussed.
ProSampler: an ultrafast and accurate motif finder in large ChIP-seq datasets for combinatory motif discovery
Authors: Li Yang , Ni Pengyu , Zhang Shaoqiang , Li Guojun , Su Zhengchang 
Published: April 2019

Abstract

Motivation
The availability of numerous ChIP-seq datasets for transcription factors (TF) has provided an unprecedented opportunity to identify all TF binding sites in genomes. However, the progress has been hindered by the lack of a highly efficient and accurate tool to find not only the target motifs, but also cooperative motifs in very big datasets.

Results
We herein present an ultrafast and accurate motif-finding algorithm, ProSampler, based on a novel numeration method and Gibbs sampler. ProSampler runs orders of magnitude faster than the fastest existing tools while often more accurately identifying motifs of both the target TFs and cooperators. Thus, ProSampler can greatly facilitate the efforts to identify the entire cis-regulatory code in genomes.

Availability and implementation
Source code and binaries are freely available for download at https://github.com/zhengchangsulab/prosampler. It was implemented in C++ and supported on Linux, macOS and MS Windows platforms.

Supplementary information
Supplementary materials are available at Bioinformatics online.
Adaptive boosting-based computational model for predicting potential miRNA-disease associations
Authors: Zhao Yan , Chen Xing , Yin Jun 
Published: April 2019

Abstract

Motivation
Recent studies have shown that microRNAs (miRNAs) play a critical part in several biological processes and dysregulation of miRNAs is related with numerous complex human diseases. Thus, in-depth research of miRNAs and their association with human diseases can help us to solve many problems.

Results
Due to the high cost of traditional experimental methods, revealing disease-related miRNAs through computational models is a more economical and efficient way. Considering the disadvantages of previous models, in this paper, we developed adaptive boosting for miRNA-disease association prediction (ABMDA) to predict potential associations between diseases and miRNAs. We balanced the positive and negative samples by performing random sampling based on k-means clustering on negative samples, whose process was quick and easy, and our model had higher efficiency and scalability for large datasets than previous methods. As a boosting technology, ABMDA was able to improve the accuracy of given learning algorithm by integrating weak classifiers that could score samples to form a strong classifier based on corresponding weights. Here, we used decision tree as our weak classifier. As a result, the area under the curve (AUC) of global and local leave-one-out cross validation reached 0.9170 and 0.8220, respectively. What is more, the mean and the standard deviation of AUCs achieved 0.9023 and 0.0016, respectively in 5-fold cross validation. Besides, in the case studies of three important human cancers, 49, 50 and 50 out of the top 50 predicted miRNAs for colon neoplasms, hepatocellular carcinoma and breast neoplasms were confirmed by the databases and experimental literatures.

Availability and implementation
The code and dataset of ABMDA are freely available at https://github.com/githubcode007/ABMDA.

Supplementary information
Supplementary data are available at Bioinformatics online.
The Challenges of Writing Opinion Pieces in Social Work: A National Online Survey of Swedish Social Workers’ Experiences of Influencing Public Opinion
Authors: Lundälv Jörgen 
Published: April 2019

Abstract
Social workers have an important role to play and a voice to make heard in the public debate. They can make a difference both by working in preventive social work and by taking part in the shaping of public opinion. Being visible and active in the public debate about social work and social policy is a matter of democracy and participation, and provides many opportunities for social workers to explain different welfare terms, forms of support and new treatment methods. This article investigates the extent to which Swedish social workers make themselves visible in the public debate by writing opinion pieces in newspapers and social work journals. Publishing opinion pieces is only one alternative social workers have for contributing to public debate in society. A total of 1,583 social workers responded to an electronic online survey covering their experiences of active participation in the public opinion. The results show that only a limited proportion of these social workers participated in the public debate. Amongst those who had written opinion pieces, the emphasis was above all on the social workers’ own work environment and working conditions. Some of the survey participants had experienced disapproval, disparagement and threats directed at them.
Elevated Cerebrospinal Fluid Tau Protein Concentrations on Admission Are Associated With Long-term Neurologic and Cognitive Impairment in Ugandan Children With Cerebral Malaria
Authors: Datta Dibyadyuti , Conroy Andrea L , Castelluccio Peter F , Ssenkusu John M , Park Gregory S , Opoka Robert O , Bangirana Paul , Idro Richard , Saykin Andrew J , John Chandy C 
Published: April 2019

Abstract

Background
Elevated concentrations of cerebrospinal fluid (CSF) tau, a marker of axonal injury, have been associated with coma in severe malaria (cerebral malaria [CM]). However, it is unknown whether axonal injury is related to long-term neurologic deficits and cognitive impairment in children with CM.

Methods
Admission CSF tau concentrations were measured in 145 Ugandan children with CM and compared to clinical and laboratory factors and acute and chronic neurologic and cognitive outcomes.

Results
Elevated CSF tau concentrations were associated with younger age, increased disease severity (lower glucose and hemoglobin concentrations, malaria retinopathy, acute kidney injury, and prolonged coma duration, all P &lt; .05), and an increased CSF:plasma albumin ratio, a marker of blood–brain barrier breakdown (P &lt; .001). Admission CSF tau concentrations were associated with the presence of neurologic deficits at hospital discharge, and at 6, 12, and 24 months postdischarge (all P ≤ .02). After adjustment for potential confounding factors, elevated log10-transformed CSF tau concentrations correlated with worse cognitive outcome z scores over 2-year follow-up for associative memory (β coefficient, –0.31 [95% confidence interval [CI], –.53 to –.10]) in children &lt;5 years of age, and for overall cognition (–0.69 [95% CI, –1.19 to –.21]), attention (–0.78 [95% CI, –1.34 to –.23]), and working memory (–1.0 [95% CI, –1.68 to –.31]) in children ≥5 years of age (all P &lt; .006).

Conclusions
Acute axonal injury in children with CM is associated with long-term neurologic deficits and cognitive impairment. CSF tau concentrations at the time of the CM episode may identify children at high risk of long-term neurocognitive impairment.
A Review of the Ecology and Management of Black Turpentine Beetle (Coleoptera: Curculionidae)
Authors: Munro Holly L , Sullivan Brian T , Villari Caterina , Gandhi Kamal J K 
Published: April 2019

AbstractThe black turpentine beetle, Dendroctonus terebrans Olivier is the largest pine-infesting bark beetle native to the southern and eastern United States. It generally reproduces in fresh stumps and bases of trees weakened or killed by other biotic or abiotic agents, although it can also infest and sometimes kills apparently healthy trees. Its numbers can build when large amounts of host material become available (typically through a disturbance), and black turpentine beetle-caused mortality at a local scale can become considerable. Here, we provide a complete review of the literature on this species, including its taxonomy, host, life history, chemical ecology, arthropod and microbial associates, and management options. We also provide original data on numbers of instars, acoustic signals, and pheromone chirality in this species. Our survey of the existing literature revealed that key biological characteristics of black turpentine beetles are known, but interactions with closely associated organisms, economic and ecological impacts, and improvements to monitoring and management practices have been only partially investigated.
Sex-Related Differences in Brain Volumes and Cerebral Blood Flow Among Overweight and Obese Adults With Type 2 Diabetes: Exploratory Analyses From the Action for Health in Diabetes Brain Magnetic Resonance Imaging Study
Authors: Espeland Mark A , Hayden Kathleen M , Lockhart Samuel N , Yassine Hussein N , Hoscheidt Siobhan , Yasar Sevil , Luchsinger Jose A , Neiberg Rebecca H , Diaz Brinton Roberta , Carmichael Owen 
Published: April 2019

Abstract

Background
Sex may be an important modifier of brain health in response to risk factors. We compared brain structure and function of older overweight and obese women and men with type 2 diabetes mellitus.

Methods
Cross-sectional cognitive assessments and magnetic resonance images were obtained in 224 women and 95 men (mean age 69 years) with histories of type 2 diabetes mellitus and overweight or obesity. Prior to magnetic resonance images, participants had completed an average of 10 years of random assignment to either multidomain intervention targeting weight loss or a control condition of diabetes support and education. Total (summed gray and white) matter volumes, white matter hyperintensity volumes, and cerebral blood flow across five brain regions of interest were analyzed using mixed-effects models.

Results
After covariate adjustment, women, compared with men, averaged 10.9 [95% confidence interval 3.3, 18.5; ≈1%] cc greater summed region of interest volumes and 1.39 [0.00002, 2.78; ≈54%] cc greater summed white matter hyperintensity volumes. Sex differences could not be attributed to risk factor profiles or intervention response. Their magnitude did not vary significantly with respect to age, body mass index, intervention assignment, or APOE-ε4 genotype. Sex differences in brain magnetic resonance images outcomes did not account for the better levels of cognitive functioning in women than men.

Conclusions
In a large cohort of older overweight or obese adults with type 2 diabetes mellitus, differences in brain volumes and white matter disease were apparent between women and men, but these did not account for a lower prevalence of cognitive impairment in women compared with men in this cohort.

Trial registration
NCT00017953.
Co-production of a pictorial recovery tool for people with psycho-social disability informed by a participatory action research approach—a qualitative study set in India
Authors: Mathias Kaaren , Pillai Pooja , Gaitonde Rakhal , Shelly Kakul , Jain Sumeet 
Published: April 2019

AbstractMental health problems are recognized as a leading cause of disability and have seen increased allocations of resources and services globally. There is a growing call for solutions supporting global mental health and recovery to be locally relevant and built on the knowledge and skills of people with mental health problems, particularly in low-income countries. Set in Dehradun district, North India, this study aimed to describe first, the process of co-production of a visual tool to support recovery for people affected by psycho-social disability; second, the key outputs developed and third, critical reflection on the process and outputs. The developmental process consisted of participatory action research and qualitative methods conducted by a team of action researchers and an experts by experience (EBE) group of community members. The team generated eight domains for recovery under three meta-domains of normalcy, belonging and contributing and the ensuing recovery tool developed pictures of activities for each domain. Challenges to using a participatory and emancipatory process were addressed by working with a mentor experienced in participatory methods, and by allocating time to concurrent critical reflection on power relationships. Findings underline the important contribution of an EBE group demonstrating their sophisticated and locally valid constructions of recovery and the need for an honest and critically reflective process in all co-productive initiatives. This study generated local conversations around recovery that helped knowledge flow from bottom-to-top and proposes that the grass-root experiences of participants in a disadvantaged environment are needed for meaningful social and health policy responses.
Real-time video kinematic evaluation of the in situ beating right ventricle after pulmonary valve replacement in patients with tetralogy of Fallot: a pilot study
Authors: Rozzi Giacomo , Lo Muzio Francesco P , Sandrini Camilla , Rossi Stefano , Fassina Lorenzo , Faggian Giuseppe , Miragoli Michele , Luciani Giovanni Battista 
Published: April 2019

Abstract

OBJECTIVES
The timing for pulmonary valve replacement (PVR) after tetralogy of Fallot repair is controversial, due to limitations in estimating right ventricular dysfunction and recovery. Intraoperative imaging could add prognostic information, but transoesophageal echocardiography is unsuitable for exploring right heart function. Right ventricular function after PVR was investigated in real time using a novel video-based contactless kinematic evaluation technology (Vi.Ki.E.), which calculates cardiac fatigue and energy consumption.

METHODS
Six consecutive patients undergoing PVR at 13.8 ± 2.6 years (range 6.9–19.8) after the repair of tetralogy of Fallot were enrolled. Mean right ventricular end-diastolic and end-systolic volume at magnetic resonance imaging were 115.6 ± 16.2 ml/m2 and 61.5 ± 14.6 ml/m2, respectively. Vi.Ki.E. uses a fast-resolution camera placed 45 cm above the open chest, recording cardiac kinematics before and after PVR. An algorithm defines cardiac parameters, such as energy, fatigue, maximum contraction velocity and tissue displacement.

RESULTS
There were no perioperative complications, with patients discharged in satisfactory clinical conditions after 7 ± 2 days (range 5–9). Vi.Ki.E. parameters describing right ventricular dysfunction decreased significantly after surgery: energy consumption by 45% [271 125 ± 9422 (mm/s)2 vs 149 202 ± 11 980 (mm/s)2, P = 0.0001], cardiac fatigue by 12% (292 671 ± 29 369 mm/s2 vs 258 755 ± 42 750 mm/s2, P = 0.01), contraction velocity by 54% (3412 ± 749 mm/s vs 1579 ± 400 mm/s, P = 0.0007) and displacement by 23% (27 ± 4 mm vs 21 ± 4 mm, P = 0.01). Patients undergoing PVR at lower end-diastolic volumes, had greater functional recovery of Vi.Ki.E. parameters.

CONCLUSIONS
Intraoperative Vi.Ki.E shows immediate recovery of right ventricular mechanics after PVR with less cardiac fatigue and energy consumption, providing novel insights that may have a prognostic relevance for functional recovery.