bluuebunny/crossref_metadata_2025_split huggingface dataset:
Schaár Erzsébet ifjúkora és korai szobrászművészete (1908-1931)
Authors: Konkoly Ágnes 
Published: November 2024

The present paper is a subchapter of my doctoral dissertation titled The Oeuvre of Sculptor Erzsébet Schaár (1908– 1975). The paper discussing a period of her life’s path sofar only tangentially touched on by special literature divides into three parts: the first is concerned with the artist’s family background, childhood and adolescence, the second with the initial phase of the career, the academy years, and the third looks at works created in the 1920s and the early 1930s, as well as exhibitions of that period.Schaár was a veritable “child prodigy”. She began her studies as Zsigmond Kisfaludi Stróbl’s private pupil at the age of sixteen and a year later, in 1925 she was admitted to the Royal Academy of Art where her tutor was again Kisfaludi Stróbl. She debuted with her works publicly in 1926, first of all in exhibitions of the Szinyei Society and the KÚT (=new society of artists). Though several of her that-time works got lost or are latent, an approximately authentic overview of her art in that period can be had from exhibition catalogues, receptions, materials in archives and private collections – first of all the Vilt estate in the King St Stephen Museum in Székesfehérvár and the mostly unprocessed written and photography documents, correspondence in the Schaár estate, as well as from recollections by her contemporaries, first of all Tibor Vilt. A few nudes are known from this period, but her early artistic activity centred on portrait sculpture. This is also the clew along which the phases Schar’s artistic development, the modifications of her style, the influences exerted on her can be demonstrated from the earliest known portraits of her mother to the series of children’s portraits in the late 1920s, early 1930s. The studied period is characterized by a search of her own idiosyncratic style: in the 1920s she created both realistic portraits and works displaying features of art deco and cubism, she was interested in modelling with simple forms, experimented with facial casts – a procedure that returned in later phases of the oeuvre.In sum, the earliest period of Schaár’s sculptural activity displays such singularly powerful idea of plasticity and creative outlook that compare with the later phases of the oeuvre in talent and quality, but with the help of which posterity can discern the trends that were to unfold in full later. Studying this early period may contribute to a more profound understanding and comprehensive interpretation of the entire oeuvre.
Roundtable Discussion: Policy, Data and the UK's Hidden Screen Industries
Authors: Caston Emily 
Published: November 2024

On 8th July 2024, industry leaders Steve Davies and Steve Garvey met at the British Film Institute (BFI) to discuss research and policy issues with the PI and Co-I of the AHRC Hidden Screen Industries network (Emily Caston and Patrick Russell), along with Ian Cade of the BFI’s Research and Statistics Unit. Topics covered included tax reliefs, screen skills, diversity and inclusion, the lack of research on advertising screen production and branded film, and priorities for future research. A selection of excerpts of the key points arising in the discussion are presented in this final contribution to the Special Dossier on Hidden Screen Industries.
Economic analysis of implementing Systemic Coronary Risk Estimation (SCORE2) scale and long-term consequences
Authors: Kurilovich E. O. , Nikitina A. V. , Sorokovikov I. V. 
Published: November 2024

Objective: to assess the demand for pharmacotherapy in risk groups on adverse cardiovascular (CV) events identified during prophylactic medical examination of the adult population according to the SCORE2 (Systemic Coronary Risk Estimation) scale, which is being introduced into clinical practice.Material and methods. To analyze the economic consequences of including diagnostic examinations to assess the risk by SCORE and SCORE2 scales, a Markov model was developed, which described the course of lipid metabolism disorders in adult patients aged 40 to 69 years without concomitant diseases identified during prophylactic medical examination. The model cycle was 2 months (the average waiting time for response to therapy); the modeling horizon was 3 years; the calculated values were estimated for the period 2024–2026. The economic analysis of long-term consequences involved calculating the cost of pharmacotherapy and the costs associated with CV events at outpatient and inpatient stages of medical care. The costs of drug therapy were determined based on dosage regimens presented in instructions for medical use in Russia, and clinical guidelines.Results. According to the modeling results, in the period 2024–2026, the administration of pharmacotherapy to reduce the risks of CV events will enable to achieve 23,224 potentially saved lives through exclusively government funding or 23,605 through mixed sources of funding (government and citizens’ own funds). The cost of the analyzed pharmacotherapy upon the introduction of the SCORE2 scale will be from 50.18 billion rubles (with government funding) to 318.14 billion rubles. Concurrently, pharmacocorrection will provide a reduction in the costs of inpatient treatment and outpatient medical services to 4.1 billion rubles due to the achieving of intended low-density lipoprotein level, and 1.6 billion rubles due to the achieving of intended triglyceride levels.Conclusion. Using new SCORE2 scale may lead to changes in the practice of prescribing lipid-lowering prophylaxis of CV diseases, as well as to a sharp increase in the number of patients who may require earlier prescription of pharmacotherapy to prevent CV events.
In a fully dealcoholised Chardonnay wine, sugar is a key driver of liking for young consumers
Authors: Geffroy Olivier , Podworny Maeva , Brian Laura , Gosset Marianne , Peter Magali , Cheriet Foued 
Published: November 2024

Alcohol-free wines are generally sweetened with around 40 g/L of added sugar to counterbalance sourness, which can be perceived as being excessive in such beverages. For young consumers who would consume alcohol-free products for health purposes, high levels of sugar could be an obstacle. The aim of this work was to investigate this target consumer’s appreciation of fully dealcoholised Chardonnay wines containing different levels of added sugar (0, 5, 10, 20 and 40 g/L). The results showed that liking significantly increased with sugar content, and that acceptability was only achieved in the sample containing 40 g/L of added sugar, with a liking score of between 5 and 6 on a 9-point scale. Liking scores were not affected by gender, information provided to panellists (specifically that they were evaluating alcohol-free wines), and level of wine knowledge. Those who gave the highest scores were occasional wine drinkers and daily soft drink consumers. Conversely, non-wine consumers and non-soft-drink drinkers gave lower liking scores. Though these insights need to be confirmed on more samples of fully dealcoholised wine, they can assist winemakers in developing alcohol-free products and in targeting the right young consumers.
Radiographic Outcome Following Treatment of Residual Hip Dysplasia with Pemberton Versus Salter Osteotomy
Authors: Sucato Daniel J. , Brabham Case E. , De La Rocha Adriana , Podeszwa David A. , Karol Lori A. 
Published: November 2024

Background:
Salter osteotomy (SO) and Pemberton acetabuloplasty (PA) are procedures to treat skeletally immature patients with developmental dysplasia of the hip (DDH). The purpose of this study was to compare the radiographic results and rate of residual dysplasia (RD) after treatment with SO and with PA.

Methods:
This was a retrospective analysis of pediatric patients treated with either SO or PA for DDH between 1980 and 2013 who were skeletally mature at the time of follow-up. The preoperative and postoperative acetabular index (AI) and postoperative lateral center-edge angle (LCEA) and anterior center-edge angle (ACEA) were collected. RD was defined as an LCEA or ACEA of <20° or an acetabular inclination (AIn) of >15° at skeletal maturity. Continuous variables were compared between treatment groups with 2-sample t tests, and categorical variables were compared using chi-square tests. Multivariable analysis was used to identify risk factors for RD with p < 0.05.

Results:
The study included 113 hips in 102 patients with a mean follow-up of 10.5 years. The SO group had 73 hips treated at a mean patient age of 5.4 years, and the PA group had 40 hips treated at a mean age of 5.3 years. The preoperative AI did not differ between the treatment groups (32.2° versus 31.3°, p = 0.658), nor did the immediate postoperative AI (20.0° versus 20.2°, p = 0.459). At the time of final follow-up, the SO group had a significantly smaller AIn (8.6° versus 13.2°, p = 0.001), a trend toward a greater LCEA (26.2° versus 21.6°, p = 0.056), and a similar ACEA (24.1° versus 26.1°, p = 0.808). By the abovementioned definition, 36 hips (31.9%) had evidence of RD, with a lower rate in the SO group (26.0% versus 42.5%, p = 0.07). Patients who had a positive family history of hip dysplasia were more likely to have RD (odds ratio = 4.311, 95% confidence interval = 1.125 to 16.528).

Conclusions:
Patients with RD could be effectively treated with either SO or PA, with overall good radiographic outcomes. However, SO achieved a better AI and may thus yield better long-term health of the affected hip.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Endoscopic Treatment of Proximal Vastus Lateralis Myo-Aponeurosis Rupture in a Professional Skier
Authors: Bonin Nicolas , Ayeni Olufemi R. 
Published: November 2024

Case:
We present the case of a 33-year-old World Cup giant slalom skier treated by endoscopically assisted proximal vastus lateralis (VL) release for persistent lateral thigh pain, due to a VL proximal myo-aponeurosis rupture. At the completion of rehabilitation, he was able to return to Olympic-level competition following surgery and was still symptom free at the 3-year follow-up.

Conclusion:
The unusual location of this injury and the symptoms and physical examination are of interest. The endoscopic release of the VL proximal insertion allowed a rapid and lasting result with a return to competitive skiing at an elite level.
Guided Growth for Correction of Elevated Tibial Posterior Slope in Pediatric ACL Deficiency
Authors: Gaudiani Michael A. , Cooper Trent , Drummond Angela , Hansen Logan M. , Tompkins Marc A. 
Published: November 2024

Case:
Fourteen-year-old boy, history of autism presented with bilateral knee instability. Imaging revealed bilateral anterior cruciate ligament (ACL) insufficiency, 20° of posterior tibial slope (PTS) on the right and 18° on the left. A guided growth technique using anterior placed tension band plates was used to correct the PTS. At 22 months, the PTS corrected to 5.5° on the right and 6° on the left. The patient's knee stability improved, and he resumed activities at 30 months.

Conclusion:
Pediatric ACL insufficiency in the setting of elevated PTS can be successfully corrected with a guided growth technique.
Single-electrode gas sensors based on the composition of indium oxide, aluminum oxide and platinum
Authors: Haiduk Yulyan , Gulayeva Natalya , Podbolotov Kirill , Usenka Alexandra , Pankov Vladimir 
Published: November 2024

Abstract

In2O3/Pt and In2O3/Al2O3/Pt single-electrode gas sensors were manufactured (aluminum oxide was taken in an amount of 8.0 %wt., platinum was taken in an amount of 0.8 %wt and 1.3 %wt. The addition of platinum led to an increase in the response to methane, carbon monoxide and nitrogen dioxide. The addition of aluminum oxide allows you to adjust the resistance of the sensors, it also increases the short-term stability of the sensors. The structure of the composition was studied using powder diffractometry (XRD), infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Additions of aluminum oxide and platinum reduce the size of indium oxide crystallites and increase its specific surface area. Compared to In2O3/Pt sensors, In2O3/Al2O3/Pt sensors have higher selectivity to methane due to reduced sensitivity to carbon monoxide. The In2O3/Al2O3/Pt composite structure and the composition of its properties allow one to apply it for the creation of highly effective sensing elements for semiconductor gas sensors.
Impact of Sodium Chloride Stress on Mung Bean Cultivars in Winter and Summer Seasons: Mitigation Strategies Employing Bacillus Pseudomycoides Inoculum
Authors: Bilal Bushra , Siddiq Zafar , Iftikhar Tehreema , Hayyat Muhammad Umar Umar , Ghaffar Rabia 
Published: November 2024

Abstract

Salt stress poses a significant threat to global agriculture, affecting crop growth and productivity. This study investigated the impact of sodium chloride stress on different mung bean (Vigna radiata) cultivars in both winter and summer seasons and explored potential mitigation strategies employing Bacillus pseudomycoides inoculum. The experiment was conducted in controlled environments during winter and summer seasons, exposing different mung bean cultivars to varying NaCl concentrations (3–15 dSm− 1). Plant growth, yield, physiological attributes, ion uptake and nutrient (protein, carbohydrate, soluble sugar) contents in different plant parts were assessed. Bacillus pseudomycoides inoculum proved highly significant in mitigating the negative effects of salt stress. Results indicated a notable reduction in growth, yield, physiological parameters, chlorophyll content, ion uptake (less Na+ and more K+ ion) and nutrient contents in mung bean plants exposed to elevated NaCl concentrations, with winter crops exhibiting more sensitivity compared to their summer counterparts. However, the introduction of B. pseudomycoides imposed a significant mitigation effect, as reflected in improved plant growth, yield attributes, physiological parameters, ion uptake and nutrient contents. The findings underlined the differential responses of winter and summer crops of mung bean to NaCl stress and emphasized the potential of salt-tolerant bacteria as a sustainable solution for reducing salinity-induced damages. This research contributes valuable insights into developing resilient agricultural practices capable of mitigating the adverse effects of salt stress on mung bean crops in different seasons, thereby enhancing food security in regions susceptible to soil salinization.
A Comprehensive Study of Z-DNA Density and Its Evolutionary Implications in Birds
Authors: Wang Yu-Ren , Chang Shao-Ming , Chen Hsiao-Chien , Lee Lo-Tung , Tsai Dien-Yu , Lee Shih-Da , Lan Chung-Yu , Chang Chuang-Rung , Chen Chih-Feng , Ng Chen Siang 
Published: November 2024

Abstract

Background
Z-DNA, a left-handed helical form of DNA, plays a significant role in genomic stability and gene regulation. Its formation, associated with high GC content and repetitive sequences, is linked to genomic instability, potentially leading to large-scale deletions and contributing to phenotypic diversity and evolutionary adaptation.
Results
In this study, we analyzed the density of Z-DNA-prone motifs in the promoter regions of 154 avian genomes using the non-B DNA Motif Search Tool (nBMST). Our findings indicate a higher prevalence of Z-DNA motifs in promoter regions across all avian species compared to other genomic regions. A negative correlation was observed between Z-DNA density and developmental time in birds, suggesting that species with shorter developmental periods tend to have higher Z-DNA densities. This relationship implies that Z-DNA may influence the timing and regulation of development in avian species. Furthermore, Z-DNA density showed associations with traits such as body mass, egg mass, and genome size, highlighting the complex interactions between genome architecture and phenotypic characteristics. Gene Ontology (GO) analysis revealed that Z-DNA motifs are enriched in genes involved in nucleic acid binding, kinase activity, and translation regulation, suggesting a role in fine-tuning gene expression essential for cellular functions and responses to environmental changes. Additionally, the potential of Z-DNA to drive genomic instability and facilitate adaptive evolution underscores its importance in shaping phenotypic diversity.
Conclusions
This study emphasizes the role of Z-DNA as a dynamic genomic element contributing to gene regulation, genomic stability, and phenotypic diversity in avian species. Future research should experimentally validate these associations and explore the molecular mechanisms by which Z-DNA influences avian biology.
Changes in mitochondrial thymidine metabolism and mtDNA copy number during induced pluripotency
Authors: Lee Man Ryul , Kim Hyun Kyu , Song Yena , Kye Minji , Yu Byeongho , Choi Hyung Kyu , Moon Sung-Hwan 
Published: November 2024

Abstract

Reprogramming somatic cells into human induced pluripotent stem cells entails profound intracellular changes, including modifications in mitochondrial metabolism and a decrease in the mitochondrial DNA copy number. However, the mechanisms underlying this decline in mitochondrial DNA copy number during reprogramming remain unclear. In this study, we aimed to elucidate these underlying mechanisms. Through meta-analysis of numerous RNA sequencing datasets, we identified the genes responsible for the reduction in mitochondrial DNA. We investigated the functions of these identified genes and examined their regulatory mechanisms. Particularly, the thymidine kinase 2 (TK2) gene, required for mitochondrial DNA synthesis and found in the mitochondria, exhibits diminished expression in human pluripotent stem cells compared with that in somatic cells. TK2 was substantially downregulated during reprogramming and markedly upregulated during differentiation. Collectively, the reduction in TK2 levels influences a decrease in mitochondrial DNA copy number and participates in shaping the metabolic characteristics of human pluripotent stem cells. However, contrary to our expectations, treatment with a TK2 inhibitor impaired somatic cell reprogramming. These results suggest that reduced TK2 expression may result from metabolic conversion during somatic cell reprogramming.
Body Maps of Sound Pitch and relevant individual differences in Alexithymic trait and Depressive state
Authors: Daikoku Tatsuya , Horii Takato , Yamawaki Shigeto 
Published: November 2024

Abstract

Sound perception extends beyond the boundaries of auditory sensation, encompassing an engagement with the human body. In this study, we examined the relationship between our perception of sound pitch and our bodily sensations, while also exploring the role of emotions in shaping this intriguing cross-modal correspondence. We also compared the topography of pitch-triggered body sensations between depressive and non-depressive groups, and between alexithymic, and non-alexithymic groups. Further, we examined their associations with anxiety. Our findings reveal that individuals with alexithymic trait and depressive state experience a less localized body sensations in response to sound pitch, accompanied by heightened feelings of anxiety and negative emotions. These findings imply that diffuse bodily sensations in response to sound may trigger negative emotions such as anxiety and indicate that monitoring pitch-triggered body sensations could serve as a valuable biomarker for emotional disorders. Our study sheds light on the importance of bodily sensation in response to sounds, a phenomenon that may be mediated by interoception. This research enhances our understanding of the intricate relationship between sound, emotions, and the human body, offering insights for potential interventions in emotional disorders.
Biocarbon nanoadsorbents derived from walnut shell and their excellent adsorption of trinitrotoluene from wastewater
Authors: Shi Xiaofeng , Si Chao , Liu Zhenguo , Dong Yu , Sun Jiaji 
Published: November 2024

Abstract

A new reusable biomass derived adsorbent biocarbon material was prepared by charring ball-milled walnut shell powders under an inert gas atmosphere and treating with sodium hydroxide (NaOH) solution (the formed biochar is named as WS). WS was able to achieve a rapid adsorption of trinitrotoluene (TNT) from waste streams, reaching an equilibrium within 30 min. The maximum adsorption capacity reached 107.0 mg·g-1. The TNT adsorption from waste streams by WS followed the Langmuir isotherm model and the proposed second order kinetic model. The WS prepared in this study was able to achieve an efficient removal of TNT waste streams through the synergistic effect of electrostatic attraction and chemisorption.
Homogeneous and Bioluminescent Biochemical and Cellular Assay for Monitoring cGAMP and Enzymes that Generate and Degrade cGAMP
Authors: Hsiao Kevin , Murray Nathan H. , Mikheil Dareen , Larsen Matthew A. , Wang Hui , Ugo Tim , Goueli Said A. 
Published: November 2024

Abstract

The cyclic GMP-AMP synthase-stimulator of the interferon gene (cGAS-STING) signaling pathway is considered an essential pattern recognition and effector pathway in the natural immune system and is mainly responsible for recognizing DNA molecules present in the cytoplasm and activating downstream signaling pathways to generate type I interferons (IFN-I) and other inflammatory factors. STING, a crucial junction protein in the innate immune system, exerts an essential role in host resistance to external pathogen invasion. The DNA introduced by pathogens or tumors is recognized by the cytoplasmic nucleic acid receptor cGAS, and a second messenger, cGAMP, is generated using intracellular guanosine triphosphate (GTP) and adenosine triphosphate (ATP). Furthermore, cellular and extracellular cGAMP concentrations are also controlled by ENPP1, an enzyme that breaks down cGAMP to AMP and GMP. Therefore, the role of the cGAS-STING signaling pathway has generated great interest in inflammatory and cancer research. To advance our understanding of innate immune system and in particular the STING pathway, we have developed a homogeneous, bioluminescent cGAMP detection assay that is very sensitive and highly selective against other nucleotides, cyclic nucleotides, and dicyclic nucleotides. The assay can be also used to monitor the activity of cGAS and ENPP1 to enable the development of inhibitors of both enzymes which might be used for therapeutic applications.