bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN TINGKAT PENGETAHUAN KOGNITIF DENGAN KEMAUAN MELAKUKAN CARDIOPULMONARY RESUSCITATION (CPR) PADA REMAJA DI SMAN MALANG
Authors: Maulidia Rahmawati , Loura Nining 
Published: August 2019

The action that connects survivors of cardiac arrest is called the Chain of Survival. Chain of Survival. The role of CPR bystander is very important to save cardiac arrest victims, therefore training and knowledge about CPR are being disseminated to ordinary people including in Indonesia. According to a preliminary study obtained by researchers, education about basic life assistance has been taught in several state high schools in Malang, especially in material taught at the Youth Red Cross (PMR). The purpose of this study is to to determine the relationship of cognitive knowledge level with the willingness to perform cardiopulmonary resuscitation (CPR) in adolescents in poor public high schools. Method In this research, This study used a correlational analytic design with a crossectional approach to determine the relationship of cognitive knowledge level with the willingness to perform cardiopulmonary resuscitation (CPR) in adolescents. The study sample consisted of 76 respondents. The sampling technique uses cluster sampling. The inclusion criteria for nurses were as follows: PMR members in Malang State High School who were still active, students who were willing to become respondents. While the exclusion criteria: students who are not present at the time of data collection and experience disability / disability. The independent variable of this study is the level of cognitive knowledge while the dependent variable is the willingness to do. The instrument in this study used a questionnaire CPR. Statistical results using the Chi Square test show that the p value is 0.002 (<0.05). This shows that there is a relationship between the level of cognitive knowledge and the willingness to do CPR in adolescents in Malang Senior High School. The better the cognitive cognitive level of a person, the higher a person's willingness to do CPR. Willingness to do CPR will help in minimizing the incidence of cardiac arrest in the community. Keywords: Cardiopulmonary Resuscitation (CPR), Willingness, Level of Cognitive Knowledge
Entre mutualisation des infrastructures et diversité des usages
Authors: Hubert Matthieu 
Published: August 2019

Cet article étudie quatre plateformes d’un pôle de recherche en micro- et nanotechnologies en les analysant comme des infrastructures. L’observation du travail concret de mise en plateforme témoigne d’une tension entre une logique de mutualisation, indispensable à sa légitimation en tant qu’instrument privilégié par les pouvoirs publics pour financer et structurer la recherche, et une logique de fabrication de modèles d’organisation ad hoc, répondant à la diversité des pratiques expérimentales. L’enquête montre ainsi que, dans certains cas de figure, les acteurs des plateformes privilégient des formes minimales de mutualisation afin de mieux gérer les contradictions de l’organisation en plateforme et conserver des marges de manœuvre dans la mise en œuvre des activités expérimentales.
Influence subie, influence exercée
Authors: Murard Lion 
Published: August 2019

Loin d’en avoir été les parents pauvres, les jeunes États de l’Est européen auront été pour l’Organisation d’hygiène de la SDN de constants remorqueurs, en même temps qu’un point d’appui pour les grandes philanthropies privées, Fondation Rockefeller en tête. Influence subie , les Écoles et Instituts d’hygiène de l’Europe danubienne opèrent sous le magistère de l’Amérique. Influence exercée , les accomplissements de leurs « returned fellows » sortent de l’ombre. Tout engourdi qu’il paraisse, le sous-continent trouve peu à peu sa voix au gré de traductions-naturalisations qui, donnant à ce qui vient de l’extérieur l’apparence d’un produit autochtone, en rendirent les réalisations-phares exportables, et ce jusqu’en Chine. De la police sanitaire à la médecine sociale, l’autre Europe aura ainsi fourni à l’OMS naissante son assiette idéologique : le relèvement des campagnes.
D’une guerre à l’autre
Authors: Colin Lebedev Anna 
Published: August 2019

L’article interroge l’impact de la guerre dans le Donbass sur un groupe spécifique : les vétérans ukrainiens de la guerre soviétique en Afghanistan. Comment un groupe ayant construit sa légitimité sur une expérience armée fait-il face à une nouvelle guerre, plusieurs décennies plus tard ? Après une présentation de l’insertion des vétérans d’Afghanistan dans la société ukrainienne, l’article cherche à répondre à trois questions : les anciens combattants ont-ils une place spécifique dans la guerre dans le Donbass ? La guerre transforme-t-elle le réseau solidaire et structuré des vétérans ? Quelle est la profondeur des clivages sociaux introduits par la guerre ?
Politics in the Tajik Emigrant Community Complex
Authors: Kluczewska Karolina , Korneev Oleg 
Published: August 2019

Cet article retrace les différentes origines, le développement, l’influence et les positions politiques de diverses communautés d’émigrés tadjiks qui ont émergé après l’éclatement de l’Union soviétique, principalement en Russie, mais également au-delà de l’espace post-soviétique. Il montre que des facteurs tels que la date et le mode d’arrivée, la région d’origine, le statut socio-économique dans la société d’accueil, ainsi que les politiques du pays d’accueil et du pays d’origine ont tous une incidence sur les interactions au sein de ces groupes d’émigrés et entre eux, ainsi que sur leurs engagements avec la patrie. L’article porte un regard critique sur l’activisme sociopolitique au sein du complexe de la communauté d’émigrés tadjiks et met en évidence différentes formes et différents niveaux de mobilisation. Il montre également la complexité des réponses apportées par le gouvernement tadjik aux activités des émigrants, fondées sur l’« utilité perçue » de différentes communautés d’émigrés.
L’inéluctable légalisation du cannabis en France ?
Authors: Ben Lakhdar Christian 
Published: August 2019

Alors qu’à l’encontre des traités internationaux, nombre de pays légalisent actuellement le marché du cannabis, la France, quant-à-elle, reste campée sur une politique prohibitionniste fondée sur la loi du 31 décembre 1970. Sous un cadre de changement institutionnel proposé par l’économie néo-institutionnelle, nous supposons cependant que la légalisation du cannabis apparaît être inéluctable en France. Principalement, les arrangements organisationnels qui ont émergé ces dernières années et concurrencé le marché illicite en diminuant le risque et l’incertitude des transactions ne peuvent que disqualifier l’efficacité de la répression policière en plus d’accroitre la violence sur le marché illégal. Couplé à l’agenda politique des actions de réduction des risques de l’usage de drogue ainsi qu’à la qualification du cannabis en tant que médicament, la perception des acteurs évolue graduellement et inévitablement en faveur d’une légalisation de cette substance psychoactive. Et ce d’autant plus que des entrepreneurs de morale de premier plan plaident désormais en faveur de cette réforme.
Low Cellular NAD+ Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes
Authors: Yang Kuan , Lauritzen Knut Husø , Olsen Maria Belland , Dahl Tuva Børresdatter , Ranheim Trine , Ahmed Mohammed Shakil , Attramadal Håvard , Aukrust Pål , Halvorsen Bente , Nyman Tuula Anneli , Sandanger Øystein , Yndestad Arne 
Published: August 2019

Abstract
NAD+ is an essential cofactor in reduction-oxidation metabolism with impact on metabolic and inflammatory diseases. However, data elucidating the effects of NAD+ on the proinflammatory features of human primary monocytes are scarce. In this study, we explored how NAD+ affects TLR4 and NOD-like receptor with a PYD-domain 3 (NLRP3) inflammasome activation, two key innate immune responses. Human primary monocytes were isolated from buffy coats obtained from healthy individuals. Intracellular NAD+ was manipulated by nicotinamide riboside and the NAMPT inhibitor FK866. Cells were primed with LPS with or without subsequent NLRP3 activation with ATP or cholesterol crystals to analyze the effects of NAD+ levels on TLR4-mediated NF-κB activation and NLRP3 activity, respectively. Cytokine release was quantified, and the downstream signal pathway of TLR4 was investigated with Western blot and proteomic analysis. The impact of sirtuin and PARP inhibition was also explored. Our main findings were: 1) elevated NAD+ enhanced IL-1β release in LPS-primed human monocytes exposed to ATP in vitro, 2) both NLRP3-dependent and -independent inflammatory responses in LPS-exposed monocytes were inhibited by NAD+ depletion with FK866, 3) the inhibition was not caused by suppression of sirtuins or PARP1, and 4) phosphorylation of several proteins TLR4 signal pathway was inhibited by FK866-mediated NAD+ depletion, specifically TAK1, IKKβ, IkBα, MEK 1/2, ERK 1/2, and p38. Hence, we suggest a novel mechanism in which NAD+ affects TLR4 signal transduction. Furthermore, our data challenge previous reports of the interaction between NAD+ and inflammation and question the use of nicotinamide riboside in the therapy of inflammatory disorders.
Influenza Vaccination Primes Human Myeloid Cell Cytokine Secretion and NK Cell Function
Authors: Wagstaffe Helen R. , Pickering Harry , Houghton Joanna , Mooney Jason P. , Wolf Asia-Sophia , Prevatt Natalie , Behrens Ron H. , Holland Martin J. , Riley Eleanor M. , Goodier Martin R. 
Published: August 2019

Abstract
Cytokine-induced memory-like (CIML) NK cells generated in response to proinflammatory cytokines in vitro and in vivo can also be generated by vaccination, exhibiting heightened responses to cytokine stimulation months after their initial induction. Our previous study demonstrated that in vitro human NK cell responses to inactivated influenza virus were also indirectly augmented by very low doses of IL-15, which increased induction of myeloid cell–derived cytokine secretion. These findings led us to hypothesize that IL-15 stimulation could reveal a similar effect for active influenza vaccination and influence CIML NK cell effector functions. In this study, 51 healthy adults were vaccinated with seasonal influenza vaccine, and PBMC were collected before and up to 30 d after vaccination. Myeloid and lymphoid cell cytokine secretion was measured after in vitro PBMC restimulation with low-dose IL-15, alone or in combination with inactivated H3N2 virus; the associated NK cell response was assessed by flow cytometry. PBMC collected 30 d postvaccination showed heightened cytokine production in response to IL-15 compared with PBMC collected at baseline; these responses were further enhanced when IL-15 was combined with H3N2. NK cell activation in response to IL-15 alone (CD25) and H3N2 plus IL-15 (CD25 and IFN-γ) was enhanced postvaccination. We also observed proliferation of less-differentiated NK cells with downregulation of cytokine receptors as early as 3 d after vaccination, suggesting cytokine stimulation in vivo. We conclude that vaccination-induced “training” of accessory cells combines with the generation of CIML NK cells to enhance the overall NK cell response postvaccination.
Ezrin is a prognostic biomarker in patients with clear cell metastatic renal cell carcinoma receiving sunitinib
Authors: Cetin Bulent , Gonul Ipek Isik , Gumusay Ozge , Afsar Baris , Bilgetekin Irem , Ozet Ahmet , Uner Aytug 
Published: August 2019

Objective:
Sunitinib is a novel oral multitargeted tyrosine kinase inhibitor with antitumor and antiangiogenic activities. This study evaluates ezrin expression in sunitinib-treated metastatic clear cell renal cell carcinoma (ccRCC) patients and elucidates its role as a possible marker for survival.

Materials and Methods:
The expression of ezrin was measured by immunohistochemistry in 80 patients with ccRCC treated by first-line sunitinib between January 2007 and June 2012. Kaplan–Meier curves and log-rank tests were used for analysis of progression-free survival and overall survival (OS), and a multivariate Cox proportional hazard model was employed to identify factors with an independent effect on the survival.

Results:
In multivariate analysis, liver metastasis (P = 0.018; hazard ratio [HR]: 3.707 (1.257–10.931) and overexpression of ezrin (P = 0.006; HR: 2.993 (1.373–6.523 95% confidence interval) were remained significant factors influencing OS. Overexpression of ezrin in the patients who had progressed in the first 3 months was higher than in the patients who had progressed after 3 months (P = 0.003). The median OS was longer in patients with low levels of ezrin expression (27 months) compared to patients overexpressing ezrin (12 months) (P = 0.001).

Conclusion:
This is the first study in the literature showing that ezrin status is related with prognosis in patients with metastatic ccRCC.
Active surveillance in renal tumors
Authors: Bazan Alfredo Aguilera , Carrion Diego M. , Rivas Juan Gomez , Quesada-Olarte Jose , Quintana Luis M. , Alvarez-Maestro Mario , Martínez-Piñeiro Luis 
Published: August 2019

Context:
Some patients diagnosed with small renal solid masses or complex cystic lesions may benefit from active surveillance (AS) instead of immediate treatment.

Aims:
Report our series of patients undergoing AS for small renal solid and complex cystic lesions, and compare growth rates and outcomes between both types of lesions.

Materials and Methods:
A retrospective review AS database for renal lesions was conducted. From 1995 to 2017, a total of 82 patients with 89 renal lesions were included. We describe our AS protocol, patient and tumor characteristics, comparisons between solid and cystic lesions, and final outcome of patients who underwent delayed intervention (DI).

Statistical Analysis Used:
Categorical and continuous data were analyzed by the Chi-square and the Student's t-test, respectively. The Wilcoxon/Kruskal–Wallis test was used for growth rate comparisons of solid and complex cystic lesions.

Results:
Median age of patients at the beginning of AS was 77-year-old, median size for solid and cystic lesions was 2.3 cm (0.08–3.8) and 2.6 cm (1.2–4.0), respectively. No differences in annual growth rate between solid and complex cystic lesions (0.04 cm [0.00–1.5] and 0.05 cm [0.01–1.7]) were observed at a similar median follow-up of 61 months for both groups (range: 15–182, and 14–254). Five patients with solid lesions underwent DI, 3 for rapid growth (>0.5 cm/year), 1 demanded treatment, and 1 due to hematuria. Adherence to AS protocol was high (94%). No cancer-related deaths or metastatic progression was observed, six patients died of another medical condition, being cardiovascular disease the most frequent cause.

Conclusions:
AS is a reasonable and safe option for the management of small renal masses. No difference was observed in the growth rate between solid and complex cystic lesions during AS. Centers offering AS should present a standardized protocol and give exhaustive information to patients regarding benefits and risks.
Effect of SO2, O2, NO2, and H2O Concentrations on Chemical Reactions and Corrosion of Carbon Steel in Dense Phase CO2
Authors: Morland Bjørn H. , Norby Truls , Tjelta Morten , Svenningsen Gaute 
Published: August 2019

Carbon capture, utilization, and storage is expected to be an important method for reducing CO2emissions to prevent global warming. Several species (impurities) could follow the CO2through the capture plant as carry over. It is expected that nitrogen dioxide (NO2), sulfur dioxide (SO2), oxygen (O2), and water (H2O) can be present as impurities (concentrations at the ppmv level) in the captured CO2. The exact composition will depend on the flue gas type, the CO2capturing process, and multiple other parameters. Some of these impurities are reactive and may cause corrosion in carbon steel pipelines and could therefore be a threat for safe CO2transport. The present study used a novel experimental setup to realistically simulate a CO2transport pipeline system with a controlled and variable concentration of impurities at a total pressure of 10 MPa and a temperature of 25°C. The water concentration was increased and decreased with constant concentration of SO2and O2, to observe and identify possible reactions or threshold levels which could cause corrosion. A similar experiment was conducted with NO2. First, experiments were performed without steel coupons, to observe uncatalyzed reactions, and then with coupons to measure corrosion rates. The first sign of corrosion appeared at 350 ppmv of water with NO2present. At 670 ppmv water with 75 ppmv NO2the overall corrosion rate was about 0.57 mm/y and the main product was iron oxide. The corrosion process for SO2, O2, and water was much slower, and the first sign of corrosion appeared around 1,900 ppmv of water, with about 75 ppmv of SO2and 230 ppmv of O2. The corrosion rate increased some when the water concentration was increased to 2,400 ppmv, but the overall corrosion rate was only 3.6 μm/y and the main product on the surface was iron sulfate.
Addressing Diabetes in Primary Care: Hybrid Effectiveness–Implementation Study of Lifestyle Redesign® Occupational Therapy
Authors: Pyatak Elizabeth , King Maggie , Vigen Cheryl L. P. , Salazar Elia , Diaz Jesus , Schepens Niemiec Stacey L. , Blanchard Jeanine , Jordan Katie , Banerjee Josh , Shukla Jagruti 
Published: August 2019

Abstract
Importance: Primary health care is rapidly developing as an occupational therapy practice area. Yet, to date, little evidence supports occupational therapy’s feasibility and efficacy in primary care settings.
Objective: To report on the implementation and preliminary clinical outcomes of a Lifestyle Redesign® (LR)–occupational therapy (LR–OT) diabetes management intervention in a primary care clinic.
Design: Patients were randomized to be offered LR–OT or to a no-contact comparison group (data not reported). We assessed implementation outcomes using mixed methods.
Setting: Safety-net primary care clinic.
Participants: Clinic providers and staff; English- or Spanish-speaking clinic patients ages 18–75 yr with diabetes and a current hemoglobin A1c (HbA1c) ≥ 9.0%.
Intervention: Eight 1-hr individual sessions of LR–OT focused on diabetes management.
Outcomes and Measures: Clinical and health behavior outcomes were assessed via electronic medical record (EMR) review and self-report surveys of patients receiving LR–OT at initial evaluation and discharge. We assessed implementation outcomes (acceptability, appropriateness, feasibility, fidelity, efficiency, and timeliness) using patient and staff surveys, interviews, focus groups, and observations.
Results: Seventy-three patients were offered LR–OT: 51 completed one or more sessions, and 38 completed the program. Clinical outcomes among program completers indicate beneficial changes in HbA1c, diabetes self-care, and health status. Implementation challenges included a need for patient and staff education, securing adequate workspace, and establishing a referral process. Factors contributing to implementation success included strong buy-in from clinic leadership, colocation, and shared EMR documentation.
Conclusions and Relevance: LR–OT is a feasible approach to enhancing service delivery and clinical outcomes in primary care.
What This Article Adds: This study provides insight into factors that may create challenges or contribute to the success of implementing occupational therapy services within primary health care settings. In addition, this study provides preliminary evidence of occupational therapy’s effectiveness in improving clinical outcomes among ethnically diverse, low-income patients with diabetes in a safety-net primary care setting.
Mana e Substâncias Xamânicas: As Reconfigurações de Poder entre os Siona da Colômbia
Authors: Langdon Esther Jean 
Published: August 2019

Inspirada pela discussão recente de Crépeau e Laugrand sobre mana, examino, entre os indígenas siona, a noção de rau como o conceito central para entender poder xamânico e práticas rituais. Assim, em vez de tratar rau como uma categoria estável do pensamento e de práticas indígenas, exploro esta noção como um conceito fluido e polissêmico que tem sofrido transformações no decorrer de contextos históricos e sociais. Como as discussões recentes sobre mana demonstram, rau é melhor entendido como um fenômeno social cujos usos e significados têm se transfigurado através do tempo e espaço. Rau foi primeiramente notado e traduzido por missionários no século XVII. Minha análise baseia-se em traduções do termo rau encontradas em documentos de missionários franciscanos e capuchinhos, nas traduções dos Siona oferecidas a mim na década de 1970, em diálogo sobre suas narrativas xamânicas, como também em traduções mais recentes oferecidas pelos taitas siona, num contexto de revitalização xamânica iniciado na década de 1990.
Integration of Information and Communication Technologies in Teaching by Female Academic Teaching Staff in the Higher Education Sector in Mauritius
Authors: Baguant Noshmee Devi 
Published: August 2019

Information and Communication Technologies (ICT) is increasingly being used to support the process of academic teaching in the higher education sector. However, it is imperative to understand the causes for minimal utilisation of ICT tools by female academic teaching staff in their teaching process, resulting in gender inequity in technology. The research examined the correlation between ICT integration in the teaching process by female academic teaching staff in the higher education sector in Mauritius and the factors that could improve such integration in line. Futures thinking methodology was used for this study to address policy, strategies and actions to support appropriate futures. It comprised an evaluation of the sources and causes of change to map a probable future and a preferable future. The future thinking methods included signalling, horizon scanning, future wheel analysis, alternate futures framework and determining scenarios. As a result of the research, recommendations were made to assist policy makers and decision makers to develop evidence based policies to address gender inequity in the use of technology in higher education.
Eigen Kracht in de buurt – durven we wel?
Authors: van Diepen Piet 
Published: August 2019

Eigen Kracht within the neighbourhood: should we dare?
In various neighbourhoods in Amsterdam tensions between their inhabitants are felt. Inhabitants are irritated by the behaviour of youths, polluted streets and nuisance from their neighbours. They are incapable or do not dare to address each other about this and to solve their problems by themselves. Instead they look towards the authorities for help, which are dealing with insufficient capacity. As a consequence it is getting harder and harder to address and correct each other. Small problems and conflicts develop into big and complex issues.Amsterdam authorities use various policy tools, pointed at both increasing its own decisiveness and credibility and at mobilizing civilians. Those policies are the Bully-approach, Neighbourhood Safety Teams, Self-protective Neighbourhoods and stimulation of civic initiatives. The reality is stubborn, but also shows bottom-up examples which function succesfully and independently from government approaches and programs. In these examples civic force plays an important role.These examples, knowledge and persons who play key roles can be brought together and are useful in the search for solutions of problems in other situations. This is most effective when civilians attack issues and are integrated with worthy instruments from the authorities. This will gradually enable a reconstruction of the current system and a social reacquisition of neighbourhoods. In this social ‘football ‘ team civilians would be the strikers, backed up by a strong and professional governmental midfield. This article consecutively defines the current problem, regards the governmental instruments, bottom-up initiatives. It ends up with the suggestion for the construction of a good teamplay between policy tools en bottom up initiatives.