bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging trend of vancomycin-resistant enterococcal bacteremia in a university hospital in Northern India – An observational study
Authors: Sarawat Deepika , Varghese Gerlin , Jamwal Ashima , Tejan Nidhi , Patel Sangram , Sahu Chinmoy 
Published: November 2024

Objectives:
Vancomycin Resistant Enterococcus (VRE) species has been increasing and is now of serious concern. The aim of the study was to find the prevalence of VRE bacteremia at our institution. Also, the demographic pattern, associated risk factors, sensitivity pattern and outcomes associated with bacteremia caused by VRE were also estimated.

Materials and Methods:
This observational study was done in the Microbiology department of our institute from April 2022 to June 2023. All patients with blood cultures positive for Enterococcus species for the first time were included in the study. Identification was done using MALDI-Tof MS. Antimicrobial Sensitivity Testing was and interpreted using Clinical and Laboratory Standards Institute (CLSI) 2023 M-100. The demographic details, risk factors, and the clinical outcome of the patients were collected and analyzed.

Statistical Analysis:
All the data were entered in Excel sheets. The univariate analysis was done for the risk factors and outcome of the patients with VRE bacteremia and VSE (Vancomycin Sensitive Enterococcus) bacteremia. 95% confidence interval, Odd’s ratio and p-value was estimated.

Results:
During the study period, 29086 blood culture bottles were received. Of these, 2016 (6.93%) bottles flagged positive. Enterococcus species were isolated from 256 (12.69%) blood cultures. Of the 256 Enterococcus isolates, 45 (17.57%) isolates were Vancomycin resistant. Most common species were Enterococcus faecium (n=42; 93.33%). Most of the patients belonged to the age group 41-60 years (31.11%). Diabetes mellitus and neutropenia were found to be significant risk factors. All the isolates showed 100% resistance to Teicoplanin, Ampicillin, Ampicillin-sulbactam and Levofloxacin. Mortality was significantly higher in patients with VRE bacteremia as compared to patients with Vancomycin Sensitive Enterococcal (VSE) bacteremia.

Conclusion:
Proper implementation of antimicrobial stewardship rules in the hospital is the best way to overcome the increasing trend of resistance.
Surrogate immunohistochemistry markers in adult gliomas – Experience in a tertiary care hospital
Authors: Shrivastava Kanchan , Jain Sunila 
Published: November 2024

Objectives:
The recent World Health Organization classification has recommended the usage of surrogate immunohistochemical markers for molecular classification of gliomas. However, only a few studies have attempted to study the expression of the entire panel of markers. The current study was undertaken to study the association of recognized surrogate immunohistochemical markers (isocitrate dehydrogenase 1 [IDH-1], alpha-thalassemia mental retardation X-linked [ATRX] and p53) in different histological lineages and grades of adult gliomas.

Materials and Methods:
This study was conducted on 118 cases of adult gliomas diagnosed on histopathology over a 2-year duration in a tertiary care hospital. The expression of surrogate immunohistochemistry markers (IDH-1, ATRX, and p53) in these cases was studied.

Statistical analysis:
Descriptive statistical analysis with the Statistical Package for the Social Science system version 17.0.

Results:
The frequency of IDH-1 positivity was significantly higher in oligodendrogliomas (OG: 76.5%; oligoastrocytoma: 100%) versus astrocytoma (AS) (grades 2 and 3: 48.1%). It was also significantly higher in diffuse gliomas (grades 2 and 3) versus glioblastomas (64% vs. 16.9%). Among IDH-mutant diffuse gliomas, ATRX loss was significantly higher in AS versus OGs (84.6% vs. 7.7%). P53 overexpression correlated significantly with histological subtype (AS 2,3: 55.6% vs. OG: 5.9%).

Conclusions:
The surrogate immunohistochemical panel of IDH-1, ATRX, and p53 showed significant association with distinct histopathological subtypes and is helpful in molecular stratification. Cut-offs of ≥ 10% nuclear positivity for p53 and 50% loss of nuclear ATRX expression showed a good correlation.
Уточненная математическая модель теплового воздействия лазерного излучения на тело ограниченных размеров
Authors: А.П. Удалова , А.Д. Цой 
Published: November 2024

В статье представлена уточненная математическая модельтеплового воздействия лазерного излучения на материалы в условиях адиабатических границ тела, основанная на классическом уравнении теплопроводности с граничными условиями первого и второго рода. Для данной модели предложена методика расчета изотермы распространения тепла в ограниченном теле и еереализация в среде PTC MathCAD. Предложенная математическая модель позволяет провести более точный расчет теплового воздействия лазерного излучения на металлы в условиях отсутствия теплообмена с внешней средой (например, в вакууме).
The article presents the refined mathematical model of the thermal effect of laser radiation on materials under conditions of adiabatic solid boundaries, which is based on the classical heat conduction equation with boundary conditions of the first and second kind. For this model, a method for calculating the heat propagation isotherm in a bounded solid and its implementation in the MATHCAD environment is proposed. The proposed mathematical model allows for a more exact calculation of the thermal effect of laser radiation on metals in the absence of heat exchange with the external environment (for example, in a vacuum).
Термические свойства высокоэнергетических композиций на основе TEX
Authors: М.В. Комарова , А.Г. Вакутин , Н.В. Козырев 
Published: November 2024

В статье изложены результаты экспериментальных исследований термических свойств литьевых композиционных систем, содержащих плавкие высокоэнергетические материалы и кристаллическую составляющую. Методами термогравиметрического анализа и дифференциальной сканирующей калориметрии получены термические характеристики составов, включающих 4,10-динитро-2,6,8,12-тетраокса-4,10-диазатетрацикло[5.5.0.05,9.03,11]-додекан и расплавы 2,4-динитротолуола, 2,4- динитразапентана, 2,4,6-тринитротолуола, динитрата диэтанолнитрамина, 3,4-бис(4-фуразанил)фуроксана, этоксиметил-3-нитро-1,2,4-триазола, третбутил-3-нитро-1,2,4-триазола, 1-метил-3-нитро-триазола. Показано отсутствие растворимости 4,10-динитро-2,6,8,12-тетраокса-4,10-диазатетрацикло[5.5.0.05,9.03,11]-додекана в расплавах плавких компонентов; проявление синергизма при нагреве высокоэнергетических композиций. Выяснено, что состав с 1-метил-3-нитро-триазолом наименее чувствителен, а с 2,4,6-тринитротолуолом содержит наибольшее количество тепла.
The article describes experimental studies of the thermal properties of cast composites containing fusible high-energy materials and a crystalline component. The thermal properties of the compositions obtained by thermogravimetry and differential scanning analysis. The compositions contained 4,10-dinitro-2,6,8,12-tetraox-4,10-diazatetracyclo[5.5.0.05,9.03,11]-dodecane and additives: 2,4-dinitrotoluene, 2,4- dinitrazapentane, 2,4,6-trinitrotoluene, diethanolnitramine dinitrate, 3,4-bis(4-furazanyl)furoxane, ethoxymethyl-3-nitro-1,2,4-triazole, tretbutyl-3-nitro-1,2,4-triazole and 1-methyl-3-nitro-triazole. The absence of solubility of 4,10-dinitro-2,6,8,12-tetraox-4,10-diazatetracyclo[5.5.0.05,9.03,11]-dodecane in melts of fusible components was shown. The synergism of the components during heating of the compositions is noted. The composition with 1-methyl-3-nitro-triazole is the least sensitive; with 2,4,6-trinitrotoluene it contains the largest amount of heat.
ДИАМИНОМОЧЕВИННЫЙ КОМПЛЕКС НИКЕЛЯ НА ОСНОВЕ N,N'-динитромочевины
Authors: Д.С. Ильясов 
Published: November 2024

Исследовано взаимодействие N,N'-динитромочевины с гидроксидами Cu2+, Ni2+, Zn2+ и Co2+ в присутствии N,N'-диаминомочевины. Показано, что при смешении водных растворов N,N'-диаминомочевины и Cu2+, Ni2+ солей N,N'-динитромочевины образуются нерастворимые в воде осадки, а с металлами Zn2+ и Co2+ образуются комплексы в водных растворах, структура которых была установлена методом спектрофотометрии. Трудности на стадии выделения из реакционной массы связаны с гигроскопичностью получаемых веществ. Для получения кристаллических продуктов реакцию проводят в концентрированных растворах. Взаимодействием N,N'-динитромочевины с гидроксидом никеля в присутствии диаминомочевины впервые синтезирован катионный комплекс никеля (2+), содержащий в своем составе 3 моля лиганда N,N'-диаминомочевины и аниона N,N'-динитромочевины. Синтезированные вещества были идентифицированы с помощью ЯМР, ИК, УФ спектроскопии и элементного анализа, а также DSC и TGA анализов. Проведенный расчёт брутто состава соответствует Ni2+((O2NN)2C=O)2-((H2NHN)2C=O)3(H2O).
The interaction of N,N'-dinitrourea with Cu2+, Ni2+, Zn2+ and Co2+ hydroxides in the presence of N,N'-diaminourea has been studied. It was shown that when mixing aqueous solutions of N,N'-diaminourea and Cu2+, Ni2+ salts of N,N'-dinitrousurea, water-insoluble precipitates are formed, and with metals Zn2+ and Co2+, complexes are formed, which were determined in aqueous solutions using UV spectrophotometry. Difficulties at the stage of isolation from the reaction mass are associated with the hygroscopicity of the substances obtained. To obtain crystalline products, the reaction is carried out in concentrated solutions. By reacting N,N'-dinitrousurea with nickel hydroxide in the presence of diaminourea, a cationic complex of nickel (2+) was synthesized for the first time, containing 3 moles of the N,N'-diaminourea ligand and the N,N'-dinitrousurea anion. The synthesized substances were identified using NMR, IR, UV spectroscopy and elemental analysis, as well as DSC and TGA analysis. The gross composition calculation performed corresponds to Ni2+((O2NN)2C=O)2-((H2NHN)2C=O)3(H2O).
Метод статусных функций при математическом моделировании фазовых переходов
Authors: Ф.Х. Кудаева 
Published: November 2024

Математическое моделирование и расчет теплопередачи через многослойную среду путем теплопроводности с возможностью возникновения в отдельных слоях фазовых переходов возникает во многих областях, в том числе: в криомедицине, в криобиологии, и в других областях, где происходит фазовый переход. Цель предлагаемой работы: разработка метода обработки шумов, возникающих при низкотемпературном воздействии на биологические ткани. Предложен математический метод, основанный на использовании комплексных статусных функций, выдвинутую В.С.Пугачевым, где случайная функция, над которой нужно произвести те или иные преобразования, представлено в виде суммы элементарных случайных функций, которое называется каноническим разложением. К задачам с фазовыми переходами при низкотемпературном воздействии применен метод, основанный на использовании комплексных статусных функций. С помощью метода статусных функций можно предсказывать состояния системы, которые относятся к случайным функциям. Для заданного набора измерений на основе суперпозиции элементарных случайных функций с весовыми коэффициентами получено распределение, характеризующее состояние. Предложен метод обработки и интерпретации данных измерения ошибок на основе статусных функций, который учитывает взаимовлияние исследуемых процессов. Полученные в настоящей работе результаты могут быть полезны специалистам, которые занимаются задачами со свободными границами.
Mathematical modeling and calculation of heat transfer through a multilayer medium by thermal conductivity with the possibility of phase transitions in individual layers occurs in many fields, including: in cryomedicine, in cryobiology, and in other areas where phase transition occurs. The purpose of the proposed work is to develop a method for processing noise arising from low-temperature exposure to biological tissues. A mathematical method based on the use of complex status functions, put forward by V.S.Pugachev, is proposed, where the random function over which certain transformations need to be performed is represented as a sum of elementary random functions, which is called canonical decomposition. A method based on the use of complex status functions is applied to problems with phase transitions under low-temperature exposure. Using the method of status functions, it is possible to predict the states of the system, which relate to random functions. For a given set of measurements, based on a superposition of elementary random functions with weighting coefficients, a distribution characterizing the state is obtained. A method for processing and interpreting error measurement data based on status functions is proposed, which takes into account the mutual influence of the processes under study. The results obtained in this work can be useful for specialists who deal with tasks with free boundaries.
расчётно-экспериментальные исследования режимов вибронагружения ЭНЕРГЕТИЧЕСКИХ ДВИГАТЕЛЬНЫХ УСТАНОВОК
Authors: Т.С. Поташова , В.Е. Хорошаева , А.А. Трубников , О.В. Поташов , Д.В. Желтов , А.В. Кириллов , Д.П. Титова 
Published: November 2024

В статье рассмотрены частные проблемы отработки энергетических двигательных установок (ЭДУ) с вкладными твёрдотопливными элементами (ТТЭ) связанные с форсированными испытаниями, имитирующими автомобильное и железнодорожное транспортирование. Представлен алгоритм расчёта, позволяющий определять оптимальные режимы имитационных транспортировочных испытаний ЭДУ, устанавливать необходимое время технологических перерывов за счёт отвода тепла из зоны фрикционного контакта в элементы конструкции, что в свою очередь позволит обеспечить безопасность проведения виброиспытаний. Предлагаемый авторами алгоритм расчёта основан на сопряжённом решении одномерной модели сплошного фрикционного контакта с решением дифференциального уравнения теплопроводности. Приведены результаты сопоставления расчётных и экспериментальных данных, иллюстрирующие их хорошее соответствие друг другу (отклонение не превышает 4 %).
The article deals with particular problems of testing energy propulsion systems with embedded solid fuel elements associated with forced tests simulating road and rail transportation. The calculation algorithm is presented, which makes it possible to determine the optimal modes of simulated energy propulsion systems transportation tests, to set the necessary time for technological breaks due to heat removal from the friction contact zone into the structural elements, which in turn will ensure the safety of vibration tests. The algorithm proposed by the authors is based on the conjugate solution of a one-dimensional model of continuous frictional contact with the solution of the differential equation of thermal conductivity. The results of comparing the calculated and experimental data are presented, illustrating their good agreement with each other (the deviation does not exceed 4%).
СИНТЕЗ ПРОИЗВОДНЫХ БИС(ГИДРОКСИМЕТИЛ) 1,4-ДИЗАМЕЩЕННЫХ 1,2,3-ТРИАЗОЛОВ
Authors: Е.О. Шестакова 
Published: November 2024

В статье рассмотрен синтез новых диацетоксиметил- и дихлорметилпроизводных 1,4-дизамещенных 1,2,3-триазолов реакцией ацетилирования уксусныным ангидридом и хлорирования хлористым тионилом исходных 2-нитро-1,3-бис(4,4'-дигидроксиметил)-1,2,3-триазолил-2-азапропана и 3-нитро-1,5-бис(4,4'-дигидроксиметил)-1,2,3-триазолил-3-азапентана. Строение полученных соединений подтверждено методами ИК- и ЯМР-спектроскопии. Данные соединения представляют интерес в качестве исходных веществ для синтеза новых биологически активных и высокоэнергетических веществ.
The article deals with the synthesis of new diacetoxymethyl and dichloromethyl derivatives of 1,4-disubstituted 1,2,3-triazoles by the reaction of acetylation with acetic anhydride and chlorination with thionyl chloride of the starting 2-nitro-1,3-bis(4,4'-dihydroxymethyl)-1,2,3-triazolyl-2-azapropane and 3-nitro-1,5-bis(4,4'-dihydroxymethyl)-1,2,3-triazolyl-3-azapentane. The structure of the obtained compounds is confirmed by IR and NMR spectroscopy. These compounds are of interest as starting materials for the synthesis of new biologically active and high-energy substances.
How Do Transformational Leadership and Affective Trust Enhance Creativity?
Authors: Huynh Thi Thu Suong , Pham Minh 
Published: November 2024

The pressure of competitive higher education has affected most universities, and whether the utilization of human capital as a resource to foster creativity, increase motivation, and boost innovation is an important topic to investigate. This study aims to explore the relationship between the elements of transformational leadership, affective trust, and intrinsic motivation and their impact on creativity to increase the performance of lecturers at Vietnamese universities, where most of them are also creators. Quantitative research is applied with data collected from full-time lecturers at Vietnamese universities from December 2023 to January 2024. The hypothesized correlations were investigated using structural equation modeling on a sample of 311 participants in Vietnam. The findings reveal substantial causal correlations between transformational leadership, affective trust, intrinsic motivation's determinants, and the creativity to improve performance and positive behavior from the lecturers' perspective. These results imply that leaders should focus on the prefix role of transformational leadership, which is the origin of affective trust, intrinsic motivation, and creativity, to raise the standard of higher education. In particular, affective trust needs more attention because it has the most vital mediating role in enhancing the impact of transformational leadership on lecturers' creativity. Doi: 10.28991/ESJ-2024-08-05-011 Full Text: PDF
Demystifying Knowledge Work Practices and Performance in the Public Sector
Authors: Pachayappan Neetha Kumari , Aravindan Kalisri Logeswaran , Alias Mazni , Ramayah T. , Annamalah Sanmugam , Choong Yap Voon 
Published: November 2024

The performance of the public sector, especially its officers, is vital to a nation’s growth in light of the challenges clouding public service. Despite numerous efforts and initiatives, the level of efficiency of Malaysian public sector officers remains feeble, and public dissatisfaction has led to criticism of the administration. Therefore, addressing issues surrounding the performance of public sector officers is imperative to improve public perception. Guided by Drucker’s knowledge work productivity theory, this research aims to discover the relationship between knowledge work practices toward affective commitment (AC) and knowledge worker performance (KWP). This research adopted a cross-sectional design involving a survey of 395 administrative and diplomatic officers who were recruited via stratified random sampling. A variance-based structural equation modeling using Smart PLS 4.0 was conducted to analyze the data. Results show that job crafting (JC) and continuous learning (CL) improve KWP, job-related innovation (JRI) does not impact KWP, and AC exerts a mediating impact on the relationship between knowledge work practices and KWP. This study provides impetus to knowledge productivity and human behavior by integrating JC into Drucker’s theory. Doi: 10.28991/ESJ-2024-08-05-015 Full Text: PDF
The Effect of EAP on Job Performance Based on Psychological Contract and Perceived Organizational Support
Authors: Cai Yinquan , Yii Josephine Ling Chen , Pathak Shubham 
Published: November 2024

In order to study whether employee assistance programs have a significant impact on job performance, whether psychological contract and perceived organizational support play a mediating role in job performance, and thus provide practical operational strategies for relevant enterprises to propose human resource management suggestions to promote job performance, the implementation of employee assistance programs has been the subject of practical research. The findings indicate that addressing issues related to high turnover, job burnout, and absences cannot be separated from the importance of the psychological contract, perceived organizational support, and employee performance in organizational change. By applying structural equation modeling (SEM) to the data from front-line employees of several units in China, this research tested the relationships among employee assistance programs, psychological contracts, perceived organizational support, and job performance using SPSS and AMOS. The results indicate that employee assistance programs positively affect job performance; psychological contracts and perceived organizational support play a mediating role between employee assistance programs and employee job performance (JOP). Our research suggests that an employee assistance program can optimize frontline employee assistance work, build a mechanism to stimulate frontline employees' psychological contracts, and create an organizational environment full of perceived organizational support. This study innovatively uses the structural equation model for quantitative research. In addition, most previous studies on EPA were based on a single variable, psychological contract, and POS were used as the main intermediary variables to explore the mechanism of their impact on job performance so as to enhance the explanatory power of employee job performance. Doi: 10.28991/ESJ-2024-08-05-018 Full Text: PDF
Strategies for Pedagogical Interventions to Develop Emotional Intelligence (EI) of Employees in a Hybrid Work Schedule
Authors: Matulčíková Marta , Breveníková Daniela , Vaľko Michal , Gawrych Roman , Procházka David A. 
Published: November 2024

The purpose of the research article is to identify the educational methods suitable for developing employee emotional intelligence. The focus was on the number of hours that small and medium sized enterprises are willing to invest in training their employees in emotional intelligence and on the benefits, i.e., changes in work outcomes as evaluated by respondents. The questionnaire method and interviews were used to obtain data from respondents, line managers, and education managers. Based on correlation coefficient calculations, brainstorming was identified as a frequently used method of active learning, which is related to the physical presence in the learning premises. The analysis of the responses of the respondents and their calculation using the correlation coefficient surprisingly showed that the lecture method gained great support and was considered by the respondents, i.e., managers and education managers, as very important to achieve the cognitive, affective, and psychomotor goals of education. Moreover, it was assessed as a method suitable for remote learning, i.e., for virtual educational spaces. Doi: 10.28991/ESJ-2024-08-05-023 Full Text: PDF