bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retinal Complications in Patients with Systemic Lupus Erythematosus Treated with Antimalarial Drugs
Authors: Mukwikwi Elvis-Raymond , Pineau Christian A. , Vinet Evelyne , Clarke Ann E. , Nashi Emil , Kalache Fares , Grenier Louis-Pierre , Bernatsky Sasha 
Published: September 2019

Objective.Hydroxychloroquine (HCQ) and chloroquine (CQ) are key drugs in systemic lupus (SLE) and related diseases. Retinal toxicity remains the most worrisome complication. We studied factors potentially associated with retinal toxicity, using case-control analyses.Methods.Within our SLE clinic cohort, we identified patients with retinal changes using the Systemic Lupus International Collaborating Clinics Damage Index. We confirmed HCQ/CQ retinopathy with chart review, and selected up to 3 SLE controls for each case, matched by age at SLE diagnosis and SLE duration.Results.Over an average 12.8 years of followup, within 326 patients exposed to antimalarial drugs, 18 (5.5%) developed retinal toxicity. The minimum number of years of HCQ/CQ exposure before retinopathy developed was 8 years (maximum 33 yrs). Median HCQ/CQ duration was statistically similar in cases [19 yrs, interquartile range (IQR) 14–20] and controls (16 yrs, IQR 11–22), likely due to our matching on SLE duration. Versus controls, cases tended to have more renal disease (cases 22.2%, controls 14.8%) and were slightly less likely to be white (cases 61.1%, controls 74.1%), but neither variable reached statistical significance. Among patients with retinal toxicity, the number previously exposed to CQ was more than 3 times that in controls.Conclusion.Just over 5% of patients developed antimalarial retinal complications, over an average of 12.8 years. No cases were detected in the first 5 years of therapy. Past CQ use was more common in cases versus controls. Future studies using larger cohorts are under way to better define the roles of therapy duration, race/ethnicity, and other factors.
Pregnancy in Systemic Sclerosis: Results of a Systematic Review and Metaanalysis
Authors: Blagojevic Jelena , AlOdhaibi Khitam Abdullah , Aly Aly M. , Bellando-Randone Silvia , Lepri Gemma , Bruni Cosimo , Moggi-Pignone Alberto , Guiducci Serena , Mecacci Federico , Matucci-Cerinic Marco , Furst Daniel E. 
Published: September 2019

Objective.Through a systematic literature search (SLR) and metaanalysis, to determine maternal and fetal outcomes in pregnancies involving systemic sclerosis (SSc), to analyze the effect of pregnancy on disease activity, and to examine predictors of fetal and maternal outcomes.Methods.An SLR was performed for articles on SSc and pregnancy published between 1950 and February 1, 2018. Reviewers double-extracted articles to obtain agreement on > 95% of predefined critical outcomes.Results.Out of 461 publications identified, 16 were included in the metaanalysis. The metaanalysis showed that pregnancies involving SSc were at higher risk of miscarriage (OR 1.6, 95% CI 1.22–2.22), fetuses with intrauterine growth retardation (IUGR; OR 3.2, 95% CI 2.21–4.53), preterm births (OR 2.4, 95% CI 1.14–4.86), and newborns with low birth weight (OR 3.8, 95% CI 2.16–6.56). Patients with SSc had a 2.8 times higher chance of developing gestational hypertension (HTN; OR 2.8, 95% CI 2.28–3.39) and a 2.3 times higher chance of cesarean delivery compared to controls (OR 2.3, 95% CI 1.37–3.8). The definitions of disease worsening/new visceral organ involvement were too inexact to have any confidence in the results, although worsening or new disease manifestations during pregnancy in 44/307 cases (14.3%) and 6 months postpartum in 32/306 cases (10.5%) were reported. The data did not permit definition of predictors of disease progression and of maternal and fetal outcomes.Conclusion.Pregnancies involving SSc have increased frequency of miscarriages, IUGR, preterm deliveries, and newborns with low birth weight compared to healthy controls. Women with SSc were more prone to develop gestational HTN and to undergo cesarean delivery. Disease manifestations seem to remain stable or improve in most patients.
Quality of Care in Childhood-onset Systemic Lupus Erythematosus: Report of an Intervention to Improve Cardiovascular and Bone Health Screening
Authors: Smitherman Emily A. , Huang Bin , Furnier Adam , Taylor Janalee , Burns Mary Beth , Brunner Hermine I. , Morgan Esi M. 
Published: September 2019

ObjectiveInitial benchmarking of childhood-onset systemic lupus erythematosus (cSLE) quality indicators revealed suboptimal performance across multiple centers. Our aim was to improve cardiovascular and bone health screenings at a tertiary treatment center for cSLE. This included annual measurements of vitamin D, lipid profiles, and bone mineral density through dual-energy x-ray absorptiometry (DXA).MethodsQuality improvement methodology was applied to design and implement a standardized previsit planning process to electronically entered and saved orders for needed screenings prior to a scheduled clinic visit. Process outcomes were measured using statistical process control charts. Univariate analyses were completed to assess patient-level factors.ResultsDuring the study, 123 patients with cSLE participated across 619 clinic visits. The percentage of patients with completed screenings improved from 54% to 92% for annual vitamin D, 55% to 84% for annual lipid profiles, and 57% to 78% for DXA, which was sustained for more than 1 year. Providers responded to a majority of abnormal results, and improvement in the average vitamin D level was observed over time. Higher levels of disease activity, damage, number of clinic visits, and screenings completed at baseline were observed in patients with all screenings completed at the end of the intervention.ConclusionImplementation of elements of the chronic illness care model for cSLE management improved performance of cardiovascular and bone health screenings, a step toward preventing longterm morbidity in cSLE. Our study also suggests that more patient interaction with the healthcare system may promote successful completion of health maintenance screenings.
Comparative Persistence of Methotrexate and Tumor Necrosis Factor Inhibitors in Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis
Authors: George Michael D. , Baker Joshua F. , Ogdie Alexis 
Published: September 2019

Objective.The role of methotrexate (MTX) for the treatment of spondyloarthritis (SpA) remains uncertain. Aims were to compare MTX and tumor necrosis factor inhibitor (TNFi) persistence in spondyloarthritis versus rheumatoid arthritis (RA) and to determine whether concomitant conventional synthetic disease-modifying antirheumatic drug (csDMARD) use is associated with improved TNFi persistence in SpA.Methods.This retrospective cohort study using Optum’s deidentified Clinformatics Data Mart Database 2000–2014 identified patients with RA, psoriatic arthritis (PsA), and ankylosing spondylitis (AS) without prior biologic use who were initiating MTX or a TNFi. Cox proportional hazards models compared time to medication discontinuation over the next 2 years between patients with RA, PsA, or AS, adjusting for potential confounders. In similar analyses stratified by disease, Cox models were used to assess whether concomitant use of csDMARD was associated with TNFi persistence.Results.We identified 31,527 MTX initiators (26,708 RA, 2939 PsA, 1880 AS) and 34,651 TNFi initiators (24,134 RA, 6705 PsA, 3812 AS). MTX was discontinued sooner in patients with PsA [adjusted HR (aHR) 1.10, 95% CI 1.04–1.16] and AS (aHR 1.23, 1.16–1.31) versus RA, while TNFi were discontinued at similar rates in RA and AS and discontinued later in PsA (aHR 0.93, 0.89–0.97). Concomitant use of MTX (compared to no csDMARD) was associated with lower rates of TNFi discontinuation in RA (aHR 0.85, 0.80–0.89), PsA (aHR 0.81, 0.74–0.89), and AS (aHR 0.79, 0.67–0.93).Conclusion.MTX discontinuation occurs sooner in patients with PsA and AS versus RA. Concomitant use of MTX with a TNFi, however, is associated with improved TNFi persistence in all 3 diseases.
Outcomes and Findings of the International Rheumatoid Arthritis (RA) BIODAM Cohort for Validation of Soluble Biomarkers in RA
Authors: Maksymowych Walter P. , FitzGerald Oliver , Østergaard Mikkel , Homik Joanne , van der Heijde Désirée , Lambert Robert G. , Elkayam Ori , Ramiro Sofia , Thorne J. Carter , Larché Maggie J. , Ferraccioli Gianfranco , Backhaus Marina , Burmester Gerd R. , Boire Gilles , Combe Bernard , Schaeverbeke Thierry , Saraux Alain , Dougados Maxime , Rossini Maurizio , Govoni Marcello , Sinigaglia Luigi , Cantagrel Alain , Barnabe Cheryl , Bingham Clifton O. , Tak Paul P. , van Schaardenburg Dirkjan , Hammer Hilde Berner , Paschke Joel , Dadashova Rana , Hutchings Edna , Sepriano Alexandre , Landewé Robert 
Published: September 2019

Objective.The Outcome Measures in Rheumatology Soluble Biomarker Working Group initiated an international, multicenter, prospective study, the Rheumatoid Arthritis (RA) BIODAM cohort, to generate resources for the clinical validation of candidate biomarkers predictive of radiographic progression. This first report describes the cohort, clinical outcomes, and radiographic findings.Methods.Patients with RA from 38 sites in 10 countries starting or changing conventional synthetic disease-modifying antirheumatic drugs and/or starting tumor necrosis factor inhibitors were followed for 2 years. Participating physicians were required to adhere to a treat-to-target strategy. Biosamples (serum, urine) were acquired every 3 months, radiography of hands and feet every 6 months, and ultrasound of hands and feet every 3 months in a subset. Primary endpoint was radiographic progression by the Sharp/van der Heijde score.Results.A total of 571 patients were recruited and 439 (76.9%) completed 2-year followup. At baseline, the majority was female (76%), mean age 55.7 years, and mean disease duration 6.5 years. Patients had a mean of 8.4 swollen and 13.6 tender joints, 44-joint count Disease Activity Score (DAS44) 3.8, 77.7% rheumatoid factor–positive or anticitrullinated protein antibody–positive. Percentage of patients in DAS and American College of Rheumatology remission at 2 years was 52.2% and 27.1%, respectively. Percentage of patients with radiographic progression (> 0.5) at 1 and 2 years was 38.2% and 59.9%, respectively.Conclusion.The RA BIODAM prospective study succeeded in generating an extensive list of clinical, imaging (2343 radiographs), and biosample (4638 sera) resources that will be made available to expedite the identification and validation of biomarkers for radiographic damage endpoints. (Clinicaltrials.gov: NCT01476956, clinicaltrials.gov/ct2/show/NCT01476956)
Philipp Abraham Kohnstamm en de serie ‘Psychologie van het ongeloof’ (1933-1939)
Authors: Molendijk Arie L. 
Published: September 2019

Abstract
From 1933 to 1939 a series of eight books was published, titled ‘Psychologie van het ongeloof’ (psychology of unbelief). This article pays attention to Ph.A. Kohnstamm, the initiator and editor of this series, and gives an overview of his religious and scientific development. Kohnstamm was a scientist who converted to Christianity. He developed a Biblical personalism and focused on pedagogy in his later life. This article deals with the genesis of this series on this modern subject, and gives a description of the different authors – from various religious backgrounds and sometimes friends of Kohnstamm – and the contents of each issue, of which H.C. Rümke’s on the relation of character and predisposition to unbelief became famous. Kohnstamm wrote a general introduction to the series. Arie Molendijk questions the psychological character of the series and qualifies the series overall as apologetic.
Vrijmaking (1944) in oorlogstijd
Authors: Langevelde Ab van 
Published: September 2019

Abstract
In 1944, the most difficult year of the war for the Netherlands, a conflict in the Reformed Churches in the Netherlands resulted in a split, the Vrijmaking. Often people have wondered – to say the least – why the Reformed were busy with their internal struggles in a time when national suffering and conflict required all hands to be on deck? A common explanation refers to innere Emigration: focusing on ecclesial issues was a kind of escape from national distress. In church they were like under a glass bell. The participants were aware of the incongruency of the situation, but proceeded with the Vrijmaking nonetheless. Van Langevelde proposes to replace the image of the glass bell by a bee hive, a more porous distinction between church and nation.
Viscous and hysteretic damping
Authors: Labise Chloe C. , Rodgers Geoffrey W. , MacRae Gregory A. , Chase J. Geoffrey 
Published: September 2019

Capacity design, while protecting a structure against undesirable energy dissipations, has major implications on member sizes and overall cost. Furthermore, in some situations where protected elements possess some inelastic deformation capacity, it may be unwarranted. One of these situations is when the forces applied to the protected elements result from viscous dampers. This is because when viscous forces cause yielding in an element, the element deforms, so no deformation in the viscous damper is required. If no deformation is required, the velocity is zero, so there is no force. This implies that very little inelastic yielding is likely to occur in protected elements.
In order to investigate whether or not this is so, a single storey structure was designed and fitted with braces to reduce its response. Both hysteretic and viscous braces were used to obtain the same peak displacement response. The column strength was decreased by a fixed percentage and inelastic dynamic time history analysis was conducted. The amount of energy dissipated in the columns was then compared to determine whether hysteretic braces or viscous braces caused more column yielding so that appropriate over strength values could be developed for different brace types. It was found that the amount of energy absorbed by the column depends on the period but also on the brace design ductility. However, irrespective of the period or design ductility, the column hysteretic energy dissipated by a viscous brace was lower than that dissipated by a hysteretic brace. It follows that column yielding may be significantly less critical for viscous, rather than for hysteresis, braced structures.
The art of surgery
Authors: Sterpetti A V 
Published: September 2019

Abstract
The Polittico della Misericordia (Piero della Francesca, 1444–1462; fresco; Museo Civico di Sansepolcro, Sansepolcro, Italy). The painting includes a self-portrait of the artist in which a thyroglossal cyst is evident. According to Vasari, Piero della Francesca was a calm and wise man, who lived for more than 80 years, supporting the diagnosis of a benign condition. Published online in Wiley Online Library (www.bjs.co.uk). DOI: 10.1002/bjs.11107 Piero della Francesca (1417–1492), an Italian artist of the Renaissance period, did not receive the credit he deserved during his lifetime. He painted several frescos in his home town of Sansepolcro, Italy, after the local government and monastery tried to make the town as attractive as possible, in support of a bid to Rome to be an Episcopal seat. Piero della Francesca painted the fresco Polittico della Misericordia for the altar of the Church of the Confraternita della Misericordia. One of those praying is a self-portrait of the artist. The painter's subjects are arranged symmetrically, which gives a feeling of action, based on careful mathematical and geometrical studies. The importance of Piero della Francesca in the history of art was discovered by English tourists in the mid-19th century, and above all by Austen Henry Layard (1817–1894), one of the most influential archaeologists of the 19th century. During World War II, the commander of the British soldiers received the order to bomb Sansepolcro, which was occupied by the German army. The commander was interested in archaeology and had visited Sansepolcro several times before the war. He therefore decided not to bomb Sansepolcro immediately to avoid destroying the fresco. A couple of weeks later the German soldiers left Sansepolcro, and so the frescos of Piero della Francesca were saved. Read more about the fascinating events surrounding this painting in an essay online.
Avoiding, diagnosing and treating well leg compartment syndrome after pelvic surgery
Authors: Gill M , Fligelstone L , Keating J , Jayne D G , Renton S , Shearman C P , Carlson G L 
Published: September 2019

Abstract

Background
Patients undergoing prolonged pelvic surgery may develop compartment syndrome of one or both lower limbs in the absence of direct trauma or pre-existing vascular disease (well leg compartment syndrome). This condition may have devastating consequences for postoperative recovery, including loss of life or limb, and irreversible disability.

Methods
These guidelines represent the collaboration of a multidisciplinary group of colorectal, vascular and orthopaedic surgeons, acting on behalf of their specialty associations in the UK and Ireland. A systematic analysis of the available peer-reviewed literature was undertaken to provide an evidence base from which these guidelines were developed.

Results
These guidelines encompass the risk factors (both patient- and procedure-related), diagnosis and management of the condition. Key recommendations for the adoption of perioperative strategies to facilitate prevention and effective treatment of well leg compartment syndrome are presented.

Conclusion
All surgeons who carry out abdominopelvic surgical procedures should be aware of well leg compartment syndrome, and instigate policies within their own institution to reduce the risk of this potentially life-changing complication.
Community Curation and Expert Curation of Human Long Noncoding RNAs with LncRNAWiki and LncBook
Authors: Ma Lina , Cao Jiabao , Liu Lin , Li Zhao , Shireen Huma , Pervaiz Nashaiman , Batool Fatima , Raza Rabail Z. , Zou Dong , Bao Yiming , Abbasi Amir A. , Zhang Zhang 
Published: September 2019

AbstractIn recent years, the number of human long noncoding RNAs (lncRNAs) that have been identified has increased exponentially. However, these lncRNAs are poorly annotated compared to protein‐coding genes, posing great challenges for a better understanding of their functional significance and elucidating their complex functioning molecular mechanisms. Here we employ both community and expert curation to yield a comprehensive collection of human lncRNAs and their annotations. Specifically, LncRNAWiki (http://lncrna.big.ac.cn/index.php/Main_Page) uses a wiki‐based community curation model, thus showing great promise in dealing with the flood of biological knowledge, while LncBook (http://bigd.big.ac.cn/lncbook) is an expert curation–based database that provides a complement to LncRNAWiki. LncBook features a comprehensive collection of human lncRNAs and a systematic curation of lncRNAs by multi‐omics data integration, functional annotation, and disease association. These protocols provide step‐by‐step instructions on how to browse and search a specific lncRNA and how to obtain a range of related information including expression, methylation, variation, function, and disease association. © 2019 by John Wiley & Sons, Inc.
Protein‐Protein Interaction Mapping by 2C‐BioID
Authors: Chojnowski Alexandre , Werner Hendrikje , Cook Matthew , Sobota Radoslaw M. , Burke Brian , Stewart Colin L. 
Published: September 2019

AbstractProtein‐protein interactions (PPIs) add an essential layer of complexity to the information encoded by the genome. Modulation of such interactions is a key feature of most, if not all, cellular activities and allows cells to respond rapidly to both internal and external signals and stimuli. In this respect, the development of the BioID assay to interrogate PPIs within a cellular context represents an important adjunct to the range of tools currently at researchers' disposal. To address some of its current limitations, we devised 2C‐BioID, in which biotin ligase and the protein of interest remain as separate entities until induced to associate. This is accomplished using the well‐established FKBP‐FRB dimerization system (based on the rapamycin‐induced binding of FK506 binding protein and FKBP12‐rapamycin binding domain.). The design of 2C‐BioID ensures that biotin ligase association with the protein of interest occurs only after addition of the rapamycin analogue AP21967. As such, 2C‐BioID alleviates potential targeting issues and improves the ability to exclude false positives, thereby refining the specificity of BioID‐generated interactomes. © 2019 by John Wiley & Sons, Inc.
AT1 receptor antagonism promotes bone loss attenuation in experimental periodontitis, blocks inflammatory mediators, and upregulates antioxidant enzymes and bone formation markers
Authors: Dionísio Thiago J. , Souza Gabriela P. , Colombini‐Ishikiriama Bella L. , Garbieri Thais F. , Parisi Viviane A. , Oliveira Gabriela M. , Cano Isadora P. , Rodini Camila O. , Oliveira Sandra H. P. , Greene Andrew S. , Santos Carlos F. 
Published: September 2019

AbstractBackgroundThe initiation and progression of periodontitis might involve a local renin‐angiotensin system in periodontal tissue. This study hypothesized that Losartan treatment could promote protection to rats submitted to experimental periodontitis (EP) by attenuating alveolar bone loss due to reduction in inflammatory cytokines, better reactive oxidant species regulation and maintenance of the balance between bone formation and resorption factors.MethodsOne hundred and thirty rats were submitted to EP with a silk suture thread (4.0) placed around the lower right first molar for 1, 3, 7, and 14 consecutive days. The study comprised four groups: G1—control without EP; G2—animals with EP treated with water; G3—Losartan‐treated animals (treatment started at the same day of EP induction), and G4—animals previously treated with Losartan for 30 days followed by induction of EP and continuity of treatment.ResultsG2 rats had greater bone loss volume, increased number, and thickness and decreased separation of trabeculae. On the other hand, G4 animals showed significant improvements in these parameters. Histological analysis revealed that EP favors inflammatory cell infiltration and junctional epithelium, cementum with alveolar bone crest destruction, but animals pretreated with Losartan (G4) did not show these features. Although the G3 animals did not demonstrate the improvements detected in G4, mRNA expression results were similar. In mandibular tissue, EP promoted mRNA increases for ACE, AT1 receptor, and inflammatory mediators as well as decreases for antioxidant enzymes. However, Losartan treatments attenuated these responses in addition to promoting an increase in bone formation markers and transcription factors.ConclusionAT1 receptor modulates EP progression.