bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bridging the Diagnostic Gap in Neuropsychiatry: The Role of Neuro Acoustic Therapies in Accurate Diagnosis
Authors: Aasim Shahzad , Butt Muheet , Rana Sanjeev , Banal Rakesh 
Published: November 2024

Abstract

Neuropsychiatric disorders, including depression, anxiety, schizophrenia, and bipolar disorder, significantly impact global health, posing challenges in diagnosis and treatment. Traditional diagnostic methods often rely on subjective clinical observations, necessitating more precise and objective tools. The research was carried out at the Kashmir Advanced Scientific Research Centre, a DSIR-recognized institute. The treatment methodology comprises seven phases: registration of Patients, Case History Formulation, therapy awareness, Loop Selection in Active Mode, Frequency Modulation Test (FMT/EEG), Comparing Resonance Value, and Checking for Neuro Psychiatric Disorders and treatment Provisions. Each phase is designed to ensure comprehensive data collection, patient engagement, and accurate diagnosis using sound frequencies. Initial results from a sample of 50 patients previously diagnosed with psychiatric disorders indicate significant diagnostic discrepancies when reassessed with Neuro acoustic loop therapy. Comparative analysis using a confusion matrix revealed that approximately 50% of already diagnosed neuropsychiatric disorders differed from those diagnosed at KASRC. This research proposes a novel, standardised approach for diagnosing neuropsychiatric disorders, integrating Neuro acoustic therapies with conventional methods. The findings suggest that Neuro acoustic stimulation can provide an objective and scalable diagnostic tool, enhancing the accuracy of neuropsychiatric diagnoses and contributing to better patient outcomes. The study aims to establish a robust framework for the effective treatment of neuro psychiatric disorders, advancing mental health care through innovative Neuro acoustic methodologies.
Prevalence of borderline personality disorder among Syrian private university students, a cross-sectional study.
Authors: Kharfan Bilal , Yousef Haidar , Mhanna Fares Asaad , Lattifeh Youssef 
Published: November 2024

Abstract

Background Borderline personality disorder (BPD) is characterized by changes in selfimage and interpersonal relationships that are characterized by sudden shifts between idealization (overly positive views of self and others) and devaluation (overly negative views of self and others). People with borderline personality disorder typically suffers from anxiety, irritability, and affective disorder as well as impulsive behaviors related to spending (Profusion), sexual activity, drugs abuse, or polyphagia. Borderline personality disorder affects approximately 0.7–2.7% of adults.
Purpose The aim of this study is to assess the prevalence of borderline personality disorder (BPD) among undergraduate students at the Syrian Private University (SPU), Damascus, Syria, where we seek to diagnose the presence of the disorder in addition to studying the impact of many factors whether those related to childhood or adulthood, from environmental, material, emotional, family and even academic conditions, and studying the manifestations that are common in this group of students.
Methods: After obtaining approval from the Deanship of the Faculty of Medicine and the Ethics Committee at the Syrian Private University SPU, We designed an electronic questionnaire and distributed it randomly among students with informed consent from the participating student in a mandatory option to participate in the questionnaire. The questionnaire did not include any personal information referring to the participating student, but rather demographic data and variables related to our study. We designed the questionnaire and distributed it among students in the period between 5/1/2024 - 10/1/2024 and obtained 250 participating students, We excluded 30 students for not completing the questionnaire optimally and selected 220 students.
Results we found a statistically significant association between the incidence of the Borderline Personality Disorder (BPD) and the age, gender, and the emotional and family status on the incidence, but there was no significant effect of financial status, finally there was a relation between the incidence and a history of early separation from the partner.
Chemical Synthesis and Enzymatic Modification of Mangostins: A Comprehensive Review on Structural Modifications for Drug Discover
Authors: Lew Jordan Joon-Yip , Choo Yeun-Mun 
Published: November 2024

Abstract:
Mangosteens, a prominent component of Garcinia mangostana, have been ex-tensively studied for their biological activities and structural modifications. Chemical methods, including cyclization reactions under acidic conditions, have yielded many de-rivatives, which often exhibit enhanced pharmacological properties compared to itself. Enzymatic biotransformation, such as glycosylation and oxidation mediated by fungal species and enzymes like horseradish peroxidase, have provided regioselective pathways to functionalized mangostin derivatives. These studies highlight the versatility of mangos-tin as a scaffold for designing compounds with tailored biological functions. Overall, mangosteen represents a promising platform for developing compounds with enhanced pharmacological activities, paving the way for innovative approaches in biomedicine and pharmaceutical sciences. This review provides a comprehensive examination of the chem-istry of mangosteens, detailing their total synthesis and the derivatives obtained through both chemical and enzymatic methodologies.
Idebenone Attenuates Diabetic Retinopathy by Modulating Autophagy Via Targeting Akt Signaling
Authors: Yu Zhenqian , Liu Gang 
Published: November 2024

Introduction:
Diabetic Retinopathy (DR) is a common microvascular issue
caused by diabetes. Idebenone (IDE) is a coenzyme Q10 analog and antioxidant that has
been utilized in the treatment of neurodegenerative diseases.

Method:
Our goal was to investigate how IDE might treat diabetic retinopathy. An in
vivo DR model was established by injecting a single dose of streptozotocin (STZ). Rats
were treated with IDE, and their vascular function was measured by ultrasound. The retina
structure was checked by haematoxylin and eosin (HE) staining. The expression of
biomarkers of autophagy and apoptosis was measured by western blotting assay. The
retina endothelial cell line RF/6A was stimulated with high glucose (HG) and treated
with IDE. Cell proliferation and apoptosis were assessed using the Edu assay, TUNEL
assay, and flow cytometry, respectively.

Result:
Reduced peak systolic velocity (PSV), mean velocity (MV), end-diastolic velocity
(EDV), and increased pulsatility index (PI) and resistance index (RI) were observed
in diabetic rats; however, these traits were reversed by IDE therapy. IDE alleviated the
STZ-induced disordered retina structure. The IDE administration suppressed DR-induced
apoptosis and autophagy both in vivo and in vitro. IDE suppressed the activation
of Phosphatidylinositol 3 kinase (PI3K) signaling. Activation of PI3K abolished the
IDE-alleviated retina damage and cell death.

Conclusion:
IDE regulated the autophagy of retina cells to alleviate diabetic retinopathy
via regulating the PI3K signaling pathway.
Establishing a Novel Pyroptosis-Related Gene Signature and Predicting Chemical Drugs for Papillary Thyroid Cancer
Authors: Wang Ru , Chen Xin , Yi Dandan , Jiang Chaoyu , Xu Fazhan , Qin Jiabo , Lee YiHsuan , Sang Jianfeng , Shi Xianbiao 
Published: November 2024

Background:
The present study aimed to construct a novel pyroptosis-related gene
signature to predict the prognosis of papillary thyroid cancer (PTC).

Methods:
The gene expression level and survival and prognosis information of PTC were obtained
from TCGA. The differentially expressed pyroptosis-related genes (DEPs) between cancer
and control groups were selected, followed by subtype analysis. A prognostic model was built
using LASSO regression analysis. The samples were then divided into high- and low-risk groups,
and the differences in immune cell distribution in different risk groups were compared. The chemical
drugs associated with genes in the prognostic model were extracted from the Comparative
Toxicogenomics Database.

Results:
A total of 31 DEPs were selected, and 3 different subtypes were obtained. A prognostic
model based on 6 pyroptosis-related genes was constructed. The risk grouping was significantly
correlated with the actual prognosis, and the model was found to be an independent prognostic
factor. Six immune cells with significant differences in distribution in different risk groups were
screened. CGP52608 could target four genes in the prognostic model, including GSDMB,
NLRC4, IL1A, and IL6.

Conclusion:
The present study constructed a pyroptosis-related gene signature that could predict
the prognosis of PTC. Additionally, this signature was correlated with tumor immunity.
Biochemical Screening, In-vitro and In-silico Characterization of Citrullus colocynthis Fruit Extracts: A Combined Experimental and Computation
Study
Authors: Shehzadi Syeda Aaliya , Ashraf Muhammad Ayaz , Shafiq Nusrat , Rida Fatima , Javed Aneela , Younas Farhan , Waqar-Un-Nisa  , Younus Waleed 
Published: November 2024

Background:
Several medicinal plants are identified as therapeutic agents for the
world’s most deadly disease cancer. A member of the "Cucurbitaceae" family of medicinal
plants, Citrullus colocynthis (C. colocynthis) has various pharmacological actions.

Aims and Objectives:
In the present study we have focused on the phytochemical analysis, antimicrobial,
anticancer and in silico investigation of fruit extracts of C. colocynthis. The chloroform,
pure ethanolic and aq. ethanolic extracts of C. colocynthis whole fruit, peel and pulp separately
have been investigated.

Methods:
The phytochemical analysis revealed the presence of alkaloids, flavonoids, steroids,
phenols, saponins and glycosides in various parts of the fruit. Some compounds have been identified
using GC-MS analysis by comparing with NIST library data. The antimicrobial activity of
all extracts was checked by agar well diffusion method against five different bacterial strains
such as A. baumannii, K. pneumonia, S. aureus, P. aeruginosa and E. coli. The zone of inhibition
(ZOI) ranged between 11 mm to 27 mm against different strains.

Results:
The polar solvent extracts (ethanolic and aq. ethanolic extract) of peel showed good
sensitivity against all bacterial strains as compared to non-polar solvent (chloroform extract),
which showed activity only against Staphylococcus aureus and Pseudomonas aeruginosa. The
cytotoxic activity of C. colocynthis all extracts against human brain cancer cell lines (U-87) was
assessed using MTT assay.

Conclusion:
The % cell viability of ethanolic (ET-PL), and aq. ethanolic extract of whole fruit
and pulp showed promising results. The cancerous cell line U-87 seems to be more sensitive
towards polar solvents (ethanolic and aq. ethanolic) pulp extracts than peel. Further, based on invitro
results, compounds identified in ET-PP were screened for their potential as antibacterial
and anticancer agents through molecular docking and MMGBSA studies. These studies strongly
supported the in-vitro study results and identified new drug candidates.
Enhanced Neuroprotection in Experiment Multiple Sclerosis through Combined Rosiglitazone and Probiotic-Loaded Solid Lipid Nanoparticles:
Modulation of Cellular Signaling Pathways
Authors: Kumar Nitish , Tyagi Nidhi , Mehan Sidharth , Singh Alok Pratap 
Published: November 2024

Background:
Multiple sclerosis (MS) is a persistent autoimmune condition characterized
by inflammation and neurodegeneration. The current efficacy of treatments is limited, which has
generated interest in developing neuroprotective strategies. Solid lipid nanoparticles (SLNs) and
probiotics are potential drug delivery vehicles for targeting the CNS (Central nervous system), regulating
immune responses, and supporting neuroprotection in neurological conditions.

Methods:
The study investigates how SLNs containing RSG (rosiglitazone) and probiotics can protect
the nervous system in cases of MS. We administered toxin EtBr (Ethidium bromide) from day 1
to day 7, later followed by the treatment from day 8 to day 35. During this time interval, various
behavioural parameters have been performed. Further, after 35th day, blood plasma of animals was
collected to study complete CBC profiling and animals were sacrificed. Then, biochemical and
molecular studies, gross morphology of brain sectioning, histopathological evaluation and
estimation of fatty acid content in fecal matter were performed.

Results:
RSG shows neuroprotective effects by blocking the STAT-3 and mTOR signaling pathways
and increasing the production of PPAR-gamma. GW9662, a PPAR-gamma antagonist given at
a dose of 2 mg/kg (i.p), was utilized to evaluate the role of PPAR-gamma and to compare the efficacy
of RSG and probiotic-loaded SLNs in potentially providing neuroprotection. The relationship between
RSG and the STAT-3, mTOR, and PPAR-gamma pathways in MS was confirmed and validated
using in-silico analysis. RSG and probiotic-loaded SLNs modulate the complete blood profiling
of rats and improve the symptoms of MS. We assessed the diagnostic capabilities of different
biological samples such as cerebrospinal fluid, blood plasma, and brain homogenates (specifically
from the hippocampus, striatum, cortex, and midbrain) to analyze neurochemical changes linked to
neurobehavioral changes in the progression of MS.

Conclusion:
The study showed that combining RSG and probiotics in an experimental medication
form improved symptoms of MS more effectively than using RSG alone. This improvement is likely
due to changes in STAT-3, mTOR, and PPAR-gamma signaling pathways.

result:
The study showed that combining RSG and probiotics in an experimental medication form improved symptoms of multiple sclerosis more effectively than using RSG alone. This improvement is likely due to changes in STAT-3, mTOR, and PPAR-gamma signaling pathways.
Nghiên cứu khả năng xử lý chất dinh dưỡng và chất hữu cơ trong nước mặt của một số loài thực vật thủy sinh
Authors: Hồ Ngô Anh Đào , Nguyễn Thị Minh Trang , Lê Quang Huy 
Published: November 2024

Trong nghiên cứu này, các thí nghiệm nuôi trồng riêng lẻ và kết hợp ba loài thực vật thủy sinh (TVTS), gồm dương xỉ lá hẹp, cú cơm và bèo tai chuột trong các mẫu nước mặt thu tại các hồ cảnh quan (quận 7, thành phố Hồ Chí Minh) được thực hiện nhằm mục tiêu cải thiện chất lượng nước hồ. Dựa trên phương pháp phân tích chất lượng các mẫu nước theo thời gian và sự sinh trưởng của 3 loài TVTS, nghiên cứu đã chứng minh vai trò của ba loài TVTS trong việc loại bỏ các thành phần hữu cơ và chất dinh dưỡng trong các mẫu nước. Trong đó, cú cơm có hiệu suất xử lý chất dinh dưỡng cao nhất với tổng nitơ (TN) (66,7 – 82,1%) và tổng phốt pho (TP) (86,9 – 92,3%). Dương xỉ lá hẹp có khả năng xử lý chất hữu cơ cao nhất (hiệu suất BOD đạt 3,9 – 14%) và bèo tai chuột có hiệu suất thấp nhất. Nghiên cứu cũng xác định được tỷ lệ nuôi trồng kết hợp tốt nhất giữa dương xỉ lá hẹp và cú cơm là 1:2 (theo khối lượng), với hiệu suất xử lý ở cả 2 mẫu nước: BOD5 (29,78%), TN (66,66%), TP (91,67%), Coliform (64,86%) đối với mẫu nước hồ cảnh quan nội vi; và BOD5 (32,08%), TN (60%), TP (92,85%), Coliform (16,67%) đối với mẫu nước hồ cảnh quan ngoại vi.
Siasat Kebudayaan Komunitas Adat Dayak Lepoq terhadap Kebijakan Pelarangan Membakar Lahan di Desa Lung Anai Kecamatan Loa Kulu Kabupaten Kutai Kartanegara
Authors: Dini Wa , Arifin Muhammad 
Published: November 2024

This study focused on the cultural strategies of the Dayak Kenyah traditional community in Lung Anai Village in farming practices as a response to the government policy concerning controlling forest and land burn. The cultural strategy referred to was a social practice related to the management and utilization of local resources, including the practice of local wisdom in farming in the form of burning which is passed down from one generation to the next. The research method that the researcher used was a type of qualitative descriptive research with data collection carried out by means of observation and in-depth interviews. The findings from this research were that the response of the Dayak Kenyah Lung Anai to the policy of prohibiting land burning was very diverse. The public responded to this policy in two ways, namely attitudes and actions. Their attitude was gossip and the actions of the community were carrying out one-time demonstrations. The Lung Anai community had a closed resistance, namely burning in the afternoon until evening, providing barriers, asking companies for help, using village land, increasing income. The conclusion of this research is that the cultural tactics carried out is a form of resistance by indigenous communities to government policies in order to survive by maintaining their traditions in the practice of managing and utilizing local resources.
AMONITAS DEL JURÁSICO SUPERIOR Y DEL CRETÁCICO INFERIOR DEL EXTREMO ORIENTAL DEL ESTADO DE DURANGO, MÉXICO
Authors: Peña Muñoz Magdalena Josefina 
Published: November 2024

Este trabajo consiste en el estudio de amonitas procedentes de una región situada en el extremo oriental del Estado de Durango, que pertenecen a formaciones del Jurásico Superior y del Cretácico Inferior. Se describen 15 géneros y 25 especies, entre las cuales hay una especie nueva (Substeueroceras durangoensis) y una subespecie nueva (Perisphinctes (Dichotomosphinctes) neohispanicus guadalupensis).
CATÁLOGO DE EQUINOIDES FÓSILES DE MÉXICO
Authors: Buitrón-Sánchez Blanca E. 
Published: November 2024

En el presente catálogo se sigue el siguiente plan: después del nombre de la especie, siguen todas las citas de esa especie por orden cronológico, mencionándose primero el autor, el año de publicación, página, lámina y figura. Enseguida el dato de la localidad. Este catálogo comprende únicamente el registro de todas las referencias que se han hecho de equinoides fósiles de México, pero no constituye una revisión de la taxonomía o de la nomenclatura, ni tampoco de la posición estratigráfica o de la localidad. Se presentan estos datos tal y como se encuentran en los trabajos originales, a sabiendas de que algunos de estos datos ya han sido corregidos.
Respecto a los equinoides del Terciario, sólamente se registran aquí aquellas especies que no se mencionaron en el catálogo de Caso, por tratarse en la mayoría de las ocasiones de trabajos que aparecieron posteriormente.
MONOGRAFÍA DE LOS MOLUSCOS DEL MIOCENO MEDIO DE SANTA ROSA, VERACRUZ, MÉXICO PARTE III (GASTERÓPODOS: PYRAMIDELLIDAE A SIPHONARIIDAE) Y PARTE IV (ESCAFÓDODOS: DENTALIIDAE, SIPHONODENTALIIDAE)
Authors: Perrilliat Montoya Maria del Carmen 
Published: November 2024

En este trabajo se describen e ilustran cuarenta y una especie de gasterópodos, de las cuales cinco son nuevas: Eumela (Eulimella) bartschi, Acteon (Acteon) pilsbryi, Acteon (Acteon) dalli, Rindgicula (Ringiculella) subrectus, Atys (Aliculastrum) santarosaensis.
El material procede de la formación Agueguexquite de la parte superior del Mioceno Medio de la región suroriental del Estado de Veracruz.
10th International Congress on the Jurassic System
Authors: Villaseñor Martínez Ana Bertha , Rosales Domínguez Carmen , Olóriz-Sáez Federico 
Published: November 2024

These are the Congress Memories of the 10th International Congress of Jurassic System. This congress took place on the 4-9 of February 2018 in San Luis Potosí, Mexico.
Management of Previable Rupture of Membranes with Prolonged Latency
Authors: Elias Heidi , Thiessen Kellie 
Published: November 2024

Preterm prelabor rupture of membranes at pre-viable gestations (<23–24 weeks) complicates approximately 0.1–0.8% of pregnancies. Few cases of pre-viable preterm prelabor rupture of membranes (pPPROM) have resulted in term delivery, and even fewer have experienced no complications. The case presented sustained a 21-week (147-day) latency period after confirmed pPPROM at 18+6 weeks gestation, resulting in term delivery with exceptional outcomes for both mother and baby. Expectant management with minimal intervention, due to the client’s decline of more invasive options, makes this case unique. A focused literature review was conducted to identify other rare cases of pPPROM. We were particularly interested in understanding the different approaches to managing two similar cases with prolonged latency. We highlight the variations and outcomes of expectant management of pPPROM. Despite the demonstrated benefits of recommended interventions in the expectant management of pPPROM cases, the potential side effects and outcomes of these interventions may be undesirable for patients, leading to their decline. This case underscores the importance of careful counseling regarding management options and the individualization of care based on client risk tolerance.
RÉSUMÉLa rupture prématurée des membranes avant travail à des stades de gestation pré-viables (<23-24 semaines) complique environ 0,1-0,8% des grossesses. Peu de cas ont connu une rupture prématurée des membranes avant travail (RPMT), qui aboutit à un accouchement à terme, et encore moins de cas n’ont pas eu de complications. Le cas présenté a connu une période de latence de 21 semaines (147 jours) après une RPPM confirmée à 18+6 semaines de gestation et s’est soldé par un accouchement à terme avec des résultats exceptionnels pour la mère et le bébé. La gestion de l’attente avec une intervention minimale en raison du déclin de la cliente rend cette gestion de cas unique. Une analyse documentaire ciblée a été réalisée afin d’identifier d’autres cas rares de pPPROM. Nous voulions en particulier comprendre les différentes approches de la gestion de deux cas similaires avec une latence prolongée. Nous soulignons ensuite les variations et les résultats de la prise en charge attendue de la pPPROM. Malgré les avantages démontrés des interventions recommandées dans la prise en charge des cas de pPPROM, les effets secondaires potentiels et les résultats des interventions peuvent être indésirables pour les patients et entraîner leur déclin. Ce cas souligne l’importance d’un conseil attentif sur les options de prise en charge et de l’individualisation des soins en fonction de la tolérance au risque du client.