bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategi Meningkatkan Daya Tarik Wisata Pantai Jatimalang, Kecamatan Purwodadi, Kabupaten Purworejo
Authors: Rahmawaty Mitha Asyita , Alhakim M. T. , Harjanti I. M. , Anggraini P. 
Published: November 2024

Pantai Jatimalang terkenal dan menarik pengunjung dari dalam dan luar daerah, termasuk wisatawan asing. Namun, jumlah pengunjung mengalami fluktuasi setiap tahun. Untuk mempertahankan minat wisatawan, pengembangan Pantai Jatimalang perlu direncanakan, mengingat infrastruktur pendukung pariwisata masih kurang memadai. Kegiatan wisata juga harus diperluas untuk meningkatkan pengalaman pengunjung dan keberlanjutan objek wisata. Analisis SWOT digunakan untuk mengidentifikasi faktor internal dan eksternal yang memengaruhi pengembangan objek wisata ini. Menurut hasil analisis pada penelitian ini Penerapan stategi pengembangan dibagi kedalam strategi S-O dan S-T yang digunakan untuk memanfaatkan seluruh kekuatan dan memaksimalkan peluang sebesar-besarnya dan menghindari/mengatasi ancaman yang ada .Strategi W-O yang digunakan untuk memperbaiki kelemahan dan menggunakan peluang serta menghindari ancaman. Hal ini dapat meningkatkan pengalaman pengunjung sekaligus menjaga keberlanjutan lingkungan.
Рівні брадикініну та інтерлейкіну-6 у крові хворих на COVID-19 та цукровий діабет
Authors: Pushkarev V.V. , Levchuk N.I. , Sokolova L.K. , Pushkarev V.M. , Kovzun O.I. , Tronko M.D. 
Published: November 2024

Для пояснення причин гострого респіраторного синдрому, який виникає внаслідок інфікування SARS–CoV-2 (severe acute respiratory syndrome-related coronavirus 2) висунуті дві головні гіпотези: теорія цитокінового шторму та теорія брадикінінового (БК) шторму. З погляду цитокінового шторму, підвищення рівня цитокінів, у першу чергу інтерлейкіну-6, викликає багатосистемні патологічні прояви COVID-19, включаючи гостре ураження легенів і респіраторний дистрес-синдром у тяжкохворих пацієнтів. Теорія БК шторму підкреслює важливість зниження кількості ангіотензинперетворюючих ферментів в епітеліальних клітинах легенів, що призводить до нездатності розщеплювати БК та його аналог des-Arg9-BK. Метою роботи було порівняльне дослідження рівнів БК у крові хворих на цукровий діабет (ЦД) та пацієнтів, що перехворіли легкою і важкою формами COVID-19. Матеріал і методи. Кров отримували за допомогою стандартної венепункції та зберігали в пробірках з ЕДТА. Плазму відокремлювали центрифугуванням протягом 10 хв після забору крові. Кількість БК визначали за допомогою наборів для імуноферментного аналізу ab136936 («Abcam», Велика Британія), інтерлейкіну-6 (n=36) – EH2IL6 («Invitrogen», Austria). Результати. Показано, що рівень БК вірогідно зростав у хворих на ЦД. У хворих на ЦД і COVID-19 спостерігалося незначне зростання кількості БК. Водночас кількість інтерлейкіну-6 вірогідно зростала у хворих на ЦД і, особливо, у хворих гострим COVID-19. Висновки. Зростання рівня брадикініну в крові хворих на ЦД із COVID-19 визначається головним чином захворюванням на ЦД. У хворих гострою COVID-19 рівень прозапального цитокіна IL-6 зростав майже в три рази порівняно з контролем.
A deeper look at long-term effects of COVID-19 on myocardial function in survivors with no prior heart diseases: a GRADE approach systematic review and meta-analysis
Authors: Dehghan Mahshid , Mirzohreh Seyedeh-Tarlan , Kaviani Raheleh , Yousefi Shiva , Pourmehran Yasaman 
Published: November 2024

ObjectivesThe COVID-19 pandemic has challenged global health systems since December 2019, with the novel virus SARS-CoV-2 causing multi-systemic disease, including heart complications. While acute cardiac effects are well-known, long-term implications are understudied. This review hopes to fill a gap in the literature and provide valuable insights into the long-term cardiac consequences of the virus, which can inform future public health policies and clinical practices.MethodsThis systematic review was prepared using PRISMA reporting guidelines. The databases searched were PubMed, Scopus, Web of Science, and Cochrane. Risk of Bias was assessed using ROBINS-I. The GRADE approach was employed to evaluate the level of certainty in the evidence for each outcome. A meta-analysis was conducted using the Comprehensive Meta-Analysis (CMA) software. In order to identify the underlying cause of high heterogeneity, a subgroup analysis was conducted. Sensitivity analysis was checked.ResultsSixty-six studies were included in this review. Thirty-two of them enrolled in meta-analysis and the rest in qualitative synthesis. Most outcomes showed a moderate certainty of evidence according to the GRADE framework. Post-COVID individuals with no prior heart diseases showed significant changes in left ventricular (LV) and right ventricular (RV) echocardiographic indices compared to controls. These significant findings were seen in both post-acute and long-COVID survivors regardless of the severity of initial infection.ConclusionThis review implies that individuals recovering from post-acute and long-term effects of COVID-19 may experience changes in myocardial function as a result of the novel coronavirus. These changes, along with cardiac symptoms, have been observed in patients without prior heart diseases or comorbidities.Systematic Review RegistrationPROSPERO, identifier (CRD42024481337).
Effects of the Learning how to motivate training on pupils’ motivation and engagement during pre-service physical education teachers’ internship
Authors: Girard Stéphanie , de Guise Audrey-Anne 
Published: November 2024

IntroductionPre-service physical education (PE) teachers have concerns about how to sustain pupils’ motivation. A training titled Learning how to motivate was designed to address these concerns.ObjectivesThe aims of the study were (1) to compare the perceptions of high school pupils of pre-service PE teachers who had completed the training [experimental group (EG)] and pre-service PE teachers who had not completed the training [control group (CG)] about motivation; (2) to verify changes in the perceptions of EG and CG high school pupils with regard to motivational variables between the beginning and end of the internship; and (3) to compare observations of the motivational climate established by the pre-service PE teachers and of their pupils’ engagement between EG and CG.MethodsThe study involves a sample of four French-Canadian pre-service PE teachers (EG = 2; CG = 2) and their high school pupils (n = 89) during the pre-service PE teachers’ final internship. Data were collected using observations and questionnaires at the start (T1) and end (T2) of the internship.ResultsFindings revealed no significant differences between groups at T1. At T2, the EG exhibited higher levels of pupils’ perceived dimensions of an empowering motivational climate than the CG. Notably, between T1 and T2, performance-approach goals decreased, and external regulation increased in the EG. As for the CG, pupils’ perceived dimensions of an empowering motivational climate, competence satisfaction, and performance-approach goals decreased. Finally, there were some trends (p ≤ 0.15) related to differences between the groups for observed motivational climate and pupils’ engagement.ConclusionThe training shows promise with regard to helping pre-service PE teachers apply theory to practice.
Examining the effect of AI-powered virtual-human training on STEM majors’ self-regulated learning behavior
Authors: Glick Danny , Miedijensky Shirley , Zhang Huiyu 
Published: November 2024

IntroductionStudents pursuing science, technology, engineering, and math (STEM) majors often struggle with essential skills critical to their academic success and future careers. Traditional self-regulated learning (SRL) training programs, while effective, require significant time investments from both students and instructors, limiting their feasibility in large lecture-based STEM courses.MethodsThis study investigates whether completion of three AI-powered virtual-human training modules—focused on planning, self-monitoring, and reflection—leads to increased use of corresponding MS Planner tools among STEM majors compared to a control group.ResultsResults indicate that students who did not complete the first two training modules were less likely to use MS Planner features for planning and self-monitoring; however, the reflection module did not yield comparable results.DiscussionThese findings highlight the potential of AI-powered virtual-human training as a scalable solution to enhance desirable learning behaviors among STEM majors, particularly in large and diverse classrooms. This research contributes to the understanding of effective interventions for fostering SRL behaviors in STEM education and suggests avenues for future refinement and implementation of digital training tools.
The triglyceride-to-high-density lipoprotein cholesterol ratio is associated with an increased risk of peripartum cardiomyopathy
Authors: Chen Naiyi , Xiao Jie , Luo Yijie , Fu Kang , Sun Ziru , Zhang Xinyu , Liu Yanan , Lu Huixia , Ji Xiaoping 
Published: November 2024

BackgroundPeripartum cardiomyopathy (PPCM) is a form of heart failure that severely affects women during the late stages of pregnancy and in the postpartum period. Currently, the diagnosis of PPCM is not fully understood and is likely multifactorial. Abnormal lipid metabolism plays an important role in the onset of cardiovascular diseases, especially in patients with heart failure. Moreover, animal experiments have confirmed a possible association between abnormal lipid metabolism and PPCM onset. However, clinical evidence is currently lacking, and reliable and effective indicators for predicting the onset of PPCM are insufficient. The ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) is a novel metabolic marker that is associated with the risk of coronary heart disease. However, the relationship between the TG/HDL-C ratio and the risk of PPCM in parturients remains unknown. Therefore, this study aimed to explore the role of the TG/HDL-C ratio in predicting the risk of PPCM.MethodsThis study included 600 parturients hospitalized at Qilu Hospital of Shandong University between January 2010 and August 2023 (150 patients with PPCM and 450 healthy parturients). The TG/HDL-C ratio was calculated as triglyceride levels (mmol/L)/high-density lipoprotein cholesterol levels (mmol/L). The relationship between the TG/HDL-C ratio and PPCM was analyzed using logistic regression analysis and receiver operating characteristic curve analysis.ResultsSignificant differences were observed in the TG/HDL-C ratio between patients with PPCM and healthy parturients. The TG/HDL-C ratio was higher in patients with PPCM than in healthy parturients (p &lt; 0.001). Logistic regression analysis revealed that the TG/HDL-C ratio increased the risk of PPCM and had predictive accuracy for the onset of PPCM (odds ratio, 1.249; 95% confidence interval, 1.004–1.553; p = 0.046). Moreover, the TG/HDL-C ratio was positively correlated with the NT-proBNP levels at the onset of PPCM (R2 = 0.081, p = 0.008).ConclusionsA higher TG/HDL-C ratio was significantly associated with the risk of PPCM.
Efficacy and safety of once-weekly insulin versus once-daily insulin in patients with type 1 and type 2 diabetes mellitus: an updated meta-analysis of randomized controlled trials
Authors: Xue Mei , Shen Pan , Tang Jun , Deng Xuan , Dai Zhe 
Published: November 2024

BackgroundThis meta-analysis was performed to obtain a comprehensive overview of the differences between once-weekly basal insulin (including icodec and basal insulin Fc) and once-daily basal insulin (including glargine and degludec) in patients with type 1 and type 2 diabetes mellitus.MethodsPubMed, EMBASE, and Cochrane Library were systematically searched for eligible studies up to 2 January 2024.ResultsA total of 12 studies were included, comprising 5,895 patients, with 3,104 (52.7%) using once-weekly insulin and 2,791 (47.3%) using once-daily insulin. In the pooled data, glycated hemoglobin (HbA1c) change from baseline [mean difference (MD) -0.11%; 95% confidence interval (CI) -0.20 to -0.01%] and the odds of achieving an end-of-trial HbA1c &lt;7% (OR 1.41, 95% CI 1.13, 1.77) demonstrated a significantly good glycemic control in the once-weekly insulin group, especially in insulin-naïve type 2 diabetics or patients using icodec. Body weight increase for once-weekly insulin was 0.43 kg compared to controls (95% CI 0.09 to 0.76 kg). In addition, once-weekly insulin was correlated with a higher risk of level 1 hypoglycemia (OR 1.42, 95% CI 1.26 to 1.6). There was no significant difference in fasting plasma glucose (MD 2.46 mg/dL; 95% CI -2.60 to 7.52 mg/dL), time in range (MD 2.03%; 95% CI -0.50 to 4.56%), and level 2 or 3 hypoglycemic events (OR 1.19; 95% CI 0.93 to 1.53).ConclusionsOnce-weekly basal insulin is safe and effective in modestly reducing HbA1c with similar level 2 or 3 hypoglycemic events compared to once-daily insulin, although the risk of level 1 hypoglycemia and weight gain was slightly increased.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO, Identifier CRD42024496812.
Impact of Ureaplasma urealyticum infection on semen parameters and in vitro fertilization outcomes in infertile men
Authors: Wan Yangyang , Chen Xin , Chen Zhaoyu , Liu Wenjing , Li Siyao , Hua Juan 
Published: November 2024

IntroductionUreaplasma urealyticum (UU) is a common pathogen associated with genital tract infections in infertile males. However, its impact on semen quality, embryo development, and in vitro fertilization (IVF) outcomes remains underexplored. This study aims to evaluate the effect of male UU infection on semen parameters, embryo development, pregnancy outcomes, and neonatal health in infertile couples.MethodsA retrospective analysis was conducted on 1,215 infertile couples at the First Hospital of USTC. Participants were divided into two groups based on the male partner’s UU infection status: UU-positive (n=249) and UU-negative (n=966). Semen parameters (sperm concentration, motility, morphology, anti-sperm antibodies, DNA stainability) were assessed. Embryo development was evaluated through fertilization rates and blastocyst formation rates. Pregnancy outcomes (clinical pregnancy, live birth rates, miscarriage rate) and neonatal health (gestational age, birth weight, Apgar scores, preterm delivery) were also compared.ResultsSemen parameters, including sperm concentration, motility, and morphology, were similar between the UU-positive and UU-negative groups. However, the UU-positive group had significantly higher levels of anti-sperm antibodies (ASA) (p=0.020) and higher DNA stainability (HDS) (p=0.014). Despite these differences, embryo quality, as measured by fertilization rates and blastocyst formation rates, was not significantly different between the two groups. Pregnancy outcomes, including clinical pregnancy and live birth rates, were also comparable. While the UU-positive group had a slightly higher miscarriage rate, this difference was not statistically significant. Neonatal outcomes, including gestational age, birth weight, Apgar scores, and preterm delivery rate, did not differ significantly between the two groups.DiscussionThe study suggests that while male UU infection may adversely affect certain semen parameters, its impact on IVF outcomes—such as embryo quality, pregnancy rates, and neonatal health—appears to be minimal. These findings support the continued use of IVF as a viable and safe option for infertile couples with male UU infection, as it does not significantly influence reproductive or neonatal outcomes.
Impact of gradient zero-valent iron pollution from steel works on soil microaggregate geochemical processes and dissipative structures
Authors: Li Chunjie , Xu Wenbo , Guo Shili , Shang Songhao , Li B. Larry 
Published: November 2024

Abstract: Zero-valent iron (ZVI) contamination from steel works poses significant threats to soil quality and ecosystem health, particularly affecting soil microaggregates, which are fundamental to soil structure and function. In this study, we systematically investigated the impact of gradient ZVI pollution on the organic geochemical environment of soil microaggregates around steel works located in the core water source area of the Middle Route of the South-to-North Water Diversion Project in China. Advanced analytical techniques, including X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), X-ray fluorescence spectroscopy (XRF), inductively coupled plasma optical emission spectroscopy (ICP-OES), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR), were employed to comprehensively characterize the geochemical processes, mineralogy, and organic matter environment of soil microaggregates. The findings revealed that soils near the steel works were acidified and strongly oxidized, with heavy metal contents, particularly Fe, significantly decreasing with increasing distance from the steel works (Fe content decreased from 27,516.2 mg/kg to 23,492.6 mg/kg). The pH of soils near the steel works was lower, while oxidation-reduction potential (ORP) and electrical conductivity were higher. XPS analysis indicated a higher content of reactive oxygen species (ROS) near the steel works and significantly lower soil organic matter content. The iron valence distribution showed spatial differences, with higher Fe2⁺ content on the surface of soil microaggregates near the steel works and Fe³⁺ dominating in areas farther away. These results suggest an evolutionary sequence of ZVI from Fe (0) oxidation to Fe(II) and then to Fe(III). The formation of dissipative structures in soil microaggregates due to ZVI contamination significantly affects soil physicochemical properties and the organic environment. This study provides valuable insights into the multifaceted impacts of industrial activities on soil ecosystems and offers a scientific basis for soil conservation and remediation strategies.
Structural and acoustic properties of urbanized landscapes adversely affect bird communities in a tropical environment
Authors: Matthew Dickson Anoibi , Osinubi Samuel Temidayo , Ivande Samuel Tertese , Iwajomo Soladoye B. , Ottosson Ulf 
Published: November 2024

IntroductionThe rural-urban gradient serves as a valuable context for investigating the impact of urbanization on biodiversity. While previous studies have demonstrated shifts in bird communities along this gradient, our understanding of the specific impacts of individual urban components such as man-made physical structures and anthropogenic noise along this gradient remains limited, and more so, in Afro-tropical environments.MethodEmploying the point count method, we recorded birds and also determined the levels of anthropogenic noise and physical structures, across fifteen sites along the rural-urban gradient on the Jos Plateau, Nigeria. We then investigated variations in bird communities along the urbanization gradient and assessed the influence of the two urban components -anthropogenic noise and physical structures, on bird populations.ResultsThere was a decline in bird abundance and species richness along the urbanization gradient. Similarly, species common to all the urbanization categories (species present at least at one point in rural, suburban, and urban) also exhibited a decrease in abundance. The suburban area showed a greater similarity in bird community composition to the urban area than the rural area. Notably, as the level of urban development increased, numerous bird species associated with undisturbed sites gradually vanished. Both anthropogenic noise and physical structures exhibited significant negative effects on bird abundance and species richness. Interestingly, we did not find evidence to suggest that the impact of anthropogenic noise was dependent on the level of physical structures. Anthropogenic noise had a significant negative relationship with bird abundance and species richness at all levels of physical structures.DiscussionWe provide evidence that bird abundance and species richness respond negatively to urbanization-related increase in anthropogenic noise and physical structures. That the impact of anthropogenic noise on birds was independent of physical structures suggests that birds in reserved areas, including urban green areas with fewer human activities may equally be affected by noise as are birds in human-dominated areas, if noise sources are near. Overall, our research underscores the detrimental consequences of anthropogenic habitat modification, particularly the alteration of structural and acoustic properties, and emphasizes the importance of preserving undisturbed habitats and implementing ecologically mindful urban planning strategies to safeguard bird communities in the Afro-tropics.
Causal effect of waist-to-hip ratio on non-alcoholic fatty liver disease: a mendelian randomization study
Authors: Wu Shihao , He Yuhong , Li Jiaxing , Wang Sijie 
Published: November 2024

ObjectiveThis study aimed to explore the potential causal association between waist-to-hip ratio (WHR) and the risk of non-alcoholic fatty liver disease (NAFLD) via the Mendelian randomization (MR) approach.MethodsGenetic variation data pertaining to WHR served as instrumental variables, while genome-wide association study data for NAFLD constituted the outcome event. Primarily, the random-effects inverse-variance weighted (IVW) method was utilized, supplemented by MR Egger, weighted median, simple mode, and weighted mode analyses. Sensitivity analysis entailed the “leave-one-out” approach, with the IVW results forming the foundational basis for this study.ResultsThis analysis included a total of 28 valid single nucleotide polymorphisms (SNPs). IVW analysis indicated an increased risk of NAFLD associated with WHR (OR = 1.61; 95% CI: 1.08–2.41; P = 0.02). Furthermore, MR-Egger regression analysis revealed the absence of horizontal pleiotropy among the included SNPs, albeit with some sample heterogeneity. Lastly, the “leave-one-out” sensitivity analysis demonstrated that no individual SNP significantly influenced the estimated causal association.ConclusionThis study furnishes indicative evidence of a causal link between waist-to-hip ratio and the risk of NAFLD occurrence.