bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empirical model for the prediction of lattice constants in 1:2 ordered perovskites
Authors: Wright Bryan , Phuong Jessica , McManus Sophie , Tolman Kevin , Ubic Rick 
Published: November 2024

AbstractProcessing–structure relationships are at the heart of materials science, and predictive tools are essential for modern technological industries insofar as structure dictates intrinsic properties; however, few theoretical models exist for cation‐ordered perovskites. In this work, a combination of data mining and solid‐state synthesis was employed to collect structural data of 1:2 ordered (triple) perovskites. Three compositions within the (Ba1 − xSrx)(Mg1/3Ta2/3)O3 system were synthesized using a conventional solid‐state mixed‐oxide method. X‐ray diffraction data showed evidence of long‐range 1:2 B‐site cation ordering for all compositions. Additional data for another 24 1:2 ordered compositions were mined from literature. Correlative models for the deviation in modified tolerance factor (Δt′) were derived for each system, and a general model which is capable of predicting the pseudocubic lattice constants of such perovskites based solely on published ionic‐radii data developed.
Darier disease: Current insights and challenges in pathogenesis and management
Authors: Ettinger Monika , Kimeswenger Susanne , Deli Isabella , Traxler Judith , Altrichter Sabine , Noack Petar , Wikstrom Jakob D. , Guenova Emmanuella , Hoetzenecker Wolfram 
Published: November 2024

AbstractDarier disease is a rare autosomal dominant genodermatosis caused by mutations in the ATP2A2 gene encoding for sarcoendoplasmic reticulum Ca2+ ATPase isoform 2. The skin disease is characterized by a chronic relapsing course with recurrent reddish‐brown keratotic papules and plaques located mainly in seborrhoeic areas. Due to chronic inflammation and epidermal barrier defects of the skin, patients often develop severe bacterial and viral superinfections. Therapeutic options are limited, mainly symptomatic and in most cases unsatisfactory in the long term. Patients are advised to avoid aggravating factors such as high temperature, high humidity, UV radiation and mechanical irritation. To prevent superinfection, antiseptics and periodic use of topical corticosteroids are fundamental in treatment. In case of bacterial and viral superinfection, systemic anti‐infective therapy is often necessary. Currently, the most effective treatment option for extensive and persistent skin lesions is systemic retinoids, which are thought to mainly target the epidermal compartment (e.g. by reducing hyperkeratosis). One hallmark of Darier disease patients is chronic skin inflammation. We and others have previously reported Th17 cells in the dermal infiltrate of inflamed Darier disease skin. Counteracting inflammation by blocking the IL‐23/IL‐17 axis improved skin manifestations in a small cohort of previously therapy‐resistant patients over 1 year. Furthermore, several other topical treatment options for mild disease as well as various ablative therapies and surgical excision have been proposed to be effective in some patients with hypertrophic skin lesions. This article aims to outline the pathogenesis, clinical features, diagnosis/differential diagnosis and available treatment modalities of Darier disease.
Accelerating the pace of elder justice policy to meet the needs of a growing aging population
Authors: Lees Haggerty Kristin , Stoeckle Rebecca Jackson , Campetti Randi , Froberg Ruthann , Ojelabi Olanike , Connolly M. T. , Epstein‐Lubow Gary , Mosqueda Laura , Greenlee Kathy , Tuboku‐Metzger Laini , Liao Junyue , Fulmer Terry 
Published: November 2024

AbstractPolicy measures designed to address elder abuse, neglect, and exploitation date back to decades, including the Older Americans Act of 1965. Over the years, various legislative actions have aimed to address elder mistreatment, culminating in the Elder Justice Act of 2010. Despite these efforts, policy changes lag behind need, and government funding appropriation is woefully inadequate. On November 29, 2023, the National Collaboratory to Address Elder Mistreatment convened 76 experts from research, clinical practice, policymaking, federal and state agencies, and national organizations to develop strategies for accelerating policy action to address elder mistreatment. Key themes from the convening included the need for a unified and stronger infrastructure and messaging, the importance of data‐driven policy and evidence‐informed prevention and intervention practices, and expanding strategic engagements. Participants emphasized the need for a holistic and long‐term approach, leveraging data to demonstrate outcomes, and building coalitions across related fields to address elder mistreatment. Action steps were identified for both national and state/local levels, focused on enhancing data‐informed elder mistreatment prevention, intervention, and response programs. The broad cross‐sector participation in the convening and the findings underscored the urgency of and potential for advancing elder justice policy. By leveraging existing initiatives, utilizing data emerging particularly in the past 5 years, building on decades of advocacy, and fostering new collaborations, there is a significant opportunity to improve prevention, intervention, and response to elder mistreatment.
Challenges for Antepartum Care of the Individual with Perinatal Substance Use: An Empirical Integrative Review of Novel Approaches to Improve Care
Authors: Narbey Lauren Taylor , Cline Alice Curtis 
Published: November 2024

IntroductionPerinatal substance use continues to rise across the United States presenting unique challenges to providing antepartum care. Polysubstance use, limited and late engagement in health care, co‐occurring mood disorders, and several social barriers are well documented. This review seeks to summarize these barriers and present novel approaches to caring for this high‐risk population.MethodsInclusion criteria for this study focused on peer‐reviewed articles that explicitly detailed a direct impact on the provision or receipt of antenatal care in the setting of substance use within the United States that were published in the last 5 years. PubMed and Web of Science were used to find applicable articles. Of the 156 articles found, 10 relevant articles were selected for the final empirical integrative review that entailed data evaluation using the Mixed Methods Appraisal Tool (MMAT) and thematic analysis.Results10 review articles met inclusion; 3 were qualitative, 6 were quantitative and nonrandomized, and one was quantitative descriptive. Six articles met MMAT quality criteria, and there were significant limitations in every article. Topics included opioid use disorder (n = 6), general substance use (n = 3), and tobacco use (n = 1). Themes included integrated models of prenatal care, colocated care, resource coordination, and peer support along with the role of the perinatal health care professional and consistent use of a substance use screening tool.DiscussionA comprehensive and multidisciplinary care model is necessary to meet the complex and urgent needs of individuals with perinatal substance use that not only meets recommendations for opioid maintenance therapy or substance use cessation but the important areas of accessibility and interpersonal support. Future research should focus on the development, implementation, and evaluation of new models of care for this vulnerable population.
CELS‐3D—Cutting edge light source for exciting fluorescence in microtome‐based 3D microscopy and targeted correlative microscopy
Authors: Denyshchenko Vladyslav , Evans Christopher , O'Neill Tiina , Krstev Jakub , Filipczak Emilia , O'Toole Silas , Lobaskin Vladimir , Scholz Dimitri 
Published: November 2024

AbstractWe discovered that the light entering a triangular ultramicrotome glass knife from the bottom exits the knife through its cutting edge, forming an oblique light sheet illumination suitable for imaging. We adopted this light sheet for side illumination of the sample blocks during sectioning on the ultramicrotome, for 3D imaging, and for targeting fluorescent features for confocal‐, electron‐ and correlative microscopy. In this paper, we present a working prototype named CELS‐3D (Cutting Edge Light Source, Three‐Dimensional), a microscope mounted on an ultramicrotome. We characterised CELS‐3D and applied it for 3D imaging of human liver spheroids with a diameter of approximately 500 μm. The structure of nuclei and tight junctions has been successfully reconstructed over the full spheroid volume. In contrast, a confocal microscope was unable to image spheroids to a depth of greater than 50 μm. CELS‐3D shows fluorescence during serial sectioning in an online mode; therefore, it can apply for targeting fluorescence structures for correlative microscopy. We successfully applied CELS‐3D for targeted correlative microscopy of human liver spheroids and C. elegans. The CELS‐3D can be utilised for less‐ and non‐transparent samples, which encompasses a range of applications, including operation biopsies, experimental organoids/spheroids, artificial cartilage, and bone, among others. The CELS‐3D can be effortlessly mounted on the top of any commercially available ultramicrotome, and its operation is straightforward and intuitive.
New Plant Extracts Exert Complementary Anti‐Hair Loss Properties in Human In Vitro and Ex Vivo Models
Authors: Bacqueville Daniel , Lévêque Marguerite , Mas Camille , Haure Marie‐José , Noustens Anaïs , Mengeaud Valérie , Carrère Sophie , Bessou‐Touya Sandrine , Duplan Hélène , Rizzi Nathalie Castex , Saurat Jean‐Hilaire 
Published: November 2024

ABSTRACTBackgroundHair loss is linked to dysfunction of the growth (anagen), regression (catagen) and rest (telogen) phases of the hair follicle (HF) cycle.AimsTo evaluate the effects of a Silybum marianum extract (SME), manganese PCA (MnPCA), and a Lespedeza capitata extract (LCE) on markers of hair growth and anchorage in human follicle dermal papilla cells (HFDPCs), and to investigate the ability of a topical serum containing these active ingredients to improve HF growth in an ex vivo human scalp skin model.MethodsIn HFDPCs, we assessed receptor tyrosine kinase phosphorylation and Wnt/β‐catenin pathway activation; quantified versican, vascular endothelial growth factor (VEGF) and Dickkopf‐1 (DDK1) secretion; and evaluated 5α‐reductase (5αR) activity. Using scalp skin biopsies from two female donors, we measured hair shaft elongation, analyzed hair matrix keratinocyte proliferation and apoptosis, and determined HF cycle stage and score.ResultsCompared to untreated HFDPCs, SME upregulated phosphorylation of growth factor receptors (EGFR:1.9 × and PDGFR: 2.8 ×) and their downstream effectors (ERK, GSK3, Akt, and STAT: 1.2–2.0 ×); MnPCA enhanced versican (33.0 ×) and VEGF (3.3 ×) secretion, and stimulated the Wnt/β‐catenin pathway (+80%); and LCE reduced DKK1 secretion (−72%) and 5αR activity (dihydrotestosterone/testosterone ratio: −60%). Compared to untreated scalp skin biopsies, the serum enhanced hair shaft elongation (+102%), and significantly prolonged the anagen phase by improving hair cycle scores and stimulating hair matrix keratinocyte proliferation (+58%).ConclusionsSME, MnPCA, and LCE displayed complementary anti‐hair loss properties. The serum combining these active ingredients may be useful in hair loss treatment.
Coping Measures for Hospital Nurses' Turnover: A Qualitative Meta‐Aggregation (2018–2023)
Authors: Zheng Qin , Liu Shihua , Zhang Yanyan 
Published: November 2024

ABSTRACTAimTo identify and synthesise the qualitative evidence that is available regarding reducing the turnover of hospital nurses from their own perspectives.DesignA qualitative systematic review using the meta‐aggregation design.Data SourcesQualitative studies either in English or in Chinese, dating from 2018 to 2023, were obtained from eight databases, including CINAHL, PubMed, Web of Science, Embase, Ovid, and Chinese National Knowledge Infrastructure (CNKI), Wanfang Database and the China Biomedical Database.MethodsStudies were screened using pre‐determined inclusion and exclusion criteria. Quality assessment was done using the Joanna Briggs Institute Critical Appraisal Checklist for Qualitative Research. The study was reported according to the Enhancing Transparency in Reporting the Synthesis of Qualitative Research (ENTREQ) guidelines.ResultsSixteen papers were included that explored nurses' perspectives on enhancing their retention or reducing staff turnover. We developed three synthesised findings and 12 categories from 64 identified findings, including (1) individual adjustment strategy: professional pride, self‐growth and psychological adjustment; (2) social support strategy: constructive workplace relationships, balancing work life and recognition of nursing and (3) organisational change strategy: embracing management and leadership, promote nursing professionalisation, workload management and support, flexible work patterns and opportunities, supporting personal career development and competitive salary.ConclusionThis review provides an in‐depth and meaningful understanding of nurses' own perceptions and suggestions for enhancing nursing turnover, which will call for a wide range of measures targeting the individual, social and organisational levels.Implications for Nursing ManagementThis study contributes important knowledge to help improve hospital nurse's turnover, which can provide evidence to support nurse managers, other stakeholders and policymakers in correspondingly developing effective measures to address nurse turnover.Patient or Public ContributionThere was no direct contribution from patient or caregiver to this study because the data of this study originated from published papers.
Private Equity and Financial Stability: Evidence from Failed‐Bank Resolution in the Crisis
Authors: JOHNSTON‐ROSS EMILY , MA SONG , PURI MANJU 
Published: November 2024

ABSTRACTThis paper investigates the role of private equity (PE) in failed‐bank resolutions after the 2008 financial crisis, using proprietary Federal Deposit Insurance Corporation failed‐bank acquisition data. PE investors made substantial investments in underperforming and riskier failed banks, particularly in geographies where local banks were also distressed, filling the gap created by a weak, undercapitalized banking sector. Using a quasi‐random empirical design based on detailed bidding information, we show that PE‐acquired banks performed better ex post, with positive real effects for the local economy. Overall, PE investors played a positive role in stabilizing the financial system through their involvement in failed‐bank resolution.
Alternaria ethzedia Causes Kadamba Leaf Spot in Punjab: A New Host Report
Authors: Baral Deewakar , Thapa Sukram , Lepcha Rodrick , Koshariya Ashok Kumar , Ali Sajeed 
Published: November 2024

ABSTRACTIn December 2023, Neolamarckia cadamba trees at Lovely Professional University, Punjab, India, exhibited a necrotic leaf spot disease affecting 20%–40% of their foliage, with similar symptoms observed in nearby farmer fields of Punjab. The disease manifested as concentric ring spots with yellow halos. Samples from three infected leaves of six trees were collected, and tissues from lesion margins were cultured. Six isolates (LPUAE1‐LPUAE6) were obtained and cultured on PDA medium, displaying greyish fungal colonies. The conidia were identified morphologically as belonging to the genus Alternaria spp. DNA analysis using ITS and ATPase region amplifications confirmed the isolates as Alternaria ethzedia, with sequences deposited in NCBI GenBank. Till now there is no report on diseases of kadamba caused by A. ethzedia and this first report indicates that further studies on leaf spot disease management are needed.
Integrated Control of Alternaria Blotch in Apple Orchards
Authors: Chauhan Praneet , Gupta Arvind Kumar , Sharma Jagan Nath , Sharma Monica 
Published: November 2024

ABSTRACTAn investigation of Alternaria blotch in apple orchards was conducted to evaluate the effectiveness of fungicides, plant extracts and bioagents against Alternaria mali through the development of integrated disease management strategies. Under pot conditions, potential combinations of fungicides, plant extracts and biocontrol agents for mitigating the disease were evaluated. Furthermore, polyhouse studies showed that bioagents such as Trichoderma viride, Bacillus subtilis and Pseudomonas fluorescens have disease control potential. Moreover, this research explored the impact of fungicides on the production of primary inoculum, highlighting the potential to impede conidial production by the pathogen. Over two cropping seasons, field assessments indicated the efficiency of integrated approaches in managing Alternaria blotch of apples. This study highlights the importance of reducing chemical inputs while ensuring successful disease management, offering important insights into a more sustainable approach to the management of diseases in apple orchards.
Special mechanism for monitoring recommendations in security institutions in Mexico
Authors: Gómez Cossio Sara María 
Published: November 2024

AbstractSince their inception, security institutions in Mexico have undergone significant transformations in their structure, organization, and responsibilities, which has influenced their role in ensuring public safety in the country. The configuration of the institution responsible for providing security in Mexico under military leadership not only deviates from the constitutional precepts to which it should adhere but also undermines the legal security of citizens regarding the enjoyment and full exercise of their human rights, due to acts prone to rights violations by such corporations, especially in the absence of a social proximity formation. This article focuses on the international perspective of human rights organizations about the security institutions in Mexico, considering the jurisprudence, recommendation, and cases in the Inter‐American Human Rights System. Multiple international organizations conclude that these security institutions have indicated a regression in human rights and require oversight by a regional international entity to ensure compliance with recommendations and the guarantee of a rule of law.
Comparative Study of Arctic Front Advance Pro and POLARx Cryoballoons for Linear Ablation of the Left Atrial Roof
Authors: Shigeta Takatoshi , Sagawa Yuichiro , Arai Hirofumi , Oda Atsuhito , Sudo Koji , Murata Kazuya , Okishige Kaoru , Kurabayashi Manabu , Goya Masahiko , Sasano Tetsuo , Yamauchi Yasuteru 
Published: November 2024

ABSTRACTBackgroundThe effectiveness of cryoballoon ablation (CBA) of the left atrial (LA) roof in addition to pulmonary vein isolation (PVI) using a novel cryoballoon catheter, POLARx, remains unclear.MethodsThis study compared the efficacy of LA roof line ablation and PVI using POLARx (Boston Scientific) or AFA‐Pro (Medtronic) in 100 patients with persistent atrial fibrillation. The right superior pulmonary vein (PV) anchoring and raise‐up techniques were consistently used for LA roof line ablation, and rapid right ventricular pacing was applied if the cryoballoon temperature did not reach −40°C.ResultsComplete conduction block at the LA roof could be obtained in all patients with POLARx and in 98.0% of patients with AFA‐Pro. Rapid right ventricular pacing was needed in 64.0% of patients with AFA‐Pro and in no patients with POLARx. During LA roof line ablation, the nadir cryoballoon temperature was significantly lower with POLARx than with AFA‐Pro (right: −54.2°C ± 4.4°C vs. −46.0°C ± 5.4°C; central: −56.8°C ± 4.4°C vs. −45.7°C ± 4.8°C; left: −56.1°C ± 4.3°C vs. −46.1°C ± 5.7°C), and the cryoballoon temperature reached −40°C earlier with POLARx than with AFA‐Pro (right: 30.8 ± 7.4 s vs. 74.1 ± 37.7 s; central: 28.2 ± 5.2 s vs. 62.9 ± 30.9 s; left: 29.8 ± 5.8 s vs. 69.6 ± 40.7 s).ConclusionThe nadir cryoballoon temperature with POLARx was approximately 10°C lower than with AFA‐Pro, consistently dropping below −40°C during LA roof line CBA. Thus, a complete conduction block of the LA roof line can be easily accomplished using right superior PV anchoring and the raise‐up techniques without the need for rapid right ventricular pacing with POLARx.
Manipulation cases in free will and moral responsibility, part 2: Manipulator‐focused responses
Authors: De Marco Gabriel , Cyr Taylor W. 
Published: November 2024

AbstractIn this paper—Part 2 of 3—we discuss one of the two main types of soft‐line responses to manipulation cases, which we refer to as manipulator‐focused views. Manipulator‐focused views hold, roughly, that the reason that Victim lacks responsibility (or lacks full responsibility) is because of the way the action is related to the Manipulator. First, we introduce these views generally, and then we survey some detailed versions of such views. We then introduce cases of natural forces, often taken to be a problem for such approaches in general, followed by a discussion of various sorts of cases—accidental results, lucky manipulators, and parallel cases—that present challenges for some of the detailed versions of such views. We conclude with some thoughts about the prospects for manipulator‐focused views going forward.
Early childhood body mass index growth and school readiness: A longitudinal cohort study
Authors: Li Xuedi , Kahane Alyssa , Keown‐Stoneman Charles D. G. , Omand Jessica A. , Borkhoff Cornelia M. , Lebovic Gerald , Maguire Jonathon L. , Mamdani Muhammad , Parkin Patricia C. , Simpson Janis Randall , Tremblay Mark S. , Vanderloo Leigh M. , Duku Eric , Reid‐Westoby Caroline , Janus Magdalena , Birken Catherine S. ,   the TARGet Kids! Collaboration
Published: November 2024

AbstractBackgroundChild growth influences future health and learning. School readiness refers to a child's ability to meet developmental expectations at school entry. The association of early growth rate and patterns with school readiness remains unknown.ObjectiveTo determine the association of child body mass index (BMI) growth with school readiness in a cohort of young children.MethodsA prospective cohort study (2015–2022) was conducted in children 0–6 years enrolled in the TARGet Kids! research network in Toronto, Canada. Two analytical approaches were used to measure growth using child weight and height/length data between 0 and 4 years: (i) age‐ and sex‐standardised BMI (zBMI) growth rate per year using a piecewise linear model; and (ii) distinct zBMI trajectories using latent class mixed models. School readiness (4–6 years) was measured using teacher‐completed Early Development Instrument (EDI). Robust Poisson models and marginal linear models using generalised estimating equations were used adjusting for confounders identified a priori.ResultsIn this study of 1077 children (mean age at EDI completion: 4.8 years; 52.6% male) with 6415 zBMI measurements, mean growth rate was 0.65 zBMI units/year (0–2 years) and −0.11 zBMI units/year (2–4 years). Two distinct zBMI trajectories were identified: the stable trajectory and the catch‐up trajectory. There was insufficient evidence that zBMI growth rates (risk ratio 1.10, 95% confidence interval 0.78, 1.55 for 0–2 years; risk ratio 0.71, 95% confidence interval 0.32, 1.57 for 2–4 years) or trajectories (risk ratio 1.05, 95% confidence interval 0.82, 1.35, catch‐up trajectory vs. stable trajectory) were associated with school readiness.ConclusionsNo association was found between BMI growth and school readiness. School readiness may be more impacted by factors directly related to obesity or adiposity at the time of EDI measurement rather than growth.