bluuebunny/crossref_metadata_2025_split huggingface dataset:
Migration of the femoral stem after impaction bone grafting
Authors: van Doorn W. J. , ten Have B. L. E. F. , van Biezen F. C. , Hop W. C. J. , Ginai A. Z. , Verhaar J. A. N. 
Published: February 2018

We report the initial results of an ongoing randomised, prospective study on migration of the Exeter and Elite Plus femoral stems after impaction allografting, as measured by radiostereometry. Clinically, the impaction technique gave good results for both stems. The mean subsidence in the first year was 1.30 mm and 0.20 mm for the Exeter and the Elite Plus stems, respectively. In the second year, the Exeter stem continued to subside further by a mean of 0.42 mm, while the Elite Plus stem did not do so. Subsidence of the Exeter stem correlated with deficiency of bone stock as graded on the Gustilo and Pasternak scale. This correlation was not found for the Elite Plus stem. None of the other parameters which were studied predisposed to subsidence. There was no significant association between the amount of subsidence and the radiological appearance of the graft for either stem. Our findings do not support the theory that radial compression, due to subsidence of the Exeter stem, is the essential stimulus for remodelling in impaction allografting.
The effect of rotational malunion of the radius and the ulna on supination and pronation
Authors: Dumont C. E. , Thalmann R. , Macy J. C. 
Published: February 2018

We have assessed the influence of isolated and combined rotational malunion of the radius and ulna on the rotation of the forearm. Osteotomies were made in both the radius and the ulna at the mid-diaphyseal level of five cadaver forearms and stabilised with intramedullary metal implants. Malunion about the axis of the respective forearm bone was produced at intervals of 10°. The ranges of pronation and supination were recorded by a potentiometer under computer control. We examined rotational malunions of 10° to 80° of either the radius or ulna alone and combined rotational malunions of 20° to 60° of both the radius and ulna. Malunion of the ulna in supination had little effect on rotation of the forearm. Malunion of either the radius or of the ulna in pronation gave a moderate reduction of rotation of the forearm. By contrast, malunion of the radius in supination markedly reduced rotation of the forearm, especially with malunion greater than 60°. Combined rotational malunion produced contrasting results. A combination of rotational malunion of the radius and ulna in the same direction had an effect similar to that of an isolated malunion of the radius. A combination in the opposite direction gave the largest limitation of the range of movement. Clinically, rotational malunion may be isolated or part of a complex angular/rotational deformity and rotational malunion may lead to marked impairment of rotation of the forearm. A reproducible method for assessing rotational malunion is therefore needed.
Tissue-engineered cartilage and bone using stem cells from human infrapatellar fat pads
Authors: Dragoo J. L. , Samimi B. , Zhu M. , Hame S. L. , Thomas B. J. , Lieberman J. R. , Hedrick M. H. , Benhaim P. 
Published: February 2018

Multipotential processed lipoaspirate (PLA) cells extracted from five human infrapatellar fat pads and embedded into fibrin glue nodules, were induced into the chondrogenic phenotype using chondrogenic media. The remaining cells were placed in osteogenic media and were transfected with an adenovirus carrying the cDNA for bone morphogenetic protein-2 (BMP-2). We evaluated the tissue-engineered cartilage and bone using in vitro techniques and by placing cells into the hind legs of five severe combined immunodeficient mice. After six weeks, radiological and histological analysis indicated that the PLA cells induced into the chondrogenic phenotype had the histological appearance of hyaline cartilage. Cells transfected with the BMP-2 gene media produced abundant bone, which was beginning to establish a marrow cavity. Tissue-engineered cartilage and bone from infrapatellar fat pads may prove to be useful for the treatment of osteochondral defects.
Development and testing of a reduced WOMAC function scale
Authors: Whitehouse S. L. , Lingard E. A. , Katz J. N. , Learmonth I. D. 
Published: February 2018

We used prospective data from 862 total knee and 716 total hip replacements three years after surgery in order to derive and validate a reduced Western Ontario and McMasters University Osteoarthritis Index (WOMAC) function scale. The reduced scale was derived using the advice of clinical experts as well as analysis of data. The scale was tested for validity, reliability and responsiveness. Items which were retained included: ascending stairs, rising from sitting, walking on the flat, getting in or out of a car, putting on socks, rising from bed, and sitting. The reduced and full scales had comparable, moderate correlations with other measures of function, confirming convergent validity. Cronbach’s alpha was high (α > 0.85) with the reduced scale confirming reliability. Responsiveness was greater for the reduced scale (full = 1.4, reduced = 1.6). This reduced version of the WOMAC function scale provides a practical, valid, reliable and responsive alternative to the full function scale for use after total joint replacement. Further work is needed to demonstrate its wider applicability.
Secondary resurfacing of the patella for persistent anterior knee pain after primary knee arthroplasty
Authors: Muoneke H. E. , Khan A. M. , Giannikas K. A. , Hägglund E. , Dunningham T. H. 
Published: February 2018

Out of a total of 623 patients who, over a ten-year period, underwent primary total knee replacement (TKR) without patellar resurfacing, 20 underwent secondary resurfacing for chronic anterior knee pain. They were evaluated pre- and postoperatively using the clinical and radiological American Knee Society score. The mean follow-up was 36.1 months (12 to 104). The mean knee score improved from 46.7 to 62.2 points and the mean functional score from 44.7 to 52.2 points. Only 44.4% of the patients, however, reported some improvement; the remainder reported no change or deterioration. The radiographic alignment of the TKR did not influence the outcome of secondary resurfacing of the patella. Complications were noted in six of the 20 patients including fracture and instability of the patella and loss of movement. Anterior knee pain after TKR remains difficult to manage. Secondary resurfacing of the patella is not advocated in all patients since it may increase patient dissatisfaction and hasten revision.
Levels of metal ions after small- and large-diameter metal-on-metal hip arthroplasty
Authors: Clarke M. T. , Lee P. T. H. , Arora A. , Villar R. N. 
Published: February 2018

Metal-on-metal (MOM) bearings for hip arthroplasty are increasing in popularity. Concern remains, however, regarding the potential toxicological effects of the metal ions which these bearings release. The serum levels of cobalt and chromium in 22 patients who had undergone MOM resurfacing arthroplasty were compared with a matched group of 22 patients who had undergone 28 mm MOM total hip arthroplasty (THA). At a median of 16 months (7 to 56) after resurfacing arthroplasty, we found the median serum levels of cobalt and chromium to be 38 nmol/l (14 to 44) and 53 nmol/l (23 to 165) respectively. These were significantly greater than the levels after 28 mm MOM THA which were 22 nmol/l (15 to 87, p = 0.021) and 19 nmol/l (2 to 58, p < 0.001) respectively. Since the upper limit for normal patients without implants is typically 5 nmol/l, both groups had significantly raised levels of metal ions. MOM bearings of large diameter, however, result in a greater systemic exposure of cobalt and chromium ions than bearings of small diameter. This may be of relevance for potential long-term side-effects. It is not known to what extent this difference is due to corrosion of the surfaces of the component or of the wear particles produced.
Conversion of biarticular to monoarticular muscles as a component of multilevel surgery in spastic diplegia
Authors: Metaxiotis D. , Wolf S. , Doederlein L. 
Published: February 2018

We treated 20 children (40 limbs) with diplegic cerebral palsy who could walk by multilevel soft tissue operative procedures including conversion of the biarticular semitendinosus and gastrocnemius to monoarticular muscles. The mean age at surgery was 11.5 years (5.6 to 17.0). All patients underwent clinical and radiological examination and three-dimensional instrumented gait analysis before and at a mean of 3.1 years (2.0 to 4.5) after surgery. The passive range of movement at the ankle, knee and hip showed improvement at follow-up. Kinematic parameters indicated a reduced pelvic range of movement and improvement of extension of the knee in single stance after operation (p < 0.0001). However, postoperative back-kneeing was detected in five of the 40 limbs. The kinetic studies showed that the power of the hamstrings and plantar flexors of the ankle was maintained while the maximum knee extensor moment during stance was reduced. The elimination of knee flexor activity of semitendinosus and gastrocnemius combined with transfer of distal rectus femoris led to an improvement in gait as confirmed by gait analysis.
The prognosis following acute primary glenohumeral dislocation
Authors: te Slaa R. L. , Wijffels M. P. J. M. , Brand R. , Marti R. K. 
Published: February 2018

We have studied 105 patients with 107 acute, primary, dislocations of the glenohumeral joint seen between January 1, 1991 and July 1, 1994. The mean time of follow-up was 71 months (46 to 91). In 34% the injury occurred during a sports activity and in 28% at home. The bias toward sport was even greater in patients less than 40 years of age, and in men. In patients older than 40 years of age, and in women, the dislocation occurred more often at home. The overall probability of recurrence within four years was 26%. Age was the most significant prognostic factor in recurrence which took place in 64% of patients less than 20 years of age and in 6% of those older than 40 years. Statistically, there was no difference between the rates of recurrence in patients who were active in sport and those who were not. The mean Rowe score for the whole group was 87 (15 to 100). Associated fractures were found in 20 patients (19%) and nerve injuries in 22 (21%). None of those in whom a fracture of the greater tuberosity was seen subsequently suffered a recurrent dislocation. At follow-up we found that 36 patients (34%) had not returned to their former employment but in only 2% was this owing to the injured shoulder.
Concomitant tumour resistance in patients with osteosarcoma
Authors: Kaya M. , Wada T. , Nagoya S. , Kawaguchi S. , Isu K. , Yamashita T. 
Published: February 2018

Concomitant tumour resistance (CTR) is a unique phenomenon in which animals harbouring large primary tumours are resistant to the growth of smaller metastatic tumours by systemic angiogenic suppression. To examine this clinically, in ten patients with osteosarcoma, we investigated the effects of removal of the primary tumour on the development of pulmonary metastases, the systemic angiogenesis-inducing ability and the serum levels of several angiogenesis modulators. We found that removal of the primary tumour significantly elevated systemic angiogenesis-inducing ability in five patients who had post-operative recurrence of the tumour. Post-operative elevation of the angiogenesis-induced ability was suppressed by the addition of an angiogenic inhibitor, endostatin. Also, primary removal of the tumour decreased the serum levels of vascular endothelial growth factor and endostatin. These findings suggest, for the first time, the presence of CTR in patients with osteosarcoma for whom postoperative antiangiogenic therapy may be used to prevent the post-operative progression of micrometastases.
Wear debris from hip or knee replacements causes chromosomal damage in human cells in tissue culture
Authors: Daley B. , Doherty A. T. , Fairman B. , Case C. P. 
Published: February 2018

Wear debris was extracted from 21 worn hip and knee replacements. Its mutagenic effects were tested on human cells in tissue culture using the micronucleus assay and fluorescent in situ hybridisation. The extracted wear debris increased the level of micronuclei in a linear dose-dependent manner but with a tenfold difference between samples. The concentration of titanium +/− vanadium and aluminium within the wear debris was linearly related both to the level of centromere-positive micronuclei in tissue culture, indicating an aneuploid event, and to the level of aneuploidy in vivo in peripheral blood lymphocytes. The concentration of cobalt and chromium +/− nickel and molybdenum in the wear debris correlated with the total index of micronuclei in tissue culture, both centromere-positive and centromere-negative i.e. both chromosomal breakage and aneuploidy events. The results show that wear debris can damage chromosomes in a dose-dependent manner which is specific to the type of metal. The results from studies in vitro correlate with those in vivo and suggest that the wear debris from a worn implant is at least partly responsible for the chromosomal damage which is seen in vivo.
The effect of extracorporeal shock waves on a rat model of injury to tendo Achillis
Authors: Orhan Z. , Ozturan K. , Guven A. , Cam K. 
Published: February 2018

The effects of extracorporeal shock waves (ESWT) on tendon healing were assessed by observing histological and biomechanical parameters in a rat model of injury to the tendo Achillis. The injury was created by inserting an 18-G needle through tendo Achillis in 48 adult Wistar albino rats. The animals were divided into three groups. The first group received radiation only after the operation. The second received no shock waves and the third had 500 15 KV shocks on the second post-operative day. All the rats were killed on the 21st day after surgery. Histopathological analysis showed an increase in the number of capillaries and less formation of adhesions in the study group compared with the control group (p = 0.03). A significantly greater force was required to rupture the tendon in the study group (p = 0.028). Our findings suggest a basis for clinical trials using ESWT.
Severity of hip dysplasia and loosening of the socket in cemented total hip replacement
Authors: Chougle A. , Hemmady M. V. , Hodgkinson J. P. 
Published: February 2018

We have assessed the long-term results of 292 cemented total hip replacements which were performed for developmental dysplasia of the hip in 206 patients. The mean age of the patients at operation was 42.6 years (15.9 to 79.5) and most (202) were women. The severity of dysplasia was graded according to both the Crowe and the Hartofilakidis classifications. A 22.25-mm Charnley head was always used and the acetabular components were inserted with cement into the true acetabulum. Bone grafting of the acetabulum, using the patient’s own femoral head, was performed on 48 occasions. At a mean follow-up of 15.7 years (2.2 to 31.2) the overall survival of the acetabular component was 78%. The main cause of revision was aseptic loosening (88.3%). The rate of survival at 20 years based on the Hartofilakidis classification was 76% in the dysplastic, 55% in the low-dislocation and 12% in the high-dislocation groups and on the Crowe classification, 72.7% for group I, 70.7% for group II, 36.7% for group III and 15.6% for group IV. There was no statistical correlation between bone grafting of the acetabulum and survival of the acetabular component. This study has shown a higher rate of failure of the acetabular component with increasing severity of hip dysplasia.
Spine–hip relations in patients with hip osteoarthritis
Authors: Rivière Charles , Lazic Stefan , Dagneaux Louis , Van Der Straeten Catherine , Cobb Justin , Muirhead-Allwood Sarah 
Published: February 2018

Patients with hip osteoarthritis often have an abnormal spine-hip relation (SHR), meaning the presence of a clinically deleterious spine-hip and/or hip-spine syndrome. Definition of the individual SHR is ideally done using the EOS® imaging system or, if not available, with conventional lumbopelvic lateral radiographs. By pre-operatively screening patients with abnormal SHR, it is possible to refine total hip replacement (THR) surgical planning, which may improve outcomes. An important component of the concept of kinematically aligned total hip arthroplasty (KA THA) consists of defining the optimal acetabular cup design and orientation based on the assessment of an individual’s SHR, and use of the transverse acetabular ligament to adjust the cup positioning. The Bordeaux classification might advance the understanding of SHR and hopefully help improve THR outcomes. Cite this article: EFORT Open Rev 2018;3:39-44. DOI: 10.1302/2058-5241.3.170020
Análisis multivariado para segmentación de clientes basada en RFM
Authors: Cuadros López Álvaro Julio , Gonzales Caicedo Caterine , Jiménez Oviedo Paola Cristina 
Published: February 2018

Contexto: Para construir una gestión exitosa de relaciones con los clientes, las empresas deben comenzar con la identificación del verdadero valor de los clientes ya que esto proporciona información básica para implementar estrategias de marketing más dirigidas y personalizadas. El análisis RFM, un método clásico de análisis, permite mediante tres parámetros de evaluación, analizar el comportamiento de los clientes y establecer segmentos. La adición de un nuevo parámetro en la metodología tradicional es una oportunidad para refinar los posibles resultados de una segmentación de clientes, pues no sólo proporciona un nuevo elemento de evaluación para identificar los clientes más valiosos, sino que permite diferenciar y conocer aún mejor a los clientes.Método: La propuesta metodológica que se incluye en este artículo permite establecer segmentos de clientes utilizando un método RFM extendido con nuevas variables, seleccionadas mediante análisis multivariados.Resultados: La propuesta fue aplicada en una empresa en la que se probaron variables, como ganancia, porcentaje de ganancia y días de vencimiento de facturación, y se logró establecer una segmentación de clientes más detallada que el RFM clásico. Conclusiones: El análisis RFM es un método de amplio uso en la industria por su fácil comprensión y aplicabilidad. Este método puede ser mejorado con el uso de procedimientos estadísticos y nuevas variables, lo que permitirá contar con información más profunda sobre el comportamiento de los clientes y facilitará el diseño de estrategias específicas de marketing.
Performa Peningkatan Lemak Dan Asam Lemak Linoleat Dari Daphnia Sp. Dengan Menggunakan Fermentasi Kotoran Burung Puyuh, Roti Afkir, Dan Ampas Tahu
Authors: Anwar Syaiful , Hutabarat Johannes , Herawati Vivi Endar 
Published: February 2018

Daphnia sp. was natural feed which could adequate the needs of fish fry growth. Fats and fatty acids was main factor which very influenced the success of reproduction and live for hatched larva fish. Fats had important role as the main source. The lack of essencial fatty acid could impact the decrease of fish growth and reproduction. The purpose of this research were to found out the best treatments and the effect of fermented quail feces, bread waste, and tofu waste towards the growth, and increased fats and linoleic fatty acid from Daphnia sp.. The methods of this research was used experimental method and complete randomize design with 4 treatments and 3 repetitions, with density of 100 ind./litre. The treatments which used on this research were treatment A (50% bread waste, 50% tofu waste, and 0% quail feces), treatment B (25% bread waste, 50% tofu waste, and 25% quail feces), treatment C (50% bread waste, 25% tofu waste, and 25% quail feces), and treatment C (25% bread waste, 25% tofu waste, and 50% quail feces) with total combination amount of 200 grams/litre. The data that observed were population of Daphnia sp., fatty acid value, and linoleic fatty acid value.The result of this research showed that Daphnia sp. growth population was valued 502,22 ind/ml – 1949,44 ind/ml, whereas the increasing of fat value from 6,26% became 8,15% and linoleic fatty acid from 0,91% become 6,14%. Acording to the research result could be concluded that the additition of fermented quail feces, and tofu waste gave differences towards the growth, with the fat value increased of Daphnia sp. was 1,89% and linoleic fatty acid was 5,23% and the best treatment for growth and linoleic fatty acid value was the treatment C (50% bread waste, 25% tofu waste, and 25% quail feces) and treatment A (50% bread waste, 50% tofu waste, and 0% quail feces) for the fat value of Daphnia sp. Keyword: Daphnia sp.; Fats; Linoleic Fatty Acid; Fermentation
KOMPOSISI PENYUSUN TERUMBU KARANG TEPI (FRINGING REEF) DI PULAU MANDANGIN KABUPATEN SAMPANG, MADURA The Composition of Fringing Reef Formation in Pulau Mandangin, Sampang Province, Madura
Authors: Guntur Guntur , Arifin Samsul , Luthfi Oktiyas Muzaky 
Published: February 2018

ABSTRAK Terumbu karang tepi di Pulau Mandangin tersusun substrat biotik dan abiotik dengan kedalaman tidak lebih dari 40 m. Pulau Mandangin adalah pulau kecil yang memiliki komposisi substrat dasar seperti terumbu karang dan perairannya yaitu zona leeward dan zona windward. Zona leeward adalah sisi yang membelakangi arah datangnya angin, sedangkan zona windward adalah sisi yang menghadap arah datangnya angin. Tujuan dari penelitian ini adalah untuk mengetahui komposisi penyusun terumbu karang tepi (fringing reef) dan mengetahui perbedaan komposisi penyusun terumbu karang tepi (fringing reef) antara zona leeward dan zona windward di Pulau Mandangin. Metode yang digunakan adalah Line Intercept Transect (LIT) secara vertikal, LIT dimulai dari surut terendah sampai daerah reef slope dan dilakukan pencatatan semua jenis substrat yang dibawah garis transek. Hasil penelitian menunjukkan zona fringing reef yang mengelilingi Pulau Mandangin tersusun atas substrat rubble, sand, alga, rock, dead coral, dead coral with algae, sponge, coral massive dan coral submassive. Zona leeward lebih bervariasi dari zona windward dalam susunan fringing reef. Hal ini karena angin yang terjadi di zona windward lebih besar dari zona leeward, sehingga substrat di zona windward hanya rubble dan sand. Kata kunci: Fringing reef, zona windward, zona leeward, substrat, Pulau Mandangin ABSTRACT Fringing reef in Mandangin Island comprises of biotic and abiotic substrates in depth not more than 40 m. Mandangin Island is a small island with base substrate composition mostly involving coral reef. The waters include leeward and windward zones. Leeward zone is paralleling with wind incoming direction, whereas windward zone is facing on wind incoming direction. The objective of research is to understand the composition that constitutes fringing reef and to recognize different constitutive composition of fringing reef at leeward zone and windward zone in Mandangin Island. Method of research is Line Intercept Transect (LIT) that is applied vertically. LIT starts from the lowest ebb toward the reef slope zone, and it involves registering all substrate types below transect line. Result of research indicates that fringing zone surrounding Mandangin Island consists of various substrates such as rubble, sand, alga, rock, dead coral, dead coral with algae, sponge, coral massive and coral sub-massive. Leeward zone is more diversified in fringing reef composition than windward zone. It is evident because wind occurrence at windward zone is higher than at leeward zone, and thus, substrates at windward zone include only rubble and sand. Keywords: Fringing reef, windward zone, leeward zone, substrates, Mandangin Island