bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of Helicobacter pylori on the presence of Barrett's esophagus in Azerbaijan, a high-prevalence area of infection
Authors: Aghayeva S , Mara K C , Katzka D A 
Published: June 2019

SUMMARY
There is a strong evidence that Helicobacter pylori infection is inversely associated with Barrett's esophagus. In a high-prevalence region of H. pylori, low rates of esophageal cancer and its precursor BE may indicate its preventive effect. The aim of this study is to determine the impact of H. pylori on characteristics of Barrett's esophagus.
A total of 3317 outpatient upper endoscopy reports from 2013 to 2015 from an urban center in Azerbaijan from all patients with dyspepsia were retrospectively analyzed for patients with Barrett's esophagus. This was matched in a 1:2 ratio to age and gender matched control patients without Barrett's esophagus. The prevalence of H. pylori on Barrett's esophagus and the randomly selected control group were compared.
There were 83 patients with BE and 167 control group cases. Biopsy-proven BE was diagnosed in 83 patients: 39 (47%) females, with mean age 43.1 ± 13.3 years. Of these, 13 (15.7%) had long segment and 70 (84.3%) had short segment Barrett's esophagus. A control group included 167 patients: 78 (46.7%) females, with mean age (45.8 ± 13.9). All patients were Caucasians. The rates of gastric inflammation, the presence of atrophy, and intestinal metaplasia in gastric specimens did not differ in patients versus controls. The prevalence of H. pylori was determined as 63.2% in male and 61.5 in female groups (odd ratio (OR) = 0.99 95%CI 0.97, 1.01; P = 0.22). Inflammation of gastric mucosa was strongly associated with the infection (67% vs. 33%; OR = 4.46 95% CI: 2.01, 9.92, P &lt; 0.001). Atrophy was noted in majority of H. pylori-positive cases (OR = 1.43, 95% CI: 0.36, 5.65; P = 0.61). Gastric intestinal metaplasia was observed in 55.6% of H. pylori-positive patients and in 44.4% of negative individuals (OR = 0.74, 95% CI: 0.28, 1.94; P = 0.54). There was not a significant difference in the prevalence of HP in BE and control groups; 63.9% were positive for infection in BE cases and 61.7% of controls (OR = 1.10, 95% CI: 0.64, 1.90; P = 0.74). We found that neither presence of erosive esophagitis, length of BE nor dysplasia (45.5% of H. pylori-positive group, whereas 54.5%) was associated with the presence of the H. pylori infection (Table 1).
In a predominantly Caucasian nation with a high prevalence of H. pylori gastritis, the presence of H. pylori was not inversely associated with the presence of Barrett's esophagus. These data challenge the mechanistic implications of this association.
Loss to follow-up after food impaction among patients with and without eosinophilic esophagitis
Authors: Chang Joy W , Olson Samuel , Kim Ju Young , Dolan Russell , Greenson Joel , Sanders Georgiana , Rubenstein Joel H 
Published: June 2019

SUMMARY
Symptoms of esophageal dysfunction such as food impaction are consistent with, but not diagnostic for eosinophilic esophagitis (EoE) without obtaining histology. We conducted a retrospective study to characterize patients with food impaction at a tertiary center. We hypothesized that many patients with food impaction may be lost to follow-up and that many have features suggestive of EoE. Adult patients presenting to the emergency department with esophageal food impaction were identified from an endoscopic database. Electronic medical records were manually abstracted. We examined associations between demographics, comorbid conditions, and follow-up with biopsy findings. Of 220 patients who presented to the emergency department for food impaction, 74.1% were men. Adequate follow-up was not documented in 120 (54.5%). Those lost to follow-up did not differ significantly by gender, age at symptom onset, or distance from hospital compared to those with follow-up. Esophageal biopsies were obtained in 158 (71.8%), and those with ≥15 eos/HPF were more likely to be lost to follow-up than those with &lt;15 eos/HPF (52.8% vs. 34.8%, P &lt; 0.05). Of those never biopsied, 79.0% were lost to follow-up and had intermediate proportions of males, food allergy, and asthma when compared to those with and without eosinophilic inflammation. Patients with food impaction commonly have EoE but are often lost to follow-up. Among those never biopsied, demographic and clinical features suggest that many may have undiagnosed EoE. Strategies for increasing use of biopsies in patients with food impaction and improving follow-up are needed to diagnose and manage EoE.
Air embolization of a left ventricular assist device in a child: an unusual case of a tension pneumothorax resulting in a fatal complication
Authors: Jaworski Radoslaw , Kansy Andrzej , Maruszewski Bohdan 
Published: June 2019

Abstract
Our goal was to describe a fatal air embolization that probably occurred through an inflow cannula implantation site as a result of a tension pneumothorax in a child with a left ventricular assist device. This is the first case that highlights the possibility of a left ventricular assist device air embolism in a child with a pneumothorax, especially a tension pneumothorax. The risk of air embolism increases with positive pressure in the pleural and pericardial cavities.
Cognitive Rehabilitation and Exposure/Sorting Therapy for Late-Life Hoarding: Effects on Neuropsychological Performance
Authors: Ayers Catherine R , Davidson Eliza J , Dozier Mary E , Twamley Elizabeth W 
Published: June 2019

Abstract

Objectives
Hoarding disorder (HD) is characterized by urges to save items, difficulty discarding possessions, and excessive clutter and has been associated with executive functioning deficits. A randomized controlled trial comparing Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) with a care management control condition demonstrated the efficacy of CREST in reducing hoarding symptoms in older adults. The purpose of the current study was to assess whether CREST may also lead to improved executive functioning.

Method
All participants were administered a neurocognitive battery at baseline and posttreatment. Linear mixed models with random intercepts were used to evaluate change in global neuropsychological functioning as well as change in individual executive functioning variables.

Results
There was no significant group by time interaction for the Global Deficit score; however, there were significant group by time interactions on two of the executive functioning variables examined, such that participants in the CREST condition demonstrated significant improvement in cognitive flexibility and inhibition over time compared with the participants in the care management condition.

Discussion
Our initial findings support the notion that CREST may be able to improve task switching, an important component of executive functioning, in older adults with HD.
Guidelines for defining the use of electricity in marine electrotrawling
Authors: Soetaert Maarten , Boute Pim G , Beaumont William R C 
Published: June 2019

Abstract
Electricity can be used to facilitate fish and invertebrate capture in both marine and freshwater environments. In freshwaters, electrofishing is largely used for research or management purposes. In marine environments electrofishing is principally used in the form of electrotrawling for the commercial capture of fishes and benthic invertebrates, in particular common sole (Solea solea L.), brown shrimp (Crangon crangon L.), and razor clams (Ensis spp.). The terminology and definitions used to describe the electrical stimulus characteristics and experimental set-ups have, so far, been diverse and incomplete, hampering constructive discussion and comparison of electrofishing studies. This paper aims to (i) harmonize existing terminology, abbreviations, and symbols, (ii) offer best practice recommendations for publishing results, and (iii) provide a concise and comprehensible reference work for people unfamiliar with this topic. By incorporating common practice in marine electric pulse trawling terminology and related freshwater electrofishing studies, based on existing terms where possible, we provide a framework for future studies. The suggested guideline is recommended by the ICES Working Group on Electrical Trawling as a constructive approach to improved communication standards in electrofishing and electrical pulse stimulation research and publications.
Multiple-criteria cash-management policies with particular liquidity terms
Authors: Salas-Molina Francisco , Pla-Santamaria David , Garcia-Bernabeu Ana , Mayor-Vitoria Fernando 
Published: June 2019

Abstract
Eliciting policies for cash management systems with multiple assets is by no means straightforward. Both the particular relationship between alternative assets and time delays from control decisions to availability of cash introduce additional difficulties. Here we propose a cash management model to derive short-term finance policies when considering multiple assets with different expected returns and particular liquidity terms for each alternative asset. In order to deal with the inherent uncertainty about the near future introduced by cash flows, we use forecasts as a key input to the model. We express uncertainty as lack of predictive accuracy and we derive a deterministic equivalent problem that depends on forecasting errors and preferences of cash managers. Since the assessment of the quality of forecasts is recommended, we describe a method to evaluate the impact of predictive accuracy in cash management policies. We illustrate this method through several numerical examples.
Associations between residual feed intake and apparent nutrient digestibility, in vitro methane-producing activity, and volatile fatty acid concentrations in growing beef cattle1
Authors: Johnson Jocelyn R , Carstens Gordon E , Krueger Wimberly K , Lancaster Phillip A , Brown Erin G , Tedeschi Luis O , Anderson Robin C , Johnson Kristen A , Brosh Arieh 
Published: June 2019

Abstract
The objectives of this study were to examine the relationship between residual feed intake (RFI) and DM and nutrient digestibility, in vitro methane production, and volatile fatty acid (VFA) concentrations in growing beef cattle. Residual feed intake was measured in growing Santa Gertrudis steers (Study 1; n = 57; initial BW = 291.1 ± 33.8 kg) and Brangus heifers (Study 2; n = 468; initial BW = 271.4 ± 26.1 kg) fed a high-roughage-based diet (ME = 2.1 Mcal/kg DM) for 70 d in a Calan-gate feeding barn. Animals were ranked by RFI based on performance and feed intake measured from day 0 to 70 (Study 1) or day 56 (Study 2) of the trial, and 20 animals with the lowest and highest RFI were identified for subsequent collections of fecal and feed refusal samples for DM and nutrient digestibility analysis. In Study 2, rumen fluid and feces were collected for in vitro methane-producing activity (MPA) and VFA analysis in trials 2, 3, and 4. Residual feed intake classification did not affect BW or BW gain (P &gt; 0.05), but low-RFI steers and heifers both consumed 19% less (P &lt; 0.01) DMI compared with high-RFI animals. Steers with low RFI tended (P &lt; 0.1) to have higher DM digestibility (DMD) compared with high-RFI steers (70.3 vs. 66.5 ± 1.6% DM). Heifers with low RFI had 4% higher DMD (76.3 vs. 73.3 ± 1.0% DM) and 4 to 5% higher (P &lt; 0.01) CP, NDF, and ADF digestibility compared with heifers with high RFI. Low-RFI heifers emitted 14% less (P &lt; 0.01) methane (% GE intake; GEI) calculated according to Blaxter and Clapperton (1965) as modified by Wilkerson et al. (1995), and tended (P = 0.09) to have a higher rumen acetate:propionate ratio than heifers with high RFI (GEI = 5.58 vs. 6.51 ± 0.08%; A:P ratio = 5.02 vs. 4.82 ± 0.14%). Stepwise regression analysis revealed that apparent nutrient digestibilities (DMD and NDF digestibility) for Study 1 and Study 2 accounted for an additional 8 and 6%, respectively, of the variation in intake unaccounted for by ADG and mid-test BW0.75. When DMD, NDF digestibility, and total ruminal VFA were added to the base model for Study 2, trials 2, 3, and 4, the R2 increased from 0.33 to 0.47, explaining an additional 15% of the variation in DMI unrelated to growth and body size. On the basis of the results of these studies, differences in observed phenotypic RFI in growing beef animals may be a result of inter-animal variation in apparent nutrient digestibility and ruminal VFA concentrations.
GOVERNING CHINA’S ADMINISTRATIVE MONOPOLIES UNDER THE ANTI-MONOPOLY LAW: A TEN-YEAR REVIEW (2008–2018) AND BEYOND
Authors: Zhang Zhanjiang , Wu Baiding 
Published: June 2019

ABSTRACT
An important focus of China’s Anti-Monopoly Law (AML) is “administrative monopolies”—government-imposed restraints on competition. Since adopting the AML in 2008, China gradually has strengthened its efforts to curb administrative monopolies. Despite notable reforms such as the creation of the Fair Competition Review System (FCRS), government restrictions remain a major obstacle to competition in China’s economy. The 2008 legislation narrowly defined what constitutes improper government intervention, adopted a permissive standard for determining when public restraints were legitimate, and relied heavily on internal administrative controls to correct infringements. This paper draws upon experience in China and abroad to enhance the ability of China’s competition authorities to challenge administrative monopolies. Suggested upgrades include augmenting the robustness of FCRS, introducing new tools to improve competition advocacy, bolstering the ability of competition authorities to initiate or join litigation to attack administrative monopolies, and narrowing the range of justifications that can immunize public restraints.
CHETAH: a selective, hierarchical cell type identification method for single-cell RNA sequencing
Authors: de Kanter Jurrian K , Lijnzaad Philip , Candelli Tito , Margaritis Thanasis , Holstege Frank C P 
Published: June 2019

AbstractCell type identification is essential for single-cell RNA sequencing (scRNA-seq) studies, currently transforming the life sciences. CHETAH (CHaracterization of cEll Types Aided by Hierarchical classification) is an accurate cell type identification algorithm that is rapid and selective, including the possibility of intermediate or unassigned categories. Evidence for assignment is based on a classification tree of previously available scRNA-seq reference data and includes a confidence score based on the variance in gene expression per cell type. For cell types represented in the reference data, CHETAH’s accuracy is as good as existing methods. Its specificity is superior when cells of an unknown type are encountered, such as malignant cells in tumor samples which it pinpoints as intermediate or unassigned. Although designed for tumor samples in particular, the use of unassigned and intermediate types is also valuable in other exploratory studies. This is exemplified in pancreas datasets where CHETAH highlights cell populations not well represented in the reference dataset, including cells with profiles that lie on a continuum between that of acinar and ductal cell types. Having the possibility of unassigned and intermediate cell types is pivotal for preventing misclassification and can yield important biological information for previously unexplored tissues.
Multiomics Investigation Reveals Benzalkonium Chloride Disinfectants Alter Sterol and Lipid Homeostasis in the Mouse Neonatal Brain
Authors: Herron Josi M , Hines Kelly M , Tomita Hideaki , Seguin Ryan P , Cui Julia Yue , Xu Libin 
Published: June 2019

AbstractLipids are critical for neurodevelopment; therefore, disruption of lipid homeostasis by environmental chemicals is expected to have detrimental effects on this process. Previously, we demonstrated that the benzalkonium chlorides (BACs), a class of commonly used disinfectants, alter cholesterol biosynthesis and lipid homeostasis in neuronal cell cultures in a manner dependent on their alkyl chain length. However, the ability of BACs to reach the neonatal brain and alter sterol and lipid homeostasis during neurodevelopment in vivo has not been characterized. Therefore, the goal of this study was to use targeted and untargeted mass spectrometry and transcriptomics to investigate the effect of BACs on sterol and lipid homeostasis and to predict the mechanism of toxicity of BACs on neurodevelopmental processes. After maternal dietary exposure to 120 mg BAC/kg body weight/day, we quantified BAC levels in the mouse neonatal brain, demonstrating for the first time that BACs can cross the blood-placental barrier and enter the developing brain. Transcriptomic analysis of neonatal brains using RNA sequencing revealed alterations in canonical pathways related to cholesterol biosynthesis, liver X receptor-retinoid X receptor (LXR/RXR) signaling, and glutamate receptor signaling. Mass spectrometry analysis revealed decreases in total sterol levels and downregulation of triglycerides and diglycerides, which were consistent with the upregulation of genes involved in sterol biosynthesis and uptake as well as inhibition of LXR signaling. In conclusion, these findings demonstrate that BACs target sterol and lipid homeostasis and provide new insights for the possible mechanisms of action of BACs as developmental neurotoxicants.
Effect of Virgin Coconut Oil Application on the Skin of Preterm Newborns: A Randomized Controlled Trial
Authors: Konar Mithun Chandra , Islam Kamirul , Roy Atanu , Ghosh Taraknath 
Published: June 2019

Abstract

Background
Preterm constitutes a major part of neonatal mortality, particularly in India. Due to dermal immaturity, preterm neonates are susceptible to various complications like infection, hypothermia, etc. Emollient application is a traditional practice in our subcontinent.

Aims
To find out the efficacy of coconut oil application for skin maturity, prevention of sepsis, hypothermia and apnea, its effect on long-term neurodevelopment and adverse effect of it, if any.

Material and methods
A randomized controlled trial was conducted in the rural field practice area of Department of Community Medicine, Burdwan Medical College from March 2014 to August 2018. Preterm born in the study period was divided into Group A (received virgin coconut oil application) and Group B (received body massage without any application). Neonatal skin condition was assessed on 7th, 14th, 21st and 28th day of life. Neurodevelopmental status was assessed on 3rd, 6th and 12th months.

Results
A total of 2294 preterm were included in the study. Groups A and B consisted of 1146 and 1148 preterm infants, consecutively. Mean gestational age of the study population was 31.9 ± 3.4 weeks and 50.4% were male. Mean weight loss in first few days was less in group A but mean weight gain per day was higher in group B. Lesser incidences of hypothermia and apnea, and better skin maturity and neurodevelopmental outcome were noted in group A. No significant adverse effect was noted with coconut oil application.

Conclusion
Use of coconut oil helps in dermal maturity and better neurodevelopmental outcome. Further studies are warranted for universal recommendation.
Sensory nutrition: The role of taste in the reviews of commercial food products
Authors: Reed Danielle. R. , Mainland Joel D. , Arayata Charles J. 
Published: June 2019

AbstractMany factors play a role in choosing what to eat or drink. Here we explored the role of sensation to explain these differences, drawing on consumer reviews for commercially available food products sold through an online retailer. We analyzed 393,568 unique food product reviews from Amazon customers with a total of 256,043 reviewers rating 67,553 products. Taste-associated words were mentioned more than words associated with cost, food texture, customer service, nutrition, smell, or those referring to the trigeminal senses, e.g., spicy. We computed the overall number of reviews that mentioned taste qualities: the wordtastewas mentioned in over 30% of the reviews (N= 142,768), followed bysweet(10.7%, N=42,315),bitter(2.9%, N=11,424),sour(2.1%, N=8,252), andsalty(1.4%, N=5,688). We identified 38 phrases used to describe the evaluation of sweetness, finding that ‘too sweet’ was used in nearly 0.8% of the reviews and oversweetness was mentioned over 25 times more often than under-sweetness. We then focused on ‘polarizing’ products, those that elicited a wide difference of opinion (as measured by the ranges of the product ratings). Using the products that had more than 50 reviews, we identified the top 10 most polarizing foods (i.e., those with the largest standard deviation in ratings) and provide representative comments about the polarized taste experience of consumers. Overall, these results support the primacy of taste in real-world food ratings and individualized taste experience, such as whether a product is ‘too sweet’. Analysis of consumer review data sets can provide information about purchasing decisions and customer sensory responses to particular commercially available products and represents a promising methodology for the emerging field of sensory nutrition.
Determinants of Severe Acute Malnutrition among Children age 6-59 Months Old in Two Public Hospitals, North West Ethiopia: a Case Control Study
Authors: Nebro Adonia Damtew , Asres Degnet Teferi , Prasad Reddy PCJ 
Published: June 2019

AbstractIntroductionGlobally sever acute malnutrition affects 16.4 million under five children and more than one quarter of those children live in Africa. In Ethiopia, about 3% of children are severely wasted and continues to be persistent over the past 15 years. To implement an effective intervention, it is essential to identify predictors predispose to it. This study therefore, aimed to identify determinants of severe acute malnutrition among under five children in selected public health facilities, Northwest Ethiopia.MethodsInstitution based; age matched case control study was conducted on 104 cases and 208 controls. Bivariate and multivariate analyses were done using conditional logistic regression to identify predictors. Variables having P-value ≤ 0.2 during binary analysis were entered into multivariate analysis. P value < 0.05 was considered as statistically significant.ResultsChildren from households of large family size(AOR=2.7, 95% CI: 1.06 – 6.9), having monthly income less than 1500 birr (AOR = 5.17, 95% CI: 1.7-15.3), which are food insecure (AOR = 2.9, 95% CI:1.17-7.28)), which didn’t receive any nutrition information (AOR= 3.47,95% CI: 1.14 - 7.10), didn’t practice exclusive breastfeeding (AOR = 2.69, 95% CI: 1.18 - 6.10), and practice infrequent hand washing (AOR= 7.6 95% CI:2.44-23.6) as well as children who had history of diarrhea two weeks prior to the survey (AOR 3.2, 95%CI:1.4-7.2) were more likely to suffer from severe acute malnutrition.ConclusionFamily size, monthly income, food security status, exclusive breastfeeding practice, access to information on child feeding, hand washing practice and history of diarrhea were identified to be predictors of severe acute malnutrition. Due emphasis should be given to promoting family planning, improve household livelihoods and food security, strength awareness creation on exclusive breastfeeding and frequent hand washing practices as well as prevention of diarrhea.