bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal design of parallel sliders with square-shaped textures considering fluid-structure interaction
Authors: Li Qiang , Wang Yujun , Zhang Shuo , Xu Wei-Wei , Wang Zengli , Wang Zhenbo 
Published: May 2019

Purpose
Surface texturing has been proven as an effective means of contact performance enhancement. However, limited work has been done to investigate the regular relationship to solve the multi-parameters problem of textures, and inertia effect and elastic deformation were seldom considered together in previous optimization work. This paper aims to quantitatively obtain the relationship between the textured depth and liquid film thickness and find the effect of deformation on the optimal textured height ratio in elastic parallel sliders.

Design/methodology/approach
Numerical models of hydrodynamic lubrication are established based on the computational fluid dynamic method. Elastic deformation is considered through fluid–structure interaction (FSI) method. Using response surface optimization method, textured parallel sliders are optimized with maximum loading capacity as the objective.

Findings
The results show that the optimal height ratios are all within the range of 0.60-0.65 when textured parallel sliders are considered as rigid. After considering the effect of elastic deformation, loading capacity drops and is reduced more obviously with a decrease in the elastic moduli. The optimal height ratios are within the range of 0.60-0.63, which shows that FSI has a considerable influence on loading capacity but has no significant influence on the optimal height ratio.

Originality/value
The present research provides a theoretical reference for engineering application of elastic textured parallel sliders.
A tool centre point calibration method of a dual-robot NDT system for semi-enclosed workpiece testing
Authors: Guo Canzhi , Xu Chunguang , Xiao Dingguo , Zhang Hanming , Hao Juan 
Published: May 2019

Purpose
With the development of materials science and technology, composite workpieces are increasingly used. This paper aims to discuss a non-destructive testing (NDT) solution for semi-enclosed composite workpieces. A dual-robot system with one robot that grips an irregular-shaped ultrasonic probe (tool) is established.

Design/methodology/approach
According to robotics, this paper defines the orientations of the discrete points coordinate frames in trajectory and proposes an orientation constraint rule between the tool coordinate frame and the scanning trajectory. A four-posture calibration method for calibrating the transformation relationship of the irregular-shaped tool frame relative to the robot flange frame is presented in detail.

Findings
Calibration and verification experiments were performed, and good-quality C-scan images were obtained by applying the constraint rule and the calibration method. Experimental results show that the calibration method used to determine the tool centre point (TCP) position is correct, effective and efficient; the TCP orientation constraint rule can ensure the extension pole of the irregular-shaped ultrasonic probe is parallel to the axis of the semi-enclosed cylindrical workpieces; and the ultrasonic transducer axis is perpendicular to the surface of the workpiece.

Originality/value
This paper proposes a constraint method for the posture of an irregular-shaped tool in this scheme. Theoretical foundations for the four-posture calibration method of the irregular-shaped tool for dual-robot-assisted ultrasonic NDT are presented in detail. This strategy has been successfully applied in the NDT experiment of semi-enclosed composite workpieces.
Characterization of psoriasiform dermatitis induced by systemic injection of interleukin‐23 minicircles in mice
Authors: Leys Laura , Wang Yibing , Paulsboe Stephanie , Edelmayer Rebecca , Salte Katie , Wetter Joseph , Namovic Marian , Phillips Lucy , Dunstan Robert , Gauvin Donna , Donnelly‐Roberts Diana , Su Zhi , Honore Prisca , McGaraughty Steve 
Published: May 2019

AbstractThe interleukin (IL)‐23/IL‐17 axis plays a central role in the pathogenesis of psoriasis and is elevated in lesional psoriatic skin. Different murine models have been developed to mimic this pathophysiology each carrying specific merits and limitations. In an attempt to address some of these limitations, B10.RIII mice received a single hydrodynamic injection of IL‐23 minicircles (MC) to induce hepatic transcription and the endogenous production of IL‐23. Plasma and ear IL‐23 levels were dose‐dependently (0.3–3 μg) increased in MC injected mice and were sustained over the 14‐day study duration. Beginning on day 7 post‐injection, mice developed dose‐related ear inflammation, histologically confirmed increases in epidermal and dermal area, as well as enhanced neutrophil and macrophage content. Flow cytometry demonstrated increased levels of granulocytes, T cells and monocytes/macrophages in the ear skin, with T cells identified as the main cellular source of IL‐17A. Evaluation of mRNA and protein showed time‐dependent, increased levels of the IL‐23/IL‐17 pathway and inflammatory/microbial cytokines/chemokines in the ear which differed kinetically from circulating levels. An anti‐IL‐23p40 antibody was assessed following both prophylactic administration and administration once the disease was established. Prophylactic dosing completely prevented the development of the ear phenotype across endpoints. Treatment administration showed a dose‐related response, with a maximum inhibition of 64–94%, depending on endpoint. These data demonstrate that the IL‐23 MC model is a useful approach to study IL‐23/IL‐17‐driven skin inflammation and may facilitate preclinical assessment of novel therapies.
OBG‐like ATPase 1 inhibition attenuates angiotensin II‐induced hypertrophic response in human ventricular myocytes via GSK‐3beta/beta‐catenin signalling
Authors: Narasimhan Gayathri , Henderson John , Luong Hien T , Rajasekaran Namakkal Soorapan , Qin Gangjian , Zhang Jianyi , Krishnamurthy Prasanna 
Published: May 2019

AbstractObg‐like ATPase 1 (OLA1) that possesses both GTP and ATP hydrolyzing activities has been shown to be involved in translational regulation of cancer cell growth and survival. Also, GSK3β signalling has been implicated in cardiac development and disease. However, the role of OLA1 in pathological cardiac hypertrophy is unknown. We sought to understand the mechanism by which OLA1 regulates GSK3β‐β‐Catenin signalling and its functional significance in angiotensin‐II (ANG II)‐induced cardiac hypertrophic response. OLA1 function and its endogenous interaction with GSK3β/β‐catenin signalling in cultured human ventricular cardiomyocytes (AC16 cells) and mouse hearts (in vivo) was evaluated with/without ANG II‐stimulated hypertrophic response. ANG II administration in mice increases myocardial OLA1 protein expression with a corresponding increase in GSK3β phosphorylation and decrease in β‐Catenin phosphorylation. Cultured cardiomyocytes treated with ANG II show endogenous interaction between OLA1 and GSK3β, nuclear accumulation of β‐Catenin and significant increase in cell size and expression of hypertrophic marker genes such as atrial natriuretic factor (ANF; NPPA) and β‐myosin heavy chain (MYH7). Intriguingly, OLA1 inhibition attenuates the above hypertrophic response in cardiomyocytes. Taken together, our data suggest that OLA1 plays a detrimental role in hypertrophic response via GSK3β/β‐catenin signalling. Translation strategies to target OLA1 might potentially limit the underlying molecular derangements leading to left ventricular dysfunction in patients with maladaptive cardiac hypertrophy.
Halifax Henna: The Art of Manageable Growth*
Authors: Lightstone Karen , Rixon Daphne 
Published: May 2019

ABSTRACTThis case explores the dilemma many young women face when they begin a family: juggling a full‐time job as a young Chartered Professional Accountant (CPA) with a government job, continuing to grow a small business as a henna artist, and caring for a new baby. Even before the arrival of the first child, the combination of continuing to do both jobs was not sustainable. The case provides information to enable students to assess the financial health of a small business and provides a recommendation to the owner. In addition, information regarding paying childcare costs while continuing with a government job provides a realistic comparison for students. Often students jump to the money, which is currently in her accounting job, and forget that passion, dreams, and objectives for work–life balance, although earning less at the moment due to the part‐time nature, may be the best way forward.
Sexual Orientation and Adolescent Time Use: How Sexual Minority Youth Spend Their Time
Authors: Perales Francisco , Campbell Alice , O'Flaherty Martin 
Published: May 2019

This study combines minority stress and ecological perspectives to theorize the associations between adolescents’ sexual orientation and time use. Hypotheses are tested using data from a national sample of Australian adolescents aged 14–15 years (Longitudinal Study of Australian Children; n = 3,060). Compared to heterosexual adolescents, sexual minority adolescents spent less time with their siblings and fathers, more time alone, less time in active leisure‐ and school‐based activities, and more time in nonactive leisure. There were no differences between sexual minority and heterosexual adolescents in time spent with mothers, peers, and in screen‐based leisure. Some associations were gendered. Collectively, the results suggest that sexual minority adolescents may withdraw or be excluded from critical developmental activities and the company of key social partners.
Children's experiences and needs in relation to domestic and family violence: Findings from a meta‐synthesis
Authors: Noble‐Carr Debbie , Moore Tim , McArthur Morag 
Published: May 2019

AbstractDomestic and family violence is a significant issue experienced by many children that can have severe detrimental impacts to their health, development, and well‐being. Despite the significance of this issue, it is only recently that children have been included in research that seeks to understand the impacts that domestic and family violence may have on their lives. This paper reports on the findings of a meta‐synthesis, which explored qualitative research about children's experiences of domestic and family violence. Thirty‐two studies, including from the United Kingdom, North America, and Australia were included for review. The meta‐synthesis found that children describe domestic violence as being a complex, isolating, and enduring experience that often results in disruption, losses, and challenges to their significant relationships. Children's common feelings of fear, worry, powerlessness, and sadness were also uncovered, in addition to the strategies they employed to try and facilitate the safety and emotional well‐being of themselves and their family. Children's wants and needs are also highlighted. The findings demonstrate that despite the increasing interest in children's experiences of domestic and family violence, qualitative research remains limited, with many gaps evident. Implications for research, policy, and practice are considered.
The association of overjet size and traumatic dental injuries—A systematic review and meta‐analysis
Authors: Arraj George P. , Rossi‐Fedele Giampiero , Doğramacı Esma J. 
Published: May 2019

AbstractBackground/AimsTraumatic dental injuries are one of the most prevalent diseases globally, impacting people of different ages and socio‐economic statuses. As disease prevention is preferable to management, understanding when an individual's overjet is prone to dental trauma helps identify at‐risk patients, so to institute preventive strategies. The aim of this study was to identify the different overjet sizes that present an increased risk for developing dental trauma across different ages and dentition stages.MethodsThe title and protocol were registered and published a priori with the Joanna Briggs Institute (JBI) and PROSPERO (CRD42017060907) and followed the JBI methodology of systematic reviews of association (etiology). A three‐step search strategy was performed, including electronic searches of gray literature and four databases. Studies of healthy human participants of any age and in any dental dentition stage were considered for inclusion. Only high methodological quality studies with low risk of bias were included. Where possible, meta‐analyses were performed using the random‐effects model, supplemented with the fixed‐effects model in situations where statistical heterogeneity was ≤50%, assessed using the I2 statistic.ResultsThe study identified 3718 articles, 41 were included. An increased overjet was significantly associated with higher odds of developing trauma in all dentition stages and age groups. Children 0‐6 years with an overjet ≥3mm have an odds of 3.37 (95%CI, 1.36‐8.38, P = 0.009) for trauma. Children in the mixed and secondary dentition with an overjet >5mm have an odds of 2.43 (95%CI, 1.34‐4.42, P = 0.004). Twelve‐year‐old children with an overjet >5mm have an odds of 1.81 (95%CI, 1.44‐2.27, P < 0.0001).ConclusionsThe results confirm the association between increased overjet and dental trauma. A child in the primary dentition could be considered as having an overjet at risk for trauma when it is ≥3mm. In the early secondary dentition, the threshold for trauma is an overjet ≥5mm.
Deep intronic variant c.5999‐277G>A of F8 gene may be a hot spot mutation for mild hemophilia A patients without mutation in exonic DNA
Authors: Chang Chia‐Yau , Perng Cherng‐Lih , Cheng Shin‐Nan , Hu Shu‐Hsia , Wu Tzu‐Ying , Lin Shyr‐Yi , Chen Yeu‐Chin 
Published: May 2019

AbstractBackgroundIn 10%‐18% of mild‐type hemophilia A (HA) patients, mutations cannot be found by routine DNA analysis.ObjectiveWe aimed to identify the genetic defects by mRNA analysis of F8 gene in mild HA patients without mutation in exonic DNA.Patients and methodsFrom 2006 to 2016, we identified F8 exon mutations in 39 of 49 mild HA patients using routine genetic testing. We then evaluated the 10 remaining patients from six unrelated families without exonic DNA mutation by performing cDNA sequence analysis.ResultsNine of the 10 (90%) patients were confirmed to have F8 gene mutation. Eight patients from four unrelated families were notably found to have presence of an aberrant 675‐bp fragment. Sequencing of this fragment showed that there were two separate new alternative splicing exons of 35 bp and 55 bp within intron 18, which formed a 90‐bp insertion between exon 18 and exon 19 (E18ins90bpE19) in the mRNA. Based on direct sequencing, this alternative splicing transcript appears to have resulted from deep intronic variant c.5999‐277G>A of intron 18.ConclusionsOur study suggests that deep intronic variant of c.5999‐277G>A may be a hot spot mutation for mild hemophilia patients without mutation in exonic DNA.
Discrete Choice Modeling in Education: An Innovative Method to Assess Teaching Practices
Authors: Grammatikopoulos Vasilis , Gregoriadis Athanasios , Linardakis Michalis 
Published: May 2019

AbstractSelf‐reported measures are an easy, time‐efficient, and low‐cost way to collect research data compared to other assessment methods. They are, however, characterized by several limitations regarding the quality and the clarity of the data they produce, especially when they are implemented in education. The main purpose of the current study was to use a method called discrete choice modeling (DCM) in education, in order to develop a self‐reported instrument that will reduce the bias for socially desirable responses and to assess teachers’ practices in physical activity. DCM method has the ability to overcome the respondents’ tendency to answer in a socially desirable way. A nationally representative sample of 531 Greek early educators participated in this study and were administered a self‐assessment questionnaire based on DCM. Results showed that the DCM based newly developed instrument manages to assess effectively educators’ practices and provided evidence of the applicability of the method in education. Further implications and future recommendations regarding the effective application of DCM in education are discussed.
Validity of the Kihon Checklist for evaluating frailty status in Turkish older adults
Authors: Esenkaya Mehmet Erdinc , Dokuzlar Ozge , Soysal Pinar , Smith Lee , Jackson Sarah E , Isik Ahmet Turan 
Published: May 2019

AimThe Kihon Checklist (KCL) was developed to identify vulnerable older adults residing in Japan who are at a high risk of becoming dependent. The present study aimed to determine the validity of the KCL for detecting frailty in Turkish older adults.MethodsA total of 300 outpatients were enrolled in the study. All patients underwent comprehensive geriatric assessment and completed a Turkish translation of the KCL. Frailty status was defined by five dimensions, including weight loss, exhaustion, low levels of activity, weakness and slowness: 0 for robust, 1–2 for prefrail and 3–5 for frail.ResultsThe mean age of the patients was 73.85 ± 7.12 years. According to Fried definitions, 25.7% were considered frail, 48.0% prefrail and 26.3% robust. There was a significant difference between the groups in terms of age, sex, education, Charlson's Comorbidity Index, the number of medications used, sarcopenia, dynapenia and all the comprehensive geriatric assessment parameters (P < 0.05). Cronbach's α value of the KCL was 0.876. The area under the receiver operating characteristics curve was 0.855 for frail, and 0.697 for prefrail. We found that the KCL can show frail and prefrail older adults when the cut‐off values are ≥9 and ≥ 4, respectively, with a sensitivity of 80.52% and 65.28%, and specificity of 81.17% and 56.96%.ConclusionsThe KCL can be used as a quick, simple and sensitive screening method for detecting frailty among Turkish older adults. We recommend its use by healthcare professionals in Turkey in order to identify frail older adults and direct them to relevant support. Geriatr Gerontol Int 2019; 19: 616–621.
Extraction of polyphenols and antioxidants from pomegranate peel using ultrasound: influence of temperature, frequency and operation mode
Authors: Machado Ana Paula Da Fonseca , Sumere Beatriz Rocchetti , Mekaru Carolina , Martinez Julian , Bezerra Rosângela Maria Neves , Rostagno Mauricio Ariel 
Published: May 2019

SummaryThe objective of this research was to investigate the effects of temperature (40–70 °C), frequency (37 and 80 kHz) and ultrasonic operation mode (normal, pulse and sweep), and their interactions on the recovery of phenolic compounds and antioxidants present in pomegranate peel using ultrasound‐assisted extraction. The content of individual phenolic compounds, total phenolic compounds (TPC), antioxidant capacity (AC) and total extract yield (X0) were analysed. Significant effects were observed between some sources of variation in recovery of individual compounds at TPC and X0, and no significant effect was observed for AC. The process and conditions studied shown to be interesting to extract antioxidants, since a high antioxidant capacity was verified in the extracts. Temperatures around 50–60 °C, using 37 kHz frequency, and normal or pulse modes were the conditions that provided better yields of phenolic compounds and X0. Regarding AC, the best condition observed was at 70 °C, 80 kHz frequency and continuous mode.
A Survey of Public Perceptions and Attitudes about Water Availability Following Exceptional Drought in Texas
Authors: Gholson Drew M. , Boellstorff Diane E. , Cummings Scott R. , Wagner Kevin L. , Dozier Monty C. 
Published: May 2019

AbstractThis study examines the results of a random sample survey of Texans evaluating citizen awareness, attitudes, and willingness to adopt water conservation practices. The study investigates changes in public attitudes following the most intense one‐year drought on record in Texas by evaluating public perception of water availability, assessing Texans’ attitudes and perceptions regarding drought conditions, and comparing the number of Texans adopting practices to conserve water before and after the drought of 2011. Almost 70% indicated that the likelihood of their area suffering from a prolonged drought was increasing. More than 61% of respondents have changed the way their yard is landscaped and 62% have also adopted new technologies in an effort to conserve water. Overall, responses indicated that Texans are concerned with water availability after experiencing, in 2011, the worst one‐year drought on record, and that the majority of respondents are taking personal action in an effort to conserve water for the future.
The role of the dermatologist in the immune‐mediated/allergic diseases – position statement of the EADV task force on contact dermatitis, EADV task force on occupational skin diseases, UEMS‐EBDV subcommission allergology and European Dermatology Forum
Authors: Balato A. , Raimondo A. , Arenberger P. , Bruze M. , Czarnecka‐Operacz M. , Johanssen J.D. , Gonçalo M. , Ranki A. , Uter W. , Wilkinson M. , Ayala F. , John S.M. , Giménez‐Arnau A. , Gollnick H. 
Published: May 2019

AbstractBackgroundThe members of the Task Force on Contact Dermatitis and the Task Force on Occupational Dermatoses of the European Academy of Dermatology and Venereology (EADV), of the European Dermatology Forum (EDF), and the members of the UEMS Section of Dermatology‐Venereology (UEMS‐EBDV) we want to vindicate the fundamental role that the specialist in Dermatology has in the diagnosis and management of Immuno‐mediated /allergic Diseases.ObjectiveIn disagreement with the blueprint paper of the UEMS section of Allergology (2013), in which dermatologists are excluded from one of their core activities it was decided to write this consensus paper.DiscussionThe skin occupies a crucial place in the broad spectrum of allergic diseases; there is no other organ with such a multitude of different clinical conditions mediated by so many pathogenetic immune mechanisms. Subsequently, dermatologists play a fundamental role in the management of immune‐mediated diseases including among others contact dermatitis, atopic dermatitis, urticaria and angioedema or cutaneous adverse drug, food and arthropod reactions. The essential role of dermatology in the diagnostic, therapeutic and preventive management of immune mediated /allergic diseases which is crucial for patient management is justified from both the academic and professional point of view.ConclusionBased on the best care of the patient with cutaneous immune allergic disease a multidisciplinary approach is desirable and the dermatologist has a pivotal role in patient management. Be so good and no one will not ignore you, dermatologist. Ideally Dermatology should be governed according the following Henry Ford statement: “Arriving together is the beginning; keeping together is progress; working together is success.”
What is the extracellular calcium concentration within brain synapses?
Authors: Lopes João Pedro , Cunha Rodrigo A. 
Published: May 2019

AbstractCalcium (Ca2+) is essential for the normal functioning of the brain: Ca2+ inflow into synaptic compartments is a major trigger of neurotransmitter release and of long‐term plastic changes of synaptic efficiency. Ca2+ influx depends on the gradient for this ion across the plasma membrane, and slight fluctuations of extracellular Ca2+ concentration have significant impact on axonal excitability, synaptic transmission, and plasticity. The work by Forsberg et al. reports a concentration of physiologically active Ca2+ in human cerebrospinal fluid (CSF) that is half of that normally used in artificial CSF in electrophysiological brain slice experiments. By studying the impact of such difference of extracellular Ca2+ concentration, the authors reported significant differences in terms of neuronal excitability and long‐term potentiation in rat hippocampal slices. We now discuss these new findings in the context of the spatial organization of synapses, on the role of astrocytes in filtering the synaptic content and on the complexity of plasticity in a broad context of metaplastic modifications of synaptic efficiency.
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