bluuebunny/crossref_metadata_2025_split huggingface dataset:
Einfluss der Glukokortikoidtherapie auf die intratherapeutische Bio distribution von 131I bei der Radio jodtherapie des Morbus Basedow
Authors: Halstenberg Jörg , Kranert Wolfgang , Korkusuz Hüdayi , Mayer Amelie , Ackermann Hanns , Grünwald Frank , Happel Christian 
Published: October 2018

Zusammenfassung
Ziel: Die Radiojodtherapie (RJT) ist ein wichtiges Therapieverfahren in der definitiven Behandlung des Morbus Basedow (MB). Allerdings kann die RJT die Entstehung einer endokrinen Orbitopathie triggern oder eine bereits bestehende endokrine Orbitopathie verstärken. Die Leitlinie der Deutschen Gesellschaft für Nuklearmedizin (DGN) empfiehlt daher bei vorbestehender endokriner Orbitopathie eine therapiebegleitende Glukokortikoidgabe. Ziel dieser Studie ist es, den Einfluss einer protektiven Glukokortikoidtherapie auf die intratherapeutische Biokinetik des 131I bei Patienten mit MB zu untersuchen. Material und Methoden: In einer retrospektiven Analyse wurden 211 Patienten mit MB untersucht, die sich ohne thyreostatische Medikation einer RJT unterzogen hatten. Es wurden prä- und intratherapeutisch der extrapolierte maximale Uptake (EMU) und die effektive Halbwertszeit des 131I in der Schilddrüse ermittelt. Patienten mit endokriner Orbitopathie erhielten ab dem Vortag der RJT Glukokortikoide nach einem festgelegten Schema, Patienten ohne endokrine Orbitopathie erhielten keine Glukokortikoide. Zur Auswertung wurden die intratherapeutisch ermittelten Parameter auf die prätherapeutisch im Radiojodtest ermittelten Parameter bezogen und die beiden Gruppen hinsichtlich dieser Quotienten statistisch miteinander verglichen. Um weitere Faktoren zu berücksichtigen, wurden die Gruppen auch in Hinblick auf Alter, Gewicht sowie TSH, TRAK, TAK und MAK untersucht. Ergebnisse: In der Gruppe der Patienten mit Glukokortikoideinnahme zeigte sich ein Rückgang des medianen EMU von 44 % im Radiojodtest auf intratherapeutisch 35 %. In der Kontrollgruppe ohne Glukokortikoide entsprach der prätherapeutische (47 %) dem intratherapeutischen EMU (46 %). Im Vergleich der EMU-Änderung der beiden Gruppen zeigte sich ein statistisch signifikanter Unterschied (p < 0,001). Der Vergleich aller weiteren Parameter einschließlich der effektiven Halbwertszeit (p = 0,79) ergab keine signifikanten Unterschiede zwischen beiden Gruppen. Schlussfolgerung: Die Ergebnisse der vorliegenden Studie legen nahe, dass Glukokortikoide einen Einfluss auf die Biokinetik von 131I haben, indem sie dessen Speicherung in der Schilddrüse reduzieren. Für Patienten unter Glukokortikoidtherapie, die keine thyreostatische Medikation erhalten, könnte daher eine entsprechende Anpassung der aus den Daten des Radiojodtests berechneten 131I-Therapieaktivität erwogen werden.
Image Quality Assessment for Low-Dose-CT in Hybrid SPECT/CT Imaging
Authors: Ruf Juri , Kupitz Dennis , Czuczwara Damian , Loewenthal David , Thormann Markus , Furth Christian , Ricke Jens , Pech Maciej , Kreissl Michael , Amthauer Holger , Grosser Oliver 
Published: October 2018

Summary
Objectives: Low-dose-computed tomography (LD-CT) is used in nuclear medicine hybrid imaging (e.g., SPECT/CT) for attenuation correction of emission data and anatomical correlation of findings. However, there are currently no standards for image quality (e. g., detectability) comparable to those for diagnostic CT. Therefore, the aim of this explorative study was to evaluate retrospective LDCT data in terms of CT image quality and detectability of anatomical structures. Methods: Two readers blindly scored abdominal LD-CT images (n = 40 patients) in terms of detectability (n = 20 structures/patient), image quality, and readers’ confidence in scoring the image quality for a clinically hybrid imaging protocol. Results were analysed by ANOVA to identify factors (e. g., anatomical structures) that influenced performance scores. The inter-rater agreement was evaluated by determining the chance-corrected Cohen’s Kappa coefficient. Results: Image noise was acceptable for anatomical correlation in 96.1 % of the readings with an almost perfect inter-rater agreement (KBP = 0.85). A detectability of at least 80 % was observed in 13/20 (KBP ≥ 0.7) and 90 % in 9/20 (KBP ≥ 0.85) of the structures analysed by both readers. The confidence of both readers in scoring image quality was at least sufficient in 98.8 % of the examined patients (KBP = 0.95). Conclusion: Although LD-CT protocols commonly used in hybrid imaging have a poor image quality not suitable for primary CT diagnostics, they enable detection of a variety of anatomical structures. LDCT can therefore also be referenced in the associated reports for anatomical correlation of findings from SPECT imaging.
Immunohistochemical detection of chemokine receptor 4 expression in chronic osteomyelitis confirms specific uptake in 68Ga-Pentixafor-PET/CT
Authors: Bouter Yvonne , Meller Birgit , Sahlmann Carsten , Wolf Bettina , Langer Laura , Bankstahl Jens , Wester Hans , Kropf Saskia , Meller Johannes , Bouter Caroline 
Published: October 2018

SummaryPrevious findings of our group showed the chemokine receptor CXCR4 as a suitable target in PET/CT-imaging of axial bone infections, early postoperative osteomyelitis and periprosthetic infections. The aim of this study was to verify specific uptake of 68Ga-Pentixafor in chronic osteomyelitis. Methods: 29 consecutive patients who underwent 68Ga-Pentixafor-PET/CT with clinically suspected osteomyelitis were evaluated retrospectively. Bone tissues of 6 patients were available and evaluated by immunohistochemical staining for CXCR4 and autoradiography with 68Ga-Pentixafor. Staining was performed with an anti-CXCR4 antibody. In order to detect lymphocytic infiltration and CXCR4-expressing lymphocytes double immunofluorescence with an anti-CD3 and anti-CXCR4 antibody was performed. Results: 68Ga-Pentixafor-PET/ CT was true positive in 16 and true negative in 13 patients. In available bone tissue samples, immunohistochemical staining of CXCR4 expression and autoradiography with 68Ga-Pentixafor was highly positive. Double immunofluorescence was able to detect CXCR4-expressing T-lymphocytes within all bone samples while a control sample of noninfected tibial bone was negative for CXCR4. Conclusion: 68Ga-Pentixafor-PET/CT specifically shows CXCR4-expressing immune cells in chronic osteomyelitis and is therefore a suitable method for imaging chronic infection of the skeleton.
Treatment of Osteochondrosis Dissecans of the Canine Stifle Using Synthetic Osteochondral Resurfacing
Authors: Murphy Susan , Jovanovik Jelena , Tucker Russell , Fitzpatrick Noel , Egan Pádraig 
Published: October 2018

Objective This article aimed to describe the use and evolution of a synthetic osteochondral resurfacing (SOR) implant in the treatment of osteochondrosis dissecans (OCD) of the femoral condyle and to report the clinical, radiographic, computed tomography and magnetic resonance imaging outcomes of this technique.
Methods Medical records of dogs that were treated with first-generation (G1) and second-generation (G2) SOR at a single institute were reviewed. Surgical reports and clinical examinations as well as the preoperative, postoperative, and follow-up radiographs, computed tomographic images and magnetic resonance imaging images were reviewed.
Results Fourteen stifles (nine dogs) were included in the study. G1-SOR implants were employed in six stifles of four dogs and G2-SOR implants in eight stifles of five dogs. Osteochondrosis dissecans of the medial femoral condyle was confirmed as the sole pathology in all dogs treated with G1-SOR. Only one of eight OCD lesions was located on the medial condyle in the G2-SOR group with the remaining seven lesions affecting the lateral femoral condyle. At 12 weeks, 13 of 14 stifles displayed implant stability, with no subchondral bone changes or evidence of lucency around any implant. Eight of nine dogs achieved a good-excellent clinical outcome. Complications included one minor surgical site infection and one infective arthritis which required implant removal.
Clinical Significance In this cohort of dogs, both G1-SOR and G2-SOR were successful and repeatable surgical procedures for dogs with OCD of the femoral condyle.
Reduction of the A-Frame Angle of Incline does not Change the Maximum Carpal Joint Extension Angle in Agility Dogs Entering the A-Frame
Authors: Glyde Mark , Hosgood Giselle , Dempsey Alasdair , Wickham Sarah , Appelgrein Carla 
Published: October 2018

Objective This article aims to investigate the effect of a decrease in the A-frame angle of incline on the highest carpal extension angle in agility dogs.
Methods Kinematic gait analysis (two-dimensional) measuring carpal extension was performed on 40 dogs entering the A-frame at 3 angles of incline: 40° (standard), 35° and 30°. The highest carpal extension angle from three trials at each incline was examined for a significant effect of A-frame angle with height, body weight and velocity included as covariates.
Results There was no significant effect of A-frame angle on the highest carpal joint extension angle for the first or second limb. The adjusted mean carpal extension angle for the first limb at 40° was 64° [95% confidence interval (CI), 60–68), at 35° was 61° (95% CI, 57–65) and at 30° was 62° (95% CI, 59–65). The raw mean carpal extension angle for all dogs across all A-frame angles for the first limb was 62° (95% CI, 60–64) and the second limb was 61° (95% CI, 59–63).
Clinical Significance Decreasing the A-frame angle of incline from 40° to 30° did not result in reduced carpal extension angles. The failure to find a difference and the narrow CI of the carpal angles may indicate that the physiologic limits of carpal extension were reached at all A-frame angles.
Dust Emission in an Accretion-rate-limited Sample of z ≳ 6 Quasars
Authors: Venemans Bram P. , Decarli Roberto , Walter Fabian , Bañados Eduardo , Bertoldi Frank , Fan Xiaohui , Farina Emanuele Paolo , Mazzucchelli Chiara , Riechers Dominik , Rix Hans-Walter , Wang Ran , Yang Yujin 
Published: October 2018

Abstract
We present Atacama Large Millimeter Array 1 mm observations of the rest-frame far-infrared (FIR) dust continuum in 27 quasars at redshifts 6.0 ≲ z < 6.7. We detect FIR emission at ≳3σ in all quasar host galaxies with flux densities at ∼1900 GHz in the rest-frame of 0.12 < S
rest,1900 GHz < 5.9 mJy, with a median (mean) flux density of 0.88 mJy (1.59 mJy). The implied FIR luminosities range from

= (0.27–13) × 1012

, with 74% of our quasar hosts having

> 1012

. The estimated dust masses are

= 107–109

. If the dust is heated only by star formation, then the star formation rates in the quasar host galaxies are between 50 and 2700

. In the framework of the host galaxy–black hole coevolution model a correlation between ongoing black hole growth and star formation in the quasar host galaxy would be expected. However, combined with results from the literature to create a luminosity-limited quasar sample, we do not find a strong correlation between quasar UV luminosity (a proxy for ongoing black hole growth) and FIR luminosity (star formation in the host galaxy). The absence of such a correlation in our data does not necessarily rule out the coevolution model, and could be due to a variety of effects (including different timescales for black hole accretion and FIR emission).
Inefficient Cosmic-Ray Diffusion around Vela X: Constraints from H.E.S.S. Observations of Very High-energy Electrons
Authors: Huang Zhi-Qiu , Fang Kun , Liu Ruo-Yu , Wang Xiang-Yu 
Published: October 2018

Abstract
Vela X is a nearby pulsar wind nebula (PWN) powered by a ∼104 year old pulsar. Modeling of the spectral energy distribution of the Vela X PWN has shown that accelerated electrons have largely escaped from the confinement, which is likely due to the disruption of the initially confined PWN by the supernova remnant reverse shock. The escaped electrons propagate to the Earth and contribute to the measured local cosmic-ray (CR) electron spectrum. We find that the escaped CR electrons from Vela X would hugely exceed the measured flux by High Energy Stereoscopic System (HESS) at ∼10 TeV if the standard diffusion coefficient for the interstellar medium (ISM) is used. We propose that the diffusion may be highly inefficient around Vela X and find that a spatially dependent diffusion can lead to CR flux that is consistent with the HESS measurement. Using a two-zone model for the diffusion around Vela X, we find that the diffusion coefficient in the inner region of a few tens of parsecs should be ≲1028 cm2 s−1 for ∼10 TeV CR electrons, which is about two orders of magnitude lower than the standard value for the ISM. Such inefficient diffusion around PWN resembles the case of the Geminga and Monogem PWNe, suggesting that inefficient diffusion may be common in the vicinity of PWNe that span a wide range of ages.
Radio Properties of Rotating Radio Transients: Single-pulse Spectral and Wait-time Analyses
Authors: Shapiro-Albert B. J. , McLaughlin M. A. , Keane E. F. 
Published: October 2018

Abstract
Rotating radio transients (RRATs) are a sub-class of pulsars characterized by sporadic emission and thus can generally only be studied by analysis of their single pulses. Here we present a single-pulse analysis using 11 years of timing data at 1400 MHz of three RRATs, PSRs J1819−1458, J1317−5759, and J1913+1330. We perform a spectral analysis on the single pulses of these RRATs for the first time, finding their mean spectral indices to be −1.1 ± 0.1, −0.6 ± 0.1, and −1.2 ± 0.2 respectively, within the known range of pulsar spectral indices. We find no evidence for narrowband features as seen for FRB 121102. However, we find the spread of single-pulse spectral indices for these RRATs (ranging from −7 to +4) to be larger than has been seen in other pulsars, with the exception of the Crab pulsar. We also analyze the time between detected pulses, or wait time, and find that the pulses are not random and cluster around wait times of a few pulse periods as well as ∼25 pulse periods for PSRs J1819−1458 and J1317−5759. Additionally we find that there is no correlation between the wait time and pulse flux density. Finally we find that the distribution of the pulse energy for PSRs J1317−5759 and J1913+1330 are log-normal, while that of PSR J1819−1458 is log-normal with possible evidence of an additional power-law component.
Increased dose of Dolutegravir as a Potential Rescue Therapy in Multi-Experienced Patients
Authors: Ferrari Davide , Spagnuolo Vincenzo , Manca Monica , Bigoloni Alba , Muccini Camilla , Banfi Giuseppe , Locatelli Massimo , Castagna Antonella 
Published: October 2018

Background The pilot Phase IIb VIKING study suggested that dolutegravir (DTG), an HIV integrase inhibitor (INI), is efficacious in INI-resistant patients at the 50 mg twice-daily dose. However, DTG response was most reduced in subjects carrying resistance-associated mutations at position G140 and Q148. These mutations can cause a 10–20-fold reduced susceptibility to DTG as well as a 96% lower odds of achieving HIV-1 RNA <50 copies/ml at week 24 if compared with those with no mutations at these positions. Methods Five multi-experienced patients harbouring the mutation complex G140-Q148, resistant to at least three drug classes, and previously exposed to DTG 50 mg twice daily, were treated with an increased dose of DTG (100 mg twice daily) in association with an optimized background regimen (OBR) based on their individual viral genotyping assays. The blood concentration of DTG was measured in order to determine whether a solubility issue is related with this high dosage. Results Four out of five patients attained an HIV-1 RNA <50 copies/ml at week 48 and no relevant adverse events were detected. The measured DTG blood concentration was that expected for the administered dosage, ruling out any solubility concerns. Conclusions For the first time 100 mg twice daily of DTG was administered to five multi-experienced patients harbouring the mutation complex G140-Q148. Although a small number of patients were tested, the results show a potential for a high-dose regimen of DTG as a rescue therapy in patients harbouring integrase strand transfer inhibitor resistant viruses.
Dernier retour sur les formalistes
Authors: Todorov Tzvetan 
Published: October 2018

Cet article revient sur les circonstances de la publication de Théorie de la littérature. Textes des formalistes russes , réunis, présentés et traduits par Tzvetan Todorov, avec une préface de Roman Jakobson, en 1966. Il rappelle ensuite les trois moments de lecture critique des formalistes par Todorov : en 1965 ; en 1982, dans Critique de la critique ; et enfin en 1997, dans une étude intitulée « Pourquoi Jakobson et Bakhtine ne se sont jamais rencontrés ».
Le « formalisme » polonais et l’héritage du formalisme russe
Authors: Mrugalski Michał , Conan Jérémie , Roussin Philippe 
Published: October 2018

L’article décrit l’héritage du Cercle de Varsovie, qui fut actif durant la seconde moitié des années 1930 et qui comptait notamment parmi ses membres Stefan Żółkiewski, Kazimerz Budzyk, Franciszek Siedlecki et Dawid Hopensztand. L’article insiste notamment sur le trait le plus caractéristique du structuralisme polonais de l’entre-deux-guerres, à savoir la notion de formalisme méthodologique , qui consiste à examiner la « syntaxe logique » d’une science qui préexiste à la transmission des réseaux de notions et de données empiriques fondées sur des théories. La manière dont ce « formalisme » fonctionne est démontrée au moyen du modèle du discours indirect libre et du discours satirique de Hopensztand, au sein duquel un réseau solide de notions a priori permet d’effectuer des sauts audacieux entre les différents domaines de l’expérience humaine. Ce modèle connaît un regain d’actualité dans le contexte des études littéraires actuelles, qui s’efforcent de faire tomber les barrières entre le littéraire et le social, tout en exprimant un intérêt croissant pour les découvertes des sciences de la vie.
Monde narratif et sémiosphère
Authors: Pier John 
Published: October 2018

La sémiosphère, notion développée par Jurij Lotman à partir de 1984, fournit les moyens de repenser le monde narratif dans le cadre de la sémiotique culturelle à partir de concepts comme la binarité, l’asymétrie, l’hétérogénéité, la frontière, la traductibilité, etc. La frontière est cruciale dans la génération de la sémiosphère, comme dans les différents types de récit, et donc dans la nature du monde narratif. Le texte sans sujet (où la frontière n’est pas enfreinte, comme dans le mythe d’origine) s’oppose au texte à sujet (où l’histoire est déclenchée par la violation d’un tabou, par exemple). L’article examine les notions de storyworld (David Herman) et d’ événementialité (Wolf Schmid) afin de mettre en perspective les enjeux du monde narratif tel qu’il est conçu selon les principes de la sémiosphère. Le storyworld correspond à la construction mentale du monde raconté dans l’esprit du lecteur ; l’événementialité désigne la gradualité de l’événement narratif et prend en compte les degrés de pertinence et d’imprévisibilité des changements d’état perçus par le personnage comme par le lecteur.
Proposition d’un design de recherche pour l’analyse des processus complexes et émergents en systèmes d’information : de l’intérêt de combiner étude(s) de cas et simulation multi-agents
Authors: Habib Johanna , de Corbière François 
Published: October 2018

Si la simulation connaît une popularité croissante en sciences des organisations, force est de constater que les recherches en systèmes d’information (SI) emploient encore peu fréquemment cette approche méthodologique. Après avoir mis en exergue la pertinence de la simulation pour explorer des phénomènes complexes et émergents, cet article se propose de souligner l’intérêt d’un design de recherche combinant deux approches méthodologiques : l’étude de cas et la simulation multi-agents. Deux modèles de simulation en SI sont présentés pour illustrer l’apport de ce couplage méthodologique, en particulier sur la question épineuse de la validité des résultats de simulation. En effet, à travers un processus experimentalo-abductif l’ancrage qualitatif de la simulation améliore la validité du modèle construit tout autant qu’il accroît la portée de l’interprétation des résultats de la simulation. En retour, l’ancrage simulatif permet de poser de nouvelles questions de nature plus théorique et prospective, et renforce par la même la généralisation théorique des résultats. Ce croisement méthodologique amène toutefois à revoir le positionnement de la simulation dans le design de recherche. La simulation n’occupe plus une place centrale dans la construction des connaissances scientifiques mais davantage une place complémentaire, un dépassement à l’étude de cas, permettant de renouveler les questionnements du chercheur.
3D Integrated High-Precision Passives on Thin Glass Substrates for Miniaturized and High-Performance RF Components
Authors: Wu Zihan , Min Junki , Pulugurtha Markondeya Raj , Ravichandran Siddharth , Sundaram Venky , Tummala Rao R. 
Published: October 2018

Abstract
Double-side or 3-D integration of high-precision and high-performance bandpass and lowpass filters that are interconnected with through-vias were designed and demonstrated on 100-micron thin glass substrates for ultra-miniaturized diplexer components. A novel process for achieving high precision with large-area fabrication was developed to achieve much improved tolerance in electrical performance. High-precision, high quality factor, and high component densities with thin-film layers on glass were used to realize innovative topologies on glass for high out-of-band rejection and low insertion loss. Low-loss 100-μm thick glass cores and multiple layers of 15-μm thin polymer films were used to build the filters on substrates. The demonstrated diplexers have dimensions of 2.3 ×2.8 ×.2 mm. Aided by the dimensional stability of glass and process control with semiadditive patterning, the performance of the fabricated filters showed excellent correlation with the simulation. The impact of process-sensitivity analysis on diplexer performance was also analyzed. Finally, a unique and innovative process solution was demonstrated to control the process deviation and achieve good diplexer tolerance. The performance deviation was controlled by ~3.5X with the new process.
A Simple Method for Thermal Characterization of Stacked Die Electronic Packages in Staggered Arrangement
Authors: Bharadwaj Bharath R. , Kandagadla SriNithish , Nadkarni Praveen J. , Krishna V. , Seetharam T. R. , Seetharamu K. N. 
Published: October 2018

Abstract
The need for compactness and efficiency of processing devices has kept increasing rapidly over the past few years. This need for compactness has driven the dice to be stacked one above the other. But with this come the difficulty of heat dissipation and its characterization because there are multiple heat sources and a single effective heat-conductive path. Hence, it becomes important to know the distribution and characterization of heat and temperature to provide effective cooling systems. In this article, we discuss the temperature distribution of various power configurations on stacked dice with five dice, when the dice are in staggered arrangement. The simulations have been carried out for both free convection and forced convection conditions using the ANSYS commercial software. The linear Superposition principle (LSP) is demonstrated on these configurations and validated with the results obtained from ANSYS simulation. LSP can be applied for the quick estimation of die temperatures with negligible error.