bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factor VIII Ise (R2159C) in a Patient with Mild Hemophilia A, an Abnormal Factor VIII with Retention of Function but Modification of C2 Epitopes
Authors: Suzuki Hiroshi , Shima Midori , Arai Morio , Kagawa Kazuhiko , Fukutake Katuyuki , Kamisue Seiki , Nakai Hiroaki , Morichika Shogo , Tanaka Ichiro , Inoue Masakazu , Gale koren , Tuddenham Edward G D , Yoshioka Akira 
Published: July 2018

SummaryWe found a patient with mild hemophilia A who had no detectable factor VIII antigen (FVIII:Ag), as shown by two-site ELISA using inhibitor
alloantibodies (TK). We then analyzed A2, A2/B, and C2 antigen of the patient's DDAVP-induced FVIII using several anti-FVIII
monoclonal antibodies. Factor VIII activity (FVIII : C) was increased from 12 to 42 Uldl by the administration of DDAVP. The DDAVPinduced increases in the A2 and A2/B antigens were 40 and 36 Uldl, respectively. However, the increase in the C2 antigen was only 7.5 Uldl. SSCP analysis and subsequent sequencing demonstrated an Arg to Cys transition at codon 2159. The anti-FVII1:C titer of monoclonal antibody, NMC-VIII15 which recognized the C2 domain, against normal plasma was 450 Bethesda Ulmg of IgG. However, the titer against DDAVP-treated patient's plasma was only 15 Bethesda Ulmg. We also tested DDAVP-induced increase in the FVIII : Ag in another mild hemophilia A patient with the same mutation at Arg2159. Increase in his C2 antigen levels was only 19% of those in the A2 and A2/B antigen. We designate this abnormal FVIII as FVIII Ise. Our results show that a missense mutation at Arg2159 to Cys modifies the antigenicity of the C2 domain.
Hypertensive Disorders during Pregnancy and Risk of Bronchopulmonary Dysplasia in Very Preterm Infants
Authors: de Lima Filipa , Machado Ana , Guimarães Hercília , Rocha Gustavo ,   Hypertensive Disorders of Pregnancy Study Group
Published: July 2018

Introduction It is not yet fully known whether hypertensive disorders (HTD) during pregnancy impose an increased risk of development of bronchopulmonary dysplasia (BPD) in preterm newborn infants.
Objective To test the hypothesis that preeclampsia and other HTD are associated with the development of BPD in preterm infants.
Materials and Methods Data on mothers and preterm infants with gestational age 24 to 30 weeks were prospectively analyzed in 11 Portuguese level III centers. Statistical analysis was performed using IBM SPSS statistics 23.
Results A total of 494 preterm infants from 410 mothers were enrolled, and 119 (28%) of the 425 babies, still alive at 36 weeks, developed BPD. The association between chronic arterial hypertension, chronic arterial hypertension with superimposed preeclampsia, and gestational hypertension in mothers and BPD in preterm infants was not significant (p = 0.115; p = 0.248; p = 0.060, respectively). The association between preeclampsia–eclampsia and BPD was significant (p = 0.007). The multivariate analysis revealed an association between preeclampsia–eclampsia and BPD (odds ratio [OR] = 4.6; 95% confidence interval [CI] 1.529–13.819; p = 0.007) and a protective effect for BPD when preeclampsia occurred superimposed on chronic arterial hypertension in mothers (OR = 0.077; 95%CI 0.009–0.632; p = 0.017).
Conclusion The results of this study support the association of preeclampsia in mothers with BPD in preterm babies and suggest that chronic hypertension may be protective for preterm babies.
The Effect of Indentation Load, Tilted Angle, and the Amount of Surface Removal to the Fracture Toughness of Silicon Nitride Measured by the Surface Crack in Flexure (SCF) Test Method
Authors: Nindhia T. G. T. 
Published: July 2018

Abstract
The surface crack in flexure (SCF) is a method for the evaluation of the fracture toughness of advanced ceramics. Conventionally is practiced by using a Knoop indenter to make a very small precrack. Removal on indent and the plastically deformed zone is required before the fracture test. The purpose of this removal is to eliminate residual stresses under the Knoop impression and to obtain a semi elliptical precrack shape. In this work the influence of the variation of several experimental parameters is investigated. Fracture toughness values by the SCF method are compared with those measured using the SEVNB (single edge V-notched beam) method. The material chosen for this purpose was gas pressured sintered silicon nitride (Si3N4) containing 3wt.%Al2O3 and 3 wt.%Y2O3 (SL200B, Ceram Tec, Plochingen, Germany). The varied parameters were indentation load, orientation of the indentation crack with respect to the bending axis and the amount of material removed from the surface. Additional investigations were performed to determine the crack geometry for various indentation loads. A procedure was developed to facilitate the location and measurement of the precrack size on the fracture surfaces. The effect of measurement accuracy of the results is evaluated. The fracture toughness of specimens with a surface removal in the range suggested from ASTM C 1421 were found to agree with the results obtained from SEVNB. A surface removal below the recommendation resulted in low values of fracture toughness. Increasing the amount of surface removal moderately was found to still fit with results obtained from SEVNB. Surface removal of much more from the recommended amount leads to failure from natural flaws. Observations from serial sectioning revealed that precracks obtained from HK20 and HK30 have an irregular precrack shape with large lateral cracks. It is suggested to use HK5 and HK10 to produce semi-elliptical surface cracks.
Low energy solution ball milling of graphene nanoplatelets (GNPs) reinforced aluminium nanocomposites and its mechanical properties
Authors: Baig Z , Mamat O , Mustapha M , Ali S , Yasir M 
Published: July 2018

Abstract
Graphene Nanoplatelets (GNPs) possess outstanding properties which can be utilized to reinforce Al metal for various applications of automotive and aerospace sectors. The major hurdle for real-time applications is the GNPs dispersion in Al matrix which is a challenging task. To address this issue, a combination of processing like solvent dispersion via tip sonication and low energy ball milling at 200 and 300rpm were employed to investigate the GNPs dispersion at various fractions and their effects on final nanocomposite properties. Microstructural analysis of nanocomposite powder was carried out to investigate dispersion analysis. A decrease in relative density with increase in GNPs content showed by all samples. Hardness and wear characterization of the nanocomposite samples were performed. It was found that 0.3wt%GNPs/Al samples has shown maximum increase in hardness (35.61%) and reduce wear rate of (76.68%) than pure Al at 300rpm milling. Finally, GNPs have shown their reinforcing effect by increasing hardness and wear rate by provide effective lubrication.
A similarity-based approach to leverage multi-cohort medical data on the diagnosis and prognosis of Alzheimer's disease
Authors: Zhang Hongjiu , Zhu Fan , Dodge Hiroko H , Higgins Gerald A , Omenn Gilbert S , Guan Yuanfang ,   the Alzheimer's Disease Neuroimaging Initiative
Published: July 2018

Abstract

Motivation
Heterogeneous diseases such as Alzheimer's disease (AD) manifest a variety of phenotypes among populations. Early diagnosis and effective treatment offer cost benefits. Many studies on biochemical and imaging markers have shown potential promise in improving diagnosis, yet establishing quantitative diagnostic criteria for ancillary tests remains challenging.

Results
We have developed a similarity-based approach that matches individuals to subjects with similar conditions. We modeled the disease with a Gaussian process, and tested the method in the Alzheimer's Disease Big Data DREAM Challenge. Ranked the highest among submitted methods, our diagnostic model predicted cognitive impairment scores in an independent dataset test with a correlation score of 0.573. It differentiated AD patients from control subjects with an area under the receiver operating curve of 0.920. Without knowing longitudinal information about subjects, the model predicted patients who are vulnerable to conversion from mild-cognitive impairment to AD through the similarity network. This diagnostic framework can be applied to other diseases with clinical heterogeneity, such as Parkinson's disease.
Institutions for People with Disabilities in North America
Authors: Noll Steven 
Published: July 2018

Abstract
The institution or asylum in North America was established as a mechanism for confining, controlling, and containing groups of individuals classified and labeled as mentally ill or intellectually disabled and defined as deviant, defective, or delinquent. These congregate facilities, established both for the protection of the individuals housed there and for the simultaneous protection of society from those same people, developed into massive structures designed to accommodate thousands of residents/patients/inmates. The rationale behind the rapid rise of the institution throughout the nineteenth and into the mid-twentieth centuries paralleled the growth of modern medicine and psychiatry. By the 1950s, institutions housed hundreds of thousands of individuals. Yet by the start of the twenty-first century, the institutional model had been intellectually discredited, and these facilities had been all but abandoned. This rather astounding demise mirrored broader social, scientific, and medical trends.
Picturing Disability in Eighteenth-Century England
Authors: Turner David M. 
Published: July 2018

Abstract
The eighteenth century is often seen as a time when disability became increasingly marginalized in visual culture. However, a glimpse beyond the classical tastes of “high” art reveals not a disappearance but a flourishing of representations of physical and sensory difference. Eighteenth-century popular art and satirical prints examined the disabled body not just as a symbol of misfortune or target for medical intervention, but also as a source of pleasure or an object of satire that conveyed wider messages about the times. A rich and varied range of pictorial representations of disability in the long eighteenth century (ca. 1680–ca. 1830) contributed to social, cultural, and medical understandings of bodily difference in English culture. People with disabilities played important roles as artists, models, and critics in an era before modern “disability arts.”
Disabled Veterans and the Wounds of War
Authors: Gerber David A. 
Published: July 2018

Abstract
War is an abiding cause of death, disability, and disease. Disabled and chronically ill veterans of military conflict, as well as civilian victims of wars, have been neglected, both in popular memories and in academic research. But as long as people find disabled veterans convenient symbols of patriotism and sacrifice, they will continue to be a special project of the state, with a unique status separate from nondisabled and disabled civilians. Though there is still no synthesis of the history of disabled veterans, the outlines of one have been taking shape, emphasizing (1) the evolving nature of injuries to bodies and minds in the contexts of warfare, weaponry, and military medicine; (2) military citizenship; (3) identity; and (4) cultural representations.
Love and Time
Authors: Ben-Ze’ev Aaron , Krebs Angelika 
Published: July 2018

Abstract
The connection between romantic love and time has always fascinated lovers, who ask themselves if their love will endure always and forever. And if it does, will it be the same as it is now? This chapter argues that romantic love can indeed endure for a long time without necessarily declining into something like friendship or companionate love. In order to show this, it provides various conceptual tools that can help to understand enduring emotions in general and enduring romantic love in particular, such as the distinctions between acute, extended, and enduring emotions, or between superficial and profound emotions. Finally, it tests this position by applying it to the issues of old age, sickness, and death, as exemplified in Michael Haneke’s film Amour.
Pentecostal Ecclesiologies
Authors: Yong Amos 
Published: July 2018

Abstract
What can be said about ‘pentecostal ecclesiology’ when there are arguably many ‘pentecostalisms’ and just as many ecclesial forms across the world of pentecostal-charismatic Christianity? This chapter provides a basic sketch of such phenomenological diversity and then moves to present as a viable candidate for pentecostal ecclesiological reflection a pneumatological framework of the church as renewed by the Spirit and always renewing. The first section provides some historical perspective on the classical pentecostal movement The second and third sections argue that pentecostal ecclesiological dynamism is inspired largely by its pneumatic spirituality; they map emerging ecclesiological tendencies under the rubrics ‘the church as the charismatic fellowship of the Spirit’ and ‘the church as the people of God, the body of Christ, and the temple of the Holy Spirit’. While the former reflects some of the renewal distinctives about pentecostal ecclesiological self-understanding, the latter situates the pentecostal understanding of the church within the mainstream of ecclesiological developments.
The Shape of the Pauline Churches
Authors: Adams Edward 
Published: July 2018

Abstract
This chapter considers what the Pauline epistles reveal about the nature of the Pauline churches and to this end looks at a range of issues: their genus; their formation; their composition; how Paul configures their identity; their leadership structure; their rituals; their meetings; the kinds of places in which they met. The discussion reflects the state of contemporary scholarship on the Pauline communities, but it also seeks to make a fresh contribution to the subject. A critique of the now dominant ‘house-church’ reconstruction of the Pauline congregations is offered, and a more diversified picture is proposed.
African Ecclesiologies
Authors: Chu Ilo Stan 
Published: July 2018

Abstract
This chapter examines the key issues in scholarship on the identity and mission of the Christian church in Africa, while also exploring in depth the identity of the Roman Catholic Church in Africa. First, the chapter discusses the methodological questions in scholarship in this area, while highlighting the types and models of African ecclesiology in general. Second, it historicizes the narrative of the church in Africa, showing the theological trajectories of scholarship on ecclesia in Africa in the Roman Catholic tradition. Finally, it briefly surveys the key themes being developed in African Catholic ecclesiology from the Second Vatican Council (1962–5) to the Second African Synod (2009). It concludes with a thematic account of how the priorities and practices of the church of Christ are being enacted in the mission of the church in Africa with regard to the challenges facing the Christian faith there.
Karl Barth
Authors: Bender Kimlyn 
Published: July 2018

Abstract
Karl Barth’s ecclesiology is marked by a deeply Christological character set within a Trinitarian context. While the emphasis of Barth’s early ecclesiology was primarily critical in nature and exhibited stark apocalyptic contrasts, his mature ecclesiology moved in ever more Christological, constructive, and analogical directions while not abandoning its highly dialectical and eschatological qualities. Barth’s mature ecclesiology is characterized by an emphasis upon the covenantal unity of Christ with his church grounded in an eternal election, upon the inalienable distinction and asymmetrical relation that ever remains between them, and upon church’s calling by the Holy Spirit and ordained task of witness. This witness is not a repetition or extension of the perfect and complete work of Christ but the commission to proclaim this perfect work and to live a life of correspondence to it, all for the sake of a watching world.
Edges and Interactions beyond Europe
Authors: Sweeney Naoíse Mac , Wells Peter S. 
Published: July 2018

Abstract
Iron Age Europe, once studied as a relatively closed, coherent continent, is being seen increasingly as a dynamic part of the much larger, interconnected world. Interactions, direct and indirect, with communities in Asia, Africa, and, by the end of the first millennium AD, North America, had significant effects on the peoples of Iron Age Europe. In the Near East and Egypt, and much later in the North Atlantic, the interactions can be linked directly to historically documented peoples and their rulers, while in temperate Europe the evidence is exclusively archaeological until the very end of the prehistoric Iron Age. The evidence attests to often long-distance interactions and their effects in regard to the movement of peoples, and the introduction into Europe of raw materials, crafted objects, styles, motifs, and cultural practices, as well as the ideas that accompanied them.
Society of Behavioral Medicine position statement: Society of Behavioral Medicine supports oral cancer early detection by all healthcare providers
Authors: Peterson Caryn E , Gordon Sara C , Le Hew Charles W , Dykens J A , Jefferson Gina D , Tampi Malavika P , Urquhart Olivia , Lingen Mark , Watson Karriem S , Buscemi Joanna , Fitzgibbon Marian L 
Published: July 2018

Abstract
In response to the increasing incidence of certain oral and oropharyngeal cancers, the Society of Behavioral Medicine (SBM) calls on healthcare providers and legislators to expand awareness of oral and oropharyngeal cancer risk factors, increase early detection, and support policies that increase utilization of dental services. SBM supports the American Dental Association’s 2017 guideline for evaluating potentially malignant oral cavity disorders and makes the following recommendations to healthcare providers and legislators. We encourage healthcare providers and healthcare systems to treat oral exams as a routine part of patient examination; communicate to patients about oral/oropharyngeal cancers and risk factors; encourage HPV vaccination for appropriate patients based on recommendations from the Advisory Committee on Immunization Practices; support avoidance of tobacco use and reduction of alcohol consumption; and follow the current recommendations for evaluating potentially malignant oral cavity lesions. Because greater evidence is needed to inform practice guidelines in the primary care setting, we call for more research in collaborative health and dental services. We encourage legislators to support policies that expand Medicaid to cover adult dental services, increase Medicaid reimbursement for dental services, and require dental care under any modification of, or replacement of, the Affordable Care Act.
Unraveling the role of aurora A beyond centrosomes and spindle assembly: implications in muscle differentiation
Authors: Dhanasekaran Karthigeyan , Bose Arnab , Rao Vinay J. , Boopathi Ramachandran , Shankar Shilpa Rani , Rao Vinay Kumar , Swaminathan Amrutha , Vasudevan Madavan , Taneja Reshma , Kundu Tapas K. 
Published: July 2018

ABSTRACTAurora kinases are critical mitotic serine/threonine kinases and are often implicated in tumorigenesis. Recent studies of the interphase functions for aurora kinase (Aurk)A have considerably expanded our understanding of its role beyond mitosis. To identify the unknown targets of AurkA, we used peptide array‐based screening and found E2F4 to be a novel substrate. Phosphorylation of E2F4 by AurkA at Ser75 regulates its DNA binding and subcellular localization. Because E2F4 plays an important role in skeletal muscle differentiation, we attempted to gain insight into E2F4 phosphorylation in this context. We observed that a block in E2F4 phosphorylation retained it better within the nucleus and inhibited muscle differentiation. RNA sequencing analysis revealed a perturbation of the gene network involved in the process of muscle differentiation and mitochondrial biogenesis. Collectively, our findings establish a novel role of AurkA in the process of skeletal muscle differentiation.—Dhanasekaran, K., Bose, A., Rao, V. J., Boopathi, R., Shankar, S. R., Rao, V. K., Swaminathan, A., Vasudevan, M., Taneja, R., Kundu, T. K. Unravelling the role of aurora A beyond centrosomes and spindle assembly: implications in muscle differentiation. FASEB J. 33, 219–230 (2019). www.fasebj.org
Adverse Events After Concurrent Procedures for Gynecologic Malignancies and Pelvic Floor Disorders
Authors: Bretschneider C. Emi , Sheyn David , Mahajan Sangeeta T. , Ferrando Cecile A. 
Published: July 2018

OBJECTIVE:
To evaluate the incidence and trends of 30-day outcomes after concurrent surgeries for gynecologic cancer and pelvic floor disorders.

METHODS:
Using the American College of Surgeons National Quality Improvement Program database, patients who underwent surgery for gynecologic cancer with and without pelvic floor reconstruction were identified between the years 2013 and 2016. Propensity score matching was performed to ameliorate selection. Student t test and Mann-Whitney tests were used to compare continuous variables between two groups where appropriate. The χ2 and Fisher exact tests were used where appropriate to compare categorical variables across groups. Logistic regression models were used to evaluate factors associated with any adverse event and with postoperative transfusion specifically.

RESULTS:
Twenty-five thousand one hundred thirty-eight patients underwent oncologic surgery and 589 (2.3%) of these had concurrent pelvic reconstruction during the study period. After propensity matching, there were 488 combined cases; 976 oncologic-only cases were selected as controls. There were no statistically significant differences across any of the baseline characteristics between groups. Although more common in the combined than in the control cohort, the incidence of any postoperative adverse event (8.2% vs 5.5%, odds ratio [OR] 1.5, 95% CI 0.99–2.3) was not statistically significant between groups. Postoperative blood transfusions, however, were more common in the combined cohort than in the control cohort (7.2% vs 3.6%, OR 1.7, 95% CI 1.1–2.8). After logistic regression, ovarian cancer (adjusted OR 7.9, 95% CI 4.9–12.7) and prolapse surgery (adjusted OR 1.7, 95% CI 1.0–2.7) remained significantly associated with any postoperative adverse events. Similarly, ovarian cancer (adjusted OR 10.0, 95% CI 5.9–17.3) and prolapse surgery (adjusted OR 2.1, 95% CI 1.2–3.6) remained significantly associated with a higher incidence of postoperative blood transfusions.

CONCLUSION:
Combined reconstructive and oncologic surgery is associated with a low but statistically significant increase in the risk of any postoperative adverse event and specifically blood transfusions.