bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and properties of asphalt concrete with various plastic waste in dry processed
Authors: Pamungkas RA , Bagaskara C , Prabanto BA , Rahmat AN , Pambayun WB , Anggoro YS , Setyawan A 
Published: October 2019

Abstract
Plastic is a waste that cannot be decomposed easily, plastic need about a ten to hundreds years to be decomposed perfectly depends on the plastic type. According to CNN, Indonesia is a second largest plastic waste contributor after China with more than 1 million in a minute, 50 percent are just single use then throw away and 5 percent are the truly recycle plastic waste. Along with the current development, there are a lot of innovations to the all things, one of them is substitute the aggregate with plastic, in this thing, plastic will substitute the aggregate pass the ¾ aggregate filters and strained the number 4 aggregate filter substitute with LDPE, PP and PET Plastic each. This research is aimed for evaluating and comparing the effect of adding or substitute the aggregate with LDPE, PP and PET plastics type for designing asphalt concrete. There are four test that related to strength and durability of Asphalt Cocrete: Unconfined Compressive Strength (UCS), Indirect Tensile Strength (ITS) test, Cantabro test, and Permeability test, each of them has a value and each of test will be comparing the specimen test whose aggregate is substitute on LDPE, PP and PET. The result of this research show that in the UCS test PP miture speciment test can hold the vertical pressure 253.41% stronger than PET and 399.12% stronger than LDPE. In ITS test PP mix object 56.29% stronger than PET and 396.90% stronger than LDPE. In the Cantabro test PP mix has durability 1.33% better than PET and 1.60% better than LDPE and in the Permeability test PP has a better classification to be the Asphalt Concrete Wearing Course with Practically Impervious classification.
The Physical and Mechanical Properties of Ethylene Vinyl Acetate Modified Binder
Authors: Setyawan A , Sistra M D , Sarwono D , Djumari  , Zulfadly  
Published: October 2019

Abstract
During its service life, road pavement can easily crack, perforated or deformed. These damages happen as a result of low quality asphalt which indicated by its penetration index and stiffness value. 60/70 penetration asphalt modified by EVA polymer is expected to increase penetration index and stiffness value. Some experiments in the laboratory were carried out based on specified requirements and SNI-2011 asphalt testing procedures. The solid EVA was mixed with the liquid asphalt pen 60/70 at a medium to high temperature until it reaches 250 °C. During the mixing, this mixture was stirred for approximately ±15 minutes until homogeneous. These experiments consist of ductility test, penetration test, softening point test, flash point test, fire point test, specific gravity test, lose on heating test and asphalt stickiness to aggregate test. From the experiment, it can be concluded that the addition of 3.5% EVA in the asphalt pen 60/70 is generally acceptable based on the ductility value of SNI-2011 qualification. The addition of 3.5% give the ductility value of 130 cm, flash point of 300 °C, fire point of 310 °C, softening point of 54 °C, specific gravity of 1.020 gr/cc, asphalt stickiness to aggregate of 100% covered, and lose on heating of 0.037%. Nevertheless the experiment results in penetration value of 37.27 which doesn’t conform the qualification of asphalt pen 60/70. This penetration value resulting in penetration index value of -0.9. This shows that the asphalt resist to the temperature changing. Theoretical predictions of asphalt characteristics using BANDS 2.0 showed that the addition of EVA can increase the penetration index and the stiffness of the bitumen.
The development of Student Attandance System using RFID and Internet of Things (IoT) technology
Authors: Safi’ie M A , Hartono R , Pratama G 
Published: October 2019

Abstract
The attandance of student in the classroom is reflecting their academic performance, the Department of Informatics Engineering in the Universitas Sebelas Maret used a manual way to record student attendance. The manual way is using papers to record student attendance and lecture activities, it may suffer to human error, because attandee can manipulate their presence and the departments can’t monitor them. Radio Frequency Identification (RFID) can be applied to identify various things, because it has unique information codes saved in a special chip called tags. RFID can be applied to developed an attendance system prototype. The term of Internet of Things (IoT) can be described as an embedded system with internet data exchange, by using this technology we can monitored and controlled the devices, also we can integrate the database. The aim of this research is to measure the data speed of the prototype of RFID attendance system, the prototype has function to stored, process, and record the student attendance in the Department of Informatics Engineering.
Smart Energy Meter based on Arduino and Internet of Things
Authors: Yoeseph N M , Safi’ie M A , Purnomo F A 
Published: October 2019

Abstract
Energy meter is a measuring instrument to calculate the amound of electric energy consumed by an electrically powered device. The energy metering which measure line voltage, current, and calculating active power can be used to increase usage efficiency of electricity. This paper presets a system which provide real time energy meter reading using ACS712 as current sensor, ZMPT101B as voltage sensor, arduino and an IoT server. The energy meter can display consumed energy in kWh and electricity bills to be paid. system’s user interface is in Android. the error in current measurement is less than 2 % and error for peak to peak voltage measurement is 4 %. A notification for the amount of electricity energy usage or electricity cost can be generated for user to be displayed.
Bound state energies of a diatomic quantum dot molecule in a magnetic field
Authors: Ma’arif M , Suparmi A , Cari C 
Published: October 2019

Abstract
We investigate energy levels of a diatomic quantum dot by using an analytical method. We use Schrodinger equation for spherical quantum dot molecule in the presence of a static magnetic field and a confining potential which is Morse potential. We obtain the ground state and the excited states eigen solutions which are compared with the experimental data.
Flood damage reduction benefits and costs in Louisiana’s 2017 Coastal Master Plan
Authors: Fischbach Jordan R , Johnson David R , Groves David G 
Published: October 2019

Abstract
The State of Louisiana faces a substantial planning challenge in addressing the joint problems of rapid coastal land loss and storm surge flood risk, exacerbated by rising sea levels and land subsidence. To address these twin challenges, Louisiana has developed a series of coastwide master plans that include substantial investments in coastal restoration and hurricane flood risk reduction, with the most recent update in 2017 that includes about $50 billion in projects to be implemented over 50 years (approximately 2016–2065). This research builds on the integrated modeling analysis conducted in support of Louisiana’s 2017 Coastal Master Plan. We use the Coastal Louisiana Risk Assessment (CLARA) model to project coastal flood damage over time under different scenarios, either in a future without action or with the master plan implemented according to its intended schedule. Analysis results suggest positive, notable benefits from risk reduction investments over a range of assumptions about future conditions and economic considerations. We estimate a 50-year net economic benefit from master plan risk reduction investments of $39.6 to $59.8 billion (benefit-cost ratios of 3.0 to 4.1) across several future scenarios with a 3% assumed discount rate, for instance. Scenarios with higher sea level rise (SLR) and coastal subsidence rates generally yield greater net economic benefit from flood risk reduction investments. Net benefit from risk reduction investments is negative only with the highest discount rate assumption (7%) and if costs are somewhat higher than initially estimated for structural or nonstructural projects. In general, implementing the master plan could yield considerable net economic benefit from damage reduction investment for coastal Louisiana in many plausible future scenarios if implemented as planned.
Novel strain analysis informs about injury susceptibility of the corpus callosum to repeated impacts
Authors: Champagne Allen A , Peponoulas Emile , Terem Itamar , Ross Andrew , Tayebi Maryam , Chen Yining , Coverdale Nicole S , Nielsen Poul M F , Wang Alan , Shim Vickie , Holdsworth Samantha J , Cook Douglas J 
Published: October 2019

Abstract
Increasing evidence for the cumulative effects of head trauma on structural integrity of the brain has emphasized the need to understand the relationship between tissue mechanic properties and injury susceptibility. Here, diffusion tensor imaging, helmet accelerometers and amplified magnetic resonance imaging were combined to gather insight about the region-specific vulnerability of the corpus callosum to microstructural changes in white-matter integrity upon exposure to sub-concussive impacts. A total of 33 male Canadian football players (meanage = 20.3 ± 1.4 years) were assessed at three time points during a football season (baseline pre-season, mid-season and post-season). The athletes were split into a LOW (N = 16) and HIGH (N = 17) exposure group based on the frequency of sub-concussive impacts sustained on a per-session basis, measured using the helmet-mounted accelerometers. Longitudinal decreases in fractional anisotropy were observed in anterior and posterior regions of the corpus callosum (average cluster size = 40.0 ± 4.4 voxels; P &lt; 0.05, corrected) for athletes from the HIGH exposure group. These results suggest that the white-matter tract may be vulnerable to repetitive sub-concussive collisions sustained over the course of a football season. Using these findings as a basis for further investigation, a novel exploratory analysis of strain derived from sub-voxel motion of brain tissues in response to cardiac impulses was developed using amplified magnetic resonance imaging. This approach revealed specific differences in strain (and thus possibly stiffness) along the white-matter tract (P &lt; 0.0001) suggesting a possible signature relationship between changes in white-matter integrity and tissue mechanical properties. In light of these findings, additional information about the viscoelastic behaviour of white-matter tissues may be imperative in elucidating the mechanisms responsible for region-specific differences in injury susceptibility observed, for instance, through changes in microstructural integrity following exposure to sub-concussive head impacts.
Tradeoff between Default Risk and Efficiency Loss
Authors: Lee Jin Hyung 
Published: October 2019

Abstract
The study characterizes an equilibrium bid function with three bidders in an average bid auction (ABA), where a winning bid is the one closest to an average of all submitted bids, when a cost overrun can occur, and an insolvent winner is penalized. First of all, every bidder bids an identical amount in the absence of the penalty. Meanwhile, when the penalty is charged high enough to prevent all bidders from breaching the contract due to cost overruns, either some bidders bid identically and the rest follow a strictly increasing bidding strategy, or all bidders place an identical bid. Based on the characterization, the ABA is compared to the first price reverse auction (FPA) in terms of a buyer’s benefit. The ABA could be more beneficial to the buyer without any penalty in spite of an insolvent winner’s default. If nobody defaults on his bid due to the high penalty, however, the FPA is good to the buyer. This result partly explains the rationale for the ABA in Italy. (JEL codes: C78, D82)
Oral vs Intravenous Antibiotics for Patients With Klebsiella pneumoniae Liver Abscess: A Randomized, Controlled Noninferiority Study
Authors: Molton James S , Chan Monica , Kalimuddin Shirin , Oon Jolene , Young Barnaby E , Low Jenny G , Salada Brenda M A , Lee Tau Hong , Wijaya Limin , Fisher Dale A , Izharuddin Ezlyn , Koh Tse Hsien , Teo Jeanette W P , Krishnan Prabha Unny , Tan Bien Peng , Woon Winston W L , Ding Ying , Wei Yuan , Phillips Rachel , Moorakonda Rajesh , Yuen Kah Hung , Cher Boon Piang , Yoong Joanne , Lye David C , Archuleta Sophia 
Published: October 2019

Abstract

Background
Klebsiella pneumoniae liver abscess (KLA) is emerging worldwide due to hypermucoviscous strains with a propensity for metastatic infection. Treatment includes drainage and prolonged intravenous antibiotics. We aimed to determine whether oral antibiotics were noninferior to continued intravenous antibiotics for KLA.

Methods
This noninferiority, parallel group, randomized, clinical trial recruited hospitalized adults with liver abscess and K. pneumoniae isolated from blood or abscess fluid who had received ≤7 days of effective antibiotics at 3 sites in Singapore. Patients were randomized 1:1 to oral (ciprofloxacin) or intravenous (ceftriaxone) antibiotics for 28 days. If day 28 clinical response criteria were not met, further oral antibiotics were prescribed until clinical response was met. The primary endpoint was clinical cure assessed at week 12 and included a composite of absence of fever in the preceding week, C-reactive protein &lt;20 mg/L, and reduction in abscess size. A noninferiority margin of 12% was used.

Results
Between November 2013 and October 2017, 152 patients (mean age, 58.7 years; 25.7% women) were recruited, following a median 5 days of effective intravenous antibiotics. A total of 106 (69.7%) underwent abscess drainage; 71/74 (95.9%) randomized to oral antibiotics met the primary endpoint compared with 72/78 (92.3%) randomized to intravenous antibiotics (risk difference, 3.6%; 2-sided 95% confidence interval, −4.9% to 12.8%). Effects were consistent in the per-protocol population. Nonfatal serious adverse events occurred in 12/72 (16.7%) in the oral group and 13/77 (16.9%) in the intravenous group.

Conclusions
Oral antibiotics were noninferior to intravenous antibiotics for the early treatment of KLA.

Clinical Trials Registration
NCT01723150.
Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue
Authors: Lemme Marta , Braren Ingke , Prondzynski Maksymilian , Aksehirlioglu Bülent , Ulmer Bärbel M , Schulze Mirja L , Ismaili Djemail , Meyer Christian , Hansen Arne , Christ Torsten , Lemoine Marc D , Eschenhagen Thomas 
Published: October 2019

AbstractAimsChronic tachypacing is commonly used in animals to induce cardiac dysfunction and to study mechanisms of heart failure and arrhythmogenesis. Human induced pluripotent stem cells (hiPSC) may replace animal models to overcome species differences and ethical problems. Here, 3D engineered heart tissue (EHT) was used to investigate the effect of chronic tachypacing on hiPSC-cardiomyocytes (hiPSC-CMs).Methods and resultsTo avoid cell toxicity by electrical pacing, we developed an optogenetic approach. EHTs were transduced with lentivirus expressing channelrhodopsin-2 (H134R) and stimulated by 15 s bursts of blue light pulses (0.3 mW/mm2, 30 ms, 3 Hz) separated by 15 s without pacing for 3 weeks. Chronic optical tachypacing did not affect contractile peak force, but induced faster contraction kinetics, shorter action potentials, and shorter effective refractory periods. This electrical remodelling increased vulnerability to tachycardia episodes upon electrical burst pacing. Lower calsequestrin 2 protein levels, faster diastolic depolarization (DD) and efficacy of JTV-519 (46% at 1 µmol/L) to terminate tachycardia indicate alterations of Ca2+ handling being part of the underlying mechanism. However, other antiarrhythmic compounds like flecainide (69% at 1 µmol/L) and E-4031 (100% at 1 µmol/L) were also effective, but not ivabradine (1 µmol/L) or SEA0400 (10 µmol/L).ConclusionWe demonstrated a high vulnerability to tachycardia of optically tachypaced hiPSC-CMs in EHT and the effective termination by ryanodine receptor stabilization, sodium or hERG potassium channel inhibition. This new model might serve as a preclinical tool to test antiarrhythmic drugs increasing the insight in treating ventricular tachycardia.
Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease
Authors: Li Yang , Yan Han , Guo Jian , Han Yingchun , Zhang Cuifang , Liu Xiuying , Du Jie , Tian Xiao-Li 
Published: October 2019

Abstract

Aims
Genetic contribution to coronary artery disease (CAD) remains largely unillustrated. Although transcriptomic profiles have identified dozens of genes that are differentially expressed in normal and atherosclerotic vessels, whether those genes are genetically associated with CAD remains to be determined. Here, we combined genetic association studies, transcriptome profiles and in vitro and in vivo functional experiments to identify novel susceptibility genes for CAD.

Methods and results
Through an integrative analysis of transcriptome profiles with genome-wide association studies for CAD, we obtained 18 candidate genes and selected one representative single nucleotide polymorphism (SNP) for each gene for multi-centred validations. We identified an intragenic SNP, rs1056515 in RGS5 gene (odds ratio = 1.17, 95% confidence interval =1.10–1.24, P = 3.72 × 10−8) associated with CAD at genome-wide significance. Rare genetic variants in linkage disequilibrium with rs1056515 were identified in CAD patients leading to a decreased expression of RGS5. The decreased expression was also observed in atherosclerotic vessels and endothelial cells treated by various cardiovascular risk factors. Through siRNA knockdown and adenoviral overexpression, we further showed that RGS5 regulated endothelial inflammation, vascular remodelling, as well as canonical NF-κB signalling activation. Moreover, CXCL12, a specific downstream target of the non-canonical NF-κB pathway, was strongly affected by RGS5. However, the p100 processing, a well-documented marker for non-canonical NF-κB pathway activation, was not altered, suggesting an existence of a novel mechanism by which RGS5 regulates CXCL12.

Conclusions
We identified RGS5 as a novel susceptibility gene for CAD and showed that the decreased expression of RGS5 impaired endothelial cell function and functionally contributed to atherosclerosis through a variety of molecular mechanisms. How RGS5 regulates the expression of CXCL12 needs further studies.
Effusion and coin shadow: is there a relation? A case report
Authors: Mohamed Ahmed Mohsen 
Published: October 2019

Abstract

Background
Malignant pericardial effusion is a common consequence of various types of cancer. The diagnosis of cardiac tamponade in malignant effusion may be challenging, as the typical echocardiographic signs are not met. Patients with cancer can present with cardiac tamponade in form of tachycardia (rather that hypotension) that improves after pericardiocentesis.

Case summary
A 70-year-old female patient presented to the emergency department with rapid development of shortness of breath over a week. Her past medical history included oesophageal carcinoma 1 year before presentation. This was complicated by dysphagia for which the patient underwent oesophageal stenting 5 months before admission. On admission, the patient was in respiratory distress, tachycardia; however, she was normotensive. Echocardiography revealed massive circumferential pericardial effusion. Apart from significant respiratory variation in mitral and tricuspid inflow, the echocardiographic features of tamponade were absent. We discuss on how we applied European Society of Cardiology guidelines in order to calculate the pericardiocentesis score and make a firm management plan. Despite that the patient was normotensive, the pericardiocentesis score was 13.5, so urgent pericardiocentesis was done followed by immediate improvement.

Discussion
This case demonstrates that oncology patients can present with tamponade in the form of tachycardia rather than hypotension as the slow course of effusion formation allows the body to compensate by increasing the heart rate and peripheral vascular resistance, thus maintaining the blood pressure. The application of ‘pericardiocentesis score’ is very helpful in such patients. Score equal or greater than 6 necessitates urgent pericardiocentesis even if the blood pressure is normal.
A case report of a late left atrial appendage perforation 4 months after occluder implant: reason for or caused by a resuscitation?
Authors: Schenke Karsten , Geidel Stephan , Keller Christian , Grönefeld Gerian 
Published: October 2019

Abstract

Background
Atrial fibrillation (AF) is a common disease and can lead to cardioembolic stroke. Stroke prevention according to the CHA2DS2VASc score is achieved via oral anticoagulation. In recent years, interventional occlusion of the left atrial appendage (LAA) has become a common alternative. Besides showing non-inferiority in large trials compared with warfarin interventional LAA occlusion can lead to serious adverse events with most of them occurring peri-interventionally.

Case summary
A 75-year-old man with AF and recurrent gastrointestinal bleedings was referred for an interventional closure of the LAA. The intervention was successful with an ABBOTT® Amulet device. Four months later, the patient had to be resuscitated. Return of spontaneous circulation occurred after 10 min. On hospital arrival, echocardiography revealed a pericardial tamponade and 2 L of blood were drained. A coronary angiogram revealed a lesion with active leakage of contrast agent in the proximal circumflex artery. The patient was transferred to the cardiac surgery department immediately. Intra-operatively a perforation of the tissue at the basis of the LAA close to the left main coronary artery was discovered. The occluder was excised and the LAA was closed by endocardial sutures.

Discussion
In this report, we review the literature concerning interventional LAA occlusion and the reported cases of LAA perforation. Retrospectively, it remains unclear whether the perforation caused the resuscitation or was induced by it. To our knowledge, this is the first reported case of a laceration of a coronary artery by an occlusion device.