bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Section Thickness on Heat Transfer during Quenching in Vegetable Oils
Authors: Nayak U. V. , Prabhu K. N. 
Published: September 2018

Abstract
In the present work, mineral, sunflower, karanja, and neem oil were used as quench media. 304 stainless steel probes with diameters of 25 mm and 50 mm were quenched in these oils to assess the effect of section diameter on heat transfer during quenching. Cooling curve analysis was carried out by instrumenting the probes at various locations with thermocouples. The heat extraction ability of oil quench media was quantified using an inverse heat conduction method. Thermal data and the predicted hardness values showed the suitability of nonedible vegetable oils as potential quenchants to heat treat steels. The predicted hardness was higher during quenching in karanja oil compared to other oil media.
Hemofilik artropatinin direk grafi ve manyetik rezonans görüntüleme ile değerlendirilmesi
Authors: ERTAN Gülhan 
Published: September 2018

Amaç: Bu çalışmada hemofilik artropatinin radyolojik değerlendirilmesind, direkt grafi ve manyetik rezonans görüntülemesi karşılaştırılmıştır. Gereç ve Yöntem: Toplam 23 erkek hemofili A hastasında, 109 eklemde hemofilik artropatinin direkt grafi ve manyetik rezonans görüntüleme bulguları kıyaslandı. İki yöntem uyumu kappa istatistiği ile değerlendirildi. Bulgular: Manyetik rezonans görüntülemede efüzyon 17, hemartroz 48, kartilaj kaybı 29, osteonekroz 30, kopmuş parça 3 eklemde izlendi. Direkt grafileri normaldi. Direkt grafide osteoporoz 16, epifizyal genişleme 16, subkondral yüzey düzensizliği 30, eklem aralıklarında daralma 28, eklem ilişki bozukluğu 2, eklem deformitesi 7 eklemde izlenirken, manyetik rezonans görüntülemeleri normaldi. Direkt grafide erozyon olan 3 eklemde, manyetik rezonans görüntüleme negatifti. Direkt grafi ile manyetik rezonans görüntüleme arasında erozyon ve sinovyal hipertrofi değerlendirmesinde zayıf, subkondral kist için orta düzeyde uyum vardı. Sonuç: Hemofili hastalarında manyetik rezonans görüntüleme, eklem içi efüzyon/hemartrozu, sinovyal hipertrofiyi, kartilaj kaybını, erozyon/subkondral kistleri, osteonekrozu ve kopmuş parçayı değerlendirmede direkt grafi’ye bariz üstündür. Manyetik rezonans görüntülemenin özellikle sinovyal hipertrofi ve hemartrozu saptamadaki duyarlılığı, profilaksi yapılacak hastaları belirlemede ve sinovektomi kararı almada kullanımını kaçınılmaz kılmaktadır.
DESIGN OF PROTOTYPE OF KRA ISTHMUS OTOP CENTER
Authors: Umpawan Thidima 
Published: September 2018

Objective:The design of OTOP exhibition centre was aimed to study the background and local lifestyle of people in Kra Isthmus, Ranong Province and OTOP exhibition centre design for Kra Isthmus to increase the value of community shop’s appearance in accordance with Thailand 4.0 policy which aims to promote Thailand’s economy to be an innovation-driven economy.
Methodology:Both qualitative and quantitative methods are used to conduct this study. The background and local lifestyle of the people at Kra Isthmus were studied by using the conceptual framework of ThidimaUmpawan.The survey was conducted with the participation between researcher and people from the community. Three models were created.
1st Prototype was Fon Pad Dad Si (eight months of rain and four months of sunshine) is interior design keyword. 2nd Prototype was Thammadha (normal) and 3rd Prototype was Tuk-mai (wooded shophouses). The design detail of each model consisted of location, organization management, behavior analysis of service provider and service consumer, correlation analysis, image, color schematic, material management, floor plan and other related plans, and perspective.
Main Findings:The results from expert’s opinions on the all models showed that the appropriateness of the location was at the high level ( = 3.80 , SD = 0.60) as well as the organization management ( = 3.70 , SD = 0.65). The third model had the highest score among the three models in floor planning and merchandising ( = 3.45 ,SD = 0.62).Moreover, the third model could well represent lifestyle of Kra Isthmus( = 3.50, SD=0.60) and use appropriate material ( = 3.70 , SD = 0.52). The color schematic of the second and third models was at the average level( = 2.80 , SD = 0.60). The first model had the highest score in lighting design ( =3.20 , SD =0.50) at the average level. For the overall design, the third model had the highest score ( = 3.30 , SD = 0.62).
Implications: As modern agriculture focuses on the management, interior design and technology, modern community shops are established. People in the community become the entrepreneurs who plant, process and sell their own products. Having unique style shop is one way to develop Kra Isthmus area to be Ranong’s cultural tourism area.
3rd International Research conference on Ecotourism & Environment (Souvenier)
Authors: Dubey Ashwani Kumar 
Published: September 2018

Object: To provide a platform to Vice Chancellors, Educational Administrators, College Principals, Deans, Professors, Readers, Associate Professors, Assistant Professors, Scientists, Environmentalist, Researchers, Young scientists and Post Graduate Students to disseminate knowledge related to Ecotourism & Environment.
Theme: To take some positive steps towards improving our Ecotourism & Environment for future generation.
Goal: The moral obligation to act sustainably as an obligation to protect the natural processes that form the context of human life and culture, emphasizing those large biotic and abiotic systems essential to human life, health, and flourishing culture. Ecotourism and Environment, which are understood as dynamic, self-organizing systems humans have evolved within, must remain 'healthy' if humans are to thrive. The principal goal of this conference will be to present some of the latest outstanding breakthroughs in Ecotourism and Environment, to bring together both young and experienced scientists from all regions of the world, and to open up avenues for research collaborations at regional and global level.
The general topics covered in conference will be as under:
Ecotourism is a form of tourism involving visiting fragile, pristine, and relatively undisturbed natural areas, intended as a low-impact and often small scale alternative to standard commercial mass tourism. Ecosystem: Aquatic, Terrestrial and Areal ecosystem, Ecology, Ecosystem and its conservation measure. Wildlife: Animal Behavior and Wildlife Conservation, Endangered, Threatened and Endemic Species Conservation, Strategy for wildlife conservation.
National and World Heritage: Heritage and Tourism, Importance of tourist, Tourist need, Eco-Tourism.
Technological Approach for sustainable development: Method and Technique for Ecotourism and Environment management, Bio-indicator, Application of bio-technology, Rural bio-technology, Tools and technique, Bio-markers, Climate change and Ecosystem management. Role of N.G.O. for Ecotourism, Environment, Wildlife and Heritage conservation
The general topics covered in the conference: Research Needs in Ecotourism, Research Needs in Environment conservation, Action plane for Ecotourism and Environment, Policy in Ecotourism and Environment conservation, Sustainable Ecotourism Development, Guide and Ecotourism, Role of NGO in Ecotourism, Community based Ecotourism, Role of Biodiversity in Ecotourism, Needs of Stakeholders for Ecotourism, International and National Heritage conservation, Assessment of Environmental impacts of Ecotourism, The Existing Knowledge of Ecotourism, Biological and Ecological Impact of Tourism, Pollution in Tourism area, Environmental study of Tourism area, Natural resource management, Wildlife and Forest conservation, Technological Approach Lab to Land.
Pengaruh Model Simulasi Dalam Bimbingan Kelompok Terhadap Disiplin Diri Peserta Didik Kelas XI
Authors: Hanim Wirda , Herdi Herdi , Aminah Siti 
Published: September 2018

Penelitian ini bertujuan untuk mengetahui pengaruh model simulasi dalam bimbingan kelompok terhadap disiplin diri di kelas XI SMK Negeri 26 Jakarta. Sampel penelitian berjumlah 20 responden yang dipilih menggunakan purposive sampling sesuai tujuan yang akan dicapai peneliti, yang terdiri dari 10 orang pada kelompok eksperimen dan 10 orang pada kelompok kontrol. Penelitian menggunakan metode kuasi eksperimen, Nonequivalent Control Group Design. Pengumpulan data menggunakan instrumen disiplin diri. Analisis yang digunakan adalah analisis Mann Whitney U test, yang bertujuan menguji pengaruh hasil kelompok eksperimen dan kelompok kontrol. Hasil analisis yang didapatkan H0 ditolak dan H1 diterima, dengan nilai sig=0.000, hal ini menunjukan probabilitas lebih kecil dari nilai signifikansi α=0.05. Hasil penelitian menunjukan rata-rata skor disiplin diri peserta didik yang mendapatkan bimbingan kelompok dengan menggunakan model simulasi lebih besar dibandingkan rata-rata peningkatan disiplin diri peserta didik yang tidak mendapatkan bimbingan kelompok dengan menggunakan model simulasi.

Kata Kunci: Model Simulasi, Bimbingan Kelompok, Disiplin Diri.
The Influence of Study-Abroad Experiences On Chinese College EFL Teacher’s Identity
Authors: Zhao Yan , Mantero Miguel 
Published: September 2018

The purpose of this study was to explore how in-service Chinese college English teachers produce and reproduce their identities within their study-abroad experiences in terms of their beliefs and classroom practice. Sociocultural theory, discourse theory, and activity theory were used in the theoretical framework to analyze how participants modified their self-perception and changed their classroom practice in different contexts during boundary crossing. The study invited four in-service Chinese college English teachers who took part in three-month study-abroad program. Data were collected from interviews, observations, and document analysis. The findings indicated that participants shifted their self-perception from advanced language user to basic language learner when they studied abroad and had difficulty in dealing with daily tasks. With deeper involvement in the U.S. American culture, they gained more confidence in teaching. After they returned, they were more creative and critical teachers. The findings also demonstrated that participants wanted to implement the latest pedagogies, activities, and management into their own classrooms based on their students’ needs and levels in the Chinese sociocultural context. Although participants encountered challenges in implementation due to students’ levels, learning habits, and local context, they made some effective changes and formed new authority in the classroom. This study suggests that in order to improve study-abroad programs into truly beneficial professional development for teachers, college teachers need to have a clear self-evaluation process, and institutional administrators and foreign directors of study-abroad programs need to stand in teachers’ shoes to meet their requirements. This, in turn, will bring more Chinese college English teachers to study abroad for professional development.
Removal of organic matter from wastewater using M/Al-pillared clays (M = Fe or Mn) as coagulants
Authors: Gouttal Khadidja , Benghalem Abderrezak , Mimanne Goussem , Karim Benhabib 
Published: September 2018

Abstract
This work is about organic matter removal from Sidi Bel Abbes wastewater plant (Algeria) by coagulation on pillared clays (PILCs) under pH and PZC (point of zero charge), conditions. Two pillared clays, M/Al-PILCs (M = Fe or Mn), were synthesized, characterized, and studied as coagulants. Results showed that Fe/Al-pillared clay exhibits superior efficiency, with 18% higher removal rate than the common coagulants alum (AS) and ferric chloride (FCl), and that sedimentation time has positive effect on turbidity removal, with 95.85% removal rate during 30 min. Moreover PILCs will not cause pH go down too low, which is an advantage for achieving the best overall treatment. The IR and UV bands' reduction reveals the breakdown fragmentation of high molecular weight organic substances into smaller units. The highest total organic carbon (supercritical water oxidation analysis) and chemical oxygen demand adsorption capacities (48.52% and 61.85% respectively) obtained for Fe/Al-PILC can be related to increased basal spacing between adjacent layers, creating favorable adsorption sites in the microporous system. The suggested adsorption mechanism involves strong interactions between pollutants and PILCs leading to PILC–pollutant complex formation.
β-caryophyllene Delivery Systems: Enhancing the Oral Pharmacokinetic and Stability
Authors: Santos Pauline S. , Oliveira Thaisa C. , R. Júnior Luís Mário , Figueiras Ana , Nunes Lívio C.C. 
Published: September 2018

Background:
The β-caryophyllene (BCP), a phytocannabinoid present in various essential oils, demonstrated
selective action on the CB2 endocannabinoid receptor and attracted considerable attention because of its
several pharmacological activities. Despite this recognized potential, this hydrophobic compound is a volatile and
acid-sensitive sesquiterpene that readily oxidizes when exposed to air, and has low bioavailability in oral formulations.
Thus, the development of formulations that guarantee its stability and increase its bioavailability is a challenge
for its use in the pharmaceutical field.

Methods:
The present review brings for the first time a comprehensive overview of the controlled and vectorized
release formulations tested for BCP administration. Among these, we have addressed nanoemulsions, inclusion
complexes with cyclodextrins, liposomes, wound dressings, nanocomposites and nanoparticles. A literature
search was performed on Pubmed, Web of Science and Science direct, and patents documents were also searched
on European Patent Office, World Intellectual Property Organization and Brazilian National Institute of Industrial
Property.

Results:
The systems presented here may represent an interesting approach to overcome the limitations already
mentioned for this terpene. These systems proved to be promising for improving solubility, stability and controlled
release of this pharmacological relevant sesquiterpene. In the industrial field, some companies have filed
patent applications for the commercial use of the BCP, however, the use of pharmaceutical formulations still
appeared moderate.

Conclusion:
This prospective study evidenced the new perspectives related to BCP vectorization systems in the
pharmaceutical and industrial marketing field and may serve as a basis for further research and pharmaceutical
use of this powerful cannabinoid.
Serum Interleukin-33 as a Biomarker in Predicting Neonatal Sepsis in Premature Infants
Authors: Halil Halit , Tayman Cuneyt , Buyuktiryaki Mehmet , Okur Nilufer , Cakır Ufuk , Serkant Utku 
Published: September 2018

Background:
Neonatal sepsis is considered as the most frequent cause of death in
newborns. Early diagnosis is important to reduce mortality and morbidity. The rapid progression of
the disease requires proper use of biomarkers specific for prompt diagnosis and intervention.

Objective:
We aimed to evaluate the benefit of interleukin-33 serum levels in the diagnosis and
treatment of neonatal sepsis.

Method:
We included 51 infants with neonatal sepsis as the main study group and 50 neonates
without sepsis as the control group. Serum levels of interleukin-6, interleukin-33 and C-reactive
protein were measured on the 1st, 3rd and 7th days of sepsis in the study group and on the 3rd
postpartum day in the control group, respectively.

Results:
Serum levels of interleukin-6, interleukin-33 and C-reactive protein were significantly higher
in the first day of sepsis. Serum levels of interleukin-6, interleukin-33 and C-reactive protein decreased
significantly on the 3rd and the 7th days of antibiotic treatment. We found a significant relationship
between interleukin-33 and C-reactive protein and between interleukin-6 and C-reactive protein on
the first day of sepsis.

Conclusion:
Serum interleukin-33 level is up-regulated in neonatal sepsis, which might be used as a
novel diagnostic marker and also a useful tool to predict prognosis in early neonatal sepsis.
Event-related Potentials Improve the Efficiency of Cerebrospinal Fluid Biomarkers for Differential Diagnosis of Alzheimer’s Disease
Authors: Leko Mirjana Babić , Skorić Magdalena Krbot , Klepac Nataša , Borovečki Fran , Horvat Lea Langer , Vogrinc Željka , Sonicki Zdenko , Hof Patrick R. , Šimić Goran 
Published: September 2018

Introduction:
The pathological process of Alzheimer's disease (AD) in the brain likely begins
20-30 years earlier than the emergence of its first clinical symptoms and symptoms of AD often overlap
with the symptoms of other primary causes of dementia. Therefore, it is crucially important to improve
early and differential diagnosis of the disease. Event-related potentials (ERP) measured non-invasively
by electroencephalography have shown diagnostic potential in AD.

Aims:

The aim of this study was to compare the efficiency of P300 and N200 potentials and reaction
time (RT) with commonly used protein biomarkers measured in the cerebrospinal fluid (CSF), including
amyloid β peptide (β1-42), total tau (t-tau), tau protein phosphorylated at threonine 181 (p-tau181), tau
protein phosphorylated at serine 199 (p-tau199), tau protein phosphorylated at threonine 231 (p-tau231),
and visinin-like protein 1 (VILIP-1) in differential diagnosis of AD in mild cognitive impairment (MCI)
and AD patients.

Subjects:

The study involved 49 AD patients, 28 patients with MCI, 4 healthy control subjects and 16
patients with other primary causes of dementia.

Results:
ERP (P300RT, N200RT, P300 counting and N200 counting) showed a moderate to strong correlation
with protein CSF biomarkers. We confirmed previous observations of moderate to strong correlation
between ERP and neuropsychological testing and showed that P300 latency and RT are shortened
in AD patients on therapy with acetylcholinesterase inhibitors. Using ERP and RT, a predictive model
for determination of AD likelihood in MCI patients was developed, detecting 56.3% of MCI patients
with high risk for development of AD in our cohort. MCI patients with pathological levels of Aβ1-42 had
prolonged P300 latency, indicating that a combination of ERP and CSF protein biomarkers could improve
the differential diagnosis of AD in MCI patients. Additionally, the results suggested the potential
of P300 latency in differentiating AD and FTD patients.

Conclusion:
Our data provide possible solutions for improvement of differential diagnosis of AD, and
reveal that the diagnostic efficiency of CSF protein biomarkers t-tau, p-tau181, p-tau199, p-tau231 and
VILIP-1 could be improved by adding ERP in clinical practice.
Ligand-Based Drug Design: Synthesis and Biological Evaluation of Substituted Benzoin Derivatives as Potential Antitumor Agents
Authors: Sabbah Dima A. , Ibrahim Ameerah H. , Talib Wamidh H. , Alqaisi Khalid M. , Sweidan Kamal , Bardaweel Sanaa K. , Sheikha Ghassan A. , Zhong Haizhen A. , Al-Shalabi Eveen , Khalaf Reema A. , Mubarak Mohammad S. 
Published: September 2018

Background:
Phosphoinositide 3-kinase α (PI3Kα) has emerged as a promising target
for anticancer drug design.

Objectives:
Target compounds were designed to investigate the effect of the p-OCH3 motifs on
ligand/PI3Kα complex interaction and antiproliferative activity.

Methods:
Synthesis of the proposed compounds, biological examination tests against human colon
adenocarcinoma (HCT-116), breast adenocarcinoma (MCF-7), and breast carcinoma (T47D) cell
lines, along with Glide docking studies.

Results:
A series of 1,2-bis(4-methoxyphenyl)-2-oxoethyl benzoates was synthesized and characterized
by means of FT-IR, 1H and 13C NMR, and by elemental analysis. Biological investigation
demonstrated that the newly synthesized compounds exhibit antiproliferative activity in human colon
adenocarcinoma (HCT-116), breast adenocarcinoma (MCF-7), and breast carcinoma (T47D)
cell lines possibly via inhibition of PI3Kα and estrogen receptor alpha (ERα). Additionally, results
revealed that these compounds exert selective inhibitory activity, induce apoptosis, and suppress
VEGF production. Compound 3c exhibited promising antiproliferative activity in HCT-116 interrogating
that hydrogen bond-acceptor mediates ligand/PI3Kα complex formation on m- position.
Compounds 3e and 3i displayed high inhibitory activity in MCF-7 and T47D implying a wide cleft
discloses the o-attachment. Furthermore, compound 3g exerted selective inhibitory activity against
T47D. Glide docking studies against PI3Kα and ERα demonstrated that the series accommodate
binding to PI3Kα and/or ERα.

Conclusion:
The series exhibited a potential antitumor activity in human carcinoma cell lines encoding
PI3Kα and/or ERα.
Silimarin and Cancer
Authors: Liakopoulou Christina , Kazazis Christos , Vallianou Natalia G. 
Published: September 2018

Background:
Silimarin is the dry mixture of a whole family of natural substances, extracted after the
addition of ethanol, methanol, and acetone. Silimarin consists mainly of silibin A and silibin B, as well as other less
important compounds.

Methods:
Silimarin has been demonstrated to “inhibit cell proliferation and to induce apoptosis, while also having
anti-angiogenic properties.” The induction of apoptosis in cancer cells has been mediated by the involvement of ER
stress.

Results:
Silibinin has the potential to operate as a STAT3-targeted inhibitor as well as an inhibitor of the upregulation
of the immune checkpoint regulator PD-L1 and also EMT regulators, thus being a promising adjuvant in
NSCLC. It has also been documented to suppress cancer cells be means of down- regulating actin cytoskeleton and
PI3K / Akt molecular pathways. Several studies have demonstrated that silibinin exerts its protective potential partly
through interacting with the tumor suppressor gene p53.

Conclusions:
It is noteworthy that research has been carried out on the enhancement of silimarin’s bioavailability,
especially by the preparation of specific nanoformulas, and its probable additional use together with the chemotherapeutic
regimens in the near future.