bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Intermittent Fasting In Starving Cancer Cells
Authors: Sakina Sakina , Meher A. , Nath Ravi N. , Rahman T. 
Published: November 2024

Introduction. An absolute burden of over 35 million new cancer cases is predicted by 2050. Although significant progress has been made in the field of oncology via the use of surgical removal, radiation treatment, chemotherapy, and the introduction of immunotherapy, the overall rates of survival and prognoses for cancer patients are still unsatisfactory. In the last decade, intermittent fasting (IF) has become increasingly popular for weight control and potential health benefits. Additionally, research has primarily focused on investigating the impact of IF on metabolism, mitochondrial function, stress responses, repair mechanisms, and autophagy.
The aim of the study. To make a literature review about the role of intermittent fasting in starving cancer cells.
Materials and methods. This narrative review involved a comprehensive search through databases such as PubMed and Google Scholar. Distinct keywords such as - ″intermittent fasting″, ″intermittent fasting regimens″, ″calorie restriction″, ″oncology″, ″chemotherapy″ and ″tumor microenvironment″ were used.
Results. IF exhibits significant impacts on the immune system's ability to fight against tumors by strengthening the ability of hematopoietic stem cells to replenish themselves and enhance immunosuppression. Under an IF program, certain tissues and organs exhibit enhanced resilience to various stressors. Emerging research shows that IF has the potential to enhance the effectiveness and tolerance of anticancer medicines, regulate carcinogenic influences, reprogram clock genes' rhythmic expression in tumor environments, inhibit tumor growth by modifying natural processes like insulin signalling, heme oxygenase-1, prevent the proliferation of myeloid-derived suppressor cells and priming the tumor microenvironment to support drug delivery that targets tumors. Cancer treatment via IF notably shields normal cells while raising the efficacy of chemotherapy (CT) and reducing CT-induced inflammation via several immunological, biochemical, and molecular mechanisms.
Conclusions. Regularly practising fasting for more than one day may confer notable health benefits by protecting healthy normal cells against the deleterious effects of chemotherapy and radiation. The synergistic therapeutic impact of intermittent fasting alongside chemotherapy on tumors suggests that it enhances the efficacy of chemotherapy while also notably reducing chemotherapy-induced inflammation. While intermittent fasting shows promise for certain cancers, such as breast cancer, its efficacy for other types remains uncertain, necessitating further research and personalized treatment plans.
Income Inequality Prevalence and Health Indicators: Implication For Economic Growth in Nigeria
Authors: Abiodun Lawal Nurudeen , Adegbola Omobolanle , Oluwasegun Okikiola Samuel 
Published: November 2024

This study explores the income inequality prevalence and health indicators implication for Nigeria economic growth between 1980 and 2022 using the Auto Regressive Distributive Lag Model. Time series secondary data on health indicators (life expectancy and infant mortality rate), Gini coefficient, economic growth and unemployment rate were sourced from the World Development Indicator Database. The Bounds test's F-statistics revealed that health indicators, income inequality, and unemployment rate have long-run relationship with economic growth in Nigeria. The ARDL estimation result shows that in the short run, income inequality and unemployment rate jointly affect economic growth while unemployment reduced national productivity in Nigeria. However, in the long run, there is a more encompassing effect of unemployment rate in the Nigerian economy. The results shows that the interactive role of unemployment and infant mortality in stimulating economic growth in Nigeria is evident, so when unemployment rate decrease, same as infant mortality, it automatically stimulates economic growth in Nigeria. Income inequality shows a negative relationship with economic growth which implies that it is a statistically significant variable that reduces the economic growth of Nigeria. This study therefore recommends that there should be proper plan, design, and implementation measures to reduce income inequality by targeting social and economic policies that promote equitable distribution of resources and opportunities. In addition, access to quality healthcare should be enhanced by increasing investment in healthcare infrastructure and expansion of health services in the nation. More importantly, creation of streams of income for the unemployed should be targeted, and policies to combat unemployment should be developed par time.
Formation and evolution of the Party Ideology of the Russian Social Democrats/Bolsheviks as the basis of the future state ideology of the Country of Soviets
Authors: Fokin Andrei Vladimirovich 
Published: November 2024

The subject of this study is the process of formation of the party ideology of the RSDLP from the moment of its institutionalization at the end of the XIX century until the seizure of power by the Bolsheviks in October 1917. The subject of the study is those aspects of the Bolshevik worldview that later formed the basis of the ideology of the Soviet state. Special attention is paid to Lenin's understanding of ideology as a class worldview of the proletariat, proposed by the "vanguard" of this class - the Russian Social Democratic Workers' Party. The author pays great attention to the class attitudes of the leader of the Russian Social Democrats, V. I. Lenin, because they had a key impact on the formation of the Bolshevik ideology. The novelty of the research lies in the author's approach, which combines the principles of historicism and scientific objectivity with a class understanding of the essence of ideology, on which the development of the party ideology of the RSDLP was based. This allows us to analyze the logic of V. I. Lenin's theoretical constructions, to understand his personal worldview,. which, due to the authority of the party leader, was transformed, first into a party ideology, and then into a state one. The author comes to the following conclusions: the class approach predetermined the basic principles of the formation of the ideology of the Russian Social Democrats/Bolsheviks. Perceiving the class worldview as a kind of monolith based on the relation of property to the means of production, the party leader developed a coherent picture of the world, which changed only when political conditions transformed: when the socialist revolution seemed to be a matter of an uncertain future, and when, in the conditions of the world war, its implementation became temporally tangible. It was the presence of a clearly defined ideology, which was shared by the majority of the Bolsheviks, that allowed them to take power into their own hands during the revolution.
European legislation on public control: problems and prospects of development
Authors: Cheshin Andrei Vladimirovich , Goncharov Vitalii Viktorovich , Malinovskii Oleg Nikolaevich , Petrenko Elena Gennad'evna 
Published: November 2024

This article is devoted to the analysis of modern problems of the development of European legislation on public control. The authors explore the current state and stages of development of European legislation, which forms the basis of public control in the European Union. It is noted that the term "public control" is generally unfamiliar with the legal terminology of both European legislation and the legislation of countries that are members of the European Union. The terminology uses the terms "transparency" and "participation". At the same time, transparency refers to the accessibility and openness of both the authorities of the European Union and the member states. And participation should be understood as the ability of civil society institutions to participate in decision-making of the European Union, to interact with its institutions, for example, through dialogue through civil society organizations of which they are members. The work uses a number of methods of scientific cognition, in particular: formal-logical; comparative-legal; historical-legal; statistical; sociological; method of analyzing specific legal situations. The paper identifies, formalizes and investigates the main problems that hinder the development of the institution of public control in the European Union, in particular, the lack of at the level of the European Union, a single codified act of the constitutional level; the lack of consolidation in European legislation of a direct indication of the right of institutions (subjects) of civil society to exercise control over the European bureaucracy and public authorities of national states members of the European Union, as well as other entities exercising certain public powers on the territory of the European Union (for example, European non-governmental organizations); the lack of the legal doctrine of civil society and its control of comprehensive studies devoted to the analysis of forms, methods, principles, types and forms of activities of the above-mentioned control of civil society; in civil society entities a set of real powers to control the European bureaucracy; consolidation in European legislation of a system of measures of criminal liability of officials of the European bureaucracy for ignoring the requirements of civil society institutions or obstructing their legitimate activities; specialized subjects of the above-mentioned control of civil society.
Substantiation of the discharge mode of electrohydraulic equipment for drilling destruction of monolithic objects
Authors: Barsukov V. O. 
Published: November 2024

Introduction. The article raises the problems associated with electrohydraulic drilling destruction of oversized monolithic objects, which are found, in particular, on the territory of construction works. At the moment, there is no assessment of the technology effectiveness, which means that methods are needed to justify the optimal discharge mode and its reproducibility in industrial equipment. The purpose of the article is substantiation of optimal energy parameters for destructing monolithic objects by using electrohydraulic drilling method. Materials and methods. The analysis of factors contributing to electrohydraulic fracture of monolithic objects was carried out and the most significant ones were identified. It is proposed to characterize the discharge mode with a set of parameters related to the transitional processes at the moments of conductor destruction, the discharge duration and the amount of energy input. Сalculation of the parameters has been presented in this paper. Results and discussions. Based on the identified active factors, a stand for registration the electrohydraulic effect has been developed. Parameters for ensuring reproducibility of the discharge mode are derived depending on the change in the discharge circuit inductance. Practical implications are proposed based on data analysis. Conclusion. The research findings advance a simple experiment planning to evaluate technology effectiveness. The article will be of interest to researchers in the field of electrohydraulic and electropulse technologies, and practitioners involved in clearing territories and removing monolithic objects.
Dependence of the soils’ elastic modulus reinforced with inorganic binders on compressive strength
Authors: Slobodchikova N. A. , Klyuev S. V. , Plyuta K. V. 
Published: November 2024

Introduction. The modulus of elasticity refers to one of the main physical and mechanical characteristics of reinforced local grounds. Deformations of soils and building materials are usually described by Hooke’s law. The main laboratory testing methods include applying of uniaxial compression, triaxial compression, rigid stamp technics. Determining the modulus of elasticity is a complex, time-consuming and labor-intensive test. There are empirical models that describe the relationship between the modulus of elasticity and various parameters and characteristics (compressive strength, binder content in the mixture, etc.). However, these models are mainly developed for stabilized soils and for crushed stone reinforced with Portland cement. Methods and materials. To determine the pattern of change in the modulus of soils’ elasticity reinforced with inorganic binding materials from compressive strength, studies were conducted on samples of various soils strengthened with Portland cement and lime. Existing methods specified in the regulatory and technical documentation were used to produce the samples. Results. Based on the performed research, two empirical models were developed that reflect the dependence of the elastic modulus values on the compressive strength values of soils reinforced with Portland cement and lime. Discussion and conclusions. Existing testing methods of the elastic modulus are lengthy and labor-intensive. The developed empirical models allow us to obtain approximate values of the elastic modulus from the values of compressive strength of soil samples reinforced with Portland cement and lime.
ФОРМУВАННЯ ПРОДУКТОВОЇ СТРАТЕГІЇ ЯК ГОЛОВНОГО ЕЛЕМЕНТА МАРКЕТИНГОВОЇ ТОВАРНОЇ ПОЛІТИКИ
Authors: Лялюк Алла , Дригуля Микола 
Published: November 2024

Introduction. Today, when the target market changes, competition increases or the marketing environment changes, the nature and pace of product development must also change. Different markets and competitive situations require different product development cycle lengths, degrees of standardization and support services. All of the above requires a rethinking of the role of marketing product policy, in particular marketing product strategy.
The purpose of the article.To investigate the essence of the product strategy, the peculiarities of product marketing, to analyze the foreign experience of forming a product strategy and to build a model of the company's product marketing strategy.
Metods. The use of the method of analysis and synthesis of foreign experience in the formation of product marketing made it possible to adapt the model of the company's product marketing strategy to domestic realities.
Results A product strategy sets the direction for the business, unites everyone around common goals and reduces waste. Product marketers spend a lot of time solving problems – many of which could be avoided if product goals, priorities and strategies were clear and aligned. In order to better understand who should do what, a model of the company's marketing product strategy is proposed, which includes three components: a strategy for determining product activity (initial activity); product manufacturing strategy (input activity) and sales strategy (output activity).
Conclusiоns The structure of product marketing and its functioning depends on the size of the enterprise, the markets in which it operates, as well as the skills and preferences of the people involved. However, in order to achieve success, it is necessary to realize three aspects: decide who and what should be done; understand who is ultimately responsible for the success of each product; a detailed understanding of existing and potential customers and markets. Knowing this helps ensure products are well positioned, customers want to buy them, and sales teams have what they need to sell.
ОСОБЛИВОСТІ ВНУТРІШНЬОГО КОНТРОЛЮ РОЗРАХУНКІВ ПІДПРИЄМСТВА В УМОВАХ ВОЄННОГО СТАНУ
Authors: Талах Тетяна 
Published: November 2024

Introduction. In the conditions of martial law, enterprises face new challenges that affect all areas of their economic activity, including settlement operations. Internal control of settlements becomes critical for ensuring financial stability and supporting operational activities. This requires a study of the specifics of the organization of internal control of the company's calculations during the state of war, in particular the issue of ensuring the security of financial operations in conditions of instability and market uncertainty.
The purpose of the article. The purpose of the study is to investigate the features and effective mechanisms of internal control of payments at enterprises operating under martial law to ensure their financial stability and competitiveness.
Methods. The research methodology includes a comprehensive approach that combines general scientific methods: analysis, synthesis, comparison, as well as specific financial and economic methods of evaluating the internal control system, including methods of risk analysis and auditing of financial operations.
Results. The article examines the main principles of ensuring effective internal control of the calculations of economic entities in the conditions of martial law. It was found that failures in the work of banking systems, interruptions in communications and logistics significantly complicate the timely execution of financial transactions. The need to strengthen control over payment discipline on the part of both the enterprise and its counterparties has been identified. The necessity of implementing additional measures to protect the payment system, including increased attention to the verification of counterparties and the use of digital monitoring tools, has been proven. The growing need for rapid adaptation of internal control procedures to new conditions, such as changes in legislation introduced in connection with military operations, or new requirements for financial reporting, which requires the involvement of qualified personnel capable of promptly responding to new challenges and risks, has been studied.
Conclusions. It has been proven that the internal control of the company's calculations in the conditions of martial law is an important element of maintaining stable operations and financial security. Therefore, to ensure its effectiveness, it is necessary to constantly update control methods, take into account new risks and challenges associated with war, and implement modern monitoring tools on the basis.
Intensification of meat productivity of horses for production of new horse meat products
Authors: Sadykov E. V. , Herman Yu. I. 
Published: November 2024

Prospective tasks for the development of cultural herd horse breeding in Belarus include raising horses of new quality, which are most in demand in the current conditions for use within the republic and for export, as well as intensification of their meat productivity. While bearing specific traits of Belarusian Harness and Russian Heavy Draft breeds, horses of these genotypes will be characterized by new features of non-traditional horse use (cultural herd keeping). It was determined that it would be more expedient to enter both the domestic and foreign markets not with raw materials for processing, but with finished products. This is evidenced by the constantly accumulated domestic experience of meat processing enterprises of the country, including the economic results of meat horse breeding at FE “Vasilek” (Dzerzhinsky district). The paper presents for the first time the information about the developed normative documentation for industrial production of new types of horse meat products (cooked and smoked sausage product, semi-smoked sausage product, dry-cured pastirma) (Collection of recipes, Specifications). In general, the research conducted to study the meat productivity of horses of the studied genotypes kept in cultural herds should be the subject of further scientific research aimed at the development of technology for the production of new high-quality products and semi-finished products from horse meat. The data obtained will be used to develop a system of selection and intensive rearing of young horses of the Belarusian Harness and Russian Heavy Draft breeds characterized by meat-type exterior to achieve optimal early maturity and meat productivity. This will improve the welfare of Belarusian horse breeding, increase the quality of herd horses, and become an export-oriented branch of productive horse breeding for the CIS countries.
Institutional foundations of the modern mechanism of digitalization of agroindustrial complex management
Authors: Takun A. , Gorbatovskaya О. 
Published: November 2024

The regulatory and legal framework in the sphere of digitalization of agroindustrial complex management is analyzed. The system of republican public administration bodies in the context of digital development of agriculture was defined, including two blocks of subjects: public administration in the field of digital development and sectoral management of digital development in the agroindustrial complex.Within the framework of the modern institutional mechanism of digitalization of the agroindustrial complex management, the main subjects, their functions and infrastructural components that provide the necessary conditions for the introduction of information and communication technologies in the agricultural sphere, the implementation of state projects of sectoral digital development, the formation of a network system of interaction and digital technological base of industry management have been established.
Analisis Keaktifan dan Kolaborasi Melalui Pemberian Reward Penerapan Two Stay Two Stray
Authors: Wadi Hairil 
Published: November 2024

Peneliitian ini dilatarbelakangi masih kurangnya pemberian reward oleh guru IPS yang dapat menarik perhatian siswa yang mengaktifkan sekaligus kolaborasi antar siswa sehingga menyebabkan siswa kurang respon dalam aktivitas pembelajaran. Penelitian ini bertujuan menganalis keaktifan dan kolaborasi siswa dalam penerapan Two Stay two stray model melalui pemberian Reward oleh guru Pada mata pelajaran IPS. Metode penelitian menggunakan pendekatan kualitatif metode kasus, dengan teknik pengumpulan data melalui observasi, dan dokumentasi. Subjek penelitian dengan teknik porposive sampling, yaitu guru IPS dan siswa kelas IX A. Analisa data mengikuti analisis kualitatif model Miles and Huberman dengan tahapan reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan:keaktifan dan kolaborasi siswa muncul seperti aktif visual, aktif mental, aktif mendengarkan, aktif lisan, aktif tulisan, kolaborasi tangung jawab, kerja sama, penyelesaian tugas bersama, interaksi sosial dikarenakan adanya reward lisan, tindakan, simbol, benda oleh guru IPS selama diterapkan Two stay two stray model pada mata pelajaran IPS. Kesimpulan dari penelitian ini keaktifan dan kolaborasi siswa dalam penerapan Two Stay two stray model muncul karena adanya pemberian reward oleh guru IPS seperti rewad lisan, reward tindakan, reward simbol dan reward benda.