bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for nonreassuring fetal heart rate tracings after artificial rupture of membranes in spontaneous labor
Authors: Ganer Herman Hadas , Tamayev Liliya , Houli Rotem , Miremberg Hadas , Bar Jacob , Kovo Michal 
Published: April 2018

AbstractBackgroundWe aimed to characterize factors associated with nonreassuring fetal heart (FHR) tracings after artificial rupture of membranes (AROM), during the active phase of labor.MethodsDelivery charts of patients who presented in spontaneous labor, at term, between 2015 and 2016 were reviewed. We identified cases in which AROM was performed during the active stage of labor. We compared deliveries with a normal FHR and those who developed nonreassuring FHR. Nonreassuring FHR was defined as fetal tracing that necessitated intrauterine resuscitation, which included: oxytocin withheld, amnioinfusion, or immediate instrumental or cesarean birth.ResultsOf 664 deliveries, nonreassuring FHR occurred in 141 (21.2%) and normal FHR in 523 (78.7%). Both groups were notable for similar maternal characteristics and a similar gestational age. Epidural block was significantly more common in the nonreassuring FHR group (P < .001), as was meconium during delivery (P = .01). Deliveries in the nonreassuring FHR group were characterized by significantly lower Bishop scores at AROM. Mean birthweight was significantly lower in the nonreassuring FHR group (3201 ± 418 vs 3342 ± 376 g, P < .001), yet, neonatal outcome did not differ between the groups. In a multivariate logistic regression model, nulliparity, AROM at a station lower than −2, and increased birthweight were all significantly associated with a decreased rate of nonreassuring FHR, while prolonged duration from AROM to delivery and oxytocin augmentation significantly increased the risk for nonreassuring FHR.DiscussionNonreassuring FHR after AROM during delivery is associated with parity, fetal station at AROM, birthweight, and oxytocin augmentation.
Midwifery and obstetrics: Factors influencing mothers’ satisfaction with the birth experience
Authors: Mattison Cristina A. , Dion Michelle L. , Lavis John N. , Hutton Eileen K. , Wilson Michael G. 
Published: April 2018

AbstractBackgroundSatisfaction is a key component of the care experience and part of the health system “triple aim,” along with improving population health and reducing per capita health care costs, the other two parts of the “triple aim.” The objectives of the study were to examine birth‐experience satisfaction among women in Ontario, Canada, who received care from midwives, family physicians, and obstetricians.MethodsWe used Statistics Canada's 2006 national Maternity Experiences Survey. The sample includes 1900 Ontario women and is, with appropriate weighting, representative of an estimated population of 29 700 women who gave birth in Ontario to a singleton baby during the study period. Information was collected on respondents’ satisfaction with their health care providers, demographic characteristics, and a range of pregnancy, labor, birth, and postpartum experiences. We used logistic regression analysis to assess differences in patient/client satisfaction by type of health care provider.ResultsWomen cared for by midwives were three times more likely to be satisfied with their care (OR 3.32 [95% CI 2.26‐4.86]) when compared with obstetrician‐led care. Depression symptoms, having to travel outside the respondents’ community to give birth, and being born in an East Asian country were associated with lower levels of satisfaction.ConclusionGiven recent health system reforms emphasizing the importance of shifting from expensive acute hospital‐based care to community‐based care, our findings support empirically the importance of supporting women's access to midwifery services within their communities. Findings of ethnocultural differences in satisfaction with care can inform policy makers as health systems move to provide culturally appropriate care to increasingly diverse populations.
Obstetric interventions, trends, and drivers of change: A 20‐year population‐based study from Iceland
Authors: Swift Emma M. , Tomasson Gunnar , Gottfreðsdóttir Helga , Einarsdóttir Kristjana , Zoega Helga 
Published: April 2018

AbstractBackgroundPopulation data on obstetric interventions is often limited to cesarean delivery. We aimed to provide a more comprehensive overview of trends in use of several common obstetric interventions over the past 2 decades.MethodsThe study was based on nationwide data from the Icelandic Medical Birth Register. Incidence of labor induction, epidural analgesia, cesarean, and instrumental delivery was calculated for all births in 1995‐2014. Change over time was expressed as relative risk (RR), using Poisson regression with 95% confidence intervals (CI) adjusted for several maternal and pregnancy‐related characteristics. Analyses were stratified by women's parity and diagnosis of diabetes or hypertensive disorder.ResultsDuring the study period, there were 81 389 intended vaginal births and 5544 elective cesarean deliveries. Among both primiparous and multiparous women, we observed a marked increase across time for labor induction (RR 1.78 [CI 1.67‐1.91] and RR 1.83 [CI 1.73‐1.93], respectively) and epidural analgesia (RR 1.40 [CI 1.36‐1.45] and RR 1.74 [CI 1.66‐1.83], respectively). A similar trend of smaller magnitude was observed among women with hypertensive disorders but no time trend was observed among women with diabetes. Incidence of cesarean and instrumental delivery remained stable across time.DiscussionThe use of labor induction and epidural analgesia increased considerably over time, while the cesarean delivery rate remained low and stable. Increases in labor induction and epidural analgesia were most pronounced for women without a diagnosis of diabetes or hypertensive disorder and were not explained by maternal characteristics such as advanced age.
Combined somatic mutation and copy number analysis in the survival of familial CLL
Authors: Zhou Weiyin , Goldin Lynn , Wang Mingyi , McMaster Mary L. , Jones Kristine , Burdett Laurie , Chanock Stephen J. , Yeager Meredith , Dean Michael , Caporaso Neil E. 
Published: April 2018

SummaryRecurrent large‐scale somatic copy number alterations (SCNAs), and somatic point mutations can be analysed to stratify patients with chronic lymphocytic leukaemia (CLL) into distinct prognostic groups. To investigate the relationship between SCNAs and somatic mutations, we performed whole‐exome sequencing and single nucleotide polymorphism microarray analyses on 98 CLL patients from 40 families with a high burden of CLL. Overall, 69 somatic mutations in 29 CLL driver genes were detected among 45 subjects (46%), with the most frequently mutated genes being TP53 (8·2%), NOTCH1 (8·2%) and ATM (5·1%). Additionally, 142 SCNAs from 54 subjects (57%) were detected, including losses of chromosome 13q14 (28·9%), 11q (5·6%), 17p (2·1%), and gain of chromosome 12 (4·2%). We found that patients having both an adverse point mutation in a CLL driver gene and an unfavourable SCNA tended to have poorer survival (Hazard ratio [HR] = 3·17, 95% confidence interval [CI] = 0·97–10·35; P = 0·056) than patients having either a point mutation (HR = 1·34, 95%CI = 0·66–2·71; P = 0·42) or SCNAs (HR = 2·65, 95%CI = 0·77–9·13; P = 0·12). TP53 mutation carriers were associated with the poorest overall survival (HR = 4·39, 95%CI = 1·28–15·04; P = 0·018). Our study suggests that combining SCNA and mutational data could contribute to predicting outcome in familial CLL.
Enhanced expression of IFI16 and RIG-I in human third-trimester placentas following HSV-1 infection
Authors: Jabłońska A , Studzińska M , Suski P , Kalinka J , Paradowska E 
Published: April 2018

Summary
The innate immune response in the placenta depends on the ability of maternal immune cells and fetal trophoblast cells to detect and eliminate invading pathogens through germline-encoded pattern recognition receptors (PRRs). In the present study, we analysed the transcripts and protein expression of interferon (IFN)-inducible protein (IFI)16, melanoma differentiation-associated protein 5 (MDA5), RIG-I-like receptor (RIG-I) and Toll-like receptor (TLR)-3 in third-trimester human placentas and investigated cytokine profiles generated during herpes simplex type 1 (HSV-1) infection. Decidual and chorionic villous biopsies (38–42 weeks of gestation) were obtained from healthy women immediately after a caesarean section. The expression of the DDX58 (RIG-I), IFIH1 (MDA5), IFI16 and TLR3 transcripts was measured using quantitative real-time polymerase chain reaction (qRT–PCR). Extracellular cytokine and PRRs levels were then quantified by enzyme-linked immunosorbent assays (ELISAs). All examined PRRs genes, including DDX58, IFIH1, IFI16 and TLR3, were expressed constitutively at the mRNA and protein levels in the placental biopsies. The concentration of the IFI16 protein was increased in HSV-1-infected decidual and chorionic villous explants compared to those of mock-infected tissues (P = 0·029). Higher protein expression levels of RIG-I in both the maternal and fetal parts of the placenta were found (P = 0·009 and P = 0·004, respectively). In addition, increased production of IFN-β by HSV-1-infected tissues was noticed (P = 0·004 for decidua, P = 0·032 for chorionic villi). No significant differences in the IFN-α, interleukin (IL)-6 and IL-8 levels were found. These results showed that HSV-1 infection can enhance the expression of IFI16 and RIG-I proteins in the human term placenta.
Conservation mycology in Australia and the potential role of citizen science
Authors: Irga Peter J. , Barker Katherine , Torpy Fraser R. 
Published: April 2018

AbstractFungi are undoubtedly important for ecosystem functioning; however, they have been omitted or given scant attention in most biodiversity policy documents, management plans, and formal conservation schedules throughout the world. This oversight may be due to a general lack of awareness in the scientific community and compounded by a scarcity of mycology‐associated curricula at the tertiary level and a lack of mycologists in research institutions. Although molecular techniques advance the systematic cataloging of fungi and facilitate insights into fungal communities, the scarcity of professional mycologists in the environmental sciences hampers conservation efforts. Conversely, citizen science initiatives are making significant contributions to the mycology discipline by increasing awareness and extending the scope of fungal surveys. Future research by professional and amateur mycologists into the distribution of fungi and their function in ecosystems will help identify wider and more effective conservation goals.
Young people's experiences of managing Type 1 diabetes at university: a national study of UK university students
Authors: Kellett J. , Sampson M. , Swords F. , Murphy H. R. , Clark A. , Howe A. , Price C. , Datta V. , Myint K. S. 
Published: April 2018

AbstractAimLittle is known about the challenges of transitioning from school to university for young people with Type 1 diabetes. In a national survey, we investigated the impact of entering and attending university on diabetes self‐care in students with Type 1 diabetes in all UK universities.MethodsSome 1865 current UK university students aged 18–24 years with Type 1 diabetes, were invited to complete a structured questionnaire. The association between demographic variables and diabetes variables was assessed using logistic regression models.ResultsIn total, 584 (31%) students from 64 hospitals and 37 university medical practices completed the questionnaire. Some 62% had maintained routine diabetes care with their home team, whereas 32% moved to the university provider. Since starting university, 63% reported harder diabetes management and 44% reported higher HbA1c levels than before university. At university, 52% had frequent hypoglycaemia, 9.6% reported one or more episodes of severe hypoglycaemia and 26% experienced diabetes‐related hospital admissions. Female students and those who changed healthcare provider were approximately twice as likely to report poor glycaemic control, emergency hospital admissions and frequent hypoglycaemia. Females were more likely than males to report stress [odds ratio (OR) 4.78, 95% confidence interval (CI) 3.19–7.16], illness (OR 3.48, 95% CI 2.06–5.87) and weight management issues (OR 3.19, 95% CI 1.99–5.11) as barriers to self‐care. Despite these difficulties, 91% of respondents never or rarely contacted university support services about their diabetes.ConclusionThe study quantifies the high level of risk experienced by students with Type 1 diabetes during the transition to university, in particular, female students and those moving to a new university healthcare provider.
Woody plants optimise stomatal behaviour relative to hydraulic risk
Authors: Anderegg William R. L. , Wolf Adam , Arango‐Velez Adriana , Choat Brendan , Chmura Daniel J. , Jansen Steven , Kolb Thomas , Li Shan , Meinzer Frederick C. , Pita Pilar , Resco de Dios Víctor , Sperry John S. , Wolfe Brett T. , Pacala Stephen 
Published: April 2018

AbstractStomatal response to environmental conditions forms the backbone of all ecosystem and carbon cycle models, but is largely based on empirical relationships. Evolutionary theories of stomatal behaviour are critical for guarding against prediction errors of empirical models under future climates. Longstanding theory holds that stomata maximise fitness by acting to maintain constant marginal water use efficiency over a given time horizon, but a recent evolutionary theory proposes that stomata instead maximise carbon gain minus carbon costs/risk of hydraulic damage. Using data from 34 species that span global forest biomes, we find that the recent carbon‐maximisation optimisation theory is widely supported, revealing that the evolution of stomatal regulation has not been primarily driven by attainment of constant marginal water use efficiency. Optimal control of stomata to manage hydraulic risk is likely to have significant consequences for ecosystem fluxes during drought, which is critical given projected intensification of the global hydrological cycle.
Local provenancing in subtropical rainforest restoration: For better or worse? A review of practitioners’ perspectives
Authors: Cooper Sally L. , Catterall Claudia , Bundock Peter C. 
Published: April 2018

SummaryThe adaptive potential of restored communities is important to their long‐term sustainability, particularly in the face of changing environmental conditions such as climate change. The genetic diversity of rainforest plants in restoration projects and their suitability to current and future environmental site conditions are important considerations for restoration practitioners and seed suppliers. Presented here are the results from a survey of rainforest restoration practitioners in North East New South Wales and South East Queensland, Australia. The survey canvassed practitioners’ perspectives on local provenancing, genetic diversity and other aspects of restoration that have the potential to influence the long‐term success of restored rainforest communities. All respondents to this survey typically included a planting component in their restoration projects (whether for reconstruction or to supplement assisted regeneration). Planting represents an anthropogenic selection and translocation of genotypes to a restoration site. As a result, considerations of genetic origin and the potential implications to the restored rainforest community are relevant to most restoration projects. This industry survey's results showed that genetic diversity and local provenancing are concepts of importance to practitioners. However, there seems to be a lack of clarity within the industry about how to define local provenance and how the concepts of local provenancing and genetic diversity influence each other. The results indicated that local provenancing remains the preferred provenancing strategy amongst practitioners, with inclusion of non‐local provenance seed not regarded as an effective means of improving genetic diversity. This is despite researchers highlighting the limitations of local provenancing, particularly in highly fragmented landscapes, and despite the publication of numerous alternative provenancing strategies. Rainforest restoration may benefit from practitioners questioning the appropriateness of local provenancing to their restoration projects and considering that in some circumstances exclusive reliance on local provenance stock may in fact be worse, not better, for the long‐term sustainability of restored communities.
Corvid interference with Canid Pest Ejectors in the southern rangelands of Western Australia
Authors: Kreplins Tracey L. , Kennedy Malcolm S. , Dundas Shannon J. , Adams Peter J. , Bateman Philip W. , Fleming Patricia A. 
Published: April 2018

SummaryCanid Pest Ejectors (CPE) are a method of population management that has recently been approved for the control of wild dogs and foxes in Australia. A pilot trial of CPEs (n = 10) targeting wild dogs was conducted in the southern rangelands of Western Australia in the winter of 2017. CPEs were deployed for 81 days, which included periods of significant rainfall. CPEs were not serviced during deployment, which is a likely situation for remote areas where access may be limited. During deployment, all ejector units corroded and plastic capsules containing 1080 degraded (but did not leak). For CPEs to remain effective in the field, they require regular inspections and servicing, particularly in wet conditions. Interference by nontarget corvid species was observed. Six CPEs were interfered with by corvids, with the lures removed from three, partially removed from another two and one disassembled. Our data suggest that corvid interference with ejectors may have a significant impact on the efficiency and safety of their use. Further investigation into the usefulness of Canid Pest Ejectors as method of canid control is required for rangeland use.
Trends and values of ‘Land for Wildlife’ programs for private land conservation
Authors: Prado Joshua A. , Puszka Helena , Forman Alexander , Cooke Benjamin , Fitzsimons James A. 
Published: April 2018

SummaryThe Land for Wildlife program started in Victoria in 1981 as a voluntary program with the broad aim of supporting landholders in providing habitat for wildlife on their property. The program has since spread across Australia and is implemented in a range of guises, through a variety of governance approaches. This research collected qualitative and quantitative data on Land for Wildlife programs across Australia to conduct the first national review. Data were gathered on changes in program membership to assess different participation trends. In addition, phone interviews with Land for Wildlife coordinators throughout Australia were conducted to explore how the programs are positioned in delivering biodiversity outcomes in a range of different regions. Over 14,000 properties covering 2.3 million ha are currently registered under Land for Wildlife programs. with at least 500,000 ha of habitat managed for conservation. Limited resources present a large challenge faced by a number of programs, with generally low funding and staffing resulting in restricted biodiversity focus and conservation outcomes. We suggest options to enhance the programs and propose future research directions.
Taking proportionality seriously: The use of contextual integrity for a more informed and transparent analysis in EU data protection law
Authors: Guinchard Audrey 
Published: April 2018

AbstractDifficulties abound as to where the boundary between legitimate and illegitimate processing of personal data should be set. The open‐ended wording of the EU Data Protection Directive (DPD) 95/46 leaves space for diverse interpretations. The European Court of Justice finds it difficult to establish methodically the contextual data flows associated with individuals’ rights and their processing, with cascading consequences for the proportionality analysis, thus echoing the wider debate on proportionality. Taking stock of the criticisms of the ECJ's decisions and of the changes introduced by the General Data Protection Regulation, this paper proposes to use contextual integrity, a framework of analysis developed by Helen Nissenbaum, largely implicit in EU data protection law, to provide a systematic method of interpretation that ensures more consistency in current EU legal practice. It recommends adopting a new formal three‐tier structure, so that all factors necessary to the discussion on proportionality are fully and systematically identified and proportionality is taken seriously.
No Place Like Home? Graduate Migration in Germany
Authors: Haussen Tina , Uebelmesser Silke 
Published: April 2018

AbstractThe aim of this paper is to identify migration patterns of the highly educated, placing special emphasis on imbalances across regions. For this, we use data from a representative and longitudinal graduate survey in Germany with information about the work and migration history during the first 5 years after graduation. With regional funding of higher education, the number of graduates who leave the university region and the resulting net balance matter. It is equally important to understand whether economically weak and strong regions are affected differently and if graduates of study programs which are more or less costly to provide display different migration patterns. The findings show that stronger regions are more attractive for graduates. However, graduates of expensive study fields are less attached to their university region than graduates of inexpensive study fields if the university region has an above‐average GDP per capita. There is no evidence, however, that this also holds for regions with a below‐average GDP per capita. These weaker regions thus face a number effect, but there is no composition effect as far as the fields of study are concerned.
A systematic review of risk of HIV transmission through biting or spitting: implications for policy
Authors: Cresswell FV , Ellis J , Hartley J , Sabin CA , Orkin C , Churchill DR 
Published: April 2018

ObjectivesThe perceived threat of HIV transmission through spitting and biting is evidenced by the increasing use of “spit hoods” by Police Forces in the UK. In addition, a draft parliamentary bill has called for increased penalties for assaults on emergency workers, citing the risk of communicable disease transmission as one justification. We aimed to review literature relating to the risk of HIV transmission through biting or spitting.MethodsA systematic literature search was conducted using Medline, Embase and Northern Lights databases and conference websites using search terms relating to HIV, AIDS, bite, spit and saliva. Inclusion and exclusion criteria were applied to identified citations. We classified plausibility of HIV transmission as low, medium, high or confirmed based on pre‐specified criteria.ResultsA total of 742 abstracts were reviewed, yielding 32 articles for full‐text review and 13 case reports/series after inclusion and exclusion criteria had been applied. There were no reported cases of HIV transmission related to spitting and nine cases identified following a bite, in which the majority occurred between family (six of nine), in fights involving serious wounds (three of nine), or to untrained first‐aiders placing fingers in the mouth of someone having a seizure (two of nine). Only four cases were classified as highly plausible or confirmed transmission. None related to emergency workers and none were in the UK.ConclusionsThere is no risk of transmitting HIV through spitting, and the risk through biting is negligible. Post‐exposure prophylaxis is not indicated after a bite in all but exceptional circumstances. Policies to protect emergency workers should be developed with this evidence in mind.