bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERAN KOMITMEN ORGANISASI DALAM MEMEDIASI PENGARUH VARIABEL KETELADANAN PEMIMPIN, KOMPETENSI PERANGKAT DESA, DAN BUDAYA ORGANISASI TERHADAP KINERJA
Authors: Saputri Eka Dewi , Muhsin Muhsin 
Published: January 2019

Penelitian ini bertujuan untuk mengetahui pengaruh langsung dan tidak langsung antara keteladanan pemimpin, kompetensi perangkat desa, dan budaya organisasi terhadap kinerja perangkat desa melalui komitmen organisasi. Populasi dalam penelitian ini adalah 157 perangkat desa di Kecamatan Pangkah dengan jumlah sampel sebanyak 113 orang dari 23 desa yang dihitung dengan rumus slovin. Metode pengumpulan data dilakukan dengan dokumentasi, kuesioner, observasi, dan wawancara. Metode analisis data penelitian ini menggunakan path analysis dengan signifikansi sebesar 5%. Hasil perhitungan data diperoleh persamaan mediator yang selanjutnya disingkat dengan M = 11,542 - 0,005X1 + 0,164X2 + 0,200X3+ 0,734e1 dan kinerja perangkat desa yang selanjutnya disingkat dengan Y = 11,573 + 0,233X1 + 0,246X2 + 0,084X3 +0,270M + 0,720e2. Hasil penelitian ini menunjukkan bahwa keteladanan pemimpin dan kompetensi perangkat desa berpengaruh positif secara langsung terhadap kinerja perangkat desa. Namun, variabel budaya organisasi dan komitmen organisasi tidak berpengaruh secara langsung terhadap kinerja perangkat desa. Sedangkan variabel kompetensi perangkat desa dan budaya organisasi memiliki pengaruh positif secara tidak langsung melalui komitmen organisasi terhadap kinerja perangkat desa.

This research aimed to determine the direct and indirect influence of leaders’ exemplary, village apparatus’ competence, and organizational culture to the village apparatus’ performance through organizational commitment.The population in this research was 157 village apparatus in Pangkah with 113 samples from 23 villages calculated by Slovin Formula. Data collecting methods were documentation, questionnaire, observation, and interview. The methods of the data analysis of this researchused path analysis with 5 % significance.The result of the data calculation obtained the equation of mediation then shortened as M = 11,542 - 0,005X1 + 0,164X2 + 0,200X3 + 0,734e1 and village apparatus’ performance then shortened as Y = 11,573 + 0,233X1 + 0,246X2 + 0,084X3 + 0,270M + 0,720e2. The results showed that leaders’ exemplary and village apparatus’ competence have a direct positive effect to the village apparatus’ performance. However, the organizational culture and organizational commitment variables did not direct affect the village apparatus’ performance. While the competence variables of village apparatus and organizational culture have a indirect positive influence through organizational commitment to the village apparatus’ performance.
Coverage-Versus-Length Plots, a Simple Quality Control Step for de Novo Yeast Genome Sequence Assemblies
Authors: Douglass Alexander P , O’Brien Caoimhe E , Offei Benjamin , Coughlan Aisling Y , Ortiz-Merino Raúl A , Butler Geraldine , Byrne Kevin P , Wolfe Kenneth H 
Published: January 2019

Abstract
Illumina sequencing has revolutionized yeast genomics, with prices for commercial draft genome sequencing now below $200. The popular SPAdes assembler makes it simple to generate a de novo genome assembly for any yeast species. However, whereas making genome assemblies has become routine, understanding what they contain is still challenging. Here, we show how graphing the information that SPAdes provides about the length and coverage of each scaffold can be used to investigate the nature of an assembly, and to diagnose possible problems. Scaffolds derived from mitochondrial DNA, ribosomal DNA, and yeast plasmids can be identified by their high coverage. Contaminating data, such as cross-contamination from other samples in a multiplex sequencing run, can be identified by its low coverage. Scaffolds derived from the bacteriophage PhiX174 and Lambda DNAs that are frequently used as molecular standards in Illumina protocols can also be detected. Assemblies of yeast genomes with high heterozygosity, such as interspecies hybrids, often contain two types of scaffold: regions of the genome where the two alleles assembled into two separate scaffolds and each has a coverage level C, and regions where the two alleles co-assembled (collapsed) into a single scaffold that has a coverage level 2C. Visualizing the data with Coverage-vs.-Length (CVL) plots, which can be done using Microsoft Excel or Google Sheets, provides a simple method to understand the structure of a genome assembly and detect aberrant scaffolds or contigs. We provide a Python script that allows assemblies to be filtered to remove contaminants identified in CVL plots.
Aromatase Inhibitors and Newly Developed Nonalcoholic Fatty Liver Disease in Postmenopausal Patients with Early Breast Cancer: A Propensity Score-Matched Cohort Study
Authors: Lee Jung Il , Yu Jung-Hwan , Anh Sung Gwe , Lee Hyun Woong , Jeong Joon , Lee Kwan Sik 
Published: January 2019

Abstract

Background
Unlike tamoxifen, the relationship between aromatase inhibitor use in postmenopausal patients with breast cancer and nonalcoholic fatty liver disease (NAFLD) has not been delineated.

Materials and Methods
A retrospective analysis of 253 patients with early breast cancer without baseline NAFLD and treated with nonsteroidal aromatase inhibitors was performed. Among them, 220 patients were matched for sex, age, and menstruation status with healthy patients, and the prevalence of NAFLD was compared. NAFLD was determined by hepatic steatosis index in the absence of other known liver diseases. The presence of significant liver fibrosis in patients with NAFLD was determined noninvasively by AST-platelet ratio index, FIB-4 score, and NAFLD fibrosis score (NFS).

Results
Postmenopausal patients with breast cancer undergoing treatment with aromatase inhibitors had higher prevalence of NAFLD independent of body mass index (BMI) and underlying diabetes mellitus (DM). Although the aromatase inhibitor group showed higher fibrotic burden by NFS, independent of BMI and DM, the proportion of advanced fibrosis did not show statistically significant differences between AI-treated patients and the healthy patients. Those with abnormal baseline fasting glucose levels are suggested to have increased risk of NAFLD development after aromatase inhibitor treatment. In addition, patients with NAFLD developed after aromatase inhibitor use had significantly lower disease-free survival than those without NAFLD, although there was no significant difference in overall survival.

Conclusion
Results of this study suggest that inhibition of estrogen synthesis in postmenopausal women undergoing treatment with aromatase inhibitors could increase the risk of NAFLD, which might have some influence on the prognosis of patients with breast cancer.
Everolimus plus Exemestane for Hormone Receptor-Positive Advanced Breast Cancer: A PAM50 Intrinsic Subtype Analysis of BOLERO-2
Authors: Prat Aleix , Brase Jan Christoph , Cheng Yuan , Nuciforo Paolo , Paré Laia , Pascual Tomás , Martínez Débora , Galván Patricia , Vidal Maria , Adamo Barbara , Hortobagyi Gabriel N. , Baselga José , Ciruelos Eva 
Published: January 2019

Abstract

Background
The prognostic and predictive value of the two nonluminal (human epidermal growth factor receptor 2 [HER2]-enriched and basal-like) subtypes within advanced hormone receptor-positive (HR+) breast cancer is currently unknown.

Materials and Methods
This study retrospectively analyzed 261 tumors (80.7% primary; 19.3% metastatic) from the BOLERO-2 study; BOLERO-2 randomized 724 patients with advanced HR+/HER2-negative breast cancer to everolimus plus exemestane or placebo plus exemestane. Tumors were classified using a PAM50 subtype predictor. Multivariable Cox regression analyses tested the independent prognostic significance of PAM50, and associations between PAM50 subtypes and treatment upon progression-free survival (PFS) were evaluated.

Results
Subtype distribution was 46.7% luminal A (n = 122), 21.5% HER2-enriched (n = 56), 15.7% luminal B (n = 41), 14.2% normal-like (n = 37), and 1.9% basal-like (n = 5); HER2-enriched subtypes were more common in metastatic versus primary tumors (32.0% vs. 18.7%; p = .038). Median PFS differences between luminal and nonluminal (6.7 vs. 5.2 months; adjusted hazard ratio, 0.66; 95% confidence interval [CI], 0.47–0.94; p = .020) and HER2-enriched and non-HER2-enriched subtypes (5.2 vs. 6.2 months; adjusted hazard ratio, 1.53; 95% CI, 1.07–2.19; p = .019) were significant. Everolimus plus exemestane significantly improved median PFS versus placebo plus exemestane among patients with HER2-enriched tumors (5.8 vs. 4.1 months; adjusted hazard ratio, 0.49; 95% CI, 0.26–0.90; p = .034); however, the association between HER2-enriched tumors and everolimus benefit was nonsignificant (p = .433).

Conclusion
The HER2-enriched subtype was identified in a substantial proportion of advanced HR+/HER2-negative breast tumors, and was a consistent biomarker of poor prognosis. Tailored therapies are therefore needed for HER2-enriched tumors in the advanced HR+/HER2-negative breast cancer setting.
MİDHAT CEMAL KUNTAY’IN GARB’A TENKİTLERİ: İFTİRA-YI TAASSUB
Authors: GÜNER Selda 
Published: January 2019

Bu makale, Mithat Cemal Kuntay’ın az bilinen ve dolayısıyla yeni
harflerle yayınlanmamış ve bir Batı tenkidi olan 1911 tarihli İftira-yı Taasub eserinin, takdim ve
teşhirini yapmayı amaçlamaktadır. Ayrıca Osmanlıca yazılmış olan bu risale
bugünkü Türkçe’ye aktarılacaktır. Midhat Cemal’in henüz 28 yaşında iken yazdığı bu risale, yaşlı imparatorluğun genç
kalemlerinden birinin imzasını taşımaktadır. Diğer yandan bu çalışma, metnin
özerkliğini de dikkate alacak ve fakat yazar ve metnin öznelliklerinin muayyen
bir tarihselliğin sınırları tarafından oluşturulduğunu ihmal etmeyecektir.
Öncelikle Midhat Cemal’in Türk edebiyatı tarihindeki yeri, onun şahsi
özellikleri de hesaba katılarak anlatılacaktır. Onun milli hislerini eserlerine
yansıtması belirgin bir özelliğidir. Zira İmparatorluğun çöküş devrine şahitlik
etmiş bir edibin eserlerinde bu hislerin mevcudiyeti şaşırtıcı değildir. İftira-yı Taassubu yazdığı sene,
İmparatorluğun Afrika’daki son toprağı Trablusgarb İtalyanlarca işgal
edilmişti. Akabinde de Balkan savaşları meydana gelecekti. İftira-yı Taasuub, İmparatorluğun zevalinin Türk münevverleri
üzerindeki tesirlerini gösteren örneklerden yalnızca biridir. Ayrıca bu
makalede, doğulu bir aydının Batı’ya yönelttiği eleştiriler dikkate
alınacaktır. Zira bu risale bir oryantalizm eleştirisidir ve Batıda din ve
taassup ilişkisini örnekleriyle açıklamak niyetiyle yazılmıştır.
YÖRÜK “YÖRÜR MÜ?” YÖRÜK KELİMESİNİN ETİMOLOJİSİ ÜZERİNE BİR DENEME
Authors: YİĞİT Hayrettin 
Published: January 2019

Orta Asya’dan yüzyıllar önce ayrılarak
dünyanın dört bir tarafına göç eden Türk boylarından birçoğu, zaman içerisinde
yerleşik hayata geçerken bazı boy ve aşiretler ise konar-göçer yaşamaya devam
etmiştir. Bu konar-göçer hayat tarzını
benimseyen Oğuz boylarının birçoğu Anadolu’da Kızılırmak yayının batısından
İçel’i de içine alan çizginin batısında kalan bölgeler ile Rumeli topraklarına
kadar gelmişler ve yaşamlarını tamamen hayvancılığa bağlı olarak kışın ovalarda
yazın da yaylalarda sürdürmüşlerdir. Anadolu’da konar-göçer bu topluluklara
Yörük-Türkmen adı verilmiştir. Sosyo-kültürel yaşantılarına bağlı olarak
kullanılan yörük kelimesi tarihi
belgelerde 14. yüzyıldan itibaren kullanılmıştır. Kelime Anadolu ağızlarında yogrük, yörügen yörük, yürük, yuvruk, yüğrük,
yürük, yuvrük, yüyrük gibi fonetik değişikliklere uğramıştır. Söyleyiş
farklılıklarından dolayı yörük
kelimesinin köken olarak yorı-, yürük,
yüğrük kelimelerinden hangisinden geldiği tartışmalara neden olmuş ve net
bir sonuca varılmadığı görülmüştür. Makalede bu kelimelerin Türkçenin ilk
eserlerinden itibaren kullanımı ve sözlüklerdeki anlamları verilerek genel bir
kanıya varmak amaçlanmıştır.
Emerging and Reemerging Aedes-Transmitted Arbovirus Infections in the Region of the Americas: Implications for Health Policy
Authors: Espinal Marcos A. , Andrus Jon K. , Jauregui Barbara , Waterman Stephen Hull , Morens David Michael , Santos Jose Ignacio , Horstick Olaf , Francis Lorraine Ayana , Olson Daniel 
Published: January 2019

The increasing geographical spread and disease incidence of arboviral infections are among the greatest public health concerns in the Americas. The region has observed an increasing trend in dengue incidence in the last decades, evolving from low to hyperendemicity. Yellow fever incidence has also intensified in this period, expanding from sylvatic-restricted activity to urban outbreaks. Chikungunya started spreading pandemically in 2005 at an unprecedented pace, reaching the Americas in 2013. The following year, Zika also emerged in the region with an explosive outbreak, carrying devastating congenital abnormalities and neurologic disorders and becoming one of the greatest global health crises in years. The inadequate arbovirus surveillance in the region and the lack of serologic tests to differentiate among viruses poses substantial challenges. The evidence for vector control interventions remains weak. Clinical management remains the mainstay of arboviral disease control. Currently, only yellow fever and dengue vaccines are licensed in the Americas, with several candidate vaccines in clinical trials. The Global Arbovirus Group of Experts provides in this article an overview of progress, challenges, and recommendations on arboviral prevention and control for countries of the Americas.
Police-Related Deaths and Neighborhood Economic and Racial/Ethnic Polarization, United States, 2015–2016
Authors: Feldman Justin M. , Gruskin Sofia , Coull Brent A. , Krieger Nancy 
Published: January 2019

Objectives. To estimate the association between rates of police-related deaths and neighborhood residential segregation (by income, race/ethnicity, or both combined) in the United States. Methods. We identified police-related deaths that occurred in the United States (2015–2016) using a data set from the Guardian newspaper. We used census data to estimate expected police-related death counts for all US census tracts and to calculate the Index of Concentration at the Extremes as a segregation measure. We used multilevel negative binomial models for the analyses. Results. Overall, police-related death rates were highest in neighborhoods with the greatest concentrations of low-income residents (vs high-income residents) and residents of color (vs non-Hispanic White residents). For non-Hispanic Blacks, however, the risk was greater in the quintile of neighborhoods with the highest concentration of non-Hispanic White residents than in certain neighborhoods with relatively higher concentrations of residents of color (the third and fourth quintiles). Conclusions. Neighborhood context matters—beyond individual race/ethnicity—for understanding, preventing, and responding to the occurrence of police-related deaths. Public Health Implications. Efforts to monitor, prevent, and respond to police-related deaths should consider neighborhood context, including levels of segregation by income and race/ethnicity.
Using Animations of Risk Functions to Visualize Trends in US All-Cause and Cause-Specific Mortality, 1968–2016
Authors: Rudolph Jacqueline E. , Cole Stephen R. , Edwards Jessie K. , Whitsel Eric A. , Serre Marc L. , Richardson David B. 
Published: January 2019

Objectives. To use dynamic visualizations of mortality risk functions over both calendar year and age as a way to estimate and visualize patterns in US life spans. Methods. We built 49 synthetic cohorts, 1 per year 1968 to 2016, using National Center for Health Statistics (NCHS) mortality and population data. Within each cohort, we estimated age-specific probabilities of dying from any cause (all-cause analysis) or from a particular cause (cause-specific analysis). We then used Kaplan–Meier (all-cause) or Aalen–Johansen (cause-specific) estimators to obtain risk functions. We illustrated risk functions using time-lapse animations. Results. Median age at death increased from 75 years in 1970 to 83 years in 2015. Risk by age 100 years of cardiovascular mortality decreased (from a risk of 55% in 1970 to 32% in 2015), whereas risk attributable to other (i.e., nonrespiratory and noncardiovascular) causes increased in compensation. Conclusions. Our findings were consistent with the trends published in the NCHS 2015 mortality report, and our dynamic animations added an efficient, interpretable tool for visualizing US mortality trends over age and calendar time.
Talent & Technology: Critical Skills for a Successful Career
Authors: JPT staff _ 
Published: January 2019

Talent & Technology
The recently published LinkedIn “Roadmap,” which utilized data from more than 500 million members combined with a survey of 2,000 business leaders, identified that soft skills are often more needed than hard skills. SPE recognizes that its members need to possess such skills—and more. Recently, the SPE Soft Skills Committee was renamed Business and Management Leadership (BML) to better represent the needs and missions of such skills in successful careers. The BML committee organized a panel session during the 2018 SPE Annual Technical Conference and Exhibition titled “Critical Skills for Career Success” where industry leaders provided their insights on what skills make a difference in one’s career, and how to develop and master critical skills to attain business and management leadership. The moderator of the panel was Maria Capello, Kuwait Oil Company. Panelists were Kamel Ben Naceur, ADNOC; Behrooz Fattahi, The EnerTrain Institute; Ford Brett, PetroSkills; Thomas Blasingame, Texas A&M University; and Janeen Judah, 2017 SPE President.
The key takeaway of the panel was that, no matter your position, entry-level or senior management, you must be able to manage and motivate people. Employers want and need people who can stretch out of their comfort zone and see change as an opportunity for growth and innovation. Having the ability to accept and adapt is important, because adjusting to a new environment is now part of the mod-ern world of working.
Ben Naceur, ADNOC’s chief economist, started the discussion. He has worked in 14 countries and experienced four price cycles in the oil industry, during which he envisioned and empowered his career progression into new roles. His vision grew with every new role, allowing him to understand the importance of soft skills. Ben Naceur started his career in a technical position within an R&D organization, shifting into the applications side of the industry, supervising complex hydraulic fracture stimulations, requiring immediate decision-making and the management of people from very diverse cultural settings. Later, he became Minister for Industry, Energy, and Mines in his home country, Tunisia, a huge responsibility he accepted mainly to be able to give back to his nation. During the panel discussion, he asserted that being able to continuously adapt to new jobs, new cultures, and new languages is of critical importance—and although diverse technical skills were essential for his career, Ben Naceur credits soft skills as the “building bridges” that enabled major course changes.
“People tend to judge you for what they can see but they don’t know what is inside you, and that is precisely the part you need to pay attention to,” said panelist Fattahi, 2010 SPE President. Further, “in the logical plane of your brain, 1 plus 1 is always 2. That’s logic…but not on the emotional plane. We always tend to train for logic but we do not pay attention to the emotional system.”
Optimization Work Flow Converts Power to Performance for GOM Drilling
Authors: Carpenter Chris 
Published: January 2019

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper OTC 29065, “Converting Power to Performance: Gulf of Mexico Examples of an Optimization Work Flow for Bit Selection, Drilling-System Design, and Operation,” by Mark W. Dykstra, SPE, Miguel A. Armenta, SPE, Fitzerald A. Mathew Ain, SPE, Omolara Adesokan, and Tess L. Schornick, Shell, and Ashabikash Roy Chowdhury, SPE, and Mark D. Allain, Baker Hughes, a GE company, prepared for the 2018 Offshore Technology Conference, Houston, 30 April–3 May. The paper has not been peer reviewed. Copyright 2018 Offshore Technology Conference. Reproduced by permission.
Time spent on bottom drilling is only approximately 10% of the time consumed by drilling operations, but this still provides a significant opportunity for savings if it can be reduced. The goal of the work described in this paper was to decrease this percentage while drilling an exploratory well in the Gulf of Mexico. Significant results were achieved with the use of advanced hybrid polycrystalline-diamond-compact/tungsten-carbide-insert (PDC/TCI) bits.
Introduction
The focus well is in the Walker Ridge area approximately 150 nautical miles south of Port Fourchon, Louisiana. The rig floor to the zone of interest includes 6,500 ft of water, 1,200 ft of sediments, 12,250 ft of salt, and then deeper sediments. In the basic well design, a 38-in. conductor would be jetted to 200 ft below the mudline. The 26-in. section would be drilled through sediments and 2,000 ft of salt without risers using seawater and a 9.3-lbm/gal water-based pump-and-dump (PAD) drilling fluid, after which the 22-in. casing would be set. The 16½-in. section would be drilled through the bulk of the remaining salt with a riser in place using synthetic-based drilling fluid. The well would remain vertical until the kickoff point. After setting a 14-in. casing, the remaining hole sections would exit the salt and penetrate the deeper zones using synthetic-based drilling fluid.
Design Phase: Offset Well Study
The first step in the optimization process was to evaluate the drilling challenges that could be encountered in each hole section and identify potential performance limiters. The key lessons from the analysis of offset wells include the following:
The shale/sand sequence above the salt would be soft and could be drilled as quickly as desired, though subject to wellbore stability and hole-cleaning limitations.
The salt section would be very drillable, but mechanical specific energy (MSE) levels would be approximately 40 ksi.
PDC bits would be very aggressive, so torque would be highly sensitive to weight on bit (WOB).
Peak rate of penetration (ROP) in both salt and sediments would be directly proportional to the power provided to the bit.
Torque variation could be as low as 10 to 20% for stiff drillstrings featuring 65/8-in. drillpipe using relatively high rotary speeds (e.g., 170 rev/min or greater).
Bottomhole assembly (BHA) designs with a minimal tendency to hang up are desirable.
Polyelectrolyte-Complex Nanoparticles for Fluid-Loss Control in Oilwell Cementing
Authors: Andersen Corbin D. , Lin Ying-Ying , Liang Jenn-Tai 
Published: January 2019

Summary
This paper focuses on the application of polyelectrolyte-complex (PEC) nanoparticles to fluid-loss control of oilwell cements. Cement-slurry design involves considerable complexities, including the interplay of viscosity, yield point (YP), fluid-loss control, setting time, sedimentation, gel-strength development, and density. Polymers such as hydroxyethyl cellulose (HEC), carboxymethyl HEC (CMHEC), and polyvinyl alcohol have been used extensively for fluid-loss control in oilwell cementing. However, the resulting increase in slurry viscosity often led to unwanted side effects, such as increased pumping requirements. PECs were originally developed as drug carriers for pharmaceutical applications. Our previous work (Cordova et al. 2008; Lin et al. 2014; Johnson et al. 2016) showed that they can also be effective in improved-oil-recovery applications. In this study, we explore the potential of using PEC nanoparticles to achieve effective fluid-loss control while maintaining good fluid properties of the cement slurry. Results from this proof-of-concept study demonstrated that a PEC system comprising common oilfield polymers can be used to achieve effective fluid-loss control. Simultaneously, the system shows improved rheological properties over control samples while maintaining other desirable slurry characteristics.