bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le world café comme outil de mobilisation pour la sensibilisation à la maltraitance envers les proches aidants à Québec
Authors: Éthier Sophie , Côté Anne-Sophie 
Published: February 2019

La provenance de la maltraitance envers les aînés est le plus souvent attribuée à leur entourage et expliquée par le stress de l’aidant ou les relations antérieures conflictuelles ou abusives. Cet article vise à mettre en lumière une problématique sociale méconnue : la maltraitance envers les proches aidants. Nous exposons la démarche et les résultats d’un « world café » organisé à Québec pour en discuter. Cet exercice de consultation collective suscite quelques pistes de réflexion. D’abord, l’impossibilité de dissocier la maltraitance envers les aidants de celle des aînés, tout en soulignant l’importance de lui réserver un traitement différencié. Aussi, l’absence d’évaluation de leurs besoins par les intervenants, dont les travailleurs sociaux, ainsi que le manque de reconnaissance et de soutien des aidants de la part de l’État comme facteurs de développement d’un terreau fertile à la maltraitance.
Salvianolic acid B plays an anti-obesity role in high fat diet-induced obese mice by regulating the expression of mRNA, circRNA, and lncRNA
Authors: An Tian , Zhang Jing , Lv Bohan , Liu Yufei , Huang Jiangpinghao , Lian Juan , Wu Yanxiang , Gao Sihua , Jiang Guangjian 
Published: February 2019

Background
Adipose tissue plays a central role in obesity-related metabolic diseases such as type 2 diabetes. Salvianolic acid B (Sal B), a water-soluble ingredient derived from Salvia miltiorrhiza, has been shown to reduce obesity and obesity-related metabolic diseases by suppressing adipogenesis. However, the role of Sal B in white adipose tissue (WAT) is not yet clear.

Methods
Illumina Hiseq 4000 was used to study the effects of Sal B on the expression of long non-coding RNA (lncRNA) and circular RNA (circRNA) in epididymal white adipose tissue induced by a high fat diet in obese mice.

Results
RNA-Seq data showed that 234 lncRNAs, 19 circRNAs, and 132 mRNAs were differentially expressed in WAT under Sal B treatment. The up-regulated protein-coding genes in WAT of the Sal B-treated group were involved in the insulin resistance pathway, while the down-regulated genes mainly participated in the IL-17 signaling pathway. Other pathways may play an important role in the formation and differentiation of adipose tissue, such as B cell receptor signaling. Analysis of the lncRNA–mRNA network provides potential targets for lncRNAs in energy metabolism. We speculate that Sal B may serve as a potential therapeutic approach for obesity.
Higher LEAP: Learning Area Coordinators' Leadership Approaches and Faculty Performance in a Philippine University
Authors: Robiños John Robby , Perez Romelia , Jonas Edelina 
Published: February 2019

Leadership is a connection between those who aim to influence and those who choose to be influenced and follow. Leaders at all levels practice definite patterns and systems that guide them to perform at their best. The descriptive-correlational study was conducted to identify the most common leadership approaches of learning area coordinators and determine its association with their faculty performance rating. Seventy - six senior high school faculty members were randomly selected to answer an adopted leadership practices inventory instrument developed by Kouzes and Posner. The survey questionnaire measured the learning area coordinators' level of application of the five leadership approaches. Faculty performance evaluation was also retrieved. Data analysis was carried out using the Chi-square test of correlation. The study findings revealed that learning area coordinators apply the five leadership approaches (modeling the way, inspiring a shared vision, challenging the process, enabling others to act and encouraging the heart) very frequently. Furthermore, about 70% of faculty performed from very satisfactorily to outstanding. Among these leadership approaches, it is modeling the way, challenging the process and encouraging the heart that was associated, X2 (15, 76 = 27.91, 33.66 and 33.11) =24.99, p<.05) to faculty performance evaluation. Based on the findings, recommendations that would enhance and develop leadership styles and practices are given.
Incidence of Restoration Replacement in South-Canara Population - An Epidemiological Survey
Authors: Qaiser Shazeena , Devadiga Darshana , Hegde Mithra N. , Shetty Nireeksha 
Published: February 2019

Aim: Aim of the present study was to determine the incidence of restoration replacement and associated factors among South Canara population.
Place of Study: Department of Conservative Dentistry and Endodontics, AB Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangaluru.
Duration of Study: May 15, 2018-June 15, 2018 (1 month).
Methodology: 2000 patients were examined using mouth mirror and explorer under good lighting facilities, followed by a questionnaire to determine the incidence of restoration replacement and the parameters checked for correlations were type of the restorative material, class of the restoration, reason for the failure, type and position of the tooth, and patient factors such as age-group, gender and oral hygiene measures followed.
Statistical Analysis: Data obtained was statistically analysed by using IBM SBSS version 24.
Differences between variables were analysed by Chi-square test.
Results and Conclusion: Significant differences were found in case of age groups, reason of replacement and the class of restoration The incidence of restoration replacement was 18.2% as 364 patients out of 2000 patients showed the need for replacements. The main cause of the failure was secondary caries followed by material fracture and discoloration. Amalgam was the most commonly replaced restorative material and lower molar teeth showed more failures. It also indicated that replacements were more prevalent in males and for individuals brushing once daily followed by ones with occasional brushing and lastly who brushed twice daily.
Target Serum Urate Achievement and Chronic Kidney Disease Progression in Patients With Gout and Kidney Disease
Authors: Wang Yilun , Dalbeth Nicola , Terkeltaub Robert , Zhang Yuqing , Li Xiaoxiao , Zeng Chao , Lei Guanghua , Wei Jie 
Published: November 2024

ImportanceClinicians often approach urate-lowering therapy (ULT) cautiously in patients with gout and impaired kidney function because they are concerned about the risk of progression to severe or end-stage kidney disease. However, evidence from randomized clinical trials of this association remains inconclusive.ObjectiveTo evaluate the association between achieving target serum urate level with ULT and progression of chronic kidney disease (CKD) to severe or end-stage in patients with gout and impaired kidney function.Design, Setting, and ParticipantsThis was a cohort study using the target trial emulation approach using data from a general practice database (IQVIA Medical Research Database) for 2000 to 2023. Eligible patients were 40 to 89 years old and had gout and CKD stage 3. Data analyses were performed from November 2023 to September 2024.ExposuresLowering serum urate level to target level (&amp;lt;6 mg/dL) using ULT.Main Outcomes and MeasuresSevere or end-stage kidney disease, determined by an estimated glomerular filtration rate of less than 30 mL/min/1.73 m2 on at least 2 occasions more than 90 days apart within 1 year, or at least 1 Read code (per the Refined Etiology, Anatomical Site, and Diagnosis classification) for CKD stages 4 or 5, hemodialysis, peritoneal dialysis, or kidney transplant. The prespecified noninferiority margin of the hazard ratio (HR) was set at 1.2, comparing those who achieved the target serum urate level with those who did not.ResultsAmong the 14 792 participants (mean [SD] age, 73.1 [9.5] years; 9215 men [62.3%] and 5577 women [37.7%]) with gout and with CKD stage 3, the 5-year risk of severe or end-stage kidney disease was 10.32% for those who achieved the target serum urate level and 12.73% for those who did not. Compared with those not achieving the target level, the adjusted 5-year risk difference and HR of severe or end-stage kidney disease for patients achieving the target serum urate level was −2.41% (95% CI, −4.61% to −0.21%) and 0.89 (95% CI, 0.80 to 0.98), respectively.Conclusions and RelevanceThe findings of this cohort study indicate that in patients with gout and CKD stage 3, lowering serum urate level to less than 6 mg/dL vs 6 mg/dL or greater using ULT was not associated with an increased risk of severe or end-stage kidney disease. These findings support optimizing ULT to achieve target serum urate levels when treating patients with gout and impaired kidney function.
Modeling Health and Economic Outcomes of Eliminating Sex Disparities in Youth Physical Activity
Authors: Tamura Kosuke , Martinez Marie F. , Deng Yangyang , Heneghan Jessie , Weatherwax Colleen , Velmurugan Kavya , Chin Kevin L. , Rogers Breanna , Moniruzzaman Mohammad , Whitley Meredith , Bartsch Sarah M. , O’Shea Kelly J. , Dibbs Alexis , Scannell Sheryl , Lee Bruce Y. 
Published: November 2024

ImportanceSex disparities in physical activity (PA) and sports participation among US children and adolescents have been persistent. Quantifying the impact of reducing or eliminating these disparities may help determine how much to prioritize this problem and invest in interventions and policies to reduce them.ObjectiveTo quantify what might happen if existing PA and sports participation disparities were reduced or eliminated between male and female children and adolescents.Design, Setting, and ParticipantsThis simulation study used an agent-based model representing all children (aged 6 to 17 years) in the US, their PA and sports participation levels, and relevant physical and physiologic characteristics (eg, body mass index) as of 2023. Experiments conducted from April 5, 2024, to September 10, 2024, simulated what would happen during the lifetime of each cohort member if PA and sports participation levels for female participants were increased (to varying degrees) to match male participants in the same age group.Main Outcomes and MeasuresHealth outcomes, such as body mass index, incidence of weight-related conditions (eg, stroke, coronary heart disease, type 2 diabetes, and cancer), and economic outcomes (eg, direct medical costs and productivity losses).ResultsThis simulation study modeled 8 299 353 US children and adolescents (4 240 119 [51.1%] male and 4 059 234 [48.9%] female) aged 6 to 17 years. Eliminating PA sex disparities averted 28 061 (95% CI, 25 358-30 763) overweight and obesity cases per cohort by age 18 years, which in turn averted 4869 (95% CI, 4007-5732) weight-related disease cases during their lifetimes and resulted in recurring savings of $333.45 million (95% CI, $290.22 million to $376.68 million) in direct medical costs and $446.42 million (95% CI, $327.39 million to $565.44 million) in productivity losses (in 2024 US dollars) for every new cohort of 6- to 17-year-olds. Reducing PA disparities by 50% averted 9027 (95% CI, 6942-11 112) overweight and obesity cases. Eliminating sex disparities in sports participation averted 41 499 (95% CI, 37 874-45 125) cases of overweight and obesity and 8939 (95% CI, 8088-9790) weight-related disease cases during their lifetimes, generating recurring savings of $713.48 million (95% CI, $668.80 million to $758.16 million) in direct medical costs and $839.68 million (95% CI, $721.18 million to $958.18 million) in productivity losses.Conclusions and RelevanceIn this simulation study of youth PA and sports participation, eliminating sex disparities could save millions of dollars for each new cohort of 6- to 17-year-olds, which could exceed the cost of programs and investments that could enable greater equity.
Measuring Intelligence in 3 Min: Concurrent, Convergent and Discriminant Validity of the Baddeley Reasoning Test
Authors: Furnham Adrian 
Published: November 2024

ABSTRACTThis paper used the author's full data archive to examine the correlates of the Baddeley Reasoning Test (BRT) in six studies with a student population. The correlations between the BRT and Wonderlic Personnel Test (WPT), a 12‐min, well‐established American test of general intelligence, ranged from 0.46 < r < 0.65 in six data sets. Correlations (uncorrected) with a measure of General Knowledge in three studies showed 0.17 < r < 0.36. BRT scores correlated with the Raven's Progressive Matrices r = 0.59. Correlations with a creativity test in four studies was, as predicted, not statistically significant. The usefulness of the BRT is discussed, along with its limitations, particularly criterion‐related validity and range restrictions with attenuation of correlations.
A Highly Sensitive Surface Electrode for Electrophysiological Monitoring
Authors: Lu Jiang , Li Qianming , Huang Qingyun , Li Dan , Jiao Yiding , Wang Yuanzhen , Li Yiran , Zou Kuangyi , Chen Zilin , Gu Jiayi , Zhang Hanting , Wang Jiacheng , Li Fangyan , Yang Shuo , Ye Tingting , Song Jie , He Er , Zhang Ye 
Published: November 2024

AbstractSurface electrodes monitoring various electrophysiological activities with high sensitivity are crucial for studying electrical phenomena in living organisms. However, the sensitivity of current surface electrodes is limited due to electron transmission losses and signal attenuation at the electrode‐skin interface. Here, a bicontinuous liquid metal/polymer film electrode is developed, in which up to 92 wt.% of liquid metal is stably immobilized within a 3D continuous polymer network via electrostatic interactions. This electrode facilitates fast electron transport, enhances skin adhesion through hydrogen bonding, and ensures conformal contact due to its flexibility. As a result, the electrode achieves a sensitivity of 20 µV N−1, representing an improvement of 400% over the highest performance reported to date. This leap in sensitivity enables the high‐resolution monitoring of electrophysiological signals, allowing for earlier and more accurate identification of myocardial infarction abnormalities. Moreover, this high‐sensitivity electrode has the potential to develop an intelligent sensory system for material recognition and provide real‐time warnings in hazardous situations for individuals with tactile impairments.
Iron(III) Triflate‐Assisted Skeletal Rearrangement of Warfarin Framework: A Direct Synthetic Route to a Diverse Series of Biorelevant Flavone‐Coumarin Molecular Hybrids
Authors: Bhowmick Anindita , Brahmachari Goutam 
Published: November 2024

AbstractWe herein disclose a new synthetic strategy for a diverse series of biologically interesting flavone‐coumarin molecular hybrids based on iron(III) triflate‐assisted direct and straightforward skeletal rearrangement of warfarin framework upon heating warfarin analogs in N, N‐dimethylformamide (DMF). Good yields, reasonable reaction time, broad substrate scope and tolerance of various functional groups, scalability, and operational simplicity are the key features of this newly developed method.
Bridging Electrolyte Bulk and Interfacial Chemistry: Dynamic Protective Strategy Enable Ultra‐Long Lifespan Aqueous Zinc Batteries
Authors: Wu Qing , Zhang Jinlong , Yang Song , Luo Fusheng , Yan Zeyu , Liu Xiude , Xie Haibo , Huang Jun , Chen Yiwang 
Published: November 2024

AbstractThe main bottleneck of rechargeable aqueous zinc batteries (AZBs) is their limited cycle lifespans stemming from the unhealthy electrolyte bulk and fragile interface, especially in the absence of dynamic protection mechanism between them. To overcome this limitation, benefitting from their synergistic physical and chemical properties, chitin nanocrystals (ChNCs) are employed as superior colloid electrolyte to bridge electrolyte bulk and interfacial chemistry for ultra‐long lifespan AZBs. This unique strategy not only enables continuous optimization of the electrolyte bulk and interfacial chemistry within the battery but also facilitates self‐repairing of mechanical damage both internally and externally, thereby achieving comprehensive, persistent, and dynamic protection. As a result, the modified zinc (Zn) cells present high Zn plating/stripping coulombic efficiencies of 97.71 % ~99.81 % from 5 to 100 mA cm−2, and remarkably service lifespan up to 8,200 h (more than 11 months). Additionally, the Zn//MnO2 full cell exhibits a high capacity retention of 70.1 % after 3,000 cycles at 5 A g−1. This dynamic protective strategy to challenge aqueous Zn chemistry may open up a new avenue for building better AZBs and beyond.
NADH Analogues Enable Metal‐ and Light‐Free Decarboxylative Functionalization
Authors: Liang Lei , Wang Yue‐Hui , Cui Cheng‐Xing , Deng Xiao‐Shan , Wang Song‐Lin , Guo Hai‐Ming , Li Yingzi , Niu Hong‐Ying , Mao Runze 
Published: November 2024

AbstractHere we report a metal‐ and light‐free decarboxylative functionalization approach enabled by reduced nicotinamide adenine dinucleotide (NADH) analogues. The efficient and operationally simple approach, conducted in 5 minutes from in situ preparation of aryliodine (III) dicarboxylates under open‐air and ambient conditions, enables diverse bond formation and exhibits a broad substrate scope of over 70 examples. Late‐stage functionalization of drug molecules and natural products further demonstrates the synthetic utility of this method. Combined experimental and computational studies elucidate the mechanistic pathway. These transformations streamline the synthesis of sp3 carbon‐enriched compounds, adding a new dimension to classical decarboxylative reactions.
Ligand‐Tuning Metallic Sites in Molecular Complexes for Efficient Water Oxidation
Authors: Gao Yun , Yang Chengdong , Sun Fenglei , He Daping , Wang Xinqiang , Chen Jian , Zheng Xiaobo , Liu Runcong , Pan Hongge , Wang Dingsheng 
Published: November 2024

AbstractMetal‐organic hybrid catalysts with highly tunable single‐sites are promising for oxygen‐evolution reaction (OER), but molecular‐scale understanding of underlying reaction mechanisms still remain elusive on these bulk materials. Herein, we report a direct construction of heterogenized molecular complexes stabilized on carbon substrates via coordinating Fe−Ni sites with four aromatic carboxylate ligands (FeNi‐Lx). The ligands‐tuning π‐π stacking interaction between aromatic carboxylate ligands and carbon supports promote the oxidative charge accumulation on Fe−Ni sites via fast electron transferring, thus the optimized FeNi‐Lx rendering a mass activity of 6680 A gFe/Ni−1 at 0.3 V overpotential. In situ characteristics and theoretical analysis demonstrate that the OH− nucleophilic attack on hypervalent iron sites induce the reconstruction of active Fe−O−Ni species, accompanying with fast valence increasing. Whereas, during OER, the unexpected valence reduction of Fe−O−Ni sites would be attributed to the oxygen‐generating from OOH* intermediates. These findings would establish an essential understanding of the origin of active centers in molecular complexes catalysts for oxygen‐evolution.
Flux Synthesis of Robust Polyimide Covalent Organic Frameworks with High‐Density Redox Sites for Efficient Proton Batteries
Authors: Yang Yi , Wang Sa , Duan Yuqing , Wang Ting , Wang Fengdong , Zhu Haitao , Wang Zhifang , Zhang Kai , Cheng Peng , Zhang Zhenjie 
Published: November 2024

AbstractAqueous proton batteries are attracting increasing attention in the large‐scale next‐generation energy storage field. However, the electrode materials for proton batteries often suffer from low specific capacity and unsatisfactory cycle durability. Herein, we synthesize two highly crystalline and robust polyimide covalent organic frameworks (COFs) through a solvent‐free flux synthesis approach with benzoic acid as a flux and catalyst. The as‐synthesized COFs possess enriched redox‐active sites for proton storage and intrinsic Grotthuss proton conduction, rendering them ideal candidates for proton electrode materials. The optimal COF electrodes achieve a high specific capacity of 180 mAh/g at 0.1 A/g, among the highest COF‐based proton batteries, and exhibit an outstanding rate capability of up to 100 A/g and long‐term cycling stability with capacity retention of 99 % after 5000 cycles at 5 A/g. The assembled full cells deliver a specific capacity of 150 mAh/g at 0.2 A/g with a maximum energy density of 72 Wh/kg and a maximum supercapacitor‐level power density of 64 kW/kg, surpassing all reported COF‐based systems. This work paves a new avenue for the design of electrode materials for aqueous proton batteries with high energy density, power density, rate capability and long‐term cycling stability.
Counterions Determine if Metal‐Organic Cages Convert SO2 to Sulfate or Reversibly Adsorb It
Authors: Percástegui Edmundo G. , Sánchez‐González Elí , de Jesús Valencia‐Loza Sergio , Cruz‐Nava Sofía , Jancik Vojtech , Martínez‐Otero Diego 
Published: November 2024

AbstractThe continuous emission of harmful gases into the atmosphere damages the environment, air quality, and public health worldwide. To mitigate their impact, materials that capture and chemically inactivate gases are required; however, integrating and precisely controlling both abilities within a single material remains challenging. Herein, we demonstrate for the first time that switching between SO2‐physisorption and chemisorption is possible for porous materials by using different counterions, as illustrated with a series of Pd6L8 Metal‐Organic Cages (MOCs). Pd‐MOCs bearing BF4−, PF6−, or SO42− expressed reversible adsorption (up to 3.6 mmol g−1), cyclability, and SO2/CO2 selectivity. NO3− promoted conversion of SO2 to sulfate, as corroborated with M6L8 cages built on Co(II), Cu(II), and Zn(II) ions. Noteworthy, the nitrate derivative of Pd6L8 captures 6.0 mmol g−1 of SO2, cleanly transforms it to SO42− within its cavity in 94 % yield at room temperature, it is quantitatively regenerated, and tolerates humid SO2; such qualities are unprecedented for SO2 adsorbents. The deliberate use of counterions for modulating adsorption could be applied to charged MOFs, COFs, or POCs, potentially leading to the development of new reactivity or catalysis pathways for advanced applications against contaminant gases.
Unraveling the Multifunctional Mechanism of Fluoroethylene Carbonate in Enhancing High‐Performance Room‐Temperature Sodium‐Sulfur Batteries
Authors: Weng Shixiao , Liu Yang , Lu Suwan , Xu Jingjing , Xue Jiangyan , Tu Haifeng , Wang Zhicheng , Liu Lingwang , Gao Yiwen , Sun Guochao , Li Hong , Wu Xiaodong 
Published: November 2024

AbstractRoom‐temperature sodium‐sulfur (RT Na−S) batteries has attracted growing attentions in large‐scale energy storage technology, while the serious shuttle effect and interface side reaction limit its practical application. Despite fluoroethylene carbonate (FEC) has been widely used as an electrolyte additive or co‐solvent to facilitate the optimization of electrode‐electrolyte interphase in RT Na−S batteries, its crucial influence and mechanism have not been clearly understood. Herein, we deeply reveal the two‐steps cathode‐electrolyte interphase (CEI) formation by using FEC as the exclusive electrolyte solvent. The results demonstrate that FEC participates in both rapid nucleophilic reaction and electrochemical decomposition on cathode, which can effectively in situ construct a unique “chocolate‐cookie” shaped CEI consisted of NaF‐rich double layers. This CEI eliminates the shuttle effect and ensures the solid‐solid conversion of sulfur. Along with the stable F‐rich solid‐electrolyte interphase (SEI) formed on the Na anode, the RT Na−S battery delivers an impressive performance (456 mAh g−1 after 1000 cycles at 0.5 C) with almost 100 % Coulombic efficiency. This significantly simplifies electrolyte design and provides valuable insights into the application of FEC in practical Na−S batteries.