bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of rs2910164 polymorphism in MiR-146a gene with psoriasis susceptibility
Authors: Gong Hai-bo , Zhang Shi-lei , Wu Xiu-juan , Pu Xiong-ming , Kang Xiao-jing 
Published: February 2019

Abstract
The rs2910164 single nucleotide polymorphism (SNP) in miR-146a has been implicated in the etiology of psoriasis in different relevant studies with contradictory conclusions and limited sample size. Therefore, the aim of this study was to undertake a systematic review and meta-analysis to estimate the association between rs2910164 SNP and psoriasis. We searched the databases of PubMed, EMBASE, Web of Science, WanFang, and Chinese National Knowledge Infrastructure (CNKI) to identify relevant literatures published before July 15, 2018. Four case–control studies including 2212 cases and 2274 healthy controls from 4 different countries met the predetermined criteria. The effect size was pooled by odds ratios (ORs) and 95% confidence intervals (95%CIs). Recessive model (CC vs CG+GG) was confirmed to be the optimal model. The results indicated that rs2910164 SNP was significantly associated with psoriasis (OR = 0.74, 95%CI 0.60–0.91, P = .004), and individuals with CC-genotype were predisposed to have decreased risk of psoriasis.
The influence of preterm birth on expressive vocabulary at the age of 36 to 41 months
Authors: Brósch-Fohraheim Nina , Fuiko Renate , Marschik Peter B. , Resch Bernhard 
Published: February 2019

Abstract
Children born preterm (PT) have a higher risk of language delays than children born full-term (FT). Expressive vocabulary plays a central role in language development, as later grammar ability can be predicted from earlier vocabulary size.
To determine the effects of preterm birth on expressive vocabulary at the age of 36 to 41 months.
Cross-sectional study of 27 PT (children with a gestational age of ≤ 32 + 0 weeks and/or a birth weight ≤ 1500 g) and 26 FT children (from several kindergartens in Vienna, Austria). The groups were matched regarding age, sex, and monolingual Austrian German speech. They were all examined using the active vocabulary test (AWST-R) and the development test, Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III).
The AWST-R revealed significantly lower scores (46% vs 52%, P
= .027) for PT children. The Bayley-III revealed significantly lower scores in language development (mean 96.3 ± 11.81 vs 105.1 ± 6.24, P
= .002) and the expressive communication subscale (8.78 ± 2.01 vs 10.69 ± 1.49, P
< .001) for PT children, but no differences in cognitive development (98.5 ± 11.08 vs 100.8 ± 6.43, P = .369) or on the receptive communication subscale (10.15 ± 2.23 vs 11.08 ± 1.09, P = .060).
Preterm children tested had less expressive vocabulary (AWST-R and Bayley-III) than those born full-term, while test results in their cognitive development and receptive communication (Bayley-III) did not differ.
An inadvertent subarachnoid injection reversed by cerebrospinal fluid lavage for the treatment of chronic low back pain
Authors: Sun Xiaodi , Liu Shijiang , Liu Cunming , Xu Jijun , Sun Jie , Pan Yinbing 
Published: February 2019

Abstract

Rationale:
We present a case of high spinal anesthesia after inadvertent injection of local anesthetics and corticosteroids into the subarachnoid space during attempted epidural injection. Cerebrospinal fluid (CSF) lavage is a suitable method for treatment.

Patient concerns:
A 45-year-old woman presented with posterior thigh, leg, and ankle pain for >6 months and was treated with epidural injection. Five minutes after the third time of epidural injection, the patient complained loss of sensation and muscle strength in the lower extremities and abdominal area.

Diagnoses:
A high spinal anesthesia was confirmed by the patient loss of sensation and muscle strength in the lower extremities and abdominal area.

Interventions:
CSF lavage was performed for treatment.

Outcomes:
After CSF lavage, the patient gradually returns to normal sensory and motor functions of lower limbs. On the fourth day, the patient sensed her physical function restoring gradually and was discharged uneventfully. At 4-month follow-up, the patient could have normal activities without obvious subsequent complications and any pain.

Lessons:
We conclude that CSF lavage could be a helpful maneuver to clear lidocaine and betamethasone and avoid potential nerve damage caused by an unintentional intrathecal injection during an epidural injection for the treatment of chronic low back pain.
PICC insertion in the sitting position for a patient with congestive heart failure
Authors: Mitsuda Shingo , Tokumine Joho , Matsuda Rena , Yorozu Tomoko , Asao Takayuki 
Published: February 2019

Abstract

Rationale:
A peripherally inserted central catheter (PICC) is typically inserted with the patient in the supine position. Here, we placed a PICC in a patient in the sitting position, in order to treat congestive heart failure.

Patient concerns:
A 65-year-old man was diagnosed with end-stage lung cancer. He had experienced septic shock and was medicated with continuous infusion of noradrenaline through a peripheral vein, in order to maintain sufficient blood pressure. However, indwelling peripheral venous catheters were difficult to place and maintain.

Diagnosis:
The patient experienced orthopnea due to congestive heart failure and could not assume any other position.

Interventions:
An anesthesiologist performed PICC placement while the patient was in the sitting position, using ultrasound guidance.

Outcomes:
The patient's orthopnea was slightly ameliorated, and he was able to sleep at night.

Lessons:
The technique of inserting a PICC in the sitting position is simple and feasible. This approach may be useful for patients in whom central venous access is needed, but the supine position cannot be achieved.
The efficacy of the traditional Chinese medicine Jia Wei Niu Bang Zi granule combined with methotrexate in treating active rheumatoid arthritis
Authors: Wang Yi-Ru , Liu Li , Wang Xiao-Yun , Wang Qiong , Yao Min , Cui Xue-jun , Mao Jian-Chun , Liu Jian , Gu Xiao-Hua , Chen Yong-Li , Yu Xiang , Shi Qi , Liang Qian-Qian , Wang Yong-Jun 
Published: February 2019

Abstract

Background:
Rheumatoid arthritis (RA) is a chronic systemic and autoimmune inflammatory disease ending with the destruction of joints. Current therapies can relieve RA symptoms, but some also bring severe adverse events. Therefore, an effective and safe therapeutic strategy remains to be created to benefit patients with RA by large. Jia Wei Niu Bang Zi granule (NBZG) consisting of RA-fighting Chinese herbals has been used in Longhua Hospital in the last several decades. NBZG has potential therapeutic effect on RA, which should be evaluated by larger sample clinical trial.

Methods:
A multicenter, randomized, double-blind, placebo-controlled clinical trials will be conducted to determine the efficiency of NBZG in pain relief and joint protection. A total of 120 patients with active RA will be enrolled, and treated with NBZG or placebo for 12 weeks. The primary outcome measurements include rate of American College of Rheumatology (ACR) 50 at 12 weeks’ treatment. The 2nd outcome measurements include rate change of ACR20, ACR70, the disease activity score (DAS) 28, 36-item Short-Form Health Survey Questionnaire, Health Assessment Questionnaire - Disability Index, score changes of Patient Assessment of Arthritis Pain, Patient Global Assessment of Arthritis, and the Athens insomnia scale at the same time points.

Discussion:
Although NBZG has shown efficacy in treating RA in Longhua Hospital for decades, the universality of this efficacy needs evaluated. The results of this trial will provide a convincing evidence about NBZG's efficacy in treating active RA in a large population.

Trial registration:
ClinicalTrials.gov ID: NCT03173040 (registered on May 30, 2017)
Clinical utility of miniprobe endoscopic ultrasonography for prediction of invasion depth of early gastric cancer
Authors: Luo Mingchi , Li Lifeng 
Published: February 2019

Abstract

Background:
Recently, some studies assessed the clinical utility of miniprobe endoscopic ultrasonography for prediction of invasion depth of early gastric cancer (GC). However, the results remain inconsistent.

Objectives:
We conducted a meta-analysis to assess the clinical utility of miniprobe endoscopic ultrasonography for diagnostic of invasion depth of early GC.

Methods:
We systematically searched several online electronic databases including PubMed, China National Knowledge Infrastructure, Web of Science, Embase, and Wanfang from initial library to July 20, 2018, identifying the study about miniprobe endoscopic ultrasonography for diagnostic of invasion depth of early GC. Bivariate mixed effects models were used to calculate the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) with theirs 95% confidence intervals (CIs).

Results:
Nineteen studies with 3401 patients were included in the meta-analysis. The bivariate mixed effect model indicated that the overall diagnostic sensitivity was 0.86 (95%CI: 0.79–0.91) and the specificity was 0.73 (95%CI: 0.66–0.78). The area under the curve was 0.84 (95%CI: 0.81–0.87). We also estimated the other pooled parameters as follows: the pooled PLR was 3.13 (95%CI: 2.55–3.84), the pooled NLR was 0.19 (95%CI: 0.13–0.28), the diagnostic score was 2.78 (95%CI: 2.33–3.23), and the diagnostic odds ratio was 16.1 (95%CI: 10.23–25.36). Subgroup analysis indicated that ethnicity may be the decisive factor on heterogeneity.

Conclusions:
The present study indicated that the miniprobe endoscopic ultrasonography had a moderate diagnostic ability for invasion depth of early GC. The diagnostic utility was influenced by ethnicity. Further research is required to confirm the present findings and explore the potential factors of heterogeneity.
Current Status of helicopter emergency medical services in China
Authors: Xu Ding , Luo Peng , Li Sheng , Pfeifer Roman , Hildebrand Frank , Pape Hans-Christoph 
Published: February 2019

Abstract

Background:
After nearly 20 years of development, China has realized some achievements in helicopter emergency medical services (HEMS). The purpose of this article is to introduce and evaluate the development and characteristics of HEMS in China by collecting and analyzing relevant literature and, in so doing, help this vital service to further develop.

Method:
We conducted a Pubmed, Medline, Embase, ScienceDirect, Wanfang, CNKI, and VIP search of the literature on HEMS of China published between January 1950 and April 2017. The title, author name, number of authors, publishing date, country or region of origin, institution, type of article, study topic, funding source, and level of evidence of each article were recorded and analyzed.

Results:
There were 41 papers included in the analysis. All articles were published in Chinese. The selected articles were published between 2002 and 2017. The 41 articles originated from China, but 7 different regions were represented: East China (n = 14), followed by North China (n = 12), Central China (n = 8), Southwest China (n = 3), South China (n = 2), and Northwest China (n = 2). The articles included 18 clinical studies, 12 reviews, and 11 clinical guidelines. Among these, 22 articles were from public hospitals; 18 were from military units and 1 came from a private hospital. One article from the public hospitals was funded by public foundations (4.5%); 11 articles from the army units received support from Army funding (61.1%). Compared with the public and private hospitals, articles from military units were more likely to receive financial support (χ2 = 15.7 P <.01). All the articles were assigned a level of evidence from 1 to 5. Level 5 (78.0%) was the most frequent level of evidence. There were 7 studies at level 4. Only 2 articles were assigned to level 3. There were no articles at levels 1 or 2.

Conclusions:
China's HEMS is a relatively new service. Its level of development is low, interregional development is uneven, and cooperation has been insufficient. We need to strengthen capital investment and develop a unified guideline to further enhance the development of HEMS in China.
Comparison of the effectiveness of different umbilical cord care in infants
Authors: Shang Yi , Sun Yue 
Published: February 2019

Abstract

Background:
More and more studies were performed to explore the effectiveness of umbilical cord care practices. However, the results remain controversial. Hence, the aim of the review was to evaluate and compare the effectiveness of different umbilical cord care in infants through network meta-analysis.

Methods:
A systematic literature search for relevant articles published in the English language will be conducted in PubMed, EMBASE, the Cochrane library, and Chinese Biomedical Literature Database from their inception to December 2018. Randomized controlled trials (RCTs) that compared the effectiveness of different types of umbilical cord care practices will be included. Cord infection, illness, and death will be used to assess the clinical effect. Risk of bias assessment of the included RCTs will be conducted by the Cochrane risk of bias tool. The WinBUGS 1.4.3 software will be used to perform the network meta-analysis and the result figures will be generated by STATA V.15.0 software. Grading of recommendations assessment, development, and evaluation will be used to assess the quality of evidence.

Results:
The results will be published in a peer-reviewed journal.

Conclusion:
This will be the first network meta-analysis to evaluate and compare the effectiveness of different umbilical cord care in infants. Our study will generate evidence of cord care for infants and provide suggestions for clinical practice or guideline.

PROSPERO registration number:
CRD42018118052.
Somatosensory stimulation treatments for postoperative analgesia of mixed hemorrhoids
Authors: Zhang An-Mei , Chen Min , Tang Tai-Chun , Qin Di , Yue Ling , Zheng Hui 
Published: February 2019

Abstract

Background:
Pain after hemorrhoidal surgery bothers both clinicians and patients. Somatosensory stimulation treatments have shown promising effect on the pain after hemorrhoidal surgery, but the comparative effectiveness between them has not been studied. We aim to determine the relative effectiveness among these treatments on pain relief after hemorrhoidal surgery by using network meta-analysis.

Method:
We will search the following electronic databases: MEDLINE, EMBASE, the Cochrane library, Chinese Biomedicine database (CBM), China National Knowledge Infrastructure (CNKI). We will include randomized controlled trials (RCTs) that examine the effect of somatosensory stimulation treatments on pain after hemorrhoidal surgery. The primary outcome will be the responder rate after treatment. The secondary outcomes will include the assessments with pain intensity scales (visual analog scale, numeric rating scale, or other scales) on day 1 to 7 after surgery. Two independent reviewers will extract needed information from eligible trials using standardized electronic forms. Network meta-analysis will be performed using a frequentist framework based on electrical network theory. The relative effectiveness of the treatments will be ranked by using P score, which is the mean probability of a treatment ranking the best in all treatments. Meta-regression will be performed to assess the impact of surgery type, anesthesia methods, and funding source on the treatment ranking. The quality of the eligible RCTs will be evaluated by the Cochrane risk of bias tool.

Ethics and dissemination:
The result of this network meta-analysis will clarify which is the relatively best somatosensory-stimulation treatment in relieving postoperative pain caused by hemorrhoidal surgery, and the review will, therefore, guide the management of postoperative pain after hemorrhoidal surgery for clinicians and patients. This review does not require ethical approval and will be reported in a peer-reviewed journal.

Trial registration number:
PROSPERO CRD42018115558.
Review: Acute superior mesenteric artery embolism
Authors: Liao Guanyi , Chen Siyang , Cao Haoyang , Wang Wuwan , Gao Qing 
Published: February 2019

Abstract

Background:
Acute mesenteric ischemia (AMI) is a life-threatening medical condition that occurs when a sudden decreased perfusion to the intestines which leads to bowel infarction, and acute superior mesenteric artery embolism (ASMAE) is the main cause of AMI. Unfortunately, with the improvement of diagnosis and treatment technology, the mortality remains high due to less frequent clinical suspicion resulted from the unclear clinical manifestation and non-specific laboratory findings.

Methods:
Relevant studies published were identified by searching the PubMed, Embase and Cochrane Library databases. This review presented the literatures to introduce the research progress of ASMAE in recent years.

Results:
Patients with the history of atrial fibrillation, heart valve disease and atherosclerosis should be considered as ASMAE. Laboratory findings are insensitive and unspecific, however, angiography and Computed tomography angiography (CTA) can provide a clear diagnosis sensitively and specifically. Endovascular approaches have been increasingly reported in multiple case series. The key to successful treatment of AMI involves early clinical recognition and early intervention to move the embolus, which can reduce the rate of misdiagnosis and save the precious time and lives of patients.

Conclusions:
Loss of time eventually leads to progression of ischemia to transmural bowel necrosis with peritonitis and septicemia, which may further worsen patients’ outcomes. It is important for physicians to make a timely and accurate diagnosis, which can save precious time and reduce the mortality.
Long-term adjuvant imatinib treatment for a patient who underwent complete resection of a localized recurrent gastrointestinal stromal tumor after preoperative imatinib treatment
Authors: Tjhoi Welda E.H. , Li Kai , Shou Chun-hui , Yang Wei-li , Yu Ji-ren 
Published: February 2019

Abstract

Rationale:
The efficiency and tolerance of long-term adjuvant imatinib treatment for patient who underwent complete resection of a localized recurrent gastrointestinal stromal tumor (GIST) was unknown.

Patient concerns:
A 45-year-old man underwent complete resection of an intestinal GIST in August 2001. Four years later, a giant (11 × 8 × 6 cm) recurrent GIST located in the retroperitoneum was detected.

Diagnosis:
The recurrent tumor was positive for CD117 by immunohistochemistry.

Interventions:
The recurrent tumor was completely resected after 4 months of effective imatinib treatment (400 mg/day), and the patient continued imatinib treatment postoperatively. In June 2011, imatinib treatment was stopped for 3 weeks because of hepatitis B infection, and resumed with a reduced dose level of 300 mg/day when liver function recovered. In March 2017, imatinib treatment was interrupted again for 12 days because the patient underwent cholecystectomy.

Outcomes:
In December 2017, a computed tomography scan showed no signs of tumor recurrence. To date, the patient has been under adjuvant imatinib treatment for >12 years without severe side effects. The plasma concentration of imatinib (detected in February 2018) was trough concentration (Cmin) 1015.7 ng/mL and peak concentration (Cmax) 1550.5 ng/mL.

Lessons:
This case report highlights the active role of long-term (>12 years) imatinib treatment after complete resection of localized recurrent GIST.
Combination of S100B and procalcitonin improves prognostic performance compared to either alone in patients with cardiac arrest
Authors: Jang Jae Ho , Park Won Bin , Lim Yong Su , Choi Jea Yeon , Cho Jin Seong , Woo Jae-Hyug , Choi Woo Sung , Yang Hyuk Jun , Hyun Sung Youl 
Published: February 2019

Abstract
This study aimed to determine whether the combination of procalcitonin (PCT) and S100B improves prognostic performance compared to either alone in cardiac arrest (CA) patients treated with targeted temperature management (TTM).
We performed a prospective cohort study of CA patients treated with TTM. PCT and S100B levels were obtained at 0, 24, 48, and 72 hours after return of spontaneous circulation. The prognostic performance was analyzed using each marker and the combination of the 2 markers for predicting poor neurological outcome at 3 months and mortality at 14 days and 3 months.
A total of 97 patients were enrolled, of which 67 (69.1%) had poor neurological outcome. S100B showed a better prognostic performance (area under the curve [AUC], 0.934; sensitivity, 77.6%; and specificity, 100%) than PCT (AUC, 0.861; sensitivity, 70.2%; and specificity, 83.3%) with the highest prognostic value at 24 hours. The combination of 24-hour PCT and S100B values (S100B ≥0.2 μg/L or PCT ≥6.6 ng/mL) improved sensitivity (85.07%) compared with S100B alone. In multivariate analysis, PCT was associated with mortality at 14 days (odds ratio [OR]: 1.064, 95% confidence interval [CI]: 1.014–1.118), whereas S100B was associated with neurological outcomes at 3 months (OR: 9.849, 95% CI: 2.089–46.431).
The combination of PCT and S100B improved prognostic performance compared to the use of either biomarker alone in CA patient treated with TTM. Further studies that will identify the optimal cutoff values for these biomarkers must be conducted.
Effect of Gabapentin on Sexual Function in Vulvodynia: A Randomized, Placebo-controlled Trial
Authors: Bachmann Gloria A. , Brown Candace S. , Phillips Nancy A. , Rawlinson Leslie A. , Yu Xinhua , Wood Ronald , Foster David C. 
Published: February 2019

(Abstracted from Am J Obstet Gynecol 2019;220:89.e1–89.e8)
Vulvodynia is a chronic pain syndrome characterized by symptoms such as stinging, burning, irritation, or itching of the vulva. Women with vulvodynia experience deficits across all aspects of sexual function.
Surgery Is Not Superior to Dilation for the Management of Vaginal Agenesis in Mayer-Rokitansky-Küster-Hauser Syndrome: A Multicenter Comparative Observational Study in 131 Patients
Authors: Cheikhelard Alaa , Bidet Maud , Baptiste Amandine , Viaud Magali , Fagot Christine , Khen-Dunlop Naziha , Louis-Sylvestre Christine , Sarnacki Sabine , Touraine Philippe , Elie Caroline , Aigrain Yves , Polak Michel 
Published: February 2019

(Abstracted from Am J Obstet Gynecol 2018;219:281.e1–281.e9)
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare congenital condition characterized by vaginal agenesis, which impairs sexuality and has a negative impact on quality of life (QOL). Classic management of this condition is to create a cavity allowing satisfying painless penetrative intercourse.