bluuebunny/crossref_metadata_2025_split huggingface dataset:
<b>A taxonomic study on trachypenaeid prawns with special reference to Indian records</b>
Authors: Chanda Angsuman 
Published: February 2018

Burkenroad created two subgenera of the genus Trachypenaeus viz., Trachypenaeus (Trachypenaeus) and Trachypenaeus (Trachysalambria) in 1934. These two subgenera were raised to the status of genus by Pérez Farfante and Kensley and simultaneously created two new genera for the group namely Megokris and Rimapenaeus. As such the trachypenaeid group of penaeid prawns consists of four valid genera namely Trachypenaeus, Trachysalambria, Megokris and Rimapenaeus. During the present study genus Megokris is being synonymised under its original genus Trachypenaeus. Therefore, the main objective of the present study is to propose a revision to the trachypenaeid group of penaeid prawn and to prepare a comprehensive document for the group recorded from Indian water. The study area represents genus Trachysalambria and Megokris with three species under each genus.
<b>Non-Inverse J - shaped population distribution: Peculiarity of Red Sanders forests</b>
Authors: Ramanan S. Suresh , Kunhamu T. K. 
Published: February 2018

Response to the published article "A study on the density, population structure and regeneration of Red Sanders (Pterocarpus santalinus) (Fabales: Fabaceae) in a protected natural habitat of Sri Lankamalleswara Wildlife Sanctuary, Andhra Pradesh, India" by Ankalaiah et al. 2017.
Circulating Concentrations of Redox Biomarkers Do Not Improve the Prediction of Adverse Cardiovascular Events in Patients With Type 2 Diabetes Mellitus
Authors: Cournot Maxime , Burillo Elena , Saulnier Pierre‐Jean , Planesse Cynthia , Gand Elise , Rehman Michaela , Ragot Stéphanie , Rondeau Philippe , Catan Aurélie , Gonthier Marie‐Paule , Feigerlova Eva , Meilhac Olivier , Hadjadj Samy 
Published: February 2018

Background
Despite pathophysiological relevance and promising experimental data, the usefulness of biomarkers of oxidative stress for cardiac risk prediction is unclear. The aim of our study was to investigate the prognostic value of 6 biomarkers exploring different pathways of oxidative stress for predicting adverse cardiovascular outcomes in patients with type 2 diabetes mellitus beyond established risk factors.

Methods and Results

The
SURDIAGENE
(Survie, Diabete de type 2 et Genetique) prospective cohort study consecutively recruited 1468 patients with type 2 diabetes mellitus. Assays were performed at baseline, and incident cases of major adverse cardiovascular events (
MACE
)—first occurrence of cardiovascular death, nonfatal myocardial infarction, or stroke—were recorded during a median of 64 months. Advanced oxidation protein products, oxidative hemolysis inhibition assay, ischemia‐modified albumin, and total reductive capacity of plasma were not associated with the risk of
MACE
in univariate analyses. Fluorescent advanced glycation end products and carbonyls were associated with
MACE
(hazard ratio=1.38 per
SD
, 95% confidence interval 1.24‐1.54,
P
<0.001 and hazard ratio=1.15 per
SD
, 95% confidence interval 1.04‐1.27,
P
=0.006, respectively) in univariate analysis, but when added to a multivariate predictive model including traditional risk factors for
MACE
, these markers did not significantly improve c‐statistics or integrated discrimination index of the model.

Conclusions

These plasma concentrations of 6 markers, which cover a broad spectrum of oxidative processes, were not significantly associated with
MACE
occurrence and were not able to improve
MACE
risk discrimination and classification beyond classical risk factors in type 2 diabetes mellitus patients.
Kidney Mass Reduction Leads to
l
‐Arginine Metabolism‐Dependent Blood Pressure Increase in Mice
Authors: Pillai Samyuktha Muralidharan , Seebeck Petra , Fingerhut Ralph , Huang Ji , Ming Xiu‐Fen , Yang Zhihong , Verrey François 
Published: February 2018

Background

Uninephrectomy (UNX) is performed for various reasons, including kidney cancer or donation. Kidneys being the main site of
l
‐arginine production in the body, we tested whether UNX mediated kidney mass reduction impacts
l
‐arginine metabolism and thereby nitric oxide production and blood pressure regulation in mice.

Methods and Results

In a first series of experiments, we observed a significant increase in arterial blood pressure 8 days post‐UNX in female and not in male mice. Further experimental series were performed in female mice, and the blood pressure increase was confirmed by telemetry.
l
‐citrulline, that is used in the kidney to produce
l
‐arginine, was elevated post‐UNX as was also asymmetric dimethylarginine, an inhibitor of nitric oxide synthase that competes with
l
‐arginine and is a marker for renal failure. Interestingly, the UNX‐induced blood pressure increase was prevented by supplementation of the diet with 5% of the
l
‐arginine precursor,
l
‐citrulline. Because
l
‐arginine is metabolized in the kidney and other peripheral tissues by arginase‐2, we tested whether the lack of this metabolic pathway also compensates for decreased
l
‐arginine production in the kidney and/or for local nitric oxide synthase inhibition and consecutive blood pressure increase. Indeed, upon uninephrectomy, arginase‐2 knockout mice (Arg‐2
−/−
) neither displayed an increase in asymmetric dimethylarginine and
l
‐citrulline plasma levels nor a significant increase in blood pressure.

Conclusions

UNX leads to a small increase in blood pressure that is prevented by
l
‐citrulline supplementation or arginase deficiency, 2 measures that appear to compensate for the impact of kidney mass reduction on
l
‐arginine metabolism.
Network of MicroRNAs Mediate Translational Repression of Bone Morphogenetic Protein Receptor‐2: Involvement in HIV‐Associated Pulmonary Vascular Remodeling
Authors: Chinnappan Mahendran , Mohan Aradhana , Agarwal Stuti , Dalvi Pranjali , Dhillon Navneet K. 
Published: February 2018

Background

Earlier, we reported that the simultaneous exposure of pulmonary arterial smooth muscle cells to
HIV
proteins and cocaine results in the attenuation of antiproliferative bone morphogenetic protein receptor‐2 (
BMPR
2) protein expression without any decrease in its
mRNA
levels. Therefore, in this study, we aimed to investigate the micro
RNA
‐mediated posttranscriptional regulation of
BMPR
2 expression.

Methods and Results

We identified a network of
BMPR
2 targeting micro
RNA
s including miR‐216a to be upregulated in response to cocaine and Tat‐mediated augmentation of oxidative stress and transforming growth factor‐β signaling in human pulmonary arterial smooth muscle cells. By using a loss or gain of function studies, we observed that these upregulated micro
RNA
s are involved in the Tat‐ and cocaine‐mediated smooth muscle hyperplasia via regulation of
BMPR
2 protein expression. These in vitro findings were further corroborated using rat pulmonary arterial smooth muscle cells isolated from
HIV
transgenic rats exposed to cocaine. More importantly, luciferase reporter and in vitro translation assays demonstrated that direct binding of novel miR‐216a and miR‐301a to 3′
UTR
of
BMPR
2 results in the translational repression of
BMPR
2 without any degradation of its
mRNA
.

Conclusions

We identified for the first time miR‐216a as a negative modulator of
BMPR
2 translation and observed it to be involved in
HIV
protein(s) and cocaine‐mediated enhanced proliferation of pulmonary smooth muscle cells.
Validation of the name Pleurothallis marioi (Zambrano et al. in Phytotaxa 308: 81)
Authors: ZAMBRANO ROMERO BOSCO JAVIER , SOLANO RODOLFO , WILSON MARK 
Published: February 2018

Pleurothallis marioi was described in Phytotaxa as a new species on 2 June 2017 (Zambrano et al. 2017: 81). However, this name was invalid according to Article 40 of the International Code of Botanical Nomenclature (McNeill et al. 2012), because the protologue was ambiguous in specifying the holotype; whether it was the material in spirit, or a cultivated material that would be unsuitable as a holotype according to Article 40 of the ICN (McNeill et al. 2012). Since all other requirements of the Melbourne Code have been fulfilled, here we provide a new, unambiguous holotype assignment in order to validate this species name P. marioi Zambrano et al. (2017: 81).
A bittersweet relationship: What does it mean to be the caregiver of a patient with bipolar disorder?
Authors: Vargas-Huicochea Ingrid , Berenzon Shoshana , Rascón María Luisa , Ramos Luciana 
Published: February 2018

Background: As with most of the chronic illnesses, the changes and consequences brought on by bipolar disorder (BD) are not exclusive to the patient and often spread to those around them, especially for direct caregivers of these patients. It is known that there is a significant emotional and physical toll among persons who coexist daily with those who suffer from this disorder. Objective: Aware of the importance of the role played by informal caregivers (especially the family) in the stability and evolution of patients with bipolar disorder, this study seeks to explore the perception that family members responsible for bipolar persons have of themselves as caregivers of these patients. Method: This is a qualitative study using a phenomenological design, for which the technique of focused or semi-structured interviews was employed. Ten caregivers of people with diagnosis of BD agreed to participate. Results: Within the family, it is a single individual who has the role of caregiver. Experiences and meanings that are generated into the nucleus of the patient–caregiver relationship are full of ambivalence and involve many aspects worthy of analysing, such as the development of identities, the feminization of patient care, the process of therapeutic decision-making and the evolution of the disease. Conclusions: It is necessary to integrate evaluation and attention for patients’ caregivers, recognizing them as individuals and elucidating their constructed meanings and the dynamics established in their relationship with patients. In this way, there would be a more integrative clinical approach of the patient–caregiver relationship, considering not only the necessary pharmacological treatments but also accompanying both patient and family, along the path they travel as they experience BD.
Dispensing Naloxone Without a Prescription: Survey Evaluation of Ohio Pharmacists
Authors: Thompson Erin L. , Rao P. S. S. , Hayes Christopher , Purtill Catherine 
Published: February 2018

Background: The Centers for Disease Control and Prevention (CDC) reports a 200% escalation in the rate of opioid overdose deaths in the United States. Unfortunately, Ohio has been deemed the epicenter of the nation’s opioid epidemic. In 2015, Ohio passed a bill that permits a pharmacist to distribute naloxone without a prescription. Objectives: This survey was aimed to discover pharmacists’ knowledge of naloxone and Ohio law, perceived barriers that may prohibit naloxone dispensing, and Ohio pharmacists’ general confidence, comfort, perception, and experience dispensing naloxone per physician protocol. Methods: Pharmacists’ knowledge of naloxone and Ohio law pertaining to dispensing naloxone; perceived barriers to naloxone distribution; and overall experience, willingness, comfort, and perceptions of personally supplying naloxone were assessed using multiple-choice and Likert-type scale questions through an e-mail survey. Results: Overall, Ohio pharmacists were knowledgeable about naloxone and displayed confidence in their training and ability to provide patient education on naloxone. Pharmacists were less certain about Ohio law pertaining to naloxone distribution, especially those who have been in practice longer. Pharmacists indicated several barriers to dispensing naloxone and the need for more training. Younger pharmacists were more likely to report a concern with clientele who would frequent their pharmacy and moral and ethical concerns as barriers to dispensing naloxone. Conclusion: Additional educational programs should be delivered to Ohio pharmacists to inform them of the state law and policies. Continuing education programs that review substance abuse and attempt to reduce social stigma may assist with increasing naloxone distribution to those in need, especially, if directed toward younger pharmacists in Ohio.
Staff awareness of the application of Mental Health and Guardianship Legislation in the care of hospitalised older persons
Authors: Panesar Narinder , Valachova Iveta , Schmidtman Robert , Chan Daniel Kam Yin 
Published: February 2018

Objective: The study aimed to survey hospital staff knowledge of the application of the Mental Health Act 2007 (NSW) (MHA) and the Guardianship Act 1987 (NSW) (GA) in the care and treatment of older persons in a teaching hospital in Sydney. Method Over a two-month period in 2017, a survey questionnaire was distributed to staff involved in older persons’ care across the hospital. Results: The majority of the hospital staff demonstrated basic theoretical knowledge of both the GA (76%) and of the MHA (84.5%). Fewer (64.5%) appeared to understand the practical application of the MHA in the hypothetical clinical situations. An even lower proportion of staff appeared to understand the application of the GA either to obtain consent for medical treatment or to appoint a guardian through the Guardianship Division of the NSW Civil and Administrative Tribunal (NCAT). Conclusion: Although clinical staff of the hospital displayed fair knowledge and awareness about the application of the MHA and the GA to inpatient care of older adults, further education is necessary, particularly about the application of the GA. The authors suggest similar findings may occur at other New South Wales hospitals, which may raise concern and need for education.
In Search of a Gold Standard Patient-Reported Outcome Measure for Use in Chemotherapy- Induced Peripheral Neuropathy Clinical Trials
Authors: Smith Ellen M. Lavoie , Knoerl Robert , Yang James J. , Kanzawa-Lee Grace , Lee Deborah , Bridges Celia M. 
Published: February 2018

Purpose: To test a reduced version—CIPN15—of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Chemotherapy-Induced Peripheral Neuropathy scale (QLQ-CIPN20) to establish a possible gold-standard patient-reported outcome measure for chemotherapy-induced peripheral neuropathy (CIPN). Methods: Using a prospective, longitudinal, case–control design, patients (n = 121) receiving neurotoxic chemotherapy completed the CIPN15 at baseline and 12 weeks and underwent objective neurological assessment using the 5-item Total Neuropathy Score-Clinical (TNSc). Healthy controls (n = 30) completed the CIPN15 once. Structural validity was evaluated using factor analysis. Because a stable factor structure was not found, a sum score was used to evaluate measures of the CIPN15’s psychometric properties—reliability, validity, sensitivity, and responsiveness—as follows: internal consistency via Cronbach’s α and item–item correlations; test–retest reliability via correlation between 2 CIPN15 scores from each patient; concurrent validity via correlation between CIPN15 and 5-item TNSc scores; contrasting group validity via comparison of CIPN15 scores from patients and healthy controls; sensitivity via descriptive statistics (means, standard deviation, ranges); and responsiveness via Cohen’s d effect size. Results: Most patients received single agent oxaliplatin (33.7%), paclitaxel (21.2%), or more than 1 neurotoxic drug concurrently (29.8%). Factor analysis revealed no stable factor structure. Cronbach’s α for the CIPN15 sum score was 0.91 (confidence interval [CI] = 0.89-0.93). Test–retest reliability was demonstrated based on strong correlations between the 2 scores obtained at the 12-week time point ( r = 0.86; CI = 0.80-0.90). The CIPN15 and 5-item TNSc items reflecting symptoms (not signs) were moderately correlated ( r range 0.57-0.72): concurrent validity. Statistically significant differences were found between patient and healthy control CIPN15 mean scores ( P < .0001): contrasting group validity. All items encompassed the full score range but the CIPN15 linearly converted sum score did not: sensitivity. The CIPN15 was responsive based on a Cohen’s d of 0.52 (CI = 0.25-0.79). Conclusion: The sum-scored CIPN15 is reliable, valid, sensitive, and responsive when used to assess taxane- and platinum-induced CIPN.
Mesenchymal stem cell therapy in cats: Current knowledge and future potential
Authors: Quimby Jessica M , Borjesson Dori L 
Published: February 2018

Practical relevance: Stem cell therapy is an innovative field of scientific investigation with tremendous potential for clinical application in veterinary medicine. Based on the known desirable immunomodulatory properties of mesenchymal stem cells, this therapy holds promise for the treatment of a variety of inflammatory diseases in cats. Aims: This review details our current understanding of feline stem cell biology and proposed mechanism of action. Studies performed in feline clinical trials for diseases including gingivostomatitis, chronic enteropathy, asthma and kidney disease are summarized, with the goal of providing an overview of the current status of this treatment modality and its potential for the future.
Haemoplasmosis in cats: European guidelines from the ABCD on prevention and management
Authors: Tasker Séverine , Hofmann-Lehmann Regina , Belák Sándor , Frymus Tadeusz , Addie Diane D , Pennisi Maria Grazia , Boucraut-Baralon Corine , Egberink Herman , Hartmann Katrin , Hosie Margaret J , Lloret Albert , Marsilio Fulvio , Radford Alan D , Thiry Etienne , Truyen Uwe , Möstl Karin 
Published: February 2018

Overview: Haemoplasmas are haemotropic bacteria that can induce anaemia in a wide range of mammalian species. Infection in cats: Mycoplasma haemofelis is the most pathogenic of the three main feline haemoplasma species known to infect cats. ‘ Candidatus Mycoplasma haemominutum’ and ‘ Candidatus Mycoplasma turicensis’ are less pathogenic but can result in disease in immunocompromised cats. Male, non-pedigree cats with outdoor access are more likely to be haemoplasma infected, and ‘ Candidatus M haemominutum’ is more common in older cats. All three haemoplasma species can be carried asymptomatically. Transmission: The natural mode of transmission of haemoplasma infection is not known, but aggressive interactions and vectors are possibilities. Transmission by blood transfusion can occur and all blood donors should be screened for haemoplasma infection. Diagnosis and treatment: PCR assays are the preferred diagnostic method for haemoplasma infections. Treatment with doxycycline for 2–4 weeks is usually effective for M haemofelis-associated clinical disease (but this may not clear infection). Little information is currently available on the antibiotic responsiveness of ‘ Candidatus M haemominutum’ and ‘ Candidatus M turicensis’.
Crystalline lens endocapsular fragmentation using an elastic loop filament
Authors: Diakonis Vasilios F , Cook Brittany N , Desai Neel R , Weinstock Alexander J , Weinstock Robert J 
Published: February 2018

Purpose: To describe a novel mechanical endocapsular fragmentation technique of the crystalline lens during cataract surgery using a loop elastic-thin filament. Methods: An alternative method to mechanically fragment the crystalline lens utilizing a nitinol loop is described. This device achieves lens sectioning in multiple pieces, decreasing ultrasonic energy expenditure during cataract surgery. Results: Endocapsular fragmentation of crystalline lens was achieved using a nitinol loop filament, without the use of ultrasound energy. Conclusion: This surgical technique demonstrates that a micro loop filament may be used as an alternative surgical approach for energy-free mechanical endocapsular nucleus disassembly and fragmentation.
Use of endo-bronchial end-tidal CO2 test for location of the pleural air leakage in patients with intractable pneumothorax
Authors: Zeng Yi-Ming , Chen Yun-Feng , Lin Hui-Huang , Zhang Xiao-Bin 
Published: February 2018

Background: Location of the affected bronchus of pleural air leaks is the most important step of trans-bronchoscopic bronchial occlusion for the treatment of intractable pneumothorax. The balloon occlusion test is the most commonly used technique, but has failed in some cases. The aim of the present study was: (1) to determine if endo-bronchial end-tidal CO2 (EtCO2) measurement can identify the affected bronchus that is the source of a persistent pleural air leak; and (2) to establish a methodology for endo-bronchial EtCO2 testing in locating affected bronchus in intractable pneumothorax. Methods: A total of 28 patients with intractable pneumothorax underwent bronchoscopy with (1) the balloon occlusion test for the identification of the affected bronchus; and (2) endo-bronchial EtCO2 measurement (EtCO2 test) at the orifices of the bronchus of the affected lung. The effectiveness of these two methods of affected bronchus identification were compared. The threshold EtCO2 (T-EtCO2) was determined. Results: The positive rates of locating the affected bronchus by the endo-bronchial EtCO2 test, balloon occlusion test, and combination of the two techniques were 60.7% (17/28), 64.3% (18/28) and 96.4% (27/28), respectively. The average differences in EtCO2 between the affected bronchus and the main carina, main bronchus, and non-affected bronchus were (in mmHg) 4.41 ± 1.99 (95% confidence interval: 3.5, 5.3), 4.73 ± 2.10 (3.80, 5.66 ) and 5.57 ± 2.53 (4.45, 6.69), respectively. Conclusions: (1) The endo-bronchial EtCO2 test is complementary to the balloon occlusion test of the leading bronchus. (2) A threshold (T-EtCO2) value of >5 mmHg is optimal for this technique.
A Phenomenological Study of the Office Environments of Clinical Social Workers
Authors: Jones Jamie K. 
Published: February 2018

Objective: The purpose of this study was to explore the meaning and uses of the office space among licensed clinical social workers in private practice. Background: Previous research suggests the importance of the office space in clinical practice in regard to therapeutic alliance, client behavior, and the well-being of the therapist. However, therapist offices contain much variation in design. This study looked further into specifically how the therapy room is important through the perspective of the licensed clinical social workers in order to identify common themes. Methods: Seven licensed clinical social workers in private psychotherapy practice were interviewed in their offices. Phenomenological research methods were used to explore and analyze their experiences. Results: While the offices contained many physical differences, the intentions behind the designs were similar. Three themes emerged regarding how participants used and designed their spaces. First, participants used their offices to provide care for clients and themselves. Second, participants used their spaces to communicate therapeutic messages and to reveal and/or conceal aspects of themselves. Third, participants also used their space in direct practice. Conclusion: This phenomenological study provided insight into the importance and use of the psychotherapy office space. These findings may be helpful for therapists designing or redesigning their own practice spaces.