bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights into the Early Evolution of the Côte d'Ivoire Margin (West Africa)
Authors: Scarselli Nicola , Duval Gregor , Martin Javier , McClay Ken , Toothill Steve 
Published: March 2018

Abstract
A tectono-stratigraphic analysis of a broadband 3D seismic survey over the outer slope of Côte d'Ivoire margin, west Africa, revealed that Cenomanian and younger strata seal well-developed rift fault blocks up to 15 km across. Growth strata indicate that these were formed during rifting that culminated in seafloor spreading in the late Albian, challenging existing plate reconstructions for the opening of the equatorial Atlantic ocean. A previously unrecognized system of volcanic edifices linked at depth to a network of sill complexes has also been identified. These are aligned along a NE–SW trend, concordant with kilometre-wide ridges, interpreted as folds formed by steep, crustal faults with an oblique-slip component. These trends are similar to those of fracture zones in the region and indicate that the Côte d'Ivoire was a transform margin in the late Albian. These results highlight the potential of offshore Côte d'Ivoire for deep-water rift plays with large traps formed by extensional fault blocks together with prospective Albian reservoirs ponded in their hanging walls. In addition, the volcanoes and ridges generated seabed relief along the newly created transform margin, forming confined basins for potential deposition of Turonian and younger turbidites and the generation of stratigraphic traps.
Revisiting Interleukin-12 as a Cancer Immunotherapy Agent
Authors: Berraondo Pedro , Etxeberria Iñaki , Ponz-Sarvise Mariano , Melero Ignacio 
Published: March 2018

Abstract
IL12 antitumor activities are mediated by the activation of T and natural killer (NK) lymphocytes to produce IFNγ. Systemically, recombinant IL12 has a narrow therapeutic window that favors local delivery, for instance, by gene therapy approaches. IL12 is a powerful partner in immunotherapy combinations with checkpoint inhibitors and adoptive T-cell transfer. Clin Cancer Res; 24(12); 2716–8. ©2018 AACR.
See related article by Hu et al., p. 2920
β4-Integrin/PI3K Signaling Promotes Tumor Progression through the Galectin-3–N-Glycan Complex
Authors: Kariya Yukiko , Oyama Midori , Hashimoto Yasuhiro , Gu Jianguo , Kariya Yoshinobu 
Published: March 2018

Abstract
Malignant transformation is associated with aberrant N-glycosylation, but the role of protein N-glycosylation in cancer progression remains poorly defined. β4-integrin is a major carrier of N-glycans and is associated with poor prognosis, tumorigenesis, and metastasis. Here, N-glycosylation of β4-integrin contributes to the activation of signaling pathways that promote β4-dependent tumor development and progression. Increased expression of β1,6GlcNAc-branched N-glycans was found to be colocalized with β4-integrin in human cutaneous squamous cell carcinoma tissues, and that the β1,6GlcNAc residue was abundant on β4-integrin in transformed keratinocytes. Interruption of β1,6GlcNAc-branching formation on β4-integrin with the introduction of bisecting GlcNAc by N-acetylglucosaminyltransferase III overexpression was correlated with suppression of cancer cell migration and tumorigenesis. N-Glycan deletion on β4-integrin impaired β4-dependent cancer cell migration, invasion, and growth in vitro and diminished tumorigenesis and proliferation in vivo. The reduced abilities of β4-integrin were accompanied with decreased phosphoinositol-3 kinase (PI3K)/Akt signals and were restored by the overexpression of the constitutively active p110 PI3K subunit. Binding of galectin-3 to β4-integrin via β1,6GlcNAc-branched N-glycans promoted β4-integrin–mediated cancer cell adhesion and migration. In contrast, a neutralizing antibody against galectin-3 attenuated β4-integrin N-glycan–mediated PI3K activation and inhibited the ability of β4-integrin to promote cell motility. Furthermore, galectin-3 knockdown by shRNA suppressed β4-integrin N-glycan–mediated tumorigenesis. These findings provide a novel role for N-glycosylation of β4-integrin in tumor development and progression, and the regulatory mechanism for β4-integrin/PI3K signaling via the galectin-3–N-glycan complex.
Implications: N-Glycosylation of β4-integrin plays a functional role in promoting tumor development and progression through PI3K activation via the galectin-3–N-glycan complex. Mol Cancer Res; 16(6); 1024–34. ©2018 AACR.
Idiopathic Ventricular Arrhythmias Originating From the Infundibular Muscles
Authors: Yamada Takumi , Yoshida Naoki , Litovsky Silvio H. , Itoh Taihei , Doppalapudi Harish , Kay G. Neal 
Published: March 2018

Background:
This study investigated the prevalence, electrocardiographic and electrophysiological characteristics, and ablation outcome of idiopathic ventricular arrhythmias (VAs) originating from the infundibular muscles (IFMs) in the right ventricle consisting of the parietal band (PB) and septal band (SB).

Methods and Results:
We studied 19 patients with idiopathic VA origins in the PB in 14 and SB in 5 among 294 consecutive patients with VA origins in the right ventricle. PB and SB VAs exhibited left bundle branch block with a left inferior (n=12) or superior (n=2) axis and left (n=4) or right inferior (n=1) axis pattern, respectively. In lead I, all PB VAs exhibited R waves while SB VAs often exhibited S waves. A QS pattern in lead aVR and the presence of a notch in the mid-QRS were common in all IFMs VAs. During IFMs VAs, a far-field ventricular electrogram with an early activation was always recorded in the His bundle region regardless of the location of the VA origins. With 9.2±6.9 radiofrequency applications and a duration of 972±946 seconds, catheter ablation was successful in 15 patients. VAs recurred in 4 during a follow-up period of 43±24 months. A change in the QRS morphology was observed spontaneously in 5 patients, immediately after ablation in 4, and at the time of the VA recurrence in 2.

Conclusions:
Idiopathic VAs originating from the IFMs are rare (PB>SB). Catheter ablation of these IFMs VAs was challenging, requiring a large amount of the radiofrequency energy delivery for a successful ablation with a relatively high recurrence rate.
No Benefit of Ticagrelor Pretreatment Compared With Treatment During Percutaneous Coronary Intervention in Patients With ST-Segment–Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Authors: Koul Sasha , Smith J. Gustav , Götberg Matthias , Omerovic Elmir , Alfredsson Joakim , Venetsanos Dimitrios , Persson Jonas , Jensen Jens , Lagerqvist Bo , Redfors Björn , James Stefan , Erlinge David 
Published: March 2018

Background—
The effects of ticagrelor pretreatment in patients with ST-segment–elevation myocardial infarction undergoing primary percutaneous coronary intervention (PCI) is debated. This study investigated the effects of ticagrelor pretreatment on clinical outcomes in this patient group.

Methods and Results—

Patients with ST-segment–elevation myocardial infarction undergoing primary PCI were included from October 2010 to October 2014 in Sweden. Screening was done using the SWEDEHEART register (Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies). A total of 7433 patients were included for analysis with 5438 patients receiving ticagrelor pretreatment and 1995 patients with ticagrelor given only in the catheterization laboratory. The primary end point of the study was 30-day event rates of a composite of all-cause mortality, myocardial infarction (MI), and stent thrombosis. Secondary end points were mortality, MI, or stent thrombosis alone and major in-hospital bleeding. Crude event rates showed no difference in 30-day composite end point (6.2% versus 6.5%;
P=0
.69), mortality (4.5% versus 4.7%;
P=0
.86), MI (1.6% versus 1.7%;
P=0
.72), or stent thrombosis (0.5% versus 0.4%;
P=0
.80) with ticagrelor pretreatment. Three different statistical models were used to correct for baseline differences. No difference in the composite end point, mortality, MI, or stent thrombosis was seen between the 2 groups after statistical adjustment. No increase in in-hospital major bleeding rate was observed with ticagrelor pretreatment.

Conclusions—
Ticagrelor pretreatment versus ticagrelor given in the catheterization laboratory in patients with ST-segment–elevation myocardial infarction undergoing primary PCI did not improve the composite end point of all-cause mortality or MI or stent thrombosis or its individual components at 30 days.
Incidence, Patterns, and Impact of Dual Antiplatelet Therapy Cessation Among Patients With and Without Chronic Kidney Disease Undergoing Percutaneous Coronary Intervention
Authors: Baber Usman , Li Shawn X. , Pinnelas Rebecca , Pocock Stuart J. , Krucoff Mitchell W. , Ariti Cono , Gibson C. Michael , Steg Philippe Gabriel , Weisz Giora , Witzenbichler Bernhard , Henry Timothy D. , Kini Annapoorna S. , Stuckey Thomas , Cohen David J. , Iakovou Ioannis , Dangas George , Aquino Melissa B. , Sartori Samantha , Chieffo Alaide , Moliterno David J. , Colombo Antonio , Mehran Roxana 
Published: March 2018

Background—
Patients with chronic kidney disease (CKD) experience high rates of ischemic and bleeding events after percutaneous coronary intervention (PCI), complicating decisions surrounding dual antiplatelet therapy (DAPT). This study aims to determine the pattern and impact of various modes of DAPT cessation for patients with CKD undergoing PCI.

Methods and Results—
Patients from the PARIS registry (Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients) were grouped based on the presence of CKD defined as creatinine clearance <60 mL/min. After index PCI, time and mode of DAPT cessation (discontinuation, interruption, and disruption) and clinical outcomes (major adverse cardiac events, stent thrombosis, myocardial infarction, and major bleeding [Bleeding Academic Research Consortium type 3 or 5]) were reported. Over 2 years, patients with CKD (n=839) had higher adjusted risks for death (hazard ratio, 3.16; 95% confidence interval, 2.26–4.41), myocardial infarction (hazard ratio, 2.43; 95% confidence interval, 1.65–3.57), and major bleeding (hazard ratio, 2.21; 95% confidence interval, 1.53–3.19) compared with patients without CKD (n=3745). Rates of DAPT discontinuation within the first year after PCI and disruption were significantly higher for patients with CKD. However, DAPT interruption occurred with equal frequency. Associations between DAPT cessation mode and subsequent risk were not modified by CKD status. Findings were unchanged after propensity matching.

Conclusions—
Patients with CKD display high and comparable risks for both ischemic and bleeding events after PCI. Physicians are more likely to discontinue DAPT within the first year after PCI among patients with CKD, likely reflecting clinical preferences to avoid bleeding. Risks after DAPT cessation, irrespective of underlying mode, are not modified by the presence or absence of CKD.
Catheter-Based Measurements of Absolute Coronary Blood Flow and Microvascular Resistance
Authors: Xaplanteris Panagiotis , Fournier Stephane , Keulards Daniëlle C.J. , Adjedj Julien , Ciccarelli Giovanni , Milkas Anastasios , Pellicano Mariano , van’t Veer Marcel , Barbato Emanuele , Pijls Nico H.J. , De Bruyne Bernard 
Published: March 2018

Background—
The principle of continuous thermodilution can be used to calculate absolute coronary blood flow and microvascular resistance (R). The aim of the study is to explore the safety, feasibility, and reproducibility of coronary blood flow and R measurements as measured by continuous thermodilution in humans.

Methods and Results—

Absolute coronary flow and R can be calculated by thermodilution by infusing saline at room temperature through a dedicated monorail catheter. The temperature of saline as it enters the vessel, the temperature of blood and saline mixed in the distal part of the vessel, and the distal coronary pressure were measured by a pressure/temperature sensor-tipped guidewire. The feasibility and safety of the method were tested in 135 patients who were referred for coronary angiography. No significant adverse events were observed; in 11 (8.1%) patients, bradycardia and concomitant atrioventricular block appeared transiently and were reversed immediately on interruption of the infusion. The reproducibility of measurements was tested in a subgroup of 80 patients (129 arteries). Duplicate measurements had a strong correlation both for coronary blood flow (ρ=0.841,
P
<0.001; intraclass correlation coefficient=0.89,
P
<0.001) and R (ρ=0.780,
P
<0.001; intraclass correlation coefficient=0.89,
P
<0.001). In Bland–Altman plots, there was no significant bias or asymmetry.

Conclusions—
Absolute coronary blood flow (in L/min) and R (in mm Hg/L/min or Wood units) can be safely and reproducibly measured with continuous thermodilution. This approach constitutes a new opportunity for the study of the coronary microcirculation.
Traditional Chinese Medicine for Acute Myocardial Infarction in Western Medicine Hospitals in China
Authors: Spatz Erica S. , Wang Yongfei , Beckman Adam L. , Wu Xuekun , Lu Yuan , Du Xue , Li Jing , Xu Xiao , Davidson Patricia M. , Masoudi Frederick A. , Spertus John A. , Krumholz Harlan M. , Jiang Lixin 
Published: March 2018

Background:
Amid national efforts to improve the quality of care for people with cardiovascular disease in China, the use of traditional Chinese medicine (TCM) is increasing, yet little is known about its use in the early management of acute myocardial infarction (AMI).

Methods and Results:

We aimed to examine intravenous use of TCM within the first 24 hours of hospitalization (early IV TCM) for AMI. Data come from the China Patient-centered Evaluative Assessment of Cardiac Events Retrospective Study of Acute Myocardial Infarction, restricted to a large, representative sample of Western medicine hospitals throughout China (n=162). We conducted a chart review of randomly sampled patients with AMI in 2001, 2006, and 2011, comparing early intravenous TCM use across years, predictors of any early intravenous TCM use, and association with in-hospital bleeding and mortality. From 2001 to 2011, early intravenous TCM use increased (2001: 38.2% versus 2006: 49.1% versus 2011: 56.1%;
P
<0.01). Nearly all (99%) hospitals used early intravenous TCM. Salvia miltiorrhiza was most commonly prescribed, used in one third (35.5%) of all patients admitted with AMI. Patients receiving any early intravenous TCM, compared with those who did not, were similar in age and sex and had fewer cardiovascular risk factors. In multivariable hierarchical models, admission to a secondary (versus tertiary) hospital was most strongly associated with early intravenous TCM use (odds ratio: 2.85; 95% confidence interval: 1.98–4.11). Hospital-level factors accounted for 55% of the variance (adjusted median odds ratio: 2.84). In exploratory analyses, there were no significant associations between early intravenous TCM and in-hospital bleeding or mortality.

Conclusions:
Early intravenous TCM use for AMI in China is increasing despite the lack of evidence of their benefit or harm. There is an urgent need to define the effects of these medications because they have become a staple of treatment in the world’s most populous country.

CLINICAL TRIAL REGISTRATION:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT01624883
Long‐Term Outcomes of Tricuspid Valve Surgery in Patients With Congenitally Corrected Transposition of the Great Arteries
Authors: Deng Long , Xu Jianping , Tang Yajie , Sun Hansong , Liu Sheng , Song Yunhu 
Published: March 2018

Background
Valvuloplasty is generally considered unsuccessful in patients with congenitally corrected transposition of the great arteries. Optimal timing of tricuspid valve surgery in these patients is crucial.

Methods and Results

We retrospectively reviewed 57 patients with congenitally corrected transposition of the great arteries undergoing tricuspid valve surgery at our institution. Eleven patients had tricuspid valve plasty and 46 had tricuspid valve replacement. Mean duration of follow‐up was 7.4±5.5 years in the group of tricuspid valve plasty and 5.6±3.6 years in the group of tricuspid valve replacement, respectively (
P
=0.33). For the total of 57 patients, estimates of 1‐, 5‐, and 10‐year survival or freedom from transplantation were 96.4%, 91.6%, and 75.6%, respectively. Late right ventricular ejection fraction of most patients (90%) remained preserved (≥40%) during the follow‐up. In a highly selected group of tricuspid valve plasty recipients, although long‐term survival and right ventricular function were similar compared with tricuspid valve replacement, recurrent tricuspid regurgitation was observed in 60% of these patients. Multivariate Cox regression analysis identified preoperative right ventricular end‐diastolic dimension (1‐cm increment; harzard ratio, 3.22;
P
=0.02) as an independent predictor of postoperative mortality or need for transplantation. Patients undergoing surgery with a right ventricular end‐diastolic dimension ≥60 mm had a significant lower survival rate compared with those with a right ventricular end‐diastolic dimension <60 mm (
P
=0.003).

Conclusions
Tricuspid valve surgery in patients with congenitally corrected transposition of the great arteries could yield satisfactory long‐term outcomes. Recurrent tricuspid regurgitation was frequently observed in tricuspid valve plasty recipients. Preoperative right ventricular end‐diastolic dimension was a risk factor for late mortality and surgery should be performed before cardiac enlargement and dysfunction for best outcomes.
Workers beneath the Floodgates: Low-Wage Import Competition and Workers’ Adjustment
Authors: Utar Hale 
Published: March 2018

Abstract
Using employee-employer matched data, I analyze the impact of a low-wage trade shock on manufacturing workers in a high-wage country, Denmark, and how they adjust to the shock over a decade. I derive causal effects by exploiting the dismantling of the Multifiber Arrangement quotas on products from China upon its WTO accession as a quasi-natural experiment and use within-industry, within-occupation heterogeneity in workers’ exposure to this shock. I find significant negative long-run effects on earnings and employment trajectories and identify job instability in the service sector as a main adjustment friction, concentrated among workers with manufacturing-specific education and occupation. The results establish the importance of specific human capital in trade adjustment and provide evidence of skill upgrading as workers rebuild lost human capital through education.
Demand Learning and Firm Dynamics: Evidence from Exporters
Authors: Berman Nicolas , Rebeyrol Vincent , Vicard Vincent 
Published: March 2018

Abstract
This paper provides direct evidence that learning about demand is an important driver of firms’ dynamics. We present a model of Bayesian learning in which firms are uncertain about idiosyncratic demand in each market and update their beliefs as noisy information arrives. Firms update their beliefs to a given demand shock more, the younger they are. We test and empirically confirm this prediction, using the structure of the model, together with exporter-level data, to identify demand shocks and the firms’ beliefs about future demand. Consistent with theory, we also find the learning process to be weakened in more uncertain environments.
Environmental Engel Curves: Indirect Emissions of Common Air Pollutants
Authors: Levinson Arik , O’Brien James 
Published: March 2018

AbstractEnvironmental Engel curves (EECs) describe households’ incomes and the pollution necessary to produce the goods and services they consume. We calculate 29 annual EECs from 1984 to 2012 for point-source air pollutants in the United States, revealing three clear results: EECs slope upward, have income elasticities less than 1, and shift down over time. Even without changes to production techniques, pollution would have declined despite growing incomes. This improvement can be attributed about equally to two trends: household income growth represented by movement along inelastic EECs and economy-wide changes represented by downward shifts in EECs over time.
Rossby Wave Initiation by Recurving Tropical Cyclones in the Western North Pacific
Authors: Riboldi Jacopo , Röthlisberger Matthias , Grams Christian M. 
Published: March 2018

Abstract
The interaction of recurving tropical cyclones (TCs) with midlatitude Rossby waves during extratropical transition (ET) can significantly alter the midlatitude flow configuration. This study provides a climatological investigation of Rossby wave initiation (RWI) by transitioning TCs in the specific configuration of an initially zonal midlatitude waveguide and elucidates physical processes governing ab initio flow amplification during ET. Recurving TCs interacting with a zonally oriented waveguide in the western North Pacific (WNP) basin from 1979 to 2013 are categorized into cases initiating Rossby waves (TC-RWI) or not (TC-noRWI). Interactions with a zonally oriented waveguide occurred for 22.7% of the recurving TCs, and one-third of these resulted in TC-RWI. In the presence of a TC, the probability of RWI on a zonally oriented waveguide is 3 times larger than in situations without a TC. The occurrence of TC-RWI exhibits a seasonality and is relatively more common during boreal summer than in autumn. We further reveal that a strong preexisting upper-level jet stream, embedded in a deformative large-scale flow pattern, hinders TC-RWI as air from the diabatic outflow of the TC is rapidly advected downstream and does not lead to strong ridge building. In contrast, an enhanced monsoon trough favors TC-RWI as the poleward moisture transport strengthens diabatic outflow and leads to strong ridge building during ET. Thus, we conclude that TC-related ab initio flow amplification over the WNP is governed by characteristics of the large-scale flow more so than by characteristics of the recurving TC.
The effect of protamine dosing variation on bleeding and transfusion after heparinisation for cardiopulmonary bypass
Authors: Kunz Stephen A. , Miles Lachlan F , Ianno Damian J , Mirowska-Allen Kelly L , Matalanis George , Bellomo Rinaldo , Seevanayagam Siven 
Published: March 2018

Introduction: Accurate dosing of protamine reversal following on-pump cardiac surgical procedures is challenging, with both excessive and inadequate administration recognised to increase bleeding risk. We aimed to examine the relationship between three ratios for heparin reversal and markers of haemostasis. Methods: A retrospective analysis of a prospectively collected database was undertaken at a single tertiary cardiac unit, reviewing all cases of on-pump coronary artery bypass grafts and single valve replacements from 01/01/2011 to 31/12/2015. The ratio between total intra-operative heparin and protamine was stratified to three groups (low: ≤0.6 mg per 100 IU of heparin, moderate: 0.6-1.0 and high: >1.0) and related to the primary outcome of red blood cell (RBC) transfusion, with secondary outcomes being the number of units transfused, the haemoglobin differential and mediastinal drain output at 4 hours. Results: Of the 803 patients identified, 338 received a blood transfusion, with 1035 units being used. Eighteen percent of individuals (145) received a low ratio, 50% (404) received a moderate ratio and 32% (254) a high ratio. Using the moderate group as a reference, the low dose group was 56.5% less likely to have received a RBC transfusion (OR 0.435; 95% CI 0.270:0.703 p=0.001) while the high dose group carried a 241% increased association with transfusion (OR 3.412; 95% CI 2.399:4.853 p<0.001). For those transfused, a lower protamine:heparin ratio was associated with a lower number of units transfused, lesser haemoglobin differential and less mediastinal drain output. Conclusion: Higher doses of intra-operative protamine relative to heparin are associated with greater risk of transfusion and post-operative bleeding.