bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multifunctional Silicon–Carbon Nanohybrids Simultaneously Featuring Bright Fluorescence, High Antibacterial and Wound Healing Activity
Authors: Hu Guyue , Song Bin , Jiang Airui , Chu Binbin , Shen Xiaobin , Tang Jiali , Su Yuanyuan , He Yao 
Published: January 2019

AbstractIn this work, a class of multifunctional silicon–carbon nanohybrids (designated as SiCNs), which simultaneously possess aqueous dispersibility, bright fluorescence (photoluminescence quantum yield [PLQY]: ≈28%), as well as high antibacterial and wound healing activity, is presented. Taking advantage of these unique merits, cell distribution and pharmacological behavior of the SiCNs is first investigated through tracking their strong and stable fluorescence. The high bacteria inhibition ability (≈82.9% killing rate toward S. aureus) and hemostatic effects (shorten the bleeding time from ≈60 to ≈15 s) of the resultant SiCNs are then demonstrated. Moreover, the wound closure promotion activity (10% lead in wound contraction) is systematically demonstrated in vivo, which is especially suitable for wound healing applications. The results suggest the SiCNs as a new kind of high‐performance multifunctional nanoagents suitable for various biological and biomedical utilizations.
Variability of temperature dependences of the retention of strongly polar compounds under ZIC‐HILIC liquid chromatographic mechanism
Authors: Tanase Maria , Bacalum Elena , David Victor 
Published: January 2019

AbstractThe retentions of 13 strongly polar compounds (aminocids; dipeptides, drugs, and other biologically active species) were studied for two SeQuant ZIC‐HILIC (Merck) stationary phases containing a zwitterionic sulfobetaine moiety covalently attached to porous silica (3.5 and 5 μm particle size). Methanol and acetonitrile were used as organic components in the mobile phase composition, whose aqueous phase consisted in buffers of various controled pH values based on acetate‐acetic acid. This study shows various dependences of the retention on the absolute column temperature, some being obeyed to van't Hoff dependence, while others not following this rule. The values of standard enthalpy for the transfer of the analyte from mobile phase to the stationary phase were calculated from linear van't Hoff plots, which were below 10 kJ/mol. From the polynomial regression applied to the experimental retention data that not obeyed to a linear fit, the value of absolute temperature was calculated that corresponds to a maximum retention for studied compounds.
Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression
Authors: Giannios Ioannis , Serafimidis Ioannis , Anastasiou Vivian , Pezzolla Daniela , Lesche Mathias , Andree Cordula , Bickle Marc , Gavalas Anthony 
Published: January 2019

AbstractUnderstanding the mechanisms that promote the specification of pancreas progenitors and regulate their self-renewal and differentiation will help to maintain and expand pancreas progenitor cells derived from human pluripotent stem (hPS) cells. This will improve the efficiency of current differentiation protocols of hPS cells into β-cells and bring such cells closer to clinical applications for the therapy of diabetes. Aldehyde dehydrogenase 1b1 (Aldh1b1) is a mitochondrial enzyme expressed specifically in progenitor cells during mouse pancreas development, and we have shown that its functional inactivation leads to accelerated differentiation and deficient β-cells. In this report, we aimed to identify small molecule inducers of Aldh1b1 expression taking advantage of a mouse embryonic stem (mES) cell Aldh1b1 lacZ reporter line and a pancreas differentiation protocol directing mES cells into pancreatic progenitors. We identified AMI-5, a protein methyltransferase inhibitor, as an Aldh1b1 inducer and showed that it can maintain Aldh1b1 expression in embryonic pancreas explants. This led to a selective reduction in endocrine specification. This effect was due to a downregulation of Ngn3, and it was mediated through Aldh1b1 since the effect was abolished in Aldh1b1 null pancreata. The findings implicated methyltransferase activity in the regulation of endocrine differentiation and showed that methyltransferases can act through specific regulators during pancreas differentiation. Stem Cells 2019;37:640–651
Induced Pluripotent Stem Cells Regulate Triggering Receptor Expressed on Myeloid Cell-1 Expression and the p38 Mitogen-Activated Protein Kinase Pathway in Endotoxin-Induced Acute Lung Injury
Authors: Su Vincent Yi-Fong , Yang Kuang-Yao , Chiou Shih-Hwa , Chen Nien-Jung , Mo Min-Hsiang , Lin Chi-Shiuan , Wang Chin-Tien 
Published: January 2019

AbstractInduced pluripotent stem cells (iPSCs) can attenuate the pathological severity and neutrophil migration of lipopolysaccharide (LPS)-induced acute lung injury (ALI). However, interactions that may occur between iPSCs and the triggering receptor expressed on myeloid cells (TREM) family of proteins remain unclear. In this study, murine iPSCs (miPSCs) were delivered via tail vein injection to wild type, TREM-1 knockout (KO), and TREM-2 KO C57BL/6 mice 4 hours after an intratracheal delivery of LPS. Twenty-four hours later, the bronchoalveolar lavage fluid and lung tissue were collected to perform histology, immunohistochemistry, neutrophil counts, Western blot assays, and enzyme-linked immunosorbent assays. Neutrophils were also isolated from the bone marrow to perform in vitro migration assays. In the lung tissues collected, LPS increased the expression of TREM-1 and TREM-2, with the TREM-2 KO mice expressing more TREM-1 than the wild-type mice. The TREM-2 KO mice also exhibited greater severity of LPS-induced ALI, enhanced neutrophil infiltration in the lung tissues, and a higher ratio of phosphorylated p38 to total p38 (p-p38/p38) in neutrophils. The p-p38/p38 ratio and the expression of vascular cell adhesion molecule-1 and certain proinflammatory cytokines (macrophage inflammatory protein-2, tumor necrosis factor-α, interleukin-6, and interleukin-1β) were increased in whole lung extracts following LPS-induced ALI, and these levels were even more in LPS-treated TREM-2 KO mice. These effects were reduced when miPSCs were administered. Thus, the results of this study suggest that miPSCs attenuate the role of neutrophils in lung inflammation and injury induced by LPS by reducing their expression of TREM-1 and p38 mitogen-activated protein kinase signaling. Stem Cells 2019;37:631–639
Reappraisal of Prognostic Impact of Tumor SUVmax by 18F‐FDG‐PET/CT in Intrahepatic Cholangiocarcinoma
Authors: Yoh Tomoaki , Seo Satoru , Morino Koshiro , Fuji Hiroaki , Ikeno Yoshinobu , Ishii Takamichi , Taura Kojiro , Nakamoto Yuji , Higashi Tatsuya , Kaido Toshimi , Uemoto Shinji 
Published: January 2019

AbstractBackgroundWe previously reported that tumor standardized uptake value (SUVmax) by 18F‐fluorodeoxyglucose‐positron emission tomography/computed tomography (PET/CT) was a potential predictor in patients undergoing surgery for intrahepatic cholangiocarcinoma (ICC). However, the prognostic value of SUVmax in the era of multidisciplinary strategy has remained unclear. The aim of this study was to reappraise the prognostic value of tumor SUVmax in patients undergoing surgery for ICC.MethodsData from 82 consecutive ICC patients, who underwent 18F‐FDG‐PET/CT and subsequent surgery between 2006 and 2017, were retrieved from a prospectively maintained institutional database. Adjuvant strategy was administrated during this study period in our center.ResultsTumor SUVmax was associated with tumor size (p = 0.002) and tumor number (p = 0.005), but not associated with T and N stage classified by American Joint Committee on Cancer‐classification system, and other tumor factors. According to the tumor SUVmax cut‐off values of 8.0 based on the minimum p value approach, actuarial 5‐year overall survival (OS) rates in patients undergoing upfront surgery for ICC were significantly stratified at 54.7% versus 26.0% (low vs. high tumor SUVmax group, p = 0.008). The actuarial 3‐year disease‐free survival (DFS) rates were also significantly stratified at 41.0% versus 18.3% (p < 0.001). Multivariate Cox regression analyses revealed that tumor SUVmax retained its significance on OS (p = 0.039) as well as DFS (p < 0.001).ConclusionEven in the era of multidisciplinary strategy, high tumor SUVmax still represents poor prognosis in patients undergoing surgery for ICC. These patients, therefore, would probably be required more effective strategies.
A selective genome-guided method for environmental Burkholderia isolation
Authors: Haeckl F P Jake , Baldim João L , Iskakova Dasha , Kurita Kenji L , Soares Marisi G , Linington Roger G 
Published: January 2019

Abstract
The genus Burkholderia is an emerging source of novel natural products chemistry, yet to date few methods exist for the selective isolation of strains of this genus from the environment. More broadly, tools to efficiently design selection media for any given genus would be of significant value to the natural products and microbiology communities. Using a modification of the recently published SMART protocol, we have developed a two-stage isolation protocol for strains from the genus Burkholderia. This method uses a combination of selective agar isolation media and multiplexed PCR profiling to derive Burkholderia strains from environmental samples with 95% efficiency. Creation of this new method paves the way for the systematic exploration of natural products chemistry from this important genus and offers new insight into potential methods for selective isolation method development for other priority genera.
The temporal association between emotional clarity and depression symptoms in adolescents
Authors: Blöte Anke W. , Westenberg P. Michiel 
Published: January 2019

ABSTRACTIntroductionLow emotional clarity, that is, problems in understanding and identifying one's own emotions, is generally seen as related to depression. Most empirical studies on this topic focused on the link between low levels of emotional clarity predicting depression problems, fewer studies on depression symptoms predicting low emotional clarity. All studies were restricted to unidirectional associations. The present study evaluated the reciprocal associations between emotional clarity and depression symptoms. Additionally, we tested the role of rumination as a mediator of the links between depression symptoms and emotional clarity.MethodsFor the main analyses, data of 230 Dutch participants (Mage = 13.40, SD = 2.24; 48% girls) over three time points of a 5‐year longitudinal study were used. Depression symptoms, emotional clarity, and rumination were self‐reported. Cross‐lagged panel analysis was used to test a model of reciprocal associations between depression symptoms and emotional clarity against models of unidirectional associations. The role of rumination as mediator and sex as moderator in the links between depression symptoms and emotional clarity were evaluated in separate analyses on a subsample (n = 151).Results & conclusionsA model of reciprocal associations where depression symptoms and low emotional clarity predict relatively high scores of the other over time offered a good representation of the data. Rumination mediated the link between depression symptoms predicting prospective emotional clarity for both sexes. These findings suggest a vicious cycle between depression symptoms and low emotional clarity. We discuss possible implications of these results for the treatment of depression in youth.
A THEORY OF PAIRS FOR NON-VALUATIONAL STRUCTURES
Authors: BAR-YEHUDA ELITZUR , HASSON ASSAF , PETERZIL YA’ACOV 
Published: January 2019

AbstractGiven a weakly o-minimal structure${\cal M}$and its o-minimal completion$\bar{{\cal M}}$, we first associate to$\bar{{\cal M}}$a canonical language and then prove thatTh$\left( {\cal M} \right)$determines$Th\left( {\bar{{\cal M}}} \right)$. We then investigate the theory of the pair$\left( {\bar{{\cal M}},{\cal M}} \right)$in the spirit of the theory of dense pairs of o-minimal structures, and prove, among other results, that it is near model complete, and every definable open subset of${\bar{M}^n}$is already definable in$\bar{{\cal M}}$.We give an example of a weakly o-minimal structure interpreting$\bar{{\cal M}}$and show that it is not elementarily equivalent to any reduct of an o-minimal trace.
Predictive value of hyoid cephalometrics for retroglossal obstruction in patients with obstructive sleep apnoea hypopnea syndrome
Authors: Hei R Y , Qin J , Li S H 
Published: January 2019

AbstractObjectiveTo examine the diagnostic value of hyoid cephalometrics in predicting retroglossal obstruction severity in patients with obstructive sleep apnoea hypopnea syndrome.MethodsNinety-six obstructive sleep apnoea hypopnea syndrome patients diagnosed by polysomnography were recruited. Polysomnography was repeated with a nasopharyngeal tube after eliminating rhinal and palatopharyngeal obstruction. Cervical vertebra lateral films and hyoid cephalometric measurements were obtained, including the distances of the hyoid to the: mental tubercle, prevertebral plane, mental tubercle coronal plane and mental tubercle horizontal plane.ResultsThe apnoea-hypopnoea index for nasopharyngeal tube polysomnography was significantly correlated with distances from the hyoid to: prevertebral plane (r = 0.350), coronal plane (r = 0.477), horizontal plane (r = 0.529) and mental tubercle (r = 0.560). It was strongly correlated with the hyoid to mental tubercle distance/hyoid to prevertebral plane distance value (r = 0.683), and (hyoid to coronal plane distance plus hyoid to horizontal plane distance)/hyoid to prevertebral plane distance value (r = 0.675).ConclusionObstructive sleep apnoea hypopnea syndrome patients with longer hyoid to mental tubercle distances, and/or more inferior and posterior hyoid bone position, are more prone to retroglossal stenosis and obstruction. Hyoid cephalometrics are valuable for predicting retroglossal obstruction severity.
Diabetes, undernutrition, migration and indigenous communities: tuberculosis in Chiapas, Mexico
Authors: Rashak H. A. , Sánchez-Pérez H. J. , Abdelbary B. E. , Bencomo-Alerm A. , Enriquez-Ríos N. , Gómez-Velasco A. , Colorado A. , Castellanos-Joya M. , Rahbar M. H. , Restrepo B. I. 
Published: January 2019

AbstractWe investigated the distribution of comorbidities among adult tuberculosis (TB) patients in Chiapas, the poorest Mexican state, with a high presence of indigenous population, and a corridor for migrants from Latin America. Secondary analysis on 5508 new adult TB patients diagnosed between 2010 and 2014 revealed that the most prevalent comorbidities were diabetes mellitus (DM; 19.1%) and undernutrition (14.4%). The prevalence of DM in these TB patients was significantly higher among middle aged (41–64 years) compared with older adults (⩾65 years) (38.6% vs. 23.2%; P < 0.0001). The prevalence of undernutrition was lower among those with DM, and higher in communities with high indigenous presence. Immigrants only comprised 2% of all TB cases, but were more likely to have unfavourable TB treatment outcomes (treatment failure, death and default) when compared with those born in Chiapas (29.5% vs. 11.1%; P < 0.05). Unfavourable TB outcomes were also more prevalent among the TB patients with undernutrition, HIV or older age, but not DM (P < 0.05). Our study in Chiapas illustrates the challenges of other regions worldwide where social (e.g. indigenous origin, poverty, migration) and host factors (DM, undernutrition, HIV, older age) are associated with TB. Further understanding of these critical factors will guide local policy makers and health providers to improve TB management.
Rapid development of pulmonary hypertension during treatment of paediatric cancer
Authors: Aggarwal Manish , Schuettpelz Laura , Kolodziej Julie , Grady R. Mark 
Published: January 2019

AbstractPaediatric pulmonary hypertension has been described as a secondary complication of multiple diseases and their treatment. Limited information exists about the relationship between pulmonary hypertension and cancer in children. A review of charts was performed in all patients treated for cancer and developed pulmonary hypertension. A total of four patients developed pulmonary hypertension during treatment of cancer. All patients had solid tumors, had echocardiographic evidence of elevated right ventricular pressures, and required intensive care stays. Treatment courses included inhaled and oral pulmonary vasodilators along with systemic steroids. Each had normalisation of echocardiograms and resolution of pulmonary symptoms. Prompt diagnosis of pulmonary hypertension and treatment with pulmonary vasodilators and steroids are considered important measures followed by chemotherapy and radiation regimens.
Transient left bundle branch block and left ventricular dysfunction in a patient with NLRP1-associated autoinflammation with arthritis and dyskeratosis syndrome
Authors: Garrelfs Mark R. , Hoppenreijs Esther , Tanke Ronald B. 
Published: January 2019

AbstractThe NLRP1-associated autoinflammation with arthritis and dyskeratosis syndrome is a rare novel autoinflammatory disorder. Cardiac involvement has not been previously reported. We present a 12-year-old girl with NLRP1-associated autoinflammation with arthritis and dyskeratosis syndrome who was diagnosed with severely impaired left ventricular function and complete left bundle branch block during an exacerbation of the disease. Cardiac dysfunction proved to be rapidly reversible after initiation of high-dose methylprednisolone.
Theta-Band Functional Connectivity and Single-Trial Cognitive Control in Sports-Related Concussion: Demonstration of Proof-of-Concept for a Potential Biomarker of Concussion
Authors: Smith Ezra E. , Allen John J.B. 
Published: January 2019

AbstractObjectives:This report examined theta-band neurodynamics for potential biomarkers of brain health in athletes with concussion.Methods:Participants included college-age contact/collision athletes with (N=24) and without a history of concussion (N=16) in Study 1. Study 2 (N=10) examined changes over time in contact/collision athletes. There were two primary dependent variables: (1) theta-band phase-synchronization (e.g., functional connectivity) between medial and right-lateral electrodes; and (2) the within-subject correlation between synchronization strength on error trials and post-error reaction time (i.e., operationalization of cognitive control).Results:Head injury history was inversely related with medial-lateral connectivity. Head injury was also related to declines in a neurobehavioral measure of cognitive control (i.e., the single-trial relationship between connectivity and post-error slowing).Conclusions:Results align with a theory of connectivity-mediated cognitive control. Mild injuries undetectable by behavioral measures may still be apparent on direct measures of neural functioning. This report demonstrates that connectivity and cognitive control measures may be useful for tracking recovery from concussion. Theoretically relevant neuroscientific findings in healthy adults may have applications in patient populations, especially with regard to monitoring brain health. (JINS2019,25, 314–323)
Satellite Observations of the Contrasting Response of Trees and Grasses to Variations in Water Availability
Authors: Walther Sophia , Duveiller Gregory , Jung Martin , Guanter Luis , Cescatti Alessandro , Camps‐Valls Gustau 
Published: January 2019

AbstractInterannual variations in ecosystem primary productivity are dominated by water availability. Until recently, characterizing the photosynthetic response of different ecosystems to soil moisture anomalies was hampered by observational limitations. Here, we use a number of satellite‐based proxies for productivity, including spectral indices, sun‐induced chlorophyll fluorescence, and data‐driven estimates of gross primary production, to reevaluate the relationship between terrestrial photosynthesis and water. In contrast to nonwoody vegetation, we find a resilience of forested ecosystems to reduced soil moisture. Sun‐induced chlorophyll fluorescence and data‐driven gross primary production indicate an increase in photosynthesis as a result of the accompanying higher amounts of light and temperature despite lowered light‐use‐efficiency. Conversely, remote sensing indicators of greenness reach their detection limit and largely remain stable. Our study thus highlights the differential responses of ecosystems along a tree cover gradient and illustrates the importance of differentiating photosynthesis indicators from those of greenness for the monitoring and understanding of ecosystems.
Forest Drought Resistance at Large Geographic Scales
Authors: Brodrick P. G. , Anderegg L. D. L. , Asner G. P. 
Published: January 2019

AbstractForest conservation and carbon sequestration efforts are on the rise, yet the long‐term stability of these efforts under a changing climate remains unknown. We generate nearly three decades of remotely sensed canopy water content throughout California, which we use to determine patterns of drought stress. Linking these patterns of drought stress with meteorological variables enables us to quantify spatially explicit biophysical drought resistance in terms of magnitude and duration. These maps reveal significant spatial heterogeneity in drought resistance and demonstrate that almost all forests have less resistance to severe, persistent droughts. By identifying the spatial patterning of biophysical drought resistance, we quantify an important component of long‐term ecosystem stability that can be used for forest conservation, management, and policy decisions.
Microbial and Geochronologic Constraints on the Neogene Paleotopography of Northern Tibetan Plateau
Authors: Zhuang Guangsheng , Zhang Yi Ge , Hourigan Jeremy , Ritts Bradley , Hren Michael , Hou Mingqiu , Wu Minghao , Kim Bumsoo 
Published: January 2019

AbstractHigh topography is the manifestation of the balance between deep and surficial erosional processes. Hence, reconstructions of paleotopography are critical for disentangling records of orogenesis and climate. Here we used a new approach by combining detrital zircon U‐Pb geochronology and tetraether‐based paleothermometry to characterize the Neogene paleotopography of Northern Tibetan Plateau. Detrital zircon U‐Pb data reveal that the Qilian Shan has been uplifted, providing sediments to bounding basins since circa 15.8 Ma. The paleothermometry studies show warm temperatures for paleosols (<12.4–9.5 Ma and 3.7–2.0 Ma) and low temperatures for lacustrine facies (12.4 Ma and 9.5–3.7 Ma). We interpret the different temperatures to reflect the in situ production of tetraethers under warm temperatures within the basin (paleosols) versus terrestrial inputs from high and cold drainage to the paleolake (lacustrine facies). The study supports a topography with significant relief in the Northern Tibetan Plateau since 12.4 Ma.