bluuebunny/crossref_metadata_2025_split huggingface dataset:
65nm CMOS phase conjugator for retro‐directive short‐range wireless power transfer
Authors: Lim Joo‐Hwan , Kim Wan‐Su , Doan Nhut‐Tan , Lai Ngoc‐Duy‐Hien , Ngo Tan‐Binh , Kim Chang‐Woo , Yoon Sang‐Woong 
Published: January 2019

AbstractWe present an ultra‐compact phase conjugator for a radio frequency (RF) system of a retro‐directive array (RDA) that is, suitable for a short‐range wireless power transfer (WPT) application. The proposed phase conjugator consists of a mixer, buffer, and limiter, and provides not only an accurate conjugate phase but also small jitter, variable gain, and linear phase characteristics. The phase conjugator was implemented using Samsung 65 nm RF CMOS technology. The size of the core chip was 1150 × 880 μm2. The circuit used a supply voltage of 1.4 V and a current of 10 mA. All ports are matched to 50 Ω. In the measurements, the RF, intermediate frequency (IF), and local oscillator (LO) frequency of the mixer are 2.5, 2.4, and 4.9 GHz, respectively. The phase conjugator provides an excellent RF‐IF isolation of less than −45 dB and small RMS jitter of less than 4.3 ps. The limiter enables the phase conjugator to exhibit a constant phase of 168.1 ± 0.10 and a constant output power of about −22.5 ± 0.3 dBm in the input power range from −10 dBm to 0 dBm.
Graphene‐based tunable near‐infrared absorber
Authors: Thomas Leena , Sorathiya Vishal , Patel Shobhit K. , Guo Tianjing 
Published: January 2019

AbstractWe propose design of tunable high sensitive absorber for infrared spectrum using graphene layer. Proposed absorber structure is tunable over near‐infrared region of 900‐1000 nm. Tunability of reflector is achieved by different chemical potential of graphene. Parameters like absorption and reflectance of the design has been analyzed for varying chemical potential of graphene. Maximum absorption of 99.2% for chemical potential of 0.4 eV at 955.5 nm has been observed. Such features of the design can be implemented for applications like biomedical sensor and optical communication.
Miniaturized bandpass filter design using substrate integrated waveguide cavities with enhanced signal selectivity
Authors: Ho Min‐Hua , Lee Keh‐Yi , Chen Yi‐Cheng 
Published: January 2019

AbstractWe propose a miniaturized bandpass filter (BPF) design with enhanced signal selectivity performance. The proposed structure is composed of four square substrate integrated waveguide cavities (SIWCs). To miniaturize its circuit size, the applied cavities are under the evanescent mode resonance which is accomplished by loaded itself with a large capacitance. As a result, a 93.4% size reduction is achieved. The negative coupling structure is employed in the filter design to create two transmission zeroes by the pass band's two edges for enhancing the signal selectivity. Experiment is conducted to verify this compact SIWC BPF design.
Compact wideband tapered‐fed printed bow‐tie antenna with rectangular edge extension
Authors: Bozdag Goksenin , Secmen Mustafa 
Published: January 2019

AbstractIn this article, a wideband printed bow‐tie antenna is designed entire band of GPS (L5), PCS, IMT‐2000, Bluetooth, Wi‐Fi, WiMAX bands, and the most of frequency range of UWB. Apart from the traditional designs, the proposed antenna includes tapered printed line with a feeding point patch and triangular bows with rectangular edge extensions, which makes the antenna more compact. The antenna realized at the frequency band of 1.49‐9.5 GHz (more than 6.3:1 ratio bandwidth) has the dimensions of 122 mm × 56 mm (0.61λ0 × 0.28λ0). According to measurement results, the realized gain varies between almost 1 and 6.5 dBi with 4.44 dBi average, which are in good agreement with simulation results. Radiation patterns at the lower frequencies of operating band show dipole like radiation pattern with higher cross‐pol discrimination levels while they degrade at the higher frequencies due to increase in gain.
Efficient shear wave elastography using transient acoustic radiation force excitations and MR displacement encoding
Authors: Hofstetter Lorne W. , Odéen Henrik , Bolster Bradley D. , Mueller Alexander , Christensen Douglas A. , Payne Allison , Parker Dennis L. 
Published: January 2019

PurposeTo present a novel MR shear wave elastography (MR‐SWE) method that efficiently measures the speed of propagating wave packets generated using acoustic radiation force (ARF) impulses.MethodsARF impulses from a focused ultrasound (FUS) transducer were applied sequentially to a preselected set of positions and motion encoded MRI was used to acquire volumetric images of the propagating shear wavefront emanating from each point. The wavefront position at multiple propagation times was encoded in the MR phase image using a train of motion encoding gradient lobes. Generating a transient propagating wavefront at multiple spatial positions and sampling each at multiple time‐points allowed for shear wave speed maps to be efficiently created. MR‐SWE was evaluated in tissue mimicking phantoms and ex vivo bovine liver tissue before and after ablation.ResultsMR‐SWE maps, covering an in‐plane area of ~5 × 5 cm, were acquired in 12 s for a single slice and 144 s for a volumetric scan. MR‐SWE detected inclusions of differing stiffness in a phantom experiment. In bovine liver, mean shear wave speed significantly increased from 1.65 ± 0.18 m/s in normal to 2.52 ± 0.18 m/s in ablated region (n = 581 pixels; P‐value < 0.001).ConclusionMR‐SWE is an elastography technique that enables precise targeting and excitation of the desired tissue of interest. MR‐SWE may be particularly well suited for treatment planning and endpoint assessment of MR‐guided FUS procedures because the same device used for therapy can be used as an excitation source for tissue stiffness quantification.
How do UK physiotherapists address weight loss among individuals with hip osteoarthritis? A mixed‐methods study
Authors: Holden Melanie Ann , Waterfield Jackie , Whittle Rebecca , Bennell Kim , Quicke Jonathan George , Chesterton Linda , Mallen Christian David 
Published: January 2019

AbstractBackgroundWeight loss is recommended as a core treatment for individuals with hip osteoarthritis who are overweight or obese. Physiotherapists play an important role in managing patients with hip osteoarthritis, but little is known about how they address weight. We aimed to explore how UK‐based physiotherapists currently address weight loss among individuals with hip OA.MethodsWe carried out a mixed‐methods study. A cross‐sectional questionnaire was mailed to 3,126 UK‐based musculoskeletal physiotherapists. Self‐reported approaches to addressing weight loss among individuals with hip osteoarthritis were explored using a case vignette and associated clinical management questions. Semi‐structured telephone interviews (n = 21) were completed with a purposeful sample of physiotherapists who returned the questionnaire and provided consent for further contact. Interview data were analysed thematically.ResultsThere was a 53% response rate to the questionnaires (n = 1,646), and 1,148 responders were eligible for analyses (based on having treated an individual with hip OA in the last 6 months). Eight‐five per cent of physiotherapists reported that they would address the vignette patient's weight, usually via advice (70%). Interviews identified that advice often focused on the importance of weight loss, with some physiotherapists offering basic advice on how to achieve weight loss. Multiple factors influenced their approach, including confidence, perceived remit and patient receptiveness.ConclusionsUK physiotherapists commonly address weight loss among patients with hip osteoarthritis, by offering advice relating to the importance of weight loss. However, provision of more specific guidance on how to achieve weight loss is variable. With additional training, physiotherapists could play an important role in supporting weight loss among patients with hip OA, thus potentially optimizing treatment outcomes.
Validation of in vivo MRS measures of metabolite concentrations in the human brain
Authors: Dhamala Elvisha , Abdelkefi Ines , Nguyen Mavesa , Hennessy T. Jay , Nadeau Hélène , Near Jamie 
Published: January 2019

PurposeIn vivo magnetic resonance spectroscopy (MRS) is the only technique capable of non‐invasively assessing metabolite concentrations in the brain. The lack of alternative methods makes validation of MRS measures challenging. The aim of this study is to assess the validity of MRS measures of human brain metabolite concentrations by comparing multiple MRS measures acquired using different MRS acquisition sequences.MethodsSingle‐voxel SPECIAL and MEGA‐PRESS MR spectra were acquired from both the dorsolateral prefrontal cortex and primary motor cortices in 15 healthy subjects. The SPECIAL spectrum, as well as both the edit‐off and difference spectra of MEGA‐PRESS were each analyzed in LCModel to obtain estimates of the absolute concentrations of total choline (TCh; glycerophosphocholine + phosphocholine), total creatine (TCr; creatine + phosphocreatine), N‐acetylaspartate (NAA), N‐acetylaspartylglutamate (NAAG), NAA + NAAG, glutamate (Glu), glutamine (Gln), Glu + Gln, scyllo‐inositol (Scyllo), myo‐inositol (Ins), glutathione (GSH), γ‐aminobutyric acid (GABA), lactate (Lac) and aspartate (Asp). Then, having obtained up to three independent measures of each metabolite per brain region per subject, correlations between the different measures were assessed.ResultsThe degree of correlation between measures varied greatly across both the metabolites and sequences tested. As expected, metabolites with the most prominent spectral peaks (TCh, TCr, NAA + NAAG, Ins and Glu) had the most well‐correlated measures between methods, while metabolites with less prominent spectral peaks (Lac, Gln, GABA, Asp, and NAAG) tended to have poorly‐correlated measures between methods. Some metabolites with relatively less prominent spectral peaks (GSH, Scyllo) had fairly well‐correlated measures between some methods. Combining metabolites improved the agreement between methods for measures of NAA + NAAG, but not for Glu + Gln.ConclusionsGiven that the ground truth for in vivo MRS measures is never known, the method proposed here provides a promising means to assess the validity of in vivo MRS measures, which has not yet been explored widely.
Hybrid enriched bidiagonalization for discrete ill‐posed problems
Authors: Hansen Per Christian , Dong Yiqiu , Abe Kuniyoshi 
Published: January 2019

SummaryThe regularizing properties of the Golub–Kahan bidiagonalization algorithm are powerful when the associated Krylov subspace captures the dominating components of the solution. In some applications the regularized solution can be further improved by enrichment, that is, by augmenting the Krylov subspace with a low‐dimensional subspace that represents specific prior information. Inspired by earlier work on GMRES, we demonstrate how to carry these ideas over to the bidiagonalization algorithm, and we describe how to incorporate Tikhonov regularization. This leads to a hybrid iterative method where the choice of regularization parameter in each iteration also provides a stopping rule.
Direct solution method for the equilibrium problem for elastic stents
Authors: Grubišić Luka , Tambača Josip 
Published: January 2019

SummaryWe are interested in numerical methods for approximating vector‐valued functions on a metric graph. As a model problem, we formulate and analyze a numerical method for the solution of the stationary problem for the one‐dimensional elastic stent model. The approximation is built using the mixed finite element method. The discretization matrix is a symmetric saddle‐point matrix, and we discuss sparse direct methods for the fast and robust solution of the associated equilibrium system. The convergence of the numerical method is proven and the error estimate is obtained. Numerical examples confirm the theoretical estimates.
Keeping College Options Open: A Field Experiment to Help all High School Seniors Through the College Application Process
Authors: Oreopoulos Philip , Ford Reuben 
Published: January 2019

AbstractRecent research suggests that the college application process itself prevents access. This paper reports results from a school‐based experiment in which application assistance is incorporated into the high school curriculum for all graduating seniors at low‐transition schools. Over three workshops, students were guided to pick programs of interest that they were eligible for, apply for real, and complete the financial aid application. The goal was to create a real college option for exiting students to make the transition easier and more salient. Among all graduating seniors, the program increased application rates by 15 percentage points, and college going rates by 5 percentage points. Among those not taking advanced‐level courses, college enrollment increased by 9 percentage points. The program generated significant effects for a wide range of heterogeneous groups, including both males and females, those from urban and rural schools, and those with above and below average grades. While more intensive than other tested approaches, in‐class application assistance may provide a more effective approach for bridging the gap towards higher education.
PROMIS pediatric measures validated in a longitudinal study design in pediatric oncology
Authors: Hinds Pamela S. , Wang Jichuan , Cheng Yao I. , Stern Emily , Waldron Mia , Gross Heather , DeWalt Darren A. , Jacobs Shana S. 
Published: January 2019

AbstractPurposeThis study assessed the responsiveness to change over time and theorized associations of Patient‐Reported Outcomes Measurement Information System (PROMIS) pediatric measures in children and adolescents in treatment for cancer to determine measure readiness for use in cancer clinical trials.MethodsWe administered eight PROMIS (three symptom, two psychological, and three performance) pediatric short‐form measures and the Symptom Distress Scale (SDS) to 96 pediatric oncology patients at three time points during a course of chemotherapy. We assessed responsiveness using paired t tests and generalized estimating equation (GEE) models, calculated standardized response mean (SRM) values for PROMIS measures, and examined scores over three data points (T1–T3). Guided by the theory of unpleasant symptoms (TOUS), we examined associations among the PROMIS measures, the SDS, and other variables using GEE.ResultsThe paired t tests showed statistically significant changes in two psychological measures and one performance measure from T1 to T2; three symptom, two psychological and two performance measures from T2 to T3; and three symptom and two psychological measures from T1 to T3. Findings from GEE models indicate PROMIS pediatric measures had statistically significant short‐term and long‐term changes, controlling for demographic and clinical variables. One performance measure did not achieve significant change at any time point. We found positive support for theorized relationships in the TOUS.ConclusionsMost of the PROMIS pediatric measures demonstrated changes over time and had significant relationships as theorized, thus supporting concurrent and construct validity of these measures when administered to pediatric oncology patients during a course of chemotherapy. This evidence supports the measures’ readiness for use in clinical trials.
Iminoimidazole‐based Co(II) and Fe(II) complexes: Syntheses, characterization, and catalytic behaviors for isoprene polymerization
Authors: Zhang Xianhui , Zhu Guangqian , Mahmood Qaiser , Zhao Mengmeng , Wang Liang , Jing Chuyang , Wang Xiaowu , Wang Qinggang 
Published: January 2019

ABSTRACTA stereoselectivity switchable polymerization of isoprene has been developed, which is catalyzed by iminoimidazole‐Co(II) and ‐Fe(II) complexes. The influence of substituents ranging from electron donating to the electron withdrawing on the iminoimidazole‐Co(II) and ‐Fe(II) catalysts is investigated for isoprene polymerization. Two sets of iminoimidazole‐Co(II) and ‐Fe(II) complexes have been prepared and fully characterized. X‐ray crystallography analysis reveals that the complexes Co1 and Fe1 adopt distorted tetrahedral geometries. In the presence of AlEt2Cl as co‐catalyst, all the Co(II) complexes are active and the catalytic activity is highly dependent on the molar ratio of Al/Co. All the Co(II) complexes exhibit higher activities at low Al/Co ratio. Compared with the Co(II) complexes, the Fe(II) complexes are essentially inactive under the identical condition. However, on activation with combination of AlEtCl2 and [Ph3C][B(C6F5)4], both Co(II) and Fe(II) complexes display high activities with good conversions of isoprene (up to >99%). Additionally, low molecular weight and high trans‐1,4‐unit (>96%) selectivity are characteristics of the resultant polyisoprene. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 767–775
Lung disease and vitamin D levels in cystic fibrosis infants and preschoolers
Authors: Oliveira Marina S. , Matsunaga Natasha Y. , Rodrigues Marina L. E. , Morcillo André M. , de Oliveira Ribeiro Maria A. G. , Ribeiro Antônio F. , de Fátima C. P. Servidoni Maria , Nogueira Roberto José N. , Pereira Monica Corso , Ribeiro José Dirceu , Toro Adyléia Aparecida D. C. 
Published: January 2019

AbstractIntroductionVitamin D acts on the immune system and lung response. Patients with cystic fibrosis (CF) may be deficient in this vitamin. The aims of the study were to evaluate vitamin D levels and severity of lung disease in infants and preschoolers diagnosed with CF, and to compare them to a group of children without pancreatic insufficiency (PI).MethodsPatients with CF up to 4 years old were included, and compared to an age‐matched group of children without diagnosis of CF. CF group had medical records and High Resolution Thorax Computed Tomography (HRCCT) evaluated in order to verify the severity of lung disease. Information on demographic data, sun exposure habits, supplemental vitamin D therapy, and on the season at the time of vitamin D sampling were collected for both groups.ResultsThis study included 45 patients in the CF group and 102 in the non‐CF group, with no differences in age (P = 0.327) between them. There was no association between vitamin D levels and markers of lung disease in the CF group. The non‐CF group had lower daily sun exposure (P = 0.034), and lower supplementation than the CF group (P < 0.001). Supplementation and seasonality were the determinant variables for vitamin D levels, which were lower for non‐supplemented children and for assessments during fall/winter.ConclusionThere was no association between lung disease severity and vitamin D levels in CF group. Supplementation and seasonality were associated to higher vitamin levels.
Phase 1 study of PSMA ADC, an antibody‐drug conjugate targeting prostate‐specific membrane antigen, in chemotherapy‐refractory prostate cancer
Authors: Petrylak Daniel P. , Kantoff Philip , Vogelzang Nicholas J. , Mega Anthony , Fleming Mark T. , Stephenson Joe J. , Frank Richard , Shore Neal D. , Dreicer Robert , McClay Edward F. , Berry William R. , Agarwal Manish , DiPippo Vincent A. , Rotshteyn Yakov , Stambler Nancy , Olson William C. , Morris Stephen A. , Israel Robert J. 
Published: January 2019

BackgroundProstate‐specific membrane antigen (PSMA) is a well‐characterized target that is overexpressed selectively on prostate cancer cells. PSMA antibody‐drug conjugate (ADC) is a fully human IgG1 monoclonal antibody conjugated to the microtubule disrupting agent monomethyl auristatin E (MMAE), which is designed to specifically bind PSMA‐positive cells, internalize, and then release its cytotoxic payload into the cells. PSMA ADC has demonstrated potent and selective antitumor activity in preclinical models of advanced prostate cancer. A Phase 1 study was conducted to assess the safety, pharmacokinetics, and preliminary antitumor effects of PSMA ADC in subjects with treatment‐refractory prostate cancer.MethodsIn this first‐in‐man dose‐escalation study, PSMA ADC was administered by intravenous infusion every three weeks to subjects with progressive metastatic castration‐resistant prostate cancer (mCRPC) who were previously treated with docetaxel chemotherapy. The primary endpoint was to establish a maximum tolerated dose (MTD). The study also examined the pharmacokinetics of the study drug, total antibody, and free MMAE. Antitumor effects were assessed by measuring changes in serum prostate‐specific antigen (PSA), circulating tumor cells (CTCs), and radiologic imaging.ResultsFifty‐two subjects were administered doses ranging from 0.4 to 2.8 mg/kg. Subjects had a median of two prior chemotherapy regimens and prior treatment with abiraterone and/or enzalutamide. Neutropenia and peripheral neuropathy were identified as important first‐cycle and late dose‐limiting toxicities, respectively. The dose of 2.5 mg/kg was determined to be the MTD. Pharmacokinetics were approximately dose‐proportional with minimal drug accumulation. Reductions in PSA and CTCs in subjects treated with doses of ≥1.8 mg/kg were durable and often concurrent.ConclusionsIn an extensively pretreated mCRPC population, PSMA ADC demonstrated acceptable toxicity. Antitumor activity was observed over dose ranges up to and including 2.5 mg/kg. The observed anti‐tumor activity supported further evaluation of this novel agent for the treatment of advanced metastatic prostate cancer.
Trap–treat–release: horizontal transfer of fipronil in field colonies of black carpenter ants, Camponotus pennsylvanicus
Authors: Buczkowski Grzegorz 
Published: January 2019

AbstractBACKGROUNDHorizontal insecticide transfer is thought to play an important role in controlling a wide range of urban pests including ants, bed bugs, cockroaches, and termites. Despite decades of research and numerous laboratory studies, horizontal transfer has never been demonstrated in the field. As a result, the importance of horizontal transfer (and the resulting secondary kill) for practical pest management remains unknown. The goal of this study was to provide the first experimental examination of horizontal transfer under field conditions. The specific objective was to investigate horizontal transfer of fipronil in field colonies of black carpenter ants, Camponotus pennsylvanicus.RESULTSLaboratory experiments demonstrated that fipronil is effectively transferred from treated donors to untreated recipients and causes significant secondary mortality. Fipronil was effectively vectored to untreated ants from donors exposed via residual and direct spray applications, and 100% mortality was achieved with both exposure routes. Furthermore, horizontal transfer continued beyond secondary mortality and resulted in significant tertiary mortality, which has not been previously demonstrated in ants. Field experiments utilized a novel, three‐step control method consisting of trap–treat–release and demonstrated that fipronil is effectively transferred when foraging workers are trapped, treated, and subsequently released back into their colonies.CONCLUSIONThe current study is the first field demonstration of the importance of horizontal transfer for the control of pest ants. The trap–treat–release method may be an effective alternative to broadcast spray applications and could help alleviate problems such as insecticide run‐off, environmental contamination, and non‐target effects. This method has the potential to provide effective management of invasive and pest ants and should be further tested across a wider range of ant species, habitats, and active ingredients. © 2019 Society of Chemical Industry