bluuebunny/crossref_metadata_2025_split huggingface dataset:
A VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF TOLFENAMIC ACID IN PRESENCE OF ITS PHARMACOPOEIAL IMPURITIES
Authors: FERNANDES ADISON , P. N. SANJAY PAI 
Published: September 2019

Objective: The proposed research work was conducted to develop a single reverse-phase high-performance chromatography (RP-HPLC) method capable of separating two Pharmacopoeial related impurities as well as degradation product of Tolfenamic acid (TA). The drug was subjected to various stress conditions recommended under ICH Q1A (R2) guidelines.
Methods: The desired separation of two Pharmacopoeial impurities and one degradant generated under oxidative stress was carried out using Sunfire ODS C-18 (250 x 4.6 mm, 5 µm) column maintained at 40 °C. Isocratic elution was carried out using acetonitrile and ammonium dihydrogen orthophosphate buffer (10 mmol, pH 2.5) in the ratio of 80:20 v/v. The detection was carried out at 205 nm using flow rate of 1 ml/min. The developed method was validated as per ICH Q2 (R1) guidelines for specificity, linearity, accuracy, precision, Limit of detection (LOD), Limit of Quantification (LOQ) and robustness.
Results: Linearity response of TA was found at a concentration range of 10-100µg/ml, with a correlation coefficient of 0.9987. The Pharmacopoeial impurity A and impurity B showed linearity results at concentration of 0.1-1µg/ml, with correlation coefficient of 0.9984 for Impurity A and 0.9989 for Impurity B. The % recovery during accuracy studies for TA and the two impurities were within the acceptance range of 95-105%. LOD and LOQ for TA were found to be 4.561µg/ml and 133.771µg/ml respectively. For impurity A, LOD and LOQ were found to be 0.035 µg/ml and 0.106 µg/ml and for Impurity B, LOD and LOQ were 0.042 µg/ml and 0.128 µg/ml. With slight variation of organic phase in mobile phase and flow rate the method exhibited good robustness. Under forced degradation studies the drug was found stable under hydrolytic, photolytic and thermal stress conditions, but was found susceptible for degradation under oxidative stress with appearance of a degradant peak. From on the RRT values of Pharmacopoeial impurities and the formed degradant it was inferred that the developed method is selective for the drug in the presence of impurities or degradants.
Conclusion: The developed stability-indicating method is found to be simple, rapid, accurate, precise and robust as compared to other proposed methods while determining TA in presence of its Pharmacopoeial impurities and degradation products. Hence the developed method can be used for analysis of stability samples of TA in presence of its related impurities.
Modeling of implementation of the new Organ Procurement and Transplantation Network/United Network for Organ Sharing policy for patients with hepatocellular carcinoma
Authors: Kokabi Nima , Nezami Nariman , Xing Minzhi , Ludwig Johannes M , Strazzabosco Mario , Kim Hyun S 
Published: September 2019

Aim:
To simulate effects of the new Organ Procurement and Transplantation Network/United Network for Organ Sharing policy on the patients’ characteristics and post orthotopic liver transplantation (OLT) outcome.
Materials & methods:
The United Network for Organ Sharing database was used to identify patients with hepatocellular carcinoma who were listed for OLT 2002–2014. All patients (actual group) versus simulated group with new 6-month delay in assigning Model for End-Stage Liver Disease score exception and Model for End-Stage Liver Disease exception cap of 34 were compared.
Results & conclusion:
With the new policy, 7,745 (30.4%) of the transplanted patients would have received a delayed transplantation or not be transplanted. The simulated group also showed significantly higher mean overall survival after OLT (p < 0.002) and received more locoreginal treatments (p < 0.001).
CONDIÇÕES BUCAIS DE PACIENTES CARDIOPATAS CRÔNICOS
Authors: Schütz Jasper Da Silva , Flores Manuela Furtado , Montenegro Márlon Munhoz , Furtado Mariana Vargas , Polanczyc Carisi Anne , Haas Alex Nogueira , Rösing Cassiano Kuchenbecker 
Published: September 2019

Objetivo: Descrever as condições de saúde bucal e hábitos comportamentais relacionados à saúde de indivíduos com doença arterial coronariana crônica (DAC) em acompanhamento em uma unidade de atendimento cardiológico do Hospital de Clínicas de Porto Alegre.
Materiais e Métodos: Foram avaliados 100 pacientes consecutivos que frequentaram a unidade entre junho de 2011 e março de 2012. Dados demográficos, socioeconômicos e comportamentais foram obtidos. Um exame bucal foi realizado avaliando os índices de placa visível (IPV) e sangramento gengival (ISG), recessão gengival (RG), profundidade de sondagem (PS), sangramento à sondagem (SS) e perda de inserção (PI), além do índice CPO-D.
Resultados: Observou-se um predomínio de indivíduos do gênero masculino, sendo que a faixa etária predominante foi a partir de 60 anos na amostra do estudo. Cerca de metade dos indivíduos era ex-fumante. Mais de três quartos da amostra relatou visitas ao dentista de maneira irregular. Os parâmetros relacionados ao biofilme supragengival apresentaram médias elevadas, contabilizando índices de placa e sangramento médios de cerca de 68% e 47%, respectivamente. Mais da metade dos dentes examinados possuíam PS ≥4 mm, e o sangramento subgengival (SS) esteve presente em aproximadamente três quartos dos sítios examinados. A maior parte dos dentes examinados apresentou PI ≥6 mm. Em média, os indivíduos do presente estudo apresentaram 13,2 dentes perdidos. O CPO-D médio encontrado foi de 10,9 dentes.
Conclusão: A presente amostra apresentou condições de saúde bucal compatíveis com a epidemiologia das doenças bucais mais prevalentes na população brasileira. Porém, esta condição é alarmante no contexto de saúde, uma vez que cada vez mais tem-se associado perda dentária e doenças periodontais a maiores riscos de eventos cardiovasculares.
Influência da técnica de proporcionamento pó/líquido e da fase de inclusão nas propriedades de uma resina acrílica ativada por micro-ondas
Authors: Rottini Juliana , Henriques Manuela De Borges , Portella Fernando Freitas , Fortes Carmen Beatriz Borges 
Published: September 2019

Objetivo: Avaliar a influência do método de proporcionamento pó/líquido e da fase de inclusão na microdureza Knoop, temperatura de transição vítrea, resistência ao impacto Izod, massa específica e grau de inchamento de uma resina acrílica ativada por micro-ondas.
Métodos: Uma resina acrílica do tipo 5 foi preparada utilizando duas formas de proporcionamento pó/líquido (proporção recomendada pelo fabricante e proporcionamento pela técnica da saturação) e incluída em diferentes fases (fase fibrilar e fase de massa). Para o proporcionamento conforme orientações do fabricante utilizou-se três partes de pó para cada parte de líquido. Na técnica da saturação o líquido foi gotejado sobre o pó até o completo umedecimento. As resinas polimerizadas foram caracterizadas quanto a microdureza Knoop, a temperatura de transição vítrea, a resistência ao impacto Izod, a massa específica e o grau de inchamento.
Resultados: A fase de inclusão não influenciou nenhuma das propriedades avaliadas (p>0,05), contudo os grupos em que o proporcionamento foi realizado utilizando-se a técnica da saturação apresentaram microdureza Knoop, temperatura de transição vítrea, resistência ao impacto Izod e massa específica superiores, e grau de inchamento inferior em comparação com os grupos proporcionados conforme orientação do fabricante (p
Prevalência de lesões bucais no serviço público de saúde do município de Passo Fundo – RS, Brasil
Authors: Rocha Gabriela Da , Felin Gabriela Caovilla , Bona Mayara Cristina De , Yépez Franklin David Gordillo , Conto Ferdinando De 
Published: September 2019

Resumo
O cirurgião-dentista ocupa uma posição estratégica no reconhecimento das alterações que envolvem a cavidade bucal e o diagnóstico precoce constitui uma das formas mais eficazes de combater uma doença. Objetivo: Esta pesquisa relatou a prevalência das patologias bucais que acometeram os pacientes que procuraram o Serviço de Prevenção e Diagnóstico Precoce de Câncer de Boca na rede Municipal de Saúde de Passo Fundo – RS entre janeiro de 2006 e dezembro de 2010. Materiais e Métodos: O estudo foi realizado por meio de análise dos prontuários de atendimento de todos os pacientes atendidos neste ambulatório. Foi feito um levantamento das lesões encontradas, associando os fatores de risco, gênero e idade visando determinar a prevalências dessas patologias. Resultados: O grupo das hiperplasias reacionais foi o mais prevalente com 31,3% dos casos. As lesões bucais acometem principalmente pacientes com mais de 40 anos. Conclusão: Pacientes do gênero masculino, com mais de 40 anos, que apresentam fatores de riscos associados, são o grupo mais propenso a desenvolver neoplasias malignas na cavidade bucal.
Atlantic meridional overturning circulation stable over the last 150 years
Authors: Parker Albert , Ollier Clifford 
Published: September 2019

Abstract
The Atlantic Meridional Overturning Circulation (AMOC) describes the northward flow of warm, salty water in the upper layers, and the southward flow of colder water in the deep Atlantic layers. AMOC strength estimates at 41°N latitude based on satellite sea surface height (SSH), and ARGO ocean temperature, salinity and velocity, and finally the difference in between the absolute mean sea levels (MSL) of the tide gauges of The Battery, New York, 40.7°N latitude, and Brest, 48.3°N latitude. Results suggest that the AMOC has been minimally reducing but with a positive acceleration since 2002, has been marginally increasing but with a negative acceleration since 1993, and has not been reducing but only oscillating with clear periodicities up 18 years, 27 years and about 60 years since 1856.
PRODUK UNGGULAN BERNILAI EKONOMIS BERBAHAN DASAR SAMPAH NON ORGANIK DALAM MENCEGAH KERUSAKAN LINGKUNGAN DESA KARANGANYAR KABUPATEN SUMENEP
Authors: Deshariyanto Dwi , Diana Anita Intan Nura , Wibisono Aryo 
Published: September 2019

Dalam rangka mengemplementasikan pengurangan sampah plastik, Pemerintah Kabupaten Sumenep dalam hal ini adalah Badan Lingkungan Hidup (BLH) mencanangkan untuk memberlakukan plastik berbayar kepada pelaku usaha seperti pusat perbelanjaan (Jar, 2016). Walaupun program pemerintah ini dapat mengurangi timbulan sampah yang semakin meningkat tiap tahunnya, tetapi butuh inovasi kreatif yang didominasi oleh masyarakat untuk mengurangi timbulan sampah serta meningkatkan perekonomian masyarakat setempat. Produk ekonomi kreatif ini akan mendukung program pemerintah tahun 2018 yaitu Visit Sumenep 2018. Menurut Kepala Disbudparpora Kabupaten Sumenep, pihaknya telah melakukan pemetaan terhadap beberapa lokasi wisata yang ada di Kabupaten Sumenep, contohnya pantai slopeng, yang berada di Kecamatan Dasuk. Tempat wisata yang dikelilingi oleh pohon kelapa dan gunung pasirnya akan menjadi kawasan mainan di laut. Pantai lombang yang dikenal pasir putihnya dan pohon cemara udangnya ini akan menjadi wisata alam. Pulau Gili Iyang yang kaya akan oksigen, mencapai 20,9 persen akan menjadi wisata kesehatan. Pulau Gili Labak di Kecamatan Talango yang terkenal dengan ekosistem lautnya, akan menjadi wisata alam dan kerajinan (News Madura, 2017). Walaupun pihak Disbudparpora hanya memetakan beberapa daerah saja sebagai kawasan wisata, kawasan lain yang berada disekeliling juga dapat memperlihatkan potensi yang dimiliki.
Hasil analisis baik secara kualitatif maupun kuantitatif yang dilakukan mulai tahap persiapan sampai tahap pelaksanaan, semuanya berjalan lancar. Warga Desa Karanganyar sangat antusias mengikuti seluruh rangkaian kegiatan sosialisasi dan pelatihan, hal ini dapat dilihat dari beberapa dokumentasi di bab sebelumnya. Secara kuantitatif pemahaman warga tentang kebersihan lingkungan, prosedur pembuatan miniatur kerapan sapi, dan prosedur pembuatan website secara garis besar ada peningkatan yang cukup signifikan, hal ini dapat dilihat pada hasil analisis yang dijelaskan pada bab sebelumnya baik berupa tabel rekapitulasi kuisioner pra dan pasca sosialisasi/pelatihan maupun pie chart. Adapun rencana selanjutnya yang akan dilaksanakan adalah monitoring dan pendampingan, publikasi media elektronik sebanyak mungkin, dan penyusunan laporan akhir.
PERENCANAAN TEBAL PERKERASAN JALAN SERGANG – JEMBATAN JENGKONG (NO. 243) KM 8 KEC. BATU PUTIH KABUPATEN SUMENEP
Authors: Suwandi Achmad , Jasuli Darma 
Published: September 2019

Jalan merupakan prasarana transportasi darat yang meliputi sebagian jalan, termasuk bangunan pelengkap dan pelengkapnya yang diperuntukkan bagi lalulintas, yang berada pada permukaan tanh, di atas permukaaan tanah, di bawah permukaan tanah dan/air, serta di atas permukaan air, kecuali jalan kereta api, dan jalan lori. Tamabang batu putih di desa batu putih merupakan salah satu sumber daya alam yang berada di kabupaten sumenep jalan sergang – jembatan jengkong (no. 243) km 8 kec. Batu putih kabupaten sumenep merupakan satu satunya jalan untuk atau akses tambang batu putih dan rusaknya jalan sangat mengganggu proses distribusi batu putih.
Perencanaan tebal perkerasan lentur dan biaya konstruksi perkerasan lentur pada jalan sergang – jembatan jengkong (No. 243) km 8 kec. Batu putih kabupaten sumenep dalam penyelesaiannya menggunakan penelitian kuantitatif. Proses pengumpulan datanya menggunakan dua jenis data yang pertama data primer yang meliputi data LHR dan yang kedua data sekunder meliputi kajian pustaka dan literatur. Dalam penelitian ini teknik analisis datanya menggunakan Microsoft office excel yang untuk menghitung rencana anggaran biaya dan autocad untuk menggambar. Untuk prosedur perhitungan disesuaikan dengan SNI -1732-1989.
Hasil survey Lalu Lintas Harian Rata-Rata (LHR) didapat jumlah kendaraan yang lewat keseluruhan yaitu 21164 smp. Jalan yang akan direncanakan panjang 3 km dan lebar jalan 4 m. Perhitungan tebal perkerasan dengan menggunakan laston AC-WC didapat tebal 2,50 cm dan yang akan direncanakan dengan tebal 4 cm. Rencana anggaran biaya (RAB) pada perencanaan jalan tersebut senilai Rp 2.613.171.000,00 (Dua milyar enam ratus tiga belas juta seratus yujuh puluh satu ribu rupiah).
METODE TANYA JAWAB MULTIARAH SEBAGAI UPAYA UNTUK MENINGKATKAN PRESTASI BELAJAR MATEMATIKA SISWA KELAS III SEMESTER II TAHUN PELAJARAN 2016/2017 SD NEGERI 4 TONJA
Authors: Luhrini Dyah Wuryaning 
Published: September 2019

<p>Penelitian ini dilaksanakan di SD Negeri 4 Tonja di Kelas III semester II tahun pelajaran 2016/2017 yang kemampuan siswanya dalam mata pelajaran Matematika masih rendah. Tujuan penulisan penelitian tindakan kelas ini adalah untuk mengetahui apakah metode tanya jawab multiarah dapat meningkatkan prestasi belajar siswa. Metode pengumpulan datanya adalah tes prestasi belajar. Metode analisis datanya adalah deskriptif. Hasil yang diperoleh dari penelitian ini adalah metode tanya jawab multiarah dapat meningkatkan prestasi belajar siswa. Ini terbukti dari hasil yang diperoleh pada awalnya 60,17, pada siklus I menjadi 69,30 dan pada siklus II menjadi 79,44. Kesimpulan yang diperoleh dari penelitian ini adalah penggunaan metode tanya jawab multiarah dapat meningkatkan prestasi belajar matematika siswa kelas III Semester II SD Negeri 4 Tonja Tahun Pelajaran 2016/2017 .</p>
KISAH DHRUVA SEBAGAI MEDIA PENDIDIKAN KARAKTER PADA ANAK
Authors: Lestari Ni Kadek Dwi 
Published: September 2019

This paper aims to describe the personality prominent of characteristics from Visnu Puraana of Dhruva story. the author describes many phenomena that indicate the decline of the morality of generations such as: elementary school children who have been smoking, teenagers who are exposed to free sex, lack of tolerance in social life, and there is a shift in values regarding norms of decency and ethics. Weak understanding of religious values can be regarded as an indicator of moral degradation. A civilization would want more improvement in regards to morality. In relation to the moral degradation of the nation's generation the government and society want children to have 18 national characteristics being; believe in religion, honesty, tolerance, fair for all, discipline, hardworking, creative, independent, democratic, curios to learn, national pride, communicative, peace-loving, avid readers, caring about the environment, social care, and responsibility. Building character using education for children is one way to make civilization better. The cultivation of character using education for children starts from an early age, ie through story or stories in Puraana that can be used as a medium of character building for children.
PENDIDIKAN HOLISTIK JIDDU KRISHNAMURTI
Authors: Yogiswari Krisna Sukma 
Published: September 2019

<p>Pendidikan merupakan cara yang strategis kaitannya dengan upaya individu mengembangkan potensinya. Strategi pembelajaran terus diperbaiki guna tercapainya cita-cita pendidikan itu sendiri. Pendidikan holistik yang menjadi fokus kajian para aktivis dan pemerhati pendidikan. Model pendidikan holistik menekankan pentingnya perilaku psikomotorik serta keaktifan yang menyeluruh. Pengembangan kemampuan kognitif yang menyangkut nilai-nilai akademis tetap dianggap penting meskipun bukan merupakan satu-satunya tujuan utama yang harus diasah. Filsafat Jiddu Krishnamurti yang mengajarkan humanisme juga menjadi pendukung dari pendidikan holistik. <strong> </strong></p>Kata Kunci: Pendidikan Holistik, Humanisme
Tirtayatra sebagai Bentuk Wisata Religi Masyarakat Hindu di Bali
Authors: Aryanatha I Nengah 
Published: September 2019

<p><em>Various forms of travel nowadays continue to grow, one of which is religious tourism. Religious tourism is one of the phenomenon that is currently starting to populate, it proved many activities or activities associated with religious tourism such as Tirta Yatra conducted by Hindu community in Bali. In some community groups, religious tourism is often used as a monthly, annual, and routine activities. In addition to getting the calm and pleasure (refreshing), it will also gain insight into the sacred historical sites and increase awareness of gratitude for the omnipotence of God (Ida Sang Hyang Widhi Wasa). Therefore, not only the health of mind that is obtained through religious tourism, but also the reward by interpreting the tour as a worship to improve or strengthen the faith.</em></p>
ANALISIS KUAT TEKAN, KUAT TARIK DAN SIFAT FISIS SEMEN ORGANIK TERBUAT DARI BAHAN LIMBAH DAUR ULANG
Authors: Syarif Muhammad 
Published: September 2019

Semen organik merupakan semen alternatif terbaru selain semen portland, dibuat dari mendaur ulang sampah organik, limbah batu bara berupa fly ash dan bottom ash serta mensubtitusi tanah mediteran dan tanah liat. Penelitian ini sebagai langkah kebijakan dalam penyelamatan lingkungan. Pengujian kuat tekan dan kuat tarik belah beton silinder menggunakan semen organik dan sebagai pembandingnya menggunakan semen portland melalui metode water curing dan dry curing pada umur 3,7,14,21 dan 28 hari. Hasil uji tekan beton menggunakan semen organik diperoleh 8,52 MPa pada metode water curing dan 14,52 MPa pada metode dry curing, sedang pada beton yang menggunakan semen portland yaitu 22,37 MPa pada metode water curing dan 19,71 MPa pada metode dry curing. Hasil uji kuat tarik belah menggunakan semen organik pada umur beton 28 hari mencapai 0,96 MPa pada metode water curing dan 1,22 MPa pada metode dry curing. Adapun yang menggunakan semen portland yaitu 2,03 MPa pada metode water curing dan 2,03 MPa pada metode dry curing. Hasil uji fisis berat jenis semen organik adalah 3,01 gr/ml sedang untuk semen portland adalah 3.16 gr/ml. Berat jenis semen organik 3,05 gr/ml dan berat jenis semen portland yaitu 3,15 gr/ml. Kehalusan butiran semen organik yang lolos pada ayakan 200 mesh sebanyak 56%, lebih halus dari semen portland yaitu 52%. Berat padat semen organik 1200 kg/m3 lebih ringan dari semen portland yang mencapai 1250 kg/m3. Waktu ikat awal semen organik adalah 105 menit dan waktu ikat akhir semen organik adalah ke 225. Untuk semen portland waktu ikat awalnya adalah 90 menit sedang waktu ikat akhirnya mencapai 180 menit.
The Importance And Development Of Remote Banking In Uzbekistan
Authors: Toshtemirovich Mamadiyarov Zokir 
Published: September 2019

In the implementation of remote control systems of the bank account used in the banking practice of the Republic of Uzbekistan, information flows are rapidly moving, the current state of remote banking services in the banking system of Uzbekistan, as well as measures for their wide use are being taken.
The article discusses the issues of improvement of remote banking services, the problems in it and the author's relationship on the development of remote banking services in commercial banks.
Financial (Il) Literacy And Stability Of The Financial System
Authors: Reddy Dr.  P. Srinivas 
Published: September 2019

The aim of the author of this paper is to show the relationship between the levels of financial
Literacy of individuals and company’s managers and the stability of financial markets, asset
Markets and the stability of the financial system as a whole. In post-conflict Bosnia and Herzegovina (BiH) economy was ''struck'' by foreign banks and financial capital that has swept the local public ''hungry'' for loans but also under-educated in the financial sense to borrow and use borrowed funds more effectively and accept tolerable burden of debt. Financial illiteracy and the willingness to accept the conditions imposed by banks have led to difficulties in servicing obligations and deteriorating loan portfolio of banks. In such circumstances, the onset of the financial crisis has brought something positive. The trend of rapid borrowing of citizens and companies in BiH was abruptly cut, but on the other hand problems with servicing the loan already taken simultaneously arose. The problems are still not dramatic but it should be noted that problems in the banking sector come to the surface only after one and a half to two years after the crisis. The author believes that a more serious approach to the financial literacy of citizens and managers and owners of small businesses is crucial, not only for the economy as a whole but also for the health of the banking system or financial system of the country.
“A Study on the Influence of Rewards on Job Satisfaction With Special Reference to Education Industry in Oman”
Authors: Sambamoorthy Mrs Nithya , Raman Mr Subhash Kodiyil , Thayyil Mr Bhraguram 
Published: September 2019

This research is an examination and a study on the influence of rewards on job satisfaction of lecturers at Shinas College of Technology (ShCT). In academic industry, rewards are one of the factors that affecting job satisfaction of the employees and this will lead to affect their performance in their jobs. So, when rewards are more the job satisfaction will be high and when rewards are less the job satisfaction will be less. On the other hand, the age will not affect the job satisfaction. Previous research reveals that Job satisfaction is very important to success the industry and the rewards are the main factors which affect job satisfaction. The main purpose of this study is to know the influence of rewards in job satisfaction among the lecturers in ShCT. Moreover, this research attempts to identify how much rewards affect the job satisfaction in ShCT. For this study used two types of data which are: primary data and secondary data. The sources of primary data is the response from lecturers at ShCT. It is collected through structured questionnaire and distributed such to 60 respondents. Secondary data, collected from internet, books, journals, articles etc.