bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mothers' challenges with the parental control of 3‐year‐old children in Japan: A qualitative study
Authors: Onishi Ryuta , Saeki Kazuko , Hirano Michiyo 
Published: April 2019

AbstractBackgroundParents often struggle against the negativism of 3‐year‐old children in exerting parental control. Although most research on parental control is from western cultures, Japanese mothers may face unique challenges because of their sociocultural background. We therefore explored mothers' challenges in exerting parental control over 3‐year‐old children in Japan.MethodsA descriptive qualitative approach was adopted. The participants were 10 Japanese mothers with children aged 3–4 years. We conducted individual semistructured interviews and analysed the data via qualitative content analysis.ResultsWe found four categories and a structure of the challenges mothers faced in exerting parental control. Mothers' control attempts had four main intentions, each with a different subject (i.e., the children, themselves, the family, and society). Most challenges with parental control stemmed from mothers' “consciousness of parental responsibility.” In confronting the child in their attempts to exert parental control, mothers perceived a “struggle with the child's negativism,” which led them to recognize that they could not find a correct method of discipline. Furthermore, in the face of conflicting roles, mothers experienced “confusion in seeking the righteous answer as a parent.” Some mothers began to feel that they were discovering their maternal role in their own way rather than finding a correct answer, which formed a “conviction that my own parenting is not incorrect.”ConclusionsThe challenges mothers faced in exerting parental control over their 3‐year‐old children served as a turning point for them to reflect on themselves as parents. However, due to societal monitoring of parents and mothers' multiple roles in the family, it can be difficult for mothers to fully overcome the challenges of parental control. It is necessary to foster social capital in the community to which the mother belongs and to create an atmosphere in which community members can watch over parents warmly.
Circular RNA DOCK1 promotes bladder carcinoma progression via modulating circDOCK1/hsa‐miR‐132‐3p/Sox5 signalling pathway
Authors: Liu Peihua , Li Xiaozhou , Guo Xi , Chen Jinbo , Li Chao , Chen Minfeng , Liu Longfei , Zhang Xiangyang , Zu Xiongbing 
Published: April 2019

AbstractObjectivesTo reveal the role of circular RNA (circRNA) DOCK1 (circDOCK1) as a potential biomarker and therapeutic target and its competing endogenous RNA mechanism in bladder carcinoma (BC).MethodsThe next‐generation sequencing (NGS) technology was introduced to screen the circRNA expression profiles of BC using microarray. qPCR and Western blots assay were employed to measure the gene expression in different groups. Cell counting kit‐8, EdU and transwell assays were applied to detect the cell viability, proliferation and migration potential, respectively. Luciferase reporter assay was used to test the binds between hsa‐miR‐132‐3p/Sox5. Xenografted tumour growth of nude mice was performed to test the role of circDOCK1 in vivo.ResultsCircDOCK1 was upregulated in BC tissues and cell lines. Repression of circDOCK1 reduced cell viability, inhibited cell proliferation and curbed the cell migration potential of BC cell. CircDOCK1 played its role via regulation of circDOCK1/hsa‐miR‐132‐3p/Sox5 pathway in BC cells. Suppression circDOCK1 inhibited the tumour growth in vivo.ConclusionIn this study, we revealed that circDOCK1 affected the progression of BC via modulation of circDOCK1/hsa‐miR‐132‐3p/Sox5 pathway both in vitro and in vivo and providing a potential biomarker and therapeutic targets for BC.
Outcomes in adults with cerebral palsy: systematic review using the International Classification of Functioning, Disability and Health
Authors: Benner Joyce L , Noten Suzie , Limsakul Chonnanid , Van Der Slot Wilma M A , Stam Henk J , Selb Melissa , Van Den Berg‐Emons Rita J G , Roebroeck Marij E 
Published: April 2019

AimIn the context of the development of an International Classification of Functioning, Disability and Health (ICF) Core Set for adults with cerebral palsy (CP), this systematic review sought to identify the outcome measures used in studies on adults with CP, to examine their content using the ICF as a reference, and to demonstrate the most studied areas in this population.MethodEmbase, MEDLINE, Web of Science, PsycINFO, CINAHL, Cochrane, and Google Scholar were searched for studies on adults with CP published between 2000 and 2017. Meaningful concepts of commonly used outcome measures were linked to the ICF, and frequencies of resultant ICF categories were explored.ResultsIn 274 included articles, 332 outcome measures were identified of which 155 were commonly used. In total, 4409 meaningful concepts were linked to the ICF. The component ‘Activities and participation’ included the most frequent categories, followed by ‘Body functions’. The most frequent categories were b280 ‘Sensation of pain’ (37.6%), d450 ‘Walking’ (33.3%), and d850 ‘Remunerative employment’ (27.5%).InterpretationThe broad range of ICF categories identified in this systematic review emphasizes the heterogeneity of functioning and disability in adults with CP. The current results specifically reflect the researchers’ perspective and will serve as candidate categories to consider in the development of an ICF Core Set for adults with CP.What this paper adds

Outcomes studied in adults with cerebral palsy are captured in varying International Classification of Functioning, Disability and Health (ICF) categories.

Activities and participation were studied more frequently than body functions and structures.

Mobility, employment, and self‐care were most frequent within ICF's ‘Activities and participation’ component.

Pain and neuromusculoskeletal and movement‐related functions were most frequent within ‘Body functions’.
Comparing postural instability and gait disorder and akinetic‐rigid subtyping of Parkinson disease and their stability over time
Authors: Erro R. , Picillo M. , Amboni M. , Savastano R. , Scannapieco S. , Cuoco S. , Santangelo G. , Vitale C. , Pellecchia M. T. , Barone P. 
Published: April 2019

Background and purposeParkinson disease (PD) patients are classically classified according to two alternative motor subtyping methods: (i) tremor‐dominant versus postural instability and gait disorder; (ii) tremor‐dominant versus akinetic‐rigid. The degree of overlap between the two classification systems at diagnosis of PD and their temporal stability, as well as the correspondence between the two systems, were examined over a follow‐up period of 4 years.MethodsNewly diagnosed, untreated PD patients were classified as tremor‐dominant versus postural instability and gait disorder and tremor‐dominant versus akinetic‐rigid at baseline and after 2 and 4 years.ResultsThere was a poor overlap between the two classification systems at any time point and baseline subtype status could not predict 4‐year subtype membership. In fact, about half of our cohort shifted category during the first 2 years, regardless of the classification scheme adopted. A lower rate of shift was observed from 2‐ to 4‐year follow‐up.ConclusionsThe two classical motor subtyping methods of PD poorly overlap, which implies that a patient can be categorized as tremor‐dominant in one classification system but not in the other. Moreover, their temporal instability undermines their prognostic value in the early stage of PD.
Parental Involvement and Adolescents’ Academic Achievement: Latent Profiles of Mother and Father Warmth as a Moderating Influence
Authors: Chung Gerard , Phillips Jonathan , Jensen Todd M. , Lanier Paul 
Published: April 2019

Parental involvement in their adolescents’ education plays an important role in promoting their children's academic outcomes. Yet, more research is needed to examine the relationship between parenting practices and parental warmth as well as to consider the potential joint contribution of warmth from both fathers and mothers. Thus, the primary purpose of the current study is to examine the extent to which patterns of parental warmth across fathers and mothers moderate the association between parental involvement and adolescents’ grade point average (GPA) and school engagement behaviors. Latent profile analysis was conducted to identify disparate profiles of fathers’ and mothers’ warmth within a nationally representative sample of 2,306 youths (51% male; mean age = 15.31 years, SD = 1.50; 77% non‐Hispanic White) residing in opposite‐sex, two‐parent families from Wave I and II of the National Longitudinal Study of Adolescent to Adult Health. Latent‐class enumeration processes support a five‐profile solution characterized by differences in levels of parental warmth and congruency across parents: (a) Congruent High Warmth, (b) Congruent Moderate Warmth, (c) Congruent Low Warmth, (d) Incongruent High Mother/Low Father Warmth, and (e) Incongruent Low Father/Lower Mother Warmth. Subsequent multiple linear regression analyses reveal a moderating effect for Congruent Low Warmth on the relationship between parental involvement and adolescents’ GPA. Ultimately, the results show that variation in parental warmth exists across fathers and mothers with differing impact on adolescents’ outcomes. Excluding one parent without considering the joint effects of both parents will not produce an accurate and precise understanding of parenting in research or practice.
Mania‐ and anxiety‐like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice
Authors: Bartsch Victoria B. , Lord Julia S. , Diering Graham H. , Zylka Mark J. 
Published: April 2019

AbstractGenome‐wide association studies linked diacylglycerol kinase eta and iota to mood disorders, including bipolar disorder and schizophrenia, and both genes are expressed throughout the brain. Here, we generated and behaviorally characterized female mice lacking Dgkh alone, Dgki alone, and double Dgkh/Dgki‐knockout (dKO) mice. We found that fewer than 30% of newborn pups raised by dKO females survived to weaning, while over 85% of pups survived to weaning when raised by wild‐type (WT) females. Poor survival under the care of dKO mothers was unrelated to pup genotype. Moreover, pups from dKO dams survived when fostered by WT dams, suggesting the poor survival rate of dKO‐raised litters was related to impaired maternal care by dKO dams. Nest building was similar between WT and dKO dams; however, some dKO females failed to retrieve any pups in a retrieval assay. Pups raised by dKO dams had smaller or absent milk spots and reduced weight, indicative of impaired nursing. Unlike WT females, postpartum dKO females showed erratic, panicked responses to cage disturbances. Virgin dKO females showed behavioral signs of anxiety and mania, which were not seen in mice lacking either Dgkh or Dgki alone. Our research indicates that combined deletion of Dgkh and Dgki impairs maternal behavior in the early postpartum period, and suggests female dKO mice model symptoms of mania and anxiety.
Photoageing‐related skin changes in different age groups: a clinical evaluation by biophysical and imaging techniques
Authors: Fossa Shirata M. M. , Alves G.A.D. , Maia Campos P.M.B.G. 
Published: April 2019

AbstractObjectivesIn view of the lack of studies about the morphological and structural changes caused by solar radiation in young people, the aim of the present study was to evaluate the photoageing‐related changes in the skin of different age groups by biophysical and imaging techniques.MethodsForty‐four healthy female subjects were divided into two age groups: Group 1 (G1): 18–35 years old and Group 2 (G2): 40–60 years old. The skin of malar region of the face was evaluated in terms of mechanical properties, disorder in the pigmentation pattern, morphological and structural changes using the Cutometer®, Colorimeter®, Visioface® and Dermascan C® devices and reflectance confocal microscopy (Vivascope®).ResultsThe results showed that the main changes in the skin of G1 were related to the pigmentation pattern, the papilla format and depletion of thin collagen fibres. These alterations were also observed in the skin of G2, but with more pronounced effects.ConclusionThe knowledge about the skin changes caused by photoageing obtained in this study is very important for the development of dermocosmetic products for more effective treatments particularly focused on this type of skin. Finally, objective characterization of photoageing showed the importance of photoprotective habits since the first years of life in order to retard the appearance of skin changes caused by solar radiation.
Management of deep caries and the exposed pulp
Authors: Bjørndal L , Simon S. , Tomson P. L. , Duncan H. F. 
Published: April 2019

AbstractCaries prevalence remains high throughout the world, with the burden of disease increasingly affecting older and socially disadvantaged groups in Western cultures. If left untreated, caries will advance through dentine stimulating pulpitis and eventually pulp infection and necrosis; however, if conservatively managed, pulpal recovery occurs even in deep carious lesions. Traditionally, deep caries management was destructive with nonselective (complete) removal of all carious dentine; however, the promotion of minimally invasive biologically based treatment strategies has been advocated for selective (partial) caries removal and a reduced risk of pulp exposure. Selective caries removal strategies can be one‐visit as indirect pulp treatment or two‐visit using a stepwise approach. Management strategies for the treatment of the cariously exposed pulp are also shifting with avoidance of pulpectomy and the re‐emergence of vital pulp treatment (VPT) techniques such as partial and complete pulpotomy. These changes stem from an improved understanding of the pulp–dentine complex's defensive and reparative response to irritation, with harnessing the release of bioactive dentine matrix components and careful handling of the damaged tissue considered critical. Notably, the development of new pulp capping materials such as mineral trioxide aggregate, which although not an ideal material, has resulted in more predictable treatments from both a histological and a clinical perspective. Unfortunately, the changes in management are only supported by relatively weak evidence with case series, cohort studies and preliminary studies containing low patient numbers forming the bulk of the evidence. As a result, critical questions related to the superiority of one caries removal technique over another, the best pulp capping biomaterial or whether pulp exposure is a negative prognostic factor remain unanswered. There is an urgent need to promote minimally invasive treatment strategies in Operative Dentistry and Endodontology; however, the development of accurate diagnostic tools, evidence‐based management strategies and education in management of the exposed pulp are critical in the future.
Shrimp processing residue as an alternative ingredient for new product development
Authors: Gonçalves Alex Augusto , dos Santos Josué 
Published: April 2019

SummaryShrimp residues were dried (65 °C), grounded, and posteriorly used as an ingredient to the production of ‘spiced shrimp flour’ and ‘shrimp flavoured biscuits’. Both products were packed in modified atmosphere (100% N2) and stored for 180 days (25 °C) for shelf life evaluation. The centesimal composition, physicochemical, microbiological and sensory analyses were carried out in triplicate. The microbiological analysis (residue and shrimp flour) was within the limits of the legislation, confirming the hygienic–sanitary care during processing. The protein content was the most outstanding (40.13% for the spiced shrimp flour and 20.52% for the shrimp flavoured biscuits). The microbiological evaluation for the ‘spiced shrimp flour’ and ‘shrimp flavoured biscuits’ was below the legal limit, and both products were accepted by sensory analysis. The shelf life evaluation demonstrated stability for 6 months. Thus, we concluded that the Litopenaeus vannamei shrimp residue is a promising ingredient in the food industry.
Impact of low volume citrate tubes on results of first‐line hemostasis testing
Authors: Salvagno Gian Luca , Demonte Davide , Poli Giovanni , Favaloro Emmanuel J. , Lippi Giuseppe 
Published: April 2019

AbstractIntroductionPediatric tubes are increasingly used for drawing blood for hemostasis testing. This study has investigated the potential impact of low volume citrate tubes on results of first‐line hemostasis testing.MethodsThe study population comprised 34 patients on warfarin therapy and 17 ostensibly healthy volunteers. Blood was collected into five different evacuated blood tubes from each subject. On right arm, blood was drawn directly into two standard evacuated blood tubes (3‐mL Vacuette and 2‐mL Vacutest) and one evacuated low volume blood tube (1‐mL Vacuette) by straight needle venipuncture. On left arm, blood was drawn using a 5‐mL syringe and then transferred within two nonevacuated microtubes (0.5 mL MiniCollect and 0.5 mL Micro Test). Prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen were assayed on ACL TOP 700.ResultsSpearman's correlation of PT, APTT, and fibrinogen values obtained using different tubes was always satisfactory (ie, ≥0.93). A statistically significant bias was frequently found by comparing values obtained in different tubes. Nevertheless, the minimum quality specifications for bias were exceeded only by comparing data of Vacuette 1 mL with those of all other blood tubes for PT, by comparing data of Micro Test 0.5 mL with those of all other blood tubes for APTT, and by comparing data of Micro Test 0.5‐mL blood tubes with those of Vacuette 3 mL and Vacuette 1.ConclusionFirst‐line hemostasis testing using low volume citrate tubes may display differences sometimes exceeding the minimum quality specifications.
Evaluation of a rapid and automated heparin‐induced thrombocytopenia immunoassay
Authors: Refaai Majed A. , Conley Grace , Ortel Thomas L. , Francis John L. 
Published: April 2019

AbstractIntroductionHeparin‐induced thrombocytopenia (HIT) is a potentially life‐threatening adverse reaction of heparin. Laboratory evaluation of HIT is often not available within a reasonable time. We evaluated the HemosIL® HIT‐Ab(PF4‐H) (Instrumentation Laboratory), a rapid, on‐demand, fully automated, latex immunoturbidimetric assay (LIA).Materials and methodsFollowing determination of the LIA's reference interval and cutoff values, a multicenter study was conducted between March 2013 and June 2015. Plasma samples of HIT‐suspected patients (n = 632) were collected and evaluated by LIA on the ACL TOP® Family systems (Instrumentation Laboratory), enzyme‐linked immunosorbent assays (EIA), and serotonin release assay (SRA). Patient characteristics, medical conditions, comorbidities, laboratory results, and medications were collected via medical chart review. The pretest clinical probability of HIT was also calculated for each patient.ResultsBased on the 95% reference interval for healthy donors and HIT‐negative patients, a LIA value ≥1.0 U/mL was interpreted positive. The overall agreement of LIA versus EIA and SRA results were 90% (95% CI 88%‐92%) and 79% (95% CI 75%‐82%), respectively. The negative predictive value for LIA and EIA was comparable (87%) with SRA. The positive and negative percent agreements with the clinical probability were 89% (95% CI 69%‐97%) and 86% (95% CI 83%‐89%), respectively, with a negative predictive value of 99.6% (95% CI 98%‐100%).DiscussionOverall, the LIA results were comparable to those of EIA and SRA. This fully automated assay with a remarkable short analytical turnaround time of <20 minutes can be performed on‐demand, which would greatly facilitate more prompt management of HIT.
Effects of free‐air CO2 enrichment and drought on root growth of field grown maize and sorghum
Authors: Paeßens Benedikt , Manderscheid Remy , Pacholski Andreas , Varga Balazs , Erbs Martin , Kage Henning , Sieling Klaus , Weigel Hans‐Joachim 
Published: April 2019

AbstractIncreasing CO2 concentration ([CO2]) is thought to induce climate change and thereby increase air temperatures and the risk of drought stress, the latter impairing crop growth. The objective of this study was to investigate the effects of elevated [CO2] and drought stress on root growth of one maize genotype (Zea mays cv. Simao) and two sorghum genotypes (Sorghum bicolor cv. Bulldozer and Sorghum bicolor × Sorghum sudanense cv. Inka) under the cool moderate climate of Central Europe. It was hypothesized that root growth stimulation due to elevated [CO2] compensates for a reduced root growth under drought stress. Therefore, we established an experiment within a free‐air carbon dioxide enrichment system (FACE) in 2010 and 2011. Sorghum and maize genotypes were grown under ambient [CO2] (385 ppm CO2) and elevated [CO2] (600 ppm CO2) and in combination with restricted and sufficient water supply. Elevated [CO2] decreased root length density (RLD) in the upper soil layers for all genotypes, but increased it in deeper layers. Higher [CO2] enhanced specific root length (SRL) of “Simao” and “Bulldozer,” however, did not affect that of “Inka.” “Simao” achieved a higher SRL than the sorghum genotypes, indicating an efficient investment in root dry matter. Although elevated [CO2] affected the root growth, no interaction with the water treatment and, consequently, no compensatory effect of elevated [CO2] could be identified.
Healthcare practitioners' views and experiences of barriers and facilitators to weight management interventions for adults with intellectual disabilities
Authors: Doherty Alison J. , Jones Stephanie P. , Chauhan Umesh , Gibson Josephine M. E. 
Published: April 2019

AbstractBackgroundObesity is common in adults with intellectual disabilities, yet little is known about how weight management interventions are provided for this population.MethodsSemi‐structured interviews were held with 14 healthcare practitioners involved in weight management interventions in an English county. A study topic guide was developed to elicit practitioners' views and experiences of barriers and facilitators to weight management for adults with intellectual disabilities. Responses were analysed using thematic analysis.ResultsSeveral barriers are involved in weight management for people with intellectual disabilities including communication challenges, general practitioners' lack of knowledge and awareness of weight management services, inconsistencies in caring support, resource constraints, wider external circumstances surrounding the individuals and motivational issues. Facilitators include reasonable adjustments to existing weight management services. However, there is a need for specialist weight management provision for people with intellectual disabilities.ConclusionsThis study provides suggestions for future research, policy and practice consideration.