bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular line study of the S-type AGB star W Aquilae
Authors: Brunner M. , Danilovich T. , Ramstedt S. , Marti-Vidal I. , De Beck E. , Vlemmings W. H. T. , Lindqvist M. , Kerschbaum F. 
Published: June 2018

Context. With the outstanding spatial resolution and sensitivity of the Atacama Large Millimeter/sub-millimeter Array (ALMA), molecular gas other than the abundant CO can be observed and resolved in circumstellar envelopes (CSEs) around evolved stars, such as the binary S-type asymptotic giant branch (AGB) star W Aquilae.
Aims. We aim to constrain the chemical composition of the CSE and determine the radial abundance distribution, the photospheric peak abundance, and isotopic ratios of a selection of chemically important molecular species in the innermost CSE of W Aql. The derived parameters are put into the context of the chemical evolution of AGB stars and are compared with theoretical models.
Methods. We employ one-dimensional radiative transfer modeling – with the accelerated lambda iteration (ALI) radiative transfer code–of the radial abundance distribution of a total of five molecular species (CS, SiS, 30SiS, 29SiO and H13CN) and determine the best fitting model parameters based on high-resolution ALMA observations as well as archival single-dish observations. The additional advantage of the spatially resolved ALMA observations is that we can directly constrain the radial profile of the observed line transitions from the observations.
Results. We derive abundances and e-folding radii for CS, SiS, 30SiS, 29SiO and H13CN and compare them to previous studies, which are based only on unresolved single-dish spectra. Our results are in line with previous results and are more accurate due to resolution of the emission regions.
Disentangling hadronic from leptonic emission in the composite SNR G326.3−1.8
Authors: Devin J. , Acero F. , Ballet J. , Schmid J. 
Published: June 2018

Context. G326.3−1.8 (also known as MSH 15−56) has been detected in radio as middle-aged composite supernova remnant (SNR) consisting of an SNR shell and a pulsar wind nebula (PWN) that has been crushed by the SNR reverse shock. Previous γ-ray studies of SNR G326.3−1.8 revealed bright and extended emission with uncertain origin. Understanding the nature of the γ-ray emission allows probing the population of high-energy particles (leptons or hadrons), but can be challenging for sources of small angular extent.
Aims. With the recent Fermi Large Area Telescope data release Pass 8, which provides increased acceptance and angular resolution, we investigate the morphology of this SNR to disentangle the PWN from the SNR contribution. In particular, we take advantage of the new possibility to filter events based on their angular reconstruction quality.
Methods. We performed a morphological and spectral analysis from 300 MeV to 300 GeV. We used the reconstructed events with the best angular resolution (PSF3 event type) to separately investigate the PWN and the SNR emissions, which is crucial to accurately determine the spectral properties of G326.3−1.8 and understand its nature.
Results. The centroid of the γ-ray emission evolves with energy and is spatially coincident with the radio PWN at high energies (E > 3 GeV). The morphological analysis reveals that a model considering two contributions from the SNR and the PWN reproduces the γ-ray data better than a single-component model. The associated spectral analysis using power laws shows two distinct spectral features, a softer spectrum for the remnant (Γ = 2.17 ± 0.06) and a harder spectrum for the PWN (Γ = 1.79 ± 0.12), consistent with hadronic and leptonic origin for the SNR and the PWN, respectively. Focusing on the SNR spectrum, we use one-zone models to derive some physical properties, and we find in particular, that the emission is best explained with a hadronic scenario in which the high target density is provided by radiative shocks in H I clouds struck by the SNR.
A unified accretion-ejection paradigm for black hole X-ray binaries
Authors: Marcel G. , Ferreira J. , Petrucci P.-O. , Belmont R. , Malzac J. , Clavel M. , Henri G. , Coriat M. , Corbel S. , Rodriguez J. , Loh A. , Chakravorty S. 
Published: June 2018

Context. It has been suggested that the cycles of activity of X-ray binaries (XRB) are triggered by a switch in the dominant disk torque responsible for accretion. As the disk accretion rate increases, the disk innermost regions therefore change from a jet-emitting disk (JED) to a standard accretion disk (SAD).
Aims. While JEDs have been proven to successfully reproduce X-ray binary hard states, the existence of an outer cold SAD introduces an extra nonlocal cooling term. We investigate the thermal structure and associated spectra of such a hybrid disk configuration.
Methods. We use a two-temperature plasma code, allowing for outside-in computation of the disk local thermal equilibrium with self-consistent advection and optically thin-to-thick transitions in both radiation and gas supported regimes. The nonlocal inverse Compton cooling introduced by the external soft photons is computed by the BELM code.
Results. This additional cooling term has a profound influence on JED solutions, allowing a smooth temperature transition from the outer SAD to the inner JED. We explore the full parameter space in disk accretion rate and transition radius, and show that the whole domain in X-ray luminosities and hardness ratios covered by standard XRB cycles is well reproduced by such hybrid disk configurations. Precisely, a reasonable combination of these parameters allows us to reproduce the 3–200 keV spectra of each of five canonical XRB states. Along with these X-ray signatures, JED-SAD configurations also naturally account for the radio emission whenever it is observed.
Conclusions. By varying only the radial transition radius and the accretion rate, hybrid disk configurations combining an inner JED and an outer SAD are able to simultaneously reproduce the X-ray spectral states and radio emission of X-ray binaries during their outburst. Adjusting these two parameters, it is then possible to reproduce a full cycle. This will be shown in a forthcoming paper.
Palmar lokalisierter HPV16-positiver Morbus Bowen
Authors: Troyanova-Slavkova S. , Eickenscheidt L. , Aust D. , Gradistanac T. , Kowalzick L. 
Published: June 2018

ZusammenfassungDer Morbus Bowen ist ein In-situ-Plattenepithelkarzinom der Haut und ist klinisch charakterisiert durch solitäre, rote oder braun-rote, scharf oder unregelmäßig begrenzte, gering erhabene Papeln und Plaques mit schuppiger Oberfläche. Diese können entweder durch UV-bedingte Sonnenschäden − meist in lichtbelichteten Bereichen bei älteren Personen − oder durch humane Papillomavirus-Infektion − meist im anogenitalen Bereich junger Erwachsener − verursacht werden. Es wurden Fälle beschrieben, bei denen HPV in Genitalläsionen und an Tumoren der Finger gleichzeitig nachgewiesen werden konnten, was durch einen genital-digitalen Infektionsweg erklärt werden könnte. Wir beschreiben den Fall eines 49-jährigen Mannes mit einem HPV16-positiven Morbus Bowen an der Handinnenfläche. Weder bei unserem Patient noch bei seiner Partnerin waren andere Warzen, v. a. Genitalwarzen oder Genitaltumoren bekannt und konnten auch bei der klinischen Untersuchung des Patienten nicht nachgewiesen werden. Gleichwohl kann eine Übertragung durch Kontakt mit einer Hochrisiko-HPV-infizierten Person nicht ausgeschlossen werden.
Pharmacodynamic Effects of a 6-Hour Regimen of Enoxaparin in Patients Undergoing Primary Percutaneous Coronary Intervention (PENNY PCI Study)
Authors: Sumaya Wael , Parker William , Fretwell Rebekah , Hall Ian , Barmby David , Richardson James , Iqbal Javaid , Adam Zulfiquar , Morgan Kenneth , Gunn Julian , Mason Annah , Judge Heather , Gale Christopher , Ajjan Ramzi , Storey Robert 
Published: June 2018

AbstractDelayed onset of action of oral P2Y12 inhibitors in ST-elevation myocardial infarction (STEMI) patients may increase the risk of acute stent thrombosis. Available parenteral anti-thrombotic strategies, to deal with this issue, are limited by added cost and increased risk of bleeding. We investigated the pharmacodynamic effects of a novel regimen of enoxaparin in STEMI patients undergoing primary percutaneous coronary intervention (PPCI). Twenty patients were recruited to receive 0.75 mg/kg bolus of enoxaparin (pre-PPCI) followed by infusion of enoxaparin 0.75 mg/kg/6 h. At four time points (pre-anti-coagulation, end of PPCI, 2–3 hours into infusion and at the end of infusion), anti-Xa levels were determined using chromogenic assays, fibrin clots were assessed by turbidimetric analysis and platelet P2Y12 inhibition was determined by VerifyNow P2Y12 assay. Clinical outcomes were determined 14 hours after enoxaparin initiation. Nineteen of 20 patients completed the enoxaparin regimen; one patient, who developed no-reflow phenomenon, was switched to tirofiban after the enoxaparin bolus. All received ticagrelor 180 mg before angiography. Mean (± standard error of the mean) anti-Xa levels were sustained during enoxaparin infusion (1.17 ± 0.06 IU/mL at the end of PPCI and 1.003 ± 0.06 IU/mL at 6 hours), resulting in prolonged fibrin clot lag time and increased lysis potential. Onset of platelet P2Y12 inhibition was delayed in opiate-treated patients. No patients had thrombotic or bleeding complications. In conclusion, enoxaparin 0.75 mg/kg bolus followed by 0.75 mg/kg/6 h provides sustained anti-Xa levels in PPCI patients. This may protect from acute stent thrombosis in opiate-treated PPCI patients who frequently have delayed onset of oral P2Y12 inhibition.
Antikörpertitration bei der hämolytischen Erkrankung des Fetus und Neugeborenen – State of the Art
Authors: Flommersfeld Sabine , Ertl Birgit 
Published: June 2018

ZusammenfassungErgebnisse der immunhämatologischen Diagnostik stehen nicht immer in Einklang mit der klinischen Situation. Insbesondere bei der fetomaternalen Inkompatibilität, die zur hämolytischen Erkrankung des Fetus und Neugeborenen führen kann, ist eine Risikoabschätzung wichtig, um unnötige invasive Maßnahmen zu vermeiden. Hier hat sich die Antikörpertitration nach Antikörperspezifizierung durchgesetzt. Zu Methodik, Qualitätskontrollen und Interpretation gibt es keine differenzierten Handlungsempfehlungen in der Hämotherapie-Richtlinie der Bundesärztekammer. Wir stellen daher unsere Methodik vor und diskutieren die Vor- und Nachteile.
On the Formation of Modern Chinese Pseudo-Possessive-Object Constructions
Authors: Long Haiping 
Published: June 2018

Abstract
Modern Chinese Pseudo-Possessive-Object Constructions (shortened as Modern Chinese PPO constructions; e.g. ta shuo le wo de haohua (他说了我的好话) ‘he has put in a good word for me’ and ta chi le wo de doufu (他吃了我的豆腐) ‘he has taken advantage of me’) are actually constructions displaying possessor-affectee syncretism. They derive from Early Modern Chinese Real-Possessive-Object constructions in bridging contexts, some examples being wo ye quande liewei daren de jiu (我也劝得列位大人的酒), ‘I also urged all the magistrates here to finish drinking your wine’ and shi nage zai jie wo de duan li (是那个在揭我的短哩) ‘who is uncovering my demerits’. Di-transitive constructions in Middle Chinese and Early Modern Chinese (e.g. Changxing! quan er yibei jiu (长星，劝尔一杯酒) ‘Comet! I urge you (to finish drinking) a cup of wine’ and shuru gan jie wu duanchu (竖儒敢揭吾短处) ‘how dare the Confucius scholar uncover my demerits’) have provided structural templates for the formation of Modern Chinese PPO constructions. They also have led to a condition in which there are more examples of a maleficiary Modern Chinese PPO construction than examples of a beneficiary Modern Chinese PPO construction (e.g. ta chi le wo de doufu (他吃了我的豆腐) ‘he has taken advantage of me’ vs. ta shuo le wo de haohua (他说了我的好话) ‘he has put in a good word for me’). The grammaticalization pathway can also explain the formation of other constructions including another Modern Chinese PPO construction (e.g. ta chi le wo de kui (他吃了我的亏) ‘he has suffered the loss caused by me’), a Modern Chinese pseudo-object construction (e.g. wo ganxie ni de haoxin (我感谢你的好心) ‘I thank you for your kindness’), and a Modern Chinese pseudo-modifier construction (e.g. wo pa le yi xiawu de shan (我爬了一下午的山) ‘I did mountain-climbing for the whole afternoon’).
From #[Je]F suis Charlie to #JeSuisCharlie
Authors: Hamlaoui Fatima , Roussarie Laurent 
Published: June 2018

AbstractJe suis Charliewas used over 619.000 times in the two days that have followed the attack ofCharlie Hebdoand has regularly been taken up in both written and spoken forms since. A number of variants of this meme (i.e.Nous sommes tous (des) Charlie) have also emerged among French speakers. We argue that this is primarily related to the fact that the structure ofJe suis Charlieactually clashes with its meaning. Whereas its word order and default rightmost sentence stress are compatible either with an all-focus reading or a narrow focusing ofCharlie, the solidarity/empathy message it communicates suggests that its subject is narrowly focused. We propose that two strategies have emerged to solve this conflict: (i) various alternative forms have appeared that allow proper subject focusing and (ii) speakers have reinterpreted the original structure so as to pragmatically retrieve the (additive) focused nature of the subject.
Kato square root problem with unbounded leading coefficients
Authors: Escauriaza Luis , Hofmann Steve 
Published: June 2018

We prove the Kato conjecture for elliptic operators,

L
=
−
∇
⋅

(
(

A

+

D

)
∇

)

L=-\nabla \cdot \left ((\mathbf A+\mathbf D)\nabla \ \right )

, with

A

\mathbf A

a complex measurable bounded coercive matrix and

D

\mathbf D

a measurable real-valued skew-symmetric matrix in

R

n

\mathbb {R}^n

with entries in

B
M
O
(

R

n

)

BMO(\mathbb {R}^n)

; i.e., the domain of

L

\sqrt {L}\,

is the Sobolev space

H
˙

1

(

R

n

)

\dot H^1(\mathbb {R}^n)

in any dimension, with the estimate

‖

L

f

‖
2

≲
‖
∇
f

‖
2

\|\sqrt {L}\, f\|_2 \lesssim \| \nabla f\|_2

.
Doing science in difficult socioeconomic circumstances
Authors: Karasmanis Eva P. 
Published: June 2018

Doing scientific research can be a challenging, but creative and rewarding career. However, the challenge of doing research is orders of magnitude more difficult for scientists lacking access to the necessary resources. Resource-scarce environments are quite common worldwide and are highly contingent on the financial and social climate of one’s location. Through the experiences of four scientists, this Perspective explores the challenges associated with doing research in disadvantaged socioeconomic circumstances. By reflecting on the humble beginnings of these scientists, we examine the motivation to stay in or leave one’s home country, and how hardships can be leveraged to cultivate passionate and productive researchers.
Review of applications of high-throughput sequencing in personalized medicine: barriers and facilitators of future progress in research and clinical application
Authors: Lightbody Gaye , Haberland Valeriia , Browne Fiona , Taggart Laura , Zheng Huiru , Parkes Eileen , Blayney Jaine K 
Published: June 2018

Abstract
There has been an exponential growth in the performance and output of sequencing technologies (omics data) with full genome sequencing now producing gigabases of reads on a daily basis. These data may hold the promise of personalized medicine, leading to routinely available sequencing tests that can guide patient treatment decisions. In the era of high-throughput sequencing (HTS), computational considerations, data governance and clinical translation are the greatest rate-limiting steps. To ensure that the analysis, management and interpretation of such extensive omics data is exploited to its full potential, key factors, including sample sourcing, technology selection and computational expertise and resources, need to be considered, leading to an integrated set of high-performance tools and systems. This article provides an up-to-date overview of the evolution of HTS and the accompanying tools, infrastructure and data management approaches that are emerging in this space, which, if used within in a multidisciplinary context, may ultimately facilitate the development of personalized medicine.
ImmunomeBrowser: a tool to aggregate and visualize complex and heterogeneous epitopes in reference proteins
Authors: Dhanda Sandeep Kumar , Vita Randi , Ha Brendan , Grifoni Alba , Peters Bjoern , Sette Alessandro 
Published: June 2018

Abstract

Motivation
Datasets that are derived from different studies (e.g. MHC ligand elution, MHC binding, B/T cell epitope screening etc.) often vary in terms of experimental approaches, sizes of peptides tested, including partial and or nested overlapping peptides and in the number of donors tested.

Results
We present a customized application of the Immune Epitope Database’s ImmunomeBrowser tool, which can be used to effectively aggregate and visualize heterogeneous immunological data. User provided peptide sets and associated response data is mapped to a user-provided protein reference sequence. The output consists of tables and figures representing the aggregated data represented by a Response Frequency score and associated estimated confidence interval. This allows the user to visualizing regions associated with dominant responses and their boundaries. The results are presented both as a user interactive javascript based web interface and a tabular format in a selected reference sequence.

Availability and implementation
The ‘ImmunomeBrowser’ has been a longstanding feature of the IEDB (http://www.iedb.org). The present application extends the use of this tool to work with user-provided datasets, rather than the output of IEDB queries. This new server version of the ImmunomeBrowser is freely accessible at http://tools.iedb.org/immunomebrowser/.
Partitioned time-stepping scheme for an MHD system with temperature-dependent coefficients
Authors: Ravindran S S 
Published: June 2018

Abstract
In this paper, a partitioned time-stepping scheme for transient electromagnetically and thermally driven flow is analysed. The flow is modeled by coupled evolutionary magneto-hydrodynamic (MHD) equations with temperature-dependent coefficients. The partitioned scheme requires solving only one uncoupled MHD equation and one heat transfer equation per time step. It is based on Crank–Nicolson discretization in time and extrapolated treatment of the coupling and nonlinear terms such that skew-symmetry properties of the nonlinear terms are preserved. We prove that the proposed time-stepping scheme is unconditionally stable and derive error estimates for the fully discretized scheme using finite element spatial discretization in suitable norms. Numerical examples are presented that illustrate the accuracy and efficiency of the scheme.
The harmonic virtual element method: stabilization and exponential convergence for the Laplace problem on polygonal domains
Authors: Chernov Alexey , Mascotto Lorenzo 
Published: June 2018

AbstractWe introduce the harmonic virtual element method (VEM) (harmonic VEM), a modification of the VEM (Beirão da Veiga et al. (2013) Basic principles of virtual element methods. Math. Models Methods Appl. Sci., 23, 199–214.) for the approximation of the two-dimensional Laplace equation using polygonal meshes. The main difference between the harmonic VEM and the VEM is that in the former method only boundary degrees of freedom are employed. Such degrees of freedom suffice for the construction of a proper energy projector on (piecewise harmonic) polynomial spaces. The harmonic VEM can also be regarded as an ‘$H^1$-conformisation’ of the Trefftz discontinuous Galerkin-finite element method (TDG-FEM) (Hiptmair et al. (2014) Approximation by harmonic polynomials in starshaped domains and exponential convergence of Trefftz hp-DGFEM. ESAIM Math. Model. Numer. Anal., 48, 727–752.). We address the stabilization of the proposed method and develop an hp version of harmonic VEM for the Laplace equation on polygonal domains. As in TDG-FEM, the asymptotic convergence rate of harmonic VEM is exponential and reaches order $\mathscr{O}(\exp (-b\sqrt [2]{N}))$, where $N$ is the number of degrees of freedom. This result overperforms its counterparts in the framework of hp FEM (Schwab, C. (1998)p- and hp-Finite Element Methods: Theory and Applications in Solid and Fluid Mechanics. Clarendon Press Oxford.) and hp VEM (Beirão da Veiga et al. (2018) Exponential convergence of the hp virtual element method with corner singularity. Numer. Math., 138, 581–613.), where the asymptotic rate of convergence is of order $\mathscr{O}(\exp(-b\sqrt [3]{N}))$.
Contractions of Representations and Algebraic Families of Harish-Chandra Modules
Authors: Bernstein Joseph , Higson Nigel , Subag Eyal 
Published: June 2018

Abstract
We examine from an algebraic point of view some families of unitary group representations that arise in mathematical physics and are associated to contraction families of Lie groups. The contraction families of groups relate different real forms of a reductive group and are continuously parametrized, but the unitary representations are defined over a parameter subspace that includes both discrete and continuous parts. Both finite- and infinite-dimensional representations can occur, even within the same family. We shall study the simplest nontrivial examples and use the concepts of algebraic families of Harish-Chandra pairs and Harish-Chandra modules, introduced in a previous paper, together with the Jantzen filtration, to construct these families of unitary representations algebraically.
Algebraic Families of Harish-Chandra Pairs
Authors: Bernstein Joseph , Higson Nigel , Subag Eyal 
Published: June 2018

Abstract
Mathematical physicists have studied degenerations of Lie groups and their representations, which they call contractions. In this paper we study these contractions, and also other families, within the framework of algebraic families of Harish-Chandra modules. We construct a family that incorporates both a real reductive group and its compact form, separate parts of which have been studied individually as contractions. We give a complete classification of generically irreducible families of Harish-Chandra modules in the case of the family associated to $SL(2,\mathbb{R})$.
Information Criterion for Nonparametric Model-Assisted Survey Estimators
Authors: James Addison , Xue Lan , Lesser Virginia 
Published: June 2018

AbstractNonparametric model-assisted estimators have been proposed to improve estimates of finite population parameters. Flexible nonparametric models provide more reliable estimators when a parametric model is misspecified. In this article, we propose an information criterion to select appropriate auxiliary variables to use in an additive model-assisted method. We approximate the additive nonparametric components using polynomial splines and extend the Bayesian Information Criterion (BIC) for finite populations. By removing irrelevant auxiliary variables, our method reduces model complexity and decreases estimator variance. We establish that the proposed BIC is asymptotically consistent in selecting the important explanatory variables when the true model is additive without interactions, a result supported by our numerical study. Our proposed method is easier to implement and better justified theoretically than the existing method proposed in the literature.