bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maloclusión pseudoclase III en la dentición decidua resolución con aparato progénico
Authors: Porcel T. 
Published: February 2019

Pseudo Class III malocclusion is a functional imbalance that generally results from premature occlusal contacts that causes a functional anterior displacement of the mandible. These cases, if not treated at an early stage of development, may interfere in normal growth of bone bases, resulting in facial deformity. This paper suggests the selection of an adequate appliance considering the available possibilities for early intervention of Class III malocclusion. The use of the progenic appliance in such dental malocclusion allows correction in a few months and therapeutic stability mesio-positioned mandible encouraging favorable skeletal growth in a child of 5.6 years of age who came to the Postgraduate Clinic of the Latin American Institute of Dental Research and Education (ILAPEO) in Curitiba, Brazil. [ABSTRACT FROM AUTHOR]
Resumen (español):La maloclusión pseudoclase III es caracterizada por un desequilibrio funcional que, por lo general, resulta de contactos oclusales prematuros que causan un desplazamiento funcional anterior de la mandíbula. Estos casos, si no son tratados en una etapa inicial de desarrollo, pueden generar interferencias en el crecimiento normal de las bases óseas y resultar en una deformidad facial. Este papel conlleva a la selección de un aparato apropiado, tomando cuenta opciones actuales, para una intervención temprana en el desarrollo de maloclusiones de clase III. El uso del aparato progénico en este tipo de maloclusión, permite la corrección dental en pocos meses y una estabilidad terapéutica de la mandíbula mesio-posicionada fomentando un crecimiento esquelético favorable en una niña de 5,6 años de edad que acude a la clínica de postgrado del Instituto Latino Americano de Investigación y Enseñanza Odontológica (ILAPEO) en Curitiba, Brasil. [ABSTRACT FROM AUTHOR]
Evaluación del aprendizaje de los estudiantes de las carreras de medicina y odontología dentro de un modelo de atención interdisciplinario a nivel hospitalario, Centro Hospitalario Pereira Rossell, Montevideo Uruguay
Authors: Hermida Bruno María Laura 
Published: February 2019

Evaluation of the learning process of medicine and dentistry students within an assistential interdisciplinary teaching model at a hospital level, Hospital Center Pereira Rossell, Montevideo Uruguay
A CAD System for the Early Detection of Lung Nodules Using Computed Tomography Scan Images
Authors: Amer Hanan M. , Abou-Chadi Fatma E. , Kishk Sherif S. , Obayya Marwa I. 
Published: February 2019

In this paper, a computer-aided detection system is developed to detect lung nodules at an early stage using Computed Tomography (CT) scan images where lung nodules are one of the most important indicators to predict lung cancer. The developed system consists of four stages. First, the raw Computed Tomography lung images were preprocessed to enhance the image contrast and eliminate noise. Second, an automatic segmentation procedure for human's lung and pulmonary nodule canddates (nodules, blood vessels) using a two-level thresholding technique and morphological operations. Third, a feature fusion technique that fuses four feature extraction techniques: the statistical features of first and second order, value histogram features, histogram of oriented gradients features, and texture features of gray level co-occurrence matrix based on wavelet coefficients was utilised to extract the main features. The fourth stage is the classifier. Three classifiers were used and their performance was compared in order to obtain the highest classification accuracy. These are; multi-layer feed-forward neural network, radial basis function neural network and support vector machine. The performance of the proposed system was assessed using three quantitative parameters. These are: the classification accuracy rate, the sensitivity and the specificity. Forty standard computed tomography images containing 320 regions of interest obtained from an early lung cancer action project association were used to test and evaluate the developed system. The images consists of 40 computed tomography scan images. The results have shown that the fused features vector resulting from genetic algorithm as a feature selection technique and the support vector machine classifier give the highest classification accuracy rate, sensitivity and specificity values of 99.6%, 100% and 99.2%, respectively.
Sostdc1 Regulates NK Cell Maturation and Cytotoxicity
Authors: Millan Alberto J. , Elizaldi Sonny R. , Lee Eric M. , Aceves Jeffrey O. , Murugesh Deepa , Loots Gabriela G. , Manilay Jennifer O. 
Published: February 2019

AbstractNK cells are innate-like lymphocytes that eliminate virally infected and cancerous cells, but the mechanisms that control NK cell development and cytotoxicity are incompletely understood. We identified roles for sclerostin domain–containing-1 (Sostdc1) in NK cell development and function. Sostdc1-knockout (Sostdc1−/−) mice display a progressive accumulation of transitional NK cells (tNKs) (CD27+CD11b+) with age, indicating a partial developmental block. The NK cell Ly49 repertoire in Sostdc1−/− mice is also changed. Lower frequencies of Sostdc1−/− splenic tNKs express inhibitory Ly49G2 receptors, but higher frequencies express activating Ly49H and Ly49D receptors. However, the frequencies of Ly49I+, G2+, H+, and D+ populations were universally decreased at the most mature (CD27−CD11b+) stage. We hypothesized that the Ly49 repertoire in Sostdc1−/− mice would correlate with NK killing ability and observed that Sostdc1−/− NK cells are hyporesponsive against MHC class I–deficient cell targets in vitro and in vivo, despite higher CD107a surface levels and similar IFN-γ expression to controls. Consistent with Sostdc1’s known role in Wnt signaling regulation, Tcf7 and Lef1 levels were higher in Sostdc1−/− NK cells. Expression of the NK development gene Id2 was decreased in Sostdc1−/− immature NK and tNK cells, but Eomes and Tbx21 expression was unaffected. Reciprocal bone marrow transplant experiments showed that Sostdc1 regulates NK cell maturation and expression of Ly49 receptors in a cell-extrinsic fashion from both nonhematopoietic and hematopoietic sources. Taken together, these data support a role for Sostdc1 in the regulation of NK cell maturation and cytotoxicity, and identify potential NK cell niches.
Novel deleterious sequence change in the NLRP12 gene in a child with autoinflammatory syndrome, joint hypermobility and cutis laxa from India.
Authors: Ghosh Kanjaksha , Mishra Kanchan , Shah Avani , Patel Parizad , Shetty Shrimati 
Published: February 2019

An otherwise healthy male child of 9 years presented with paroxysmal fever and diffuse abdominal pain along with loss of appetite and nausea lasting for 3-4days every 4-6 weeks for last 2 years. He also has stretchable skin and hypermobile joint which he inherited from his mother who never suffered any paroxysmal attack of the kind. Work up for acute intermittent porphyria, lead poisoning and familial mediterranean fever was negative. A novel harmful sequence change in NLRP12 gene was detected and a diagnosis of NLRP12 associated autoinflammatory syndrome was made. This sequence change with disease has not yet been reported in the literature and is the first such case of NLRP12 related autoinflammatory syndrome from India.
H1N1 INFECTION IN PREGNANCY; A RETROSPECTIVE STUDY OF FETO-MATERNAL OUTCOME AND IMPACT OF THE TIMING OF ANTIVIRAL THERAPY
Authors: Al-Husban Naser 
Published: February 2019

Background and Objective: H1N1 infection carries an increased risk in pregnancy. Our aim was to study the fetomaternal outcome and the effect of early initiation of therapy.
Methods: This is a retrospective descriptive study. Confirmed infected cases were included. Maternal age, parity, gestational age at diagnosis, presenting symptoms, time between presentation and starting therapy, ICU admission, and maternal and perinatal outcome were evaluated.
Results: Nineteen confirmed patients were included. Most patients are 31 years old or more. Multiparous patients were 73.68% and 57.89% were in the third trimester. Most of our patients presented with cough, fever, and chills. Two patients were admitted to the ICU. One of them was a case of maternal mortality. 42.10% of patients were started on therapy only one day after clinical onset of symptoms. 26.31% delivered before 37 completed weeks. 73.68% delivered beyond term. Around one third delivered vaginally. 45% of babies weighed more than 3 kg. Four babies weighed less than 2 kg. Ninety percent had APGAR scores more than 8 at 1 and 5 minutes after delivery. Twenty five percent were admitted to the NICU with no neonatal mortalities.
Conclusions: H1N1 influenza A infection in pregnancy is associated with adverse maternal and perinatal outcomes. Medical and public awareness, low threshold for testing suspected pregnant patients, very early initiation of antiviral therapy, and multidisciplinary approach in our series decreased the overall adverse effects of this infection.
Experiences of student nurses regarding the bursary system in KwaZulu-Natal province, South Africa
Authors: Jacobs Eve , Scrooby Belinda , Du Preez Antoinette 
Published: February 2019

Background: During 2010, the South African nursing education system was restructured, changing student nurses from having supernumerary status to being bursary holders. Changes with the introduction of this new bursary system included institutional factors and benefits that could be removed from the students, potentially hampering students’ sense of belonging.Aim: This study aimed to describe the experiences of students receiving bursaries in KwaZulu-Natal (KZN) province and to make recommendations for improving the system to bursary providers, educational institutions and practical settings based on these students’ experiences of the bursary system.Setting: The experiences of student nurses regarding the bursary system are described within a specified setting comprising two nursing campuses in KZN.Method: A qualitative study design was used and seven focus group interviews were conducted with purposively selected participants, representing the target population of first-, second- and third-year male and female nursing students registered for the Diploma in Nursing (General, Psychiatric, Community) and Midwifery.Results: Two main themes and eight subthemes were identified. The findings indicated that some of the bursary system’s experiences were negative as opposed to students having supernumerary status. These experiences had negative socio-economic, psychological, clinical, academic and family impacts. Many concerns related to staff members’ attitudes, shortages of nurses and service demands during students’ clinical practice assignments.Conclusions: The bursary system was not viewed as being beneficial to students as they did not receive all the benefits from being bursary holders. Support in clinical and academic areas was lacking as they were considered to be employees during their clinical assignments. There is an urgent need to review the bursary system.
Thou shalt not smoke: Content and context in the Lord’s Resistance Army’s concept of the Ten Commandments
Authors: Holter Knut 
Published: February 2019

With the Ten Commandments as a case, the overall focus of this article is how a reader’s a priori concept of a text influences how he or she allows textual content and interpretive context to interact. The frame of the article is the claim by the so-called Lord’s Resistance Army (LRA) in Uganda that they will establish a society built on the Ten Commandments, a claim that raises questions about what they mean with this reference to ‘Ten Commandments’. The article falls into two parts. The first part surveys some examples from the history of interpretation of the Ten Commandments, demonstrating contextual and terminological fluidity both in their biblical versions and in their postbiblical history of interpretation. With this insight, the second part discusses how LRA refers to the Ten Commandments in ways that demonstrate that the very concept ‘Ten Commandments’ is stronger than the details of their content. This enables the LRA to form ‘new commandments’ fitting with their ideology and struggle.
Effectiveness of bendamustine in relapsed or refractory lymphoma cases: a Turkish Oncology Group study
Authors: Karadurmus Nuri , Paydas Semra , Esin Ece , Surmeli Zeki Gokhan , Yildiz Birol , Erturk Ismail , Nayir Erdinc , Dogan Mutlu , Sumbul Ahmet Taner , Barista Ibrahim , Gurkan Emel , Ocal Ramazan , Ferhanoglu Burhan , Ozgur Gokhan , Karakas Yusuf , Lacin Sahin , Ozaydin Sukru , Petekkaya Halil Ibrahim , Uskent Necdet 
Published: February 2019

IntroductionWe aimed to investigate the efficacy and side effects of bendamustine in relapsed/refractory lymphoma patients in Turkey. Material and methodsIn this retrospective study, we included relapsed/refractory Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) patients who underwent multiple lines of chemotherapy. The primary endpoint was to determine the objective response and toxicity.ResultsNinety-nine patients with a median age of 59.8 years were included in the study. Eighty-one patients had NHL (follicular lymphoma: 10, diffuse large B-cell lymphoma: 27, mantle-cell lymphoma: 18, marginal zone lymphoma: 9, small lymphocytic lymphoma/chronic lymphocytic leukemia: 17) and 18 patients had HL. The patients had previously received a median of three lines of chemotherapy (range: 2–8) except autologous stem cell transplantation (ASCT); 19 patients (HL: 11, NHL: 8) had undergone ASCT. The objective response rate (ORR) was 74.3%, the complete response rate was 57% (= 53), and the partial response rate was 16.6% ( = 19). The overall survival (OS) rate at 1 year was 74.6%. The progression-free survival (PFS) rate at 1 year was 62.5%. The most common side effects were lymphopenia, anemia and neutropenia. Side effects which were observed as grade 3 and higher levels were lymphopenia (14.1%), neutropenia (10.1%) and fatigue (7.1%). ConclusionsObjective response rate of bendamustine was found to be 74.3% in relapsed/refractory HL and NHL patients. It appears to be an effective option as a salvage treatment for patients who have previously received multiple lines of therapy.
SER-PD – Polish adaptation of the My Emotions Scale for the assessment of parents’ emotional reactions to child’s crying
Authors: Kaźmierczak Maria , Pawlicka Paulina 
Published: February 2019

BackgroundThe Polish adaptation of the My Emotions Scale measuring parental self-reported emotional reactions to a child’s crying is pre-sented. The scale measures parent-oriented (amusement, anxiety, frustration) and infant-oriented (sympathy and empathy) emo-tional reactions to a child’s crying, which has been defined as the most obvious early attachment behaviour.Participants and procedureA total of 495 parents of small children (including 376 mothers, no couples) took part in the study. Females were M = 27.79 (SD = 5.01) years old on average, whereas mean age of men was M = 31.71 (SD = 5.37) years. The majority of participants (74.90%) had one child. The average age of the assessed child was M = 9.17 months (SD = 4.43). Reliability and validity prop-erties of the scale are presented.ResultsThe results confirmed the five-factor model, which showed adequate fit indices. The SER-PD has adequate internal consistency. The criterion-related validity of the scale was established by correlating five dimensions of parental emotional reactions to the child’s crying with measures of dispositional empathy and contextually neutral emotional reactions.ConclusionsThe SER-PD gives the opportunity for broader analyses of the parental responsiveness construct. It is a useful tool to examine parent-child interactions easily and noninvasively, in large samples, and in situations where qualitative data might be difficult to obtain.
Assessing the construct validity and reliability of the Academic Motivation Scale in the Vietnamese context
Authors: Nguyen Quang Ngoc , Nguyen Luot Van 
Published: February 2019

BackgroundAcademic motivation is one of the most studied constructs in psychology. However, in Vietnam, the lack of valid and reliable instruments evaluating academic motivation has led to limitations in research on this topic. The Academic Motivation Scale (AMS) is widely applied to different contexts across the world. The purpose of the study is to assess the construct validity and reliability of the AMS with a sample of Vietnamese university students.Participants and procedureThe research study was conducted with a convenience sample of 341 university students. Male students accounted for 11.70% of participants. The average age was 20.28 with a standard deviation of 1.12. To participate in the study, students conducted an online questionnaire consisting of the AMS. We conducted confirmatory factor analysis (CFA) and correlation analysis and calculated Cronbach’s α to examine the validity and reliability of the scale.ResultsCFA indicated that the seven-factor model fitted the data best, with all the unstandardized factor loadings being statistically sig-nificant. Regarding reliability, AMS subscales had satisfactory Cronbach αs. Correlation analysis supported almost entirely the hypothesis about simplex structure of the AMS.ConclusionsConsidering the results, we suggest that the AMS has met the requirements for validity and reliability, and could be used in research with Vietnamese university students on academic motivation itself and its relationships with other psychological con-structs.
Assessment and comparison of radiation dose and image quality
in multi-detector CT scanners in non-contrast head and neck examinations
Authors: Khoramian Daryoush , Sistani Soroush , Firouzjah Razzagh Abedi 
Published: February 2019

PurposeTo assess and compare radiation dose and image quality from non-contrast head and neck computed tomo­graphy (CT) examinations from four different multi-detector CT (MDCT) scanners.Material and methodsFour CT scanners with different numbers of detector rows including one 4-MDCT, a 6-MDCT, a 16-MDCT, and a 64-MDCT were investigated. Common CT dose descriptors including volumetric CT dose index (CTDIv), dose length product (DLP), and the effective dose (ED), and image quality parameters include image noise, uniformity, and spatial resolution (SR) were estimated for each CT scanner with standard tools and methods. To have a precise comparison between CT scanners and related doses and image quality parameters, the ImPACT Q-factor was used.ResultsMinimum and maximum CTDIv, DLP, and ED in the head scan were 18 ± 3 and 49 ± 4 mGy, 242 ± 28 and 692 ± 173 mGy × cm, 0.46 ± 0.4 and 1.31 ± 0.33 mSv for 16-MDCT and 64-MDCT, respectively. And 16 ± 2 to 27 ± 3, 286 ± 127 to 645 ± 79 and 1.46 ± 0.65 to 3.29 ± 0.40 for neck scan, respectively. The Q-factor in head scan was 2.4, 3.3, 4.4 and 5.6 for 4-MDCT, 6-MDCT, 16-MDCT and 64-MDCT, respectively. The Q-factor in neck scan was 3.4, 4.6, 4.7 and 6.0 for 4-MDCT, 6-MDCT, 16-MDCT and 64-MDCT, respectively.ConclusionsThe results clearly indicate an increasing trend in the Q-factor from 4-MDCT to 64-MDCT units in both head and neck examinations. This increasing trend is due to a better SR and less noise of images taken and/or fewer doses in 64-MDCT.
Hypertrophic olivary degeneration in a 16-year-old girl after subtotal surgery of a brainstem pilocytic astrocytoma – a case report
Authors: Sobieraj Paulina , Duczkowski Marek , Terczyńska Iwona , Duczkowska Agnieszka , Krupa Katarzyna , Krupska Ewa , Bekiesińska-Figatowska Monika 
Published: February 2019

PurposeHypertrophic olivary degeneration (HOD) is a unique neurological condition caused by interruption of the dentato-rubro-olivary pathway, also known as the triangle of Guillain and Mollaret. Magnetic resonance (MR) imaging is the best modality to diagnose both the degeneration of the inferior olivary nucleus and the underlying cause.Case reportWe describe a case of a unilateral HOD in a 16-year-old girl several months after a subtotal excision of a brainstem pilocytic astrocytoma. Taking into account the patient’s history, tumour recurrence must have been considered, but the typical location and MR morphology, as well as the time of occurrence after brainstem surgery, contributed to the diagnosis of HOD. The causative factor was the interruption of the central tegmental tract, which forms one arm of the Guillain and Mollaret triangle. Additionally, this is an interesting case of a child, who stayed in a coma for several months following brainstem surgery, but finally was discharged home with only minor neurological defects and returned to normal life.ConclusionsHypertrophic olivary degeneration is an infrequent neurological condition, especially in the paediatric population. Nevertheless, it should be considered when interpreting late postoperative scans of children with a history of a brain tumour.
Evaluation of various patient-, lesion-, and procedure-related factors on the occurrence of pneumothorax as a complication of CT-guided percutaneous transthoracic needle biopsy
Authors: Shiekh Yassar , Haseeb Wani A. , Feroz Imza , Shaheen Feroze A. , Gojwari Tariq A. , Choh Naseer A. 
Published: February 2019

PurposeTo assess the influence of various patient-, lesion-, and procedure-related variables on the occurrence of pneumothorax as a complication of CT-guided percutaneous transthoracic needle biopsy.Material and methodsIn a total of 208 patients, 215 lung/mediastinal lesions (seven patients were biopsied twice) were sampled under CT guidance using coaxial biopsy set via percutaneous transthoracic approach. Incidence of post procedure pneumothorax was seen and the influence of various patient-, lesion-, and procedure-related variables on the frequency of pneumothorax with special emphasis on procedural factors like dwell time and needle-pleural angle was analysed.ResultsPneumothorax occurred in 25.12% (54/215) of patients. Increased incidence of pneumothorax had a statistically significant correlation with age of the patient (p = 0.0020), size (p = 0.0044) and depth (p = 0.0001) of the lesion, and needle-pleural angle (p = 0.0200). Gender of the patient (p = 0.7761), emphysema (p = 0.2724), site of the lesion (p = 0.9320), needle gauge (p = 0.7250), patient position (p = 0.9839), and dwell time (p = 0.9330) had no significant impact on the pneumothorax rate.ConclusionsThis study demonstrated a significant effect of the age of the patient, size and depth of the lesion, and needle-pleural angle on the incidence of post-procedural pneumothorax. Emphysema as such had no effect on pneumothorax rate, but once pneumothorax occurred, emphysematous patients were more likely to be symptomatic, necessitating chest tube placement. Gender of the patient, site of the lesion, patient position during the procedure, and dwell time had no statistically significant relation with the frequency of post-procedural pneumothorax. Surprisingly, needle gauge had no significant effect on pneumothorax frequency, but due to the small sample size, non-randomisation, and bias in needle size selection as per lesion size, further studies are required to fully elucidate the causal relationship between needle size and post-procedural pneumothorax rate. The needle should be as perpendicular as possible to the pleura (needle-pleural angle close to 90°), to minimise the possibility of pneumothorax after percutaneous transthoracic needle biopsy.