bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detailed study of the Milky Way globular cluster Laevens 3
Authors: Longeard Nicolas , Martin Nicolas , Ibata Rodrigo A , Collins Michelle L M , Laevens Benjamin P M , Bell Eric , Mackey Dougal 
Published: September 2019

ABSTRACT
We present a photometric and spectroscopic study of the Milky Way satellite Laevens 3. Using MegaCam/Canada–France–Hawaii Telescope $g$ and $i$ photometry and Keck II/DEIMOS multi-object spectroscopy, we refine the structural and stellar properties of the system. The Laevens 3 colour–magnitude diagram shows that it is quite metal-poor, old ($13.0 \pm 1.0$ Gyr), and at a distance of $61.4 \pm 1.0$ kpc, partly based on two RR Lyrae stars. The system is faint ($M_V = -2.8^{+0.2}_{-0.3}$ mag) and compact ($r_h = 11.4 \pm 1.0$ pc). From the spectroscopy, we constrain the systemic metallicity (${\rm [Fe/H]}_\mathrm{spectro} = -1.8 \pm 0.1$ dex) but the metallicity and velocity dispersions are both unresolved. Using Gaia DR2, we infer a mean proper motion of $(\mu _\alpha ^*,\mu _\delta)=(0.51 \pm 0.28,-0.83 \pm 0.27)$ mas yr−1, which, combined with the system’s radial velocity ($\langle v_r\rangle = -70.2 \pm 0.5 {\rm \, km \,\, s^{-1}}$), translates into a halo orbit with a pericenter and apocenter of $40.7 ^{+5.6}_{-14.7}$ and $85.6^{+17.2}_{-5.9}$ kpc, respectively. Overall, Laevens 3 shares the typical properties of the Milky Way’s outer halo globular clusters. Furthermore, we find that this system shows signs of mass segregation that strengthens our conclusion that Laevens 3 is a globular cluster.
Effects of magnetic fields on the location of the evaporation valley for low-mass exoplanets
Authors: Owen James E , Adams Fred C 
Published: September 2019

ABSTRACT
The observed distribution of radii for exoplanets shows a bimodal form that can be explained by mass-loss from planetary atmospheres due to high-energy radiation emitted by their host stars. The location of the minimum of this radius distribution depends on the mass–radius relation, which in turn depends on the composition of planetary cores. Current studies suggest that super-Earth and mini-Neptune planets have iron-rich and hence largely Earth-like composition cores. This paper explores how non-zero planetary magnetic fields can decrease the expected mass-loss rates from these planets. These lower mass-loss rates, in turn, affect the location of the minimum of the radius distribution and the inferred chemical composition of the planetary cores.
Resting-State SEEG May Help Localize Epileptogenic Brain Regions
Authors: Goodale Sarah E , González Hernán F J , Johnson Graham W , Gupta Kanupriya , Rodriguez William J , Shults Robert , Rogers Baxter P , Rolston John D , Dawant Benoit M , Morgan Victoria L , Englot Dario J 
Published: September 2019

Abstract

BACKGROUND
Stereotactic electroencephalography (SEEG) is a minimally invasive neurosurgical method to localize epileptogenic brain regions in epilepsy but requires days in the hospital with interventions to trigger several seizures.

OBJECTIVE
To make initial progress in the development of network analysis methods to identify epileptogenic brain regions using brief, resting-state SEEG data segments, without requiring seizure recordings.

METHODS
In a cohort of 15 adult focal epilepsy patients undergoing SEEG, we evaluated functional connectivity (alpha-band imaginary coherence) across sampled regions using brief (2 min) resting-state data segments. Bootstrapped logistic regression was used to generate a model to predict epileptogenicity of individual regions.

RESULTS
Compared to nonepileptogenic structures, we found increased functional connectivity within epileptogenic regions (P < .05) and between epileptogenic areas and other structures (P < .01, paired t-tests, corrected). Epileptogenic areas also demonstrated higher clustering coefficient (P < .01) and betweenness centrality (P < .01), and greater decay of functional connectivity with distance (P < .05, paired t-tests, corrected). Our functional connectivity model to predict epileptogenicity of individual regions demonstrated an area under the curve of 0.78 and accuracy of 80.4%.

CONCLUSION
Our study represents a preliminary step towards defining resting-state SEEG functional connectivity patterns to help localize epileptogenic brain regions ahead of neurosurgical treatment without requiring seizure recordings.
Vaccination, Risks, and Freedom: The Seat Belt Analogy
Authors: Giubilini Alberto , Savulescu Julian 
Published: September 2019

AbstractWe argue that, from the point of view public health ethics, vaccination is significantly analogous to seat belt use in motor vehicles and that coercive vaccination policies are ethically justified for the same reasons why coercive seat belt laws are ethically justified. We start by taking seriously the small risk of vaccines’ side effects and the fact that such risks might need to be coercively imposed on individuals. If millions of individuals are vaccinated, even a very small risk of serious side effects implies that, statistically, at some point side effects will occur. Imposing such risks raises issues about individual freedom to decide what risks to take on oneself or on one’s children and about attribution of responsibility in case of adverse side effects. Seat belt requirements raise many of the same ethical issues as vaccination requirements, and seat belt laws initially encountered some opposition from the public that is very similar to some of the current opposition to vaccine mandates. The analogy suggests that the risks of vaccines do not constitute strong enough reasons against coercive vaccination policies and that the same reasons that justify compulsory seat belt use—a measure now widely accepted and endorsed—also justify coercive vaccination policies.
Desire and Satisfaction
Authors: Shaw Ashley 
Published: September 2019

AbstractDesire satisfaction has not received detailed philosophical examination. Yet intuitive judgments about the satisfaction of desires have been used as data points guiding theories of desire, desire content, and the semantics of ‘desire’. This paper examines desire satisfaction and the standard propositional view of desire. Firstly, I argue that there are several distinct concepts of satisfaction. Secondly, I argue that separating them defuses a difficulty for the standard view in accommodating desires that Derek Parfit described as ‘implicitly conditional on their own persistence’, a problem posed by Shieva Kleinschmidt, Kris McDaniel, and Ben Bradley. The solution undercuts a key motivation for rejecting the standard view in favour of more radical accounts proposed in the literature.
Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization
Authors: Paul Friedman Katie , Gagne Matthew , Loo Lit-Hsin , Karamertzanis Panagiotis , Netzeva Tatiana , Sobanski Tomasz , Franzosa Jill A , Richard Ann M , Lougee Ryan R , Gissi Andrea , Lee Jia-Ying Joey , Angrish Michelle , Dorne Jean Lou , Foster Stiven , Raffaele Kathleen , Bahadori Tina , Gwinn Maureen R , Lambert Jason , Whelan Maurice , Rasenberg Mike , Barton-Maclaren Tara , Thomas Russell S 
Published: September 2019

AbstractUse of high-throughput, in vitro bioactivity data in setting a point-of-departure (POD) has the potential to accelerate the pace of human health safety evaluation by informing screening-level assessments. The primary objective of this work was to compare PODs based on high-throughput predictions of bioactivity, exposure predictions, and traditional hazard information for 448 chemicals. PODs derived from new approach methodologies (NAMs) were obtained for this comparison using the 50th (PODNAM, 50) and the 95th (PODNAM, 95) percentile credible interval estimates for the steady-state plasma concentration used in in vitro to in vivo extrapolation of administered equivalent doses. Of the 448 substances, 89% had a PODNAM, 95 that was less than the traditional POD (PODtraditional) value. For the 48 substances for which PODtraditional &lt; PODNAM, 95, the PODNAM and PODtraditional were typically within a factor of 10 of each other, and there was an enrichment of chemical structural features associated with organophosphate and carbamate insecticides. When PODtraditional &lt; PODNAM, 95, it did not appear to result from an enrichment of PODtraditional based on a particular study type (eg, developmental, reproductive, and chronic studies). Bioactivity:exposure ratios, useful for identification of substances with potential priority, demonstrated that high-throughput exposure predictions were greater than the PODNAM, 95 for 11 substances. When compared with threshold of toxicological concern (TTC) values, the PODNAM, 95 was greater than the corresponding TTC value 90% of the time. This work demonstrates the feasibility, and continuing challenges, of using in vitro bioactivity as a protective estimate of POD in screening-level assessments via a case study.
Comparison of Male and Female Resident Milestone Assessments During Emergency Medicine Residency Training: A National Study
Authors: Santen Sally A. , Yamazaki Kenji , Holmboe Eric S. , Yarris Lalena M. , Hamstra Stanley J. 
Published: September 2019

Purpose
A previous study found that milestone ratings at the end of training were higher for male than for female residents in emergency medicine (EM). However, that study was restricted to a sample of 8 EM residency programs and used individual faculty ratings from milestone reporting forms that were designed for use by the program’s Clinical Competency Committee (CCC). The objective of this study was to investigate whether similar results would be found when examining the entire national cohort of EM milestone ratings reported by programs after CCC consensus review.

Method
This study examined longitudinal milestone ratings for all EM residents (n = 1,363; 125 programs) reported to the Accreditation Council for Graduate Medical Education every 6 months from 2014 to 2017. A multilevel linear regression model was used to estimate differences in slope for all subcompetencies, and predicted marginal means between genders were compared at time of graduation.

Results
There were small but statistically significant differences between males’ and females’ increase in ratings from initial rating to graduation on 6 of the 22 subcompetencies. Marginal mean comparisons at time of graduation demonstrated gender effects for 4 patient care subcompetencies. For these subcompetencies, males were rated as performing better than females; differences ranged from 0.048 to 0.074 milestone ratings.

Conclusions
In this national dataset of EM resident milestone assessments by CCCs, males and females were rated similarly at the end of their training for the majority of subcompetencies. Statistically significant but small absolute differences were noted in 4 patient care subcompetencies.
Intergenerational Effects of Sevoflurane in Young Adult Rats
Authors: Ju Ling-Sha , Yang Jiao-Jiao , Xu Ning , Li Jia , Morey Timothy E. , Gravenstein Nikolaus , Seubert Christoph N. , Setlow Barry , Martynyuk Anatoly E. 
Published: September 2019

Abstract

Editor’s Perspective

What We Already Know about This Topic

What This Article Tells Us That Is New

Background
Sevoflurane administered to neonatal rats induces neurobehavioral abnormalities and epigenetic reprogramming of their germ cells; the latter can pass adverse effects of sevoflurane to future offspring. As germ cells are susceptible to reprogramming by environmental factors across the lifespan, the authors hypothesized that sevoflurane administered to adult rats could induce neurobehavioral abnormalities in future offspring, but not in the exposed rats themselves.

Methods
Sprague-Dawley rats were anesthetized with 2.1% sevoflurane for 3 h every other day between postnatal days 56 and 60. Twenty-five days later, exposed rats and nonexposed controls were mated to produce offspring.

Results
Adult male but not female offspring of exposed parents of either sex exhibited deficiencies in elevated plus maze (mean ± SD, offspring of both exposed parents vs. offspring of control parents, 35 ± 12 vs. 15 ± 15 s, P < 0.001) and prepulse inhibition of acoustic startle (offspring of both exposed parents vs. offspring of control parents, 46.504 ± 13.448 vs. 25.838 ± 22.866%, P = 0.009), and increased methylation and reduced expression of the potassium ion-chloride ion cotransporter KCC2 gene (Kcc2) in the hypothalamus. Kcc2 was also hypermethylated in sperm and ovary of the exposed rats. Surprisingly, exposed male rats also exhibited long-term abnormalities in functioning of the hypothalamic-pituitary-gonadal and -adrenal axes, reduced expression of hypothalamic and hippocampal Kcc2, and deficiencies in elevated plus maze (sevoflurane vs. control, 40 ± 24 vs. 25 ± 12 s, P = 0.038) and prepulse inhibition of startle (sevoflurane vs. control, 39.905 ± 21.507 vs. 29.193 ± 24.263%, P < 0.050).

Conclusions
Adult sevoflurane exposure affects brain development in male offspring by epigenetically reprogramming both parental germ cells, while it induces neuroendocrine and behavioral abnormalities only in exposed males. Sex steroids may be required for mediation of the adverse effects of adult sevoflurane in exposed males.
Factors Affecting Time NICU Nurses Spend With Fathers
Authors: Clarkson Gina , Gilmer Mary Jo 
Published: September 2019

Background:
Father involvement in the neonatal intensive care unit (NICU) is important for outcomes of children and should be encouraged. Neonatal nurses have been identified as a major source of support for fathers; yet, nurses have identified obstacles to family-centered care of the father.

Purpose:
The purpose of this article is to present results that broaden the knowledge of factors that affect time NICU nurses spend with fathers. The information presented here is a portion of results from a larger survey that examined factors affecting NICU nurse caring beliefs of fathers.

Methods:
This survey study included NICU nurses and was administered anonymously online. Content analysis was completed on responses to open-ended questions.

Results:
Questions asked nurses about the time they spend with fathers. Nurses described problems with workflow and encouraged family bonding. Some nurses described spending equal amounts of time with both parents, whereas others focused on either the mother or the father. Paternal attributes that affected time nurses spent with fathers included confidence, motivation, level of competence, beliefs, attitudes, and availability. Maternal factors included culture and gatekeeping. Infant factors were level of illness and tolerance to activity.

Implications for Practice:
Unmotivated fathers may benefit from encouragement from nurses to participate in the care of their infants. Nurses can encourage parental partnerships in caring for their infants.

Implications for Research:
Factors identified in this study can help guide future studies. Understanding the relationship between NICU fathers and nurses can help improve interactions and communication.
Autophagy-related Proteins as a Prognostic Factor of Patients With Colorectal Cancer
Authors: Koustas Evangelos , Sarantis Panagiotis , Theoharis Stamatios , Saetta Angelica A. , Chatziandreou Ilenia , Kyriakopoulou Georgia , Giannopoulou Ioanna , Michelli Maria , Schizas Dimitrios , Papavassiliou Athanasios G. , Karamouzis Michalis V. 
Published: September 2019

Objectives:
Autophagy plays a dual role in tumorigenesis. In the initial stages, it promotes cell survival and suppresses carcinogenesis, whereas in cancer development, it induces cancer cell survival. In this study, we investigate the role of autophagy as a protective or tumor suppressor mechanism in colorectal cancer (CRC) cell lines and evaluate its role as a potential biomarker in human tumor samples.

Materials and Methods:
The data of 68 patients with CRC treated at our Department from January 1 to December 31, 2016 were analyzed. Immunohistochemistry evaluation of p62, LC3B, Beclin-1, and Rab-7 in formalin-fixed paraffin-embedded tissue samples was performed and their expression was correlated with clinicopathologic characteristics, mutation status, and therapeutic approach. The χ2 was used to test an association among categorical variables. Survival curves were estimated using the Kaplan-Meier method and differences were assessed using the log-rank test. Colo-205, HT29, SW-480, and Caco-2 cell lines were also used so as to test the autophagy markers with oxaliplatin, irinotecan, hydroxychloroquine, and 3-methyladenine.

Results:
Overexpression of Beclin-1 is associated with poor survival (P=0.001) in patients with CRC treated with chemotherapy, irrespective of the stage and mutational status. Rab-7 is also correlated with progression-free survival (PFS) (P=0.088). Oxaliplatin (10 and 20 μΜ) and irinotecan (10 and 20 μΜ) inhibit autophagy in microsatellite stable (MSS) CRC cell lines. The inhibition of autophagy in MSS CRC cell lines after treatment with oxaliplatin and irinotecan is further identified through monodancylcadaverine staining. Moreover, inhibition of autophagy with molecules such as hydroxychloroquine (20 μΜ) and 3-methyladenine (5 mM) was identified by the accumulation of p62 and LC3B.

Conclusions:
Beclin-1 is an independent prognostic factor of overall survival and PFS. Also, Rab-7 is identified as an independent prognostic factor of PFS. Besides, several chemotherapeutic drugs such as oxaliplatin and irinotecan inhibit autophagy in MSS CRC cell lines in a similar way like hydroxychloroquine and 3-methyladenine. Thus, in MSS patients who develop chemoresistance, a combination of other therapies that include an autophagy inhibitor could be more beneficial. Further clinical trials are needed to investigate these therapeutic strategies.
Cutaneous Ultrasound for Tumor Thickness Measurement in Squamous Cell Carcinoma: The Effect of Neoadjuvant Intralesional Methotrexate in 40 Patients
Authors: Bergón-Sendín Marta , Pulido-Pérez Ana , Carretero López Fernando , Díez-Sebastián Jesús , Suárez-Fernández Ricardo 
Published: September 2019

BACKGROUND
Intralesional methotrexate (il-MTX) has been used as neoadjuvant therapy for cutaneous squamous cell carcinoma (cSCC) but studies on its effects on tumor thickness are lacking.

OBJECTIVE
The objective of this study was to evaluate il-MTX response with ultrasound examination.

METHODS
The authors conducted a prospective study in 40 patients with histologically confirmed cSCC. Neodjuvant il-MTX therapy was administered before surgery. Ultrasound evaluation was performed before the first infiltration and before surgical treatment.

RESULTS
Response to neoadjuvant treatment was observed in 92.5% of patients, both clinically and sonographically. There was a good correlation between both types of measurements, with r = 0.892 for the minor diameter and r = 0.944 for the major diameter (p < .001). The authors found an ultrasound overestimation compared to the clinical measurements in 92.5% of patients (mean overestimation: 1.08 mm). There was a good correlation between ultrasound and histological measurements in tumor thickness with r = 0.932 (p < .01), with an ultrasound overestimation in 97.5% of cases (mean overestimation: 0.90 mm).

CONCLUSION
Neoadjuvant il-MTX can reduce not only surface tumor dimensions but also tumor thickness. Ultrasound improves treatment response control with greater accuracy than clinical assessment alone.
PARACENTRAL ACUTE MIDDLE MACULOPATHY AFTER AORTIC ANEURYSM REPAIR
Authors: Lando Leonardo , Isaac David Leonardo C. , Avila Marcos P. 
Published: September 2019

Purpose:
We report a case of paracentral acute middle maculopathy secondary to cholesterol embolization syndrome after an endovascular aortic aneurism repair (EVAR).

Methods:
Functional and anatomical damage was assessed by Snellen visual acuity, fundoscopy, and optical coherence tomography.

Results:
A 67-year-old man presented with sudden vision loss in the right eye for one day with concomitant livedo reticularis in both feet. His medical history included an abdominal EVAR repair three days before the symptoms. The best-corrected visual acuity was 20/40 in the right eye and 20/20 in the left eye. Fundoscopy showed intraarteriolar cholesterol plaques (Hollenhorst) bilaterally, and a localized retinal whitening in the right eye. Optical coherence tomography at the lesion site revealed a hyperreflective band on the level of inner nuclear layer. The patient was referred for imaging and complete systemic evaluation. He was then closely followed up by a vascular team, without additional intervention. Retinal stigma partially regressed at six months with visual improvement.

Conclusion:
This case describes paracentral acute middle maculopathy as a rare ocular sign of cholesterol embolization in postoperative intraaortic operations. The diagnosis of this complication led to prompt clinical care with a multidisciplinary approach.
Clinical Outcomes and Endothelial Cell Density After Descemet Membrane Endothelial Keratoplasty Using Peripherally-trephinated Donor Tissue (DMEK-pD) in Fuchs Endothelial Corneal Dystrophy
Authors: Basak Samar K. , Basak Soham 
Published: September 2019

Purpose:
To evaluate the clinical outcomes and endothelial cell density (ECD) after Descemet membrane endothelial keratoplasty using peripherally trephinated donor tissue (DMEK-pD) and compare with DMEK using centrally trephinated donor tissue (DMEK-cD) in patients with Fuchs endothelial corneal dystrophy (FECD).

Methods:
This was a prospective comparative interventional case series. One hundred twenty-five eyes of 110 patients with FECD and cataract who underwent either DMEK-pD (n = 60) or DMEK-cD (n = 65) combined with phacoemulsification, between June 2016 and November 2018, were included. Preoperative and postoperative best spectacle-corrected visual acuity (BSCVA) and ECD were recorded at 6 months and 1 year.

Results:
All eyes had visually symptomatic FECD and cataract with a preoperative mean BSCVA of 1.03 logarithm of the minimum angle of resolution in both groups. Baseline donor mean ECD was 2944 ± 201 and 2907 ± 173 cells/mm2 in the DMEK-pD and DMEK-cD groups, respectively (P = 0.12). BSCVA improvement was comparable at 6 months and 1 year (P = 0.23 and P = 0.34). Mean ECD recorded after 6 months and 1 year was significantly higher in the DMEK-pD group than in the DMEK-cD group: 2508 ± 201 versus 2084 ± 298 cells/mm2 (P < 0.01) and 2338 ± 256 versus 1907 ± 339 cells/mm2 (P < 0.01), respectively. Complication rates were similar in both groups.

Conclusions:
DMEK-pD exhibited similar clinical outcomes with higher ECD compared with conventional DMEK-cD after 6 months and 1 year. The possibility of transplanting peripherally trephinated donor tissue in DMEK with more endothelial cells needs to be explored further in the future.