bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Invisible Tropical Tuber Crop: Edible Aroids (Araceae) Sold as “Tajer” in the Netherlands
Authors: Fang Qiong , Matthews Peter J. , Grimaldi Ilaria M. , de Jong Hans , van de Belt Jose , Schranz M. Eric , van Andel Tinde 
Published: October 2024

AbstractEdible aroids (plants from the family Araceae) are among the top five most cultivated tuber crops globally, but their consumer acceptance is hindered by acridity. Aroids contain sap that severely irritates the throat and lips if not properly processed. However, no in-depth studies exist on acridity in edible aroids and how to diminish it. We used ethnobotanical methods to document the diversity of edible aroids available in the Dutch marketplace and how consumers handle acridity. We grew corms in a greenhouse to obtain additional morphological information and used flow cytometry to assess ploidy. We collected 73 samples and interviewed 71 people. At least three species, Colocasia esculenta, Xanthosoma violaceum, and Caladium bicolor, were sold under the generic name “tajer.” Different plant parts with various forms of processing were imported from diverse geographic origins and sold mainly to immigrant customers. Interviewees mentioned various processing methods to avoid and reduce acridity. We distinguished nine cultivar groups of Colocasia esculenta and four of Xanthosoma violaceum. Both Colocasia esculenta and Xanthosoma violaceum were also cultivated in Dutch greenhouses. We present the first report on edible aroids cultivation in northern Europe and draw attention to the lack of labeling and cooking instructions.
Mechanical and Geometric Characterization of a Novel 2-Ply Vacuum-Pressed Biological Scaffold Patch Design for Posterior Mitral Valve Reconstruction
Authors: Jedrzejczyk Johannes H. , Andersen Frederik T. , Petersen Jacob , Kaspersen Alexander Emil , Sahana Urjosee , Skov Søren N. , Væsel Jens T. , Hasenkam J. Michael , Tjørnild Marcell J. 
Published: October 2024

AbstractTo assess the mechanical properties of small intestinal submucosal extracellular matrix (SIS-ECM) iterations and choose the optimal version for evaluating functional geometrics after posterior mitral valve reconstruction. Four SIS-ECM versions (2- and 4-ply vacuum-pressed and lyophilized) underwent uniaxial tensile testing. A posterior mitral valve reconstruction patch was developed based on MRI scans (n = 5). Posterior mitral valve reconstruction using 2-ply vacuum-pressed SIS-ECM was performed (n = 7), and geometrics were evaluated using a modified left heart simulator. The vacuum-pressed iterations displayed superior maximum stress values compared to lyophilized (2-ply: median [IQR], 15.8 [15.2–19.0] vs 7.9 [7.3–8.3] MPa, p < 0.001; 4-ply: median (IQR), 15.8 –[14.6–22.0] vs 7.9 [7.6–8.4] MPa). All reconstructed valves were competent with preserved total leaflet area, but individual leaflet segment areas were redistributed. Posterior mitral valve reconstruction with our 2-ply vacuum-pressed SIS-ECM patch design was feasible in vitro. Further in vivo evaluation is warranted.
Graphical Abstract
Optimizing a thermoelectric window frame for heating and cooling: A cross-validated simulation study
Authors: He Zhineng , Zuazua-Ros Amaia , Martín-Gómez César 
Published: October 2024

AbstractBeyond the design of the system components, the potential application of thermoelectric (TE) systems is influenced by various factors in the control process. To understand the effects of these control factors on TE system performance in buildings, computational models for a TE window frame are established. In this work, two different numerical methodologies are applied to calculate the desired operating current and temperature distributions within the airflows and on the surfaces of the Peltier cells. The simulation results obtained from these methodologies are cross-validated and compared with relevant experimental results from existing studies. The mathematical model iterates the outgoing airflow temperature at non-object sides after determining the object-side temperature under a certain heat load. Additionally, alongside the number of activated Peltier cells and airflow rate, a new factor, termed the distribution of power strength, is considered in the analysis. The results indicate that homogeneous power strength across each Peltier cell yields favorable outcomes in both heating and cooling modes. The coefficient of performance (COP) increases with the activation of more Peltier cells under a constant heat load, while begins to decline beyond a certain threshold. Moreover, the COP is enhanced with a relatively higher airflow rate by strengthening the heat transfer to relieve the temperature difference between both sides. Consequently, based on the result analysis, we propose an optimization strategy for TE systems. This strategy aims to optimize operating currents, the number of working Peltier cells, and operating airflow rates, particularly when working conditions fluctuate.
Resurrection of the parasitic isopod genus Cryptione Hansen, 1897 (Epicaridea: Bopyridae) and description of a new species of parasitic isopod (Epicaridea: Bopyridae) from the deep-sea shrimp Notostomus gibbosus (Caridea: Acanthephyridae) with an analysis of its phylogenetic position based on molecular data
Authors: Williams Jason D. , Horch Amanda P. , Ceballos Angela , Bracken-Grissom Heather 
Published: October 2024

AbstractA new species of pseudionine parasite is described from the deep-sea shrimp Notostomus gibbosus A. Milne-Edwards, 1881, collected in the Gulf of Mexico, the first record of a bopyrid parasitizing any member of the family Acanthephyridae Spence Bate, 1888. Morphological and molecular data are provided to support the inclusion of the new species and 12 other branchial ectoparasites of caridean shrimps in the genus Cryptione Hansen, 1897 that is resurrected herein. Cryptione is sister to the genus Pseudione sensu stricto, ectoparasites of axiid and callianassid shrimps as well as nephropid lobsters. The new species Cryptione grandis can be distinguished from its closest congeners including C. parviramus (Adkison, 1988) from the Gulf of Mexico by several female and male characters. The epicaridium larvae of C. grandis were examined with scanning electron microscopy (SEM), only the second description of this stage for any species in the genus. A table listing all species in Cryptione and taxonomic notes on some species are provided.
Friction in soft biological systems and surface self-organization: the role of viscoelasticity
Authors: Pajic-Lijakovic Ivana , Milivojevic Milan , McClintock Peter V. E. 
Published: October 2024

Abstract
Friction is a critical factor in the proper functioning of human organs as well as in the potential development of disease. It is also important for the design of diagnostic and interventional medical devices. Nanoscale surface roughness, viscoelastic or plastic deformations, wear, and lubrication all influence the functions of individual cells. The effects of friction in soft matter systems are quantified using different types of frictional coefficients, including the dynamic friction coefficient, friction-skin drag, and pressure drag. These coefficients are determined by the viscoelastic properties of the two systems in contact and their relative velocity. In this review, several biological systems are considered, including (i) epithelial tissues in contact with soft hydrogel-like implants, (ii) the collective migration of epithelial monolayers on substrate matrices, (iii) blood flow through blood vessels, and (iv) the movement of cancer cells past epithelial clusters along with the migration of epithelial cells within the cluster.
First report of iris yellow spot virus infecting shallot (Allium cepa var. aggregatum) in Australia
Authors: Nurulita Sari , Geering Andrew D. W. , Crew Kathleen S. , Harper Stephen , Thomas John E. 
Published: October 2024

AbstractIn 2019, symptoms typical of infection by iris yellow spot virus (IYSV; family Tospoviridae, genus Orthotospovirus) were observed on shallot (A. cepa var. aggregatum) grown at the Gatton Research Facility, Department of Agriculture and Fisheries, Queensland. Initial testing by DAS-ELISA was positive for IYSV, and subsequent specific RT-PCR amplifying part of the RdRp (L-segment) and sequencing of amplicons confirmed the IYSV infection. This is the first record of IYSV infection of shallot in Australia.
Evaluating Factors Affecting Flood Susceptibility in the Yangtze River Delta Using Machine Learning Methods
Authors: Zhu Kaili , Wang Zhaoli , Lai Chengguang , Li Shanshan , Zeng Zhaoyang , Chen Xiaohong 
Published: October 2024

AbstractFloods are widespread and dangerous natural hazards worldwide. It is essential to grasp the causes of floods to mitigate their severe effects on people and society. The key drivers of flood susceptibility in rapidly urbanizing areas can vary depending on the specific context and require further investigation. This research developed an index system comprising 10 indicators associated with factors and environments that lead to disasters, and used machine learning methods to assess flood susceptibility. The core urban area of the Yangtze River Delta served as a case study. Four scenarios depicting separate and combined effects of climate change and human activity were evaluated using data from various periods, to measure the spatial variability in flood susceptibility. The findings demonstrate that the extreme gradient boosting model outperformed the decision tree, support vector machine, and stacked models in evaluating flood susceptibility. Both climate change and human activity were found to act as catalysts for flooding in the region. Areas with increasing susceptibility were mainly distributed to the northwest and southeast of Taihu Lake. Areas with increased flood susceptibility caused by climate change were significantly larger than those caused by human activity, indicating that climate change was the dominant factor influencing flood susceptibility in the region. By comparing the relationship between the indicators and flood susceptibility, the rising intensity and frequency of extreme precipitation as well as an increase in impervious surface areas were identified as important reasons of heightened flood susceptibility in the Yangtze River Delta region. This study emphasized the significance of formulating adaptive strategies to enhance flood control capabilities to cope with the changing environment.
Open Innovation and Regulatory Challenges in New Modality Development: The Pivotal Role of Contract Development and Manufacturing Organisations in Advancing Antibody Drugs
Authors: Yoshiura Hiromu , Kawata Yayoi , Sengoku Shintaro 
Published: October 2024

Abstract
Background
Ensuring regulatory-compliant manufacturing capability is an essential challenge for new treatment modalities, but its internalisation is not easy for pharmaceutical companies, especially start-ups. This study examines the functions and requirements of contracted development and manufacturing organisations (CDMOs) using the development process of antibody medicines as a case study.

Methods
Utilizing PubMed, Cortellis and Patent Integration databases, this study delves into publication and contractual trends in monoclonal antibody drugs (mAbs) development, alongside an analysis of patent filings by CDMOs, offering a comprehensive overview of the evolving landscape in mAbs innovation.

Results
In the early stages of mAbs development, dedicated bio firms (DBFs) led R&D with superior drug discovery technology but lacked manufacturing capability, which was complemented by CDMOs. This collaboration was an opportunity for CDMOs to expand their capabilities beyond manufacturing technology into antibody drug candidate discovery and structural optimisation technology. From mid-development onwards, it established a technology platform based on these capabilities and developed and established partnerships with existing pharmaceutical companies, including mega pharma.

Conclusions
The impact of institutions and regulations on the innovation process was assessed during this development process. These findings are expected to provide valuable insights into the innovation system for new modalities.
In-situ engineering of native extracellular matrix to improve vascularization and tissue regeneration at the ischemic injury site
Authors: Hao Dake , Lu Lu , Song Hengyue , Lopez Juan-Maria , Liu Ruiwu , Zhou Ping , Nolta Jan , Farmer Diana L. , Kurzrock Eric , Panitch Alyssa , Lam Kit S. , Wang Aijun 
Published: October 2024

AbstractIschemic injury causes dynamic damage to the native extracellular matrix (ECM), which plays a key role in tissue homeostasis and regeneration by providing structural support, facilitating force transmission, and transducing key signals to cells. The main approach aimed at repairing injury to ischemic tissues is restoration of vascular function. Due to their potential to form capillary niches, endothelial cells (ECs) are of greatest interest for vascular regeneration. Integrin binding to ECM is crucial for cell anchorage to the surrounding matrix, spreading, migration, and further activation of intracellular signaling pathways. In this study, we proposed to establish an in-situ engineering strategy to remodel the ECM at the ischemic site to guide EC endogenous binding and establish effective EC/ECM interactions to promote revascularization. We designed and constructed a dual-function molecule (LXW7)2-SILY, which is comprised of two functional domains: the first one (LXW7) binds to integrin αvβ3 expressed on ECs, and the second one (SILY) binds to collagen. In vitro, we confirmed (LXW7)2-SILY improved EC adhesion and survival. After in situ injection, (LXW7)2-SILY showed stable retention at the injured area and promoted revascularization, blood perfusion, and tissue regeneration in a mouse hindlimb ischemia model.
Graphical Abstract
Enhancing Agrobacterium-mediated soybean transformation efficiency with an auxiliary solution
Authors: Chen Luying , Wang Liang , Zhang Lei , Li Yongguang , Han Shaojie 
Published: October 2024

AbstractSoybean is a crucial source of oil, protein, and biofuel, necessitating efficient transformation systems for advancing research. Agrobacterium-mediated transformation is currently the primary method used in the soybean transformation industry and scientific research. However, the low efficiency and genotype dependency of this technology leave significant room for improvement. This study aimed to enhance soybean transformation efficiency by generating and validating three reporter vectors (ZsGreen, TdTomato, and Ruby) and using Agrobacterium Auxiliary Solution (AAS) containing Silwet L-77 and hormone mixtures. Our findings demonstrate that AAS significantly improves hairy root transformation rates. Specifically, this combination increased total root and cotyledon transformation efficiencies compared to the control. We also found that larger vectors like Ruby reduced transformation efficiency compared to smaller markers like GFP and RFP. Furthermore, AAS slightly reduced the co-transformation rate of two separate vectors compared to single vector transformations. Additionally, AAS enhanced soybean hypocotyl transformation rates across various varieties, consistently increasing positive root and explant efficiencies. Notably, transformation rates varied significantly between varieties, with Forrest differing from Williams 82 and Dongnong 50. This research highlights the importance of auxiliary agents and vector size in optimizing soybean transformation, providing insights for future advancements in genetic modification and biotechnology.
Molecular Testing of Central Nervous System Tumours: Recommendations of the Canadian Association of Neuropathologists
Authors: Munoz David G. , Gao Andrew , Hammond Robert , Schutz Peter W. , Gray Madison , Hawkins Cynthia 
Published: October 2024

ABSTRACT:
The diagnosis of central nervous system tumours has been transformed in recent years from a microscopic morphology-based process to one dominated by the identification of somatic genetic alterations in tumour cells. This switch requires implementing radically different methods, for which appropriate training and financial resources must be allocated. The Canadian Association of Neuropathologists (CANP) has followed a process based on the scientific literature and consensus to develop recommendations for molecular testing of tumours of the brain and spinal cord, aiming to balance the need for treatment-determinant accurate diagnosis and the current limitations inherent in the transition to a new paradigm. The Professional Affairs Committee was charged with this task. A draft was discussed during the CANP general assembly, along with presentations from groups who had implemented molecular technologies, as well as others who relied on external laboratories. The Professional Affairs Committee summarised the consensus and submitted their recommendation to the CANP’s Executive Committee. A final report was posted on the CANP website for a month to allow all members to comment. The recommendations below apply to intrinsic tumours of the central nervous system and do not include metastatic disease or tumours impinging upon the nervous system from outside. These recommendations should be considered clinically relevant, as the results have direct consequences on the patient’s treatment, either through the use of targeted therapies or the trial-proven best application of radiation and/or chemotherapy.
Molecular symphonies and signalling pathways orchestrated by the gut microbiome in metastatic colorectal cancer (mCRC); a state-of-the-art review
Authors: Fatemi Nayeralsadat , Jahdkaran Mahtab , Mirbahari Seyedeh Nasim , Houri Hamidreza 
Published: October 2024

Abstract
The role of oncobiosis, characterized by dysregulated microbial ecosystems associated with cancer, has been increasingly acknowledged in promoting the metastasis and dissemination of tumour cells. A comprehensive understanding of the complex interactions between the gut microbiome and metastatic colorectal cancer (mCRC) presents promising avenues for the development of innovative therapeutic approaches centred around modulating the gut microbiome to prevent or hinder metastatic spread. In this comprehensive review, we aim to provide a molecularly focused summary of the implications of the human gut microbiome and microbial metabolites in the initiation and advancement of mCRC. By elucidating these intricate mechanisms, we strive to establish a foundation for future research and the design of novel interventions targeting the gut microbiome to combat this devastating disease.
On possible limit functions on a Fatou component in non-autonomous iteration
Authors: COMERFORD MARK , STANISZEWSKI CHRISTOPHER 
Published: October 2024

AbstractThe possibilities for limit functions on a Fatou component for the iteration of a single polynomial or rational function are well understood and quite restricted. In non-autonomous iteration, where one considers compositions of arbitrary polynomials with suitably bounded degrees and coefficients, one should observe a far greater range of behavior. We show this is indeed the case and we exhibit a bounded sequence of quadratic polynomials which has a bounded Fatou component on which one obtains as limit functions every member of the classical Schlicht family of normalized univalent functions on the unit disc. The proof is based on quasiconformal surgery and the use of high iterates of a quadratic polynomial with a Siegel disc which closely approximate the identity on compact subsets. Careful bookkeeping using the hyperbolic metric is required to control the errors in approximating the desired limit functions and ensure that these errors ultimately tend to zero.
Piecewise contractions
Authors: JAIN SAKSHI , LIVERANI CARLANGELO 
Published: October 2024

Abstract
We study piecewise injective, but not necessarily globally injective, contracting maps on a compact subset of

${\mathbb R}^d$

. We prove that, generically, the attractor and the set of discontinuities of such a map are disjoint, and hence the attractor consists of periodic orbits. In addition, we prove that piecewise injective contractions are generically topologically stable.
Surface energy and mass balance of Mera Glacier (Nepal, Central Himalaya) and their sensitivity to temperature and precipitation
Authors: Khadka Arbindra , Brun Fanny , Wagnon Patrick , Shrestha Dibas , Sherpa Tenzing Chogyal 
Published: October 2024

Abstract
The sensitivity of glacier mass balance to temperature and precipitation variations is crucial for informing models that simulate glaciers’ response to climate change. In this study, we simulate the glacier-wide mass balance of Mera Glacier with a surface energy-balance model, driven by in situ meteorological data, from 2016 to 2020. The analysis of the share of the energy fluxes of the glacier shows the radiative fluxes account for almost all the energy available during the melt season (May–October). However, turbulent fluxes are significant outside the monsoon (June–September). On an annual scale, melt is the dominant mass flux at all elevations, but 44% of the melt refreezes across the glacier. By reshuffling the available observations, we create 180 synthetic series of hourly meteorological forcings to force the model over a wide range of plausible climate conditions. A +1 (−1)°C change in temperature results in a −0.75 ± 0.17 (+0.93 ± 0.18) m w.e. change in glacier-wide mass balance and a +20 (−20)% change in precipitation results in a +0.52 ± 0.10 (−0.60 ± 0.11) m w.e. change. Our study highlights the need for physical-based approaches to produce consistent forcing datasets, and calls for more meteorological and glaciological measurements in High Mountain Asia.
Multi-decadal evolution of Crary Ice Rise region, West Antarctica, amid modern ice-stream deceleration
Authors: Verboncoeur Hannah , Siegfried Matthew Ross , Holschuh Nicholas , Winberry Jeremy Paul , Byrne Duncan , Sauthoff Wilson , Sutterley Tyler Clark , Medley Brooke 
Published: October 2024

Abstract
The ongoing deceleration of Whillans Ice Stream, West Antarctica, provides an opportunity to investigate the co-evolution of ice-shelf pinning points and ice-stream flux variability. Here, we construct and analyze a 20-year multi-mission satellite altimetry record of dynamic ice surface-elevation change (dh/dt) in the grounded region encompassing lower Whillans Ice Stream and Crary Ice Rise, a major pinning point of Ross Ice Shelf. We developed a new method for generating multi-mission time series that reduces spatial bias and implemented this method with altimetry data from the Ice, Cloud, and land Elevation Satellite (ICESat; 2003–09), CryoSat-2 (2010–present), and ICESat-2 (2018–present) altimetry missions. We then used the dh/dt time series to identify persistent patterns of surface-elevation change and evaluate regional mass balance. Our results suggest a persistent anomalous reduction in ice thickness and effective backstress in the peninsula connecting Whillans Ice Plain to Crary Ice Rise. The multi-decadal observational record of pinning-point mass redistribution and grounding zone retreat presented in this study highlights the on-going reorganization of the southern Ross Ice Shelf embayment buttressing regime in response to ice-stream deceleration.
Context and Neural Function
Authors: Barack David L 
Published: October 2024

AbstractThe debate over context and neural function pits contextualists, who maintain that neural functions vary by context, against invariantists, who maintain that they do not. In this article, I defend a moderate position that permits some context sensitive yet invariant functions. I distinguish performance from competence as well as different types of contexts, accounting for many cases of variability by context. The discussion suggests changes in networks can sometimes change the competences of parts. I conclude that some context sensitivity of function is consistent with invariant functions whereas other changes in context imply changes in the competence to perform functions.