bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics and prognosis of steroid-resistant nephrotic syndrome in children: a multi-center retrospective study
Authors: Li Sheng , He Chao , Sun Yu , Chen Jie , Liu Yunguang , Huang Zengpo , Huang Weifang , Meng Yongqiu , Liu Wenjing , Lei Xianqiang , Zhao Rihong , Lin Zihui , Huang Chunlin , Lei Fengying , Qin Yuanhan 
Published: November 2024

Abstract
Background
This study investigated the factors influencing the prognosis of children with steroid-resistant nephrotic syndrome (SRNS) in patients from the Guangxi region.

Methods
We retrospectively analyzed clinical and pathological data of 279 patients with SRNS from six tertiary hospitals in Guangxi. Clinical data were compared between initial (I-SRNS) and secondary (S-SRNS) steroid resistance subgroups and Cox regression analysis was used to determine risk factors for chronic kidney disease (CKD) and CKD stage 5 (CKD5) in patients with SRNS.

Results
The median age of onset was 54 months. Thirty-three patients had extra-kidney manifestations. Fifty-two, 24, 57, 33, and 41 patients had hypertension, acute kidney injury, vitamin D deficiency, high intraocular pressure, and dwarfism, respectively. One hundred eighty-two and 92 patients had I-SRNS and S-SRNS, respectively. There were significant differences in sex, ethnicity, family history, incidence of hematuria, clinical classification, efficacy of immune agents, and prognosis between groups (P < 0.05). Among the 279 cases of SRNS, 239 had normal kidney function, 37 developed CKD, and 16 had CKD5. An increase in serum creatinine level (HR = 1.003) was significantly associated with CKD in children with SRNS, and effective immunosuppressant therapy decreased the CKD risk (HR = 0.168). Patients with increased serum creatinine levels (HR = 1.003) and acute kidney injury (HR = 4.829) were more likely to progress to CKD5.

Conclusions
Children with S-SRNS showed a higher response to immunosuppressants than those with I-SRNS. Effective immunosuppressant therapy was found to protect against CKD, whereas increased acute kidney injury was an independent risk factor for CKD5.
Detection and molecular characterization of carbapenem-resistant gram-negative bacterial isolates
Authors: Mustafa Aliaa A. , Abushady Hala , Roshdy Reda , Elateek Sawsan Y. , El Essawy Ayman K. 
Published: November 2024

AbstractAntimicrobial-resistant bacteria (ARB) are responsible for increased mortality and morbidity. Therefore, this study focuses on evaluating traditional and molecular diagnostic tools of carbapenem-resistant gram-negative bacteria (CRGNB). In order to achieve this, 94 samples, from different patients’ specimens, and surrounding environment, were collected from intensive care units (ICUs) at Ain Shams University Specialized Hospital and the National Cancer Institute, Cairo, Egypt. The swabs were cultured on appropriate media, including Chromogenic medium (HiCrome KPC Agar Base “HIMEDI AM1831”), and MacConkey-10 µg imipenem disc resulting in 136 isolates with different culture characteristics. Next, the selected isolates were subjected to VITEK 2 machine and 16SrRNA (16 S ribosomal RNA) sequencing. The sensitivity of HiCROME KPC agar for CRGNB detection was 99.3% and 94.7%, in reference to the MacConkey-disc and VITEK-2 methods, respectively. The HiCrome KPC agar assumptions for bacterial identification were not as consistent as those of VITEK 2 (with only 47.4% agreement) and 16SrRNA gene sequencing analysis. The approaches discussed in this study facilitate providing rapid diagnosis and treatment of CRGNB, which helps increase survival rates. HiCrome KPC agar is considered a relatively accurate and easy method that can be used in any laboratory. In addition, the selected strains were deposited in the gene bank with the accession numbers OR553657, OR553658, and OR553659. It is noteworthy that Genus Acinetobacter is the major CRGNB isolated from the patients and environmental surfaces in the hospitals. This highlights the importance of proper environmental and terminal cleaning procedures in healthcare facilities and applying control measures to ensure infection prevention.
New strategies for lung cancer diagnosis and treatment: applications and advances in nanotechnology
Authors: Feng Jiaqi , Zhang Pengpeng , Wang Dingli , Li Yuting , Tan Jiaxiong 
Published: November 2024

AbstractLung cancer leads in causing cancer-related mortality worldwide, continually posing a significant threat to human health. Current imaging diagnostic techniques, while offering non-invasive detection, suffer from issues such as insufficient sensitivity and the risks associated with radiation exposure. Pathological diagnosis, the gold standard for confirmation, also faces challenges like invasiveness and high costs. In treatment, surgery, radiotherapy, and chemotherapy are the main modalities, each encountering challenges related to precision, environmental adaptability, and side effects. Nanotechnology’s advancement provides new solutions for the diagnosis and treatment of lung cancer, promising to enhance diagnostic accuracy and reduce side effects during treatment. This article introduces the main types of nanomaterials used in the field of lung cancer, offering a comprehensive overview of current research on the application of nanotechnology in early screening, diagnosis, treatment, and monitoring of lung cancer, and summarizing ongoing clinical research findings.
The Role of Delta-Opioid Receptor in Mediating the Cardioprotective Effects of Morphine Preconditioning via the JAK2/STAT3 Pathway in a Failing Heart
Authors: Pan Xinxin , Guo Chengxiao , Wang Baoli , Cao Biyun , Wu Juan , Chen Xinyu , He Shufang , Zhang Ye , Jin Shiyun 
Published: November 2024

BACKGROUND:
Failing heart is more likely to suffer from myocardial ischemia/reperfusion (I/R) injury. This poses a great challenge for anesthesiologists in managing patients with heart failure during major surgery. Evidence from animal studies suggests that the delta-opioid receptor (DOR) contributes to alleviating acute myocardial injuries. However, little is known regarding the cardioprotective effects of cardiac DOR in patients with chronic heart failure. This study aimed to examine DOR expression in failing hearts and explore how DOR regulates the Janus kinase signal transducer and activator of the transcription-3 (JAK/STAT3) pathway to mediate morphine-induced cardio protection in heart failure.

METHODS:
We measured the DOR protein levels in human and rat heart tissues with chronic heart failure. To investigate the cardioprotective role of DOR, we administered the DOR-specific antagonist, naltrindole (NTD), and JAK2 inhibitor, AG490, before morphine preconditioning (MPC) in an isolated perfusion model of myocardial I/R injury in postinfarcted failing rat heart. We examined the infarct size, cardiac enzymes, cardiac function, cardiomyocyte apoptosis, apoptosis-related proteins, and STAT3 phosphorylation in the heart.

RESULTS:
The protein levels of DOR were significantly elevated in the myocardial tissues of humans and rats with chronic heart failure, by 1.4-fold (mean difference 0.41; 95% confidence interval [CI], 0.04–0.78; P = .032) and 2.3-fold (mean difference 1.26; 95% CI, 0.25–2.28; P = .009), respectively, compared to control tissues. Disease severity positively correlated with DOR expression (human: R2 = 0.316, P = .004; rat: R2 = 0.871, P = .021). Blocking DOR substantially reversed the cardioprotective effects of MPC in postinfarcted rat hearts, increasing the mean (standard deviation) percentage of infarct size from 15.0 (3.9)% to 30.8 (7.7)% (P < .001). Similarly, AG490 inhibited MPC restoration of cardiomyocyte apoptosis (33.3 [4.2]% vs 16.6 [3.4]%; P < .001). Both NTD and AG490 markedly suppressed STAT3 phosphorylation by 60.1% (mean difference 0.60; 95% CI, 0.27–0.93; P = .002) and 44.1% (mean difference 0.44; 95% CI, 0.06–0.83; P = .027), respectively, and also lowered the Bcl-2/Bax ratio by 85.5% (mean difference 0.86; 95% CI, 0.28–1.43; P = .006) and 68.2% (mean difference 0.68; 95% CI, 0.51–0.85; P < .001) respectively in heart tissues at the end of reperfusion.

CONCLUSIONS:
DOR protein levels increased in failing hearts of both humans and rats. Blocking cardiac DOR selectively reduced morphine-induced cardio protection by inhibiting the JAK2/STAT3 pathway. These findings indicate that cardiac DOR is a potential therapeutic target for protecting against heart failure due to I/R injury.
The use of an overdenture in a patient with numerous partially erupted and unerupted teeth
Authors: Hudson Joshua , Choudhury Gulshana , Hemmings Ken 
Published: November 2024

Some medical conditions present with missing or malformed teeth and other unusual oral manifestations that complicate prosthodontic treatment. Outlining the simple and complicated treatment options to the patient allows them to make an informed decision about the treatment they wish to pursue. This report describes the management of a patient diagnosed with pseudohypoparathyroidism. Taking a patient-centred approach, with their involvement in the planning process, was essential to a successful outcome. CPD/Clinical Relevance: Adopting a holistic approach to treatment planning enables patients to make informed decisions, ensuring patient-centred care that not only targets the condition, but supports overall wellbeing.
Considerations in dental local anaesthesia for the patient with cleft lip and palate
Authors: Dilworth Daniel , Fahy Edward , Mian Mishaim A , Lordan Emily , O'Mahony Aisling 
Published: November 2024

Patients who have had a history of surgical repair of cleft lip and palate can often develop scar tissue post-operatively that can make it more difficult for dentists to achieve sufficient local anaesthesia. In addition, the presence of a cleft can result in anatomical variation of nerve supply to the maxillary region, which can result in further complications for achieving sufficient anaesthesia. This article reviews the anatomical variations that can occur, and posits a technique to allow for more predictable and successful local anaesthesia in this cohort of patients. CPD/Clinical Relevance: GDPs may have difficulty in achieving sufficient local anaesthesia for patients with a cleft lip and palate.
Fabrication of Cerium Oxide-Graphene Oxide Nanocomposite using Ultrasound-Assisted Precipitation Method
Authors: Nurhasanah Iis , Arvia Arvia , Prasetya Nor Basid Adiwibawa , Jauhari Ahmad 
Published: November 2024

<p class="Abstract">The cerium oxide-graphene oxide nanocomposite was fabricated by ultrasound-assisted precipitation method and characterized using Fourier transform infrared, UV-Vis spectroscopy, X-ray diffractometer, and transmission electron microscope. The Fourier transform infrared spectra displayed the vibrations of O-H, C=C, and C-H indicating the interaction between cerium oxide and graphene oxide. The broad absorption of around 300 nm is ascribed to the superposition of cerium oxide and graphene oxide absorption peaks. X-ray diffraction pattern analysis suggests the creation of graphene oxide nanosheets with an interlayer spacing of 0.821 nm. The transmission electron microscope image showed that the cerium oxide nanoparticles dispersed on the graphene oxide nanosheet. These findings exhibit the useful ultrasound-assisted precipitation method for fabricating cerium oxide-graphene oxide nanocomposite.</p>
Perioperative outcomes and hospitalization costs of radical vs. conservative surgery for hepatic cystic echinococcosis: A retrospective study
Authors: Shi Honggang , Tuerxun Kahaer , Yusupu Aizizaimu , Yusupu Zainuer , Xu Qilin , Jia Yibin , Maimaitireyimu Musitaba , Maimaitiaili Tuerhongaji , Muhetajiang Muzaipaer , Lin Jiaxin , Ma Chengmin , Li Xiaofeng , Wu Yuanquan , Su Yonghui 
Published: November 2024

Background
Surgical intervention is a crucial treatment for hepatic cystic echinococcosis. However, the choice between radical and conservative surgery remains controversial. This study aimed to compare the perioperative outcomes and hospitalization costs between radical and conservative surgery for hepatic cystic echinococcosis.

Method
A retrospective cohort study was conducted on patients undergoing surgical treatment at the First People’s Hospital of Kashi Prefecture from July 1, 2012, to October 1, 2023. Propensity score-matching analysis was utilized to mitigate patient selection bias between the two surgical groups.

Result
Of the 434 patients included, 324 underwent conservative surgery and 110 underwent radical surgery. After propensity score-matching, 182 conservative surgery and 102 radical surgery patients were compared. Radical surgery patients experienced longer operative time, higher intraoperative blood loss, increased blood transfusion, and higher costs compared to conservative surgery patients. However, no differences were observed in short-term outcomes, including overall morbidity, death, bile leak, effusion, pulmonary infection, incision infection, intestinal obstruction, ICU stay, abdominal drainage time, and postoperative hospital stays.

Conclusion
This study suggests that radical surgery is associated with greater surgical complexity and higher hospitalization costs, while it doesn’t offer a significant short-term advantage. Conservative surgery may be a viable option in resource-limited settings or for patients unsuitable for complex procedures. Further research with long-term follow-up is needed to determine the optimal approach.
Participants’ perspectives on a multimodal stress management and comprehensive lifestyle modification program for patients with Crohn’s disease—A qualitative interview study
Authors: Schlee Christoph , Uecker Christine , Öznur Özlem , Bauer Nina , Langhorst Jost 
Published: November 2024

Background
Crohn’s disease (CD) is a type of inflammatory bowel disease (IBD) that is prevalent worldwide and associated with reduced quality of life for patients. Multimodal therapy approaches, which emphasize lifestyle modifications such as mindfulness and stress reduction, can be promising in enhancing health-related quality of life for IBD patients. However, research on multimodal therapy approaches for CD remains insufficient.

Method
This qualitative interview study is part of a mixed-methods approach that is embedded in a randomized controlled trial. It investigates the impact of a comprehensive 10-week day clinic lifestyle modification program on the health condition and quality of life of CD patients. Telephone interviews (n = 19) were conducted three months after the program to examine individuals’ viewpoints on the intervention, including perceived changes and transfer of elements into daily life. Reflexive thematic analysis was performed using MAXQDA software.

Results
The results indicate that CD can have very individual and comprehensive impacts (psychological, physical, social), leading to reduced perceived quality of life and well-being. By participating in the program, patients wanted to find self-help options to complement conventional pharmacotherapy and actively manage their disease. Patients expressed high satisfaction with the program, feeling it provided valuable support for daily disease management. They were able to integrate adequate therapy elements into their routines to complement their care. Patients recognized significant improvements in various domains, mainly in the psychological domain, e.g., improved self-efficacy, symptom management, and, also partly physical/symptomatic and social improvements.

Conclusion
A multimodal stress reduction and lifestyle modification day clinic appears to be beneficial as a complementary therapy for CD patients. It offers additional options and helps patients to address individual symptoms and needs, improve their understanding of the disease and their quality of life. Although promising, further research is needed to assess its long-term effects.

Trial registration
ClinicalTrials.gov, identifier: NCT05182645.
A relação teoria-prática nos tempos da Alternância
Authors: Silva Francisca do Nascimento , Silva Paulo Roberto de Sousa 
Published: November 2024

O presente artigo propôs explicitar a relação entre teoria e prática na Pedagogia da Alternância dos Centros Familiares de Formação por Alternância (CEFFA). A construção apoiou-se teoricamente nos autores Gamboa (1995), Vázquez (2007), Gimonet (2007), Begnami (2019), Ribeiro (2010) e Caldart (2009). A sistematização foi possível a partir da pesquisa bibliográfica, que direcionou para construção do percurso das concepções da relação teoria-prática, das dicotomias idealista e pragmática à unidade dialética da práxis e na Pedagogia da Alternância dos CEFFA. A pesquisa permitiu compreender como teoria, prática e práxis são formas de comportamento humano diante da realidade, histórica e contraditória, assim como afirmar a relevância da relação entre teoria e prática na sistematização teórica da Pedagogia da Alternância dos CEFFA, potencializada, sobretudo, pelos pilares fins e meios, a partir de uma diversidade de instrumentos pedagógicos que dão vivacidade à Alternância de forma dialética.
Interação professor-aluno na pré-escola e a influência da variavel sexo da criança
Authors: Costa Luiza marivalda Barreiro da 
Published: November 2024

[...] O estudo do processo de socialização da criança tem se mostrado de grande interesse para os pesquisadores que desejam compreender o desenvolvimento do indivíduo, uma vez que nele estará embasado todo o relacionamento social do adulto. As definições do que é ser socializado são muitas, algumas mais gerais, corno a de Gardner, que diz ser a "forma através da qual a criança passa a usar os recursos sob seu comando para se relacionar efetivamente com o mundo de pessoas ou coisas", ou mais específicas, como a de Herbert, de que seria um processo complexo e longo de aprendizagem pelo qual uma criança, de início voluntariosa e centrada em si. Sabe-se que a socialização começa muito cedo na vida do indivíduo; segundo Rheingold, a criança já nasce como um organismo social, comportando-se de modo a ser responsiva, a prolongar e iniciar interação social. Portanto, a criança já vem com uma bagagem que possibilita só que adquira as normas e padrões do grupo, mas também que afete o comportamento dos adultos ao seu redor, gerando um processo bidirecional, em que cada elemento da interação provê estímulos e consequências para a do outro. [...]

Palavras-chave: Professor; Aluno; Sexo; Criança; Socialização.
O problema da justificação de teorias: do fundamento último á fundamentação provisória
Authors: Borges Bento Itamar 
Published: November 2024

[...] Uma aventura do mentiroso barão de Münchhausen sugeriu a Hans Albert uma analogia para o problema central da teoria do conhecimento, a fundamentação: Quando aspiramos ao conhecimento, "queremos formar convicções verdadeiras sobre determinados campos, setores ou partes da realidade. Embora seja um problema do conhecimento em geral, essa busca de certeza é particularmente um critério distintivo da ciência, cujas teorias, em oposição ao senso-comum, são aceitáveis e, de fato, também superiores, justamente porque a ciência, que se pretende segura e sistemática, ap6ia-se numa base que deve estar fora de qualquer suspeita. Os problemas aumentarão para aqueles que pretendem conseguir um alicerce sólido não só para seus pretensos conhecimentos, como também para convicções normativas, embora essa aspiração à certeza possa parecer óbvia ao homem comum. Para que esse princípio da fundou da razão suficiente, segundo Leibniz) seja aplicado, tem-se antes que resolver se é possível, e como, o estabelecimento de um ponto arquimédico para o pensamento, isto é, fora dele mesmo. [...]

Palavras-chave: Fundamentação; Provisória; Teoria; Münchhausen; Justificação.
Relatório do projeto de levantamento. "Aspectos da realidade do ensino aprendizagem de ciências em Uberlândia"
Authors: Carvalho Ana Maria C. 
Published: November 2024

[...] Nos meses de outubro e novembro de 1986, realizou-se um levantamento junto aos professores de ciências de 5o a 8o séries em diferentes escolas de 1o grau, com o objetivo de se analisar a situação do ensino-aprendizagem de Ciências em Uberlândia. Outros objetivos deste levantamento foram os seguintes: Propiciar ao aluno de Metodologia Específica o contato com a realidade das escolas de 1o grau; Propiciar ao aluno o aprendizado de como coletar, tabular e grafitar dados; confeccionar instrumento de pesquisa de campo, no caso, questionário. Analisar criticamente a situação do ensino de Ciências no 1o grau, levantando um perfil deste. Justifica-se este projeto porque, apesar de Ciências ser uma disciplina diretamente relacionada à vida do aluno, já que esta é a própria interpretação dos fenômenos que ocorrem na natureza e no ambiente familiar da criança, há um crescente desinteresse por esta Disciplina. Este fato pode ser comprovado através de uma análise da Feira de Ciências, na qual se constata que a participação das escolas e alunos é mínima e, mesmo quando há participação, a situação parece ser simulada, isto é, os trabalhos são preparados apenas para a ocasião, quando deveriam ser o resultado das atividades desenvolvidas na sala de aula pelos alunos. [...]

Palavras-chave: Relatório; Ciência; Uberlândia; Realidade; Projeto.
A questão indígena na sala de aula-subsídios para professores de 1º e 2º Graus
Authors: Grupioni Luis Donisete Benzi 
Published: November 2024

"No Brasil, ainda existe muitos Índios que não são civilizados, mas, em grande parte também os Índios já se comportam como todo ser humano (...) Eles tem costume de brincar de fantasma usam lençóis brancos e outros objetos com fantasia: colares e vários enfeites coloridos."
“mas os índios de antes eram muito rebeldes, não podendo ver pessoas estranhas. Agora os Índios já bem desenvolvido e bem calmos” "O Juruna é que comanda tudo, se o Juruna manda eles matar alguém, eles matam. Todo mundo pensa que Índio é mau, na verdade eles bem mais civilizados que nos brasileiros. A não ser o fruo africano, esses são fogo na roupa, se marca eles até te come."
“Os índios antigamente eram super diferentes, falavam uma língua totalmente diferente. Eles não dormiam de dia e noite batucando. Os homens eram pintados, usavam brincos e colares." Estes são trechos de redações elaboradas por alguns alunos de uma escola da rede estadual de ensino, na periferia de Paulo. A pedido professor, alunos da 6a série 1 escreveram sobre "Os índios brasileiros". Os trechos falam por si só: estere6tipo e preconceito. “ [...]

Palavras-chave: Brasil; Civilização; Índios; Homens; Crianças.
Von „Weinbergfrauen“ zu migrantischer Saisonarbeit
Authors: Kädtler Jürgen , Kottwitz Gisela 
Published: November 2024

Zusammenfassung
Der Beitrag präsentiert Ergebnisse einer qualitativen empirischen Studie zu in der Regel migrantischer Saisonarbeit im deutschen (Hoch-) Qualitätsweinbau. Migrantische Saisonbeschäftigte sind seit den 1990er Jahren an die Stelle vormaliger Stammbelegschaften aus „Zuverdienerinnen“ auf Aushilfebasis getreten. Im Gegensatz zur verbreiteten Qualifizierung landwirtschaftlicher Saisonarbeit als Einfacharbeit wird die These vertreten, dass das untersuchte Segment durch Qualifikationsaufbau und Anlernkarrieren im Sinne des segmentationstheoretischen Konzepts interner Arbeitsmärkte charakterisiert ist. Und es werden Bedingungen einer entsprechenden Stammbelegschaftspolitik auf Migrationsbasis analysiert.
Wettererscheinungen in Märchen, Sagen und anderen Volkserzählungen
Authors: Uther Hans-Jörg 
Published: November 2024

Abstract
We hear weather reports every day and, in a digitally networked world, learn in real time here and how catastrophic damage causes weather upheavals. The universal significance of the weather for humans, animals and the environment is reflected in different ways in European folk tales. Popular beliefs often play a role in this. This article is intended as an overview of the most important phenomena.