bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circuito Quilombola (Eldorado-SP):	possibilidades para o turismo cultural
Authors: Souza Silvana Do rocio de 
Published: September 2019

Resumo: Os remanescentes de quilombos possuem um vasto patrimônio cultural. Este pode ser fortalecido por meio da atividade turística. Na região do Vale do Ribeira (SP) está localizado o município de Eldorado, que possui um número significativo de comunidades quilombolas em seu território. Este artigo buscou analisar o turismo em seis destas comunidades (André Lopes, Ivaporunduva, Pedro Cubas, Pedro Cubas de Cima, São Pedro e Sapatú) e a relação da atividade com o fortalecimento de seus patrimônios culturais, por meio do Circuito Quilombola do Vale do Ribeira. Como metodologia utilizou-se da pesquisa bibliográfica e documental especialmente através do Inventário Cultural de Quilombos do Vale do Ribeira, acompanhada de roteiro de observação em campo. Por essa análise constatou–se que as comunidades possuem um patrimônio cultural que vai muito além do atualmente oferecido pelo circuito e que um trabalho conjunto entre pode público, iniciativa privada e terceiro setor podem auxiliar o planejamento e fomentar a vinda de visitantes, o que consequentemente fará com que os tradicionais quilombolas continuem atuando para a preservação do seu rico patrimônio cultural.
Estudo Comparativo entre Brasil e Portugal da Política de Proteção Infanto-juvenil
Authors: Lírio Flávio Corsini , Bonito Jorge 
Published: September 2019

O texto apresenta uma reflexão da política de proteção infanto-juvenil no Brasil e em Portugal. Em ambos os países se verifica uma preocupação voltada ao cuidado dessa população nas últimas décadas, por meio da mudança de paradigma quanto ao tratamento e o modus operante. A pesquisa é qualitativa e o método de investigação com análise bibliográfica, documental e entrevista semiestruturada. Verifica-se que Brasil e Portugal possuem respectivamente legislação específica como, por exemplo, o Estatuto da Criança e do Adolescente e a Lei de Proteção de Crianças e Jovens em Perigo. Essas leis em ambos os países regulamentam o financiamento das ações de proteção social de crianças e jovens. Também são signatários da Convenção da Criança editada pela Organização das Nações Unidas em 1989. A análise apresenta que há limitações e questionamentos ao modelo social de aplicação dessa política em Portugal e no Brasil.
A política de Assistência Social e o enfrentamento à violência sexual infanto-juvenil
Authors: Vieira Monique Soares , Grossi Patrícia Krieger 
Published: September 2019

O presente artigo tem como objetivo analisar, a partir da realidade do Estado do Tocantins, como a Política de Assistência Social, por meio das ações dos Centros de Referência Especializado de Assistência Social (CREAS), vem se configurando para a promoção dos direitos das crianças, adolescentes e suas famílias em situação de violência sexual. Para a coleta de dados, realizaram-se 17 entrevistas com famílias, profissionais e coordenadores/as de 5 CREAS e os dados foram submetidos à análise de conteúdo. Os resultados revelam a presença de valores calcados em uma cultura baseada na desigualdade socioeconômica, de gênero e geração bem como os impactos da precarização das políticas sociais nos processos interventivos dos profissionais junto a essa expressão da violência. Conclui-se que a construção da integralidade do atendimento às crianças, adolescentes e famílias em situação de violência sexual requer um movimento que promova o rompimento com respostas revitimizantes.
Sero-Detection of Leptospira hardjo in Cattle of Bhaktapur District of Nepal
Authors: Rawal Gaurav , Shrestha Denusha 
Published: September 2019

Leptospira hardjo is the most commonly reported cause of leptospirosis among cattle globally. The objective of this study was to determine sero-detection of Leptospira hardjo in cattle of Bhaktapur district of Nepal. A cross-sectional study was conducted in cattle pockets located at 4 different village development committees (VDCs) in the Bhaktapur district of Nepal. The sample collection was done in cattle to determine the sero-detection of Leptospira hardjo from February 2014 to June 2014. A total of 176 serum samples were collected from four VDCs of Bhaktapur district namely Sipadol, Dhadikot, Duwakot and Nangkhel, selected purposively. Forty samples from Sipadol, 46 Dhadikot, 42 Duwakot and 48 from Nangkhel were collected. 5 ml of blood was collected aseptically from jugular vein using 5 ml sterile disposable syringe. After that blood was transferred to the plain vacutainer. The harvested sera were transferred to serum vials and stored at in -20˚c deep freeze of Central Veterinary Laboratory until used for ELISA test. For screening of Leptospira hardjo, the Leptospira hardjo antibody test kit, ELISA (Prionics, Netherlands) was used. ANOVA along with multiple comparison test Tukey was used to compare frequency of detection across different locations in Bhaktapur district using SAS 9.4. MS-Excel was used to manage ELISA data from four different VDCs and to extract information regarding frequency of detection. There was 5.11% sero-detection in cattle of Bhaktapur district. Location wise sero-detection was 5% in Sipadol, 4.3% in Dhadikot, 4.76% in Duwakot and 6.25% in Nangkhel. The study showed that the detection of Leptospira hardjo in cattle. There was no statistical difference (P>0.05) between location suggesting that cattle in all areas are equally at risk of this pathogen. Further study is suggested on isolation and identification of disease in Nepal.
Int. J. Appl. Sci. Biotechnol. Vol 7(3): 378-381
PENGARUH QUICK RATIO, DER, DAN WORKING CAPITAL TURNOVER TERHADAP PERTUMBUHAN LABA PT WIJAYA KARYA TBKTAHUN 2007 – 2017
Authors: Permada Dewi Nari Ratih 
Published: September 2019

Tujuan penelitian ini adalah mengetahu pengaruh quick ratio, debt to equity ratio dan working capital turnover terhadap pertumbuhan laba PT Wijaya Karya Tbk periode tahun 2007 sampai dengan tahun 2017. Metode penelitian yang digunakan adalah metode kuantitatif dengan pendekatan deskriptif. Hasil penelitian Tidak terdapat pengaruh yang signifikan antara variabel quick ratio (X1) terhadap pertumbuhan laba (Y) dengan koefisien korelasi sebesar 1,098 atau (rx1y=1,098). Tidak terdapat pengaruh yang signifikan antara variabel debt to equity ratio (X2) terhadap pertumbuhan laba (Y) dengan koefisien korelasi sebesar 0,065 atau (rx2y=0,065). Tidak terdapat pengaruh yang signifikan antara variabel working capital turnover (X3) terhadap pertumbuhan laba (Y) dengan koefisien korelasi sebesar 0,025 atau (rx3y=0,025). Tidak terdapat pengaruh yang signifikan antara variabel quick ratio (X1), debt to equity ratio (X2), dan working capital turnover (X3) secara simultan terhadap pertumbuhan laba (Y) dengan persamaan Y = -1,348 + 1,098 X1 + 0,065 X2 + 0,025 X3. Nilai koefisien determinasi adalah sebesar 0,179. Nilai ini menjelaskan bahwa pengaruh vairable quick ratio (X1), debt to equity ratio (X2)dan working capital turnover (X3) berpengaruh 17,9% terhadap pertumbuhan laba (Y) sedangkan 82,1% dipengaruhi oleh variabel lain. Dengan kata lain pengaruh ke tiga variabel bebas sangat lemah terhadap variabel terikatnya
ANALISA HUBUNGAN STATUS GIZI DAN RIWAYAT PENYAKIT DENGAN KELELAHAN KERJA DI PT X
Authors: AMALIA IZZA 
Published: September 2019

Fatigue can lead to a decrease in productivity and increase the incidence of workplace accidents. The purpose of this study was to analyze the relationship between nutritional status and history of disease with work fatigue in workers at PT. X. This study was an observational study using a cross-sectional approach. The sample of this study was the total population of 45 workers from the morning shift workers. The independent variables of this study were nutritional status and disease history. The dependent variable was work fatigue. Coefficient correlation is used as data analysis to determine the strength of the relationship of the variables. The results showed that some workers’ nutritional status was fat (57.8%), and as much as (26.7%) workers had history of a certain disease. The conclusion of this study is both nutritional status and history of disease have a moderate relationship with work fatigue in workers of morning shift at PT.X. A monitoring of nutritional status from the companies is needed to be done for the workers also regularly holding a physical activity or exercise every once a week and conducting regular health checks can be done to maintain the good condition of the workers.
Keywords : Fatigue, Nutritional Status, Medical of Disease
Factors Influencing Development of Depressive Illness among Parkinson’s Disease Patients
Authors: Sarkar Provat Kumar , Rahman Hasan Zahidur , Chandra Mahua , Ahmed Anis , Islam Md Enayet Ul , Shaikh Abdul Kader , Zahid Rashed Imam , Mondal Gurudas , Nayeem Abu , Momin Afzal 
Published: September 2019

Background: Depressive illness is present among Parkinson’s disease (PD) patients.
Objective: The purpose of the present study was to see the influencing factors of development of depressive illness among Parkinson’s disease patients.
Methodology: This comparative cross-sectional study was carried out in the Department of Neurology and Department of Psychiatry at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from July 2009 to June 2011 for a period of two (2) years. Parkinson’s disease patients who were attended at the movement disorder clinic and general OPD of Department of Neurology and in-patient department of Neurology at BSMMU, Dhaka were selected as study population. Patients with Parkinson’s plus syndrome, with dementia or other causes of parkinsonism like vascular or drug induced parkinsonism were excluded from this study. Data were collected by filling structured clinical questionnaire, then filling up of ‘structured clinical interview for DSM-IV Axis I disorders’ (SCID-CV) and self-reported ‘Depression scale` questionnaire. Parkinson disease was diagnosed by neurologist by the presence of two or more of the four cardinal criteria namely tremor, rigidity, bradykinesia and postural instability. Then patients were screened for depression by a psychiatrist of Department of Psychiatry at BSMMU, Dhaka.
Result: A total of 100 Parkinson’s disease patients were interviewed and 80 patients ultimately participated in the study. The mean age of total Parkinson’s disease patients was 57.71±12.36 years ranging from 35 to 82 years with highest percentage (35%) had age group 65 years or above, 28.7% in 55 to 64 years, 22.5% in 45 to 54 years and lowest percentage (13.8%) in age group less than 45 years. Among 80 Parkinson’s disease patients, depression was present in 34 (42%) patients and was absent in 46 (58%) patients. Diabetes mellitus (p=0.125), hypertension (p=0.097), hypothyroidism (p=1.000), other illness (p=0.595), family history of PD (p=0.758) and levodopa use (p=0.661) were not significantly associated with the development of depressive illness in Parkinson’s disease.
Conclusion: Diabetes mellitus (DM), hypertension (HTN), hypothyroidism, other illness, family history of PD and levodopa use do not significantly influence in the development of depressive illness among the Parkinson’s disease.
Journal of National Institute of Neurosciences Bangladesh, 2019;5(2): 106-110
MANFAAT SERTA KENDALA MENERAPKAN FLASHCARD PADA PELAJARAN MEMBACA PERMULAAN
Authors: Munthe Ashiong P. , Sitinjak Jesica Vitasari 
Published: September 2019

ABSTRACT

The beginning reading is the initial stage of reading learning that must be taught from an early age, because it is the basis for students to be able to move to the reading comprehension stage. In the reading beginning, students are taught to recognize letters and letter sounds, stringing letters into syllables, words to compose sentences. When implementing the reading beginning with flashcard there are certainly benefits and constraints encountered. Thus, this research was conducted to describe the benefits and constraints encountered when applying a flascard to the beginning reading learning. The research method used is qualitative descriptive. Qualitative descriptive is an effort to explain facts, data, or objects, qualitatively in the form of language or discourse by interpreting appropriately and systematically. Data is displayed not in the form of quantitative numbers. This research was conducted in one of the private schools in Mamit, Papua. The class observed was grade 1 elementary school. The benefits of applying flashcard to the beginning reading learning is able to attract students' attention, students are not nervous while reading, and help students remember words more easily. While the constraints in implementing flashcards is that it takes a long time.

Keywords: Flashcard, Reading, The Beginning Reading

ABSTRAK

Membaca permulaan merupakan tahap awal dari pembelajaran membaca yang harus diajarkan sejak usia dini, karena hal tersebut merupakan dasar bagi siswa untuk dapat melangkah kepada tahap membaca pemahaman. Saat membaca permulaan, siswa diajarkan untuk mengenal huruf dan bunyi huruf, merangkai huruf menjadi suku kata, kata hingga menyusun kalimat. Saat menerapkan membaca permulaan dengan flashcard tentunya ada manfaat dan kendala yang ditemui. Dengan demikian, penelitian ini diadakan untuk menguraikan manfaat dan kendala yang ditemui saat menerapkan flascard pada pembelajarana membaca permulaan. Metode penelitian yang digunakan adalah deskriptif kualitatif.

Deskriptif kualitatif adalah upaya menjelaskan fakta, data, atau objek, secara kualitatif dalam bentuk bahasa atau wacana dengan menginterpretasi secara tepat dan sistematis. Data ditampilkan bukan berupa angka-angka kuantitatif. Penelitian ini dilakukan di salah satu sekolah swasta yang ada di Mamit, Papua. Kelas yang di observasi adalah kelas 1 Sekolah Dasar. Manfaat dari penerapan flashcard pada pembelajaran membaca Permulaan adalah mampu menarik perhatian siswa, siswa tidak gugup ketika membaca, dan membantu siswa lebih mudah mengingat kata. Sedangkan kendala dalam penerapan flashcard adalah membutuhkan waktu yang lama.

Kata Kunci: Flashcard, Membaca, Membaca Permulaan
Vicdan Algısı Ölçeği’ nin Türkçe Geçerlilik Güvenilirliği
Authors: AKSOY Sena Dilek , MERT Kader , ÇETİN İbrahim 
Published: September 2019

Amaç: Zihinsel
bir süreç olan vicdan, özel ve mesleki yaşamda tutum ve davranışlara etki eden,
felsefi, etik ve ahlaki yönü bulunan çok boyutlu bir kavramdır. Hemşirelerin
çalışma hayatlarında hissettikleri vicdani rahatsızlık, ilerleyen süreçte suçluluk,
hüzün, umutsuzluk ve güçsüzlük gibi olumsuz duygular yaşamalarına ve mesleki
tükenmişliklerine sebep olabilir.

Yöntem: Bu araştırma
metodolojik bir araştırma olup, 163 hemşire ile yapılmıştır. Verilerin toplanmasında tanıtıcı bilgi formu
ve Dahlqvist ve arkadaşları tarafından geliştirilen vicdan algısı ölçeği
kullanılmıştır. Ölçeğin dil uyarlaması ve içerik geçerlilik incelemesinin
değerlendirilmesinin ardından veriler, kapsam geçerlilik için uzmanlar arası
uyum bakımından değerlendirilmiştir. Yapı geçerliliği için ise faktör analizi
yapılmıştır. Güvenilirlik çalışması, madde toplam korelasyonu, Cronbach alfa
katsayıları ve test tekrar test ile incelenmiştir.

Bulgular: Ölçeğin kapsam geçerliliği değerlendirme puanları
bakımından uzman görüşleri arasında uyum saptanmıştır (Kendall’s W=0,114; p=0,101
&gt; 0,05). Ölçeğin madde-toplam puan korelasyon katsayıları (r) 0,090 – 0,697
arasında olduğu ve aralarındaki ilişkinin pozitif yönde istatistiksel yönden
ileri düzeyde anlamlı olduğu (p &lt; 0,001) bulunmuştur. Güvenirlik
analizlerinde Cronbach Alpha katsayısı 0,84 ve test tekrar test korelasyon
katsayısı r=0,97’dir.Sonuç: İstatistiksel
değerlendirmede, 16 maddeli ölçeğin 3 maddesinin ölçekten çıkartılarak, 13
maddeli haliyle Türkiye’deki hemşirelerle ilgili yapılacak çalışmalarda
kullanılması uygun bulunmuştur.
Pengaruh Kombinasi Vitamin C dan D Dosis Tinggi Terhadap System Hemopoetik Penderita Kanker Kepala Leher yang Mendapat Kemoterapi Cisplatin
Authors: Aminullah Yusuf , - Wiratno , Susilaningsih Neni 
Published: September 2019

Latar belakang : Cisplatin dapat menyebabkan penurunan sistem hemopoetik akibat Radical oxygen spesies (ROS) pada penderita kanker kepala dan leher (KKL). Kombinasi vitamin C dan E dosis tinggi sebagai antioksidan dari luar diperlukan untuk menetralisir ROS. Tujuan penelitian ini adalah membuktikan bahwa kombinasi vitamin C dan E dosis tinggi dapat mengurangi penurunan sistem hemopoetik penderita KKL akibat cisplatin.
Metode : Penelitian eksperimental pre-post test design. Subyek yang memenuhi kriteria inklusi dari klinik dan bangsal THT-KL RSUP Dr. Kariadi Semarang dilakukan randomisasi blok, kemudian dibagi menjadi dua kelompok; kelompok perlakuan diberikan kombinasi vitamin C 1000 mg dan E 400 mg dan kelompok kontrol diberikan vitamin C 2x50 mg selama 5 minggu. Analisis data dengan chi square, paired t-test dan independent t-test.
Hasil : Empat puluh delapan subyek memenuhi kriteria inklusi, usia terbanyak 50–59 tahun yaitu 35,6%, laki-laki dan perempuan 3 : 1, KNF 32(71,1%), stadium IV 27(60%). Terdapat penurunan hemoglobin dan lekosit yang bermakna antara kedua kelompok (p<0,05), sedangkan penurunan eritrosit dan trombosit tidak berbeda bermakna (p>0,05)
Simpulan : Kombinasi vitamin C dan E dosis tinggi dapat mengurangi penurunan kadar hemoglobin dan jumlah lekosit penderita KKL akibat cisplatin.
Kata kunci: Kombinasi vitamin C dan E dosis tinggi, cisplatin, sistem hemopoetik.
Aspek Biomolekuler Apoptosis, Caspase-3 & RAK pada Pemberian Morinda Citrifolia L (Mengkudu) Tikus Sprague Dawley Diabetes Nefropati yang Diinduksi Streptocotocin (STZ)
Authors: KS Indranila 
Published: September 2019

Latar belakang : Nefropati diabetes (ND) adalah salah satu bentuk komplikasi mikrovaskuler yang sering dijumpai pada penderita diabetes mellitus (DM). Morinda citrifolia L (Mengkudu) memiliki komponen zat bioaktif bersifat imunomodulator, imunosupresif, anti inflamasi dan antiapoptosis, diharapkan dapat memperbaiki fungsi ginjal dengan pengukuran biomarker RAK, indeks apoptosis, dan caspase-3.
Tujuan penelitian : Membuktikan peran Morinda citrifolia L(MC) dalam memperbaiki fungsi ginjal ND pada tikus SD yang diinduksi STZ.
Metode penelitian :The post test only control group desain. Tiga puluh enam ekor tikus Sprague Dawley dibagi menjadi 6 kelompok : 2 kelompok kontrol, dan 4 kelompok perlakuan. Tikus diinduksi STZ dosisi 40 mg/kgBB selama 8 minggu, kemudian di beri MC dosis 10,20,40,80mg/dL selama 2 minggu. Pada akhir penelitian tikus diperiksa RAK, indeks apoptosis, caspase-3. Data dianalisis menggunakan Mann Whitney dan regresi linier berganda. dengan tingkat kemaknaan p<0,05.
Hasil dan pembahasan :Pada penelitian ini digunakan 36 ekor tikus SD yang dikelompokkan menjadi 6 kelompok yaitu kelompok 1 mendapat kelompok STZ + MC 10 mg, 1 kelompok mendapat kelompok STZ + MC 20 mg,1 kelompok STZ + MC 40 mg, 1kelompok STZ + MC 80 mg,1 kelompok STZ / kontrol (+ ) dan 1 kelompok kelompok kontrol (-). Hasil uji statistik menunjukkan RAK urin kelompok MC 20 mg adalah lebih rendah secara bermakna dibanding kelompok kontrol (+) dengan nilai p=0,04. Indeks apoptosis kelompok MC 20 mg adalah lebih rendah secara bermakna dibanding kontrol (+) dengan p=0,002. Ekspresi caspase-3 jaringan glomerulus yang tertinggi adalah pada kelompok yang mendapat STZ dan MC yang paling rendah adalah pada kelompok yang mendapat MC 20 mg. Korelasi antara ekspresi caspase-3 dengan indeks apoptosis pada jaringan glomerulus dan tubulus ginjal menunjukkan adanya korelasi positip kuat (p<0,001) Hal ini secara tidak langsung dapat menjelaskan apotosis yang terjadi pada jaringan nefron ginjal adalah melalui jalur caspase.
Simpulan dan saran : Pemberian Morinda citrifolia L dosis 10,20,40,80mg/dL dapat menurunkan status albuminuri berdasarkan pengukuran RAK, indeks apoptosis glomerulus, ekspresi caspase-3. Pemberian ekstrak Morinda citrifolia L dapat memperbaiki fungsi ginjal paling bermakna pada konsentrasi 20 mg/dL,dan berpengaruh paling kuat untuk perbaikan ND melalui apoptosis glomerulus terhadap penurunan status albuminuria (RAK).Perlu dilakukan penelitian lanjutan pada manusia, dengan dosis 100mg/kgBB, yang merupakan hasil konversi dosis 20mg/dL pada tikus.
Kata kunci : nefropati diabetes, morinda citrifolia L, tikus SD, STZ, apoptosis, caspase-3, RAK
Karakteristik Pasien HIV/AIDS dengan Kandidiasis Orofaringeal di RSUP Dr . Kariadi Semarang
Authors: Sofro Muchlis , Angita Innes , Isbandrio Bambang 
Published: September 2019

Latar belakang : Epidemi HIV/AIDS di Indonesia merupakan salah satu yang paling cepat di Asia. Penelitian di RSUP Dr. Kariadi Semarang menunjukkan bahwa infeksi oportunistik yang tersering pada pasien HIV/AIDS adalah kandidiasis orofaringeal sebesar 79%. Kandidiasis orofaringeal merupakan infeksi oportunistik mukosa yang banyak disebabkan oleh jamur Candida albicans, tetapi dapat disebabkan oleh spesies lain seperti Candida glabrata, Candida tropicalis dan Candida krusei. Tujuan penelitian adalah mengetahui karakteristik dan jenis kandida pasien HIV/AIDS dengan kandidiasis orofaringeal di RSUP Dr. Kariadi Semarang.
Metode : Penelitian deskriptif observasional pada pasien HIV/AIDS dengan kandidiasis orofaringeal yang dirawat di Bangsal Penyakit Dalam RSUP Dr. Kariadi Semarang pada Desember 2010–Mei 2011. Kriteria diagnosis melalui identifikasi mikrobiologi (pengecatan gram, kultur, germ tube dan fermentasi)
Hasil : Total 42 Pasien HIV/AIDS dengan kandidiasis orofaringeal terdapat 29 laki-laki (69%), rentang usia terbanyak 30–39 tahun, pekerjaan buruh dan pegawai swasta (21,43%), pasien sudah menikah (88,09%), underweight (52,38%), berasal dari Semarang (33,33%), CD4 <50 sel/µl (78,57%). Hasil kultur mikrobiologi 40 sampel tumbuh koloni kandida, 75% tumbuh >300 koloni kandida, jenis spesies kandida 55% non C. albicans yang terdiri dari C. stellatoidea 15%, C. tropicalis 15%, C. parapsilosis 12,5%, C. krusei 7,5%, C. glabrata 2,5%, C. guilliermondia 2,5%.
Simpulan : Pasien HIV/AIDS yang menderita kandidiasis orofaringeal sebagian besar mempunyai CD4 <50 sel/µl, didapatkan koloni kandida pada kultur mikrobiologi dengan 55% diantaranya jenis non C. albicans.
Kata kunci : Kandidiasis orofaringeal, HIV/AIDS
Pengaruh Pemberian Monosodium Glutamat peroral terhadap Degenerasi Neuron Piramidal CA1 Hipokampus pada Tikus Wistar
Authors: Simon Halomoan , Muhartomo Hexanto , Pudjonarko Dwi 
Published: September 2019

Latar belakang : Monosodium glutamat (MSG) adalah garam sodium dari asam amino asam glutamat digunakan luas di masyarakat sebagai penyedap rasa. Pemakaian MSG dalam dosis tepat relatif aman. Penggunaan MSG dalam dosis tinggi dan berlangsung lama menyebabkan gangguan neuroendokrin dan degenerasi neuron, sehingga muncul pertanyaan seberapa jauh MSG peroral berpengaruh terhadap degenerasi neuron piramidal di regio CA1 hipokampus. Tujuan penelitian ini adalah membuktikan pengaruh pemberian MSG peroral terhadap degenerasi neuron piramidal di regio CA1 hipokampus pada tikus Wistar.
Metode: Penelitian eksperimental laboratorik dengan 30 tikus Wistar jantan usia 8 minggu, berat 200 gram dibagi menjadi 5 kelompok (1 kelompok kontrol, 4 kelompok perlakuan) diberikan MSG secara oral dosis 5 mg/grBB/hr dan 10 mg/grBB/hr selama 4 minggu. Setelah 2 minggu dan 4 minggu perlakuan dilakukan pemeriksaan patologi anatomi di jaringan hipokampus dan rerata jumlah sel piramidal yang berdegenerasi pada CA1 hipokampus dianalisa dengan Uji ANOVA dilanjutkan Post Hoc, Kruskal Wallis Test dilanjutkan Mann-Whitney Test, uji Paired T-Test dan Wilcoxon Signed Ranks Test. Analisa data menggunakan program SPSS versi 17.0.
Hasil: Ada perbedaan bermakna pada rerata jumlah neuron piramidal yang berdegenerasi di regio CA1 hipokampus antara kelompok penelitian setelah 2 minggu dan 4 minggu perlakuan (p=0,0001).
Simpulan: Pemberian MSG per oral dosis 5 mg/grBB/hr dan
10 mg/grBB/hr selama 2 minggu dan 4 minggu terbukti berpengaruh terhadap rerata jumlah neuron piramidal yang berdegenerasi di region CA1 hipokampus tikus Wistar.
Kata kunci: Monosodium glutamat, degenerasi neuron piramidal CA1 hipokampus.