bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desmoid Tumor of the Rectus Abdominis Muscle in a 2-Year-Old Boy
Authors: Jonuzi Asmir , Zvizdic Zlatan , Popovic Nusret , Milisic Emir , Karamustafic Azra , Mesic Amira , Sefić Irmina , Džananović Amra 
Published: June 2018

Aggressive fibromatosis, also known as desmoid tumor, is a locally invasive soft tissue lesion arising from connective tissues. Reports in children less than 10 years of age is rare. We report a case of a desmoid tumor located at the middle and lower third of the left rectus abdominis, in a 2-year-old-boy. Partial resection of the muscle segment and simultaneous reconstruction of the abdominal wall by abdominal fascia was done. The patient had an uneventful recovery. At one year of follow-up neither recurrence nor functional or aesthetic complications were seen.
An Unprecedented Cyano-Induced Sodium Nitrite-Catalyzed C(sp3)-H and C(sp2)-H Coupling Reaction
Authors: Li Ling , Su Bo , Liu Yuxiu , Wang Qingmin 
Published: June 2018

Aim and Objective: During the investigation of sodium nitrite-catalyzed oxidative coupling reaction
of aryls, an unprecedented C(sp2)-H and C(sp3)-H coupling of substituted 2-aryl acetonitrile was found.

Materials and Methods:

The structure of the coupled product was confirmed by 1H and 13C NMR spectroscopy
and high-resolution mass spectrometry (HRMS), and comparison of its derivatives with known compounds.
The effects of methoxy group in the benzene ring on the reaction were evaluated.

Results:
The optimized reaction conditions are summarized as follows: CF3SO3H/substrate = 1.5 equiv.,
NaNO2/substrate = 0.3 equiv., CH3CN as solvent. 2-(4-Methoxyphenyl)acetonitrile and 2-(3,4,5-
trimethoxyphenyl)acetonitrile could also generate C(sp2)-H and C(sp3)-H coupling. The coupling reaction occurred
as a typical radial mechanism.

Conclusion:
An unprecedented cyano-induced, NaNO2-catalyzed oxidative C(sp3)-H and C(sp2)-H coupling
was reported. The reaction proceeded under very mild conditions, using O2 in the air as terminal oxidant. The
unique oxidative manner might provide more inspiration for the development of intriguing oxidative coupling
reactions.
Quantitative Evaluation of Diabetic Medical Record Documentation
Authors: Khorasani Zahra Mazloum , Tara Mahmood , Ebnehoseini Zahra , Etminani Kobra , Moosavi Zohreh 
Published: June 2018

Background:
The documentation of medical records of diabetic patients is very important
for the treatment of diabetes. The purpose of this study was to conduct quantitative evaluations of the
Diabetic Medical Record (DMR) and Documentation Completeness Rate (DCR).

Methods:
In this retrospective study, we evaluated the DCR of DMRs in the Comprehensive Diabetes
Center of Imam Reza Hospital (CDRIRH). A checklist was prepared to evaluate the DCR. The overall
assessment of the DCR was represented according to the following rating: 95–100% as strong, 75–94%
as moderate, and less than 75% as weak. The free texts that physicians recorded in the DMRs were extracted
to identify the data elements that physicians must record. In addition, the clinical importance of
the data elements of the DMRs from the perspective of the endocrinologists was determined and then
compared with the DCR.

Results:
In this study, 1,200 DMRs and DCRs for 50 data elements in eight major categories were
evaluated. The total DCR average was 30% and data elements in the laboratory test results category
demonstrated the highest DCR (50.5%), whereas the least percentage was demonstrated in the internal
visits category. The DCR for the other main categories was: demographic information = 48.5%; patient
referral information = 14.2%; diagnosis = 5%; anti-hyperglycemic medications = 25.5%; diabetic complications
= 17.7%; and results of specialty and subspecialty consultation = 41.7%. The evaluation of
the free text data element in the DMRs indicated that physicians documented free text data elements in
three categories.

Conclusion:
Our results demonstrated a weak level of documentation in the DMRs. The physicians had
written many data elements in the margins of the DMRs. Therefore, it indicates the necessity to modify
and change the structure of the DMR.
A Novel Combination of ω-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-reactive Protein Serum Levels in Patients with Migraine: A Randomized Clinical Trial Study
Authors: Abdolahi Mina , Sarraf Payam , Javanbakht Mohammad Hassan , Honarvar Niyaz Mohammadzadeh , Hatami Mahsa , Soveyd Neda , Tafakhori Abbas , Sedighiyan Mohsen , Djalali Mona , Jafarieh Arash , Masoudian Yousef , Djalali Mahmoud 
Published: June 2018

Background:
Migraine is a disabling neuroinflammatory condition characterized by increasing
the levels of interleukin (IL)-6, a proinflammatory cytokine and C-reactive protein (CRP)
which considered as a vascular inflammatory mediator, disrupting the integrity of blood-brain barrier
and contributing to neurogenic inflammation, and disease progression. Curcumin and ω-3 fatty acids
can exert neuroprotective effects through modulation of IL-6 gene expression and CRP levels. The aim
of present study is the evaluation of combined effects of ω-3 fatty acids and nano-curcumin supplementation
on IL-6 gene expression and serum level and hs-CRP levels in migraine patients.

Methods:
Eighty episodic migraine patients enrolled in the trial and were divided into four groups as 1)
combination of ω-3 fatty acids (2500 mg) plus nano-curcumin (80 mg), 2) ω-3 (2500 mg), 3) nanocurcumin
(80 mg), and 4) the control (ω-3 and nano-curcumin placebo included oral paraffin oil) over
a two-month period. At the beginning and the end of the study, the expression of IL-6 from peripheral
blood mononuclear cells and IL-6 and hs-CRP serum levels were measured, using a real-time PCR and
ELISA methods, respectively.

Results:
The results showed that both of ω-3 and nano-curcumin down-regulated IL-6 mRAN and significantly
decreased the serum concentration. hs-CRP serum levels significantly decrease in combination
and nano-curcumin within groups (P<0.05). An additive greater reduction of IL-6 and hs-CRP
was observed in the combination group suggested a possible synergetic relation.

Conclusion:
It seems that ω-3 fatty acids and curcumin supplementation can be considered a new
promising target in migraine prevention.
Comparison of Total Hip Arthroplasty Outcomes after Failed Femoral Wedge or Curved Varus Osteotomy
Authors: Sonohata Motoki , Kitajima Masaru , Kawano Shunsuke , Mawatari Masaaki 
Published: June 2018

Background:
Differences in clinical and radiographic results following total hip arthroplasty between failed wedge and curved varus osteotomy are unclear.

Objective:
To investigate differences in clinical and radiographic results following total hip arthroplasty in patients who exhibited failed wedge or curved varus osteotomy.

Method:
We performed 18 total hip arthroplasties after failed femoral varus osteotomy. Hips were divided into two groups: 14 had failed wedge varus osteotomy and four had failed curved varus osteotomy. Average ages at osteotomy and total hip arthroplasty were 27 years old (range, 10-46 years old) and 56 years old (range, 25-74 years old), respectively. The average duration of follow-up monitoring was 72.2 months (range, 54-91 months). Clinical and radiographic evaluations were completed for each group.

Results:
The Japanese Orthopaedic Association hip score of total hip arthroplasty after failed varus osteotomy significantly improved at the last follow-up in both groups. However, hip score at the last follow-up was significantly higher after failed curved varus osteotomy than after failed wedge varus osteotomy (p<0.01). Four hips that failed wedge varus osteotomy underwent subtrochanteric corrective osteotomy with total hip arthroplasty. Radiographic evaluation showed that three stems for total hip arthroplasty after failed wedge varus osteotomy were inserted in malposition, and all stems in total hip arthroplasty after failed curved varus osteotomy were inserted in the normal position.

Conclusion:
Surgeons performing femoral varus osteotomy should consider possible future conversion to total hip arthroplasty. Curved varus osteotomy is more suitable than wedge varus osteotomy for future conversion to total hip arthroplasty.
Evaluation of the Percolation Sensitivity of Loose Sandstone Using Digital Core Technology
Authors: Pang Jin , Li Junnan , Liang Jie , Wang XiaoLu , Kui Mingqing 
Published: June 2018

Background:The integrity of the extracted core in loose sandstone gas reservoirs is poor, and because hydration and collapse easily occur, it is difficult to evaluate the sensitivity characteristics accurately by the traditional core flooding experiments.Objectives:We instead investigate the stress sensitivity and water sensitivity of the formation water soaking time using digital core technology.Methods:We take the core of a loose sandstone gas reservoir as a research object and begin by scanning the core samples with a CT scanner. A three-dimensional image of the core can be obtained, the digital information extracted, the pore structure of the porous media mapped directly to the network, and a digital core established using the principles of fractal geometry. The three-dimensional pore network model can also be extracted. Next, we can compare and correct the results calculated by the model based on the real core experimental results, and an objective and effective digital core model can be obtained.Results and Conclusion:Finally, we can calculate the different effective stress, pore throat parameters (pore throat radius, shape factor, coordination number, pore-throat ratio) and relative permeability of different formation water injury times. The research results demonstrate that in sandstone gas reservoir development, as the effective stress continuously increases, the rock pore-throat parameters continue to decrease, and the permeability of the reservoir rock ultimately declines by more than 43.2%. Clay minerals will expand after the edge and bottom water intrude into the reservoir and soak it for a long time: the pore throat is significantly narrowed within 30 days, while after 30 days more, the pore throat undergoes any only slight further changes, and the final permeability decline of the reservoir rock is up to 5.7%. The research results provide important basic petrophysical data for the development of loose sandstone gas reservoirs which, in turn, provide a scientific basis for formulating a reasonable gas production rate in a gas reservoir.
ELAZIĞ KENTİ İÇİN ARKEOPARK ÖNERİSİ
Authors: ASLAN Fürüzan , ATEŞ Oğuz 
Published: June 2018

Öz: Amaç: Bu çalışmada arkeolojik sit alanlarının odak noktası
haline getirilebilmesi için peyzaj tasarımı aracılığıyla tanıtımının yapılması,
arkeolojik alanlarda peyzaj kavramının oluşturulması amaçlanmıştır. Yöntem: Yöntem aşaması; verilerin
toplanması, analiz, verilerin çözüm ve yorumlanması başlıkları altında
incelenmiştir. Veri toplama aşamasında; çalışma alanında yapılan gözlemler,
yetkililerle yapılan görüşmeler, çalışma alanı fotoğraf çekimleri ve kurum
kuruluşlardan elde edilen veriler elde edilmiştir. Analiz aşamasında; Veri
analizleri ve gztf analizleri yapılmıştır. Verilerin çözümü ve yorumlanması
aşamasında ise;&nbsp; Elazığ Şahinkaya Köyü
Arkeopark alanına dair yapılan analiz, oluşturulan veriler ve anketler neticesinde
yorumlanıp öneriler getirilmiştir. Bulgular:
Elazığ’da bugün İslam ve Hıristiyan dinlerine mensup, Türk, Kürt ve Ermeni gibi
etnik kökene sahip yurttaşlar bir arada yaşamaktadır. Çalışmada yapılan 25
soruluk anket verileri doğrultusunda, Elazığ’da ki halkın kültürel ve tarihi
mirasını korumak istediği fakat çocuklarını müzelere ve tarihi mekânlara
götürme durumunun çok düşük olduğu saptanmıştır. Sonuç:&nbsp; Kültür turizmi
açısından arkeolojik sit alanlarının önemi günden güne artmakta ve bu
doğrultuda peyzaj mimarlığı meslek disiplini tarafından oluşturulacak peyzaj
planlama ve tasarımlarına ihtiyaç duyulmaktadır. Bu çerçevede; Elazığ ili
Şahinkaya köyüne bir arkeopark tasarımı önerisi getirilmiştir.
JURISTAS DO COMISSIONISMO: USOS E MOBILIZAÇÕES DO DIREITO NA COMISSÃO DA VERDADE DA UNB
Authors: Lima Amanda Evelyn 
Published: June 2018

A Comissão Anísio Teixeira de Memória e Verdade (CATMV) da Universidade de Brasília foi a primeira comissão da verdade instalada em uma universidade em todo o mundo. A CATMV foi responsável por investigar as graves violações de Direitos Humanos ocorridas na UnB durante o período autoritário de 1964 a 1988. Este trabalho é parte de uma pesquisa de fôlego sobre o fenômeno do comissionismo no Brasil, que coletou informações das mais de cem comissões da verdade instaladas no país. Seu objetivo é evidenciar a presença, o uso e mobilizações do Direito na comissão da verdade da UnB através das narrativas apresentadas por seus comissionados e demonstrar que o fenômeno do comissionismo pode também ser interpretado como uma etapa de um processo de expansão de mercado para os profissionais dos direitos humanos.
Inércia inflacionária: uma análise de raiz unitária nos índices de inflação no Brasil para o período recente
Authors: Faião Thais Fernanda , Perdigão Claudia , Caldarelli Carlos Eduardo , Camara Marcia Regina Gabardo da 
Published: June 2018

O objetivo desse artigo é analisar a trajetória de índices de inflação brasileiros selecionados, a fim de identificar se esses possuem comportamento inercial no período de 2000 a 2015. A presença de inércia inflacionária envolve uma questão fundamental acerca da dinâmica dos preços da economia, pois depois de estabelecidos os mecanismos de indexação, tanto a inflação passada e a sua expectativa futura, conseguem determinar os preços e salários correntes. A análise é realizada nos índices IGP-M, IPCA, e IPCA desagregado em Alimentos e Bebidas, Produtos Industriais, Serviços e Monitorados, através da aplicação de testes de raiz unitária, nas séries em nível e nas séries dessazonalizadas por alisamento exponencial do tipo Holt-Winters. O período analisado refere-se ao pós-Plano Real, entre janeiro de 2000 e setembro de 2015. Os resultados mostraram que, de forma geral, para o período completo, apenas os índices dessazonalizados dos Produtos Industriais, dos Serviços e dos Monitorados apresentaram um comportamento inercial, enquanto que para o período recente, todos os índices, tanto em nível como dessazonalizados, apresentaram esse mesmo comportamento.
NGM282 Significantly Reduces Hepatic Steatosis Independent of Type 2 Diabetes (T2D) Status or Statin Usage—Results from a Phase 2 Trial in Patients with Nonalcoholic Steatohepatitis (NASH)
Authors: DEPAOLI ALEX , ROSSI STEPHEN J. , LING LEI , HARRISON STEPHEN A. , ABDELMALEK MANAL F. , JAROS MARK R. , SOMARATNE RANSI 
Published: June 2018

Background: NGM282 is an engineered variant of human FGF-19 that retains bile acid and metabolic regulatory activities while eliminating the tumorigenic effects of FGF-19. Multiple preclinical models showed improvements in NASH liver histology similar to those observed post-bariatric surgery. Data from a Phase 2 trial in NASH patients showed significant reductions in hepatic steatosis, liver transaminases and markers of fibrosis that were translated to histologic benefits in NASH. Both T2D status and statin therapy have been variably associated with treatment response in NASH trials. This analysis assessed NGM282 impact on liver fat content by T2D status and statin usage.
Methods: Patients with biopsy-confirmed NASH (n=82) were randomized to NGM282 3 or 6mg or placebo for 12 weeks. The primary endpoint was ≥5% reduction in absolute liver fat content (LFC) by MRI-PDFF. Patients were stratified by T2D status at baseline and categorized as statin/no statin use (3 months prior to screening). Statin therapy was stable during the study. Treatment responses were analyzed using an ANCOVA model; NGM282 treatment arms were pooled (n=53).
Results: T2D and statin use was present in 62% and 45% of the NGM282 treated patients, respectively. There was no significant difference in LFC reduction in patients with T2D vs. no T2D (-10.4% vs.-11.2%, p=0.59) or statin use vs. no statin use (-10.7% vs. -10.7%, p=0.99) at baseline. Absolute LFC was decreased by -9.7% and -11.9% for NGM 282 3 and 6mg (p&lt;0.001 for both), respectively. Reductions in LFC correlated with improvements in C4, HbA1c and triglycerides.
Conclusions: NGM282 is highly effective in reducing LFC, independent of T2D status or statin use. These data support the activity of NGM282 in NASH across a broad patient population. Ongoing studies will evaluate the translation of these effects into improvements in fibrosis and resolution of NASH.

Disclosure
A. DePaoli: Research Support; Self; Eli Lilly and Company, Merck Sharp & Dohme Corp. S.J. Rossi: Employee; Self; NGM Bio. Stock/Shareholder; Self; NGM Bio. L. Ling: Employee; Self; NGM Biopharmaceuticals. Stock/Shareholder; Self; NGM Biopharmaceuticals. S.A. Harrison: Research Support; Self; Novo Nordisk A/S. Consultant; Self; Novo Nordisk A/S. Research Support; Self; NGM Bio. Advisory Panel; Self; NGM Bio. Consultant; Self; NGM Bio. M.F. Abdelmalek: Advisory Panel; Self; NGM Bio. Consultant; Self; NGM Bio. Research Support; Self; NGM Bio. M.R. Jaros: Consultant; Self; NGM Bio. R. Somaratne: Employee; Self; NGM Biopharmaceuticals. Stock/Shareholder; Self; NGM Biopharmaceuticals.
Comparison of Ultra-Rapid-Acting Insulin’s Effect—Randomised, Triple Crossover Study
Authors: TAKEISHI SOICHI , TSUBOI HIROKI , TAKEKOSHI SHODO 
Published: June 2018

We investigated which ultra-rapid acting insulin (URI) is the most effective in improving glycemic variability (GV)- insulin glulisine (G), insulin lispro (L) or insulin aspart (A). We calculated a required sample size of 12. Thirty type 2 diabetic patients were randomly allocated to 3 groups. On admission, preprandial and bedtime glucose levels (PB)(GL) were stabilized at 80 mg/dL level with URI (before wearing continuous glucose monitoring (FreeStyle Libre Pro) device (FLP); G) and insulin glargine 300 U/ml (G300) during the study period. Group 1: PBGL were stabilized; next, the same dose G was taken, patients wore a FLP and GV was evaluated on days 3 and 4; G was then switched to the same dose L, and GV was evaluated on days 8 and 9; finally, L was switched to the same dose A and GV was evaluated on days 13 and 14. Group 2: URI was taken in the order of L, A, G, following the same regimen. Group 3, URI was taken in the order of A, G, and L, following the same regimen. URI was administered at 08:00, 12:00, 18:00. G300 was administered at 08:00. Data collected on the second evaluation day were analysed. Test meals were given. Increased postprandial (Po) GL, Po glucose gradients, area over the glucose curve (&lt;70 mg/dL) were significantly lower in patients on G, L, A, in that order. Start time of hypoglycemia occurrences (HO) was significantly earlier and finish time of HO was significantly later in patients on A than L. G is the best URI to improve GV.

Disclosure
S. Takeishi: None. H. Tsuboi: None. S. Takekoshi: None.
Ultra-rapid Lispro (URLi) Reduces Postprandial Glucose Excursions vs. Humalog® in Patients with T2D at Multiple Meal-to-Dose Timing Intervals
Authors: KAPITZA CHRISTOPH , LEOHR JENNIFER , LIU RONG , REDDY SHOBHA , DELLVA MARY A. , MATZOPOULOS MARK , KNADLER MARY P. , MEI TENG LOH , HARDY THOMAS , KAZDA CHRISTOF M. 
Published: June 2018

URLi (LY900014), a novel ultra-rapid mealtime insulin in Phase 3 development, is shown to reduce postprandial glucose after subcutaneous injection. This 2-part, randomized, double-blind, Phase 1b study evaluated differences in PK and PD between URLi and insulin lispro (Humalog®; HL) in 30 patients with T2D. Part A used a 6-period crossover design to assess safety and compare PK and postprandial glucose response to solid mixed meal tolerance tests (MMTT) with URLi or HL at different injection to mealtime intervals (-15, 0 and +15 min). Part B evaluated safety, PK and PD during 2 weeks of multiple daily dosing (immediately before a meal) in a parallel design.In Part A, URLi reduced glucose excursions (assessed as change in area under the concentration curve vs. time [∆AUC]) during the first 2 hours (∆AUC0-2h) and entire 5 hours (∆AUC0´5h) of the MMTT regardless of dose timing (Fig). URLi reduced ∆AUC0-2h by 37% (p=0.014), 47% (p&lt;0.0001), and 4% (p=NS) and ∆AUC0-5h by 49% (p=0.049), 105% (p&lt;0.0001), and 29% (p=0.076) vs. HL at ´15, 0 and +15 min (significance level =0.1). The PK and PD profiles for URLi and HL were sustained after 2 weeks of outpatient dosing (Part B). More hypoglycemic events occurred with URLi during MMTTs but these were mild and mostly asymptomatic. Only a few events occurred in either group during 2 weeks of outpatient dosing. Local tolerability was similar between treatments.

Disclosure
C. Kapitza: Research Support; Self; ADOCIA, Boehringer Ingelheim GmbH, Dance Biopharm, Eli Lilly and Company, Johnson & Johnson Services, Inc., MedImmune, MSD K.K., Mylan, Nordic Bioscience, Novo Nordisk Inc., Poxel SA, Roche Diagnostics Corporation, Saniona, Sanofi-Aventis, Senseonics, Zealand Pharma A/S. J. Leohr: Employee; Self; Eli Lilly and Company. Stock/Shareholder; Self; Eli Lilly and Company. Employee; Spouse/Partner; Accenture. Stock/Shareholder; Spouse/Partner; Accenture. R. Liu: Employee; Self; Eli Lilly and Company. Employee; Spouse/Partner; Eli Lilly and Company. S. Reddy: None. M.A. Dellva: Employee; Self; Eli Lilly and Company. M. Matzopoulos: None. M.P. Knadler: Other Relationship; Self; Eli Lilly and Company. M. Loh: Employee; Self; Eli Lilly and Company. T. Hardy: Employee; Self; Eli Lilly and Company. Stock/Shareholder; Self; Eli Lilly and Company. C.M. Kazda: Employee; Self; Eli Lilly and Company.