bluuebunny/crossref_metadata_2025_split huggingface dataset:
TIME INTERVALS AT DIFFERENT STAGES OF MEDICAL CARE IN ACUTE CORONARY SYNDROME WITH ST SEGMENT ELEVATION ON THE ECG
Authors: Lobanova A. N. , Petrova M. M. , Harkov E. I. , Tsibulskaya N. Yu. 
Published: December 2024

Objective: to analyze the time intervals of medical care for patients with acute coronary syndrome with STsegment elevation on an electrocardiogram at different stages of care.Materials and methods. The study included 189 patients of both genders hospitalized with a diagnosis of acute coronary syndrome with ST-segment elevation, 3 age groups were formed, according to WHO criteria: 1 group (up to 59 years old) – 72 patients, 2 group (60–75 years old) – 69 patients and 3 group (over 76 years old) – 48 patients. The analysis of the time intervals of care at different stages was carried out, the intervals were compared in the group of men and women, as well as in different age groups.Results. The time interval from PMC to hospitalization in cPCI was 33 minutes, the interval from PMC to the start of PCI was 90 minutes, which corresponds to the standards of care. The median time to seek care from the onset of symptoms in our study was 191,65 ± 142,49 min. No gender differences were identified in seeking care. Younger patients (group under 60 years) sought care reliably earlier from the onset of symptoms than older patients, which is probably due to a more erased clinical picture in older patients.Conclusion. The main delay occurs at the symptom-PMC stage, which is the main problem. This indicator depends on the awareness of the population about the symptoms and danger of ACS. To improve this indicator, it is necessary to carry out educational work. The result of this activity should be an earlier recognition of ACS symptoms by patients and a reduction in the time from the onset of symptoms to the call of the NSR.
ANALYSIS OF THE INCIDENCE OF ACUTE INTESTINAL INFECTIONS OF VIRAL ETIOLOGY IN THE OMSK REGION
Authors: Puzyreva L. V. , Sergeeva V. V. , Sivolapova O. N. 
Published: December 2024

The aim of the research. to analyze the incidence of acute intestinal infections in the Omsk region, identifying the proportion of viral diarrhea in individuals under 17 years of age.Materials and methods. The main reporting forms of Rospotrebnadzor for the period from 2017 to 2023 were used. Descriptive statistics methods and dynamic series analysis were applied. A forecast was built.Results. In the region, acute intestinal infections often remain of unknown origin. Among acute intestinal infections with an established cause, persons under 17 years of age accounted for more than 70,0%. When building a forecast, it was revealed that the situation will not change for 2024.Of the identified causes of diarrheal syndrome, viruses such as rotavirus, Norwalk, and enterovirus were most often recorded. Over seven years, the share of rotavirus infection was 82,6%, noravirus infection – 8,7%, enterovirus infection – 6,9%. In persons under 17 years of age, rotavirus gastrointestinal tract lesions were observed in 74,8%, norovirus disease in 59,9%, and enterovirus intestinal manifestation in 98,6% of children. In general, during the study period, the share of viral intestinal infections in persons under 17 years of age was 75,0% of all confirmed cases among the population. Outbreaks of intestinal infection in the region were analyzed. The average value of outbreak incidence over 7 years was 0,64 ± 0,003 % of all registered cases of acute intestinal infection. Foci of infection were mainly located in preschool institutions, where the source was people, and the route of transmission was contact-household. In all cases, viral intestinal infection was confirmed. The leading cause of foci of intestinal infection was the Norwalk virus (54,1%). An outbreak of isolated rotavirus infection was detected in 35.1%, and in combination with norovirus – 2,7%. Enterovirus was the cause of group morbidity in 8,1% of cases. Norovirus infection foci in 100% of cases were found in preschool institutions. Conclusion. In the Omsk region, there is a tendency for low verification of diarrheal syndrome in the population, which affects the under-detection of patients or carriers of acute intestinal pathogens. Viral diarrhea prevails among the population, among which people under 17 years of age make up the majority.
CHANGES IN TRYPTOPHAN METABOLISM AND CYTOKINE CONCENTRATION IN SYNOVIAL JOINT TISSUE IN RHEUMATOID ARTHRITIS
Authors: Stepanov E. A. , Bayaskhalanova C. B. , Fefelova E. V. , Stepanov A. V. , Tereshkov P. P. , Stepanova M. O. , Tsybikov N. N. 
Published: December 2024

The aim of the research. To identify changes in tryptophan and cytokine metabolism in synovial joint tissue in rheumatoid arthritis. Research materials and methods. The experiments were performed on 40 WISTAR rats. At the beginning of the study, each animal of the experimental groups received an intraperitoneal injection of collagen type 2 solution (Chondrex, Inc., USA) in Freund's incomplete adjuvant. The content of tryptophan, kynurenine, 3-hydroxykinurinine, L-5-hydrotryptophan by HPLC with fluorimetric and spectrophotometric detection, and the concentration of cytokines: IL1b, IL6, IL10, IL17, IL18, TNFa were determined in the tissues of the synovial membrane of the knee joint. They were determined using Rat Inflammation Panel V02 multiplex assay kits (Biolegend, USA) on a Cytomics FC500 flow cytofluorimeter (Beckman Coulter, USA). Statistical analysis was performed using the Jamovi program version 2.3.Results. The concentration of cytokines: IL1b, IL6, IL10, IL17, IL18, TNFa was found to be high during the acute development of rheumatoid arthritis. With experimental rheumatoid arthritis, the content of tryptophan metabolites along the kynurenine pathway increases and the concentration of metabolites along the serotonin pathway decreases. Direct positive correlations of IL1b, IL6, IL10, IL17, IL18, TNFa with the content of tryptophan metabolites along the kynurenine pathway have been established.Conclusions. Tryptophan metabolism and IL1b, IL6, IL10, IL17, IL18, and TNFa content are altered in rheumotoid arthritis.
CHANGES IN THE INDICATORS OF THROMBUS FORMATION AND FIBRINOLYSIS IN THE PATHOGENESIS OF CEPHALOHEMATOMA IN NEWBORNS
Authors: Sushchenko R. A. , Panchenko A. S. 
Published: December 2024

Background. Long-term resorption of cephalohematoma may be accompanied by the formation of surgical complications. The rate of resorption of cephalohematoma has uncertain dynamics and may depend on the characteristics of hemostasis in newborns.Aim. To define the level of thrombus formation and fibrinolysis in venous blood plasma in newborns with cephalohematomas.Methods. There were 90 newborns under observation, 30 – with medium and large-sized cephalohematomas (the cephalohematoma was punctured), 30 – with small-sized cephalohematomas (the cephalohematoma was not punctured). The control group – 30 healthy newborns. The level of thrombosis and fibrinolysis indicators was determined by flow cytometry on a Cytoflex LX device using multiplex analysis kits. Results. On the 10th day, the level of prothrombin in newborns of the first group was 1,33 times higher than in the control group, and 1,47 times higher than in the second group of the study. On the 10th day, the concentration of antithrombin III in the first and second groups exceeded the control group by 5.28 and 8,82 times, and on the 28th day of the study by 6,9 and 7,.28 times. The concentration of type 1 plasminogen activation inhibitor in the first and second groups was higher than in the control group by 3,11 and 5,25 times on the 10th day, and on the 28th day of the study by 2,88 and 3,93 times. The level of D-dimer on the 10th day in the first and second groups was 1,43 and 1,71 times higher, and on the 28th day in both groups it was 1,6 times higher than the control group.Conclusion. Reparation for cephalohematomas is associated with mechanisms of resorption of subperiosteal hemorrhage and depends on the fibrinolytic activity of the hemostatic system. It is likely that the isolation of the cephalohematoma from the systemic circulation under conditions of inhibition of plasminogen activity may be the cause of long-term persistence of subperiosteal hemorrhage.
Repeat surgeries using anterior abdominal wall flaps after single-stage breast reconstruction (literature review)
Authors: Kazaryan S. G. , Startseva O. I. , Ermoshenkova M. V. 
Published: December 2024

Immediate breast reconstruction using endoprostheses is the most commonly performed reconstructive breast procedure in both the UK, USA and Russia, reaching 80% of all types of reconstruction. Tertiary reconstruction after previous breast surgeries may be required in case of complications of failed breast reconstruction or recurrence of disease. In foreign literature, the term tertiary reconstruction is commonly used for repeat reconstructive surgery. A literature review was conducted using the keywords: “одномоментная реконструкция молочной железы”, “reoperation in breast reconstruction”, “secondary reconstruction after immediate breast reconstruction”, “tertiary reconstruction with autologous tissue”.It has been established that repeated operations using anterior abdominal wall flaps after one-stage breast reconstruction have a good healing outcome and satisfy the aesthetic needs of patients.Conclusion. Tertiary reconstruction after a long period of implant placement is motivated by undesirable symptoms (breast pain, psychological discomfort), cosmetic dissatisfaction of patients, late infections, development of cancer of the contralateral breast or recurrence of the disease on the side of reconstruction.
Changes in heart rate variability after rhinosurgical interventions
Authors: Nashvan A. , Markushin A. A. , Timoshenko A. V. , Kotov V. N. , Kastyro I. V. , Popadyuk V. I. , Ganshin I. B. , Kartasheva A. F. 
Published: December 2024

Purpose: to study changes in heart rate variability (HRV), as an indicator of the stress response, after rhinosurgical interventions.Material and methods. A study of heart rate variability was conducted in 98 patients in the perioperative period who underwent open rhinoplasty (1st group, 33 patients), open rhinoplasty with simultaneous septoplasty (2nd group, 33 patients), and septoplasty (3rd group, 32 patients). Heart rate variability was assessed before surgery, 3, 6, 24 and 48 hours after surgery. The low frequency component (LF), high frequency component (HF), and very low frequency component (VLF) of HRV were studied.Results. In the 3rd group of patients, compared with the data before surgery, the high-frequency component of HRV significantly decreased on the 3rd and 24th hours after surgery (p < 0.001), but increased after two days (p < 0.001). 3 hours after surgery, HF HRV in patients of 1st group was significantly higher than in patients of groups 2nd and 3rd (p < 0.001). In the second group, a significant decrease in HF was noted in the first 3 (p < 0.001), 6 hours (p < 0.01), 24 hours (p < 0.05) and 48 hours (p < 0.001) of the postoperative period, compared with data before surgery. In 3rd group, at intervals after surgery of 3 and 24 hours (p < 0.001), as well as 6 hours (p < 0.001), LF was significantly lower than before septoplasty. 3 hours after surgery, the VLF in the rhinoplasty group was significantly higher than in the other groups (p < 0.001). At the 6th hour there were no differences between the groups. After 24 hours, in the septoplasty group, VLF was significantly lower than in 11st and 2nd groups (p <0.01).Conclusion. Septoand rhinosptoplasty provoke an inadequate low response from the sympathetic nervous system in the first hours after surgery, which is manifested by low LF power and indicates a violation of adaptive responses maladaptation. A decrease in VLF power in the first 3 hours after septoand rhinoseptoplasty indicates a pronounced stressor effect, which leads to low adaptive capabilities compared to rhinoplasty, that is, maladaptation within the specified period.
Formation of a sphincter mechanism in colostomy using titanium nickelide implants in an experiment
Authors: Korobeinikova V. I. , Dambaev G. Ts. , Soloviev M. M. , Kurtseitov N. E. , Vtorushin S. V. , Gunther V. E. , Khodorenko V. N. , Anikeev S. G. , Borodina S. V. , Kaydash O. A. , Bukterov M. V. , Vasilchenko D. V. , Ufandeev A. A. , Avdoshina E. A. , Pobezimova A. S. , Li V. S. 
Published: December 2024

Purpose of the study: to conduct a comparative assessment of the formation of the sphincter mechanism during colostomy using titanium nickelide-based implants in an experiment.Material and methods. The experimental study was conducted on 45 sexually mature male rats Wistar with an average body weight of (531.3 ± 13.4) g. The animals were randomized into three equal groups of 15 animals each. In the 1st experimental group, a cylindrical spiral made of titanium nickelide with invagination of the serosalmuscular layer of the colon was used to create a colostomy. In the 2nd experimental group, a similar spiral was used, but without invagination of the serous-muscular layer. The control group underwent the standard procedure of single-barrel colostomy formation. Animals were removed from the experiment on the 7th, 30th and 60th days after the operation, 5 animals at each stage. Histologic examination of the area of the formed colostomy with constipation apparatus was performed.Results. The use of cylindrical spiral implants from titanium nickelide in colostomy formation (both with and without invagination of the serosal-muscular layer of the colon) had no significant effect on the dynamics of body weight of experimental animals compared to the classical method. Colostomy formation without invagination of the serous-muscular layer did not lead to an increase in the incidence of postoperative complications in comparison with the traditional method. However, invagination of the serous-muscular layer was accompanied by an increased incidence of complications in the postoperative period.Conclusion. The complex analysis of experimental data, including the assessment of survival rate, body weight dynamics, incidence of postoperative complications, morphological changes, the course of regenerative processes and stoma functionality, allows us to recommend as a promising method of colostomy the use of a cylindrical spiral made of titanium nickelide without invagination of the serous-muscular layer of the intestine.
The consequences of after-hours work: a fixed-effect study of burnout, pain, detachment and work–home conflict among Norwegian workers
Authors: Bernstrøm Vilde Hoff , Ingelsrud Mari , Nilsen Wendy 
Published: December 2024

OBJECTIVES: Working outside the workplace and ordinary work hours has become common for a larger part of the working population. The objective of the current study was to examine the relationship between working after-hours and employee burnout, musculoskeletal pain, detachment and work–home conflict, delineating the independent effect of four different types of after-hours work, and the moderating role of work-time control.
METHODS: The data comprised longitudinal questionnaire data from 1465 full-time employees in Norway across four waves (2021–2022). We examined the link between four types of after-hours work: (i) long daily work hours (>10 hours); (ii) late evening work (after 21:00 hours); (iii) quick returns (<11 hours continued rest); and (iv) long weekly work hours (>40 hours a week) and employee health and wellbeing (ie, work–home conflict, detachment, burnout, and musculoskeletal pain), in fixed effects models. We stratified the analyses by working-time control.
RESULTS: The results support a link between late evening work, long daily and weekly work, and higher work–home conflict and lower detachment as well as between weekly work hours and higher burnout. The findings yielded limited support for work-time control as a moderating factor; the link between quick returns and burnout was only evident for employees with below-average work-time control.
CONCLUSIONS: The four types of after-hours work were all independently related to at least one employee outcome, although the link with quick returns was only evident when work-time control was below average. The results are important for practitioners aiming to implement family-friendly and healthy practices.
Influence of Quality of Recorded Lessons on Teaching Practices among Public Lower Day Secondary Schools Teachers in Gasabo District, Rwanda
Authors: Philemon Mugwaneza , Nduta Kiarie Martha Nduta Kiarie 
Published: December 2024

The study aimed to examine the influence of quality of recorded lessons on teaching practices among public lower day secondary school teachers in Gasabo District, Rwanda. Descriptive survey was conducted among 233 teachers experienced in using recorded lessons and 17 headteachers from 17 public lower day secondary schools. Data were collected through questionnaires for teachers and interviews for headteachers. The collected data were edited, coded, and entered into IBM SPSS Version 26 for analysis. Data were analyzed using means, percentages, standard deviations and regression analysis. Regression analysis revealed 67% of variation in teaching practices adopted by teachers who use recorded lessons can be explained by the quality of recorded lessons in REB-e Learning channel, suggesting that the quality of recorded lessons has a strong influence on teaching practices. The study recommends that educational authorities continue to avail recorded lessons for teachers and expand the quality of REB e- Learning channel to further enrich teaching practices. The study also suggested that MINEDUC through REB should also provide modalities for teachers to record their own lessons which would offer them an opportunity to reflect on their own practice. The study suggests that a comparative study should be conducted between schools that actively integrate recorded lessons and those that do not, to provide valuable insights into the tangible impact on teaching practices and students' performance and engagement.
Revisão de escopo sobre a dimensão jurídica relativa aos desafios do ambiente construído e sustentabilidade em destinos turísticos brasileiros
Authors: Motta Natália Fernandes da , Stefano Ercília de , Castañon José Alberto Barroso 
Published: December 2024

O objetivo geral da pesquisa é elaborar uma revisão de escopo sobre os desafios da dimensão jurídica do ambiente construído em destinos turísticos brasileiros pelos preceitos da sustentabilidade. A pesquisa é exploratória, descritiva, de natureza qualitativa e quantitativa, realizada através de dados secundários coletados no Portal Publicações de Turismo (2024) utilizando o termo “Direito” filtrando por (a) palavra-chave (n=34) e (b) título (n=50). Destes, apenas (n=12) tratavam exatamente a relação entre turismo e direito tendo como foco o ambiente construído no Brasil. Utilizou-se o suporte de três softwares, sendo: (1) Revisão de Escopo: para abordagem geográfica dos objetos de estudos relativos ao ambiente construído nos textos que abordaram o Direito enquanto uma perspectiva de análise, usou-se o QGis (2024); Planilhamento, que permitiu a geração de gráficos sobre: (a) arco temporal (2008-2024), ou seja, mais de uma década que a temática vem sendo tratada na literatura científica do turismo; (b) periódicos científicos que deram maior audiência a temática (Revista Licere, n=6); (c) área do direito mais proeminente: Direito da Cidade (n=8); posicionamento mais expressiva da dimensão jurídica, quanto a Pirâmide de Kelsen: meio (n=9); (2) Análise Textual: (a) Voyant Tools (2024) a partir de dois recursos (a1) Cirrus (Nuvem de Palavras); (a2) Diagrama de Fluxo, ambos identificando e ratificando a área temática pelos termos mais frequentes.
Patients With Diabetes on Sodium-Glucose Cotransporter-2 Inhibitors Undergoing Total Knee Arthroplasty Are at Increased Odds for a Number of Postoperative Adverse Events But Reduced Risk of Transfusion
Authors: Kim Lucas Y. , Wiznia Daniel H. , Grauer Jonathan N. 
Published: December 2024

Introduction:
Diabetes mellitus (DM) is a common comorbidity in total knee arthroplasty (TKA) patients, which has been associated with multiple complications. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are one class of medications recently approved to better manage DM. This study investigates the correlation of SGLT2i use on postoperative complications and revision rates for diabetic patients undergoing TKA.

Methods:
The M157 PearlDiver database was used to identify DM patients undergoing primary TKA. Those prescribed SGLT2i were identified and matched in 1:4 ratio with control DM patients based on age, sex, obesity diagnosis, and Elixhauser comorbidity index. Ninety-day adverse events and 5-year rates of revision were abstracted and compared by multivariable regression, controlling for age, sex, Elixhauser comorbidity index, long-term insulin use, obesity, metformin use, and active tobacco use.

Results:
A total of 164,474 TKA patients with DM were identified, of which SGLT2i were prescribed for 9,246 (5.6%). On multivariable analysis, SGLT2i use in DM patients was independently associated with higher odds of aggregated adverse events driven by myocardial infarction (odds ratio [OR] 2.40), sepsis (OR 1.81), urinary tract infection (OR 2.10), pneumonia (OR 1.87), and acute kidney injury (OR 1.33) but had lower odds of transfusion (OR 0.31) (P < 0.0001 for each). On multivariable analysis, 5-year survival to revision TKA were not markedly different between the matched cohorts.

Discussion:
SGLT2i are being increasingly prescribed for DM patients undergoing TKA. Although they are associated with increased risk of multiple 90-day perioperative adverse outcomes, they are also associated with reduced incidence of blood transfusion. These results may guide surgical decision making and counseling for patients taking this group of medications and align with some prior studies related to glucagon-like protein-1 agonists.
Pengembangan Media Permainan Mipon's Daily untuk Meningkatkan Kemampuan Berhitung Anak Usia Dini
Authors: Pebriani Ela , Margaretha Lydia , Nurjaya Nurjaya , Mustika Seli 
Published: December 2024

Tujuan penelitian ini adalah untuk: (1) Mengembangkan media permainan Mipon's Daily untuk meningkatkan kemampuan berhitung anak usia dini (2) mendeskripsikan keefektifan media permainan Mipon's Daily untuk meningkatkan kemampuan berhitung anak usia dini. Subjek penelitian ini adalah 30 anak berusia 5-6 tahun dari PAUD Sandi Indah Lestari, Kecamatan Sukaraja, Kabupaten Seluma, menjadi fokus penelitian ini adalah media permainan Mipon's Daily untuk meningkatkan kemampuan berhitung anak usia dini. Penelitian ini dilakukan dengan pendekatan “research and development”. Tujuan penelitian dan pengembangan adalah untuk menemukan, mengembangkan dan memvalidasi produk, sehingga penelitian dapat berkelanjutan. Penelitian dan pengembangan merupakan proses menghasilkan produk baru dan menguji efektivitas produk tersebut. Berdasarkan analisis yang digunakan dalam penelitian ini diperoleh hasil sebagai berikut: (1) media permainan Mipon's Daily untuk meningkatkan kemampuan berhitung anak usia dini dianggap sebagai platform kongkrit dan menarik perhatian anak untuk meningkatkan kemampuan berhitung anak. (2) Model media permainan Mipon's Daily untuk meningkatkan kemampuan berhitung anak usia dini dikembangkan sebagai jenis media yang baik sebagai alat bantu pembelajaran untuk meningkatkan kemampuan berhitung anak PAUD Sandi Indah Lestari, Kecamatan Sukaraja, Kabupaten Seluma. Peningkatan kemampuan berhitung signifikan berdasarkan hasil uji t dengan taraf signifikansi 0,00 kurang dari 5%. Penggunaan media permainan Mipon's Daily dapat meningkatkan kemampuan berhitung anak. Setelah menggunakan media permainan Mipon's Daily untuk meningkatkan kemampuan berhitung anak usia dini kemampuan berhitung anak lebih tinggi dibandingkan sebelum menggunakan media permainan Mipon's Daily untuk meningkatkan kemampuan berhitung anak usia dini.