bluuebunny/crossref_metadata_2025_split huggingface dataset:
First Field Use of Electric Roller Screw Actuated Choke Designed for Managed Pressure Drilling
Authors: Parker Martyn , Nauduri Sagar , Spahn Micah , Klemetson Ryan 
Published: March 2018

Abstract
Automatic and remote operated drilling chokes have been in the petroleum industry for a very long time. Managed Pressure Drilling (MPD) operations have been using these chokes since ±2006 and prior to that Underbalanced Drilling (UBD) operation have been using them for decades. The main control or actuation of these drilling chokes is achieved by adapting standard API-16C hydraulic or electric actuated worm gear drive actuators. These methods of actuation however have limitations related to ‘Response Time’ and ‘Equipment Failure', making these actuators less desirable for MPD applications.
An advanced method of actuation using ‘Electro Servo Actuator’ is presented as an alternative to alleviate these challenges. These electro servo actuators are designed from the outset considering the requirements of MPD Choke operations, and are optimized to provide precise control of chokes along with a reduction in the number of potential failure points.
During extensive laboratory testing, required as a quality standard for our MPD choke's factory acceptance program, these actuators provided very accurate and responsive pressure control to quick changes in pressure demands based on variations in both set point and flow. Furthermore, the initial field testing of the actuator in the MPD field operations demonstrated the same precise and accurate pressure control tracking, along with better performance at ‘lower flowrates’ when compared to worm gear driven chokes. Full-scale field application on over 20 different projects across North America, including a wide range of severe weather conditions, exceeded the expectations and results from initial testing.
In conclusion, the use of this new ‘Electro Servo Actuator’ technology greatly increases the precise control of drilling chokes very crucial for all MPD applications. This technology reduces the potential failure points in the actuators. It enhances the uptime of the actuator and its life cycle, thereby minimizing the need for routine maintenance. Its smaller size and design enables development of more compact MPD chokes and equipment.
New Benzodioxole-based Pyrazoline Derivatives: Synthesis and Anticandidal, In silico ADME, Molecular Docking Studies
Authors: Özdemir Ahmet , Sever Belgin , Altıntop Mehlika Dilek 
Published: March 2018

Background:
Azoles are commonly used in the treatment and prevention of fungal
infections. They suppress fungal growth by acting on the heme group of lanosterol 14α-demethylase
enzyme (CYP51), thus blocking the biosynthesis of ergosterol.
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Objectives: Due to the importance of pyrazolines in the field of antifungal drug design, we aimed to
design and synthesize new pyrazoline-based anticandidal agents.

Methods:
New pyrazoline derivatives were synthesized via the reaction of 1-(chloroacetyl)-3-(2-
thienyl)-5-(1,3-benzodioxol-5-yl)-2-pyrazoline with aryl thiols. These compounds were evaluated
for their in vitro antifungal effects on Candida species. Docking studies were performed to predict
the affinity of the most effective anticandidal agents to substrate binding site of CYP51. Furthermore,
MTT assay was performed to determine the cytotoxic effects of the compounds on NIH/3T3
mouse embryonic fibroblast cell line. A computational study for the prediction of ADME properties
of all compounds was also carried out.

Results:
Compounds 5, 8, 10 and 12 were found as the most potent anticandidal agents against
Candida albicans and Candida glabrata in this series with the same MIC values of ketoconazole
and they also exhibited low toxicity against NIH/3T3 cells. Docking results indicated that all these
compounds showed good binding affinity into the active site of CYP51. In particular, chloro
substituted compounds 8 and 12 bind to CYP51 through direct coordination with the heme group.
According to in silico studies, compound 8 only violated one parameter of Lipinski’s rule of five,
making it a potential orally bioavailable agent.

Conclusion:
Compound 8 was defined as a promising candidate for further in vitro and in vivo
studies.
Identifying the Optimal Fractionation Schedules for Improved Response Rates and Survival in Patients with Metastatic Melanoma Treated with Ipilimumab and Radiotherapy
Authors: Liu Jason , Xu Cong , Zhu Junjia , Sivik Jeffrey , Drabick Joseph J. , Mackley Heath B. 
Published: March 2018

Objective:
There is a growing body of evidence that combining ipilimumab with higher
doses of radiotherapy may improve the response rates and survival in patients with metastatic melanoma
compared to lower doses of radiotherapy. However, the dose cutoff at which improved outcomes
are more likely to occur has not been properly identified.

Methods:
We conducted a retrospective analysis of 100 patients treated with ipilimumab and radiotherapy
for metastatic melanoma at a single institution from May 2011 to January 2017. Demographic,
clinical, and treatment factors, including the biological equivalent dose (BED) with an α/β
of 7, were recorded. Endpoints of interest included infield and global complete response (CR) after
the completion of radiation and ipilimumab based on the RECIST criteria (v1.1) and 12-month
overall survival (OS).

Results:
The BED cutoffs at which improved outcomes are more likely to occur are 46.5 Gy for infield
CR, 50.9 Gy for global CR, and 46.5 Gy for 12 month OS. The least aggressive fractionation
schedules used in this patient population that have a BED above the threshold for all 3 outcomes include
40 Gy in 20 fractions, 30 Gy in 6 fractions, and 24 Gy in 3 fractions.

Conclusion:
This hypothesis-generating study suggests that patients who cannot receive ablative intent
radiotherapy may be more likely to benefit from concurrent radiotherapy with ipilimumab if
their fractionation schedule has a BED above 46.5 - 50.9 Gy. Prospective trials evaluating this question
should be considered.
AN INVESTIGATION ON MODELING OF DALAMAN STREAM FLOWS BY USING WAVE-ANFIS
Authors: TAYLAN Dilek 
Published: March 2018

The object of the study is to investigate a flow estimation
model by using a combination of Wavelet Transform Technique (W) and Adaptive Neural
Based Fuzzy Inference System (ANFIS). Many models has been applied in recent
years for the prediction of Dalaman Stream flow in the south of Turkey. One of
these studies was AR-ANFIS models which developed by Taylan (2008), its
training data set was extended with synthetic series produced by autoregressive
processes. In this study, W-ANFIS models were developed with sub-series
generated by wavelet analysis by using extended training set of ANFIS models. It is seen that increasing the number of
input data in training increases model performance. Compared with the developed
models, it has been shown that the W-ANFIS hybrid models have a better
predictive power than the AR-ANFIS models. Consequently, the W-ANFIS hybrid
model could be used successfully in predicting of flow.
GÜRCİYEF METODUNDA MÜZİK UYGULAMALARI VE PİYANO MÜZİKLERİNİN TEMEL ÖZELLİKLERİ
Authors: BİRGÜL AKÇAKMAK Hale 
Published: March 2018

20. yüzyılın başında Batı dünyasına sanat uygulamaları
odaklı bir öğreti sunan Gürciyef, müziklerinde birçok farklı kaynaktan
yararlanmıştır. Müzik yazma sürecinin dinleyici önünde gerçekleştiği ve pratik
alanda yapılan çalışmaların parçası olan müzikler özgün bir dile sahiptir.
Batı’ya sunulan üretimler olan müziklerde kullanılan çok çeşitli malzeme ve
sembolik içerik, kategorize edilmesi güç niteliklere sahiptir. Tüm inançlara mesafeli, evrensel bir
üst insan modelini hedefleyen metodun aynı zamanda ciddi bir modernizm
eleştirisi ile kurduğu sıradışı, zaman zaman tutarsız ve kışkırtıcı dilinin
derin sembolik araçları, çok sonra çözümlenmeye değer bulunmuştur. İnsanın bedensel,
zihinsel ve duygusal uyumunu hedefleyen metot bağlamında yapılacak okumalarla
içerik kendini görünür kılmaktadır. Müzik dışı eğilimlerin öne çıktığı beden deneyimi
odaklı uygulamalar, insan algısının farklı biçimlerini hedeflemesi bakımından
incelemeyi bekleyen bir alan olma özelliğini günümüzde de sürdürmektedir.
Müzikler ve metodun ilişkisini kavramaya yönelik bir bakış açısı geliştirmeyi
hedefleyen bu araştırmada, Gürciyef metodunda müziğin kullanımının nedenleri ve
müzik malzemesinin temel özellikleri araştırılırken Gürciyef’e ait metinler
temel kaynak olarak kullanılacaktır.
DISCUSSION OF: Economic Analysis of Proposed PCAOB Standards: Finding a Path Forward
Authors: Ramamoorti Sridhar 
Published: March 2018

SYNOPSIS
For organizing my discussant response, I use the “input-process-output-outcomes” framework, where the PCAOB is part of the standard-setting infrastructure (input), the processes are its standard-setting activities, the standards eventually developed and approved by the SEC (the output), and assessing the outcome(s) refers to evaluating how well the PCAOB is achieving its mission and vision. From this perspective, Nolder and Palmrose's (2018) critique of the PCAOB's standard-setting pace as being “glacial” can only be regarded an “operational criticism.” In fact, viewed in light of the recently released Monitoring Group's (2017) Consultation paper, the PCAOB actually appears to be ahead of the IAASB as a much more independent and active standard-setter. Expanding the PCAOB's “economic analysis” to incorporate behavioral disciplines could certainly make the rationale more grounded and stronger, but will likely further slow down the pace of standard-setting—a result that goes against the authors' preference. Beyond just behavioral approaches, I consider the even broader perspective of “political economy” in this context and highlight the relevance of Ashby's Law of Requisite Variety (Ashby 1956) as an overarching framework. Toward the end, I support certain arguments made by Nolder and Palmrose (2018), and in particular commend their suggestion that the PCAOB develop a conceptual framework for standard-setting going forward.
Obtaining First and Second Order Nomoto Models of a Fluvial Support Patrol using Identification Techniques
Authors: Carrillo Sandra , Contreras Juan 
Published: March 2018

In this paper we present a method for obtaining a second order Nomoto model that describes the yaw dynamic of a Patrol River Boat. This model is obtained from experimental input and output data gathered from the turning circle maneuver. System identifications techniques and a gray box model are employed to find the coefficients of the Nomoto model. The results of the identification process as well as the results of validation process are presented
The Miocene Depositional Geological Evolution of Phu Khanh, Nam Con Son and Tu Chinh - Vung May Basins in Vietnam Continental Shelf
Authors: Dung Tran Thi , Nghi Tran , Hung Nguyen The , Thanh Dinh Xuan , Ngoc Pham Bao , Tuyen Nguyen Thi , Nhan Tran Thi Thanh , Trang Nguyen Thi Huyen 
Published: March 2018

The geological development history of Miocene deposits in three sedimentary basins as Phu Khanh, Nam Con Son and Tu Chinh - Vung May is actually a depositional evolution in relation to sea level change and tectonic movement. The Miocene deposits in three basins were formed in three cycles corresponding to three depositional sequences: 1/ Early Miocene sequence: In this cycle, the tectonic setting of three basins is similar to one another, the terrain is less differentiated, the environment is mainly alluvial, coastal and shallow marine-bay. Topography of top Miocene surface was strongly deformed by the tectonic events such as compression, fault, fold that had created the rough relief and eroded unconformity surface. The product of erosion processes was supply of terrigenous depositional materials for early Miocene basins under the bay type. 2/ Middle Miocene sequence: The tectonic situation of three basins started changing. The basins were differentiated into 2 parts: The inner shelf with stable geological structure and dominated terrigenous deposits; The outer shelf was stronger subsidence the basin base topography was differentiated with the development of two sediment types: carbonate bearing terrigenous sediments and carbonate reefs. 3/ Late Miocene sequence: in this period the basins were differentiated into two distinct structural zones: the western zone with incline terrain, the dominated terrigenous sediments and the eastern zone with strong differentiated terrain, reef development they played the erosion zone role and supplied a large amount of biological clastic sediments to the shallow lagoons-bay.
Faktor-Faktor yang Berhubungan dengan Tingkat Kecemasan pada Pasien Preoperative di RS Mitra Husada Pringsewu
Authors: Vellyana Diny , Lestari Arena , Rahmawati Asri 
Published: March 2018

<p>All of the nursing intervention in hospital was not certainly be positively accepted by patients. People ability has different, so that can arise the stress condition or anxiety. The prevalence of anxiety in America were more than 28%. The age who get anxiety were 9-17 years, 13% age of 18-54 years, 16% age of 55 and 11.4% of elderly. Women have risk to anxiety, two times than man. This study was to know the factors that related to anxiety level in Preoperative patient in Mitra Husada Hospital, Pringsewu, in 2016. The method of this study was a correlation with using cross sectional approach. The population were 58 respondents. Technique of sampling was using accidental sampling. Data were analyzed by univariat and bivariat using Chi square. The result showed that there were a relationship of gender, age, and economic status (p-value&lt;0.05) and there were not a relationship of level of education variable (p-value&gt;0.05) with the anxiety level of Preoperative patient in Mitra Husada Hospital, Pringsewu.</p>
Ploughshares into Swords - Colonial College Graduates in New Zealand
Authors: Derby Mark 
Published: March 2018

I have no doubt whatever in saying that all this country wants is a few hard-working men with a little capital, as there is plenty of land to be got of good quality and pretty cheap. Most of the very large sheep runs are being cut up into smaller ones … If a fellow is steady and willing to work, I believe this is about the best country to come to.
Prosaic Realities of the Work Time Dream
Authors: Henning Jon 
Published: March 2018

This essay re-examines the story of the arrival of the eight-hour day in New Zealand in the 1840s and provides some insight into three other aspects of our work time history. These aspects are the extent to which workers worked long hours in the nineteenth century, the contest between those who sought shorter hours and those who resisted, and the political progress towards shorter hours that began in the 1890s.
En el club de los aficionados a la ciencia ficción: Roberto Bolaño
Authors: Fernández Javier 
Published: March 2018

El presente artículo profundiza y sistematiza en las referencias descubiertas entre Roberto Bolaño y grandes autores del género conocido como ciencia ficción, algunas de ellas todavía sin consignar desde un punto de vista académico. Asimismo se establecen dos vinculaciones que el narrador chileno tiene con dicho género: la percepción narrativa distante, cuya perspectiva de vértigo incluye un distanciamiento o una comparativa a escala planetaria y el conjunto de motivos o temas de la ciencia ficción que le permiten a Bolaño construir arriesgadas metáforas. The article depicts the relationship between Roberto Bolaño’s works and the literary genre known as Science Fiction or SF. Based on previous academic literature that outlined this subject, the aim is to provide a deeper perspective and to offer a comparative analysis. Two will be the perspectives in which the focus will be set: the narrator’s distant perspective and the metaphoric use of common motifs.
Representación de la poesía de Andrés Sánchez Robayna en sus últimas antologías (2012 y 2016)
Authors: Ruiz Casanova José Francisco 
Published: March 2018

A partir del análisis de una antología panorámica y una autoantología de la obra lírica del poeta Andrés Sánchez Robayna, en este trabajo se reflexiona sobre las cuestiones relativas a la poética de la antología, la representatividad, la trascendencia literaria e histórica y el canon. Se trata de un acercamiento comparativo a dos modos antológicos (la antología realizada por un antólogo-editor y la antología de autor) como medios de difusión y de proyección de la obra literaria. From the analysis of a panoramic anthology and a self-antology of Andrés Sánchez Robayna’s poetry, this essay studies questions about the poetics of anthology, representativeness, literary and historical transcendence and the canon. It is a comparative approach to two anthological modes (the anthology made by an anthologist-editor and the author's anthology) as means of diffusion and projection of the literary work. A partir de l'analyse d'une anthologie panoramique et d'une autoanthologie de l'œuvre poétique d’Andrés Sánchez Robayna, nous réfléchissons dans ce travail aux questions liées à la poétique de l'anthologie, la représentativité, la transcendance littéraire et historique et le canon. Il s'agit d'une approche comparative de deux modes anthologiques (l'anthologie réalisée par un anthologiste-éditeur et l'anthologie de l'auteur) comme moyen de diffusion et de projection de l'œuvre littéraire.
Leer a Andrés Sánchez Robayna en compañía de Jaime Siles: extraña coincidencia o des-coincidencia familiar. Para una hermenéutica de la hospitalidad
Authors: Castro Idoli 
Published: March 2018

Este artículo intenta aproximarse a las obras de Jaime Siles et de ASR no tanto comparándolas sino manifestando, desde la perspectiva poética y po-ética, los momentos de coincidencia y de des-coincidencia, conceptos teorizados por el filósofo francés François Jullien. La «entrada en la materia» (J. A. Valente) sensible y elemental (en el sentido merleau-pontiano) de ambas voces «intercorpóreas» es sin duda el momento de mayor coincidencia, abocando al camino de la ecocrítica. Al plasmar una reversibilidad de lo visible y de lo invisible, ambas obras participan de una definición de la poesía como precaria (Jérôme Thélot), poesía concebida como aquella toma de medida heideggeriana entre el cielo y la tierra, forma de habitar el mundo que incita a cada hombre a pedir lo imposible. Sin embargo, la carencia implicada en esa precariedad poética abre paradójicamente la vía de un posible pensamiento crítico de la hospitalidad, singularmente eco-poético y/o ecopo-ético. Cet article tente d’approcher les œuvres de Jaime Siles et d’ASR moins dans une perspective comparatiste que dans une volonté de manifester, tant en termes de poétique que de po-éthique, les moments de coïncidence et de décoïncidence, concepts que nous empruntons au philosophe français François Jullien. L’« entrée dans la matière » (J. A. Valente) sensible et élémentaire (dans le sens merleau-pontien) de ces deux voix « intercorporelles » s’avère sans doute le moment de plus grande coïncidence, nous conduisant ainsi sur le chemin de l’écocritique. Incarnant une réversibilité du visible et de l’invisible, ces deux œuvres participent d’une définition de la poésie comme précaire (Jérôme Thélot), poésie conçue comme cette prise de mesure heideggérienne entre le ciel et la terre, cette habitation du monde qui pousse tout homme à demander l’impossible. Toutefois, la carence qu’implique cette précarité poétique ouvre paradoxalement la voie d’une possible pensée critique de l’hospitalité, singulièrement éco-poétique et/ou écopo-éthique.
Traducir y ser traducido: el taller de traducción literaria de La Laguna y Kiel, y "Sobre una confidencia del mar griego" en alemán
Authors: Gómez-Montero Javier , Bischoff Christina Johanna 
Published: March 2018

Este díptico se abre con un texto de Javier Gómez-Montero que esboza una semblanza del Taller de Traducción Literaria de La Laguna dirigido por Andrés Sánchez Robayna, recordando líneas maestras de su concepto de traducción como creación literaria e hitos especialmente significativos de esta importante iniciativa para las letras hispánicas. La contribución principal, de Christina Johanna Bischoff, da cuenta de la traducción al alemán de Sobre una confidencia del mar griego, precedido de Correspondencias, de Andrés Sánchez Robayna. Partiendo de un breve análisis de aspectos poéticos y poetológicos claves, se presentan las metas y algunos problemas clave de dicha traducción. Dieses Diptychon umfasst zwei Beiträge. Javier Gómez-Montero stellt die von Andrés Sánchez Robayna geleitete Übersetzerwerkstatt La Laguna (Taller de Traducción Literaria de La Laguna) vor, skizziert Sánchez Robaynas Konzept einer als literarische Schöpfung zu verstehenden Übersetzung und benennt die Meilensteine dieser für die spanische Literatur bedeutenden Initiative. Einen Schwerpunkt bildet sodann der Beitrag von Christina Johanna Bischoff, der über die deutsche Übersetzung von Sobre una confidencia del mar griego und Correspondencia von Andrés Sáchez Robayna berichtet. Ausgehend von einer knappen Analyse poetisch-poetologischer Aspekte der beiden Sammlungen werden die Zielsetzungen der Übersetzung vorgestellt und konkrete Übersetzungsprobleme erörtert.
Auditoría integral a los procesos administrativos y financieros de pyme. Experiencias en el caso cooperativa de ahorro y crédito “El sol de los Andes” (Ecuador)
Authors: Ruiz Alvarado Priscila Isabel 
Published: March 2018

Las Cooperativas de Ahorro y Crédito en el Ecuador, en la provincia y el cantón Cañar han tenido un notable crecimiento en los últimos cinco años se ha evidenciado la apertura de un considerable número de ellas en la ciudad, lideradas por grupos o asociaciones indígenas del Cañar o del norte del país, generando desarrollo y crecimiento en las actividades productivas en la cabecera cantonal así como en las comunidades campesinas.
Para nuestro estudio se ha considerado el caso de una de ellas que para este artículo la denominaremos “Cooperativa de Ahorro y Crédito el “Sol de los Andes”, ya que por la confidencialidad que conllevan los informes de auditoría no se puede revelar la identidad del ente auditado.
Esta Cooperativa se crea por iniciativa de 15 migrantes el 31 de mayo del 2011 y desde esa fecha ha ido creciendo y ajustándose a los cambios en cuanto a las leyes, regulaciones y condiciones del entorno a las cuales se ha enfrentado.
La realización de una auditoría integral al proceso de ahorros programados de la institución financiera servirá de una herramienta de mejora y crecimiento ya que se enfoca a cuatro aspectos fundamentales de accionar administrativo y financiero.
Incidencia de los impuestos prediales en los ingresos municipales del Gobierno Autónomo Descentralizado Municipal del Cantón Sucúa, en los períodos 2014 y 2015
Authors: Lopez Jara Ana Alexandra , Calle Alvarado Marcelo Alejandro 
Published: March 2018

Esta investigación de naturaleza descriptiva y de tipo explicativa, detalla el origen del impuesto predial con su hecho generador, la reincidencia de la recaudación y el destino de los recursos provenientes del impuesto. El objetivo es analizar la variación existente y el impacto producto de la reinversión de dichos recursos en beneficio de los contribuyentes del cantón Sucúa en los periodos 2014 y 2015. Para efectos de la investigación se analizaron en términos administrativos y financieros los resultados económicos y de gestión del Gobierno Autónomo Descentralizado del Cantón Sucúa, a través un trabajo de campo: empleando los estados financieros, las cedulas presupuestarias y el Plan Operativo Anual del periodo investigado. Entre los resultados se conoce que el destino de los recursos obtenidos de los impuestos prediales se ubica en el mejoramiento de la calidad de vida de los habitantes al incentivar la cultura, la preservación del patrimonio cultural y el impulso del turismo, siendo este un beneficio de goce colectivo.