bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intra-rater and inter-rater reliability of the fixed plumb line for postural and scoliosis assessment in the sagittal plane: a pilot study
Authors: Roggio Federico , Trovato Bruno , Sortino Martina , Zanghì Marta , Di Brigida Claudio , Guglielmino Claudia , Lombardo Claudia , Loreto Carla , Pavone Piero , Musumeci Giuseppe 
Published: November 2024

Background
The plumb line (PL) is a common tool for assessing the sagittal curvatures of the spine, but its accuracy depends on the ability of the physician to use it correctly. This study aimed to present a fixed plumb line (FPL) no longer held by a physician but fixed to a support, evaluating the reliability in posture assessment, comparing it with PL in both adolescent with and without scoliosis.

Methods
The study evaluated the sagittal distances of the spine using a PL and a FPL in 80 young adults aged between 28.7 ± 7.2 and 55 adolescents aged between 12.4 ± 2.3, with and without scoliosis. Two expert and two novice clinicians tested the patients to evaluate the intra-rater and inter-rater reliability of FPL. Each clinician assessed participants twice on the same day, with a predetermined time interval (>1 h) to reduce recall bias. Multi-factor multivariate analysis of variance and two-way analysis of variance assessed the statistical significance, while intraclass correlation coefficient (ICC), standard error of measurement (SEM) and minimum detectable change (MDC) validated FPL consistency.

Results
FPL provided an ICC coefficient >0.90 for all the measures, while PL an average of 0.70. On AIS patients, PL and FPL showed a significant difference for C7 p < 0.001 and T12 p < 0.001. The measured parameters were sensitive to gender and age for the FPL, furthermore, the C7 and L3 measurements were statistically different between PL and FPL (p < 0.001). Intra-rater reliability results for FPL ranged from 0.94 to 0.98 across various parameters, while the SEM and MDC values underscore the valuable precision of the FPL with changes exceeding 1 cm being meaningful. These findings suggest that FPL could be a reliable and accurate tool for measuring sagittal distances of the spine in both scoliotic and non-scoliotic patients.
Intention to use short messaging services for promoting drug adherence among individuals with diabetes in Addis Ababa, Ethiopia
Authors: Alem Solomon , Gulema Hanna 
Published: November 2024

Background
Suboptimal medication adherence among individuals with diabetes presents a significant challenge in low-income nations. Growing evidence demonstrates the effectiveness of text messaging interventions to enhance medication adherence. This study assesses the intention to use Short Messaging Service (SMS) based reminder services in promoting drug adherence among diabetic patients and associated factors in Addis Ababa, Ethiopia.

Methods
An institution-based cross-sectional study was conducted from February 06, 2023, to March 27, 2023, in Addis Ababa, Ethiopia. A sample of 351 patients was selected using systematic random sampling. Structured questionnaires were used for data collection. Binary and multivariable logistic regression models were used to analyze the association between intention to use SMS reminders to promote drug adherence among individuals with diabetes and related factors.

Results
A total of 333 respondents, with a 94.87% response rate, were interviewed for this study. The majority of respondents, 66.4 % (95% CI [61.9–71.2]), expressed an intention to use SMS-based reminder services to promote their drug adherence. Age < 45 years (AOR = 5.73, 95% CI [2.07–15.73]), higher educational level (AOR = 3.03, 95% CI [1.16–7.90]), type of diabetes (AOR = 3.71, 95% CI [1.16–7.90]), oral medication users (AOR = 2.99, 95% CI [1.42–6.32]), SMS as a preferred medium for communication (AOR = 2.86, 95% CI [1.17–7.00]) were deemed to be important variables linked to intention to use SMS reminders to promote drug adherence among individuals with diabetes.

Conclusion
The findings suggest the majority of individuals with diabetes have intention to use SMS reminders to enhance adherence. This result indicates the potential for utilization of SMS reminders to enhance adherence to diabetic medications. Furthermore, the findings highlight the importance of tailored interventions that take into account patient characteristics and preferences as factors that influence intention when designing such an intervention.
Effect of vitamin C injections on exercise muscular performance and biochemical parameters in Trichinella spiralis-infected mice
Authors: Rashed Hadeer Abd El-hak , Albogami Bander , Alkhaldi Abdulsalam A. M. , Abuzinadah Najlaa Y. , Abuzahrah Samah S. , Al-Salmi Fawziah A. , Fayad Eman , Fouad Rewan Mohamed , Fikry Manar Elsayed , ElSaey Abd-Allah Ahmed , Abu Almaaty Ali Hussein 
Published: November 2024

Background
Trichinella spiralis is a worldwide intestinal nematode that can parasitize the striated muscles of its hosts at the larval stage. This study aims to evaluate potential of vitamin C for treating trichinellosis-related pathological problems in the infected muscles of mice.

Materials and Methods
Thirty CD1 male Albino mice were divided into three groups (10 mice per group). Negative and positive control groups (0.9% NaCl) and the infected vitamin C group (10 mg/kg body weight). Two weeks post-infection, each group was intraperitoneally injected daily for two weeks with Vitamin C or saline. The performance of the muscles was assessed both before and after the treatment. After dissection, constant parts of striated muscles were removed for further assays. The scoring of the histological changes of infected muscles was carried out. In addition to muscle malondialdehyde levels, superoxide dismutase and catalase activities were measured for the oxidative and antioxidant states. Creatine kinase and aspartate aminotransferase were also measured in tissues to reflect the degree of muscular damage.

Results
Vitamin C enhances the weakness of the muscular performance resulting from the infection. Vitamin C was able to repair some of the histological lesions that resulted from the infection. Trichinellosis caused severe changes in the biochemical markers in positive control animals. Muscle damage biomarkers and, besides, oxidative and antioxidant conditions were greatly ameliorated in infected vitamin C animals. Summing up, vitamin C can be used as a complementary drug due to its efficiency in improving pathogenesis following a trichinellosis infection. The supplement also must be tested in the intestinal stage of infection after showing promising results in the muscular stage.
The CLEC3B inhibits cellular proliferation and metastasis of cholangiocarcinoma through Wnt/β-catenin pathway
Authors: Wu Shengze , Wang Guangfeng , Xie Yuwei , Wu Tingting , Du Fangqian , Jin Chen , Dong Bingzi , Zhu Chengzhan 
Published: November 2024

Purpose
Cholangiocarcinoma (CCA) is a cancer of the biliary system, including intrahepatic and extrahepatic cholangiocarcinoma, and is highly aggressive. C-type lectins family member 3b (CLEC3B) is a Ca2+ binding transmembrane protein with different biological functions in a variety of cancers. The objective of this study was to explore the biological function of CLEC3B in CCA.

Methods
The CLEC3B gene was identified using the TCGA database and survival analysis of the cholangiocarcinoma clinical cohort. The expression CLEC3B cholangiocarcinoma and correlation with prognosis was investigated in our patient cohort. The effects of CLEC3B on proliferation, apoptosis, migration and invasion were verified in QBC939 and HUCCT1 cells. The effect of CLEC3B on the tumor formation was proved by xenograft tumor model in nude mice. The signaling pathway of CLEC3B in regulating CCA progression was further analyzed RNA sequencing and western blot.

Results
CLEC3B was decreased in the cholangiocarcinoma in the database. The mRNA and protein expression level of CLEC3B were significantly lower and correlated with poor overall survival in cholangiocarcinoma of our patient cohort. In vitro experiments proved that overexpression of CLEC3B can inhibit proliferation, migration and invasion in bile duct cancer cells. The CLEC3B was correlated with epithelial–mesenchymal transition and apoptosis. The calcium could promote the biological function of CLEC3B. The vivo study indicated that CLEC3B inhibited tumor formation. RNA sequencing indicating CLEC3B may transduce signal through e Wnt/β-catenin signaling pathway.

Conclusions
The CLEC3B inhibits cellular proliferation and migration of cholangiocarcinoma through the Wnt/β-catenin pathway.
Comparing the effectiveness of five traditional Chinese exercises in improving balance function in older adults: a systematic review and Bayesian network meta-analysis
Authors: Xie Jingyi , Guo Jindong , Wang Bin 
Published: November 2024

Background
Despite numerous studies affirming the potential of traditional Chinese exercises (TCEs) in enhancing balance in older adults, systematic integration is lacking. This study evaluated the effectiveness of five TCEs—Baduanjin, Liuzijue, Tai Chi, Wuqinxi, and Yijinjing—in improving balance among older adults using network meta-analysis.

Methods
This meta-analysis was registered in PROSPERO with the registration number CRD42023481450. Related articles indexed by Web of Science, Cochrane, PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases before October 2023 were searched. Randomized controlled trials (RCTs) involving TCEs interventions to improve balance function conducted in older adults who aged ≥60 years were included. Two researchers used Review Manager to assess the quality of the studies, and analyzed the data using Stata and R.

Results
In total, 46 RCTs and 3,333 older adults were included. The aforementioned TCEs had positive effects on improving balance in older adults. Tai Chi revealed significant intervention effects in performing the Single-Leg Stand with eyes Closed (SLSC), 6-Min Walk Test (6MWT), and Short Form 36-Item Physical Component Summary (SF-36PCS). Liuzijue significantly improved performance in the Timed Up and Go Test (TUGT), 6MWT, SF-36PCS, and Berg Balance Scale (BBS). Baduanjin, Wuqinxi, and Yijinjing showed noteworthy intervention effects on the BBS. Tai Chi ranked highest in the SLSC, 6MWT, and SF-36PCS in the surface under the cumulative ranking, while Liuzijue and Yijinjing ranked highest in the TUGT and BBS, respectively.

Conclusion
Tai Chi, Liuzijue, and Yijinjing improved the static, dynamic, and overall balance outcomes, respectively. Older adults can make a reasonable choice among these TCEs based on their needs.
Morphological Characterization and Production Performance of Begait Sheep Breed in Tigrai, Ethiopia
Authors: Gebremariam Teklehaimanot Tsigab , Mengesha Yosef Tadese , Gebretsadik Zelealem Tesfay 
Published: November 2024

This study was conducted in two districts of Tigray region, northern Ethiopia in 510 animals from 144 small holder farmers aimed to estimate morphological parameters and evaluate production traits, and inbreeding levels in Begait sheep. Data were collected between 2019 and 2022 and analyzed using descriptive statistics of SPSS V20 and GLM of SAS V9.1 for the qualitative data and linear body measurements respectively. Large muscular body frame, long thin tail, markedly convex facial profile were distinctive features of Begait sheep population with predominantly plain (49.80%) coat color followed by plain (44.51%) and spotted (5.69 %) of various colors. Of the total Begait sheep, white with black patchy (49.00%) was the most frequent coat color followed by white (33.33%), light red (7.45%) and fawn (4.31%). The population has relatively heavy live body weight and large body size with a mean live body weight of 55.76 ±0.70kg and 42.40 ±0.36kg for males and females respectively, which indicates the potential of the population for meat production. GLM revealed almost all the morphometric measurements were significantly (p < 0.05) different among districts, sexes and age groups of Sheep. The higher body weights (49.22 ±1.09 kg) and most other linear body measurements were also recorded in the age group of three pair of permanent incisors (3PPI), whereas the lower values (41.49 ±0.85 kg for body weight) were recorded in the age group of one pair of permanent incisors (1PPI) and bdy weight was significantly correlated (P<0.01) with linear body measurements with the correlation coefficients ranging from 0.069 - 0.768. Begait sheep are known as early maturing and prolific breed with Twin (39.66%) and triple (0.98%) births. To concluded Begait sheep may possess unique adaptive features that should be useful and considered in designing and implementing a sustainable sheep improvement program.
The Role of Herbivore-Induced Plant Volatiles in Tri-trophic Interactions and Pest Management
Authors: S. M Kishore , Khajuria Marvi , K.V. L Supraja , Srija P. , K. S. N Manideep , G Harideep , Morabad Parvati B 
Published: November 2024

In agricultural ecosystems, the tri trophic interactions between plants, herbivores and their natural enemies are crucial for maintaining ecological balance and crop health. Natural enemies of pests predominantly regulate herbivore populations, emphasizing the importance of these interactions. Plants exhibit both induced and constitutive defences, Plants use herbivore-induced plant volatiles (HIPVs) as a key mechanism to attract natural enemies that defend them against the herbivores. HIPVs are chemical signals emitted in response to herbivore damage and can attract predators and parasitoids, indirectly they protect the plants. This review explores the role of HIPVs in plant defense, focusing on their evolutionary, chemical and practical aspects. with HIPVs acting as indirect defenses by recruiting natural enemies. The interaction between physical traits, chemical signals and semiochemicals, including volatile organic compounds (VOCs), significantly influences these interactions. Olfactometers, such as the Y-tube and four-arm designs, have been proven to be pivotal in studying insect responses to these volatile compounds, providing insights into their behavior and effectiveness in pest management. Despite advances in understanding HIPVs, research indicates variability in volatile emissions and their effectiveness across different herbivore species and developmental stages. Further studies are needed to improve the specificity of HIPV research, incorporating field-based analyses to capture natural environmental complexities. Future research should focus on optimizing HIPV applications in pest management, understanding spatial and temporal scales of HIPV interactions, and addressing the influence of environmental factors on HIPV efficacy.
Dosimetric effects of a repositioning head frame system and treatment planning system dose calculation accuracy
Authors: Ferrer Carlos , Huertas Concepción , Plaza Rodrigo , Aza Zulima , Corredoira Eva 
Published: September 2018

AbstractThis work aims to study the effect on surface dose and dose distribution caused by the Elekta Fraxion cranial immobilization system. The effect of Fraxion inclusion in Elekta Monaco treatment planning system and its calculation accuracy is also checked. To study the dose attenuation, a cylindrical phantom was located over the Elekta Fraxion with an IBA CC13 ionization chamber placed in the central insert at the linac isocenter. Dose measurements at multiple gantry angles were performed for three open fields, 10 × 10 cm, 5 × 5 cm and other smaller 2 × 2 cm. Measured doses were compared with the ones calculated by Monaco. Surface dose and dose distribution in the buildup region were measured placing several Gafchromic Films EBT3 at linac CAX between the slabs of a RW3 phantom located over Fraxion and read using FilmQA Pro software. Measures were performed for two open field sizes and results were compared with Monaco calculations. Measurements show a 1% attenuation for 180° gantry angle but it can be as high as 3.4% (5 × 5 open field) for 150°/210° gantry angle, as with these angles the beam goes through the Fraxion's headrest twice. If Fraxion is not included in the calculation Monaco calculation can result in a 3% difference between measured and calculated doses, while with Fraxion in the calculation, the maximum difference is 0.9%. Fraxion increases 3.7 times the surface dose, which can be calculated by Monaco with a difference lower than 2%. Monaco also calculated correctly the PDD for both open fields (2%) when Fraxion is included in the calculation. This work shows that the attenuation varies with gantry angle. The inclusion of Fraxion in Monaco improves the calculation from 3% difference to 1% in the worst case. Furthermore, the surface dose increment and the dose in the buildup region are correctly calculated.
3D Printing Fiber Electrodes for an All‐Fiber Integrated Electronic Device via Hybridization of an Asymmetric Supercapacitor and a Temperature Sensor
Authors: Zhao Jingxin , Zhang Yan , Huang Yinan , Xie Jixun , Zhao Xiaoxin , Li Chaowei , Qu Jingyi , Zhang Qichong , Sun Juan , He Bing , Li Qiulong , Lu Conghua , Xu Xinhua , Lu Weibang , Li Liqiang , Yao Yagang 
Published: September 2018

AbstractWearable fiber‐shaped electronic devices have drawn abundant attention in scientific research fields, and tremendous efforts are dedicated to the development of various fiber‐shaped devices that possess sufficient flexibility. However, most studies suffer from persistent limitations in fabrication cost, efficiency, the preparation procedure, and scalability that impede their practical application in flexible and wearable fields. In this study, a simple, low‐cost 3D printing method capable of high manufacturing efficiency, scalability, and complexity capability to fabricate a fiber‐shaped integrated device that combines printed fiber‐shaped temperature sensors (FTSs) with printed fiber‐shaped asymmetric supercapacitors (FASCs) is developed. The FASCs device can provide stable output power to FTSs. Moreover, the temperature responsivity of the integrated device is 1.95% °C−1.
Evaluation value of neutrophil gelatinase‐associated lipocalin for the renal dysfunction of patients with chronic kidney disease: A meta‐analysis
Authors: Guo Lulu , Zhao Yaya , Yong Zhenzhu , Zhao Weihong 
Published: September 2018

AbstractObjectiveThe role of neutrophil gelatinase‐associated lipocalin (NGAL) for the evaluation of renal function in chronic kidney disease (CKD) has not yet to be determined. We aimed to perform a meta‐analysis exploring the correlation between NGAL and glomerular filtration rate (GFR) in CKD patients, and to further identify factors affecting NGAL's performance.MethodsStudies dated before November 2017 were retrieved from PubMed, Embase, Web of Science, and the Cochrane Library. A total of 28 relevant studies (involving 3082 patients from 17 countries) were included. The second version of the Quality Assessment for Studies of Diagnostic Accuracy demonstrated that no significant bias had influenced the methodological quality of the included studies.ResultsNeutrophil gelatinase‐associated lipocalin showed a strong negative correlation with measured glomerular filtration rate (mGFR). The pooled correlation coefficient (r) with corresponding 95% confidence intervals for the correlation between serum NGAL (sNGAL) and GFR was −0.48, meanwhile that for urine NGAL (uNGAL) and GFR was −0.34. However, NGAL's performance is different in subgroups restricted by clinical settings, race, sex, age, and staging of renal function.ConclusionNeutrophil gelatinase‐associated lipocalin could be a renal function evaluation marker for patients with renal dysfunction in CKD. Compared with uNGAL, there was a significant negative correlation between sNGAL and GFR. The performances of sNGAL and uNGAL were restricted by clinical factors that should be considered in regards to the sampling source selection.
B(C6F5)3/Amine‐Catalyzed C(sp)−H Silylation of Terminal Alkynes with Hydrosilanes: Experimental and Theoretical Studies
Authors: Ma Yuanhong , Lou Shao‐Jie , Luo Gen , Luo Yong , Zhan Gu , Nishiura Masayoshi , Luo Yi , Hou Zhaomin 
Published: September 2018

AbstractTransition metal catalyzed C−H functionalization of organic compounds has proved to be a useful atom‐efficient strategy in organic synthesis. In contrast, main‐group‐element‐based catalytic processes for C−H functionalization have remained underexplored to date. Reported herein is the catalytic C(sp)−H silylation of a wide range of terminal alkynes with hydrosilanes by using a combination of B(C6F5)3 and an organic base such as triethylenediamine (DABCO). This protocol constitutes the first example of boron‐catalyzed C(sp)−H functionalization, offering a convenient route for the synthesis of a variety of alkynylsilanes. Experimental and computational studies have revealed that DABCO plays two crucial roles (Lewis base and Brønsted base) in this catalytic transformation.
Asymmetric Enzymatic Hydration of Unactivated, Aliphatic Alkenes
Authors: Demming Rebecca M. , Hammer Stephan C. , Nestl Bettina M. , Gergel Sebastian , Fademrecht Silvia , Pleiss Jürgen , Hauer Bernhard 
Published: September 2018

AbstractThe direct enantioselective addition of water to unactivated alkenes could simplify the synthesis of chiral alcohols and solve a long‐standing challenge in catalysis. Here we report that an engineered fatty acid hydratase can catalyze the asymmetric hydration of various terminal and internal alkenes. In the presence of a carboxylic acid decoy molecule for activation of the oleate hydratase from E. meningoseptica, asymmetric hydration of unactivated alkenes was achieved with up to 93 % conversion, excellent selectivity (>99 % ee, >95 % regioselectivity), and on a preparative scale.
Novel bioactive porous starch–siloxane matrix for bone regeneration: Physicochemical, mechanical, and in vitro properties
Authors: Aidun Amir , Zamanian Ali , Ghorbani Farnaz 
Published: September 2018

AbstractSo far, many studies have focused on biodegradable scaffolds for tissue engineering purposes. Herein, a starch‐based biodegradable scaffold was fabricated by the freeze‐drying method and cross‐linked using a different concentration of 3‐glycidoxypropyl‐trimethoxysilane (GPTMS). Field emission scanning electron microscopy (FE‐SEM) micrographs indicated an interconnected porous microstructure in which the porosity decreased as a function of starch and GPTMS content. Increasing the mechanical stability and decreasing absorption capacity and biodegradation ratio affected by the higher concentration of cross‐linker and the changes in structure as a function of cross‐linker enhancement. Moreover, the mineralization of hybrid structures in simulated body fluid was proved by FE‐SEM image and X‐ray diffraction analysis. Results indicated the more GPTMS in scaffolds led to more hydroxyapatite formation. The ability of the growth and proliferation of bone marrow mesenchyme stem cells on the constructs confirmed the ability of scaffolds for bone tissue engineering applications.