bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of stable sources of resistance to mungbean yellow mosaic virus (MYMV) disease in mungbean [Vigna radiata (L.) Wilczek]
Authors: Nagaraj  , Basavaraj S , Padmaja A.S. , Nagaraju N , Ramesh S 
Published: May 2019

AbstractYellow mosaic disease (YMD) caused by mungbean yellow mosaic virus (MYMV) is one of the most destructive biotic production constraints in mungbean. Development and introduction of resistant cultivars are considered as the most economical and eco-friendly option to manage YMD, for which availability of stable sources of resistance is a pre-requisite. A set of 14 mungbean genotypes including a susceptible check were evaluated for responses to YMD under natural infection across three seasons and under challenged inoculation in glasshouse for one season. None of the genotypes were immune to YMD and produced different degrees of response to MYMV in terms of yellow mosaic symptoms (YMS). Based on the delayed appearance of initial YMS, and lower estimates of per cent disease index and area under disease progressive curve (AUDPC) in response to natural infection and challenged inoculation, five genotypes namely AVMU 1698, AVMU 1699, AVMU 16100, AVMU 16101 and KPS 2 were identified as resistant to YMD. Failure of detection of MYMV through polymerase chain reaction (PCR) using MYMV coat protein gene-specific primer and successful detection of the same through rolling circle amplification-PCR suggested latent infection of MYMV in resistant genotypes. The resistance response of the five genotypes could be attributed to enhanced activities of enzymes such as peroxidase, polyphenol oxidase and phenylalanine ammonia lyase and increased concentration of total phenols. These results are discussed in relation to strategies to breed mungbean for resistance to YMD.
Push–pull configuration of high-power MOSFETs for generation of nanosecond pulses for electropermeabilization of cells
Authors: Davies I. W. , Merla C. , Casciati A. , Tanori M. , Zambotti A. , Mancuso M. , Bishop J. , White M. , Palego C. , Hancock C. P. 
Published: May 2019

AbstractA power MOSFET-based push–pull configuration nanosecond-pulse generator has been designed, constructed, and characterized to permeabilize cells for biological and medical applications. The generator can deliver pulses with durations ranging from 80 ns up to 1 µs and pulse amplitudes up to 1.4 kV. The unit has been tested for in vitro experiments on a medulloblastoma cell line. Following the exposure of cells to 100, 200, and 300 ns electric field pulses, permeabilization tests were carried out, and viability tests were conducted to verify the performance of the generator. The maximum temperature rise of the biological load was also calculated based on Joule heating energy conservation and experimental validation. Our results indicate that the developed device has good capabilities to achieve well-controlled electro-manipulation in vitro.
Wired warfare 3.0: Protecting the civilian population during cyber operations
Authors: Schmitt Michael N. 
Published: May 2019

AbstractAs a general matter, international humanitarian law is up to the task of providing the legal framework for cyber operations during an armed conflict. However, two debates persist in this regard, the resolution of which will determine the precise degree of protection the civilian population will enjoy during cyber operations. The first revolves around the meaning of the term “attack” in various conduct of hostilities rules, while the second addresses the issue of whether data may be considered an object such that operations destroying or altering it are subject to the prohibition on attacking civilian objects and that their effects need be considered when considering proportionality and the taking of precautions in attack. Even if these debates were to be resolved, the civilian population would still face risks from the unique capabilities of cyber operations. This article proposes two policies that parties to a conflict should consider adopting in order to ameliorate such risks. They are both based on the premise that military operations must reflect a balance between military concerns and the interest of States in prevailing in the conflict.
Maternal folic acid depletion during early pregnancy increases sensitivity to squamous tumor formation in the offspring in mice
Authors: Kawakubo-Yasukochi Tomoyo , Morioka Masahiko , Ohe Kenji , Yasukochi Atsushi , Ozaki Yasuhiko , Hazekawa Mai , Nishinakagawa Takuya , Ono Kazuhiko , Nakamura Seiji , Nakashima Manabu 
Published: May 2019

AbstractGestational nutrition is widely recognized to affect an offspring’s future risk of lifestyle-related diseases, suggesting the involvement of epigenetic mechanisms. As folic acid (FA) is a nutrient essential for modulating DNA methylation, we sought to determine how maternal FA intake during early pregnancy might influence tumor sensitivity in an offspring. Dams were maintained on a FA-depleted (FA(−)) or normal (2 mg FA/kg; FA(+)) diet from 2 to 3 days before mating to 7 days post-conception, and their offspring were challenged with chemical tumorigenesis using 7,12-dimethylbenz[a)anthracene and phorbol 12-myristate 13-acetate for skin and 4-nitroquinoline N-oxide for tongue. In both squamous tissues, tumorigenesis was more progressive in the offspring from FA(−) than FA(+) dams. Notably, in the skin of FA(−) offspring, the expression and activity of cylindromatosis (Cyld) were decreased due to the altered DNA methylation status in its promoter region, which contributed to increased tumorigenesis coupled with inflammation in the FA(−) offspring. Thus, we conclude that maternal FA insufficiency during early pregnancy is able to promote neoplasm progression in the offspring through modulating DNA methylation, such as Cyld. Moreover, we propose, for the first time, “innate” utero nutrition as the third cause of tumorigenesis besides the known causes—hereditary predisposition and acquired environmental factors.
Characterization of multiple herbicide–resistant waterhemp (Amaranthus tuberculatus) populations from Illinois to VLCFA-inhibiting herbicides
Authors: Strom Seth A. , Gonzini Lisa C. , Mitsdarfer Charlie , Davis Adam S. , Riechers Dean E. , Hager Aaron G. 
Published: May 2019

AbstractField experiments were conducted in 2016 and 2017 in Champaign County, IL, to study a waterhemp [Amaranthus tuberculatus(Moq.) J. D. Sauer] population (CHR) resistant to 2,4-D and 4-hydroxyphenylpyruvate dioxygenase (HPPD)-, photosystem II–, acetolactate synthase (ALS)-, and protoporphyrinogen oxidase–inhibiting herbicides. Two field experiments were designed to investigate the efficacy of very-long-chain fatty-acid (VLCFA)-inhibiting herbicides, including a comparison of active ingredients at labeled use rates and a rate titration experiment.Amaranthus tuberculatusdensity and control were evaluated at 28 and 42 d after treatment (DAT). Nonencapsulated acetochlor, alachlor, and pyroxasulfone provided the greatest PRE control of CHR (56% to 75%) at 28 DAT, while metolachlor,S-metolachlor, dimethenamid-P, and encapsulated acetochlor provided less than 27% control. In the rate titration study, nonencapsulated acetochlor controlled CHR more than equivalent field use rates ofS-metolachlor. Subsequent dose–response experiments with acetochlor,S-metolachlor, dimethenamid-P, and pyroxasulfone in the greenhouse included three multiple herbicide–resistant (MHR)A. tuberculatuspopulations: CHR-M6 (progeny generated from CHR), MCR-NH40 (progeny generated from Mclean County, IL), and ACR (Adams County, IL), in comparison with a sensitive population (WUS). Both CHR-M6 and MCR-NH40 are MHR to atrazine and HPPD, and ALS inhibitors and demonstrated higher survival rates (LD50) toS-metolachlor, acetochlor, dimethenamid-P, or pyroxasulfone than ACR (atrazine resistant but HPPD-inhibitor sensitive) and WUS. Based on biomass reduction (GR50), resistant to sensitive (R:S) ratios between CHR-M6 and WUS were 7.5, 6.1, 5.5, and 2.9 forS-metolachlor, acetochlor, dimethenamid-P, and pyroxasulfone, respectively. Values were greater for MCR-NH40 than CHR-M6, and ACR was the most sensitive to all VLCFA inhibitors tested. Complete control of all populations was achieved at or below a field use rate of acetochlor. In summary, field studies demonstrated CHR is not controlled by several VLCFA-inhibiting herbicides. Greenhouse dose–response experiments corroborated field results and generated R:S ratios (LD50) ranging from 4.5 to 64 for CHR-M6 and MCR-NH40 among the four VLCFA-inhibiting herbicides evaluated.
Characterization of the phenotypic variability in Colombian weedy rice (Oryza spp.)
Authors: Hoyos Veronica , Plaza Guido , Caicedo Ana L. 
Published: May 2019

AbstractWeedy rice (Oryza spp.) is considered one of the main weeds in cultivated rice (Oryza sativa L.) around the world, having a great impact on both yield and quality of crop rice. Recent studies have characterized the range of morphological and genetic diversity in weedy rice from different locations and have revealed that there is often great morphological diversity within growing regions. No systematic attempt to characterize phenotypic diversity of weedy rice in Colombia, where this group of weeds greatly affects rice production, has yet been carried out. This study seeks (1) to establish the range of variation in various morphological characters for weedy rice collected in the five production zones of Colombia and to compare these with commercial varieties and landraces sown in the country, (2) to determine the association between weedy rice morphotypes and rice production areas in the country, and (3) to assess whether any association exists between morphology and recently discovered genetic groupings for weedy rice in Colombia. Based on a sampling of rice production areas in Colombia and evaluation of 27 phenotypic traits, a two-step cluster analysis identified four morphological groups for weedy rice in Colombia. These groupings had some limited association with geography and the genetic ancestries of weedy rice. Clustering showed that awn and apiculus color and awn length and presence are the most important predictors in defining morphological groupings. Understanding and classifying the morphological diversity may be helpful in understanding weedy rice origins, evolution, and potential management practices.
The Role of Personality in Becoming Aware of Age-Related	Changes
Authors: Rupprecht Fiona S. , Dutt Anne J. , Wahl Hans-Werner , Diehl Manfred K. 
Published: May 2019

Abstract. Awareness of age-related change (AARC) refers to an individual’s conscious knowledge about the gains and losses resulting from growing older. Personality traits reflect dispositional patterns of behavior, perception, and evaluation and should therefore influence the experience of AARC. The 4.5-year longitudinal study examines this association between personality traits and AARC in a sample of 423 individuals aged 40 to 98 years ( M = 62.9 years) using latent change analyses. After controlling for sex, health, and education, a different pattern of associations emerged for cross-sectional vs. longitudinal relations. Cross-sectionally, neuroticism was positively related to AARC losses, whereas openness, conscientiousness, and neuroticism were positively related to AARC gains. Longitudinally, the impact of personality traits on change in AARC was rather limited with only higher conscientiousness acting as a predictor of decreases in AARC losses over time. Overall, the findings add to the existing literature on associations between personality traits and subjective aging. Specifically, the results indicate that personality traits are differentially related to awareness of age-related gains in comparison to awareness of age-related losses.
Subtropical‐Tropical Transfer in the South Atlantic Ocean
Authors: Cabré A. , Pelegrí J. L. , Vallès‐Casanova I. 
Published: May 2019

AbstractHere we explore the water transfer between the subtropical and tropical gyres of the South Atlantic Ocean to better understand its unique equatorward heat delivery. A Lagrangian technique is applied to the reanalysis product GLORYS2V4 in order to trace back the western boundary flow in the tropical (North Brazil Undercurrent, NBUC) and subtropical (Brazil Current) gyres. Most of the northward NBUC core transport (14.9 Sv at 8°S) arrives from the eastern boundary subtropical current (Benguela Current) via the zonal South Equatorial Current. This subtropical‐tropical transfer represents the core of the returning limb of the Atlantic meridional overturning circulation and accounts for most of the observed increase in heat and salt‐volume transports (0.18 PW and 0.19 Sv from 30°S to 8°S, respectively) across the South Atlantic. The NBUC also includes Antarctic Intermediate Water below 400 m (7.4 Sv at 8°S) coming from the interior subtropical gyre, as well as water from the current's surface and peripheral components coming from the tropical gyre (13.3 Sv at 8°S). The Brazil Current (9.9 Sv at 29°S) is mostly composed of subtropical water originating in the upper 800 m west of the eastern boundary current at 30°S (8.5 Sv), with a minor contribution of surface tropical water that transfers to the subtropics (1.4 Sv).
A generative modeling approach for benchmarking and training shallow quantum circuits
Authors: Benedetti Marcello , Garcia-Pintos Delfina , Perdomo Oscar , Leyton-Ortega Vicente , Nam Yunseong , Perdomo-Ortiz Alejandro 
Published: May 2019

AbstractHybrid quantum-classical algorithms provide ways to use noisy intermediate-scale quantum computers for practical applications. Expanding the portfolio of such techniques, we propose a quantum circuit learning algorithm that can be used to assist the characterization of quantum devices and to train shallow circuits for generative tasks. The procedure leverages quantum hardware capabilities to its fullest extent by using native gates and their qubit connectivity. We demonstrate that our approach can learn an optimal preparation of the Greenberger-Horne-Zeilinger states, also known as “cat states”. We further demonstrate that our approach can efficiently prepare approximate representations of coherent thermal states, wave functions that encode Boltzmann probabilities in their amplitudes. Finally, complementing proposals to characterize the power or usefulness of near-term quantum devices, such as IBM’s quantum volume, we provide a new hardware-independent metric called the qBAS score. It is based on the performance yield in a specific sampling task on one of the canonical machine learning data sets known as Bars and Stripes. We show how entanglement is a key ingredient in encoding the patterns of this data set; an ideal benchmark for testing hardware starting at four qubits and up. We provide experimental results and evaluation of this metric to probe the trade off between several architectural circuit designs and circuit depths on an ion-trap quantum computer.
Upregulation of the NLRC4 inflammasome contributes to poor prognosis in glioma patients
Authors: Lim Jaejoon , Kim Min Jun , Park YoungJoon , Ahn Ju Won , Hwang So Jung , Moon Jong-Seok , Cho Kyung Gi , Kwack KyuBum 
Published: May 2019

AbstractInflammation in tumor microenvironments is implicated in the pathogenesis of tumor development. In particular, inflammasomes, which modulate innate immune functions, are linked to tumor growth and anticancer responses. However, the role of the NLRC4 inflammasome in gliomas remains unclear. Here, we investigated whether the upregulation of the NLRC4 inflammasome is associated with the clinical prognosis of gliomas. We analyzed the protein expression and localization of NLRC4 in glioma tissues from 11 patients by immunohistochemistry. We examined the interaction between the expression of NLRC4 and clinical prognosis via a Kaplan-Meier survival analysis. The level of NLRC4 protein was increased in brain tissues, specifically, in astrocytes, from glioma patients. NLRC4 expression was associated with a poor prognosis in glioma patients, and the upregulation of NLRC4 in astrocytomas was associated with poor survival. Furthermore, hierarchical clustering of data from the Cancer Genome Atlas dataset showed that NLRC4 was highly expressed in gliomas relative to that in a normal healthy group. Our results suggest that the upregulation of the NLRC4 inflammasome contributes to a poor prognosis for gliomas and presents a potential therapeutic target and diagnostic marker.
Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway
Authors: Benedikz Elizabeth K. , Bailey Dalan , Cook Charlotte N. L. , Gonçalves-Carneiro Daniel , Buckner Michelle M. C. , Blair Jessica M. A. , Wells Timothy J. , Fletcher Nicola F. , Goodall Margaret , Flores-Langarica Adriana , Kingsley Robert A. , Madsen Jens , Teeling Jessica , Johnston Sebastian L. , MacLennan Calman A. , Balfe Peter , Henderson Ian R. , Piddock Laura J. V. , Cunningham Adam F. , McKeating Jane A. 
Published: May 2019

AbstractViruses and bacteria colonize hosts by invading epithelial barriers. Recent studies have shown that interactions between the microbiota, pathogens and the host can potentiate infection through poorly understood mechanisms. Here, we investigated whether diverse bacterial species could modulate virus internalization into host cells, often a rate-limiting step in establishing infections. Lentiviral pseudoviruses expressing influenza, measles, Ebola, Lassa or vesicular stomatitis virus envelope glycoproteins enabled us to study entry of viruses that exploit diverse internalization pathways. Salmonella Typhimurium, Escherichia coli and Pseudomonas aeruginosa significantly increased viral uptake, even at low bacterial frequencies. This did not require bacterial contact with or invasion of host cells. Studies determined that the bacterial antigen responsible for this pro-viral activity was the Toll-Like Receptor 5 (TLR5) agonist flagellin. Exposure to flagellin increased virus attachment to epithelial cells in a temperature-dependent manner via TLR5-dependent activation of NF-ΚB. Importantly, this phenotype was both long lasting and detectable at low multiplicities of infection. Flagellin is shed from bacteria and our studies uncover a new bystander role for this protein in regulating virus entry. This highlights a new aspect of viral-bacterial interplay with significant implications for our understanding of polymicrobial-associated pathogenesis.
Growth hormone peak modifies the effect of BMI on increased systolic blood pressure in children with short stature
Authors: Li Yanying , Zhang Yanhong , Zhang Mei , Yang Wanling , Ji Baolan , Pan Hui , Ban Bo 
Published: May 2019

AbstractBlood pressure (BP), especially systolic BP (SBP), is higher in adult growth hormone deficiency (AGHD) patients than in normal controls. Additionally, obesity is a known risk factor for hypertension, and growth hormone deficiency (GHD) is an important cause of short stature. For children with GHD, attention has been directed solely towards height. Few studies have assessed its potential impact on BP. Here, we investigated the effect of body mass index standard deviation score (BMISDS) on BP in children with short stature. This study included 736 children with short stature divided into two groups based on peak growth hormone (GH) level in GH provocation tests [severe GHD (SGHD) group = 212 children; non-SGHD group = 524 children]. We found that SBP was significantly higher in the SGHD group than in the non-SGHD group (p = 0.045). Additionally, there was a significant positive association between BMISDS and SBP in the SGHD group (β = 3.12, 95% CI: 1.40–4.84, p < 0.001), but no association between these variables was observed in the non-SGHD group. Thus, SGHD patients had a higher SBP than non-SGHD patients. BMISDS is a significant factor for higher SBP in SGHD patients but not in non-SGHD patients.
Anisotropy of Percolation Threshold of BaTiO3-Ni0.5Zn0.5Fe2O4 Composite Films
Authors: Tang Yu , Wang Ruixin , Zhang Yi , Li Shun , Du Piyi 
Published: May 2019

AbstractA systematic study on the magnetic and electrical percolation phenomena of BaTiO3 (BTO)-NiZnF2O4 (NZFO) composite films is presented in this work with the purpose of simplifying the preparation process of high-performance 1–3-type multiferroic composite films. Results show that the percolation threshold of the composite films depends on the macroscopic dimension of the material. The low-dimensional nature of the composite films results in different percolation thresholds with topological transition in vertical and horizontal directions. BTO-NZFO composite films with a grain size of 15 nm and a thickness of 100 nm exhibited a percolation threshold of 0.18 in the normal direction and a percolation threshold of 0.48 in the horizontal direction. In light of this intriguing feature, a novel multiferroic composite film with 1–3 structure and strong magnetoelectric coupling was easily prepared by a 0–3 process via controlling the NZFO content in the region between two percolation thresholds.
Impact of renal dysfunction on the choice of diagnostic imaging, treatment strategy, and outcomes in patients with stable angina
Authors: Kato Takao , Uemura Yukari , Naya Masanao , Momose Mitsuru , Matsumoto Naoya , Suzuki Eriko , Hida Satoshi , Nakajima Takatomo , Yamauchi Takao , Tamaki Nagara 
Published: May 2019

AbstractWe investigated the interaction between the prognostic impact of a decrease in eGFR and the choice of initial diagnostic imaging modality for coronary artery disease. Out of 2878 patients who enrolled in the J-COMPASS study, 2780 patients underwent single photon emission computed tomography (SPECT), coronary computed tomography (CT) angiography, or coronary angiography (CAG) as an initial diagnostic test. After excluding patients with routine hemodialysis or lacked serum creatinine levels, 2096 patients in the non-decreased eGFR group (eGFR ≥ 60 ml/min/1.73 m2) and 557 patients in the decreased eGFR group (eGFR < 60 ml/min/1.73 m2) were analyzed in this study. Major adverse cardiac events, including death, myocardial infarction, heart failure hospitalization, and late revascularization, were followed, with a median follow-up duration of 472 days. SPECT or CAG was preferable to CT in patients in the decreased eGFR group (p < 0.0001 and p = 0.0024, respectively). There was a marginally significant interaction between the prognostic impact of a decrease in eGFR and the choice of diagnostic imaging modality (interaction-p = 0.056). A decrease in eGFR was not associated with a poor outcome in patients who underwent CT, while a decrease in eGFR was associated with poor outcomes in patients who underwent SPECT or CAG. In conclusion, the prognostic impact of a decrease in eGFR tended to be different among the initial imaging modalities.