bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transfer of the human telomerase reverse transcriptase(TERT) gene into T lymphocytes results in extension of replicative potential
Authors: Rufer Nathalie , Migliaccio Marco , Antonchuk Jennifer , Humphries R. Keith , Roosnek Eddy , Lansdorp Peter M. 
Published: July 2002

AbstractIn most human somatic cells telomeres progressively shorten with each cell division eventually leading to chromosomal instability and cell senescence. The loss of telomere repeats with cell divisions may also limit the replicative life span of antigen-specific T lymphocytes. Recent studies have shown that the replicative life span of various primary human cells can be prolonged by induced expression of the telomerase reverse transcriptase (hTERT) gene. To test whether introduction of hTERT can extend the life span of primary human T lymphocytes, naive CD8+ T lymphocytes were transfected with retroviral vectors containing the hTERTgene. Transduced T-cell clones expressed high levels of telomerase and either maintained or elongated their telomere lengths upon culture for extended periods of time. Two of the transduced subclones retained a normal cloning efficiency for more than 170 population doublings (PDs). In contrast, T-cell clones transfected with control vectors exhibited progressive telomere length shortening and stopped proliferation at around 108 PDs. Telomerase-positive T clones had a normal 46,XY karyotype, maintained their cytotoxic properties, and showed very little staining for the apoptotic marker annexin-V. These results indicate that ectopic hTERT gene expression is capable of extending the replicative life span of primary human CD8+cytotoxic T lymphocytes.
Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis
Authors: Kaser Arthur , Brandacher Gerald , Steurer Wolfgang , Kaser Susanne , Offner Felix A. , Zoller Heinz , Theurl Igor , Widder Walter , Molnar Clemens , Ludwiczek Othmar , Atkins Michael B. , Mier James W. , Tilg Herbert 
Published: July 2002

AbstractBaseline platelet production is dependent on thrombopoietin (TPO). TPO is constitutively produced and primarily regulated by receptor-mediated uptake by platelets. Inflammatory thrombocytosis is thought to be related to increased interleukin-6 (IL-6) levels. To address whether IL-6 might act through TPO to increase platelet counts, TPO was neutralized in vivo in C57BL/10 mice treated with IL-6, and hepatic TPO mRNA expression and TPO plasma levels were studied. Transcriptional regulation of TPO mRNA was studied in the hepatoblastoma cell line HepG2. Furthermore, TPO plasma levels were determined in IL-6–treated cancer patients. It is shown that IL-6–induced thrombocytosis in C57BL/10 mice is accompanied by enhanced hepatic TPO mRNA expression and elevated TPO plasma levels. Administration of IL-6 to cancer patients results in a corresponding increase in TPO plasma levels. IL-6 enhances TPO mRNA transcription in HepG2 cells. IL-6–induced thrombocytosis can be abrogated by neutralization of TPO, suggesting that IL-6 induces thrombocytosis through TPO. A novel pathway of TPO regulation by the inflammatory mediator IL-6 is proposed, indicating that the number of platelets by themselves might not be the sole determinant of circulating TPO levels and thus of thrombopoiesis. This regulatory pathway might be of relevance for the understanding of reactive thrombocytosis.
Social Determinants of Health and Language and Academic Outcomes in Pediatric Cochlear Implantation
Authors: Mueller Lauren , Adkins Dean , Kao Allison , Munyemana Marie-Ange , Kallogjeri Dorina , Lieu Judith E. 
Published: November 2024

ImportanceCochlear implants can restore sound and enable speech and language development for children with severe to profound sensorineural hearing loss. Long-term outcomes of pediatric cochlear implant recipients are variable. Although the association between social determinants of health (SDH) and pediatric cochlear implant outcomes has been explored, the strength of this association has not been quantitatively synthesized in the literature.ObjectiveTo determine the association of SDH with language and academic outcomes in pediatric cochlear implant recipients.Data SourcesIn August 2023, the following databases were searched: Embase.com, Ovid MEDLINE, Scopus, Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, Cumulated Index to Nursing and Allied Health Literature Plus, APA PsycINFO, and ClinicalTrials.gov. Following duplicate exclusion of 8687 results, 5326 records were finalized.Study SelectionAbstract screening, full-text review, and risk of bias assessment was performed by 1 to 2 reviewers. Articles were included if an effect size for an SDH variable that was associated with measures of language, communication, reading, academics, and quality of life was reported.Main Outcomes and MeasuresA random-effects meta-analysis was performed, with standardized regression coefficients measuring the relative direction and magnitude of a variable association with the outcome of interest.ResultsOf 5326 articles, 40 articles that included a total of 3809 children were included in the systematic review; 20 articles that included a total of 1905 children were included in the meta-analysis. Parental involvement, education level, and low socioeconomic status were moderately to strongly associated with language outcomes (β = 0.30; 95% CI, 0.13-0.48; β = 0.45; 95% CI, 0.29-0.62; β = −0.47; 95% CI, −0.83 to −0.10, respectively). Known determinants of language outcomes, such as the age of cochlear implantation and duration of cochlear implant use, demonstrated moderate to no associations with language outcomes (β = −0.30; 95% CI, −0.43 to −0.17; β = 0.19; 95% CI, −0.26 to 0.63, respectively).Conclusions and RelevanceThe results of this systematic review and meta-analysis suggest that SDH are associated with childhood language development and academic achievement. In addition to efforts to expedite cochlear implant placement in eligible children, optimal outcomes may be achieved with interventions centered on the child’s home, primary medical care, and school environment.
Unusual Antibacterial Property and Selectivity Enabled by Tuning Nanozyme Activities of L‐Arginine Derived Carbon Dots
Authors: Yu Meizhe , Li Peili , Li Jiaying , Chen Xueli , Hu Zhimin , Wang Yiran , Zeng Jing , Han Fengxuan , Gong Xuedong , Li Bin , Xing Xiaodong 
Published: November 2024

AbstractFunctional integration of antimicrobial activity and cell proliferation promotion at low concentrations is important for the clinical application of carbon dots (CDs). In this study, the precursor, L‐arginine, and dopant, copper salt, are used to prepare copper‐doped CDs (Cu‐CDs). Owing to their excellent synergistic enzyme‐like activities, Cu‐CDs can rapidly increase reactive oxygen species (ROS) to lethal levels, preferentially in bacteria, and exhibit potent antibacterial ability, which can mainly be attributed to the membrane disruption effect. Concurrently, the cell proliferation‐promoting activity of arginine‐derived CDs is inherited. The Cu‐CDs achieve perfect integration of dual functions at low concentrations, especially advantageous for applications. With as little as 100 µg mL−1 of Cu‐CDs, the infected wound heals obviously faster than 2 mg mL−1 of antibiotic, although the traditional antibiotic group shows slightly better antibacterial efficiency, suggesting its effect in simultaneously scavenging bacteria and promoting tissue repair effect in vivo. The super selective mechanism probably originates from the endocytosis of Cu‐CDs by mammalian cells, while superoxide dismutase down‐regulates ROS levels in cells to act as a mitotic signaling agent for promoting cell growth. This strategy provides an efficient, convenient, and safe solution to combat bacterial infections, and suggests a novel approach for modifying antimicrobial biomaterials.
Gigahertz Modulation of a Fully Dielectric Nonlocal Metasurface
Authors: Pitanti Alessandro , Da Prato Gaia , Biasiol Giorgio , Tredicucci Alessandro , Zanotto Simone 
Published: November 2024

AbstractNonlocal metasurfaces are currently emerging as advanced tools for the manipulation of electromagnetic radiation, going beyond the widely explored Huygens metasurface concept. Nonetheless, the lack of an unified approach for their fast and efficient tunability still represents a serious challenge to overcome. This study reports on the gigahertz modulation of a dielectric slab‐based, nonlocal (i.e., angle‐dispersive) metasurface, whose operation relies on the optomechanical coupling with a mechanical wave excited piezoelectrically by a transducer integrated on the same chip. Importantly, the metasurface region is free from any conductive material, thus eliminating optical losses, and making the device of potential interest for delicate environments such as high‐power apparatuses or quantum optical systems.
Thermally Activated Delayed Fluorescent Organic Light Emitting Diodes: Solution Processed to Printed
Authors: Cole Cameron M. , Yambem Soniya D. 
Published: November 2024

AbstractOrganic light emitting diodes (OLEDs) have progressed immensely, enabled by the different generations of light emitting materials. The latest generation of light emitting materials for OLEDs are the thermally activated delayed fluorescent (TADF) emitters and there has been significant effort in making solution processable TADF emitters, which has led to printable TADF OLEDs. This review provides an analysis of the current state‐of‐the‐art solution processed TADF OLEDs including white‐OLEDs. We find that fully solution processed TADF OLEDs, where all the organic layers are solution processed, account for only ≈4% of the reported solution processed TADF OLEDs. We also evaluate the progress of printed TADF OLEDs, examining the state‐of‐the‐art performances, different emissive materials and the similarities and differences in the device structures used. Our analysis reveals that the majority of the printing for TADF OLEDs is through inkjet printing and their emission peaks predominantly fall within the 500 nm to <600 nm. We conclude with proposals of potential areas for further research for the development of cheaper and scalable OLEDs.
Fine‐Tuning Porous Structure of Zirconium‐Based Metal–Organic Frameworks for Efficient Separation and Purification of Astaxanthin by Defect Engineering
Authors: Na Xin , Xing Shanghua , Tan Mingqian , Su Wentao 
Published: November 2024

AbstractEfficient separation of bioactive compounds from nature source, particularly that of astaxanthin (AXT), remains challenging due to their low content in complicated matrix and readily degradable structure. Herein, a modulator‐induced defect engineering is presented on the stable zirconium‐based metal–organic frameworks (Zr‐MOFs) to optimize pore size and pore chemistry for the efficient separation and purification of AXT for the first time. High adsorption capacity of 26.21 mg g−1 is achieved on the best‐performing defect Zr‐MOF (d‐UiO‐67‐4), superior over the other reported adsorbent for AXT. Meanwhile, d‐UiO‐67‐4 exhibits the selective adsorption of AXT over other carotenoids analogues with similar structure and properties. This is attributed to the preferential non‐covalent interactions between defect framework and AXT revealed by the spectroscopy analysis and density functional theory (DFT) calculations. High purity of AXT with 89.0% ± 2.3% extraction efficiency can be realized after the purification of AXT by d‐UiO‐67‐4. The practical separation performance of d‐UiO‐67‐4 for AXT extracted from Haematococcus pluvialis is demonstrated by fixed‐bed column‐based dynamic adsorption and desorption experiments. This work broadens the preparation methods for thermosensitive active substances and provided new research ideas for the controlled adsorption of functional food factors.
Jammed Pickering Emulsion Gels
Authors: Zhang Jia , Zheng Yuan , Guo Baoling , Sun Dongpeng , Xiao Yao , Yang Ze , Liu Rongrong , Chen Jingyi , Wu Baiheng , Zhao Peng , Ruan Jian , Weitz David A , Chen Dong 
Published: November 2024

AbstractEmulsion gels with specific rheological properties have widespread applications in foods, cosmetics, and biomedicines. However, the constructions of water‐in‐oil emulsion gels are still challenging, due to the limited interactions available in the continuous oil phase. Here, a versatile strategy is developed to prepare a new type of emulsion gels, called Jammed Pickering emulsion gels (JPEGs). In the JPEG system, SiO2 NPs in the oil phase serve as colloidal surfactants to stabilize water‐in‐oil Pickering emulsions, while positively‐charged NH2‐PEG‐NH2 molecules in the water phase cross‐link negatively‐charged SiO2 NPs at the water/oil interface, making NP‐stabilized water droplets hard to deform and thus jamming the emulsion system to form emulsion gels. The strategy to prepare JPEGs is versatile and applicable to diverse oil phases. The designed JPEGs possess many advantages, including good biocompatibility for widespread applications, shear‐thinning rheological properties for easy processing, good stability Over a wide temperature range and Against centrifugation, good adhesion to wet tissues for tissue engineering, and well‐controlled sustained release Under intestinal conditions. The developed JPEGs are demonstrated to be a promising delivery platform and the strategy to achieve JPEGs will trigger more innovations of material design.
Retina‐Inspired X‐Ray Optoelectronic Synapse Using Amorphous Ga2O3 Thin Film
Authors: Liang Huili , Tang Xiaoyan , Shao Hang , Zhu Rui , Deng Shizhi , Zhan Xiaozhi , Zhu Tao , Wang Jiwei , Zhang Jihua , Zhang Guangyu , Mei Zengxia 
Published: November 2024

AbstractMachine vision techniques are widely applied for object identification in daily life and industrial production, where images are captured and processed by sensors, memories, and processing units sequentially. Neuromorphic optoelectronic synapses, as a preferable option to promote the efficiency of image recognition, are hotly pursued in non‐ionizing radiation range, but rarely in ionizing radiation including X‐rays. Here, the study proposes an X‐ray optoelectronic synapse using amorphous Ga2O3 (a‐Ga2O3) thin film. Boosted by the interfacial VO2+ defects and its slow neutralization rate, the enhanced electron tunneling process at metal/a‐Ga2O3 interface produces remarkable X‐ray‐induced post‐synaptic current, contributing to a sensitivity of 20.5, 64.3, 164.1 µC mGy−1 cm−2 for the 1st, 5th, and 10th excitation periods, respectively. Further, a 64 × 64 imaging sensor is constructed on a commercial amorphous Si (a‐Si) thin film transistor (TFT) array. The image contrast can be apparently improved under a series of X‐ray pulses due to an outstanding long‐term plasticity of the single pixel, which is beneficial to the subsequent image recognition and classification based on artificial neural network. The merits of large‐scale production ability and good compatibility with modern microelectronic techniques belonging to amorphous oxide semiconductors may promote the development of neuro‐inspired X‐ray imagers and corresponding machine vision systems.
Emerging Spatiotemporal Dynamics in Multiterminal Neuromorphic Nanowire Networks Through Conductance Matrices and Voltage Maps
Authors: Pilati Davide , Michieletti Fabio , Cultrera Alessandro , Ricciardi Carlo , Milano Gianluca 
Published: November 2024

AbstractSelf‐organizing memristive nanowire (NW) networks are promising candidates for neuromorphic‐type data processing in a physical reservoir computing framework because of their collective emergent behavior, which enables spatiotemporal signal processing. However, understanding emergent dynamics in multiterminal networks remains challenging. Here experimental spatiotemporal characterization of memristive NW networks dynamics in multiterminal configuration is reported, analyzing the activation and relaxation of network's global and local conductance, as well as the inherent spatial nonlinear transformation capabilities. Emergent effects are analyzed i) during activation, by investigating the spatiotemporal dynamics of the electric field distribution across the network through voltage mapping; ii) during relaxation, by monitoring the evolution of the conductance matrix of the multiterminal system. The multiterminal approach also allowed monitoring the spatial distribution of nonlinear activity, demonstrating the impact of different network areas on the system's information processing capabilities. Nonlinear transformation tasks are experimentally performed by driving the network into different conductive states, demonstrating the importance of selecting proper operating conditions for efficient information processing. This work allows a better understanding of the local nonlinear dynamics in NW networks and their impact on the information processing capabilities, providing new insights for a rational design of self‐organizing neuromorphic systems.
Irrigation frequency effects on Prizm zoysiagrass establishment from sprigs
Authors: Carr Tyler Q. , Sorochan John C. , Brosnan James, T. , Horvath Brandon J. , Walters Kellie. J. 
Published: November 2024

AbstractZoysiagrass (Zoysia spp. Willd.) is a popular choice for commercial and residential lawns, as well as golf course fairways and tees because it requires less light, fertilizer, and mowing compared to bermudagrass (Cynodon spp.). However, zoysiagrass' slow growth rate compared to other putting green options presents a challenge for both rapid establishment from sprigs and its wider adoption as a putting green surface. It is currently unknown if very frequent irrigation, commonly used in horticultural propagation, can be applied to turfgrass and accelerate establishment from sprigs. Irrigation was applied to Prizm zoysiagrass sprigs across either four or 192 irrigation events from 06:00 a.m. to 10:00 p.m. Prizm zoysiagrass establishment was unaffected by irrigation frequency and averaged 40% turfgrass coverage after 21.6 and 27.3 days in run A and run B, respectively. These results imply that very frequent irrigation did not accelerate establishment. Additional research elucidating zoysiagrass sprig physiology during propagation and development is necessary to better define management practices that hasten establishment.
Comparison of Sport Type on the Handgrip Strength Change in Young Athletes
Authors: Abe Takashi , Abe Akemi , Loenneke Jeremy P. 
Published: November 2024

ABSTRACTObjectiveWhether or not an athlete plays with sports equipment in their hands may influence handgrip strength (HGS) changes during development, but longitudinal studies have not confirmed this. This study compared one‐year HGS changes between two sports types (soccer vs. kendo) in children and adolescent athletes.MethodsOne hundred sixty‐eight young athletes (86 kendo boys and 82 soccer boys) had two HGS measurements separated by 1 year. A 2 (sports) by 2 (timepoints 1 and 2) repeated measures ANOVA was used to determine whether HGS changed differently between sports.ResultsThere was no evidence for a sport × time interaction in HGS (p = 0.14); however, the mean difference and 95% CI were in the direction of favoring a greater change in kendo athletes [difference of 0.6 (95% CI: −0.2, 1.5) kg]. There was a main effect of time and sport. Kendo athletes had a 4.6 (95% CI: 1.8, 7.5) kg greater HGS than soccer athletes. There was no evidence that the change in HGS between sports depended on the initial age of the athlete (p = 0.205).ConclusionUsing sports equipment during play may positively affect HGS.
Microwave‐Assisted Synthetic Pathways of Pyrrole: A Comprehensive Review
Authors: Yadav Ritika , Sanduja Mohit , Kumar Vinod , Sharma Kirti , Khan Sameer , Kumar Kapil 
Published: November 2024

AbstractMicrowave synthesis is a sustainable and eco‐friendly method for producing novel organic compounds, offering faster reactions, higher yields, and improved purity compared to traditional techniques. Efficiency is increased by the uniform heating caused by microwave radiation, especially for the synthesis of heterocyclic compound and their derivatives. Owing to have important biological and therapeutic qualities, a number of microwave‐assisted synthetic methods of pyrroles have been developed that produce better results than the conventional reported method. In view of this, the present review emphasizes solvent‐free and catalyst‐free methods for the microwave‐assisted synthesis of pyrrole and its fusion with other heterocycles such as furan, pyridine, beta‐lactam, and indole. A comparison between traditional and microwave‐assisted techniques is given in terms of reagents, covering yield, waste minimization, solvents, and catalysts.
Additive effects of cerebrovascular disease functional connectome phenotype and plasma p‐tau181 on longitudinal neurodegeneration and cognitive outcomes
Authors: Chong Joanna Su Xian , Ji Fang , Hilal Saima , Chong Joyce Ruifen , Lau Jia Ming , Tong Nathanael Ren Jie , Tan Boon Yeow , Venketasubramanian Narayanaswamy , Lai Mitchell Kim Peng , Chen Christopher Li‐Hsian , Zhou Juan Helen 
Published: November 2024

AbstractINTRODUCTIONWe investigated the effects of multiple cerebrovascular disease (CeVD) neuroimaging markers on brain functional connectivity (FC), and how such CeVD‐related FC changes interact with plasma phosphorylated tau (p‐tau)181 (an Alzheimer's disease [AD] marker) to influence downstream neurodegeneration and cognitive changes.METHODSMultivariate associations among four CeVD markers and whole‐brain FC in 529 participants across the dementia spectrum were examined using partial least squares correlation. Interactive effects of CeVD‐related FC patterns and p‐tau181 on longitudinal gray matter volume (GMV) and cognitive changes were investigated using linear mixed‐effects models.RESULTSWe identified a brain FC phenotype associated with high CeVD burden across all markers. Further, expression of this general CeVD‐related FC phenotype and p‐tau181 contributed additively, but not synergistically, to baseline and longitudinal GMV and cognitive changes.DISCUSSIONOur findings suggest that CeVD exerts global effects on the brain connectome and highlight the additive nature of AD and CeVD on neurodegeneration and cognition.Highlights
Effects of multiple cerebrovascular disease (CeVD) markers on functional connectivity were studied.
A global network phenotype linked to high burden across CeVD markers was identified.
CeVD phenotype and plasma phosphorylated tau 181 contributed additively to downstream outcomes.
One‐Step Esterification of Phosphoric, Phosphonic and Phosphinic Acids with Organosilicates: Phosphorus Chemical Recycling of Sewage Waste
Authors: Naganawa Yuki , Sakamoto Kei , Fujita Akira , Morimoto Kazuya , Ratanasak Manussada , Hasegawa Jun‐ya , Yoshida Masaru , Sato Kazuhiko , Nakajima Yumiko 
Published: November 2024

AbstractGlobal concerns regarding the depletion and strategic importance of phosphorus resources have increased demand for the recovery and recycling. However, waste‐derived phosphorus compounds, primarily as chemically inert phosphoric acid or its salts, present a challenge to their direct conversion into high‐value chemicals. We aimed to develop an innovative technology that utilizes the large quantities of sewage waste, bypasses the use of white phosphorus, and enables esterification of phosphoric acid to produce widely applicable phosphate triesters. Tetraalkyl orthosilicates emerged as highly effective reagents for the direct triple esterification of 85 % phosphoric acid, as well as the esterification of organophosphinic and phosphonic acids. Furthermore, we achieved esterification of recovered phosphoric acid with tetraalkyl orthosilicate, thus pioneering a recycling pathway from sewage waste to valuable phosphorus chemicals. Experimental and theoretical investigations revealed a novel mechanism, wherein tetraalkyl orthosilicates facilitate multimolecular aggregation to achieve alkyl transfer from tetraalkylorthosilicate to phosphoric acid via multiple proton shuttling.