bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic accuracy of the Geriatric Depression Scale-30, Geriatric Depression Scale-15, Geriatric Depression Scale-5 and Geriatric Depression Scale-4 for detecting major depression: protocol for a systematic review and individual participant data meta-analysis
Authors: Benedetti Andrea , Wu Yin , Levis Brooke , Wilchesky Machelle , Boruff Jill , Ioannidis John P A , Patten Scott B , Cuijpers Pim , Shrier Ian , Gilbody Simon , Ismail Zahinoor , McMillan Dean , Mitchell Nicholas , Ziegelstein Roy C , Thombs Brett D 
Published: December 2018

IntroductionThe 30-item Geriatric Depression Scale (GDS-30) and the shorter GDS-15, GDS-5 and GDS-4 are recommended as depression screening tools for elderly individuals. Existing meta-analyses on the diagnostic accuracy of the GDS have not been able to conduct subgroup analyses, have included patients already identified as depressed who would not be screened in practice and have not accounted for possible bias due to selective reporting of results from only better-performing cut-offs in primary studies. Individual participant data meta-analysis (IPDMA), which involves a standard systematic review, then a synthesis of individual participant data, rather than summary results, could address these limitations. The objective of our IPDMA is to generate accuracy estimates to detect major depression for all possible cut-offs of each version of the GDS among studies using different reference standards, separately and among participant subgroups based on age, sex, dementia diagnosis and care settings. In addition, we will use a modelling approach to generate individual participant probabilities for major depression based on GDS scores (rather than a dichotomous cut-off) and participant characteristics (eg, sex, age, dementia status, care setting).Methods and analysisIndividual participant data comparing GDS scores to a major depression diagnosis based on a validated structured or semistructured diagnostic interview will be sought via a systematic review. Data sources will include Medline, Medline In-Process & Other Non-Indexed Citations, PsycINFO and Web of Science. Bivariate random-effects models will be used to estimate diagnostic accuracy parameters for each cut-off of the different versions of the GDS. Prespecified subgroup analyses will be conducted. Risk of bias will be assessed with the Quality Assessment of Diagnostic Accuracy Studies-2 tool.Ethics and disseminationThe findings of this study will be of interest to stakeholders involved in research, clinical practice and policy.PROSPERO registration numberCRD42018104329.
Serum sodium changes in marathon participants who use NSAIDs
Authors: Whatmough Steven , Mears Stephen , Kipps Courtney 
Published: December 2018

IntroductionThe primary mechanism through which the development of exercise-associated hyponatraemia (EAH) occurs is excessive fluid intake. However, many internal and external factors have a role in the maintenance of total body water and non-steroidal anti-inflammatory medications (NSAIDs) have been implicated as a risk factor for the development of EAH. This study aimed to compare serum sodium concentrations ([Na]) in participants taking an NSAID before or during a marathon (NSAID group) and those not taking an NSAID (control group).MethodsParticipants in a large city marathon were recruited during race registration to participate in this study. Blood samples and body mass measurements took place on the morning of the marathon and immediately post marathon. Blood was analysed for [Na]. Data collected via questionnaires included athlete demographics, NSAID use and estimated fluid intake.ResultsWe obtained a full data set for 28 participants. Of these 28 participants, 16 took an NSAID on the day of the marathon. The average serum [Na] decreased by 2.1 mmol/L in the NSAID group, while it increased by 2.3 mmol/L in the control group NSAID group (p=0.0039). Estimated fluid intake was inversely correlated with both post-marathon serum [Na] and ∆ serum [Na] (r=−0.532, p=0.004 and r=−0.405 p=0.032, respectively).ConclusionSerum [Na] levels in participants who used an NSAID decreased over the course of the marathon while it increased in those who did not use an NSAID. Excessive fluid intake during a marathon was associated with a lower post-marathon serum [Na].
Surgical plantaris tendon removal for patients with plantaris tendon-related pain only and a normal Achilles tendon: a case series
Authors: Alfredson Håkan , Masci Lorenzo , Spang Christoph 
Published: December 2018

ObjectivesSurgical removal of the plantaris tendon can cure plantaris-associated Achilles tendinopathy, a condition in which Achilles and plantaris tendinopathy coexist. However, rare cases with plantaris tendinopathy alone are often misdiagnosed due to a normal Achilles tendon.Design and settingProspective case series study at one centre.ParticipantsTen consecutive patients (9 men and one woman, mean age 35 years, range 19–67) with plantaris tendon-related pain alone in altogether 13 tendons were included. All had had a long duration (median 10 months, range 3 months to 10 years) of pain symptoms on the medial side of the Achilles tendon mid-portion. Preoperative ultrasound showed thickened plantaris tendon but a normal Achilles tendon.InterventionsOperative treatment consisting of ultrasound-guided excision of the plantaris tendon.Primary and secondary outcome measuresScores from Victorian Institute of Sports Assessment-Achilles questionnaire (VISA-A)were taken preoperatively and postoperatively (median duration 10 months). Patient satisfaction and time until full return to sports activity level was asked by a questionnaire.ResultsThe VISA-A scores increased from 61 (range 45–81) preoperatively to 97 (range 94–100) postoperatively (p<0.01). Follow-up results at 10 months (range 7–72 months) on 9/10 patients showed full satisfaction and return to their preinjury sports or recreational activityConclusionThe plantaris tendon should be kept in mind when evaluating painful conditions in the Achilles tendon region, especially when no Achilles tendinopathy is present. Excision of the plantaris tendon via a minor surgical procedure in local anaesthesia results in a good outcome.
Cardiovascular drugs attenuated myocardial resistance against ischaemia-induced and reperfusion-induced injury in a rat model of repetitive occlusion
Authors: Gatzke Nora , Güc Nadija , Hillmeister Philipp , Dülsner André , Le Noble Ferdinand , Buschmann Eva Elina , Ingwersen Maja , Bramlage Peter , Buschmann Ivo R 
Published: December 2018

ObjectiveWe investigated the impact of cardioprotective drugs on ST-elevation, arrhythmias and infarct size in a rat model of repetitive coronary artery occlusion.MethodsSeventy Sprague-Dawley rats were randomised to two control and five treatment groups. Placebo was either implantation of a pneumatic occluder onto the left anterior descending coronary artery (LAD) without starting repetitive occlusion (SHAM) or subsequent RO of the LAD over 10 days without medication (ROP). Treatment groups underwent RO and additionally received nitroglycerin (NTG), metoprolol, verapamil (VER), ranolazine (RAN) or candesartan (CAN). Two weeks after the intervention, rats underwent a single, sustained LAD occlusion followed by reperfusion. To evaluate differences in cardiac resistance against myocardial ischaemia and reperfusion injury, cardiac surrogate parameters including maximal ST-elevation, arrhythmias and infarct size were assessed.ResultsCompared with sham, RO alone and RO plus nitroglycerin were associated with significantly lower maximal ST-elevation and percentage of infarcted myocardium (SHAM 0.12 mV, ROP 0.06 mV (p=0.004), NTG 0.05 mV (p=0.005); SHAM 16.2%, ROP 6.6% (p=0.008), NTG 5.9% (p=0.006). Compared with RO alone, RO plus RAN was accompanied by increased ST-elevation (0.13 mV, p=0.018) and RO plusVER or CAN by more infarcted myocardium (14.2%, p=0.004% and 15.5%, p=0.003, respectively). Rats treated with VER, RAN or CAN tended to severe arrhythmias more frequently than those of the control groups.ConclusionsRO led to an increased myocardial resistance against ischaemia and reperfusion injury. Concomitant administration of nitroglycerin did not affect the efficacy of RO. Cardiovascular channel or receptor blockers reduced the efficacy of RO.
Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease
Authors: Minamisawa Masatoshi , Koyama Jun , Kozuka Ayako , Miura Takashi , Saigusa Tatsuya , Ebisawa Soichiro , Motoki Hirohiko , Okada Ayako , Ikeda Uichi , Kuwahara Koichiro 
Published: December 2018

ObjectiveMyocardial early systolic lengthening (ESL) duration is prolonged in patients with coronary artery disease (CAD). However, the relationship between the fractional flow reserve (FFR), the current gold standard for evaluating physiological myocardial ischaemia, and ESL has not been studied. The aims of this study were to investigate whether left ventricular (LV) ESL duration could identify patients with CAD, and to examine the relationship between FFR and LV ESL duration.MethodsIn this single-centre, cross-sectional, prospective study of 75 patients with suspected or known CAD, we performed two-dimensional speckle tracking echocardiography at rest on the day before coronary angiography or percutaneous coronary intervention. Apical 3 views were used to examine ESL duration, defined as time from onset of the Q wave to maximum myocardial systolic lengthening.ResultsThirty-five patients had non-significant stenosis. Forty patients with CAD underwent FFR testing: 17 had an FFR≥0.8 and 23 had an FFR<0.8. Global ESL duration was 20.9±22.2 ms in patients with non-significant stenosis, 36.4±23.2 ms in patients with FFR≥0.8 and 39.6±29.5 ms in patients with FFR<0.8 (p=0.020). However, global and regional ESL durations were not significantly correlated with FFR and demonstrated poor reproducibility.ConclusionAlthough myocardial ESL duration was significantly prolonged in patients with CAD compared with patients without CAD, ESL at rest showed poor reproducibility, and this new parameter did not predict FFR in patients with suspected CAD.
Effects of exercise and physical activity promotion: meta-analysis informing the 2018 EULAR recommendations for physical activity in people with rheumatoid arthritis, spondyloarthritis and hip/knee osteoarthritis
Authors: Rausch Osthoff Anne-Kathrin , Juhl Carsten Bogh , Knittle Keegan , Dagfinrud Hanne , Hurkmans Emalie , Braun Juergen , Schoones Jan , Vliet Vlieland Theodora P M , Niedermann Karin 
Published: December 2018

ObjectiveTo evaluate the effectiveness of exercise and physical activity (PA) promotion on cardiovascular fitness, muscle strength, flexibility, neuromotor performance (eg, balance) and daily PA in people with rheumatoid arthritis (RA), spondyloarthritis (SpA) and hip/knee osteoarthritis (HOA/KOA).Methodssystematic review (SR) and meta-analysis (MA) were performed searching the databases PubMed/Medline, CENTRAL, Embase, Web of Science, Emcare and PsycInfo until April 2017. We included randomised controlled trials (RCTs) in adults (≥18 years) with RA, SpA and HOA/KOA, investigating the effects of exercise or PA promotion according to the public health PA recommendations by the American College of Sports Medicine. The time point of interest was the first assessment after the intervention period. If suitable, data were pooled in a MA using a random-effects model presented as standardised mean difference (SMD).ResultsThe SR included 63 RCTs, of which 49 (3909 people with RA/SpA/HOA/KOA) were included in the MA. Moderate effects were found of aerobic exercises and resistance training on cardiovascular fitness (SMD 0.56 (95% CI 0.38 to 0.75)) and muscle strength (SMD 0.54 (95% CI 0.35 to 0.72)), respectively, but no effect of combined strength/aerobic/flexibility exercises on flexibility (SMD 0.12 (95% CI -0.16 to 0.41)). PA promotion interventions produced a small increase in PA behaviour (SMD 0.21 (95% CI 0.03 to 0.38)).ConclusionExercises and PA promotion according to public health recommendations for PA improved cardiovascular fitness, muscle strength and PA behaviour, with moderate effect sizes in people with SpA, RA and HOA/KOA.Trial registration numberCRD42017082131.
Eradication of Central Nervous System Leukemia of T-Cell Origin with a Brain-Permeable LSD1 Inhibitor
Authors: Saito Shiori , Kikuchi Jiro , Koyama Daisuke , Sato Shin , Koyama Hiroo , Osada Naoki , Kuroda Yoshiaki , Akahane Koshi , Inukai Takeshi , Umehara Takashi , Furukawa Yusuke 
Published: December 2018

Abstract

Purpose:
Lysine-specific demethylase 1 (LSD1) regulates several biological processes via the bifunctional modulation of enhancer functions. Recently, we reported that LSD1 overexpression is a founder abnormality of T-cell leukemogenesis and is maintained in fully transformed T-cell acute lymphoblastic leukemia (T-ALL) cells. On the basis of this finding, we attempted to develop novel LSD1 inhibitors effective for T-ALL with central nervous system (CNS) involvement.

Experimental Design:
We chemically modified the prototype LSD inhibitor tranylcypromine (TCP) and screened for cytotoxicity against TCP-resistant T-ALL cell lines. In vivo efficacy of novel LSD1 inhibitors was examined in immunodeficient mice transplanted with luciferase-expressing T-ALL cell lines, which faithfully reproduce human T-ALL with CNS involvement.

Results:
We found robust cytotoxicity against T-ALL cells, but not normal bone marrow progenitors, for two N-alkylated TCP derivatives, S2116 and S2157. The two compounds induced apoptosis in TCP-resistant T-ALL cells in vitro and in vivo by repressing transcription of the NOTCH3 and TAL1 genes through increased H3K9 methylation and reciprocal H3K27 deacetylation at superenhancer regions. Both S2116 and S2157 significantly retarded the growth of T-ALL cells in xenotransplanted mice and prolonged the survival of recipients as monotherapy and in combination with dexamethasone. Notably, S2157 could almost completely eradicate CNS leukemia because of its ability to efficiently pass through the blood–brain barrier.

Conclusions:
These findings provide a molecular basis and rationale for the inclusion of a brain-permeable LSD1 inhibitor, S2157, in treatment strategies for T-ALL with CNS involvement.
Preconception Exposure to Fine Particulate Matter Leads to Cardiac Dysfunction in Adult Male Offspring
Authors: Tanwar Vineeta , Adelstein Jeremy M. , Grimmer Jacob A. , Youtz Dane J. , Katapadi Aashish , Sugar Benjamin P. , Falvo Michael J. , Baer Lisa A. , Stanford Kristin I. , Wold Loren E. 
Published: December 2018

Background

Particulate matter (particles < 2.5 μm [
PM
2.5
]) exposure during the in utero and postnatal developmental periods causes cardiac dysfunction during adulthood. Here, we investigated the potential priming effects of preconception exposure of
PM
2.5
on cardiac function in adult offspring.

Methods and Results

Male and female friend leukemia virus b (FVB) mice were exposed to either filtered air (
FA
) or
PM
2.5
at an average concentration of 38.58 μg/m
3
for 6 hours/day, 5 days/week for 3 months. Mice were then crossbred into 2 groups: (1)
FA
male
×
FA
female
(both parents were exposed to
FA
preconception) and, (2)
PM
2.5male
×
PM
2.5female
(both parents were exposed to
PM
2.5
preconception). Male offspring were divided: (1) preconception
FA
(offspring born to
FA
exposed parents) and, (2) preconception
PM
2.5
(offspring born to
PM
2.5
exposed parents) and analyzed at 3 months of age. Echocardiography identified increased left ventricular end systolic volume and reduced posterior wall thickness, reduced %fractional shortening and %ejection fraction in preconception
PM
2.5
offspring. Cardiomyocytes isolated from preconception
PM
2.5
offspring showed reduced %peak shortening, −dL/dT,
TPS
90 and slower calcium reuptake (tau). Gene and protein expression revealed modifications in markers of inflammation (
IL
‐6,
IL
‐15,
TNF
α,
NF
қB,
CRP
,
CD
26E,
CD
26P, intercellular adhesion molecule 1, and monocyte chemoattractant protein‐1) profibrosis (collagen type III alpha 1 chain), oxidative stress (
NOS
2), antioxidants (Nrf2,
SOD
, catalase), Ca
2+
regulatory proteins (
SERCA
2a, p‐
PLN
,
NCX
), and epigenetic regulators (Dnmt1, Dnmt3a, Dnmt3b, Sirt1, and Sirt2) in preconception
PM
2.5
offspring.

Conclusions

Preconception exposure to
PM
2.5
results in global cardiac dysfunction in adult offspring, suggesting that abnormalities during development are not limited to the prenatal or postnatal periods but can also be determined before conception.
Taxonomic notes and Corrigendum for the manuscript entitled “Ichneumonid wasps of the subfamily Mesochorinae (Hymenoptera: Ichneumonidae): new replacement names, combinations and an updated key to the World genera” ARAUJO et al. (2018), Zootaxa, 4521: 052–060.
Authors: ARAUJO RODRIGO O. 
Published: December 2018

Mesochorinae is a widely distributed subfamily of ichneumonid wasps with approximately 900 described species (Yu et al., 2012), of which almost 90% belong to the cosmopolitan genus Mesochorus Gravenhorst (Broad et al., 2018). Since it is a very large genus, it has become a group of complex taxonomy and with numerous taxonomic conflicts (Araujo et al., 2018). Recent efforts were made aiming to resolve nomenclature problems present within Mesochorus (see Araujo & Vivallo, 2015; Kittel, 2016; Araujo et al. 2018). Specifically, Araujo & Vivallo (2015) and Araujo et al. (2018) proposed a total of 19 replacement names, of which two became primary homonyms of existing names (listed below) and seven were invalid, as Kittel (2016) and, in one case, Schwenke (2002), had previously proposed respective replacement names. Furthermore, Araujo et al. (2018) published an identification key for the World genera of Mesochorinae which includes Incurvarion Kasparyan. However, this genus was implicitly synonymized with Neurogenia Roman (Ctenopelmatinae: Perilissini) when Reshchikov et al. (2014) transferred the type (and only included) species, I. gorochovi Kasparyan, to Neurogenia. To resolve the taxonomic conflicts that remain within the subfamily Mesochorinae, seven new synonymies and two replacement names are proposed herein, together with a corrigendum for the identification key proposed by Araujo et al. (2018).
Impact of the Diurnal Radiation Contrast on the Contraction of Radius of Maximum Wind during Intensification of Hurricane Edouard (2014)
Authors: Tang Xiaodong , Tan Zhe-Min , Fang Juan , Munsell Erin B. , Zhang Fuqing 
Published: December 2018

Abstract
This work examines the impacts of the diurnal radiation contrast on the contraction rate of the radius of maximum wind (RMW) during intensification of Hurricane Edouard (2014) through convection-permitting simulations. Rapid contraction of RMW occurs both in the low and midlevels for the control run and the sensitivity run without solar insolation, while the tropical cyclone contracts more slowly in the low levels and later in the midlevels and thereafter fails to intensify continuously in the absence of the night phase, under weak vertical wind shear (~4 m s−1). The clouds at the top of the boundary layer absorb solar shortwave heating during the daytime, which enhanced the temperature inversion there and increased the convective inhibition, while nighttime destabilization and moistening in low levels through radiative cooling decrease convective inhibition and favor more convection inside the RMW than in the daytime phase. The budget analysis of the tangential wind tendency reveals that the greater positive radial vorticity flux inside of the RMW is the key RMW contraction mechanism in the boundary layer at night because of the enhanced convection. However, the greater positive vertical advection of tangential wind inside of the RMW dominates the RMW contraction in the midlevels.
Haematopoietic alterations in neonates with congenital diaphragmatic hernia receiving extracorporeal membrane oxygenation support
Authors: Dolscheid-Pommerich Ramona C , Kreuzer Alexander , Graeff Ingo , Stoffel-Wagner Birgit , Mueller Andreas , Kipfmueller Florian 
Published: December 2018

Background Extracorporeal membrane oxygenation procedure (ECMO) has been established in the therapy of respiratory insufficient infants with congenital diaphragmatic hernia. In congenital diaphragmatic hernia newborns, a delay in transfer to an ECMO centre is associated with a sharp increase in mortality. Predictive factors for ECMO support are urgently needed. We evaluated the routine parameters of the first blood withdrawal after birth in congenital diaphragmatic hernia infants, hypothesizing that early signs in bone marrow affecting haematology parameters for early regulation of potentially post birth hypoxia are predictive factors for ECMO support. Materials and methods In 44 patients born with congenital diaphragmatic hernia, differential blood cell count from the first blood withdrawal after birth was examined. Descriptive statistics included median, 95% confidence intervals, minimum and maximum differentiating ECMO/early mortality vs. no ECMO. Odds ratios with CI were calculated by binary logistic regression analysis. Best predictive markers were further checked in combination with the liver-up situation in two factorial regression models. Results In our cohort, the survival rate was 77.3% (34/44). While 18 neonates received ECMO support, 26 experienced no ECMO during hospital stay. Odds ratio calculations showed that risk for ECMO support increases with augmenting leukocytes, erythrocytes, haemoglobin, haematocrit, mean cell volume and absolute immature granulocytes. Further, the risk advanced in line with the severity of congenital diaphragmatic hernia assessed by prenatal ultrasound. Conclusions We conclude that these parameters are associated with disease severity in congenital diaphragmatic hernia newborns and may be considered potentially predictive biomarkers for the necessity of ECMO support.
The association of serum and vitreous adropin concentrations with diabetic retinopathy
Authors: Li Shipeng , Sun Jianling , Hu Wenchao , Liu Yan , Lin Dan , Duan Haiping , Liu Fengting 
Published: December 2018

Objective Adropin, a newly identified regulatory protein encoded by Enho gene, is correlated with insulin sensitivity and diabetes. The aim of this study is to determine whether serum and vitreous adropin concentrations are correlated with the presence of diabetic retinopathy. Methods A population of 165 patients with type 2 diabetes mellitus (52 without diabetic retinopathy, 69 with non-proliferative diabetic retinopathy and 44 patients with proliferative diabetic retinopathy) was enrolled in this study. The control group enrolled 68 healthy subjects who had underwent vitrectomy for retinal detachment. Serum and vitreous adropin concentrations were examined using enzyme-linked immunosorbent assay method. Results Control subjects had significantly higher serum and vitreous adropin concentrations compared with diabetic patients. Serum and vitreous adropin concentrations in proliferative diabetic retinopathy patients were significantly reduced compared with those in non-proliferative diabetic retinopathy patients and type 2 diabetes mellitus patients without diabetic retinopathy. In addition, there were lower serum and vitreous adropin concentrations in non-proliferative diabetic retinopathy patients compared with type 2 diabetes mellitus patients without diabetic retinopathy. Logistic regression analysis revealed that serum and vitreous adropin were associated with a decreased risk of type 2 diabetes mellitus and diabetic retinopathy. Conclusion Serum and vitreous adropin concentrations are negatively associated with the presence of diabetic retinopathy.