bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined Inhibition of PI3K, mTOR and Bcl-2 Significantly Radiosensitises Progesterone and Oestrogen Receptor Negative Breast Cancer Cells
Authors: Hamunyela Roswita , Hamid Mogammad , Serafin Antonio , Akudugu John 
Published: January 2019

Patients with triple-negative breast cancers (TNBC) constitute about one-fifth of all breast cancer patients. TNBC is an aggressive and heterogeneous disease entity in comparison with other types of breast cancer and, therefore, tends to be resistant to existing treatment regimens, such as, targeted and hormone therapies. There is evidence to suggest that proliferative and survival pathways of triple-negative tumours are still poorly understood, which could be the reason for the observed treatment resistance. Novel treatment approaches are, therefore, needed to overcome the challenges in the treatment of triple-negative breast cancers. Three human breast cell lines (MDAMB- 231, MCF-7 and MCF-12A) were pre-treated ith inhibitors of phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and the pro-survival gene (Bcl-2), and their radiosensitivities were evaluated using the clonogenic cell survival assay. Inhibition of PI3K, mTOR, and Bcl-2 with a cocktail of small molecule inhibitors NVP-BEZ235 and ABT-263 resulted in a 4- to 14-fold radiosensitisation of human breast cell lines with features similar to those of triple-negative cancers. These findings suggest that inhibition of I3K, mTOR, and Bcl-2 can significantly enhance the sensitivity of breast cells devoid of progesterone and oestrogen receptor expression. This approach may have therapeutic potential for breast cancer management.
A competência em informação aliada as tarefas do bibliotecário escolar
Authors: Ottonicar Selma Leticia Capinzaiki , Castro Filho Claudio Marcondes de , Sala Fabiana 
Published: January 2019

A Competência em informação é fundamental para que os indivíduos saibam acessar, avaliar e usar a informação de maneira eficaz ao longo da vida. Consiste em saber utilizar as tecnologias, buscar as informações em vários lugares, interpretar o texto, verificar a fonte de informação e produzir novos conhecimentos. O objetivo deste estudo é propor a aplicação dos princípios da Competência em informação ao elenco de tarefas dos bibliotecarios escolares. Os procedimentos metodológicos envolvem a pesquisa bibliográfica no âmbito da Competência em informação e das políticas públicas voltadas ao contexto das bibliotecas escolares. Para tanto, buscou-se em livros e artigos impressos e digitais em diferentes periódicos da área da ciência da informação. Como considerações finais, defende-se que a Competência em informação precisa ser considerada pelas políticas públicas da biblioteca escolar no Brasil, a fim de que se torne subsídio à prática do bibliotecário escolar e melhore o serviço oferecido pelas bibliotecas.
KAJIAN PENGEMBANGAN TEMPAT PELELANGAN IKAN (TPI) DI SENTRA KAWASAN PELABUHAN PERIKANAN MUARA KINTAP KABUPATEN TANAH LAUT PROVINSI KALIMANTAN SELATAN
Authors: Syarwani Akhmad , Mahyudin Idiannor , Mahreda Emmy Sri 
Published: January 2019

The potential Fish Auction Place in the fish port of Muara Kintap is expected to become the center of economic growth and development of fisheries. The existence of the facility is an input to the process of the function implementation in Fish Auction Place which condition is related to its availability and number in the fish port. The facilities which are managed optimally will produce the optimum output anyway. This study aimed to identify the presence of TPI in the central area of the Muara Kintap in Kecamatan Tanah Laut which has the potential to be developed. This study uses descriptive qualitative research and literature survey. Based on the survey results, it was revealed that the condition of Fish Auction Place (TPI) in the fish port of Muara Kintap in Kecamatan Tanah Laut did not implement a pure auction, it was due to the basic facilities, unwell maintained functional and supporting tools, and also due to the collaboration of some merchants in controlling prices. Several attempts to optimize Fish Auction Place (TPI) including the addition of supporting facilities, such as clean water, cool boxes, scales and carts/baskets as well as banks as partners in financial institutions to access capitals for a business group of fishermen. The comfortable condition of loading and unloading activities, as well as sanitation and hygiene, really needs to be fulfilled, including the revitalization of the fish fleet. Ideally, in every region of fishery activities in a fishermen concentration area, a fish port should be built, or at least fish hauling with clean Fish Auction Unit, to meet the requirements of the integrated quality program so that the selling prices of fish caught by fishermen con be rewarded appropriately. SWOT analysis results indicated that strategy chosen was the S - O (Strengths – Opportunities) which utilized all power of Muara Kintap Fish Port to take advantage of development opportunities as much as possible.
PROSPEK USAHA PENGOLAHAN UDANG REBON SKALA RUMAH TANGGA DI DESA MUARA KINTAP KECAMATAN KINTAP KABUPATEN TANAH LAUT PROVINSI KALIMANTAN SELATAN
Authors: Syahrin Alfi , Mahyudin Idiannor , Mahreda Emmy Sri 
Published: January 2019

The problems in rebon shrimp processing business at household scale in Desa Muara Kintap are in processing, utilization, and improvement in processing business which have not been maximized, and rebon shrimp quality of the business community at household scale because of inappropriate processing and handling, lack of interest, and cheap selling price. To overcome these problems, one possible way is to provide proper handling to the products of rebon shrimp either in producing or packaging as well as diversifying the processing of rebon shrimp. Therefore, this study aims to (1) determine benefits, eligibility, fluctuation and variation in price and (2) analyze marketing channels of rebon shrimp in Desa Muara Kintap. The significance of this research is that it can be used as an input or a reference in order to increase profits and development of business prospect of rebon shrimp processing at household scale in Desa Muara Kintap,Kecamatan Kintap,Kabupaten Tanah Laut, South Kalimantan Province; and it is also useful for those who want to learn more about the development of business prospect of rebon shrimp processing at household scale in Desa Muara Kintap,Kecamatan Kintap,Kabupaten Tanah Laut, or for those who are interested in the issues in this study. The results showed that the processing business of dried rebon shrimp in Muara Kintap was profitable to do because the total revenue was greater than the total cost, and based on the analysis of the eligibility on the season of NPV, Net BCR, and IRR were on top of the value of 13%, making it eligible to do business processing, and there was also a price fluctuation with an average selling price fluctuation of rebon shrimp in Desa Muara Kintap between ‘season’ and ‘not season' the prices was 41.05%, and the variation of the fishing season prices ranged from Rp 19,000 to Rp 20,000, while during ‘not season’ the prices were between Rp 26,000 and Rp 30,000. This happened because of the difference in total costs incurred by the fishermen and rebon shrimp processors and the difference in rebon shrimp production volume, and there were two marketing channels of rebon shrimps in Desa Muara Kintap.
PENDUGAAN POTENSI KEKERINGAN METEOROLOGIS TERHADAP KEBAKARAN HUTAN DAN LAHAN DENGAN METODE INDEKS PRESIPITASI TERSTANDARISASI DI KABUPATEN BANJAR
Authors: Supratono Dedy , Razie Fakhrur , Aryadi Mahrus , Badaruddin Badaruddin 
Published: January 2019

The potency of meteorological drought estimated by Standardized Precipitation Index can be used to predict the incidence of forest and land fires in Kabupaten Banjar. The aim of this research was to synthesize the relationship rainfall and level of dryness with the occurrence of hotspots, mapping meteorological drought in monthly periods and level of dryness of the method of Standardized Precipitation Index (SPI) and spreading of hotspots in Kabupaten Banjar. This research was conducted in Kabupaten Banjar by using the method of Standardized Precipitation Index to analyze the dryness level in one area. Data used were the processed monthly rainfalls in the period of 2010 – 2015 and the data of hotspots in Kabupaten Banjar, and then the maps for the hotspots and rainfall were created using mapping software. The results showed meteorological drought periods in Kabupaten Banjar happens nearly every year with the lowest period (very dry) occurred in November 2015 with a value of SPI -3.3. To conclude, first, the less rainfall and the low value of SPI will be followed by the increasing incidence of forest and land fires on the marks with the high number of hotspots, the second level of meteorological dryness occurs in January, July and up to November, and the last occurrence of high hotspots occurs in July up to November.
EKOLOGI TEMPAT TUMBUH SARANG SEMUT PADA TAMAN WISATA ALAM GUNUNG MEJA MANOKWARI
Authors: Sada Endria , Siburian Rima Herlina S. , Panambe Novita 
Published: January 2019

The ant-plant Sarang Semut is one of the medicinal antimicrobial plants that is very beneficial to human health. As such the plant has widely been exploited in their natural habitat. The silviculture of this plant is not available due to limited knowledge about the existence in nature. Therefore, it is imperative to undertake the ecological study on the growth site of this plant in nature to collect the basic information for the culture and cultivation of this plant. The method used in this research was the descriptive method with the survey technique in Gunung Meja Nature Tourism Park, Manokwari. The research showed that one species of ant-plant was found namely Myrmecodia cf. schlechteri Valeton. The plant is epifit to selective host plants such as Garcinia picrorrhiza, Sterculia macrophylla, Intsia bijuga, Pometia coreacea, and Antiaris toxicaria. The ideal growth zone of this plant is in Zone 2 and 3.
POTENSI SAYUR ORGANIK LOKAL DAERAH RAWA DI KALIMANTAN TENGAH: “MANFAAT DAN TINGKAT KESUKAAN”
Authors: Nion Yanetri Asi , Jemi Renhart , Jagau Yusurum , Anggreini Trisna , Anjalani Ria , Damanik Zafrullah , Torang Inga , Yuprin Yuprin 
Published: January 2019

Dayak tribe in Central Kalimantan Province has long time ago applied the local wisdom of healthy life and environmental friendly by consuming more local vegetables that grow wild. The research was conducted from July to September 2018, by conducting survey observations and interviewing respondents in Kapuas district, Pulang Pisau district, Katingan district, Gunung Mas district, and Palangka Raya city. There are a total of 14 species found from swamp areas, namely Singkah enyuh (Cocos nucifera), Singkah undus (Elaeis guineensis), Singkah hambie (Metroxylon sagu), singkah uwei (Calamus sp), Taya (Nauclea sp), Ujau (Bambusa sp), Bajei (Diplazium esculentum), Bakung (Crinum asiaticum), Kalakai (Stenochlaena palustris), Kujang (Colocasia esculenta), Uru mahamen (Neptunia olearecea), Pucuk teratai (Nymphae sp), Genjer (Limnocharis flava), dan Kangkung danum (Ipomoea aquatica). The benefits of local vegetables aside from being a food source that has the potential as a drug, pesticides, bioethanol and various other industrial materials. The majority of respondents aged over 40 years prefer vegetables (local) and food types were soup, while middle age (16-40 years) and young (under 16 years) can adapt to vegetables from outside and a new menu from outside Kalimantan. Factors for choosing the types of vegetables to be consumed are more influenced by taste reasons (54-86%), followed by habits (32-47%) and benefits for health (39-40%).
PENGGUNAAN ASAP CAIR TANDAN KOSONG KELAPA SAWIT (TKKS) SEBAGAI PESTISIDA NABATI UNTUK MENGENDALIKAN HAMA PERUSAK DAUN TANAMAN SAWI (Brassica juncea L.)
Authors: Sari Yulia P. , Samharinto Samharnto , Langai Bambang F. 
Published: January 2019

The aims of this research are to identify the dominant type of pest that attack mustard plants, to identify the component of liquid smoke of oil palm empty fruit bunches, to examine the effects of interaction between concentration level and frequency of application of liquid smoke spraying to the intensity of leaf damaging pests attack on mustard plants, to examine the effects of some concentration level and frequency of application of liquid smoke spraying severally to the intensity of leaf damaging pests attack on mustard plants, and to determine effective concentration and frequency of application of liquid smoke spraying to decrease the intensity of leaf damaging pests attack mustard plants. The research results showed that leaf damaging pests found have attacked mustard plants during the research period are Plutella xylostella L., Spodoptera litura, long caterpillar (Plusia spp.), and Crocidolomia binotalis. The test result for chemical content showed that liquid smoke of oil palm empty fruit bunches contained 20 types of chemical compounds. The compounds with the most content found are Ethylene glycol, Acetic Acid, Phenol/Benzenol & Benzene sulfonic acid/Carbamic acid, Acetone, and Butyrolactone with each successive concentration, i.e. 52,06 %, 22,67 %, 7,76 %, 4,67 %, and 2,77 %, where it is known that phenol and acetic acid are compounds that can play a role as insecticides for pests. The effect of treatments (liquid smoke concentration, spraying frequency, and their interaction) is very real different compared to without treatment spraying liquid smoke solution (control), while the effect of concentrations (2,5ml/l;5ml/l;7,5ml/l;10ml/l) of liquid smoke and spraying frequency (once, twice, and three times a week) and their interaction severally has no real effect, giving treatments (concentration and spraying frequency of liquid smoke) decrease the intensity of pests attack for 24,83%, increase the number of leaves for 8,36%, fresh weight of plants for 127,39%, and shoot-root ratio (SRR) for 44,62%.
Dampak Penggunaan Alat Mesin Panen terhadap Kelembagaan Usaha Tani Padi
Authors: Purwantini Tri Bastuti , Susilowati Sri Hery 
Published: January 2019

<p><span>Mechanization is a solution for agricultural workforce scarcity, especially in rice farming. This paper aims to study performances and impacts of harvesting and threshing machines on labor institution of rice farming. This research employed survey data of National Farmer’s Panel study conducted by ICASEPS in 2010 and 2015 in wetland agro-ecosystems in Sidrap, Karawang, and Subang Regencies. Data were analyzed descriptively. Mechanization technologies were more efficient in terms of number and time of labor use compared to that of traditional. Negative impact of the machines was share croppers elimination because the land owner tended to cultivate their own farm land. Some labor lose their job opportunity, some got less income from local income share system. Farmers were unprepared to manage agricultural machinery. It is necessary to provide alternative employment for the affected workers. Agricultural mechanization needs to deal with existing traditional labor institutions to having mutual benefit.</span></p><p> </p><p>Abstrak</p><p>Mekanisasi merupakan solusi dari semakin langkanya keberadaan tenaga kerja pertanian, terutama dalam usaha tani padi. Konsekuensi dari adopsi teknologi berdampak pada kinerja ketenagakerjaan dan kelembagaan pertanian setempat. Tulisan ini bertujuan untuk mengkaji faktor-faktor yang mempengaruhi arah perubahan penggunaan alat mesin panen dan perontokan padi serta dampaknya terhadap kelembagaan usaha pertanian padi sawah. Data yang digunakan adalah data base Panel Petani Nasional yang dilakukan oleh PSEKP tahun 2010, 2015 dan 2016. Kajian ini mengambil kasus pada lokasi penelitian agroekosistem lahan sawah di Desa Simpar (Subang). Sindangsari (Karawang) dan Desa Carawali (Kabupaten Sidrap), Analisis data dilakukan secara deskriptif. Hasil kajian menyimpulkan bahwa adopsi teknologi mekanisasi dalam kegiatan panen lebih efisien baik dari sisi tenaga kerja, biaya maupun waktu. Selain itu juga mengurangi kehilangan hasil. Dampak negatifnya menggeser pola kelembagaan penggarapan lahan dari pola sakap menyakap ke arah menggarap lahannya sendiri. Sebagian buruh tani kehilangan kesempatan kerja, berkurangnya bagian (upah) buruh tani dalam sistem bawon yang berlaku setempat. Beberapa masalah lain yang timbul adalah kurangnya kesiapan petani dalam pengelolaan alsintan. Untuk mengatasi dampak negatif berkurangnya kesempatan kerja bagi pembawon serta penyakap, maka diperlukan fasilitasi untuk tumbuhnya alternatif kesempatan kerja bagi buruh yang terdampak oleh penggunaan alsintan tersebut. Selain itu, perubahan usahatani ke arah mekanisasi pertanian tersebut juga harus mempertimbangkan tatanan kelembagaan dan ketenagakerjaan setempat agar dapat tetap berjalan dengan saling menguntungkan.</p>
Sedative use of Dexmedetomidine vs. Propofol after Cardiac Surgery: A critical review and meta-analysis.
Authors: Abowali Hesham , Paganini Matteo , Elbadawi Ayman , Camporesi Enrico 
Published: January 2019

Abstract
BACKGROUND: The efficacy and safety of dexmedetomidine in sedation for postoperative cardiac surgeries is controversial when compared to propofol.
METHODS: A computerized search of Medline, Cochrane and Google Scholar databases was performed through August 2018. Studies evaluating the efficacy of dexmedetomidine versus propofol in the sedation of postoperative cardiac surgery patients were searched. The main study outcomes were divided into time dependent (mechanical ventilation time; time to extubation; length of stay in the intensive care unit and in the hospital) and non-time dependent (delirium, bradycardia, and hypotension).
RESULTS: The final analysis included 15 trials with a total of 2488 patients. Time to extubation was significantly reduced in the dexmedetomidine group (Standardized Mean Difference (SMD) = -0.54, 95% Confidence Interval (CI): -0.89 to -0.18, p=0.003), as well as mechanical ventilation time (SMD= -0.71, 95% CI: -1.19 to -0.23, p=0.004). Moreover, the dexmedetomidine group showed a significant reduction in Intensive Care Unit length of stay (SMD= -0.38, 95% CI: -0.60 to -0.16, p=0.001) and hospital length of stay (SMD= -0.39, 95% CI: -0.60 to -0.19, p<0.001). However, these time dependent outcomes could have been affected by several confounding factors, thus limiting the value of these results. Incidence of delirium was reduced in the dexmedetomidine group (OR: 0.47, 95% CI: 0.29 to 0.76, p=0.002), while this group of patients had higher rates of bradycardia (OR: 2.52, 95% CI: 1.15 to 5.55, p=0.021). There was no significant difference in rates of hypotension between the two groups.
CONCLUSION: Despite the apparent time advantages afforded by dexmedetomidine over propofol, the former does not show particular overall improvements in postoperative care of cardiac surgery patients. Since time dependent outcomes seems to be affected by several confounding factors, more efforts are needed to analyze factors that could affect sedation in post-cardiac surgery patients and choose unbiased outcomes.
KEYWORDS: Dexmedetomidine; propofol; cardiac surgery; postoperative sedation.
3D Printing Technology in Design of Pharmaceutical Products
Authors: Ameeduzzafar  , Alruwaili Nabil K. , Rizwanullah Md. , Abbas Bukhari Syed Nasir , Amir Mohd , Ahmed Muhammad Masood , Fazil Mohammad 
Published: January 2019

Background:
Three-dimensional printing (3DP) is a novel technology for fabrication of personalized
medicine. As of late, FDA affirmed 3D printed tranquilize item in August 2015, which is characteristic of another
section of Pharmaceutical assembling. 3DP incorporates a wide range of assembling procedures, which are altogether
founded on computer-aided design (CAD), and controlled deposition of materials (layer-by-layer) to make
freestyle geometries. Conventionally, many pharmaceutical processes like compressed tablet have been used from
many years for the development of tablet with established regulatory pathways. But this simple process is outdated
in terms of process competence and manufacturing flexibility (design space). 3DP is a new technology for the creation
of plan, proving to be superior for complex products, customized items and items made on-request. It creates
new opportunities for improving efficacy, safety, and convenience of medicines.

Method:
There are many of the 3D printing technology used for the development of personalized medicine on demand
for better treatment like 3D powder direct printing technology, fused-filament 3D printing, 3D extrusion
printer, piezoelectric inkjet printer, fused deposition 3D printing, 3D printer, ink-jet printer, micro-drop inkjet 3DP,
thermal inkjet printer, multi-nozzle 3D printer, stereolithographic 3D printer.

Result:

This review highlights features how item and process comprehension can encourage the improvement of a
control technique for various 3D printing strategies.

Conclusion:
It is concluded that the 3D printing technology is a novel potential for manufacturing of personalized
dose medicines, due to better patient compliance which can be prepared when needed.
Effects of Nutrients and Exercises to Attenuate Oxidative Stress and Prevent Cardiovascular Disease
Authors: Neves Mario F. , Cunha Michelle R. , de Paula Tainah 
Published: January 2019

Background:
In recent years, it has become more evident that oxidative stress is involved in the development
of cardiovascular disease. Indeed, reactive oxygen species seems to be the common mechanism for endothelial
dysfunction, vascular inflammation and arterial stiffness, resulting in a blood pressure increase and early
vascular aging.

Methods:
This review presents the potential role of antioxidant nutrients and exercise for cardiovascular protection.

Results:
Flavonoids, vitamins and minerals present in some fruits and foliage are considered natural antioxidants.
In fact, fruits and vegetables contain large amounts of antioxidants. Several clinical trials have extensively studied
vitamin E, beta-carotene, vitamin C, polyphenols, plus selenium and zinc. In addition, many authors have been
carried out clinical trials to evaluate the mechanisms of oxidative stress attenuation after exercise. Exercise responses
may vary according to the Frequency, Intensity, Time and Type (FITT) principle, making it difficult to
obtain a consensus concerning the exercise properties and redox status. High-intensity interval training (HIIT) has
been reported as an efficient option for metabolic adaptations in a short time. Aerobic exercises must be performed
at least three times a week, for two months or more, using moderate to vigorous intensity to promote a
positive effect on oxidative stress and vascular function.

Conclusion:
The recognition of appropriate nutrients and exercise with antioxidant properties may be an important
supportive approach to impair early vascular aging and to prevent cardiovascular disease.