bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laboratory validation of a clinical metagenomic next-generation sequencing assay for respiratory virus detection and discovery
Authors: Tan Jessica Karielle , Servellita Venice , Stryke Doug , Kelly Emily , Streithorst Jessica , Sumimoto Nanami , Foresythe Abiodun , Huh Hee Jae , Nguyen Jenny , Oseguera Miriam , Brazer Noah , Tang Jack , Ingebrigtsen Danielle , Fung Becky , Reyes Helen , Hillberg Melissa , Chen Alice , Guevara Hugo , Yagi Shigeo , Morales Christina , Wadford Debra A. , Mourani Peter M. , Langelier Charles R. , de Lorenzi-Tognon Mikael , Benoit Patrick , Chiu Charles Y. 
Published: November 2024

AbstractTools for rapid identification of novel and/or emerging viruses are urgently needed for clinical diagnosis of unexplained infections and pandemic preparedness. Here we developed and clinically validated a largely automated metagenomic next-generation sequencing (mNGS) assay for agnostic detection of respiratory viral pathogens from upper respiratory swab and bronchoalveolar lavage samples in <24 h. The mNGS assay achieved mean limits of detection of 543 copies/mL, viral load quantification with 100% linearity, and 93.6% sensitivity, 93.8% specificity, and 93.7% accuracy compared to gold-standard clinical multiplex RT-PCR testing. Performance increased to 97.9% overall predictive agreement after discrepancy testing and clinical adjudication, which was superior to that of RT-PCR (95.0% agreement). To enable discovery of novel, sequence-divergent human viruses with pandemic potential, de novo assembly and translated nucleotide algorithms were incorporated into the automated SURPI+ computational pipeline used by the mNGS assay for pathogen detection. Using in silico analysis, we showed that after removal of all human viral sequences from the reference database, 70 (100%) of 70 representative human viral pathogens could still be identified based on homology to related animal or plant viruses. Our assay, which was granted breakthrough device designation from the US Food and Drug Administration (FDA) in August of 2023, demonstrates the feasibility of routine mNGS testing in clinical and public health laboratories, thus facilitating a robust and rapid response to the next viral pandemic.
Robustness of quantum chaos and anomalous relaxation in open quantum circuits
Authors: Yoshimura Takato , Sá Lucas 
Published: November 2024

AbstractDissipation is a ubiquitous phenomenon that affects the fate of chaotic quantum many-body dynamics. Here, we show that chaos can be robust against dissipation but can also assist and anomalously enhance relaxation. We compute exactly the dissipative form factor of a generic Floquet quantum circuit with arbitrary on-site dissipation modeled by quantum channels and find that, for long enough times, the system always relaxes with two distinctive regimes characterized by the presence or absence of gap-closing. While the system can sustain a robust ramp for a long (but finite) time interval in the gap-closing regime, relaxation is “assisted” by quantum chaos in the regime where the gap remains nonzero. In the latter regime, we prove that, if the thermodynamic limit is taken first, the gap does not close even in the dissipationless limit. We complement our analytical findings with numerical results for quantum qubit circuits.
Hermetic hydrovoltaic cell sustained by internal water circulation
Authors: Yuan Renxuan , Li Huizeng , Zhao Zhipeng , Li An , Xue Luanluan , Li Kaixuan , Deng Xiao , Yu Xinye , Li Rujun , Liu Quan , Song Yanlin 
Published: November 2024

AbstractNumerous efforts have been devoted to harvesting sustainable energy from environment. Among the promising renewable resources, ambient heat exhibits attractive prospects due to its ubiquity and inexhaustibility, and has been converted into electricity through water evaporation-induced hydrovoltaic approaches. However, current hydrovoltaic approaches function only in low-humidity environments and continuously consume water. Herein, we fabricate a hermetic hydrovoltaic cell (HHC) to harvest ambient heat, and have fully addressed the limitations posed by environmental conditions. Meanwhile, for the first time we develop an internal circulation hydrovoltaic mechanism. Taking advantage of the heterogeneous wicking bilayer structure, we verify that inside the hermetic cell, the ambient temperature fluctuation-induced evaporation and further the water circulation can persist, which sustains the hydrovoltaic effect to convert ambient heat into electricity. More importantly, the hermetic design enables the cell to work continuously and reliably for 160 h with negligible water consumption, unaffected by external influences such as wind and light, making it an excellent candidate for extreme situations such as water-scarce deserts, highly humid tropical rain forests, rainy days, and dark underground engineering. These findings provide an easily accessible and widely applicable route for stably harnessing renewable energy, and more notably, offer a novel paradigm toward leveraging low-grade ambient heat energy via circulation design.
A technocognitive approach to detecting fallacies in climate misinformation
Authors: Zanartu Francisco , Cook John , Wagner Markus , García Julian 
Published: November 2024

AbstractMisinformation about climate change is a complex societal issue that requires holistic, interdisciplinary solutions at the intersection between technology and psychology. One proposed solution is a “technocognitive” approach, involving the synthesis of psychological and computer science research. Psychological research has identified that interventions that counter misinformation require both fact-based (e.g., factual explanations) and technique-based (e.g., explanations of misleading techniques and logical fallacies) content. However, little progress has been made on documenting and detecting fallacies in climate misinformation. In this study, we apply a previously developed critical thinking methodology for deconstructing climate misinformation in order to develop a dataset mapping examples of climate misinformation to reasoning fallacies. This dataset is used to train a model to detect fallacies in climate misinformation. We evaluate the model’s performance using the $$\text {F}_\text {1}$$

F
1

score, which measures how well the model detects relevant cases while avoiding irrelevant ones. Our study shows $$\text {F}_\text {1}$$

F
1

scores that are 2.5–3.5 times better than previous works. The fallacies that are easiest to detect include fake experts and anecdotal arguments, while fallacies that require background knowledge, such as oversimplification, misrepresentation, and slothful induction, are relatively more difficult to detect. This research lays the groundwork for development of solutions where automatically detected climate misinformation can be countered with generative technique-based corrections.
Sex-dependent effects of early life sensory overstimulation on later life behavioral function in rats
Authors: Porras Abishag , Rodney-Hernández Paolaenid , Jackson Jeffy , Nguyen Christine H. , Rincón-Cortés Millie 
Published: November 2024

AbstractChildren today are immersed in electronic technology shortly after birth as they now begin regularly watching television earlier than they did in the past. Many new programs geared towards infants contain lots of lights, color, and sounds, which may constitute a form of sensory overstimulation (SOS) that leads to cognitive and behavioral changes in children and adolescents. Here, we examined the impact of early life SOS exposure on later life behavioral and cognitive function in rodents by exposing developing male and female rats to excessive audiovisual stimulation from postnatal days (PND) 10–40 and assessing anxiety-like behavior, social motivation, compulsive behavior, and spatial learning/cognition from PND 50–60. To evaluate potential SOS effects on hypothalamic–pituitary–adrenal (HPA)-axis function, levels of the stress hormone corticosterone (CORT) were measured at 3 timepoints (e.g., PND 23, 41, 61) post-SOS exposure. Sensory overstimulated males exhibited reduced anxiety-like and compulsive behavior compared to controls, whereas females exhibited reduced social motivation but enhanced spatial learning/cognition compared to controls. No differences in baseline CORT levels were found at any age tested, suggesting no impact of early life SOS on later life basal HPA-axis function. Our results demonstrate sex-specific effects of early life SOS on distinct behavioral domains in early adult rats.
The influence of body posture on facial expression perception in Autism
Authors: Finn Abigail , Shah Punit , de la Rosa Stephan , Teufel Christoph , von dem Hagen Elisabeth 
Published: November 2024

AbstractFacial expression perception is influenced by body posture, with perception biased toward the body emotion. Previous research has suggested that the magnitude of this biasing influence of body posture is driven by individual differences in the precision of facial expression representations underlying discrimination abilities, where lower precision leads to a greater influence of body posture. It is unclear however whether similar mechanisms might drive the influence of contextual cues in Autism, which is often characterised by reduced facial expression discrimination abilities. Here, we addressed this question by using online psychophysical methods to determine the precision of isolated face and body expression representations of anger and disgust, and the influence of body on facial expression perception, in autistic and non-autistic adults. Both groups showed a strong influence of body context on facial expression perception, but this influence was larger in the autistic group, mirroring their lower overall precision of facial expression representations relative to non-autistic individuals. Crucially, the magnitude of the biasing influence of body posture in both groups was related to the precision of individuals’ facial expression representations. The results suggest that similar principles govern the integration of facial expression and body posture information in both autistic and non-autistic individuals.
Reanalysis of graphite nuclear data limits for AGR dosimetry with updated carbon scattering data and Magnox plant measurements
Authors: Shaw S.E. , Allen D.A. 
Published: November 2024

The Advanced Gas-cooled Reactors (AGR) operating in the UK are, like the Magnox reactors that preceded them, graphite moderated and cooled by pressurised CO2 gas. As such, the nuclear data for carbon are of primary importance in neutron dosimetry and nuclear heating calculations.
There is evidence from benchmark data and plant measurements of underprediction of neutron fluxes at the lower end of the fast neutron range for thicknesses of graphite greater than ~50 cm. Furthermore, the range of validation is limited to ~70 cm of graphite, with components beyond this being allocated bounding damage rates.
Following the previous ISRD, opportunities were taken to:

Look again at the carbon scattering cross-sections by incorporating the ENDF/B-VIII.0 Beta 4 carbon data to assess the impact on the analysis of benchmark data.
Reassess validation data from the earlier Magnox reactors to put them on a more appropriate equivalent graphite thickness scale to the AGRs.

The investigation into graphite nuclear data libraries concluded that the incorporation of ENDF/B-VIII Beta 4 carbon data into the JEF2.2 and ENDF/B-VII.1 data libraries with BINGO collision processing had only a limited effect on the calculated responses. The UKNDL data, with DICE collision processing, currently used in dosimetry calculations for EDF Energy’s AGRs produces the closest agreement with measurement for all calculated responses for graphite thicknesses greater than 10 cm.
For reactor plant validation, applying the sensitivity of the 93mNb(n,n’) response to graphite density resulted in a 15 cm increase to the validation database when compared to a simple “straight-line” distance. However, caution is advised in applying the benchmark equivalent distance derived from locations within a graphite column, to ex-core plant measurements.
Perceptions, experiences and concerns with sexually transmitted infections among current and former PrEP users: a longitudinal qualitative study of gay, bisexual and queer men in Canada
Authors: Daroya Emerich , Wells Alex , Gaspar Mark , Sinno Jad , Hull Mark , Lachowsky Nathan J. , Tan Darrell H. S. , Grace Daniel 
Published: November 2024

Background Pre-exposure prophylaxis (PrEP) use has been attributed to heightened rates of sexually transmitted infections (STIs), ostensibly due to increased condomless anal sex (CAS) and greater frequency of STI testing. Few qualitative studies have assessed how gay, bisexual and queer men (GBQM) who use PrEP perceive STIs and how these attitudes have evolved post-PrEP uptake. We investigated the perspectives of current and former PrEP users on STIs. Methods Annual, in-depth longitudinal interviews were conducted with 38 current and former PrEP users in Ontario (n = 18) and British Columbia (n = 20), Canada, as part of a mixed-methods implementation science study (2020–2022). Over 3 years, 109 interviews were conducted. Data analysis included reflexive thematic coding and longitudinal recurrent cross-sectional analysis using NVivo 12. Results Four STI-related themes emerged: (1) lack of STI-related concerns due to treatment and prevention optimism, (2) stigma-related concerns, (3) perceived risk among other PrEP users due to increased CAS, and (4) inconsistent testing concerns among non-PrEP users. Over time, some STI-related anxieties decreased with increased knowledge and reduced stigma. However, concerns persisted for other participants due to perceived risky sexual behaviours among other PrEP users and non-PrEP users. Both current and former PrEP users who expressed STI-related apprehensions consistently indicated adopting risk-reduction strategies, including condom use and having fewer sexual partners throughout the study. Conclusions Findings show how varied STI perceptions and experiences among current and former PrEP users shaped sexual decision-making over time. Providers, public health experts, and policymakers should develop a more comprehensive strategy to address STI concerns among GBQM.
Technology and Research on Improving Oil Recovery by Volume Fracturing with Phase Change Permeability in Ultra-low Permeability Reservoirs
Authors: Wang Ce , Zhu Xi-Zhu , Jiang Tian-Hao , Yi Fan 
Published: November 2024

Abstract
The conventional water injection development production wells in ultra-low permeability reservoirs have low efficiency, low production and low liquid content, and poor economic benefits. Traditional water drive development techniques are difficult to adapt to the requirements of economically effective development in ultra-low permeability reservoirs. Therefore, it is urgent to adjust development ideas and transform water injection development methods. A major development experiment was carried out in the Y284 area of Huaqing Oilfield to transform the water injection development method. Based on the mechanism of reverse osmosis flooding in oil recovery wells, this article uses dynamic monitoring technologies such as downhole microseismic to achieve three-dimensional reservoir transformation, and establishes a large-scale fracturing technology of “collaborative permeability flooding, volume fracturing, and multi-stage temporary plugging” for reverse osmosis wells in ultra-low permeability reservoirs. Research has shown that large-scale fracturing technology for water injection wells can improve single well oil recovery speed by increasing the complexity of fracture networks. The important factors affecting the effectiveness of water injection wells include reservoir properties, fracturing transformation scale, cumulative water injection volume, remaining oil distribution, and heterogeneity of aquifers. At the same time, the construction parameters of large-scale volume fracturing for water injection wells, namely 140-170m, are quantitatively determined based on the actual situation of the mining field &sup3; The amount of sand added, a sand ratio of 17-22%, and a large displacement of 8-10m3/min, 1400-2000m &sup3; The amount of liquid entering the ground can most effectively achieve the conditions for reservoir transformation. The conclusion is that large-scale fracturing technology for conversion wells provides technical support for volume fracturing and optimization design of fracturing parameters for low production wells in ultra-low permeability reservoirs, and can provide guidance and reference for the efficient development of other similar ultra-low permeability reservoirs.
Research on Wellbore Blockage Mechanism and Blockage Removal Technology of Shale Gas Wells
Authors: Yuan Yaoshun , Du Juan , Liu Pingli , Zou Qi , Chen Xiang , Liu Jinming 
Published: November 2024

Abstract
With the continuous extension of development time, the production decline of single well is accelerated, and the problem of wellbore blockage in shale gas wells is prominent. The problem of wellbore blockage seriously restricts the stable production and efficient development of gas fields. In this paper, the ‘micro + macro’ analysis method is used to study the blockage. It is found that the wellbore blockage mainly includes corrosion, scaling products and a small amount of clay minerals brought by the reservoir during gas production. In the process of production, corrosion and scaling mechanism work together. Acidic gas such as CO2 in shale gas are dissolved in high-salinity formation water, causing electrochemical corrosion of the string. The formation of corrosion products will promote the deposition and adsorption of inorganic scales. The uneven accumulation of corrosion product films will enhance the surface roughness of the substrate and accelerate the deposition of scale samples around the crystal nucleus. At the same time, scaling will cause corrosion under the scale of the pipe string. Cl− can penetrate into the film through the micropores covering the product film on the metal surface, and pitting corrosion occurs to corrode the pipe string. Finally, the corrosion and scaling products together cause the pipe string to be blocked. Based on the analysis results of blockages and water samples, a blockage removal liquid system was developed according to the blockage mechanism. It has a high dissolution ability and the corrosion of 125SG, 155V and N80 steel sheets at 60°C for 4h is less than 1 g/(m2·h), which meets the requirements of industry standards. This system can inhibit the secondary precipitation of metal ions, has low corrosion damage to oil and casing, can remove wellbore blockage, does not need to flow back, will not cause secondary damage to the reservoir. It can provide guiding significance for similar shale gas well wellbore blockage removal.
Medieval physics at Oxford: who, what and why?
Authors: Hannam James 
Published: November 2024

Abstract
The University of Oxford was an important centre for natural philosophy including physics in particular during the Middle Ages. Among several important figures, the so-called Merton Calculators hold pride of place for their work integrating mathematics into physics. Their advances were influential across western Europe and formed part of Galileo Galilei’s new science of kinematics in the seventeenth century. The surviving syllabi show that Oxford students were expected to cover Aristotle’s natural philosophy in some detail, as well as the four branches of mathematics: arithmetic, music, geometry and astronomy.
Dynamic optimization design of thin plate structure based on surrogate model
Authors: Ma Weijie , Nie Kun , Wang Shaowei 
Published: November 2024

Abstract
To enhance dynamic optimization efficiency in traditional thin plate structures, surrogate models are integrated for structural dynamic size optimization, reducing dependence on high-precision finite element simulations. This paper focuses on optimizing the aluminum alloy sheet as the subject of research. The parameters of the specimen are optimized through sensitivity analysis, based on the comparison between the free mode Finite Element Analysis (FEA) and Experimental Modal Analysis (EMA) results. The modified specimen undergoes validation under a four-edge clamped boundary condition. Subsequently, random vibration analysis is conducted to determine the root mean square (RMS) value of the acceleration response. Employing surrogate model technology, four models are constructed using parametric modeling and experimental design methods. These models are then compared for their fitting effectiveness. The results indicate that the RBF model exhibits the highest accuracy in fitting each response, effectively replacing dynamic simulation. Finally, the RBF combined with the NSGA-II method, optimizes the specimen’s structural size, resulting in a 21.6% reduction in mass and an 18.60% decrease in acceleration response. These outcomes demonstrate satisfactory optimization results, ensuring accuracy while enhancing the dynamic characteristics of the specimen structure. This research offers valuable insights for related engineering applications.
Research on the trajectory tracking method of aircraft towing systems based on nonlinear control
Authors: Cui Yuxin , Yao Zhining , Zhang Hongyan , Ni Tao , Wang Chaofei 
Published: November 2024

Abstract
In this paper, for the towing problem of wheeled aircraft, an automatic control method is proposed based on the nonlinear control theory, which realizes the trajectory tracking of the aircraft by controlling the velocity of the towing point of the aircraft, so as to realize the aircraft’s outbound and inbound operations. Firstly, based on the nonholonomic constraint theory, the mathematical model of the aircraft towing system is established, and the kinematic relationship between the aircraft towing point and the aircraft is obtained. Then, a controller is designed based on the nonlinear control theory, and the stability analysis is carried out using the Lyapunov method to realize the trajectory tracking of the aircraft traction system. Finally, the effectiveness and accuracy of the control method are verified by the combination of MATLAB simulation analysis and scaled-down model experiment. The results show that the proposed control method can realize the trajectory control of the aircraft towing system.
The Fate of Creative Ideas
Authors: Honneth Axel 
Published: November 2024

Abstract
This paper explores Max Weber’s reasons for claiming that morally exemplary ideas with some regularity produce the unwanted result of highly dubious ethical consequences. The diagnosis of such “normative paradoxes” is Weber’s attempt to refute the optimistic philosophies of history with their own tools. If the philosophy of the Enlightenment assumed that bold, progressive ideas could steer the world toward improvement, Weber sought to demonstrate that the opposite was true: once such ideas became historically effective, there was a certain inevitability with which they produced evil and social harm. It will be shown that Weber thought he could justify this thesis by demonstrating that it is ultimately the givens of human nature that stand in the way of any linear and faithful realization of morally well-intentioned ideas, and even cause them to be transformed into their opposites.