bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anatomical Variations of the Middle Turbinate Concha Bullosa and its Relationship with Chronic Sinusitis: A Prospective Radiologic Study
Authors: Kalaiarasi Raja , Ramakrishnan Venkataramanan , Poyyamoli Santhosh 
Published: March 2018

Introduction A pneumatized turbinate, also called concha bullosa, is a normal anatomical variant of the paranasal sinus region. Depending on the site of pneumatization, the concha is classified into extensive, bulbous or lamellar type. The middle turbinate concha bullosa has been implicated as a possible etiological factor in chronic sinusitis.
Objectives The aim of this study was to investigate the anatomical variations of the concha bullosa, based on paranasal sinus imaging, and its possible association with sinusitis.
Methods This prospective descriptive study was performed at the Department of ENT and Head Neck Surgery over a period of one year, from 2016 to 2017. We studied the computed tomography scans of the nose and paranasal sinuses— in axial, coronal and sagittal planes—of patients who had symptoms of nasal obstruction, or headache and features of chronic sinusitis.
Results Out of the 202 scans studied, the prevalence of concha bullosa was 31.7%. The concha was bilateral in 35 (54.7%) patients and unilateral in 29 (45.3%) patients. Out of 99 conchae, 54 were on the right side and 45 were on left side. Ipsilateral sinusitis was found in 40.4% of the sides in the scans of subjects with concha. There was no statistically significant association between any type of middle turbinate concha with sinusitis, but sinusitis was more predominant with the extensive type of concha (p > 0.05).
Conclusion Multiple air cells, mucocele, pyocele and inflammatory mucosal thickenings in the concha are relatively rare. Detailed knowledge of anatomic variations of the concha bullosa is imperative for the radiologists and the operating surgeons.
Management of Diabetes in the Intrapartum and Postpartum Patient
Authors: Niznik Charlotte , Szmuilowicz Emily , Peaceman Alan , Yee Lynn , Dude Annie 
Published: March 2018

AbstractAchieving maternal euglycemia in women with pregestational and gestational diabetes mellitus is critical to decreasing the risk of neonatal hypoglycemia, as maternal blood glucose levels around the time of delivery are directly related to the risk of hypoglycemia in the neonate. Many institutions use continuous insulin and glucose infusions during the intrapartum period, although practices are widely variable. At Northwestern Memorial Hospital, the “Management of the Perinatal Patient with Diabetes” policy and protocol was developed to improve consistency of management while also allowing individualization appropriate for the patient's specific diabetic needs. This protocol introduced standardized algorithms based on maternal insulin requirements to drive real-time maternal glucose control during labor as well as provided guidelines for postpartum glycemic control. This manuscript describes the development and implementation of this protocol to encourage other institutions to adopt a standardized protocol that allows highly individualized intrapartum care to women with diabetes.
Perioperative Complications of Esophageal Atresia
Authors: Conforti Andrea , Bagolan Pietro , Morini Francesco 
Published: March 2018

AbstractCurrent survival rate of infants with esophageal atresia with/without tracheoesophageal fistula (EA/TEF) exceeds 90% and great interest is dedicated to the long-term outcomes and complications. However, perioperative complications represent a significant burden to the EA/TEF infants and a technical challenge for the surgeon. In this review, we will focus on the most frequent perioperative complications specific of EA/TEF to describe their predisposing factors, possible preventive measures, and treatment options.
Perioperative Complications Following Surgery for Necrotizing Enterocolitis
Authors: Mutanen Annika , Pierro Agostino , Zani Augusto 
Published: March 2018

AbstractNecrotizing enterocolitis (NEC) is a devastating condition that mainly affects premature infants. Advanced cases of NEC require surgical treatment, which in up to 70% of infants is associated with significant perioperative morbidity including anastomosis- or enterostomy-related complications, sepsis, peritonitis, and wound infections. Moreover, the perioperative complications may compromise the long-term gastrointestinal and neurodevelopmental outcome of patients requiring surgery for NEC.
Two Genetic Variants Associated with Plantar Fascial Disorders
Authors: Kim Stuart , Ioannidis John , Ahmed Marwa , Avins Andrew , Kleimeyer John , Fredericson Michael , Dragoo Jason 
Published: March 2018

AbstractPlantar fascial disorder is comprised of plantar fasciitis and plantar fibromatosis. Plantar fasciitis is the most common cause of heel pain, especially for athletes involved in running and jumping sports. Plantar fibromatosis is a rare fibrous hyperproliferation of the deep connective tissue of the foot. To identify genetic loci associated with plantar fascial disorders, a genome-wide association screen was performed using publically available data from the Research Program in Genes, Environment and Health including 21,624 cases of plantar fascial disorders and 80,879 controls. One indel (chr5:118704153:D) and one SNP (rs62051384) showed an association with plantar fascial disorders at genome-wide significance (p<5×10−8) with small effects (odds ratios=0.93 and 1.07 per allele, respectively). The indel chr5:118704153:D is located within TNFAIP8 (encodes a protein induced by TNF alpha) and rs62051384 is located within WWP2 (which is involved in proteasomal degradation). These DNA variants may be informative in explaining why some individuals are at higher risk for plantar fascial disorders than others.
Interdisziplinäre Versorgung
Authors: Augurzky Boris , Emde Annika 
Published: March 2018

ZusammenfassungHerausforderungen in der Nephrologie wie die Ambulantisierung, Kommerzialisierung der ambulanten
Dialysebehandlungen und eine Auflösung der stationären Abteilungen im generellen Leistungsspektrum führen
dazu, dass die Nephrologie langfristig an Bedeutung verlieren und Nachwuchsproblemen entgegenlaufen kann. Zur
Sicherstellung der nephrologischen Hauptabteilungen im Krankenhaus werden in der hier vorgestellten
Untersuchung medizinische und wirtschaftliche Erfolgsfaktoren identifiziert. Insgesamt wurden dazu rund 240
000 Patientendaten aus 6 Krankenhäusern mit einer Hauptfachabteilung Nephrologie ausgewertet und 4
Experteninterwies durchgeführt. Im Ergebnis können 16 Erfolgsfaktoren identifiziert werden, darunter eine
ausreichende Abteilungsgröße, eine genügend gute Abgrenzung im medizinischen Leistungsangebot gegenüber
anderen Abteilungen und eine effektive Vernetzung zum ambulanten Bereich.
Deutsche Gesellschaft für Nephrologie
(DGfN)
Authors: Alscher Mark Dominik , Kribben Andreas 
Published: March 2018

ZusammenfassungDeutschland hat im internationalen Vergleich ein hervorragendes Gesundheitssystem
und speziell auch die Nephrologie als Fach ist hinsichtlich der
Patientenversorgung sehr gut aufgestellt. Beispielsweise ist der Bereich der
ambulanten Dialyseerbringung vorbildlich und war Vorreiter, was
Qualitätsmaßnahmen und deren Dokumentation betrifft. Allerdings gibt es derzeit
Risiken für das Fach der Nephrologie, welche sich einerseits aus allgemeinen
Rahmenbedingungen ergeben, anderseits mit nationalen Besonderheiten verbunden
sind. Die Deutsche Gesellschaft für Nephrologie (DGfN) repräsentiert nahezu alle
Nephrologen mit einem Organisationsgrad von mehr als 99 %. Das Fach der
Nephrologie wird gestützt durch die Jahreskongresse, Stärkung der Akademischen
Nephrologie, Kommissionen, den Verein der leitenden Krankenhausnephrologen, die
Akademie Niere, die Zusammenarbeit mit der Nierenstiftung, die Registerarbeit,
berufspolitisch durch Einwirkung auf wesentliche Regelungen der
Leistungserbringung (Bundesmantelvertrag etc.), die Zusammenarbeit mit
kommerziellen Anbietern im Kuratorium der DGfN und aktuell durch ein Gutachten
„Zukunft der Nephrologie“. Eine Fachgesellschaft muss heute zahlreiche
Aktivitäten entfalten, um bei sich verschlechternden Rahmenbedingungen für das
Fach die Grundlage für eine qualitative hochwertige Leistung, welche auch die
wissenschaftlichen Grundlagenarbeiten umfasst, zu garantieren.
Clinical Evaluation of Free-Breathing Contrast-Enhanced T1w MRI of the Liver using Pseudo Golden Angle Radial k-Space Sampling
Authors: Hedderich Dennis , Weiss Kilian , Spiro Judith , Giese Daniel , Beck Gabriele , Maintz David , Persigehl Thorsten 
Published: March 2018

Purpose Contrast-enhanced T1-weighted MR imaging of the liver is typically acquired using breath-hold techniques to reduce motion artifacts and to allow for optimal diagnostic image quality. Insufficient breath-holds during MR data collection can cause severe reduction of image quality up to the point of being non-diagnostic. The aim of this study was to evaluate the subjective and objective clinical image quality of a novel free-breathing radial k-space sampling MR technique.
Materials and Methods Consent for this study was given by the local IRB committee. 86 patients who underwent both breath-hold (BH) and free-breathing (FB) late-phase contrast T1w-FS-FFE liver MRI using conventional BH Cartesian (Cartesian-eTHRIVE) and FB “pseudo golden angle” radial k-space sampling (Radial-eTHRIVE) were included in this retrospective analysis. Subjective analysis comprised 5-point Likert scale ratings (1 = very good; 5 = non-diagnostic) for “artifact impact”, “anatomic sharpness”, “vessel sharpness”, “contrast impression”, and “overall diagnostic quality”. Relative signal intensities in different ROIs were compared between Cartesian-eTHRIVE and Radial-eTHRIVE. For statistical differences paired Wilcoxon test and paired t-test have been performed (p < 0.05).
Results The MR scan time was significantly longer for FB Radial-eTHRIVE (2 min, 54 s) compared to BH Cartesian-eTHRIVE (0 min 15 s). Cartesian-eTHRIVE demonstrated a superior subjective contrast impression and objective measurements revealed an increased lesion-to-liver-contrast for hypointense liver lesions (Hypo-LTLC: 0.33 ± 0.19 vs. 0.20 ± 0.11; p = 0.000), while no difference was observed for hyperintense liver lesions (Hyper-LTLC). Subjective evaluation showed superior anatomic sharpness ratings by both readers for Radial-eTHRIVE. Most importantly, in a subgroup analysis of patients who were unable to perform adequate breath-holds, free-breathing Radial-eTHRIVE still demonstrated good subjective image quality.
Conclusion Free-breathing, radial k-space sampling T1w MRI of the liver delivers high diagnostic image quality, especially in patients who are unable to adequately perform breath-hold maneuvers. Thus, Radial-eTHRIVE can be an important clinical alternative in patients with impaired respiration status.
Key points
Citation Format
Unerwartet lange Shuntfunktion trotz schlechter Anfangsprognose
Authors: Krönung Gerhard 
Published: March 2018

ZusammenfassungDie Maturierung einer Shuntvene ist nicht vorhersehbar. Auch zunächst nur mäßig geeignete Venen können sich,
besonders bei intraluminaler Druckerhöhung, zu guten Punktionssegmenten entwickeln. Der Erfahrungspool des
jeweiligen Operateurs spielt daher bei der Wahl zwischen einem autologen Shunt mit einer nur mäßig geeigneten
Vene und einem alloplastischen Shunt eine wesentliche Rolle.
Integrative Onkologie im Land der Morgenstille
Authors: Stoll Günther , Migeod Friedrich , Wagner Steffen , Holzhauer Peter 
Published: March 2018

ZusammenfassungIm Vergleich zur traditionellen chinesischen Medizin (TCM) wird die Eigenständigkeit der traditionellen koreanischen Medizin (TKM) nach wie vor unterschätzt, zudem ist sie stark durch die Geschichte des Landes mit langen Phasen der Fremdherrschaft und der Teilung geprägt. Eine Reise im September 2017 führte zu den Quellen der TKM, aber auch an die Front moderner integrativer Onkologie. Der Bericht erläutert die Grundzüge des koreanischen Gesundheitssystems, gibt einen Überblick über die TKM und einige ihrer Besonderheiten, insbesondere den Einsatz von Ginseng, die Pharmakoakupunktur und die Anwendung der Hyperthermie. Die Implementation integrativer Onkologie in modernen koreanischen Kliniken wird an einigen Beispielen schlaglichtartig aufgezeigt.
Selendosierung in der Onkologie – Messung, Referenz- und Optimalwerte
Authors: Stoll Günther 
Published: March 2018

ZusammenfassungImmer mehr Untersuchungen legen nahe, dass ein ausreichend hoher Selenspiegel bei Tumorpatienten dazu beiträgt, die Chancen auf eine günstige Prognose zu erhöhen. Da eine Krebserkrankung häufig mit einem Selendefizit assoziiert ist, das durch die notwendige tumorreduktive Therapie meist noch verstärkt wird, liegt es nahe, das essenzielle Spurenelement Selen zu supplementieren. Ein praktisches Behandlungsproblem besteht dabei in der Wahl der geeigneten Dosierung. Viele Labors verwenden unterschiedliche Referenzbereiche und teilweise auch nicht-valide Messmethoden. Der Optimalwert kann bisher nur aus verschiedenen Publikationen abgeschätzt werden. Außerdem beeinflussen Komorbiditäten den akuten Selenbedarf. Streng genommen sollte somit die Selendosierung für jeden Patienten individuell eingestellt werden; Richtwerte aus der Praxis geben allerdings Anhaltspunkte für eine adäquate Dosierung. Im Beitrag wird versucht, auf häufig gestellte Fragen aus der täglichen Beratungspraxis Antworten zu geben.
The acquisition of relative clauses by Mandarin heritage language children
Authors: Jia Ruiting , Paradis Johanne 
Published: March 2018

AbstractThis study examined the phenomena of incomplete acquisition, attrition, and protracted acquisition of the L1 in HL children by focusing on the comprehension and production of subject and object relative clauses (RCs) in Mandarin HL children. A cross-sectional design (study 1) and a longitudinal design (study 2) were both included. Our results showed that HL children were comparable to monolinguals for the comprehension of RCs in both study 1 and 2. For the production of RCs, although monolinguals outperformed HL children in study 1, HL children’s production of RCs was convergent with monolingual-like levels over time (study 2). We conclude that the reduced L1 input HL children receive in the host country does not necessarily lead to deficient acquisition of the L1. Perhaps for some complex structures in the L1 (e.g., RCs), HL children may need more time than monolingual children to accumulate the critical mass of input needed to acquire them.
Has There Been an Increase in the Frequency with which People who Drink in a Risky Fashion Receive Advice to Cut down on their Drinking from 1998 to 2015?
Authors: Cunningham John A. , Chaiton Michael 
Published: March 2018

Background: To assess whether there has been an increase over time in the proportion of people who drink in a risky fashion, who receive expressions of concern about their drinking or advice to cut down. Methods: Secondary analysis of the Centre for Addiction and Mental Health (CAMH) Monitor population survey, conducted annually in Ontario (participants: 18 or older) and with relevant data available from 1998 to 2015 ( N = 48,124). The proportions of participants who drank above weekly low-risk drinking levels (approximated as 15 or more drinks for males and 11 or more for females) who reported receiving expressions of concern about their drinking or advice to cut down were compared between the time periods 1998–2004, 2005–2010, and 2011–2015. Further, proportions were broken down by age group and participant sex. Results: Overall, there were low rates of participants who reported receiving advice about their drinking (16.8% of those drinking above weekly drinking levels) and no evidence of an increase across time, except among males, 34 years and under. Females drinking beyond recommended weekly guidelines were less likely than males to receive advice (11.7% versus 19.3%, respectively; P < .001). Further, older participants drinking beyond weekly guidelines were less likely than younger participants to receive advice (18–34: 16.9%; 35–54: 20.3%; 55 or older: 12.9%; P = .012). Conclusions: Given that heavy alcohol consumption is a significant contributor to the preventable burden of disease, increased emphasis is merited on finding ways to increase the frequency with which people who drink in a risky fashion receive advice to cut down.
Dynamics of the Smooth Positons of the Wadati-Konno-Ichikawa Equation*
Authors: Wang Gai-Hua , Zhang Yong-Shuai , He Jing-Song 
Published: March 2018

Abstract

We discuss a modified Wadati-Konno-Ichikawa (mWKI) equation, which is equivalent to the WKI equation by a hodograph transformation. The explicit formula of degenerated solution of mWKI equation is provided by using degenerate Darboux transformation with respect to the eigenvalues, which yields two kinds of smooth solutions possessing the vanishing and nonvanishing boundary conditions respectively. In particular, a method for the decomposition of modulus square is operated to the positon solution, and the approximate orbits before and after collision of positon solutions are displayed explicitly.
USDA Announcement Effects in Real‐Time
Authors: Adjemian Michael K , Irwin Scott H 
Published: March 2018

AbstractIn 2012, the Chicago Board of Trade eliminated a morning trading halt that coincided with the normal publication time for important USDA commodity reports. Previously, market participants had hours of halted trading time to review the information in the reports and adjust their strategies in advance of market re‐opening. We use 2009–2014 intraday grain futures market price and volume data to show that, without a trading halt, ensuing real‐time trading on USDA crop announcements exhibits noticeable volatility spikes in agricultural futures markets, but that this heightened volatility dissipates within the space of a few trading minutes. In addition, continuously‐traded markets appear to have a more difficult time distinguishing between the newsworthiness of government reports. Nevertheless, continuously traded crop markets take nearly the same time to fully absorb these shocks, following a very similar time path. Re‐imposing a timeout would necessarily lengthen the price discovery process.
Computed tomography in axial spondyloarthritis
Authors: Tan Sovira , Ward Michael M. 
Published: March 2018

Purpose of review
Computed tomography (CT) is increasingly being used in ankylosing spondylitis (AS) for imaging the spine and sacroiliac joint (SIJ). We review new insights to diagnosis and evaluation revealed by the use of CT.

Recent findings
Studies using low-dose CT in AS to detect syndesmophytes can image the entire spine, but semiquantitative scoring of the scans by human readers decreases the reliability and validity of this method. The thoracic spine is the segment most involved with syndesmophytes. Syndesmophytes are not randomly distributed around the vertebral rim but have preferred locations, which vary with the vertebral level and may be related to biomechanics. Examination of SIJ on abdominal CT scans has found structural changes of sacroiliitis in up to 35% of patients with inflammatory bowel disease. The significance of monosodium urate crystal deposition in the pelvis of axial spondyloarthritis patients without coexisting gout is uncertain.

Summary
Low-dose CT is a promising tool in AS. Studies of biomarkers or medications and their relations with syndesmophyte progression should take the thoracic spine into account. Abdominal CT scans are useful for detecting changes related to sacroiliitis.
Nationwide Trend of Sepsis: A Comparison Among Octogenarians, Elderly, and Young Adults
Authors: Lee Si-Huei , Hsu Tzu-Chun , Lee Meng-tse Gabriel , Chao Christin Chihh-Ting , Lee Wan-Chien , Lai Chi-Cheng , Lee Chien-Chang 
Published: March 2018

Objective:
We aimed to compare the sepsis incidence, mortality rates, and primary sites of infection among adult, elderly, and octogenarian patients with sepsis.

Design:
Population-based cohort study.

Setting:
The entire health insurance claims data of Taiwan, which enrolled 99.8% of the 23 million Taiwanese population.

Patients:
Sepsis patients were identified by International Classification of Diseases, 9th Edition, Clinical Modification codes for both infection and organ dysfunction from January 1, 2002, to December 31, 2012. Patients were categorized into three age groups: 1) adults (18–64 yr); 2) elderly (65–84 yr); and 3) oldest old (≥ 85 yr). The 30-day all-cause mortality was verified by a linked national death certificate database.

Interventions:
None.

Measurements and Main Results:
From 2002 to 2012, we identified 1,259,578 patients with sepsis, of which 417,328 (33.1%) were adults, 652,618 (51.8%) were elderly, and 189,632 (15.1%) were oldest old. We determined that the incidence of sepsis in the oldest old was 9,414 cases per 100,000 population on 2012, which was 31-fold greater than the adult incidence (303 cases per 100,000 population) and three-fold greater than the elderly incidence (2,908 cases per 100,000 population). Despite the increasing trend in incidence, the mortality decreased by 34% for adults, 24% for elderly, and 22% for oldest old. However, systemic fungal infection was disproportionately increased in oldest old patients (1.76% annual increase) and the elderly patients (1.00% annual increase).

Conclusion:
The incidence of sepsis is disproportionately increased in elderly and oldest old patients. Despite the increasing trend in incidence, the mortality rate in geriatric patients with sepsis has decreased. However, the increased incidence of fungal infections in the geriatric population warrants further attention.
Unusual Neuroendocrine Differentiation in a Small Round Cell Angiosarcoma: A Potential Histologic Mimicker of Superficial Ewing Sarcoma
Authors: Machado Isidro , Santonja Carlos , Huerta Victoria , Cruz Julia , Requena Celia , Requena Luis , Llombart-Bosch Antonio 
Published: March 2018

Abstract:
Neuroendocrine differentiation or aberrant expression of neuroendocrine markers is very uncommon in angiosarcomas (AS) and creates a challenging differential diagnosis with other superficial or soft tissue tumors. Herein, we report a new case of superficial AS presenting as a tumor lesion on the little finger of the right hand of a 52-year-old man. The tumor displayed CD56, chromogranin-A, and synaptophysin immunoreactivity. Tumor cells were positive for vascular markers (CD31, FLI1, ERG, D2-40, VE-cadherin, VEGR1,2, and 3), CD99, and EMA, but were negative for S100, CK (AE1/AE3), CK20, polyomavirus, and myogenic (desmin and myogenin) and melanocyte markers (melan-A and HMB45). Ki67 immunostains indicated high proliferative activity (>50%). The whole-body computed tomography did not reveal distant disease. The initial assessment considered several tumor subtypes as possible histological diagnoses, including Ewing sarcoma, Ewing-like sarcoma, Merkel cell carcinoma, and undifferentiated “small round cell sarcoma”. Fluorescence in situ hybridization analysis was negative for EWSR1 translocation and molecular analysis failed to detect any EWSR1, CIC, SYT or BCOR rearrangement. As a follow-up investigation, we tested 17 cutaneous/superficial AS for neuroendocrine markers; however, only one of these showed focal CD56 and synaptophysin expression. In conclusion, the present findings indicate that neuroendocrine differentiation is a very infrequent feature in AS. We report an AS of the finger with an uncommon histological appearance and immunohistochemical profile: predominant round cell tumor proliferation and neuroendocrine differentiation. Pathologists should be aware of these potential histological and immunohistochemical pitfalls in AS.