bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainability value creation in frugal contexts to foster Sustainable Development Goals
Authors: Arnold Marlen Gabriele 
Published: December 2018

AbstractThe 17 Sustainable Development Goals (SDGs) stress unsolved global topics such as mitigating poverty and exclusion. Inclusive approaches often highlight frugal innovations for the Base of the Pyramid and low income markets, mainly offered by private sector. In the contexts of sustainability, the private sector is both, a major driver of exclusionary processes as well as for enforcing new inclusive solutions enhancing quality of life, participation, and incomes. So it is of interest if and how the business sector contributes to enforcing SDGs. Therefore, 50 frugal innovations were analyzed for their contribution to the SDGs and their sustainability value creation patterns by content analysis. Main insights stress that social engagement is mainly value driven by small and medium enterprises and non‐governmental organizations. Institutional voids can function as drivers for multinational corporations to develop new and inclusive business models. An enforcement of the SDGs is primarily given on indirect and low level.
Effect of chemotherapy and aromatase inhibitors in the adjuvant treatment of breast cancer on glucose and insulin metabolism—A systematic review
Authors: Buch Kristian , Gunmalm Victoria , Andersson Michael , Schwarz Peter , Brøns Charlotte 
Published: December 2018

AbstractIntroductionBreast cancer (BC) is the most common cancer among women worldwide. With increasing survival rates, focus has expanded to long‐term adverse effects of adjuvant chemotherapy and/or aromatase inhibitors. Weight gain during chemotherapy has been well documented, but the underlying mechanisms remain unclear. A change in glucose and insulin metabolism is a possible consequence.MethodsWe searched PubMed on the 4th of May 2018, and found eight articles that compared measurements of glucose and insulin before and after chemotherapy and/or aromatase inhibitors in woman with BC.ResultsA general trend of increased glucose and insulin is seen and likely to be caused by weight gain and/or changes in body composition as a consequence of adjuvant treatment of BC.DiscussionDue to methodological limitations including short follow‐up times and small sample sizes, further studies are required to better describe metabolic consequences of adjuvant chemotherapy and/or aromatase inhibitors. Future studies could help identify patients in high‐risk of developing cardiometabolic disease after BC treatment.
Pharmacovigilance evaluation of the relationship between impaired glucose metabolism and BCR‐ABL inhibitor use by using an adverse drug event reporting database
Authors: Okada Naoto , Niimura Takahiro , Zamami Yoshito , Hamano Hirofumi , Ishida Shunsuke , Goda Mitsuhiro , Takechi Kenshi , Chuma Masayuki , Imanishi Masaki , Ishizawa Keisuke 
Published: December 2018

AbstractBreakpoint cluster region‐Abelson murine leukemia (BCR‐ABL) inhibitors markedly improve the prognosis of chronic myeloid leukemia. However, high treatment adherence is necessary for successful treatment with BCR‐ABL inhibitors. Therefore, an adequate understanding of the adverse event profiles of BCR‐ABL inhibitors is essential. Although many adverse events are observed in trials, an accurate identification of adverse events based only on clinical trial results is difficult because of strict entry criteria or limited follow‐up durations. In particular, BCR‐ABL inhibitor‐induced impaired glucose metabolism remains controversial. Pharmacovigilance evaluations using spontaneous reporting systems are useful for analyzing drug‐related adverse events in clinical settings. Therefore, we conducted signal detection analyses for BCR‐ABL inhibitor‐induced impaired glucose metabolism by using the FDA Adverse Event Reporting System (FAERS) and Japanese Adverse Drug Event Report (JADER) database. Signals for an increased reporting rate of impaired glucose metabolism were detected only for nilotinib use, whereas these signals were not detected for other BCR‐ABL inhibitors. Subgroup analyses showed a clearly increased nilotinib‐associated reporting rate of impaired glucose metabolism in male and younger patients. Although FAERS‐ and JADER‐based signal detection analyses cannot determine causality perfectly, our study suggests the effects on glucose metabolism are different between BCR‐ABL inhibitors and provides useful information for the selection of appropriate BCR‐ABL inhibitors.
A Two‐Year Bio‐Agronomic and Chemotaxonomic Evaluation of Wild Sicilian Myrtle (Myrtus communis L.) Berries and Leaves
Authors: Siracusa Laura , Napoli Edoardo , Tuttolomondo Teresa , Licata Mario , La Bella Salvatore , Gennaro Maria Cristina , Leto Claudio , Sarno Mauro , Sperlinga Elisa , Ruberto Giuseppe 
Published: December 2018

AbstractA collection of nine Myrtus communis samples from different localities of Sicily was evaluated. Morphological traits and production characteristics have been chosen as parameters to arrange the samples into homogeneous groups and to identify the best biotypes for possible future agro‐industrial exploitation. The plant material has been subjected to taxonomic characterization from biometric and phytochemical perspectives. Myrtle berries and leaves have been analyzed for their content in metabolites, applying a cascade extraction protocol for M. communis leaves and a single hydroalcoholic extraction for berries, whereas hydrodistillation procedures have been applied to obtain the essential oils from berries and leaves. The analyses of non‐volatile components were carried out by LC‐UV‐DAD‐ESI‐MS. All the extracts were characterized by the presence of numerous polyphenols, namely highly hydroxylated flavonols such as quercetin and myricetin; and ellagic acid detected in all samples. In addition, myrtle berries contained nine different anthocyanins, namely delphinidin, petunidin, cyanidin and malvidin derivatives. The essential oils (EOs) were analyzed by a combination of GC‐FID and GC/MS. A total of 33 and 34 components were fully characterized with the predominance of α‐pinene, myrtenyl acetate, linalool, 1,8‐cineole and linalyl acetate. All phytochemical profiles were subjected to cluster analyses, which allowed subdividing the myrtle samples in different chemical groups.
Recent Advances on Self‐Healing Materials and Batteries
Authors: Wang Hua , Wang Panpan , Feng Yuping , Liu Jie , Wang Jiaqi , Hu Mengmeng , Wei Jun , Huang Yan 
Published: December 2018

AbstractSelf‐healing is a concept to imitate the healing of biological damage and is considered to be an important property of next‐generation smart materials. With a huge breakthrough of self‐healing materials in recent years, many devices with integrated self‐healing ability are promising due to their intelligence and durability. Among them, self‐healing batteries have attracted ever‐growing interest due to their remarkable electrochemical performance and broad application prospects. In this article, the state‐of‐the‐art progress in self‐healing materials and batteries are summarized. First, this review introduces the main self‐healing mechanisms and corresponding materials. Second, various self‐healing batteries including micro and macro self‐healing, are discussed, about their self‐healing principles, fabrication techniques, and self‐healing performances. Finally, existing challenges and future opportunities are discussed in this thriving field.
Fe@Fe2P Core‐Shell Nanorods Encapsulated in Nitrogen Doped Carbon Nanotubes as Robust and Stable Electrocatalyst Toward Hydrogen Evolution
Authors: Hu Hao , Zhang Quan , Luo Fang , Guo Long , Qu Konggang , Yang Zehui , Xiao Shenglin , Xu Zhikun , Cai Weiwei , Cheng Hansong 
Published: December 2018

AbstractHere, we report an efficient hydrogen evolution reaction (HER) electrocatalyst (Fe@Fe2P/NCNT) fabricated from the phosphorization of partially oxidized iron nanorod encapsulated in nitrogen doped carbon nanotubes (Fe@Fe2O3/NCNT) synthesized from iron trichloride and melamine, which only requires ∼0 mV and 78.2 mV overpotentials to achieve cathodic current densities of 1 mA cm−2 and 10 mA cm−2 with Tafel slope of 52.2 mV dec−1 in acidic media, which exhibits higher HER electrocatalytic activity compared to Fe/NCNT requiring a overpotential of 118.5 mV to attain 10 mA cm−2 with Tafel slope of 92.3 mV dec−1. Due to the phosphorization process, additional active sites coming from Fe2P boost the electrocatalytic activity of Fe@Fe2P/NCNT resulting in decrement in overpotentials by 40.3 mV and 186 mV for 10 mA cm−2 and 50 mA cm−2 compared to Fe/NCNT electrocatalyst, respectively. Meanwhile, Fe@Fe2P/NCNT exhibits ignorable degradation in HER activity after 6000 potential cycles suggesting that the Fe@Fe2P/NCNT with superior HER activity and stability could potentially replace the benchmark Pt/C (overpotential@10 mA cm−2: 31 mV) as efficient HER electrocatalyst for water splitting.
Internal standard arithmetic implemented as relative concentration/relative calibration
Authors: Kalambet Yuri , Kozmin Yuri 
Published: December 2018

AbstractThe problems related to the internal standard method in chromatography implemented using the Response ratio/Concentrations ratio graph are discussed. The examples provided demonstrate that this method compensates for detector sensitivity variations but may not compensate for the variations in mass of the injected sample if some of calibrations are not linear through origin (directly proportional). Implementation of an alternative internal standard arithmetic––relative concentration/calibration––is described. Relative concentration is based on external standard or relative calibration dependencies. Relative calibration assumes that the calibration function of the internal standard component is accurately measured in advance. Relative concentration/calibration compensates for injected mass variations, can be applied in the case of nonlinear calibration dependencies, and allows a wide range of internal standard component concentrations; however, it does not necessarily compensate for detector response variations. It is shown that the traditional and proposed approaches provide identical predictions of concentration in the case when all calibrations are directly proportional.
Testing a biobehavioral model of fatigue before adjuvant therapy in women with breast cancer
Authors: Bower Julienne E. , Asher Arash , Garet Deborah , Petersen Laura , Ganz Patricia A. , Irwin Michael R. , Cole Steve W. , Hurvitz Sara A. , Crespi Catherine M. 
Published: December 2018

AbstractBackgroundFatigue is one of the most common and disabling side effects of cancer and its treatment. Although research typically has focused on fatigue that occurs during and after treatment, patients may experience fatigue even before treatment onset. The current study was designed to identify biobehavioral risk factors associated with fatigue before adjuvant therapy in women with early‐stage breast cancer.MethodsPatients with stage 0 to stage IIIA breast cancer (270 women) were recruited before the onset of adjuvant or neoadjuvant therapy with radiotherapy, chemotherapy, and/or endocrine therapy. Host factors that may influence fatigue were identified from an empirically based, biobehavioral model and assessed using self‐report questionnaires, medical record review, and blood collection (for genetic data). Fatigue was assessed by questionnaire. Linear regression analyses were used to evaluate the association between host factors and dimensions of fatigue, with general fatigue as the primary dimension of interest.ResultsFatigue was elevated at the pretreatment assessment compared with published controls. Bivariate analyses identified demographic, cancer‐related, and biobehavioral correlates of fatigue. In the multivariable model, predictors of general fatigue included younger age, lower educational level, lower cancer stage, and history of childhood maltreatment (all P values <.05), with the full model accounting for approximately 18.4% of the variance in fatigue. Secondary analyses identified common and specific predictors of emotional, mental, and physical dimensions of fatigue.ConclusionsAmong women who have not yet initiated treatment of breast cancer, demographic and psychosocial factors are associated with elevated fatigue and could be used to identify at‐risk patients for early intervention.
Mismatch repair deficiency identifies patients with high‐intermediate–risk (HIR) endometrioid endometrial cancer at the highest risk of recurrence: A prognostic biomarker
Authors: Backes Floor J. , Haag Jennifer , Cosgrove Casey M. , Suarez Adrian , Cohn David E. , Goodfellow Paul J. 
Published: December 2018

BackgroundThe objective of this study was to assess the correlation between mismatch repair (MMR) status, disease recurrence patterns, and recurrence‐free survival (RFS) in patients with high‐intermediate–risk (HIR) endometrioid endometrial cancer (EEC).MethodsA single‐institution chart review for consecutive patients who were diagnosed with ECC between 2007 and 2016 was undertaken. Tumor MMR status was determined for all patients based on reported findings for mutL homolog 1 (MLH1), postmeiotic segregation (PMS2), mutS homolog 2 (MSH2), and MSH6 immunohistochemistry; and defective MMR (dMMR) status was defined as the lack of expression of at least 1 of these proteins. Patients were classified with HIR EEC according to criteria used for Gynecologic Oncology Group study 249. The factors associated with recurrence were assessed by logistic regression. RFS and associated factors were assessed by Kaplan‐Meier survival analysis and Cox proportional‐hazards models.ResultsIn total, 197 patients who had HIR EEC (64 with dMMR and 133 with intact MMR [iMMR]) were identified, of whom 32 (16.2%) developed recurrent disease. The median follow‐up was 54 months. The recurrence rate for women who had dMMR was 28% compared with 10.5% for those who had iMMR (P = .002), independent of the type of adjuvant therapy they received. The increase in distant recurrences among patients who had dMMR was even more pronounced (14.1% vs 3%; P = .003). The estimated 5‐year RFS was 66% for women who had dMMR compared with 89% for those who had iMMR (P = .001). Excluding isolated vaginal recurrences, the difference in 5‐year RFS was 73.5% versus 95%, respectively (P = .0004).ConclusionsPatients who had HIR EEC with dMMR had increased rates of recurrence and decreased RFS compared with those who had HIR EEC with iMMR, despite the receipt of similar adjuvant treatment. The current findings highlight the need for alternative treatment options and the importance of MMR status as a biomarker for patients with HIR EEC.
Benign call rate and molecular test result distribution of ThyroSeq v3
Authors: Ohori N. Paul , Landau Michael S. , Carty Sally E. , Yip Linwah , LeBeau Shane O. , Manroa Pooja , Seethala Raja R. , Schoedel Karen E. , Nikiforova Marina N. , Nikiforov Yuri E. 
Published: December 2018

AbstractBackgroundThe benign call rate (BCR) is the percentage of cytomorphologically indeterminate cases with subsequent benign or negative molecular results. For rule‐out tests, the BCR is an important parameter because these molecular “negative” cases may be managed similarly to those with a benign cytology diagnosis. Although earlier versions of ThyroSeq molecular tests were less effective in excluding malignancy, the extensively expanded v3 version with a high negative predictive value is considered to represent a rule‐out test. In the current study, the authors evaluated the BCR and the overall molecular result distribution of ThyroSeq v3.MethodsAll indeterminate thyroid fine‐needle aspiration cases (except those deemed suspicious for malignancy) with available ThyroSeq v3 results from November 2017 to June 2018 were retrieved from the cytopathology files. Because the ThyroSeq v3 genomic classifier was designed for thyroid follicular‐derived lesions, cases in which parathyroid and medullary carcinoma molecular markers were detected and those that were inadequate or limited for molecular testing were excluded from the study. For the remaining cases, the indeterminate diagnoses were correlated with molecular and histologic results.ResultsAmong the 224 indeterminate cases (except those deemed suspicious for malignancy), the overall ThyroSeq v3 molecular test BCR was 74.1% (166 of 224 cases). The category of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) had higher BCRs compared with the other indeterminate diagnostic categories. RAS mutations were the most common positive results.ConclusionsThe high BCR demonstrates that ThyroSeq v3 is potentially effective in sparing the large majority of indeterminate cases with “negative” results from surgery while offering risk assessment for the positive cases and guiding clinical management.
Screening-level risk assessment of methylmercury for non-anadromous Arctic char (Salvelinus alpinus)
Authors: Barst Benjamin D. , Drevnick Paul E. , Muir Derek C.G. , Gantner Nikolaus , Power Michael , Köck Günter , Chéhab Nathalie , Swanson Heidi , Rigét Frank , Basu Niladri 
Published: December 2018

Abstract

Non-anadromous forms of Arctic char (Salvelinus alpinus), those that are restricted to lakes and rivers, typically have higher mercury (Hg) concentrations than anadromous forms, which migrate to and from the sea. Using tissue burden data from the literature and our own analyses, we performed a screening-level risk assessment of methylmercury (MeHg) for non-anadromous Arctic char. Our assessment included 1569 fish distributed across 83 sites. Site-specific mean total Hg concentrations in non-anadromous Arctic char muscle varied considerably from 0.01 to 1.13 µg/g wet weight, with 21% (17 of 83 sites) meeting or exceeding a threshold-effect level in fish of 0.33 µg/g wet weight, and 13% (11 of 83 sites) meeting or exceeding a threshold-effect level in fish of 0.5 µg/g wet weight. Of the sites in exceedance of the 0.33-µg/g threshold, 7 were located in Greenland and 10 in Canada (Labrador, Nunavut, and Yukon). All but one of these sites were located in interfrost or permafrost biomes. Maximum total Hg concentrations exceeded 0.33 µg/g wet weight at 53% of sites (40 of the 75 sites with available maximum Hg values), and exceeded 0.5 µg/g wet weight at 27% (20 of 75 sites). Collectively, these results indicate that certain populations of non-anadromous Arctic char located mainly in interfrost and permafrost regions may be at risk for MeHg toxicity. This approach provides a simple statistical assessment of MeHg risk to non-anadromous Arctic char, and does not indicate actual effects. We highlight the need for studies that evaluate the potential toxic effects of MeHg in non-anadromous Arctic char, as well as those that aid in the development of a MeHg toxic-effect threshold specific to this species of fish. Environ Toxicol Chem 2019;38:489–502. © 2018 SETAC
Bioarchaeological evidence for adaptive plasticity and constraint: Exploring life‐history trade‐offs in the human past
Authors: Temple Daniel H. 
Published: December 2018

AbstractThe Developmental Origins of Health and Disease paradigm evaluates the consequences of early life stress on health at later stages of life. Interacting with this paradigm represents a profound opportunity to leverage the lifespan and contextual approaches to human skeletal remains adopted by bioarchaeological research. Teeth and bone provide evidence for stressors experienced early in life. These events represent evidence for adaptive plasticity as Individuals survive the events through reallocation of energy to essential physiological functions, which inhibits enamel and skeletal growth. Age‐at‐death, adult body size, chronic infection, or childhood mortality may be used as covariates to better understand the physiological constraints operating on individual bodies following survival of early life stress. Contextual evidence from cemeteries provides clues to the ecological and cultural contingencies that exacerbate or mitigate the expression of these trade‐offs. Future studies should incorporate newly derived methods that provide reproducible and precise ways to evaluate early life stress, while incorporating populations that are often neglected.
Photoreactions of Sc3N@Ih‐C80 and Lu3N@Ih‐C80 with disilirane: Isolation and characterization of labile 1,2‐adducts
Authors: Kako Masahiro , Ozeki Fumiaki , Kanzawa Shinji , Fukazawa Shinpei , Sato Kumiko , Yamada Michio , Maeda Yutaka , Furukawa Makoto , Akasaka Takeshi 
Published: December 2018

AbstractThe photolysis of Sc3N@Ih‐C80 with disilirane (1,2‐disilacyclopropane) afforded the corresponding 1,2‐ and 1,4‐adducts. The relatively unstable 1,2‐product was characterized using spectroscopic and electrochemical analyses, and theoretical calculations. The relative energies of the optimized structures are consistent with the experimentally observed isomerization of the 1,2‐adduct to the 1,4‐adduct. The electron‐donating effects of the silyl groups in these products were confirmed by comparing the redox potentials of the related Sc3N@Ih‐C80 derivatives. The relative stabilities and electronic properties of the 1,2‐ and 1,4‐adducts of Lu3N@Ih‐C80 show similar aspects to those obtained for the corresponding Sc3N@Ih‐C80 derivatives.
Changes in run‐off and sediment load in the three parts of the Yellow River basin, in response to climate change and human activities
Authors: Gu Chaojun , Mu Xingmin , Gao Peng , Zhao Guangju , Sun Wenyi 
Published: December 2018

AbstractHydrological regimes in the Yellow River have changed significantly because of climate change and intensive human interventions. These changes present severe challenges to water resource utilization and ecological development. Variation of run‐off, suspended sediment load (SSL), and eight precipitation indices (P1: 0–12 mm·day−1, P12: 12–25 mm·day−1, P25: 25–50 mm·day−1, P50: P ≥ 50 mm·day−1 and corresponding rainfall day: Pd1, Pd12, Pd25, Pd50 day year−1) in three critical parts of the Yellow River basin (source region: SRYRB, upper reaches: URYRB, middle reaches: MRYRB) were investigated for the period from 1960 to 2015. The results show that run‐off and SSL significantly decreased (P < 0.01) in the URYRB and the MRYRB, whereas their decline in the SRYRB was insignificant (P > 0.05). Moreover, run‐off in the URYRB had one change point in 1987, and SSL in the URYRB as well as run‐off and SSL in the MRYRB had two change points (in the 1970s and the 1990s). Over the same period, only Pd1 and Pd12 in the SRYRB showed significant increasing trends, and an abrupt change appeared in 1981. The optimal precipitation indices for assessing the effects of precipitation on run‐off and SSL in the URYRB and MRYRB were Pd50 and P12, respectively. A double‐mass curve analysis showed that precipitation and human activities contributed to approximately 20% and 80% of the reduction in run‐off, respectively, for both the SRYRB and the MRYRB. However, the contribution rate of precipitation and human activities on SSL reduction was approximately 40% and 60% in the URYRB and 5% and 95% in the MRYRB, respectively. Human activities, primarily soil and water conservation measures and water extraction (diversion), were the main factors (>50%) that reduced the run‐off. However, the dominant driving factors for SSL reduction were soil and water conservation measures and reservoir interception, for which the contribution rate was higher than 70% in the MRYRB. This work strengthens the understanding of hydrological responses to precipitation change and provides a useful reference for regional water resource utilization.