bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated moth flight analysis in the vicinity of artificial light
Authors: Gaydecki P. 
Published: May 2018

AbstractInstrumentation and software for the automated analysis of insect flight trajectories is described, intended for quantifying the behavioural dynamics of moths in the vicinity of artificial light. For its time, this moth imaging system was relatively advanced and revealed hitherto undocumented insights into moth flight behaviour. The illumination source comprised a 125 W mercury vapour light, operating in the visible and near ultraviolet wavelengths, mounted on top of a mobile telescopic mast at heights of 5 and 7.1 m, depending upon the experiment. Moths were imaged in early September, at night and in field conditions, using a ground level video camera with associated optics including a heated steering mirror, wide angle lens and an electronic image intensifier. Moth flight coordinates were recorded at a rate of 50 images per second (fields) and transferred to a computer using a light pen (the only non-automated operation in the processing sequence). Software extracted ground speed vectors and, by instantaneous subtraction of wind speed data supplied by fast-response anemometers, the airspeed vectors. Accumulated density profiles of the track data revealed that moths spend most of their time at a radius of between 40 and 50 cm from the source, and rarely fly directly above it, from close range. Furthermore, the proportion of insects caught by the trap as a proportion of the number influenced by the light (and within the field of view of the camera) was very low; of 1600 individual tracks recorded over five nights, a total of only 12 were caught. Although trap efficiency is strongly dependent on trap height, time of night, season, moonlight and weather, the data analysis confirmed that moths do not exhibit straightforward positive phototaxis. In general, trajectory patterns become more complex with reduced distance from the illumination, with higher recorded values of speeds and angular velocities. However, these characteristics are further qualified by the direction of travel of the insect; the highest accelerations tended to occur when the insect was at close range, but moving away from the source. Rather than manifesting a simple positive phototaxis, the trajectories were suggestive of disorientation. Based on the data and the complex behavioural response, mathematical models were developed that described ideal density distribution in calm air and light wind speed conditions. The models did not offer a physiological hypothesis regarding the behavioural changes, but rather were tools for quantification and prediction. Since the time that the system was developed, instrumentation, computers and software have advanced considerably, allowing much more to be achieved at a small fraction of the original cost. Nevertheless, the analytical tools remain useful for automated trajectory analysis of airborne insects.
RICHARD HOOKER AS POLITICAL NATURALIST
Authors: KENNEDY SIMON P. 
Published: May 2018

AbstractRichard Hooker's understanding of political society has engendered significant debate. Does he hold that society is natural, in keeping with his commitment to aspects of Aristotelianism? Or does he believe that society is conventional, leading somehow to a social contractarian conception of society? My contention is that he is a political naturalist, though his naturalism is tempered by his Augustinian theological anthropology. Hooker emphasizes human sin in his account of the nature and purpose of civil government, and gives humankind agency in the establishment of society. But, ultimately, he considers political life to be natural to the human condition. In this way, Hooker navigates avia mediabetween Aristotelian naturalism and conventionalism.
ENCOMPASSING JUDAISM: ELMESSIRI AND THE “ISLAMIC HUMANIST” SELF
Authors: Woltering Robbert A.F.L. 
Published: May 2018

AbstractDespite the weight of his work and his prominence in Arabic public debate, the Egyptian public intellectual ʿAbd al-Wahhab Elmessiri (1938–2008) has not been the subject of much serious study. In this article, I show that Elmessiri's oeuvre offers a rich and creative perspective on both Judaism and Zionism. Studying Elmessiri from the perspective of identity/alterity studies, I argue that his representation of Judaism qualifies as what Gerd Baumann and André Gingrich call “encompassment by hierarchical subsumption.” The article offers an analysis of the discursive logic behind this image of Judaism and its connection to Elmessiri's anti-Zionist agenda, rejection of anti-Semitism, and critique of Western modernity.
THE PARTY OF GOD: THE ASSOCIATION OF ALGERIAN MUSLIM ʿULAMAʾ IN CONTENTION WITH THE NATIONALIST MOVEMENT AFTER WORLD WAR II
Authors: Watanabe Shoko 
Published: May 2018

AbstractScholarship has long held that Islamic reform was a preparatory stage for nationalism in the Muslim world. In challenge to this view, this article shows how in the context of 20th-century Algeria Islamic reformers and nationalists continued to maintain distinct political ideas, visions, and projects. The article examines the internal framework of the Association of Algerian Muslim ʿUlamaʾ, an Islamic reform movement founded in 1931 when Algeria was under French colonial rule, and its interactions with other local movements, especially the Algerian nationalist movement. Through a comparison of the discourse of the Algerian ʿulamaʾ to that of the nationalists, it argues that while both groups claimed to be successors of Jamal al-Din al-Afghani, their understanding of politics (siyāsa) was different. Whereas the ʿulamaʾ associated politics with their own spiritual leadership, the nationalists associated it with institutions. The study situates these distinct visions within the post–World War II historical context, in which the expanding nationalist movement undermined the ʿulamaʾ’s popular appeal.
Legalization and the Legitimation of the Use of Force: Revisiting Kosovo
Authors: Nuñez-Mietz Fernando G. 
Published: May 2018

AbstractRecent works on the role of argumentation in international politics have enriched our understanding of the discursive construction of international legitimacy. Many scholars have recognized the pervasiveness and privileged status of legal claims. Building on these insights, I advance the proposition that the international legitimacy of the use of force has legalized. Legalization implies that successful (de-)legitimation depends on the strategic use of international law, and that alternative legitimacy discourses (such as morality) have been marginalized and play a negligible role in the construction of legitimacy. Thus, the use of force is legitimate to the extent that it conforms to international law. I test this “legalization thesis” against the “hard” case of NATO's intervention in Kosovo in 1999. By revisiting the arguments used by state representatives, I show that, as expected in a legalized legitimacy system and contrary to what has become common knowledge about this case, legitimacy was gained through, not despite, international law. I analyze NATO's strategy of legitimation in detail and reconstruct it as a set of seven strategic moves, all of them appealing exclusively to the international legal discourse.
Proof-relevant unification: Dependent pattern matching with only the axioms of your type theory
Authors: COCKX JESPER , DEVRIESE DOMINIQUE 
Published: May 2018

AbstractDependently typed languages such as Agda, Coq, and Idris use a syntactic first-order unification algorithm to check definitions by dependent pattern matching. However, standard unification algorithms implicitly rely on principles such asuniqueness of identity proofsandinjectivity of type constructors. These principles are inadmissible in many type theories, particularly in the new and promising branch known as homotopy type theory. As a result, programs and proofs in these new theories cannot make use of dependent pattern matching or other techniques relying on unification, and are as a result much harder to write, modify, and understand. This paper proposes a proof-relevant framework for reasoning formally about unification in a dependently typed setting. In this framework, unification rules compute not just a unifier but also a corresponding soundness proof in the form of anequivalencebetween two sets of equations. By rephrasing the standard unification rules in a proof-relevant manner, they are guaranteed to preserve soundness of the theory. In addition, it enables us to safely add new rules that can exploit the dependencies between the types of equations, such as rules for eta-equality of record types and higher dimensional unification rules for solving equations between equality proofs. Using our framework, we implemented a complete overhaul of the unification algorithm used by Agda. As a result, we were able to replace previousad-hocrestrictions with formally verified unification rules, fixing a substantial number of bugs in the process. In the future, we may also want to integrate new principles with pattern matching, for example, the higher inductive types introduced by homotopy type theory. Our framework also provides a solid basis for such extensions to be built on.
Contribution of Family Relatedness to Neurobehavioral Comorbidities in Idiopathic Childhood Epilepsies
Authors: Almane Dace N. , Zhao Qianqian , Rathouz Paul J. , Hanson Melissa , Jackson Daren C. , Hsu David A. , Stafstrom Carl E. , Jones Jana E. , Seidenberg Michael , Koehn Monica , Hermann Bruce P. 
Published: May 2018

AbstractObjectives:Rates of cognitive, academic and behavioral comorbidities are elevated in children with epilepsy. The contribution of environmental and genetic influences to comorbidity risk is not fully understood. This study investigated children with epilepsy, their unaffected siblings, and controls to determine the presence and extent of risk associated with family relatedness across a range of epilepsy comorbidities.Methods:Participants were 346 children (8–18 years),n=180 with recent-onset epilepsy, their unaffected siblings (n=67), and healthy first-degree cousin controls (n=99). Assessments included: (1) Child Behavior Checklist/6-18 (CBCL), (2) Behavior Rating Inventory of Executive Function (BRIEF), (3) history of education and academic services, and (4) lifetime attention deficit hyperactivity disorder (ADHD) diagnosis. Analyses consisted of linear mixed effect models for continuous variables, and logistic mixed models for binary variables.Results:Differences were detected between the three groups of children across all measures (p<.001). For ADHD, academic problems, and executive dysfunction, children with epilepsy exhibited significantly more problems than unaffected siblings and controls; siblings and controls did not differ statistically significantly from each other. For social competence, children with epilepsy and their unaffected siblings displayed more abnormality compared with controls, with no statistically significant difference between children with epilepsy and unaffected siblings. For behavioral problems, children with epilepsy had more abnormality than siblings and controls, but unaffected siblings also exhibited more abnormalities than controls.Conclusions:The contribution of epilepsy and family relatedness varies across specific neurobehavioral comorbidities. Family relatedness was not significantly associated with rates of ADHD, academic problems and executive dysfunction, but was associated with competence and behavioral problems. (JINS, 2018,24, 1–9)
Intense Cross‐Tail Field‐Aligned Currents in the Plasma Sheet at Lunar Distances
Authors: Xu Sixue , Runov Andrei , Artemyev Anton , Angelopoulos Vassilis , Lu Quanming 
Published: May 2018

AbstractField‐aligned currents in the Earth's magnetotail, typically observed at the plasma sheet boundary layer, are believed to be driven by transient plasma flows and strong plasma pressure gradients at equatorial footpoints. Magnetotail currents (transverse to the magnetic field), usually observed within the plasma sheet, flow duskward (cross‐tail) and are believed to be diamagnetic. These two current systems, field aligned and transverse, can be easily distinguished because of their differing propagation direction. By statistically analyzing magnetotail current sheet crossings by the two lunar‐orbiting Acceleration, Reconnection, Turbulence and Electrodynamics of Moon's Interaction with the Sun spacecraft (probes), we demonstrate that the duskward magnetotail current in the lunar distance magnetotail (∼55–65RE) can, at times, be predominantly field aligned. In about half the current sheet crossings examined, there is a significant equatorial, unidirectional cross‐tail magnetic field component near the peak cross‐tail current density. Because of the alignment of the magnetic field with the cross‐tail current, a significant part of the total cross‐tail current (∼1 to 10 nA/m2) is field aligned. This magnetic field component contributes significantly to the vertical pressure balance and is therefore important for plasma sheet dynamic stability. The generation mechanism and closure of the resultant field‐aligned current system and its role in the dynamic stability of the current sheet are important to investigate further.
Polygenic pleiotropy and potential causal relationships between educational attainment, neurobiological profile, and positive psychotic symptoms
Authors: Lin Yen-Feng , Chen Chia-Yen , Öngür Dost , Betensky Rebecca , Smoller Jordan W. , Blacker Deborah , Hall Mei-Hua 
Published: May 2018

AbstractEvent-related potential (ERP) components have been used to assess cognitive functions in patients with psychotic illness. Evidence suggests that among patients with psychosis there is a distinct heritable neurophysiologic phenotypic subtype captured by impairments across a range of ERP measures. In this study, we investigated the genetic basis of this “globally impaired” ERP cluster and its relationship to psychosis and cognitive abilities. We applied K-means clustering to six ERP measures to re-derive the globally impaired (n = 60) and the non-globally impaired ERP clusters (n = 323) in a sample of cases with schizophrenia (SCZ = 136) or bipolar disorder (BPD = 121) and healthy controls (n = 126). We used genome-wide association study (GWAS) results for SCZ, BPD, college completion, and childhood intelligence as the discovery datasets to derive polygenic risk scores (PRS) in our study sample and tested their associations with globally impaired ERP. We conducted mediation analyses to estimate the proportion of each PRS effect on severity of psychotic symptoms that is mediated through membership in the globally impaired ERP. Individuals with globally impaired ERP had significantly higher PANSS-positive scores (β = 3.95, P = 0.005). The SCZ-PRS was nominally associated with globally impaired ERP (unadjusted P = 0.01; R2 = 3.07%). We also found a significant positive association between the college-PRS and globally impaired ERP (FDR-corrected P = 0.004; R2 = 6.15%). The effect of college-PRS on PANSS positivity was almost entirely (97.1%) mediated through globally impaired ERP. These results suggest that the globally impaired ERP phenotype may represent some aspects of brain physiology on the path between genetic influences on educational attainment and psychotic symptoms.
Activated dendritic cells modulate proliferation and differentiation of human myoblasts
Authors: Ladislau Leandro , Portilho Débora M. , Courau Tristan , Solares-Pérez Alhondra , Negroni Elisa , Lainé Jeanne , Klatzmann David , Bonomo Adriana , Allenbach Yves , Benveniste Olivier , Riederer Ingo , Savino Wilson , Mouly Vincent , Butler-Browne Gillian , Benjamim Claudia F. 
Published: May 2018

AbstractIdiopathic Inflammatory Myopathies (IIMs) are a heterogeneous group of autoimmune diseases affecting skeletal muscle tissue homeostasis. They are characterized by muscle weakness and inflammatory infiltration with tissue damage. Amongst the cells in the muscle inflammatory infiltration, dendritic cells (DCs) are potent antigen-presenting and key components in autoimmunity exhibiting an increased activation in inflamed tissues. Since, the IIMs are characterized by the focal necrosis/regeneration and muscle atrophy, we hypothesized that DCs may play a role in these processes. Due to the absence of a reliable in vivo model for IIMs, we first performed co-culture experiments with immature DCs (iDC) or LPS-activated DCs (actDC) and proliferating myoblasts or differentiating myotubes. We demonstrated that both iDC or actDCs tightly interact with myoblasts and myotubes, increased myoblast proliferation and migration, but inhibited myotube differentiation. We also observed that actDCs increased HLA-ABC, HLA-DR, VLA-5, and VLA-6 expression and induced cytokine secretion on myoblasts. In an in vivo regeneration model, the co-injection of human myoblasts and DCs enhanced human myoblast migration, whereas the absolute number of human myofibres was unchanged. In conclusion, we suggest that in the early stages of myositis, DCs may play a crucial role in inducing muscle-damage through cell–cell contact and inflammatory cytokine secretion, leading to muscle regeneration impairment.
SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons
Authors: Romeo-Guitart David , Leiva-Rodríguez Tatiana , Espinosa-Alcantud María , Sima Núria , Vaquero Alejandro , Domínguez- Martín Helena , Ruano Diego , Casas Caty 
Published: May 2018

AbstractSirtuin 1 (SIRT1) activity is neuroprotective, and we have recently demonstrated its role in the retrograde degenerative process in motoneurons (MNs) in the spinal cord of rats after peripheral nerve root avulsion (RA) injury. SIRT2 has been suggested to exert effects opposite those of SIRT1; however, its roles in neurodegeneration and neuron response after nerve injury remain unclear. Here we compared the neuroprotective potentials of SIRT1 activation and SIRT2 inhibition in a mouse model of hypoglossal nerve axotomy. This injury induced a reduction of around half MN population within the hypoglossal nucleus by a non-apoptotic neurodegenerative process triggered by endoplasmic reticulum (ER) stress that resulted in activation of the unfolded protein response mediated by IRE1α and XBP1 by 21 days post injury. Both SIRT1 activation with NeuroHeal and SIRT2 inhibition with AK7 protected NSC-34 motor neuron-like cells against ER stress in vitro. In agreement with the in vitro results, NeuroHeal treatment or SIRT1 overexpression was neuroprotective of axotomized hypoglossal MNs in a transgenic mouse model. In contrast, AK7 treatment or SIRT2 genetic depletion in mice inhibited damaged MN survival. To resolve the in vitro/in vivo discrepancies, we used an organotypic spinal cord culture system that preserves glial cells. In this system, AK7 treatment of ER-stressed organotypic cultures was detrimental for MNs and increased microglial nuclear factor-κB and the consequent transcription of cytotoxic pro-inflammatory factors similarly. The results highlight the importance of glial cells in determining the neuroprotective impact of any treatment.
MiR-455-3p inhibits the degenerate process of chondrogenic differentiation through modification of DNA methylation
Authors: Sun Hao , Zhao Xiaoyi , Zhang Chengyun , Zhang Ziji , Lun Jiayong , Liao Weiming , Zhang Zhiqi 
Published: May 2018

AbstractThe aim of this work was to determine whether miR-455-3p regulates DNA methylation during chondrogenic differentiation of hMSCs. The expression of miR-455-3p and de novo methyltransferase DNMT3A was assessed in micromass culture of hBMSCs, which induced chondrogenic differentiation in vitro, and in E16.5 mice in vivo. A luciferase reporter assay was used to confirm whether miR-455-3p directly targets DNMT3A by interaction with the 3′-UTR. Using an Illumina Infinium Methylation EPIC microarray, genome-wide DNA methylation of hBMSCs with or without overexpressed miR-455-3p was examined for 28 days during induced chondrogenic differentiation. Here, we showed that miR-455-3p was more expressed during the middle stage of hBMSC chondrogenic differentiation, and less expressed in the late stage. DNMT3A was less expressed in the middle stage and more expressed in the late stage, and was also more expressed in the palms of miR-455-3p deletion mice compared to those of wild-type mice. The luciferase reporter assay demonstrated that miR-455-3p directly targets DNMT3A 3′-UTR. miR-455-3p overexpression inhibits the degenerate process during chondrogenic differentiation, while deletion of miR-455-3p in mice accelerated cartilage degeneration. Genome-wide DNA methylation analysis showed miR-455-3p overexpression regulates DNA methylation of cartilage-specific genes. GO analysis revealed PI3K-Akt signaling pathway was most hypomethylated. Our data show that miR-455-3p can regulate hMSC chondrogenic differentiation by affecting DNA methylation. Overexpression of miR-455-3p and DNA methylation inhibitors can thus potentially be utilized to optimize chondrogenic differentiation.
Plasma microRNA panel is a novel biomarker for focal segmental glomerulosclerosis and associated with podocyte apoptosis
Authors: Xiao Bin , Wang Li-Na , Li Wei , Gong Li , Yu Ting , Zuo Qian-Fei , Zhao Hong-Wen , Zou Quan-Ming 
Published: May 2018

AbstractFocal segmental glomerulosclerosis (FSGS) is a frequent glomerular disease, and is the common cause of nephrotic syndrome. However, there is no validated diagnostic blood biomarker for FSGS. Here, we performed a real-time PCR-based high-throughput miRNA profiling to identify the plasma signature for FSGS. We found four miRNAs (miR-17, miR-451, miR-106a, and miR-19b) were significantly downregulated in the plasma of FSGS patients (n = 97) compared with healthy controls (n = 124) in the training, validation, and blinded-test phases. The miRNA panel produced an AUC value of 0.82, and was associated with FSGS severity and histologic classification. A three-miRNA panel, including miR-17, miR-451, and miR-106a was related to FSGS remission. Furthermore, the downregulation of plasma-miRNA signature was not detected in disease controls (n = 119) such as IgA nephropathy (IgAN), mesangial proliferative glomerulonephritis (MSPGN), and membranous nephropathy (MN), and the miRNA panel discriminated between FSGS and disease controls. Pathway analysis showed that the four-miRNA panel may cooperatively regulate the pathways involved in the development of FSGS, such as apoptosis. We identified that phosphatase and tensin homolog (PTEN), Bcl-2-like protein 11 (BCL2L11), and chemokine (C-X-C motif) ligand 14 (CXCL14) were targets of miR-106a in human podocyte. Additionally, miR-106a overexpression suppressed podocyte apoptosis in vitro and the downregulation of four-miRNA panel probably resulted in the enhanced apoptosis in podocyte during FSGS development. Taken together, our data show that the plasma-miRNA panel is a potential independent diagnostic and prognostic factor for FSGS. Above miRNAs are involved in FSGS pathogenesis through regulating podocyte apoptosis.