bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of pulverized oyster mushroom (Pleurotus ostreatus) on diarrhea incidence, growth performance, immunity, and microbial composition in piglets
Authors: Adams Seidu , Che Dongsheng , Hailong Jiang , Zhao Bao , Rui Han , Danquah Kofi , Qin Guixin 
Published: January 2019

AbstractBACKGROUNDPleurotus ostreatus mushroom (POM) is an edible mushroom with rich nutritional components and vital pharmacological properties. The present study comprised 100 cross‐bred piglets, weaned at 28 days old, who were randomly assigned to four POM diets with five replicates per diet and five piglets per pen.RESULTSPOM supplementation (P < 0.05) decreased the incidence of diarrhea, and also increased the average daily feed intake and average daily gain of pigs. Fecal acetate, butyrate and propionate increased with the addition of POM. Interleukin‐2, immunoglobulin G, immunoglobulin M, tumor necrosis factor‐α and immunoglobulin A increased (P < 0.05) with the addition of POM. The 16S rDNA sequencing results showed that the Bacteroidetes and Firmicutes were the dominant microbial strains in the fecal samples, irrespective of POM supplementation. Shannon diversity, whole tree phylogenetic diversity, observed species and Chao1 analysis exhibited significant variation in species richness across the treatments. Principal coordinates analysis showed a significant (P < 0.1) increase in the microbial communities amongst all of the treatment groups.CONCLUSIONThe results of the present study suggest that the supplementation of POM in the diet of piglets might increase feed consumption, gut microbial composition and diversity, as well as short‐chain fatty acids synthesis, consequently preventing the occurrence of diarrhea and increasing the growth of piglets. © 2019 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Optimizing reproductive opportunity for Florida grasshopper sparrows: When to burn?
Authors: Hewett Ragheb Erin L. , Miller Karl E. , Kiltie Richard A. 
Published: January 2019

ABSTRACTThe critically endangered Florida grasshopper sparrow (Ammodramus savannarum floridanus) is dependent on dry prairies managed with prescribed fires that are applied every 1–3 years. Timing of prescribed fires shifted from predominantly the dormant season (Jan–Mar) to the transition (Apr–Jun) and growing (Jul–Aug) seasons starting in the early 2000s to better mimic natural fire regimes. Populations have continued to decline, however, and the presumption that natural fire regimes are beneficial to the small extant Florida grasshopper sparrow populations needs to be evaluated. We monitored 167 Florida grasshopper sparrow nests across 6 fire treatments at Three Lakes Wildlife Management Area, Osceola County, Florida, USA, 2013–2016, and investigated the role of fire season and interval on clutch initiation date, nest site selection, nest survival, productivity, and nestling mass. Clutch initiation was delayed by ≥33 days in prairies burned during the current transition season and we found no nests in prairies burned during the current growing season. Transition season burns also overlapped with the early breeding season, which could result in the destruction of nests. Clutches were larger at the beginning of the breeding season and nestling mass was highest in the middle of the breeding season, indicating that early and mid‐season nests may be more valuable to annual fecundity than late‐season nests. Florida grasshopper sparrows nested in prairies burned in the current dormant season or previous growing season more than expected based on their availability and as expected or less than expected in prairies burned in the current transition season, previous transition season, previous dormant season, or >2 years ago. However, we found no effect of fire treatment on daily nest survival, clutch size, number of fledglings per successful nest, or nestling mass. We recommend dormant season burning in prairies occupied by Florida grasshopper sparrows to increase reproductive potential given the subspecies’ small population and the importance of each nest attempt to population growth. We recommend transition or growing season burns in unoccupied adjacent prairies to maintain high‐quality dry prairie for nesting in future years. Prescribed fire management goals for Florida grasshopper sparrow populations should be guided by demographic responses rather than natural fire regimes. © 2019 The Wildlife Society.
Employing Heterocyclic Hypervalent Iodine Compounds with ICl Bonds as Initiators and Chain Transfer Agents in the Synthesis of Branched Polymers
Authors: Cao Yakun , Kumar Rajesh , Tsarevsky Nicolay V. 
Published: January 2019

AbstractHeterocyclic hypervalent (HV) iodine(III) compounds with ICl bonds and various substituents at the N atom are synthesized and found to be very efficient chain transfer agents in the polymerization of styrene with transfer coefficients exceeding that of CCl4 by 2–3 orders of magnitude, depending on the structure. The chain transfer rate coefficients are also determined. Due to the presence of thermally labile HV bonds, the compounds degrade homolytically upon heating and can initiate radical polymerization. For instance, 1‐chloro‐2‐hexyl‐1,2‐benziodazol‐3(2H)‐one, is used in the polymerization of styrene, which yields low molecular weight polymers with alkyl chloride groups at the α‐ (initiation) and the ω‐chain ends (transfer). Chain‐end functionalization reactions with azide and chain extension under low‐catalyst‐concentration atom transfer radical polymerization (ATRP) conditions of the prepared telechelic polymers are carried out. The same initiator/chain transfer agent is successfully employed in the synthesis of highly branched polymers with multiple alkyl chloride‐type chain ends when added to mixtures of styrene and 1,4‐divinylbenzene containing 10–80 mol% of the divinyl crosslinker, or even pure crosslinker. In all cases, soluble hyperbranched polymers are obtained up to moderate monomer conversions. The effects of crosslinker and HV iodine(III) compound concentrations on the polymerization outcome are studied systematically.
A systematic review with meta‐analysis on functional changes associated with neck pain in adolescents
Authors: Andias Rosa , Silva Anabela G. 
Published: January 2019

AbstractBackgroundNeck pain (NP) is highly prevalent in young people, but there has been no systematic review synthetizing the functional changes associated with this in adolescents. The aim of the present study was to identify and assess critically the evidence on the functional changes associated with NP in adolescents, specifically for: (a) posture; (b) postural control; (c) range of motion; (d) proprioception; (e) muscle function; and (f) sensory threshold.MethodsWe searched PubMed, ScienceDirect, Web of Science, PEdro, Scielo, Scopus and Academic Search Premier databases for relevant studies. Two reviewers screened studies for inclusion and assessed the quality of the included studies. One reviewer extracted relevant data from the included studies. A meta‐analysis was performed for studies that measured forward head posture (FHP).ResultsTen studies were included and a total of 15 comparisons for different variables were made. When compared with adolescents without NP, those with NP showed no differences in cervicothoracic posture or FHP. However, statistically significant differences were found for range of motion: weighted mean difference (WMD) from –14.0° (–21.1° to –1.1°) to 9.4° (2.8° to 16.0°); flexor muscle endurance: WMD –11.4 (–21.8 to –0.9) s; extensor muscle endurance: WMD –42.0 (–77.8 to –6.3) s; joint repositioning error for right and left rotation: WMD 1.9° (0.8° to 2.9°) and 2.4° (1.3° to 3.5°), respectively; and pressure pain threshold: WMD from –15.6 (–18.5 to –12.8) to –9.3 (–11.3 to 7.2) N/ cm².ConclusionThere is very limited to limited evidence that there is no difference in posture between adolescents with and without NP, and that there is a difference for range of motion, muscle function, proprioception and pressure pain threshold.
The immunological consequences of radiation‐induced DNA damage
Authors: Wilkins Anna C , Patin Emmanuel C , Harrington Kevin J , Melcher Alan A 
Published: January 2019

AbstractHistorically, our understanding of the cytotoxicity of radiation has centred on tumour cell‐autonomous mechanisms of cell death. Here, tumour cell death occurs when a threshold number of radiation‐induced non‐reparable double‐stranded DNA breaks is exceeded. However, in recent years, the importance of immune mechanisms of cell death has been increasingly recognised, as well as the impact of radiotherapy on non‐malignant cellular components of the tumour microenvironment. Conserved antiviral pathways that detect foreign nucleic acid in the cytosol and drive downstream interferon (IFN) responses via the cyclic guanosine monophosphate–adenosine monophosphate synthase/stimulator of IFN genes (cGAS/STING) pathway are key components of the immune response to radiation‐induced DNA damage. In preclinical models, acute induction of a type 1 IFN response is important for both direct and abscopal tumour responses to radiation. Inhibitors of the DNA damage response show promise in augmenting this inflammatory IFN response. However, a substantial proportion of tumours show chronic IFN signalling prior to radiotherapy, which paradoxically drives immunosuppression. This chronic IFN signalling leads to treatment resistance, and heterotypic interactions between stromal fibroblasts and tumour cells contribute to an aggressive tumour phenotype. The effect of radiotherapy on myeloid cell populations, particularly tumour‐associated macrophages, has an additional impact on the immune tumour microenvironment. It is not yet clear how the above preclinical findings translate into a human context. Human tumours show greater intratumoural genomic heterogeneity and more variable levels of chromosomal instability than experimental murine models. High‐quality translational studies of immunological changes occurring during radiotherapy that incorporate intrinsic tumour biology will enable a better understanding of the immunological consequences of radiation‐induced DNA damage in patients. Copyright © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
How enhancing information and communication technology has affected inequality in Africa for sustainable development: An empirical investigation
Authors: Asongu Simplice A. , Odhiambo Nicholas M. 
Published: January 2019

AbstractThis study examines if enhancing information and communication technology reduces inequality in 48 countries in Africa for the periods 2004–2014. Three inequality indictors are used, namely, the Gini coefficient, Atkinson index, and Palma ratio. The adopted information and communication technology indicators include mobile phone penetration, internet penetration, and fixed broadband subscriptions. The empirical evidence is based on the generalised method of moments. Enhancing internet penetration and fixed broadband subscriptions has a net effect on reducing the Gini coefficient and the Atkinson index, whereas increasing mobile phone penetration and internet penetration reduces the Palma ratio. Policy implications are discussed in the light of challenges to Sustainable Development Goals.
The overlooked role of discourse in breaking carbon lock‐in: The case of the German energy transition
Authors: Buschmann Pia , Oels Angela 
Published: January 2019

Over the last 15 years, research on carbon lock‐in has investigated why decarbonization evolves so slowly in Western industrialized countries. In this paper, we argue that the role of discourses has been overlooked in the literature on carbon lock‐in. We argue that discourses are both part of lock‐in mechanisms and, using the concept of discursive turning points, important factors in explaining change. This implies that we need to carefully investigate the dominant discourses that constitute and justify the very technologies, institutions and behaviors of the status quo. For the case of the German energy transition, we demonstrate the importance of discursive turning points for overcoming carbon lock‐in, based on a literature review. Germany's long‐standing lock‐in of fossil fuels and nuclear power was undermined by the rise of the energy transition discourse. This discourse transitioned from a very marginal position to dominance through a number of factors, winning against the energy mix discourse. Over time the energy transition discourse became de‐radicalized. Coal has been able to defend its role in the German energy mix in the name of affordability and energy security. While renewables continue to grow, this happens alongside a remaining carbon lock‐in. We conclude that discursive lock‐in and discursive turning points are useful analytical tools that help to explain how the transition to renewable energies unfolds. In future research, the interaction between discursive lock‐ins and other types of lock‐in should be investigated.This article is categorized under:
The Carbon Economy and Climate Mitigation > Decarbonizing Energy and/or Reducing Demand
Policy and Governance > Governing Climate Change in Communities, Cities, and Regions
Time‐accurate blade surface static pressure behaviour on a rotating H‐Darrieus wind turbine
Authors: Du Longhuan , Ingram Grant , Dominy Robert G. 
Published: January 2019

AbstractTime‐accurate blade pressure distributions on a rotating H‐Darrieus wind turbine at representative tip speed ratios during start‐up are presented here, which allow blade dynamic stall and laminar separation bubbles to be observed clearly and which provide a rare experimental demonstration of the flow curvature effect inherent in H‐Darrieus turbine operation. The convection of a dynamic stall vortex along the blade surface at high reduced frequency has also been clearly identified. This study provides new information of the complex aerodynamics of the vertical axis wind turbines (VAWTs) and provides unique experimental data to validate the transient blade static surface pressure distribution predicted by CFD models. To the best of the authors' knowledge, this is the first time that the instantaneous pressure variation around the blade has been measured and recorded directly for an H‐Darrieus wind turbine.
Problems of problem-based learning: Towards transformative critical pedagogy in medical education
Authors: Cavanagh Alice , Vanstone Meredith , Ritz Stacey 
Published: January 2019

Problem-based medical education is based in a biomedical worldview that works to entrench deterministic ways of thinking about socioculturally-influenced health disparities in the minds of medical trainees. This perspective paper considers the utility of Paolo Freire’s critical pedagogy as a means of redressing this issue, as it may enable medical learners to perceive and address the social sources of illness that shape their patients’ lives. With an eye to advancing health equity, and educating health professionals who are responsive to marginalized and vulnerable communities, this paper considers how a problem-posing medical education could redefine physicians’ relationships to knowledge, identity, and to their patients.
FDA position statement “Early Alzheimer's disease: Developing drugs for treatment, Guidance for Industry”
Authors: Sabbagh Marwan N. , Hendrix Suzanne , Harrison John E. 
Published: January 2019

AbstractDespite billions of dollars invested in clinical trials to develop novel therapeutics for Alzheimer's disease, no approved treatments have been developed in the past 15 years. In that span, new classes of drugs have been developed and tested, including monoclonal antibodies, γ‐secretase modulators, γ‐secretase inhibitors, BACE inhibitors, RAGE inhibitors, nicotinic agonists, 5HT6 antagonists, and others. The one constant for all of these clinical trials programs is the use of the ADAS‐cog as the primary scale to determine efficacy. The question that needs to be considered is whether it is the target engagement of the drug or the clinical trial measure testing the efficacy. The FDA put out a new position statement in 2018 informing the field on possible considerations for demonstrating efficacy to open the path for approval. Here, we propose and comment on a variety of approaches that are alternatives to the ADAS for FDA‐specified stage 3 and 4 Alzheimer's disease. These novel outcomes are being validated in current clinical trials and could be used as efficacy measures moving forward.
Effects of offering lupins/triticale and vetch/barley silages alone or in combination with grass silage on animal performance, meat quality and the fatty acid composition of lean meat from beef cattle
Authors: Kennedy P. C. , Dawson L. E. R. , Lively F. O. , Steen R. W. J. , Fearon A. M. , Moss B. W. , Kilpatrick D. J. 
Published: January 2019

AbstractAn experiment was carried out to examine the effects of offering beef steers grass silage (GS) as the sole forage, lupins/triticale silage (LTS) as the sole forage, a mixture of LTS and GS at a ratio of 70:30 on a dry matter (DM) basis, vetch/barley silage (VBS) as the sole forage, a mixture of VBS and GS at a ratio of 70:30 on a DM basis, giving a total of five silage diets. Each of the five silage diets was supplemented with 2 and 5 kg of concentrates/head/day in a 5 × 2 factorial design to evaluate the five silages at two levels of concentrate intake and to examine possible interactions between silage type and concentrate intake. A total of 80 beef steers were used in the 122-day experiment. The GS was well preserved while the whole crop cereal/legume silages had high ammonia-nitrogen (N) concentrations, low lactic acid concentrations and low butyric acid concentrations For GS, LTS, LTS/GS, VBS and VBS/GS, respectively, silage DM intakes were 6.5, 7.0, 7.2, 6.1 and 6.6 (s.e.d.0.55) kg/day and live weight gains were 0.94, 0.72, 0.63, 0.65 and 0.73 (s.e.d.0.076) kg/day. Silage type did not affect carcass fatness, the colour or tenderness of meat or the fatty acid composition of the intramuscular fat in thelongissimus dorsimuscle.
Vitamin D status of children in Kerala, southern India
Authors: Vijayakumar Madhava , Bhatia Vijayalakshmi , George Biju 
Published: January 2019

AbstractObjectiveTo study plasma 25-hydroxyvitamin D (25(OH)D) status of children in Kerala, southern India, and its relationship with sociodemographic variables.DesignCross-sectional observational study.SettingTertiary government hospital.ParticipantsChildren (n 296) with trivial acute illness were enrolled. Sun exposure and Ca and vitamin D intakes (7 d dietary recall) were documented. Serum Ca, P, alkaline phosphatase, plasma 25(OH)D and parathyroid hormone (PTH) were measured.ResultsPrevalence of vitamin D deficiency (plasma 25(OH)D <30 nmol/l) was 11·1% (median, interquartile range (IQR): 52·6, 38·4–65·6 nmol/l). Children who ate fish daily had significantly higher plasma 25(OH)D than those who did not (median, IQR: 52·5, 40·8–68·9 v. 49·1, 36·2–60·7 nmol/l; P = 0·02). Those investigated in the months of March–May showed highest 25(OH)D v. those enrolled during other times (median, IQR: 58·7, 45·6–81·4 v. 45·5, 35·6–57·4 nmol/l; P <0·001). Plasma 25(OH)D correlated positively with serum P (r = 0·24, P <0·001) and Ca intake (r = 0·16, P 0·03), negatively with age (r = −0·13, P 0·03) and PTH (r = −0·22, P <0·001.). On linear regression, summer season (March–May), lower age, daily fish intake and higher Ca intake were independently associated with plasma 25(OH)D.ConclusionsPrevalence of vitamin D deficiency is low in Kerala. The natural fish diet of coastal Kerala and the latitude may be protective. Public health policy in India should take account of this geographical diversity.
Logics of stratified identity management in world politics
Authors: Ward Steven 
Published: January 2019

AbstractThe importance of concerns about status in world politics has rarely been as evident as it is today. Yet our understanding of how status dynamics influence politics and foreign policy remains limited. Dominant approaches draw on insights from social psychology about individual attitudes and behavior, but scale these up to build accounts of states as unitary or anthropomorphic actors. This results in serious theoretical problems and analytical blind spots. In this article, I offer a new framework – still rooted in social psychological insights about intergroup status dynamics – that addresses these problems. I recast the fundamental question from one about how states react to status dissatisfaction to one about how individuals – with different psychological profiles, different interests, and different positions within the national community – react to anxiety about the status of the state with they identify. I develop four broad logics that inform responses to national status dissatisfaction: identification change, emulation, transformation, and rejection. These logics subsume familiar arguments about how states seek status, but they also accommodate additional variation and explanatory possibilities. They thus constitute a more flexible framework that is better suited than existing alternatives to understand the full variety of ways in which status dynamics may influence world politics.
Causal role of group B Streptococcus-induced acute chorioamnionitis in intrauterine growth retardation and cerebral palsy-like impairments
Authors: Allard M.-J. , Brochu M.-E. , Bergeron J. D. , Segura M. , Sébire G. 
Published: January 2019

AbstractChorioamnionitis and intrauterine growth retardation (IUGR) are risk factors for cerebral palsy (CP). Common bacteria isolated in chorioamnionitis include group B Streptococcus (GBS) serotypes Ia and III. Little is known about the impact of placental inflammation induced by different bacteria, including different GBS strains. We aimed to test the impact of chorioamnionitis induced by two common GBS serotypes (GBSIa and GBSIII) on growth and neuromotor outcomes in the progeny. Dams were exposed at the end of gestation to either saline, inactivated GBSIa or GBSIII. Inactivated GBS bacteria invaded placentas and triggered a chorioamnionitis featured by massive polymorphonuclear cell infiltrations. Offspring exposed to GBSIII – but not to GBSIa – developed IUGR, persisting beyond adolescent age. Male rats in utero exposed to GBSIII traveled a lower distance in the Open Field test, which was correlating with their level of IUGR. GBSIII-exposed rats presented decreased startle responses to acoustic stimuli beyond adolescent age. GBS-exposed rats displayed a dysmyelinated white matter in the corpus callosum adjacent to thinner primary motor cortices. A decreased density of microglial cells was detected in the mature corpus callosum of GBSIII-exposed males – but not females – which was correlating positively with the primary motor cortex thickness. Altogether, our results demonstrate a causal link between pathogen-induced acute chorioamnionitis and (1) IUGR, (2) serotype- and sex-specific neuromotor impairments and (3) abnormal development of primary motor cortices, dysmyelinated white matter and decreased density of microglial cells.