bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis
Authors: Pedersen Niels C , Perron Michel , Bannasch Michael , Montgomery Elizabeth , Murakami Eisuke , Liepnieks Molly , Liu Hongwei 
Published: February 2019

Objectives The aim of this study was to determine the safety and efficacy of the nucleoside analog GS-441524 for cats suffering from various forms of naturally acquired feline infectious peritonitis (FIP). Methods Cats ranged from 3.4–73 months of age (mean 13.6 months); 26 had effusive or dry-to-effusive FIP and five had non-effusive disease. Cats with severe neurological and ocular FIP were not recruited. The group was started on GS-441524 at a dosage of 2.0 mg/kg SC q24h for at least 12 weeks and increased when indicated to 4.0 mg/kg SC q24h. Results Four of the 31 cats that presented with severe disease died or were euthanized within 2–5 days and a fifth cat after 26 days. The 26 remaining cats completed the planned 12 weeks or more of treatment. Eighteen of these 26 cats remain healthy at the time of publication (OnlineFirst, February 2019) after one round of treatment, while eight others suffered disease relapses within 3–84 days. Six of the relapses were non-neurological and two neurological. Three of the eight relapsing cats were treated again at the same dosage, while five cats had the dosage increased from 2.0 to 4.0 mg/kg q24h. The five cats treated a second time at the higher dosage, including one with neurological disease, responded well and also remain healthy at the time of publication. However, one of the three cats re-treated at the original lower dosage relapsed with neurological disease and was euthanized, while the two remaining cats responded favorably but relapsed a second time. These two cats were successfully treated a third time at the higher dosage, producing 25 long-time survivors. One of the 25 successfully treated cats was subsequently euthanized due to presumably unrelated heart disease, while 24 remain healthy. Conclusions and relevance GS-441524 was shown to be a safe and effective treatment for FIP. The optimum dosage was found to be 4.0 mg/kg SC q24h for at least 12 weeks.
Comparison of aflibercept and ranibizumab in diabetic macular edema associated with subretinal detachment
Authors: Ozkaya Abdullah , Demir Gokhan , Kirmaci Asli 
Published: February 2019

Purpose: To compare the efficacy of ranibizumab and aflibercept in the treatment of diabetic macular edema associated with subfoveal retinal detachment. Methods: This is a retrospective, comparative study. The treatment-naïve diabetic macular edema patients who had diabetic macular edema associated with subfoveal retinal detachment and underwent intravitreal aflibercept or intravitreal ranibizumab treatment were included. The patients were treated on a pro re nata treatment regimen after a loading dose of 3-monthly injections and the follow-up time was 12 months. The primary outcome measure of this study was the presence of subfoveal retinal detachment after treatment at different time points. The secondary outcome measures were the change in best corrected visual acuity and central retinal thickness. Results: A total of 46 eyes of 46 patients were included. The aflibercept group consisted of 20 and the ranibizumab group consisted of 26 eyes. During the follow-up period of 12 months, subfoveal retinal detachment was completely resolved in 75% versus 57.7% of the eyes at month 3 (p = 0.2), 90% versus 76.9% at month 6 (p = 0.2), 90% versus 65.4% at month 9 (p = 0.05), and 100% versus 80.8% at month 12 (p = 0.03) in the intravitreal aflibercept versus intravitreal ranibizumab groups. The change in best corrected visual acuity was not statistically different between the groups at months 3, 6, 9, and 12, respectively (p > 0.05 for all). Conclusion: Both intravitreal aflibercept and intravitreal ranibizumab were effective in regards to anatomical and functional outcomes of diabetic macular edema patients associated with subfoveal retinal detachment. Interestingly, intravitreal aflibercept seemed more effective than intravitreal ranibizumab in the resolution of subfoveal retinal detachment at month 12.
Arts-based interventions for youth with mental health challenges
Authors: Coholic Diana , Schinke Robert , Oghene Odirin , Dano Kelsey , Jago Mary , McAlister Heather , Grynspan Patricia 
Published: February 2019

Summary We facilitated an arts-based mindfulness group program with youths who were receiving short-term in-patient mental health supports within hospital. We aimed to explore the challenges and benefits these marginalized youths experienced through their exposure to the group intervention. Forty pregroup and 24 postgroup interviews were analyzed using a thematic analysis framework. Findings: The qualitative findings are presented using creative nonfiction in the form of a composite vignette. The composite vignette portrays the content within the themes, creatively telling a more compelling story that illustrates key points and themes within the data set. The vignette shows how mental health challenges created problems in the youths’ lives. Although most of the youths were initially nervous about participating in the program, the strengths and arts-based nature of the program helped them to connect with others in the group and express themselves. All of the youths reported that the group program was enjoyable and beneficial. They learned to identify what they were feeling/thinking and to express these feelings/thoughts using creative means of expression. Making art helped them to develop their self-awareness and created enjoyment in the group and with the group methods. Also, learning about mindfulness helped them to think in different ways, and to focus and relax more. Application: The results of this pilot project warrant further investigation into the benefits of creative strengths-based mindfulness-based interventions for in-patient youths experiencing mental health challenges. The composite vignette centers the youths’ voices and provides a comprehensive account of their experiences.
Efficacy of a nurse-led lipid-lowering secondary prevention intervention in patients hospitalized for ischemic heart disease: A pilot randomized controlled trial
Authors: Ruiz-Bustillo Sonia , Ivern Consol , Badosa Neus , Farre Nuria , Marco Esther , Bruguera Jordi , Cladellas Mercè , Enjuanes Cristina , Cainzos-Achirica Miguel , Marti-Almor Julio , Comin-Colet Josep 
Published: February 2019

Background and aims: Lack of achievement of secondary prevention objectives in patients with ischaemic heart disease remains an unmet need in this patient population. We aimed at evaluating the six-month efficacy of an intensive lipid-lowering intervention, coordinated by nurses and implemented after hospital discharge, in patients hospitalized for an ischaemic heart disease event. Methods: Randomized controlled trial, in which a nurse-led intervention including periodic follow-up, serial lipid level controls, and subsequent optimization of lipid-lowering therapy, if appropriate, was compared with standard of care alone in terms of serum lipid-level control at six months after discharge. Results: The nurse-led intervention was associated with an improved management of low-density lipoprotein (LDL) cholesterol levels compared with standard of care alone: LDL cholesterol levels ⩽100 mg/dL were achieved in 97% participants in the intervention arm as compared with 67% in the usual care arm ( p value <0.001), the LDL cholesterol ⩽70 mg/dL target recommended by the 2016 European Society of Cardiology guidelines was achieved in 62% vs. 37% participants ( p value 0.047) and the LDL cholesterol reduction of ⩾50% recommended by the American College of Cardiology/American Heart Association in 2013 was achieved in 25.6% of participants in the intervention arm as compared with 2.6% in the usual care arm ( p value 0.007). The intervention was also associated with improved blood pressure control among individuals with hypertension. Conclusions: Our findings highlight the opportunity that nurse-led, intensive, post-discharge follow-up plans may represent for achieving LDL cholesterol guideline-recommended management objectives in patients with ischaemic heart disease. These findings should be replicated in larger cohorts.
Protest und Streiks in der Schweiz in der zweiten Hälfte des Ersten Weltkriegs
Authors: Degen Bernard , Koller Christian 
Published: February 2019

Zusammenfassung Switzerland was spared direct involvement into the First World War, nevertheless the global conflict had tremendous political and economic impact on the neutral republic. Major antagonisms emerged between the different linguistic groups sympathising with opposing belligerent coalitions as well as between different social strata. Food and fuel shortages and wartime inflation as well as a lack of integration of the labour movement into the political system and its partial shift to the left resulted in a wave of strikes and protest in the second half of the war that continued into the first two post-war years. Its culmination was a national general strike in November 1918 lasting for three days upon the war’s conclusion, and that in bourgeois circles was wrongly considered an attempted revolution. Whilst this is considered the most severe crisis in modern Swiss history, from a transnational perspective, it was no more than a relatively mild variation of the worldwide upheavals going on at the time.
Sexualität und Politik um 1968: Eine transnationale Geschichte?
Authors: Levsen Sonja 
Published: February 2019

Zusammenfassung Recent historiography stresses the ‘fundamentally transnational’ character of ‘1968’. The revolt against traditional sexual mores in this vein appears to be one aspect of a transnational or even global ‘youth revolt’. However, when looking beyond slogans such as ‘Make love, not war’ and the iconic images of Berlin’s ‘Kommune 1’, we discover fundamental differences in the ways in which protest movements dealt with sexuality. While ‘liberating’ sexuality in the early 1960s became a core concern of the German New Left, the respective French and British movements paid the topic only scant attention. The article discusses causes and consequences of these divergent paths. It shows that in 1968, the prominence, strategic use and political concept of sexuality in the protests differed widely – a fact that should prompt us to reconsider accepted assumptions about the ‘transnational’ 1960s.
Secular and longitudinal trends in cardiovascular risk in a general population using a national risk model: The Tromsø Study
Authors: Nilsen Amalie , Hanssen Tove A , Lappegård Knut T , Eggen Anne E , Løchen Maja-Lisa , Njølstad Inger , Wilsgaard Tom , Hopstock Laila 
Published: February 2019

Background Primary prevention guidelines promote the use of risk assessment tools to estimate total cardiovascular risk. We aimed to study trends in cardiovascular risk and contribution of single risk factors, using the newly developed NORRISK 2 risk score, which estimates 10-year risk of fatal and non-fatal cardiovascular events. Design Prospective population-based study. Methods We included women and men aged 45–74 years attending the sixth and seventh survey of the Tromsø Study (Tromsø 6, 2007–2008, n = 7284 and Tromsø 7, 2015–2016, n = 14,858) to study secular trends in NORRISK 2 score. To study longitudinal trends, we followed participants born 1941–1962 attending both surveys ( n = 4534). We calculated NORRISK 2 score and used linear regression models to study the relative contribution (% R2) of each single risk factor to the total score. Results Mean NORRISK 2 score decreased and distribution in risk categories moved from higher to lower risk in both sexes and all age-groups between the first and second surveys ( p < 0.001). In birth cohorts, when age was set to baseline in NORRISK 2 calculations, risk score decreased during follow-up. Main contributors to NORRISK 2 were systolic blood pressure, smoking and total cholesterol, with some sex, age and birth cohort differences. Conclusion We found significant favourable secular and longitudinal trends in total cardiovascular risk and single risk factors during the last decade. Change in systolic blood pressure, smoking and cholesterol were the main contributors to risk score change; however, the impact of single risk factors on the total score differed by sex, age and birth cohort.
The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination
Authors: Donaghy Ryan , Han Xu , Rozenova Krasimira , Lv Kaosheng , Jiang Qinqin , Doepner Miriam , Greenberg Roger A. , Tong Wei 
Published: February 2019

Abstract
Hematopoietic stem cell (HSC) homeostasis is controlled by cytokine receptor–mediated Janus kinase 2 (JAK2) signaling. We previously found that JAK2 is promptly ubiquitinated upon cytokine stimulation. Whether a competing JAK2 deubiquitination activity exists is unknown. LNK is an essential adaptor protein that constrains HSC expansion through dampening thrombopoietin (TPO)–induced JAK2 signaling. We show here that a LNK-associated lysine-63 (K63)–deubiquitinating enzyme complex, Brcc36 isopeptidase complex (BRISC), attenuates HSC expansion through control of JAK2 signaling. We pinpoint a direct interaction between the LNK SH2 domain and a phosphorylated tyrosine residue in KIAA0157 (Abraxas2), a unique and defining BRISC component. Kiaa0157 deficiency in mice led to an expansion of phenotypic and functional HSCs. Endogenous JAK2 and phospho-JAK2 were rapidly K63-ubiquitinated upon TPO stimulation, and this action was augmented in cells depleted of the BRISC core components KIAA0157, MERIT40, or BRCC36. This increase in JAK2 ubiquitination after BRISC knockdown was associated with increased TPO-mediated JAK2 activation and protein levels, and increased MPL receptor presence at the cell surface. In addition, BRISC depletion promoted membrane proximal association between the MPL receptor and pJAK2/JAK2, thus enhancing activated JAK2/MPL at the cell membrane. These findings define a novel pathway by which K63-ubiquitination promotes JAK2 stability and activation in a proteasome-independent manner. Moreover, mutations in BRCC36 are found in clonal hematopoiesis in humans. This research may shed light on the mechanistic understanding of a potential role of BRCC36 in human HSCs.
Pracinostat plus azacitidine in older patients with newly diagnosed acute myeloid leukemia: results of a phase 2 study
Authors: Garcia-Manero Guillermo , Abaza Yasmin , Takahashi Koichi , Medeiros Bruno C. , Arellano Martha , Khaled Samer K. , Patnaik Mrinal , Odenike Olatoyosi , Sayar Hamid , Tummala Mohan , Patel Prapti , Maness-Harris Lori , Stuart Robert , Traer Elie , Karamlou Kasra , Yacoub Abdulraheem , Ghalie Richard , Giorgino Ruben , Atallah Ehab 
Published: February 2019

Abstract
Pracinostat, a potent oral pan-histone deacetylase inhibitor with modest single-agent activity in acute myeloid leukemia (AML), has shown synergistic antitumor activity when combined with azacitidine. This single-group, multicenter phase 2 study assessed the safety and efficacy of pracinostat combined with azacitidine in patients who were at least 65 years old with newly diagnosed AML and who were ineligible for standard induction chemotherapy. Patients received pracinostat 60 mg/d, 3 d/wk, for 3 consecutive weeks, plus azacitidine 75 mg/m2 daily for 7 days in a 28-day cycle. Primary endpoints were complete remission (CR), CR with incomplete count recovery (CRi), and morphologic leukemia-free state (MLFS) rates of the combination. Secondary endpoints included safety, progression-free survival (PFS), and overall survival (OS) of the regimen. Fifty patients (33 de novo, 12 secondary, and 5 therapy-related AML) were enrolled. Twenty-six patients (52%) achieved the primary endpoint of CR (42%), CRi (4%), and MLFS (6%). Median OS and PFS were 19.1 months (95% confidence interval [CI], 10-26.5 months) and 12.6 months (95% CI, 10-17.7 months), respectively, with a 1-year OS rate of 62%. Forty-three patients (86%) experienced at least 1 grade 3 or worse treatment-emergent adverse event with the combination, with infections (52%), thrombocytopenia (46%), and febrile neutropenia (44%) reported as the most common toxicities. The 30- and 60-day all-cause mortality rates were 2% and 10%, respectively. DNA sequencing revealed somatic mutations at baseline, and clearance rates correlated with response to treatment. Pracinostat plus azacitidine is a well-tolerated and active regimen in the frontline treatment of older patients with AML unfit for intensive therapy. A larger controlled trial is ongoing. This trial was registered at www.clinicaltrials.gov as #NCT01912274.
Transitions between informal and formal employment: results from a worker survey in Bangladesh
Authors: Gutierrez Italo A. , Kumar Krishna B. , Mahmud Minhaj , Munshi Farzana , Nataraj Shanthi 
Published: February 2019

Abstract
We study transitions between different types of formal and informal employment using retrospective job histories from a new survey in Bangladesh. Workers transitioning between jobs are most likely to remain in the same type of employment, although there is still substantial churn across employment types. Private wage employees have higher probability of transitioning to a new job, and changes in earnings and benefits suggest evidence of upward mobility. Nevertheless, there is also non-trivial risk of downward mobility, especially for those transitioning into casual employment, which has the lowest level of earnings and benefits and the highest levels of exposure to workplace hazards and violence. Overall, the informal sector appears to include subpopulations consistent with both the traditional view that it is a segmented portion of the labor market with few prospects of upward mobility, and with the alternative view that it is a dynamic, entrepreneurial alternative to wage employment.
Borneo herbal plant extracts as a natural medication for prophylaxis and treatment of Aeromonas hydrophila and Pseudomonas fluorescens infection in tilapia (Oreochromis niloticus)
Authors: Hardi Esti Handayani , Nugroho Rudy Agung , Kusuma Irawan Wijaya , Suwinarti Wiwin , Sudaryono Agung , Rostika Rita 
Published: February 2019

Background: The combination of some plant extracts to prevent and treat bacterial infections is gaining momentum, because of effectiveness against certain bacteria. This study aims to describe the antibacterial and immunostimulant abilities of Boesenbergia pandurata (BP), Solanum ferox (SF) and Zingiber Zerumbet (ZZ) plant extracts to treat and prevent Aeromonas hydrophila and Pseudomonas fluorescens infection on Tilapia (Oreochromis niloticus). Methods: Tilapia (initial weight 15±2 g) were injected intramuscularly (0.1 ml/fish) with a combination of A. hydrophila and P. fluorescens at a density of 1×10 5 CFU ml -1 of each bacteria. Treatment trials were performed at day 7 post-injection with each combined extract, while the prevention trial was performed by including the combined extract into the commercial diet for six and seven days prior to injection. Various extract combinations were 60 mg SF extract/kg feed with 40 mg ZZ/kg feed (SF60/ZZ40), SF50/ZZ50, BP90/SF10, and BP50/SF50. Haemato-immunological parameters were performed for four weeks. Results: In prevention trials, tilapia fed SF50/ZZ50 showed a significant increase of white and red blood cells. Similarly, significantly increased haematocrit was found in tilapia fed SF50/ZZ50 in the treatment trial but not in the prevention trial. In both trials, haemoglobin of tilapia was not affected by any combined extracts but decreased the number of bacteria. Phagocytic index, respiratory burst, lysozyme activity and survival rate of fish fed combined extracts were found significantly higher than controls. The amount of pathogenic bacteria in fish fed combined extracts was lower than the control at week 4 (P<0.05). In both trials The percentage of survival rate and relative percent survival of tilapia fed SF 50/ZZ 50, showed the optimum results compared to the other combinations. Conclusions: The combined extract in feed, especially SF50/ZZ50 has a positive effect on the tilapia's innate immune system of tilapia to treat and prevent bacterial infections.
Correlation of cervical progesterone levels to plasma progesterone levels in normal pregnancy and preterm labor: A cross-sectional study
Authors: Lisnawati Yuyun , Wibowo Noroyono , Mariana Ana 
Published: February 2019

Background: Theory of “functional progesterone withdrawal” explains the role of progesterone prior to delivery. Previous studies mentioned the existence of progesterone regulation in the cervix that plays a role in maintaining the integrity of the cervix and cervical ripening. Cervical progesterone levels relate to activities of progesterone at the cervix, compared to its amount in circulation. The objective of this study was to measure cervical mucus progesterone levels and its correlation to plasma progesterone levels in pregnancy. Methods: This was a cross sectional study conducted in January-September 2010 at Persahabatan Hospital. The subjects were pregnant woman in the 28th – 34th weeks of gestational age. In total, 72 subjects who met the criteria were divided into normal pregnancy group and preterm labor group. The cervical and plasma progesterone levels were measured using The Advia Centaur® Progesterone kit, which is a commercial immunoassay with direct chemiluminescence method. Results: There was positive correlation (r=0.539) between cervical progesterone levels with plasma progesterone levels in the preterm labor group. There was no correlation between cervical progesterone levels with plasma progesterone levels in the normal pregnancy group. Conclusion: This study showed that cervical progesterone levels could be measured through cervical mucus. A significant positive correlation was found by this study between cervical progesterone levels and plasma progesterone levels in the preterm labor group. This study is expected to provide new insights for understanding the metabolism and the role of progesterone in maintaining cervical integrity during pregnancy, and its relation to prevention of preterm birth.
La gobernanza ambiental: el estudio del capital social en las Áreas Naturales Protegidas
Authors: Cruz Coria Erika , Zizumbo Villarreal Lilia , Chaisatit Nuchnudee Chaisatit 
Published: February 2019

Si bien, el Decreto de Áreas Naturales Protegidas (anp) en la mayoría de los países de Centroamérica y el Caribe se ha dado en diferentes momentos históricos, esta figura jurídica ha surgido básicamente como un instrumento de conservación propuesta por la política de Estado; por tanto, las áreas se encuentran administradas por diversos organismos gubernamentales que a todas luces limitan la participación de otros actores sociales y el aprovechamiento sustentable de los recursos en estos territorios. Las anp en México no son la excepción, estas se encuentran bajo un esquema de gobernabilidad que se caracteriza porque el Estado se erige como el actor central, el cual se encarga de normar tanto el acceso como el aprovechamiento de esos ecosistemas que también son objeto de interés por parte de múltiples actores sociales. En este contexto, el objetivo es proponer algunas herramientas teórico-metodológicas para la comprensión de la estructura de las relaciones sociales en las anp mexicanas, lo cual, se supone, es fundamento para el diseño de intervenciones planificadas encaminadas al desarrollo de formas de gobernanza ambiental. Para ello, se retomó la perspectiva teórica del capital social (cs) con énfasis en el cs estructural, por su capacidad explicativa en relación con los vínculos de naturaleza horizontal y vertical, pero, sobre todo, es una herramienta que permite la comprensión de la gobernanza ambiental como un proceso socio-organizativo de carácter multiactoral.