bluuebunny/crossref_metadata_2025_split huggingface dataset:
“L'Aimable Visir”
Authors: Cascavilla Giuseppe Pio 
Published: September 2018

AbstractThis article focuses on the experience of Pierre David, Napoleonic consul in Bosnia from 1807 to 1814, under Hüsrev Mehemed Pasha's tenure as governor of the province (1806–8). It relies on the diplomatic correspondence between David and the Ministry of Foreign Affairs. The goal is to highlight the French interests in the area and their modification after the Treaty of Tilsit; the figure of Hüsrev Mehemed Pasha; the relationship of the locals with the Ottoman authority and the Consul; and the local effects of the revolution that overthrew the reformer sultan Selim III. The article reveals the ineffectiveness of communication from the highest to the lowest levels of French diplomacy in the Levant. It also demonstrates the complex Ottoman center-periphery dynamics during one of the empire's most critical moments.Cet article se focalise sur l'expérience de Pierre David, consul napoléonien en Bosnie de 1807 à 1814, pendant le mandat de Hüsrev Mehemed Pacha comme gouverneur de la province (1806–8). Par le biais de la correspondance diplomatique entre David et le ministère des Affaires étrangères, nous mettons en évidence les intérêts de la France dans la région balkanique et leur modification après le Traité de Tilsit, ainsi que la figure de Hüsrev Mehemed Pacha ; les relations entre la population locale, les autorités centrales ottomanes et le consul ; et, finalement, les effets locaux de la révolution qui a renversé le sultan réformateur Selim III. Nos résultats montrent un manque de communication entre les différents niveaux de la diplomatie française dans le Levant et une difficulté dans la redéfinition des priorités à l'échelle locale. L'article démontre aussi la complexité des dynamiques centre-périphérie pendant l'un des moments les plus difficiles de l'empire ottoman.
“The Christmas Tree of the Alsatians and Lorrainers”
Authors: Foley Susan 
Published: September 2018

AbstractThis article underlines the significance of emotions in shaping political culture by analyzing a largely forgotten spectacle, the “Christmas Tree of the Alsatians and Lorrainers.” Held annually in Paris from 1872 until 1918, the event aided children whose families had fled Alsace and Lorraine to retain French citizenship following France's defeat in the Franco-Prussian War. It also provided an afternoon's entertainment for a paying audience. The Christmas tree was strongly associated with Alsace, and the event was a spectacle of patriotism, widely reported in the popular press. Through music, verse, and performance, those present mourned “the Lost Provinces” and celebrated the patrie, mobilizing for the Republic the emotions roused by the loss of Alsace and Lorraine. This event highlights the significance of popular cultural practices in developing the “sympathetic emotional regime” that underpinned the successful implantation of the Third Republic.Cet article analyse un spectacle tombé dans l'oubli, « L'arbre de Noël des Alsaciens-Lorrains », démontrant l'importance de l'émotion en forgeant une culture politique. Cet événement, très couru et largement diffusé dans la presse populaire, se déroulait à Paris chaque Noël de 1872 à 1918. Il aidait les enfants dont les familles, ayant choisi la citoyenneté française, avaient dû quitter l'Alsace et la Lorraine après la guerre de 1870. A travers la musique, la poésie, et l'interprétation dramatique, le spectacle pleurait « les provinces perdues » et les insérait au cœur de la patrie imaginaire française. L'événement, organisé par l'élite républicaine expatriée de l'Alsace et de la Lorraine, constituait une performance collective de l'émotion intense ainsi créée. « L'arbre de Noël des Alsaciens-Lorrains » était un des premiers parmi un large répertoire d'événements culturels de l'époque qui soutenaient la cause républicaine en nourrissant un régime émotionnel favorable.
The spatial and temporal dynamics of nuclear RNAi-targeted retrotransposon transcripts in Caenorhabditis elegans
Authors: Ni Julie Zhouli , Kalinava Natallia , Mendoza Sofia Galindo , Gu Sam Guoping 
Published: September 2018

ABSTRACT
Nuclear RNA interference provides a unique approach to the study of RNA-mediated transgenerational epigenetic inheritance. A paradox in the field is that expression of target loci is necessary for the initiation and maintenance of their silencing. How expression and repression are coordinated during animal development is poorly understood. To resolve this gap, we took imaging, deep-sequencing and genetic approaches towards delineating the developmental regulation and subcellular localization of RNA transcripts of two representative endogenous targets, the LTR retrotransposons Cer3 and Cer8. By examining wild-type worms and a collection of mutant strains, we found that the expression and silencing cycle of Cer3 and Cer8 is coupled with embryonic and germline development. Strikingly, endogenous targets exhibit a hallmark of nuclear enrichment of their RNA transcripts. In addition, germline and somatic repressions of Cer3 have different genetic requirements for three heterochromatin enzymes, MET-2, SET-25 and SET-32, in conjunction with the nuclear Argonaute protein HRDE-1. These results provide the first comprehensive cellular and developmental characterization of nuclear RNAi activities throughout the animal reproductive cycle.
S-acylation regulates the trafficking and stability of the unconventional Q-SNARE STX19
Authors: Ampah Khamal K. , Greaves Jennifer , Shun-Shion Amber S. , Asnawi Asral W. , Lidster Jessica A. , Chamberlain Luke H. , Collins Mark O. , Peden Andrew A. 
Published: September 2018

ABSTRACT
STX19 is an unusual Qa-SNARE as it lacks a C-terminal transmembrane domain. However, it is efficiently targeted to post-Golgi membranes. Here, we set out to determine the intracellular localisation of endogenous STX19 and elucidate the mechanism by which it is targeted to membranes. We have found that a pool of STX19 is localised to tubular recycling endosomes where it colocalises with MICAL-L1 and Rab8 (which has Rab8a and Rab8b forms). Using a combination of genetic, biochemical and cell-based approaches, we have identified that STX19 is S-acylated at its C-terminus and is a substrate for several Golgi-localised S-acyltransferases, suggesting that STX19 is initially S-acylated at the Golgi before trafficking to the plasma membrane and endosomes. Surprisingly, we have found that S-acylation is a key determinant in targeting STX19 to tubular recycling endosomes, suggesting that S-acylation may play a general role in directing proteins to this compartment. In addition, S-acylation also protects STX19 from proteosomal degradation, indicating that S-acylation regulates the function of STX19 at multiple levels.
This article has an associated First Person interview with the first author of the paper.
From Ionic Liquids to Solvate Ionic Liquids: Challenges and Opportunities for Next Generation Battery Electrolytes
Authors: Watanabe Masayoshi , Dokko Kaoru , Ueno Kazuhide , Thomas Morgan L 
Published: September 2018

Abstract
Certain concentrated mixtures of lithium salt and solvent (ligand) are no longer simple solutions, but categorized as solvate ionic liquids (SILs), where the solvent strongly coordinates to the cation to form a solvate, a negligible amount of free solvent remains, and thus the SIL consists of the solvate cation and the anion. Typical examples are mixtures of lithium bis(trifluoromethane sulfonyl)amide (Li[TFSA]) and certain glymes The successful formation of a SIL greatly depends on both the ligand and lithium salt structures. To obtain robust and long-lived solvates, a ligand exhibiting a chelate effect is essential and n = 3 and 4 (i.e. triglyme and tetraglyme) are suitable for the formation of lithium solvates. The Lewis basicity of the lithium salt anion also significantly affects the formation of SILs. Specifically, a weak Lewis basicity promotes the formation of a SIL, since the ligand-Li+ interaction overwhelms the Li+-anion interaction. SILs can be diluted with rather low polarity solvents to increase the ionic conductivity, where the solvate structure is maintained even after the dilution. SILs exhibit unique features as electrolytes, including the enhancement of oxidation stability of the component glymes, unique Li+ transport through ligand exchange when interfacial electrochemical reactions are occurring, the inhibition of aluminum corrosion when Al foil is used as a cathode current collector, poorly-solubilizing towards ionic electroactive materials, and electrochemical graphite intercalation reactions. These features greatly enhance the possibility for application of SILs as next generation lithium battery electrolytes. Furthermore, new polymer electrolytes containing SILs have been proposed, simultaneously enabling film-processability, high ionic conductivity, thermal stability, and a wide potential window. Preservation of the solvate structure in the polymeric phases is pivotal to such achievements.
Design and implementation of semester long project and problem based bioinformatics course
Authors: Saarunya Geetha , Ely Bert 
Published: September 2018

Background: Advancements in ‘high-throughput technologies’ have inundated us with data across disciplines. As a result, there is a bottleneck in addressing the demand for analyzing data and training of ‘next generation data scientists’. Methods: In response to this need, the authors designed a single semester “Bioinformatics” course that introduced a small cohort of students at the University of South Carolina to methods for analyzing data generated through different ‘omic’ platforms using variety of model systems. The course was divided into seven modules with each module ending with a problem. Results: Towards the end of the course, the students each designed a project that allowed them to pursue their individual interests. These completed projects were presented as talks and posters at ISCB-RSG-SEUSA symposium held at University of South Carolina. Conclusions: An important outcome of this course design was that the students acquired the basic skills to critically evaluate the reporting and interpretation of data of a problem or a project during the symposium.
FUT2 secretor genotype and susceptibility to infections and chronic conditions in the ALSPAC cohort
Authors: Azad Meghan B. , Wade Kaitlin H. , Timpson Nicholas J. 
Published: September 2018

Background:TheFUT2(fucosyltransferase-2) gene determines blood group secretor status. Being homozygous for the inactive “non-secretor” rs601338(A) allele confers resistance to certain infections (e.g.Norovirus,Rotavirus) and susceptibility to others (e.g.Haemophilus influenza,Streptococcus pneumonia). Non-secretors also have an increased risk of type 1 diabetes and inflammatory bowel disease. We examinedFUT2genotype, infections and chronic conditions in a population-based cohort.Methods:We studied 7,582 pregnant women from the ALSPAC pregnancy cohort. Infections (measles, mumps, chicken pox, whooping cough, meningitis, herpes, gonorrhea and urinary infections) and chronic conditions (kidney disease, hypertension, diabetes, rheumatism, arthritis, psoriasis, hay fever, asthma, eczema and allergies) were self-reported.FUT2secretor status was determined from the rs601338 genotype. ABO blood type was obtained from clinical records.Results:Overall, 1920 women (25.3%) were homozygous for the non-secretor allele (AA). Secretor status was associated with mumps, with 68% of non-secretors experiencing this infection, compared to 48% of secretors (RR, 1.40; 95% CI, 1.34–1.46). A weaker association was observed for measles infection (76% vs. 72%; RR, 1.05; 95% CI, 1.02–1.09). Non-secretors also experienced an increased risk of kidney disease (5.4% vs. 3.9%; RR, 1.39; 95% CI, 1.11–1.75). Independent of secretor status, AB blood type was a risk factor for mumps (RR 1.15; 95%CI, 1.03, 1.28 compared to type O). We found no evidence of interaction between secretor status and blood type. For some conditions, including asthma and arthritis,FUT2heterozygosity (GA) appeared to confer an intermediate phenotype. There was no strong evidence of association between secretor status and other infections or chronic conditions, although statistical power was limited for rare outcomes.Conclusion:Our results identify an association betweenFUT2secretor status and self-reported kidney disease, and confirm a recently reported association with susceptibility to mumps infection. The clinical implications of these associations warrant further investigation.
ИНТЕНСИФИКАЦИЯ ПРОЦЕССА ОБУЧЕНИЯ ПРОФЕССИОНАЛЬНО ОРИЕНТИРОВАННЫМ ИНОЯЗЫЧНЫМ КОММУНИКАТИВНЫМ НАВЫКАМ СРЕДСТВАМИ ОНЛАЙН ТЕХНОЛОГИЙ
Authors: Nevolina Ksenia Viktorovna , Podkamennaya Elizaveta Vasilievna , Fetisova Svetlana Anatolievna 
Published: September 2018

Цель данной работы заключается в систематизации теоретических и практических аспектов проблемы внедрения онлайн технологий в процесс обучения профессионально-ориентированным иноязычным коммуникативным навыкам студентов неязыковых вузов.Материалы и методы исследования. Применяемый метод анализа и обобщения, а также логический метод позволяют суммировать теоретические наработки в области инновационных направлений преподавания иностранных языков. Базой для практической части исследования являются метод наблюдения и метод эксперимента.Результаты исследования. Анализ научных работ, посвященных проблеме использования интерактивных форм обучения, послужили отправной точкой для авторской разработки процедуры обучения организации и проведения вебинаров на английском языке, эффективность которой была доказана экспериментальным путем.Обсуждение и заключения. Практическая значимость статьи заключается в универсальном характере алгоритма применения вебинара как интерактивной образовательной технологии. Вебинар рассматривается как интерактивная форма, организуемая и проводимая самими студентами для совершенствования навыков их профессионального общения. Результаты проведенного исследования могут быть полезны и интересны как специалистам в области высшего образования и студентам, а также послужить материалом для дальнейшего совершенствования инновационных форм интерактивного обучения.
Mental rotation task in bipolar disorder
Authors: Chrobak Adrian , Jeziorko Szymon , Tereszko Anna , Janeczko Weronika , Arciszewska Aleksandra , Siuda-Krzywicka Katarzyna , Starowicz-Filip Anna , Siwek Marcin , Dudek Dominika 
Published: September 2018

Cel pracyChoroba Afektywna Dwubiegunowa (ChAD) istotnie wpływa na poziom dysfunkcji poznawczych i motorycznych. Badania nad funkcjami poznawczymi w Chorobie Afektywnej Dwubiegunowej wskazują między innymi na występowanie deficytów w zakresie przetwarzania wzrokowo – przestrzennego i pamięci wzrokowo – przestrzennej. Dotychczas w badaniach z udziałem pacjentów z ChAD nie wykorzystywano jednak Testu Rotacji Mentalnych (Mental Rotation Task) do oceny tych funkcji. Naszym celem było wprowadzenie tej metody i ocena wspomnianych zaburzeń w grupie pacjentów z ChAD w eutymii.MetodaW badaniu wzięło udział 31 pacjentów z ChAD w fazie eutymii oraz 27 zdrowych ochotników dobranych pod względem wieku i lat edukacji. Każdy z uczestników wykonywał komputerową wersję Testu Rotacji Mentalnych. Badani mieli za zadanie porównywać dwie zrotowane względem siebie figury i ocenić ich podobieństwo, wskazując czy figury są identyczne, czy też stanowią swoje lustrzane odbicie.WynikiTest wykazał istotnie dłuższy czas reakcji w grupie pacjentów z ChAD w warunkach zrotowania figur pod kątem -90, -45, 45, 90 stopni oraz w przypadku braku rotacji. Dla kątów -135, 135 i 180 stopni nie odnotowano istotnej różnicy między grupami. Poziom poprawności wykonania był istotnie niższy w grupie pacjentów niż w grupie kontrolnej zarówno w wyniku ogólnym jak i w poszczególnych warunkach zadania. Korelacja między średnim czasem reakcji a poprawnością okazała się nieistotna.WnioskiNasze wyniki są zgodne z literaturą opisującą deficyty wzrokowo-przestrzenne w ChAD. Badanie to jako pierwsze prezentuje deficyty rotacji umysłowych u pacjentów z ChAD w fazie eutymii.
Predictors of Clinically Significant Echocardiography Findings in Older Adults with Syncope: A Secondary Analysis
Authors: Probst Marc A. , Gibson Thomas A. , Weiss Robert E. , Yagapen Annick N. , Malveau Susan E. , Adler David H. , Bastani Aveh , Baugh Christopher W. , Caterino Jeffrey M. , Clark Carol L. , Diercks Deborah B. , Hollander Judd E. , Nicks Bret A. , Nishijima Daniel K. , Shah Manish N. , Stiffler Kirk A. , Storrow Alan B. , Wilber Scott T. , Sun Benjamin C. 
Published: September 2018

BACKGROUNDSyncope is a common reason for visiting the emergency department (ED) and is associated with significant healthcare resource utilization.OBJECTIVETo develop a risk‐stratification tool for clinically significant findings on echocardiography among older adults presenting to the ED with syncope or nearsyncope.DESIGNProspective, observational cohort study from April 2013 to September 2016SETTINGEleven EDs in the United StatesPATIENTSWe enrolled adults (≥60 years) who presented to the ED with syncope or near‐syncope who underwent transthoracic echocardiography (TTE).MEASUREMENTSThe primary outcome was a clinically significant finding on TTE. Clinical, electrocardiogram, and laboratory variables were also collected. Multivariable logistic regression analysis was used to identify predictors of significant findings on echocardiography.RESULTSA total of 3,686 patients were enrolled. Of these, 995 (27%) received echocardiography, and 215 (22%) had a significant finding on echocardiography. Regression analysis identified five predictors of significant findings: (1) history of congestive heart failure, (2) history of coronary artery disease, (3) abnormal electrocardiogram, (4) high‐sensitivity troponin‐T >14 pg/mL, and 5) N‐terminal pro B‐type natriuretic peptide >125 pg/mL. These five variables make up the ROMEO (Risk Of Major Echocardiography findings in Older adults with syncope) criteria. The sensitivity of a ROMEO score of zero for excluding significant findings on echocardiography was 99.5% (95% CI: 97.4%‐99.9%) with a specificity of 15.4% (95% CI: 13.0%‐18.1%).CONCLUSIONSIf validated, this risk‐stratification tool could help clinicians determine which syncope patients are at very low risk of having clinically significant findings on echocardiography.FUNDINGThis project was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Number R01 HL111033. Dr. Probst is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Number K23HL132052‐02.
Risk Averse Shortest Paths: A Computational Study
Authors: Chicoisne Renaud , Ordóñez Fernando , Espinoza Daniel 
Published: September 2018

In this work we consider the shortest path problem with uncertainty in arc lengths and convex risk measure objective. We explore efficient implementations of sample average approximation (SAA) methods to solve shortest path problems when the conditional value at risk and entropic risk measures are used and there is correlation present in the uncertain arc lengths. Our work explores the use of different decomposition techniques to achieve an efficient implementation of SAA methods for these nonlinear convex integer optimization problems. A computational study shows the effect of geometry, uncertainty correlation and variance, and risk measure parameters on efficiency and accuracy of the methods developed.Data and the online supplement are available at https://doi.org/10.1287/ijoc.2017.0795 .
Macau wine festivalscape: Attendees’ satisfaction and behavioural intentions
Authors: Choe Jaeyeon , Qian Xinyi , O’ Regan Michael , Yap Matthew H. T. 
Published: September 2018

Abstract
This article explores festivalscape factors at an international wine and dine festival in Macau, a Special Administrative Region (SAR) of the People’s Republic of China. The main goal of this study is to assess satisfaction with various festivalscape factors and identify the relations between the festivalscape construct and behavioural intention. The article also explores whether festivalscape factors are influenced by attendee attributes. The study found that festivalscape scores had significant positive effects on perceived value for money, overall satisfaction and intention to revisit. Perceived value for money and overall satisfaction had significantly positive effect on intention to revisit and becoming a repeat visitor. The findings provide valuable insights into the festivalscape factors that influence repeat visitation to an emergent cultural-type event in greater China. We also present recommendations for the growth of the city wine and dine festival, so as to help promote and diversify Macau as a world tourism and leisure centre.
The hospitality model revisited: Developing a hospitality model for today and tomorrow
Authors: Lombarts Angelique 
Published: September 2018

Abstract
The main purpose of this research note is to propose a revised version of Reuland, Choudry and Fagel’s hospitality model; the original model took into account the tangible elements such as product and environment and the intangible elements such as behaviour (from both the managerial and the customer’s perspective). The transaction was the actual interaction. The renewed and broadened interest in hospitality demands an updated and broadly applicable hospitality model. To adapt the hospitality model, the concept of hospitality was studied, along with contemporary societal developments of sustainable development (SD) and stakeholder relation management (SRM). The adaptation should meet the needs of present generations without compromising those of future generations. The complexity of today’s networked world was also taken into account. This resulted in a revised model that builds on four sustainability pillars: economical, ecological, social and cultural. It proposes considering hospitality as an experience in which a myriad of stakeholders may interact, involving a variety of products and taking place in various contexts. The main limitation of this note is that this conceptual elaboration has yet to be proven in practice. Therefore, the note ends with suggestions for further research into the applicability of the model in other fields such as healthcare and city management.