bluuebunny/crossref_metadata_2025_split huggingface dataset:
US conservative advocacy organizations and right-wing legal mobilization in Europe
Authors: Southworth Ann 
Published: November 2024

AbstractSome recent work on populist conservative forces engaged in legal mobilization in Europe highlights the involvement of US-based conservative legal advocacy organizations and their European affiliates. These groups are linked to efforts to resist the integration of Europe and the power of the European courts to implement the projects of liberal, left-leaning pro-EU social forces. Little attention thus far has focused on the lawyers active in these advocacy groups, their ties to the American conservative legal movement and the transnational lawyer networks of which they are a part. This essay sketches an agenda for future research on the composition, operations, strategies and discourse of this complex constellation of conservative lawyers and their organizations.
Trends in Twin Births and Survival in Rural Spain: Evidence from 18th to 20th Century
Authors: Marco-Gracia Francisco J. 
Published: November 2024

AbstractThis study examines the changes over time of the twinning rate and infant and child mortality across 17 rural villages in the province of Zaragoza (Spain) over a span of 200 years. The aim is to understand how the twinning rate evolved in conjunction with the processes of economic and social modernization, as well as the demographic transition. During the period analyzed, the twinning rate increased by 10%, rising from 1.26 per 1000 births in the second half of the 18th century to 1.38 per 1000 births in the first half of the 20th century. This rate varied due to hereditary issues, biological factors such as the mother’s age and parity, and socioeconomic features like family occupation and the mother’s education level. In terms of child mortality, twins historically faced a significantly higher mortality rate. However, they benefited greatly from the mortality transition, at least in absolute numbers. While nearly 60% of twins did not survive beyond 5 years of age in earlier periods, the mortality rate for twins decreased to 40% by the first half of the 20th century. The excess mortality was particularly severe for girls, driven by a widespread preference for sons, which led to higher mortality rates for girls in the first 5 years of life, especially in the earliest months. These findings help us understand the improvements in uterine and childhood survival rates for contemporary twins, which can be attributed to the socioeconomic and medical advancements of the 20th century.
Peripartum allopregnanolone blood concentrations and depressive symptoms: a systematic review and individual participant data meta-analysis
Authors: Schoretsanitis Georgios , Osborne Lauren M. , Sundström-Poromaa Inger , Wenzel Elizabeth S. , Payne Jennifer L. , Barbui Corrado , Gastaldon Chiara , Deligiannidis Kristina M. 
Published: November 2024

Abstract
Neuroactive steroids including allopregnanolone are implicated in the pathophysiology of peripartum depressive symptoms (PDS). We performed a systematic review searching PubMed/Embase/PsychInfo/Cinhail through 08/2023 (updated in 07/2024), and conducted a random-effects meta-analysis of studies comparing allopregnanolone blood concentrations in women with versus without PDS at various timepoints during the 2nd and 3rd trimester and the postpartum period, calculating standardized mean differences (SMDs) and 95% confidence intervals (CIs). Meta-regression and subgroup analyses included age, diagnoses of affective disorders before pregnancy, antidepressant treatment, analytical methods, and sample type. Study quality was assessed using the Newcastle-Ottawa-scale. The study protocol was registered on PROSPERO (registration number CRD42022354495). We retrieved 13 studies with 2509 women (n = 849 with PDS). Allopregnanolone concentrations did not differ between women with versus without PDS at any timepoint (p > 0.05). Allopregnanolone concentrations assessed during pregnancy did not differ for women with versus without PDS at postpartum follow-up (p > 0.05). Subgroup analyses indicated higher allopregnanolone concentrations in women with versus without PDS at gestational weeks 21–24 and 25–28 (SMD = 1.07, 95% CI = 0.04, 2.11 and SMD = 0.92, 95% CI = 0.26, 1.59 respectively). Moreover, we reported differences between studies using mass-spectrometry combined with chromatography versus immunoassays at gestational weeks 25–28 (p = 0.01) and plasma versus serum samples at gestational weeks 21–24 (p = 0.005). Study quality was rated as poor, good, and fair for two, one and ten studies respectively. PDS were not associated with differences for allopregnanolone concentrations. The use of heterogenous peripartum time points, study cohorts, depression symptom measures and analytical methods has hampered progress in elucidating neuroactive steroid signaling linked to PDS.
Projection-specific circuits of retrosplenial cortex with differential contributions to spatial cognition
Authors: Lin Xiaoxiao , Ghafuri Ali , Chen Xiaojun , Kazmi Musab , Nitz Douglas A. , Xu Xiangmin 
Published: November 2024

AbstractRetrosplenial cortex (RSC) is a brain region involved in neuropsychiatric and neurodegenerative disorders. It has reciprocal connections with a diverse set of cortical and subcortical brain regions, but the afferent structure and behavioral function of circuits defined by its projection-specific sub-populations have yet to be determined. The corticocortical connections between RSC and secondary motor cortex (M2), as well as corticothalamic connections between RSC and anterodorsal thalamus (AD) have been hypothesized to function as semi-independent, but parallel pathways that impact spatial information processing in distinct ways. We used retrograde and anterograde viral tracers and monosynaptic retrograde rabies virus to quantitatively characterize and compare the afferent and efferent distributions of retrosplenial neuron sub-populations projecting to M2 and AD. AD-projecting and M2-projecting RSC neurons overlap in their collateral projections to other brain regions, but not in their projections to M2 and AD, respectively. Compared with AD-projecting RSC neurons, M2-projecting RSC neurons received much greater afferent input from the dorsal subiculum, AD, lateral dorsal and lateral posterior thalamus, and somatosensory cortex. AD-projecting RSC neurons received greater input from the anterior cingulate cortex and medial septum. We performed chemogenetic inhibition of M2- and AD-projecting RSC neurons and examined its impact on object-location memory, object-recognition, open-field exploration, and place-action association. Our findings indicate that inhibition of M2-projecting RSC neurons impairs object location memory as well as place-action association, while the RSC to AD pathway impacts only object-location memory. The findings indicate that RSC is composed of semi-independent circuits distinguishable by their afferent/efferent distributions and differing in the cognitive functions to which they contribute.
Comparison of BiliCocoon phototherapy with overhead phototherapy in hyperbilirubinemic neonates. A randomized clinical trial
Authors: Donneborg Mette L. , Vandborg Pernille K. , Bruun Niels H. , Bender Lars , Møller Tina , Thomsen Helle H. , Ebbesen Finn 
Published: November 2024

Abstract

Background
Around 2–6% of term or late preterm neonates receive phototherapy for hyperbilirubinemia. Standard treatment today is overhead phototherapy. A new device has been developed, the BiliCocoon, where the neonates are “wrapped” presumably making them more comfortable. The aim was to compare the efficacy and performance of the BiliCocoon with overhead LED phototherapy.

Methods
A randomized open-label multicenter trial in three Danish neonatal units. Healthy hyperbilirubinemic neonates, gestational age ≥33 weeks and postnatal age 24 h to 14 days were randomized to 24 hours’ of treatment with BiliCocoon or overhead blue LED phototherapy with an equal level of irradiance. A mixed effect model with random effect by center was used to compare the percentage decrease in total serum bilirubin (TSB) between the treatments.

Results
Totally 83 neonates were included. Mean TSB reduction in the BiliCocoon group (N = 42), adjusted for baseline TSB, was significantly lower than in the overhead LED group (N = 41), 29% vs. 38% (p-value < 0.01). Overall difference in temperature by treatment (BiliCocoon vs overhead) was 0.70 [0.37; 1.02] °C, p-value < 0.01.

Conclusion
Bilirubin reducing efficacy of BiliCocoon was lower than that of overhead phototherapy, but it was sufficient for nearly all neonates during 24 hours of treatment.

Impact

The BiliCocoon has a bilirubin reducing efficacy, sufficient for almost all neonates during 24 hours of phototherapy.

The BiliCocoon does not have an equal bilirubin reducing efficacy as overhead phototherapy.

The duration of light exposure was longer for the neonates treated in the BiliCocoon.

A few neonates can be exclusively breastfed in the BiliCocoon throughout the treatment.

The reason for stopping breastfeeding in the BiliCocoon was most often, that the neonates developed hyperthermia.
Real-world evidence for pembrolizumab in non-small cell lung cancer: a nationwide cohort study
Authors: Hektoen Helga H. , Tsuruda Kaitlyn M. , Fjellbirkeland Lars , Nilssen Yngvar , Brustugun Odd Terje , Andreassen Bettina K. 
Published: November 2024

Abstract
Background
Based on favourable results from clinical trials, immune checkpoint inhibitors (ICI) have become the standard first line (1 L) systemic anticancer treatment (SACT) for advanced stage non-small cell lung cancer (NSCLC) without targetable mutations. We evaluate whether these results are generalizable to everyday clinical practice and compare overall survival (OS) of patients treated with ICI to a historical cohort of patients treated with chemotherapy and results from clinical trials.

Methods
Our study comprised all advanced NSCLC patients initiating SACT in 2012–21 in Norway. Clinical characteristics and treatment information was retrieved from Norwegian Health Registries.

Results
Survival for all 8416 advanced NSCLC patients treated with SACT increased concurrently with the gradual implementation of ICIs. Median OS of patients treated with 1 L pembrolizumab after 2017 was better (mono-/combination therapy: 13.8/12.8 months) than for patients treated with chemotherapy before 2017 (8.0 months). Although median OS for patients treated with pembrolizumab was lower in clinical practice than clinical trials (Keynote-024/189: 26.3/22.0 months), the survival benefit relative to chemotherapy was similar.

Conclusion
Our nationwide study demonstrated a survival benefit over conventional chemotherapy of a similar magnitude as observed in clinical trials and confirms the effectiveness of pembrolizumab in routine clinical practice.
The structure and function of P5A-ATPases
Authors: Li Ping , Bågenholm Viktoria , Hägglund Per , Lindkvist-Petersson Karin , Wang Kaituo , Gourdon Pontus 
Published: November 2024

AbstractEndoplasmic reticulum (ER) membrane resident P5A-ATPases broadly affect protein biogenesis and quality control, and yet their molecular function remains debated. Here, we report cryo-EM structures of a P5A-ATPase, CtSpf1, covering multiple transport intermediates of the E1 → E1-ATP → E1P-ADP → E1P → E2P → E2.Pi → E2 → E1 cycle. In the E2P and E2.Pi states a cleft spans the entire membrane, holding a polypeptide cargo molecule. The cargo includes an ER luminal extension, pinpointed as the C-terminus in the E2.Pi state, which reenters the membrane in E2P. The E1 structure harbors a cytosol-facing cavity that is blocked by an insertion we refer to as the Plug-domain. The Plug-domain is nestled to key ATPase features and is displaced in the E1P-ADP and E1P states. Collectively, our findings are compatible with a broad range of proteins as cargo, with the P5A-ATPases serving a role in membrane removal of helices, although insertion/secretion cannot be excluded, as well as with a mechanistic role of the Plug-domain.
Talin and vinculin combine their activities to trigger actin assembly
Authors: Wang Hong , Said Rayan , Nguyen-Vigouroux Clémence , Henriot Véronique , Gebhardt Peter , Pernier Julien , Grosse Robert , Le Clainche Christophe 
Published: November 2024

AbstractFocal adhesions (FAs) strengthen their link with the actin cytoskeleton to resist force. Talin-vinculin association could reinforce actin anchoring to FAs by controlling actin polymerization. However, the actin polymerization activity of the talin-vinculin complex is not known because it requires the reconstitution of the mechanical and biochemical activation steps that control the association of talin and vinculin. By combining kinetic and binding assays with single actin filament observations in TIRF microscopy, we show that the association of talin and vinculin mutants, mimicking mechanically stretched talin and activated vinculin, triggers a sequential mechanism in which filaments are nucleated, capped and released to elongate. In agreement with these observations, FRAP experiments in cells co-expressing the same constitutive mutants of talin and vinculin revealed accelerated growth of stress fibers. Our findings suggest a versatile mechanism for the regulation of actin assembly in FAs subjected to various combinations of biochemical and mechanical cues.
Parity-independent Kondo effect of correlated electrons in electrostatically defined ZnO quantum dots
Authors: Noro Kosuke , Kozuka Yusuke , Matsumura Kazuma , Kumasaka Takeshi , Fujiwara Yoshihiro , Tsukazaki Atsushi , Kawasaki Masashi , Otsuka Tomohiro 
Published: November 2024

AbstractQuantum devices such as spin qubits have been extensively investigated in electrostatically confined quantum dots using high-quality semiconductor heterostructures like GaAs and Si. Here, we present a demonstration of electrostatically forming the quantum dots in ZnO heterostructures. Through the transport measurement, we uncover the distinctive signature of the Kondo effect independent of the even-odd electron number parity, which contrasts with the typical behavior of the Kondo effect in GaAs. By analyzing temperature and magnetic field dependences, we find that the absence of the even-odd parity in the Kondo effect is not straightforwardly interpreted by the considerations developed for conventional semiconductors. We propose that, based on the unique parameters of ZnO, electron correlation likely plays a fundamental role in this observation. Our study not only clarifies the physics of correlated electrons in the quantum dot but also holds promise for applications in quantum devices, leveraging the unique features of ZnO.
Enhanced production of 60Fe in massive stars
Authors: Spyrou A. , Richman D. , Couture A. , Fields C. E. , Liddick S. N. , Childers K. , Crider B. P. , DeYoung P. A. , Dombos A. C. , Gastis P. , Guttormsen M. , Hermansen K. , Larsen A. C. , Lewis R. , Lyons S. , Midtbø J. E. , Mosby S. , Muecher D. , Naqvi F. , Palmisano-Kyle A. , Perdikakis G. , Prokop C. , Schatz H. , Smith M. K. , Sumithrarachchi C. , Sweet A. 
Published: November 2024

AbstractMassive stars are a major source of chemical elements in the cosmos, ejecting freshly produced nuclei through winds and core-collapse supernova explosions into the interstellar medium. Among the material ejected, long-lived radioisotopes, such as 60Fe (iron) and 26Al (aluminum), offer unique signs of active nucleosynthesis in our galaxy. There is a long-standing discrepancy between the observed 60Fe/26Al ratio by γ-ray telescopes and predictions from supernova models. This discrepancy has been attributed to uncertainties in the nuclear reaction networks producing 60Fe, and one reaction in particular, the neutron-capture on 59Fe. Here we present experimental results that provide a strong constraint on this reaction. We use these results to show that the production of 60Fe in massive stars is higher than previously thought, further increasing the discrepancy between observed and predicted 60Fe/26Al ratios. The persisting discrepancy can therefore not be attributed to nuclear uncertainties, and points to issues in massive-star models.
Design of a square-horn hybrid plasmonic nano-antenna array using a flat lens for optical wireless applications with beam-steering capabilities
Authors: Helmy Fatma E. , Ibrahim Ibrahim I. , Saleh Amany M. 
Published: November 2024

AbstractThis paper introduces a Hybrid Plasmonic Nano-Antenna (HPNA) with a gradient-index dielectric flat lens modeled with different materials to enhance and steer the radiation in a particular direction based on a phase shift array. Firstly, the design of hybrid plasmonic Nano-Antenna (NA) is introduced and analyzed considering different horn-shapes such as diamond, hexagonal, circular, rectangular, and square shapes. The commercial software Computer Simulation Technology-Microwave Studio (CST-MWS) is used to analyze the radiation characteristics of the plasmonic NAs at the standard telecommunication wavelength of 1,550 nm. The produced horn-shaped nano-antenna made up from gold cladding with low- and high-index dielectric materials of SiO2 and InGaAs, respectively. The gain of the Square Horn shape Hybrid Plasmonic Nano-Antenna (SHHPNA) achieves the greatest gain with a value of 10.7 dBi at the desired frequency and the return loss reached -18.09 dB due to the wide aperture area for SHHPNA, which results in a narrower beam-width and higher gain. Moreover, by using two different shapes of dielectric flat lens to enhance the antenna’s performance by improving directivity while correspondingly reducing beam-width, the gain is enhanced and reaches 16.7 for SHHPNA with a circular lens and 16.9 for SHHPNA with a rectangular lens compared with the traditional NA that equal to 9.03 dBi. The main lobe for SHHPNA with each lens is more directed, with Side Lobe Level (SLL) and Half Power Beam-Width (HPBW) of -13.1 dB and 16.5° for SHHPNA with a circular lens and -15.1 dB and 15.4° for SHHPNA with a rectangular lens, respectively. In addition, the array configuration was investigated, and the gain was found to be 21 dBi for the single row array of 4×1 and 23.2 dB for the array of 3×3. Moreover, the array of 4×1 and 3×3 with +90° showed gains of 18.6 dBi and 20.7 dBi, respectively, compared to traditional paper with gains of 11.20 dBi and 13.1 dBi.
Design and predict the potential of imidazole-based organic dyes in dye-sensitized solar cells using fingerprint machine learning and supported by a web application
Authors: Elsenety Mohamed M. 
Published: November 2024

AbstractThis scientific paper presents a novel approach to explore and predict the potential of imidazole-based organic dyes for use in Dye-Sensitized Solar Cells (DSSCs) using a machine learning web application. The design of efficient and cost-effective organic dyes is critical to enhance the performance of DSSCs. Traditional experimental methods are time-consuming and resource-intensive, making it challenging to screen a large number of potential dyes. In this study, we propose a machine learning-based approach to accelerate the discovery process by predicting the photovoltaic performance of imidazole-based organic dyes. Machin learning predictions provide valuable insights into the expected PCE% and behaviors of the molecules toward DSSCs. Based on the RDKit library, several fingerprints such as Molecular ACCess System, Avalon, Daylight, Pharmacophore and Morgan with different radius (r2, r3, r4), were studied. In addition, more than 20 ML algorithms using different cross validation (3, 5, 7, 10) were also evaluated. Among of these, Deep Neural Network models of MLPRegressor algorithm based on the daylight fingerprint shows a significant coefficient of determination combined with the lowest errors. Utilize the trained ML models to screen of 50 million SMILE structure for identify promising imidazole and nitrogen-containing derivative as a doner group. By replacing the donor groups in the well-known MK2 dye structure with the top imidazole derivatives proposed by machine learning, significant improvements in PCE were observed, increasing from 7.70% to as high as 11.49%, representing nearly a 50% enhancement over the control. DFT calculations confirm the ML predictions and clarify the significantly higher oscillator strength and charge transfer properties of MK2-DM1, compared to MK2. This result provides a promising pathway for developing new dye materials that can push the efficiency limits of DSSCs, leading to more efficient solar energy conversion technologies in the future. In addition, a developed web application offers a user-friendly interface for researchers to input their molecular structures and obtain PCE% predictions toward DSSCs. This information can guide researchers in designing a new imidazole dye with high photovoltaic performance to validate and refine the predictions without time consuming.
The emotional effect of terrorism
Authors: Bove Vincenzo , Efthyvoulou Georgios , Ghazaryan Armine , Pickard Harry 
Published: November 2024

AbstractTerrorism causes emotional reactions among public audiences, with downstream consequences for their well-being, attitudes and policy preferences. We utilise a novel approach which harnesses a unique dataset of Twitter activity from 324K users to precisely capture emotional responses to terrorism. Our results demonstrate that terrorist attacks induce dramatic spikes in various discrete emotions of a negative valence, which vary based on the characteristics of the attacks. Furthermore, we show that the terrorism-induced effects on emotions are accompanied by changes in feelings about immigration.
Comparative toxicity of three variant oils and their nanoemulsions on the brown dog tick Rhipicephalus sanguineus
Authors: Abdel-Ghany Hoda S.M. , Ayoob Fathalla , Abdel-Shafy Sobhy , Soliman Ahmed A. F. , Gebely Mohamed A. , Abuowarda Mai 
Published: November 2024

AbstractTick control mainly depends on using chemical acaricides that have led to the emergence of resistant tick populations along with environmental hazards. Natural alternatives including essential oils are now widely used to avoid the undesirable effects of chemicals on human, animals and environment. In this study, three commercial oils (myrrh, patchouli, and cypress) and their nanoemulsions (NEs) were tested against Rhipicephalus sanguineus sensu lato unfed adults. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) were used to characterize the nanoemulsions. Four concentrations with three replicates were used in the bioassay of oils and NEs against ticks using an adult immersion test. Furthermore, a toxicity study of the three oils and their NEs using normal fibroblast cells (BJ-1) was performed. TEM revealed particle size ranges from 29 to 211 nm with spherical droplets. The droplet size and polydispersity index were (29.30 nm & 0.367), (211.6 nm & 0.221) and (164.2 nm & 0.237) for myrrh NE, patchouli NE, and cypress NE, respectively. Myrrh and patchouli oils recorded high acaricidal activity followed by cypress oil with LC50 value 5 days after treatment of 9.01, 12.40, and 15.21%, respectively. The acaricidal efficacy of oil was potentiated in the NEs form which was proved by the reduction in LC50 values that were recorded 7 days after treatment 4.17, 8.57, and 5.04%, for myrrh, patchouli, and cypress NE, respectively. As an alternative for lab animals, we applied the cytotoxicity of myrrh, patchouli, and cypress on normal fibroblast cells. The oils showed low cytotoxic activity of 10.6, 21.5, and 23.6% for Myrrh, Patchouli, and Cypress, respectively. The nanoemulsion was revealed to be safe for normal cells up to a concentration of 0.62% (cytotoxicity%= 24.4, 34.4, and 16.3%, respectively), and the moderate cytotoxic effect appeared at around a concentration of 1.25% (cytotoxicity%= 42.2%, 57.0%, and 36.8% respectively). In conclusion, the three oils and their NEs have good acaricidal activity against Rhipicephalus sanguineus unfed adults. Further toxicity studies on mammals are needed to ensure the safe use of these formulations for the control of ticks on infested animals.