bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jackhammer esophagus with and without esophagogastric junction outflow obstruction demonstrates altered neural control resembling type 3 achalasia
Authors: Quader Farhan , Mauro Aurelio , Savarino Edoardo , Tolone Salvatore , de Bortoli Nicola , Franchina Marianna , Ghisa Matteo , Edelman Krista , Jha Lokesh K. , Penagini Roberto , Gyawali C. Prakash 
Published: July 2019

AbstractBackgroundEsophageal hypercontractility can manifest with and without esophagogastric junction (EGJ) outflow obstruction. We investigated clinical presentations and motility patterns in patients with esophageal hypercontractile disorders.MethodsEsophageal HRM studies fulfilling Chicago Classification 3.0 criteria for jackhammer esophagus (distal contractile integral, DCI >8000 mmHg.cm.s in ≥ 20% swallows) with (n = 30) and without (n = 83) EGJ obstruction (integrated relaxation pressure, IRP > 15 mm Hg) were retrospectively reviewed from five centers (4 in Europe, 1 in US). Single swallows (SS) and multiple rapid swallows (MRS) were analyzed using HRM software tools (IRP, DCI, distal latency, DL); MRS: SS DCI ratio >1 defined contraction reserve. Comparison groups were achalasia type 3 (n = 72, positive control for abnormal inhibition and EGJ obstruction) and healthy controls (n = 18). Symptoms, HRM metrics, and MRS contraction reserve were analyzed within jackhammer subgroups and comparison groups.Key ResultsThe esophageal smooth muscle was excessively stimulated at baseline in jackhammer subgroups, with lack of augmentation following MRS identified more often compared with controls (P = .003) and type 3 achalasia (P = .07). Consistently abnormal inhibition was identified in type 3 achalasia (47%), and to a lower extent in jackhammer with obstruction (37%, P = .33), jackhammer esophagus (28%, P = .01), and controls (11%, P < .01 compared with type 3 achalasia). Perceptive symptoms (heartburn, chest pain) were common in jackhammer esophagus (P < .01 compared with type 3 achalasia), while transit symptoms (dysphagia) were more frequent with presence of EGJ obstruction (P ≤ .01 compared with jackhammer without obstruction).Conclusions and inferencesThe balance of excessive excitation and abnormal inhibition defines clinical and manometric manifestations in esophageal hypercontractile disorders.
Hybridization and a loss of sex shape genome‐wide diversity and the origin of species in the evening primroses (Oenothera, Onagraceae)
Authors: Hollister Jesse D. , Greiner Stephan , Johnson Marc T. J. , Wright Stephen I. 
Published: July 2019

Summary

Hybridization is thought to promote speciation in at least two ways – by fixation of heterozygosity from diploid progenitors in allopolyploids, and by generation of transgressive phenotypes and shifting fitness optima during homoploid hybrid speciation. While recent studies support a hybrid origin for a growing number of species, the extent to which hybrid origins shape patterns of diversity in asexual species remains underexplored.

Here we employed transcriptome sequencing and population genomic analysis to describe patterns of genomic variation in the 13 species belonging to Oenothera subsection Oenothera. Eight of these species are functionally asexual and arose by hybrid speciation from parents spanning a range of phylogenetic divergence.

We showed that genomic divergence between parents has been retained as heterozygosity in functionally asexual species, and that genome‐wide levels of heterozygosity in these asexuals largely reflects the divergence of parental haplotypes coupled with a breakdown in recombination and segregation across the genome.

These results show that divergence between parental species and loss of sex in hybrids shape patterns of whole‐genome diversity and the origin of asexual species.
Innovation as a policy strategy for natural resource protection
Authors: Peterson Jeffrey M. 
Published: July 2019

AbstractGrowing global food demands place major strains on water resources, including quality impairments and increased water scarcity. Drawing on the largely separate bodies of literature on externalities and technological innovation, this article develops a dynamic framework to explore the long‐term impacts of alternative policy approaches to the agricultural impacts on water resources. Environmental policies, which focus on correcting environmental externalities, lead to an overall gain because costs to farmers are more than offset by reduced environmental damages. Technology policies, which direct public investments into agricultural eco‐innovations, lead to benefits for farmers as well as the environment. Joint implementation of both types of policies leads to the largest overall gain. In principle, a technology policy alone could have greater environmental benefits than an environmental policy alone. This outcome is most likely in cases where the productivity effect of new technology is large and the cost of research is low.Recommendations for research managers

As an alternative to traditional environmental policy, investments in research can provide win–win solutions that benefit the environment and agricultural producers.
Conceivably, eco‐innovations could lead to environmental conditions that are better than those achieved by environmental policy alone.
Adding research investments to existing environmental policy would lead to further improvements in environmental quality while also benefitting farmers.
Unlike environmental policies that are perceived to impose costs on agriculture, technology policies impart benefits to farmers and are less likely to face political opposition from industry.
Technology policies are likely to be the most effective when eco‐innovation leads to technologies that meaningfully reduce environmental impacts and also raise farm productivity.
The Impact of Tropical Storms on Households: Evidence from Panel Data on Consumption
Authors: Henry Michael , Spencer Nekeisha , Strobl Eric 
Published: July 2019

AbstractThis paper investigates the impact of tropical storms on Jamaican household consumption. We build a panel data set that follows individual households over time thus enabling us to take account of time invariant household and location unobservables that could be correlated with mean tropical storm exposure. Our results show that while the average damaging hurricane reduces per capita consumption by approximately 1.1%, more destructive events can cause losses multiple times this amount. There are, however, heterogeneous impacts across households, where only those that live in buildings with less wind resistant walls are affected. Additionally, we find that households are able to partially buffer the negative impact on consumption through remittances and savings, as well as by shifting funds away from non‐regular expenditures. Again, households differ in the nature of this buffering according to the wind resistance of their buildings.
Dental deaths in Italy as reported by online press articles
Authors: Minoli Margherita , Zechini Giacomo , Capparé Paolo , Landoni Giovanni 
Published: July 2019

AbstractObjectivesMortality on the dental chair is a rare and underreported event. This study aimed to identify all deaths that occurred during dental procedures in Italy.MethodsWe searched PubMed/Medline, Scopus, and Internet archives looking for patients who died before, during, or after a dental procedure in Italy from 1990 to 2019.ResultsAll the 36 identified fatal events were reported by national or regional newspapers, and none was reported by scientific databases. Interestingly, no cases regarding patients ≤16 years old were found and there was no variation in the number of reported deaths over the years. Most of the cases (n = 29) occurred in out‐of‐hospital private dental offices. Tooth extraction represented the most frequent culprit operation (39%), while myocardial infarction (28%) was the leading cause of death, followed by cardiac arrest (25%), allergies (11%), and infections (8%). In four cases, death was preprocedural, in 10 intraprocedural and in 21 postprocedural. In 17 cases, a temporal association between injection of anesthesia/sedation and death was observed.ConclusionThis is the first report on Italian dental procedure‐related deaths. Most of these deaths were only temporally associated with a dental procedure and could not to be attributed to malpractice.
Effectiveness of Combination of Ultrasonography‐Guided Pulsed Radiofrequency Neuromodulation With Steroid at the Suprascapular Nerve in Chronic Shoulder Pain
Authors: Sinha Pratyusha , Sarkar Biplab , Goswami Subrata , Ray Karmakar Prasanta , Dasgupta Santi Ranjan , Basu Sagarmay 
Published: July 2019

AbstractBackgroundSuprascapular nerve (SSN) block is a useful tool for pain control of different chronic shoulder pain syndromes. If the short‐term effect of nerve block using local anesthetics is not sufficient, pulsed radiofrequency (PRF) neuromodulation of the SSN may provide long‐term pain relief.Aim of InvestigationThe aim of this study was to determine the effectiveness of ultrasonography‐guided PRF of the SSN for management of chronic shoulder pain.Subjects and MethodThirty patients with chronic shoulder pain underwent diagnostic ultrasonography‐guided SSN block. After confirmation of positive results (>50% pain relief) via diagnostic testing, PRF of the SSN was performed in 27 patients, followed by application of dexamethasone; however, 2 patients had negative results with diagnostic block and 1 patient dropped out after positive results with diagnostic block. Pain was recorded using the VAS, and active range of motion of the affected shoulder was measured by goniometry (flexion, extension, adduction, abduction, external rotation, internal rotation). Assessments were done on day 0 and after 4, 8, 12, and 24 weeks.Statistical TestOne‐way analysis of variance testing.ResultsThe VAS score decreased significantly (P < 0.05) immediately after injection, and pain reduction was sustained for up to 24 weeks. Active range of motion in all directions also increased significantly (P < 0.5) after the procedure.ConclusionPRF of the SSN under ultrasonography guidance is a safe and effective treatment modality for management of chronic shoulder pain. The effect of a combination of PRF and a short‐acting corticosteroid lasts up to 24 weeks, thereby assisting patients in undergoing relatively painless physiotherapy.
Genetic polymorphism in core promoter sequence of ACTRIIB gene and association analysis with growth traits in chicken
Authors: Guru Vishnu Pothanaboyina , Bhattacharya Tarun Kumar , Bhushan Bharat , Paswan Chandan , Rajendra Prasad Athe , Divya Devara 
Published: July 2019

AbstractMolecular breeding exploiting candidate genes is burgeoning reproductive approach to improve growth traits in poultry. The activin type IIB receptor (ACTRIIB) is a negative growth regulator, modulating action of many muscle growth regulators. PCR–single‐strand conformation polymorphism was employed to unravel polymorphism in promoter region of the ACTRIIB gene and delineate its association with growth traits in Aseel and control broiler (CB). Analysis of 5′ promoter region (1122bp) of ACTRIIB gene identified five SNPs, that is g. [56 G > C (SNP1), 352A > C (SNP2), 580G > A (SNP3), 625C > T (SNP4) and 962C > T (SNP5)] at SMAD, paired box 7 homeodomain binding motif, GC box and bHLH‐PAS type transcription factors in CB and Aseel. CB had significantly higher body weight (BW) and average daily gain (ADG) at all SNP sites, except at SNP 1. The haplotype construction resulted 8 haplotypes in CB and Aseel population. The BW and ADG differed significantly (p < .05) at all ages in CB and Aseel. The diplotypes H1H8 and H1H4 manifested higher BW and ADG, while diplotypes H3H8 and H3H7 displayed BW and ADG at each age in both lines (p < .05). Aseel exhibited higher expression of ACTRIIB gene than CB by 70.17, 4.83, 1.41, 2.38, 5.13, 1.20, 2.90, 6.53 and 11.75 times for h1h2, h1h3, h1h4, h1h6, h1h7, h1h8 h3h4, h3h7 and h3h8, respectively. The H3H8 and H3H7 diplotypes exhibited higher level of mRNA and protein than H1H8 and H1H4. The regulatory upstream region of ACTRIIB gene demonstrates high degree of genetic diversity and can be harnessed as potential marker in genetic selection programmes for increasing meat production.
Determination and validation of peak fat oxidation in endurance‐trained men using an upper body graded exercise test
Authors: Hansen Mikkel Thunestvedt , Rømer Tue , Frandsen Jacob , Larsen Steen , Dela Flemming , Helge Jørn Wulff 
Published: July 2019

Peak fat oxidation rate (PFO) and the intensity that elicits PFO (Fatmax) are commonly determined by a validated graded exercise test (GE) on a cycling ergometer with indirect calorimetry. However, for upper body exercise fat oxidation rates are not well elucidated and no protocol has been validated. Thus, our aim was to test validity and inter‐method reliability for determination of PFO and Fatmax in trained men using a GE protocol applying double poling on a ski‐ergometer. PFO and Fatmax were assessed during two identical GE tests (GE1 and GE2) and validated against separated short continuous exercise bouts (SCE) at 35%, 50%, and 65% of V̇O2peak on the ski‐ergometer in 10 endurance‐trained men (V̇O2peak: 65.1 ± 1.0 mL·min−1·kg−1, mean ± SEM). Between GE tests no differences were found in PFO (GE1: 0.42 ± 0.03; GE2: 0.45 ± 0.03 g·min−1, P = .256) or Fatmax (GE1: 41 ± 2%; GE2: 43 ± 3% of V̇O2peak, P = .457) and the intra‐individual coefficient of variation (CV) was 8 ± 2% and 11 ± 2% for PFO and Fatmax, respectively. Between GE and SCE tests, PFO (GEavg: 0.44 ± 0.03; SCE; 0.47 ± 0.06 g·min−1, P = .510) was not different, whereas a difference in Fatmax (GEavg: 42 ± 2%; SCE: 52 ± 4% of V̇O2peak, P = .030) was observed with a CV of 17 ± 4% and 15 ± 4% for PFO and Fatmax, respectively. In conclusion, GE has a high day‐to‐day reliability in determination of PFO and Fatmax in trained men, whereas it is unclear if PFO and Fatmax determined by GE reflect continuous exercise in general.
Do Charter School Students Outperform Public School Students on Standardized Tests in Michigan?
Authors: Murphy Kevin J. , Izraeli Oded 
Published: July 2019

ObjectiveWe compare academic achievement in charter schools versus two types of traditional public school in the State of Michigan over a 10‐year period. Charter schools serve as a reform measure for failing public schools, so the natural research question is: Do charter schools generate higher achievement levels than observationally comparable public schools?MethodsWe have assembled a longitudinal data set spanning academic years 2002/2003–2011/2012 containing proficiency rates on standardized math and reading tests for Grades 4, 7, and 11. Our set of control variables includes demographic measures, free lunch eligibility, school characteristics, funding per student, and locational measures. We model unobserved heterogeneity using random effects estimation.ResultsWe find that Michigan charter schools significantly underperform traditional public schools in both subjects and in all three grade levels early in the study period. These gaps narrow considerably, and in some cases disappear, by the end of the period.ConclusionMichigan is noteworthy among states with charter schools for its deregulated and competitive charter environment. Our results suggest that Michigan charters nevertheless were doing about as well on the state's academic achievement tests as observationally comparable public schools by the end of the period.
Late Cretaceous Neo-Tethyan slab roll-back: Evidence from zircon U-Pb-O and whole-rock geochemical and Sr-Nd-Fe isotopic data of adakitic plutons in the Himalaya-Tibetan Plateau
Authors: Yin Changqing , Ou Jie , Long Xiaoping , Huang Fang , Zhang Jian , Li Shun , Wang Luojuan , Xia Xiaoping , He Xiaolan 
Published: July 2019

AbstractLate Cretaceous (ca. 100–80 Ma) magmatism in southern Lhasa subterrane records critical geological events, which can provide important insights into the regional tectonic evolution and geodynamic process of South Tibet. This study presents new zircon U-Pb ages, whole-rock geochemistry and Sr-Nd-Fe and zircon U-Pb-O isotopic data for two dioritic plutons in the southern Lhasa subterrane. Secondary ion mass spectrometry U-Pb dating on magmatic zircons from these rocks yielded a consistent age at ca. 90 Ma. The rocks exhibit variable SiO2 contents (52–59 wt%), high Fe2O3T contents (7.1–10.0 wt%), and low K2O/Na2O ratios (0.18–0.48). Most samples have high Al2O3 (17.0–19.5 wt%) and Sr (493–678 ppm), but low Yb (0.9–2.4 ppm) and Y (9–25.2 ppm) concentrations, and thus high Sr/Y (23–74) ratios, typical of adakite-like geochemical features. The adakitic rocks have relatively uniform initial 87Sr/86Sr isotopic ratios (0.7043–0.7046) and εNd(t) values (+3.67 to +4.16), indicating derivation from similar parental magmas. The δ56Fe values of whole-rock samples vary from 0.011 to 0.091‰ with an average of 0.045 ± 0.046‰ (two standard deviations), reflecting a homogeneous Fe isotopic composition, which is associated with melt-mantle interaction. In addition, the rocks are characterized by relatively high zircon δ18O values of 5.72–7.19‰, indicating the involvement of an 18O-enriched component during magma formation. The calculation of Al-in-hornblende barometer indicates that the adakitic rocks were emplaced at pressures of 6.4–9.8 kbar. Therefore, it is proposed that the adakitic rocks were most likely generated by partial melting of mantle wedge that had been previously modified by slab-melts at a relatively shallow depth, followed by minor fractional crystallization of hornblende. Taking into account previously published data in the southern Lhasa subterrane, we suggest that the ca. 90 Ma magmatism could be related to a period of Neo-Tethyan oceanic slab roll-back, which can provide new insights into the revolution process of the Neo-Tethyan ocean realm and the accretion of the Himalaya-Tibetan Plateau.
Simultaneous orthogonal shortening in the Afghan-Tajik Depression
Authors: McNab Fergus , Sloan R. Alastair , Walker Richard T. 
Published: July 2019

AbstractThe Afghan-Tajik Depression is a sedimentary basin in the Alpine-Himalayan mountain chain. It is traversed by series of north-south arcuate folds, suggesting that the basin is undergoing east-west compression. A second set of folds in the south of the depression runs east-west, crosscutting those trending north-south. We present results from teleseismic body waveform inversion and depth phase modeling for five recent earthquakes, and from detailed mapping of structures related to active faulting based on satellite imagery and topographic data. We argue that both sets of folds are active and that deformation is vertically partitioned, with north-south compression accommodated on east-west–trending thrust faults within the basement, and east-west compression accommodated on north-south–trending thrust faults above a detachment within the basin fill. The observation that orthogonal shortening can be accommodated simultaneously in this way has several important implications. Juxtaposed orthogonal fold systems identified in the geological record may not require temporally separate events, particularly in gravity-driven fold-and-thrust belts in foreland-basin settings. Pervasive detachment may limit the size of potential earthquakes by preventing single events from rupturing the entire seismogenic layer. However, it may also disguise geomorphic signatures of faulting and interseismic strain accumulation within the lower layer, hindering accurate seismic hazard assessment and regional tectonic interpretations.
Cenozoic tectono-thermal history of the southern Talkeetna Mountains, Alaska: Insights into a potentially alternating convergent and transform plate margin
Authors: Terhune Patrick J. , Benowitz Jeffrey A. , Trop Jeffrey M. , O’Sullivan Paul B. , Gillis Robert J. , Freymueller Jeffrey T. 
Published: July 2019

AbstractThe Mesozoic–Cenozoic convergent margin history of southern Alaska has been dominated by arc magmatism, terrane accretion, strike-slip fault systems, and possible spreading-ridge subduction. We apply 40Ar/39Ar, apatite fission-track (AFT), and apatite (U-Th)/He (AHe) geochronology and thermochronology to plutonic and volcanic rocks in the southern Talkeetna Mountains of Alaska to document regional magmatism, rock cooling, and inferred exhumation patterns as proxies for the region’s deformation history and to better delineate the overall tectonic history of southern Alaska. High-temperature 40Ar/39Ar thermochronology on muscovite, biotite, and K-feldspar from Jurassic granitoids indicates postemplacement (ca. 158–125 Ma) cooling and Paleocene (ca. 61 Ma) thermal resetting. 40Ar/39Ar whole-rock volcanic ages and 45 AFT cooling ages in the southern Talkeetna Mountains are predominantly Paleocene–Eocene, suggesting that the mountain range has a component of paleotopography that formed during an earlier tectonic setting. Miocene AHe cooling ages within ∼10 km of the Castle Mountain fault suggest ∼2–3 km of vertical displacement and that the Castle Mountain fault also contributed to topographic development in the Talkeetna Mountains, likely in response to the flat-slab subduction of the Yakutat microplate. Paleocene–Eocene volcanic and exhumation-related cooling ages across southern Alaska north of the Border Ranges fault system are similar and show no S-N or W-E progressions, suggesting a broadly synchronous and widespread volcanic and exhumation event that conflicts with the proposed diachronous subduction of an active west-east–sweeping spreading ridge beneath south-central Alaska. To reconcile this, we propose a new model for the Cenozoic tectonic evolution of southern Alaska. We infer that subparallel to the trench slab breakoff initiated at ca. 60 Ma and led to exhumation, and rock cooling synchronously across south-central Alaska, played a primary role in the development of the southern Talkeetna Mountains, and was potentially followed by a period of southern Alaska transform margin tectonics.
Drenov Grič black limestone: a heritage stone from Slovenia
Authors: Kramar Sabina , Žbona Nina , Bedjanič Mojca , Mladenović Ana , Rožič Boštjan 
Published: July 2019

Abstract
Drenov Grič black limestone is considered to be one of the most beautiful Slovenian natural stones due to its black colour interwoven with white veins. Over the centuries, it has been extracted from two major quarries located west of Ljubljana. One of these quarries has been declared a valuable natural feature of national importance and is protected as a natural monument. This well-stratified, Triassic (Carnian) micritic limestone occurs in 10–80 cm thick beds with thin marl interlayers. The limestone occasionally contains abundant fossil bivalves, gastropods and ostracods. It is relatively rich in carbonaceous and bituminous organic matter, which is responsible for the black colour of the stone. The stone has been widely used in Slovenian monuments. Many indoor and outdoor architectural elements have been constructed using this limestone, particularly during the Baroque period, which was known for its extensive use of black limestones in other European countries as well. The most significant use of this limestone has been recorded in sculpted portals and altars. Some important buildings, which were decorated utilizing this stone, have been declared cultural monuments of local or national importance. Use of this limestone was also documented in other European countries (Italy, Austria, Serbia) and worldwide (USA). When exposed to climatic influences, chromatic and salt weathering are recognized as the main deterioration phenomena for this limestone when used in monuments.