bluuebunny/crossref_metadata_2025_split huggingface dataset:
EARS to cyber incidents in health care
Authors: Jalali Mohammad S , Russell Bethany , Razak Sabina , Gordon William J 
Published: October 2018

Abstract

Background
Connected medical devices and electronic health records have added important functionality to patient care, but have also introduced a range of cybersecurity concerns. When a healthcare organization suffers from a cybersecurity incident, its incident response strategies are critical to the success of its recovery.

Objective
In this article, we identify gaps in research concerning cybersecurity response plans in healthcare. Through a systematic literature review, we develop aggregated strategies that professionals can use to construct better response strategies in their organizations.

Methods
We reviewed journal articles on cyber incident response plans in healthcare published in PubMed and Web of Science. We sought to collect articles on the intersection of cybersecurity and healthcare that focused on incident response strategies.

Results
We identified and reviewed 13 articles for cybersecurity response recommendations. We then extracted information such as research methods, findings, and implications. Finally, we synthesized the recommendations into a framework of eight aggregated response strategies (EARS) that fall under managerial and technological categories.

Conclusions
We conducted a systematic review of the literature on cybersecurity response plans in healthcare and developed a novel framework for response strategies that could be deployed by healthcare organizations. More work is needed to evaluate incident response strategies in healthcare.
Counting the Population and the Wealth in an “Unruly” Land: Census Making as a Social Process in Ottoman Kurdistan, 1830–50
Authors: Özok-Gündoğan Nilay 
Published: October 2018

Abstract
This article examines the earliest modern Ottoman censuses in Kurdistan in the mid-nineteenth century from a social history perspective. Echoing the efforts of its contemporaries, the Ottoman state set out to conduct its first modern population census in 1830. This early census reflected the state’s aims for standardization and centralization, yet it was conducted “successfully” only in provinces geographically close to the capital. In Kurdistan, a border area controlled by ancient Kurdish chiefdoms and tribes, the census remained a herculean task for over four decades. Following recent society-centered views of global census history, this article approaches the modern Ottoman census experience in this early period as a social process rather than a top down enterprise. It argues that what determined the content, structure, and the format of these early censuses was not the discussions in the meeting rooms of the Ottoman imperial bureaucracy but social encounters between local and central, state and nonstate actors situated in the locality.
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Chemotherapy in the Management of Adults With Newly Diagnosed Metastatic Brain Tumors
Authors: Sherman Jonathan H , Lo Simon S , Harrod Tom , Hdeib Alia , Li Yiping , Ryken Timothy , Olson Jeffrey J 
Published: October 2018

Abstract

QUESTION 1
Should patients with brain metastases receive chemotherapy in addition to whole brain radiotherapy (WBRT) for the treatment of their brain metastases?

TARGET POPULATION
This recommendation applies to adult patients with newly diagnosed brain metastases amenable to both chemotherapy and radiation treatment.

RECOMMENDATIONS

Level 1: Routine use of chemotherapy following WBRT for brain metastases is not recommended.

Level 3: Routine use of WBRT plus temozolomide is recommended as a treatment for patients with triple negative breast cancer.

QUESTION 2
Should patients with brain metastases receive chemotherapy in addition to stereotactic radiosurgery (SRS) for the treatment of their brain metastases?

RECOMMENDATIONS

Level 1: Routine use of chemotherapy following SRS is not recommended.

Level 2: SRS is recommended in combination with chemotherapy to improve overall survival and progression free survival in lung adenocarcinoma patients.

QUESTION 3
Should patients with brain metastases receive chemotherapy alone?

RECOMMENDATION

Level 1: Routine use of cytotoxic chemotherapy alone for brain metastases is not recommended as it has not been shown to increase overall survival.
Please see the full-text version of this guideline (https://www.cns.org/guidelines/guidelines-treatment-adults-metastatic-brain-tumors/chapter_5) for the target population of each recommendation.
Cigarette Smoking Quit Rates Among Persons With Serious Psychological Distress in the United States From 2008 to 2016: Are Mental Health Disparities in Cigarette Use Increasing?
Authors: Streck Joanna M , Weinberger Andrea H , Pacek Lauren R , Gbedemah Misato , Goodwin Renee D 
Published: October 2018

Abstract

Introduction
Prior work suggests that the prevalence of cigarette smoking is persistently higher among people with mental health problems, relative to those without. Lower quit rates are one factor that could contribute to higher prevalence of smoking in this group. This study estimated trends in the cigarette quit rates among people with and without past-month serious psychological distress (SPD) from 2008 to 2016 in the United States.

Methods
Data were drawn from 91 739 adult participants in the 2008–2016 National Survey on Drug Use and Health, a repeated, cross-sectional, national survey. Linear time trends of cigarette quit rates, stratified by past-month SPD, were assessed using logistic regression models with continuous year as the predictor.

Results
Cigarette quit rates among individuals with past-month SPD were lower than among those without SPD every year from 2008 to 2016. Quit rates did not change appreciably among those with past-month SPD (odds ratio = 1.02 [0.99, 1.06]) from 2008 to 2016, whereas quit rates increased among those without past-month SPD (odds ratio = 1.02 [1.01, 1.02]).

Conclusions
In the United States, quit rates among individuals with past-month SPD are approximately half than quit rates of those without SPD and have not increased over the past decade. This discrepancy in quit rates may be one factor driving increasing disparities in prevalence of smoking among those with versus without mental health problems. Tobacco control efforts require effective and targeted interventions for those with mental health problems.

Implications
Cigarette smoking quit rates have not increased among persons with serious mental health problems over the past decade. This work extends prior findings showing that smoking prevalence is not declining as quickly among persons with serious mental health problems. Findings suggest that diverging trends in quit rates are one possible driver of the persistent disparity in smoking by mental health status. Innovation in both tobacco control and targeted interventions for smokers with mental health problems is urgently needed.
Complete Bilateral Brachial Plexus Injury from Rhabdomyolysis and Compartment Syndrome: Surgical Case Report
Authors: Tonetti Daniel A , Tarkin Ivan S , Bandi Kiran , Moossy John J 
Published: October 2018

Abstract

BACKGROUND AND IMPORTANCE
Acute bilateral brachial plexus injury is rare and usually a result of traction injury. Immediate operative intervention is reserved for rare cases of ongoing compression of the plexus; the role for acute decompression of the brachial plexus secondary to compartment syndrome has not been previously described. In this report, we describe the technique and role for urgent brachial plexus decompression.

CLINICAL PRESENTATION
A 32-yr-old man presented with acute complete bilateral brachial plexus palsy due to focal rhabdomyolysis and brachial plexus compression after a night of excess alcohol and methadone ingestion. He had complete loss of motor and sensory function from C5 to T1, with the exception of partial sensory sparing of the C5 dermatome. Magnetic resonance imaging demonstrated diffuse muscular edema of the supraclavicular and infraclavicular fossae in addition to the pectoralis muscles and the deltoids bilaterally. He underwent urgent surgical decompression of his supraclavicular and infraclavicular fossae with fasciotomies of the pectoral muscles and the anterior deltoids, allowing direct visualization and decompression of the entire brachial plexus resulting in a near-complete functional recovery.

CONCLUSION
Neurosurgeons should include brachial plexus compression due to compartment syndrome in the differential diagnosis of patients with acute upper extremity weakness, particularly when associated with prolonged immobilization and/or substance abuse. Prompt surgical decompression should be performed in these patients if imaging and laboratory data suggest compartment syndrome and resultant neurological deficit.
Colors of Centaurs observed by the Subaru/Hyper Suprime-Cam and implications for their origin
Authors: Sakugawa Haruka , Terai Tsuyoshi , Ohtsuki Keiji , Yoshida Fumi , Takato Naruhisa , Lykawka Patryk Sofia , Wang Shiang-Yu 
Published: October 2018

Abstract
Centaurs have orbits between Jupiter and Neptune and are thought to originate from the trans-Neptunian region. Observations of surface properties of Centaurs and comparison with those of trans-Neptunian objects (TNOs) would provide constraints on their origin and evolution. We analyzed imaging data of nine known Centaurs observed by the Hyper Suprime-Cam (HSC) installed on the Subaru Telescope with the g- and i-band filters. Using the data available in the public HSC data archive, as well as those obtained by the HSC Subaru Strategic Program (HSC-SSP) by the end of 2017 June, we obtained the g − i colors of the nine Centaurs. We compared them with those of known TNOs in the HSC-SSP data obtained by T. Terai et al. (2018, PASJ, 70, S40). We found that the color distribution of the nine Centaurs is similar to that of those TNOs with high orbital inclinations, but distinct from those TNOs with low orbital inclinations. We also examined correlations between the colors of these Centaurs and their orbital elements and absolute magnitude. The Centaurs’ colors show a moderate positive correlation with semi-major axis, while no significant correlations between the color and other orbital elements or absolute magnitude were found for these Centaurs. On the other hand, recent studies on Centaurs with larger samples show interesting correlations between their color and absolute magnitude or orbital inclination. We discuss how our data fit in these previous studies, and also discuss implications of these results for their origin and evolution.
Stably free cancellation for group rings of metacyclic type
Authors: Evans J D P 
Published: October 2018

Abstract
Let p,q be primes such that q|p−1. Write Fn for the free group of rank n≥1 and let G(p,q)=Cp⋊Cq. We show that any stably free module over Z[G(p,q)×Fn] is necessarily free.
PATIENT DOSE IN DIGITAL RADIOGRAPHY UTILISING BMI CLASSIFICATION
Authors: Metaxas Vasileios I , Messaris Gerasimos A , Lekatou Aristea N , Petsas Theodore G , Panayiotakis George S 
Published: October 2018

Abstract
Dose audit is important towards optimisation of patients’ radiation protection in diagnostic radiography. In this study, the effect of the body mass index (BMI) on radiation dose received by 1869 adult patients undergoing chest, abdomen, lumbar spine, kidneys and urinary bladder (KUB) and pelvis radiography in an X-ray room with a digital radiography system was investigated. Patients were categorised into three groups (normal, overweight and obese) based on the BMI values. The patients’ entrance surface air kerma (ESAK) and the effective dose (ED) were calculated based on the X-ray tube output, exposure parameters and technical data, as well as utilising appropriate conversion coefficients of the recorded kerma area product (KAP) values. The local diagnostic reference levels (LDRLs) were established at the 75th percentile of the distribution of ESAK and KAP values. Statistically, a significant increase was found in ESAK, KAP and ED values, for all examinations, both for overweight and obese patients compared to normal patients (Mann–Whitney test, p < 0.0001). Regarding the gender of the patients, a statistically significant increase was found in the dose values for male patients compared to female patients, except for the chest LAT examinations (Mann–Whitney test, p = 0.06). The percentage increase for chest PA, chest LAT, abdomen AP, lumbar spine AP, lumbar spine LAT, pelvis AP and KUB AP in overweight patients was 75%, 100%, 136%, 130%, 70%, 66% and 174% for median ESAK, 67%, 81%, 135%, 134%, 85%, 63% and 172% for median KAP, as well as 89%, 54%, 146%, 138%, 82%, 57% and 183% for median ED values, respectively. For obese patients, the corresponding increases were 200%, 186%, 459%, 345%, 203%, 150% and 785% for median ESAK, 200%, 185%, 423%, 357%, 227%, 142% and 597% for median KAP, as well as 222%, 156%, 446%, 363%, 218%, 136% and 625% for median ED. The corresponding LDRLs for overweight patients were 0.17 mGy, 1.21 mGy, 3.74 mGy, 7.70 mGy, 7.99 mGy, 4.07mGy, 5.03 mGy and 0.13 Gy cm2, 0.69 Gy cm2, 2.35 Gy cm2, 2.10 Gy cm2, 2.59 Gy cm2, 2.13 Gy cm2, 2.49 Gy cm2 in terms of ESAK and KAP values, respectively, while in the case of obese patients were 0.28 mGy, 1.82 mGy, 7.26 mGy, 15.10 mGy, 13.86 mGy, 6.89 mGy, 13.40 mGy and 0.21 Gy cm2, 1.10 Gy cm2, 4.68 Gy cm2, 4.01 Gy cm2, 4.80 Gy cm2, 3.27 Gy cm2, 6.02 Gy cm2, respectively. It can be concluded that overweight and obese patients received a significantly increased radiation dose. Careful adjustment of imaging protocols is needed for these patients to reduce patient dose, while keeping the image quality at an acceptable level. Additional studies need to be conducted for these patient groups, that could further contribute to the development of radiation protection culture in diagnostic radiography.
Interprofessional Graduate Students’ Perspectives on Caring for Vulnerable Populations
Authors: Wright Patricia Moyle , Hanson Mary Jane S. 
Published: October 2018

Abstract
The purpose of this focus group study was to explore graduate students’ clinical experiences with vulnerable populations, perceived barriers to care, and ethical issues related to caring for disenfranchised groups. Furthermore, based on their experiences, the students were asked to share suggestions for curricular changes that could enhance care for vulnerable populations through interdisciplinary collaboration and multidisciplinary projects. The responses of the participants add to what is known about the care of vulnerable populations, offering a first-hand description of students’ preparation for work with vulnerable populations and the interdisciplinary team.
Developing an Instrument for Evidence-Based Peer Review of Faculty Online Teaching
Authors: Shelton Lora R. , Hayne Arlene N. 
Published: October 2018

Abstract
Peer review is a long-standing practice in academia that can supply valuable information for summative or formative evaluation. The purpose of this article is to present an evidence-based peer review instrument developed by faculty to assess faculty teaching and practice in the online environment. The peer review instrument was designed using the community of inquiry framework and best practices for online teaching. The elements of teaching presence, social presence, and cognitive presence serve as the basis for expected faculty behaviors.
Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults
Authors: Pun Brenda T. , Balas Michele C. , Barnes-Daly Mary Ann , Thompson Jennifer L. , Aldrich J. Matthew , Barr Juliana , Byrum Diane , Carson Shannon S. , Devlin John W. , Engel Heidi J. , Esbrook Cheryl L. , Hargett Ken D. , Harmon Lori , Hielsberg Christina , Jackson James C. , Kelly Tamra L. , Kumar Vishakha , Millner Lawson , Morse Alexandra , Perme Christiane S. , Posa Patricia J. , Puntillo Kathleen A. , Schweickert William D. , Stollings Joanna L. , Tan Alai , D’Agostino McGowan Lucy , Ely E. Wesley 
Published: October 2018

Objective:
Decades-old, common ICU practices including deep sedation, immobilization, and limited family access are being challenged. We endeavoured to evaluate the relationship between ABCDEF bundle performance and patient-centered outcomes in critical care.

Design:
Prospective, multicenter, cohort study from a national quality improvement collaborative.

Setting:
68 academic, community, and federal ICUs collected data during a 20-month period.

Patients:
15,226 adults with at least one ICU day.

Interventions:
We defined ABCDEF bundle performance (our main exposure) in two ways: 1) complete performance (patient received every eligible bundle element on any given day) and 2) proportional performance (percentage of eligible bundle elements performed on any given day). We explored the association between complete and proportional ABCDEF bundle performance and three sets of outcomes: patient-related (mortality, ICU and hospital discharge), symptom-related (mechanical ventilation, coma, delirium, pain, restraint use), and system-related (ICU readmission, discharge destination). All models were adjusted for a minimum of 18 a priori determined potential confounders.

Measurements and Results:
Complete ABCDEF bundle performance was associated with lower likelihood of seven outcomes: hospital death within 7 days (adjusted hazard ratio, 0.32; CI, 0.17–0.62), next-day mechanical ventilation (adjusted odds ratio [AOR], 0.28; CI, 0.22–0.36), coma (AOR, 0.35; CI, 0.22–0.56), delirium (AOR, 0.60; CI, 0.49–0.72), physical restraint use (AOR, 0.37; CI, 0.30–0.46), ICU readmission (AOR, 0.54; CI, 0.37–0.79), and discharge to a facility other than home (AOR, 0.64; CI, 0.51–0.80). There was a consistent dose-response relationship between higher proportional bundle performance and improvements in each of the above-mentioned clinical outcomes (all p < 0.002). Significant pain was more frequently reported as bundle performance proportionally increased (p = 0.0001).

Conclusions:
ABCDEF bundle performance showed significant and clinically meaningful improvements in outcomes including survival, mechanical ventilation use, coma, delirium, restraint-free care, ICU readmissions, and post-ICU discharge disposition.
The patient-centered oncology care on health care utilization and cost: A systematic review and meta-analysis
Authors: Liang Hailun , Tao Lei , Ford Eric W. , Beydoun May A. , Eid Shaker M. 
Published: October 2018

Background
Optimal cancer care entails coordination among multiple providers and continued follow-up and surveillance over time. The patient-centered care brings opportunities to improve the delivery of cancer care. The adoption of patient-centered oncology care (PCOC) is in its infancy. Evidence synthesis on the model’s effectiveness is scant.

Purposes
This is the first systemic review and meta-analysis on associations of PCOC with cancer patients’ adverse health care utilization, cost, patient satisfaction, and quality of care.

Methods
Our study was guided by the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) framework. Quality appraisal was performed using Downs and Black’s quality checklist. Study-level effect sizes of adverse health care utilization were computed using Cohen’s d and summarized using forest plots. Funnel plots were constructed to examine publication bias.

Results
Of 334 studies that were reviewed, 10 met eligibility criteria and were included into the final analysis. Many included studies implemented almost all six of patient-centered care core attributes, plus three additional attributes that specifically addressed cancer patients’ needs, including triage pathways, standardized and evidence-based symptom management, as well as support patient navigation. PCOC patients had lower utilization of inpatient care (standardized means difference [SMD] = −0.027, p = .049). Overall positive effect of PCOC on emergency department use was small and not significant (SMD = −0.023, p = .103). With regard to cost and quality of care, our narrative summaries showed an overall positive direction, though we found limitations in individual study quality that precluded a meta-analysis.

Public Implication
The results showed that it is possible to utilize patient-centered model to support best practice of cancer care. Early evidence shows that the PCOC model has potential to improve health care utilization, cost, and quality of care, but limited numbers of included articles and heterogeneity of those studies implied that more rigorous research is expected to further investigate the model’s effects.
Comprehensive analysis of long noncoding RNA expression in dorsal root ganglion reveals cell-type specificity and dysregulation after nerve injury
Authors: Baskozos Georgios , Dawes John M. , Austin Jean S. , Antunes-Martins Ana , McDermott Lucy , Clark Alex J. , Trendafilova Teodora , Lees Jon G. , McMahon Stephen B. , Mogil Jeffrey S. , Orengo Christine , Bennett David L. 
Published: October 2018

Abstract
Dorsal root ganglion (DRG) neurons provide connectivity between peripheral tissues and the spinal cord. Transcriptional plasticity within DRG sensory neurons after peripheral nerve injury contributes to nerve repair but also leads to maladaptive plasticity, including the development of neuropathic pain. This study presents tissue and neuron-specific expression profiling of both known and novel long noncoding RNAs (LncRNAs) in the rodent DRG after nerve injury. We have identified a large number of novel LncRNAs expressed within the rodent DRG, a minority of which were syntenically conserved between the mouse, rat, and human, and including, both intergenic and antisense LncRNAs. We have also identified neuron type–specific LncRNAs in the mouse DRG and LncRNAs that are expressed in human IPS cell–derived sensory neurons. We show significant plasticity in LncRNA expression after nerve injury, which in mice is strain and gender dependent. This resource is publicly available and will aid future studies of DRG neuron identity and the transcriptional landscape in both the naive and injured DRG. We present our work regarding novel antisense and intergenic LncRNAs as an online searchable database, accessible from PainNetworks (http://www.painnetworks.org/). We have also integrated all annotated gene expression data in PainNetworks, so they can be examined in the context of their protein interactions.