bluuebunny/crossref_metadata_2025_split huggingface dataset:
Having more resilience factors only gets you so far in the context of neighborhood disadvantage: understanding differential predictors of internalizing symptoms and body mass index in youth with spina bifida
Authors: Scott Samantha Ruby , Peterson Robin L , North Samantha J , Merrick Jillian Sari , Petranovich Christine L , Wilson Pamela E , Lantagne Ann , Simpson Tess S 
Published: December 2024

Abstract

Objective
The primary aim of this study was to determine if neighborhood disadvantage predicted internalizing symptoms and body mass index (BMI) in youth with spina bifida (SB), while accounting for several sociodemographic factors. We also explored whether resilience factors helped explain associations between neighborhood disadvantage and internalizing symptoms or neighborhood disadvantage and BMI.

Methods
Participants (n = 69, Mage=14.13, Range: 8–20, 51% biological female, 25% Hispanic/Latinx White, 28% Other/Multiracial, 48% non-Hispanic/Latinx White) were drawn from a retrospective chart review of clinical data, including self-reported resilience factors and internalizing symptoms, collected as part of the standard of care in a multidisciplinary pediatric SB clinic. Neighborhood disadvantage scores were extracted from participant addresses. Using structural equation modeling, we examined whether neighborhood disadvantage predicted BMI and internalizing symptoms. We explored whether these paths were mediated by resilience factors.

Results
Higher neighborhood disadvantage predicted higher BMI and lower internalizing symptoms. Higher neighborhood disadvantage predicted higher resilience factors, which predicted lower internalizing symptoms. Higher resilience factors did not predict BMI.

Conclusions
Neighborhood disadvantage may require youth with SB to navigate their way to additional resilience factors to maintain better psychosocial outcomes. However, having more resilience factors may not help offset the physical health costs of disadvantaged neighborhoods.
(019) SEXUAL HISTORY-TAKING BY TUNISIAN PRIMARY HEALTHCARE PROVIDERS AND PATIENT-RELATED INFLUENCING FACTORS
Authors: Emna M , Kaabia O , Mohamed Hichem S , Ben Hassine SA , Cherif W , Cheour M 
Published: December 2024

Abstract

Introduction
Sexual history-taking is a crucial aspect of comprehensive healthcare. Understanding the dynamic of this interaction between primary health care providers and patients is important for improving the quality and depth of sexual history discussions.

Objective
We aim to explore the landscape of sexual history-taking practices among Tunisian family physicians and the various patient-related factors influencing them. By identifying barriers and facilitators, we can promote better patient-provider communication, ultimately enhancing the delivery of sexual healthcare services.

Methods
We conducted this cross-sectional study among Tunisian family medicine physicians and residents, using an anonymous online self-administered questionnaire in French.

Results
The study involved 400 participants, predominantly female (72.1%). It included general practitioners (40.8%), family medicine residents (38.2%), and physicians (21%). In our survey, 81.3% of participants indicated infrequent collection of patients’ sexual histories. Such inquiries occurred primarily when the chief complaint was urogenital (80%). According to participants, their approach was significantly influenced by patient’s gender (25.4%) and age, especially for patients under 18 and over 65, 59.7% and 45.4%, respectively, perceived a substantial impact on sexual history-taking. The educational level of patients significantly influenced this discussion according to 63.1%. The marital status was a considerable factor when taking sexual history according to 28% of participants. Patients’ religious contexts greatly influenced 29% of physicians. Sexual orientation significantly impacted discussions for 17.7% of participants, while 70% believed it had little or no impact. With People living with HIV, Men who have Sex with Men, Transgender individuals, Sex Workers, Injectable Drug Users, more than 20% of respondents declared experiencing “a lot” or “a tremendous amount” of difficulty addressing sexuality. Regarding medical conditions, chronic neuropsychiatric conditions were identified as a significant barrier by 42.6% of the respondents, surpassing motor or sensory impairments (22.3%).

Conclusions
Results shed light on the complexities surrounding sexual history-taking among Tunisian primary physicians. Participants revealed that their approach is significantly influenced by patients’ demographics and medical conditions. Challenges arise when addressing sexual health with key populations. These findings support the need for interventions to enhance healthcare professionals’ skills and comfort levels in addressing sexual health, ensuring a more comprehensive and inclusive care.

Disclosure
No.
(027) THERAPEUTIC EFFICACY OF HUMAN AMNIOTIC FLUID-DERIVED STEM CELLS IN RESTORING ERECTILE FUNCTION FOLLOWING CAVERNOUS NERVE-SPARING PROSTATECTOMY: EVIDENCE FROM A PROSTATE REMOVING-ERECTILE DYSFUNCTION RAT MODEL
Authors: Tsai W , Wu Y , Hsu W , Chiang H 
Published: December 2024

Abstract

Introduction
Erectile dysfunction (ED) after Nerve-sparing radical prostatectomy (NSRP) is a major concern for prostate cancer patient at far. The therapeutic potential of human amniotic fluid-derived stem cells (hAFSCs) in the treatment of ED is promising, but not fully understood.

Objective
Since cavernous nerve-sparing prostatectomy (CNSP)-ED is best animal model which mimic the ED caused by NSRP, In the CNSP injury rat paradigm, we aimed to determine the effect of application of hAFSCs after prostate removed without nerve injury and their effects on erectile function (EF) preservation.

Methods
We divided 24 number of 8-week-old Sprague–Dawley rats into three groups: sham (Group 1), saline intracavernosal (IC) injection after CNSP (Group 2), and hAFSC IC injection after CNSP (Group 3). hAFSCs from the fourth passage had the potential to differentiate into trilineage cells. All animals underwent EF analysis on the 28th day post-injection. To assess EF, we measured the mean arterial pressure (MAP) and intracavernosal pressure (ICP) in response to cavernous nerve (CN) stimulation. We also harvested the penis and major pelvic ganglion (MPG) for immunohistochemical and electron microscopy analyses.

Results
The rats treated with hAFSCs showed significantly higher ICP responses (the ratio of maximum ICP to MAP was 0.57 ± 0.04) than the CNSP rats (the ratio of maximum ICP to MAP was 0.38 ± 0.05). Immunohistochemical analysis revealed increased expression of α-SMA and vWf in the corpus cavernosum and enhanced expression of nNOS in the dorsal penile nerve (DPN) (p &lt; 0.05) and MPG of CNSP-ED rats. Electron microscopy revealed unmyelinated axonal reconstruction of CN and maintained corporal smooth muscle structures in CNSP-ED rats treated with hAFSCs.

Conclusions
hAFSCs treatment preserved EF in CNSP-ED rats at a single dose. The results of this study show the potential of hAFSCs as a novel application in the treatment of ED after prostatectomy.

Disclosure
No.
(028) SAFETY AND EFFICACY ASSESSMENT OF THE VERTICA® - A RADIO FREQUENCY DEVICE FOR THE TREATMENT OF ERECTILE DYSFUNCTION (ED)
Authors: Abou Chawareb E , Lumbiganon S , Hammad M , Miller J , Raheem O , Reisman Y , Gruenwald I , Lischinsky D , Yafi F 
Published: December 2024

Abstract

Introduction
The VERTICA® is a hand-held, home use device, designed to treat “mild to moderate” and moderate erectile dysfunction (ED) using radiofrequency (RF) electrodes. These electrodes deliver sequential RF energy to the penile area, with additional electrodes on a pad applied to the perineal area to also cover the penile crus. We hypothesize that 1) RF energy raises penile temperature, enhancing erectile response, and 2) RF energy posits a direct structural and biochemical impact on tunical and corporal tissue, improving the tunical veno-occlusive mechanism.

Objective
The purpose of the current study is to evaluate the safety and efficacy of the VERTICA® investigational device for treatment of ED.

Methods
This study is a pivotal, prospective, randomized, controlled, double-blind clinical trial. Around 100, in our center 33 adult, heterosexual, and sexually active males (≥22 years) with mild to moderate and mild organic ED (IIEF EF score 11-21) will be enrolled and randomized 1:1 for Active or Sham VERTICA® treatment. Patients are instructed to use the device 3 times a week for 4 weeks (12 treatments), twice a week for an additional 4 weeks (8 treatments) and then 1-2 times a week for another 4 months. Every treatment comprises a 15-minute session involving ring electrodes, followed by an additional 15-minute session incorporating both ring and pad electrodes. Compliance and treatment data is monitored using a smartphone app. Subjects are instructed to attempt sexual activity weekly or 6 times a month, logging events in the Sexual Encounter Profile (SEP) form. Monthly follow-up assessments at months 1, 2, 3, and 6 include evaluating the efficacy of the treatment using the IIEF-EF, SEP, EHS, EDITS, and SHIM questionnaires. Enhancements in ED will be measured by comparing the scores of these questionnaires within both groups and, for every individual, before and after completing the study.

Results
A pilot study with 28 subjects demonstrated the device’s safety and efficacy, with no serious adverse events reported in 144 treatment sessions.

Conclusions
In conclusion, the VERTICA® investigational device shows promise in the treatment of mild to moderate erectile dysfunction (ED) based on the pilot study and the ongoing pivotal clinical trial. If the results of this trial are promising, the VERTICA® device could offer a novel and effective treatment option for men with mild to moderate ED, potentially improving their quality of life and sexual health.

Disclosure
Yes, this is sponsored by industry/sponsor: OhhMed.
Clarification: Industry funding only - investigator initiated and executed study.
Any of the authors act as a consultant, employee or shareholder of an industry for: Sprout.
(047) SEXUAL HEALTH AMONG WOMEN WITH THYROID DISORDERS
Authors: Kaabia O , Gharbi I , Smaali H , Guefrech O , Maya Bahri Y 
Published: December 2024

Abstract

Introduction
Thyroid disorders are one of the most common endocrine disorders worldwide. Thyroid disorders are known to impact the patients’ quality of life and their sexual health and function, especially among women.

Objective
This study aims to assess any association between sexual dysfunction and thyroid disorders.

Methods
This is a nested case–control study where the cases were women self-reporting thyroid disorder and controls were self-reported healthy women matching for medical history, age, and relationship status. Data was collected through an online self-administered questionnaire. The sexual function was assessed through validated translations of the Female Sexual Function Index. Female sexual dysfunction is defined by an FSFI score ≤ 26.55.

Results
This study included 15 women with thyroid disorders and 30 controls. Age and other main socio-demographic components were similar between the 2 groups. The prevalence of female sexual dysfunction among thyroid disorder patients was 33.33% compared to 56.66% in the controls. (p = 0.20). There was no statistical difference between both groups in terms of total FSFI score (p = 0.34). There was also no difference between the groups among the six FSFI domains’ scores (Desire, Orgasm, Excitation, Lubrication, Pain, and Satisfaction).

Conclusions
This case–control study shows no difference in terms of sexual function between women self-reporting thyroid disorders and healthy young women. Although the literature may claim that thyroid disorders might be associated with altered sexual health among women, our population was under treatment at the time of the study, and thyroid hormonal treatment may have interacted with patients’ sexuality.

Disclosure
No.
(054) CAN WE IMPROVE TIME TO PATENCY WITH VASOEPIDIDYMOSTOMY WITH AN INNOVATIVE EPIDIDYMAL OCCLUSION STITCH?
Authors: Costantini Mesquita F , Savio LF , Velasquez DA , Aponte Varnum A , Barros R , Miller D , Petrella F , Ramasamy R 
Published: December 2024

Abstract

Introduction
Obstructive azoospermia, affecting 40% of azoospermia cases, occurs when a blockage in the male reproductive tract leads to no sperm in the ejaculate. Blockages may be congenital or acquired, affecting the epididymis, vas deferens, or ejaculatory ducts. Congenital causes include conditions like congenital bilateral absence of the vas deferens, while acquired causes involve vasectomy, infections, trauma, or medical procedures. Treatment includes microsurgical reconstruction or sperm extraction for IVF, with microsurgery being cost-effective. Success rates are 99% for vasovasostomy (VV) but drop to 65% for vasoepididymostomy (VE). Refinement of VE techniques is crucial for improving outcomes.

Objective
A 39-year-old male with obstructive azoospermia underwent VE. His partner, 37, has regular menstrual cycles. Clinical data included FSH levels, semen analysis, and testicular sperm aspiration results.

Methods
The procedure began with the right vas deferens. A vasogram showed no obstruction. No fluid from the testicular side led to VE. Dilated epididymal tubules were identified, and motile sperm was found. A novel epididymal occlusion stitch was applied to enhance sperm passage through the anastomosis. The steps were repeated on the left. At a 3-month follow-up, the patient had motile sperm in his semen analysis.

Results
The epididymal occlusion stitch aims to improve VE success. The 3-month follow-up showed promising results with motile sperm presence. Historical success rates for VE have remained low with delayed patency and higher failure rates. Enhancements in VE techniques are needed to improve outcomes.

Conclusions
This video highlights a novel technique to improve VE success rates. The epididymal occlusion stitch shows promise in reducing patency time and enhancing outcomes, marking progress in male reproductive surgery.

Disclosure
No.
(062) BIPOLAR ELECTROSURGICAL SCISSORS IN OPEN ANDRO-SURGERY. THE HUNT FOR HEMOSTASIS AND HASTE
Authors: Mahmoud O 
Published: December 2024

Abstract

Introduction
Controlling hemostasis is a main part of any surgery, and can be time consuming in some. Electro-surgical cautery is a fundamental way to control bleeding. Bipolar electro-cautery limits tissue devitalization by limiting energy spread. Bipolar Scissors (BPS) combine scissor-cutting process and bipolar diathermy in one instrument and one surgical step. Preserving tissue viability and a short operative time improve surgical outcome.

Objective
To study the outcome of using BPS in inflatable penile prosthesis (IPP), Shaeer’s corporal rotation for correction of severe ventral penile curvature (SCR) and suprapubic dermo-lipectomy (DL) for revealing the concealed penis.

Methods
The BPS group was compared to a control group where BPS was not utilized. BPS were used to cut through Dartos and Buck’s fascia, mobilize the neurovascular bundle and excise suprapubic fat. Operative time and drain output were evaluated.

Results
Mean operative time was significantly shorter in BPS group by 13.6% for IPP surgery, 18.7% for SCR and 23.6% for DL. Mean drain output was significantly less in BPS group by 50.5% in IPP and 35.4% in DL. Peno-scrotal edema was less pronounced and resolved faster when BPS was used.

Conclusions
Bipolar scissors offer better hemostasis and a shorter operative time in penile prosthesis, penile curvature and pubic lipectomy surgeries.

Disclosure
No.
(064) A NOVEL SURGICAL TECHNIQUE TO FACILITATE FEMALE ORGASM
Authors: Unal C , Aydin S 
Published: December 2024

Abstract

Introduction
Female orgasmic disorder is defined as marked infrequency or absence of orgasm and the distress caused by the situation. The approach to treatment is based on psychosocial treatment models. Directed masturbation, sensate focus exercises, exposure and cognitive behavioral therapy are the psychosocial treatment options defined. Surgical reconstruction and adjustment or cosmetic surgery serve as a different yet limited way for treatment. The evidence shows that the clitoral anatomic topography may affect female sexual function; longer the clitoro-urethral distance was found to be correlated with lower Female Sexual Function Index (FSFI) Orgasm sub scores.

Objective
We aim to introduce a surgical technique, to be performed to women whose clitoro-urethral distance is more than 25 millimeters and having difficulty in reaching orgasm.

Methods
The medial faces of the labia minora are planned to be partially excised by drawing rhomboid figures on both sides. Horizontal wound closure was performed via separated suturing technique with 3.0 absorbable monofilament suture. After the clitoro-uretral distance reduction, a crescent incision was performed superficial to clitoris. Separated suturing technique with 3.0 absorbable monofilament suture was preferred for wound closure. Perineal tear due to vaginal delivery was reconstructed by routine colporrhaphy posterior.

Results
Patient with the complaint of having difficulty in reaching orgasm was evaluated, she had no medical history apart from a vaginal delivery in 2019. She has been sexually active for 8 years and 4 years ago she had cognitive behavioral therapy. The findings were rectocele grade 3 and the distance between the clitoris and urethra was found to be 25 millimeters. Preoperative FSFI score was found to be 17.6, with a remarkable orgasm sub score showing 2. Colporrhaphy posterior, clitoro-urethral distance reduction and clitoral hood reduction was performed. Postoperative healing period was uneventful. Postoperative sixth month FSFI score was 25.8 with an orgasm sub score 4.2.

Conclusions
Surgical approach the female orgasmic disorder is not the first line approach, however in a chosen group of patients with a clitoral urethral distance longer 25 millimeters, the reduction procedure may serve as an option.

Disclosure
No.
(085) THE PATIENT-PERCEIVED INTRAVAGINAL EJACULATION LATENCY TIME CUT-OFF FOR LIFELONG PREMATURE EJACULATION
Authors: Wang C , Zhong Q , Colonnello E , Xi Y , Sansone A , Zhang H , Chen Q , Jannini EA , Zhang Y 
Published: December 2024

Abstract

Introduction
The current cutoff values of IELT for diagnosing lifelong premature ejaculation (LPE) do not always match clinical practice, and the inconsistency in the cutoff values of IELT among different definitions has also posed challenges to both clinical management and research of PE.

Objective
To re-evaluate the IELT and to find evidence-based cut-off values for diagnosing LPE that can be widely accepted and match clinical practice.

Methods
We addressed the flaws of previous studies. LPE was diagnosed based on both patient self-report of PE status and scores on the Premature Ejaculation Diagnostic Tool (PEDT), with a control group consisting of non-PE individuals included for comparison. Utilizing receiver operating characteristic (ROC) curve analysis, the optimal self-estimated cutoff value for IELT in diagnosing LPE was determined.

Results
A total of 307 heterosexual participants (mean age = 30.7 ± 6.4) were included, comprising 187 LPE patients (mean age = 28.0 ± 4.6) and 120 non-PE individuals (mean age = 35.0 ± 6.5). 2.7% of LPE patients experienced anteportal ejaculation. 59.9%, 92%, and 97.9% of LPE patients displayed IELTs within 1, 2, and 3 minutes, respectively. The ROC curve’s AUC was 0.996 with a 95% CI of 0.991–1.000 (p &lt; 0.0001). The P-IELT cut-off at 3.5 (sensitivity = 97.9%, specificity = 99.2%) showed the highest Youden index compared with other options.

Conclusions
The P-IELT cutoff value for diagnosing LPE within a clinical practice context is 3.5 minutes.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: EAJ is or has been paid consultant and/or paid speaker for Bayer, Ibsa, Menarini, Otsuka, Pfizer, Viatris.
(098) DOES METABOLIC SYNDROME HEIGHTEN THE RISK OF SEXUAL DYSFUNCTION IN BOTH MEN AND WOMEN?
Authors: Dilixiati D , Lu J , Kadier K , Chen F , Qiao B , Ge C , Zebibula A , Rexiati M 
Published: December 2024

Abstract

Introduction
Previous research has examined the link between Metabolic Syndrome (MetS) and male sexual dysfunction. However, there is limited and conflicting evidence regarding MetS and Female Sexual Dysfunction (FSD).

Objective
We investigated the correlation between MetS and both ED and FSD through two-sample Mendelian randomization(MR) and meta-analysis methods, respectively.

Methods
A two-sample MR study was conducted to investigate the causal relationship between MetS and its five individual components (hypertension, waist circumference (WC), fasting blood glucose (FBG), triglycerides, and high-density lipoprotein cholesterol (HDL-C)) and ED. In addition, a systematic search of four databases (the PubMed, Scopus, Embase and Cochrane Library databases) was conducted from inception to 23 August, 2023.

Results
In MR study, our observation revealed that hypertension (OR = 1.104, 95% CI: 1.014 − 1.202, p = 0.023) and WC (OR: 1.279, 95% CI = 1.101-1.486, P = 0.001) exhibited an increased genetic predisposition to ED. However, no causal effects of MetS, FBG, triglycerides and HDL-C on ED were observed in our study. The results of the meta-analysis showed a significant 1.746-fold increased risk of FSD in individuals with MetS compared to the control group (OR = 1.746, 95% CI = 1.359–2.241, P &lt; 0.001).

Conclusions
Our study provides genetic evidence supporting the causal relationship between hypertension, WC and ED, rather than MetS itself, FBG, triglycerides, or HDL-C. In addition, our systematic review and meta-analysis results suggest that patients with MetS have a significantly increased risk of FSD.

Disclosure
No.