bluuebunny/crossref_metadata_2025_split huggingface dataset:
NEOVASCULAR GLAUCOMA AS A PREDICTOR OF RETINOBLASTOMA HIGH-RISK HISTOPATHOLOGY IN AN INTERNATIONAL MULTICENTER STUDY
Authors: Negretti Guy S. , Ushakova Tatiana , Yuri Serov , Vladimir Polyakov , Berry Jesse L. , Pike Sarah , Shields Carol L. , Hubbard G. Baker , Eiger-Moscovich Maya , Pe'er Jacob , Staffieri Sandra E. , Elder James E. , McKenzie John D. , Ahmad Alia , Hussain Mahvish , Casavilca-Zambrano Sandro , Alarcon-Leon Sandra , Yousef Yacoub A. , Mohammad Mona , Tanabe Mika , Arazi Mattan , Fabian Ido Didi , Goldstein Samuel , Kaliki Swathi , Sagoo Mandeep S. , Reddy M. Ashwin 
Published: December 2024

Purpose:
To assess histopathology and outcomes after primary enucleation of eyes with retinoblastoma presenting with neovascular glaucoma (NVG).

Methods:
This was an international multicenter case series study across five continents. A retrospective review of patient charts was performed for all patients undergoing primary enucleation for retinoblastoma (n = 1,420) using a standardized data-collection spreadsheet. Clinical features, pathologic grade, and outcomes were compared between NVG patients and those with an American Joint Commission on Cancer eighth edition clinical stage of cT2. High-risk histopathology was defined as American Joint Commission on Cancer eighth edition pathologic stage ≥ pT2b.

Results:
Neovascular glaucoma was seen in 224/1,420 (16%) patients. The mean age at presentation of those with NVG was 30 months (median 25, range 0–120 months), and 131 (58%) patients had high-risk histopathology. The univariate logistic regression odds ratio for NVG predicting high-risk histopathology was 1.73 (95% confidence interval: 1.3–2.31) and from multivariate logistic regression was 1.77 (95% confidence interval: 1.23–2.56). Patients with a longer duration of symptoms (P = 0.03), buphthalmos (P = 0.02), and ectropion uveae (P < 0.01) were more likely to have high-risk histopathology. Patients with NVG were more likely to develop metastasis than cT2 patients (P = 0.04).

Conclusion:
There is a significant association between NVG at presentation, high-risk histopathology, and metastatic risk.
SOMATOSTATIN ANALOGUES VS ACTIVE SURVEILLANCE IN SMALL PANCREATIC NEUROENDOCRINE TUMORS
Authors: Maratta Maria Grazia , Chiloiro Sabrina , Raia Salvatore , Maiorano Brigida A. , Horn Guido , Brizi Maria Gabriella , Rufini Vittoria , Giancipoli Romina Grazia , De Marinis Laura , Bianchi Antonio , Pontecorvi Alfredo , Schinzari Giovanni , Inzani Frediano , Tortora Giampaolo , Rindi Guido 
Published: December 2024

ABSTRACT

Objectives
The best strategy for non-functioning, sporadic, G1-G2 pancreatic neuroendocrine tumors ≤2 cm is unknown. An active surveillance is usually recommended. The PROMID and the CLARINET studies proved the value of somatostatin analogue (SSA) treatment in advanced gastro-entero-pancreatic neuroendocrine tumors. Aim of this study is to assess the value of SSA in PanNET≤2 cm.

Methods
We retrospectively collected data from 72 patients with sporadic non-functioning G1-G2 PanNETs≤2 cm, that were either treated with somatostatin analogues (n = 31) or underwent active surveillance (n = 41) at our Institution.

Results
At a median follow-up of 53.7 months, the median progression free survival was not reached in the treatment group versus an estimated PFS of 85 months in the control group (HR 0.11, p = 0.01), with a rate of progression or death up to 21.9% in the active surveillance group. Additionally, in the group of patients treated with somatostatin analogues the response rate was 16.1% with one complete response.

Conclusions
Our monocentric experience demonstrated a significant antiproliferative activity of somatostatin analogues in patients with sporadic, non-functionating G1-G2 PanNETs ≤2 cm delaying tumor progression and distant spread in small lesions that sometimes may reveal unpredictable aggressiveness.
Phase II randomized controlled trial to evaluate the supportive effect of Koujin (TJ-3020) powder in gemcitabine and nab-paclitaxel-treated unresectable or recurrent pancreatic cancer
Authors: Otsu Tomohisa , Takami Hideki , Yamada Suguru , Nakatochi Masahiro , Fujita Keizo , Tashiro Mitsuru , Hayashi Masamichi , Nakagawa Nobuhiko , Kurimoto Keisuke , Tanaka Haruyoshi , Kinoshita Fumie , Kuwatsuka Yachiyo , Kodera Yasuhiro 
Published: December 2024

Abstract

Objectives
Gemcitabine and nab-paclitaxel combination therapy (GnP) is a standard treatment for unresectable or recurrent pancreatic cancer. However, fatigue and malaise are frequent adverse effects. Recently, Kampo medicine containing ginsenoside has been reported to relieve cancer-related fatigue. Therefore, in this randomized trial, we used red ginseng powder (Koujin, TJ-3020), which contains ginsenoside, to evaluate its effect on unresectable or recurrent pancreatic cancer treatment.

Methods
From December 2017 to December 2020, we enrolled 40 pancreatic cancer patients. The patients underwent two cycles of GnP for unresectable cancer or postoperative recurrence. The patients were randomized into group A (red ginseng powder administration) or group B (no red ginseng). In group A, 0.67 g of red ginseng powder was taken orally three times a day before each meal for 56 days of the planned chemotherapy period. The Cancer Fatigue Scale evaluated physical, mental, cognitive, and comprehensive fatigue over time.

Results
The patients’ backgrounds, including age, sex, pancreatic cancer status, and relative dose intensity of the GnP chemotherapy, did not differ between groups A and B. Cases with abnormal CA19-9 were frequently assigned to group A. None of the Cancer Fatigue Scale fatigue scores differed significantly between the groups. Mental fatigue score was significantly higher in patients aged ≥70 years (odds ratio: 4.57; P = 0.033), and recurrent pancreatic cancer status tended to influence all fatigue scores. However, no other critical factor significantly affected the physical, cognitive, and comprehensive fatigue scores.

Conclusions
In this phase II randomized trial, oral administration of red ginseng powder at 2.0 g per day did not reduce pancreatic cancer patients’ fatigue or malaise induced by GnP combination chemotherapy.
Maternal and Newborn Care for Ornithine Transcarbamylase Deficiency
Authors: Anderson Sharon 
Published: December 2024

Abstract
Ornithine transcarbamylase deficiency is the most common urea cycle disorder. If left untreated, pathogenic variants in the OTC gene can cause hyperammonemia leading to neurotoxicity, coma, and death. A comprehensive overview of ornithine transcarbamylase deficiency is presented including the genetic cause; varied age of onset, clinical presentation, and severity; diagnostic testing; and lifelong and anticipated future treatments. More specifically, there is a focus on the prenatal, natal, and postpartum course and treatment recommendations for genetic heterozygous (carrier) females and hemizygous male newborns with ornithine transcarbamylase deficiency.
Publication Pressure in Nuclear Medicine
Authors: Kwee Thomas C. , Aldub Ali , Kwee Robert M. 
Published: December 2024

Purpose
The aims of this study were to determine the publication pressure perceived by nuclear medicine scientists and to identify associated determinants.

Patients and Methods
Corresponding authors who published in Clinical Nuclear Medicine, Journal of Nuclear Medicine, or European Journal of Nuclear Medicine and Molecular Imaging between 2021 and 2023 were invited to participate in this survey study. Publication pressure was assessed using the revised Publication Pressure Questionnaire in the domains of “publication stress” (stress due to perceived pressure to publish), “publication attitude” (attitude regarding current publication culture), and “publication resources” (resources when working on publications or experiencing stress when working on publishing), with 5-point Likert scales.

Results
A total of 181 individuals participated. Median Publication Pressure Questionnaire scores in the domains “publication stress,” “publication attitude,” and “publication resources” were 3.33, 3.33, and 2.17, respectively. None of the researchers’ characteristics were significantly associated with publication stress. Age >65 years was significantly associated with a more positive view on the publication climate (β coefficient of −0.552, P = 0.007). Several variables were significantly associated with a perception of fewer factors available to alleviate publication pressure: age 45–54 years (β coefficient of 0.249, P = 0.030), age 55–64 years (β coefficient of 0.421, P = 0.002), associate professor position (β coefficient of 0.398, P < 0.001), fellow/resident position (β coefficient of 0.355, P = 0.007), <5 years of research experience (β coefficient of 0.410, P = 0.026), and 5–10 years of research experience (β coefficient of 0.361, P = 0.003).

Conclusions
Publication pressure among nuclear medicine scientists is appreciable. Several researcher characteristics appear to be associated with vulnerability to publication pressure.
Tabletop Simulations in Medical Emergencies
Authors: Frégeau Amélie , Vinette Billy , Lapierre Alexandra , Maheu-Cadotte Marc-André , Fontaine Guillaume , Castonguay Véronique , Flores-Soto Rodrigo , Garceau-Tremblay Zoé , Blais Samuel , Vigneault Laura-Philippe , Hansen-Jaumard Delphine , Laramée François , Iseppon Massimiliano , Daoust Raoul , Cossette Sylvie , Buyck Michael , Fleet Richard , Cournoyer Alexis 
Published: December 2024

Summary Statement
Tabletop simulations (TTS) are a novel educational modality used in health care education. The objective of this scoping review was to describe the use of TTS in medical emergencies, specifically settings, specialties, participants, formats, and outcomes.
We included 70 studies (33 descriptive studies [47%], 33 cohort studies [47%], and 2 randomized controlled trials [3%]), of which 65 reported positive results regarding reaction and learning educational outcomes (reaction: n = 37, 53%; learning: n = 25, 36%; behavior: n = 7, 10%; result: n = 1, 1%). The scenario for most TTS was a disaster (n = 56; 80%). Most TTS involved participants from several professions (n = 45; 64%). A board game was used in 26 studies (37%).
Most studies on TTS in medical emergencies involved participants from multiple professions addressing disaster scenarios and showed positive results pertaining to reaction or learning educational outcomes.
L-Asparaginase treatment induces reversible immunoregulatory and immunosuppressive effects in non-malignant B cells in a model of T-cell dependent B cell activation
Authors: Hadzic Amar , García-Márquez María Alejandra , Bannasch Pol , Haindl Nina , Frey Katharina , Kirmaier Martin , Funk Maximilian , Tischmacher Anneli , Tu Jingke , Carboniero Adriano , Vona Ludovica , Oganesian Sabine , Schlößer Hans , Schmitz Werner , von Bergwelt Michael , Cordas dos Santos David M. , Theurich Sebastian 
Published: December 2024

AbstractMetabolic reprogramming is critical for immune cell adaptation upon activation to exert full functionality with amino acids being a key metabolic factor. While L-asparagine is a non- essential amino acid it turns out to be conditionally essential in malignant B cells due to defective asparagine synthetase making L-asparaginase a commonly used chemotherapeutic agent. Off-target enzymatic activity including glutaminolysis impacting crucial immune function. However, its effects on healthy B cells remain unclear, therefore in this study, we explored how L-asparaginase modulates the biology and function of CD40-activated B cells, using an in-vitro model. B cells from healthy donors were treated with increasing L- asparaginase concentrations and analyzed for proliferation, immune phenotype, and metabolic changes. Results showed L-asparaginase reduced B cell proliferation and homotypic clustering without inducing apoptosis, instead impairing metabolic pathways, lowering glycolysis and oxidative phosphorylation, and reducing surface markers associated with antigen-presenting cell (APC) function. Functional assays confirmed that L-asparaginase- treated B cells had diminished ability to activate T cells. Supplementing with asparagine or glutamine restored B cell proliferation and function, with glutamine slightly more effective than asparagine. Interestingly, L-asparaginase induced a regulatory B cell phenotype, marked by CD24+CD38+CD27+ expression and increased interleukin-10 and TGF-beta, suggesting a potential immunosuppressive mechanism. These findings indicate that L-asparaginase not only affects malignant cells but also impacts the function of non-malignant B cells, proposing potential therapeutic applications in B cell-driven autoimmune disorders. Further studies are needed to explore its effects at lower, clinically relevant concentrations.Abstract Figure
The Regulation of MAGI2 and its Diagnostic Application in Podocytopathies
Authors: Siegerist Florian , Hay Eleonora , Hammer Elke , Iervolino Anna , Weber Claudia , Dikou Juan Saydou , Stamellou Eleni , Butt Linus , Benzing Thomas , Wiech Thorsten , Brinkötter Paul T. , Zimmerman Uwe , Capasso Giovambattista , Chatziantoniou Christos , Chadjichristos Christos , Huber Tobias B. , Völker Uwe , Schindler Maximilian , Endlich Nicole 
Published: December 2024

AbstractPodocyte dysfunction is central to various glomerular diseases, necessitating reliable biomarkers for early detection and diagnosis. This study investigates the regulatory mechanisms of membrane-associated guanylate kinase inverted 2 (MAGI2) and its potential as a biomarker for podocytopathies. The expression of the gene coding for the scaffolding protein MAGI2 was examined across four species and demonstrated to be conserved within the podocyte filtration slit.In vitroandin vivostudies using isolated glomeruli and mammalian animal models of glomerular disease, including DOCA-salt hypertension, nephrotoxic serum nephritis, and puromycin aminonucleoside nephropathy, demonstrated significant downregulation of MAGI2 in injured podocytes. This downregulation was also conserved in a zebrafish model of focal and segmental glomerulosclerosis (FSGS), and the podocyte-specific MAGI2 ortholog Magi2a was reduced post podocyte injury. CRISPR/Cas9-generated zebrafish mutants formagi2aexhibited marked glomerular filtration barrier defects and downregulation of nephrin, underscoring MAGI2’s critical role in podocyte function.Human biopsy analyses revealed differential MAGI2 expression: it was increased in minimal change disease (MCD) patients but significantly decreased in primary, but not secondary FSGS cases. As MAGI2 localization did not change in disease states it is an alternative marker for super-resolution microscopy-based morphometry of the filtration slit, correlating with nephrin-based measurements.These findings highlight the potential of MAGI2 as a sensitive biomarker for podocyte injury and its diagnostic utility in differentiating between primary FSGS and MCD.
A simplified risk model for pretreatment stratification of newly diagnosed acute myeloid leukemia patients treated with venetoclax and azacitidine
Authors: Islam Nazmul , Reuben Jamie S. , Dale Justin L. , Zhang Jingjing , Coates James W. , Sapiah Karan , Markson Frank R. , Wu Lezhou , Kulkarni Ujjwal V. , Boyiadzis Michael , Smith Clayton A. 
Published: December 2024

AbstractVenetoclax plus azacitidine (ven/aza) is a new standard of care for adult Acute Myeloid Leukemia (AML) patients who are not candidates for intensive therapies. Risk stratification approaches have been proposed to identify patients with favorable, intermediate, and adverse therapeutic outcomes following ven/aza and other lower intensive therapies. However, most have been developed for retrospective data analyses and have limitations in their application to upfront risk stratification of newly diagnosed patients. Here, we describe an AML risk model, termed the Refined Risk Model (RRM), that is specific for ven/aza, addresses important real-world considerations and utilizes pathology features that have the potential to be available relatively quickly-and-broadly following diagnosis. The RRM was developed and internally validated using a single center cohort of 316 AML patients from the University of Colorado treated upfront with ven/aza, and then externally validated on an AML cohort from a nationwide electronic health record-derived de-identified AML database. The RRM effectively stratified patients into Adverse, Intermediate, and Favorable groups across both the internal and external cohorts; it performed well in subsets with or without allogeneic transplant recipients, demonstrated tolerance to missing data, and showed numerical performance comparable to or exceeding the existing alternatives such as the European Leukemia Network (ELN 2022) and molecular prognostic risk signature (mPRS) models. These findings suggest that the RRM may have potential application in defining the prognostic mortality risk for newly diagnosed AML patients, which may help guide clinical trial design and execution as well as other important elements of AML clinical decision support.
Digital innovation in software SMEs: the synergy of digital entrepreneurship opportunities, knowledge generation and market-sensing capabilities via moderated–mediation approach
Authors: Zhang Jianhua , Sherani  , Riaz Muhammad , Zia Umair , Ali Sher , Liu Jinyan 
Published: December 2024

PurposeThis study drawing upon opportunity-ability-motivation (OAM) theory focuses on digital entrepreneurship opportunities (DEOs), knowledge generation capabilities (EKGCs) and enterprise market-sensing capabilities (EMSC) affecting digital innovation in terms of exploitative and exploratory DIs.Design/methodology/approachEmploying quantitative methodology on a sample of 352 software SMEs' managers, the study employed a hierarchical regression analysis to investigate whether and how digital entrepreneurship opportunities and knowledge generation capabilities support and nurture both DIs. Additionally, the moderated–mediation effect of market-sensing capabilities on the relationships among digital entrepreneurship opportunities, enterprise knowledge generation capabilities and DIs are considered.FindingsThe study findings reveal that digital entrepreneurship opportunities influence exploitative and exploratory DIs. Knowledge generation capabilities partially mediate the relationship between digital entrepreneurship opportunities and exploitative and exploratory DIs, respectively. Moreover, market-sensing capabilities strengthen not only the effect of digital entrepreneurship opportunities on knowledge generation capabilities but also the effects of knowledge generation capabilities on exploratory DI. The moderated–mediation outcomes reveal that the mediating role of knowledge generation capabilities on the relationship between digital entrepreneurship opportunities and both DIs is stronger when EMSC are high.Originality/valueThis research integrates the opportunity-ability-motivation perspective to present a comprehensive framework that reveals the intricate interdependencies among digital entrepreneurship opportunity, knowledge generation and market-sensing capabilities in driving both exploratory and exploitative digital innovation in software SMEs. This approach significantly enhances our understanding of how software SMEs can strategically strengthen their internal skills and resources, ultimately leading to superior digital innovation outcomes.
Enhancing corporate resilience: the impact of female board representation on financial distress in Jordanian companies
Authors: Alhaddad Lara , Gerged Ali Meftah , Gharaibeh Mohammad , Saidat Zaid , Aziz Tariq 
Published: December 2024

Purpose
This paper aims to examine the impact of board gender diversity on the likelihood of financial distress in 90 Jordanian companies listed on the Amman Stock Exchange from 2010 to 2021.

Design/methodology/approach
To examine the hypotheses, this study used the panel logistic regression. In addition, this study used the two-staged Heckman regression model as a robust check. To proxy for the financial distress, the 2005 version of Altman’s Z-score for emerging markets was used.

Findings
The results indicate that female directors can reduce the likelihood of financial distress in Jordanian listed companies. These findings align with previous literature that highlights the benefits of female directors on corporate boards.

Originality/value
To the best of the authors’ knowledge, this study is the first to examine the impact of board gender diversity on financial distress in Jordan and the Middle East and highlights several practical implications. It emphasizes the need for policymakers to develop regulations that promote gender diversity on corporate boards as a strategy to enhance stability and prevent financial distress. For corporate managers, incorporating more women into board roles could strengthen decision-making and risk management. Regulators are advised to support these changes through improved governance codes. In addition, increasing female board participation could enhance corporate responsibility, reduce bankruptcy risks and boost overall economic stability, benefiting society at large.
The impact of corporate social responsibility on green innovation: a test based on meta-analysis
Authors: Wang Haihua , Li Shujie , Gong Yanyan , Wang Ying 
Published: December 2024

Purpose
This study aims to investigate the impact of corporate social responsibility (CSR) on green innovation by considering the three dimensions of green innovation cognition, behavior and outcomes and to explore the role of situational and measurement factors in this relationship.

Design/methodology/approach
This study adopts a meta-analysis method to integrate 208,997 observations from 48 independent empirical studies on CSR and green innovation.

Findings
CSR positively affects green innovation cognition, behavior and outcomes. Additionally, the relationship between CSR and green innovation is stronger in Western cultural background than in Eastern ones. The impact of CSR on green innovation is also more significant in small and medium-sized enterprises (SMEs). Moreover, this study shows that the correlation between CSR and green innovation is stronger when the source of data is primary data and when green innovation is measured by non-patent methodologies.

Originality/value
This study elucidates the impact of CSR on green innovation and further clarifies the potential reasons for the divergent findings in existing related studies. The article enriches the theoretical results related to CSR and green innovation and provides valuable insights and references for corporate decision-makers.
Unravelling the complexities of carnivals: potentials and challenges for social change in Mexico
Authors: Monterrubio Carlos , Dashper Katherine 
Published: December 2024

PurposeThis research aimed to explore the complexity of the carnival as a space that both challenges and reinforces social hierarchies, as well as a potential catalyst for social transformation for marginalised groups.Design/methodology/approachParticipant observations were carried out at various carnival sites, with a particular emphasis on the “Carnaval de Ixtapan” in Central Mexico in 2024. These observations were supported by photographs and videos.FindingsThe carnival’s transgressive nature has led to progress in inclusivity, notably by featuring women and LGBTQ + individuals in prominent roles, thereby shifting gender and heteronormative dynamics. However, it remains predominantly male-dominated, hindering change and reinforcing existing power dynamics. While cross-dressing challenges societal norms, it can also inadvertently reinforce male supremacy, and LGBTQ + individuals often encounter resistance to their participation. Despite these challenges, the carnival’s temporary, spatial, and purposeful nature provides a platform for social change, offering visibility to marginalised groups and facilitating dialogue on diversity and inclusion.Originality/valueThis study provides rich insight into the ways in which carnival can be a mechanism for both reinforcing and challenging social norms in Latin America.