bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood Assets and Cardiometabolic Health in Adolescence
Authors: Qureshi Farah , Koenen Karestan C. , Tiemeier Henning , Williams Michelle A. , Misra Supriya , Kubzansky Laura D. 
Published: February 2019

BACKGROUND:
Research shows that the development of cardiometabolic disease can begin early in life with risk factors accumulating over time, but less is known about protective pathways to positive health. In this study, we use prospective data to test whether childhood assets predict a greater likelihood of being in optimal cardiometabolic health by age 17.

METHODS:
Data are from 3074 participants in the Avon Longitudinal Study of Parents and Children (mean age = 17.8). Four childhood assets were prospectively assessed via cognitive tests and parent report when children were between ages 8 and 10: strong executive functioning skills, prosocial behaviors, and low levels of internalizing and externalizing problems. Cardiometabolic health was assessed at ages 9 and 17 by using a composite dysregulation score derived from multiple biological parameters, including cholesterol, blood pressure, C-reactive protein, insulin resistance, and BMI. Associations between assets and optimal health at age 17 (ie, a dysregulation score of ≤1) were evaluated with Poisson regression models with robust error variances.

RESULTS:
After controlling for covariates (including sociodemographics, correlates of cardiometabolic health, and dysregulation scores at age 9), participants with multiple assets were 1.08 to 1.27 times more likely to be in optimal cardiometabolic health at age 17 compared with those with 0 or 1 asset. Each additional asset conferred a 6% greater likelihood of optimal health over time (relative risk = 1.06 [95% confidence interval: 1.01 to 1.11]).

CONCLUSIONS:
Childhood assets predicted cardiometabolic health with seemingly cumulative impacts. Identifying early assets may provide novel targets for prevention and elucidate pathways to positive adult health.
Oncourologist’s opinion on the results of the CARMENA study
Authors: Volkova M. I. 
Published: February 2019

Recently published results of CARMENA study seem to eliminate cytoreductive nephrectomy from current recommendations on the treatment of metastatic renal cell carcinoma patients who are candidates for targeted antiangiogenic therapy. The article is devoted to the critical analysis of the CARMENA trial and review of previously published data. Taking into account available data cytoreductive nephrectomy should be still performed in carefully selected patients.
Talon Cusp: Two Case Reports
Authors: BAYRAKTAR Yusuf , BAHADIR Sevilay 
Published: February 2019

The
talon is an accessory, irregular cusp on incisors and canines, involving in
enamel and dentine with or without pulp tissue.It was also reported in
association with syndromes, for example, Mohr Syndrome, Incontinenta pigmentii
Achromians, Ellis-van Creveld Syndrome, Struge Weber Syndrome, Rubinstein Taybi
Syndrome, and Alagille’s Syndrome. The aim of this paperwas to
describe talon tubercules in two cases. In first case the talon cusp is seen on
lingual surface of the maxillary left central tooth and there is a specific
talon tubercle which extending from the incisal edge to the cervical edge,
perpendicular to the mesiodistal surface of the tooth. In second case bilateral
talon tubercles were detected extending from the cervical region less than half
of the incisal margin on the lingual surface of the maxillary central and
lateral teeth. This present two case reports
radiograph gives a v-shaped radiopaque image.Talon tubercle is a dental
anomaly we rarely encounter. Consequently this anomaly may occur with a
systemic syndrome Therefore, clinicians should have adequate knowledge of this
anomaly.
Un regard qualitatif sur la motivation en grammaire d’élèves de la fin de l’ordre élémentaire scolarisés en contexte francophone minoritaire
Authors: Thibeault Joël , Fleuret Carole 
Published: February 2019

À partir de données provenant d’un questionnaire et d’une entrevue, cet article explore la motivation en grammaire de huit élèves de la fin de l’élémentaire en milieu minoritaire et la met en relation avec le développement de leur compétence à effectuer l’accord du verbe à l’écrit. Les résultats nous permettent de poser des hypothèses viables sur la relation entre la motivation en grammaire et le développement de ladite compétence. Ils révèlent aussi que, pour les élèves, le travail grammatical est fréquemment associé à la mémorisation de formes linguistiques et que celle-ci ne contribue pas à leur motivation.
Hidden Children: Using Children's Literature to Develop Understanding and Empathy Toward Children of Incarcerated Parents
Authors: Reimer Val Plett 
Published: February 2019

Abstract
Research indicates that children whose parents are incarcerated are a vulnerable group of people with poor life outcomes. Yet these children are not tracked in the Canadian system, making it difficult for schools to respond with appropriate supports. How can schools be inclusive to this hidden demographic of children? Framed in theories of Critical Literacy and Ethic of Care, the author proposes the use of story to develop understanding and empathy. Research shows that acknowledging these children’s experiences through story helps them to feel validated while broadening capacity for empathy among other children. Can a story develop empathy toward children of incarcerated parents? To answer this question, the author wrote a picture book about a child who visits her mother in jail, and read the story to three groups of children, interspersed and followed by rich discussions. The story elicited empathetic responses from all students, suggesting the benefits of this approach.
An Inquiry into Adolescents’ Experiences with Cognitively Demanding Writing: Time Investment and the Importance of Authenticity’
Authors: Mitton-Kukner Jennifer , Michael Heather 
Published: February 2019

In this paper, we describe our 12-month inquiry into understanding adolescents’ experiences, as they engaged in writing that challenged them to construct knowledge by making claims grounded in evidence and reasoning.While engaged in the task of writing a research paper, participants’ perceptions of time were two-fold in that they consistently identified a lack of time and a lack of understanding about the time the research paper demanded.We argue enabling students to have more temporal control over their writing is related to fostering increased metacognition about writing as a process.
The Effect of Comprehensive Rehabilitation Program plus Chemotherapy on Quality of Life of Patients with Postoperative Non-Small Cell Lung Cancer: A study protocol of multi-center randomized clinical trial
Authors: Yao JiaLin , Jiao Lijing , Lu Yan , Shi Jun , Li Jiaqi , Chen Peiqi , Xu Ling , Yao Yiqing , Gong Yabin 
Published: February 2019

Abstract
Background: Comprehensive rehabilitation therapy based on Traditional Chinese Medicine (TCM) has been widely applied in various cancer treatments in China. Thus far, Chinese herbal medicine (CHM) has been shown to be effective in reducing the adverse effects of chemotherapy and improving the quality of life (QoL) during chemotherapy. In the present study, a more rational and effective therapeutic scheme is to be applied to assess the effects of comprehensive rehabilitation program based on CHM and Liuzijue (LZJ) exercise combined with adjuvant chemotherapy on patients with postoperative non-small cell lung cancer (NSCLC).
Methods: A multi-center, randomized clinical trial is to be performed 354 Ib-IIIa NSCLC patients in 5 centers in China. Patients satisfying the inclusion criteria are to be randomly divided into 3 group according to the ratio of 1:1:1, namely intervention group A (IGA), intervention group B (IGB) and controlled group (CG). Each group will receive adjuvant platinum-based doublet chemotherapy for 4 cycles. IGA participants receive chemotherapy combined with CHM and LZJ exercise, IGB participants receive chemotherapy combined with CHM and rehabilitation education, and CG participants receive chemotherapy combined with placebo and rehabilitation education. The primary outcome is QoL (The European Organization for Research and Treatment of Cancer: EORTC QLQ LC43), the secondary outcomes include: (1)2 years disease-free survival rate and disease-free survival (DFS); (2) TCM symptoms; (3) tumor markers; (4) safety and adverse events (NCI CTC version 4.0).
Discussion: Our previous study reported that TCM in combination with chemotherapy could lower the overall incidence of adverse events but increase the digestive and gastrointestinal (GI) side effects than chemotherapy alone in postoperative NSCLC. The study is to lay a basis for the effectiveness of chemotherapy with or without comprehensive rehabilitation program in QoL for patients with postoperative NSCLC.
Trial Registration: ClinicalTrials.gov, NCT03372694. Registered on 17 December 2018 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03372694.
Keywords: Chinese herbal Medicine; Liuzijue exercise; Rehabilitation; Non-small cell lung cancer; Quality of Life.
Assessment of the Deformation of the Outer Nuclear Layer in the Epiretinal Membrane Using Spectral-Domain Optical Coherence Tomography
Authors: Takagi Seiji , Kudo Shigeki , Yokota Hideo , Akiba Masahiro , Mandai Michiko , Hirami Yasuhiko , Takahashi Masayo , Kurimoto Yasuo , Ishida Masahiro 
Published: February 2019

Abstract
Background: We aimed to investigate the deformation of the outer nuclear layer using optical coherence tomography in patients with epiretinal membrane (ERM) and its relationship with metamorphopsia.
Methods: Thirty-nine eyes from 39 patients with ERM were included in the study. Patients with the subtypes of pseudo macula hole and lamellar hole were excluded. Twenty-one fellow eyes without macular disease were included as normal controls. Forty-nine B-scan images were obtained in the range of 20 degrees around the macula using SD-OCT. The outer nuclear layer (ONL) was evaluated as a three-dimensional image (3D-ONL) reconstructed using the distance between the ONL and retinal pigment epithelium (RPE) line. The deformation of the ONL was figured at the reference plane and evaluation plane (ONL-B). The characteristic parameters of the ONL-B were defined as circularity, area ratio, and axis ratio. The correlations between these parameters and visual acuity and MCHART score ratio (MH/MV) were then evaluated.
Results: ONL height was significantly higher in ERM patients than in normal controls (54.1 ± 5.3 μm and 84.1 ± 12.9 μm, respectively; P<0.001). In ERM patients, the MV score was 0.53 ± 0.50, the MH score was 0.71 ± 0.61, and the distance from the RPE line to the ONL-B was 153.5 ±13.5µm. The axis of the ONL-B in normal controls and ERM patients was -6.25±21.8 and -1.28±29.1, respectively, which indicates that the ONL is horizontally long in both normal individuals and ERM patients. The circularity and area ratio were significantly smaller in ERM patients than in normal controls. In all ERM patients, MH/MV had a significant correlation with axis (r=-0.29, p=0.034), circularity (r=-0.28, p=0.044), area ratio (r=-0.47, p=0.001). Moreover, we found that the correlation was more significant if the subjects had an axis of the ONL within ± 10 degrees (n=16); the correlations of MH/MV with axis (r=-0.29, p=0.034), circularity (r=-0.53, p=0.021), and area ratio were more significant (r=-0.78, P<0.0001).
Conclusion: The ONL is horizontally long in normal individuals and ERM patients. The direction of metamorphopsia is correlated with the direction of ONL deformation.
Keywords: Epi retinal membrane, outer nuclear layer, metamorphopsia, M chart.
Age-dependent Distribution of Astigmatism and its Component in Chinese Preschool Children
Authors: Chen Minjie , Dai Jinhui , Sun Xinghuai 
Published: February 2019

Abstract
Background: There is an compensatory effect between corneal astigmatism (CA) and internal astigmatism (IA). And the refractive astigmatism (RA) decreased fast in the early 3 years. Nevertheless, little attention was paid to the change in astigmatism in preschool children. Thus, we aimed to investigate the age-dependent distribution of astigmatism and its component in Chinese preschool children from year 3 to year 6 and also, to study the relationship between ocular biometry and IA.
Methods: Automated refraction, keratometry and axial length (AL) were performed in this cross-sectional study. The IA was determined as the vector difference between RA and CA. The magnitude and type (with-the-rule WTR, against-the-rule ATR, oblique) of RA, CA and IA were investigated according to the age. Spearman correlation was adopted to detect the factors that may influence IA.
Results: A total of 2315 subjects (2315 right eyes) (47.38% female) with a mean age of 4.52±0.88 years (range 3-6 years) were included. The magnitude and the ratio of three kinds of CA components did not change with aging (p=0.1233 and p>0.1, respectively). Though the axial distribution of RA remained unchanged with aging, a significant reduction in RA was seen in year 6 compared to that of year 3 and year 4 (p=0.036 and 0.041, respectively). Conversely，the ATR component in IA was lower in year 6 (68.02%) than it in year 3 (81.92%) and year 4 (77.12%) (both p<0.001) accompanied by increased frequency of oblique astigmatism in year 6 than it in year 3 and year 4 (p<0.001 and p=0.012,respectively). Negative relationship was found between IA and AL.
Conclusion: RA decreased from year 3 to year 6. The shift of the axis in IA from ATR to Oblique and WTR may account for the reduction in RA. Eyes with shorter AL had larger IA.
Keywords: Internal astigmatism; corneal astigmatism; axial length; with-the-rule.
Minimum alveolar concentration-awake of sevoflurane in women of breast surgery with sleep disorders
Authors: Cao Yuanyuan , Zhang Lei , Peng Xiaohui , Wu Yun , Zhang Qunlin , Gu Erwei , Zhang Ye 
Published: February 2019

Abstract
Background: Sleep disorders are commonly encountered in clinic. Evidences showed that sleep deprivation may modulate the effectiveness of general anesthetics in rats. However, this phenomenon has not been explored in humans. The study aimed to investigate whether the hypnotic potency of sevoflurane in patients with sleep disorders differ from patients with normal sleep habits.
Methods: We recruited 44 patients scheduled for elective breast surgery and eventually analyzed 38 patients, including 19 subjects with normal sleep habits and 19 subjects with sleep disorders. According to the Dixon ‘up-and-down’ design, patients received sevoflurane at preselected concentrations starting at 1.0 vol%. After a steady-state period, a verbal command for testing awakening was performed. Based on the negative or positive response to the verbal command, we decreased or increased the concentration of sevoflurane by 0.2 vol% in the next patient accordingly. Plasma orexin-A was also measured before observation.
Results: The MACawake of sevoflurane was 0.80% [95% confidence interval (CI), 0.683–0.926%] in the sleep disordered group vs 0.60% [95% CI, 0.493–0.689%] in the control group. The relative median potency between groups was 0.750 (95% CI, 0.236–0.969). Patients with sleep disorders had significantly higher orexin-A levels than control (72.17 ± 18.24 vs. 36.16 ± 14.18 pg/mL). A significant, positive relationship was detected between orexin-A level and probability of awakening (OR = 1.081, 95% CI is 1.020–1.146, P = 0.008).
Conclusions: MACawake of sevoflurane is higher in patients with sleep disorders compared to those with normal sleep habits. The increased anesthetic requirement may be related to changes of orexin-A levels. These findings suggest that sleep may have a potential impact on clinical anesthesia, including changes of sensitivity to anesthetics or postoperative complications. Further research is needed to confirm this hypothesis.
Clinical Trial Registration: Chinese Clinical Trial Registry (ChiCTR1800016022), date of registration 07 May 2017.
Keywords: Sevoflurane; MACawake (minimum alveolar concentration of awake); orexin-A; sleep disorders.
O metal, suas especificidades e desdobramentos
Authors: Carvalheiro Marcus , Rauen Moraes Taiza Mara 
Published: February 2019

Este artigo objetiva apresentar os desdobramentos do metal como estilomusical advindo do rock, que a partir dos anos 1980, identifi cado como heavy metal, se tornou um gênero musical difundido mundialmente. Questiona-se o processo de atribuição de valores, assim como quais são as disputas pelo espaço urbano envolvidas nesse desenvolvimento e qual é a perspectiva do cenário atual. Os conceitos acionados para a discussão foram a teoria dos gêneros musicais, de Franco Fabbri (1980), e a concepção de subcultura, de Andy Bennet (2002), e a abordagem da relação midiática com a música foi sustentada pelas refl exões de Jeder Janotti Junior (2015).
A família rural do Piraí, políticas públicas e patrimônio cultural
Authors: Tavares Vieira Filho Adhemar , Areas Patricia De Oliveira 
Published: February 2019

A proposta deste artigo é demonstrar e analisar a relação existente entreo patrimônio cultural rural mantido e praticado pela família rural da região do Piraí, em Joinville (SC), e como as políticas públicas rurais e suas atividades podem impactar esse patrimônio cultural, tanto positiva como negativamente. Empregaram-se como metodologia a pesquisa bibliográfi ca e entrevistas semiestruturadas com técnicos e gestores da Fundação de Desenvolvimento Rural 25 de Julho do município de Joinville (responsável pelas referidas políticas à época das entrevistas) e com pessoas das famílias rurais da região do Piraí. Busca-se demonstrar que políticas públicas bem empregadas podem ser ferramentas de sustentabilidade de preservação do patrimônio cultural.
Finitude como poética
Authors: Lamas Nadja De Carvalho 
Published: February 2019

Este texto busca compreender a poética contemporânea por meio da análiseda proposição artística de Mark Formanek, apresentada na 11.ª Bienal do Mercosul, em Porto Alegre. Tal proposta rompe com a materialidade, pois a efemeridade lhe é inerente. Standard time, assim como outras produções artísticas contemporâneas, tenciona o sistema da arte, pois tem a fi nitude como parte de sua poética, proposição que evidencia o quão complexo é o mundo da arte e as problemáticas artísticas contemporâneas.
Desgaste e armazenamento das escovas dentais numa unidade oncológica infantil Dental brush wear and storage in a child oncological unit
Authors: Marin Constanza , Michels Bruna 
Published: February 2019

Introdução: A escova dental constitui o meio mais eficaz e popularizado de controle da placa bacteriana, porém pode se tornar um veículo de disseminação de microrganismos, especialmente em pacientes imunocomprometidos. Objetivo: Avaliar o desgaste e a forma de armazenamento das escovas dentais de pacientes internados no setor de oncologia de um hospital infantil do norte catarinense. Material e métodos: A pesquisa foi realizada com 30 pacientes entre 0 e 17 anos. Aplicou-se um questionário para os pais ou responsáveis legais a fim de identificar a situação socioeconômica, limpeza da escova e forma de armazenamento. As escovas foram analisadas e classificadas de acordo com o grau de desgaste das cerdas, grau de limpeza e umidade. Resultados: Grande parte dos pacientes também relatou ter complicações bucais durante a internação e tratamento oncológico (63%). Dos pacientes visitados, 27% não possuíam escova dental no momento da entrevista. Quanto às escovas analisadas, 73% estavam com grau de desgaste das cerdas em condições adequadas para uso, enquanto 27% estavam em condições inadequadas. De acordo com o grau de limpeza das escovas, 36% apresentavam restos de alimento, dentifrício ou fungo. As escovas eram armazenadas de diversas formas dentro do hospital, e a maioria foi encontrada na gaveta sem nenhuma proteção (27%). Conclusão: Há necessidade de promover maior orientação aos pacientes oncológicos quanto à troca, higienização e ao armazenamento das escovas dentais.
Tratamento de trauma oclusal anterior com pino de fibra de vidro associado à coroa de dissilicato de lítio Anterior occlusal trauma treatment with fiberglass pin associated to lithium disilicate crown
Authors: Hintz Raisa Carolina , Saab Rafaela Caramori , Garcia Eugenio , Hilgenberg Sergio Paulo , Cunha Leonardo Fernandes da , Deliberador Tatiana Miranda , Gonzaga Carla Castiglia 
Published: February 2019

Introdução: A aparência estética é uma das preocupações do ser humano, o que leva a uma busca constante por uma estética que expresse harmonia, naturalidade e expressividade. Sendo assim, os procedimentos restauradores têm contribuído positivamente para a resolução dos desafios odontológicos estéticos. Objetivo e relato de caso: Relatar um caso clínico com associação de clareamento dental, confecção de pino intrarradicular e coroa indireta em dissilicato de lítio em que foi devolvida ao paciente a estética desejada. Pacientede 23 anos de idade fraturou o incisivo central superior direito na infância; insatisfeito com a instabilidade de cor do dente, buscou novas alternativas de tratamento. Conclusão: A associação de diferentes tratamentos na Odontologia estética pode apresentar resultados satisfatórios para o restabelecimento estético e funcional de dentes anteriores.Introduction: The aesthetic appearance is one of the human being concerns, leading to constant search for an aesthetic that expresses harmony, naturalness and expressiveness. So, the restorative procedures have contributed positively to overcome the aesthetic dentistry challenges. Objective and case report: Report a clinical case in association to dental whitening, making of intraradicular pin and indirect crown of lithium disilicate when it was returned to the patient the desired aesthetic. A 23 years old patient fractured the right central incisor in the childhood, dissatisfied with the tooth color instability, he looked for new treatment alternatives. Conclusion: The association of different treatments in the aesthetic dentistry might present satisfactory results to the aesthetic and functional reestablishment of anterior teeth.
Progress of Individualized Chemotherapy for Gastric Carcinoma Under the Guidance of Genetic Testing
Authors: Jin Xin , Jiang Meng-lin , Wu Zhao-Hui , Fan Yu 
Published: February 2019

Background:Gastric cancer is a major malignancy that has high incidence rates worldwide. Approximately 30% of patients with gastric cancer have progressed into advanced stages at the time of diagnosis. Chemotherapy is the standard-of-care for most advanced gastric cancer and elicits variable responses among patients. Personalized chemotherapy based on genetic information of individual patients with gastric cancer has gained increasing attention among oncologists for guiding chemotherapeutic regimens.Methods:This review summarizes recent progress of individualized chemotherapy in gastric cancer guided by pharmacogenomics. Variable medical research search engines, such as PubMed, Google Scholar, SpringerLink and ScienceDirect, were used to retrieve related literature. Only peerreviewed journal articles were selected for further analyses.Results and Conclusion:The efficiency of chemotherapy in patients with gastric cancer is not only determined by chemotherapeutic drugs but is also directly and indirectly influenced by functionally correlative genes. Individual gene alteration or polymorphism remarkably affects patients’ responses to particular chemotherapy. Most studies have focused on the influence of single-gene alteration on a selected drug, and only a few works explored the interaction between therapeutics and a panel of genes. Individualized chemotherapy regimens guided by a genetic survey of a multiple-gene panel are expected to remarkably improve the treatment efficacy in patients with advanced gastric cancer and may become the new standard for personalizing chemotherapy for gastric cancer in the near future.