bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aqueous Stable Gold Nanostar/ZIF‐8 Nanocomposites for Light‐Triggered Release of Active Cargo Inside Living Cells
Authors: Carrillo‐Carrión Carolina , Martínez Raquel , Navarro Poupard María F. , Pelaz Beatriz , Polo Ester , Arenas‐Vivo Ana , Olgiati Alessandro , Taboada Pablo , Soliman Mahmoud G. , Catalán Úrsula , Fernández‐Castillejo Sara , Solà Rosa , Parak Wolfgang J. , Horcajada Patricia , Alvarez‐Puebla Ramon A. , del Pino Pablo 
Published: March 2019

AbstractA plasmonic core–shell gold nanostar/zeolitic‐imidazolate‐framework‐8 (ZIF‐8) nanocomposite was developed for the thermoplasmonic‐driven release of encapsulated active molecules inside living cells. The nanocomposites were loaded, as a proof of concept, with bisbenzimide molecules as functional cargo and wrapped with an amphiphilic polymer that prevents ZIF‐8 degradation and bisbenzimide leaking in aqueous media or inside living cells. The demonstrated molecule‐release mechanism relies on the use of near‐IR light coupled to the plasmonic absorption of the core gold nanostars, which creates local temperature gradients and thus, bisbenzimide thermodiffusion. Confocal microscopy and surface‐enhanced Raman spectroscopy (SERS) were used to demonstrate bisbenzimide loading/leaking and near‐IR‐triggered cargo release inside cells, thereby leading to DNA staining.
Metallfreie Tandem‐Umlagerung/Lactonisierung: Zugang zu 3,3‐disubstituierten Benzofuran‐2‐(3H)‐onen
Authors: Santi Micol , Ould Darren M. C. , Wenz Jan , Soltani Yashar , Melen Rebecca L. , Wirth Thomas 
Published: March 2019

AbstractHier wird eine neuartige metallfreie Synthese von 3,3‐disubstituierten Benzofuran‐2(3H)‐onen durch Reaktion von α‐Aryl‐α‐diazoacetaten und Triarylboranen vorgestellt. Zunächst wurden Triarylborane bei α‐Arylierungen von α‐Diazoacetaten untersucht, in Gegenwart eines Heteroatomsubstituenten in ortho‐Position erfährt das intermediäre Borenolat jedoch eine intramolekulare Umlagerung und bildet ein quartäres Zentrum. Die Zwischenprodukte cyclisieren unter Bildung von wertvollen 3,3‐disubstituierten Benzofuranonen in guten Ausbeuten.
Ultrahigh‐Loading Zinc Single‐Atom Catalyst for Highly Efficient Oxygen Reduction in Both Acidic and Alkaline Media
Authors: Li Jia , Chen Siguo , Yang Na , Deng Mingming , Ibraheem Shumaila , Deng Jianghai , Li Jing , Li Li , Wei Zidong 
Published: March 2019

AbstractAtomically dispersed Zn–N–C nanomaterials are promising platinum‐free catalysts for the oxygen reduction reaction (ORR). However, the fabrication of Zn–N–C catalysts with a high Zn loading remains a formidable challenge owing to the high volatility of the Zn precursor during high‐temperature annealing. Herein, we report that an atomically dispersed Zn–N–C catalyst with an ultrahigh Zn loading of 9.33 wt % could be successfully prepared by simply adopting a very low annealing rate of 1° min−1. The Zn–N–C catalyst exhibited comparable ORR activity to that of Fe–N–C catalysts, and significantly better ORR stability than Fe–N–C catalysts in both acidic and alkaline media. Further experiments and DFT calculations demonstrated that the Zn–N–C catalyst was less susceptible to protonation than the corresponding Fe–N–C catalyst in an acidic medium. DFT calculations revealed that the Zn–N4 structure is more electrochemically stable than the Fe–N4 structure during the ORR process.
The potential role of auditory prediction error in decompensated tinnitus: An auditory mismatch negativity study
Authors: Mohebbi Mehrnaz , Daneshi Ahmad , Asadpour Abdoreza , Mohsen Samer , Farhadi Mohammad , Mahmoudian Saeid 
Published: March 2019

AbstractIntroductionSome tinnitus subjects habituate to their tinnitus but some others do not and complain of its annoyance tremendously. Normal sensory memory and change detection processes are needed for detecting the tinnitus signal as a prediction error and habituation to tinnitus. The purpose of this study was to compare auditory mismatch negativity as the index of sensory memory and change detection among the studied groups to search for the factors involving in the perception of tinnitus and preventing habituation in decompensated tinnitus subjects.MethodsElectroencephalography was recorded from scalp electrodes in compensated tinnitus, decompensated tinnitus, and no tinnitus control subjects. Mismatch negativity was obtained using the oddball paradigm with frequency, duration, and silent gap deviants. Amplitude, latency, and area under the curve of mismatch negativities were compared among the three studied groups.ResultsThe results showed lower mismatch negativity amplitude and area under the curve for the higher frequency deviant and for the silent gap deviant in decompensated tinnitus group compared to normal control and compensated tinnitus group.ConclusionsThis study revealed a deficit in sensory memory and change detection processing in decompensated tinnitus subjects. This causes persistent prediction errors; tinnitus signal is consistently detected as a new signal and activates the brain salience network and consequently prevents habituation to tinnitus. Mismatch negativity is proposed as an index for monitoring tinnitus rehabilitation.
Effect of sulfur dioxide and lactic acid in steeping water on the extraction of anthocyanins and bioactives from purple corn pericarp
Authors: Li Qian , Singh Vijay , de Mejia Elvira Gonzalez , Somavat Pavel 
Published: March 2019

AbstractBackground and objectivesPurple corn can be an economical source of anthocyanins, a natural alternate to synthetic FD&C Red 40 dye in foods. The effects of steeping purple corn pericarp in wet milling chemicals, namely sodium metabisulfite and lactic acid, and milling on the extraction of anthocyanins, polyphenols, flavonoids, and tannins were studied.FindingsSteeping water with 2,000 ppm SO2 contained total monomeric anthocyanins (TA) equivalent of 20.5 ± 1.5 mg cyanidin‐3‐O‐glucoside (C3G)/g pericarp, higher than using only water (7.1 ± 0.6 mg C3G/g pericarp). In the treatment with SO2 and 5,000 ppm lactic acid, TA concentration was 22.9 ± 0.2 mg C3G/g pericarp. This was due to increased extraction of C3G and condensed forms of anthocyanins. Polyphenols and tannins were higher in SO2 treatments while flavonoid concentration was not different. Chroma was positively correlated with anthocyanins (r = 0.999) and tannins (r = 0.994). Ball milled pericarp fractions yielded the highest amount of anthocyanins.ConclusionsAnthocyanin recovery from purple corn pericarp can be significantly increased using a milling step prior to SO2‐based extraction.Significance and noveltyA novel method for increasing anthocyanin yields from purple corn is proposed.
Effect of Helical Surface Disc Turbulators on Heat Transfer and Friction Factor Characteristics in the Annuli of a Double‐Pipe Heat Exchanger
Authors: Yadav Saurabh , Sahu Santosh K. 
Published: March 2019

AbstractThe heat transfer and pressure drop characteristics in annuli of a double‐pipe heat exchanger (DPHE) using helical surface disc turbulators (HSDTs) are experimentally investigated. The effect of a helical surface disc turbulator is studied for three pitch ratios, three diameter ratios, and varying Reynolds numbers. Water flows in the inner tube and air through the annulus. The tests are conducted for air with uniform wall temperature condition. The heat exchanger with the least pitch ratio and least diameter ratio was found to exhibit the highest Nusselt number and pressure drop. The thermal performance factor turned out to be greater than unity for all cases. Correlations were developed for Nusselt number, friction factor, and thermal performance.
Estimation of Kinetics for Batch Cooling Crystallization by Focused‐Beam Reflectance Measurements
Authors: Unno Joi , Kawase Hiroki , Kaneshige Reiya , Hirasawa Izumi 
Published: March 2019

AbstractNumerical simulation of the seeded batch cooling crystallization process of active pharmaceutical ingredients was performed. Crystal size distribution was observed by focused‐beam reflectance measurements and concentration by simultaneous Fourier transform infrared spectroscopy. First, kinetic parameters were estimated. Nucleation rate coefficient and order were estimated from the linear regression equation between cooling rate and metastable zone width. The remaining parameters were estimated from the evaluation function. Then, the numerical simulation was performed by utilizing the method of moments. Finally, observed data were compared with simulated data. The simulated values of mean mass size corresponded reasonably with the observed ones.
Synthesis and Characterization of Sodium Dithionate and its Dihydrate
Authors: Schindler Manon , Couvrat Nicolas , Cartigny Yohann , Brandel Clément , Coquerel Gérard 
Published: March 2019

AbstractSodium dithionate (Na2S2O6) was synthesized and characterized by complementary solid‐state analyses. The obtained results enabled to describe the dehydration and decomposition phenomena under heating and reversible hydration and dehydration phenomena at relative humidity. The important role of water in the dihydrate crystalline structure is highlighted by dynamic vapor sorption (DVS) analysis, differential scanning calorimetry (DSC) analysis, and structural description.
A Mixed‐Anion System Consisting of a Germyl Anion and Anions Delocalized on Conjugated Carbon Ring Skeletons
Authors: Fujimori Shiori , Mizuhata Yoshiyuki , Tokitoh Norihiro 
Published: March 2019

AbstractInvited for the cover of this issue is the group of Norihiro Tokitoh at Kyoto University. The image depicts a mixed‐trianion system based on a 9‐germaanthracene skeleton. Read the full text of the article at 10.1002/chem.201900699.
Cobaltaelectro‐Catalyzed C−H Activation with Carbon Monoxide or Isocyanides
Authors: Sau Samaresh Chandra , Mei Ruhuai , Struwe Julia , Ackermann Lutz 
Published: March 2019

AbstractElectrochemical oxidative C−H/N−H activations with isocyanides have been realized with a versatile cobalt catalyst. The widely applicable cobalt catalysis manifold further enabled electrooxidative C−H/N−H carbonylations with carbon monoxide under ambient conditions. The C−H functionalizations were efficiently realized with ample scope and outstanding functional group tolerance in a user‐friendly undivided cell setup.
Effect of the rearing system on the color of four muscles of suckling kids
Authors: Ripoll Guillermo , Alcalde María Jesús , Argüello Anastasio , Córdoba María de Guía , Panea Begoña 
Published: March 2019

AbstractMost suckling kids are raised on farms for cheese production, and many goat farmers rear kids with milk replacers. The aim of this work was to study the influence of the use of milk replacers on the color of four muscles. A total of 246 suckling kids of eight breeds were slaughtered to achieve carcasses of 5 kg. The color of the biceps femoris, semimembranosus, semitendinosus, and longissimus thoracis muscles was measured with a spectrophotometer, and CIELab coordinates were registered. In addition, the pH of longissimus thoracis was measured. The effect of the rearing system (RS) on the color of the studied muscles is strongly modulated by breed. In general terms, there are two groups of kids according to the color of meat. The first group has great lightness and hue angle including Malagueña, Palmera, and Tinerfeña fed natural and artificial milk. The second group with great redness includes Retinta, Payoya, and Verata fed natural and artificial milk together with Florida fed natural milk and Cabra del Guadarrama fed milk replacers. Hence, farms should consider selecting a breed and RS together. Most of the kid meat with high pH comes from kids raised on milk replacers. Because artificial RSs use very early weaning, which might induce a high pH and dark meat, two artificial rearing strategies can be proposed. The first strategy is to choose less sensitive breeds that produce meat with a normal pH. The second strategy is to restrict suckling of natural milk but minimize separation from the mother.
Surgical consensus guidelines on sentinel node biopsy (SNB) in patients with oral cancer
Authors: Schilling Clare , Stoeckli Sando J. , Vigili Maurizio G. , de Bree Remco , Lai Stephen Y. , Alvarez Julio , Christensen Anders , Cognetti David M. , D'Cruz Anil K. , Frerich Bernhard , Garrel Renaud , Kohno Naoyuki , Klop Willem Martin , Kerawala Cyrus , Lawson Georges , McMahon Jeremy , Sassoon Isabel , Shaw Richard J. , Tvedskov Jesper F. , von Buchwald Christian , McGurk Mark 
Published: March 2019

AbstractBackgroundThe eighth international symposium for sentinel node biopsy (SNB) in head and neck cancer was held in 2018. This consensus conference aimed to deliver current multidisciplinary guidelines. This document focuses on the surgical aspects of SNB for oral cancer.MethodInvited expert faculty selected topics requiring guidelines. Topics were reviewed and evidence evaluated where available. Data were presented at the consensus meeting, with live debate from panels comprising expert, nonexpert, and patient representatives followed by voting to assess the level of support for proposed recommendations. Evidence review, debate, and voting results were all considered in constructing these guidelines.Results/ConclusionA range of topics were considered, from patient selection to surgical technique and follow‐up schedule. Consensus was not achieved in all areas, highlighting potential issues that would benefit from prospective studies. Nevertheless these guidelines represent an up‐to‐date pragmatic recommendation based on current evidence and expert opinion.
Tracheostomy scar management by repositioning platysma muscle and applying an acellular dermal substitute
Authors: Ha Jeong Hyun , Kim Sang Wha 
Published: March 2019

AbstractBackgroundA depressed tracheostomy scar can be esthetically unacceptable. We describe a new technique for managing tracheostomy scars using platysma muscle repositioning and the application of an acellular dermal substitute.MethodsSeventeen patients with depressed tracheostomy scars were identified for scar management. The time between tracheostomy tube removal and scar management was 29 months. Before and after the surgery, the scar was rated using the Vancouver Scar Scale (VSS).ResultsAfter surgery, tracheal tug was eliminated in all patients and the appearance of the scar was much improved. The mean total VSS score improved from 8.265 to 2.324 (P < 0.0001). The follow‐up period was 33.3 months.ConclusionsThe management of tracheostomy scars by repositioning platysma muscle and applying an acellular dermal substitute is simple and efficient. The technique recovers the lost deep tissue volume, corrects tracheal skin tug, and enables tension‐free skin closure to restore the normal contour of the neck.
Hydroperoxyditerpenoids from Octocorals
Authors: Sheu Jyh‐Horng , Peng Bo‐Rong , Fang Lee‐Shing , Hwang Tsong‐Long , Su Jui‐Hsin , Wu Yang‐Chang , Sung Ping‐Jyun 
Published: March 2019

AbstractThe structures, names, bioactivities, and references of 75 marine diterpenoids from octocorals possessing a hydroperoxy group, including 46 cembranes, 8 eunicellins, 5 briaranes, 5 dolabellanes, 4 germacranes, 3 xenicins, 2 caryophyllanes, 1 decalin, and 1 pseudopterosin, are summarized in this review article. All the hydroperoxyditerpenoids mentioned in this review were isolated from octocorals from Alcyonacea (Briareum excavatum, Briareum polyanthes, Briareum violaceum, Briareum sp., Cespitularia sp., Cladiella tuberculosa, Cladiella sp., Clavularia inflata, Klyxum simplex, Lemnalia sp., Lobophytum crassum, Lobophytum sp., Nephthea pacifica, Sarcophyton cherbonnieri, Sarcophyton crassocaule, Sarcophyton glaucum, Sarcophyton mililatensis, Sarcophyton trocheliophorum, Sarcophyton sp., Sinularia arborea, Sinularia erecta, Sinilaria flexibilis, Sinularia gibberosa, Sinularia manaarensis, Xenia umbellata) and Gorgonacea (Astrogorgia sp., Eunicea calyculata, Eunicea pinta, Eunicea succinea, Eunicea sp., Pseudopterogorgia sp.). Among these isolates, 41 compounds exhibited potential biomedical activities, including cytotoxicity, antimalarial activity, anti‐inflammatory activity, and antibacterial activity.
Improvisational Teaching as Being With: Cultivating a Relational Presence Toward Justice‐Oriented Literacies
Authors: Zapata Angie , Van Horn Selena , Moss Daryl , Fugit Misha 
Published: March 2019

AbstractThe authors (two classroom teacher researchers and two university researchers) explore the potential of improvisational teaching for justice‐oriented literacy instruction with adolescent youths. In the aftermath of racial unrest and student activism at the University of Missouri and when faced with the emerging confusions among students in response to global humanitarian crises, the two teachers encountered tensions and emerging justice‐oriented literacies through a relational presence in the classroom. Guided by the scholarship on improvisational planning and teaching, the authors explore how teachers’ being with the major resources in the room produce generative literacy sites of critical discussion, reading, writing, and making as acts of creative resistance and solidarity. Throughout the article, the authors juxtapose the two teaches’ feelings and voices to amplify their differences and their affectual responses to encountered tensions to evoke new conditions of possibilities for justice‐oriented literacy education.
Role of HGF/c‐Met in the treatment of colorectal cancer with liver metastasis
Authors: Yao Jian‐feng , Li Xiao‐jun , Yan Li‐kun , He Sai , Zheng Jian‐bao , Wang Xiao‐rong , Zhou Pei‐hua , Zhang Li , Wei Guang‐bing , Sun Xue‐jun 
Published: March 2019

AbstractThe system of hepatocyte growth factor (HGF) and its receptor c‐Met plays a critical role in tumor invasive growth and metastasis. The mortality rate of colorectal cancer (CRC), one of the most commonly diagnosed malignancies, is increased by it gradual development into metastasis, most frequently in the liver. Overexpression of c‐Met, the protein tyrosine kinase receptor for the HCF/scatter factor, has been implicated in the progression and metastasis of human colorectal carcinoma. In this study, we aimed to investigate the role of c‐Met in CRC liver metastasis and illustrate the clinical impact of regulating HGF/c‐Met signaling in patients with CRC liver metastasis. We found that (I) higher levels of c‐Met expression (mRNA and Protein) in CRC liver metastasis than primary CRC by assessing the patient tissue samples; (II) a positive correlation of c‐Met expression with tumor stages of CRC liver metastasis, as well as c‐Met expression in CRC, live metastasis concurred with regional lymph node metastasis; (III) the clinical impact of downregulation of HGF/c‐Met signaling on the reduction of proliferation and invasion in CRC liver metastasis. Therefore, we demonstrate that the regulation of HGF/c‐Met pathways may be a promising strategy in the treatment of patients with CRC liver metastasis.
Protective effect of daidzein against streptozotocin‐induced Alzheimer's disease via improving cognitive dysfunction and oxidative stress in rat model
Authors: Wei Jie , Yang Fenggang , Gong Chuanbao , Shi Xingyuan , Wang Guangliang 
Published: March 2019

AbstractOxidative stress is performing an essential role in developing Alzheimer's disease (AD), and age‐related disorder and other neurodegenerative diseases. In existing research, we have aimed at investigating the daidzein (4′,7‐dihydroxyisoflavone) effect (10 and 20 mg/kg of body weight), as a free radical scavenger and antioxidant in streptozotocin (STZ) infused AD in rat model. Daidzein treatment led to significant improvement in intracerebroventricular‐streptozotocin (ICV‐STZ)‐induced memory and learning impairments that was evaluated by Morris water maze test and spontaneous locomotor activity. It significantly restored the alterations in malondialdehyde, catalase, superoxide dismutase, and reduced glutathione levels. In addition, histopathological observations in cerebral cortex and hippocampal areas confirmed the neuroprotective effect of daidzein. These outcomes provide experimental proof showing preventive effect of daidzein on memory, learning dysfunction and oxidative stress in case of ICV‐STZ rats. In conclusion, daidzein offers a potential treatment module for various neurodegenerative disorders with regard to mental deficits like AD.
Prognostic and diagnostic significance of circRNAs expression in lung cancer
Authors: Huang Xin , Zhang Weiyue , Shao Zengwu 
Published: March 2019

AbstractCircular RNAs (circRNAs) have spurred considerable interest in numerous tumors. We aimed to investigate the clinical, prognostic, and diagnostic roles of circRNAs in human lung cancer. We systematically searched PubMed, Web of Science, EMBASE, Scopus, CBM, and the Cochrane Library databases up to July 24, 2018. Eligible studies about the relationship between circRNAs expression and clinical, prognostic, and diagnostic outcomes in patients with lung cancer were in our study. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were to investigate clinical parameters, and hazard ratios (HRs) and 95% CIs to estimate overall survival (OS). A total of 23 relevant studies were eligible, with 15 on clinicopathological features, 14 on prognosis, and six on diagnosis. For clinical features, high expression of oncogenic circRNAs was remarkably related to poor clinical parameters. Whereas, the results of tumor‐suppressor circRNAs were the complete opposite. For the prognostic roles, oncogenic circRNAs had an unfavorable impact on overall survival (OS: HR = 3.24, 95% Cl: 2.70–3.77), and elevated level of tumor‐suppressor circRNAs was correlated with longer survival (OS: HR = 0.57, 95% Cl: 0.43–0.70). For the diagnostic values, the pooled result showed an area under the curve (AUC) of 0.86, with 77% sensitivity and 81% specificity in distinguishing patients with lung cancer from healthy ones. The above results suggested that circRNAs have the potential to be novel indicators for prognostic and diagnostic evaluation of patients with lung cancer.
Increased IGF2BP3 expression promotes the aggressive phenotypes of colorectal cancer cells in vitro and vivo
Authors: Xu Weimin , Sheng Yaru , Guo Yuegui , Huang Zhenyu , Huang Yiji , Wen Dongpeng , Liu Chen‐Ying , Cui Long , Yang Yili , Du Peng 
Published: March 2019

AbstractPrevious literatures reported insulin‐like growth factor‐2 messenger RNA‐binding protein 3 (IGF2BP3) is a poor prognostic marker for colorectal cancer (CRC) patients. However, basic research on the effect and biological role of IGF2BP3 in CRC was still scare. Real‐time quantitative polymerase chain reaction and western blot analysis were used to examine IGF2BP3 expression level in tumors and paired normal tissues from CRC patients. Tissue microarrays with 192 CRC patients were subjected to immunohistochemical staining to analyze the prognostic value of IGF2BP3. Proliferation assays, migration assays, and xenograft tumor formation in nude mice were performed to assess the biological role of IGF2BP3 in CRC cells. IGF2BP3 expression was significantly upregulated in tumor tissues compared with the matched normal tissues both in messenger RNA and protein level and was associated with worse prognosis. IGF2BP3 knockdown made cell cycle arrest to impair the proliferation ability of CRC cells and further inhibited the xenograft tumor growth in nude mice, also inhibited the migration ability of CRC cells via inducing epithelial–mesenchymal transition. Therefore, the research demonstrated that increased IGF2BP3 expression promoted the aggressive phenotypes of CRC cells. Targeted IGF2BP3 could be a novel and effective gene therapy for CRC patients to make a better prognosis.