bluuebunny/crossref_metadata_2025_split huggingface dataset:
How the health institution combinative contracting mechanism influences community residents' patient experiences in Shanghai: A comparative study of data from two cross‐sectional surveys
Authors: He Jiangjiang , Chen Duo , Tang Zhenqing , Cong Lixuan , Tian Yuan , Xie Chunyan , Wang Linan , Xu Jiajie , Jin Chunlin , Chen Wen 
Published: August 2019

SummaryObjectiveTo understand the effect of the health institution combinative contracting mechanism (which make participating residents make a “combinative contracting” involving family doctor of community health center, one secondary hospital, and one tertiary hospital) on community residents' patient experiences in Shanghai, China.MethodsWe conducted two questionnaire surveys (2016 and 2018) on the patient experiences of 1200 permanent residents of 12 subdistricts of Shanghai, who were selected via stratified random sampling. Of these, 926 participants were included after propensity score matching. We compared five dimensions of patient experience—accessibility, environment and facilities, service attitude and emotional support, communication and patient engagement, and service integration—before and after implementation of the health institution combinative contracting mechanism in June 2016. Furthermore, logistic regression analysis was used to explore the factors related to residents' overall experience.ResultsThe health institution combinative contracting mechanism influenced most dimensions of residents' patient experience, such as accessibility, service attitude and emotional support, communication and patient participation, and service integration. The mechanism in general helped contracted residents obtain a better patient experience than before its implementation. Referral had a significant effect on participants' overall experience.ConclusionContracted family doctors play active roles in improving nearly every dimension of residents' service experience, as well as their overall experience of services. The health institution combinative contracting mechanism not only increases interaction and strengthens trust between doctors and patients but also makes it possible for residents to obtain integrated health services.
Influence of the induced magnetic field and heat transfer on peristaltic transport of a micropolar fluid in a tapered asymmetric channel
Authors: Kotnurkar Asha S. , Katagi Deepa C. 
Published: August 2019

AbstractIn this paper, we investigate the peristaltic transport of a micropolar fluid in a tapered asymmetric channel with heat transfer and induced magnetic field effect. The flow is analyzed by long wavelength and low Reynolds number approximations. The reduced equations have been solved by using Adomian decomposition method and the expressions for velocity, stream function, microrotation component, magnetic‐force function, pressure gradient, axial induced magnetic field, and current density distribution across the channel have been computed. Expressions for shear stresses are also obtained. The effect of pertinent parameters is illustrated graphically.
Internal capital market mergers in weak external market environment: An emerging market evidence
Authors: Huang Wei , Zhang Hong , Goyal Abhinav , Laws Jason 
Published: August 2019

AbstractUsing Chinese split‐share structure reform as backdrop, we study the alternative theories explaining the change in objectives of internal capital markets (ICMs) after regulatory intervention. Focusing on related party merger and acquisitions, as the primary form of ICM transactions in China, we document significantly positive performance improvement among the acquiring firms around related party than nonrelated party merger and acquisitions in the period following the split‐share structure reform. This evidence is particularly stronger among acquirers with lower institutional shareholding. Our findings are invariant to the length of performance evaluation window, matched samples, model specifications, acquirers' ownership structure, and business group affiliations. After controlling for alternative channels of tunnelling and propping, contrary to the popular belief, our findings support the bright‐side view of ICMs postregulatory intervention in an emerging market set‐up.
Monosodium Glutamate Supplementation Improves Bone Status in Mice Under Moderate Protein Restriction
Authors: Blais Anne , Rochefort Gael Y , Moreau Manon , Calvez Juliane , Wu Xin , Matsumoto Hideki , Blachier François 
Published: August 2019

ABSTRACTAdequate protein intake during development is critical to ensure optimal bone gain and to attain a higher peak bone mass later. Using a mild protein restriction model in Balb/C mice consuming 6% of their total energy intake as soy protein (LP‐SOY)—for which we observed a significantly lower femoral cortical thickness, bone volume, trabecular number, and thickness reduction—we evaluated the effects of monosodium glutamate (MSG) supplementation at different concentrations (0.5, 1, 5, 10, and 20 g/kg of diet) on bone characteristics in LP‐SOY‐fed mice. After 6 and 12 weeks, LP‐SOY‐fed mice had lower BMD and reduced body weight related to lower lean mass, which was associated with a reduced IGF‐1 level. The negative effect of the LP‐SOY diet on BMD correlated with impaired bone formation. MSG supplementation, at 5, 10, and 20 g/kg of diet, and PTH injection, used as a positive control, were able to improve BMD and to increase osteoblast activity markers (P1NP and osteocalcin), as well as glutamine plasma concentration. An analysis of bone microarchitecture found that cortical bone was less sensitive to protein restriction than trabecular bone, and that MSG ingestion was able to preserve bone quality through an increase of collagen synthesis, although it did not allow normal bone growth. Our study reinforces the view that glutamate can act as a functional amino acid for bone physiology and support clinical investigation of glutamate supplementation in adults characterized by poor bone status, notably as a result of insufficient protein intake. © 2019 The Authors.JBMR Pluspublished by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.
A New 1,25 Dihydroxy Vitamin D Analog with Strong Bone Anabolic Activity in OVX Rats with Little or no Bone Resorptive Activity
Authors: Plum Lori A , Zella Julia , Clagett-Dame Margaret , DeLuca Hector F 
Published: August 2019

ABSTRACT
A new 1α,25-dihydroxy vitamin D3 analog (2-methylene-22(E)-(24R)-22-dehydro-1α,24,25-trihydroxy-19-norvitamin D3 or WT-51) has been tested as a possible therapeutic for osteoporosis. It is 1/10th as active as 1,25(OH)2D3 in binding affinity for the vitamin D receptor but is at least 200 times more active than 1,25(OH)2D3 and equal to that of 2MD (2-methylene-19-nor-(20S)-1α,25(OH)2D3, an analog previously tested in postmenopausal women), in supporting bone formation by isolated osteoblasts in culture. However, in contrast to 2MD, it is virtually inactive on bone resorption in vivo. WT-51 markedly increased bone mass (lumbar and femur) in ovariectomized (OVX) female rats. Further, bone strength tested by the three-point bending system is significantly increased by WT-51. Thus, WT-51 is an attractive candidate for the treatment of postmenopausal osteoporosis. © 2019 American Society for Bone and Mineral Research.
HIF1A/miR‐20a‐5p/TGFβ1 axis modulates adipose‐derived stem cells in a paracrine manner to affect the angiogenesis of human dermal microvascular endothelial cells
Authors: Xiong Xiang , Sun Yang , Wang Xiancheng 
Published: August 2019

AbstractAngiogenic cytokines secreted by the adipose‐derived stem cells (ADSCs) might promote the angiogenesis of endothelial cells. In the present study, we hypothesize that miR‐20a targets TGFB1 to modulate the transforming growth factor β1 (TGFβ1) secretion by ADSCs, therefore affecting the angiogenesis. We found that hypoxia‐inducible factor 1A (HIF1A) and TGFβ1 expressions were increased by hypoxia, accompanied with promoted ADSC cell viability. Incubation with conditioned medium from ADSCs treated with hypoxia significantly enhanced the angiogenesis capacity of human dermal microvascular endothelial cells (HDMECs), while TGFB1‐silenced ADSCs medium significantly reverses HDMECs angiogenesis. miR‐20a suppresses the expression of TGFB1 and secretion of TGFβ1 by ADSCs via binding to its 3′untranslated region, therefore modulating the HDMEC angiogenesis via affecting the paracrine from ADSCs; the effects of miR‐20a‐overexpressed conditioned medium on HDMEC angiogenesis were significantly reversed by TGFB1‐overexpressed conditioned medium. Finally, HIF1A suppressed the expression of miR‐20a via targeting its promoter region, subsequently promoting the paracrine from ADSCs and HDMEC angiogenesis.
The effects of electrolyte on the capacitive behavior of nanostructured molybdenum oxides
Authors: Farsi Hossein , Moghiminia Shokufeh , Raissi Heidar , Riley Andrew , Li Zhihai 
Published: August 2019

AbstractBACKGROUNDNanostructured metal oxides have shown capabilities in the application of energy conversion and storage. Among a variety of metal oxide semiconducting materials, molybdenum oxide recently became a promising candidate as an electrochemical supercapacitor for storing electrical energy. Supercapacitors, which are storage devices for electrical energy, benefit from the separation of opposite charges in electrochemical double‐layer capacitors and charge transfer as a function of electrochemical potential in pseudocapacitors.RESULTSA thin film of nanostructured molybdenum oxide was prepared using potentiodynamic electrodeposition on the surface of a stainless‐steel electrode. Its electrochemical capacitive behavior was investigated using cyclic voltammetry and electrochemical impedance spectroscopy (EIS). To investigate the effects of the electrolyte ion type, two solutions were investigated in a comparative way: 0.005 mol L–1 H2SO4 and 0.005 mol L–1 H2SO4 + 0.095 mol L–1 Na2SO4 mixture where each solution has the same initial concentrations of hydronium ions but with different ionic strengths. The EIS studies gave rise to the specific capacitances of 340 and 160 F g–1 for H2SO4 and mixed solutions, respectively. An appropriated electrical circuit was used to interpret these EIS results.CONCLUSIONSThe present studies show that the electrolyte cations contribute to the capacitive behavior of the nanostructured molybdenum oxide in different ways. Sodium ions only participate in the process of charging the double layer from the outer Helmholtz and diffusion layers, whereas hydronium ions contribute to the Faradaic process of electrosorption by penetrating into the inner Helmholtz layer. © 2019 Society of Chemical Industry
Novel functions of inactive rhomboid proteins in immunity and disease
Authors: Geesala Ramasatyaveni , Issuree Priya D , Maretzky Thorsten 
Published: August 2019

AbstractiRhoms are related to a family of intramembrane serine proteinases called rhomboids but lack proteolytic activity. In mammals, there are two iRhoms, iRhom1 and iRhom2, which have similar domain structures and overlapping specificities as well as distinctive functions. These catalytically inactive rhomboids are essential regulators for the maturation and trafficking of the disintegrin metalloprotease ADAM17 from the endoplasmic reticulum to the cell surface, and are required for the cleavage and release of a variety of membrane-associated proteins, including the IL-6 receptor, l-selectin, TNF, and EGFR ligands. iRhom2-dependent regulation of ADAM17 function has been recently implicated in the development and progression of several autoimmune diseases including rheumatoid arthritis, lupus nephritis, as well as hemophilic arthropathy. In this review, we discuss our current understanding of iRhom biology, their implications in autoimmune pathologies, and their potential as therapeutic targets.
Interobserver agreement of PI‐RADS v. 2 lexicon among radiologists with different levels of experience
Authors: Mussi Thais C. , Yamauchi Fernando I. , Tridente Cássia F. , Tachibana Adriano , Tonso Victor M. , Recchimuzzi Débora Z. , Leão Layra R.S. , Luz Daniel C. , Martins Tatiana , Baroni Ronaldo H. 
Published: August 2019

BackgroundEvaluation of interobserver agreement of the PI‐RADS v2 lexicon is important to validate the uniformity of this widely used classification.PurposeTo determine the interobserver agreement of PI‐RADS v2 lexicon among eight radiologists with varying levels of experience.Study TypeRetrospective.PopulationIn all, 160 consecutively imaged men with confirmatory targeted biopsy.Field Strength/Sequence3T scanner without an endorectal coil. T2‐weighted imaging (T2w), diffusion‐weighted imaging (DWI), apparent diffusion coefficient (ADC) map and dynamic contrast‐enhanced sequence were performed.AssessmentEight radiologists (two highly experienced, two moderately experienced, and four less experienced) independently read 130 lesions in the peripheral zone (PZ) and 30 lesions in the transition zone (TZ), blinded to clinical MRI indication and biopsy results. The features described in PI‐RADS v2 for TZ and PZ lesions were evaluated.Statistical TestsConger's kappa, percentage of concordance, and first‐order agreement coefficient (AC1) were used to evaluate interobserver agreement.ResultsFrom the features evaluated on PZ lesions, definite extraprostatic extension (EPE) / invasive behavior on T2w had good agreement (AC1 = 0.80), and the others had fair agreement (AC1 = 0.32–0.40). From the features evaluated on TZ lesions, two had good agreement: definite EPE/invasive behavior (AC1 = 0.77) and moderate/marked hypointensity (AC1 = 0.67) on T2w. Encapsulation and lenticular shape on T2w, focal (not indistinct) on DWI and ADC map, and marked hypointensity on ADC map (AC1 = 0.45 to 0.60) had moderate agreement, whereas heterogeneous and circumscribed (not obscured margins) on T2w, marked hyperintensity on high‐b‐value DWI, and the presence or not of early enhancement in the lesion/region of the lesion (AC1 = 0.30 to 0.38) had fair agreement.Data ConclusionInterobserver agreement in PI‐RADS v2 lexicon ranges from fair to good among radiologists and improves with increasing experience.Level of Evidence: 2Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2020;51:593–602.
Ozone technology to reduce zearalenone contamination in whole maize flour: degradation kinetics and impact on quality
Authors: Alexandre Allana Patrícia Santos , Castanha Nanci , Costa Naiara Silva , Santos Amanda Silva , Badiale‐Furlong Eliana , Augusto Pedro Esteves Duarte , Calori‐Domingues Maria Antonia 
Published: August 2019

AbstractBACKGROUNDMaize is one of the most important cereals. It is used for different purposes and in different industries worldwide. This cereal is prone to contamination with mycotoxins, such as zearalenone (ZEN), which is produced mainly by Fusarium graminearum, F. culmorum and F. equiseti. Toxin production under highly moist conditions (aw > 0.95) is exacerbated if there are alternations between low temperatures (12–14 °C) and high temperatures (25–28 °C). Even if good production practices are adopted, mycotoxins can be found in several stages of the production chain. For this reason, an alternative to reducing this contamination is ozonation. This study evaluated the reduction of ZEN in naturally contaminated whole maize flour (WMF) treated with 51.5 mg L−1 of ozone for up to 60 min. Pasting properties, peroxide value, and fatty acid composition were also evaluated.RESULTSZearalenone degradation in ozonated WMF was described by a fractional first‐order kinetic, with a maximum reduction of 62.3% and kinetic parameter of 0.201 min−1 in the conditions that were evaluated. The ozonation process in WMF showed a decrease in the apparent viscosity, a decrease in the proportion of linoleic, oleic, and α‐linolenic fatty acids, an increase in the proportion of palmitic acid, and an increase in the peroxide value.CONCLUSIONOzonation was effective in reducing ZEN contamination in WMF. However, it also modified the pasting properties, fatty acid profile, and peroxide value, affecting functional and technological aspects of WMF. © 2019 Society of Chemical Industry
Revealing the Buildup Dynamics of Harmonic Mode‐Locking States in Ultrafast Lasers
Authors: Liu Xueming , Pang Meng 
Published: August 2019

AbstractHarmonic mode‐locking (HML) is an important technique enabling the generation of high‐repetition‐rate ultrashort pulses. Using an emerging time‐stretch dispersive Fourier transform technique, the experimental observation of the entire buildup process of the passive HML state in an ultrafast fiber laser is reported here. It is unveiled that the whole process of HML buildup successively undergoes seven different ultrafast phases: raised relaxation oscillation, spectral beating behavior, birth of a giant pulse, self‐phase‐modulation‐induced instability, pulse splitting, repulsion and separation of multiple pulses, and a stable HML state. It is observed that the multiple HML pulses originate from a single‐pulse splitting phenomenon and a remarkable breathing behavior occurs at an early stage of the HML buildup process. The numerical results confirm that the effects of dispersive wave, gain depletion and recovery, and acoustic wave play key roles in the earlier, middle, and later stages of this HML buildup process, respectively; as well, the acoustic resonance in the single‐mode fiber stabilizes the final HML state of lasers.
Circulating miR‐130 and its target PPAR‐γ may be potential biomarkers in patients of coronary artery disease with type 2 diabetes mellitus
Authors: Yuan Yonggang , Peng Wanzhong , Liu Yongxing , Xu Zesheng 
Published: August 2019

AbstractBackgroundPatients of coronary artery disease (CAD) with type 2 diabetes mellitus (DM2) show increased mortality risk than CAD patients without DM2, while few biomarkers can be used to discriminate them.MethodsFifty‐nine patients of CAD with DM2 (DM2‐CAD group), 79 patients of CAD without DM2 (CAD group), and 63 healthy control subjects were recruited. Circulating miR‐130 (miR‐130a and miR‐130b) and PPAR‐γ (peroxisome proliferator‐activated receptor gamma) were measured and their Pearson correlation was analyzed. 3′ UTR binding prediction and luciferase assay were used to determine the target relationship between miR‐130 and PPAR‐γ. Receiver operating characteristics (ROC) analysis was performed to test the discrimination ability of miR‐130 between DM2‐CAD and CAD groups.ResultsmiR‐130a and miR‐130b showed decreased expression in DM2‐CAD group when compared with the CAD group and health control. Both bioinformatics and luciferase assays showed that miR‐130 could bind the 3′ UTR of PPAR‐γ. Furthermore, miR‐130 negatively correlated with PPAR‐γ in both CAD and DM2‐CAD group in Pearson's coefficient analysis. Both miR‐130a and miR‐130b were able to discriminate DM2‐CAD group from CAD group and control subjects.ConclusionCirculating miR‐130 may regulate the expression of PPAR‐γ and can be used as a biomarker to discriminate DM2‐CAD from CAD.
Novel POLR1C mutation in RNA polymerase III‐related leukodystrophy with severe myoclonus and dystonia
Authors: Kraoua Ichraf , Karkar Adnane , Drissi Cyrine , Benrhouma Hanene , Klaa Hedia , Samaan Simon , Renaldo Florence , Elmaleh Monique , Ben Hamouda Mohamed , Abdelhak Sonia , Boespflug‐Tanguy Odile , Ben Youssef‐Turki Ilfghem , Dorboz Imen 
Published: August 2019

AbstractIntroductionRNA polymerase III (Pol III)‐related leukodystrophies are a group of autosomal recessive neurodegenerative disorders caused by mutations in POLR3A and POLR3B. Recently a recessive mutation in POLR1C causative of Pol III‐related leukodystrophies was identified.MethodsWe report the case of a Tunisian girl of 14 years of age who was referred to our department for evaluation of progressive ataxia that began at the age of 5. Genetic diagnosis was performed by NGS and Sanger analysis. In silico predictions were performed using SIFT, PolyPhen‐2, and Mutation Taster.ResultsNeurological examination showed cerebellar and tetrapyramidal syndrome, mixed movement disorders with generalized dystonia and severe myoclonus leading to death at 25 years. Brain MRI scans showed diffuse hypomyelination associated with cerebellar atrophy. It also showed bilateral T2 hypointensity of the ventrolateral thalamus, part of the posterior limb of the internal capsule, the substantia nigra and the subthalamic nucleus. Next generation sequencing leukodystrophy panel including POLR3A and POLR3B was negative. Sanger sequencing of the coding regions of POLR1C revealed a novel homozygous mutation.ConclusionThe clinical and imaging findings of patients with POLR1C hypomyelinating leukodystrophy are reviewed. Interestingly, severe myoclonic dystonia and T2 hypointensity of the substantia nigra and the subthalamic nucleus are not reported yet and could be helpful for the diagnosis of POLR1C hypomyelinating leukodystrophy.
An analytical model for chemical diffusion in layered contaminated sediment systems with bioreactive caps
Authors: Yan Huaxiang , Wu Jiawei , Xie Haijian , Thomas Hywel R. , Feng Shijin 
Published: August 2019

SummaryAn analytical model for contaminant transport in multilayered capped contaminated sediments including the degradation of organic contaminant is presented. The effect of benthic boundary layer was treated as a Robin‐type boundary condition. The results of the proposed analytical model agree well with experimental data. The biodegradation of contaminant in bioturbation layer shows a significant influence on the flux at the surface of system. The maximum flux for the case witht1/2,bio = 0.07 year can be 4.5 times less than that of the case without considering the effect of biodegradation. The thickness of bioturbation layer has a significant effect on the performance of the capped contaminated sediment. The maximum flux for the case withlbio = 15 cm can be 17 times larger than that of the case without bioturbation layer. This may be because the effective diffusion coefficient of sand cap can be 28 times lower thanDbio. The mass transfer coefficient should be considered for the design of the capping system as the contaminant concentration at the top of system for the case withkbl = 2.5 × 10−5 cm/s can be 13 times greater than that of the case withkbl = 10−4 cm/s. The proposed analytical model can be used for verification of complicated numerical methods, evaluation of experimental data, and design of the capping contaminated sediment systems with reactive cap layers.
A co‐rotational weak‐form quadrature planar beam element for geometric nonlinear static and dynamic analysis
Authors: Yuan Zhangxian , Wang Xinwei , Kardomateas George A. 
Published: August 2019

SummaryThe co‐rotational formulation of quadrature planar beam element undergoing large displacement and large rotation is presented. A local frame co‐rotates with the differential element and decomposes the motion into a rigid body movement and a strain‐producing deformation. General explicit formulations of elemental vectors and matrices, including internal force vector, external force vector, tangent stiffness matrix, and mass matrix, are derived via the numerical integration together with the differential quadrature law. Thus, the element nodes and numerical integration method can be chosen arbitrarily based on the accuracy requirement and problem type. A number of case studies on the static, postbuckling, and dynamic response of beams and frame structures are conducted. The convergence study shows that the co‐rotational quadrature element has an exponential rate of convergence and the reduced Gauss integration yield the highest accuracy. It is seen that the proposed co‐rotational quadrature beam element is simple in formulations, computationally efficient, and capable of capturing the complex nonlinear behavior of beam and frame structures with high precision.