bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular propellants for ion thrusters
Authors: Dietz Patrick , Gärtner Waldemar , Koch Quirin , Köhler Peter E , Teng Yan , Schreiner Peter R , Holste Kristof , Klar Peter J 
Published: June 2019

Abstract
There is no ideal atomic propellant for ion thrusters. Xenon commonly used as propellant becomes resource-critical in light of electric propulsion commercialization. Combining these considerations leads to seeking alternatives to xenon as propellant. In this review, we summarize the current literature on molecular propellants. We define two classes of molecules, group I and II, comprising diatomic molecules and more complex molecules, respectively. We identify basic properties which a candidate molecule belonging to either group, I or II, should possess in order to be suitable as molecular propellant. We discuss the pits and traps in testing such candidate molecules inside a thruster on the basis of our experiences with iodine (a member of group I) and adamantane (a member of group II). The thruster system needs to be individually adopted for each propellant candidate in order to enable a thorough testing inside the thruster. The same holds for optimizing the thruster’s performance when fed with a new propellant because the microscopic processes occurring inside the plasma will differ from molecule to molecule. These circumstances make such testing time-consuming and costly. To accelerate systematic screening of the vast number of molecular species in terms of suitability as propellant, we propose a screening and evolution procedure based on combining chemical engineering and fundamental physical measurements.
On modules 𝑀 with 𝜏(𝑀)≅𝜈Ω^{𝑑+2}(𝑀) for isolated singularities of Krull dimension 𝑑
Authors: Marczinzik René 
Published: June 2019

A classical formula for the Auslander–Reiten translate

τ
\tau

says that

τ
(
M
)
≅
ν

Ω
2

(
M
)

\tau (M)\cong \nu \Omega ^2(M)

for every indecomposable module

M
M

of a selfinjective Artin algebra. We generalise this by showing that for a

2
d

2d

-periodic isolated singularity

A
A

of Krull dimension

d
d

, we have for the Auslander–Reiten translate of an indecomposable nonprojective Cohen-Macaulay

A
A

-module

M
M

,

τ
(
M
)
≅
ν

Ω

d
+
2

(
M
)

\tau (M)\cong \nu \Omega ^{d+2}(M)

if and only if

Ext
A

d
+
1

⁡
(
M
,
A
)
=

Ext
A

d
+
2

⁡
(
M
,
A
)
=
0

\operatorname {Ext}_A^{d+1}(M,A)=\operatorname {Ext}_A^{d+2}(M,A)=0

. We give several applications for Artin algebras.
Delirium research, education and practice
Authors: MacLullich Alasdair M J , Shenkin Susan D 
Published: June 2019

Abstract
Delirium research and clinical care have seen great strides in the last decade. Age and Ageing is making freely available an online collection of 15 papers published since 2012 which provides an overview of the range of research in delirium. It covers prevention and prediction, interventions and their health economic evaluations, outcomes following delirium, and clinical application in a review of the recent SIGN guidelines. The majority of studies took place in hospitals, but we also introduce some important research about another group at high risk of delirium: care home residents. We highlight the importance of delirium education. The studies comprised a range of methodologies (systematic reviews/meta-analysis, observational studies, trials and qualitative research). The selected papers are exemplars of work that has clear clinical implications. Given that delirium affects 15–20% of hospital patients, studies or analysis of existing data with clinical relevance have the potential for enormous impact on practice and on more efficient use of healthcare resources. There is, however, still a great deal of work to be done to implement what is known to be effective, and so reduce the incidence of this distressing condition, and to support those affected: not only patients, but also families and carers, as well as staff in secondary and primary care, including care homes.
Gamma models for estimating the odds ratio for a skewed biomarker measured in pools and subject to errors
Authors: Van Domelen Dane R , Mitchell Emily M , Perkins Neil J , Schisterman Enrique F , Manatunga Amita K , Huang Yijian , Lyles Robert H 
Published: June 2019

SUMMARY
Measuring a biomarker in pooled samples from multiple cases or controls can lead to cost-effective estimation of a covariate-adjusted odds ratio, particularly for expensive assays. But pooled measurements may be affected by assay-related measurement error (ME) and/or pooling-related processing error (PE), which can induce bias if ignored. Building on recently developed methods for a normal biomarker subject to additive errors, we present two related estimators for a right-skewed biomarker subject to multiplicative errors: one based on logistic regression and the other based on a Gamma discriminant function model. Applied to a reproductive health dataset with a right-skewed cytokine measured in pools of size 1 and 2, both methods suggest no association with spontaneous abortion. The fitted models indicate little ME but fairly severe PE, the latter of which is much too large to ignore. Simulations mimicking these data with a non-unity odds ratio confirm validity of the estimators and illustrate how PE can detract from pooling-related gains in statistical efficiency. These methods address a key issue associated with the homogeneous pools study design and should facilitate valid odds ratio estimation at a lower cost in a wide range of scenarios.
Making Crime a Sustainable Development Issue: From ‘Drugs and Thugs’ to ‘Peaceful and Inclusive Societies’
Authors: Blaustein Jarrett , Chodor Tom , Pino Nathan W 
Published: June 2019

AbstractDevelopment has long featured on the United Nations (UN) crime policy agenda; however, crime was only officially recognized by the international community as a global development priority following the adoption of the Sustainable Development Goals in 2015. Adopting a sociological institutionalist perspective, this article sets out to account for how this recognition was achieved. We draw on interviews with senior UN crime policy insiders and documentary sources to analyse the efforts of the United Nations Office on Drugs and Crime (UNODC) to amplify awareness of the crime-development link following the omission of this issue from the Millenium Development Goals and amidst significant institutional and material pressures to strengthen its ties to the wider UN system. The article accounts for the political construction of the crime-development nexus and the important role that UNODC has historically played in facilitating global governance in this emergent and increasingly expansive sphere of policy and practice.
Long non-coding RNA JPX correlates with poor prognosis and tumor progression in non-small-cell lung cancer by interacting with miR-145-5p and CCND2
Authors: Jin Meng , Ren Jie , Luo Miao , You Zhenxi , Fang Yuanyuan , Han Yin , Li Guangcai , Liu Huiguo 
Published: June 2019

Abstract
Emerging studies have shown that the aberrant expression and function of long non-coding RNAs (lncRNAs) are involved in carcinogenesis and the development of various cancers. The long noncoding RNA JPX (lncRNA JPX) on the X chromosome is an activator of X-inactive-specific transcript (XIST) and is a molecular switch for X-chromosome inactivation. However, the exact mechanism by which JPX acts in non-small-cell lung cancer (NSCLC) is not well studied. Here, through integrating clinical data and a series of functional experiments, we found that lncRNA JPX expression is significantly upregulated in NSCLC tissues compared with that in paired adjacent normal tissues from two independent datasets and significantly associated with a poor survival and other malignant phenotypes (tumor stage, tumor volume) of NSCLC. Furthermore, we elucidated that JPX functions as an oncogene in NSCLC-promoting cell proliferation and cell migration by affecting cell-cycle progression. Mechanistically, JPX upregulates cyclin D2 (CCND2) expression in a competing endogenous RNA mechanism by interacting with miR-145-5p, thus provoking the development and progression of NSCLC. These findings reveal the mechanism of X-chromosome lncRNA JPX and its core regulatory circuitry JPX/miR-145-5p/CCND2 in the development and progression of NSCLC, which bring us closer to an understanding of the molecular drivers of NSCLC.
Evaluating fMRI-Based Estimation of Eye Gaze During Naturalistic Viewing
Authors: Son Jake , Ai Lei , Lim Ryan , Xu Ting , Colcombe Stanley , Franco Alexandre Rosa , Cloud Jessica , LaConte Stephen , Lisinski Jonathan , Klein Arno , Craddock R Cameron , Milham Michael 
Published: June 2019

Abstract
The collection of eye gaze information during functional magnetic resonance imaging (fMRI) is important for monitoring variations in attention and task compliance, particularly for naturalistic viewing paradigms (e.g., movies). However, the complexity and setup requirements of current in-scanner eye tracking solutions can preclude many researchers from accessing such information. Predictive eye estimation regression (PEER) is a previously developed support vector regression-based method for retrospectively estimating eye gaze from the fMRI signal in the eye’s orbit using a 1.5-min calibration scan. Here, we provide confirmatory validation of the PEER method’s ability to infer eye gaze on a TR-by-TR basis during movie viewing, using simultaneously acquired eye tracking data in five individuals (median angular deviation &lt; 2°). Then, we examine variations in the predictive validity of PEER models across individuals in a subset of data (n = 448) from the Child Mind Institute Healthy Brain Network Biobank, identifying head motion as a primary determinant. Finally, we accurately classify which of the two movies is being watched based on the predicted eye gaze patterns (area under the curve = 0.90 ± 0.02) and map the neural correlates of eye movements derived from PEER. PEER is a freely available and easy-to-use tool for determining eye fixations during naturalistic viewing.
Clinical outcomes after implantation of quadripolar compared to bipolar left ventricular leads in patients undergoing cardiac resynchronization therapy: a systematic review and meta-analysis
Authors: Erath Julia W , Benz Alexander P , Hohnloser Stefan H , Vamos Mate 
Published: June 2019

Abstract

Aims
Some retrospective and prospective studies in heart failure patients with indication for cardiac resynchronization therapy (CRT) suggest better clinical outcomes for quadripolar (QP) left ventricular (LV) leads over bipolar (BP) leads. Although, lead failure remains an important safety concern, when using these more complex, novel electrodes. To evaluate safety and efficacy outcomes for QP vs. BP LV leads in patients receiving CRT.

Methods and results
We performed a comprehensive literature search through 2018 in PubMed, Cochrane Library, and Google Scholar databases to identify studies comparing patients with QP and BP LV CRT leads. A total of 12 studies were selected for analysis comprising 31 403 patients (QP lead: 22 429 patients; BP lead: 8974 patients). Eight studies examined the effects of CRT on survival. In these studies, use of QP electrodes was associated with significantly better survival compared to patients with BP LV leads (OR 0.61, 95% CI 0.50–0.76; P < 0.01). Clinical improval measured in New York Heart Association functional class (OR 0.59, 95% CI 0.34–1.01; P = 0.05) and hospitalization rates (OR 0.67, 95% CI 0.55–0.83; P < 0.01) were also improved in patients receiving QP leads. Lead malfunctions defined as LV lead failure resulting in lead deactivation (OR 0.57, 95% CI 0.34–0.98; P = 0.04) or LV lead dislodgement requiring LV lead replacement/repositioning (OR 0.48; 95% CI 0.31–0.75; P < 0.01) were more often encountered among patients with BP leads compared to patients with QP leads.

Conclusion
Our meta-analysis suggests distinct benefits of QP over BP electrodes in patients undergoing CRT.
N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study
Authors: Mullier Emeline , Roine Timo , Griffa Alessandra , Xin Lijing , Baumann Philipp S , Klauser Paul , Cleusix Martine , Jenni Raoul , Alemàn-Gómez Yasser , Gruetter Rolf , Conus Philippe , Do Kim Q , Hagmann Patric 
Published: June 2019

Abstract

Background
There is increasing evidence that redox dysregulation, which can lead to oxidative stress and eventually to impairment of oligodendrocytes and parvalbumin interneurons, may underlie brain connectivity alterations in schizophrenia. Accordingly, we previously reported that levels of brain antioxidant glutathione in the medial prefrontal cortex were positively correlated with increased functional connectivity along the cingulum bundle in healthy controls but not in early psychosis patients. In a recent randomized controlled trial, we observed that 6-month supplementation with a glutathione precursor, N-acetyl-cysteine, increased brain glutathione levels and improved symptomatic expression and processing speed.

Methods
We investigated the effect of N-acetyl-cysteine supplementation on the functional connectivity between regions of the cingulate cortex, which have been linked to positive symptoms and processing speed decline. In this pilot study, we compared structural connectivity and resting-state functional connectivity between early psychosis patients treated with 6-month N-acetyl-cysteine (n = 9) or placebo (n = 11) supplementation with sex- and age-matched healthy control subjects (n = 74).

Results
We observed that 6-month N-acetyl-cysteine supplementation increases functional connectivity along the cingulum and more precisely between the caudal anterior part and the isthmus of the cingulate cortex. These functional changes can be partially explained by an increase of centrality of these regions in the functional brain network.

Conclusions
N-acetyl-cysteine supplementation has a positive effect on functional connectivity within the cingulate cortex in early psychosis patients. To our knowledge, this is the first study suggesting that increased brain glutathione levels via N-acetyl-cysteine supplementation may improve brain functional connectivity.
Cryptococcus neoformans infection in Human Immunodeficiency Virus (HIV)-infected and HIV-uninfected patients at an inner-city tertiary care hospital in the Bronx
Authors: Yoon Hyun Ah , Felsen Uriel , Wang Tao , Pirofski Liise-anne 
Published: June 2019

AbstractCryptococcus neoformans causes life-threatening meningoencephalitis. Human immunodeficiency virus (HIV) infection is the most significant predisposing condition, but persons with other immunodeficiency states as well as phenotypically normal persons develop cryptococcosis. We retrospectively reviewed medical records of all patients with a diagnosis of cryptococcosis between 2005 and 2017 at our inner-city medical center in the Bronx, an epicenter of AIDS in New York City, and analyzed demographic data, clinical manifestations, laboratory findings, treatment, and mortality for these patients. In sum, 63% of the cases over this 12-year period occurred in HIV-infected patients. And 61% of the HIV-infected patients were non-adherent with antiretroviral therapy, 10% were newly diagnosed with AIDS, and 4% had unmasking cryptococcus-associated immune reconstitution inflammatory syndrome. The majority were Hispanic or black in ethnicity/race. HIV-uninfected patients (47/126) were older (P &lt; .0001), and the majority had an immunocompromising condition. They were less likely to have a headache (P = .0004) or fever (P = .03), had prolonged time to diagnosis (P = .04), higher cerebrospinal fluid (CSF) glucose levels (P = .001), less CSF culture positivity (P = .03), and a higher 30-day mortality (P = .03). Cases in HIV-uninfected patients were often unsuspected during their initial evaluation, leading to a delay in infectious diseases consultation, which was associated with mortality (P = .03). Our study indicates that HIV infection remains the most important predisposing factor for cryptococcosis despite availability of antiretroviral therapy and highlights potential missed opportunities for earlier diagnosis and differences in clinical and prognostic factors between HIV-infected and HIV-uninfected patients.
Nuclear-dominated accretion flows in two dimensions – II. Ejecta dynamics and nucleosynthesis for CO and ONe white dwarfs
Authors: Fernández Rodrigo , Margalit Ben , Metzger Brian D 
Published: June 2019

ABSTRACT
We study mass ejection from accretion discs formed in the merger of a white dwarf with a neutron star or black hole. These discs are mostly radiatively inefficient and support nuclear fusion reactions, with ensuing outflows and electromagnetic transients. Here we perform time-dependent, axisymmetric hydrodynamic simulations of these discs including a physical equation of state, viscous angular momentum transport, a coupled 19-isotope nuclear network, and self-gravity. We find no detonations in any of the configurations studied. Our global models extend from the central object to radii much larger than the disc. We evolve these global models for several orbits, as well as alternate versions with an excised inner boundary to much longer times. We obtain robust outflows, with a broad velocity distribution in the range 102–104 km s−1. The outflow composition is mostly that of the initial white dwarf, with burning products mixed in at the ${\lesssim } 10\rm {-}30{{\ \rm per\ cent}}$ level by mass, including up to ∼10−2 M⊙ of 56Ni. These heavier elements (plus 4He) are ejected within ≲ 40° of the rotation axis, and should have higher average velocities than the lighter elements that make up the white dwarf. These results are in broad agreement with previous one- and two-dimensional studies, and point to these systems as progenitors of rapidly rising (∼ few day) transients. If accretion on to the central BH/NS powers a relativistic jet, these events could be accompanied by high-energy transients with peak luminosities ∼1047–1050 erg s−1 and peak durations of up to several minutes, possibly accounting for events like CDF-S XT2.
An emission spectrum for WASP-121b measured across the 0.8–1.1 μm wavelength range using the Hubble Space Telescope
Authors: Mikal-Evans Thomas , Sing David K , Goyal Jayesh M , Drummond Benjamin , Carter Aarynn L , Henry Gregory W , Wakeford Hannah R , Lewis Nikole K , Marley Mark S , Tremblin Pascal , Nikolov Nikolay , Kataria Tiffany , Deming Drake , Ballester Gilda E 
Published: June 2019

Abstract
WASP-121b is a transiting gas giant exoplanet orbiting close to its Roche limit, with an inflated radius nearly double that of Jupiter and a dayside temperature comparable to a late M dwarf photosphere. Secondary eclipse observations covering the 1.1–$1.6\, \mu{\rm m}$ wavelength range have revealed an atmospheric thermal inversion on the dayside hemisphere, likely caused by high-altitude absorption at optical wavelengths. Here we present secondary eclipse observations made with the Hubble Space Telescope Wide Field Camera 3 spectrograph that extend the wavelength coverage from $1.1\, \mu{\rm m}$ down to $0.8\, \mu{\rm m}$. To determine the atmospheric properties from the measured eclipse spectrum, we performed a retrieval analysis assuming chemical equilibrium, with the effects of thermal dissociation and ionization included. Our best-fitting model provides a good fit to the data with reduced $\chi ^2_\nu =1.04$. The data diverge from a blackbody spectrum and instead exhibit emission due to H− shortward of $1.1\, \mu{\rm m}$. The best-fitting model does not reproduce a previously reported bump in the spectrum at $1.25\,\mu{\rm m}$, possibly indicating this feature is a statistical fluctuation in the data rather than a VO emission band as had been tentatively suggested. We estimate an atmospheric metallicity of $[{\rm M}/{\rm H}]= {1.09}_{-0.69}^{+0.57}$, and fit for the carbon and oxygen abundances separately, obtaining $[{\rm C}/{\rm H}]= {-0.29}_{-0.48}^{+0.61}$ and $[{\rm O}/{\rm H}]= {0.18}_{-0.60}^{+0.64}$. The corresponding carbon-to-oxygen ratio is ${\rm C/O} = 0.49_{-0.37}^{+0.65}$, which encompasses the solar value of 0.54, but has a large uncertainty.
The abundance and physical properties of O vii and O viii X-ray absorption systems in the EAGLE simulations
Authors: Wijers Nastasha A , Schaye Joop , Oppenheimer Benjamin D , Crain Robert A , Nicastro Fabrizio 
Published: June 2019

Abstract
We use the EAGLE cosmological, hydrodynamical simulations to predict the column density and equivalent width distributions of intergalactic O vii ($E=574 \, \rm {eV}$) and O viii ($E=654 \, \rm {eV}$) absorbers at low redshift. These two ions are predicted to account for $40 \, \hbox{ per cent}$ of the gas-phase oxygen, which implies that they are key tracers of cosmic metals. We find that their column density distributions evolve little at observable column densities from redshift 1 to 0, and that they are sensitive to active galactic nucleus feedback, which strongly reduces the number of strong (column density $N \gtrsim 10^{16} \, \rm {cm}^{-2}$) absorbers. The distributions have a break at $N \sim 10^{16}\, \rm {cm}^{-2}$, corresponding to overdensities of ∼102, likely caused by the transition from sheet/filament to halo gas. Absorption systems with $N \gtrsim 10^{16} \, \rm {cm}^{-2}$ are dominated by collisionally ionized O vii and O viii, while the ionization state of oxygen at lower column densities is also influenced by photoionization. At these high column densities, O vii and O viii arising in the same structures probe systematically different gas temperatures, meaning their line ratio does not translate into a simple estimate of temperature. While O vii and O viii column densities and covering fractions correlate poorly with the H i column density at ${N}_{\rm {H}\, \rm {I}} \gtrsim 10^{15} \, \rm {cm}^{-2}$, O vii and O viii column densities are higher in this regime than at the more common, lower H i column densities. The column densities of O vi and especially Ne viii, which have strong absorption lines in the UV, are good predictors of the strengths of O vii and O viii absorption and can hence aid in the detection of the X-ray lines.
Enhancer-mediated enrichment of interacting JMJD3–DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription
Authors: Argaud Deborah , Boulanger Marie-Chloé , Chignon Arnaud , Mkannez Ghada , Mathieu Patrick 
Published: June 2019

AbstractENPP2, which encodes for the enzyme autotaxin (ATX), is overexpressed during chronic inflammatory diseases and various cancers. However, the molecular mechanism involved in the ENPP2 transcription remains elusive. Here, in HEK 293T cells, we demonstrated that lipopolysaccharide (LPS) increased the transcription process at ENPP2 locus through a NF-кB pathway and a reduction of H3K27me3 level, a histone repressive mark, by the demethylase UTX. Simultaneously, the H3K27me3 demethylase JMJD3/KDM6B was recruited to the transcription start site (TSS), within the gene body and controlled the expression of ENPP2 in a non-enzymatic manner. Mass spectrometry data revealed a novel interaction for JMJD3 with DDX21, a RNA helicase that unwinds R-loops created by nascent transcript and DNA template. Upon LPS treatment, JMJD3 is necessary for DDX21 recruitment at ENPP2 locus allowing the resolution of aberrant R-loops. CRISPR-Cas9-mediated deletion of a distant-acting enhancer decreased the expression of ENPP2 and lowered the recruitment of JMJD3–DDX21 complex at TSS and its progression through the gene body. Taken together, these findings revealed that enhancer-mediated enrichment of novel JMJD3–DDX21 interaction at ENPP2 locus is necessary for nascent transcript synthesis via the resolution of aberrant R-loops formation in response to inflammatory stimulus.