bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of an integrated diabetes care package at primary healthcare facilities: a cluster randomised trial in Pakistan
Authors: Khan Muhammad Amir , Walley John D , Khan Nida , Hicks Joseph , Ahmed Maqsood , Khan Shaheer Ellahi , Khan Muhammad Ahmar , Khan Haroon Jehangir , Harries Anthony D 
Published: December 2018

BackgroundThere were an estimated 7 million people living with diabetes in Pakistan in 2014, and this is predicted to reach 11.4 million by 2030.AimTo assess if an integrated care package can achieve better control of diabetes.Design & settingThe pragmatic cluster randomised controlled trial (cRCT) was conducted from December 2014–June 2016 at 14 primary healthcare facilities in Sargodha district. Opportunistic screening, diagnostic testing, and patient recording processes were introduced in both the control 'testing, treating, and recording' (TTR) arm, and the intervention 'additional case management' (ACM) arm, which also included a clinical care guide and pictorial flipbook for lifestyle education, associated clinician training, and mobile phone follow-up.MethodClinics were randomised on a 1:1 basis (sealed envelope lottery method) and 250 patients recruited in the ACM arm and 245 in the TTR-only arm (age ≥25 years and HbA1c >7%). The primary outcome was mean change in HbA1c (%) from baseline to 9-month follow-up. Patients and staff were not blinded.ResultsThe primary outcome was available for n = 238/250 (95.2%) participants in the ACM arm and n = 219/245 (89.4%) participants in the TTR-only arm (all clusters). Cluster level mean outcome was -2.26 pp (95% confidence intervals [CI] = -2.99 to -1.53) for the ACM arm, and -1.44 pp (95% CI = -2.34 to -0.54) for the TTR-only arm. Cluster level mean ACM–TTR difference (covariate-unadjusted) was -0.82 pp (95% CI = -1.86 to 0.21; P = 0.11).ConclusionThe ACM intervention in public healthcare facilities did not show a statistically significant effect on HbA1c reduction compared to the control (TTR-only) arm. Future evaluation should assess changes after a longer follow-up period, and minimal care enhancement in the comparator (control) arm.
Secular Transport during Disk Dispersal: The Case of Kepler-419
Authors: Petrovich Cristobal , Wu Yanqin , Ali-Dib Mohamad 
Published: December 2018

Abstract
Due to fortuitous circumstances, the two giant planets around Kepler-419 have well characterized three-dimensional orbits. They are nearly coplanar to each other; the inner one has a large eccentricity (≃0.82); and the apses of the two orbits librate around anti-alignment. Such a state defies available proposals for large eccentricities. We argue that it is instead uniquely produced by a decaying protoplanetary disk. When the disk was massive, its precessional effect on the planets forced the two apses to center around an anti-aligned state. And as the disk is gradually eroded, the pair of planets are adiabatically transported to a new state where most of the eccentricity (or rather, the angular momentum deficit) is transferred to the inner planet, and the two apses are largely anti-aligned. During this transport, any initial mutual inclination may be reduced or enhanced; either may be compatible with the current constraints. So a primordial disk can drive up planet eccentricities both in resonant planet pairs (as has been shown for GJ 876) and in secularly-interacting, non-resonant pairs. The mechanism discussed here may be relevant for forming hot Jupiters and for explaining the observed eccentricities of warm and cold giant planets.
Multi-band Polarimetry of the Lunar Surface. II. Grain Size Evolutionary Pathway
Authors: Jeong Minsup , Choi Young-Jun , Kim Sungsoo S. , Kim Il-Hoon , Shkuratov Yuriy. G. , Yang Hongu 
Published: December 2018

Abstract
To understand grain size evolution on the lunar surface in detail, we analyze the distribution of the average grain size

for the lunar near side obtained by Jeong et al. Furthermore, we analyze the polarimetric properties of the regolith simulants SiC and JSC-1A in a laboratory. We find two characteristics of grain size evolution on the Moon. First, the lunar regolith has evolved on a specific evolutionary pathway in

space. Here, Φ is defined as the ratio of the perpendicular (

) and parallel (

) components of the reflectance. Second, we also find that the evolutionary pathway depends on the FeO abundance and selenographic latitude of the surface. The dependence on the FeO content seems to result from the different resistance to comminution of regolith materials, and the dependence on the latitude seems to result from differences in the resurfacing environment. We present the probable causes of these characteristics of grain size evolution on the lunar surface.
Magnetic Helicity Condensation and the Solar Cycle
Authors: Mackay Duncan H. , DeVore C. Richard , Antiochos Spiro K. , Yeates Anthony R. 
Published: December 2018

Abstract
Solar filaments exhibit a global chirality pattern where dextral/sinistral filaments, corresponding to negative/positive magnetic helicity, are dominant in the northern/southern hemisphere. This pattern is opposite to the sign of magnetic helicity injected by differential rotation along east–west oriented polarity inversion lines, posing a major conundrum for solar physics. A resolution of this problem is offered by the magnetic helicity-condensation model of Antiochos. To investigate the global consequences of helicity condensation for the hemispheric chirality pattern, we apply a temporally and spatially averaged statistical approximation of helicity condensation. Realistic magnetic field configurations in both the rising and declining phases of the solar cycle are simulated. For the helicity-condensation process, we assume convective cells consisting of positive/negative vorticities in the northern/southern hemisphere that inject negative/positive helicity. The magnitude of the vorticity is varied as a free parameter, corresponding to different rates of helicity injection. To reproduce the observed percentages of dominant and minority filament chiralities, we find that a vorticity of magnitude 2.5 × 10−6 s−1 is required. This rate, however, is insufficient to produce the observed unimodal profile of chirality with latitude. To achieve this, a vorticity of at least 5 × 10−6 s−1 is needed. Our results place a lower limit on the small-scale helicity injection required to dominate differential rotation and reproduce the observed hemispheric pattern. Future studies should aim to establish whether the helicity injection rate due to convective flows and/or flux emergence across all latitudes of the Sun is consistent with our results.
De l’utilisation du contre-transfert (CT) en thérapie familiale
Authors: Eiguer Alberto 
Published: December 2018

Dans cet article, l’auteur se propose de travailler le concept de contre-transfert dans son application à la thérapie familiale psychanalytique (TFP) ainsi que de couple (TPC). Il part de l’idée de Winnicott, selon laquelle le thérapeute n’est pas seulement désigné comme un objet significatif des patients, mais qu’il est attendu dans une écoute, une disponibilité et un accueil afin de « se faire utiliser ». La dissymétrie thérapeutes-patient y devient d’autant plus intéressante. L’auteur revisite les apports de différents précurseurs pour s’intéresser à ce que le CT a de spécifique auprès des familles en thérapie ; le roman familial y joue un rôle singulier, le thérapeute étant désigné comme un être non-humain ou l’autre du parent, géniteur, formateur, grand parent, objet transgénérationnel. Le thérapeute va ainsi éprouver ce qui la famille ne peut se représenter, les incertitudes, le désarroi, la sidération. L’auteur étudie également les virtualités de l’intertransfert entre cothérapeutes ; l’intertransfert devient un modèle d’élaboration qui fertilise le groupe en traitement sans que l’on s’en aperçoive. Le transfert peut s’y diversifier tout en se référant à une totalité groupale. Deux vignettes cliniques illustrent ces idées.
Les questionnaires d’évaluation des fonctionnaires allemands pendant le nazisme et lors de la dénazification
Authors: Vincent Marie-Bénédicte 
Published: December 2018

L’article examine des questionnaires d’évaluation de fonctionnaires allemands membres de l’organisation nazie du Reichsbund der Deutschen Beamten entre 1933 et 1945, ainsi que des questionnaires d’épuration dans l’immédiat après-guerre jusqu’en 1948, en réinsérant cette séquence dans une histoire longue de la « fonction publique professionnelle ». Il s’agit de réfléchir aux continuités dans les pratiques et les formes de l’évaluation et de la surveillance des fonctionnaires dans une période de changements politiques radicaux avec les deux césures de 1933 et 1945.
Des connaissances aux décisions : la mise en œuvre des directives européennes sur l’eau douce et marine
Authors: Bouleau Gabrielle , Carter Caitríona , Thomas Arnaud 
Published: December 2018

Cet article compare l’effet d’une forme de « participation performative » sur la nature et l’usage de savoirs lors de la mise en œuvre de la Directive-cadre sur l’eau (DCE) par comparaison avec la mise en œuvre de la Directive-cadre stratégie milieu marin (DCSMM) en Nouvelle Aquitaine. Les deux directives promeuvent une approche écosystémique à l’égard de la participation, mais donnent peu d’éléments sur sa mise en pratique. Pour saisir comment les acteurs ont agi, d’une façon comparative, nous mobilisons un nouveau cadre conceptuel (les 4A) qui distingue : (1) l’Acquisition des connaissances et des ressources politiques, (2) leur Agrégation, (3) leur usage dans l’Argumentation de la décision et (4) leur Accumulation. Les résultats montrent comment les différentes formes de médiation en lien avec une approche écosystémique peuvent construire deux nouveaux types de « publics » dans la gouvernance de l’eau.
Légitimité des savoirs citoyens dans la gestion participative des territoires de l’eau
Authors: Crémin Émilie , Linton Jamie , Jacquin Natacha , Perrin Jacques-Aristide 
Published: December 2018

Alors que la participation du public est devenue une prescription réglementaire, nous questionnons ici la légitimité et la place accordée aux savoirs citoyens dans la gestion participative des territoires de l’eau. Pour répondre à ces questions, cet article présente un projet de recherche participative impliquant des habitants de la rivière Dordogne. Plusieurs outils ont été mobilisés (ateliers, cartes, entretiens) pour engager la participation du public, identifier et comprendre la construction des savoirs citoyens. L’ensemble de cette recherche a fait l’objet d’un tournage et a donné lieu à la réalisation d’un film utilisé, une fois monté, comme un outil de recherche. Les séances de projection ont permis de poursuivre le débat. L’analyse des données produites met en évidence une pluralité de savoirs et une diversité d’usages de la rivière que nous présentons dans l’article. Néanmoins, le sentiment d’attachement à cet espace contribue à la construction d’une identité riveraine commune. Face à une gestion dominée par les « savoirs experts », le recours aux savoirs des citoyens et leurs mobilisations dans des outils participatifs permettraient de mieux politiser des enjeux concernant l’aménagement de la Dordogne. La prise en compte légitime de ces savoirs permettrait d’assurer l’appropriation des territoires de l’eau par les populations riveraines.
Literature and Psychedelics: a Pharmacological Subversion of Authentic Life. With an example from William S. Burroughs
Authors: Patoine Pierre-Louis 
Published: December 2018

Nous explorons dans cet article la manière dont la « vie authentique » se constitue à travers un style de conscience normé, que la pratique de la littérature et de certains psychotropes conteste. Cette exploration se consacre plus précisément aux hallucinogènes dits « psychédéliques » et à The Wild Boys , que William S. Burroughs publie en 1971. Cette analyse comparée s’appuie sur la notion platonicienne de pharmakon , et sur la prise en compte des spécificités neurophysiologiques de la littérature et des substances psychédéliques. Nous concluons en observant que l’usage que fait Burroughs de l’ekphrasis agit comme une drogue psychédélique, perturbant la conscience séquentielle habituelle et libérant la sensation et le désir des contraintes normatives de la production et de la reproduction promues à l’époque moderne.
Tomographic and Biomechanical Scheimpflug Imaging for Keratoconus Characterization: A Validation of Current Indices
Authors: Steinberg Johannes , Siebert Marlene , Katz Toam , Frings Andreas , Mehlan Juliane , Druchkiv Vasyl , Bühren Jens , Linke Stephan J. 
Published: December 2018

PURPOSE:
To analyze the potential benefit of the newly developed Tomography and Biomechanical Index (TBI) for early keratoconus screening.

METHODS:

In this retrospective study, the discriminatory power of the corneal tomography Belin/Ambrósio Enhanced Ectasia Display (BAD-D) index and the newly developed Corvis Biomechanical Index (CBI) and TBI to differentiate between normal eyes, manifest keratoconus eyes (KCE), very asymmetric keratoconus eyes with ectasia (VAE-E), and their fellow eyes with either regular topography (VAE-NT) or regular topography and tomography (VAE-NTT) were analyzed by applying the
t
test (for normal distribution), Wilcoxon matched-pairs test (if not normally distributed), and receiver operating characteristic curve (ROC). The DeLong test was used to compare the area under the ROC (AUROC). Further, the cut-offs of the analyzed indices presented in a study by Ambrósio et al. from 2017 were applied in the study population to enable a cross-validation in an independent study population.

RESULTS:

All indices demonstrated a high discriminative power when comparing normal and advanced keratoconus, which decreased when comparing normal and VAE-NT eyes and further when analyzing normal versus VAE-NTT eyes. The difference between the AUROCs reached a statistically significant level when comparing TBI versus BAD-D analyzing normal versus all included keratoconic eyes (
P
= .02). The TBI presented with the highest AUROCs throughout all conducted analyses when comparing different keratoconus stages, although not reaching a statistically significant level. Applying the cut-offs presented by Ambrósio et al. to differentiate between normal and VAE-NT in the study population, the accuracy was reproducible (accuracy in our study population with an optimized TBI cut-off: 0.72, with the cut-off defined by Ambrósio et al. 0.67).

CONCLUSIONS:
The TBI enables karatoconus screening in topographical and tomographical regular keratoconic eyes. To further improve the screening accuray, prospective studies should be conducted.

[
J Refract Surg
. 2018;34(12):840–847.]
Outcomes for Hyperopic LASIK With the MEL 90
®
Excimer Laser
Authors: Reinstein Dan Z. , Carp Glenn I. , Archer Timothy J. , Day Alexander C. , Vida Ryan S. 
Published: December 2018

PURPOSE:
To report the outcomes of laser in situ keratomileusis (LASIK) for hyperopia using the Triple-A ablation profile with the MEL 90 excimer laser (Carl Zeiss Meditec, Jena, Germany).

METHODS:
This retrospective analysis included 1,383 eyes treated by LASIK for hyperopia using the Triple-A ablation profile with the MEL 90 at London Vision Clinic, London, United Kingdom, between September 2013 and December 2016. Inclusion criteria were attempted hyperopic correction of +0.25 diopters (D) or higher and corrected distance visual acuity (CDVA) of 20/40 or better. Patients were observed for 1 year after surgery. Standard outcomes analysis was performed.

RESULTS:

One-year data were available for 1,350 (97%) eyes. Mean attempted spherical equivalent refraction (SEQ) was +2.77 ± 1.34 D (range: +0.13 to +6.50 D) and mean cylinder was −0.67 ± 0.66 D (range: 0.00 to −5.00 D). Mean age was 54 ± 11 years (range: 21 to 75 years), and 57% were female. Postoperative spherical equivalent was ±0.50 D in 73% and ±1.00 D in 93% of eyes. Uncorrected distance visual acuity was 20/20 or better in 75% of eyes, relative to 93% with preoperative CDVA of 20/20 or better. One line of CDVA was lost in 17% of eyes and two lines were lost in 0.6% of eyes. There was a clinically insignificant but statistically significant increase (
P
< .01) in contrast sensitivity at 3 and 6 cycles per degree (cpd) and no change for 12 and 18 cpd.

CONCLUSIONS:
LASIK for hyperopia with the MEL 90 excimer laser was found to satisfy accepted criteria for safety, efficacy, and stability.

[
J Refract Surg
. 2018;34(12):799–808.]
Safety and Efficacy of a New Phakic Posterior Chamber IOL for Correction of Myopia: 3 Years of Follow-up
Authors: Vasavada Viraj , Srivastava Samaresh , Vasavada Shail A. , Sudhalkar Aditya , Vasavada Abhay R. , Vasavada Vaishali A. 
Published: December 2018

PURPOSE:
To evaluate the outcomes of a new posterior chamber phakic intraocular lens (IPCL; Care Group, Baroda, India) to correct myopia.

METHODS:
This prospective, observational case series included 30 eyes undergoing implantation of the IPCL for high myopia (> −8.00 diopters [D]). Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, refraction, vault, endothelial cell loss, and adverse events were evaluated 3 years after implantation of the IPCL for high myopia.

RESULTS:

The mean spherical equivalent decreased from −16.50 ± 5.62 D preoperatively to −0.89 ± 1.27 D at 3 years. The mean UDVA and CDVA were 0.38 ± 0.21 and 0.24 ± 0.09 logMAR. No eye lost any lines and 49% of eyes gained one line or more of CDVA. One eye (3.3%) developed anterior subcapsular cataract, but did not require cataract surgery at 3 years of follow-up. Two eyes (6.6%) developed a mild transient increase in intraocular pressure, which required topical medication only for 3 months. The percentage of endothelial cell loss at 3 years was 9.73% ± 6.72%. The IPCL vault tended to reduce with time, from a mean of 626.66 ± 188.98
μ
m at 1 month to 540.22 ± 210.76
μ
m at 3 years. No vision-threatening complications occurred.

CONCLUSIONS:
Implantation of the new posterior chamber phakic IOL is an effective alternative to correct high myopia, showing good outcomes at 3 years.

[
J Refract Surg
. 2018;34(12):817–823.]
Monolinguisme, plurilinguisme et translinguisme chez Paul Celan
Authors: Weissmann Dirk 
Published: December 2018

Cet article se propose d’aborder le problème du plurilinguisme dans l’œuvre du poète germanophone Paul Celan (1920-1970), en examinant la genèse de son poème « Huhediblu », publié en 1963 dans le recueil Die Niemandsrose (La Rose de personne). Si la version publiée du poème comporte un certain nombre d’éléments hétérolingues, l’examen des brouillons permet de montrer que le plurilinguisme a joué un rôle éminemment créateur dans l’écriture de ce texte. Celui-ci est en effet d’abord né en marge d’extraits de poèmes en langue étrangère, et sa genèse repose sur de complexes processus translingues. Le titre même du poème, néologisme condensant la forme et le fond du texte, est le résultat d’une rencontre, d’une confrontation, d’une hybridation entre les langues. On peut ainsi parler de l’existence d’une véritable trame plutilingue qui a présidé à la naissance de ce poème, trame qu’on suivra à travers les différentes étapes de sa genèse.
Vers une génétique de la critique : le cas de Georges Poulet
Authors: Valentine Colton 
Published: December 2018

Traditionnellement, la critique génétique retrace les métamorphoses d’un ouvrage littéraire, voire poétique ou fictif, à travers ses brouillons et ses variantes publiées. Dans « Vers une génétique de la critique : le cas de Georges Poulet », on s’interroge sur les conséquences d’une adaptation de cette méthode aux ouvrages de la critique littéraire. À cette fin, on aborde l’étude du cas de Georges Poulet, l’écrivain belge connu pour ses Études sur le temps humain. En s’appuyant sur la richesse des archives au Fonds Georges Poulet à Berne, on cherche, premièrement, à codifier les étapes de la « procédure critique » de Poulet : le recueil de citations, leur catégorisation thématique, et leur intégration dans l’écriture du critique. Ensuite, on constate que cette procédure soutient et explique certains principes idiosyncratiques de sa « critique d’identification », comme, par exemple, le retrait du contexte de la citation et des distinctions génériques, ainsi que la supposition que chaque œuvre est unifiée de façon organique. Finalement, on explore la façon dont cette praxis elle-même autorise une telle approche génétique de l’œuvre de Poulet. En conclusion, on réfléchit à la mesure dans laquelle ce cas pourrait fournir un socle théorique pour d’autres études de ce genre – et on se demande si une « génétique de la critique » ajoute par définition un mandat de mimétisme : une exigence d’imitation par rapport au cadre théorique de l’œuvre sondée.
Complement Activation Occurs at the Surface of Platelets Activated by Streptococcal M1 Protein and This Results in Phagocytosis of Platelets
Authors: Palm Frida , Sjöholm Kristoffer , Malmström Johan , Shannon Oonagh 
Published: December 2018

Abstract
Platelets circulate the bloodstream and principally maintain hemostasis. Disturbed hemostasis, a dysregulated inflammatory state, and a decreased platelet count are all hallmarks of severe invasive Streptococcus pyogenes infection, sepsis. We have previously demonstrated that the released M1 protein from S. pyogenes activates platelets, and this activation is dependent on the binding of M1 protein, fibrinogen, and M1-specific IgG to platelets in susceptible donors. In this study, we characterize the M1-associated protein interactions in human plasma and investigate the acquisition of proteins to the surface of activated platelets and the consequences for platelet immune function. Using quantitative mass spectrometry, M1 protein was determined to form a protein complex in plasma with statistically significant enrichment of fibrinogen, IgG3, and complement components, especially C1q. Using flow cytometry, these plasma proteins were also confirmed to be acquired to the platelet surface, resulting in complement activation on M1-activated human platelets. Furthermore, we demonstrated an increased phagocytosis of M1-activated platelets by monocytes, which was not observed with other physiological platelet agonists. This reveals a novel mechanism of complement activation during streptococcal sepsis, which contributes to the platelet consumption that occurs in sepsis.
No desarranjo do arranjo: processos formativos em experimentação com geometrias
Authors: Rotondo Margareth Sacramento , Dutra Leandro Barreto 
Published: December 2018

Uma pesquisa em Educação Matemática apostou numa política cognitiva inventiva e no pensamento não dogmático como modo de atentar-se à variância presente no imanente do viver. Trouxe experimentação com dispositivo do circo - tecido aéreo preso em um abacateiro – que fez nascer geometrias e existires. Barbantes e cadernos e fotos fizeram arrastar língua e matemática, que gaguejaram. Modos de operar com geometrias inventadas nasceram no desarranjo do arranjo. Junto a isto, processos formativos em invenção com tecido, com barbante, com risos, com riscos, com saber-sabor produzindo-se com geometrias. Adolescentes e professores e professoras em formação arriscando-se no perder-se de seus territórios, no tombamento de seus rostos e suas tantas significações na processualidade da formação, inventam-se com geometrias inventadas. O mapeamento da processulidade vívida destes processos formativos compuseram-se junto a uma política de narratividade que banhou-se em afetos do jogo Branco-Augusto da palhaçaria e das filosofias da diferença.