bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of A Novel GLP-1R Ligand for PET Imaging of Prostate Cancer
Authors: Yue Yuanyuan , Xu Yuping , Huang Lirong , Pan Donghui , Bai Zhicheng , Wang Lizhen , Yang Runlin , Yan Junjie , Song Huizhu , Li Xiaotian , Yang Min 
Published: August 2018

Background:Glucagon-like peptide 1 receptor (GLP-1R) is an important biomarker for diagnosis and therapy of the endocrine cancers due to overexpression. Recently, in human prostate cancer cell lines the receptor was also observed, therefore it may be a potential target for the disease. 18F-Al-NOTA-MAL-Cys39- exendin-4 holds great promise for GLP-1R. Therefore, the feasibility of the 18F-labeled exendin-4 analog for prostate cancer imaging was investigated.Methods:New probe 18F-Al-NOTA-MAL-Cys39-exendin-4 was made through one-step fluorination. Prostate cancer PC3 cell xenograft model mice were established to primarily evaluate the imaging properties of the tracer via small animal PET studies in vivo. Pathological studies and Western Blots were also performed.Results:PC-3 prostate xenografts were clearly imaged under baseline conditions. At 30 and 60 min postinjection, the tumor uptakes were 2.90±0.41%ID/g and 2.26±0.32 %ID/g respectively. The presence of cys39-exendin-4 significantly reduced the tumor uptake to 0.82±0.10 %ID/g at 60 min p.i. Findings of ex vivo biodistribution studies were similar to those of in vivo PET imaging. The tumors to blood and muscles were significantly improved with the increase of time due to rapid clearance of the tracer from normal organs. Low levels of radioactivity were also detected in the GLP-1R positive tumor and normal organs after coinjection with excessive unlabeled peptides. Immunohistochemistry and Western Blots results confirmed that GLP-1R was widely expressed in PC-3 prostate cancers.Conclusion:18F-Al labeled exendin-4 analog might be a promising tracer for in vivo detecting GLP-1R positive prostate cancer with the advantage of facile synthesis and favorable pharmacokinetics. It may be useful in differential diagnosis, molecularly targeted therapy and prognosis of the cancers.
ISLAMIC BANK AND SHARIA BUSINESS UNIT IN INDONESIA: A COMPARISON ON INTELLECTUAL CAPITAL DISCLOSURE PRATICES
Authors: Ulum Ihyaul , Amdini Ismi’ Nor , Setyawan Setu , Mohamed Nafsiah 
Published: August 2018

This study aims to compare the intellectual capital disclosures (ICD) in annual reports between Islamic Banks and Sharia Business Unit in 2015. Intellectual capital (ICD) is divided into three main components namely; Human capital, Structural capital and relational capital. The components used in this study is the ICD-In framework written by Ulum (2015) which consists of 36 items of intellectual capital. This study uses purposive sampling to determine the sample of Islamic bank and Sharia business units registered in Bank Indonesia in 2015, with a sample of 34 banks. The results indicate that there was a difference practices on intellectual capital disclosures of Islamic banks and Sharia business unit. Islamic banks disclosed on IC higher than Sharia business unit.
Protestantismo na fronteira operária brasileira: a solidariedade fiel na relação com o operariado brasileiro - 1963
Authors: Bousfield André Augusto 
Published: August 2018

Este artigo visa apresentar um missionário estadunidense que trabalhara na década de 1940 nos EUA com operários mineiros de carvão mineral, bem como com suas famílias. Esse missionário, Richard Charles Smith, também trabalhou nesse mesmo perfil no Brasil no início da década de 1960. Embora membro da PCUSA, no Brasil trabalhara junto com a Igreja Presbiteriana do Brasil (IPB) na região carbonífera de Santa Catarina (1960-1963) e posteriormente por um ano e meio na cidade de São Paulo. Defendemos a tese de que a teologia de Richard C. Smith, intitulada Solidariedade Fiel, é filha direta do Evangelho Social estadunidense, e que ao se deparar com a realidade brasileira, percebeu um problema já percebido em outros contextos de industrialização do mundo: um distanciamento e uma desconfiança dos protestantismos históricos em relação ao operário comum, suas famílias e seus dilemas. No Brasil, Smith bradou esses alertas no principal veículo de comunicação da IPB: o jornal Brasil Presbiteriano. O título do artigo: A Igreja na fronteira operária, e um dos subtemas ligados ao contexto brasileiro especificamente: Províncias abandonadas do protestantismo. Neste artigo, apresentamos uma análise desses alertas de Richard C. Smith à IPB e ao mundo protestante brasileiro, sobretudo em relação ao seu distanciamento da classe trabalhadora, e a percepção consciente dessa classe diante desse abandono.
Um diálogo possível entre teologia e sociedade: assistência espiritual nos cuidados em final de vida
Authors: Chemin Marcia Regina Chizini , Souza Waldir 
Published: August 2018

Desafios se apresentam à Teologia na esteira do desenvolvimento tecnológico, em especial, devido às consequências que levam o ser humano mesmo gravemente doente a viver por mais tempo. A longevidade em si, também aumentada pelos efeitos do desenvolvimento das ciências médicas, traz à cena cotidiana cada vez mais idosos com doenças crônico-degenerativas. Todos, a seu modo, apresentarão quadro de doença crônica, que se estenderá por anos, e, muito provavelmente, ao entrarem em fase final de doença, serão pacientes elegíveis aos Cuidados Paliativos. A morte não se dará em um instante inesperado, ao contrário, será esperada e prevista. A vida que se alonga apresenta uma nova realidade: experiências humanas que não existiam no passado. Assim, uma nova reflexão teológica surge provocada pela realidade experimentada. A questão está posta à Teologia, pois implica o ser humano, sua espiritualidade e sua busca por sentido de viver. O cuidado humanizado e integral que respeite o protagonismo do paciente é preocupação da Bioética no auxílio à prática do cuidado médico. A partir de breve revisão bibliográfi ca, observou-se que há confusão entre conceitos determinantes como religião e espiritualidade, e que há necessidade de formar assistentes espirituais para atuarem no cuidado aos enfermos como facilitadores de tratamento.
PIBID de Ensino Religioso: uma proposta de educação para relações de equidade em contextos de diversidade religiosa
Authors: Rodrigues Elisa , De Oliveira Tania Alice 
Published: August 2018

O artigo apresenta o Programa Institucional de Bolsa de Iniciação à Docência (PIBID) como política pública de formação de docentes, que na Universidade Federal de Juiz de Fora (UFJF) promoveu o subprojeto Ensino Religioso, proposto pelo Departamento de Ciência da Religião responsável pela licenciatura em Ensino Religioso. Esse subprojeto (2014-2018) aborda o tema religião na escola pública e contribui para a formação de futuros docentes. Além disso, colabora para uma discussão sobre as diferentes tradições religiosas brasileiras em perspectiva compreensiva. A partir da concepção de que as tradições religiosas enquanto área cognoscível também contribuem para explicar a realidade, o PIBID intenciona oferecer novas fontes de conhecimento fundamentadas pelo respeito à laicidade da escola pública.
Transdisciplinaridade, o campo das Ciências da Religião e sua aplicação ao Ensino Religioso
Authors: Aragão Gilbraz , Souza Mailson 
Published: August 2018

O Ensino Religioso pode desempenhar um papel importante na construção de culturas pluralistas e sociedades democráticas, desde que aprofunde seus fundamentos e desenvolva metodologias apropriadas. Procurando colaborar nesse sentido, o presente ensaio demonstra que uma postura transdisciplinar ajuda a criar conteúdo dialógico no campo das Ciências da Religião e a traduzir pedagogicamente, em processos de aprendizagem libertários, tais conhecimentos religiosos para o Ensino Religioso laico, plural e republicano. A área de conhecimento das Ciências da Religião surgiu para interpretar as experiências de sagrado, de forma aberta à complementariedade das disciplinas científicas e alicerçada sobre uma epistemologia das controvérsias. Em uma linha de desenvolvimento da metodologia interdisciplinar, a transdisciplinaridade pode desenvolver esses fundamentos científico-culturais, construindo conhecimentos através e além das ciências, engendrando uma atitude transcultural e transreligiosa em nossos estudos de religião, que é muito apropriada para sua aplicação ao Ensino Religioso
Evaluation of Suspended Matter less than 10 µm and Cardiovascular and Respiratory Diseases: in Urmia City, 2015
Authors: Entezar Mahdi Rasool , Ghojogh Mousa Ghelichi , Kargar Hojjat , Minaee Mehr Saeed 
Published: August 2018

Introduction: Air pollution induced by human activities is one of major challenges faced by Iran, as well as the world . The AirQ model was used to evaluate the cardiovascular and respiratory diseases attributable to the exposure to suspended particles of less than 10 µm in Urmia city of West Azerbaijan Province, Iran, in 2015. Materials and Methods: This descriptive-analytic study was conducted in Urmia in 2015. The hourly data of the PM10 (particle matter up to 10 µm) pollutant were extracted as the raw material from the Environmental Health Center. The health effects of suspended particles of less than 10 µm were estimated by statistical analysis using the World Health Organization’s AirQ model.Results: According to the results concentration of PM10 was higher in the cold seasons compared with the warm seasons. The annual average of PM10 concentration was 3.9 times higher than that prescribed as per the standards of clean air in Iran. In addition, the cumulative numbers of cardiovascular and respiratory diseases in the city of Urmia in the median estimate were 287 and 744 cases, respectively. Conclusion: As a consequently, air pollution in the Urmia city has contributed significantly to the rate of hospitalizations and deaths of people in 2015. Therefore, authorities should make appropriate, sustainable, and applicable strategies based on comprehensive research to control the Urmia air pollution crisis.
Evaluasi Kinerja Alumni Pelatihan Kepemimpinan Menggunakan Sistem Informasi Dalam Jaringan: Temuan Awal
Authors: Suparman Rahmat , Lucita Gina 
Published: August 2018

Evaluation is an important aspect of leadership training management since the result of evaluation can be used as inputs for future improvement. However, the current practices of training evaluation are dominated by in-training evaluation to measure the participants’ reaction and learning. Training institutions are still reluctant to conduct post training evaluation to find out the performance of the alumni as the impact and benefit of leadership training. This article attemtps to describe the result of post leadership training evaluation, focusing on describing the alumni career and performance using online information system. From the operational point of view, this study found out that using information system is really helpful in managing evaluation data faster and more acurately. The findings of this study indicate that the majority of the respondents admitted their performances have improved after the training as indicated by the continuation of their innovation projects.
Key Words: Leadership Training, Evaluating Training Impact, Information System
AbstrakEvaluasi adalah tahapan penting dalam manajemen pelatihan kepemimpinan karena hasil evaluasi dapat menjadi input berharga untuk proses perbaikan. Namun, praktek evaluasi pelatihan yang saat ini dilakukan masih terbatas pada evaluasi saat pelatihan untuk menilai reaksi dan pencapaian kompetensi peserta. Lembaga pelatihan masih jarang melaksanakan evaluasi pascapelatihan untuk menilai kinerja alumni pelatihankepemimpinan. Tulisan ini mencoba memaparkan hasil evaluasi pascapelatihan kepemimpinan dengan fokus kepada karir dan kinerja para alumni dengan menggunakan bantuan teknologi informasi dalam jaringan (daring). Dari sisi proses pelaksanaan evaluasi, data menunjukkan bahwa sistem informasi daring dapat dengan cepat dan akurat menghasilkan informasi tentang karir, keberlanjutan proyek perubahan, dan peningkatan kinerja individu para alumni. Sedangkan hasil analisis data menunjukkan bahwa mayoritas responden evaluasi menyatakan mereka mengalami peningkatan kinerja pascapelatihan yang ditunjukkan dengan keberlanjutan proyek perubahan / inovasi di organisasinya.
Kata Kunci: Pelatihan Kepemimpinan, Evaluasi Dampak Pelatihan, Sistem Informasi
Antibacterial, cytotoxic and trypanocidal activities of marine-derived fungi isolated from Philippine macroalgae and seagrasses
Authors: Notarte Kin Israel , Yaguchi Takashi , Suganuma Keisuke , dela Cruz Thomas Edison 
Published: August 2018

AbstractThe occurrence and bioactivities of marine-derived fungi are evaluated in this paper. A total of 16 morphospecies of marine-derived fungi (MDF) were isolated from four host macroalgae and two seagrasses and identified as belonging to the generaAspergillus,Fusarium,Paecilomyces,Penicillium,Sclerotinia,ThamnidiumandTrichoderma, including fivemycelia sterilia.Among these host organisms, the rhodophyteLaurencia intermediaharboured the highest number of isolated MDF. Selected MDF were then assayed and showed to inhibitPseudomonas aeruginosa(8-19 mm zone of inhibition) andStaphylococcus aureus(6-19 mm zone of inhibition), and were cytotoxic against the brine shrimpArtemia salinanauplii (LD50: 201.56-948.37 μg mL−1). The screening led to the selection of five of the most bioactive morphospecies, all belonging to the genusAspergillus. These marine aspergilli were subjected toβ-tubulingene sequence analysis for species identification, and to mass production in different culture media with or without marine salts, and screening of the crude culture extracts for their cytotoxic and trypanocidal activities.Aspergillus tubingensiscultivated in potato dextrose broth with marine salt proved to be the most cytotoxic against P388 (IC50: 1028 ng mL−1) and HeLa (IC50: 1301 ng mL−1) cancer cells. On the other hand,A. fumigatuscultivated in malt extract broth without marine salt was shown to be the most potent againstTrypanosoma congolense(IC50: 298.18 ng mL−1). Our study therefore showed that salinity may influence the bioactivities of some species of MDF.
Genetic variability and distance between Lactuca serriola L. populations from Sweden and Slovenia assessed by SSR and AFLP markers
Authors: Jemelková Michaela , Kitner Miloslav , Křístková Eva , Doležalová Ivana , Lebeda Aleš 
Published: August 2018

AbstractThe study involved 121 samples of the common weed,Lactuca serriolaL. (prickly lettuce), representing 53 populations from Sweden and Slovenia. The seed materials, originating from different habitats, were regenerated and taxonomically validated at the Department of Botany, Palacký University in Olomouc, Czech Republic. The morphological characterizations of the collected plant materials classified all 121 samples asL. serriolaf.serriola; one sample was heterogeneous, and also present wasL. serriolaf.integrifolia. Differences in the amount and distribution of the genetic variations between the two regions were analyzed using 257 amplified fragment length polymorphism (AFLP) and 7 microsatellite (SSRs) markers. Bayesian clustering and Neighbor-Network were used for visualization of the differences among the samples by country. Under the Bayesian approach, the best partitioning (according to the most frequent signals) was resolved into three groups. While the absence of an admixture or low admixture was detected in the Slovenian samples, and the majority of the Swedish samples, a significant admixture was detected in the profiles of five Swedish samples collected near Malmö, which bore unique morphological features of their rosette leaves. The Neighbor-Network analysis divided the samples into 6 groups, each consisting of samples coming from a particular country. Reflection of morphology and eco-geographical conditions in genetic variation are also discussed.
New Water Act in Poland – Changes and Dilemmas
Authors: Pierzgalski Edward 
Published: August 2018

Abstract
The article presents the reasons and goals of the new Water Act development, which was supposed to replace amended many times the 2001 Water Act. A new Water Act has been approved 1 July 2017. The main aim of new Water Act is an achievements the objectives of the EU Water Framework Directive and other EU directives related to water management. The most important change of new Water Act is the establishment of a new water management organization in Poland, for which since January 1, 2018 is responsible the State Water Enterprise Polish Waters. The second new fundamental change is the introduction of nine water management financial instruments. Water services fees are one of them. The mechanism for determining the amount of these fees was one of the most debatable problems when adopting this legislative document. The article also presents the voices criticizing the detailed introduced solutions, including changes in investment of water infrastructure and their maintenance in agriculture.
Different bias mechanisms in recall and recognition of conceptual and perceptual information of an event
Authors: García-Bajos Elvira , Migueles Malen , Aizpurua Alaitz 
Published: August 2018

Abstract
The aim of this research was to study the memory and response bias for conceptual and perceptual information in the recall and recognition of an event. The participants watched a movie trailer video and their memory of verbal and visual actions and details was evaluated using specific recall questions or a true/false recognition task. The participants recalled and recognized actions better than details, and visual information better than verbal information. Memory biases affected recall and recognition differently. The participants showed a high tendency to accept false verbal actions consistent with the gist of the event as true in the recognition task, while in the recall task the participants were more likely to answer incorrectly questions involving visual perceptual details. These results reflect the different mechanisms which are involved in the processing and cognitive management of conceptual and perceptual information of an event.
USING OF DYNAMIC AND STATIC LOAD PILING TESTS IN ASTANA, KAZAKHSTAN
Authors: Zhussupbekov A. Z. , Shakhmov Z. A. , Tleulenova G. T. , Akhazhanov S. B. 
Published: August 2018

In this paper the analysis results of precast piles different tests are presented. Extreme soil conditions of Astana (Kazakhstan) involve realizing the work precast piles in various soil ground and interaction soil ground and piles. There were carried out dynamic and static load tests of piles in extreme soil ground conditions in Astana. Based on data results of pile foundations the piles bearing capacity was determined. According to the results of DLT with PDA of driving piles (30.0 cm) the bearing capacity of the piles is 911 kN. The bearing capacity of the driven piles according to the results of SLT amounted to be 878 kN. Soils physic-mechanical properties in extreme conditions of Astana along with graphs of dependence are between settlement and load. The precise analysis of climatic and geological factors of the construction sites is shown. Investigations method for precast concrete piles testing is presented. Dynamic load test methodology in Astana for concrete piles testing is shown. These investigations are important for of Pile-Soil interaction on problematical soil ground.
CONSTRUCTIONAL FEATURES OF HEGUMEN HOUSE IN CHERNIHIV
Authors: Kornienko М. V. , Korzachenko М. М. , Bolotov М. G. , Horb О. М. 
Published: August 2018

Research results of the XVII century construction, Hegumen House in Chernihiv, are presented. It is a historically significant local landmark. Attention was paid to historical data on foundation of the monastery and structure erection. The construction was built to serve as a refectory church of Peter and Paul. The purpose of the building was found to have been changed repeatedly during its existence. Constructional features of the structure remains were analyzed. Practical recommendations on its restoration were developed. Underground unit drawing was made, which is accessible to viewing. Detailed research was conducted. Reinforcements and brick wall construction, dated at a later period, were discovered. The wall construction brick was analyzed. Much attention was paid to durability and stableness of the underground unit.
INFLUENCE OF DISTANCE BETWEEN A RETAINING WALL AND THE EXISTING BUILDING ON STRESS-STRAIN STATE OF THE SYSTEM «RETAINING STRUCTURES – SOIL MASSIF»
Authors: Ruchkivskyi V. V. 
Published: August 2018

The results of work research of engineering protective structures in a densely built–up area with difficult engineering–geological conditions have been presented. The modeling of the geotechnical problem of deep excavation protection using a three-tier retaining wall has been performed. The task of mutual influence of existing building and deep excavation with the change of distance between them is solved. The grafs of displacement’s dependence several tiers of retaining walls from the distance to an existing building have been presented. According to these data, a plot of the dependence of displacements of separate tiers of retaining walls from the distance to an existing building is constructed. The problem is solved by the finite element method using a nonlinear model of a solid soil environment. The character of the formation of zones of potential slip surface slope is revealed. The dependence of bending moments of the retaining walls from the distance to the existing building is shown. A safe location of an existing building to a deep excavation has been substinated.
Pengaruh Aplikasi Pupuk Hayati, Vermikompos Dan Pupuk Anorganik Terhadap Kandungan N, Populasi Azotobacter sp. Dan Hasil Kedelai Edamame (Glycine max (L.) Merill) Pada Inceptisols Jatinangor.
Authors: Setiawati Mieke Rochimi , Sofyan Emma Trinurani , Nurbaity Anne , Suryatmana Pujawati , Marihot Gordon Pius 
Published: August 2018

In Indonesia, Inceptisols is the largest soil order on which intensive agriculture is done. The fertility of this soil order is low, so that it is necessary to improve the soil fertility by using biofertilizers and organic matter. The objectives of this experiment were to determine the effect of a biofertilizer that contains microbe Azotobacter sp., Vermicompost and N, P, K Fertilizer on N content, the population of Azotobacter sp., and the yield of the Edamame soybeans at Inceptisols Jatinangor. A Field experiment was conducted by using Randomized Blocked Design consisted of 10 treatments and three replication. The combinations of these treatments consisted of: control (no treatment), the dose recommendation Urea 100 kg ha-1 + SP36 150 kg ha-1 + KCl 125 kg ha-1, 5 ton ha-1 vermicompost + ½ recommendation ha-1 N, P, K, 5 ton ha-1 vermicompost + 1 recommendation ha-1 N, P, K, 5 ton ha-1 vermicompost + 1½ recommendation ha-1 N, P, K, 10 ton ha-1 vermicompost + ½ recommendation ha-1 N, P, K, 10 ton ha-1 vermicompost + 1 recommendation ha-1 N, P, K, 10 ton ha-1 vermicompost + 1½ recommendation ha-1 N, P, K, 5 ton ha-1 vermicompost + ½ recommendation ha-1 N, P, K + liquid biofertilizers 5 L ha-1, 10 ton ha-1 Vermicompost + ½ recommendation ha-1 N, P, K + liquid biofertilizers 5 L ha-1. The experimental results showed that the combined treatment of liquid biofertilizer, Vermicompost and N, P, K fertilizer enhanced the population of Azotobacter sp. and weight of soybean but did not significantly influence N uptake.