bluuebunny/crossref_metadata_2025_split huggingface dataset:
State of Play: Eight Decades of Surgery for Esophageal Atresia
Authors: Zimmer Julia , Eaton Simon , Murchison Louise , De Coppi Paolo , Ure Benno , Dingemann Carmen 
Published: August 2018

Aim Surgical expertise and advances in technical equipment and perioperative management have led to enormous progress in survival and morbidity of patients with esophageal atresia (EA) in the last decades. We aimed to analyze the available literature on surgical outcome of EA for the past 80 years.
Materials and Methods A PubMed literature search was conducted for the years 1944 to 2017 using the keywords “esophageal/oesophageal atresia,” “outcome,” “experience,” “management,” and “follow-up/follow up.” Reports on long-gap EA only, non-English articles, case reports, and reviews without original patient data were excluded. We focused on mortality and rates of recurrent fistula, leakage, and stricture.
Results Literature search identified 747 articles, 118 manuscripts met the inclusion criteria. The first open end-to-end anastomosis and fistula ligation was reported in 1941. Thoracoscopic fistula ligation and primary anastomosis was performed first in 2000. Reported mortality rate decreased from 100% before 1941 to 54% in 1950 to 1959, 28% in 1970 to 1979, 16% in 1990 to 1999, and 9% nowadays. Rates of recurrent fistula varied over time between 4 and 9%. Leakage rate remained stable between 11 and 16%. However, stricture rate increased from 25 to 38%.
Conclusion Including a full range of articles reflecting the heterogeneity of EA, mortality rate significantly decreased during the course of 80 years. Along with the decrease in mortality, there is a shift to the importance of major postoperative complications and long-term morbidity regardless of surgical technique.
Unilateral Autologous Breast Reconstruction with Bi-pedicled, Conjoined Deep Inferior Epigastric Perforator Flaps
Authors: Seth Akhil , Koolen Pieter , Sultan Steven , Lee Bernard , Erhard Heather , Greenspun David 
Published: August 2018

Background The abdomen remains the most popular and reliable donor site for autologous breast reconstruction. Some patients, however, lack sufficient tissue to recreate an aesthetic breast mound using a single-pedicle, deep inferior epigastric perforator (DIEP) flap, particularly when matching a contralateral native breast. The amount of abdominal skin and/or soft tissue reliably supplied by one vascular pedicle is frequently insufficient to adequately restore the breast skin envelope and “footprint.” This study summarizes our experience with using bipedicled DIEP flaps to improve the aesthetic results of unilateral breast reconstruction in such patients.
Methods Consecutive patients undergoing unilateral breast reconstruction with bi-pedicled, conjoined DIEP flaps over a 4-year period were retrospectively reviewed. Primary and secondary flap microvascular anastomoses were performed to the antegrade internal mammary (IM) vessels and to either the retrograde IM vessels or a primary DIEP pedicle side branch, respectively. Clinical characteristics and outcomes were recorded.
Results Sixty-three patients underwent immediate (n = 29) or delayed (n = 34) reconstruction, with age and body mass index of 54.1 ± 8.4 years and 26.6 ± 4.7, respectively. Mean follow-up was 14.1 months. Twenty-eight (44.4%) patients received prereconstruction radiation therapy. All patients had preoperative abdominal imaging, including 57 (90.5%) using magnetic resonance angiography. There were no flap losses with three operative interventions for flap salvage.
Conclusion Unilateral breast reconstruction with bipedicled, conjoined DIEP flaps is safe and reliable. These procedures can be performed with a complication profile similar to single-pedicle DIEP flaps. The additional skin and soft tissue available with bi-pedicled flaps allows for greater flexibility in matching the shape and projection of a woman's contralateral breast, and in some cases is necessary to achieve an aesthetically acceptable reconstruction. With growing expectations among breast reconstruction patients, conjoined bi-pedicled flaps represent a tool for meeting their reconstructive needs and exceeding the status quo for aesthetic outcomes.
Bilateral Paravertebral Block versus Thoracic Epidural Analgesia for Pain Control Post-Cardiac Surgery: A Randomized Controlled Trial
Authors: El Shora Hatem A. , El Beleehy Ahmed A. , Abdelwahab Amr A. , Ali Gaser A. , Omran Tarek E. , Hassan Essam A. , Arafat Amr A. 
Published: August 2018

Background Adequate pain control after cardiac surgery is essential. Paravertebral block is a simple technique and avoids the potential complications of epidural catheters. The objective of this study is to compare the effect of ultrasound-guided bilateral thoracic paravertebral block with thoracic epidural block on pain control after cardiac surgery.
Materials and Methods Between March 2016 and 2017, 145 patients who had cardiac surgery through median sternotomy were randomized by stratified blocked randomization into two groups. Group I (n = 70 patients) had bilateral ultrasound-guided thoracic paravertebral block and Group II (n = 75 patients) had thoracic epidural analgesia. The primary end point was the postoperative visual analogue scale (VAS). The duration of mechanical ventilation, intensive care unit (ICU), and hospital stay were the secondary end points. The study design is a randomized parallel superiority clinical trial.
Results Both groups had similar preoperative and operative characteristics. No significant difference in VAS measured immediately after endotracheal extubation then after 12, 24, and 48 hours between groups (p = 0.45). Pain score significantly declined with the repeated measures (p < 0.001) and the decline was not related to the treatment group. Postoperative pain was significantly related to diabetes mellitus (p = 0.039). Six patients in group I (8.5%) required an additional dose of morphine versus three patients (4%) in group II (p = 0.30). Patients in group I had significantly shorter ICU stay (p = 0.005) and lower incidence of urinary retention (p = 0.04) and vomiting (p = 0.018). No difference was found in operative complications between groups.
Conclusion This randomized parallel controlled trial demonstrates that ultrasound-guided paravertebral block is safe and effective method for relieving post-cardiac surgery sternotomy pain compared with thoracic epidural analgesia but not superior to it.
Minimally Invasive Redo-Aortic Valve Replacement: Reduced Operative Times as Compared to Full Sternotomy
Authors: Oezpeker Cenk , Barbieri Fabian , Zujs Vitalijs , Grimm Michael , Lio Antonio , Glauber Mattia , Bonaros Nikolaos 
Published: August 2018

Abstract
Objectives Increasing experience with minimally invasive cardiac (MIC) aortic valve (AV) replacement makes AV reoperations (rAVR) an appealing alternative to conventional redo surgery. The aim of the study was to compare the perioperative outcome after isolated MIC versus full-sternotomy (FS) rAVR.
Methods We retrospectively analyzed data of 116 patients from three centers who underwent rAVR by using a FS (n = 70, 60.3%) or a partial upper sternotomy approach (n = 46, 39.7%). Both groups were compared in terms of 30-day mortality by using binary-logistic regression models. Further the EuroSCORE II was used to adjust for preoperative conditions in a multivariable model. Perioperative times and complications were compared between the two groups.
Results There was no statistically significant difference in perioperative mortality between FS (n = 5, 7.1%) and MIC (n = 1, 2.2%) rAVR in the original population (odds ratio [OR] 3.462, 95% confidence interval [CI] 0.391–30,635, p = 0.264) and after adjusting for EuroSCORE II (OR 2.759, 95% CI 0.298–25.567, p = 0.372). Cardiopulmonary bypass- (115.5 minutes vs. 137.5 minutes, p = 0.070) and cross-clamp times (69.0 minutes vs. 81.0 minutes, p = 0.028) were reduced in the MIC group. There was a lower prevalence of postoperative renal failure requiring renal replacement therapy (RRT) in the MIC group 0 and 8.6% (p = 0.041), respectively. No differences were detected between the groups regarding postoperative complications.
Conclusion MIC rAVR is associated with reduced cardiopulmonary and cross-clamp times as well as the need for RRT as compared with FS. MIC-rAVR seems to be a viable option in surgical candidates for AV reoperations.
Tromboflebitis superficial del pene: primer reporte de caso en el Hospital Universitario Nacional de Colombia y recomendaciones actuales de manejo
Authors: Castañeda David , Velásquez Jonatan , Maya Daniel , Pardo Julián , Capera César , Guzmán Carlos , Donoso Wilfredo 
Published: August 2018

ResumenLa enfermedad de Mondor es una condición caracterizada por la presencia de tromboflebitis en varios segmentos corporales, fue descrita inicialmente por Henri Mondor en 1939 con descripciones de casos que afectaban la circulación venosa de la reja costal y las glándulas mamarias. Se alude a Braun-Falco en 1955 la primera mención de la trombosis superficial del pene, sin embargo, fue hasta 1958 cuando Helm y Hodge describieron el primer caso con compromiso urogenital masculine. Actualmente se cuenta con información limitada sobre la tromboflebitis superficial del pene (enfermedad peniana de Mondor), por lo tanto, el presente artículo describe el primer caso de tromboflebitis de la vena superficial del pene registrado en el Hospital Universitario Nacional de Colombia y expone una propuesta de abordaje terapéutico actual, basada en una revisión reciente de la literatura.
Electrical Stimulation to the Infraspinatus on Hypertrophy and Strength of the Shoulder
Authors: Yanase Ko , Hasegawa Satoshi , Nakamura Masatoshi , Yamauchi Taishi , Nishishita Satoru , Araki Kojiro , Umehara Jun , Fujita Kosuke , Sato Ikuya , Ibuki Satoko , Ichihashi Noriaki 
Published: August 2018

AbstractThe purpose of this study was to determine the effects of six weeks of electrical muscle stimulation (EMS) on the strength and muscle mass of the infraspinatus muscle. Twenty non-athletes (age: 24±3.4 years, height: 171.5±5.6 cm, mass: 65.2±8.1 kg) were randomly classified into two groups, an electrical muscle stimulation group (EMS group) and a control group (CON group). The EMS group completed a total of 18 20– min EMS sessions, three times per week over a period of six weeks, while the CON group received no intervention. The muscle thicknesses of both the infraspinatus and the deltoid muscles, the cross-sectional area (CSA) of the whole infraspinatus muscle, and the isometric and isokinetic peak torques of shoulder external rotations were measured before and after intervention. It was found that the muscle thickness of the superior infraspinatus (Pre 0.92±0.19 cm2, Post 0.99±0.16 cm2, p=0.02) and the CSA (Pre 10.99±1.32 cm2, Post 11.99±1.02 cm2, p=0.03) significantly increased in the EMS group. This study demonstrated that EMS of the infraspinatus muscle over a period of six weeks resulted in hypertrophy of the infraspinatus muscle.
Exploring the Response of Combined Urban Sewer System to the Implementation of Green Roof
Authors: Gao Yuqin , Wang Dongdong , Schmidt A , Tang Yun 
Published: August 2018

Abstract
In order to find an efficient and reliable method for assessing the impact of green roofs on runoff in urban areas, IUHM-GreenRoof combination model is established via Matlab. Taking CDS-51 catchment located in Dolton, Illinois as a case, and considering different green roof coverage ratios as well as runoff conditions, the influence on the catchment outlet runoff because of the application of green roofs is analysed by running the model in two typical storms. The results show that green roofs have good water storage capacity, which can effectively decrease the catchment runoff in terms of peak discharge and volume. Moreover, the green roof coverage ratio has more influence on runoff than green roof runoff conditions.
Study on the Pin-load Distribution of Composite Joints with Protruding-head Bolts Based on Cumulative Damage
Authors: Liu Xiangdong , Zhang Huimei , Liu Na , Li Linjie 
Published: August 2018

Abstract
This paper presents the investigation of the pin–load distribution law of composite mechanical joints with protruding-head bolts based on the theory of composite cumulative damage. The three-dimensional finite element analysis have been carried out by using the software ANSYS for the composite plates connected with protruding-head bolts. The friction on the contact surfaces of the composite joints, and the nonlinearity of the contact state and the preload on the bolts have been considered. The effect law of cumulative damage on the pin-load distribution of multiple-bolted joints has been achieved. The results manifest that the proportion of the pin-load distribution varies with the external load and is slightly different at diverse stages of loading considering the cumulative damage of the composite materials, that pin load at both ends is greater than in the middle.
Effect of Curing Temperature on Activity Index of Silica Fume
Authors: Dai Jinpeng , Wang Qicai , Xie Chao , Xie Zhigang , Tian Xianfu , Lou Xuyu , Guo Haizhen 
Published: August 2018

Abstract
The compressive strength of the contrast mortars and test mortars at different curing temperatures at different ages were tested. Effect of curing temperature on the strength of the test mortars and the contrast mortars was analyzed. The relative activity index and absolute activity index of the silica fume were studied. The mercury porosimetry method was used to test the pore structure of mortar specimens, and the improving effect of silica fume on the pore structure of mortar specimens under different curing temperatures was analyzed. The results show that with the increase of age, the decrease of curing temperature will cause the strength of mortar specimens to slow down. At the 3d and 7d ages, with the decrease of curing temperature, the absolute activity value of silica fume gradually increases. After 7 days of age, with the decrease of curing temperature, the absolute activity of silica fume gradually decreases. With the increase of curing age, the relative activity of silica fume decreases at first and then increases at 20°C and 10°C. The relative activity value of silica fume under the maintenance of 5°C and -3°C increased first and then decreased gradually. The addition of silica fume in the concrete improved the internal pore structure of the specimen, and the effect of curing temperature on the specimen was consistent.
Decoupling Evolutionary Programming from Gigabit Switches in Neural Networks
Authors: Ling Hangkun 
Published: August 2018

Abstract
Superpages and Lamport clocks, while technical in theory, have not until recently been considered confirmed. In fact, few futurists would disagree with the understanding of voice-over-IP. We confirm that red-black trees can be made omniscient, replicated, and game-theoretic.
Microtexture and the Cell/Biomaterial Interface: A Systematic Review and Meta-Analysis of Capsular Contracture and Prosthetic Breast Implants
Authors: Shauly Orr , Gould Daniel J , Patel Ketan M 
Published: August 2018

Abstract

Background
The use of textured breast implants over smooth implants has been widely shown to have a lower incidence of capsular contracture. However, the impact of micropatterning techniques on the incidence of postoperative patient morbidity has not been comprehensively investigated.

Objectives
The authors sought to examine the incidence of capsular contracture, seroma, and implant rippling among the 3 major micropatterning techniques applied in the manufacturing of textured breast implants.

Methods
Literature searches of PubMed/Medline and Embase between 1995 and 2017 were performed, and 19 studies were selected for analysis. Data from each study were extracted into a form including mean age, study design, population size, mean follow-up, number of capsular contracture cases, number of seroma cases, and number of rippling cases. Meta-analysis was performed separately for studies that included capsular contracture rates for foam textured implants, imprinted textured implants, and salt-loss textured implants.

Results
The pooled rate of capsular contracture rates in primary augmentation patients was 3.80% (95% CI, 2.19-5.40) for imprinted textured implants, 4.90% (95% CI, 3.16-6.64) for foam textured implants, 5.27% (95% CI, 3.22-7.31) for salt-loss textured implants, and 15.56% (95% CI, 13.31-18.16) for smooth implants. The results of each meta-analysis were summarized on a forest plot depicting the distribution of capsular contracture rates from each study.

Conclusions
Micropatterning of prosthetic implants could drastically reduce postoperative patient morbidity given the advent of recent technologies that allow for more detailed texturing of implant surfaces.

Level of Evidence: 4
StructureProfiler: an all-in-one tool for 3D protein structure profiling
Authors: Meyder Agnes , Kampen Stefanie , Sieg Jochen , Fährrolfes Rainer , Friedrich Nils-Ole , Flachsenberg Florian , Rarey Matthias 
Published: August 2018

Abstract

Motivation
Three-dimensional protein structures are important starting points for elucidating protein function and applications like drug design. Computational methods in this area rely on high quality validation datasets which are usually manually assembled. Due to the increase in published structures as well as the increasing demand for specially tailored validation datasets, automatic procedures should be adopted.

Results
StructureProfiler is a new tool for automatic, objective and customizable profiling of X-ray protein structures based on the most frequently applied selection criteria currently in use to assemble benchmark datasets. As examples, four dataset configurations (Astex, Iridium, Platinum, combined), all results of the combined tests and the list of all PDB Ids passing the combined criteria set are attached in the Supplementary Material.

Availability and implementation
StructureProfiler is available as part of the ProteinsPlus web service http://proteins.plus and as standalone tool in the NAOMI ChemBio Suite. Dataset updates together with the tool can be found on http://www.zbh.uni-hamburg.de/structureprofiler.

Supplementary information
Supplementary data are available at Bioinformatics online.
The long non-coding RNA landscape of periodontal ligament stem cells subjected to compressive force
Authors: Huang Yiping , Zhang Yingying , Li Xiaobei , Liu Hao , Yang Qiaolin , Jia Lingfei , Zheng Yunfei , Li Weiran 
Published: August 2018

Summary

Objective
The role of long non-coding ribonucleic acids (lncRNAs) during orthodontic tooth movement remains unclear. We explored the lncRNA landscape of periodontal ligament stem cells (PDLSCs) subjected to compressive force.

Materials and methods
PDLSCs were subjected to static compressive stress (2 g/cm2) for 12 hours. Total RNA was then extracted and sequenced to measure changes in lncRNA and messenger RNA (mRNA) expression levels. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate the expression levels of certain lncRNAs. Differential expression analysis as well as Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were also performed.

Results
In total, 90 lncRNAs and 519 mRNAs were differentially expressed in PDLSCs under compressive stress. Of the lncRNAs, 72 were upregulated and 18 downregulated. The levels of eight lncRNAs of interest (FER1L4, HIF1A-AS2, MIAT, NEAT1, ADAMTS9-AS2, LUCAT1, MIR31HG, and DHFRP1) were measured via qRT-PCR, and the results were found to be consistent with those of RNA sequencing. GO and KEGG pathway analyses showed that a wide range of biological functions were expressed during compressive loading; most differentially expressed genes were involved in extracellular matrix organization, collagen fibril organization, and the cellular response to hypoxia.

Conclusions
The lncRNA expression profile was significantly altered in PDLSCs subjected to compressive stress. These findings expand our understanding of molecular regulation in the mechanoresponse of PDLSCs.
Opportunities for intervention: stroke treatments, disability and mortality in urban Tanzania
Authors: Regenhardt Robert W , Biseko Maijo R , Shayo Agness F , Mmbando Theoflo N , Grundy Sara J , Xu Ai , Saadi Altaf , Wibecan Leah , Kharal G Abbas , Parker Robert , Klein Joshua P , Mateen Farrah J , Okeng’o Kigocha 
Published: August 2018

AbstractObjectiveGiven the high post-stroke mortality and disability and paucity of data on the quality of stroke care in Sub-Saharan Africa, we sought to characterize the implementation of stroke-focused treatments and 90-day outcomes of neuroimaging-confirmed stroke patients at the largest referral hospital in Tanzania.DesignProspective cohort study.SettingMuhimbili National Hospital (MNH) in Dar es Salaam, July 2016–March 2017.ParticipantsAdults with new-onset stroke (<14 days), confirmed by head CT, admitted to MNH.Main outcomes measuresModified Rankin scale (mRS) and vital status.ResultsOf 149 subjects (mean age 57; 48% female; median NIH stroke scale (NIHSS) 19; 46% ischemic stroke; 54% hemorrhagic), implementation of treatments included: dysphagia screening (80%), deep venous thrombosis prophylaxis (0%), aspirin (83%), antihypertensives (89%) and statins (95%). There was limited ability to detect atrial fibrillation and carotid artery disease and no acute thrombolysis or thrombectomy. Of ischemic subjects, 19% died and 56% had severe disability (mRS 4–5) at discharge; 49% died by 90 days. Of hemorrhagic subjects, 33% died and 49% had severe disability at discharge; 50% died by 90 days. In a multivariable model, higher NIHSS score but not dysphagia, unconsciousness, or patient age was predictive of death by 90 days.ConclusionsThe 90-day mortality of stroke presenting at MNH is 50%, much higher than in higher income settings. Although severe stroke presentations are a major factor, efforts to improve the quality of care and prevent complications of stroke are urgently needed. Acute stroke interventions with low number needed to treat represent challenging long-term goals.
Frequent Diagnostic Under-Grading in Isocitrate Dehydrogenase Wild-Type Gliomas due to Small Pathological Tissue Samples
Authors: Gutt-Will Marielena , Murek Michael , Schwarz Christa , Hewer Ekkehard , Vulcu Sonja , Beck Jürgen , Raabe Andreas , Schucht Philippe 
Published: August 2018

Abstract

BACKGROUND
In contrast to isocitrate dehydrogenase (IDH) mutation analysis, which is homogenous within a given tumor, diagnostic errors in histological analysis following the 2016 World Health Organization (WHO) classification could be due to small samples because of histological heterogeneity.

OBJECTIVE
To assess whether the sample size sent to histopathology influences the tumor grading in IDH wild-type gliomas.

METHODS
Histologically diagnosed WHO grade, sample volume, and preoperative tumor volume data of 111 patients aged who received resection of IDHwt gliomas between January 2007 and December 2015 at our hospital were evaluated. The differences between absolute and relative pathological sample sizes stratified by WHO grade were conducted using One-Way-Permutation-Test.

RESULTS
With a mean sample size of 10.9 cc, 83.8% of patients were histologically diagnosed as WHO grade IV, while 16.2% of patients with a mean sample size of 2.62 cc were diagnosed as WHO grade II/III. One-Way-Permutation-Test showed a significant difference between absolute tissue samples stratified by WHO grade (P = .0374). The distribution of preoperative tumor volumes with WHO grade IV vs WHO grade II/III showed no significant difference (P = .8587). Of all tumors with a sample size >10 cc 100% were pathologically diagnosed as WHO grade IV and those with sample size >5 cc 93.5% were diagnosed as WHO grade IV.

CONCLUSION
Small sample sizes are associated with a higher risk of under-estimating malignancy in histological grading in IDHwt gliomas. This study suggests a standard minimum sample size (>5cc) in every resection. Modalities of adjuvant treatment for IDHwt, WHO grade II/III gliomas need to reflect a prognosis that is only marginally better than of a glioblastoma.