bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomised controlled trial using a theory-based m-health intervention to improve physical activity and sleep health in adults: the Synergy Study protocol
Authors: Murawski Beatrice , Plotnikoff Ronald C , Rayward Anna T , Vandelanotte Corneel , Brown Wendy J , Duncan Mitch J 
Published: February 2018

IntroductionThere is a need to reduce physical inactivity and poor sleep health in the adult population to decrease chronic disease rates and the associated burden. Given the high prevalence of these risk behaviours, effective interventions with potential for wide reach are warranted.Methods and analysisThe aim of this two-arm RCT will be to test the effect of a three month personalised mobile app intervention on two main outcomes: minutes of moderate-to-vigorous-intensity physical activity and overall sleep quality. In addition, between-group changes in health-related quality of life and mental health status will be assessed as secondary outcomes. The pre-specified mediators and moderators include social cognitive factors, the neighbourhood environment, health (BMI, depression, anxiety, stress), sociodemographic factors (age, gender, education) and app usage. Assessments will be conducted after three months (primary endpoint) and six months (follow-up). The intervention will provide access to a specifically developed mobile app, through which participants can set goals for active minutes, daily step counts, resistance training, sleep times and sleep hygiene practice. The app also allows participants to log their behaviours daily and view progress bars as well as instant feedback in relation to goals. The personalised support system will consist of weekly summary reports, educational and instructional materials, prompts on disengagement and weekly facts.Ethics and disseminationThe Human Research Ethics Committee of The University of Newcastle, Australia granted full approval: H-2016–0181. This study will assess the efficacy of a combined behaviour intervention, mechanisms of behaviour change and gather high-quality process data, all of which will help refine future trials. Dissemination of findings will include publication in a peer-reviewed journal and presentation at national or international conferences. Participants will receive a plain English summary report of results.Trial registration numberACTRN12617000376347; Pre-results.
Retrospective analysis of the national impact of industrial action by English junior doctors in 2016
Authors: Furnivall Daniel , Bottle Alex , Aylin Paul 
Published: February 2018

ObjectivesTo examine the impacts of the four episodes of industrial action by English junior doctors in early 2016.DesignDescriptive retrospective study of admitted patient care, accident and emergency (A&E) and outpatient activity in English hospitals.SettingAll hospitals across England.ParticipantsAll patients who attended A&E or outpatient appointments or those who were admitted to hospital during the 3-week period surrounding each of the four strikes (12 January, 10 February, 9–10 March and 26–27 April, excluding weekends).Main outcome measuresRaw numbers and percentage changes of outpatient appointments and cancellations, A&E visits, admitted patients and all inhospital mortality on strike days compared with patient activity on the same weekday in the weeks before and after the strikes.ResultsThere were 3.4 million admissions, 27 million outpatient appointments and 3.4 million A&E attendances over the four 3-week periods analysed. Across the four strikes, there were 31 651 fewer admissions (−9.1%), 23 895 fewer A&E attendances (−6.8%) and 173 462 fewer outpatient appointments (−6.0%) than expected. Additionally, 101 109 more outpatient appointments were cancelled by hospitals than expected (+52%). The 26–27 April strike, where emergency services were also affected, showed the largest impacts on regular service. Mortality did not measurably increase on strike days. Regional analysis showed that services in the Yorkshire and the Humber region were disproportionately more affected by the industrial action.ConclusionsIndustrial action by junior doctors during early 2016 caused a significant impact on the provision of healthcare provided by English hospitals. We also observed regional variations in how these strikes affected providers.
Research of the impact of coupling between unit cells on performance of linear-to-circular polarization conversion metamaterial with half transmission and half reflection
Authors: Guo Mengchao , Zhou Kan , Wang Xiaokun , Zhuang Haiyan , Tang Dongming , Zhang Baoshan , Yang Yi 
Published: February 2018

In this paper, the impact of coupling between unit cells on the performance of linear-to-circular polarization conversion metamaterial with half transmission and half reflection is analyzed by changing the distance between the unit cells. An equivalent electrical circuit model is then built to explain it based on the analysis. The simulated results show that, when the distance between the unit cells is 23 mm, this metamaterial converts half of the incident linearly-polarized wave into reflected left-hand circularly-polarized wave and converts the other half of it into transmitted left-hand circularly-polarized wave at 4.4 GHz; when the distance is 28 mm, this metamaterial reflects all of the incident linearly-polarized wave at 4.4 GHz; and when the distance is 32 mm, this metamaterial converts half of the incident linearly-polarized wave into reflected right-hand circularly-polarized wave and converts the other half of it into transmitted right-hand circularly-polarized wave at 4.4 GHz. The tunability is realized successfully. The analysis shows that the changes of coupling between unit cells lead to the changes of performance of this metamaterial. The coupling between the unit cells is then considered when building the equivalent electrical circuit model. The built equivalent electrical circuit model can be used to perfectly explain the simulated results, which confirms the validity of it. It can also give help to the design of tunable polarization conversion metamaterials.
Atrial arrhythmias and autonomic dysfunction in rats exposed to chronic intermittent hypoxia
Authors: Bober Sara L. , Ciriello John , Jones Douglas L. 
Published: February 2018

Obstructive sleep apnea, which involves chronic intermittent hypoxia (CIH), is a major risk factor for developing atrial fibrillation (AF). Whether or not CIH alone alters cardiac mechanisms to support AF is unknown. This study investigated the effects of CIH on atrial electrophysiology and arrhythmia vulnerability and evaluated the role of autonomics in CIH promotion of AF. Adult male Sprague-Dawley rats were exposed to 8 h/day of CIH or normoxia for 7 days. After exposure, rats were anesthetized for intracardiac electrophysiological experiments. Atrial effective refractory periods (AERPs) and AF inducibility were determined using programmed electrical stimulation and burst pacing in the absence and presence of autonomic receptor agonists and antagonists. Western blot analysis measured atrial protein expression of muscarinic M2, M3, and β1-adrenergic receptors. Compared with normoxia-exposed control rats, CIH-exposed rats had enhanced AF vulnerability using both programmed electrical stimulation and burst pacing, accompanied by greater AERP responses to carbachol and propranolol, lesser responses to isoproterenol, and higher atrial M2 receptor protein levels. Enhanced atrial vulnerability was accentuated by carbachol and abolished by atropine, indicating that the AF-promoting effects of CIH depended principally on parasympathetic activation. Enhancement of atrial vulnerability and AERP shortening with cholinergic agonists in CIH-exposed rats is consistent with sensitivity to parasympathetic activation. Higher responses to adrenergic receptor blockade in CIH-exposed rats is consistent with sympathetic potentiation. These findings implicate CIH as an important mediator of enhanced AF susceptibility in obstructive sleep apnea and provide novel insights into the underlying mechanisms. NEW & NOTEWORTHY Our study demonstrates, for the first time, that chronic intermittent hypoxia alone enhances vulnerability to atrial arrhythmia induction, which depends principally on parasympathetic activation. Enhanced atrial vulnerability was accompanied by heightened electrophysiological responses of the atrial myocardium to carbachol and isoproterenol, dampened responses to propranolol, and increased atrial M2 receptor protein levels.
Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition
Authors: Lang Jessica D. , Hendricks William P.D. , Orlando Krystal A. , Yin Hongwei , Kiefer Jeffrey , Ramos Pilar , Sharma Ritin , Pirrotte Patrick , Raupach Elizabeth A. , Sereduk Chris , Tang Nanyun , Liang Winnie S. , Washington Megan , Facista Salvatore J. , Zismann Victoria L. , Cousins Emily M. , Major Michael B. , Wang Yemin , Karnezis Anthony N. , Sekulic Aleksandar , Hass Ralf , Vanderhyden Barbara C. , Nair Praveen , Weissman Bernard E. , Huntsman David G. , Trent Jeffrey M. 
Published: February 2018

Abstract
Purpose: Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare, aggressive ovarian cancer in young women that is universally driven by loss of the SWI/SNF ATPase subunits SMARCA4 and SMARCA2. A great need exists for effective targeted therapies for SCCOHT.
Experimental Design: To identify underlying therapeutic vulnerabilities in SCCOHT, we conducted high-throughput siRNA and drug screens. Complementary proteomics approaches profiled kinases inhibited by ponatinib. Ponatinib was tested for efficacy in two patient-derived xenograft (PDX) models and one cell-line xenograft model of SCCOHT.
Results: The receptor tyrosine kinase (RTK) family was enriched in siRNA screen hits, with FGFRs and PDGFRs being overlapping hits between drug and siRNA screens. Of multiple potent drug classes in SCCOHT cell lines, RTK inhibitors were only one of two classes with selectivity in SCCOHT relative to three SWI/SNF wild-type ovarian cancer cell lines. We further identified ponatinib as the most effective clinically approved RTK inhibitor. Reexpression of SMARCA4 was shown to confer a 1.7-fold increase in resistance to ponatinib. Subsequent proteomic assessment of ponatinib target modulation in SCCOHT cell models confirmed inhibition of nine known ponatinib target kinases alongside 77 noncanonical ponatinib targets in SCCOHT. Finally, ponatinib delayed tumor doubling time 4-fold in SCCOHT-1 xenografts while reducing final tumor volumes in SCCOHT PDX models by 58.6% and 42.5%.
Conclusions: Ponatinib is an effective agent for SMARCA4-mutant SCCOHT in both in vitro and in vivo preclinical models through its inhibition of multiple kinases. Clinical investigation of this FDA-approved oncology drug in SCCOHT is warranted. Clin Cancer Res; 24(8); 1932–43. ©2018 AACR.
Analysis of Wire-Guided Hemostasis Introducer for Percutaneous Therapy of Bile Duct Stones
Authors: Hollenbach Marcus , Feisthammel Jürgen , Mössner Joachim , Hoffmeister Albrecht 
Published: February 2018

Background: Bile duct stones (BDS) are usually removed via endoscopic retrograde cholangiopancreatography (ERCP) or, if ERCP remains unsuccessful, percutaneous transhepatic cholangiodrainage (PTCD). However, PTCD provides limited access to large BDSs. We analyzed a modified approach of PTCD for percutaneous therapy of BDS. Methods: We used a modified approach of PTCD with a 13-french (Fr) hemostasis introducer for transhepatic access to BDS. Short-wired balloon or basket catheter were applied for safe removal of BDS. Patient characteristics, effectiveness, and complications were analyzed. Results: We identified 11 patients who underwent PTCD with hemostasis introducer. BDSs were either pushed forward to the duodenum (36%) or both partly pushed and extracted via hemostasis introducer (64%). In some cases, mechanical lithotripsy was necessary (45%). Complete removal of BDS was initially achieved in 36% of patients, 45% received additional PTCD, and in 19% stent implantation was performed. Finally, all BDSs could be removed. Laboratory analysis revealed significant reduction of alkaline phosphatase (p = 0.03) and C reactive protein (p = 0.03). Complications occurred only in 1 patient with post-interventional cholangitis. Conclusion: Our study showed feasibility and safety of a modified PTCD with hemostasis introducer. In addition, protection of liver tissue from sharp-edged catheters and stones was achieved. Therefore, our modification revealed an innovational approach for transhepatic removal of BDS.
Clinicopathological Features and Magnifying Chromoendoscopic Findings of Non-Ampullary Duodenal Epithelial Tumors
Authors: Toya Yosuke , Endo Masaki , Akasaka Risaburo , Urushikubo Jun , Gonai Takahiro , Asakura Kensuke , Yanai Shunichi , Kawasaki Keisuke , Eizuka Makoto , Uesugi Noriyuki , Nakamura Shotaro , Sugai Tamotsu , Matsumoto Takayuki 
Published: February 2018

Background and Aims: We aimed to investigate an association between clinicopathological features, including immunohistochemical mucin phenotypes, and magnifying chromoendoscopic findings with crystal violet staining (ME-CV) in non-ampullary duodenal epithelial tumors (NADETs). Methods: A total of 55 patients with NADET were divided into 3 groups by mucin phenotype: intestinal, gastrointestinal, or gastric. ME-CV findings were classified into 4 patterns: convoluted, leaf-like, reticular/sulciolar, and pinecone. The clinicopathological features and ME-CV findings were compared among the mucin phenotypes. Results: Tumors of the gastric type were located in the duodenal bulb (p < 0.001), and contained pyloric gland adenoma (p < 0.001) more frequently than the other types. White-light endoscopy indicated that milk-white mucosa was less frequent in tumors of the gastric type than in those of the gastrointestinal type (p = 0.006) and the intestinal type (p < 0.001). ME-CV findings were significantly different between the gastric type and the other type (p = 0.028). Totally, 5 of 8 tumors of the gastric type manifested a pinecone pattern, 4 of which were compatible with pyloric gland adenoma. Conclusions: The endoscopic findings of NADETs differ according to mucin phenotype. A pinecone pattern under ME-CV may be characteristic of NADETs of the gastric type, especially pyloric gland adenoma.
Οὐδὲν λέγειν / nihil dicere
Authors: Chiarini Sara 
Published: February 2018

AbstractThe ancient theoretical debate on language and its purposes has long concerned scholarship, but only in recent years a growing attention has been directed to ancient concepts and instances of nonsense in both communication and artistic-literary expression, as the recent monograph by Stephen Kidd attests. This paper engages in an analysis of the phrase οὐδὲν λέγειν/nihil dicere, used to express the nonsense of a statement. An overview of the occurrences of οὐδὲν λέγειν is followed by a survey of what can be considered the ‘reception’ or calque of the Greek idiom in Latin, namely nihil dicere. The concentration of the occurrences, both in Greek and Latin, in the same two genres, i.e. comedy and philosophical dialogue, suggests that the phrase was borrowed from the colloquial vocabulary of the spoken language. The authority of Aristophanes and Plato seems to have eased the assimilation of the locution by authors such as Plautus, Terence and Cicero. The rarity of the phrase outside these authors and their genres supports the thought that, in literature, οὐδὲν λέγειν/nihil dicere were typical of the lexical repertoires of dramatic ἀγών and dialectics.
‘Something happened, something bad’: Blackouts, uncertainties and event construal in The Girl on the Train
Authors: Giovanelli Marcello 
Published: February 2018

This article examines the representation of mind style in Paula Hawkins’ (2015) best-selling novel The Girl on the Train. It examines how Hawkins presents the fictional mind of Rachel, a character who is affected by anterograde amnesia as a result of alcoholic blackouts. Rachel’s narrative voice drives the novel, and its retelling of events is characterised by her inability to recall important information related to the night that a young woman disappeared and was murdered. This article specifically draws on the Cognitive Grammar notion of construal to explore the presentation of Rachel’s mind style and its affordances and limitations. In doing so, it builds on developing scholarship that has identified the potential for Cognitive Grammar to provide a richly nuanced account of the representation of a fictional mind. The analysis specifically examines two ways in which event construal is presented: nominal grounding strategies and reference point relationships. For the latter, the article also develops emerging work that has sought to make a connection between Cognitive Grammar and Text World Theory in terms of how mental representations are projected by the text.
Inhibition of spinal MAPKs by scorpion venom peptide BmK AGAP produces a sensory-specific analgesic effect
Authors: Ruan Jia-Ping , Mao Qing-Hong , Lu Wu-Guang , Cai Xue-Ting , Chen Jiao , Li Qing- , Fu Qun- , Yan Huai-Jiang , Cao Jun-Li , Cao Peng 
Published: February 2018

Background Several studies have shown that scorpion venom peptide BmK AGAP has an analgesic activity. Our previous study also demonstrated that intraplantar injection of BmK AGAP ameliorates formalin-induced spontaneous nociceptive behavior. However, the effect of intrathecal injection of BmK AGAP on nociceptive processing is poorly understood. Methods We investigated the effects of intrathecal injection of BmK AGAP on spinal nociceptive processing induced by chronic constrictive injury or formalin. Thermal hyperalgesia and mechanical allodynia were measured using radiant heat and the von Frey filaments test. Formalin-induced spontaneous nociceptive behavior was also investigated. C-Fos expression was assessed by immunohistochemistry. Phosphorylated mitogen-activated protein kinase (p-MAPK) expression was monitored by Western blot assay. Results Intrathecal injection of BmK AGAP reduced chronic constrictive injury-induced neuropathic pain behavior and pain from formalin-induced inflammation, accompanied by decreased expression of spinal p-MAPKs and c-Fos protein. The results of combining low doses of different MAPK inhibitor (U0126, SP600125, or SB203580; 0.1 µg for each inhibitor) with a low dose of BmK AGAP (0.2 µg) suggested that BmK AGAP could potentiate the effects of MAPK inhibitors on inflammation-associated pain. Conclusion Our results demonstrate that intrathecal injection of BmK AGAP produces a sensory-specific analgesic effect via a p-MAPK-dependent mechanism.
Removing duplicated geometries in IFC models using rigid body transformation estimation and flyweight design pattern
Authors: Vonthron Andre , Koch Christian , König Markus 
Published: February 2018

Abstract
Background
The digital process of Building Information Modeling (BIM) involves the creation and modification of CAD-based building models. The complexity of such models has been increasing steadily within the last few years. BIM Models are usually being exchanged using open and standardized data formats. In this context, the Industry Foundation Classes (IFC) are widely used. Therefore, software vendors provide interfaces for dealing with the IFC format. To obtain a high level of data integrity, however, IFC elements are often managed as completely distinct entities, which can result in the creation of multiple copies of identical pieces of information. Since the trend to provide web-based solutions for BIM applications is also becoming increasingly important, especially the conflict between available resource consumption and suitable response times must be considered. Although existing optimization algorithms can reduce the size of an IFC file by analyzing its structure syntactically, there is still the gap to detect identical pieces of geometries that are syntactically distinct. Also, when subsequently merging such geometries, the available sharing concepts must be questioned.

Methods
The contribution of this paper is twofold. On the one hand, we propose an algorithm to retrospectively detect identical geometries by estimating the rigid body transformation. On the other hand, we outline and evaluate the available possibilities for sharing geometries within the IFC data model. The so-called flyweight pattern is applied to provide and maintain the appropriate reuse of identical information.

Results
The methodologies are exemplary demonstrated by modeling and optimizing a typical tunnel lining structure, which contains many repetitive elements. As a result, a noticeable reduction of storage and processing time can be measured.

Conclusions
Establishing BIM in large building projects, where complexity not only depends on variation and geometric detail, but also depends on enormous repetition of these elements, a significant benefit is expected.
Informatics Approaches to Address New Challenges in the Classification of Lymphoid Malignancies
Authors: Jordan Jacob , Goldstein Jordan S. , Jaye David L. , Gurcan Metin , Flowers Christopher R. , Cooper Lee A.D. 
Published: February 2018

Purpose Lymphoid malignancies are remarkably heterogeneous, with variations in outcomes and clinical, biologic, and histologic presentation complicating classification according to the World Health Organization guidelines. Incorrect classification of lymphoid neoplasms can result in suboptimal therapeutic strategies for individual patients and confound the interpretation of clinical trials involving personalized, class-based treatments. This review discusses the potential role of pathology informatics in improving the classification accuracy and objectivity for lymphoid malignancies. Design We identified peer-reviewed publications examining pathology informatics approaches for the classification of lymphoid malignancies, reviewed developments in the lymphoma classification systems, and summarized computational methods for pathologic assessment that can impact practice. Results Computer-assisted pathology image analysis algorithms in lymphoma most commonly have been applied to follicular lymphoma to address biologic heterogeneity and subjectivity in the process of classification. Conclusion Objective methods are available to assist pathologists in lymphoma classification and grading, and have been demonstrated to provide measurable benefits in specific contexts. Future validation and extension of these approaches will require datasets that link high resolution pathology images available for image analysis algorithms with clinical variables and follow up outcomes.