bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology and mortality in bacterial bloodstream infections in patients with hematologic malignancies
Authors: Mert Duygu , Ceken Sabahat , Iskender Gulsen , Iskender Dicle , Merdin Alparslan , Duygu Fazilet , Ertek Mustafa , Altuntas Fevzi 
Published: September 2019

Introduction: Patients with hematological malignancies, who are in the high risk group for infectious complications and bacterial bloodstream infections. The aim of the study evaluated epidemiology and mortality in bacterial bloodstream infections in patients with hematologic malignancies. In addition to determine the risk factors, changes in the distribution and frequency of isolated bacterias.
Methodology: In this retrospective study. There were investigated data from 266 patients with hematological malignancies and bacterial bloodstream infections who were hospitalized between the dates 01/01/2012 and 12/31/2017.
Results: There were 305 blood and catheter cultures in febrile neutropenia attacks in total. In these total attacks, primary bloodstream infections were 166 and catheter-related bloodstream infections were 139. In blood cultures; Escherichia coli and Klebsiella pneumoniae bacteria were detected in 58,0% and 22,9% of the samples, respectively. 52,4% of the cultured Gram-negative bacterias were extended spectrum beta-lactamase (ESBL). Carbapenemase positive culture rate was 17,2% in Gram-negative bacteria cultures. Staphylococcus epidermidis was found in 38,4% of the Gram-positive bacteria cultures. In Gram-positive bacteria; methicillin resistance were detected in 82,2% of the samples. There was a statistically significant relationship between bloodstream infection and disease status. 60 patients with primary bloodstream infections were newly diagnosed.
Conclusions: In patients with hematological malignancies, certain factors in the bloodstream infections increase the mortality rate. With the correction of these factors, the mortality rate in these patients can be reduced. The classification of such risk factors may be an important strategy to improve clinical decision making in high-risk patients, such as patients with hematological malignancies.
HARPP: HARnessing the Power of Power sets for Mining Frequent Itemsets
Authors: Yasir Muhammad , Asif Habib Muhammad , Sarwar Shahzad , Nadeem Faisal Chaudhry Muhammad , Ahmad Mudassar , Jabbar Sohail 
Published: September 2019

Modern algorithms for mining frequent itemsets face noteworthy deterioration of performance when minimum support tends to decrease, especially for sparse datasets. Long-tailed itemsets, frequent itemsets found at lower minimum support, are significant for present-day applications such as recommender systems. In this study, we have developed a novel power set based method named as HARnessing the Power of Power sets (HARPP) for mining frequent itemsets. HARPP iteratively generates power sets to make combinations of overlapping varying-sized subsets of I, where I is a set of items in a large database. Intrinsic feature of creating power sets along with the use of set data structure ensures the agility of HARPP because most of its operations take constant running time. Without storing it entirely in memory, HARPP scans the dataset only once and mines frequent itemsets on the fly. In contrast to state-of-the-art, efficiency of HARPP increases with decrease in minimum support that makes it a viable technique for mining long-tailed itemsets. Performance study shows that HARPP is efficient and scalable, and is faster up to two orders of magnitude than FP-Growth algorithm at lower minimum support particularly when datasets are sparse.
High adoption rates in a new preprint service from Springer Nature and Research Square
Authors: Pattinson Damian 
Published: September 2019

In recent years, funders have increased their support for early sharing of biomedical research through the use of preprints. For most, such as the COAlitionS group of funders (ASAPbio 2019) and the Gates foundation, this takes the form of active encouragement, while for others, it is mandated. But despite these motivations, few authors are routinely depositing their work as a preprint before submitting to a journal.
Some journals have started offering authors the option of posting their work early at the point at which it is submitted for review. These include PLOS, who offer a link to BiorXiv, the Cell journals, who offer SSRN posting through ‘Sneak Peak’, and Nature Communications, who offer posting to any preprint and a link from the journal page called ‘Under Consideration’. Uptake has ranged from 3% for the Nature pilot, to 18% for PLOS (The Official Plos Blog 2018).
In order to encourage more researchers to post their work early, we have been offering authors who submit to BMC Series titles the opportunity to post their work as a preprint on Research Square, a new platform that lets authors share and improve their research. To encourage participation, authors are offered a greater amount of control and transparency over the peer review process if they opt in. First, they are given a detailed peer review timeline which updates in real time every time an event occurs on their manuscript (reviewer invited, reviewer accepts etc). Second, they are encouraged to share their preprint with colleagues, who are able to post comments on the paper. These comments are sent to the editor when they are making their decision. Third, authors can suggest potential peer reviewers, recommendations which are also passed onto the editor to vet and invite.
Together, these incentives have had a positive impact on authors choosing to post a preprint. Among the journals that offer this service, the average opt-in rate is 40%. This translates to over 3,000 manuscripts (as of July 2019) that have been posted to Research Square since the launch of the service in October 2018.
In this talk I will demonstrate the functionality of Research Square, and provide demographic and discipline data on which areas are most and least likely to post.
Fluorescent Carbon‐ and Oxygen‐Doped Hexagonal Boron Nitride Powders as Printing Ink for Anticounterfeit Applications
Authors: Liu Feng , Nattestad Andrew , Naficy Sina , Han Rui , Casillas Gilberto , Angeloski Alexander , Sun Xudong , Huang Zhenguo 
Published: September 2019

AbstractIncreasing demands for optical anticounterfeiting technology require the development of versatile luminescent materials with tunable photoluminescence properties. Herein, a number of fluorescent carbon‐ and oxygen‐doped hexagonal boron nitride (denoted as BCNO) phosphors are found to offer a such high‐tech anticounterfeiting solution. These multicolor BCNO powders, developed in a two‐step process with controlled annealing and oxidation, feature rod‐like particle shape, with varied luminescence properties. Studies of the optical properties of BCNO, along with other characterization, provide insight into this underexplored material. Anticounterfeiting applications are demonstrated with printed patterns which are indistinguishable to the naked eye under visible light but become highly discernible under UV irradiation. The fabricated patterns are demonstrated to be both chemically stable in corrosive environments and physically robust in mechanical bending testing. These properties render BCNO as promising and versatile anticounterfeiting material a wide variety of environments.
The Ultrafast and Continuous Fabrication of a Polydimethylsiloxane Membrane by Ultraviolet‐Induced Polymerization
Authors: Si Zhihao , Li Jingfang , Ma Liang , Cai Di , Li Shufeng , Baeyens Jan , Degrève Jan , Nie Jun , Tan Tianwei , Qin Peiyong 
Published: September 2019

AbstractThe polydimethylsiloxane (PDMS) membrane commonly used for separation of biobutanol from fermentation broth fails to meet demand owing to its discontinuous and polluting thermal fabrication. Now, an UV‐induced polymerization strategy is proposed to realize the ultrafast and continuous fabrication of the PDMS membrane. UV‐crosslinking of synthesized methacrylate‐functionalized PDMS (MA‐PDMS) is complete within 30 s. The crosslinking rate is three orders of magnitude larger than the conventional thermal crosslinking. The MA‐PDMS membrane shows a versatile potential for liquid and gas separations, especially featuring an excellent pervaporation performance for n‐butanol. Filler aggregation, the major bottleneck for the development of high‐performance mixed matrix membranes (MMMs), is overcome, because the UV polymerization strategy demonstrates a freezing effect towards fillers in polymer, resulting in an extremely high‐loading silicalite‐1/MA‐PDMS MMM with uniform particle distribution.
Anion–π Catalysis on Carbon Nanotubes
Authors: Bornhof Anna‐Bea , Vázquez‐Nakagawa Mikiko , Rodríguez‐Pérez Laura , Ángeles Herranz María , Sakai Naomi , Martín Nazario , Matile Stefan , López‐Andarias Javier 
Published: September 2019

AbstractInduced π acidity from polarizability is emerging as the most effective way to stabilize anionic transition states on aromatic π surfaces, that is, anion–π catalysis. To access extreme polarizability, we propose a shift from homogeneous toward heterogeneous anion–π catalysis on higher carbon allotropes. According to benchmark enolate addition chemistry, multi‐walled carbon nanotubes equipped with tertiary amine bases outperform single‐walled carbon nanotubes. This is consistent with the polarizability of the former not only along but also between the tubes. Inactivation by π‐basic aromatics and saturation with increasing catalyst concentration support that catalysis occurs on the π surface of the tubes. Increasing rate and selectivity of existing anion–π catalysts on the surface of unmodified nanotubes is consistent with transition‐state stabilization by electron sharing into the tubes, i.e., induced anion–π interactions. On pristine tubes, anion–π catalysis is realized by non‐covalent interfacing with π‐basic pyrenes.
4‐Methyltetrahydropyran (4‐MeTHP): Application as an Organic Reaction Solvent
Authors: Kobayashi Shoji , Tamura Tomoki , Yoshimoto Saki , Kawakami Takashi , Masuyama Araki 
Published: September 2019

Abstract4‐Methyltetrahydropyran (4‐MeTHP) is a hydrophobic cyclic ether with potential for industrial applications. We herein report, for the first time, a comprehensive study on the performance of 4‐MeTHP as an organic reaction solvent. Its broad application to organic reactions includes radical, Grignard, Wittig, organometallic, halogen‐metal exchange, reduction, oxidation, epoxidation, amidation, esterification, metathesis, and other miscellaneous organic reactions. This breadth suggests 4‐MeTHP can serve as a substitute for conventional ethers and harmful halogenated solvents. However, 4‐MeTHP was found incompatible with strong Lewis acids, and the C−O bond was readily cleaved by treatment with BBr3. Moreover, the radical‐based degradation pathways of 4‐MeTHP, THP and 2‐MeTHF were elucidated on the basis of GC‐MS analyses. The data reported herein is anticipated to be useful for a broad range of synthetic chemists, especially industrial process chemists, when selecting the reaction solvent with green chemistry perspectives.
Synthesis of Thiocyameluric Acid C6N7S3H3, Its Reaction to Alkali Metal Thiocyamelurates and Organic Tris(dithio)cyamelurates
Authors: Posern Christian , Höhne Carl‐Christoph , Böhme Uwe , Vogt Claudia , Kroke Edwin 
Published: September 2019

AbstractThiocyameluric acid C6N7S3H3, the tri‐thio analogue of cyameluric acid, is a key compound for the synthesis of new s‐heptazine (tri‐s‐triazine) derivatives. Here, two different routes for the synthesis of thiocyameluric acid and its reaction to tris(aryldithio)‐ and tris(alkyldithio)cyamelurates C6N7(SSR)3 are reported as well as transformation to alkali metal thiocyamelurates M3[C6N7S3], M=Na, K. These compounds were characterised by FTIR, Raman, solution 13C and 1H NMR spectroscopies, thermal gravimetric analysis (TGA) and elemental analysis. The three (de)protonation steps of thiocyameluric acid were investigated by acid–base titration followed via UV/Vis absorption spectroscopy. While it was not possible to determine the three pKa values, it could be postulated that the acid strength probably increases in the following order: cyanuric acid (C3N3O3H3) < thiocyanuric acid (C3N3S3H3) < cyameluric acid (C6N7O3H3) < thiocyameluric acid (C6N7S3H3). Single crystals of Na3[C6N7S3]⋅10 H2O and K3[C6N7S3]⋅6 H2O were obtained and the structures analyzed by single crystal X‐ray diffraction. Additionally, quantum chemical calculations were performed to get insights into the electronic structure of thiocyameluric acid and to clarify the thiol–thione tautomerism. Based on a comparison of calculated and measured vibrational spectra it can be concluded that thiocyameluric acid and the di‐ and mono‐protonated anions exist in the thione form.
Erufosine (ErPC3) Cationic Prodrugs as Dual Gene Delivery Reagents for Combined Antitumor Therapy
Authors: Gaillard Boris , Seguin Cendrine , Remy Jean‐Serge , Pons Françoise , Lebeau Luc 
Published: September 2019

AbstractSixteen cationic prodrugs of the antitumor alkylphospholipid (APL) erufosine were rationally synthesized to provide original gene delivery reagents with improved cytotoxicity profile. The DNA complexation properties of these cationic lipids were determined and associated transfection rates were measured. Furthermore, the self‐assembly properties of the pro‐erufosine compounds were investigated and their critical aggregation concentration was determined. Their hydrolytic stability under pH conditions mimicking the extracellular environment and the late endosome milieu was measured. Hemolytic activity and cytotoxicity of the compounds were investigated. The results obtained in various cell lines demonstrate that the prodrugs of erufosine display antineoplastic activity similar to that of the parent antitumor drug but are not associated with hemolytic toxicity, which is a dose‐limiting side effect of APLs and a major obstacle to their use in anticancer therapeutic regimen. Furthermore, by using lipoplexes prepared from a prodrug of erufosine and a plasmid DNA encoding a pro‐apoptotic protein (TRAIL), evidence was provided for selective cytotoxicity towards tumor cells while nontumor cells were resistant. This study demonstrates that the combination approach involving well tolerated erufosine cationic prodrugs and cancer gene therapy holds significant promise in tumor therapy.
Mild and Practical Dirhodium(II)/NHPI‐Mediated Allylic and Benzylic Oxidations with Air as the Oxidant
Authors: Wang Yi , Chen Xiaochuan , Jin Hong , Wang Yuanhua 
Published: September 2019

AbstractInvited for the cover of this issue is the group of Hong Jin and Yuanhua Wang at Sichuan University. The image depicts a large reaction beaker, in which the oxidation catalyzed by the dirhodium(II) complexes together with N‐hydroxyphthalimide is taking place, surrounded by a background that evokes an environmentally friendly process. The idea of the illustration comes directly from the experimental equipment, the picture of which appears in the graphical abstract. Read the full text of the article at 10.1002/chem.201902739.
Fe3SnC@CNF: A 3 D Antiperovskite Intermetallic Carbide System as a New Robust High‐Capacity Lithium‐Ion Battery Anode
Authors: Roy Kingshuk , Chavan Vinila , Hossain Sk Mujaffar , Haldar Sattwick , Vaidhyanathan Ramanathan , Ghosh Prasenjit , Ogale Satishchandra B. 
Published: September 2019

AbstractA 3 D intermetallic anti‐perovskite carbide, Fe3SnC, is reported as a Li‐ion battery anode. Single‐phase Fe3SnC showed a reversible Li‐ion capacity of 426 mAh g−1 that increased significantly (600 mAh g−1) upon its in situ synthesis by electrospinning and pyrolysis to render a conducting carbon nanofibre (CNF) based composite. Importantly, the Fe3SnC@CNF composite showed excellent stability in up to 1000 cycles with a remarkable 96 % retention of capacity. The rate performance was equally impressive with a high capacity of 500 mAh g−1 delivered at a high current density of 2 A g−1. An estimation of Li ion diffusion from the electrochemical impedance data showed a major enhancement of the rate by a factor of 2 in the case of Fe3SnC@CNF compared to the single‐phase Fe3SnC sample. Post‐cyclic characterisation revealed that the unit cell was retained despite a volume expansion upon the inclusion of four Li atoms per unit cell, as calculated from the capacity value. The cyclic voltammogram shows four distinctive peaks that could be identified as the sequential incorporation of up to four Li atoms. First‐principles DFT calculations were performed to elucidate the favourable sites for the inclusion of 1–4 Li atoms inside the Fe3SnC unit cell along with the associated strain.
Transcriptional profiling of genes in tongue epithelial tissue from immature and adult rats by the RNA‐Seq technique
Authors: Ke Xiumei , Lin Junzhi , Li Pan , Wu Zhenfeng , Xu Runchun , Ci Zhimin , Yang Ming , Han Li , Zhang Dingkun 
Published: September 2019

AbstractChildren are more sensitive than adults to bitterness and thus dislike bitter tastes more than adults do. However, why children are more sensitive to bitterness has never been revealed. To elucidate the effects of age on taste perception, a double‐bottle preference test was first performed with immature and adult rats. Then, RNA‐Seq analysis was performed on tongues obtained from rats of the same ages as those in the double‐bottle test. The immature rats exhibited a lower consumption rate of bitter solution than the adult rats. Bioinformatics analysis yielded 1,347 differentially expressed genes (DEGs) between male adult rats (MARs, 80 days old) and male immature rats (MIRs, 20 days old) and 380 DEGs between female adult rats (FARs, 80 days old) and female immature rats (FIRs, 20 days old). These DEGs were mainly associated with growth, development, differentiation, and extracellular processes, among other mechanisms. According to Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the DEGs were enriched for bitter taste transduction. Specifically, the Gnb3 and TRPM5 genes were downregulated in FARs compared with FIRs and in MARs compared with MIRs, and the protein expression of TRPM5 was significantly downregulated in MARs compared with MIRs. The data presented herein suggest that transcriptional regulation of taste‐associated signal transduction occurs differently in tongue epithelial tissue of rats at different ages, although additional analyses are needed to confirm this conclusion.
LncRNA NEAT1 promotes autophagy via regulating miR‐204/ATG3 and enhanced cell resistance to sorafenib in hepatocellular carcinoma
Authors: Li Xinyu , Zhou Yong , Yang Liang , Ma Yingbo , Peng Xueqiang , Yang Shuo , Li Hangyu , Liu Jingang 
Published: September 2019

AbstractLong noncoding RNAs (lncRNAs) has been acknowledged in tumorigenesis gradually because of the great importance in different cancers. LncRNA nuclear enriched abundant transcript 1 (NEAT1) is a novel lncRNA and has been reported to promote multiple cancer progression. However, the biological roles of NEAT1 in hepatocellular carcinoma (HCC) is not cleared nowadays. In the present research, the level of NEAT1 was found to be upregulated in HCC by The Cancer Genome Atlas. In addition, NEAT1 expression is negatively correlated with the survival rate in HCC. Further investigation revealed that NEAT1 upregulation inhibited sorafenib efficacy and promoted autophagy. We found that NEAT1 could be a sponge for microRNA‐204 (miR‐204) and inhibits its level to upregulate ATG3 expression. In addition to the above, we demonstrated that miR‐204 mimics also attenuated tumor autophagy. And rescue assays demonstrated that NEAT1 promotes HCC autophagy through modulating miR‐204/ATG3 pathway. Collectively, this study first demonstrated that a novel NEAT1/miR‐204/ATG3 signaling regulates HCC progression.
Home and away: Why do consumers shy away from reporting negative experiences in the peer‐to‐peer realms?
Authors: Osman Hanaa , D'Acunto David , Johns Nick 
Published: September 2019

AbstractThis study investigates how customers use their construct of “home” in evaluating their experience in peer‐to‐peer rented accommodation, as opposed to traditional hotels. The literature has paid considerable attention to people's perceptions of destinations, but almost none to their perceptions of “home” and its complexities whilst visiting a destination. We examine the relationships between the concepts of “home” or “here” represented in peer‐to‐peer accommodation and the construct of “away” or “there” represented in traditional hotels. A mixed‐method approach determines the existence of bias in reporting behavior. Our findings indicate that there is a consistent review gap between institutional actors and peer‐to‐peer actors. Also, consumers of peer‐to‐peer accommodation prefer not to engage in negative reporting if a bond with the host is developed. This perception of a home shapes consumers' relationship with the host and leads to reporting bias. This study provides clear theoretical insights to advance our knowledge about the underlying motives behind reporting behavior of negative experiences. Furthermore, it offers practical implications for both institutional and peer‐to‐peer contexts.
Process models: plans, predictions, proclamations or prophecies?
Authors: Stacey Martin , Eckert Claudia , Hillerbrand Rafaela 
Published: September 2019

AbstractDesign process models have a complex and changing relationship to the processes they model, and mean different things to different people in different situations. Participants in design processes need to understand each other’s perspectives and agree on what the models mean. The paper draws on philosophy of science to argue that understanding a design process model can be seen as an imagination game governed by agreed rules, to envisage what would be true about the world if the model were correct. The rules depend on the syntax and content of the model, on the task the model is used for, and on what the users see the model asbeing. The paper outlines twelve alternative conceptualizations of design process models—frames,pathways,positions,proclamations,projections,predictions,propositions,prophecies,requests,demands,proposals,promises—and discusses when they fit situations that stakeholders in design processes can be in. Articulating how process models are conceptualised can both help to understand how process management works and help to resolve communication problems in industrial practice.
Spiking a Silty-Sand Reference Soil with Bacterial DNA: Limits and Pitfalls in the Discrimination of Live and Dead Cells When Applying Ethidium Monoazide (EMA) Treatment
Authors: Wagner Andreas O. , Praeg Nadine , Illmer Paul 
Published: September 2019

Abstract
In the present study, EMA (ethidium monoazide) treatment was applied to a silty-sand reference soil prior to DNA extraction to enable a differentiation between dead and living cells. For this purpose, a reference soil was spiked with Listeria monocytogenes cells or cell equivalents, respectively. With the purpose of evaluating optimum treatment conditions, different EMA concentrations have been tested. However, the results remained largely inconclusive. Furthermore, varied dark incubation periods allowing EMA to penetrate dead cells did not allow the selective removal of DNA from membrane-compromised cells in downstream analyses. In contrast to undiluted soil, an effect of EMA treatment during DNA extraction could be observed when using a 1:10 dilution of the reference soil; however, the effect has not been sufficiently selective to act on heat-treated cells only. Although the application of EMA to soil requires further evaluation, the procedure harbors future potential for improving DNA-based approaches in microbial ecology studies.