bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finite temperature phase transition in a cross-dimensional triangular lattice
Authors: Jin Shengjie , Guo Xinxin , Peng Peng , Chen Xuzong , Li Xiaopeng , Zhou Xiaoji 
Published: June 2019

Abstract
Atomic many-body phase transitions and quantum criticality have recently attracted much attention in non-standard optical lattices. Here we perform an experimental study of finite temperature superfluid transition of bosonic atoms confined in a three dimensional triangular lattice, whose structure can be continuously deformed to dimensional crossover regions including quasi-one and two dimensions. This non-standard lattice system provides a versatile platform to investigate many-body correlated phases. For the three dimensional case, we find that the finite temperature superfluid transition agrees quantitatively with the Gutzwiller mean field theory prediction, whereas tuning towards reduced dimensional cases, both quantum and thermal fluctuation effects are more dramatic, and the experimental measurement for the critical point becomes strongly deviated from the mean field theory. We characterize the fluctuation effects in the whole dimension crossover process. Our experimental results imply strong many-body correlations in the system beyond mean field description, paving a way to study quantum criticality near Mott-superfluid transition in finite temperature dimension-crossover lattices.
Genetically Engineering Wild Mice to Combat Lyme Disease: An Ecological Perspective
Authors: Snow Allison A 
Published: June 2019

Abstract
Genetic engineering of wild populations has been proposed for reducing human diseases by altering pathogens’ hosts. For example, CRISPR-based genome editing may be used to create white-footed mice (Peromyscus leucopus) that are resistant to the Lyme disease spirochete vectored by blacklegged ticks (Ixodes scapularis). Toward this goal, academic researchers are developing Lyme-resistant and tick-resistant white-footed mice, which are a primary pathogen reservoir for Lyme disease in the United States. If field trials on small, experimental islands are successful, the project would scale up to the larger islands of Nantucket and Martha's Vineyard, Massachusetts, and possibly to the mainland, most likely with a local gene drive to speed the traits’ proliferation, pending approvals from relevant constituents. Despite considerable publicity, this project has yet to be evaluated by independent professional ecologists. In the present article, I discuss key ecological and evolutionary questions that should be considered before such genetically engineered mice are released into natural habitats.
Acquired temozolomide resistance in MGMT-deficient glioblastoma cells is associated with regulation of DNA repair by DHC2
Authors: Yi Guo-zhong , Huang Guanglong , Guo Manlan , Zhang Xi’an , Wang Hai , Deng Shengze , Li Yaomin , Xiang Wei , Chen Ziyang , Pan Jun , Li Zhiyong , Yu Lei , Lei Bingxi , Liu Yawei , Qi Songtao 
Published: June 2019

AbstractThe acquisition of temozolomide resistance is a major clinical challenge for glioblastoma treatment. Chemoresistance in glioblastoma is largely attributed to repair of temozolomide-induced DNA lesions by O6-methylguanine-DNA methyltransferase (MGMT). However, some MGMT-deficient glioblastomas are still resistant to temozolomide, and the underlying molecular mechanisms remain unclear. We found that DYNC2H1 (DHC2) was expressed more in MGMT-deficient recurrent glioblastoma specimens and its expression strongly correlated to poor progression-free survival in MGMT promotor methylated glioblastoma patients. Furthermore, silencing DHC2, both in vitro and in vivo, enhanced temozolomide-induced DNA damage and significantly improved the efficiency of temozolomide treatment in MGMT-deficient glioblastoma. Using a combination of subcellular proteomics and in vitro analyses, we showed that DHC2 was involved in nuclear localization of the DNA repair proteins, namely XPC and CBX5, and knockdown of either XPC or CBX5 resulted in increased temozolomide-induced DNA damage. In summary, we identified the nuclear transportation of DNA repair proteins by DHC2 as a critical regulator of acquired temozolomide resistance in MGMT-deficient glioblastoma. Our study offers novel insights for improving therapeutic management of MGMT-deficient glioblastoma.
The functional neuroanatomy of emotion processing in frontotemporal dementias
Authors: Marshall Charles R , Hardy Christopher J D , Russell Lucy L , Bond Rebecca L , Sivasathiaseelan Harri , Greaves Caroline , Moore Katrina M , Agustus Jennifer L , van Leeuwen Janneke E P , Wastling Stephen J , Rohrer Jonathan D , Kilner James M , Warren Jason D 
Published: June 2019

Abstract
Impaired processing of emotional signals is a core feature of frontotemporal dementia syndromes, but the underlying neural mechanisms have proved challenging to characterize and measure. Progress in this field may depend on detecting functional changes in the working brain, and disentangling components of emotion processing that include sensory decoding, emotion categorization and emotional contagion. We addressed this using functional MRI of naturalistic, dynamic facial emotion processing with concurrent indices of autonomic arousal, in a cohort of patients representing all major frontotemporal dementia syndromes relative to healthy age-matched individuals. Seventeen patients with behavioural variant frontotemporal dementia [four female; mean (standard deviation) age 64.8 (6.8) years], 12 with semantic variant primary progressive aphasia [four female; 66.9 (7.0) years], nine with non-fluent variant primary progressive aphasia [five female; 67.4 (8.1) years] and 22 healthy controls [12 female; 68.6 (6.8) years] passively viewed videos of universal facial expressions during functional MRI acquisition, with simultaneous heart rate and pupillometric recordings; emotion identification accuracy was assessed in a post-scan behavioural task. Relative to healthy controls, patient groups showed significant impairments (analysis of variance models, all P < 0.05) of facial emotion identification (all syndromes) and cardiac (all syndromes) and pupillary (non-fluent variant only) reactivity. Group-level functional neuroanatomical changes were assessed using statistical parametric mapping, thresholded at P < 0.05 after correction for multiple comparisons over the whole brain or within pre-specified regions of interest. In response to viewing facial expressions, all participant groups showed comparable activation of primary visual cortex while patient groups showed differential hypo-activation of fusiform and posterior temporo-occipital junctional cortices. Bi-hemispheric, syndrome-specific activations predicting facial emotion identification performance were identified (behavioural variant, anterior insula and caudate; semantic variant, anterior temporal cortex; non-fluent variant, frontal operculum). The semantic and non-fluent variant groups additionally showed complex profiles of central parasympathetic and sympathetic autonomic involvement that overlapped signatures of emotional visual and categorization processing and extended (in the non-fluent group) to brainstem effector pathways. These findings open a window on the functional cerebral mechanisms underpinning complex socio-emotional phenotypes of frontotemporal dementia, with implications for novel physiological biomarker development.
The Human Intraparietal Sulcus Modulates Task-Evoked Functional Connectivity
Authors: Hwang Kai , Shine James M , Cellier Dillan , D’Esposito Mark 
Published: June 2019

Abstract
Past studies have demonstrated that flexible interactions between brain regions support a wide range of goal-directed behaviors. However, the neural mechanisms that underlie adaptive communication between brain regions are not well understood. In this study, we combined theta-burst transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging to investigate the sources of top-down biasing signals that influence task-evoked functional connectivity. Subjects viewed sequences of images of faces and buildings and were required to detect repetitions (2-back vs. 1-back) of the attended stimuli category (faces or buildings). We found that functional connectivity between ventral temporal cortex and the primary visual cortex (VC) increased during processing of task-relevant stimuli, especially during higher memory loads. Furthermore, the strength of functional connectivity was greater for correct trials. Increases in task-evoked functional connectivity strength were correlated with increases in activity in multiple frontal, parietal, and subcortical (caudate and thalamus) regions. Finally, we found that TMS to superior intraparietal sulcus (IPS), but not to primary somatosensory cortex, decreased task-specific modulation in connectivity patterns between the primary VC and the parahippocampal place area. These findings demonstrate that the human IPS is a source of top-down biasing signals that modulate task-evoked functional connectivity among task-relevant cortical regions.
A Novel, Highly Sensitive Quantitative Polymerase Chain Reaction Assay for the Diagnosis of Subarachnoid and Ventricular Neurocysticercosis and for Assessing Responses to Treatment
Authors: O’Connell Elise M , Harrison Sarah , Dahlstrom Eric , Nash Theodore , Nutman Thomas B 
Published: June 2019

Abstract

Background
Treatment of subarachnoid neurocysticercosis (NCC) is complicated, and assays that can guide treatment are not widely available. The reproducibility and scalability of molecular-based biomarkers would be of great use.

Methods
The Taenia solium genome was mined and primers and probes were designed to target repeats with the highest coverage; the most sensitive, specific, and efficient repeat (TsolR13) was selected for clinical testing. We tested 46 plasma samples and 36 cerebral spinal fluid (CSF) samples taken from patients with subarachnoid or ventricular disease using quantitative polymerase chain reaction (qPCR).

Results
The analytic sensitivity of TsolR13 was 97.3% at 240 attograms (ag) of T. solium genomic DNA and 100% analytic specificity. The clinical sensitivity in detecting active subarachnoid or ventricular disease in symptomatic patients was 100% in CSF and 81.3% in plasma. The predictive ability to distinguish active from cured disease was better for CSF (94.4% of those cured had negative qPCR results) than for plasma (86.7% of those cured tested negative). Some subjects also had plasma DNA detectable intermittently for years after being cured. Overall, the test performance was equivalent to T. solium antigen detection.

Conclusions
A qPCR test for the detection of the highly repetitive Tsol13 sequence has been developed and shown to be highly sensitive and specific for NCC, but also useful as a test of cure in CSF and for the definitive diagnosis of NCC in plasma.
Outcomes of Treatment for Hepatitis C in Primary Care, Compared to Hospital-based Care: A Randomized, Controlled Trial in People Who Inject Drugs
Authors: Wade Amanda J , Doyle Joseph S , Gane Edward , Stedman Catherine , Draper Bridget , Iser David , Roberts Stuart K , Kemp William , Petrie Dennis , Scott Nick , Higgs Peter , Agius Paul A , Roney Janine , Stothers Lisa , Thompson Alexander J , Hellard Margaret E 
Published: June 2019

Abstract

Background
To achieve the World Health Organization hepatitis C virus (HCV) elimination targets, it is essential to increase access to direct-acting antivirals (DAAs), especially among people who inject drugs (PWID). We aimed to determine the effectiveness of providing DAAs in primary care, compared with hospital-based specialist care.

Methods
We randomized PWID with HCV attending primary care sites in Australia or New Zealand to receive DAAs at their primary care site or local hospital (standard of care [SOC]). The primary outcome was to determine whether people treated in primary care had a noninferior rate of sustained virologic response at Week 12 (SVR12), compared to historical controls (consistent with DAA trials at the time of the study design); secondary outcomes included comparisons of treatment initiation, SVR12 rates, and the care cascade by study arm.

Results
We recruited 140 participants and randomized 136: 70 to the primary care arm and 66 to the SOC arm. The SVR12 rate (100%, 95% confidence interval [CI] 87.7–100) of people treated in primary care was noninferior when compared to historical controls (85% assumed). An intention-to-treat analysis revealed that the proportion of participants commencing treatment in the primary care arm (75%, 43/57) was significantly higher than in the SOC arm (34%, 18/53; P &lt; .001; relative risk [RR] 2.48, 95% CI 1.54–3.95), and the proportion of participants with SVR12 was significantly higher in the primary care arm, compared to in the SOC arm (49% [28/57] and 30% [16/53], respectively; P = .043; RR 1.63, 95% CI 1.0–2.65).

Conclusions
Providing HCV treatment in primary care increases treatment uptake and cure rates. Approaches that increase treatment uptake among PWID will accelerate elimination strategies.

Clinical Trials Registration
NCT02555475.
The onset in spring and the end in autumn of the thermal and vegetative growing season affect calving time and reproductive success in reindeer
Authors: Paoli Amélie , Weladji Robert B , Holand Øystein , Kumpula Jouko 
Published: June 2019

AbstractA developing trophic mismatch between the peak of energy demands by reproducing animals and the peak of forage availability has caused many species’ reproductive success to decrease. The match–mismatch hypothesis (MMH) is an appealing concept that can be used to assess such fitness consequences. However, concerns have been raised on applying the MMH on capital breeders such as reindeer because the reliance on maternal capita rather than dietary income may mitigate negative effects of changing phenologies. Using a long-term dataset of reindeer calving dates recorded since 1970 in a semidomesticated reindeer population in Finnish Lapland and proxies of plant phenology; we tested the main hypothesis that the time lag between calving date and the plant phenology in autumn when females store nutrient reserves to finance reproduction would lead to consequences on reproductive success, as the time lag with spring conditions would. As predicted, the reproductive success of females of the Kutuharju reindeer population was affected by both the onset of spring green-up and vegetative senescence in autumn as calves were born heavier and with a higher first-summer survival when the onset of the vegetation growth was earlier and the end of the thermal growing season the previous year was earlier as well. Our results demonstrated that longer plant growing seasons might be detrimental to reindeer’s reproductive success if a later end is accompanied by a reduced abundance of mushrooms.
Safety and efficacy of dronedarone from clinical trials to real-world evidence: implications for its use in atrial fibrillation
Authors: Boriani Giuseppe , Blomström-Lundqvist Carina , Hohnloser Stefan H , Bergfeldt Lennart , Botto Giovanni L , Capucci Alessandro , Lozano Ignacio Fernández , Goette Andreas , Israel Carsten W , Merino José L , Camm A John 
Published: June 2019

Abstract
Efficacy and safety of dronedarone was shown in the ATHENA trial for paroxysmal or persistent atrial fibrillation (AF) patients. Further trials revealed safety concerns in patients with heart failure and permanent AF. This review summarizes insights from recent real-world studies and meta-analyses, including reports on efficacy, with focus on liver safety, mortality risk in patients with paroxysmal/persistent AF, and interactions of dronedarone with direct oral anticoagulants. Reports of rapidly progressing liver failure in dronedarone-prescribed patients in 2011 led to regulatory cautions about potential liver toxicity. Recent real-world evidence suggests dronedarone liver safety profile is similar to other antiarrhythmics and liver toxicity could be equally common with many Class III antiarrhythmics. Dronedarone safety concerns (increased mortality in patients with permanent AF) were raised based on randomized controlled trials (RCT) (ANDROMEDA and PALLAS), but comedication with digoxin may have increased the mortality rates in PALLAS, considering the dronedarone–digoxin pharmacokinetic (PK) interaction. Real-world data on apixaban–dronedarone interactions and edoxaban RCT observations suggest no significant safety risks for these drug combinations. Median trough plasma concentrations of dabigatran 110 mg during concomitant use with dronedarone are at acceptable levels, while PK data on the rivaroxaban–dronedarone interaction are unavailable. In RCTs and real-world studies, dronedarone significantly reduces AF burden and cardiovascular hospitalizations, and demonstrates a low risk for proarrhythmia in patients with paroxysmal or persistent AF. The concerns on liver safety must be balanced against the significant reduction in hospitalizations in patients with non-permanent AF and low risk for proarrhythmias following dronedarone treatment.
Fictitious wave domain modelling and analysis of marine CSEM data
Authors: Lu Jie , Li Yuguo , Du Zhijun 
Published: June 2019

SUMMARY
Modelling marine controlled-source electromagnetic (CSEM) responses in the fictitious time domain is a novel approach, which facilitates the full exploration of EM diffusive properties in the fictitious wave domain (FWD). Concepts, such as reflections, refractions, diffractions and transmissions, which are used for the analysis of elastic wave propagation can thus be adopted in FWD for interpreting CSEM data. In this paper, we use a high-order finite difference time domain (FDTD) algorithm for modelling marine CSEM responses in both the fictitious time domain and the diffusive frequency domain. A complex frequency shifted perfectly matched layer (CFS–PML) boundary condition is adopted to the FDTD modelling. We demonstrate the performance of the CFS–PML boundary condition and validate the high-order FDTD code in the FWD with the half-space sea water model and in the frequency domain with the 1-D canonical reservoir model. We investigate and analyse the propagation characteristics of electromagnetic fields in the FWD, where we apply wave propagation concepts to interpret marine CSEM data. Similarities between wave and field propagations relevant for marine CSEM data are demonstrated through several 1-D to 3-D numerical examples.
Emancipation within Empire: an Algerian Alternative during the Era of Decolonization
Authors: Belmessous Saliha 
Published: June 2019

Abstract
This article aims at shedding new light on the salience of empire as a political idea even at the height of decolonization. It discusses why and how colonial subjects – here Muslim Algerians – would continue, when faced with a choice, to look to empires rather than nation-states. The article focuses on six women and men who, during Algeria’s war of independence, rejected the nation-state as their political horizon and imagined a decolonized empire in which they could pursue their emancipation and that of their people. These individuals pursued various political projects that would reconcile their claims for equality and cultural distinctiveness. Though a great number of pro-French supporters fought with arms alongside the French army, others fought with ideas, producing laws that would establish civil and economic equality. While historians have conventionally focused on materialist reasons to explain the loyalty of colonized peoples to imperial polities, this article considers instead the ideas and ideals that inspired the claims expressed by Muslim Algerians. Only a focus on ideas allows us to understand why people could continue to support the French imperial state despite its being disastrous for their material circumstances.
Catastrophic cerebral infarction during extracorporeal life support due to a rare anomaly in the circle of Willis
Authors: Sonobe Aiko , Kato Hideyuki , Mathis Bryan J , Hiramatsu Yuji 
Published: June 2019

Abstract
During extracorporeal life support (ECLS) in infants, cannulation of the right common carotid artery may result in a devastating ischaemic neurological injury. Herein, we present a case of an infant who encountered bilateral cerebral infarction during ECLS via the right carotid artery due to a rare and tragic anomaly of the circle of Willis. The magnetic resonance angiography complemented computed tomography in diagnosing the infarction and identifying this unique anatomy.
Analysis of energy efficiency improvement of high-tech fabrication plants
Authors: Hu Shih-Cheng , Lin Tee , Fu Ben-Ran , Chang Cheng-Kung , Cheng I-Yun 
Published: June 2019

Abstract
In this study, we developed simulation software for the energy consumption of high-tech fabrication plants. The developed fab energy simulation (FES) featured more detailed characteristics of the subsystems than existing simulation tools. The calculated results of the FES were validated using the annual operating data of a Taiwanese semiconductor manufacturing fab. The measured data indicated three major energy consumers in the studied fab—the process tool, water chiller and clean dry air systems. The annual consumption of electricity calculated with the FES showed a deviation of only −0.73% compared with the measured data. The calculated results exhibited an energy consumption trend that was very similar to the measured data, indicating the reliability of the FES. The FES results also demonstrated excellent agreement with the calculated results of the commercial tool ‘CleanCalc II’. Additionally, the FES was employed to study the energy consumption under different conditions. The results revealed that the energy consumption of the chiller system reduced significantly by 43.7% when the chiller system with a coefficient of performance of 8 was used. This reduction in the energy consumption corresponded to 10% of the total energy consumption in the fab, indicating significant energy-saving potential.
Two-sample statistics based on anisotropic kernels
Authors: Cheng Xiuyuan , Cloninger Alexander , Coifman Ronald R 
Published: June 2019

Abstract
The paper introduces a new kernel-based Maximum Mean Discrepancy (MMD) statistic for measuring the distance between two distributions given finitely many multivariate samples. When the distributions are locally low-dimensional, the proposed test can be made more powerful to distinguish certain alternatives by incorporating local covariance matrices and constructing an anisotropic kernel. The kernel matrix is asymmetric; it computes the affinity between $n$ data points and a set of $n_R$ reference points, where $n_R$ can be drastically smaller than $n$. While the proposed statistic can be viewed as a special class of Reproducing Kernel Hilbert Space MMD, the consistency of the test is proved, under mild assumptions of the kernel, as long as $\|p-q\| \sqrt{n} \to \infty $, and a finite-sample lower bound of the testing power is obtained. Applications to flow cytometry and diffusion MRI datasets are demonstrated, which motivate the proposed approach to compare distributions.