bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health and Demographic Surveillance Systems Within the Child Health and Mortality Prevention Surveillance Network
Authors: Cunningham Solveig A , Shaikh Nida I , Nhacolo Ariel , Raghunathan Pratima L , Kotloff Karen , Naser Abu Mohd , Mengesha Melkamu M , Adedini Sunday A , Misore Thomas , Onuwchekwa Uma U , Worrell Mary Claire , El Arifeen Shams , Assefa Nega , Chowdhury Atique I , Kaiser Reinhard , Madhi Shabir A , Mehta Ashka , Obor David , Sacoor Charfudin , Sow Samba O , Tapia Milagritos D , Wilkinson Amanda L , Breiman Robert F ,   Child Health and Mortality Prevention Surveillance (CHAMPS) Methods Consortium, Agaya Janet , Aol George , Liech Stephen , Oyuga Leonard , Akelo Victor , Barr Beth A Tippett , Zielinski-Gutierrez Emily , Bari Sanwarul , Rahman Qazi Sadequr , Rashid Md. Mamunur , Hossain Tanvir , Bassat Quique , Bassat Quique , Filimone Paulo , Hunguana Aura , Jamisse Edgar , Matsena Teodimiro , Mandomando Inacio , Malheia Arlindo , Mandomando Inacio , Onyango Dickens , Sello Matshidiso , Thaele Dineo , Jambai Amara 
Published: August 2019

Abstract
Health and demographic surveillance systems (HDSSs) provide a foundation for characterizing and defining priorities and strategies for improving population health. The Child Health and Mortality Prevention Surveillance (CHAMPS) project aims to inform policy to prevent child deaths through generating causes of death from surveillance data combined with innovative diagnostic and laboratory methods. Six of the 7 sites that constitute the CHAMPS network have active HDSSs: Mozambique, Mali, Ethiopia, Kenya, Bangladesh, and South Africa; the seventh, in Sierra Leone, is in the early planning stages. This article describes the network of CHAMPS HDSSs and their role in the CHAMPS project. To generate actionable health and demographic data to prevent child deaths, the network depends on reliable demographic surveillance, and the HDSSs play this crucial role.
Water and Filth: Reevaluating the First Era of Sanitary Typhoid Intervention (1840–1940)
Authors: Vanderslott Samantha , Phillips Maile T , Pitzer Virginia E , Kirchhelle Claas 
Published: August 2019

Abstract
While typhoid fever remains an important cause of illness in many low- and middle-income countries, important insights can be learned by exploring the historical experience with typhoid fever in industrialized countries. We used archival research to examine British and American attempts to control typhoid via sanitary interventions from the 1840s to 1940s. First, we assess how varying perceptions of typhoid and conflicts of interest led to a nonlinear evolution of control attempts in Oxford, United Kingdom. Our qualitative analysis shows how professional rivalries and tensions between Oxford’s university and citizens (“gown and town”), as well as competing theories of typhoid proliferation stalled sanitary reform until the provision of cheap external credit created cross-party alliances at the municipal level. Second, we use historical mortality data to evaluate and quantify the impact of individual sanitary measures on typhoid transmission in major US cities. Together a historiographic and epidemiological study of past interventions provides insights for the planning of future sanitary programs.
Early and Successful Combination Antiretroviral Therapy Normalizes Survival Time in Patients Coinfected With Human Immunodeficiency Virus and Human T-cell Lymphotrophic Virus Type 1
Authors: Brites Carlos , Miranda Fernanda , Luz Estela , Netto Eduardo Martins 
Published: August 2019

Abstract

Background
Coinfection with human T-cell lymphotrophic virus type 1 (HTLV-1) is associated with shorter survival for adults and children infected with human immunodeficiency virus (HIV), although the reasons remain a matter of debate. We evaluated the factors associated with survival time in a large cohort of HIV/HTLV-1–coinfected and HIV-monoinfected individuals on combination antiretroviral therapy (cART).

Methods
In a nested, retrospective case-control study (1:1), we reviewed medical records of people with HIV infection on cART in a referral AIDS center in Salvador, Brazil. We matched 149 patients coinfected with HTLV-1 (cases) by age at HIV diagnosis and sex, to an equal number of HTLV-uninfected persons (controls). Death rates, survival time, baseline and current CD4 cell count, last HIV-1 RNA plasma viral load (pVL), and causes of death were compared between groups.

Results
The overall mortality rate was 2.1 person-years (76 deaths, 53 among coinfected patients). Survival time for cases (16.7 ± 0.7 years) was significantly shorter than for controls (18.1 ± 0.4 years; P = .001). Among patients with pVL &gt;50 copies/mL, coinfected patients had a shorter survival time (8.4 ± 0.8 years) than monoinfected ones (12.9 ± 1.4 years; P = .02), regardless of pVL magnitude. However, survival time did not differ for HIV-monoinfected (19.0 ± 0.4 years) or coinfected patients (20.2 ± 0.6 years) presenting with pVL &lt;50 copies/mL (P = .5). Deceased coinfected patients had higher initial CD4 count (417 ± 219 cells) than monoinfected ones with the same outcome (177 ± 160 cells; P = .004), while survivors had similar CD4 cell count at baseline, regardless of HTLV status.

Conclusions
Successful cART is able to normalize survival for coinfected patients and should be introduced for all coinfected patients, regardless of CD4 cell count.
HIV/human T-cell lymphotrophic virus type 1 coinfection is believed to decrease survival of coinfected patients. In this case-control study, we demonstrate that successful combination antiretroviral therapy (last HIV viral load &lt;50 copies/mL) is able to improve survival of coinfected patients to levels observed for those monoinfected.
Perceived Benefits and Challenges of Ebola Preparation Among Hospitals in Developed Countries: A Systematic Literature Review
Authors: Puig-Asensio Mireia , Braun Barbara I , Seaman Aaron T , Chitavi Salome , Rasinski Kenneth A , Nair Rajeshwari , Perencevich Eli N , Lawrence Janna C , Hartley Michael , Schweizer Marin L 
Published: August 2019

Abstract
The 2014–2016 Ebola epidemic in West Africa provided an opportunity to improve our response to highly infectious diseases. We performed a systematic literature review in PubMed, Cochrane Library, CINAHL, EMBASE, and Web of Science of research articles that evaluated benefits and challenges of hospital Ebola preparation in developed countries. We excluded studies performed in non-developed countries, and those limited to primary care settings, the public health sector, and pediatric populations. Thirty-five articles were included. Preparedness activities were beneficial for identifying gaps in hospital readiness. Training improved health-care workers’ (HCW) infection control practices and personal protective equipment (PPE) use. The biggest challenge was related to PPE, followed by problems with hospital infrastructure and resources. HCWs feared managing Ebola patients, affecting their willingness to care for them. Standardizing protocols, PPE types, and frequency of training and providing financial support will improve future preparedness. It is unclear whether preparations resulted in sustained improvements.
Prospero Registration. CRD42018090988.
A risk prediction model in asymptomatic patients with severe aortic stenosis: CURRENT-AS risk score
Authors: Minamino-Muta Eri , Kato Takao , Morimoto Takeshi , Taniguchi Tomohiko , Ando Kenji , Kanamori Norio , Murata Koichiro , Kitai Takeshi , Kawase Yuichi , Miyake Makoto , Izumi Chisato , Mitsuoka Hirokazu , Kato Masashi , Hirano Yutaka , Matsuda Shintaro , Nagao Kazuya , Murakami Tomoyuki , Takeuchi Yasuyo , Yamane Keiichiro , Toyofuku Mamoru , Ishii Mitsuru , Inoko Moriaki , Ikeda Tomoyuki , Ishii Katsuhisa , Hotta Kozo , Jinnai Toshikazu , Kato Yoshihiro , Inuzuka Yasutaka , Maeda Chiyo , Morikami Yuko , Saito Naritatsu , Minatoya Kenji , Kimura Takeshi 
Published: August 2019

Abstract

Aims
Early aortic valve replacement (AVR) might be beneficial in selected high-risk asymptomatic patients with severe aortic stenosis (AS), considering their poor prognosis when managed conservatively. This study aimed to develop and validate a clinical scoring system to predict AS-related events within 1 year after diagnosis in asymptomatic severe AS patients.

Methods and results
We analysed 1274 asymptomatic severe AS patients derived from a retrospective multicentre registry enrolling consecutive patients with severe AS in Japan (CURRENT AS registry), who were managed conservatively and completed 1-year follow-up without AVR. From a randomly assigned derivation set (N = 849), we developed CURRENT AS risk score for the AS-related event (a composite of AS-related death and heart failure hospitalization) within 1 year using a multivariable logistic regression model. The risk score comprised independent risk predictors including left ventricular ejection fraction &lt;60%, haemoglobin ≤11.0 g/dL, chronic lung disease (2 points), diabetes mellitus, haemodialysis, and any concomitant valve disease (1 point). The predictive accuracy of the model was good with the area under the curve of 0.79 and 0.77 in the derivation and validation sets (N = 425). In the validation set, the 1-year incidence of AS-related events was much higher in patients with score ≥2 than in patients with score ≤1 (Score 0: 2.2%, Score 1: 1.9%, Score 2: 13.4%, Score 3: 14.3%, and Score ≥4: 22.7%, P &lt; 0.001).

Conclusion
The CURRENT-AS risk score integrating clinical and echocardiographic factors well-predicted the risk of AS-related events at 1 year in asymptomatic patients with severe AS and was validated internally.
The current state of animal models and genomic approaches towards identifying and validating molecular determinants ofMycobacterium tuberculosisinfection and tuberculosis disease
Authors: Bucsan Allison N , Mehra Smriti , Khader Shabaana A , Kaushal Deepak 
Published: August 2019

ABSTRACTAnimal models are important in understanding both the pathogenesis of and immunity to tuberculosis (TB). Unfortunately, we are beginning to understand that no animal model perfectly recapitulates the human TB syndrome, which encompasses numerous different stages. Furthermore, Mycobacterium tuberculosis infection is a very heterogeneous event at both the levels of pathogenesis and immunity. This review seeks to establish the current understanding of TB pathogenesis and immunity, as validated in the animal models of TB in active use today. We especially focus on the use of modern genomic approaches in these models to determine the mechanism and the role of specific molecular pathways. Animal models have significantly enhanced our understanding of TB. Incorporation of contemporary technologies such as single cell transcriptomics, high-parameter flow cytometric immune profiling, proteomics, proteomic flow cytometry and immunocytometry into the animal models in use will further enhance our understanding of TB and facilitate the development of treatment and vaccination strategies.
Complete Sequence of Succinamopine Ti-Plasmid pTiEU6 Reveals Its Evolutionary Relatedness with Nopaline-Type Ti-Plasmids
Authors: Shao Shuai , van Heusden G Paul H , Hooykaas Paul J J 
Published: August 2019

AbstractAgrobacterium tumefaciens is the etiological agent of plant crown gall disease, which is induced by the delivery of a set of oncogenic genes into plant cells from its tumor-inducing (Ti) plasmid. Here we present the first complete sequence of a succinamopine-type Ti-plasmid. Plasmid pTiEU6 is comprised of 176,375 bp with an overall GC content of 56.1% and 195 putative protein-coding sequences could be identified. This Ti-plasmid is most closely related to nopaline-type Ti-plasmids. It contains a single T-region which is somewhat smaller than that of the nopaline-type Ti-plasmids and in which the gene for nopaline synthesis is replaced by a gene (sus) for succinamopine synthesis. Also in pTiEU6 the nopaline catabolic genes are replaced by genes for succinamopine catabolism. In order to trace the evolutionary origin of pTiEU6, we sequenced six nopaline Ti-plasmids to enlarge the scope for comparison to this class of plasmids. Average nucleotide identity analysis revealed that pTiEU6 was most closely related to nopaline Ti-plasmids pTiT37 and pTiSAKURA. In line with this traces of several transposable elements were present in all the nopaline Ti plasmids and in pTiEU6, but one specific transposable element insertion, that of a copy of IS1182, was present at the same site only in pTiEU6, pTiT37, and pTiSAKURA, but not in the other Ti plasmids. This suggests that pTiEU6 evolved after diversification of nopaline Ti-plasmids by DNA recombination between a pTiT37-like nopaline Ti-plasmid and another plasmid, thus introducing amongst others new catabolic genes matching a new opine synthase gene for succinamopine synthesis.
Determinants of health insurance enrolment in Ghana: evidence from three national household surveys
Authors: Salari Paola , Akweongo Patricia , Aikins Moses , Tediosi Fabrizio 
Published: August 2019

Abstract
In 2003, Ghana implemented a National Health Insurance Scheme (NHIS) to move towards Universal Health Coverage. NHIS enrolment is mandatory for all Ghanaians, but the most recent estimates show that coverage stands under 40%. The evidence on the relationship between socio-economic characteristics and NHIS enrolment is mixed, and comes mainly from studies conducted in a few areas. Therefore, in this study we investigate the socio-economic determinants of NHIS enrolment using three recent national household surveys. We used data from the Ghanaian Demographic and Health Survey conducted in 2014, the Multiple Indicator Cluster Survey conducted in 2011 and the sixth wave of the Ghana Living Standard Survey conducted in 2012–13. Given the multilevel nature of the three databases, we use multilevel logistic regression models to estimate the probability of enrolment for women and men separately. We used three levels of analysis: geographical clusters, household and individual units. We found that education, wealth, marital status—and to some extent—age were positively associated with enrolment. Furthermore, we found that enrolment was correlated with the type of occupation. The analyses of three national household surveys highlight the challenges of understanding the complex dynamics of factors contributing to low NHIS enrolment rates. The results indicate that current policies aimed at identifying and subsidizing underprivileged population groups might insufficiently encourage health insurance enrolment.
Civil society action against transnational corporations: implications for health promotion
Authors: Anaf Julia , Baum Fran , Fisher Matthew , Friel Sharon 
Published: August 2019

Abstract
Transnational corporations (TNCs) shape population health both positively and negatively through their national and international social, political and economic power and influence; and are a vital commercial determinant of health. Individual and group advocacy and activism in response to corporate products, practices or policy influences can mediate negative health impacts. This paper discusses the unequal power relations existing between TNCs that promote their own financial interests, and activists and advocates who support population and environmental health by challenging corporate power. It draws on interview data from 19 respondents who informed 2 health impact assessments conducted on TNCs; 1 from the fast food industry, and 1 from the extractive industries sector. It reveals the types of strategies that civil society organizations (CSOs) have used to encourage TNCs to act in more health promoting ways. It discusses the extent to which these strategies have been effective, and how TNCs have used their power to respond to civil society action. The paper highlights the rewards, and the very real challenges faced by CSOs trying to change TNC practices related to health, within a neoliberal policy environment. It aims to provide evidence for socially oriented actors to inform their advocacy for changes in public policy or corporate practices that can contribute to improving population health and equity and tackling commercial determinants of health.
Transitions and anti-integrable limits for multi-hole Sturmian systems and Denjoy counterexamples
Authors: Chen Yi-Chiuan 
Published: August 2019

Abstract
For a Denjoy homeomorphism $f$ of the circle $S$, we call a pair of distinct points of the $\omega$-limit set $\omega (\,f)$ whose forward and backward orbits converge together a gap, and call an orbit of gaps a hole. In this paper, we generalize the Sturmian system of Morse and Hedlund and show that the dynamics of any Denjoy minimal set of finite number of holes is conjugate to a generalized Sturmian system. Moreover, for any Denjoy homeomorphism $f$ having a finite number of holes and for any transitive orientation-preserving homeomorphism $f_1$ of the circle with the same rotation number $\rho (\,f_1)$ as $\rho (\,f)$, we construct a family $f_\varepsilon$ of Denjoy homeomorphisms of rotation number $\rho (\,f)$ containing $f$ such that $(\omega (\,f_\varepsilon ), f_\varepsilon )$ is conjugate to $(\omega (\,f), f)$ for $0<\varepsilon <\tilde{\varepsilon }<1$, but the number of holes changes at $\varepsilon =\tilde{\varepsilon }$, that $(\omega (\,f_\varepsilon ), f_\varepsilon )$ is conjugate to $(\omega (\,f_{\tilde{\varepsilon }}), f_{\tilde{\varepsilon }})$ for $\tilde{\varepsilon }\leqslant \varepsilon <1$ but $\lim _{\varepsilon \nearrow 1}f_\varepsilon (t)=f_1(t)$ for any $t\in S$, and that $f_\varepsilon$ has a singular limit when $\varepsilon \searrow 0$. We show this singular limit is an anti-integrable limit (AI-limit) in the sense of Aubry. That is, the Denjoy minimal system reduces to a symbolic dynamical system. The AI-limit can be degenerate or nondegenerate. All transitions can be precisely described in terms of the generalized Sturmian systems.
Feasibility of Hepatitis B Vaccination by Microneedle Patch: Cellular and Humoral Immunity Studies in Rhesus Macaques
Authors: Choi Youkyung H , Perez-Cuevas Monica B , Kodani Maja , Zhang Xiugen , Prausnitz Mark R , Kamili Saleem , O’Connor Siobhan M 
Published: August 2019

Abstract

Background
This study evaluated dissolvable microneedle patch (dMNP) delivery of hepatitis B vaccine in rhesus macaques and provides evidence that dMNP delivery elicits seroprotective anti-HBs levels comparable with human seroprotection, potentially useful for hepatitis B birth dose vaccination in resource-constrained regions.

Methods
Sixteen macaques were each vaccinated twice; they were treated in 4 groups, with dMNP delivery of AFV at 24 ± 8 µg (n = 4) or 48 ± 14 µg (n = 4), intramuscular injection of AFV (10 µg; n = 4), or intramuscular injection of AAV (10 µg; n = 4). Levels of antibody to hepatitis B surface antigen (HBsAg) (anti-HBs) and HBsAg-specific T-cell responses were analyzed.

Results
Six of 8 animals with dMNP delivery of AFV had anti-HBs levels ≥10 mIU/mL after the first vaccine dose. After dMNP delivery of AFV, interferon γ, interleukin 2, and interleukin 4 production by HBsAg-specific T cells was detected. A statistically significant positive correlation was detected between anti-HBs levels and cells producing HBsAg-specific interferon γ and interleukin 2 (T-helper 1–type cytokine) and interleukin 4 (T-helper 2–type cytokine) in all anti-HBs–positive animals.

Conclusions
dMNP delivery of AFV can elicit seroprotective anti-HBs levels in rhesus macaques that are correlated with human seroprotection, and it could be particularly promising for birth dose delivery of hepatitis B vaccine in resource-constrained regions.
Teaching Religion and International Relations: Disciplinary, Pedagogical, and Personal Reflections
Authors: Bettiza Gregorio , Abdelkader Deina , Buckley David T , Cesari Jocelyne , Haynes Jeffrey , Sandal Nukhet , Shani Giorgio 
Published: August 2019

AbstractThe study of religion and international religions has witnessed an exponential growth in recent decades. Courses and programs exploring the complex entanglements between faith and global politics have likewise mushroomed around the world. Despite this ferment, reflections on teaching religion and international relations have so far lagged behind. This forum seeks to remedy this general silence. It brings together a diverse range of scholars from a multiplicity of national, religious, methodological, and theoretical backgrounds who teach across a variety of different geographical settings including North America, Europe, and East Asia. Contributors reflect on three broad themes. First, how do we engage with the contested character of religion as a category of analysis and practice, and with the multidisciplinary nature of its study? Second, how does the context within which we operate—be it geographical, cultural, institutional, or historical—influence and shape who, what, and how we teach? Third, how do we address the important and, at times, contentious personal and ethical challenges that our research and teaching on religion and politics inevitably raises in the classroom?
Free Speech and Cheap Talk
Authors: Hemel Daniel , Porat Ariel 
Published: August 2019

Abstract
We present a new framework for analyzing defamation liability that serves both to clarify and complicate understandings of the law’s consequences for speakers, victims, and the marketplace of ideas. In addition to the familiar deterrence and chilling effects, we show how defamation liability can generate a “warming effect,” making statements more credible and potentially raising both the quality and quantity of speech. We also explain how a more plaintiff-friendly liability regime may exacerbate harms to defamation victims. We end by considering the possibility of “self-tailored” defamation law, with victims or speakers selecting the defamation liability regime that applies to them.
Ciliated muconodular papillary tumor of the lung: report of two cases and review of the literature
Authors: Shen Leilei , Lin Jixing , Ren Zhipeng , Wang Bailin , Zhao Kai , Lu Yunlong , Wang Fulin , Zhan Lianbin 
Published: August 2019

Abstract
Ciliated muconodular papillary tumor (CMPT) is a peripheral non-endobronchial lung nodule, consisting of ciliated columnar cells and goblet cells with basaloid cell proliferation. Only about 50 cases confirmed by surgery have been reported in English literature worldwide. We present two surgical cases of CMPT in this report. Two patients presented with abnormal computed tomography findings but no obvious symptoms. The first patient’s intraoperative frozen examination was unable to distinguish benignity from malignancy, and he received lobectomy. The other patient’s intraoperative frozen examination indicated adenocarcinoma, but she received wedge resection for her refusal to lobectomy. The two patients’ postoperative pathological analysis finally confirmed the diagnosis of CMPT. We believe that our cases may be essential for pathologists and surgeons to improve their understanding.