bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interventions in Markets with Adverse Selection: Implications for Discount Window Stigma
Authors: ENNIS HUBERTO M. 
Published: November 2018

AbstractI study the implications for central bank discount window stigma of a workhorse model of adverse selection in financial markets. In the model, firms (banks) need to borrow to finance a productive project. There is limited liability and firms have private information about their ability to repay their debts, which gives rise to the possibility of adverse selection. The central bank can ameliorate the impact of adverse selection by lending to firms. Discount window borrowing is observable and it may be taken as a signal of firms' credit worthiness. Under some conditions, firms borrowing from the discount window may pay higher interest rates to borrow in the market, a phenomenon often associated with the presence of stigma. I discuss these and other outcomes in detail and what they suggest about the relevance of stigma as an empirical phenomenon.
Optimal in‐feed amino acid ratio for laying hens based on deletion method
Authors: Soares Letícia , Sakomura Nilva Kazue , Dorigam Juliano Cesar de Paula , Liebert Frank , Sunder Angela , Nascimento Mariana Quintino do , Leme Bruno Balbino 
Published: November 2018

AbstractA total of 56 Hy‐line W‐36 hens from 28 to 30 weeks were used on nitrogen balance (NB) trial to estimate daily N maintenance requirements (NMR) and the genetic potential for daily N retention (NRmaxT). The treatments consisted of six graded levels of nitrogen in the diets (N1 = 8; N2 = 16; N3 = 24; N4 = 32; N5 = 40; and N6 = 48 g N/kg of feed), formulated using the dilution technique. The regression analyses between nitrogen intake and excretion were performed to fit the exponential function and to determine the NMR = 292 mg/BWkg0.67, which was applied for further calculation of NRmaxT = 1,883 mg/BWkg0.67. A second NB trial was conducted, and a total of 96 Hy‐line W‐36 hens were used in the same period to estimate the ideal amino acid ratio (IAAR). Twelve treatments with eight replicates and one bird per cage were used. A balanced diet (BD) was formulated to meet the IAAR and the requirement of other nutrients for pullets. The limiting diets were formulated diluting BD with cornstarch and refilled with synthetic AAs and other feed ingredients, except for the AA under study. In each trial, the data of nitrogen intake, excretion, deposition and retention were obtained in a NB trial. The IAAR determined by Goettingen approach was Lys 100, Met+Cys 88, Trp 21, Thr 69, Arg 109, Val 90, Ile 75, Leu 127, Phe+Tir 110, Gly+Ser 73 and His 29%. The IAAR determined by Louvain approach was Lys 100, Met+Cys 88, Trp 21, Thr 69, Arg 104, Val 91, Ile 78, Leu 121, Phe+Tir 119, Gly+Ser 77 and His 29%.
High salt diet impairs cerebral blood flow regulation via salt‐induced angiotensin II suppression
Authors: Allen Linda A. , Schmidt James R. , Thompson Christopher T. , Carlson Brian E. , Beard Daniel A. , Lombard Julian H. 
Published: November 2018

AbstractObjectivesThis study sought to determine whether salt‐induced ANG II suppression contributes to impaired CBF autoregulation.MethodsCerebral autoregulation was evaluated with LDF during graded reductions of blood pressure. Autoregulatory responses in rats fed HS (4% NaCl) diet vs LS (0.4% NaCl) diet were analyzed using linear regression analysis, model‐free analysis, and a mechanistic theoretical model of blood flow through cerebral arterioles.ResultsAutoregulation was intact in LS‐fed animals as MAP was reduced via graded hemorrhage to approximately 50 mm Hg. Short‐term (3 days) and chronic (4 weeks) HS diet impaired CBF autoregulation, as evidenced by progressive reductions of laser Doppler flux with arterial pressure reduction. Chronic low dose ANG II infusion (5 mg/kg/min, i.v.) restored CBF autoregulation between the pre‐hemorrhage MAP and 50 mm Hg in rats fed short‐term HS diet. Mechanistic‐based model analysis showed a reduced myogenic response and reduced baseline VSM tone with short‐term HS diet, which was restored by ANG II infusion.ConclusionsShort‐term and chronic HS diet lead to impaired autoregulation in the cerebral circulation, with salt‐induced ANG II suppression as a major factor in the initiation of impaired CBF regulation.
Ultraviolet‐C priming of strawberry leaves against subsequent Mycosphaerella fragariae infection involves the action of reactive oxygen species, plant hormones, and terpenes
Authors: Xu Yanqun , Charles Marie Thérèse , Luo Zisheng , Mimee Benjamin , Tong Zhichao , Véronneau Pierre‐Yves , Roussel Dominique , Rolland Daniel 
Published: November 2018

AbstractUltraviolet‐C (UV‐C) radiation has been reported to induce defence responses to pathogens in growing crops and described as a new environmentally friendly method for disease control. However, whether the effect of the induced defence mechanisms will persist after the stress imposed by UV‐C is alleviated and how these mechanisms interact with pathogen elicitors upon infection have not yet been investigated. Thus, we inoculated strawberry plants with Mycosphaerella fragariae, the causal agent of leaf spot disease, after 5 weeks of repeated UV‐C irradiation treatment (cumulative dose of 10.2 kJ m−2) and investigated the alteration of gene expression and biochemical phenotypes. The results revealed that UV‐C treatment had a significant impact on gene expression in strawberry leaves and led to the overexpression of a set of genes involved in plant–pathogen interaction. UV‐C‐treated leaves displayed a stronger response to infection after inoculation, with reduced symptoms and increases in accumulation of total phenolics and volatile terpenes, higher expression of pathogenesis‐related proteins and the activity of several defence enzymes. This study presumptively describe, for the first time, the involvement of terpenes, reactive oxygen species, and abscisic acid, salicylic acid, jasmonic acid, and their transduction factors, in the network underpinning UV‐C priming of growing crops for improved protection against pathogens.
The Impact of Political Competition on Economic Growth: Evidence from Municipalities in South Africa
Authors: Obikili Nonso 
Published: November 2018

AbstractThis paper examines the impact of political competition on economic growth. In this paper, I show that internal political dynamics, distinct from the type of political system, can having different effects on growth. Using results from the 1994 and 1999 elections in South Africa, I show that municipalities with higher levels of political competition have shown lower levels of economic growth. I use individual level surveys to show that this political competition is associated with political paralysis, dissatisfaction with the current democracy and government and lower optimism about the future.
Using Marketing Science to Understand Contraceptive Demand in High‐Fertility Niger
Authors: Dalglish Sarah L. , Vandermark Jessica , Rossier Clémentine , Kemou Adama , Neighbor Hope 
Published: November 2018

AbstractGlobal initiatives aim to add 120 million new family planning (FP) users by 2020; however supply‐side interventions may be reaching the limits of their effectiveness in some settings. Our case study in Niger used demand analysis techniques from marketing science. We performed a representative survey (N = 2,004) on women's FP knowledge, attitudes, needs, and behaviors, then used latent class analysis to produce a segmentation of women based on their responses. We found that Nigerien women's demand for modern FP methods was low, with majorities aware of modern methods but much smaller proportions considering use, trying modern methods, or using one consistently. We identified five subgroups of women with distinct, internally coherent profiles regarding FP needs, attitudes, and usage patterns, who faced different barriers to adopting or using modern FP. Serving subgroups of women based on needs, values, and underlying beliefs may help more effectively drive a shift in FP behavior.
Lokivetmab therapy for pruritus in a dog with cutaneous mastocytosis
Authors: Meichner Kristina , Kiupel Matti , Kasantikul Tanit , Rakich Pauline , Banovic Frane 
Published: November 2018

BackgroundCutaneous mastocytosis (CM) is a rare disease of dogs characterized by rash, pruritus and proliferation of mast cells in the skin. Oral H1 antihistamines are recommended as the treatment to control pruritus.Hypothesis/ObjectiveTo describe the effective treatment of pruritus associated with CM with lokivetmab in one dog.AnimalA 4‐year‐old, spayed female cross‐bred dog presented with severely pruritic, erythematous to pigmented macules and papules involving the ventral abdomen, interdigital skin, perivulval area and both pinnae; the pruritus had been unresponsive to treatment with antihistamines, prednisone and ciclosporin.Methods and materialsComplete blood count and serum biochemistry, abdominal ultrasound, blood smear and skin cytological evaluation, PCR, histopathological and immunohistochemical examination of skin biopsies.ResultsSkin cytological evaluation revealed high numbers of uniform, heavily granulated mast cells; histopathological findings showed focal dermal proliferations of well‐differentiated, uniform mast cells consistent with a low‐grade mast cell tumour (MCT). Clinical staging revealed that the disease was confined to the skin. Mutations of c‐kit exon 8 and 11 were not detected. Treatment was initiated with anti‐canine‐interleukin (IL)‐31 monoclonal antibody lokivetmab; antihistamines were continued. The dog's pruritus resolved within seven days and was maintained in remission over 15 months with once monthly lokivetmab injections; the skin lesions improved but did not resolve.Conclusion and clinical importanceLokivetmab treatment was effective in resolving and maintaining pruritus remission in this dog with widespread cutaneous mast cell disease. Whether CM in dogs represent a separate entity that should be distinguished from a low‐grade MCT requires further investigation.
Análisis psicométrico y adaptación del test Autoconcepto Forma 5 hacia el judo en una muestra chilena
Authors: Zurita Ortega Felix , González Gonzalez de Mesa Carmen , Martinez Martinez Asuncion , Zafra Santos Edson Orlando , Valdivia Moral Pedro Angel 
Published: November 2018

El objetivo del trabajo es analizar las propiedades psicométricas del cuestionario AF-5 propuesto por García y Musitu (1999), mediante técnicas de tipo exploratorio en judocas de Chile. La muestra de este estudio se encuentra conformada por 148 judocas con rango de edad entre 18 y 40 años, donde 86 participantes fueron hombres y 62 mujeres. El análisis de tipo factorial exploratorio fue llevado a cabo por el programa estadístico FACTOR Analysis. En cuanto a los resultados, estos indicaron que el test propuesto señalaba índices de fiabilidad superiores a α = 0.7. El análisis exploratorio no se ajusta al modelo pentafactorial original, eliminándose el factor familiar. En casi todos los factores, se encuentra correlación significativa en un valor de 99 % (p < 0.01), siendo el valor más alto el establecido al relacionarse la dimensión emocional con la física (0.521).
Combustion Performance Study of Aqueous Aluminum Oxide Nanofluid Blends in Compression Ignition Engine
Authors: Venkatesan S. P. , Kadiresh P. N. 
Published: November 2018

This study attempts to identify the optimum dosing level of aqueous aluminum oxide nanofluid in diesel to improve combustion and engine performance and also to overcome the engine emission issues especially, the oxide of nitrogen, smoke, and the particulate matter. The aqueous aluminum oxide (aluminum oxide nanoparticle aqueous 5 wt % suspension) is used as a nanofluid. The dosing level of nanofluid is varied from 30 cc to 60 cc in steps of 10 cc for the performance study. Fuel blend properties such as calorific value, density, kinematic viscosity, and flash point are determined using ASTM standard test methods. Among all blends, the D+50AN showed a maximum improvement of about 5.9% in brake thermal efficiency (BTE) and remarkable reduction in NOx, smoke, HC, and CO as 15.6%, 22.34%, 31.82%, and 13.79%, respectively, at maximum rated power output.
The potential impact of taxing sugar drinks on health inequality in Indonesia
Authors: Bourke Emily Jane , Veerman J Lennert 
Published: November 2018

BackgroundEvidence suggests reducing consumption of sugar-sweetened beverages is important to reducing weight gain and chronic disease risk. Indonesia’s large population is a growing market for sugar-sweetened beverages. Taxation to reduce consumption is of interest, but considered fiscally regressive. Little is known about differential effects between income groups in low-income countries.MethodsThis modelling study uses a proportional multistate life table to model reduced daily energy intake following a $0.30 per litre tax on sugar-sweetened beverages and subsequent shifts in Body Mass Index (BMI) distribution for income groups in Indonesia. Energy balance equations calculate reduced BMI. Reduced incidence of type 2 diabetes mellitus, ischaemic heart disease and stroke is determined from the relative risk of the BMI shift and subsequent health-adjusted life years gained calculated.ResultsThe tax’s effect was greater for higher income quintiles than lower. Energy intake reduced most in higher income quintiles. Cases of overweight and obesity for women decreased by approximately 15 000 in the lowest income quintile, but 417 000 for the highest. For men, this was 12 000 and 415 000. Over 25 years, 63 000 cases of diabetes were averted in the lowest quintile and 1 487 000 in the highest. Similar magnitudes were observed for stroke and ischaemic heart disease. Tax paid over 25 years was $0.5 billion for the lowest income quintile and $15.1 billion for the highest.ConclusionSugar-sweetened beverage taxation can help to reduce the number of overweight and obese, and prevent over a million cases of diabetes in Indonesia. Higher income groups would benefit more than lower income groups. The tax would raise $920 million in the first year and $27.3 billion over 25 years.
Reducing acute kidney injury incidence and progression in a large teaching hospital
Authors: Sykes Lynne , Sinha Smeeta , Hegarty Janet , Flanagan Emma , Doyle Liam , Hoolickin Chedia , Edwards Lewis , Ferris Paul , Lamerton Elizabeth , Poulikakos Dimitrios , Green Darren , Nipah Robert 
Published: November 2018

Acute kidney injury (AKI) is a common syndrome that is associated with significant mortality and cost. The Quality Improvement AKI Collaborative at Salford Royal Foundation Trust was established to review and improve both the recognition and management of AKI. This was a whole-system intervention to tackle AKI implemented as an alternative to employing separate AKI nurses. Our aims were to reduce the overall incidence of AKI by 10%, to reduce hospital-acquired AKI by 25% and to reduce the progression of AKI from stage 1 to stage 2 or 3 by 50%.From 2014 to 2016, several multifaceted changes were introduced. These included system changes, such as inserting an e-alert for AKI into the electronic patient record, an online educational package and face-to-face teaching for AKI, and AKI addition to daily safety huddles. On 10 Collaborative wards, development of an AKI care bundle via multidisciplinary team (MDT) plan, do, study, act testing occurred.Results showed a 15.6% reduction in hospital-wide-acquired AKI, with a 22.3% reduction on the collaborative wards. Trust-wide rates of progression of AKI 1 to AKI 2 or 3 showed normal variation, whereas there was a 48.5% reduction in AKI progression on the Collaborative wards. This implies that e-alerts were ineffective in isolation. The Collaborative wards’ results were a product of the educational support, bundle and heightened awareness of AKI.A number of acute hospitals have demonstrated impactful successes in AKI reduction centred on a dedicated AKI nurse model plus e-alerting with supporting changes. This project adds value by highlighting another approach that does not require a new post with attendant rolling costs and risks. We believe that our approach increased our efficacy in acute care in our front-line teams by concentrating on embedding improved recognition and actions across the MDT.
Consent and recruitment: the reporting of paediatric trials published in 2012
Authors: Gates Allison , Caldwell Patrina , Curtis Sarah , Dans Leonila , Fernandes Ricardo M , Hartling Lisa , Kelly Lauren E , Williams Katrina , Woolfall Kerry , Dyson Michele P 
Published: November 2018

ObjectivesWe evaluated 300 paediatric trials to determine: the consent and recruitment strategies used, who trial information was targeted to, how incentives were used and if they achieved their recruitment targets.MethodsFor this cross-sectional evaluation, we searched the Cochrane Central Register of Controlled Trials for paediatric trials published in 2012 and randomly selected 300 that reported on outcomes for participants aged ≤21 years. We collected data on consent and recruitment procedures for each trial and undertook descriptive analyses in SPSS statistics V.23.ResultsAll but one trial (99.7%) used a standard recruitment strategy. Most (92%) trials reported that consent was obtained but only 13% reported who obtained consent. Two-thirds (65%) of trials included school-aged participants, and of these 68% reported obtaining assent. Half (50%) of the trials reported who the trial information was targeted to. Most trials (75%) of school-aged participants targeted information towards children or children and their parents. Fourteen per cent of trials reported using incentives, half (50%) of which were in the form of compensation. Only 48% of trials reported sufficient data to determine if their recruitment targets were achieved. Of these, 70% achieved their targets.ConclusionsNotable reporting shortcomings included: how families were recruited into the trial, who obtained consent and/or assent and how, who trial information was directed to, whether incentives were used and sufficient data to determine if the recruitment target was achieved. Forthcoming paediatric-specific reporting standards may improve reporting in this priority area. Our data provide a baseline for ongoing monitoring of the state of the research.
Left atrial pressure is associated with iatrogenic atrial septal defect after mitral valve clip
Authors: Ikenaga Hiroki , Hayashi Atsushi , Nagaura Takafumi , Yamaguchi Satoshi , Yoshida Jun , Rader Florian , Siegel Robert J , Kar Saibal , Shiota Takahiro 
Published: November 2018

ObjectivesMitral valve (MV) clip procedure requires interatrial trans-septal puncture to access the left atrium (LA). Iatrogenic atrial septal defect (iASD) is not uncommon and may remain for a while. However, haemodynamic and echocardiographic determinants of persistent iASD are not well investigated. We sought to find haemodynamic and echocardiographic determinants of iASD after MV clip.MethodsA total of 131 patients with grades 3 to 4+ mitral regurgitation who underwent MitraClip and completed invasive haemodynamic measurement, baseline, 1 month and approximately 12 months of transthoracic echocardiography (TTE) follow-up were retrospectively reviewed.ResultsTTE at 1 month showed persistent iASD in 57% (1M-iASD). Mean LA pressure after clip was significantly higher in patients with 1M-iASD than patients without 1M-iASD (17±6 mm Hg vs 15±5 mm Hg, p=0.01). Among patients with 1M-iASD, 24 patients (35%) had persistent iASD at 12 months (12M-iASD). Mean LA pressure after clip was significantly higher in patients with 12M-iASD than patients without 12M-iASD (19±6 mm Hg vs 16±6 mm Hg, p=0.04). Patients with 12M-iASD did not significantly differ from patients without 12M-iASD in terms of right heart enlargement, estimated systolic pulmonary artery pressure, New York Heart Association functional class and brain natriuretic peptide at 12 months. Logistic regression analysis, however, showed that mean LA pressure after clip was significantly associated with persistent iASD at 12 months in patients with 1M-iASD even after adjustment for cardiac index after clip and the prevalence of mitral regurgitation ≥3+ at 12 months (OR 1.10 per 1 mm Hg, 95% CI 1.01 to 1.21, p=0.04).ConclusionsElevated LA pressure after MV clip was associated with persistent iASD.
Use of a Single CAR T Cell and Several Bispecific Adapters Facilitates Eradication of Multiple Antigenically Different Solid Tumors
Authors: Lee Yong Gu , Marks Isaac , Srinivasarao Madduri , Kanduluru Ananda Kumar , Mahalingam Sakkarapalayam M. , Liu Xin , Chu Haiyan , Low Philip S. 
Published: November 2018

Abstract

Most solid tumors are comprised of multiple clones that express orthogonal antigens, suggesting that novel strategies must be developed in order to adapt chimeric antigen receptor (CAR) T-cell therapies to treat heterogeneous solid tumors. Here, we utilized a cocktail of low-molecular-weight bispecific adapters, each comprised of fluorescein linked to a different tumor-specific ligand, to bridge between an antifluorescein CAR on the engineered T cell and a unique antigen on the cancer cell. This formation of an immunologic synapse between the CAR T cell and cancer cell enabled use of a single antifluorescein CAR T cell to eradicate a diversity of antigenically different solid tumors implanted concurrently in NSG mice. Based on these data, we suggest that a carefully designed cocktail of bispecific adapters in combination with antifluorescein CAR T cells can overcome tumor antigen escape mechanisms that lead to disease recurrence following many CAR T-cell therapies.

Significance:
A cocktail of tumor-targeted bispecific adapters greatly augments CAR T-cell therapies against heterogeneous tumors, highlighting its potential for broader applicability against cancers where standard CAR T-cell therapy has failed.
Individual identification of Duttaphrynus melanostictus (Schneider, 1799) (Amphibia: Anura: Bufonidae) based on dorsal wart patterns
Authors: Bindhani Uddalak Tathagato , Das Abhijit 
Published: November 2018

The dorsal surface of Duttaphrynus melanostictus is covered with keratinized warts of various sizes and shapes. Using combinations and patterns of cranial and mid dorsal warts, we attempted to identify individual toads from a natural population as a non-invasive alternative to existing marking techniques based on toe clipping, pit tagging, and subcutaneous elastomer injections to facilitate population estimates. An accuracy of 100% identification was achieved via this method, making it a potent tool for population studies in this species that is faster, cheaper and less disruptive than standard marking techniques.