bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nuevas estrategias organizacionales que el liderazgo ejercerá en un escenario de trabajo a distancia
Authors: García Valenzuela Ximena Sylvia , Vera Reino José Leonardo , Arteaga María Isabel 
Published: October 2024

El objetivo del artículo fue analizar y dar a conocer cuáles son las estrategias organizacionales que el líder, a partir de la crisis Covid-19, deberá ejercer para la consecución de objetivos empresariales, tomando en cuenta la limitación del trabajo presencial. El estudio se basó en una revisión de literatura, analizando los cambios que debía experimentar el líder actual para enfrentar situaciones de incertidumbre vividas por la crisis Covid-19. Los autores coincidieron en que la crisis Covid-19 generó una serie de cambios organizacionales y dilucidó las competencias requeridas por el líder para organizar y dirigir a su equipo en un escenario de trabajo a distancia, surgiendo así un líder más empático que promueve relaciones basadas en la confianza, transparencia y lealtad. Adicionalmente, se menciona que se desarrolló una cultura digital que favorece la comunicación y compromiso ante un escenario nuevo, mayor individualidad, dada la distancia y la incertidumbre al cambio.
Palabras clave: cambios organizacionales, Covid-19, estrategia organizacional, liderazgo, trabajo virtual
Abstract.The objective of the article was to analyze the organizational strategies that the leader, from the Covid crisis, should exercise in order to achieve business objectives, taking into account the limitation of face-to-face work. The study was based on a literature review, analyzing the changes to be experienced by the current leader to face situations of uncertainty such as those generated by the Covid crisis. The authors agreed that the Covid-19 Crisis prompted organizational changes and has mainly elucidated the competencies that the leader should have to organize and lead his team in a remote work scenario. The emergence of a more empathetic leader, who promotes relationships based on trust, transparency, and loyalty. A digital culture is being installed, which favors communication and commitment in a new scenario of greater individuality given the distance and uncertainty in the face of change.
Keywords: organizational changes, Covid-19, organizational strategy, leadership, virtual work
Biomechanical analysis of different techniques for residual bone defect from tibial plateau bone cyst in total knee arthroplasty
Authors: Liu Dehua , Miao Zhuang , Zhang Wenfei , Liu Chuanwen , Du Longzhuo , Zhu Yuanlong , Luo Yange , Zheng Weibo , Zhou Jianli , Liu Peilai , Li Xuezhou , Li Ming 
Published: October 2024

BackgroundIn patients with tibial plateau bone cysts undergoing total knee arthroplasty (TKA), bone defects commonly occur following tibial plateau resection. Current strategies for addressing these defects include bone grafting, bone cement filling, and the cement-screw technique. However, there remains no consensus on the optimal approach to achieve the best surgical outcomes. This study aims to evaluate the most effective repair method for residual bone defects following tibial plateau bone cyst repair during TKA from a biomechanical perspective.MethodsThe treatment options for tibial plateau bone defects were classified into four categories: no treatment, cancellous bone filling, bone cement filling, and the cement-screw technique. Finite-element analysis (FEA) was employed to evaluate stress distribution and displacement across the models for each treatment group. In addition, static compression mechanical tests were used to assess the displacement of the models within each group.ResultsFEA results indicate that when employing the cement-screw technique to repair tibial plateau bone defects, the maximum stress on the prosthesis and the cement below the prosthesis is minimized, while the maximum stress on the cancellous bone is maximized. And the displacement of each component is minimized. Biomechanical tests results further demonstrate that the displacement of the model is minimized when utilizing the cement-screw technique for tibial plateau bone defects.ConclusionUsing cement-screw technique in treating residual tibial bone defects due to bone cysts in TKA offers optimal biomechanical advantages.
Research hotspots and trends of mesenchymal stem cell-derived extracellular vesicles for drug delivery: a bibliometric and visualization analysis from 2013 to 2023
Authors: Zhao Tianyuan , Mu Yuhao , Deng Haobin , Liang Kaini , Zhou Fanfan , Lin Qiyuan , Cao Fuyang , Zhou Feifei , Yang Zhen 
Published: October 2024

IntroductionOur study aims to provide a comprehensive overview of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in drug delivery research, focusing on the period between 2013 and 2023. Given the increasing global interest in this field, we utilized bibliometric tools to explore publication trends, key contributors, and thematic research clusters.MethodsData was collected from the Web of Science (WoS) database, and an in-depth bibliometric analysis was conducted using VOSviewer. The analysis encompassed bibliographic coupling, co-citation, co-authorship, and co-occurrence trends, offering a structured insight into global research activity. We also employed Citespace to further analyze thematic clusters in this domain.ResultsOur analysis revealed a total of 1,045 publications related to MSC-EVs in drug delivery over the past decade, showing a steady increase in research output. China led in publication count, H-index, prolific authors, and research funding, while the United States ranked highest in total citations, average citation counts, and H-index performance. Pharmaceutics emerged as the leading journal by publication volume, with the Journal of Controlled Release having the strongest total link strength. Top institutions driving research included Shanghai Jiao Tong University, Zhejiang University, and Harvard University. VOSviewer analysis identified four major research clusters: tissue engineering, cancer, neurological diseases, and targeted delivery. Citespace analysis refined this further into ten thematic areas, including differentiation, tissue regeneration, and drug resistance.DiscussionThis bibliometric assessment provides a holistic visualization of the research landscape for MSC-EVs in drug delivery, underlining the significant contributions of China and the United States. Our findings underscore the increasing global importance of MSC-EV research and highlight emerging themes that will likely guide future research directions. The insights from this study offer a foundational framework for identifying nascent frontiers in MSC-EV-based drug delivery.
PtosisDiffusion: a training-free workflow for precisely predicting post-operative appearance in blepharoptosis patients based on diffusion models
Authors: Huang Shenyu , Xie Jiajun , Yang Boyuan , Gao Qi , Ye Juan 
Published: October 2024

PurposeThis study aims to develop a diffusion-based workflow to precisely predict postoperative appearance in blepharoptosis patients.MethodsWe developed PtosisDiffusion, a training-free workflow that combines face mesh with ControlNet for accurate post-operative predictions, and evaluated it using 39 preoperative photos from blepharoptosis patients. The performance of PtosisDiffusion was compared against three other diffusion-based methods: Conditional Diffusion, Repaint, and Dragon Diffusion.ResultsPtosisDiffusion demonstrated superior performance in subjective evaluations, including overall rating, correction, and double eyelid formation. Statistical analyses confirmed that PtosisDiffusion achieved the highest overlap ratio (0.87 ± 0.07) and an MPLPD ratio close to 1 (1.01 ± 0.10). The model also showed robustness in extreme cases, and ablation studies confirmed the necessity of each model component.ConclusionPtosisDiffusion generates accurate postoperative appearance predictions for ptosis patients using only preoperative photographs. Among the four models tested, PtosisDiffusion consistently outperformed the others in both subjective and statistical evaluation.
Multiple Brucella melitensis lineages are driving the human brucellosis epidemic in Shaanxi Province, China: evidence from whole genome sequencing-based analysis
Authors: An Cuihong , Nie Shoumin , Luo Boyan , Zhou Dijia , Wang Wenjing , Sun Yangxin , Fan Suoping , Liu Dongli , Li Zhenjun , Liu Zhiguo , Chang Wenhui 
Published: October 2024

IntroductionHuman brucellosis is a severe public concern in Shaanxi Province, China, and investigating the epidemiological relationship and transmission pattern of B. melitensis is necessary to devise control strategies.MethodsIn this study, a conventional bio-typing approach and whole genome sequencing of single-nucleotide polymorphisms (SNPs) were employed to identify 189 strains.ResultsBased on the conventional bio-typing, 189 Brucella strains were identified as B. melitensis, of which 14 were in bv. 1, 145 were in bv. 3, and 30 were variant, and the Brucella strains were distributed in all ten cities in Shaanxi Province. SNP analysis was used to identify genetic variation in 189 B. melitensis genomes, and maximum-likelihood was used to generate a phylogeny that identified two clades (A and B) and 19 sequence types (STs). The two clades were highly diverse and exclusively of Eastern Mediterranean origin. Clade B contained 18 STs (2-19), with most isolates originating from a broad swath, implying that multiple B. melitensis lineages circulated in Shaanxi. The 19 STs were composed of 3 to 46 strains isolated from different counties and years, suggesting that multiple cross-county brucellosis outbreak events are driven by multiple B. melitensis lineages. Global phylogenetic analysis revealed that clade A was close to GTIIb, and clade B was placed in the GTIIh lineage, expanding the known diversity of B. melitensis from China.ConclusionThe human brucellosis epidemic in Shaanxi is driven by multiple indigenous circulating B. melitensis lineages, the knowledge of which will contribute to devising a control strategy and providing the foundation for a comprehensive regional phylogeny of this important zoonotic pathogen.
Blood pressure and hypertension in older adults with a history of regular cannabis use: findings from the Multi-Ethnic Study of Atherosclerosis
Authors: Corroon Jamie , Bradley Ryan , Allison Matthew A. , Grant Igor 
Published: October 2024

BackgroundObservational evidence investigating associations between cannabis use and blood pressure and hypertension is inconsistent.MethodsCross-sectional data from 3,255 participants at Exam 6 (2016–2018) of the Multi-Ethnic Study of Atherosclerosis (MESA) were analyzed, including self-reported cannabis smoking patterns, standardized measures of systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP; BP collectively), and hypertension. ANCOVA and multivariable relative risk regression models were used to calculate adjusted means for BP and adjusted prevalence ratios (PRs) for prevalent hypertension.ResultsIn fully adjusted ANCOVA models, a history of regular cannabis smoking, when compared to no history, was not significantly associated with increased SBP [mean difference: 0.1 mmHg (95% CI: −1.6–1.9)], DBP [mean difference: 0.5 mmHg (95% CI: −0.3–1.4)], PP [mean difference: −0.5 mmHg (95% CI: −1.8–0.9)], or prevalent hypertension [PR: 1.01 (95% CI: 0.93−1.10)]. Furthermore, no associations were observed for either the duration or recency (in the past month) of cannabis smoking or number of joint/pipe years. Models exploring potential interactions between a history of regular cannabis smoking and age, sex, race/ethnicity, and cigarette smoking status were not significant for either BP or hypertension.ConclusionsIn a cohort of racially and ethnically diverse older adults with a high prevalence of hypertension, no evidence of increased risk due to regular cannabis smoking was found for either blood pressure or hypertension.
Adolescent autistic girls navigating their diagnosis in Swedish secondary school
Authors: Josefsson Helena , Taneja Johansson Shruti 
Published: October 2024

IntroductionAdolescent autistic girls in mainstream schools experience more loneliness and exclusion than their peers. Swedish schools have a long tradition of working towards inclusion but, despite this commitment, these girls are at higher risk of absenteeism and failing to achieve educational objectives. Bearing this in mind, it is important to understand how autistic girls navigate their everyday school life from a first-hand perspective and develop a broader understanding of what shapes their opportunities for and barriers to participation.MethodsThis qualitative study draws on multiple semi-structured interviews with 11 autistic girls, aged 13–15, exploring how they navigate having an autism diagnosis within a Swedish secondary school context.ResultsWhile on a personal level the diagnosis itself was mostly perceived as positive, the girls expressed ambivalence about making sense of it in the school context. The girls expressed awareness of the perceptions and understanding of autism in their school setting, and their consequences in terms of both support and exclusion and stigmatisation. The sense of being perceived by others as different, accompanied by a desire to belong and an awareness of stigma, seemed to have a strong impact on how they navigated everyday school life. This created field of tension between the social context of school, its values and norms, and the girls’ personal experiences and views about autism.DiscussionThe girls’ accounts illustrate the complex reality of their school lives post diagnosis. Valuable implications for practice include the need to work towards a discourse in schools in which differences are seen as natural, and guidance post diagnosis to build the girls’ awareness and understanding and enable them to develop strategies for successfully navigating school.
Exploring diabesity pathophysiology through proteomic analysis using Caenorhabditis elegans
Authors: Subhadra Malaimegu , Mir Dilawar Ahmad , Ankita Koley , Sindunathy Muthukrishnan , Kishore Hambram David , Ravichandiran Velayutham , Balamurugan Krishnaswamy 
Published: October 2024

IntroductionDiabesity, characterized by obesity-driven Type 2 diabetes mellitus (T2DM), arises from intricate genetic and environmental interplays that induce various metabolic disorders. The systemic lipid and glucose homeostasis is controlled by an intricate cross-talk of internal glucose/insulin and fatty acid molecules to maintain a steady state of internal environment.MethodsIn this study, Caenorhabditis elegans were maintained to achieve glucose concentrations resembling the hyperglycemic conditions in diabetic patients to delve into the mechanistic foundations of diabesity. Various assays were conducted to measure intracellular triglyceride levels, lifespan, pharyngeal pumping rate, oxidative stress indicators, locomotor behavior, and dopamine signaling. Proteomic analysis was also performed to identify differentially regulated proteins and dysregulated KEGG pathways, and microscopy and immunofluorescence staining were employed to assess collagen production and anatomical integrity.ResultsWorms raised on diets high in glucose and cholesterol exhibited notably increased intracellular triglyceride levels, a decrease in both mean and maximum lifespan, and reduced pharyngeal pumping. The diabesity condition induced oxidative stress, evident from heightened ROS levels and distinct FT-IR spectroscopy patterns revealing lipid and protein alterations. Furthermore, impaired dopamine signaling and diminished locomotors behavior in diabesity-afflicted worms correlated with reduced motility. Through proteomic analysis, differentially regulated proteins encompassing dysregulated KEGG pathways included insulin signaling, Alzheimer’s disease, and nicotinic acetylcholine receptor signaling pathways were observed. Moreover, diabesity led to decreased collagen production, resulting in anatomical disruptions validated through microscopy and immunofluorescence staining.DiscussionThis underscores the impact of diabesity on cellular components and structural integrity in C. elegans, providing insights into diabesity-associated mechanisms.
Comprehensive multi-omics analysis identifies chromatin regulator-related signatures and TFF1 as a therapeutic target in lung adenocarcinoma through a 429-combination machine learning approach
Authors: Fan Jun , Chen BoGuang , Wu Hao , Liang Xiaoqing , Shen Wen , Miao Xiaye 
Published: October 2024

IntroductionLung cancer is a leading cause of cancer-related deaths, with its incidence continuing to rise. Chromatin remodeling, a crucial process in gene expression regulation, plays a significant role in the development and progression of malignant tumors. However, the role of chromatin regulators (CRs) in lung adenocarcinoma (LUAD) remains underexplored.MethodsThis study developed a chromatin regulator-related signature (CRRS) using a 429-combination machine learning approach to predict survival outcomes in LUAD patients. The CRRS model was validated across multiple independent datasets. We also investigated the impact of CRRS on the immune microenvironment, focusing on immune cell infiltration. To identify potential therapeutic targets, TFF1, a chromatin regulator, was knocked down using siRNA in LUAD cells. We assessed its impact through apoptosis analysis, proliferation assays, and in vivo tumor growth studies. Additional validation was performed using Ki67 expression and TUNEL assays.ResultsThe CRRS accurately predicted survival outcomes and was shown to modulate immune cell infiltration in the tumor microenvironment. High-risk patients demonstrated increased activity in cell cycle regulation and DNA repair pathways, along with distinct mutation profiles and immune responses compared to low-risk patients. TFF1 emerged as a key therapeutic target. Knockdown of TFF1 significantly inhibited LUAD cell proliferation, induced apoptosis, and suppressed in vivo tumor growth. Ki67 and TUNEL assays confirmed the role of TFF1 in regulating tumor growth and cell death.DiscussionThese findings highlight the potential of chromatin regulators in prognostic modeling and immune modulation in LUAD. TFF1 was identified as a promising therapeutic target, suggesting that targeting TFF1 could provide new treatment strategies. Further research is warranted to explore its full potential and therapeutic applicability.
Global research trends in endometrial receptivity from 2000 to 2024: bibliometric analysis
Authors: Liu Ziping , Zhang Zelin , Xie Ping 
Published: October 2024

BackgroundIn recent years, extensive research has been conducted on endometrial receptivity (ER), with rapidly evolving research hotspots and trends. Our study aimed to explore the development of ER research from 2000 to the present and provide insights for future endeavors.Materials and methodsRelevant research publications on ER from 2000 to 2024 were retrieved from the Web of Science Core Collection (WOSCC) database. CiteSpace, VOSviewer and Excel tools were employed to conduct the bibliometric analysis.ResultsA total of 3,354 articles were analyzed, revealing an overall upward trend in annual publication numbers, signifying the increasing attractiveness and research value of this field. Globally, China led with a notable advantage of 1,030 publications, followed by the United States (650) and Spain (251), constituting the first tier of international research. Valencia University topped the list of institutions with 108 publications, closely followed by Shanghai Jiao Tong University with 87. Fertility and Sterility (IF6.6, Q1) is the one with the largest number of publications, accounting for 7.96% of the total publications. The three most co-cited journals were Fertility and Sterility, Biology of Reproduction, and Human Reproduction. A co-citation reference analysis revealed that ER research can be categorized into ten major subfields, including embryo implantation, frozen embryo transfer, integrins, recurrent implantation failure, intrauterine adhesions, etc. Since 2020, the keywords with the strongest citation bursts include repeated implantation failure and frozen.ConclusionThis study employs bibliometric analysis to offer researchers in the field of ER a comprehensive perspective. Since 2000, there has been a remarkable surge in the number of publications in the ER research field. These studies primarily concentrate on delving into the pathophysiological mechanisms of ER, with the primary objective of enhancing clinical pregnancy rates and live birth rates, benefiting more infertile patients. Currently, addressing the ER issues in patients with recurrent implantation failure represents the forefront of research. The primary treatment approaches currently in use involve optimizing embryo transfer timing and employing innovative strategies such as immunotherapy. These cutting-edge analyses not only provide new insights into the treatment of ER but also offer researchers fresh research directions, and staying abreast of the latest trends and advancements in the field.
Case report: Primary cytomegalovirus infection in a patient with late onset multiple sclerosis treated with dimethyl fumarate
Authors: Muñoz Julia Sabin , Santiago Alberto Díaz-De , Escudero José Cebrián , Merino J. A. García 
Published: October 2024

BackgroundTreatment of multiple sclerosis (MS) with delayed-release dimethyl fumarate (DMF) has shown efficacy and safety in clinical trials. However, the occurrence of infectious complications, particularly in elderly patients, remains a concern.MethodsWe present the case of a 63-year-old woman with late-onset MS treated with DMF, who developed a severe primary cytomegalovirus (CMV) infection. DMF was discontinued, and antiviral treatment was initiated, resulting in complete resolution of symptoms.ResultsWhile DMF is generally considered safe in terms of opportunistic infections, this case highlights the possibility of serious infectious complications in eldery DMF-treated patients, even without documented lymphopenia.ConclusionAdvanced age and the associated immunological changes may contribute to an inadequate immune response to MS treatments, highlighting the importance of a careful treatment choice in elderly patients with MS. Further research and specific data on the safety and efficacy of DMF in this population are required to guide clinical decision-making.