bluuebunny/crossref_metadata_2025_split huggingface dataset:
Updatable Signature Scheme With Weakened Token and No‐Directional Key Update
Authors: Zhou Jiacheng , Liu Zhenhua , Wang Baocang 
Published: November 2024

ABSTRACTUpdatable signature (US) resists key compromise attacks and is integral in numerous fields that require authentication. However, previous US schemes granted excessive power to update token, which cannot achieve no‐directional key update. In this paper, we improve Cini et al.'s US scheme by weakening update token. The improvement lies in changing the mode of generating an update token, from the signer alone to the signer and the server cooperatively. Specifically, they first negotiate a secret value, which is then used by the signer to generate an update token. This mode ensures that only the entity who owns the secret value can use the update token to update a signature. Furthermore, we employ indistinguishability obfuscation to minimize information leakage through update token. These advancements make the improved updatable signature scheme achieve no‐directional key update and unidirectional signature update. Finally, we present an enhanced security model, where an adversary is permitted to freely corrupt update tokens and signing keys, except the signing key at challenge epoch, and then prove the improved scheme to be unforgeable based on CDH hardness.
Newly Synthesized Citral Derivatives Serve as Novel Inhibitor in HepG2 Cells
Authors: Gao Wei , Hua Xiaoju , Liao Shengliang , Xiahou Zhikai , Yang Haikuan , Hu Lifang , Chi Yunyang 
Published: November 2024

Abstract2H‐pyran compound 1 synthesized from 6‐methylpyridine‐2,4‐diol and citral, has been used for Cu‐catalyzed N‐arylation with a range of arylboric acids to obtain arylated pyranopyridine core structure derivatives (yield up to 77 %). Among them, compound 3 h exhibited a much better inhibitory effect on HepG2 liver cancer cells compared to citral, and the IC50 value was 5.3 μM following exposure with the newly synthesized derivatives (herein named 3 h for short in this paper), which was lower than that of the cisplatin (6.5 μM). Meanwhile, the cell‐cycle arrest of HepG2 cells occurred in the S phase, and the apoptosis of HepG2 cells was significantly increased with increasing drug concentration. In addition, real‐time fluorescence quantification PCR and Western blotting experiments showed that the expression of apoptotic protein BAX was increased, while the expression of anti‐apoptotic protein BCL2 was inhibited in a dose‐dependent fashion. The results of these experiments indicated that apoptosis was promoted in HepG2 cells via apoptotic signaling pathway activated by 3 h. Furthermore, 3 h effectively decreased the phosphorylation levels of PI3 K, ATK and ERK, resulting in the inhibitions of MAPK/ERK and PI3 K/ATK signaling pathways. Briefly, 3 h has been found to show inhibitory effects on the survival of HepG2 liver cancer cells and may be used as anti‐cancer drug in the future.
Toward Polymeric Room Temperature Acid Generators
Authors: Roberts Joel W. , Lanzendorf Amie N. , Aguilar‐Romero Jazmin E. , Paterson Mara L. , Jalomo Catherine A. , Morado Ephraim G. , Zimmerman Steven C. 
Published: November 2024

AbstractAlthough a variety of acid‐generating molecules have been developed, the formation of toxic byproducts and the need for light‐activation or temperatures that may be incompatible with physiological conditions leave room for the optimization of biocompatible acid‐generators. Herein, we report 4‐hydroxybenzyl chloride derivatives that generate hydrochloric acid via hydrolysis at the benzylic position at room temperature in the absence of light. Utilizing the acetal protected 4‐hydroxybenzyl chloride scaffold, we access a myriad of compounds that generate acid at different rates.
Impact performance comparison of carbon fiber reinforced polyamide 6 and fast‐curing epoxy composites manufactured by resin transfer molding
Authors: Baskaran Maider , de la Calle Amaia , Harismendy Isabel , García‐Arrieta Sonia , Elizetxea Cristina , Aretxabaleta Laurentzi , Aurrekoetxea Jon 
Published: November 2024

AbstractIn the present paper, we manufactured carbon fiber‐reinforced polyamide‐6 composite (CF‐PA6) by resin transfer molding and compared their impact performance with an equivalent automotive grade epoxy‐matrix composite (CF‐Epoxy). Such comparison is pertinent as the new thermoplastic composite will compete with the traditional thermosetting composite, so impact characterization carried out at the same conditions is necessary for evaluating the possibilities of the new material. The energy dissipation capacity of the CF‐PA6 was 27% higher, the maximum impact‐peak load was 5% smaller, and the damage threshold was similar for both composites. Regarding residual post‐impact properties of samples damaged by a 25 J impact energy, CF‐PA6 retained 62% of its stiffness, 84% of its strength and 67% of its energy dissipation capacity. In contrast, CF‐Epoxy retained 46%, 44% and 40% respectively.Highlights
Comparison of impact behavior between CF‐PA6 (RTM) and CF‐Epoxy (RTM).
The damage thresholds of both composites were similar (~2.5 J).
The penetration and perforation thresholds of CF‐PA6 were 48% and 27% higher.
Post‐impact residual property: CF‐PA6 retained 60% of its stiffness.
Damage simulation and experimental analysis of the repaired composite laminates with mortise‐and‐tenon‐lap joint
Authors: Wang Qian , Han Dong , Jia Caixia , Li Zhixin , Qiu Yunpeng , Yan Chao 
Published: November 2024

AbstractIn this paper, a mortise‐and‐tenon structural design was introduced into composite maintenance to create a new type of joint between the repair patches and the parent structure, where both the patches and the structure were carbon fiber composites. Effects of different joints, including step‐lap and mortise‐and‐tenon‐lap joints, on the bending failure of the repaired composites were simulated and then verified through experiments. Results showed that compared with the traditional step‐lap method, the mortise‐and‐tenon connection changed the direction of damage extension from a simple single path to complex multiple paths, which effectively inhibited the damage expansion and enhanced the structural damage tolerance. Therefore, the flexural strength of the repair with the new joint was improved by 19.9%. However, the mortise‐and‐tenon‐lap joint resulted in a poor moisture‐heat resistance of the repaired structure. Interestingly, although the flexural strength of the mortise‐and‐tenon repair decreased by 10.45% after the hygrothermal treatment, it was still higher than that of the step‐lap repair without hygrothermal treatment.Highlights
A novel joint, mortise‐and‐tenon, was introduced into composite maintenance.
Damage extended along multiple paths in the new joint and was inhibited.
Flexural strength of the repair was higher than that of traditional step‐lap repair.
Discriminant analysis of occupational performance characteristics in patients with major depressive disorders and healthy individuals
Authors: Hayasaka Tomonari , Nagashima Izumi , Hoshino Miku , Teruya Koji , Matumoto Yasuyuki , Murao Masami , Maruki Taku , Watanabe Masako , Katagiri Takeshi , Imamura Yayoi , Kurihara Mariko , Oe Yuki , Takaesu Yoshikazu , Tsuboi Takashi , Watanabe Koichiro , Sakurai Hitoshi 
Published: November 2024

AbstractAimAssessing symptoms and daily functioning in patients with major depressive disorder (MDD) can be challenging, as their limited self‐monitoring abilities may result in behavior observed during structured interviews not accurately reflecting their daily lives. This study aimed to determine if specific occupational behaviors could distinguish individuals with MDD from healthy individuals.MethodsBaseline data were collected from medical records and activity programs. Three occupational therapists conducted content analysis to assess occupational performance characteristics. Chi‐squared tests compared the prevalence of these characteristics between patients with MDD and healthy controls. Multivariable logistic regression controlled for potential confounders, with independent variables selected based on clinical relevance and sample size (p < 0.01). Discriminant analysis was used to enhance group differentiation, assessing prediction rates using area under the curve (AUC) values.ResultsA total of 69 occupational performance characteristics were identified, with 12 showing significant differences between 27 patients with MDD and 43 healthy controls. Key discriminators included “Ask questions and consult” (p < 0.001, odds ratio [OR] = 0.051, 95% confidence interval [CI] = 0.009–0.283), “Concentrate on work” (p = 0.003, OR = 0.078, 95% CI = 0.015–0.416), “Choose simple work” (p = 0.004, OR = 17.803, 95% CI = 2.446–129.597), and “Punctual” (p = 0.017, OR = 0.030, 95% CI = 0.002–0.530). Discriminant analysis using these variables yielded a Wilks' λ of 0.493 (p < 0.001), achieving an 88.6% accuracy rate. The receiver operating characteristic curve's AUC value was 0.911 (sensitivity = 95.3%, specificity = 77.8%).ConclusionThis study highlights the importance of occupational performance characteristics in tailoring treatment strategies for MDD, providing insights beyond traditional assessment methods.
Validity of Pharmaceutical Claims Data for Determining Medication Exposure in Long‐Term Care Facilities
Authors: Pearce Emma , Rogers Geraint , Carpenter Lucy , Inacio Maria C. , Caughey Gillian E. , Shoubridge Andrew , Papanicolas Lito , Sluggett Janet K. 
Published: November 2024

ABSTRACTPurposeTo compare the accuracy of pharmaceutical claims with medication administration chart data for individuals in long‐term care facilities (LTCFs).MethodsSecondary analyses of a prospective cohort study (n = 279 residents, 5 LTCFs) were conducted. Details of medications charted for regular administration at study enrollment were extracted from administration charts and coded using Anatomical Therapeutic Chemical (ATC) classification codes. Pharmaceutical claims for government‐subsidized medications dispensed in the 0–30, 0–60, 0–90, 0–120, and 0–180 days before study enrollment were compared to medication chart data (reference standard). Sensitivity, specificity, and positive predictive value (PPV) and 95% CIs were determined at the 3‐ and 7‐digit ATC levels.Results149 (53.4% of total) residents with both medication chart and claims data available were included. The proportion of PPVs ≥ 75% for 3‐digit ATC level medications was 89.4% and 86.1% using exposure windows of 30 and 180‐days for claims, respectively. Using a 120‐day exposure window for claims, sensitivity was highest for diabetes agents, beta‐blocking agents, calcium channel blockers, agents acting on the renin‐angiotensin system, anti‐Parkinson drugs, psychoanaleptics, and airways disease agents (all ≥ 90%) and was lowest for vitamins (1.4%, 95% CI 0–7.7) and mineral supplements (10.3%, 95% CI 2.9–24.2). Specificity was ≥ 85% for all 3‐digit level medications within each exposure window other than antibacterials and analgesics.ConclusionPharmaceutical claims data has good accuracy for determining prescription medication exposure in LTCFs. Exposure windows of 90‐120‐days are generally sufficient for determining exposure although longer periods may be required for large pack sizes.
Vancomycin population pharmacokinetic models: Uncovering pharmacodynamic divergence amid clinicobiological resemblance
Authors: Gandia Peggy , Chaiben Sahira , Fabre Nicolas , Concordet Didier 
Published: November 2024

AbstractVancomycin is an antibiotic used for severe infections. To ensure microbiological efficacy, a ratio of AUC/MIC ≥400 is recommended. However, there is significant interindividual variability in its pharmacokinetic parameters, necessitating therapeutic drug monitoring to adjust dosing regimens and ensure efficacy while avoiding toxicity. Population pharmacokinetic (PopPK) models enable dose personalization, but the challenge lies in the choice of the model to use among the multitude of models in the literature. We compared 18 PopPK models created from populations with the same sociodemographic and clinicobiological characteristics. Simulations were performed for a 47 years old man, weighing 70 kg, with an albumin level of 35.5 g/L, a creatinine clearance of 100 mL/min, an eGFR of 106 mL/min/1.73 m2, and receiving an intravenous infusion of 1 g × 2/day of VCM over 1 h for 48 h. Simulations of time–concentration profiles revealed differences, leading us to determine the probability of achieving microbiological efficacy (AUC/MIC ≥ 400) with each model. Depending on some models, a dose of 1 g × 2/day is required to ensure microbiological efficacy in over 90% of the population, while with the same dose other models do not exceed 10% of the population. To ensure that 90% of the patients are correctly exposed, a dose of vancomycin ranging from 0.9 g × 2/day to 2.2 g × 2/day is necessary a priori depending on the chosen model. These differences raise an issue in choosing a model for performing therapeutic drug monitoring using a PopPK model with or without Bayesian approach. Thus, it is fundamental to evaluate the impact of these differences on both efficacy/toxicity.
Community Water Fluoridation a Cost–Benefit–Risk Consideration
Authors: Osmunson Bill , Cole Griffin 
Published: November 2024

ABSTRACTFor over 70 years, the addition of fluoride to public water as community water fluoridation (CWF or fluoridation) with intent to prevent dental caries continues to be controversial, and risks are seldom included in monetary evaluations. Published operational costs and benefits of fluoridation are used, whereas published and clinical experience treating dental fluorosis are utilized to estimate treatment costs of patient‐perceived dental fluorosis and lost wages from lower IQ (intelligence quotient). Published estimated caries averted, less operational costs at $8 PPPY (per person per year) were used, compensation for functional and cosmetic dental fluorosis $126 PPPY, and lower earnings from presumed harm of developmental neurotoxicity estimated at $438 PPPY. Net loss from CWF is estimated at $556 PPPY, although some individuals will have significantly more or less loss. Previous economic evaluations of fluoridation have estimated caries averted and costs of operations; however, few evaluations include the costs of treating harm. Fluoridation is not cost‐effective if the cost of harm is included. Alternatives for the prevention of dental caries should be promoted, and the cessation of fluoridation is indicated.
Development, Integration, and Field Evaluation of a Dual‐Arm Ridge Cultivation Strawberry Autonomous Harvesting Robot
Authors: Xie Hehe , Zhang Dongxing , Yang Li , Cui Tao , He Xiantao , Zhang Kailiang , Zhang Zhijie 
Published: November 2024

ABSTRACTStrawberry harvesting is a labor‐intensive and time‐consuming task, and the shortage of labor resources and high production costs have made strawberry harvesting robots a focus of attention in both academia and industry. This paper presents a dual‐arm strawberry harvesting robot suitable for ridge cultivation in polytunnels. The coordinated operation of the robot's software and hardware systems enables it to automatically harvest strawberries along the ridge. To ensure the integrity of the fragile fruit, a nondestructive end‐effector was designed that can directly separate and grip the stem, avoiding contact with the fruit itself. Additionally, a method based on composite models was introduced to accurately determine the location and tilt direction of the picking points, to address the randomness in the growth direction of the stems. Furthermore, the modular five degrees‐of‐freedom robotic arm is better suited to the harvesting task requirements. Field evaluation results show that the robot achieves harvesting success rates between 98.4% and 57.4%, and destructive harvesting success rates vary between 98.4% and 75.0% across four scenarios of different complexities. Overall, the success rates for nondestructive and destructive harvesting reach 78.8% and 87.2%, respectively. The average harvesting cycle in the dual‐arm working mode is 4.5 s per berry. Through an in‐depth analysis of the results obtained, this paper also discusses the existing limitations and future research directions.
Collaborative Robotics: Application of Delphi Method
Authors: Salotti Jean‐Marc , Suhir Ephraim 
Published: November 2024

ABSTRACTIn the domain of collaborative robotics, it is often needed to make complex multiparametric choices or assessments that combine heterogeneous criteria, such as task performance, reliability, safety, and ergonomics. The Delphi method, a process of arriving at group consensus by providing experts with rounds of questionnaires, as well as the group response before each subsequent round, can be applied to solve this type of problems. The following Delphi method efforts are addressed in our analysis with application to finding appropriate criteria and their relative weights for the evaluation of the teleoperation task of a robotic platform: (1) Contribution of experts; (2) estimates using student's distribution; and (3) decision making support using Fischer criterion. A consensus emerged among eight experts, who selected the criteria of duration, number of trajectory corrections, and feeling of the operator. Weights have been proposed for each criterion and statistical tools have been used to evaluate the consensus.
T-Cell-Related Skin Inflammatory Flareups with Th1 Polarity in a Patient with Pseudoxanthoma Elasticum
Authors: Rocour Samuel , Vinatier Emeline , Fassot Céline , Dauvé Jonathan , Toutain Agnès , Fronteau Sabrina , Monnier Marine , Preisser Laurence , Croué Anne , Le Saux Olivier , Morel Alain , Delneste Yves , Martin Ludovic 
Published: November 2024

Abstract
Pseudoxanthoma elasticum (PXE) is a genetic disorder characterized by ectopic calcification of tissues rich in elastic fibres (OMIM 264800). To date, PXE is considered a metabolic disease linked to an imbalance between pro- and anti-calcifying factors. The occurrence of sporadic erythematous flareups of PXE skin lesions is a complaint that we heard about on several occasions at the French PXE reference centre. However, this rare clinical aspect had never been extensively studied. We have had the opportunity to investigate a 13-year-old patient experiencing an erythematous flareup of his PXE lesions. We conducted this work to identify what type of inflammation was implicated in his lesions. An incisional skin biopsy on a recent erythematous inguinal PXE lesion was performed and sent for histological and transcriptomic analyses. The findings were compared to a non-erythematous PXE-affected skin biopsy obtained from another young PXE patient. Histological examination revealed perivascular T-cell infiltrates with Th1 polarity and elevated expression of cytotoxicity markers in RNAseq and RT-qPCR analyses. There was no increase in Th17 or Th2 markers. Our findings support the previous evidence of a possible inflammatory component in the development of PXE. Whether Th1-dependent inflammation contributes to the pathology as an active process or is an aggravating factor requires further investigations.
Multifunctional Network‐Shaped Hydrogel Assemblies
Authors: Li Qingyun , Quan Xinyi , Xu Shaoyu , Hu Ziqing , Hu Rui , Li Guangfeng , Han Bin , Ji Xiaofan 
Published: November 2024

AbstractThe previously reported hydrogel assemblies carry bulky shapes, for which the unitary assembly form immensely restricted further applications. Yet there are abundant natural examples of network‐shaped assemblies constructed by animals, of which it is brought up inspirations for constructing hydrogel assemblies. Herein, the network‐shaped assemblies with diverse functions are reported. The precursor solutions are prepared by acrylamide, 4‐acryloylmorpholine, choline chloride, and photo‐initiators. By means of three dimension (3D) printing, the hydrogel networks are formed driven by hydrogen bonds, and then the prepared jagged hydrogel blocks are assembled into network‐shaped hydrogel assembly NSHA‐0 by weaving method. Benefitting from the modifiability of hydrogels, hydrogel assemblies with different properties and functions are prepared by incorporating different functional monomers including ion pair acryloyloxyethyl trimethyl ammonium chloride, and sodium p‐styrenesulfonate, N‐isopropylacrylamide, spiropyran derivative and tetra‐(4‐pyridylphenyl)ethylene. The incorporation of these monomers bestowed the assemblies self‐healing ability, thermo‐responsiveness, ultraviolet‐responsiveness as well as acid‐responsiveness respectively.
A Self‐Calibrating Fluorescent‐Photoacoustic Integrated Probe Enables Fast Visualizing Pancreatic Cancer and Imaging‐Guided Tumor Surgery
Authors: Hu Cong , Liu Hongwen , Zhang Zhipengjun , Li Lingyun , Mao Guo‐jiang , Cheng Wei , Zhou Lei 
Published: November 2024

AbstractPancreatic cancer is known for its high invasiveness and metastasis, making rapid visualization and precise treatment critical for improving patient outcomes. Current diagnostic tools lack abilities to provide rapid and accurate tumor localization, particularly for real‐time intraoperative guidance. To address this gap, the study has developed a novel Förster Resonance Energy Transfer (FRET)‐mediated dual‐ratiometric near‐infrared fluorescence (NIRF)/photoacoustic (PA) bimodal probe, SiRho‐SHD‐NTR, specifically designed for the fast and accurate navigation of pancreatic tumor resection. The probe, due to its excellent binding affinity with nitroreductase (NTR), can rapidly reach response saturation. Cellular experiments demonstrate that the probe rapidly and efficiently penetrates cancer cells, enhancing the effectiveness of PA imaging for preliminary diagnosis and tumor localization, while also enabling the rapid visualization of pancreatic tumors through NIRF imaging. Leveraging the rapid response characteristics of the probe to NTR, the study achieves precise tumor imaging in orthotopic pancreatic cancer mice by spraying the probe, within ≈5 min. More importantly, the probe even allows for the fast visualization of metastatic tumors and fluorescence‐guided surgical resection. It is believed that SiRho‐SHD‐NTR will offer a promising method in the rapid visualization of pancreatic cancer and provide a powerful tool for imaging‐guided tumor surgery, targeting both primary and metastatic tumors.
Well‐Defined Block Copolymer Vitrimer Membranes
Authors: Górecki Radosław , Bhaumik Saibal , Qasem Eyad , Loiola Livia , Emwas Abdul‐Hamid , Ntetsikas Konstantinos , Hadjichristidis Nikos , Nunes Suzana P. 
Published: November 2024

AbstractA well‐defined α,ω‐dialdehyde polyisoprene‐b‐polystyrene block copolymer, synthesized using anionic polymerization high‐vacuum techniques, is employed to prepare vitrimers with tris(2‐aminoethyl)amine as the cross‐linking agent. The vitrimer network, featuring dynamic imine cross‐links, results in robust, flexible, and solvent‐resistant films, which are applicable in thin film composite membranes. These vitrimer membranes, with molecular weight cut‐offs in the nanofiltration range, are successfully used for organic solvent separation and evaluated for gas separation. The cross‐linking density, controlled by the cross‐linker, affects the material's gas permeability and affinity for CO₂. The dynamic nature of the imine cross‐links enables the vitrimer's self‐healing ability, activated by heat treatment at temperatures as low as 50 °C. Additionally, the vitrimer membranes can be reprocessed through solvent dissolution in the presence of the excess cross‐linking agent.