bluuebunny/crossref_metadata_2025_split huggingface dataset:
MUHASEBE MESLEK MENSUPLARININ BAKIŞ AÇISIYLA	VERGİ AFFI UYGULAMALARININ DEĞERLENDİRİLMESİ: TR61 BÖLGESİ’NDE BİR ARAŞTIRMA
Authors: TUĞAY Osman 
Published: June 2019

ÖZ

Bu çalışma, muhasebe
meslek mensuplarının vergi afları konusundaki düşüncelerini belirlemek amacıyla
yapılmıştır. Araştırmanın hedef kitlesini TR61 Bölgesinde bağımsız olarak faaliyet
gösteren Serbest Muhasebeci ve Serbest Muhasebeci Mali Müşavirler
oluşturmaktadır. Araştırmada birincil veri toplama aracı olan anket yöntemi kullanılmıştır.
Verilen cevaplar SPSS 20 programı ile analiz
edilmiştir. Yapılan analizler neticesinde, mükellefe etki, ekonomik ve teşvik
boyutu olmak üzere üç boyut tespit edilmiştir. Söz konusu boyutlarla demografik
özellikler arasındaki ilişikler analiz edilerek aralarında anlamlı bir
farklılık olup olmadığı test edilmiş ve elde edilen bulgular paylaşılmıştır.
AKTIVITAS SITOTOKSIK EKSTRAK DAUN SIRSAK (Annona mucirata L.) TERHADAP SEL KANKER SERVIK
Authors: Maritha Vevi , Ariyanti Ariyanti , Masruriati Eni , Sulistianingsih Eka Nur 
Published: July 2019

Saat ini terapi kanker servik secara umum masih menggunakan kemoterapi. Penggunaan obat-obat seperti doxorubisin, vincristin dan 5 flourourasil yang bekerja dengan menghambat sel yang pertumbuhannya cepat. Obat ini memiliki kekurangan dimana tidak bersifat selektif, sehingga tidak hanya sel kanker saja yang dihambat tetapi sel normal yang pertumbuhannya cepat juga ikut terhambat seperti rambut dan kuku. Oleh karena itu perlu adanya suatu pengembangan obat kanker servik yang selektif, yang hanya menghambat pertumbuhan sel kanker sehingga tidak mengganggu sel normal. Potensi daun sirsak sebagai zat sitotoksik cukup tinggi. Daun sirsak memiliki aktivitas antioksidan mampu menghambat percepatan pertumbuhan pada sel kanker. Pada daun sirsak mengandung acetogenin yang lebih tinggi dari pada bagian lain. Asetogenin mampu menghambat dan membunuh sel kanker secara selektif, yaitu hanya menghambat pertumbuhan sel kanker tanpa menghambat sel normal. Kandungan antioksidan dan acetogenin yang tinggi pada daun sirsak berpotensi untuk dikembangkan menjadi ekstrak sebagai zat sitotoksik terhadap sel kanker servik yang bekerja secara selektif.
Uji aktivitas sitotoksik daun sirsak dilakukan dengan metode MTT. Daun sirsak diekstrak dengan metode maserasi menggunakan pelarut etanol 96%. Kultur sel kanker servik (sel HeLa) di ditransfer sebanyak 1x104 sel/sumuran dalam media kultur lengkap yang terdiri dari FBS sebagai nutrisi utama sel, penisilin-sterptomisin sebagai pencegah kontaminan. bakteri, amfoterizin-B sebagai pencegah kontaminan jamur dan RPMI 1640 sebagai media pembawa (volume masing-masing sumuran 100 μl) kedalam 96-well plate dan diinkubasi dalam inkubator CO25% semalam. Selanjutnya dilakukan pemberian sampel uji dengan seri kadar dan dibuat replikasi tiga kali (triplo), kemudian diinkubasikan kembali semalam. Pengujian hari ke tiga, penambahan reagen MTT, dan setelah 4 jam akan terbentuk kristal formazan pada sel yang masih hidup. Selanjutnya ditambahkan SDS stoper untuk menghentikan reaksi MTT. Kemudian dilakukan pembacaan absorbansi menggunakan elisa reader pada panjang gelombang 595nm. Selanjutnya bersama dengan data kadar sampel yang digunakan dilanjutkan penentuan nilai IC50. Hasil penelitian menunjukkan bahwa ekstrak daun sirsak memiliki potensi terhadap sel kanker servik dengan nilai IC 50 sebesar 337 µg/µL. Ekstrak daun sirsak dapat dikembangkan sebagai alternative terapi bagi pasien kanker serviks.
ORTHOPEDIC TREATMENT OF PATIENTS WITH EDENTULOUS JAWS WITH COMPLETE REMOVABLE PLASTIC DENTURES USING ADHESIVE MATERIAL
Authors: Movchan O.V. 
Published: July 2019

The article reflects that one of the topical problems of orthopedic dentistry is an increase in the functional efficiency of removable dentures and prevention of atrophic changes in the supporting tissues of the prosthetic area by improving the methods of manufacturing prostheses. The solution to this problem is directly dependent on the specific clinical conditions. Under the above clinical conditions of the prosthetic area, the basis of the prosthesis should be differentiated, that is, the corresponding layer of adhesive material must restore the damping properties of the thin mucosal layer with low compliance, the prerequisite being the unloading of zones predisposed to atrophic processes and the load of sites resistant to atrophy.
In the process of adapting patients to prostheses using the adhesive material for up to 3 days, as well as for measuring the values of the chewing pressure and chewing efficiency, the patient did not complain of pain or discomfort.
Cerdas Tanggap dalam Pencegahan Anemia di SMAN 1 Rumbio Jaya Tapung
Authors: Yusmaharani Yusmaharani 
Published: June 2019

ABSTRACT

Anemia is a condition where the hemoglobin (Hb) level in the blood is less than normal. Young women have ten times greater risk of anemia. Anemia can cause fatigue, learning concentration decreases so learning achievement is low, if not handled properly it will continue into adulthood and can increase maternal and infant mortality. The purpose of this community service is to train female students to avoid anemia which can endanger women's reproductive health, especially during pregnancy. Community service was carried out on Maret 1and 16 2018. The method in this service at the first meeting conducted counseling and training on how to deal with anemia, as well as HB examinations to participants. At the second meeting with an interval of 1 week an evaluation of how to treat anemia and Hb examination was conducted. The results of this activity are 99% of students able to repeat how to properly manage healthy eating patterns, and 100% of students who have anemia are no longer anemic. Anemia is still a health problem in Indonesia, this anemia can be caused by the habit of frequently consuming less nutritious foods. Prevention of anemia by regulating diet and a healthy lifestyle is very helpful to overcome anemia. The faster the precaution is taken, the anemia will not worsen the health condition of adolescents in the future.

Keywords: Response, Prevent, Anemia

ABSTRAK

Anemia adalah suatu keadaan dimana kadar hemoglobin (Hb) dalam darah kurang dari normal. Remaja putri memiliki risiko sepuluh kali lebih besar untuk menderita anemia. Anemia dapat menyebabkan lekas lelah, konsentrasi belajar menurun sehingga prestasi belajar rendah, jika tidak ditangani dengan baik akan berlanjut hingga dewasa dan dapat meningkatkan angka kematian ibu, dan bayi. Tujuan dari pengabdian masyarakat ini untuk melatih siswi agar terhindar dari anemia yang dapat membahayakan kesehatan reproduksi wanita, khususnya saat kehamilan. Pengabdian masyarakat ini dilakukan pada tanggal 1 dan 16 Maret 2018. Metode dalam pengabdian ini pada pertemuan pertama melakukan penyuluhan dan pelatihan cara mengatasi anemia, serta pemeriksaan HB kepada peserta. Pada pertemuan kedua dengan selang waktu 1 minggu dilakukan evaluasi cara mengatasi anemia dan pemeriksaan Hb. Hasil dari kegiatan ini adalh 99% siswa mampu mengulangi cara mengatur pola makan yang sehat dengan benar, dan 100% siswa yang mengalami anemia sudah tidak mengalami anemia lagi. Anemia masih menjadi masalah kesehatan di Indonesia, anemia ini dapat disebabkan oleh kebiasaan sering mengkonsumsi makanan yang kurang bergizi. Pencegahan anemia dengan cara pengaturan pola makan dan pola hidup sehat sangat membantu mengatasi anemia. Semakin cepat tindakan pencegahan dilakukan maka anemia tidak akan memperburuk kondisi kesehatan remaja dimasa yang akan datang.

Kata Kunci: Tanggap, Cegah, Anemia
Pelatihan Pemberdayaan Istri Nelayan Melalui Pelatihan Digital Marketing Strategy (DMS) Darah Biru
Authors: Azizah Nisaul 
Published: June 2019

Abstract
The fisherman’s wife was one of the nonproductive community that couldn’t get salary by themselves. The horseshoe crab was the most crab that live in Mayangan’s village. Usually, the community eat this crab and throw the blood away. In fact, this blood, blue colored, has many advantages in pharmacy area that one of ingredient to produce the medicines. The training was needed by community to produce and market the blue blood using digital marketing strategy. The training method covers the formation of caders, the packaging product, creating e-commerce account, the marketing strategy, finacial bookkeeping, and evaluating the use of digital marketing strategy. The training objects were five fisherman’s wives who live in Mayangan Villege and couldn’t earn the salary. After the training held, the community has computer skill and e-commerce account to promote the blood. They also could package the blood that must have good quality in several days. They also were skilled in financial bookkeeping and manage the e-commerce account. Finally, this community could earn the salary by themselves using the production and digital marketing strategy.

Keywords—training, digital marketing strategy, blue blood

Abstrak
Istri nelayan merupakan salah satu masyarakat nonproduktif ditinjau dari kemandirian dalam mendapatkan penghasilan. Darah biru merupakan salah satu komponen pada kepiting tapal kuda yang sangat melimpah di Desa Mayangan. Biasanya, kepiting diolah sebagai masakan dengan proses pembuangan darah biru. Darah biru merupakan salah satu bahan baku obat sehingga diperlukan di bidang farmasi. Pemanfaatan darah biru ini perlu diberikan kepada mitra dan dipasarkan sehingga dapat memberikan penghasilan bagi istri nelayan. Kegiatan pelatihan ini bertujuan untuk memberdayakan istri nelayan agar menjadi masyarakat mandiri dengan memproduksi ekstrak darah biru dan memasarkannya melalui sarana digital. Metode pelaksanaan pelatihan diawali dari sosialisasi, pembentukan kader, strategi pengemasan produk, pembuatan akun e-commerce, strategi pemasaran, strategi pembukuan keuangan, dan evaluasi pemasaran digital. Sasaran pelatihan yaitu lima orang istri nelayan di Desa Mayangan yang tidak mempunyai pekerjaan. Hasil kegiatan ini yaitu adanya kemandirian masyarakat yang ditinjau dari adanya penghasilan yang diperoleh melalui strategi pemasaran darah biru. Penggunaan e-commerce sebagai sarana pemasaran digital dikelola dengan baik sehingga mampu menambah skill mitra di bidang komputasi. Mitra telah mempunyai pembukuan keuangan. Pengkaderan yang dilakukan bertujuan untuk keberlangsungan produksi dan pemasaran darah biru.

Kata kunci—pelatihan, digital marketing strategy, darah biru
WORKSHOP MOBILE LEARNING MENUJU SEKOLAH BERBASIS DIGITAL PADA SMK NEGERI 1 SIAK KECIL
Authors: Yoyon Yoyonefendi , Lusi Lusiana , Romet Rometdo Muzawi 
Published: June 2019

Abstract
Digital school is a school concept that utilizes the development of information technology in its management. The digital school discusses various aspects such as review, administration, grades, counseling (BK) and others. To get to the school, learning media such as Mobile Learning are needed. The Mobile Learning Workshop which was attended by 40 people consisted of students, teachers and school employees. During this Workshop, participants were given material about digital schools, Mobile Learning, IoT and mobile Applications. In the practical session participants create a mobile application using the online-based inventor2 application. The mobile application is made like the application of a school activity schedule. The purpose of this workshop is to increase knowledge and expertise in the mobile field.

Keywords— Mobile Learning, Digital School, SMK N 1 Siak Kecil

Abstrak
Sekolah digital merupakan sebuah konsep sekolah yang memanfatkan perkembangan teknologi informasi dalam pengelolaannya. Sekolah digital meliputi berbagai aspek seperti pengajaran, administrasi, nilai, Bimbingan konseling (BK) dan lainnya. Untuk menuju sekolah tersebut dibutuhkan media Learning seperti Mobile Learning. Workshop Mobile Learning yang diikuti 40 orang terdiri dari siswa, guru dan pegawai sekolah. Selama Workshop ini, peserta diberikan materi tentang sekolah digital, Mobile Learning, IOT dan Aplikasi mobile. Pada sesi pratikum peserta mendapatkan pembuatan aplikasi mobile menggunakan app inventor2 berbasis online. Aplikasi mobile yang dibuat seperti aplikasi jadwal kegiatan sekolah. Tujuan Workshop ini dapat menambah pengetahuan dan keahliaan pada bidang mobile Learning yang dapat meningkat mutu belajar mengajar disekolah.

Kata kunci— Mobile Learning, Sekolah Digital, SMK N 1 Siak Kecil
Jurnal Pengabdian Masyarakat
Authors: Septiani Pipit Eka 
Published: June 2019

Abstrak
Desa Bendar adalah wilayah pesisir di Kecamatan Juwana Kota Pati, sehingga para masyarakat didominasi oleh mata pencaharian sebagai nelayan. Para nelayan berlayar selama 50 mil jauhnya dalam jangka waktu selama kurang lebih 1-3 bulan, kemudian pulang ke daratan membawa hasil tangkapan untuk dilelang di Tempat Pelelangan Ikan (TPI). Istri nelayan yang ditinggal selama 3 bulan mengalami kendala dalam memenuhi kebutuhan hidupnya, sehingga perekonomian keluarga di Desa Bendar menjadi tidak stabil. Oleh karena itu, melalui kegiatan PKM (Program Kreativitas Mahasiswa) ini, kami membentuk sebuah mitra usaha yang beranggotakan 6 orang untuk para istri nelayan yang bertujuan untuk memenuhi kebutuhan hidupnya selama ditinggal berlayar, guna meningkatkan perekonomian keluarga Desa Bendar melalui produksi kerupuk cumi. Kegiatan PKM ini, dimulai dengan koordinasi mitra, Konsultasi dengan Pihak Mitra Desa Bendar, koordinasi dengan anggota mitra, dilanjutkan dengan sosialisasi dan pelatihan produksi kerupuk cumi. Hasil dari kegiatan ini, adalah terbentuknya mitra produksi yang memproduksi kerupuk cumi beserta pemasarannya. Selain itu, produk imi akan diangkat sebagai oleh-oleh khas Desa Bendar, Kampung Nelayan.
HUBUNGAN PENGETAHUAN DAN PERILAKU MEROKOK ANGGOTA KELUARGA DENGAN KEJADIAN ISPA DI DESA BASAAN 1 WILAYAH KERJA PUSKESMAS KECAMATAN RATATOTOK
Authors: Karundeng Yanni , Runtu Lorrien G , Mokoginta Tirsa 
Published: July 2019

Penyakit ISPA (Infeksi Saluran Pernapasan Akut) merupakan salah satu penyakit infeksi yang menular pada pernapasan dan merupakan penyakit infeksi yang masih menjadi isu kesehatan global disemuah Negara. Berdasarkan hasil (Riskesdas, 2013) Infeksi saluran pernapasan akut disebabkan oleh virus atau bakteri, diawali dengan panas disertai salah satu atau lebih gejala : tenggorokan sakit/nyeri menelan, pilek batuk kering atau berdahak. Tujuan penelitian ini untuk menganalisis hubungan pengetahuan dan perilaku merokok anggota keluarga dengan kejadian ISPA di Desa Basaan 1 wilayah kerja Puskesmas Kecamatan Ratatotok Jenis penelitian ini adalah analitik dengan pendekatan Cross sectional yaitu menganalisis hubungan pengetahuan dan perilaku merokok anggota keluarga dengan kejadian ISPA di Desa Basaan 1 wilayah kerja Puskesmas Kecamatan Ratatatotok sebanyak 91 responden yang menjadi subjek sesuai dengan kriteria inklusi. Uji statistic dengan Chi Square dengan tingkat kemaknaan = 0,05 Hasil penelitian menunjukan ada hubungan antara pengetahuan dan perilaku merokok anggota keluarga dengan kejadian ISPA diperoleh = 0,05 p value 0,009 sedangkan perilaku merokok anggota keluarga diperoleh hasil = 0,05 p value 0,05 artinya ada hubungan dengn kejadian ISPA Kesimpulan hasil penelitian membuktikan bahwa ada hubungn antara pengetahuan dan perilaku merokok anggota keluarga dengan kejadian ISPA.
conventional educational with indoor & outdoor modules on disaster preparedness in high school students in Tomohon
Authors: Rondonuwu Rolly Harvie Stevan , Tandiayuk Monica , Sarimin Dorce Sisfiani 
Published: July 2019

Indonesia is one of the countries that experiences quite a lot of natural disasters such as floods, landslides, earthquakes, volcanic eruptions, tsunamis. Increased volcanic volcanic activity in Indonesia's volcanoes allows for potential eruptions in several regions. Disasters that occur in the community require good handling based on targeted disaster management, given that disasters come unexpectedly, for that many things must be prepared carefully including educational interventions on disaster management. This study aims to determine the differences using conventional indoor modules and modules indoor & outdoor on volcanic disaster preparedness in high school students in the city of Tomohon, North Sulawesi.The research design in this study was Quasi experiment one group pre-post-test. In this design high school students were given a pretest before being given education to find out the initial condition, and posttest after being given education, then it would be known whether there was a difference between the scores pretest and posttest . The population in this study were all Lokon high school students, and the sample was 10th grade students totaling 60 people, held in September 2016.The results showed that the experimental group student learning outcomes were better than the control group. The average posttest value of the experimental group students (73.27) was higher than the mean value of the control group posttest (66.17). thus there are differences in scores in the group given the indoor module intervention with the indoor-outdoor module intervention group with a value of p 0.001. (t independent test)Based on the results of the study concluded that there are differences in knowledge between students who are taught using the method indoor learning with students who use methods indoor & outdoor learning. Suggestion: expected teaching methods indoor + outdoor can be developed as a variety of learning methods Keywords: conventional Education, indoor & outdoor modules, Disaster
FAVORABLE IMPACTS OF A FRAGMENT OF ATLANTIC FOREST ON WATER QUALITY IN AN URBAN RIVER IN NORTHEASTERN BRAZIL
Authors: Silva João Carlos de Miranda e , Costa Dimítri de Araújo , Christoffersen Martin Lindsey 
Published: July 2019

The Jaguaribe river is entirely urban in its extent. It follows a convoluted course through the city of João Pessoa, the capital of the State of Paraíba. As with other urban water bodies in Brazil, the quality of its water is compromised by diffuse contaminations arising from a diverse array of poluting souces originating from diverse localities along its course. On the basis of hydric monitoring, accomplishede by the Superintendência de Administração do Meio Ambiente (SUDEMA), it was possible to infer that water quality is best in the stretch contained within the area of environmental preservation “Mata do Buraquinho”, today named Botanic Garden Benjamin Maranhão. This ecosystem, located in the central region of João Pessoa, provides several environmental services to the population living in this city, such as climatic regulation, genetic resources, biodiversity, recreation, and ecotourism, among others. It also produces positive impacts on the water quality of the river flowing through this preservation area. Data from chemical analyses were listed as temporal series (2006 to 2016), making it possible to compare two water sampling stations (JB01 e JB02). Alterations were recorded for some parameters, such as water color, turbidity, number of heat-toletant coliforms, and increase in dissolved water oxigen.
Inducible dominant negative ErbB2 rat spermatogonial line for generation of transgenic rat model and dissecting ERBB2 tyrosine kinase mediated pathways
Authors: Syvyk A.E. , Syvyk T.L. 
Published: July 2019

Summary. Aim: The ERBB2 receptors tyrosine kinase, also known as HER2/Neu, play an essential role in early organism development and modulation of cell behavior in varieties of tissue in an adult organism. Our aim was the generation of transgenic rat spermatogonial line capable of inducible expression of a dominant negative form of the ERBB2 protein in vitro and the transgenic rat as an animal model for dissection of the ERBB2 mediated signaling in vitro and in vivo. Materials and Methods: Donor derived rat spermatogonial stem cells that express green fluorescence protein and inducible ERT2CreERT2 recombinase were modified with Sleeping Beauty transposon-based vector that express truncated kinase deficient form of the ERBB2 receptor upon Cre mediated recombination. Clonally selected spermatogonial cell lines were extensively tested in vitro. Animals were generated via spermatogonia mediated transgenesis by transplantation of clonal cell line into testes of chemically sterilized recipients. Obtained progeny were tested for inducibility in vivo and served as donors of spermatogonia for downstream analysis. Results: We obtained animals and clonally derived spermatogonial stem cell lines that express an inducible dominant negative form of the ERBB2 protein. Isogenic nature of induced and uninduced cells allows most accurate morphological and molecular comparison of cells affected by the interruption of normal function of the ERBB2 receptor and cellular dynamics in vitro and in vivo. Conclusions: Clonally derived spermatogonial stem cell lines that express an inducible dominant negative form of ErbB2 demonstrated an obvious difference in morphological appearance and growth kinetics of induced cells comparing to uninduced ones. Western blot analysis of induced and uninduced cells revealed significant differences in presence and phosphorylation state of several tested important proteins involved in the ERBB2 mediated signal transduction, such as S6 ribosomal protein; AKT (the serine/threonine kinase also known as protein kinase B); and three protein kinases that participate in the RAS-RAF-MEK-ERK signal transduction cascade PRAS40, MEK, ERK1/2.
Clinical and pathological prognostic factors in patients with stage III–IVA-B oral squamous cell carcinoma
Authors: Kravets O.V. , Protsyk V.S. , Burtyn O.V. , Hlynin O.V. , Hurianov V.H. 
Published: July 2019

Summary. The aim of the work was to study clinical and pathological factors affecting the prognosis of the disease in patients with stage III–IVA-B oral squamous cell carcinoma (OSCC). Materials and Methods: A retrospective review of medical records of 234 patients with stage III–IVA-B OSCC was performed in order to study the impact of clinical and pathological factors on disease-free survival (DFS) and overall survival (OS). Results: Multivariable analysis of clinical factors revealed a statistically significant effect of stage IVA-B and the presence of surgical complications on DFS (hazard ratio (HR) = 4.9 (95% confidence interval (CI) 2.9–8.3), p < 0.001; HR = 1.6 (95% CI 1.0–2.6), p = 0.047), respectively. Stage IVA-B, the presence of surgical complications and the retromolar trigone subsite were found to have a statistically significant impact on OS (HR = 4.0 (95% CI 2.5–6.5), p < 0.001; HR = 1.8 (95% CI 1.1–2.8), p = 0.01; HR = 1.9 (95% CI 1.1–3.2), p = 0.02), respectively. Multivariable analysis of pathological factors showed a statistically significant effect of positive resection margins, the multiple lymph node involvement and high-grade tumor on DFS (HR = 3.7 (95% CI 2.0–6.6), p < 0.001; HR = 4.3 (95% CI 2.8–6.7), p < 0.001; HR = 1.6 (95% CI 1.1–2.2), p = 0.01), respectively. Besides, positive resection margins and multiple lymph node involvement were found to cause a statistically significant impact on the OS (HR = 3.6 (95% CI 2.0–6.5), p < 0.001; HR = 3.7 (95% CI 2 5–5.6), p < 0.001), respectively. A tumor grade tended to worsen OS (HR = 1.4 (95% CI 1.0–1.9), p = 0.053). Conclusion: Stage IVA, B, the presence of surgical complications, the retromolar trigone subsite, positive resection margins, multiple lymph node involvements and high-grade tumor were found to be significant clinical and pathological prognostic factors in patients with stage III–IVA-B OSCC.