bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of Death and Major Injury from Natural Winter Hazards in Helicopter and Snowcat Skiing in Canada
Authors: Walcher Matthias , Haegeli Pascal , Fuchs Sven 
Published: July 2019

Introduction Guests and guides partaking in helicopter and snowcat skiing (collectively known as mechanized skiing) are exposed to numerous natural winter hazards that can result in injury or death, but detailed quantitative risk estimates are currently lacking. This lack represents a considerable barrier for evaluating existing risk management practices and implementing evidence-based improvements. Methods We collected historical incident and exposure information from mechanized skiing operations in Canada to perform a retrospective risk analysis. Our analysis dataset includes 713 incidents that resulted in injuries or fatalities among guests or guides during a total of 3,258,000 skier days from the 1970 to 2016 winter season. Results Overall risk of death from natural winter hazards in mechanized skiing was 18.6 fatalities per million skier days (1997–2016). Although the risk of death from avalanches decreased substantially over the entire study period, avalanches remain the largest contributor to the overall risk of death (77%), followed by tree wells and other non–avalanche-related snow immersions. The risk of death from avalanches in snowcat skiing is about half of that in helicopter skiing, but other snow immersion fatalities are more common. The risk of major injury to guests is primarily associated with other falls and collisions. The risk of major injury for guides is higher in snowcat skiing than in helicopter skiing. Conclusion We recommend the design of an industry-wide incident and near-miss reporting system to support evidence-based improvements of safety practices.
Designing Border Carbon Adjustments for Enhanced Climate Action
Authors: Mehling Michael A. , van Asselt Harro , Das Kasturi , Droege Susanne , Verkuijl Cleo 
Published: July 2019

AbstractThe Paris Agreement advances a heterogeneous approach to international climate cooperation. Such an approach may be undermined by carbon leakage—the displacement of emissions from states with more to less stringent climate policy constraints. Border carbon adjustments offer a promising response to leakage, but they also raise concerns about their compatibility with international trade law. This Article provides a comprehensive analysis of border carbon adjustments and proposes a way to design them that balances legal, administrative, and environmental considerations.
The Economic Structure of International Investment Agreements with Implications for Treaty Interpretation and Design
Authors: Sykes Alan O. 
Published: July 2019

AbstractThis Article argues that international investment agreements (IIAs) serve a dual economic function—to discipline host country policies that impose international externalities on foreign investors, and to curtail inefficient risks associated with agency costs, risk aversion, asymmetric information, and time inconsistency problems that uneconomically increase the cost of imported capital in host countries. It draws on the economic analysis to explain central features of IIAs and their evolution over time, and to address various controversial issues in international investment litigation.
Salvage Therapy for Childhood Medulloblastoma: A Single Center Experience
Authors: Kameda-Smith Michelle M. , Wang Alick , Abdulhadi Noora , Voth Rebecca , Sergeant Anjali , Maharaj Arjuna , Bakhshinyan David , Adile Ashley A. , Pai Akshat M. , Ajani Olufemi , Yarascavitch Blake , Alyman M. Cheryl , Duckworth JoAnn , Samaan M. Constantine , Farrokhyar Forough , Singh Sheila K. , Fleming Adam ,   on behalf of the Pediatric Brain Tumour Study Group
Published: July 2019

ABSTRACT:Introduction:Children diagnosed with medulloblastoma (MB) who are refractory to upfront therapy or experience recurrence have very poor prognoses. Although phase I and phase II trials exist, these treatments bear significant treatment-related morbidity and mortality.Methods:A retrospective review of children diagnosed with a recurrence of MB from 2002 to 2015 at McMaster University was undertaken.Results:Recurrent disease in 10 patients involved leptomeningeal dissemination, with 3 experiencing local recurrence. In three recurrent patients the disease significantly progressed, and the children were palliated. The remaining 10 children underwent some form of salvage therapy, including surgical re-resection, radiation, and chemotherapy, either in isolation or in varying combinations. Of the 13 children experiencing treatment-refractory or recurrent disease, 4 are currently alive with a median follow-up of 38.5 months (75.5 months). Of the eight patients with molecular subgrouping data, none of the Wnt MB experienced recurrence.Conclusion:Recurrent MB carried a poor prognosis with a 5-year overall survival (OS) of 18.2% despite the administration of salvage therapy. The upfront therapy received, available treatment, and tolerability of the proposed salvage therapy resulted in significant heterogeneity in the treatment of our recurrent cohort.
A Defense of Intrapersonal Belief Permissivism
Authors: Jackson Elizabeth 
Published: July 2019

AbstractPermissivism is the view that there are evidential situations that rationally permit more than one attitude toward a proposition. In this paper, I argue for Intrapersonal Belief Permissivism (IaBP): that there are evidential situations in which a single agent can rationally adopt more than one belief-attitude toward a proposition. I give two positive arguments for IaBP; the first involves epistemic supererogation and the second involves doubt. Then, I show how these arguments give intrapersonal permissivists a distinct response to the toggling objection. I conclude that IaBP is a view that philosophers should take seriously.
Revisiting the fraud exception: a critique of United City Merchants v Royal Bank of Canada 40 years on
Authors: Richards Katie 
Published: July 2019

AbstractMuch has changed in the four decades since United City Merchants v Royal Bank of Canada, in which Lord Diplock established the fraud exception in transactions financed by documentary credit. In particular, the introduction of the UCP 600, case law on nullity documents and amendment to the American fraud exception justify a reconsideration of both the policy arguments underpinning Lord Diplock's rule and the fate of documents known to be forged or null at the time of presentation. Accordingly, two arguments are made in this paper. First, a consideration of the broader exception in the US should prompt a modern Supreme Court to re-examine his Lordship's insistence that a narrow exception was required to preserve the efficiency of the credit mechanism. In addition, it further argues that banks should be entitled to reject known nullities and forgeries as non-complying. This argument would reinstate the doctrine of strict compliance, which was overlooked in United City Merchants, and is based on the clarified definitions in the UCP 600, more recent judicial consideration of nullities and the existence of the ICC's International Maritime Bureau.
Transient setting of relativistic ponderomotive non-linearity and filamentation of ultra-short laser pulses in collisionless plasmas
Authors: Sharma R.P. , Kumar Narender , Uma R. , Singh Ram Kishor , Gupta P.K. 
Published: July 2019

AbstractWe study the setting up of relativistic ponderomotive non-linearity in an under-dense collisionless cold plasma. Using the fluid model, coupled system of equations of the laser beam and electron plasma oscillations has been derived. We present the numerical simulation for this coupled system of equations, when the coupling arises through relativistic ponderomotive non-linearity. The filamentation of the laser beam has been found to vary appreciably with perturbation wave number. The results show that with time, localized structures become more complex and the plasma oscillation frequency spectra have several harmonic peaks at terahertz frequencies when the electron plasma frequency is in terahertz range and laser frequency is around 2.35 × 1015 rad/s. We also present the semi-analytical model to capture the underlying physics.
Leaving No One Behind: Participatory Technology Appraisal as a Platform for Agenda Setting to Address Disparities in Access to Health Services in Thailand
Authors: Tantivess Sripen , Doungthipsirikul Suradech 
Published: July 2019

AbstractObjectivesThis article discusses how participatory technology appraisal as part of the Universal Coverage Scheme (UCS) in Thailand contributes to improving access to essential health services among vulnerable populations.MethodsDocument review was conducted on health technology appraisal approaches introduced by the UCS. The review involves health benefit proposals advanced by stakeholders and also meeting minutes of relevant working groups and committees published between 2010 and 2015.ResultsFrom the establishment of the UCS participatory technology appraisal mechanism in 2010 until 2015, a total of 133 health interventions have been nominated. Some nominations highlight problems in access to care among vulnerable populations. As policy advocates continue to be involved in the latter stages of coverage decisions, they have opportunities to persuade policy makers and other stakeholders to agree to the rationales of their proposals. Some interventions were rejected because they did not meet value for money, affordability, and feasibility criteria; however, topic nominations from stakeholders as well as relevant deliberation throughout the technology appraisal processes have a potential to improve accessibility of health care among the disadvantaged.ConclusionsThrough participation in the UCS policy-making processes, key stakeholders are able to direct the attention of decision makers to significant gaps in access to services among vulnerable citizens, a health system problem rarely brought to discussion by policy elites and experts. The Thai experience reaffirms participatory technology appraisal as a supportive measure to providing universal health coverage.
New insights into the species diversity of Bartramia Hedw. (Bryophyta) in Antarctica
Authors: Câmara Paulo E.A.S. , Soares Abel E.R. , Henriques Diego Knop , Peralta Denilson Fernandes , Bordin Juçara , Carvalho-Silva Micheline , Stech Michael 
Published: July 2019

AbstractIn Antarctica, the genus Bartramia has been restricted to a single polymorphic species, B. patens. Its status as a separate species or a subspecies of the Northern Hemisphere B. ithyphylla was debated. In the present paper, we combine analyses of chloroplast (trnS–rps4–trnT–trnL–trnF region) and nuclear ITS sequences with a reinvestigation of morphological characteristics to infer the identity of Antarctic Bartramia. Phylogenetic and Automatic Barcode Gap Discovery (ABGD) species delimitation analyses indicate that the species diversity of Bartramia in Antarctica has been underestimated, since two species were identified, both belonging to Bartramia sect. Pyridium. Of these, B. subsymmetrica is a new record of the species for Antarctica, as it has previously only been recorded from Livingston Island, South Shetlands. The other species is B. patens, which is separated from B. ithyphylla by newly inferred morphological characteristics and is a sister species to the latter in the molecular phylogenetic analyses. Consequently, we consider B. ithyphylla to be a Northern Hemisphere instead of a bipolar species. The suggested conspecificity of both taxa into one species in the ABGD analysis is considered to result from overlumping by this species delimitation method. The delimitation of the three species of section Bartramia (B. halleriana, B. mossmaniana and B. pomiformis) and the circumscription of the genus Bartramia are discussed.
MARSWRF Prediction of Entry Descent Landing Profiles: Applications to Mars Exploration
Authors: Fonseca Ricardo Morais , Zorzano María‐Paz , Martín‐Torres Javier 
Published: July 2019

AbstractIn this paper we use the Mars implementation of the Planet Weather Research and Forecasting model, MarsWRF, to simulate the Entry, Descent and Landing (EDL) vertical profiles from six past missions: Pathfinder, Mars Exploration Rovers Opportunity and Spirit, Phoenix, Mars Science Laboratory Curiosity rover, and ExoMars 2016 (Schiaparelli), and compare the results with observed data. In order to investigate the sensitivity of the model predictions to the atmospheric dust distribution, MarsWRF is run with two prescribed dust scenarios. It is concluded that the MarsWRF EDL predictions can be used for guidance into the design and planning stage of future missions to the planet, as it generally captures the observed EDL profiles, although it has a tendency to underestimate the temperature and overestimate the density for heights above 15 km. This could be attributed to an incorrect representation of the observed dust loading. We have used the model to predict the EDL conditions that may be encountered by two future missions: ExoMars 2020 and Mars 2020. When run for Oxia Planum and Jezero Crater for the expected landing time, MarsWRF predicts a large sensitivity to the dust loading in particular for the horizontal wind speed above 10‐15 km with maximum differences of up to ±30 m/s for the former and ±15 m/s for the latter site. For both sites, the best time for EDL, that is, when the wind speed is generally the weakest with smaller shifts in direction, is predicted to be in the late morning and early afternoon.
ScintPi: A Low‐Cost, Easy‐to‐Build GPS Ionospheric Scintillation Monitor for DASI Studies of Space Weather, Education, and Citizen Science Initiatives
Authors: Rodrigues F. S. , Moraes A. O. 
Published: July 2019

AbstractWe report the proposal and results of a low‐cost, easy‐to‐build GPS‐based sensor for detection and monitoring ionospheric irregularities through the detection of amplitude scintillation. The system is based on the Raspberry Pi single‐board computer combined with an Adafruit Ultimate GPS peripheral, which is capable of measuring (at 10‐Hz rate) the intensity of the L1 signals transmitted by GPS satellites. We introduce and discuss results of short‐ and long‐term observations obtained with a prototype of this system deployed in Presidente Prudente, a low magnetic latitude site in Brazil. The deployment and observations were carried out to test the ability of the system to detect ionospheric scintillations and, therefore, monitor the occurrence of ionospheric irregularities associated with equatorial spread F. Our results show that this low‐cost sensor is indeed capable of detecting scintillation events associated with equatorial spread F. Comparison with simultaneous, collocated measurements made by a commercial scintillation monitor are also presented. The joint observations allowed us to quantify the performance of the low‐cost monitor and to identify sources of potential limitations. While the sensor cannot (and it was not intended to) substitute commercial scintillation monitors, the low cost allows its use in studies of ionospheric irregularities (space weather) that require observations made by distributed arrays of small instruments (DASI). Furthermore, the simplicity of the sensor design stimulates its use in educational and citizen science initiatives.
The Influence of Water on the Strength of Olivine Dislocation Slip Systems
Authors: Tielke Jacob , Mecklenburgh Julian , Mariani Elisabetta , Wheeler John 
Published: July 2019

AbstractThe nature of lattice‐preferred orientation (LPO) in olivine‐rich rocks strongly influences many important physical properties of Earth's upper mantle. Different LPO types have been observed to develop in deformation experiments on olivine‐rich rocks carried out at different water fugacity conditions. The development of the different LPO types has been attributed to dislocation slip systems in olivine having different sensitivities to water fugacity, but this hypothesis has not been directly tested. To measure the influence of water fugacity on the relative strengths of olivine dislocation slip systems, we carried out a series of deformation experiments on olivine single crystals under either anhydrous or hydrous conditions. The crystals were oriented to activate either the (010)[100], (001)[100], or (100)[001] dislocation slip systems using a direct shear geometry, which allows for isolation of single slip systems, in contrast to the multiple systems activated in experiments carried out in compression. Post‐deformation electron backscatter diffraction analyses reveal orientation gradients consistent with deformation occurring via the motion of dislocations on the activated slip systems. Crystals in all of the investigated orientations exhibit hydrolytic weakening, but crystals oriented to activate the (001)[100] slip system exhibit the largest degree of weakening. These results are consistent with a water‐induced change in LPO in olivine‐rich rocks deforming by dislocation creep. The rheological data obtained from the experiments can be used to improve models of LPO evolution in Earth's mantle, which is critical for imaging the structure of Earth's interior and predicting the movement of Earth's tectonic plates.
LINC81507 act as a competing endogenous RNA of miR-199b-5p to facilitate NSCLC proliferation and metastasis via regulating the CAV1/STAT3 pathway
Authors: Peng Wei , He Dan , Shan Bin , Wang Jun , Shi Wenwen , Zhao Wenyuan , Peng Zhenzi , Luo Qingxi , Duan Minghao , Li Bin , Cheng Yuanda , Dong Yeping , Tang Faqing , Zhang Chunfang , Duan Chaojun 
Published: July 2019

AbstractLung cancer is the leading cause of cancer-related mortality worldwide. Recently, accumulating data indicate that long noncoding RNAs (LncRNAs) function as novel crucial regulators of diverse biological processes, including proliferation and metastasis, in tumorigenesis. Lnc NONHSAT081507.1 (LINC81507) is associated with lung adenocarcinoma. However, its pathological role in non-small cell lung cancer (NSCLC) remains unknown. In our study we investigated the role of LINC81507 in NSCLC. The expression of LINC81507 was analyzed in 105 paired NSCLC tumor specimens and paired adjacent non-tumorous tissues from NSCLC patients by real-time quantitative PCR (RT-qPCR). Gain- and loss-of-function experiments were conducted to investigate the functions of LINC81507, miR-199b-5p and CAV1. Reduced expression of LINC81507 resulted in cell growth, proliferation, migration and epithelial–mesenchymal transition (EMT) in NSCLC cells, whereas ectopic overexpression of LINC81507 resulted in the opposite effects both in vitro and in vivo. Nuclear and Cytoplasmic fractionation assays showed LINC81507 mainly resided in cytoplasm. Bioinformatics analysis and dual-luciferase assays revealed that miR-199b-5p was a direct target of LINC81507 through binding Ago2. Mechanistic analysis demonstrated that miR-199b-5p specifically targeted the Caveolin1 (CAV1) gene, and LINC81507 inactivated the STAT3 pathway in a CAV1-dependent manner. Taken together, LINC81507 is decreased in NSCLC and functions as a sponge to miR-199b-5p to regulate CAV1/STAT3 pathway, which suggests that LINC81507 serve as a tumor suppressor and potential therapeutic target and biomarker for metastasis and prognosis in NSCLC.
C1q/tumor necrosis factor-related protein-3-engineered mesenchymal stromal cells attenuate cardiac impairment in mice with myocardial infarction
Authors: Zhang Zhengbin , Zhu Liwen , Feng Pan , Tan Yanzhen , Zhang Bing , Gao Erhe , Wang Xiaowu , Fan Chongxi , Wang Xiaoming , Yi Wei , Sun Yang 
Published: July 2019

AbstractMesenchymal stromal cells (MSCs) transplantation offers an attractive alternative in myocardial infarctive therapy. However, poor cell engraftment and survival limit their restorative capacity. C1q/tumor necrosis factor-related protein-3 (CTRP3) inhibits reverse remodeling after myocardial infarction (MI) and was found to be secreted by MSCs in our preliminary experiments. We examined whether the overexpression of CTRP3 improved the survival of transplanted MSCs and augmented their efficacy on MI and whether silencing CTRP3 attenuated these effects. For gain-of-function analysis, MSCs overexpressing CTRP3 (LvC3-MSCs), control virus-transfected MSCs (LvNull-MSCs), MSCs alone, or phosphate-buffered saline (PBS) were injected into the peripheral areas of the infarction immediately after coronary artery ligation. For loss-of-function analysis, mice subjected to MI were randomized into groups and administered CTRP3-knockdown MSCs (LvshC3-MSCs), Lvshctrl-MSCs, MSCs, or PBS. Survival rates, cardiac function, and myocardial remodeling in mice were evaluated after 4 weeks. Injection of MSCs or LvNull-MSCs improved the left ventricular ejection fraction, inhibited cardiac fibrosis, and regulated cellular profiles of the infarction border zone 4 weeks after MI compared with those in the PBS group. Furthermore, overexpression of hCTRP3 promoted the efficacy of MSCs in the treatment of MI. However, knocking down CTRP3 impaired that. Coculture experiments confirmed that hCTRP3-enriched conditioned medium (CM) promoted MSCs migration and protected against H2O2-induced cell damage. Conversely, CM from C3−/− MSCs (CTRP3 knock out) significantly reduced the migration and antioxidative effects of MSCs. CTRP3 protein alone promoted MSCs proliferation and migration by upregulating matrix metalloproteinase 9 (MMP9) and protecting against oxidation by increasing superoxide dismutase 2 (SOD2) and metallothionein 1/2 (MT1/2) expression; and these effects were blocked by pretreatment with the extracellular signal-regulated kinase (ERK1/2) inhibitor U0126. Overexpression of CTRP3 significantly improved the MSCs-based efficacy on MI by increasing cell survival and retention via a mechanism involving ERK1/2-MMP9 and ERK1/2-SOD2/MT1/2 signaling.
A novel mitochondrial micropeptide MPM enhances mitochondrial respiratory activity and promotes myogenic differentiation
Authors: Lin Yi-Fang , Xiao Man-Huan , Chen Hua-Xing , Meng Yu , Zhao Na , Yang Liang , Tang Haite , Wang Jia-Lei , Liu Xingguo , Zhu Ying , Zhuang Shi-Mei 
Published: July 2019

AbstractMicropeptides belong to a class of newly identified small molecules with <100 amino acids in length, and their functions remain largely unknown. Here, we identified a novel muscle-enriched micropeptide that was localized to mitochondria (named MPM, micropeptide in mitochondria) and upregulated during in vitro differentiation of C2C12 myoblasts and in vivo early postnatal skeletal muscle development, and muscle regeneration after cardiotoxin (CTX) damage. Downregulation of MPM was observed in the muscular tissues of tibial muscular dystrophy and Duchenne muscular dystrophy patients. Furthermore, MPM silencing inhibited the differentiation of C2C12 myoblasts into myotubes, whereas MPM overexpression stimulated it. MPM−/− mice exhibited smaller skeletal muscle fibers and worse muscle performance, such as decrease in the maximum grip force of limbs, the latency to fall off rotarod, and the exhausting swimming time. Muscle regeneration was also impaired in MPM−/− mice, as evidenced by lower expression of Pax7, MyoD, and MyoG after CTX injection and smaller regenerated myofibers, compared with wild-type mice. Mechanistical investigations based on both gain- and loss-of function studies revealed that MPM increased oxygen consumption and ATP production of mitochondria. Moreover, ectopic expression of PGC-1α, which can enhance mitochondrial respiration, attenuated the inhibitory effect of siMPM on myogenic differentiation. These results imply that MPM may promote myogenic differentiation and muscle fiber growth by enhancing mitochondrial respiratory activity, which highlights the importance of micropeptides in the elaborate regulatory network of both myogenesis and mitochondrial activity and implicates MPM as a potential target for muscular dystrophy therapy.