bluuebunny/crossref_metadata_2025_split huggingface dataset:
Procedural determinants of fluoroscopy time in patients undergoing cardiac catheterization
Authors: Mujtaba Syed Fayaz , Saghir Tahir , Sial Jawaid Akbar , Rizvi Nadeem Hassan 
Published: January 2019

Background & Objective: Due to increase in number of cardiac catheterization procedures safety concerns is an issue nowadays. Multiple diagnostic modalities use radiations, which also put a patient at higher cumulative radiation exposure. Therefore steps should be taken to minimize radiation exposure during cardiac catheterization. Hence determination of factors which prolong FT will result in better understanding of problem.This retrospective study was undertaken to determine factors responsible for prolong fluoroscopy time in patients undergoing coronary artery catheterization.
Methods: This retrospective study was conducted at catheterization Laboratory National Institute of Cardiovascular Diseases, Karachi from June 2014 to June 2015. Patients of either gender, aged between 18 to 90 years undergoing cardiac catheterization procedures were included. Radiation exposure time was measured in terms of fluoroscopy time.
Results: A total of 957 patients were included in this study out of which 731 were of diagnostic Coronary Angiograms (CA) and 226 were of Percutaneous Coronary Intervention (PCI). The mean age of the study participants was 54.12±10.89 years and majority 734(76.6%) were male. Mean fluoroscopy time (FT) in the patients subjected to PCI was 9.61±6.07 minutes while in cases for CA 4.17±4.13 minutes. FT for CA was observed significantly dependent on procedural access, operator’s experience, and LV angiogram. While FT for PCI was found dependent on number of stents deployed during the procedure.
Conclusion: For invasive coronary angiographic procedures radial route increased fluoroscopy time. For percutaneous coronary intervention femoral and radial route fluoroscopy time were not significantly different.
How to cite this:Mujtaba SF, Saghir T, Sial JA, Rizvi NH. Procedural determinants of fluoroscopy time in patients undergoing cardiac catheterization. Pak J Med Sci. 2019;35(1):166-171. doi: https://doi.org/10.12669/pjms.35.1.294
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Correlation between luteinizing hormone receptor gene expression in human granulosa cells with oocyte quality in poor responder patients undergoing in vitro fertilization: A cross-sectional study
Authors: Wiweko Budi , Satria M. Luky , Mutia Kresna , Iffanolida Pritta Ameilia , Harzif Achmad Kemal , Pratama Gita , Muharam R. , Hestiantoro Andon 
Published: January 2019

Background: This study was performed to evaluate the role of luteinizing hormone (LH) and granulosa cell LH receptor (LH-R) in poor responder patients who underwent controlled ovarian stimulation. Expression levels of LH-R mRNA in granulosa cells was investigated and compared with oocyte morphology, oocyte maturity and fertilization rate. Methods: Granulosa cells were obtained from 30 patients who underwent in vitro fertilization (IVF) at Dr. Cipto Mangunkusumo Hospital, Jakarta. The patients were divided into two groups: group I (n=10) poor responders; and group II (n=20) non-poor responders. After the extraction of total RNA from granulosa cells, semi-quantitative RT-PCR was performed and the amount of LH-R mRNA was quantified. The relative values were calculated as the ratio of LH-R mRNA and actin beta mRNA. Statistical analysis was performed using Mann-Whitney test and Spearman correlation. Results: The relative value of LH-R mRNA was higher in group I compared with group II (27.37[0.00-28939.37] vs 0.00[0.00-7196.12]). Oocyte maturity (r=0.267) and morphology (r=0.267) in group I consistently showed a positive correlation with LH-R mRNA; in group II a negative correlation with LH-R mRNA was shown for oocyte maturity (r= -0.552) and morphology (r= -0.164). Group I had a positive correlation between LH-R expression with fertilization rate (r=0.430), and group II showed a negative correlation (r=-0.340). Conclusions: The expression of LH-R mRNA has a positive correlation with oocyte quality in poor responder patients and a negative correlation in non-poor responders. Our study suggests an optimal expression of LH- R mRNA in granulosa cells during controlled ovarian stimulation to obtain good quality oocytes.
Feasibility of incorporating mindfulness based mental health promotion to the pregnancy care program in Sri Lanka: a pilot study
Authors: Agampodi Thilini , Katumuluwa Subhashini , Pattiyakumbura Thulani , Rankaduwa Nilupulee , Dissanayaka Thushari , Agampodi Suneth 
Published: January 2019

Background:Though widely discussed, mindfulness-based interventions (MBI) to improve maternal mental health is limited by lack of studies with system incorporation. We evaluate the feasibility of incorporating a MBI program into routine antenatal care (ANC) in Sri Lanka.Methods:MBI included learning mindfulness concepts, practicing mindfulness sitting/reclining meditation, performing mindful movements and practicing mindfulness in daily life. Feedback from the participants were obtained through an anonymous, self-administered, semi-structured questionnaire to determine the program’s cultural appropriateness, usefulness, and feasibility.Results:Participants reported that the training reduced the stress of their daily life, brought a sense of calmness to their mind and body, and improved their anger management. Participants felt strongly that this training would be very useful and a shortened version be included in the national ANC program.Conclusions:This pilot study suggests that an interventional study to evaluate system incorporation of a MBI to improve maternal mental health is feasible.
Animacy and Affectedness in Germanic Languages
Authors: Fleischhauer Jens 
Published: January 2019

Abstract
This paper deals with the influence of animacy on affectedness. German, like other Germanic languages, requires oblique marking of the inanimate undergoer argument of verbs of contact by impact (e.g. hit, kick, bite), whereas the animate undergoer argument takes non-oblique marking. Inanimacy does not necessarily result in oblique marking; undergoer arguments with inanimate referents are realized in a non-oblique construction if a change of state or location is explicitly predicated, as in resultative constructions. This suggests that the marking of inanimate undergoer arguments is conditioned by two factors: animacy and affectedness. The basic claim is that animate and inanimate entities are affected differently by hitting, kicking and similar activities. Inanimates can only be physically affected, whereas animates can be psychologically affected as well. Since verbs of contact by impact do not entail a change of state/location, they do not represent their undergoer arguments as being (necessarily) physically affected. Hence, the potential psychological effect of hitting, kicking and the like on animate beings gives rise for interpreting animate undergoer arguments of those verbs as being affected.
Deep intrinsically motivated continuous actor-critic for efficient robotic visuomotor skill learning
Authors: Hafez Muhammad Burhan , Weber Cornelius , Kerzel Matthias , Wermter Stefan 
Published: January 2019

Abstract
In this paper, we present a new intrinsically motivated actor-critic algorithm for learning continuous motor skills directly from raw visual input. Our neural architecture is composed of a critic and an actor network. Both networks receive the hidden representation of a deep convolutional autoencoder which is trained to reconstruct the visual input, while the centre-most hidden representation is also optimized to estimate the state value. Separately, an ensemble of predictive world models generates, based on its learning progress, an intrinsic reward signal which is combined with the extrinsic reward to guide the exploration of the actor-critic learner. Our approach is more data-efficient and inherently more stable than the existing actor-critic methods for continuous control from pixel data. We evaluate our algorithm for the task of learning robotic reaching and grasping skills on a realistic physics simulator and on a humanoid robot. The results show that the control policies learned with our approach can achieve better performance than the compared state-of-the-art and baseline algorithms in both dense-reward and challenging sparse-reward settings.
NMNAT Proteins that Limit Wallerian Degeneration Also Regulate Critical Period Plasticity in the Visual Cortex
Authors: van Lier Mariska , Smit-Rigter Laura , Krimpenfort Roos , Saiepour M. Hadi , Ruimschotel Emma , Kamphuis Willem , Heimel J. Alexander , Levelt Christiaan N. 
Published: January 2019

AbstractMany brain regions go through critical periods of development during which plasticity is enhanced. These critical periods are associated with extensive growth and retraction of thalamocortical and intracortical axons. Here, we investigated whether a signaling pathway that is central in Wallerian axon degeneration also regulates critical period plasticity in the primary visual cortex (V1). Wallerian degeneration is characterized by rapid disintegration of axons once they are separated from the cell body. This degenerative process is initiated by reduced presence of cytoplasmic nicotinamide mononucleotide adenylyltransferases (NMNATs) and is strongly delayed in mice overexpressing cytoplasmic NMNAT proteins, such as WldSmutant mice producing a UBE4b-NMNAT1 fusion protein or NMNAT3 transgenic mice. Here, we provide evidence that in WldSmice and NMNAT3 transgenic mice, ocular dominance (OD) plasticity in the developing visual cortex is reduced. This deficit is only observed during the second half of the critical period. Additionally, we detect an early increase of visual acuity in the V1 of WldSmice. We do not find evidence for Wallerian degeneration occurring during OD plasticity. Our findings suggest that NMNATs do not only regulate Wallerian degeneration during pathological conditions but also control cellular events that mediate critical period plasticity during the physiological development of the cortex.
Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting Protein That Modulates Excitatory Neurotransmission
Authors: Chander Praveen , Kennedy Matthew J. , Winckler Bettina , Weick Jason P. 
Published: January 2019

AbstractNeurons have evolved a number of unique protein-coding genes that regulate trafficking of protein complexes within small organelles throughout dendrites and axons. Neuron-specific gene 2 (NSG2) encodes for one of the most abundant proteins in the nervous system during perinatal development. NSG2 belongs to a family of small neuronal endosomal proteins but its function has remained uncharacterized to date. Here, we show that NSG2 is found in discrete punctae restricted to the somatodendritic arbors of developing mouse and human neurons, and a significant proportion of NSG2 punctae colocalize with postsynaptic HOMER1 and surface-expressed AMPA-type glutamate receptors (AMPARs) at excitatory synapses. Immunoprecipitation revealed that NSG2 physically interacts with both the GluA1 and GluA2 AMPAR subunits in mouse brain. Knock-out of NSG2 in mouse hippocampal neurons selectively impaired the frequency of miniature EPSCs (mEPSCs) and caused alterations in PSD95 expression at postsynaptic densities (PSDs). In contrast, NSG2 overexpression caused a significant increase in the amplitude of mEPSCs as well as GluA2 surface expression. Thus, NSG2 functions as an AMPAR-binding protein that is required for normal synapse formation and/or maintenance, and has unique functions compared with other NSG family members.
Penerapan Model Pembelajaran Shesil (Soft, Hard and Environment Skill Integrated Learning) pada Kecakapan Otomotif
Authors: Rakim Rakim , Wilonoyudho Saratri , Widjanarko Dwi 
Published: January 2019

Perkembangan teknologi dan informasi akan berdampak pada sendi sendi kehidupan manusia. Manusia membutuhkan kecakapan sesuai perkembangan jaman dan kemampuan untuk meminimalisasikan resiko akibat teknologi seperti pergeseran nilai karakter dan kerusakan lingkungan. Pendidikan menjadi garda terdepan dalam mewujudkan hal tersebut. Dibutuhkan pola pembelajaran yang menyeimbangkan pendidikan soft skill, hard skill dan environment skill dalam satu kesatuan. Penelitian ini yang dilakukan bertujuan untuk menghasilkan desain model pembelajaran SHESIL yaitu pembelajaran yang mengintegrasikan soft skill, hard skill dan environment skill dalam satu kesatuan. Berdasarkan uji validitas ahli, model pembelajaran SHESIL memiliki tingkat kevalidan yang baik dan layak digunakan. Efektifitas model dapat dilihat pada uji coba lapangan. Hasil data lapangan menunjukan ada peningkatan pada penilaian soft skill, hard skill dan environment skill. Penilaian keseluruhan aspek dari soft skill, hard skill dan environment skill terhadap peningkatan kecakapan otomotif menunjukan ( t hitung 10,58 > t tabel - 1,64) sehingga disimpulkan model pembelajaran SHESIL efektif meningkatkan kecakapan otomotif siswa SMK. Penerapan model pembelajaran SHESIL menjadi alternatif pilihan dalam membantu guru untuk menanamkan pendidikan soft skill dan kesadaran lingkungan sesuai tujuan pendidikan nasional. The development of technology and information will affect to the principal of human life. Humans need skills based on the development of time and ability to minimize risks caused by technology such as shifting character values and environmental damage. Education becomes foremost guard in creating it. We need learning model which balances soft skill, hard skill and environment skill in a single entity. The purpose of this research is to produce SHESIL learning model that is the application of learning to integrate soft skill, hard skill and environment skill in one unit. Based on validity test done by the expert, SHESIL learning model has a feasible and fair validity to be used. The effectiveness of the model can be on field experiment. The result of field data showed that there was a soft skill improvement, environmental skill improvement and t count 31,46 and hard skill improvement. The whole assessment of soft skill, hard skill and environment skill to the improvement of automotive skill showed t count bigger than t table (10,58> - 1,64) so we can that conclude that SHESIL learning model can improve the automotive skill of vocational students effectively. Application of SHESIL learning model is becomes an alternative choice to assist teachers in realizing soft skill education and environmental sensitivity matching to goals of national education.
The Analysis of Vocational Teacher Readiness at Culinary Education Program in Participating in Online Professional Teacher Education Program
Authors: Saramoya Siva , Basyirun Basyirun , Murdani Murdani 
Published: January 2019

This study aims to: (1) describe the readiness of vocational school teacher of culinary program in the implementation of online - based Professional Teacher Education (PTE); (2) find factors driving and inhibiting the readiness of teachers in the implementation of online – based PTE. This quantitative descriptive study was conducted at SMK N 6 Semarang (Tourism Vocational School) and SMK N 1 Bawen (Agricultural Vocational School) involving 14 productive skill teachers of the Culinary Program. The data were obtained using questionnaires and analyzed descriptively using percentages. The results of the study were: 57% of teachers had very high readiness, 36% were high and only 7% had sufficient readiness. The factors supporting the readiness of productive teacher skill at culinary program during the implementation of online – based PTE are facilities and infrastructure (79%), Knowledge on the field of culinary program (86%), pedagogical competence (79%), personal competence (86%), social competence (86%) and professional competence (93%). Factors inhibiting the readiness of the online – based PPG is the computer literacy (57%) and networking access (64%). It was concluded that teachers have a high readiness in the implementation of online – based PTE. Factors supporting the readiness of the online PTE are infrastructure, the knowledge, pedagogical competence, personal competence, social and professional competence. The inhibiting factor is the ability to operate a computer and access the network.
Contribution of Understanding Design Principles and Control of Design Media Use on Aesthetic Quality Design Students of Fashion Vocational School in Kudus
Authors: Puspita Rahma Aditia , Wahyuningsih Sri Endah , Syamwil Rodia 
Published: January 2019

Understanding the basic material of design and mastery of the media if it is technically adequate, it can be ascertained that the design of the clothes produced by students looks more aesthetic. The purpose of research: (1) determine the contribution of understanding of the design principles of the aesthetic quality fashion design, (2) determine contributions mastery media use design to the aesthetic quality of fashion design, (3) determine contributions jointly between the understanding of design principles and mastering the use of design media for the aesthetic quality of fashion designs made by fashion students of Vocational School in Kudus. The pattern used in this study is correlation with a quantitative approach. The studies population is 76 second grade student of dressmaking study program of SMK N 1 Kudus. The research sample is 38 students inclass XI TB 1 SMK N 1 Kudus. In this study there are 2 independent variables namely Understanding the Principles of Designand Mastery of Use of Media Design. Meanwhile the dependent variable is Aesthetic Quality Design. In doing validation, there are 2 ways, namely: (1) Expert Validation (2) Trial Validation. Reliabilitas items made by using Alpha formula. The data analysis technique uses the correlation analysis formula. Reliability performen this study using a test of consistency cohen's kappa. There contributed between 1st assessors and 2nd assessors on the aesthetic quality of design with koefiseincohen's kappa value of 0.200 which means there is no agreement among 1st assessors and 2ndassessors in assessing the aesthetic quality fashion design. The results showed that based on calculations π x1y.x = 0,296, dan ρ = 0,040 ˂ 0,05 which indicates that it is significant, supported by data (accepted). The values obtained show an understanding of design principlescontributing positively to the aesthetic quality of fashion designs.Based on calculations π x2y.x1 = 0,808, ρ = 0,00 ˂ 0,05 which indicates that it is significant, supported by data (accepted). The value obtained shows mastery of the use of design media contributes positively to the aesthetic quality of fashion designs. Based on the calculation of the correlation test in the third hypothesis, R = 0.989, with Fcount = 732,482, and ρ = 0,00 ˂ 0,05, thus the correlation coefficient is positive, the relationship is in the same direction between the two variables. That is, there is a positive relationship between understanding the principles of design and the use of media with the aesthetic quality of fashion designs. After comparing it with a table, it is concluded that it has a very high correlation. This implies that the influence of the independent variable (X) on the dependent variable (Y) is 97,8 %, the rest is influenced by other variables.
When Differing Perspectives Between Health Care Providers and Parents Lead to “Communication Crises”: A Conceptual Framework to Support Prevention and Navigation in the Pediatric Hospital Setting
Authors: Barnard Chantelle , Sandhu Amonpreet , Cooke Suzette 
Published: January 2019

OBJECTIVES:
The communication experience and therapeutic relationships between parents and health care providers (HCPs) impacts the quality of patient care. A guiding “communication crisis” description was created to encourage study participants to describe difficult communication encounters between parents and HCPs where their perspectives regarding the recommended patient care conflicted (ie, parent refusal of a lumbar puncture), which created barriers to the provision of optimal care and the development of therapeutic relationships in the pediatric hospital setting. The purpose of this research was to highlight factors that may contribute to communication crises through the characterization of these circumstances.

METHODS:
Participants were multidisciplinary HCPs and parents (n = 37) with firsthand experience regarding communication crises. Data were collected through focus groups (7), semistructured interviews (2), and a verification focus group where open-ended questions regarding participants’ experiences were used. Data were analyzed by using a constructivist grounded theory approach.

RESULTS:
Three themes and 11 subthemes (communication crisis risk factors) were identified: (1) health care team factors (communication skills, care processes, and interprofessional communication), (2) family and/or parent factors (language or cultural barriers, mental health conditions, socioeconomic factors, and beliefs), (3) patient factors (acute condition, unclear diagnosis, unstable condition, and medical complexity). A core theory emerged: parent trust in their HCP significantly impacts the therapeutic relationship and can mitigate communication crises despite the presence of risk factors.

CONCLUSIONS:
We highlight factors that may be predisposing to communication crises in pediatric hospital settings. Awareness of these factors can support timely identification and implementation of relationship care and foster the establishment of trusting relationships.
The Incidence and Nature of Allergic and Anaphylactic Reactions During Pediatric Procedural Sedation: A Report From the Pediatric Sedation Research Consortium
Authors: Hertzog James H. , Preisberga Krista , Penfil Scott 
Published: January 2019

BACKGROUND AND OBJECTIVES:
Anaphylaxis is rare but life-threatening. Its incidence during pediatric procedural sedation outside of the operating room is unknown. We used data from the Pediatric Sedation Research Consortium (PSRC) to determine the incidence and nature of allergic and anaphylactic reactions in this practice.

METHODS:
A retrospective observational study of prospectively collected information in the PSRC’s multicenter database was performed. Cases of allergic reaction were identified. Because anaphylaxis is not a listed complication in the PSRC database, all cases for which allergic reaction was noted were reviewed for the occurrence of other complications or interventions that would suggest at least 2 organ system derangements consistent with anaphylaxis as well as for practitioner commentary stating the occurrence of anaphylaxis. Descriptive analyses of demographic information and summary statistics were performed, and multiple logistic regression analysis was used to evaluate associations between the occurrence of allergic reactions and medications.

RESULTS:
During the study period, 227 833 cases were entered into the PSRC database. There were 54 cases of allergic reaction (incidence 1:4219); 6 were consistent with anaphylaxis (incidence 1:37 972). A significant association between the development of allergic reaction and 4 sedative and/or analgesic medications was noted: midazolam (odds ratio [OR] 2.2; confidence interval [CI] 1.2–3.9), ketamine (OR 3.8; CI 2.1–7.1), methohexital (OR 48.8; CI 14.9–159.9), and morphine (OR 4.4; CI 1.04–18.2). There were no mortalities.

CONCLUSIONS:
Allergic reactions and anaphylaxis during pediatric procedural sedation are rare. In this study, the development of allergic reactions was significantly associated with the use of midazolam, ketamine, methohexital, and morphine.