bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stakeholders’ perspectives on disinvestment of low-value healthcare interventions and practices in Malaysia: an online survey
Authors: Kamaruzaman Hanin Farhana , Grieve Eleanor , Ku Abd Rahim Ku Nurhasni , Izzuna MMG , Sit Wai Lee , Romli Erni Zurina , Abdullah Mohamed Hirman , Wu Olivia 
Published: November 2024

Abstract

Objectives
Healthcare disinvestment requires multi-level decision-making, and early stakeholder engagement is essential to facilitate implementation and acceptance. This study aimed to explore the perceptions of Malaysian healthcare stakeholders to disinvestment initiatives as well as identify disinvestment activities in the country.

Methods
A cross-sectional online survey was conducted from February to March 2023 among Malaysian healthcare stakeholders involved in resource allocation and decision-making at various levels of governance. Response frequencies were analyzed descriptively and cross-tabulation was performed for specific questions to compare the responses of different groups of stakeholders. For free-text replies, content analysis was used with each verbatim response examined and assigned a theme.

Results
A total of 153 complete responses were analyzed and approximately 37 percent of participants had prior involvement in disinvestment initiatives. Clinical effectiveness and cost-effectiveness ranked as the most important criteria in assessment for disinvestment. Surprisingly, equity was rated the lowest priority despite its crucial role in healthcare decision-making. Almost 90 percent of the respondents concurred that a formal disinvestment framework is necessary and the importance of training for the program’s successful implementation. Key obstacles to the adoption of disinvestment include insufficient stakeholder support and political will as well as a lack of expertise in executing the process.

Conclusions
While disinvestment is perceived as a priority for efficient resource allocation in Malaysian healthcare, there is a lack of a systematic framework for its implementation. Future research should prioritize methodological analysis in healthcare disinvestment and strategies for integrating equity considerations in evaluating disinvestment candidates.
Relaxation States of Large Impact Basins on Mercury Based on MESSENGER Data
Authors: Szczech Claudia , Broquet Adrien , Plesa Ana‐Catalina , Fleury Aymeric , Walterová Michaela , Stark Alexander , Oberst Jürgen 
Published: November 2024

AbstractThe crustal structure of Mercury's large impact basins provides valuable insights into the planet's geological history. For a warm crust, a post‐impact basin structure will viscously relax with inward flow of crustal materials toward the basin center. This effect drastically diminishes the crustal thickness contrasts and associated Bouguer gravity contrasts between the basin center and its surroundings. Here, we analyze Bouguer contrasts of 36 basins (diameter 300 km) located in the northern hemisphere as a proxy for viscoelastic relaxation. Thermal evolution models, assuming the present 3:2 spin‐orbit configuration, are used to predict crustal temperatures. Our analysis reveals that the expected correlation between zones of warm crust and low Bouguer contrast from relaxation is not observed in the available data. This suggests that crustal temperatures have changed in the past, potentially due to a change in Mercury's orbit or to a major volcanic event associated with smooth plain formation.
Shallow Lake, Strong Shake: Record of Seismically Triggered Lacustrine Sedimentation From the 1959 M7.3 Hebgen Lake Earthquake Within Henrys Lake, Idaho
Authors: Nicovich Sylvia R. , DuRoss Christopher B. , Thompson Jobe Jessica A. , Rodysill Jessica R. , Briggs Richard W. , Hatem Alexandra E. , Tan Madeleine M. , Gavillot Yann , Lindberg Noah S. , Strickland Laura E. , Padgett Jason S. 
Published: November 2024

AbstractWe investigate a shallow lake basin for evidence of a large historic intraplate earthquake in western North America. Henrys Lake, Idaho is an atypical candidate for lacustrine paleoseismic study given its shallow depth (∼7 m) and low relief (≤2° slopes). Here, we test the earthquake‐recording capacity of this basin type by showing sedimentological evidence of the 1959 M7.3 Hebgen Lake earthquake within sediment cores, using anthropogenically produced 137Cs activity to constrain timing. In addition to expanding the morphologic range of basins targeted for lacustrine paleoseismic studies, this work has implications for sediment response in dam‐enhanced basins. Lack of sedimentological evidence for other earthquakes coupled with radiocarbon chronology reveals that the 1959 event is the only clearly recorded earthquake within Henrys Lake since the mid‐Holocene. Henrys Lake offers a proxy for paleo‐earthquake signatures within similar lacustrine environments and underscores the importance of further paleoseismic studies in the region.
Interdecadal Variations in the Spatial Pattern of the Arctic Oscillation Arctic Center in Wintertime
Authors: Fang Zhou , Sun Xuguang , Yang Xiu‐Qun , Zhu Zhiwei 
Published: November 2024

AbstractArctic Oscillation (AO) is the dominant mode of atmospheric circulation in the extratropical Northern Hemisphere regions. The spatial pattern of the AO Arctic center affects the extent of polar cold air outbreaks southward. However, the underlying nature and causes of its interdecadal variation remain unclear. Utilizing ERA5 reanalysis data, this study identifies two distinct spatial patterns of the wintertime AO Arctic center through the K‐means clustering method, which alternate over different decade periods. The Double‐trough pattern generates a tripolar temperature pattern of “cold Arctic‐warm Eurasia‐cold Tibetan Plateau” through a Rossby wave train during 1960–1997/2013–2024. While the Single‐trough pattern leads to a dipolar temperature pattern in 1998–2012. Furthermore, interdecadal variations in North Atlantic sea surface temperature meridional gradient act as an influencing factor in shaping the spatial pattern of the AO Arctic center. This research aids the understanding and prediction of climate anomalies using AO signals within various decadal contexts.
Rapid Coalescence of Bubbles Driven by Buoyancy Force: Implication for Slug Formation in Basaltic Eruptions
Authors: Maruishi Takafumi , Toramaru Atsushi 
Published: November 2024

AbstractIn basaltic eruptions, bubbles move freely and collide within a volcanic conduit, leading to frequent bubble coalescence. Understanding the dynamics of buoyancy‐driven coalescence of bubbles is crucial for predicting the explosivity of basaltic eruptions. We examine the evolution of the bubble volume distribution while considering buoyancy‐driven coalescence and expansion due to decompression. We find that, at lower decompression rates, the bubble volume distribution rapidly evolves into a power‐law distribution with an exponent of approximately as . This suggests that, in basaltic magma, the repeated coalescence of bubbles rapidly forms large bubbles within 45 min to 3 days. We then examine the occurrence of eruption styles, specifically Strombolian or Hawaiian, under the assumption that the bursts of slugs, produced from bubble coalescence within the conduit, trigger Strombolian eruptions. Consequently, we identify a critical condition for the transition between eruption styles in terms of the ascent velocity of magma. This critical ascent velocity is consistent with the observed transitions between Strombolian and Hawaiian eruptions at Izu‐Oshima and Kilauea.
SPIN1 accelerates tumorigenesis and confers radioresistance in non-small cell lung cancer by orchestrating the FOXO3a/FOXM1 axis
Authors: Zhong Min , Fang Zhi , Zou Juntao , Chen Xiao , Qiu Zezhi , Zhou Ling , Le Yi , Chen Zhen , Liao Yanyu , Nie Fengting , Wei Xianpin , Zhan Jinbo , Xiong Jianping , Xiang Xiaojun , Fang Ziling 
Published: November 2024

AbstractDespite the importance of radiation therapy as a nonsurgical treatment for non-small cell lung cancer (NSCLC), radiation resistance has always been a concern because of poor patient response and outcomes. Therefore, it is crucial to identify novel targets to increase the effectiveness of radiotherapy and investigate the mechanisms underlying radioresistance. Previously, we demonstrated that Spindlin 1 (SPIN1) was related to tumour initiation and progression. In this study, we found that SPIN1 expression was higher in NSCLC tissues and cell lines than in the corresponding controls. SPIN1 overexpression in NSCLC patients was closely correlated with disease progression and poor prognosis. Functionally, SPIN1 depletion inhibited cell proliferation, decreased the percentage of cells in the G2/M phase and suppressed cell migration and invasion. Moreover, SPIN1 knockdown decreased the clonogenic capacity, impaired double-strand break (DSB) repair and increased NSCLC radiosensitivity. Mechanistically, forkhead box M1 (FOXM1) was identified as a key downstream effector of SPIN1 in NSCLC cells. Furthermore, SPIN1 was found to facilitate MDM2-mediated FOXO3a ubiquitination and degradation, leading to FOXM1 upregulation. Moreover, restoration of FOXM1 expression markedly abolished the inhibitory effects and increased radiosensitivity induced by SPIN1 depletion. These results indicate that the SPIN1-MDM2-FOXO3a/FOXM1 signalling axis is essential for NSCLC progression and radioresistance and could serve as a therapeutic target for increasing radiotherapy efficacy.
Estimating the optimal age for infant measles vaccination
Authors: Goult Elizabeth , Barrero Guevara Laura Andrea , Briga Michael , Domenech de Cellès Matthieu 
Published: November 2024

AbstractThe persistence of measles in many countries demonstrates large immunity gaps, resulting from incomplete or ineffective immunization with measles-containing vaccines (MCVs). MCV impact is determined, in part, by vaccination age. Infants who receive dose 1 (MCV1) at older ages have a reduced risk of vaccine failure, but also an increased risk of contracting infection before vaccination. Here, we designed a new method—based on a mathematical transmission model incorporating realistic vaccination delays and age variations in MCV1 effectiveness—to capture the MCV1 age risk trade-off and estimate the optimal age for recommending MCV1. We applied this method to a range of synthetic populations representing lower- and higher-income populations. We predict a large heterogeneity in the optimal MCV1 ages (range: 6–20 months), contrasting the homogeneity of observed recommendations worldwide. Furthermore, we show that the optimal age depends on the local epidemiology of measles, with a lower optimal age predicted in populations having lower vaccination coverage or suffering higher transmission. Overall, our results suggest the scope for public health authorities to tailor the recommended schedule for better measles control.
Interface engineering enabling thin lithium metal electrodes down to 0.78 μm for garnet-type solid-state batteries
Authors: Ji Weijie , Luo Bi , Wang Qi , Yu Guihui , Zhang Zixun , Tian Yi , Zhao Zaowen , Zhao Ruirui , Wang Shubin , Wang Xiaowei , Zhang Bao , Zhang Jiafeng , Sang Zhiyuan , Liang Ji 
Published: November 2024

AbstractControllable engineering of thin lithium (Li) metal is essential for increasing the energy density of solid-state batteries and clarifying the interfacial evolution mechanisms of a lithium metal negative electrode. However, fabricating a thin lithium electrode faces significant challenges due to the fragility and high viscosity of Li metal. Herein, through facile treatment of Ta-doped Li7La3Zr2O12 (LLZTO) with trifluoromethanesulfonic acid, its surface Li2CO3 species is converted into a lithiophilic layer with LiCF3SO3 and LiF components. It enables the thickness control of Li metal negative electrodes, ranging from 0.78 μm to 30 μm. Quasi-solid-state lithium-metal battery with an optimized 7.54 μm-thick lithium metal negative electrode, a commercial LiNi0.83Co0.11Mn0.06O2 positive electrode, and a negative/positive electrode capacity ratio of 1.1 shows a 500 cycles lifespan with a final discharge specific capacity of 99 mAh g−1 at 2.35 mA cm−2 and 25 °C. Through multi-scale characterizations of the thin lithium negative electrode, we clarify the multi-dimensional compositional evolution and failure mechanisms of lithium-deficient and -rich regions (0.78 μm and 7.54 μm), on its surface, inside it, or at the Li/LLZTO interface.
Heart regeneration from the whole-organism perspective to single-cell resolution
Authors: Chen Xiaoxin , Zhong Xiaochen , Huang Guo N. 
Published: November 2024

AbstractCardiac regenerative potential in the animal kingdom displays striking divergence across ontogeny and phylogeny. Here we discuss several fundamental questions in heart regeneration and provide both a holistic view of heart regeneration in the organism as a whole, as well as a single-cell perspective on intercellular communication among diverse cardiac cell populations. We hope to provide valuable insights that advance our understanding of organ regeneration and future therapeutic strategies.
Lunar farside volcanism 2.8 billion years ago from Chang’e-6 basalts
Authors: Zhang Qian W. L. , Yang Mu-Han , Li Qiu-Li , Liu Yu , Yue Zong-Yu , Zhou Qin , Chen Liu-Yang , Ma Hong-Xia , Yang Sai-Hong , Tang Xu , Zhang Guang-Liang , Ren Xin , Li Xian-Hua 
Published: November 2024

Abstract
Unravelling the volcanic history of the enigmatic lunar farside is essential for understanding the hemispheric dichotomy of the Moon1–3. Cratering chronology established for the lunar nearside has been used to suggest long-lived volcanism on the farside of the Moon3,4 but without sample verification. We describe two episodes of basaltic volcanism identified by Pb–Pb dating of basalt fragments returned by the Chang’e-6 mission. One high-Al basalt fragment, dated at 4,203 ± 4 million years ago (Ma), has a source 238U/204Pb ratio (µ value) of approximately 1,620, implying a KREEP-rich (K, rare earth elements and P) source for this oldest-known example of basaltic volcanism among returned samples. The main volcanic episode of the Chang’e-6 basalt documents a surprisingly young eruption age of 2,807 ± 3 Ma, which has not been observed on the nearside of the Moon. The initial Pb isotope compositions of these younger basalts indicate a derivation from a source with a µ value of approximately 360, indicating a KREEP-poor mantle source. Mare volcanism on the lunar farside thus persisted for over 1.4 billion years, even if the source was depleted in heat-producing elements. The consistency between the 2.8-billion-year basalt age and the crater-counting age indicates that the cratering chronology model established for the lunar nearside is also applicable to the farside of the Moon.
Mid-career pitfall of consecutive success in science
Authors: Higashide Noriyuki , Miura Takahiro , Tomokiyo Yuta , Asatani Kimitaka , Sakata Ichiro 
Published: November 2024

AbstractThe creativity of scientists often manifests as localized hot streaks of significant success. Understanding the underlying mechanisms of these influential phases can enhance the effectiveness of support systems and funding allocation, fostering groundbreaking discoveries worthy of accolades. Historically, analyses have suggested that hot streaks occur randomly over time. However, our research, through meticulous examination, reveals that these phases are not flatly distributed but are more frequent at the early and late stages of scientists’ careers. Notably, both early and late hot streaks are marked by dense tie collaborations, with the former typically involving close partnerships with particular authors and the latter being characterized by involvement in large-scale projects compared with single-top or ordinary papers. This pattern indicates that mid-career researchers lack both intimate relations and resources to keep big projects, leading to “mid-career pitfall” of consecutive success. This insight holds profound implications for the development of policies and initiatives aimed at bolstering innovative research and discovery.
Genetic connectivity of wolverines in western North America
Authors: Day Casey C. , Landguth Erin L. , Sawaya Michael A. , Clevenger Anthony P , Long Robert A. , Holden Zachary A. , Akins Jocelyn R. , Anderson Robert B. , Aubry Keith B. , Barrueto Mirjam , Bjornlie Nichole L. , Copeland Jeffrey P. , Fisher Jason T. , Forshner Anne , Gude Justin A. , Hausleitner Doris , Heim Nichole A. , Heinemeyer Kimberly S. , Hubbs Anne , Inman Robert M. , Jackson Scott , Jokinen Michael , Kluge Nathan P. , Kortello Andrea , Lacroix Deborah L. , Lamar Luke , Larson Lisa I. , Lewis Jeffrey C. , Lockman Dave , Lucid Michael K. , MacKay Paula , Magoun Audrey J. , McLellan Michelle L. , Moriarty Katie M. , Mosby Cory E. , Mowat Garth , Nietvelt Clifford G. , Paetkau David , Palm Eric C. , Paul Kylie J.S. , Pilgrim Kristine L. , Raley Catherine M. , Schwartz Michael K. , Scrafford Matthew A. , Squires John R. , Walker Zachary J. , Waller John S. , Weir Richard D. , Zeller Katherine A. 
Published: November 2024

AbstractWolverine distribution contracted along the southern periphery of its range in North America during the 19th and 20th centuries due primarily to human influences. This history, along with low densities, sensitivity to climate change, and concerns about connectivity among fragmented habitats spurred the recent US federal listing of threatened status and special concern status in Canada. To help inform large scale landscape connectivity, we collected 882 genetic samples genotyped at 19 microsatellite loci. We employed multiple statistical models to assess the landscape factors (terrain complexity, human disturbance, forest configuration, and climate) associated with wolverine genetic connectivity across 2.2 million km2 of southwestern Canada and the northwestern contiguous United States. Genetic similarity (positive spatial autocorrelation) of wolverines was detected up to 555 km and a high-to-low gradient of genetic diversity occurred from north-to-south. Landscape genetics analyses confirmed that wolverine genetic connectivity has been negatively influenced by human disturbance at broad scales and positively influenced by forest cover and snow persistence at fine- and broad–scales, respectively. This information applied across large landscapes can be used to guide management actions with the goal of maintaining or restoring population connectivity.
Industrial hemp biomass negatively affected by herbicide drift from corn and soybean herbicides
Authors: Zaric Milos , Canella Vieira Bruno , Houston Barbara , Sousa Alves Guilherme , Wortman Sam E. , Peterson Julie , Kruger Greg R. 
Published: November 2024

AbstractThe establishment of industrial hemp (Cannabis sativa L.) fields near row crops has raised concerns about the potential adverse effects of herbicide drift on hemp production. This study examined hemp susceptibility to drift of herbicides registered for use in corn and/or soybeans. Herbicide solutions (2,4-D, dicamba, glufosinate, glyphosate, imazethapyr, lactofen, mesotrione) were applied separately in the wind tunnel (3.6 m s−1 airspeed), simulating drift scenarios, with conventional TP95015EVS (TP) and air inclusion AI95015EVS (AI) flat fan nozzles calibrated to deliver 140 L ha−1 carrier volume at 230 kPa. Mylar cards and hemp plants (20–25 cm tall) were placed downwind up to 12 m. Spray deposition from mylar cards was quantified using fluorometry and hemp biomass was collected 21 post application. Results indicated the nozzle design influenced downwind deposition; 5% of spray deposits from the TP nozzle reached 5.9 m downwind versus 2.0 m for the AI nozzle. Glyphosate, glufosinate, and mesotrione caused the highest biomass reductions, with 50% reductions observed at 19.3 (inferred), 8.7, and 9.3 m downwind for TP nozzle, and 4.1, 4.0, and 2.9 m for AI nozzle. These findings suggest herbicide applications at airspeeds of 3.6 m s−1 or greater present a risk to nearby hemp fields.
The discovery of an overseen pygmy backswimmer in Europe (Heteroptera, Nepomorpha, Pleidae)
Authors: Raupach Michael J. , Charzinski Nele , Villastrigo Adrian , Gossner Martin M. , Niedringhaus Rolf , Schäfer Peter , Schmelzle Sebastian , Strauß Gerhard , Hendrich Lars 
Published: November 2024

AbstractThe Pleidae, or pygmy backswimmers, is a family of aquatic bugs (Hemiptera, Heteroptera, Nepomorpha) containing four genera. Here, we describe Plea cryptica sp. nov. and redescribe its sister species, Plea minutissima Leach, 1817. Whereas the morphological distinction of these closely related species is only possible for males, molecular data clearly separate them. As part of our taxonomic study, we provide comprehensive molecular data including more than 200 DNA barcodes from all over Europe, complete nuclear ribosomal DNA, full mitochondrial genome data, and 3D scans for both species. Furthermore, the same molecular markers are also presented for Neoplea striola (Fieber, 1844). We used Maximum Likelihood (ML) analyses to reconstruct the phylogeny of the Pleidae and Notonectoidea based on available mitogenomic data. Our study represents a successful implementation of the proposed concept of taxonomics, using data from high-throughput sequencing technologies for integrative taxonomic studies, and allowing high confidence for both biodiversity and ecological research.
Alterations in center-surround contrast suppression in patients with major depressive disorder
Authors: Nickel Kathrin , Heinrich Sven P. , Beringer Malina , Endres Dominique , Runge Kimon , Küchlin Sebastian , Maier Simon , Bach Michael , Domschke Katharina , Tebartz van Elst Ludger , Friedel Evelyn B. N. 
Published: November 2024

AbstractPrevious pattern electroretinogram studies indicate reduced retinal contrast gain in patients with a major depressive disorder (MDD) which may contribute to alterations in visual perception. In line, psychophysical investigations reported elevated contrast thresholds in MDD. This study aims to gain insights into higher-level processing of visual information in MDD by evaluating contrast suppression. We examined contrast suppression of 21 MDD patients and 23 healthy controls (HC) using four different stimulus conditions (spatial frequencies 6.3 and 12.6 cpd at 30% and 60% background contrast) in a psychophysical test. Participants were instructed to adjust perceived contrasts between two vertical target patches, embedded in a horizontally or vertically oriented grid background. With finer stimulus gratings, MDD patients exhibited less contrast suppression compared to HC, particularly when the stimulus contrast was high (p = 0.006; MDD vs. HC =  − 45%). Contrast suppression in the HC group was significantly reduced for the coarse compared to the fine grating, while contrast suppression scores in MDD did not change with the spatial properties of the stimulus. The reduced contrast suppression in patients with MDD supports the hypothesis of altered dopaminergic neurotransmission and could be attributed to alterations in the retinal receptive fields or in dysfunctional adaptation mechanisms in depression.