bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clozapine-resistant schizophrenia – non pharmacological augmentation methods
Authors: Gałaszkiewicz Joanna , Rębisz Krzysztof , Morylowska-Topolska Justyna , Karakuła-Juchnowicz Hanna , Kozak Gustaw 
Published: April 2018

Abstract
Clozapine is the drug of choice for drug-resistant schizophrenia, but despite its use, 30-40% patients fail to achieve satisfactory therapeutic effects. In such situations, augmentation attempts are made by both pharmacological and non-pharmacological methods. To date, most of the work has been devoted to pharmacological strategies, much less to augemantation of clozapine with electroconvulsive therapy (C+ECT), transcranial direct current stimulation (tDCS) or transcranial magnetic stimulation (TMS).
Aim: The aim of the work is to present biological, non-pharmacological augmentation treatment methods with clozapine.
Material and methods: A review of the literature on non-pharmacological augmentation treatment methods with clozapine was made. PubMed database was searched using key words: drug-resistant schizophrenia, clozapine, ECT, transcranial magnetic stimulation, transcranial electrical stimulation and time descriptors: 1980-2017.
Results: Most studies on the possibility of increasing the efficacy of clozapine was devoted to combination therapy with clozapine + electric treatments. They have shown improved efficacy when using these two methods simultaneously from 37.5 to 100%. The only randomized trial so far has also confirmed the effectiveness of this procedure. Despite the described side effects of tachycardia or prolonged seizures, most studies indicate the safety and efficacy of combined use of clozapine and electroconvulsive therapy. Transcranial magnetic stimulation also appears to be a safe method in patients treated with clozapine. However, further research is needed before ECT can be included in standard TRS treatment algorithms. The data for combining transcranial electrical stimulation with clozapine, come only from descriptions of cases and need to be confirmed in controlled studies.
Conclusions: The results of studies on the possibility of increasing the effectiveness of clozapine using biological non-pharmacological treatment methods indicate a potentially beneficial effect of this type of methods in breaking the super-resistance in schizophrenia. Combination of clozapine and ECT can be considered as the most recommended strategy among these treatment methods.
The role of oxytocin in the pathogenesis and treatment of schizophrenia
Authors: Jusiak Katarzyna , Brudkowska Żaneta , Gołębiowska Maria , Morylowska-Topolska Justyna , Gołębiowska Beata , Próchnicki Michał , Próchnicka Agnieszka , Karakuła-Juchnowicz Hanna 
Published: April 2018

Abstract
Introduction: Until recently, oxytocin was mainly associated with the pathophysiology of childbirth and sexual functions, but lately this hormone has become the object of interest to psychiatry and psychology due to the significant influence of oxytocin on human behavior in the field of social and emotional functioning. Current scientific research focuses on the participation of oxytocin in the pathogenesis and therapy of mental disorders.
Aim: The aim of the paper is to present, on the basis of available literature, the significance of oxytocin for various psychological functions, with particular emphasis on the influence of oxytocin on the course and clinical picture of schizophrenia.
Method: Available articles from the Medline / PubMed database were analyzed, which were searched using keywords: oxytocin, schizophrenia, therapeutic use of oxytocin, social cognition, positive symptoms, negative symptoms and time descriptors: 2013-2017. There are included articles published in Polish and English.
Results:The research results carried out so far suggest that oxytocin plays a significant role in modulating complex socio-emotional behaviors in schizophrenic patients. The existing research results also indicate a relationship between the dysregulation of the oxytocinergic system and the pathophysiology of schizophrenia. Many of the studies prove that there is a relationship between the level of oxytocin in the patients' blood plasma and the severity of the disease symptoms. Recent genetic studies indicate a possible relationship between polymorphism of oxytocin genesand polymorphism of oxytocin receptor genes and the risk of developing schizophrenia.
Conclusions: Contemporary research on the therapeutic potential of oxytocin and its influence on the functioning of schizophrenia patients seem to be very promising and may contribute to increasing the effectiveness of treatment of schizophrenia and possibly other mental disorders, which in turn will improve the quality of life of patients in cognitive, social and emotional functioning.
Characteristics of selected traits of Adult Children of Alcoholics in the context of theirparents’ attitudes
Authors: Zakrzewska Izabela , Samochowiec Agnieszka 
Published: April 2018

Abstract
Children growing up in families with alcohol problems experience many emotions and events that are inadequate to their age. All these experiences are related to their subsequent functioning. Having a mother or a father suffering from alcohol dependence has a big impact on who one becomes in the future and how he/she perceives the world and other people.
The purpose of this study was to determine the relationship between the level of self-esteem, satisfaction with life as well as basic hope in the so-called Adult Children of Alcoholics (ACoA), and the attitudes of their parents.
The study involved 49 persons, aged from 18 to 70. To obtain the necessary data we used the Questionnaire Survey for Adult Children of Alcoholics, Rosenberg Self-Esteem Scale (SES), Satisfaction with Life Scale (SWLS), Basic Hope Inventory (BHI-R) and Re-trospective Assessment of Parental Attitudes Questionnaire (KPR-Roc).
The results show a positive correlation between the level of self-esteem and life satisfaction, and the attitudes of autonomy and acceptance in the mothers of our subjects. Also, life satisfaction, self-esteem and basic hope proved to be interrelated, i.e. an increase within one coincided with an increase in the other two. In addition, our results show that experiencing violence in the families of persons with the ACoA syndrome significantly correlates with the retrospective assessment of their parents' attitudes. Fathers in the so-called violent families are perceived as excessively demanding, yet inconsistent, while mothers as more rejecting and less protecting.
Self-harm - an overview of the tools used to assess non-suicidal self-harming behaviors
Authors: Drzał-Fiałkiewcz Ewelina , Makarewicz Agata , Walczak Mateusz , Walczak Aleksandra , Futyma-Jędrzejewska Małgorzta , Kozak Gustaw , Frończuk Piotr , Karakuła-Juchnowicz Hanna 
Published: April 2018

Abstract
Introduction: Non-Suicidal Self-Injury (NSSI) is the deliberate injury to one’s own body intended to cause mental or physical harm to oneself. In view of the growing scale of the NSSI, especially among young people without identifying any other psychiatric disorders, the disorder was included in both DSM-5 and ICD10 as independent diagnostic entity. Many etiopathogenetic hypotheses and research tools assessing various aspects of NSSI have been developed.
The aim of the work is to present and discuss the most commonly used scales for NSSI assessment.
Method: A review of available literature was made using the databases Medline / PubMed, using the key words: “self injury”, “self-mutilation”, “non-suicidal,”, “NSSI”, “self-harm” and time descriptors: 2005-2017
Results: Available tools were divided into three groups: I- scale of self-assessment made by the patient, II- assessment made by the clinician, and III- auxiliary scale.
Conclusions: None of the available scales covers the complexity of the NSSI phenomenon. For the overall NSSI assessment, several NSSI assessment tools are suggested, taking into account both self-assessment scales and clinical evaluation.
Numerical Modelling and Sensitivity Analysis of Natural Draft Cooling Towers
Authors: Dhorat A. , Al-Obaidi M. A. , Mujtaba I.M. 
Published: April 2018

Abstract
Cooling towers are a relatively inexpensive and consistent method of ejecting heat from several industries such as thermal power plants, refineries, and food processing. In this research, an earlier model from literature was to be validated across three different case studies. Unlike previous models, this model considers the height of the fill as the discretised domain, which produces results that give it in a distribution form along the height of the tower. As there are limitations with the software used (gPROMS) where differential equations with respect to independent variables in the numerator and denominator cannot be solved, a derivative of the saturation vapour pressure with respect to the temperature of the air was presented. Results shown were in agreement with the literature and a parametric sensitivity analysis of the cooling tower design and operating parameters were undertaken. In this work the height of fill, mass flowrates of water and air were studied with respect to sensitivity analysis. Results had shown large variations in the outlet temperatures of the water and air if the mass flows of water and air were significantly reduced. However, upon high values of either variable had shown only small gains in the rejection of heat from the water stream. With respect to the height of the fill, at larger heights of the fill, the outlet water temperature had reduced significantly. From a cost perspective, it was found that a change in the water flowrate had incurred the largest cost penalty with a 1 % increase in flowrate had increased the average operating cost by 1.2 %. In comparison, a change in air flowrate where a 1 % increase in flowrate had yielded an average of 0.4 % increase in operating cost.
Quantitative assessment of urban transport development – a spatial approach
Authors: Czech Artur , Biezdudnaja Anna , Lewczuk Jerzy , Razumowskij Władimir 
Published: April 2018

AbstractUrban transport is considered the basis of properly functioning cities and their development. The main aim of the paper is to attempt the assessment of urban transport development in selected voivodeships (provinces) as a crucial factor of macro logistics. The research also aimed to identify the underdeveloped areas of urban transport in Poland as the basis for the implementation of support policy. The source of information in the investigation process was data drawn from the Central Statistical Office in Poland for 2013–2016. In the scope of dealing with the research problem, chosen classical and order multivariate statistical measures were implemented into the research process. Next, the taxonomic measures for the years of interest served as the basis for the construction of the total (general) synthetic measure applicable to the entire period. The main results and findings of the research indicate that the level of urban transport development is correlated with the whole transportation system which affects the socio-economic development of some regions of Poland. The research can lead to a better understanding of Polish urban transportation development in selected regions. Hence, the results can be helpful in the investment process and for shaping the right transportation policy to improve the use of financial resources.
Polymeric advanced delivery systems for antineoplasic drugs: doxorubicin and 5-fluorouracil
Authors: Villarreal-Gómez Luis Jesús , Serrano-Medina Aracely , José Torres-Martínez Erick , Lizeth Perez-González Graciela , Manuel Cornejo-Bravo José 
Published: April 2018

Abstract
Conventional pharmaceuticals generally display the inability to transport active ingredients directly to specific regions of the body, amongst some of their main limitations. The distribution of the drugs in the circulatory system may lead to undesired toxicity, and therefore, adverse reactions. To address this situation, a selective transport of drugs is required, that is, releasing drugs specifically to the site of action in appropriate concentrations and in the right time. To achieve this goal, it is necessary to develop delivery systems that respond to several features, such as low toxicity, optimum properties for the transport and release of the drug, as well as a long half-life in the body. This feature paper critically provides an overview of different strategies of controlled drug release for two model antineoplasic drugs, i.e. doxorubicin (DOX) and 5-fluorouracil (5-FU). Any of the presented strategies for drug release possess advantages and disadvantages, and the selection of the strategy used will depend on the targeted tissue and nature of the drug.
Job burnout and turnover intention among nurses in China: the mediating effects of positive emotion
Authors: Yang Li-Feng , Liu Jing-Ying , Liu Yan-Hui 
Published: April 2018

Abstract

Objective
The aim of this study was to explore whether positive emotion mediates the relationship between job burnout and turnover intentions among Chinese nurses.

Methods
A cross-sectional survey was conducted in the present study. Full-time registered nurses (n = 150) from Grade A hospitals in Tianjin were surveyed. Pearson correlation, hierarchical regression analyses, and the Sobel test were used in the study.

Results
The results illustrated that positive emotion mediated the relationship between burnout and nurses’ turnover intention.

Conclusions
Nursing administrators should pay more attention to the benefits of positive emotions on working motivation. It is helpful to relieve burnout in the working process so that nurses are willing to remain in their current employment.
Party Leaders and Electoral Realignment: Democratic and Republican Southern Strategies, 1948–1968
Authors: Heersink Boris 
Published: April 2018

Abstract
Political scientists who have studied electoral realignments in the American party system increasingly focus on explaining such changes as the result of major historical developments outside of the control of party leaders. Using both national parties’ approaches to the South in the period 1948–1968, I argue that while party leaders may be unable to cause or prevent a realignment, they do attempt to affect the way in which that process plays out. That is, while the shift of Southern White voters from the Democratic to the Republican Party itself was a largely inevitable process, the timing and context in which it played out was affected by competing strategies from both parties. Specifically, I show that between 1948 and 1964, Democratic leaders hedged their bets between attempting to keep white Southern voters in the party, or expel them in favor of black voters in the Northeast based on their assessments of the party’s electoral position. At the same time, between 1948 and 1968, Republican leaders struggled to balance an appeal to segregationist Southerners and voters in other regions before finding a winning formula in Richard Nixon’s 1968 ‘Southern strategy.’
High Isolation Compact Four-Port MIMO Antenna Loaded with CSRR for Multiband Applications
Authors: Kumar Amit , Ansari Abdul Quaiyum , Kanaujia Binod Kumar , Kishor Jugul 
Published: April 2018

Abstract
In this paper, a compact 4×4 multiple-input-multiple-output (MIMO) patch antenna has been presented for triple band operation. Out of the 4 antennas, two are tuned to cover DCS (Digital Cellular System) downlink and two are tuned to cover DCS uplink frequency separately along with two common operating frequency centered around 2.45 GHz and 875 MHz. Four complementary split-ring resonators (CSRRs) have been etched in the ground plane exactly below the four patch antennas for attaining compactness from 0.36λ02 to 0.13λ02. In addition to this, by optimizing CSRRs outer radius, one lower common band operation of around 875 MHz (0.031λ02) has been obtained. Two, square split-ring resonators (SRRs) are placed between patch antennas to increase isolation by almost 7 dB around DCS band. The proposed MIMO antenna has been fabricated on an FR4 substrate (60×60×0.8) mm3 with dielectric constant, εr=4.3 having an antenna area of 0.13λ02. The Proposed MIMO antenna has two common operating bands, 850–900 MHz, 2410–2466 MHz and one individual band from 1725–1770 MHz for one group of two antennas of dimensions 17×22 mm2 and another individual band from 1800–1845 MHz for another group of two antennas of dimensions 17×23 mm2, where reflection coefficient is less than −10 dB with a minimum isolation of 17 dB. Diversity performance of the proposed MIMO antenna has been verified experimentally on all three bands. However, there is a slight deviation in the DCS operating band due to two different groups of antennas.
Middle and late Badenian palaeoenvironments in the northern Vienna Basin and their potential link to the Badenian Salinity Crisis
Authors: Harzhauser Mathias , Grunert Patrick , Mandic Oleg , Lukeneder Petra , Gallardo Ángela García , Neubauer Thomas A. , Carnevale Giorgio , Landau Bernard M. , Sauer Roman , Strauss Philipp 
Published: April 2018

AbstractHydrocarbon exploration in the Bernhardsthal and Bernhardsthal-Sued oil fields documents an up to 2000 m thick succession of middle and upper Badenian deposits in this part of the northern Vienna Basin (Austria). Based on palaeontological analyses of core-samples, well-log data and seismic surveys we propose an integrated stratigraphy and describe the depositional environments. As the middle/late Badenian boundary is correlated with the Langhian/Serravallian boundary, the cores capture the crucial phase of the Middle Miocene Climate Transition. The middle Badenian starts with a major transgression leading to outer neritic to upper bathyal conditions in the northern Vienna Basin, indicated byBathysiphon-assemblages and glass-sponges. A strong palaeo-relief and rapid synsedimentary subsidence accentuated sedimentation during this phase. The middle/late Badenian boundary coincides with a major drop of relative sea level by about 200 m, resulting in a rapid shift from deeper marine depositional environments to coastal and freshwater swamps. In coeval marine settings, a more than 100 m thick unit of anhydrite-bearing clay formed. This is the first evidence of evaporite precipitation during the Badenian Salinity Crisis in the Vienna Basin. Shallow lagoonal environments with diverse and fully marine mollusc and fish assemblages were established during the subsequent late Badenian re-flooding. In composition, the mollusc fauna differs considerably from older ones and is characterized by the sudden appearance of species with eastern Paratethyan affinities.
p⁢(x)p(x)-biharmonic operator involving the p⁢(x)p(x)-Hardy inequality
Authors: El Khalil Abdelouahed , El Moumni Mostafa , Morchid Alaoui Moulay Driss , Touzani Abdelfattah 
Published: April 2018

Abstract
In this work, we investigate the spectrum denoted by Λ for the

p
⁢

(
x
)

{p(x)}

-biharmonic operator involving the Hardy term.
We prove the existence of at least one non-decreasing sequence of positive eigenvalues of this problem such that

sup
⁡
Λ

=

+
∞

{\sup\Lambda=+\infty}

.
Moreover, we prove that

inf
⁡
Λ

>
0

{\inf\Lambda>0}

if and only if the domain Ω satisfies the

p
⁢

(
x
)

{p(x)}

-Hardy inequality.
Grassland management in protected areas – implementation of the EU biodiversity strategy in certain post-communist countries
Authors: Balázsi Ágnes 
Published: April 2018

Abstract
The post-communist countries of Central-Eastern Europe (CEE) when implementing agricultural and conservation policies, face other challenges than Western European countries: (1) specific institutional design for each, developed on the remnants of totalitarian system causing difficulties for transposing directives; (2) different integration of Natura 2000 network into national protected area governance resulting in slow elaboration of the management plans; (3) farming landscapes were better preserved than in Western Europe, but lacking the continuity of extensive farming so large areas of conservation; and (4) formal protection of sites, lacking in many cases financial support. This paper summarizes: the historical background of the last century that changed the farming landscapes of the CEE countries and the challenges in the management of protected areas in an unsteady socio-economic and political context. The results are focusing on the Czech Republic, Slovakia, Hungary and Romania. Two main conclusions are proposed. First, socialism and capitalism slowly abolished family farming, causing people to become disconnected from the landscape - a key element in conservation oriented grassland management. Second, the gaps of knowledge on different aspects of policy implementation sabotage the results of conservation initiatives.
Twin plots – appropriate method to assess the impact of alien tree on understory?
Authors: Bazalová Denisa , Botková Katarína , Hegedüšová Katarína , Májeková Jana , Medvecká Jana , Šibíková Mária , Škodová Iveta , Zaliberová Mária , Jarolímek Ivan 
Published: April 2018

Abstract
Replacing native forests by alien tree plantations can lead to changes in the species composition of the understory. However, differences in the understory species spectrum can also be a part of the natural variability of forest stands. We have tested the suitability of the twin plots method for an evaluation of the impact of alien trees on the species composition of the understory. This research was conducted on an alluvial plain (SW Slovakia) that was originally covered by a hardwood floodplain forest. The study was based on 7 twin plots of black locust (Robinia pseudoacacia) and native forest plots, with a maximum distance of 100 meters between the members of the twins. The dissimilarity of the plots within the black locust forest was significantly lower than the dissimilarity between the twin plots. In addition, the dissimilarity of the plots within the hardwood floodplain forest was also significantly lower than the dissimilarity between the twin plots. Under the same environmental conditions, the higher dissimilarity of the twin plots was caused by major edificators and their impact on the understory vegetation. The twin plots method proved to be a suitable tool for analyses of the impact of alien trees on understory vegetation.
The Eurasian Dry Grassland Group (EDGG) in 2016–2017
Authors: Venn Stephen , Ambarlı Didem , Biurrun Idoia , Dengler Jürgen , Kuzemko Anna , Török Péter , Vrahnakis Michael 
Published: April 2018

Abstract
This report summarizes the activities and achievements of the Eurasian Dry Grassland Group (EDGG) from mid-2016 through to the end of 2017. During this period, the 13th Eurasian Grassland Conference took place in Sighişoara, Romania, and the 14th conference was held in Riga, Latvia. The 10th EDGG Field Workshop on Biodiversity patterns across a precipitation gradient in the Central Apennine mountains was conducted in the Central Apennines, Italy, this time in addition to multi-scale sampling of vascular plants, bryophytes and lichens, also including one animal group (leaf hoppers). Apart from the quarterly issues of its own electronic journal (Bulletin of the Eurasian Dry Grassland Group), EDGG also finalised five grassland-related Special Features/Issues during the past 1.5 years in the following international journals: Applied Vegetation Science, Biodiversity and Conservation, Phytocoenologia, Tuexenia and Hacquetia. Beyond that, EDGG facilitated various national and supra-national vegetationplot databases of grasslands and established its own specialised database for standardised multi-scale plot data of Palaearctic grasslands (GrassPlot).