bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Victimization to Fear: Fear of Crime and its Variations Among Victims
Authors: Noble Julien , Jardin Antoine 
Published: June 2019

Abstract
The relations between victimization and fear of crime are traditionally studied using binary combinations. Research focuses on whether the fact of having suffered a victimization increases the risk of being afraid, without ever considering the variety of profiles of victimization. We propose to contribute to an elucidation of this phenomenon by examining a group of victims of theft and assault using the accumulated data of systematically repeated victimization surveys in France, and classing these individuals according to the type and intensity of the victimization experienced. We will then look at the relationship between fear of crime and these different profiles. The results show the absence of a single, homogeneous correlation, but rather, the existence of a variety of patterns linking these two variables.
The ADAM17 protease promotes tobacco smoke carcinogen-induced lung tumorigenesis
Authors: Saad Mohamed I , McLeod Louise , Yu Liang , Ebi Hiromichi , Ruwanpura Saleela , Sagi Irit , Rose-John Stefan , Jenkins Brendan J 
Published: June 2019

Abstract
Lung cancer is the leading cause of cancer-related mortality, with most cases attributed to tobacco smoking, in which nicotine-derived nitrosamine ketone (NNK) is the most potent lung carcinogen. The ADAM17 protease is responsible for the ectodomain shedding of many pro-tumorigenic cytokines, growth factors and receptors, and therefore is an attractive target in cancer. However, the role of ADAM17 in promoting tobacco smoke carcinogen-induced lung carcinogenesis is unknown. The hypomorphic Adam17ex/ex mice—characterized by reduced global ADAM17 expression—were backcrossed onto the NNK-sensitive pseudo-A/J background. CRISPR-driven and inhibitor-based (GW280264X, and ADAM17 prodomain) ADAM17 targeting was employed in the human lung adenocarcinoma cell lines A549 and NCI-H23. Human lung cancer biopsies were also used for analyses. The Adam17ex/ex mice displayed marked protection against NNK-induced lung adenocarcinoma. Specifically, the number and size of lung lesions in NNK-treated pseudo-A/J Adam17ex/ex mice were significantly reduced compared with wild-type littermate controls. This was associated with lower proliferative index throughout the lung epithelium. ADAM17 targeting in A549 and NCI-H23 cells led to reduced proliferative and colony-forming capacities. Notably, among select ADAM17 substrates, ADAM17 deficiency abrogated shedding of the soluble IL-6 receptor (sIL-6R), which coincided with the blockade of sIL-6R-mediated trans-signaling via ERK MAPK cascade. Furthermore, NNK upregulated phosphorylation of p38 MAPK, whose pharmacological inhibition suppressed ADAM17 threonine phosphorylation. Importantly, ADAM17 threonine phosphorylation was significantly upregulated in human lung adenocarcinoma with smoking history compared with their cancer-free controls. Our study identifies the ADAM17/sIL-6R/ERK MAPK axis as a candidate therapeutic strategy against tobacco smoke-associated lung carcinogenesis.
Breakdown of Whole-brain Dynamics in Preterm-born Children
Authors: Padilla Nelly , Saenger Victor M , van Hartevelt Tim J , Fernandes Henrique M , Lennartsson Finn , Andersson Jesper L R , Kringelbach Morten , Deco Gustavo , Åden Ulrika 
Published: June 2019

AbstractThe brain operates at a critical point that is balanced between order and disorder. Even during rest, unstable periods of random behavior are interspersed with stable periods of balanced activity patterns that support optimal information processing. Being born preterm may cause deviations from this normal pattern of development. We compared 33 extremely preterm (EPT) children born at &lt; 27 weeks of gestation and 28 full-term controls. Two approaches were adopted in both groups, when they were 10 years of age, using structural and functional brain magnetic resonance imaging data. The first was using a novel intrinsic ignition analysis to study the ability of the areas of the brain to propagate neural activity. The second was a whole-brain Hopf model, to define the level of stability, desynchronization, or criticality of the brain. EPT-born children exhibited fewer intrinsic ignition events than controls; nodes were related to less sophisticated aspects of cognitive control, and there was a different hierarchy pattern in the propagation of information and suboptimal synchronicity and criticality. The largest differences were found in brain nodes belonging to the rich-club architecture. These results provide important insights into the neural substrates underlying brain reorganization and neurodevelopmental impairments related to prematurity.
Bioinformatics Discovery of Putative Enhancers within Mouse Odorant Receptor Gene Clusters
Authors: Farber James E , Lane Robert P 
Published: June 2019

Abstract
Olfactory neuronal function depends on the expression and proper regulation of odorant receptor (OR) genes. Previous studies have identified 54 putative intergenic enhancers within or flanking 40 mouse OR clusters. At least 2 of these putative enhancers have been shown to regulate the expression of a small subset of proximal OR genes. In recognition of the large size of the mouse OR gene family (~1400 OR genes distributed across multiple chromosomal loci), it is likely that there remain many additional not-as-yet discovered OR enhancers. We utilized 23 of the previously identified enhancers as a training set (TS) and designed an algorithm that combines a broad range of epigenetic criteria (histone-3-lysine-4 monomethylation, histone-3-lysine-79 trimethylation, histone-3-lysine-27 acetylation, and DNase hypersensitivity) and genetic criteria (cross-species sequence conservation and transcription-factor binding site enrichment) to more broadly search OR gene clusters for additional candidates. We identified 181 new candidate enhancers located at 58 (of 68) mouse OR loci, including 25 new candidates identified by stringent search criteria whose signal strengths are not significantly different from the 23 previously characterized OR enhancers used as the TS. Additionally, we compared OR enhancer versus generic enhancer features in order to evaluate likelihoods that new enhancer candidates specifically function in OR regulation. We found that features distinguishing OR-specific function are significantly more evident for enhancer candidates located within OR clusters as compared with those in flanking regions.
The Accumulation and Transfers of Wealth: Variations by Social Class
Authors: Hansen Marianne Nordli , Wiborg Øyvind Nicolay 
Published: June 2019

AbstractThe purpose of our study is to investigate the role of wealth in broader stratification processes. Based on unique data from Norwegian tax registers, we address questions about the association between class origin, wealth transfers, and wealth accumulation among young adults. We show that is more common to receive transfers in the higher than in the lower social classes, and that those originating in the economic upper class, i.e. large proprietors, owners, of single enterprises as well as investors with diversified portfolios, and top managers and directors, are especially likely to receive transfers, as well as especially large inter vivos gifts. As young adults, those with upper-class origins, and especially origins in the economic upper class, accumulate more wealth than those with origins in classes lower in the social hierarchy. In all social classes, those who have received wealth transfers accumulate most wealth. We argue that transferring wealth indeed appears as robust and efficient mobility or reproduction strategy.
Mortality among Italian male workers in the construction industry: a census-based cohort study
Authors: Alicandro Gianfranco , Bertuccio Paola , Sebastiani Gabriella , La Vecchia Carlo , Frova Luisa 
Published: June 2019

Abstract

Background
Advances in technologies, occupational hygiene and increased surveillance have reduced the excess mortality previously found in the construction industry. This study is aimed to evaluate cause-specific mortality in a recent cohort of construction workers.

Methods
We carried out a record-linkage cohort study based on the 2011 Italian census and the mortality archives (2012–2015), including 1 068 653 construction workers. We estimated mortality rate ratios (MRR) using Poisson regression models including terms for age and geographic area.

Results
Compared with non-manual workers, construction workers showed an excess mortality from all causes (MRR: 1.34), all neoplasms (MRR: 1.30), head and neck (MRR: 2.05), stomach (MRR: 1.56), liver (MRR: 1.62), lung (MRR: 1.80), prostate (MRR: 1.24) and bladder (MRR: 1.60) cancers, respiratory (MRR: 1.41) and liver (MRR: 1.79) diseases, all external causes (MRR: 1.87), falls (MRR: 2.87) and suicide (MRR: 1.58). Compared with manual workers in other industries, construction workers showed excess mortality from prostate (MRR: 1.27) and non-melanoma skin cancers (MRR: 1.95), all external causes (MRR: 1.14), falls (MRR: 1.94) and suicide (MRR: 1.18). Most of this excess mortality disappeared after adjusting for education, with the exception of prostate and non-melanoma skin cancers, all external causes, falls and suicide.

Conclusions
Construction workers are at high risk of dying from external causes, while the excess mortality found for several cancers, liver and respiratory diseases may be at least partially due to the high prevalence of low education and unfavorable lifestyle factors. The excess mortality from prostate cancer requires further evaluations.
Salivary N-glycosylation as a biomarker of oral cancer: A pilot study
Authors: Sinevici Nicoleta , Mittermayr Stefan , Davey Gavin P , Bones Jonathan , O’Sullivan Jeff 
Published: June 2019

AbstractReliable biomarkers for oral cancer (OC) remain scarce, and routine tests for the detection of precancerous lesions are not routine in the clinical setting. This study addresses a current unmet need for more sensitive and quantitative tools for the management of OC. Whole saliva was used to identify and characterize the nature of glycans present in saliva and determine their potential as OC biomarkers. Proteins obtained from whole saliva were subjected to PNGase F enzymatic digestion. The resulting N-glycans were analyzed with weak anion exchange chromatography, exoglycosidase digestions coupled to ultra-high performance liquid chromatography and/or mass spectrometry. To determine N-glycan changes, 23 individuals with or without cancerous oral lesions were analyzed using Hydrophilic interaction ultra performance liquid chromatography (HILIC–UPLC), and peak-based area relative quantitation was performed. An abundant and complex salivary N-glycomic profile was identified. The main structures present in saliva were neutral oligosaccharides consisting of high mannose, hybrid and complex structures, followed by smaller fractions of mono and di-sialylated structures. To determine if differential N-glycosylation patterns distinguish between OC and control groups, Mann–Whitney testing and principle component analysis (PCA) were used. Eleven peaks were shown to be statistically significant (P ≤ 0.05), while PCA analysis showed segregation of the two groups based on their glycan profile. N-glycosylation changes are active in the oral carcinogenic process and may serve as biomarkers for early detection to reduce morbidity and mortality. Identifying which N-glycans contribute most in the carcinogenic process may lead to their use in the detection, prognosis and treatment of OC.
Still Enigmatic: Innate Immunity in the Ctenophore Mnemiopsis leidyi
Authors: Traylor-Knowles Nikki , Vandepas Lauren E , Browne William E 
Published: June 2019

Abstract
Innate immunity is an ancient physiological response critical for protecting metazoans from invading pathogens. It is the primary pathogen defense mechanism among invertebrates. While innate immunity has been studied extensively in diverse invertebrate taxa, including mollusks, crustaceans, and cnidarians, this system has not been well characterized in ctenophores. The ctenophores comprise an exclusively marine, non-bilaterian lineage that diverged early during metazoan diversification. The phylogenetic position of ctenophore lineage suggests that characterization of the ctenophore innate immune system will reveal important features associated with the early evolution of the metazoan innate immune system. Here, we review current understanding of the ctenophore immune repertoire and identify innate immunity genes recovered from three ctenophore species. We also isolate and characterize Mnemiopsis leidyi cells that display macrophage-like behavior when challenged with bacteria. Our results indicate that ctenophores possess cells capable of phagocytosing microbes and that two distantly related ctenophores, M. leidyi and Hormiphora californiensis, possess many candidate innate immunity proteins.
Validation of Eurolung risk models in a Japanese population: a retrospective single-centre analysis of 612 cases
Authors: Nagoya Akihiro , Kanzaki Ryu , Kanou Takashi , Ose Naoko , Funaki Soichiro , Minami Masato , Shintani Yasushi , Tsutsui Anna , Suga Sayaka , Tajima Tetsuya , Ohno Yuko , Okumura Meinoshin 
Published: June 2019

Abstract

OBJECTIVES
The objective of this study was to evaluate the validity of Eurolung risk models in a Japanese population and assess their utility as predictive indicators for the prognosis.

METHODS
Between 2007 and 2014, 612 anatomic lung resections were performed among 694 lung cancer patients in our institution. We analysed the cardiopulmonary morbidity and mortality and compared them with the predicted results. We also investigated the association between the Eurolung aggregate risk scores and the long-term outcomes using the Kaplan–Meier method and a multivariable analysis.

RESULTS
The percentage of cardiopulmonary complications was lower than that predicted by Eurolung 1 (22.4% vs 24.6%). The mortality rate was significantly lower than predicted by Eurolung 2 (0.7% vs 3.0%). The morbidity rate was stratified by Aggregate Eurolung 1. The stratification of the mortality rate by the Eurolung 2 aggregate score was also in line with the increase in score, although the observed number of deaths was quite small (4 cases). The 5-year overall survival was clearly separated according to the stratified Aggregate Eurolung 1 and 2 (P < 0.01 and P < 0.01, respectively). Besides pathological stage, both the Aggregate Eurolung 1 (score 0–7 vs 8–20) and 2 (score 0–8 vs 9–19) scores were shown to be independently associated with overall survival on multivariable.

CONCLUSIONS
Eurolung risk models cannot be directly applied to the patients in our institution. However, Eurolung aggregate risk scores were helpful not only for stratifying morbidity and mortality after anatomic lung resection but also for predicting the long-term outcomes.
Isotropic Cuspidal Functions in the Hall Algebra of a Quiver
Authors: Hennecart Lucien 
Published: June 2019

AbstractFrom the structure of the category of representations of an affine cycle-free quiver, we determine an explicit linear form on the space of cuspidal regular functions over a finite field: its kernel is exactly the space of cuspidal functions. Moreover, we show that any isotropic cuspidal dimension has an affine support. Brought together, this two results give an explicit description of isotropic cuspidal functions of any quiver. The main theorem, together with an appropriate action of some permutation group on the Hall algebra, provides a new elementary proof of two conjectures of Berenstein and Greenstein previously proved by Deng and Ruan. We also prove a statement giving non-obvious constraints on the support of the comultiplication of a cuspidal regular function allowing us to connect both mentioned conjectures of Berenstein and Greenstein. Our results imply the positivity conjecture of Bozec and Schiffmann concerning absolutely cuspidal polynomials in isotropic dimensions.
Resistance to critically important antimicrobials in Australian silver gulls (Chroicocephalus novaehollandiae) and evidence of anthropogenic origins
Authors: Mukerji Shewli , Stegger Marc , Truswell Alec Vincent , Laird Tanya , Jordan David , Abraham Rebecca Jane , Harb Ali , Barton Mary , O’Dea Mark , Abraham Sam 
Published: June 2019

Abstract

Objectives
Antimicrobial resistance (AMR) to critically important antimicrobials (CIAs) amongst Gram-negative bacteria can feasibly be transferred amongst wildlife, humans and domestic animals. This study investigated the ecology, epidemiology and origins of CIA-resistant Escherichia coli carried by Australian silver gulls (Chroicocephalus novaehollandiae), a gregarious avian wildlife species that is a common inhabitant of coastal areas with high levels of human contact.

Methods
Sampling locations were widely dispersed around the perimeter of the Australian continent, with sites separated by up to 3500 km. WGS was used to study the diversity and molecular characteristics of resistant isolates to ascertain their epidemiological origin.

Results
Investigation of 562 faecal samples revealed widespread occurrence of extended-spectrum cephalosporin-resistant (21.7%) and fluoroquinolone-resistant (23.8%) E. coli. Genome sequencing revealed that CIA-resistant E. coli isolates (n = 284) from gulls predominantly belonged to human-associated extra-intestinal pathogenic E. coli (ExPEC) clones, including ST131 (17%), ST10 (8%), ST1193 (6%), ST69 (5%) and ST38 (4%). Genomic analysis revealed that gulls carry pandemic ExPEC-ST131 clades (O25:H4 H30-R and H30-Rx) and globally emerging fluoroquinolone-resistant ST1193 identified among humans worldwide. Comparative analysis revealed that ST131 and ST1193 isolates from gulls overlapped extensively with human clinical isolates from Australia and overseas. The present study also detected single isolates of carbapenem-resistant E. coli (ST410-blaOXA-48) and colistin-resistant E. coli (ST345-mcr-1).

Conclusions
The carriage of diverse CIA-resistant E. coli clones that strongly resemble pathogenic clones from humans suggests that gulls can act as ecological sponges indiscriminately accumulating and disseminating CIA-resistant bacteria over vast distances.
Distribution of Pheromone Biosynthesis-Activating Neuropeptide in the Central Nervous System of Plutella xylostella (Lepidoptera: Plutellidae)
Authors: Chen Yong , Liu Yuyan , Tian Houjun , Chen Yixin , Lin Shuo , Mao Qianzhuo , Zheng Nan , Zhao Jianwei , Gu Xiaojun , Wei Hui 
Published: June 2019

AbstractInsect neuropeptides in the pyrokinin/pheromone biosynthesis-activating neuropeptide (PBAN) family are actively involved in many essential endocrinal functions and serve as potential targets in the search for novel insect control agents. Here, we dissect the nervous system of larval, pupal, and adult Plutella xylostella (L.) (Lepidoptera: Plutellidae) and describe the ganglion morphology and localization of PBAN during different insect developmental stages. Our results show that the central nervous system (CNS) of this species consists of four types of ganglia: cerebral ganglia (brain), subesophageal ganglion (SEG), thoracic ganglia, and abdominal ganglia. A two-lobed brain is connected to the reniform SEG with a nerve cord in larvae and prepupae, whereas in the late pupae and adults, the brain and SEG are fused, forming a brain–SEG complex. The larvae and prepupae have eight abdominal ganglia each, whereas the late pupae and adults each have four abdominal ganglia. Furthermore, all life stages of P. xylostella had similar patterns of PBAN immunoreactivity in the CNS, and the accumulation of PBAN was similar during all life stages except in adult males. PBAN immunoreactive signals were observed in the brain and SEG, and fluorescence signals originating in the SEG extended the entire length of the ventral nerve cord, ending in the terminal abdominal ganglia. Our results provide morphological data that inform the development and evolution of the CNS. In addition, they indicate that the nervous system contains PBAN, which could be used to control P. xylostella populations.
Host Potential and Adaptive Responses of Drosophila suzukii (Diptera: Drosophilidae) to Barbados Cherries
Authors: Mendonca Larine de Paiva , Oliveira Eugenio Eduardo , Andreazza Felipe , Rezende Sarah Miranda , Faroni Lêda Rita D’Antonino , Guedes Raul Narciso Carvalho , Haddi Khalid 
Published: June 2019

Abstract
Biological invasions are a global threat to agricultural crops worldwide. In the Neotropical region, the spotted-wing Drosophila [Drosophila suzukii (Matsumura)] has rapidly expanded its geographical range spreading throughout South America in recent years. Besides climatic factors, the remarkable success of its establishment and subsequent distribution in this region is closely dependent on the diversity and availability of host plants. We evaluated the host potential (e.g., as food and oviposition sources) of fruits of jabuticaba [Plinia cauliflora (Mart.) Kausel (Myrtales: Myrtaceae)], Barbados cherry (Malpighia emarginata DC) (Malpighiales: Malpighiaceae), bonnet pepper (Capsicum chinense Jacq.) (Solanales : Solanaceae), and coffee (Coffea arabica L.) (Gentianales : Rubiaceae) and their effects on the biological and physiological traits of D. suzukii. For the fruit types where fly emergence occurred, we assessed the biological and physiological performance of the flies and compared these parameters with those recorded for flies reared on strawberries (Fragaria × ananassa Duchesne) (Rosales : Rosaceae) and an artificial diet. Our results revealed that oviposition into fruits and completion of the life cycle occurred on Barbados cherries only. Furthermore, field surveys revealed a higher emergence rate of D. suzukii on undamaged ripe Barbados cherries than damaged ones. Moreover, flies developing on Barbados cherries and an artificial diet presented earlier emergence, shorter developmental time, lower number of adults per female, and a female-biased sex ratio compared to flies developing on strawberries. Overall, our findings demonstrated suitability of Barbados cherry as a host for D. suzukii, which renders management of D. suzukii in Neotropical region an even more challenging task.
Regulatory networks between Polycomb complexes and non-coding RNAs in the central nervous system
Authors: Xu Ya-Jie , Liu Pei-Pei , Ng Shyh-Chang , Teng Zhao-Qian , Liu Chang-Mei 
Published: June 2019

Abstract
High-throughput sequencing has facilitated the identification of many types of non-coding RNAs (ncRNAs) involved in diverse cellular processes. NcRNAs as epigenetic mediators play key roles in neuronal development, maintenance, and dysfunction by controlling gene expression at multiple levels. NcRNAs may not only target specific DNA or RNA for gene silence but may also directly interact with chromatin-modifying proteins like Polycomb group (PcG) proteins to drive orchestrated transcriptional programs. Recent significant progress has been made in characterizing ncRNAs and PcG proteins involved in transcriptional, post-transcriptional, and epigenetic regulation. More importantly, dysregulation of ncRNAs, PcG proteins, and interplay among them is closely associated with the pathogenesis of central nervous system (CNS) disorders. In this review, we focus on the interplay between ncRNAs and PcG proteins in the CNS and highlight the functional roles of the partnership during neural development and diseases.