bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequestration of RBM10 in Nuclear Bodies: Targeting Sequences and Biological Significance
Authors: Wang Ling-Yu , Xiao Sheng-Jun , Kunimoto Hiroyuki , Tokunaga Kazuaki , Kojima Hirotada , Kimura Masatsugu , Yamamoto Takahiro , Yamamoto Naoki , Hong Zhao , Nishio Koji , Tani Tokio , Nakajima Koichi , Sunami Kishiko , Inoue Akira 
Published: January 2019

AbstractRBM10 is an RNA-binding protein that regulates alternative splicing (AS). It localizes to the extra-nucleolar nucleoplasm and S1-1 nuclear bodies (NBs) in the nucleus. We investigated the biological significance of this localization in relation to its molecular function. Our analyses, employing deletion mutants, revealed that RBM10 possesses two S1-1 NB-targeting sequences (NBTSs), one in the KEKE motif region and another in the C2H2 Zn finger (ZnF). These NBTSs act synergistically to localize RBM10 to S1-1 NBs. The C2H2 ZnF not only acts as an NBTS, but is also essential for AS regulation by RBM10. Moreover, RBM10 does not participate in S1-1 NB formation, and without alterations of RBM10 protein levels, its NB-localization changes, increasing as cellular transcriptional activity declines, and vice versa. These results indicate that RBM10 is a transient component of S1-1 NBs and is sequestered in NBs via its NBTSs when cellular transcription decreases. We propose that the C2H2 ZnF exerts its NB-targeting activity when RBM10 is unbound by pre-mRNAs, and that NB-localization of RBM10 is a mechanism to control its AS activity in the nucleus.Note that the previous title of this manuscript was Targeting of RBM10 to S1-1 Nuclear Bodies: Targeting Sequences and its Biological Significance.
NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity
Authors: Haider Nasir , Dutt Previn , van de Kooij Bert , Yaffe Michael , Stambolic Vuk 
Published: January 2019

ABSTRACTIn response to genotoxic stress, multiple kinase signalling cascades are activated, many of them directed towards the tumour suppressor p53 which coordinates the DNA damage response (DDR). Defects in DDR pathways lead to an accumulation of mutations that can promote tumorigenesis. Emerging evidence implicates multiple members of the NimA-related kinase (NEK) family (NEK1, NEK10 and NEK11) in the DDR. Here, we describe a function for NEK10 in the regulation of p53 transcriptional activity through tyrosine phosphorylation. NEK10 loss increases cellular proliferation through modulation of the p53-dependent transcriptional output, by directly phosphorylating p53 on Y327, revealing NEK10’s unexpected substrate specificity. A p53 mutant at this site (Y327F) acts as a hypomorph, causing an attenuated p53-mediated transcriptional response. Consistently, NEK10-deficient cells display heightened sensitivity to DNA damaging agents and low NEK10 expression is an independent predictor of a favorable response to radiation treatment in WT TP53 breast cancer patients.
The effects of a TMS double lesion to a cortical network
Authors: Cameron Ian G.M. , Cretu Andreea , Struik Femke , Toni Ivan 
Published: January 2019

AbstractTranscranial magnetic stimulation (TMS) has contributed to our understanding of the functions of individual brain regions, but its use to examine distributed functions throughout a network has been more limited. We assess the functional consequences of a TMS pulse to the oculomotor network which was first perturbed by continuous theta-burst stimulation (cTBS), to examine the potential for additive effects from lesions to two network nodes. Twenty-three humans performed pro-(look towards) and anti-(look away) saccades after receiving cTBS to right frontal eye fields (FEF), dorsolateral prefrontal cortex (DLPFC) or somatosensory cortex (S1) (control). On a subset of trials, a TMS pulse was applied to right posterior parietal cortex (PPC). We assessed changes in saccade amplitudes, performance (percentage correct) and reaction times, as these parameters relate to computations in networks involving these nodes. We observed impairments in ipsilateral anti-saccade amplitudes following DLPFC cTBS that were enhanced by a PPC pulse, but that were not enhanced relative to the effect of the PPC pulse alone. There was no evidence for effects from the double lesion to performance or reaction times. This suggests that computations are distributed across the network, such that even a single lesion is consequential.
Candidate regulators and target genes of drought stress in needles and roots of Norway spruce
Authors: Haas Julia C. , Vergara Alexander , Hurry Vaughan , Street Nathaniel R. 
Published: January 2019

AbstractDrought stress impacts on seedling establishment, survival and whole-plant productivity. Drought stress responses have been extensively studied at the physiological and molecular level in angiosperms, particularly in agricultural species and the modelArabidopsis thaliana, with the vast majority of work performed on aboveground tissues. Boreal forests are dominated by coniferous tree species and cover vast areas of the terrestrial surface. These areas are predicted to be particularly influenced by ongoing climate change and will be exposed to more frequent and acute drought. The associated impact at all stages of the forest tree life cycle is expected to have large-scale ecological and economic impacts. To provide a comprehensive understanding of the drought response mechanisms ofPicea abiesseedlings, we assayed the physiological response of needles and transcriptional responses of roots and needles after exposure to mild and severe drought. Shoots and needles showed extensive reversible plasticity for physiological measures indicative of drought response mechanisms, including stomatal conductance (gs) and shoot water potential. Root and needle transcriptional responses contrasted, with an extensive root-specific down-regulation of growth. When we compared the responses ofP. abieswith previously-characterisedA. thalianadrought response genes, we found that the majority of the genes were conserved across lineages. However, inP. abies, transcription factors (TFs) previously identified as belonging to the ABA-dependent pathway had a more limited role and most differentially expressed genes were specific to the stress response ofP. abies. These results highlight the importance of profiling both above- and below-ground tissues and provide a comprehensive framework to advance understanding of the drought response mechanism ofP. abies.One sentence summaryAnalysis of the drought transcriptome of Norway spruce reveals divergent molecular response pathways in conifers.
Beyond reach: an extended model of global brand effects
Authors: Mandler Timo 
Published: January 2019

PurposeDespite considerable investigations of the various outcomes of perceived brand globalness (PBG), the concept itself remains ambiguous, demanding further conceptual refinement. The purpose of this paper is to contribute to global branding literature by suggesting an extended conceptualization of PBG, and empirically testing a corresponding extended model of global brand effects, relative to the conventional operationalization.Design/methodology/approachAn empirical study (n=907) involving 63 brands across eight different product categories provides new insights into the composition of global brand effects by explicitly discriminating between different facets of consumers’ brand globalness perceptions (i.e. perceived market reach (PMR), perceived standardization (PST) and global consumer culture positioning (GCCP)).FindingsThe results clearly show that effects associated with global brands are not exclusively positive. While PMR and GCCP have positive effects on consumers’ brand evaluations and attitudes, PST has a strong negative effect on the same outcomes. These effects apply to both domestic and foreign global brands and occur irrespective of the perceived level of risk associated with a given product category.Originality/valueThe results provide managers a clearer picture of the up- and downsides of brand globalness perceptions and urge future studies on global brands to incorporate constructs that account for facets beyond a brand’s market reach to capture the phenomenon holistically.
Disentangling anti-corruption agencies and accounting for their ineffectiveness
Authors: Krambia-Kapardis Maria 
Published: January 2019

Purpose
The purpose of this paper is to provide an adequate account of anti-corruption agency (ACA) ineffectiveness and propose the kind of ACA that would hold the promise of success. The paper draws on legitimacy theory, legal process and the notion of integrity of purpose.

Design/methodology/approach
This paper contextualizes the establishment and proliferation of ACAs; explores different ways of conceptualizing them; examines the broad range of factors that have underpinned ACA ineffectiveness and utilizes both legitimacy theory and the notion of the integrity of purpose.

Findings
The one-ACA-model-fits-all approach in corruption-control has been an abysmal failure. Disentangling the reasons for ACA ineffectiveness reveals various endogenous and exogenous factors. It also emphasizes the crucial importance of integrating both legitimacy theory and integrity of purpose in a revamped ACA concept that meets the corruption-control challenge.

Practical implications
It is possible to design and implement an effective ACA by avoiding various factors that have been shown to seriously undermine corruption control efforts by also drawing on legitimacy theory, legal process and integrity of purpose.

Social implications
Corruption in both the public and private sectors cannot be controlled in isolation from other socio-economic problems. An effective ACA is one that fosters integrity and is considered legitimate by its stakeholders.

Originality/value
While there have been some articles the past two decades discussing the effectiveness of ACAs in particular countries, this is the first paper to account for the overall ACA ineffectiveness also using legitimacy theory, legal process and integrity of purpose to revamp the ACA concept.
Predicting susceptibility to cyber-fraud victimhood
Authors: Whitty Monica T. 
Published: January 2019

Purpose
This paper aims to develop a theoretical framework to predict susceptibility to cyber-fraud victimhood.

Design/methodology/approach
A survey was constructed to examine whether personality, socio-demographic characteristics and online routine activities predicted one-off and repeat victimhood of cyber-fraud. Overall, 11,780 participants completed a survey (one-off victims, N = 728; repeat victims = 329).

Findings
The final saturated model revealed that psychological and socio-demographic characteristics and online routine activities should be considered when predicting victimhood. Consistent with the hypotheses, victims of cyber-frauds were more likely to be older, score high on impulsivity measures of urgency and sensation seeking, score high on addictive measures and engage in more frequent routine activities that place them at great risk of becoming scammed. There was little distinction between one-off and repeat victims of cyber-frauds.

Originality/value
This work uniquely combines psychological, socio-demographic and online behaviours to develop a comprehensive theoretical framework to predict susceptibility to cyber-frauds. Importantly, the work here challenges the current utility of government websites to protect users from becoming scammed and provides insights into methods that might be used to protect users from becoming scammed.
How modern psychology can help us understand white-collar criminals
Authors: Dearden Thomas E. 
Published: January 2019

PurposeThis paper aims to add to the theoretical discussion of white-collar crime by introducing modern psychological decision-making literature and the potential effect on white-collar offending.Design/methodology/approachUsing a theoretical approach, literature on heuristics, innovation and stress, insight into why white-collar offenders decide to commit crime is posited.FindingsThe heuristics and strategies that people use to assist in decision-making process may inadvertently promote white-collar crime. For example, stress may inhibit white-collar offenders’ thinking, causing them to discount the risk of committing said offense; individuals may not challenge the success of carrying out a white-collar offense once it is considered; and generally, people will be more optimistic in considering their success of not getting caught.Originality/valueCurrently, the study of white-collar crime is discussed largely in the context of sociological factors. Current psychological theories have considerable explanatory power in understanding why white-collar offenders commit their crimes.
Christian attitudes toward ethics of tax evasion: a case study
Authors: McGee Robert W. , Benk Serkan 
Published: January 2019

Purpose
The purpose of this study is to examine Christian views on the ethics of tax evasion.

Design/methodology/approach
To achieve this objective, data were gathered from the most recent World Values Survey, which included 60 countries. The sample size exceeded 30,000. Various demographic variables were also examined, such as gender, age, marital status, education level, income level, social class, position on the political spectrum and others.

Findings
This study found that although there was widespread opposition to tax evasion, it could be justified sometimes. Not all Christian sects had the same view of tax evasion. Some sects were less severe in their opposition than others. This study ranked the various sects from least to most opposed.

Originality/value
The present study expands the religions literature by showing that differing Christian sects have opinions on the ethics of tax evasion that differ significantly, and that it cannot be said categorically that the more conservative Christian sects are either more opposed or less opposed to tax evasion than are the liberal or moderate sects.
Antecedents of consumers’ reliance on online product reviews
Authors: Mumuni Alhassan G. , Lancendorfer Karen M. , O’Reilly Kelley A. , MacMillan Amy 
Published: January 2019

PurposeThis paper examines the role that attitudes toward online product reviews (OPRs), perceived credibility of OPRs and perceived benefit of OPRs play as antecedents of consumers’ reliance on OPRs in purchase decisions. A conceptual model of relationships investigated posits that attitudes drive reliance and are in turn driven by perceived benefit and credibility of OPRs. The study also examines gender differences in the constructs and their inter-relationships.Design/methodology/approachData from a structured self-administered survey of US consumers are used to estimate parameters of a structural equation model (SEM) of the relationships. Gender differences in the structural relationships are tested using multi-group SEM, while gender differences in reliance, attitudes, benefit and credibility are tested using independent-samplest-tests.FindingsResults show a strong positive effect of attitudes toward OPRs on reliance on OPRs. In turn, perceived benefit and credibility of OPRs are strong positive drivers of attitudes toward OPRs, with benefit having a greater impact. Structural relationships among the constructs are invariant across the two gender groups. However, there is a statistically significant difference between males and females in reliance on OPRs, with males exhibiting a tendency to rely more on OPRs than females.Originality/valueThe study introduces two new constructs to the literature – reliance on OPRs and global attitudes toward OPRs – and provides initial conceptualizations and operationalizations. The specific results underscore the relevance and importance of further research on these constructs and their relationships with other OPR-relevant constructs. They also provide initial indications of gender differences in consumers’ perceptions of OPRs and relationships among these and reliance on OPRs that are worthy of additional research attention.
Sink limitation of plant growth determines tree line in the arid Himalayas
Authors: Dolezal Jiri , Kopecky Martin , Dvorsky Miroslav , Macek Martin , Rehakova Klara , Capkova Katerina , Borovec Jakub , Schweingruber Fritz , Liancourt Pierre , Altman Jan 
Published: January 2019

Abstract

Understanding what determines the high elevation limits of trees is crucial for predicting how tree lines may shift in response to climate change. Tree line formation is commonly explained by a low‐temperature restriction of meristematic activity (sink limitation) rather than carbon assimilation (source limitation). In arid mountains, however, trees face simultaneously low temperature and drought, both potentially restricting their growth and thus setting range limits. However, the mechanisms of tree line formation in high arid mountains are largely unknown.

We studied Myricaria elegans, one of the world’s highest growing winter‐deciduous woody species, endemic to the arid Himalayas. We hypothesized that the upper elevation limit of Myricaria is associated with low temperatures during the early growing season affecting earlywood formation, while later in the season drought is constraining earlywood maturation and latewood formation.

To test this hypothesis, we studied the quantitative anatomy of tree rings at different developmental stages across the entire species elevation range (3,200–4,400 m). We also explored daily stem increment and rehydration rates, seasonal dynamics of non‐structural carbohydrates and stable C isotopes as a proxy for possible drought constraints.

Both earlywood and latewood increments decreased towards the tree line, while NSC in leaves, twigs and stem sapwood did not change, indicating a sink limitation as a main driver of the tree line. At tree line, low temperatures restricted earlywood formation more than latewood formation. Tree line individuals had—compared to individuals from lower elevations—smaller and fewer earlywood vessels, frequent frost rings and shorter periods with positive daily increments, but comparable night‐time stem rehydration rates and latewood density. All these results suggest a sink limitation as a main mechanism behind the tree line formation in high arid mountains.

In the arid Himalayas, the tree line is set by the drastic growth reduction (sink limitation) caused by low temperature and short growing season under otherwise sufficient carbon and water supply. At the tree line, spring freezing and high summer temperatures further constrain annual stem increment. The mean 6.9°C temperature during the growing season places the Myricaria tree line within the thermal range of other high elevation tree lines worldwide and supports a common mechanism of alpine tree line formation.

A plain language summary is available for this article.
Acid exposure in patients with gastroesophageal reflux disease is associated with esophageal dysmotility
Authors: Jiang Liu Qin , Ye Bi Xing , Wang Mei Feng , Lin Lin 
Published: January 2019

ObjectiveTo explore the correlation between reflux disease and abnormal esophageal motility in patients with gastroesophageal reflux disease (GERD).MethodsParticipants (patients with GERD and controls) who underwent 24‐h impedance‐pH monitoring (MII‐pH monitoring) and high‐resolution manometry between January 2012 and February 2017 were retrospectively studied. The patients were divided into two groups (acid reflux and nonacid reflux) based on their MII‐pH monitoring data. Reflux episodes, endoscopic findings, and esophageal dynamic parameters were assessed and compared.ResultsA total of 142 patients were included (acid reflux [n = 58], nonacid reflux [n = 60], control group [n = 24]). There were more patients with esophagitis and more severe esophageal mucosal injury in the acid reflux group than in the nonacid reflux group. The acid reflux group had reduced lower esophageal sphincter (LES) basal pressure, shorter LES length, lower esophageal pressure and distal contractile integral index than the nonacid reflux group. Patients in the acid reflux group had more large breaks and a higher incidence of type II and III esophagogastric junction morphology than those in the nonacid reflux group. Acid exposure time, the incidence of long‐term acid reflux, recumbent acid reflux, and the incidence of acid and nonacid reflux had a significant negative correlation with esophageal body motility or LES function.ConclusionThis study suggests that an increase in esophageal acid exposure is correlated with an increase in esophageal dysmotility in patients with GERD.
Survival comparison of right and left side non‐small cell lung cancer in stage I–IIIA patients: A Surveillance Epidemiology and End Results (SEER) analysis
Authors: Jia Bo , Zheng Qiwen , Qi Xinmeng , Zhao Jun , Wu Meina , An Tongtong , Wang Yuyan , Zhuo Minglei , Li Jianjie , Zhao Xinghui , Yang Xue , Zhong Jia , Chen Hanxiao , Dong Zhi , Shi Youwu , Du Feng , Wang Jingjing , Chi Yujia , Zhai Xiaoyu , Wang Ziping 
Published: January 2019

BackgroundPrimary tumors located in the right and left side have distinctive prognoses, but the details have not been fully identified in non‐small cell lung cancer (NSCLC). This study investigated the impact of primary tumor side on long‐term survival in NSCLC patients.MethodsData of 90 407 patients from the Surveillance, Epidemiology, and End Results (SEER) Program were analyzed. To avoid bias between groups, we used innovative propensity score matching (PSM) analysis.ResultsThere was no significant distinction in overall survival (OS) between right (n = 53 496) and left (n = 36 911) side tumors (hazard ratio [HR] 0.993, 95% confidence interval [CI] 0.9756–1.011; P = 0.432). Left side was associated with superior five‐year cancer‐specific survival (CSS) compared to right side NSCLC (HR 0.977, 95% CI 0.9574–0.9969; P = 0.024). No significant difference was observed in OS (P = 0.689) or CSS (P = 0.288) after PSM analysis. In the 51 319 patients who underwent surgery, left side (n = 21 245) was associated with poor OS compared to right side (n = 30 074) NSCLC (HR 1.039, 95% CI 1.011–1.067; P = 0.006), while CSS was similar (HR 1.031, 95% CI 0.997–1.065; P = 0.069). In patients who underwent surgery, there was also no significant difference in OS (P = 0.986) or CSS (P = 0.979) after PSM analysis.ConclusionThe prognosis between right and left side NSCLC in stage I–IIIA was similar regardless of whether patients underwent surgery. Primary tumor side cannot be considered a prognostic factor when choosing appropriate treatment.
Mandatory corporate social responsibility disclosure and dividend payouts: evidence from a quasi‐natural experiment
Authors: Ni Xiaoran , Zhang Huilin 
Published: January 2019

AbstractEmploying the enactment of a regulation that mandates a subset of firms to disclose their corporate social responsibility (CSR) activities as a quasi‐natural experiment, we find that mandatory CSR disclosure reduces firms’ dividend payouts significantly. Further analyses indicate that the negative relation is more pronounced for firms with weaker corporate governance mechanisms, where shareholders lack of effective tools to protect themselves against pressures from stakeholders, and a shift of relative power towards stakeholders is more likely to occur. Our paper provides a specific channel through which mandatory CSR disclosure benefits stakeholders at the expense of shareholders.