bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Future of Facial Fat Grafting
Authors: Brooker Jack E. , Rubin J. Peter , Marra Kacey G. 
Published: March 2019

Abstract
Fat grafting was first described in the early 20th century but for many years remained a relatively underused technique due to the unreliability of long-term volume expansion. Significant improvements in reliability have been made in the last 2 decades and there is a large body of literature pertaining to extraction, processing and injection methods to obtain more lasting effects. However, volume loss and graft resorption remain a major challenge in the long term and lead to unpredictability in results. Enriching adipose graft with stromal vascular fraction, ex vivo cultured adipose stem cells and platelet-derived growth factor among others is one method under active investigation which may assist graft survival through a range of mechanisms including increased angiogenesis. Breaking adipose graft into smaller fragments such that engrafted cells have greater access to donor-site oxygenation and nutrition is another method which in theory may promote survival. Presently, adipose grafting in the face is usually for the addition of volume to fill defects. However, the stem-cell containing fraction of adipose grafting (stromal vascular fraction) appears to exert a rejuvenating effect on overlying skin and soft tissue when administered alone. The application of these low-volume injections represents a significant shift in thinking away from mere volume expansion. These techniques have been tested in a range of animal models and some human studies. In this review, the authors provide a broad overview of present research and highlight both limitations in previous research and current areas of investigation.
The Influence of the First-Stage DO Treatment of Palate Defect on Growth of Maxilla
Authors: Liu Shiqi , Wang Hui , Zhou Nuo , Yang Lianghui , Fang Fang , Zhang Chong , Mai Huaming 
Published: March 2019

Abstract
To study the influence of distraction osteogenesis (DO) on the maxillary growth as first-stage treatment of palatal defect. The uniform palate defect experimental animal models (21 miniature pigs) were established surgically. Then animals were randomly divided into negative control group (A, n = 6), conventional surgery group (B, n = 6), and distraction osteogenesis group (C, n = 9) respectively. The group A underwent none treatment as control group, the group B were undergoing a conventional defect repair surgery, and the group C were undergoing a distraction osteogenesis treatment. Cone beam computed tomography examination was performed monthly to analyze the growth of maxilla for 6 months. One pig of group C was randomly sacrificed at 2, 4, and 8 weeks after the completion of DO and the tissue of distraction gap was stained with hematoxylin–eosin and Masson staining. At the end of 6th months, all pigs were sacrificed and tissues of the surgical area were stained as previous described. The palate defect was repaired by the distraction osteogenesis with the successful bone formation on the distraction gap. Group A and group C kept a similar growth rate, but that of group B was relatively slow. Distraction osteogenesis is efficient and successful for closing the defect of palate and there is no significant disturbance on the subsequent growth of the maxilla.
Enucleations and Eviscerations for Combat Ocular Trauma Performed During Operations Iraqi and Enduring Freedom: 2001 to 2011
Authors: Stevens Bryan J. , Justin Grant A. , Reed Donovan S. , Jaksha Alexandria F. , Davies Brett W. , DeMartelaere Sherri L. , Ryan Denise S. , Weichel Eric D. , Colyer Marcus H. 
Published: March 2019

Purpose:
To describe the demographics and clinical outcomes of patients who underwent posttraumatic enucleation or evisceration during Operations Iraqi Freedom (OIF) and Enduring Freedom (OEF) from 2001 to 2011.

Methods:
The Walter Reed Ocular Trauma Database is a retrospective case series of US Servicemembers and Department of Defense civilians who had combat ocular injuries in OIF and OEF. Data regarding posttraumatic enucleations and eviscerations performed during OIF and OEF were extracted. The main outcomes analyzed were the number of enucleations and eviscerations performed, location of the surgery, laterality, and graft type. The secondary outcome measures included: mechanism of injury and Ocular Trauma Score classification.

Results:
One hundred nine enucleations and eviscerations were performed on the 890 eyes (12.24%). Sixty-three (57.80%) primary enucleations, 36 (33.03%) secondary enucleations, 5 (4.59%) postretinal detachment repair enucleations, and 5 (4.59%) primary eviscerations were completed. The surgeries were completed at a combat support hospital (57; 52.3%), or Walter Reed Army Medical Center (49; 45.0%). All surgeries were unilateral except in 2 patients. The most common graft type used was silicone (n = 56; 51.38%). Improvised explosive devices caused 76 (69.72%) eye injuries. Ocular Trauma Score were recorded as 56 (51.38%) between 0 and 44, 44 (40.37%) between 45 and 65, and unknown in 9 (8.26%).

Conclusion:
Posttraumatic enucleation or evisceration due to devastating ocular trauma is required in about 15% of ophthalmic patients in modern combat trauma. The psychosocial impact on veterans who have required an enucleation or evisceration from combat trauma has been poorly studied and requires further review.
Face Dissection as the Plastic Surgery Approach: Effective Method in Residency Training
Authors: Jung Joo Sung , Kang Dong Hee , Lim Nam Kyu 
Published: March 2019

Purpose:
The global trend of resident work-hour restrictions requires a more time efficient way of resident training. Among many training programs for learning the facial anatomy, the cadaver is the most similar to live patients. A cadaver should be used as efficiently as possible due to human dignity as well as the consideration of cost. The authors designed an effective cadaver dissection method in learning facial anatomy using the plastic surgery approach.

Method:
A 51-year-old male cadaver was used for dissection. The program was proceeded 6 times over 6 weeks, and 4 to 8 hours each day. We used standard surgical instruments with magnifying loupes. The results were analyzed through a numerical scale survey.

Result:
We planned to dissect the face from medial to lateral, cephalic to caudal, and superficial to deep portion. The overall knowledge and confidence level of the face were increased in all 7 participants. The mean knowledge level before and after the seminar was 3.00 and 4.03, respectively. Confidence level also increased through the seminar from 1.86 to 2.86.

Conclusion:
The authors believe this cadaver dissection program could optimize learning anatomical knowledge and improve resident's surgical confidence through a wide range of procedures.
The Impact of Harvesting Systems and Donor Characteristics on Viability of Nucleated Cells in Adipose Tissue: A First Step Towards a Manufacturing Process
Authors: Papadopulos Nikolaos A. , Wigand Sylvia , Kuntz Nicolas , Piringer Marion , Machens Hans-Günther , Klüter Harald , Bieback Karen , Karagianni Marianna 
Published: March 2019

Abstract
Adipose tissue contains an abundant population of mesenchymal stromal cells (= adipose stromal cells [ASC]) with multilineage differentiation, immunomodulatory and trophic potential promising for cell-based therapies. Although intensely investigated in pre- and clinical studies, little is known about the impact of donor characteristics on the viability of ASC. To correlate patient data to the quality of processed adipose tissue and to establish a first step towards a manufacturing process for cell therapy, we evaluated the effects of 2 harvesting systems (LipiVage, TTF-System) and donor characteristics on cell viability of nucleated cells in a cohort of 44 samples obtained from 17 donors.
The impact of donor-specific factors (localization, age, body-mass-index, chronic diseases, intake of drugs, nicotine consumption or disorders of the thyroid gland) and the harvesting system on nucleated cell (NC) counts and viability of processed lipoaspirates were statistically analyzed.
Increasing age has a significant positive influence on NC viability (P = 0.001). Donors with intake of thyroid hormones based on a hypothyroidism and suctioned with the LipiVage-System reached a significantly higher viability of NC (P = 0.038). No statistical difference was shown between the 2 harvesting-systems (P = 0.338) and the donor sites (P = 0.294).
We focused on a potential correlation between NC viability and donor characteristics. Based on the donor cohort investigated in this study, cells from elderly patients suctioned with the LipiVage-System and taking thyroid hormones yielded cells of higher viability, suggesting an improved quality for subsequent manufacturing procedures. Further investigations are necessary to understand and correlate this data to ASC in vitro characteristics.
Soft Tissue Reconstruction in Patients With Hemifacial Microsomia: A Systematic Review of the Literature
Authors: Sinclair Nicholas , Gharb Bahar Bassiri , Papay Francis , Rampazzo Antonio 
Published: March 2019

Introduction:
Hemifacial microsomia is the most common congenital disorder of the face after cleft lip and palate. While treatment of the bony abnormalities has been well documented, less attention has been paid to correction of the soft tissue deformity. This study aimed to systematically review the literature addressing the techniques utilized to correct the soft tissue deformity in hemifacial microsomia.

Materials and Methods:
A comprehensive review of peer-reviewed literature regarding the management of soft tissue reconstruction in patients with hemifacial microsomia was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. Odds ratio was used to assess differences in complication rates between reconstructions performed with free tissue transfer and fat grafting.

Results:
The literature search yielded 38 articles that were fully reviewed for data extraction. Articles were grouped into one of 5 reconstructive modalities—pedicled flap, microvascular free tissue transfer, structural fat grafting, alloplastic implant, and functional reconstruction. Microvascular free tissue transfer had a complication rate of 27.1%, while structural fat grafting had a complication rate of 4.2% (odds ratio 6.7, P
= 0.0003).

Conclusions:
Microvascular free tissue transfer likely provides greater volume than fat grafting at the cost of a higher complication rate. Mild to moderate soft tissue deformity can be corrected with serial fat grafting. However, severe soft tissue deformity is better corrected with microvascular free tissue transfer. When performing free tissue transfer, one should be prepared for recipient vessel anomalies. To provide adequate augmentation with isolated fat grafting, multiple sessions are likely required.
Polymorphous Low-Grade Adenocarcinoma: A Proposed Reconstruction Protocol Based on Past Surgical Experience
Authors: Gottlieb Jonathan B. , Joachim Michael , Leiser Yoav , Abdelraziq Murad , Abu El-Naaj Imad 
Published: March 2019

Background:To propose a reconstructive protocol based on surgical management experience of polymorphous low-grade adenocarcinoma (PLGA) and the location of the primary lesion.Methods:Data on the surgical management and the reconstructive technique of 14 histologically conformed patients with PLGA, all treated by the same surgeon, were analyzed and evaluated.Results:Mean follow-up period in our series was 6.2 years. Mean age at diagnosis was 55.5 years and female to male ratio was 2.2:1. The most common presenting sign was a nonpainful lump or mass in an intraoral location. Most patients were managed by wide local excision and reconstruction method varied from primary closure to the use of radial forearm graft. Recurrence appeared in one of the patients in this series, while 2 required further radiation therapy. A protocol for reconstruction of intraoral patients with PLGA is suggested based on our analysis.Conclusion:Surgical management is the gold standard for PLGA treatment. Neck dissection is recommended only in patients with presurgery fine-needle aspiration confirmed lymph node involvement. The reconstruction depends mainly on location and size of the primary lesion.
An Automatic Spatial Registration Method for Image-Guided Neurosurgery System
Authors: Fan Yifeng , Yao Xufeng , Hu Tingting , Xu Xiufang 
Published: March 2019

Objective:
This study aimed to investigate the feasibility of an automatic marker-free patient-to-image spatial registration method based on the 4-points congruent sets (4PCS) and iterative closest point (ICP) algorithm for the image-guided neurosurgery system (IGNS).

Methods:
A portable scanner was used to obtain the point cloud of the patient's entire head. The 4PCS algorithm, which is resilient to noise and outliers, automatically registered the point cloud in the patient space to the surface reconstructed from the patient's preoperative images in the image space without any assumptions about initial alignment. A variant of the ICP algorithm was then used to finish the fine registration. Two phantoms and 3 patients’ experiments were performed to demonstrate the effectiveness of the proposed method.

Results:
In the phantom experiments, the mean target registration error of 15 targets on the surface of the rigid and the elastic phantoms were 1.02 ± 0.18 mm and 1.27 ± 0.36 mm, respectively. In the clinical experiments, the mean target registration error of 7 targets on the first, second and third patient's head were 1.88 ± 0.19 mm, 1.84 ± 0.19 mm, and 1.89 ± 0.18 mm, respectively, which was sufficient to meet clinical requirements. The registration accuracy and registration time using the proposed method are better than that using the method based on manually coarse registration and automatic fine registration.

Conclusions:
It is feasible to use the automatic spatial registration method based on the 4PCS and ICP algorithm for the IGNS. Moreover, it can replace the spatial registration method based on manually selected anatomical landmarks combined with the automatic fine registration in the currently used IGNS.
Effectiveness of a Piezoelectric-Assisted Distraction Osteogenesis Procedure for the Treatment of Ankylosed Permanent Front Teeth
Authors: Ramaglia Luca , Cicciù Marco , Fiorentino Emilio , Saviano Raffaele , Blasi Andrea , Cervino Gabriele , Isola Gaetano 
Published: March 2019

Abstract
A common complication of tooth replantation after traumatic avulsion is tooth ankylosis causing dental malpositioning, partial loss of function, tipping of adjacent teeth and worsening of aesthetics. The aim of this study is to evaluate the effects of a repositioning procedure of such ankylosed permanent front teeth by a distraction osteogenesis procedure. Five patients (mean age 13.4 years), with an ankylosed permanent front tooth in the anterior area, were enrolled in the present study. After the pre-operatory orthodontic preparation, each selected site was treated with single-tooth dento-alveolar block osteotomy surgery performed with a piezoelectric surgery device with ultrasonic cuts on the buccal side. Subsequently, a custom distraction device, made by a resin splint and a sector expansion screw, was set in such a way it delivered a force with direction and sense towards the planned position of the tooth as well as the osteotomy's incision. After a latency period of 14 days, the distraction of the dento-alveolar block was started with a rate of distraction of 0.8 mm per day. The average shift obtained by the ankylosed teeth was 7.8 ± 0.75 mm (±SD), and the ankylosed tooth was regularly positioned into the occlusion in 20.4 ± 1.85 days (±SD), with a slight relapse (±0.5 mm) observed after 1 year. This study indicates that a therapeutic approach combining piezoelectric surgery and orthodontic therapy may be useful for the treatment of ankylosed permanent teeth in the frontal area with a long-term follow-up over 5 years.
Alternative Therapies to Fat Grafting in the Craniofacial Region
Authors: Yoo Jason J. , Casey Liann C. , Herweck Alexandra M. , Thaller Seth R. 
Published: March 2019

Abstract
Autologous fat grafting is a technique with various applications in the craniofacial region ranging from the treatment of wounds, scars, keloids, and soft tissue deformities. In this review, alternative therapies to fat grafting are discussed. These are composed of established therapies like silicone gel or sheeting, corticosteroids, cryotherapy, and laser therapy. Novel applications of negative pressure wound therapy, botulinum toxin A injection, and biologic agents are also reviewed.
Parents’ Knowledge, Attitude and Behaviour toward Cleft Lips and Cleft palate in Kencana Hospital, Serang, Banten
Authors: Soeselo Daniel Ardian , Suparman Alexandria Stephanie , Budi Agus Santoso 
Published: March 2019

Introduction:
Cleft lips (CL) and cleft palate (CP) are common congenital diseases caused by gene mutation in embriology development of the lips and mouth at 4 weeks of gestation. CL and CP can cause several problems such as difficulty in eating, speaking, abnormality in teeth and mouth development and ear iritation. Adequate treatment is needed to improve patients’ quality of life.

Material and Method:
This cross sectional study take samples purposively from all parents who joined in cleft charity surgery in Kencana Hospital, Serang, Banten on October 24th 2018. This study identify parents’ knowledge, attitude and behaviour towards CL and CP and analyzed the relationship of parents’ knowledge and attitude towards CL and CP. Statistical analysis used in this study is Fisher method.

Result:
Ten patients undergo labioplasty surgery, 1 patient undergo labioplasty revision, 5 patients undergo palatoplasty surgery and 10 patients undergo labioandpalatoplasty surgery. The majority of parents’ education background have income < 3,5 million a month 84.6% (22 people), do not have any social insurance 88.5% (23 people) and joined in because of they cannot pay for medical treatment 96,2% (25 people). 6.2% (25 people) have under knowledge, 69.2% (18 people) have good attitude and 84.6% (22 people) have good behaviour toward CL and CP. There is no significant relationship between parents’ knowledge and attitude toward CL and CP P value = 1,00 (P > 0,05).

Discussion:
Parent's under knowledge is caused by their low educational background and inaccurate information and education provided by medical professional. But, they had a good attitude and behaviour toward CL and CP because they had initiative to look for medical help and treat their children same as other normal one. Although they received inaccurate information and education about cleft disease, all parents looked for medical help and did what they were told by medical professionals.

Conclusion:
The majority of parents in this study have under knowledge about cleft lips and cleft palate but they are still looking for medical help to treat their children. This charity significantly helps parents whose children have cleft lips, with or without cleft palate, to get treated in that area.
Evaluation of the Accuracy of Virtual Planning in Orthognathic Surgery: A Morphometric Study
Authors: Zavattero Emanuele , Romano Michele , Gerbino Giovanni , Rossi Diego Sergio , Giannì Aldo Bruno , Ramieri Guglielmo , Baj Alessandro 
Published: March 2019

Background:
The purpose of this study was to prospectively test the accuracy of computer-aided orthognathic surgery comparing the virtual surgical planning with the three-dimensional (3D) outcome.

Methods:
Patients that underwent computer-assisted orthognathic surgery were retrospectively evaluated. The postoperative results were compared with the surgical plan, superimposing the postoperative computed tomography (CT) scan onto the virtual plan. Surface-based superimpositioning of the postoperative CT scan onto the 3D preoperative plan was carried out to visualize the discrepancy between preoperative virtual plan and postoperative 3D CT result.

Results:
A total of 17 consecutive patients that underwent two-jaw computer-assisted orthognathic surgery were enrolled in the study.
The average linear differences for selected points were <1 mm in 12 patients out of 17. In 5 patients out of 17, the average differences for selected points were <2 mm.

Conclusions:
An overall high degree of accuracy between the virtual plan and the postoperative result was found.
Fat Grafting in Orthognathic Surgery
Authors: Iyengar Rajiv J. , Gabrick Kyle , Bruckman Karl , Steinbacher Derek M. 
Published: March 2019

Background:
Fat grafting is widely utilized in craniofacial surgery. The authors describe a series of consecutive patients who underwent orthognathic surgery with fat grafting by the senior author and review relevant literature in the field; fat grafting technique is discussed in detail. The authors also highlight 3 patients to illustrate postoperative outcomes.

Methods:
A retrospective cohort of consecutive orthognathic surgery patients was reviewed. Age, sex, BMI, procedure, area of harvest, location of injection, donor site complications, and need for repeat fat grafting were analyzed. Inclusion criteria included history of orthognathic surgery and concomitant fat grafting performed by the senior author in 2015.

Results:
Fifty-three orthognathic surgery patients with concurrent fat grafting were reviewed. The cohort comprised 20 males (37.7%) and 33 females (62.3%). Thirty-three patients (62.3%) underwent Le Fort I operations either in conjunction with genioplasty and/or bilateral sagittal split osteotomies. Twenty-eight patients (52.8%) underwent second operations involving additional fat grafting. The majority of these patients (15/28, 53.6%) received additional fat grafting during ensuing rhinoplasty. There were no donor site complications (ie, infection, wound breakdown) recorded in the authors’ patient cohort. Amount of fat injected averaged 13.1 cc (range 5–25 cc). Follow-up generally occurred through the 1-year mark.

Conclusions:
Fat grafting is a proven technique to facilitate optimal postoperative wound-healing in orthognathic surgery. The senior author uses Telfa processing and the Coleman system to deliver the fat atraumatically. The authors’ cohort of consecutive patients corroborates the benefits of fat grafting in craniofacial surgery; the authors observe wound-healing benefits, enhanced aesthetic outcomes and an anti-inflammatory effect with this technique.
A Giant Cervical Lymphangioma
Authors: Demirag Evman Melis , Aydin Sedat 
Published: March 2019

Abstract
Cervical lymphangiomas are benign congenital malformations of lymphatic system usually seen in children under 2 years of age. It is rare in adults. They can be seen in any part of the body but the most common area in the neck region is posterior triangle. They usually present as asymptomatic masses. There are various ways of treatment, but the most common treatment modality is surgical resection. Here, the authors present a giant lymphangioma in the neck region of an adult who is treated with surgical resection without any complication.