bluuebunny/crossref_metadata_2025_split huggingface dataset:
The evidence-based new vista to wane the utilization of antimicrobials in UTIs
Authors: Kholy Amal A. El , Wahsh Engy A. , Batiha Gaber E. , Moustafa Hebatallah Ahmed Mohamed 
Published: November 2024

Abstract
Background
In recent years, antibiotic resistance rates have become a global concern for clinicians to combat the pathogenic bacteria associated with UTIs. The objective of this current paper is to explore the evidence-based use of natural products as an alternative strategy to reduce the recurrence rates among different UTI patient populations such as pregnant women, postmenopause women, and children.

Main body
Commonly used non-antimicrobial products to treat and prevent UTIs include vaginal estrogen, cranberry, probiotics, D-mannose, hyaluronic acid (HA), Chinese herbal medicine, and ascorbic acid. Literature supports the safety and effectiveness of utilizing these products in different UTI patients to a great extent. The strongest recommendation was given to the utilization of vaginal estrogen replacement therapy in postmenopausal females to prevent rUTI.

Conclusion
We believe our research is the first to provide evidence-based clinical practice guidelines and insight into UTI management using non-antimicrobial drugs in different populations. Our findings can guide future research on the reduction of antimicrobial misuse and preventing antimicrobial resistance.

Graphical Abstract
Video head impulse test (vHIT) unravels the hidden pathology in chronic vestibular deficit
Authors: Lasheen Reham Mamdouh , Kolkaila Enaas Ahmad , Elmehalawy Trandil Hassan , Mady Nashwa , Nada Nashwa 
Published: November 2024

Abstract
Background
The caloric test is persistently altered in chronic peripheral vestibular hypofunction (PVH). So, we cannot depend on it to measure the degree of compensation in chronic vestibulopathy patients who are still complaining. So our aim was to assess the utility of vHIT to discover the unrevealed pathology in those patients. Our study included 20 subjects with unilateral chronic PVH who were still complaining (study group) and 20 healthy volunteers (control group). Videonystagmography (VNG) and video head impulse test (vHIT) were applied to all the subjects.

Results
VNG and caloric test results showed compensation signs in the study group. The caloric test indicated unilateral weakness in the affected side. According to vHIT results, a comparison between the affected lateral canal, contralateral healthy lateral canal among the study group, Rt. lateral canal, and Lt. lateral canal among the control group revealed no significant difference (P = 0.789), while comparing anterior and posterior canals showed significant differences (P = 0.005, 0.025) respectively.

Conclusion
The caloric test assesses only the horizontal semicircular canal and it is persistently altered in unilateral chronic PVH. So, we cannot depend on it to measure the degree of compensation in chronic vestibulopathy patients who are still complaining nor to detect unrevealed pathology regarding ant or post semi-circular canal. So we can use the vHIT test to discover the unrevealed pathology in those patients.
Dasiglucagon in Children With Congenital Hyperinsulinism Up to 1 Year of Age: Results From a Randomized Clinical Trial
Authors: De Leon Diva D , Banerjee Indraneel , Kummer Sebastian , Birch Sune , Bøge Eva , Ivkovic Jelena , Kendall David M , Thornton Paul S 
Published: November 2024

Abstract

Context
Congenital hyperinsulinism (CHI) is a cause of persistent hypoglycemia in childhood with a considerable risk of lifelong neurological sequelae. Available pharmacological therapies are limited. Dasiglucagon is a glucagon analog for the treatment of hypoglycemia.

Objective
To assess the efficacy and safety of dasiglucagon in children with CHI up to 1 year of age.

Methods
This study included a randomized, crossover, double-blind, placebo-controlled part 1 and an open-label, single-arm part 2 at 4 centers in Germany, the United Kingdom, and the United States. Participants comprised children with CHI aged 7 days to 12 months who were dependent on IV glucose. In part 1, participants were randomized to dasiglucagon or placebo for 48 hours, then crossed over to the other treatment for 48 hours. In part 2, all participants received dasiglucagon for 21 days. The primary outcome was mean IV glucose infusion rate (GIR) in the last 12 hours of part 1.

Results
Between June 19, 2020, and February 9, 2022, 12 eligible participants were randomized to dasiglucagon–placebo (n = 7) or placebo–dasiglucagon (n = 5). The IV GIR was significantly reduced with dasiglucagon compared with placebo (least-squares mean 4.3 mg/kg/min [95% confidence interval [CI], 1.04 to 7.60 mg/kg/min] and 9.5 mg/kg/min [95% CI, 6.24 to 12.81 mg/kg/min], respectively; P = .004). The most frequent adverse events in both treatment groups were gastrointestinal, dermatological, and metabolism and nutritional disorders.

Conclusion
In infants with CHI, dasiglucagon significantly reduced the amount of IV glucose needed to maintain euglycemia compared with placebo. Dasiglucagon represents a promising treatment for the management of CHI.
The Politics of Alien Listening
Authors: Gallope Michael 
Published: November 2024

Abstract
Daniel Chua and Alexander Rehding's book Alien Listening: Voyager's Golden Record and Music from Earth (2021) offers a deep philosophical discussion of NASA's Golden Record that had been attached to the side of its 1977 Voyager probe. The Golden Record was an album of sounds from around the world that was sent in the hope that an alien listener might be able to hear examples of music and language from planet Earth. Chua and Rehding's book uses NASA's Golden Record as a portal through which to imagine a new philosophy of music and listening based in vibration, inconsistency, generosity toward the unknown, and unconditional inclusion. This review analyzes the philosophical content of their book and poses questions about the underlying epistemological and political complexity of their ethical injunction.
David Graeber's Anthropology of Human Possibilities
Authors: Çubukçu Ayça 
Published: November 2024

Abstract
This essay offers a close reading of David Graeber's posthumously published magnum opus The Dawn of Everything: A New History of Humanity (2021), which he co-authored with David Wengrow. The essay engages critically with the concepts of “humanity” and “freedom” that The Dawn of Everything advances. Highlighting how Graeber's Fragments of an Anarchist Anthropology (2004) foreshadows The Dawn of Everything in the kind of radical social theory both books advance, the essay proposes that we treat Graeber's scholarship as an anthropology of human possibilities.
Analysis of Current Evidence in the Endovascular Treatment of Intracranial Aneurysms: A Systematic Review and Proposal for a Reporting Guideline to Enhance Reproducibility and Comparability of Surgical and Clinical Outcomes
Authors: Ferreira Marcio Yuri , Batista Sávio , Camerotte Raphael , Vilardo Marina , Nogueira Bernardo Vieira , Hong Anthony , Santos Ana B. , Günkan Ahmet , Bocanegra-Becerra Jhon E. , Ribeiro Filipe Virgilio , Perdigão Vinicius , Cardoso Leonardo Januário Campos , Bertani Raphael , Ferreira Christian , Langer David J. , Serulle Yafell 
Published: November 2024

BACKGROUND AND OBJECTIVES:
Endovascular therapy (EVT) has recently become the most widely used treatment method for intracranial aneurysms (IAs). However, the literature on this topic is heterogeneous, with studies assessing and reporting surgical and clinical outcomes in different ways, lacking standardization. We aimed to evaluate the quality of these studies and propose a reporting guideline focusing on essential elements to ensure reproducibility and comparability.

METHODS:
After Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, we searched Medline, Embase, Cochrane Library, and Web of Science databases. Eligible studies were observational or randomized, reported clinical and/or surgical outcomes of EVTs for IAs, included over 200 patients, and were published in English between January 1, 2022, and January 1, 2024. Studies were assessed focusing on key domains: (1) reporting on the baseline characteristics of the patient sample, (2) assessment and reporting on imaging methods and aneurysm characteristics, (3) reporting on pivotal concepts definitions, (4) reporting on operator(s) and staff characteristics, (5) reporting on anesthetic protocol, (6) reporting on antiaggregant and anticoagulation therapy, (7) reporting on surgical details, (8) assessing and reporting clinical and surgical outcomes, and (9) reporting retreatment details.

RESULTS:
Thirty-nine studies comprising 79 604 patients were included. Our assessment revealed substantial gaps in the literature on EVTs for IAs, including deficiencies across all domains. An EndoIAs Reporting Guideline was developed, consisting of 74 items distributed across 10 domains, focusing on key surgical and clinical outcomes.

CONCLUSION:
Substantial deficiencies were identified in data collection and outcomes reporting in the available literature on EVT for IAs, thereby impeding comparability and reproducibility and hindering the building of cumulative evidence. The aim of the proposed EndoIAs Reporting Guideline was to address these fundamental aspects and has the potential to enhance the reproducibility and comparability of future studies, thereby fostering the building of cumulative and reliable evidence of EVT for IAs.
ANALYSIS AND MINIMIZATION OF THE RISKS OF HARMFUL DEPENDENCIES IN THE PROCESS OF CONTINUOUS INTEGRATION AND IMPLEMENTATION OF SOFTWARE CODE
Authors: Alekseev Danil N. , Khamitov Renat M. 
Published: November 2024

Continuous integration and continuous deployment (CI/CD) processes have become essential elements of modern software development, enabling automation and optimization of work processes. However, these processes come with risks associated with vulnerabilities in the dependency chain, which can lead to serious consequences such as unauthorized access and data leakage. The article discusses the need to implement reliable mechanisms for detecting and mitigating dependency risks to improve the reliability of CI/CD.
The main risk in CI/CD processes is the exploitation of malicious dependencies used during the software build and deployment process. The main types of attacks include dependency confusion, dependency hijacking, and typo cybersquatting. To prevent these threats, various protection methods are proposed, such as controlling access to private packages, using automated tools for monitoring and checking dependencies, and implementing machine learning systems to detect suspicious packages. These measures are aimed at ensuring the integrity and security of software products, minimizing the risks associated with dependencies in CI/CD.
Purpose. Analyze dependency chain attacks and identify effective risk management methods to ensure high security of continuous integration and deployment processes to improve software development practices by identifying and eliminating potential vulnerabilities and stability issues, which provides safer and more reliable software delivery pipelines, reducing the likelihood of failures and disruptions in production environments.
Methodology. This work includes the results of both international and local scientific research. To identify the relationships and obtain original conclusions, the author uses theoretical research methods, paying special attention to the search and analysis of information. The authors apply theoretical research methods related to the search and analysis of information to identify connections and obtain unique conclusions.
Results. The analysis of the risks of malicious dependencies in the process of continuous integration and implementation of the program code is carried out. Methods have been identified to minimize the risks of dependency abuse, the need to implement multi-level security measures, including automated monitoring and analysis tools, strict access control to repositories and the use of cryptographic methods to verify the integrity of packages. In addition, regular audits and employee training help maintain a high level of security and awareness of potential threats.
Practical implications. It is advisable to apply the results obtained in the field of DevOps development in order to optimize the application development and release process by eliminating a known bottleneck: minimizing the risks of malicious dependencies in the process of continuous integration.
Revenue Maximization Under Unknown Private Values with Nonobligatory Inspection
Authors: Alaei Saeed , Makhdoumi Ali , Malekian Azarakhsh 
Published: November 2024

Rethinking Informational Assumptions in Mechanism Design Mechanism design has proven to be very effective is soliciting buyers’ incentives and finding the optimal way of allocating scares resources. A common assumption in classic mechanism design, however, is that buyers have full information about their values. Motivated by application in e-commerce, Alaei et al. (2024) consider settings without this assumption and finds the optimal selling mechanism for them.
A militância de José Rodrigues Vieira Netto na luta contra a ditadura militar (1964-1985) e pela redemocratização do Brasil
Authors: Costa Regis Clemente da 
Published: November 2024

Esse artigo analisa a trajetória de José Rodrigues Vieira Netto na luta contra a ditadura militar (1964-185) e pela redemocratização do Brasil e evidencia sua atuação na organização do projeto societário comunista no Paraná. Insere-se na História Intelectual e se embasa no conceito gramsciano de intelectual orgânico. Apoia-se nas fontes dos arquivos do DOPS-Paraná, da Plataforma ‘Brasil: Nunca Mais’ Digital e de livros memorialistas. A militância de Vieira Netto implicou em consequências na ditadura militar (1964-1985), como a prisão, a tortura, ameaça de morte e a aposentadoria compulsória como professor na UFPR. Vieira Netto manteve suas convicções políticas e sua concepção práxica ao longo de sua trajetória, reafirmando, em seu testamento, sua atuação na luta contra a ditadura e a defesa da redemocratização do país.
Participação feminina na renovação de espaços urbanos no Brasil: uma análise do ODS 11 da Agenda 2030 sob a perspectiva de gênero
Authors: Passos de Freitas Vladimir , Flugel Assad Sandra Mara , Deretti Martins Luiza 
Published: November 2024

Objetivo: Este artigo examina a renovação dos espaços urbanos proposta no ODS 11 da Agenda 2030 da ONU com uma lente de gênero na realidade brasileira. Método: Para alcançar o seu intento, utiliza o método hipotético-dedutivo e realiza uma pesquisa exploratória-analítica. Primeiramente, identifica as responsabilidades pelo cumprimento das metas estabelecidas na Agenda 2030. Reflete sobre o ODS 11 e no modo como as mulheres são particularmente impactadas pelos problemas relacionados aos espaços urbanos. Investiga possibilidades de efetiva participação feminina na revitalização das cidades e na recuperação de ambientes degradados, e correlaciona a concretização das metas do ODS 11 ao atingimento das metas do ODS 5. Resultados: Obteve-se que o Brasil integrou seu sistema jurídico com normas de proteção ambiental e desenvolveu indicadores para acompanhar a implementação da Agenda 2030. Inferiu-se a interdisciplinaridade dos objetivos da Agenda 2030, estando os indicadores e as metas dos objetivos 11 e 5 interligados no que toca a relação existente entre o gênero e o meio ambiente. Anotou-se a importância da participação feminina para a organização do espaço das cidades e a existência de iniciativas correlatas no Brasil. Considerações finais: A abordagem dos espaços urbanos deve adotar uma perspectiva multidisciplinar, conjugada à ideia de gênero.
Design and fabrication of an encapsulated broadband infrared wire-grid polarizer for an infrared imaging system
Authors: Lu Fanfan , Li Angran , Liu Ying , Deng Loulou , Yang Ying , Chen Mingce , He Wei , Qiu Keqiang , Hong Yilin 
Published: November 2024

Wire-grid polarizers (WGPs) operating in the long-wave infrared (LWIR) bands are widely
used in infrared polarimetric imaging systems. The increasing
complexity of modern imaging environments presents additional
challenges for these polarizers. This study introduces a design method
and fabrication process for an encapsulated WGP. We investigate the
fabrication process of an Au/Si bilayer wire grid including
holographic interference lithography, reactive etching, and the
deposition of zinc sulfide (ZnS) film onto the grating structure. This
film not only protects the underlying metal wire-grid structures but
also enhances the transmittance as anti-reflective coating (ARC).
Experimental results indicate that the average transmittance of
transverse magnetic (TTM) polarized light exceeds 70% at
7–12.1 µm, with the TTM averaging over 80% between
7.6 µm and 10.4 µm. This design is particularly
effective in suppressing the resonance absorption peaks that typically
occur for the silicon element around 9 µm. The average
extinction ratio (ER) exceeds 30 dB across the LWIR, reaching
up to 35 dB within the range of 7–10.6 µm. The
encapsulated polarizers are desired to improve the durability of the
wire grid by sealing the metal wire-grid structures while increasing
both TTM and ER.
Fetal and neonatal outcomes in syphilis infected pregnant women in Reunion Island: An observational retrospective multicentric study
Authors: Cramez Camille , Lafont Marine , Boumahni Brahim , Boukerrou Malik , Tran Phuong Lien 
Published: November 2024

Objectives
To evaluate the fetal and neonatal morbidity and mortality in pregnant women with syphilis during their pregnancy in Reunion Island, population benefiting from early and well-conducted screening and treatment.

Methods
This is a retrospective observational study conducted in the four Reunion hospital centers between 2017 and 2022. The included patients were all pregnant patients with a biologically proven syphilitic infection and having given birth in one of the four centers mentioned.

Results
108 patients were included, with 113 fetuses and newborns. Fetal mortality rate was 2.7%, neonatal mortality rate was 1.8% and congenital syphilis rate was 7%. Despite 37% of patients with a vulnerable psycho-social context, 72% were screened early, 13% in the second trimester, 44% had received optimal treatment and 48% optimal syphilis monitoring. We found 43% of obstetric complications with 12% of IUGR and 4.6% of pre-eclampsia. 21% of newborns were preterm and 17% small for gestational age. There was a significant trend between psycho-social vulnerability and congenital syphilis.

Conclusions
Fetal and neonatal morbidity and mortality is low in our Reunion Island population where screening and treatment of syphilis are early and well conducted, although a vulnerable group of patients remain who require specific antenatal care.
Histology-specific long-term oncologic outcomes in patients with epithelial ovarian cancer who underwent complete tumor resection: The implication of occult seeds after initial surgery
Authors: Mogi Kazumasa , Yoshihara Masato , Emoto Ryo , Miyamoto Emiri , Fujimoto Hiroki , Uno Kaname , Tano Sho , Iyoshi Shohei , Kitami Kazuhisa , Yoshikawa Nobuhisa , Matsui Shigeyuki , Kajiyama Hiroaki 
Published: November 2024

Objective
Assessing the histology-specific prognosis of epithelial ovarian cancer (OvCa) is clinically challenging, especially in a patient population with a favorable prognosis. This study investigated the histology-specific long-term oncologic outcomes in OvCa patients who underwent complete tumor resection using a large-scale patient cohort form multiple institutions under a central pathological review system.

Methods
A regional multi-institutional study was conducted from 1986 to 2019. Of the 4,898 patients with ovarian tumors enrolled, 1,175 patients who underwent complete tumor resection were classified into three classes based on clinically important prognostic factors: stage, cytology, ascites volume. For each class category, the effect of histology types on recurrence-free survival, the site of recurrence, and post-recurrence survival was evaluated.

Results
Recurrence-free survival varied significantly across different histologies (P < 0.001). The risk of recurrence was higher in serous carcinoma compare to other histologies (P < 0.001). The site of tumor recurrence varied by the histology type. Multinominal logistic regression analysis revealed that mucinous histology had a significantly higher likelihood of developing recurrent tumors at distant sites from the peritoneum compared to other histologies (P = 0.002). Conversely, serous histology was associated with better post-recurrence survival (Log-rank P < 0.001).

Conclusions
Long-term oncologic outcomes significantly differ by histology type in OvCa patients who have undergone complete tumor resection at the initial surgery. A careful evaluation of the clinical background is necessary for these patients, and further clinical research into individualized treatment approaches is essential.
Is transcutaneous auricular vagus nerve stimulation effective and safe for primary insomnia? A PRISMA-compliant protocol for a systematic review and meta-analysis
Authors: Yang Ting , Cai Yunhuo , Li Xingling , Fang Lianqiang , Hu Hantong 
Published: November 2024

Background
Insomnia is a highly prevalent sleep disorder with substantial impacts on health and quality of life. Current treatment options have certain limitations, highlighting the need for novel therapeutic approaches. Transcutaneous auricular vagus nerve stimulation (ta-VNS) is gaining recognition as a promising non-invasive neuromodulation technique for treating insomnia, but its efficacy has not been systematically evaluated. Therefore, this protocol outlines the framework for a systematic review and meta-analysis designed to comprehensively assess the effectiveness and safety of ta-VNS in treating primary insomnia.

Methods
A thorough literature search will be carried out in Embase, PubMed, the Cochrane Library, PsycINFO, AMED, PEDro, Wangfang database, Chinese National Knowledge Infrastructure, and Chinese BioMedical Literature Database, covering publications from their inception until December 31, 2024. Randomized controlled trials evaluating ta-VNS for primary insomnia in adults will be included. Two independent reviewers will screen studies, gather data, and evaluate the risk of bias based on the Cochrane RoB 2.0 tool. Meta-analyses will be conducted where appropriate, and the quality of evidence will be evaluated using GRADE. Subgroup and sensitivity analyses are planned.

Discussion
This systematic review and meta-analysis will deliver a thorough synthesis of existing evidence regarding the efficacy and safety of ta-VNS for insomnia, potentially informing clinical practice and future research directions.

Trial registration
PROSPERO registration number: CRD42024529039.