bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Cancer Burden Attributable to Dietary Risks: Trends, Regional Disparities, and Future Projections (1990-2050)
Authors: Liang Jinghao , Lin Yijian , Huang Zishan , Ni Jingchun , Lin Hongmiao , Cai Yiwen , Qi Jihao , Yao Liangyi , Yang Luoyao , Lin Dianhan , Guo Zhihua , Yin Weiqiang , He Jianxing 
Published: December 2024

AbstractCancer remains a leading global cause of death, with its burden increasingly shaped by demographic shifts and dietary factors. This study utilized the Global Burden of Disease (GBD) 2021 database to evaluate cancer burdens attributable to dietary risks from 1990 to 2021, accounting for differences by age, gender, region, and socioeconomic level, and projected trends through 2050 using a Bayesian Age-Period-Cohort model. The global disability-adjusted life years (DALYs) attributable to dietary risks declined from 302.48 to 189.62 per 100,000 population (AAPC: −1.49%) over three decades, yet disparities remain prominent across Socio-Demographic Index (SDI) regions. High-SDI countries, such as Luxembourg, achieved substantial reductions, while low-SDI nations like Lesotho and Zimbabwe experienced rising burdens, driven by inadequate dietary quality and limited health resources. Key dietary risks, including low intake of whole grains, milk, and red meat, demonstrated improvement in high-income countries but worsening trends in many low- and middle-income regions. Projections suggest a continued global decline in cancer burden attributable to dietary factors by 2050, with high-income regions benefiting most, while Latin America, the Caribbean, North Africa, and the Middle East may experience slower progress or transient increases. Additionally, the burden of poor dietary practices is expected to rise sharply among individuals aged 75 years and older, underscoring the compounding effects of aging populations. These findings highlight the urgent need for culturally tailored dietary interventions and evidence-based policies to address disparities, reduce cancer burdens, and improve outcomes for vulnerable populations globally.
Impact of a transient neonatal visual deprivation on the development of the ventral occipito-temporal cortex in humans
Authors: Mattioni Stefania , Rezk Mohamed , Gao Xiaoqing , Nam Junghyun , Liu Zhong-Xu , Gau Remi , Goffaux Valérie , Constantino Andrea I. , de Beeck Hans Op , Lewis Terri , Maurer Daphne , Collignon Olivier 
Published: December 2024

AbstractHow does experience shape the development of visual brain regions? We demonstrate that a transient period of visual deprivation early in life in humans leads to permanent alteration in the function of the early visual cortex (EVC), while leaving the categorical coding of downstream ventral occipito-temporal cortex (VOTC) mostly unaffected. We used fMRI to characterize the brain response to five categories (faces, bodies, objects, buildings and words) in a rare group of cataract-reversal individuals who experienced a transient period of blindness early in life, and in matched participants with typical visual development. We show that the encoding of low-level visual properties is impaired in EVC in cataract-reversal participants, while the categorical response in the VOTC is preserved. When altering the visual properties of our stimuli to mimic in controls the deficit of EVC response of the cataract, we observe a cascading alteration of the categorical coding from EVC to VOTC that is not observed in the cataract-reversal group. Our results show that a typical visual categorical organization develops in VOTC despite a period of visual deprivation early in life and in the presence of impaired processing in EVC. A deep neural network exposed to a visual diet that emulates the experience of our participants reproduced our brain observations within an artificial system. These findings emphasize how specific visual regions are differently affected by a period of visual deprivation early in life, with information encoded in EVC being permanently affected, while the categorical coding in VOTC shows resilience to deprivation.
Emotion processing in mothers with bonding disorder during the first year postpartum: Results of an adapted fMRI emotional GoNoGo Task
Authors: Eckstein Monika , Krauch Marlene , Brenner Ines , Zietlow Anna-Lena , Ditzen Beate 
Published: December 2024

AbstractMaternal bonding refers to the unique emotional connection between a mother and her baby that gradually develops during the pre- and postpartum period. However, 3-24% of women report bonding disorders (BD), often accompanied by constraints for the mother-infant relationship with consequences for child development. The underlying neural patterns are not clarified yet. Our present study investigates the neural and behavioral patterns that underlie the processing of emotional infant stimuli over the 1 year postpartum. Mothers with and without BD (N = 45) completed an adapted (newly developed) Emotional Infant GoNoGo Task while fMRI scanning at 3, 6 and 12 months postpartum. Our results show that response inhibition towards emotional infant faces elicits stronger results than towards adult faces in all mothers. While behavioral performance in BD is impaired, the neural responses to emotional infant faces as compared to neutral faces are increased at 3 months postpartum in limbic structures such as the anterior cingulate and insula, as well as nucleus caudatus. At 6 and 12 months behavioral reactions assimilate in BD to those of healthy controls, while differences in neural reactions between BD and healthy controls increase at 6 months and decrease again at 12 months. These effects are independent of depressive symptoms. Our findings point to an experience-based adaptive process of emotion processing and responses to infants’ affect during the first year postpartum as a specific characteristic of clinical bonding disorder and thus might point to potential or future therapeutic interventions targeting emotion processing and regulation in mothers with BD.Key Findings⍰ We present an adapted version of an Emotional GoNoGo Task for fMRI with infant stimuli: Behavioral inhibition towards emotional infant faces leads to increased activity in emotion regulation networks compared to adult faces in women during the 1styear postpartum.⍰ Women with postpartum bonding disorder (BD) show increased neural reactions (ACC, NCl Caudate, Insula) towards emotional baby faces (not adult faces, irrespectively of instructed inhibition and of valence) compared to a healthy control group (CG) at 3 months postpartum.⍰ On a behavioural level, women with BD show increased reaction times to positive emotional adult faces and higher error rates during the inhibition of reaction towards emotional baby faces at 3 months.⍰ Differences in neural reactions to emotional baby faces between BD and CG increase at 6 months and decrease again at 12 months, while behavioral reactions in BD assimilate to those of CG
Network-based drug repurposing for psychiatric disorders using single-cell genomics
Authors: Gupta Chirag , Kalafut Noah Cohen , Clarke Declan , Choi Jerome J. , Arachchilage Kalpana Hanthanan , Khullar Saniya , Xia Yan , Zhou Xiao , Gerstein Mark , Wang Daifeng 
Published: December 2024

AbstractNeuropsychiatric disorders lack effective treatments due to a limited understanding of underlying cellular and molecular mechanisms. To address this, we integrated population-scale single-cell genomics data and analyzed cell-type-level gene regulatory networks across schizophrenia, bipolar disorder, and autism (23 cell classes/subclasses). Our analysis revealed potential druggable transcription factors co-regulating known risk genes that converge into cell-type-specific co-regulated modules. We applied graph neural networks on those modules to prioritize novel risk genes and leveraged them in a network-based drug repurposing framework to identify 220 drug molecules with the potential for targeting specific cell types. We found evidence for 37 of these drugs in reversing disorder-associated transcriptional phenotypes. Additionally, we discovered 335 drug-associated cell-type eQTLs, revealing genetic variation’s influence on drug target expression at the cell-type level. Our results provide a single-cell network medicine resource that provides mechanistic insights for advancing treatment options for neuropsychiatric disorders.
Effects of Vascular Endothelial Growth Factor Family on Macular Pucker:cis-Mendelian Randomization and Colocalization Analyses
Authors: Gao Qi , Guo Jinglong 
Published: December 2024

AbstractBackgroundVascular endothelial growth factor (VEGF) family and its receptors (VEGFR) could be implicated in macular pucker (MP) pathogenesis. We usedcis-Mendelian randomization (cis-MR) and Bayesian colocalization with summary-level genome-wide association study (GWAS) data to explore causal relationships.MethodsGenetic variants associated with soluble VEGFR2 (sVEGFR2), sVEGFR3, VEGF-A, VEGF-C, or VEGF-D levels were selected from a GWAS of protein quantitative trait loci with 35,559 Icelanders. MP GWAS (3,974 cases, 376,650 controls) was sourced from the FinnGen. We employedcis-MR using invariance-weighted median, supplemented by other methods. Bayesian colocalization validatedcis-MR findings. Pleiotropy, reverse causality, and heterogeneity were assessed.FindingsCis-MR suggested that genetically predicted higher levels of sVEGFR2 were associated with reduced MP risk (Odds ratio (OR) 0.82, 95% confidence interval (CI) 0.75-0.89, P=9.20 × 10-6). Colocalization supported shared genetic variants in theVEGFR2gene region between sVEGFR2 and MP (posterior probability of hypothesis 4 (PPH4) =0.94), reinforcing sVEGFR2’s protective role in MP. Althoughcis-MR suggested an inverse relationship between sVEGFR3 levels and MP risk (OR 0.71, 95% CI 0.57-0.89, P=2.64 × 10-3), colocalization analysis did not confirm direct causality (PPH4=0.03). VEGF-A, VEGF-C and VEGF-D levels were not associated with MP risk in MR analyses. No evidence of pleiotropy, reverse causality, and heterogeneity was found across our MR analyses.InterpretationOur study suggested that sVEGFR2 has causally protective effects against MP and could serve as a potential drug target. Further research is necessary to elucidate its protective mechanisms and validate its translational implications.
Efficacy of Melflufen in Patients with Relapsed/Refractory Multiple Myeloma and Mutated or DeletedTP53
Authors: Acs Klara , Miettinen Juho J. , Sergeev Philipp , Heckel Tobias , Diao Yumei , Witt-Mulder Kristina , Thureson Marcus , Bischler Thorsten , Huppunen Maiju-Emilia , Obermüller Jakob , Munawar Umair , Slipicevic Ana , Bargou Ralf C. , Lehmann Fredrik , Gelius Stefan Svensson , Norin Stefan , Schjesvold Fredrik , Sonneveld Pieter , Stühmer Thorsten , Heckman Caroline A. 
Published: December 2024

ABSTRACTBackgroundPatients with relapsed/refractory multiple myeloma (RRMM) and high-risk genetic abnormalities such as del(17p) andTP53mutation have poor response to standard therapies and shorter survival compared to patients without these aberrations. Here, we investigated the activity and mechanism of action of peptide-drug conjugate melphalan flufenamide (melflufen) inTP53wild type (TP53wt) and mutant (TP53mut) myeloma models and assessed the efficacy of melflufen in patients with del(17p) and/orTP53mutation.MethodsWe evaluated melflufen activityex vivoin 24 myeloma bone marrow (BM) samples and explored indicators of response from single cell RNA sequencing (scRNAseq) profiles. The efficacy of melflufenvs.control treatments was further investigated inTP53−/−and parentalTP53wt myeloma cell lines. DNA damage, apoptosis kinetics, mitochondrial function, plus transcriptomic and metabolic data were analyzed to understand the mechanisms responsible for melflufen activity in the absence of p53. Patient outcome data from the OCEAN phase III clinical trial (NCT03151811), which investigated the clinical activity of melflufen in RRMM, were statistically analyzed to assess the impact of del(17p) andTP53mutation on clinical response.ResultsBM plasma cell (PC) response to melflufen was independent ofTP53mutation status, with melflufen active in del(17p),TP53mut, andTP53wt samples. Differential analysis of scRNAseq data demonstrated that melflufen sensitive PCs had lower expression of p53 target genes and higher expression of genes associated with DNA damage repair and cell cycle checkpoints. Analysis ofTP53−/−andTP53wt cell lines showed superior efficacy of melflufen in comparison to melphalan or cyclophosphamide. In the presence and absence of functional p53, melflufen robustly induced apoptosis, DNA damage, and mitochondrial dysfunction. InTP53−/−cells, melflufen treatment led to distinct changes in expression of genes associated with cell cycle checkpoint and apoptosis, which were not observed with melphalan treatment. Notably, post-hoc analysis of the OCEAN trial del(17p) patient population demonstrated favorable progression free survival in the del(17p) subgroup treated with melflufen plus dexamethasone compared to the pomalidomide plus dexamethasone arm.ConclusionsOur insights into the molecular mechanisms of melflufen activity inTP53mut myeloma support its clinical efficacy and application in the del(17p) andTP53mut patient population.Trial registrationNCT03151811, registration 2017-05-09.
Axions in Andromeda: Searching for minicluster-neutron star encounters with the Green Bank Telescope
Authors: Walters Liam , Shroyer Jordan E. , Edenton Madeleine , Agrawal Prakamya , Johnson Bradley , Kavanagh Bradley J. , Marsh David J. E. , Visinelli Luca 
Published: December 2024

The QCD axion and axionlike particles are compelling candidates for galactic dark matter. Theoretically, axions can convert into photons in the presence of a strong external magnetic field, which means it is possible to search for them experimentally. One approach is to use radio telescopes with high-resolution spectrometers to look for axion-photon conversion in the magnetospheres of neutron stars. In this paper, we describe the results obtained using a novel approach where we used the Green Bank Telescope (GBT) to search for radio transients produced by collisions between neutron stars and dark matter clumps known as axion miniclusters. We used the versatile GBT astronomical spectrometer and the X-band receiver (8–10 GHz) to observe the core of Andromeda. Our measurements are sensitive to axions with masses between 33 and 42  μeV with Δma=3.8×10−4  μeV. This paper gives a description of the search method we developed, including observation and analysis strategies. Given our analysis algorithm choices and the instrument sensitivity (∼2  mJy in each spectral channel), we did not find any candidate signals greater than 5σ. We are currently implementing this search method in other spectral bands.

Published by the American Physical Society
2024
Do religious values mitigate the effect of formal corporate governance rules on earnings management in Islamic countries? Evidence from Jordan
Authors: Almarayeh Taha , Aibar-Guzmán Beatriz 
Published: December 2024

Purpose
This study aims to assess the board of directors’ effectiveness in curbing earnings management (EM) in Jordan, a country where Islamic religious values strongly influence corporate practices.

Design/methodology/approach
Using a sample of 51 Amman Stock Exchange-listed firms from 2012 to 2022, generalised least squares regression is used to examine the association between board characteristics and EM.

Findings
Most board characteristics do not significantly affect EM. Interestingly, board activity is significantly and positively associated with EM, suggesting that the board’s monitoring function has been relegated to a secondary role.

Research limitations/implications
Formal corporate governance mechanisms may prove ineffective, as their effectiveness in limiting EM is undermined by informal rules.

Practical implications
Regulators should adapt corporate governance rules to the context in which they are embedded. Greater attention to religious dynamics could improve board oversight effectiveness.

Originality/value
This study provides a new perspective to analyse the relationship between corporate governance and EM. To the best of the authors’ knowledge, this is among the first studies to explore this issue within the context of Islamic countries.
“Scaling up Mariam Special Venture”: nutritious products towards base of pyramid consumers in developing economy
Authors: Pipim Kwame Ntim 
Published: December 2024

Learning outcomes
After completion of the case study, students will have the ability to identify and apply various distribution strategies in the low-income market segment, to identify how last mile distribution is organized and executed in unconventional market situation and to identify and apply the 4Ps to support low-income market in last mile situations.

Case overview/synopsis
Mariam Atinga, the founder and owner of Mariam Special, was a native of Garu in the Upper East region. Mariam Special had specialized in the processing of freshly grown sorghum in the community into sorghum drink alongside some other natural spice additives. The drink was popularly called and known in the Garu community as “Zomkom”. Although there were other women who also processed and sold the drink in the community, the competitive advantage with Mariam Special was on the hygiene and innovative way it was prepared. She was also outward looking and had already made some attempt at expanding her business and passion beyond the community/district and into the villages. This was where her passion and interest caught the attention of a non-governmental organization (NGO) with interest in supporting low incomes in last mile situations. Atinga’s main interest and that of the NGO was hence to develop a route-to-market and associated strategic marketing approaches to reach this type of market or audience in Garu environs in the Upper East region of Ghana.

Complexity academic level
This case study is suitable for undergraduate students.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS8: Marketing.
When and why is kinship important? Reducing turnover intention with kinship employee engagement
Authors: Pariyanti Eka , Adawiyah Wiwiek Rabiatul , Wulandari Siti Zulaikha 
Published: December 2024

Purpose
The main objective of this study is to assess kinship employee engagement as a mediating variable in the relationship between person–organization–fit (P-O Fit) and person–job–fit with turnover intention.

Design/methodology/approach
This research was conducted at creative industry micro, small and medium enterprises (MSME) in Yogyakarta, Indonesia. The number of respondents was 331 MSME employees. The distribution of questionnaires was carried out using offline and online systems through direct questions and Google forms. The data analysis tool used was structural equation modelling.

Findings
The findings of this study revealed that kinship employee engagement is proven to mediate the relationship between P-O-fit and P-J-fit on turnover intention.

Research limitations/implications
This research provides a new perspective on social exchanges, namely, exchanges that are intangible based on the relationship between employees, leaders and owners of micro and small medium enterprises (MSMEs) in the form of kinship employee engagement. Employees who feel P-O Fit and P-J fit with their organizations will exhibit positive behavior in the form of kinship employee engagement.

Practical implications
The first practical implication is that MSME superiors/owners must pay more attention to P-O fit; one way to do this is to assess P-O fit at the recruitment and selection stage. This may be useful for organizations that hire and retain employees whose goals and values closely match those of the organization. With regard to the P-J fit relationship, and turnover intention, which turns out to have a negative relationship, this finding has implications for the formulation of policies that should not only focus on increasing the knowledge, skills and abilities of employees but also on fulfilling their wishes. For example, providing employees with training, self-development opportunities, flexible working hours and competitive salaries will strengthen their level of compatibility with their jobs, which in turn will reduce the willingness of employees to leave their jobs.

Social implications
In social practice, kinship employee engagement can be applied to MSMEs. When MSME owners have limited funds, facilities, etc., to bind employees, they can apply kinship to employees so that they are more attached to MSMEs.

Originality/value
This study is among the first to introduce a new construct (kinship employee engagement) which is an extension of the engagement construct that is more specific and follows the MSME context, and is the first study to propose kinship employee engagement as a mediating variable in the relationship between P-O-fit and P-J-fit on turnover intention.
Service quality and customer loyalty in Ghana’s auto detailing service industry
Authors: Allan Michael Mba , Alomenu Clemence , Anabila Peter 
Published: December 2024

PurposeThe study investigates service quality in developing customer loyalty in Ghana’s auto detailing industry. The study also examines how customer satisfaction and service innovation indirectly and positively influence the relationship between service quality and customer loyalty.Design/methodology/approachA sample of 318 respondents, drawn from a convenience sampling method, was utilised for the analysis. Partial Least Squares (PLS) of Structural Equation Modelling (SEM) technique was used to analyse the data to obtain results.FindingsThe study established a significant positive relationship between the tangibility dimension of service quality and customer loyalty; however, this influence is indirect through the mediation effect of customer satisfaction between service innovation and customer loyalty.Practical implicationsThe study provides a useful guide for policy formulation and implementation by managers of auto detailing services to enhance customer loyalty as a basis of sustainable business performance.Originality/valueThe study is the first of its kind to investigate the role of service quality and customer loyalty being mediated by service innovation and customer satisfaction in the context of Ghana’s auto detailing industry.
Damage assessments of designed sandwich cores against an idealized impact loading of ship accidents: experiment-based validated nonlinear finite element approach
Authors: Saputra Reza Kurniawan , Fhandy Brilliant Aditya , Prabowo Aditya Rio , Do Quang Thang , Santoso Budi , Muhayat Nurul 
Published: December 2024

PurposeThe high rate of ship casualties demands serious attention. Earlier studies have yet to integrate several scenarios in an experiment. This research aims to determine damage to a ship's hull that is assumed to have been stranded due to being hit by a rock under the sea.Design/methodology/approachThis scenario was analyzed by conducting a penetration test simulation using the ANSYS LS DYNA. Modeling was carried out with core, speed, indenter shape and indenter angle variations. The test is carried out by moving the indenter against the plate until the plate is damaged.FindingsThe results of this research show that the round indenter gave the best results in testing, while changes in speed below 1.5 m/s did not significantly affect the results. The contact angle of the indenter to the panel is directly proportional to the damage to the panel, and core X has the best results in the test.Originality/valueThis work presented several proposed eccentric sandwich panels to calculate their performance against impact loading. The detailed geometry for future reference is presented, while the indenter-panel interactions are validated based on experimental work.