bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Affects Postoperative Sinusitis and Implant Failure after Dental Implant: A Meta‐analysis
Authors: Kim Jong Seung , Choi Sang Moon , Yoon Ji Hyun , Lee Eun Jung , Yoon Jin , Kwon Sam Hyun , Yeo Cha Dong , Ryu Ji Seob , Lee Jong Hwan , You Yeon Seok , Kim Su Geun , Lee Min Hee , Han Baek Hwa 
Published: February 2019

ObjectiveThe dental implant is an innovative instrument that enables the edentulous patient to chew. Many factors have a bearing on the success of dental implantation. There are also many complications after dental implantation. In this meta‐analysis, we investigated which factors increase the risk of postoperative sinusitis and implant failure after dental implant for the first time.Data SourcesIncluded data were searched through the PubMed, EMBASE, and Cochrane library databases. We followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines, and 2 authors (J.S.K., S.H.K.) independently extracted data by multiple observers.Review MethodsWe used a random‐effects model considering the variation between and within the included studies.ResultsTwenty‐seven studies were included in our final meta‐analysis. The proportion of postoperative sinusitis, perforation of the sinus membrane, and implant failure was 0.05 (95% confidence interval [CI], 0.04‐0.07), 0.17 (95% CI, 0.13‐0.22), and 0.05 (95% CI, 0.04‐0.07), respectively, using the single proportion test. The only factors that affected postoperative sinusitis were preoperative sinusitis and intraoperative perforation of the Schneiderian membrane (P <. 01 and P <. 01, respectively). The only factors that affected dental implant failure were smoking and residual bone height of the maxilla (P <. 05 and P <. 01, respectively).ConclusionsTwo factors affect postoperative sinusitis after implant surgery: preoperative sinusitis and Schneiderian membrane rupture. It should also be noted that the factors affecting implant failure are residual bone height and smoking. These findings will have a significant impact on the counseling and treatment policy of patients who receive dental implants.
Recurrent Laryngeal Nerve Reinnervation in Rats Posttransection: Neurotrophic Factor Expression over Time
Authors: Montalbano Michael B. , Hernández‐Morato Ignacio , Tian Likun , Yu Victoria X. , Dodhia Sonam , Martinez Jose , Pitman Michael J. 
Published: February 2019

ObjectiveRecurrent laryngeal nerve (RLN) injury causes vocal fold paralysis from which functional recovery is typically absent due to nonselective reinnervation. This study investigates expression of axon guidance cues and their modulators relative to the chronology of reinnervation by examining the expression of glial‐derived neurotrophic factor (GDNF), netrin 1, and laminin 111 (LAMA1) in nonpooled laryngeal muscles. This study is the first to describe the post‐RLN injury expression pattern of LAMA1, a target of particular interest as it has been shown to switch netrin 1–mediated growth cone attraction to repulsion.Study DesignAnimal experiment (rat model).SettingBasic science laboratory.MethodsThe right RLNs of 64 female Sprague‐Dawley rats were transected, with sacrifice at 1, 3, 7, 21, 28, and 56 days postinjury (DPI). Single‐animal messenger RNA was isolated from the ipsilateral posterior cricoarytenoid (PCA), lateral thyroarytenoid (LTA), and medial thyroarytenoid (MTA) for quantitative reverse transcription polymerase chain reaction (qRT‐PCR) analysis. Immunostaining for LAMA1 expression was performed in the same muscles.ResultsLAMA1 was elevated in the PCA at 3 to 56 DPI, LTA at 7 DPI, and MTA at 14 and 28 DPI. This correlates with the chronology of laryngeal reinnervation. Using a new protocol, single‐animal muscle qRT‐PCR possible and expression results for GDNF and netrin 1 were similar to previous pooled investigations.ConclusionReliable qRT‐PCR is possible with single rat laryngeal muscles. The expression of netrin 1 and LAMA1 is chronologically coordinated with muscle innervation in the LTA and MTA. This suggests that LAMA1 may influence netrin 1 to repel axons and delay LTA and MTA reinnervation.
Value of diffusion-weighted imaging combined with conventional magnetic resonance imaging in the diagnosis of thecomas and their differential diagnosis with adult granulosa cell tumors
Authors: Fang Mengshi , Dong Jiangning , Zhong Qun , Fang Xin , Chen Yulan , Wang Chuanbin , Yan Hong 
Published: February 2019

Background Magnetic resonance imaging (MRI) is a significant method of identifying ovarian tumors, when combined with certain functional imaging techniques that have been considered to be more accurate. Purpose Our study aims to determine the value of diffusion-weighted imaging (DWI) combined with MRI in the diagnosis of thecomas and adult ovarian granulosa cell tumors (GCTs). Material and Methods In total, this study included 10 patients with thecomas and nine with adult GCTs. We analyzed the clinical characteristics, conventional MRI, and apparent diffusion coefficient (ADC) values of two groups. The methods of statistical analysis were univariate analysis and the receiver operating characteristic curve. Results According to T2-weighted imaging of the solid region of the mass, 80% (8/10) of thecomas showed slightly hypointense or mixed signals, but all adult GCTs showed slightly hyperintense signals. The two groups exhibited statistically significant differences ( P < 0.05) in morphology; presence of bleeding; the longest diameter of the cystic region; the ADC value; and the enhancement degrees of the venous and delayed periods. The mean ADC value for the thecoma group (1.30 ± 0.25 × 10−3mm2/s) was greater than that for adult GCT group (0.87 ± 0.28 × 10−3mm2/s) ( P < 0.05), and the cut-off value was 1.055 × 10−3mm2/s (AUC = 0.900, 95% CI = 0.675–0.989). Conclusion The combination of DWI and conventional MRI is of great value in the diagnosis of thecomas and their differential diagnosis with adult GCTs.
SMA-Coated Aluminum Structural Elements with Enhanced-Thermo-Mechanical Performance
Authors: Exarchos D.A. , Dalla P.T. , Tragazikis I.K. , Dassios K.G. , De Crescenzo C. , Karatza D. , Musmarra D. , Chianese S. , Matikas T.E. 
Published: February 2019

This work presents the development of novel multifunctional Shape Memory Alloy (SMA) coatings aiming to improve the mechanical behavior of structural components, as well as their corrosion resistance. The groundbreaking concept of the new coating material is described briefly as follows: Upon heating, the SMA coating tends to recover its experienced deformation and return to its original shape. At that point, shear forces developing at the interface between coating and structure are expected to mitigate the deformation of the structure and reduce its overall stress field level. The latter is a great benefit for regions where cracks exist, since the local reduction of the stress field will delay the crack propagation and hence the structural failure. Numerical analysis is performed to gain understanding of the expected thermomechanical response of the entire SMA-coated composite structure. The influence of the alloy composition and precipitates on the thermomechanical properties are also examined. The SMA coating is subjected to appropriate processing conditions and deposited on metallic substrates of proper geometry following a custom-designed two-phase process, which enables beneficial shape recovery enabling the efficient mitigation of the structure's deformation. Processing consists of aging heat treatments, which are of paramount importance for endowing the coating with the shape memory effect. The effect of heat treatment conditions on the thermo-mechanical fatigue response of the material was also characterized. The developed SMA coatings on aluminum structural elements can find significant application in aeronautical engineering, as for example in the aircraft wing box structure reinforcement and the fuselage structure to enhance their structural integrity.
Coenzyme Q10 supplementation reduces peripheral oxidative stress and inflammation in interferon-β1a-treated multiple sclerosis
Authors: Moccia Marcello , Capacchione Antonio , Lanzillo Roberta , Carbone Fortunata , Micillo Teresa , Perna Francesco , De Rosa Anna , Carotenuto Antonio , Albero Roberto , Matarese Giuseppe , Palladino Raffaele , Brescia Morra Vincenzo 
Published: February 2019

Background: Oxidative stress is a driver of multiple sclerosis (MS) pathology. We evaluated the effect of coenzyme Q10 (CoQ10) on laboratory markers of oxidative stress and inflammation, and on MS clinical severity. Methods: We included 60 relapsing–remitting patients with MS treated with interferon beta1a 44μg (IFN-β1a) with CoQ10 for 3 months, and with IFN-β1a 44μg alone for 3 more months (in an open-label crossover design). At baseline and at the 3 and 6-month visits, we measured markers of scavenging activity, oxidative damage and inflammation in the peripheral blood, and collected data on disease severity. Results: After 3 months, CoQ10 supplementation was associated with improved scavenging activity (as mediated by uric acid), reduced intracellular reactive oxygen species production, reduced oxidative DNA damage, and a shift towards a more anti-inflammatory milieu in the peripheral blood [with higher interleukin (IL)-4 and IL-13, and lower eotaxin, granulocyte-macrophage colony-stimulating factor (GM-CSF), hepatocyte growth factor (HGF), interferon (IFN)-γ, IL-1α, IL-2R, IL-9, IL-17F, macrophage inflammatory proteins (MIP)-1α, regulated on activation-normal T cell expressed and secreted (RANTES), tumor necrosis factor (TNF)-α, and vascular endothelial growth factor (VEGF). Also, CoQ10 supplementation was associated with lower Expanded Disability Status Scale, fatigue severity scale, Beck’s depression inventory, and the visual analogue scale for pain. Conclusions: CoQ10 supplementation improved scavenging activity, reduced oxidative damage, and induced a shift towards a more anti-inflammatory milieu, in the peripheral blood of relapsing–remitting MS patients treated with 44μg IFN-β1a 44μg. A possible clinical effect was noted but deserves to be confirmed over longer follow ups.
Clinical characteristics and prognosis in patients with chronic thromboembolic pulmonary hypertension and a concomitant psychiatric disorder
Authors: Tajima Hiroshi , Kasai Hajime , Tanabe Nobuhiro , Sugiura Toshihiko , Miwa Hideki , Naito Akira , Suda Rika , Nishimura Rintaro , Sanada Takayuki Jujo , Sakao Seiichiro , Tatsumi Koichiro 
Published: February 2019

Chronic thromboembolic pulmonary hypertension (CTEPH) can cause right heart failure. A concomitant psychiatric disorder (PD) is thought to increase the risk of acute pulmonary thromboembolism; however, whether PDs are associated with deterioration in CTEPH pathophysiology is unclear. In this study, we evaluated the clinical characteristics and prognoses in patients with CTEPH and a co‐existing PD. We retrospectively identified 229 consecutive patients (mean age = 58.7 ± 12.5 years; 160 women) with CTEPH and categorized them according to whether they had a PD (PD group; n = 22, 9.7%) or not (non‐PD group; n = 207, 90.3%). We compared the clinical characteristics, respiratory function, hemodynamics, and clinical courses in the two groups. Those in the PD group had significantly lower exercise tolerance compared to the non‐PD group (6‐min walk test, 309.5 ± 89.5 m vs. 369.4 ± 97.9 m, P = 0.008, percent vital capacity 85.5% ± 17.3% vs. 96.0% ± 15.5%, P = 0.003) and partial pressure of oxygen (PaO2) (54.4 ± 8.6 mmHg vs. 59.3 ± 10.7 mmHg, P = 0.039). Three‐year survival was significantly poorer in the PD group compared to the non‐PD group (66.1% vs 89.7%, P = 0.0026, log‐rank test), particularly in patients who underwent surgery (62.2% vs 89.5%, P < 0.001, log‐rank test). A concomitant PD was associated with low exercise tolerance and impaired respiratory function in patients with CTEPH and predicted poor survival, especially in those who underwent a pulmonary endarterectomy.
Targeting relatives: Impact of a cardiac rehabilitation programme including basic life support training on their skills and attitudes
Authors: González-Salvado Violeta , Abelairas-Gómez Cristian , Gude Francisco , Peña-Gil Carlos , Neiro-Rey Carmen , González-Juanatey José Ramón , Rodríguez-Núñez Antonio 
Published: February 2019

Background Training families of patients at risk for sudden cardiac death in basic life support (BLS) has been recommended, but remains challenging. This research aimed to determine the impact of embedding resuscitation training for patients in a cardiac rehabilitation programme on relatives' BLS skill retention at six months. Design Intervention community study. Methods Relatives of patients suffering acute coronary syndrome or revascularization enrolled on an exercise-based cardiac rehabilitation programme were included. BLS skills of relatives linked to patients in a resuscitation-retraining programme (G-CPR) were compared with those of relatives of patients in a standard programme (G-Stan) at baseline, following brief instruction and six months after. Differences in skill performance and deterioration and self-perceived preparation between groups over time were assessed. Results Seventy-nine relatives were included and complete data from 66 (G-Stan=33, G-CPR=33) was analysed. Baseline BLS skills were equally poor, improved irregularly following brief instruction and decayed afterwards. G-CPR displayed six-month better performance and lessened skill deterioration over time compared with G-Stan, including enhanced compliance with the BLS sequence ( p = 0.006 for group*time interaction) and global resuscitation quality ( p = 0.007 for group*time interaction). Self-perceived preparation was higher in G-CPR ( p = 0.002). Conclusions Relatives of patients suffering acute coronary syndrome or revascularization enrolled on a cardiac rehabilitation programme showed poor BLS skills. A resuscitation-retraining cardiac rehabilitation programme resulted in relatives' higher BLS awareness, skill retention and confidence at six months compared with the standard programme. This may suggest a significant impact of this formula on the family setting and support the active role of patients to enhance health education in their environment.
Cardiovascular effects of space radiation: implications for future human deep space exploration
Authors: Mitchell Adam , Pimenta Dominic , Gill Jaspal , Ahmad Haris , Bogle Richard 
Published: February 2019

Background A manned mission to Mars has been contemplated by the world's largest space agencies for a number of years. The duration of the trip would necessitate a much longer exposure to deep space radiation than any human has ever been exposed to in the past. Concern regarding cancer risk has thus far stalled the progress of deep space exploration; however, the effect of space radiation on the cardiovascular system is significantly less well understood. Discussion Damage by radiation in space is mediated by a number of sources, including X-rays, protons and heavier charged atomic nuclei (HZE ions, the high-energy component of galactic cosmic rays). Previously, only lunar mission astronauts have been exposed to significant deep space radiation, with all other missions being low earth orbits only. The effect of this radiation on the human body has been inconclusively studied, and the long-term damage caused to the vascular endothelium by this radiation due to the effect of high-energy particles is not well known. Conclusion Current radiation shielding technology, which would be viable for use in spacecraft, would not eliminate radiation risk. Similar to how a variety of shielding techniques are used every day by radiographers, again without full risk elimination, we need to explore and better understand the effect of deep space radiation in order to ensure the safety of those on future space missions.
Physical Function and Quality of Life After Resection of Mobile Spine Chondrosarcoma
Authors: Paulino Pereira Nuno Rui , Janssen Stein J. , Stoop Nicky , Hartveldt Stefan , Chen Yen-Lin E. , DeLaney Thomas F. , Hornicek Francis J. , Schwab Joseph H. 
Published: February 2019

Study Design: Retrospective cohort study. Objectives: (1) To assess patient-reported outcomes—physical function, pain, and quality of life—in patients who underwent resection of a mobile spine chondrosarcoma. (2) To assess complications (90 days), readmissions, reoperations, oncological outcomes, and neurologic status. Methods: Thirty-three patients with spinal conventional chondrosarcoma resection between 1984 and 2014 at one hospital were included. The primary outcome measures were—minimally 6 months after surgery—the EuroQol 5 Dimensions (EQ5D), PROMIS–Physical Function, PROMIS–Pain Intensity, and Oswestry (ODI) Disability Index, or Neck (NDI) Disability established in 14 out of 20 alive (70.0%) patients. Complications, readmission, reoperations, oncological outcomes, and neurological status were reported for the complete cohort of 33 patients. Results: After spine chondrosarcoma resection, patients (n = 14) reported worse physical function (median 43, range 22-61, P = .026), worse quality of life (median EQ5D 0.70, range 0.04-1, P = .022), and comparable pain intensity (median 47, range 31-56, P = .362) when compared with US general population values. The median NDI/ODI was 25 (range 0-72) indicating mild to moderate disability. Patients undergoing reoperation had worse patient-reported outcomes than those who did not. Eighteen (55.5%) out of 33 patients suffered complications (90 days), 14 (42.4%) had unplanned readmission, and 13 (39.4%) underwent reoperation. Intralesional resection was associated with increased readmission, reoperation, and recurrence rate. Conclusions: Chondrosarcoma affects quality of life and physical function and its treatment frequently results in complications and reoperations. Our findings can be used to inform future patients about expected outcomes.
A previously unreported type of extra-articular triplane fracture: A revised classification system
Authors: Yung Colin S , Kuong Evelyn E , Chow Wang 
Published: February 2019

Background: Atypical triplane fractures are defined as triplane fractures that are intra-articular but affect the non-weight-bearing area of the tibia plafond or extra-articular triplane fractures where the epiphyseal fracture line exits outside the articulating cortex of the medial malleolus. These fractures are scarcely reported in the literature. Here, we study the fracture pattern, mechanisms, and recommendations for management. Methods: This is a retrospective study of all triplane fractures identified from 2012 to 2016 in a tertiary referral center. There were 10 atypical triplane fracture patterns identified in this cohort. All patients were followed up with an average of 19 months. A modified atypical triplane fracture classification was devised and compared with previously reported classification systems. Clinical outcomes measured included treatment complications, ankle range of motion, and time needed to return to sports. Results: We identified a new extra-articular triplane fracture variant with an anteromedial epiphyseal sleeve fragment (fracture variant). There were no long-term complications from operative closed reduction and percutaneous screw fixation. Operative cases had earlier ankle mobilization and regained full range of motion (12.8 weeks vs 13.3 weeks) earlier. The average time to return to sports was 5.2 months. Conclusions: We propose a modified classification for atypical triplane fractures and recommend closed reduction and percutaneous screw fixation for displaced atypical triplane fractures. Level of Evidence: IV (Case Series).
A role for IL-34 in osteolytic disease of multiple myeloma
Authors: Baghdadi Muhammad , Ishikawa Kozo , Nakanishi Sayaka , Murata Tomoki , Umeyama Yui , Kobayashi Takuto , Kameda Yosuke , Endo Hiraku , Wada Haruka , Bogen Bjarne , Yamamoto Satoshi , Yamaguchi Keisuke , Kasahara Ikumi , Iwasaki Hiroshi , Takahata Mutsumi , Ibata Makoto , Takahashi Shuichiro , Goto Hideki , Teshima Takanori , Seino Ken-ichiro 
Published: February 2019

AbstractMultiple myeloma (MM) is a hematological malignancy that grows in multiple sites of the axial skeleton and causes debilitating osteolytic disease. Interleukin-34 (IL-34) is a newly discovered cytokine that acts as a ligand of colony-stimulating factor-1 (CSF-1) receptor and can replace CSF-1 for osteoclast differentiation. In this study, we identify IL-34 as an osteoclastogenic cytokine that accelerates osteolytic disease in MM. IL-34 was found to be expressed in the murine MM cell line MOPC315.BM, and the expression of IL-34 was enhanced by stimulation with proinflammatory cytokines or by bone marrow (BM) stromal cells. MM-cell–derived IL-34 promoted osteoclast formation from mouse BM cells in vitro. Targeting Il34 by specific small interfering RNA impaired osteoclast formation in vitro and attenuated osteolytic disease in vivo. In BM aspirates from MM patients, the expression levels of IL-34 in CD138+ populations vary among patients from high to weak to absent. MM cell–derived IL-34 promoted osteoclast formation from human CD14+ monocytes, which was reduced by a neutralizing antibody against IL-34. Taken together, this study describes for the first time the expression of IL-34 in MM cells, indicating that it may enhance osteolysis and suggesting IL-34 as a potential therapeutic target to control pathological osteoclastogenesis in MM patients.
Managing the airway catastrophe: Longitudinal simulation-based curriculum to teach airway management
Authors: Nguyen Lily H. P. , Bank Ilana , Fisher Rachel , Mascarella Marco , Young Meredith 
Published: February 2019

Background A longitudinal curriculum was developed in conjunction with anesthesiologists, otolaryngologists, emergency physicians and experts in medical simulation and education. Methods Residents participated in four different simulation-based training modules using animal models, cadavers, task trainers, and crisis scenarios using high fidelity manikins. Scenarios were based on various clinical settings (i.e. emergency room, operating room) and were followed by video-assisted structured debriefings. Participants completed both a self-assessment questionnaire and an exit survey using five-point Likert scales. Results 31 otolaryngology residents participated in the curriculum. Residents reported simulation training significantly improved technical skills such as tracheostomy, cricothyroidotomy and pediatric intubation ( p < 0.05 for all). Non-technical skills, including communication, delegation and management were significantly improved on post-test surveys in simulated crisis scenarios ( p < 0.05 for all). 90 (28/31) of participants found simulations to be very realistic. Junior residents placed increased value on didactic teaching and procedural skills, while senior residents on crisis scenarios. Survey results indicated that > 90% (28/31) of participants found the modules of the curriculum to be useful and would recommend them to others. Conclusion A longitudinal simulation-based medical curriculum can be an effective method to teach airway management and teamwork skills to otolaryngology residents.