bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of intestinal parasitic infection and associated factors among pregnant women attending antenatal care at public health facilities in Lalo Kile district, Oromia, Western Ethiopia
Authors: Yesuf Dejene Abraham , Abdissa Lensa Tesfaye , Gerbi Emiru Adeba , Tola Edosa Kifle 
Published: October 2019

Abstract
Objective : This study aimed to assess the prevalence of intestinal parasitic infection and associated factors among pregnant women attending antenatal care at public health facilities in Lalo Kile district, Oromia, Western Ethiopia. Results : Out of the 315 respondents, the mean age was 24.7 ± 2.54 year ranging between 15-44 years. Majority of the respondents were Oromo in ethnicity (90.2%) and protestant in religion (83.2%) and almost all (99%) of the study participants were married. Regarding educational level, two hundred twenty-six (72%) of pregnant women were attended at least primary school and two hundred forty-six (78.1%) of the respondents were from farmer households. About half of the households (51.7%) had a monthly income of greater than 1000 ETB. The overall prevalence of intestinal parasitic infection was 43.8 %( 138/315) with the predominance of hookworm (33.7%) followed by Ascaris lumbricoides (7.3%). Being a farmer (AOR, 7.3; 95% CI: 1.46, 37.00), walking barefooted (AOR, 6.13; 95% CI: 1.98, 19.00) and absence of handwashing with soap and water after latrine (AOR, 5.36; 95% CI: 1.78, 16.00) were significantly associated with occurrence of the intestinal parasitic infection with p-value < 0.05. Keywords : Prevalence, Intestinal parasitic infection, pregnant women, Lalo Kile district
Efficient development of practically usable thermo-photo sensitive genic male sterile lines in wheat through doubled haploid breeding
Authors: Li Hongsheng , Li Shaoxiang , Abdelkhalik Sedhom , Shahzad Armaghan , Gu Jian , Yang Zhonghui , Ding Mingliang , Liu Kun , Zhao Hong , Yang Mujun 
Published: October 2019

Abstract
Two-line hybrid wheat system using thermo-photo sensitive genic male sterility (TPSGMS) is now a dominant and promising approach of wheat heterosis utilization in China. However, few TPSGMS lines available for practical application have always been a bottleneck affecting the efficiency of creating hybrids with strong heterosis since its establishment in 1992. This study aimed to improve the efficiency of developing TPSGMS lines by doubled haploid (DH) breeding. F 1 s and selected F 2 and F 3 sterile plants from 8 crosses made with 2 commercial TPSGMS lines K78S and K456S were used to produce DH lines by wheat × maize system. 24 elite sterile lines possessing stable sterility, good outcrossing and yield potentials, resistance to yellow rust and powdery mildew, and desirable plant height (50-60 cm) were obtained within 4 years. 20 out of 24 elite lines that performed stable sterility in tests of two or three years and high outcrossing rate (>70%) under open pollination, will be used for hybrid breeding later. The percentage of selected sterile lines in total tested DH lines produced from filial generations was in the order of F 3 > F 2 > F 1 for sterility, and F 2 > F 3 > F 1 for elite lines in this study, thus producing DHs from F 2 generation appeared to be the better choice considering the balance of overall breeding efficiency and time saving. This study verified that combining DH techniques with conventional breeding would be an efficient strategy for developing practically usable wheat TPSGMS lines, both in number and time saving.
Acceptability and practicability of self-management for patients with Parkinson's disease based on smartphone applications in China
Authors: Hu Jie , Yuan Dezhi , Zhao Qiuye , Wang Xuefei , Zhang Xiaotian , Jiang Qihui , Luo Huirong , Li Jing , Ran Jianhua , Li Jinfang 
Published: October 2019

Abstract
Background China has had about 1.2 billion mobile-phone users and the usage has been still growing, however, mobile-health(m-Health) services are currently in the initial stage and have not yet prevailed. Additionally, the prevalence of Parkinson's disease (PD) is 190/100,000 in China, and patients need m-Health to manage their PD. Therefore, this study was designed to determine the attitudes and practicability towards about smartphone applications (APPs) of self-management of chronic condition among the elderly with PD in China.Methods Total 204 participants with PD were selected, from 52 to 87 years, and conducted by attitude surveys concerning using APPs for managing chronic condition via questionnaires.Results Among the total participants, 65.19% subjects had smartphones, and 82.84% ones preferred to use APPs for PD management, who were younger and more frequent web users with higher education standards and better medication compliance as well as longer PD courses and worse conditions of PD, compared with the rest of subjects( P < 0.001, P = 0.001, P < 0.001, P = 0.041, P < 0.001, P = 0.013. Additionally, the preference of patients for the use of the APPs is positively related to education standards( P < 0.001), while negatively related to age and PD course ( P = 0.017, P < 0.001).Conclusion Patients with PD are positive about self-management of smartphone APPs in China. Consequently, improving the coverage of smartphones developing practical and handy APPs would become a novel and promising strategy for PD self-management.
Prognostic factor for the response to intravitreal bevacizumab treatment in central serous chorioretinopathy patients.
Authors: Lee Chunghyun , Kim Yu Jeong , Joe Soo Geun , Yang Sungjae 
Published: October 2019

Abstract
Objective To evaluate prognostic factors associated with good response to intravitreal bevacizumab (IVB) treatment in central serous chorioretinopathy (CSC) patients. Methods We retrospectively reviewed ninety-four eyes of 94 CSC patients who received intravitreal bevacizumab injection(IVB) (0.05 ml, 1.25 mg) as a first line treatment. Patients were divided into two groups as good responders and poor responders based on optical coherence tomography (OCT) findings 1 month after the first injection of intravitreal bevacizumab. Good responders were defined as complete resolution of subretinal fluid (SRF) on OCT 1 month after IVB. We compared baseline visual acuity, duration of symptoms, angiographic findings on fluorescein angiography, central retinal thickness (CRT), macular volume (MV),subfoveal choroidal thickness (SFCT) between two groups. Results 42 eyes were included as good responder and 52 eyes as poor responders. Mean age was 47.8±7.4 year old ingood responders and 50.6±7.8 year old in poor responders. Baseline visual acuity (logMAR) was better in good responders than poor responders, 0.19±0.19 and 0.29±0.19 respectively (p=0.015). SFCT was significantly thicker in good responders than poor responders 419.7±103.2㎛ and 376.0±99.0㎛ respectively (p=0.040). Prevalence of chronic cases was higher in poor responders (33/52) than good responders (15/42), (p=0.012). There was no statistical significance in age, sex, CRT, MVbetween two groups. Conclusion Intravitreal injection of bevacizumab can be potential option for the treatment of CSC patients, especially in case of recent onset, better baseline visual acuity with thicker choroid on OCT.
Association between susceptibility of diabetic nephropathy and gene polymorphisms in ELMO1 and IL-8: a systemic review and meta-analysis
Authors: Zhu Yanting , Wang Xiaoming , Sun Yan , Wang Qiong , Wu Bing , Zhou Penghua , Li Zhenjiang 
Published: October 2019

Abstract
Background: The engulfment and cell motility 1 (ELMO1) and interleukin-8 (IL8) gene polymorphisms have been previously implicated in diabetic nephropathy (DN) susceptibility. However, the results are inconsistent. We aimed to examine this issue by systematic meta-analysis. Methods: An electronic search was conducted in PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure and Wanfang Database to identify all the eligible studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to investigate the associations. All statistical analyses were performed by STATA 12.0. Results: Of the 11 studies included, 9 studies were performed to detect EMLO1 rs741301 polymorphism; 5 studies were used to examine IL-8 rs4073 polymorphism. The results revealed no significant association between EMLO1 rs741301 polymorphism and DN risk. While, stratified analysis by ethnicity indicated that EMLO1 rs741301 polymorphism was associated with an increased risk of DN risk among Asians (GG vs. GA +AA: OR= 1.840, 95% CI= 1.338-2.529, P= 0.000; GG vs. AA: OR= 1.834, 95% CI= 1.309-2.569, P= 0.000; G vs. A: OR= 1.222, 95% CI= 1.053-1.417, P= 0.008). As for IL-8 rs4073 polymorphism, a positive correlation between this gene polymorphism and DN risk was found (AA+AT vs. TT: OR= 1.450, 95% CI= 1.166-1.802, P= 0.001; AT vs. TT: OR= 1.420, 95% CI= 1.129-1.786, P= 0.003; AA vs. TT: OR= 1.553, 95% CI= 1.094-2.203, P= 0.014; A vs. T: OR= 1.291, 95% CI= 1.102-1.512, P= 0.002). After stratified population by ethnicity, the results in Caucasians remained significant (AA+AT vs. TT: OR= 1.770, 95% CI= 1.354-2.315, P= 0.000; AT vs. TT: OR= 1.733, 95% CI= 1.304-2.302, P= 0.000; AA vs. TT: OR= 1.939, 95% CI= 1.263-2.976, P= 0.002; A vs. T: OR= 1.494, 95% CI= 1.227-1.820, P= 0.000). Conclusions: This meta-analysis indicates that the GG genotype of EMLO1 rs741301 polymorphism and the A allele of IL-8 rs4073 polymorphism might be risk factors for the development of DN.
Research on the health of and interventions for family caregivers of people with dementia: a bibliometric analysis of research output during 1988–2018
Authors: Shi Hui , Mao Chen , Tang Jinling , Liang Huiying 
Published: October 2019

Abstract
Background: Dementia is a large and growing health problem, and since the majority of dementia patients live at home, caring responsibilities generally fall to family members. Caregivers are often inadequately supported by formal health services and have poorer psychological and physical health. Our study aimed to compare the contributions of publications from different countries, institutions and authors and present a bibliometric analysis to determine the future hotspots and trends in research on the health of and interventions for family dementia caregivers. Methods: Studies published during 1988-2018 were extracted from the Science Citation Index Expanded of the Web of Science. Each publication was evaluated to obtain the basic information. Bibliometric analysis was used to evaluate the number or cooperation networks of publications, countries, institutions, journals, citations, authors, references, and keywords. The resulting articles were analyzed descriptively, and data were produced for VOSviewer. Results: Five hundred forty-two articles were identified.The annual number of relevant publications has increased steadily since approximately 2006. The USA has the highest number of publications (36.2%), followed by the UK (12.9%). China entered late, but research there has developed rapidly. The most productive institution, journal, and author in this field are University College London, the Journal of the American Geriatrics Society, and Orrell M from the UK, respectively. A co-occurrence analysis of keywords reveals a mainstream research focus on burden, depression, quality of life, and corresponding interventions for dementia patient caregivers. The keywords “psychosocial intervention”, “long-term”, “e-learning/online”, “communication”, and “qualitative research” reflect the latest hotspots, appearing in approximately 2017-2018. Conclusion: Our study details the performance statistics of and the main topics and trends in the research on the health of and interventions for dementia caregivers from 1988 to 2018 and provides a comprehensive analysis.
Creating Successful Elder-Friendly Spaces: A Conceptual Framework for Urban Public Spaces
Authors: Lak Azadeh , Aghamolaei Reihaneh , Baradaran Hamid R , Myint Phyo K 
Published: October 2019

Abstract
Background: Although issues of elderly people’s active life in public spaces are increasingly being reevaluated, the amount of research dedicated to enhancing urban public space qualities based on the concept of elders’ preferences is still limited. Methods: This study aims to identify the elders’ preferences specially their use of public open spaces in residential neighborhoods. The research applied in two steps; first, Grounded Theory (GT) is conducted through semi-structured interviews. 52 in-depth interviews are conducted with the elderly. Results: The analyzed data will then be examined to extract the main categories. Second, the survey is conducted through a questionnaire developed by authors, inquiring 350 elder people and analyzed by SmartPLS technique to validate the results of the developed model Conclusion: The model of the elders’ preferences consists of Places Functional (PF), Places Preferences (PP), and Process in Environments (PE). The findings will highlight both their theoretical and practical implications for urban planners and designers.
Factors influencing postoperative LOS after fragility hip fracture surgery: public perceptions – a mixed methods study
Authors: Marufu Takawira , Almghairbi Dalal , Elphick Heather , Ahmed Farah B , Moppett Iain K 
Published: October 2019

Abstract
Background Postoperative patient outcomes after hip fracture are significant to patients and their relatives, clinicians and policy makers. However, little is known about the collective views of these stakeholders on postoperative factors perceived to cause prolonged hospitalisation in this patient population. We aimed to explore individual stakeholders’ opinions on factors influencing timing of discharge.Methods Using a mixed methods approach, healthcare professionals, patients and relatives completed a questionnaire and interviews. The questionnaire consisted of 13 morbidity and non-medical domains on a five-point Likert scale. Participants were asked to rank each item identifying its importance in influencing length of hospital stay; 1 = strongly disagree, 2 = disagree, 3 = neither disagree nor agree, 4 = agree, 5 = strongly agree. Interviews were semi-structured exploring participant perceptions.Findings Twenty-six participants completed both interviews and questionnaires; three completed questionnaires only. Five themes affecting LOS emerged from interview data analysis; medical conditions, age and frailty, psychological aspects, the recovery process and social issues. There were some differences between the importance attributed by the semi-quantitative rating scales and the qualitative themes generated. Quantitative data suggested medical factors (pulmonary, infectious, gastrointestinal, cardiovascular, neurological, haematological, wound and pain). The interviews however highlighted functional and social aspects of recovery as key for patients and relative participants.Conclusion Recovery and discharge from hospital following hip fracture is understood by patients, carers or staff to be a complex interplay between medical conditions, psychosocial factors and the practicalities of living with increased dependency. Approaches to improving outcome will need to address each of these domains if they are to be effective.
Marital Status, An Independent Predictor for Survival of Gastric Neuroendocrine Neoplasm Patients: A Population-based, Propensity Score-matched Study
Authors: Zhou Yu-Jie , Lu Xiao-Fan , Zheng Kenneth I. , Wang Qi-Wen , Chen Jin-Nan , Zhang Qing-Wei , Yan Fang-Rong , Li Xiaobo 
Published: October 2019

Abstract
Background Marital status proves to be an independent prognostic factor in a variety of cancers. However, its prognostic impact on gastric neuroendocrine neoplasms (G-NEN) has not been investigated.Material and Methods We identified 3947 G-NEN patients from the Surveillance, Epidemiology, and End Results (SEER) database. Meanwhile, propensity scores for marital status were used to match 506 unmarried patients with 506 married patients. We used Kaplan–Meier method and multivariate Cox regression to analyse the association between marital status and the overall survival (OS) and G-NEN cause-specific survival (CSS) before matching and after matching.Results Married patients enjoyed better OS and CSS, compared with divorced/separated, single, and widowed patients. Multivariate Cox regression analysis indicated that unmarried status was associated with higher mortality hazards for both OS and CSS among G-NEN patients. Additionally, widowed individuals had the highest risks of overall and cancer-specific mortality compared to other unmarried groups in both males and females. Furthermore, marital status remained an independent prognostic and protective factor for both OS and CSS in 1:1 propensity score-matched analysis.Conclusion Marital status was an independent prognostic factor for G-NEN. Meanwhile, widowed patients with G-NEN had the highest risk of death compared with single, married, and divorced/separated patients.
The body weight-walking distance product as a superior parameter in determining the VO2 on-kinetics in coronary artery disease
Authors: Rocco Isadora S. , Gomes Walter J. , Pauletti Hayanne O. , Viceconte Marcela , Matos-Garcia Bruna C. , Moreira Rita Simone L. , Arena Ross , Guizilini Solange 
Published: October 2019

Abstract
Background The 6-minute walk test distance is frequently used to assess functional capacity of cardiac disease population. Nevertheless, anthropometric differences can confound or misestimate performance, which highlights the need for new parameters. This study aims to investigate the potential of the body weight-walking distance product (D.W), compared to 6-minute walk test distance, to predict exercise capacity measured by VO 2 on-kinetics in coronary artery disease (CAD) patients.Methods Cross-section study in a tertiary-care reference institution. Forty-six participants with multiarterial CAD with and without left ventricular dysfunction underwent a 6-minute walk test with simultaneous use of mobile telemetric cardiopulmonary monitoring to evaluate oxygen uptake (VO 2 ) on-kinetics and other cardiorespiratory responses.Results Perceived effort Borg for lower limb fatigue was only correlated with the D.W (p=0.007). The percent-predicted and actual distance were only modestly to moderately correlated with VO 2 on-kinetics (p<0.05). All the associations of VO 2 on-kinetics parameters were improved by showing a stronger correlation to the D.W (p<0.0001), which also had a larger effect size to identify differences between coronary disease patients compared to distance ( d =1.32 vs d =0.84).Conclusion The D.W demonstrates potential as a measure superior to the distance in determining VO 2 on-kinetics in participants with CAD with and without left ventricular dysfunction.
microRNA-30c promotes myocardial ischemia reperfusion injury by activating SIRT1 mediating NF-κB pathway
Authors: Chen Jianfeng , Xue Shufeng , Zhang Mingming , Wu Junlong , Zhang Shouyan 
Published: October 2019

Abstract
Background This study aimed to investigate the effect of miR-30c on myocardial ischemia reperfusion (IR) injury and its underlying molecular mechanisms.Methods In our study, rat myocardial IR injury model was established and hemodynamic examination was performed. Moreover, the myocardial infarct size was detected by TTC staining. The pathologic change of myocardial tissues was measured by HE staining. The myocardial cell apoptosis was measured by TUNEL staining and flow cytometry. The expression of miR-30c and Sirtuin 1 (SIRT1) was detected by qRT-PCR. The levels of IL-1β, IL-6 and TNF-α were detected by ELISA. The expressions of Bax, Bcl-2, caspase-3, p-IκBα, IκBα, p-NF-κB p65, NF-κB p65 and SIRT1 were detected by western blot. The luciferase activity was measured by dual luciferase reporter gene assay. Interaction between miR-30c and SIRT1 were analyzed by RNA immunoprecipitation assay.Results Our results showed that rat myocardial IR injury model was successfully established and IR injury induced myocardial injury in rats. miR-30c increased the levels of IL-1β, IL-6 and TNF-α and myocardial cell apoptosis by activating NF-κB pathway. In addition, we also confirmed that SIRT1 was the target gene of miR-30c. SIRT1 could reverse the effect of miR-30c on the process of inflammation and apoptosis, as well as the activation of NF-κB pathway in myocardial cells.Conclusions Our study demonstrated that miR-30c could promote myocardial ischemia reperfusion injury through activating SIRT1 mediating NF-κB pathway.
Hole edge morphology by intraoperative OCT predicts restoration of the retina microstructure in macular hole surgery
Authors: Tao Jiwei , Chen Huan , Zhu Lin , Pan Deming , Fang Jia , Chen Yiqi , Mao Jianbo , Shen Lijun 
Published: October 2019

Abstract
Objectives: To investigate the association between iOCT feature inmacular hole surgery and the restoration of the retina microstructure and visualoutcomes. M ethods: Fifty-three eyes of 53 patients with macular hole were recruited in this retrospective study. All eyes were assessed with intraoperative OCT after internal limiting membrane peeling. We divided the patients in to three groups:fovel flap group, hole-door group, and negative group，according to morphological changes on the edge of hole using iOCT after ILM peeling. We compared the anatomical and functional surgical outcomes between these groups. ResultsThe negative group had significantly poorer BCVA and restoration of the ELM than other two groups(P=0.002,0.012) at 6 months postoperatively. In the hole size ≤400um group，There were no statistical difference of ELM restoration and BCVA postoperatively between the groups. While in hole size > 400um group, The hole-door group and fovea flap group had significantly better final visual acuity and restoration of ELM than the negative group(P=0.013,P=0.005) Conclusion: This study describes a novel intraoperative sign using iOCT. This sign is a useful predictor of postoperative in restoration of the retina microstructure and visual outcomes of the macular hole，especially in large macular hole.
Correlation between macular edema recurrence and macular capillary network destruction in branch retinal vein occlusion
Authors: Jang Ji Hye , Kim Yu Cheol , Shin Jae Pil 
Published: October 2019

Abstract
Purpose: To evaluate the correlation between changes of the macular capillary network and macular edema (ME) recurrence in branch retinal vein occlusion (BRVO) using swept-source optical coherence tomography (SS-OCT) angiography. Methods: We reviewed the data of 43 patients with treatment-näive ME associated with BRVO. Patients who received intravitreal bevacuzumab injection were divided into two groups based on ME recurrence after 6 months after edema resolution. The perifoveal capillary morphology and the macular capillary vessel density (VD) were retrospectively analyzed with en face SS-OCT angiography image after ME resolution. Results: In the ME recurrence group (n=22), a broken the perifoveal capillary ring in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) was more common than the no ME recurrence group (p = 0.047 and p = 0.002). The destruction of the perifoveal capillary ring of the DCP (30.0° vs 87.3°, p = 0.001) was more severe than that of the SCP (17.3° vs 69.5°, p = 0.006) in the ME recurrence group compared with the no ME recurrence group. The hemi-VD disparity between the affected areas and the unaffected areas in the SCP and DCP showed significant differences (p = 0.031 and p = 0.017), while macular VD showed no differences between the groups. Conclusions: The destroyed perifoveal capillary ring and the hemi-VD disparity were related to the recurrence of ME in BRVO. Therefore, these factors can be helpful in predicting ME recurrence.