bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Outcomes of Minimally Invasive Endoscopic Versus Sternotomy Surgical Resection of Primary Cardiac Tumors
Authors: Aboelnazar Nader S. , Loshusan Brandon R. , Chu Michael W. A. 
Published: October 2024

Objective: Primary cardiac tumors are uncommon, often benign, but can be potentially life threatening. Minimally invasive endoscopic (ENDO) techniques have been shown to be a feasible alternative for tumor resection compared with conventional sternotomy (CS). This study compared the clinical and surgical outcomes of a small series of patients undergoing cardiac tumor resection operations. Methods: Between November 2009 and December 2022, 34 consecutive patients underwent cardiac tumor resection using either ENDO ( n = 21) or CS ( n = 13) techniques. We compared early perioperative outcomes, echocardiographic outcomes, and long-term clinical and tumor recurrence outcomes. Results: Baseline characteristics were similar between groups; however, the ENDO group included younger patients (56 ± 16 vs 62 ± 17 years) and more female patients (83% vs 53%). The tumor was located in the left atrium ( n = 19, 56%), right atrium ( n = 5, 15%), or either ventricle ( n = 4, 12%). In-hospital mortality and stroke frequency were similar for both groups ( n = 0). There was no significant difference in cardiopulmonary bypass or cross-clamp times, respiratory or renal failure, or intensive care unit or hospital lengths of stay. At follow-up (ENDO, 42 [2 to 131] months vs CS, 54 [1 to 156] months), there were no deaths in the ENDO group and 2 patients died in the CS group ( P = 0.21). No patients in either group experienced tumor recurrence. Conclusions: In selected patients, both ENDO and CS approaches to primary cardiac tumor resection were safe, effective, durable, and associated with similarly good early and late results.
A Risk Prediction Model for Prolonged Length of Stay After Minimally Invasive Valve Surgery
Authors: Bruno Vito D. , Celmeta Bleri , Viva Tommaso , Bisogno Arturo , Miceli Antonio , Glauber Mattia 
Published: October 2024

Objective: Minimally invasive surgery determines shorter postoperative hospital length of stay (LOS) even in cardiac surgery. Potential preoperative factors affecting LOS are still not known in minimally invasive heart valve surgery (MIVS). We aimed to identify preoperative variables influencing prolonged LOS in MIVS. Methods: We reviewed 189 patients who underwent MIVS via minithoracotomy at our institution. Prolonged LOS was defined as more than 7 postoperative days. Poisson and logistic regression were used to screen the predictors. Results: The mean postoperative LOS was 9.13 days, and 64 patients (33.9%) experienced a prolonged LOS. These patients were older, more frequently in New York Heart Association (NYHA) class III or IV, showed worse left ventricular ejection function (LVEF), and had a higher incidence of reoperation and chronic kidney disease (CKD). At univariate analysis, the most significant preoperative factors affecting prolonged LOS were age (odds ratio [OR] = 1.04), NYHA class III or IV (OR = 3.03), reduced LVEF (OR = 3.22), CKD (OR = 2.7), and redo surgery (OR = 3.6). After adjustment, the most significant preoperative factors predicting prolonged LOS were age (OR = 1.03, 95% CI: 1.01 to 1.06, P = 0.02) and redo surgery (OR = 3.33, 95% CI: 1.29 to 8.9, P = 0.01). Conclusions: The most important factors affecting prolonged LOS after MIVS were represented by age and redo surgery, although other preoperative characteristics such as reduced LVEF, NYHA class III or IV, and CKD play a significant role in delaying recovery after MIVS. Further larger studies are needed to better identify potential preoperative predictors of prolonged LOS after MIVS.
“Chopperlysis”: The effect of helicopter transport on reperfusion and outcomes in large vessel occlusion strokes
Authors: Koneru Manisha , Thon Jesse M , Dubinski Michael J , Fornari Caprara Ana Leticia , Brown Danielle C , Yi Zixin , Elgendy Omnea , Ackerman Jiyoun , Penckofer Mary , Shi Rosa , Fang Misa , Garfinkel Lucas , Thomas Tarun , Patel Karan , Frost Emma , Kalladanthyil Abyson , Sprankle Kenyon , Oliveira Renato , Santucci Joshua , Ballout Ahmad A , Siegler James E , Schumacher Hermann C , Hanafy Khalid A , Khalife Jane , Patel Pratit D , Tonetti Daniel A , Thomas Ajith J , Jovin Tudor G , Shaikh Hamza A 
Published: October 2024

Background In large vessel occlusion (LVO) stroke patients transferred to a comprehensive stroke center for thrombectomy, spontaneous reperfusion may occur during transport, and anecdotally more frequently in patients transferred via helicopter than by ground. This pattern has been more often observed in conjunction with tenecteplase (TNK) treatment prior to helicopter transport. We aim to explore the “chopperlysis” effect—how helicopter transport, particularly with thrombolytics, may affect reperfusion and clinical outcomes. Methods A single thrombectomy capable center (TCC) registry of stroke patients was retrospectively reviewed. Included LVO patients were those who had been transferred to the TCC and received a digital subtraction angiography (DSA) upon arrival. The outcomes were rates of spontaneous reperfusion, distal clot migration, and 90-day good functional outcome. Data were summarized, and endpoints were compared between patients stratified by transport method and/or TNK treatment. Results Of 270 patients included, helicopter transport was associated with a higher rate of spontaneous reperfusion, particularly among patients not treated with TNK ( p < 0.001). There was no significant difference in prevalence of distal clot migration between any subgroups ( p > 0.37). Overall, TNK-treated patients had better functional outcomes, and this difference persisted exclusively in the helicopter-transported patients ( p = 0.02). Conclusion Helicopter transport was associated with a higher rate of spontaneous reperfusion. There is a potentially synergistic effect between TNK administration and helicopter transport, augmenting thrombolysis and improving long-term outcomes. Further analyses in larger cohorts may expand our understanding of this “chopperlysis” effect.
Redeployment experiences of healthcare workers in the UK during COVID-19: a cross-sectional analysis from the nationwide UK-REACH study
Authors: Zuzer Lal Zainab , Martin Christopher A. , Gogoi Mayuri , Qureshi Irtiza , Bryant Luke , Papineni Padmasayee , Lagrata Susie , Nellums Laura B , Al-Oraibi Amani , Chaloner Jonathon , Woolf Katherine , Pareek Manish 
Published: October 2024

Objectives To assess how ethnicity, migration status and occupation are associated with healthcare workers (HCW) redeployment experiences during COVID-19 in a nationwide ethnically diverse sample. Design A cross-sectional analysis using data from the nationwide United Kingdom Research Study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH) cohort study. Setting Healthcare settings. Participants Healthcare workers (HCW). Main Outcome Measures Outcome measures included redeployment, provision of training and supervision during redeployment, change in patient contact and interaction with COVID-19 patients. Methods We used logistic regression to examine associations of ethnicity, migration status, and occupation with redeployment experiences of HCWs. Results Of the 10,889 HCWs included, 20.4% reported being redeployed during the first UK national lockdown in March 2020. Those in nursing roles (Odds Ratio (OR) 1.22, 95% Confidence Interval (CI) 1.04–1.42, p = 0.009) (compared to medical roles) had higher likelihood of being redeployed as did migrants compared to those born in the UK (OR 1.26, 95% CI 1.06–1.49, p = 0.01) (in a subcohort of HCWs on the agenda for change (AfC) pay scales). Asian HCWs were less likely to report receiving training (OR 0.66, 95% CI 0.50–0.88, p = 0.005) and Black HCWs (OR 2.02, 95% CI 1.14–3.57, p = 0.02) were more likely to report receiving supervision, compared to White colleagues. Finally, redeployed Black (OR 1.33, 95% CI 1.07–1.66, p = 0.009) and Asian HCWs (OR 1.30, 95% CI 1.14–1.48, p < 0.001) were more likely to report face-to-face interaction with COVID-19 patients than White HCWs. Conclusions Our findings highlight disparities in HCWs’ redeployment experiences by ethnicity, migration, and job role which are potentially related to structural inequalities in healthcare.
Computational analysis of long QT syndrome type 2 and the therapeutic effects of KCNQ1 antibodies
Authors: Pan Zhujun , Fu Qi , Jiang Huasen , Wei Zhiqiang , Zhang Shugang 
Published: October 2024

Objective Long QT interval syndrome (LQTS) is a highly dangerous cardiac disease that can lead to sudden cardiac death; however, its underlying mechanism remains largely unknown. This study is conceived to investigate the impact of two general genotypes of LQTS type 2, and also the therapeutic effects of an emerging immunology-based treatment named KCNQ1 antibody. Methods A multiscale virtual heart is developed, which contains multiple biological levels ranging from ion channels to a three-dimensional cardiac structure with realistic geometry. Critical biomarkers at different biological levels are monitored to investigate the remodeling of cardiac electrophysiology induced by mutations. Results Simulations revealed multiple important mechanisms that are hard to capture via conventional clinical techniques, including the augmented dispersion of repolarization, the increased vulnerability to arrhythmias, the impaired adaptability in tissue to high heart rates, and so on. An emerging KCNQ1 antibody-based therapy could rescue the prolonged QT interval but did not reduce the vulnerable window. Conclusions Tiny molecular alterations can lead to cardiac electrophysiological remodeling at multiple biological levels, which in turn contributes to higher susceptibility to lethal arrhythmias in long QT syndrome type 2 patients. The KCNQ1 antibody-based therapy has proarrhythmic risks notwithstanding its QT-rescuing effects.
Promoting Social Participation in the Primary Care Field: An Ecological Study on the Potential Reduction of Multimorbidity Prevalence
Authors: Takahashi Ryota , Okada Tadao , Ide Kazushige , Tsuji Taishi , Kondo Katsunori 
Published: October 2024

Background: No municipal-level study has elucidated the social determinants associated with multimorbidity prevalence (MP). Objective: This article aimed to determine the differences in MP among municipalities and investigate factors associated with such differences through an ecological study of data obtained from a nationwide survey. This article focused on social participation and household income, which are associated with single chronic diseases, such as hypertension. Methods: Study design was a cross sectional study, which used the data from the Japan Gerontological Evaluation Study, a population-based gerontological study among functionally independent older adults aged ≥65 years in Japan. Overall, 152 212 participants from 2016 to 2017 across 91 municipalities were included in the final analysis. Multiple regression analysis was performed with MP as objective variable; social participation or household income were explanatory variables, and education, population density, and health check-ups were adjustment variables. Results: Intermunicipal differences in MP were 28.4% to 43.1% and 23.2% to 38.8% among men and women, respectively. Significant negative correlation was observed between MP and proportion of social participation (non-standardized coefficient [ B] = −.18 for men and women). A significant positive correlation was noted between MP and equivalent household income of ≤2 million yen in women ( B = .21). Conclusion: Considerable differences in MP existed among municipalities. Areas with high proportion of social participation showed significantly lower MP. Considering the difficulty in managing multimorbidity within the primary care field and limited evidence on effective interventions, community-level interventions encouraging social participation among older individuals might reduce MP. Primary care physicians should consider a community health approach for multimorbidity.
Psychosocial Work Factors, Job Stress, and Self-Rated Health Among Hotel Housekeepers
Authors: García-Buades M. Esther , Montañez-Juan Maribel , Blahopoulou Joanna , Ortiz-Bonnin Silvia , Chela-Alvarez Xènia , Bulilete Oana , Llobera Joan 
Published: October 2024

Background: Hotel housekeeping is widely recognized as a poor-quality job due to its high demands and limited resources. Hotel housekeepers (HHs) face both hard physical work and mentally demanding conditions, yet psychosocial factors in this feminized and precarious occupation remain under-researched. To address this gap, this study examines HHs’ exposure to psychosocial factors at work and their impact on job stress and self-rated health. Methods: A cross-sectional survey of a random sample of 926 HHs in the Balearic Islands (Spain) assessed job stress, self-rated health, psychosocial factors (job demands and resources), and sociodemographic variables using the Copenhagen Psychosocial Questionnaire II (COPSOQ-II) and the National Health Survey. Descriptive analysis and hierarchical linear regression models were applied. Results: The prevalence of job stress was 61.1% (95% confidence interval [CI] = [57.8%, 64.1%]), while the prevalence of poor self-rated health was 59.9% (95% CI = [56.6%, 62.9%]). Hotel housekeepers were highly exposed to job demands such as intense work pace, job-specific stressors, work–life conflict, and emotional demands; highly available job resources were role clarity, task meaning, and social support. Regression models revealed work pace, work–life conflict, nationality, and weak leader support as key predictors of job stress; and work–life conflict and leadership quality as key predictors of self-rated health. Conclusion/Application to Practice: Although considered an eminently physical job, psychosocial work factors play a key role in explaining HHs’ job stress and self-rated health. Occupational health professionals should design workplace interventions to reduce work pace, mitigate work–life conflict, and enhance resources such as leader support, sense of community, and leadership quality.
Meta-Analysis of Treatment for Adjacent Two-Segment Cervical Spondylotic Myelopathy: A Comparison Between Anterior Cervical Corpectomy and Fusion and Anterior Cervical Discectomy and Fusion
Authors: Chen Lei , Zhang Zhongyi , Li Ju , Tong Peijian , Xu Taotao 
Published: October 2024

Study Design A systematic review and meta-analysis comparing the outcomes of Anterior Cervical Discectomy and Fusion (ACDF) vs Anterior Cervical Corpectomy and Fusion (ACCF) in treating adjacent two-segment cervical spondylotic myelopathy. Objective To assess the clinical effectiveness and safety of ACDF compared to ACCF. Methods A literature search was conducted in Cochrane Library, Web of Science, PubMed, and Embase up to December 2023. Studies included were prospective and observational involving ACDF or ACCF for adjacent two-segment cervical spondylotic myelopathy. Data were analyzed using RevMan 5.4 software. Results Ten studies (nine case-control and one RCT) were included. ACDF showed a shorter hospital stay (SMD = −0.29, 95% CI: −0.53 to −0.04, P < 0.05), better Cobb angle (SMD = 0.52, 95% CI: 0.31 to 0.74, P < 0.01), and improved T1S (SMD = 0.54, 95% CI: 0.28 to 0.80, P < 0.01). No significant differences were found in upper limb VAS, neck VAS, JOA scores, NDI, fusion rates, C2-7 SVA, total complications, blood loss, and operation time. Conclusions ACDF and ACCF are both effective for adjacent two-segment cervical spondylotic myelopathy, with ACDF offering advantages in hospitalization duration and cervical curvature restoration, making it the preferred surgical approach. Further research is needed to validate these findings.
Long-term follow-up of the STOPAGO study
Authors: Cottu Adrien , Guillet Stéphanie , Viallard Jean-François , Rivière Etienne , Cheze Stéphane , Gobert Delphine , Neel Antoine , Graveleau Julie , Marolleau Jean-Pierre , Lefrere François , Moulis Guillaume , Lega Jean-Christophe , Moignet-Autrel Aline , Robbins Ailsa , Crickx Etienne , Boutin Emmanuelle , Noel Nicolas , Malphettes Marion , Galicier Lionel , Audia Sylvain , Bonnotte Bernard , Lambotte Olivier , Fain Olivier , Gerfaud-Valentin Mathieu , Terriou Louis , Martis Nihal , Morin Anne-Sophie , Perlat Antoinette , Le Gallou Thomas , Roy-Peaud Frédérique , Puyade Matthieu , Comont Thibault , Limal Nicolas , Languille Laetitia , Michel Marc , Godeau Bertrand , Mahevas Matthieu 
Published: October 2024

Abstract
In an open prospective, multicenter study enrolling 48 selected patients with chronic immune thrombocytopenia who achieved complete response for 1 year on thrombopoietin receptor agonists, half of the patients maintained a sustained response off treatment 4 years after treatment discontinuation.
Characteristics of attrition within the SuperMIX cohort of people who inject drugs: a multiple event discrete-time survival analysis
Authors: Abdelsalam Shady , Agius Paul A. , Sacks-Davis Rachel , Roxburgh Amanda , Livingston Michael , Maher Lisa , Hickman Matthew , Dietze Paul 
Published: October 2024

Abstract
Background
Compared to the general population, people who inject drugs have poor health and wellbeing. Longitudinal studies can provide insight into factors driving these worse health outcomes but are subject to methodological challenges, such as cohort attrition. The aim of this study was to assess and characterise attrition in a prospective cohort of people who inject drugs in Victoria, Australia.

Methods
Using annually collected self-reported data from The Melbourne Injecting Drug User Cohort Study (SuperMIX) from September 2008 to January 2021, we estimated the incidence of participants being lost-to-follow-up (LTFU), with an episode of being LTFU defined as participants not undertaking a follow-up interview within two years of their last interview. We utilised a multiple event discrete-time survival analysis on participant period-observation data to estimate the associations between key factors and LTFU. Key areas of exposure measurement in analyses were sociodemographic, drug use and mental health.

Results
A total of n = 1328 SuperMIX participants completed a baseline interview, with n = 489 (36.8%) LTFU, i.e. not completing a follow-up interview in the following two years. Increased attrition was observed among SuperMIX participants who were: born outside Australia, younger than 30 years, reporting having completed fewer years of education, not residing in stable accommodation, not in stable employment and not on opioid agonist therapy (OAT).

Conclusions
The attrition rate of the SuperMIX cohort has largely been stable throughout the duration of the study. Higher attrition rates among individuals at greater sociodemographic disadvantage and not on OAT suggest that additional efforts are required to retain these participants. Findings also suggest that SuperMIX might not be capturing data on adverse health and wellbeing outcomes among subpopulations at high risk of harm.
The association between dietary quality index- international and metabolic risk factors in RaNCD cohort study
Authors: Mokhtari Zahra , Abdollahzad Hadi , Izadi Neda , Rezaeian Shahab , Najafi Farid , Pasdar Yahya 
Published: October 2024

Abstract
Background
Non-communicable diseases (NCDs) are the leading cause of death around the world. The Dietary Quality Index-International (DQI-I) is one of the indicators that shows changes in diet and its association with NCDs. The aim of this study is to measure the association between the DQI-I and major metabolic risk factors.

Methods
This study is a cross-sectional study based on data collected in the first phase of the prospective cohort study on Ravansar non-communicable diseases (RaNCD). To perform clinical and biochemical tests such as lipid profile, blood glucose and liver enzymes, blood samples were collected using standard vacutainer blood collection techniques. Information from the food frequency questionnaire containing 118 food items was used to score each person’s DQI-I. Binary logistic regression was used to determine the association between the DQI-I tertile and the metabolic risk factors. Linear regression was also used for the association between subgroups of DQI-I score and the metabolic risk factors.

Results
The total number of subjects in this study was 7,115, with a mean age of 47.14 ± 8.29 years. Dietary quality was generally poor, with 37.03% in the lowest tertile. Men had better dietary quality than women. Anthropometric measures, blood pressure, triglycerides and blood glucose were lower in the lowest tertile of dietary quality. A one-unit increase in the total DQI-I resulted in a 0.19 decrease in total cholesterol. Higher dietary quality was associated with a 22% increased risk of high triglycerides, a 19% increased risk of low high-density density lipoprotein, a 5% decreased risk of elevated low-density lipoprotein, a 42% increased risk of high blood pressure, and a 99% increased risk of high fasting blood glucose. Higher dietary quality was also associated with a 33% increased risk of overweight/obesity.

Conclusion
The study found that participants had poor dietary quality, with some favorable metabolic outcomes in the lowest tertile, but concerning associations in the highest tertile, including increased risk for high triglycerides, blood pressure, and obesity. The complex associations suggest that balanced, multifaceted interventions are needed.
Impact of early cleft lip and palate surgery on maxillary growth in 5- and 10-Year-old patients with unilateral cleft lip and palate: a cross-sectional study
Authors: Novakova Magda , Brysova Alena , Vokurkova Jitka , Marcian Petr , Borak Libor , Koskova Olga 
Published: October 2024

Abstract
Objectives
This study evaluated maxillary growth and dental arch relationships at 5 and 10 years of age in patients with unilateral cleft lip and palate (UCLP) who underwent early cleft lip and palate surgery.

Methods
28 patients with UCLP who underwent cleft lip surgery in neonatal age and cleft palate surgery at average age of 7 months without orthodontic treatment (intervention group) were measured for intercanine and intermolar distances and for dental arch length. These measurements were compared with those of 30 healthy participants in a control group. Dental arch relationships in the intervention group were evaluated by 5-YO index at 5 years and the GOSLON Yardstick score at 10 years of patients’ age.

Results
Patients in the intervention group had significantly shorter mean intercanine distance and arch length than control patients at both 5 and 10 years of age (p&lt;.001 for all). There were no significant differences in intermolar distance at both 5 (p = .945) and 10 years (p = .105) of patients’ age. The average 5YO index increased from 2.46 to an average GOSLON 10-year score of 2.89 in intervention group.

Conclusion
Intercanine distance and dental arch length of patients with UCLP are significantly reduced at 5 and 10 years after early cleft lip and palate surgeries compared to the healthy population. Dental arch relationships at 5 and 10 years of patients with UCLP show comparable outcomes to those reported by other cleft centers.

Clinical significance
This study evaluates maxillary growth in UCLP patients 5 and 10 years of age who underwent early primary lip and palate surgery.