bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Optimal and Cost-Effective Artificial Lift System (ALS) Combination, Success Case Studies, and Cost Saving Assessment for RRP (Reciprocating Rod Pump) Wells in Oman
Authors: Naser Abuelfotouh A. 
Published: October 2024

Abstract
With continuous instability of oil prices, it became necessary to reduce the cost of lifting the crude oil from the wells. This cost reduction is not feasible for each stage of the total oil production system; therefore, the optimization of each component in the production system is a must.
The primary challenge is to extend the lifting equipment run life, especially the downhole components. For years, operators have been looking for reliable, flexible, and intelligent lifting systems to improve their operating costs, reservoir recovery factor by maximizing well production.
Production optimization meant to apply an optimum analysis and comprehensive investigation of well production system; including the artificial lift system that expected to increase the oil production and reduce the operating costs.
When producing difficult fluids from marginal, mature, and brown onshore oil fields, Sucker rod (Beam and Progressive Cavity) Pumping systems are typically the most common artificial lift methods used. The primary challenge is to extend the lifting equipment run life, especially the downhole components. Production optimization found to be an essential for the life cycle of each system to extend run life, decrease cost, and increase the cumulative production per well. High WC (90% & above), corrosive environment, sand production & scale build up resulted from water flooding effect are factors that result in harsh operating condition that dramatically affect downhole equipment lifetime & lead to premature failure.
In some of the fields premature failures resulted from harsh operating conditions are found close to 70% of total premature failure & 35% of total failures. The failures and problems related to Beam pumping (BP) and the success resulted from the applications of the system optimization has encouraged us to be selected to be the subject of this paper.
This presentation will discuss in full details the current downhole pump failures, challenges & plan of improving downhole pump metallurgy, configuration the application using latest technology in BP system. It will share different case histories and best practices from BP Wells by using actual well data and performance.
This topic can be summarized in: -
Heavy oil harsh well condition challenges & operational performance of beam pumping system in such these conditions. Solids & abrasives related failures investigation & solution planning Success stories maximizing pump efficiencies and minimizing failure rates of beam pumping system Cost saving impact after using solutions.
WITHDRAWN: Stock price prediction based on generative adversarial network
Authors: Zhou Yan , Lin Yuhao , Hu Zongliang , Song Bo , Tang Jianliang 
Published: October 2024

Abstract

The full text of this preprint has been withdrawn by the authors as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Difference in the efficacy of the modified-vaccinia Ankara vaccine as pre-exposure and post-exposure prophylaxis against sexual transmission of monkeypox virus clade IIb in non-human primates
Authors: Herate Cécile , Ferrier-Rembert Audrey , Relouzat Francis , GALLOUET Anne-Sophie , Pascal Quentin , Letscher Hélène , Cavarelli Mariangela , Bosquet Nathalie , Gros Wesley , Delache Benoit , Langlois Sébastien , Timera Hawa , Jarjaval Fanny , Bossevot Laëtitia , Ludot Camille , Brua Catherine , Ferraris Olivier , Silvestre Nathalie , Grand Roger Le , Tournier Jean-Nicolas 
Published: October 2024

Abstract

The monkeypox virus (MPXV) outbreak of 2022 caused a human disease with unusual epidemiological and clinical features, notably an increase in human-to-human transmission through sexual contact, predominantly among men who have sex with men (MSM). This evolution underscores the need to reassess prevention and control strategies in the context of a sexually transmitted disease. Here, we show that rectal challenge of cynomolgus macaques with a 2022 clade IIb MPXV isolate mimics sexual transmission, leading to rectal infection, with systemic and male genital tract dissemination and seminal fluid shedding. Vaccination with modified-vaccinia Ankara (MVA) protected the macaques from subsequent rectal MPXV challenge. However, MVA failed to prevent the disease when administered four days post-exposure to MPXV. These findings have a critical impact on outbreak management and highlight the importance of reevaluating MVA post-exposure prophylaxis protocols.
Global intensification of heat extremes has halved the abundance of tropical birds
Authors: Kotz Maximilian 
Published: October 2024

Abstract

Climate change is having widespread impacts on ecosystems worldwide, but the extent to which it may have already altered the abundance of major taxa remains unknown. Here, we show that the historical intensification of climate extremes has substantially reduced the abundance of terrestrial bird populations over the past five decades. Combining over 86,000 time-series observations of population abundance with exposure to locally defined climate extremes, we find strong and robust evidence that hot extremes reduce abundance growth, dominating the role of average temperature conditions or changes in precipitation. These impacts are largest in lower-latitude tropical regions and are robust when controlling for changing human pressure and the geographic and taxonomic bias of observed populations. Quantifying the portion of extreme intensification which is attributable to climate change implies substantial historical reductions in bird-abundance of up to 50% at low latitudes. These results provide new evidence that human-driven intensification of heat extremes is degrading the abundance of a major terrestrial vertebrate class, of particular relevance given hitherto unexplained declines of tropical birds in undisturbed habitats.
SARS-CoV-2 invasion dynamics based on genomic and geographic data: from Alpha to Delta and Omicron
Authors: Choi Yangji , De Ridder David , Ladoy Anaïs , Damien Jacot , Guessous Idris , Opota Onya , Bertelli Claire , Vuilleumier Séverine , Joost Stéphane , Greub Gilbert 
Published: October 2024

Abstract

The COVID-19 pandemic highlighted the need to understand the invasion dynamics of SARS-CoV-2 variants. Here, we investigate the successive invasions and geographical spread of three key variants of concern - Alpha, Delta, and Omicron - using an integrated dataset of genomics and geographic data from the canton of Vaud, Switzerland. We used a high-resolution dataset of 4,033 SARS-CoV-2 genomic sequences from PCR-positive cases between March 2020 and April 2022, accurately geocoded to residential locations. We identified genomic clusters with identical viral genomes and their number and size were larger for Omicron variant, confirming its distinct transmissibility. Invasion dynamics was well evidenced by the nucleotide diversity. Early in the invasion, nucleotide diversity was low and increased over time as variants diversified. New variant invasion was characterized by rapid increase in nucleotide diversity, due to co-circulation of old and new variants, followed by an abrupt decrease in diversity implying a complete replacement. A sharp increase and decrease of diversity within neighborhoods showed a rapid invasion of the Omicron across neighborhoods. We observed an exceptional peak of diversity within the same buildings during Omicron invasion, suggesting its stochastic transmission. This study supports the data-driven public health strategies to control and predict epidemics.
Superconductivity emerging from the Neel state in infinite-stage single-layer cuprate La2CuO4+δ
Authors: Ihara Yoshihiko , Sharma Ramender , Miyakoshi Kota , Oda Migaku , Ishida Kenji 
Published: October 2024

Abstract

The relationship between antiferromagnetism and superconductivity in copper oxide superconductors (cuprates) with single CuO2 conducting layer, e.g. La2-xBa(Sr)xCuO4, has been understood as a macroscopic phase separation when these phases appear in one sample. Here, we report compelling evidence that superconductivity occurs in a fully ordered Neel state as demonstrated by the 139La nuclear quadrupole resonance measurement for a single-layer cuprate La2CuO4+δ with small amount of excess oxygen δ = 0.015. Uniform oxygen distribution throughout the crystal is achieved as a crucial factor in realizing microscopic phase coexistence by surpassing the miscibility gap associated with the staging instability; self-organized periodic oxygen arrangement driven by mobile oxygen atoms.
This finding urges the reconsideration of the superconducting phase diagram of cuprates and the mechanism underlying at. While there are similarities with iron-based and heavy-Fermion superconductors for two-phase coexistence, the presence of sizable magnetic ordered moments in the Nel state sets La2CuO4+δ apart.
Retrieval from vacuolar/endosomal compartments underpinning neofunctionalization of SNARE in plants
Authors: Ueda Takashi , Feng Yihong , Ebine Kazuo , Ito Yoko , Kanazawa Takehiko , Sawasaki Tatsuya , Nozawa Akira , Uemura Tomohiro , Nakano Akihiko 
Published: October 2024

Abstract

The distinctive protein and lipid composition underlies the distinct function of each organelle, regulated by balanced anterograde and retrograde membrane trafficking. The vacuole, the largest plant organelle, is pivotal in various plant functions, with its protein composition tightly regulated by bidirectional trafficking. However, the existence of retrograde transport from the plant vacuole remained unverified. In this study, we demonstrate retrograde trafficking from the vacuole in Arabidopsis. We observed retrieval of VAMP727, a plant-unique vacuolar membrane fusion machinery, from the vacuolar membrane. VAMP727 retrieval is facilitated by SORTING NEXIN proteins, which were independently diversified between plant and non-plant systems. Furthermore, we show that the core retromer complex and SORTING NEXINs act independently in distinct retrograde transport events with specific cargos. Thus, plant cells have elaborated a unique retrieval mechanism from the vacuole, underpinning the neofunctionalization of VAMP727 during plant evolution.
The efficiency of anti-transpirants in the enhancement of the physiology of Rapeseed var. GSC-07 (Brassica napus L.) under different water stress levels.
Authors: Pakhira Arka , Jolly Gritta Elizabeth , Jincy M , Bag Animesh Ghosh 
Published: October 2024

Abstract

Rapeseed is a crucial crop in India, contributing 23.7% and 27% to oilseed acreage and production, respectively. With an estimated population of 1.32 billion, 21.12 million tonnes of edible oil are required, with about 20% to be met by rapeseed-mustard equivalent to 12.7 Mt. Water stress due to several factors is the limiting factor for increasing productivity. The main objective for performing this work is to evaluate the potential of anti-transpirants to study the underlying mechanism asserted by the anti-transpirants on the physiology of rapeseed. Three levels of stress were applied viz. Irrigation at 100% FC (Field Capacity), 75% FC and 50% FC. The research work was carried out in the agriculture field of Lovely Professional University. The experiment was carried out with 3 main plot treatments (Irrigation levels) and 5 sub-plot treatments (Anti-transpirants) carried out in three replications with 45 plots. The layout was split-plot design and statistical analysis was done using STATISTIX 10 and OPSTAT. After performing experiment, it has been observed that with increasing stress, reduced chlorophyll content, increased proline accumulation, and increased stomatal count per unit area of fresh leaf were observed. The least stress was observed due to the treatment of the crops with Kaolin 6% and as a result, lower proline accumulation, higher chlorophyll content, and lower stomata per unit area was observed. Plants treated with Kaolin 6% were observed to have higher nutrient (N, P and K) uptake. Whereas the same has been obtained in the crops treated with irrigation at 100% FC. The difference between the result obtained in irrigation at 100% FC and irrigation at 75% FC is less which indicates that increase in water availability was not too beneficial for the physiological development of the crop.
Spatio-temporal evolution of aeolian sand patterns in the Boulenouar Region, Mauritania: Insights from InSAR coherence and K-means Analysis
Authors: Deya Yaghoub Ahmed , Henoune Mohamed 
Published: October 2024

Abstract

This study combines Interferometric Synthetic Aperture Radar (InSAR) techniques with Sentinel-1B data and NASA's MERRA-2 reanalysis meteorological data to monitor the annual spatiotemporal evolution of aeolian processes in the arid region of Boulenouar, northwest Mauritania. Analysis of 31 SAR images acquired between February 2020 and February 2021 identifies three key areas affected by wind activity: a vast field of mobile barkhan dunes, the town of Boulenouar, and the surrounding road and rail infrastructure. Unsupervised k-means classification of coherence images shows that 19.4\% of the dunes are highly active. The study indicates an annual erosion rate of 3.84\% to the north and west, accompanied by a sedimentation rate of 15.56\% along transport axes and around Boulenouar. Correlated with NASA meteorological data, the analysis shows that wind activity is most intense in spring and summer. This study highlights the potential of coupling Sentinel-1 InSAR data with meteorological data to finely map wind dynamics in desert environments.
Association of Primary Tumor Volume with Survival in Patients with HER-2-positive Breast Cancer After Trastuzumab Treatment: A Retrospective Cohort Study
Authors: su pengcheng , Yang Dong , Li Jinlei , Wu Luyan , Wang Liyan , Cui Xiaofei , Li Xingxing , Ma Haoxia 
Published: October 2024

Abstract

Background:
The relationship between primary tumor volume (PTV) and overall survival (OS) in patients with human epidermal growth factor receptor 2 (HER-2)-positive breast cancer following Ttrastuzumab therapy remains controversial in the medical research community. Currently, there is insufficient evidence to definitively establish the relationship between PTV and OS; understanding this relationship is critical for healthcare and public health because it has significant implications for patient outcomes. Consequently, the PTV and its effects on OS have become the focus of extensive research.
Objective:
The primary objective of this study was to improve our understanding of the influence of PTV on OS and elucidate the clinical implications of this correlation. The secondary objective was to determine the optimal cutoff value for assessing the effect of PTV on OS in patients with HER-2-positive breast cancer after trastuzumab treatment.
Methods:
In this retrospective cohort study, we analyzed the data of 666 participants retrieved from the Dryad database. Relevant variables, including PTV, OS, lymph node status, Nottingham Histology Grading, Ki-67 expression, and age, were collected for all participants. We employed Cox regression analysis to explore the potential interaction effects to support our research objectives.
Results:
In total, 666 patients were identified during the follow-up period. The mean (standard deviation, SD) age of participants was 60.7 years, and all were women. The mean (SD) tumor volume was 19.9 (11.1) mm. With a mean (SD) follow-up of 82.4 (30.2) months, increasing tumor volume (per 1-mm increase) was associated with significantly worse adjusted OS (hazard ratio, 1.03; 95% confidence interval, 1.02–1.05).
Conclusions:
To the best of our knowledge, this extensive retrospective cohort study of patients with HER-2 positive breast cancer after trastuzumab treatment is the first to demonstrate a significant association between the PTV and a 3% increase in the risk of OS.
Understanding Delays in Breast Cancer Diagnosis: Insights from Bangladesh
Authors: Hossain Mohammad Sorowar , Trisha Sumaya Khan , Hasan Mohammad Nayeem , Akhter Waheed , Karim-Kos Henrike 
Published: October 2024

Abstract

Background
This study investigates factors contributing to delays in breast cancer diagnosis in Bangladesh and their impact on cancer staging. Early detection is crucial for effective treatment, yet many women in low- and middle-income countries (LMICs) are diagnosed at advanced stages, resulting in poorer outcomes.
Methods
A cross-sectional study was conducted at two major cancer care facilities in Dhaka. Women aged 18 and older with suspected or confirmed breast cancer were included. Data were collected using a structured questionnaire on sociodemographic and clinical variables. Total delay, defined as the time from symptom recognition to treatment initiation, was categorized into patient delay (symptom recognition to first medical consultation) and provider delay (first consultation to treatment start). Logistic regression analyses identified factors associated with these delays.
Results
Among 355 participants, 55.7% experienced total delays of over four months, with the highest delays in stage III cases (51.5%). Key factors contributing to patient delay included low education (Adjusted Odds Ratio [AOR]: 1.96, 95% CI: 1.04–3.74), low monthly income (AOR: 1.45, 95% CI: 1.22–1.90), and absence of breast pain (AOR: 0.55, 95% CI: 0.32–0.94). Provider delays were significantly associated with rural residence (AOR: 3.07, 95% CI: 1.49–6.98), and presence of nipple discharge (AOR: 2.92, 95% CI: 1.04–8.06). Total delays were most prevalent among patients from the Rangpur division (AOR: 6.07, 95% CI: 1.76–8.02), rural areas (AOR: 2.04, 95% CI: 1.17–3.61), and those with lower education. Additionally, nearly 80% of patients delayed seeking medical attention due to the belief that symptoms would resolve spontaneously, while 75% cited negligence and 65.5% reported financial barriers.
Conclusions
Significant delays in breast cancer diagnosis in Bangladesh are driven by socio-economic factors and inadequate healthcare access. Increasing public awareness, especially in rural areas, and improving healthcare accessibility are essential to facilitate early detection. Expanding screening programs and training healthcare providers in early cancer detection are critical to improving patient outcomes.
Socioeconomic determinants of access to safe abortion and experiences along the care trajectory: A survey of women with a five-year abortion history in Abuja and Lagos, Nigeria
Authors: Roemer Matthea , Ushie Boniface Ayanbekongshie , Akiode Akinsewa , Onuoha Ogechi , Idoko Ochanya , Taiwo Anne 
Published: October 2024

Abstract

Background:
Unsafe abortion remains a significant cause of maternal morbidity and mortality in many African countries, including Nigeria. There is limited evidence on abortion safety or experiences of abortion care in Nigeria. This study aims to fill gaps in understanding of how abortion safety has evolved since previous estimates and provide new insight on pregnant people’s experiences along the abortion care trajectory and how sociodemographic factors correlate with these experiences and the overall safety of abortion.
Methods:
Data presented are drawn from a larger study that was conducted in Lagos and Abuja, Nigeria in 2023 using a total market assessment approach. This analysis drew exclusively on data from a quantitative survey of women of reproductive age with a 5-year history of induced abortion(s). Abortion safety was operationalised based on two dimensions in line with a previous analysis of Nigeria PMA survey data: (1) whether the method(s) used included any non-recommended methods and (2) whether the source(s) used were clinical or non-clinical. Analyses include frequencies of abortion safety and experiences along the abortion care trajectory and bivariate and multivariate assessments of sociodemographic and reproductive history correlates.
Results:
Two hundred women completed the survey of which 197 reported their abortion method and were included in this analysis. Almost half (44.7%) of respondents’ reported abortions were categorised as most unsafe involving non-recommended methods and non-clinical source(s). Those living in rural areas and those who were living in severe poverty were significantly more likely to have had the most unsafe abortions. Those living in poverty were also at increased likelihood of being unable to access an abortion from their preferred source and of experiencing any complications.
Conclusion:
These findings confirm that abortion in Nigeria is a public health concern and an issue of social inequity. Efforts to improve equitable access to in-facility services, particularly surgical procedures and post-abortion care is critical to ensure management of complications from unsafe abortion. Simultaneously, increasing awareness of the availability of quality-assured medication abortion drugs for self-management and/or training of lower-level providers on management of medical abortion can help mitigate the toll of unsafe abortion-related morbidity and mortality.
How fragile are European GVCs? The role of functional diversification and implications for industrial policy
Authors: Coveri Andrea , Giammetti Raffaele , Zanfei Antonello 
Published: October 2024

Abstract

This paper examines the relationship between functional diversification and foreign input reliance (FIR) in European countries, with a focus on manufacturing sectors. We propose that greater functional diversification is a key strategy to soften dependency on foreign inputs, thereby mitigating the risks associated with Global Value Chain (GVC) disruptions. We elaborate on recently developed indicators for GVC exposure based on international gross trade flows and test their association with a novel measure of functional diversification, proxied with data on Foreign Direct Investments (FDIs) across value chain activities. Our findings reveal that functional diversification is negatively associated with FIR, particularly from extra-EU28 sources, indicating that European countries can reduce exposure to GVC disruptions by diversifying value-adding functions. However, this relationship is also found with reference to the intra-EU FIR component, suggesting that functional diversification strategies undertaken at the level of individual member states may end up weakening European trade integration. We conclude that the EU’s Open Strategic Autonomy framework should carefully consider coordinated industrial strategies to strengthen the EU’s capacity to navigate GVC disruptions without undermining intra-EU trade ties.
Enhancing Network Intrusion Detection Using GraphConvolutional Networks Fused with Traditional Systems
Authors: Ansah Patrick , John Caroline , Tetarave Sumit Kumar , Kalaimannan Ezhil 
Published: October 2024

Abstract

In the ever-evolving landscape of network security, effective intrusion detection is paramount.The detection of anomalies in network systems is very vital to the safety of data as well asthe privacy of individuals. This research presents an advanced approach to network intrusiondetection by incorporating Graph Convolutional Networks (GCN). We propose two novel mod-els: a GCN-Autoencoder (GCN-AE) for unsupervised anomaly detection and a GCN-basedk-Nearest Neighbors (GCN-KNN) for supervised intrusion classification. Utilizing a balanceddataset extracted from the UNSW-NB15 dataset, which includes a diverse range of modern net-work activities and cyber-attacks, our models exploit the underlying graph structure of networkdata to enhance detection capabilities. The imbalanced dataset consists of 49 features and 700,000instances including standard network traffic metrics such as duration, protocol type, service,source bytes, and destination bytes which help to gain deeper insights into complex attacks. TheGCN-Auto-encoder performed at 52.86% whereas the GCN-KNN performed at 99.94% with thebalanced dataset.