bluuebunny/crossref_metadata_2025_split huggingface dataset:
EURAMET cg-18 – state-of-the-art calibration guideline for non-automatic weighing instruments
Authors: Fritsch Klaus 
Published: September 2019

<p> </p><p class="Abstract">This paper presents a state-of-the-art strategy for calibrating non-automatic weighing instruments (NAWIs), based on the international calibration guideline EURAMET cg-18. While existing national and legacy guidelines have only dealt with measurement uncertainty at the time of calibration, EURAMET cg-18 also provides advice for the so-called uncertainty of a weighing result, which describes the device performance during day-to-day usage. Furthermore, as a consequence of the uncertainty of a weighing result, the concept of minimum weight is introduced. The minimum weight is the smallest amount of mass that must be weighed on the device while still adhering to a predefined relative weighing tolerance requirement. The concept of minimum weight is the most important practical and quality relevant implication of NAWI calibration, as it is the prerequisite to achieve the necessary accuracy commensurate with the quality requirements of the weighing process.</p><p><span style="font-family: Calibri; font-size: small;"><br /></span></p>
Calibration values uninfluenced by the kind of pressure medium and the setting posture for quartz Bourdon-type pressure transducers
Authors: Iizumi Hideaki , Kajikawa Hiroaki , Kobata Tokihiko 
Published: September 2019

<p class="Abstract">The effects of the kind of gas medium and the setting posture on the calibration values of a quartz Bourdon-type pressure transducer mounted vertically are evaluated in this study. The transducer, at the upward and downward settings, was calibrated both with nitrogen and with helium. The difference between the calibration values of the transducer with nitrogen at the upward and downward settings was about 7.0 kPa at 100 MPa. At the same setting posture, the maximum difference in the calibration values between nitrogen and helium was 3.4 kPa. For precise pressure measurement, it is recommended that the transducers are used with the same pressure medium and the same setting posture with which they were calibrated. The methods of reducing the effects of both the kind of gas medium and the setting posture are discussed. The average of two calibration values at the upward setting and at the downward setting was not affected by the kind of gas medium. When the sensing elements of two pressure transducers arranged in point symmetry with each other, the average values of two transducers were independent of both the kind of gas medium and the setting posture.</p>
Peranan Sistem Informasi Akuntansi dan Tantangan Profesi Akuntan di Era Revolusi Industri 4.0 (Sebuah Studi Fenomenologi)
Authors: Cahyadi Iwan Fahri 
Published: September 2019

<p><em>In the last few years appeared a variety of breakthrough technology that generates new values in human life through a form of artificial intelligence, data, internet of things (IoT). Business circles call the third it as the core of the industrial revolution 4.0. These conditions have an impact on the role of the human being, particularly the challenges of the profession of accountants who will be replaced by the role of the robot. The purpose of this research is to provide a solution so that the role of the accountants still exist in the era of the industrial revolution 4.0. As for qualitative research methods via the fenomenalogi approach i.e. we allow qualitative researchers implement and apply subjective abilities and exploratory process in interpersonalnya. Results of the study so that the accountant still exist in the era of the industrial revolution 4.0 then the accountant to start learning programming and algorithms to be able to adapt to change, if you don't use the technology, then the role of the accountant will be replaced by robots.</em></p>
Evaluation of an online, real-time, soft-photon ionisation time-of-flight mass spectrometer for mainstream tobacco smoke analysis
Authors: Hawke Jenni , Errington Graham , von Frowein Matthias Bente 
Published: September 2019

Abstract
Mainstream tobacco smoke is a complex and dynamic aerosol, consisting of particulate and vapour phases. Most approaches to determine mainstream smoke toxicant yields are based on offline techniques that limit the opportunity to observe in real time the processes leading to smoke formation. The recent development of online real-time analytical methods offers many advantages over traditional techniques. Here we report the LM2X-TOFMS (Borgwaldt GmbH, Germany), a commercial instrument that couples a linear smoking engine with a time-of-flight mass spectrometer for real-time per-puff measurement of the vapour phase of mainstream cigarette smoke. Total cigarette and puff-by-puff (μg/puff) yields were evaluated, in line with International Council of Harmonisation recommendations, for seven smoke toxicants: acetaldehyde, acetone, 1,3-butadiene, 2-butanone, benzene, isoprene and toluene. Measurements were unaffected by small system changes including replacing the sampling capillary or time of day (all P>0.05), indicating that the LM2X-TOFMS is rugged. Control charts showed that the system has good stability and control. Analysis of certified gas mixtures of six concentrations of each analyte showed a highly linear response for all seven analytes (R2=0.9922–0.9999). In terms of repeatability, the lowest variation was observed for isoprene with a coefficient of variation (CV) of <6% for each concentration. Acetaldehyde showed the highest CV, increasing from 8.0% to 26.6% with decreasing gas concentration. Accuracy was analysed in terms of relative error, which was ±16% for six of the analytes; however, the relative error for acetaldehyde was (–36.2%), probably due to its low ionisation efficiency under the instrument’s vacuum ultraviolet lamp. Three cigarette products (reference and commercial) with different ISO tar levels were analysed by the LM2X-TOFMS puff by puff under ISO regulatory smoking conditions. The relative standard deviation based on average yield per cigarette for each analyte in each product (summed puffs per product, n=30) ranged from ≤9.3% to ≤16.2%. Measurements were consistent with published data per cigarette. In conclusion, the LM2X-TOFMS is suitable for determining the vapour-phase yields of seven analytes on a real-time, puff-by-puff basis, and can be utilised for both fast screening (qualitative) and quantitative measurements of mainstream cigarette smoke.
Direct-acting antiviral agents in the treatment of chronic Hepatitis C – Real-life experience from clinical practices in Pakistan
Authors: Mushtaq Saima , Mansoor Atika , Siddiqi Saima , Khan Amjad , Manzoor Sobia 
Published: September 2019

Abstract
Background: This study aims to evaluate the clinical effectiveness in terms of sustained virological response (SVR), predictors of SVR and safety of available second generation generic direct-acting antivirals in Pakistani chronic Hepatitis C patients.Methods: This is a retrospective study conducted in multiple centers of Pakistan from January 2015 to January 2019. The samples include patients infected with chronic hepatitis C virus, regardless of virus genotype, cirrhosis, or prior treatment. Statistical analysis was performed to compare the effectiveness among the direct-acting antiviral agents (DAAs) based treatments and also to reveal the factors influencing the achievement of SVR.Results: A total of 993 patients were included in the present study, with the majority receiving sofosbuvir with daclatasvir (95%), sofosbuvir with daclatasvir and ribavirin (4%) and sofosbuvir with ribavirin (1%). There were 96% cases of chronic hepatitis, 3% cases compensated cirrhosis and 1% cases of decompensated cirrhosis. Genotype 3 (99.6%) was the most common genotype. Overall SVR after 12 weeks was 98% for all treatment regimens. High SVR12 was observed with sofosbuvir in combination with daclatasvir (98.5%), then sofosbuvir in combination with daclatasvir and ribavirin (90.2%) and sofosbuvir in combination with ribavirin (75%). SVR rates were high in CHC patients (98.2%) as compared to cirrhotic patients (92.1%) and it was high in treatment naive (98.8%) then IFN experienced patients (90.1%). In multivariate binary logistic regression analysis, patients’ education status, treatment strategy, viral load and ALT had statistically significant association with SVR at 12 weeks. No major adverse events occurred which required treatment discontinuation. Conclusion: Generic oral DAAs (sofosbuvir with daclatasvir) achieved higher SVR12 rates and were well tolerated in this large real‐world cohort of genotype 3 infected patients.
Genome description and inventory of immune-related genes of the endangered pen shell Pinna nobilis: a giant bivalve experiencing a mass mortality event
Authors: Bunet Robert , Prévot Jean-Marc , Vicente Nardo , García-March José Rafa , Martinović Rajko , Tena-Medialdea José , Joksimovic Danijela , Bonnefont Jean-Luc , Coupé Stéphane 
Published: September 2019

Abstract
Background: The noble pen shell Pinna nobilis is a Mediterranean endemic and emblematic giant bivalve. Already registered as an endangered species in the late 20th century, it is facing a dramatic and rapidly expanding epizooty that decimates its populations since mid-2016. The ecological value of P. nobilis has urged important investigations for conservation purposes. In light of this, we report here the first draft genome of this animal. Results: The whole-genome sequencing has been performed on an Illumina HiSeq X platform using a single paired-end library of short fragments (2x150 bp). The de novo contig assembly accounted for a total size of 584 Mb (96,738 contigs, N50 = 7.6 kb, with 0.4% of “N” nucleotides), representing 77.5% of the predicted genome size of 754 Mb. The pen shell genome is very AT-rich, with a GC-content of 35.6 %. Heterozygosity was found to be in the range of other sequenced bivalves (1%). Over one third (36.2 %) of the genome consisted of repeated elements with a surprising larger number of SINEs elements compared to other molluscan genomes. We were also able to reconstruct the full mitochondrial genome (~19 kb, with 12 protein-coding genes, 2 rRNA and 22 tRNA genes). In relation with the outbreak that affects P. nobilis, we paid a special attention on the innate immune and stress-related genes found in the sequence. We revealed that P. nobilis disposes of a complete chemical defensome, and a relatively sophisticated innate immune system. Conclusion: In addition to offering a valuable resource for further research in comparative biology and evolution, access to the draft genome sequence is central to deepen our understanding of the vulnerability of P. nobilis to new diseases, which are likely to occur more often in the current scenario of a rapidly changing environment.
A novel 20-gene prognostic score in pancreatic adenocarcinoma
Authors: Canli Secil Demirkol , Dedeoglu Ege , Akbar Muhammad Waqas , Kucukkaraduman Baris , Isbilen Murat , Erdogan Ozge Sukruoglu , Erciyas Seda Kilic , Yazici Hulya , Vural Burcak , Gure Ali Osmay 
Published: September 2019

Abstract
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Known risk factors for this disease are currently insufficient in predicting mortality. The only FDA approved prognostic biomarker for PDAC patients is CA19-9. This, along with AJCC TNM staging and performance status, are considered important prognostic indicators in clinical practice. In order to better prognosticate patients with PDAC, we identified a novel panel of genes by utilizing publically available microarray and RNAseq data of PDAC tumors from GEO and TCGA. Expression of 20 genes were significantly associated with overall survival in four datasets and event-free survival in TCGA. A score generated based on the expression matrix of these genes could be validated in two independent cohorts. We find that this “Pancreatic cancer prognostic score 20 – PPS20” is dramatically elevated in metastatic tissue compared to primary tumor, and is higher in primary tumors compared to normal pancreatic tissue. Transcriptomic analyses show that tumors with low PPS20 have overall more immune cell infiltration and a higher CD8 T cell/Treg ratio when compared to those with high PPS20. Analyses of proteomic data from TCGA PAAD indicated higher levels of Cyclin B1, RAD51, EGFR and a lower E-cadherin/Fibronectin ratio in tumors with high PPS20. The PPS20 score defines not only prognostic and biological sub-groups but can predict response to targeted therapy options as well. Overall, PPS20 is a stronger and more robust transcriptomic signature when compared to similar, previously published gene lists.
A Pilot Evaluation of Magnetic Resonance Imaging Characteristics Seen With Primary Soft Tissue Giant Cell Tumor in 2 patients
Authors: Zhang Lina , Kang Jianyun , Zhang Kai , Liu Ailian , Wang Huali , Liu Tieli 
Published: September 2019

Abstract
Background Primary soft tissue giant cell tumor (GCT-ST) is a rare tumor with low malignant potential. Here we reported two cases of patients with soft tissue giant cell tumor in the limb, including their clinical and imaging findings (conventional Magnetic resonance imaging (MRI) and Diffusion weighted imaging (DWI)).Methods This retrospective study included two pathology-confirmed GCT-ST patients. Plain MRI, dynamic contrast enhancement MRI (DCE-MRI), and DWI were performed with a 3.0T whole-body MR scanner before surgery. The following characteristics of lesion were recorded: signal intensity on T 1 FSPGR and T 2 WI, morphology, maximum lesion size, time intensity curve (TIC) on DCE-MRI, and apparent diffusion coefficient (ADC) value from DWI.Results The maximum lesion size ranged from 4.0 cm to 6.0 cm. Signal intensities of all lesions were heterogeneous on T 1 FSPGR and T 2 WI. Nodular enhancements were observed for all lesions with either oval or irregular shapes on MRI. All lesion margins were blurred, and internal enhancements were heterogeneous on DCE-MRI. TIC appeared with a slow increase type. Lesions on DWI (b=500s/mm 2 ) were hyperintense with an higher mean ADC value of 2.19×10 −3 mm 2 /s compared to surrounding normal soft tissue (1.03×10 −3 mm 2 /s).Conclusions DWI may be a useful tool for differentiating benign soft tissue mass from giant cell-rich soft tissue neoplasms or malignant tumors.
Long-term survival trends in patients with unresectable stage III non-small cell lung cancer receiving chemotherapy and radiation therapy: a SEER cancer registry analysis
Authors: Hansen Ryan N , Zhang Yiduo , Seal Brian , Ryan Kellie , Yong Candice , Darilay Annie , Ramsey Scott D 
Published: September 2019

Abstract
Background: To evaluate the value of new therapies for non-small cell lung cancer (NSCLC), it is necessary to understand overall survival (OS) rates associated with previous standard therapies and how these rates have evolved over time.

Methods: We retrospectively analyzed data from patients enrolled in the Surveillance, Epidemiology, and End Results (SEER) cancer registry. Adults with unresectable, stage III NSCLC treated with chemoradiotherapy were grouped by diagnosis year (2000–2002; 2003–2005; 2006–2008; 2009–2011; 2012–2013). The primary endpoint was OS (data cut-off, December 31, 2014), estimated using the Kaplan–Meier estimator. Temporal survival-trend significance was tested using a two-sided log-rank trend test.

Results: Of 12,865 eligible patients, 59.1% were male, 59.9% had stage IIIB disease, and 62.7% had non-squamous histology. Median age at diagnosis was 67 years. Overall, 10,899 (84.7%) patients died and 1,966 (15.3%) were censored/lost to follow-up. Median follow-up (95% confidence interval [CI]) was 80 (77–82) months; median OS (95% CI) was 15 (15–16) months; 1- and 3-year survival probabilities (95% CI) were 57.7% (56.9–58.6) and 24.1% (23.3–24.8), respectively. Stratification by diagnosis year showed consistent improvements in survival over time ( p < 0.0001 for trend). Median OS was 12, 14, 15, 18, and 19 months in successive cohorts.

Conclusions: OS in patients diagnosed with unresectable, stage III NSCLC between 2003 and 2013 was consistent with that from clinical studies of sequential/concurrent chemoradiotherapy. Despite improvement over time, median OS was <2 years and mortality remained high during the first year post-diagnosis.
Overexpression of Cyclooxygenase-2 predicts poor survival of patients with nasopharyngeal carcinoma: A meta-analysis.
Authors: Sim Edmund Ui Hang , Sim Chor-Chien , Chong Yee-Ling 
Published: September 2019

Abstract
Background The prognostic significance of cyclooxygenase-2 ( Cox-2 ) expression has been implicated in various cancers such as carcinomas of the breast, head and neck squamous cell, oral squamous cell, and nasopharyngeal. Despite meta-analysis studies of Cox-2 expression in Head and Neck cancer, similar investigation that focus on nasopharyngeal carcinoma (NPC) remains unexplored. Thus far, expression studies of Cox-2 in NPC have not yield conclusive findings due to conflicting results. This study, therefore, is the first to evaluate Cox-2 expression with the survival outcome and treatment response of NPC patients via a systematic meta-analysis approach.Methods Meta-analysis was done in compliance with the standard protocol of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Checklist. Potential studies were obtained from PubMed, Science Direct and Scopus. Fundamental and primary clinical characteristics of patients and hazard ratios (HRs) with 95% confidence intervals (CIs) of overall survival (OS) data were then collected and tabulated. Analysis of relationship between Cox-2 expression and survival outcome in NPC patients were explained with the aid of forest plot charts. Odd ratio (OR) evaluation to determine the relationship between Cox-2 expression and treatment response was via MedCalc (version 18.11) software, with results displayed in forest plots.Results Seven eligible studies containing 495 NPC patients were finally used in the meta-analysis. The pooled HRs with 95% confidence intervals (CIs) for OS is 2.53 [2.13, 3.27], indicating that overexpression of Cox-2 corresponds to poor survival. In the case of treatment response, the pooled OR is 0.98 [0.27-3.49], revealing that the expression pattern of Cox-2 did not relate to the outcome of treatment.Conclusions Overexpression of Cox-2 predicts worse survival outcome for NPC patients, but not treatment response. Hence, the prognostic value of Cox-2 in NPC is only relevant when survival probability of patients is considered.
R248Q mutation of p53 alters molecular trafficking and targeted drug responses in high-grade serous ovarian carcinoma
Authors: Tsai Kai-Yun , Lai Zih-Yin , Chang Shing-Jyh , Chuang Yung-Jen 
Published: September 2019

Abstract
Background p53 mutations are detected in up to 96% of high-grade serous ovarian carcinoma (HGSOC). Moreover, mutant p53 may cause oncogenic gain-of-function phenotypes in sustained activation of epidermal growth factor receptor (EGFR) signaling. In this study, we investigated whether p53 mutation could affect EGFR-related signaling and the corresponding therapeutic strategies in HGSOC.Methods For this study, we selected the p53 R248Q mutant (p53 R248Q ), which has the highest mutation frequency in ovarian cancer. Since we have previously demonstrated that the combined inhibition of EGFR and MDM2-p53 pathways by gefitinib and JNJ-26854165 exerts a strong synergistic lethal effect on p53-mutated HGSOC cells, the gefitinib and JNJ-26854165 responses in different p53 status cells were evaluated by cell viability and target protein expression assays.Results We showed that the phosphorylation of AKT, a critical molecule of EGFR downstream signaling, increased significantly when p53 R248Q was transiently overexpressed. Immunocytochemistry analysis further showed that upon p53 R248Q overexpression, several AKT-dependent mediators translocate in unique patterns within the cell. Subsequent analysis revealed that under the combined inhibition of gefitinib and JNJ-26854165, the cytonuclear trafficking of EGFR and MDM2 is disrupted. Moreover, when we further compared gefitinib and JNJ-26854165 responses in different p53 status cells, we found that the sensitivity to the single- or combined-inhibition treatments is also altered in p53 R248Q -overexpressing cells.Conclusions Our findings suggest that the R248Q mutation of p53 causes significant changes in signaling transduction, molecular trafficking and drug responses, which help to advance our understanding of p53 and to improve therapeutic strategies for HGSOC.
Resilience as a mediator of interpersonal relations and depression amongst 10th to 12th grade students
Authors: Lee Tony Szu-Hsien , Wu Ying-Jhen , Chao En , Chang Chun-Wei , Zhan Wang , Wu Wen-chi 
Published: September 2019

Abstract
Background: This study aims to explore the prevalence of depression and examine if resilience is a mediator between interpersonal relationships and depression in senior high school students. Methods: Of 463 randomly selected participants from 3,900 high school students in a high school, 450 (97.19%) consented and completed the structured questionnaire which consisted of 4 parts: Demographics, Inventory of Adolescent Resilience, Taiwan Relationship Inventory for Children and Adolescents, and Center for Epidemiologic Studies Depression Scale for Children. Results: A total of 94 (20.89%) had depression, out of which 54 (24%) were boys and 40 (17.78%) were girls. Results from the path analysis indicated that resilience and interpersonal relationships were negatively associated with students' depression, and interpersonal relations were partially mediated by resilience to depression after controlling for demographics. Conclusion: Findings support that resilience and better interpersonal relations are protective factors for depression in adolescents. Findings also suggest that better interpersonal relationships can boost resilience to alleviate depression amongst adolescents.
Personality traits of Lebanese patients with schizophrenia: Comparison by gender and severity of psychosis
Authors: Dib Joseph E , Haddad Chadia , Nehme Ilige , Azar Jocelyne , Seddik Ghina Al , Hallit Souheil , Obeid Sahar 
Published: September 2019

Abstract
Objectives Schizophrenia is known as a mental disease affecting how an individual will reply to a certain scenario in a way that differs from a person to another. A specific personality trait can influence the expressions of psychotic symptoms and affect illness courses. Our aim during this study was to spot nonadaptive personality traits in Lebanese Schizophrenic patients and compare them to healthy subjects.Methods We took a pair of teams one schizophrenic individuals (n=250) and the other healthy individuals (n=250). For the data assortment the tools used were: personality inventory for the DSM-5 (PID-5-BF) brief type, to assess the maladaptive personality traits; Positive and Negative Syndrome Scale (PANSS), to determine the severity of psychotic symptoms in schizophrenic individuals.Results The results were a considerably higher mean in detachment, antagonism and psychoticism personality traits in schizophrenic subjects compared to healthy group. When comparing personality based on the gender a considerably higher mean of negative affect and psychoticism was found in women compared to men, as for the antagonism and detachment it had been considerably higher in men.Conclusion In conclusion, we can say that schizophrenic subjects have a particular personality trait totally different from the overall healthy subjects.