bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the Economic Ripple Effect of the United States on the World due to Future Climate Change
Authors: Zhang Zhengtao , Li Ning , Xu Hong , Chen Xi 
Published: May 2018

AbstractSolomon Hsiang's study, which was recently published in Science, has caused extensive discussion by indicating that future climate change may exert influences on the agricultural yield, labor supply, and energy demand, among others of the United States. Based on the above study, we use an optimized input‐output model to evaluate the economic ripple effect (ERE) of the United States on the world due to climate change under Representative Concentration Pathway 4.5 with different increases in the annual mean temperature (AMT; 1, 1.5, and 2°C) between 2020 and 2100. The results show that if a loss of gross domestic product of 0.88% occurs with a 1°C AMT increase in the United States, the ERE of approximately 0.12% will be generated onto the global gross domestic product; with a 2°C increase, the ERE will triple. The time variation trend of the ERE conforms to the future variations in AMT. The degree of this effect on other regions of the world is closely related to the trade links between the United States and economic aggregates. Among these regions, Canada shows the greatest impact, followed by China. The ERE that China suffers may increase by 4.5 times as the AMT in the United States increases from 1 to 2°C. In cold regions, the benefit from global warming will decrease due to the ERE from other regions, which will inhibit their economic development. This paper aims to provide new perspectives and data‐based support for regions around the world to cope with climate change and to develop policies by studying the ERE behind international trade.
Effects of Oblique Wave Normal Angle and Noncircular Polarization of Electromagnetic Ion Cyclotron Waves on the Pitch Angle Scattering of Relativistic Electrons
Authors: Lee Dae‐Young , Shin Dae‐Kyu , Choi Cheong‐Rim 
Published: May 2018

AbstractElectromagnetic ion cyclotron (EMIC) waves have long been considered major plasma waves that can cause the atmospheric precipitation of electrons. In this work, we perform test particle calculations of the interactions between relativistic electrons and EMIC waves with oblique wave normal angle (WNA) and noncircular polarization. We demonstrate advective and diffusive changes in electron pitch angle (PA) under a uniform background magnetic field for broad ranges of kinetic energy (KE), PA, WNA, and ellipticity. First, we find that the direction of advective PA changes can be of either sign, being positive (negative) for a lower (higher) initial PA. Second, an oblique WNA can enhance the advection effects on PA changes, particularly for KE ~2.5–4 MeV and a broad range of initial PAs. In contrast, a more linear polarization can decrease advection for a broad range of KE and initial PAs. Third, phase space trajectories depend strongly on specific values of WNA, ellipticity, KE, and PA. Sometimes a phase‐averaged PA change is a net result of a time‐dependent mixture of the phase trapping, untrapping, and bunching effects. Lastly, the overall effect of finite WNA and ellipticity on diffusive PA changes is less systematic than on advection. Nevertheless, we identify a range of KE and PA where the diffusion tends to increase for a larger WNA and decrease for a more linear polarization. The results in this work emphasize a strong necessity for incorporating precise information on WNA and ellipticity into evaluations of electron scattering by EMIC waves.
Antarctic Cloud Macrophysical, Thermodynamic Phase, and Atmospheric Inversion Coupling Properties at McMurdo Station: I. Principal Data Processing and Climatology
Authors: Silber Israel , Verlinde Johannes , Eloranta Edwin W. , Cadeddu Maria 
Published: May 2018

AbstractPolar cloud radiative forcing plays a crucial role in the determination of the surface and atmospheric energy balance through processes which are not yet fully understood. While there is a broad and fairly complete database of cloud measurements from several Arctic sites and field campaigns through the past two decades, the recent one‐year long U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) West Antarctic Radiation Experiment (AWARE) field campaign at McMurdo Station has provided a hitherto unmatched multiple‐instrument set of ground‐based Antarctic cloud measurements. These observations are processed and used to derive the main cloud and liquid containing layer properties: occurrence fraction, cloud persistence and boundaries, and configuration relative to temperature and moisture inversions. The results are compared to previous Arctic observations. It is concluded that clouds and liquid‐bearing layers over McMurdo Station are essentially less prevalent and persistent than their Arctic counterparts. However, they typically have higher bases and show a weaker temperature dependence than in the Arctic, suggesting a more “pristine” Antarctic atmosphere. In addition, the clouds (including both water phases) typically extend toward relatively lower altitudes, and their relation to inversions near cloud top is often similar to those observed in the Arctic.
Neutrophil extracellular traps promote macrophage pyroptosis in sepsis
Authors: Chen Linsong , Zhao Yanfeng , Lai Dengming , Zhang Peng , Yang Yang , Li Yuehua , Fei Ke , Jiang Gening , Fan Jie 
Published: May 2018

AbstractIn response to infection, polymorphonuclear neutrophils (PMN) are recruited in the infectious sites, and employ three major strategies to fight against the microbes including phagocytosis, degranulation, and neutrophil extracellular traps (NETs). NETs are a meshwork of chromatin fibers mixed with granule-derived antimicrobial peptides and enzymes, which trap and kill the bacteria extracellularly. In this study, by using a mouse sepsis model, we identified a novel mechanism by which NETs induce macrophage (Mϕ) pyroptosis, a caspase-1-dependent regulated cell death. We show that NET-derived HMGB1, acting through RAGE and dynamin-dependent signaling, triggers an intra-Mϕ cascade of molecular events including cathepsin B (CatB) release from the ruptured lysosomes, followed by pyroptosome formation and caspase-1 activation, and subsequent Mϕ pyroptosis. The study further demonstrates that Mϕ pyroptosis augments inflammatory responses following sepsis. These findings shed light on the proinflammatory role of NETs in mediating PMN–Mϕ interaction, which therefore influences the progress of inflammation following infection.
The novel KLF4/PLAC8 signaling pathway regulates lung cancer growth
Authors: Jia Yunlu , Ying Xiaogang , Zhou Jichun , Chen Yongxia , Luo Xiao , Xie Shudu , Wang Qin chuan , Hu Wenxian , Wang Linbo 
Published: May 2018

AbstractAccumulating evidence suggests that placenta-specific 8 (PLAC8) plays an important role in normal cellular process and human diseases, including multiple types of human tumors, and its role is highly relied upon in cellular and physiologic contexts. However, there are no reports on its expression profile and biological roles during lung cancer development. In the current study, both the clinical implications and biological effects of PLAC8 in lung cancer (LC) progression were investigated, and we identified and described the novel Krüppel-like factor 4 (KLF4)/PLAC8 regulatory pathway in cancer progression. Elevated PLAC8 levels were positively correlated with tumor size, histological grade, and tumor node metasis (TNM) stage, and LC patients with high PLAC8 expression suffered poor outcomes. In vitro and in vivo assays further revealed that endogenous PLAC8 promoted cell proliferation and tumor formation. We also found downregulated PLAC8 protein in several LC cell lines following the induction of KLF4, and immunohistochemistry analysis of LC tissues by microarray indicated a potential inverse correlation between PLAC8 and KLF4 expression. Luciferase reporter analysis and chromatin immunoprecipitation assays determined that KLF4 negatively regulated PLAC8 promoter activity via directly binding to the promoter region. Furthermore, the growth inhibition resulting from KLF4 overexpression was partially rescued by ectopic PLAC8 expression. Together, our data uncovered a previously unidentified role of PLAC8 as a central mediator in LC progression. PLAC8 was transcriptionally repressed by KLF4, and the novel KLF4/PLAC8 axis may act as a promising candidate target for LC diagnosis and therapy.
Salvianolic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1α signaling pathway
Authors: Wei Jie , Wu Jun , Xu Wen , Nie Hong , Zhou Ruiqing , Wang Rui , Liu Yang , Tang Guoyao , Wu Jianyong 
Published: May 2018

AbstractOur previous study demonstrated a progressive glycolytic perturbation during the course of DMBA-induced hamster oral carcinogenesis, which was attenuated by salvianolic acid B (Sal-B) treatment along with decreased incidences of oral squamous cell carcinoma (OSCC) formation. It was proposed that metabolic modulation should be an additional mode of action attributable to Sal-B’s anti-carcinogenic activity. However, the molecular mechanisms underlying Sal-B-induced metabolic modulation function remained elusive. In the present study, we performed next-generation sequencing (NGS) profiling in the same animal model and found Sal-B treatment evoked a general downregulation of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) and hypoxia inducible factor 1α subunit (HIF-1α) signaling pathways, which might contribute to Sal-B’s metabolic modulation activity. The inhibitory effects of Sal-B on aerobic glycolysis, as well as PI3K/AKT and HIF-1α signaling pathways, were validated in two well-characterized OSCC cell lines (Cal27 and HN4), and premalignant oral Leuk1 cells and Sal-B treatment led to elevation of the loss of mitochondrial membrane potential (MMP), increased cell apoptosis, and reduced abilities of colony formation. Rescue assays suggested that compared with Sal-B treatment group, Akt or hif-1a overexpression attenuated the inhibitory effect of Sal-B on glucose uptake and intracellular lactate level. Taken together, our results suggested that Sal-B modulated aberrant glucose metabolism via the PI3K/AKT/HIF-1α signaling pathways, which might contribute to the anti-carcinogenic activity of Sal-B.
FoxM1-dependent RAD51 and BRCA2 signaling protects idiopathic pulmonary fibrosis fibroblasts from radiation-induced cell death
Authors: Im Jintaek , Lawrence Jessica , Seelig Davis , Nho Richard S. 
Published: May 2018

AbstractRadiation therapy is critical for the control of many tumors and lung is an important dose-limiting organ that impacts radiation dose prescribed to avoid irreversible pulmonary fibrosis in cancer survivors. Idiopathic pulmonary fibrosis (IPF) is a chronic, irreversible lung disease caused by aberrantly activated lung (myo)fibroblasts. The presence of pro-fibrotic, apoptosis-resistant fibroblasts in IPF promotes progressive fibrosis and may have a role in other diseases, if these resistant cells are selected for as a consequence of treatment. However, the pathological response of IPF fibroblasts to radiation compared to non-IPF lung fibroblasts is not known. To address this, we examined fibroblast viability following radiation in lung fibroblasts from IPF and non-IPF patients and the underlying mechanism that protects IPF fibroblasts from radiation-induced death. IPF fibroblasts are significantly more resistant to apoptosis compared to non-IPF lung fibroblasts, suggesting that resistance to radiation-induced cell death is a predominant mechanism leading to lung fibrosis. Analysis of γH2AX induction demonstrated that radiation-induced DNA damage is reduced in IPF fibroblasts and correlates to the activation of the transcription factor forkhead box M1 (FoxM1) and subsequent upregulation of DNA repair proteins RAD51 and BRCA2. FoxM1 activation occurs secondary to FoxO3a suppression in IPF fibroblasts while restoration of FoxO3a function sensitizes IPF fibroblasts to radiation-induced cell death and downregulates FoxM1, RAD51, and BRCA2. Our findings support that increased FoxO3a/FoxM1-dependent DNA repair may be integral to the preservation of death-resistant fibrotic fibroblasts after radiation and that selective targeting of radioresistant fibroblasts may mitigate fibrosis.
Celastrol alleviates renal fibrosis by upregulating cannabinoid receptor 2 expression
Authors: Tang Ming , Cao Xu , Zhang Kun , Li You , Zheng Quan-you , Li Gui-qing , He Qian-hui , Li Shu-jing , Xu Gui-lian , Zhang Ke-qin 
Published: May 2018

AbstractRenal fibrosis is the final manifestation of various chronic kidney diseases, and no effective therapy is available to prevent or reverse it. Celastrol, a triterpene that derived from traditional Chinese medicine, is a known potent anti-fibrotic agent. However, the underlying mechanisms of action of celastrol on renal fibrosis remain unknown. In this study, we found that celastrol treatment remarkably attenuated unilateral ureteral obstruction (UUO)-induced mouse renal fibrosis. This was evidenced by the significant reduction in tubular injury; collagen deposition; accumulation of fibronectin, collagen I, and α-smooth muscle actin; and the expression levels of pro-fibrotic factors Vim, Cola1, and TGF-β1 mRNA, as well as inflammatory responses. Celastrol showed similar effects in a folic acid-induced mouse renal fibrosis model. Furthermore, celastrol potentiated the expression of the anti-fibrotic factor cannabinoid receptor 2 (CB2R) in established mouse fibrotic kidney tissues and transforming growth factor β1 (TGF-β1)-stimulated human kidney 2 (HK-2) cells. In addition, the CB2R antagonist (SR144528) abolished celastrol-mediated beneficial effects on renal fibrosis. Moreover, UUO- or TGF-β1-induced activation of the pro-fibrotic factor SMAD family member 3 (Smad3) was markedly inhibited by celastrol. Inhibition of Smad3 activation by an inhibitor (SIS3) markedly reduced TGF-β1-induced downregulation of CB2R expression. In conclusion, our study provides the first direct evidence that celastrol significantly alleviated renal fibrosis, by contributing to the upregulation of CB2R expression through inhibiting Smad3 signaling pathway activation. Therefore, celastrol could be a potential drug for treating patients with renal fibrosis.
HMGA1 exacerbates tumor growth through regulating the cell cycle and accelerates migration/invasion via targeting miR-221/222 in cervical cancer
Authors: Fu Fangfang , Wang Tian , Wu Zhangying , Feng Yourong , Wang Wenwen , Zhou Su , Ma Xiangyi , Wang Shixuan 
Published: May 2018

AbstractHigh-mobility group AT-hook1 (HMGA1, formerly HMG-I/Y), an architectural transcription factor, participates in a number of tumor biological processes. However, its effect on cervical cancer remains largely indistinct. In this study, we found that HMGA1 was generally overexpressed in cervical cancer tissues and was positively correlated with lymph node metastasis and advanced clinical stage. Via exogenously increasing or decreasing the expression of HMGA1, we showed that HMGA1 affected the proliferation, colony formation, migration and invasion of cervical cancer cells in vitro. Rescue experiments suggested that miR-221/222 could partly reverse HMGA1-mediated migration and invasion processes. Mechanistically, we discovered that HMGA1 accelerated the G1/S phase transition by regulating the expression of cyclin D1 and cyclin E1, which was consistent with the results of the in vivo experiment. Furthermore, we found that HMGA1 regulated the expression of the miR-221/222 cluster at the transcriptional level and that miR-221/222 targeted the 3′UTR of tissue inhibitor of metalloproteinases 3(TIMP3). We propose a fresh perspective that HMGA1 participates in the migration and invasion process via the miR-221/222-TIMP3-MMP2/MMP9 axis in cervical cancer. In summary, our study identified a critical role played by HMGA1 in the progression of cervical cancer and the potential mechanisms by which exerts its effects, suggesting that targeting HMGA1-related pathways could be conducive to the therapies for cervical cancer.
The Holocene retreat dynamics and stability of Petermann Glacier in northwest Greenland
Authors: Jakobsson Martin , Hogan Kelly A. , Mayer Larry A. , Mix Alan , Jennings Anne , Stoner Joe , Eriksson Björn , Jerram Kevin , Mohammad Rezwan , Pearce Christof , Reilly Brendan , Stranne Christian 
Published: May 2018

AbstractSubmarine glacial landforms in fjords are imprints of the dynamic behaviour of marine-terminating glaciers and are informative about their most recent retreat phase. Here we use detailed multibeam bathymetry to map glacial landforms in Petermann Fjord and Nares Strait, northwestern Greenland. A large grounding-zone wedge (GZW) demonstrates that Petermann Glacier stabilised at the fjord mouth for a considerable time, likely buttressed by an ice shelf. This stability was followed by successive backstepping of the ice margin down the GZW’s retrograde backslope forming small retreat ridges to 680 m current depth (∼730–800 m palaeodepth). Iceberg ploughmarks occurring somewhat deeper show that thick, grounded ice persisted to these water depths before final breakup occurred. The palaeodepth limit of the recessional moraines is consistent with final collapse driven by marine ice cliff instability (MICI) with retreat to the next stable position located underneath the present Petermann ice tongue, where the seafloor is unmapped.
Impairment in delay discounting in schizophrenia and schizoaffective disorder but not primary mood disorders
Authors: Brown Hannah E. , Hart Kamber L. , Snapper Leslie A. , Roffman Joshua L. , Perlis Roy H. 
Published: May 2018

AbstractA measure of planning and impulse control, the delay-discounting (DD) task estimates the extent to which an individual decreases the perceived value of a reward as the reward is delayed. We examined cross-disorder performance between healthy controls (n = 88), individuals with bipolar disorder (n = 23), major depressive disorder (n = 43), and primary psychotic disorders (schizophrenia and schizoaffective disorder; n = 51) on the DD task (using a $10 delayed larger reward), as well as the interaction of DD scores with other symptom domains (cognition, psychosis, and affect). We found that individuals with schizophrenia and schizoaffective disorder display significantly greater rates of discounting compared to healthy controls, while individuals with a primary mood disorder do not differ from healthy controls after adjustment for IQ. Further, impairment in working memory is associated with higher discounting rates among individuals with schizophrenia and schizoaffective disorder, but cognitive dysfunction alone does not account for the extent of impairment in DD. Taken together, these results suggest an impaired ability to plan for the future and make adaptive decisions that are specific to individuals with psychotic disorders, and likely related to adverse functional outcomes. More generally, this work demonstrates the presence of variation in impulsivity across major psychiatric illnesses, supporting the use of a trans-diagnostic perspective.
Gallid herpesvirus 3 SB-1 strain as a recombinant viral vector for poultry vaccination
Authors: Sadigh Yashar , Powers Claire , Spiro Simon , Pedrera Miriam , Broadbent Andrew , Nair Venugopal 
Published: May 2018

AbstractLive herpesvirus-vectored vaccines are widely used in veterinary medicine to protect against many infectious diseases. In poultry, three strains of herpesvirus vaccines are used against Marek’s disease (MD). However, of these, only the herpesvirus of turkeys (HVT) has been successfully developed and used as a recombinant vaccine vector to induce protection against other avian viral diseases such as infectious bursal disease (IBD), Newcastle disease (ND) or avian influenza (AI). Although effective when administered individually, recombinant HVT vectors have limitations when combined in multivalent vaccines. Thus there is a need for developing additional viral vectors that could be combined with HVT in inducing protection against multiple avian diseases in multivalent vaccines.Gallid herpesvirus3 (GaHV3) strain SB-1 is widely used by the poultry industry as bivalent vaccine in combination with HVT to exploit synergistic effects against MD. Here, we report the development and application of SB-1 as a vaccine vector to express the VP2 capsid antigen of IBD virus. A VP2 expression cassette was introduced into the SB-1 genome at three intergenic locations (UL3/UL4, UL10/UL11 and UL21/UL22) using recombineering methods on the full-length pSB-1 infectious clone of the virus. We show that the recombinant SB-1 vectors expressing VP2 induced neutralising antibody responses at levels comparable to that of commercial HVT-based VAXXITEKHVT+IBDvaccine. Birds vaccinated with the experimental recombinant SB-1 vaccine were protected against clinical disease after challenge with the very virulent UK661 IBDV isolate, demonstrating its value as an efficient viral vector for developing multivalent vaccines against avian diseases.
Mitochondrial imaging in live or fixed tissues using a luminescent iridium complex
Authors: Sorvina Alexandra , Bader Christie A. , Darby Jack R. T. , Lock Mitchell C. , Soo Jia Yin , Johnson Ian R. D. , Caporale Chiara , Voelcker Nicolas H. , Stagni Stefano , Massi Massimiliano , Morrison Janna L. , Plush Sally E. , Brooks Douglas A. 
Published: May 2018

AbstractMitochondrial morphology is important for the function of this critical organelle and, accordingly, altered mitochondrial structure is exhibited in many pathologies. Imaging of mitochondria can therefore provide important information about disease presence and progression. However, mitochondrial imaging is currently limited by the availability of agents that have the capacity to image mitochondrial morphology in both live and fixed samples. This can be particularly problematic in clinical studies or large, multi-centre cohort studies, where tissue archiving by fixation is often more practical. We previously reported the synthesis of an iridium coordination complex [Ir(ppy)2(MeTzPyPhCN)]+; where ppy is a cyclometalated 2-phenylpyridine and TzPyPhCN is the 5-(5-(4-cyanophen-1-yl)pyrid-2-yl)tetrazolate ligand; and showed that this complex (herein referred to as IraZolve-Mito) has a high specificity for mitochondria in live cells. Here we demonstrate that IraZolve-Mito can also effectively stain mitochondria in both live and fixed tissue samples. The staining protocol proposed is versatile, providing a universal procedure for cell biologists and pathologists to visualise mitochondria.
The quest for identifiability in human functional connectomes
Authors: Amico Enrico , Goñi Joaquín 
Published: May 2018

AbstractThe evaluation of the individual “fingerprint” of a human functional connectome (FC) is becoming a promising avenue for neuroscientific research, due to its enormous potential inherent to drawing single subject inferences from functional connectivity profiles. Here we show that the individual fingerprint of a human functional connectome can be maximized from a reconstruction procedure based on group-wise decomposition in a finite number of brain connectivity modes. We use data from the Human Connectome Project to demonstrate that the optimal reconstruction of the individual FCs through connectivity eigenmodes maximizes subject identifiability across resting-state and all seven tasks evaluated. The identifiability of the optimally reconstructed individual connectivity profiles increases both at the global and edgewise level, also when the reconstruction is imposed on additional functional data of the subjects. Furthermore, reconstructed FC data provide more robust associations with task-behavioral measurements. Finally, we extend this approach to also map the most task-sensitive functional connections. Results show that is possible to maximize individual fingerprinting in the functional connectivity domain regardless of the task, a crucial next step in the area of brain connectivity towards individualized connectomics.