bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of various healthy dietary patterns with biological age acceleration and the mediating role of gut microbiota: results from the China Multi-Ethnic Cohort study
Authors: Zhang Hongmei , Zuo Haojiang , Xiang Yi , Cai Jiajie , Zhang Ning , Yang Fen , Huang Shourui , Zhang Yuan , Chen Hongxiang , Li Sicheng , Yang Tingting , Mi Fei , Chen Liling , Han Mingming , Li Jingzhong , Xiao Xiong , Zhao Xing 
Published: November 2024

AbstractTo investigate the associations between dietary patterns and biological ageing, identify the most recommended dietary pattern for ageing and explore the potential mediating role of gut microbiota in less-developed ethnic minority regions (LEMRs). This prospective cohort study included 8288 participants aged 30–79 years from the China Multi-Ethnic Cohort study. Anthropometric measurements and clinical biomarkers were utilised to construct biological age based on Klemera and Doubal’s method (KDM-BA) and KDM-BA acceleration (KDM-AA). Dietary information was obtained through the baseline FFQ. Six dietary patterns were constructed: plant-based diet index, healthful plant-based diet index, unhealthful plant-based diet index, healthy diet score, Dietary Approaches to Stop Hypertension (DASH), and alternative Mediterranean diets. Follow-up adjusted for baseline analysis assessed the associations between dietary patterns and KDM-AA. Additionally, quantile G-computation identified significant beneficial and harmful food groups. In the subsample of 764 participants, we used causal mediation model to explore the mediating role of gut microbiota in these associations. The results showed that all dietary patterns were associated with KDM-AA, with DASH exhibiting the strongest negative association (β = −0·91, 95 % CI (–1·19, −0·63)). The component analyses revealed that beneficial food groups primarily included tea and soy products, whereas harmful groups mainly comprised salt and processed vegetables. In mediation analysis, the Synergistetes and Pyramidobacter possibly mediated the negative associations between plant-based diets and KDM-AA (5·61–9·19 %). Overall, healthy dietary patterns, especially DASH, are negatively associated with biological ageing in LEMRs, indicating that Synergistetes and Pyramidobacter may be potential mediators. Developing appropriate strategies may promote healthy ageing in LEMRs.
Information and Idioms in Circulation: Engaging the Minority Classification in 1930s India
Authors: Aspengren Henrik Chetan 
Published: November 2024

AbstractSeveral studies have shown how a system of social classifications influenced the bureaucracy of British India when dealing with Indian society on a day-to-day basis. We know less, however, about how representatives of Indian society engaged such classifications and the information accompanying it to advance their own political agendas. This article examines how the classification of “minorities,” along with data connected to it, impacted discourse of Indian political actors in the early 1930s. The article presents a novel method to analyse first-person speech for themes and information content. It then applies the method to interventions by Indian delegates to the Sub-committee on Minorities of the India Round Table Conference, held in London, 1930–2. The article places the empirical investigation within a conceptual frame inspired by Ian Hacking's “looping effect.” Hacking attempts to capture how those classified negotiate imposed designations to advance agendas beneficial to themselves. The following study shows how Indian delegates engaged minority classification in a variety of ways in their political argumentation. The study also shows how information related to the minority classification was “looped” in speech by Indian actors to advance political claims and consolidate identities.
Exploring the linkage between health technology assessment and decision making during COVID-19 public health emergency in a developing country: analysis of processes and results
Authors: Hasdeu Santiago , Beliera Anabel , Alvarez Jorgelina , Sánchez Viamonte Julián 
Published: November 2024

Abstract

Objectives
The decision-making (DM) process in public administration is the subject of research from different perspectives and disciplines. Evidence-based policies, such as health technology assessment (HTA), are not the only support on which public policies are designed. During the COVID-19 pandemic WHO, national and subnational institutions developed HTA reports to guide DM. Despite this, inadequate variability was observed in the health technologies recommended and reimbursed by different provincial Health Ministries in a federally organized developing country like Argentina. The processes and results of DM on health technologies for COVID-19 in Health Ministries of Argentina were inquired.

Methods
A retrospective research design was developed, with triangulation of quantitative and qualitative methods. We retrieved information for the years 2020–2021 through document review of official webpages, surveys, and interviews with decision-makers of the 25 Argentinian Ministries of Health. We analyzed the recommendations and reimbursement policies of seven health technologies.

Results
In contradiction with WHO’s policies, ivermectine, inhaled ibuprofen, convalescent plasma and equine serum were widely recommended by most of Argentina’s health ministries outside a clinical trial context, with risks for patients and a huge opportunity cost.

Conclusions
Despite an important HTA institutional capacity, the impact of HTA organizations and their technical reports was limited. Health Ministries with institutionalized HTA units had more adherence to WHO recommendations, but the influence of different technical and political criteria was identified. Power relations within and outside the administration, the pharmaceutical industry and academics, the media, social pressure, the judicial and legislative powers, and the political context strongly influenced DM.
Health technology assessment of medicinal products in Greece: a 5-year (2018–2023) review of timelines and productivity
Authors: Chantzaras Athanasios , Margetis Athanasios , Kani Chara , Koutsiouris Vassilis , Bacopoulou Flora 
Published: November 2024

Abstract

Objectives
To assess the health technology assessment (HTA) process in Greece from its establishment in 2018 until 2023 in terms of timeliness and productivity.

Methods
Data were collected from the HTA Committee’s database and other publicly available sources. The overall study timeframe was divided into three periods: (i) July 2018–January 2020, (ii) January 2020–July 2021, and (iii) July 2021–February 2023.

Results
During the study period, a total of 1,157 applications for medicinal products (MPs) (including 219 new active substances (NAS) and orphans) were submitted to the HTA Committee. The number of HTA recommendations increased from 60 (first period) to 641 (third period), while the backlog of MPs pending HTA and price negotiations decreased from 89 and 106 (January 2020) to 8 and 44 (February 2023), respectively. The median time intervals for all application types decreased significantly over time. In February 2023, the median time for clinical data assessment of NAS (excluding orphans) almost halved from 207 days in the first period to 114 days; median times for NAS and orphans from regulatory approval to HTA application were 420 and 457 days, and from HTA application to reimbursement 228 and 417 days, respectively.

Conclusions
The performance of the HTA process in Greece improved significantly over time, with increased MP appraisals, backlog reduction, and decreased timelines. Delays in reimbursement of NAS were mainly caused by the long gap between regulatory approval and HTA application. Overall, HTA review times in Greece are now on par with that of well-established European HTA systems.
Banking on distant shores: a comparison of the development of foreign banks in pre-World War I China and Japan
Authors: Moazzin Ghassan 
Published: November 2024

Abstract
This article provides the first in-depth systematic comparison of foreign banking in pre-World War I China and Japan. As the article shows, after their entry into China and Japan, the presence and activities of foreign banks in China and Japan differed markedly, with these banks developing a much more prominent position in China. Making use of sources in German, English, Chinese, and Japanese, this article aims to explain why foreign banks in China and Japan developed so differently before World War I. It does so by first providing an overview of the development of foreign banks in both countries and then discussing their activities and development with regards to Chinese and Japanese financial institutions, trade finance, and public finance. The article shows that it was Japan's emphasis on financial reforms that led to the limited presence of foreign banks in that country.
Experiences of acceptance and commitment therapy for people living with motor neuron disease (MND): a qualitative study from the perspective of people living with MND and therapists
Authors: Rawlinson Charlotte , Gould Rebecca L. , McDermott Christopher J. , Thompson Ben , Weeks Kirsty , Gossage-Worrall Rebecca , Serfaty Marc A. , Graham Christopher D. , McCracken Lance , White David , Howard Robert J. , Al-Chalabi Ammar , Goldstein Laura H. , Orrell Richard W. , Chhetri Suresh K. , Noad Rupert , Radunovic Aleksandar , Williams Tim , Young Carolyn A. , Bursnall Matt , Bradburn Mike , Young Tracey , Ealing John , McLeod Hamish , Weatherly Helen , Cave Richard , Pagnini Francesco , Cooper Cindy , Shaw Pamela J. , Lawrence Vanessa ,   the COMMEND Collaboration Group
Published: November 2024

Abstract

Background:
Motor neuron disease (MND) is a progressive, fatal, neurodegenerative condition that affects motor neurons in the brain and spinal cord, resulting in loss of the ability to move, speak, swallow and breathe. Acceptance and commitment therapy (ACT) is an acceptance-based behavioural therapy that may be particularly beneficial for people living with MND (plwMND). This qualitative study aimed to explore plwMND’s experiences of receiving adapted ACT, tailored to their specific needs, and therapists’ experiences of delivering it.

Method:
Semi-structured qualitative interviews were conducted with plwMND who had received up to eight 1:1 sessions of adapted ACT and therapists who had delivered it within an uncontrolled feasibility study. Interviews explored experiences of ACT and how it could be optimised for plwMND. Interviews were audio recorded, transcribed and analysed using framework analysis.

Results:
Participants were 14 plwMND and 11 therapists. Data were coded into four over-arching themes: (i) an appropriate tool to navigate the disease course; (ii) the value of therapy outweighing the challenges; (iii) relevance to the individual; and (iv) involving others. These themes highlighted that ACT was perceived to be acceptable by plwMND and therapists, and many participants reported or anticipated beneficial outcomes in the future, despite some therapeutic challenges. They also highlighted how individual factors can influence experiences of ACT, and the potential benefit of involving others in therapy.

Conclusions:
Qualitative data supported the acceptability of ACT for plwMND. Future research and clinical practice should address expectations and personal relevance of ACT to optimise its delivery to plwMND.

Key learning aims

(1)
To understand the views of people living with motor neuron disease (plwMND) and therapists on acceptance and commitment therapy (ACT) for people living with this condition.

(2)
To understand the facilitators of and barriers to ACT for plwMND.

(3)
To learn whether ACT that has been tailored to meet the specific needs of plwMND needs to be further adapted to potentially increase its acceptability to this population.
Multifunctional and tunable bandpass filters with RF codesigned isolator and impedance matching capabilities
Authors: Li Kexin , Psychogiou Dimitra 
Published: November 2024

Abstract
This paper presents the radio frequency (RF) design and experimental validation of a multifunctional bandpass filtering (BPF) concept with center frequency tunability and RF codesigned isolator and impedance matching functionality. The multifunctional bandpass filter/isolator (BPFI) concept combines frequency-tunable reciprocal resonators and nonreciprocal frequency-selective stages (NFSs) to realize center frequency tunability and fully directional transfer characteristics. The NFS, as the core component of the BPFI concept, exhibits frequency-selective transmission response in the forward direction and signal cancellation in the reverse direction. Its tunability is achieved by combining a transistor-based network with a tunable capacitively loaded coupled-line section. Furthermore, the NFS facilitates matching of different source loads allowing for the BPFIs to be used as reconfigurable matching networks. For experimental validation, an NFS and two BPFIs were designed, manufactured, and measured at L band. Their features include (i) NFS: center frequency tuning from 1.55 to 1.9 GHz with maximum directivity from 20 to 52 dB and gain from 0.3 to 1.3 dB. (ii) BPFI (topology A): center frequency tuning from 1.52 to 1.9 GHz with maximum directivity from 20 to 44 dB and gain from −1.5 to −0.5 dB. (iii) BPFI (topology C): ability to match complex loads with 26 + j18 Ω and 26 − j14 Ω.
Deciphering Paleocene‐Eocene Thermal Maximum Climatic Dynamics: Insights From Oxygen and Hydrogen Isotopes in Clay Minerals of Paleosols From the Southern Pyrenees
Authors: Jaimes‐Gutierrez Rocio , Adatte Thierry , Pucéat Emmanuelle , Vennemann Torsten , Prieur Marine , Wild Amanda L. , Khozyem Hassan , Vaucher Romain , Castelltort Sebastien 
Published: November 2024

AbstractThis study focuses on the Paleocene‐Eocene Thermal Maximum (PETM), a hyperthermal event characterized by a rapid increase in global temperature (5–8°C) over 20 ka, in the Southern Pyrenean Foreland Basin. Although there is evidence of increased flood discharge and erosion in the Southern Pyrenees, how paleoclimatic conditions and weathering evolved remains to be assessed. This study focuses on the catchment scale climatological changes recorded in the clay minerals of floodplain paleosols, giving insights into how rainfall affected the weathering regime during and after the hyperthermal event. The oxygen (δ18O) and hydrogen (δD) isotope compositions were analyzed in two clay fractions in paleosols of the Esplugafreda continental section. The clay minerals comprise a dominant smectite‐rich assemblage, which indicates a predominantly seasonal, semi‐arid climate throughout the section. Two positive excursions in the δ18O record during the Pre‐Onset Excursion (POE) and the Syn‐PETM support an increase in air near‐surface temperature. Using the δD and δ18O smectite fractionation factors, we estimate a Mean Annual Air Temperature (MAAT) of 24.2 ± 1.0°C for the POE and 27.0 ± 0.8°C for the Syn‐PETM. The δD values show a relatively stable composition during the climatic disturbance, which suggests that this mid‐latitude catchment was overall characterized by low yearly rainfall, with a peak in extreme events during the body of the PETM and a trend toward aridification during the recovery phase of the PETM, supported by the paleosol morphotype. These climatic conditions suggest a kinetically controlled weathering regime, where physical transport of the sediments played a primary role as a denudation mechanism.
Proliferation associated 2G4 is required for the ciliation of vertebrate motile cilia
Authors: Lee Moonsup , Carpenter Christina , Hwang Yoo-Seok , Yoon Jaeho , Lu Quanlong , Westlake Christopher J. , Moody Sally A. , Yamaguchi Terry P. , Daar Ira O. 
Published: November 2024

AbstractMotile cilia are critical structures that regulate early embryonic development and tissue homeostasis through synchronized ciliary motility. The formation of motile cilia is dependent on precisely controlled sequential processes including the generation, migration, and docking of centrioles/basal bodies as well as ciliary growth. Using the published proteomics data from various organisms, we identified proliferation-associated 2G4 as a novel regulator of ciliogenesis. Loss-of-function studies using Xenopus laevis as a model system reveal that Pa2G4 is essential for proper ciliogenesis and synchronized movement of cilia in multiciliated cells (MCCs) and the gastrocoel roof plate (GRP). Pa2G4 morphant MCCs exhibit defective basal body docking to the surface as a result of compromised Rac1 activity, apical actin network formation, and immature distal appendage generation. Interestingly, the regions that include the RNA-binding domain and the C-terminus of Pa2G4 are necessary for ciliogenesis in both MCCs and GRP cells. Our findings may provide insights into motile cilia-related genetic diseases such as Primary Ciliary Dyskinesia.
PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation
Authors: Chin Sang Christopher , Moore Gaelen , Tereshchenko Maria , Zhang Hongshan , Nosella Michael L , Dasovich Morgan , Alderson T Reid , Leung Anthony K L , Finkelstein Ilya J , Forman-Kay Julie D , Lee Hyun O 
Published: November 2024

AbstractPoly(ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA damage and plays crucial roles in recruiting DNA repair proteins through its activity – poly(ADP-ribosyl)ation (PARylation). The enrichment of DNA repair proteins at sites of DNA damage has been described as the formation of a biomolecular condensate. However, it remains unclear how exactly PARP1 and PARylation contribute to the formation and organization of DNA repair condensates. Using recombinant human single-strand repair proteins in vitro, we find that PARP1 readily forms viscous biomolecular condensates in a DNA-dependent manner and that this depends on its three zinc finger (ZnF) domains. PARylation enhances PARP1 condensation in a PAR chain length-dependent manner and increases the internal dynamics of PARP1 condensates. DNA and single-strand break repair proteins XRCC1, LigIII, Polβ, and FUS partition in PARP1 condensates, although in different patterns. While Polβ and FUS are both homogeneously mixed within PARP1 condensates, FUS enrichment is greatly enhanced upon PARylation whereas Polβ partitioning is not. XRCC1 and LigIII display an inhomogeneous organization within PARP1 condensates; their enrichment in these multiphase condensates is enhanced by PARylation. Functionally, PARP1 condensates concentrate short DNA fragments, which correlates with PARP1 clusters compacting long DNA and bridging DNA ends. Furthermore, the presence of PARP1 condensates significantly promotes DNA ligation upon PARylation. These findings provide insight into how PARP1 condensation and PARylation regulate the assembly and biochemical activities of DNA repair factors, which may inform on how PARPs function in DNA repair foci and other PAR-driven condensates in cells.
Severe fever with thrombocytopenia syndrome virus induces lactylation of m6A reader protein YTHDF1 to facilitate viral replication
Authors: Liu Bingxin , Tian Xiaoyan , Li Linrun , Zhang Rui , Wu Jing , Jiang Na , Yuan Meng , Chen Deyan , Su Airong , Xu Shijie , Wu Zhiwei 
Published: November 2024

AbstractSevere fever with thrombocytopenia syndrome virus (SFTSV), an emerging infectious pathogen with a high fatality rate, is an enveloped tripartite segmented single-stranded negative-sense RNA virus. SFTSV infection is characterized by suppressed host innate immunity, proinflammatory cytokine storm, failure of B-cell immunity, and robust viral replication. m6A modification has been shown to play a role in viral infections. However, interactions between m6A modification and SFTSV infection remain poorly understood. Through MeRIP-seq, we identify m6A modifications on SFTSV RNA. We show that YTHDF1 can bind to m6A modification sites on SFTSV, decreasing the stability of SFTSV RNA and reducing the translation efficiency of SFTSV proteins. The SFTSV virulence factor NSs increases lactylation of YTHDF1 and YTHDF1 degradation, thus facilitating SFTSV replication. Our findings indicate that the SFTSV protein NSs induce lactylation to inhibit YTHDF1 as a countermeasure to host’s YTHDF1-mediated degradation of m6A-marked viral mRNAs.
The Stability of Linguistic Skills of Arabic-Speaking Children Between Kindergarten and First Grade
Authors: Mansour-Adwan Jasmeen , Khateb Asaid 
Published: November 2024

Purpose:
This study aimed to evaluate the stability of phonological awareness (PA) and language achievements between kindergarten and first grade among Arabic-speaking children.

Method:
A total of 1,158 children were assessed in PA and language skills in both grades and were classified based on distinct and integrated achievements on PA and language following percentiles' cutoff criteria. The classification of distinct achievements constituted high, intermediate, low, and very low achievement-based groups for each domain. The classification of the integrated achievements on both domains constituted four groups: intermediate-high PA and language, very low PA, very low language, and doubly low (very low PA and language). Descriptive statistics and McNemar's tests were used to examine the stability of these groups.

Results:
The analyses showed a significant improvement in achievements on most tasks. The distinct classification for PA and language indicated that many more kindergarteners in the extreme distribution with high and very low achievement levels maintained this profile in first grade compared to those with intermediate achievements. For PA, 55.7% of kindergarteners with high, 30% with intermediate, 30.4% with low, and 45.5% with very low achievements maintained their achievements in first grade. For language, 52.5% of kindergarteners with high, 34.5% with intermediate, 38.8% with low, and 59.8% with very low achievements maintained their language achievements. The integrated classification indicated a higher achievement stability rate for kindergarteners with intermediate-high PA and language (91.3%) and for doubly low achievers (84.7%) compared to very low PA (24.1%) or very low language (31.8%) achievers.

Conclusions:
The study indicated a higher variability in the distribution of the intermediate achievements compared to the high and very low achievements, which were more stable across grade. The results emphasize the need for dynamic linguistic assessments and early intervention for children with very low achievements in PA and language who show a poor prognosis.