bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Hetero‐Epitaxially Grown Zeolite Membrane
Authors: Jeong Yanghwan , Hong Sungwon , Jang Eunhee , Kim Eunjoo , Baik Hionsuck , Choi Nakwon , Yip Alex C. K. , Choi Jungkyu 
Published: October 2019

AbstractThe secondary growth methodology to form zeolite membranes has stringent requirements for homogeneous epitaxial intergrowth of the seed layer and limits the number of accessible high‐quality zeolite membranes. Despite previous reports on hetero‐epitaxial growth, high‐performance zeolite membranes have yet to be reported using this approach. Here, the successful hetero‐epitaxial growth of highly siliceous ZSM‐58 (DDR‐type zeolite) films from a SSZ‐13 (CHA‐type zeolite) seed layer is reported. The resulting membranes show excellent CO2 perm‐selectivities, having maximum CO2 /N2 and CO2 /CH4 separation factors (SFs) as high as about 17 and 279, respectively, at 30 °C. Furthermore, the hybrid membrane maintains the CO2 perm‐selectivity in the presence of water vapor (the third main component in both cases), that is, CO2 /N2 SF of about 14 and CO2 /CH4 SF of about 78, respectively, at 50 °C (a representative temperature of both CO2‐containing streams).
Catalytic Enantioselective Methylene C(sp3)−H Amidation of 8‐Alkylquinolines Using a Cp*RhIII/Chiral Carboxylic Acid System
Authors: Fukagawa Seiya , Kojima Masahiro , Yoshino Tatsuhiko , Matsunaga Shigeki 
Published: October 2019

AbstractCatalytic enantioselective directed methylene C(sp3)−H amidation reactions of 8‐alkylquinolines using a Cp*RhIII/chiral carboxylic acid (CCA) hybrid catalytic system are described. A binaphthyl‐based chiral carboxylic acid efficiently differentiates between the enantiotopic methylene C−H bonds, which leads to the formation of C−N bonds with good enantioselectivity.
Direct Mechanocatalysis: Palladium as Milling Media and Catalyst in the Mechanochemical Suzuki Polymerization
Authors: Vogt Christian G. , Grätz Sven , Lukin Stipe , Halasz Ivan , Etter Martin , Evans Jack D. , Borchardt Lars 
Published: October 2019

AbstractThe milling ball is the catalyst. We introduce a palladium‐catalyzed reaction inside a ball mill, which makes catalyst powders, ligands, and solvents obsolete. We present a facile and highly sustainable synthesis concept for palladium‐catalyzed C−C coupling reactions, exemplarily showcased for the Suzuki polymerization of 4‐bromo or 4‐iodophenylboronic acid giving poly(para‐phenylene). Surprisingly, we observe one of the highest degrees of polymerization (199) reported so far.
A Low‐Cost and Environmentally Friendly Mixed Polyanionic Cathode for Sodium‐Ion Storage
Authors: Song Tianyi , Yao Wenjiao , Kiadkhunthod Pinit , Zheng Yongping , Wu Nanzhong , Zhou Xiaolong , Tunmee Sarayut , Sattayaporn Suchinda , Tang Yongbing 
Published: October 2019

AbstractSodium‐ion batteries (NIBs) are the most promising alternatives to lithium‐ion batteries in the development of renewable energy sources. The advancement of NIBs depends on the exploration of new electrode materials and fundamental understanding of working mechanisms. Herein, via experimental and simulation methods, we develop a mixed polyanionic compound, Na2Fe(C2O4)SO4⋅H2O, as a cathode for NIBs. Thanks to its rigid three dimensional framework and the combined inductive effects from oxalate and sulfate, it delivered reversible Na insertion/desertion at average discharging voltages of 3.5 and 3.1 V for 500 cycles with Coulombic efficiencies of ca. 99 %. In situ synchrotron X‐ray measurements and DFT calculations demonstrate the Fe2+/Fe3+ redox reactions contribute to electron compensation during Na+ desertion/insertion. The study suggests mixed polyanionic frameworks may provide promising materials for Na ion storage with the merits of low cost and environmental friendliness.
Improved flashover performance and tracking resistance of silicone rubber by direct fluorination
Authors: An Zhenlian , Shen Ruochen , Gao Wenjian , Gu Xiaoxiao , Chen Weijun , Yang Long , Yang Wei , Zhang Zhuo 
Published: October 2019

ABSTRACTSilicone rubber (SIR) samples are fluorinated using a F2/N2 mixture at different temperatures. Physicochemical characteristics are analyzed by attenuated total reflection infrared spectroscopy, X‐ray photoelectron spectroscopy, and scanning electron microscopy. Basic properties of the fluorinated surface layers are investigated, and the intrinsic alternating current (AC) flashover performance and tracking resistance of the surface fluorinated samples are evaluated. The flashover test results indicate that the fluorination leads to an improvement in AC flashover performance of the SIR material, as a result of the competition between the favorable effect of the increase in surface conduction and the adverse effect of a likely increase in surface layer permittivity. The increase in AC flashover voltage is associated with the voltage‐increasing mode of the flashover test. The flashover test results also show an improved tracking resistance of the SIR material by the fluorination, and the improvement is especially significant for the fluorinated surface layer that has less cleavage of SiC bonds or a good compactness as well as a large thickness. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48556.
The assembly of integrated rat intestinal‐hepatocyte cultures
Authors: Kothari Anjaney , Rajagopalan Padmavathy 
Published: October 2019

AbstractThe jejunum is the segment of the small intestine responsible for several metabolism and biotransformation functions. In this report, we have cultured rat jejunum explants in vitro and integrated them with hepatocyte cultures. We have also investigated the changes in jejunum function at different locations since spatial variations in intestinal functions have been reported previously. We divided the length of the rat jejunum into three distinct regions of approximately 9 cm each. We defined the regions as proximal (adjacent to the duodenum), medial, and distal (adjacent to the ileum). Spatiotemporal variations in functions were observed between these regions within the jejunum. Alkaline phosphatase activity (a marker of enterocyte function), decreased twofold between the proximal and distal regions at 4 hr. Lysozyme activity (a marker of Paneth cell function) increased from the proximal to the distal jejunum by 40% at 24 hr. Mucin‐covered areas, a marker of goblet cell function, increased by twofold between the proximal and distal segments of the jejunum at 24 hr. When hepatocytes were integrated with proximal jejunum explants, statistically higher urea (~2.4‐fold) and mucin (57%) production were observed in the jejunum explants. The integrated intestine‐liver cultures can be used as a platform for future investigations.
A Click‐Chemistry‐Based Enrichable Crosslinker for Structural and Protein Interaction Analysis by Mass Spectrometry
Authors: Stadlmeier Michael , Runtsch Leander Simon , Streshnev Filipp , Wühr Martin , Carell Thomas 
Published: October 2019

AbstractMass spectrometry is the method of choice for the characterisation of proteomes. Most proteins operate in protein complexes, in which their close association modulates their function. However, with standard MS analysis, information on protein–protein interactions is lost and no structural information is retained. To gain structural and interactome data, new crosslinking reagents are needed that freeze inter‐ and intramolecular interactions. Herein, the development of a new reagent, which has several features that enable highly sensitive crosslinking MS, is reported. The reagent enables enrichment of crosslinked peptides from the majority of background peptides to facilitate efficient detection of low‐abundant crosslinked peptides. Due to the special cleavable properties, the reagent can be used for MS2 and potentially for MS3 experiments. Thus, the new crosslinking reagent, in combination with high‐end MS, should enable sensitive analysis of interactomes, which will help researchers to obtain important insights into cellular states in health and diseases.
High‐Performance Flexible Asymmetric Supercapacitors Facilitated by N‐doped Porous Vertical Graphene Nanomesh Arrays
Authors: Chi Kai , Zhang Xiangyu , Tian Xin , Zhang Zheye , Wu Zhu , Xiao Fei , Wang Shuai 
Published: October 2019

AbstractThe design of self‐supporting electrode scaffold with large surface area, good flexibility, and high electrical conductivity is of great significance to the development of high performance flexible supercapacitors. Herein, we report the fabrication of N‐doped porous vertical graphene nanomesh arrays (NVGMs) on flexible carbon cloth (CC) substrate (CC@NVGMs) via a facile self‐sacrificing template method. The NVGMs provide large surface area, more growth sites of active materials, good electrical conductivity and short diffusion paths, leading to greatly enhanced performance. After decorating MnO2 nanosheets and polypyrrole films on the NVGMs, the hierarchical nanohybrid electrodes show notable improvement of areal capacitances, greatly decrease of equivalent series resistance, significantly enhancement of rate performance, compare to those of the active materials on bare CC. Furthermore, the flexible asymmetric supercapacitor is assembled by these two nanohybrid electrodes has an energy density of up to 1.92 mWh cm−3.
Electronic Metal‐Support Interaction‐Modified Structures and Catalytic Activity of CeOx Overlayers in CeOx/Ag Inverse Catalysts
Authors: Ren Muqing , Qian Kun , Huang Weixin 
Published: October 2019

AbstractElectronic metal‐support interactions (EMSIs) of oxide‐supported metal catalysts strongly modifies the electronic structures of the supported metal nanoparticles. The strong influence of EMSIs on the electronic structures of oxide overlayers on metal nanoparticles employing cerium oxides/Ag inverse catalysts is reported herein. Ce2O3 overlayers were observed to exclusively form on Ag nanocrystals at low cerium loadings and be resistant to oxidation treatments up to 250 °C, whereas CeO2 overlayers gradually developed as the cerium loading increased. Ag cubes enclosed by {001} facets with a smaller work function exert a stronger EMSI effect on the CeOx overlayers than Ag cubes enclosed by {111} facets. Only the CeO2 overlayers with a fully developed bulk CeO2 electronic structure significantly promote the catalytic activity of Ag nanocrystals in CO oxidation, whereas cerium oxide overlayers with other electronic structures do not. These results successfully extend the concept of EMSIs from oxide‐supported metal catalysts to metal‐supported oxide catalysts.
Alpha‐Carbonic Acid Revisited: Carbonic Acid Monomethyl Ester as a Solid and its Conformational Isomerism in the Gas Phase
Authors: Köck Eva‐Maria , Bernard Jürgen , Podewitz Maren , Dinu Dennis F. , Huber Roland G. , Liedl Klaus R. , Grothe Hinrich , Bertel Erminald , Schlögl Robert , Loerting Thomas 
Published: October 2019

AbstractIn this work, earlier studies reporting α‐H2CO3 are revised. The cryo‐technique pioneered by Hage, Hallbrucker, and Mayer (HHM) is adapted to supposedly prepare carbonic acid from KHCO3. In methanolic solution, methylation of the salt is found, which upon acidification transforms to the monomethyl ester of carbonic acid (CAME, HO‐CO‐OCH3). Infrared spectroscopy data both of the solid at 210 K and of the evaporated molecules trapped and isolated in argon matrix at 10 K are presented. The interpretation of the observed bands on the basis of carbonic acid [as suggested originally by HHM in their publications from 1993–1997 and taken over by Winkel et al., J. Am. Chem. Soc. 2007 and Bernard et al., Angew. Chem. Int. Ed. 2011] is inferior compared with the interpretation on the basis of CAME. The assignment relies on isotope substitution experiments, including deuteration of the OH‐ and CH3‐ groups as well as 12C and 13C isotope exchange and on variation of the solvents in both preparation steps. The interpretation of the single molecule spectroscopy experiments is aided by a comprehensive calculation of high‐level ab initio frequencies for gas‐phase molecules and clusters in the harmonic approximation. This analysis provides evidence for the existence of not only single CAME molecules but also CAME dimers and water complexes in the argon matrix. Furthermore, different conformational CAME isomers are identified, where conformational isomerism is triggered in experiments through UV irradiation. In contrast to earlier studies, this analysis allows explanation of almost every single band of the complex spectra in the range between 4000 and 600 cm−1.
Hexabenzocoronene Graphitic Nanocoils Appended with Crown Ethers: Supramolecular Chirality Induced by Host–Guest Interaction
Authors: Zeng Wang , Zhang Wei , Li Xianying , Jin Wusong , Zhang Dengqing 
Published: October 2019

AbstractWe have designed and synthesized two new achiral hexa‐peri‐hexabenzocoronene (HBC) derivatives, HBCCE and HBCTEG‐CE, which bear the crown ether as the pendant for the amino acid binding site. The HBCCE self‐assembled into a racemic mixture of P‐ and M‐handed helical nanocoils, however, in the presence of chiral amino acid guests, it formed helical nanocoils with one‐handed screw sense. The effects of the concentration, type and configuration of the guests on the induced circular dichroism (ICD) during the co‐assembly of HBCCE with chiral amino acids were also investigated. Additionally, after complete removal of the chiral guests, the optically active nanocoils did not racemize, even in the presence of excess amino acids with the opposite configuration. In contrast, HBCTEG‐CE with a long triethylene glycol (TEG) chain between the crown ether group and the HBC unit did not exhibit ICD during the co‐assembly with chiral amino acids.
Outcomes of multimodal therapy in a large series of patients with anaplastic thyroid cancer
Authors: Fan Dan , Ma Jennifer , Bell Andrew C. , Groen Andries H. , Olsen Kyrie S. , Lok Benjamin H. , Leeman Jonathan E. , Anderson Erik , Riaz Nadeem , McBride Sean , Ganly Ian , Shaha Ashok R. , Sherman Eric J. , Tsai C. Jillian , Kang Jung J. , Lee Nancy Y. 
Published: October 2019

BackgroundThe role of radiotherapy (RT) in the treatment of patients with anaplastic thyroid cancer (ATC) for local tumor control is critical because mortality often is secondary to complications of tumor volume rather than metastatic disease. Herein, the authors report the long‐term outcomes of RT for patients with ATC.MethodsA total of 104 patients with histologically confirmed ATC were identified who presented to the study institution between 1984 and 2017 and who received curative‐intent or postoperative RT. Locoregional progression‐free survival (LPFS), overall survival (OS), and distant metastasis–free survival were assessed.ResultsThe median age of the patients was 63.5 years. The median follow‐up was 5.9 months (interquartile range, 2.7‐17.0 months) for the entire cohort and 10.6 months (interquartile range, 5.3‐40.0 months) for surviving patients. Thirty‐one patients (29.8%) had metastatic disease prior to the initiation of RT. Concurrent chemoradiation was administered in 99 patients (95.2%) and 53 patients (51.0%) received trimodal therapy. Systemic therapy included doxorubicin (73.7%), paclitaxel with or without pazopanib (24.3%), and other systemic agents (2.0%). The 1‐year OS and LPFS rates were 34.4% and 74.4%, respectively. On multivariate analysis, RT ≥60 Gy was associated with improved LPFS (hazard ratio [HR], 0.135; P = .001) and improved OS (HR, 0.487; P = .004), and trimodal therapy was associated with improved LPFS (HR, 0.060; P = .017). The most commonly observed acute grade 3 adverse events included dermatitis (20%) and mucositis (13%), with no grade 4 subacute or late adverse events noted (adverse events were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events [version 4.0]).ConclusionsRT appears to demonstrate a dose‐dependent, persistent LPFS and OS benefit in patients with locally advanced ATC with an acceptable toxicity profile. Aggressive RT should be strongly considered for the treatment of patients with ATC as part of a trimodal treatment approach.
Electrochemically Facile Hydrogen Evolution Using Ruthenium Encapsulated Two Dimensional Covalent Organic Framework (2D COF)
Authors: Maiti Sayan , Chowdhury Additi Roy , Das Apurba K. 
Published: October 2019

AbstractTwo dimensional covalent organic frameworks (2D COFs) are unique class of crystalline porous polymers which are formed by the covalent bonding between the organic building blocks. Their layers are stacked to each other by non‐covalent interactions. The stacking sequence between the layers is highly significant towards various applications. In this article, we have prepared ruthenium ions encapsulated 2D COF (Ru@COF) from a synthesized COF. We have performed an electrochemical hydrogen evolution reaction using Ru@COF as electrocatalyst. Moreover, Ru@COF shows better electrochemical hydrogen evolution reaction (HER) activity compared to bare RuCl3 and COF. The HER activities are measured in 1.5 M H2SO4 medium. Ru@COF shows onset potential 159 mV with the Tafel slope of 79 mV dec−1. The linear Tafel plot with the slope 79 mV dec−1 indicates Volmer‐Heyrovsky‐Tafel mechanism for the Ru@COF catalysed HER. COF plays a crucial role in maintaining stability and catalytic efficiency of the material. Interestingly, Ru@COF acts as exemplary electrocatalyst material that is used as solid binder‐free cathodic electrode on glassy carbon electrode surface.
Exposure–Response Analyses for Upadacitinib Efficacy and Safety in the Crohn's Disease CELEST Study and Bridging to the Extended‐Release Formulation
Authors: Mohamed Mohamed‐Eslam F. , Klünder Ben , Lacerda Ana P. , Othman Ahmed A. 
Published: October 2019

Upadacitinib plasma concentrations, efficacy, and safety data from 216 subjects with moderate‐to‐severe active Crohn's disease (CD) from the 16‐week induction period of the CELEST study were analyzed to characterize upadacitinib exposure–response relationships in CD. Subjects in CELEST received either placebo or upadacitinib (3, 6, 12, 24 mg b.i.d. or 24 mg q.d.). Exposure–response models were developed and utilized to simulate efficacy of induction doses of the immediate‐release (IR) and extended‐release (ER) formulations. Upadacitinib exposures associated with 18–24 mg b.i.d. (IR formulation) or 45–60 mg q.d. (ER formulation) are estimated to have greater efficacy during 12‐week induction in patients with CD compared with lower doses. No exposure–response relations were observed with decreases in hemoglobin or lymphocytes at week 16 or with herpes zoster infections, pneumonia, or serious infections during 16 weeks of treatment in this study. These analyses informed the selection of upadacitinib induction dose for phase III studies in CD.
Reproducibility of Flow Cytometry Through Standardization: Opportunities and Challenges
Authors: Kalina Tomas 
Published: October 2019

AbstractThere is an agreement in the field that interlaboratory reproducibility of flow cytometry measurements as well as the whole studies might be improved by a consensual use of methodological approach. Typically, a consensus is made on a crucial markers needed in the immunostaining panel, sometimes on the particular fluorochrome conjugates and rarely on a complete set of methods for sample preparation. The term “standardization” is used to describe the complete set of methodical steps, while “harmonization” is used for partial agreement on the method. Standardization can provide a platform for improved reproducibility of cytometry results over prolonged periods of time, across different sites and across different instruments. For the purpose of structured discussion, several desired aims are described: common interpretation of the immunophenotype definition of a target subset, accurate quantification, reproducible pattern of a multicolor immunophenotype, and reproducible intensity of all measured parameters. An overview of how standardization was approached by several large consortia is provided: EuroFlow, The ONE Study, Human Immunology Project Consortium (HIPC), and several other groups. Their particular aims and the tools adopted to reach those aims are noted. How those standardization efforts were adopted in the field and how the resulting outcome was evaluated is reviewed. Multiple challenges in the instrument hardware design, instrument setup tools, reagent design, and quality features need to be addressed to achieve optimal standardization. Furthermore, the aims of different studies vary, and thus, the reasonable requirements for standardization differ. A framework of reference for the reasonable outcomes of different approaches is offered. Finally, it is argued that complete standardization is important not only for the reproducibility of measurements but also for education, for quality assessment and for algorithmic data analysis. The different standardized approaches can and in fact should serve as benchmarking reference tools for the development of future flow cytometry studies. © 2019 International Society for Advancement of Cytometry
Incorporation of the Milan system in reporting salivary gland fine needle aspiration cytology—An insight into its value addition to the conventional system
Authors: Kaushik Richa , Bhatia Khyati , Sarin Haimanti , Gautam Dheeraj , Sarin Deepak 
Published: October 2019

AbstractBackgroundMilan System for Reporting Salivary Gland Cytology (MSRSGC) was introduced to standardise the terminology and reporting of salivary gland cytology. The purpose of our study was to compare the conventional system and the proposed Milan System to look for concordance rates in cytohistopathologic correlation and any value addition to the conventional system.MethodsThis was a retrospective cross sectional observational study. The fine needle aspiration cytology (FNAC) were reported in the conventional manner and were correlated with the surgical specimen. The cyto‐histopathological correlation was studied to look for concordance rates. FNAC were retrospectively reviewed and were categorised according to the Milan system. These reports were correlated with surgical specimen category wise and concordance rates, risk of neoplasm (RON), risk of malignancy (ROM) were calculated.ResultsSalivary gland FNAC done during the study period was 323 in number and histopathological correlation was available for 153 cases. The concordance rate of type specific diagnosis was 80.3% as per conventional system. With the application of Milan system, the concordance rates rose to 88.07% with an improvement of 6.67%(excluding non‐diagnostic). RON and ROM for non‐diagnostic (I)—50%, 50%; non‐neoplastic (II)—22%,0%; atypia of unknown significance (III)—66%, 11%; benign neoplasm (IVA)—98%, 3%; salivary gland neoplasm of uncertain malignant potential (IVB)—93%,14%; suspicious for malignancy (V)—100%, 60% and malignant (VI) was 100%, 94%.ConclusionThe broad categorisation provided by the Milan system represents the gross rate of malignancy and helps in deciding the management plan and eventual surgical plan. Thus, it adds value to conventional reporting of salivary gland cytology.