bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterosynaptic GABABReceptor Function within Feedforward Microcircuits Gates Glutamatergic Transmission in the Nucleus Accumbens Core
Authors: Manz Kevin M. , Baxley Andrew G. , Zurawski Zack , Hamm Heidi E. , Grueter Brad A. 
Published: October 2019

Complex circuit interactions within the nucleus accumbens (NAc) facilitate goal-directed behavior. Medium spiny neurons (MSNs) mediate NAc output by projecting to functionally divergent brain regions, a property conferred, in part, by the differential projection patterns of D1- and D2 dopamine receptor-expressing MSNs. Glutamatergic afferents to the NAc direct MSN output by recruiting feedforward inhibitory microcircuits comprised of parvalbumin (PV)-expressing interneurons (INs). Furthermore, the GABABheteroreceptor (GABABR), a Gi/o-coupled G-protein-coupled receptor, is expressed at glutamatergic synapses throughout the mesolimbic network, yet its physiological context and synaptic mechanism within the NAc remains unknown. Here, we explored GABABR function at glutamatergic synapses within PV-IN-embedded microcircuits in the NAc core of male mice. We found that GABABR is expressed presynaptically and recruits a noncanonical signaling mechanism to reduce glutamatergic synaptic efficacy at D1(+) and D1(−) (putative D2) MSN subtypes. Furthermore, PV-INs, a robust source of neuronal GABA in the NAc, heterosynaptically target GABABR to selectively modulate glutamatergic transmission onto D1(+) MSNs. These findings elucidate a new mechanism of feedforward inhibition and refine mechanisms by which GABABheteroreceptors modulate mesolimbic circuit function.SIGNIFICANCE STATEMENTGlutamatergic transmission in the nucleus accumbens (NAc) critically contributes to goal-directed behaviors. However, intrinsic microcircuit mechanisms governing the integration of these synapses remain largely unknown. Here, we show that parvalbumin-expressing interneurons within feedforward microcircuits heterosynaptically target GABABheteroreceptors (GABABR) on glutamate terminals. Activation of presynaptically-expressed GABABR decreases glutamatergic synaptic strength by engaging a non-canonical signaling pathway that interferes with vesicular exocytotic release machinery. These findings offer mechanistic insight into the role of GABABheteroreceptors within reward circuitry, elucidate a novel arm to feedforward inhibitory networks, and inform the growing use of GABABR-selective pharmacotherapy for various motivational disorders, including addiction, major depressive disorder, and autism (Cousins et al., 2002; Kahn et al., 2009; Jacobson et al., 2018; Stoppel et al., 2018; Pisansky et al., 2019).
Discussing issues of health promotion and research in the context of primary care during the ongoing austerity period: an exploratory analysis from two regions in Greece
Authors: Sbarouni Vicky , Petelos Elena , Kamekis Apostolos , Tzagkarakis Stylianos Ioannis , Symvoulakis Emmanouil K , Lionis Christos 
Published: October 2019

Background. In Greece, both Primary Health Care (PHC) system and National Health System (NHS) in general, were plagued by several inefficiencies even prior to the financial crisis; the imposed austerity measures dramatically worsened the level of health provision and access, especially for vulnerable social groups, resulting in an exacerbation of existing disparities and access gaps.
Aim and methods. The current branch study was conducted in two regions of Greece, namely Crete and Epirus, with the main aim of eliciting responses to gather baseline information regarding crucial PHC-related aspects, using questionnaires with dichotomous questions. Directors or managers (physicians who have been assigned administrative/governance duties), of the Primary Health Care Centres (PHCCs) in two Greek geographic and administrative regions of Crete and Epirus, were invited to participate and to contribute to the investigation of issues on the provision of prevention and health promotion services, e-health topics and primary care research. Thirty directors/managers were approached and twenty-eight agreed to participate. Data processing and analysis of the responses was performed for the completed questionnaires.
Results. Data analysis did not demonstrate a surprisingly substantial deviation in the average score of positive responses of directors/managers in the PHCCs of Crete in comparison to those of directors/managers in the PHCCs of Epirus. The findings show that several gaps exist in terms of prevention and health promotion resources and activities in both regions, while e-health, electronic health record (EHR) and telemedicine services are poorly developed.
Conclusion. The study confirms that the Greek PHC is characterized by several inefficiencies, which may affect the quality of the services provided. An overall deficit has been emerged for PHCCs in both regions, a fact that indicates crucial points lacking in terms of overall PHC provision, thus adversely impacting upon living conditions, health quality and prevention.
EDUKASI ZAT ADITIF MELALUI DEMONSTRASI KIMIA DI SDN BUANGNGARIUNG WADO
Authors: Kulsum Qistholina Dewi , Rouf Sidiq Abdull , Irwansyah Ferli Septi 
Published: October 2019

Proses edukasi ini dilakukan karena dilihat dari kondisi umum di Dusun Kampung Baru yang merupakan relokasi dari waduk Jati Gede sehingga keadaan ekonomi rendah yang menunjang banyaknya konsumsi makanan instan yang kadar zat aditifnya tinggi sehingga tujuan edukasi ini agar anak remaja di Dusun Kampung Baru mengetahui bahaya zat aditif yang sering dikonsumsi dalam kehidupan. Sedangkan metode yang digunakan yaitu demonstrasi dan ceramah agar siswa dapat menyimak materi tidak hanya berupa teoritik melainkan aplikatif dan mudah untuk mengurangi konsumsi zat additive. Hasil dari edukasi ini siswa mengetahui ciri bakso atau makanan lain yang mengandung boraks dengan uji kunyit ditandai perubahan warna pada kertas saring yang telah ditambahkan ekstrak kunyit, dari demonstrasi soda meluncur siswa mengenal reaksi minuman bersoda bila dicampurkan dengan makanan yang bermicin kadar tinggi, akan menimbulkan perut kembung dan gangguan pencernaan.
Prevalence of NRAS Mutation, PD-L1 Expression and Amplification, and Overall Survival Analysis in 36 Primary Vaginal Melanomas
Authors: Wang Hai-Yun , Wu Xiao-Yan , Zhang Xiao , Yang Xin-Hua , Long Ya-Kang , Feng Yan-Fen , Wang Fang 
Published: October 2019

Abstract

Background
Primary vaginal melanomas are uncommon and aggressive tumors with poor prognosis, and the development of new targeted therapies is essential. This study aimed to identify the molecular markers occurring in these patients and potentially improve treatment strategies.

Materials and Methods
The clinicopathological characteristics of 36 patients with primary vaginal melanomas were reviewed. Oncogenic mutations in BRAF, KIT, NRAS, GNAQ and GNA11 and the promoter region of telomerase reverse transcriptase (TERT) were investigated using the Sanger sequencing. The expression and copy number of programmed death-ligand 1 (PD-L1) were also assessed.

Results
Mutations in NRAS, KIT, and TERT promoter were identified in 13.9% (5/36), 2.9% (1/34), and 5.6% (2/36) of the primary vaginal melanomas, respectively. PD-L1 expression and amplification were observed in 27.8% (10/36) and 5.6% (2/36) of cases, respectively. PD-L1 positive expression and/or amplification was associated with older patients (p = .008). Patients who had NRAS mutations had a poorer overall survival compared with those with a wild-type NRAS (33.5 vs. 14.0 months; hazard ratio [HR], 3.09; 95% CI, 1.08–8.83). Strikingly, two patients with/without PD-L1 expression receiving immune checkpoint inhibitors had a satisfying outcome. Multivariate analysis demonstrated that &gt;10 mitoses per mm2 (HR, 2.96; 95% CI, 1.03–8.51) was an independent prognostic factor.

Conclusions
NRAS mutations and PD-L1 expression were most prevalent in our cohort of primary vaginal melanomas and can be potentially considered as therapeutic targets.
PERSPEKTIF AL-QUR’AN DAN UNDANG-UNDANG TENTANG GURU PROFESIONAL
Authors: Wasehudin Wasehudin 
Published: October 2019

This research is motivated by a high demand in the world of education, especially the professional educator. Anxiety of students when they are in class or classroom is considered a prison for the students is evidence of a failure in education. For that reason the idea in searching professional educator model from The Qur’an perspective should always be sought; how the pattern and model of professional ideal educator in the Islamic view. The approach used in this research is qualitative; the data used is documentary data both secondary and primary date which then dissected by using descriptive analysis approach. In the Qur’an perspective, especially in Sura Ali Imran: 159, it is stated that the professional teacher is able to master the material and methodology simultaneously. They can not be separated from one another. In addition, the teacher is said to be a professional when he or she becomes a role model which must be obeyed (digugu) and imitated (ditiru) when he is both in the environment of the educational institution and in the society where he lives and interacts. Penelitian ini dilatarbelakangi oleh tuntutan yang begitu besar dalam dunia pendidikan terutama sekali guru profesinal. Kegundahan para peserta didik ketika berada dalam ruang kelas atau kelas dianggap sebagai penjara bagi para siswanya merupakan bukti adanya kegagalan dalam sebuah pendidikan. Untuk itu gagasan dalam pencarian model pendidik profesional perspektif Al-Qur’an harus senantiasa dicari; bagaimana pola maupun model guru profesional yang ideal dalam pandangan Islam. Pendekatan yang digunakan dalam penelitian ini bersifat kualitatif; data yang digunakan adalah data yang bersifat dokumenter baik data yang bersifat sekunder maupun primer yang kemudian dibedah dengan menggunakan pendekatan deskriptif analisis. Perspektif Al-Qur’an, khususnya dalam Surat Ali Imran: 159, menyatakan bahwa guru dikatakan profesional apabila ia mampu menguasai materi dan metodologi secara bersamaan. Keduanya tidak bisa dipisahkan antara satu dengan yang lainnya. Selain daripada itu guru dikatakan professional manakala ia menjadikan role model (uswah hasanah) yang harus digugu dan ditiru baik ketika ia berada dalam lingkungan institusi pendidikan maupun dalam lingkungan masyarakat dimana ia tinggal dan berinteraksi.
IMPLEMENTASI METODE MY Q-MAP DALAM MENINGKATKAN HAFALAN ALQURAN
Authors: Widiastuti Dara , Abdussalam Aam , Sumarna Elan 
Published: October 2019

Abstract. This research is motivated by the difficulty of memorizing the Qur’an and maintaining memorization. This study aims to determine the application of the My Q-Map method in improving the memorization of the Qur’an in Pondok Tahfidz Bintang Qur’an Cirebon. Data collection techniques was carried out by interview, observation, and study documentation. Data analysis was performed by data reduction, data presentation, drawing conclusions and coding. From the results of this study it is known that the implementation of the My Q-Map method in Pondok Tahfidz Bintang Quran Cirebon refers to the curriculum that has been created by the Pondok (Islamic boarding schoool) itself. Activities of students and teachers in implementing the My Q-Map method in memorizing the Qur’an began with the opening, memorization, and evaluation. The advantage of this method is that it can help students overcome obstacles in memorization such as forgetfulness, depression, and other personal obstacles. In addition, this method can help students understand the meaning and remember the location of the verse so that memorization of the Qur’an feels more memorable and makes memorization more strongly bound. Overall this method has been quite successful in helping students improve memorization of the Qur’an. Abstrak. Penelitian ini dilatarbelakangi oleh sulitnya menghafal Alquran dan menjaga hafalannya. Penelitian ini bertujuan untuk mengetahui penerapan metode My Q-Map dalam meningkatkan hafalan Alquran di Pondok Tahfidz Bintang Quran Cirebon. Teknik pengumpulan data dilakukan dengan cara wawancara, observasi, dan studi dokumentasi. Analisis data dilakukan dengan cara reduksi data, penyajian data, penarikan kesimpulan dan koding. Dari hasil penelitian ini diketahui bahwa implementasi metode My Q-Map di Pondok Tahfidz Bintang Quran Cirebon mengacu kepada kurikulum yang telah dibuat oleh pondok itu sendiri. Aktivitas santri dan guru dalam mengimplementasikan metode My Q-Map dalam kegiatan menghafalkan Alquran dimulai dengan pembukaan, kegiatan menghafal, dan evaluasi. Kelebihan metode ini adalah dapat membantu mengatasi kendala santri dalam menghafal seperti mudah lupa, depresi, dan kendala personal lainnya. Di samping itu, metode ini dapat membantu santri memahami makna dan mengingat letak ayat sehingga hafalan Alquran terasa lebih berkesan dan membuat hafalan lebih kuat terikat. Secara keseluruhan metode ini sudah cukup berhasil dalam membantu santri meningkatkan hafalan Alquran.
Maquiavelismo e sua Relação com Atividades Contraproducentes nos Estudantes de Ciências Contábeis
Authors: ALVES RONILSON SOARES , Puppin Lorenza , Nascimento Eduardo Mendes , Da Cunha Jacqueline Veneroso Alves 
Published: October 2019

Objetivo: o objetivo desta pesquisa é mensurar e classificar traços de personalidade maquiavelista com o propósito de associá-los a comportamento contraproducente em futuros profissionais de contabilidade.
Método: aplicação de 137 questionários em 2017, à alunos de 4 instituições de Ensino Superior de Minas Gerais (duas públicas e duas privadas) . Para análise conteúdo, os dados foram utilizados numa analise descritiva e quantitativa, e utilização de testes estatísticos para o estabelecimento de relações entre as respostas obtidas.
Resultados: os resultados apontam para a preponderância de um perfil maquiavelista moderado, entre os futuros profissionais de contabilidade, porém não há evidências empíricas nesta amostra que possam levar a conclusão de que o maquiavelismo esteja relacionado ao comportamento contraproducente. A maioria dos entrevistados se autodeclaram com perfil baixo de contraproducência organizacional e interpessoal e há uma forte associação entre essas duas variáveis. Os resultados ainda permitem inferir que o traço de maquiavelismo parece ser em média mais evidente nos homens do que entre as mulheres.
Contribuições: entender que o perfil maquiavelista moderado não apresenta necessariamente comportamento contraproducente contribui com a área de recursos humanos em seus processos seletivos e avaliações periódicas.
Yoga Improves Balance and Low-Back Pain, but Not Anxiety, in People with Parkinson’s Disease
Authors: Myers Peter S. , Harrison Elinor C. , Rawson Kerri S. , Horin Adam P. , Sutter Ellen N. , McNeely Marie E. , Earhart Gammon M. 
Published: October 2019

Abstract
Individuals with Parkinson’s disease (PD) experience postural instability, low-back pain (LBP), and anxiety. These symptoms increase the risk of falls and decrease quality of life. Research shows yoga improves balance and decreases LBP and anxiety in healthy adults, but its effects in PD are poorly understood. All participants were part of a larger intervention study. Participants received pretest and posttest evaluations, including the Balance Evaluation Systems Test (BESTest), Beck Anxiety Inventory (BAI), and Revised Oswestry Disability Index (ROSW). Total scores for each measure, as well as individual balance system section scores from the BESTest (biomechanical constraints, stability limits/verticality, transitions/anticipatory, reactive, sensory orientation, and stability in gait) were compared within groups pre- to posttest. Participants in the yoga group (n = 13) completed a twice-weekly 12-week yoga interve n t i o n , whereas controls (n = 13) continued their usual routines for 12 weeks. Both the yoga (Z = −3.20, p = 0.001) and control (Z = −2.10, p = 0.040) groups improved on the BESTest total score. The control group showed no changes in individual balance systems, whereas the yoga group improved in stability limits/verticality (Z = −2.3, p = 0.020), transitions/ anticipatory (Z = −2.50, p = 0.010), reactive (Z = −2.70, p = 0.008), and sensory orientation (Z = −2.30, p = 0.020). ROSW decreased in the yoga group only (Z = −2.10, p = 0.030). BAI did not change in either group. Yoga is a nonpharmacological intervention that can improve balance and LBP in people with PD. This study demonstrated that yoga is feasible for people with PD, and participants reported high levels of enjoyment and intent to practice yoga after the study.
Asupan vitamin B6, B9, B12 memiliki hubungan dengan risiko penyakit kardiovaskular pada lansia
Authors: Akhirul Akhirul , Chondro Fransisca 
Published: October 2019

LATAR BELAKANGIndonesia akan memasuki periode lansia (aging), dimana 10% penduduk akan berusia 60 tahun ke atas, di tahun 2020. Bertambahnya usia, penyakit tidak menular banyak muncul seperti hipertensi, stroke, dan diabetes melitus (DM). Menurut penelitian yang dilakukan oleh Gugun, asupan gizi atau mikronutrien antara lain asam folat, vitamin B6, dan B12 berpengaruh terhadap terjadinya resiko penyakit kardiovaskular dikarenakan asupan mikronutrien tersebut dapat menurunkan kadar homosistein yang berperan dalam pembentukan aterotrombosis.
METODEPenelitian ini dilakukan menggunakan metode analitik observasional dengan pendekatan cross sectional. Pengambilan sampel dilakukan di Kelurahan Jelambar Baru RW 01 pada bulan September hingga Oktober 2018 dengan metode consecutive non random. Jumlah responden sebanyak 92 orang. Pengambilan data menggunakan data primer. Analisis data menggunakan uji Fisher dengan tingkat kemaknaan (p)<0.05.
HASILTerdapat hubungan yang bermakna secara statistik antara asupan vitamin B6, B9, dan B12 dengan risiko kardiovaskular pada lansia. Asupan vitamin B6 dengan kategori cukup mempunyai risiko rendah mengalami penyakit kardiovaskular dengan nilai kemaknaan (p=0.000), vitamin B9 asupan kategori kurang memiliki risiko sedang mengalami penyakit kardiovaskular (p=0.001), dan asupan vitamin B12 dengan asupan kategori kurang mempunyai risiko sedang mengalami risiko penyakit kardiovaskular (p=0.017).
KESIMPULANDari hasil analisis data didapatkan hubungan antara asupan gizi vitamin B6, B9, dan B12 dengan risiko kardivaskular pada lansia, dimana asupan cukup vitamin B6, B9, dan B12 mengakibatkan risiko rendah untuk menderita penyakit kardiovaskular sedangkan asupan kurang dari vitamin B6, B9, dan B12 mengakibatkan risiko sedang dan tinggi untuk menderita penyakit kardiovaskular.
THE INDIVIDUAL WORK PERFORMANCE SCALE: A PSYCHOMETRIC STUDY AND ITS APPLICATION FOR EMPLOYEE PERFORMANCE
Authors: Ramdani Zulmi , Marliani Rosleny , Rahman Agus Abdul 
Published: October 2019

Purpose: This research aims to get an individual work performance scale of the modified version which is more acceptable and has a good psychometric property.
Methodology: This study was conducted using a modified measuring instrument approach. Researchers use existing theories and then make items according to the context in which this research will be conducted. The advantage of this modification approach is getting a more comprehensive understanding of the subject we are researching.
Main Findings: Of the 303 employees that were tested in the research, the modification scale of the individual work performance has a good psychometric property with the criteria of reliability more than 0.8 and the fit model that has a good item with RMSEA score (0.062). Other than that, the modification scale of individual work performance shows a good convergent validity with presenteeism and correlate with job burnout.
Applications of this study: The Individual Work Performance Scale has a comprehensive methodology and good psychometric properties. This instrument is appropriate to be the general instrument for seeing the employee situation. In addition, this instrument can also be used as a set of tests that are suitable for use by those who will conduct an assessment of employee performance.
Novelty: This scale was made as a form of development from previous research which did not explore and develop forms of assessment that were specific to an employee's performance. There is not much-related research that focuses on many dimensions that are actually important to assess in employee performance.
Toward Linguistically and Culturally Responsive Teaching in the French as a Second Language Classroom
Authors: Wernicke Meike 
Published: October 2019

In English-majority contexts such as British Columbia, French second language (FSL) teachers are increasingly encountering students who are also learning French in addition to English and their home languages. Research findings show that dual language learners are successfully supported through multilingual pedagogies that acknowledge and explicitly value students’ prior learning experiences and multilingual knowledge as an integral resource in their language learning. This poses a particular challenge for FSL teacher candidates whose own language learning experiences have been shaped by institutional bilingualism and monoglossic approaches in bilingual education contexts. This article sets out the implications of this challenge and then describes a teacher education course that specifically addresses the Teaching of English as an additional language (TEAL) with teacher candidates in an elementary French specialist cohort program at a university in British Columbia. The discussion provides an overview of the course and then describes some of the ways in which critical language awareness can be fostered among FSL teacher candidates’ strategies to encourage a linguistically and culturally responsive approach to FSL teaching.
Dans un contexte majoritairement anglophone comme celui de la Colombie-Britannique, les enseignantes et enseignants de français langue seconde (FLS) se trouvent de plus en plus souvent face à des élèves qui apprennent le français en plus de l’anglais et de la langue qu’ils ou elles parlent à la maison. Les recherches démontrent que les élèves qui apprennent deux langues bénéficient de pédagogies multilingues efficaces qui reconnaissent et mettent explicitement en valeur leurs expériences d’apprentissage antérieures et leurs connaissances multilingues, et ce, en en faisant une partie intégrante des ressources dans lesquelles ils peuvent puiser au cours de leur apprentissage linguistique. Cela pose un défi particulier pour les enseignantes et enseignants de FLS en formation dont les expériences d’apprentissage linguistique ont été façonnées par le bilinguisme institutionnel et une conception monoglossique des contextes éducatifs bilingues. Le présent article expose les implications de ce défi et décrit ensuite un cours de formation d’enseignantes et d’enseignants qui porte spécifiquement sur l’enseignement de l’anglais comme langue complémentaire (TEAL) dans le cadre d’un programme offert par une université britannico-colombienne à une cohorte de spécialistes de la langue française au niveau élémentaire. La discussion présente un aperçu du cours et décrit ensuite certaines façons de favoriser le développement d’une conscience linguistique critique dans le cadre des stratégies des enseignantes et enseignants de FLS en formation afin de promouvoir le développement d’une conception de l’enseignement qui prenne en compte les réalités linguistiques et culturelles.