bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of resuscitation fluid bag size availability on volume of fluid administration in the intensive care unit
Authors: Horst S. , Kawati R. , Rasmusson J. , Pikwer A. , Castegren M. , Lipcsey M. 
Published: May 2018

Background
Iatrogenic fluid overload is associated with increased mortality in the intensive care unit (ICU). Decisions on fluid therapy may, at times, be based on other factors than physiological endpoints. We hypothesized that because of psychological factors volume of available fluid bags would affect the amount of resuscitation fluid administered to ICU patients.MethodsWe performed a prospective intervention cross‐over study at 3 Swedish ICUs by replacing the standard resuscitation fluid bag of Ringer's Acetate 1000 mL with 500 mL bags (intervention group) for 5 separate months and then compared it with the standard bag size for 5 months (control group). Primary endpoint was the amount of Ringer's Acetate per patient during ICU stay. Secondary endpoints were differences between the groups in cumulative fluid balance and change in body weight, hemoglobin and creatinine levels, urine output, acute kidney failure (measured as the need for renal replacement therapy, RRT) and 90‐day mortality.ResultsSix hundred and thirty‐five ICU patients were included (291 in the intervention group, 344 in the control group). There was no difference in the amount of resuscitation fluid per patient during the ICU stay (2200 mL [1000‐4500 median IQR] vs 2245 mL [1000‐5630 median IQR]), RRT rate (11 vs 9%), 90‐day mortality (11 vs 10%) or total fluid balance between the groups. The daily amount of Ringer's acetate administered per day was lower in the intervention group (1040 (280‐2000) vs 1520 (460‐3000) mL; P = .03).ConclusionsThe amount of resuscitation fluid administered to ICU patients was not affected by the size of the available fluid bags. However, altering fluid bag size could have influenced fluid prescription behavior.
Placental growth factor as an indicator of fetal growth restriction in late‐onset small‐for‐gestational age pregnancies
Authors: Anderson Ngaire , De Laat Monique , Benton Samantha , von Dadelszen Peter , McCowan Lesley 
Published: May 2018

BackgroundAt‐risk small‐for‐gestational age (SGA) pregnancies in New Zealand are identified using Doppler ultrasound; fetuses with Doppler abnormalities are considered growth restricted (FGR). Low maternal placental growth factor (PlGF) has also been associated with late‐onset FGR.AimsTo investigate whether low PlGF at diagnosis of late‐onset SGA identifies the same fetuses classified FGR by detailed Doppler studies, and the association between low PlGF and adverse pregnancy outcomes.MethodsAmong an historical database of normotensive suspected SGA pregnancies (fetal abdominal circumference <10th percentile) ≥32 weeks gestation, the ability of low PlGF (<5th percentile) to identify FGR infants was investigated. ‘Initial FGR’ was an abnormal umbilical artery resistance index (RI) or estimated fetal weight <3rd customised centile. ‘Secondary FGR’ was abnormal internal carotid RI, cerebro‐placental ratio and/or mean uterine artery RI. Development of hypertensive disease and adverse perinatal outcomes were compared by PlGF status.ResultsOf 136 SGA pregnancies, 56 (41.1%) had initial FGR. Of the remaining, 20 (25.0%) had secondary FGR, 17 (21.3%) low PlGF. The sensitivity of low PlGF identifying secondary FGR was 0.30 (95% CI 0.14–0.50), specificity 0.83 (0.70–0.92), positive predictive value 0.47 (0.23–0.72) and negative predictive value 0.70 (0.57–0.81). Overall, low PlGF occurred in 44/136 (32.4%) pregnancies and was associated with gestational hypertensive disease (63.6% vs 15.2%, P < 0.01), adverse perinatal outcome (34.1% vs 15.2%, P = 0.01) and very low birthweight (customised centile 2.2 vs 6.8, P < 0.01).ConclusionsAt diagnosis of late‐onset SGA, low PlGF was poor at identifying Doppler‐defined FGR. Low PlGF identified pregnancies at risk of hypertensive disease, adverse perinatal outcome and very low birthweight.
Building Beyond the Bypass Road: Urban Migration, Ritual Eating, and the Fate of the Joint Family in Patna, India
Authors: Kantor Hayden S. 
Published: May 2018

ABSTRACTThe anthropology of urban migration in South Asia has emphasized the plight of marginalized people and conflicts over public space. But the precarity of agriculture and inadequacy of basic state services has increasingly compelled rural middle‐class families in Bihar, India, to establish a foothold in the country's booming cities. Because they aim to remain located in both the urban and rural spheres, urban migration reconfigures kinship relations so that the joint family household becomes a non‐cohabitating entity. Constructing a house in the city depends on rural consumption practices that are distinct from the individual‐oriented consumerism of the urban middle class. The gr̥h praveś, the Hindu house consecration ceremony and feast, legitimizes this transition. The hosts negotiate their hybrid identity as urban migrants through the event's food practices. For instance, adulteration scandals have prompted concerns about provisioning milk in the city. The consumption of milk‐based specialty foods during the gr̥h praveś reflects the family's effort to deploy nourishing, familiar foods that reassert ties to their village community while also signaling aspirations to prosperity and a modern, cosmopolitan identity. Moments of ritual excess extend overflowing hospitality to guests human and divine, providing material proof of the family's unity and ambitions. [urban migration, feasting, house construction, ritual, kinship]
Letter: concordance of SVR4 and SVR12 following direct‐acting anti‐viral treatment in Egypt
Authors: El Kassas M. , Funk A. L. , Abd El Latif Y. , Vasiliu A. , Sherief A. , Shimakawa Y. , Youssef N. , El Tahan A. , Elbadry M. , Farid A. M. , El Shazly Y. , Doss W. , Esmat G. , Fontanet A. 
Published: May 2018

Linked ContentThis article is linked to Omar et al paper. To view this article visit https://doi.org/10.1111/apt.14428.
Editorial: validating reliability of the eosinophilic oesophagitis histological scoring system (EOE‐HSS)—an important first step
Authors: Conner J. R. , Kirsch R. 
Published: May 2018

Linked contentThis article is linked to Warners et al and Pai et al papers. To view these articles visit https://doi.org/10.1111/apt.14559 and https://doi.org/10.1111/apt.14658.
Editorial: genotype 3 HCV—who still needs ribavirin in a pan‐genotypic era? Authors’ reply
Authors: von Felden J. , Vermehren J. , Schulze zur Wiesch J. , Sarrazin C. , Christensen S. 
Published: May 2018

Linked ContentThis article is linked to von Felden et al and Sadler papers. To view these articles visit https://doi.org/10.1111/apt.14592 and https://doi.org/10.1111/apt.14646.
Letter: adoption of uniform nomenclature is crucial for estimating the true risk of HBV reactivation in patients treated with direct‐acting antivirals for hepatitis C
Authors: Mücke M. M. , Mücke V. T. , Vermehren J. 
Published: May 2018

Linked ContentThis aritcle is linked to Butt et al paper. To view this article visit https://doi.org/10.1111/apt.14426.
Editorial: validating reliability of the eosinophilic oesophagitis histological scoring system (EOE‐HSS)—an important first step. Authors’ reply
Authors: Pai R. K. , Bredenoord A. J. , Feagan B. G. , Jairath V. 
Published: May 2018

Linked contentThis article is linked to Warners et al and Conner and Kirsch papers. To view these articles https://doi.org/10.1111/apt.14559 and https://doi.org/10.1111/apt.14633.
Editorial: faecal incontinence—the hidden burden of inflammatory bowel diseases. Authors' reply
Authors: Vollebregt P. F. , van Bodegraven A. A. , Markus‐de Kwaadsteniet T. M. L. , van der Horst D. , Felt‐Bersma R. J. F. 
Published: May 2018

Linked contentThis article is linked to Vollebregt et al and Cañete and Domènech papers. To view these articles visit https://doi.org/10.1111/apt.14599 and https://doi.org/10.1111/apt.14637.
Editorial: let's take a break from studying the PPI‐fracture association—Authors’ reply
Authors: Torvinen‐Kiiskinen S. , Tolppanen A.‐M. , Koponen M. , Tanskanen A. , Tiihonen J. , Hartikainen S. , Taipale H. 
Published: May 2018

Linked ContentThis article is linked to Torvinen‐Kiiskinen et al and Targownik papers. To view these articles visit https://doi.org/10.1111/apt.14589 and https://doi.org/10.1111/apt.14640.
Letter: serum HBcrAg is a useful marker for disease monitoring, predicting treatment response and disease outcome of chronic hepatitis B virus infection—authors' reply
Authors: Mak L.‐Y. , Yuen M.‐F. 
Published: May 2018

Linked contentThis article is linked to Mak et al and Wang et al papers. To view these articles visit https://doi.org/10.1111/apt.14376 and https://doi.org/10.1111/apt.14673.
Randomised clinical trial: faecal microbiota transplantation by colonoscopy plus vancomycin for the treatment of severe refractory Clostridium difficile infection—single versus multiple infusions
Authors: Ianiro G. , Masucci L. , Quaranta G. , Simonelli C. , Lopetuso L. R. , Sanguinetti M. , Gasbarrini A. , Cammarota G. 
Published: May 2018

SummaryBackgroundFaecal microbiota transplantation (FMT) is a highly effective treatment against recurrent Clostridium difficile infection. Far less evidence exists on the efficacy of FMT in treating severe Clostridium difficile infection refractory to antibiotics.AimTo compare the efficacy of two FMT‐based protocols associated with vancomycin in curing subjects with severe Clostridium difficile infection refractory to antibiotics.MethodsSubjects with severe Clostridium difficile infection refractory to antibiotics were randomly assigned to one of the two following treatment arms: (1) FMT‐S, including a single faecal infusion via colonoscopy followed by a 14‐day vancomycin course, (2) FMT‐M, including multiple faecal infusions plus a 14‐day vancomycin course. In the FMT‐M group, all subjects received at least two infusions, while those with pseudomembranous colitis underwent further infusions until the disappearance of pseudomembranes. The primary outcome was the cure of refractory severe Clostridium difficile infection.ResultsFifty six subjects, 28 in each treatment arm, were enrolled. Twenty one patients in the FMT‐S group and 28 patients in the FMT‐M group were cured (75% vs 100%, respectively, both in per protocol and intention‐to‐treat analyses; P = 0.01). No serious adverse events associated with any of the two treatment protocols were observed.ConclusionsA pseudomembrane‐driven FMT protocol consisting of multiple faecal infusions and concomitant vancomycin was significantly more effective than a single faecal transplant followed by vancomycin in curing severe Clostridium difficile infection refractory to antibiotics. Clinical‐Trials.gov registration number: NCT03427229.
Novel operative approach to double primary cancers of the breast and thyroid and its effects on cosmesis and the accuracy of follow‐up examinations
Authors: Tori Masayuki , Shimo Toshirou , Yoshidome Katsuhide 
Published: June 2018

AbstractFor the treatment of double primary cancer of the breast and thyroid, endoscopic thyroidectomy might be an excellent option in terms of cosmesis; however, it may not offer curability, and it makes the accuracy of follow‐up examinations difficult. The postoperative scars after endoscopic thyroidectomy may modify the estimation of recurrence. To achieve improve cosmesis and the accuracy of follow‐up examination, we developed a novel method for thyroid surgery: hybrid‐type endoscopic thyroidectomy (HET). Here we report two cases of double primary cancer, one synchronous and the other metachronous. HET lobectomy and HET total thyroidectomy were performed in combination with some modifications of breast surgery. In each case, the postoperative course was uneventful, and cosmetic satisfaction was very high. Furthermore, there were no problems during the follow‐up period. Based on our results, HET could become a standardized treatment of double primary cancers.
Nicotinic acetylcholine receptors
Authors: Wonnacott Sue , Bermudez Isabel , Millar Neil S , Tzartos Socrates J 
Published: May 2018

This themed section of the British Journal of Pharmacology is the product of a conference that focussed on nicotinic ACh receptors (nAChRs) that was held on the Greek island of Crete from 7 to 11 May 2017. ‘Nicotinic acetylcholine receptors 2017’ was the fourth in a series of triennial international meetings that have provided a regular forum for scientists working on all aspects of nAChRs to meet and to discuss new developments. In addition to many of the regular participants, each meeting has also attracted a new group of scientists working in a fast‐moving area of research. This themed section comprises both review articles and original research papers on nAChRs.Linked ArticlesThis article is part of a themed section on Nicotinic Acetylcholine Receptors. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.11/issuetoc/
Recent advances in targeting ion channels to treat chronic pain
Authors: Stevens Edward B , Stephens Gary J 
Published: May 2018

Linked ArticlesThis article is part of a themed section on Recent Advances in Targeting Ion Channels to Treat Chronic Pain. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.12/issuetoc
Correspondence of Pubertal Neuroendocrine and Tanner Stage Changes in Boys and Associations With Substance Use
Authors: Marceau Kristine , Kirisci Levent , Tarter Ralph E. 
Published: May 2018

This study examined correspondence between timing (onset) and tempo (rate) of sexual maturation prospectively (average ages 11–16 years) measured by gonadal hormones and secondary sex characteristics (Tanner stage) using dual‐process models, and associations of these measures with substance use (SU) involvement in boys at age 16 years (N = 534, 77.5% White/22.5% Non‐White). All measures of timing were highly associated. Early Tanner stage timing often predicted slower increases in gonadal steroids, but not the reverse; patterns varied by ethnicity. Hormone and Tanner stage measures were similar earlier in development but diverged later in development. In White boys only, early timing of the pubertal rise in testosterone was associated with increased SU involvement, suggesting a physiological rather than psychosocial mechanism of association.
A Versatile Parameterization for Measured Material Manifolds
Authors: Soler Cyril , Subr Kartic , Nowrouzezahrai Derek 
Published: June 2018

AbstractA popular approach for computing photorealistic images of virtual objects requires applying reflectance profiles measured from real surfaces, introducing several challenges: the memory needed to faithfully capture realistic material reflectance is large, the choice of materials is limited to the set of measurements, and image synthesis using the measured data is costly. Typically, this data is either compressed by projecting it onto a subset of its linear principal components or by applying non‐linear methods. The former requires many components to faithfully represent the input reflectance, whereas the latter necessitates costly extrapolation algorithms. We learn an underlying, low‐dimensional non‐linear reflectance manifold amenable to rapid exploration and rendering of real‐world materials. We can express interpolated materials as linear combinations of the measured data, despite them lying on an inherently non‐linear manifold. This allows us to efficiently interpolate and extrapolate measured BRDFs, and to render directly from the manifold representation. We exploit properties of Gaussian process latent variable models and use our representation for high‐performance and offline rendering with interpolated real‐world materials.
Self‐similarity Analysis for Motion Capture Cleaning
Authors: Aristidou A. , Cohen‐Or D. , Hodgins J. K. , Shamir A. 
Published: June 2018

AbstractMotion capture sequences may contain erroneous data, especially when the motion is complex or performers are interacting closely and occlusions are frequent. Common practice is to have specialists visually detect the abnormalities and fix them manually. In this paper, we present a method to automatically analyze and fix motion capture sequences by using self‐similarity analysis. The premise of this work is that human motion data has a high‐degree of self‐similarity. Therefore, given enough motion data, erroneous motions are distinct when compared to other motions. We utilizemotion‐wordsthat consist of short sequences of transformations of groups of joints around a given motion frame. We search for the K‐nearest neighbors (KNN) set of each word using dynamic time warping and use it to detect and fix erroneous motions automatically. We demonstrate the effectiveness of our method in various examples, and evaluate by comparing to alternative methods and to manual cleaning.
Introduction
Authors: Brown G. 
Published: May 2018

AbstractThe objective of this special issue of Colorectal Disease is to collate the opinions of a global group of experts on the key issues in colorectal cancer that we all felt needed improving for the benefit of patients with this disease. More than 150 experts from all over the world have contributed to this edition. The symposium proceedings do not just reflect the opinions of the expert panel members but also the views of an invited expert audience. The format of the day was to invite the lead experts to give short presentations, followed by a round table discussion, and voting by the entire expert audience. The result was to agree the improvements that needed to be made, not just in the UK but globally.
A personal perspective of the development of MRI for Total Mesorectal Excision surgery
Authors: Heald R. J. 
Published: May 2018

AbstractIn this personal account Professor Heald discusses the international implementation of total mesorectal excision for rectal cancer and the development of a generation of “specimen‐orientated” surgeons. He describes the importance of the surgeon, radiologist and pathologist working together to improve techniques in all three disciplines and the research challenges for the future.
Session 1: The evolution and development of the multidisciplinary team approach: USA, European and UK experiences – what can we do better?
Authors: Wale A. , Wexner S. D. , Saur N. M. , Massarotti H. , Laurberg S. , Kennedy E. , Rockall A. , Sebag‐Montefiore D. , Brown G. 
Published: May 2018

AbstractThe process of determining the best treatments that should be offered to patients with newly diagnosed colon and rectal cancer remains highly variable around the world. The aim of this expert review was to agree the key elements of good quality preoperative treatment decision making.
Session 2: What causes liver metastases – lymph nodes or is it something else?
Authors: Siddiqui M. , Nagtegaal I. , Santiago I. , Knijn N. , Berho M. , Mirnezami A. , Rao S. , Brown G. 
Published: May 2018

AbstractThe traditional view of progression of disease in cancer is the sequential spread of tumour to locoregional lymph nodes and then to distant metastases. However, this view may need to be challenged and modern pathology techniques such as immunohistochemistry and tumour profiling can provide us with a greater insight into the pathways and mechanisms of distant spread. Professor Nagtegaal discusses the evidence for reconsidering the current paradigm and reflects on the need for further investigation into mechanisms of distant metastatic spread.
Session 2: Extramural vascular invasion and extranodal deposits: should they be treated the same?
Authors: Balyasnikova S. , Haboubi N. , Wale A. , Santiago I. , Morgan M. , Cunningham D. , Mason M. , Berho M. , Brown G. 
Published: May 2018

AbstractProfessor Nagtegaal has already highlighted that lymph nodes are probably not responsible for the development of liver metastases. If they are not, then is there another mechanism? Professor Haboubi addresses the question of extranodal deposits – their frequency and their importance in the development of metastatic disease. The experts review the evidence and discuss whether this information will alter treatment decisions and staging systems in the future.
Session 3: Intra‐operative radiotherapy – creating new surgical boundaries
Authors: Patel A. , Chang G. , Wale A. , Chong I. , Rutten H. , Nicholls J. , Hawkins M. , Steele R.J.C. , Marks J. , Brown G. 
Published: May 2018

AbstractIn patients with advanced and recurrent colorectal cancer, surgical resection with clear margins is the greatest challenge and is limited by known anatomical constraints. Preoperative or intra‐operative assessment of the limits of surgical dissection may help to explore the possibility of improving resectability through either targeted external beam radiotherapy or intra‐operative radiotherapy. Professor Chang reviews the evidence base and potential advantages and disadvantages of this approach, whilst the expert panel agree a consensus on the evidence for assessment and therapy of such patients.
Session 3: Beyond TME and radiotherapy MRI evaluation of rectal cancer treatment response
Authors: Patel U. B. , Blomqvist L. , Chau I. , Nicholls J. , Brown G. 
Published: May 2018

AbstractMagnetic resonance imaging plays an increasingly important role in evaluating the effect of cancer treatment. Imaging alone cannot predict pathological complete response and imaging interpretation should be combined with clinical information and endoscopy findings to predict complete response. Professor Blomqvist reviews current and future imaging techniques and whether the quantitative can add significant or important prognostic information over the current qualitative techniques.
Metformin use in the first year after kidney transplant, correlates, and associated outcomes in diabetic transplant recipients: A retrospective analysis of integrated registry and pharmacy claims data
Authors: Vest L. S. , Koraishy F. M. , Zhang Z. , Lam N. N. , Schnitzler M. A. , Dharnidharka V. R. , Axelrod D. , Naik A. S. , Alhamad T. A. , Kasiske B. L. , Hess G. P. , Lentine K. L. 
Published: May 2018

AbstractWhile guidelines support metformin as a therapeutic option for diabetic patients with mild‐to‐moderate renal insufficiency, the frequency and outcomes of metformin use in kidney transplant recipients are not well described. We integrated national U.S. transplant registry data with records from a large pharmaceutical claims clearinghouse (2008‐2015). Associations (adjusted hazard ratio, 95% LCLaHR95% UCL) of diabetes regimens (with and excluding metformin) in the first year post‐transplant with patient and graft survival over the subsequent year were quantified by multivariate Cox regression, adjusted for recipient, donor, and transplant factors and propensity for metformin use. Among 14 144 recipients with pretransplant type 2 diabetes mellitus, 4.7% filled metformin in the first year post‐transplant; most also received diabetes comedications. Compared to those who received insulin‐based regimens without metformin, patients who received metformin were more likely to be female, have higher estimated glomerular filtration rates, and have undergone transplant more recently. Metformin‐based regimens were associated with significantly lower adjusted all‐cause (aHR 0.180.410.91), malignancy‐related (aHR 0.450.450.99), and infection‐related (aHR 0.120.320.85) mortality, and nonsignificant trends toward lower cardiovascular mortality, graft failure, and acute rejection. No evidence of increased adverse graft or patient outcomes was noted. Use of metformin‐based diabetes treatment regimens may be safe in carefully selected kidney transplant recipients.
871. ALLIUM AMPELOPRASUM var BABINGTONII
Authors: Rix Martyn 
Published: May 2018

SummaryThe bulbil‐bearing and proliferous wild leek, Allium ampeloprasum L. var. babingtonii (Borrer) Syme, from the south‐western coasts of England and Ireland is illustrated. Its history is described and suggestions for its cultivation are given.