bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dispersal of Hydrothermal Vent Larvae at East Pacific Rise 9–10°N Segment
Authors: Xu Guangyu , McGillicuddy D. J. , Mills S. W. , Mullineaux L. S. 
Published: October 2018

AbstractA three‐dimensional, primitive‐equation, ocean circulation model coupled with a Lagrangian particle‐tracking algorithm is used to investigate the dispersal and settlement of planktonic larvae released from discrete hydrothermal habitats on the East Pacific Rise segment at 9–10°N. Model outputs show that mean circulation is anticyclonic around the ridge segment, which consists of a northward flow along the western flank and a southward flow along the eastern flank. Those flank jets are dispersal expressways for the along‐ridge larval transport and strongly affect its overall direction and spatial‐temporal variations. It is evident from model results that the transform faults bounding the ridge segment and off axis topography (the Lamont Seamount Chain) act as topographic barriers to larval dispersal in the along‐ridge direction. Furthermore, the presence of an overlapping spreading center and an adjacent local topographic high impedes the southward along‐ridge larval transport. The model results suggest that larval recolonization within ridge‐crest habitats is enhanced by the anticyclonic circulation around the ridge segment, and the overall recolonization rate is higher for larvae having a short precompetency period and an altitude above the bottom sufficient to avoid influence by the near‐bottom currents Surprisingly, for larvae having a long precompetency period (>10 days), the prolonged travel time allowed some of those larvae to return to their natal vent clusters, which results in an unexpected increase in connectivity among natal and neighboring sites. Overall, model‐based predictions of connectivity are highly sensitive to the larval precompetency period and vertical position in the water column.
Distribution and Diagenesis of Phosphorus in the Deep‐Sea Sediments of the Central Indian Basin
Authors: Linsy P. , Nagender Nath B. , Mascarenhas‐Pereira M. B. L. , Chauhan Teena , Sebastian Tyson , Babu C. P. , Kurian Siby , Miriyala Pavan , Kazip Armoury , Borole D. V. , Khadge N. H. 
Published: October 2018

AbstractA regional solid‐phase phosphorus (P) speciation study in the Central Indian Basin (CIB) was carried out to elucidate the spatial distribution of sedimentary P species and P diagenesis in an oligotrophic setting. The results show that P enrichment is in the order of biogenic (Pbio) > authigenic (Pauth) > iron bound (PFe) > detrital (Pdet) > organic (Porg) P. The higher concentrations of Pbio are found in siliceous oozes, which are attributed to high biological productivity in the overlying waters compared to pelagic clay region. High Pauth and Pdet contents with low molar Corg/Preact ratios in the pelagic/red clays indicate the deposition of calcium fluorapatite and refractory material from the atmospheric input. The oxygenated bottom water promotes adsorption of P onto iron oxyhydroxides making the PFe an important sink. Remobilization of P within the sediments is limited because of well‐oxygenated conditions and an efficient adsorption by iron oxyhydroxides and clay‐sized sediments. A twofold increase in Ptotal and P‐species is observed in hydrothermally altered, ferruginous sediments from a seamount flank suggesting an important role of hydrothermal processes in P cycling. The calculated P accumulation rate in the present study ranges between 0.6 and 11.7 μmol·cm−2·kyr−1. The burial flux of P for the entire CIB (5.7 × 106 km2) is 0.01 × 1010 mol P per year which accounts for 0.05% of the global flux. The benthic P fluxes from the seawater to the sediments in the area range between 0.0093 and 0.133 μmol·cm−2·kyr−1 indicating that the CIB sediments are an important sink for P.
Variability of Martian Turbopause Altitudes
Authors: Slipski M. , Jakosky B. M. , Benna M. , Elrod M. , Mahaffy P. , Kass D. , Stone S. , Yelle R. 
Published: October 2018

AbstractThe turbopause and homopause represent the transition from strong turbulence and mixing in the middle atmosphere to a molecular‐diffusion‐dominated region in the upper atmosphere. We use neutral densities measured by the Neutral Gas and Ion Mass Spectrometer on the Mars Atmospheric and Volatile EvolutioN spacecraft from February 2015 to October 2016 to investigate the temperature structure and fluctuations of the Martian upper atmosphere. We compare those with temperature measurements of the lower atmosphere from the Mars Reconnaissance Orbiter's Mars Climate Sounder. At the lowest Mars Atmospheric and Volatile EvolutioN altitudes we often observe a statically stable region where waves propagate freely. In contrast, regions from about 20 km up to at least 70 km are reduced in stability where waves are expected to dissipate readily due to breaking/saturation. We derive homopause altitudes from Neutral Gas and Ion Mass Spectrometer N2 and Ar densities and find that it varies between 60 and 140 km. From the standard deviations in monthly averaged temperature profiles, we determine the wave turbopause altitude where applicable and find that these altitudes agree with the homopause altitudes. We show that the homopause variability is driven by order of magnitude changes in CO2 densities, which drastically affect the altitude at which the eddy diffusion is equal to the molecular diffusion. These variations are observed as a function of local time, latitude, and season. That the turbopause/homopause does not track a fixed density level means that the eddy diffusion coefficient at the turbopause can vary significantly, suggesting differences in the dominant breaking waves and tidal modes.
High‐Resolution Land Surface Modeling of Hydrological Changes Over the Sanjiangyuan Region in the Eastern Tibetan Plateau: 1. Model Development and Evaluation
Authors: Yuan Xing , Ji Peng , Wang Linying , Liang Xin‐Zhong , Yang Kun , Ye Aizhong , Su Zhongbo , Wen Jun 
Published: October 2018

AbstractHigh‐resolution modeling became popular in recent years due to the availability of multisource observations, advances in understanding fine‐scale processes, and improvements in computing facilities. However, modeling of hydrological changes over mountainous regions is still a great challenge due to the sensitivity of highland water cycle to global warming, tightly coupled hydrothermal processes, and limited observations. Here we show a successful high‐resolution (3 km) land surface modeling over the Sanjiangyuan region located in the eastern Tibetan plateau, which is the headwater of three major Asian rivers. By developing a new version of a Conjunctive Surface‐Subsurface Process model named as CSSPv2, we increased Nash‐Sutcliffe efficiency by 62–130% for streamflow simulations due to the introduction of a storage‐based runoff generation scheme, reduced errors by up to 31% for soil moisture modeling after considering the effect of soil organic matter on porosity and hydraulic conductivity. Compared with ERA‐Interim and Global Land Data Assimilation System version 1.0 reanalysis products, CSSPv2 reduced errors by up to 30%, 69%, 92%, and 40% for soil moisture, soil temperature, evapotranspiration, and terrestrial water storage change, respectively, as evaluated against in situ and satellite observations. Moreover, CSSPv2 well captured the elevation‐dependent ground temperature warming trends and the decreased frozen dates during 1979–2014, and significant increasing trends (p < 0.05) in evapotranspiration and terrestrial water storage during 1982–2011 and 2003–2014 respectively, while ERA‐Interim and Global Land Data Assimilation System version 1.0 showed no trends or even negative trends. This study implies the necessity of developing high‐resolution land surface models in realistically representing hydrological changes over highland areas that are sentinels to climate change.
Do borderline personality disorder and attention-deficit/hyperactivity disorder co-aggregate in families? A population-based study of 2 million Swedes
Authors: Kuja-Halkola Ralf , Lind Juto Kristina , Skoglund Charlotte , Rück Christian , Mataix-Cols David , Pérez-Vigil Ana , Larsson Johan , Hellner Clara , Långström Niklas , Petrovic Predrag , Lichtenstein Paul , Larsson Henrik 
Published: October 2018

AbstractLarge-scale family studies on the co-occurrence of attention-deficit/hyperactivity disorder (ADHD) and borderline personality disorder (BPD) are lacking. Thus, we aimed to estimate the co-occurrence and familial co-aggregation of clinically ascertained ADHD and BPD diagnoses using the entire Swedish population. In a register-based cohort design we included individuals born in Sweden 1979–2001, and identified their diagnoses during 1997–2013; in total, 2,113,902 individuals were included in the analyses. We obtained clinical diagnoses of ADHD and BPD from inpatient and outpatient care. Individuals with an ADHD diagnosis had an adjusted (for birth year, sex, and birth order) odds ratio (aOR) of 19.4 (95% confidence interval [95% CI] = 18.6–20.4) of also having a BPD diagnosis, compared to individuals not diagnosed with ADHD. Having a sibling with ADHD also increased the risk for BPD (monozygotic twins, aOR = 11.2, 95% CI = 3.0–42.2; full siblings, aOR = 2.8, 95% CI = 2.6–3.1; maternal half-siblings, aOR = 1.4, 95% CI = 1.2–1.7; paternal half-siblings, aOR = 1.5, 95% CI = 1.3–1.7). Cousins also had an increased risk. The strength of the association between ADHD and BPD was similar in females and males, and full siblings showed similar increased risks regardless of sex. Among both males and females, ADHD and BPD co-occur within individuals and co-aggregate in relatives; the pattern suggests shared genetic factors and no robust evidence for etiologic sex differences was found. Clinicians should be aware of increased risks for BPD in individuals with ADHD and their relatives, and vice versa.
A phylogenomic and ecological analysis of the globally abundant Marine Group II archaea (Ca. Poseidoniales ord. nov.)
Authors: Rinke Christian , Rubino Francesco , Messer Lauren F , Youssef Noha , Parks Donovan H , Chuvochina Maria , Brown Mark , Jeffries Thomas , Tyson Gene W , Seymour Justin R , Hugenholtz Philip 
Published: October 2018

AbstractMarine Group II (MGII) archaea represent the most abundant planktonic archaeal group in ocean surface waters, but our understanding of the group has been limited by a lack of cultured representatives and few sequenced genomes. Here, we conducted a comparative phylogenomic analysis of 270 recently available MGII metagenome-assembled genomes (MAGs) to investigate their evolution and ecology. Based on a rank-normalised genome phylogeny, we propose that MGII is an order-level lineage for which we propose the name Candidatus Poseidoniales (after Gr. n. Poseidon, God of the sea), comprising the families Candidatus Poseidonaceae fam. nov. (formerly subgroup MGIIa) and Candidatus Thalassarchaeaceae fam. nov. (formerly subgroup MGIIb). Within these families, 21 genera could be resolved, many of which had distinct biogeographic ranges and inferred nutrient preferences. Phylogenetic analyses of key metabolic functions suggest that the ancestor of Ca. Poseidoniales was a surface water-dwelling photoheterotroph that evolved to occupy multiple related ecological niches based primarily on spectral tuning of proteorhodopsin genes. Interestingly, this adaptation appears to involve an overwrite mechanism whereby an existing single copy of the proteorhodopsin gene is replaced by a horizontally transferred copy, which in many instances should allow an abrupt change in light absorption capacity. Phototrophy was lost entirely from five Ca. Poseidoniales genera coinciding with their adaptation to deeper aphotic waters. We also report the first instances of nitrate reductase in two genera acquired via horizontal gene transfer (HGT), which was a potential adaptation to oxygen limitation. Additional metabolic traits differentiating families and genera include flagellar-based adhesion, transporters, and sugar, amino acid, and peptide degradation. Our results suggest that HGT has shaped the evolution of Ca. Poseidoniales to occupy a variety of ecological niches and to become the most successful archaeal lineage in ocean surface waters.
Novel dihydroartemisinin derivative DHA-37 induces autophagic cell death through upregulation of HMGB1 in A549 cells
Authors: Liu Xiufeng , Wu Juanjuan , Fan Menglin , Shen Chen , Dai Wenling , Bao Yini , Liu Ji-Hua , Yu Bo-Yang 
Published: October 2018

AbstractDihydroartemisinin (DHA) and its analogs are reported to possess selective anticancer activity. Here, we reported a novel DHA derivative DHA-37 that exhibited more potent anticancer activity on the cells tested. Distinct from DHA-induced apoptosis, DHA-37 triggered excessive autophagic cell death, and became the main contributor to DHA-37-induced A549 cell death. Incubation of the cells with DHA-37 but not DHA produced increased dots distribution of GFP-LC3 and expression ratio of LC3-II/LC3-I, and enhanced the formation of autophagic vacuoles as revealed by TEM. Treatment with the autophagy inhibitor 3-MA, LY294002, or chloroquine could reverse DHA-37-induced cell death. In addition, DHA-37-induced cell death was associated significantly with the increased expression of HMGB1, and knockdown of HMGB1 could reverse DHA-37-induced cell death. More importantly, the elevated HMGB1 expression induced autophagy through the activation of the MAPK signal but not PI3K-AKT–mTOR pathway. In addition, DHA-37 also showed a wonderful performance in A549 xenograft mice model. These findings suggest that HMGB1 as a target candidate for apoptosis-resistant cancer treatment and artemisinin-based drugs could be used in inducing autophagic cell death.
Plasminogen activation is required for the development of radiation-induced dermatitis
Authors: Fallah Mahsa , Shen Yue , Brodén Jessica , Bäckman Assar , Lundskog Bertil , Johansson Michael , Blomquist Michael , Liu Kui , Wilczynska Malgorzata , Ny Tor 
Published: October 2018

AbstractSkin damage caused by radiation therapy (radiodermatitis) is a severe side effect of radiotherapy in cancer patients, and there is currently a lack of effective strategies to prevent or treat such skin damage. In this work, we show with several lines of evidence that plasminogen, a pro-inflammatory factor, is key for the development of radiodermatitis. After skin irradiation in wild-type (plg+/+) mice, the plasminogen level increased in the irradiated area, leading to severe skin damage such as ulcer formation. However, plasminogen-deficient (plg−/−) mice and mice lacking plasminogen activators were mostly resistant to radiodermatitis. Moreover, treatment with a plasminogen inhibitor, tranexamic acid, decreased radiodermatitis in plg+/+ mice and prevented radiodermatitis in plg+/− mice. Together with studies at the molecular level, we report that plasmin is required for the induction of inflammation after irradiation that leads to radiodermatitis, and we propose that inhibition of plasminogen activation can be a novel treatment strategy to reduce and prevent the occurrence of radiodermatitis in patients.
Oleanolic acid enhances neural stem cell migration, proliferation, and differentiation in vitro by inhibiting GSK3β activity
Authors: Zhang Shi Qing , Lin Kai Li , Law Cheuk Yu , Liu Bin , Fu Xiu Qiong , Tse Wing Sze , Wong Samantha Sze Man , Sze Stephen Cho Wing , Yung Ken Kin Lam 
Published: October 2018

AbstractOleanolic acid (OA), one of the bioactive ingredients in ginseng, has been reported to have neuroprotective activities. However, the effects and its mechanism on neural stem cell (NSC) induction are not entirely clear. In the present study, we investigated the effects of OA on promoting the migration, proliferation, and differentiation of neural stem cells (NSCs). Migration and proliferation were investigated by using neural-specific markers, neurosphere assay, and Cell Counting Kit-8, respectively. We found OA remarkably promoted neural migration and proliferation of NSCs in a time- and dose-dependent manner. Differentiation was analyzed by western blotting and immunofluorescence staining, which found MAP2 expression was remarkably increased, whereas Nestin was dramatically decreased. In addition, OA increased phosphorylation of GSK3β at Ser9 and expression of active forms of β-catenin. Furthermore, NSCs with constitutively active GSK3β (S9A) significantly suppressed the OA-induced proliferation and neural differentiation. These results showed that OA could stimulate NSC proliferation and neural differentiation in vitro via suppressing the activity of GSK3β. Our findings may have significant implications for the treatment of neurodegenerative diseases.
Mycobacterial DnaB helicase intein as oxidative stress sensor
Authors: Kelley Danielle S. , Lennon Christopher W. , Li Zhong , Miller Michael R. , Banavali Nilesh K. , Li Hongmin , Belfort Marlene 
Published: October 2018

AbstractInteins are widespread self-splicing protein elements emerging as potential post-translational environmental sensors. Here, we describe two inteins within one protein, the Mycobacterium smegmatis replicative helicase DnaB. These inteins, DnaBi1 and DnaBi2, have homology to inteins in pathogens, splice with vastly varied rates, and are differentially responsive to environmental stressors. Whereas DnaBi1 splicing is reversibly inhibited by oxidative and nitrosative insults, DnaBi2 is not. Using a reporter that measures splicing in a native intein-containing organism and western blotting, we show that H2O2 inhibits DnaBi1 splicing in M. smegmatis. Intriguingly, upon oxidation, the catalytic cysteine of DnaBi1 forms an intramolecular disulfide bond. We report a crystal structure of the class 3 DnaBi1 intein at 1.95 Å, supporting our findings and providing insight into this splicing mechanism. We propose that this cysteine toggle allows DnaBi1 to sense stress, pausing replication to maintain genome integrity, and then allowing splicing immediately when permissive conditions return.
Master clinical medical knowledge at certificated-doctor-level with deep learning model
Authors: Wu Ji , Liu Xien , Zhang Xiao , He Zhiyang , Lv Ping 
Published: October 2018

AbstractMastering of medical knowledge to human is a lengthy process that typically involves several years of school study and residency training. Recently, deep learning algorithms have shown potential in solving medical problems. Here we demonstrate mastering clinical medical knowledge at certificated-doctor-level via a deep learning framework Med3R, which utilizes a human-like learning and reasoning process. Med3R becomes the first AI system that has successfully passed the written test of National Medical Licensing Examination in China 2017 with 456 scores, surpassing 96.3% human examinees. Med3R is further applied for providing aided clinical diagnosis service based on real electronic medical records. Compared to human experts and competitive baselines, our system can provide more accurate and consistent clinical diagnosis results. Med3R provides a potential possibility to alleviate the severe shortage of qualified doctors in countries and small cities of China by providing computer-aided medical care and health services for patients.
Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes
Authors: Zhu Xiang , Stephens Matthew 
Published: October 2018

AbstractGenome-wide association studies (GWAS) aim to identify genetic factors associated with phenotypes. Standard analyses test variants for associations individually. However, variant-level associations are hard to identify and can be difficult to interpret biologically. Enrichment analyses help address both problems by targeting sets of biologically related variants. Here we introduce a new model-based enrichment method that requires only GWAS summary statistics. Applying this method to interrogate 4,026 gene sets in 31 human phenotypes identifies many previously-unreported enrichments, including enrichments of endochondral ossification pathway for height, NFAT-dependent transcription pathway for rheumatoid arthritis, brain-related genes for coronary artery disease, and liver-related genes for Alzheimer’s disease. A key feature of our method is that inferred enrichments automatically help identify new trait-associated genes. For example, accounting for enrichment in lipid transport genes highlights association between MTTP and low-density lipoprotein levels, whereas conventional analyses of the same data found no significant variants near this gene.
Self-powered H2 production with bifunctional hydrazine as sole consumable
Authors: Liu Xijun , He Jia , Zhao Shunzheng , Liu Yunpeng , Zhao Zhe , Luo Jun , Hu Guangzhi , Sun Xiaoming , Ding Yi 
Published: October 2018

AbstractSplitting hydrazine into H2 and N2 by electro-catalyzing hydrogen evolution and hydrazine oxidation reactions is promising for replacing fossil energy with H2. However, current hydrazine splitting is achieved using external powers to drive the two reactions, which is inapplicable to outdoor use. Here, Fe-doped CoS2 nanosheets are developed as a bifunctional electrocatalyst for the two reactions, by which direct hydrazine fuel cells and overall-hydrazine-splitting units are realized and integrated to form a self-powered H2 production system. Without external powers, this system employs hydrazine bifunctionally as the fuel of direct hydrazine fuel cell and the splitting target, namely a sole consumable, and exhibits an H2 evolution rate of 9.95 mmol h−1, a 98% Faradaic efficiency and a 20-h stability, all comparable to the best reported for self-powered water splitting. These performances are due to that Fe doping decreases the free-energy changes of H adsorption and adsorbed NH2NH2 dehydrogenation on CoS2.
Composite fermion liquid to Wigner solid transition in the lowest Landau level of zinc oxide
Authors: Maryenko D. , McCollam A. , Falson J. , Kozuka Y. , Bruin J. , Zeitler U. , Kawasaki M. 
Published: October 2018

AbstractInteractions between the constituents of a condensed matter system can drive it through a plethora of different phases due to many-body effects. A prominent platform for it is a dilute two-dimensional electron system in a magnetic field, which evolves intricately through various gaseous, liquid and solid phases governed by Coulomb interaction. Here we report on the experimental observation of a phase transition between the composite fermion liquid and adjacent magnetic field induced phase with a character of Wigner solid. The experiments are performed in the lowest Landau level of a MgZnO/ZnO two-dimensional electron system with attributes of both a liquid and a solid. An in-plane magnetic field component applied on top of the perpendicular magnetic field extends the Wigner-like phase further into the composite fermion liquid phase region. Our observations indicate the direct competition between a composite fermion liquid and a Wigner solid formed either by electrons or composite fermions.
Closing the gender gap in competitiveness through priming
Authors: Balafoutas Loukas , Fornwagner Helena , Sutter Matthias 
Published: October 2018

AbstractMen have been observed to have a greater willingness to compete compared to women, and it is possible that this contributes to gender differences in wages and career advancement. Policy interventions such as quotas are sometimes used to remedy this but these may cause unintended side-effects. Here, we present experimental evidence that a simple and practically costless tool—priming subjects with power—can close the gender gap in competitiveness. While in a neutral as well as in a low-power priming situation men are much more likely than women to choose competition, this gap vanishes when subjects are primed with a high-power situation. We show that priming with high power makes competition entry decisions more realistic and also that it reduces the level of risk tolerance among male participants, which can help explain why it leads to a closing down of the gender gap in competitiveness.