bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subtle Molecular Engineering around Flavin core for Stimuli‐Responsive Solid‐State Luminophore
Authors: Gopal Agrawal Harsha , Dubey Adamya , Mondal Dipayan , Kumar Mishra Ashutosh 
Published: December 2024

AbstractThe present manuscript discusses the design, synthesis, and stimuli‐responsive solid‐state properties of two novel flavin analogues, Phenyl Flavin (PhFl) and Pyridinyl Flavin (PyFl), featuring covalently linked phenyl and pyridinyl rings to isoalloxazine. Stimuli‐responsive properties of PhFl and PyFl were examined, where PyFl displayed more pronounced and reversible emissive behavior in the solid state in response to external stimuli. To elucidate the mechanism underlying the mode for switching behavior, single crystal‐ and powder‐X‐ray diffraction, as well as differential scanning calorimetry studies, were performed. Furthermore, a simple dip‐in method was used to demonstrate its usage as ink free rewritable material.
A New Synthetic Analogue Of The Burckhardtite Mineral, Pb2TeGa[AlSi3O8]O6: Synthesis, Structure, And Properties
Authors: Malik Diksha , Natarajan Srinivasan 
Published: December 2024

AbstractThe mineral, Burckhardtite, Pb2TeFe[AlSi3O8]O6, is synthesized and characterized. A new analogue, Pb2TeGa[AlSi3O8]O6, is successfully prepared for the first time under laboratory conditions. The substitution of Ga3+ by Ti0.5M0.5 (M=Co2+, Ni2+) results in new compounds with the Burckhardtite mineral structure. The transition metal‐containing compounds exhibit interesting new colors, partly resulting from d‐d transitions and metal‐to‐metal charge transfer (MMCT) transition. The Ga compound shows a deep UV cut‐off (~86 %), which is one of the better known values of deep UV cut‐off compounds. The compounds exhibit good dielectric behavior with low dielectric loss. The Eu3+ ‐ substituted samples show deep red emission with a long lifetime of ~0.89 ms. The magnetic behavior of the transition metal containing compounds indicates anti‐ferromagnetic interactions. The successful synthesis of the naturally occurring mineral along with newer analogues with interesting properties suggests that it is profitable to investigate compounds of mineral origin.
Sustainable strategy of biowaste into graphene‐based zinc oxide nanocomposite using green nanotechnology for topical applications
Authors: M Chamundeeswari , KR Preethy 
Published: December 2024

AbstractMetal‐based nanoparticles have been extensively researched for their distinctive characteristics. Among them, zinc oxide nanoparticles have numerous applications in the field of biomedicine. The phytoextract of Ixora coccinea flowers was used in the synthesis of ZnO nanoparticles replacing the use of harmful reducing chemicals. In the current research, the carbonaceous material from biowaste of Setaria italica was used to synthesize graphene oxide (GO) by Improved Hummer's method. The synthesized GO was converted to reduced GO via green nanotechnology using phytoextract of Prosopis juliflora. The synthesis of reduced Graphene Oxide ‐ Zinc Oxide Nanocomposite (rGO)–ZnO nanocomposite involves a simple, economical one‐step magnetic stirring method. UV–visible spectroscopy was used to characterize the synthesized materials, with the maximal absorbance range for ZInc Oxide (ZnO) being 384 nm and for rGO–ZnO composite at 243 and 366 nm, respectively. The x‐ray diffraction (XRD) revealed 2θ peaks for ZnO at 31.54°, 34.22°, and 36.08°. For reduced Graphene Oxide (rGO) in rGO–ZnO composite, the XRD revealed 2θ peaks at 21.25°, 21.56°, 23.14°, and for ZnO at 31.74°, 33.24°, 34.29°, 36.23°. The FT‐IR demonstrated the vibrational modes of functional groups: –OH stretching, symmetric and antisymmetric –CH2 stretching, C = C stretching, and C–O stretching. The elemental composition of samples has been analyzed using Energy Dispersive x‐ray spectroscop (EDX), and the high percentage of zinc in the composite shows a good loading rate of ZnO on the rGO's surface. By morphological investigation, monolayer sheet structures of rGO loaded with clusters of ZnO are clearly demonstrated. Positive results from therapeutic assays and biocompatibility were found with reduced hemolysis and good anticoagulation abilities proved with statistical approach. Our research is distinctive because a realistic formulation of an rGO—ZnO skin care cream with enhanced therapeutic properties, such as effective stability, spreadability, and significant moisture retention, can be recommended.
When Should Sustainability Have A C‐Suite Seat? An Empirical Study on the Environmental and Organizational Correlates of Chief Sustainability Officer Positions
Authors: Liu Yu 
Published: December 2024

ABSTRACTThis study follows a theory‐based approach to examine both environmental and organizational factors related to chief sustainability officer (CSO) positions. We argue that the creation of CSO positions is driven by a combination of external and internal factors, and yet to date there has been limited research that integrates both perspectives to examine the presence and authority of CSO roles. Using a sample of S&P 500 firms, we found that the presence of CSO positions was related both externally to environmental conditions such as regulatory pressures and industry dynamism, and internally to organizational choices such as board‐level sustainability committees and internationalization. We also found that CSO authority was positively related to the organizational factors but not the environmental variables. This study complements existing CSO research by examining the factors linked to CSO presence and authority. The findings may assist researchers and practitioners in better understanding the effectiveness of CSO roles.
Serial Dilation and Intentional Fracturing of Stents in Congenital Heart Disease—Benchside Tests and Initial Clinical Results
Authors: Gendera K. , Bambul Heck P. , Eicken A. , Tanase D. , Ewert P. , von Stumm M. , Georgiev S. 
Published: December 2024

ABSTRACTBackgroundThere is some reluctance to implant stents in small children due to concerns regarding outgrowing the maximal stent diameter during follow‐up.AimEvaluation of a treatment strategy on the bench side, including intentional stent fracturing, and description of our initial clinical experience.MethodsA series of benchside tests was performed with small stents, in which the stents were dilated above the rated diameters until they ultimately fractured. The diameters and pressures needed to fracture these stents were documented. This approach of intentional stent fracturing was used to treat the first series of patients.ResultsBenchside testing of coronary stents (Coroflex blue, Onyx, and Bentley coronary) and the different‐sized Cook Formula stents confirmed that all these can be fractured intentionally. An important step to prevent the development of a “napkin ring” was to implant a second larger stent before dilatation with ultra‐high pressure balloons (fracturing procedure). In 17 patients, previously implanted stents were dilated serially and ultimately fractured. The stents had been implanted in branch pulmonary arteries (n = 9), in the right ventricular outflow tract (n = 3), and in the aortic isthmus (n = 5). After dilation up to the fracturing diameter known from the benchside tests, a second larger stent was implanted and the initial stent was fractured with ultra‐high‐pressure dilatation. Fracturing of the stent was possible in all patients. No serious complications were noted.ConclusionSerial dilatation and intentional fracturing of stents are feasible, do not increase the risk for complications, and may play an important role in the management of growing children with congenital heart defects.
Emerging Educational and Networking Platforms in Interventional Cardiology: Expanding Beyond Traditional Social Media
Authors: Bharadwaj Aditya S. , Cader F. Aaysha , Goldsweig Andrew M. , Kini Annapoorna , Sharma Samin , Gluckman Ty J. , O'Leary Jared , Cohen David , Cigarroa Joaquin E. , Alasnag Mirvat 
Published: December 2024

ABSTRACTWith ubiquitous use of smartphones and other Internet‐enabled devices, clinicians have access to a plethora of multimedia platforms that enable them to network, share educational content, and learn. Several platforms also enable resources that support clinical decision making. Traditional social media has been used extensively by cardiologists for several years and now extends to the entire care team including trainees, advanced practitioners, nurses and technologists. Numerous challenges include concerns about patient privacy and security, lack of peer‐review and organization, and chances of propagating misinformation. More recently, newer networking platforms have emerged within cardiology to overcome several of the limitations of traditional social media. Additionally, mobile applications have emerged as an educational tool that provides clinicians with easy access to the latest information including guidelines, consensus documents, risk estimators and treatment algorithms. These point‐of‐care learning and decision‐making tools are especially relevant and impactful in a procedural field like interventional cardiology. While professional societies are major drivers of these emerging platforms, there are also other stakeholders including educational institutions and the medical device industry. In this review article, we examine the role of traditional social media and describe newer networking platforms as well as mobile applications applicable to interventional cardiology with a discussion about their relative advantages and disadvantages.
Development of Pseudosacral Cyst Following Surgery for Primary Presacral Neuroendocrine Tumors With Liver Metastasis: A Case Report
Authors: Jian Li , Wang Youheng , Hao Yu , Zhao Ding , Songlin Wan , Qun Qian , Daojiang Li 
Published: December 2024

ABSTRACTPresacral neuroendocrine tumor (PSNET) is a rare disease that currently lacks a standardized treatment approach. In this report, we present a unique case of PSNET with liver metastasis that progressed into a pseudosacral cyst following complete surgical resection and sulfatinib treatment with radiofrequency ablation. Before undergoing surgical treatment for presacral neuroendocrinology, it is important to consider the potential risks of poor healing of the presacral incision and formation of pseudocysts. These complications may be caused by various factors, including the procedure itself and the use of targeted drugs.
Nanohybrids of 2D Black Phosphorus with Phthalocyanines: Role of Interfacial Interactions in Heterostructure Development
Authors: Scittarelli Doriana , Coiai Serena , Cicogna Francesca , Legnaioli Stefano , Dell'Angela Martina , Verdini Alberto , Costantini Roberto , Serrano‐Ruiz Manuel , Passaglia Elisa , Caporali Maria 
Published: December 2024

AbstractNew 2D black phosphorus (bP)–phthalocyanine (Pc) nanohybrids have been synthesized by liquid phase exfoliation of black phosphorus crystals in the presence of two organic dyes: phthalocyanine (Pc) and manganese phthalocyanine (MnPc). The key role of the metal cation in the interfacial interaction between the organic dye and bP nanosheets was demonstrated by X‐ray absorption spectroscopy and associated with an electron transfer between the metal cation Mn2+ and bP nanosheets, which resembles a coordinative chemical bond. On the other hand, the interaction between bP nanosheets and pure phthalocyanine is governed by van der Waals forces. The fluorescence of both hybrids is significantly reduced indicating effective separation of the photoinduced charge, implying the formation of a heterojunction between the organic molecules and the bP nanosheets. These findings provide important insights into the interfacial interactions in bP‐Pc nanohybrids that are relevant for application in 2D organic/inorganic devices.
Double Strain‐Release (3+3)‐Cycloaddition: Lewis Acid Catalyzed Reaction of Bicyclobutane Carboxylates and Aziridines
Authors: George Malini , Mindner Jasper , Wittmer Silas , Knyazev Daniil A. , Werz Daniel B. 
Published: December 2024

AbstractA (3+3)‐cycloaddition to afford 2‐azabiyclo[3.1.1]heptanes was realized by reacting highly strained aryl bicyclo[1.1.0]butane (BCBs) carboxylates with tosylated aziridines. Under Sc(OTf)3 catalysis the transformation proceeded smoothly under mild conditions to the corresponding bicyclic products bearing at the bridgeheads of the embedded four‐membered ring aryl and ester moieties, respectively. This reaction is a rare example of a cycloaddition of two highly strained ring systems under Lewis acid catalysis. Mechanistic experiments provided insights into the reaction mechanism.
Extracellular vesicles derived from creeping fat stem cells promote lymphatic function and restrain inflammation of Crohn's disease
Authors: Shu Weigang , Wang Yongheng , Chen Mengfan , Zhu Xiaoli , Wang Fangtao , Chen Chunqiu , Du Peng , Bartolomucci Alexandra , Su Xin , Wang Xiaolei 
Published: December 2024

AbstractBackgroundCrohn's disease (CD) is a chronic inflammatory disease in the intestinal tract. Mesenteric fat wrapping and thickening, or creeping fat (CrF), is a typical characteristic of CD and it involves lymphangiogenesis and altered lymphatic function. By releasing extracellular vesicles (EVs), adipose tissue‐derived stem cells (ADSCs) can regulate their adjacent cells. However, the regulating roles of ADSC‐EVs in CrF (CrF‐EVs) in CD, especially in modulating lymphatic function and mitigating the progression of mesenteritis and colitis, remains elusive.MethodsTo evaluate the regulative roles of CrF‐EVs on lymphatic functions, in vitro assays were performed using human lymphatic endothelial cells (HLECs). Next, Interleukin 10 knock‐out (Il‐10−/−) mice were used to assess the biological functions of CrF‐EVs in spontaneous mesenteritis and colitis. Moreover, tissue and serum from various cohorts of CD patients were used to determine the prognostic value of miR‐132‐3p.ResultsCrF‐EVs significantly attenuated spontaneous mesenteritis and colitis in Il‐10−/− mice via promoting lymphangiogenesis and lymphatic drainage. Using high‐throughput sequencing, we demonstrated that CrF‐EVs significantly increased HLEC proliferation, migration, tube formation and CCL‐21 production in a miR‐132‐3p/RASA1/ERK1/2 axis‐dependent manner. Accordingly, upregulated miR‐132‐3p was observed in patient CrF, positively correlated with lymphangiogenesis while negatively correlated with inflammatory factors (tumour necrosis factor‐α and IL‐6) level. Moreover, serum miR‐132‐3p demonstrated a positive correlation with disease activity.ConclusionsEVs derived from CrF ADSCs, containing elevated levels of miR‐132‐3p, could promote lymphatic function and restrain inflammation of CD. Our results provide a novel insight into the role of mesenteric lymphatics in CD progression and reveal a new potential therapeutic.Key points
Extracellular vesicles (EVs) of creeping fat (CrF) derived adipose stem cells effectively attenuate chronic mesenteritis and colitis in Crohn's disease (CD).
The lymphatic vessels play an important role in disease development of CD and their functions are improved by CrF‐EV‐miR‐132‐3p through RASA1/ERK1/2 signaling.
MiR‐132‐3p expression is upregulated in CrF and serum of CD patients, and tightly linked with inflammation and disease activity.
Elucidating epigenetic landscape of gastric premalignant lesions through genome‐wide mapping of 5‐hydroxymethylcytosines: A 12‐year median follow‐up study
Authors: Luo Zhongguang , Li Wenshuai , Zheng Wanwei , Shi Yixiang , Ye Maolin , Guo Xiangyu , Fu Kaiyi , Yan Changsheng , Wang Bowen , Lv Bin , Mo Shaocong , Zhang Hongyang , Zhang Jun , He Chuan , Luo Feifei , Zhang Wei , Liu Jie 
Published: December 2024

AbstractBackgroundEpigenetic modifications are crucial in tumourigenesis, yet the changes in novel epigenetic regulators like 5‐hydroxymethylcytosines (5hmC) during the evolution of gastric premalignant lesions remain poorly understood. This study aims to investigate the implications of 5hmC in the progression from gastric premalignant lesions to gastric adenocarcinoma (GAC).MethodsTo our knowledge, we conducted the largest and longest longitudinal study of a Chinese population with gastric precursor lesions, involving 29,176 patients with gastritis who underwent gastroscopy and biopsy between 2001 and 2015, with follow‐up until 1 August, 2022. The median follow‐up time was 12.2 years, and the overall GAC incidence rate was 0.82%. Genome‐wide mapping of 5hmC in gastric premalignant lesions from a subset of individuals was performed using the 5hmC‐Seal assay, including 21 samples that progressed to GAC during follow‐up and 48 non‐progressed age‐ and sex‐matched controls.ResultsWe identified 213 differentially modified gene bodies, primarily concentrated in pathways related to cell division, cell cycle, energy metabolism, inflammation and tumourigenesis. An exploratory study was conducted to summarize a 5hmC‐based epigenetic model for predicting cancer progression using multivariable logistic regression and machine learning. The nine‐gene model showed an area under the curve of 87.5% (95% confidence interval: 72%–100%) in the validation samples (one of three), which were set aside before model training.ConclusionsThis study is the first to explore the 5hmC molecular landscape in gastric premalignant lesions, suggesting relevant pathways implicated in their evolution to GAC as well as the feasibility of exploiting genome‐wide 5hmC mapping in assessing the risk of future cancer progression.Key points
A largest longitudinal follow‐up study of gastric precursor lesions in Chinese patients.
Revealing novel 5hmC molecular landscape linked to gastric premalignant lesions.
The feasibility of an innovative 5hmC‐based predictive model for assessing gastric cancer progression risk.
Learning from wildfires: A scalable framework to evaluate treatment effects on burn severity
Authors: Chamberlain Caden P. , Meigs Garrett W. , Churchill Derek J. , Kane Jonathan T. , Sanna Astrid , Begley James S. , Prichard Susan J. , Kennedy Maureen C. , Bienz Craig , Haugo Ryan D. , Smith Annie C. , Kane Van R. , Cansler C. Alina 
Published: December 2024

AbstractInterruption of frequent burning in dry forests across western North America and the continued impacts of anthropogenic climate change have resulted in increases in fire size and severity compared to historical fire regimes. Recent legislation, funding, and planning have emphasized increased implementation of mechanical thinning and prescribed burning treatments to decrease the risk of undesirable ecological and social outcomes due to fire. As wildfires and treatments continue to interact, managers require consistent approaches to evaluate treatment effectiveness at moderating burn severity. In this study, we present a repeatable, remote sensing–based, analytical framework for conducting fire‐scale assessments of treatment effectiveness that informs local management while also supporting cross‐fire comparisons. We demonstrate this framework on the 2021 Bootleg Fire in Oregon and the 2021 Schneider Springs Fire in Washington. Our framework used (1) machine learning to identify key bioclimatic, topographic, and fire weather drivers of burn severity in each fire, (2) standardized workflows to statistically sample untreated control units, and (3) spatial regression modeling to evaluate the effects of treatment type and time since treatment on burn severity. The application of our framework showed that, in both fires, recent prescribed burning treatments were the most effective at reducing burn severity relative to untreated controls. In contrast, thinning‐only treatments only produced low/moderate‐severity effects under the more moderate fire weather conditions in the Schneider Springs Fire. Our framework offers a robust approach for evaluating treatment effects on burn severity at the scale of individual fires, which can be scaled up to assess treatment effectiveness across multiple fires. As climate change brings increased uncertainty to dry forest ecosystems of western North America, our framework can support more strategic management actions to reduce wildfire risk and foster resilience.
Prognostic value of advanced lung cancer inflammation index in heart failure patients: A comprehensive analysis
Authors: Chen Wentao , Zhang Guihua , Lei Qiao , Lu Huixia 
Published: December 2024

AbstractAimsThe prognosis of heart failure (HF) is closely linked to inflammation and nutritional status. The advanced lung cancer inflammation index (ALI) is a composite indicator consisting of several parameters used to assess inflammation and nutritional status. Our study aimed to investigate the prognostic value of ALI in HF patients.MethodsThe data from Study 1, which included 1359 HF patients, were extracted from the National Health and Nutrition Examination Survey (NHANES) database spanning the years 1999 to 2018. Study 2 analysed data from patients with HF who underwent cardiac magnetic resonance imaging examinations from 2020 to 2023. Kaplan–Meier curve analysis, Cox proportional hazard model, time‐dependent receiver operating characteristic (ROC) curve and restricted cubic spline (RCS) were used to evaluate the relationship between ALI and long‐term prognosis of patients with HF in Study 1. Logistic regression analysis was used to evaluate the correlation between ALI and left ventricular reverse remodelling, and RCS was used to determine any dose–response relationship. Spearman correlation was used to evaluate the relationship between ALI and indicators of cardiac structural changes.ResultsStudy 1 found that the average age of the patients was 68 years [inter‐quartile range (IQR) 58–76], the proportion of males was 54.3%, and there were 699 all‐cause mortality and 293 cardiovascular mortality cases. After adjusted by multivariable Cox regression analysis, elevated ALI levels were significantly associated with increased risks of all‐cause [hazard ratio (HR) = 0.58, 95% confidence interval (CI) = 0.42–0.79, P < 0.001] and cardiovascular mortality (HR = 0.61, 95% CI = 0.38–0.97, P = 0.036) in patients with HF. A linear negative correlation was observed between ALI and both all‐cause (P = 0.0011 and P < 0.001, P for nonlinear = 0.3993) and cardiovascular mortality (P = 0.0011, P for nonlinear = 0.5198). Time‐dependent ROC curves showed the predictive value of ALI for all‐cause mortality [area under the curve (AUC) = 0.678 in 3 years, AUC = 0.674 in 5 years and AUC = 0.683 in 10 years] and cardiovascular mortality (AUC = 0.694 in 3 years, AUC = 0.685 in 5 years and AUC = 0.697 in 10 years). Study 2 included 79 patients; the average age of the patients was 44 years (IQR 35–55); and the proportion of males was 74.7%. Adjusted multivariable logistic regression analysis indicated that high ALI levels were associated with left ventricular reverse remodelling (LVRR) in patients with HF following discharge from the hospital [odds ratio (OR) = 3.16, 95% CI = 1.06–10.8, P = 0.049]. Spearman analysis revealed a correlation between ALI and extracellular volume (ECV) (r = −0.25, P = 0.023).ConclusionALI is associated with all‐cause and cardiovascular mortality risk and structural changes in the heart in patients with HF.