bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFEK ANTIOKSIDAN FRAKSI ETIL ASETAT MINUMAN SINOM CAMPURAN JERUK NIPIS DAN MADU (curcuma domestica val-tamarindus indica L.) TERHADAP GULA DARAH TIKUS PUTIH SPRAQUE DAWLEY DIABETES MELITUS
Authors: Wiradnyani N. K. , Arimathea I M. M. 
Published: September 2019

Sinom drinks mixed with lime and honey are made from rhizome of turmeric and young tamarind leaves which are added with lime juice and honey. The aim of the study was to determine the effect of antioxidant compounds of ethyl acetate on sinom drinks mixed with lime juice and honey (SCJM) various doses on fasting blood sugar spraque dawley (SD) white rats diabetes mellitus. Experimental research using RAK, ANOVA analysis with further BNT testing consisted of two stages: 1) test the antioxidant capacity of various solvents of SCJM yielding 29691.1 µg AAEAC / g ingredients namely the highest number of ethyl acetate fractions of n- hexane, chloroform, and water. Phase 2 Ethyl acetate fraction of SCJM was further tested in vivo to SD white rats with diabetes mellitus with various doses, namely: control (-) normal mice, 50, 100, 150, 200 mg/dl BW, control (+) of diabetic rats. The results of the study of the effect of the antioxidant compound SCJM ethyl acetate fraction of various doses significantly affected (p <0.01) in decreasing fasting blood sugar (GDP) white SD diabetes mellitus rats, a dose that can reduce the lowest GDP based on statistical tests is 150 mg/kg BW of rats, 168.4 mg/dl from other doses.
Keywords: ethylacetate, blood sugar, antioxidant, sinom
ISOLASI DAN IDENTIFIKASI GOLONGAN FLAVONOID PADA EKSTRAK ETIL ASETAT DAUN GEDI (Abelmoschus manihot L.)
Authors: Theodora C. T. , Gunawan I W. G. , Swantara I M. D. 
Published: September 2019

The purpose of this experiment was to determine the flavonoid compounds in ethyl acetat extract of gedi leaves (Abelmoschus manihot L.). In this study, the method of extraction was maceration with semipolar solvent (ethyl acetat), flavonoid phytochemical screening, separation and purity test with chromatography and then identification of the compound using FTIR and UV-Vis spectrophotometer with shear reagent method. Analysis of FTIR spectra showed some functional groups such as OH, CH aliphatic, C = O, CO alcohol, C = C aromatic, and CO ether, whereas the analysis with UV-Vis spectra indicated the presence of band I at a wavelength of 409.4 nm and 238.40 nm for band II which is the auron specific wavelength. After the addition of shift reaget, there was a substitutions of OH groups in C-4, C-6 and C-3' and OR at C-4'. The flavonoid compounds contained in ethyl acetate extract of gedi leaf is suggested to be auron, 3',4,6-trihydroxy,4-alkoxy-auron.
Keywords: auron, ethyl acetat extract, flavonoids, gedi leaf, isolation
AKTIVITAS ANTI-RHEUMATOID ARTHRITIS DARI BRAZILIN DAN BRAZILEIN SECARA IN SILICO
Authors: Amarawati G. A. K. , Susanti N. M. P. , Laksmiani N. P. L. 
Published: September 2019

Rheumatoid arthritis is an autoimmune disease that occur by inflammation chronic which persist as a permanent symptom. That inflammatory process caused joint destruction. Production of pro-inflammatory sytokin such as Tumor Necrosis Factor Alpha (TNF-?) stimulate an autoimmunity. Active TNF-? plays a role in the occurrence of chronic inflammation, in which the formation of active TNF-? is regulated by TNF-? Converting Enzyme (TACE). Brazilin and brazilein are known to have anti-inflammatory activity and immunommodulator potentially as anti-rheumatoid arthritis. The purpose of this study were to determine the affinity and mechanisms of brazilin and brazilein against TACE proteins as anti-rheumatoid arthritis perfomed using molecular docking method. The study was conducted exploratively with several steps such as databases preparation of 3D structures brazilin, brazilein, TACE protein, optimization of brazilin and brazilein 3D structures, protein preparation, molecular docking method validation, and docking brazilin and brazilein in these proteins. The docking results are assessed from the binding energy and hydrogen bonds formed between brazilin and brazilein in proteins. The smaller value to the binding energy, will made the bond between brazilin and brazilein with proteins will be stronger and more stable. The results showed that brazilin and brazilein have activities as anti-rheumatoid arthritis because they are able to inhibit TACE proteins with respective bond energy values -7,24 for brazilin and – 7,59 kcal/mol for brazilein. These results show that brazilin and brazilein have the potential to inhibit inflammatory process and joint destruction in rheumatoid arthritis.
Keywords : brazilin, brazilein, in silico, rheumatoid arthritis
MOLECULAR DOCKING AKTIVITAS ANTIKANKER DARI KUERSETIN TERHADAP KANKER PAYUDARA SECARA IN SILICO
Authors: Rastini M. B. O. , Giantari N. K. M. , Adnyani K. D. , Laksmiani N. P. L. 
Published: September 2019

Breast cancer can be initiated by either overexpression of HER-2 protein which can induce dimerization and autophosphorylation so that it triggers the activation of Focal Adhesion Kinase (FAK) resulting in migration and metastasis in breast cancer cells. Quercetin which has another name 3,5,7,3 ', 4'-pentahydroxyflavon with the molecular formula of (C15H10O7) is a flavonoid compound which is very widely found in nature. The purpose of this study was to determine the mechanism of inhibition of overexpression of HER-2 proteins by quercetin compounds by in silico molecular docking. In silico molecular docking was carried out in several stages namely method validation, optimization of 3D quercetin compound structure, docking between quercetin compounds optimized with HER-2 protein based on bond energy parameters the lower the bond energy the stronger and the more stable the bond is. The results of docking expressed by the binding energy of quercetin compounds with HER-2 protein are -8.24 kcal / mol, while the energy of the native ligand bond with HER-2 protein is -10.45 kcal / mol. The bonding energy shows that quercetin compounds have the potential as breast anticancer because they can modulate the overexpression of HER-2 proteins.

Keywords: quercetin, breast cancer, HER-2, in silico
SUPLEMEN EKSTRAK DAUN SIRIH, Piper betle, Lin DALAM MENURUNKAN KADAR MALONDIALDEHID PADA TIKUS WISTAR
Authors: Suirta I W. , Asih I. A. R. A. 
Published: September 2019

Betel leaf extract supplements, Piper betle Lin , was made by extracting maceration of betel leaves with ethanol 96%. Phytochemical screening of betle leaf extract obtained secondary metabolites such as : terpenoids, steroids, phenolics, and saponins . The results of the antioxidant activity test test showed that n-hexane fraction was more reactive as an antioxidant (IC50 26,73 mg/L) than the diethyl ether fraction (IC50 114,54 mg/L). The MDA analysis showed that the betel leaves have a very good ability to reduce MDA levels. The concentration of MDA with addition of allopurinol (as positive control) was 0,41±0,0021?L/mL, while with addition of betel leaves the level was 0,44±0,0021?L/mL. The structure identification obtained active antioxidant compounds such as: cavicol, eugenol, caryophilene and isoeugenol.
Keywords : betel leaf, malondialdehyde, Piper betle, wistar rat
Authors: Sukarmini Nyoman Fabby 
Published: September 2019

Retinopati diabetik (RD) merupakan komplikasi mikrovaskular DM karena adanya kerusakan pembuluh darah retina yang dapat menyebabkan kebutaan permanen. Kontrol glukosa darah yang baik terbukti mengurangi onset dan risiko perkembangan RD. penelitian ini bertujuan untuk mengetahui penggunaan obat antidiabetes pada pasien DM tipe 2 komplikasi RD dan luaran terapi dilihat dari perubahan kadar glukosa darah dan derajat RD pasien. Desain penelitian ini adalah observasional dengan pendekatan retrospektif. Data penelitian diperoleh dari rekam medis pasien DM tipe 2 komplikasi RD periode Januari 2018-Desember 2018 di RSUP Sanglah. Data derajat RD dianalisis secara deskriptif sedangkan perubahan kadar glukosa darah dianalisis secara statisik (paired t-test dan wilcoxon). Pada penelitian ini didapatkan sebanyak 29 pasien yang memenuhi kriteria inklusi dengan penggunaan obat terdiri dari insulin sebanyak 14 pasien (48,3%), OAD (oral antidiabtes drugs) sebanyak 9 pasien (31,0%) dan kombinasi OAD + insulin 6 pasien (20,7%). Rata-rata KGDP pasien menurun signifikan (p<0,05) pada penggunaan OAD, insulin, dan kombinasi OAD + insulin masing-masing sebesar 52,22±20,34; 58,86±19,29 dan 92,83±26,99 mg/dL. Rata-rata KGD2PP pasien menurun signifikan (p<0,05) pada penggunaan OAD dan insulin masing-masing sebesar 69,00±23,22 dan 79,35±31,58 mg/dL, namun pada penggunaan kombinasi OAD + insulin penurunan yang terjadi tidak signifikan (p>0,05) sebesar 67,33±49,55 mg/dL. Rata-rata HbA1c pasien menurun signifikan (p<0,05) pada penggunaan OAD, insulin dan kombinasi OAD + insulin masing-masing sebesar 1,77±0,39; 1,58±0,52 dan 1,60±0,55 %. Peningkatan derajat RD terjadi pada 5 dari 29 (17,24%) pasien.
Kata kunci: Dabetes mellitus tipe 2, Retinopati diabetik, Glukosa darah, OAD, Insulin.
Evaluasi Kualitas Pengungkapan Value at Risk Perbankan Indonesia
Authors: Wibowo Buddi , Fadhila Hasna 
Published: September 2019

Market risk measurement of bank investment portfolios is a still problem not only among practitioners, but also among academicians. The accuracy and quality of market risk disclosures are important issues because transparency of the bank risk level encourages market control in the form of market discipline and it also improve the quality of risk management carried out internally by the bank. This research measures the quality of Value at Risk disclosures carried out by Indonesian banks. The accuracy of Value at Risk in this research is measured from the Value at Risk component which contains information of yield volatility of bank trading treasury activities. To measure Value at Risk disclosure, this research runs various methods of Value at Risk measurement. This research shows Historical Simulation is a Value at Risk method that is most widely used by Indonesia banks. The empirical test results show that the Value at Risk parametric method using asymmetric volatility have better quality than the Value at Risk Historical Simulation method. This research shows that Value at Risk as measured by Historical Simulation method contains the least information of bank trading treasury yields.
Keywords: value at risk; disclosure; market risk; volatility
DISTRIBUSI SPASIAL GASTROPODA Littoraria scabra DI HUTAN MANGROVE PULAU TUNDA SERANG BANTEN, INDONESIA
Authors: Rial Syahrial , Karsim Nanang 
Published: September 2019

Abstrak

Ekosistem pesisir memiliki keanekaragaman hayati yang tinggi, salah satunya adalah ekosistem mangrove. Kajian Distribusi Spasial Gastropoda Littoraria scabra di Hutan Mangrove Pulau Tunda Serang Banten, Indonesia telah dilakukan pada bulan Januari 2014. Hal ini bertujuan untuk memberikan informasi terhadap penyebaran biodiversitas Indonesia khususnya L. scabra. Pengumpulan data gastropoda L. scabra dilakukan dengan membuat transek garis dan plot yang ditarik dari titik acuan (tegakan mangrove terluar) dan tegak lurus garis pantai sampai ke daratan. Transek garis tersebut dibuat petak-petak contoh (plot) dengan ukuran 10 X 10 m2 dan di dalam ukuran 10 x 10 m2 tersebut dibuat plot kecil (sub plot) yang berukuran 1 x 1 m2 sebanyak 5 plot. Hasil penelitian menunjukkan bahwa gastropoda L. scabra terdistribusi merata di hutan mangrove Pulau Tunda Serang Banten. Kemudian komposisi dan kepadatannya lebih tinggi di bagian Timur (284 ind dan 6.31 ind/m2) daripada bagian Selatan (101 ind dan 2.24 ind/m2). Selain itu, hasil penelitian juga memperlihatkan bahwa pola distribusi gastropoda L. scabra di hutan mangrove Pulau Tunda Serang Banten (Timur dan Selatan) tergolong seragam ((I? <1).

Kata kunci: distribusi, gastropoda, Littoraria scabra, mangrove, Pulau Tunda, Indonesia
Pemodelan Distribusi Nitrat di Kawasan Perairan Teluk Benoa
Authors: Raharja I Made Dharma , Hendrawan I Gede , Suteja Yulianto 
Published: September 2019

Teluk Benoa merupakan perairan yang dipengaruhi oleh kondisi lingkungan perairan. Nitrat adalah salah satu parameter perairan yang sangat penting bagi kelangsungan hidup biota di laut. Dari penelitian sebelumnya terkait beban pencemaran nitrat di Teluk Benoa, kondisi nitrat telah melampui kondisi baku mutu yang ditetapkan melalui Peraturan Gubernur Bali Nomor 16 Tahun 2016 tentang Baku Mutu Lingkungan Hidup dan Kriteria Baku Kerusakan Lingkungan Hidup yaitu 0,008 mg/L. Penelitian yang telah dilakukan sebelumnya masih terbatas pada analisis nitrat pada bagian permukaan perairan sehingga dari hal tersebut penting halnya melakukan kajian lebih lanjut terkait kondisi nitrat di kolom perairan Teluk Benoa. Kajian konsentrasi nitrat pada kolom perairan dapat dilakukan dengan observasi secara langsung dilapangan, namun membutuhkan waktu yang cukup lama dan biaya yang tinggi. Sehingga pada penelitian ini digunakan pemodelan numerik. Pemodel numerik yang digunakan dalam penelitian ini adalah Finite Volume Coastal Ocean Model (FVCOM) yang dimodelkan secara 3-D. Dalam analisis distribusi nitrat pada studi ini digunakan persamaan momentum dan persamaan adveksi-difusi. Dari hasil model diketahui pada setiap kondisi pasang surut konsentrasi nitrat pada bagian permukaan perairan Teluk Benoa cenderung tinggi pada daerah bagian barat Teluk Benoa dan timur Teluk Benoa. Sementara pada kolom perairan di Teluk Benoa konsentrasi nitrat cenderung dipengaruhi oleh keadaan elevasi pasang surut. Kondisi nitrat paling tinggi berada pada kondisi surut terendah dan paling rendah berada pada kondisi pasang tertinggi. Konsentrasi nitrat secara vertikal memiliki konsentrasi yang relatif sama.
Case study: methane gas in a groundwater system located in a dolerite ring structure in the Karoo Basin; South Africa
Authors: Hohne D. , de Lange F. , Esterhuyse S. , Sherwood Lollar B. 
Published: September 2019

Abstract
In the past few years numerous assumptions were made on groundwater in the Karoo Basin and related shale gas development, but not many baseline studies were conducted on groundwater and on boreholes where methane currently occurs. This article focuses on one of these boreholes (BHA) in the Ubuntu Local Municipality area, located close to a dolerite ring structure, which is releasing methane gas. Water samples were analysed for macro and trace elements, environmental isotopes and methane concentrations. Chemical analyses results indicate that groundwater at this borehole may be a mixture between deep groundwater, shallow groundwater and meteoric water. A rise in the groundwater level and subsequent flowing artesian conditions that was observed, support the theory that mixing between deeper groundwater from the Ecca Group and shallower water from the Beaufort Group is taking place. These water level reactions could be due to possible seismic activity within close proximity to the dolerite ring structure and/or due to recharge and interflow to BHA.
Applicability of two non-radiographic tooth size prediction methods of unerupted permanent canine and premolars, for Galle district, Sri Lanka
Authors: Perera W. Kathya , Gunawardane Sumith , Pathirage Sumith Loku 
Published: September 2019

Introduction:
Mixed dentition space analysis necessitates accurate prediction of size of the unerupted permanent teeth. The methods commonly employed are the radiographs, correlation and regression equations, or a combination. Much interest was developed on the application of prediction tables and regression equations to avoid the radiation exposure. However, the predicted values and equations have been reported to be inaccurate on populations other than on which they were developed on. We intended to evaluate the applicability of the Moyer’s probability table and Tanaka Johnston equation in estimating the mesiodistal widths of mandibular and maxillary permanent canines and premolars in adolescents of the Galle District.

Material and Methods:
Data were collected from study models of 318 randomly selected school students aged 13– 16 years with fully erupted, intact dentitions and no significant malocclusion. The measurements were obtained by a digital caliper with a Vernier scale calibrated to the nearest 0.01 mm. The data were subjected to statistical analysis to compare the actual and predicted values from Moyer’s probability table and Tanaka Johnston equation.

Results:
There was a statistically significant difference when Pearson correlation two-tailed significance test was used. The actual mesiodistal width of permanent canines and premolars and predicted widths from Moyer’s probability chart at all levels for males and females showed a statistically significant difference at 0.01 level. The values from Tanaka Johnston equation also showed a statistically significant difference at P = 0.01/R = 0.47.

Conclusion:
Moyer’s prediction table and Tanaka Johnston equation must be carefully used for children in Galle District, Sri Lanka. Therefore, it might be safer to develop regression equations for our population.
A DAMAGE ANALYSIS OF SUCKER ROD STRING DUE TO EXCEEDS STRESS ON ARTIFICIAL LIFT SUCKER ROD PUMP WELL IR-01 TALANG AKAR PENDOPO FIELD
Authors: Melysa Richa , Musnal Ali 
Published: October 2019

ABSTRAK
Sumur IR-01 menggunakan sucker rod pump sebagai metode pengangkatan buatan dalam memproduksikan minyak. Data riwayat sumur pada tahun 2017 menunjukkan bahwa sering sekali mengalami permasalahan sucker rod putus, sehingga perlu dilakukan upaya pemecahan masalah. Analisis yang digunakan untuk mengetahui penyebab kerusakan rangkaian sucker rod pada sumur IR-01 adalah dengan melakukan perhitungan beban pada polished rod dan kinerja SRP secara teori, serta menggunakan interpretasi data hasil dynamometer test guna mendapatkan data aktual beban polished rod khususnya tingkat stress sucker rod di lapangan. Setelah dianalisis penyebab permasalahan maka dapat dilakukan upaya penanganan masalah dengan memberikan rekomendasi perencanaan ulang untuk mengatasi permasalahan sucker rod pada sumur IR-01.
Peran Perfeksionisme Orientasi Diri dalam Memediasi Pengaruh Gaya Pengasuhan Orang Tua terhadap Efikasi Diri Keputusan Karier Siswa
Authors: Utami Annisa Nurul , Suharso Puji Lestari , Salim Rose Mini Agoes 
Published: October 2019

This present study aimed to analyze the role of self-oriented perfectionism in mediating the effect of fathers’ and mothers’ parenting styles on Career Decision Self-Efficacy (CDSE) among students in Grade 11 Senior High School. The participants of the study comprised 179 students who were selected through convenience sampling method. This study employed three instruments, namely Career Decision Self-Efficacy Short Form, Parental Authority Questionnaire, and Multidimensional Perfectionism Scale. Data were analyzed by Hayes’s PROCESS Macro. Generally, the results show that fathers’ permissive parenting and mothers’ authoritarian parenting have an influence on the degree of CDSE among students which is mediated by self-oriented perfectionism. Moreover, the effect of fathers’ authoritative parenting predicts CDSE directly without the mediation effect of self-oriented perfectionism, whilst mothers’ authoritative parenting influences CDSE both directly and indirectly. Therefore, considering the actualization of proper parenting styles is necessary in order to build perfectionism personality which supports students’ effectiveness in career decision making.Keywords: Career decision self-efficacy, parenting styles, self-oriented perfectionism, studentsAbstrak: Penelitian ini bertujuan untuk menganalisis peran perfeksionisme orientasi diri dalam memediasi pengaruh gaya pengasuhan ayah dan ibu terhadap Efikasi Keputusan Diri Keputusan Karir (Career Decision Self-Efficacy/CDSE) siswa kelas XI SMA. Sebanyak 178 partisipan terkumpul melalui teknik convenience sampling dalam pengisian tiga macam skala, yaitu Career Decision Self-Efficacy Short Form, Parental Authority Questionnaire, dan Multidimensional Perfectionism Scale yang sudah dilakukan adaptasi ke dalam Bahasa Indonesia. Data dianalisis dengan menggunakan PROCESS Macro dari Hayes. Secara umum, hasil uji menemukan bahwa gaya pengasuhan permisif ayah dan gaya pengasuhan otoriter ibu berpengaruh terhadap tingkat CDSE siswa melalui perfeksionisme orientasi diri. Sementara itu, pengaruh dari gaya pengasuhan otoritatif ayah terhadap tingkat CDSE siswa hanya terjadi secara langsung. Adapun pengaruh dari gaya pengasuhan otoritatif ibu terhadap tingkat CDSE siswa dapat terjadi baik secara langsung atau tidak langsung melalui mediasi perfeksionisme orientasi diri. Untuk itu, dengan penerapan gaya pengasuhan yang tepat, perkembangan pribadi perfeksionisme siswa dapat mendukung kenaikan efektivitas keputusan karier masa depan.
Perbedaan Gender pada Kesadaran Metakognitif dalam Strategi Membaca Bacaan Akademik
Authors: Ardianingsih Wulansari , Salim Rose Mini Agoes 
Published: October 2019

Metacognitive awareness of reading strategies can be defined as the knowledge or awareness about strategies to process reading materials, the ability to monitor comprehension, and the ability to employ strategies in understanding text. Previous studies show inconsistent results regarding the role of gender in the metacognitive awareness of reading. The current study aims to evaluate gender differences in the students’ knowlegde of metacognitive strategies in reading. This study involves 137 students (59 boys and 78 girls) from grade 4 to 6. The current study uses Metacognitive Awareness of Reading Strategies Inventory (MARSI) that consists of 3 subscales: global strategy, problem solving, and support strategy. Results show that female students outperform male students in their metacognitive awareness, both in general scale and in each type of strategy. In addition, the most used strategy is the problem solving strategy, while the least used is the support strategy. This finding suggests that teachers need to consider the gender difference in determining the effective methods of delivering materials in classrooms. Keywords: metacognitive awareness, reading, gender differencesAbstrak: Kesadaran metakognitif dalam membaca dapat didefinisikan sebagai pengetahuan akan strategi untuk memproses bacaan, kemampuan untuk memonitor pemahaman, dan kemampuan untuk mengatur strategi yang dibutuhkan untuk memahami bacaan. Hingga saat ini masih terdapat hasil yang tidak konsisten mengenai peran gender dalam kesadaran metakognitif siswa. Penelitian ini bertujuan untuk menelaah lebih dalam mengenai bagaimana perbedaan siswa laki-laki dan perempuan pada kesadaran metakogntifnya dalam membaca, khususnya pada bacaan akademik. Penelitian melibatkan 137 siswa (59 laki-laki dan 78 perempuan) kelas 4 – 6 Sekolah Dasar (SD) dengan menggunakan alat ukur Metacognitive Awareness of Reading Strategies Inventory (MARSI) yang terdiri atas 3 dimensi: strategi global, penyelesaian masalah, dan strategi pendukung. Hasil penelitian menunjukkan bahwa siswa perempuan lebih sering menggunakan strategi metakognitif dibandingkan siswa laki-laki, baik secara keseluruhan maupun pada masing-masing jenis strategi. Selanjutnya, jenis strategi yang paling banyak dipakai adalah strategi penyelesaian masalah, sedangkan strategi yang paling jarang dipakai adalah strategi pendukung bacaan. Hasil penelitian ini berimplikasi pada kebutuhan guru untuk memperhatikan perbedaan gender siswa ketika menentukan metode penyampaian tugas atau materi belajar agar pembelajaran berlangsung efektif.