bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoxygenation before intubation in adult patients with acute hypoxemic respiratory failure: a network meta-analysis of randomized trials
Authors: Fong Ka Man , Au Shek Yin , Ng George Wing Yiu 
Published: September 2019

Abstract

Background
Patients with acute hypoxemic respiratory failure are at risk for life-threatening complications during endotracheal intubation. Preoxygenation might help reduce the risk of hypoxemia and intubation-related complications. This network meta-analysis summarizes the efficacy and safety of preoxygenation methods in adult patients with acute hypoxemic respiratory failure.

Methods
We searched PubMed, EMBASE, and the Cochrane Library Central Register of Controlled Trials through April 2019 for randomized controlled trials (RCT) that studied the use of conventional oxygen therapy (COT), high-flow nasal cannula (HFNC), noninvasive ventilation (NIV), and HFNC and NIV as preoxygenation before intubation in patients with acute hypoxemic respiratory failure. Citations’ screening, study selection, data extraction, and risk of bias assessment were independently performed by two authors. The primary outcome was the lowest SpO2 during the intubation procedure.

Results
We included 7 RCTs (959 patients). Patients preoxygenated with NIV had significantly less desaturation than patients treated with COT (mean difference, MD 5.53, 95% CI 2.71, 8.34) and HFNC (MD 3.58, 95% CI 0.59, 6.57). Both NIV (odds ratio, OR 0.43, 95% CI 0.21, 0.87) and HFNC (OR 0.49, 95% CI 0.28, 0.88) resulted in a lower risk of intubation-related complications than COT. There were no significant mortality differences among the use of NIV, HFNC, COT, and HFNC and NIV during preoxygenation.

Conclusions
In adult patients with acute hypoxemic respiratory failure, NIV is a safe and probably the most effective preoxygenation method.
First bloodstream infection caused by Prevotella copri in a heart failure elderly patient with Prevotella-dominated gut microbiota: a case report
Authors: Posteraro Patrizia , De Maio Flavio , Menchinelli Giulia , Palucci Ivana , Errico Federica Maria , Carbone Mariantonietta , Sanguinetti Maurizio , Gasbarrini Antonio , Posteraro Brunella 
Published: September 2019

Abstract

Background
Bloodstream infection (BSI) is a constant threat for hospitalized patients, and elderly patients are particularly susceptible to BSI caused by anaerobic bacteria. Changes in the gut microbiota composition may lead to pathogen overgrowth and translocation into the bloodstream. Consequently, domination of specific taxa in the intestinal bacterial community seems to be associated with a higher risk of bacteremia in some patient populations.

Case presentation
Here, we report the case of a 90-year-old heart failure (HF) patient who was admitted to the hospital for an acute state of cardiac decompensation. Twenty days after admission, he was febrile to 38.2 °C whereas his white blood count and C-reactive protein increased to 6190 cells/μL and 31.2 mg/L, respectively. Of the patient’s blood culture (BC) bottle pairs collected under the suspicion of infection, the anaerobic bottle yielded an organism that was later identified as Prevotella copri. Concomitantly, the patient’s fecal sample was obtained for the intestinal microbiota characterization by sequencing the V3/V4/V6 regions of the bacterial 16S rRNA gene. The analysis revealed highest relative abundances of Bacteroidales (34.1%), Prevotellaceae (19.0%), Prevotella (15.2%), and P. copri (6.1%) taxa, indicating that the patient’s gut microbiota was dominated by Prevotella organisms. The patient was successfully treated with metronidazole, and was discharged to a long-term care facility at 35 days of admission.

Conclusions
We provide the first evidence for a clinically significant BSI caused by P. copri and its relationship to a Prevotella-rich gut microbiota in the HF patient setting. When strengthening the pathogenicity of P. copri, the present case suggests that the gut may be a source of BSI caused by the rare anaerobic organism. Future studies are necessary to assess the role of the gut microbiota profiling for precise identification and targeted treatment of patients at high risk of BSI.
Delays in diagnosis and treatment of pulmonary tuberculosis in patients seeking care at a regional referral hospital, Uganda: a cross sectional study
Authors: Muttamba Winters , Kyobe Samuel , Komuhangi Alimah , Lakony James , Buregyeya Esther , Mabumba Eldad , Basaza Robert K. 
Published: September 2019

Abstract

Objective
A cross-sectional survey involving 134 pulmonary TB patients started on TB treatment at the TB Treatment Unit of the regional referral hospital was conducted to ascertain the prevalence of individual and health facility delays and associated factors. Prolonged health facility delay was taken as delay of more than 1 week and prolonged patient delay as delay of more than 3 weeks. A logistic regression model was done using STATA version 12 to determine the delays.

Results
There was a median total delay of 13 weeks and 110 (82.1%) of the respondents had delay of more than 4 weeks. Patient delay was the most frequent and greatest contributor of total delay and exceeded 3 weeks in 95 (71.6%) respondents. At multivariate analysis, factors that influenced delay included poor patient knowledge on TB (adjOR 6.904, 95% CI 1.648–28.921; p = 0.04) and being unemployed (adjOR 3.947, 95% CI 1.382–11.274; p = 0.010) while being female was found protective of delay; adjOR 0.231, 95% CI 0.08–0.67; p = 0.007). Patient delay was the most significant, frequent and greatest contributor to total delay, and factors associated with delay included being unemployed, low knowledge on TB while being female was found protective of delay.
An audit of mother to child HIV transmission rates and neonatal outcomes at a tertiary hospital in South Africa
Authors: Benali Ghad , Ramdin Tanusha , Ballot Daynia 
Published: September 2019

Abstract

Objective
The aim of this study was to explore the prevalence of congenital HIV infection of neonates at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) between 2015 and 2017, as well as compare the HIV PCR positive and HIV PCR negative neonates.

Results
A total number of 1443 HIV exposed neonates was examined for the study period out of a total of 5029 admissions (HIV exposure 28.6%) The study found that the rate of HIV transmission at birth was 2.52%. The majority of infants had low birth weight and were also born prematurely. These results show that, despite the introduction of the extended mother to child transmission programme, HIV transmission is high.
Screening circulating proteins to identify biomarkers of fetal macrosomia
Authors: Cruickshank Tess , Kaitu’u-Lino Tu’uhevaha J. , Cannon Ping , Harper Alesia , Nguyen Tuong-Vi , Dane Kirsten M. , Middleton Anna L. , Kyritsis Valerie P. , Hastie Roxanne , Tong Stephen , Walker Susan P. , MacDonald Teresa M. 
Published: September 2019

Abstract

Objective
Fetal macrosomia is a major risk factor for shoulder dystocia, which can lead to birth asphyxia, maternal and neonatal traumatic injuries, and perinatal death. If macrosomia is diagnosed in the antenatal period, labour can be induced to decrease shoulder dystocia. But current clinical methods to diagnose fetal macrosomia antenatally perform with poor accuracy. Therefore, improved methods to accurately diagnose fetal macrosomia are required. Blood biomarkers that predict fetal macrosomia could be one such novel diagnostic strategy. We undertook a nested case–control study from a prospective collection of 1000 blood samples collected at 36 weeks’ gestation. We analysed plasma samples from 52 women who subsequently delivered a macrosomic (> 95th centile for gestational age) infant and 106 controls. Circulating concentrations of the proteins COBLL1, CSH1, HSD3B1, EGFL6, XAGE3, S100P, PAPPA-1, ERBB2 were assessed for their ability to predict macrosomic infants.

Results
We did not identify any significant changes in the plasma concentrations of COBLL1, CSH1, HSD3B1, EGFL6, XAGE3, S100P, PAPPA-1, ERBB2 from women who subsequently delivered macrosomic neonates relative to control samples. Although we have not identified any potential biomarkers of fetal macrosomia, we have ruled out these particular eight protein candidates.
Awareness of complications of diabetes mellitus and its associated factors among type 2 diabetic patients at Addis Zemen District Hospital, northwest Ethiopia
Authors: Belsti Yitayeh , Akalu Yonas , Fekadu Haileab , Animut Yaregal 
Published: September 2019

AbstractObjectivesAwareness about complications is important to reduce diabetes related morbidity and mortality. This study aimed to assess awareness of diabetes complications and associated factors among type 2 diabetic patients. Institution based cross sectional study was conducted from April to June, 2019, using simple random sampling technique, and interviewer administered questionnaires.ResultsThe mean age was 41 ± 1.46 years and 56% were females. Awareness regarding diabetic complications was 48.5% with 95% CI (43.3, 52.7%). Male sex (AOR: 4.67, 95% CI (2.53, 8.61)), age of 31–45 years (AOR: 7.30, 95% CI (3.10, 17.17)), 46–70 years old (AOR: 15.02, 95% CI (6.11, 36.92)), read and write (AOR: 3.79, 95% CI (1.78, 8.06)), primary school (AOR: 9.58, 95% CI (3.26, 28.18)), high school and above (AOR: 7.46, 95% CI (3.02, 18.44)), NGO employee (AOR: 7.24, 95% CI (2.68, 19.53)), having a family history of DM (AOR: 5.55, 95% CI (2.53, 12.20)); income of 1001–1500 (AOR: 3.22, 95% CI (1.28, 8.10)), 1501–2500 (AOR: 11.73, 95% CI (4.32, 31.81)) and > 2500 Ethiopian birr (AOR: 7.18, 95% CI (1.70, 30.28)) ≥ 2500 ETB (AOR: 7.18, 95% CI (1.70, 30.28)) were significantly associated with good awareness. To improve patient’s awareness on DM complications providing health education for type 2 diabetic patients is crucial.
Sensitivity analysis for a new class of generalized parametric nonlinear ordered variational inequality problems in ordered Banach spaces
Authors: Nisar Kottakkaran Sooppy , Sarfaraz Mohd. , Morsy Ahmed , Ahmad Md. Kalimuddin 
Published: September 2019

Abstract
In this study, we introduce a class of new generalized parametric nonlinear ordered variational inequality problems and discuss its existence result. Also, we prove the sensitivity of the solution for the parametric inequality class with the help of B-restricted-accretive method in ordered Banach spaces. Some special cases of the main results are also discussed.
Structurally isolated photoactuation of graphene-mixed temperature-responsive hydrogels in soft-rigid series structure
Authors: Watanabe Tomoki , Yokoyama Yoshiyuki , Hayakawa Takeshi 
Published: September 2019

Abstract
This paper presents fabrication and actuation methods for a soft microrobot with a hybrid structure composed of soft microactuators and a rigid supporting body. This hybrid structure enables actuation of the microrobot with independent driving of multiple actuators to provide complex movement like that of living microorganisms. We use the temperature-responsive hydrogel poly(N-isopropylacrylamide) (PNIPAAm) as a soft microactuator. PNIPAAm swells with water at low temperature but shrinks at high temperature. This volume change thus allows PNIPAAm to be used as an actuator by controlling its temperature. We successfully fabricated the microrobot with its soft-rigid hybrid structure composed of PNIPAAm and rigid photoresist using a multilayered microfabrication process. In addition, we used a sacrificial layer process to release the fabricated microrobot from the substrate to allow it to move freely. To actuate the microrobot, we mixed PNIPAAm with graphene, which has a high photothermal conversion efficiency. The temperature of the soft actuator when mixed with graphene can be increased by irradiating it with light. Therefore, actuation of the microrobot is achieved by sequentially irradiating the microactuators with focused light. We present the fabrication, release and partial actuation of the microrobot to demonstrate the feasibility of the proposed microrobot with the soft-rigid hybrid structure in this paper.
Species delimitation within the Glaucidium brodiei owlet complex using bioacoustic tools
Authors: Gwee Chyi Yin , Eaton James A. , Ng Elize Y. X. , Rheindt Frank E. 
Published: September 2019

Abstract

Background
The taxonomy of the Collared Owlet (Glaucidium brodiei) species complex is confused owing to great individual variation in plumage colouration seemingly unrelated to their distribution. Although generally recognised as a single species, vocal differences among the subspecies have been noted by field recordists. However, there is no study assessing the vocal differences among these four subspecies.

Methods
We obtained 76 sound recordings of the G. brodiei species complex comprising all four subspecies. We conducted bioacoustic examinations using principal component analysis and the Isler criterion to quantitatively test species boundaries within the G. brodiei complex. In addition, we compared plumage colouration among 13 specimens of the G. brodiei complex deposited at the Natural History Museum at Tring, UK and the Lee Kong Chian Natural History Museum, Singapore to ascertain the presence of plumage differences across taxa.

Results
We found the Bornean and Sumatran populations vocally similar to each other, but distinctly different from the mainland and Taiwan populations. The vocal pattern seems to corroborate plumage distinctions in the colouration of neck collars: the Bornean and Sumatran taxa share a white neck collar, whereas the continental and Taiwan taxa share a rufous neck collar.

Conclusions
We propose the taxonomic elevation of the Sumatran and Bornean populations to species level as Sunda Owlet G. sylvaticum, with one subspecies on Sumatra (G. s. sylvaticum) and Borneo (G. s. borneense) each. Our study corroborates the importance of bioacoustics in ascertaining species boundaries in non-passerines, and emphasises the significance of incorporating multiple species delimitation approaches when making taxonomic decisions.
Characterization the effects of nanofluids and heating on flow in a baffled vertical channel
Authors: Al-Obaidi Ali Assim , Salman Ali J. , Yousif Ali Raheem , Al-Mamoori Dalya H. , Mussa Mohamed H. , Gaaz Tayser Sumer , Kadhum Abdul Amir H. , Takriff Mohd S. , Al-Amiery Ahmed A. 
Published: September 2019

Abstract
The laminar 2-D blended convection of the nanofluids at different volume fractions has gained interest in the last decade due to an enormous application in technology. The laminar-flow stream system can be further modified by changing the geometry of the channel, adding an external heating source, and changing the initial conditions at which the stream is being influenced. The investigation of this system includes the variation of the geometrical parameters of the channel, Reynolds number, Nusselt number, and type of the nanoparticles used in preparing the nanofluid with water as the base fluid. These parameters constitute a very successful leading to utilize the numerical solutions by using a finite volume method. Regarding heat flow, one side of the channel was supplied by the heat while the temperature of the other side was kept steadily. The upstream walls of the regressive confronting step were considered as adiabatic surfaces. The nanofluids were made by adding aluminum oxide (Al2O3), copper oxide (CuO), silicon dioxide (SiO2), or zinc oxide (ZnO) nanoparticles to various volume fractions in the scope of 1 to 4% and diverse nanoparticle diameters of 25 to 80 nm. The calculations were performed with heat flux, Reynolds numbers (Re), and step height (S) at a range of 100 <  < 600 W/m2, 100 <  Re  < 500, and 3 ≤ S ≤ 5.8, respectively. The numerical study has shown that the nanofluid with SiO2 has the highest value of the Nusselt number (Nu). The distribution area and the Nu increase as Reynolds number increases and diminish as the volume fraction diminishes with the increase of the nanoparticle diameter. The outcome of this paper has shown that assisting flow has shown superiority over the opposing flow when Nu increases.
Laparoscopic surgical management of a mature presacral teratoma: a case report
Authors: Wang Liming , Hirano Yasumitsu , Ishii Toshimasa , Kondo Hiroka , Hara Kiyoka , Ishikawa Shintaro , Okada Takuhisa , Obara Nao , Yamaguchi Shigeki 
Published: September 2019

Abstract

Background
Mature presacral (retrorectal) teratoma is very rare. We report a case in which a mature retrorectal teratoma in an adult was successfully treated with laparoscopic surgery.

Case presentation
A 44-year-old woman was diagnosed with a presacral tumor during a physical examination. Endoscopic ultrasonography (EUS) revealed a multilocular cystic lesion; the lesion was on the left side of the posterior rectum and measured approximately 30 mm in diameter on both contrast-enhanced pelvic computed tomography (CT) and magnetic resonance imaging (MRI). The presumptive diagnosis was tailgut cyst. However, the histopathological diagnosis after laparoscopic resection was mature teratoma. It is still difficult to preoperatively diagnose mature retrorectal teratomas.

Conclusions
Laparoscopic resection of mature retrorectal teratomas is a feasible and promising method that is less invasive and can be adapted without extending the skin incision.
[11C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years
Authors: Taddei Carlotta , Pike Victor W. 
Published: September 2019

Abstract
[11C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and the present-day broad versatility of carbonylation reactions have led to an upsurge in the production of this synthon and in its application to PET radiotracer development. This review focuses on the major advances of the past 15 years.
Systemic anaplastic large cell lymphoma presenting as a huge mediastinal mass in a case of hyper IgE syndrome: a case report
Authors: Kheyrollahiyan Atefeh , Sharifi Akbar , Mirza-Aghazadeh-Attari Mohammad 
Published: September 2019

Abstract

Background
Hyper IgE syndrome is a rare heterogeneous immunodeficiency syndrome which is characterized by recurrent episodes of cutaneous and respiratory tract infections and development of cold abscesses. This syndrome is also associated with malignancies, most notability hematologic malignancies.

Case presentation
In this case report, we discuss a 27-year-old male with proven hyper IgE syndrome and effected by tuberculosis, who developed an anaplastic large cell lymphoma, a very rare and aggressive subtype of lymphoma. We will discuss imaging findings in this rare case. The case presented here had a large mediastinal mass, which had encircled the aorta, and was accompanied by subcarinal lymphadenopathy and inguinal lymphadenopathy.

Conclusions
Systemic anaplastic large cell lymphoma is a rare subtype of lymphoma which is rarely associated with hyper IgE syndrome. In this case, both lymphoma and tuberculosis infection were witnessed in the same patient, showing a classic example of immune dysregulation.
The weeks before 100 persecutory delusions: the presence of many potential contributory causal factors
Authors: Freeman Daniel , Morrison Anthony , Bird Jessica C. , Chadwick Eleanor , Bold Emily , Taylor Kathryn M. , Diamond Rowan , Collett Nicola , Černis Emma , Isham Louise , Lister Rachel , Kirkham Miriam , Teale Ashley-Louise , Twivy Eve , Waite Felicity 
Published: September 2019

Background
The period before the formation of a persecutory delusion may provide causal insights. Patient accounts are invaluable in informing this understanding.

Aims
To inform the understanding of delusion formation, we asked patients about the occurrence of potential causal factors – identified from a cognitive model – before delusion onset.

Method
A total of 100 patients with persecutory delusions completed a checklist about their subjective experiences in the weeks before belief onset. The checklist included items concerning worry, images, low self-esteem, poor sleep, mood dysregulation, dissociation, manic-type symptoms, aberrant salience, hallucinations, substance use and stressors. Time to reach certainty in the delusion was also assessed.

Results
Most commonly it took patients several months to reach delusion certainty (n = 30), although other patients took a few weeks (n = 24), years (n = 21), knew instantly (n = 17) or took a few days (n = 6). The most frequent experiences occurring before delusion onset were: low self-confidence (n = 84); excessive worry (n = 80); not feeling like normal self (n = 77); difficulties concentrating (n = 77); going over problems again and again (n = 75); being very negative about the self (n = 75); images of bad things happening (n = 75); and sleep problems (n = 75). The average number of experiences occurring was high (mean 23.5, s.d. = 8.7). The experiences clustered into six main types, with patients reporting an average of 5.4 (s.d. = 1.0) different types.

Conclusions
Patients report numerous different experiences in the period before full persecutory delusion onset that could be contributory causal factors, consistent with a complex multifactorial view of delusion occurrence. This study, however, relied on retrospective self-report and could not determine causality.

Declaration of interest
None.
Management of Osteoporosis in Survivors of Adult Cancers With Nonmetastatic Disease: ASCO Clinical Practice Guideline
Authors: Shapiro Charles L. , Van Poznak Catherine , Lacchetti Christina , Kirshner Jeffrey , Eastell Richard , Gagel Robert , Smith Sean , Edwards Beatrice J. , Frank Elizabeth , Lyman Gary H. , Smith Matthew R. , Mhaskar Rahul , Henderson Tara , Neuner Joan 
Published: September 2019

PURPOSE The aim of this work is to provide evidence-based guidance on the management of osteoporosis in survivors of adult cancer. METHODS ASCO convened a multidisciplinary Expert Panel to develop guideline recommendations based on a systematic review of the literature. RESULTS The literature search of the 2018 systematic review by the US Preventive Services Task Force in the noncancer population was used as the evidentiary base upon which the Expert Panel based many of its recommendations. A total of 61 additional studies on topics and populations not covered in the US Preventive Services Task Force review were also included. Patients with cancer with metastatic disease and cancer survival outcomes related to bone-modifying agents are not included in this guideline. RECOMMENDATIONS Patients with nonmetastatic cancer may be at risk for osteoporotic fractures due to baseline risks or due to the added risks that are associated with their cancer therapy. Clinicians are advised to assess fracture risk using established tools. For those patients with substantial risk of osteoporotic fracture, the clinician should obtain a bone mineral density test. The bone health of all patients may benefit from optimizing nutrition, exercise, and lifestyle. When a pharmacologic agent is indicated, bisphosphonates or denosumab at osteoporosis-indicated dosages are the preferred interventions.