bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mobile health untuk meningkatkan self-management pada pasien diabetes mellitus: A literature review
Authors: Ikawati Dewi , Kurniawan Titis , Pahria Tuti 
Published: November 2024

Background: Diabetes Mellitus causes serious complications with increasing incidence rates, due to the lack of patient support for self-management. The current rise in innovation, one of which is the use of mobile health which can be used for self-management interventions for diabetes patients
Purpose: To determine the potential for developing mobile health applications in improving self-management of diabetes mellitus patients.
Method: Literature review research accessed from several databases such as CINAHL, Scopus, Pubmed, and Google Scholar, published in the last 5 years in the range of 2019-2024. The keywords used are "Self-Management", "Mobile-Health" or Mobile Applications, "Diabetes Mellitus". Article assessment uses the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
Results: The use of mobile health applications can improve glycemic control, namely reducing HbA1c levels, fasting and post-prandial blood glucose and contributing to reducing BMI.
Conclusion: Providing interventions with mobile health has been shown to improve self-management in DM patients.

Keywords: Diabetes Mellitus; Mobile Health; Self-Management.

Pendahuluan: Penyakit diabetes mellitus (DM) menimbulkan komplikasi yang serius dengan angka kejadiannya yang semakin meningkat. Salah satu faktor yang menyebabkan penyakit DM yaitu kurangnya dukungan pasien terhadap self-management. Salah satu inovasi penanganan penyakit saat ini adalah penggunaan mobile health yang dapat digunakan untuk intervensi self-management terhadap pasien diabetes
Tujuan: Untuk mengetahui potensi pengembangan aplikasi mobile health dalam meningkatkan self-management pasien diabetes mellitus.
Metode: Penelitian literature review diakses dari beberapa database seperti CINAHL, Scopus, Pubmed, dan Google Scholar, diterbitkan 5 tahun terakhir pada rentang 2019-2024. Kata kunci yang digunakan yaitu “Self-Management”, “Mobile-Health” or Mobile Applications, “Diabetes Mellitus”. Penilaian artikel menggunakan panduan Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).
Hasil: Penggunaan aplikasi mobile health dapat meningkatkan kontrol glikemik, yaitu penurunan kadar HbA1c, glukosa darah puasa, dan postprandial serta berkontribusi dalam penurunan BMI.
Simpulan: Pemberian intervensi dengan mobile health terbukti dapat meningkatkan self-management pada pasien DM.

Kata Kunci: Diabetes Mellitus; Mobile Health; Self-Management.
Assessing the predictive potential of ADAM8 for disease control in chronic rhinosinusitis with nasal polyps
Authors: Liu Peiqiang , Liu Meng , Sun Yibin , Lei Weiwei , Xu Yu 
Published: November 2024

BackgroundA disintegrin and metalloproteinase 8 (ADAM8) has been implicated in eosinophilic inflammation; however, its role in chronic rhinosinusitis with nasal polyps (CRSwNP) remains to be elucidated. This study aimed to investigate the predictive significance of ADAM8 levels in nasal secretions for the endotypes and disease control status of CRSwNP.MethodsA cohort comprising 120 CRSwNP patients and 45 healthy controls (HCs) was assembled, delineating 53 non-eosinophilic CRSwNP (neCRSwNP) and 67 eosinophilic CRSwNP (eCRSwNP) patients. Immunohistochemistry and enzyme-linked immunosorbent assay (ELISA) were utilized to measure ADAM8 levels in nasal mucosal tissues and secretions from all participants. The receiver operating characteristic (ROC) curves and Pearson correlation analysis were employed to assess the predictive capability of ADAM8 levels in predictiving CRSwNP endotypes and disease control status.ResultsADAM8 levels in nasal secretions were elevated in CRSwNP patients compared to HCs, with a more pronounced increase observed in eCRSwNP patients. Elevated ADAM8 concentrations in nasal secretions were positively correlated with peripheral blood eosinophil counts and percentages, tissue eosinophil counts, serum total IgE, Lund–Mackay scores, and Lund-Kennedy scores. Ultimately, 103 CRSwNP patients completed the follow-up protocol, with 72 classified as the controlled group and 31 as the uncontrolled group. Uncontrolled CRSwNP patients exhibited significantly higher ADAM8 levels in nasal secretions compared to the controlled group. The ROC curves indicated that ADAM8 in nasal secretions exhibits robust discriminatory capacity for eCRSwNP and postoperative disease control status.ConclusionADAM8 in nasal secretions emerges as a potential novel biomarker for the prognostication of CRSwNP endotypes and the postoperative disease control status.
Triglyceride to high-density lipoprotein cholesterol ratio is associated with diabetes incidence in non-obese individuals with normoglycemia: a retrospective cohort study based on individuals from East Asia
Authors: Huang Zhenhua , Zhang Xigang , Sun Dayong , Yu Ke 
Published: November 2024

BackgroundAlthough several studies have explored the association between the triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-c) and diabetes risk, most of these studies are cross-sectional and typically involve small sample sizes, limiting the ability to draw causal inferences. Additionally, there is currently a few studies specifically focusing on non-obese individuals. Consequently, we conducted a retrospective cohort study to investigate the impact of TG/HDL-c on the risk of developing diabetes among non-obese, normoglycemic individuals across East Asian countries.MethodsThis secondary retrospective cohort study recruited 85,029 non-obese individuals with normal glycemic levels from East Asian countries (China and Japan). We employed Cox proportional hazards regression models, incorporating cubic splines function for smooth curve fitting and using two-piecewise Cox regression for threshold effect analysis, to evaluate the nonlinear associations between baseline TG/HDL-c ratios and diabetes risk in non-obese individuals with normoglycemia. In addition, A range of subgroup and sensitivity analyses were performed to confirm the robustness of our results.ResultsAmong the individuals included, the average age was 42.14 ± 11.88 years, and 37,944 participants (44.62%) were male. After adjusting for covariates, the study revealed a significant correlation between the TG/HDL-c ratio and the risk of diabetes among non-obese individuals (HR=1.37, 95%CI: 1.22-1.54). Furthermore, a non-linear correlation was observed between the TG/HDL-c ratios and the incidence of non-obese diabetes, with an inflection point of 1.36. Under this threshold, the TG/HDL-c ratio notably boosts diabetes risk in non-obese populations, with an HR of 2.38 (95% CI: 1.57-3.59). Conversely, beyond the critical juncture, the upsurge in diabetes risk seems to level off, displaying no significant variation, with an HR of 1.18 (95% CI: 0.98-1.41).ConclusionsThis study reveals a non-linear association between the TG/HDL-c ratios and the likelihood of diabetes in non-obese individuals from East Asia. Maintaining a ratio of TG/HDL-C below 1.36 significantly reduces diabetes risk. However, once the ratio of TG/HDL-C exceeds 1.36, reducing it does not substantially lower diabetes onset risk.
Potential effects of peripheral neuropathy on brain function in patients with type 2 diabetes mellitus
Authors: Zhang Dongsheng , Huang Yang , Zhang Xiaoling , Liu Wanting , Guan Yitong , Gao Jie , Lei Xiaoyan , Tang Min , Ai Kai , Yan Xuejiao 
Published: November 2024

BackgroundThe mechanisms associated between diabetic peripheral neuropathy (DPN) and various brain function abnormalities in patients remains unclear. This study attempted to indirectly evaluate the effect of DPN on brain function in patients with type 2 diabetes mellitus (T2DM) by characterizing the resting-state functional connectivity (FC) of the lower limb sensorimotor cortex (LSM).MethodsForty-four T2DM patients with diabetic peripheral neuropathy (DPN), 39 T2DM patients without diabetic peripheral neuropathy (ND), and 43 healthy controls (HCs) underwent a neuropsychological assessment and resting-state functional magnetic resonance imaging examinations to examine the differences in FC between the LSM and the whole brain. The relationships of FC with clinical/cognitive variables were examined.ResultsIn comparison with the HCs group, the ND group showed reduced FC of the LSM with the right lateral occipitotemporal cortex (LOTC) and increased FC with the medial superior frontal gyrus (SFGmed), while the DPN group showed reduced FC of the LSM with the right cerebellar lobule VI, the right LOTC, the rostral prefrontal cortex (rPFC), and the anterior cingulate gyrus (ACC). Moreover, in comparison with the ND group, the DPN group showed reduced FC of the LSM with the ACC, SFGmed, and rPFC. In the DPN group, the FC between the LSM and right cerebellar lobule VI was significantly correlated with fasting blood glucose levels (r = -0.490, p = 0.001), and that between the LSM and ACC was significantly correlated with the Montreal Cognitive Assessment score (r = 0.479, p = 0.001).ConclusionsPatients with T2DM may show abnormal motion-related visual perceptual function before the appearance of DPN. Importantly, DPN can influence the brain regions that maintain motion and motor control, and this effect is not limited to motor function, which may be the central neuropathological basis for diabetic peripheral neuropathy.
Reduced expression of FOXE1 in differentiated thyroid cancer, the contribution of CPG methylation, and their clinical relevance
Authors: De Lima Erika Urbano , Dos Santos Filipe Ferreira , Da Silva Igor Campos , De Lima Cláudio Rogério Alves , Frutuoso Vitoria Sousa , Caso Gustavo Felisola , De Oliveira Paloma Ramos , Bezerra Ana Karina , Cerutti Janete Maria , Tamura Rodrigo Esaki , Ramos Helton Estrela , Rubio Ileana Gabriela Sanchez de 
Published: November 2024

IntroductionForkhead box E1 (FOXE1) is a transcription factor with a crucial role in thyroid morphogenesis and differentiation. Promoter hypermethylation downregulates FOXE1 expression in different tumor types; nevertheless, its expression and relationship with methylation status in differentiated thyroid cancer (DTC) remain unclear.MethodsA total of 33 pairs of matched samples of PTC tumors and non-tumors were included. Tumor cell cultures were treated with either 5-Aza-2′-deoxycytidine demethylating agent or dimethyl sulfoxide (DMSO). A real-time polymerase chain reaction (RT-PCR) and Western blotting were performed to assess FOXE1 expression. The methylation status was quantified using bisulfite sequencing. A luciferase gene assay was used to determine CpG-island functionality. Gene expression and promoter methylation of FOXE1 and FOXE1-regulated genes were also analyzed with data from The Cancer Genome Atlas (TCGA) thyroid samples.ResultsAfter demethylating treatment, increased FOXE1 mRNA was observed concomitantly with reduced promoter methylation of CpGisland2. A negative correlation between mRNA downregulation and an increased methylation level of CpGisland2 was observed in tumors. Diminished protein expression was also detected in some DTC cell lines and in some tumor samples, suggesting the involvement of post-transcriptional regulatory mechanisms. CPGisland2 was proved to be an enhancer. TCGA data analysis showed low FOXE1 mRNA expression in tumors with a negative correlation with methylation status and a positive correlation with the expression of most of its target genes. Reduced FOXE1 expression, accompanied by a high methylation level, was associated with PTC aggressiveness (tall cell variant, advanced extra thyroid extension, T4 American Joint Committee on Cancer (AJCC) classification), age at diagnosis (over 45 years old), and presence of a BRAFV600E mutation.ConclusionFOXE1 mRNA was downregulated in DTC compared with non-tumors, followed by high CpGisland methylation. A coupling of low mRNA expression and high methylation status was related to characteristics of aggressiveness in DTC tumors.
AI-enabled pipeline for virus detection, validation, and SNP discovery from next-generation sequencing data
Authors: Ghorbani Abozar , Rostami Mahsa , Guzzi Pietro Hiram 
Published: November 2024

Background and AimsThe rapid and accurate detection of viruses and the discovery of single nucleotide polymorphisms (SNPs) are critical for disease management and understanding viral evolution. This study presents a pipeline for virus detection, validation, and SNP discovery from next-generation sequencing (NGS) data. The pipeline processes raw sequencing data to identify viral sequences with high accuracy and sensitivity by integrating state-of-the-art bioinformatics tools with artificial intelligence.MethodsBefore aligning the reads to the reference genomes, quality control measures, and adapter trimming are performed to ensure the integrity of the data. Unmapped reads are subjected to de novo assembly to reveal novel viral sequences and genetic elements.ResultsThe effectiveness of the pipeline is demonstrated by the identification of virus sequences, illustrating its potential for detecting known and emerging pathogens. SNP discovery is performed using a custom Python script that compares the entire population of sequenced viral reads to a reference genome. This approach provides a comprehensive overview of viral genetic diversity and identifies dominant variants and a spectrum of genetic variations.ConclusionThe robustness of the pipeline is confirmed by the recovery of complete viral sequences, which improves our understanding of viral genomics. This research aims to develop an auto-bioinformatics pipeline for novel viral sequence discovery, in vitro validation, and SNPs using the Python (AI) language to understand viral evolution. This study highlights the synergy between traditional bioinformatics techniques and modern approaches, providing a robust tool for analyzing viral genomes and contributing to the broader field of viral genomics.
Sex discrepancies in cancer research: a systematic review of prospective and retrospective investigations in lung, melanoma, and colorectal cancers
Authors: Díaz Rosario Maria , Vélez-Morell Camille A. , Martinez Daniela V. 
Published: November 2024

IntroductionAccording to the latest Cancer Statistics, colorectal, lung, and melanoma are three of the most common cancers that affect both males and females. While males have consistently had a higher incidence and mortality rate in all three types of cancers, females have been shown to have better outcomes. Sex discrepancies in cancer research can impact the efficacy and effectiveness of novel drugs and diagnostic tools. Study results may not accurately represent how the treatment or diagnostic tool performs in the underrepresented sex. To comprehensively assess sex representation in top non-sex-specific cancer research, this systematic review aims to identify if there is equal representation of males and females in colorectal, lung, and melanoma cancer research.MethodsWe explored retrospective and prospective clinical studies published in Pubmed from 2014 to 2023 to identify possible sex discrepancies in colorectal, lung, and melanoma cancer. MeSH terms were employed to retrieve relevant studies for each cancer type (colorectal, lung, melanoma). MeSH terms used include “lung cancer”, “melanoma”, and “colorectal cancer”, in combination with “trials”, “retrospective”, and “prospective”. Extracted data included study characteristics (author, year of publication), study design (prospective or retrospective), sample size, and the number of male and female participants.ResultsThe complete study population consisted of 515,003 patients, of which 275,231 (53%) were males and 237,488 (46%) were females. Specifically, retrospective studies included a total of 302,974 patients with 163,473 (54%) of them identifying as male and 139,072 (46%) patients identifying as female. While prospective studies included a total of 212,029 patients with 111,758 (53%) of these being male and 98,416 (46%) being female. Overall, male representation in the studies included in this systematic review was higher than female representation.DiscussionDisparities in representation were identified in colorectal cancer, lung cancer, and melanoma cancer studies underscoring the need for equitable inclusion of both sexes in cancer research to advance precision medicine and improve patient outcomes. Further exploration of the impact of sex, race, and socioeconomic status on study representation is warranted.
Pressure-tolerant survival mechanism of Schizophyllum commune 20R-7-F01 isolated from deep sediments 2 kilometers below the seafloor
Authors: Zhao Mengshi , Li Dongxu , Liu Jie , Fang Jiasong , Liu Changhong 
Published: November 2024

In anaerobic high hydrostatic pressure (HHP) sedimentary environments below the seafloor, fungi are found to dominate the eukaryotic communities, playing crucial ecological roles. However, the specific mechanisms by which fungi adapt to anaerobic HHP environments remain unclear. In this study, we investigated Schizophyllum commune 20R-7-F01 isolated from coal-bearing sediments at a depth of 2 km below the seafloor. By assessing the cell viability, biomass, and cell wall thickness changes of strain 20-7-1 under different HHP conditions, we observed that, compared to 0.1 MPa, strain 20-7-1 exhibited slower growth rates and decreased cell viability at 15 MPa and 35 MPa, yet demonstrated significant pressure tolerance. Transcriptomic and metabolomic analyses revealed that this strain activated the carbohydrate metabolic process to simultaneously utilize ethanol and lactic acid fermentation pathway. Additionally, it activates the oxidoreductase activity and hydrolase activity pathways to detoxify intracellular reactive oxygen species (ROS). Activation of the metal ion binding pathway increases the proportion of unsaturated fatty acids in the cell membrane, while instigation of the integral component of membrane pathway maintains cell wall structural stability. Furthermore, activation of the DNA repair pathway repairs DNA damage, demonstrating its comprehensive adaptive mechanisms against the HHP stress. These research findings deepen our understanding of fungal survival strategies and adaptation mechanisms in extreme environments, laying the groundwork for further exploration of their roles in cycling of carbon, nitrogen, sulfur, and other elements in the deep biosphere.
Effect of traditional Chinese Yijinjing exercise on hand dysfunction in rheumatoid arthritis patients: a randomized controlled trial
Authors: Chang Tian , Ma Xieli , Gong Xun , Xia Congmin , Jiang Quan , Zhang Rouman 
Published: November 2024

IntroductionRheumatoid arthritis (RA) patients often experience significant hand dysfunction. Yijinjing, a traditional Chinese exercise, has been recognized for its benefits to mind–body health. This study aimed to evaluate the efficacy and safety of Yijinjing in improving hand dysfunction among individuals with RA.MethodsThis research was conducted as a single-center, outcome-blinded, randomized controlled trial. A total of 66 eligible RA participants were randomly assigned in a 1:1 ratio to either the Yijinjing exercise group (YJJG) with sessions conducted three times per week over a 12-week period or the control group (CG), which maintained ordinary activities. Various outcomes were assessed, including the Michigan Hand Outcomes Questionnaire (MHQ), handgrip strength, active range of motion (AROM), RA disease activity, the Health Assessment Questionnaire Disability Index (HAQ-DI), levels of anxiety and depression, and wrist ultrasound, all of which were collected at baseline and the week 12.ResultsAt the end of the 12 weeks, the YJJG demonstrated significant improvements in MHQ scores compared to the CG (p &lt; 0.05), alongside enhancements in handgrip strength and AROM, specifically in wrist extension, radial deviation, and metacarpophalangeal flexion (p &lt; 0.05). Wrist ultrasound scores did not exhibit a significant increase in the YJJG, meaning no inflammation aggravation (p &gt; 0.05). Additionally, morning stiffness duration, Disease Activity Score 28-ESR (DAS28-ESR), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels showed significant improvement in the YJJG (p &lt; 0.05). Both groups reported enhancements in quality of life, as well as reductions in anxiety and depression scores, with the YJJG displaying greater improvements overall (p &lt; 0.05). Importantly, no adverse events or significant abnormalities in vital signs were observed in either group.ConclusionYijinjing exercise may effectively enhance hand function, handgrip strength, and flexibility in RA patients with low disease activity. Furthermore, it appears to improve quality of life and reduce anxiety and depression without exacerbating joint inflammation.Clinical trial registrationhttps://clinicaltrials.gov/study/NCT05527158, Identifier NCT05527158.
Effect of intake of selected nutrients on skin firmness and elasticity in women
Authors: Podgórska Aleksandra , Kicman Aleksandra , Naliwajko Sylwia , Wacewicz-Muczyńska Marta , Niczyporuk Marek 
Published: November 2024

IntroductionThe proper functioning of the skin is influenced by a proper diet. The purpose of this study was to determine the effect of selected nutrients on selected skin parameters.MethodsThe study group included 59 women, who were divided into two age groups (under and over 40  years old). A three-day 24-h dietary interview was conducted among the study women and skin parameters were assessed using the Courage + Khazaka method.ResultsThe results showed LA, ALA, Dietary fiber, Na, K, Mg, Zn, Cu, Vitamin E, Thiamine, Riboflavin, Folates, Vitamins B6, B12 and C correlated with skin elasticity. On the other hand, skin elasticity is influenced exclusively by vitamin D acted on skin firmness.ConclusionThe results obtained indicate that a diet rich in appropriate nutrients has a positive effect on the proper maintenance of important skin parameters.