bluuebunny/crossref_metadata_2025_split huggingface dataset:
TFIIH localization is highly dynamic during zygotic genome activation in Drosophila, and its depletion causes catastrophic mitosis
Authors: Cruz-Becerra Grisel , Valerio-Cabrera Sarai , Juárez Mandy , Bucio-Mendez Alyeri , Zurita Mario 
Published: April 2018

ABSTRACT
In Drosophila, zygotic genome activation occurs in pre-blastoderm embryos during rapid mitotic divisions. How the transcription machinery is coordinated to achieve this goal in a very brief time span is still poorly understood. Transcription factor II H (TFIIH) is fundamental for transcription initiation by RNA polymerase II (RNAPII). Herein, we show the in vivo dynamics of TFIIH at the onset of transcription in Drosophila embryos. TFIIH shows an oscillatory behaviour between the nucleus and cytoplasm. TFIIH foci are observed from interphase to metaphase, and colocalize with those for RNAPII phosphorylated at serine 5 (RNAPIIS5P) at prophase, suggesting that transcription occurs during the first mitotic phases. Furthermore, embryos with defects in subunits of either the CAK or the core subcomplexes of TFIIH show catastrophic mitosis. Although, transcriptome analyses show altered expression of several maternal genes that participate in mitosis, the global level of RNAPIIS5P in TFIIH mutant embryos is similar to that in the wild type, therefore, a direct role for TFIIH in mitosis cannot be ruled out. These results provide important insights regarding the role of a basal transcription machinery component when the zygotic genome is activated.
Biological wound matrices with native dermis-like collagen efficiently modulate protease activity
Authors: Tati Ramesh , Nordin Sara , Abdillahi Suado M , Mörgelin Matthias 
Published: April 2018

Objective: When the delicate balance between catabolic and anabolic processes is disturbed for any reason, the healing process can stall, resulting in chronic wounds. In chronic wound pathophysiology, proteolytic imbalance is implicated due to elevated protease levels mediating tissue damage. Hence, it is important to design appropriate wound treatments able to control and modulate protease activity directly at the host/biomaterial interface. Here, we investigate collagen-based wound dressings with the focus on their potential to adsorb and inactivate tissue proteases. Method: We examined the effect of six collagen-based dressings on their ability to adsorb and inactivate different granulocyte proteases, plasmin, human neutrophil elastase (HLE), and matrix metalloproteases (MMP)-1, -2, -8, and -9, by an integrated approach including immunoelectron microscopy. Results: We observed a reduction of the proteolytic activities of plasmin, HLE, and MMP-1, -2, -8, and -9, both on the biomaterial surface and in human chronic wound fluid. The most pronounced effect was observed in collagen-based dressings, with the highest content of native collagen networks resembling dermis structures. Conclusion: Our data suggest that this treatment strategy might be beneficial for the chronic wound environment, with the potential to promote improved wound healing.
Distraction osteogenesis part 2: technical aspects
Authors: Barber Sophy , Carter Lachlan , Mannion Christopher , Bates Claire 
Published: April 2018

Abstract: The history and uses of Distraction Osteogenesis (DO) in the craniofacial region have previously been discussed. In this second part of the review the technical aspects of DO and the role of the different team members in the multidisciplinary care are described. The orthodontist is a key member of the team, assisting with treatment planning, pre-surgical orthodontics and the post-distraction phase. CPD/Clinical Relevance: This report provides a description of the technical aspects of distraction osteogenesis to enable orthodontists to understand the process and their role in the multidisciplinary team.
Feet in orthogonal-Buekenhout–Metz unitals
Authors: Abarzúa N. , Pomareda R. , Vega O. 
Published: April 2018

AbstractGiven an orthogonal-Buekenhout–Metz unitalUα,β, embedded in PG(2,q2), and a pointP∉Uα,β, we study the setτP(Uα,β) of feet ofPinUα,β. We characterize geometrically each of these sets as eitherq+ 1 collinear points or asq+ 1 points partitioned into two arcs. Other results about the geometry of these sets are also given.
Neural Mechanism and Representation of English and Chinese Metaphors of Bilinguals with Different Second Language Proficiency: An ERP Study
Authors: Wang Qian 
Published: April 2018

Abstract
Brain mechanism of metaphor processing has always been a focus in Neurolinguistics. This study approaches bilinguals’ metaphor semantic representation mechanism with Chinese bilinguals with different levels of second language proficiency by means of ERP (Event-related Potentials) technology. The experiment results showed that: 1) Both hemispheres collaborate in metaphor processing with the left hemisphere serving a leading semantic recognition role. The left hemisphere is more sensitive to first language input, while the right hemisphere is more active to second language input. 2) Compared with Chinese learners of higher proficiency in L2, learners of lower proficiency tend to adopt more Chinese neural mechanism in processing English metaphors. 3) When learners process metaphors, the neural mechanism difference of learners of higher proficiency is smaller than that of those of lower proficiency. The higher the second language proficiency, the higher the degree of common representation of Chinese and English metaphor.
“They Heard from a Distance”: The šemû-rūqu Paradigm in the Late Neo-Assyrian Empire
Authors: Richardson Seth 
Published: April 2018

Abstract
In its first 500 years, Assyrian imperial ideology was based on the idea that the empire was a monopole, a unique and ever-expanding core of order and right that continuously pushed back the borders of a disordered periphery, bringing new lands within the Assyrian state. Across these centuries, this precept resulted in virtually every encounter with other polities and peoples being described in terms of visuality and frontality: the enemy submitted on seeing the king, overwhelmed by his brilliant melammu, and bowed before him. By the late 9th century BC, however, the illusion of a monopolar world could no longer be sustained. Assyria began to come into (often second-hand) contact with numerous rival polities and peer states such as Phrygia, Kush, Dilmun, and Cyprus—places it did not, could not, and would never control. This new geopolitical paradigm formed a problem for Assyrian ideology, both conceptually and rhetorically, one that royal inscriptions attempted to solve through two new narrative tropes, often explicitly linked, about “distant” (rūqu) lands which were apprehensible through hearing (šemû) rather than seeing. As a historical matter, the hermeneutics of this rhetoric form a clear and demonstrable shift in literary style and topos in the last two centuries of the empire; but they further mark a change in mentalité, insofar as “the distant” emerged as a new ontological category of space which could not be integrated into the earlier imperial paradigm.
Impact of childhood type 1 diabetes on maternal work-family relations
Authors: Shalitin Shlomit , Hershtik Efrat , Phillip Moshe , Gavan Michal-Yackobovitz , Cinamon Rachel Gali 
Published: April 2018

Abstract

Background:
The aim of the study was to evaluate work-family conflict (WFC) and work-family facilitation (WFF) of working mothers of children with type 1 diabetes (T1D) compared with those of working mothers of children under follow-up not requiring treatment and of healthy children, and to explore the impact of organizational resources and the characteristics of the child and his disease on this interface.

Methods:
The study included 157 working mothers: 50 mothers of children with T1D, 50 mothers of children on medical follow-up without chronic illness and 57 mothers of healthy children. The participants completed validated questionnaires including the WFC scale, WFF scale, organizational resources support scale, life and work satisfaction questionnaire, a background demographic questionnaire and a child health questionnaire. Mothers of children with T1D also completed a questionnaire relating to diabetes management.

Results:
Almost half of the mothers of children with T1D found it necessary to reduce their working hours or to change their workplace. This group also reported a significantly higher level of colleague support. There were no significant differences in WFC and WFF between mothers of children with T1D and controls.

Conclusions:
This study demonstrates the effect of raising a T1D child on the mother’s vocational behavior. Despite the additional burden, work is a source of enrichment for these mothers.
Evaluation and implementation of the STA R Max® hemostaseology analyzer in the central laboratory of a major hospital
Authors: Hofmann Babette , Schröder Cathleen , Geisler Niels , Stamminger Gudrun 
Published: April 2018

Abstract
Due to a change of provider at Zentrum für Diagnostik at Klinikum Chemnitz a comprehensive validation of the STA R Max® analyser from Stago was undertaken. Alongside intra-assay and inter-assay determinations, a broad range of comparative measurements using pooled patient plasma were also carried out against the previous routine method (BCS XP from Siemens). Results obtained from routine and emergency sample testing are presented in this publication. Good to very good results were observed which allowed for a swift switchover in systems. Furthermore, user friendliness, reagents, turnaround times (TAT) and general susceptibilities of the new system were evaluated. After various adaptations to the diagnostic process, the transition to routine operation successfully took place.
Infections after renal transplantation
Authors: Dasdelen Süha , Grebe Scott-Oliver 
Published: April 2018

Abstract
Renal transplantation is the treatment-of-choice for a significant number of patients with end-stage renal disease. Prophylaxis, diagnosis and treatment of infections are cornerstones in the management of transplant patients. There are a number of opportunistic and rare pathogens in the immunosuppressed transplant patient population, whose early detection is essential for an optimized and targeted treatment. As the immunosuppressive regimen is adopted after transplantation and due to a potentially delayed reactivation of latent diseases, certain infections can occur in defined time intervals following transplantation. The present review summarizes the common and some of the rare diseases caused by the broad microbiological spectrum in kidney transplant recipients and the respective therapeutic options.
Environment Biological and Health Care Efforts Influenced of Lymfatic Filariasis Incidence, Sarmi Distric
Authors: Sipayung Mina , Wahjuni Chatarina Umbul , Devy Shrimarti 
Published: April 2018

ABSTRACTDistrict Sarmi is the most endemic area of filariasis in Papua which has rate of microfilaria (mf) (47.06%) up to the year2012. In the Province Papua filarial worm is Wuchereria bancrofti and is transmitted through the bite of a mosquito vectors. Lymphatic filariasis does not cause death, but in chronic cases it causes disability, psychosocial problems, stigma, and decreased productivity. This study was aimed to analyze environment biological and health care efforts that influence the incidence of lymphatic filariasis. This study used case-control method. Samples comprised 32 case samples (mf +) and 32 control samples (mf-). Primary data were collected through interviews and observation. Data were analyzed using Chi-Square and continued with multivariate Logistic Regression. Statistical analysis obtained indicated two variables on the incidence of lymphatic filariasis limfatik in District Sarmi (health care efforts pvalue = 0.002, OR: 7.779, as well as the biological environment pvalue= 0.008, OR: 5.841). Significant variables were health services with sub-variables promotion, prevention and the environmental biology. Suggestion: Mosquito bites should be avoided, the vector should be controlled through mutual cooperation and health promotion should be implemented.Keywords: Wuchereria bancrofti, lymphatic filariasis, vector, health care, Sarmi Distric
Rapid Assessment of Third Round of Sub PIN Diphteria at Tambakrejo Village Jombang
Authors: Ummamah Fatikhatul 
Published: April 2018

The third round of Sub PIN diphteria in Tambakrejo village has the lowest coverage and did not reach the target at age 2-36 months (61,77%) and age 3-7 years (82,39%). The aim of this study to describe more about implementation of third round of Sub PIN diphteria in November 2013. This study is descriptive research with Cross Sectional study design. Population is all of parents whose children’s ages 2 month to 15 years old when third round of Sub PIN diphteria are conducted in Kelurahan Tambakrejo. Samples on this research are 150 people were taken from two stages, the first stage is specifiying to 30 clusters (RT) and each cluster are taken 5 respondens. The variables examined in this study are immunization status, the reason not joining Sub PIN, source of information, characteristics of the respondents including age, educational level, occupation, number of children, parent’s knowledge and children’s age. The results showed that 26% of respondents did not covered by the third round of Sub PIN diphteria with the most reason is the children are not willing or crying (56,4%). If seen from respondents whose their children did not covered by the Sub PIN can be known most of them got information (92,3%) and characterictic of respondents most of them have age above 30 years old (66,7%), high level of education from SMA (61,5%), do not work (66,7%) with the number of children that they had 2 childs or under it (61,5%),high level of knowledge (76,9%), most of children’s age is 2 months up to 36 months (43,6%) and 7 years old up to 15 years old (43,6%). Concelling anda approach personally is needed by medics to inform about the benefits of Sub PIN and the danger if did not immunization especially to a pent whose child refuse immunized.Keywords : Rapid Assessment, SUB PIN, Diphteria
The Relationship between Knowledge, Sickness Period, and Intraocular Pressure to the Quality of Life of Glaucoma Patient
Authors: Ananda Efifta Pratama 
Published: April 2018

Eyes are an important sense because it has function to collect visual information, eyes can be in emergency condition if the function of sight got threatened. Glaucoma is the second causes of blindness after cataract which is permanent or irreversible. It can decrease the quality of life’s glaucomapatient. The purpose of this study is to reveal the relationship between knowledge, sickness period and intraocular pressure to the quality of life of glaucoma patient. This study is an analytical observation study which used sectional cross design study. The sample of this study were primary glaucoma patients and secondary glaucoma which have medical treatment in Rumah Sakit Mata Undaan Surabaya. The sample was choosen by systematic random sampling and the total number of sample are 68 peoples. The data have collected by having interview the glaucoma patients and seeing the medical records. To process the data, the writer used Chi Square analysis or Fisher Exact with 95% significance. The result of the study showed that there is a relationship between knowledge (p =0,033) and sickness period (p =0,035), while the intraocular pressure is not related to the quality of life’s of glaucoma patients in Rumah Sakit Mata Undaan Surabaya. The conclusion of this study is knowledge and sickness period have a relationship to the quality of life of glaucoma patients, while intraocular pressure is not related to the quality of life of glaucoma sufferers. The suggestion is to do early detection to people who have risk to get glaucoma and give an education about glaucoma disease to increase the quality of life of glaucoma sufferers. Keywords: The quality of life, glaucoma, knowledge, sickness period
Parameter Estimation from Sandface Drawdown Temperature Transient Data in the Presence of a Skin Zone Near the Wellbore
Authors: Panini Filippo , Onur Mustafa 
Published: April 2018

Abstract
The objectives of this study are to develop a new approximate analytical solution for predicting drawdown temperature transient behavior of a fully penetrating vertical well in a radial composite reservoir system and to use it as a forward model for estimating the fluid flow and thermal parameters of the system by nonlinear regression. The analytical solution considers a radial composite reservoir model, where the inner zone may represent a skin zone and the outer zone represents an infinitely extended reservoir. The analytical solution for predicting sandface temperatures is obtained by solving the decoupled isothermal diffusivity (pressure) and temperature equations for the inner and outer zones by using the Boltzmann transformation. The convection, transient adiabatic expansion and Joule-Thomson heating effects are all considered in solving the temperature equation. The developed analytical solution is validated by using both a commercial non-isothermal numerical simulator and a semianalytical solution available in the literature for different synthetic cases. For estimating the system parameters by history matching of observed temperature and/or pressure data with the model, we use the Levenberg-Marquardt method. We investigate the impact of noise in temperature and/or pressure data on the estimated parameters by inspecting statistical measures such as confidence intervals and correlation coefficients between parameter pairs. It is observed that selecting proper initial guesses of parameter is critical for estimating reliable values of the parameters through nonlinear regression of temperature data because the parameters are more correlated in the temperature equation than in pressure equation. Hence, we provide an effective methodology based on semi-log analysis and log-log diagnostic plots of pressure and temperature data to obtain good initial guesses of parameters that will derive the nonlinear regression method to have refined optimized estimates. The results show that the rock, fluid and thermal properties of the skin zone and non-skin zone can be reliably estimated from sandface temperature transient data jointly with pressure transient data in presence of noise, recorded during constant-rate drawdown tests with our approximate solutions and effective methodology proposed for obtaining initial guesses of the parameters.
Impact of Sulphates Presence During Application of Smart Water Flooding Combined with Polymer Flooding
Authors: Tahir Muhammad , Hincapie Rafael E. , Foedisch Hendrik , Abdullah Hiwa , Ganzer Leonhard 
Published: April 2018

Abstract
Oil recovery using Smart Water technology (SWF) can be maximized by optimizing the composition of injected water. Brine optimization is also believed to improve Polymer Flooding (PF) performance. The present study aims to assess and define the potential impact of combining Smart Water with Polymer Flooding, based on the sulphates presence in formation/injection water and rock composition. In this work, we study the impact of sulphates (sodium sulphates) on polymer viscoelasticity and its performance in porous media, based on oil recovery and pressure response.
Brine composition is optimized after having synthetic sea water (SSW) as a base brine. Brine optimization is performed by doubling the amount of sulphates, whilst diluting (in fresh water) the SSW-brine to a tenth of its initial concentration. Thus, four brines were utilized: 1) SSW (formation water), 2) SSW but double sulphates, 3) SSW/10 and 4) Brine 2/10. The workflow included core plugs aging prior core flooding. Secondary tertiary and quaternary mode experiments were performed to evaluate the feasibility of applying both processes.
The SSW-brine optimization (a tenth of its initial concentration) resulted in a salinity of 4.2 g/L which is in good agreement with previous studies (≤5 g/L), to guarantee additional oil recovery using SWF. Polymer rheological characterization was performed over wide range of shear rates and temperatures. Sodium sulphates showed increase in polymer viscosity as compare to sodium chloride or divalent cations. Enhancement in polymer linear viscoelasticity is observed with an increase in sulphate ions concentration. Furthermore, viscosity analysis over temperature has advocated to perform the core flood experiments at 45°C. Fluids were optimized/selected using a comprehensive rheological evaluation (ηoilηpolymer=2). Optimized Smart Water with higher amount of sulphates ions has shown additional oil recovery in both secondary and tertiary mode. Moreover, polymer injection in tertiary mode after smart water injection has shown significant additional oil recovery.
This study focuses on the influence of sulphates ions on SWF and PF performance for application in sandstone reservoirs. Previous studies have mainly focused the evaluation of sulphates ions impact only in carbonate reservoirs. It is of importance to further understand/clarify the effect of sulphates for field applications of SWF and PF combined. This in turn, could lead to improve the economics of project performance, by means of incremental oil and the less polymer required.
Integrated Dynamic Modelling of the Sea Lion Field
Authors: Lopez Marmolejo Aldo , Newbould Robert , Lawton Laura , Godlewski John 
Published: April 2018

Abstract
The Sea Lion Field is an Early Cretaceous turbidite fan complex, located in the North Falkland Basin, 220 km north of the Falkland Islands. The reservoirs are dominated by amalgamated high density turbidites (Bouma Ta and liquefied sediment gravity flows), but also contain low density turbidites, linked debrites and interdigitated lacustrine mudstones. An integrated dynamic modelling workflow which incorporates the latest understanding of the Sea Lion Field sedimentology and reservoir heterogeneities is presented.
The workflow focuses on capturing and retaining reservoir heterogeneity throughout the reservoir modelling process. Coarse-scale heterogeneity is captured during the construction of the full-field geological (static) model and conserved in the dynamic model by using the same grid dimensions. Sedimentological features (fine-scale heterogeneity) below the grid resolution are captured in separate, 3D core-scale models. Through a process of kv/kh and relative permeability upscaling, the core-scale models are used to inform effective permeability in the full-field model.
Detailed interpretation of the available core data enables a statistical evaluation, which underpins the construction of core-scale models for the individual rock types. The resulting 3D core-scale models are representative of the reservoir and the development concept in terms of reservoir dip, lithology, petrophysical and fluid properties and well spacing. Matching the coarse model behaviour to the core-scale model forecast is an inverse problem with multiple possible solutions; therefore, assisted history matching is a valuable tool for quickly obtaining, comparing and ranking possible upscaled relative permeability functions and kv/kh ratios. The upscaled relative permeability functions output from the assisted history matching workflow correct for numerical dispersion and reproduce the waterflood behaviour observed in the core-scale model, thus capturing the influence of small-scale heterogeneities.
This integrated dynamic modelling workflow allows for the direct use of detailed geological models characterising the main heterogeneities impacting flow behaviour, while retaining the ability to investigate and capture small-scale heterogeneities below the resolution of the full-field static model, thus avoiding the cumbersome process of upscaling geological properties. Assisted history matching and optimization have been integrated into the workflow, providing a robust method to produce upscaled relative permeability functions that replicate the expected waterflood behaviour.