bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative analysis identifies lincRNAs up- and downstream of neuroblastoma driver genes
Authors: Rombaut Dries , Chiu Hua-Sheng , Decaesteker Bieke , Everaert Celine , Yigit Nurten , Peltier Agathe , Janoueix-Lerosey Isabelle , Bartenhagen Christoph , Fischer Matthias , Roberts Stephen , D’Haene Nicky , De Preter Katleen , Speleman Frank , Denecker Geertrui , Sumazin Pavel , Vandesompele Jo , Lefever Steve , Mestdagh Pieter 
Published: April 2019

AbstractLong intergenic non-coding RNAs (lincRNAs) are emerging as integral components of signaling pathways in various cancer types. In neuroblastoma, only a handful of lincRNAs are known as upstream regulators or downstream effectors of oncogenes. Here, we exploit RNA sequencing data of primary neuroblastoma tumors, neuroblast precursor cells, neuroblastoma cell lines and various cellular perturbation model systems to define the neuroblastoma lincRNome and map lincRNAs up- and downstream of neuroblastoma driver genesMYCN,ALKandPHOX2B. Each of these driver genes controls the expression of a particular subset of lincRNAs, several of which are associated with poor survival and are differentially expressed in neuroblastoma tumors compared to neuroblasts. By integrating RNA sequencing data from both primary tumor tissue and cancer cell lines, we demonstrate that several of these lincRNAs are expressed in stromal cells. Deconvolution of primary tumor gene expression data revealed a strong association between stromal cell composition and driver gene status, resulting in differential expression of these lincRNAs. We also explored lincRNAs that putatively act upstream of neuroblastoma driver genes, either as presumed modulators of driver gene activity, or as modulators of effectors regulating driver gene expression. This analysis revealed strong associations between the neuroblastoma lincRNAsMIATandMEG3andMYCNandPHOX2Bactivity or expression. Together, our results provide a comprehensive catalogue of the neuroblastoma lincRNome, highlighting lincRNAs up- and downstream of key neuroblastoma driver genes. This catalogue forms a solid basis for further functional validation of candidate neuroblastoma lincRNAs.
Age-Related Differences in the Late Positive Potential during Emotion Regulation between Adolescents and Adults
Authors: Deng Xinmei , Sang Biao , Ku Yixuan , Sai Liyang 
Published: April 2019

AbstractThe late positive potential (LPP) has been well documented in predicting the effect of emotion regulation in previous developmental literature. However, few studies have examined age-related changes in emotion regulation from adolescence to adulthood using this biomarker. To test this, Reactivity and Regulation-Image Task was used to test 18 young adolescents and 22 adults to examine the modulation of LPP during emotion regulation. Results revealed that (a) on the behavioral level, adults reported higher intensity of emotional experience than adolescents when they were asked to use up-regulation. Down-regulation showed no age effect for self-reported rating; (b) adolescents showed higher amplitudes of LPP than adults when using different regulatory strategies in all windows; (c) In late time window, regulation effect was larger when using up-regulation strategy than down-regulation strategy for adolescents, while the difference between the two strategies was negligible for adults. (d) In early time window, reactivity effect was larger in negative conditions than in positive conditions for adolescents, while the difference between the two conditions was again negligible for adults. Differences in the amplitudes and time courses of LPP during emotion regulation between adolescents and adults suggested that age-related changes in emotion regulation may occur during adolescence.
Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection
Authors: Macchione Micaela A. , Guerrero-Beltrán Carlos , Rosso Anabella P. , Euti Esteban M. , Martinelli Marisa , Strumia Miriam C. , Muñoz-Fernández Maria Ángeles 
Published: April 2019

AbstractStimuli-responsive nanogels offer promising perspectives for the development of next generation formulations for biomedical applications. In this work, poly(N-vinylcaprolactam) nanogels were synthesized varying the concentration of monomer and crosslinking agent. Thus, the inhibitory effect of poly(N-vinylcaprolactam) nanogels against HIV-1 infection is presented for the first time. In particular, we have demonstrated that one of the synthesized poly(N-vinylcaprolactam) nanogels with initial concentration of 80 mg of vinylcaprolactam and 4% of crosslinking agent shows antiviral behavior against HIV-1 infection since this nanogel inhibits the viral replication in TZM.bl target cells.
Microwear and isotopic analyses on cave bear remains from Toll Cave reveal both short-term and long-term dietary habits
Authors: Ramírez-Pedraza Iván , Tornero Carlos , Pappa Spyridoula , Talamo Sahra , Salazar-García Domingo C. , Blasco Ruth , Rosell Jordi , Rivals Florent 
Published: April 2019

AbstractDietary habits of the extinct Ursus spelaeus have always been a controversial topic in paleontological studies. In this work, we investigate carbon and nitrogen values in the bone collagen and dental microwear of U. spelaeus specimens recovered in Level 4 from Toll Cave (Moià, Catalonia, NE Iberian Peninsula). These remains have been dated to > 49,000 14C BP. The ability of both proxies to provide data on the diet of U. spelaeus at different times in the life-history (isotopes: average diet of life; microwear: last days/weeks before death), allows us to generate high-resolution and complementary data. Our results show lower values (δ13C & δ15N) in cave bears than in strict herbivores (i.e. Cervus elaphus) recovered from the same level of Toll Cave. On the other hand, 12 lower molars (m1) were analysed through low-magnification microwear technique. The cave bears from Toll Cave show a microwear pattern like that of extant bears with omnivorous and carnivorous diets. These data are discussed in the framework of all available data in Europe and add new information about the plasticity of the dietary habits of this species at the southern latitudes of Europe during Late Pleistocene periods.
Mechanism of subsidence of the Northeast Japan forearc during the late period of a gigantic earthquake cycle
Authors: Sasajima Ryohei , Shibazaki Bunichiro , Iwamori Hikaru , Nishimura Takuya , Nakai Yoshihiko 
Published: April 2019

AbstractThe forearc in Northeast Japan subsided (3–4 mm/year) in the interseismic ~100 years before the 2011 Tohoku earthquake (MW9.1) just like it did during this event. This study attempts to understand the mechanism of the vertical displacement of the forearc during gigantic earthquake cycles via numerical modeling. The results suggest that the interseismic subsidence rate in the forearc increases with the duration of the locking of the asperity of the gigantic earthquake over several hundred years, due to the increasing slip deficit rate on the deeper parts of the plate interface. The increasing slip deficit rate is caused by both the decreasing the shear stress in the shear zone owing to the continuous locking of the asperity and the increasing the mobility of the continental lithosphere owing to the viscoelastic relaxation in the mantle wedge. The deep slip deficit rate extending to ~100 km depth of the plate interface is necessary to explain the observed interseismic forearc subsidence rate. The results also suggest hundreds of years of continuous locking of the asperities of a gigantic earthquake in the western Kuril subduction zone, where fast forearc subsidence has been observed as well.
Effect of prey size and structural complexity on the functional response in a nematode- nematode system
Authors: Kreuzinger-Janik Bianca , Brüchner- Hüttemann Henrike , Traunspurger Walter 
Published: April 2019

AbstractThe functional response of a predatory nematode and the influence of different prey sizes and habitat structure on the concerning parameters were analyzed. We hypothesized that the handling of small prey would be less time-consuming, whereas feeding on larger prey would be more efficient. Therefore, type II functional response curves were expected for large prey and a trend towards type III curves for small prey. We expected the introduction of prey refuges to shift the functional response curves from hyperbolic to sigmoidal and that the effect would be even more pronounced with smaller prey.P. muscorumconsumed large amounts of small and largeC. elegans, with dailyper capitaingestion of prey reaching a maximum of 19.8 µg fresh weight, which corresponds to 4.8 times the predator’s biomass. Regardless of prey size and habitat structure,P. muscorumexhibit a type III functional response. Overall, the allometric effect of prey size had a greater effect on the predator’s functional response than did the addition of substrate, presumably due to the similar body shape and mobility of the two nematode species. Our results demonstrate that individual factors such as feeding behavior are important determinants of functional responses and therefore of ecosystem stability.
Optimal blood pressure after reperfusion therapy in patients with acute ischemic stroke
Authors: Choi Kang-Ho , Kim Jae-Myung , Kim Ja-Hae , Kim Joon-Tae , Park Man-Seok , Choi Seong-Min , Lee Seung-Han , Kim Byeong C. , Kim Myeong-Kyu , Cho Ki-Hyun 
Published: April 2019

AbstractWe investigated the relationship between the mean blood pressure (BP) at 24–72 h and the clinical outcomes after acute ischemic stroke (AIS) in patients treated with reperfusion therapy. The primary outcome was measured using the modified Rankin Scale (mRS) at 3 months after AIS, and was based on the mean systolic BP at 24–72 h post-AIS. Favorable outcome was defined as mRS scores of 0–2. A total of 1,540 patients treated with reperfusion therapy were enrolled in the study. Favorable outcomes occurred more frequently in patients with BP ≤ 130/80 mmHg, and the risks of symptomatic intracranial hemorrhage and early neurological deterioration were lower in this optimal BP group. Multivariable analysis showed a significant association between mean BP ≤ 130/80 mmHg at 24–72 h and favorable outcomes at 3 months after AIS (odds ratio 2.95, 95% confidence interval 2.32–3.77, p < 0.001). Prespecified subgroup analyses showed that BP ≤ 130/80 mmHg had a more significant impact on clinical outcome in patients with recanalization than in those without recanalization. These data indicate that a mean BP of ≤ 130/80 mmHg at 24–72 h post-AIS is independently associated with favorable outcomes in patients treated with reperfusion therapy, particularly in those with recanalization.
Analysis of fibrosis in control or pressure overloaded rat hearts after mechanical unloading by heterotopic heart transplantation
Authors: Schaefer Andreas , Schneeberger Yvonne , Schulz Steven , Krasemann Susanne , Werner Tessa , Piasecki Angelika , Höppner Grit , Müller Christian , Morhenn Karoline , Lorenz Kristina , Wieczorek David , Schwoerer Alexander P. , Eschenhagen Thomas , Ehmke Heimo , Reichenspurner Hermann , Stenzig Justus , Cuello Friederike 
Published: April 2019

AbstractMechanical unloading (MU) by implantation of left ventricular assist devices (LVAD) has become clinical routine. This procedure has been shown to reverse cardiac pathological remodeling, with the underlying molecular mechanisms incompletely understood. Most studies thus far were performed in non-standardized human specimens or MU of healthy animal hearts. Our study investigates cardiac remodeling processes in sham-operated healthy rat hearts and in hearts subjected to standardized pathological pressure overload by transverse aortic constriction (TAC) prior to MU by heterotopic heart transplantation (hHTx/MU). Rats underwent sham or TAC surgery. Disease progression was monitored by echocardiography prior to MU by hHTx/MU. Hearts after TAC or TAC combined with hHTx/MU were removed and analyzed by histology, western immunoblot and gene expression analysis. TAC surgery resulted in cardiac hypertrophy and impaired cardiac function. TAC hearts revealed significantly increased cardiac myocyte diameter and mild fibrosis. Expression of hypertrophy associated genes after TAC was higher compared to hearts after hHTx/MU. While cardiac myocyte cell diameter regressed to the level of sham-operated controls in all hearts subjected to hHTx/MU, fibrotic remodeling was significantly exacerbated. Transcription of pro-fibrotic and apoptosis-related genes was markedly augmented in all hearts after hHTx/MU. Sarcomeric proteins involved in excitation-contraction coupling displayed significantly lower phosphorylation levels after TAC and significantly reduced total protein levels after hHTx/MU. Development of myocardial fibrosis, cardiac myocyte atrophy and loss of sarcomeric proteins was observed in all hearts that underwent hHTX/MU regardless of the disease state. These results may help to explain the clinical experience with low rates of LVAD removal due to lack of myocardial recovery.
An application of (4YSZ)0.93(Fe2O3)0.07 in limiting current oxygen sensor
Authors: Wang Xiangnan , Liu Tao , Yu Jingkun 
Published: April 2019

Abstract(4YSZ)0.93(Fe2O3)0.07 and 9 mol% Y2O3 stabilized ZrO2 (9YSZ) were synthesized by co-precipitation method and their crystalline structure, microstructure, electronic conductivity, total conductivity were characterized. A limiting current oxygen sensor was assembled with (4YSZ)0.93(Fe2O3)0.07 dense diffusion barrier and 9YSZ solid electrolyte by Pt sintered-paste method. Influences of temperature (T), oxygen concentration (x(O2)) and water vapor pressure (p(H2O)) on sensing characteristics of the limiting current oxygen sensor were investigated. The crystalline structure of (4YSZ)0.93(Fe2O3)0.07 and 9YSZ belong to cubic structure with $${\bf{Fm}}\overline{{\bf{3}}}{\bf{m}}$$
Fm

3

¯

m
. The total conductivity of (4YSZ)0.93(Fe2O3)0.07 is higher than that of 9YSZ and the electronic and total conductivities of the samples meet the linear relationship with 1000/T. The limiting current oxygen sensor exhibits excellent sensing characteristics under test conditions. The effects of T, x(O2) and p(H2O) are as follows: Log(IL·T) depends linearly on 1000/T, IL depends linearly on x(O2) and IL is not significantly dependent on p(H2O).
Glutaminolysis and lipoproteins are key factors in late immune recovery in successfully treated HIV-infected patients
Authors: Rosado-Sánchez Isaac , Rodríguez-Gallego Esther , Peraire Joaquim , Viladés Consuelo , Herrero Pol , Fanjul Fran , Gutiérrez Félix , Bernal Enrique , Pelazas Ricardo , Leal Manuel , Veloso Sergi , López-Dupla Miguel , Blanco Julià , Vidal Francesc , Pacheco Yolanda María , Rull Anna 
Published: April 2019

Abstract
The immunological, biochemical and molecular mechanisms associated with poor immune recovery are far from known, and metabolomic profiling offers additional value to traditional soluble markers. Here, we present novel and relevant data that could contribute to better understanding of the molecular mechanisms preceding a discordant response and HIV progression under suppressive combined antiretroviral therapy (cART). Integrated data from nuclear magnetic resonance (NMR)-based lipoprotein profiles, mass spectrometry (MS)-based metabolomics and soluble plasma biomarkers help to build prognostic and immunological progression tools that enable the differentiation of HIV-infected subjects based on their immune recovery status after 96 weeks of suppressive cART. The metabolomic signature of ART-naïve HIV subjects with a subsequent late immune recovery is the expression of pro-inflammatory molecules and glutaminolysis, which is likely related to elevate T-cell turnover in these patients. The knowledge about how these metabolic pathways are interconnected and regulated provides new targets for future therapeutic interventions not only in HIV infection but also in other metabolic disorders such as human cancers where glutaminolysis is the alternative pathway for energy production in tumor cells to meet their requirement of rapid proliferation.
Spectrophotometric variegation of the layering in comet 67P/Churyumov-Gerasimenko as seen by OSIRIS
Authors: Tognon G. , Ferrari S. , Penasa L. , La Forgia F. , Massironi M. , Naletto G. , Lazzarin M. , Cambianica P. , Lucchetti A. , Pajola M. , Ferri F. , Güttler C. , Davidsson B. , Deshapriya P. , Fornasier S. , Mottola S. , Tóth I. , Sierks H. , Lamy P. L. , Rodrigo R. , Koschny D. , Barbieri C. , Barucci M. A. , Bertaux J.-L. , Bertini I. , Bodewits D. , Cremonese G. , Da Deppo V. , Debei S. , De Cecco M. , Deller J. , Franceschi M. , Frattin E. , Fulle M. , Gutiérrez P. J. , Ip W.-H. , Keller H. U. , Lara L. M. , López-Moreno J. J. , Marzari F. , Petropoulou V. , Shi X. , Tubiana C. 
Published: April 2019

Context.Between August 2014 and September 2016, the ESA space mission Rosetta escorted comet 67P/Churyumov-Gerasimenko (67P) during its perihelion passage. The onboard OSIRIS Narrow Angle Camera (NAC) acquired high-resolution multispectral images of the cometary surface. These datasets allowed a characterization of the spectrophotometric variegation of the layering of the large lobe, correlated with the layer structural elevation.Aims.We perform a spectrophotometric characterization of the outcropping stratification of the small lobe of 67P as a function of its structural elevation, and consequently, a spectrophotometric comparison of the layered outcrops of the two lobes.Methods.We selected two sequences of post-perihelion OSIRIS NAC images (~2.4 au outbound tothe Sun), from which we built up two multispectral images, framing an extended geological section of the onion-like stratification of the small lobe. Then we classified the consolidated areas of the outcropping and the relative coarse deposits that were identified in the multispectral data with a two-class maximum likelihood method. For this, we defined the classes as a function of the structural elevation of the surface.Results.As a result, we identified a brightness variegation of the surface reflectance that is correlated with the structural elevation. The outer class, which is located at higher elevations, appears darker than the inner class. This fits previously obtained results for the large lobe. The reflectance values of the nucleus of 67P tend to decrease with increasing structural elevation.Conclusions.The observed spectrophotometric variegation can be due to a different texture as well as to a different content of volatiles and refractories. We suggest that the outer outcrops appear darker because they have been exposed longer, and the inner outcrops appear brighter because the surface has been more effectively rejuvenated. We interpret this variegation as the result of an evolutionary process.
News through a social media filter
Authors: Welbers Kasper , Opgenhaffen Michaël 
Published: April 2019

Abstract
Social media have become important news sources, prompting news organizations to create social media accounts to publish news. This requires a medium-based translation, in which social media editors must remediate news – selecting and possibly re-interpreting content – to accommodate a different audience and format. In this study we investigate this remediation for the issue of immigration, comparing the news coverage of immigration on the website and Facebook page of various newspapers using a novel method, which combines qualitative interpretation with computational text analysis. As a result, we can study the news coverage of immigration of five newspapers over two years, and substantiate our observations with quantitative, empirical results. Our findings show that while the overall portrayal of immigration is largely similar, there are some differences that could prove to be important and require further elaboration.
Lexical aspects of comprehensibility and nativeness from the perspective of native-speaking English raters
Authors: Appel Randy , Trofimovich Pavel , Saito Kazuya , Isaacs Talia , Webb Stuart 
Published: April 2019

Abstract
This study analyzed the contribution of lexical factors to native-speaking raters’ assessments of comprehensibility and nativeness in second language (L2) speech. Using transcribed samples to reduce non-lexical sources of bias, 10 naïve L1 English raters evaluated speech samples from 97 L2 English learners across two tasks (picture description and TOEFL integrated). Subsequently, the 194 transcripts were analyzed through statistical software (e.g., Coh-metrix, VocabProfile) for 29 variables spanning various lexical dimensions. For the picture description task, separation in lexical correlates of the two constructs was found, with distinct lexical measures tied to comprehensibility and nativeness. In the TOEFL integrated task, comprehensibility and nativeness were largely indistinguishable, with identical sets of lexical variables, covering dimensions of diversity and range. Findings are discussed in relation to the acquisition, assessment, and teaching of lexical properties in L2 speech.
Red train, big train, broken train
Authors: Weicker Merle , Schulz Petra 
Published: April 2019

This paper investigates the role of formal semantic properties in the acquisition of adjectives. Based on these semantic properties we propose an implicational Semantic Feature Hierarchy, which postulates that the order of emergence is determined by the adjectives’ semantic complexity. To test this hierarchy a high density corpus of spontaneous speech (age 2;00–2;11 years) was analyzed regarding the adjectives’ entailment and gradability properties. The data are in line with our hypothesis that the emergence of adjective classes is based on formal semantic criteria. Moreover, our data analyses show that semantic complexity is not mirrored in type frequency. Regarding the syntactic distribution of adjectives in child language we found that as soon as adjectives and nouns are combined, attributive structures are preferred over predicative structures.
Argument omission in SignL2 acquisition by deaf learners
Authors: Koulidobrova Elena V. 
Published: April 2019

We examine subject omission in American Sign Language (ASL) as a second sign language (SignL2) by deaf and hard-of-hearing users of Emirati Sign Language (EmiratiSL) with variable ages of exposure to SignL1. Results indicate that during a narrative, similarly to unimodal speech bilinguals, SignL2 learners of low ASL proficiency oversupply overt subject arguments – both NPs and pronouns (IX). In this, SignL2 learners behave differently from other ASL bilinguals described in the literature. We interpret the findings as offering support to the line of research arguing that certain atypicalities in multilingual production are best explained as resulting from the interaction between linguistic and general cognitive control mechanisms – i.e. that bilinguals oversupply arguments due to processing reasons. This phenomenon is modality independent.