bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activity-Based Ratiometric FRET Probe Reveals Oncogene-Driven Changes in Labile Copper Pools Induced by Altered Glutathione Metabolism
Authors: Chung Clive Yik-Sham , Posimo Jessica M. , Lee Sumin , Tsang Tiffany , Davis Julianne M. , Brady Donita C. , Chang Christopher J. 
Published: June 2019

AbstractCopper is essential for life, and beyond its well-established ability to serve as a tightly-bound, redox-active active site cofactor for enzyme function, emerging data suggest that cellular copper also exists in labile pools, defined as loosely bound to low molecular weight ligands, which can regulate diverse transition metal signaling processes spanning neural communication and olfaction, lipolysis, rest-activity cycles, and kinase pathways critical for oncogenic signaling. To help decipher this growing biology, we report a first-generation ratiometric fluorescence resonance energy transfer (FRET) copper probe, FCP-1, for activity-based sensing of labile Cu(I) pools in live cells. FCP-1 links fluorescein and rhodamine dyes through a tris[(2-pyridyl)methyl]amine (TPA) bridge. Bioinspired Cu(I)-induced oxidative cleavage decreases FRET between fluorescein donor and rhodamine acceptor. FCP-1 responds to Cu(I) with high metal selectivity and oxidation-state specificity and facilitates ratiometric measurements that minimize potential interferences arising from variations in sample thickness, dye concentration, and light intensity. FCP-1 enables imaging of dynamic changes in labile Cu(I) pools in live cells in response to copper supplementation/depletion, differential expression of the copper importer CTR1, and redox stress induced by manipulating intracellular glutathione levels and GSH/GSSG ratios. FCP-1 imaging reveals a labile Cu(I) deficiency induced by oncogene-driven cellular transformation that promotes fluctuations in glutathione metabolism, where lower GSH/GSSG ratios decrease labile Cu(I) availability without affecting total copper levels. By connecting copper dysregulation and glutathione stress in cancer, this work provides a valuable starting point to study broader crosstalk between metal and redox pathways in health and disease with activity-based probes.SignificanceCopper is a required metal nutrient for life, yet its altered homeostasis is associated with many diseases. Thus, to develop new methods to help decipher copper biology, we present an activity-based ratiometric FRET probe that exploits a biomimetic, copper(I)-dependent cleavage reaction to enable imaging of loosely-bound, labile copper pools in cells with metal and oxidation state selectivity and a self-calibrating ratiometric response. Application of this technology to cellular models of cancer reveals that oncogene-driven changes in the metabolism of glutathione, a major cellular redox buffer, leads to a labile copper(I) deficiency. This work establishes the relevance of copper dysregulation to cancer metabolism and presages further opportunities for activity-based sensing in studies of metal biology.
GLIDARC reactor power supply with ignition improvement
Authors: Krupski Piotr , Stryczewska Henryka Danuta 
Published: June 2019

Purpose
The research purpose of this paper is to confirm that internal overvoltages in the push–pull power inverter can be used to improve the discharge ignition in the gliding arc discharge (GAD) plasma reactor.

Design/methodology/approach
Investigations are based on the acquisition of voltage changes that occur together with the development of the discharge column and the imaging the GAD with the use of a high-speed camera.

Findings
The power supply has the distinctive feature of not having the switching overvoltages completely extinguished, as it is in typical push–pull inverters. The overvoltages still exist but only dangerous peaks are cut off. The remaining ones, of a dumped resonance character (Figure 3), are transferred to the secondary coil of the transformer. Correctly shaped overvoltages are used for ignition improvement in the GAD reactor.

Practical implications
GAD plasma reactors have many applications for pollution control, disinfection and sterilization of surfaces and for plasma deposition, surface functionalization, as well as in agricultural and medical treatment. Investigations prove the push–pull inverter’s advantages in comparison with the transformer-type power supply. Properly configured push–pull inverters have good ignition properties and control options, allowing to generate, desirable for many applications, homogeneous non-thermal plasma.

Originality/value
The idea of using switching overvoltages in transistors of push–pull switching-mode power supplies is new and has not been previously used to improve discharges ignition in a non-thermal plasma reactor.
Brand authenticity leads to perceived value and brand trust
Authors: Hernandez-Fernandez Asuncion , Lewis Mathieu Collin 
Published: June 2019

Purpose
This paper investigates consumer perceptions of brand authenticity (BA), perceived value (PV) and brand trust (BT) into the context of craft beer market. The purpose of this paper is to examine the statistical associations between these constructs as well as the three antecedents of BA: individuality, consistency and continuity.

Design/methodology/approach
The survey, delivered in an online format, was completed by 749 respondents from the USA. These respondents were gained through a basic simple random sampling technique. After conducting data analysis techniques such as reliability, correlation and regression, all five research hypotheses were accepted.

Findings
All three antecedents of BA were found to have significant influence on the first-order construct. Also, BA was shown to have a substantial effect on both PV and BT. The relationship between brand individuality and BA was the most significant of the five, while the association between BA and PV was found to be the least significant.

Originality/value
Prior research on BA, the majority of which has involved a qualitative approach, has been severely limited. The authors’ work deepens the study of the effects of BA, or its various antecedents, on PV and BT, enhancing the research with an empirical, quantitative analysis. In addition to the shortage of investigation related to these factors, there has been a nearly complete absence of the application of these variables to the craft beer market.
An extended time-dependent KdV6 equation
Authors: Wazwaz Abdul-Majid , Xu Gui-Qiong 
Published: June 2019

Purpose
The purpose of this paper is to develop a new time-dependent KdV6 equation. The authors derive multiple soliton solutions and multiple complex soliton solutions for a time-dependent equation.

Design/methodology/approach
The newly developed time-dependent model has been handled by using the Hirota’s direct method. The authors also use the complex Hirota’s criteria for deriving multiple complex soliton solutions.

Findings
The examined extension of the KdV6 model exhibits complete integrability for any analytic time-dependent coefficient.

Research limitations/implications
The paper presents a new efficient algorithm for constructing extended models which give a variety of multiple real and complex soliton solutions.

Practical implications
The paper introduced a new time-dependent KdV6 equation, where integrability is emphasized for any analytic time-dependent function.

Social implications
The findings are new and promising. Multiple real and multiple complex soliton solutions were formally derived.

Originality/value
This is an entirely new work where a new time-dependent KdV6 equation is established. This is the first time that the KdV6 equation is examined as a time-dependent equation. Moreover, the complete integrability of this newly developed equation is emphasized via using Painlevé test.
Investigating the influences of pressure-equalizing grooves on characteristics of aerostatic bearings based on CFD
Authors: Yan Ruzhong , Wang Liaoyuan , Wang Shengze 
Published: June 2019

Purpose
The purpose of this study is to reveal the influence law of pressure-equalizing grooves on aerostatic bearings and improve the static performance of bearings by optimizing the distribution form of grooves.

Design/methodology/approach
In view of two kinds of common restrictor distribution forms on the thrust surface, the linear and the rectangular, six kinds of pressure-equalizing groove schemes were proposed – the line-shape, the extended-shape, the S-shape, the oblong-shape, the X-shape and the reticular-shape. Based on the analysis of lubrication theory of the orifice-type aerostatic bearing, the numerical simulations of different bearings were carried out. The pressure distributions and static characteristic curves of different bearings were obtained.

Findings
The study reveals that the adoption of the pressure-equalizing grooves can substantially improve the load capacity and static stiffness of the bearing and make the bearing maintain a uniform stress, which enhances operating accuracy and life of the bearing. The superior function of the reticular-shape groove is highlighted.

Originality/value
The research results can effectively guide the optimization design of aerostatic bearings and provide a crucial technical reference for application of ultra-precision aerostatic supporting system.
Access to finance and entrepreneurial intention
Authors: Urban Boris , Ratsimanetrimanana Fenosoa 
Published: June 2019

PurposeAppreciating the need to foster entrepreneurship in Madagascan rural areas and acknowledging that many unanswered questions remain regards testing the theory of planned behaviour (TPB), the study aims to apply and extend the TPB model by investigating the moderating effect of access to finance (A2F) on entrepreneurial intentions (EI).DesignBased on survey data (n = 1,456) collected across several regions in Madagascar, hypotheses are statically tested using regression analyses.FindingsA significant moderating effect is revealed on the TPB-EI relationship in terms of attitude towards behaviour and perceived behavioural control. Moreover, levels of education and gender differences also influence this relationship.Research limitations/implicationsPolicy directives for the Madagascan Government and other private institutions include fostering support systems for those who intend to enter into entrepreneurship. On a practical level, Malagasy policymakers and decision makers at financial institutions need to pay particular attention to the TPB antecedents.OriginalityThe paper makes a contribution to the literature by providing empirical evidence on the moderating role of A2F on the TPB-EI link, while also explaining how individual-level variables influence this relationship in an under-researched developing country context – Madagascar.
PROMETHEE-based ranking of project managers based on the five personality traits
Authors: Aretoulis Georgios N. , Papathanasiou Jason , Antoniou Fani 
Published: June 2019

Purpose
This paper aims to rank and identify the most efficient project managers (PMs) based on personality traits, using Preference Ranking Organization METHod for Enrichment Evaluations (PROMETHEE) methodology.

Design/methodology/approach
The proposed methodology relies on the five personality traits. These were used as the selection criteria. A questionnaire survey among 82 experienced engineers was used to estimate the required weights per personality trait. A second two-part questionnaire survey aimed at recording the PMs profile and assess the performance of personality traits per PM. PMs with the most years of experience are selected to be ranked through Visual PROMETHEE.

Findings
The findings suggest that a competent PM is the one that scores low on the “Neuroticism” trait and high especially on the “Conscientiousness” trait.

Research limitations/implications
The research applied a psychometric test specifically designed for Greek people. Furthermore, the proposed methodology is based on the personality characteristics to rank the PMs and does not consider the technical skills. Furthermore, the type of project is not considered in the process of ranking PMs.

Practical implications
The findings could contribute in the selection of the best PM that maximizes the project team’s performance.

Social implications
Improved project team communication and collaboration leading to improved project performance through better communication and collaboration. This is an additional benefit for the society, especially in the delivery of public infrastructure projects. A lot of public infrastructure projects deviate largely as far as cost and schedule is concerned and this is an additional burden for public and society. Proper project management through efficient PMs would save people’s money and time.

Originality/value
Identification of the best PMbased on a combination of multicriteria decision-making and psychometric tests, which focus on personality traits.
Islamist parties and social movements: cases of Egypt and Tunisia
Authors: Medhat Abdelkader Nora 
Published: June 2019

Purpose
This paper aims to shed light on the previous ideological stands of the newly established Islamist parties in terms of the idea of party formation, and different models of their relations with the social movements from which they emanated through focusing on some case studies, namely, Egypt and Tunisia, with an attempt to study their impact on the parties’ paths by concentrating on two dimensions: the decision-making process and alliances’ building.

Design/methodology/approach
The paper is written according to the comparative case studies approach and Huntington’s new institutionalism.

Findings
The research findings proved that, in the light of the two case studies, there are two different models of relations exist between the Islamist political parties and the social movements they emanated from, and despite that both parties had come out from social movements or took the form of a movement in their beginnings and were established within the same context, they showed different perspectives in dealing later on with the new institutional and political context and their rising challenges. These perspectives affected the parties’ decision-making process and alliances’ building, as well as their institutional legitimacy and determined their political future.

Originality/value
In the end, this paper attempts to deal with the degree of institutionalization these parties enjoyed, based on how the movements they emanated from had dealt with the dilemma of party building and the party-movement relations.
Should social enterprises complement or supplement public health provision?
Authors: Poveda Sammia , Gill Melinda , Junio Don Rodney , Thinyane Hannah , Catan Vanessa 
Published: June 2019

Purpose
This paper aims to explore how stable employment, company culture and tailored health, digital and core skills training provided by a social enterprise (SE) in the Philippines affect survivors of exploitation. Research shows survivors experience adverse social conditions and physical and mental health outcomes caused by their exploitative experience. Stable, decent employment has been identified as critical to their recovery and reintegration. This paper discusses the SE’s impact on the employees’ physical, mental and social health and behaviour. Based on our findings, the authors discuss the contribution of SE in improving health outcomes and providing health services and conclude that SEs should not replace but complement public health government programmes.

Design/methodology/approach
This paper uses mixed methods, presenting data from a longitudinal survey (household income, mental health and social well-being) and a follow-up qualitative study, which uses in-depth interviews and participatory videos to explore survey findings.

Findings
The quantitative analysis demonstrates positive, but gradual, changes in sexual and reproductive health behaviour; personal empowerment; and trauma, anxiety and depressive symptoms. The qualitative findings show how improvements in executive functioning, self-regulation and self-esteem occur incrementally over time. As their self-efficacy improves, employees need to avoid being overly dependent on the SE, to support their autonomy; therefore, access to complementary public health services is fundamental.

Originality/value
This paper focusses, to the authors’ knowledge, on a unique SE, which hires survivors of exploitation, without losing their competitiveness in the market.
Janus kinase inhibitors: An innovative treatment for alopecia areata
Authors: Park Hyunsun , Yu Da‐Ae , Kwon Ohsang 
Published: June 2019

AbstractAlopecia areata (AA) is a relatively common disease, but no satisfactory treatment has yet been developed. Recently, research progress has been made in the pathogenesis of AA, revealing that autoreactive cytotoxic T cells are important and that the Janus kinase (JAK) pathway is involved. Therefore, the potential of JAK inhibitors as therapeutic agents for AA is attracting attention. Several single‐arm clinical trials and retrospective studies demonstrated that oral JAK inhibitors are effective and tolerable treatments for moderate to severe AA. Although JAK inhibitors are emerging as an innovative treatment for AA, further placebo‐controlled clinical trials are required to confirm their efficacy and long‐term safety.
Targeted prey fields determine foraging effort thresholds of a marine diver: Important cues for the sustainable management of fisheries
Authors: McInnes Alistair M. , Ryan Peter G. , Lacerda Miguel , Pichegru Lorien 
Published: June 2019

Abstract

Understanding functional relationships between seabirds and prey can play an important role in the sustainable management of fisheries that compete for the same resources yet data linking the foraging performance of seabirds directly with concurrent information on prey supplies remain limited.

We assess the influence of prey availability on the foraging performance of breeding African penguins Spheniscus demersus using data from instrumented birds during 14 pelagic fish surveys carried out over 3 years around their two largest breeding colonies, St Croix and Bird islands in Algoa Bay. Characteristics of prey fields targeted by African penguins were identified by assessing the response of foraging birds to the acoustically determined distribution of small pelagic fish. Path‐ and dive‐derived foraging performance metrics were modelled as a response to overall and targeted prey abundance estimates to assess potential nonlinear functional relationships between penguin foraging effort and prey availability.

African penguins displayed marked spatial heterogeneity in their selection of foraging sites, but birds from both colonies invariably foraged on fish schools <40 m deep.

Generalized additive model fits improved for all foraging performance responses when using targeted prey abundance (i.e. only fish in areas frequented by penguins and at depths <40 m, as opposed to estimates using all prey). Models for trip duration (r2 = 0.45) and foraging path length (r2 = 0.44) showed a negative nonlinear form in their response to targeted prey abundance, with significant improvement in penguin foraging effort when prey abundance was greater than 45% of the maximum prey biomass recorded.

Synthesis and applications. Functional relationships between seabird foraging performance and prey supplies have the potential to inform the sustainable management of fisheries that compete for the same prey. Our findings highlight the importance of quantifying prey that is available to seabirds when assessing critical thresholds in prey abundance below which seabird foraging performance is adversely affected. These findings can be integrated into dynamic ocean management strategies to mitigate resource competition around seabird colonies. A framework for flexible, colony‐centred closures is proposed as a more dynamic alternative to time/area closures with the potential to respond to prevailing habitat conditions in near real‐time.
The Utility of Skeletal and Surgical Features for the Personal Identification Process: A Pilot Study
Authors: Cappella Annalisa , Gibelli Daniele , Obertová Zuzana , Cummaudo Marco , Castoldi Elisa , De Angelis Danilo , Sforza Chiarella , Cattaneo Cristina 
Published: June 2019

AbstractThis pilot study provides a conceptual framework for the application of the anthropological analysis of skeletal features and surgical interventions for the purpose of identification in cases of unknown deceased individuals with unavailable fingerprint, genetic or odontological antemortem data. The study sample includes 276 individuals with known demographic and clinical information from the Italian CAL Milano Cemetery Skeletal Collection. In the sample, 124 (45%) individuals showed one or more skeletal features that may be potentially individualizing. Of these, 79% showed two and more features, which occurred in a multitude of different combinations. Skeletal findings may provide useful postmortem information that can be compared with antemortem witness statements and clinical imaging. However, more research into the utility of dry bone findings and the availability of comparative material, including imaging, and epidemiological data needs to be undertaken before skeletal features can be implemented into identification protocols and databases.
Complexity of care processes in a radiation oncology service and its implications concerning the distribution of work and associated costs
Authors: Alia Ramos Avelino , Cobos‐Campos Raquel , Poza De Celis Raul 
Published: June 2019

AbstractIntroductionAmong several different instruments developed to compare the complexity of healthcare processes, relative value units (RVUs) are among the most well‐known and widely used in hospitals, but despite being a recognized management tool, in our setting, the few studies published have been based on theoretical assumptions. Our objective was to assess the level of complexity of each process in our service and to determine the RVUs generated, in order to relate complexity and costs.MethodsDuring 2014, data were retrospectively collected for 840 cancer patients from the Radiation Oncology Department, Araba University Hospital. Activity times and costs were subsequently assigned to calculate RVUs for each activity, cancer subtype and treatment option.ResultsThe activity associated with the lowest cost, assigned an RVU of 1, was simulation (phase changes) in treatment, with an annual cost of €9933, while that with the highest cost, assigned the greatest number of RVUs, was administration of treatment by radiotherapy technicians (RTTs) (€633,754 and 63.80 RVUs). The care process that consumed the most resources was adjuvant treatment of breast cancer (€998,070), equivalent to 364.62 RVUs compared to the cheapest subtype of adjuvant treatments or 2440 RVUs compared to the care process that used the fewest resources overall.ConclusionThe most expensive activities are those which are the most complex or consume the most resources. Knowledge of RVUs may be employed to analyse our activity and assess the possibility of increasing the efficiency of our service without prejudicing quality.