bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Prognosis Between Epidermal Growth Factor Mutation Positive and Negative Groups in Lung Adenocarcinoma Patients with Brain Metastases
Authors: UNAT Damla SERÇE , ARIKAN Şener , BALCI Günseli , ERMİN Sinem , MERTOĞLU Aydan , KIRBIYIK Ozgur 
Published: October 2024

Abstract

Introduction:
Brain Metastasis (BM) in Non-Small Cell Lung Cancer (NSCLC) is still important reason of morbidity and mortality despite the advances in the cancer treatment. Using Tyrosine Kinase Inhibitors against Epidermal Growth Factor Receptors (EGFR) mutations revolutionized in NSCLC treatment. We investigated whether the presence of EGFR mutation influences survival in patients with Lung Adenocarcinoma with BM.
Material and Methods
The data of the patients with pathological diagnosis of NSCLC and BM at tertiary hospital were analyzed retrospectively in terms of survival. A total of 2554 patients diagnosed with NSCLC pathologically between 01.01.2010 and 01.01.2021 were identified. After exclusion of patients with lack of data, unknown EGFR mutation status, no brain metastasis and additional malignancy 336 patients were included to the study.
Results
It is found that EGFR (+) patients were more female dominant (48.6% vs 13.3% p < 0.0001) and were have less history of smoking (%47.2 vs %87.1, p < 0.0001) and were better survival (%79.2 vs %92.8). We found negativity of EGFR increased death risk by 1.700 times (95% CI: 1.323–2.183, p < 0.0001) in univariate analysis and by 1.724 times (95% CI 1.251–2.377, p = 0.0001) in multivariate analysis. When overall survivals have been compared estimated overall survival time of EGFR (-) patients were 10.088 (95% CI 8.571–11.606) months and of EGFR (+) patients were 11.829 months (95% CI 10.336–13.323) (p < 0.001).
Conclusion
EGFR positivity was associated with survival. Also, survival was significantly longer in EGFR-positive patients with brain metastases diagnosed with NSCLC.
Differential Excitatory-Inhibitory Balance within Dorsolateral Prefrontal Cortex Shapes Inter-network Interactions in Working Memory
Authors: Yi Chunzhi , Zhu Haiqi , Zhang Shaoshi , Li Yangping , Lv Zehua , Zhou Shijie , Wei Baichun 
Published: October 2024

Abstract

Working memory involves complex activation of and interactions among multiple brain areas. However, little is known about how these large-scale activity and interaction patterns relate to resting state activity and originate from excitatory and inhibitory interactions. Here, we combine the analysis of fMRI activation, functional and structural connectivity with large-scale neural network modelling and molecular-enriched PET analysis to show how the excitatory and inhibitory neuronal activities within dorsolateral prefrontal cortex (DLPFC) relate to the inter-network interactions and activation patterns aroused by working memory tasks. Our results indicate that the activation and interaction of the frontoparietal and default-mode networks, which differ between resting state and working memory, depend on the level of DLPFC activity and on its functional and structural interactions with these networks. By perturbing a large-scale neural network model developed using resting-state fMRI and performing molecular-enriched analysis on both fMRI and PET images, we find evidence that a differential activation of excitatory and inhibitory vs neuron populations within DLPFC may ignite the transition from the resting state to working memory. Our study provides a mechanistic understanding of how regional DLPFC excitatory and inhibitory neural activity combines with functional and structural inter-area connections to support the large-scale network dynamics supporting working memory.
Clinical effect analysis of three-port laparoscopic and choledochoscopic common bile duct exploration without T-tube in the treatment of emergency cholecystolithiasis combined with common bile duct stones
Authors: Wang Xirang , Li Yuxiang , Kang Jian , Wu Yunpeng , Zhang Jun , Tao Hehui , Wang Li , Rong Ruizhou , Wang Miao , Liu Kang , Ban Zhen 
Published: October 2024

Abstract

Objective
To investigate the clinical application value of three-port laparoscopy combined with choledochoscopic common bile duct exploration without T tube in the treatment of emergency patients with choledocholithiasis.
Methods
From December 2023 to July 2024, the clinical data of 103 patients with emergency cholecystolithiasis complicated with common bile duct stones in the Department of General Surgery, Beijing Fengtai Youanmen Hospital were collected. Among them, 44 patients underwent three-port laparoscopy combined with choledochoscopy for common bile duct exploration without T-tube operation, and 59 patients underwent four-port laparoscopy combined with choledochoscopy for common bile duct exploration with T-tube drainage. The preoperative, intraoperative and postoperative indexes of the two groups were compared.
Results
There was no significant difference in preoperative general data between the two groups (all P > 0.05). Three-port laparoscopic T-tube-free method was better than four-port laparoscopic T-tube method in postoperative pain, removal of abdominal drainage tube and length of hospital stay (all P<0.05). There was 1 case of pancreatitis in each group. There was no conversion to open surgery, no residual stones, no hemobilia and no biliary stricture in both groups. There was 1 case of bile leakage after four-hole T-tube placement and 1 case of bile leakage after T-tube removal.
Conclusion Three-hole laparoscopy combined with choledochoscopy for common bile duct exploration without T-tube in emergency patients is safe and feasible. Compared with T-tube group, T-tube-free method is more consistent with the concept of rapid recovery.
Engagement in outreach services among persons experiencing unsheltered homelessness in a Southwestern Urban County: A spatial study
Authors: Mercado Micaela , Drobnyh Klim , Gentry Katie , Law Lara , Shuman Sara , Dibarrart Francisca , Runger George , Ferguson Kristin 
Published: October 2024

Abstract

This study explored how engagement in street outreach services is impacted by the locations where structurally vulnerable individuals experiencing unsheltered homelessness enroll. Logistic regression models were applied to 2022 outreach service contact data to analyze spatial concentrations of engagement across 11 location types. The highest spatial concentration of outreach service contacts occurred in the downtown area of an urban city. Results showed that gender, race, and ethnicity moderated the relationship between engagement and locations where contacts occurred. Among racial and ethnic groups, American Indian/Alaska Native/Indigenous and Hispanic/Latino clients had significantly lower odds of outreach service contacts near the downtown area compared to White clients. In comparison, Black/African American/African and Asian/Asian American clients had higher odds. Additionally, Black/African American/African women had lower odds of outreach service contacts near the downtown area compared to White women. Women had higher odds of contacts near motels than men. High utilizers of outreach services had higher odds of contacts near the downtown area, with gender and race moderating this relationship. Spatial analysis is a novel approach to understanding geographic context where structurally affected individuals engage in services. These findings highlight the need to tailor outreach strategies better to serve diverse populations in different geographic contexts.
A contribution to 3D tracking of deformable bubbles in swarms using temporal information
Authors: Wang Lantian , Ma Tian , Lucas Dirk , Eckert Kerstin , Hessenkemper Hendrik 
Published: October 2024

Abstract

Reliable Lagrangian 3D tracking of individual bubble swarm members allows a deeper understanding of hydrodynamic bubble-bubble interactions and their collective rise. For multi-view measurements, we have recently developed such a tracking method \citep{hessenkemper20243d}, which is able to track deformable bubbles with low to moderate view obstruction through the bubbles to each other. In the present work, we aim to further enhance the 3D tracking performance by incorporating 2D temporal information in the form of previously established 2D tracks in each view. The new 3D tracking method is able to disambiguate cross-view object associations at each time step by using the 2D track information accumulated over time. In addition, the 2D track information is used in two post-processing steps to improve the completeness of established 3D trajectories. Compared to the previous 3D tracking method, the extended 3D tracking framework shows noticeable improvements in tracking ability, accuracy and completeness of trajectories.
Central Nervous System depressant outcome of Artemisia monosperma Delile ethanolic extract in male rats via modulating GABAergic pathway: Phytochemical analysis
Authors: Elewa Naglaa Z. , Khairy Mohamed H. , Ahmed Amal M. , Abdelaty Asmaa I. , Amro Ahmed , Zeid Ehsan Abu 
Published: October 2024

Abstract

This current study aimed to examine the depressive outcome of Artemisia monosperma Delile ethanolic extract (ARM-EE) on the central nervous system (CNS) of male rats. Screening phytochemicals was done using GC˗MS and HPLC analysis. The study included four equal groups (n = 10): 1st Control, 2nd Diazepam (DIZ 1 mg/kg B.wt.), 3rd ARM high group (ARM-H 800 mg/kg B.wt.), and 4th ARM low group (ARM-L 400 mg/kg B.wt). Dosing was orally and daily for 21 days. The acute oral LD50 was valued to be more than 2 g/kg. HPLC analysis revealed the presence of vanillin, syringic acid, naringenin, coffeic acid, rutin, gallic acid, and querectin. Administration of ARM-EE extract significantly (p < 0.001) decreased the hole crosses and fall-off time in the rotarod test. In the open field test, ARM-EE significantly (p < 0.001) decreased locomotor and exploratory behaviors. ARM-EE administration significantly (p < 0.05) increased the brain γ-aminobutyric acid (GABA), dopamine (DA), and serotonin (5˗HT) levels. ARM-EE administration significantly (p < 0.05) up-regulated the brain mRNA expression levels of GABA type a receptor-associated protein (Gabarap) and brain-derived neurotrophic factor (BDNF), meanwhile, expression levels of monoamine oxidase A (Maoa) was significantly (p < 0.05) downregulated. The results of the ongoing research suggest for the first time that the A. monosperma ethanolic extract owns CNS depressant and antioxidative outcomes in a murine model. The CNS-depressive properties of the ARM-EE could be attributable to its phytochemical components. Further toxicological studies are required for the semi-purified phytochemical components of the ARM plant.
Grants and innovations: Funding world innovations, interregional knowledge transfer, or neighbourhood copycats
Authors: Röder Martin , Procher Vivien D. , Urbig Diemo 
Published: October 2024

Abstract

When funding innovations, policy makers often prioritize explorative innovations because of their novelty, overlooking the varied newness within exploitative innovations. By focusing on the imitative nature of exploitative innovations, we distinguish between local imitation — simple replication — and interregional imitation, which involves cross-regional knowledge transfer that is critical for industry renewal and national competitiveness. Examining 4,093 startups, we advocate for a nuanced approach to grantmaking that is tailored to a firm’s industry and strategic position as defined by its entrepreneurial orientation (EO). Our results show that grants foster explorative innovation in high EO startups, while low EO startups contribute through interregional knowledge transfer. This highlights the importance of recognizing high and low EO as different strategic approaches in innovation policy and emphasizing interregional knowledge transfer as an important source of market novelty.
Contemporary strategies for marketing electronic library resources to students: a study of technical universities in Ghana
Authors: Baayel Patrick 
Published: October 2024

Abstract

This paper is derived from a recently concluded doctoral study which delved into innovative strategies for marketing electronic resources (e-resources) in technical universities in Ghana. The ultimate focus was on enhancing student engagement and utilisation of e-resources. The research adopted mixed method design where both quantitative and qualitative processes were employed to gather insights. A sample of 932 (5%) registered student users out of 18,640 from 10 technical universities (TUs) were selected using a stratified random sampling process. Additionally, 34 library professionals were included using a census approach. The respondent rates were 76% (706) for student respondents and 62% (21) for library and information professionals. The study findings indicate that the predominant methods for creating awareness among students include being directed by lecturers, informed by colleagues, library notices, posters, signage, and orientation events. Additionally, Web 2.0 technologies, predominantly social media marketing, instant SMS messages, URL links, institutional website projection, video and audio tutorials, and digital display screens, are all well accepted by students for promoting e-resources. The study emphasises the importance of leveraging technology-based marketing strategies for effective e-resource marketing and recommends integrating these strategies and tools into Ghanaian TU libraries’ marketing efforts. The aim is to maximise the visibility, accessibility, and utilisation of e-resources. This research provides valuable insights for libraries in technical universities to improve their marketing approaches and enhance student engagement with e-resources.
Expanding Elastic Moduli Bounds in Solid-Void Metamaterials: Poisson's Ratio Dependence and Optimal Design
Authors: Tekoğlu Cihan , Ickin Oguz 
Published: October 2024

Abstract

Two-phase solid-void mechanical metamaterials achieve exceptional properties through microstructural adjustments, including any isotropic Poisson’s ratio (−1 to 1 in two dimensions, −1 to 0.5 in three dimensions). Establishing theoretical bounds on these properties is essential for optimising material performance. However, as demonstrated herein, current research often overlooks isotropy constraints, limiting the upper bounds of elastic moduli to a narrow range of Poisson's ratios. In this study, we extend these bounds, revealing significant variability contingent on Poisson's ratio. Through the analysis of five truss lattice materials, each approaching these new bounds in specific Poisson's ratio ranges, we elucidate the interrelationships among deformation mechanisms, elastic moduli, and Poisson's ratio. Notably, we present the first stretching-dominated, isotropic, two-dimensional lattice materials that approach the upper elastic moduli limits as Poisson's ratio approaches -1. These findings provide valuable guidance for designing lightweight, stiff metamaterials across the entire Poisson's ratio spectrum.
Restroom access and health among people experiencing homelessness: A focus on San Diego, CA
Authors: Calzo Jerel P. , Carson Jacob , Swayne Madison R. E. , Felner Jennifer K. , Carroll Megan Welsh 
Published: October 2024

ABSTRACT

Access to restrooms is vital to personal and public health, particularly among people experiencing homelessness (PEH). This study investigated how restroom access is associated with three domains of self-reported physical health (voiding and defecation-related conditions; skin conditions; and hypertension) among PEH in San Diego, CA. Data from 115 structured interviews with PEH (67.8% male, 40.0% mono-racially White, 57.4% rough sleeping) indicated that 37.4% (n = 43) reported typically using public restroom facilities, 38.3% (n = 44) reported typically using private facilities, and 23.5% (n = 27) reported typically engaging in open defecation. There were moderate to strong associations between urinary, gastrointestinal, and dermatological health conditions and stressors/barriers related to restroom access. The proportion of participants with ≥1 skin-related health conditions who engaged in open defecation was substantially higher (40%) compared to participants who reported no skin-related health conditions who engaged in open defecation (17.9%) (χ2(df = 1,108) = 5.25, p = 0.02). Participants who reported ≥3 voiding or defecation-related health conditions or ≥1 skin-related health conditions reported higher mean restroom-related impediments to health relative to participants without these health conditions. Restricted restroom access may prevent PEH from fulfilling their basic sanitation and hygiene needs, and may exacerbate urinary, gastrointestinal, and skin health conditions.
Mechanism Exploration of Astaxanthin in the Treatment of Adriamycin-induced Cardiotoxicity Based on Network Pharmacology and Experimental Validation
Authors: Zhu Yu , Chen Mengyao , Xie Lin , Pan Yijun , Yang Yuntian , Wan Guoxing 
Published: October 2024

Introduction:
Astaxanthin (AXT), a natural antioxidant recognized for its
therapeutic potential in cancer and cardiovascular diseases, holds promise in mitigating
adriamycin-induced cardiotoxicity (AIC). Nevertheless, the underlying mechanisms of
AXT in AIC mitigation remain to be elucidated. Consequently, this study endeavors to
elucidate the mechanism of AXT against AIC, employing an integrated approach.

Methods:
Network pharmacology, molecular docking, and molecular dynamics simulations
were harnessed to explore the molecular mechanism underlying AXT's action
against AIC. Furthermore, the in-vitro AIC model was established with the H9c2 cell to
generate transcriptome data for validation.

Results:
A total of 533 putative AXT targets and 1478 AIC-related genes were initially
screened by database retrieval and bioinformatics analysis. A total of 248 potential targets
of AXT against AIC and several signaling pathways were identified by network
pharmacology and enrichment analysis. Two core genes (CCL2 and NOS3) and the
AGE-RAGE signaling pathway in diabetic complications were further highlighted by
transcriptome validation based on the AIC in-vitro model. Additionally, molecular docking
and dynamics analyses supported the robust binding affinity of AXT with the core
targets.

Conclusion:
The study suggested that AXT might ameliorate AIC through the inhibition
of CCL2 and NOS3 as well as AGE-RAGE signaling, which provide a theoretical basis
for the development of a strategy against AIC.
Cardiovascular Mortality Risk among Patients with Liver Cancer: A SEER Database Study
Authors: Li Juan , Zhang Junyong , He Song 
Published: October 2024

Abstract:
Crucial for understanding their overall health outcomes. This research aimed to as-sess the CVM risk of liver cancer patients.

Methods and Materials:
Data sourced from the Surveillance, Epidemiology, and End Results (SEER) database encompassing liver cancer diagnoses from 2000 to 2017 were utilized. The standardized mortality rate (SMR) was computed using general population reference data, and multivariate competing risk models were employed for analysis.

Results:
Analysis of 70,733 liver cancer patient records revealed 1,954 instances of CVM. The overall CVM SMR for liver cancer patients was 12.01 (95% CI: 11.48-12.55). Various demographic and clinical factors, including sex, race, age, year of diagnosis, pathological type, general stage, treatment modalities, and matrimonial status, emerged as liver cancer pa-tients` independent predictors of CVM.

Conclusion:
Liver cancer patients have a notably heightened susceptibility to cardiovascular mortality (CVM) in contrast to the general populace. It is imperative to promptly recognize high-risk subcategories and execute tailored cardiovascular interventions as crucial measures to bolster survival rates within this cohort of patients.

conclusion:
Liver cancer patients have a notably heightened susceptibility to cardiovascular mortality (CVM) in contrast to the general populace. It is imperative to promptly recognize high-risk subcategories and execute tailored cardiovascular interventions as crucial measures to bolster survival rates within this cohort of patients.
Topical Application of Melatonin in a Grapeseed Oil-based Microemulsion Accelerated Wound Healing in Rat Models
Authors: Gupta Madhavi , Marbaniang Daphisha , Pal Paulami , Gogoi Niva Rani , Chakrabarti Srijita , Chattopadhyay Pronobesh , Ray Subhabrata , Mazumder Bhaskar 
Published: October 2024

Objective:
Melatonin has been associated with accelerated tissue regeneration and
grapeseed oil has abundant unsaturated fatty acids, particularly linoleic acid that makes it a
strong antioxidant, having the potential to promote wound healing by enhancing the presence of
free radicals at the wound site. The study is aimed to evaluate the potential of a microemulsion
gel using grapeseed oil as the organic phase and melatonin encapsulated in the vesicles to exhibit
synergistic wound healing in Swiss albino rats.

Materials and Method:
Microemulsion containing grapeseed oil encapsulating melatonin was
developed using the water-titration method. The surfactant and co-surfactant ratio (Smix) were
fixed at 1:1. A pseudo-ternary diagram was used to determine the microemulsion zone and the
developed microemulsion was further incorporated in carbopol 934P gel. The formulations were
evaluated for their physicochemical properties and cytotoxicity assay. The optimized formulation
was topically applied to cutaneous wounds of Swiss albino rat models. 30 Swiss albino rats
were divided into five groups of 6 animals each: (i) Negative control group, (ii) Standard marketed
formulation treated group, (iii) Optimized microemulsion containing Grapeseed oil and
melatonin treated group, (iv) Grapeseed oil treated group and (v) Melatonin treated group. All
the rats in each group were topically applied with the desired formulations daily for up to 14
days.

Results:
The treatment with a formulation comprising 10.18% Grapeseed oil, 24.88% water, and
64.94% Smix exhibited the highest entrapment efficiency of 86.65 ± 1.88% with an enhanced in
vitro drug release of up to 83.02 ± 1.09%, also demonstrating first-order release kinetics. Furthermore,
it did not inhibit L929 mouse fibroblast cell proliferation up to 500 μg/mL and promoted
wound closure prior to other groups. Additionally, increased tissue maturation with higher
collagen deposition was mostly seen by day 7. Thus demonstrating it is suitable for dermal
application and sustained release of melatonin. The in vivo wound healing study and histological
investigations on rat models demonstrated comparable results as observed in the marketed formulation
of melatonin.

Conclusion:
The results showed that GSO oil based microemulsion encapsulating MEL could
be a promising wound treatment option to exhibit accelerated wound healing effects.