bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood microvasculature and lymphatic densities in endometrial polyps and adjacent and distant endometrium
Authors: Nijkang Njume Peter , Anderson Lyndal , Markham Robert , Fraser Ian Stewart , Manconi Frank 
Published: March 2018

Objective: Endometrial polyps are localised growths of endometrial tissue containing glands, stroma and blood vessels, covered with epithelium. The reported prevalence of endometrial polyps is dependent upon the population being studied and the uterine imaging technique utilised. The light microscopy literature provides very little information regarding their microvasculature and lymphatic systems; however, a plethora of ultrasound data demonstrating single central arteries in most medium- or large-sized endometrial polyps are well documented. Methods: Archived formalin-fixed paraffin-embedded blocks of endometrial curettings were retrieved from files for women with confirmed endometrial polyps ( n = 20) and women with normal endometrium (control endometrium; n = 32). Immunohistochemistry was performed with the antibodies CD31 (blood vessels) and D2-40 (lymphatics). Blood vessels and lymphatics were quantified in endometrial polyps and adjacent, distant and control endometrium. Results: CD31 and D2-40 staining was present in all specimens, although there were no significant differences in blood vessel ( F(3,70) = 2.36, p = 0.079) and lymphatic ( F(3,70) = 0.16, p = 0.920) densities between endometrial polyps as well as adjacent, distant and control endometrium. There were also no significant differences in women with endometrial polyp-associated bleeding and those with no bleeding. In relation to infertility, there were no significant differences found in blood and lymphatic densities between women with endometrial polyps who were infertile and those with endometrial polyps who were fertile. Conclusion: Small blood vessel wall and perivascular structures rather than the distribution of vessels may be associated with abnormal bleeding.
MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD
Authors: Major-Monfried Hannah , Renteria Anne S. , Pawarode Attaphol , Reddy Pavan , Ayuk Francis , Holler Ernst , Efebera Yvonne A. , Hogan William J. , Wölfl Matthias , Qayed Muna , Hexner Elizabeth O. , Wudhikarn Kitsada , Ordemann Rainer , Young Rachel , Shah Jay , Hartwell Matthew J. , Chaudhry Mohammed S. , Aziz Mina , Etra Aaron , Yanik Gregory A. , Kröger Nicolaus , Weber Daniela , Chen Yi-Bin , Nakamura Ryotaro , Rösler Wolf , Kitko Carrie L. , Harris Andrew C. , Pulsipher Michael , Reshef Ran , Kowalyk Steven , Morales George , Torres Ivan , Özbek Umut , Ferrara James L. M. , Levine John E. 
Published: March 2018

Key Points
Biomarker scores generated after 1 week of steroid treatment of GVHD are prognostic. Biomarkers reflect prognosis better than early clinical response to GVHD treatment.
Multimorbidity medications and poor asthma prognosis
Authors: Chanoine Sébastien , Sanchez Margaux , Pin Isabelle , Temam Sofia , Le Moual Nicole , Fournier Agnès , Pison Christophe , Bousquet Jean , Bedouch Pierrick , Boutron-Ruault Marie-Christine , Varraso Raphaëlle , Siroux Valérie 
Published: March 2018

Multimedication related to multimorbidity is common in the elderly with asthma. We aimed at comprehensively characterising medications used by elderly women and assessing how multimedication impacts on asthma prognosis.We performed network-based analyses on drug administrative databases to visualise the prevalence of drug classes and their interconnections among 17 458 elderly women from the Asthma-E3N study, including 4328 women with asthma. Asthma groups sharing similar medication profiles were identified by a clustering method relying on all medications and were studied in association with adverse asthma events (uncontrolled asthma, attacks/exacerbations and poor asthma-related quality of life).The network-based analysis showed more multimedication in women with asthma than in those without asthma. The clustering method identified three multimedication profiles in asthma: “Few multimorbidity-related medications” (43.5%), “Predominantly allergic multimorbidity-related medications” (32.8%) and “Predominantly metabolic multimorbidity-related medications” (23.7%). Compared with women belonging to the “Few multimorbidity-related medications” profile, women belonging to the two other profiles had an increased risk of uncontrolled asthma and asthma attacks/exacerbations, and had lower asthma-related quality of life.The integrative data-driven approach on drug administrative databases identified specific multimorbidity-related medication profiles that were associated with poor asthma prognosis. These findings support the importance of multimorbidity in the unmet needs in asthma management.
Implication of Major Adverse Postoperative Events and Myocardial Injury on Disability and Survival: A Planned Subanalysis of the ENIGMA-II Trial
Authors: Beattie W. Scott , Wijeysundera Duminda N. , Chan Matthew T. V. , Peyton Philip J. , Leslie Kate , Paech Michael J. , Sessler Daniel I. , Wallace Sophie , Myles Paul S. 
Published: March 2018

BACKGROUND:
Globally, >300 million patients have surgery annually, and ≤20% experience adverse postoperative events. We studied the impact of both cardiac and noncardiac adverse events on 1-year disability-free survival after noncardiac surgery.

METHODS:
We used the study cohort from the Evaluation of Nitrous oxide in Gas Mixture of Anesthesia (ENIGMA-II) trial, an international randomized trial of 6992 noncardiac surgical patients. All were ≥45 years of age and had moderate to high cardiac risk. The primary outcome was mortality within 1 postoperative year. We defined 4 separate types of postoperative adverse events. Major adverse cardiac events (MACEs) included myocardial infarction (MI), cardiac arrest, and myocardial revascularization with or without troponin elevation. MI was defined using the third Universal Definition and was blindly adjudicated. A second cohort consisted of patients with isolated troponin increases who did not meet the definition for MI. We also considered a cohort of patients who experienced major adverse postoperative events (MAPEs), including unplanned admission to intensive care, prolonged mechanical ventilation, wound infection, pulmonary embolism, and stroke. From this cohort, we identified a group without troponin elevation and another with troponin elevation that was not judged to be an MI. Multivariable Cox proportional hazard models for death at 1 year and assessments of proportionality of hazard functions were performed and expressed as an adjusted hazard ratio (aHR) and 95% confidence intervals (CIs).

RESULTS:
MACEs were observed in 469 patients, and another 754 patients had isolated troponin increases. MAPEs were observed in 631 patients. Compared with control patients, patients with a MACE were at increased risk of mortality (aHR, 3.36 [95% CI, 2.55–4.46]), similar to patients who suffered a MAPE without troponin elevation (n = 501) (aHR, 2.98 [95% CI, 2.26–3.92]). Patients who suffered a MAPE with troponin elevation but without MI had the highest risk of death (n = 116) (aHR, 4.29 [95% CI, 2.89–6.36]). These 4 types of adverse events similarly affected 1-year disability-free survival.

CONCLUSIONS:
MACEs and MAPEs occur at similar frequencies and affect survival to a similar degree. All 3 types of postoperative troponin elevation in this analysis were associated, to varying degrees, with increased risk of death and disability.
Polycomb group (PcG) proteins and Pax6 cooperate to inhibit in vivo reprogramming of the developing Drosophila eye
Authors: Zhu Jinjin , Ordway Alison J. , Weber Lena , Buddika Kasun , Kumar Justin P. 
Published: March 2018

ABSTRACT
How different cells and tissues commit to and determine their fates has been a central question in developmental biology since the seminal embryological experiments conducted by Wilhelm Roux and Hans Driesch in sea urchins and frogs. Here, we demonstrate that Polycomb group (PcG) proteins maintain Drosophila eye specification by suppressing the activation of alternative fate choices. The loss of PcG in the developing eye results in a cellular reprogramming event in which the eye is redirected to a wing fate. This fate transformation occurs with either the individual loss of Polycomb proteins or the simultaneous reduction of the Pleiohomeotic repressive complex and Pax6. Interestingly, the requirement for retinal selector genes is limited to Pax6, as the removal of more downstream members does not lead to the eye-wing transformation. We also show that distinct PcG complexes are required during different developmental windows throughout eye formation. These findings build on earlier observations that the eye can be reprogrammed to initiate head epidermis, antennal and leg development.
Hormonally mediated effects of artificial light at night on behavior and fitness: linking endocrine mechanisms with function
Authors: Ouyang Jenny Q. , Davies Scott , Dominoni Davide 
Published: March 2018

ABSTRACTAlternation between day and night is a predictable environmental fluctuation that organisms use to time their activities. Since the invention of artificial lighting, this predictability has been disrupted and continues to change in a unidirectional fashion with increasing urbanization. As hormones mediate individual responses to changing environments, endocrine systems might be one of the first systems affected, as well as being the first line of defense to ameliorate any negative health impacts. In this Review, we first highlight how light can influence endocrine function in vertebrates. We then focus on four endocrine axes that might be affected by artificial light at night (ALAN): pineal, reproductive, adrenal and thyroid. Throughout, we highlight key findings, rather than performing an exhaustive review, in order to emphasize knowledge gaps that are hindering progress on proposing impactful and concrete plans to ameliorate the negative effects of ALAN. We discuss these findings with respect to impacts on human and animal health, with a focus on the consequences of anthropogenic modification of the night-time environment for non-human organisms. Lastly, we stress the need for the integration of field and lab experiments as well as the need for long-term integrative eco-physiological studies in the rapidly expanding field of light pollution.
A case report of horner's syndrome presenting post bimaxillary osteotomy
Authors: Kidner Melanie , Hussain Omar , Shelton Andrew , Scott Paul 
Published: March 2018

Bimaxillary osteotomy is a surgical procedure used to correct dentofacial deformity. Although the complication rates are low, there are some rare but serious complications of this procedure. 1 This article looks at the recognized complications of orthognathic surgery and describes a previously undocumented incident of a patient who developed Horner's syndrome post bimaxillary osteotomy. CPD/Clinical Relevance: Although the general incidence of Horner's syndrome is low it can occur as an uncommon but serious complication of a variety of invasive surgical procedures. Its development can also be the sign of serious underlying disease, therefore it is important for all clinicians to be aware of the clinical signs of the syndrome and the appropriate management.
Day-case holmium laser enucleation of the prostate: feasibility, safety and predictive factors
Authors: Lee S-M , Gordon K , McMillan R , Crystal F , Acher P 
Published: March 2018

Introduction Transurethral resection of the prostate has remained the most common operation for bladder outlet obstruction in the UK, but it is associated with potential morbidity and median two-day length of hospital stay. Holmium laser enucleation of the prostate (HoLEP) provides an alternative procedure. Provision of day-case HoLEP would improve patient care through increased efficiency. We assessed the feasibility and safety of day-case HoLEP and examined predictive factors for increased length of hospital stay. Materials and methods Patients presenting for HoLEP by a single surgeon from September 2013 to September 2016 were considered for day-case surgery. Patients were discharged following assessment by the operating surgeon and met predetermined discharge criteria. Factors contributing to day-case success were identified. Results In total, 210 patients (mean age 70.3 ± 8.5 years) underwent HoLEP, with 74 (35.3%) discharged as true day-cases and a further 84 (40.0%) discharged within 23 hours. Readmission rate was 5.5%, with all complications Clavien–Dindo grade I or II. Factors associated with successful day-case operation included low-volume prostates (≤ 40 g) (odds ratio, OR, 3.097, 95% confidence interval, CI, 1.619–5.924, P = 0.0001) and morning surgical lists (OR 6.124, 95% CI 2.526-14.845, p<0.001). Discussion and conclusion Day-case HoLEP is both feasible and safe, with low readmission rates. Two factors were significantly associated with successful day-case surgery: small volume prostate and morning theatre lists. Addressing these factors through preoperative planning can improve day-case surgery rates and improve bed throughput.
A motivação para a leitura na escola: contribuições do ensino de literatura
Authors: Galvão André Luis Machado , Silva António Carvalho da 
Published: March 2018

Este trabalho discute a importância da leitura para o mundo contemporâneo e como ela tem sido trabalhada na escola, considerando em que termos o ensino de literatura pode ser motivador da formação do gosto pelo ato de ler. A partir de pesquisa bibliográfica, são analisadas concepções e teorias que embasam as considerações que norteiam a pesquisa. É possível concluir que o ensino de literatura, através do letramento literário, pode se constituir como recurso motivador para que, no ambiente escolar, venha a ocorrer a formação de leitores críticos e autônomos.
LRS Bianchi type-I Universe with anisotropic dark energy and special form of deceleration parameter in f (R, T) gravity
Authors: Wankhade Rajesh , Bansod A.S. 
Published: March 2018

In this paper, LRS Bianchi type-I space-time is considered in the presence of perfect fluid source in the frame work of Â gravity (Harko et al. in Phys.Rev. D 84:024020, 2011) where is an arbitrary function of Ricci scalar Â and trace of the energy momentum tensor . The Einsteinâ€™s field equations have been solved by taking into account the special form of deceleration parameter (Singha A., Debnath U.: Int.J. Theor. Phys.48, 2009). We observe that in f (R, T) gravity, an extra acceleration is always present due to coupling between matter and geometry. The geometrical and physical aspect of the model is also studied.
Figures et dynamiques de la professionnalisation des communicateurs
Authors: Baillargeon Dany , Brulois Vincent , Coyette Catherine , David Marc D. , Lambotte François , Lépine Valérie 
Published: March 2018

Cette recherche menée dans l’espace francophone commun à la Belgique, à la France et au Canada analyse les dynamiques de professionnalisation et identifie les discours et actions performatives qui participent à construire une « figure » du communicateur professionnel. L’analyse inductive d’entrevues auprès de dix-sept représentants actuels et passés de neuf associations professionnelles circonscrit trois formes que prend la figure du professionnel en communication : les valeurs (éthos), les actions (praxis) et les objets (artéfacts). La mise en relation des éléments qui composent ces formes permet d’identifier trois tensions : 1) l’aspiration à une professionnalisation déontique et stratégique pas toujours réalisée; 2) l’idéal véhiculé par les associations et une constante polarisation vers la tâche des professionnels; 3) un apparent débalancement entre les artéfacts normatifs et leur réelle performativité dans la praxis et dans l’éthos. Enfin, même si elle n’offre pas d’explication à ces tensions, cette recherche propose un outil méthodologique qui pourrait servir d’outil d’aide à la mise en place d’une politique professionnelle associative.
Innovation organisationnelle dans la phase amont d’un projet de diplôme universitaire professionnel dans le secteur de la communication digitale
Authors: Larroche Valérie 
Published: March 2018

Cet article présente un retour d’expérience distancié sur la licence marketing digital, gestion de contenus et stratégies numériques de l’IUT Lyon 3 habilitée depuis 2009. L’originalité de cette licence réside dans le choix d’un secteur émergent en 2007 mais aussi dans le fait de constituer un collectif, composé de professionnels et d’universitaires, en amont de la concrétisation du projet. La théorie de la traduction (Callon, 1986) permet de présenter le contexte de l’élaboration de cette licence à l’aide des concepts de problématisation, d’intéressement et d’enrôlement et de discuter du degré d’investissement des instances en présence. Elle permet aussi d’analyser le processus de construction d’une équipe dédiée à la création d’un diplôme dans le secteur du digital. Nous montrons comment au sein de cette équipe, la cooptation et un leadership partagé ont favorisé l’intelligence collective pour établir une maquette pédagogique adaptée aux attentes des professionnels.
This paper presents a critical feedback on the creation of a professionnal bachelor’s degree (“Licence” in the French educational system) in digital marketing, web content management and digital strategy in 2009 at Lyon 3 University. The original features of this licence lie in the choice of an emerging sector (in 2007) and in the creation of a working group composed of professionals and academics for the shaping and designing of this diploma, this at a very early stage. Callon and Latour’s Actor Network Theory (or sociology of translation) is useful to the analysis of the making of this degree. Using their conceptual framework (enrollment, problematization, involvement, etc.) we can put into light the whole process and discuss the degree of investment of the different stakeholders of the project. We will particularly point out how cooptation and shared leadership enhanced a collective intelligence in order to develop an educational model adapted to the needs of professionals.
De la fragmentation procédurale à l’émiettement épistémologique
Authors: Labasse Bertrand 
Published: March 2018

Le développement social, économique et technologique du domaine de la communication s’accompagne d’une spécialisation croissante des pratiques professionnelles et des formations qui leurs sont liées, au risque d’un délitement de la substance académique de ces dernières. Un tel délitement est-il pour autant inéluctable ? Se consacrant au dénominateur commun de ces filières – la production discursive médiatisée sous toutes ses formes – cet article examinera l’hypothèse selon laquelle les problèmes de cohérence perceptibles à l’échelle globale, celle de l’interdiscipline, sont structurellement assimilables à ceux que peut connaître, à l’échelle locale, tout programme de formation universitaire en communication, lesquels sont à leur tour similaires à ceux que l’on peut remarquer à l’échelle d’un simple cours ou même d’un manuel de communication à vocation pratique. On examinera dans un premier temps – en prolongeant une recherche antérieure – comment les connaissances et préceptes opératoires sont structurés dans les manuels, avant de transposer cette analyse à la structuration interne des programmes de formation, ce qui conduira enfin à montrer que la cohérence et les perspectives de la nébuleuse interdisciplinaire que forme l’enseignement de la communication dépend moins des bourgeonnements de sa périphérie que des articulations fondamentales qui en établissent le centre.
Social, economic and technological developments in the field of communication are accompanied by increasing specialization of professional activities and academic programs, to the risk of a disintegration of the academic substance of the field. Is such a disintegration inevitable? Focusing on the common denominator of these curricula – discursive production in all its forms – this article will examine the hypothesis that the problems of consistency visible globally, those of the interdiscipline, are structurally similar to those that encounter, locally, most university programs in communication, which are in turn similar to those that can be observed on the scale of a single course or even of a practical communication guide. We will first examine how the knowledge and precepts are structured in textbooks, before transposing this analysis to the internal structure of training programs, which will lead us to show that consistency and prospects for communication in higher education depends less on its burgeoning periphery that on the fundamental articulations at the center of the interdiscipline.
Le métier de référenceur est-il pérenne et légitime en communication ?
Authors: Domenget Jean-Claude , Michel Jean-Luc 
Published: March 2018

Si la pérennité de ce métier de référenceur n’est plus remise en cause, la question centrale qui reste posée est celle de sa légitimité. Un des objectifs de cet article est de montrer que le métier de référenceur s’inscrit dans la structuration générale des professions de la communication. En premier lieu, il s’agira de valider sa pérennité au travers des diversifications et des recompositions des tâches autour d’un noyau invariant de compétences. En second lieu, l’étude analysera le long cheminement vers la légitimité du référencement en montrant l’élargissement de ses tâches opérationnelles du début à des missions de plus en plus stratégiques et globales. Pour cela, une modélisation dynamique est proposée autour de cinq profils type de référenceurs : les Défricheurs, les Explorateurs, les Organisateurs, les Planificateurs et les Stratèges. Cette modélisation vise à offrir une représentation la plus fidèle possible d’une réalité complexe et mouvante tout en s’inscrivant dans le cadre général de la problématique de l’employabilité. Le référencement vise à franchir une nouvelle étape, celle de gagner sa légitimité, c’est-à-dire d’être jugé assez crédible pour participer aux choix stratégiques en amont de la communication par le web.
If the sustainability of the SEO is no longer questioned, the central question that remains is that of legitimacy. One objective of this article is to show that the job of SEO is in the general arrangement of the communication professions. First, it validates its sustainability through diversification and reconstructions tasks around an invariant core competencies. Secondly, the study analyzes the long journey to the legitimacy of SEO showing the expansion from its operational early tasks to an increasingly strategic and global role. For this purpose, a dynamic model is proposed based on five types of profiles SEOs : the Pioneers, Explorers, Organizers, Planners and Strategists. This model aims to provide the most accurate possible representation of a complex and changing reality while in the wider context of the issue of employability. SEO aims to go one step further, the gain legitimacy, that is to say to be considered credible enough to participate in the strategic choices upstream communication via the web.