bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toxoplasma gondii exposure and epilepsy: A matched case-control study in a public hospital in northern Mexico
Authors: Alvarado-Esquivel Cosme , Rico-Almochantaf Yazmin del Rosario , Hernández-Tinoco Jesús , Quiñones-Canales Gerardo , Sánchez-Anguiano Luis Francisco , Torres-González Jorge , Ramírez-Valles Eda Guadalupe , Minjarez-Veloz Andrea 
Published: April 2018

Objectives: This study aimed to determine the association between infection with Toxoplasma gondii and epilepsy in patients attended to in a public hospital in the northern Mexican city of Durango. Methods: We performed an age- and gender-matched case-control study of 99 patients suffering from epilepsy and 99 without epilepsy. Sera of participants were analyzed for anti- T. gondii IgG and IgM antibodies using commercially available enzyme-linked immunoassays. Seropositive samples to T. gondii were further analyzed for detection of T. gondii DNA by polymerase chain reaction. Results: Anti- T. gondii IgG antibodies were found in 10 (10.1%) of the 99 cases and in 6 (6.1%) of the 99 controls (odds ratio = 1.74; 95% confidence interval: 0.60–4.99; p = 0.43). High (> 150 IU/mL) levels of anti- T. gondii IgG antibodies were found in 6 of the 99 cases and in 4 of the 99 controls (odds ratio = 1.53; 95% confidence interval: 0.41–5.60; p = 0.74). Anti- T. gondii IgM antibodies were found in 2 of the 10 IgG seropositive cases, and in 2 of the 6 IgG seropositive controls (odds ratio = 0.50; 95% confidence interval: 0.05–4.97; p = 0.60). T. gondii DNA was not found in any of the 10 anti- T. gondii IgG positive patients. Bivariate analysis of IgG seropositivity to T. gondii and International Statistical Classification of Diseases and related Health Problems, 10th Edition codes of epilepsy showed an association between seropositivity and G40.1 code (odds ratio = 22.0; 95% confidence interval: 2.59–186.5; p = 0.008). Logistic regression analysis showed an association between T. gondii infection and consumption of goat meat (odds ratio = 6.5; 95% confidence interval: 1.22–34.64; p = 0.02), unwashed raw vegetables (odds ratio = 26.3; 95% confidence interval: 2.61–265.23; p = 0.006), and tobacco use (odds ratio = 6.2; 95% confidence interval: 1.06–36.66; p = 0.04). Conclusions: Results suggest that T. gondii infection does not increase the risk of epilepsy in our setting; however, infection might be linked to specific types of epilepsy. Factors associated with T. gondii infection found in this study may aid in the design of preventive measures against toxoplasmosis.
Absence of high‐risk stigmata predicts good prognosis even in severely anemic patients with suspected acute upper gastrointestinal bleeding
Authors: Horibe Masayasu , Ogura Yuki , Matsuzaki Juntaro , Kaneko Tetsuji , Yokota Takuya , Okawa Osamu , Nakatani Yukihiro , Iwasaki Eisuke , Nishizawa Toshihiro , Hosoe Naoki , Masaoka Tatsuhiro , Yahagi Naohisa , Namiki Shin , Kanai Takanori 
Published: April 2018

BackgroundThe need for a blood transfusion, defined as hemoglobin < 70 g/L, is the measure for assessing the risk levels in patients with upper gastrointestinal bleeding (UGIB). However, not all patients with a low hemoglobin level have a poor prognosis.ObjectiveWe assessed the clinical predictive factors associated with poor short‐term prognosis in patients with a low hemoglobin level.MethodsIn this prospective cohort study, all consecutive patients with suspected acute UGIB at Tokyo Metropolitan Tama Medical Center were enrolled between 2008 and 2015. Then, we extracted those who needed a blood transfusion (hemoglobin < 70 g/L) and explored the variables associated with all‐cause mortality within 28 days after presentation.ResultsAmong 1307 patients, 311 needed a blood transfusion and 13 (4.2%) died from all causes. The presence of high‐risk stigmata requiring endoscopic treatment (peptic ulcers; Forrest scores Ia, Ib and IIa; varices with current bleeding or signs of recent bleeding; and spurting or gushing bleeding or visible vessel in other diseases), diagnosed by emergency endoscopy, was a unique factor affecting mortality (odds ratio: 8.47, 95% confidence interval: 1.45–160, P = 0.01). Patients without high‐risk stigmata neither died from UGIB nor had rebleeding, irrespective of the hemoglobin levels.ConclusionsPatients without high‐risk stigmata showed a good prognosis even if they needed a blood transfusion. This result could facilitate triage of patients with suspected acute UGIB who only need a blood transfusion.
Assessment of clinical effectiveness of haemoglobin spray as adjunctive therapy in the treatment of sloughy wounds
Authors: Hunt Sharon D , Elg Fredrik , Percival Steven L 
Published: April 2018

Objective: To assess use of an adjunctive topical haemoglobin spray in the treatment of sloughy wounds. Method: In addition to a standard wound care regimen, consecutive patients with sloughy wounds self-administered haemoglobin spray treatment twice a week until the wound was healed. All patients were followed-up for 26 weeks. Results were compared with a retrospective cohort of 100 consecutive patients, treated during the same period the previous year with standard wound care alone. Data were collected on wound characteristics including percentage of slough, exudate levels, wound pain, and wound size. Results: After 26 weeks, 94/100 patients (94%) treated with haemoglobin spray were completely healed compared with 63/100 control patients (63%). Positive results were evident as early as week one with 52% mean wound size reduction using the heamoglobin spray versus 11% in the retrospective control (p<0.001). At baseline, mean slough coverage was higher in the haemoglobin group, 58% versus 44% in the control group (p<0.001). By week four, mean slough coverage was 1% in the haemoglobin versus 29% in the control group (p<0.001). Reductions in exudate and pain levels (p<0.001) were also observed. Conclusion: Overall, results of this evaluation showed the addition of adjunctive haemoglobin spray to standard wound care treatment achieved positive clinical outcomes for patients self-managing complicated sloughy wounds, by supporting reduction of wound exudate and slough within the complex multifaceted process of wound healing.
Glycaemic indices and haemoglobin A1c as predictors for non-healing ulcers
Authors: Moore Kevin J. , Dunn Erin C. , Marcus Erin N. , Koru-Sengul Tulay 
Published: April 2018

Objective: Non-healing lower extremity ulcers (NHLU) are a common podiatric complication of diabetes, with poor glycaemic control as a risk factor for development. Glycaemic indices, such as haemoglobin A1c (HbA1c) and fasting plasma glucose (FPG), are used to diagnose and to monitor diabetes. Using a population-based, nationally representative sample, we evaluate the relationship between glycaemic indices and NHLU (as defined by the patient) to propose glycaemic thresholds for clinical suspicion of patient NHLU status. Method: Using data from the 1999–2004 National Health and Nutrition Examination Surveys (NHANES), a total of 9769 adults (≥40 years old) with available self-reported diabetes and NHLU status were analysed. Glycaemic index markers, including FPG and HbA1c, were assessed via laboratory analysis from serum blood samples. Logistic regression models were fitted to determine optimal thresholds for FPG and HbA1c to predict NHLU status. Results: Compared with those without NHLU, NHLU patients were older, male, had higher rates of diabetes, were more likely to take insulin, and had lower total cholesterol. Youden's Index for NHLU identified the optimal FPG threshold as 117.7mg/dl (sensitivity: 33.5%; specificity: 82.6%). The optimal HbA1c threshold was 5.9% (sensitivity: 43.2%; specificity: 77.3%). HbA1c (Odds ratio (OR) 2.44, 95% Confidence Interval (CI) 1.96–3.05; Area under curve (AUC) 0.62) was a stronger discriminator of NHLU compared to FPG (OR 2.19; 95%CI 1.57–3.05; AUC 0.60). Conclusion: This study identified glycaemic thresholds for suspicion of NHLU development that are lower than the glucose goal levels recommended as optimal by the American Diabetes Association. Health professionals should be aware of these glycaemic indices when screening patients with diabetes for NHLU. Future longitudinal and validation studies are necessary to better discern the ideal glycaemic index thresholds to identify NHLU.
Approaching the Jazz Past: MOPDTK’s Blue and Jason Moran’s “In My Mind: Monk at Town Hall, 1959”
Authors: McMullen Tracy 
Published: April 2018

This article analyzes two approaches to the jazz past undertaken recently under the aegis of “jazz reenactment”: Mostly Other People Do the Killing’s 2014 release of Blue (a note-for-note re-performance of the Miles Davis Sextet’s 1959 album, Kind of Blue) and Jason Moran’s multi-media re-visiting of Thelonious Monk’s 1959 Town Hall Concert, “In My Mind: Monk at Town Hall, 1959.” I contend that rather than an ironic critique of the canonization of jazz, Blue is a direct product of the same tradition of understanding the past that informs such canonization. This tradition is based in an epistemology that privileges objectivity, logic, boundaries, and an obsession with naming while suspecting the subjective and what cannot be named. Jason Moran’s “In My Mind,” however, offers a different understanding of the past, one rooted in ambiguity and connection rather than delineation and separation. I argue that this latter understanding offers a necessary critique of conceptions of the past and of self and other found in the dominant Western worldview.
Surplus interword phonological similarity in English multiword units
Authors: Lindstromberg Seth 
Published: April 2018

AbstractPrevious studies found that English figurative idioms alliterate at above chance levels. To permit estimation of amounts of surplus alliteration Gries (2011) calculated baseline levels using an analytic method. This article reports a follow-on investigation covering types of multiword unit (MWU) and types of interword, intraMWU phonological similarity (PhS) considered neither by Gries nor by an even earlier study. In contrast to Gries (2011), baseline levels of PhS were estimated using a stochastic method. In samples of figurative idioms upward departures from baseline levels – expressed as standardized effect sizes – ranged from small to medium for assonance, up to large for alliteration, and even larger for rhyme and alliteration-with-assonance. For samples of (relatively) non-idiomatic MWUs upward departures from baselines were generally small or, in the case of academic collocations, downward. The practicality of the stochastic method is discussed, as are a possible role of interword PhS in the conventionalization of word strings and possible roles of interword, intra-idiom PhS in oral communication. Overall, the findings are problematic for a non-usage-based theory but compatible with a cognitive linguistic theory in which motivation can operate entirely within the phonological pole of a MWU.
Preparation of slow release nanopesticide microspheres from benzoyl lignin
Authors: Zhou Mingsong , Xiong Zicao , Yang Dongjie , Pang Yuxia , Wang Dongping , Qiu Xueqing 
Published: April 2018

AbstractIn this paper, benzoyl lignin (BzL) was prepared from alkali lignin (AL) by hydrophobic modification, and then nanospheres (BzLCN) were prepared by the reverse solvent method of BzL and λ-cyhalothrin (λC), while BzL served as the carrier material. BzLCN particle size was decreasing with the increasing amount of BzL reaching the minimum diameters of 90–100 nm. The emulsifier 600#further reduces the particle size to about 40 nm. The prepared BzLCN had a remarkable slow release property, while the emulsifier increased the release rate. The formation mechanism of BzLCN showed that BzL mainly contains carboxyl groups and acts as a carrier material. BzL tends to aggregate on the surface of BzLCN nanospheres and provides negative charge and contributes to maintaining its stability. The hydrophobic λC moves toward the interior of the nanospheres. The emulsifier adsorbed on the surface of BzLCN is a steric hindrance and enhances the stability of BzLCN.
Insights into the activity control of the kallikrein-related peptidase 6: small-molecule modulators and allosterism
Authors: Soualmia Feryel , Bosc Elodie , Amiri Sabrina Aït , Stratmann Dirk , Magdolen Viktor , Darmoul Dalila , Reboud-Ravaux Michèle , El Amri Chahrazade 
Published: April 2018

Abstract
The activity of kallikrein-related peptidase 6 (KLK6) is deregulated in various diseases such as cancer and neurodegenerative diseases. KLK6 is thus considered as an attractive therapeutical target. In this short report, we depict some novel findings on the regulation of the KLK6 activity. Namely, we identified mechanism-based inhibitors (suicide substrates) from an in-house library of 6-substituted coumarin-3-carboxylate derivatives. In addition, a molecular dynamics study evidenced the allosteric behavior of KLK6 similar to that previously observed for some trypsin-like serine proteases. This allosteric behavior together with the coumarinic scaffold bring new opportunities for the design of KLK6 potent activity modulators, useful as therapeutics or activity-based probes.
Neuronal RNP granules: from physiological to pathological assemblies
Authors: De Graeve Fabienne , Besse Florence 
Published: April 2018

Abstract
Neuronal cells rely on macro- and micro-cellular compartmentalization to rapidly process information, and respond locally to external stimuli. Such a cellular organization is achieved via the assembly of neuronal ribonucleoprotein (RNP) granules, dynamic membrane-less organelles enriched in RNAs and associated regulatory proteins. In this review, we discuss how these high-order structures transport mRNAs to dendrites and axons, and how they contribute to the spatio-temporal regulation of localized mRNA translation. We also highlight how recent biophysical studies have shed light on the mechanisms underlying neuronal RNP granule dynamic assembly, remodeling and maturation, in both physiological and pathological contexts.
Unwiderstehliche Horizonte? Zum konzeptionellen Wandel von Hanseraum, Reich und Europa bei Fritz Rörig und Carl Schmitt
Authors: Groth Carsten , Höhn Philipp 
Published: April 2018

Zusammenfassung
Der Artikel befasst sich mit dem Wandel von Rauminterpretationen und Europavorstellungen in der deutschen Mediävistik und dem Völkerrecht in den 1940er Jahren am Beispiel des Hansehistorikers Fritz Rörig und Carl Schmitts. Ausgehend von den Diskussionen zwischen Rörig und Schmitt um die Figur des Piraten, die aus ihrer Bekanntschaft aus dem „Kriegseinsatz der Geisteswissenschaften“ entstand, wird nach den Verschränkungen geschichtswissenschaftlicher Konzepte mit zeitpolitischen Fragestellungen gefragt. Unser Beitrag zeigt, dass die als Fragmentierung erfahrene Kriegsniederlage von 1918, der Nationalsozialismus, aber besonders die Kriegserfolge zu Beginn des Zweiten Weltkrieges für Intellektuelle wie Schmitt und Rörig katalytisch wirkten, um sich vom Nationalstaat als konstantem Bezugspunkt zu lösen und historische Phänomene mit Begriffen jenseits des Staats zu fassen. Er argumentiert, dass der Schlüssel zu diesem Wandel im relativen Raumverständnis Schmitts und Rörigs lag, nach dem Räume durch soziale Operationen konstituiert wurden. Während Schmitt mit seiner „völkerrechtlichen Großraumordnung“ überstaatliche Reiche zu Völkerrechtssubjekten aufwertete, gelangte Rörig in enger Korrespondenz zu einer Neubewertung des Verhältnisses von Raum, Reich, Hanse und Europa. An die Stelle einer national verstandenen Hanse, die Teil einer protoglobalisierten Weltwirtschaft gewesen sei, verstand er sie nun als Träger eines europäischen Großraumes. Die Vagheit dieser Konzepte ermöglichte ihre Umschreibung nach 1945. Während die Raum- und Reichskonzepte in den 1990er Jahren erst neu entdeckt wurden, setzten die sich von Rörig zur Legitimation des deutschen Eroberungskrieges vorgebrachten Ansätze, historische Phänomene wie die Hanse nicht mehr in einem nationalen, sondern spezifisch europäischen Rahmen zu fassen, nahtlos durch.
Baptisten und 1918/19. Zum Verhältnis von Freikirche und Staat in der Gründungsphase der Weimarer Republik
Authors: Baumann Imanuel 
Published: April 2018

Zusammenfassung
Nach dem Ende der Verbindung von Thron und Altar musste das Verhältnis von Kirche und Staat in Deutschland grundlegend neu geordnet werden. Welche Auswirkungen hatte das aber für die Freikirchen? Wie haben sich Freikirchen und Staatsgewalt am Anfang der Weimarer Republik zueinander positioniert, wie haben sie agiert und reagiert? Diese Fragen sollen am Beispiel einer der größten Freikirchen in Deutschland, den Baptisten, exemplarisch analysiert werden. Zunächst beleuchtet der Beitrag die Wahrnehmung von Revolution und Republik seitens des offiziellen Baptismus; in einem zweiten Schritt geht er auf die Behandlung von Freikirchen in der verfassungsgebenden Nationalversammlung ein und widmet sich schließlich, drittens, der Praxis der Verleihung von Körperschaftsrechten nach 1919. Es wird gezeigt, dass die Baptisten dem revolutionären Geschehen von 1918/19 verhalten und kritisch gegenüberstanden, sich jedoch rasch und pragmatisch auf die neuen Gegebenheiten einstellten: Nach der Verabschiedung der Weimarer Reichsverfassung bemühten sie sich intensiv um die Körperschaftsrechte. Doch die staatliche Anerkennung und vollständige rechtliche Gleichstellung mit den Landeskirchen verlief äußert schleppend. Mit dem Ende des Staatskirchentums war für die Freikirchen keine abrupte Zäsur in religionsverfassungsrechtlicher Hinsicht verbunden; es markierte vielmehr den Beginn einer längeren Entwicklung, eines Prozesses, der sich auch nach 1945 noch fortsetzte. Der Kampf der Baptisten um die Körperschaftsrechte in der Weimarer Republik kann dabei als ein Reflex auf ihre Verfolgungsgeschichte im 19. Jahrhundert gedeutet werden.
Techniker an der Macht. Der Ingenieur-Politiker im 20. Jahrhundert
Authors: Uekötter Frank 
Published: April 2018

Zusammenfassung
Der Aufsatz diskutiert, warum Ingenieure in der Zeit von 1930 bis 1970 auffallend häufig in politische Spitzenpositionen aufstiegen, obwohl sie weder zuvor noch danach in nennenswerter Zahl zur politischen Funktionselite zählten. Der Aufsatz beleuchtet in deutsch-amerikanisch vergleichender Perspektive den sozial- und professionsgeschichtlichen Kontext, den autoritären Führungsstil dieser Politiker sowie die unter ihrer Ägide rasant wachsenden Behörden. Als entscheidender Faktor für den Aufstieg präsentieren sich die Verfügbarkeit großer finanzieller Mittel für Infrastrukturprogramme im Gefolge der Weltwirtschaftskrise und die dadurch ermöglichten Bauprogramme von neuartigem Umfang und Geschwindigkeit. Bestehende Wege politischer und administrativer Kontrolle wurden durch den präzedenzlosen Arbeitstakt quasi umgangen. In der Nachkriegszeit erodierten sukzessive die Sonderbedingungen, die den Aufstieg von Ingenieuren in politische Spitzenpositionen ermöglicht hatten, so dass Infrastrukturprojekte zunehmend gesichtslos wirkten.
A converse result for Banach space convergence rates in Tikhonov-type convex regularization of ill-posed linear equations
Authors: Flemming Jens 
Published: April 2018

Abstract
We consider Tikhonov-type variational regularization of ill-posed linear operator equations in Banach spaces with general convex penalty functionals.
Upper bounds for certain error measures expressing the distance between exact and regularized solutions, especially for Bregman distances, can be obtained from variational source conditions.
We prove that such bounds are optimal in case of twisted Bregman distances, a specific a priori parameter choice, and low regularity of the exact solution, that is, the rate function is also an asymptotic lower bound for the error measure. This result extends existing converse results from Hilbert space settings to Banach spaces without adhering to spectral theory.
Dehydrogenation of alcohols and polyols from a hydrogen production perspective
Authors: Campos Jesús 
Published: April 2018

Abstract
The production of hydrogen from renewable resources is still a major challenge in our way to reach a foreseen hydrogen economy. Abstracting the hydrogen contained in alcohols by means of acceptorless dehydrogenation reactions has emerged as a viable method with high potential. This is particularly true when applied to bio-based alcohols such as ethanol, glycerol or sugars, whose hydrogen extrusion is covered in this contribution. A general overview of the development of aceptorless alcohol dehydrogenation reactions and its potential implementation into future biorefineries are discussed.
Accelerated Ageing of Parchment: Investigation of a Photo Catalysed, Low-Heat Approach
Authors: Kern Marie Sarah , Pataki-Hundt Andrea , Wouters Jan , Kirby Daniel P. 
Published: April 2018

Abstract
Accelerated ageing is an often-used tool in conservation research, yet difficult to apply to parchment due to the materials inherent heat sensitivity. The complexity of this organic material makes the analysis of its deterioration especially challenging. An attempt to develop a non-heat ageing protocol for parchment is described in this paper. The work was performed within the scope of a MA-thesis at the State Academy of Art and Design Stuttgart. Samples of a modern new limed goat parchment and pieces of reconstituted parchment made from bovine hide powder were subjected to a combination of light ageing and dynamic ageing at moderate temperatures. All samples were analysed with the goal to observe degradation on as many structural levels as possible: colour measurement via VIS spectrometry and light-microscopic observation of fibre damage were employed to assess visible changes. Shrinkage temperature (Ts) was measured as an indicator for the amount of intact intrafibrillar bonds and the determination of the maximum moisture absorption capacity gave an impression on the parchments overall level of hygroscopy. In addition, PMF (Peptid Mass Fingerprinting) via MALDI/MS TOF was performed on extracts from unaged and light aged goat parchment. The results of the different types of analysis showed significant degradation on different structural levels of the parchment, indicating that accelerated ageing of parchment that uses a combination of light and dynamic ageing may be a viable alternative to the more commonly applied thermal ageing.
New homogenization method for diffusion equations
Authors: Kuznetsov Yuri A. 
Published: April 2018

Abstract
In this paper, we propose and investigate a new homogenization method for diffusion problems in domains with multiple inclusions with large values of diffusion coefficients. The diffusion problem is approximated by the P1-finite element method on a triangular mesh. The underlying algebraic problem is replaced by a special system with a saddle point matrix. For the solution of the saddle point system we use the typical asymptotic expansion. We prove the error estimates and convergence of the expanded solutions. Numerical results confirm the theoretical conclusions.
Semi-Lagrangian difference approximations with different stability requirements
Authors: Shaidurov Vladimir V. , Vyatkin Alexander V. , Kuchunova Elena V. 
Published: April 2018

Abstract
The paper demonstrates different ways of using the semi-Lagrangian approximation depending on the fulfillment of conservation laws. A one-dimensional continuity equation and a parabolic one are taken as simple methodological examples. For these equations, the principles of constructing discrete analogues are demonstrated for three different conservation laws (or the requirements of stability in the related discrete norms similar to the L1, L2, L∞-norms). It is significant that different conservation laws yield difference problems of different types as well as different ways to justify their stability.