bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Scandinavian experience of including reproductive traits in Breeding Programmes
Authors: Lindhdé B. , Philipsson J. 
Published: May 2019

AbstractFemale fertility affects the culling rate as well as the direct reproduction costs and influences the calving interval and the calving season. It is therefore obvious that female fertility should be included in a Total Merit Index (TMI), which directs the genetic changes in dairy cattle selection. When the first TMI was introduced in Sweden in 1975 female fertility was included. A basic prerequisite for inclusion of fertility in the Scandinavian breeding programme was that milk recording, pedigree and AI-data were integrated in the same databases.The paper deals exclusively with the additive genetic effects on female fertility. The heritabilities of the measures used for female fertility are low, usually below 0.05. Despite this, the additive genetic variance is high as demonstrated by large differences between progeny groups. Thus, selection must be based on progeny testing of bulls on daughter groups of 100-150 daughters or more, which is the case in all the Scandinavian countries. Different procedures for calculation of daughter fertility indices are practised in Scandinavia.Research shows the importance of including measures of both the time interval from calving to insemination and a direct fertility trait such as number of inseminations or non-return rate (NR). It has also been shown that reproductive measures of different stages of life, i.e. heifer and lactating cow periods, must be considered. The genetic correlations between daughter fertility and different yield measures are negative (-0.2 to -0.4). Selection for yield without consideration of daughter fertility results in a deterioration of daughter fertility. A comparison of the flat genetic and phenotypic trends for daughter fertility along with strongly increased productivity in the SRB-breed, where Scandinavian bulls have dominated as sires of sons, and the negative trends in the SLB-breed where almost all sires of sons during a decade and a half have been imported from North America, illustrates the consequences of selection with and without consideration of daughter fertility in the sire-son path.Daughter fertility will probably remain an important trait in the future, not only in countries with seasonal milk production connected to the pasture period. As dairy cattle breeding is quite international, calculation of international breeding values for daughter fertility in the same way as is practised by INTERBULL for production and conformation seems to be an important challenge for the future.
Surgical Treatment of Epilepsy in Pediatric Patients
Authors: Wyllie Elaine 
Published: May 2019

ABSTRACT:Surgery has become an accepted treatment modality for carefully selected adults with intractable focal epilepsy. More recently, increasing numbers of pediatric patients with intractable epilepsy are also being referred for surgical consideration. Key elements of surgical candidacy include medically intractable focal epilepsy, a localized epileptogenic zone, and a low risk for new postoperative neurologic deficits. The most common etiologies of the epilepsies in pediatric surgical candidates are malformation of cortical development and low grade tumor but some patients with childhood onset temporal lobe epilepsy due to hippocampal sclerosis also present for early surgery. Based on results from several recent pediatric surgical series, the chance for favorable seizure outcome after surgery is not adversely affected by young age, with seizure-free postoperative outcome reported for 60% to 65% of infants, 59% to 67% of children, and 69% of adolescents, compared to 64% reported in a large, predominantly adult series. Some subgroups of patients have higher percentages of seizure-free outcome, including those with hippocampal sclerosis or low grade tumor. In addition to seizures, developmental issues are also a major concern in children with intractable epilepsy. Few quantitative data are available, but some anecdotal experience suggests that surgical relief of catastrophic epilepsy may result in resumption of developmental progression after surgery, although the rate of development often remains abnormal. In one series, best developmental outcomes were seen in patients with earliest surgery and highest level of preoperative development. For each patient, the timing of surgery must be carefully considered, based on a full assessment of the relative risks and benefits, derived from a detailed presurgical evaluation.
Diagnostic Strategies in Young Patients with Ischemic Stroke in Canada
Authors: Chan Michael T.Y. , Nadareishvili Zurab G. , Norris John W. ,   Canadian Stroke Consortium
Published: May 2019

ABSTRACT:Background:A preliminary national survey of ischemic stroke in the young (15-45 years) undertaken by the Canadian Stroke Consortium indicated that in 44% of 356 patients, no cause was found.Objective:To determine the reason for this high incidence of diagnostic uncertainty in young patients with ischemic stroke.Methods:Neurologists in the ten Canadian stroke centers completed a detailed questionnaire for patients aged 15-45 years admitted to hospital between January 1993 and December 1997. Using a step-wise diagnostic algorithm incorporating clinical, neuroimaging, neurovascular and laboratory data, we divided patients into three groups: (1) those with established cause for the ischemic stroke, (2) those who remained unexplained despite adequate investigation, (3) those who remained unexplained but were, in our opinion, under-investigated.Results:In 197 patients (56%), an identified cause was established including cardioembolic sources (14%), extracranial arterial dissection (13%), lacunar infarcts (8%) atherosclerosis (6%). A miscellaneous group of 15%, included cerebral venous thrombosis, coagulopathies, vasculitis and others. In 159 patients (44%) with no apparent cause for their stroke, we considered only 81 (23%) adequately investigated, and 78 (21%) inadequately investigated.Conclusion:About one in five young patients was inadequately investigated by a stroke-oriented group of neurologists. The major problem appears to be restriction of investigations to neuroimaging alone (usually computerized cerebral tomography), without further tests such as cerebral angiography and cardiac imaging.
Head Tremor in Cervical Dystonia
Authors: Pal P.K. , Samii A. , Schulzer M. , Mak E. , Tsui J.K.C. 
Published: May 2019

ABSTRACT:Objective:To compare the clinical characteristics, natural history, and therapeutic outcome of patients with cervical dystonia (CD) with head tremor (HT+) and without head tremor (HT-).Methods:We prospectively evaluated 114 consecutive patients of CD over a 9-month period with a detailed questionnaire. Chi-square and t-tests were employed for statistical analysis.Results:Seventy-eight (68.4%) patients had head tremor and 27 of them (34.6%) had tremor as one of the first symptoms. Age at onset of symptoms were similar in HT+ and HT- groups; however there was a higher prevalence in women in the former group (66.7% vs. 41.7%; p=0.01). HT+ patients had more frequent positive family history of essential-like hand/head tremor (21.8% vs. 5.5%; p<0.05), associated neck pain (92.3% vs. 77.8%; p<0.05), and essential-like hand tremor (40% vs. 8.3%; p<0.001). They also appeared to have more frequent history of preceding head/neck trauma (14.1% vs. 8.3%), frequent head rotation (88.5% vs. 69.4%) and antecollis (12.8% vs. 5.5%) but less often head tilt (37.2% vs. 47.2%) and gestes antagonistes (60.2% vs. 75%) than the HT- patients; however these differences were not statistically significant. The frequency of prior psychiatric illnesses, the incidence of dystonias in other parts of the body, frequency of retrocollis and shoulder elevation, and spontaneous remission were similar in the two groups.Conclusions:Head tremor is common in CD and is more commonly associated with hand tremor and family history of tremor or other movement disorders. This supports a possible genetic association between CD and essential tremor (ET). Linkage studies are required to evaluate the genetic association between CD and ET.
Intracranial Pressure Monitoring in Severe Traumatic Brain Injury – Results of a Canadian Survey
Authors: Sahjpaul Ramesh , Girotti Murray 
Published: May 2019

ABSTRACT:Objective:The purpose of this study was to obtain information from Canadian neurosurgeons regarding their opinions on, and utilization of, intracranial pressure (ICP) monitoring for severe traumatic brain injury (TBI).Methods:A brief survey was sent to practicing Canadian neurosurgeons questioning them about their utilization of, and confidence in, intracranial pressure monitoring in the management of patients with severe TBI.Results:One hundred and ninety-six surveys were mailed. There were 103 responses for a response rate of 52.6%. The vast majority of responding neurosurgeons (98.1%) utilized ICP monitoring in the management of patients with severe TBI, with most (63.4%) using it in more than 75% of their patients, 14.9% using it in 50-75% of patients, 14.9% in 25-50% of patients, and 6.9% using it in less than 25% of patients. The level of confidence that routine monitoring improves outcome from severe TBI ranged from 23.3% having a low level of confidence, 56.3% having an intermediate level of confidence, to 20.4% having a high level of confidence. Most respondents (78.6%) felt that some form of prospective trial evaluating the role of ICP monitoring in improving outcome from severe TBI was warranted; 17.4% felt such a trial was not warranted and 3.9% were uncertain.Conclusions:While ICP monitoring has gained almost universal acceptance among responding Canadian neurosurgeons, their level of confidence that routine monitoring improves outcome from severe TBI was quite variable, with only 20.4% of respondents having a high level of confidence. Over 75% of respondents felt that some form of prospective trial evaluating the utility of ICP monitoring is warranted. This information is being used in consideration of a prospective trial addressing this issue.
Modified sensory encoding during auditory hallucinations: case report and proposed mechanisms
Authors: van Sweden B. , Bryon H. , Maes M. 
Published: May 2019

SummaryA patient is presented showing an altered oddball response while suffering from auditory hallucinations. The nontarget stimulus evokes a compound negative potential encompassing a normal early N1 component and an additional negativity within the categorization N2 range. These findings are discussed in reference to impaired mismatch processes and the deranged monitoring of inner speech theory, proposed in schizophrenia.
Neural correlates of emotion processing predict resilience in youth at familial risk for mood disorders
Authors: Nimarko Akua F. , Garrett Amy S. , Carlson Gabrielle A. , Singh Manpreet K. 
Published: May 2019

AbstractAberrant face emotion processing has been demonstrated in youth with and at a familial risk for bipolar and major depressive disorders. However, the neurobiological factors related to emotion processing that underlie resilience from youth-onset mood disorders are not well understood. Functional magnetic resonance imaging data during an implicit emotion processing task were collected at baseline from a sample of 50 youth, ages 8–17, who were healthy but also familially at high risk for either bipolar disorder or major depressive disorder, and 24 healthy controls with no family history of psychopathology (HCL). Participants were reevaluated 3 years later and classified into three groups for analysis: high-risk youth who converted to a psychiatric diagnosis (CVT; N = 23), high-risk youth who were resilient from developing any psychopathology (RES; N = 27), and HCL youth (N = 24) who remained healthy at follow-up. For happy > calm faces, the CVT and RES groups had significantly lower activation in the left inferior parietal lobe (IPL), while the RES group had lower activation in the right supramarginal gyrus. For fear > calm faces, the RES group had lower activation in the right precuneus and inferior frontal gyrus (IFG) compared to the CVT group. Connectivity analyses revealed the RES group exhibited higher left IPL connectivity with visual cortical regions for happy > calm faces, and higher IFG connectivity with frontal, temporal, and limbic regions for fear > calm faces. These connectivities were correlated with improvements in prosocial behaviors and global functioning. Our findings suggest that differential activation and connectivity in the IPL, IFG, and precuneus in response to emotional stimuli may represent distinct resilience and risk markers for youth-onset mood disorders.
ACC-N-Malonyltransferase activity during zygotic embryogenesis and germination of chick-pea seeds
Authors: Martin-Remesal Clemente , Carmen Gomez-Jimenez Maria del , Matilla Angel J. 
Published: May 2019

AbstractSome physiological characteristics of ACC-Nmalonyltransferase (ACC-N-MTase) have been studied in the seeds of chick-pea (Cicer arietinum L.). This enzymatic activity was detectable during all periods of zygotic embryogenesis; however, the highest values were found in the dry seed. In dry seeds, the enzymatic activity was greater in the embryonic axis than in the cotyledons. During the onset of germination, activity increased more strongly in the cotyledons than in the embryonic axis, reaching its highest values in the storage organs coinciding with radicle emergence (18 to 24 h). Removal of the cotyledons strongly diminished enzymatic activity in the embryonic axis. Low concentrations of ethrel (50 µM) stimulated the axis ACC-N-MTase. The highest specific activity was found in the apical meristem of the embryonic axis, declining over the length of the organ. The role of ACC-N-MTase activity in the germinative process is discussed, together with the regulatory effect of ethylene on this ACCconjugating enzyme.
Evaluation of dormancy and germination responses to temperature inCarduus acanthoides and Anagallis arvensisusing a screening system, and relationship with field-observed emergence patterns
Authors: Kruk Betina C. , Benech-Arnold Roberto L. 
Published: May 2019

AbstractExperiments on the facultative winter annuals Carduus acanthoides and Anagallis arvensis were performed: (i) to determine thermal conditions that induce or release dormancy, (ii) to investigate to what extent changes in dormancy level resulting from those thermal conditions explain the seasonal pattern of emergence of these species, and (iii) to estimate required thermal time and base temperature for the germination of non-dormant seeds. Carduus acanthoides required high temperatures followed by decreasing temperatures for dormancy release; however, low winter temperatures did not induce secondary dormancy as expected for a winter annual. To the contrary, low temperatures stimulated dormancy release in the long term. InA. arvensis, dormancy relief was enhanced by dry storage at 25°C, and the response to low temperature was different depending on moisture conditions. Prolonged exposure to moist-chilling increased the dormancy level of the population, while dry storage at 4°C relieved dormancy. For both species, changes in the thermal range permissive for germination as a result of dormancy modifications explained to a large extent the timing of the emergence periods observed in the field. In neither species did base temperature for germination change with the dormancy level of the population. Thermal time required forgermination ofC. acanthoidesvaried with dormancy, while forA. arvensisseeds it was constant.
Sugarbeet seed priming: solubilization of the basic subunit of 11-S globulin in individual seeds
Authors: Bourgne Sophie , Job Claudette , Job Dominique 
Published: May 2019

AbstractPriming of sugarbeet (Beta vulgarisL.) seeds induces increased solubilization of the basic B-subunit of 11-S globulin (a major seed storage protein in sugarbeet). Using a sensitive single-seed ELISA, the soluble and total B-subunit contents of individual untreated and primed sugarbeet seeds were measured. With the untreated seeds, there was a 160-fold range of the soluble B-subunit content among individual seeds. The individual primed seeds also exhibited large variations in their soluble B-subunit content, yet only over a five-fold range. Furthermore, the frequency distributions of soluble B-subunit content were markedly different for the primed and untreated seed populations; the primed seed population exhibited a substantially higher median than that for the untreated seed population. In marked contrast, and as expected from results with pooled seed samples, the distributions of total B-subunit content were superimposed when comparing untreated and primed seed populations.
Seed dormancy in red rice (Oryza sativa). XI. Commercial liquid smoke elicits germination
Authors: Doherty Lucia C. , Cohn Marc Alan 
Published: May 2019

AbstractA commercial liquid smoke (LS) flavoring product (Reese Hickory brand) in aqueous dilutions of 4–5% (v/v) broke dormancy (40–100% germination) of both intact and dehulled red rice (Oryza sativa). To elicit this response in intact grains, the glumes had to be pricked with a dissecting needle following contact with LS and water rinsing. Germination percentages rose with increasing contact time (up to 7 d), and grains first imbibed with water before transfer to LS showed similar germination percentages as those first incubated with LS before transfer to water. LS dilutions were highly acidic (about pH 3). Dormancy-breaking activity of LS was pH-dependent and was reduced at pH values of 5–7. Buffer controls remained dormant irrespective of pH value. Maximum activity varied primarily among different bottles of LS and only to a minor extent between red rice seed lots. Dry-afterripening at 30°C for up to 14 d increased the sensitivity of unpricked, intact grains to LS compared with water controls. LS concentrations that broke dormancy of intact grains partially inhibited germination of nondormant, fully afterripened grains. Storing grains in containers of flooded soil increased sensitivity to both LS and pricking. Nitrite levels in LS were negligible and insufficient to account for the bioactivity of LS.
Uses and users of water in Bilbao, c. 1890–1910: a social-spatial analysis
Authors: Novo Pedro A. , Zarraga Karmele 
Published: May 2019

AbstractThe article analyses the characteristics of the public water service in the city of Bilbao between the end of the nineteenth century and the beginning of the twentieth century. It addresses both the study of potable water and the different uses of non-potable water. In addition, the article includes the relationship between the water supply and the population that receives it. We are interested in knowing who enjoyed it at home, linking demographic sources with records of the water service of the city.
Looking After Children in Barnardos Australia: A study of the early stages of implementation
Authors: Dixon Deirdre 
Published: May 2019

Looking After Children (LAC), a case management system for children in out-of-home care, has been the subject of pilot implementation in several Australian states. Barnardos Australia, in association with the University of NSW, implemented LAC in all of its out-of-home care programs as part of an Australian Research Council (ARC) research grant, in 1997–99.This study looks at the factors affecting implementation of Looking After Children in Barnardos Australia out-of-home care programs during the initial twelve month period (1997–98). Information collected from interviews with eleven program managers, and examination of records containing LAC material on casework files, are used to explore factors which assisted or impeded LAC implementation. Similarities are highlighted between UK and Australian experiences of LAC implementation, and issues are raised of significance to agencies considering using LAC.
The influence of non-genetic factors on the shape of lactation curves in Red Sokoto goats
Authors: Akpa G. N. , Asiribo E.O. , Oni O. O. , Alawa J. P. 
Published: May 2019

AbstractMilk yields of 66 nursing does recorded in Zaria, Nigeria were used to characterize the lactation curve and study the influencing factors in Red Sokoto goats. Lactation curve parameters obtained by fitting the model: Yt = atbe –ct were subjected to statistical analysis, using herd, season, parity, litter size and litter composition of dams.The results indicate that the lactation curve of these goats was characterized by milk production increasing in early lactation, attaining a peak at approximately 2 to 5 weeks post partum and thereafter declining slowly to the end of lactation. The observed total yield, peak yield, peak day and the estimated persistency defined as c–( b + 1) was 79·3 kg, 1·2 kg, 20·5 and 143·2, respectively. Parameters ‘ a‘ and ‘ c‘ were strongly but negatively correlated ( r = –0·53; P < 0·01). The curve parameters ‘ a‘ and ‘ c‘ differed by herd and season ( P < 0·05); and parity only affected ( P < 0·01) parameter ‘ a‘. None of the factors significantly influenced parameter ‘ b‘ ( P > 0·05).The significant herd and season effects may have practical implications in determining optimal feeding management and season of breeding to maximize total lactation yield.
Evaluation of extent and amount of heterogeneous variance for milk yield in Uruguayan Holsteins
Authors: Urioste J. I. , Gianola D. , Rekaya R. , Fikse W. F. , K. A. Weigel  
Published: May 2019

AbstractThe extent and amount of heterogeneous phenotypic variance for milk yield in the Uruguayan Holstein population were evaluated and a simple method of accounting for heterogeneity was developed. Lactation records (159 169) collected between 1989 and 1998 by two recording schemes were used to form 8955 herd-year-season-parity-lactation length contemporary groups. A log-linear model was used to identify factors affecting heterogeneity of phenotypic variance. The model included effects of production level, contemporary group size, recording scheme, herd, season of calving, parity number, calving year period and length of lactation and accounted for 50% of the variation in log variances. Estimates from this model were used in a Bayesian manner, to obtain posterior mean estimates of within-contemporary-group variances, which were then used to standardize records to a baseline variance. Effects of the adjustment were assessed by comparing coefficients of variation before and after correction, by correlation and regression between mean and standard deviations, and by using Gini coefficients and Lorenz curves. The adjustment procedure reduced heteroscedasticity primarily by decreasing the frequency of low-variance contemporary groups. Lorenz curves and Gini coefficients indicated that the largest impact of the standardization procedure was related to the size of the contemporary group. Some differences in the effect of the correction were found between recording schemes. The method for adjusting records is simple and easy to adapt to current genetic evaluation procedures.