bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results on t-Fuzzy Graphs
Authors: Borzooei R. A. , Sheikh Hoseini B. , Mohseni Takallo M. 
Published: September 2019

It is much more practical to use the [Formula: see text]-norm than the minimum in defining the fuzzy graph. Hence, the concept of [Formula: see text]-fuzzy graph was introduced by Mordeson et al. in [J. N. Mordeson and S. Mathew, [Formula: see text]-norm Fuzzy Graphs, New Mathematics and Natural Computation 14(1) (2018) 129–143]. In this paper, we concentrate on the relatively new concept of fuzzy adjacency matrix of that [Formula: see text]-fuzzy graphs. The purpose of this paper is to further develop a product of this fuzzy adjacency matrix based on [Formula: see text]-fuzzy graphs. Moreover, two kinds of Boolean matrix are defined and relation between Normal Boolean matrix, product of adjacency matrix and 1-level cut Boolean matrix is obtained.
A new exploration tool for subtle stratigraphic traps in the offshore Nile Delta, Egypt
Authors: Lala Amir M. S. , Talaat Amr 
Published: September 2019

The offshore Nile Delta Basin is considered as one of the most promising hydrocarbon provinces in Egypt, with an excellent potential for gas and condensate reserves following future exploration. Most of the discoveries in this basin, such as the reservoirs of the Upper Miocene and the Middle–Upper Pliocene, have been enabled by the use of a direct hydrocarbon indicator (DHI), based on a class III seismic amplitude v. offset (AVO) anomaly. However, there are gas-bearing formations in the Lower Pliocene that have been successfully tested where the sand did not show any seismic amplitude anomaly in full stacks or in near- and far-offset sub-stacks. The AVO analysis of this sand reservoir is referred to as AVO class II-P. Another case of a subtle AVO class I anomaly in a Lower Pliocene gas reservoir has also been tested by three wells.
These variations in AVO types push us to find a new methodology to reduce the risk of unsuccessful exploration wells, mainly using seismic data. The enhanced AVO pseudo-gradient attribute (EAP) has previously been used in other studies, mainly to highlight AVO class III anomalies. However, in the present paper, we demonstrate a workflow to identify all the principal AVO classes observed in this province. Computing the EAP attribute from our data, we find that AVO class I has negative EAP values, while the other classes have positive values. Class III and classes II and II-P may be distinguished from each other as the former yields a strong positive EAP value, whereas the latter two classes yield weak EAP responses.
After determining the AVO class, we define and use a new model attribute, herein termed NM, to differentiate between gas- and water-bearing formations for each class of AVO anomaly found in this province. This new method was successfully tested in many areas in the Nile Delta Basin, where it has helped to identify subtle anomalies and thereby open the gate for further exploration activities in the area.
Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS–Dependent Pancreatic Ductal Adenocarcinoma
Authors: Mottini Carla , Tomihara Hideo , Carrella Diego , Lamolinara Alessia , Iezzi Manuela , Huang Justin K. , Amoreo Carla A. , Buglioni Simonetta , Manni Isabella , Robinson Frederick S. , Minelli Rosalba , Kang Ya'an , Fleming Jason B. , Kim Michael P. , Bristow Christopher A. , Trisciuoglio Daniela , Iuliano Antonella , Del Bufalo Donatella , Di Bernardo Diego , Melisi Davide , Draetta Giulio F. , Ciliberto Gennaro , Carugo Alessandro , Cardone Luca 
Published: September 2019

Abstract

Mutated KRAS protein is a pivotal tumor driver in pancreatic cancer. However, despite comprehensive efforts, effective therapeutics that can target oncogenic KRAS are still under investigation or awaiting clinical approval. Using a specific KRAS–dependent gene signature, we implemented a computer-assisted inspection of a drug–gene network to in silico repurpose drugs that work like inhibitors of oncogenic KRAS. We identified and validated decitabine, an FDA-approved drug, as a potent inhibitor of growth in pancreatic cancer cells and patient-derived xenograft models that showed KRAS dependency. Mechanistically, decitabine efficacy was linked to KRAS–driven dependency on nucleotide metabolism and its ability to specifically impair pyrimidine biosynthesis in KRAS–dependent tumors cells. These findings also showed that gene signatures related to KRAS dependency might be prospectively used to inform on decitabine sensitivity in a selected subset of patients with KRAS–mutated pancreatic cancer. Overall, the repurposing of decitabine emerged as an intriguing option for treating pancreatic tumors that are addicted to mutant KRAS, thus offering opportunities for improving the arsenal of therapeutics for this extremely deadly disease.

Significance:
Decitabine is a promising drug for cancer cells dependent on RAS signaling.
Germline BRCA-Associated Endometrial Carcinoma Is a Distinct Clinicopathologic Entity
Authors: de Jonge Marthe M. , Ritterhouse Lauren L. , de Kroon Cornelis D. , Vreeswijk Maaike P.G. , Segal Jeremy P. , Puranik Rutika , Hollema Harry , Rookus Matti A. , van Asperen Christi J. , van Leeuwen Flora E. , Smit Vincent T.H.B.M. , Howitt Brooke E. , Bosse Tjalling 
Published: September 2019

Abstract

Purpose:
Whether endometrial carcinoma (EC) should be considered part of the gBRCA1/2-associated hereditary breast and ovarian cancer (HBOC) syndrome is topic of debate. We sought to assess whether ECs occurring in gBRCA carriers are enriched for clinicopathologic and molecular characteristics, thereby supporting a causal relationship.

Experimental Design:
Thirty-eight gBRCA carriers that developed EC were selected from the nationwide cohort study on hereditary breast and ovarian cancer in the Netherlands (HEBON), and these were supplemented with four institutional cases. Tumor tissue was retrieved via PALGA (Dutch Pathology Registry). Nineteen morphologic features were scored and histotype was determined by three expert gynecologic pathologists, blinded for molecular analyses (UCM-OncoPlus Assay including 1213 genes). ECs with LOH of the gBRCA-wild-type allele (gBRCA/LOHpos) were defined “gBRCA-associated,” those without LOH (gBRCA/LOHneg) were defined “sporadic.”

Results:
LOH could be assessed for 40 ECs (30 gBRCA1, 10 gBRCA2), of which 60% were gBRCA/LOHpos. gBRCA/LOHpos ECs were more frequently of nonendometrioid (58%, P = 0.001) and grade 3 histology (79%, P &lt; 0.001). All but two were in the TP53-mutated TCGA-subgroup (91.7%, P &lt; 0.001). In contrast, gBRCA/LOHneg ECs were mainly grade 1 endometrioid EC (94%) and showed a more heterogeneous distribution of TCGA-molecular subgroups: POLE-mutated (6.3%), MSI-high (25%), NSMP (62.5%), and TP53-mutated (6.3%).

Conclusions:
We provide novel evidence in favor of EC being part of the gBRCA-associated HBOC-syndrome. gBRCA-associated ECs are enriched for EC subtypes associated with unfavorable clinical outcome. These findings have profound therapeutic consequences as these patients may benefit from treatment strategies such as PARP inhibitors. In addition, it should influence counseling and surveillance of gBRCA carriers.
Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer
Authors: Ponz-Sarvise Mariano , Corbo Vincenzo , Tiriac Hervé , Engle Dannielle D. , Frese Kristopher K. , Oni Tobiloba E. , Hwang Chang-Il , Öhlund Daniel , Chio Iok In Christine , Baker Lindsey A. , Filippini Dea , Wright Kevin , Bapiro Tashinga E. , Huang Pearl , Smith Paul , Yu Kenneth H. , Jodrell Duncan I. , Park Youngkyu , Tuveson David A. 
Published: September 2019

AbstractPurpose:KRAS is mutated in the majority of pancreatic ductal adenocarcinoma. MAPK and PI3K-AKT are primary KRAS effector pathways, but combined MAPK and PI3K inhibition has not been demonstrated to be clinically effective to date. We explore the resistance mechanisms uniquely employed by malignant cells.Experimental Design:We evaluated the expression and activation of receptor tyrosine kinases in response to combined MEK and AKT inhibition in KPC mice and pancreatic ductal organoids. In addition, we sought to determine the therapeutic efficacy of targeting resistance pathways induced by MEK and AKT inhibition in order to identify malignant-specific vulnerabilities.Results:Combined MEK and AKT inhibition modestly extended the survival of KPC mice and increased Egfr and ErbB2 phosphorylation levels. Tumor organoids, but not their normal counterparts, exhibited elevated phosphorylation of ERBB2 and ERBB3 after MEK and AKT blockade. A pan-ERBB inhibitor synergized with MEK and AKT blockade in human PDA organoids, whereas this was not observed for the EGFR inhibitor erlotinib. Combined MEK and ERBB inhibitor treatment of human organoid orthotopic xenografts was sufficient to cause tumor regression in short-term intervention studies.Conclusions:Analyses of normal and tumor pancreatic organoids revealed the importance of ERBB activation during MEK and AKT blockade primarily in the malignant cultures. The lack of ERBB hyperactivation in normal organoids suggests a larger therapeutic index. In our models, pan-ERBB inhibition was synergistic with dual inhibition of MEK and AKT, and the combination of a pan-ERBB inhibitor with MEK antagonists showed the highest activity both in vitro and in vivo.
Prognostic Value of Coronary Microvascular Function Measured Immediately After Percutaneous Coronary Intervention in Stable Coronary Artery Disease
Authors: Nishi Takeshi , Murai Tadashi , Ciccarelli Giovanni , Shah Sonia V. , Kobayashi Yuhei , Derimay François , Waseda Katsuhisa , Moonen Avalon , Hoshino Masahiro , Hirohata Atsushi , Yong Andy S.C. , Ng Martin K.C. , Amano Tetsuya , Barbato Emanuele , Kakuta Tsunekazu , Fearon William F. 
Published: September 2019

Background:
The prognostic impact of coronary microvascular dysfunction after percutaneous coronary intervention (PCI) remains unclear in patients with stable coronary artery disease. This study sought to investigate the prognostic value of microvascular function measured immediately after PCI in patients with stable coronary artery disease.

Methods:
We enrolled 572 patients with stable coronary artery disease who underwent PCI and elective measurement of the index of microcirculatory resistance (IMR) immediately after PCI from 8 centers in 4 countries. Impaired microvascular function was defined as IMR≥25 (high IMR). Major adverse cardiac events, including death, myocardial infarction (MI) and target vessel revascularization, were evaluated.

Results:

During a median follow-up duration of 4.0 years, the cumulative major adverse cardiac events rate was significantly higher in the high IMR group (n=66/148) compared with the low IMR group (n=128/424; hazard ratio [HR], 1.56; 95% CI, 1.16−2.105;
P
=0.001), primarily due to a higher rate of periprocedural MI (HR, 1.59; 95% CI, 1.11−2.28;
P
=0.004) but also due to higher rates of mortality (HR, 1.59; 95% CI, 0.76−3.35;
P
=0.22), spontaneous MI (HR, 2.10; 95% CI, 0.67−6.63;
P
=0.20) and target vessel revascularization (HR, 1.40; 95% CI, 0.77−2.54;
P
=0.27). Cumulative risk for death, spontaneous MI, and target vessel revascularization was higher in the high IMR group (HR, 1.55; 95% CI, 0.99−2.43;
P
=0.056), as was death and spontaneous MI alone (HR, 1.79; 95% CI, 0.96−3.36;
P
=0.065). On multivariable analysis, high IMR post-PCI was an independent predictor of major adverse cardiac events.

Conclusions:
IMR measured immediately after PCI predicts adverse events in patients with stable coronary artery disease.
The wounds of childhood: Early trauma subtypes, salience and hyperarousal in a sample of adult psychiatric patients
Authors: Muscatello Maria Rosaria Anna , Rizzo Amelia , Celebre Laura , Mento Carmela , Pandolfo Gianluca , Cedro Clemente , Battaglia Fortunato , Zoccali Rocco Antonio , Bruno Antonio 
Published: September 2019

Background: The relationship between early trauma, hyperarousal and aberrant salience has been investigated exclusively in specific clinical samples, such as post-traumatic stress disorder (PTSD) and psychotic patients, and the results suggest that both dimensions are trauma-induced events, which may lead to the later onset, or increase the vulnerability to psychiatric disorders. The aim of the present research was to evaluate the possible relationships among early childhood trauma subtypes and the dimensions of hyperarousal and aberrant salience in an adult sample of psychiatric patients. Materials and Methods: One-hundred psychiatric adult outpatients were assessed by Early Trauma Inventory Self Report-Short Form (ETISR-SF), Aberrant Salience Inventory (ASI) and Hyperarousal Scale (H-Scale). A linear regression analysis was performed in order to investigate which early traumatic events were a predictor of the aberrant salience and the hyperarousal. Results: Regression analysis indicated that only ETISR-SF ‘Emotional abuse’ was the unique predictor of ASI ‘Total score’ ( p < .0001) and H-Scale ‘Total score’ ( p = .031), whereas other ETISR-SF variables did not give a significant additional contribution to the prediction of aberrant salience and the hyperarousal dimension. Conclusions: These findings support the role of emotional abuse as predictor of hyperarousal, a basic dimension associated with general vulnerability to mental illness. The awareness of the psychiatric consequences of early childhood trauma leads us to consider the need for better identification of children at risk, to develop effective interventions for the protection of minors from violent and/or inappropriate behaviors and to promote the development of protective resilience factors against re-victimization.
Beyond Neo-liberalism: Analyzing the ‘Post-Developmental State’ in South Korea
Authors: Uttam Jitendra 
Published: September 2019

After painful reform and restructuring of post-1997 financial crisis, many scholars equated South Korea’s ‘post-developmental state’ with neo-liberal state. However, in doing so, they ignored South Korea’s lasting legacy of interventionist ‘developmental state’ that led nation’s miraculous transformation from a poor agrarian society to a prosperous industrial economy. This article stresses that South Korea indeed tried to adopt some of the policy prescriptions suggested by neo-liberal ideas but moving beyond the dictates of neo-liberalism it also strengthened state capacity to augment non-market mechanisms. The article argues that South Korea’s post-developmental state moved into two non-market spheres; First, by tilting towards becoming a ‘techno-scientific state’ and second, it attempted to reimaging South Korea by leaning to develop into a ‘Brand state’. Both non-market initiatives moved South Korea ‘beyond neo-liberalism’ and invoked its ‘statist developmental’ past guided by Keynesian economics. South Korea’s reach to incorporate market and non-market dictates has invited terms such as ‘liberal developmentalism’, a hybrid system where state used its enhanced capacity to improve the efficiency of market system.
Case–control evaluation of the impact of below 20 mmHg elastic compression stockings on lower limb volume serial variations in standardized flights
Authors: Gianesini Sergio , Mosti Giovanni , Raffetto Joseph D , Maietti Elisa , Chi Yung-Wei , Tangerini Luca , Menegatti Erica 
Published: September 2019

Background Graduated compression stocking (GCS) use during flights demonstrated to positively impact leg oedema. Nevertheless, these data were collected in a single flight, mainly at the ankle, and using greater than 20 mmHg GCS. This investigation reports data from 16 flights in which the same passenger’s leg circumferences variation were assessed wearing non-graduated ankle-sock or a below-knee 15–20 mmHg GCS. Methods The limb was divided by the circumferences in eight sectors, every 4 cm, labelled from 1 to 8, starting from the ankle up. The assessment was done at the take-off and after a 4-h flight time, for a total of 16 flights. The subject used non-graduated ankle socks (elastic band at 4 cm from B-point) during the outgoing flight and below-knee GCS (15–20 mmHg) during the return flight. Interface pressure was assessed at the ankle point of minimum girth (B) and ascending proximally every 4 cm (B+cm) for the GCS, and at B and at the elastic band level (B + 4 cm) for the sock. Results GCS interface pressure was 13.3 ± 2.5 mmHg in B and 18.1 ± 2.4 mmHg in B + 4 cm. The sock interface pressure was 3.1 ± 0.7 mmHg in B and 8.1 ± 0.9 mmHg at the band level (B + 4 cm). Socks led to a significant total volume increase (117.3 ± 25.8 mL; 5.2% ±1.1%; P < 0.0001). GCS led to a non-significant total volume decrease (–3.1 ± 14.4 mL; –0.1 ± 0.6%; P = 0.3964) and did not allow for volume increase. The different sectors showed a heterogeneous volume variation, not following a precisely graduated or progressive compression profile. Conclusions Leg oedema following a 4-h flight is controlled by <20 mmHg GCS. Leg fluids, with and without GCS, are mobilized in a non-graduated profile from the ankle to the knee after prolonged sitting on a plane.
Which pressure of adjustable compression wrap system is necessary to reduce deep vein cross section area in post-thrombotic patients? A proof-of-concept study
Authors: Szary Cezary , Wilczko Justyna , Grzela Tomasz , Partsch Hugo 
Published: September 2019

Objective The conservative treatment of post-thrombotic syndrome includes application of compression on the affected extremity. However, the type and the level of compression required to manage post-thrombotic syndrome are still unclear. The aim of our proof-of-concept study was to assess the compression required to reduce cross section area of post-thrombotic deep veins in 22 patients with post-thrombotic syndrome. Methods The circumference and cross section area of posterior tibial veins and saphenous vein trunk were assessed on mid-calf level using 3T magnetic resonance scanner, at increasing compression (0, 30, 40, and 50 mmHg), provided by a novel adjustable Velcro compression wrap, the CircAid JuxtaLite®. Results A significant reduction of baseline vein cross section area in post-thrombotic syndrome patients in the lying position required compression of at least 30 mmHg for posterior tibial veins, and at least 40 mmHg for the saphenous trunk. Apart from morphological changes of the compressed veins, we observed extinction of T2w signal at compression above 40 mmHg, which corresponded to accelerated blood flow in the veins, and therefore may be considered as a hemodynamic marker of compression effectiveness. Conclusion CircAid adjusted to compression level ≥40 mmHg accelerates blood flow in affected deep veins, thus it may facilitate post-thrombotic syndrome management.
Comparison of ramosetron and ondansetron for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery: a meta-analysis of randomized controlled trials
Authors: Li Yiping , Deng Ruiming , Zhou Juan , Chen Yuan , Ouyang Aiping 
Published: September 2019

Objective We conducted a systematic literature search and meta-analysis to identify randomized controlled trials (RCTs) comparing the efficacy and safety of ramosetron versus ondansetron for the prevention of postoperative nausea and vomiting (PONV; PON and POV, respectively) in patients undergoing laparoscopic surgery. Methods The electronic databases PubMed, EMBASE, Web of Science, and Cochrane Library were searched up to March 2019 to identify relevant studies. Results The final pooled analysis included 6 RCTs and revealed that postoperative treatment with ramosetron at 24 to 48 hours after surgery significantly reduced the incidence of PON and POV relative to treatment with ondansetron. In a subgroup analysis, ramosetron 0.3 mg tended to reduce PON (0–2 hours) and POV (24–48 hours) more effectively than ondansetron 4 mg. However, no statistical difference was observed between ramosetron 0.3 mg and ondansetron 8 mg in terms of the reduction of PON or POV during any time interval within the first 48 hours after surgery. Conclusions Our results indicate that ramosetron 0.3 mg is superior to ondansetron 4 mg and comparable to ondansetron 8 mg for PONV prophylaxis after laparoscopic surgery.
A novel serum: Electrophoresis method to prepare acellular corneal matrix as an artificial corneal scaffold
Authors: Li Qing , Xie Cuicui , Wang Hongmei , Zhang Fenghua , Mu Lanlan 
Published: September 2019

Introduction: The aim of this study was to develop a novel decellularization method in order to obtain an ideal scaffold with good biocompatibility. Methods: The porcine corneas were treated with human serum for 5 days or serum-electrophoresis respectively. The electrophoresis (100 V/cm) was performed in sterilized buffer containing 40-mM tris base, 18-mM glacial acetic acid, and antibiotics for 1 h at 4°C. The properties of artificial corneal scaffolds were characterized by morphological and histological examinations. The biocompatibility and biological safety were examined by subcutaneous implant test and lamellar keratoplasty. Results and conclusions: The transparency and appearance of serum-electrophoresis acellular porcine corneal matrix were better than serum acellular porcine corneal matrix. DNA and α-gal in serum-electrophoresis acellular porcine corneal matrix were more efficiently removed than those in serum acellular porcine corneal matrix (p < 0.05). The subcutaneous and corneal implantation experiments showed serum-electrophoresis acellular porcine corneal matrix had better biocompatibility compared to serum acellular porcine corneal matrix (p < 0.01). This novel serum-electrophoresis decellularization method may be valuable for preparation of xenogenic corneal tissue for clinical application.
Do Teacher Credentials and Characteristics Affect Teacher Effectiveness in High School Economics?
Authors: Swinton John R. , Clark Chris 
Published: September 2019

We use student-level administrative data from Georgia to examine how teacher characteristics affect student learning. Specifically, we examine students’ normalized end-of-course test scores for a required high school economics course. We develop two models. First, we examine returns to activities often linked to teacher effectiveness—experience, advanced degrees, National Board Certification, and curriculum-specific in-service workshops. Second, we investigate the importance of having teachers share characteristics with their students. Similar to many studies before us, we find little systematic link between any of the observable teacher characteristics and better student outcomes once we control for unobservable teacher characteristics. Of note, we do find that female students tend to perform better with female teachers than with male teachers. Overall, the results highlight the difficulty in relying on just one specific measure of teacher quality to ensure student performance. JEL Classifications: A13, A21, I24