bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early bi-canalicular silicone stent intubation in failed DCR with endoscopic visualization: a combined approach
Authors: Sreenivas V. , Chaitanya P. , Reddy Manjoo 
Published: April 2019

<p class="abstract"><strong>Background:</strong> Chronic dacryosystitis is a common condition affecting the eye and presenting to ENT surgeons and ophthalmologists, and treated with DCR (dacryocystorhinostomy). In few cases there can be recurrence of symptoms following DCR surgery which can be treated with bi-canalicular silicone intubation. The aim of this study is to assess the effectiveness of an early bi-canalicular silicone intubation in patients with failed DCR using endoscopic visualisation.</p><p class="abstract"><strong>Methods:</strong> This was a prospective observational study. Thirteen cases of DCR operated for chronic dacryocystitis at St John’s Medical College Hospital were reviewed between January 2014 and February 2017. Endoscopic DCR was done for five patients and external DCR for eight patients, number of males were 5 (38%) and females were 8 (62%). Age: 9–73 years (avg: 40.5 years). </p><p class="abstract"><strong>Results:</strong> Nine patients had complete resolution of symptoms following the primary DCR (4 following external DCR and 5 following endonasal endoscopic DCR). Four patients had failed DCR with persistence of watering three months following primary DCR surgery. Re-DCR with bi - canalicular silicon stent intubation was done in failed cases. Postoperative follow up of all the four patients showed complete resolution of symptoms.</p><p class="abstract"><strong>Conclusions:</strong> Failed DCR surgeries can be effectively intubated using bi–canlicular silicon tubes in the early postoperative period following DCR surgery. Silicone tube intubation is the most safe and cost effective method. Endoscopic visualization gives an added advantage of localizing the cause for a failed DCR.</p>
Sahil Kuşağında ICARDA-CIMMYT Ekmeklik Buğday Genotiplerinin Verim ve Bazı Kalite Özellikleri Yönünden Karşılaştırılması
Authors: Koç Ali , Akgün İlknur 
Published: April 2019

Bu
çalışmada, ekmeklik buğdayın yurt dışı kaynaklı (ICARDA ve CIMMYT) 16 genotipi ile 4 kontrol çeşit (Pandas,
Karatopak, Adana 99 ve Koç 2015) verim ve bazı kalite özellikleri (glüten,
sedimentasyon ve ham protein) yönünden karşılaştırılmıştır. Araştırma, Antalya
ekolojik koşullarında iki lokasyonda (Manavgat ve Aksu) tesadüf blokları deneme
desenine göre m2’ye 500 tohum hesabıyla 4 tekrarlamalı olarak
yürütülmüştür. Ekimle birlikte 30 kg/da kompoze
(6 kg N ve 6 kg/da P2O) ve sapa kalkma döneminde 30 kg/da
amonyum nitrat (9.9 kg/da saf N) gübreleri uygulanmıştır. Araştırma sonucunda
incelenen tüm özelliklerde genotipin etkisinin önemli olduğu belirlenmiştir.
Lokasyonların etkisi ise tane verimi üzerine önemli iken, glüten, sedimentasyon
ve ham protein oranına önemsiz bulunmuştur. Genotiplere göre tane verimi 722.60-1003.30
kg/da, glüten içeriği % 25.16-37.11; sedimantasyon değeri 25.50-45.25 ml ve ham
protein oranı %11.42-14.04 arasında değişmiştir. Sonuç olarak, bazı hatların
kontrol olarak kullanılan çeşitlerden üstün olduğu belirlenmiştir. Özellikle
tane verimi yönünden 11 (1003.30 kg/da) ve 3 (1003.13 kg/da) nolu genotipler,
protein oranı yönünden ise 15 nolu genotip ( %14.04) tescil için önerilmiştir.
Aktivitas Antibakteri Minyak Atsiri Kulit Jeruk Siam Banjar (Citrus reticulata) Terhadap Pertumbuhan Pseudomonas aeruginosa
Authors: Febrianti Dwi Rizki , Susanto Yugo , Niah Rakhmadhan , Latifah Siti 
Published: April 2019

ABSTRAK Jeruk siam yang berkembang di Kalimantan Selatan telah dikukuhkan menjadi varietas unggul nasional dengan nama jeruk siam Banjar. Kulit jeruk belum dimanfaatkan secara optimal hanya dibuang sebagai limbah. Kulit jeruk mengandung beberapa senyawa salah satunya mengandung senyawa aktif minyak atsiri. Tujuan penelitian ini adalah untuk mengetahui adanya aktivitas antibakteri minyak atsiri kulit jeruk siam Banjar (Citrus reticulata) terhadap pertumbuhan Pseudomonas aeruginosa. metode penarikan minyak atsiri kulit jeruk siam Banjar menggunakan metode destilasi air. Uji aktivitas antibakteri dilakukan dengan menggunakan metode difusi cakram terhadap bakteri Pseudomonas aeruginosa. Hasil penelitian menunjukkan bahwa minyak atsiri kulit jeruk siam Banjar diperoleh sebanyak 10 mL (0,58%), berwarna kuning, aroma khas jeruk, bentuk cair, rasa getir dan tidak ada noda transparan. Hasil penelitian uji aktivitas menunjukkan minyak atsiri kulit jeruk siam Banjar dapat menghambat pertumbuhan bakteri Pseudomonas aeruginosa. Pada volume 50 µL, 75 µL, dan 100 µL minyak atsiri kontrol positif (ciprofloxacin) sedangkan kontrol negatif (aqua pro injection). diameter zona bening disekitar cakam dengan rata-rata diameter zona hambat yang dihasilkan beturut-turut 3,55 mm, 4,54 mm, 5,14 mm, 22,38 mm, dan 0 mm. Kata kunci: Kulit jeruk siam Banjar (Citrus reticulata), Minyak atsiri, Pseudomonas aeruginosa. ABSTRACT Jeruk siam that develop in South Kalimantan have been confirmed as national superior varieties by the name of jeruk siam banjars. Citrus skin has not been used optimally only as waste. Orange peel contains several compounds, one of which contains active compounds of essential oils. The purpose of this study was to determine the antibacterial activity of essential oils of jerk siam banjars skin (Citrus reticulata) to the growth of Pseudomonas aeruginosa. method of withdrawal of jeruk siam banjars essential oil using a water distillation method. Antibacterial activity test was carried out using the disc diffusion method against the bacterium Pseudomonas aeruginosa. The results showed that 10 mL (0.58%) of essential oil from the jeruk siam banjars, yellow, orange aroma, liquid form, bitter taste, and no transparent stains. The results of the activity test showed that the essential oil of the skin of the jeruk siam banjars could inhibit the growth of the bacterium Pseudomonas aeruginosa. At the volume of 50 µL, 75 µL, and 100 µL of essential oil control positive (ciprofloxacin) while the negative control (aqua pro injection). the diameter of the clear zone around the paper disk with the average diameter of the inhibition zone produced was 3.55 mm, 4.54 mm, 5.14 mm, 22.38 mm and 0 mm respectively.Keywords: jeruk siam banjar (Citrus reticulata), essential oil, Pseudomonas aeruginosa.
Review: Aktivitas Farmakologi Dan Perkembangan Produk Dari Lidah Buaya (Aloe vera L.)
Authors: Kurnia Dian , Ratnapuri Prima Happy 
Published: April 2019

ABSTRAK Lidah buaya (Aloe vera L.) diketahui mengandung banyak senyawa kimia alami, seperti antrakuinon, asam amino, acemannan, aloesin, glukomanan yang bertanggungjawab memberikan efek teraupetik yang bermanfaat dalam dunia farmasi. Review ini bertujuan untuk memberikan informasi terkait aktivitas farmakologi dan perkembangan produk dari lidah buaya dalam bidang farmasi. Pada Review artikel ini data yang disajikan diperoleh dari literatur online berupa jurnal dan artikel ilmiah publikasi lokal maupun internasional dan literatur offline berupa buku dan ­e-book. Diketahui bahwa lidah buaya memiliki berbagai aktivitas farmakologi yaitu sebagai antiinflamasi, berperan dalam penyembuhan luka, antibakteri, antifungi, antivirus, antioksidan, antikanker, antitumor, antikolesterol, dan antiulcer. Penggunaan lidah buaya dalam produk farmasi juga telah mengalami perkembangan diantaranya yaitu sediaan nano partikel, tablet, suppositoria, gel dan krim. Kata Kunci— Aloe vera L., Aktivitas farmakologi, Perkembangan produk ABSTRACT Aloe vera L. contains many natural chemical compounds, such as anthraquinone, amino acids, acemannan, aloesin, glucomannan which are responsible for providing therapeutic effects that are useful in pharmaceutical. The aims of this review is to provide information about pharmacological activities and products development of Aloe vera. In this article review, online and offline literatures were used. Online literature such us journals and articles obtained from local and international, while the offline literature such us books and e-books. It is known that aloe vera has a variety of pharmacological activities, that act as antiinflammatory, wound healing, antibacterial, antifungal, antiviral, antioxidant, anticancer, antitumor, anticholesterol, and antiulcer. Pharmaceutical products of Aloe vera also have been developed such us nanoparticles products, tablets, suppositories, gels and creams. Keywords— Aloe vera L., Pharmacological activities, Products development
Aktivitas Tabir Surya Sediaan Krim dan Lotion Ekstrak Etanol Kulit Buah Nanas (Ananas comosus L.Merr)
Authors: Zulfa Elya , Fatchurrohman M. 
Published: April 2019

ABSTRAK Kulit buah nanas mengandung flavonoid dan terbukti memiliki aktivitas tabir surya. Penelitian ini bertujuan untuk mengetahui aktivitas tabir surya krim dan lotion ekstrak etanol kulit buah nanas (EEKBN) dengan menilai SPF sediaan. Krim dan lotion dibuat dalam 3 formula berdasarkan variasi konsentrasi ekstrak FI (15,0 %), FII (17,5 %), FIII (20,0 %), kontrol basis, dan kontrol positif digunakan sediaan tabir surya yang ada dipasaran. Krim yang diperoleh dilakukan pengujian aktivitas tabir surya dengan melihat nilai SPF. Data yang diperoleh dianalisis menggunakan ANOVA taraf kepercayaan 95%. Hasil penelitian menunjukkan bahwa Nilai SPF ketiga formula krim berturut-turut 20,97, 24,32 dan 25,75, sedangkan pada sediaan lotion berturut-turut memiliki nilai SPF sebesar 9,796, 11,589 16,268. Jika dibandingkan dengan kontrol (+) ketiga formula krim dan lotion memiliki nilai SPF yang tidak setara (Sig<0,05). Kata Kunci: krim, lotion, kulit buah nanas, flavonoid, SPF ABSTRACT Pineapple skin contains flavonoids and is proven to have sunscreen activity. This study aims to determine the activity of cream sunscreen and pineapple peel (EEKBN) ethanol extract lotion by assessing the preparation of SPF. Creams and lotions were made in 3 formulas based on variations in FI extract concentrations (15.0%), FII (17.5%), FIII (20.0%), base control, and positive control used in the market. The cream obtained was tested for sunscreen activity by looking at the SPF value. The data obtained were analyzed using ANOVA 95% confidence level. The results showed that the SPF values of the three cream formulas were 20.97, 24.32 and 25.75 respectively, while in the lotion preparations respectively had an SPF value of 9,796, 11,589 16,268. When compared to the control (+) the three cream and lotion formulas had unequal SPF values (Sig <0.05). Keywords: cream, lotion, pineapple skin, flavonoid, SPF
Uji Aktivitas Antioksidan Ekstrak Etanol Kulit Buah Mundar (Garcinia forbesii King.) Menggunakan Metode DPPH (2,2-Diphenyl-1-Picrylhydrazil)
Authors: Muthia Rahmi , Saputri Revita , Verawati Sulastri Azistina 
Published: April 2019

ABSTRAK Kulit buah Mundar (G. forbesii King.) merupakan tanaman endemik yang berasal dari Kalimantan Selatan yang berpotensi memiliki aktivitas antioksidan. Penelitian ini dilakukan untuk menguji aktivitas antioksidan ekstrak etanol 30% dan 70% kulit buah Mundar (G. forbesii King.) yang diperoleh dengan metode ekstraksi sokhletasi. Pengujian aktivitas antioksidan dilakukan dengan metode DPPH (2,2-Diphenyl-1-Picrylhydrazil) secara kualititatif dan kuantitatif dengan kuersetin sebagai kontrol positif. Hasil uji aktivitas antioksidan ekstrak etanol 30% dan 70% kulit buah Mundar (G. forbesii King.) secara kualitatif menunjukkan adanya aktivitas antioksidan yang ditandai dengan noda kuning pada plat kromatografi lapis tipis (KLT) setelah disemprot dengan larutan DPPH 0,1mM. Hasil uji aktivitas antioksidan secara kuantitatif menghasilkan nilai IC50 (Inhibitory Concentration) secara berturut-turut dari ekstrak etanol 30% kulit buah Mundar (G. forbesii King.); ekstrak etanol 70% kulit buah Mundar (G. forbesii King.); dan kuersetin adalah 717,01 ppm; 534,69 ppm; dan 2,04 ppm. Ekstrak etanol 70% kulit buah Mundar (G. forbesii King.) memiliki aktivitas antioksidan yang lebih baik dibandingkan ekstrak etanol 30% kulit buah Mundar (G. forbesii King.). Kata kunci: Kulit buah Mundar (G. forbesii King.), antioksidan, DPPH, kromatografi lapis tipis (KLT), IC50 ABSTRACT Antioxidants are compounds that can counteract free radicals. Mundar rind (Garcinia forbesii King.) is endemic plants from South Kalimantan that has the potential antioxidant activity. This research was conducted antioxidant activity test of ethanolic extract 30% and 70% of Mundar rind (G. forbesii King.) obtained by soxhlet extraction method. Antioxidant activity test of Mundar rind (G. forbesii King.) used the DPPH (2,2-Diphenyl-1-Picrylhydrazil) method qualitatively and quantitatively with quercetin as a positive control. The results of the antioxidant activity test qualitatively of ethanolic extract 30% and 70% of Mundar rind (G. forbesii King.) showed antioxidant activity marked with a yellow spot with purple background on kromatogram after sprayed with DPPH solution 0,1mM. The results of the antioxidant activity test quantitatively obtained IC50(Inhibitory Concentration) value respectively of ethanolic extract 30%; ethanolic extract 70%; and quercetin were 717,01 ppm; 534,69 ppm; and 2,04 ppm. The ethanolic extract 70% of Mundar rind (G. forbesii King.) had better antioxidant activity than the ethanolic extract 30% of Mundar rind (G. forbesii King.) Keywords: Mundar rind (G. Forbesii King.), antioxidant, DPPH, thin layer chromatography (TLC), IC50
Pengembangan Formula Solid Lipid Nanoparticles (SLN) Hidrokortison Asetat
Authors: Jafar Garnadi , Agustin Eriska , Puryani Deny 
Published: April 2019

ABSTRAK Dermatitis Atopik (DA) adalah penyakit inflamasi kulit kronis dan kambuhan, terutama pada anak-anak. Pengobatan DA salah satunya menggunakan hidrokortison. Sifat lipofil dari hidrokortison asetat (HA) akan berpengaruh terhadap penetrasinya kedalam kulit jika diberikan secara topikal. SLN (Solid Lipid Nanoparticle) merupakan sistem penghantaran obat baru yang terdiri dari matriks lipid padat dan surfaktan yang terdispersi dalam air dengan ukuran partikel 10-1000nm untuk meningkatkan solubility, stability, dan loading capacity. Metode: SLN dibuat dengan homogenisasi panas menggunakan magnetic stirrer selama 10 menit suhu 600C, dilanjutkan dengan ultraturax 5000rpm selama 10 menit dan ultrasonikasi dengan sonikator probe dengan amplitudo 55% selama 15 menit, mode pulse on-off 10 detik. Optimasi basis SLN dilakukan pada beberapa jenis lipid (GMS Cutina dan Apifil) dan surfaktan (Pluracare, Tegocare, Plantacare, dan Cremofor RH 40). Basis SLN yang terpilih adalah GMS Cutina sebagai lipid padat dengan kosentrasi 4%,5%, dan 6% dan surfaktan Pluracare 3% berdasarkan ukuran partikel terkecil, FTIR, dan DSC yang menunjukkan kompatibilitas dengan HA. Hasil: Formula SLN hidrokortison asetat yang digunakan adalah lipid padat GMS Cutina 4%-6% dan surfaktan Pluracare 3% menghasilkan ukuran partikel 806nm ± 124,67nm - 958nm ± 91,28nm, nilai PI masing-masing 0,874±0,07 - 0,943±0,15, dan nilai efisiensi penjerapan (EE) 12,5%, - 83,3%. Kata Kunci : Hidrokortison Asetat, Homogenisasi Panas, SLN (Solid Lipid Nanoparticle), Ultrasonikasi ABSTRACT Atopic dermatitis (DA) is a recurrent chronic inflammatory skin disease. Treatment of DA used one of them is hydrocortisone acetate. The lipophilic properties of hydrocortisone acetate (HA) will affect its penetration into the skin when administered topically. SLN (Solid Lipid Nanoparticle) is a new drug delivery system consisting of a solid lipid matrix and a water dispersed surfactant with a particle size of 10-1000nm to improve solubility, stability, and loading capacity. Method: SLN used hot homogenization using magnetic stirrer for 10 minutes temperature 600C, followed by ultraturax 5000rpm for 10 minutes and ultrasound with probe sonicator with 55% amplitude for 15 minutes, 10 second pulse on-off mode. Optimization of the SLN base was performed on several types of lipids (GMS Cutina and Apifil) and surfactants (Pluracare, Tegocare, Plantacare, and Cremofor RH 40). The preferred SLN base is GMS Cutina as a solid lipid with a concentration of 4%, 5%, and 6% and a 3% Pluracare as a surfactant based on the smallest particle size, FTIR, and DSC showing compatibility with HA. Result: The formula of SLN hydrocortisone acetate used GMS Cutina 4% -6% as a solid lipid and Pluracare 3% as a surfactant resulted a particle size of 806nm ± 124.67nm - 958nm ± 91.28nm, PI value of 0.874 ± 0.07 - 0.943 ± 0.15 , and the efficiency entrapment (EE) 12.5%, - 83.3%. Keywords : Hydrocortisone Acetate, Hot Homogenization, SLN (Solid Lipid Nanoparticle), Ultrasound
Strategies to Avoid Osteonecrosis in Unstable Slipped Capital Femoral Epiphysis
Authors: Daley Erika , Zaltz Ira 
Published: April 2019

» Osteonecrosis of the femoral epiphysis following slipped capital femoral epiphysis (SCFE) causes substantial patient morbidity.» The etiology of osteonecrosis following SCFE is multifactorial, and multiple treatment strategies, including techniques of epiphyseal reduction, capsulotomy, and timing of surgical intervention, that are intended to reduce this risk have been utilized.» At the present time, because of conflicting data and the lack of high-level evidence, there are a paucity of data to determine the role that these techniques play in reducing the risk of osteonecrosis.» Further scientific research is needed to understand the etiology of osteonecrosis following SCFE.
Methods for Estimating Fracture Abundance and Size From Borehole Observations
Authors: Berg Charles R. 
Published: April 2019

SummaryThis study develops deterministic, exact equations relating fracture frequency (P10), density (P32), and length and width dimensions of rectangular and elliptical fractures from borehole observations. These general equations are applicable to both image logs and cores. A Monte Carlo type of simulation model generated the stochastic data used to derive the equations. The equations use five basic parameters relating frequency to density: borehole diameter, fracture length, fracture width, fracture angle with borehole axis (β), and the rotation angle of the long fracture axis within the fracture plane (γ). For both general equations, density corrections can be applied to individual fractures to find density. Fracture porosity is calculated on a per–fracture basis by applying aperture to density corrections. Both equations match the model to within the small standard deviation between simulations. In addition, the elliptical equation generally agrees with the existing exact theory.The study also develops methods for calculating fracture height (width) and length for rectangular fractures. Fracture height and length are calculated by observing the borehole–enclosed height and length and comparing them with the borehole–enclosed area. The calculation of fracture size is extended to estimate block height and length (block–face size.)These relationships cover a wide range of fracture size and orientation vs. borehole diameter. The theory is valid from small boreholes to tunnels. The general equations consider fractures as planar objects with length and width dimensions and negligible aperture compared with the other dimensions. Fracture aperture is applied, on a per–fracture basis, after the density correction to calculate fracture porosity. In addition to density and porosity calculations, an existing method for fracture–frequency prediction is improved by applying the general relationships.The methods described here are demonstrated using an image log from a vertical well from British Columbia, Canada. In this well, an image log was run over the Triassic section, including the zone of interest, the Montney Formation. Although the average fracture size in the Montney was very large, possibly on the order of tens of meters, they had a much smaller block–face size, on the order of a few meters, which could explain some of the production aspects from this formation.
Analysis of CNS-Associated Lymphatics
Authors: Herz Jasmin , Louveau Antoine , Mesquita Sandro Da , Kipnis Jonathan 
Published: April 2019

Abstract
The study of meningeal lymphatic vessels of the central nervous system (CNS) has recently gathered momentum, with several papers dissecting their role in draining solutes from cerebrospinal fluid and brain (Louveau et al., Nature 523(7560):337–341, 2015; Antila et al., J Exp Med 214(12):3645–3667, 2017; Aspelund et al., J Exp Med 212(7):991–999, 2015). Methodological capabilities, however, have been limited to few laboratories due to difficulties reproducibly visualizing these rare cell subsets in the meninges. To explore meningeal lymphatics fundamental role during homeostasis and how they may contribute to human pathology, the field has begun to require purification and characterization of lymphatic endothelial cells. Here, modern cell biological techniques involving a combination of histological, flow-cytometric, and functional drainage assays are applied to brain and spinal cord meninges and detailed stepwise procedures used for successful in vivo and ex vivo characterization of meningeal lymphatic vessels.
Prevalence of hepatitis C infection among general population and high-risk groups in the EU/EEA: A systematic review update
Authors: Han Ru , Zhou Junwen , François Clément , MondherToumi  
Published: April 2019

Abstract
Background

Although significant improvement in efficacy measured by sustained virological response, the high acquisition costs of direct-acting antivirals limit the access for patients and influence the costs of health care resource utilization in hepatitis C. It is important to have the latest estimates of prevalence, especially in the high risk groups, for cost of illness, cost-effectiveness and budget impact studies.

Methods

Original studies on the estimates of the prevalence among general and high-risk populations in the European Union/European Economic Area (EU/EEA) were retrieved from Medline and Embase for the period from 2015 to 2018. All included studies were evaluated for risk of selection bias and summarized together in narrative form. Results from previous reviews and the updated searches were compared per country among different populations, respectively.

Results

Among 3871 studies identified, 46 studies were included, with 20 studies used for the estimate for the general population, 3 for men who have sex with men (MSM), 6 for prisoners and 17 for people who inject drugs (PWID). Compared with the results reported in previous systematic reviews, the updated estimates were lower than previous ones in most available countries. Anti-HCV general population prevalence estimates ranges from 0.54% to 1.50% by country. The highest prevalence of anti-HCV was found among PWID (range of 7.90% - 82.00%) followed by prisoners (7.00% - 41.00%), HIV-positive MSM (1.80% - 7.10%), HIV-negative HIV status-MSM (0.20% - 1.80%), pregnant women (0.10% - 1.32%) and blood donors (0.03% - 0.09%).

Conclusions

Our study highlights the heterogeneity in anti-HCV prevalence across different population groups in EU/EEA. The prevalence also varies widely between European countries. There are many countries that are not represented in our results, highlighting the need for the development of robust epidemiological studies.
A genomic resource for the sedentary semi-endoparasitic reniform nematode, Rotylenchulus reniformis Linford & Oliveira
Authors: Showmaker Kurt C. , Sanders William S. , Eves-van den Akker Sebastian , Martin Brigitte E. , Platt Roy N. , Stokes John V. , Hsu Chuan-Yu , Bartlett Benjamin D. , Peterson Daniel G. , Wubben Martin J. 
Published: April 2019

Abstract
The reniform nematode (Rotylenchulus reniformis) is a sedentary semi-endoparasitic species that is pathogenic on many row crops, fruits, and vegetables. Here, the authors present a draft genome assembly of R. reniformis using small- and large-insert libraries sequenced on the Illumina GAIIx and MiSeq platforms.