bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early sinusoidal heart rate patterns and heart rate variability to assess hypoxia–ischaemia in near‐term fetal sheep
Authors: Kasai Michi , Lear Christopher A. , Davidson Joanne O. , Beacom Michael J. , Drury Paul P. , Maeda Yoshiki , Miyagi Etsuko , Ikeda Tomoaki , Bennet Laura , Gunn Alistair J. 
Published: September 2019

Key points
Therapeutic hypothermia needs to be started as early as possible in the first 6 h after acute injury caused by hypoxia–ischaemia (HI), but the severity and timing of HI are often unclear. In this study we evaluated whether measures of heart rate variability (HRV) might provide early biomarkers of HI.
The duration but not magnitude of suppression of HRV power and conversely increased sample entropy of the heart rate were associated with severity of HI, such that changes in the first 3 h did not discriminate between groups.
Relative changes in HRV power bands showed different patterns between groups and therefore may have the potential to evaluate the severity of HI.
Aberrant fetal heart rate patterns and increased arginine vasopressin levels in the first hour after moderate and severe HI were correlated with loss of EEG power after 3 days’ recovery, suggesting potential utility as early biomarkers of outcome.
AbstractTherapeutic hypothermia is partially neuroprotective after acute injury caused by hypoxia–ischaemia (HI), likely because the timing and severity of HI are often unclear, making timely recruitment for treatment challenging. We evaluated the utility of changes in heart rate variability (HRV) after HI as biomarkers of the timing and severity of acute HI. Chronically instrumented fetal sheep at 0.85 gestational age were exposed to different durations of umbilical cord occlusion to produce mild (n = 6), moderate (n = 8) or severe HI (n = 8) or to sham occlusion (n = 5). Heart rate (HR) and HRV indices were assessed until 72 h after HI. All HI groups showed suppressed very low frequency HRV power and elevated sample entropy for the first 3 h; more prolonged changes were associated with greater severity of HI. Analysis of relative changes in spectral power showed that the moderate and severe groups showed a shift towards higher HRV frequencies, which was most marked after severe HI. This shift was associated with abnormal rhythmic HR patterns including sinusoidal patterns in the first hour after HI, and with elevated plasma levels of arginine vasopressin, which were correlated with subsequent loss of EEG power by day 3. In conclusion, absolute changes in HRV power in the first 3 h after acute HI were not significantly related to the severity of HI. The intriguing relative shift in spectral power towards higher frequencies likely reflects greater autonomic dysfunction after severe HI. However, sinusoidal HR patterns and elevated vasopressin levels may have utility as biomarkers of severe HI.
Visualization of Droplet Nucleation on Patterned Hybrid Surfaces
Authors: Hoque Muhammad Jahidul , Keum Hohyun , Kim Seok , Miljkovic Nenad 
Published: September 2019

Abstract
Hydrophobic-hydrophilic hybrid surfaces have the potential to enhance and optimize condensation heat transfer. The optimum design of hybrid surfaces has been shown to greatly improve heat transfer performance when compared to that of pure hydrophobic or hydrophilic surfaces. However, challenges remain related to the manufacture of hybrid patterns on large area samples. Here, we develop and visualize a simple stamping method to pattern surfaces for well-defined hydrophobic and hydrophilic regions. The reversible control of adhesion of patterned Polydimethylsiloxane (PDMS) stamps was utilized to form arrays of hydrophilic regions on HTMS (Heptadecafluoro-(tetrahydrodecyl) Trimethoxysilane). To visualize the nucleation behavior, we utilized optical microscopy. Water condensation on the hybrid surfaces resulted in nucleation of droplets that initiated on the hydrophilic patterns. The visualizations shown here not only demonstrate the spatial control of heterogeneous nucleation of water, but present design guidelines for the development of scalable hybrid surfaces for the study of controlled droplet nucleation phenomena and to enable the control of droplet distribution and density during dropwise condensation.
Formation and evolution of a subduction-related mélange: The example of the Rocca Canavese Thrust Sheets (Western Alps)
Authors: Roda Manuel , Zucali Michele , Regorda Alessandro , Spalla Maria Iole 
Published: September 2019

Abstract
In the Sesia-Lanzo Zone, Western Alps, the Rocca Canavese Thrust Sheets (RCT) subunit is characterized by a mixture of mantle- and crust-derived lithologies, such as metapelites, metagranitoids, metabasics, and serpentinized mantle slices with sizes ranging from meters to hundreds of meters. Structural and metamorphic history suggests that the RCT rocks experienced a complex evolution. In particular, two different peak conditions were obtained for the metabasics, representing different tectono-metamorphic units (TMUs), namely, D1a under eclogite facies conditions and D1b under lawsonite-blueschist-facies conditions. The two TMUs were coupled during the syn-D2 exhumation stage under epidote-blueschist-facies conditions. The different rocks and metamorphic evolutions and the abundance of serpentinites in the tectonic mixture suggest a possible subduction-related mélange origin for the RCT. To verify whether a subduction-related mélange can record tectono-metamorphic histories similar to that inferred for the RCT, we compare the pressure-temperature evolutions with the results of a 2-D numerical model of ocean-continent subduction with mantle wedge serpentinization. The predictions of the numerical model fully reproduce the two peak conditions (D1a and D1b) and the successive exhumation history of the two TMUs within the subduction wedge. The degree of mixing estimated from field data is consistent with that predicted by the numerical simulation. Finally, the present-day location of the RCT, which marks the boundary between the orogenic wedge (Penninic and Austroalpine domains) and the southern hinterland (Southalpine domain) of the Alpine chain, is reproduced by the model at the end of the exhumation in the subduction wedge. Therefore, the comparison between natural data and the model results confirms the interpretation of the RCT as a subduction-related mélange that occurred during exhumation within a serpentinized mantle wedge.
Petrogenesis of Late Triassic high-Mg diorites and associated granitoids with implications for Paleo-Tethys evolution in the northeast Tibetan Plateau
Authors: Tan Jun , Wei Jun-Hao , Zhao Shao-Qing , Li Yan-Jun , Liu Yan , Liu Xiao-Yang , Zhang Fei , Gan Jin-Rong , Wang Zhi-Hua 
Published: September 2019

Abstract
Recent research on Paleo-Tethys tectonics has identified a huge late Paleozoic to Mesozoic igneous belt that extends more than 2500 km in the northeast Tibetan Plateau. However, the magma genesis and evolution in this belt remains a subject of considerable debate. This paper presents a combination of zircon U-Pb ages, mineral compositions, major and trace element concentrations, and Sr-Nd-Hf isotopic data for the plutons across the Zhiduo arc belt that marks the site connecting different tectonic-magmatic units. The studied rocks from one quartz diorite, two granodiorite plutons, and their mafic enclaves define a continuous compositional evolution varying from high- to medium-K calc-alkaline gabbroic diorite to granodiorite. Laser ablation–inductively coupled plasma–mass spectroscopy U-Pb analyses of zircons from these three plutonic suites and one mafic enclave yield Late Triassic ages of 222–217 Ma, establishing that the mafic and felsic magmas were nearly coeval. All these rocks are featured by zoned hornblende and plagioclase with Mg- and Ca-rich mantles or oscillatory change in compositions. They exhibit high and variable MgO (up to 4.88–5.66 wt%), Cr, and Ni contents except that one granitoid pluton (Dangjiangrong) possesses high Co (up to 145.0 ppm). They are characterized by subduction-type trace element patterns, with prominent positive Rb, Th, Pb, and K anomalies and negative Ba, Nb, P, and Ti. Together with continuous and heterogeneous Sr-, Nd-, and zircon Hf-isotopic compositions, it suggests that these Late Triassic high-Mg diorites and associated granitoids were generated through magma mixing and fractional crystallization accompanied by chemical exchange. Taking into account the magmatic record from nearby regions, we suggest that double-sided subduction and rollback of the subducting Paleo-Tethys oceanic slab is the main mechanism to generate geochemically-varied magmatism in the northeast Tibetan Plateau, and eventually close the Paleo-Tethys Ocean during much of the Late Triassic.
Association between carotid intima-media thickness and bone mineral density: a cross-sectional study in Vietnamese men and women aged 50 years and older
Authors: Nguyen Lich T , Pham Vinh N , Chau Phuong M N , Ho-Pham Lan T , Nguyen Tuan V 
Published: September 2019

ObjectivesThe association between osteoporosis and atherosclerosis remains controversial. We sought to define the relationship between carotid intima-media thickness and bone mineral density (BMD) in individuals of Vietnamese background.Design and settingCross-sectional study in Ho Chi Minh City, Vietnam.ParticipantsThe study involved 1460 individuals (559 men) aged 50 years and older (average age 59 years) who were randomly recruited from the community.Outcome measuresBMD at the femoral neck and lumbar spine was measured by dual-energy X-ray absorptiometry (Hologic, Waltham, Massachusetts, USA). Carotid intima-media thickness (cIMT) was measured using a Philips Ultrasonography (HD7XE). The presence of atherosclerotic plaque was ascertained for each individual. The association between cIMT and BMD was analysed by a multiple linear regression model.ResultsIn unadjusted analysis, cIMT was positively associated with femoral neck BMD in men (p=0.005), but not in women (p=0.242). After adjusting for age, smoking, diabetes and hypertension, the association remained statistically significant in men (partial R2=0.005; p=0.015) but not in women (partial R2=0.008; p=0.369). When the analysis was limited to individuals aged 60 years and older, the association between cIMT and BMD was no longer statistically significant. There was no statistically significant association between cIMT and lumbar spine BMD in either men or women.ConclusionsIn Vietnamese individuals aged 50 years and older, there is a clinically non-significant but statistically significant association between carotid intima-media thickness and BMD in men, not in women.
Preparing Chinese patients with comorbid heart disease and diabetes for home management: a mixed methods study
Authors: Liu Xian-Liang , Willis Karen , Wu Chiung-Jung (Jo) , Fulbrook Paul , Shi Yan , Johnson Maree 
Published: September 2019

ObjectiveTo explore how health education received by patients with acute coronary syndrome (ACS) and type 2 diabetes mellitus (T2DM) influences patients’ self-efficacy and self-management and changes in behaviour at, and following, hospital discharge.DesignThis study used a convergent mixed methods design.ParticipantsTwenty-one participants with completed surveys and interviews at discharge and home follow-up were included in the analysis.SettingAt a coronary care unit of a major hospital in Shanghai, China.ResultsMost participants (n=17) did not perceive they had sufficient education or ability to manage both conditions. More concerning was that most participants (n=16) reported low self-efficacy in the management of ACS symptoms. Three major themes were identified: self-management of ACS and T2DM represents a complex interplay between individual self-efficacy, knowledge and skills, as individuals navigate shifting self-management priorities due to perceived condition severity; the social environment is integral to lifestyle and behaviour change and managing multiple health conditions requires body and mind systems’ harmony.ConclusionsThe inpatient education received did not enhance participants’ confidence to manage either condition on discharge. While an unhealthy lifestyle was embedded within social roles and norms, some social activities, such as square dancing, positively influenced health behaviour. Culturally appropriate education for Chinese people with diabetes and ACS should contain information on maintaining mind and body harmony. Family members should be involved in formal education.
Effectiveness of a behavioural intervention involving regular weighing and feedback by community midwives within routine antenatal care to prevent excessive gestational weight gain: POPS2 randomised controlled trial
Authors: Daley Amanda , Jolly Kate , Jebb Susan A , Roalfe Andrea , Mackilllop Lucy , Lewis Amanda , Clifford Sue , Usman Muhammad , Ohadike Corah , Kenyon Sara , MacArthur Christine , Aveyard Paul 
Published: September 2019

ObjectivesTo assess the effectiveness of a brief behavioural intervention based on routine antenatal weighing to prevent excessive gestational weight gain (defined by US Institute of Medicine).DesignRandomised controlled trial.SettingAntenatal clinic in England.ParticipantsWomen between 10+0and 14+6weeks gestation, not requiring specialist obstetric care.InterventionsParticipants were randomised to usual antenatal care or usual care (UC) plus the intervention. The intervention involved community midwives weighing women at antenatal appointments, setting maximum weight gain limits between appointments and providing brief feedback. Women were encouraged to monitor and record their own weight weekly to assess their progress against the maximum limits set by their midwife. The comparator was usual maternity care.Primary and secondary outcome measuresExcessive gestational weight gain, depression, anxiety and physical activity.ResultsSix hundred and fifty-six women from four maternity centres were recruited: 329 women were randomised to the intervention group and 327 to UC. We found no evidence that the intervention decreased excessive gestational weight gain. At 38 weeks gestation, the proportions gaining excessive gestational weight were 27.6% (81/305) versus 28.9% (90/311) (adjusted OR 0.84, 95% CI: 0.53 to 1.33) in the intervention and UC group, respectively. There were no significant difference between the groups in anxiety or depression scores (anxiety: adjusted mean −0.58, 95% CI:−1.25 to –0.8; depression: adjusted mean −0.60, 95% CI:−1.24 to –0.05). There were no significant differences in physical activity scores between the groups.ConclusionsA behavioural intervention delivered by community midwives involving routine weighing throughout pregnancy, setting maximum weight gain targets and encouraging women to weigh themselves each week to check progress did not prevent excessive gestational weight gain. There was no evidence of psychological harm.Trial registration numberISRCTN67427351
Interventions across the retirement transition for improving well-being: a scoping review protocol
Authors: Rodríguez-Monforte Miriam , Fernández-Jané Carles , Martin-Arribas Anna , Sitjà-Rabert Mercè , Canet Vélez Olga , Sanromà-Ortiz Montserrat , Vilaró Jordi , Carrillo-Alvarez Elena 
Published: September 2019

IntroductionThe work-to-retirement transition involves a process of psychologically and behaviourally distancing oneself from the workforce that is often accompanied by other social changes. The person is confronted with new social roles, expectations, challenges and opportunities that can influence lifestyle and well-being. In the scientific literature, we find recent reports of interventions aimed at improving health and well-being in people at retirement age. However, there is still a gap of knowledge on how different interventions during retirement might improve health status. We intend to conduct a scoping review with the aim of describing interventions for improving well-being across the retirement transition.Methods and analysisThe methodological framework described by Arksey and O’Malley; the Joanna Briggs Institute guidelines as well as the Preferred Reporting Items for scoping reviews and Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols statements will be followed. Eligibility criteria comprise of: (a) all type of original studies, review articles or reports published on journals as well as grey literature; (b) describing interventions to improve the well-being in adults across their retirement transition; (c) including participants before, during and after retirement; (d) all publications must describe variables associated with participants’ physical and/or psychological and/or social well-being and/or perceived quality of life related to these; (e) no language restriction and (f) published from January 2000 to March 2019. The main findings will be summarised using a narrative descriptive synthesis approach and grouped following the population, concept and context principles. A stakeholder meeting will be held to provide feedback on the findings and to develop next steps in research and practice.Ethics and disseminationApproval from a research ethics committee is not required, as no personal information will be collected. We plan to disseminate our research findings at different levels: scientific community, clinical and social arenas, as well as to healthcare leaders and policymakers and general population. The project has been registered at Open Science Framework with the name TRANSITS: work to retirement transition project.
Development of a self-guided web-based exercise intervention (SPIN) to treat shoulder pain in people living with spinal cord injury: protocol of a mixed methods study
Authors: Stavric Verna , Saywell Nicola , Kayes Nicola Maree 
Published: September 2019

IntroductionChronic shoulder pain is common after spinal cord injury (SCI) and limits community mobility. This leads to loss of independence and reduced quality of life. Evidence suggests that exercises can help reduce shoulder pain. However, cost, expertise and transport barriers frequently limit access to treatment services. The objective of this study is to develop an evidence-based, acceptable, usable and persuasive self-guided web-based exercise intervention to treat shoulder pain in people living with SCI.Methods and analysisAn iterative and phased person-based approach (PBA) will capture users’ perspectives on usability and acceptability to develop guiding principles that will shape the design of the intervention. The intervention will be based on key elements identified through participant input and from evidence identified through systematic and narrative reviews, to ensure the intervention addresses participants’ needs and increase the likelihood of uptake. The prototype will be iteratively refined through focus groups and think-aloud sessions. Review data will be synthesised drawing on systematic and narrative review conventions. Qualitative data will be analysed using conventional content analysis (planning phase) and directed content analysis (development phase) to inform intervention design and refinement.Ethics and disseminationEthical approval has been granted by the Auckland University of Technology Ethics Committee (AUTEC) in Auckland, New Zealand. The results of the study will be published in a peer-reviewed journal and presented at relevant national and international conferences. A summary of findings will be presented to key stakeholder groups. We will progress to a definitive trial should the findings from this intervention development study indicate the intervention is acceptable and usable.
Effectiveness in clinical practice versus efficacy of dipeptidyl peptidase-4 inhibitors in clinical trials for type 2 diabetes: protocol for systematic review
Authors: Batel-Marques Francisco , Pereira Diogo , Mendes Diogo , Alves Carlos , Penedones Ana 
Published: September 2019

IntroductionData supporting the use of oral antidiabetic drugs mainly rely on data from premarketing clinical trials. Real-world data studies are crucial to evaluate effectiveness of drugs. The aim of this systematic review is to compare the results obtained for efficacy and effectiveness endpoints on clinical trials and those obtained from routine clinical practice of dipeptidyl peptidase-4 inhibitors.Methods and analysisThis systematic review will include randomised controlled trials and observational studies evaluating the efficacy and effectiveness of dipeptidyl peptidase-4 inhibitors, respectively. A literature search will be performed at Medline, Embase, Cochrane Controlled Register of Trials and ClinicalTrials.gov. Search terms comprised the drug name (including the pharmacotherapeutic class and the international non-proprietary name). Data on haemoglobin A1C, blood glucose and body weight will be retrieved. The risk of bias will be independently assessed according to the checklist proposed by Downs and Black. Data will be analysed using descriptive statistics and meta-analysis when applicable.Ethics and disseminationEthical approval is not required as no primary data are collected. This systematic review will be disseminated through a peer-reviewed publication and at conference meetings.
End-of-life care in cancer and dementia: a nationwide population-based study of palliative care policy changes
Authors: Kuo Lou-Ching , Lee Jung Jae , Cheung Denise Shuk Ting , Chen Ping-Jen , Lin Chia-Chin 
Published: September 2019

ObjectivesThe National Health Insurance programme started providing coverage for inpatient care in palliative care (PC) units of acute care hospitals in 2000; however, initially, only PC provided to patients with terminal cancer was covered. A PC policy that enabled PC reimbursement for patients with dementia was implemented in 2009. However, the association of this PC policy with end-of-life care remains unclear. The study aims to compare the association of the PC policy with end-of-life care between patients with dementia and patients with cancer during the last 6 months of their lives.MethodsWe analysed the claims data of 7396 patients dying with dementia (PDD) and 24 319 patients dying with cancer (PDC) during 1997–2013.ResultsAmong PDC, while the percentage of receiving PC increased from 3.6% in 1999 to 14.2% by the end of 2000 (adjusted OR (aOR)=4.07, 95% CI 2.70 to 6.13) and from 20.9% in 2010 to 41.0% in 2013 (aOR=1.40, 95% CI 1.33 to 1.47), vasopressor use decreased from 71.6% in 1999 to 35.5% in 2001 (aOR=0.90, 95% CI 0.82 to 0.98). Among PDD, PC use increased from 0.2% in 2009 to 4.9% in 2013 (aOR=2.05, 95% CI 1.60 to 2.63) and cardiopulmonary resuscitation use decreased from 17.6% in 2009 to 10.0% in 2013 (aOR=0.83, 95% CI 0.76 to 0.90).ConclusionsImplementation of the PC policy in Taiwan was associated with improved PC utilisation among patients with cancer and dementia, which may reduce unnecessary medical care procedures.