bluuebunny/crossref_metadata_2025_split huggingface dataset:
Creating Consensus Educational Goals for Pediatric Sepsis via Multicenter Modified Delphi
Authors: Woods Jason M. , Scott Halden F. , Zaveri Pavan P. 
Published: August 2018

AbstractClinical care of pediatric sepsis depends on early recognition and basic initial steps and thus focused educational materials for providers in these early phases of care are needed. The authors sought to identify educational goals and establish a framework for those materials.The authors conducted a Delphi process to create consensus educational goals for the recognition and treatment of pediatric sepsis, focused on the needs of emergency and acute care providers. Experts in pediatric sepsis quality improvement and education were recruited. In each round the experts determined if a particular goal was appropriate for inclusion and provided edits if required. Free‐text responses and additional goals were accepted. The primary author deidentified and collated the responses and distributed an updated list of goals prior to each round.Five experts participated in the Delphi process. After three rounds the panelists unanimously agreed on 14 educational goals. These goals include three on recognition, five on early treatment, three on treatment response, and three on continued treatment.Using a Delphi process the authors established a list of educational goals for pediatric sepsis care. The experts largely agreed upon the initial set of goals and quickly came to consensus on the majority of topics. This highlights a foundation for any future educational interventions. In addition to creating content standards for pediatric sepsis education, this Delphi process represents a useful tool that may be adaptable to educational content development in other topics.
Preparedness for rapid veno‐venous extracorporeal membrane oxygenation introduction for pediatric severe acute respiratory distress syndrome: a case report
Authors: Toida Chiaki , Muguruma Takashi , Hashiba Katsutaka , Gakumazawa Masayasu , Morimura Naoto 
Published: August 2018

CasePrevious research has suggested that venovenous extracorporeal membrane oxygenation (vvECMO) is useful for patients refractory to conventional therapy. We report a pediatric case of influenza A(H1N1)pdm09 infection with a good outcome following rapid initiation of vvECMO.This patient was a 13‐year‐old boy with severe acute respiratory distress syndrome due to influenza virus. Severe acute respiratory distress syndrome according to the Berlin definition, Murray score of 3.3, and severe air leak syndrome were found.OutcomePuncture for the cannula began 67 min after admission, and vvECMO management was rapidly initiated within 90 min after admission. Introduction of vvECMO required 23 min to complete. The patient was weaned from vvECMO on day 5 and he was discharged home without any complication.ConclusionIt is essential to prepare a system that enables the rapid introduction of vvECMO for children in the emergency center.
Rhodium‐Catalyzed [4+2+1] Cycloaddition of In Situ Generated Ene/Yne‐Ene‐Allenes and CO
Authors: Tian Zi‐You , Cui Qi , Liu Cheng‐Hang , Yu Zhi‐Xiang 
Published: August 2018

AbstractReported herein is the first rhodium‐catalyzed [4+2+1] cycloaddition of in situ generated ene/yne‐ene‐allenes and CO to synthesize challenging seven‐membered carbocycles fused with five‐membered rings. This reaction is designed based on the 1,3‐acyloxy migration of ene/yne‐ene‐propargyl esters to ene/yne‐ene‐allenes, followed by oxidative cyclization, CO insertion, and reductive elimination to form the final [4+2+1] cycloadducts. The possible competing [4+1], [4+2], and [2+2+1] cycloadditions were disfavored, making the present reaction an efficient way to access functionalized 5/7 rings.
Alkalilithosilikate: Renaissance einer reputablen Substanzklasse mit überraschenden Lumineszenzeigenschaften
Authors: Dutzler Daniel , Seibald Markus , Baumann Dominik , Huppertz Hubert 
Published: August 2018

AbstractWir berichten hier über einen bisher unbekannten synthetischen Zugang zur Substanzklasse der Alkalilithosilikate, welche erstmals durch Hoppe in den 1980er Jahren beschrieben wurden. Mit der Synthese und Charakterisierung von NaK7[Li3SiO4]8 waren wir des Weiteren in der Lage, die Familie der Alkalilithosilikate um ein zusätzliches Mitglied zu erweitern. Erstaunlicherweise zeigen NaK7[Li3SiO4]8 sowie die bereits etablierten Alkalilithosilikate Na[Li3SiO4] und K[Li3SiO4] bei Dotierung mit Eu2+ unvorhergesehene Lumineszenzeigenschaften. Na[Li3SiO4]:Eu2+ zeigt eine ultraschmalbandige, blaue und K[Li3SiO4]:Eu2+ eine Breitbandemission, während NaK7[Li3SiO4]8:Eu2+ eine gelb‐grüne Emission mit zwei Banden bei Anregung durch nahes UV‐ bis Blaulicht aufweist. Folglich handelt es sich bei allen untersuchten Substanzen dieser Verbindungsklasse um höchst interessante Leuchtstoffe für zukünftige Anwendungen in phosphorkonvertierenden LEDs.
Pack die Sonne in den Tank: Zur Weiterentwicklung nachhaltiger Energiesysteme
Authors: Schlögl Robert 
Published: August 2018

AbstractDer Umbau von Energiesystemen hin zu nachhaltigen Lösungen schreitet seit einigen Jahren voran. Damit kann seine Wirkung im Klimaschutz durch Projektionen abgeschätzt werden. Dies geschieht hier für die Region der Europäischen Union. Das Resultat wird mit den Zielen des Pariser Klimavertrages verglichen. Es zeigt sich, dass zusätzliche qualitativ andersartige Maßnahmen ergriffen werden müssen.
Regioselective Metal‐ and Reagent‐Free Arylation of Benzothiophenes by Dehydrogenative Electrosynthesis
Authors: Lips Sebastian , Schollmeyer Dieter , Franke Robert , Waldvogel Siegfried R. 
Published: August 2018

AbstractA novel strategy for the synthesis of biaryls consisting of a benzothiophene and a phenol moiety is reported. These heterobiaryls are of utmost interest for pharmaceutical, biological, and high‐performance optoelectronic applications. The metal‐ and reagent‐free, electrosynthetic, and highly efficient method enables the generation of 2‐ and 3‐(hydroxyphenyl)benzo[b]thiophenes in a regioselective fashion. The described one‐step synthesis is easy to conduct, scalable, and inherently safe. The products are afforded in high yields of up to 88 % and with exquisite selectivity. The reaction also features a broad scope and tolerates a large variety of functional groups.
Acrylonitrile‐butadiene‐styrene/nitrile butadiene rubber blends enhanced by anhydrous cobalt chloride
Authors: Shao Chengli , Shang Peng , Mao Yapeng , Li Qiuying , Wu Chifei 
Published: August 2018

ABSTRACTAcrylonitrile‐butadiene‐styrene (ABS)/nitrile butadiene rubber (NBR) blends in the composition of 90/10 filled with anhydrous cobalt chloride (CoCl2) particles are successfully prepared to investigate the impact of CoCl2 on the composites properties. The coordination reaction between CoCl2 particles and nitrile groups in both ABS and NBR phase is generated by heat pressing at 190 °C for 15 min. Fourier transform infrared and X‐ray photoelectron spectroscopy are used for the investigation of the coordination reaction. Scanning electron microscopy and transmission electron microscopy are utilized to study microstructure of the composites. It is found that the solid‐state coordination reaction takes place between nitrile groups (‐CN) and cobalt ions (Co2+), which leads to increases in mechanical properties and glass transition temperature (Tg). The tensile strength and impact strength of ABS/NBR/CoCl2 composites are improved by about 14% and 29%, respectively, in contrast to that of pure ABS, with the CoCl2 loading in the range of 5–7 wt %. The studies of scanning electron microscopy and transmission electron microscopy demonstrate that the discrete NBR components are dispersed uniformly in ABS phase and the CoCl2 particles tend to disperse in NBR phase, which promotes the toughness of the composites. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46747.
Cellulose fatty acid ester coated papers for stand‐up pouch applications
Authors: Willberg‐Keyriläinen Pia , Ropponen Jarmo , Alakomi Hanna‐Leena , Vartiainen Jari 
Published: August 2018

ABSTRACTStand‐up pouches are one of the fastest growing packaging concepts, which are replacing the traditional packaging formats. In this study, stand‐up pouch prototypes are prepared from cellulose fatty acid coated heat‐sealed virgin kraft paper with leak proof seals. This study demonstrates that molar mass controlled cellulose ester (C6‐C16) coatings can significantly improve the barrier properties of virgin kraft paper. All cellulose ester coatings performed better compared to that of PLA. Cellulose ester coatings also improved the resistance of virgin kraft paper against tested nonpolar oil and grease compounds. In addition, the cellulose ester coatings had no antimicrobial activity, and fewer microbes adhered to them than to the PLA surface. The results demonstrate that cellulose fatty acid ester coatings have high potential in future applications requiring good barrier properties. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46936.
Self‐assembled biogenic melanin modulated surface chemistry of biopolymers‐colloidal silica composite porous matrix for the recovery of uranium
Authors: Tripathi A. , Melo J. S. 
Published: August 2018

ABSTRACTA new composite porous matrix surface modulated by self‐assembled melanin was developed and investigated for its affinity to bind uranium from an aqueous medium. The composite matrix was synthesized using biopolymers (i.e., agarose and alginate) and inorganic colloidal silica nanoparticles (AACS) by the process of cryotropic‐gelation at subzero‐temperature. Post‐synthesis surface modification of AACS matrix with melanin (MAACS) was performed by green chemistry. The in situ sequestrial conversion of l‐Dopa by the biocatalytic activity of tyrosinase enzyme allows the formation of melanin on the surface of AACS matrix. The functional moieties on the matrix display fast kinetics and high binding capacity with respect to uranium. MAACS matrix showed high porosity (~90%) with interconnected pores, high swelling kinetics and permeability. Other physicochemical properties of the matrix, such as thermal stability, storage modulus, and surface charge potential were found to be increased, while percent degradation decreased, which demonstrate improved properties of the matrix after impregnation of silica nanoparticles and surface functionalization with melanin. Thermodynamic parameters suggest that the binding of uranyl ions is passive and spontaneous. The concentrated recovery of uranium was achieved with reusability potential of adsorbent. These results suggest an environment friendly and safer method for the recovery of uranium. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 46937.
Imine‐N‐Heterocyclic Carbenes as Versatile Ligands in Ruthenium(II) p‐Cymene Anticancer Complexes: A Structure–Activity Relationship Study
Authors: Yang Yuliang , Guo Lihua , Tian Zhenzhen , Liu Xicheng , Gong Yuteng , Zheng Hongmei , Ge Xingxing , Liu Zhe 
Published: August 2018

AbstractA family of novel imine‐N‐heterocyclic carbene ruthenium(II) complexes of the general formula [(η6‐p‐cymene)Ru(C^N)Cl]PF6− (where C^N is an imine‐N‐heterocyclic carbene chelating ligand with varying substituents) have been prepared and characterized. In this imine‐N‐heterocyclic carbene chelating ligand framework, there are three potential sites that can be modified, which distinguishes this class of ligand and provides a body of flexibilities and opportunities to tune the cytotoxicity of these ruthenium(II) complexes. The influence of substituent effects of three tunable domains on the anticancer activity and catalytic ability in converting coenzyme NADH to NAD+ is investigated. This family of complexes displays an exceedingly distinct anticancer activity against A549 cancer cells, despite their close structural similarity. Complex 9 shows the highest anticancer activity in this series against A549 cancer cells (IC50=14.36 μm), with an approximately 1.5‐fold better activity than the clinical platinum drug cisplatin (IC50=21.30 μm) in A549 cancer cells. Mechanistic studies reveal that complex 9 mediates cell death mainly through cell stress, including cell cycle arrest, inducing apoptosis, increasing intracellular reactive oxygen species (ROS) levels, and depolarization of the mitochondrial membrane potential (MMP). Furthermore, lysosomal damage is also detected by confocal microscopy.
Analysis and control of spatial limit sets and spatial chaos appearance in mimo cascade connected nonlinear systems
Authors: Zlatkovic Bojana M. , Samardzic Biljana 
Published: August 2018

AbstractThe oscillatory and chaotic dynamics of MIMO cascade connected nonlinear systems are analyzed in this paper. For that purpose the known theorems of limit sets existence in appropriate nonlinear discrete systems are used. Control of spatial limit sets and spatial chaos appearance in MIMO cascade connected nonlinear systems using modified Pyragas method is also analyzed. The results are illustrated by examples and confirmed with simulations.
Drinking water disinfection byproducts and risk of orofacial clefts in the National Birth Defects Prevention Study
Authors: Weyer Peter , Rhoads Anthony , Suhl Jonathan , Luben Thomas J. , Conway Kristin M. , Langlois Peter H. , Shen Dereck , Liang Dong , Puzhankara Soman , Anderka Marlene , Bell Erin , Feldkamp Marcia L. , Hoyt Adrienne T. , Mosley Bridget , Reefhuis Jennita , Romitti Paul A. ,   The National Birth Defects Prevention Study
Published: August 2018

AbstractBackgroundMaternal exposure to drinking water disinfection byproducts (DBP)s may contribute to orofacial cleft (OFC) development, but studies are sparse and beset with limitations.MethodsPopulation‐based, maternal interview reports of drinking water filtration and consumption for 680 OFC cases (535 isolated) and 1826 controls were linked with DBP concentration data using maternal residential addresses and public water system monitoring data. Maternal individual‐level exposures to trihalomethanes (THM)s and haloacetic acids (HAA)s (µg/L of water consumed) were estimated from reported consumption at home, work, and school. Compared to no exposure, associations with multisource maternal exposure <1/2 or ≥1/2 the Maximum Contaminant Levels (MCL)s for total THMs (TTHM)s and HAAs (HAA5) or Maximum Contaminant Level Goals (MCLG)s for individual THMs and HAAs (if non‐zero) were estimated for all OFCs and isolated OFCs, cleft palate (CP), and cleft lip ± cleft palate (CL/P) using logistic regression analyses.ResultsCompared to controls, associations were near or below unity for maternal TTHM, HAA5, and individual THM exposures with all OFCs and isolated OFCs, CP, and CL/P. Associations also were near or below unity for individual HAAs with statistically significant, inverse associations observed with each OFC outcome group except CL/P.ConclusionsThis study examined associations for maternal reports of drinking water filtration and consumption and maternal DBP exposure from drinking water with OFCs in offspring. Associations observed were near or below unity and mostly nonsignificant. Continued, improved research using maternal individual‐level exposure data will be useful in better characterizing these associations.
Rapid identification of antimicrometastases drugs using integrated model systems with two dimensional monolayer, three dimensional spheroids, and zebrafish xenotransplantation tumors
Authors: Fu Afu , Peh Yu Ming , Ngan Weida , Wei Na , Luo Kathy Qian 
Published: August 2018

AbstractTreating systemic metastases at the micrometastatic stage is a potential strategy to inhibit cancer metastasis. This study aims to establish an apoptosis sensor‐based platform for rapid, effective, and noninvasive identification of drugs that can inhibit the proliferation of micrometastatic cancer cells. We stably transfected the plasmid DNA encoding the fluorescence resonance energy transfer‐based caspase‐3 sensor into highly metastatic melanoma B16F10 cells. The resulting B16F10‐C3 cells were applied for screening of antiproliferative and proapoptotic drugs in two‐dimensional (2D) monolayer, three‐dimensional (3D) spheroids, and zebrafish xenotransplantation tumors. All studies were conducted in 96‐well plates in a high throughput manner. Fourteen compounds including six chemotherapeutic drugs and eight kinase inhibitors were tested. Thirteen compounds failed the tests due to: Drug resistance, low efficacy, poor pharmacokinetic profile, and/or high side effects to zebrafish. The only compound that passed all tests was pan‐phosphatidylinositol 3‐kinase (PI3K) inhibitor LY294002, which inhibited the proliferation of B16F10‐C3 cells in both 2D and 3D cultures. More important, it significantly reduced the xenograft tumor size in zebrafish by decreasing the viability of metastatic cancer cells. Our study suggests that the PI3K/AKT pathway is a potential therapeutic target for the reactivation of tumor dormancy and proliferation of micrometastases. Moreover, this integrated approach is effective for rapid identification of systemic antimetastases drugs.
Reconstruction of tricarboxylic acid cycle in Corynebacterium glutamicum with a genome‐scale metabolic network model for trans‐4‐hydroxyproline production
Authors: Zhang Yu , Zhang Yun , Shang Xiuling , Wang Bo , Hu Qitiao , Liu Shuwen , Wen Tingyi 
Published: August 2018

Abstracttrans‐4‐Hydroxy‐
l‐proline (Hyp) is an abundant component of mammalian collagen and functions as a chiral synthon for the syntheses of anti‐inflammatory drugs in the pharmaceutical industry. Proline 4‐hydroxylase (P4H) can catalyze the conversion of
l‐proline to Hyp; however, it is still challenging for the fermentative production of Hyp from glucose using P4H due to the low yield and productivity. Here, we report the metabolic engineering of
Corynebacterium glutamicum for the fermentative production of Hyp by reconstructing tricarboxylic acid (TCA) cycle together with heterologously expressing the
p4h gene from
Dactylosporangium sp. strain RH1. In silico model‐based simulation showed that α‐ketoglutarate was redirected from the TCA cycle toward Hyp synthetic pathway driven by P4H when the carbon flux from succinyl‐CoA to succinate descended to zero. The interruption of the TCA cycle by the deletion of
sucCD‐encoding the succinyl‐CoA synthetase (SUCOAS) led to a 60% increase in Hyp production and had no obvious impact on the growth rate. Fine‐tuning of plasmid‐borne ProB* and P4H abundances led to a significant increase in the yield of Hyp on glucose. The final engineered Hyp‐7 strain produced up to 21.72 g/L Hyp with a yield of 0.27 mol/mol (Hyp/glucose) and a volumetric productivity of 0.36 g·L
−1·hr
−1 in the shake flask fermentation. To our knowledge, this is the highest yield and productivity achieved by microbial fermentation in a glucose‐minimal medium for Hyp production. This strategy provides new insights into engineering
C. glutamicum by flux coupling for the fermentative production of Hyp and related products.
Positive predictive values of fecal immunochemical tests used in the STOP CRC pragmatic trial
Authors: Nielson Carrie M. , Petrik Amanda F. , Jacob Lorie , Vollmer William M. , Keast Erin M. , Schneider Jennifer L. , Rivelli Jennifer S. , Kapka Tanya J. , Meenan Richard T. , Mummadi Rajasekhara R. , Green Beverly B. , Coronado Gloria D. 
Published: August 2018

AbstractAnnual fecal immunochemical testing (FIT) is cost‐effective for colorectal cancer (CRC) screening. However, FIT positivity rates and positive predictive value (PPV) can vary substantially, with false‐positive (FP) results adding to colonoscopy burden without improving cancer detection. Our objective was to describe FIT PPV and the factors associated with FP results among patients undergoing CRC screening. In an ongoing pragmatic clinical trial of mailed‐FIT outreach, clinics delivered one of three FIT brands (InSure, OC‐Micro, and Hemosure). Patients who had a positive FIT result and a follow‐up colonoscopy were included in this analysis (N = 1130). Patients’ demographic and medical histories were abstracted from electronic health records (EHR). Associations with a FP result (ie, a positive FIT result with no evidence of advanced neoplasia during follow‐up colonoscopy) were evaluated for FIT brand and patient factors using mixed‐effects multivariable logistic regression. The mean proportion of FIT‐positive results ranged from 8% in centers using the OC‐Micro test to 21% for Hemosure. PPVs for advanced neoplasia were 0.30 to 0.17, respectively (P for χ2 = 0.08). In multivariable‐adjusted models, use of Hemosure was associated with greater odds of a FP result than OC‐Micro (OR = 2.00, 95% CI: 0.47‐8.56) or InSure (OR = 1.72, 95% CI: 0.44‐6.68). However, only female sex (OR = 1.58, 95% CI: 1.19‐2.10) and history of a colorectal condition (OR = 2.17, 95% CI: 1.13‐4.15) were significantly associated with FP. In conclusion, FIT positivity varied by brand, and FP results differed by patient factors available through the EHR. These results can be used to minimize the frequency of FP results, reducing patient distress and colonoscopy burden.
Dry Reforming of Shale Gas and Carbon Dioxide with Ni‐Ce‐Al2O3 Catalyst: Syngas Production Enhanced over Ni‐CeOx Formation
Authors: Liu Yan , Wu Ye , Akhtamberdinova Zarina , Chen Xiaoping , Jiang Guodong , Liu Dong 
Published: August 2018

AbstractThe dry reforming of shale gas (methane and ethane with an average ratio of 4 : 1) with carbon dioxide (DRS) is considered to be a promising way to produce syngas, which widens the utilization of shale gas and mitigates carbon dioxide emission. In this paper, Ce modified Ni‐based catalysts were developed and the corresponding catalytic performances for DRS were investigated with a fixed bed reactor. Results showed that the catalyst containing 5 wt% of Ni and 5 wt% of Ce performed a best catalytic effect, including the selectivity of syngas and the carbon resistance performance, which is due to the good metal dispersion, strong interaction between Ni and Ce, and the formation of Ni‐CeOx solid solution. The electron transfer between Ni and Ce, substitution of Ni for Ce, and the sequential oxygen vacancies or defects, play significant roles in activating CH4, C2H6 and CO2. The conversion of reactant gas increased with temperature, while the selectivity of syngas is little affected with temperature. In addition, the desired catalyst containing 5 wt% of Ni and 5 wt% of Ce showed good stability in the long‐time operation, which indicates that the Ce modified Ni‐based catalyst is a promising one for the dry reforming of shale gas.
The First C−Cl Activation in Ullmann C−O Coupling by MOFs
Authors: Ramezani Leila , Yahyazadeh Asieh , Sheykhan Mehdi 
Published: August 2018

AbstractIt was found that introduction of only 0.03 mol % Ag(I) into the framework of Cu3(BTC)2 ⋅ xH2O in maghemite anchored CuBTC activated the inert CuBTC astonishingly to exhibit unexpected high catalytic activity for C−Cl activation in coupling of chloroarenes with phenols without the use of expensive ligands. This is the first application of mixed‐metal MOFs in the C−X activation. Putting reusability and activity together, a TON over 15000 was obtained which is the highest TON compared with all its precedents even better than the results by Pd catalysts.