bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytokine release syndrome treated with tocilizumab following ipilimumab–nivolumab combination therapy in advanced renal cell carcinoma
Authors: Inoue Toru , Todaka Akiko , Fuse Masahiro , Suzuki Shuntaro , Sejiyama Shinya , Ando Tadasuke , Shin Toshitaka 
Published: November 2024

IntroductionCytokine release syndrome is a rare but potentially life‐threatening complication of immune checkpoint inhibitor therapy. Its occurrence in renal cell carcinoma treated with combination therapy is less recognized and poses significant management challenges.Case presentationA 50‐year‐old male with metastatic renal cell carcinoma developed severe cytokine release syndrome after receiving ipilimumab–nivolumab combination therapy. The patient presented with high fever, fatigue, and elevated inflammatory markers. Early recognition and prompt intervention with tocilizumab led to rapid clinical improvement.ConclusionThis case highlights the importance of increased awareness, prompt recognition, and targeted management of cytokine release syndrome in renal cell carcinoma patients receiving immune checkpoint inhibitor combination therapy. The rapid response to tocilizumab suggests its potential efficacy in managing immune checkpoint inhibitor‐induced cytokine release syndrome.
Integrated multi‐omics and machine learning reveal a gefitinib resistance signature for prognosis and treatment response in lung adenocarcinoma
Authors: Zhou Dong , Zheng Zhi , Li Yanqi , Zhang Jiao , Lu Xiao , Zheng Hong , Dai Jigang 
Published: November 2024

AbstractGefitinib resistance (GR) presents a significant challenge in treating lung adenocarcinoma (LUAD), highlighting the need for alternative therapies. This study explores the genetic basis of GR to improve prediction, prevention, and treatment strategies. We utilized public databases to obtain GR gene sets, single‐cell data, and transcriptome data, applying univariate and multivariate regression analyses alongside machine learning to identify key genes and develop a predictive signature. The signature's performance was evaluated using survival analysis and time‐dependent ROC curves on internal and external datasets. Enrichment and tumor immune microenvironment analyses were conducted to understand the mechanistic roles of the signature genes in GR. Our analysis identified a robust 22‐gene signature with strong predictive performance across validation datasets. This signature was significantly associated with chromosomal processes, DNA replication, immune cell infiltration, and various immune scores based on enrichment and tumor microenvironment analyses. Importantly, the signature also showed potential in predicting the efficacy of immunotherapy in LUAD patients. Moreover, we identified alternative agents to gefitinib that could offer improved therapeutic outcomes for high‐risk and low‐risk patient groups, thereby guiding treatment strategies for gefitinib‐resistant patients. In conclusion, the 22‐gene signature not only predicts prognosis and immunotherapy efficacy in gefitinib‐resistant LUAD patients but also provides novel insights into non‐immunotherapy treatment options.
In Vitro Osteogenic Response to Copper‐Doped Eggshell‐Derived Hydroxyapatite with Macrophage Supplements
Authors: Patil Tejal V. , Patel Dinesh K. , Lim Ki‐Taek 
Published: November 2024

ABSTRACTThe high bioactivity and biocompatibility of hydroxyapatite (HAP) make it a useful bone graft material for bone tissue engineering. However, the development superior osteoconductive and osteoinductive materials for bone regeneration remains a challenge. To overcome these constraints, Cu‐doped hydroxyapatite (HAP(Cu)) from waste eggshells has been produced for bone tissue engineering. The materials produced were characterized using Fourier transform infrared spectroscopy, x‐ray diffraction, and photoelectron spectroscopy. The scanning microscopy images revealed that the developed HAP was a rod‐like crystalline structure with a typical 80–150 nm diameter. Energy‐dispersive x‐ray spectroscopy showed that the generated HAP was mostly composed of calcium, oxygen, and phosphorus. The Ca/P molar ratios in eggshell‐derived and copper‐doped HAP were 1.61 and 1.67, respectively, similar to the commercially available HAP ratio (1.67). The WST‐8 assay was used to assess the biocompatibility of HAPs with hBMSCs. HAP(Cu) in the media significantly altered the cytotoxicity of biocompatible HAP(Cu). The osteogenic potential of HAP(Cu) was demonstrated by greater mineralization than that of pure HAP or the control. HAP(Cu) showed higher osteogenic gene expression than pure HAP and the control, indicating its stronger osteogenic potential. Furthermore, we assessed the effects of sample‐treated macrophage‐derived conditioned medium (CM) on hBMSCs' osteogenesis. CM‐treated HAP(Cu) demonstrated a significantly higher osteogenic potential vis‐à‐vis pure HAP(Cu). These findings revealed that HAP(Cu) with CM significantly improved osteogenesis in hBMSCs and can be explored as a bone graft in bone tissue engineering.
Treatability of diclofenac and triclosan solutions by catalytic and photocatalytic oxidation processes
Authors: Topkaya Eylem , Arslan Ayla 
Published: November 2024

AbstractBACKGROUNDIn recent years, advanced oxidation processes (AOP) have gained importance as highly effective methods in the treatment of organic substances with toxic and permanent properties. Diclofenac (DCF) and Triclosan (TCS) pollutants, which are from the endocrine disrupting chemicals (EDCs) that were encountered in various aquatic environments such as inlet and outlet waters of treatment plants, surface waters, drinking water, groundwater and sediments were reported in the literature. In this study, mineralisation of DCF and TCS pollutants, which were the EDCs, were investigated by AOPs. The applied processes were O3, O3/UV, O3/ZnO, UV/ZnO, and O3/UV/ZnO. The studies were carried out at two different initial concentrations (5 and 10 mg/L), at 5 ppm ozone dose, 2 × 8 W UVC light, 0.1 g ZnO, in the original pH, and 30 min reaction time.RESULTSThe highest COD and TOC removal efficiencies were determined in O3/UV/ZnO process as 82% COD, 71% TOC at 5 mg/L concentration for DCF pollutant and as 72% COD, 75% TOC at 10 mg/L concentration for TCS pollutant. For these process conditions, the ozone consumptions were determined 0.13 mgO3/mgCODremoved, 0.31 mgO3/mgTOCremoved and 0.69 mgO3/mgCODremoved, 0.98 mgO3/mgTOCremoved, respectively. The electrical energy per order values were found in the range of 12.33–20.88 kWh/m3 for O3/UV/ZnO processes. Treatment costs of these processes were calculated in the range of 0.002 to 44.823 €/m3.CONCLUSIONFor the treatability of DCF and TCS pollutants, ozone‐based advanced oxidation processes, especially O3/UV/ZnO photocatalytic ozone oxidation process were determined as a feasible process. © 2024 Society of Chemical Industry (SCI).
Exploring the journey to genomic testing and genetic services: A qualitative study of parental perspectives of children with rare conditions
Authors: Clark Amy , Wallingford Courtney K. , Krause Molly , Renton Heather , Yanes Tatiane , Jacobs Chris , Brett Gemma , McInerney‐Leo Aideen 
Published: November 2024

AbstractDespite affecting a small portion of the population, rare conditions have a significant impact, collectively affecting around 300 million people worldwide. Historically, early diagnosis has been impeded by failure to recognize rare conditions and order/refer for appropriate genomic testing. The advancements in genome sequencing offer a more agnostic and accelerated approach to the identification and diagnosis of rare disorders, potentially improving health outcomes, reducing the impact of disability, and reducing financial and psychological burdens on families. Due to the complex nature of these conditions, early engagement with genomic testing and clinical genetics services is key to facilitating a diagnosis. This qualitative exploration aimed to understand the journey to genomic testing and services and identify the supports families need during the diagnostic period. We conducted semi‐structured interviews with 24 parents of children with a rare condition. Interviews were analyzed using inductive reflexive thematic analysis. Three themes of the parent experience were identified (1) the need for a streamlined pathway through the healthcare system, (2) the value of healthcare professionals who listen to parents, believed them, and partnered with them, and (3) the power of accurate diagnosis. Our findings indicate that providing direct and timely access to genomic testing for patients with a suspected rare condition could alleviate psychological and financial stressors. Genetic counselors are adept at supporting families affected by rare conditions and are optimally placed to facilitate timely access to genomic testing. Improving timely access may be facilitated through educating primary care physicians and embedding genetic counselors in pediatric settings.
Enteropathy‐associated T‐cell lymphoma: A population‐based cohort study on incidence, treatment, and outcome in the Netherlands
Authors: Meeuwes Frederik O. , Brink Mirian , Plattel Wouter J. , Vermaat Joost S. P. , Kersten Marie José , Wondergem Mariëlle , Visser Otto , van der Poel Marjolein W. M. , Oostvogels Rimke , Woei‐A‐Jin F. J. Sherida H. , Böhmer Lara , Snijders Tjeerd J. F. , Huls Gerwin A. , Nijland Marcel 
Published: November 2024

AbstractIntroductionEnteropathy‐associated T‐cell lymphoma (EATL) is a peripheral T‐cell lymphoma (PTCL) with a poor prognosis. Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with or without etoposide consolidated by autologous stem cell transplantation (ASCT) are recommended for fit PTCL patients. The role of etoposide and ASCT in EATL is unclear.MethodsThis study reports the incidence, treatment, and outcome of EATL patients using the Netherlands Cancer Registry, with nationwide coverage of >95%.ResultsAll patients diagnosed in 1989–2021 (n = 351, 77% treated) were identified (median age 67 years, 56% male, 50% limited stage). Time period analysis assessed trends in primary therapy and overall survival (OS). Treatment included chemotherapy (CT) (34%), surgery (18%), surgery and CT (19%) or CT followed by ASCT (7%). The 5‐year OS for treated patients with limited versus advanced stage was 19% and 9% respectively. The 2‐year OS improved over time (21%–33%, p = 0.06). Surgery only (hazard ratio [HR] 2.16; 95% confidence interval [CI] 1.55–3.01, p < 0.01) and advanced‐stage disease (HR 1.67; 95% CI 1.25–2.23, p = 0.01) were predictors of poor prognosis. ASCT (HR 0.31; 95% CI 0.18–0.56) was associated with improved OS.ConclusionThere was no statistical difference in OS between patients treated with or without etoposide. Current first‐line treatment is ineffective.
高流量持続的血液濾過透析により救命したメトホルミン過量服薬による重度乳酸アシドーシスの1例(A case of severe metformin–associated lactic acidosis treated with high–flow continuous hemodiafiltration)
Authors: 邦生 金尾 , 浩一 上野 , 豊 齋藤 , 聡 鳥海 , 清継 田熊 
Published: November 2024

要旨2型糖尿病と診断されている30歳代の男性。自殺目的にメトホルミンを計70g，ビルダグリプチンを計1g過量服薬し，当院へ救急搬送された。来院時に乳酸5.5mmol/Lと高値であったが，バイタルサインに特記すべき異常はなかった。入院後も乳酸アシドーシスが増悪し乳酸値20mmol/Lまで悪化したため，人工呼吸器管理のうえ高流量持続的血液濾過透析（CHDF）を開始した。乳酸アシドーシス増悪に伴い血圧が低下しショックに陥ったため炭酸ナトリウム静注，ノルアドレナリン，バソプレシン持続静注を開始した。CHDF開始後も乳酸値が測定可能の上限値（30mmol/L）を超えるまで増悪したため，設定をさらに高流量へ変更した。来院翌日の採血では腎機能障害，肝機能障害，凝固能異常があり，多臓器不全の状態であった。その後徐々に乳酸アシドーシスは改善し，第2病日にCHDFを離脱した。血圧も徐々に安定し，第4病日に血管収縮薬投与を終了し，人工呼吸器を離脱した。第8病日に精神科に転科となり，第24病日に独歩退院した。重度のメトホルミン関連乳酸アシドーシスに対しては，間欠的血液透析を第1選択とした血液浄化療法が推奨されるが，高流量CHDFも有効な治療手段になる可能性がある。
Cyclooctyne End‐Functionalized Poly(morpholine‐2,5‐dione)s
Authors: Schreiber Johanna , Göppert Natalie E. , Stafast Leanne M. , Weber Christine , Schubert Ulrich S. 
Published: November 2024

AbstractThe cyclooctyne‐functionalized alcohol (1R,8S,9S)‐bicyclo‐[6.1.0]non‐4‐yn‐9‐ylmethanol (BCN‐OH) is applied as initiator for the organo‐catalyzed ring‐opening polymerization (ROP) of morpholine‐2,5‐diones based on the l‐amino acids valine, isoleucine, and phenylalanine. The ROP is catalyzed by a binary system of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) and 1‐(3,5‐bis(trifluoromethyl)phenyl)‐3‐cyclohexylthiourea (TU) applying a feed ratio of [M]/[I]/[DBU]/[TU] of 100/1/1/10. Kinetic studies reveal that BCN‐OH is capable to initiate the polymerization of morpholine‐2,5‐diones, which proceed in a controlled manner until monomer conversions of 80%. Characterization by means of 1H NMR spectroscopy, size exclusion chromatography (SEC), and matrix‐assisted laser desorption/ionization‐time of flight‐mass spectrometry confirm the covalent attachment of the cyclooctyne moiety as α‐end group of the poly(morpholine‐2,5‐dione)s with maximum dispersities of 1.25. As a proof of concept, a vitamin A end‐functionalized poly(2‐ethyl‐2‐oxazoline) is coupled to a poly(ester amide) by strain‐promoted azide‐alkyne cycloaddition. Characterization of the block copolymer by SEC and DOSY NMR spectroscopy confirm the successful attachment of the two building blocks. The versatile cyclooctyne moiety shall facilitate a metal‐free attachment of other polymer blocks, targeting ligands or dyes at the α‐end group of well‐defined poly(morpholine‐2,5‐dione)s. In consequence, the approach provides access to a new generation of functionalized poly(ester amide)s, which can be customized for specific needs.
Optical Automatic Contour Tracing (O‐ACT) – A novel optical image‐guided contour tracing method for electron beam shaping
Authors: Sohn James J. , Park Jeonghoon , Sen Siddhant , Wu Tianming , Mielke Matt , Kim Siyong 
Published: November 2024

AbstractBackgroundElectron therapy, vital for treating skin lesions and superficial tumors, demands precise electron cutouts to ensure accurate dose delivery. Traditional manual tracing methods introduce uncertainties and inefficiencies, necessitating innovative solutions for custom block creation.PurposeTo introduce and validate the Optical Automatic Contour Tracing (O‐ACT) method, enhancing electron cutout generation's accuracy and efficiency through optical imaging and software automation.MethodsUtilizing a 3D‐printed holder, a centrally‐mounted charge‐coupled device (CCD) camera on the electron applicator secured two distinct perspective images of the skin's contour at varying heights. Through image binarization and skeletonization, we identified the clinical target contour's region‐of‐interests (ROIs) in each setup image. Employing distances from each ROI's center, assessed at 5‐degree intervals from both images, we reconstructed the target contour on the skin. The magnification factor, set at a 95 cm source‐to‐point distance, determined the final cutout shape. We crafted an in‐house software in MATLAB for camera calibration and image processing and juxtaposed our results against the standard clinical cutout from the treatment planning system (TPS) using a correlation coefficient based on masked binary images' mutual information. Additionally, we performed dosimetric evaluations using abstract shapes to compare O‐ACT with other methods.ResultsOur methodology yielded cutout shapes exhibiting remarkable alignment with the TPS clinical cutout. O‐ACT demonstrated superior precision in generating cutout shapes that closely align with the contours in TPS, improving upon other methods in terms of adaptability to patient body shapes and contour accuracy. Dosimetric evaluations showed minimal differences between methods, with O‐ACT providing slightly more consistent results. Dose profile analyses in penumbra regions indicated O‐ACT's improved accuracy compared to conventional methods.ConclusionsPushing the boundaries of traditional practices, our O‐ACT offers a more accurate, efficient, and reproducible method for custom electron cutout creation from clinical setup images. This innovation promises not only to streamline clinical workflow but also to potentially uplift clinical outcomes in radiation oncology by providing more accurate patient‐specific treatment accessary.
A new approach for multislice spatiotemporal encoding MRI in a portable low‐field system
Authors: Qiu Yueqi , Chen Suen , Solomon Eddy , Wang Changyue , Zhong Sijie , Dai Ke , Chen Hao , Frydman Lucio , Zhang Zhiyong 
Published: November 2024

AbstractPurposeSpatiotemporal encoding (SPEN) MRI offers a unique alternative to address image distortion problems in echo planar acquisition‐based techniques, at portable low‐field systems that lack multiple receiver coils. However, existing 2‐π multislice SPEN schemes fail to keep consistent SNRs and contrasts with different numbers of slice settings. This work proposes a new multislice SPEN scheme (SPENms) to achieve stable quality imaging in portable low‐field MRI systems.MethodsThe proposed SPENms includes the insertion of one selective π pulse and one non‐selective π pulse, closely arranged together, before the frequency‐swept π pulse in the original 2D SPEN sequence. Theoretical simulations and experiments on phantoms and human brains were conducted to validate its SNR and contrast performances under different parameters compared to the existing 2‐π multislice SPEN scheme.ResultsBoth simulations and experiments demonstrate the consistent image quality of SPENms with different scanning parameters and targets, as well as good distortion resistance and scan efficiency. Robust diffusion weighted multislice SPEN images of diagnostic value were also highlighted.ConclusionSPENms provides a robust fast echo planar acquisition approach to obtain multislice 2D images with less distortions, consistent SNRs and contrasts at portable low‐field MRI systems.
Multi‐Set MMV Topology Optimization Approach for Sliding Surface Texture Design
Authors: Zhang Weisheng , Tian Honghao , Zhu Bao , Guo Xu , Youn Sung‐Kie 
Published: November 2024

ABSTRACTSurface texture is of great practical importance in applications due to its significant effect on the tribological performance of the sliding surface. In the present work, an explicit topology optimization framework for surface texture design is proposed. For this purpose, the moving morphable void (MMV)‐based explicit topology optimization approach is used to maximize the load carrying capacity (LCC) of the bearing by optimizing the distribution of the surface texture. A multi‐set of voids is established to describe the multi‐film thickness of the texture. By using the explicit geometry information in MMV, the present work can be seamlessly linked to the CAD system, resulting in the accurate processing of complex surface textures. Besides some numerical examples to demonstrate the effectiveness of the proposed approach, experimental tests are also provided to verify the validity of the optimization results.
Characteristics of psychiatric patients with nightmares after suvorexant administration: A retrospective study
Authors: Yasuda Kazuya , Hirano Yoji , Takeda Ryuichiro , Ikeda Ryuji , Ishida Yasushi 
Published: November 2024

AbstractAimSuvorexant is an orexin receptor antagonist (ORA) for the treatment of insomnia. The antagonistic action of suvorexant on orexin receptors is associated with an increase in rapid eye movement (REM) sleep, which can potentially lead to nightmares depending on the patient's condition. However, the precise risk factors for nightmares among patients taking ORAs, such as suvorexant, have yet to be identified. In this retrospective study, we aimed to identify the risk factors for the development of nightmares in patients treated with suvorexant.MethodsThe risk factors were determined by comparing parameters between the nightmare group and the nonnightmare group. This study included 440 patients who received suvorexant at the University of Miyazaki Hospital from April 2014 to January 2021.ResultsWe found that 9.1% (n = 40) of the patients experienced suvorexant‐induced nightmares. There was a significant difference in the median age, which was lower in the nightmare group than in the nonnightmare group (p < 0.01). Furthermore, both multiple logistic regression analysis and Cox proportional hazards regression analysis revealed increased odds ratios for nightmares for individuals aged 20–39 years.ConclusionsThis study revealed that elderly patients taking suvorexant had fewer nightmares than nonelderly patients did.
From Surviving to Thriving: Key Considerations for Weight Control Across Diverse Cancer Survivorship Populations
Authors: Brown Justin C. , Allicock Marlyn , Valle Carmina G. , Agurs‐Collins Tanya 
Published: November 2024

ABSTRACTBackgroundObesity is a chronic, relapsing, progressive disease of excess adiposity that increases the risk of dying from at least 16 types of cancer. The prevalence of obesity has increased more rapidly in cancer survivors compared with the general population. Tailored weight management strategies are needed to improve prognosis and health outcomes in the growing population of cancer survivors. However, certain cancer survivor population subgroups require unique consideration when developing weight management strategies.MethodsIn a symposium convened by The Obesity Society during ObesityWeek 2023 titled “From Surviving to Thriving: Key Considerations for Weight Control Across Diverse Cancer Survivorship Populations,” experts presented the current state of the science and highlighted existing research gaps.ResultsTopics included key considerations for weight management in adolescent and young adult cancer survivors, older adult cancer survivors, and understudied cancer survivor subgroups at high risk for poor health outcomes and innovative interventions that can be tested to improve cancer survivorship.ConclusionsThis report reviews the symposium and offers perspectives from the expert panel about unique opportunities for future research on tailored weight management strategies to equitably improve prognosis and health outcomes in the diverse and growing population of cancer survivors.
A Hybrid Ice Model
Authors: Kahl Saskia , Mehlmann Carolin 
Published: November 2024

ABSTRACTThe continuum viscous–plastic sea‐ice model is widely used in climate models for simulating large‐scale sea‐ice dynamics, usually on grids of several kilometres (10 km). Recently, there is an increasing interest in modelling small‐scale processes that have the potential to impact large‐scale dynamics such as sea‐ice–iceberg interactions. The latter have not yet been studied in the context of climate models as efficient numerical realizations are missing. To close this gap, a hybrid ice‐mélange model has been introduced recently. In the approach, icebergs in form of particles are coupled to the viscous–plastic sea‐ice model by modifying the tensile strength in the presence of icebergs. The icebergs, in the size of several hundreds of metres, are tracked on sub‐grid scale, which makes the approach numerically efficient. In this contribution, we extent the work to a setup that treats both sea‐ice floes and icebergs as particles. We refer to this model framework as the hybrid ice model. We show that the time discretized momentum equation is equivalent to a convex energy minimization problem and therefore allows the use of efficient numerical solvers. Furthermore, we demonstrate that sub‐grid dynamics, such as polynya formation due to grounded icebergs, can be reflected with a full particle representation of the sea‐ice tracers.