bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric congenital buttock sinus tract: 10-year experience in a single institution
Authors: Wang Kai , Peng Chunhui , Pang Wenbo , Wang Dayong , Zhang Tingchong , Wang Zengmeng , Wu Dongyang , Chen Yajun 
Published: July 2019

Abstract
Background: Pediatric congenital buttock sinus tract has rarely been reported, and the manifestations, treatments, and prognosis of such patients remain unknown. The purpose of this study is to review our experience with this disease, and to conclude the clinical characteristics and management of the disease.
Methods: Twenty-two pediatric patients diagnosed with congenital buttock sinus tract were included. Medical records were reviewed, and the patients were followed up. Data were presented using the mean ± standard deviation, median (first quartile, third quartile), frequencies and percentages as appropriate.
Results: Among the 22 patients, there were 8 boys (36.4%) and 14 girls (63.6%). First onset age was 42.00 (12.00, 84.00) months, admission age was 77.77 ± 40.73 months, and overall prior treatment time was 11.00 (6.50, 33.75) months. Twenty-one patients had definite congenital dimples since birth, and later manifested with infection through the dimple. All patients came to the doctor with complaint of the infection. The number of invasive procedures ranged from 0 to 5, with an average of 2. Radiology could exactly display the morphology and show the termination as a retrorectal cyst. The surgical procedure was adopted trans-fistula tract, and the pathological results showed a dermoid cyst in 11 patients and an epidermoid cyst in 10 patients. During the follow-up period of 34.50 (24.25, 87.50) months, 19 patients were uneventful and 3 patients suffered recurrence. Two of them underwent a second operation and had no recurrence ever since. The third patient did not receive a second operation, and the refractory infection was still present.
Conclusions: Pediatric congenital buttock sinus tract is rare and has a female predominance in the morbidity. Patients have a distinctive congenital dimple on the buttock with recurrent infection, and there usually exists a congenital sinus tract from the dimple to the retrorectal space. Total excision is the only method for the cure. The nature of the disease is a retrorectal developing dermoid cyst or epidermoid cyst.
Keywords: Pediatric, Buttock sinus tract, Retrorectal cyst, Treatment, Prognosis
Neonatal Mortality and its Determinates in Public Hospitals of Gamo and Gofa Zones, Southern Ethiopia: Prospective Follow up Study
Authors: Mersha Abera , Bante Agegnehu , Shibiru Shitaye 
Published: July 2019

Abstract
Background

The neonatal period is the most vulnerable time for a child survival. The declines in the neonatal mortality rate have been slower than post-neonatal under-five mortality rate in the majority of countries. This this trend is also similar in Ethiopia, that neonatal mortality was high as compare to post neonatal mortality rate. A large proportion of neonatal deaths occur during the 48 hours after delivery. Different studies was conducted in assessing determinates for neonatal mortality but there is a need to assess the immediate post-partum (within two days following delivery) cause of neonatal mortality that the majority of deaths occurred that time. So, this study is to fill those gaps of aforementioned studies, in assessing the determinate factors affecting neonatal mortality in public hospitals of Gamo and Gofa Zones, Southern Ethiopia.

Methods

A prospective follow up study was conducted among 6,986 study participants from April 5, 2018 to March 5, 2019. Data on causes of neonatal death were collected by using structured verbal autopsy questionnaire. Data were entered in to Epi data version 3.1 and exported to Stata version 15 for analysis. Crude and adjusted estimate β with 95%CI was calculated in the binary logistic regression model. The goodness of fit was tested by log likelihood ratio (LR). In this study P-value < 0.05 was considered to declare a result as statistically significant association.

Results

In this study neonatal mortality incidence ratio was 9.6 (95%CI: 7.5%, 12.2%) per 1000 live births. Age of the mother, number of antenatal care, hemorrhage, sex of the neonate, presentation, gestational age and birth weight were identified as the significant determinates for neonatal mortality cases. Prematurity, infection and birth asphyxia were the most common causes of neonatal mortality cases.

Conclusions

This study indicated that a significant number of neonates were died during neonatal period. Both maternal and neonatal factors were identified. Therefore, early identification of obstetric complications and immediate interventions, strengthening the provision of quality antenatal and postnatal care services are recommended.
Light Enhanced Cognitive Behavioural Therapy (CBT+) for Sleep and Fatigue: Study Protocol for a Randomized Controlled Trial during Chemotherapy for Breast Cancer
Authors: Bean Helena Rose , Stafford Lesley , Little Ruth , Diggens Justine , Ftanou Maria , Alexander Marliese , Francis Prudence A , Bei Bei , Wiley Joshua F 
Published: July 2019

Abstract
Background

Women with breast cancer experience a significantly higher prevalence of sleep disturbances and insomnia compared with the general population. The experience of persistent sleep disturbance places breast cancer patients at a higher risk of psychological and physical morbidity and a reduced quality of life. Treatment of sleep in this population is not standard and is often inadequately managed. This randomised controlled study will examine the effects of both Cognitive Behavioural Therapy for insomnia and sleep (CBT-I) and bright light therapy (BL) on the symptoms of insomnia, fatigue and mental health.

Method/design

Women diagnosed with breast cancer who are or will be receiving intravenous chemotherapy treatment at a major metropolitan cancer centre in Melbourne will be recruited (n=80). Recruitment will occur after diagnosis and prior to completion of chemotherapy. Eligible participants will be randomised to the CBT+ intervention (CBT and BL) or relaxation audio enhanced treatment as usual (TAU+). The intervention group will receive one face-to-face session on sleep strategies, one telephone call, and seven email packages containing CBT-I based information and strategies. Participants will also wear Luminette light glasses for 20 minutes each morning for the six-week duration of the intervention. TAU+ will receive two relaxation audio tracks via email. Outcomes will be measured at multiple points throughout the 6 weeks. Primary outcomes will be symptoms of insomnia and sleep efficiency, measured using the Insomnia Severity Index and a self-reported sleep diary. Secondary outcomes include objective measures of sleep assessed using the ActiGraph wGT3X-BT; and sleep-related complaints, fatigue and mental health, all assessed using the Patient-Reported Outcomes Measurement Information System (PROMIS) measure. Data will also be collected on potential treatment moderators and mechanisms, and adherence to treatment. There will be 3-month follow-up measurements of fatigue, sleep-related impairment, sleep disturbance, depression, and anxiety.

Discussion

This is the first randomised controlled trial to combine CBT and BL for the treatment of sleep disturbances in women with breast cancer. This novel design addresses the multiple causal factors for sleep complaints in this population. Results from this trial will advance knowledge in this field and may have important clinical implications for how best to treat sleep disturbance and insomnia in this population. If effective, the largely email-based format of the intervention would allow for relatively easy dissemination.
The Metabolism of Tanshinone IIA, Protocatechuic Aldehyde, Danshensu, Salvianolic Acid B and Hydroxysafflor Yellow A in Zebrafish
Authors: Wang Ya-Li , Yin Shi-Jun , Yang Feng-Qing , Hu Guang , Zheng Guo-Can , Chen Hua 
Published: July 2019

Background:
Tanshinone IIA (TIIA), protocatechuic aldehyde (PA), danshensu (DSS), salvianolic
acid B (SAB) and hydroxysafflor yellow A (HSYA) are the major components of Salvia miltiorrhiza
Bge. (Danshen) and Carthamus tinctorius L. (Honghua) herbal pair. These active components
may contribute to the potential synergistic effects of the herbal pair.

Objective:
This study aimed to investigate the metabolites of TIIA, PA, DSS, SAB and HSYA in
zebrafish, and to explore the influence of HSYA on the metabolism of TIIA, PA, DSS, and SAB.

Method:
48 h post-fertilization zebrafish embryos were exposed either to each compound alone, TIIA
(0.89 μg/mL), PA (0.41 μg/mL), DSS (0.59 μg/mL), SAB (2.15 μg/mL), and HSYA (1.83 μg/mL) and
in combination with HSAY (1.83 μg/mL). The metabolites of TIIA, PA, DSS, SAB, and HSYA in
zebrafish were characterized using high-performance liquid chromatography/tandem mass spectrometry
(HPLC-MS/MS) and quantitatively determined by HPLC-MS with single and combined exposure.

Results:
Among the 26 metabolites detected and characterized from these five compounds, methylation,
hydroxylation, dehydrogenation, hydrolysis, sulfation and glucuronidation were the main phase I
and phase II metabolic reactions of these compounds, respectively. Furthermore, the results showed
that HSYA could either enhance or reduce the amount of TIIA, PA, DSS, SAB, and their corresponding
metabolites.

Conclusion:
The results provided a reference for the study on drug interactions in vivo. In addition, the
zebrafish model which required much fewer amounts of test samples, compared to regular mammal
models, had higher efficiency in predicting in vivo metabolism of compounds.
Design and Development of Smoking Cessation Apps Based on Smokers’ and Providers’ Perspectives in China: Survey Study
Authors: Xu Junfang , Bricker Jonathan , Fu Xiaoxing , Su Chunyan , Wang Peicheng , Qi Tengfei , Cheng Feng 
Published: July 2019

Background
Although there are more than 60 smartphone apps for smoking cessation in China, many of them do not include the content and features that health care professionals and smokers prefer—which may make them impractical, unengaging, and ineffective. Therefore, we investigated both health care providers’ and smokers’ preferences for features of future smoking cessation apps.

Objective
This study aimed to investigate Chinese health care providers’ and smokers’ desired features of a smoking cessation app, with the goal of providing design recommendations for app designers and researchers.

Methods
Both Chinese smokers who own smartphones (n=357) and Chinese health care providers (n=224) responded to a survey collecting data on their sociodemographic characteristics and opinions on the importance of 20 smoking cessation app design features studied in previous US research.

Results
Chinese health care providers expressed strong support of smoking cessation apps on a number of attitude indicators (range 153/224, 68.3% to 204/224, 91.1%). They rated nearly all (18/20) features as very or extremely important (range 52.2%-83.4%) and rated nearly all features (17/20) as more important than the smokers did. More than 60% of smokers rated the following 4 features as very or extremely important: allow sharing the process of smoking cessation with family members and friends (216/319, 67.7%), helping smokers track their progress (such as the amount of smoking per day; 213/319, 66.8%), helping with the side effects of medications and nicotine withdrawal symptoms (201/319, 63.0%), and adapting to ongoing needs and interests of smokers (194/319, 60.8%). Contrary to a similar study of US smokers and health care providers, Chinese smokers and providers rated reputation and ability to communicate with family members and friends as important features, whereas Chinese smokers rated privacy and security as less important.

Conclusions
The design of future smoking cessation and health behavior change apps should consider perspectives of both providers and smokers as well as the role of culture.
Predicting Energy Expenditure During Gradient Walking With a Foot Monitoring Device: Model-Based Approach
Authors: Kim Soon Ho , Kim Jong Won , Park Jung-Jun , Shin Myung Jun , Choi MooYoung 
Published: July 2019

Background
Many recent commercial devices aim at providing a practical way to measure energy expenditure. However, those devices are limited in accuracy.

Objective
This study aimed to build a model of energy consumption during walking applicable to a range of sloped surfaces, used in conjunction with a simple, wearable device.

Methods
We constructed a model of energy consumption during gradient walking by using arguments based in mechanics. We built a foot monitoring system that used pressure sensors on the foot insoles. We did experiments in which participants walked on a treadmill wearing the foot monitoring system, and indirect calorimetry was used for validation. We found the parameters of the model by fitting to the data.

Results
When walking at 1.5 m/s, we found that the model predicted a calorie consumption rate of 5.54 kcal/min for a woman with average height and weight and 6.89 kcal/min for an average man. With the obtained parameters, the model predicted the data with a root-mean-square deviation of 0.96 kcal/min and median percent error of 12.4%.

Conclusions
Our model was found to be an accurate predictor of energy consumption when walking on a range of slopes. The model uses few variables; thus, it can be used in conjunction with a convenient wearable device.
Using a Mobile Diary App in the Treatment of Borderline Personality Disorder: Mixed Methods Feasibility Study
Authors: Helweg-Joergensen Stig , Schmidt Thomas , Lichtenstein Mia Beck , Pedersen Susanne S 
Published: July 2019

Background
Borderline personality disorder (BPD) is a disorder characterized by difficulties with regulating emotions and impulsive behavior. Long-term monitoring of progress during BPD psychotherapy constitutes a challenge using paper and pencil registration. Hence, a mobile app assessing emotions and progress in treatment may be useful.

Objective
The aim of this study was to examine the feasibility of using the mDiary app as an adjunct to dialectical behavior therapy (DBT) for the treatment of BPD.

Methods
A total of 9 focus group interviews were conducted and analyzed according to the grounded theory approach. Furthermore, the usability of the mDiary app was examined using the System Usability Scale (SUS). The app was implemented in a standard DBT program as an adjunct to DBT. In total, 16 patients (age range 19-41 years) and 23 therapists (age range 25-64 years) from 5 Danish public outpatient psychiatric treatment facilities participated in the study.

Results
Overall, patients were satisfied with the mDiary app, as it was “easy to use” and “always there.” Inside-out innovation, meaning new work tasks generated during implementation and communication of modifications needed in the app, was found to influence the perceived usability negatively among the interviewed therapists. The patients rated the usability as high (mean SUS score 81.2, SD 9.9), whereas therapists rated the mDiary app at an average level (mean 68.3, SD 14.3). Older age of the users correlated with lower usability ratings on the SUS score (Pearson r=−0.60).

Conclusions
The mDiary app was considered as an acceptable and relevant way of registering DBT diary data for both patients and therapists generating increased long-term overview. Older users were overall more reluctant to accept this new technology in clinical practice. Time to align expectations among involved parties needs to be set aside when implementing this new approach to patient monitoring. Here, the focus should be on the realistic use of resources and expected impact on present clinical work.
Variabilities in Childhood Cardiovascular Risk Factors and Incident Diabetes in Adulthood: The Bogalusa Heart Study
Authors: Du Tingting , Fernandez Camilo , Barshop Rupert , Fonseca Vivian , Chen Wei , Bazzano Lydia A. 
Published: July 2019

OBJECTIVE
Although emerging evidence indicates that increased variability in cardiovascular risk factors (CVRFs) among populations at midlife or later is a reliable predictor of adverse health outcomes, it is unknown whether intraindividual CVRF variability during childhood or adolescence is an independent predictor of later-life diabetes. We aimed to examine the association of CVRF variability during childhood with diabetes in later life.

RESEARCH DESIGN AND METHODS
We included 1,718 participants who participated in the Bogalusa Heart Study and had measures at least four times during childhood (aged 4–19 years). The mean follow-up period was 20.5 years. Intraindividual CVRF variabilities during childhood were calculated using SD, coefficient of variation, deviation from age-predicted values, and residual SD based upon four to eight serial measurements in childhood.

RESULTS
Increased variability in BMI or HDL cholesterol (HDL-C) during childhood, irrespective of the indices used, was significantly positively associated with later-life diabetes risk independent of their respective mean levels in childhood and other possible confounding factors. In combined analysis, the magnitude of the association with diabetes risk was similar for high childhood BMI variability and high childhood HDL-C variability. After adjustments for potential confounding variables, other CVRF variabilities including systolic/diastolic blood pressure, total cholesterol, triglycerides, and LDL cholesterol were not significantly associated with diabetes.

CONCLUSIONS
Increased BMI and HDL-C variabilities during childhood were significant risk factors for the development of diabetes independently of diverse risk factors, which may offer new insights into the childhood origin of adult-onset diabetes.
Effects of Light Wavelength on Daughter Cladode Growth and Quality in Edible Cactus Nopalea cochenillifera Cultured in a Plant Factory with Artificial Light
Authors: Horibe Takanori , Imai Shousei , Matsuoka Takuya 
Published: July 2019

Abstract
In this study, we investigated the effects of different-colored light-emitting diodes (LEDs) on the growth and quality of daughter cladodes of the edible cactus Nopalea cochenillifera. Cladodes were cultured hydroponically using the deep-flow technique under red, blue, or a combination of red and blue, or red, blue, and green light in an enclosed-type plant factory. We found that daughter cladodes developed from the mother cladodes in all the treatments, despite pH of the nutrient solution drastically decreasing over time. However, the elongation growth rate of the first daughter cladodes and the number of daughter cladodes produced were highest under red light and lowest under blue light, indicating that blue light suppresses daughter cladode development. The total fresh weight (FW) of the daughter cladodes emerging from a single mother cladode was also lowest under blue light. However, the average FW of the daughter cladodes was the highest under blue light, or under simultaneous irradiation with red and blue light. The number of spines, which is an undesirable characteristic in edible cacti, was significantly lower under red light than under blue light, while the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity of the daughter cladodes was the highest under blue light or under simultaneous irradiation with red and blue light. Our results show that light wavelength has a strong effect on daughter cladode development in N. cochenillifera, so controlling the light environment represents an effective approach for improving the growth and quality of this edible cactus.
The Use of Physical Factors for Seed Quality Improvement of Horticultural Plants
Authors: Krawiec Marcela , Dziwulska-Hunek Agata , Kornarzyński Krzysztof 
Published: July 2019

Abstract
Due to the common trend towards limitation of excessive use of chemicals in agriculture, there is a growth of interest in methods of seed quality improvement that would be safe for the environment. These include methods based on the effect of various physical factors, such as laser light, magnetic field, seed treatment with magnetized water, electric field. The work provides detailed information on the impact of seed stimulation of these factors on germination, growth, development and yielding of horticultural plants. Summarizing the results of the study, it can be concluded that the application of physical factors in appropriate doses can be an effective way to enhance many plant parameters that increase their productivity. The beneficial effects of seed stimulation are mainly related to the first stages of plant life, i.e. – germination, emergence and growth of seedlings. In many cases, the enhancement of these features is also the result of the increase of plant yields. The increase of yield is even several dozen percent. The results of the study encourage the implementation of these physical methods of seed quality improvement into agricultural and horticultural practice.
Molecular Diversity of Two-Spotted Spider Mite (Tetranychus urticae) in Apple Orchards Across Poland and its Potential Link with the Resistance to Meti-Acaricides
Authors: Jęcz Tomasz , Korbin Małgorzata , Gorzka Damian , Mohamed Abdel-Rahman A. , Olszak Remigiusz 
Published: July 2019

Abstract
Two-spotted spider mite (Tetranychus urticae, Koch) possess tremendous ability to develop resistance to pest control chemicals. Hence, although METI-acaricides are quite new group of pesticides, the resistance to this chemicals may shortly become a serious obstacle in two-spotted spider mite management. In presented study, molecular and phenotypic diversity of three laboratory strains and seven T. urticae populations collected from pest-protected apple orchards were analysed in reference to METI-acaricides resistance. The inter-population molecular diversity analysis with a set of RAPD markers revealed 6 populations to be in close relation to susceptible reference strain (GSS). Only one population turned out to be linked relatively close with METI-acaricides resistant strain (Akita). Simultaneously, the results of biological test showed similar relation among the analysed populations, according to the resistance incidence ratio. Obtained results suggest that METI-acaricides resistance trait in two-spotted spider mite is likely to be determined at genomic level and may be considered as an initial stage for developing molecular biology tools for early detection of METI-acaricides resistance in T. urticae populations.
La lectura y la escritura académica en educación superior: el taller como estrategia didáctica
Authors: Asensio Pastor Margarita Isabel 
Published: July 2019

Este artículo recoge una propuesta didáctica de intervención en el aula universitaria centrada en la escritura y la lectura académica, puesto que el Espacio Europeo de Educación Superior (EEES) y la implantación del Plan Bolonia han supuesto un incremento de las horas prácticas y la implantación de un trabajo final de grado para poder graduarse. Por tanto, en este artículo, ofrecemos una propuesta de intervención didáctica basada en el modelo pedagógico de taller por su carácter reflexivo-experimental. En dicho taller nos centramos en las destrezas de comprensión lectora y expresión escrita centradas en los textos científicos académicos: atender a la especificidad de estos textos, el tipo de lenguaje estereotipado y convencional, la estructura de un trabajo académico, la citación, entre otros aspectos. Todas estas características discursivas suponen un desafío para los estudiantes de nuevo ingreso en la educación superior que ha de manejar tanto para realizar sus estudios como para dotarse de las competencias profesionales que requiere sus estudios para su ingreso laboral. En el artículo, además, ofrecemos el análisis de los datos relativos a la intervención didáctica basándonos en un modelo metodológico de investigación-acción.