bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acoustofluidic Tweezers Integrated with Droplet Sensing Enable Multifunctional Closed‐Loop Droplet Manipulation
Authors: Sui Mingyang , Dong Huijuan , Mu Guanyu , Yang Zhen , Ai Ye , Zhao Jie 
Published: November 2024

AbstractDroplet manipulation technologies with surface acoustic waves attract significant attention for applications in fluid handling and bioanalysis. However, existing technologies face challenges in automation, precision, and functional integration, limiting broader applications. In this work, a highly integrated droplet‐sensing acoustofluidic tweezer is developed, incorporating orthogonally arranged slanted finger interdigital transducers and a custom‐designed control and detection circuit system. Using a single acoustic device, this tweezer enables switchable acoustic droplet manipulation and detection, providing multifunctional closed‐loop manipulation of on‐chip microliter‐scale droplets. The platform takes advantage of the wideband frequency response characteristics of the transducers, along with an automated droplet detection algorithm, enabling high‐precision detection of central positions, edge positions, contact diameters, and the number of droplets. With this feedback, automated closed‐loop control of various droplet manipulation functions, including transportation, merging, mixing, splitting, and internal particle enrichment, is achieved for the first time on a single acoustic platform. This significantly enhances the precision, efficiency, and fault tolerance of the manipulation process. This droplet‐sensing acoustofluidic tweezer provides an innovative acoustic solution for droplet manipulation technologies in fields such as fluid processing and biosensing, demonstrating significant application potential.
Fabrication of Long‐Lasting Superhydrophilic Anti‐Fogging Film Via Rapid and Simple UV Process
Authors: Jung Jae Hwan , Kang Yu Bin , Choi Chungryong 
Published: November 2024

AbstractSurface fogging is a common phenomenon that can result in restricted visibility, reduced light absorption, and image distortion. Although both hydrophobic and hydrophilic surfaces are effective in preventing this phenomenon, typical coatings in both have limitations, including low durability and the need for frequent reapplication. To address these issues, a highly durable anti‐fogging film that lasts over five weeks, even under high moisture conditions, while maintaining a promising degree of transparency (> 60%) is developed. A novel statistical random copolymer containing superhydrophilic and photo‐crosslinkable segments that can be simultaneously crosslinked and chemically bonded to various substrates via a simple ultraviolet (UV) irradiation process is synthesized. Notably, the chemical bonding between the anti‐fogging coating and substrate improves not only the durability but also the resistance to external forces and environmental changes. Furthermore, this film is versatile and applicable to diverse substrates, such as car windshields, polymer films, and aluminum foil. The innovative strategy offers a simple, rapid process and durable anti‐fogging performance with broad applications in the automotive industry, optical devices, and building materials.
Real‐Time Wireless Detection of Heavy Metal Ions Using a Self‐Powered Triboelectric Nanosensor Integrated with an Autonomous Thermoelectric Generator‐Powered Robotic System
Authors: Huang Yan‐Tsz , Khan Arshad , Ganguly Anindita , Kaswan Kuldeep , Suresh Sreerag , Cheng Yu‐Ying , Lee Kuan‐Ming , Yu Jui‐Han , Lin Zong‐Hong 
Published: November 2024

AbstractThe integration of the Internet of Things (IoT) with advanced sensing technologies is transforming environmental monitoring and public health protection. In this study, a fully self‐powered and automated chemical sensing system is developed and integrated with a robotic hand for “touch and sense” detection of toxic heavy metal ions (Pb2⁺, Cr⁶⁺, As3⁺) in aquatic environments. The system combines a self‐powered solid‐liquid triboelectric nanosensor (SL‐TENS) with a thermoelectric generator (TEG), which harnesses ambient heat to power the robotic hand, eliminating the need for external power sources. The robotic hand is controlled wirelessly via an exo‐hand, minimizing the risk of exposure during remote monitoring. The sensing component uses copper oxide nanowires (CuO NWs) coated with ion‐selective membranes (ISMs) to enhance triboelectric output and enable highly selective ion detection. The system demonstrates effective real‐time, on‐site detection in lake water and data transmitted wirelessly to the user. This innovative approach provides a highly safe and efficient method for detecting hazardous pollutants in difficult‐to‐access areas, offering significant potential for wireless and real‐time environmental monitoring and hazard prevention, thus contributing to the safeguarding of human health. This study presents a novel advancement in the field of IoT‐enabled environmental monitoring systems.
Embedding Plate‐Like Pyrochlore in Perovskite Phase to Enhance Energy Storage Performance of BNT‐Based Ceramic Capacitors
Authors: Wang Simin , Qian Jin , Ge Guanglong , Zhang Faqiang , Yan Fei , Lin Jinfeng , Tang Luomeng , Yang Menghao , Pan Zhongbin , Wei Xiao , Shen Bo , Liu Zhifu , Zhai Jiwei 
Published: November 2024

AbstractNext‐generation electrical and electronic systems rely on the development of efficient energy‐storage dielectric ceramic capacitors. However, achieving a synergistic enhancement in the polarization and in the breakdown field strength (Eb) presents a considerable challenge. Herein, a heterogeneous combination strategy involving embedding a high Eb plate‐like pyrochlore phase in a high‐polarization perovskite phase is proposed. The embedded plate‐like pyrochlore increases the breakdown field strength and promotes the dynamic polarization response. Meanwhile, the strong spin–orbit coupling effect of the 5d electrons is conducive to the maintenance of the high polarization value of the perovskite. Consequently, the prepared multilayer ceramic capacitor (MLCC) exhibits an ultrahigh Eb and a high polarization. More specifically, an energy storage density (Wrec) of 14.9 J cm−3 with an efficiency of up to 93.4% is achieved for the optimized pyrochlore/perovskite phase. Furthermore, the MLCCs also exhibits an Wrec of ≈ 7.7 J cm−3 ± 4.5% in the temperature range of −50–180 °C. Therefore, this heterogeneous combination strategy therefore provides a simple and effective method for improving the energy‐storage performances of dielectric ceramic capacitors.
Crystallographic Texturing of Electrodeposits for Sustainable Zn Anodes
Authors: Tian Xiaomeng , Sun Ying , Li Hui , Duan Xiaoguang , Zhao Qin , Ma Tianyi 
Published: November 2024

AbstractAqueous Zn metal batteries (AZMBs) offer a promising solution for grid‐scale energy storage. Nonetheless, their commercial deployment is hindered by pivotal challenges related to the Zn metal anode, particularly the morphological heterogeneity of electrodeposits and interfacial chemical instability arising from irreversible and uneven electrodeposition. Crystallographic texturing during Zn electrodeposition emerges as a robust approach to achieve grain‐refinement and chemically stable electrodeposits, thereby promoting the sustainable cycling of the Zn anode. Despite substantial progress in Zn texturing, a comprehensive review that systematically elucidates the principles and mechanisms underlying irregular morphological evolution and crystallographic texturing is still lacking. Therefore, this review addresses this gap by first examining the formation of these issues from a crystallographic perspective. The review then categorizes and details five distinct induction mechanisms for crystallographic texturing in Zn electrodeposits. Eventually, the review offers future perspectives on crystallographic texturing, aiming to advance the transition from academic research to industrial application of AZMBs.
Expanding the Genetic and Phenotypic Spectrum of Mowat‐Wilson Syndrome: A Study of 10 Turkish Patients With an Intrafamilial Recurrence Caused by First Intragenic Large Deletion
Authors: Kablan Ahmet , Aru Esma Ertürkmen , Atar Süleyman , Gumus Aydeniz Aydin , İli Ezgi Gökpınar , Kayhan Gulsum , Tekin Koray , Silan Fatma 
Published: November 2024

ABSTRACTMowat–Wilson syndrome (MWS) is a complex disorder caused by heterozygous ZEB2 gene variations creating haploinsufficiency. The main clinical features are evolving facial dysmorphism, intellectual disability, eye and brain malformations, and various organ anomalies. Our study examines 10 Turkish patients, who had clinical diagnosis, underwent evaluation, clinical investigations, and genetic tests in multiple tertiary centers across Türkiye, and were molecularly diagnosed with MWS. Molecular analysis with sequencing techniques alongside array testing unveiled disease‐causing variations in addition to novel variants, including two siblings with recurrent multiexon deletion. Clinical presentations varied, featuring neurodevelopmental delay and characteristic facial traits and organ malformations across all cases, alongside less frequently reported manifestations such as laryngomalacia or rocker bottom feet in addition to new features such as macroorchidism and osteoporosis. Our findings expand the genetic and phenotypical spectrum of MWS, and hint at potential implications of gonadal mosaicism. While establishing clear genotype–phenotype correlations poses challenges, comprehensive genetic testing remains pivotal for precise diagnosis and management. The study highlights the complexity of MWS genetics, with potential implications of gonadal mosaicism on recurrence. Further research is needed to elucidate mechanisms driving phenotypic variability, potential hotspots, and mechanisms for recurrent variations. We report on the largest cohort with MWS from Türkiye.
Einfluss von Chlorid und Elektrolytstabilität auf die Bildung von Passivierungsschichten an der Negativen Elektrode von Mg Batterien: eine operando EQCM‐D Studie
Authors: Schick Benjamin W. , Vanoppen Viktor , Uhl Matthias , Kruck Matthias , Riedel Sibylle , Zhao‐Karger Zhirong , Berg Erik J. , Hou Xu , Jacob Timo 
Published: November 2024

AbstractWieder aufladbare Magnesium Batterien sind vielversprechend für die zukünftige Energiespeicherung. Ihre praktische Anwendung wird jedoch unter anderem durch niedrige Coulomb'sche Effizienzen bei der Magnesiumabscheidung und ‐auflösung behindert. Grundlegende Prozesse wie die Bildung, Struktur und Stabilität von Passivierungsschichten und der Einfluss verschiedener Elektrolytbestandteile auf diese sind immer noch nicht vollständig verstanden. In dieser Studie erhalten wir einzigartige Einblicke in die ersten Magnesiumabscheidungs‐ und auflösungszyklen, indem wir Magnesium bis(trifluoromethansulfonyl)imid (Mg(TFSI)2)‐ und Magnesium tetrakis(hexafluoroisopropyloxy)borat (Mg[B(hfip)4]2)‐basierte Elektrolyte, jeweils mit und ohne MgCl2, operando auf Goldelektroden mittels hochempfindlicher elektrochemischer Quarzmikrowaage mit Dissipationsmessung (EQCM−D) unter Anwendung hydrodynamischer Spektroskopie vergleichen. Mit den stabilen Mg[B(hfip)4]2‐basierten Elektrolyten ist hocheffizientes und Interphasen‐freies Zyklieren möglich, während die Bildung von Passivierungsschichten Elektrolytverunreinigungen zugerechnet werden kann. Diese bilden sich und degradieren während des sogenannten Konditionierungsprozesses. Mit dem reaktiveren Mg(TFSI)2‐basierten Elektrolyten wachsen während des Zyklierens dicke Passivierungsschichten mit kleinen Poren. Wir zeigen, dass die Zugabe von MgCl2 bei diesen Elektrolyten die Menge an passiviertem Mg verringert und die stromlose Auflösung der Passivierungsschicht beschleunigt. Dies hat einen positiven Effekt, da wir das effizienteste Zyklieren und die gleichmäßigste Abscheidung beobachten, wenn sich keine Interphase auf der Elektrode befindet.
Highly Solvating Electrolytes with Core‐Shell Solvation Structure for Lean‐Electrolyte Lithium‐Sulfur Batteries
Authors: He Mengxue , Zhu Lujun , Liu Yatao , Jia Yongfeng , Hao Yizhou , Ye Guo , Hong Xufeng , Xiao Zhitong , Ma Yue , Chen Jianhao , Shafqat Muhammad Burhan , Pang Quanquan 
Published: November 2024

AbstractThe practical energy density of lithium‐sulfur batteries is limited by the low sulfur utilization at lean electrolyte conditions. The highly solvating electrolytes (HSEs) promise to address the issue at harsh conditions, but the conflicting challenges of long‐term stability of radical‐mediated sulfur redox reactions (SRR) and the poor stability with lithium metal anode (LMA) have dimmed the efforts. We now present a unique core–shell solvation structured HSE formulated with classical ether‐based solvents and phosphoramide co‐solvent. The unique core–shell solvation structure features confinement of the phosphoramide in the first solvation shell, which prohibits severe contact reactions with LMA and endows prolonged stability for [S3]⋅− radical, favoring a rapid radical‐mediated solution‐based SRR. The cell with the proposed electrolyte showing a high capacity of 864 mAh gsulfur−1 under high sulfur loading of 5.5 mgsulfur cm−2 and low E/S ratio of 4 μL mgsulfur−1. The strategy further enables steady cycling of a 2.71‐A h pouch cell with a high specific energy of 307 W h kg−1. Our work highlights the fundamental chemical concept of tuning the solvation structure to simultaneously tame the SRR and LMA stability for metal‐sulfur batteries wherein the electrode reactions are heavily coupled with electrolyte chemistry.
Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease
Authors: Panek Dawid , Pasieka Anna , Jończyk Jakub , Gawlińska Milena , Zaręba Paula , Siwek Agata , Wolak Małgorzata , Mordyl Barbara , Głuch‐Lutwin Monika , Latacz Gniewomir , Brazzolotto Xavier , Chantegreil Fabien , Nachon Florian , Zdarova Karasova Jana , Pejchal Jaroslav , Mzik Martin , Sestak Vit , Prchal Lukas , Odvarkova Jitka , Soukup Ondrej , Korabecny Jan , Sorf Ales , Hamsikova Marie , Zemanova Lucie , Muckova Lubica , Vánova Nela , Dryja Pola , Sałat Kinga , Höfner Georg , Wanner Klaus , Więckowska Anna , Malawska Barbara 
Published: November 2024

AbstractAlzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and behavioral and psychological symptoms of dementia (BPSD). Given that cholinergic neurons are predominantly affected in AD, current treatments primarily aim to enhance cholinergic neurotransmission. However, imbalances in other neurotransmitters, such as γ‐aminobutyric acid (GABA), also contribute to AD symptomatology. In the presented research, using a combination of crystallography and computational methods we developed compound 6 as a dual modulator of GABAergic and cholinergic neurotransmission systems. Compound 6 demonstrated inhibition of BuChE (IC50=0.21 μM) and GABA transporter 1 (IC50=10.96 μM) and 3 (IC50=7.76 μM), along with a favorable drug‐likeness profile. Subsequent in vivo studies revealed the effectiveness of 6 in enhancing memory retention and alleviating anxiety and depression symptoms in animal models, while also proving safe and bioavailable for oral administration. The innovative multi‐target‐directed ligand 6 offers a new approach to treating cognitive deficits and BPSD in AD.
Co‐Feeding CO2 for Methylfuran Aromatization over Bifunctional Zeolite‐Supported ZnMoO4
Authors: Xia Shengpeng , Zhao Kun , Gao Yunfei , Fan Yuyang , Wang Chenyang , Yu Tongpo , Wang Hong , Zhang Jinyang , Wang Zhandong , Zhu Xing , Zhao Zengli , Zheng Anqing 
Published: November 2024

AbstractAromatization of biofuran offers promising approaches for sustainable biochemical production. However, this process is often hampered by low yields and severe coking on traditional zeolite catalysts. Herein, we report co‐feeding CO2 for 2‐methylfuran (MF) aromatization (CCMA) over bifunctional ZSM‐5 supported ZnMoO4. This bifunctional catalyst can achieve both MF and CO2 conversions of >97 %, generating >85 % carbon yield of target arenes and CO with negligible alkenes (0.05 %). Meanwhile, coke formation is remarkably suppressed from 22.3 % to 8.6 %. ZnMoO4/ZSM‐5 is capable of selectively manipulating the reaction intermediates and pathways of the CCMA reactions, favoring the cyclopentenones‐ and alkenes‐based dehydro‐aromatization rather than the benzofurans‐based pathway. This finding challenges the prevailing understanding that MF aromatization follows a hydrocarbon pool mechanism. Moreover, the abundant surface oxygen vacancies of ZnMoO4 facilitate the adsorption of CO2 and its subsequent reaction with coke. These insights into reaction mechanism and catalyst design for co‐conversion of CO2 and biofuran can offer guidelines for process intensification in biomass utilization with a carbon‐negative manner.
Iodine Boosted Fluoro‐Organic Borate Electrolytes Enabling Fluent Ion‐Conductive Solid Electrolyte Interphase for High‐Performance Magnesium Metal Batteries
Authors: Song Xinmei , Sun Jingjie , Ren Wen , Wang Lei , Yang Binze , Ning Hailong , Zhang Pengbo , Caixiang Zhuoma , Tie Zuoxiu , Zhang Xuejin , NuLi Yanna , Jin Zhong 
Published: November 2024

AbstractRechargeable magnesium batteries are regarded as a promising multi‐valent battery system for low‐cost and sustainable energy storage applications. Boron‐based organic magnesium salts with terminal substituent fluorinated anions (Mg[B(ORF)4]2, RF=fluorinated alkyl) have exhibited impressive electrochemical stability and oxidative stability. Nevertheless, their deployment is hindered by the complicated synthesis routes and the surface passivation of Mg metal anode. Herein, we report the design of an advanced electrolyte formulation comprised of tri(hexafluoroisopropyl) borate (B(HFIP)3) and iodine (I2) in 1,2‐dimethoxyethane (DME) solvent, which eventually convert into a Mg[B(HFIP)4]2/DME‐MgI2 electrolyte system upon interacting with Mg anode. The Mg anode reacts with I2 and the electron‐accepting B(HFIP)3, leading to the in situ formation of a solid‐electrolyte interphase layer composed of MgF2 and MgI2 species that can facilitate fast and stable Mg plating/stripping. Compared with the pristine Mg[B(HFIP)4]2/DME electrolyte, the Mg[B(HFIP)4]2/DME‐MgI2 electrolyte exhibited superior electrochemical performance including an ultra‐low overpotential (~80 mV), high Coulombic efficiency and a long‐cycling period over 1500 h. In result, the rechargeable magnesium batteries with Mg[B(HFIP)4]2/DME‐MgI2 electrolyte and Chevrel‐phase Mo6S8 cathode show outstanding compatibility, rapid kinetics, and stable cyclability for over 1200 cycles, surpassing all previously reported boron‐based electrolytes. This work introduces a promising halogen‐enhancement strategy for boron‐based Mg‐ion electrolytes, with the overarching goal of establishing favorable solid‐electrolyte interphases that are pivotal for the advancement and optimization of multi‐valent secondary batteries.
Design of Ligand‐Nonbridging Sites in Metal–Organic Frameworks for Boosting Lithium Storage Capacity
Authors: Sun Lanju , Zhu Chongzhi , Li Lukun , Zheng Rumeng , Yuan Jian , Li Zhiliang , Sun Jikai , Sheng Guan , Wu Hao 
Published: November 2024

AbstractMetal–organic frameworks (MOFs) are lagging in the use of lithium‐ion batteries (LIBs), ascribing to full coordination between metal nodes and organic ligands, to a large extent. By integrating a modulator into a ligand with missing bridging functionality, this study elucidates the role of non‐bridging defect sites in MOFs in tailoring lithium storage performance. A fully bridged pristine MOF (p‐MOF) utilizing the meso‐tetra(4‐carboxylphenyl) porphyrin ligand is compared with a modified MOF containing non‐bridging defects (d‐MOF) introduced by a homologous ligand, tris(4‐carboxyphenyl) porphyrin. Spectroscopic and cryogenic low‐dose electron microscopy techniques verify the presence of non‐bridging defect sites in the d‐MOF and reveal their explicit local structure. Density functional theory calculations show significantly enhanced Li+ adsorption energies and reduced Li+ migration barriers at the non‐bridging sites in the d‐MOF compared to the fully bridging sites in the p‐MOF. As a result, the d‐MOF exhibits exceptional lithium storage performance, achieving a high capacity of 761 mAh g−1 at 0.05 A g−1 and superior rate performance of 203 mAh g−1 at 5 A g−1, which substantially outperform the p‐MOF. This study highlights the potential of modulating MOFs with non‐bridging defects to develop high‐performance LIBs.
Alternating Donor‐Acceptor Ladder‐Type Heteroarene for Efficient Photothermal Conversion via Boosting Non‐Radiative Decay
Authors: Luo Nan , Liu Lingxiu , Luo Jinyang , Zhou Zhaoqiong , Sun Chun‐Lin , Hua Xinqiang , Luo Liang , Wang Jianguo , Geng Hua , Shao Xiangfeng , Zhang Hao‐Li , Liu Zitong 
Published: November 2024

AbstractThe development of novel ladder‐type conjugated molecules is crucial for advancing supramolecular chemistry and material science. In this study, we report a straightforward synthesis of new alternating donor‐acceptor (D‐A) ladder‐type heteroarene, FCDTDPP, and demonstrate its application as photothermal agent for imaging and cancer therapy. FCDTDPP is constructed by vinylene bridge between cyclopentadithiophene (D) and diketopyrrolopyrrole (A) through intramolecular Friedel–Crafts type reaction. FCDTDPP exhibits unique combination of good molecular planarity, efficient intra‐/intermolecular mixed D‐A interactions, and local aromaticity. These features collectively contribute to its broad and intense absorptions with narrow band gap in red band of the spectra, coupled with multiple vibrational absorption feature, thereby enhancing non‐radiative decay process and resulting in efficient photothermal conversion property. FCDTDPP and its nanoparticles (NPs) exhibit superior photothermal conversion performance and stability under 660 nm laser irradiation. Moreover, in vitro studies reveal that FCDTDPP NPs possess excellent biocompatibility, low cytotoxicity, and robust photothermal therapeutic efficacy, a finding further corroborated by preliminary in vivo experiments in tumor‐bearing mice. This work charts a novel course for the molecular engineering of organic photothermal conversion systems, propelling relevant research forward.
Crafting Molecular Tools for 15‐Lipoxygenase‐1 in a Single Step
Authors: Louka Anastasia , Spacho Ntaniela , Korovesis Dimitris , Adamis Konstantinos , Papadopoulos Christos , Kalaitzaki Eirini‐Eleni , Tavernarakis Nektarios , Neochoritis Constantinos G. , Eleftheriadis Nikolaos 
Published: November 2024

AbstractSmall molecule modulators are powerful tools for selectively probing and manipulating proteins in native biological systems. However, the development of versatile modulators that exhibit desired properties is hindered by the lack of a rapid and robust synthetic strategy. Here, we develop a facile and reliable one‐step methodology for the generation of multifunctional toolboxes encompassing a wide variety of chemical modulators with different desired features. These modulators bind irreversibly to the protein target via a selective warhead. Key elements are introduced onto the warhead in a single step using multi‐component reactions. To illustrate the power of this new technology, we synthesized a library of diverse modulators designed to explore a highly challenging and poorly understood protein, human 15‐lipoxygenase‐1. Modulators made include; activity‐based/photoaffinity probes, chemosensors, photocrosslinkers, as well as light‐controlled and high‐affinity inhibitors. The efficacy of our compounds was successfully established through the provision of on demand inhibition and labeling of our target protein in vitro, in cellulo and in vivo; thus, proving that this technology has promising potential for applications in many complex biological systems.