bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mutations in a subfamily of abscisic acid receptor genes promote rice growth and productivity
Authors: Miao Chunbo , Xiao Lihong , Hua Kai , Zou Changsong , Zhao Yang , Bressan Ray A. , Zhu Jian-Kang 
Published: May 2018

Significance
Climate change is challenging plant agriculture and our ability to manage food security. Crop growth and yield are controlled by several phytohormones and their overlapping signal networks. We report here an unexpected aspect of the abscisic acid (ABA) signal network that directly impacts rice productivity. Simultaneously mutating the genes encoding the ABA receptors pyrabactin resistance 1-like 1 (PYL1), PYL4, and PYL6 causes improved growth and increased grain yield in rice. Our work thus reveals an important role of these ABA receptors in growth control and a genetic strategy to improve rice yield.
Spirituality and the Health-Care Professional
Authors: Olsen Cyrus P. 
Published: May 2018

The Church and the clinic, theology and medicine, mutually support one another when the good of the other is justly pursued within an organic context of interdependency. In the midst of rapid change in health care, Catholic health-care workers have much to offer the industry as they bring their spirituality of interdependency into their work environments. Due attention to spiritual nourishment received in the Church via the Eucharist is thus encouraged if Catholic health care is to have the leavening impact it is intended to have in culture. After revisiting Pope John Paul II's social encyclical Laborem exercens (On Human Work, 1981), a spirituality of work is offered for Catholic health-care professionals with particular focus on the Eucharist. Accordingly, this essay presents a theology of the Eucharist that shows how Catholics are bound closely together so that the poverty attending loneliness can be lessened and our mutual efforts at enhancing health may be strengthened. The Church and the clinic, theology and medicine, mutually support one another when the good of the other is justly pursued within an organic context of interdependency bolstered by the Eucharist. Our vocation is unity. Our affliction is to be in a state of duality, and affliction due to an original contamination of pride and of injustice…. Love is thus the right physician for our original illness…. We have lost this unity, we whose religion should be the most incarnate of any. We must recover it. —Simone Weil
Bio-knowledge-based filters improve residue–residue contact prediction accuracy
Authors: Wozniak P P , Pelc J , Skrzypecki M , Vriend G , Kotulska M 
Published: May 2018

Abstract

Motivation
Residue–residue contact prediction through direct coupling analysis has reached impressive accuracy, but yet higher accuracy will be needed to allow for routine modelling of protein structures. One way to improve the prediction accuracy is to filter predicted contacts using knowledge about the particular protein of interest or knowledge about protein structures in general.

Results
We focus on the latter and discuss a set of filters that can be used to remove false positive contact predictions. Each filter depends on one or a few cut-off parameters for which the filter performance was investigated. Combining all filters while using default parameters resulted for a test set of 851 protein domains in the removal of 29% of the predictions of which 92% were indeed false positives.

Availability and implementation
All data and scripts are available at http://comprec-lin.iiar.pwr.edu.pl/FPfilter/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Celebrity endorsed music videos: innovation to foster youth health promotion
Authors: Macnab A J , Mukisa R 
Published: May 2018

Abstract
There are calls for innovation in health promotion and for current issues to be presented in new and exciting ways; in addition to creating engaging messages, novel ways to deliver health messaging are needed, especially where youth are the key target audience. When pupils in WHO Health Promoting Schools were asked what health messages would resonate with them, they also identified celebrities as the ‘messengers’ they would be particularly likely to listen to. Expanding on these discussions, the pupils quoted celebrity-recorded music videos containing health and lifestyle messaging as an example of where they had learned from celebrities. Their ability to sing phrases from the songs and repeat key health messages they contained indicated the videos had commanded attention and provided knowledge and perspectives that had been retained. We located on YouTube the video titles the pupils identified and evaluated the content, messaging and production concepts these celebrity-recorded music videos incorporated. All are good examples of the health promotion genre known as education entertainment, where educational content is intentionally included in professionally produced entertainment media to impart knowledge, create favorable attitudes and impact future behaviors. The importance of this genre is growing in parallel with the burgeoning influence of social media. Music videos resonate with youth, and celebrity recordings combine young people’s love of music with their fascination for the aura of celebrity. Hence, producing videos that combine an effective health message with celebrity endorsement offers potential as an innovative conduit for health promotion messaging among youth.
Thermographic cameras reveal high levels of crepuscular and nocturnal shore-based recreational fishing effort in an Australian estuary
Authors: Taylor S M , Blight S J , Desfosses C J , Steffe A S , Ryan K L , Denham A M , Wise B S 
Published: May 2018

Abstract
Although recreational fishing at night is a popular activity, crepuscular and nocturnal fishing effort and catches are often unaccounted for in fisheries assessments. Here, we present a method for estimating 24-h shore-based recreational fishing effort involving the analysis of data from dual-lens thermographic cameras. Cameras were installed at three sites along the foreshore in Peel-Harvey Estuary, a Ramsar Wetland in Western Australia. Stratified random sampling was used to select days for image analysis between March 2015 and February 2016 and examination of images enabled fishing effort to be calculated for the 12-month period. Crepuscular recreational fishing effort at the three sites ranged between 4.5% and 11.3% and nocturnal recreational fishing effort ranged between 6.1% and 26.9% of total recreational fishing effort. Crepuscular and nocturnal recreational fishing were more prevalent between November and March and occurred on both weekdays and weekend days. The majority of recreational fishers identified from the day-time images (96.5%) were targeting blue swimmer crabs (Portunus armatus) using scoop nets. Multiple lines of evidence suggest that most crepuscular and nocturnal activity involved the same method of fishing. The results demonstrate that restricting onsite recreational fishing surveys to daylight hours can lead to large underestimates of total fishing effort and total recreational catches within a fishery. Our method can easily be applied to other fisheries to justify the inclusion of night-time onsite sampling and to design cost-effective sampling strategies.
Error estimates of finite element method for semilinear stochastic strongly damped wave equation
Authors: Qi Ruisheng , Wang Xiaojie 
Published: May 2018

AbstractIn this paper we consider a semilinear stochastic strongly damped wave equation driven by additive Gaussian noise. Following a semigroup framework we establish existence, uniqueness and space-time regularity of a mild solution to such equation. Unlike the usual stochastic wave equation without damping the underlying problem with space-time white noise (Q = I) allows for a mild solution with a positive order of regularity in multiple spatial dimensions. Further, we analyze a spatio-temporal discretization of the problem, performed by a standard finite element method (FEM) in space and a well-known linear implicit Euler scheme in time. The analysis of the approximation error forces us to significantly enrich existing error estimates of semidiscrete and fully discrete FEMs for the corresponding linear deterministic equation. The main results show optimal convergence rates in the sense that the orders of convergence in space and in time coincide with the orders of the spatial and temporal regularity of the mild solution, respectively. Numerical examples are finally included to confirm our theoretical findings.
On Cogrowth, Amenability, and the Spectral Radius of a Random Walk on a Semigroup
Authors: Gray Robert D , Kambites Mark 
Published: May 2018

AbstractWe introduce two natural notions of cogrowth for finitely generated semigroups —one local and one global — and study their relationship with amenability and random walks. We establish the minimal and maximal possible values for cogrowth rates, and show that nonmonogenic-free semigroups are exactly characterised by minimal global cogrowth. We consider the relationship with cogrowth for groups and with amenability of semigroups. We also study the relationship with random walks on finitely generated semigroups, and in particular the spectral radius of the associated Markov operators (when defined) on $\ell _2$-spaces. We show that either of maximal global cogrowth or the weak Følner condition suffices for the spectral radius to be at least $1$; since left amenability implies the weak Følner condition, this represents a generalisation to semigroups of one implication of Kesten’s Theorem for groups. By combining with known results about amenability, we are able to establish a number of new sufficient conditions for (left or right) amenability in broad classes of semigroups. In particular, maximal local cogrowth left implies amenability in any left reversible semigroup, while maximal global cogrowth (which is a much weaker property) suffices for left amenability in an extremely broad class of semigroups encompassing all inverse semigroups, left reversible left cancellative semigroups and left reversible regular semigroups.
Simultaneous monitoring of transcription and translation in mammalian cell-free expression in bulk and in cell-sized droplets
Authors: Wang Shue , Majumder Sagardip , Emery Nicholas J , Liu Allen P 
Published: May 2018

Abstract
Transcription and translation are two critical processes during eukaryotic gene expression that regulate cellular activities. The development of mammalian cell-free expression (CFE) systems provides a platform for studying these two critical processes in vitro for bottom-up synthetic biology applications such as construction of an artificial cell. Moreover, real-time monitoring of the dynamics of synthesized mRNA and protein is key to characterize and optimize gene circuits before implementing in living cells or in artificial cells. However, there are few tools for measurement of mRNA and protein dynamics in mammalian CFE systems. Here, we developed a locked nucleic acid (LNA) probe for monitoring transcription in a HeLa-based CFE system in real-time. By using this LNA probe in conjunction with a fluorescent reporter protein, we were able to simultaneously monitor mRNA and protein dynamics in bulk reactions and cell-sized single-emulsion droplets. We found rapid production of mRNA transcripts that decreased over time as protein production ensued in bulk reactions. Our results also showed that transcription in cell-sized droplets has different dynamics compared to the transcription in bulk reactions. The use of this LNA probe in conjunction with fluorescent proteins in HeLa-based mammalian CFE system provides a versatile in vitro platform for studying mRNA dynamics for bottom-up synthetic biology applications.
Acellular Flowable Matrix in the Treatment of Tunneled or Cavity Ulcers in Diabetic Feet: A Preliminary Report
Authors: Campitiello Ferdinando , Mancone Manfredi , Della Corte Angela , Guerniero Raffaella , Canonico Silvestro 
Published: May 2018

ABSTRACT

OBJECTIVE:
The authors aimed to explore the feasibility and safety of an advanced, acellular, flowable wound matrix (FWM) in patients with diabetes-related cavity or tunnel lesions involving deep structures.

METHODS:
Patients with diabetic foot ulcers were hospitalized at the General and Geriatric Surgery Unit of the University of Campania in Naples, Italy, between March 2015 and December 2015. Twenty-three patients with tunneled or cavity ulcers were treated. The lesions were filled with the FWM. Surgical wound edges were either approximated with stitches or left to heal by secondary intention.

MAIN RESULTS:
After 6 weeks, 78.26% of patients completely healed after a single application of the FWM. The healing time for all healed wounds was 30.85 ± 12.62 days, or 26.11 ± 5.43 days in patients for whom wound edges were approximated by stitches, and 57.66 ± 3.05 days in the patients who healed by secondary intention (P = .01). Permanent tissue regeneration was observed in a high percentage of patients, and shorter healing time was achieved. Study authors observed a low rate of complications such as major amputation and increased hospitalization.

CONCLUSIONS:
The FWM seems ideal for tunneled and cavity ulcers with irregular geometry. This new porous matrix allows closure of the lesion while reducing healing time and demolition surgery.
Osteomyelitis: A Context for Wound Management
Authors: Groll Mary E. , Woods Timothy , Salcido Richard 
Published: May 2018

ABSTRACT
This educational activity reviews the pathogenesis of osteomyelitis and discusses practical considerations for diagnosis, treatment, and functional rehabilitation of pediatric and adult patients with osteomyelitic wounds. Antibiotic, surgical, and adjunctive treatments will be addressed. Emphasis is placed on consulting with infectious disease specialists and using evidence-based guidelines for antibiotic prescribing.

GENERAL PURPOSE:
To provide an overview of osteomyelitis.

TARGET AUDIENCE:
This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

LEARNING OBJECTIVES/OUTCOMES:
After completing this continuing education activity, you should be able to:
1. Distinguish the pathogenesis of osteomyelitis in children and adults.
2. Identify practical considerations for diagnosis and evidence-based treatment of osteomyelitis.
Development of a Novel Self-administered Cognitive Assessment Tool and Normative Data for Older Adults
Authors: Monsch Raphael J. , Burckhardt Amélie C. , Berres Manfred , Thomann Alessandra E. , Ehrensperger Michael M. , Steiner Luzius A. , Goettel Nicolai 
Published: May 2018

Background:
Preexisting cognitive impairment in surgical patients is one of the leading risk factors for adverse cognitive outcomes such as postoperative delirium and postoperative cognitive dysfunction. We developed a self-administered tablet computer application intended to assess the individual risk for adverse postoperative cognitive outcomes. This cross-sectional study aimed to establish normative data for the tool.

Materials and Methods:
Healthy volunteers aged 65 years and above were administered the Mini-Mental State Examination, Geriatric Depression Scale, and Consortium to Establish a Registry for Alzheimer’s Disease-Neuropsychological Assessment Battery to assess cognitive health. All subjects completed the tablet computer application without assistance. Primary outcome measure was the test performance. Regression models were built for each cognitive domain score with the covariates age, sex, and education in cognitively healthy subjects. Demographically adjusted standard scores (z-scores) were computed for each subtest.

Results:
A total of 283 participants (155 women, 128 men) were included in the final analysis. Participants’ age was 73.8±5.2 years (mean±SD) and their level of education was 13.6±2.9 years. Mini-Mental State Examination score was 29.2±0.9 points, Geriatric Depression Scale score was 0.4±0.7 points, and Consortium to Establish a Registry for Alzheimer’s Disease-Neuropsychological Assessment Battery total score was 98.7±5.7 points. Older age was associated with poorer performance in the visual recognition task and in Trail Making Test B (P<0.05 after Bonferroni-Holm adjustments).

Conclusions:
This study provides normative data for a novel self-administered tablet computer application that is ultimately designed to measure the individual risk for adverse postoperative cognitive outcomes in elderly patients.
Glasgow Coma Scale Score Fluctuations are Inversely Associated With a NIRS-based Index of Cerebral Autoregulation in Acutely Comatose Patients
Authors: Healy Ryan J. , Zorrilla-Vaca Andres , Ziai Wendy , Mirski Marek A. , Hogue Charles W. , Geocadin Romergryko , Radzik Batya , Palmisano Caitlin , Rivera-Lara Lucia 
Published: May 2018

Background:The Glasgow Coma Scale (GCS) is an essential coma scale in critical care for determining the neurological status of patients and for estimating their long-term prognosis. Similarly, cerebral autoregulation (CA) monitoring has shown to be an accurate technique for predicting clinical outcomes. However, little is known about the relationship between CA measurements and GCS scores among neurological critically ill patients. This study aimed to explore the association between noninvasive CA multimodal monitoring measurements and GCS scores.Methods:Acutely comatose patients with a variety of neurological injuries admitted to a neurocritical care unit were monitored using near-infrared spectroscopy–based multimodal monitoring for up to 72 hours. Regional cerebral oxygen saturation (rScO2), cerebral oximetry index (COx), GCS, and GCS motor data were measured hourly. COx was calculated as a Pearson correlation coefficient between low-frequency changes in rScO2and mean arterial pressure. Mixed random effects models with random intercept was used to determine the relationship between hourly near-infrared spectroscopy–based measurements and GCS or GCS motor scores.Results:A total of 871 observations (h) were analyzed from 57 patients with a variety of neurological conditions. Mean age was 58.7±14.2 years and the male to female ratio was 1:1.3. After adjusting for hemoglobin and partial pressure of carbon dioxide in arterial blood, COx was inversely associated with GCS (β=−1.12, 95% confidence interval [CI], −1.94 to −0.31,P=0.007) and GCS motor score (β=−1.06, 95% CI, −2.10 to −0.04,P=0.04). In contrast rScO2was not associated with GCS (β=−0.002, 95% CI, −0.01 to 0.01,P=0.76) or GCS motor score (β=−0.001, 95% CI, −0.01 to 0.01,P=0.84).Conclusions:This study showed that fluctuations in GCS scores are inversely associated with fluctuations in COx; as COx increases (impaired autoregulation), more severe neurological impairment is observed. However, the difference in COx between high and low GCS is small and warrants further studies investigating this association. CA multimodal monitoring with COx may have the potential to be used as a surrogate of neurological status when the neurological examination is not reliable (ie, sedation and paralytic drug administration).
How Do Hearing Aid Owners Respond to Hearing Aid Problems?
Authors: Bennett Rebecca J. , Laplante-Lévesque Ariane , Eikelboom Robert H. 
Published: May 2018

Background:
Although hearing aids can improve hearing and communication, problems that arise following the acquisition of hearing aids can result in their disuse. This study aimed to gather perspectives of hearing aid owners and hearing health care clinicians about how hearing aid owners respond to problems that arise following hearing aid fitting, and then use these perspectives to generate a conceptual framework to better understand these responses.

Methods:
Seventeen hearing aid owners and 21 hearing health care clinicians generated, sorted, and rated statements regarding how hearing aid owners respond to problems associated with hearing aid use. Concept mapping was used to identify key themes and to develop a conceptual framework.

Results:
Participants identified four concepts regarding how hearing aid owners respond to problems associated with hearing aids: (1) Seeking External Help; (2) Problem Solving; (3) Putting Up with Problems; and (4) Negative Emotional Response. Participants described behaviors of the clinician and significant others that influenced their decision to seek help for hearing aid problems. Participants recognized that these behaviors could either have a helpful or unhelpful impact.

Conclusions:
Despite the ongoing support offered to clients after they acquire hearing aids, they are hesitant to seek help from their clinician and instead engage in a myriad of helpful and unhelpful behaviors in response to problems that arise with their hearing aid. Previous positive or negative experiences with the clinic, clinician, or significant other influenced these actions, highlighting the influential role of these individuals’ in the success of the rehabilitation program. The data generated from this study suggests that clinicians could improve hearing aid problem resolution by providing technical and emotional support, including to significant others, and promoting client empowerment and self-management.
Comparing Two Hearing Aid Fitting Algorithms for Bimodal Cochlear Implant Users
Authors: Vroegop Jantien L. , Homans Nienke C. , van der Schroeff Marc P. , Goedegebure André 
Published: May 2018

Objectives:
To investigate the possible advantage of the use of a dedicated bimodal hearing aid fitting formula, the Adaptive Phonak Digital Bimodal (APDB), compared with a frequently used standard hearing aid fitting formula, the NAL-NL2. We evaluated the effects of bimodal hearing aid fitting on provided hearing aid gain and on bimodal auditory functioning in a group of experienced bimodal cochlear implant (CI) users. A second aim of our study was to determine the effect of broadband loudness balancing on the prescribed gain of those two fitting formulas.

Design:
This prospective study used a crossover design in which two fitting methods were compared varying in basic prescription formula (NAL-NL2 or APDB fitting formula). The study consisted of a three-visit crossover design with 3 weeks between sessions. Nineteen postlingually deafened experienced bimodal CI users participated in this study. Auditory functioning was evaluated by a speech in quiet test, a speech in noise test, and a questionnaire on auditory performance.

Results:
Significant differences between the two fitting formulas were found for frequencies of 2000 Hz and above. For these frequencies, less gain was provided by the APDB fitting formula compared with NAL-NL2. For the APDB fitting formula, a higher compression ratio for frequencies of 1000 Hz and above was found compared with the NAL-NL2 fitting formula. Loudness balancing did not result in large deviations from the prescribed gain by the initial fitting formula. Bimodal benefit was found for speech perception in quiet and for speech perception in noise. No differences in auditory performance were found between the two fitting formulas for any of the auditory performance tests.

Conclusions:
The results of this study show that CI users with residual hearing at the contralateral ear can benefit from bimodal stimulation, regardless of the fitting method that was applied. Although significant differences between the output and compression ratio of the NAL-NL2 and the APDB fitting formula existed, no differences in bimodal auditory performance were observed. Therefore, NAL-NL2 or the APDB fitting prescription both seem suited for bimodal fitting purposes. Additional loudness balancing has a marginal effect on the provided hearing aid output.