bluuebunny/crossref_metadata_2025_split huggingface dataset:
Edoxaban Monotherapy and Incidence of Transcatheter Heart Valve Leaflet Thrombosis — The Rotterdam Edoxaban (REDOX) Study
Authors: Adrichem Rik , van Wiechen Maarten P. , Knol Wiebe G. , Hokken Thijmen W. , Ooms Joris F. , van den Dorpel Mark M. P. , Verhemel Sarah , Kardys Isabella , Nuis Rutger‐Jan , Daemen Joost , Hirsch Alexander , Budde Ricardo P. J. , Van Mieghem Nicolas M. 
Published: November 2024

ABSTRACTBackgroundTrials comparing non‐vitamin K oral anticoagulant (NOAC) versus antiplatelet‐based strategies have shown a reduction of subclinical leaflet thrombosis at the cost of increased mortality and major‐bleedings. NOACs were often combined with antiplatelet therapy.AimsThe Rotterdam Edoxaban (REDOX) study aimed to evaluate the impact of edoxaban monotherapy on the incidence of hypo‐attenuated leaflet thickening (HALT) and reduced leaflet motion (RLM) and to evaluate safety in terms of mortality, thromboembolic events and major bleeding.MethodsThe REDOX study is a single‐arm, open‐label trial including patients after successful transcatheter aortic valve implantation (TAVI) with no formal indication for oral anticoagulation or dual antiplatelet therapy. Patients received edoxaban monotherapy for 3 months, followed by multislice computed tomography (MSCT). The primary endpoint was the occurrence of HALT. Clinical follow‐up continued up to 1 year after TAVI.ResultsWe included 58 patients, of which 50 reached study completion including MSCT scanning and eight withdrew consent before end of study. At 3‐months follow‐up, HALT of any grade was detected in 12.0% (95% confidence interval (CI): 5.0%–23.1%) of patients. HALT grade ≥ 3 occurred in 4.0% (95% CI: 0.8%–12.2%) of patients. At 1 year follow‐up, all patients were alive and free of disabling strokes. Three patients had a non‐disabling stroke and one patient had a major bleeding.ConclusionsIn the REDOX study, edoxaban monotherapy after TAVI was associated with a 12.0% incidence of any HALT and a 4.0% incidence of HALT grade ≥ 3. HALT was not associated with clinical events.
Dupilumab‐Induced Erythrodermic Psoriasiform Dermatitis in Chronic Actinic Dermatitis: Case Report and Innovative Treatment Approach
Authors: Khodeir Joe , Habre Maya 
Published: November 2024

ABSTRACTThe off‐label use of dupilumab has proven to be an effective treatment option for severe chronic actinic dermatitis (CAD). We present the first case of CAD presenting with dupilumab‐induced erythrodermic psoriasiform dermatitis. A modified, spaced dupilumab dosing regimen, combined with cyclosporine, successfully managed both conditions, offering a promising strategy for managing dupilumab adverse effects while maintaining control over chronic actinic dermatitis.
A Case of Recurrent Pemphigus Foliaceus Following Noncompliance to Medication
Authors: Ali Masab , Ahmad Muhammad Husnain , Imran Ali , Ahmad Uswa , Naseer Ahmad Rehan 
Published: November 2024

ABSTRACTPemphigus foliaceus (PF) is a rare autoimmune blistering disorder requiring consistent immunosuppressive therapy for management. A 66‐year‐old male with a history of PF presented with worsening blisters and erosions after discontinuing medication. The patient had flaccid bullae and erosions on the face, scalp, chest, and back. Histopathology confirmed PF. Treatment with oral prednisolone, azathioprine, and reinitiation of dexamethasone‐cyclophosphamide pulse (DCP) therapy led to disease remission. This case underscores the importance of adherence to immunosuppressive therapy in PF management. It also highlights the role of affordable treatment regimens in ensuring patient compliance and successful outcomes.
Analysis of Free Oligosaccharides in Urine by High‐Performance Liquid Chromatography–Tandem Mass Spectrometry
Authors: Sharer J. Daniel , Huang Rongrong , Wood Timothy , Huffman Paula , Yan Yang , Zimmerman Chelsea , Pollard Laura 
Published: November 2024

AbstractOligosaccharidoses are a group of lysosomal storage disorders characterized by abnormal storage and excretion of incompletely processed glycan structures. As with other inherited metabolic disorders, early diagnosis and initiation of treatment are essential for optimizing outcomes. Biochemical investigation of suspected oligosaccharidoses has traditionally included thin layer chromatography to detect the presence of disease‐specific free oligosaccharides in urine; however, this qualitative method has long been known to have limited sensitivity and specificity. In this unit, a quantitative technique for measuring oligosaccharides utilizing high‐performance liquid chromatography–tandem mass spectrometry is described, which provides substantial improvements over other methods, in terms of sensitivity and specificity; moreover, it is relatively inexpensive, accessible, and requires significantly less time, effort, sample volume, and reagents to perform. © 2024 Wiley Periodicals LLC.Basic Protocol: Analysis of urinary FOS by HPLC–MS/MS
The Influence of Patient‐, Site‐, and Implant‐Related Factors on Marginal Bone Levels of Dental Implants in a Rural Population in China: A Retrospective Study
Authors: Khehra Anahat , Zannar Ossi , Samet Nachum , Levin Liran 
Published: November 2024

ABSTRACTObjectivesLimited research is available on implant treatment outcomes in rural populations. This may be due to the presence of various barriers, such as access to oral health care, resources, health literacy, and education. The aim of this study was to evaluate the influence of patient‐, site‐, and implant‐related factors on marginal bone levels of dental implants in a rural population in China.Material and MethodsA retrospective study was conducted using data from a private dental office. Subjects included in this study received dental implants as part of their routine dental treatment. Information on age, gender, smoking status, diabetes, heart disease, jaw location, restorative type, loading protocol, survival rate, implant length, and diameter was collected. Marginal bone loss was recorded as the largest value at either the mesial or distal aspect on peri‐apical radiographs. Descriptive and inferential statistics were performed along with linear regression analysis.ResultsOverall, 428 implants were placed in 90 subjects over an average follow‐up period of 453 days. No implant failures were recorded. The average marginal bone loss was 0.10 mm, with 80.6% of implants showing no marginal bone loss. The extent of marginal bone loss was greater in the mandible (0.13 ± 0.25) than in the maxilla (0.08 ± 0.19). An increase in implant diameter by 1 mm resulted in 0.08 mm of marginal bone loss, indicating wider diameter implants are associated with more bone loss. Age was also positively correlated with marginal bone loss, increasing by 0.002 mm per year. No differences were found for gender, smoking, diabetes, heart disease, restoration type, and immediate loading.ConclusionsDental implant therapy in a rural Chinese population demonstrated high survival rates and minimal marginal bone loss. Factors such as age, implant location, and diameter influenced bone loss. This study fills a critical gap in understanding implant outcomes specifically within rural settings, highlighting the need for tailored approaches to enhance patient access and care in these communities. Further research is needed to explore these relationships and assess implant outcomes in rural populations.
Design of a Novel CMOS Transimpedance Amplifier Based on a Current Mirror
Authors: Shaaban Aya M. , Sharroush Sherif M. , Abdalla Yasser , Nafea Sherif F. 
Published: November 2024

ABSTRACTThe transimpedance amplifier (TIA) is an essential component in optical communication systems. It converts the photodiode current to a voltage for further processing. In this paper, a novel CMOS current‐mirror‐based TIA is proposed. Its suitability to optical communication systems is verified. The current‐mirror topology is chosen due to its low input resistance and highly linear current amplification. The proposed TIA employs negative feedback and shunt‐inductive peaking to extend the bandwidth. Three configurations of the shunt‐inductive peaking are explored: one with passive inductors and two with active inductors. The proposed TIA is verified by simulation using the 45‐nm CMOS technology with a 1‐V supply and 1‐pF photodiode capacitance with the key performance trade‐offs discussed. A figure of merit (FoM) is introduced to evaluate the performance of the proposed TIA. The simulation results of the proposed TIA with passive inductors show a gain of 30.6 dB, a 3‐dB bandwidth of 2.8 GHz, and a power consumption of 1.63 mW, with an input‐referred noise current of 23.55 pA/√Hz.
A Next Generation of Hierarchical Bayesian Analyses of Hybrid Zones Enables Model‐Based Quantification of Variation in Introgression in R
Authors: Gompert Zachariah , DeRaad Devon A. , Buerkle C. Alex 
Published: November 2024

ABSTRACTHybrid zones, where genetically distinct groups of organisms meet and interbreed, offer valuable insights into the nature of species and speciation. Here, we present a new R package, bgchm, for population genomic analyses of hybrid zones. This R package extends and updates the existing bgc software and combines Bayesian analyses of hierarchical genomic clines with Bayesian methods for estimating hybrid indexes, interpopulation ancestry proportions, and geographic clines. Compared to existing software, bgchm offers enhanced efficiency through Hamiltonian Monte Carlo sampling and the ability to work with genotype likelihoods combined with a hierarchical Bayesian approach, enabling inference for diverse types of genetic data sets. The package also facilitates the quantification of introgression patterns across genomes, which is crucial for understanding reproductive isolation and speciation genetics. We first describe the models underlying bgchm and then provide an overview of the R package and illustrate its use through the analysis of simulated and empirical data sets. We show that bgchm generates accurate estimates of model parameters under a variety of conditions, especially when the genetic loci analyzed are highly ancestry informative. This includes relatively robust estimates of genome‐wide variability in clines, which has not been the focus of previous models and methods. We also illustrate how both selection and genetic drift contribute to variability in introgression among loci and how additional information can be used to help distinguish these contributions. We conclude by describing the promises and limitations of bgchm, comparing bgchm to other software for genomic cline analyses, and identifying areas for fruitful future development.
State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases
Authors: Van Linthout Sophie , Stellos Konstantinos , Giacca Mauro , Bertero Edoardo , Cannata Antonio , Carrier Lucie , Garcia‐Pavia Pablo , Ghigo Alessandra , González Arantxa , Haugaa Kristina H. , Imazio Massimo , Lopes Luis R. , Most Patrick , Pollesello Piero , Schunkert Heribert , Streckfuss‐Bömeke Katrin , Thum Thomas , Tocchetti Carlo Gabriele , Tschöpe Carsten , van der Meer Peter , van Rooij Eva , Metra Marco , Rosano Giuseppe M.C. , Heymans Stephane 
Published: November 2024

AbstractGene therapy has recently become a reality in the treatment of cardiovascular diseases. Strategies to modulate gene expression using antisense oligonucleotides or small interfering RNA are proving to be safe and effective in the clinic. Adeno‐associated viral vector‐based gene delivery and CRISPR‐Cas9‐based genome editing have emerged as efficient strategies for gene delivery and repair in humans. Overall, gene therapy holds the promise not only of expanding current treatment options, but also of intervening in previously untackled causal disease mechanisms with little side effects. This scientific statement provides a comprehensive overview of the various modalities of gene therapy used to treat heart failure and some of its risk factors, and their application in the clinical setting. It discusses specifically the possibilities of gene therapy for hereditary heart diseases and (non)‐genetic heart failure. Furthermore, it addresses safety and clinical trial design issues and challenges for future regulatory strategies.
Stochastic stability analysis method for doubly fed generator sets considering random blade stress
Authors: Chen Wei , Wang Bo , Wei Zhanhong , Li Qiangqiang 
Published: November 2024

AbstractWith the increasing capacity of doubly fed induction generators (DFIGs), the diameter of the wind turbine is increasing, the blades are getting longer and longer, and in the process of power generation, the tower shadow effect as well as the role of wind shear are more obvious, and the random blade stresses caused by this is also getting bigger. Random blade stresses cause random and cyclic fluctuations in the power generated by the wind turbine, and power fluctuations often cause voltage flicker, which affects the control system and power quality. To address the impact of random blade stresses on the grid‐connected stability of DFIG, the results of the traditional stability analysis methods may be too conservative or lead to too high a dimensionality to be analyzed. To solve the above problems, this paper proposes a grid‐connected stochastic stability analysis method for DFIG sets considering random blade stresses based on the stochastic averaging method under the Hamiltonian system. a stochastic dynamics model of the doubly fed wind farm was established by considering random blade stress. Subsequently, using the proposed generalized Hamiltonian principle, the model and energy functions in the proposed Hamiltonian form H, based on the stochastic averaging method (SAM), were established to obtain the system energy diffusion equation. Probability density function and regional stability probability were obtained from explicit expressions of the mean and regression square root processes. The drift and diffusion coefficients were obtained using the SAM, and the backward Kolmogorov equation was derived from the Ito equation to obtain the conditional reliability function and the probability density of the first crossing time. Finally, the effects of torque fluctuations with different stochastic intensities on the grid‐connected stability of doubly fed wind farms were investigated, and the effectiveness of the proposed generalized Hamiltonian SAM applied to the stochastic stability analysis of DFIG was verified by numerical analysis and Monte Carlo simulation. This provides a theoretical foundation for analyzing the grid‐connected stability of DFIG affected by random blade stresses.
Advanced high‐precision methodology for assessing sediment erosion in Pelton turbine buckets
Authors: Qin Bei , Chang Xiao , Pang Jiayang , Yu Zhishun , Liu Jitao , Deng Wanquan , Zhang Li , Yao Bing , Liu Xiaobing 
Published: November 2024

AbstractDeveloping highly accurate sediment erosion testing methods for Pelton turbine overflow components is challenging due to their irregularly curved surfaces. In this study, we designed a method to evaluate the sediment erosion of the Pelton turbine bucket using test blocks with an accuracy of 0.0001 g. In addition, we conducted sediment erosion tests on a model Pelton turbine and conducted an in‐depth study on the installation design of the turbine runner and bucket, the design of the erosion test blocks, and the arrangement; we analyzed sediment abrasion distribution on the bucket's working surface. Our test results show that the bucket splitter edge, as well as the root of the working surface, are heavily worn. The maximum erosion rate of the working face is 0.7669 μm/h, and the maximum erosion rate of the splitter edge is close to 5 μm/h, which is highly consistent with the distribution of sediment erosion observed in Pelton turbines operating under sandy river conditions. This test method is essential for examining sediment erosion in Pelton turbines.
Early Failure Diagnosis of Scraper Conveyor Gearboxes Based on DS Evidence Theory and Multimodal Data Fusion
Authors: Feng Long , Ding Zeyu , Zhang Qiang , Zhou Feng , Su Jin Peng , Wang Yang , Liu Xinye , Yin Yibing 
Published: November 2024

ABSTRACTA scraper conveyor is one of the important equipment to ensure reliable, efficient and stable mining and transportation of coal. As the most important transmission system of the scraper conveyor, the gearbox takes the role of transmitting power and torque. Due to the influence of working conditions in underground coal mines, the gear transmission system is often subject to the impact of nonuniform large loads, which is very prone to failures, and affected by environmental interference, it is difficult to detect the early abnormal signals of the scraper conveyor gearbox in the conventional industrial scenarios of fault monitoring methods. To ensure the stability and reliability of its work, this paper carries out the research on the multi‐parameter fusion of gearbox early fault diagnosis method under strong background noise interference. Aiming at the problem that the change of fluid physical and chemical characteristic parameters can reflect the early health condition of the gear transmission system and the single vibration signal is difficult to be extracted under the strong background noise, a model based on the fluid physical and chemical characteristic parameters and vibration signals is constructed by utilizing the RBF neural network and the Random Forest algorithm, and the body of evidence of the two models is fused at the decision‐making level through the DS evidence theory, which forms the fluid‐vibration multi‐parameter fusion judgment of the early fault diagnosis method of scraper conveyor gearbox. Through comparison, it is found that compared with the fusion methods, such as high‐dimensional variational self‐encoder, and single diagnosis methods, such as the Random Forest Algorithm, the method researched in this paper is more suitable for the early fault warning of the scraper conveyor gearbox of the well coal mine, and the experimental validation finds that the average accuracy rate of the early fault recognition can be up to 96.6%.
Wellbore Stability Prediction Model for Complex Reservoirs: Application to the Bozi Gas Field in the Tarim Basin
Authors: Liu Yingjun , Xian Chenggang , Zhang Hui , Yin Guoqing , Xu Ke , Wang Zhimin , Li Houjun , Shibo Zhong 
Published: November 2024

ABSTRACTThe primary objective of this paper is to propose a method for predicting the safe mud weight window within the Bozi gas field situated in the Tarim Basin and establish a 3D wellbore stability model. The approach combines Mogi–Coulomb criterion using intermediate stress for wellbore shear failure. It considers rock shear breakdown in fracture pressure calculations and predicts reservoir shear slip with Jaeger criterion and drilling fluid invasion on the weak surface in calculating wellbore tensile failure. The study finds that instability in the well wall of this block is not solely due to the intermediate stress criterion or shear fracture of intact rock. Instead, during drilling with high‐density fluid, the weak surface (fracture) undergoes shear‐slip damage before intact rock. The collapse is a result of the interplay between bit replacement, dynamic drilling loads, and drilling fluid intrusion, causing tensile rupture on the weak surface and repeated fluid leakage. Analysis of wellbore instability in 16 wells within ultra‐deep complex formations shows that the collapse pressure prediction accuracy is 87.5%, and the loss pressure prediction accuracy is 93.7%. Compared to traditional methods, this approach is more accurate and practical, providing essential guidance for resolving wellbore instability issues in drilling operations. In conclusion, this paper introduces a novel and more precise method for predicting the safe mud weight window in the Bozi gas field.
Petrogenesis of Silurian Granitoids in the Western Segment of the North Qilian Accretionary Belt, China: Insights Into the Closure of the Northernmost Branch of the Proto‐Tethys Ocean
Authors: He Weidong , Dong Yunpeng , Sun Jiaopeng , He Lei , Li Zonglin , Qi Yukun , Ye Kai , Wang Zhigang , Wang Teng 
Published: November 2024

ABSTRACTThe North Qilian Accretionary Belt, situated at the northernmost extent of the Proto‐Tethys tectonic domain, preserves key tectonic events such as Proto‐Tethys Ocean subduction and accretion. Despite ongoing debates about the closure mechanisms and timing of the North Qilian Ocean, our study presents novel findings on granitoids from the Changma region in the western segment of the North Qilian Accretionary Belt. Zircon U–Pb dating indicates an emplacement age of 436 Ma for the Qingshixia pluton and 425 Ma for the Heixialao pluton. The ε

Hf
(t) values of the Qingshixia granodiorite range from +8.25 to +10.89, with TDM2 model ages estimated between 614 and 716 Ma. In contrast, the ε

Hf
(t) values of the Heixialao monzogranite range from +1.79 to +4.48, with TDM2 model ages spanning from 1127 to 1291 Ma. The Qingshixia granodiorite displays adakitic traits, characterised by high Sr, low Y, low Yb, and a low K2O/Na2O ratio, whilst the Heixialao monzogranite exhibits peraluminous, high‐potassium calc‐alkaline features. The low concentrations of Ni and Cr, along with moderate Mg# values, suggest that the Qingshixia granodiorite likely originated from the partial melting of a subducting slab. By comparison with experimental melts, the relatively low Rb/Ba and Rb/Sr ratios and higher zircon saturation temperatures of Heixialao monzogranite suggest that it may have formed from partial melting of the mafic middle and lower crust. Integrating these findings with regional geological features and differences between east and west segments, we propose that the western segment of the North Qilian Ocean basin may have closed during the Late Silurian, contributing to a diachronic closure process from east to west and offering insights into the tectonic evolution of the Proto‐Tethys Ocean.
Hypofractionated Accelerated Radiotherapy for Head and Neck Cancer in Fragile Patients
Authors: Salvador Segado‐Guillot , María Jesús García‐Anaya , María Dolores Toledo‐Serrano , Ángel Calvo‐Tudela , Patricia Prieto‐Granados , María Dolores Torres‐Tabanera , José Antonio Medina‐Carmona , Jaime Gómez‐Millán 
Published: November 2024

ABSTRACTBackgroundRadiotherapy combined with chemotherapy is the treatment of choice for locally advanced non‐metastatic head and neck cancer. Elderly and frail patients cannot always tolerate this therapy and no clear guidelines exist for their treatment. This retrospective study aims to analyze the efficacy and safety of hypofractionated radiotherapy for these patients.MethodsA retrospective analysis of 65 patients treated with hypofractionated radiotherapy, using a regimen of 57.5 Gy in 23 fractions of 2.5 Gy.ResultsMost patients completed the prescribed treatment. Overall survival at 2 and 5 years was 55% and 33%. Locoregional control at 2 and 5 years was 76% and 51%, respectively. Performance status was an independent prognostic factor (p = 0.05).ConclusionsThis radiotherapy schedule was well tolerated, showing a high rate of locoregional control and shortening the overall treatment time. Prospective studies are necessary to establish the most effective treatment for frail patients.