bluuebunny/crossref_metadata_2025_split huggingface dataset:
Embodied time: Time production in advanced Quadrato and Aikido practitioners
Authors: Ben‐Soussan Tal Dotan , Glicksohn Joseph , De Fano Antonio , Mauro Federica , Marson Fabio , Modica Manuela , Pesce Caterina 
Published: January 2019

AbstractOver the last few years, several studies have investigated the possible effects of mindfulness meditation on time perception. Mindfulness meditation has been linked to both longer time production (TP) and increased bodily perception, and bodily processes are in turn thought to lie at the core of human time perception. Nevertheless, the connection between mindful movements (MMs; i.e., specific types of mind–body coordination‐demanding physical activity) and time perception has been ignored. Consequently, in the current study we examined the effect of MMs on TP. A mixed observational study design was adopted to investigate whether (1) the extensive practice of MMs is associated with longer TP and interlimb coordination efficiency, and (2) there is a relationship between these two variables. Thirty‐four healthy adults volunteered, including 11 Aikido and nine advanced Quadrato Motor Training (aQMT) practitioners, and 14 physically non‐active controls. Practitioners of aQMT had significantly longer produced durations in contrast to the Aikido and control groups. In addition, longer produced duration was associated with increased coordination efficiency. In conclusion, the current results are in line with previous studies linking embodied time and mindful meditation, and suggest the importance of incorporating movement meditation, especially in the context of time estimation and the self.
Multiresidue Determination of Six Pesticide Adjuvants in Characteristic Minor Crops Using QuEChERS Method and Gas Chromatography‐Mass Spectrometry
Authors: Qi Yan , Ma Cong , Wan Mengfei , Liu Zhongdong , Zheng Lufei , Jin Fen , Jin Maojun , She Yongxin , Wang Jing , Wang Shanshan 
Published: January 2019

AbstractA new multiresidue analysis method using a quick, easy, cheap, effective, rugged, and safe (QuEChERS) procedure for the determination of 6 pesticide adjuvants (toluene, p‐xylene, o‐xylene, m‐xylene, N, N‐dimethylformamide (DMF) and dimethyl sulphoxide (DMSO) in characteristic minor crops was developed via gas chromatography‐mass spectrometry (GC‐MS). Matrices, including lily bulb, millet, and Chinese yam, were extracted with CH3CN/CH3CN‐H2O and then cleaned up by primary secondary amine (PSA), followed by GC‐MS analysis with selected ion monitoring (SIM) mode. Under the optimal conditions, the established QuEChERS‐GC/MS method showed good linearity (r>0.998) for all targets with limits of detection of 0.001‐0.005 mg kg‐1 for benzene compounds, 0.012‐0.022 mg kg‐1 for DMF, and 0.012‐0.024 mg kg‐1 for DMSO, respectively. The average recoveries in the three characteristic minor crop samples ranged from 72.9% to 94.9% with relative standard deviations from 2.4% to 9.9%. The method is demonstrated to be accurate, sensitive, and convenient and thus could be applied for routinely monitoring multiresidues of pesticide adjuvants in agro‐products.
Internet‐delivered psychological treatments: from innovation to implementation
Authors: Andersson Gerhard , Titov Nickolai , Dear Blake F. , Rozental Alexander , Carlbring Per 
Published: January 2019

Internet interventions, and in particular Internet‐delivered cognitive behaviour therapy (ICBT), have existed for at least 20 years. Here we review the treatment approach and the evidence base, arguing that ICBT can be viewed as a vehicle for innovation. ICBT has been developed and tested for several psychiatric and somatic conditions, and direct comparative studies suggest that therapist‐guided ICBT is more effective than a waiting list for anxiety disorders and depression, and tends to be as effective as face‐to‐face CBT. Studies on the possible harmful effects of ICBT are also reviewed: a significant minority of people do experience negative effects, although rates of deterioration appear similar to those reported for face‐to‐face treatments and lower than for control conditions. We further review studies on change mechanisms and conclude that few, if any, consistent moderators and mediators of change have been identified. A recent trend to focus on knowledge acquisition is considered, and a discussion on the possibilities and hurdles of implementing ICBT is presented. The latter includes findings suggesting that attitudes toward ICBT may not be as positive as when using modern information technology as an adjunct to face‐to‐face therapy (i.e., blended treatment). Finally, we discuss future directions, including the role played by technology and machine learning, blended treatment, adaptation of treatment for minorities and non‐Western settings, other therapeutic approaches than ICBT (including Internet‐delivered psychodynamic and interpersonal psychotherapy as well as acceptance and commitment therapy), emerging regulations, and the importance of reporting failed trials.
Heterologous expression of AoD9D enhances salt tolerance with increased accumulation of unsaturated fatty acid in transgenic Saccharomyces cerevisiae
Authors: Li Haoran , Ma Long , Hu Zhihong , Tu Yayi , Jiang Chunmiao , Wu Qinqin , Han Jizhong , Zeng Bin , He Bin 
Published: January 2019

Abstract
Salt stress can trigger several physiological responses in microorganisms such as the increasing accumulation of unsaturated fatty acid, which was biosynthesized by delta-9 fatty acid desaturases (D9D) at the first step. In the present study, two D9D genes, designated AoD9D1 and AoD9D2, were isolated from Aspergillus oryzae. The expression analysis showed that AoD9D1 and AoD9D2 were upregulated under salt stress. To investigate the function of AoD9D, transgenic Saccharomyces cerevisiae strains that heterologously expressed AoD9D were exposed to salinity condition. These transgenic strains exhibited greater tolerance to salt stress than wild-type strains, and the heterologous expression of AoD9D increased the content in unsaturated fatty acids as compared to control cells. Moreover, AoD9D1 and AoD9D2 both contained fatty acid desaturase (FAD) and cytochrome b5-like Heme/Steroid-binding domains (Cyt-b5). S. cerevisiae separately transformed with the gene fragments coding for the FAD and Cyt-b5 domains in the AoD9D1 protein grew better and accumulated a higher concentration of unsaturated FAs than the control. Altogether, the heterologous expression of AoD9D enhanced the tolerance of transgenic S. cerevisiae to high salinity stress with increased accumulation of unsaturated fatty acid. The results provide some practical basis for the successful development of salt-tolerant fermentation microorganisms.
In Defence of the Shareability of Fregean Self-Thought
Authors: Verdejo Víctor M. 
Published: January 2019

AbstractConsider the Unshareability View, namely, the view that first person thought or self-thought—thought as typically expressed via the first person pronoun—is not shareable from subject to subject. In this article, I (i) show that a significant number of Fregean and non-Fregean commentators of Frege have taken the Unshareability View to be the default Fregean position, (ii) rehearse Frege’s chief claims about self-thought and suggest that their combination entails the Unshareability View only on the assumption that there is a one-to-one correspondence between way of thinking and thought-individuating cognitive value, (iii) outline an account of self-thought that rejects the assumption and keeps intact all of Frege’s chief claims, and (iv) respond to a number of worries to the effect that this proposal yields undesirable results from the point of view of the individuation of self-thought at the level of cognitive value.
The Timing of Teenage Births: Estimating the Effect on High School Graduation and Later-Life Outcomes
Authors: Schulkind Lisa , Sandler Danielle H. 
Published: January 2019

Abstract
We examine the long-term outcomes for a population of teenage mothers who give birth to their children around the end of high school. We compare the mothers whose high school education was interrupted by childbirth (because the child was born before her expected graduation date) with mothers who did not experience the same disruption to their education. We find that mothers who gave birth during the school year are 5.4 percentage points less likely to complete their high school education, are less likely to be married, and have more children than their counterparts who gave birth just a few months later. The wages for these two sets of teenage mothers are not statistically different, but with a lower likelihood of marriage and more children, the households of the treated mothers are more likely to fall below the poverty threshold. Although differences in educational attainment have narrowed over time, the differences in labor market outcomes and family structure have remained stable.
Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease
Authors: Xiong Feng , Ge Wei , Ma Chao 
Published: January 2019

AbstractIntroductionWe investigated the proteomic profiles of amyloid plaques (APs) from Alzheimer's disease (AD) and age‐matched non‐AD brains and APP/PS1 transgenic model mice.MethodsAPs and adjacent control regions were collected from fresh‐frozen brain sections using laser capture dissection. Proteins were quantitated using tag‐labeling coupled high‐throughput mass spectra.ResultsOver 4000 proteins were accurately quantified, and more than 40 were identified as highly enriched in both AD and non‐AD APs, including apoE, midkine, VGFR1, and complement C4. Intriguingly, proteins including synaptic structural proteins and complement C1r, C5, and C9 were found to be upregulated in AD APs but not non‐AD APs. Moreover, the proteomic pattern of AD APs was distinct from APP/PS1 APs and exhibited correlation with aging hippocampus.DiscussionOur results provide new insight into AP composition. We demonstrate unexpected differences between AD, non‐AD, and APP/PS1 mouse APs, which may relate to different pathological processes.
Olympe de Gouges versus Rousseau: Happiness, Primitive Societies, and the Theater
Authors: BERGÈS SANDRINE 
Published: January 2019

AbstractInLe Bonheur Primitif(1789), Olympe de Gouges takes on Rousseau's account of the evolution of human society in his first twoDiscourses, and she argues that primitive human beings were not only happy, but also capable of virtue. I argue that in that text, Gouges offers a contribution to the eighteenth-century debate on human progress that is distinct from Rousseau's in that it takes seriously the contribution of women and families to human happiness and progress. I show how the concept of emulation plays an important role in Gouges's analysis, both in her account of primitive societies and of the theater, and argue that she uses it to bridge the gap between primitive happiness and future progress.
The elongation of very long-chain fatty acid 6 gene product catalyses elongation ofn-13 : 0 andn-15 : 0 odd-chain SFA in human cells
Authors: Wang Zhen , Wang Dong Hao , Goykhman Yuliya , Yan Yuanyuan , Lawrence Peter , Kothapalli Kumar S. D. , Brenna J. Thomas 
Published: January 2019

AbstractNormal odd-chain SFA (OCSFA), particularly tridecanoic acid (n-13 : 0), pentadecanoic acid (n-15 : 0) and heptadecanoic acid (n-17 : 0), are normal components of dairy products, beef and seafood. The ratio ofn-15 : 0:n-17 : 0 in ruminant foods (dairy products and beef) is 2:1, while in seafood and human tissues it is 1:2, and their appearance in plasma is often used as a marker for ruminant fat intake. Human elongases encoded by elongation of very long-chain fatty acid (ELOVL)1, ELOVL3, ELOVL6 and ELOVL7 catalyse biosynthesis of the dominant even-chain SFA; however, there are no reports of elongase function on OCSFA. ELOVL transfected MCF7 cells were treated withn-13 : 0,n-15 : 0 orn-17 : 0 (80 µm) and products analysed. ELOVL6 catalysed elongation ofn-13 : 0→n-15 : 0 andn-15 : 0→n-17 : 0; and ELOVL7 had modest activity towardn-15 : 0 (n-15 : 0→n-17 : 0). No elongation activity was detected forn-17 : 0→n-19 : 0. Our data expand ELOVL specificity to OCSFA, providing the first molecular evidence demonstrating ELOVL6 as the major elongase acting on OCSFAn-13 : 0 andn-15 : 0 fatty acids. Studies of food intake relying on OCSFA as a biomarker should consider endogenous human metabolism when relying on OCSFA ratios to indicate specific food intake.
Rewriting theReich: German Women Journalists as Transnational Mediators for Germany's Rehabilitation
Authors: Barton Deborah 
Published: January 2019

AbstractThis article looks at the transnational impact of two diaries written by the female German journalists Ruth Andreas-Friedrich and Ursula von Kardorff, whose journals shed light on German wartime experiences, resistance activities, and, to a lesser extent, the press. In the postwar years, both journalists sought to influence (West) Germany's relationship with its former enemies, in particular the United States. In their autobiographical writing, they presented both an image of Germany as a victim of Nazism, as well as an early acknowledgment of German crimes. In this way, they achieved a balanced narrative that received a positive reception from American and German audiences. Though the ways in which Friedrich and Kardorff presented aspects of journalism and everyday life in the Third Reich were not unique, their dual identity as women and journalists underlay their ability to act as “legitimate” mediators for Germany's rehabilitation. Western allied occupation authorities and overseas audiences viewed them, in contrast to men, as largely apolitical because they were women, and as objective witnesses because they were journalists. Through their autobiographical writings, both journalists situated themselves among the predominantly male US and German elites devoted to developing amicable relations between the two countries via soft-power diplomacy.
East Germany's Red Woodstock: The 1973 Festival between the “Carnivalesque” and the Everyday
Authors: White Katharine 
Published: January 2019

AbstractScholars often depict the 1973 World Festival of Youth and Students—or, more colloquially, the Red Woodstock—as a momentary “departure” or “break” from everyday life, when the German Democratic Republic (GDR) briefly opened its borders to the youth of the world. Similarly, they suggest that, when the festival's nine days of festivities came to an end, the “pathos of revolution” disappeared just as quickly as it had come about, resulting in a return to the restraints of everyday life behind the “Iron Curtain.” By contrast, this article reconsiders the festival's significance by adopting an analytical framework from postsocialist theorists. In doing so, it reconceptualizes the Red Woodstock as a moment of globalized influences and youth engagement that not only reflected shifting societal norms, but also the East German state's commitment to international socialist solidarity. Soviet theorist Mikhail Bakhtin’s work on the “upside-down” nature of the carnival, as well as on society’s “grotesque body,” is useful in this regard, as it sets in sharp relief the extent to which one of the East German state’s greatest challenges resulted from its own embrace of international socialism. This was the case as young people from the GDR and beyond transformed the East German capital through a subtle appropriation, transformation, and even subversion of the state-generated discourse on international solidarity, in ways that had a lasting effect during the late socialist period.
‘The only real magic’: enchantment and disenchantment in music's modernist ordinary
Authors: Loeffler Zachary 
Published: January 2019

AbstractThis essay tracks a predominant fantasy of music in global liberal-capitalist culture: music as ‘the only real magic’. Although discussion of music's ‘magic’ has been characterized as a vestige of Romanticism, I argue that it became a cornerstone of ordinary/everyday music discourse circa 1900, around the time that sociologists defined modernity as mostly bereft of magic and configured the aesthetic as its remaining stronghold. Juxtaposing claims of magic in ordinary music discourse with a coeval archive of these ‘disenchantment’ narratives, I trace music's institutionalization as magic in the historical moment from around 1900 to the present. This history reveals that music remains commonly experienced as ‘the only real magic’ insofar as it offers deeply ameliorative forms of affective connection felt to be scarce in other domains. Accordingly, it indicates the immense healing power that music has accrued particularly over the last century while also adumbrating the conditions of scarcity from which this potency has emerged.
Sample magic: (conjuring) phonographic ghosts and meta-illusions in contemporary hip-hop production
Authors: Exarchos Michail 
Published: January 2019

AbstractSampling has been criticised as ‘a mixture of time-travel and seance’, ‘the musical art of ghost co-ordination and ghost arrangement’, and a process that ‘doubles (recording's) inherent supernaturalism’ (Reynolds, S., 2012,Retromania: Pop Culture's Addiction to its Own Past, London, Faber and Faber, pp. 313–14). Yet out of all the sample-based music forms, hip-hop receives the lion's share of attention in popular music literature; critics are puzzled by its appeal, scholars identify a plethora of problems in its function, and practitioners and audiences alike are mesmerised by its effect. Rap producers attribute an inherent ‘magic’ to working with past phonographic samples and fans appear spellbound by the resulting ‘supernatural’ collage. The author examines the music's unique recipe of phonographic juxtaposition, exploring the conditions of this ascribed ‘magic’, investigating gaps in perception between emotional and intellectual effect and deciphering parallels in the practice and vocabulary mobilised against a range of genres in performance magic.
OP14 The 2017 Health Technology Assessment International Asia Policy Forum: The Perspective Of Industry Members
Authors: Patel Parashar , Trowman Rebecca 
Published: January 2019

Introduction:The fifth Health Technology Assessment International (HTAi) Asia Policy Forum (APF) was held in Beijing, November 2017. The topic of the meeting was ‘Universal Health Care in the Asia Region: Overcoming the Barriers using HTA and Real World Data’. This presentation will focus on the use of real world data (RWD) as a mechanism of informing HTA in the Asia region – from the perspective of industry that were represented at the APF.Methods:The 2017 HTAi APF had senior representatives from 11 pharmaceutical and medical device companies active in the region. A keynote presentation was delivered that explored the findings of the background paper and survey, and there were guided breakout group discussions.Results:RWD is needed in all stages of the life cycle of a product; however, of greatest importance to industry is RWD to develop value propositions, inform HTA assessments, gauge market need and demonstrate where a new technology sits within an established clinical pathway. Although the HTA agencies present at the APF stated that RWD is available in the Asia region, this was not reflected by industry members who had limited awareness and access. Key concerns raised included whether this RWD is available for public use (and what caveats will be placed around its release), the quality of the data, whether it is longitudinal, and if it includes costs.Conclusions:There is a clear difference in the perspective of RWD between industry and HTA agencies in the Asia region. It is possible that this difference is driven by the apparent lack of publicly available data in the region and industry members comparing the use of RWD in Asia with the use in higher-income countries. This can be improved with clearer definitions, increased dialogue and multi-stakeholder collaboration in the region.
OP46 Redefining Mental Health Services For Youth: Evidence To Action
Authors: Ly Angela , Tremblay Gilbert A. , Beauchamp Sylvie 
Published: January 2019

Introduction:Current organization of mental health services in Canada imposes a rupture during youth transition to adulthood, when severe mental health disorders start appearing. This can have a major impact on youth recovery and social integration. A health technology assessment (HTA) was initiated to evaluate the efficacy of programs that simultaneously target adolescents and young adults to support decision making.Methods:A systematic review of systematic reviews was conducted. Four databases were searched (MEDLINE, Embase, Applied Social Sciences Index and Abstracts, and CINAHL) for articles published between 2000 and 2017. Article selection and quality assessment (ROBIS tool) were performed and inter-rater agreement was measured. To be included, the systematic review had to study specialized models or programs serving both adolescents and young adults. An analytical framework was constructed based on the categorization of performance measures for early intervention and the five dimensions of recovery. Group and individual interviews were conducted to collect contextual and experiential data.Results:A total of 1,054 references were identified. After applying the selection criteria, five systematic reviews were selected. The majority of programs identified were developed for early psychosis. This HTA did not identify specialized programs for other types of mental illness or at-risk youth. Evidence on early interventions for psychosis is emerging in regards to their efficacy in improving functional and clinical recovery. However, evidence has yet to be established for their impact on access. Contextual and experiential data from our organization validated and completed the scientific findings. Facilitating and constraining factors in the implementation of a person-centered care model and inter-agency collaboration were identified.Conclusions:Services targeting at-risk youth should be developed as part of a continuum of care that is adapted to clinical stages so that all youths living with psychological distress can be treated, regardless of diagnosis or age. These services may draw inspiration from models of early intervention for psychosis. Recommendations from this HTA are currently being put into action in the West Island of Montreal.