bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytotoxicity of three-dimensional paper-based models from a three-dimensional paper-based printer
Authors: Kozakiewicz Marcin , Szymor Piotr , Olszewski Raphael 
Published: September 2018

Objective: Our study aimed to determine the possibility of using models created with a low-cost, paper based 3D printer in an operating room. Therefore influence of different methods of sterilization on models was tested and cytotoxicity of generated models was determined. Material and methods: 30 cuboids divided into three groups were used for verification of shape stability after sterilization. Each group was sterilized either with: Ethylene oxide in temperature 55˚C, Hydrogen peroxide gas plasma in temperature 60˚C or Gamma irradiation at 21˚C, 25kGy. Each cuboid was measured using calliper three times before and three times after sterilization. Results were analysed statistically in Statgraphics Plus. Statistical significance was determined as p< 0.05. Sixty cylinders divided into six groups were used for cytotoxicity tests. Three of those groups were covered before sterilization with 2-octyl-cyanoacrylate. Each group was sterilized with one of the previously described methods. Cytotoxicity was tested by Nanostructural and Molecular Biophysics Laboratory in Technopark Lodz using normal adult human dermal fibroblasts. Survival of cells was tested using spectrophotometry with XTT and was defined as ratio of absorbency of tested probe to absorbency of control probe. Calcein/Ethidium dyeing test was performed according to LIVE/DEAD Viability/Cytotoxicity Kit protocol. Observation was done under Olympus GX71 fluorescence microscope. Results: There was no statistically significant difference for established statistical significance p=0.05 in cuboids dimensions before and after sterilization regardless of sterilization method. In XTT analysis all samples showed higher cytotoxicity against normal, human, adult dermal fibroblast culture when compared to positive control. ANOVA statistical analysis confirmed that 2-octyl cyanoacrylate coating of paper model improved biological behaviour of the material. It decreased cytotoxicity of the model independently of sterilization method. In calcein/ethidium dyeing test due to the high fluorescence of the background caused by cylinders of analysed substance it was impossible to perform the exact analysis of the number of marked cells. Conclusions: Acquired results allow to conclude that Mcor Technology Matrix 300 3D paper-based models can be used in operating room only if covered with cyanoacrylate tissue adhesive. Nemesis relevance: We found no statistically significant difference in cuboids dimensions before and after sterilization regardless of sterilization method. Three-dimensional paper-based models present with high cytotoxicity without coating.
New progress in understanding the cellular mechanisms of anti-arrhythmic drugs
Authors: An Zhe , Yang Guang , Liu Xuanxuan , Zhang Zhongfan , Liu Guohui 
Published: September 2018

AbstractAntiarrhythmic drugs are widely used, however, their efficacy is moderate and they can have serious side effects. Even if catheter ablation is effective for the treatment of atrial fibrillation and ventricular tachycardia, antiarrhythmic drugs are still important tools for the treatment of arrhythmia. Despite efforts, the development of antiarrhythmic drugs is still slow due to the limited understanding of the role of various ionic currents. This review summarizes the new targets and mechanisms of antiarrhythmic drugs.
Equiaxed Solidification of 430 Ferritic Stainless Steel Nucleating on Core-Containing Ti
Authors: Shi Xiaofang , Chang Lizhong 
Published: September 2018

AbstractThe solidification structure of ferritic stainless steel can be refined by controlling the contents of Ti, O, and N in the liquid steel through the thermodynamic analysis and high-temperature experiment. It is found by the scanning electron microscopy technology, in which the composite core of Ti nitride-enwrapping Ti oxide can be formed in the solidification front, which promotes the nucleation of δ iron and refines the solidification structure. Meanwhile, the structure analysis of the composite core by the transmission electron microscope technology proves that the Ti oxide that exists in the centre of the composite core is Ti2O3 and the Ti nitride that exists in the outer layer of the composite core is TiN.
Moisture Dependent Diffusion and Shrinkage in Yam during Drying
Authors: Amankwah Emmanuel A. , Dzisi Komla Agbeko , van Straten Gerrit , van Boxtel Anton J.B. 
Published: September 2018

Abstract
Crank’s analytical approximations for Fick’s diffusion equation were used to investigate the effect of moisture dependent sample thickness and diffusivity on the behavior of yam (Dioscoreaceae rotundata) cubicles during drying processes. Drying and shrinkage experiments were separately conducted at temperatures of 30, 40 and 50 °C in a cabinet drier. The comparative study of moisture dependent shrinkage and moisture dependent diffusivity justifies the interdependence of diffusivity and shrinkage due to water loss during drying. The behavior for yam is best explained by a combination of fractal moisture dependent shrinkage and moisture dependent diffusion, describing both the drying and rate curves better with good prediction of the high moisture regions. This assertion was reached as a result of low mean square error, standard error, percentage relative deviation, Akaike’s Information Criterion and high coefficient of determination. The results may indicate a varying mobility of water in food matrix of different moisture content in the multilayer and monolayer regimes.
Meta-analysis of PET/CT detect lymph nodes metastases of cervical cancer
Authors: Ruan Jianjiang , Zhang Yueqiao , Ren Hong 
Published: September 2018

Abstract

Objective
The aim of this study was to assess the diagnostic value of PET/CT for metastatic lymph nodes in cervical cancer patients.

Methods
Searching in the databases including PubMed, Embase, Web of Science, Cochrane Library and Google Scholar about non-invasive modalities for detecting lymph nodes metastases during 2000~2017. Following further screening, the extracted effective data were calculated by Meta-Disc 1.4 software, such as sensitivity (SEN), specificity (SPE), positive likelihood (LR+), and negative likelihood ratio (LR-).

Results
we obtained 27 articles. The pooled estimates for sensitivity of PET/CT were 0.72 (95% CI, [0.69, 0.75]); for specificity were 0.96 (95% CI, [0.96, 0.97]). Its weighted AUC was 0.93.

Conclusion
PET/CT remains to be an effective method for diagnosis of metastatic lymph nodes from cervical cancer.
Roman Republican coins in the collection of the Palacký University in Olomouc
Authors: Militký Jiří 
Published: September 2018

Abstract
The collection of ancient coins of the Palacký University in Olomouc is recently preserved in the department of history there. It is very likely that the collection was founded sometimes between the second half of the 19th century and the beginning of the 20th century – no details are known about it and the collection became the university property evidently after 1946. The core of the Olomouc collection is represented by denarii dating back to 154–74 BC (cat. nos. 3–69). Only individual pieces of the earlier issues (cat. nos. 1–2) and the later issues (cat. nos. 70–72) are present here. Publication of this collection could be accepted as a small contribution to documentation of the physically verified material of the mentioned period. Parallelly, it is an interesting testimony of the collecting activities in Olomouc at the break of the 19th and 20th centuries.
Hoard of Bohemian and Meissen bracteates found in Natternberg (local part of Deggendorf, Lower Bavaria)
Authors: Hylla Alexandra , Schneider Petr 
Published: September 2018

Abstract
Around 1950, during the forestry works near Natternberg (local part of Deggendorf, Lower Bavaria), some 26 bracteates were found. Only in 2012, the grandson of the finder reported the hoard and passed it for documentation to the Staatliche Münzsammlung München. Later on, the coins were returned to the owner and then sold in the numismatic auction. The Bohemian part is represented by three large bracteates struck under King Ottokar I of Bohemia (1192–1193, 1197–1230) during the last decade of his rule (cat. nos. 1–3). The Meissen coins are represented by 23 large bracteates struck (cat. nos. 4–26) under Margrave Henry III the Illustrious (1221/1230–1288) during the first decade of his rule. The hoard was buried in Natternberg very likely sometimes around 1230. Appearance of the Bohemian and Meissen bracteates is quite rare in Lower Bavaria, the twosided pfennigs from Regensburg and Passau circulated there predominantly. But it is still possible to think about their transfer from Bohemia, most likely from the Sušice surroundings, which was, as a possession of the Bavarian Counts of Bogen at that time (from the 12th century until 1242), connected through Gunther’s path with Deggendorf surroundings. The hoard could represent a separated part of a larger cash of a tradesman, which was possibly intended for hiding because of the forced exchange in the local markets.
The schizophrenia oral health profile: Development and feasibility
Authors: Frederic Denis , Corinne Rat , Matthieu Reynaud , Francesca Siu-Paredes , Stephanie Tubert-Jeannin , Nathalie Rude 
Published: September 2018

Abstract

Background
The aim of this study was to present the different stages of development of the Schizophrenia Oral Health Profile (SOHP) questionnaire, aimed at assessing oral disorders and their impacts on functioning and psychosocial wellbeing for patients with schizophrenia (PWS) and to give the results of a feasibility study conducted in France

Materials and methods
The first step of this qualitative study was semi-structured interviews were conducted with 20 PWS and 6 health professionals (HP). A focus group integrating 4 PWS and 4 HP was also organised to identify the items of the SOHP. The data were analysed using a thematic analysis. Second, a feasibility study was conducted in a sample of 30 PWS who answered the SOHP questionnaire. The acceptability and understanding of the SOHP were evaluated, using a specific questionnaire.

Results
The semi-structured interviews and focus groups included 34 individuals in total. Items’ selection was done with several stages and led to a SOHP scale with 53 final items related to oral disorders and their impacts on functioning and psychosocial well-being. These items were classified in 13 preselected dimensions including one additional module related to the side effects of medications (11 items). The feasibility study showed good acceptability and understanding of the items of the SOHP scale.

Conclusions
The psychometric validation of the SOHP scale, involving a large sample of PWS, is currently in progress. The SOHP is important to evaluate PWS oral health needs and to offer appropriate strategies to improve oral health of this persons.

Trial registration
Clinical Trials Gov NCT02730832. Date registered: 21 March, 2016.
Unusual high blood glucose in ketoacidosis as first presentation of type 1 diabetes mellitus
Authors: Hörber Sebastian , Hudak Sarah , Kächele Martin , Overkamp Dietrich , Fritsche Andreas , Häring Hans-Ulrich , Peter Andreas , Heni Martin 
Published: September 2018

Summary
Diabetic ketoacidosis is a life-threatening complication of diabetes mellitus. It usually occurs in patients with type 1 diabetes where it is typically associated with only moderately increased blood glucose. Here, we report the case of a 52-year-old female patient who was admitted to the emergency unit with severely altered mental status but stable vital signs. Laboratory results on admission revealed very high blood glucose (1687 mg/dL/93.6 mmol/L) and severe acidosis (pH <7) with proof of ketone bodies in serum and urine. Past history revealed a paranoid schizophrenia diagnosed 10 years ago and for which the patient was treated with risperidone for many years. Acute treatment with intravenous fluids, intravenous insulin infusion and sodium bicarbonate improved the symptoms. Further laboratory investigations confirmed diagnosis of autoimmune type 1 diabetes. After normalization of blood glucose levels, the patient could soon be discharged with a subcutaneous insulin therapy.

Learning points:

Diabetic ketoacidosis as first manifestation of type 1 diabetes can occur with markedly elevated blood glucose concentrations in elder patients.

Atypical antipsychotics are associated with hyperglycemia and an increased risk of new-onset diabetes.

First report of risperidone-associated diabetic ketoacidosis in new-onset type 1 diabetes.

Patients treated with atypical antipsychotics require special care and regular laboratory examinations to detect hyperglycemia and diabetic ketoacidosis.

In cases when the diagnosis is in doubt, blood gas analysis as well as determination of C-peptide and islet autoantibodies can help to establish the definite diabetes type.
Analiza rynku nieruchomości jako element diagnozy sfery gospodarczej w programach rewitalizacji w Polsce
Authors: Jadach-Sepioło Aleksandra 
Published: September 2018

The real estate market is rarely analysed as a component of economic assessments during the preparation of urban regeneration programs, though low real estate prices and their limited liquidity are often main reasons for a degraded area’s lack of attractiveness. The potential increase in the value of real estate may also be one of the basic motivators to engage in property revitalisation activities.The article presents the potential of the real estate market analyses in the context of delimiting degraded areas in urban regeneration programs and the attendant study of the economy.
Warunki i decyzje mieszkaniowe seniorów na lokalnym rynku nieruchomości
Authors: Strączkowski Łukasz , Boruta Marcin 
Published: September 2018

According to experts, continuous population aging will bring about numerous changes on the housing market. There is widening discussion on the provision of adequate care for the elderly, matching housing to seniors’ preferences and expectations, and decisions related to the prospective changes of their housing conditions and the choice of a new home. The paper contributes to the debate, showing the housing situation of older people. In order to achieve the aim, a questionnaire survey was conducted among senior citizens examining their housing situation.The research findings show that seniors want to age in place as long as possible with the assistance of formal or informal helpers. Moreover, younger groups of seniors tend to be more open to living in senior housing estates as well as for co-housing in exchange for help. Seniors that live independently would rather move into a nursing home, either private or public.
Zastosowanie taksonomii do aktualizacji wartości zabezpieczenia hipotecznego nieruchomości mieszkaniowych w bankach na przykładzie Wrocławia
Authors: Bywalec Magdalena , Makowska Anita 
Published: September 2018

The Polish Financial Supervision Authority̛s regulations on credit risk management in bank portfolios require banks to update the value of real estate that provides collateral for mortgages. Using statistical analysis to determine the value of real estate on the Polish market, scientists and market practitioners are working on other methods of determining the value of real estate, as specified in the Regulation of the Council of Ministers of 21 September 2004 on the Real Estate Valuation and Appraisal Report.The paper explains the uses and consequences of taxonomy to update the value of mortgage collateral in banks. It presents a comparison of a traditional real estate valuation method, paired comparison, with the effects of the valuation of the taxonomic method pattern. As a result of updating the value of residential property portfolios held by banks, done at the end of 2016, there were 50 valuations corrected in minus and 47 in plus. Updating the value of the real estate portfolio using based on taxonomic analysis indicated 29 corrections in minus and 68 corrections in plus in variant I and 32 in minus and 65 in plus in variant II. There was a noticeable increase in value, which results in a higher value of the portfolio, which in variant I reached PLN 33 742 098.85 in variant II PLN 33 754 650.85. In both variants, the value of the real estate portfolio increased after the pattern update.
Odpowiedzialność odszkodowawcza państwa z tytułu rozwoju infrastruktury drogowej
Authors: Tomecki Marcin 
Published: September 2018

Developing the road infrastructure is expensive, with the costs including not only for construction and maintenance but also the payment of compensation for damages. The main aim of this research is to identify the investorʼs scope of responsibility for the development of the road infrastructure and its impact on cost growth. The subject of research is the responsibility the State Treasury bears for developing infrastructure in selected road investments. An analysis of legal regulations governing the State Treasury’s liability and judicial decisions in this area has been conducted. The results of research lead to several conclusions. The responsibility of the State Treasury for expropriating road construction is limited and does not include lost benefits. The most common reason damages are paid by the investor is damage caused by noise and vibration. Claims are more effectively recovered if the property is located in a Restricted Use Zone. The scope of responsibility for noise and vibrations include damages on personality rights too.
Ceny ziemi rolnej w Polsce na tle Unii Europejskiej
Authors: Firlej Krzysztof , Kubala Sebastian 
Published: September 2018

Long before Poland̛s accession to the European Union, the prices of agricultural land were of interest not only to potential investors in the agri-food sector, but also to speculators, whom agroeconomists were tasked with monitoring. The aim of this study was to assess changes in agricultural land prices in Poland compared to the European Union and to identify variables that strongly depend on the average level of prices of agricultural land in the European Union. This article also demonstrates that in EU countries there is a significant correlation between agricultural land prices and the value of direct payments and the value of gross domestic product per capita.
Response to Oral Immediate-Release Opioids for Breakthrough Pain in Patients with Advanced Cancer with Adequately Controlled Background Pain
Authors: Azhar Ahsan , Kim Yu Jung , Haider Ali , Hui David , Balankari Vishidha R. , Epner Margeaux Chiou , Park Minjeong , Liu Diane D. , Williams Janet , Frisbee-Hume Susan E. , Allo Julio A. , Bruera Eduardo 
Published: September 2018

Abstract

Background
There is limited evidence about the response of breakthrough pain (BTP) to the most commonly used oral immediate-release (IR) opioids. Our aim was to determine response rate to oral IR opioids for BTP control in patients with advanced cancer.

Materials and Methods
In this prospective study, palliative care outpatients, with advanced cancer and adequately managed background pain, were asked to complete a self-administered survey. We assessed patients’ baseline demographics, pain characteristics, alcoholism (CAGE questionnaire), tobacco and substance abuse, and Edmonton Symptom Assessment Scores (ESAS). We determined the effectiveness of oral IR BTP opioids by using a 7-point Likert scale ranging from “very ineffective” to “very effective.” “Effective” and “very effective” were defined a priori as a good response to IR opioids for BTP.

Results
Of 592 evaluable patients, 192 (32%) had background pain of ≤3 (ESAS pain scale 0–10). Among these 192 patients, 152 (79%) reported BTP, 143/152 (94%) took oral IR opioids for BTP, and 127/143 (89%) responded to a median dose of 10% of the total morphine equivalent daily dose. In univariate logistic regression analysis, younger age (odds ratio [OR], 0.94 per year; p = .008), higher ESAS scores for pain (OR, 1.32; p = .012), anxiety (OR, 1.24; p = .017), and dyspnea (OR, 1.31; p = .007) had statistically significant association with poor response to IR opioids for BTP. In multicovariate logistic regression, adjusted for age, a higher ESAS dyspnea score was significantly associated with poor response to oral IR opioids (OR, 1.44; p = .002).

Conclusion
The vast majority of patients with advanced cancer with adequately controlled background pain reported a good response to oral IR opioids for BTP, supporting their use in clinical practice.

Implications for Practice
Oral immediate-release opioids are standard treatment for cancer breakthrough pain. However, information regarding treatment response to these commonly used opioids is limited. This study provides information that the vast majority of patients with advanced cancer, with adequately controlled background pain, reported good response to oral immediate release opioids for managing their breakthrough pain episodes. Results of this study support the use of conventional oral immediate release opioids that are relatively inexpensive and readily available for management of breakthrough pain in patients with advanced cancer.
A Phase II Trial of Pazopanib in Patients with Metastatic Alveolar Soft Part Sarcoma
Authors: Kim Miso , Kim Tae Min , Keam Bhumsuk , Kim Yu Jung , Paeng Jin Chul , Moon Kyung Chul , Kim Dong-Wan , Heo Dae Seog 
Published: September 2018

Abstract

Lessons Learned
Pazopanib shows a modest efficacy in metastatic alveolar soft part sarcoma. Clinical outcomes were comparable to those in previous studies using antiangiogenic drugs. Further prospective studies evaluating the benefit of pazopanib in alveolar soft part sarcoma with a larger sample are warranted to validate results.

Background
Alveolar soft part sarcoma (ASPS) is a rare mesenchymal malignant tumor characterized by an unbalanced translocation, t(X;17)(p11.2;q25), which leads to the fusion of ASPSCR1 to the TFE3 transcription factor. Because this results in the upregulation of angiogenesis-related transcripts, antiangiogenic drugs have been used in ASPS patients.

Methods
This open-label, single-arm, multicenter, investigator-initiated phase II trial was designed to evaluate efficacy and safety of pazopanib 800 mg once daily in patients with metastatic ASPS. The primary endpoint was investigator-assessed overall response rate (ORR), and secondary endpoints were toxicity, progression-free survival (PFS), and overall survival (OS). 68Ga-RGD (Arg-Gly-Asp) positron emission tomography (PET) scan and gene expression profiling using NanoString platform were performed for biomarker analysis.

Results
Six patients with histologically confirmed metastatic ASPS were enrolled between December 2013 and November 2014. Among six patients, one achieved a partial response (PR) (ORR 16.7%) and five patients showed stable disease (SD). With a median follow-up of 33 months (range 18.7–39.3 months), median PFS was 5.5 months (95% confidence interval [CI] 3.4–7.6 months), and median OS was not reached. There were no severe toxicities except one patient with grade 3 diarrhea.

Conclusion
Pazopanib showed modest antitumor activity with manageable toxicities for patients with metastatic ASPS.