bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-dimensional computational model simulating the fracture healing process with both biphasic poroelastic finite element analysis and fuzzy logic control
Authors: Wang Monan , Yang Ning 
Published: April 2018

AbstractA dynamic model regulated by both biphasic poroelastic finite element analysis and fuzzy logic control was established. Fuzzy logic control was an easy and comprehensive way to simulate the tissue differentiation process, and it is convenient for researchers and medical experts to communicate with one another to change the fuzzy logic rules and improve the simulation of the tissue differentiation process. In this study, a three-dimensional fracture healing model with two different interfragmentary movements (case A: 0.25 mm and case B: 1.25 mm) was analysed with the new set-up computational model. As the healing process proceeded, both simulated interfragmentary movements predicted a decrease and the time that the decrease started for case B was later than that for case A. Compared with experimental results, both cases corresponded with experimental data well. The newly established dynamic model can simulate the healing process under different mechanical environments and has the potential to extend to the multiscale healing model, which is essential for reducing the animal experiments and helping to characterise the complex dynamic interaction between tissue differentiations within the callus region.
New detections of (sub)millimeter hydrogen radio recombination lines towards high-mass star-forming clumps
Authors: Kim W.-J. , Urquhart J. S. , Wyrowski F. , Menten K. M. , Csengeri T. 
Published: April 2018

Aims. Previous radio recombination line (RRL) observations of dust clumps identified in the APEX Telescope Large Area Survey of the Galaxy (ATLASGAL) have led to the detection of a large number of RRLs in the 3 mm range. Here, we aim to study their excitation with shorter wavelength (sub)millimeter radio recombination line (submm-RRL) observations.
Methods. We made observations of submm-RRLs with low principal quantum numbers (n ≤ 30) using the APEX 12 m telescope, toward 104 H II regions associated with massive dust clumps from ATLASGAL. The observations covered the H25α, H28α, and H35β transitions. Toward a small subsample the H26α, H27α, H29α, and H30α lines were observed to avoid contamination by molecular lines at adjacent frequencies.
Results. We have detected submm-RRLs (signal-to-noise (S∕N)≥ 3 σ) from compact H II regions embedded within 93 clumps. The submm-RRLs are approximately a factor of two brighter than the mm-RRLs and consistent with optically thin emission in local thermodynamic equilibrium (LTE). The average ratio (0.31) of the measured H35β/H28α fluxes is close to the LTE value of 0.28. No indication of RRL maser emission has been found. The Lyman photon flux, bolometric, and submm-RRL luminosities toward the submm-RRL detected sources present significant correlations. The trends of dust temperature and the ratio of bolometric luminosity to clump mass, Lbol ∕Mclump, indicate that the H II regions are related to the most massive and luminous clumps. By estimating the production rate of ionizing photons, Q, from the submm-RRL flux, we find that the Q(H28α) measurements provide estimates of the Lyman continuum photon flux consistent with those determined from 5 GHz radio continuum emission. Six RRL sources show line profiles that are a combination of a narrow and a broad Gaussian feature. The broad features are likely associated with high-velocity ionized flows.
Conclusions. We have detected submm-RRLs toward 93 ATLASGAL clumps. Six RRL sources have high-velocity RRL components likely driven by high-velocity ionized flows. Their observed properties are consistent with thermal emission that correlates well with the Lyman continuum flux of the H II regions. The sample of H II regions with mm/submm-RRL detections probes, in our Galaxy, luminous clumps (Lbol > 104 L⊙) with high Lbol∕Mclump. We also provide suitable candidates for further studies of the morphology and kinematics of embedded, compact H II regions with the Atacama Large Millimeter/submillimeter Array (ALMA).
Phase behaviors of deeply supercooled bilayer water unseen in bulk water
Authors: Kaneko Toshihiro , Bai Jaeil , Akimoto Takuma , Francisco Joseph S. , Yasuoka Kenji , Zeng Xiao Cheng 
Published: April 2018

Significance
Bulk water exhibits rich phase behavior with numerous crystalline and amorphous ice phases. Although a recent femtosecond X-ray scattering experiment provides the first evidence of two forms of liquid water in deeply supercooled droplets, coexistence of the two forms of liquid water is still short-lived due to the known “no-man’s land” issue for bulk water. Here, we demonstrate simulation evidence that, in an isolated nanoslit, two forms of 2D liquid water, namely, the bilayer very low density liquid and bilayer high-density liquid, can arise in deeply supercooled states, but separated by the solid phase of bilayer amorphous ice whose melting line exhibits the isochore end point. A hitherto unreported bilayer very low density amorphous ice, largely in the negative pressure region, is also revealed.
BNPMDA: Bipartite Network Projection for MiRNA–Disease Association prediction
Authors: Chen Xing , Xie Di , Wang Lei , Zhao Qi , You Zhu-Hong , Liu Hongsheng 
Published: April 2018

Abstract

Motivation
A large number of resources have been devoted to exploring the associations between microRNAs (miRNAs) and diseases in the recent years. However, the experimental methods are expensive and time-consuming. Therefore, the computational methods to predict potential miRNA–disease associations have been paid increasing attention.

Results
In this paper, we proposed a novel computational model of Bipartite Network Projection for MiRNA–Disease Association prediction (BNPMDA) based on the known miRNA–disease associations, integrated miRNA similarity and integrated disease similarity. We firstly described the preference degree of a miRNA for its related disease and the preference degree of a disease for its related miRNA with the bias ratings. We constructed bias ratings for miRNAs and diseases by using agglomerative hierarchical clustering according to the three types of networks. Then, we implemented the bipartite network recommendation algorithm to predict the potential miRNA–disease associations by assigning transfer weights to resource allocation links between miRNAs and diseases based on the bias ratings. BNPMDA had been shown to improve the prediction accuracy in comparison with previous models according to the area under the receiver operating characteristics (ROC) curve (AUC) results of three typical cross validations. As a result, the AUCs of Global LOOCV, Local LOOCV and 5-fold cross validation obtained by implementing BNPMDA were 0.9028, 0.8380 and 0.8980 ± 0.0013, respectively. We further implemented two types of case studies on several important human complex diseases to confirm the effectiveness of BNPMDA. In conclusion, BNPMDA could effectively predict the potential miRNA–disease associations at a high accuracy level.

Availability and implementation
BNPMDA is available via http://www.escience.cn/system/file?fileId=99559.

Supplementary information
Supplementary data are available at Bioinformatics online.
Malaria and the Microbiome: A Systematic Review
Authors: Ippolito Matthew M , Denny Joshua E , Langelier Charles , Sears Cynthia L , Schmidt Nathan W 
Published: April 2018

Abstract

Background
The microbiome influences malaria parasite fitness and transmission efficiency in mosquitoes and appears to affect malaria dynamics in mammalian hosts as well. Nascent research examining the interrelationship of malaria and the mammalian microbiome has yielded interesting insights inviting further study.

Methods
We conducted a systematic review of the literature examining associations between the microbiome and malaria in mammalian hosts. An electronic search algorithm was adapted to PubMed, MEDLINE, Scopus, Embase, and Web of Science, and reference lists of relevant sources were manually searched. Identified studies were screened and assessed independently by 2 authors, and results were compiled in a qualitative synthesis of the evidence.

Results
Ten relevant studies were identified. They demonstrate associations between certain intestinal communities and protection against Plasmodium infection and modulation of disease severity. Plasmodium infection acutely and reversibly reshapes gut microbial composition in mice. The makeup of human skin microbial communities may influence mosquito attraction and thus disease transmission.

Conclusions
Early research supports a relationship between malaria and the microbiome. The evidence is incomplete, but the observed associations are evocative and signal a promising avenue of inquiry. Microbiome-based studies of malaria can be readily integrated into field-based research.
Exploring Older Adults’ Video Game Use in the PRISM Computer System
Authors: Boot Walter R , Moxley Jerad H , Roque Nelson A , Andringa Ronald , Charness Neil , Czaja Sara J , Sharit Joseph , Mitzner Tracy , Lee Chin Chin , Rogers Wendy A 
Published: April 2018

Abstract

Background and Objective
As part of the PRISM (Personal Reminder Information & Social Management) randomized field trial, a large group of older adults (N = 150) received a computer system in their home that presented them with the opportunity to play eleven different video games. While researchers have often assessed older adults’ gaming preferences and habits through survey data and focus groups, this trial represented a unique opportunity to study gaming behavior “in the wild” over an entire year.

Research Design and Methods
We present an exploration of game usage data, individual differences in game preferences and gaming habits, and individual difference predictors of game use.

Results
Although few individual difference variables consistently predicted game use and preferences, there were clear favorites among the different games, and results demonstrate that given the opportunity and training many older adults may become active and long-term gamers.

Discussion and Implications
Findings have implications for designing video games that older adults enjoy, supporting enjoyable and meaningful interactions with video games across the life span, and for designing cognitive, social, and health interventions involving games.
When Bodies Meet: Fraught Companionship and Entangled Embodiment in Jeremiah 36
Authors: Graybill Rhiannon 
Published: April 2018

AbstractThis paper uses Donna Haraway’s theoretical work on “companion species” to offer a new perspective on the mutually implicated bodies in chapter 36 of the biblical book of Jeremiah. Jeremiah 36 narrates the prophet’s dictation of a scroll to his scribe, Baruch; the scroll is subsequently read aloud, destroyed, and recreated. Though the story is filled with prophets, scribes, secretaries, and a furious king, it is fundamentally the story of a scroll, and of a scroll as body. This paper treats the scroll-body as companion species, foregrounding relations of entanglement and significant otherness. Haraway’s theorization of interdependence, conflict, and co-becoming offers a new model for understanding the individual and compounded bodies of prophet, scribe, king, and nation. The paper experiments in (fraught) companionship and mutual embodiment, offering an alternate framework for imagining the body in and of prophecy. This reading opens new ways of thinking across bodies, texts, and traditions.
Intratumoral heterogeneity of oxygen metabolism and neovascularization uncovers 2 survival-relevant subgroups of IDH1 wild-type glioblastoma
Authors: Stadlbauer Andreas , Zimmermann Max , Doerfler Arnd , Oberndorfer Stefan , Buchfelder Michael , Coras Roland , Kitzwögerer Melitta , Roessler Karl 
Published: April 2018

Abstract

Background
The intratumoral heterogeneity of oxygen metabolism in combination with variable patterns of neovascularization (NV) as well as reprogramming of energy metabolism affects the landscape of tumor microenvironments (TMEs) in glioblastoma. Knowledge of the hypoxic and perivascular niches within the TME is essential for understanding treatment failure.

Methods
Fifty-two patients with untreated glioblastoma (isocitrate dehydrogenase 1 wild type [IDH1wt]) were examined with a physiological MRI protocol including a multiparametric quantitative blood oxygen level dependent (qBOLD) approach and vascular architecture mapping (VAM). Imaging biomarker information about oxygen metabolism (mitochondrial oxygen tension) and neovascularization (microvascular density and type) were fused for classification of 6 different TMEs: necrosis, hypoxia with/without neovascularization, oxidative phosphorylation (OxPhos), and glycolysis with/without neovascularization. Association of the different TME volume fractions with progression-free survival (PFS) was assessed using Kaplan–Meier analysis and Cox proportional hazards models.

Results
A common spatial structure of TMEs was detected: central necrosis surrounded by tumor hypoxia (with defective and functional neovasculature) and different TMEs with a predominance of OxPhos and glycolysis for energy production, respectively. The percentage of the different TMEs on the total tumor volume uncovered 2 clearly different subtypes of glioblastoma IDH1wt: a glycolytic dominated phenotype with predominantly functional neovasculature and a necrotic/hypoxic dominated phenotype with approximately 50% of defective neovasculature. Patients with a necrotic/hypoxic dominated phenotype showed significantly shorter PFS (P = 0.035).

Conclusions
Our non-invasive mapping approach allows for classification of the TME and detection of tumor-supportive niches in glioblastoma which may be helpful for both clinical patient management and research.
A Systematic Review of the Processes Underlying the Main and the Buffering Effect of Social Support on the Experience of Pain
Authors: Che Xianwei , Cash Robin , Ng Sin Ki , Fitzgerald Paul , Fitzgibbon Bernadette M. 
Published: April 2018

Objective:
This review aimed to explore the processes that underlie the main and the buffering effect of social support on decreased pain experience.

Materials and Methods:
The systematic review was conducted according to the PRISMA guidelines. Online databases of PubMed and PsycINFO were searched for peer-reviewed articles using keywords (“social support,” OR “interpersonal,” OR “social presence,” OR “spouse,” OR “couple,” OR “marriage”) AND “pain”). Articles were included if they examined the cognitive or behavioral processes linking social support to any aspects of reduced pain experience.

Results:
The database search identified 38 studies, of which 33 were cognitive-behavioral studies and 5 were neurobiological. Cognitive-behavioral studies generated a total of 57 findings of the analgesic influence of social support. This effect was further categorized as social support decreasing the adverse influence of pain-related stress (28/44 findings), reappraising pain-related stress (7/9 findings), and facilitating coping attempts (2/4 findings). Of the 5 neurobiological studies, the influence of social support on pain reduction was associated with reduced neural and physiological stress systems in response to painful stimuli.

Discussion:
This review presents evidence that the stress-buffering effect is more often able to account for the relationship between social support and pain experience. Moreover, findings suggest the critical significance of stress appraisal and attenuated stress systems in linking social support to aspects of reduced pain experience. Findings implicate the role of integrating perceived support and intimacy in support-oriented interventional trials for chronic pain.
Perioperative Complications After Surgery for Thoracic Ossification of Posterior Longitudinal Ligament
Authors: Imagama Shiro , Ando Kei , Takeuchi Kazuhiro , Kato Satoshi , Murakami Hideki , Aizawa Toshimi , Ozawa Hiroshi , Hasegawa Tomohiko , Matsuyama Yukihiro , Koda Masao , Yamazaki Masashi , Chikuda Hirotaka , Shindo Shigeo , Nakagawa Yukihiro , Kimura Atsushi , Takeshita Katsushi , Wada Kanichiro , Katoh Hiroyuki , Watanabe Masahiko , Yamada Kei , Furuya Takeo , Tsuji Takashi , Fujibayashi Shunsuke , Mori Kanji , Kawaguchi Yoshiharu , Watanabe Kota , Matsumoto Morio , Yoshii Toshitaka , Okawa Atsushi 
Published: April 2018

Study Design.
Prospective, multicenter, nationwide study.

Objective.
To investigate perioperative complications and risk factors in surgery for thoracic ossification of the posterior longitudinal ligament (T-OPLL) using data from the registry of the Japanese Multicenter Research Organization for Ossification of the Spinal Ligament.

Summary of Background Data.
There is no prospective multicenter study of surgical complications and risk factors for T-OPLL, and previous multicenter retrospective studies have lacked details.

Methods.
Surgical methods, preoperative radiographic findings, pre- and postoperative thoracic myelopathy (Japanese Orthopaedic Association [JOA] score), prone and supine position test (PST), intraoperative ultrasonography, and intraoperative neurophysiological monitoring (IONM) were investigated prospectively in 115 cases (males: 55, females: 60, average age 53.1 y). Factors related to perioperative complications and risk factors for postoperative motor palsy were identified.

Results.
Posterior decompression and fusion with instrumentation with or without dekyphosis was performed in 85 cases (74%). The JOA recovery rate at 1 year after surgery in all cases was 55%. Motor palsy occurred postoperatively in 37 cases (32.2%), with a mean recovery period of 2.7 months. A long recovery period for postoperative motor palsy was significantly associated with a high number of T-OPLL levels (P < 0.0001), lower preoperative JOA score (P < 0.05), and greater estimated blood loss (P < 0.05). Perioperative complications or postoperative motor palsy were significantly related to a higher number of T-OPLL levels, comorbid ossification of ligamentum flavum rate, lower preoperative JOA score, higher preoperative positive PST rate, more surgical invasiveness, a lower rate of intraoperative spinal cord floating in ultrasonography, and higher rate of deterioration of IONM.

Conclusion.
This study firstly demonstrated the perioperative complications with high postoperative motor palsy rate in a nationwide multicenter prospective study. Surgical outcomes for T-OPLL should be improved by identifying and preventing perioperative complications with significant risk factors.

Level of Evidence: 3
Keratoacanthomatous Changes: Unifying the Histologic Spectrum of Actinic Granuloma
Authors: Harb Jennifer N. , Kalen Jessica E. , Hsu Sylvia , Diwan Abdul Hafeez , Calame Antoanella , Motaparthi Kiran 
Published: April 2018

Abstract:
Actinic granuloma (AG) manifests as annular plaques on sun-damaged skin. There remains no universal consensus on the nosology, etiology, or clinicopathologic criteria of AG as a distinct entity. Broadly, AG is characterized by granulomatous inflammation, multinucleated giant cells, elastophagocytosis, and the absence of mucin and necrobiosis. It is not uncommon, however, to encounter overlapping histological features of other granulomas, such as granuloma annulare and necrobiosis lipoidica, confounding the diagnosis of this controversial entity. Herein, we describe 2 cases of AG with features of granuloma annulare and necrobiosis lipoidica, supporting the concept of AG as a histologic spectrum. These 2 cases displayed dilated follicular infundibula and pseudoepitheliomatous hyperplasia analogous to changes in keratoacanthomas. These unique epithelial changes, in tandem with characteristic elastin alterations and clinical findings, are helpful and unifying features that permit accurate diagnosis of this controversial entity.
Tilianin-loaded Reactive Oxygen Species-Scavenging Nano-Micelles Protect H9c2 Cardiomyocyte Against Hypoxia/Reoxygenation-Induced Injury
Authors: Wang Yanfang , Wang Ying , Wang Xinchun , Hu Ping 
Published: April 2018

Abstract:
Previous studies have shown that tilianin alleviates ischemia-reperfusion-induced cardiomyocyte injury. However, its clinical translation has been hampered because of its insolubility in water. Tilianin-based nano-micelles that may overcome this critical issue are presented. A polyethylene glycol compound was covalently attached to propylene sulfide-formed amphiphilic diblock polymers. In the aqueous solution, tilianin is encapsulated in a hydrophobic shell to form nano-micelles. The Ph-PPS-PEG self-assembled into nanoscale micelles with a size of approximately 70 nm, termed “tilianin-loaded micelles” (TLMs). TLMs are highly efficient hydrogen peroxide scavengers and the activity of caspase-3 inhibition, thereby protecting cells from H/R-induced cytotoxicity. In addition, TLMs decreased levels of MDA, IL-1 and tumor necrosis factor (TNF-α), inhibited apoptosis, TLR4 and nuclear transcription factor (NF-κB p65) protein expression in hypoxia-reoxygenation (H/R) model. Taken together, the study suggests that TLMs may be of clinical value for the protective effects of cardiomyocytes by inhibiting Inflammation and oxidative stress during myocardial ischemia-reperfusion injury.
Patients with chronic pain exhibit a complex relationship triad between pain, resilience, and within- and cross-network functional connectivity of the default mode network
Authors: Hemington Kasey S. , Rogachov Anton , Cheng Joshua C. , Bosma Rachael L. , Kim Junseok Andrew , Osborne Natalie R. , Inman Robert D. , Davis Karen D. 
Published: April 2018

Abstract
Resilience is a psychological trait that strongly predicts chronic pain–related health outcomes. The neural correlates of both pain and trait resilience are critical to understand the brain–behaviour relationship in chronic pain; yet, neural correlates of resilience in chronic pain states are unknown. However, measures of pain perception and a wide range of psychological health measures have been linked to function of the default mode network (DMN). Thus, we aimed to determine the relationships between resilience, pain perception, and functional connectivity (FC) within the DMN and between the DMN and other brain networks. Resting-state functional magnetic resonance imaging data were acquired from 51 chronic pain patients with a form of spondylarthritis (ankylosing spondylitis) and 51 healthy control participants. Participants completed a questionnaire on their individual trait resilience (the Resilience Scale), and patients reported their clinical pain. In healthy controls, we found within-DMN FC to be stronger in less resilient individuals. In patients with chronic pain, individual resilience was negatively correlated with pain and disease activity. Cross-network FC between the DMN and the sensorimotor network was abnormally high in patients with high clinical pain scores on the day of the study. Finally, there was an interaction between within-DMN FC and clinical pain report in patients: In patients reporting greater pain, the relationship between within-DMN connectivity and resilience was atypical. Thus, our findings reveal different neural representations of resilience and pain. The way in which these behavioural measures interact provides insight into understanding the neural correlates of chronic pain.