bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct oral anticoagulants: first airbag
Authors: Sokolova A. N. , Skripka A. I. 
Published: April 2019

The safety profile of oral anticoagulants (DOACs) was confirmed in the large-scale studies, the increased risk of hemorrhagic events does still exist, which may be caused by the nature of the patient’s concomitant pathology, the resulting injury or the need for emergency surgical procedures. Such measures to restore the coagulation cascade as the use of prothrombin complex concentrates or hemodialysis have not been widely used in the clinical practice to stop the anti-coagulant effect of DOACs and do not have an evidence base. Today, idarutsizumab (Praxbind) is the only specific antagonist to DOACs registered in the Russian Federation, a neutralizing agent that interacts with free and thrombin-related dabigatran, without affecting other blood coagulation factors and platelet function. RE-VERSE AD study showed that administration of idarucizumab in patients receiving dabigatran therapy and who developed life-threatening bleeding provided complete neutralization of the anti-coagulant effect of dabigatran for 4 hours, and after 1.5 hours emergency surgical treatment was performed, achieving at the same time, normal perioperative hemostasis in 93.4% of cases. The availability of a specific neutralizing agent for a specific DOAC could be identified as arguments in favour of choosing this drug for patients who have a high risk of a hemorrhagic event, emergency surgery or thrombolysis.
Magnesium and female reproductive system
Authors: Nazarenko E. G. 
Published: April 2019

The article emphasizes the role of magnesium in a woman’s body, the causes and symptoms of its deficiency. It also describes the role of estrogens, combined oral contraceptives and hormone replacement therapy in the development of magnesium-deficient states, and the relationship between these states and vitamin B6. The paper overviews multicenter studies on the treatment of magnesiumdeficient conditions from the standpoint of evidence-based medicine, which show the need to maintain an adequate level of magnesium and pyridoxine in the treatment of estrogen-dependent diseases.
Effects of Resveratrol, Berberine and Their Combinations on Reactive Oxygen Species, Survival and Apoptosis in Human Squamous Carcinoma (SCC-25) Cells
Authors: Skonieczna Magdalena , Hudy Dorota , Poterala-Hejmo Aleksandra , Hejmo Tomasz , Buldak Rafal J. , Dziedzic Arkadiusz 
Published: April 2019

Background:
Levels of cellular Reactive Oxygen Species (ROS) influence the oxidized/reduced
states of cellular proteins, and create redox-signaling pathways that can activate transcription factors, kinases,
and phosphatases. ROS levels can be increased radically by external factors, including ionizing and UV radiation or
exposure to chemical compounds. These increased ROS levels can, in turn, lead to oxidative damage of DNA.
Natural plant treatments against cancer can modulate these processes by inducing or decreasing ROS production.

Methods:
Here we report new observations that squamous carcinoma (SCC-25) cells, exposed to 24 hours of
combined resveratrol and berberine treatment, contain increased ROS levels. Using flow cytometry, for drug
activity characteristics, an accumulation of ROS was observed. A combination of different dyes, CellROX
Green (Life Technologies) and DCFH-DA (Sigma), allowed for flow cytometric estimation of levels of cellular
ROS as well as cellular localization.

Results:
Live staining and microscopic observations confirmed the accumulation of ROS in SCC-25 cells following
a combination treatment at concentrations of 10μg/ml. Additionally, the cytotoxicity of the compounds
was significantly improved after their combined application. Additive effects were observed for doses lower
than the calculated IC50 of berberine [IC50=23µg/ml] and resveratrol [IC50=9µg/ml]. Viability (MTS) assays and
analysis of isobolograms revealed a significant impact on cell viability upon combination treatment.

Conclusion:
These results suggest that administration of berberine, in the presence of resveratrol, could be
decreased even to 50% (half the IC50 for berberine) for cancer treatment.
Phycocyanin Extracted from Oscillatoria minima Shows Antimicrobial, Algicidal, and Antiradical Activities: In silico and In vitro Analysis
Authors: Venugopal Vaishali C. , Thakur Abhimanyu , Chennabasappa Latha K. , Mishra Gaurav , Singh Kunal , Rathee Parth , Ranjan Anjali 
Published: April 2019

Background:Phycocyanin is an algae-derived protein, which binds to pigment for harvesting light. It has been reported in various different species, including that of red algae, dinoflagellates, and cryptophyta. Importantly, phycocyanin has enormous applications, including cosmetic colorant, food additive, biotechnology, diagnostics, fluorescence detection probe, an anticancer agent, anti-inflammatory, immune enhancer, etc. In addition, several different algae were utilized for the isolation of cyano-phycocyanin (C-PC), but most of the purification methods consist of several steps of crude extraction.Aim:To isolate C-PC from a new source of microalgae with better purity level and to evaluate its antimicrobial, algicidal, and antiradical activities.Methods:Biological activity, permeability, pharmacokinetics, and toxicity profile of C-PC were predicted by in silico studies. C-PC was purified and isolated by using ammonium sulphate precipitation, ion-exchange chromatography and gel-filtration chromatography. C-PC was characterized by SDS-PAGE and elution profile (purity ratio) analysis. Antimicrobial and algicial activities of C-PC were evaluated by the microtitre plate based assays. Antiradical activity of C-PC was evaluated by DPPH- and ABTS*+ radical scavenging assays.Conclusion:C-PC was extracted from Oscillatoria minima for the first time, followed by its quantitative as well qualitative evaluation, indicating a new alternative source of this important protein. Furthermore, the antimicrobial, algicidal, and antiradical activities of the isolated C-PC extract have been demonstrated by both in silico as well as in vitro methods.
Effect of Conventional and Acid-modified Casein Phosphopeptide-Amorphous Calcium Phosphate Crèmes on Dentin Permeability Before and After Acid Challenge
Authors: Kijsamanmith K , Banomyong D , Burrow MF , Kanchanasantikul P , Wipawiwat S , Srikam S , Laojarungphesatchakorn S 
Published: April 2019

SUMMARY
This study investigated the effect of conventional and acidified casein phosphopeptide-amorphous calcium phosphate–containing crèmes (CPP-ACP and ACPP-ACP) on dentin permeability (DP) before and after acid challenge, using a fluid-flow measuring device and scanning electron microscopic (SEM) examination. Fifty dentin discs were prepared from intact human third molars. Each tooth was sectioned 3 mm above and below the cementoenamel junction. The smear layer was removed to expose the dentin and dentinal tubules. For fluid-flow measurement, 20 specimens were used and divided into two groups: (a) CPP-ACP (pH=7) and (b) ACPP-ACP (pH=2). The dentin surfaces were treated with the crème for five minutes daily for two weeks, and then an acid challenge was performed using 6% citric acid. Under simulated pulpal pressure, DP was measured at baseline, five minutes, two weeks, and after acid challenge. The remaining specimens were prepared and examined using SEM to investigate dentinal tubule occlusion. DP was not significantly different between the two CPP-ACP–containing crèmes at any test period (p≥0.05). DP after two weeks or acid challenge was significantly lower than that at five minutes (p&lt;0.05). The results were consistent with the SEM micrographs that presented patent dentinal tubules after a five-minute application and partial blockage of dentinal tubules after the two-week application. The dentinal tubules remained partially occluded after acid challenge. Using conventional and acid-modified CPP-ACP–containing crèmes for two weeks decreased DP and partially occluded the dentinal tubules, which resisted acid challenge.
BIOLOGICALLY ACTIVE PROPERTIES OF THE ETHANOL AND AQUEOUS EXTRACTS FROM THE NEEDLES OF JUNIPERUS COMMUNIS
Authors: Klepach Halyna , Voloshanska Svitlana , Kovalchuk Halyna , Stopa Aniela 
Published: April 2019

The authors have tested different methods for preparing ethanol and aqueous extracts from the needles of the natural forms of the common juniper and researched some of their biologically active properties. They found 70% ethanol to be the best extractor of bioactive substances from the needles of the common juniper in contrast to 50% and 30% ethanol. They prove that the optimal way to obtain alcohol extracts is crushing the needles of the common juniper to linear sizes: 0.5-2 mm and to infuse in 70 % of ethanol for at least 20 days. Alcohol extracts obtained in this way (10%, g/g) contain polyphenols in the mass concentration of 0.40±0.02 mg/g biomass, ascorbic acid – 1.66±0.1 μg/g of mass and have weak antibacterial properties in relation to the microbiological test culture Escherihia coli, but not in relation to Streptococcus epidermis. A simple and at the same time optimal method to obtain aqueous extracts (10%, g/g) is boiling the uncrushed pieces of J. communis in water for 5 minutes. The aqueous extracts obtained by boiling of both crushed and uncrushed raw materials do not have an antibacterial action on the microbial test cultures.
Rise of China and Russian-Chinese Rapprochement
Authors: Salitsky A. I. , Semenova N. K. 
Published: April 2019

By the mid-2010’s China has continued to impress the world with high economic dynamics, major achievements in social transformation, development of science and technology. The fifth generation of Chinese leaders is determined to offer the country a serious update that signifies, as authors believe, a transition to a new stage of evolution. This stage is characterized by accomplishment of modernization and transition to intensive development, consumer, techno-scientific and ecological revolution. Global economic expansion is an integral part of the new reality.China’s global expansion is of complex nature including credit and overseas investment. Initially it was started by the state after accession to WTO and becomes both more intensive and natural with accomplishment of modernization. At the same time, Beijing stresses the need of self-reliance, particularly in technology. Although in new century China’s expansion to the growing extent was based on economic and market forces including prospering population, by the mid-2010’s it met sharp opposition in the West, notably, the US. That confirmed the notion of emerging new bipolarity in international relations.Moving closer to China, Russia reacted peacefully to Chinese expansion, moreover, a vision of deepening mutual interaction has formed at the political level. This interaction includes multilateral format including countries of Central Asia, interconnection of Eurasian Economic Union with the “Belt and Road” Initiative.
The Indian Ocean as a Zone of Peace: an Outdated Concept or Format for the Future?
Authors: Kupriianov A. V. 
Published: April 2019

The article considers the origins and current perspectives of the concept of the “Indian Ocean as a Zone of Peace” (IOZOP). It was formed within the framework of the Non-Aligned Movement in the 1960s and early 1970s. The concept was supported by the countries of the Indian Ocean Region as the opportunity to avoid the transformation of the Indian Ocean into a zone of conflict between the great powers. Initially formulated very vaguely, in the end the IOZOP concept was reduced mainly to the requirement for non-regional powers to stop testing weapons and deployment of military forces and assets on the islands of the Indian Ocean. Despite the proclamation of the Indian Ocean as a zone of peace by UNGA in 1971, the Western powers ignored this decision, refusing to withdraw its militaryforces and bases from the region. The subsequent disagreements between the regional actors, some of which feared increasing India’s power, and the dramatic change in the political situation in the world led lto a decline in interest in this idea. However, in 2014, India, and Sri Lanka expressed their readiness to put this issue on the agenda again. The author analyzes the history of origin and attempts to realize the concept of the Indian Ocean as a Zone of Peace, the reasons for its failure, highlights the positions of the main countries concerned, key moments that hinder and contribute to the formation of a zone of peace. He concludes that under current conditions, the IOZOP concept can be implemented in an updated form as part of a potential ocean management structure that could be formed on the basis of regional structures such as IORA and IONS.
Trend and spatial variability of 1-day extreme rainfall from 1980 - 2015: study at the adminisitrative area of UPT PSDA Pasuruan
Authors: Indarto Indarto 
Published: April 2019

This study aims to analyze trends, shift and spatial variability of extreme-rainfall in the area of UPT PSDA Pasuruan. The daily rainfall data from 64 stations from 1980 until 2015 were used as main input. The 1-day extreem rainfall data is determined as the maximum annual of 24-hour rainfall events. The statistical analysis using Mann-Kendall, Rank-Sum, and Median Crossing Test using significance level α = 0,05. The spatial variability of extrem rainfall data is described using average annual 24-hour rainfall during the periods of record. Each station is represented by one value. The values are then interpolated using IDW interpolation methods to maps the spatial variability of extreem rainfall event. The results show the value of statistical test for each stations that show the existing trend, shift, or randomness of data. The result also produce thematic maps show the spatial variability of extreme rainfall and the value of each trend.
Evaluation of the Final Time and Velocity of a 100 m Run Under the Realistic Conditions
Authors: Janjić Nataša , Kapor Darko , Doder Dragan , Savić Igor 
Published: April 2019

Abstract
The aim of the research was to provide an analytical expression for the final time and velocity at the 100 m run, taking into account realistic conditions of the run, more precisely the effect of the wind and resistance of the medium (air). Combining the polynomial model for the distance vs time with the solution of the algebraic cubic equation, such an analytical expression was derived. The expression allowed to evaluate the dependence of the final time of the race on the wind velocity. This enabled the quantification of the time effect of the mentioned influences on the final time and velocity. It is possible to calculate the dependence of the sprinter’s velocity on expired running time for various wind velocities (from 0 up to ± 10 m/s) as well as determine the maximal running velocity vmax and corresponding time moment tmax. The results obtained were verified using split time data for six top sprinters: C. Lewis, M. Green, U. Bolt and F. Griffith-Joyner, E. Ashford and H. Drechsler. The results confirmed that it was possible to quantify the time effect of the influence of the wind velocity and resistance of the medium on the final time of the 100 m run. Although the applicability of the approach was tested using the data concerning top sprinters, the mathematical expressions involved are simple enough to be used by any coach to estimate the results of a sprinter under various weather conditions.
The Inter-Session Reliability of Isometric Force-Time Variables and the Effects of Filtering and Starting Force
Authors: Moir Gavin L. , Getz Aaron , Davis Shala E. , Marques Mário , Witmer Chad A. 
Published: April 2019

AbstractThe purposes of the present study were to assess the inter-session reliability of force-time variables recorded during isometric back squats and also to assess the effects of applying a filter to the data prior to analysis and assess the effects of different starting force thresholds on the force-time variables. Eleven resistance trained men (age: 22.5 ± 1.9 years; body mass: 90.3 ± 13.5 kg) attended two sessions where they performed isometric squats on force plates allowing the determination of force-time variables of maximal isometric force (Fmax) and different measures of the rate of force development (RFD). The force-time variables were calculated from both raw and filtered force signals. The start of the force application was determined using force thresholds of 1% or 5% of body mass (BM). Inter-session reliability for the force-time measures was assessed by calculating the intraclass correlation coefficient (ICC) and the coefficient of variation (CV) of the measures. The ICC and CV ranged from 0.03 to 0.96 and 4.6 to 168%, respectively. The application of the filter significantly reduced Fmax and peak RFD (p < 0.004) and increased the reliability of the peak RFD. The use of the 5% BM threshold increased the magnitude of many of the RFD measures (p < 0.004) and resulted in slight improvements in the reliability of these measures although the resulting temporal shift in the force-time signal would preclude accurate assessment of the early phase of the RFD (< 100 ms). The use of a 1% BM starting force threshold without a filter is recommended when using the isometric back squat protocol presented here. Furthermore, the RFD calculated within specific time intervals is recommended
The Glycemic Index of Sport Nutrition Bars Affects Performance and Metabolism During Cycling and Next‐Day Recovery
Authors: Kaviani Mojtaba , Chilibeck Philip D. , Jochim Jennifer , Gordon Julianne , Zello Gordon A. 
Published: April 2019

Abstract
Low-glycemic index carbohydrates are potentially better for endurance performance as they result in greater fat oxidation and lower carbohydrate oxidation due to lower insulin release. We compared the effects of pre-exercise feeding with a low-glycemic index lentil-based sports nutrition bar, a commercially-available sports nutrition bar with moderate-glycemic index, and a non-caloric placebo on metabolism and performance during endurance cycling (Trial 1). Using a randomized, counterbalanced, crossover design, endurance-trained individuals (n = 11; eight males; 26 ± 6y; VO2peak 51.4 ± 1.6 mL/kg/min) consumed 1.5 g/kg available carbohydrate from a lentil bar and a moderate-glycemic index bar, as well as a placebo, 1h before endurance cycling (75 min at 65% VO2peak, followed by a 7 km time trial). We also compared post-exercise consumption of the low-glycemic index bar with another moderate-glycemic index bar on next-day exercise performance as an assessment of recovery (Trial 2). In Trial 1, fat or carbohydrate oxidation rates were not different between the bar conditions (p > 0.05). Blood lactate was lower during the low- versus the moderate-glycemic index condition after 75 minutes of cycling (2.6 versus 4.0 mmol/L, p < 0.05) and at the end of the time trial (7.4 versus 9.1 mmol/L, p < 0.05). Time trial performance improved (p < 0.05) after consumption of the low- (574 ± 55 s) and moderate-glycemic index (583 ± 59 s) bars compared to the placebo (619 ± 81 s). In Trial 2 (next-day recovery), performance improved (p < 0.05) with the low-glycemic index bar (547 ± 42 s) compared to the moderate-glycemic index bar (569 ± 42 s) and the placebo (566 ± 34 s). Low- and moderate-glycemic index sports nutrition bars improved cycling exercise performance; however, only the low-glycemic index bar improved next day performance.
Training Loads, Wellness And Performance Before and During Tapering for a Water-Polo Tournament
Authors: Botonis Petros G. , Toubekis Argyris G. , Platanou Theodoros I. 
Published: April 2019

Abstract
We investigated the effectiveness of a short-duration training period including an overloaded (weeks 1 and 2) and a reduced training load period (weeks 3 and 4) on wellness, swimming performance and a perceived internal training load in eight high-level water-polo players preparing for play-offs. The internal training load was estimated daily using the rating of perceived exertion (RPE) and session duration (session-RPE). Perceived ratings of wellness (fatigue, muscle soreness, sleep quality, stress level and mood) were assessed daily. Swimming performance was evaluated through 400-m and 20-m tests performed before (baseline) and after the end of weeks 2 and 4. In weeks 3 and 4, the internal training load was reduced by 19.0 ± 3.8 and 36.0 ± 4.7%, respectively, compared to week 1 (p = 0.00). Wellness was improved in week 4 (20.4 ± 2.8 AU) compared to week 1 and week 2 by 16.0 ± 2.2 and 17.3 ± 2.9 AU, respectively (p =0.001). At the end of week 4, swimming performance at 400-m and 20-m tests (299.0 ± 10.2 and 10.2 ± 0.3 s) was improved compared to baseline values (301.4 ± 10.9 and 10.4 ± 0.4 s, p < 0.05) and the overloading training period (week 2; 302.9 ± 9.0 and 10.4 ± 0.4 s, p < 0.05). High correlations were observed between the percentage reduction of the internal training load from week 4 to week 1 (-25.3 ± 5.5%) and the respective changes in 20-m time (-2.1 ± 2.2%, r = 0.88, p < 0.01), fatigue perception (39.6 ± 27.1%), muscle soreness (32.5 ± 26.6%), stress levels (25.6 ± 15.1%) and the overall wellness scores (28.6 ± 21.9%, r = 0.74-0.79, p < 0.05). The reduction of the internal training load improved the overall perceived wellness and swimming performance of players. The aforementioned periodization approach may be an effective training strategy in the lead-up to play-off tournaments.
Multi- to Single-Joint or the Reverse Exercise Order does not Affect Pectoralis Major Workout Performance
Authors: Senna Gilmar Weber , Willardson Jeffrey Michael , Scudese Estevão , Simão Roberto , de Oliveira Cristiano Queiroz , de Oliveira Lima Jadson , Silva-Grigoletto Marzo Edir Da , Dantas Estélio Henrique Martin 
Published: April 2019

Abstract
The purpose of this study was to examine the acute effects of multi- to single-joint or the reverse exercise order on repetition performance and perceived exertion for the pectoralis major. Fourteen trained men (24.05 ± 4.17 yrs, 78.85 ± 3.51 kg, 175.42 ± 4.01 cm) underwent two different training sequences (SEQ1 and SEQ2). In SEQ1, all subjects performed 5 sets for maximal repetitions, with a 2-min rest interval, of the bench press followed by the machine chest fly with 10 repetitions maximum load. In SEQ2, the same procedures were repeated, but with the reverse order. The t-test did not show any differences (p = 0.140) in total workout repetitions between SEQ1 (62.22 ± 11.00 repetitions) and SEQ2 (55.40 ± 8.51 repetitions). Conversely, the total repetition number for the bench press exercise was significantly greater (p = 0.001) following SEQ1 (34.36 ± 4.68 repetitions) compared to SEQ2 (25.85 ± 6.73 repetitions). In contrast, the total repetition number for the machine chest fly exercise following SEQ2 was significantly greater (p = 0.001) (33.50 + 4.11 repetitions) compared to SEQ1 (27.85 ± 6.52 repetitions). Despite no significant differences found for the rating of perceived exertion (RPE) values between SEQ1 and SEQ2 for the barbell bench press in all sets (p ≥ 0.083), significantly higher RPE values for the machine chest fly were observed over the first three sets following SEQ1 compared to SEQ2 (p < 0.01). In conclusion, the total workout repetitions were not significantly different when performing the traditional multi- to single-joint or the reverse exercise order when training the pectoralis major muscle.