bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glikogen Otot Rangka Ayam Broiler (Gallus gallus) setelah Pemberian Teh Kombucha dalam Air Minum
Authors: Fathoni Nasrul , Djaelani M Anwar , Isdadiyanto Sri 
Published: January 2019

Kombucha tea beverage obtained by fermenting sweetened green tea for 12 days with Acetobacter xylinum and Saccharomyces which produce various kinds of organic acids, vitamins, and acts as a probiotic. The role of kombucha tea as a growth promoter is to that improve the metabolic process in the digestion of broiler chickens, so that nutrients can and fulfilled optimally for growth and development. The aim of this research was to analyze the sceletal muscle glycogen glycogen (Gallus gallus) after treat with kombucha tea in drinking water. Kombucha tea used is the result of fermentation of green tea for 12 days. This research used DOC chickens (Day Old Chicken) as much as 20 randomly divided into 4 treatments with concentration ie 0%, 10%, 20%, and 40% kombucha tea in drinking water for 32 days. The variables measured were skeletal muscle glycogen levels, body weight, feed consumption and drink consumption. The data obtained were analyzed using ANOVA followed by Duncan Test with 95% confidence level using SPSS 17.0 software. The results of this study showed that kombucha tea on skeletal muscle glycogen and feed consumption showed no significant difference, while on body weight and drink consumption showed significantly different results. Based on the results of the study, it can be concluded that giving kombucha tea in drinking water to a concentration of 40% has not been able to affect the skeletal muscle glycogen in broiler chickens. Key words: Kombucha tea, broiler chicken, glycogen skeletal muscle
Kadar Kolesterol Daging Pada Keturunan F1 Dari Induk Puyuh Jepang (Coturnix coturnix japonica L.) Yang Diberi Suplemen Tepung Kunyit (Curcuma longa L.) Dalam Pakan
Authors: Andriani Regita , Saraswati Tyas Rini , Tana Silvana 
Published: January 2019

Quail is one of poultry commodities that compliance the needed of animal protein like egg and meat. Good quality was breed from quail parent that has good physiological condition. This research aimed to quantified cholesterol of quail meat from F1 from quail parent that treatment using turmeric powder supplement on itsfed in order to obtained best quail chick with good physiological condition. This research use Completely Randomized Design (CRD) experimental method. Animal on this research was 15 Japanese quail (Coturnix coturnix japonica L.) hens that gave 3 treatments with 5 repetitions. K0 was F1 of quail parent without turmeric powder supplementation, K1 was F1 of quail parent with 54 mg/quail/day turmeric powder supplementation before its sex period, K2 was F1 of quail parent with 108 mg/quail/day turmeric powder supplementation before its sex period. The F1 quail was fed using standard quail feed. Data was obtained from daily fed consumption average, daily water consumption, and quail meat cholesterol rate on 60 day old chicken. Data was analyses using Analysis of Variance (ANOVA). This research result showed that daily fed consumption, daily water consumption and meat cholesterol rate of F1 that treatment using turmeric powder supplementation wasn’t show significant difference, so conclusion of this research is physiological condition of F1 was normal. Key words: Quail Meat Cholesterol, F1 of Japanese quail (Coturnix coturnix japonica), Turmeric powder
Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors
Authors: Rankin Kelsey A. , Mei Feng , Kim Kicheol , Shen Yun-An A. , Mayoral Sonia R. , Desponts Caroline , Lorrain Daniel S. , Green Ari J. , Baranzini Sergio E. , Chan Jonah R. , Bove Riley 
Published: January 2019

A significant unmet need for patients with multiple sclerosis (MS) is the lack of U.S. Food and Drug Administration (FDA)-approved remyelinating therapies. We have identified a compelling remyelinating agent, bazedoxifene (BZA), a European Medicines Agency (EMA)-approved (and FDA-approved in combination with conjugated estrogens) selective estrogen receptor (ER) modulator (SERM) that could move quickly from bench to bedside. This therapy stands out as a tolerable alternative to previously identified remyelinating agents and other candidates within this family. Using an unbiased high-throughput screen, with subsequent validation in both murine and human oligodendrocyte precursor cells (OPCs) and coculture systems, we find that BZA enhances differentiation of OPCs into functional oligodendrocytes. Using anin vivomurine model of focal demyelination, we find that BZA enhances OPC differentiation and remyelination. Of critical importance, we find that BZA acts independently of its presumed target, the ER, in bothin vitroandin vivosystems. Using a massive computational data integration approach, we independently identify six possible candidate targets through which SERMs may mediate their effect on remyelination. Of particular interest, we identify EBP (encoding 3β-hydroxysteroid-Δ8,Δ7-isomerase), a key enzyme in the cholesterol biosynthesis pathway, which was previously implicated as a target for remyelination. These findings provide valuable insights into the implications for SERMs in remyelination for MS and hormonal research at large.SIGNIFICANCE STATEMENTTherapeutics targeted at remyelination failure, which results in axonal degeneration and ultimately disease progression, represent a large unmet need in the multiple sclerosis (MS) population. Here, we have validated a tolerable European Medicines Agency-approved (U.S. Food and Drug Administration-approved in combination with conjugated estrogens) selective estrogen receptor (ER) modulator (SERM), bazedoxifene (BZA), as a potent agent of oligodendrocyte precursor cell (OPC) differentiation and remyelination. SERMs, which were developed as nuclear ER-α and ER-β agonists/antagonists, have previously been implicated in remyelination and neuroprotection, following a heavy focus on estrogens with underwhelming and conflicting results. We show that nuclear ERs are not required for SERMs to mediate their potent effects on OPC differentiation and remyelinationin vivoand highlight EBP, an enzyme in the cholesterol biosynthesis pathway that could potentially act as a target for SERMs.
A thymus szerkezete a huszonegyedik század elején
Authors: Bódi Ildikó , H.-Minkó Krisztina , Prodán Zsolt , Nagy Nándor , Oláh Imre 
Published: January 2019

Abstract: The classical histological features of the thymus are the cortex and medulla, the Hassall’s bodies as well as the lobules. Anti-pan-cytokeratin immunocytochemistry shows that the keratin staining pattern of the cortical and medullary epithelial cells is different. The medulla is further compartmentalized: it consists of keratin-positive network and keratin-negative areas. Histology of the keratin-negative area is identical with the connective tissue of the septae. The basal lamina is continuous at the capsule and septae, but it becomes discontinuous at the border between the keratin-positive network and keratin-negative area. This immunohistochemical finding is the first histological sign, which may explain that the medulla has no blood-thymus barrier. The supporting tissue of the keratin-negative area is identical with that of the septae. The connective tissue of thymic capsule and septae develops from the cranial neural crest cells, therefore we hypothesize that the keratin-negative area has neural crest origin. Blood vessels of the thymic medulla localize in the keratin-negative area. Every emigrating or immigrating immunologically competent cells should enter the keratin-negative area, therefore this area is the transit zone of the thymus. The hematoxylin-eosin staining of the thymus shows that the thymic cortico-medullary border does not represent cellular background. However, the border between keratin-positive network and keratin-negative area is determined by cellular identity (epithelial and mesenchymal tissues). Therefore, it can be assumed that the real histological and functional border is the border between the keratin-positive network and the keratin-negative area. Orv Hetil. 2019; 160(5): 163–171.
Mellkasi sérültek drenázsadatainak vizsgálata
Authors: Csonka Ákos , Dózsai Dávid , Ecseri Tamás , Gárgyán István , Csonka István , Varga Endre 
Published: January 2019

Abstract: Introduction: Chest injuries cause a significant number of pneumothorax (PTX) and hemothorax (HTX). The most commonly used treatment is chest-tube drainage. The position of the tube is a prime necessity to achieve adequate drainage. Aim: To analyze the duration of chest drainage at the occurrence of PTX and HTX. To find what the underlying cause of drainage insufficiency is and whether there is any relation between the surgical qualification needed to the procedure. Method: Clinical data of 110 injured patients from 2011 to 2015 were collected and retrospectively analyzed. In the case of tube breaking or drainage insufficiency it was investigated if repositioning, usage of new tubes or insertion of additional tubes resolved the drainage insufficiency. Authors investigated the location of the tube on x-ray and CT, and the connection between the drainage insufficiency and the surgical qualifications needed to the procedure. Results: The average duration of chest drainage was 6.5 days. The duration of drainage was shorter by 1.9 days regarding the tube inserted in the middle section of the chest compared to the upper one and shorter by 1.2 days regarding the tube inserted in the lower section of the chest compared to the upper one. In the case of HTX, the duration of drainage was shorter by 2.8 days regarding the lower and by 3.6 days regarding the middle section compared to the upper position. Drainage insufficiency occurred in 30% of all cases. The duration of chest drainage was shorter after application of new tubes (9.5 days) than after reposition (10.2 days), but there was no significant difference. Conclusion: Chest injury is a wide entity, thus one standard protocol cannot be developed on the management of these injuries. Authors concluded that drainage duration decreases significantly if the position of the tube is in the middle or lower section of the chest. The high occurrence of drainage insufficiency was caused by inadequate tube positioning and tube breaking. The practical qualification of trauma surgeons did not play a significant role regarding the prevalence of drainage insufficiency rather if the tube positioning was appropriate. Orv Hetil. 2019; 160(5): 172–178.
A májfunkció romlásának rizikófaktorai sikeres vesetranszplantációt követően
Authors: Borda Bernadett , Nemes Attila , Lengyel Csaba , Várkonyi Tamás , Rárosi Ferenc , Keresztes Csilla , Ottlakán Aurél , Lázár György 
Published: January 2019

Abstract: Introduction: Increase of liver function is one of the most common complications after kidney transplantation due to the use of immunosuppressive therapy and hyperlipidemia in addition to hepatitis C virus (HCV) infection. Method: Following the selection criteria (n = 59), the study is based on applied immunosuppressive therapy, baseline data of patients, further correlation between HCV and liver function deterioration. Patients were subjected to fasting laboratory examination to monitor serum electrolytes, uric acid and albumin levels. We looked at the effects of immunosuppressive therapy on the lipids (TG, TC, HDL, LDL) and liver enzymes (GOT, GPT, ALP, GGT). The analysis of the relationship between lipids and liver enzymes was also included in our study. Results: The data basics were not significantly different between the tacrolimus and the cyclosporine groups. In the laboratory results, Mg levels were significantly different between the two groups (p = 0.044). The impact of HCV on the liver function was significantly different on GGT (p = 0.008). We examed the lipids and liver function level between the tacrolimus and the patients receiving cyclosporine-based immunosuppression and the total cholesterol (p = 0.005) and GOT (p = 0.05) were significantly different between the two groups. Hyperlipidemia was associated with 26% of patients taking tacrolimus-based immunosuppression, and 89% of those receiving cyclosporine; the difference was significant (p = 0.002). Regarding the effect of hyperlipidemia on liver enzymes, ALP (p = 0.006) and GGT (p = 0.0001) were significantly higher. Conclusion: Increases in hepatic enzymes, ALT and GGT indicate the damage to hepatocytes. Beside the increase of liver function, which is the main risk factor in hepatitis on HCV soil, the applied immunosuppressive therapy and hyperlipidemia lead to degradation of allograft function and long-term graft loss. Orv hetil. 2019; 160(5): 186–190.
Sıddîk Hasan Hân’ın Taklîde Karşı Duruşunun Kur’ânî Argümanları
Authors: Tayfur Sabğatullah 
Published: January 2019

Sıddîk Hasan
Hân (ö. 1889/1307),
Hindistan’ın önde gelen İslâm âlimlerindendir. Değişik ilim dalında birçok eser
yazmıştır. Hindistan’ın ilim merkezi haline gelmesinde büyük katkılarda
bulunmuştur. Birçok dinî konuda görüş beyan etmiştir. Bunların çoğunda selef-i
sâlihe uymuştur. Onun en çok dikkat çeken görüşlerinden birisi taklîd
hakkındaki düşünceleridir. O, bu konuda çok katı bir anlayışa sahiptir. Bundan
dolayı birçok âlim tarafından eleştiriye tabi tutulmuştur. Ona göre zarurî durumlar dışında hiçbir
konuda gayr-i müslimlere ait bir mantık olan taklîde başvurulmamalıdır. Çünkü
taklîd, delilsiz bir şekilde başkalarına uyma olduğu için cehalet
sayılmaktadır. Ona göre taklîd, insanı sahîh bilgiye ulaştırma konusunda
güvenilir bir yöntem değildir. Çünkü bu yöntem sorgusuz bir şekilde başkalarına
uymaktan ibarettir. O, taklîd yerine iki sağlam yöntem önermektedir. Bunlar
ittibâ‘ ve ictihâddır. İnsanlar, taklîd yerine Kur’ân’a, sünnete ve selef-i
sâlihe ittibâ‘ etmeli ya da ictihâdda bulunmalıdırlar.
Limb-girdle muscular dystrophy due to GMPPB mutations: A case report and comprehensive literature review
Authors: Sun LiuQing , Shen DingGuo , Xiong Ting , Zhou Zhibin , Lu Xianghui , Cui Fang 
Published: January 2019

Mutations in the guanosine diphosphate mannose (GDP-mannose) pyrophosphorylase B (GMPPB) gene are rare. To date, 72 cases with GMPPB gene mutations have been reported. Herein, we reported a case of a 29-year-old Chinese male presenting with limb-girdle muscular dystrophy (LGMD) who was found to have two heterozygous GMPPB mutations. The patient had a progressive limb weakness for 19 years. His parents and elder brother were normal. On examination he had a waddling gait, and absent tendon reflexes in all four limbs. Electromyography showed myogenic damage. Muscle magnetic resonance imaging (MRI) showed fatty degeneration in the bilateral medial thigh muscles. High throughput gene panel sequencing revealed that the patient carried compound heterozygous mutations in the GMPPB gene, c.553C>T (p.R185C, maternal inheritance) and c.346C>T (p.P116S, paternal inheritance). This case provides additional information regarding the phenotypic spectrum of GMPPB mutations in the Chinese population.
A REVIEW STUDY ON ONLINE PSYCHO-EDUCATION FOR THE BIPOLAR DISORDER PATIENT AND THEIR CAREGIVERS
Authors: Fitriani Nurlaila , Suryadi Iwan 
Published: January 2019

Purpose: Identify some recent research on the use of online-based psychoeducation intervention for people with bipolar disorders and online education for their family. The process of searching uses keywords: mHealth, eHealth, a smartphone application, web-based, relatives, caregiver, psychoeducation, and bipolar disorders
Methodology: 60 articles discuss bipolar disorder, only 10 articles are suitable for the inclusion criteria. The various program was created to deal with bipolar disorder problems for both patients and their families. Online psychoeducation is effective for people with bipolar disorder to overcome barriers in the management of direct intervention. Reporting complaints, symptoms and often uncontrolled feelings can be done immediately by using the program.
Main Findings: Online psychoeducation is effective for people with bipolar disorder to overcome barriers in the management of direct intervention. Online psychoeducation can also save costs and facilitate access and services to obtain information that is needed by patients and their families. Reporting complaints, symptoms and often uncontrolled feelings can be done immediately by using the program. For the families, online intervention is very effective because of the availability of information are felt to be very effective of information on how to handle people bipolar disorder as well as details about self-control management for themselves.
Applications: Online psychoeducation should continue to develop not only for the patient but also for primary family caregivers. This article collects, analyze and confirm the requirement of online psychoeducation.
Novelty: Author did this study by reviewing published literature. This kind of analysis is first time done by the author for the suitability of online psychoeducation for bipolar disorder patients and their family.
STUDY OF FOOD SECURITY THROUGH FOOD WASTE AND LOSS CONTROL MECHANISM IN KENYA
Authors: Were Simon O , Miricho M N , Maranga N V 
Published: January 2019

Food waste within the hospitality’s restaurant operations contribute immensely to the global food wastes, and studies reveal that it contributes 45% of wastes through food preparation and production processes, 21% through food spoilage as a result of poor storage and 34% through food leavers as observed from customer plates. Further, research confirms that food wastage has directly resulted in the starvation of over 842 million people, with over 1.3 billion tons documented as food wastages, while substantial amounts of this food waste and losses taking place within the larger hospitality restaurant’s operations.
The factors influencing these food waste generation included; the type of service, the type of food served, the expected and actual numbers of customers, the season and the food service organization, which are addressed by this study in an attempt to propose ways of reducing food waste and losses, and hence promoting food security.
The study narrows down to the prevention solutions approach, which was employed on the basis of; menu design, portion choices and customized dishes, use of smaller plates during service, procuring optimized quantities, proper application of product specifications, and employment of waste tracking and analytics methodologies, which when appropriately applied in the restaurant food operations business will significantly reduce food waste and losses, and by extension global food insecurity.
APPLICATION OF GEOSPATIAL TECHNIQUES IN THE LOCATIONAL PLANNING OF HEALTH CARE CENTERS IN MINNA, NIGERIA
Authors: Olubadewo-Joshua Oluwaseun , Ugom Kenneth Michael 
Published: January 2019

Access to health care is an important component of an overall health system and a major indicator of growth. Health care planning and Geographic Information System (GIS) are two relevant fields that depend upon spatial data. GIS plays an essential role in helping public health organizations to understand population health and make decisions with the powerful tools and situation that GIS technology provides. The purpose of the study to investigated the spatial distribution of health care centers in Minna, Nigeria with a view to use Geographic Information System (GIS) technique in health care management and planning. The method is a qualitative research that is used in making decisions in order to have a strong understanding of government policies and programs. Beyond the many uses of a GIS in health applications, the greatest power of a GIS lies in its ability to integrate information from disparate sources. Traffic disturbances and poor road network were observed to be the major factors militating against effective health care facilities location in the study area.

Keywords: Geographic Information Systems, Healthcare, Planning, Remote Sensing, Research

© 2018 Department of Geography Education, University of Jember
THE EFFECT OF VEHICLES INTENSITY IN SUMBERSARI JEMBER REGENCY
Authors: Sari Eva Kurnia , Pramesty Dinda Ayu 
Published: January 2019

The main problem is vehicles very much owned by the public of Indonesia. One of transportation that is used population usefulness as a tool for mobility to a place that will be addressed, from rural to urban areas or vice versa. Community needs more triggers the movement of people from one place to another. Highway average - average be passed by a motorcycle and a car. Geography and transport have a very close relationship. The purpose of this study was to analyze the density of the vehicle in the sumbersari area of Kabupaten Jember. The method used is a survey using a sample area. The results showed that vehicle density most often occurs in the morning and evening.

Keywords: mobility, effective today, the volume of vehicles

© 2018 Department of Geography Education, University of Jember
A correlation between self concept and procrastination based on gender in neuroscience perspective
Authors: Syabilla Yussa Annisa , Suryanda Ade , Sigit Diana Vivanti 
Published: January 2019

One of the responsibilities of students is to work on academic tasks in a disciplined manner. The problem that arises is when students have a tendency to delay their academic assignments. This is called academic procrastination. Academic procrastination is procrastinating behavior in carrying out academic assignments. One of the internal factors that is important to study related to procrastination is academic self-concept. Self-concept becomes a personality style that is important to be explored further in research on procrastination because a person tends to act in line with the self-concept possessed. There have been many studies conducted related to procrastination. Internal factors of academic procrastination aside from psychological factors also have physiological factors such as neuro activity. This research was conducted at SMAN 44 Jakarta in April-May 2018. The research method used was quantitative descriptive method. The sample used is 120 XI MIPA students. Based on the calculation results obtained normal and homogeneous distributed data. The result of hypothesis testing shows that academic self concept has negative correlation with academic procrastination and rxy is -0473. The academic self concept has a contribution of 22.4% in determining the academic procrastination of learners on Biology subjects. This research implies that the importance of improving students 'academic self-concept, especially for teachers, is expected to be able to do Biology learning with methods that can develop students' academic self-concept.
Achievement and response of students at favorite junior high schools in sukabumi on trends in international mathematics and science study (timss) questions
Authors: Suhendar Suhendar , Wahyuni Ayi 
Published: January 2019

The research is aimed to know student achievement and teacher response on TIMSS. The research method used is descriptive. This achievement is captured the TIMSS questions in 2007 and 2011 on the ecosystem concept. The test contains 20 questions consisting of 14 essays and 6 multiple choice questions. The TIMSS questions also consist of several cognitive domains of knowing, applying and reasoning. Responses of students and teachers were collected through questionnaires and interviews. The study subjects are class VIII B 1 of School A and class VIII E School B 2 of Sukabumi in the academic year of 2015/2016. The results show that average achievement in School A is in the poor category (41%) and School B is in the fair category (56%). The achievements based on cognitive domain, 80% for knowing the domain, 43% for applying domain and 53% reasoning domain. Some students of School A and most of the students of School B feel interested in TIMSS problem, while the teachers think that TIMSS questions will be used if it already familiar.