bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stochastic dynamics of fluid–structure interaction in turbulent thermal convection
Authors: Huang Jinzi Mac , Zhong Jin-Qiang , Zhang Jun , Mertz Laurent 
Published: September 2018

The motion of a free-moving plate atop turbulent thermal convection exhibits diverse dynamics that displays characteristics of both deterministic and chaotic motions. Early experiments performed by Zhong & Zhang (Phys. Rev. E, vol. 75 (5), 2007, 055301) found an oscillatory and a trapped state existing for a plate floating on convective fluid in a rectangular tank. They proposed a piecewise smooth physical model (ZZ model) that successfully captures this transition of states. However, their model was deterministic and therefore could not describe the stochastic behaviours. In this study, we combine the ZZ model with a novel approach that models the stochastic aspects through a variational inequality structure. With the powerful mathematical tools for stochastic variational inequalities, the properties of the Markov process and corresponding Kolmogorov equations could be studied both numerically and analytically. Moreover, this framework also allows one to compute the transition probabilities. Our present work captures the stochastic aspects of the two aforementioned boundary–fluid coupling states, predicts the stochastic behaviours and shows excellent qualitative and quantitative agreements with the experimental data.
On the maximal spreading of impacting compound drops
Authors: Liu H.-R. , Zhang C.-Y. , Gao P. , Lu X.-Y. , Ding H. 
Published: September 2018

We numerically study the impact of a compound drop on a hydrophobic substrate using a ternary-fluid diffuse-interface method, aiming to understand how the presence of the inner droplet affects the spreading dynamics and maximal spreading of the compound drop. First, it is interesting to see that the numerical results for an impacting pure drop agree well with the universal rescaling of maximal spreading ratio proposed by Lee et al. (J. Fluid Mech., vol. 786, 2016, R4). Second, two flow regimes have been identified for an impacting compound drop: namely jammed spreading and joint rim formation. The maximal spreading ratio of the compound drop is found to depend on the volume fraction of the inner droplet $\unicode[STIX]{x1D6FC}$, the surface tension ratio $\unicode[STIX]{x1D6FE}$, the Weber number and the flow regime. Moreover, we propose a universal rescaling of maximal spreading ratio for compound drops, by integrating the one for pure drops with a corrected Weber number that takes $\unicode[STIX]{x1D6FC}$, $\unicode[STIX]{x1D6FE}$ and the flow regime into account. The predictions of the universal rescaling are in good agreement with the numerical results for impacting compound drops.
Ocean-excited plate waves in the Ross and Pine Island Glacier ice shelves
Authors: CHEN ZHAO , BROMIRSKI PETER D. , GERSTOFT PETER , STEPHEN RALPH A. , WIENS DOUGLAS A. , ASTER RICHARD C. , NYBLADE ANDREW A. 
Published: September 2018

AbstractIce shelves play an important role in buttressing land ice from reaching the sea, thus restraining the rate of grounded ice loss. Long-period gravity-wave impacts excite vibrations in ice shelves that can expand pre-existing fractures and trigger iceberg calving. To investigate the spatial amplitude variability and propagation characteristics of these vibrations, a 34-station broadband seismic array was deployed on the Ross Ice Shelf (RIS) from November 2014 to November 2016. Two types of ice-shelf plate waves were identified with beamforming: flexural-gravity waves and extensional Lamb waves. Below 20 mHz, flexural-gravity waves dominate coherent signals across the array and propagate landward from the ice front at close to shallow-water gravity-wave speeds (~70 m s−1). In the 20–100 mHz band, extensional Lamb waves dominate and propagate at phase speeds ~3 km s−1. Flexural-gravity and extensional Lamb waves were also observed by a 5-station broadband seismic array deployed on the Pine Island Glacier (PIG) ice shelf from January 2012 to December 2013, with flexural wave energy, also detected at the PIG in the 20–100 mHz band. Considering the ubiquitous presence of storm activity in the Southern Ocean and the similar observations at both the RIS and the PIG ice shelves, it is likely that most, if not all, West Antarctic ice shelves are subjected to similar gravity-wave excitation.
What Makes Cooperatives Successful? Identifying the Determinants of Their Organizational Performance
Authors: Fanasch Patrizia , Frick Bernd 
Published: September 2018

AbstractIn comparison with other organizational forms, cooperatives have been found to offer poor product quality and suffer from low reputation. The main reasons discussed in the literature are information asymmetries, which leads to adverse selection and moral hazard, as well as the absence of profit orientation due to poorly specified and diluted property rights. However, although, in reality, many cooperatives indeed perform poorly, and some are apparently able to completely avoid or at least reduce the problems that are considered prototypical for this hybrid organizational form. Therefore, the purpose of this study is to identify the characteristics required to reduce the problems resulting from poorly specified property rights and information asymmetries and, hence, to successfully compete in the market. The data we use to identify the characteristics that separate “good” and “bad” cooperatives encompass 136 organizations in Austria, Germany, and northern Italy. Our logistic regression estimations show that older and larger cooperatives (in terms of acreage) have a significantly higher probability to be listed in at least one of two highly respected wine guides. Moreover, German cooperatives have a significantly lower probability of being listed than either Austrian or northern Italian cooperatives. The findings suggest that differences in performance can be explained by the management of cooperatives. (JEL Classifications: D23, D82, D86, J54, L22, L25, L66, P13, Q13)
Geochronology and physical context of Oldowan site formation at Kanjera South, Kenya
Authors: DITCHFIELD P. W. , WHITFIELD E. , VINCENT T. , PLUMMER T. , BRAUN D. , DEINO A. , HERTEL F. , OLIVER J. S. , LOUYS J. , BISHOP L. C. 
Published: September 2018

AbstractOldowan sites in primary geological context are rare in the archaeological record. Here we describe the depositional environment of Oldowan occurrences at Kanjera South, Kenya, based on field descriptions and granulometric analysis. Excavations have recovered a large Oldowan artefact sample as well as the oldest substantial sample of archaeological fauna. The deposits at Kanjera South consist of 30 m of fluvial, colluvial and lacustrine sediments. Magneto- and biostratigraphy indicate the Kanjera South Member of the Kanjera Formation was deposited during 2.3–1.92 Ma, with 2.0 Ma being a likely age for the archaeological occurrences. Oldowan artefacts and associated fauna were deposited in the colluvial and alluvial silts and sands of beds KS1–3, in the margins of a lake basin. Field descriptions and granulometric analysis of the sediment fine fraction indicate that sediments from within the main archaeological horizon were emplaced as a combination of tractional and hyperconcentrated flows with limited evidence of debris-flow deposition. This style of deposition is unlikely to significantly erode or disturb the underlying surface, and therefore promotes preservation of surface archaeological accumulations. Hominins were repeatedly attracted to the site locale, and rapid sedimentation, minimal bone weathering and an absence of bone or artefact rounding further indicate that fossils and artefacts were quickly buried.
JURISDICTION IN TORT CLAIMS FOR NON-PHYSICAL HARM UNDER BRUSSELS 2012, ARTICLE 7(2)
Authors: Hartley Trevor C 
Published: September 2018

AbstractArticle 7(2) of the Brussels Regulation, 2012 confers jurisdiction, in matters relating to tort, on the courts of the Member State in which the harmful event occurred. In Bier v Mines de Potasse d'Alsace, the CJEU held that this covers both the place where the event which caused the damage takes place and the place where the damage itself takes place. In later cases, however, it held that does not cover the place where the victim claims to have suffered financial damage following upon initial damage arising and suffered by the victim in another Member State. A problem arises if there is no physical harm but only financial loss or some other kind of non-physical harm. It is not always clear in such a situation where the damage occurs. This article considers this problem with special reference to pure financial loss but also two other torts in which no physical harm occurs: defamation and intellectual-property infringement.
Anti-Trichomonas vaginalis activity of 1,10-phenanthroline-5,6-dione-based metallodrugs and synergistic effect with metronidazole
Authors: Vargas Rigo Graziela , Petro-Silveira Brenda , Devereux Michael , McCann Malachy , Souza dos Santos André Luis , Tasca Tiana 
Published: September 2018

AbstractTrichomonas vaginalis is responsible for the most common non-viral, sexually transmitted infection, human trichomoniasis, and is associated with an increased susceptibility to HIV. An escalation in resistance (2.5–10%) to the clinical drug, metronidazole (MTZ), has been detected and this compound also has adverse side-effects. Therefore, new treatment options are urgently required. Herein, we investigate the possible anti-T. vaginalis activity of 1,10-phenanthroline-5,6-dione (phendione) and its metal complexes, [Ag(phendione)2]ClO4 and [Cu(phendione)3](ClO4)2·4H2O. Minimum inhibitory concentration (MIC) against T. vaginalis ATCC 30236 and three fresh clinical isolates and mammalian cells were performed using serial dilution generating IC50 and CC50 values. Drugs combinations with MTZ were evaluated by chequerboard assay. A strong anti-T. vaginalis activity was found for all test compounds. IC50 values obtained for [Cu(phendione)3](ClO4)2·4H2O were similar or lower than those obtained for MTZ. In vitro assays with normal cells showed low cytotoxicity and [Cu(phendione)3](ClO4)2·4H2O presented a high selectivity index (SI) for fibroblasts (SI = 11.39) and erythrocytes (SI > 57.47). Chequerboard assay demonstrated that the combination of [Cu(phendione)3](ClO4)2·4H2O with MTZ leads to synergistic interaction, which suggests distinct mechanisms of action of the copper–phendione complex and avoiding the MTZ resistance pathways. Our results highlight the importance of phendione-based drugs as potential molecules of pharmaceutical interest.
Notes on troubling ‘the popular’
Authors: Cole Ross 
Published: September 2018

AbstractThis article throws new light on the troublesome question ‘what is popular music?’ by pursuing a genealogy of discourse in Britain during a crucial period from 1860 to 1920 in which modernity is increasingly characterised by an antagonistic relationship between intellectual elites and consumer entertainment. Focusing on London music halls, social reformism and ragtime, I argue that the term fell into two broad categories of use: first, to identify and/or denigrate mass culture; and second, to establish a pathway for edification and to champion ideals of respectability. Although implicated in the construction of binary oppositions and frequently associated with impropriety, the popular was not always associated with lowness. The idea, however, was shot through with contradictions deriving from a view of ‘the people’ as being simultaneously docile and seditious. Ultimately, I demonstrate that the popular is a floating signifier with the potential to reference mutually opposing ideas.
Sigur Rós: reception, borealism, and musical style
Authors: Størvold Tore 
Published: September 2018

AbstractSince the international breakthrough of The Sugarcubes and Björk in the late 1980s, the Anglophone discourse surrounding Icelandic popular music has proven to be the latest instance of a long history of representation in which the North Atlantic island is imagined as an icy periphery on the edge of European civilization. This mode of representation is especially prominent in the discourse surrounding post-rock band Sigur Rós. This article offers a critical reading of the band's reception in the Anglo-American music press during the period of their breakthrough in the UK and USA. Interpretative strategies among listeners and critics are scrutinised using the concept of borealism (Schram 2011) in order to examine attitudes towards the Nordic regions evident in the portrayals of Sigur Rós. Reception issues then form the basis for a musical analysis of a seminal track in the band's history, aiming to demonstrate how specific details in Sigur Rós's style relate to its reception and the discourse surrounding it. The article finds that much of the metaphorical language present in the band's reception can be linked to techniques of musical spatiality, the unusual sound of the bowed electric guitar and non-normative uses of voice and language.
A spatial and temporal analysis of risk factors associated with sporadic Shiga toxin-producingEscherichia coliO157 infection in England between 2009 and 2015
Authors: Elson Richard , Grace Katherine , Vivancos Roberto , Jenkins Claire , Adak Goutam K. , O'Brien Sarah J. , Lake Iain R. 
Published: September 2018

AbstractInfection with STEC O157 is relatively rare but has potentially serious sequelae, particularly for children. Large outbreaks have prompted considerable efforts designed to reduce transmission primarily from food and direct animal contact. Despite these interventions, numbers of infections have remained constant for many years and the mechanisms leading to many sporadic infections remain unclear.Here, we show that two-thirds of all cases reported in England between 2009 and 2015 were sporadic. Crude rates of infection differed geographically and were highest in rural areas during the summer months. Living in rural areas with high densities of cattle, sheep or pigs and those served by private water supplies were associated with increased risk. Living in an area of lower deprivation contributed to increased risk but this appeared to be associated with reported travel abroad. Fresh water coverage and residential proximity to the coast were not risk factors.To reduce the overall burden of infection in England, interventions designed to reduce the number of sporadic infections with STEC should focus on the residents of rural areas with high densities of livestock and the effective management of non-municipal water supplies. The role of sheep as a reservoir and potential source of infection in humans should not be overlooked.
A Large Committed Long‐Term Sink of Carbon due to Vegetation Dynamics
Authors: Pugh T. A. M. , Jones C. D. , Huntingford C. , Burton C. , Arneth A. , Brovkin V. , Ciais P. , Lomas M. , Robertson E. , Piao S. L. , Sitch S. 
Published: September 2018

AbstractThe terrestrial biosphere shows substantial inertia in its response to environmental change. Hence, assessments of transient changes in ecosystem properties to 2100 do not capture the full magnitude of the response realized once ecosystems reach an effective equilibrium with the changed environmental boundary conditions. This equilibrium state can be termed the committed state, in contrast to a transient state in which the ecosystem is in disequilibrium. The difference in ecosystem properties between the transient and committed states represents the committed change yet to be realized. Here an ensemble of dynamic global vegetation model simulations was used to assess the changes in tree cover and carbon storage for a variety of committed states, relative to a preindustrial baseline, and to attribute the drivers of uncertainty. Using a subset of simulations, the committed changes in these variables post‐2100, assuming climate stabilization, were calculated. The results show large committed changes in tree cover and carbon storage, with model disparities driven by residence time in the tropics, and residence time and productivity in the boreal. Large changes remain ongoing well beyond the end of the 21st century. In boreal ecosystems, the simulated increase in vegetation carbon storage above preindustrial levels was 20–95 Pg C at 2 K of warming, and 45–201 Pg C at 5 K, of which 38–155 Pg C was due to expansion in tree cover. Reducing the large uncertainties in long‐term commitment and rate‐of‐change of terrestrial carbon uptake will be crucial for assessments of emissions budgets consistent with limiting climate change.
Climatology and Characteristics of Medium‐Scale F Region Ionospheric Plasma Irregularities Observed by COSMIC Radio Occultation Receivers
Authors: Watson C. , Pedatella N. M. 
Published: September 2018

AbstractMedium‐scale ionospheric ionization structures are a persistent global feature of the Earth's ionosphere. Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) radio occultation measurements are well suited to address the incomplete global observational picture of plasma density irregularities, including the global climatology in both bottomside and topside F region layers, and their structure in the vertical dimension. A climatological database of F region ionospheric irregularities and their characteristics has been developed through detection of total electron content perturbations by Global Positioning System receivers onboard COSMIC satellites. This paper presents global occurrence rates and detailed characteristics of equatorial to midlatitude medium‐scale irregularities under quiet geomagnetic conditions. The study covers 4 years, two during solar minimum (2008–2009) and two during the ascending phase of solar cycle 24 (2012–2013). Irregularities were found to occur frequently at high latitudes and during nighttime in equatorial to midlatitude regions in both bottom and topside F region layers. Longitudinal‐seasonal occurrence trends at equatorial and midlatitudes are consistent with previous irregularity climatology, which reaffirms that localized enhancements in plasma instability growth rates contribute to irregularity occurrence. Seasonal occurrence patterns also indicate a high occurrence of irregularities in regions corresponding to the solar terminator, confined primarily to altitudes below ~300 km. The local time‐altitude distributions of equatorial and midlatitude irregularity occurrence, amplitude, and scale size provide further insight into irregularity generation mechanisms, and include features consistent with “spread F” irregularities and traveling ionospheric disturbances.
Decadal Trends in Wet Sulfur Deposition in China Estimated From OMI SO2 Columns
Authors: Zhang X. Y. , Chuai X. W. , Liu L. , Zhang W. T. , Lu X. H. , Zhao L. M. , Chen D. M. 
Published: September 2018

AbstractLong‐term (from 2005 to 2016) trends in wet SO42− deposition across China are assessed using Ozone Monitoring Instrument (OMI) SO2 columns within the planetary boundary layer. The models for estimating monthly SO42− deposition from precipitation in eight ecological regions are constructed based on SO2 columns and ground‐based measurements. An accuracy assessment shows that the models achieve highly precise predictive values for monthly deposition (R = 0.93, with a relative/absolute error of −0.1/0.3 kg S · ha−1 · month−1). In terms of spatial distribution, SO42− deposition shows substantial variations across China, ranging from 0.9 to 63.9 kg S · ha−1 · year−1, with an average of 10.4 kg S · ha−1 · year−1. Additionally, wet SO42− deposition shows significant seasonal variations, increasing from January to July and then decreasing thereafter. Regarding long‐term trends, the wet SO42− deposition in northern, central, and southern China decreased at rates of 0.009, 0.001, and 0.0009 kg S · ha−1 · month−1, respectively. In contrast, Inner Mongolia, Qinghai‐Tibet, and northwest and northeast China showed increasing deposition trends. In general, the wet SO42− deposition in 2016 decreased by 4.3% from that in 2005 on a national scale, indicating that air quality policies to control SO2 emissions have had some effects on wet SO42− deposition.
Glucose-regulated protein 78 binds to and regulates the melanocortin-4 receptor
Authors: Yoon Ye Ran , Lee Tae-Gul , Choi Mi-Hyun , Shin Seung Woo , Ko Young-Gyu , Rhyu Im Joo , Kim Dong-Hoon , Seong Je Kyung , Baik Ja-Hyun 
Published: September 2018

AbstractThe melanocortin-4 receptor (MC4R) belongs to the G protein-coupled receptor (GPCR) family and plays an essential role in the control of energy homeostasis. Here, we identified a novel MC4R-interacting protein, glucose-regulated protein 78 (GRP78), from a pulldown assay using hypothalamic protein extracts and the third intracellular loop of MC4R. We found that MC4R interacted with GRP78 in both the cytosol and at the cell surface and that this interaction increased when MC4R was internalized in the presence of the agonist melanotan-II (MTII). Downregulation of GRP78 using a short interfering RNA approach attenuated MTII-mediated receptor internalization. Reduction in GRP78 expression during tunicamycin-induced endoplasmic reticulum stress also suppressed MTII-mediated internalization of MC4R and cAMP-mediated transcriptional activity. Furthermore, lentiviral-mediated short hairpin RNA knockdown of endogenous GRP78 in the paraventricular nucleus (PVN) of the hypothalamus resulted in an increase in body weight in mice fed a high-fat diet. These results suggest that GRP78 in the PVN binds to MC4R and may have a chaperone-like role in the regulation of MC4R trafficking and signaling.
Kindlin-2 regulates hepatic stellate cells activation and liver fibrogenesis
Authors: Yu Jun , Hu Yinan , Gao Yi , Li Qinghai , Zeng Zhilin , Li Yong , Chen Huilong 
Published: September 2018

AbstractLiver fibrosis, the common response associated with chronic liver diseases, ultimately leads to cirrhosis, a major public health problem worldwide. Activation of hepatic stellate cells (HSCs) by transforming growth factor (TGF)-β1 is a key step in liver fibrosis. Here we report that Kindlin-2 expression is elevated in the livers of mice with experimental liver fibrosis and also in the livers of patients with liver fibrosis. TGF-β1 increases Kindlin-2 expression in cultured HSCs in a p38 and ERK mitogen-activated protein kinase (MAPK)-dependent manner, partly. More importantly, Kindlin-2 deficiency significantly attenuated mouse liver fibrosis and HSC activation. Mechanistically, Kindlin-2 promotes TGF-β signaling through upregulation of Smad2 and Smad3 phosphorylation. Our work demonstrates an important role for Kindlin-2 in liver fibrosis, and inhibiting Kindlin-2 in the livers may represent a novel strategy to treat liver fibrosis.