bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of sunlight exposure on mortality of patients with end stage renal disease
Authors: Yoon Una Amelia , Kim Yong Chul , Lee Hyewon , Kwon Soie , An Jung Nam , Kim Dong Ki , Kim Yon Su , Lim Chun Soo , Lee Jung Pyo , Kim Ho 
Published: February 2019

AbstractRecent data suggest that reduced sunlight exposure is associated with increased mortality in the general population. To date, the association between sunlight exposure and mortality in dialysis patients has not been examined. Among 134,478 dialysis patients in the Korean end-stage renal disease (ESRD) cohort from 2001 to 2014, 31,291 patients were enrolled from seven metropolitan cities, and data were analyzed using bi-directional case-crossover design. We examined the association between short-term sunlight exposure and mortality in ESRD patients. We adjusted for temperature, humidity, and daily concentrations of nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), carbon monoxide (CO), and particle matter (PM10) as confounders. The characteristics of the study population included age (65.6 ± 12.26 (mean ± standard deviation [SD]) years), sex (male, 59.96%; female, 41.04%), comorbidity (diabetes, 53.58%; hypertension, 40.5%), and kidney dialysis type (hemodialysis, 73.02%; peritoneal dialysis, 26.98%). The mean ± SD follow-up time was 4.68 ± 4.37 years. The daily sunlight exposure was significantly decreased in the case group compared with the control group (P = 0.004). Sunlight exposure was associated with all-cause death overall (ORs [95% CI]: 0.99 [0.98–0.99], P = 0.042) in a fully adjusted model. Patients with diabetes (ORs [95% CI]: 0.98 [0.97–0.99], P = 0.016) or aged higher than 75 years (ORs [95% CI]; 0.97 [0.96–0.99], P = 0.020) had higher risks of mortality than patients without diabetes or aged below 75 years, respectively. These findings suggest that sunlight exposure is inversely correlated with all-cause mortality in dialysis patients.
Persistent autonomic dysfunction and bladder sensitivity in primary dysmenorrhea
Authors: Oladosu Folabomi A. , Hellman Kevin M. , Ham Paula J. , Kochlefl Laura E. , Datta Avisek , Garrison Ellen F. , Steiner Nicole D. , Roth Genevieve E. , Tu Frank F. 
Published: February 2019

AbstractMenstrual pain, also known as dysmenorrhea, is a leading risk factor for bladder pain syndrome (BPS). A better understanding of the mechanisms that predispose dysmenorrheic women to BPS is needed to develop prophylactic strategies. Abnormal autonomic regulation, a key factor implicated in BPS and chronic pain, has not been adequately characterized in women with dysmenorrhea. Thus, we examined heart rate variability (HRV) in healthy (n = 34), dysmenorrheic (n = 103), and BPS participants (n = 23) in their luteal phase across a bladder-filling task. Both dysmenorrheic and BPS participants reported increased bladder pain sensitivity when compared to controls (p’s < 0.001). Similarly, dysmenorrheic and BPS participants had increased heart rate (p’s < 0.01), increased diastolic blood pressure (p’s < 0.01), and reduced HRV (p’s < 0.05) when compared to controls. Dysmenorrheic participants also exhibited little change in heart rate between maximum bladder capacity and after micturition when compared to controls (p = 0.013). Our findings demonstrate menstrual pain’s association with abnormal autonomic activity and bladder sensitivity, even two weeks after menses. Our findings of autonomic dysfunction in both early episodic and chronic visceral pain states points to an urgent need to elucidate the development of such imbalance, perhaps beginning in adolescence.
Significance of urinary C-megalin excretion in vitamin D metabolism in pre-dialysis CKD patients
Authors: Toi Norikazu , Inaba Masaaki , Ishimura Eiji , Tsugawa Naoko , Imanishi Yasuo , Emoto Masanori , Hirayama Yoshiaki , Nakatani Shinya , Saito Akihiko , Yamada Shinsuke 
Published: February 2019

AbstractSerum 1,25(OH)2D and 24,25(OH)2D are decreased in CKD. Megalin in proximal tubular epithelial cells reabsorbs glomerular-filtered 25(OH)D-DBP complex to convert 25(OH)D to 1,25(OH)2D and 24,25(OH)2D. Urinary C-megalin excretion is increased via exocytosis from injured nephrons overloaded with megalin-mediated protein metabolism. This study investigated the significance of urinary C-megalin excretion in vitamin D metabolism in 153 pre-dialysis CKD patients. Urinary C-megalin was positively associated with urinary protein, β2MG and α1MG, and exhibited negative correlations with serum 25(OH)D, 1,25(OH)2D and 24,25(OH)2D. Multiple regression analysis showed that urinary C-megalin had a significantly negative association with 25(OH)D. Serum 1,25(OH)2D and 24,25(OH)2D, as well as 1,25(OH)2D/25(OH)D and 24,25(OH)2D/25(OH)D ratios, showed positive correlations with eGFR. Additionally, wholePTH was positively associated with 1,25(OH)2D/25(OH)D and 1,25(OH)2D/24,25(OH)2D, while FGF23 was positively associated with 24,25(OH)2D/25(OH)D and negatively with 1,25(OH)2D/24,25(OH)2D. Urinary C-megalin emerged as an independent factor positively associated with 1,25(OH)2D/25(OH)D and 1,25(OH)2D/24,25(OH)2D. Although 1,25(OH)2D and 24,25(OH)2D are decreased in CKD patient serum, our findings suggest that PTH and FGF23 retain their effects to regulate vitamin D metabolism even in the kidneys of these patients, while production of 1,25(OH)2D and 24,25(OH)2D from 25(OH)D is restricted due to either impairment of megalin-mediated reabsorption of the 25(OH)D-DBP complex or reduced renal mass.
Metabolic adaptation of adherent-invasive Escherichia coli to exposure to bile salts
Authors: Delmas Julien , Gibold Lucie , Faïs Tiphanie , Batista Sylvine , Leremboure Martin , Sinel Clara , Vazeille Emilie , Cattoir Vincent , Buisson Anthony , Barnich Nicolas , Dalmasso Guillaume , Bonnet Richard 
Published: February 2019

AbstractThe adherent-invasive Escherichia coli (AIEC), which colonize the ileal mucosa of Crohn’s disease patients, adhere to intestinal epithelial cells, invade them and exacerbate intestinal inflammation. The high nutrient competition between the commensal microbiota and AIEC pathobiont requires the latter to occupy their own metabolic niches to survive and proliferate within the gut. In this study, a global RNA sequencing of AIEC strain LF82 has been used to observe the impact of bile salts on the expression of metabolic genes. The results showed a global up-regulation of genes involved in degradation and a down-regulation of those implicated in biosynthesis. The main up-regulated degradation pathways were ethanolamine, 1,2-propanediol and citrate utilization, as well as the methyl-citrate pathway. Our study reveals that ethanolamine utilization bestows a competitive advantage of AIEC strains that are metabolically capable of its degradation in the presence of bile salts. We observed that bile salts activated secondary metabolism pathways that communicate to provide an energy benefit to AIEC. Bile salts may be used by AIEC as an environmental signal to promote their colonization.
Association between Poor Sleep Quality and Subsequent Peptic Ulcer Recurrence in Older Patients with Mild Cognitive Impairment: Examining the Role of Social Engagement
Authors: Fang Boye , Yang Shuyan , Xu Ruirui , Chen Gengzhen 
Published: February 2019

AbstractThis study aims to examine whether perceived poor sleep quality predicts subsequent recurrence of peptic ulcer disease (PUD) in older patients with mild cognitive impairment following Helicobacter pylori eradication and to investigate whether social engagement status alters this association. Of 1,689 older patients with H. pylori-infected PUD recruited from eight Grade-A hospitals in the People’s Republic of China between 2011 and 2014, H. pylori was eradicated and PUD cleared in 1,538 patients by the end of 2014; 1,420 of these were followed for up to 36 months. The Kaplan–Meier method was used to compare the proportion of PUD recurrence, as confirmed with esophagogastroduodenoscopy, among older patients with different levels of sleep quality and social engagement statuses. Multivariate Cox-proportional hazards models were performed to examine the association between sleep quality and PUD recurrence, and the role of social engagement in altering this relationship. The results showed that PUD recurrence was more prevalent in poor (10.8%) compared with good sleepers (5.5%). However, increased and continued social engagement reduced the proportion to 7.2% and 8.2% among poor sleepers, respectively. Poor sleep quality was associated with subsequent PUD recurrence (hazard ratio [HR] 1.965 (1.002, 3.518)). However, no significant difference was observed between good and poor sleepers who reported increased (HR 1.428 (0.736, 2.380)) and continued (HR 1.273 (0.915, 2.492)) social engagement, suggesting that increased and continued social engagement prevented the effect of poor sleep quality on PUD recurrence. To conclude, poor sleep quality is associated with subsequent PUD recurrence. However, increased and continued social engagement may moderate this association.
Precancer antiviral treatment reduces microvascular invasion of early-stage Hepatitis B-related hepatocellular carcinoma
Authors: Liu Kai , Duan Jicheng , Liu Hu , Yang Xinwei , Yang Jiahe , Wu Mengchao , Chang Yanxin 
Published: February 2019

AbstractThe impact of antiviral therapy before tumorigenesis on microvascular invasion (MVI) of Chronic hepatitis B (CHB)-related hepatocellular carcinoma (HCC) is still unknown. In this retrospective cohort study 3,276 HCC patients with early-stage who underwent curative resection were included. We investigated the effect of precancer antiviral therapy on the pathology, especially MVI, of CHB-related HCC. MVI occurrence rates of CHB-related HCC stratified by histopathologic inflammation grades of G1, G2, and G3 were 30.4%, 34.7%, and 38.6%, respectively, compared to 19.8% for CHB-negative HCC. Patients who received standard antiviral treatment showed much lower rates of MVI, higher tumor capsule integrity, less frequent satellite micronodules and lower AFP level compared to the no antiviral group. Moreover, precancer antiviral therapy prolonged the disease-free survival (DFS), which are also proved to be independent indicators of DFS. In addition, we show that antivirals may suppress early progression of HCC primarily by inhibition of HBV viral load, and influencing the expression levels of CK18, GPC3, OPN and pERK. Hence, we demonstrate that precancer antivirals significantly reduce the MVI rate of CHB-related HCC, reduce malignancy of early-stage HCC, and improve HCC prognosis. Thus, this study confirms the importance of antiviral therapy for CHB patients.
Immobilization of Peroxidase on Functionalized MWCNTs-Buckypaper/Polyvinyl alcohol Nanocomposite Membrane
Authors: Jun Lau Yien , Mubarak N. M. , Yon Lau Sie , Bing Chua Han , Khalid Mohammad , Jagadish Priyanka , Abdullah E. C. 
Published: February 2019

AbstractSurface modified Multi-walled carbon nanotubes (MWCNTs) Buckypaper/Polyvinyl Alcohol (BP/PVA) composite membrane was synthesized and utilized as support material for immobilization of Jicama peroxidase (JP). JP was successfully immobilized on the BP/PVA membrane via covalent bonding by using glutaraldehyde. The immobilization efficiency was optimized using response surface methodology (RSM) with the face-centered central composite design (FCCCD) model. The optimum enzyme immobilization efficiency was achieved at pH 6, with initial enzyme loading of 0.13 U/mL and immobilization time of 130 min. The results of BP/PVA membrane showed excellent performance in immobilization of JP with high enzyme loading of 217 mg/g and immobilization efficiency of 81.74%. The immobilized system exhibited significantly improved operational stability under various parameters, such as pH, temperature, thermal and storage stabilities when compared with free enzyme. The effective binding of peroxidase on the surface of the BP/PVA membrane was evaluated and confirmed by Field emission scanning electron microscopy (FESEM) coupled with Energy Dispersive X-Ray Spectroscopy (EDX), Fourier transform infrared spectroscopy (FTIR) and Thermogravimetric Analysis (TGA). This work reports the characterization results and performances of the surface modified BP/PVA membrane for peroxidase immobilization. The superior properties of JP-immobilized BP/PVA membrane make it promising new-generation nanomaterials for industrial applications.
Association between peroxisome proliferator-activated receptor γ-2 gene Pro12Ala polymorphisms and risk of hypertension: an updated meta-analysis
Authors: Zhang Miao , Zhang Jianping , Li Lifeng , Wang Qiang , Feng Limin 
Published: February 2019

Abstract
Previous studies investigate the relationship between peroxisome proliferator-activated receptor γ-2 (PPAR) gene Pro12Ala polymorphisms and risk of hypertension. However, the number of available studies was extremely limited. We updated this evidence and gave more significant results. We performed comprehensive computer-based searches in the PubMed, Web of Science, Embase, Google Scholar, the Cochrane library, Wanfang database, China National Knowledge Infrastructure, and China Biological Medicine Database. All studies that reported the association between the PPARγ2Pro12Ala polymorphisms and hypertension were identified. Twenty-one studies were finally included in the present study. In the domain model, the PPARγ1Pro12Ala polymorphism was not associated with hypertension (odds ratio (OR) = 0.85, 95% confidence interval (CI): 0.71–1.03, P=0.108). The significant relationship was found in the recessive model (OR = 0.67, 95% CI: 0.53–0.85), in the additive model (OR = 0.61, 95% CI: 0.48–0.77), and in the allele genetic model (OR = 0.81, 95% CI: 0.66–0.99). Subgroup analysis indicated that the PPARγ1Pro12Ala polymorphism from the all gene models was also not related to the risk of hypertension in Caucasians. In Asians, however, the results (P=0.002; I2 = 57.6%) suggested a significant relationship between PPARγ1Pro12Ala and hypertension in the domain model (OR = 0.80, 95% CI: 0.65–0.99), in the recessive model (OR = 0.57, 95% CI: 0.44–0.75), in the additive model (OR = 0.51, 95% CI: 0.39–0.66), and in the allele model (OR = 0.75, 95% CI: 0.60–0.94). The PPARγ1Pro12Ala polymorphism could affect the risk of primary hypertension amongst Asians. The A allele gene was a protective genotype for primary hypertension. The PPARγ1Pro12Ala polymorphism was not associated with hypertension amongst Caucasians.
Dynamical structure of the pulsating atmosphere of RR Lyrae
Authors: Gillet D. , Mauclaire B. , Lemoult T. , Mathias Ph. , Devaux J.-S. , de France Th. , Garrel T. ,   the GRRR Collaboration
Published: February 2019

Context. RRab stars are large amplitude pulsating stars in which the pulsation wave is a progressive wave. Consequently, strong shocks, stratification effects, and phase lag may exist between the variations associated with line profiles formed in different parts of the atmosphere, including the shock wake. The pulsation is associated with a large extension of the expanding atmosphere, and strong infalling motions are expected.
Aims. The objective of this study is to provide a general overview of the dynamical structure of the atmosphere occurring over a typical pulsation cycle.
Methods. We report new high-resolution observations with high time resolution of Hα and sodium lines in the brightest RR Lyrae star of the sky: RR Lyr (HD 182989). A detailed analysis of line profile variations over the whole pulsation cycle is performed to understand the dynamical structure of the atmosphere.
Results. The main shock wave appears when it exits from the photosphere at φ ≃ 0.89, i.e., when the main Hα emission is observed. Whereas the acceleration phase of the shock is not observed, a significant deceleration of the shock front velocity is clearly present. The radiative stage of the shock wave is short: 4% of the pulsation period (0.892 < φ < 0.929). A Mach number M > 10 is required to get such a radiative shock. The sodium layer reaches its maximum expansion well before that of Hα (Δφ = 0.135). Thus, a rarefaction wave is induced between the Hα and sodium layers. A strong atmospheric compression occurring around φ = 0.36, which produces the third Hα emission, takes place in the highest part of the atmosphere. The region located lower in the atmosphere where the sodium line is formed is not involved. The amplification of gas turbulence seems mainly due to strong shock waves propagating in the atmosphere rather than to the global compression of the atmosphere caused by the pulsation. It has not yet been clearly established whether the microturbulence velocity increases or decreases with height in the atmosphere. Furthermore, it seems very probable that an interstellar component is visible within the sodium profile.
La France et la Grande-Bretagne à l’ère de la médecine génomique
Authors: Horn Ruth 
Published: February 2019

L’annonce du plan « France Médecine Génomique 2015 » témoigne de la volonté des pouvoirs publics français de faire de la médecine génomique l’un des éléments phares de la santé publique et de la recherche scientifique nationales. C’est dans ce contexte que la France a annoncé sa coopération avec la Grande-Bretagne, l’un des plus grands leaders mondiaux de la médecine génomique. Une telle collaboration au niveau international impose une réflexion à un cadre normatif commun qui réponde aux nouveaux défis éthiques posés par la médecine génomique. Afin qu’un tel cadre soit adapté aux différents contextes nationaux, il est nécessaire d’identifier et d’analyser les questions éthiques au niveau général et dans leurs contextes particuliers. Dans cette revue, nous discuterons de l’enjeu international de la médecine génomique et, plus précisément, de l’entrée de la France dans la compétition internationale. Nous explorerons ensuite les enjeux éthiques de la médecine génomique en prenant comme étude de cas le contexte prénatal. Nous finirons par une réflexion sur l’impact que peut avoir le contexte national sur la façon dont les questions éthiques émergent en France par rapport à la Grande-Bretagne.
L’évolution dirigée des protéines
Authors: Minard Philippe 
Published: February 2019

Le prix Nobel de chimie a été décernée le 3 octobre 2018 pour moitié à Frances H. Arnold (California Institute of technology, Pasadena, États-Unis) et pour l’autre moitié conjointement à Georges P. Smith (University of Missouri, Columbia, États-Unis) et Sir Greg P. Winter (Medical Research Council et Laboratory of molecular Biology, Cambridge, Royaume-Uni). Ces trois chercheurs ont joué un rôle déterminant dans la genèse puis le développement d’un ensemble d’approches originales que l’on regroupe aujourd’hui sous l’expression « évolution dirigée des protéines ».
Krankheitskosten – Behandlungskosten chronischer Wunden sind höher als
angenommen
Authors: Fietz Cornelia 
Published: February 2019

Nussbaum SR et al. An Economic Evaluation of the Impact, Cost, and Medicare
Policy Implications of Chronic Nonhealing Wounds. Value Health 2018; 21:
27–32
Trotz möglicher, schwerwiegender Komplikationen wie Amputation oder Tod sind
die Behandlungskosten chronischer Wunden weitgehend unbekannt, da sie häufig
ambulant versorgt werden. Nussbaum und Kollegen führen eine retrospektive
Analyse von Medicare-Patientendaten durch, um die Prävalenz verschiedener
Wundtypen und die zugehörigen Behandlungskosten zu ermitteln.
Krankenversicherung – Rettet die Prämiendifferenzierung das niederländische
System der Krankenzusatzversicherung?
Authors: Fietz Cornelia 
Published: February 2019

van Winssen KPM et al. Can premium differentiation counteract adverse selection
in the Dutch supplementary health insurance? A simulation study. Eur J Health
Econ 2018; 19: 757–768
In der niederländischen Krankenzusatzversicherung zeichnet sich eine
Antiselektion ab: Immer weniger Einwohner schließen eine
Krankenzusatzversicherung ab oder wählen günstigere Versicherungspolicen mit
weniger umfassender Abdeckung als zuvor. Folglich sinken die Gewinne für die
Versicherungen, die Prämien steigen und Personen mit niedrigem Risiko
reduzieren aufgrund der hohen Kosten ihren Versicherungsschutz oder kündigen
die Zusatzversicherung – es entsteht ein Teufelskreis, der zu einer
Instabilität des Krankenversicherungsmarktes führt. Die Autoren simulieren,
ob eine Prämiendifferenzierung der Antiselektion entgegenwirken
kann.
Glücksspiel – Online-Glücksspiele und ihr Einfluss auf die
Gesundheitsausgaben
Authors: Potempa Christoph 
Published: February 2019

Effertz et al. The effect of online gambling on gambling problems and resulting
economic health costs in Germany. Eur J Health Econ 2018; 19: 967–978
Problematisches Glücksspielverhalten entwickelt sich in vielen Ländern zu
einem ernstzunehmenden Problem, dessen Behandlung auch im deutschen
Gesundheitssystem zu erheblichen Ausgaben führt. Durch die Etablierung des
Online-Glücksspiels hat sich diese Problematik in den vergangenen Jahren
zusätzlich verschärft. Die Autoren um Effertz et al. veranschaulichen in
ihrer Analyse die gesundheitsökonomischen Auswirkungen dieser
Entwicklung.
Deployment of Aziridines for the Synthesis of Alkaloids and Their Derivatives
Authors: D’hooghe Matthias , Ha Hyun-Joon , Macha Lingamurthy 
Published: February 2019

Various (activated and non-activated) aziridines with diverse substitution patterns have been deployed successfully as starting materials for the synthesis of a wide variety of alkaloids via suitable functionalization and aziridine ring transformation. Alternatively, the preparation and interception of reactive aziridine intermediates has also been shown to constitute a valid approach toward alkaloid synthesis. This review summarizes aziridine-mediated syntheses of alkaloids, in which the aziridine is mobilized as either a substrate or an advanced synthetic intermediate.1	Introduction2	Alkaloids Synthesis from Aziridine Starting Materials2.1	(2R)- and (2S)-Hydroxymethyl-N-(1-phenylethyl)aziridines2.2	N-Benzylaziridine-2-carboxylates2.3	2-Substituted N-Tosyl- or N-Tritylaziridines2.4	2,3-Disubstituted N-Cbz- or N-Tosylaziridines2.5	N-DMB-aziridines3	Alkaloids Synthesis from Aziridines as Key Advanced Synthetic Intermediates3.1	Alkylative Aziridine Ring Opening3.2	Arylative Aziridine Ring Opening3.3	Ring Expansion3.4	Oxidative Aziridine Ring Opening3.5	Heteroatomic Nucleophilic Aziridine Ring Opening3.6	Reductive Aziridine Ring Opening4	Conclusion
Endoscope-Assisted Minimally Invasive Microsurgical Removal of a Medium-Sized Acoustic Neuroma (T3a) through a Retrosigmoid Mini-Craniotomy with Preservation of Hearing
Authors: Kurucz Peter , Barany Laszlo , Buchfelder Michael , Ganslandt Oliver 
Published: February 2019

A 45-year-old male patient with reduced hearing in the right ear was diagnosed with a medium-sized (T3a) acoustic neuroma. The operation was performed through an individually tailored retrosigmoid mini-craniotomy. Endoscope-assisted microsurgical technique was applied to early detect the location of the facial and cochlear nerves as well as to look around the hidden corners during the surgery. The entire operation was performed without using brain retractors. The moderate intrameatal extension of the tumor and the use of angled endoscopes allowed to avoid the drilling of the internal auditory meatus. The lesion could be completely removed and the patient showed a satisfactory hearing recovery in the follow-up examinations 3 months after the surgery.The link to the video can be found at: https://youtu.be/dAYLakih924.