bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sunlight-induced photoreduction of Cr(VI) to Cr(III) in wastewater by nitrogen-phosphorus-doped carbon dots
Authors: Bhati Anshu , Anand Satyesh Raj , Saini Deepika , Gunture  , Sonkar Sumit Kumar 
Published: May 2019

AbstractCr(VI) is a known toxic and non-biodegradable pollutant that results from multiple industrial processes, and can cause significant environmental damage if it is not removed from wastewater. However, it can be reduced to Cr(III), which is less toxic and can be readily precipitated out and removed. Here, a fast and facile single-step technique is reported for the synthesis of nitrogen–phosphorus doped fluorescent carbon dots (NP-CD) using a domestic microwave, as a potential photocatalytic material. Under natural sunlight, a simple photocatalytic experiment reveals that the NP-CD are highly efficient for the quantitative reduction of Cr(VI) to Cr(III) in synthetic contaminated water, in a linear range from 10 ppm (in approximately 10 min) to 2000 ppm (in approximately 320 min) by increasing the sunlight irradiation time followed by its removal by precipitation. NP-CD exhibit high recyclability of up to six cycles without any apparent loss in photocatalytic activity, demonstrating NP-CD as a potential photocatalyst material for Cr(VI) water treatment.
Walking and finger tapping can be done with independent rhythms
Authors: Qi Weihuang , Nakajima Tsuyoshi , Sakamoto Masanori , Kato Kouki , Kawakami Yasuo , Kanosue Kazuyuki 
Published: May 2019

AbstractRhythmic movements occur in many aspects of daily life. Examples include clapping the hands and walking. The production of two independent rhythms with multiple limbs is considered to be extremely difficult. In the present study we evaluated whether two different, independent rhythms that involved finger tapping and walking could be produced. In Experiment I, twenty subjects that had no experience of musical instrument training performed rhythmic finger tapping with the right index finger and one of four different lower limb movements; (1) self-paced walking, (2) given-paced walking, (3) alternative bilateral heel tapping from a sitting position, and (4) unilateral heel tapping with the leg ipsilateral to the tapping finger from a sitting position. The target intervals of finger tapping and heel strikes for walking step/heel tapping were set at 375 ms and 600 ms, respectively. The even distribution of relative phases between instantaneous finger tapping and heel strike was taken as the criteria of independency for the two rhythms. In the self-paced walking and given-paced walking tasks, 16 out of 20 subjects successfully performed finger tapping and walking with independent rhythms without any special practice. On the other hand, in the bipedal heels striking and unipedal heel striking tasks 19 subjects failed to perform the two movements independently, falling into interrelated rhythms with the ratio mostly being 2:1. In Experiment II, a similar independency of finger tapping and walking at a given pace was observed for heel strike intervals of 400, 600, and 800 ms, as well as at the constant 375 ms for finger tapping. These results suggest that finger tapping and walking are controlled by separate neural control mechanisms, presumably with a supra-spinal locus for finger tapping, and a spinal location for walking.
Microstructural deformation process of shock-compressed polycrystalline aluminum
Authors: Ichiyanagi Kouhei , Takagi Sota , Kawai Nobuaki , Fukaya Ryo , Nozawa Shunsuke , Nakamura Kazutaka G. , Liss Klaus-Dieter , Kimura Masao , Adachi Shin-ichi 
Published: May 2019

AbstractPlastic deformation of polycrystalline materials under shock wave loading is a critical characteristic in material science and engineering. However, owing to the nanosecond time scale of the shock-induced deformation process, we currently have a poor mechanistic understanding of the structural changes from atomic scale to mesoscale. Here, we observed the dynamic grain refinement of polycrystalline aluminum foil under laser-driven shock wave loading using time-resolved X-ray diffraction. Diffraction spots on the Debye-Scherrer ring from micrometer-sized aluminum grains appeared and disappeared irregularly, and were shifted and broadened as a result of laser-induced shock wave loading. Behind the front of shock wave, large grains in aluminum foil were deformed, and subsequently exhibited grain rotation and a reduction in size. The width distribution of the diffraction spots broadened because of shock-induced grain refinement and microstrain in each grain. We performed quantitative analysis of the inhomogeneous lattice strain and grain size in the shocked polycrysalline aluminum using the Williamson-Hall method and determined the dislocation density under shock wave loading.
Thalamus exhibits less sensory variability quenching than cortex
Authors: Poland Eva , Donner Tobias H. , Müller Kai-Markus , Leopold David A. , Wilke Melanie 
Published: May 2019

AbstractSpiking activity exhibits a large degree of variability across identical trials, which has been shown to be significantly reduced by stimulus onset in a wide range of cortical areas. Whether similar dynamics apply to the thalamus and in particular to the pulvinar is largely unknown. Here, we examined electrophysiological recordings from two adult rhesus macaques performing a perceptual task and comparatively investigated trial-to-trial variability in higher-order thalamus (ventral and dorsal pulvinar), the lateral geniculate nucleus (LGN) and visual cortex (area V4) prior to and following the presentation of a visual stimulus. We found spiking variability during stable fixation prior to stimulus onset to be considerably lower in both pulvinar and the LGN as compared to area V4. In contrast to the prominent variability reduction in V4 upon stimulus onset, variability in the thalamic nuclei was largely unaffected by visual stimulation. There was a small but significant variability decrease in the dorsal pulvinar, but not in the ventral portion of the pulvinar, which is closely connected to visual cortices and would thus have been expected to reflect cortical response properties. This dissociation did not stem from differences in response strength or mean firing rates and indicates fundamental differences in variability quenching between thalamus and cortex.
GREIN: An Interactive Web Platform for Re-analyzing GEO RNA-seq Data
Authors: Mahi Naim Al , Najafabadi Mehdi Fazel , Pilarczyk Marcin , Kouril Michal , Medvedovic Mario 
Published: May 2019

AbstractThe vast amount of RNA-seq data deposited in Gene Expression Omnibus (GEO) and Sequence Read Archive (SRA) is still a grossly underutilized resource for biomedical research. To remove technical roadblocks for reusing these data, we have developed a web-application GREIN (GEO RNA-seq Experiments Interactive Navigator) which provides user-friendly interfaces to manipulate and analyze GEO RNA-seq data. GREIN is powered by the back-end computational pipeline for uniform processing of RNA-seq data and the large number (>6,500) of already processed datasets. The front-end user interfaces provide a wealth of user-analytics options including sub-setting and downloading processed data, interactive visualization, statistical power analyses, construction of differential gene expression signatures and their comprehensive functional characterization, and connectivity analysis with LINCS L1000 data. The combination of the massive amount of back-end data and front-end analytics options driven by user-friendly interfaces makes GREIN a unique open-source resource for re-using GEO RNA-seq data. GREIN is accessible at:https://shiny.ilincs.org/grein, the source code at:https://github.com/uc-bd2k/grein, and the Docker container at:https://hub.docker.com/r/ucbd2k/grein.
A Pavlovian account for paradoxical effects of motivation on controlling response vigour
Authors: Oudiette Delphine , Vinckier Fabien , Bioud Emmanuelle , Pessiglione Mathias 
Published: May 2019

AbstractIn high stakes situations, people sometimes choke under pressure, performing below their abilities. Here, we suggest a novel mechanism to account for this paradoxical effect of motivation: the automatic adjustment of action vigour to potential reward. Although adaptive on average, this mechanism may impede fine motor control. Such detrimental effect was observed in three studies (n = 74 in total), using behavioural tasks where payoff depended on the precision of handgrip squeezing or golf putting. Participants produced more force for higher incentives, which aggravated their systematic overshooting of low-force targets. This reward bias was specific to action vigour, as reward did not alter action timing, direction or variability across trials. Although participants could report their reward bias, they somehow failed to limit their produced force. Such an automatic link between incentive and force level might correspond to a Pavlovian response that is counterproductive when action vigour is not instrumental for maximizing reward.
Common spatiotemporal processing of visual features shapes object representation
Authors: Papale Paolo , Betta Monica , Handjaras Giacomo , Malfatti Giulia , Cecchetti Luca , Rampinini Alessandra , Pietrini Pietro , Ricciardi Emiliano , Turella Luca , Leo Andrea 
Published: May 2019

AbstractBiological vision relies on representations of the physical world at different levels of complexity. Relevant features span from simple low-level properties, as contrast and spatial frequencies, to object-based attributes, as shape and category. However, how these features are integrated into coherent percepts is still debated. Moreover, these dimensions often share common biases: for instance, stimuli from the same category (e.g., tools) may have similar shapes. Here, using magnetoencephalography, we revealed the temporal dynamics of feature processing in human subjects attending to objects from six semantic categories. By employing Relative Weights Analysis, we mitigated collinearity between model-based descriptions of stimuli and showed that low-level properties (contrast and spatial frequencies), shape (medial-axis) and category are represented within the same spatial locations early in time: 100–150 ms after stimulus onset. This fast and overlapping processing may result from independent parallel computations, with categorical representation emerging later than the onset of low-level feature processing, yet before shape coding. Categorical information is represented both before and after shape, suggesting a role for this feature in the refinement of categorical matching.
Enhanced photocatalytic performance of a Ti-based metal-organic framework for hydrogen production: Hybridization with ZnCr-LDH nanosheets
Authors: Sohail Muhammad , Kim Hyunuk , Kim Tae Woo 
Published: May 2019

AbstractNovel hybrid composites of NH2-MIL-125(Ti) and ZnCr-layered double hydroxide nanosheets (ZnCr-LDH NSs) are developed for use as visible-light-active photocatalysts for hydrogen production based on water photolysis. The hybrid composites are obtained by growing NH2-MIL-125(Ti) in the presence of exfoliated ZnCr-LDH NSs using a solvothermal reaction. Hybridization of NH2-MIL-125(Ti) with exfoliated ZnCr-LDH NSs leads to significant effects on the morphology and optical properties of NH2-MIL-125(Ti). To find the optimum photocatalytic activity for hydrogen production by the hybrid composite photocatalysts, the content of ZnCr-LDH in this work is controlled. Compared to that of pristine NH2-MIL-125(Ti) and ZnCr-LDH, the hybrid composites exhibit an improved photocatalytic activity for hydrogen production under visible-light irradiation. In addition, the hybrid composite photocatalyst shows excellent photo-chemical stability. The improved photocatalytic activity is believed to benefit from the synergy of strong electronic coupling between NH2-MIL-125(Ti) and ZnCr-LDH NSs, expanded light absorption and band alignment to enhance the lifetime of photo-induced electrons and holes.
ERP evidence on how gaze convergence affects social attention
Authors: Wang Nanbo , Xu Shan , Zhang Shen , Luo Yiqi , Geng Haiyan 
Published: May 2019

AbstractHow people process gaze cues from multiple others is an important topic but rarely studied. Our study investigated this question using an adapted gaze cueing paradigm to examine the cueing effect of multiple gazes and its neural correlates. We manipulated gaze directions from two human avatars to be either convergent, created by the two avatars simultaneously averting their gazes to the same direction, or non-convergent, when only one of the two avatars shifted its gaze. Our results showed faster reaction times and larger target-congruency effects following convergent gazes shared by the avatars, compared with the non-convergent gaze condition. These findings complement previous research to demonstrate that observing shared gazes from as few as two persons is sufficient to enhance gaze cueing. Additionally, ERP analyses revealed that (1) convergent gazes evoked both left and right hemisphere N170, while non-convergent gazes evoked N170 mainly in the hemisphere contralateral to the cueing face; (2) effects of target congruency on target-locked N1 and P3 were modulated by gaze convergence. These findings shed light on temporal features of the processing of multi-gaze cues.
Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major
Authors: Moitra Samrat , Pawlowic Mattie C. , Hsu Fong-fu , Zhang Kai 
Published: May 2019

AbstractPhosphatidylcholine (PC) is a major cell membrane constituent and precursor of important second messengers. In Leishmania parasites, PC synthesis can occur via the choline branch of the Kennedy pathway, the N-methylation of phosphatidylethanolamine (PE), or the remodeling of exogenous phospholipids. To investigate the role of de novo PC synthesis in Leishmania major, we focused on the cholinephosphate cytidylyltransferase (CPCT) which catalyzes the formation of CDP-choline, a key intermediate in the choline branch of the Kennedy pathway. Without CPCT, L. major parasites cannot incorporate choline into PC, yet the CPCT-null mutants contain similar levels of PC and PE as wild type parasites. Loss of CPCT does not affect the growth of parasites in complete medium or their virulence in mice. These results suggest that other mechanisms of PC synthesis can compensate the loss of CPCT. Importantly, CPCT-null parasites exhibited severe growth defects when ethanolamine and exogenous lipids became limited or when they were co-cultured with certain bacteria that are known to be members of sandfly midgut microbiota. These findings suggest that Leishmania employ multiple PC synthesis pathways to utilize a diverse pool of nutrients, which may be crucial for their survival and development in the sandfly.
Mechanism study of photo-induced gold nanoparticles formation by Shewanella oneidensis MR-1
Authors: Huang Bo Chuan , Yi Ying-Chen , Chang Jo-Shu , Ng I-Son 
Published: May 2019

AbstractShewanella oneidensisMR-1, a bioelectricity generating bacterium, is broadly used in bioremediation, microbial fuel cell and dissimilatory reduction and recovery of precious metals. Herein, we report for the first time that photo induction as a trigger to stimulate gold nanoparticles (Au@NPs) formation by MR-1, with wavelength and light intensity as two key variables. Results indicated that sigmoidal model is the best fit for Au@NPs formation at various wavelengths (with R2 > 0.97). Light intensity in terms of photosynthetic photon flux density (PPFD) critically influences the rate constant in the low-light intensity region (PPFD < 20), while wavelength controls the maximum rate constant in the high-light region (PPFD > 20). By deletion of Mtr pathway genes in MR-1, we proposed the mechanism for light induced Au@NP formation is the excitation effect of light on certain active groups and extracellular polymeric substances (EPS) on the cell surface. Also, the release of electrons from proteins and co-enzyme complexes enhance electron generation. To the best of our knowledge, this is the first-attempt to explore the effect of photo-induction on Au@NPs production by MR-1, which provides an alternative cost-effective and eco-friendly process in green chemical industry.
Corpse management of the invasive Argentine ant inhibits growth of pathogenic fungi
Authors: Kesäniemi Jenni , Koskimäki Janne J. , Jurvansuu Jaana 
Published: May 2019

AbstractA dead conspecific poses a potential pathogen risk for social animals. We have discovered that Argentine ants (Linepithema humile) prevent spread of pathogenic fungi from corpses by depositing the dead to combined toilet and refuse areas and applying pygidial gland secretion on them. The presence of a corpse in a nest increases this secretion behaviour. We identified three fungi growing on Argentine ant corpses. Growth of the Argentine ant pathogen Aspergillus nomius and the plant pathogen Fusarium solani on corpses was inhibited as long as the ants were constantly attending them as the ant anal secretion only delayed germination of their spores. In contrast, the effect of the ant anal secretion on the human pathogen Aspergillus fumigatus was much stronger: it prevented spore germination and, accordingly, the fungus no longer grew on the treated corpses. The Argentine ants are one of the world’s worst invasive alien species as they cause ecological and economical damage in their new habitats. Our discovery points at a novel method to limit Argentine ant colonies through their natural fungal pathogens.
Extracellular vesicle microRNA quantification from plasma using an integrated microfluidic device
Authors: Ramshani Zeinab , Zhang Chenguang , Richards Katherine , Chen Lulu , Xu Geyang , Stiles Bangyan L. , Hill Reginald , Senapati Satyajyoti , Go David B. , Chang Hsueh-Chia 
Published: May 2019

AbstractExtracellular vesicles (EV) containing microRNAs (miRNAs) have tremendous potential as biomarkers for the early detection of disease. Here, we present a simple and rapid PCR-free integrated microfluidics platform capable of absolute quantification (<10% uncertainty) of both free-floating miRNAs and EV-miRNAs in plasma with 1 pM detection sensitivity. The assay time is only 30 minutes as opposed to 13 h and requires only ~20 μL of sample as oppose to 1 mL for conventional RT-qPCR techniques. The platform integrates a surface acoustic wave (SAW) EV lysing microfluidic chip with a concentration and sensing microfluidic chip incorporating an electrokinetic membrane sensor that is based on non-equilibrium ionic currents. Unlike conventional RT-qPCR methods, this technology does not require EV extraction, RNA purification, reverse transcription, or amplification. This platform can be easily extended for other RNA and DNA targets of interest, thus providing a viable screening tool for early disease diagnosis, prognosis, and monitoring of therapeutic response.
Identifying the murine mammary cell target of metformin exposure
Authors: Shehata Mona , Kim Hyeyeon , Vellanki Ravi , Waterhouse Paul D. , Mahendralingam Mathepan , Casey Alison E. , Koritzinsky Marianne , Khokha Rama 
Published: May 2019

AbstractThe heterogeneity of breast cancer makes current therapies challenging. Metformin, the anti-diabetic drug, has shown promising anti-cancer activities in epidemiological studies and breast cancer models. Yet, how metformin alters the normal adult breast tissue remains elusive. We demonstrate metformin intake at a clinically relevant dose impacts the hormone receptor positive (HR+) luminal cells in the normal murine mammary gland. Metformin decreases total cell number, progenitor capacity and specifically reduces DNA damage in normal HR+ luminal cells, decreases oxygen consumption rate and increases cell cycle length of luminal cells. HR+ luminal cells demonstrate the lowest levels of mitochondrial respiration and capacity to handle oxidative stress compared to the other fractions, suggesting their intrinsic susceptibility to long-term metformin exposure. Uncovering HR+ luminal cells in the normal mammary gland as the major cell target of metformin exposure could identify patients that would most benefit from repurposing this anti-diabetic drug for cancer prevention/therapy purposes.
Substrate geometry modulates self-assembly and collection of plasma polymerized nanoparticles
Authors: Santos Miguel , Reeves Bryce , Michael Praveesuda , Tan Richard , Wise Steven G. , Bilek Marcela M. M. 
Published: May 2019

AbstractPlasma polymerized nanoparticles (PPN) formed in plasma reactors have been considered undesirable in technological applications. More recently however, PPN were proposed as a new class of multifunctional nanocarriers for drug delivery. Therefore, synthesis of PPN requires cost-effective collection strategies that maximize yield and improve reproducibility. This work shows that the collection of PPN in dusty plasmas is modulated by modifying the geometry of substrates from planar to well-shaped collectors. The electric field profile around the wells acts as an electrostatic lens, concentrating nanoparticles and significantly bolstering process yield. The aggregation of PPN is governed by a balance between plasma expansion throughout the wells, inter-particle repulsion, particle size and density. PPN are readily dispersed in aqueous solution yielding monodisperse populations. The use of a disposable well-shape collector provides a cost-effective nanoparticle collection approach that can be adopted in a wide range of plasma polymerization configurations without the need for reactor re-design.
Assessing the Breastfeeding Dyad: A Guide for Speech-Language Pathologists
Authors: Mahurin-Smith Jamie , Genna Catherine Watson 
Published: May 2019

Purpose
More than 80% of U.S. mothers initiate breastfeeding; for many of them, direct breastfeeding is an important goal. Speech-language pathologists (SLPs) who assess infants with feeding concerns, however, are generally much more familiar with assessing bottle-feeding. The purpose of this tutorial is to assist SLPs in building on their existing assessment skills in order to provide effective, evidence-based options for mothers who wish to breastfeed their infants.

Conclusion
SLPs can assist families in meeting their breastfeeding goals through effective assessment of breastfeeding dyads.