bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Cx46 targeting strategy for cancer stem cells
Authors: Mulkearns-Hubert Erin E. , Torre-Healy Luke A. , Silver Daniel J. , Eurich Jennifer T. , Serbinowski Emily , Hitomi Masahiro , Zhou John , Przychodzen Bartlomiej , Zhang Renliang , Sprowls Samuel A. , Hale James S. , Alban Tyler , Berezovsky Artem , Bell Brent A. , Lockman Paul R. , Jha Babal K. , Lathia Justin D. 
Published: March 2018

SummaryGap junction-mediated cell-cell communication enables tumor cells to synchronize the execution of complex processes. Despite the connexin family of gap junction proteins being considered tumor suppressors, we previously found that glioblastoma cancer stem cells (CSCs) express higher levels of Cx46 compared to non-stem tumor cells, and this was necessary and sufficient for CSC maintenance. To develop a Cx46 targeting strategy, we utilized point mutants to disrupt specific functions of Cx46 and found that gap junction coupling was the critical function of Cx46 for CSCs. Based on this finding, we screened a clinically relevant library of small molecules and identified clofazimine as an inhibitor of Cx46-specific cell-cell communication. Clofazimine attenuated proliferation, self-renewal, and tumor growth and synergized with temozolomide to induce apoptosis. These data suggest that combining clofazimine with standard-of-care therapies may target glioblastoma CSCs. Furthermore, these results demonstrate the importance of targeting cell-cell communication as an anti-cancer therapy.
Diverse lipid conjugates for functional extra-hepatic siRNA deliveryin vivo
Authors: Biscans Annabelle , Coles Andrew , Haraszti Reka , Echeverria Dimas , Hassler Matthew , Osborn Maire , Khvorova Anastasia 
Published: March 2018

AbstractRNAi-based therapeutics show promising clinical data for treatment of liver-associated disorders. However, siRNA delivery into extra-hepatic tissues remains an obstacle, limiting the use of siRNA-based therapies. Here we report on a first example of chemical engineering of lipophilic conjugates to enable extra-hepatic delivery. We synthesized a panel of fifteen lipophilic siRNA and evaluated the impact of their chemical configuration on siRNA tissue distribution profile. Generally, lipophilic conjugates allow siRNA distribution to a wide range of tissues, where the degree of lipophilicity defines the ratio of liver/spleen to kidney distribution. In addition to primary clearance tissues, several conjugates achieve significant siRNA distribution to lung, heart, adrenal glands, fat, muscle. siRNA tissue accumulation leads to productive silencing, shown with two independent targets. siRNA concentrations necessary for productive silencing are tissue and conjugate dependent, varying significantly from 5 to 200 ng/mg. The collection of conjugated siRNA described here enables functional gene modulationin vivoin lung, muscle, fat, heart, adrenal glands opening these tissues for future therapeutic intervention.
Online restaurant entrepreneurship: the story of Holachef in an increasingly digitalized India
Authors: Jha Sumi , Sekhar Bhattacharyya Som 
Published: March 2018

Subject area
This case can be used in courses on strategic management for second year masters’ level management students (with a focus on strategic analysis of internet-based business models in India) and entrepreneurship (with a focus on business growth). The primary focus of the case is how an internet-based business model in the food industry took shape.

Study level/applicability
The case enumerates how strategic analysis can be performed to analyze the firm based on topics such as the analysis of the mission and vision of Holachef based on the Ashridge mission model, examining strategy with Mintzberg’s 5Ps of strategy, performing a PESTLE analysis of HolaChef, evaluating Holachef with Porter’s industry analysis, performing Value net analysis for Holachef, examining Holachef’s business with strategy group analysis, examining the roots of core competencies of Holachef and explaining Holachef’s resource and capabilities with the valuable, rare, inimitable, non-substitutable (VRIN) Framework.

Case overview
Saurabh Saxena and Anil Gelra co-founded Holachef, “a restaurant in cloud” in March 2014. In a city like Mumbai, there are many households where both partners work; this had led to difficulties for people finding time to prepare food at home. Holachef is an online delivery platform which aggregates chefs for home-like multiple cuisine preparation. Holachef’s vision is to satisfy the need for homemade healthy food. The three pillars of Holachef to provide such food are technology (orders are taken through a website, mobile application and phone calls), food (enlisted chefs on the website) and logistics. The food prepared by chefs is assembled at different distribution centres and routed to customers. The efficient logistics and storage system maintain the quality of food. These pillars help Holachef to serve customers with efficiency at affordable prices.

Expected learning outcomes
Performing strategic analysis from both an industrial organization theory and resource-based view (RBV) perspective with VRIN framework. This is in the context of online business models in a digitizing India. Entrepreneurial strategy concepts and challenges faced by entrepreneurs in an online business.

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 11: Strategy.
Antecedents of entrepreneurial intentions among students in vocational training programmes
Authors: Galvão Anderson , Marques Carla Susana , Marques Carlos Peixeira 
Published: March 2018

Purpose
The purpose of this paper is to contribute to research on individual entrepreneurial intention (IEI) by assessing the importance of entrepreneurship education to students in vocational training programmes and using the theory of planned behaviour (TPB) to analyse these students’ entrepreneurial intentions. The family background of the students and their exposure to entrepreneurship subject matter were included as antecedents of TPB components and IEI.

Design/methodology/approach
To test the research model, the primary data were collected with questionnaires distributed to students in their last year of vocational training programmes with and without entrepreneurship coursework, in a region of Northern Portugal. The data were analysed using structural equation modelling.

Findings
The results show that TPB dimensions substantially contribute to explaining students’ IEI. However, their family background makes only a minor contribution, and exposure to entrepreneurship education has no influence on IEI.

Research limitations/implications
Given these results, the authors propose a broader discussion is needed of the importance of introducing business classes into the curricula of vocational training programmes.

Originality/value
This research’s results show that IEI models need to assign greater importance to variables related to previous exposure to entrepreneurial experiences through direct family members. The findings contribute to a fuller understanding of IEI and the factors that precede the formation of this intention among students in training programmes.
Analysis of skill gap for business graduates: managerial perspective from banking industry
Authors: Abbasi Farhad Khurshid , Ali Amjad , Bibi Naila 
Published: March 2018

Purpose
The purpose of this paper is to identify the gap between skills expected by managers and skills possessed by business graduates employed by banking industry.

Design/methodology/approach
A questionnaire-based survey was conducted with bank officers under whom fresh business graduates were working. They were asked to indicate the importance of 12 employability skills in the industry and to rate business graduates working under them against these skills. Results are achieved by applying paired samples and independent samples t-tests on data collected from 121 bank officers.

Findings
Results prove that overall employability skills of the graduates are lesser than expected by the managers. Significant skill gaps were found for listening, problem solving, communication, leadership, interpersonal, analytical, self-management, numeracy and critical thinking. Results also reveal that problem-solving skill of male graduates is superior that that of females.

Practical implications
The study makes business graduates clear in what skills they are to learn and how it relates to the expectations of managers in banking industry. It helps business schools to revise and improve curriculum of some specialized banking programs according to the needs of the industry.

Originality/value
This is the first study that investigates the skills required by the banking industry out of business graduates. It also identifies the skill gaps for fresh business graduates from managerial perspective in banking industry of Pakistan.
Development of insect repellent finish by a simple coacervation microencapsulation technique
Authors: Sharma Rachna , Goel Alka 
Published: March 2018

PurposeThe paper focused onto the development of microcapsules by using two essential oils. It proposes the uses of eucalyptus oil and cedarwood oil as a natural insecticide. The purpose of this paper is to demonstrate the application of developed microcapsules to impart insect repellency on textile substrate.Design/methodology/approachThe paper opted for an experimental study using two essential oils and gum in formations of microcapsules through a simple coaseravtion encapsulation technique. The developed solution was analyzed, including confirmation of size and structure through. Application of developed finish on substrate was also undertaken to prove better ability as repellent fabric.FindingsThe paper highlights useful invention of microencapsulated fabric developed with the combination of gum acacia and eucalyptus oil as core and shell material. The developed fabric has better ability to repel silverfish as compared to microencapsulated fabric developed with gum acacia (shell) and cedarwood oil (core).Research limitations/implicationsDue to the lack of time and less availability of essential oils, only two oils were used to test the insect repellent behavior.Practical implicationsThis paper fulfills an identified need, it includes implications for the development of a very useful natural insecticide to repel silverfish (Lepisma saccharina) insect. This insect is a very common problem found in cloth wardrobes and bookshelves; it mainly attacks the fabric with cellulosic content and starch.Social implicationsSociety will get major benefit of using these microencapsulated finished fabrics, which repel silverfish from their home and keep their clothing and books safe for longer period. The natural fragrance and medicinal benefits of these essential oils can never be ignored.Originality/valueThis study sets a new approach to repel insects like silverfish from the bookshelves and clothing wardrobes. A layer of insect repellent microencapsulated finished fabric can be added in these shelves and wardrobes. It is an eco-friendly approach of using natural essential oils instead of chemical insecticides.
Using international sport events as part of a brand construction strategy
Authors: Puente-Díaz Rogelio 
Published: March 2018

Purpose
The purpose of this paper is twofold. First, the author examines how the destination brand Mexico is using international sporting events as part of its branding strategy to deal with the challenges faced by destinations and to overcome some of its weaknesses. Second, the author assesses the positive and negative consequences of such strategy. The investigation tries to fill a gap in terms of understanding and assessing opportunities and challenges experienced by the sport industry in emerging markets.

Design/methodology/approach
The author used a case study research strategy, relying on documentation, archival records, and personal interviews with experts as sources of evidence. Given that most research efforts have focused on developed countries, this research approach was exploratory and descriptive.

Findings
The thematic analysis revealed the presence of five major themes related to the process of hosting and using Formula One (F1), National Football League (NFL), Major League Baseball (MLB), and National Basketball Association (NBA) games as part of a brand strategy. These five major themes were labeled: brand strategy challenges and opportunities, balancing short- and long-term goals and benefits, tension between stakeholders from different destinations, social issues, and areas of improvement.

Originality/value
The findings shed light on the challenges and opportunities that hosting international sport events bring to a destination brand with an emerging economy such as Mexico. The opportunity to host these types of events comes from the expansion strategies of well-known sport brands such as F1, NFL, MLB, and NBA.
Financial inclusion: perceptions of visually impaired older Nigerians
Authors: Okonji Patrick Emeka , Ogwezzy Darlington Chukwunalu 
Published: March 2018

PurposeThe purpose of this paper is to explore areas of challenge in managing personal finances among visually impaired older people, with critical appraisal of current structures available in financial institutions for equal access to financial services. The paper intends to create understanding of the drawbacks to financial inclusion from the perspectives and experiences of older people with vision impairment in Nigeria as well as highlighting areas where support is/are needed to tackle digital exclusion.Design/methodology/approachThis study employed a qualitative approach, interviewing 30 visually impaired older adults, aged 60 years and over. Participants were drawn from a voluntary organisation for people living with vision impairment in Southwest Nigeria. Interview data were transcribed verbatim and analysed thematically using qualitative data analysis software – NVivo (version 11).FindingsResults provide clear insight on the nature of the challenges faced by visually impaired older people, particularly with managing finances on computer-enabled platforms. The findings also revealed fears and hopes of this group about the rapid evolution of technologies for managing finances.Originality/valueThe study critically explored an understudied population, showing peculiar challenges and made a case for inclusive designs that are useful for digital inclusion of this population.
Population health management guiding principles to stimulate collaboration and improve pharmaceutical care
Authors: Steenkamer Betty , Baan Caroline , Putters Kim , van Oers Hans , Drewes Hanneke 
Published: March 2018

Purpose
A range of strategies to improve pharmaceutical care has been implemented by population health management (PHM) initiatives. However, which strategies generate the desired outcomes is largely unknown. The purpose of this paper is to identify guiding principles underlying collaborative strategies to improve pharmaceutical care and the contextual factors and mechanisms through which these principles operate.

Design/methodology/approach
The evaluation was informed by a realist methodology examining the links between PHM strategies, their outcomes and the contexts and mechanisms by which these strategies operate. Guiding principles were identified by grouping context-specific strategies with specific outcomes.

Findings
In total, ten guiding principles were identified: create agreement and commitment based on a long-term vision; foster cooperation and representation at the board level; use layered governance structures; create awareness at all levels; enable interpersonal links at all levels; create learning environments; organize shared responsibility; adjust financial strategies to market contexts; organize mutual gains; and align regional agreements with national policies and regulations. Contextual factors such as shared savings influenced the effectiveness of the guiding principles. Mechanisms by which these guiding principles operate were, for instance, fostering trust and creating a shared sense of the problem.

Practical implications
The guiding principles highlight how collaboration can be stimulated to improve pharmaceutical care while taking into account local constraints and possibilities. The interdependency of these principles necessitates effectuating them together in order to realize the best possible improvements and outcomes.

Originality/value
This is the first study using a realist approach to understand the guiding principles underlying collaboration to improve pharmaceutical care.
Management simulations for Lean healthcare: exploiting the potentials of role-playing
Authors: Barnabè Federico , Giorgino Maria Cleofe , Guercini Jacopo , Bianciardi Caterina , Mezzatesta Vincenzo 
Published: March 2018

Purpose
The purpose of this paper is to investigate the potentials of role-playing (RP) both in training healthcare (HC) professionals to implement tools and improvement actions based on Lean principles, and in supporting group discussion and the sharing of different competencies for the development of Lean HC.

Design/methodology/approach
The paper presents the case study of an RP simulation called LEAN HEALTHCARE LAB, which is used to train HC professionals at Siena University Hospital. The paper reports and discusses the results of a specific two-day simulation session and of a questionnaire that was distributed to gather feedback from the participants.

Findings
The paper verifies the potentials of RP to be a powerful educational and training tool that is able to stimulate the HC participants to apply Lean thinking principles and share their competencies in collaborative decision-making processes.

Research limitations/implications
The study provides data in reference to one single simulation session, although the game has already been applied several times in different HC organizations with very similar outcomes. Moreover, a more in-depth analysis of players’ perceptions and decisions could be performed using different tools in addition to the adopted questionnaire.

Practical implications
RP games (RPGs) are effective training and educational tools for HC professionals. They offer benefits and learning conditions which are definitely different if compared with more conventional education programs for HC professionals.

Originality/value
While previous studies have extensively discussed the potentialities of RPG and simulations in training programs, only a few articles have discussed the RP adoption for Lean thinking and even less to educate HC professionals on Lean principles and tools.
Numerical analysis on circular concrete-filled tubular columns subjected to fire
Authors: Pires Tiago A. de C. , Rodrigues João Paulo C. , Silva Jose J.R. 
Published: March 2018

PurposeNowadays, circular concrete-filled tubular (CFT) columns are largely used in construction because of structural and architectural advantages such as high load bearing capacity and aesthetic appearance. The behavior of CFT columns at ambient and high temperatures is good; however, there are problems related to their behavior in fire when inserted in a real building structure, as for example, the influence of the restraining to thermal elongation that have to be addressed in order to improve their design. This study aims to present the results of a numerical study on the behavior of CFT columns with restrained thermal elongation in case of fire.Design/methodology/approachThe parameters tested in the numerical simulations included column slenderness, load level, surrounding structure stiffness and steel reinforcement ratio. A sequentially coupled thermal stress analysis was carried out. The numerical model was validated with results from a large series of fire resistance tests carried out at Coimbra University, in Portugal. From these, simple equations to evaluate CFT column critical times were derived.FindingsThe results were also compared with the ones obtained from the current EN 1994-1-2:2005 simplified calculation and tabulated data methods. For the analyzed cases, it was verified that, while the simplified calculation method led to safe results on the evaluation of the fire resistance of CFT columns with restrained thermal elongation, the tabulated data method led, in certain cases, to unsafe results. This research showed also lower critical times than those from literature on similar type of columns.Originality/valueThe influence of the stiffness of the surrounding structure on the behavior of CFT columns subjected to fire was not yet clear in the major part of the studies already carried out. So, this paper has the originality to consider this parameter in the numerical simulations of this type of columns.
Mechanism between perceived organizational support and transfer of training
Authors: Islam Talat , Ahmed Ishfaq 
Published: March 2018

PurposeThis study aims to investigate the mechanism between perceived organizational support and transfer of training using self-efficacy and job satisfaction as mediating variables. More specifically, self-efficacy is examined as a mediator between perceived organizational support and job satisfaction, whereas job satisfaction is examined as a mediator between perceived organizational support and transfer of training.Design/methodology/approachThis quantitative study is based on data collected from 409 employees of the banking sector on a random basis.FindingsStructural equation modeling analysis confirmed the mediating role of job satisfaction between perceived organizational support and transfer of training. In addition, self-efficacy was found to perform the mediating role between perceived organizational support and job satisfaction.Research limitations/implicationsThe data for this study were collected at one point of time, and it has implications for organizations and employees.Originality/valueThis study highlights the emerging issue of transfer of training and gives a practical model to the organizations to strengthen their human resources. This study is perhaps the first attempt to empirically investigate the mediating role of self-efficacy and job satisfaction.
Exploring antecedents of social media usage in B2B: a systematic review
Authors: Pascucci Federica , Ancillai Chiara , Cardinali Silvio 
Published: March 2018

Purpose
This paper aims to review the state-of-the-art literature on social media adoption in business-to-business (B2B) contexts to propose an inclusive and theoretical viewpoint to understand the antecedents of this phenomenon.

Design/methodology/approach
This paper presents the results of a systematic literature review. For this purpose, 29 studies published in academic journals, books and conference papers in the field of marketing and management from 2001 to 2017 were analysed.

Findings
The results show that the number of studies has increased in the past five years. Three different groups of antecedents are identified by considering the nature of these factors (personal, organisational and external) and analysed at two different levels of adoption: individual and firm/function. Managerial implications and future research insights are provided.

Research limitations/implications
This research area deserves much more attention, both theoretical and empirical, to analyse the existing classifications and develop new categories of antecedents of social media adoption in B2B. Further studies are needed on the individual level of adoption, on new skills and capabilities required to use social media as well as on the social factors influencing usage.

Practical implications
The literature review allows to understand the role of personal, organisational and social antecedents and suggest ways to improve the level and quality of adoption.

Originality/value
Despite a considerable interest in research on social media, this paper provides the first complete framework in the new field of study concerning social media adoption in B2B.