bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Novel Autoantibodies Associated With Psoriatic Arthritis
Authors: Yuan Yulin , Qiu Jingyi , Lin Zuan‐Tao , Li Wen , Haley Christopher , Mui Uyen Ngoc , Ning Jing , Tyring Stephen K. , Wu Tianfu 
Published: January 2019

ObjectiveThe autoimmune etiology in psoriasis remains to be clarified. We therefore undertook this study to identify novel pathogenic autoantigens and autoantibodies in patients with psoriasis, with the aim of shedding light on the molecular and cellular basis of the pathogenesis of psoriasis and psoriatic arthritis (PsA).MethodsIn this study, we developed an autoantigen array system that harbors a variety of antigens, including typical autoantigens in rheumatic diseases as well as skin antigens, inflammatory mediators, and putative autoantigens in psoriasis. Serum samples from patients with psoriasis (n = 73) were used to interrogate the antigens on the array. In addition, enzyme‐linked immunosorbent assays of individual autoantibodies were used in validation studies.ResultsLevels of several autoantibodies were found to be elevated in the serum of patients with psoriasis compared to healthy controls; in particular, IgG autoantibodies against 2 novel antigens,LL‐37 andADAMTS‐L5, were significantly increased in patients with psoriasis. Importantly, serum levels of IgG autoantibodies againstLL‐37 andADAMTS‐L5 were correlated with the Psoriasis Area and Severity Index, and reflected disease progression in longitudinally collected serum samples from patients with psoriasis. Importantly, both anti–ADAMTS‐L5 and anti–LL‐37 autoantibody levels were also significantly elevated in psoriasis patients with PsA compared to those without PsA, suggesting that these molecules may be involved in the pathogenesis of PsA.ConclusionOur findings indicate that these identified autoantibodies may be useful biomarkers and may serve as therapeutic targets in psoriasis and PsA.
Command filtered path tracking control of saturated ASVs based on time‐varying disturbance observer
Authors: Gao Zhenyu , Guo Ge 
Published: January 2019

AbstractThis paper investigates the path‐tracking control problem for an autonomous surface vessel (ASV) with unknown time‐varying disturbances and input saturation. A robust nonlinear control law is proposed based on a disturbance observer and an auxiliary system in the context of command filtered control. The disturbance observer is constructed to estimate the unknown time‐varying disturbances, the auxiliary dynamic system is employed to handle input saturation, and the compensator based command filtered control technique makes the designed path‐tracking control law simple and easy to implement in practice. It is proved that the nonlinear control law can track the desired vessel's position and heading, while guaranteeing the uniform ultimate boundedness of all signals in the path‐tracking control system. Simulation results further demonstrate the effectiveness of the method.
Fault diagnosis based on sliding mode observer for LPV descriptor systems
Authors: Hamdi Habib , Rodrigues Mickael , Mechmeche Chokri , Benhadj Braiek Naceur 
Published: January 2019

AbstractThis paper considers the problem of fault detection and reconstruction of actuator faults for linear parameter varying descriptor systems. A polytopic sliding mode observer (PSMO) is constructed to achieve simultaneous reconstruction of LPV polytopic descriptor system states and actuator faults. Sufficient conditions for the existence and design algorithm of the proposed polytopic sliding mode observer are provided. In addition, the design of the PSMO is formulated in terms of linear matrix inequalities that can be suitably solved using convex optimization techniques. This PSMO can force the output estimation error to converge to zero in a finite time when the actuators faults are bounded through the reinjection of the output estimation error via a nonlinear switching term. The effectiveness of the design technique is illustrated through a simulation of an anaerobic bioreactor.
Outcomes of infants born to women with influenza A(H1N1)pdm09
Authors: Newsome Kim , Alverson C. J. , Williams Jennifer , McIntyre Anne F. , Fine Anne D. , Wasserman Cathy , Lofy Kathryn H. , Acosta Meileen , Louie Janice K. , Jones‐Vessey Kathleen , Stanfield Valoree , Yeung Alice , Rasmussen Sonja A. 
Published: January 2019

BackgroundPregnant women with influenza are more likely to have complications, but information on infant outcomes is limited.MethodsFive state/local health departments collected data on outcomes of infants born to pregnant women with 2009 H1N1 influenza reported to the Centers for Disease Control and Prevention from April to December 2009. Collaborating sites linked information on pregnant women with confirmed 2009 H1N1 influenza, many who were severely ill, to their infants' birth certificates. Collaborators also collected birth certificate data from two comparison groups that were matched with H1N1‐affected pregnancies on month of conception, sex, and county of residence.Results490 pregnant women with influenza, 1,451 women without reported influenza with pregnancies in the same year, and 1,446 pregnant women without reported influenza with prior year pregnancies were included. Women with 2009 H1N1 influenza admitted to an intensive care unit (ICU; n = 64) were more likely to deliver preterm infants (<37 weeks), low birth weight infants, and infants with Apgar scores <=6 at 5 min than women in comparison groups (adjusted relative risk, aRR = 3.9 [2.7, 5.6], aRR = 4.6 [2.9, 7.5], and aRR = 8.7 [3.6, 21.2], for same year comparisons, respectively). Women with influenza who were not hospitalized and hospitalized women not admitted to the ICU did not have significantly elevated risks for adverse infant outcomes.ConclusionsSeverely ill women with 2009 H1N1 influenza during pregnancy were more likely to have adverse birth outcomes than women without influenza, providing more support for influenza vaccination during pregnancy.
Allele‐Specific Inhibition of Histone Demethylases
Authors: Wagner Shana , Waldman Megan , Arora Simran , Wang Sinan , Scott Valerie , Islam Kabirul 
Published: January 2019

AbstractHistone demethylases play a critical role in mammalian gene expression by removing methyl groups from lysine residues in degree‐ and site‐specific manner. To specifically interrogate members and isoforms of this class of enzymes, we have developed demethylase variants with an expanded active site. The mutant enzymes are capable of performing lysine demethylation with wild‐type proficiency, but are sensitive to inhibition by cofactor‐competitive molecules embellished with a complementary steric “bump”. The selected inhibitors show more than 20‐fold selectivity over the wild‐type demethylase, thus overcoming issues typical to pharmacological and genetic approaches. The mutant–inhibitor pairs are shown to act on a physiologically relevant full‐length substrate. By engineering a conserved amino acid to achieve member‐specific perturbation, this study provides a general approach for studying histone demethylases in diverse cellular processes.
Insight into the Structure and Activity of Surface‐Engineered Lipase Biofluids
Authors: Zhou Ye , Jones Nykola C. , Nedergaard Pedersen Jannik , Pérez Bianca , Vrønning Hoffmann Søren , Vang Petersen Steen , Skov Pedersen Jan , Perriman Adam , Kristensen Peter , Gao Renjun , Guo Zheng 
Published: January 2019

AbstractDespite a successful application of solvent‐free liquid protein (biofluids) concept to a number of commercial enzymes, the technical advantages of enzyme biofluids as hyperthermal stable biocatalysts cannot be fully utilized as up to 90–99% of native activities are lost when enzymes were made into biofluids. With a two‐step strategy (site‐directed mutagenesis and synthesis of variant biofluids) on Bacillus subtilis lipase A (BsLA), we elucidated a strong dependency of structure and activity on the number and distribution of polymer surfactant binding sites on BsLA surface. Here, it is demonstrated that improved BsLA variants can be engineered via site‐mutagenesis by a rational design, either with enhanced activity in aqueous solution in native form, or with improved physical property and increased activity in solvent‐free system in the form of a protein liquid. This work answered some fundamental questions about the surface characteristics for construction of biofluids, useful for identifying new strategies for developing advantageous biocatalysts.
Posterior polar annular choroidal dystrophy association with cystoid macular edema
Authors: Del Valle‐Nava Fernando , Sánchez‐Ramos Jorge , Hernández‐Vázquez Angeles , Gonzalez‐Saldivar Gerardo , Ramirez‐Estudillo Abel 
Published: January 2019

Key Clinical MessagePosterior polar annular choroidal dystrophy (PPACD) is an uncommon retinal dystrophy causing nyctalopia. PPACD has been characteristically described as a foveal sparing dystrophy. We report the first case with cystoid macular edema association.
Incisional hernia repair with plication and utilization of Botox injections: First case report from Saudi Arabia for a 19‐year‐old female
Authors: Hijji Talal , AlShammari Abdullah , AlHammad Alanoud , AlKhalefah Ghadah , Hashem Fuad , Almomen Salha , Aburahmah Mohammad 
Published: January 2019

Key Clinical Message
This article reports on the use of Botox preoperatively for the treatment of a complex ventral hernia which would have typically been treated with component separation technique. The case demonstrates that using the recently developed technique can aid in performing a tension‐free hernia repair with potentially lower complication and recurrence rates.
Redox‐Reversible 2D Metal–Organic Framework Nanosheets (MONs) Based on the Hydroquinone/Quinone Couple
Authors: Maka Vijay Kumar , Mukhopadhyay Arindam , Jindal Swati , Moorthy Jarugu Narasimha 
Published: January 2019

Abstract2D metal–organic nanosheets (MONs), akin to graphene, have aroused immense contemporary interest. In our quest to develop functional 2D MONs based on organic linkers designed de novo, we reasoned that benzene‐tetrabenzoic acid, which has been exploited tremendously in the construction of pillared metal–organic frameworks (MOFs), could be maneuvered readily to access redox‐active MONs based on the benzoquinone/hydroquinone redox couple. Herein, we show that the self‐assembly of 2,3,5,6‐tetrakis(p‐carboxyphenyl)hydroquinone H4BTA with Zn(NO3)2 does lead to 2D metal–organic nanosheets that stack down the y axis, affording a layered Zn MOF. Although the crystals of the latter do not exhibit a discernible chemically induced redox switching behavior, the 2D MONs accessed by ultrasound‐induced liquid‐phase exfoliation (UILPE) lend themselves to a facile redox switching behavior. Treatment of a dispersion of the 2D MONs in methanol with phenyliodine(III) diacetate (PIDA) results in the oxidation of the hydroquinone core to benzoquinone. Remarkably, the latter can be reverted to the former by treatment with ascorbic acid as a reducing agent; indeed, the redox process can be made out by the naked eye. The results constitute the first example of chemically induced redox switching of 2D MONs. In view of emergent applications of 2D materials in general and MONs in particular, for example, improvement of the performance of membranes in separations by doping with MONs, the redox‐switchable property may lead to the development of unique materials with heretofore unexplored potential.
Guest‐Selective Recognition in a Flexible Bipyridinium‐Based Framework in a Reversible Crystal‐to‐Crystal Fashion
Authors: Tan Bin , Yang Xiao‐Dong , Sun Li , Huang Xiao‐Ying , Zhang Jie 
Published: January 2019

AbstractA flexible bipyridinium‐linker‐based porous host framework with electron‐accepting pore surface, namely, [Zn2(L)(pmc)1.5]⋅12 H2O (1; L⋅Cl2=1,1′‐[1,4‐phenylene‐bis(methylene)]bis(4,4′‐bipyridinium) dichloride, H4pmc=pyromellitic acid) exhibits recognition of phenol and aromatic amine guests based on adsorbent–adsorbate charge‐transfer interactions. Significantly, the resultant guest‐encapsulated complexes 1@Guests can all be characterized by single‐crystal X‐ray diffraction. The host framework undergoes a reversible single crystal‐to‐single crystal transformation in response to the inclusion of different guests with flexible torsional motions of the hexagonal ring and the trapezoid‐shaped bipyridinium groups. Such recognition can be visibly monitored and detected by obvious color changes. The host framework could also be recovered, and this suggested that guest sorption/desorption is reversible and that the host framework could be reused in potential applications. This work may provide an effective way to develop porous materials with special emphasis on applications involving guest recognition.
Regulating Charge‐Transfer in Conjugated Microporous Polymers for Photocatalytic Hydrogen Evolution
Authors: Mothika Venkata Suresh , Sutar Papri , Verma Parul , Das Shubhajit , Pati Swapan K. , Maji Tapas Kumar 
Published: January 2019

AbstractBandgap engineering in donor–acceptor conjugated microporous polymers (CMPs) is a potential way to increase the solar‐energy harvesting towards photochemical water splitting. Here, the design and synthesis of a series of donor–acceptor CMPs [tetraphenylethylene (TPE) and 9‐fluorenone (F) as the donor and the acceptor, respectively], F0.1CMP, F0.5CMP, and F2.0CMP, are reported. These CMPs exhibited tunable bandgaps and photocatalytic hydrogen evolution from water. The donor–acceptor CMPs exhibited also intramolecular charge‐transfer (ICT) absorption in the visible region (λmax=480 nm) and their bandgap was finely tuned from 2.8 to 2.1 eV by increasing the 9‐fluorenone content. Interestingly, they also showed emissions in the 540–580 nm range assisted by the energy transfer from the other TPE segments (not involved in charge‐transfer interactions), as evidenced from fluorescence lifetime decay analysis. By increasing the 9‐fluorenone content the emission color of the polymer was also tuned from green to red. Photocatalytic activities of the donor–acceptor CMPs (F0.1CMP, F0.5CMP, and F2.0CMP) are greatly enhanced compared to the 9‐fluorenone free polymer (F0.0CMP), which is essentially due to improved visible‐light absorption and low bandgap of donor–acceptor CMPs. Among all the polymers F0.5CMP with an optimum bandgap (2.3 eV) showed the highest H2 evolution under visible‐light irradiation. Moreover, all polymers showed excellent dispersibility in organic solvents and easy coated on the solid substrates.
Fullerene‐Filled Stilbene Stars: The Balance between Isolated C60 Helices and 3D Networks in Liquid‐Crystal Self‐Assemblies
Authors: Hügel Markus , Dechant Moritz , Scheuring Nikolai , Ghosh Tapas , Lehmann Matthias 
Published: January 2019

AbstractA series of shape‐persistent star‐shaped oligo(phenylene vinylene) liquid crystals and derivatives with fullerene tethered through spacers of different lengths to one arm were successfully synthesized. Solution studies by NMR, UV/Vis and fluorescence spectroscopy revealed the preferential location of the C60 acceptor in the vicinity of the peripheral donor unit, which affects the quenching of the emission of the conjugated stilbenoid scaffold in the donor–acceptor dyad. The fluorescence was completely absent in the liquid crystal phase due to the extraordinary hierarchical self‐assembly. In this family of mesogens, the intrinsic free space has to be filled either by an extremely tight packing of the stars or by the fullerenes as guests. The spacer lengths control the nanosegregation of the C60 units in the cavities of the stars in either independent triple helices or unprecedented 3D networks, in which fullerenes are positioned at the interface of neighboring columns. Eventually, the clearing temperature of such large complex donor–acceptor systems can be tuned by an entropy effect defined by the length of the spacer. The accessibility of the isotropic phase without decomposition is an important prerequisite for future alignment studies associated with potential material applications in organic electronics.
Dendrimeric Nanoparticles for Two‐Photon Photodynamic Therapy and Imaging: Synthesis, Photophysical Properties, Innocuousness in Daylight and Cytotoxicity under Two‐Photon Irradiation in the NIR
Authors: Sourdon Aude , Gary‐Bobo Magali , Maynadier Marie , Garcia Marcel , Majoral Jean‐Pierre , Caminade Anne‐Marie , Mongin Olivier , Blanchard‐Desce Mireille 
Published: January 2019

AbstractThe synthesis and the photophysical properties of a new class of fully organic monodisperse nanoparticles for combined two‐photon imaging and photodynamic therapy are described. The design of such nanoparticles is based on the covalent immobilization of a dedicated quadrupolar dye that combines excellent two‐photon absorbing (2PA) properties, fluorescence and singlet oxygen generation ability, in a phosphorous‐based dendrimeric architecture. First, a bifunctional quadrupolar dye bearing two different grafting moieties, a phenol function and an aldehyde function, was synthesized. It was then covalently grafted through its phenol function to a phosphorus‐based dendrimer scaffold of generation 1. The remaining aldehyde functions were then used to continue the dendrimer synthesis up to generation 2, introducing finally 24 water‐solubilizing triethyleneglycol chains at its periphery. A dendrimer confining 12 photoactive quadrupolar units in its inner scaffold and showing water solubility was thus obtained. Interestingly, the G1 and G2 dendrimers retain some fluorescence as well as significant singlet oxygen production efficiencies while they were found to show very high 2PA cross‐sections in a broad range of the NIR biological spectral window. Hydrophilic dendrimer G2 was tested in vitro on breast cancer cells, first in one‐ and two‐photon microscopy, which allowed for visualization of their cell internalization, then in two‐photon photodynamic therapy. While being nontoxic in the dark and, more importantly, under exposure to daylight, dendrimer G2 proved to be a very efficient cell‐death inducer only under two‐photon irradiation in the NIR.
A New Biscarbazole‐Based Metal–Organic Framework for Efficient Host–Guest Energy Transfer
Authors: Mu Qianqian , Liu Jingjuan , Chen Weiben , Song Xiaoyu , Liu Xiaoting , Zhang Xiaotao , Chang Ze , Chen Long 
Published: January 2019

AbstractA new metal–organic framework (MOF), [Zn6L4(Me2NH2+)4⋅3 H2O] (1) was constructed based on [9, 9′‐biscarbazole]‐3, 3′, 6, 6′‐tetracarboxylic acid (H4L) and Zn2+ ions. The porous framework and intense blue fluorescence of the MOF based on the biscarbazole moiety of the ligand could facilitate efficient host to guest energy transfer, which makes it an ideal platform for the tuning of luminescence.
Development, Scope, and Applications of Titanium(III)‐Catalyzed Cyclizations to Aminated N‐Heterocycles
Authors: Leijendekker Leonardus H. , Weweler Jens , Leuther Tobias M. , Kratzert Daniel , Streuff Jan 
Published: January 2019

AbstractThe exceptionally mild conditions of a titanium(III)‐catalyzed cyclization reaction paired with a convenient acid/base extraction have enabled the straightforward synthesis, isolation, and direct N‐functionalization of amino heterocycles such as 3‐aminoindoles and ‐pyrroles. The unprotected heterocycles are ideal building blocks for the installation of aminated indoles and pyrroles into target molecules, but their sensitivity has previously impeded their synthesis by modern catalytic methods. This full paper presents the development and extended scope of the new cyclization methodology. The transformation of the products into fused bis‐indoles is also demonstrated along with the discovery of an unusual palladium‐catalyzed reductive biphenyl coupling reaction. The titanium(III)‐catalyzed cyclization has also been applied to the synthesis of substituted 3‐iminoindolines, which are of potential interest for applications in natural product synthesis and exhibit tunable blue‐to‐green fluorescence properties.
Iodide Discrimination by Tetra‐Iodotriazole Halogen Bonding Interlocked Hosts
Authors: Klein Harry A. , Beer Paul D. 
Published: January 2019

AbstractWhilst the exploitation of interlocked host frameworks for anion recognition is widely established, examples incorporating halogen bond donor groups are still relatively rare. Through the integration of a novel tetra(iodotriazole)‐pyridinium motif into macrocycle and axle components, a family of halogen bonding catenane and rotaxanes are constructed for anion recognition studies in a competitive aqueous‐organic solvent mixture. Importantly, the degree of anion selectivity displayed is dictated by the topological nature and charged state of the respective interlocked host cavity. All the interlocked hosts exhibit iodide anion selectivity over other halides and sulfate, with the level of discrimination being the greatest with the mono‐cationic rotaxane. Arising from greater electrostatic interactions working in tandem with halogen bonding and hydrogen bonding, the di‐cationic rotaxane displays stronger anion association at the expense of a relatively lower degree of iodide selectivity.
Cellular Target of a Rhodium Metalloinsertor is the DNA Base Pair Mismatch
Authors: Boyle Kelsey M. , Nano Adela , Day Catherine , Barton Jacqueline K. 
Published: January 2019

AbstractDefects in DNA mismatch repair (MMR) are commonly found in various cancers, especially in colorectal cancers. Despite the high prevalence of MMR‐deficient cancers, mismatch‐targeted therapeutics are limited and diagnostic tools are indirect. Here, we examine the cytotoxic properties of a rhodium metalloinsertor, [Rh(phen)(chrysi)(PPO)]2+ (RhPPO) in 27 diverse colorectal cancer cell lines. Despite the low frequency of genomic mismatches and the non‐covalent nature of the RhPPO‐DNA lesion, RhPPO is on average five times more potent than cisplatin. Importantly, the biological target and profile for RhPPO differs from that of cisplatin. A fluorescent metalloinsertor, RhCy3, was used to demonstrate that the cellular target of RhPPO is the DNA mismatch. RhCy3 represents a direct probe for MMR‐deficiency and correlates directly with the cytotoxicity of RhPPO across different cell lines. Overall, our studies clearly indicate that RhPPO and RhCy3 are promising anticancer and diagnostic probes for MMR‐deficient cancers, respectively.
Digitalization in Thermodynamics
Authors: Forte Esther , Jirasek Fabian , Bortz Michael , Burger Jakob , Vrabec Jadran , Hasse Hans 
Published: January 2019

AbstractDigitalization is about data and how they are used. This has always been a key topic in applied thermodynamics. In the present work, the influence of the current wave of digitalization on thermodynamics is analyzed. Thermodynamic modeling and simulation is changing as large amounts of data of different nature and quality become easily available. The power and complexity of thermodynamic models and simulation techniques is rapidly increasing, and new routes become viable to link them to the data. Machine learning opens new perspectives, when it is suitably combined with classical thermodynamic theory. Illustrated by examples, different aspects of digitalization in thermodynamics are discussed: strengths and weaknesses as well as opportunities and threats.