bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphodiesterase-4 inhibition reduces ECLS-induced vascular permeability and improves microcirculation in a rodent model of extracorporeal resuscitation
Authors: Wollborn Jakob , Siemering Svenja , Steiger Christoph , Buerkle Hartmut , Goebel Ulrich , Schick Martin A. 
Published: January 2019

Extracorporeal circulation can be accompanied by increased vascular permeability leading to pathological fluid balance and organ dysfunction. The second messenger cAMP is involved in capillary permeability and maintains endothelial integrity. The aim of the present study was to evaluate the effect of phosphodiesterase-4 (PDE4) inhibition with rolipram on extracorporeal circulation-induced capillary leakage, microcirculatory dysfunction, and organ injury in rodents. Rats were randomly allocated to the following groups: sham ( n = 5), venoarterial extracorporeal circulation [extracorporeal life support (ECLS), n = 7], ECLS + rolipram ( n = 7), extracorporeal resuscitation (ECPR; n = 7), and ECPR + rolipram ( n = 7). In the groups that underwent ECPR, ECLS-based cardiopulmonary resuscitation (ECPR) was performed after the induction of hypoxic cardiac arrest. Upon return of spontaneous circulation, rolipram was administered intravenously. The mesenteric microcirculation was studied using intravital microscopy, and organ specimens were harvested upon completion of the study. ECLS and ECPR induced a proinflammatory response (cytokines IL-1β, IL-6, and TNF-α). Although PDE4 expression was upregulated in vascular tissue, PDE4 inhibition abrogated impaired microcirculation and capillary leak (albumin extravasation of the sham group: 1 ± 0.03-fold, ECLS group: 1.2 ± 0.05-fold, ECLS + rolipram group: 0.99 ± 0.04-fold, ECPR group: 1.6 ± 0.04-fold, and ECPR + rolipram group: 1.06 ± 0.02-fold from the sham group, P < 0.05). PDE4 inhibition led to stabilization of vascular cAMP levels but did not affect cytokine levels. Capillary leak was reduced, as demonstrated by the decrease of the systemic biomarkers soluble vascular-endothelial cadherin and activated complement 3. Histological analysis revealed reduced injury to the lungs and kidneys after PDE4 inhibition, with a significant decrease in systemic renal damage markers. Our findings demonstrate that extracorporeal circulation causes an inflammatory reaction associated with decreased vascular cAMP levels, increased vascular permeability, and impaired microcirculation. PDE4 inhibition proved to be capable of reducing these side effects in ECLS and ECPR, leading to reduced microcirculatory, renal, and pulmonary injury. NEW & NOTEWORTHY Various complications are common after extracorporeal circulation. Among these, endothelial injury may cause impaired microcirculation and capillary leak. Here, we report that phosphodiesterase-4 inhibition targeting endothelial cAMP is capable of reducing microvascular complications in a rodent model of extracorporeal resuscitation. Microcirculation and vascular permeability are influenced without targeting extracorporeal circulation-induced inflammation. Thus, pulmonary and renal organ protection may be conferred.
Keratinocyte Carcinomas: Current Concepts and Future Research Priorities
Authors: Nagarajan Priyadharsini , Asgari Maryam M. , Green Adele C. , Guhan Samantha M. , Arron Sarah T. , Proby Charlotte M. , Rollison Dana E. , Harwood Catherine A. , Toland Amanda Ewart 
Published: January 2019

AbstractCutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) are keratinocyte carcinomas, the most frequently diagnosed cancers in fair-skinned populations. Ultraviolet radiation (UVR) is the main driving carcinogen for these tumors, but immunosuppression, pigmentary factors, and aging are also risk factors. Scientific discoveries have improved the understanding of the role of human papillomaviruses (HPV) in cSCC as well as the skin microbiome and a compromised immune system in the development of both cSCC and BCC. Genomic analyses have uncovered genetic risk variants, high-risk susceptibility genes, and somatic events that underlie common pathways important in keratinocyte carcinoma tumorigenesis and tumor characteristics that have enabled development of prediction models for early identification of high-risk individuals. Advances in chemoprevention in high-risk individuals and progress in targeted and immune-based treatment approaches have the potential to decrease the morbidity and mortality associated with these tumors. As the incidence and prevalence of keratinocyte carcinoma continue to increase, strategies for prevention, including effective sun-protective behavior, educational interventions, and reduction of tanning bed access and usage, are essential. Gaps in our knowledge requiring additional research to reduce the high morbidity and costs associated with keratinocyte carcinoma include better understanding of factors leading to more aggressive tumors, the roles of microbiome and HPV infection, prediction of response to therapies including immune checkpoint blockade, and how to tailor both prevention and treatment to individual risk factors and needs.
TGFβ Blockade Enhances Radiotherapy Abscopal Efficacy Effects in Combination with Anti-PD1 and Anti-CD137 Immunostimulatory Monoclonal Antibodies
Authors: Rodríguez-Ruiz María E. , Rodríguez Inmaculada , Mayorga Lina , Labiano Tania , Barbes Benigno , Etxeberria Iñaki , Ponz-Sarvise Mariano , Azpilikueta Arantza , Bolaños Elixabet , Sanmamed Miguel F. , Berraondo Pedro , Calvo Felipe A. , Barcelos-Hoff Mary Helen , Perez-Gracia Jose L. , Melero Ignacio 
Published: January 2019

AbstractRadiotherapy can be synergistically combined with immunotherapy in mouse models, extending its efficacious effects outside of the irradiated field (abscopal effects). We previously reported that a regimen encompassing local radiotherapy in combination with anti-CD137 plus anti–PD-1 mAbs achieves potent abscopal effects against syngeneic transplanted murine tumors up to a certain tumor size. Knowing that TGFβ expression or activation increases in irradiated tissues, we tested whether TGFβ blockade may further enhance abscopal effects in conjunction with the anti–PD-1 plus anti-CD137 mAb combination. Indeed, TGFβ blockade with 1D11, a TGFβ-neutralizing mAb, markedly enhanced abscopal effects and overall treatment efficacy against subcutaneous tumors of either 4T1 breast cancer cells or large MC38 colorectal tumors. Increases in CD8 T cells infiltrating the nonirradiated lesion were documented upon combined treatment, which intensely expressed Granzyme-B as an indicator of cytotoxic effector capability. Interestingly, tumor tissue but not healthy tissue irradiation results in the presence of higher concentrations of TGFβ in the nonirradiated contralateral tumor that showed smad2/3 phosphorylation increases in infiltrating CD8 T cells. In conclusion, radiotherapy-induced TGFβ hampers abscopal efficacy even upon combination with a potent immunotherapy regimen. Therefore, TGFβ blockade in combination with radioimmunotherapy results in greater efficacy.
Insight into the Etiology of Undifferentiated Soft Tissue Sarcomas from a Novel Mouse Model
Authors: Fleming Jonathan T. , Brignola Emily , Chen Lei , Guo Yan , Zhao Shilin , Wang Quan , Li Bingshan , Correa Hernán , Ermilov Alexandre N. , Dlugosz Andrzej A. , Chiang Chin 
Published: January 2019

Abstract

Aberrant activation of the Hedgehog signaling pathway has been linked to the formation of numerous cancer types, including the myogenic soft tissue sarcoma, embryonal rhabdomyosarcoma (eRMS). Here, we report PCG2, a novel mouse model in which human GLI2A, a constitutive activator of Hedgehog signaling, induced undifferentiated sarcomas that were phenotypically divergent from eRMS. Rather, sarcomas arising in PCG2 mice featured some characteristics that were reminiscent of Ewing sarcoma. Even though it is widely understood that Ewing sarcoma formation is driven by EWS-ETS gene fusions, a genetically defined mouse model is not well-established. While EWS-ETS gene fusions were not present in PCG2 sarcomas, precluding their designation as Ewing sarcoma, we did find that GLI2A induced expression of known EWS-ETS gene targets essential to Ewing pathogenesis, most notably, Nkx2.2. Moreover, we found that naïve mesenchymal progenitors originate tumors in PCG2 mice. Altogether, our work provides a novel genetic mouse model, which directly connects oncogenic Hedgehog activity to the etiology of undifferentiated soft tissue sarcomas for the first time.

Implications:
The finding that activation of Gli2 transcription factor is sufficient to induce Ewing-like sarcomas provides a direct transformative role of the Hedgehog signaling pathway in undifferentiated soft tissue sarcoma.
Age Invariant Face Recognition using Convolutional Neural Network
Authors: Nimbarte Mrudula , Bhoyar Kishor 
Published: January 2019

<span>In the recent years, face recognition across aging has become very popular and challenging task in the area of face recognition. Many researchers have contributed in this area, but still there is a significant gap to fill in. Selection of feature extraction and classification algorithms plays an important role in this area. Deep Learning with Convolutional Neural Networks provides us a combination of feature extraction and classification in a single structure. In this paper, we have presented a novel idea of 7-Layer CNN architecture for solving the problem of aging for recognizing facial images across aging. We have done extensive experimentations to test the performance of the proposed system using two standard datasets FGNET and MORPH</span><span>(Album II). Rank-1 recognition accuracy of our proposed system is 76.6% on FGNET and 92.5% on MORPH</span><span>(Album II). Experimental results show the significant improvement over available state-of- the-arts with the proposed CNN architecture and the classifier.</span>
Throughput Maximization of Cognitive Radio Multi Relay Network with Interference Management
Authors: Varade Pradip , Wabale Akanksha , Yerram Ravinder , Jaiswal Rupesh 
Published: January 2019

<span>In this paper, an Orthogonal Frequency Division Multiplexing (OFDM) based cognitive multi relay network is investigated to maximize the transmission rate of the cognitive radio (CR) with enhanced fairness among CR users with interference to the primary users (PUs) being managed below a certain threshold level. In order to improve the transmission rate of the CR, optimization of the subcarrier pairing and power allocation is to be carried out simultaneously. Firstly joint optimization problem is formulated and Composite Genetic and Ordered Subcarrier Pairing (CGOSP) algorithm is proposed to solve the problem. The motivation behind merging genetic and OSP algorithm is to reduce the complexity of Genetic Algorithm (GA). Further, to have a fair allocation of resources among CR users, the Round Robin allocation method is adopted so as to allocate subcarrier pairs to relays efficiently. The degree of fairness of the system is calculated using Jain’s Fairness Index (JFI). Simulation results demonstrate the significant improvement in transmission rate of the CR, low computational complexity and enhanced fairness.</span>
A Survey: Data Leakage Detection Techniques
Authors: Wagh K. S. 
Published: January 2019

Data is an important property of various organizations and it is intellectual property of organization. Every organization includes sensitive data as customer information, financial data, data of patient, personal credit card data and other information based on the kinds of management, institute or industry. For the areas like this, leakage of information is the crucial problem that the organization has to face, that poses high cost if information leakage is done. All the more definitely, information leakage is characterize as the intentional exposure of individual or any sort of information to unapproved outsiders. When the important information is goes to unapproved hands or moves towards unauthorized destination. This will prompts the direct and indirect loss of particular industry in terms of cost and time. The information leakage is outcomes in vulnerability or its modification. So information can be protected by the outsider leakages. To solve this issue there must be an efficient and effective system to avoid and protect authorized information. From not so long many methods have been implemented to solve same type of problems that are analyzed here in this survey. This paper analyzes little latest techniques and proposed novel Sampling algorithm based data leakage detection techniques.
Background Estimation Using Principal Component Analysis Based on Limited Memory Block Krylov Subspace Optimization
Authors: Sari Ilmiyati , Juarna Asep , Harmanto Suryadi , Kerami Djati 
Published: January 2019

<p>Given a video of 𝑀 frames of size ℎ × 𝑤. Background components of a video are the elements matrix which relative constant over 𝑀 frames. In PCA (principal component analysis) method these elements are referred as “principal components”. In video processing, background subtraction means excision of background component from the video. PCA method is used to get the background component. This method transforms 3 dimensions video (ℎ × 𝑤 × 𝑀) into 2 dimensions one (𝑁 × 𝑀), where 𝑁 is a linear array of size ℎ × 𝑤. The principal components are the dominant eigenvectors which are the basis of an eigenspace. The limited memory block Krylov subspace optimization then is proposed to improve performance the computation. Background estimation is obtained as the projection each input image (the first frame at each sequence image) onto space expanded principal component. The procedure was run for the standard dataset namely SBI (Scene Background Initialization) dataset consisting of 8 videos with interval resolution [146 150, 352 240], total frame [258,500]. The performances are shown with 8 metrics, especially (in average for 8 videos) percentage of error pixels (0.24%), the percentage of clustered error pixels (0.21%), multiscale structural similarity index (0.88 form maximum 1), and running time (61.68 seconds). </p>
Proportional Resonant Controlled Dual Active Bridge DC to AC Converter System with Enhanced Response
Authors: Sowmya R. , Reddy S. Rama 
Published: January 2019

<p>This paper deals with comparison of responses of PI and Proportional Resonant controlled DC to AC Converter systems. The objective of this work is to regulate the output of Dual Active Bridge DC to DC converter (DABDAC). The input DC is converted into high frequency AC using Half bridge inverter. It is stepped up by using step up transformer and then it is rectified. The DC is converted into Low frequency AC using a Half bridge inverter. The open loop DABDAC system, closed loop PI based DABDAC system an Proportional Resonant Controller (PRC)based DABDAC system are designed, modeled and simulated using MATLAB Simulink. The results of PR controlled system are compared with those of PI controlled system. The results indicate that the proposed PRC-DABDAC has better time domain response than PI controlled DABDAC system. The proposed DABDAC system has advantages like high gain and steady state error in output voltage. </p>
A Novel Approach in Scheduling Of the Real- Time Tasks In Heterogeneous Multicore Processor with Fuzzy Logic Technique For Micro-grid Power Management
Authors: Dhanesh Lavanya , Murugesan P. 
Published: January 2019

Scheduling of tasks based on real time requirement is a major issue in the heterogeneous multicore systemsfor micro-grid power management . Heterogeneous multicore processor schedules the serial tasks in the high performance core and parallel tasks are executed on the low performance cores. The aim of this paper is to implement a scheduling algorithm based on fuzzy logic for heterogeneous multicore processor for effective micro-grid application. Real – time tasks generally have different execution time and dead line. The main idea is to use two fuzzy logic based scheduling algorithm, first is to assign priority based on execution time and deadline of the task. Second , the task which has assigned higher priority get allotted for execution in high performance core and remaining tasks which are assigned low priority get allotted in low performance cores. The main objective of this scheduling algorithm is to increase the throughput and to improve CPU utilization there by reducing the overall power consumption of the micro-grid power management systems. Test cases with different task execution time and deadline were generated to evaluate the algorithms using MATLAB software.
Palatal Sphincter Pharyngoplasty With Cephalic Mucosa Preservation in Selected Cases of Velopharyngeal Insufficiency
Authors: Askar Sherif M. , Quriba Amal S. 
Published: January 2019

Objectives: Sphincter pharyngoplasty is a commonly performed procedure for the treatment of velopharyngeal insufficiency and is often indicated in patients with circular or coronal closure patterns of the velopharyngeal sphincter. The authors present a modified technique of sphincter pharyngoplasty (partially mucosalized palatal sphincter pharyngoplasty [PMPSP]) in which bilateral superiorly based myomucosal palatopharyngeal flaps were elevated (in a newly designed fashion) and inserted in the palate through preformed palatal tunnels. Methods: This case series included 14 patients (5 male, 9 female) with persistent hypernasality who were subjected to treatment by PMPSP between May 2015 and August 2018. The palatopharyngeal flap was designed to be full thickness at its caudal segment, while its cephalic segment was denuded of its mucosa. The cephalic mucosa (of the flap) was elevated off the bed muscles as a medially based mucosa flap to be used at the end of the procedure to drape the upper part of the bed. Results: Pain assessed using a visual analog scale had decreased significantly at day 10 after surgery, and normal oral feeding was regained within 7 to 10 days. No major complications were recorded. Postoperative nasoendoscopic and phoniatric assessments were reported. Statistically significant improvements were reported when comparing pre- versus postoperative auditory perceptual assessment following PMPSP. Conclusions: The newly reported PMPSP might be a useful technique for correction of velopharyngeal insufficiency in patients with weak palatal motion (coronal or circular pattern of velopharyngeal sphincter closure). PMPSP had good reported surgical and phoniatric outcomes.
Power Analysis of Collapsed Ordered Categories with Application to Cancer Data
Authors: Maity Arnab Kumar , Dey Jyotirmoy 
Published: January 2019

Ordinal data are often found in clinical studies. Sometimes the analysis of this data is done using binary logistic regression after collapsing the categories of ordinal responses. However, these analyses may not be appropriate in practice because either the assumptions are violated or because the information is lost. Cumulative logistic regression is shown to be a better alternative approach. The efficiency of cumulative logistic regression is demonstrated using simulation studies. A novel sequential testing approach is suggested in the context of cancer data. In addition, in the absence of the proper knowledge of the data, an automatic data-driven approach is also proposed. The efficacy of these proposals are illustrated via simulation studies. AMS 2000 subject classification code: 92D99
On Log-q-Gaussian Distribution
Authors: Koike Ken-ichi , Shimegi Yuya 
Published: January 2019

We propose the log- q-Gaussian distribution which is obtained as the distribution of a random variable whose logarithm is q-Gaussian. Various types of properties of the new distribution are given such as the moments, the cumulative distribution function, the extreme value distribution, the likelihood estimation, and so on. Some examples for real data are also given. AMS Classification: 60Exx 62Exx.
Experiences of Adolescents and Emerging Adults Living With Type 1 Diabetes
Authors: Datye Karishma , Bonnet Kemberlee , Schlundt David , Jaser Sarah 
Published: January 2019

Purpose The purpose of this study was to identify barriers to adherence in type 1 diabetes through adolescent focus groups and to use this information to determine how diabetes educators can have a positive impact on their patients’ diabetes management. Methods Two focus groups were conducted with adolescents and young adults (n = 11) ages 17 to 21 with type 1 diabetes. A focus group script, which consisted of 4 open-ended questions about diabetes care and challenges associated with management of diabetes, was used to elicit discussion. The focus group transcripts were coded and analyzed using the inductive-deductive approach. Results Participants described unique barriers to and facilitators of self-care behaviors in their management of type 1 diabetes. A conceptual framework was developed to describe adherence to self-management in adolescents with type 1 diabetes. Biological, psychological, and environmental situational influences emerged that influence self-care behaviors. In addition, facilitators of self-care behaviors, including the health system and diabetes education, were identified, and together the interaction between situational influences, facilitators, and self-care behaviors influenced adherence to diabetes treatment. Conclusions The conceptual framework based on these focus groups may help diabetes educators assess and address barriers to self-care behaviors in adolescents and young adults with type 1 diabetes.
Delayed diagnosis of long QT syndrome in a patient with seizures
Authors: Shin Seung Yong , Hong Jun Young , Lee Dong Hoon 
Published: January 2019

Introduction: Long QT syndrome accompanied by a seizure episode is often misdiagnosed as primary epilepsy. Although patients with Long QT syndrome who are misdiagnosed and improperly managed are likely to result in fatality, their first clinical manifestations are seizure episodes in many cases. Case presentation: A 17-year-old boy visited the emergency department with poorly controlled seizure during epilepsy treatment was found to have been misdiagnosed with epilepsy when he was 7 years old. His electrocardiography showed a prolonged QT interval. After careful re-evaluation, he was finally diagnosed with Long QT syndrome and recovered without any seizure episodes in the absence of anti-epileptic agents. Discussion and conclusion: Careful initial assessment including repetitive electrocardiography, when abnormal, is required for those who visit the emergency department with a seizure or who show no definite abnormalities in diagnostic work up process.
Insulin-Based Infusion System: Preliminary Study
Authors: Hashemi Nasseh , Valk Tim , Houlind Kim , Ejskjaer Niels 
Published: January 2019

Background: Optimal glucose control has been shown to be useful in critical care as well as in other settings. Glucose concentrations in patients admitted to critical care are characterized by marked variability and hypoglycemia due to inadequate sensing and treatment technologies. Methods: The insulin balanced infusion system (IBIS) is a closed-loop system that uses a system controller, two syringe pumps, and capillary glucose sensor intravenously infusing regular insulin and/or dextrose. The IBIS performance was evaluated in terms of glucose stability in response to various conditions in subjects with type 1 and insulin requiring type 2 diabetes mellitus (n = 15) with frequent intermittent capillary measurements, entered into the system and an adaptive algorithm adjusting the treatment modalities without other nursing intervention. Results: Target glucose concentrations (80-125 mg/dl) were achieved from hyperglycemic levels in 2.49 hours in the first study with mean and standard deviation of 105.2 mg/dl and 11.5 mg/dl, respectively. Conclusion: Preliminary studies using a prototype closed-loop glucose control system for critical care produced noticeable results. Improvements were initiated within the system and further studies performed.