bluuebunny/crossref_metadata_2025_split huggingface dataset:
SSA‐ZP on Scalp Seborrheic Dermatitis: Regulating Sebum Levels and Scalp Barrier
Authors: Wang Qi , Liu Yufang , Ye Congxiu , Shen Jing , Lin Jiahui , Du Yunfan , Li Lintong , Huang Xiaowen , Zheng Yue 
Published: October 2024

ABSTRACTBackgroundThe occurrence of scalp seborrheic dermatitis (SD) is closely related to the production of sebum and scalp barrier function. Supramolecular salicylic acid has the keratolytic and anti‐inflammatory properties, and zinc pyrithione is an antifungal drug delivered as a microparticle to skin epithelia.ObjectiveThis study aimed to assess the efficacy and safety of 2% supramolecular salicylic acid (SSA) combined with 0.8% zinc pyrithione conditioner (SSA‐ZP) in treating scalp SD focusing on key outcome measures including sebum levels and scalp barrier function.MethodsFive patients with mild to moderate scalp SD were included in the 2‐week self‐controlled prospective study, receiving daily SSA‐ZP treatment. Evaluation on days 0, 7, and 14 included dermoscopy, the adherent scalp flaking scale (ASFS), sebum level, transepidermal water loss (TEWL), pH, and stratum corneum hydration. We also performed the fungal count across specific scalp regions, such as the left and right sides of the forehead, the top of the head, and the occiput.ResultsFive patients with mild to moderate scalp SD participated in this study. After 2 weeks of SSA‐ZP treatment, significant reductions in ASFS scores, sebum levels, and fungal count were observed, alongside improvements in TEWL and pH values across multiple scalp regions. Moreover, there was no difference in the hydration of stratum corneum.ConclusionSSA‐ZP demonstrated efficacy in treating scalp SD without adverse effects, suggesting its potential as a first‐line treatment option. Further research with larger sample sizes and longer follow‐up periods is warranted to validate these findings.
The Effect of Perceptions of Evidence‐Based Practice on Endotracheal Cuff Pressure Management in Critical Care Nurses: A Correlational Cross‐Sectional Multicentre Study
Authors: Budak Ertürk Elif , Çevik Banu , Kiliç Gülşen , Çelikateş Nevin , Fulser Berrak 
Published: October 2024

ABSTRACTAimsThis correlational cross‐sectional multicentre study aims to achieve two objectives. Firstly, to assess nurses' knowledge and practice of endotracheal cuff pressure management. Secondly, to examine the relationship between endotracheal cuff pressure management knowledge and evidence‐based practice leadership and work environment.DesignA correlational cross‐sectional multicentre study design.MethodsThis study was conducted among 144 intensive care nurses in Turkey. Data collection included descriptive characteristics and cuff pressure management of nurses, the Evidence‐Based Practice Leadership Scale and Evidence‐Based Practice Work Environment Scale. Descriptive statistics, chi‐square test, Pearson correlation and receiver operating characteristics analysis were conducted. A STROBE checklist was the reporting guide for this study.ResultsThe success status of nurses in terms of knowledge related to cuff pressure was found significantly different according to the type of intensive care unit working in and the status of receiving training on evidence‐based practice. A positive, strong relationship was found between nurses' mean scores on the Evidence‐Based Practice Leadership Scale and the Work Environment Scale. There was a very weak positive correlation between the mean scores of the Evidence‐Based Practice Leadership Scale and the cuff pressure management.ConclusionAdherence by nurses to current evidence‐based practice for cuff pressure monitoring is essential for safe patient care and improved quality of care. It is recommended to provide both a supportive working environment and training programmes for intensive care nurses to perform cuff pressure management in line with evidence‐based practice.Relevance to Clinical PracticeProviding educational programs, an appropriate clinical environment, support from health managers and access to appropriate tools are important considerations in increasing the knowledge and skills of intensive care nurses to effectively monitor and manage cuff pressure.Reporting MethodOur study complies with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Checklist: cross‐sectional studies.Patient or Public ContributionNo patient or public contribution.
Equilibrium Data Mining and Data Abundance
Authors: DUGAST JÉRÔME , FOUCAULT THIERRY 
Published: October 2024

ABSTRACTWe study theoretically how the proliferation of new data (“data abundance”) affects the allocation of capital between quantitative and nonquantitative asset managers (“data miners” and “experts”), their performance, and price informativeness. Data miners search for predictors of asset payoffs and select those with a sufficiently high precision. Data abundance raises the precision of the best predictors, but it can induce data miners to search less intensively for high‐precision signals. In this case, their performance becomes more dispersed and they receive less capital. Nevertheless, data abundance always raises price informativeness and can therefore reduce asset managers' average performance.
Applying the FRAME for Systematic Adaptation of a State Health Curriculum to Enhance Physical Activity and Family Engagement
Authors: Schwartz Anna , Eisman Andria B. , Gagliardi Lisa Jo , Hasson Rebecca E. 
Published: October 2024

ABSTRACTBACKGROUNDA systematic adaptation of an evidence‐based state health curriculum (Michigan Model for Health™, MMH) was created to enhance physical activity and family engagement materials but retain the core functional elements of the curriculum.METHODSThe Framework for Reporting Adaptations and Modifications‐Enhanced (FRAME) was used to document the adaptation, which used materials from an evidence‐informed physical activity program (Interrupting Prolonged sitting with ACTivity, InPACT). Acceptability, appropriateness, feasibility, and perceived value of the adaptation were assessed by key stakeholders, regional school health coordinators (HCs).RESULTSA planned, fidelity‐consistent adaptation was created in which InPACT resources were integrated into the MMH curriculum, with recommended integrations packaged in a supplemental guide. Training was modified as appropriate. The guide had high acceptability, appropriateness, and feasibility among HCs (n = 17), and 71% of HCs (n = 24) indicated that it had really strong value.CONCLUSIONSNext steps involve implementing the adapted curriculum and evaluating its effects on family engagement, youth physical activity levels, and overall curriculum effectiveness.
Lineage‐specific duplication of a CYCLOIDEA2 gene and the diversification of capitula in the tribe Anthemideae (Asteraceae)
Authors: Rong Yu‐Lin , Niu Chen‐Yu , Zhang Chu‐Jie , Guo Yan‐Ping , Rao Guang‐Yuan 
Published: October 2024

AbstractGene duplications have contributed to the innovation of morphological traits during plant evolution. An outstanding example is the role of CYCLOIDEA2 (CYC2) gene duplications in the formation of the complex structure of Asteraceae capitula. Previous studies have shown that Chrysanthemum lavandulifolium (Fischer ex Trautv.) Makino and a few other species of the Asteraceae harbor two copies of CYC2e. Here, we identified a lineage‐specific CYC2e duplication event at the root of the phylogeny of the tribe Anthemideae by analyzing the evolutionary history of CYC2 genes across the Asteraceae. Although the gene expression patterns of CYC2e1 and CYC2e2 were similar in most of floral organs, CYC2e1 promoted ligule elongation by promoting cell expansion, whereas CYC2e2 showed a weak inhibiting effect on the ray‐floret development, and overexpression of CYC2e2 resulted in the maldevelopment of stamens in disc florets. These results indicated differentiated functions of CYC2e1 and CYC2e2 in the capitulum development of the Anthemideae. Given the previous data that identified CYC2g and CYC2d as main regulators in ligule morphogenesis, we comparatively analyzed 10 Asteraceae genomic data, and identified tandem arrays of CYC2g, CYC2d, and CYC2e. We further investigated the regulatory relationships between CYC2g/CYC2d and CYC2e genes, and found that CYC2g can activate the expression of CYC2e1. The findings of this study elucidate the synergistic roles of CYC2 genes in regulating the formation of the Asteraceae capitula and enhance understanding of the mechanism of duplicated gene retention during plant evolution.
Harnessing microbes as sun cream against high light stress
Authors: Villano Filippo , Balestrini Raffaella , Nerva Luca , Chitarra Walter 
Published: October 2024

SummaryPlants rely on solar energy for growth through photosynthesis, yet excessive light intensity can induce physiological damage. Despite the considerable harm, inadequate attention has been directed toward understanding how plant‐associated microorganisms mitigate this stress, and the impact of high light intensity on plant microbial communities remains underexplored. Through this Viewpoint, we aim to highlight the potential of microbial communities to enhance plant resilience and understand how light stress can shape plant microbiome. A full understanding of these dynamics is essential to design strategies that take advantage of microbial assistance to plants under light stress and to effectively manage the impact of changing light conditions on plant–microbe interactions.
Water, not carbon, drives drought‐constraints on stem terpene defense against simulated bark beetle attack in Pinus edulis
Authors: Malone Shealyn C. , Thompson R. Alex , Chow Pak S. , de Oliveira Celso R. , Landhäusser Simon M. , Six Diana L. , McCulloh Katherine A. , Adams Henry D. , Trowbridge Amy M. 
Published: October 2024

Summary
Drought predisposes forest trees to bark beetle‐induced mortality, but the physiological mechanisms remain unclear. While drought‐induced water and carbon limitations have been implicated in defensive failure and tree susceptibility, evidence demonstrating how these factors interact is scarce.
We withheld water from mature, potted Pinus edulis and subsequently applied a double‐stem girdle to inhibit carbohydrate transport from the crown and roots. Within this isolated segment we then elicited a defense response by inoculating trees with a bark beetle‐fungal symbiont (Ophiostoma sp.). We quantified local mono‐ and sesquiterpenes (MST), nonstructural carbohydrates (NSC), and pressure potential of the inner bark.
Both drought‐stressed and watered trees had similar NSC concentrations just before inoculation and depleted NSC similarly following inoculation, yet MST induction (i.e. increased concentration and altered composition) was constrained only in drought‐stressed trees. Thus, NSC consumption was largely unrelated to de novo MST synthesis. Instead, stoichiometric calculations show that induction originated largely from stored resin. Watered trees experiencing higher pressure potentials consistently induced higher MST concentrations.
We demonstrate the importance of preformed resin toward an induced MST response in a semi‐arid conifer where drought‐constraints on defense occurred through biophysical limitations (i.e. reduced turgor hindering resin transport) rather than through substrate limitation.
Ageing‐Related Macrophage Polarisation in the Trigeminal Ganglion Enhances Incisional Intraoral Pain
Authors: Urata Kentaro , Oto Tatsuki , Hayashi Yoshinori , Hitomi Suzuro , Ikeda Takayuki , Iwata Koichi , Iinuma Toshimitsu , Shinoda Masamichi 
Published: October 2024

ABSTRACTObjectiveAlthough macrophage polarisation in the trigeminal ganglion (TG) is crucial in orofacial pain hypersensitivity, the effect of ageing‐related changes and their involvement in intra‐oral nociception remains unclear. We assessed the effect of ageing‐related macrophage polarisation in TG on intra‐oral mechanical pain hypersensitivity following palatal mucosal incision using senescence‐accelerated mice (SAM)‐prone8 (SAMP8) and SAM‐resistant 1 (SAMR1).Materials and MethodsMechanical head‐withdrawal reflex threshold (MHWRT) of the palatal mucosa was measured for 21 days after palatal mucosal incision. On days 3 and 14, the abundance of Iba‐1‐immunoreactive (IR) cells, CD11c‐IR cells (pro‐inflammatory macrophages (M1)), C‐C motif chemokine ligand 2 (CCL2)‐IR M1‐macrophages, CD206‐IR cells (anti‐inflammatory macrophages (M2)) and transforming growth factor‐β (TGF‐β)‐IR M2‐macrophages in the TG was analysed. The effect of continuous intra‐TG administration of CCL2‐neutralising antibody or recombinant‐CCL2 on MHWRT was examined.ResultsIncision‐induced decrease in MHWRT was enhanced in SAMP8 compared with that in SAMR1. On days 3 and 14, the number of CCL2‐IR M1‐macrophages in TG was increased in SAMP8 compared with that in SAMR1. CCL2‐neutralising antibody suppressed, whereas recombinant‐CCL2 increased pain hypersensitivity in SAMP8.ConclusionsMechanical pain hypersensitivity after oral mucosal injury is potentiated and sustained by age‐related enhancement of CCL2 signalling via M1‐macrophage hyperactivation in TG.
CaWRKY20 Negatively Regulates Plant Resistance to Colletotrichum scovillei in Pepper
Authors: Li Yang , Ma Xiao , Xiao Luo‐Dan , Yu Ya‐Nan , Gong Zhen‐Hui 
Published: October 2024

ABSTRACTChili anthracnose, a fungal disease caused by Colletotrichum scovillei, is among the most devastating diseases affecting pepper (Capsicum annuum L.). Although WRKY transcription factors play important roles in plant immunity, it is unknown how WRKY gene family members contribute to pepper plant resistance to C. scovillei. Here, CaWRKY20 was found to negatively regulate pepper resistance to C. scovillei, which was demonstrated by virus‐induced gene silencing and transient overexpression in pepper. Moreover, overexpression of CaWRKY20 enhanced susceptibility to C. scovillei in tomato. Additionally, our findings demonstrated that CaWRKY20 can indirectly regulate the expression of salicylic acid (SA)‐related defense genes (CaPR1, CaPR10 and CaSAR8.2) as well as reactive oxygen species (ROS)‐scavenging enzyme genes (CaCAT, CaPOD and CaSOD) in response to C. scovillei. In addition, CaWRKY20 was found to interact with CaMIEL1 in the nucleus to regulate the defense response to C. scovillei in pepper. Furthermore, CaWRKY20 directly bound to the W‐box in the promoter of SYSTEMIC ACQUIRED RESISTANCE DEFICIENT 1 (CaSARD1) and suppressed its expression, resulting in reduced resistance to C. scovillei. These results will clarify the mechanism by which WRKY transcription factors are involved in pepper disease resistance and can thus facilitate molecular breeding for anthracnose‐resistant varieties.
Bay 11‐7082, an NF‐κB Inhibitor, Prevents Post‐Inflammatory Hyperpigmentation Through Inhibition of Inflammation and Melanogenesis
Authors: Moon Juwon , Moon Ik Jun , Hyun Hoyong , Yoo Jae Min , Bang Seung Hyun , Song Youngsup , Chang Sung Eun 
Published: October 2024

ABSTRACTPost‐inflammatory hyperpigmentation (PIH) is a very common disorder of cutaneous hyperpigmentation, which poses a persistent management challenge in the fields of dermatology and esthetics. This study was designed to explore the anti‐melanogenic and anti‐inflammatory effects of Bay 11‐7082, an NF‐κB inhibitor, using small‐molecule screening, to determine its potential application for PIH prevention. The molecular mechanisms were investigated in vitro and ex vivo in epidermis‐humanized mice using melanin content, RT‐PCR, and immunoblotting. Bay 11‐7082 suppressed proinflammatory cytokines and ameliorated 2,4‐dinitrofluorobenzene (DNFB)‐induced contact dermatitis on day 15. The suppression of melanin synthesis by Bay 11‐7082 was attributed to the reduction of MITF, which was induced by extracellular signal‐regulated kinase activation. Bay 11‐7082 reduced epidermal melanin accumulation in UVB‐stimulated ex vivo human epidermis as well as in the ear and tail skin of K14‐stem cell factor (SCF) transgenic mice. Topical administration of Bay 11‐7082 improved PIH on day 35 in the post‐DNFB dorsal skin of K14‐SCF transgenic mice. In conclusion, Bay 11‐7082 can be considered a promising candidate for the development of a preventive topical agent for PIH.
The Impact of Reduced Immunosuppression on Alloimmunity: A Retrospective Study of Pediatric Kidney Transplant Recipients
Authors: Gramkow Ann‐Maria , Baatrup Johanne H. , Gramkow Emilie T. , Koefoed‐Nielsen Pernille , Wittenhagen Per , Thiesson Helle C. 
Published: October 2024

ABSTRACTBackgroundKidney transplantation is the best treatment for end‐stage kidney disease but requires immunosuppressive medications, which have significant side effects. Many pediatric recipients experience these side effects, leading to dosage reductions, which potentially increase the risk of alloimmunity. We aimed to describe the alteration in immunosuppressive medication, explore the reasons for the reductions, and assess the potential impact on alloimmunity.MethodData from 49 pediatric kidney transplant recipients receiving an allograft from 2009 to 2020 were retrospectively studied. The recipients were screened for HLA antibodies after the transplantation.ResultsThe median age of recipients was 11 years (IQR 8), with a median follow‐up of 5 years (IQR 5). Eighty percent of the transplantations were corticosteroid‐free. During follow‐up, 11% developed de novo donor‐specific antibodies (dnDSA), and 60% had detectable HLA antibodies. The 1‐year rejection rate was 4%. Immunosuppressive medication was altered substantially in most recipients, resulting in 72% being on mono‐ or dual therapy with a reduced mycophenolate mofetil (MMF) dosage by the end of the first posttransplant year. The median MMF dose was nearly half of the intended. Tacrolimus levels were maintained close to the target of 5 ng/mL. No association was found between reduced immunosuppression and dnDSA or rejections. Reductions were primarily due to MMF‐related side effects: leukopenia in 77%, gastrointestinal issues in 34%, and infections with Epstein–Barr virus, cytomegalovirus, and BK polyomavirus in 49%.ConclusionsReduced MMF with a sufficient trough tacrolimus level in a population of mainly corticosteroid‐free pediatric kidney transplant recipients did not lead to unacceptable alloimmunity.
Differential expression of hemolymph proteins in wild bumblebees provides insights into species‐specific impacts of heat stress
Authors: Przybyla Kimberly , Martinet Baptiste , Michez Denis , Bocquet Michel , Askri Dalel , Bulet Philippe 
Published: October 2024

AbstractWildlife faces an increasing threat from extreme climatic events, such as heatwaves, which can have a severe impact on various species, including crucial pollinators like bumblebees. Bumblebees are cold‐adapted and heterothermic, possessing the ability to regulate their internal temperature. The impact of heat stress seems species specific in bumblebees. While most species are impacted, some bumblebee species manage to survive, potentially by employing physiological mechanisms, including the modulation of their protein profile (e.g. Heat Shock Proteins). However, there is limited understanding of how their protein profiles are associated with heat exposure. In this study, we examined the global variation in the protein profile of males from two bumblebee species sampled in the wild: the heat‐tolerant Bombus terrestris and the heat‐sensitive Bombus magnus. After subjecting them to heat stupor at 40°C in controlled condition, it was observed that nearly all B. terrestris survived the stress, while over 50% of B. magnus individuals succumbed to the heat exposure. Through off‐gel bottom‐up proteomics and LC–MS/MS analysis of the hemolymph proteome, we identified 164 proteins in both species with a large part of differentially expressed proteins after heat exposure. Additionally, quantitative analysis of fat bodies revealed that the relative mass was stable in B. terrestris, while it was significantly lower in B. magnus exposed to heat stress. Our data suggest that compared with B. magnus, B. terrestris displays a higher adaptability of its hemolymph proteome in response to heat stress. This adaptability could be a key factor contributing to the high physiological resistance of B. terrestris and its ability to adapt to new, stressful environments expected due to climate change. Understanding these mechanisms of protein regulation in bumblebees could provide valuable insights into their resilience and vulnerability facing environmental stresses.
Can overarching rules and coordination in polycentric governance help achieve pre‐identified institutional goals over time? Evidence from farmland governance in southeastern France
Authors: Kassis Grâce , Bertrand Nathalie 
Published: October 2024

AbstractThe question of the performance of polycentric governance over time is insufficiently addressed in the literature. By performance, we refer to the ability of polycentric governance actors to design rules and engage in coordination processes that allow them to achieve their goals. Through an institutional analysis, this paper seeks to answer a question that remains unresolved in the field, namely the effectiveness of the overarching set of rules and coordination relationships in their ability to drive institutional and organizational change in polycentric governance processes. To this end, we conduct an in‐depth case study of farmland governance in southeastern France. Through the attributes of polycentric governance, we examine the changes brought about by the goal of local food supply comparing it with other historical goals such as farmland preservation. We show that farmland governance is characterized by an institutional mismatch that prevents its actors from moving closer to the objective of local food supply. We argue that the evolution of farmland governance comes down to organizational change that does not lead to an evolution of rules‐in‐use. We discuss this result in light of the findings of the literature on polycentric governance and its implications for public policy.
Rogue wave patterns associated with Adler–Moser polynomials featuring multiple roots in the nonlinear Schrödinger equation
Authors: Lin Huian , Ling Liming 
Published: October 2024

AbstractIn this work, we analyze the asymptotic behaviors of high‐order rogue wave solutions with multiple large parameters and discover novel rogue wave patterns, including modified claw‐like, one triple root (OTR)‐type, modified OTR‐type, two triple roots (TTR)‐type, semimodified TTR‐type, and modified TTR‐type patterns. A correlation is established between these rogue wave patterns and the root structures of the Adler–Moser polynomials with multiple roots. At the positions in the ‐plane corresponding to simple roots of the Adler–Moser polynomials, these high‐order rogue wave patterns asymptotically approach first‐order rogue waves. At the positions in the ‐plane corresponding to multiple roots of the Adler–Moser polynomials, these rogue wave patterns asymptotically tend toward lower‐order fundamental rogue waves, dispersed first‐order rogue waves, or mixed structures of these rogue waves. These structures are related to the root structures of special Adler–Moser polynomials with new free parameters, such as the Yablonskii–Vorob'ev polynomial hierarchy, among others. Notably, the positions of the fundamental lower‐order rogue waves or mixed structures in these rogue wave patterns can be controlled freely under specific conditions.