bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of hyperbaric oxygen therapy on uncomplicated incisional and open wound healing in dogs
Authors: Latimer Christian R. , Lux Cassie N. , Roberts Sarah , Drum Marti G. , Braswell Cheryl , Sula Mee Ja M. 
Published: July 2018

AbstractObjectiveTo determine the safety of a hyperbaric oxygen therapy (HBOT) protocol and its influence on the healing of uncomplicated open and incisional wounds in dogs.Study designProspective, controlled experimental study.AnimalsAdult dogs (n = 10).MethodsTwo 2 × 2‐cm open wounds and two 3‐cm‐long full‐thickness dermal incisions were created on the dorsum of each dog. Dogs in the hyperbaric oxygen treatment group (HBO) received HBOT once daily (1.7 atmospheres absolute [ATA], 30 minutes on day 1; 2.0 ATA, 40 minutes on days 2‐7) for 7 consecutive days, and dogs in the control group (CON) received standardized wound care. Dogs were monitored during HBOT for adverse side effects. Total wound area, percentage epithelialization, and percentage contraction were compared for the open wounds. Subjective wound scores were compared for the open and incisional wounds. Biopsies of both wound types were taken and used to determine histopathology scores. Bacterial cultures were completed on open wounds.ResultsNo difference was detected between HBO and CON uncomplicated open and incisional wounds at any time for contraction, epithelialization, subjective wound scores, histopathology scores, or bacterial loads. All HBO dogs tolerated hyperbaric oxygen treatments with no adverse effects.ConclusionThe HBOT protocol tested here was safe but did not enhance the healing of uncomplicated acute wounds and incisions of dogs.Clinical significanceThese results do not provide evidence to support the use of HBOT to manage uncomplicated wounds in dogs.
The T-Box Riboswitch: tRNA as an Effector to Modulate Gene Regulation
Authors: Kreuzer Kiel D. , Henkin Tina M. 
Published: July 2018

ABSTRACT

The T-box riboswitch is a unique, RNA-based regulatory mechanism that modulates expression of a wide variety of amino acid-related genes, predominantly in
Firmicutes
. RNAs of this class selectively bind a specific cognate tRNA, utilizing recognition of the tRNA anticodon and other tRNA features. The riboswitch monitors the aminoacylation status of the tRNA to induce expression of the regulated downstream gene(s) at the level of transcription antitermination or derepression of translation initiation in response to reduced tRNA charging via stabilization of an antiterminator or antisequestrator. Recent biochemical and structural studies have revealed new features of tRNA recognition that extend beyond the initially identified Watson-Crick base-pairing of a codon-like sequence in the riboswitch with the tRNA anticodon, and residues in the antiterminator or antisequestrator with the tRNA acceptor end. These studies have revealed new tRNA contacts and new modes of riboswitch function and ligand recognition that expand our understanding of RNA-RNA recognition and the biological roles of tRNA.
Steaming through the Ordovician, Knoxville, Tennessee
Authors: Capito C. Howard , Drumheller Stephanie , Hatcher Robert D. 
Published: July 2018

ABSTRACT
This field guide highlights the Paleozoic geology of the Knoxville, Tennessee, area, framed in the context of the historic, halcyon days of Knox County’s marble industry and the railroads built to serve the area’s many limestone quarries and mills. The Three Rivers Rambler excursion train (the “Rambler”) is pulled by an 1890 “Consolidation” steam locomotive, which has been restored and is now operated by the Knoxville & Holston River Railroad Co., Inc. The Rambler route follows the north bank of the Tennessee River; passes through a sequence of Lower and Middle Ordovician carbonates, shales, and sandstones of the Knox and Chickamauga Groups; crosses the High Bridge at the confluence of the Holston and French Broad Rivers; and ends near Marbledale Quarry before returning to Knoxville. The two geologic groups are dominated by carbonates and lie in the syncline that contained most of the commercial marble that was quarried in the Knoxville area for the past 150 years. Exposures of the Holston Formation, a limestone commercially referred to as Holston [M]arble, were excavated to build the railroad ~125 years ago. It is possible to observe four of the seven formations making up the Knox and Chickamauga Groups along the route, but the outcrops are not accessible during typical railroad operations or by automobile. Arrangements were made for a field trip during the 2018 Geological Society of America Southeastern Section meeting, and this guide provides details for four selected exposures between Knoxville and the Forks of the River Marble District, with three optional stops. Only during the field trip, passengers will be able to disembark the train to examine carbonate and shale outcrops, structures, and discuss facies relationships of the foreland basin bryozoan reef deposits along the western flank of the Taconic (Sevier) foredeep. In addition to the local geology, this field guide describes the key role of railroads in the development of the Knox County marble industry, the history of what is today the Knoxville & Holston River Railroad, a corporate descendent of the 1887 Knoxville Belt Railroad Company, and the Tennessee Marble industry.
Mesoscale faults, macroscale folds, and inferred basement structures, Nashville dome, central Tennessee
Authors: Abolins Mark , Bush Rachel , Han Amber , Ogden Albert 
Published: July 2018

ABSTRACT
This guide explores relationships among macroscale folds, mesoscale structures, the Nashville dome, and an inferred Precambrian or Cambrian rift in the basement beneath the dome. The Nashville dome, central Tennessee, is an ~12,000 km2 north-northeast–trending, elliptical cratonic uplift. A published crustal density model shows that a previously undescribed Precambrian or Cambrian rift, herein named the Nashville rift, probably runs from northwestern Alabama through the Nashville dome to southern Kentucky. Within the Nashville dome, macroscale folds and mesoscale structures of the Stones River and Harpeth River fault zones have been interpreted previously as the surface manifestation of subsurface normal faults. This road guide describes two previously undescribed inferred subsurface fault zones: the Marshall Knobs fault zone and the Northern Highland Rim fault zone. The Marshall Knobs fault zone, which is ~16.3 km long, is associated with ~35 m of structural relief, trends east-southeast, is down on the north side, and is inside the geophysically defined rift. The Northern Highland Rim fault zone consists of east-northeast–­striking minor normal and reverse faults and a minor strike-slip fault exposed above the western margin of the geophysically defined rift. The authors hypothesize that the Northern Highland Rim fault zone may be the surface manifestation of the subsurface continuation of a macroscale fault previously mapped at the surface 25 km to the southwest. All of the inferred faults fit into a tectonic model in which they originally formed within a rift and later reactivated, accommodating extension of the uppermost crust during uplift of the Nashville dome.
Evolution of the Blue Ridge basement complex in the eastern Great Smoky Mountains: Evidence from zircon U-Pb geochronology and Nd-Pb isotope geochemistry of basement gneisses
Authors: Moecher D.P. , Anderson E.D. , Loughry D.F. , Quinn R.J. , Larkin E.A. , Walsh K.B. , Samson S.D. , Satkoski A.M. , Tohver E. 
Published: July 2018

ABSTRACT
The eastern Great Smoky Mountains basement complex consists of the following components: (1) ca. 1350–1325 Ma orthogneiss and mafic xenoliths that represent some of the oldest crust in Appalachian Grenville massifs (similar to “pre-Grenville” basement components in the Adirondack, Green Mountain, Hudson Highland, and Shenandoah massifs); (2) ca. 1150 Ma augen orthogneisses and granitic orthogneisses correlating with the Shawinigan phase of Grenville magmatism; and (3) paragneisses (cover rocks) that have either pre- or syn-Grenville (i.e., Mesoproterozoic) versus post-Grenville (Neoproterozoic) depositional ages, and that experienced Taconian metamorphism and migmatization. Mesoproterozoic paragneisses contain major zircon age modes that require a component of Proterozoic crust in the source region. The Neoproterozoic paragneisses exhibit the archetypical “Grenville doublet” in detrital zircon age distributions that matches the age distribution of Ottawan and Shawinigan magmatic/metamorphic events in eastern Laurentia. Most zircon U-Pb age systematics exhibit variable lead loss interpreted to result from high-grade Taconian (ca. 450 Ma) regional metamorphism and migmatization. Neodymium mantle model ages (TDM) for ortho- and paragneisses range from 1.8 to 1.6 Ga, indicating that all rocks were derived from recycling of Proterozoic crust (i.e., they are not juvenile), which is consistent with Proterozoic detrital zircon ages in pre- to syn-Grenville paragneisses. Lead isotope compositions confirm the presence of an exotic (Amazonian) crustal component in the source region for the protoliths of the pre-Grenville orthogneisses and xenoliths, and that this exotic component was incorporated to varying degrees in the evolution of the basement complex. The oldest age component may represent an Amazonian pre-Grenville analog to the ca. 1.35 Ga native Laurentian crust present in Adirondack and northern Appalachian basement massifs.
Analysis of a large cohort of non-small cell lung cancers submitted for somatic variant analysis demonstrates that targeted next-generation sequencing is fit for purpose as a molecular diagnostic assay in routine practice
Authors: Moore David Allan , Balbi Kevin , Ingham Alexander , Arkenau Hendrik-Tobias , Bennett Philip 
Published: July 2018

AimsTargeted next-generation sequencing (tNGS) is increasingly being adopted as an alternative to single gene testing in some centres. Our aim was to assess the overall fitness and utility of tNGS as a routine clinical test in non-small cell lung cancer (NSCLC).MethodsAll NSCLC cases submitted to a single laboratory for tNGS analysis over a 3-year period were included. Rejection/failure rates and turnaround times were calculated. For reportable cases, data relating to observed genetic changes likely to be driving tumour growth and/or contributing to therapeutic resistance were extracted. The impact of varied referral site practices (tissue processing and sample format submitted) on analytical outcomes was also considered.ResultsA total of 2796 cases were submitted, of which 217 (7.8%) were rejected and 131 (5.1%) failed. The median turnaround time was seven working days. Of 2448 reported cases, KRAS, EGFR or other recognised driver mutations were observed in 35%, 17% and 5.4%, respectively. Of the remaining cases, 3.5% demonstrated significant incidental evidence of gene amplification. In 15% of EGFR-driven cases, evidence of an EGFR tyrosine kinase inhibitor resistance mechanism was observed. Potential concerns around the provision of slides or precut ‘rolls’ only (cf, formalin fixed paraffin embedded (FFPE) tissue blocks) as standard practice by certain referral sites were identified.ConclusionsA tNGS panel approach is practically achievable, with acceptable success rates and turnaround times, in the context of a routine clinical service. Furthermore, it provides additional clinically and analytically relevant information, which is not available from single gene testing alone.
Racial disparities in renal function: the role of racial discrimination. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Authors: Camelo Lidyane V , Giatti Luana , Ladeira Roberto Marini , Griep Rosane Harter , Mill José Geraldo , Chor Dóra , Barreto Sandhi Maria 
Published: July 2018

BackgroundRacial discrimination may play a significant role in higher incidence and poorer prognosis of chronic kidney disease among Black individuals. This study set out to investigate the association between racial discrimination and renal function and to estimate the contribution of racial discrimination to existing racial disparities in renal function.MethodsA cross-sectional analysis using baseline data (2008–2010) of 14 355 participants (35–74 years) in the Brazilian Longitudinal Study of Adult Health cohort study. Renal function was estimated based on estimated glomerular filtration rates (eGFR) obtained by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Racial discrimination was assessed using a modified version of the Lifetime Major Events Scale ; race/colour was self-reported. Covariates included were age, sex, level of education and selected health-related factors.ResultsRacial discrimination was reported by 31.6%, 6.3% and 0.8% of Black, Brown and White individuals, respectively. The older the age, the lower the prevalence of racial discrimination among Blacks. Racial discrimination was independently associated with lower mean eGFR (β=−2.38; 95% CI −3.50 to −1.25); however, associations were limited to individuals aged under 55 years. In this age group, eGFR differences between Black and White individuals were reduced by 31% when exposure to racial discrimination was accounted for.ConclusionBlacks are approximately 40 times more likely to report racial discrimination than Whites. Racial discrimination was associated with lower mean eGFR and explained a significant portion of eGFR differences between Black and White individuals aged under 55 years. Exposure to experiences of racial discrimination should be accounted for in studies investigating racial disparities in renal function.
Exploring the impact of hydrostatic pressure on the structural, electronic and mechanical properties of ZrNiPb half-Heusler alloy: A DFT approach
Authors: Babalola M. I. , Adetunji B. I. , Iyorzor B. E. , Yaya A. 
Published: July 2018

The structural, electronic, elastic and mechanical properties of ZrNiPb half-Heusler alloy under pressure ranging from 0 to 25 GPa have been studied using the density functional theory within the generalized gradient approximation (GGA). The results of ambient condition were in good agreement with the available theoretical and experimental data. Our electronic structure and density of state results show that ZrNiPb is an indirect bandgap semiconductor half-Heusler alloy with a narrow energy gap of 0.375 eV. Based on the calculated elastic constants (C[Formula: see text], C[Formula: see text] and C[Formula: see text]), Young’s modulus (E), Poisson’s ratio ([Formula: see text]), Shear modulus (G), Zener anisotropy factor (A) and brittle-ductile behaviors under pressure have been discussed. The calculated Poisson’s ratio shows that ZrNiPb undergoes a relatively small volume change during uniaxial deformation. We show that the chemical bonds in ZrNiPb are stronger due to the high value of C[Formula: see text].
A tale of two rift shoulders, and two ice masses: the Cryogenian glaciated margin of Death Valley, California
Authors: Le Heron D. P. , Busfield M. E. , Ali D. O. , Vandyk T. , Tofaif S. 
Published: July 2018

Abstract
The Death Valley area of California, USA, exposes an outstanding record of a Neoproterozoic (Cryogenian) glaciated margin: the Kingston Peak Formation. Despite the quality of the exposure, however, the outcrops of glaciogenic strata are fragmentary, forming isolated, laterally offset outcrop belts at the western extremity of the Basin and Range province. Excellent evidence for glacially modulated sedimentation includes (1) ice-rafted dropstones in most ranges, (2) thick diamictites bearing a variety of exotic (extrabasinal) clasts, (3) striated clasts and (4) local occurrences of glacitectonic deformation structures at the basin margins. In tandem with this, there is a distinct signature of slope collapse processes in many ranges, including (1) up to kilometre-scale olistoliths, (2) extensional growth fault arrays, (3) dramatic proximal-distal thickness changes and (4) basalt occurrences. New sedimentological observations reinforce long-held views of rifting superimposed on glaciation (or vice versa), with both processes contributing to a complex record whereby rift and glacial processes vie for stratigraphic supremacy. We consider that a mechanism of diamictite accumulation in a series of rift-shoulder minibasins produced greatly contrasting successions across the Death Valley area, under the incontrovertible influence of hinterland ice sheets.
Methodology for Assessing Mesh-Based Contact Point Methods
Authors: Erleben Kenny 
Published: July 2018

Computation of contact points is a critical sub-component of physics-based animation. The success and correctness of simulation results are very sensitive to the quality of the contact points. Hence, quality plays a critical role when comparing methods, and this is highly relevant for simulating objects with sharp edges. The importance of contact point quality is largely overlooked and lacks rigor and as such may become a bottleneck in moving the research field forward.
We establish a taxonomy of contact point generation methods and lay down an analysis of what normal contact quality implies. The analysis enables us to establish a novel methodology for assessing and studying quality for mesh-based shapes. The core idea is based on a test suite of three complex cases and a small portfolio of simple cases. We apply our methodology to eight local contact point generation methods and conclude that the selected local methods are unable to provide correct information in all cases. The immediate benefit of the proposed methodology is a foundation for others to evaluate and select the best local method for their specific application. In the longer perspective, the presented work suggests future research focusing on semi-local methods.
Location-aware Influence Maximization over Dynamic Social Streams
Authors: Wang Yanhao , Li Yuchen , Fan Ju , Tan Kian-Lee 
Published: July 2018

Influence maximization (IM), which selects a set of
k
seed users (a.k.a.,
a seed set
) to maximize the influence spread over a social network, is a fundamental problem in a wide range of applications. However, most existing IM algorithms are static and location-unaware. They fail to provide high-quality seed sets efficiently when the social network evolves rapidly and IM queries are location-aware. In this article, we first define two IM queries, namely
Stream Influence Maximization
(SIM) and
Location-aware SIM
(LSIM), to track influential users over social streams. Technically, SIM adopts the sliding window model and maintains a seed set with the maximum influence value collectively over the most recent social actions. LSIM further considers social actions are associated with
geo-tags
and identifies a seed set that maximizes the influence value in a query region over a location-aware social stream. Then, we propose the
Sparse Influential Checkpoints
(SIC) framework for efficient SIM query processing. SIC maintains a sequence of
influential checkpoints
over the sliding window and each checkpoint maintains a partial solution for SIM in an append-only substream of social actions. Theoretically, SIC keeps a logarithmic number of checkpoints w.r.t. the size of the sliding window and always returns an approximate solution from one of the checkpoint for the SIM query at any time. Furthermore, we propose the
Location-based SIC
(LSIC) framework and its improved version LSIC
+
, both of which process LSIM queries by integrating the SIC framework with a Quadtree spatial index. LSIC can provide approximate solutions for both ad hoc and continuous LSIM queries in real time, while LSIC
+
further improves the solution quality of LSIC. Experimental results on real-world datasets demonstrate the effectiveness and efficiency of the proposed frameworks against the state-of-the-art IM algorithms.
Mucosal HPV E6/E7 Peptide Vaccination in Combination with Immune Checkpoint Modulation Induces Regression of HPV+ Oral Cancers
Authors: Dorta-Estremera Stephanie , Chin Renee L. , Sierra Gloria , Nicholas Courtney , Yanamandra Ananta V. , Nookala Sita M.K. , Yang Guojun , Singh Shail , Curran Michael A. , Sastry K. Jagannadha 
Published: July 2018

Abstract
High-risk human papillomavirus (HPV)–associated squamous cell carcinomas of the oropharynx (SCCOP) are among the fastest growing cancers. After standard-of-care treatment, however, patients with HPV+ SCCOP have better overall and disease-specific survival than patients with HPV− SCCOP, suggesting the importance of HPV-specific immunity. We reasoned that therapeutic vaccination targeting the HPV-16 E6 and E7 oncogenes could elicit high-affinity, high-frequency tumor antigen–specific T-cell responses, which could then be augmented and shielded from suppression in the tumor microenvironment by immune checkpoint modulation. In this study, we used a preclinical syngeneic mouse model of oral cancer comprised of mouse tonsil-derived epithelial cells stably expressing HPV-16 E6 and E7 genes along with H-ras oncogene (mEER) to identify combinations of vaccination and checkpoint antibodies capable of promoting tumor regression. Intranasal HPV E6/E7 peptide vaccination and single checkpoint antibodies failed to elicit responses in more than half of animals; however, 4-1BB agonist antibody along with either CD40 agonist antibody or CTLA-4 blockade eliminated the majority of established mEER tumors. The combination of intranasal HPV peptide vaccine and α4-1BB and αCTLA-4 antibodies produced curative efficacy and a better safety profile against orally implanted mEER tumors. Correlates of protective immunity included enhanced intratumoral levels of CD8 T cells relative to immunosuppressive regulatory T cells and myeloid-derived suppressor cells. Overall, our results demonstrate combination vaccine-immunotherapy modalities as novel treatment options for HPV+ SCCOP.
Significance: Combinations of vaccine and checkpoint modulation are effective and safe treatment options for HPV+ oral cancers. Cancer Res; 78(18); 5327–39. ©2018 AACR.
A Biological Signature for Breast Ductal Carcinoma In Situ to Predict Radiotherapy Benefit and Assess Recurrence Risk
Authors: Bremer Troy , Whitworth Pat W. , Patel Rakesh , Savala Jess , Barry Todd , Lyle Stephen , Leesman Glen , Linke Steven P. , Jirström Karin , Zhou Wenjing , Amini Rose-Marie , Wärnberg Fredrik 
Published: July 2018

Abstract

Purpose:
Ductal carcinoma in situ (DCIS) patients and their physicians currently face challenging treatment decisions with limited information about the individual's subsequent breast cancer risk or treatment benefit. The DCISionRT biological signature developed in this study provides recurrence risk and predicts radiotherapy (RT) benefit for DCIS patients following breast-conserving surgery (BCS).

Experimental Design:
A biological signature that calculates an individualized Decision Score (DS) was developed and cross-validated in 526 DCIS patients treated with BCS ± RT. The relationship was assessed between DS and 10-year risk of invasive breast cancer (IBC) or any ipsilateral breast event (IBE), including IBC or DCIS. RT benefit was evaluated by risk group and as a function of DS.

Results:
The DS was significantly associated with IBC and IBE risk, HR (per 5 units) of 4.2 and 3.1, respectively. For patients treated without RT, DS identified a Low Group with 10-year IBC risk of 4% (7% IBE) and an Elevated Risk Group with IBC risk of 15% (23% IBE). In analysis of DS and RT by group, the Elevated Risk Group received significant RT benefit, HR of 0.3 for IBC and IBE. In a clinicopathologically low-risk subset, DS reclassified 42% of patients into the Elevated Risk Group. In an interaction analysis of DS and RT, patients with elevated DS had significant RT benefit over baseline.

Conclusions:
The DS was prognostic for risk and predicted RT benefit for DCIS patients. DS identified a clinically meaningful low-risk group and a group with elevated 10-year risks that received substantial RT benefit over baseline.