bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-time behavior of random and nonautonomous Fisher-KPP equations. Part II. Transition fronts
Authors: Salako Rachidi B. , Shen Wenxian 
Published: March 2019

In the current series of two papers, we study the long-time behavior of the following random Fisher-KPP equation: [Formula: see text] where [Formula: see text], [Formula: see text] is a given probability space, [Formula: see text] is an ergodic metric dynamical system on [Formula: see text], and [Formula: see text] for every [Formula: see text]. We also study the long-time behavior of the following nonautonomous Fisher-KPP equation: [Formula: see text] where [Formula: see text] is a positive locally Hölder continuous function. In the first part of the series, we studied the stability of positive equilibria and the spreading speeds of (1.1) and (1.2). In this second part of the series, we investigate the existence and stability of transition fronts of (1.1) and (1.2). We first study the transition fronts of (1.1). Under some proper assumption on [Formula: see text], we show the existence of random transition fronts of (1.1) with least mean speed greater than or equal to some constant [Formula: see text] and the nonexistence of random transition fronts of (1.1) with least mean speed less than [Formula: see text]. We prove the stability of random transition fronts of (1.1) with least mean speed greater than [Formula: see text]. Note that it is proved in the first part that [Formula: see text] is the infimum of the spreading speeds of (1.1). We next study the existence and stability of transition fronts of (1.2). It is not assumed that [Formula: see text] and [Formula: see text] are bounded above and below by some positive constants. Many existing results in literature on transition fronts of Fisher-KPP equations have been extended to the general cases considered in the current paper. The current paper also obtains several new results.
Elevated Heme Synthesis and Uptake Underpin Intensified Oxidative Metabolism and Tumorigenic Functions in Non–Small Cell Lung Cancer Cells
Authors: Sohoni Sagar , Ghosh Poorva , Wang Tianyuan , Kalainayakan Sarada Preeta , Vidal Chantal , Dey Sanchareeka , Konduri Purna Chaitanya , Zhang Li 
Published: March 2019

Abstract

Tumors of human non–small cell lung cancer (NSCLC) are heterogeneous but exhibit elevated glycolysis and glucose oxidation relative to benign lung tissues. Heme is a central molecule for oxidative metabolism and ATP generation via mitochondrial oxidative phosphorylation (OXPHOS). Here, we showed that levels of heme synthesis and uptake, mitochondrial heme, oxygen-utilizing hemoproteins, oxygen consumption, ATP generation, and key mitochondrial biogenesis regulators were enhanced in NSCLC cells relative to nontumorigenic cells. Likewise, proteins and enzymes relating to heme and mitochondrial functions were upregulated in human NSCLC tissues relative to normal tissues. Engineered heme-sequestering peptides (HSP) reduced heme uptake, intracellular heme levels, and tumorigenic functions of NSCLC cells. Addition of heme largely reversed the effect of HSPs on tumorigenic functions. Furthermore, HSP2 significantly suppressed the growth of human NSCLC xenograft tumors in mice. HSP2-treated tumors exhibited reduced oxygen consumption rates (OCR) and ATP levels. To further verify the importance of heme in promoting tumorigenicity, we generated NSCLC cell lines with increased heme synthesis or uptake by overexpressing either the rate-limiting heme synthesis enzyme ALAS1 or uptake protein SLC48A1, respectively. These cells exhibited enhanced migration and invasion and accelerated tumor growth in mice. Notably, tumors formed by cells with increased heme synthesis or uptake also displayed elevated OCRs and ATP levels. These data show that elevated heme flux and function underlie enhanced OXPHOS and tumorigenicity of NSCLC cells. Targeting heme flux and function offers a potential strategy for developing therapies for lung cancer.

Significance:
These findings show that elevated heme availability due to increased heme synthesis and uptake causes intensified oxygen consumption and ATP generation, promoting tumorigenic functions and tumor growth in NSCLC.
The Dark Side of Innate Immunity Fosters Tumor Growth and Offers New Diagnostic
Authors: Carbone Ennio 
Published: March 2019

Abstract
So far, the tumor's immune landscape has been related mainly to the adaptive immune cell infiltrate. The possibility of using tumor-infiltrating innate immune cells as the source for prognostic markers and their role in immune checkpoint therapy have been neglected. Unraveling these aspects may lead to new immune therapy interventions.
See related article by Duan et al., p. 3304
Conversations in Context: Cross-Cultural (Grassroots) Biblical Interpretation Groups Challenging Western-centric (Professional) Biblical Interpretation
Authors: John Helen C. 
Published: March 2019

Abstract
This article considers how biblical scholarship might break out of its western-dominated, largely historical-critical mould. I argue that we might challenge the hegemony of ‘western worldview’ scholarship by capitalising on the interpretative insights of alternative worldviews; in that regard, I advance a cross-cultural methodology. Additionally, I advocate engaging with grassroots interpreters, thereby contributing to the decentring of scholarly biblical criticism. Finally, this article focuses on the value of interpretation through dialogue, which functions here on two levels: the researcher dialoguing with grassroots interpretation groups in cross-cultural settings, and the resulting grassroots interpretations dialoguing with western professional biblical interpretations. The potential of this approach is demonstrated using a case study: Mark 4:35-41 interpreted with Cross-Cultural Biblical Interpretation Groups in northern Namibia. The interpretative insights of grassroots groups in non-western contexts, free(r) from the influence of western worldviews and scholarship, function to highlight the equally contextual nature of mainstream professional biblical interpretation.
The Threat of Empire: Monstrous Hybridity in Revelation 13
Authors: Macumber Heather 
Published: March 2019

Abstract
The Apocalypse of John is filled with monsters who threaten both spatial and cultural boundaries. They are generally understood as ciphers for the Roman Empire and its ­rulers. Rather than seeking the ancient Near Eastern origins of the monstrous imagery, the intent of this paper is to use monster theory to better understand why John employs monsters throughout the apocalypse. I argue that the author’s portrayal of the threat and punishment of hybrid monsters reveals his own insecurities and fears concerning his communities’ assimilation with Roman culture. John uses monsters specifically to target rival prophets in his communities that espouse a different vision of living under Rome rule.
Redescription of three Italian species of Labronema Thorne, 1939 (Dorylaimida: Dorylaimidae)
Authors: Peña-Santiago Reyes , Vinciguerra Maria Teresa 
Published: March 2019

Summary
This contribution presents a redescription of three Labronema species originally described from Italy: L. angeloi, L. carusoi and L. pulchrum. Their type material is re-examined, described and illustrated with line drawings and micrographs. New information about these species is provided, including morphometrics and relevant morphological features. Morphologically, the three species form a homogeneous group, but can be separated by significant differences in the structure of female genital system, cuticle thickness on the tail, and shape and size of the spicules. Labronema pulchrum is regarded as a junior synonym of L. duhouxi.
Ghana-Korea Economic Relations – The Record after 40 Years and the Future
Authors: Adu Amoah Lloyd G. , Asante Kwasi 
Published: March 2019

Abstract
Over the last sixty years the economic and industrial fortunes of Ghana and Korea have proved worryingly divergent. Though Ghana and South Korea had comparatively similar GDP per capita in the 1960s, South Korea in 20171 ($29,742.839) has been able to attain a GDP per capita that is about ten times that of Ghana ($1,641.487). This work critically examines the economic relationship between Ghana and South Korea in the last forty years. It focuses on the economic miracle of South Korea and the lessons for developing countries like Ghana. The article utilizes economic, historical and policy data drawn from primary and secondary sources in an attempt to examine the economic relations between the two countries thus far and prescribe ways in which Ghana can benefit far more than ever before from her economic co-operation with Korea. The paper argues that for Ghana to benefit from its economic relations with South Korea the ideational example of this East Asian state in constructing a developmental state (DS) is critical. Flowing from this, it is recommended that this West African nation becomes more diligent and innovative in her economic relations with Korea as a matter of strategic necessity in pursuit of Ghana’s long held industrialization dream.
What’s in a Duty? EU Identification of Non-cooperating Port States and Their Prescriptive Responses
Authors: Honniball Arron N. 
Published: March 2019

Abstract
Council Regulation (EC) No 1005/2008 provides that a third country may be identified and subject to measures if it fails “to discharge the duties incumbent upon it under international law as flag, port, coastal or market state, to take action to prevent deter and eliminate IUU fishing”. In assessing the promise or limits of this unilateral listing mechanism, the question arises as to what influence, if any, it has had on third-country legislation. This article uses a case study on port state duties, demonstrating the use and impact of the unilaterally defined port state duties and their implementation in EU practice. The latter part addresses trends in the prescriptive responses of port states, including whether the EU listing process was a contributing factor to legislative reform. Prescriptive trends highlighted are the implementation of generally accepted treaty-based port state measures, followed by three examples of expansion into port state offences.
The Role of International Investment Law in the Business and Human Rights Legal Process
Authors: Chiussi Ludovica 
Published: March 2019

Abstract
This article examines the interplay between international investment law and international human rights law in order to assess whether the former can be used to foster corporate accountability for violations of human rights. The role of international investment agreements in ensuring corporate compliance with human rights will be addressed, together with the approach to human rights violations of corporations by international investment tribunals. Whilst acknowledging some inherent limits of IIL, the underling argument of the paper is that rebalancing rights and obligations of investors may give teeth to corporate human rights accountability, while also benefitting the legitimacy of IIL.
The Rehabilitation of Philosophy via Hermeneutics. Maimonides’ Diverging Scriptural Evidence Regarding the Quest for the Rationale of the Commandments
Authors: Seidler Meir 
Published: March 2019

Abstract
This article focuses on one of the central issues in Moses Maimonides’ Jewish philosophy: the quest for the rationale of the commandments. Maimonides regards this quest as religiously obligatory. However, on two occasions he points to diverging scriptural evidence to underline his claim. By juxtaposing the two different scriptural proofs adduced by Maimonides, his use of hermeneutics in the service of philosophy is exposed in the inner precincts of Judaism: in regard to Judaism’s particularistic law. In terms of spiritual leadership, Maimonides’ dual scriptural approach enables him to bring his philosophical message home to different audiences.
Externalism about Artifactual Words and the Taxonomy of Artifacts
Authors: Marconi Diego 
Published: March 2019

Putnam and others have argued that semantic externalism extends to artifactual kind words such as “pencil” or “doorstop”. I first show that, even with natural kinds, externalism applies (at best) to words for ground level kinds. The issue then arises of which categories of artifacts should be identified as kinds in the relevant, restricted sense. I argue that, though there are natural taxonomies of artifactual categories at least some of which have well-defined ground levels, even words for such kinds do not appear to have externalist semantics, as they do not support ignorance or error arguments. Some think that membership to any kind is determined by objective features. Against this, I argue that the makers’ productive intentions are often crucial in selecting which pattern of features counts as constitutive of a kind. Though externalists may insist that membership to a kind is ultimately determined by sharing objective features, the resulting version of externalism can hardly be distinguished from internalism.
Media, Public Scholarship and Religious Controversy: Notes from Trump’s America
Authors: Hoover Stewart M. 
Published: March 2019

Abstract
The persistence of religion in the twenty-first century has renewed the importance of scholarships devoted to it. At the same time, the digital age has re-positioned and recentered the affordances of mediated circulations around "the religious." This increasing presence and significance of media and religion suggests that substantive scholarships of religion must necessarily articulate media as well. Religious controversies therefore present a special challenge and a special opportunity to scholarships of media and religion. New ways of doing scholarship, and doing so publicly, present themselves. All scholarships of mediated religion must necessarily be public, so scholarship is articulated into these circulations, and at the same time can build on and benefit from knowledge-building that occurs outside the formal boundaries of the academy. This paper explores emerging theories of digital mediation and proposes a circulation-focused understanding of the role, place, and potentials of scholarships today.
Is an Atheist Religion in Austria Legally Possible?
Authors: Apfalter Wilfried 
Published: March 2019

Abstract
In the face of widespread opinion holding that atheism is somehow necessarily separated from religion and opposed to it, the question “Is an atheist religion in Austria legally possible?” is both intriguing and challenging, leading to the cutting edge of contemporary studies on law, religion, and state. By providing a close, focused view on the legal framework concerning an example case in the Republic of Austria, the present article revisits this widespread opinion. It argues that this opinion can be challenged from a legal point of view in at least one concrete case, namely that of a growing group of atheists who try to establish an officially accepted, state-registered religious denominational community of atheists: Atheistische Religionsgesellschaft in Österreich (Atheist Religious Society in Austria), or arg for short. The article discusses this case and concludes that an atheist religion is legally possible in Austria.
Measuring Multisensory Imagery of Wine: the Vividness of Wine Imagery Questionnaire
Authors: Croijmans Ilja , Speed Laura J. , Arshamian Artin , Majid Asifa 
Published: March 2019

Abstract
When we imagine objects or events, we often engage in multisensory mental imagery. Yet, investigations of mental imagery have typically focused on only one sensory modality — vision. One reason for this is that the most common tool for the measurement of imagery, the questionnaire, has been restricted to unimodal ratings of the object. We present a new mental imagery questionnaire that measures multisensory imagery. Specifically, the newly developed Vividness of Wine Imagery Questionnaire (VWIQ) measures mental imagery of wine in the visual, olfactory, and gustatory modalities. Wine is an ideal domain to explore multisensory imagery because wine drinking is a multisensory experience, it involves the neglected chemical senses (smell and taste), and provides the opportunity to explore the effect of experience and expertise on imagery (from wine novices to experts). The VWIQ questionnaire showed high internal consistency and reliability, and correlated with other validated measures of imagery. Overall, the VWIQ may serve as a useful tool to explore mental imagery for researchers, as well as individuals in the wine industry during sommelier training and evaluation of wine professionals.
China and the UNCLOS: Practices and Policies
Authors: Ma Xinmin 
Published: March 2019

Abstract
The 1982 United Nations Convention on the Law of the Sea (UNCLOS or the Convention) is one of the most important accomplishments in the development of international law in the twentieth century. As a comprehensive compilation of the modern law of the sea, the UNCLOS not only codifies numerous customary rules of law of the sea, but also progressively develops the treaty rules of law of the sea. Especially the three bodies established by the UNCLOS, namely the International Seabed Authority (ISA), the International Tribunal for the Law of the Sea (ITLOS) and the Commission on the Limits of the Continental Shelf (CLCS), have played an important role in facilitating the implementation of the UNCLOS and promoting stability and development of the international marine order. As a member of the big family of the States Parties to the UNCLOS, China has been faithfully fulfilling the obligations of the UNCLOS, fully engaged in the work of the three bodies and actively contributing its solutions and wisdom. In the process of implementing the UNCLOS, China has formed its own practices and policies.
Subsampling Impact on the Climate Change Signal over Poland Based on Simulations from Statistical and Dynamical Downscaling
Authors: Mezghani Abdelkader , Dobler Andreas , Benestad Rasmus , Haugen Jan Erik , Parding Kajsa M. , Piniewski Mikolaj , Kundzewicz Zbigniew W. 
Published: March 2019

ABSTRACTMost impact studies using downscaled climate data as input assume that the selection of few global climate models (GCMs) representing the largest spread covers the likely range of future changes. This study shows that including more GCMs can result in a very different behavior. We tested the influence of selecting various subsets of GCMs on the climate change signal over Poland from simulations based on dynamical and empirical–statistical downscaling methods. When the climate variable is well simulated by the GCM, such as temperature, results showed that both downscaling methods agree on a warming over Poland by up to 2° or 5°C assuming intermediate or high emission scenarios, respectively, by 2071–2100. As a less robust simulated signal through GCMs, precipitation is expected to increase by up to 10% by 2071–2100 assuming the intermediate emission scenario. However, these changes are uncertain when the high emission scenario and the end of the twenty-first century are of interest. Further, an additional bootstrap test revealed an underestimation in the warming rate varying from 0.5° to more than 4°C over Poland that was found to be largely influenced by the selection of few driving GCMs instead of considering the full range of possible climate model outlooks. Furthermore, we found that differences between various combinations of small subsets from the GCM ensemble of opportunities can be as large as the climate change signal.
Submesoscale Vortical Wakes in the Lee of Topography
Authors: Srinivasan Kaushik , McWilliams James C. , Molemaker M. Jeroen , Barkan Roy 
Published: March 2019

AbstractAn idealized framework of steady barotropic flow past an isolated seamount in a background of constant stratification (with frequency N) and rotation (with Coriolis parameter f) is used to examine the formation, separation, instability of the turbulent bottom boundary layers (BBLs), and ultimately, the genesis of submesoscale coherent vortices (SCVs) in the ocean interior. The BBLs generate vertical vorticity ζ and potential vorticity q on slopes; the flow separates and spawns shear layers; barotropic and centrifugal shear instabilities form submesoscale vortical filaments and induce a high rate of local energy dissipation; the filaments organize into vortices that then horizontally merge and vertically align to form SCVs. These SCVs have O(1) Rossby numbers () and horizontal and vertical scales that are much larger than those of the separated shear layers and associated vortical filaments. Although the upstream flow is barotropic, downstream baroclinicity manifests in the wake, depending on the value of the nondimensional height , which is the ratio of the seamount height to that of the Taylor height , where L is the seamount half-width. When , SCVs span the vertical extent of the seamount itself. However, for , there is greater range of variation in the sizes of the SCVs in the wake, reflecting the wake baroclinicity caused by the topographic interaction. The aspect ratio of the wake SCVs has the scaling , instead of the quasigeostrophic scaling .
Retreating to the History of Judicial Review?
Authors: Aronson Mark 
Published: March 2019

AbstractLess than a decade ago, the High Court said, in effect, that State Supreme Courts have substantially the same entrenched jurisdiction to issue relief in the nature of the prerogative writs as the Constitution confers on the High Court. The New South Wales Court of Appeal reads this narrowly, holding that only three specific remedies are protected, together with the rules and limitations that existed at federation. If correct, we might see the emergence of two bodies of doctrine, the old law of remedies and the new law of ‘judicial review’ (a concept that emerged only after federation). In an unrelated case, six High Court judges implied a limited privative clause ousting non-jurisdictional certiorari. The seventh judge said that this was unnecessary, because in his view, that branch of certiorari conflicts with judicial review fundamentals, is historically misconceived, and should apply only where the reviewing court can try the matter afresh. This article reviews these developments, discusses their rationales and questions both the history and its importance.
Do radiologists detect chronic thromboembolic disease on computed tomography?
Authors: Rogberg Anna Nordgren , Gopalan Deepa , Westerlund Eli , Lindholm Peter 
Published: March 2019

Background Chronic thromboembolic pulmonary hypertension (CTEPH), a complication of acute pulmonary embolism, is a potentially curable form of pulmonary hypertension (PH). CTEPH is under-diagnosed for a number of reasons leading to delayed referral or missed diagnosis; however, the frequency of misdiagnosis of CTEPH findings on computed tomography (CT) is currently unknown. Purpose To evaluate the extent of misdiagnosis of CTEPH on CT. Material and Methods We studied the original CT reports from 35 patients with confirmed CTEPH diagnosis referred to a specialist center for pulmonary endarterectomy during 2011–2016. The patients’ CT reports were assessed according to a standardized form and compared to a consensus reading by two expert radiologists. Results The expert reading identified all CTEPH cases. However, in the original reports, the terminology “CTEPH” was only used in two patients. Another seven descriptive reports picked up the combination of PH and vascular signs of CTEPH without making a definitive diagnosis. Taking these nine cases as positive for CTEPH, the overall sensitivity on a diagnostic level was 26%. Pulmonary arterial abnormalities were described in isolation in 63% with no mention of PH or CTEPH. Signs of PH and mosaic attenuation were documented in 53% and 6% of the original reports, respectively, where it could be seen on the CT examination. Conclusion The study shows that radiologists frequently miss CTEPH findings, leading to a falsely low sensitivity for CT. There was also a notable discrepancy in how the findings were presented in radiology reports.