bluuebunny/crossref_metadata_2025_split huggingface dataset:
Felicidade e religião em Freud: uma leitura crítica
Authors: Firmino Carlos Eduardo 
Published: February 2019

O presente trabalho visa discutir a relação estabelecida por Freud entre religião e felicidade. Para tanto, utilizaremos como principal referência o ensaio O mal-estar na cultura, publicado em 1930. Neste ensaio, a partir do questionamento a respeito do "sentimento oceânico", assim nomeado por Romain Rolland, Freud insiste que a suposta felicidade disponível ao crente é resultado de um processo delirante de submissão. Em troca de algum alívio para seu sofrimento, o homem religioso se mantém numa eterna posição de infantilismo. Como possibilidade de superação de tal neurose infantil, Freud sugere um tipo de "educação para a realidade", na qual aprenderíamos a utilizar nossas energias na vida terrena, tornando a convivência humana mais suportável e, consequentemente, menos opressoras as regulações da cultura. Ao final, abordaremos a aposta religiosa como um recurso de felicidade, na medida em que ela, tal como a ciência defendida por Freud, é oriunda dos desejos do crente. Nesse sentido, discutiremos a plausibilidade da proposta freudiana de educação, e também se a religião, de fato, merece ser rechaçada ao modo escolhido pelo pai da psicanálise.
Hemiepiphysiodesis using tension band plates: Does the initial screw angle influence the rate of correction?
Authors: Eltayeby H. H. , Iobst C. A. , Herzenberg J. E. 
Published: February 2019

Purpose When using tension band plates for angular deformity correction, the literature is unclear regarding the most effective screw insertion angle to use. This study evaluates the correlation between initial screw angle and the average rate of correction during hemiepiphysiodesis using tension band plates Methods This retrospective study includes 35 patients (47 physes) with genu valgum deformity (17 idiopathic and 18 fibular hemimelia) who underwent insertion of Eight-Plates between 2010 and 2015. Initial screw angle was determined from the intraoperative fluoroscopic images. Radiographs were obtained within three months of surgery, and follow-up films were obtained every three to six months. Change in mechanical lateral distal femoral angle, medial proximal tibial angle and screw angle was obtained from each follow-up radiograph. Initial screw angle was correlated with the average rate of correction during the entire treatment period. The average rate of angular correction during first and last follow-up periods was also compared. Results The relationship between the initial screw angle and the mean rate of angular correction was not statistically significant (p = 0.2). The rate of angular correction during the first follow-up period (mean of 4.7 months) was 0.86° per month compared with 0.71° per month during the last follow-up period (mean of 5.1 months). Conclusion Application of a tension band plate with a divergence angle ranging from 0° to 30° results in similar rates of angular correction. For surgeons inserting screw-plate tension band devices, there does not seem to be any necessity to make the screws parallel or divergent. We recommend that screw placement be anatomically correct, i.e. not impinging on the physis, rather than favouring any particular divergence angle. Level of evidence IV
The reliability of full-length lower limb radiographic alignment measurements in skeletally immature youth
Authors: Schmale G. A. , Bayomy A. F. , O'Brien A. O. , Bompadre V. 
Published: February 2019

Purpose Reliable radiographic measurement techniques are important for investigating limb alignments prior to and following paediatric anterior cruciate ligament (ACL) reconstruction. We investigated the inter- and intraobserver reliability of alignment measurements from lower extremity anteroposterior and lateral radiographs of adolescents having undergone transphyseal ACL reconstruction Methods A total of 15 of 90 patients who had undergone transphyseal ACL reconstruction were randomly selected for alignment measurements of radiographs of operative and nonoperative limbs. Radiographs were de-identified, randomized to three varying sequences and made available in electronic format to three blinded investigators: a junior orthopaedic resident, a senior orthopaedic resident and a paediatric orthopaedic attending. Coronal measurements comprised the mechanical lateral distal femoral angle (mLDFA), mechanical medial proximal tibial angle (mMPTA) and mechanical axis deviation (MAD), measured from standing teleoroentgenograms of the lower extremities. Tibial slope was measured on lateral knee radiographs of operative limbs. The intra-class correlation coefficient (ICC) was calculated for each of the three coronal measures and for tibial slope. Results Intraobserver reliability was excellent across all measures (ICC > 0.75) except for tibial slope in one investigator's measurements (good or ICC = 0.68 for the operative limbs) and mLDFA in another investigator's measurements (fair or ICC = 0.49 for the operative limbs, and poor ICC = 0.27 for the nonoperative limbs). Interobserver reliability was excellent across all investigators for all measurements for operative and nonoperative limbs. Conclusions Radiographic measurements of lower extremity alignment may be reliably measured on teleoroentgenograms in a subset of youth who underwent transphyseal ACL reconstruction. Level of Evidence III
Clinical Utility of Mutant Antibody-Based Assays for Determination of Internally Cleaved and Intact Forms of Free Prostate-Specific Antigen
Authors: Khan Md. Ferdhos L , Soikkeli Minna , Routila Erica , Krannila Sandra , Terävä Joonas , Taimen Pekka , Boström Peter J , Pettersson Kim 
Published: February 2019

Abstract

Background
Subforms of prostate-specific antigen (PSA) have been a subject of intensive research, and use of multikallikrein immunoassays can add clinical value to the early detection of prostate cancer, overcoming known limitations of PSA. In this study, we evaluated mutant 4D4 (L3-2) antibody-assisted assay constructs against reference wild-type (wt)-4D4-based assays for determination of intact PSA (iPSA) and nicked PSA (nPSA) in plasma samples.

Methods
Perioperative plasma samples obtained from 105 men who underwent biopsy (73 cancer, 32 noncancer) were analyzed with sandwich immunoassays for total PSA (tPSA), free PSA (fPSA), iPSA (3 constructs), and measured nPSA (2 constructs). Calculated nPSA (CN) was obtained from total fPSA − iPSA.

Results
Mutant-assisted iPSA assays measured lower concentrations than the reference in both patient groups. CN separated the 2 groups with the iPSA using the mutant for capture (I-MC) performing the best (P = 0.008). In prostate volume group &gt; median, only measured nPSA provided significant discrimination [area under the curve (AUC), 0.71; P = 0.016] but equally using mutant and wt antibodies. In the whole cohort, all ratios to tPSA performed well (AUC, 0.819–0.870; P ≤ 0.0001) with CN based on I-MC scoring highest (AUC, 0.870). Importantly, in the ≤ median volume group, the I-MC/F and CN(I-MC)/T ratios stand out as the best performing parameters (AUC, 0.825 and 0.861; P = 0.001 and P = 0.0003, respectively).

Conclusions
The new assay construct using the mutant 4D4 (L3-2) as a capture provides clear improvement in separating cancer from noncancer in all subgroups analyzed but especially in patients with prostate volume ≤ median.
Clinical Trial Registration: ClinicalTrials.gov Identifier NCT01864135.
An Efficient Storage System for Adult Odonata Specimens, With Application for Other Museum Collections
Authors: Blades David C. A. , Copley Claudia , Lee Kasey 
Published: February 2019

Abstract
A new system of storing adult Odonata (damselfly and dragonfly) specimens is described and compared to existing storage systems. The major design innovation is the use of tongue and groove (“zipper lock”) resealable polyethylene envelopes manufactured to fit the standard index card and specimen arrangement currently used in major collections. Other design improvements include low-cost, adhesive-free specimen trays and glass-top drawers built to fit in standard-dimension Cornell insect cabinets. Comparisons of materials and designs with other available systems are presented and discussed. Finally, examples are presented of this new system's applicability to other collections such as Lepidoptera and Archeology.
The Transformative Power of Student-Led Natural History Collections Clubs
Authors: Gerdes Cheyenne , Harris Kari M , Beas-Moix Mireia , Marsico Travis D 
Published: February 2019

Abstract
Many colleges and universities maintain herbaria or natural history collections. Natural History Collections Clubs (NHCCs) are registered student organizations (RSOs) capable of improving conditions in these collections, many of which are threatened by a lack of funding, minimal curatorial staff, and inadequate institutional support. Student involvement through NHCCs can improve conditions in collections at academic institutions by providing volunteers, promoting outreach, increasing funding, and generating enthusiasm in administration, students, and the community. In this paper, we explain the need for such organizations, outline the process of establishing an NHCC, and provide case studies from successful organizations. We also describe a developing network for NHCCs and summarize what has been accomplished by these organizations to date.
On Process Management (PM) The applicability of Michael Hammer’s theory in Argentina
Authors: Bello Hernán , Viltard Leandro Adolfo 
Published: February 2019

This article explores the applicability of Hammer’s theories on Operational Innovation (OI), Operational Excellence (OE) and processes, on firms of different industrial sectors and sizes, located in Argentina. The hypothesis of this study -which was corroborated- suggests that the manager’s role is supported by what is called Process Management (PM), which deals with performance gaps in a given period of time. In this context, OE, OI and processes’ understanding becomes an important constituent of the management activity. Through the implementation of a holistic PM-based perspective in many more organizations it is possible to boost results, achieve superior levels of performance and offer the right customer value. Specifically, a process is represented by a sequence of activities. It allows installing, following and measuring an operation, and isbased on five enablers and four capabilities that are explained in this study. This is an exploratory and descriptive work, with a qualitative methodology. Also, this study has a not experimental/transversal design. It is based on Hammer’s theories on the matter, which were complemented with executives/managers' interviews of different multinationals and local firms located in Argentina. debt crowdfunding in Latin America and Mexico. Implications for lenders, researchers and policy-makers are also discussed.
Deep venous thrombosis of lower limbs in adolescents: a study in a tertiary hospital
Authors: Faria Catarina , Antunes Henedina , Pontes Teresa , Antunes Ana , Martins Sofia , Carvalho Susana 
Published: February 2019

Abstract

Background
Venous thromboembolism (VTE) – which includes deep venous thrombosis (DVT) and pulmonary embolism (PE) – has been increasingly recognized in the pediatric population. The estimated incidence is 0.07–0.14 cases per 10,000 children. Most cases are associated with two or more risk factors. Medium and long-term complications include recurrence and post-thrombotic syndrome (PTS).

Objective
To characterize the adolescent population with the diagnosis of DVT of lower limbs in a tertiary hospital, regarding its clinical presentation, associated risk factors, treatment and outcome.

Methods
Retrospective analysis of adolescents with the diagnosis of DVT of lower limbs in our hospital for a period of 7 years.

Results
Eight patients were identified; seven were females; median age was 15 years. The main symptoms were local pain and edema. Left lower limb was affected in six patients. PE occurred in two cases. Positive family history of venous thromboembolism was found in five patients. Seven patients had at least two identifiable risk factors. Combined oral contraceptive pill use was the most common (seven patients). Factor V Leiden mutation was found in three patients and protein C deficiency in one. Iliac vein compression syndrome was diagnosed in one patient. The median time for discharge was 8 days. Election treatment was enoxaparin followed by warfarin, for a median period of 10.9 months. Three patients developed PTS.

Conclusions
Although uncommon, VTE is an emerging reality in adolescents, particularly in females using oral contraceptive pills. Appropriated prevention strategies and treatment are required as most orientations are extrapolated from adults.
Crystal structure of ajacisine D monohydrate, C30H44N2O9
Authors: Li Guo-Qiang , Xu Qing-Peng , Zhao Yi-Ting , Li Yun-Yi , Li Yao-Lan , Wang Guo-Cai 
Published: February 2019

Abstract
C30H44N2O9, monoclinic, P21 (no. 4), a = 7.9827(3) Å, b = 12.6787(6) Å, c = 14.0183(9) Å, β = 90.903(5)°, V = 1418.62(13) Å3, Z = 2, R
gt(F) = 0.0607, wR
ref(F
2) = 0.1298, T = 298(2) K.
Theoretical analysis of LC-refining – pressure screening systems in TMP
Authors: Rubiano Berna Jorge Enrique , Sandberg Christer , Martinez Mark , Olson James 
Published: February 2019

Abstract
LC refining of mechanical pulps has proven to save energy in the production of TMP pulps. However, the specific role of LC refining as part of a TMP system has not been thoroughly studied since it is difficult to conceive any particular system at industrial-scales and impractical at pilot-scales. In this study, pressure screening and LC refining models that describe fibre length distributions, together with correlations to predict refining power were used to model three basic refining systems. From the simulation results, the impact of important variables such as reject ratio, refiner gap and refining net-power was studied. Performance curves of length-weighed average fibre length were generated from simulation results and were used to assess each system behaviour and also to make comparisons between systems. Data from an industrial scale TMP mill sub-system was gathered and compared to simulation results showing relative errors between 0–18 % on the predicted variables.
Effect of nobiletin on experimental model of epilepsy
Authors: Yang Baowang , Wang Jing , Zhang Ni 
Published: February 2019

AbstractBackgroundThe effects of nobiletin, a plant-derived flavonoid was examined against pentylenetetrazole (PTZ)-induced seizures. The study also aimed to assess whether nobiletin potentiated the effects of antiepileptic drug clonazepam (CZP).MethodsPTZ (92 mg/kg, subcutaneous) was used to induce seizures in mice. Treatment groups (n = 18/group) received nobiletin (12.5, 25, or 50 mg/kg) via oral gavage for 6 consecutive days and 45 min prior to PTZ injection. CZP (0.015-2.0 mg/kg) was administered 15 min prior to PTZ. Skeletal muscle strength was assessed by measuring grip strength and Chimney test was performed to study the motor performance in animals. TUNEL assay was done to study neuro-apoptosis. RT-PCR and Western blot analysis were performed for assessment of mRNA and protein expressions.ResultsNobiletin and CZP improved muscle strength and motor coordination and reduced seizure severity significantly. The administration of nobiletin and CZP, individually or in combination, downregulated seizure-induced increases in apoptotic cell count and apoptotic protein expression, modulated the expression of gamma-aminobutyric acid (GABA)A and glutamate decarboxylase 65 and restored the glutamate/GABA balance. Nobiletin and CZP administration significantly upregulated phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling.ConclusionNobiletin exerted protective effect against seizures by regulating signaling pathways associated with epileptogenesis and potentiated the effects of CZP.
Eye Position Error Influence over “Open-Loop” Smooth Pursuit Initiation
Authors: Buonocore Antimo , Skinner Julianne , Hafed Ziad M. 
Published: February 2019

The oculomotor system integrates a variety of visual signals into appropriate motor plans, but such integration can have widely varying time scales. For example, smooth pursuit eye movements to follow a moving target are slower and longer lasting than saccadic eye movements and it has been suggested that initiating a smooth pursuit eye movement involves an obligatory “open-loop” interval in which new visual motion signals presumably cannot influence the ensuing motor plan for up to 100 ms after movement initiation. However, this view is contrary to the idea that the oculomotor periphery has privileged access to short-latency visual signals. Here, we show that smooth pursuit initiation is sensitive to visual inputs, even in open-loop intervals. We instructed male rhesus macaque monkeys to initiate saccade-free smooth pursuit eye movements and injected a transient, instantaneous eye position error signal at different times relative to movement initiation. We found robust short-latency modulations in eye velocity and acceleration, starting only ∼50 ms after transient signal occurrence and even during open-loop pursuit initiation. Critically, the spatial direction of the injected position error signal had predictable effects on smooth pursuit initiation, with forward errors increasing eye acceleration and backward errors reducing it. Catch-up saccade frequencies and amplitudes were also similarly altered ∼50 ms after transient signals, much like the well known effects on microsaccades during fixation. Our results demonstrate that smooth pursuit initiation is highly sensitive to visual signals and that catch-up saccade generation is reset after a visual transient.SIGNIFICANCE STATEMENTSmooth pursuit eye movements allow us to track moving objects. The first ∼100 ms of smooth pursuit initiation are characterized by smooth eye acceleration and are overwhelmingly described as being “open-loop”; that is, unmodifiable by new visual motion signals. We found that all phases of smooth pursuit, including the so-called open-loop intervals, are reliably modifiable by visual signals. We injected transient flashes resulting in very brief, spatially specific position error signals to smooth pursuit and observed very short-latency changes in smooth eye movements to minimize such errors. Our results highlight the flexibility of the oculomotor system in reacting to environmental events and suggest a functional role for the pervasiveness of visual sensitivity in oculomotor control brain regions.
Successful Use of Quality Improvement Methodology to Reduce Inpatient Length of Stay in Bronchiolitis Through Judicious Use of Intermittent Pulse Oximetry
Authors: Mittal Shraddha , Marlowe Lauren , Blakeslee Samantha , Zieniuk Gregory , Doshi Samir , Gray Bobbi Jo , Bowen Melissa , Oleaga Leslie , Carbone Kelly , Aumaier Brenna L. , Taylor April , Joffe Mark 
Published: February 2019

BACKGROUND AND OBJECTIVES:
The American Academy of Pediatrics 2014 bronchiolitis guidelines recommend against the routine use of continuous pulse oximetry (CPO) because it has been implicated in prolonging the length of stay (LOS). At our institution, infants admitted with bronchiolitis were monitored by using CPO during the entire hospital stay and intermittent desaturations &lt;90% appeared to delay discharge. This quality improvement initiative was designed to reduce the LOS by decreasing the use of CPO in stable infants with nonsevere bronchiolitis.

METHODS:
The quality improvement project was implemented on the inpatient units of 2 community hospitals during the 2016 and 2017 bronchiolitis seasons. In cycle 1 (January 2016 to April 2016), the bronchiolitis pathway from the associated quaternary children’s hospital was used to (1) limit the use of CPO to patients with severe bronchiolitis and those at high risk for apnea or severe disease, (2) discontinue CPO as patients improved and stabilized, and (3) standardize discharge criteria. In cycle 2 (November 2016 to April 2017), the clinical pathway was adopted. The main outcome measure was LOS, measured from the time of the admission order to the time of the discharge order. Process measures included compliance with the interventions.

RESULTS:
The project included 373 patients, 180 preintervention and 193 postintervention. The average LOS decreased by 20 hours, from 53 hours at baseline to 33 hours in cycle 2. No adverse events were noted, and there was no significant change in the number of emergency department revisits and readmissions within 7 days.

CONCLUSIONS:
In our study, LOS was successfully reduced in bronchiolitis patients by using a clinical pathway that limited CPO to patients with severe bronchiolitis and those at risk for severe disease or apnea.
Adolescent Reproductive Health Care: Views and Practices of Pediatric Hospitalists
Authors: Masonbrink Abbey R. , Stancil Stephani , Reid Kimberly J. , Goggin Kathy , Hunt Jane Alyce , Mermelstein Sarah J. , Shafii Taraneh , Lehmann Amber G. , Harhara Haleema , Miller Melissa K. 
Published: February 2019

BACKGROUND AND OBJECTIVES:
Many hospitalized adolescents are at increased risk for pregnancy complications due to an underlying medical condition, however sexual risk assessment is not consistently performed in this setting. While adolescents and their parents are supportive of sexual health discussion in the inpatient setting, a thorough understanding of factors that influence provision of this care among pediatric hospital physicians is lacking. This formative information is needed to facilitate efforts to improve and standardize clinical care provision. Our objective is to assess the frequency and factors that influence the provision of adolescent sexual and reproductive care by pediatric hospitalists.

METHODS:
We performed a cross-sectional computerized survey of hospitalists at 5 pediatric hospitals who cared for ≥1 adolescent (14–21 years old) in the past year. Sexual and reproductive care practices were assessed by using a 76-item novel survey informed by the theory of planned behavior. We used descriptive statistics to summarize the data.

RESULTS:
Sixty-eight pediatric hospitalists participated (49% response rate): 78% were women and 65% were aged &lt;40 years. Most (69%) reported treating &gt;46 adolescents annually, including many who are at an increased risk for pregnancy complications due to teratogenic medication use or a comorbid condition. A majority felt that sexual and reproductive services are appropriate, although many endorsed barriers, including concern about follow-up after emergency contraception (63%) and time constraints (53%). Most reported insufficient knowledge regarding contraception (59%), desired contraception education (57%), and were likely to increase contraceptive provision if provided education (63%). Hospitalists rarely provided condoms or referral for an intrauterine device.

CONCLUSIONS:
Pediatric hospitalists frequently care for adolescents who are at risk for pregnancy complications and generally agree that reproductive care is appropriate in the inpatient setting. With these findings, we highlight the critical need for effective comprehensive reproductive health service interventions that are tailored to address the numerous actionable barriers identified in this study.