bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels
Authors: Osimo Emanuele Felice , Baxter Luke James , Lewis Glyn , Jones Peter B. , Khandaker Golam M. 
Published: July 2019

AbstractBackgroundPeripheral low-grade inflammation in depression is increasingly seen as a therapeutic target. We aimed to establish the prevalence of low-grade inflammation in depression, using different C-reactive protein (CRP) levels, through a systematic literature review and meta-analysis.MethodsWe searched the PubMed database from its inception to July 2018, and selected studies that assessed depression using a validated tool/scale, and allowed the calculation of the proportion of patients with low-grade inflammation (CRP >3 mg/L) or elevated CRP (>1 mg/L).ResultsAfter quality assessment, 37 studies comprising 13 541 depressed patients and 155 728 controls were included. Based on the meta-analysis of 30 studies, the prevalence of low-grade inflammation (CRP >3 mg/L) in depression was 27% (95% CI 21–34%); this prevalence was not associated with sample source (inpatient, outpatient or population-based), antidepressant treatment, participant age, BMI or ethnicity. Based on the meta-analysis of 17 studies of depression and matched healthy controls, the odds ratio for low-grade inflammation in depression was 1.46 (95% CI 1.22–1.75). The prevalence of elevated CRP (>1 mg/L) in depression was 58% (95% CI 47–69%), and the meta-analytic odds ratio for elevated CRP in depression compared with controls was 1.47 (95% CI 1.18–1.82).ConclusionsAbout a quarter of patients with depression show evidence of low-grade inflammation, and over half of patients show mildly elevated CRP levels. There are significant differences in the prevalence of low-grade inflammation between patients and matched healthy controls. These findings suggest that inflammation could be relevant to a large number of patients with depression.
Internalizing and externalizing psychopathology in middle age: genetic and environmental architecture and stability of symptoms over 15 to 20 years
Authors: Gustavson Daniel E. , Franz Carol E. , Panizzon Matthew S. , Lyons Michael J. , Kremen William S. 
Published: July 2019

AbstractBackgroundInternalizing and externalizing psychopathology factors explain much of the covariance among psychiatric conditions, especially at the level of genetic risk. However, few studies have examined internalizing and externalizing factors in middle-aged samples, especially their ability to predict later symptoms across midlife. The goals of the current study were (i) to quantify the genetic and environmental influences on internalizing and externalizing psychopathology in individuals in their early 40s, and (ii) examine the extent to which these genetic and environmental influences predict self-reported measures of internalizing and externalizing symptoms 15–20 years later.Method1484 male twins completed diagnostic interviews of psychopathology at mean age 41 and self-reported measures of anxiety, depression, substance use, and related variables at up to two time-points in late middle age (mean ages 56 and 62).ResultsStructural equation modeling of the diagnostic interviews confirmed that internalizing and externalizing factors accounted for most of the genetic variance in individual disorders, with substantial genetic (ra = 0.70) and environmental (re = 0.77) correlations between the factors. Internalizing psychopathology at age 41 was correlated with latent factors capturing anxiety, depression, and/or post-traumatic stress symptoms at ages 56 (r = 0.51) and 62 (r = 0.43). Externalizing psychopathology at age 41 was correlated r = 0.67 with a latent factor capturing aggression, tobacco use, and alcohol use at age 56. Stability of both factors was driven by genetic influences.ConclusionsThese findings demonstrate the considerable stability of internalizing and externalizing psychopathology symptoms across middle age, especially their genetic influences. Diagnostic interviews effectively predict self-reported symptoms and behaviors 15–20 years later.
Association of PTSD symptom groups with functional impairment and distress in trauma-exposed disaster survivors
Authors: North Carol S. , Van Enkevort Erin , Hong Barry A. , Surís Alina M. 
Published: July 2019

AbstractBackgroundIn the nearly a quarter of a century since the addition of the clinically significant distress/impairment criterion to the definition of PTSD in DSM-IV, little research has been done to examine the association of this criterion with symptom group criteria and with the numbing subgroup specifically. This study was conducted to examine these relationships in a large database of disaster survivors consistently studied across 12 different incidents of the full range of disaster typology.MethodsAnalysis was conducted on a merged database representing 1187 trauma-exposed survivors of 12 different disasters studied systematically. DSM-IV-TR criteria for disaster-related PTSD were assessed with the Diagnostic Interview Schedule.ResultsPTSD Group C (avoidance/numbing) and numbing specifically were less common and more associated than other symptom groups with criterion F (distress/impairment). Consistently in multivariable models, group C and numbing were independently associated with criterion F. Group D (hyperarousal) was less strongly associated with criterion F. Neither group B (intrusion) nor avoidance were associated with criterion F.ConclusionsIn this and other studies, group C and numbing specifically have been shown to be associated with criterion F, which is consistent with the demonstration that group C and the numbing component specifically are central to the psychopathology of PTSD. The addition of the distress/impairment requirement broadly across the psychiatric diagnoses in DSM-IV added little value to PTSD symptom criteria. Future revisions of diagnostic criteria may benefit by carefully considering these findings to possibly re-include a prominent numbing symptom section.
Metabolism, bioenergetics and thermal physiology: influences of the human intestinal microbiota
Authors: Armstrong Lawrence E. , Casa Douglas J. , Belval Luke N. 
Published: July 2019

AbstractThe micro-organisms which inhabit the human gut (i.e. the intestinal microbiota) influence numerous human biochemical pathways and physiological functions. The present review focuses on two questions, ‘Are intestinal microbiota effects measurable and meaningful?’ and ‘What research methods and variables are influenced by intestinal microbiota effects?’. These questions are considered with respect to doubly labelled water measurements of energy expenditure, heat balance calculations and models, measurements of RMR via indirect calorimetry, and diet-induced energy expenditure. Several lines of evidence suggest that the intestinal microbiota introduces measurement variability and measurement errors which have been overlooked in research studies involving nutrition, bioenergetics, physiology and temperature regulation. Therefore, we recommend that present conceptual models and research techniques be updated via future experiments, to account for the metabolic processes and regulatory influences of the intestinal microbiota.
Primary Health Care Nurses’ Self-Perception of Theoretical Knowledges and Practical Skills in Life-Threatening Emergencies: A Cross-Sectional Study
Authors: Cernuda Martínez José Antonio , Castro Delgado Rafael , Cuartas Álvarez Tatiana , Arcos González Pedro 
Published: July 2019

AbstractBackground:Within out-of-hospital emergencies, primary health care (PHC) nurses must face life-threatening emergencies (LTEs), which are defined as “a situation associated with an imminent life risk that entails the start-up of resources and special means to resolve the situation.”Objectives:The objectives of this study were to know the training received for out-of-hospital LTEs by PHC nurses of Asturias, Spain and the perception they have about their theoretical knowledge and practical skills in a series of emergency procedures or techniques used in LTE emergencies; as well as to analyze the differences according to the geographical area of their work.Design:Cross-sectional, descriptive, and observational study was conducted in 2018 of a sample of PHC service nurses of Asturias, Spain.Methods:A total of 236 nurses from PHC service centers of Asturias, Spain, from among the total of 730 nurses who make up the staff of nurses of the PHC service of Asturias, between April and May 2018, were surveyed. The survey was designed ad hoc using the Doctrinal Body of Emergency Nursing (DBEN) proposed by the Spanish Society of Emergency Medicine (SEMES; Madrid, Spain), which indicates the theoretical and practical procedures that must be acquired by the PHC nurses. It is composed of 37 procedures or techniques employed in LTEs using an 11-point Likert scale rating to detect their self-perception about theoretical knowledge and practical skills from zero (“Minimum”) to ten (“Maximum”).Results:There were significant differences in the mean of theoretical knowledge and practical skills in many procedures or techniques studied, depending on the different areas of work.Conclusions:All PHC nurses must be perfectly trained to provide initial quality assistance to the LTE, with both theoretical and practical knowledge of the different techniques, so that it can continue to be attended by the corresponding Emergency Service.
Dosimetric comparison of volumetric modulated arc therapy and intensity modulated radiation therapy for anal cancer
Authors: Chiang Bing-Hao , Hibbitts Kerry , Ortega Heather , Herman Terence , Ahmad Salahuddin 
Published: July 2019

AbstractAim:Volumetric modulated arc therapy (VMAT), an extension of intensity modulated radiation therapy (IMRT), employs modifications in gantry rotation speed, machine dose rate and multi-leaf collimator motion to deliver a three-dimensional dose distribution. This study compared VMAT to IMRT for patients with anal carcinoma.Materials and Methods:Sixteen patients previously treated with IMRT were retrospectively selected. Each patient received a total dose of 57·6–63·0 Gy in 1·8 Gy fractions. A single- or double-isocenter multi-arc VMAT treatment plan was generated using Eclipse RapidArc system with the same computed tomography image sets and optimisation constraints used for IMRT. Dose–volume histograms (DVHs) for planning target volumes (PTVs) and organs at risk (OARs), and monitor units (MUs) and beam on times (BOTs) were used for comparison.
Results:IMRT and VMAT plans showed insignificant differences in PTV homogeneity and conformity and sparing hips and bowel. VMAT required fewer mean MU and shorter BOT per plan (1,597 MU, 2·66 min) compared to IMRT (2,571 MU, 4·29 min) with p < 0·0001.
Conclusions:Fewer MU and shorter BOT for VMAT may decrease the damage from secondary radiation and treatment delivery uncertainty due to intra-fraction tumour motion, leading to higher machine throughput and improving patient comfort, with less treatment time.
The burden of preventable hospitalizations before and after implementation of the health transformation plan in a hospital in west of Iran
Authors: Piroozi Bakhtiar , Amerzadeh Mohammad , Safari Hossein , Mohamadi-Bolbanabad Amjad , Afkhamzadeh Abdorrahim , Zarezadeh Yadolah , Mahmoudi Javad , Salavati Sedigheh 
Published: July 2019

Abstract

Background:
Increased number of preventable hospitalizations (PHs) for ambulatory care sensitive conditions (ACSCs) represents less efficiency and low access to outpatient and primary health care, leading to waste of health system resources.

Aim:
The purpose of this study is to assess the quality of outpatient and primary health care using the rate of PHs for ACSCs and to estimate the economic burden of ASCS before and after the implementation of the health transformation plan (HTP) in Iran.

Methods:
This research was a before–after quasi-experimental study. The study population included all patients hospitalized in the largest general hospital of Kurdistan province with five diseases such as asthma, diabetes, hypertension, congestive heart failure, and chronic obstructive pulmonary disease in 2014 (before the implementation of the HTP) and 2015 (after the implementation of the HTP). Data were analyzed by SPSS v.20 using Chi-square test.

Findings:
Total number of hospitalizations before and after the implementation of the HTP was 1501 and 1405, respectively. Moreover, the proportion of PHs in all types of the hospital admissions before and after the implementation of the HTP was 47% and 49%, respectively. There was no statistically significant difference between the number of PHs before and after the HTP. In total, PHs imposed 885 798 US$ and 9920 bed-days on health system before and after the implementation of the HTP.

Conclusion:
Despite the previous expectations of policy makers for improving quality, efficiency, and access to primary health care through implementation of the HTP, proportion of PHs is considerable and it imposes a lot of costs and bed-days on the health system both before and after the HTP.
Developing planetary sustainability: Legal challenges of Space 4.0
Authors: Bohlmann Ulrike M. , Petrovici Gina 
Published: July 2019

Non-technical abstractSixty years of space activities have led to ongoing scientific and technological progress. Space 4.0 reflects the rapid changes of the space community. Growing interest in space activities leads to increasing participation of numerous new actors in this field. Governments, private actors and international organizations are eager to fill existing gaps in securing global society's needs. The European Space Agency's Space 4.0 concept is designed to host a new era of space activities, aiming to resolve global challenges and to serve society. Space 4.0 developments are highly important, but are taking place in an extremely complex net of legal, regulatory and political considerations. This paper focuses on the legal challenges raised by the new era of Space 4.0 in a sustainability context.
Adherence to Alternative Healthy Eating Index (AHEI-2010) is not associated with risk of stroke in Iranian adults: A case-control study
Authors: Mousavi Seyed Mohammad , Milajerdi Alireza , Pouraram Hamed , Saadatnia Mohammad , Shakeri Forough , Keshteli Ammar Hassanzadeh , Tan Shing Cheng , Esmaillzadeh Ahmad 
Published: July 2019

Abstract. Background: Stroke is a major global health problem that contributes to a significant burden of morbidity and mortality. The association of several foods and nutrients with stroke has been well-established. However, the effect of the whole diet on stroke is poorly understood. In this work, we aimed to examine the association between the quality of whole diet, as measured using Alternate Healthy Eating Index-2010 (AHEI-2010), and risk of stroke in Iranian adults. Methods: In this hospital-based case-control study, 193 stroke patients (diagnosed based on clinical and brain CT findings) and 193 controls with no history of cerebrovascular diseases or neurologic disorders were included. The participants’ dietary intakes were examined using a validated 168-item semi-quantitative food frequency questionnaire. AHEI-2010 was constructed based on earlier studies. Participants were classified according to tertiles of AHEI-2010 scores and multivariate logistic regression was used to evaluate the association between whole diet quality and risk of stroke. Results: Individuals with greater adherence to AHEI-2010 had a higher intake of fruits, vegetables, nuts and legumes, whole grains and carbohydrate, and a lower intake of trans-fatty acids, sugar-sweetened beverages, total energy and fat (P < 0.05). After adjusting for potential confounders, adherence to AHEI-2010 was not significantly associated with a reduced risk of stroke (OR: 0.92; 95% CI: 0.56–1.51). Conclusion: We found that adherence to AHEI-2010 was not associated with risk of stroke in Iranian adults. Further prospective studies are warranted to validate this finding and clarify the relationship between whole diet and stroke.
Numerical Representations of Marine Ice‐Nucleating Particles in Remote Marine Environments Evaluated Against Observations
Authors: McCluskey C. S. , DeMott P. J. , Ma P.‐L. , Burrows S. M. 
Published: July 2019

AbstractThe abundance and sources of ice‐nucleating particles, particles required for heterogeneous ice nucleation, are long‐standing sources of uncertainty in quantifying aerosol‐cloud interactions. In this study, we demonstrate near closure between immersion freezing ice‐nucleating particle number concentration (nINPs) observations and nINPs calculated from simulated sea spray aerosol and dust. The Community Atmospheric Model with constrained meteorology was used to simulate aerosol concentrations at the Mace Head Research Station (North Atlantic) and over the Southern Ocean to the south of Tasmania (Clouds, Aerosols, Precipitation, Radiation, and atmospherIc Composition Over the southeRN ocean campaign). Model‐predicted nINPs were within a factor of 10 of nINPs observed with an off‐line ice spectrometer at Mace Head Research Station and Clouds, Aerosols, Precipitation, Radiation, and atmospherIc Composition Over the southeRN ocean campaign, for 93% and 69% of observations, respectively. Simulated vertical profiles of nINPs reveal that transported dust may be critical to nINPs in remote regions and that sea spray aerosol may be the dominate contributor to primary ice nucleation in Southern Ocean low‐level mixed‐phase clouds.
Deformation of Ionospheric Potential Pattern by Ionospheric Hall Polarization
Authors: Nakamizo Aoi , Yoshikawa Akimasa 
Published: July 2019

AbstractThe present study shows that the ionospheric Hall polarization can deform the high‐latitude ionospheric convection field, which is widely considered to be a manifestation of the convection field in the magnetosphere. We perform the Hall polarization field separation with a potential solver by changing the conductance distribution step by step from a uniform one to a more realistic one. We adopt dawn‐dusk and north‐south symmetric distributions of conductance and region 1 (R1) field‐aligned current (FAC). The pair of the primary field of the R1 system and each gradient of off‐diagonal component of conductance tensor (Hall conductance) generates the Hall polarization field and consequently causes potential deformations as follows. (a) The equatorward gradient causes clockwise rotation. (b) The gradient across the terminator, together with the effect of the equatorward gradient, causes the dawn‐dusk asymmetry. (c) The high conductance band in the auroral region causes kink‐type deformations. In particular, a nested structure at the equatorward edge of the band in the midnight sector well resembles the Harang Reversal. Result (a) can explain the clockwise bias inexplicable by the IMF‐By effect alone, the combination of (a) and (b) can explain the clearness and unclearness in the round or crescent shapes of the dawn‐dusk cells depending on the IMF‐By polarity, and (c) suggests that the ionosphere may not need the upward‐FAC for the formation of the Harang Reversal. We suggest that the final structure of the ionospheric potential is established by the combined effects of the magnetospheric requirements (external causes) and ionospheric polarization (internal effect).
Remotely Sensing Variation in Ecological Strategies and Plant Traits of Willows in Perialpine Floodplains
Authors: Milani G. , Kneubühler M. , Tonolla D. , Doering M. , Wiesenberg G. L. B. , Schaepman M. E. 
Published: July 2019

AbstractNatural floodplains are characterized by a complex habitat mosaic. However, damming, water storage, and hydropower production affect many floodplains by altering their natural habitat diversity. Field sampling data and imaging spectroscopy are used in combination with statistical models to assess resource allocation strategies of willow stands in perialpine floodplains. Three contrasting floodplain reaches located along two rivers in Switzerland serve as test beds: The Sarine River is partitioned into an upstream and downstream segment under the influence of a dam and a hydropower plant, while the Sense River represents an undisturbed, natural floodplain. Airborne imaging spectrometer data allow mapping of spatially distributed Competitor/Stress tolerator/Ruderal (CSR) strategies using a partial least square modeling approach. Using cross validation, we demonstrate that a statistical modeling approach can reveal variations in CSR scores based on the StrateFy model. Such intraspecific variation of CSR scores cannot be captured by a strategy categorization based solely on the species. Results reveal that willows shifted toward more competition and less stress tolerance along hydrologically altered reaches compared to the willows strategy along the natural control. Moreover, the overall distribution of strategies indicates that stress factors (i.e., limiting growth factors), rather than disturbance (i.e., events leading to partial or total destruction), shape the plant traits of alluvial willow trees. Detailed assessments of resource allocation strategies contribute to a more complete understanding of the continuous and reciprocal shaping between flow regimes, landforms, and alluvial vegetation.
Rate of Slip From Multiple Quaternary Dating Methods and Paleoseismic Investigations Along the Talas‐Fergana Fault: Tectonic Implications for the Tien Shan Range
Authors: Rizza M. , Abdrakhmatov K. , Walker R. , Braucher R. , Guillou V. , Carr A. S. , Campbell G. , McKenzie D. , Jackson J. , Aumaître G. , Bourlès D. L. , Keddadouche K. 
Published: July 2019

AbstractThe ~400‐km‐long Talas‐Fergana Fault is one of a series of major right‐lateral strike‐slip faults that cross the Tien Shan Range. This fault has been recognized as active in the late Holocene and accommodates part of the deformation induced by the ongoing Indo‐Asian collision. The kinematics and the role of this strike‐slip fault are poorly understood with no large earthquakes reported in the instrumental or historical catalogs, and no well‐constrained geological slip‐rate estimates. Here we used high‐resolution satellite imagery to present a first detailed analysis of the fault segmentation. We identified nine geometric segments based on strike variations for the Talas‐Fergana Fault. Along the Kyldau segment, through morphological analyses of an offset alluvial fan and the application of multiple dating methods (10Be,26Al,36Cl, luminescence, and radiocarbon), we calculated a late Quaternary slip rate ranging from 2.2 to 6.3 mm/year. This rate is higher than the geodetic measurements, but the discrepancy can be partly explained if the Talas‐Fergana Fault accommodates shortening by counterclockwise rotation around a vertical axis. Paleoearthquakes identified by trenching indicate that at least two primary surface ruptures (and possibly a third) occurred in the past 3,800 years, and that no large earthquake has ruptured the Kyldau segment since at least 420 years B.P. (possibly within the last 2,700 years), making this fault segment a potential candidate to generate an earthquake withM> 7 in the near future.