bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potent Anticoagulation Does Not Reduce Venous Thromboembolism in High-Risk Patients
Authors: Tan Timothy L. , Foltz Carol , Huang Ronald , Chen Antonia F. , Higuera Carlos , Siqueira Marcelo , Hansen Erik N. , Sing David C. , Parvizi Javad 
Published: April 2019

Background:
Based on current guidelines from the American Academy of Orthopaedic Surgeons (AAOS), a number of prophylactic modalities for the prevention of venous thromboembolism in total joint arthroplasty may be used. It is common practice that more potent prophylactic agents are used for patients at higher risk of venous thromboembolism. However, we are aware of no studies that have investigated the efficacy of potent anticoagulation in higher-risk individuals. Therefore, the purpose of our study was to test the hypothesis that low-molecular-weight heparin and warfarin result in a reduction in venous thromboembolism events in high-risk patients.

Methods:
A retrospective, multi-institutional study of 60,467 primary and revision total joint arthroplasties from 2000 to 2015 was performed. Identified medications were classified as aspirin, low-molecular-weight heparin, or warfarin. Patients with unavailable venous thromboembolism prophylaxis information or those not receiving the aforementioned prophylaxis were excluded. Information pertinent to the objective of this study was collected and a venous thromboembolism risk score was calculated based on 26 variables. Treatment outcomes assessed included 90-day rate of symptomatic venous thromboembolism and periprosthetic joint infection. Propensity score matching was performed (1:1), as well as logistic regression analysis on the total sample.

Results:
Aspirin prophylaxis demonstrated a lower rate of deep vein thrombosis, pulmonary embolism, and venous thromboembolism than warfarin and low-molecular-weight heparin alone throughout all risk scores. In the matched propensity score analysis, low-molecular-weight heparin and warfarin demonstrated increased odds of venous thromboembolism for both standard-risk and high-risk patients undergoing total knee arthroplasties compared with aspirin. For primary total hip arthroplasty, warfarin demonstrated an increased risk for high-risk patients and low-molecular-weight heparin demonstrated an increased risk for standard-risk patients. The prevalence of periprosthetic joint infection was higher in patients receiving warfarin (p < 0.001 for both comparisons of warfarin with aspirin and low-molecular-weight heparin).

Conclusions:
The results of this multi-institutional study demonstrate that the use of warfarin and low-molecular-weight heparin in higher-risk patients does not necessarily result in a reduction in symptomatic venous thromboembolism. Aspirin administered to higher-risk patients seems to be as effective as potent anticoagulation and more effective than warfarin.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Generalized Joint Laxity in Orthopaedic Patients
Authors: Sacks Hayley A. , Prabhakar Pooja , Wessel Lauren E. , Hettler Jessica , Strickland Sabrina M. , Potter Hollis G. , Fufa Duretti T. 
Published: April 2019

➤ Careful history and examination may reveal a constellation of musculoskeletal conditions associated with generalized joint laxity, including shoulder instability, posterolateral rotatory instability of the elbow, wrist ganglia, thumb base pathology, hip labral pathology, and patellar and ankle instability.➤ Subtle but highly suggestive findings associated with generalized joint laxity may be recognized on radiographs or magnetic resonance imaging that can impact the clinician’s decision-making.➤ Increasing evidence has suggested that clinical outcomes of various surgical procedures around the shoulder, hip, knee, and ankle may be impacted in patients with generalized joint laxity. Surgeons should counsel these patients accordingly to manage expectations.➤ Patients presenting to orthopaedic specialists should be queried about symptoms and injuries in other joints to identify patients with generalized joint laxity in order to initiate early management and injury prevention protocols.
Long-Term Outcomes of Constrained Liners Cemented into Retained, Well-Fixed Acetabular Components
Authors: Brown Timothy S. , Tibbo Meagan E. , Arsoy Diren , Lewallen David G. , Hanssen Arlen D. , Trousdale Robert T. , Abdel Matthew P. 
Published: April 2019

Background:Cementation of a constrained liner is a viable option for treating instability after total hip arthroplasty (THA) when the acetabular component is well fixed and well aligned. However, concerns regarding long-term mechanical failure and recurrent instability remain. The aim of this study was to evaluate the long-term survivorship, complications, and clinical and radiographic outcomes of constrained polyethylene liners cemented into well-fixed acetabular components at the time of revision THA.Methods:We identified 125 cases in which a constrained liner of 1 design was cemented into a retained, osseointegrated acetabular component during revision THA between 1998 and 2006. The mean patient age at revision was 70 years. Mean follow-up was 7 years. Survivorship data, risk of instability, and clinical and radiographic outcomes were analyzed.Results:Survivorship free from revision for instability was 86% at 5 years and 81% at 10 years. Survivorship free from aseptic acetabular component revision was 78% at 5 years and 65% at 10 years, with the most common failure mechanism being dissociation of the constrained liner from the acetabular component. Survivorship free from revision for any reason was 76% at 5 years and 60% at 10 years. The most common complications were instability and periprosthetic joint infection, with cumulative incidences at 7 years of 18% and 11%, respectively. Harris hip scores did not significantly improve. Cup position did not affect implant survivorship or risk of dislocation.Conclusions:Cementing a constrained liner into a retained acetabular shell at the time of revision THA has durable long-term results, with 8 in 10 patients free from instability at 10 years. Aseptic acetabular survivorship was worse (65%) at 10 years, primarily due to dissociation of the constrained liner from the acetabular component.Level of Evidence:TherapeuticLevel IV. See Instructions for Authors for a complete description of levels of evidence.
PELAKSANAAN LELANG TERHADAP OBYEK YANG DIBEBANI HAK TANGGUNGAN DALAM RANGKA MEWUJUDKAN KEADILAN PARA PIHAK
Authors: Nugroho Pandu Dwi 
Published: April 2019

Penelitian ini membahas tentang pelaksanaan lelang terhadap obyek lelang yang dibebani hak tanggungan dalam rangka mewujudkan keadilan para pihak. Pengaturan mengenai Hak Tanggungan diatur dalam Undang – Undang No.4 Tahun 1996 Tentang Undang – Undang Hak Tanggungan (UUHT). Permasalahan penelitian ini mengenai apakah obyek lelang dengan agunan yang telah dipasang Akta Pembebanan Hak Tanggungan dapat langsung dilelang melalui Kantor Pelayanan Kekayaan Negara dan Lelang serta bagaimana pelaksanaan lelang terhadap obyek hak tanggungan yang dapat mewujudkan keadilan para pihak. Untuk menjawab permasalahan tersebut diperlukan kegiatan penelitian hukum, menggunakan pendekatan yuridis normatif. Sumber data diperoleh melalui sumber kepustakaan yaitu peraturan perundang-undangan, teori hukum, dan pendapat para sarjana terkemuka sebagai sumber data utama, kemudian menganalisisnya agar mendapat jawaban secara ilmiah. Hasil Pembahasan dari penelitian ini : Pelaksanaan lelang dilakukan oleh Kantor Pelayanan Kekayaan Negara dan Lelang yang selanjutnya disebut dengan KPKNL diatur dalam Peraturan Menteri Keuangan No. 102 /PMK.01/2008 tentang Organisasi Dan Tata Kerja Instansi Vertikal Direktorat Jendral Kekayaan Negara Pasal 29 ayat (1), bahwa Kantor Pelayanan Kekayaan Negara dan Lelang (KPKNL) merupakan instansi vertikal Direktorat Jenderal Kekayaan Negara (DJKN) yang berada dibawah dan bertanggung jawab langsung kepada Kepala Kantor Wilayah yang dipimpin oleh seorang Kepala. Dalam Undang – Undang No.4 Tahun 1996 Pasal 10 ayat (1) menyatakan bahwa Pemberian hak tanggungan didahului dengan janji untuk memberikan hak tanggungan sebagai jaminan pelunasan hutang tertentu, yang merupakan bagian tak terpisahkan dari perjanjian utang piutang yang bersangkutan. Objek yang dibebankan atas hak tanggungan berada di bawah kekuasaan penerima hak tanggungan.Hal ini bertujuan untuk memberikan perlindungan dan kepastian hukum kepada kreditur apabila debitur cidera janji. Jika terjadi cidera janji, benda yang dijaminkan dengan hak tanggungan akan dijual untuk melunasi utang debitur yang dijamin tersebut.
Strategic Evaluation of Managed Pressure Drilling: An Application on Brazilian Dynamic-Positioning Rigs
Authors: Aranha Pedro Esteves , Colombo Danilo , Fernandes André Alonso , Vanni Guilherme Siqueira , Tomita Reinaldo Akio , Benevenuto de Campos Lima Cláudio , Lima Gilson Brito , César de Faria Alvim Wasserman Júlio 
Published: April 2019

Summary
The demand for ultradeepwater scenarios invoked the frequent application of managed pressure drilling (MPD) in the last few years. In an ultradeepwater scenario, oil companies face issues such as narrow pressure windows and severe loss zones. Many wells are considered undrillable without the aid of MPD technology. MPD operations need to be correctly evaluated with consideration given to increased time and cost/benefit analysis. In this paper, we propose a probabilistic model to evaluate MPD demand by estimating the optimal number of rigs equipped with MPD and a rotating control device (RCD), and we analyze which intervention strategy is the most cost– and time–effective. Reducing uncertainty is an important factor when making decisions about drilling. We adopted a Monte Carlo simulation using loss–zone estimation, probability of prediction error, the number of rigs equipped with MPD, and several strategies. Better MPD strategies were determined on the basis of available data and the optimal number of rigs equipped with an MPD system and RCD equipment, reducing subjectivity in the decision–making process. The originality of our paper lies in the new quantitative approach to dealing with uncertainty in the prediction of fluid losses and the cost and duration of different MPD strategies, numerically simulating the possible scenarios.
Monolayer Microproppant-Placement Quality Using Split-Core-Plug Permeability Measurements Under Stress
Authors: Kim Brice Y. , Akkutlu I. Yucel , Martysevich Vladimir , Dusterhoft Ronald G. 
Published: April 2019

Summary
The stress-dependent permeabilities of split shale core plugs from Eagle Ford, Bakken, and Barnett Formation samples are investigated in the presence of microproppants. An analytical permeability model is developed for the investigation, including the interactions between the fracture walls and monolayer microproppants under stress. The model is then used to analyze a series of pressure-pulse-decay measurements of the propped shale samples in the laboratory. The analysis provides the propped-fracture permeability of the samples and predicts a parameter related to the quality of the proppant areal distribution in the fracture. The proppant-placement quality can be used as a measure of success of the delivery of proppants into microfractures and to design stimulation experiments in the laboratory.
CO2 Stripping of Kerogen Condensates in Source Rocks
Authors: Baek Seunghwan , Yucel Akkutlu I.. 
Published: April 2019

SummarySignificant research has been conducted on hydrocarbon fluids in the organic materials of source rocks, such as kerogen and bitumen. However, these studies were limited in scope to simple fluids confined in nanopores, while ignoring the multicomponent effects. Recent studies using hydrocarbon mixtures revealed that compositional variation caused by selective adsorption and nanoconfinement significantly alters the phase equilibrium properties of fluids. One important consequence of this behavior is capillary condensation and the trapping of hydrocarbons in organic nanopores. Pressure depletion produces lighter components, which make up a small fraction of the in-situ fluid. Equilibrium molecular simulation of hydrocarbon mixtures was carried out to show the impact of CO2 injection on the hydrocarbon recovery from organic nanopores. CO2 molecules introduced into the nanopore led to an exchange of molecules and a shift in the phase equilibrium properties of the confined fluid. This exchange had a stripping effect and, in turn, enhanced the hydrocarbon recovery. The CO2 injection, however, was not as effective for heavy hydrocarbons as it was for light components in the mixture. The large molecules left behind after the CO2 injection made up the majority of the residual (trapped) hydrocarbon amount. High injection pressure led to a significant increase in recovery from the organic nanopores, but was not critical for the recovery of the bulk fluid in large pores. Diffusing CO2 into the nanopores and the consequential exchange of molecules were the primary drivers that promoted the recovery, whereas pressure depletion was not effective on the recovery. The results for N2 injection were also recorded for comparison.
Dynamics of Drilling Systems With an Antistall Tool: Effect on Rate of Penetration and Mechanical Specific Energy
Authors: Vromen Thijs , Detournay Emmanuel , Nijmeijer Henk , van de Wouw Nathan 
Published: April 2019

Summary
This paper considers the effect of an antistall tool on the dynamics of deep drilling systems. Field results show that the antistall tool increased the rate of penetration (ROP) of drilling systems when compared with ROP in offset wells drilled without this tool. We developed a model–based approach to investigate the effect of this downhole tool on the ROP and on the mechanical specific energy. Toward this, a drillstring model including the antistall tool was constructed; it describes the coupled axial/torsional dynamics in the form of delay differential equations. Simulation results and a dynamic analysis based on averaging the obtained steady–state response show that an increased drilling efficiency was obtained using the antistall tool, resulting in a higher ROP.
Demographic profile, clinical features, and outcome of peripapillary subretinal hemorrhage: an observational study
Authors: Zou Ming , Zhang Yi , Huang Xi , Gao Sheng , Zhang Junjun 
Published: April 2019

Abstract
Background

To evaluate the etiology, demographic profile, clinical features, and outcomes in patients with peripapillary subretinal hemorrhage (PSH).

Methods

Thirty-eight eyes of 37 consecutive patients with PSH were enrolled in this prospective observational study over 4 years; all were followed for 2 years. The main outcome measures were demographic profile, possible etiology, clinical features, outcome, and prognosis.

Results

Sixty-eight percent (26/38) of eyes were in female patients; the mean patient age was 20 years. Only 1 patient (1/37) showed bilateral involvement. All patients experienced acute onset of PSH. All eyes were myopic and their best-corrected visual acuities ranged from 20/1000 to 20/12.5. The fundus features of affected eyes were classified into 3 groups: (1) PSH alone (4/38 eyes, 10.5%); (2) PSH with intrapapillary hemorrhage (17/38 eyes, 44.7%); (3) PSH with intrapapillary and vitreous hemorrhage (17/38 eyes, 44.7%). PSH occurred in nasal edges of optic discs with a crescent shape and dull-red color. All affected optic discs were small and crowded, exhibiting variable degrees of tilting. The cup of affected optic discs was narrower and deeper than that of normal control discs. Other ancillary tests provided no additional value. After a mean follow-up of 2.85 months, the hemorrhages resolved spontaneously without sequelae. Recurrence of disease was not observed in any patients.

Conclusions

PSH is common in myopic eyes with tilted optic discs. We suspect that these hemorrhages occurred as a result of abrupt movement acting on a morphologically vulnerable optic disc.
Neurosyphilis presenting with myelitis-Case series and literature review
Authors: Wu Yali , Wu Wenqing 
Published: April 2019

Abstract
Background
Neurosyphilis is a great imitator because of its various clinical symptoms. Syphilitic myelitis is extremely rare manifestation of neurosyphilis and often misdiagnosed. However, a small amount of literature in the past described its clinical manifestations and imaging features, and there was no relevant data on the prognosis, especially the long-term prognosis. In this paper, 4 syphilis myelitis patients admitted to our hospital between July 2012 and July 2017 were retrospectively reviewed. In the 4 patients, 2 were females, and 2 were males. We present our experiences with syphilitic myelitis, discuss the characteristics, treatment and prognosis.
Case presentation
The diagnosis criteria were applied: (1) diagnosis of myelitis established by two experienced neurologist based on symptoms and longitudinally extensive transverse myelitis (LETM) at the cervical and thoracic levels mimicked neuromyelitis optic (NMO) on magnetic resonance imaging (MRI) ; (2) Neurosyphilis (NS) was diagnosed by positive treponema pallidum particle assay (TPPA) and toluidine red untreated serum test (TRUST) in the serum and CSF; (3) negative human immunodeficiency virus (HIV). Likewise, all patients were negative for serum anti-aquaporin 4 (AQP-4), as well as negative bacterial, fungal, virus, or mycobacterium tuberculosis in the CSF. Treatment included intravenous penicillin G, with 24 million units of penicillin G per day administered intravenously for 14 days, and three patients were also treated with systemic corticosteroids. Neurological examination, serologic syphilis diagnostic tests (TPPA, TRUST) and cerebrospinal fluid tests (TPPA, TRUST) were examined approximately every 12~24 weeks after treatment. The follow-up time ranged from 12 to 70 months, with an average of 36.6 months. The prognosis was well in 3 cases who received early anti-syphilis treatment, but 1 case who received delayed treatment due to misdiagnose had no improvement.
Conclusions
Neurosyphilis should be considered when there are long hyperintensity lesions in the MRI spinal cord. Prompt diagnosis and combined antibiotics-corticosteroid therapy may improve neurological prognosis.
PREREQUISITES FOR THE FORMATION OF D - ENANTIOMERS OF AMINO ACIDS OF ANIMAL PROTEINS IN THE MANUFACTURING PROCESS OF MEAT PRODUCTS
Authors: Vostrikova Natal’ya L. , Kuznetsova Oksana A. , Krylova Valentina B. , Kulikovskii Andrey V. 
Published: April 2019

The paper presents studies on the presence or formation of d - enantiomers of amino acids in animal tissues or organs, in meat products during its production processes. It is shown that the process of epimerization of L - amino acid residues with the formation of D-enantiomers affect the reduction of the properties of food products, including the formation of oncoassociated subsequent effects on the human body.Modern control of the quantitative and qualitative composition of d-enantiomers of amino acids in food products, monitoring for stratification of the increased risk of toxic compounds in food are becoming an urgent medical and social problem. The studies planned in this paper are aimed at developing approaches to the creation of food products that reduce the oncogenic alimentary load on human health by solving the problem of technological modification of production, eliminating or minimizing post - translational modifications in proteins that contribute to the formation of d-enantiomers of amino acids. These studies will create a scientific and technological database associated with the risk assessment of carcinogenesis in protein matrices of animal origin. Based on the presented analysis, the task of developing and testing a method to control the accumulation of D-isomers in the course of various technological processes of meat production is extremely popular.
THE INFLUENCE OF IONIZING RADIATION ON THE THERMOPHYSICAL PROPERTIES OF MEAT FROM THE BROILER CHICKENS WITH DIFFERENT STRESS RESISTANCE
Authors: Timakova Roza T. , Tikhonov Sergey L. , Tikhonova Natal’ya V. , Shikhalev Sergey V. , Kudryashov Leonid S. 
Published: April 2019

The studies on the influence of radiation treatment of carcasses from the stress-resistant and stress-sensitive broiler chickens on the thermophysical properties of raw meat are presented. An increase in thermal diffusivity of meat from the stress-resistant poultry by 24.7 % and 54.7 % after radiation treatment of carcasses with ionizing radiation doses of 9 kGy and 12 kGy, respectively, was established. In meat from the stress-sensitive poultry, this figure increased by 33.3 % and 35.8 % compared to the untreated carcasses.It is shown that radiation treatment of carcasses by applied doses increased the thermal conductivity coefficient of meat from the stressresistant poultry by 5.3% and 7.0 %; in meat from the stress-sensitive poultry, this figure increased by 2.0 and 6.2 times compared to meat from the carcasses not exposed to radiation. At the same time, the value of the heat capacity coefficient was reduced. The irradiated poultry meat samples accumulate energy of ionizing radiation more intensively, which allows the intensification of the thermal processes occurring at various stages of meat product production. Treatment of meat from the stress-resistant poultry with ionizing radiation can reduce the amount of meat with non-traditional autolysis due to changes in its functionaltechnological properties. The results of the research should be taken into account in technological processes in the production of meat products with non-traditional autolysis.
Therapy of bacterial vaginosis
Authors: Marushkina O. I. 
Published: April 2019

Aim:evaluation of efficacy of Multi-Gyn® Actigel application in the complex therapy of bacterial vaginosis (BV) and prevention of its recurrence in pregnant women.Patients and methods:87 patients of reproductive age were examined and treated with the diagnosis of «bacterial vaginosis, chronic recurrent course». 41 of them from the main group were given Multi-Gyn® Actigel at the 1st stage of treatment, while 46 women of the comparison group were given 2% clindamycin cream In order to restore vaginal microbiocenosis, a probiotic containing Lactobacillus casei rhamnosus spp. LCR35 was used in both groups at the second stage Clinical laboratory methods were used.Results:efficacy of Multi-Gyn® Actigel application in complex therapy of BV and prevention of its recurrences in non-pregnant women was proved. As a result of Multi-Gyn® Actigel prescription there were no complaints, pH level was normalized, almost complete absence of BV-associated microorganisms was achieved and lactobacillus pool preservation even in the distant period after treatment.Conclusion:Multi-Gyn® Actigel is an effective remedy for treatment of BV and prevention of its recurrence in non-pregnant patients, especially in the chronic recurrent course of the disease. This effect is achieved not only by eliminating anaerobic microorganisms, but also due to the persistent preservation of the lactobacillus pool.