bluuebunny/crossref_metadata_2025_split huggingface dataset:
Roteiro de como criar um periódico científico
Authors: Santos Gildenir Carolino 
Published: November 2024

Introdução: O guia "Roteiro de Como Criar um Periódico Científico", é um recurso detalhado que visa orientar pesquisadores e instituições na criação e gestão de periódicos científicos. Publicado pelo Portal de Periódicos da UNICAMP em 2024, o documento abrange desde os conceitos básicos até as práticas avançadas de editoração e publicação científica. Objetivo: O principal objetivo do guia é fornecer um passo a passo abrangente para a criação de um periódico científico, abordando aspectos essenciais como planejamento, registro, questões éticas, uso de identificadores digitais (ISSN, DOI, ORCID), gerenciamento editorial, e políticas de preservação digital. O guia também destaca a importância da integridade acadêmica, da adoção de normas padrão (ABNT, APA, Vancouver), e da visibilidade dos periódicos através de indexadores e plataformas como Google Scholar. Considerações Finais: O guia enfatiza a necessidade de um planejamento cuidadoso e de uma gestão eficiente para garantir a qualidade e a sustentabilidade dos periódicos científicos. A adoção de práticas éticas, o uso de tecnologias de detecção de plágio, e a participação em redes de preservação digital são fundamentais para manter a integridade e a credibilidade das publicações. Além disso, o guia incentiva a transparência e a colaboração na comunicação científica, alinhando-se com os princípios da Ciência Aberta.
ДРАГУНСЬКІ ФОРМУВАННЯ В ЗБРОЙНИХ СИЛАХ ГЕТЬМАНЩИНИ СЕРЕДИНИ — ДРУГОЇ ПОЛОВИНИ XVII СТ.
Authors: Сокирко О. 
Published: November 2024

Статтю присвячено появі, становленню та розвитку драгунських формувань в армії Гетьманщини. З’ясовано витоки та історичний контекст появи кінної піхоти, її організацію, тактику й участь у війнах. Формування драгунських підрозділів розпочалося в ході спроб гетьманів створити постійну армію в добу Козацької революції середини XVII ст. Організація, озброєння й тактика драгунів орієнтувалися на західноєвропейські взірці, з якими козацькі старшини були знайомі з часів Речі Посполитої, в армії котрої аналогічні формування виникли раніше. Через складність фінансування й підготовки цих відділів вони не дуже поширилися, залишившися в складі прибічної гетьманської гвардії.
Molecular engineering and dynamic activation mechanism of a PAM-flexible compact CRISPR-Cas9
Authors: Nureki Osamu , Nakagawa Ryoya , Omura Satoshi , Kajimoto Shohei , Okazaki Sanae , Hirano Hisato , Yamashita Keitaro , Nishimasu Hiroshi , Ishiguro Soh , Mori Hideto , Yuji Kashiwakura , Hiramoto Takafumi , Takana Mamoru , Jividen Kasey , Tsai Shengdar , Yachie Nozomu , Ohmori Tsukasa 
Published: November 2024

Abstract

Staphylococcus aureus Cas9 (SaCas9), which is smaller than the widely-used Streptococcus pyogenes Cas9 (SpCas9), has been harnessed for gene therapy using an adeno-associated virus vector. However, SaCas9 requires an NNGRRT (where N is any nucleotide and R is A or G) protospacer adjacent motif (PAM) for target DNA recognition, thereby restricting the targeting range. In addition, the nuclease activation mechanism of SaCas9 remains elusive. Here, we rationally engineered a SaCas9 variant (eSaCas9-NNG) with an expanded target scope and reduced off-target activity. eSaCas9-NNG induced indels and base conversions at endogenous sites bearing NNG PAMs in human cells and mice. We further determined the cryo-electron microscopy structures of eSaCas9-NNG in four sequential states, PAM-checking state, DNA-unwinding state, pre-catalytic state and catalytically active state, which illuminate notable differences in the activation mechanisms between small SaCas9 and larger SpCas9. Overall, our findings demonstrate that eSaCas9-NNG could be used as a versatile genome editing tool for in vivo gene therapy, and improve our mechanistic understanding of the diverse CRISPR-Cas9 nucleases.
Maximizing biochar climate change mitigation impact through optimized logistic
Authors: Lefebvre David , Heitz Matthieu , Edgar Jack , Bi Xiaotao , Meersmans Jeroen , Cornelis Jean-Thomas 
Published: November 2024

Abstract

Carbon dioxide removal (CDR) practices are essential for mitigating the adverse impacts of climate change. Some CDR practices depend on the availability and accessibility of feedstocks. The climate change mitigation potential of these practices relies on the difference between their location-specific efficiency and the greenhouse gas (GHG) emissions associated with establishing them. Focusing on biochar from forestry harvest residues in British Columbia (Canada), this manuscript demonstrates that optimizing the selection of biochar application areas and transportation routes can double the climate change mitigation potential of the practice across the province compared to random selection. We argue that spatially explicit ex-ante modeling of CDR potential and transportation optimization should become the norm for any new relevant CDR project to ensure the maximization of their climate change mitigation potential.
Using Generative AI to Extract Structured Information from Free Text Pathology Reports
Authors: Shahid Fahad , Hsu Min-Huei , Chang Yung-Chun , Jian Wen-Shan 
Published: November 2024

Abstract

Manually converting unstructured text pathology reports into structured pathology reports is very time-consuming and prone to errors. This study demonstrates the transformative potential of generative AI in automating the analysis of free-text pathology reports. Employing the ChatGPT Large Language Model within a Streamlit web application, we automated the extraction and structuring of information from 33 unstructured breast cancer pathology reports from Taipei Medical University Hospital. Achieving a 99.61% accuracy rate, the AI system notably reduced the processing time compared to traditional manual methods. This not only underscores the efficacy of AI in converting unstructured medical text into structured data but also highlights its potential to enhance the efficiency and reliability of medical text analysis. Through this technological integration, we aimed to substantiate the capabilities of generative AI in improving both the speed and reliability of data processing, thereby fostering enhanced research and more accurate diagnostic practices. The outcomes of this study affirm that generative AI can significantly transform the handling of pathology reports, promising substantial advancements in clinical diagnostics and medical research by facilitating the structured analysis of complex medical data.
Design and Evaluation Patient Portal for Patients with HTLV-1
Authors: Aval Reyhane Nourozi , Rafatpanah Houshang , Sarbaz Masoumeh , Kimiafar Khalil , baigi Seyedeh Fatemeh Mousavi 
Published: November 2024

Abstract

Background: Patient portals are increasingly accepted as part of standard medical care. This study aimed to design and evaluate a patient portal for patients with Human T-lymphotropic virus 1 (HTLV-1) that provides information to learn more about their medical conditions.
Methods: This Cross-sectional descriptive study was carried out in four phases. 1) Literature review in scientific database and analysis of users ‘needs. 2) Use Delphi techniques by a multidisciplinary workgroup of Neurologists, Immunologists, and Specialists in Health Information Management and Medical Informatics, 3) Desing a patient portal, 4) User evaluation by patients and professionals is done by the SUS scale and Nielsen's principles questionnaire.
Results: We developed a portal that includes Six structural features including: home page, patient profile, care team, educational materials, contact us, and about us. The most important features of the portal in the survey conducted on patients included: Reminders for appointments (93.3%), making an appointment (90%), requesting medication recipes (83.3%), viewing test results (70%), and others. Also, the SUS results showed that the users found the portal user-friendly, useful, and efficient.
Conclusion: It can also be said that patients have different needs, so designing a portal to provide information and support to these people seems essential.
Vitamin D deficiency is a more frequent finding in hirsutism or not?
Authors: Eftekhari Hojat , Darjani Abbas , Alizadeh Narges , Nejad Kaveh Gharaei , Rafiei Rana , Ghorbani Mahsa , Rafiei Elahe 
Published: November 2024

Abstract

Introduction
Evidence shows that vitamin D (Vit D) insufficiency is associated with some hormonal disorders. Hirsutism is a prevalent hormonal condition, which is associated with androgenic hormones. Disturbance of Vit D level affects regulation of these hormones and may result in hirsutism. This study compared the Vit D levels of women with and without hirsutism.
Methods
In this cross-sectional study, 202 women were included (101 with hirsutism and 101 without). 25-hydroxy Vit D level was assessed using high-performance liquid chromatography (HPLC). All data was analyzed based on a significance level < 0.05.
Results
The distribution of different ages was similar in both groups with and without hirsutism (P > 0.05). The mean level of Vit D had no statistically significant differences in the hirsutism group (21.40 ng/ml) compared to non-hirsutism group (21.20 ng/ml) (P > 0.05). Also, no significant differences between menstrual pattern, body mass index and existence of polycystic ovary, with different levels of Vit D were observed (P > 0.05).
Conclusion
The study found no significant difference in Vit D levels between individuals with and without hirsutism. About half of the individuals in both groups had Vit D deficiency.
Evolution algorithm with adaptive genetic operator and dynamic scoring mechanism for large-scale sparse many-objective optimization
Authors: zhao wei , Wang Xia , Tang Jianing , Dai Zhongbin , Feng Yaning 
Published: November 2024

Abstract

Large-scale sparse multi-objective optimization problems are prevalent in numerous real-world scenarios, such as neural network training, sparse regression, pattern mining and critical node detection, where Pareto optimal solutions exhibit sparse characteristics. The extensive number of decision variables and sparsity requirements make the optimization algorithms face more challenges. To address these issues more effectively, this paper proposes an evolution algorithm with the adaptive genetic operator and dynamic scoring mechanism for large-scale sparse many-objective optimization (SparseEA-AGDS). Within the evolutionary algorithm for large-scale Sparse (SparseEA) framework, the proposed adaptive genetic operator and dynamic scoring mechanism adaptively adjust the probability of cross-mutation operations based on the fluctuating non-dominated layer levels of individuals, concurrently updating the scores of decision variables to encourage superior individuals to gain additional genetic opportunities. Moreover, to augment the algorithm's capability to handle many-objective problems, a reference point-based environmental selection strategy is incorporated. Comparative experimental results demonstrate that the SparseEA-AGDS algorithm outperforms five other algorithms in terms of convergence and diversity on the SMOP benchmark problem set with many-objective and also yields superior sparse Pareto optimal solutions.
Microbiologically influenced corrosion in uncoated and coated mild steel
Authors: Ali Sheikh Idrees , nazir sheikh 
Published: November 2024

Abstract

The study aimed to investigate the corrosion performance of Zn-Ni-Cu and Zn-Ni-Cu-TiB2 coatings in the microbial-induced environment (E-Coli, ATCC 25922, and 3.5%NaCl solution). Zn-Ni-Cu and Zn-Ni-Cu-TiB2 were surfaces coated on an ASTM A-36 Steel substrate utilizing a high-velocity oxy-fuel (HVOF) thermal spray process. Immersion tests following ASTM G-31, and ASTM G1-03, standards were performed in Escherichia Coli (E-Coli, American Type Culture CollectionATCC25922) bacteria medium.The effect of Zn, Ni, and Ti was studied in preventing microbial-induced corrosion.SEM, and XRD analysis before and after helped to understand the morphological and structural changes in coated/uncoated ASTM A-36 steel. Various forms of rust were ascertained in XRD analysis. The inclusion of Zn and Cu inhibited bacterial attachment to the coated surface, hence preventing significant corrosion of the underlying substrate.The coatings performed effectively and inhibited bacterial growth. The uncoated ASTM A-36 Steel specimen showed well-developed bacterial colonies on the surface and in the solution medium. All forms of rust were reported in XRD analysis for uncoated ASTM A-36 steel while few forms of rust were reported in coated ASTM A-36 steel. Electrochemical impedance spectroscopy (EIS) and Tafel polarization in Escherichia coli (E-Coli, ATCC 25922) medium demonstrated that the coated samples had greater corrosion resistance than the uncoated ASTM A-36 Steel specimens. The higher corrosion potential (Ecorr) values of the two coated samples indicated improvedanodicprotection.
Coastal flood impacts and lost ecosystem services along Europe’s Outermost Regions and Overseas Countries and Territories
Authors: Vousdoukas Michalis I. , Patrotny Dominik , Mentaschi Lorenzo , Monioudi Isavela N , Feyen Luc 
Published: November 2024

Abstract

Climate change is expected to result in rising seas, exacerbating coastal floods1 and erosion2. Remote islands are projected to be among the most challenged regions, due to their geographic isolation and fragile economies. While, Small Island Developing States have been attracting the attention of scientists and policy makers, Europe’s Outermost Regions (ORs) and Overseas Countries and Territories (OCTs) remain poorly studied in terms of their impacts from Sea Level Rise (SLR). Here we carry out a data-modelling framework to comprehensively study risks of flooding, the submergence of flat regions, and coastal erosion along coastlines of ORs and OCTs. Our study shows that under a high emissions scenario by 2150 annually nearly 3,000 km2 is expected to be flooded, one third of which by tidal flooding, while 150 km2 of land will be lost by coastal erosion. This translates into an annual exposure to coastal inundation of up to half a million of people and an economic damage of 5.9 € billion per year - a 40-fold increase from today. Our study shows the increasing benefits in time of stringent climate mitigation, which could nearly halve these impacts in the long run. However, sea levels will continue to rise long after net zero carbon is reached, and so will the consequent impacts, highlighting the critical importance of proactive efforts to increase the resilience of these vulnerable regions against rising seas.
Betulinic Acid and Oleanolic Acid Modulate CD81 Expression and Induce Apoptosis in Triple-Negative Breast Cancer Cells through ROS Generation
Authors: Lestari Dian Yuliartha , Mastutik Gondo , Mukono Indri Safitri 
Published: November 2024

Abstract

Background
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by a lack of hormones and the HER2 receptor, making it unresponsive to targeted therapy. Triterpenoids such as betulinic acid (BA) and oleanolic acid (OA) have anticancer effects by inducing apoptosis in TNBC cells. CD81 is a tetraspanin that affects the growth and metastasis of cancer cells.
Aim
To evaluate the effect of BA and OA on viability MDA-MB 231 by analyzed of CD81 expression, intracellular ROS and apoptosis.
Materials and Methods
The TNBC cell, MDA-MB 231, was cultured and exposed by BA dan OA. The viability cell was evaluated by the CCK-8 assay. The binding of BA dan OA to CD81 was analyzed using molecular docking. This study evaluated CD81 expression, intracellular ROS, and apoptosis by flow cytometri.
Results
The result showed that BA and OA inhibited viability of MDA-MB-231 cells. BA and OA bind to CD81 in silico, with binding affinities of 9.0 kcal/mol for BA and 7.2 kcal/mol for OA. Flow cytometry results revealed that BA can downregulate CD81 expression. BA and OA also increased intracellular ROS levels and induced apoptosis.
Conclusion
These findings suggest that BA and OA, especially BA, can modulate CD81 expression and promote apoptosis in TNBC cells through the generation of ROS, thereby offering a potential therapeutic strategy for the treatment of TNBC.
Time-domain stereoscopic imaging
Authors: Yan Ming , Wang Zijian , Ma Hui , Luo Jinwei , Huang Kun , Fang Jianan , Ge Jingman , Zeng Heping 
Published: November 2024

Abstract

Stereoscopy harnesses two spatially offset cameras to mimic human vision for depth perception, enabling three-dimensional (3D) optical imaging for various remote sensing applications. However, its depth precision and accuracy are limited by insufficient spatial resolving power. Achieving high precision alongside extensive measurable ranges and high-speed measuring capabilities has long been a challenge in 3D imaging. To address this, we introduce time-domain stereoscopy, a concept inspired by space-time duality in optics. Specifically, it employs two temporally offset optical gating cameras to capture time-domain parallax signals, enabling rapid and precise time-of-flight measurements for depth retrieval. Leveraging two advanced technologies—femtosecond electro-optical comb synthesis and nonlinear optical sampling—this method achieves sub-100 nm depth precision across multimeter-scale imaging ranges and supports millisecond-scale displacement and velocity measurements for 47 million spatial points simultaneously. As such, it provides a versatile tool for applications in surface metrology, mechanical dynamics, and precision manufacturing.
Evaluating Comprehensive Land Use Efficiency in Homestead Consolidation under the 'Three Rights Separation' Framework: Insights from Feicheng City, China
Authors: Gong Maogang , Gao Xinyu 
Published: November 2024

Abstract

The separation of ownership, qualification, and use rights of homestead provides an institutional guarantee for the consolidation of homestead, thereby promoting its intensive and efficient utilization. This study uses Feicheng in Shandong as a case study, employing the synthetic control method to construct an indicator system for comprehensive land utilization to assess land use efficiency following the implementation of the village consolidation policy. By calculating the discrepancy between actual and synthetic values, the impact of village consolidation is visually discerned. Starting in 2009, the impact became increasingly pronounced, with a yearly upward trend. From 2017 to 2020, a slight decline in the effect was observed due to a weakening of the policy's sustained effectiveness, but it still maintained a positive trend. Robustness tests, including placebo tests and the ratio of mean squared errors, further confirm that the implementation of the village consolidation in Feicheng has a significant positive effect on comprehensive land use efficiency. Based on the research conclusions, it is recommended to enhance the efficiency of land use in village consolidation by improving institutional policies, public infrastructure, village planning, the quality of life for farmers, and ecological environment protection.
Reaction-induced regioselective reconstruction of Ni-doped Ce(OH)3/CeO2 enables exceptional activity and selectivity for reverse water-shift reaction
Authors: Qu Yongquan , Li Wenbin , Liu Bing , Guo Qing , Guo Wenjie , Zhang Sai 
Published: November 2024

Abstract

Reconstruction of catalysts by reaction environments represents a viable approach to create highly performed active sites. Herein, we developed a reaction-induced regioselective reconstruction of Ni-doped Ce(OH)3/CeO2 nanorods to form dual-active sites composed of carburized Ni clusters and frustrated Lewis pairs (FLPs), delivering exceptional activity, selectivity and stability for reverse water-gas shift reaction. Ni aggregation in the Ce(OH)3 region, coupled with in-situ carbonization of Ni by catalytically generated CO during reaction, induced the formation of the carburized Ni clusters, which effectively promoted H2 dissociation. Additionally, Ni doping in the CeO2 region and Ce(OH)3-to-CeO2 phase transition introduced more oxygen vacancies and thereby generated FLPs in CeO2, which facilitated CO2 adsorption and subsequent hydrogenation by spilled H* species from the carburized Ni clusters. Weak CO adsorption on both the carburized Ni clusters and FLPs significantly suppressed the methanation side-reaction. This reaction-induced regioselective reconstruction strategy provides a new avenue for designing highly performed catalysts.
Exergaming-based Esports Intervention for Older Adults in Hong Kong: A Non-Randomized Controlled Trail Study
Authors: Man Leung Ka , YUCHEN SHI 
Published: November 2024

Abstract

Exergaming, refers to the video gaming with/without virtual reality which required the use of physical activity during gameplay, has been utilized as an emerging type of physical activity in improving older adults’ physical and mental health. Exergaming can also be considered as esports when the competitive and interactive element is embedded in the gameplay. To date, the impact of exergaming-based esports on older adults’ health and well-being conditions has been less investigated. This study aims to examine the effectiveness of exergaming-based esports intervention program in promoting older adults’ physical, psychological, and cognitive health outcomes in Hong Kong. A total of 54 older adults were recruited and 48 (male = 12; female = 36) were finally retained for data analysis due to six of them did not attend the post-test. All participants were allocated into either an esports group (EG = 24) and a control group (CG = 24). EG participants were invited to participate in an eight-week exergaming-based esports intervention program consisting of 16 training sessions to learn and play the Nintendo Switch™ Fitness Boxing game. A fitness boxing competition was embedded in the final three sessions. Besides, CG participants were instructed with their normal daily activity. Measures including Senior Fitness Test, the University of California, Los Angeles (UCLA) Loneliness Scale (ULS-8), the Chinese version of the Physical Activity Enjoyment Scale (PACES), the number comparison test and trail making test (TMT), and the Short Form-36 (SF-36) Health Survey were used to examine older adults’ physical, psychological, and cognitive conditions. Analysis of covariance (ANCOVA) was used for data analysis. The results showed that EG participants had better lower body strength, better agility, higher aerobic endurance, higher enjoyment level and higher cognitive functioning. This study provides theoretical contribution by filling in the research gap of the investigation of the beneficial effects of exergaming-based esports in enhancing older adults’ health conditions in Hong Kong. Besides, game designers are encouraged to design specific game types with competitive and interactive elements embedded for older adults to play and thus promote their emotional and cognitive well-being.