bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are we there yet? CAR‐T therapy in multiple myeloma
Authors: Mirvis Eitan , Benjamin Reuben 
Published: November 2024

SummaryThe last few years have seen a revolution in cellular immunotherapies for multiple myeloma (MM) with novel antigen targets. The principle new target is B‐cell maturation antigen (BCMA). Autologous chimeric antigen receptor T‐cell (CAR‐T) therapy directed against BCMA was first approved by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) in 2021, although approval by the National Institute for Health and Care Excellent (NICE) is awaited. Initial response rates in patients with heavily pretreated MM have been impressive, but patients are still relapsing. Furthermore, CAR‐T manufacturing is expensive and time‐consuming, and T‐cell fitness is impaired by prior MM treatment. Numerous strategies to improve outcomes and delivery of cellular immunotherapy are under investigation, including next‐generation CARs, allogeneic ‘off‐the‐shelf’ CARs and targeting of other MM antigens including G protein‐coupled receptor, class C, group 5, member D (GPRC5D), Fc receptor homologue 5 (FcRH5), cluster of differentiation (CD)19, signalling lymphocyte activation molecule family member 7 (SLAMF7) and several others. In this exciting and rapidly evolving treatment landscape, this review evaluates the most recent clinical and preclinical data pertaining to these new cellular immunotherapies and explores strategies to overcome resistance pathways. On the protracted journey to a long‐term cure, we outline the challenges that lie ahead and ask, ‘Are we there yet?’
Museum Educators Perspective of Failure: A Collective Frame Analysis
Authors: Simpson Amber , Osterhout Andrew , Anderson Alice , Maltese Adam V. 
Published: November 2024

ABSTRACTMuseums offer a unique role and safe space in shaping how youth view and react to experiences with failure. The purpose of this study was to add to the conversation around failure in out‐of‐school learning, particularly from the perspective of educators within museum settings that implement STEAM‐related making exhibits, workshops, and/or camps for youth. We analyzed approximately 9 h of video data from two sources: video recordings of virtual group meetings with 14 museum educators from six partnering institutions, and video recordings from five of the individual partnering sites discussing failure as a concept within their organization and programming. In this article, we demonstrate how the framings of failure by museum educators are bounded, and transformed, by un/seen external forces that ultimately impact the professional practices of educators in their organizations. We contend that the significance of this study lies in how perspectives around failure are produced and how they influence educators' professional practice, specifically in how failure is framed and communicated within STEAM‐related learning opportunities in museum settings.
Deepening Root Inputs: Potential Soil Carbon Accrual From Breeding for Deeper Rooted Maize
Authors: Cotrufo M. Francesca , Haddix Michelle L. , Mullen Jack L. , Zhang Yao , McKay John K. 
Published: November 2024

ABSTRACTBreeding annual crops for enhanced root depth and biomass is considered a promising intervention to accrue soil organic carbon (SOC) in croplands, with benefits for climate change mitigation and soil health. In annual crops, genetic technology (seed) is replaced every year as part of a farmer's fixed costs, making breeding solutions to climate change more scalable and affordable than management approaches. However, mechanistic understanding and quantitative estimates of SOC accrual potentials from crops with enhanced root phenotypes are lacking. Maize is the highest acreage and yielding crop in the US, characterized by relatively low root biomass confined to the topsoil, making it a suitable candidate for improvement that could be rapidly scaled. We ran a 2‐year field experiment to quantify the formation and composition (i.e., particulate (POM), coarse and fine mineral–associated organic matter (chaOM and MAOM, respectively) of new SOC to a depth of 90 cm from the decomposition of isotopically labeled maize roots and exudates. Additionally, we used the process‐based MEMS 2 model to simulate the SOC accrual potential of maize root ideotypes enhanced to either shift root production to deeper depths or increase root biomass allocation, assuming no change in overall productivity. In our field experiment, maize root decomposition preferentially formed POM, with doubled efficiency below 50 cm, while root exudates preferentially formed MAOM. Modeling showed that shifting root inputs to deeper layer or increasing allocation to roots resulted in a deterministic increase in SOC, ranging from 0.05 to 0.15 Mg C ha−1 per year, which are at the low end of the range of published SOC per hectare annual accrual estimates from adoption of a variety of crop management practices. Our analysis indicates that for maize, breeding for increasing root inputs as a strategy for SOC accrual has limited impact on a per‐hectare basis, although given that globally maize is produced on hundreds of millions of hectares each year, there is potential for this technology and its effect to scale. For maize–soy system that dominates US acres, changes in the overall cropping system are needed for sizable greenhouse gas reductions and SOC accrual. This study demonstrated a modeling and experimental framework to quantify and forecast SOC changes created by changing crop root inputs.
The Choices We Collectively Make: Orchestrating Hybridity to Tackle Grand Challenges
Authors: Grabski‐Walls Tiffany , Ambos Tina C. 
Published: November 2024

AbstractHybrid organizing offers new ways to address grand challenges by balancing profit and sustainability. However, current research on hybridity focuses mainly on individual organizations, while grand challenges involve complex networks of interconnected yet independent actors. This paper introduces a new perspective on hybridity showing how single organizations engage others to enable collective solutions. Through the lens of orchestration, we uncover the role of three Latin American stock exchanges in driving collective hybridity in a qualitative process study. Our multi‐level model reveals the sequential activities of an orchestrator – catalysing, brokering, and building – and a process of collective tension management. We extend theory on how organizations can engage an entire ecosystem to adopt hybridity and how hybrid organizing can drive large‐scale solutions to grand challenges.
Registered Nurses' Knowledge and Attitudes Towards Psychedelics in Healthcare: Statewide Survey Results
Authors: Graefe Anna C. , Weirick Madison E. , Harpin Scott B. , Dorsen Caroline , Porta Carolyn M. 
Published: November 2024

ABSTRACTIntroductionPsychedelic science is re‐emerging to address mental health conditions, of which certain populations in the United States experience disparities. However, the perspectives of registered nurses (RNs), who have important roles within mental health care, towards psychedelics are largely unknown.Aim/QuestionTo assess attitudes, knowledge, and beliefs of a large, state‐wide sample of RNs towards psychedelics in healthcare settings.MethodRNs were randomly selected from a statewide directory to participate in a cross‐sectional, multi‐method online survey.Results793 RNs completed all items, with generally positive attitudes towards psychedelics but mixed opinions regarding the legal landscape, including decriminalisation. Few (12.7%) reported psychedelic content in their training, and most expressed low confidence in their knowledge.DiscussionFindings generally align with previous research regarding provider attitudes towards psychedelics. Participants in this study had slightly more favourable attitudes and higher knowledge scores.LimitationsThe study has potential selection bias, lacks a priori power analysis, and is limited to one state.ImplicationsAs psychedelic science emerges as a potential treatment option for several mental health conditions, RNs must be prepared to support individuals and communities.RecommendationsAdditional education in this emerging area of mental health nursing is warranted to ensure RN competence and confidence.
Carbon footprint assessment and reduction strategies for aquaculture: A review
Authors: Li Haocheng , Zhou Xiaoqing , Gao Li , Liang Jian , Liu Huiru , Li Yongren , Chen Limei , Guo Yongjun , Liang Shuang 
Published: November 2024

AbstractAquaculture generates less greenhouse gas emissions compared to other agriculture practices due to its limited land‐use changes, improved feed conversion rates, and reduced methane emissions from animals' digestive systems. The aquaculture carbon emissions come from various production stages, including feed production, farm operations, processing, transportation, and so forth. This review illustrates the theories, calculation methods, and practical applications of the carbon footprint in fisheries and aquaculture, as well as the challenges and strategies for emission reduction. The factors influencing the carbon footprint of fishing and manufacturing aquaculture are also discussed. Further research should focus on refining carbon footprint assessment techniques, promoting green technologies and sustainable aquaculture practices. Managing aquaculture's carbon footprint though is crucial for mitigating environmental impacts and supporting sustainable development.
Translating Booker T. Washington in China: Blackness, racial discourse and Chinese nationalism, 1903–1949
Authors: Feng Jia 
Published: November 2024

AbstractThis article examines the racialised discourse on Booker T. Washington (1856–1915, African‐American educational pioneer) appropriated by diverse Chinese non‐state agents in 1903–1949, in relation to the vicissitudes of Chinese nationalism, as a window to look at the mutually constitutive relationship between racism and nationalism in twentieth‐century China. By paralleling Booker T. Washington's colour and his extraordinary success, Chinese intellectuals creatively established a role model that ran counter to the popular expectation of success. While exerting the sense of shame on Chinese, Booker T. Washington's success created unique rhetorical effects to regenerate China's atrophied national spirit that could otherwise not be done by a white figure. It argues that the conscious manoeuvres of Booker T. Washington's Blackness by Chinese intellectuals bring to view the dual contradictoriness embedded in Chinese nationalist thought, tangled and mutually reinforcing; While Chinese intellectuals' implicit adoption of the coloniser's racial ideology confronted their explicit nationalist statements, their celebration of the unique and timeless quality of being Chinese undermined their aspiration to embrace the world culture.
Linking leaf dark respiration to leaf traits and reflectance spectroscopy across diverse forest types
Authors: Wu Fengqi , Liu Shuwen , Lamour Julien , Atkin Owen K. , Yang Nan , Dong Tingting , Xu Weiying , Smith Nicholas G. , Wang Zhihui , Wang Han , Su Yanjun , Liu Xiaojuan , Shi Yue , Xing Aijun , Dai Guanhua , Dong Jinlong , Swenson Nathan G. , Kattge Jens , Reich Peter B. , Serbin Shawn P. , Rogers Alistair , Wu Jin , Yan Zhengbing 
Published: November 2024

Summary
Leaf dark respiration (Rdark), an important yet rarely quantified component of carbon cycling in forest ecosystems, is often simulated from leaf traits such as the maximum carboxylation capacity (Vcmax), leaf mass per area (LMA), nitrogen (N) and phosphorus (P) concentrations, in terrestrial biosphere models. However, the validity of these relationships across forest types remains to be thoroughly assessed.
Here, we analyzed Rdark variability and its associations with Vcmax and other leaf traits across three temperate, subtropical and tropical forests in China, evaluating the effectiveness of leaf spectroscopy as a superior monitoring alternative.
We found that leaf magnesium and calcium concentrations were more significant in explaining cross‐site Rdark than commonly used traits like LMA, N and P concentrations, but univariate trait–Rdark relationships were always weak (r2 ≤ 0.15) and forest‐specific. Although multivariate relationships of leaf traits improved the model performance, leaf spectroscopy outperformed trait–Rdark relationships, accurately predicted cross‐site Rdark (r2 = 0.65) and pinpointed the factors contributing to Rdark variability.
Our findings reveal a few novel traits with greater cross‐site scalability regarding Rdark, challenging the use of empirical trait–Rdark relationships in process models and emphasize the potential of leaf spectroscopy as a promising alternative for estimating Rdark, which could ultimately improve process modeling of terrestrial plant respiration.
Design considerations for development of cuffed endotracheal tube for small airways
Authors: Maguire Seamus , Wade Daniel , Curley James , Morris Sean 
Published: November 2024

AbstractEndotracheal tubes (ETTs) are life‐supporting devices that are designed to maintain a patent airway in patients who are unable to sustain an airway due to illness or injury. Patients with small airways, such as neonates and pediatrics, have unique structural and functional features, making it essential that ETT design considers and executes on these particular needs. Though uncuffed ETTs have historically been preferred for patients younger than eight years of age, advances in cuffed ETT design and construction can be utilized to manufacture ETTs that are optimized for the smallest, most fragile airways. The purpose of this article is to discuss certain design features of cuffed ETTs in respect to small airways.
Shwachman‐Diamond Syndrome Presenting as Neonatal Ichthyosis
Authors: Jacinto‐Calimag Fatima , Wee Lynette Wei Yi , Wen Mildrid Yeo Li , Wei Christopher Ho Wen , Koh Mark Jean‐Aan 
Published: November 2024

ABSTRACTShwachman‐Diamond syndrome (SDS) is a rare inherited bone marrow failure syndrome characterized by the triad of exocrine pancreatic dysfunction, cytopenia, and skeletal abnormalities. We report a 5‐month‐old boy with SDS who presented with generalized ichthyosis in the neonatal period that evolved into more eczematous skin eruptions, accompanied by severe failure to thrive. This report highlights the importance of including SDS as a differential diagnosis in patients who present with early ichthyosis, failure‐to‐thrive, gastrointestinal symptoms and cytopenia.
Dehydration tolerance rather than avoidance explains drought resistance in zoysiagrass
Authors: Simpson Emma , Haverroth Eduardo J. , Taggart Matthew , Andrade Moab T. , Villegas Daniel A. , Carbajal Esdras M. , Oliveira Leonardo A. , Suchoff David , Milla‐Lewis Susana , Cardoso Amanda A. 
Published: November 2024

AbstractIrrigation of grasses dominates domestic water use across the globe, and better understanding of water use and drought resistance in grasses is of undeniable importance for water conservation. Breeding programs have released cultivars with improved drought resistance, but the underlying mechanisms remain unknown. We sought to characterize the mechanisms driving drought resistance in four zoysiagrass cultivars (Lobo, Zeon, Empire, and Meyer) reported to exhibit contrasting levels of drought resistance. A dry‐down was performed through deficit irrigation until 70% decline in evapotranspiration. All cultivars exhibited similar drought avoidance as they dehydrated similarly throughout the drought. Lobo and Zeon, however, exhibited a 70% decline in evapotranspiration two to three days after Empire and Meyer, thus experiencing lower water potentials. Regarding drought tolerance, Lobo and Zeon maintained higher normalized difference vegetation index (NDVI) and lower perceived canopy mortality at higher dehydration levels than Empire and Meyer. We use “perceived” because visual assessments of canopy mortality are influenced by drought‐induced leaf rolling. During the recovery, leaves rehydrated and unrolled, so the “actual” canopy mortality could be evaluated. All cultivars exhibited similar mortality on the first recovery day despite Lobo and Zeon experiencing more severe dehydration. Throughout the recovery, Lobo and Empire exhibited faster re‐growth and showed the lowest canopy mortality, and Lobo exhibited the highest NDVI. The improved drought resistance of Lobo and Zeon results from greater dehydration tolerance rather than avoidance. This study has implications for lawn owners selecting the best cultivars and for breeding programs aiming at improving drought resistance of zoysiagrasses.
Analysis of the binding specificity of N‐acetylgalactosamine (GalNAc)‐binding lectin isolated from Kappaphycus alvarezii to SARS‐CoV‐2 sugar moieties
Authors: Maliki Intan Mariana , Misson Mailin , Teoh Peik Lin , Rodrigues Kenneth Francis , Koh Wee Yin , Yong Wilson Thau Lym 
Published: November 2024

SUMMARYN‐acetylgalactosamine (GalNAc)‐binding lectin is one of the beneficial lectins because it has the ability to bind to glycoproteins or glycolipids containing GalNAc. Its potential applications include use as a drug delivery system, as well as for diagnostic tools and therapeutic interventions. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike proteins are known to be heavily glycosylated, and GalNAc‐binding lectin can potentially bind with these glycoproteins. The present study specifically investigated the interactions between GalNAc‐binding lectin from Kappaphycus alvarezii (Rhodophyta) and the sugars and glycoproteins present on the S protein of the SARS‐CoV‐2 virus. The GalNAc‐specific lectin was successfully isolated from K. alvarezii var. tangan‐tangan (Loving Beauty) and purified using a Sepharose 6B‐GalNAc affinity column. This lectin demonstrated stability within the temperature range 30–80°C and pH range 3–9. The minimum inhibitory concentration of this lectin was determined to be 0.001 mg mL−1. Sugar specificity tests confirmed its ability to bind to the sugars and glycoproteins reported to be present on the S protein of the SARS‐CoV‐2 virus envelope. These results suggest that the potential of GalNAc‐specific lectin from K. alvarezii can be further explored, making it a promising candidate for therapeutic interventions against coronavirus.
Risk of self‐harm and suicide on reaching the age at which a parent died by suicide or other causes: A Danish, population‐based self‐controlled case series study
Authors: Logeswaran Yanakan , McDonald Keltie , Cerel Julie , Lewis Gemma , Erlangsen Annette , Pitman Alexandra 
Published: November 2024

AbstractIntroductionRisk factors for suicide after parental suicide may include points in the lifecourse when reminders of the deceased trigger grief resurgence. We hypothesized that risk of suicide attempt and suicide is elevated among suicide‐bereaved offspring on reaching the age at which a parent died by suicide.MethodsWe conducted a self‐controlled case series (SCCS) study using national register data on all individuals bereaved by parental suicide living in Denmark from 1980 to 2016. We compared relative incidence of our combined outcome (any secondary‐care episode of self‐harm or suicide) during the exposure period (2 years centred on the birthday representing age correspondence) and the 15‐year unexposed periods either side. We repeated these models for offspring bereaved by parental non‐suicide death as an indirect comparison.ResultsRisk of self‐harm or suicide was elevated on reaching the age at parental suicide (n = 188; IRRadj: 2.02, 95% CI: 1.21–3.38) relative to flanking periods, but not at parental non‐suicide death (n = 734; IRRadj: 0.76; 95% CI: 0.39–1.50).ConclusionsReaching the age at which a parent died by suicide appears to represent a vulnerable period for suicidality, countering public perceptions that time heals linearly. This indicates a need for support in the lead up to age correspondence.
Development of a peer‐delivered lethal means counseling intervention for firearm owning veterans: Peer engagement and exploration of responsibility and safety (PEERS)
Authors: Houtsma Claire , Hohman Melinda , Anestis Michael D. , Bryan Craig J. , True Gala 
Published: November 2024

AbstractIntroductionThis study aimed to adapt and expand an evidence‐based lethal means counseling intervention for peer‐delivery among firearm owning Veterans. We further sought to assess Veteran interventionists' fidelity to motivational interviewing (MI) in the context of the adapted intervention.MethodsAn iterative expert panel comprised of experts in suicide prevention, lethal means counseling, MI, and Veteran peer engagement (N = 9) informed intervention adaptation. Experts rated the appropriateness of the adapted intervention, named Peer Engagement and Exploration of Responsibility and Safety (PEERS), and associated interventionist training plan across six criteria. Veteran interventionists (N = 3) were trained to deliver PEERS and their fidelity to MI in the context of PEERS was evaluated.ResultsExpert panelists' average rating was 7.6 (out of 9). Ratings across all criteria (e.g., quality of the training plan; perceived ability of interventionists to engage in the intervention) were high. Interventionists' composite MI fidelity scores suggested most were client‐centered, but not MI‐competent in their delivery.ConclusionFindings suggest that PEERS is an appropriate lethal means counseling intervention for firearm owning Veterans that can be somewhat feasibly delivered by Veteran interventionists. This intervention could help expand the reach and effectiveness of lethal means counseling.
Developing GeoAI Integrated Mass Valuation Model Based on LADM Valuation Information Great Britain Country Profile
Authors: Mete Muhammed Oguzhan 
Published: November 2024

ABSTRACTAccess to information pertaining to land facilitates strategic planning for individuals, businesses, and governmental entities and allows them to anticipate and address contemporary challenges such as climate change, housing requirements, and economic prosperity. Improvements in information technologies contribute to data creation, analysis, and dissemination processes that enable gaining knowledge about land‐related events. Greater use of location data within property technologies gives rise to an efficient and sustainable land administration system. GeoAI can contribute greatly to the solution of spatial problems by extracting information from complex data through geospatial intelligence. Property valuation requires a spatially explicit model to evaluate locational factors with spatial analyses. In this study, a Land Administration Domain Model (LADM)‐based mass valuation model is developed for Great Britain by integrating GeoAI techniques. First, the LADM Valuation Information package is matched with the country's current organizational structure and it is extended according to the needs to create a country profile. After developing the conceptual model, a database schema is created and automatic conversion to the physical model is conducted. Loading different data sources into the database, a mass valuation application is carried out through spatial analysis and Random Forest regression analysis. As a result, a highly accurate and holistic valuation model is implemented based on the international land administration standards.