bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bulk view of teleportation and traversable wormholes
Authors: Bak Dongsu , Kim Chanju , Yi Sang-Heon 
Published: August 2018

Abstract
We construct detailed AdS2 gravity solutions describing the teleportation through a traversable wormhole sending a state from one side of the wormhole to the other. The traversable wormhole is realized by turning on a double trace interaction that couples the two boundaries of an eternal AdS2 black hole. The horizon radius or the entropy of the black hole is reduced consistently with the boundary computation of the energy change, confirming the black hole first law. To describe teleportee states traveling through the wormhole, we construct Janus deformations which make the Hamiltonians of left-right boundaries differ from each other by turning on exact marginal operators. Combining explicitly the traversable wormhole solution and the teleportee states, we present a complete bulk picture of the teleportation in the context of ER=EPR. The traversability of the wormhole is not lost to the leading order of the deformation parameter. We also consider solutions where the teleportee meets the matter thrown from the other side during teleportation, in accordance with the assertion that the bulk wormhole is experimentally observable.
Blockade of Toll-Like Receptor 4 Attenuates Erectile Dysfunction in Diabetic Rats
Authors: Nunes Kenia Pedrosa , de Oliveira Amanda Almeida , Szasz Theodora , Biancardi Vinicia Campana , Webb R. Clinton 
Published: August 2018

Abstract

Introduction
While increased toll-like receptor (TLR)4 activity may contribute to the pathophysiology of vascular diseases, the molecular mechanisms disrupted by this receptor in the vasculature are still poorly understood. Additionally, it is unknown if TLR4 mediates erectile dysfunction (ED) during diabetes.

Aim
To investigate whether pharmacological blockade of TLR4 affects erectile function in a murine model of diabetes.

Methods
Sprague Dawley rats (Charles River Laboratory, Wilmington, MA, USA) received a single streptozotocin injection (65 mg/kg, 28 days) and were treated with an anti-TLR4 antibody (1 μg/d, intraperitoneally) for the last 14 days of the treatment. Additionally, cavernosal strips were acutely incubated for 30 minutes with CLI-095 (10−5 mol/L), a TLR4 inhibitor. Functional studies, Western blotting, erectile function, immunohistochemistry, and biochemical analyses were performed.

Main Outcome Measures
Oxidative stress, cyclic guanosine monophosphate (cGMP) levels, and functional studies were evaluated in treated and nontreated cavernosal strips from control and diabetic animals. Additionally, in vivo erectile function was assessed.

Results
Enhanced TLR4 expression was observed in corpus cavernosum from diabetic rats compared with control animals. Long-term blockade of TLR4 slightly improved diabetes–induced ED in rats due to attenuation of oxidative stress and increased cGMP levels in penile tissue, which ameliorated cavernosal relaxation. Functional experiments revealed that acute or chronic inhibition of TLR4 decreased hypercontractility in response to phenylephrine and improved nitrergic relaxation in corpus cavernosum from diabetic rats.

Clinical Implications
TLR4 blockade may be a novel therapeutic strategy to assist in ED management.

Strengths & Limitations
The strength of this article stems from the fact that we showed that TLR4 blockade partly improves erectile function in vivo in diabetic rats. Its limitations mainly include that messenger RNA analysis for the nitric oxide/cGMP pathway were not performed.

Conclusion
In summary, TLR4 participates in the mechanisms of diabetes-associated ED and blockade of this receptor positively affects penile vascular function.
Prognostic value of immunohistochemically detected p53 in adjuvant chemotherapy‐treated triple negative breast cancer
Authors: Bae Soo Youn , Jung Seung Pil , Lee Se Kyung , Yu Jonghan , Lee Jeong Eon , Kim Seok Won , Nam Seok Jin 
Published: August 2018

AbstractMutations of the p53 gene are the most common genomic alterations associated with triple‐negative breast cancer (TNBC) and are reported in 60–88% cases. Despite the high incidence of such mutations, there is no consensus about the clinical application of p53 detection in breast cancer management. This study investigates the prognostic value of immunohistochemically detected p53 in TNBC patients who received adjuvant chemotherapy. We reviewed the clinicopathologic features of 1088 TNBC patients who received curative surgery and adjuvant chemotherapy. Immunohistochemically, nuclear staining of >10% was defined as p53 “positive.” Of the total 1088 TNBC patients, 709 (65.2%) had no lymph node metastasis (N0). Among the N0 patients, 408 (57.5%) were p53‐ positive (p53+), and 301 (42.5%) were p53‐ negative (p53‐). p53 + tumors showed a tendency for better breast cancer‐specific survival (BCSS, p = 0.052) and overall survival (OS, p = 0.079) compared to p53‐ tumors. In multivariate analysis, p53 + tumors showed significantly better BCSS (p53 + vs. p53‐; HR 2.8, 95% confidence interval: 1.1–7.3, p = 0.034); however, in TNBC patients with lymph node metastasis, there was no correlation between p53 status, clinicopathologic characteristics, and survival. Consequently, in TNBC patients who received adjuvant chemotherapy, immunohistochemical p53 expression was associated with better BCSS in N0 patients.
Jet–flap interaction tones
Authors: Jordan Peter , Jaunet Vincent , Towne Aaron , Cavalieri André V. G. , Colonius Tim , Schmidt Oliver , Agarwal Anurag 
Published: August 2018

Motivated by the problem of jet–flap interaction noise, we study the tonal dynamics that occurs when an isothermal turbulent jet grazes a sharp edge. We perform hydrodynamic and acoustic pressure measurements to characterise the tones as a function of Mach number and streamwise edge position. The observed distribution of spectral peaks cannot be explained using the usual edge-tone model, in which resonance is underpinned by coupling between downstream-travelling Kelvin–Helmholtz wavepackets and upstream-travelling sound waves. We show, rather, that the strongest tones are due to coupling between Kelvin–Helmholtz wavepackets and a family of trapped, upstream-travelling acoustic modes in the potential core, recently studied by Towneet al. (J. Fluid Mech.vol. 825, 2017) and Schmidtet al. (J. Fluid Mech.vol. 825, 2017). We also study the band-limited nature of the resonance, showing the high-frequency cutoff to be due to the frequency dependence of the upstream-travelling waves. Specifically, at high Mach number, these modes become evanescent above a certain frequency, whereas at low Mach number they become progressively trapped with increasing frequency, which inhibits their reflection in the nozzle plane.
Saturation of a turbulent mixing layer over a cavity: response to harmonic forcing around mean flows
Authors: Boujo E. , Bauerheim M. , Noiray N. 
Published: August 2018

Turbulent mixing layers over cavities can couple with acoustic waves and lead to undesired oscillations. To understand the nonlinear aspects of this phenomenon, a turbulent mixing layer over a deep cavity is considered and its response to harmonic forcing is analysed with large-eddy simulations (LES) and linearised Navier–Stokes equations (LNSE). The Reynolds number is $Re=150\,000$. As a model of incoming acoustic perturbations, spatially uniform time-harmonic velocity forcing is applied at the cavity end, with amplitudes spanning the wide range 0.045–8.9 % of the main channel bulk velocity. Compressible LES provide reference nonlinear responses of the shear layer, and the associated mean flows. Linear responses are calculated with the incompressible LNSE around the LES mean flows; they predict well the amplification (both measured with kinetic energy and with a proxy for vortex sound production in the mixing layer) and capture the nonlinear saturation observed as the forcing amplitude increases and the mixing layer thickens. Perhaps surprisingly, LNSE calculations based on a monochromatic (single-frequency) assumption yield a good agreement even though higher harmonics and their nonlinear interaction (Reynolds stresses) are not negligible. However, it is found that the leading Reynolds stresses do not force the mixing layer efficiently, as shown by a comparison with the optimal volume forcing obtained from a resolvent analysis. Therefore they cannot fully benefit from the potential for amplification available in the flow. Finally, the sensitivity of the optimal harmonic forcing at the cavity end is computed with an adjoint method. The sensitivities to mean flow modification and to a localised feedback (structural sensitivity) both identify the upstream cavity corner as the region where a small-amplitude modification has the strongest effect. This can guide in a systematic way the design of strategies aiming at controlling the amplification and saturation mechanisms.
Effect of vitamin D supplementation on depressive symptoms and psychological wellbeing in healthy adult women: a double-blind randomised controlled clinical trial
Authors: Choukri Maria A. , Conner Tamlin S. , Haszard Jill J. , Harper Michelle J. , Houghton Lisa A. 
Published: August 2018

AbstractEpidemiological evidence has linked low vitamin D status to a range of mood disorders. However, studies examining whether vitamin D supplementation can improve mood-related outcomes in healthy populations are limited. We investigated whether vitamin D supplementation over winter is beneficial for improving mood-related outcomes in healthy women. A total of 152 healthy women (18–40 years) in Dunedin, New Zealand were randomly assigned to receive 50 000 IU (1·25 mg) of oral vitamin D3 or placebo once per month for 6 months. They completed the Center for Epidemiologic Studies Depression Scale, the anxiety subscale of the Hospital Anxiety and Depression Scale and the Flourishing Scale every month. Additionally, they reported their positive and negative mood each day for three consecutive days every 2 months. Participants provided a blood sample at the beginning and at the end of the study for 25-hydroxyvitamin D3 analysis. ANCOVA was used to compare the outcome measures between the groups, controlling for baseline. We found no evidence of lower depression (P = 0·339), lower anxiety (P = 0·862), higher flourishing (P = 0·453), higher positive moods (P = 0·518) or lower negative moods (P = 0·538) in the treatment group compared with the control group at follow-up. Mood outcomes over the study period were similar for the two groups. We found no evidence of any beneficial effect of monthly vitamin D3 supplementation on mood-related outcomes in healthy premenopausal women over the winter period, so recommendations for supplementations are not warranted in this population for mood-related outcomes.
Predictors of the immune response to booster immunisation against tetanus in Czech healthy adults
Authors: Petráš M. , Oleár V. 
Published: August 2018

AbstractAn evaluation of the relationship between predictors and immune response was conducted using data obtained from a clinical trial in 200 Czech healthy adults aged 24–65 years receiving a booster dose of a monovalent tetanus vaccine in 2017. The response was determined from ELISA antibody concentrations of paired sera obtained before and 4 weeks after the immunisation. While all subjects with initial antibody levels <1.2 IU/ml achieved a 100% seroconversion rate (at least a fourfold rise in antibodies), only 8% seroconversion was documented in subjects with initial levels >2.2 IU/ml. The immune response was not affected by sex, age, tetanus vaccine type, concomitant medication, related adverse events or post-vaccination period since there were no significant differences in geometric mean concentrations or seroconversion rates. The seroconversion rate of 56% in smokers was significantly lower than that of 73% achieved in non-smokers. Although the seroconversion rates did not differ between individuals with normal or higher body weight, the adjusted odds ratio (1.3; 95% Cl 1.08–1.60) revealed a positive correlation between seroconversion rate and body mass index (BMI). Although the vaccine-induced response was influenced by pre-vaccination antibody levels, smoking or BMI, the booster immunisation against tetanus produced a sufficient response regardless the predictors.
True Polar Wander: A Key Indicator for Plate Configuration and Mantle Convection During the Late Neoproterozoic
Authors: Robert Boris , Greff‐Lefftz Marianne , Besse Jean 
Published: August 2018

AbstractLarge polar motions are observed in the apparent polar wander paths of several continents during the Ediacaran. Among various hypotheses proposed in the literature, one consists of the occurrence of two successive fast and large true polar wander (TPW) episodes, from 615 to 590 Ma and then between 575 and 565 Ma. In this study, we explored the effect of the reactivation of a girdle of subduction to produce such TPW. First, we performed a reconstruction of the main continents between 615 and 520 Ma including Laurentia, Baltica, west and central Gondwana, and Australia‐Antarctica. We then implemented this paleogeography into a simple mantle dynamic model to calculate the TPW during the Ediacaran. Our results show that the reactivation of a girdle of subduction surrounding the continents along with a reduced effect of the return flow rising from the lower mantle can produce two TPW episodes consistent with the paleomagnetic observations. This mechanism is possible if the sinking velocities associated with the girdle of subduction drastically decrease between 635 and 730 Ma. Such a large geodynamic event is consistent with the detrital zircon age distribution of the Neoproterozoic supporting a low subduction activity during the Cryogenian and a boost during the Ediacaran. Decrease of subduction‐related stress induced on the lithosphere may have interrupted the rifting of the supercontinent Rodinia for 100 Ma. Finally, the weakening in subduction magmatism might have strongly reduced the CO2 flux into the atmosphere and played a major role in driving the Neoproterozoic global‐scale glaciations.
Observations and Modeling of Traveling Ionospheric Disturbance Signatures From an Australian Network of Oblique Angle‐of‐Arrival Sounders
Authors: Heitmann Andrew J. , Cervera Manuel A. , Gardiner‐Garden Robert S. , Holdsworth David A. , MacKinnon Andrew D. , Reid Iain M. , Ward Bruce D. 
Published: August 2018

AbstractA network of oblique angle‐of‐arrival (AoA) ionosondes was installed as part of the Elevation‐scanned Oblique Incidence Sounder Experiment (ELOISE) in September 2015. The ELOISE experimental campaign was designed to study the spatial and temporal structure of ionospheric variability at midlatitudes, of which traveling ionospheric disturbances are a key component. The new AoA sounder makes use of Defence Science and Technology Group's direct‐digital high‐frequency transmitter and receiver technology, to enable multichannel collection of both ionograms and channel scattering functions (Doppler spectra) on a common 2‐D array. In this paper, the array design and onboard signal processing for the AoA sounder is described, along with a sample of results showing typical disturbance signatures across the delay, Doppler frequency, bearing, and elevation measurements. Realistic parameterized models of electron density perturbations, along with geometric ray tracing, were used to synthesize the effects of medium‐ to large‐scale traveling ionospheric disturbances on the sounder observables and aid in interpreting the measured signatures.
A power supply module for autonomous portable electronics: ultralow-frequency MEMS electrostatic kinetic energy harvester with a comb structure reducing air damping
Authors: Lu Yingxian , Marty Frédéric , Galayko Dimitri , Laheurte Jean-Marc , Basset Philippe 
Published: August 2018

AbstractA MEMS electrostatic kinetic energy harvester (e-KEH) of about 1 cm2, working at ultralow frequency (1–20 Hz), without any supported additional mass on its mobile electrode, and working even without a vacuum environment is reported. The prototype is especially suitable for environments with abundant low frequency motions such as wearable electronics. The proposed e-KEH consists of a capacitor with a finger-teeth interdigited comb structure. This greatly reduces the air damping effect, and thus the capacitance variation remains important regardless of the presence of air. With the new design, the energy transduced per cycle of excitation is no less than 33 times higher than the classic design within 10–40 Hz/2 gpeak, while is 85 times higher at 15 Hz/2 gpeak. An enclosed miniature ball combined with non-linear stoppers enables the oscillation of the movable electrode through impact-based frequency up-conversion mechanism, which is also improved by the low air damping. Thanks to this new design, a higher efficiency than the classic gap-closing comb structure is obtained, as a larger range of working frequency (1–180 Hz) in air. A maximum energy conversion of 450 nJ/cycle is obtained with a bias voltage of 45 V and an acceleration of 11 Hz, 3 gpeak. Working with a diode AC-DC rectifier, the proposed KEH is able to support up to 3 RFID communications within 16 s while operated at 11 Hz, 3 gpeak.
Common and differential transcriptional responses to different models of traumatic stress exposure in rats
Authors: Jacobson Moriah L. , Kim Lydia A. , Patro Robert , Rosati Barbara , McKinnon David 
Published: August 2018

AbstractThe effect of six different traumatic stress protocols on the transcriptome of the rat adrenal gland was examined using RNA sequencing. These protocols included chronic variable stress, chronic shock, social defeat and social isolation. The response of the transcriptome to stress suggested that there are genes that respond in a universal or stress modality-independent manner, as well as genes that respond in a stress modality-specific manner. Using a small number of the genes selected from the modality-independent set of stress-sensitive genes, a sensitive and robust measure of chronic stress exposure was developed. This stress-sensitive gene expression (SSGE) index could detect chronic traumatic stress exposure in a wide range of different stress models in a manner that was relatively independent of the modality of stress exposure and that paralleled the intensity of stress exposure in a dose-dependent manner. This measure could reliably distinguish control and stressed individuals in the case of animals exposed to the most intense stress protocols. The response of a subset of the modality-specific genes could also distinguish some types of stress exposure, based solely on changes in the pattern of gene expression. The results suggest that it is possible to develop diagnostic measures of traumatic stress exposure based solely on changes in the level of expression of a relatively small number of genes.
High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis
Authors: Xu Xingbo , Tan Xiaoying , Tampe Björn , Wilhelmi Tim , Hulshoff Melanie S. , Saito Shoji , Moser Tobias , Kalluri Raghu , Hasenfuss Gerd , Zeisberg Elisabeth M. , Zeisberg Michael 
Published: August 2018

AbstractWhile suppression of specific genes through aberrant promoter methylation contributes to different diseases including organ fibrosis, gene-specific reactivation technology is not yet available for therapy. TET enzymes catalyze hydroxymethylation of methylated DNA, reactivating gene expression. We here report generation of a high-fidelity CRISPR/Cas9-based gene-specific dioxygenase by fusing an endonuclease deactivated high-fidelity Cas9 (dHFCas9) to TET3 catalytic domain (TET3CD), targeted to specific genes by guiding RNAs (sgRNA). We demonstrate use of this technology in four different anti-fibrotic genes in different cell types in vitro, among them RASAL1 and Klotho, both hypermethylated in kidney fibrosis. Furthermore, in vivo lentiviral delivery of the Rasal1-targeted fusion protein to interstitial cells and of the Klotho-targeted fusion protein to tubular epithelial cells each results in specific gene reactivation and attenuation of fibrosis, providing gene-specific demethylating technology in a disease model.
Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding
Authors: Liu Wenting , Zhong Yi-Fang , Liu Liu-Yi , Shen Chu-Tong , Zeng Wenjuan , Wang Fuyi , Yang Danzhou , Mao Zong-Wan 
Published: August 2018

AbstractDNA G-quadruplexes are not only attractive drug targets for cancer therapeutics, but also have important applications in supramolecular assembly. Here, we report a platinum(II)-based tripod (Pt-tripod) specifically binds the biological relevant hybrid-1 human telomeric G-quadruplex (Tel26), and strongly inhibits telomerase activity. Further investigations illustrate Pt-tripod induces the formation of monomeric and multimeric Pt-tripod‒Tel26 complex structures in solution. We solve the 1:1 and the unique dimeric 4:2 Pt-tripod–Tel26 complex structures by NMR. The structures indicate preferential binding of Pt-tripod to the 5ʹ-end of Tel26 at a low Pt-tripod/Tel26 ratio of 0–1.0. After adding more Pt-tripod, the Pt-tripod binds the 3ʹ-end of Tel26, unexpectedly inducing a unique dimeric 4:2 structure interlocked by an A:A non-canonical pair at the 3ʹ-end. Our structures provide a structural basis for understanding the dynamic binding of small molecules with G-quadruplex and DNA damage mechanisms, and insights into the recognition and assembly of higher-order G-quadruplexes.
Role of hydrogen bonding in hysteresis observed in sorption-induced swelling of soft nanoporous polymers
Authors: Chen Mingyang , Coasne Benoit , Guyer Robert , Derome Dominique , Carmeliet Jan 
Published: August 2018

AbstractHysteresis is observed in sorption-induced swelling in various soft nanoporous polymers. The associated coupling mechanism responsible for the observed sorption-induced swelling and associated hysteresis needs to be unraveled. Here we report a microscopic scenario for the molecular mechanism responsible for hysteresis in sorption-induced swelling in natural polymers such as cellulose using atom-scale simulation; moisture content and swelling exhibit hysteresis upon ad- and desorption but not swelling versus moisture content. Different hydrogen bond networks are examined; cellulose swells to form water–cellulose bonds upon adsorption but these bonds do not break upon desorption at the same chemical potential. These findings, which are supported by mechanical testing and cellulose textural assessment upon sorption, shed light on experimental observations for wood and other related materials.
Revisiting the functional significance of binocular cues for perceiving motion-in-depth
Authors: Kohler Peter J. , Meredith Wesley J. , Norcia Anthony M. 
Published: August 2018

AbstractBinocular differencing of spatial cues required for perceiving depth relationships is associated with decreased sensitivity to the corresponding retinal image displacements. However, binocular summation of contrast signals increases sensitivity. Here, we investigated this divergence in sensitivity by making direct neural measurements of responses to suprathreshold motion in human adults and 5-month-old infants using steady-state visually evoked potentials. Interocular differences in retinal image motion generated suppressed response functions and correspondingly elevated perceptual thresholds compared to motion matched between the two eyes. This suppression was of equal strength for horizontal and vertical motion and therefore not specific to the perception of motion-in-depth. Suppression is strongly dependent on the presence of spatial references in the image and highly immature in infants. Suppression appears to be the manifestation of a succession of spatial and interocular opponency operations that occur at an intermediate processing stage either before or in parallel with the extraction of motion-in-depth.