bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation using Targeted RNA-sequencing
Authors: Grandjean Julia M.D. , Plate Lars , Morimoto Richard I. , Bollong Michael J. , Powers Evan T. , Wiseman R. Luke 
Published: December 2018

ABSTRACTCellular proteostasis is maintained by stress-responsive signaling pathways such as the heat shock response (HSR), the oxidative stress response (OSR), and the unfolded protein response (UPR). Activation of these pathways results in the transcriptional upregulation of select subsets of stress-responsive genes that restore proteostasis and adapt cellular physiology to promote recovery following various types of acute insult. The capacity for these pathways to regulate cellular proteostasis makes them attractive therapeutic targets to correct proteostasis defects associated with diverse diseases. High-throughput screening (HTS) using cell-based reporter assays is highly effective for identifying putative activators of stress-responsive signaling pathways. However, the development of these compounds is hampered by the lack of medium-throughput assays to define compound potency and selectivity for a given pathway. Here, we describe a targeted RNA sequencing (RNAseq) assay that allows cost effective, medium-throughput screening of stress-responsive signaling pathway activation. We demonstrate that this assay allows deconvolution of stress-responsive signaling activated by chemical genetic or pharmacologic agents. Furthermore, we use this assay to define the selectivity of putative OSR and HSR activating compounds previously identified by HTS. Our results demonstrate the potential for integrating this adaptable targeted RNAseq assay into screening programs focused on developing pharmacologic activators of stress-responsive signaling pathways.
ATP7B variant penetrance explains differences between genetic and clinical prevalence estimates for Wilson disease
Authors: Wallace Daniel F. , Dooley James S. 
Published: December 2018

AbstractWilson disease (WD) is a genetic disorder of copper metabolism caused by variants in the copper transporting P-type ATPase gene ATP7B. Estimates for WD population prevalence vary with 1 in 30,000 generally quoted. However, some genetic studies have reported much higher prevalence rates. The aim of this study was to estimate the population prevalence of WD and the pathogenicity/penetrance of WD variants by determining the frequency of ATP7B variants in a genomic sequence database. A catalogue of WD-associated ATP7B variants was constructed and then frequency information for these was extracted from the gnomAD dataset. Pathogenicity of variants was assessed by (a) comparing gnomAD allele frequencies against the number of reports for variants in the WD literature and (b) using variant effect prediction algorithms. 231 WD-associated ATP7B variants were identified in the gnomAD dataset, giving an initial estimated population prevalence of around 1 in 2400. After exclusion of WD-associated ATP7B variants with predicted low penetrance, the revised estimate showed a prevalence of around 1 in 20,000, with higher rates in the Asian and Ashkenazi Jewish populations. Reanalysis of other recent genetic studies using our penetrance criteria also predicted lower population prevalences for WD in the UK and France than had been reported. Our results suggest that differences in variant penetrance can explain the discrepancy between reported epidemiological and genetic prevalences of WD. They also highlight the challenge in defining penetrance when assigning causality to some ATP7B variants.
Assessment of a small UAV speed polar graph by conducting flight tests
Authors: Tomaszewski Adam , Goraj Zdobyslaw Jan 
Published: December 2018

Purpose
The purpose of this paper is to present an approach to a polar graph measurement by a flight testing technique and to propose a baseline research method for future tests of UAV polar graphs. The method presented can be used to demonstrate a conceptual and preliminary design process using a scaled, unmanned configuration. This shows how results of experimental flight tests using a scaled flying airframe may be described and analysed before manufacturing the full scale aircraft.

Design/methodology/approach
During the research, the flight tests were conducted for two aerodynamic configurations of a small UAV. This allowed the investigation of the influence of winglets and classic vertical stabilizers on the platform stability, performance and therefore polar graphs of a small unmanned aircraft.

Findings
A methodology of flight tests for the assessment of a small UAV’s polar graph has been proposed, performed and assessed. Two aerodynamic configurations were tested, and it was found that directional stability had a large influence on the UAV’s performance. A correlation between the speed and inclination of the altitude graph was found – i.e. the higher the flight speed, the steeper the altitude graph (higher descent speed, steeper flight path angle). This could be considered as a basic verification that the recorded data have a physical sense.

Practical implications
The polar graph and therefore glide ratio of the aircraft is a major factor for determining its performance and power required for flight. Using the right flight test procedure can speed-up the process of measuring glide ratio, making it easier, faster, robust, more effective and accurate in future research of novel, especially unorthodox configurations. This paper also can be useful for the proper selection of requirements and preliminary design parameters for making the design process more economically effective.

Originality/value
This paper presents a very efficient method of assessing the design parameters of UAVs, especially the polar graph, in an early stage of the design process. Aircraft designers and producers have been widely performing flight testing for years. However, these procedures and practical customs are usually not wide spread and very often are treated as the company’s “know how”. Results presented in this paper are original, relatively easily be repeated and checked. They may be used either by professionals, highly motivated individuals and representatives of small companies or also by ambitious amateurs.
New design for reducing interfacial stresses of reinforced structures with FRP plates
Authors: Belabed Youssouf , Kerboua Bachir , Tarfaoui Mostapha 
Published: December 2018

Purpose
The sustainability of the structures is not only a technical goal, but also a matter of social and environmental values. This requires the researchers to use very rigid, highly durable and corrosion-resistant composite structures in order to achieve the technical, environmental and social goals. The purpose of this paper is to present an original work on reducing the interfacial stresses of bonded structures with fibre-reinforced polymers (FRP) plates based on new taper design.

Design/methodology/approach
In this proposed concept, the effect of combined taper is investigated on reducing interfacial stresses, attempting to enhance the structure performance and address the debonding problem that comes with reinforcing techniques. This research is carried out by using finite element analysis, incorporating many new parameters.

Findings
As a result, a new solution is discovered that combined taper in both adhesive layer and composite laminate, which significantly reduces the interfacial stresses at the end of the FRP plate. Additionally, a parametric study is carried out in order to determine the optimal configurations of taper dimensions as well as other parameters that influence the stress concentration distribution at the edge of the adherends.

Practical implications
This new design regarding the reduction of interfacial stresses will help in increasing the lifespan of damaged structures reinforced by FRP composites, preserving thus its technical, historical and social values.

Originality/value
The paper uses straight, concave and convex fillets with inverse taper as a new design solution with new parameters including thermo-mechanical loads and pre-stressed FRP plate with multi-layer, fibre orientation and shear-lag effects.
Identification of effective safety risk mitigating factors for well control drilling operation
Authors: Asad Muhammad Mujtaba , Hassan Razali Bin , Sherwani Fahad , Abbas Zaheer , Shahbaz Muhammad Saeed , Soomro Qadir Mehmood 
Published: December 2018

Purpose
Every year, hundreds of people have died and thousands have been injured because of insufficient management of well control at oil and gas drilling and production sites. Major causes which have been reported in previous studies included uncontrollable blowouts and failure of blowout preventers because of insufficient safety practices. These onshore and offshore blowout disasters not only harm the work force but also critically affect the environment and marine life. In this research paper, a detailed quantitative survey and qualitative risk assessments (RA) have been carried out for assessing the potentially hazardous activities associated with well control along with their appropriate controls and risk reduction factors and mitigating measures in Middle East and south East Asian countries.

Design/methodology/approach
The sequential explanatory research design has been adopted in this study. Whereas, descriptive statistical approach has been used for the quantitative data analysis of this study. While, in-depth interview approach has been used for qualitative data collection. Similarly, what-if analysis method has been adopted in this study for the identification of effective safety and health risk mitigating factors because it provides in-depth information from health and safety environment experts.

Findings
The cumulative quantitative results based on the response from Saudi Arabian drilling industry have indicated that the well control operation is highly hazardous then Malaysian and Pakistani oil and gas industries. Likewise, findings from what-if analysis approach demonstrate that the drilling crewmembers have repetitively faced life threatening hazards which occur (safety and chemical) during well control onshore and offshore operation because of oil base mud, confined space at site, pinch points and falling during working on blow out preventers. According to the overall result, respondents have highly recommended engineering and administrative hazard controlling factors as most suitable for the elimination of safety and chemical hazards during well control activities.

Practical implications
Besides, the developed methodological framework for the identification of suitable hazard controls can also be effectively used for potential hazards reorganization and identification of suitable hazard controls for other drilling and production industries and regions for accident prevention and safety and health management.

Originality/value
This is a first comparative research study which has been carried out in Malaysian, Saudi Arabian and Pakistani onshore and offshore oil and gas industries for well control health and safety management and reorganization of most effective hazards mitigating factors at drilling sites.
The invention of the shopping mall
Authors: Styhre Alexander 
Published: December 2018

Purpose
The economic system of competitive capitalism strives toward liquid markets wherein the cost for transacting is minimized. Liquidity is mostly addressed in association with abstract markets (e.g. the securities market), but also consumer markets are determined by liquidity concerns. The purpose of this paper is to examine the shopping mall concept, developed by the architect and social reformer Victor Gruen during the early 1950s, as a form of production of capitalist space, intended to reduce transaction costs. As an auxiliary benefit, Gruen envisioned the shopping mall as a cultural and civic center in the midst of the satellite town of suburbia, the new site of urban expansion during the post-war boom decades.

Design/methodology/approach
The paper reviews secondary literature on the historical development of the shopping mall as a consumer space. In addition, relevant economic and social science literature is referenced.

Findings
The architecture, design, ornamentation and day-to-day management of the shopping mall were premised on a consumerist way of life, ultimately serving as an all-too-visual index of the triumph of competitive capitalism in the cold war era. However, Gruen’s accomplishments were gradually compromised by the interest of money-minded developers and construction industry actors, and the shopping mall arguably never fulfilled the social and cultural function that Gruen anticipated. Regardless of such outcomes, the production of capitalist space as scripted by Gruen is still determining everyday life in consumer society, making Gruen a key figure, albeit only limitedly recognized, in the history of late modern society and in the capitalist economy.

Originality/value
The paper emphasizes the role of Victor Gruen in the post-Second World War period, being one of the most influential practitioners and social reformers in the era. Furthermore, the paper stresses how market liquidity is a key concern in Gruen’s project to create a communal space for the American suburban population in the era of the expanding welfare state.
Determinants of dividend payout of construction companies: a panel data analysis
Authors: Singla Harish Kumar , Samanta Pradeepta Kumar 
Published: December 2018

Purpose
This paper aims to examine the determinants of the dividend policy of the construction companies in India.

Design/methodology/approach
Data from 2011 to 2016 (six years) of 45 listed construction companies in India are collected, and a strong balanced panel is created. Dividend per share is dependent variable, and profitability, unstable earnings, institutional holding, cash flow, tangibility, liquidity, growth opportunities, age of the firm, life cycle, leverage, size of firm and taxation are explanatory variables. The panel is tested for stationarity and finally fixed and random-effect panel regression model with robust estimation option is performed.

Findings
The random effect model is found fit with an R2 of 62 per cent, and profitability, life cycle and size of the firm show a significant positive effect on dividend payment. Cash flow shows a negative significant relationship, indicating the presence of agency problem. Rest of the variables indicated an insignificant relationship.

Research limitations/implications
The study is carried out on a small sample of 45 companies with data of only six years. Further, there may be behavioral and psychological factors that drive the decision to declare dividend. Those factors have not been considered in present study. Despite considerable efforts, the author could not find more studies specific to the construction sector. Hence, the variables identified in the present study are more generic, even though a few sector-specific studies have been included.

Originality/value
The dividend policy determinants for the construction sector in India are investigated, and a comprehensive model based on 12 explanatory variables is tested to find the drivers of dividend payout in Indian construction companies. From the investor’s point of view, the sector has immense potential in terms of dividend as well as capital appreciation. Therefore, the study can be useful to the investors to understand the drivers of dividend payout in the construction sector. It can also be crucial for companies to create an appropriate dividend policy so as to attract and retain investors. The study contributes significantly to the existing body of knowledge by recommending the salient drivers of dividend payout in the construction sector based on a comprehensive dataset and using robust methodology.
Characterization of SAC – x NiO nano-reinforced lead-free solder joint in an ultra-fine package assembly
Authors: Che Ani Fakhrozi , Jalar Azman , Saad Abdullah Aziz , Khor Chu Yee , Abas Mohamad Aizat , Bachok Zuraihana , Othman Norinsan Kamil 
Published: December 2018

Purpose
This study aims to investigate the NiO nano-reinforced solder joint characteristics of ultra-fine electronic package.

Design/methodology/approach
Lead-free Sn-Ag-Cu (SAC) solder paste was mixed with various percentages of NiO nanoparticles to prepare the new form of nano-reinforced solder paste. The solder paste was applied to assemble the ultra-fine capacitor using the reflow soldering process. A focussed ion beam, high resolution transmission electron microscopy system equipped with energy dispersive X-ray spectroscopy (EDS) was used in this study. In addition, X-ray inspection system, field emission scanning electron microscopy coupled with EDS, X-ray photoelectron spectroscopy (XPS) and nanoindenter were used to analyse the solder void, microstructure, hardness and fillet height of the solder joint.

Findings
The experimental results revealed that the highest fillet height was obtained with the content of 0.01 Wt.% of nano-reinforced NiO, which fulfilled the reliability requirements of the international IPC standard. However, the presence of the NiO in the lead-free solder paste only slightly influenced the changes of the intermetallic layer with the increment of weighted percentage. Moreover, the simulation method was applied to observe the distribution of NiO nanoparticles in the solder joint.

Originality/value
The findings are expected to provide a profound understanding of nano-reinforced solder joint’s characteristics of the ultra-fine package.
Investigating the role of EFQM enablers in innovation performance
Authors: Kafetzopoulos Dimitrios , Gotzamani Katerina 
Published: December 2018

Purpose
The purpose of this paper is to develop a conceptual framework to investigate how the European Foundation for Quality Management (EFQM) excellence model enablers influence the four types (product, process, organizational and marketing) of innovation performance of a manufacturing firm.

Design/methodology/approach
The study uses survey data from a sample of 580 manufacturing firms in Greece and employs structural equation modeling to test the developed hypotheses.

Findings
The results reveal that enablers of the EFQM model are either directly or indirectly associated with the four types of innovation. Furthermore, the findings show that it is essential for a firm to manage all the facilitating enablers included in the EFQM model, since they cannot boost innovation when implemented in isolation.

Research limitations/implications
The sample is limited to one country (Greece). In addition, researchers have to assess the same relationships considering the effect of external factors such as environmental uncertainty. The potential consequences of enablers on innovation performance may be mediated by customer or people results.

Practical implications
The empirical findings of the present study help managers to develop the appropriate quality strategies and allocate the respective resources according to the desired type of innovation.

Originality/value
Based on the multi-dimensional structure of quality, this empirical study determines the contribution of EFQM model enablers to specific innovation performance dimensions of manufacturing companies.
Asocial memories, ‘poisonous knowledge’, and haunting in Mongolia
Authors: Buyandelger Manduhai 
Published: December 2018

AbstractThis article argues that memories that come from contexts that are adversarial, and that are not always based on communication and sociality, should be better integrated within the existing theories of social memory. Shamans in postsocialist Mongolia claim that previously suppressed origin spirits demand that their descendants become initiated as shamans in exchange for ceasing to harass them for forgetting and abandonment. Some clients refuse to become initiated as shamans and thus choose to sever their relationship with their past. In this article I explore one such refusal, which led to a disintegration of existing social ties, while also yielding unexpected memories. These memories are different from the shared memories that emerge in the context of organized shamanic rituals. Circulated through rumour and supposition instead of positive sociality and sharing, these ‘asocial’ memories also act as a particular kind of ‘poisonous knowledge’, prompting each individual to withdraw from the network as a way of avoiding the alleged harm from unattended spirits. Owing to divergent subject positioning, where one person's remembering is another's forgetting, the haunting by unwanted memories continues, as resolution through unifying communal ritual is not possible.
Banishment
Authors: Torres Jose A. , Apkarian Jacob 
Published: December 2018

Research SummaryWe test the degree to which a public housing banishment policy specifically deters overall drug and violent offenses in public housing using a stratified sample of 345 individuals, banned between 2004 and 2012, in one public housing authority (PHA). We find that individual offending (trespass, drug, violent, gun, and property offenses) in public housing increases after being banned. Increases in trespass offenses, specifically for male offenders with limited history of offending prior to being banned, primarily explain the increases. Being banned, however, significantly reduced drug and violent offending for individuals with histories of drug and violent offending in public housing. These individuals were arrested when they were banned, which suggests to us that bans alone may not reduce drug and violent offending.Policy ImplicationsBanishment enforcement should be tailored toward drug and violent offenders using focused deterrence strategies. Targeted enforcement could minimize the harm done to those who are violating bans with legitimate reasons for being in public housing, such as those fulfilling familial obligations, while still producing crime reduction benefits. As a benefit, these changes may increase police legitimacy among public housing residents as they watch police in their communities provide fair and meaningful solutions as it relates to crime brought on by nonresidents.
Network analysis for co‐occurrence of pest insects on host crops
Authors: Do Yuno , Choi Moon Bo 
Published: December 2018

AbstractIn this study, the co‐occurrence patterns of 618 pest insects for 47 host crops, including vegetables, grains, and fruits, were identified. To identify the pest co‐occurrence patterns for various crops, and the interactions among the pest insects and crops, we employed social network analysis methods. We used three traditional centrality measures (degree, closeness, and eigenvector) to determine the relative significance of each crop and pest as a node in the network. Throughout the network analysis, crops and pest nodes were divided into six groups, based on modularity. Crops in the same group could be considered as alternate hosts for pests from the same group. There were clear differences in the cultural practices between groups (i.e., dryland farming versus wetland farming). This indicated that dryland crop pests do not use wetland crops as resources. Pome fruit trees, such as apple and pear, had high centrality indices, which indicated the importance of these crops in the network and their high vulnerability to damage by a multitude of pests. In this study, although it was assumed that all crops were cultivated on the same piece of land during a single growing season, the complex interactions between the whole units were visualized and analyzed as a computable network.