bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute kidney injury after high dose etoposide phosphate: A retrospective study in children receiving an allogeneic hematopoetic stem cell transplantation
Authors: Barnoud Delphine , Pinçon Claire , Bruno Bénédicte , Béné Johana , Gautier Sophie , Lahoche Annie , Petitpain Nadine , Vasseur Michèle , Barthélémy Christine , Décaudin Bertrand , Simon Nicolas , Odou Pascal 
Published: March 2018

AbstractBackgroundEtoposide phosphate (EP; single injection, 60 mg/kg) followed by total body irradiation (TBI) at 12 Gy has been used as an allogeneic stem cell transplantation (allo‐SCT) conditioning regimen for children since 2010. In our institution, EP has been suspected of leading to acute nephrotoxicity. The aim of this study was to assess the potential renal toxicity of EP in this context.Materials and methodsA retrospective study was carried out on children hospitalized between 2007 and 2015 for allo‐SCT with TBI‐based myeloablative conditioning associated with cyclophosphamide (CY, 60 mg/kg/day × 2 days) or EP. The primary endpoint of the study was the occurrence of acute kidney injury (AKI). Additional endpoints were time to recovery for children with AKI, survival, and treatment‐related mortality.ResultsThirty‐five patients were analyzed (CY: 22 vs. EP: 13). AKI occurred more frequently in the EP group than in the CY one (69% vs. 27%, adjusted odds ratio 6.0, 95% confidence interval [CI] [1.145; 31.445], P = 0.03). The median time to recovery was estimated at 3 days, 95% CI (2; 17), with CY and 11 days 95% CI (5; 18) with EP (adjusted hazard ratio of recovery for EP vs. CY 0.262, 95% CI [0.071; 0.969], P = 0.04). No significant difference was highlighted between the two treatments for survival or for treatment‐related mortality.DiscussionThis study shows that EP at high dosage or one of its excipients is probably responsible for AKI, as compared to CY. Further studies are required to explore the origin of this adverse effect.
Obesity, sedentary lifestyle, and video games: The new thrombophilia cocktail in adolescents
Authors: Kohorst Mira A. , Warad Deepti M. , Nageswara Rao Amulya A. , Rodriguez Vilmarie 
Published: March 2018

AbstractRates of venous thromboembolism have increased in the adolescent population over the last two decades, likely due to advanced diagnostics, increased use of central venous catheters, chronic medical conditions, obesity, and oral contraceptive use. Of these factors, a modifiable risk factor for adolescents is obesity. Sedentary lifestyle and prolonged immobilization are additional prothrombotic risk factors that are often associated with obesity. With ever‐increasing screen time, sedentary behavior has risen accordingly, especially among gamers. We present four cases of adolescents who developed life‐threatening venous thromboembolic events in the setting of obesity, sedentary lifestyle and/or immobilization, and prolonged video game use.
Physiological and iTRAQ‐Based Quantitative Proteomics Analysis of Methyl Jasmonate–Induced Tolerance in Brassica napus Under Arsenic Stress
Authors: Farooq Muhammad Ahsan , Zhang Kangni , Islam Faisal , Wang Jian , Athar Habib U. R. , Nawaz Aamir , Ullah Zafar Zafar , Xu Jianxiang , Zhou Weijun 
Published: March 2018

AbstractBrassica napus plants exposed to 200 μM arsenic (As) exhibited high‐level of stress condition, which led to inhibited growth, enhanced lipid peroxidation, and disrupted cellular ultrastructures. Exogenous application of methyl jasmonate (MeJA) alleviated the As‐induced oxidative stress and improved the plant growth and photosynthesis. In this study, changes in the B. napus leaf proteome are investigated in order to identify molecular mechanisms involved in MeJA‐induced As tolerance. The study identifies 177 proteins that are differentially expressed in cultivar ZS 758; while 200 differentially expressed proteins are accumulated in Zheda 622, when exposed to As alone and MeJA+As treatments, respectively. The main objective was to identify the MeJA‐regulated protein under As stress. Consistent with this, iTRAQ detected 61 proteins which are significantly accumulated in ZS 758 leaves treated with MeJA under As stress. While in Zheda 622, iTRAQ detected 49 MeJA‐induced proteins under As stress. These significantly expressed proteins are further divided into five groups on the base of their function, that is, stress and defense, photosynthesis, carbohydrates and energy production, protein metabolism, and secondary metabolites. Taken together, this study sheds light on the molecular mechanisms involved in MeJA‐induced As tolerance in B. napus leaves and suggests a more active involvement of MeJA in plant physiological processes.
Quantitative Proteomic Analysis of Staphylococcus aureus Treated With Punicalagin, a Natural Antibiotic From Pomegranate That Disrupts Iron Homeostasis and Induces SOS
Authors: Cooper Bret , Islam Nazrul , Xu Yunfeng , Beard Hunter S. , Garrett Wesley M. , Gu Ganyu , Nou Xiangwu 
Published: March 2018

AbstractStaphylococcus aureus, a bacterial, food‐borne pathogen of humans, can contaminate raw fruits and vegetables. While physical and chemical methods are available to control S. aureus, scientists are searching for inhibitory phytochemicals from plants. One promising compound from pomegranate is punicalagin, a natural antibiotic. To get a broader understanding of the inhibitory effect of punicalagin on S. aureus growth, high‐throughput mass spectrometry and quantitative isobaric labeling was used to investigate the proteome of S. aureus after exposure to a sublethal dose of punicalagin. Nearly half of the proteins encoded by the small genome were interrogated, and nearly half of those exhibited significant changes in accumulation. Punicalagin treatment altered the accumulation of proteins and enzymes needed for iron acquisition, and it altered amounts of enzymes for glycolysis, citric acid cycling, protein biosynthesis, and purine and pyrimidine biosynthesis. Punicalagin treatment also induced an SOS cellular response to damaged DNA. Transcriptional comparison of marker genes shows that the punicalagin‐induced iron starvation and SOS responses resembles those produced by EDTA and ciprofloxacin. These results show that punicalagin adversely alters bacterial growth by disrupting iron homeostasis and that it induces SOS, possibly through DNA biosynthesis inhibition.
Alkyl‐mannoside derivatives: Glycolipids able to form big size aggregates
Authors: Sandoval‐Altamirano C. , Sanchez S.A. , Pizarro N. , Morales J. , Gunther G. 
Published: March 2018

AbstractThree different series of alkyl mannoside derivatives have been synthesized, designing the hydrophobic portion to provide different topology to the surfactant and, hence, modulating their aggregation properties. The aggregates formed were characterized using both physical and photophysical methodologies, such as surface tension, dynamic light scattering, and emission of selected fluorescent probes. The non‐ionic sugar surfactants have been widely used in studies of membrane solubilization and protein purification. Indeed, mannoside unit, nonionic and hydrophilic, can be selectively recognized by several lectins, which are proteins present in different membranes. Then, the specific interactions of these derivatives incorporated into synthetic bilayers with lectins have been studied and reported. In this work, monoalkyl derivatives with a presumably conical shape and dialkyl derivatives with cylindrical ones, including also a third family with a hydrophilic spacer were studied. These compounds are able to self‐aggregate to form micelle like structures or bilayers despite their topology. Additionally, they are able to form bilayers, using cosurfactants like cholesterol.
Diketopyrrolopyrrole‐based polymer nanowires: Control of chain conformation and nucleation
Authors: Cao Xinxiu , Chen Liang , Zhao Kefeng , Liu Jiangang , Han Yanchun 
Published: March 2018

ABSTRACTUnderstanding the nucleation process is very important in growing polymer nanowires as it plays a decisive role in determining the crystal structure and size distribution. Polymer chain conformation determines whether the polymer chains could assemble to nuclei or not. Here, chain conformation and the nucleation process were controlled to grow 3,6‐bis‐(thiophen‐2‐yl)‐N,N′‐bis(2‐decyl‐1‐tetradecyl)‐1,4‐dioxo‐pyrrolo[3,4‐c]pyrrole and thieno[3,2‐b]thiophene (DT‐PDBT‐TT) nanowires. We changed the conformation of DT‐PDBT‐TT in solution and controlled the nucleation process by using a main solvent:cosolvent system. The main solvent was a low boiling point good solvent, and the cosolvent was consisted of two high boiling point solvents with different solubility. In fact, the chain conformation in the pristine solution was changed by choosing different main solvents (with H‐bond, π–π or none interaction with the main chain) and temperatures. The absorption spectrum and TEM images showed that trichloro ethylene (TCE) was the best main solvent because it has H‐bond interaction with the polymer main chain and DT‐PDBT‐TT conformation in it approaching unimer coil conformation, which is beneficial to grow nanowires. Mixed o‐dichlorobenzene (ODCB) and anisole (AS) with different ratios were used to changing the solubility step by step to control nucleation process. Only when marginal cosolvent (ODCB:AS = 1:1) was added, could it decrease the nuclei number and avoided the aggregates simultaneously. As the main solvent evaporated slowly, the nucleation and growth happened, leading to the nanowires formation. The resulting nanowires were about 63 nm in width and one to two microns in length. The width of the DT‐PDBT‐TT structures suggests that the polymer chains are oriented along the fibril axis. Our results indicated that there are two requirements for the nanowire formation, (1) the polymer chain conformation should approach unimer coil; (2) the nucleation density should be optimized, not too much and no aggregation happened. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2018, 56, 833–841
Difficult conversations: Discussing prognosis with children with cystic fibrosis
Authors: Farber Julia Gray , Prieur Mary G. , Roach Christine , Shay Rosemary , Walter Michelle , Borowitz Drucy , Dellon Elisabeth P. 
Published: March 2018

AbstractBackground Despite the chronic, progressive, and life‐threatening nature of cystic fibrosis (CF), there are no guidelines for when and how to communicate prognosis to children with CF.MethodsSemi‐structured interviews with young adults with CF, parents of young adults with CF, and multidisciplinary CF health care providers assessed recall of and practices for communicating about prognosis. Recommendations for improvements were also solicited.ResultsYoung adults with CF recalled learning that life expectancy is limited by CF between the ages of 8 and 16 years, and that CF is a progressive disease between the ages of 7 and 19 years. They reported that the information often came from CF physicians or from online resources. Patients and parents reported earlier knowledge of prognosis than providers assumed. While learning about prognosis caused sadness and stress for some patients and families, others denied negative feelings. Interestingly, most patients reported that disclosure of prognosis had minimal impact on their adherence and treatment goals. Patients and parents reported wanting physicians to be involved in conversations about prognosis. However, providers noted several barriers to discussing prognosis, including their own reluctance, time limitations, and uncertainty about appropriate timing and content of communication.ConclusionsCommunication about prognosis is important but also difficult for providers, patients, and families. Appropriately timed conversations, using tools to facilitate communication, could ensure patients receive timely, accurate information.
Identification of an IL‐1‐induced gene expression pattern in AR+ PCa cells that mimics the molecular phenotype of AR− PCa cells
Authors: Thomas‐Jardin Shayna E. , Kanchwala Mohammed S. , Jacob Joan , Merchant Sana , Meade Rachel K. , Gahnim Nagham M. , Nawas Afshan F. , Xing Chao , Delk Nikki A. 
Published: March 2018

BackgroundIn immunosurveillance, bone‐derived immune cells infiltrate the tumor and secrete inflammatory cytokines to destroy cancer cells. However, cancer cells have evolved mechanisms to usurp inflammatory cytokines to promote tumor progression. In particular, the inflammatory cytokine, interleukin‐1 (IL‐1), is elevated in prostate cancer (PCa) patient tissue and serum, and promotes PCa bone metastasis. IL‐1 also represses androgen receptor (AR) accumulation and activity in PCa cells, yet the cells remain viable and tumorigenic; suggesting that IL‐1 may also contribute to AR‐targeted therapy resistance. Furthermore, IL‐1 and AR protein levels negatively correlate in PCa tumor cells. Taken together, we hypothesize that IL‐1 reprograms AR positive (AR+) PCa cells into AR negative (AR−) PCa cells that co‐opt IL‐1 signaling to ensure AR‐independent survival and tumor progression in the inflammatory tumor microenvironment.MethodsLNCaP and PC3 PCa cells were treated with IL‐1β or HS‐5 bone marrow stromal cell (BMSC) conditioned medium and analyzed by RNA sequencing and RT‐QPCR. To verify genes identified by RNA sequencing, LNCaP, MDA‐PCa‐2b, PC3, and DU145 PCa cell lines were treated with the IL‐1 family members, IL‐1α or IL‐1β, or exposed to HS‐5 BMSC in the presence or absence of Interleukin‐1 Receptor Antagonist (IL‐1RA). Treated cells were analyzed by western blot and/or RT‐QPCR.ResultsComparative analysis of sequencing data from the AR+ LNCaP PCa cell line versus the AR− PC3 PCa cell line reveals an IL‐1‐conferred gene suite in LNCaP cells that is constitutive in PC3 cells. Bioinformatics analysis of the IL‐1 regulated gene suite revealed that inflammatory and immune response pathways are primarily elicited; likely facilitating PCa cell survival and tumorigenicity in an inflammatory tumor microenvironment.ConclusionsOur data supports that IL‐1 reprograms AR+ PCa cells to mimic AR− PCa gene expression patterns that favor AR‐targeted treatment resistance and cell survival.
Comparison of demographic fitness and biocontrol effectiveness of two parasitoids, Encarsia sophia and Eretmocerus hayati (Hymenoptera: Aphelinidae), against Bemisia tabaci (Hemiptera: Aleyrodidae)
Authors: Xu Hai‐Yun , Yang Nian‐Wan , Chi Hsin , Ren Guo‐Dong , Wan Fang‐Hao 
Published: March 2018

AbstractBACKGROUNDThe autoparasitoid Encarsia sophia and the primary parasitoid Eretmocerus hayati are two important parasitoids used against the whitefly Bemisia tabaci, with different reproductive strategies. To incorporate these two parasitoids into a sustainable whitefly control program, it is necessary to evaluate and compare their fitness and biocontrol effectiveness under identical experimental conditions. The demographic characteristics, parasitism rate and host‐feeding rate of En. sophia and Er. hayati were analyzed using an age‐stage, two‐sex life table and the CONSUME‐MSChart computer program.RESULTSThe mean fecundity of Er. hayati (211.4 offspring per female) was significantly higher than that of En. sophia (101.6 offspring per female), although the oviposition days of En. sophia was longer than that of Er. hayati. No significant difference was found in the intrinsic rate of increase (r), finite rate of increase (λ) or net reproduction rate (R0) between the two parasitoid species, but the mean generation time (T) of En. sophia (18.8 days) was significantly shorter than that of Er. hayati (20.5 days). The net host feeding rate (C0) of En. sophia was 84.1 whiteflies per individual, significantly higher than the 17.6 whiteflies per individual consumed by Er. hayati. The finite killing rate (ν) of En. sophia (0.6713) for whitefly was significantly greater than that produced by Er. hayati (0.3652).CONCLUSIONThe En. sophia population can increase faster and have a higher killing potential than the Er. hayati population. Taking both the demographic fitness and killing potential of the two parasitoids into consideration, En. sophia would be the preferred choice to release in a biological control program. © 2018 Society of Chemical Industry
Ambient levels of PFOS and PFOA in multiple environmental media
Authors: Vedagiri Usha K. , Anderson Richard H. , Loso Heather M. , Schwach Catherine M. 
Published: March 2018

AbstractMaking remediation and risk management decisions for widely‐distributed chemicals is a challenging aspect of contaminated site management. The objective of this study is to present an initial evaluation of the ubiquitous, ambient environmental distribution of poly‐ and perfluoroalkyl substances (PFAS) within the context of environmental decision‐making at contaminated sites. PFAS are anthropogenic contaminants of emerging concern with a wide variety of consumer and industrial sources and uses that result in multiple exposure routes for humans. The combination of widespread prevalence and low screening levels introduces considerable uncertainty and potential costs in the environmental management of PFAS.PFAS are not naturally‐occurring, but are frequently detected in environmental media independent of site‐specific (i.e., point source) contamination. Information was collected on background and ambient levels of two predominant PFAS, perfluorooctane sulfonate and perfluorooctanoate, in North America in both abiotic media (soil, sediment, surface water, and public drinking water supplies) and selected biotic media (human tissues, fish, and shellfish). The background or ambient information was compiled from multiple published sources, organized by medium and concentration ranges, and evaluated for geographical trends and, when available, also compared to health‐based screening levels. Data coverage and quality varied from wide‐ranging and well‐documented for soil, surface water, and serum data to more localized and less well‐documented for sediment and fish and shellfish tissues and some uncertainties in the data were noted. Widespread ambient soil and sediment concentrations were noted but were well below human health‐protective thresholds for direct contact exposures. Surface water, drinking water supply waters (representing a combination of groundwater and surface water), fish and shellfish tissue, and human serum levels ranged from less than to greater than available health‐based threshold values. This evaluation highlights the need for incorporating literature‐based or site‐specific background into PFAS site evaluation and decision‐making, so that source identification, risk management, and remediation goals are properly focused and to also inform general policy development for PFAS management.
Ultrathin TiO2 Coating on LiCoO2 for Improved Electrochemical Performance as Li–Ion Battery Cathode
Authors: Jayasree Silpasree S. , Nair Shantikumar , Santhanagopalan Dhamodaran 
Published: March 2018

AbstractSurface modification of LiCoO2 (LCO) gained much attention as it could play a prominent role in improving electrochemical performance and structural stability. Herein, we report an ultra‐thin TiO2 coating on LiCoO2 (LCO‐TiO2) as a potential candidate to overcome the electrochemical, structural instability and interface issues of the bare‐LCO. The structural properties as well as electrochemical performances of bare‐LCO and LCO‐TiO2 were investigated by X‐Ray diffraction, Transmission Electron Microscopy (TEM), X‐ray Photoelectron Spectroscopy (XPS), Galvanostatic charge‐discharge and electrochemical impedance spectroscopy (EIS). At the end of 100 cycles, 1C rate capacity retention was about 50% and 90% for bare‐LCO and LCO‐TiO2 respectively. Rate studies showed that the bare LCO exhibited a specific capacity of ∼120 mAh/g and only 16 mAh/g at 1C and 60 discharge rates respectively whereas, the TiO2 coated LCO showed a capacity of ∼132 mAh/g and nearly 98 mAh/g at 1C and 60C discharge rates respectively. The implementation of TiO2 coating over LiCoO2 enhanced the electrochemical performance, cell stability as well as efficiency.
Constructing Multifunctional Heterostructure of Fe2O3@Ni3Se4 Nanotubes
Authors: Zheng Penglun , Zhang Yu , Dai Zhengfei , Zheng Yun , Dinh Khang Ngoc , Yang Jun , Dangol Raksha , Liu Xiaobo , Yan Qingyu 
Published: March 2018

AbstractHeterostructures have attracted increasing attention due to their amazing synergetic effects, which may improve the electrochemical properties, such as good electrical/ionic conductivity, electrochemical activity, and mechanical stability. Herein, novel hierarchical Fe2O3@Ni3Se4 nanotubes are successfully fabricated by a multistep strategy. The nanotubes show length sizes of ≈250–500 nm, diameter sizes of ≈100–150 nm, and wall thicknesses of ≈10 nm. The as‐prepared Fe2O3@Ni3Se4 nanotubes with INi:Fe = 1:10 show excellent Li storage properties (897 mAh g−1 high reversible charge capacity at 0.1 A g−1), good rate performance (440 mAh g−1 at 5 A g−1), and outstanding long‐term cycling performance (440 mAh g−1 at 5 A g−1 during the 300th cycle) as an anode material for lithium ion batteries. In addition, the Fe2O3@Ni3Se4 nanotubes with INi:Fe = 1:10 (the atomic ratio between Ni and Fe) show superior electrocatalytic performance toward the oxygen evolution reaction with an overpotential of only 246 mV at 10 mA cm−2 and a low Tafel slope of 51 mV dec−1 in 1 m KOH solution.
Determination of profens in pharmaceuticals by heart‐cut achiral‐chiral two‐dimensional HPLC
Authors: Peñín‐Ibáñez Miguel , Santos‐Delgado María Jesús , Polo‐Diez Luís María 
Published: March 2018

AbstractProfens are important non‐steroidal anti‐inflammatory pharmaceutical drugs and their behavior depends on their enantiomeric form. Three of the most employed profens, ketoprofen, naproxen and ibuprofen, were separated simultaneously in pairs by two‐dimensional achiral‐chiral high‐performance liquid chromatography using heart‐cut mode. The total amount of each profen was determined using a C8 column in the first achiral system; in the second chiral system, the enantiomeric fraction of each profen was determined using an α1‐acid glycoprotein column. Mobile phases were optimized by factorial design, response surfaces and multi‐response analysis paying particular attention to mobile phase compatibility of both columns and to transferring time between systems. The effect of temperature on each profen and their enantiomer retention was studied, the thermodynamic parameters being calculated. Calibration graphs were linear in the ranges of 2–20, 0.5–10 and 10–40 mg/L for ketoprofen, naproxen and ibuprofen respectively in both systems. The method allowed the analysis of three pharmaceuticals establishing the enantiomeric fraction of each profen using a simple sample preparation; moreover, the first achiral system cleans the sample deeply preventing deterioration of the expensive chiral column. Recoveries over 80% and the enantiomeric fraction of each profen were obtained allowing determination of the pharmaceutical purity.