bluuebunny/crossref_metadata_2025_split huggingface dataset:
IROND-L: study protocol for a French prospective, quasi-experimental, multicentre trial to examine the impact of a coordinated multidisciplinary approach for women victims of violence
Authors: El-Khoury Fabienne , Ben Ghezala Inès , Hatem Ghada , Jaffal Zohra , Soares Andre , Yacini Leila , Duchesne Sophie , Dommergues Marc , Bretelle Florence , Eudeline Sara , Hoffmann Pascale , Masse-Navette Claire , Layachi Fanida , Maurice Odile , de Foucher de Careil Tiphaine , Bardou Marc 
Published: November 2024

Background and objectivesViolence against women (VAW) is widespread and can have serious physical and mental health consequences, including post-traumatic stress disorder (PTSD) and sleep disorders. Victim-survivors often face barriers in accessing specialised care, highlighting the need for a multidisciplinary response, especially in healthcare settings. The Maison des Femmes (MdF) model provides holistic support to women experiencing VAW, including medical, psychological, social and legal support. The aim of this study is to examine whether the MdF’s comprehensive intervention programme offers advantages over standard care in improving mental health indicators, such as PTSD.Method and analysisOur pragmatic quasi-experimental study uses a non-randomised controlled cluster design. The intervention group comprises women enrolled in MdFs in five French cities, while the comparison group includes women receiving usual care in sociomedical structures located geographically close to MdF centres. Our study aims to recruit 360 women (180 per group), aged 18 years or older, who have experienced intimate partner violence or sexual violence and who seek care at the study centres. The primary analysis will compare the change in PTSD Checklist for DSM-5 (PCL-5) scores over 6 months in the two groups using multivariable linear regression with propensity score adjustment. Secondary outcomes include sleep disorders, quality of life, symptoms of anxiety and depression, self-esteem, sense of safety and well-being, initiation of legal and socioprofessional proceedings, and healthcare utilisation.Ethics and disseminationThe study was approved by the ‘Comité de protection des personnes Ile de France III’ (CPP Committee for the Protection of Persons Ile de France III; institutional review board on 20 December 2023; Ref no. (Numéro SI): 23.04197.000491).The results of the study will be communicated via academic publications; easily understandable briefs for a broader public; and proactive involvement with medical institutions, journalists and advocacy groups.Trial registration numberNCT06226818. Version Number 1- february2024.
Longitudinal changes in lifestyle behaviours and cardiovascular health during the transition to fatherhood: the Dad Bod observational cohort study protocol
Authors: Landry Matthew J , Pineda Jocelyn P , Lee Jaylen M , Hoyt Michael A , Edwards Karen L , Lindsay Karen L , Gardner Christopher D , Wong Nathan D 
Published: November 2024

IntroductionDespite the importance of the transition to fatherhood as a critical life stage among young adult men, much remains unknown about the factors predictive of ideal cardiovascular health (CVH) and how CVH is impacted as young men face new roles and responsibilities associated with fatherhood.Methods and analysisTo address this gap, the Dad Bod Study is a prospective, longitudinal and observational study designed to examine how fatherhood affects young men’s CVH. A total of 125, first-time prospective fathers (men, 19–39 years) will be enrolled and followed over 1.5 years. Metrics of the American Heart Association’s ‘Life’s Essential 8’ as well as demographic, social and psychosocial factors will be collected at four time points (baseline (during the pregnant partner’s second trimester), 1-month post partum, 6 months post partum and 1 year post partum). The primary aims are to measure predictors of CVH among first-time fathers and describe longitudinal changes in CVH. A secondary aim is to identify the best practices for recruitment, retention and remote data collection in this population.Ethics and disseminationThe study was approved by the University of California, Irvine Institutional Review Board (IRB #4907, approved 1 May 2024). Participants will provide written consent. Study data will be disseminated in manuscripts submitted to peer-reviewed journals as well as in abstracts submitted to conferences and in the resulting posters and presentations. After study completion, anonymised data and material will be made publicly available.
Nemvaleukin alfa, a modified interleukin-2 cytokine, as monotherapy and with pembrolizumab in patients with advanced solid tumors (ARTISTRY-1)
Authors: Vaishampayan Ulka N , Muzaffar Jameel , Winer Ira , Rosen Seth D , Hoimes Christoper J , Chauhan Aman , Spreafico Anna , Lewis Karl D , Bruno Debora S , Dumas Olivier , McDermott David F , Strauss James F , Chu Quincy S , Gilbert Lucy , Chaudhry Arvind , Calvo Emiliano , Dalal Rita , Boni Valentina , Ernstoff Marc S , Velcheti Vamsidhar 
Published: November 2024

BackgroundNemvaleukin alfa (nemvaleukin, ALKS 4230) is a novel, engineered cytokine that selectively binds to the intermediate-affinity interleukin-2 receptor, preferentially activating CD8+T cells and natural killer cells, with minimal expansion of regulatory T cells, thereby mitigating the risk of toxicities associated with high-affinity interleukin-2 receptor activation. Clinical outcomes with nemvaleukin are unknown. ARTISTRY-1 investigated the safety, recommended phase 2 dose (RP2D), and antitumor activity of nemvaleukin in patients with advanced solid tumors.MethodsThis was a three-part, open-label, phase 1/2 study: part A, dose-escalation monotherapy, part B, dose-expansion monotherapy, and part C, combination therapy with pembrolizumab. The study was conducted at 32 sites in 7 countries. Adult patients with advanced solid tumors were enrolled and received intravenous nemvaleukin once daily on days 1–5 (21-day cycle) at 0.1–10 µg/kg/day (part A), or at the RP2D (part B), or with pembrolizumab (part C). Primary endpoints were RP2D selection and dose-limiting toxicities (part A), and overall response rate (ORR) and safety (parts B and C).ResultsFrom July 2016 to March 2023, 243 patients were enrolled and treated (46, 74, and 166 in parts A, B, and C, respectively). The maximum tolerated dose was not reached. RP2D was determined as 6 µg/kg/day. ORR with nemvaleukin monotherapy was 10% (7/68; 95% CI 4 to 20), with seven partial responses (melanoma, n=4; renal cell carcinoma, n=3). Robust CD8+T and natural killer cell expansion, and minimal regulatory T cell expansion were observed following nemvaleukin treatment. ORR with nemvaleukin plus pembrolizumab was 13% (19/144; 95% CI 8 to 20), with 5 complete and 14 partial responses; 6 responses were in PD-(L)1 inhibitor-approved and five in PD-(L)1 inhibitor-unapproved tumor types. Three responses were in patients with platinum-resistant ovarian cancer. The most common grade 3–4 treatment-related adverse events (TRAEs) in parts B and C, respectively, were neutropenia (49%, 21%) and anemia (10%, 11%); 4% of patients in each part discontinued due to TRAEs.ConclusionsNemvaleukin was well tolerated and demonstrated promising antitumor activity across heavily pretreated advanced solid tumors. Phase 2/3 studies of nemvaleukin are ongoing.Trial registration numberNCT02799095.
Development of a novel ‘In-Water Mass Casualty Triage Tool’
Authors: Barton Colin A , Morgan P , Tipton MJ 
Published: November 2024

The number of in-water mass casualty incidents has increased in recent years and provides significant challenges to rescuers. Existing triage systems require the rescue of immersed (in water) casualties before triage is undertaken. A tool that enables triage to be undertakenbeforerescue, and therefore the prioritisation of that rescue, should improve the efficiency, efficacy and survival rate associated with the management of such incidents.In this paper, we describe the rationale and development of a proposed novel ‘in-water mass casualty triage tool (IWMCTT)’ to assist in the swift and effective triage of those in the water in mass casualty situationsbeforethey are rescued, based upon the likelihood of survivalafterimmersion. The tool is based on a review of the literature related to the hazards associated with immersion, most notably drowning.The IWMCTT employs a sequential approach to streamline the identification and prioritisation for rescue of immersed individuals; it considers factors such as hazards, visibility constraints, purposeful swimming, moving or floating, airway position, availability of flotation assistance and flotation device effectiveness. It categorises casualties from W1 (high) to W4 (low) priority for rescue.The proposed IWMCTT offers a potential solution to some of the challenges faced during water-based mass casualty incidents; providing rescue assets (rigid-hulled, inflatable boats, ships and helicopters) with a rapid and effective approach to assess and prioritise individuals for rescue and medical attention, hopefully thereby reducing mortality and morbidity. The IWMCTT requires further evaluation and validation.
Evaluation of Ferula assa-foetida L. accessions under different temperature regimes to overcome seed dormancy and different media mixtures to promote seedling growth
Authors: Kumar Ravi , Rana Amit , Katoch Ajeta , Singh Satbeer , Sharma Sahil , Singh Sanatsujat , Kumar Ashok 
Published: November 2024

Ferula assa-foetida L., a perennial crop of the Apiaceae family, has internal physical seed dormancy that inhibits its germination ability. Hence, to improve germination capacity and overcome seed dormancy, the present study was conducted using six accessions for assessing seed viability using 1% Tetrazolium test three times every 6 months and grown under three different temperature treatments (5, 15, and 25 °C) during 2018–19 and 2019–20. These accessions were also grown under six different potting mixtures to optimize the best media for its survivability under field conditions. Results from the tetrazolium test indicated an average seed viability of 73.03% and showed an ∼5% reduction during 2018–20. From germination tests, a chilling treatment of 5 °C was found most effective for breaking dormancy. Besides, the seedlings grown under different potting mixtures showed that media mixtures in the combination of soil, sand, farmyard manure, and cocopeat were most appropriate for better germination stand. However, further studies are required to explain the agro-practices to cultivate this endangered plant at field capacity. It was also observed that genotypes EC966538 and EC968470 were best performers for overall germination as well as seedling survival parameters and could be used as base populations in future selection and improvement breeding programs.
Optimization of technology processes for enhanced CMOS-integrated 1T-1R RRAM device performance
Authors: Dorai Swamy Reddy Keerthi , Pérez Eduardo , Baroni Andrea , Mahadevaiah Mamathamba Kalishettyhalli , Marschmeyer Steffen , Fraschke Mirko , Lisker Marco , Wenger Christian , Mai Andreas 
Published: November 2024

Abstract
Implementing artificial synapses that emulate the synaptic behavior observed in the brain is one of the most critical requirements for neuromorphic computing. Resistive random-access memories (RRAM) have been proposed as a candidate for artificial synaptic devices. For this applicability, RRAM device performance depends on the technology used to fabricate the metal–insulator–metal (MIM) stack and the technology chosen for the selector device. To analyze these dependencies, the integrated RRAM devices in a 4k-bit array are studied on a 200 mm wafer scale in this work. The RRAM devices are integrated into two different CMOS transistor technologies of IHP, namely 250 nm and 130 nm and the devices are compared in terms of their pristine state current. The devices in 130 nm technology have shown lower number of high pristine state current devices per die in comparison to the 250 nm technology. For the 130 nm technology, the forming voltage is reduced due to the decrease of $$\hbox {HfO}_2$$

HfO
2

dielectric thickness from 8 nm to 5 nm. Additionally, 5% Al-doped 4 nm $$\hbox {HfO}_2$$

HfO
2

dielectric displayed a similar reduction in forming voltage and a lower variation in the values. Finally, the multi-level switching between the dielectric layers in 250 nm and 130 nm technologies are compared, where 130 nm showed a more significant number of conductance levels of seven compared to only four levels observed in 250 nm technology.

Graphical abstract
The Monument experiment: ordinary muon capture studies for $$0\nu \beta \beta $$ decay
Authors: Araujo G. R. , Bajpai D. , Baudis L. , Belov V. , Bossio E. , Cocolios T. E. , Ejiri H. , Fomina M. , Gusev K. , Hashim I. H. , Heines M. , Kazartsev S. , Knecht A. , Mondragón E. , Ng Z. W. , Ostrovskiy I. , Othman F. , Rumyantseva N. , Schönert S. , Schwarz M. , Shevchik E. , Shirchenko M. , Shitov Yu , Sushenok E. O. , Suhonen J. , Vogiatzi S. M. , Wiesinger C. , Zhitnikov I. , Zinatulina D. 
Published: November 2024

AbstractThe Monument experiment measures ordinary muon capture (OMC) on isotopes relevant for neutrinoless double-beta ($$0\nu \beta \beta $$

0
ν
β
β

) decay and nuclear astrophysics. OMC is a particularly attractive tool for improving the theoretical description of $$0\nu \beta \beta $$

0
ν
β
β

decay. It involves similar momentum transfers and allows testing the virtual transitions involved in $$0\nu \beta \beta $$

0
ν
β
β

decay against experimental data. During the 2021 campaign, Monument studied OMC on $$^{76}$$

76

Se and $$^{136}$$

136

Ba, the isotopes relevant for next-generation $$0\nu \beta \beta $$

0
ν
β
β

decay searches, like Legend and nEXO. The experimental setup has been designed to accurately extract the total and partial muon capture rates, which requires precise reconstruction of energies and time-dependent intensities of the OMC-related $$\gamma $$
γ
rays. The setup also includes a veto counter system to allow selecting a clean sample of OMC events. This work provides a detailed description of the Monument setup operated during the 2021 campaign, its two DAQ systems, calibration and analysis approaches, and summarises the achieved detector performance. Future improvements are also discussed.
Top quark decays in the flavor-dependent $$U(1)_X$$ model
Authors: Ge Zhao-feng , Yang Jin-lei 
Published: November 2024

AbstractThe branching ratios of the flavor changing top quark decays in the SM are too small to be detected experimentally. Therefore, any observable signal for these processes at the LHC would serve as compelling evidence for new physics. In the flavor-dependent $$U(1)_X$$

U

(
1
)

X

model, a newly introduced Higgs singlet interacts directly with the quark sector and mixes with the SM-like Higgs, influencing the $$t\rightarrow ch$$

t
→
c
h

and $$t\rightarrow uh$$

t
→
u
h

process. Additionally, the flavor dependence of the $$U(1)_X$$

U

(
1
)

X

charge affect the $$t\rightarrow cZ$$

t
→
c
Z

process. In this work, we investigate these process within the framework of the flavor-dependent $$U(1)_X$$

U

(
1
)

X

model. Numerical results indicates that with suitable choices of new physics parameters, the branching ratios of these processes in the flavor-dependent $$U(1)_X$$

U

(
1
)

X

model can be significantly enhanced. Specifically, the branching ratios of $$t\rightarrow ch$$

t
→
c
h

and $$t\rightarrow uh$$

t
→
u
h

can reach the order of $$10^{-4}$$

10

-
4

in some chosen parameter spaces, which is close to the current experimental upper limit. This suggests that these processes have significant opportunities to be observed experimentally, and the parameter space of the model will face constraints from the experimental upper bounds.
Exploring thermodynamics inconsistencies in unimodular gravity: a comparative study of two energy diffusion functions
Authors: Cruz Miguel , Cruz Norman , Lepe Samuel 
Published: November 2024

AbstractIn this work we study the thermodynamics formulation for unimodular gravity under the election of two different models for the energy diffusion function. Such function encodes the current for the non-conservation of the energy-momentum tensor and is usually termed as Q(t). In analogy to the cosmological scenario where the cosmic expansion is influenced by Q(t), the thermodynamics implications in this scheme are also determined by the choice of the function Q(t), as we discuss in the work. Specifically, we consider the barotropic and the continuous spontaneous localization models as energy diffusion functions, commonly used in the literature as viable candidates to face the well-known $$H_{0}$$

H
0

tension. The consistency conditions demanded for the entropy of the system in terms of the cosmological parameters of the model: positive production ($$dS/dt>0$$

d
S
/
d
t
>
0

) and convexity condition ($$d^{2}S/dt^{2} <0$$

d
2

S
/
d

t
2

<
0

), are investigated. We show that these conditions strongly constraint the viability of both models. Additionally, we comment about our results and compare with those obtained in recent works where the restriction of the parameters for these two diffusion models was implemented with the use of cosmological data.
Imprints of the Einasto density profile and complexity factor on traversable wormholes in f(R, T) theory
Authors: Naseer Tayyab , Sharif M. , Faiza Mona , Dayanandan Baiju 
Published: November 2024

AbstractThe focus of this work is centered on determining whether traversable wormholes admitting Einasto density profile exist within the framework of f(R, T) gravity. Using the Morris–Thorne spacetime, we express the wormhole configuration and formulate the anisotropic gravitational equations for a particular linear modified model. Afterwards, by considering two different (constant and variable) redshift functions, we derive the shape function for wormholes and examine its potential stability. The developed functions conform to the necessary conditions and form a connection between two spacetime regions that are asymptotically flat. We also examine the viability of resulting wormhole solutions by verifying their violation with the null energy conditions. We also investigate the active gravitational mass and the complexity factor for our solutions. The later quantity is found to be negative near the wormhole throat and becomes zero when moving away from this point. Further, various methods of stability analysis are utilized to assess the developed models. Our results suggest that the constructed wormhole geometries meet the necessary conditions, thereby existing within the considered modified gravity.
Graveyard Symphony; A Study Investigating the Effectiveness of a Prototype Music Game
Authors: Brett Jack , Gatzidis Christos , Davis Tom 
Published: November 2024

Learning to play a musical instrument, particularly the keyboard, can be challenging for adults who are beginners or have previously given up due to a lack of foundational skills and engaging practice methods. To address this issue, we have developed prototype games aimed at honing specific musical skills. Through several pilot studies, it became evident that assessing the effectiveness of video game experiences in skill acquisition compared to traditional practice methods was essential. Therefore, we hypothesised that video games could encourage sustained practice and reduce dropout rates among beginners. Consequently, our focus shifted to creating games centred on sheet music reading, specifically matching musical staff positions to keyboard keys.
This article presents a study aimed at evaluating the effectiveness of a specific prototype game in enhancing musical notation reading skills. Additionally, we assessed the game’s engagement, educational value and usability in comparison to a conventional practice tool. The results indicated that the game was equally or potentially more effective than the practice tool in improving the targeted skill. Furthermore, participants perceived the practice game as having greater educational value, although it did not surpass the practice tool in terms of engagement. Further discussion is provided to elucidate the reasons behind this finding.
Neural network embedding of functional microconnectome
Authors: Shirakami Arata , Hase Takeshi , Yamaguchi Yuki , Shimono Masanori 
Published: November 2024

Abstract
Our brains operate as a complex network of interconnected neurons. To gain a deeper understanding of this network architecture, it is essential to extract simple rules from its intricate structure. This study aimed to compress and simplify the architecture, with a particular focus on interpreting patterns of functional connectivity in 2.5 hr of electrical activity from a vast number of neurons in acutely sliced mouse brains. Here, we combined two distinct methods together: automatic compression and network analysis. Firstly, for automatic compression, we trained an artificial neural network named NNE (neural network embedding). This allowed us to reduce the connectivity to features, be represented only by 13% of the original neuron count. Secondly, to decipher the topology, we concentrated on the variability among the compressed features and compared them with 15 distinct network metrics. Specifically, we introduced new metrics that had not previously existed, termed as indirect-adjacent degree and neighbor hub ratio. Our results conclusively demonstrated that these new metrics could better explain approximately 40%–45% of the features. This finding highlighted the critical role of NNE in facilitating the development of innovative metrics, because some of the features extracted by NNE were not captured by the currently existed network metrics.
Hasidism in the Urban Fabric: Is There a “Hasidic Architecture”?
Authors: Levin Vladimir 
Published: November 2024

Abstract
This article discusses the question of whether or not a specific Hasidic architecture emerged in Eastern and East-Central Europe from the late eighteenth to the mid-twentieth century. It deals with the architecture of the courts of Hasidic masters, paying special attention to kloyzn, residences, the new types of courts that emerged in big cities, and the symbolic usage of the images of court kloyzn as identification markers by contemporary Hasidic groups. The article also discusses the ohalim on the graves of the tzaddikim and regular Hasidic synagogues. The main conclusion is that Hasidim did not develop a specific architectural language that defined their places of worship: the Hasidic nature of a synagogue was a function of the worshippers’ behavior, not its architectural features, spatial configuration, or urban location.
Training the Philosopher King: Ancient Models of Political Action in Hannah Arendt and Michel Foucault
Authors: Tilleczek William 
Published: November 2024

Abstract
This article offers a comparative study of Hannah Arendt’s and Michel Foucault’s “returns” to classical antiquity. I focus on their overlapping readings of Socrates as a “civilization trainer” and their divergent readings of Plato – who is for Foucault a trainer of kings and for Arendt a utopian engineer – to argue that both Arendt and Foucault draw from Greek antiquity a substantively underdetermined but politically choice worthy form of action: a courageous and critical relation to the present moment in which one lives, consisting of the public and philosophical critique of what we are thinking and doing. Without falling into nostalgic narratives about lost golden ages, they nonetheless retrieve Socratic ethical exemplarity for a (post)modern political theory that has lost interest in the game of building perfect regimes. I conclude by exploring the differences and overlaps in Foucault’s and Arendt’s vision of what is needed to revitalize political action today.