bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paul Hermann’s Ceylon Herbarium (1672–1679) at Leiden, the Netherlands
Authors: van Andel Tinde , Barth Nadine 
Published: October 2018

AbstractThe German physician and botanist Paul Hermann (1646–1695), considered as one of the pioneers of Asian Botany, collected the first plant specimens in the Dutch colony of Ceylon (now Sri Lanka) in the 1670s. Hermann’s collections were bound in several book herbaria, some of which formed the basis of influential 18th century publications: Linnaeus’sFlora ZeylanicaandSpecies plantarumand Burmann’sThesaurus Zeylanicus. Two of Hermann’s book herbaria, currently kept by Naturalis Biodiversity Center at Leiden, the Netherlands, remained largely unnoticed. Our aim was to identify all specimens of the Leiden Hermann collection, translate his handwritten Latin notes, and analyse both the scientific importance and societal relevance of this historic herbarium. By publishing the entire Leiden Hermann herbarium online, we intend to make this valuable botanical treasure available to the public for the first time in 339 years. The Leiden Hermann herbarium contains 183 specimens, belonging to 157 species (61 families). Striking aspects are the 15 cinnamon specimens, reflecting the interest in the spice trade of Hermann’s employer, the Dutch East Indian Company. Four specimens are probably collected by Rumphius in the Moluccas and 49 species are lacking from Hermann’s other book herbaria kept at London, Paris and Erfurt. Although there are no Linnaean type specimens present in the Leiden volumes, these specimens did form the basis of Hermann’s drawings, species descriptions and notes on local names and plant uses that were published after his death. For 130 specimens, one or more of Hermann’s 17th century Sinhala names are still used in Sri Lanka, although differently spelled and sometimes only partly conserved. Most of the plant uses written on the vouchers or later published in theMusaeum Zeylanicumare still practiced in southern Asia. The manufacturing of gunpowder from charcoal, substitutes for betel chewing and several ritual uses, however, seem to have gone lost or remained undocumented. The Leiden Hermann collection reflects the Dutch colonial quest for valuable spices, materials and medicines, and offers opportunities for ethnobotanical and linguistic research on changes in Sri Lankan plant names and uses over the past centuries. This historic herbarium is also relevant for validating claims on culturally important plant use by Sri Lankan citizens, whose ancestors shared their knowledge and enabled the making of science in the late 17th century.
CONSTRUÇÕES COM O VERBO PASSAR: MUDANÇA CONSTRUCIONAL EM PERSPECTIVA FUNCIONAL
Authors: Jordão Geisa Maria Jayme 
Published: October 2018

Este artigo apresenta os resultados obtidos em nossa Tese, sob a perspectiva da Linguística Funcional, que investigou as construções formadas com o verbo passar pleno, aquele que seleciona argumentos, ex: “... eu passei na roleta do ônibus...” (D&G) e sua migração para passar auxiliar, aquele que acompanha um verbo pleno, constituindo as construções perifrásticas que marcam aspecto inceptivo, ex: “– Como o caso foi levado à Corte, passei a coletar todo tipo de cone...” (RG). Com o intuito de investigar as relações sintático-semânticas das construções com passar, foram determinados quatro subesquemas de análise, sendo três para as construções com passar pleno, nos quais analisamos 314 construções, e um subesquema para as construções perifrásticas com passar auxiliar, em um total de 80 casos. Assim nossos corpora totalizam 394 construções com passar. Visando a uma análise diacrônica, pesquisamos textos dos séculos XVIII, XIX, XX e XXI, nas seguintes fontes: Corpus Discurso e Gramática (D&G), Corpora do Projeto Para a História do Português Brasileiro (PHPB), Corpus do Português (CP), Programa Roda Viva (RV) e Revista O Globo (RG). Os corpora foram constituídos por registros da oralidade (D&G) e escritos (PHPB, CP, RG, RV), nos gêneros: entrevistas, cartas e artigos, todos apresentando sequências narrativas. Os dados foram analisados, a partir de grupos de fatores correspondentes aos subesquemas sintático-semânticos, com o objetivo de acompanhar o pareamento forma ßà função das construções com passar.
„Racjonalne usprawnienie” w ramach edukacji dzieci i młodzieży z niepełnosprawnością – rozważania na kanwie konwencji o prawach osób niepełnosprawnych Część 2
Authors: Mikrut Adam 
Published: October 2018

The authorities of the Republic of Poland have ratified the Convention on the Rights of Persons with Disabilities and have undertaken the responsibility to implement such changes in the internal law and in social policy which aim at ensuring full and equal enjoyment of all rights and freedoms by people with disabilities and preventing their discrimination in different aspects of life. One of the ways of fulfilling this commitment is described as ‘reasonable accommodation’. The author of this article has attempted to find manifestations of such activities in the field of school legislation and its practical examples. As a result, it turned out that in the analysed area many solutions are in line with the spirit of the ‘reasonable accommodation’.
Analiza wypowiedzi pracowników domów opieki społecznej na temat ich własnego sposobu rozumienia i doświadczania dorosłości przez podopiecznych
Authors: Myśliwczyk Iwona 
Published: October 2018

Experiencing institutions by adults with mental retardation still evokes controversy in literature. The study presents the results of the research on the analysis of narratives by long-term care centre workers. The reality they experienced revealed ‘subjective truth’ about adult lives of mentally retarded people. The analysis of the narratives showed both the personnel’s work which can support, initiate and create adult lives in institution and work which can impair people’s functioning to such an extent that they become passive, withdrawn and isolated. More often mentally retarded adults in institutions experience limitations which affect their lives and create them according to a particular pattern. The lives of adults with mental retardation depend on personnel’s approach and attitude towards a group.
Wykorzystanie nowych technologii w orientacji przestrzennej osób z niepełnosprawnością wzroku
Authors: Miler-Zdanowska Kamila 
Published: October 2018

The fast development of electronic and information technologies makes them becoming ever more present in the lives of the blind and visually impaired people. The aim of this article is to present modes of mobility of people with visual impairment, with particular focus on new technologies. The article contains the classification and characteristics of electronic aids used in spatial orientation and mobility for blind people. It also presents the benefits and difficulties of using these types of new technologies. The article presents research projects related to the construction and testing of new technical solutions in Poland.
Stres rodzicielski matek dzieci z autyzmem
Authors: Banasiak Anna 
Published: October 2018

The aim of the research presented in this article was to determine the level of parental stress among mothers of autistic children. Thirty-nine mothers of autistic children, forty mothers of children with Down syndrome as well as forty mothers of children with developing normally took part in the study. We used the Questionnaire on Resources and Stress (QRS, designed by J. Holroyd) to assess the parental stress among families of developmentally delayed children or children with intellectual disabilities. The results of the study indicate that, comparing to mothers of children with Down syndrome and mothers of children developing well, mothers of autistic children are the ones who experience the highest level of parental stress. Potential sources of coping strategies among mothers of children that suffer from autism are associated with relatively low stress levels as a result of disharmony within the family, personal issues, the child’s health situation and financial problems.
On the femtosecond laser-induced photochemistry in silver-containing oxide glasses: mechanisms, related optical and physico-chemical properties, and technological applications
Authors: Petit Yannick , Danto Sylvain , Guérineau Théo , Abou Khalil Alain , Le Camus Arthur , Fargin Evelyne , Duchateau Guillaume , Bérubé Jean-Philippe , Vallée Réal , Messaddeq Younès , Cardinal Thierry , Canioni Lionel 
Published: October 2018

AbstractLaser-induced glass processing has led to huge progress and applications over the last two decades. Here, we review recent advances in femtosecond laser-induced photochemistry in isotropic transparent oxide glasses specifically tailored with silver photoactive agents. The understanding of the influence of the considered glass matrix on the nature and properties of the created silver species is of prime importance. After presenting the key material properties, the formation mechanisms of laser-induced silver-based species are discussed, and potential technological applications are highlighted. Laser-induced processing of silver-containing oxide glasses paved the way for the fabrication of complex integrated waveguides and optical circuits with innovative fluorescent, nonlinear optical, and plasmonic properties. The universality of the method is expected to extend in any glass material that shows a similar laser-induced behavior in terms of silver cluster production.
Urodynamics and diagnosis of urinary incontinence
Authors: Stangel-Wójcikiewicz Klaudia , Migdał Małgorzata , Skotniczny Krzysztof , Hessel Tadeusz , Chłosta Piotr 
Published: October 2018

Abstract
The urinary incontinence diagnostic process should include a medical history focused on ailments related to it and their impact on the quality of patient’s life. The lack of proper control over the function of the lower urinary tract creates a lot of troubles for sufferers and prevents them from living an active professional, social, and family life. The patient with a suspicion of urinary incontinence is recommended to record in a voiding diary the number of mictions per day, the volume of urine, and episodes of incontinence. The invasive test called urodynamics is based on cystometry, profilometry, and uroflowmetry. A urodynamic examination performed in patients with incontinence allows for correct diagnosis and proposal of specific surgical or pharmacological treatment.
The Theory of Entrepreneurial Rent
Authors: Mishra Chandra S. 
Published: October 2018

Abstract
The theory of entrepreneurial rent posits that powerful incentives for managerial learning are provided by giving managers the opportunity to share the firm surplus, which further enhances the management cognition and situation awareness. These incentives enable management to seek cognitively distant opportunities that provide the firm entrepreneurial rent. Further, the greater the firm-specific risk, the greater the entrepreneurial rent. The source of entrepreneurial rent is the uncertainty associated with the firm’s value opportunities. Further, since managerial attentional resource is shared between the firm’s current operations and the exploitation of the value opportunities, the managerial attentional resources are greater when the firm has greater value opportunities.
An alternative processing pathway of APP reveals two distinct cleavage modes for rhomboid protease RHBDL4
Authors: Recinto Sherilyn Junelle , Paschkowsky Sandra , Munter Lisa Marie 
Published: October 2018

Abstract
Since the first genetic description of a rhomboid in Drosophila melanogaster, tremendous efforts have been geared towards elucidating the proteolytic mechanism of this particular class of intramembrane proteases. In particular, mammalian rhomboid proteases sparked our interest and we aimed to investigate the human homologue RHBDL4. In light of our recent finding of the amyloid precursor protein (APP) family as efficient substrates of RHBDL4, we were enticed to further study the specific proteolytic mechanism of this enzyme by comparing cleavage patterns of wild type APP and APP TMS chimeras. Here, we demonstrate that the introduction of positively charged amino acid residues in the TMS redirects the RHBDL4-mediated cleavage of APP from its ectodomain closer towards the TMS, possibly inducing an ER-associated degradation (ERAD) of the substrate. In addition, we concluded that the cytoplasmic tail and proposed palmitoylation sites in the ectodomain of APP are not essential for the RHBDL4-mediated APP processing. In summary, our previously identified APP ectodomain cleavages by RHBDL4 are a subsidiary mechanism to the proposed RHBDL4-mediated ERAD of substrates likely through a single cleavage near or within the TMS.
The Reluctant En of Inana — or the Persona of Gilgameš in the Perspective of Babylonian Political Philosophy
Authors: Steinkeller Piotr 
Published: October 2018

AbstractBoth the literary tradition and historical data proper indicate that, during the first few centuries of third millenniumBC, Babylonian kingship underwent a significant transformation. While the original leaders of city-states were primarily ritual officials, beginning at ca. 2900–2800 various individuals began emancipating themselves from their ritual roles and the concomitant power of temple households, becoming instead purely secular officials, who strived to establish an independent power base for themselves, and to create hereditary dynastic lines. This paper argues that the paragon of this development was Gilgameš, the presumed early king of Uruk, as his persona and accomplishments are presented in the Sumerian and Akkadian literary sources. Toward that end, various compositions devoted to Gilgameš are discussed, in particular, “Gilgameš, Enkidu, and the Netherworld.”
Competition between coordination bonds and hydrogen bonding interactions in solvatomorphs of copper(II), cadmium(II) and cobalt(II) complexes with 2,2′-bipyridyl and acetate
Authors: do Nascimento Neto José Antônio , da Silva Cameron Capeletti , Ribeiro Leandro , Silva Mendanha Valdo Ana Karoline , Martins Felipe Terra 
Published: October 2018

Abstract
The delicate balance among conformation, coordination bonds and hydrogen bonding has been probed in solvatomorphs of known metal-organic molecules synthesised from copper(II), cadmium(II) and cobalt(II) with acetate (OAc) and 2,2′-bipyridine (bipy). The Cu(OAc)2(bipy) complex, isolated as a pentahydrate, has the acetate ligands oriented to opposite sides of the coordination square plane. DFT calculations show the energy difference between this structure and a syn form amount to approximately 16 kJ/mol. The presence of lattice water enables the formation of O–H···O hydrogen bonds with the acetate ligands. Different coordination numbers and energies are found as a function of the number of water molecules co-crystallising in the Cd(OAc)2(bipy)(OH2)·3H2O and [Co(OAc)(bipy)2](OAc)·3H2O complexes.
DMEK IN KERATOCONUS WITH ACUTE HYDROPS: A CASE REPORT
Authors: Maranhão Lucio V L , Dantas Paulo E C , Ramalho Natalia R L , Pinto Wanessa P 
Published: October 2018

We describe the initial results of a Descemet Membrane Endothelial Keratoplasty (DMEK) procedure for acute corneal hydrops in a 45-years female with keratoconus that presented with severe visual loss in the left eye (OS). The patients’ best-corrected visual acuity at presentation in the right eye was 20/80 and hand motion in OS. Slit-lamp examination revealed an extensive Descemet’s membrane tear and stromal corneal edema in OS. Two months after the DMEK procedure, the patient presented with a best corrected visual acuity of 20/200 in the affected eye, corneal edema improvement, and an attached Descemet graft.
Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster
Authors: Miguel-Aliaga Irene , Jasper Heinrich , Lemaitre Bruno 
Published: October 2018

Abstract
The gastrointestinal tract has recently come to the forefront of multiple research fields. It is now recognized as a major source of signals modulating food intake, insulin secretion and energy balance. It is also a key player in immunity and, through its interaction with microbiota, can shape our physiology and behavior in complex and sometimes unexpected ways. The insect intestine had remained, by comparison, relatively unexplored until the identification of adult somatic stem cells in the Drosophila intestine over a decade ago. Since then, a growing scientific community has exploited the genetic amenability of this insect organ in powerful and creative ways. By doing so, we have shed light on a broad range of biological questions revolving around stem cells and their niches, interorgan signaling and immunity. Despite their relatively recent discovery, some of the mechanisms active in the intestine of flies have already been shown to be more widely applicable to other gastrointestinal systems, and may therefore become relevant in the context of human pathologies such as gastrointestinal cancers, aging, or obesity. This review summarizes our current knowledge of both the formation and function of the Drosophila melanogaster digestive tract, with a major focus on its main digestive/absorptive portion: the strikingly adaptable adult midgut.
Establishment of Transgenesis in the Demosponge Suberites domuncula
Authors: Revilla-i-Domingo Roger , Schmidt Clara , Zifko Clara , Raible Florian 
Published: October 2018

Abstract
Sponges (Porifera) represent one of the most basally branching animal clades with key relevance for evolutionary studies, stem cell biology, and development. Despite a long history of sponges as experimental model systems, however, functional molecular studies are still very difficult to perform in these animals. Here, we report the establishment of transgenic technology as a basic and versatile experimental tool for sponge research. We demonstrate that slice explants of the demosponge Suberites domuncula regenerate functional sponge tissue and can be cultured for extended periods of time, providing easy experimental access under controlled conditions. We further show that an engineered expression construct driving the enhanced green fluorescence protein (egfp) gene under control of the Suberites domuncula β-actin locus can be transfected into such tissue cultures, and that faithfully spliced transcripts are produced from such transfected DNA. Finally, by combining fluorescence-activated cell sorting (FACS) with quantitative PCR, we validate that transfected cells can be specifically reisolated from tissue based on their fluorescence. Although the number of detected enhanced green fluorescent protein (EGFP)-expressing cells is still limited, our approach represents the first successful introduction and expression of exogenous DNA in a sponge. These results represent a significant advance for the use of transgenic technology in a cornerstone phylum, for instance for the use in lineage tracing experiments.
Coalescence and Linkage Disequilibrium in Facultatively Sexual Diploids
Authors: Hartfield Matthew , Wright Stephen I , Agrawal Aneil F 
Published: October 2018

Abstract
Under neutrality, linkage disequilibrium results from physically linked sites having nonindependent coalescent histories. In obligately sexual organisms, meiotic recombination is the dominant force separating linked variants from one another, and thus in determining the decay of linkage disequilibrium with physical distance. In facultatively sexual diploid organisms that principally reproduce clonally, mechanisms of mitotic exchange are expected to become relatively more important in shaping linkage disequilibrium. Here we outline mathematical and computational models of a facultative-sex coalescent process that includes meiotic and mitotic recombination, via both crossovers and gene conversion, to determine how linkage disequilibrium is affected with facultative sex. We demonstrate that the degree to which linkage disequilibrium is broken down by meiotic recombination simply scales with the probability of sex if it is sufficiently high (much greater than 1/N for population size N). However, with very rare sex (occurring with frequency on the order of 1/N), mitotic gene conversion plays a particularly important and complicated role because it both breaks down associations between sites and removes within-individual diversity. Strong population structure under rare sex leads to lower average linkage disequilibrium values than in panmictic populations, due to the influence of low-frequency polymorphisms created by allelic sequence divergence acting in individual subpopulations. These analyses provide information on how to interpret observed linkage disequilibrium patterns in facultative sexuals and to determine what genomic forces are likely to shape them.
Accurate Genomic Prediction of Human Height
Authors: Lello Louis , Avery Steven G , Tellier Laurent , Vazquez Ana I , de los Campos Gustavo , Hsu Stephen D H 
Published: October 2018

Abstract
Hsu et al. used advanced methods from machine learning to analyze almost half a million genomes. They produced, for the first time, accurate genomic predictors for complex traits such as height, bone density, and educational attainment...
We construct genomic predictors for heritable but extremely complex human quantitative traits (height, heel bone density, and educational attainment) using modern methods in high dimensional statistics (i.e., machine learning). The constructed predictors explain, respectively, ∼40, 20, and 9% of total variance for the three traits, in data not used for training. For example, predicted heights correlate ∼0.65 with actual height; actual heights of most individuals in validation samples are within a few centimeters of the prediction. The proportion of variance explained for height is comparable to the estimated common SNP heritability from genome-wide complex trait analysis (GCTA), and seems to be close to its asymptotic value (i.e., as sample size goes to infinity), suggesting that we have captured most of the heritability for SNPs. Thus, our results close the gap between prediction R-squared and common SNP heritability. The ∼20k activated SNPs in our height predictor reveal the genetic architecture of human height, at least for common variants. Our primary dataset is the UK Biobank cohort, comprised of almost 500k individual genotypes with multiple phenotypes. We also use other datasets and SNPs found in earlier genome-wide association studies (GWAS) for out-of-sample validation of our results.
Sucrose Signaling Regulates Anthocyanin Biosynthesis Through a MAPK Cascade in Arabidopsis thaliana
Authors: Meng Lai-Sheng , Xu Meng-Ke , Wan Wen , Yu Fei , Li Cong , Wang Jing-Yi , Wei Zhi-Qin , Lv Meng-Jiao , Cao Xiao-Ying , Li Zong-Yun , Jiang Ji-Hong 
Published: October 2018

Abstract
Anthocyanin accumulation specifically depends on sucrose (Suc) signaling. However, the molecular basis of this process remains unknown. In this study, in vitro pull-down assays identified ETHYLENE-INSENSITIVE3 (EIN3), a component of both sugar signaling or/and metabolism. This protein interacted with YDA, and the physiological relevance of this interaction was confirmed by in planta co-immunoprecipitation, yeast two-hybrid (Y2H) assay, and bimolecular fluorescence complementation. Ethylene insensitive3-like 1 (eil1) ein3 double-mutant seedlings, but not ein3-1 seedlings, showed anthocyanin accumulation. Furthermore, ein3-1 suppressed anthocyanin accumulation in yda-1 plants. Thus, EMB71/YDA-EIN3-EIL1 may form a sugar-mediated gene cascade integral to the regulation of anthocyanin accumulation. Moreover, the EMB71/YDA-EIN3-EIL1 gene cascade module directly targeted the promoter of Transparent Testa 8 (TT8) by direct EIN3 binding. Collectively, our data inferred a molecular model where the signaling cascade of the YDA-EIN3-TT8 appeared to target TT8 via EIN3, thereby modulating Suc signaling–mediated anthocyanin accumulation.