bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular Adverse Reactions During Antipsychotic Treatment: Results of AMSP, A Drug Surveillance Program Between 1993 and 2013
Authors: Friedrich Michaela-Elena , Winkler Dietmar , Konstantinidis Anastasios , Huf Wolfgang , Engel Rolf , Toto Sermin , Grohmann Renate , Kasper Siegfried 
Published: August 2019

Abstract

Background
Cardiovascular diseases are still the leading cause of global mortality. Some antipsychotic agents can show severe cardiovascular side effects and are also associated with metabolic syndrome.

Methods
This observational study was based on data of AMSP (Arzneimittelsicherheit in der Psychiatrie), a multicenter drug surveillance program in Austria, Germany and Switzerland, that recorded severe drug reactions in psychiatric inpatients.

Results
A total of 404 009 inpatients were monitored between 1993 and 2013, whereas 291 510 were treated with antipsychotics either in combination or alone. There were 376 cases of severe cardiovascular adverse reactions reported in the given timespan, yielding a relative frequency of 0.13%. The study revealed that incidence rates of cardiovascular adverse reactions were highest during treatment with ziprasidone (0.35%), prothipendyl (0.32%), and clozapine (0.23%). The lowest rate of cardiovascular symptoms occurred during treatment with promethazine (0.03%) as well as with aripiprazole (0.06%). The most common clinical symptoms were orthostatic collapse and severe hypotonia, sinustachycardia, QTc prolongation, myocarditis, and different forms of arrhythmia. The dosage at the timepoint when severe cardiovascular events occurred was not higher in any of the given antipsychotics than in everyday clinical practice and was in average therapeutic ranges. In terms of subclasses of antipsychotics, no significant statistical difference was seen in the overall frequencies of adverse reactions cases, when first-generation high potency, first-generation low potency, and second-generation antipsychotics were compared. Thirty percent of adverse events among second-generation antipsychotics were induced by clozapine.

Conclusions
Our findings on cardiovascular adverse reactions contribute to a better understanding of cardiovascular risk profiles of antipsychotic agents in inpatients.
Maternal Envelope gp41 Ectodomain-Specific Antibodies Are Associated With Increased Mother-to-Child Transmission of Human Immunodeficiency Virus-1
Authors: Naiman Nicole E , Slyker Jennifer , Nduati Ruth , Overbaugh Julie M 
Published: August 2019

Abstract
Mother-to-child transmission of human immunodeficiency virus (HIV) occurs in the setting of maternal and passively acquired antibodies, providing a unique window into immune correlates of HIV risk. We compared plasma antibody binding to HIV antigens between 51 nontransmitting mother-infant pairs and 21 transmitting mother-infant pairs. Plasma antibody binding to a variety of gp41 ectodomain-containing antigens was associated with increased odds of transmission. Understanding the reasons why gp41 ectodomain-targeting antibodies are associated with transmission risk will be important in determining whether they can directly enhance infection or whether their presence reflects a redirecting of the humoral response away from targeting more protective epitopes.
Analysis of intestinal immunity and flora in a collagen-induced mouse arthritis model: differences during arthritis progression
Authors: Nemoto Nobuhito , Takeda Yuji , Nara Hidetoshi , Araki Akemi , Gazi Md Yeashin , Takakubo Yuya , Naganuma Yasushi , Takagi Michiaki , Asao Hironobu 
Published: August 2019

Abstract
Intestinal immunity and flora are reported to be associated with the onset of rheumatoid arthritis. However, differences in the intestinal immunity and flora dynamics between the initial peak and relapse of arthritis have not been investigated. Here we analyzed the lymphocyte populations in different lymphoid tissues, the IgA in feces, and the intestinal flora at the initial peak and the relapse phase of arthritis in a collagen-induced arthritis (CIA) mouse model. In this model compared with the control group, the percentage of RORγt+CD4+ T cells in the mesenteric lymph nodes (mLN) was increased at the initial peak but decreased at the relapse stage of arthritis, and the opposite changes were observed in the spleen. The percentage of Foxp3+CD4+ T cells was unchanged at the initial peak in both tissues but increased only in the mLN at the relapse stage. The IgA in feces increased with the progression of arthritis, and bacterial analysis revealed that some specific bacterial families were changed at the peak and relapse stages of arthritis. Finally, the immune dynamics under different arthritic conditions were examined by integrating these factors using principal component analysis (PCA). PCA showed that the immunological and intestinal flora profiles were different between the initial peak and the relapse of the arthritis. Our findings suggest that the intestinal immunity and the environment change drastically with the progress of arthritis.
Impact of a national guideline on use of knee arthroscopy: An interrupted time-series analysis
Authors: Kiadaliri Ali , Bergkvist Dan , Dahlberg Leif E , Englund Martin 
Published: August 2019

Abstract

Objective
To assess the impact of the Swedish health authority recommendation against the use of knee arthroscopy in patients aged ≥40 years with knee osteoarthritis (OA).

Design
Interrupted time series analysis.

Setting
Public health care in Skåne region.

Participants
Patients aged ≥40 years who underwent knee arthroscopy from January 2010 to December 2015.

Intervention(s)
National guideline’s recommendation against the use of knee arthroscopy in patients with knee OA.

Main Outcome Measure(s)
1) proportion of patients aged ≥40 years with a main diagnosis of Knee OA and/or degenerative meniscal lesions (DML) who underwent knee arthroscopy, and 2) overall knee arthroscopy rate per 100,000 Skåne population aged ≥40 years.

Results
A total of 6,155 knee arthroscopy were performed among people aged ≥40 years during study period. Of 42,044 patients with Knee OA/DML, 3,728 had knee arthroscopy. The recommendation was associated with reductions in the use of knee arthroscopy and two years after the recommendation, there was a reduction of 28.6% (95% CI: 9.3, 47.8) and 34.7% (23.9, 45.4) in proportion of Knee OA/DML patients with knee arthroscopy and the overall knee arthroscopy rate, respectively, relative to that expected if pre-recommendation trend continued. Our sensitivity analysis showed that the use of total knee replacement was stable over the study period.

Conclusion
The national recommendation was associated with reduction in use of knee arthroscopy in public health care in southern Sweden. However, still 4.5% of these patients underwent knee arthroscopy in 2015 implying that more efforts are required to achieve the recommended target.
E.H. Carr and IPE: An Essay in Retrieval
Authors: Germain Randall 
Published: August 2019

AbstractAlthough the work of E.H. Carr has a prominent place in the scholarly history of international relations (IR), it is notably absent from the discipline of international political economy (IPE). This is puzzling, because Carr's analysis of international politics places a strong emphasis on the organic connection between politics and economics on an international scale. On this reading, his principal publications on IR can also be seen to chart a sophisticated conceptualization of what I want to label historical IPE. This essay retrieves such a reading of Carr for the discipline of IPE. It begins by interrogating the way in which Carr's work has been appropriated by modern IPE scholarship, in order to highlight the limited use made of the political economy dimension of his research. I then explore the historical and political economy aspects of Carr's writings to consider how his contribution might advance recent contemporary theoretical debate in the discipline. I pay particular attention to how his work charts an historical conception of IPE that can synthesize and move beyond the rationalist/constructivist binary that currently dominates theorizing in the discipline.
Informatics opportunities to involve patients in hospital safety: a conceptual model
Authors: Haldar Shefali , Mishra Sonali R , Pollack Ari H , Pratt Wanda 
Published: August 2019

AbstractObjectiveInpatients could play an important role in identifying, preventing, and reporting problems in the quality and safety of their care. To support them effectively in that role, informatics solutions must align with their experiences. Thus, we set out to understand how inpatients experience undesirable events (UEs) and to surface opportunities for those informatics solutions.Materials and MethodsWe conducted a survey with 242 patients and caregivers during their hospital stay, asking open-ended questions about their experiences with UEs. Based on our qualitative analysis, we developed a conceptual model representing their experiences and identified informatics opportunities to support patients.ResultsOur 4-stage conceptual model illustrates inpatient experiences, from when they first encounter UEs, when they could intervene, when harms emerge, what types of harms they experience, and what they do in response to harms.DiscussionExisting informatics solutions address the first stage of inpatients’ experiences by increasing their awareness of potential UEs. However, future researchers can explore new opportunities to fill gaps in support that patients experience in subsequent stages, especially at critical decision points such as intervening in UEs and responding to harms that occur.ConclusionsOur conceptual model reveals the complex inpatient experiences with UEs, and opportunities for new informatics solutions to support them at all stages of their experience. Investigating these new opportunities could promote inpatients’ participation and engagement in the quality and safety of their care, help healthcare systems learn from inpatients’ experience, and reduce these harmful events.
Standardized ileal digestibility of amino acids in canola meal fed to gestating and lactating sows1
Authors: Velayudhan Deepak Ettungapladi , Hossain Manik M , Stein Hans H , Nyachoti C Martin 
Published: August 2019

AbstractAn experiment was conducted to determine the standardized ileal digestibility (SID) of CP and AA in solvent extracted canola meal (CM) fed to gestating and lactating sows without or with a multi-enzyme complex. Eight sows cannulated on day 40 of gestation were randomly assigned to 1 of 4 dietary treatments in a replicated 4 × 4 Latin square design. The 4 diets included 2 cornstarch-based diets with 31.3% CM as the only source of AA, without or with a multi-enzyme complex, a casein-cornstarch diet to determine ileal endogenous AA losses, and a phosphorus-free diet (phosphorus digestibility data reported elsewhere). All diets contained 0.3% titanium dioxide. Gestating sows were fed 3.0 kg/d of the respective experimental diets, whereas, during lactation, sows had ad libitum access to experimental diets. Ileal digesta samples were collected in midgestation, late gestation, and lactation. In each period, after 6-d acclimation to the experimental diets, on days 7 and 8, ileal digesta samples were collected continuously for 12 h. Results indicated that sows in lactation had greater apparent ileal digestibility (AID) of CP and all AA (P < 0.05) compared with sows in gestation. Enzyme supplementation improved (P < 0.05) the AID of histidine, lysine, methionine, valine, and alanine, and a tendency (P < 0.10) for improvement in AID was observed for arginine, isoleucine, tryptophan, and cysteine during lactation, but not during gestation. However, the SID of most AA was not affected by collection phase, but enzyme supplementation improved (P < 0.05) the SID of arginine, histidine, lysine, methionine, and valine during lactation. The SID of indispensable AA in CM fed to gestating and lactating sows were as follows: arginine, 89.2 and 91.3%; histidine, 93.1 and 94.0%; isoleucine, 85.9 and 87.0%; leucine, 89.2 and 89.2%; lysine, 87.0 and 87.7%; methionine, 92.2 and 93.2%; phenylalanine, 89.2 and 87.8%; threonine, 84.3 and 82.7%; tryptophan, 88.1 and 91.5%; valine, 85.9 and 84.3%. In conclusion, the SID of AA in CM fed to lactating sows may be improved if a mixture of carbohydrases is included in the diet, but under the conditions of this experiment, the carbohydrase mixture did not affect SID of AA in CM fed to gestating sows in midgestation or late gestation.
Observation of unexpected molecular binding activity for Mu phage tail fibre chaperones
Authors: Sakai Kohei , Iwazaki Takuma , Yamashita Eiki , Nakagawa Atsushi , Sakuraba Fumiya , Enomoto Atsushi , Inagaki Minoru , Takeda Shigeki 
Published: August 2019

AbstractIn the history of viral research, one of the important biological features of bacteriophage Mu is the ability to expand its host range. For extending the host range, the Mu phage encodes two alternate tail fibre genes. Classical amber mutation experiments and genome sequence analysis of Mu phage suggested that gene products (gp) of geneS (gpS = gp49) and gene S’ (gpS’ = gp52) are tail fibres and that gene products of geneU (gpU = gp50) and geneU’ (gpU’ = gp51) work for tail fibre assembly or tail fibre chaperones. Depending on the gene orientation, a pair of genes 49-50 or 52-51 is expressed for producing different tail fibres that enable Mu phage to recognize different host cell surface. Since several fibrous proteins including some phage tail fibres employ their specific chaperone to facilitate folding and prevent aggregation, we expected that gp50 or gp51 would be a specific chaperone for gp49 and gp52, respectively. However, heterologous overexpression results for gp49 or gp52 (tail fibre subunit) together with gp51 and gp50, respectively, were also effective in producing soluble Mu tail fibres. Moreover, we successfully purified non-native gp49-gp51 and gp52-gp50 complexes. These facts showed that gp50 and gp51 were fungible and functional for both gp49 and gp52 each other.
The impact of AGN on stellar kinematics and orbits in simulated massive galaxies
Authors: Frigo Matteo , Naab Thorsten , Hirschmann Michaela , Choi Ena , Somerville Rachel S , Krajnovic Davor , Davé Romeel , Cappellari Michele 
Published: August 2019

ABSTRACT
We present a series of 10 × 2 cosmological zoom simulations of the formation of massive galaxies with and without a model for active galactic nucleus (AGN) feedback. Differences in stellar population and kinematic properties are evaluated by constructing mock integral field unit maps. The impact of the AGN is weak at high redshift when all systems are mostly fast rotating and disc-like. After z ∼ 1 the AGN simulations result in lower mass, older, less metal rich, and slower rotating systems with less discy isophotes – in general agreement with observations. 2D kinematic maps of in situ and accreted stars show that these differences result from reduced in-situ star formation due to AGN feedback. A full analysis of stellar orbits indicates that galaxies simulated with AGN are typically more triaxial and have higher fractions of x-tubes and box orbits and lower fractions of z-tubes. This trend can also be explained by reduced late in-situ star formation. We introduce a global parameter, ξ3, to characterize the anticorrelation between the third-order kinematic moment h3 and the line-of-sight velocity (Vavg/σ), and compare to ATLAS3D observations. The kinematic correlation parameter ξ3 might be a useful diagnostic for large integral field surveys as it is a kinematic indicator for intrinsic shape and orbital content.
Insights from the APOKASC determination of the evolutionary state of red-giant stars by consolidation of different methods
Authors: Elsworth Yvonne , Hekker Saskia , Johnson Jennifer A , Kallinger Thomas , Mosser Benoit , Pinsonneault Marc , Hon Marc , Kuszlewicz James , Miglio Andrea , Serenelli Aldo , Stello Dennis , Tayar Jamie , Vrard Mathieu 
Published: August 2019

ABSTRACTThe internal working of low-mass stars is of great significance to both the study of stellar structure and the history of the Milky Way. Asteroseismology has the power to directly sense the internal structure of stars and allows for the determination of the evolutionary state – i.e. has helium burning commenced or is the energy generated only by the fusion in the hydrogen-burning shell? We use observational data from red-giant stars in a combination (known as APOKASC) of asteroseismology (from the Kepler mission) and spectroscopy (from SDSS/APOGEE). The new feature of the analysis is that the APOKASC evolutionary state determination is based on the comparison of diverse approaches to the investigation of the frequency-power spectrum. The high level of agreement between the methods is a strong validation of the approaches. Stars for which there is not a consensus view are readily identified. The comparison also facilitates the identification of unusual stars including those that show evidence for very strong coupling between p and g cavities. The comparison between the classification based on the spectroscopic data and asteroseismic data have led to a new value for the statistical uncertainty in APOGEE temperatures. These consensus evolutionary states will be used as an input for methods that derive masses and ages for these stars based on comparison of observables with stellar evolutionary models (‘grid-based modelling’) and as a training set for machine-learning and other data-driven methods of evolutionary state determination.
V1082-Sgr: A magnetic cataclysmic variable with a lobe-filling companion star
Authors: Xu Xiaojie , Shao Yong , Li Xiang-Dong 
Published: August 2019

ABSTRACT
V1082 Sgr is a cataclysmic variable with accretion luminosity above 1034 erg s−1, indicating a mass-transfer rate above $10^{-9}\, \mathrm{M}_{\odot }$  yr−1. However, its K-type companion was suggested to be underfilling its Roche lobe (RL), making the high mass-transfer rate a mystery. In this work we propose a possible model to explain this discrepancy. The system is proposed to be an intermediate polar, with its K-type companion filling its RL. The mass of the white dwarf star is evaluated to be $0.77\pm 0.11\, \mathrm{M}_{\odot }$ from both X-ray continuum fitting and Fe line flux ratio measurements. We make numerical simulations to search for the possible progenitors of the system. The results show that a binary with an initial 1.5–2.5$\, \mathrm{M}_{\odot }$ companion in a one to two day orbit (or an initial 1.0–1.4$\, \mathrm{M}_{\odot }$ companion in a 3.2–4.1 d orbit) may naturally evolve to a cataclysmic variable with a $\sim 0.55 \pm 0.11\, \mathrm{M}_{\odot }$, Roche-lobe-filling companion in a 0.86 d orbit. The effective temperature of the donor star, the mass-transfer rate, and the derived V-band magnitude are all consistent with previous observations.
On the nature of the resonant drag instability of dust streaming in protoplanetary disc
Authors: Zhuravlev V V 
Published: August 2019

Abstract
The recently discovered resonant drag instability (RDI) of dust streaming in protoplanetary disc is considered as the mode coupling of subsonic gas-dust mixture perturbations. This mode coupling is coalescence of two modes with nearly equal phase velocities: inertial wave (IW) having positive energy and a streaming dust wave (SDW) having negative energy as measured in the frame of gas environment being at rest in vertical hydrostatic equilibrium. SDW is a trivial mode produced by the bulk streaming of dust, which transports perturbations of dust density. In this way, settling combined with radial drift of the dust makes possible coupling of SDW with IW and the onset of the instability. In accordance with the concept of the mode coupling, RDI growth rate is proportional to the square root of the coupling term of the dispersion equation, which itself is proportional to mass fraction of dust, f ≪ 1. This clarifies why RDI growth rate ∝f1/2. When SDW has positive energy, its resonance with IW provides an avoided crossing instead of the mode coupling. In the high wavenumber limit RDI with unbounded growth rate ∝f1/3 is explained by the triple mode coupling, which is coupling of SDW with two IW. It coexists with a new quasi-resonant instability accompanied by bonding of two oppositely propagating low-frequency IW. The mode coupling does not exist for dust streaming only radially in a disc. In this case RDI is provided by the obscured mechanism associated with the inertia of solids.
Stochastic Gene Expression Influences the Selection of Antibiotic Resistance Mutations
Authors: Sun Lei , Ashcroft Peter , Ackermann Martin , Bonhoeffer Sebastian 
Published: August 2019

AbstractBacteria can resist antibiotics by expressing enzymes that remove or deactivate drug molecules. Here, we study the effects of gene expression stochasticity on efflux and enzymatic resistance. We construct an agent-based model that stochastically simulates multiple biochemical processes in the cell and we observe the growth and survival dynamics of the cell population. Resistance-enhancing mutations are introduced by varying parameters that control the enzyme expression or efficacy. We find that stochastic gene expression can cause complex dynamics in terms of survival and extinction for these mutants. Regulatory mutations, which augment the frequency and duration of resistance gene transcription, can provide limited resistance by increasing mean expression. Structural mutations, which modify the enzyme or efflux efficacy, provide most resistance by improving the binding affinity of the resistance protein to the antibiotic; increasing the enzyme’s catalytic rate alone may contribute to resistance if drug binding is not rate limiting. Overall, we identify conditions where regulatory mutations are selected over structural mutations, and vice versa. Our findings show that stochastic gene expression is a key factor underlying efflux and enzymatic resistances and should be taken into consideration in future antibiotic research.
miRDB: an online database for prediction of functional microRNA targets
Authors: Chen Yuhao , Wang Xiaowei 
Published: August 2019

Abstract
MicroRNAs (miRNAs) are small noncoding RNAs that act as master regulators in many biological processes. miRNAs function mainly by downregulating the expression of their gene targets. Thus, accurate prediction of miRNA targets is critical for characterization of miRNA functions. To this end, we have developed an online database, miRDB, for miRNA target prediction and functional annotations. Recently, we have performed major updates for miRDB. Specifically, by employing an improved algorithm for miRNA target prediction, we now present updated transcriptome-wide target prediction data in miRDB, including 3.5 million predicted targets regulated by 7000 miRNAs in five species. Further, we have implemented the new prediction algorithm into a web server, allowing custom target prediction with user-provided sequences. Another new database feature is the prediction of cell-specific miRNA targets. miRDB now hosts the expression profiles of over 1000 cell lines and presents target prediction data that are tailored for specific cell models. At last, a new web query interface has been added to miRDB for prediction of miRNA functions by integrative analysis of target prediction and Gene Ontology data. All data in miRDB are freely accessible at http://mirdb.org.