bluuebunny/crossref_metadata_2025_split huggingface dataset:
High chromosomal instability is associated with higher 10‐year risks of recurrence for hormone receptor‐positive, human epidermal growth factor receptor 2‐negative breast cancer patients: clinical evidence from a large‐scale, multiple‐site, retrospective study
Authors: Liao Yu‐Yang , Fu Jianfei , Lu Xiang , Qian Ziliang , Yu Yang , Zhu Liang , Pan Jia‐Ni , Li Pu‐Chun , Zhu Qiao‐Yan , Li Xiaolin , Sun Wenyong , Wang Xiao‐Jia , Cao Wen‐Ming 
Published: November 2024

AbstractLong‐term survival varies among hormone receptor‐positive (HR+) and human epidermal growth factor receptor 2‐negative (HER2−) breast cancer patients and is seriously impaired by metastasis. Chromosomal instability (CIN) was one of the key drivers of breast cancer metastasis. Here we evaluate CIN and 10‐year invasive disease‐free survival (iDFS) and overall survival (OS) in HR+/HER2−– breast cancer. In this large‐scale, multiple‐site, retrospective study, 354 HR+/HER2− breast cancer patients were recruited. Of these, 204 patients were used for internal training, 70 for external validation, and 80 for cross‐validation. All medical records were carefully reviewed to obtain the disease recurrence information. Formalin‐fixed paraffin‐embedded tissue samples were collected, followed by low‐pass whole‐genome sequencing with a median genome coverage of 1.86X using minimal 1 ng DNA input. CIN was then assessed using a customized bioinformatics workflow. Three or more instances of CIN per sample was defined as high CIN and the frequency was 42.2% (86/204) in the internal cohort. High CIN correlated significantly with increased lymph node metastasis, vascular invasion, progesterone receptor negative status, HER2 low, worse pathological type, and performed as an independent prognostic factor for HR+/− breast cancer. Patients with high CIN had shorter iDFS and OS than those with low CIN [10‐year iDFS 11.1% versus 82.2%, hazard ratio (HR) = 11.12, p < 0.01; 10‐year OS 45.7% versus 94.3%, HR = 14.17, p < 0.01]. These findings were validated in two external cohorts with 70 breast cancer patients. Moreover, high CIN could predict the prognosis more accurately than Adjuvant! Online score (10‐year iDFS 11.1% versus 48.6%, HR = 2.71, p < 0.01). Cross‐validation analysis found that high consistency (83.8%) was observed between CIN and MammaPrint score, while only 45% between CIN and Adjuvant! Online score. In conclusion, high CIN is an independent prognostic indicator for HR+/HER2− breast cancer with shorter iDFS and OS and holds promise for predicting recurrence and metastasis.
Pharmacokinetics, Efficacy, and Safety of Upadacitinib in Pediatric Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis: An Interim Analysis of an Open‐Label, Phase 1 Trial
Authors: Brunner Hermine I. , Shmagel Anna , Horneff Gerd , Foeldvari Ivan , Antón Jordi , Ramanan Athimalaipet V. , Qian Yuli , Unnebrink Kristina , Hao Shuai , Camp Heidi S. , Khan Nasser , Liu Wei , Mohamed Mohamed‐Eslam F. 
Published: November 2024

ObjectiveThis work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA).MethodsIn an open‐label, phase 1 study (SELECT‐YOUTH), enrolled patients, aged 2 to <18 years with pcJIA, received body weight–based upadacitinib doses using a twice‐daily oral solution or once‐daily extended‐release tablet based on their body weight and ability to swallow tablets. The study included a 7‐day pharmacokinetic assessment, followed by a long‐term efficacy and safety evaluation for up to 156 weeks, including an additional long‐term safety cohort. This interim analysis included available pharmacokinetic and safety data and efficacy data collected through week 48.ResultsA total of 57 patients received upadacitinib. The median time to maximum upadacitinib concentration was approximately three hours and one hour for the tablet and oral solution regimens, respectively; the harmonic mean functional half‐life was approximately five hours and two hours, respectively. Juvenile idiopathic arthritis American College of Rheumatology 30, 50, 70, 90, and 100 responses at week 12 were 91.8%, 89.8%, 69.4%, 49.0%, and 32.7%, respectively. Efficacy was generally maintained through week 48, and improvement in additional efficacy end points was also observed. At a median exposure duration of 412 days, 52 of 57 patients reported adverse events; of these, 6 experienced serious adverse events. Adverse events were predominately mild to moderate in severity and consistent with the known safety profile of upadacitinib.ConclusionThis interim analysis demonstrates that the bodyweight‐based dosing regimen of upadacitinib was well tolerated and efficacious in pediatric patients with pcJIA.
Multifunctional Reconfigurable Vanadium Dioxide Integrated Metasurface for Reflection, Asymmetric Transmission and Cross‐Polarization Conversion in Terahertz Region
Authors: Nguyen Thi Quynh Hoa , Nguyen Thi Minh 
Published: November 2024

AbstractIntegrating reconfigurable and diverse functionalities into a single metasurface at terahertz (THz) frequencies is an emerging research topic that faces significant challenges. Here, a reconfigurable THz metasurface is proposed, offering diversified functionalities based on the phase transition of vanadium dioxide (). The proposed metasurface can switch from wideband reflection to wideband cross‐polarization conversion (CPC) and asymmetric transmission (AT) for linearly polarized waves. When is in its fully metallic state, the metasurface efficiently reflects normally incident waves ranging from 0.2 to 2.8 THz, with total reflection exceeding 0.8. When is in its insulating state, the metasurface achieves nearly perfect wideband cross‐polarization conversion with CPC efficiency above 0.99 from 0.46 to 2.67 THz, and excellent AT effect with efficiency over 0.9 from 0.65 to 2.29 THz for normal incidence of linearly polarized waves. Moreover, the high efficiency of CPC and AT effects is maintained over a wide range of incident angles. The proposed switchable metasurface with diverse functionalities is expected to enable cutting‐edge research and innovative applications in THz communication, sensing, and imaging.
Acoustic Tunable Battery‐Free Implants Based on Sustainable Triboelectric Nanogenerators With Metal‐Polymer Intermixing Layers
Authors: Chung Youngwook , Yuan Hongwei , Wang Ze , Jeong Jang‐Mook , Park Byung‐Joon , Hwang Joon‐Ha , Suh Su‐Jeong , Choi Byung‐Ok , Park Hyun‐moon , Kim Young‐Jun , Dai Keren , Kim Sang‐Woo 
Published: November 2024

AbstractUltrasound‐driven triboelectric nanogenerators (US‐TENGs) offer an innovative solution for transcutaneous power transfer, with the potential to enable battery‐free, permanently implantable electronics. However, research to date has primarily demonstrated only fragmentary functionalities for these applications. This work presents the simultaneous transmission of acoustic power and precise acoustic information using a double‐electrode US‐TENG, enabling a battery‐free implant controlled via ultrasound. High and sustained output from a US‐TENG is crucial for operating the versatile system; therefore, a novel triboelectric membrane with a top electrode incorporating a gold‐polymer intermixing layer has been designed. Reversible micro‐cracks form in the intermixing layer, ensuring electrical connectivity under high‐frequency strain. In vivo experiments confirm that the system is biocompatible and can be reliably operated inside living rats. These achievements represent a significant step toward realizing multifunctional implantable electronics that can be reliably powered and controlled by ultrasound.
Long‐Term Single‐Molecule Tracking in Living Cells using Weak‐Affinity Protein Labeling
Authors: Catapano Claudia , Dietz Marina S. , Kompa Julian , Jang Soohyen , Freund Petra , Johnsson Kai , Heilemann Mike 
Published: November 2024

AbstractSingle‐particle tracking (SPT) has become a powerful tool to monitor the dynamics of membrane proteins in living cells. However, permanent labeling strategies for SPT suffer from photobleaching as a major limitation, restricting observation times, and obstructing the study of long‐term cellular processes within single living cells. Here, we use exchangeable HaloTag Ligands (xHTLs) as an easy‐to‐apply labeling approach for live‐cell SPT and demonstrate extended observation times of individual living cells of up to 30 minutes. Using the xHTL/HaloTag7 labeling system, we measure the ligand‐induced activation kinetics of the epidermal growth factor receptor (EGFR) in single living cells. We generate spatial maps of receptor diffusion in cells, report non‐uniform distributions of receptor mobility, and the formation of spatially confined ‘hot spots’ of EGFR activation. Furthermore, we measured the mobility of an ER‐luminal protein in living cells and found diffusion coefficients that correlated with the ER nano‐structure. This approach represents a general strategy to monitor protein mobility in a functional context and for extended observation times in single living cells.
Karl Ziegler – Early Career of a Scientist
Authors: Kießling Christoph 
Published: November 2024

AbstractKarl Ziegler is considered one of the most outstanding chemists of the 20th century. In particular, his work on organometallic mixed catalysts, which allows the polymerization of ethylene at normal pressure, led to a revolution in plastics production and changed the everyday life of all mankind. In 1963, he was awarded the Nobel Prize in Chemistry for this work, together with Giulio Natta. This article focuses on Ziegler's early career, which has received little attention to date. It describes his youth and study years in Marburg, which partly coincide with the First World War. Subsequently, his postdoctoral period is examined, which led him via Marburg and Frankfurt to his first associate professorship in Heidelberg. Special attention is paid to his relationship to National Socialism, which he opposed. As a result, Ziegler experienced professional difficulties in the 1930s, such as repeated rejection when filling various professorships. His appointment as a full professor in Halle and his subsequent directorship at the Max‐Planck‐Institut für Kohlenforschung (Coal Research), where he finally achieved his greatest research achievement, are described in the following.
An Overview of Microfluidic‐Assisted Strategies for Synthesis and Applications of Molecularly Imprinted Polymers
Authors: Karunakaran Ramya , Onorati Chiara Luna , Amreen Khairunnisa , Goel Sanket , Lieberzeit Peter A. 
Published: November 2024

AbstractThis review gives an overview of using microfluidics in conjunction with molecularly imprinted polymers (MIP), which covers two aspects: on the one hand, on‐chip synthesis of polymer and MIP particles on the nano and the micro scale. This comprises both approaches using two different immiscible solvents and homogeneous matrices to obtain the desired particle morphologies. On the other hand, especially paper‐based microfluidic systems have attracted increasing interest as low‐cost analytical tools that are inherently useful for applying at the point of care. By now, there have been several successful attempts to combine them with MIP (instead of biological recognition systems) and to successfully apply them in environmental samples, food matrices, and for diagnostic applications.
Water Industry Communications: Vital Tools to Engage Stakeholders and Build Trust
Authors: Shackelford Douglas , Hoyt Monica B. , Cawby Mandy , Smith Kelley Dearing 
Published: November 2024

Key TakeawaysAdvancing a utility's communications assets not only supports its efforts to ensure public trust and comply with regulations but also furthers operational goals.From a strategic perspective, water utility communications go well beyond reaching customers and stakeholders to unite utility teams and garner industry recognition.Closing the gap between utilities and their communities, effective communications can help utilities cultivate customer advocates who support water system efforts.
An Update on Taste, Odor, and Appearance Methods for Water Analysis
Authors: Shawwa Ayman , Adams Hunter , Burlingame Gary A. , Dietrich Andrea M. 
Published: November 2024

Key TakeawaysMany sensory methods are standardized, and new ones are being developed, to assess the aesthetic quality of source water and treated drinking water.In Standard Methods for the Examination of Water and Wastewater, sections 2110 and 2150 have been updated, and section 2150D, “Attribute Rating Test” (ART), has been added.ART is a technique for numerically rating water samples by sensory evaluation for the presence of taste and odor compounds.Sensory tests—screening panelists for their ability to smell compounds—should be part of a utility's sensory program.
Designing a Water Pipeline to Last 100 Years or More
Authors: Habibian Ahmad , Sever V. Firat 
Published: November 2024

Key TakeawaysAlthough superior materials and advanced techniques are available, designing a pipeline to supply water for 100 years or more is not necessarily the optimal choice for a utility.Numerous factors come into play when planning for pipe design, installation, monitoring, and maintenance, not the least of which is uncertainty about the future.Tools such as computational modeling, life‐cycle cost analysis, forensic analysis, and scenario planning through digital design can help a utility create a cost‐effective pipeline plan.
Society for Birth Defects Research and Prevention Symposium: Health Disparities Within Communities of Color
Authors: Vera‐Colón Madeline K. M. , Huerta‐Montañez Gredia , Kancherla Vijaya , Anto‐Ocrah Martina , Myer Michelle , Silva Marilyn Helen 
Published: November 2024

ABSTRACTBackgroundHigh‐risk pregnancies and birth defects are often greater within communities of color where resources for a healthy pregnancy are generally lacking. Infant and maternal mortality, preterm birth, and instances of increased developmental and physical defects are related to environmental exposures (e.g., pesticides, lead in water, wildfire smoke), dietary additives, and lack of access to adequate healthcare. More frequently people of color and other under‐served groups, are affected by historical inequality and unconscious bias. Compounding these disparities, research into these issues and efforts to address them are poorly supported.MethodsThe speakers in this symposium presented evidence for health disparities within communities of color to foster research aimed at identifying toxic levels of potentially hazardous dietary chemicals, or exposures in the pediatric population can focus on addressing the current inadequacy of translating scientific findings into enforceable policies.ResultsThe disparities discussed within this symposium highlighted key areas in desperate need of policy reform. In the United States, regulatory exposure levels have been established for lead exposures but frequently exceed these limits without mitigation. Neural tube defects can be prevented by a simple dietary solution such as fortification of staple foods with folic acid. Recent literature on gender as a social determinant of health has determined women suffer more negative health consequences due to social attitudes.ConclusionsUltimately, this symposium provided an understanding of the experience of disadvantaged and marginalized persons during pregnancy, illustrated the disparities that exist in reproductive health, and described the need to address and prevent them.
Gliosarcoma: A Multi‐Institutional Analysis on Clinical Outcomes and Prognostic Factors
Authors: Roohani Siyer , Mirwald Maximilian , Ehret Felix , Fink Christoph , König Laila , Striefler Jana Käthe , Jacob Noelle Samira , Popp Ilinca , Steffel Johannes , Handtke Jolina , Claßen Noa Marie , Rotermund Titus , Zips Daniel , Vajkoczy Peter , Schüller Ulrich , Spałek Mateusz Jacek , Kaul David 
Published: November 2024

ABSTRACTPurposeThis study describes oncological outcomes and investigates prognostic factors for patients with gliosarcomas (GSM).MethodsHistopathologically confirmed GSM patients who underwent treatment at five European institutions were retrospectively analyzed.ResultsWe analyzed 170 patients with a median clinical follow‐up time of 9.2 months. The majority received surgery (94.1%), postoperative radiotherapy (pRT, 81.8%), and temozolomide (TMZ)‐based postoperative chemotherapy (66.5%). The median overall survival (OS) and progression‐free survival (PFS) were 12.3 and 6.6 months, respectively. In the multivariable Cox regression analysis (MVA), the following factors were significantly associated with OS: age per year (hazard ratio (HR): 1.03, p < 0.001), subtotal resection (STR) versus biopsy only (HR: 0.15, p = 0.018), gross total resection (GTR) versus biopsy only (HR: 0.13, p = 0.011), pRT versus no pRT (HR: 0.20, p < 0.001), postoperative TMZ‐based chemotherapy versus no postoperative chemotherapy (HR: 0.44, p = 0.003), MGMT promoter non‐methylated versus methylated (HR: 1.79, p = 0.05), and tumor diameter per cm (HR: 1.15, p = 0.046). For PFS, the following factors were significantly associated in the MVA: GTR versus biopsy only (HR: 0.19, p = 0.026), pRT versus no pRT (HR: 0.36, p = 0.006), postoperative TMZ‐based chemotherapy vs. no postoperative chemotherapy (HR: 0.39, p < 0.001), MGMT promoter status unknown versus methylated (HR: 1.69, p = 0.034), and tumor diameter per cm (HR: 1.18, p = 0.016). Sex, primary or secondary GSM, and TP53 mutational status were not significantly associated with OS or PFS.ConclusionsTrimodal therapy comprising surgical resection, pRT and TMZ‐based chemotherapy appears to have the most beneficial effect on survival in GSM patients. Smaller tumor size, younger age and methylated MGMT promoters are associated with improved survival. To our knowledge, this is the largest multi‐institutional cohort study investigating outcomes and prognostic factors for GSM.
Development of an Antiviral Medicinal Plant and Natural Product Database (avMpNp Database) from Biodiversity
Authors: Quadros de Azevedo Daniela , Vinícius Viera Nóia João , Ribeiro Yasmim Carla M. , Alves dos Reis Raphael , Ribeiro Paulo Henrique Otoni , Almeida Moura Gustavo , Mendes Pamela , Barbosa de Souza Ana Beatriz , Carpini Mermejo Sofia , Serafim Mateus Sá Magalhães , Fernandes Thaís Helena Maciel , O'Donoghue Anthony J. , Campos Alessandra C. Faria Aguiar , Campos Sérgio Vale Aguiar , Gonçalves Maltarollo Vinícius , Oliveira Castilho Rachel 
Published: November 2024

AbstractThe construction of compound databases (DB) is a strategy for the rational search of bioactive compounds and drugs for new and old diseases. In order to bring greater impact to drug discovery, we propose the development of a DB of bioactive antiviral compounds. Several research groups have presented evidence of the antiviral activity of medicinal plants and compounds isolated from these plants. We believe that compiling these discoveries in a DB would benefit the scientific research community and increase the speed to discover new potential drugs and medicines. Thus, we present the Antiviral Medicinal Plant and Natural Product DB (avMpNp DB) as an important source for acquiring, organizing, and distributing knowledge related to natural products and antiviral drug discovery. The avMpNp DB contains a series of chemically diverse compounds with drug‐like profiles. To test the potential of this DB, SARS‐CoV‐2 Mpro and PLpro enzymatic inhibition assays were performed for available compounds resulting in IC50 values ranging from 6.308±0.296 to 15.795±0.155 μM. As a perspective, artificial intelligence tools will be added to implement computational predictions, as well as other chemical functionalities that allow data validation.
Investigating the Antiproliferative Activity of Novel 4‐Chloro‐8‐Nitro‐1,2‐Dihydro‐3‐Quinoline Acylhydrazones on Human Cervical Cancer Cell Lines
Authors: Nandakumar Vandana , Selvi Ramasamy Sentamil , Adhigaman Kaviyarasu , Arumugam Deepak , Ramasamy Shankar , Vivek Raju , Athimoolam Shunmuganarayanan , Thangaraj Suresh 
Published: November 2024

AbstractA new series of acyl hydrazones have been synthesized from 4‐chloro‐8‐nitro‐1,2‐dihydroquinoline‐3‐carbaldehyde. These compounds were characterized using various spectroscopic techniques. Density functional theoretical (DFT) studies were conducted to understand the correlation between electronic parameters and biological activity. The biological activity of the compounds was theoretically examined through molecular docking and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis. The compounds demonstrated high absorption rates and were found to be non‐hepatotoxic. Preliminary cytotoxicity screenings against HeLa cell lines identified compound 7 as the most potent, with an IC50 value of 18.8 μM. This compound was further selected for bioimaging studies. The results indicate that compound 7 induces apoptosis at its IC50 concentration, suggesting its potential as an anticancer agent.
Benzofuran‐Chalcone Derivatives as VEGFR‐2 Inhibitors: Synthesis and Anticancer Evaluation
Authors: Liu Yixin , Zhang Chunfei , Zhang Xiao , Wan Chunping , Mao Zewei 
Published: November 2024

ABSTRACTThe discovery and development of efficient VEGFR‐2 inhibitors has become a research hotspot in cancer treatment. In this work, a series of new benzofuran‐based chalcone derivatives have been prepared, and in vitro anticancer activities have been evaluated. The results revealed that derivatives showed selective cytotoxic activity against HCC1806, Hela, and A549 cell lines, especially 5c exhibited excellent inhibitory effect on VEFGR‐2 (IC50 = 1.07 nM). The molecular docking study indicated that 5c had an obvious binding site with the target VEGFR‐2 (PDB ID: 3V6B). Therefore, the benzofuran‐based chalcone derivatives could be considered as potent VEGFR‐2 inhibitors for further study.
Effect of Ischemia Testing and Coronary Revascularization on Mortality and Ventricular Tachycardia Recurrence in Patients With Monomorphic Ventricular Tachycardia Without Acute Coronary Syndrome: A Meta‐Analysis and Systematic Review
Authors: Shah Nischay , Saraiya Avinash , Patel Tejas , Marchlinski Francis E. , Pancholy Samir 
Published: November 2024

ABSTRACTBackgroundStudies show mixed results regarding the effect of coronary revascularization on mortality benefit and ventricular tachycardia (VT) recurrence in patients with monomorphic VT without acute coronary syndrome (ACS). This meta‐analysis aimed to assess the effect of ischemia testing and/or coronary revascularization on mortality and VT recurrence in a pooled data set.MethodsDatabases including PubMed, Google Scholar, and the Cochrane Library were searched from January 2000 to December 2023 for studies reporting event data on mortality and VT recurrence in patients without ACS who presented with monomorphic VT. Data were pooled and analyzed using random effects meta‐analysis.ResultsThe pooled sample consisted of a total of five studies, with 1062 patients, of whom 433 underwent ischemia testing and/or coronary revascularization and 629 did not. There was no statistically significant difference in the mortality and VT recurrence in the patients who underwent ischemia testing and/or revascularization versus those who did not (mortality odds ratio [OR]: 0.98; [95% confidence interval (CI): 0.62 to 1.53]; p = 0.92; VT recurrence OR: 1.07; [95% CI: 0.51 to 2.26]; p = 0.86). No publication bias was detected by examination of the funnel plot, Begg−Mazumdar's test (p = 0.80), and Egger's test (p = 0.91).ConclusionIn conclusion, in patients with sustained monomorphic VT in the absence of ACS, ischemia testing and/or revascularization does not lead to improved mortality or a decrease in the incidence of VT recurrence.