bluuebunny/crossref_metadata_2025_split huggingface dataset:
How can manufacturers identify the conditions for financially viable product-as-a-service?
Authors: Vogt Duberg Johan , Sakao Tomohiko 
Published: November 2024

IntroductionWith the much-needed transformation from linear to more circular resource flows, it is imperative for enterprises to understand their financial prospects. Transforming towards Product-as-a-Service (PaaS) with circular elements introduces new considerations that must be addressed to ensure profitability and sustainability. However, there is a lack of comprehensive financial assessments based on empirical cases to guide companies in assessing the lucrativeness of their transformations. This paper addresses this gap by proposing a simple-to-use and flexible financial assessment model for PaaS, helping practitioners identify the conditions necessary for financial viability from both provider and user perspectives.MethodsGrounded in transdisciplinary research, this study focuses on a construction machine manufacturer's transformation from a traditional one-off sales business model to PaaS. The transformation is analysed through the development of a life cycle costing financial assessment model that addresses relevant cost drivers.ResultsUsing discounting methods, the model can help practitioners generate scenarios to identify feasible solutions for profitable PaaS setups. Additionally, the paper presents an analytical procedure to identify conditions for a financially viable PaaS. The procedure includes scenario-based analysis that accounts for systemic changes often necessary for successfully realising PaaS.DiscussionBy following the proposed procedure, along with the financial assessment model, manufacturers can streamline their financial assessments to identify necessary changes. For the analysed case company, the modelling results indicate that it must redesign its products for PaaS to outperform its previous business model.
Predictive effect of nonarteritic anterior ischemic optic neuropathy on the development of cerebral small vessel disease: a retrospective study
Authors: Han Xu , Li Hongyang , Meng Zhaoyang , Wang Yanling 
Published: November 2024

ObjectiveThe study aims to determine the correlation between cerebral small vessel diseases (SVDs) and nonarteritic anterior ischemic optic neuropathy (NAION). Additionally, investigate whether NAION raises the risk of an increased total cerebral small vessel disease score (CSVD score) compared to control group without ocular conditions.Methods101 controls without any retinal illness and 61 individuals with NAION were enrolled for this retrospective case control study. Ophthalmic examinations and brain magnetic resonance imaging (MRI) scans were performed on all participants. Data on demographics and clinical characteristics were obtained from hospital medical records. We evaluated and compared the distribution of SVDs and rated the total CSVD score based on SVD indications observed on MRI scans.ResultsSVDs were more frequently in NAION individuals than in control group (82%, p &lt; 0.001), and their odds ratio was 4.11 (95%CI: 1.93–8.79, p &lt; 0.001). The ordinal logistic regression showed patients in NAION group had 3.08-, 5.66- and 2.90-times higher risk than in control group, at each point of the white matter hyperintensity (WMH) score (95%CI: 1.43–6.79, p = 0.003), perivascular spaces (PVS) score (95%CI: 2.31–14.9, p &lt; 0.001) and CSVD score (95%CI: 1.32–6.51, p = 0.005) respectively. Dyslipidemia presented a higher risk in the presence of SVDs (p = 0.008, OR = 2.31, 95%CI: 1.20–4.44) and WHM score (p = 0.018, OR = 2.22, 95%CI: 1.07–4.70). There was no significant difference between NAION group and controls in sex, age, or other past medical characteristics.ConclusionThe predictive effect of NAION on SVDs is possible as NAION patients have an increased risk with SVDs. Brain MRI scans and the control of risk factors associated with SVDs should be recommended for individuals who develop NAION.
Bibliometric analysis of global research trends and prospects on circulating tumor DNA in colorectal cancer
Authors: Pang Jing , Bai Pengyu , Zhang Yong , Wang Lichun 
Published: November 2024

BackgroundColorectal cancer (CRC) is one of the most commonly diagnosed advanced-stage malignancies worldwide and places a substantial burden on both the economic and social development of numerous countries.ObjectiveThis manuscript aims to synthesize the existing evidence and explore potential avenues for future scholarly research on ctDNA in CRC.MethodsBibliometric analyses were performed using the bibliometrix package in R, along with CiteSpace and VOSviewer software. The search was restricted to publications up to 31 March 2024, using the following terms: (“ctDNA” OR “circulating tumor DNA”) AND (“colorectal cancer” OR “colorectal tumor”) from the Web of Science Core Collection (WoSCC) database.ResultsUltimately, we identified 1,310 documents published in 353 journals authored by 7,683 researchers from 2,417 institutions across 66 countries. The USA was the most productive country. The Journal of Clinical Oncology was the most prolific, publishing 111 articles with 3,396 citations. The top five keywords were “colorectal cancer,” “circulating tumor DNA,” “acquired resistance,” “cell-free DNA,” and “plasma.” The top five cluster labels for references were “advanced cancer,” “metastatic colorectal cancer,” “liquid biopsy,” “colorectal cancer,” and “human colorectal cancer xenograft.”ConclusionsThe collaborative networks are primarily composed of highly productive authors, prestigious institutions, and leading countries. Additionally, the advancement of detection technologies, the development of standardized protocols, the exploration of circulating tumor DNA (ctDNA) dynamics in CRC, and the implementation of large-scale clinical trials for ctDNA-guided precision therapy in CRC are expected to become major research priorities in the future.
Advancing EGFR mutation subtypes prediction in NSCLC by combining 3D pretrained ConvNeXt, radiomics, and clinical features
Authors: Hao Peng , Yu Yinghong , Huang Chan-Tao , Zhou Fang , Xu Yi-Kai , Yang Jiancheng , Xu Jun 
Published: November 2024

PurposeThe aim of this study was to develop a novel approach for predicting the expression status of Epidermal Growth Factor Receptor (EGFR) and its subtypes in patients with Non-Small Cell Lung Cancer (NSCLC) using a Three-Dimensional Convolutional Neural Network (3D-CNN) ConvNeXt, radiomics features and clinical features.Materials and methodsA total of 732 NSCLC patients with available CT imaging and EGFR expression data were included in this retrospective study. The region of interest (ROI) was manually segmented, and clinicopathological features were collected. Radiomic and deep learning features were extracted. The instances were randomly divided into training, validation, and test sets. Feature selection was performed, and XGBoost was used to create solo models and combined models to predict the presence of EGFR and subtypes mutations. The effectiveness of the models was assessed using ROC and PRC curves.ResultsWe established the following models: ModelCNN, Modelradiomic, Modelclinical, ModelCNN+radiomic, ModelCNN+clinical, Modelradiomic+clinical, and ModelCNN+radiomic+clinical, which were based on deep learning features, radiomic features, clinical data and combinations of these, respectively. In predicting EGFR mutations, ModelCNN+radiomic+clinical demonstrated superior performance compared to other prediction models, achieving an AUC of 0.801. For distinguishing between EGFR subtypes ex19del and L858R, ModelCNN+radiomic reached the highest AUC value of 0.775.ConclusionsBoth deep learning models and radiomic signature-based models offer reasonably accurate non-invasive predictions of EGFR status and its subtypes. Fusion models hold the potential to enhance noninvasive methods for predicting EGFR mutations and subtypes, presenting a more reliable prediction approach.
Population pharmacokinetic study of the effect of polymorphisms in the ABCB1 and CES1 genes on the pharmacokinetics of dabigatran
Authors: Yang Zhuan , Tan Wen Rui , Li Qin , Wang Ying , Liu Shijing , Chen Lu , Zhou Yan , Zeng Chen , Zeng Yan , Xiong Yun , Zhang Qian , Li Na , Du Peng , Liu Lin , Chen Jiyu , He Yan 
Published: November 2024

PurposeThe impact of genetic polymorphisms in the ABCB1 and CES1 genes on dabigatran plasma concentrations remains a subject of debate, and the purpose of this study was to quantitatively assess the effects of genetic polymorphisms on dabigatran esters in healthy Chinese subjects employed a population pharmacokinetic (PopPK) approach.MethodsIn total, 1,926 pharmacokinetic (PK) samples from 123 healthy individuals who were given 150 mg of dabigatran orally during a fasting state or postprandially were analyzed using the PopPK model. A two-compartment model with first-order absorption was found to adequately describe the PK data.ResultsThe results showed that covariates food intake and ABCB1 SNP rs4148738 were shown to have statistically significant impacts. Specifically, in postprandial administration increased lag time (ALAG) and clearance (CL) by 2.65% and 0.51%, respectively, and decreased absorption rate constant (KA) by 0.24%. Additionally, in subjects with CT genotype ABCB1 (rs4148738), the central ventricular volume of distribution (V2) was increased by 0.38%.ConclusionIn summary, the PopPK model developed in this study was robust and effectively characterized the pharmacokinetics of dabigatran in healthy Chinese adults, demonstrating that both food and ABCB1 genetic variation significantly influence the absorption and plasma concentration levels of dabigatran.
Effects of school-based high-intensity interval training on health-related fitness in adolescents
Authors: Jovanović Rade , Živković Mladen , Stanković Mima , Zoretić Dajana , Trajković Nebojša 
Published: November 2024

BackgroundHigh-intensity interval training (HIIT) in school settings has been much less studied in adolescents. The aim of this study was to examine the impact of HIIT on health-related fitness in adolescents.MethodsThe total sample consisted of 60 adolescents (age 16.33 ± 0.62 years) from secondary Grammar school, randomly divided into two groups: the experimental (EG) (30) and the control group (CG) (30). The experimental program (12-weeks; 2 times per week) involved two Tabata sessions during one physical education class lasting 4 min each. Participants were tested for health-related fitness components-cardiorespiratory fitness (The Shuttle Run Test (SRT) and strength, hand grip test, standing long jump (SLJ) and counter movement jump (CMJ).ResultsBoth the EG and the CG experienced significant positive changes in SRT (meters) and VO2max values compared to baseline value (p &lt; 0.05), however, the increase in the EG was significantly higher than that in the CG (SRT - ηp2 = 0.111; VO2max - ηp2 = 0.111, p &lt; 0.01). The EG showed significant improvement in SRT (meters) and VO2max values compared to the CG (p &lt; 0.01). Regarding the hand grip test results, a significant time × group interaction was found only for right hand (p &lt; 0.01). Moreover, the improvements in SLJ and CMJ values was greater in EG than that in the CG group (SLJ- ηp2 = 0.182; CMJ- ηp2 = 0.112, p &lt; 0.01).ConclusionFindings indicate that HIIT implemented into physical education classes can result in significant improvements in selected health related fitness components in adolescents.
The relationship between neuroticism as a personality trait and mindfulness skills: a scoping review
Authors: Angarita-Osorio Natalia , Escorihuela Rosa M. , Cañete Toni 
Published: November 2024

IntroductionIn recent decades, researchers have assessed the relationship between mindfulness and personality traits, including neuroticism, a known target in mental health associated with the development of mental health disorders and physical illnesses. The main aim of mindfulness practice is to help individuals develop the ability to regulate and accept their experiences, emotions, and thoughts. Therefore, it could be suggested that mindfulness may be useful in reducing the expression and negative experience of neuroticism. The aim of our review was to assess the relationship between neuroticism and mindfulness.MethodsWe conducted a scoping review of the literature in December 2023, using the databases PubMed and PsycINFO.ResultsForty-nine studies were included in the review, with four common themes identified: (i) mental health, (ii) cognitive outcomes, (iii) physiological symptoms, and (iv) mindfulness-based interventions. Across most of the studies, mindfulness negatively correlated with neuroticism, supporting the idea that mindfulness may be useful in reducing neuroticism and its negative effects on mental and physical health.DiscussionWhile several limitations were identified, the overall results are promising. Future research in this area should focus on overcoming the current limitations to provide a better understanding of the relationship between mindfulness and neuroticism.
Association between omega-3 index and depersonalization among healthcare workers in a university hospital: a cross-sectional study
Authors: Antao Helena Sofia , Sacadura-Leite Ema , Aguiar Pedro , Gois Carlos , Marques Jessica , Pombo Samuel , Figueira Maria Luisa 
Published: November 2024

IntroductionBurnout harms workers physical and mental health due to induced brain changes, autonomous nervous system and hypothalamus-pituitary-adrenal axis excessive activation. Although several correlations and risk factors have been identified, the research around burnout biological correlates remains underdeveloped. The omega-3 index has been proposed in mental health as a contributor to identify high risk patients and monitor disease advancements but the evidence on its relationship with burnout is limited. This study is meant to test the hypothesis that the omega-3 index is inversely associated with burnout levels and to discuss its potential as a biological correlate of burnout.MethodsIt had an observational, cross-sectional design and was carried out at a university hospital center between March 2021 and July 2023. We invited 319 healthcare professionals (doctors and nurses) at the occupational health and emergency departments. The omega- 3 index was determined through a prick finger test. Emotional exhaustion, depersonalization and personal accomplishment were measured by the Maslach Burnout Inventory. Descriptive analyses were conducted to examine the participants’ characteristics and outcome variables. Means, medians, interquartile ranges and standard deviations were calculated for continuous variables. Frequencies and percentages were obtained for categorical variables. We have used the individual dimensions’ scores as continuous data in the evaluation of their relationship with the omega-3 index. The relationship between burnout levels and the omega-3 index was assessed through linear regression analysis. ResultsWe surveyed 300 subjects (94% response rate). High emotional exhaustion and depersonalization were reported by 29.9% and 22.1% of participants, respectively; 26.0% reported low personal accomplishment. The mean omega-3 index was 5.75%. The depersonalization score was, on average, 11.132 points higher (95% CI [4.661; 17.603]) in individuals whose omega-3 index was lower than 4%.DiscussionAn omega-3 index below 4% seems to potentially be a biological correlate of depersonalization. Our results contribute to enlarging the knowledge about burnout biological correlates, an area that has been previously signalled as underdeveloped. Omega-3 index should be included in prospective studies that will investigate the evolution of other burnout biological correlates as the syndrome emerges and progresses in subjects at risk.
The staff perspectives of facilitators and barriers to implementing virtual reality for people living with dementia in long-term care
Authors: Wong Joey , Wong Karen Lok Yi , Kan Winnie , Wu Catherine , Upreti Mona , Van Mary , Temirova Alisha , Alfares Hadil , Wen Kayla , Sharma Vaishali , Wallsworth Christine , Mann Jim , Wong Lily , Hung Lillian 
Published: November 2024

IntroductionOne emerging technology in long-term care (LTC) is virtual reality (VR), an innovative tool that uses head-mounted devices to provide the viewer with an immersive experience. It has been shown that VR has a positive impact on the well-being of residents living with dementia, and staff are essential in the implementation and sustainable use of technology. Currently, there is a lack of inclusion and focus on direct staff perspectives on VR implementation in LTC. This paper aims to report staff perspectives on VR adoption in a 2-year study on a virtual reality program at three Canadian LTC homes.MethodsOur interdisciplinary team (clinicians, people living with dementia and family partners, trainees, and researchers) explored the facilitators and barriers to implementing VR in LTC, guided by the Consolidated Framework for Implementation Research (CFIR) and intersectionality supplemented CFIR. Twenty-one participants were recruited, including recreation staff, care aides, nurses, screeners, and leadership team members. The team collected data through staff interviews, focus groups, and ethnographic observation field notes. Reflexive thematic analysis was performed to identify themes reporting the facilitators and barriers for VR implementation in LTC from staff perspectives.ResultsThe data analysis resulted in three facilitators and four barriers. Facilitators are (1) perceived VR benefits, (2) integrate VR into workflow and routines, and (3) partner with skillful VR champions. Barriers include (1) staff concerns about VR use, (2) financial burden and competing priorities, (3) lack of infrastructure and physical spaces, and (4) staff workload and limited leadership support.DiscussionThis study contributes to the field with staff perspectives on facilitators and barriers to VR implementation. It underscores the rarely discussed aspects of VR implementation, such as funding prioritization and implementation timing. We offer practical strategies to inform future practices and research. Future studies should further explore long-term VR implementation, the involvement of family members as VR facilitators, and the use of VR in LTC.
Effects of early marriage among women married before reaching 18 years old (qualitative study approach)
Authors: Gelchu Adola Shiferaw , Wirtu Dessalegn 
Published: November 2024

BackgroundThe consequences of early marriage have become a global concern for young women. The detrimental effects of early marriage disproportionately affect girls. Regarding its effects in poor nations like Ethiopia, there is a dearth of data. As a result, this study offers baseline, first-hand, and updated information for both the nation and the study area.ObjectiveThe purpose of this study was to investigate the effects of early marriage on Guji women who were married before the age of 18.MethodsThis qualitative study used a phenomenological approach and was carried out from January to April 2024. An in-depth interview technique was employed to collect the data. The interviews were conducted in the Oromo language. A purposive sampling technique was applied to choose the study participants. A total of 25 women who met the eligibility criteria were selected. A thematic data analysis approach was employed to analyze the data in this study.ResultsThree themes, 10 subthemes, and more than hundreds of codes were extracted after the interview data were analyzed. The main themes and subthemes of this study were as follows: 1-Precipitators of early marriage (abduction and arranged marriage); 2-Consequences of early marriage (emotional damage, moral damage, early marriage is a risk factor for maternal and child health, early marriage is a major cause for girls to drop out of school, poverty, gender-based violence and divorce, lack of essential life skills); and 3-Attitudes toward early marriage (early marriage is a harmful cultural practice; girls should be protected).ConclusionThe study’s findings illustrated the multidimensional effect of early marriage, necessitating the involvement of numerous sectors and stakeholders. The community, religious leaders, the health, education, and legal sectors, as well as the parents of young girls, should all take an active role in delaying early marriage. This indicates the development of policies that permit cooperation amongst all relevant parties. Creating awareness among girls, families, and the community through community-based education is crucial. Early married women should participate in intervention programs to provide their experience to young girls. Women who are victims of early marriage must receive full support to mitigate its negative consequences.
Phytochemicals from Passiflora coriacea Juss. Have Anti-Inflammatory and Neuroprotective Effects in Mouse Models
Authors: Castolo-Sanchez Samir , Zamilpa Alejandro , Herrera-Ruiz Maribel , Trejo-Espino José Luis , Domínguez-Mendoza Blanca Eda , González-Cortazar Manasés , Trejo-Tapia Gabriela 
Published: November 2024

Background: Neuroinflammatory diseases trigger an inflammatory response and a state of oxidative stress. Passiflora coriacea Juss. has been used to treat conditions related to inflammatory processes in the central nervous system; however, to date, there has been no study on the anti-inflammatory and neuroprotective effects of this species. Methods: The anti-inflammatory effect of P. coriacea was evaluated in a TPA-induced auricular edema model, and the percentage of edema inhibition (Ei) was recorded. The Morris water maze was used to assess the neuroprotective effect, measuring the latency time (LT), and lipopolysaccharide was administered to induce neuroinflammation. The concentrations of cytokines (IL-6, IL-10, and TNF-α) and activities of antioxidant system components (CAT, SOD, GR, NO, and MDA) were measured in the mouse brains. The chemical composition was determined using chromatographic and nuclear magnetic resonance techniques. Results: T1.1, T2.1, and T3.1 showed anti-inflammatory (Ei = 92.5, 88.3, and 64.8%, respectively) and neuroprotective (LT = 27.2, 22.9, and 27.7 s, respectively) effects. T1.1 was identified as scopolin with immunomodulatory (IL-6 = 3307 pg/g) and antioxidant (CAT = 1198 mmol, SOD = 23%, GR = 5.34 units/mL, NO = 11.5 µM, MDA = 1526 nmol/mL) effects; T2.1 was a mixture of terpenes (fitone, 7-dehydrodiosgenin, tremulone) with immunomodulatory (TNF-α = 857 pg/g) and antioxidant (CAT = 1245 mmol, NO = 8.75 µM) effects; and T3.1 was a mixture of isoquercetin and astragalin with immunomodulatory (IL-6 = 3135 pg/g, IL-10 = 1300 pg/g, TNF-α = 751 pg/g) and antioxidant (SOD = 1204 nmol/mL, CAT = 1131 nmol/mL, NO = 6.37 µM, MDA = 1204 nmol/mL) effects. Conclusions: The administration of P. coriacea treatments generated anti-inflammatory, neuroprotective, immunomodulatory, and antioxidant effects. These effects are attributable to its chemical composition, comprising scopolin, terpenes, and a mixture of isoquercetin and astragalin, which have not previously been described in this species.