bluuebunny/crossref_metadata_2025_split huggingface dataset:
The liturgy of the in-between
Authors: Adiprasetya Joas 
Published: February 2019

AbstractBy using the idea of theology as symbolic engagement, I propose the ‘in-between’ as a liturgical category that engages with multiple tensions in Christian theology. The concept of the in-between becomes the primary lens through which to analyse not only the relationship between ecclesial and social liturgies, but also the interstices between the two. I then apply the concept to construct theological imagination in the ministries of ushering, intercessory prayer and the sending. The article concludes with a story of the worship of the GKI Yasmin church in front of the presidential palace in Indonesia, which demonstrates the prophetic dimension of the in-between.
Early assessment of innovation in a healthcare setting
Authors: Støme Linn Nathalie , Moger Tron , Kidholm Kristian , Kværner Kari J. 
Published: February 2019

AbstractObjectivesEarly assessment can assist in allocating resources for innovation effectively and produce the most beneficial technology for an institution. The aim of the present study was to identify methods and discuss the analytical approaches applied for the early assessment of innovation in a healthcare setting.MethodsKnowledge synthesis based on a structured search (using the MEDLINE, Embase, and Cochrane databases) and thematic analysis was conducted. An analytical framework based on the stage of innovation (developmental, introduction, or early diffusion) was applied to assess whether methods vary according to stage. Themes (type of innovation, study, analysis, study design, method, and main target audience) were then decided among the authors. Identified methods and analysis were discussed according to the innovation stage.ResultsA total of 1,064 articles matched the search strategy. Overall, thirty-nine articles matched the inclusion criteria. The use of methods has a tendency to change according to the stage of innovation. Stakeholder analysis was a prominent method in the innovation stages and particularly in the developmental stage, as the introduction and early diffusion stage has more availability of data and may apply more complex methods. Barriers to the identified methods were also discussed as all of the innovation stages suffered from lack of data and substantial uncertainty.ConclusionsAlthough this review has identified applicable approaches for early assessment in different innovation stages, research is required regarding the value of the available data and methods and tools to enhance interactions between different parties at different stages of innovation.
Evolutionary changes in the orbits and palatal openings of early tetrapods, with emphasis on temnospondyls
Authors: WITZMANN Florian , RUTA Marcello 
Published: February 2019

ABSTRACTOpen palates with large interpterygoid vacuities are a diagnostic characteristic of temnospondyl amphibians, the most species-rich group of early tetrapods. Aside from their functional roles, several other aspects of such vacuities, such as their variation and spatial relationships relative to the orbits, have received only scarce attention. The present work examines patterns of shape and size changes in the orbits and vacuities of temnospondyls using a time-calibrated phylogeny of 69 temnospondyl taxa and 13 additional early tetrapod ‘outgroups' (colosteids, an embolomere, ‘microsaurs' and nectrideans). Orbit and vacuity outlines are quantified in a comparative framework using standard eigenshape analyses. In addition, we employ a series of ratios of linear measurements of both orbits and vacuities, and subject them to a phylogenetic principal component analysis in order to evaluate their proportional changes relative to the skull and to one another. Finally, we examine rates of evolutionary change and their associated shifts for shape and size for both structures, and assess the strength and significance of the correlations between these two variables using phylogenetic generalised least squares analyses. Although orbits and vacuities have fairly simple outlines, they both reveal complex models of proportional change across the temnospondyl phylogeny. These changes exhibit strong phylogenetic signal, that is, trait covariance among taxa is predicted by tree topology. We discuss the hypothesis that, early in tetrapod evolution, the functional role of the vacuities was related to the accommodation of the anterior jaw muscles. Only later in evolution did such vacuities serve to accommodate the eye muscles only.
Current challenges to the concept of sustainability
Authors: Vogt Markus , Weber Christoph 
Published: February 2019

Non-technical summaryIn this paper we discuss current challenges to the sustainability concept. This article focuses on seven dimensions of the concept. These dimensions are crucial for understanding sustainability. Even today, the literature contains basic misunderstandings about these seven dimensions. This article sketches such fallacies in the context of global and planetary sustainability. The sustainability concept has been criticized as a content-empty ‘fuzzy notion’ or non-committal ‘all-purpose glue’. This article thus has a critical intention of reflecting the sustainability concept accurately. The aim is to contribute a better understanding of the concept.
Stability of antioxidant vitamins in whole human blood during overnight storage at 4°C and frozen storage up to 6 months
Authors: Leonard Scott W. , Bobe Gerd , Traber Maret G. 
Published: February 2019

Abstract. To determine optimal conditions for blood collection during clinical trials, where sample handling logistics might preclude prompt separation of erythrocytes from plasma, healthy subjects (n=8, 6 M/2F) were recruited and non-fasting blood samples were collected into tubes containing different anticoagulants (ethylenediaminetetra-acetic acid (EDTA), Li-heparin or Na-heparin). We hypothesized that heparin, but not EDTA, would effectively protect plasma tocopherols, ascorbic acid, and vitamin E catabolites (α- and γ-CEHC) from oxidative damage. To test this hypothesis, one set of tubes was processed immediately and plasma samples were stored at −80°C, while the other set was stored at 4°C and processed the following morning (~30 hours) and analyzed, or the samples were analyzed after 6 months of storage. Plasma ascorbic acid, as measured using HPLC with electrochemical detection (LC-ECD) decreased by 75% with overnight storage using EDTA as an anticoagulant, but was unchanged when heparin was used. Neither time prior to processing, nor anticoagulant, had any significant effects upon plasma α- or γ-tocopherols or α- or γ-CEHC concentrations. α- and γ-tocopherol concentrations remained unchanged after 6 months of storage at −80°C, when measured using either LC-ECD or LC/mass spectrometry. Thus, refrigeration of whole blood at 4°C overnight does not change plasma α- or γ-tocopherol concentrations or their catabolites. Ascorbic acid is unstable in whole blood when EDTA is used as an anticoagulant, but when whole blood is collected with heparin, it can be stored overnight and subsequently processed.
Comparison of Serum Vitamin D Levels in Relation to Bowel and Bladder Symptoms in Women with Vulvar Diseases
Authors: Swenson Carolyn W. , Schimpf Megan O. , Menees Stacy B. , Haefner Hope K. , Berger Mitchell B. 
Published: February 2019

Abstract. Objectives: We sought to investigate associations between vitamin D levels and bowel and bladder disorders in women with vulvar diseases. Methods: This is a planned sub-analysis of a cross-sectional study comparing the prevalence of bowel and bladder symptoms in women with biopsy-proven vulvar lichen sclerosus (LS) to a control group of women with non-lichenoid vulvar diseases. All subjects were recruited from a tertiary referral vulvar care clinic in a university-based practice. Serum vitamin D levels were measured and subjects self-completed questionnaires during study recruitment. Pelvic floor disorders were determined from the following questionnaires: Rome III Functional Bowel Disorders Questionnaire, the Bristol stool scale, the Medical, Social and Epidemiologic Aspects of Aging Questionnaire, and the Overactive Bladder-8 Question Version. Results: 181 women with vulvar diseases were included: 88 with LS and 93 with non-LS vulvar diseases. The mean age was 52.5 ± 15.3 years, and 94.5% were Caucasian. Vitamin D levels (26.8 ± 13.1 vs 29.5 ± 19.0 ng/mL), prevalence of low vitamin D levels (51.1% vs 45.2%), and vitamin D supplementation (42.0% vs 47.8%) were similar in women with and without LS ( p ≥ 0.27). These factors did not differ between women with and without overactive bladder (OAB) (vitamin D levels 30.1 ± 17.8 vs 26.3 ± 14.8 ng/mL), urinary incontinence (27.9 ± 15.2 vs 26.4 ± 11.0 ng/mL), constipation (26.7 ± 14.8 vs 28.5 ± 16.8 ng/mL), or irritable bowel syndrome (IBS) (30.8 ± 22.1 vs 27.6 ± 13.4 ng/mL). Conclusions: In this cohort of women with vulvar diseases, vitamin D levels and supplementation were not significantly different amongst women with vulvar lichen sclerosus or other non-lichenoid vulvar diseases. Furthermore, vitamin D levels are not serum biomarkers for OAB, urinary incontinence, constipation, or IBS.
Association Between Health Literacy, eHealth Literacy, and Health	Outcomes Among Patients With Long-Term Conditions
Authors: Neter Efrat , Brainin Esther 
Published: February 2019

Abstract. The objective of this paper is to synthesize and update findings from systematic review on health literacy and health outcomes among patients with long-term conditions, and extend the review to the digital domain. Health outcomes include clinical outcomes, processes of care, and health service use. Data sources are the following: (1) studies which appeared in two previous systematic reviews in 2004 and 2011 whose participants were people with long-term conditions or elderly ( n = 54); (2) articles on health literacy and health outcomes identified in an updated 2011–2016 search ( n = 26); (3) articles on eHealth literacy and its association with health outcomes ( n = 8). Strength of evidence was determined by a qualitative assessment of risk of bias, consistency, and directness. There was a lack of consistent evidence on the relationship between health literacy and clinical outcomes despite the consistent evidence on the association with mortality. There was low to insufficient evidence on the association between health literacy and self-rated health/function and emotional states of anxiety and depression, alongside high evidence on lack of association with quality of life. There was insufficient to low evidence on the association between health literacy and behavioral outcomes (medication adherence, other health behaviors) and finally also low to moderate evidence on the association between health literacy and use of health services such as hospitalization and emergency department. In the eHealth literacy domain, there were few studies reporting association with health behaviors and self-rated health with inconsistent results. In conclusion, it is advocated to examine performed heath literacy and eHealth literacy in large longitudinal studies.
Impact of the Sunda Shelf on the Climate of the Maritime Continent
Authors: Sarr Anta‐Clarisse , Sepulchre Pierre , Husson Laurent 
Published: February 2019

AbstractDrastic paleogeography changes in the Indonesian archipelago over the Plio‐Pleistocene, either in response to sea level oscillations or vertical land motion, enabled the periodic emergence of the Sunda shelf. When emerged, this wide continental platform in the heart of the Maritime Continent may have modified regional and global climate systems. We investigate the effect of the exposure of the Sunda shelf on climate dynamics using a set of numerical simulations with (i) atmosphere‐land surface and (ii) fully coupled general circulation models. We first explore the impact of convection schemes on the rainfall regime simulated over the Maritime Continent and show how they could explain the discrepancies among previous studies. We further depict a robust and common mechanism that prevails. We show that diurnal heating of the surface of the continental platform enhances low‐level convergence and local convection, and fosters local precipitations. This effect, to a second order, is modulated by the radiative effect and increased turbulent heat flux driven by vegetated surface properties such as albedo or roughness. Increasing precipitations over the exposed platform also impacts freshwater export into seawater, making salinity of the Indian Ocean and Indonesian Throughflow highly dependent on the routing scheme over the exposed shelf.
Is There a Bulldozer in your Model?
Authors: Lazarus Eli D. , Goldstein Evan B. 
Published: February 2019

AbstractDeliberate, real‐time human interventions into geomorphic processes are a phenomenon that no off‐the‐shelf numerical model of morphodynamics is built to capture. We suggest that active, responsive human processes that affect sediment transport during major storm events be included in evolving efforts to model geomorphic change.
Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice
Authors: Woodward Nicholas C. , Crow Amanda L. , Zhang Yang , Epstein Sam , Hartiala Jaana , Johnson Richard , Kocalis Heidi , Saffari Arian , Sankaranarayanan Ishwarya , Akbari Omid , Ramanathan Gajalakshmi , Araujo Jesus A. , Finch Caleb E. , Bouret Sebastien G. , Sioutas Constantinos , Morgan Todd E. , Allayee Hooman 
Published: February 2019

AbstractEmerging evidence from epidemiological and animal studies suggests that exposure to traffic-related air pollutants and particulate matter less than 2.5 µm in diameter (PM2.5) contributes to development of obesity and related metabolic abnormalities. However, it is not known whether nanoscale particulate matter (nPM) with aerodynamic diameter ≤200 nm have similar adverse metabolic effects. The goal of the present study was to determine the effects of prenatal and early life exposure to nPM on metabolic homeostasis in mice. C57BL/6 J mice were exposed to nPM or filtered air from gestation until 17 weeks of age and characterized for metabolic and behavioral parameters. In male mice, nPM exposure increased food intake, body weight, fat mass, adiposity, and whole-body glucose intolerance (p < 0.05). Consistent with these effects, male mice exposed to nPM displayed alterations in the expression of metabolically-relevant neuropeptides in the hypothalamus and decreased expression of insulin receptor signaling genes in adipose (p < 0.05). There were no differences in exploratory behavior or motor function, fasting lipid levels, or the inflammatory profile of adipose tissue. Our results provide evidence that chronic nPM exposure from gestation to early adulthood in male mice promotes metabolic dysregulation in part through modulation of feeding behavior and in the absence of an obesogenic diet.
Association of Obesity with Hearing Impairment in Adolescents
Authors: Scinicariello Franco , Carroll Yulia , Eichwald John , Decker John , Breysse Patrick N. 
Published: February 2019

AbstractHearing loss (HL) is the third most common chronic physical condition in the United States. Obesity has become an increasingly important public health concern, as the prevalence in children, adolescents and adults has increased over the past few decades. The objectives of this study is to investigate whether obesity is associated with audiometric notches indicative of noise-induced hearing loss (NIHL), speech frequency hearing loss (SFHL), and high frequency hearing loss (HFHL) in adolescent participants of the National Health and Nutrition Examination Survey 2007–2010. The prevalence of overall audiometric notches in the adolescent population was 16.0% with higher prevalence in females than males. The prevalence of SFHL and HFHL were higher in males than females (SFHL, 7.3% vs. 5.4%, respectively; and HFHL 14.3% vs. 8.1%, respectively). Obese adolescents had a higher adjusted OR to have audiometric notches (OR = 1.93; 95% CI: 1.33–2.81) and HFHL (OR = 1.95; 95% CI: 1.19–3.21). Continued preventative efforts towards reducing obesity might also help to reduce the risk for HL and NIHL.
Determination of the absolute configurations of the stereogenic centers of ustilaginoidins by studying the biosynthetic monomers from a gene knockout mutant of Villosiclava virens
Authors: Lai Daowan , Meng Jiajia , Xu Dan , Zhang Xuping , Liang Yafeng , Han Yu , Jiang Cong , Liu Huiquan , Wang Chenfang , Zhou Ligang , Xu Jin-Rong 
Published: February 2019

AbstractUstilaginoidins are a kind of mycotoxins with 9,9′-linked bis-naphtho-γ-pyrones structures produced by the rice false smut pathogen Villosiclava virens. These metabolites displayed a wide range of bioactivities, such as teratogenic, cytotoxic, phytotoxic, and antibacterial activities. So far 26 ustilaginoidins have been isolated from V. virens, among which 18 compounds contained stereogenic center(s), however, most of them were unknown for the absolute configurations, except that of ustilaginoidin D. In this study, the absolute structures of these ustilaginoidins were constructed for the first time by analysis of the biosynthetic monomers obtained from a gene knockout mutant (ΔUV_2091) of V. virens. The gene UV_2091 was predicted to encode an enzyme that dimerized the monomeric naphtho-γ-pyrones in V. virens. Knockout of this gene led to the accumulation of three monomers, namely hemiustilaginoidin F (1), epihemiustilaginoidin D (2), and hemiustilaginoidin D (3), but the production of ustilaginoidins was completely blocked. The structures of the monomers were deduced by spectroscopic analysis, in combination with TDDFT ECD calculations for determining the absolute configurations. These compounds were tested for their phytotoxic, cytotoxic, antibacterial, and antifungal activities. Compounds 1 and 3 showed inhibition against the radicle and plumule elongation of rice and lettuce seeds at the tested concentrations. Compound 1 was active against the tested five human cancer cells, with half maximal inhibitory concentrations (IC50s) of 13.2~37.3 μM. Compounds 1~3 inhibited the growth of the tested pathogenic bacteria with minimum inhibitory concentrations of 8~32 µg/mL, while compound 3 exhibited antifungal activity against Magnaporthe oryzae (IC50, 5.21 µg/mL). A comparison of these data with those of the ustilaginoidins provided insights into the structure-bioactivity relationships.
Revealing membrane alteration in cells overexpressing CA IX and EGFR by Surface-Enhanced Raman Scattering
Authors: Rusciano Giulia , Sasso Emanuele , Capaccio Angela , Zambrano Nicola , Sasso Antonio 
Published: February 2019

AbstractSensitive detection of altered proteins expression in plasma membranes is of fundamental importance, for both diagnostic and prognostic purposes. Surface-Enhanced Raman Scattering (SERS) has proven to be a quite sensitive approach to detect proteins, even in very diluted samples. However, proteins detection in complex environment, such as the cellular membrane, is still a challenge. Herein, we demonstrate a SERS-based platform to reveal the overexpression of target proteins in cell membranes. As a proof of concept, we implemented ectopic expression of carbonic anhydrase IX (CA IX) and epidermal growth factor receptor (EGFR) in the plasma membrane of the SKOV3 tumor cell line. Our outcomes demonstrate that SERS signals from cells put in contact with a hyperuniform SERS substrate allow highlighting subtle differences in the biochemical composition of cell membranes, normally hidden in spontaneous Raman confocal microscopy. This opens new opportunities for a label-free membrane analysis and bio-sensing in a broader sense.
Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Achieve Similar Early Improvements in Beta-cell Function in Obese Patients with Type 2 Diabetes
Authors: Mullally Jamie A. , Febres Gerardo J. , Bessler Marc , Korner Judith 
Published: February 2019

AbstractBariatric surgery is a treatment option for obese patients with type 2 diabetes mellitus (T2DM). Although sleeve gastrectomy (SG) is growing in favor, some randomized trials show less weight loss and HbA1c improvement compared with Roux-en-Y gastric bypass (RYGB). The study objective was to compare changes in beta-cell function with similar weight loss after SG and RYGB in obese patients with T2DM. Subjects undergoing SG or RYGB were studied with an intravenous glucose tolerance test before surgery and at 5–12% weight loss post-surgery. The primary endpoint was change in the disposition index (DI). Baseline BMI, HbA1c, and diabetes-duration were similar between groups. Mean total weight loss percent was similar (8.4% ± 0.4, p = 0.22) after a period of 21.0 ± 1.7 days. Changes in fasting glucose, acute insulin secretion (AIR), and insulin sensitivity (Si) were similar between groups. Both groups showed increases from baseline to post-surgery in DI (20.2 to 163.3, p = 0.03 for SG; 31.2 to 232.9, p = 0.02 for RYGB) with no significant difference in the change in DI between groups (p = 0.53). Short-term improvements in beta-cell function using an IVGTT were similar between SG and RYGB. It remains unclear if longer-term outcomes are better after RYGB due to greater weight loss and/or other factors.
Phononic topological insulators based on six-petal holey silicon structures
Authors: Yu Ziqi , Ren Zongqing , Lee Jaeho 
Published: February 2019

AbstractSince the discovery of the Quantum Spin Hall Effect, electronic and photonic topological insulators have made substantial progress, but phononic topological insulators in solids have received relatively little attention due to challenges in realizing topological states without spin-like degrees of freedom and with transverse phonon polarizations. Here we present a holey silicon-based topological insulator design, in which simple geometric control enables topologically protected in-plane elastic wave propagation up to GHz ranges with a submicron periodicity. By integrating a hexagonal lattice of six small holes with one central large hole and by creating a hexagonal lattice by themselves, our design induces zone folding to form a double Dirac cone. Based on the hole dimensions, breaking the discrete translational symmetry allows the six-petal holey silicon to achieve the topological phase transition, yielding two topologically distinct phononic crystals. Our numerical simulations confirm inverted band structures and demonstrate backscattering-immune elastic wave transmissions through defects including a cavity, a disorder, and sharp bends. Our design also offers robustness against geometric errors and potential fabrication issues, which shows up to 90% transmission of elastic waves even with 6% under-sized or 11% over-sized holes. These findings provide a detailed understanding of the relationship between geometry and topological properties and pave the way for developing future phononic circuits.