bluuebunny/crossref_metadata_2025_split huggingface dataset:
β-N-methylamino-L-alanine (BMAA) suppresses cell cycle progression of non-neuronal cells
Authors: Okamoto Saki , Esumi Shigeyuki , Hamaguchi-Hamada Kayoko , Hamada Shun 
Published: December 2018

Abstractβ-N-methylamino-L-alanine (BMAA), a natural non-proteinaceous amino acid, is a neurotoxin produced by a wide range of cyanobacteria living in various environments. BMAA is a candidate environmental risk factor for neurodegenerative diseases such as amyotrophic lateral sclerosis and Parkinson-dementia complex. Although BMAA is known to exhibit weak neuronal excitotoxicity via glutamate receptors, the underlying mechanism of toxicity has yet to be fully elucidated. To examine the glutamate receptor-independent toxicity of BMAA, we investigated the effects of BMAA in non-neuronal cell lines. BMAA potently suppressed the cell cycle progression of NIH3T3 cells at the G1/S checkpoint without inducing plasma membrane damage, apoptosis, or overproduction of reactive oxygen species, which were previously reported for neurons and neuroblastoma cells treated with BMAA. We found no evidence that activation of glutamate receptors was involved in the suppression of the G1/S transition by BMAA. Our results indicate that BMAA affects cellular functions, such as the division of non-neuronal cells, through glutamate receptor-independent mechanisms.
Structural basis for two efficient modes of agropinic acid opine import into the bacterial pathogen Agrobacterium tumefaciens
Authors: Marty Loïc , Vigouroux Armelle , Aumont-Nicaise Magali , Pelissier Franck , Meyer Thibault , Lavire Céline , Dessaux Yves , Moréra Solange 
Published: December 2018

Abstract
Agrobacterium tumefaciens pathogens genetically modify their host plants to drive the synthesis of opines in plant tumors. The mannityl-opine family encompasses mannopine, mannopinic acid, agropine and agropinic acid. These opines serve as nutrients and are imported into bacteria via periplasmic-binding proteins (PBPs) in association with ABC transporters. Structural and affinity data on agropine and agropinic acid opines bound to PBPs are currently lacking. Here, we investigated the molecular basis of AgtB and AgaA, proposed as the specific PBP for agropine and agropinic acid import, respectively. Using genetic approaches and affinity measurements, we identified AgtB and its transporter as responsible for agropine uptake in agropine-assimilating agrobacteria. Nonetheless, we showed that AgtB binds agropinic acid with a higher affinity than agropine, and we structurally characterized the agropinic acid-binding mode through three crystal structures at 1.4, 1.74 and 1.9 Å resolution. In the crystallization time course, obtaining a crystal structure of AgtB with agropine was unsuccessful due to the spontaneous lactamization of agropine into agropinic acid. AgaA binds agropinic acid only with a similar affinity in nanomolar range as AgtB. The structure of AgaA bound to agropinic acid at 1.65 Å resolution defines a different agropinic acid-binding signature. Our work highlights the structural and functional characteristics of two efficient agropinic acid assimilation pathways, of which one is also involved in agropine assimilation.
Up-regulated ferritin in periodontitis promotes inflammatory cytokine expression in human periodontal ligament cells through transferrin receptor via ERK/P38 MAPK pathways
Authors: Huang Wenxue , Zhan Yalin , Zheng Yunfei , Han Ye , Hu Wenjie , Hou Jianxia 
Published: December 2018

Abstract
Objective: Ferritin, an iron-binding protein, is ubiquitous and highly conserved; it plays a crucial role in inflammation, which is the main symptom of periodontitis. Full-length cDNA library analyses have demonstrated abundant expression of ferritin in human periodontal ligament. The aims of the present study were to explore how ferritin is regulated by local inflammation, and to investigate its functions and mechanisms of action in the process of periodontitis. Methods: Human gingival tissues were collected from periodontitis patients and healthy individuals. Experimental periodontitis was induced by ligature of second molars in mice. The expression of ferritin light polypeptide (FTL) and ferritin heavy polypeptide (FTH) were assessed by immunohistochemistry. Meanwhile, after stimulating human periodontal ligament cells (HPDLCs) with P. gingivalis-lipopolysaccharide (LPS), interleukin (IL)-6, and tumor necrosis factor-α (TNF-α), the expression of FTH and FTL were measured. Then, IL-6 and IL-8 were measured after incubation with different concentrations of apoferritin (iron-free ferritin) and several intracellular signaling pathway inhibitors, or after knockdown of the transferrin receptor. Results: Both FTH and FTL were substantially higher in inflamed periodontal tissues than in healthy tissues. The location of the elevated expression correlated well with the extent of inflammatory infiltration. Moreover, expression of FTH and FTL were enhanced after stimulation with P. gingivalis-LPS, IL-6, TNF-α. Apoferritin induced the production of IL-6 and IL-8 in a dose-dependent manner partly through binding to the transferrin receptor and activating ERK/P38 signaling pathways in HPDLCs. Conclusions: Ferritin is up-regulated by inflammation and exhibits cytokine-like activity in HPDLCs inducing a signaling cascade that promotes expression of pro-inflammatory cytokines associated with periodontitis.
Technology of production of polystyrene concrete using solar energy
Authors: Aruova Lyazat , Dauzhanov Nabi , Ospanova Zhumabeke , Toleubayeva Shamshygaim , Utkelbaeva Aizhan 
Published: December 2018

The energy of solar radiation is a powerful energy reserve at the surface of the globe which is about twenty billion kW. This amount of energy is more than 100 times greater than the amount of necessary energy for the whole planet; besides the usage of this powerful energy radiator is not associated with polluting substances that pollute the planet. The usage of solar energy nowadays is very important, as the problem of using traditional energy resources is especially acute, because of their irreplaceability and increase in their cost.
At the plants of the Republic of Kazakhstan for the industrial production of building materials today, a trend is outlined for the use of non-traditional types of energy, and mainly solar energy at the stage of heat treatment, where steam heating was traditionally used.
In these researches, development in the direction of temperature treatment of polystyrene concrete was considered. The purpose of the research is the development and practical implementation of the technology of production of polystyrene using solar energy. The results of the conducted researches confirmed that the usage of solar thermal treatment methods for the thermal treatment of polystyrene concrete is effective in weather conditions for the southern regions of the Republic of Kazakhstan which refers to areas with dry and hot climatic conditions. Detailed studies of polystyrene concrete under high-temperature weather conditions have been carried out and introduced into production. The usage of heliotechnology for the production of polystyrene concrete improves the quality of manufactured products, also makes it possible to reduce the energy costs of traditional energy covered by the use of solar energy.
Self-compacting concrete made with the use of local raw materials and industrial wastes
Authors: Endzhievskaya Irina , Shvaenko Dmitriy , Andriyanova Ksenya 
Published: December 2018

The subject matter of the research: fine-dispersed mineral ad-ditives based on raw materials and industrial wastes for the production of self-compacting concrete with prescribed high physical and mechanical characteristics, the use of which will be economically more justified by re-ducing energy consumption, evaluating their contact with superplasticizers.
The aim: the analysis of mineral additives based on local raw materials and industrial wastes combined with a superplasticizer for the production of self-compacting concrete with high physical and mechanical properties.
Materials and methods: scanning electron microscope JEOL JSM-6490 LV, X-ray fluorescence spectrometer for elemental analysis ARL OPTIM, X, ThermoTehno, Switzerland; gas analyzer Gank 4. The parameters to study are as follows: sedimentative and chemical composition of mineral additives, molding properties of a concrete mixture, mechanical properties of concrete.
The result: mineral additives with the use of local raw materials and in-dustrial wastes have been analyzed, optimal costs have been selected for the optimal hydration reaction behavior and the formation of a denser structure of self-compacting concrete.
Conclusions: studies of finely dispersed mineral additives in combination with a superplasticizer have been carried out in order to obtain self-compacting concrete with specified high physical and mechanical proper-ties.
Thermodynamic evaluation using the law of mass action under consideration of the activity coefficients in the system NdCl3-HCl (or NaOH)-H2O-DEHPA-kerosene
Authors: Scharf Christiane , Ditze André 
Published: December 2018

For the recovery of neodymium, an important rare earth metal, solvent extraction using DEHPA as extractant is a possible process for winning and recycling. A preceding study by the authors has provided extensive experimental data of the system neodymium-chloride-hydrochloric acid (or sodium hydroxide)-water-di-(2-ethylhexyl)phosphoric acid (DEHPA)-kerosene. It was found that the description of the reaction Nd3++3(DEHPA)2 ⇄ Nd(DEHP‧DEHPA)3+3H+ by an ideal mass action law is only partly satisfactory. This article investigates the contribution of several parameters to non-ideality. On this basis, expressions for activity coefficients of neodymium in the aqueous phase as well as DEHPA and neodymium in the organic phase are derived. The resulting equations are shown to represent the system with considerably better accuracy than previously possible.
Anxiety in Children and Adolescents with Epilepsy
Authors: Walsh Kelda , Dunn David 
Published: December 2018

AbstractAnxiety is a common comorbidity in children with epilepsy, though often overlooked and undertreated. Fear and worry are common reactions of children with epilepsy and their parents. Risk factors are multiple and include demographical, epilepsy-related, genetic, and family variables. Anxiety negatively affects health-related quality of life (QOL) and may contribute to poor seizure control. Appropriate treatment of anxiety in children with epilepsy should follow practice guidelines developed for treatment of anxiety in children without epilepsy and consist of education, counseling, and potentially psychopharmacology.
High-capacity preconscious processing in concurrent groupings of colored dots
Authors: Sun Peng , Chubb Charles , Wright Charles E. , Sperling George 
Published: December 2018

Significance
A critical visual process is segmenting a scene into objects to be processed (foreground) and the remainder (background). Humans are extraordinarily good at segmentation, but how they accomplish this still is not well understood. An important component process in segmentation is grouping by similarity, for example, by color, shape, size, etc., thereby organizing visual information into coherent chunks for subsequent stages in object recognition. That our subjects can also group dissimilar items shows that the grouping process itself is much more complex than previously believed. Furthermore, we present a fully quantitative account of the inclusiveness/exclusiveness of the grouping process and of its extraordinary perceptual capacity. The amount of information preconsciously utilized to form a group is many times greater than is consciously available.
Application of bioindicator film from tapioca/agar/mulberry (Morus alba L.) to detect sausage spoilage
Authors: Wardana Ata Aditya , Wiramukti Adyafahmi , Widyaningsih Tri Dewanti 
Published: December 2018

Abstract
In this study, development of a bioindicator film to detect sausage spoilage has been evaluated. The objectives of this research were to develop a bioindicator film from blended tapioca, agar, and mulberry juice and to asses its performance in detecting sausage spoilage. Different concentration of agar (3, 5, 7% by weight of tapioca) and crude extract of anthocyanin (CEA) from mulberry (10, 15, 20% by total volume of suspension) were formulated in this experiment beside glycerol as the plasticizer. The screening of the best bioindicator film was determined statistically according to multiple criteria decision making method prior sausages wrapping. Selected biofilm, 2% tapioca + 7% agar + 20% CEA, was able to detect an increase of microbial counts and pH variations as a consequent of sausage spoilage exhibited by color alteration of biofilm from dark red at 0 h to red-green at 24 h, and more greenness at 48 and 72h.
Australian lessons for developing and testing a culturally inclusive health promotion campaign
Authors: Telenta Joanne , Jones Sandra C , Francis Kate L , Polonsky Michael J , Beard Joshua , Renzaho Andre M N 
Published: December 2018

AbstractThe purpose of the study was to develop and test culturally appropriate health promotion materials that were seen to be socially inclusive in regard to blood donation within the Australian-African community. Materials were produced in multiple languages (English, Arabic, Swahili and Kirundi) and were initially developed based on previous pilot data, with feedback from the project partner (Australian Red Cross Blood Service) and the African community. Seven formative focus groups with 62 participants were then conducted to ensure the materials would be effective, credible and culturally acceptable to the target audience, including preferred messages, taglines and images. The response confirmed that quotes and images from community members (as opposed to actors) were critical to ensure messages were engaging and believable, and had meaningful taglines that were perceived to be authentic. The refined materials were then used in a community intervention study. The evaluation included an assessment of respondents’ views of the messages post-intervention. Of the 281 African migrants who saw the campaign materials during the intervention period, the majority (75.8%) strongly agreed that the materials made them feel part of the wider Australian community. These results suggest that engagement in developmental activities with targeted communities is important for creating positively viewed culturally targeted public health campaigns. A six-step process is suggested that could be used by other organizations to ensure that messages are acceptable to targeted migrant communities.
Clipping of Basilar Perforator Pure Arterial Malformation Aneurysm: 2-Dimensional Operative Video
Authors: Munich Stephan A , Brunet Marie Christine , Starke Robert M , Morcos Jacques J 
Published: December 2018

Abstract
Pure arterial malformations are rarely-encountered intracranial lesions, often mistaken for arteriovenous malformations. A minority of these lesions may harbor associated aneurysms. In a recent series of 12 patients with pure arterial malformations, 3 patients had associated aneurysms.
1
As the authors describe, the presentation and natural history of pure arterial malformations generally are considered benign. In over 85% of cases reported in the literature, they are discovered incidentally and in cases with documented follow-up the angio-architecture tends to remain stable.
1

However, here we present the case of an aneurysm associated with a pure arterial malformation managed with microsurgical clipping. The patient presented to us with the development of hemorrhage within and/or around the lesion and the development of a partial CN III palsy. Using a cranio-orbital approach, we successfully performed clipping of the offending vessel in the region of the basilar apex. Critical to the successful treatment of this lesion were: the correct identification of the offending vessel, recognition of the presence of perforating arteries, and clipping of the offending artery distal to the origin of the perforating arteries. This case represents a rare instance of a symptomatic pure arterial malformation with associated aneurysm.
Verbal consent was provided by the patient for reproduction and publication of her case.
The Matter of Timbre
Authors: Villegas Vélez Daniel 
Published: December 2018

Abstract
This chapter offers a critique of traditional Western accounts of timbre to propose that, instead of a secondary parameter subordinated to pitch and rhythm, timbre is a general category—a condition of possibility for listening—that depends on embodied perception and makes difference audible. The chapter draws from phenomenology as well as psychoacoustic and ethnographic research, focusing on case studies ranging from Fatima Al Qadiri to Julius Eastman, alongside ethnographic analyses of Barundi Whispered Inanga, sonic encounters in nineteenth-century Colombia, and readings of Jean-Jacques Rousseau, Eduard Hanslick, and Guido Adler, to provide a broader account of timbre that encompasses the imbrication of acoustic components with memory, affect, and language. In this respect, timbre emerges as an important critical and musicological category that helps us address issues of embodied difference and culturally dependent forms of listening, while reassessing the prominence of Eurocentric conceptions of musical values.
Reproduction and Crisis in Capitalist Economies
Authors: Basu Deepankar 
Published: December 2018

Abstract
An economic crisis in capitalism is a deep and prolonged interruption of the economy-wide circuit of capital. Crises emerge from within the logic of capitalism’s operation, and are manifestations of the inherently contradictory process of capital accumulation. The Marxist tradition conceptualizes two types of crisis tendencies in capitalism: a crisis of deficient surplus value and a crisis of excess surplus value. Two mechanisms that become important in crises of deficient surplus value are the rising organic composition of capital and the profit squeeze: two mechanisms that are salient in crises of excess surplus value are problems of insufficient aggregate demand and increased financial fragility. This chapter offers a synthetic and synoptic account of the Marxist literature on capitalist crisis.
Metabolic Rifts and the Ecological Crisis
Authors: Clark Brett , Foster John Bellamy , Longo Stefano B. 
Published: December 2018

Abstract
In analyzing the relations between human societies and the larger biophysical world, Karl Marx employed a dialectical triadic scheme of “the universal metabolism of nature,” the “social metabolism,” and the metabolic rift. He incorporated this metabolic approach within his critique of political economy, allowing him to assess the historical interchanges and interpenetrations of society and ecological systems. Given its endless pursuit of accumulation, capitalism imposes its demands on nature, increasing pressures on ecological systems and the production of wastes. It generates distinct metabolic rifts (ruptures) in natural cycles and processes. Marx specifically developed this approach in his critique of capitalist agriculture, with regard to how this system created an ecological rift in the soil nutrient cycle. Contemporary scholarship has drawn upon this work to examine a broad array of ecological contradictions, which are culminating in an ecological crisis.
Sex Discrimination and the Transformation of U.S. Education
Authors: Buzuvis Erin E. 
Published: December 2018

Abstract
This chapter highlights the role of Title IX of the Education Amendments Act of 1972 and the U.S. Constitution’s Equal Protection Clause of the Fourteenth Amendment in transforming the gendered landscape of U.S. education. After first providing an overview of these two sources of law, the chapter examines the role they have played in challenging sex-based designations in admissions and in the classroom, in promoting equal opportunity and access to school-sponsored athletics, in challenging sexual harassment and other sexual misconduct, in reducing barriers to LGBT students, and in promoting equal opportunity for students who are pregnant. Sections addressing each one of these topics will also note limitations and shortcomings of the law’s approach to these issues, as there is still more work to do to fully realize sex equality in education. While the law has not cured all the problems of sex discrimination education, owing to limitations in its scope, as well as enforceability, it has proven to be a powerful source of societal norms and expectations, which themselves operate to motivate compliance and beyond.
Unifying the Midbrain
Authors: Rees Adrian , Orton Llwyd D. 
Published: December 2018

Abstract
Commissural fibres interconnecting the two sides of the brain are found at several points along the auditory pathway, thus suggesting their fundamental importance for the analysis of sound. This chapter presents an overview of what is currently known about the anatomy, physiology, and behavioral influences of the commissure of the inferior colliculus (CoIC)—the most prominent brainstem auditory commissure—that reciprocally interconnects the principal nuclei of the auditory midbrain, the inferior colliculi (IC). The primary contribution to the CoIC originates from neurons projecting from one inferior colliculus to the other, with the dorsal cortex and central nucleus providing the most extensive connections. In addition, many ascending and descending auditory centers send projections to the IC via the CoIC, together with diverse sources located outside the classically defined auditory pathway. The degree of interconnection between the two ICs suggests they function as a single entity. Recent in vivo evidence has established that CoIC projections modulate the neural representation of sound frequency, level, and location in the IC, thus indicating an important role for the CoIC in auditory processing. However, there is limited evidence for the influence of the CoIC on auditory behavior. This, together with the diversity of sources projecting via the CoIC, suggest unknown roles that warrant further exploration.
The Medial Superior Olivary Nucleus
Authors: Grothe Benedikt , Leibold Christian , Pecka Michael 
Published: December 2018

Abstract
It doesn’t get any more precise than this: Neurons in the medial superior olive (MSO) in many mammals, including humans, are sensitive to temporal differences between their synaptic inputs of only a few microseconds. These neurons are the basis for our ability to resolve even a 5-μs disparity in the time of arrival of a sound at each ear. This capacity enables humans to discriminate between temporally overlapping sounds based on spatial segregation, as for instance, at a cocktail party or a poster session at a scientific conference. This chapter aims at providing a comprehensive summary on the current state of research regarding the MSO, ranging from cellular and circuit anatomy to subcellular and channel physiology to spatial coding and perception. Consequently, the chapter is subdivided according to these thematic aspects. Nonetheless, while such subdivisions are helpful for providing structure to the reader, they can also convey the inter-dependencies between these topics: for example, when studying the spatial sensitivity of MSO neurons on the mechanistic level, it is crucial to also consider its anatomical specializations (on the subcellular and circuit level), as well as corresponding perceptional phenomena. Finally, the chapter suggests a complete picture of the MSO only emerges by including evolutionary considerations, that is, the phylogenetic origin of the many fascinating specializations that can be observed within the MSO circuit.