bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atomic model of microtubule-bound tau
Authors: Kellogg Elizabeth H. , Hejab Nisreen M.A. , Poepsel Simon , Downing Kenneth H. , DiMaio Frank , Nogales Eva 
Published: February 2018

AbstractTau is a developmentally regulated protein found in axons, whose physiological role is to stabilize and bundle microtubules (MTs). Hyper-phosphorylation of tau is thought to cause its detachment from MTs and subsequent aggregation into pathological fibrils that have been implicated in Alzheimer’s disease pathogenesis. Despite its known MT binding role, there is no consensus regarding which tau residues are crucial for tau-MT interactions, where on the MT tau binds, and how binding results in MT stabilization. We have used cryo-EM to visualize the interaction of different tau constructs with MTs at high resolution (3.2-4.8 Å) and used computational approaches to generate atomic models of tau-tubulin interactions. Our work shows that the highly conserved tubulin-binding repeats within tau adopt very similar structures in their interactions with the MT. Each tau repeat binds the MT exterior and adopts an extended structure along the crest of the protofilament (PF), interacting with both α- and β-tubulin, thus stabilizing the interface between tubulin dimers. Our structures agree with and explain previous biochemical data concerning the effect of phosphorylation on MT affinity and lead to a model in which tau repeats bind in tandem along a PF, tethering together tubulin dimers and stabilizing longitudinal polymerization interfaces. These structural findings could establish a basis of future treatments aiming at the selective stabilization of tau-MT interactions.
Inferring Cancer Progression from Single-cell Sequencing while Allowing Mutation Losses
Authors: Ciccolella Simone , Gomez Mauricio Soto , Patterson Murray , Vedova Gianluca Della , Hajirasouliha Iman , Bonizzoni Paola 
Published: February 2018

AbstractMotivationIn recent years, the well-known Infinite Sites Assumption (ISA) has been a fundamental feature of computational methods devised for reconstructing tumor phylogenies and inferring cancer progressions seen as an accumulation of mutations. However, recent studies (Kuiperset al., 2017) leveraging Single-cell Sequencing (SCS) techniques have shown evidence of the widespread recurrence and, especially, loss of mutations in several tumor samples. Still, established methods that can infer phylogenies with mutation losses are however lacking.ResultsWe present theSASC(Simulated Annealing Single-Cell inference) tool which is a new and robust approach based on simulated annealing for the inference of cancer progression from SCS data. More precisely, we introduce a simple extension of the model of evolution where mutations are only accumulated, by allowing also a limited amount of back mutations in the evolutionary history of the tumor: the Dollo-kmodel. We demonstrate thatSASCachieves high levels of accuracy when tested on both simulated and real data sets and in comparison with some other available methods.AvailabilityThe Simulated Annealing Single-cell inference (SASC) tool is open source and available athttps://github.com/sciccolella/sasc.Contacts.ciccolella@campus.unimib.it
Abstract concept learning in a simple neural network inspired by the insect brain
Authors: Cope Alex J. , Vasilaki Eleni , Minors Dorian , Sabo Chelsea , Marshall James A.R. , Barron Andrew B. 
Published: February 2018

AbstractThe capacity to learn abstract concepts such as ‘sameness’ and ‘difference’ is considered a higher-order cognitive function, typically thought to be dependent on top-down neocortical processing. It is therefore surprising that honey bees apparantly have this capacity. Here we report a model of the structures of the honey bee brain that can learn same-ness and difference, as well as a range of complex and simple associative learning tasks. Our model is constrained by the known connections and properties of the mushroom body, including the protocerebral tract, and provides a good fit to the learning rates and performances of real bees in all tasks, including learning sameness and difference. The model proposes a novel mechanism for learning the abstract concepts of ‘sameness’ and ‘difference’ that is compatible with the insect brain, and is not dependent on top-down or executive control processing.
Developing an automated iterative near-term forecasting system for an ecological study
Authors: White Ethan P. , Yenni Glenda M. , Taylor Shawn D. , Christensen Erica M. , Bledsoe Ellen K. , Simonis Juniper L. , Ernest S. K. Morgan 
Published: February 2018

AbstractMost forecasts for the future state of ecological systems are conducted once and never updated or assessed. As a result, many available ecological forecasts are not based on the most up-to-date data, and the scientific progress of ecological forecasting models is slowed by a lack of feedback on how well the forecasts perform.Iterative near-term ecological forecasting involves repeated daily to annual scale forecasts of an ecological system as new data becomes available and regular assessment of the resulting forecasts. We demonstrate how automated iterative near-term forecasting systems for ecology can be constructed by building one to conduct monthly forecasts of rodent abundances at the Portal Project, a long-term study with over 40 years of monthly data. This system automates most aspects of the six stages of converting raw data into new forecasts: data collection, data sharing, data manipulation, modeling and forecasting, archiving, and presentation of the forecasts.The forecasting system uses R code for working with data, fitting models, making forecasts, and archiving and presenting these forecasts. The resulting pipeline is automated using continuous integration (a software development tool) to run the entire pipeline once a week. The cyberinfrastructure is designed for long-term maintainability and to allow the easy addition of new models. Constructing this forecasting system required a team with expertise ranging from field site experience to software development.Automated near-term iterative forecasting systems will allow the science of ecological forecasting to advance more rapidly and provide the most up-to-date forecasts possible for conservation and management. These forecasting systems will also accelerate basic science by allowing new models of natural systems to be quickly implemented and compared to existing models. Using existing technology, and teams with diverse skill sets, it is possible for ecologists to build automated forecasting systems and use them to advance our understanding of natural systems.
CSR and consumer behavioral responses: the role of customer-company identification
Authors: Fatma Mobin , Khan Imran , Rahman Zillur 
Published: February 2018

PurposeThe purpose of this paper is to examine the influence of perceived CSR and its influence on customer satisfaction and loyalty in the hotel industry.Design/methodology/approachPersonal surveys of hotel guests were carried out in three metropolitan cities of India. The survey resulted in 327 valid responses which were further analyzed. To test the proposed model, structural equation modeling was applied.FindingsThe findings show that consumer perception of CSR activities positively influences consumer identification with the company, and identification positively results in customer satisfaction and loyalty.Research limitations/implicationsFindings of the study have important implications for hospitality companies as they suggest that hotel managers should invest more in socially responsible initiatives since consumers tend to support those firms that are perceived as socially responsible by developing a sense of loyalty towards them.Originality/valueThis study provides a comprehensive framework that integrates social identity and social exchange perspectives towards building customer satisfaction and loyalty.
Deconstructing the reinvention of operations management
Authors: Wilson James M. 
Published: February 2018

Purpose
The purpose is to provide an intellectual history of Operations Management, particularly noting recent developments and its underlying continuity with earlier systems and thinking. Operations Management as a discipline identifies its “modern” incarnation as dating from the 1960s when it became more rigorous and managerially focused. This re-invention constructed a “narrative” that the profession still follows, yet a critical perspective reveals significant, though under-appreciated continuity with earlier theory and practice.

Design/methodology/approach
This paper presents a comprehensive literature review and comparative analysis of historic developments in management and academia.

Findings
In the early 1900s, F. W. Taylor’s Shop Management established Operation Management, but its main component, Scientific Management, had stagnated by the 1950s. At that point, the rise of Management Science both reinvigorated Operations Management and threatened it with a competing new discipline. To compete Operations Management then modernized by redefining itself, reasserting its interest in several areas and co-opting Operational Research tools for those. It also contracted, withdrawing from areas considered vocational, or more suited to Industrial Engineering.

Research limitations/implications
This historical overview shows the critical importance of drawing research agenda from practical managerial concerns.

Practical implications
Practitioners benefit from the intellectual rigor that academics provide and a historical perspective shows that the relationship has been mutually beneficial.

Social implications
The disciplines of Operations Management, Operations Research and Industrial Engineering are complementary and competitive in addressing many problems that transcend their boundaries, and use common ideas and techniques. The demands of “academic rigor” have had a deleterious effect on the practical managerial relevance of these disciplines.

Originality/value
A long-term, cross-disciplinary perspective provides a unique understanding of the research interests and practical orientations of these disciplines.
The Thatcher government and (de)regulation: modularisation of individual personal pensions
Authors: Burton Nicholas 
Published: February 2018

PurposeThe (de)regulation agenda of the Conservative government, led by Margaret Thatcher, elected in 1979 is an important change point that has attracted only limited attention from management and historical research scholars. Thus, how (de)regulation in this era influenced the evolution of product design remains ripe for exploration. The purpose of this paper is to examine the UK individual personal pensions product market between the mid-1980s and mid-1990s to examine the relationship between (de)regulation – an industry-level factor – and its impact on architectural choices of product design – a product-level factor.Design/methodology/approachA retrospective, oral history research design with 31 senior managers in product development firms with first-hand experience of the change period was adopted.FindingsFindings indicate that the (de)regulation reforms and the context of the financialisation of product markets came to define how products were then designed, evolving product design from non-modular to near-modular, a trajectory that arguably continues until the present day.Originality/valueThe main contribution lies in examining the role of (de)regulation and financialisation as modularisation processes. The increasing modularisation of individual personal pension product design between the mid-1980s and mid-1990s provides further support for the body of scholarly work on modularisation processes and their relationship with industry change.
The Free-Standing Company: a “zombie” theory of international business history?
Authors: Mollan Simon 
Published: February 2018

PurposeThe purpose of this paper is to decompose the historical and conceptual basis of the Free-Standing Company (FSC) in international business history. This is used to critique the FSC concept. The paper then provides a new framework to explain the lifecycle of these firms in a theoretically sensitive way.Design/methodology/approachThe paper is conceptual. The argument is developed through a critical reading of the existing literature.FindingsThe central argument presented is that the FSC concept is ahistorical and cannot fully explain the firms it considers over time. An alternative approach is proposed.Research limitations/implicationsThe paper does not present new (archival) historical evidence.Originality/valueThe central contribution/ambition of the paper is to advance the theoretical understanding of international firms of considerable historical importance. The ambition of the paper is to help renew research into this important historical organizational form that speaks directly to the ability of historical research to help advance international business theory.
Shadow hybridity and the institutional logic of professional sport
Authors: Gillett Alex G. , Tennent Kevin D. 
Published: February 2018

PurposeExisting studies of the finance of English Association Football (soccer) have tended to focus on the sport’s early years, or on the post-1992 Premiership era. The authors examine a case from the turbulent 1980s charting the struggle for economic survival of one club in a rapidly changing financial, economic, political and demographic landscape. The purpose of this paper is to examine not only the financial management of a football club during this time, but also the interventionist role of the local authority during this turbulent period.Design/methodology/approachThe authors investigate the financial difficulties of a sport business, Middlesbrough Football and Athletic Company Limited, examining the broader economic context, drawing on unseen archival sources dating from the 1980s to analyze the relationship between club, local and national government and the regional economy.FindingsThey not only examine the financial management of the football club but also analyse the interventionist role of the local authority in supporting the club which had symbolic value for the local community.Practical implicationsThis paper is relevant to policymakers interested in the provision of local sports facilities and the links between elite sport and participation.Originality/valueThe authors show that professional sports clubs are driven by a different institutional logic to state organizations and the findings enable them to define these differences, thereby refining Thornton et al.’s (2012) typology of institutional orders. Furthermore, the case study highlights practices involving informal partnership between state and sport that the authors label as shadow hybridity.
Self-other agreement on transformational leadership and subordinates’ assessment of supervisor’s performance
Authors: Ertürk Alper , Van den Broeck Herman , Verbrigghe Jasmijn 
Published: February 2018

Purpose
Given the importance of the extent to which supervisors and their subordinates agree in their assessment of supervisors’ leadership, the purpose of this paper is to investigate the possible relationship between self-other agreement on supervisors’ transformational leadership and subordinates’ perceptions of supervisors’ in-role and extra-role performance, through the mediating role of leader-member exchange.

Design/methodology/approach
Self-other agreement was conceptualized as the degree of congruence between supervisors’ self-assessment and subordinates’ assessment of supervisors’ transformational leadership. Data were collected from 36 supervisors and 189 of their subordinates. Cross-level polynomial regressions and surface response analysis were used to analyze the hypothesized relationships.

Findings
Statistical analyses revealed that self-other agreement on idealized influence and individual support are positively associated with subordinates’ perception of leader-member exchange, and in turn leader member fully mediates the relationship between self-other agreement and subordinates’ perceptions regarding their supervisors’ performance. Results from polynomial analyses indicate that subordinates’ ratings of leader-member exchange would be highest for underestimator, second for in-agreement/good supervisors, third for in-agreement/poor and lowest for overestimator supervisors both for the idealized influence and individual support.

Originality/value
This is one of the pioneer studies investigating the potential relationship between self-other agreement on supervisors’ transformational leadership and the subordinates’ perceptions on their supervisors’ performance through social exchange. Since researchers have paid scant attention to intervening mechanisms, this study aims to extend previous research in the literature by investigating those associations through the mediating effect of leader-member exchange.
Clinical guidelines for prevention and management of preterm birth: a systematic review
Authors: Medley N , Poljak B , Mammarella S , Alfirevic Z 
Published: February 2018

BackgroundClinical practice guidelines (CPG) endorse multiple strategies to prevent or manage preterm birth (PTB).ObjectivesTo summarise CPG recommendations for PTB and identify areas of international consensus.Search strategyIn May 2017 we searched for all CPG relevant to PTB without language restrictions.Selection criteriaCPG were eligible if the following criteria were met: (1) the guideline was published or current from June 2013; (2) the guideline recommended practices for the prevention or management of PTB relevant to our prespecified clinical questions for screening, medications or surgery and other interventions; (3) publications on methods of guideline development for eligible CPG were included to enable quality assessment.Data collection and analysisTwo authors classified CPG recommendations relevant to prespecified clinical questions. When more than 70% of CPGs reporting on a topic recommended or rejected an intervention, we regarded this as consensus. We summarised recommendations in tables.Main resultsWe identified 49 guidelines from 16 guideline developers. We found consensus for several clinical practices: cervical length screening for high‐risk women; short‐term tocolysis; steroids for fetal lung maturation; and magnesium sulphate for fetal neuroprotection. We found discrepant recommendations for progesterone and fibronectin. No guideline identified an effective strategy for women with multiple pregnancy.ConclusionsWe identified interventions for which there is an international consensus on benefit for PTB. Systematic reviews of CPG using standardised methodology will help avoid duplication and target scarce resources for guideline developers globally.Tweetable abstractInternational clinical guidelines agree on the benefits and harmful effects of several important interventions to prevent preterm birth.
A Comparison Among Three Multiplex Y‐STR Profiling Kits for Sexual Assault Cases
Authors: Ferreira‐Silva Benedita , Fonseca‐Cardoso Margarida , Porto Maria João , Magalhães Teresa , Cainé Laura 
Published: February 2018

AbstractBiological evidence of sexual assault is one of the most difficult sample types to analyze in forensic laboratories. Y‐STR markers are thus a valuable tool for analyzing these samples. The aim of this project was to compare three Y‐STR commercial kits by analyzing their amplification performance on casework samples. Overall, 247 trace samples were analyzed with a Yfiler® Plus PCR Amplification Kit (Applied Biosystems), PowerPlex® Y23 (Promega®) System and AmpFLSTR® Yfiler™ PCR Amplification Kit (Applied Biosystems). Comparing the amplification performance of the three kits, the first two were significantly more sensitive than the latter (p < 0.001). For samples, with a male DNA quantity less than 0.5 ng, the PowerPlex Y23® kit was the most sensitive and best performing kit, followed by the Yfiler® Plus kit (p = 0.009). In conclusion, the Yfiler® Plus and PowerPlex Y‐23® kits are viable alternatives to older kits for samples with low amounts of male DNA.
Dielectric properties for non‐invasive detection of normal, benign, and malignant breast tissues using microwave theories
Authors: Cheng Yiou , Fu Minghuan 
Published: February 2018

BackgroundDespite the high incidence of breast cancer worldwide, methods for early non‐invasive diagnosis and sensitive and specific prognostic evaluation remain difficult. In this study, we investigated microwave parameters as a potential non‐invasive approach to detect breast cancer.MethodsSamples of freshly excised breast tissues (n = 509) from 98 patients were identified as normal, benign tumor, or malignant cancer via histology. Further samples were prepared and the microwave effective dielectric permittivity and effective conductivity were measured every 0.0375 GHz from 0.5 GHz to 8 GHz. These parameters were compared among the breast tissue types.ResultsThe effective relative permittivity and effective conductivity at each frequency was significantly higher in breast cancer tissues compared with benign tumors, which in turn was significantly higher than in normal breast tissue. The standard deviation of each parameter was narrowest at ~2.5 GHz in both normal and malignant breast tissues.ConclusionsThe effective dielectric permittivity and effective conductivity, measured via microwave technology, could differentiate breast cancer from normal and benign tumor tissues.
Auditors' Use of Formal Advice from Internal Firm Subject Matter Experts: The Impact of Advice Quality and Advice Awareness on Auditors' Judgments
Authors: Wright Nicole S. , Bhattacharjee Sudip 
Published: February 2018

ABSTRACTWhen subject matter experts are consulted during an audit, the quality of the expert's advice depends upon their ability to fully understand and incorporate client‐specific facts into their advice. Public Company Accounting Oversight Board (PCAOB) inspection reports suggest that auditors are neglecting to perform the required work to assess the quality of experts' recommendations. This study examines how characteristics of the audit, notably staffing decisions, can impede auditors' ability to discern advice quality. In an experiment, we examine how receiving advice of different levels of quality (lower or higher incorporation of relevant client facts) and awareness at the planning stage of the use of a subject matter expert (a priori aware or unaware) impacts auditors' effort, utilization of the advice, and judgment accuracy. We find that awareness of an expert being employed led to a social facilitation effect such that auditors who were a priori aware put forth more effort prior to receiving the expert advice and were initially in less agreement with management's aggressive revenue recognition position than auditors who were unaware. Upon receiving the expert advice, auditors who were a priori aware were more accurate than auditors who were unaware. These results should interest both audit regulators and practitioners by demonstrating how the timing and communication of consulting decisions affect auditors' assessments of advice received from subject matter experts.