bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positron Emission Tomography Imaging of [11C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A
Authors: Billington Sarah , Shoner Steven , Lee Scott , Clark‐Snustad Kindra , Pennington Matthew , Lewis David , Muzi Mark , Rene Shirley , Lee Jean , Nguyen Tot Bui , Kumar Vineet , Ishida Kazuya , Chen Laigao , Chu Xiaoyan , Lai Yurong , Salphati Laurent , Hop Cornelis E.C.A. , Xiao Guangqing , Liao Mingxiang , Unadkat Jashvant D. 
Published: May 2019

Using positron emission tomography imaging, we determined the hepatic concentrations and hepatobiliary transport of [11C]rosuvastatin (RSV; i.v. injection) in the absence (n = 6) and presence (n = 4 of 6) of cyclosporin A (CsA; i.v. infusion) following a therapeutic dose of unlabeled RSV (5 mg, p.o.) in healthy human volunteers. The sinusoidal uptake, sinusoidal efflux, and biliary efflux clearance (CL; mL/minute) of [11C]RSV, estimated through compartment modeling were 1,205.6 ± 384.8, 16.2 ± 11.2, and 5.1 ± 1.8, respectively (n = 6). CsA (blood concentration: 2.77 ± 0.24 μM), an organic‐anion‐transporting polypeptide, Na+‐taurocholate cotransporting polypeptide, and breast cancer resistance protein inhibitor increased [11C]RSV systemic blood exposure (45%; P < 0.05), reduced its biliary efflux CL (52%; P < 0.05) and hepatic uptake (25%; P > 0.05) but did not affect its distribution into the kidneys. CsA increased plasma concentrations of coproporphyrin I and III and total bilirubin by 297 ± 69%, 384 ± 102%, and 81 ± 39%, respectively (P < 0.05). These data can be used in the future to verify predictions of hepatic concentrations and hepatobiliary transport of RSV.
Reversible Intercalation of Multivalent Al3+ Ions into Potassium‐Rich Cryptomelane Nanowires for Aqueous Rechargeable Al‐Ion Batteries
Authors: Joseph Jickson , Nerkar Jawahar , Tang Cheng , Du Aijun , O'Mullane Anthony P. , Ostrikov Kostya (Ken) 
Published: May 2019

AbstractThe development of new battery technology that utilizes abundant electrode materials that are environmentally benign is an important area of research. To alleviate the reliance on Li‐ion batteries new energy storage mechanisms are urgently needed. To address these issues, MnO2 nanowires were investigated as a possible electrode material for use in rechargeable Al ion batteries that can operate in aqueous conditions. The use of this type of material and an aqueous electrolyte ensures safe operation as well as easy recycling of spent batteries. A potassium‐rich cryptomelane structure was presented, and a new mechanism of electrochemical energy storage was elucidated based on the intercalation and deintercalation of small‐radius Al3+ ions interchanging with larger K+ ions in the cryptomelane MnO2 nanowires, which was supported by DFT calculations. This first‐time use of a cryptomelane MnO2 cathode for an aqueous Al ion system yielded a discharge capacity of 109 mAh g−1, which indicates the potential commercial viability of rechargeable aqueous Al‐ion batteries.
Deformation ‘boundary front’ movements in subglacial tills—A microsedimentological perspective from till sequences near Pine Point, NWT, Canada
Authors: Menzies John , Paulen Roger C. , Rice Jessey M. , McClenaghan M. Beth , Oviatt Natasha M. , Dhillon Nitasha 
Published: May 2019

AbstractInvestigations of glacial sediment exposures in a former open pit in the Pine Point Mining District, Northwest Territories, reveal evidence of changes in stress magnitude as exhibited by the movement of deformation ‘fronts’ within subglacial tills, as evident through micromorphological analysis. Indications of deformation, driven by stress fluctuations, were observed throughout a set of vertical subglacial till samples associated with the Laurentide Ice Sheet. These tills exhibit multiple sub‐lithofacies variations in concert with marked changes in microshear orientation, which can be directly related to changing stress levels within a subglacial deforming bed. The evidence of changes in till stress conditions is typical of subglacial tills occurring beneath an active temperate ice mass within a soft deforming bed. As differing ‘layers’ of till that form a mosaic‐like pattern become immobilized and ‘detached’ subjacent to the deforming bed sediments, a signature of this action is recorded within the tills as sequences of specific microstructures. These microstructures are part of a spectrum of micro‐forms that develop as consequence of changes in stress, porewater content and clay content within the ‘fault‐gouge’—like environment formed beneath an active temperate ice sheet. A model is developed that uses data from Pit O‐28 demonstrating where deformation ‘boundary front’ evidence in the form of deformation bands has developed as basal driven stress levels have penetrated active deforming sediments. The evidence from Pine Point indicates that till acts as an excellent palaeo‐strain record of past active glacial processes, subglacial basal thermal conditions and sediment mobility.
Co‐activation of SAM and HPA responses to acute stress: A review of the literature and test of differential associations with preadolescents’ internalizing and externalizing
Authors: Wadsworth Martha E. , Broderick Amanda V. , Loughlin‐Presnal John E. , Bendezu Jason J. , Joos Celina M. , Ahlkvist Jarl A. , Perzow Sarah E. D. , McDonald Ashley 
Published: May 2019

AbstractUnderstanding co‐activation patterns of the hypothalamic‐pituitary‐adrenal axis (HPA) and sympathetic adrenal medullary (SAM) during early adolescence may illuminate risk for development of internalizing and externalizing problems. The present study advances empirical work on the topic by examining SAM‐HPA co‐activation during both the reactivity and recovery phases of the stress response following acute stress exposure. Fourth and fifth grade boys and girls (N = 149) provided cortisol and alpha‐amylase via saliva at seven times throughout a 95‐min assessment in which they were administered the modified Trier Social Stress Test. Parents reported on adolescents’ life stress, pubertal development, medication use, and externalizing problems. Adolescents reported their own internalizing symptoms. Multiple linear regressions tested both direct and interactive effects of SAM and HPA reactivity and recovery on internalizing and externalizing problems. Results from these analyses showed that whereas SAM and HPA reactivity interacted to predict internalizing symptoms, it was their interaction during the recovery phase that predicted externalizing. Concurrent high SAM and HPA reactivity scores predicted high levels of internalizing and concurrently low SAM and HPA recovery scores predicted high levels of externalizing. Implications of the findings for further study and clinical application are discussed.
Cellular Automata Modeling of Stem‐Cell‐Driven Development of Tissue in the Nervous System
Authors: Lehotzky Dávid , Zupanc Günther K.H. 
Published: May 2019

AbstractMathematical and computational modeling enables biologists to integrate data from observations and experiments into a theoretical framework. In this review, we describe how developmental processes associated with stem‐cell‐driven growth of tissue in both the embryonic and adult nervous system can be modeled using cellular automata (CA). A cellular automaton is defined by its discrete nature in time, space, and state. The discrete space is represented by a uniform grid or lattice containing agents that interact with other agents within their local neighborhood. This possibility of local interactions of agents makes the cellular automata approach particularly well suited for studying through modeling how complex patterns at the tissue level emerge from fundamental developmental processes (such as proliferation, migration, differentiation, and death) at the single‐cell level. As part of this review, we provide a primer for how to define biologically inspired rules governing these processes so that they can be implemented into a CA model. We then demonstrate the power of the CA approach by presenting simulations (in the form of figures and movies) based on building models of three developmental systems: the formation of the enteric nervous system through invasion by neural crest cells; the growth of normal and tumorous neurospheres induced by proliferation of adult neural stem/progenitor cells; and the neural fate specification through lateral inhibition of embryonic stem cells in the neurogenic region of Drosophila.
Safety and efficacy of antihyperglycaemic agents in diabetic kidney disease
Authors: Niezen Sebastian , Diaz del Castillo Humberto , Mendez Castaner Lumen A. , Fornoni Alessia 
Published: May 2019

AbstractDiabetic kidney disease (DKD) is the major contributor to the mortality and the financial burden of diabetes, accounting for approximately 50% of the cases of end‐stage renal disease (ESRD) in the developed world. Several studies have already demonstrated that achieving blood pressure targets in DKD with agents blocking the renin‐angiotensin system confer superior renoprotection when compared to other agents. However, the effects on renal outcomes of antihyperglycaemic agents in these patients have not been reported or studied broadly until recent years. The intent of this article is to review the available data on safety, efficacy, impact on renal outcomes and pathophysiology implications of the most utilized antihyperglycaemic agents in DKD/ESRD.
Effect of Pollution on the Quality of Olive Oils from Trees Grown Near a Phosphoric Acid Factory
Authors: Rekik Ons , Ben Mansour Amir , Jabeur Hazem , Rodriguez Gutierrez Guillermo , Bouaziz Mohamed 
Published: May 2019

Given the importance of olive oil as a food product worldwide and given the exposure of many productive olive orchards to many pollution sources, this work is a contribution to the clarification of atmospheric metal pollution effects on the quality of olive oil and its possible toxicity for human beings. This work is carried out on olive orchards (Olea europaea L., cv. Chemlali) situated in a polluted region close to a fertilizer factory and in a controlled, unpolluted area, managed with comparable cultivation techniques during two successive years (2015/2016 and 2016/2017). Pollution negatively affects the oxidative stability and nutritional value of olive oil, especially by decreasing the contents of antioxidant compounds and the fatty acid composition. Atmospheric metals are confirmed to have a negative effect on olive oil chemicals; oils show a disruption of their squalene, tocopherols, and triglyceride composition in comparison with control oils.Practical Applications: This study is carried out in two olive orchards (Olea europaea L., cv. Chemlali) located in a polluted area near a fertilizer factory and in a control unpolluted site, managed with similar cultivation techniques. The aim is to investigate the physiological and biochemical responses of polluted oils (PO), exposed to atmospheric metal contamination as compared to control oils (CO). The results of this study emanate from the accidental exposure to contamination sources, such as the direct contact of olives, with an elevated polluted environment that might be made more severe by gaseous air pollutants emitted by the factory. Then, air contamination avoidance from factories should be examined together with any possible probable methodologies to decrease plant tissue contamination.The SIAPE is the main pollution source in Sfax city. Vegetation developed around the city is continuously exposed to air pollution. Therefore, olive fruits are contaminated by the chemical pollution which affects the quality of olive oils.
Rat Organic Anion Transport Protein 1A1 Interacts Directly With Organic Anion Transport Protein 1A4 Facilitating Its Maturation and Trafficking to the Hepatocyte Plasma Membrane
Authors: Wang Pijun , Wang Wen‐Jun , Choi‐Nurvitadhi Jo , Lescaille Yaniuska , Murray John W. , Wolkoff Allan W. 
Published: May 2019

Organic anion transport proteins (OATPs) on the basolateral surface of hepatocytes mediate uptake of a number of drugs and endogenous compounds. Previous studies showed that rat OATP1A1 (rOATP1A1) has a postsynaptic density protein, drosophila disc large tumor suppressor, zonula occludens‐1 protein (PDZ) consensus binding motif at its C‐terminus and binds to PDZ domain containing 1 (PDZK1), which is required for its cell‐surface localization. PDZK1 associates with rOATP1A1‐containing endocytic vesicles within cells, mediating recruitment of motor proteins required for microtubule‐based trafficking to the plasma membrane. rOATP1A4 also traffics to the plasma membrane, although it lacks a PDZ binding consensus sequence. The current study was designed to test the hypothesis that trafficking of rOATP1A4 to the plasma membrane requires its direct interaction with rOATP1A1 resulting in a complex that traffics through the cell in common subcellular vesicles in which the cytosolic tail of rOATP1A1 is bound to PDZK1. We found that 74% of rOATP1A4‐containing rat liver endocytic vesicles (n = 12,044) also contained rOATP1A1. Studies in transfected HEK293 cells showed surface localization of rOATP1A1 only when coexpressed with PDZK1 whereas rOATP1A4 required coexpression with rOATP1A1 and PDZK1. Studies in stably transfected HeLa cells that constitutively expressed PDZK1 showed that coexpression of rOATP1A4 with rOATP1A1 resulted in more rapid appearance of rOATP1A4 on the plasma membrane and faster maturation to its fully glycosylated form. Similar results were observed on immunofluorescence analysis of single cells. Immunoprecipitation of rat liver or transfected HeLa cell lysates with rOATP1A1 antibody specifically co‐immunoprecipitated rOATP1A4 as determined by western blotting. Conclusion: These studies indicate that optimal rOATP1A4 trafficking to the cell surface is dependent upon coexpression and interaction with rOATP1A1. As rOATP1A1 binds to the chaperone protein, PDZK1, rOATP1A4 functionally hitchhikes through the cell with this complex.
Serum exosomal microRNAs as novel biomarkers for multiple myeloma
Authors: Zhang Zhi‐yao , Li Yan‐chen , Geng Chuan‐ying , Zhou Hui‐xing , Gao Wen , Chen Wen‐ming 
Published: May 2019

AbstractAccumulating studies have focused on circulating microRNAs, which might be potential biomarkers for different malignancies. The aim of this study was to investigate the potential of serum exosomal microRNAs to be novel serum biomarkers for smouldering myeloma (SMM) or even multiple myeloma (MM). The levels of serum exosomal microRNAs and serum circulating microRNAs were measured in healthy individuals and patients with SMM (n = 20) or MM (n = 20). Serum exosomal microRNAs and serum circulating microRNAs were extracted from serum, and the expression levels of selected microRNAs were quantified by real‐time polymerase chain reaction (PCR). The levels of serum exosome‐derived miR‐20a‐5p, miR‐103a‐3p, and miR‐4505 were significantly different among patients with MM, patients with SMM, and healthy individuals, while there were differences in the levels of let‐7c‐5p, miR‐185‐5p, and miR‐4741 in patients with MM relative to those in SMM patients or healthy controls. Additionally, a significant correlation was rarely found between the levels of serum and exosomal microRNAs. This study shows that serum exosomal microRNAs can be used independently as novel serum biomarkers for MM.
Extramammary Paget's disease of the glans penis secondary to urethral recurrence of bladder carcinoma after radical cystectomy: A case report
Authors: Nishikawa Ryoma , Honda Masashi , Masago Toshihiko , Morizane Shuichi , Hikita Katsuya , Takenaka Atsushi 
Published: May 2019

IntroductionExtramammary Paget's disease of the vulva secondary to urothelial carcinoma is rare. It is important to determine whether extramammary Paget's disease is primary or secondary, because the appropriate treatment strategies differ. We report a case of penile extramammary Paget's disease secondary to urothelial carcinoma recurrence.Case presentationA 75‐year‐old man who was diagnosed with bladder carcinoma and received urethra‐sparing radical cystectomy 5 years ago presented with erythema and red spots in the glans penis. Immunostaining (cytokeratin 7 and cytokeratin 20) of skin biopsy specimens suggested a secondary extramammary Paget's disease that originated from the urothelial carcinoma. Under urethroscopy, urethral recurrence was also suspected. A total penectomy was performed, and a final diagnosis of urothelial carcinoma recurrence and secondary extramammary Paget's disease of the glans penis were established.ConclusionUsing immunostaining, the differential diagnosis between primary and secondary extramammary Paget's disease is more accurate. Secondary extramammary Paget's disease should be considered when a skin lesion is present on the penis of patients with urothelial carcinoma.
Bimodal recognition of affective states with the features inspired from human visual and auditory perception system
Authors: Selvaraj Arivazhagan , Russel Newlin Shebiah 
Published: May 2019

AbstractIn this article, attention‐based mechanism with the enhancement on biologically inspired network for emotion recognition is proposed. Existing bio‐inspired models use multiscale and multiorientation architecture to gain discriminative power and to extract meticulous visual features. Prevailing HMAX model represents S2 layers by randomly selected prototype patches from training samples that increase the computational complexity and degrade the discerning ability. As eyes and mouth regions are the most powerful and reliable cues in determining facial emotions, they serve as the prototype patches for S2 layer in HMAX model. Audio code 4 book is constructed from mel‐frequency cepstral coefficients, temporal and spectral features processed by principal component analysis. Audio and video data features are fused to train support vector machine classifier. The attained results on eNTERFACE, surrey audio‐visual expressed emotion and acted facial expressions in the wild database datasets ascertain the efficiency of the proposed architecture for emotion recognition.
Fuzzy relevance vector machine based classification of lung nodules in computed tomography images
Authors: Sathiya Thanikachalam , Sathiyabhama Balasubramaniam 
Published: May 2019

AbstractLung cancer is a critical disease with growing death rate, hence, the faster identification and treatment of lung cancer is essential. In medical image processing, the traditional methods like support vector machine, relevance vector machine for classifying cancer tissues are less sensitive to false data and required optimal improvement in classification accuracy. The proposed system of accurate lung cancer classification is obtained by a hybrid fuzzy relevance vector machine (FRVM) classifier with correlation negation ant colony optimization (CNACO) algorithm. This system provides enhanced accuracy and sensitivity by implementing two stages of feature extraction, image thresholding, and tumor segmentation, with a novel feature selection and tumor classification algorithm. The best features are selected by the proposed CNACO algorithm. The selected features are labeled and classified by FRVM classifier. The proposed classification scheme is validated on lung image database consortium and image database resource initiative public database and obtained accuracy of about 98.75%.
In situ diode laser fenestration: An ex‐vivo evaluation of irradiation effects on human aortic tissue
Authors: Piazza Roberta , Micheletti Filippo , Condino Sara , Magni Giada , Berchiolli Raffaella N. , De Simone Paolo , Ferrari Vincenzo , Ferrari Mauro , Pini Roberto , Rossi Francesca 
Published: May 2019

AbstractThe in situ laser fenestration is an interesting option for the endovascular treatment of short‐necked aneurysms with an intraoperative modification of a standard endograft. According to literature evidence, diode laser emitting in the near‐infrared wavelength (810 nm) can be successfully used to fenestrate the endograft fabric. This paper describes a three‐dimensional navigation system for the accurate targeting of the fenestration site, then reports results of an ex vivo study to assess whether the laser operative conditions, which ensure the fabric fenestration, are harmless for the biological tissue surrounding the endoprosthesis. Two hundred twenty‐five samples of human aorta, including healthy specimens and abdominal aortic aneurysm samples, were irradiated ex vivo using a 810 nm diode laser. Energy and pulse duration were varied. Irradiated tissues were fixed in formaldehyde, sectioned and subjected to histological examination. Only 7.5% of the irradiated samples exhibited a thermal damage, which was always confined to the contact point between the laser fiber tip and the aortic wall. These experiments suggest that the diode laser can be safely used for the proposed surgical application.
Optical flow sensor for continuous invasive measurement of blood flow velocity
Authors: Ruiz‐Vargas Albert , Morris Scott A. , Hartley Richard H. , Arkwright John W. 
Published: May 2019

AbstractContinuous monitoring of intrapulse measurement of blood flow in humans is currently not achievable with clinically available instruments. In this paper, we demonstrate a method of measuring the instantaneous variations in flow during pulsatile blood flow with an optical flow sensor comprising a fiber Bragg grating sensor and illumination from a 565 nm Light‐Emitting‐Diode. The LED illumination heats the blood and fluctuations in temperature, due to variations in flow, are detected by the fiber sensor. A set of experiments at different flow rates (20 to 900 mL/min) are performed in a simulated cardiac circulation setup with pulsatile flow. Data are compared with an in‐line time of flight ultrasound flow sensor. Our results show that the optical and ultrasonic signals correlate with Pearson coefficients ranging from −0.83 to −0.98, dependent on the pulsatile frequency. Average flow determined by ultrasound and the optical fiber sensor showed a parabolic relationship with R2 = 0.99. An abrupt step change in flow induced by occlusion and release of the circuit tubing demonstrated that the optical fiber and ultrasound sensor had similar response. The method described is capable of intrapulse blood flow measurement under pulsatile flow conditions, with potential applications in medicine where continuous blood flow sensing is desired.
IL‐1RA suppresses esophageal cancer cell growth by blocking IL‐1α
Authors: Chen Sui , Shen Zhimin , Liu Zhun , Gao Lei , Han Ziyang , Yu Shaobin , Kang Mingqiang 
Published: May 2019

AbstractBackgroundInterleukin‐1 promotes tumor angiogenesis through VEGF production. The interleukin‐1 receptor antagonist can suppress tumors by blocking this effect.MethodsImmunohistochemistry, WB, and gene sequencing were used to analyze the expression of IL‐1RA in esophageal cancer patients. WB was used to detect the expression of IL‐1RA and interleukin‐1α in esophageal cancer cells. Stable ESCC cell models overexpressing the IL‐1RA were constructed. Their cell functions were tested, and their effects on VEGF were examined.ResultsIL‐1RA is downregulated in primary EC tumors, and this downregulation of IL‐1RA is closely related to TNM staging and survival prognosis. The overexpression of IL‐1RA increased the proliferation of KYSE410 EC cells, which have a high level of IL‐1α expression. Overexpression of IL‐1RA in KYSE410 cells promotes a decrease in the expression of VEGF‐A. However, IL‐1RA expression did not cause any changes in EC9706 cells with low IL‐1α expression.ConclusionIL‐1RA acts as a tumor suppressor, and its deletion promotes tumor progression by increasing VEGF‐A expression in ESCC.