bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravascular Brachytherapy for the Management of Repeated Multimetal-Layered Drug-Eluting Coronary Stent Restenosis
Authors: Varghese Mithun J. , Bhatheja Samit , Baber Usman , Kezbor Safwan , Chincholi Aditi , Chamaria Surbhi , Buckstein Michael , Bakst Richard , Kini Annapoorna , Sharma Samin 
Published: October 2018

Background:
Because of the widespread acceptance of percutaneous coronary intervention with drug-eluting stents as an effective treatment strategy for in-stent restenosis, it is common to encounter multimetal layer stent restenosis in the recent years. This study aimed to evaluate the clinical outcomes of such patients treated with intravascular brachytherapy (IVBT) in comparison with other percutaneous options.

Methods and Results:

We enrolled patients who underwent percutaneous coronary intervention during the period between 2011 and 2015 for recurrent drug-eluting stents in-stent restenosis with at least 2 layers of stents at the lesion site. This analysis compared patients who underwent treatment with IVBT and those who did not (non-IVBT group). The primary end point measured was major adverse cardiac events defined as a composite of target lesion revascularization, myocardial infarction, and all-cause mortality at 12 months. Adjusted associations were measured using propensity score matching. A total of 328 percutaneous coronary intervention patients met the eligibility criteria, of which 197 patients received IVBT, and 131 patients underwent routine percutaneous intervention. The primary end point was significantly lower in patients undergoing IVBT (13.2% and 28.2%;
P
=0.01). A propensity score matching for risk factors of in-stent restenosis identified 182 patients. The advantages of IVBT with regard to 1-year major adverse cardiac events were confirmed in this matched cohort (13.2% and 30.8%; adjusted hazard ratio [95% CI]: 0.37 [0.18–0.73];
P
<0.01).

Conclusions:
In this analysis, IVBT led to significantly lower major adverse cardiac events in patients with multilayered drug-eluting stents restenosis when compared with other percutaneous options at 1-year follow-up.
Prediction of Ischemic and Bleeding Events Using the Dual Antiplatelet Therapy Score in an Unrestricted Percutaneous Coronary Intervention Population
Authors: Brener Sorin J. , Kirtane Ajay J. , Rinaldi Michael J. , Stuckey Thomas D. , Witzenbichler Bernhard , Weisz Giora , Neumann Franz-Josef , Metzger D. Christopher , Henry Timothy D. , Cox David A. , Duffy Peter L. , Mazzaferri Ernest L. , Gurbel Paul A. , Brodie Bruce R. , Mehran Roxana , McAndrew Thomas , Stone Gregg W. 
Published: October 2018

Background:
The dual antiplatelet therapy (DAPT) risk score was developed from the DAPT trial to inform the optimal duration of DAPT after percutaneous coronary intervention. We assessed the performance of the DAPT score in the ADAPT-DES (Assessment of Dual AntiPlatelet Therapy with drug-eluting stents) all-comers registry and tested the utility of additional predictors of adverse events.

Methods and Results:

Outcomes between 1 and 2 years were examined according to DAPT score ≥2 versus <2, adjusted for DAPT continuation as a time-dependent variable. To assess the incremental utility of variables not included in the DAPT score, baseline high platelet reactivity was added to the ischemia model, and high platelet reactivity, baseline hemoglobin, and warfarin use 1 year after percutaneous coronary intervention were added to the bleeding model. Among 8582 patients enrolled in ADAPT-DES, 5397 were event-free after 1 year. Between 1 and 2 years, ischemic (myocardial infarction or stent thrombosis) and bleeding events occurred in 75 (1.5%) and 124 (2.3%) patients, respectively. Patients with higher DAPT scores (≥2 versus <2) had higher rates of myocardial infarction or stent thrombosis (1.9% versus 1.1%;
P
=0.01) and similar rates of bleeding (2.2% versus 2.4%, respectively;
P
=0.79). For the prediction of myocardial infarction or stent thrombosis, bleeding and death, DAPT score ≥2 had sensitivities of 57%, 41%, and 56%, respectively; specificities of 58%, 57%, and 58%, respectively; positive predictive values of 1.9%, 2.2%, and 2.1%, respectively; and negative predictive values of 99%, 98%, and 99%, respectively. Addition of baseline high platelet reactivity to the DAPT score did not improve discrimination for ischemic events. Addition of high platelet reactivity and 2 other bleeding covariates to the DAPT score marginally improved discrimination.

Conclusions:
In ADAPT-DES, the DAPT score was predictive of ischemic events between 1 and 2 years after drug-eluting stents. Prediction of bleeding improved marginally after addition of variables not incorporated in the DAPT score.
Validation of a Rapid Attribution of the May/June 2016 Flood-Inducing Precipitation in France to Climate Change
Authors: Philip Sjoukje , Kew Sarah F. , Jan van Oldenborgh Geert , Aalbers Emma , Vautard Robert , Otto Friederike , Haustein Karsten , Habets Florence , Singh Roop 
Published: October 2018

AbstractThe extreme precipitation that resulted in historic flooding in central-northern France began 26 May 2016 and was linked to a large cutoff low. The floods caused some casualties and over a billion euros in damage. To objectively answer the question of whether anthropogenic climate change played a role, a near-real-time “rapid” attribution analysis was performed, using well-established event attribution methods, best available observational data, and as many climate simulations as possible within that time frame. This study confirms the results of the rapid attribution study. We estimate how anthropogenic climate change has affected the likelihood of exceedance of the observed amount of 3-day precipitation in April–June for the Seine and Loire basins. We find that the observed precipitation in the Seine basin was very rare, with a return period of hundreds of years. It was less rare on the Loire—roughly 1 in 20 years. We evaluated five climate model ensembles for 3-day basin-averaged precipitation extremes in April–June. The four ensembles that simulated the statistics agree well. Combining the results reduces the uncertainty and indicates that the probability of such rainfall has increased over the last century by about a factor of 2.2 (&gt;1.4) on the Seine and 1.9 (&gt;1.5) on the Loire due to anthropogenic emissions. These numbers are virtually the same as those in the near-real-time attribution study by van Oldenborgh et al. Together with the evaluation of the attribution of Storm Desmond by Otto et al., this shows that, for these types of events, near-real-time attribution studies are now possible.
The social inclusion of young people with serious mental illness: A narrative review of the literature and suggested future directions
Authors: Gardner Andrew , Filia Kate , Killackey Eóin , Cotton Sue 
Published: October 2018

Background: Social inclusion involves objective participatory (e.g. education/employment) and subjective (e.g. sense of belonging/acceptance) elements across multiple domains. It has been associated with enhanced physical and mental wellbeing yet is a novel construct in the empirical literature (i.e. measures have not been sufficiently developed). Aims: Young people with serious mental illness are reported to be socially excluded. It is unclear whether this is reflected in the social inclusion/exclusion literature. The aim of this narrative review is to determine whether such literature permits a comprehensive (i.e. multi-dimensional, objective and subjective) understanding of social inclusion among young people with serious mental illness. Methods: Searches to identify studies related to the social inclusion and/or exclusion of young people with serious mental illness were conducted on 16 February 2016, 24 August 2016, 16 February 2017, 24 August 2017 and 16 February 2018 in PsycINFO, MEDLINE, the Cochrane Library, SCOPUS, Open Grey, Web of Science, Google and Google Scholar. Results: There is a paucity of research in the explicit social inclusion literature involving young people either with or without serious mental illness as participants. Literatures exist in related independent areas of research (e.g. employment, social networks), but such studies employ heterogeneous methodologies. Conclusion: Multi-dimensional measures of social inclusion incorporating objective and subjective indicators must be developed for young people with and without serious mental illness. This will enable the generation of normative and clinical data. Existing evidence for the social exclusion of young people with serious mental illness comes from objective indicators in isolated domains (e.g. unemployment). Subjective indicators continue to be under-researched. The above-described measures must be employed to further understanding of the apparent discrepancies between young people with serious mental illness and those without serious mental illness. This will elucidate the relationships between objective and subjective elements of social inclusion and the relationships between these elements and the psychological distress that young people with serious mental illness often experience. This has implications for intervention.
Pharmacologic Management of Delirium in the ICU: A Review of the Literature
Authors: Korenoski Amanda , Li Angela , Kane-Gill Sandra L. , Seybert Amy L. , Smithburger Pamela L. 
Published: October 2018

Purpose: Conflicting data exists on the pharmacologic management of intensive care unit (ICU) delirium. This review appraises the current evidence of pharmacologic management of ICU delirium. Materials and Methods: A systematic literature search of MEDLINE and Embase was conducted to answer the population, intervention, comparison, and outcome (PICO) question of: “Does the use of a pharmacologic agent compared to standard of care or placebo improve ICU delirium in a critically ill patient population?” Results: After application of the PICO question and the inclusion and exclusion criteria, 13 articles were included. Of these articles, 7 were prospective randomized controlled trials, 1 was a prospective nonrandomized controlled trial, and 5 were retrospective investigations. The included articles differed in the agents evaluated, primary outcome, and method of identifying delirium. Conclusion: The variability of outcomes illustrates the need for a large-scale investigation to further evaluate the role of pharmacologic management of ICU delirium.
Diagnostic Assessment Reviews: is cost-effectiveness analysis helpful or necessary?
Authors: Mistry Hema , Mason James 
Published: October 2018

Objective Diagnostic Assessment Reviews are part of the work programme of the National Institute of Health and Care Excellence (NICE) in England to evaluate emergent medical technologies and so ensure timely and consistent adoption within the National Health Service (NHS). New diagnostics have the potential to improve health outcomes and impact positively on health service resource use. This study sought to assess the quality of economic evidence informing Diagnostic Assessment Reviews. Methods We reviewed 27 Diagnostic Assessment Reviews that had been published by NICE as of 30 May 2017 by summarizing and interpreting the evidence that was used to carry out cost-effectiveness analyses. Common issues and challenges of the assessment process were illustrated. Findings: DARs differed in the methods and assumptions used to construct economic models, and linkage of economic model and diagnostic findings. Even though some diagnostic technologies were estimated to be cost-effective, they were not always adopted for routine use in the NHS. The majority of Diagnostic Assessment Review economic models relied heavily on assumptions and expert opinion, with considerable uncertainty about the cost-effectiveness of diagnostic testing. Conclusions Diagnostic Assessment Reviews appraisals as commissioned by NICE typically feature varying evidence for diagnostic performance and limited evidence for resource implications and quality of life, often leading to recommendations for further research. Given the process opportunity cost, a two-stage topic selection process, with initial assessment specifying further research and proceeding to full assessment when adequate evidence is available may be more appropriate and help signal to diagnostics companies the type of research evidence required.
Clinical Outcomes Associated With Allogeneic Red Blood Cell Transfusions in Spinal Surgery: A Systematic Review
Authors: Blackburn Collin W. , Morrow Katherine L. , Tanenbaum Joseph E. , DeCaro Jessica E. , Gron Judith M. , Steinmetz Michael P. 
Published: October 2018

Study Design: Systematic review. Objectives: The objectives of this systematic review were to report the available clinical evidence on patient outcomes associated with perioperative allogeneic red blood cell (RBC) transfusions in adult patients undergoing spinal surgery and to determine whether there is any evidence to support an association between transfusion timing and clinical outcomes. Methods: A systematic review of the PubMed, EMBASE, and Cochrane Library databases was performed to identify all articles examining outcomes of adult spinal surgery patients who received perioperative allogeneic RBC transfusions. The level of evidence for each study was assessed using the “Oxford Levels of Evidence 2” classification system. Meta-analysis was not performed due to the heterogeneity of reports. Results: A total of 2759 unique citations were identified and 76 studies underwent full-text review. Thirty-four studies were selected for analysis. All the studies, except one, were retrospective. Eleven studies investigated intraoperative or postoperative transfusions. Only one article compared outcomes related to intraoperative versus postoperative transfusions. Conclusions: Perioperative transfusion is associated with increased rates of postoperative complications, especially infectious complications, and prolonged length of stay. Some evidence suggests that a dose-response relationship may exist between morbid events and the number of RBC units administered, but these findings are inconsistent. Because of the heterogeneity of reports and inconsistent findings, the incidence of specific complications remains unclear. Limited research activity has focused on intraoperative versus postoperative transfusions, or the effect of transfusion on functional outcomes of spine surgery patients. Further research is warranted to address these clinical issues.
A Comprehensive Return-to-Play Analysis of National Basketball Association Players With Operative Patellar Tendon Tears
Authors: Nguyen Michael V. , Nguyen John V. , Taormina David P. , Pham Hien , Alaia Michael J. 
Published: October 2018

Background: Patellar tendon tears impart potentially debilitating sequelae among professional basketball athletes. Hypothesis: Professional basketball athletes with patellar tendon tears have decreased return-to-play performance in seasons after injury compared with preinjury statistics. Study Design: Case series; Level of evidence, 4. Methods: Patellar tendon tears among National Basketball Association (NBA) athletes from the 1999-2000 to 2014-2015 seasons were identified. Player performance statistics for players who underwent operative patellar tendon repair were compared from 1 season before injury to 1 season after injury and 2 seasons before injury to 2 seasons after injury using the primary outcome of player efficiency rating (PER). Secondary performance outcomes were also analyzed. Results: A total of 13 patellar tendon tears (10 complete, 3 partial) were identified among 12 NBA athletes. Three players (25%) did not return to play in the NBA. No significant differences were found in PER in comparisons of 1 season before and after injury (16.6 ± 1.5 vs 14.3 ± 1.7; P = .20) or in comparisons of 2 seasons before and after injury (15.8 ± 0.8 vs 6.3 ± 2.3; P = .49). Diminished performance outcomes were noted for total minutes played (2598 ± 100 vs 1695 ± 78; P = .01), games played (74.8 ± 1.9 vs 60.5 ± 1.4; P = .04), and minutes per game (34.8 ± 1.5 vs 28.2 ± 1.8; P = .02) in comparisons of 1 season before and after injury. Total minutes played per season (2491 ± 190 vs 799 ± 280; P = .045) decreased in comparisons of 2 seasons before and after injury. Conclusion: Patellar tendon tears were not associated with diminished efficiency-adjusted performance, as measured by PER, games played, minutes per game played, points per 36 minutes, and rebounds per 36 minutes. However, decreases in total minutes played were observed following patellar tendon tear. Orthopaedic surgeons may be better prepared to counsel basketball athlete patients with patellar tendon tear given these findings.
The effects of cash transfers on adult labor market outcomes
Authors: Baird Sarah , McKenzie David , Özler Berk 
Published: October 2018

AbstractᅟThe basic economic model of labor supply has a very clear prediction of what we should expect when an adult receives an unexpected cash windfall: they should work less and earn less. This intuition underlies concerns that many types of cash transfers, ranging from government benefits to migrant remittances, will undermine work ethics and make recipients lazy. We discuss a range of additional channels to this simple labor-leisure trade-off that can make this intuition misleading in low- and middle-income countries, including missing markets, price effects from conditions attached to transfers, and dynamic and general equilibrium effects. We use this as a lens through which to examine the evidence on the adult labor market impacts of a wide range of cash transfer programs: government transfers, charitable giving and humanitarian transfers, remittances, cash assistance for job search, cash transfers for business start-up, and bundled interventions. Overall, cash transfers that are made without an explicit employment focus (such as conditional and unconditional cash transfers, and remittances) tend to result in little to no change in adult labor. The main exceptions are transfers to the elderly and to some refugees, who reduce work. In contrast, transfers made for job search assistance or business start-up tend to increase adult labor supply and earnings, with the likely main channels being the alleviation of liquidity and risk constraints.JEL ClassificationO15, J22, I38, H23
Relief effects correction on frequency-domain electromagnetic data
Authors: Valera Sifontes Rimary , Sato Hédison Kiuity 
Published: October 2018

During a frequency-domain electromagnetic (FDEM) land survey using transmitter-receiver distances of kilometer order, the receiver and transmitter may be at different altitudes. To increase the signal-to-noise ratio, the transmitting coil size must be increased to the order of a hundred meters and its geometry will be determined by the terrain roughness. Therefore, the equivalent magnetic dipole axis may be neither vertical nor normal to the mean plane representing the terrain surface. Considering the perpendicular loop-loop arrangement, these factors modify the expected secondary magnetic field in two ways: (1) A horizontal primary field arises at the receiving coil position as well as (2) the secondary fields induced by the abnormal currents in the subsurface caused by the tilting of the transmitter dipole axis. A correction procedure is proposed to remove these effects on field FDEM data and tested by using simulated FDEM data with two- or three-layered tilted models to represent the earth with a dipping surface and a nonvertically oriented transmitter magnetic dipole representing a large coil laid on rough terrain. The results demonstrate that the proposed correction procedure has a limited effectiveness, but it can be applied to the FDEM data collected on terrain surfaces having small dipping angles. It is observed that maximum values of the transmitter dipole or surficial plane tilt angle should be 2° to ensure error values in the apparent conductivity less than 10%. Even for the said value, in some combinations of geometric and physical parameters, the tilting and dipping angles can be increased to the order of 5°.
Internet Access and Breast Cancer Awareness Among Akure Residents
Authors: Anyanwu-Akeredolu Betty 
Published: October 2018

Purpose Of the leading types of cancer in women, breast cancer presents with the highest number of cases and is the leading cause of cancer death in less developed countries. Despite the promising positive impact of the Internet on breast cancer awareness, there is a paucity of information on the effect of Internet access on breast cancer knowledge in Nigeria. Therefore, the aim of this study was to determine the effect of Internet access on breast cancer knowledge and the perceived benefit of breast self-examination among adults residing in Akure Town, Ondo State, Nigeria. Methods A descriptive cross-sectional study design was used to determine the effect of access to the Internet on breast cancer knowledge and the perceived benefit of breast self-examination among Akure residents. The study was conducted in 295 men and women age 18 to 60 years residing in Akure who were selected using a systematic sampling technique. A telephone survey was used to collect data. Simple frequency distribution was used to describe the data, and bivariable logistic regression was used to test the association between variables. Results Almost all adults residing in Akure are aware of breast cancer and more than one half have a good knowledge of the disease. Although more than one half of the study population was found to have a good knowledge of breast cancer, most adults do not have knowledge of the risk factors of breast cancer. Nearly 97% of the 84% of participants who have ever conducted breast self-examination does so at least once in a month. Adults residing in Akure who have access to the Internet were more than two times more likely to have a good knowledge of breast cancer compared with their counterparts with no Internet access. Conclusion Knowledge of breast cancer is above average among Akure adults; however, more than one half of the adult populace in Akure still lacks adequate knowledge of the risk factors of breast cancer. Breast cancer awareness programs that are targeted at Akure residents should emphasize breast cancer risk factors and use the platform provided by the Internet. AUTHOR’S DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/site/ifc . No COIs from the author.