bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topical oxygen therapy stimulates healing in difficult, chronic wounds: a tertiary centre experience
Authors: Kaufman Hanna , Gurevich Maxim , Tamir Eran , Keren Elad , Alexander Lipkin , Hayes Paul 
Published: July 2018

Objective: Oxygen plays a central role in wound healing. Recent technological advances have miniaturised oxygen delivery systems, with novel topical oxygen therapy allowing patients to receive oxygen therapy 24 hours a day while remaining completely mobile. Here we aim to examine the efficacy and safety of continuous topical oxygen diffusion in a ‘real-world’ setting. Methods: Topical oxygen therapy (TOT) was evaluated in patients with chronic, non-healing wounds in a tertiary referral specialist clinic. Results: The mean wound duration before TOT was 15 months. Regardless of treatment duration, in this previously non-healing group complete wound closure was observed in 32% of the total patients treated with the TOT device. However, optimal wound healing occurred when the device was used for >25 days, with an 83% wound area reduction and 47% wound closure rate seen in venous leg ulcers (VLUs) and a 74% reduction and a 57% wound closure rate in arterial foot ulcers. Conclusion: Use of TOT in chronic wounds stimulates a healing state. In our study, almost half of the previously non-healing wounds closed.
Using AutoCAD software to measure venous leg ulcers: a reproducibility assessment study
Authors: Eberhardt Thaís D. , Lima Suzinara B.S. , Lopes Luis F.D. , Kessler Marciane , Fonseca Graziele G.P. , Soares Rhea S.A. 
Published: July 2018

Objective:To assess the reproducibility of using AutoCAD software to measure the area of venous leg ulcers (VLUs).Method:Data from patients with VLUs were collected between March and July 2015, using data collection forms and photographing the different ulcers. A researcher and five nurses collected the data. The wounds were measured using AutoCAD software. Data were analysed using intraclass correlation coefficient (ICC), concordance correlation coefficient (CCC) and Bland-Altman analysis.Results:A total of 21 patients with 36 VLUs were included in the study. A statistically significant difference (p<0.05) was observed between the areas of VLUs measured by the researcher and the evaluators. There was an excellent agreement when analysing the ICC [p=0.98; 95% CI (0.97–0.99); p <0.05] and the CCC [CCC=CI 0.97; 95% (0.95–0.98)]. There was no difference between the measurements of VLUs ≤10 cm2(p=0.49) and those with an area >10cm2(p=0.22).Conclusion:The use of AutoCAD software is appropriate for measuring VLUs and appears to be more accurate when used to measure VLUs with an area >10cm2.
Acetabular morphology in slipped capital femoral epiphysis: Comparison at treatment onset and skeletal maturity
Authors: Maranho D. A. , Davila-Parrilla A. , Miller P. E. , Kim Y.-J. , Novais E. N. , Millis M. B. 
Published: July 2018

Purpose To investigate changes in acetabular morphology during the follow-up of slipped capital femoral epiphysis (SCFE) and search for factors associated with acetabular dysplasia at skeletal maturity. Methods We evaluated 108 patients with unilateral SCFE (mean age at slip, 12.3 years sd 1.7) to skeletal maturity, with a minimum follow-up of two years (median 4.5 years; interquartile range 3.2 to 6.2). Acetabular parameters obtained from initial and most recent radiographs included the lateral centre-edge angle (LCEA), Tönnis angle (TA) and acetabular depth-width ratio (ADR). Acetabular dysplasia was considered for LCEA < 20° or TA > 10°. Femoral parameters consisted of the most recent head diameter, neck-shaft angle, neck length, articulotrochanteric distance and alpha angle. Results At SCFE onset, the affected hip showed a slightly lower LCEA (26.4° sd 6.1° versus 27.3° sd 5.7°; p = 0.01) and ADR (330 sd 30 versus 340 sd 30; p < 0.001) compared with the uninvolved hip. At final follow-up, the affected hip showed lower LCEA (24.5° sd 7.6° versus 28.8°sd 6.6°; p < 0.001) and ADR (330 sd 40 versus 350 sd 40; p < 0.001), and TA was larger (5.5° sd 5.4° versus 2.3° sd 4.2°; p < 0.001) compared with the uninvolved hip. Acetabular dysplasia was observed in 27 (25%) of 108 hips with SCFE. Femoral head overgrowth, age at slip and SCFE severity were independent factors associated with acetabular dysplasia (p < 0.05). Conclusion Acetabular coverage and depth are not increased in SCFE, and the acetabular coverage tends to decrease up to skeletal maturity. A potential disturbance in the acetabular growth and remodelling exists mainly for young children with severe SCFE, and a potential for acetabular insufficiency may be observed at the diagnosis and follow-up of SCFE. Level of Evidence Prognostic Level IV
Characterization of Tissue Plasminogen Activator Expression and Trafficking in the Adult Murine Brain
Authors: Stevenson Tamara K. , Lawrence Daniel A. 
Published: July 2018

AbstractTissue plasminogen activator (tPA) is an immediate-early gene important for regulating physiological processes like synaptic plasticity and neurovascular coupling. It has also been implicated in several pathological processes including blood-brain barrier (BBB) permeability, seizure progression, and stroke. These varied reports suggest that tPA is a pleiotropic mediator whose actions are highly compartmentalized in space and time. The specific localization of tPA, therefore, can provide useful information about its function. Accordingly, the goal of this study was to provide a detailed characterization of tPA’s regional, cellular, and subcellular localization in the brain. To achieve this, two new transgenic mouse lines were utilized: (1) a PlatβGAL reporter mouse, which houses the β-galactosidase gene in the tPA locus and (2) a tPABAC-Cerulean mouse, which has a cerulean-fluorescent protein fused in-frame to the tPA C-terminus. Using these two transgenic reporters, we show that while tPA is expressed throughout most regions of the adult murine brain, it appears to be preferentially targeted to fiber tracts in the limbic system. In the hippocampus, confocal microscopy revealed tPA-Cerulean (tPA-Cer) puncta localized to giant mossy fiber boutons (MFBs) and astrocytes in stratum lucidum. With amplification of the tPA-Cer signal, somatically localized tPA was also observed in the stratum oriens (SO)/alveus layer of both CA1 and CA3 subfields. Coimmunostaining of tPA-Cer and interneuronal markers indicates that these tPA-positive cell bodies belong to a subclass of somatostatin (SST)/oriens-lacunosum moleculare (O-LM) interneurons. Together, these data imply that tPA’s localization is differentially regulated, suggesting that its neuromodulatory effects may be compartmentalized and specialized to cell type.
A resolução de problemas como prática interdisciplinar na educação: uma proposta epistemetodológica
Authors: Fávero Altair Alberto , Tonieto Carina , Possel Bianca 
Published: July 2018

O objetivo deste texto é apresentar a resolução de problemas como uma possibilidade de prática interdisciplinar a partir de uma concepção epistemetodológica, buscando pensar alternativas metodológicas que tornem possível a experimentação da interdisciplinaridade no contexto escolar/acadêmico. A pergunta provocadora e orientadora aqui apresentada é: a concepção epistemológica-metodológica da resolução de problemas é uma alternativa promissora para a construção de práticas interdisciplinares na educação? Este estudo consiste numa pesquisa bibliográfica e exploratória. Metodologicamente, representa uma análise teórica ancorada no método analíticohermenêutico, orientada epistemologicamente por uma perspectiva racionalista, tomada em seu posicionamento crítico-analítico e enfoque da complexidade. Na primeira parte do texto, apresenta-se a concepção epistemológica de Popper (2013; 2008; 2004; 1975), ancorada na proposta do método de conjecturas e refutações que se baseia na criação e resolução de problemas, a partir do qual é possível a construção e reconstrução do conhecimento; e, na segunda parte, apresenta-se a proposta epistemetodológica da colocação e resolução de problemas como possibilidade de prática interdisciplinar nos processos de ensino e aprendizagem, amparados em Pozo (2008) e Sommermman (2015). A conclusão é que a proposta epistemetodológica da resolução de problemas é uma alternativa promissora para a construção de práticas interdisciplinares na educação, devido ao potencial criativo.No entanto, não representa apenas a aquisição de ferramentas e procedimentos capazes de gerar soluções quandoaplicados em si mesmos e por si mesmos, já que enquanto método precisa estar associado aos conteúdos deaprendizagem.
Politización y transformaciones sociales en los pueblos de campaña del Estado de Buenos Aires, 1852-1861
Authors: Zubizarreta Ignacio 
Published: July 2018

Resumen: El artículo analiza el proceso de legitimación de las elites políticas porteñas en el intrincado ámbito rural gracias a un proceso también impulsado por varios sectores de vecinos de campaña. Buscamos con él contribuir a comprender mejor las transformaciones en la cultura y en las prácticas sociales post Caseros, en la yuxtaposición de dos tendencias historiográficas que se han ocupado de estudiar la politización del mundo rural y la construcción del estado (State Building). Nos focalizaremos en las nuevas prácticas políticas y sociales iniciadas al calor de una ampliada libertad de prensa y del surgimiento de clubes recreativos y políticos.Palabras clave: campaña-Estado de Buenos Aires-política-sociabilidad-mediados del s. XIX----------------- Politicization and social transformations in the rural villages of the State of Buenos Aires, 1852-1861 Abstract: The purpose of this article is to analyze the process of legitimization of the political elites of Buenos Aires in the intricate rural sphere as a result of a process likewise promoted by several neighboring rural sectors. Its aim is to contribute to a better understanding of the post-Caseros cultural transformations and social practices and of the transformations in the juxtaposition of two historiographical tendencies that have dealt with the politicization of the rural world and with State building. Its main focus will be the new political and social practices that began in the heat of a greater press freedom and of the rise of recreational and political clubs. Keywords: countryside-State of Buenos Aires-politics-sociability- mid-19th Century
Validación de un modelo de gestión empresarial para pequeñas y medianas empresas (PYMES) basado en dinámica de sistemas
Authors: Samaniego Guevara Hernan Washington 
Published: July 2018

El propósito de este trabajo investigativo es demostrar la validación de un modelo de gestión empresarial diseñado acorde a la metodología de la dinámica de sistemas, el cual es aplicado exclusiva y específicamente a las pequeñas y medianas empresas (PYMES). La validación del modelo posibilita tener la seguridad de que el mismo está en concordancia a las necesidades organizacionales de este tipo de empresas. Para la validación del modelo se utiliza la técnica de recopilación de datos, utilizando para esto información seleccionada y obtenida durante un lapso de tiempo específico, analizando que dicha información sea relevante, confiable y correcta; considerando que, al estudiar un determinado sistema, conviene analizar su comportamiento a partir de datos representativos de lo que se espera que sea su funcionamiento habitual y no con datos correspondientes a situaciones extremas. La conjunción de la metodología de la dinámica de sistemas y la técnica de recopilación de datos para validar el modelo generado, posibilita efectuar simulaciones las cuáles permiten a las PYMES ratificar o rectificar las políticas de gestión administrativas que aplican al interior de sus empresas.
Synthesis of Gold Nanobipyramids by Seed-mediated Method and Santibacterial Activities
Authors: Ngo Thanh Vo Ke , Huynh Phat Trong , Nguyen Anh Thi Kim , Nguyen Giang Dang , Lam Vinh Quang 
Published: July 2018

Metallic nanoparticles as antibacterial agents have been studied for several years. The most used antibacterial nanoparticles are silver nanoparticles. The mechanisms and antibacterial properties of silver nanoparticles are well known, but the effects of gold nanoparticles, especially gold Nano bipyramids, are not considered. In this research, we synthesized gold nanobipyramids (NBPs) by seed mediated method using surfactant cetyltrimethylammonium bromide (CTAB). After preparing, gold nanobipyramids is removed CTAB and modified the surface using polyethylene glycol, polyvinyl alcohol and chitosan as the stabilizers. Besides, antibacterial effects of gold nanobipyramids on both Escherichia coli (Gram negative) and Staphylococcus aureus (Gram positive) are investigated in this paper. The results show that gold nanobipyramids have good antibacterial activities even at low concentration. The optimal concentration of stabilizers and gold nanobipyramids in antibacterial activities are also studied in this paper.
CHANGES IN URINE MICROFLORA IN CHILDREN WITH COMMUNITY-ACQUIRED URINARY TRACT INFECTION ADMITTED TO HOSPITAL BETWEEN 1990 AND 2015: A RETROSPECTIVE FULL-DESIGN STUDY OF CASE SERIES
Authors: Zhdanova Olga A. , Nastausheva Tatyana L. , Grebennikova Irina V. , Batishcheva Galina A. , Balalaeva Irina Yu. 
Published: July 2018

Background. It is necessary to study the microbial spectrum of urine in order to determine the features of the urinary tract infection (UTI) course and to make the right choice of a therapeutic approach. Objective. Our aim was to study the structure of urine microflora in children with community-acquired UTI and its change in the period from 1990 to 2015.Methods. We conducted a continuous analysis of case histories of children admitted to hospital with UTI (pyelonephritis, cystitis, non-site specific urinary tract infection) in 1990, 2000, and 2015. We studied the results of triple (in succession) urine cultures. Shedding in a concentration of ≥ 103 cfu/ml for primary pathogens, ≥ 103 cfu/ml in boys and ≥ 104 cfu/ml in girls for secondary pathogens, ≥ 105 cfu/ml for doubtful pathogens considered to be a diagnostically significant one.Results. Members of the family Enterobacteriaceae were the main causative agents of the UTI in 1990 (found in 90.4% of 502 samples), 2000 (in 79.7% of 632 samples), and 2015 (in 67.6% of 801 samples, df = 2, p < 0.001). Escherichia coli remained the most common microorganism, the isolation rate of which decreased from 79.9% in 1990 to 39.5% in 2015 (p < 0.001). In the period from 2000 to 2015, there was a decrease in the frequency of urine detection of Enterobacter spp. (from 5.9 to 2.5%; p < 0.001) and Citrobacter spp. (from 5.2 to 1%; p < 0.001) and, on the contrary, an increase in the isolation rate of Proteus spp. (from 7.8 to 11.7%; p = 0.005), Klebsiella spp. (from 2.8 to 12.9%; p < 0.001) and Enterococcus spp. (from 1.8 to 19.1%; p < 0.001); the latter two — due to more frequent shedding in boys (by 10.5 and 19.9%, respectively).Conclusion. The Enterobacteriaceae members, mainly E. coli and Enterococcus spp., remained the predominant UTI pathogens in children in 1990, 2000, and 2015. The isolation rate of E. coli has declined significantly in recent years, whereas that of Klebsiella spp. and Enterococcus spp. has increased.
ALLERGIC RHINITIS IN PRE-SCHOOL CHILDREN LIVING IN URBAN SETTINGS OF THE ALTAI REGION: A POPULATION-BASED CROSS-SECTIONAL STUDY
Authors: Shakhova Natalia V. , Kamaltynova Elena M. , Lobanov Yuriy Ph. , Ardatova Tatyana S. 
Published: July 2018

Background.It is necessary to study the prevalence and risk factors of allergic rhinitis (AR) among pre-school children in order to develop a disease prevention strategy.Objective.Our aim was to study the prevalence, clinical and allergological features, and risk factors for AR in pre-school children living in urban settings of the Altai Region.Methods.At the screening stage, the study enrolled children aged 3–6 years attending pre-school educational institutions in 5 cities of the Altai Region. AR symptoms were determined using the ISAAC questionnaire. The AR was diagnosed if ≥ 2 symptoms (rhinorrhea, nasal breathing difficulty, itching in the nasal cavity, repetitive sneezing) lasted ≥ 1 h with a positive prick test and/or a blood level of specific IgE > 0.35 kU/L to at least one allergen (total 11).Results.The prevalence of AR in urban children aged 3–6 years (n = 3,205) was 10.6%; 48% of them were previously diagnosed with AR. 85% of children had a persistent course of the disease; 69% had mild AR. Most often, there was established sensitization to house dust mites (61.6%), birch pollen (40.9%), and cat fur (19.4%). The risk factors for AR were family history of allergies [odds ratio (OR) 4.2; 95% confidence interval (CI) 3.5–5.9], masculine (OR 2.8, 95% CI 1.9–4.0), smoking parents (OR 1.8, 95% CI 1.2–2.9), nonadherence to a regimen/dosage of vitamin D3 intake in infancy (OR 1.8, 95% CI 1.2–2.8), presence of asthma-like symptoms (OR 10.2, 95% CI 7.2–14.5), and manifestations of atopic dermatitis (OR 6.0, 95% CI 4.2–8.5).Conclusion.AR occurs in every tenth pre-school child (mainly of mild severity and persistent course), every second disease among them was diagnosed for the first time. Sensitization occurs to typical for childhood allergens. The risk factors for AR are family history of allergies, masculine, passive smoking, ignoring the recommendations of taking vitamin D3 in infancy, the presence of atopic dermatitis, and asthma-like symptoms.
A CASE OF THE EARLY DEVELOPMENT OF ATOPIC DERMATITIS IN A NURSING INFANT
Authors: Turti Tatiana V. , Bokuchava Ekaterinа G. , Illarionov Alexey S. , Selivanova Anastasiya G. 
Published: July 2018

Background.The early (in the first months of life) formation of atopic status and the development of allergies are not uncommon pathological conditions in a pediatrician's practice, requiring sufficiently studied and theoretically grounded measures for the organization of primary/secondary prevention.Case Report.The parents visited a doctor with complaints of widespread skin rashes and troubled night sleep in a child from the age of two months. A burdened history of allergies of the child was traced through the female lineage (food allergy in the mother, maternal sister and grandmother). The perinatal period is complicated by acute respiratory infection in the third trimester and by maternal nutritional preferences (consumption of goat's and whole cow's milk). The delayed (on the 5th day of life) breastfeeding initiation, feeding with cow's milk-based formula, living next to an industrial enterprise, maternal choices of products with a high sensitizing potential not only during pregnancy but also during breastfeeding probably caused the early formation of atopic status — dry skin, widespread papular rash, microvesicles on the cheeks, hips, shins, scratching traces, serous-bloody crusts objectively defined at admission. The SCORAD scores corresponded to severe atopic dermatitis. The ImmunoCAP technology revealed high antibody titres to a number of products, including cow's milk and chicken egg proteins. Based on the findings, a therapeutic diet aimed at secondary prevention of allergic diseases, including respiratory allergies, was developed for the child.Conclusion.A case of the early (from 2 months) formation of atopic status with the development of atopic dermatitis caused by polyvalent food sensitization is described. A therapeutic diet containing products with a low sensitizing potential was prescribed for the child. The suggested therapy including the diet should prevent the progression of an allergic disease.
Quando eu sou o Outro: problemas de ethos e identidade no filme Pequeno Grande Homem
Authors: De Oliveira Carlos Böes 
Published: July 2018

RESUMO: Este artigo pretende estudar a relação da construção do ethos e da identidade no personagem principal do filme Pequeno Grande Homem (Little Big Man, 1970) de Arthur Penn, além de salientar as representações do Outro (os nativos norte-americanos) na narrativa fílmica. Através de um encontro interdisciplinar entre componentes da Análise do discurso (AD), da linha francesa de Maingueneau, e os estudos culturais, propomos uma visão mais ampla sobre a questão do eu e do Outro no gênero de faroeste. Os referencias teóricos estão focados em Tzvetan Todorov e Stuart Hall, para analisarmos a questão do Outro, a cultura e a identidade. Para enveredarmos na temática do ethos, buscamos teorias do discurso baseadas nos estudos de Dominique Maingueneau, que, por sinal, pertencem à linha de pesquisa da AD de linha francesa. Pretendemos, através deste estudo, problematizar a questão do Outro, entendendo que o personagem principal do filme desconstrói um ethos pré-discursivo, estabelecido na cultura norte-americana, em que a tradição via o nativo como selvagem e bestial.
PALAVRAS-CHAVE: Pequeno Grande Homem; outro; ethos; identidade; faroeste.

ABSTRACT: This paper intends to analyze the relation of ethos and identity construction in the protagonist of the film Little Big Man (Arthur Penn, 1970), besides stressing out the representations of the Other (the North American natives) in the filmic narrative. Through an interdisciplinary approach between components of the Discourse Analysis from the French studies of Maingueneau, and cultural studies, we propose a substantial vision about the matter of the other and I in the western genre. The theoretical references are focused on Tzvetan Todorov and Stuart Hall, to analyze the matter of the other, culture and identity. To analyze the discursive ethos, we relied on discourse theories based on the studies of Dominique Maingueneau, that, by the way, belong to the French Discourse Analysis. Through this study, we intend to problematize the issue of the other, understanding that the protagonist of the film deconstructs a pre-discursive ethos, established on the North American culture, where tradition saw the native as a savage.
KEYWORDS: Little Big Man; other; ethos; identity; western.