bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats
Authors: Neckář Jan , Hye Khan Md. Abdul , Gross Garrett J. , Cyprová Michaela , Hrdlička Jaroslav , Kvasilová Alena , Falck John R. , Campbell William B. , Sedláková Lenka , Škutová Šárka , Olejníčková Veronika , Gregorovičová Martina , Sedmera David , Kolář František , Imig John D. 
Published: April 2019

Abstract
Epoxyeicosatrienoic acids (EETs) and their synthetic analogs have cardiovascular protective effects. Here, we investigated the action of a novel EET analog EET-B on the progression of post-myocardial infarction (MI) heart failure in spontaneously hypertensive rats (SHR). Adult male SHR were divided into vehicle- and EET-B (10 mg/kg/day; p.o., 9 weeks)-treated groups. After 2 weeks of treatment, rats were subjected to 30-min left coronary artery occlusion or sham operation. Systolic blood pressure (SBP) and echocardiography (ECHO) measurements were performed at the beginning of study, 4 days before, and 7 weeks after MI. At the end of the study, tissue samples were collected for histological and biochemical analyses. We demonstrated that EET-B treatment did not affect blood pressure and cardiac parameters in SHR prior to MI. Fractional shortening (FS) was decreased to 18.4 ± 1.0% in vehicle-treated MI rats compared with corresponding sham (30.6 ± 1.0%) 7 weeks following MI induction. In infarcted SHR hearts, EET-B treatment improved FS (23.7 ± 0.7%), markedly increased heme oxygenase-1 (HO-1) immunopositivity in cardiomyocytes and reduced cardiac inflammation and fibrosis (by 13 and 19%, respectively). In conclusion, these findings suggest that EET analog EET-B has beneficial therapeutic actions to reduce cardiac remodeling in SHR subjected to MI.
The CMB angular power spectrum via component separation: a study on Planck data
Authors: Umiltà C. , Cardoso J. F. , Benabed K. , Le Jeune M. 
Published: April 2019

Aims. We investigate the extent to which foreground-cleaned cosmic microwave background (CMB) maps can be used to estimate cosmological parameters at small scales.
Methods. We use the SMICA method, a blind separation technique that works directly at the spectral level. In this work we focus on the small scales of the CMB angular power spectrum, which are chiefly affected by noise and extragalactic foregrounds, such as point sources. We adapt SMICA to use only cross-spectra between data maps, thus avoiding the noise bias. In this study, performed using both simulations and Planck 2015 data, we fit for extragalactic point sources by modelling them as shot noise of two independent populations.
Results. In simulations, we correctly recover the point-source emission law, and obtain a CMB angular power spectrum that has an average foreground residual of one fifth of the CMB power at ℓ ≥ 2200. With Planck data, the recovered point-source emission law corresponds to external estimates, with some offsets at the highest and lowest frequencies, possibly due to frequency decoherence of point sources. The CMB angular power spectrum residuals are consistent with what we find in simulations. The cosmological parameters obtained from the simulations and the data show offsets up to 1σ on average from their expected values. Biases on cosmological parameters in simulations represent the expected level of bias in Planck data.
Conclusions. The results on cosmological parameters depend on the detail of the foreground residual contamination in the spectrum, and therefore a tailored modelling of the likelihood foreground model is required.
Freundliche Distanzwesen
Authors: Höke Heike 
Published: April 2019

SummaryTiergestützte Therapien sprechen die uralte Verbindung des Menschen zu Tier und Natur an und eröffnen damit einen instinktiven und sofort abrufbaren Zugang mit großem therapeutischen Potenzial. Die Arbeit mit Tieren kann bei Menschen mit Autismus Kommunikationsstörungen, Ängste und Verhaltensauffälligkeiten deutlich verbessern. Lamas und Alpakas eignen sich durch ihr zurückhaltendes Wesen hervorragend für die Therapie autistischer, psychisch oder geistig beeinträchtigter Menschen.
Management der schweren idiopathischen Darmträgheit
Authors: Sailer Marco 
Published: April 2019

ZusammenfassungBei der schweren idiopathischen Obstipation (sog. „slow transit constipation“) handelt es sich um eine seltene Erkrankung, die fast ausschließlich bei Frauen in der 3. und 4. Lebensdekade angetroffen wird. Pathophysiologie und Ätiologie dieser Erkrankung sind nur z. T. bekannt, wobei es sich offensichtlich um ein multifaktorielles Geschehen handelt. Differenzialdiagnostisch müssen mechanische, medikamentöse, degenerative, metabolische, endokrinologische, neurologische und psychiatrische Ursachen der Obstipation ausgeschlossen werden. Hierzu ist eine umfangreiche interdisziplinäre Abklärung erforderlich. Zudem müssen gastrointestinale Funktionsanalysen gefordert werden, wobei der Bestimmung der Kolontransitzeit eine Schlüsselrolle zufällt. Wichtig ist weiterhin der Nachweis bzw. Ausschluss einer pangastrointestinalen Passagestörung, einer Beckenbodendysfunktion oder eines Colon irritabile. Die Initialtherapie der Slow Transit Constipation ist grundsätzlich konservativ. Nur bei gut dokumentiertem Therapieversagen sollte eine operative Behandlung erwogen werden. Als Standardverfahren hat sich die subtotale Kolektomie mit ileorektaler Anastomose durchgesetzt. Wesentliche Komplikationen der operativen Therapie sind Dünndarmileus, Inkontinenz und Persistenz oder Rezidiv von Obstipation und Abdominalschmerzen. Bei korrekter Patientenselektion kann mit einer Erfolgsquote von über 80% gerechnet werden.
Mirabegron, A Selective β3-Adrenoceptor Agonist Causes an Improvement in Erectile Dysfunction in Diabetic Rats
Authors: Yilmaz-Oral Didem , Kaya-Sezginer Ecem , Askin Dilan , Hamurtekin Yesim , Gur Serap 
Published: April 2019

Abstract
Aim To investigate the possible beneficial effect of mirabegron [a selective β3-adrenoceptor (AR) agonist] treatment on erectile dysfunction (ED) in streptozotocin-induced diabetic rats.
Methods Sprague-Dawley rats (n=20) were divided into two groups: control group and streptozotocin-induced diabetic group. In vivo erectile responses were evaluated after intracavernosal injection of mirabegron (0.4 mg/kg) in rats. The relaxation responses to electrical field stimulation (EFS, 10 Hz), sodium nitroprusside (SNP, 10 nM) and sildenafil (1 μM) of corpus cavernosum (CC) strips were examined after the incubation with mirabegron (10 μM). β3-ARs expression and localization were determined by Western blot and immunohistochemical analyses in CC tissue.
Results In vivo erectile responses of diabetic rats [intracavernasal pressure (ICP) / mean arterial pressure, 0.17±0.01] were decreased, which were restored after administration of mirabegron (0.75±0.01, P<0.001). The basal ICP (7.1±0.6 mmHg) in diabetic rats was markedly increased after mirabegron (36.1 ±5.4 mmHg, P<0.01). Mirabegron caused markedly relaxation in diabetic rat CC after phenylephrine precontraction. The relaxation responses to EFS and sildenafil were reduced in diabetic CC, which were increased in the presence of mirabegron. Mirabegron enhanced SNP-induced relaxation response in both groups. The expression and immunoreactivity of β3-ARs localized to CC smooth muscle were observed in control and diabetic rats.
Conclusions This is the first study to show that intracavernosal administration of mirabegron improved erectile function and neurogenic relaxation of CC in diabetic rats. These results may be supported by further studies using combinations of mirabegron and phosphodiesterase type 5 (PDE5) inhibitors for the treatment of diabetic ED, especially in patients who do not respond to PDE5 inhibitor therapy.
Gar nicht vegetarisch …
Authors: Bierbach Elvira 
Published: April 2019

SummaryHeparin, Hyaluron und Co.: Obwohl sie auch synthetisch produziert werden könnten, werden viele Wirk- und Hilfsstoffe aus tierischen Materialien gewonnen. Der Grund sind die niedrigeren Kosten. Die Tiere, die als Quelle für die benötigten Substanzen dienen, werden in der Regel unter den Bedingungen der Massentierhaltung gezüchtet, gehalten und konsumiert. Verbrauchern, aber auch Verordnenden, ist oftmals nicht bewusst, dass ein Medikament oder Nahrungsergänzungsmittel tierische Substanzen (aus der Massentierhaltung) enthält.
Platelet Counts in Uncomplicated Pregnancies at Term
Authors: Riera Gregorio , Galindo Megan , Turrentine Mark 
Published: April 2019

Abstract
Objective This study aimed to evaluate platelet counts at delivery in uncomplicated pregnancies between 37 and 41 weeks of gestation.
Study Design Platelet counts in women 16 to 45 years of age from August 1, 2011, through May 15, 2018, with a singleton pregnancy that delivered from 370/7 to 416/7 weeks of gestation. Women with pregnancy-related complications, preexisting disorders, or on medications that could affect platelet counts were excluded.
Results A total of 18,526 women had uncomplicated pregnancies with mean platelet count from 370/7 to 416/7 weeks of gestation of 220 × 109/L. The lower limit 95th percentile (2.5% quantile) was 120 × 109/L. Platelet counts decreased weekly from 37 to 41 weeks of gestation, becoming significant at 39 weeks of gestation and beyond, compared with 37 weeks (p < 0.01). Mean platelet counts: 225 × 109/L at 37 weeks, 223 × 109/L at 38 weeks, 219 × 109/L at 39 weeks, 218 × 109/L at 40 weeks, and 216 × 109/L at 41 weeks of gestation. Platelet counts of less than 150 × 109/L occurred in 9.7%.
Conclusion Platelet counts in uncomplicated pregnancies decrease weekly from 37 to 41 weeks of gestation. This will be important to consider when serial platelet values are monitored for other indications.
How Can Pelvic MRI with Diffusion-Weighted Imaging Help My Pregnant Patient?
Authors: Horowitz Jeanne M. , Hotalen Irene M. , Miller Emily S. , Barber Emma L. , Shahabi Shohreh , Miller Frank H. 
Published: April 2019

AbstractThe purpose of this review is to explain how diffusion-weighted imaging (DWI) is used during magnetic resonance imaging (MRI) exams in pregnant patients for specific maternal indications, including evaluation of acute pelvic pain, adnexal masses, cancer diagnosis and staging, and morbidly adherent placenta. While ultrasound is often the appropriate initial imaging for evaluating a pregnant patient, MRI can be helpful when a pelvic ultrasound is indeterminate. MRI has advantages in that it does not use ionizing radiation and has shown no known deleterious effects to the fetus. The use of gadolinium-based contrast is controversial during pregnancy. DWI is a functional sequence performed during an MRI exam, which is valuable in the absence of gadolinium contrast, and can increase the visibility of inflammation, abscesses, and tumors. Case examples will be presented to demonstrate the utility and added value of DWI over conventional anatomic T1- and T2-weighted imaging in diagnosis of maternal disease in the pregnant patient's pelvis.
Conditional sentences in the Old East Frisian Brokmonna Bref
Authors: Brennan Roland K. 
Published: April 2019

AbstractThis paper offers a descriptive account of conditional sentences in theBrokmonna Bref(Brookmen’s Charter), an Old East Frisian regional law text of the thirteenth century. The text shows peculiarities of compositional design, particularly the systematised employment of verb-initial conditional sentences, attested to a lesser degree in other East Frisian texts, and which a comparative perspective reveals as sporadic outside Old Frisian. The descriptive approach provides a suitable opportunity to revisit, from the syntactic side, questions of phraseological inheritance in the language of Old Frisian law. In presenting data, this research takes initial steps towards further study of Old Frisian syntax and its relationship to West Germanic structures.
Un nuovo testimone del volgarizzamento veneto dell’Esopus attribuito a Gualtiero Anglico
Authors: Beretta Andrea 
Published: April 2019

Astratto
L’articolo intende dare conto del ritrovamento di un nuovo testimone del volgarizzamento veneto
dell’Esopus attribuito a Gualterus Anglicus, del quale era precedentemente noto un solo
codice (London, British Library, 38023), edito da Vittore Branca. Il manoscritto che qui si presenta (segnato Venezia, Biblioteca
Nazionale Marciana, It. Z 74 (4826)) reca anche il testo integrale della fonte latina e si configura dunque come un esemplare
notevolissimo nell’ambito della fortuna della favolistica esopica in Italia. L’analisi fornisce una descrizione il più accurata
possibile del codice e del suo corredo illustrativo, e illumina i rapporti dei due testimoni latino e veneto in esso compresi con
il resto delle rispettive tradizioni testuali. Particolarmente interessante risulta inoltre l’esame dell’aspetto linguistico del
testo veneto: la maggiore antichità del codice Marciano (trecentesco) rispetto al (quattrocentesco) Londinese consente infatti di
delineare con maggiore chiarezza le diverse componenti di base della lingua del volgarizzamento.
The Revolt of the Mice
Authors: Idema Wilt L. 
Published: April 2019

Abstract
The tale of the war of the mice against the cat has a history of several thousands of years. First known from ancient
Egypt, it was wide-spread in Classical antiquity, would remain popular in the Near East until modern times, and also was widely known in
Europe in medieval and early modern times in paintings, prints, songs, and mock-epics. In China the most popular tale on the antagonism of
mice and cats was the tale of their underworld court case. Starting from the first half of the nineteenth century, some versions of that
tale also include an account of the war between the two species. Only one stand-alone treatment of the theme is known from an edition of the
1920s. In Japan the theme of the war of the mice against the cats also makes its first appearance in print in the first half of the
nineteenth century. No direct foreign influence can be discerned in the emergence of this theme in either country.
Statistical properties of hybrid estimators proposed for GEDI—NASA’s global ecosystem dynamics investigation
Authors: Patterson Paul L , Healey Sean P , Ståhl Göran , Saarela Svetlana , Holm Sören , Andersen Hans-Erik , Dubayah Ralph O , Duncanson Laura , Hancock Steven , Armston John , Kellner James R , Cohen Warren B , Yang Zhiqiang 
Published: April 2019

Abstract
NASA’s Global Ecosystem Dynamics Investigation (GEDI) mission will collect waveform lidar data at a dense sample of ∼25 m footprints along ground tracks paralleling the orbit of the International Space Station (ISS). GEDI’s primary science deliverable will be a 1 km grid of estimated mean aboveground biomass density (Mg ha−1), covering the latitudes overflown by ISS (51.6 °S to 51.6 °N). One option for using the sample of waveforms contained within an individual grid cell to produce an estimate for that cell is hybrid inference, which explicitly incorporates both sampling design and model parameter covariance into estimates of variance around the population mean. We explored statistical properties of hybrid estimators applied in the context of GEDI, using simulations calibrated with lidar and field data from six diverse sites across the United States. We found hybrid estimators of mean biomass to be unbiased and the corresponding estimators of variance appeared to be asymptotically unbiased, with under-estimation of variance by approximately 20% when data from only two clusters (footprint tracks) were available. In our study areas, sampling error contributed more to overall estimates of variance than variability due to the model, and it was the design-based component of the variance that was the source of the variance estimator bias at small sample sizes. These results highlight the importance of maximizing GEDI’s sample size in making precise biomass estimates. Given a set of assumptions discussed here, hybrid inference provides a viable framework for estimating biomass at the scale of a 1 km grid cell while formally accounting for both variability due to the model and sampling error.
Investigation of the Development of Hypersensitivity and Hyperalgesia After Repeated Application of Platelet-Rich Plasma in Rats: An Experimental Study
Authors: Ince Bilsev , Yıldırım Mehmet Emin Cem , Kilinc Ibrahim , Oltulu Pembe , Dadaci Mehmet 
Published: April 2019

Abstract

Background
Hyperalgesia, defined as hypersensitivity to pain, refers to sensitization of nociceptors to normal levels of pain.

Objectives
We aimed to determine whether hyperalgesia occurs due to the development of sensitization following repeated applications of platelet-rich plasma (PRP), and to ascertain the mechanism responsible for inducing hyperalgesia.

Methods
This study, performed between 2016 and 2017, involved 32 rats. A 2 cm × 2 cm area was shaved on the back of 10 experimental and 10 sham control animals. In the experimental animals this area was divided into 4 equal squares of 1 cm × 1 cm, and these squares were numbered 1 (no treatment; only the needle was inserted), 2 (0.2 mL, saline), 3 (0.2 mL, nonactivated PRP), and 4 (0.2 mL, activated PRP). The response of the animals to painful stimuli in these areas was investigated with Von Frey filaments, immediately before application and 4 weeks after the last application. Skin biopsies were taken, and growth factors were evaluated pathologically and biochemically.

Results
Hyperalgesia developed in all 4 areas of each experimental rat but not in the sham group. However, areas 3 and 4 had smaller Von Frey g values than areas 1 and 2. When growth hormones were assessed histopathologically and biochemically, nerve growth factor (NGF) levels were found to be higher in areas 3 and 4 than in areas 1 and 2 and the sham group.

Conclusions
Both nonactivated and activated PRP resulted in greater hypersensitivity than saline and sham treatment. Development of hyperalgesia may be associated with an increase in NGF as well as increased inflammatory mediators.
Total artificial heart implantation after right ventricular intimal spindle cell sarcoma
Authors: Smail Hassiba , Monteagudo-Vela Maria , Stock Ulrich , Simon Andre 
Published: April 2019

Abstract
This paper describes the case of a patient with a high-grade spindle sarcoma in the right ventricle. The patient underwent total cardiectomy followed by the implantation of a total artificial heart. The patient had an uneventful postoperative course and remained tumour-free for 12 months; after that time period she underwent a heart transplant.
Alveolar ridge alterations in the maxillary anterior region after tooth extraction through orthodontic forced eruption for implant site development: a clinical CBCT study
Authors: Papadopoulou Alexandra K , Papageorgiou Spyridon N , Hatzopoulos Stavros A , Tsirlis Anastasios , Athanasiou Athanasios E 
Published: April 2019

SummaryObjectiveTo investigate the effects of orthodontic forced eruption (OFE) with the straight-wire appliance in the dimensions of the alveolar process when used for extracting compromised maxillary anterior teeth and implant site development.Material and MethodsCone-beam computed tomography (CBCT) scans of 7 patients needing extraction of 17 maxillary anterior teeth were obtained before and immediately after OFE. Alveolar plate height and thickness measurements were performed on the buccal and palatal socket walls in CBCT sagittal cross sections. Statistical analysis included sample size calculation, paired t-test, and Wilcoxon test to evaluate alveolar plate dimensional changes and linear regression analysis to assess whether bone changes and the feasibility of implant insertion were associated to tooth type and root length, baseline alveolar plate thickness, and age.ResultsOFE caused statistically significant reduction of the buccal alveolar plate height (1.95 ± 1.83 mm) and significant increase of the palatal alveolar plate height (1.31 ± 2.41 mm) in the central tooth socket areas. Buccal reduction was associated positively to the baseline root length and negatively to the thickness of the corresponding plate in the apical level. A non-significant increase was noted in both buccal (0.23 ± 0.93 mm) and palatal (0.63 ± 1.59 mm) proximal bone. Inadequate buccal bone support hindered immediate implant placement in six sockets; however, all inserted implants showed adequate and gradually increasing stability from insertion to final restoration.ConclusionsOFE resulted in favourable increase in the heights of the palatal and proximal alveolar bone and significant reduction in the buccal plate height, which inhibited implant placement in 35% of the treated sockets.
Changes in Fathers’ and Mothers’ Time with Children: Spain, 2002–2010
Authors: Cano Tomás 
Published: April 2019

AbstractParental time spent with children is a critical determinant for a child’s cognitive, educational, and socio-emotional development. Using two waves of the Spanish Time Use Surveys, this study aims to investigate how mothers and fathers reorganized the time invested in physical and developmental childcare between 2002 and 2010. Results show that, during the period analyzed (marked by the start of the Great Recession in 2007), there had been: (i) a significant increase in the time fathers and mothers invested in childcare (i.e. an intensification of parenting); (ii) a gender convergence in physical care time, primarily driven by couples with very young children; and (iii) the gap in developmental childcare time invested between parents with and without a university degree remained unchanged. The decomposition of the results shows that the increase in father-child time is explained by a combination of changes in behavioural and compositional factors (i.e. increase in unemployment and level of education), whereas for changes in mother-child time, behavioural factors predominantly applied. These findings reinforce ideas of the rapid intensification of parenting, and a slow movement towards gender convergence in parental time spent with children.