bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis and subsequent molecular docking of selected phytochemicals with SLC6A3 and SLC6A4 as potential therapeutic agents for Obsessive-Compulsive Disorder (OCD)
Authors: Warshaneyan Swarn S. , Srivastava Prachi 
Published: September 2019

ABSTRACTObsessive-Compulsive Disorder (OCD) is one of the most problematic disorders of the brain. It lies in the category of moodomics disorders and can be identified by the presence of recurring intrusive thoughts (“compulsions”) and urges to do certain things repeatedly (“obsessions”), with a definite lack of control on these tendencies and their intensity affecting the patient’s daily life. It is known to be associated with not only anxiety disorder but also depression, with its cause being unknown, although possessing genetic components. Several separate methods are being attempted to develop an effective therapy for OCD but this field of research requires more focus. In the present course of research, there is an attempt to signify the molecular analysis approach by testing potential drugs computationally with previously identified targets, i. e. dopamine active transporter (DAT or SLC6A3) and sodium-dependent serotonin transporter (SERT or 5-HTT or SLC6A4) – two proteins which have been observed playing a major role in the manifestation of OCD symptoms. Their 3D structure prediction has already been done in the previous course of study. In continuation to the previous study, there is an attempt to screen out the potentially useful phytochemicals against this moodomics disorder. Several potentially useful phytochemicals are known to associate with SLC6A3 and SLC6A4, which have been identified through the text mining of various publications. First of all, these phytochemicals are analysed through the use of Molinspiration software followed by selection of the ones suitable as drug candidates using Lipinski’s Rule of five and finally, best docking configurations identified using AutoDock 4 in order to obtain potential therapeutics for OCD patients. Nuciferine, Epicatechin (EC), Retinal, Aphidicolin and Salvinorin A are showing good docking scores but among all these phytochemicals, Nuciferin, an extract of Indian Lotus plant, appears to be the one most suitable compound on the basis of binding energy calculations. Hence, we can say this could be a good revealing therapeutic agent for this disorder.
Impact of consumer information acquisition confidence, social outcome confidence on information search and sharing
Authors: Zubair Ahsan , Shabbir Rizwan , Abro Muhammad Azeem , Mahmood Mahmood A. Husain 
Published: September 2019

Purpose
This study aims to highlight the impact of information acquisition confidence and social outcome confidence on information search and information share intention. Moreover, the role of subjective knowledge is analyzed as a mediating variable among these relations.

Design/methodology/approach
This study conducted a survey which generated 233 valid responses. The data were analyzed using component factor analysis and structural equation modeling. Whereas, to examine the mediating effect, Hayes and Preacher (2008) model for statistical mediation analysis was used.

Findings
The results mainly supported the model by confirming that subjective knowledge, information acquisition confidence and social outcome confidence are positively related to information search intention. No association between information acquisition confidence and information sharing intention was found. The study's findings also suggested a positive association of social outcome confidence, subjective knowledge and information acquisition confidence with information share intention. Moreover, the results revealed that there is a significant and positive mediating effect of subjective knowledge between information acquisition confidence and information search intention. Subjective knowledge also acts as a mediator in the relationship between social outcome confidence and information sharing intention.

Practical implications
This study will be helpful for marketers and policymakers for designing marketing strategies which can enhance the flow of information. Moreover, this study will ensure the importance of information to marketers.

Originality/value
This paper fulfills an identified need to study the impact of consumer information acquisition confidence, social outcome confidence on information search and sharing with mediating role of subjective knowledge.
The scale of school organizational culture in Indonesia
Authors: Burhanuddin Burhanuddin 
Published: September 2019

Purpose
The purpose of this paper is to develop a measurement model in order to investigate sorts of organizational cultures (OCs) existing in school organizations.

Design/methodology/approach
This study involved 300 teachers of Primary Schools in the Malang City, East Java Indonesia. It used a quantitative approach with structural equation modelling to develop a measurement model of school OC. To enable the measure of this variable to work, OC scale was constructed and validated employing a confirmatory factor analysis.

Findings
Results suggest items of the scale are conceptualized as unidimensional measure. The scale, thus, could be used to examine and properly identified types of OCs within a school setting.

Research limitations/implications
This study developed e-scale to measure OC within a school context. The measure was tested in referring to the data derived from a limited sample of primary school teachers in Malang City, Indonesia.

Practical implications
This study recommends that school principals are expected to create an OC to ensure the improvement of individual capacities is carried out effectively.

Originality/value
The investigation focused on a school OC as a complex project. Since not many research studies developed the scales to measure this specific cultural construct, the findings add to the theory in this area.
A hierarchical model to enhance financial and strategic performance of an oil and gas company in Malaysia
Authors: Krishnan Deven , Islam Rafikul , Sarif Suhaimi Mhd. 
Published: September 2019

Purpose
The purpose of this study intends to develop a hierarchical model through prioritisation of the core competencies with respect to competitive advantage, financial and strategic performance for an oil and gas company in Malaysia.

Design/methodology/approach
Mixed method approach used in the present research. Initially, interviews were conducted to solicit information about the company’s core competencies, competitive advantage, and financial and strategic performance. The interview findings used for questionnaire development to rank core competencies with respect to competitive advantage, financial and strategic performance. The survey results were analysed using the analytic hierarchy process (AHP), a mathematical model and is synthesised using Super Decisions Software.

Findings
The study developed a hierarchical model and can be set as a benchmark for prioritising core competencies, with respect to competitive advantage, financial and strategic performance for oil and gas companies.

Practical implications
The prioritisation results will help the company considered in the present research and also the similar companies to optimise their resources and energy to focus on the desired and the most influential core competencies.

Social implications
As the oil industry develops competitive advantage, its success will cascade down to stimulate the nation’s growth, support industry and services expansion and eventually develop the nation.

Originality/value
This study is a first of its kind in using AHP to rank core competencies with respect to competitive advantage, financial and strategic performance for an oil and gas company. The results can be used by oil and gas companies to enhance their overall performance.
“Home-buying behaviour model of Generation Y in Turkey”
Authors: Kayapinar Kaya Sema , Ozdemir Yasal , Dal Murat 
Published: September 2019

Purpose
The young population in Turkey is gradually increasing. Generation Y, which comprises the people born between 1980 and 1999 (Broadbridge et al., 2007) and free-spirited and tech-savvy, forms a large part of the population of the world, especially Turkey, and is of great importance to the housing sector for their home-buying preferences. In this study, housing preferences of students in Turkey’s two socio-economically different universities were comparatively analysed through quantitative methods.

Design/methodology/approach
A survey was simultaneously distributed among students of two universities. The survey consists of six main factors: “reliability”, “economic opportunities”, “transportation opportunities”, “quality of life and social opportunities”, “quality standards”, and “technological opportunities”, with 25 statements. The questionnaire was developed through a comprehensive literature review and the opinions of university stakeholders.

Findings
Results showed that the structure of the family and socio-economic differences affect home-buying preferences. The Mann–Whitney U test indicated that there was a meaningful difference of opinion between students of two universities. Munzur University students paid attention to economic opportunities when buying a home. Additionally, there was a meaningful relationship among the age groups in factors of “having a parking place” (p = 0.026) and “having a playground” (p = 0.026). As the age increases, students desire a playground around their future home.

Research limitations/implications
The most important limitation of this study is the non-parametric data. Non-parametric data structure and the tests performed accordingly are less preferred than parametric data structure. For that reason, to what extent the results accurately represent Generation Y needs to be assessed through future study. Also, a certain number of sampling could be reached as purposive sampling was used.

Originality/value
This study contributes to the literature in terms of comparatively analysing buying preferences of Generation Y through statistical methods and showing the relationship between these preferences and socio-economic features statistically. Due to the insufficient quantitative research on the literature, this quantitative study was carried future home-buying preferences of Generation Y university students, who will also be actively involved in the housing market. The purpose of this study investigates marketing factors that affect housing preferences of students in Turkey.
Supply chain sales forecasting based on lightGBM and LSTM combination model
Authors: Weng Tingyu , Liu Wenyang , Xiao Jun 
Published: September 2019

Purpose
The purpose of this paper is to design a model that can accurately forecast the supply chain sales.

Design/methodology/approach
This paper proposed a new model based on lightGBM and LSTM to forecast the supply chain sales. In order to verify the accuracy and efficiency of this model, three representative supply chain sales data sets are selected for experiments.

Findings
The experimental results show that the combined model can forecast supply chain sales with high accuracy, efficiency and interpretability.

Practical implications
With the rapid development of big data and AI, using big data analysis and algorithm technology to accurately forecast the long-term sales of goods will provide the database for the supply chain and key technical support for enterprises to establish supply chain solutions. This paper provides an effective method for supply chain sales forecasting, which can help enterprises to scientifically and reasonably forecast long-term commodity sales.

Originality/value
The proposed model not only inherits the ability of LSTM model to automatically mine high-level temporal features, but also has the advantages of lightGBM model, such as high efficiency, strong interpretability, which is suitable for industrial production environment.
Risk perceptions and adaptation strategies of smallholder farmers to climate change and variability in North Shoa Zone, Ethiopia
Authors: Tesfahun Azmeraw Ayehu , Chawla Arevendor S. 
Published: September 2019

PurposeThe purpose of this paper is to explore smallholder farmers’ risk perception associated with climate change, the adaptation strategies used and determinants of their adaptation decision behaviour in Eferatena-Gidem district, Ethiopia.Design/methodology/approachThe study used household survey methods of data collection. The data were collected using a structured questionnaire survey by interviewing 261 randomly selected smallholder farmers and analysed using both descriptive and inferential data analysis techniques including Participation Index, Adaptation Strategy Index and Binary Logistic Regression Model.FindingsResults of the survey revealed that the vast majority of the respondents perceived the long-term changes in temperature and rainfall pattern. Although they are not transformational in nature, the majority (77 per cent) of the respondents who had perceived changes in climate took adaptive measures. Results of the econometric model analysis revealed that farmers’ perceptions of climate change, extension contact frequency, farmers’ attitude towards adaptation measures, tailor-made training and membership of farmers in peasant associations were found to be significant predictors that positively influenced farmers’ decision behaviour, whereas off-farm employment and the age of the household head were found to be negative and significant determinants.Practical implicationsThis study, in general, provides an insight into the risk perception, adaptive response and determinants of farmers’ decision behaviour in implementing response strategies and suggests that policies and strategies intended at building the adaptive capacity of the farming community in the study area need to take into account the aforementioned significant factors and framers risk perception, as they highly determine their decision behaviour and help in designing effective and context-specific adaptation strategy.Originality/valueThe findings of this study could be informative for policy makers and development practitioners in designing locally specific effective adaptation menu that shapes adaptation to current and future climate risks.
Green sourcing practices in Korea
Authors: Min Hokey , Choi Seok-Beom 
Published: September 2019

Purpose
Based on the empirical findings from a survey of Korean firms with greater environmental risks, this paper aims to identify variables that either promote or inhibit the successful implementation of green sourcing strategy and to evaluate the effects of green sourcing on the firm’s supplier selection, waste management, packaging and regulatory compliance.

Design/methodology/approach
To help multinational firms configure an environmentally conscious (green) sourcing strategy, this paper conducted a mail-questionnaire survey and then analyzed the survey results obtained from more than 300 valid responses by using a series of multinomial logistics regression, ordinal regression and discriminant analyses. In addition, the authors performed a cluster analysis, chi-square tests of independence and cross tabulation to analyze the data.

Findings
The authors found that the main driver for the firm’s green sourcing practices is its customer needs and preferences for the environment-friendly product and services instead of peer pressure or government mandates (including environmental regulation). Surprisingly, the authors also found that the firm with a greater purchasing power did not necessarily factor the supplier’s advances in environmental programs into its supplier selection, although the firm’s amount of purchase volume can give it a bargaining strength to pressure its supplier to adopt the environmental programs.

Originality/value
A rapid industrialization of Asia-Pacific countries for the past several decades brought unprecedented economic prosperity in those countries. However, it also eroded ecosystem quality gradually through air, water and ground contamination and pollution caused by industrial activities. Such concerns have prompted many firms in the Asia-Pacific region to reassess their up-stream supply chain strategy such as sourcing strategy. This paper is one of the first to examine how Asia-Pacific firms develop such strategy and identify the most common green sourcing practices that can be guidance for other firms embracing environmental programs.
Effects of citrus latifolia extract on dyslipidemia and tissues redox status in rats fed a high-cholesterol diet
Authors: Mir Hakima , Krouf Djamil , Taleb-Dida Nawal , Berzou Sadia , Guenzet Akila , Khelladi HadjMostefa 
Published: September 2019

Purpose
This study aims to investigate the possible effect of Citrus latifolia (CL) extract on biomarkers of oxidative stress, including lipid peroxidation products in rats fed a high cholesterol diet

Design/methodology/approach
Hypercholesterolemia was induced by feeding normocholesterolemic rats 1 per cent cholesterol-enriched diet for 15 days. An experimental group (n = 20) was divided into two groups (n = 10) and fed the same diet with or without CL lyophilized aqueous extract (1 per cent) for four weeks. At day 28, ten rats from each group were killed.

Findings
Treatment with CL lyophilized aqueous extract compared with the untreated group had decreased plasma total cholesterol (TC) (−36 per cent), triacylglycerols (−48 per cent), isoprostanes values (−74 per cent) and reduced thiobarbituric acid reactive substances in erythrocytes (−21 per cent). However, the supplementation of CL peels in the hypercholesterolemic diet enhanced superoxide dismutase (+69 per cent), glutathione reductase (+30 per cent) and catalase activities (+34 per cent).

Originality/value
In hypercholesterolemic rats, administering CL extract ameliorates dyslipidemia and attenuates lipid peroxidation in tissues. These results suggest that CL could be beneficial in the primary treatment of hypercholesterolemia and oxidative damage caused by a high-cholesterol diet.
Determining a suitable carbon source for the production of intracellular pigments from Monascus purpureus HBSD 08
Authors: Huawei Zeng , Chengtao Wang , Jie Qiao , Bingjing Zhang , Bing Zhao , Chuangyun Dai 
Published: September 2019

Purpose
The Monascus pigment has been widely applied in the food processing industry as a functional additive. Lovastatin and polysaccharides are two important bio-active materials found in Monascus. Citrinin is considered as mycotoxin. Thus, it is important to produce high yields of intracellular Monascus pigments with high yields of lovastatin and polysaccharides, while maintaining low citrinin yields under liquid fermentation.

Design/methodology/approach
The intracellular yields of pigments, lovastatin, polysaccharides and citrinin; biomass; and reducing the sugar content of Monascus purpureus HBSD 08 were determined every day during a 10-day culturing period using lactose, maltose, sucrose, glucose, glycerine and xylose as the sole carbon sources. Additionally, the pigment composition was analysed by a thin layer chromatography (TLC) and the in vitro antitumor activities of the pigments were determined.

Findings
The maximal yield of pigments (55.44 U/mL after six days of culture) and lovastatin content (1,475.30 µg/L after five days of culture) were obtained in the presence of glucose and maltose as the sole carbon sources, respectively. The suitable carbon sources for high intracellular polysaccharides yields were sucrose, maltose and xylose. Glucose should not be chosen as the sole carbon source because of its high food safety risk. In vitro antitumor activities of pigments in the presence of different carbon sources were in the order of xylose > glucose = maltose > glycerine > sucrose = lactose. The pigment compositions in the presence of different carbon sources were the same from the TLC analysis. Thus, maltose displayed high intracellular yields of pigments, lovastatin and polysaccharides; high food safety against citrinin, and high in vitro antitumor activity during the ten days culturing period.

Originality/value
This study shows us the benefits of using maltose as a substrate in the production of intracellular Monascus pigments while ensuring economic and food safety.
Protest and prayer: the Jewish and Catholic presence at Selma
Authors: Callahan Cory , Hubbard Janie 
Published: September 2019

Purpose
The recent motion picture Selma infused fresh interest – and controversy – into the political and emotional peak of America’s modern Civil Rights Movement. Ava DuVernay, the film’s director, faced criticism for her exclusion of the Jewish presence from the movie’s portrayal of the March 21, 1965 Voting Rights March. The recent attention presents a teachable moment and new energy for thinking deeply about this pivotal event in America’s past. The paper aims to discuss these issues.

Design/methodology/approach
The authors provide valuable historical domain knowledge surrounding the 1965 Voting Rights March, present the requisite plans and curriculum resources for implementing wise-practice instructional strategies, and explore the rationale underpinning the inquiry-based activities.

Findings
The authors share innovative approaches, at the secondary and elementary levels, integrating historical domain knowledge with renewed interest in the 1965 Voting Rights March to create powerful teaching-and-learning experiences. The approaches are innovative because they contain dynamic curriculum materials and reflect wise-practice use of historical photographs within the College, Career, and Civic Life (C3) Framework for Social Studies State Standards.

Practical implications
The approaches shared here are centered around questioning, a key to student learning. The lessons feature the development of questions, both from teachers and students, as classes work collaboratively to interpret a potentially powerful historical photograph and use historical events to practice thinking deeply about important topics.

Originality/value
Social studies classrooms are ideal educational spaces to develop and practice the analytical skills and dispositions students need to meet the challenge of critiquing visual information that concerns complex public issues, such as the role of religion in society.
Tourism employment paradoxes, 1946-2095: a perspective article
Authors: Baum Tom , Solnet David , Robinson Richard , Mooney Shelagh K. 
Published: September 2019

Purpose
This is an invited 75article for Tourism Review addressing tourism employment, past and future.

Design/methodology/approach
Conceptual analysis of tourism employment with a focus on paradox.

Findings
Inherent paradox which underpins tourism employment.

Originality/value
A wholly original take on tourism employment.