bluuebunny/crossref_metadata_2025_split huggingface dataset:
A sustainable and green HPLC-PDA technique for the simultaneous estimation of Post-COVID-19 syndrome co-administered drugs with greenness and whiteness assessment
Authors: Medhat Passant M. , Fouad Manal Mohamed , Monir Hany H. , Ghoniem Nermine S. 
Published: October 2024

AbstractCOVID-19 has been a growing global concern in the past four years. Several syndromes associated with this multi-organ viral infection have been observed since the outbreak. According to estimates, 10–15% of people with SARS-CoV- infection may have post-COVID-19 syndrome. Even months after infection, common residual signs and symptoms include myalgia, exhaustion, shortness of breath, rapid heartbeat, stroke, and memory and cognitive impairment which can negatively affect survivors’ quality of life and may consequently lead to their death. Therefore, it is necessary to think about potential therapy options for dealing with both short and long-term impacts. Paracetamol (a common analgesic and antipyretic) and Dexketoprofen Trometamol (a non-steroidal anti-inflammatory drug) are used together to relieve post-COVID symptoms like myalgia (muscle pain) and headache. Additionally, to prevent thrombotic events, Rivaroxaban is recommended for 35 days following discharge. Thus an eco-friendly HPLC-DAD technique was developed for simultaneous quantification of Paracetamol, Dexketoprofen Trometamol, and Rivaroxaban which are co-administered for treatment of post-COVID-19 syndrome. The suggested method was found to be linear in the concentration ranges of 3.00–45.00 µg/mL, 0.5–50.00 µg/mL, and 0.15–20.00 µg/mL, and a limit of detection down to 0.531 µg/mL, 0.095 µg/mL and 0.047 µg/mL for Paracetamol, Dexketoprofen Trometamol and Rivaroxaban, respectively. This method was effectively used to quantify the studied drugs in their bulk powder and spiked human plasma with high percentage recoveries (96.55–99.46%). The suggested approach was validated per International Conference on Harmonization (ICH) requirements and found to be within the acceptable ranges. The method was developed using Green Analytical Chemistry (GAC) principles, with the solvents used and run time having a significant effect on the method’s greenness. “Non-toxic” ethanol served as the organic modifier in the mobile phase, moreover, the total run time was 12 min making it suitable for the routine analysis of the mentioned drugs in plasma samples. To get a full image of the method’s greenness profile; two most recent greenness assessment tools, the Green Analytical Procedure Index (GAPI), and the Analytical GREEnness metric (AGREE), were employed, with White Analytical Chemistry (WAC) principles proving its environmental safety.
The Leaders in Informatics, Quality, and Systems (LInQS) Fellowship
Authors: Hallman Heather , Pell Jonathan , Ho P. Michael , Montague Brian , Schilling Lisa , Sieja Amber , Ream Karen , Anstett Tyler 
Published: October 2024

Abstract
Background Leaders in Informatics, Quality, and Systems (LInQS) is a non-ACGME (Accreditation Council for Graduate Medical Education)-accredited 2-year training program developed to enhance training in the fields of health care delivery, quality improvement (QI), clinical informatics, and leadership.
Methods This single-institution 2-year longitudinal training program grounded in QI and informed by leadership and clinical informatics includes didactics, coaching, and mentorship, all centered around individualized QI projects. The program has been available to sub-specialty fellows, advanced practice providers, and physicians.
Results From 2019 to 2023, 32 fellows have been accepted into the program with 13 graduates and 16 currently enrolled. Fellows have been predominately female, physicians, and from multiple specialties but predominantly hospital medicine. Fellows' evaluations of the fellowship are highly positive, rating the didactics and mentorship aspects of the curriculum most favorably. Most fellows' projects utilized informatics solutions including clinical decision support tools to increase quality of care, improve patient outcomes, and reduce costs of care resulting in manuscript publications, national presentations, and a national specialty society award. Since matriculation, 50% of fellows received certification as Epic Physician Builders and 34% received leadership positions in clinical informatics, quality, and education.
Conclusion Our experience supports the need to provide health care providers more expansive training in the areas of QI, clinical informatics, and leadership for improving health care delivery. Additional in-depth knowledge and experience in these fields may produce and benefit leaders in these fields.
The role of L1-dialect in L2 production
Authors: Li Ying 
Published: October 2024

Abstract
This study compared the productions of American English (AE) vowels /i/, /u/, /ɛ/, /ɔ/, /ɪ/, /æ/, /ʊ/, /ʌ/, and /ɑ/ between speakers of two Chinese dialects, the Leshan dialect (LSd) and the Xining dialect (XNd). The participants were native speakers of XNd (n = 120) and LSd (n = 120) with advanced English proficiency. Their vowel productions were compared with those of 22 native AE speakers. The results showed that (1) XNd and LSd participants significantly differed in F1 and/or F2 from AE participants when producing /ɪ/, /æ/, /ʌ/, and /ʊ/ and /ɪ/, /ɑ/, /ɔ/, and /ʌ/, respectively; (2) compared with AE participants, XNd participants had significantly longer durations of /ɪ/, /ʊ/, /ʌ/, /ɛ/, and /æ/, and LSd participants had significantly longer durations of /ɪ/, /ʌ/, and /ɛ/. Overall, the vowels that differed in production from that of native speakers were absent in both the L1 dialects and L1 of participants.
Exploring the potential of CdSe nanostructured thin films for energy conversion and environmental remediation
Authors: Hassan J J , Kadhim Marwah J , Almusawe A J , Mahdi M A , Saadon H L 
Published: October 2024

Abstract
The rapid thermal evaporation method was employed to prepare cadmium selenide (CdSe) nanostructured thin films with varying thicknesses on glass and FTO substrates. The films were characterized for their structural, optical, and electrochemical properties. Scanning electron microscope (SEM) analysis revealed inhomogeneous surfaces with particle sizes ranging from 18 to 46 nm. The photocatalytic performance of the CdSe films was evaluated by the degradation of methylene blue (MB) dye under visible light, with varying pH values, achieving a degradation efficiency of 100% at pH 10 after 180 min. Photocurrent density measurements demonstrated the films’ ability to sense visible light. We performed a cyclic voltammetry (CV) measurement and analyzed the CV curves of the CdSe nanostructured thin film electrodes. It clearly shows that the CV curves had a rectangular shape, which suggests that EDLC behavior was present and non-faradaic capacitance was the main type. The photoconversion efficiency measured is 1.4858 at a bias voltage of 0.66 V under illuminated conditions. Nonlinear optical properties were conducted for CdSe nanostructured thin films.
Effect of Na atom adsorption on the electronic structure of F-doped modified MoTe2 systems in the presence of an electric field: first principles
Authors: Dai Ying , Liu Guili , Mohammadzadeh Ardashir , Zhang Guoying 
Published: October 2024

Abstract
The effect of electronic structure and charge transfer on the adsorption of alkali metal sodium atoms by halogen-fluorine atom doped molybdenum ditelluride (MoTe2) has been investigated using a first-principles approach. It was found that the molybdenum ditelluride system underwent a direct bandgap semiconductor-to-metal transition after doping with halogen fluorine atoms. Upon adsorption of alkali metal Na atoms, the conduction band of the F-MoTe2 system shifts from metal to direct bandgap semiconductor. This semiconductor-to-metal-to-semiconductor bandgap modulation method can be well applied to photovoltaics. In addition, we discuss three potential adsorption sites: the hollow site (H), the bridge site (B) and the top site (T). The results showed that all three adsorption sites could be stabilized for adsorption. Subsequently, we selected the most stable B site and applied an electric field ranging from −0.5 eV Å−1 to 0.5 eV Å−1 to the system. At an electric field strength of −0.5 eV Å−1, the system transforms from a direct bandgap semiconductor to a metal. In terms of density of states, F-s, F-p, Te-s, Te-p, and Mo-d pass the Fermi energy level, increasing carrier concentration. It is hoped that these studies will play an important role in improving the photoelectric conversion efficiency.
Single photon avalanche diode dark count rate modelling considering non-local avalanche probability
Authors: Nasiri M. , Eyvazi K. , Karami M.A. 
Published: October 2024

Abstract
This article deals with the modeling and analysis of the
dark count rate (DCR) of single photon avalanche diodes (SPAD) in
two models of local and non-local electric field. In the non-local
electric field models, the avalanche probability and band-to-band
tunneling rate are different from the local models. DCR output is
evaluated in two different complementary metal oxide semiconductor
(CMOS) processes, of 0.15 μm and 0.18 μm. The
non-local avalanche probability is based on considering a non-local
dependence of impact ionization on the electric field. At high
electric fields, the local model predicts the ionization distance to
be negligible and therefore the avalanche probability was not
calculated accurately. The results show that the non-local model is
closer to the data obtained from the experiment than the local
model.
Depression Symptoms Moderate Associations between Daily Functioning and Neuropsychological Performance in Mexican American Adults
Authors: Graves Lisa V , Lozano Jennifer , Vergonia Lorraine , Ortega Paola 
Published: October 2024

Abstract

Objective
The influence of depression on the relationship between cognition and daily living in aging Mexican American adults requires further investigation, given projected trends in general growth as well as prevalence of depression and Alzheimer’s disease and related dementias (ADRD) in this population.

Method
In the present study, we examined the extent to which depression (assessed using the Geriatric Depression Scale – 15 item version) moderated the association between reported daily functioning (assessed using the Functional Activities Questionnaire [FAQ]) and objective neuropsychological performance in aging Mexican American adults in the National Alzheimer’s Coordinating Center cohort.

Results
Worse reported daily functioning (higher FAQ scores) was associated with worse memory and language performance among participants without elevated depression symptoms (ps &lt; .05), but no associations were observed among those with elevated symptoms (ps &gt; .05). Moreover, depression did not moderate associations of reported daily functioning with performance in attention and working memory or executive functioning and processing speed (ps &gt; .05).

Conclusions
Aging Mexican American adults with elevated depression symptoms may have subjective informant reports of daily functioning that are discrepant from their objective performance on formal tests of memory and language. Within the context of neuropsychological evaluations for ADRD, failure to adequately assess mood to inform the nature of cognitive and/or functional changes could result in misdiagnosis and lead to delayed, premature, and/or improper intervention with this population.
Wound Care at the Intersection of Race, Ethnicity, and Malnutrition
Authors: Munoz Nancy , Litchford Mary 
Published: October 2024

ABSTRACT
Ensuring adequate nutrition is vital for maintaining skin health and promoting successful wound healing. Globally, the rise in malnutrition and diet-related diseases is contributing to increased rates of illness and disability. Populations in food deserts and those experiencing food insecurity are particularly at risk. Being at risk for or having malnutrition associated with chronic conditions such as diabetes and cardiovascular disease can increase the incidence of wounds. Healthcare disparities and varied clinical outcomes among ethnic minorities further contribute to these challenges. Research indicates that racial and ethnic minorities experience a higher prevalence and severity of wounds, including pressure injuries. Detecting early-stage wounds in individuals with darker skin tones can be difficult, adding to the disparities.
Culturally appropriate nutrition interventions are essential in addressing these health inequities because tailored approaches tend to be more effective than uniform strategies. Understanding diverse dietary patterns and incorporating cultural food preferences into care plans can improve patient adherence and outcomes. Promoting equity in wound care through culturally sensitive practices helps to foster respect, dignity, and trust within healthcare settings, particularly for minority populations.
In this review, the authors highlight the need for inclusive interventions that provide culturally aligned nutrition, supporting patients' clinical and holistic well-being.
Comparison of RVU Reimbursement in Anterior or Posterior Approach for Single- and Multilevel Cervical Spinal Fusion
Authors: Asthana Shravan , Bajaj Pranav , Staub Jacob , Workman Connor , Khazanchi Rushmin , Reyes Samuel , Patel Alpesh A. , Hsu Wellington K. , Divi Srikanth N. 
Published: October 2024

Study Design:
Retrospective database study.

Objective:
This study aims to quantify and compare mean work RVUs (wRVUs), mean operative time (OpTime), and wRVUs/min in single- and multilevel anterior and posterior cervical spine fusions performed between 2011 and 2020.

Summary of Background Data:
Prior research has demonstrated inconsistencies in technical skill, operative time, and surgical difficulty with reimbursement in various orthopedic subspecialties. Although trends investigating physician effort and reimbursement have been investigated in lumbar spine surgery, less research has examined these relationships with respect to cervical spine procedures.

Methods:
The American College of Surgeons National Surgical Quality Improvement Program (NSQIP) was queried for Current Procedural Terminology (CPT) codes reflecting anterior cervical discectomy and fusion (ACDF), posterior cervical decompression and fusion (PCDF), and the number of levels involved. The cohort was stratified into 10 groups: single-level, 2-level, 3-level, 4-level, 5+ level anterior or posterior cervical fusions. Mean operative times, mean wRVUs, and wRVU/min were calculated and compared by Student t test.

Results:
A total of 100,997 patients met inclusion criteria in this study, of which 79,141 (78.36%) underwent ACDF, whereas 21,836 (21.62%) underwent PCDF. One- and 2-level fusions were most common in both ACDF and PCDF. In 1-, 3-, 4-, and 5+ level fusion, the anterior approach demonstrated significantly lower mean wRVU (P<0.001). In 1-, 2-, and 3-level fusions, the anterior approach had significantly lower operation times (P<0.001). The anterior approach demonstrated significantly higher wRVU/min in 1- and 2- levels (P<0.001) but lower wRVU/min in 3- and 4-level fusions (P<0.001).

Conclusions:
Clear discrepancies exist between surgical approach and levels of fusion in cervical spine procedures incongruous with markers of surgical difficulty, physician effort, or expertise required. These specific results suggest that the complexity of multi-level anterior cervical fusions are not effectively accounted for by existing RVU measures.
Piloting an Educational Module on Consenting for Exome Sequencing Among Non-Genetics Physicians at a Medical Institution
Authors: Chan Amanda K. , Bogyo Kelsie , Geltzeiler Alexa R. , Zhang Yuan , Ahimaz Priyanka 
Published: October 2024

Introduction:
Demand for genetic testing has expanded exome sequencing (ES) utilization into subspecialty clinics without genetics providers. This trend forces non-genetics physicians (NGPs) to facilitate patient consent for genetic testing. However, research on NGPs' knowledge of consent elements (CK) required for ES has not been explored.

Methods:
Columbia University NGPs were invited to take a survey (premodule survey [PrS]) assessing CK for ES. Educational modules on ES were then created and sent to NGP participants. A postmodule survey (PoS) was sent to NGPs a month later to assess the change in CK scores. Alpha was set at ≤0.05.

Results:
Nineteen participants completed the PrS and PoS. Overall PrS CK scores were low (mean = 8, SD 1.6). There was no difference in PrS CK scores between attendings and residents/fellows (P = .2), and PrS CK scores did not correlate with time since medical school graduation (P = .9). PoS CK scores were higher than PrS CK scores (P = .03). Most NGPs (74%) were satisfied with the module.

Conclusions:
Our findings suggest a need for continuing education of both new and experienced NGPs on best practices for consenting for ES. An online module with information tailored to different specialties could be an effective format for delivering this education.
Topical Platelet Exosomes Reduce Senescence Signaling in Human Skin: An Exploratory Prospective Trial
Authors: Wyles Saranya P. , Yu Grace T. , Gold Michael , Behfar Atta 
Published: October 2024

BACKGROUND
Cellular senescence, an irreversible cell cycle arrest with secretory phenotype, is a hallmark of skin aging. Regenerative exosome-based approaches, such as topical human platelet extract (HPE), are emerging to target age-related skin dysfunction.

OBJECTIVE
To evaluate the cellular and molecular effects of topical HPE for skin rejuvenation after 12 weeks of twice daily use.

METHODS
Skin biopsies were obtained for histological evaluation of senescence markers, p16INK4a and p21CIP1/WAF1. Telomere-associated foci, coassociation of telomeres, and DNA damage marker, γH2AX, were assessed. RNA sequencing evaluated senescence associated secretory phenotype (SASP) and extracellular matrix pathways.

RESULTS
p16INK4a and p21CIP1/WAF1 staining in senescent skin cells revealed low and high expression subgroups that did not correspond to chronological age. Topical HPE significantly reduced high p16INK4a cells in the dermis (p = .02). There was also a decrease in telomere damage after topical HPE (p = .03). In patients with high senescent cells at baseline, there was a 40% reduction in proinflammatory SASP. Extracellular matrix remodeling pathways, including collagen and elastic fibers, were up-regulated.

CONCLUSION
Topical HPE, applied on intact skin, reduced senescence signaling and senescence-associated telomere damage after 12 weeks of twice daily use, targeting a path for skin longevity or healthy skin aging.
Antibody–drug conjugates as targeted therapy for treating gynecologic cancers: update 2025
Authors: Silverstein Jordyn , Karlan Beth , Herrington Nasim , Konecny Gottfried 
Published: October 2024

Purpose of review
Provide the most up-to-date information on the dynamic landscape of antibody–drug conjugates (ADCs) in gynecologic cancers. We discuss the latest research that supports the approved ADCs and outline the ongoing trials and preliminary results that may lead to ADC approvals in the future. Current gaps in knowledge and areas for future research are discussed.

Recent findings
ADCs are rapidly changing the landscape of gynecologic cancer care. Three ADCs are currently FDA approved and used routinely in clinical practice, with many more currently in clinical development. The most common ADC target is folate receptor alpha of which there are 8 different folate receptor targeting ADCs in development. Other targets under investigation include trophoblast cell surface antigen-2 (Trop-2), claudin-6 (CLDN6), cadherin-6 (CDH6), nectin-4, HER-2 and B7-H4. ADCs can cause new and unique adverse effects, including ocular toxicities and interstitial lung disease.

Summary
ADCs offer the opportunity for a more effective and personalized treatment approach for gynecologic cancer patients. Side effects must be closely monitored, and preventive measures must be followed to maximize benefit and minimize toxicity. A better understanding of the role of target proteins as biomarkers to predict response to ADCs will be critical for successful clinical implementation of ADCs and further research in this area is necessary.
Fatigue, sleep disturbance, and pain interference in children and adolescents with chronic pain: a longitudinal study
Authors: Roman-Juan Josep , Ceniza-Bordallo Guillermo , Sánchez-Rodríguez Elisabet , Jensen Mark P. , Miró Jordi 
Published: October 2024

Abstract
Research has shown that pain and sleep disturbance often co-occur and influence each other over time in children and adolescents with chronic pain. Longitudinal studies examining the underlying mechanisms of this association are scarce and have focused primarily on the role of internalizing mental health symptoms and mood. This longitudinal study aimed to determine whether fatigue underlies the co-occurrence and mutual maintenance of sleep disturbance and pain over time in children and adolescents with chronic pain. Participants were 355 school-aged children and adolescents (mean age = 11.63 year old; 67% female) with chronic pain. The participants provided sociodemographic information and responded a survey that included measures of pain (duration, intensity, interference), sleep disturbance, and fatigue at first assessment and 12 months later. Partially latent, cross-lagged, panel, structural equation models revealed that sleep disturbance, pain intensity, and pain interference co-occurred at both time points. Higher levels of sleep disturbance, pain intensity, and pain interference at first assessment predicted higher levels of sleep disturbance, pain intensity, and pain interference at follow-up, respectively. Higher levels of pain interference at first assessment predicted higher levels of sleep disturbance at follow-up while controlling for initial levels of sleep disturbance. Furthermore, fatigue was found to mediate the association between first assessment and follow-up sleep disturbance, the association between first assessment and follow-up pain interference, and the association between first assessment pain interference and follow-up sleep disturbance. The findings highlight the need to assess and address fatigue in children and adolescents with chronic pain and sleep disturbance.