bluuebunny/crossref_metadata_2025_split huggingface dataset:
The state of framework development for implementing reasoning mechanisms in smart cyber-physical systems: A literature review
Authors: Tepjit Sirasak , Horváth Imre , Rusák Zoltán 
Published: April 2019

AbstractSmart CPSs (S-CPSs) have been evolving beyond what was identified by the traditional definitions of CPSs. The objective of our research is to investigate the concepts and implementations of reasoning processes for S-CPSs, and more specifically, the frameworks proposed for the fuzzy front end of their reasoning mechanisms. The objectives of the paper are: (i) to analyze the framework concepts and implementations of CPS, (ii) to review the literature concerning system-level reasoning and its enablers from the points of view of the processed knowledge, building awareness, reasoning mechanisms, decision making, and adaptation. Our findings are: (i) awareness and adaptation behaviors are considered as system-level smartness of S-CPSs that are not achieved by traditional design approaches; (ii) model-based and composability approaches insufficiently support the development of reasoning mechanisms for S-CPSs; (iii) frameworks for development of reasoning in S-CPS should support compositional design. Based on the conclusions above, we argue that coping with the challenges of compositionality requires both software-level integration and holistic fusion of knowledge by means of semantic transformations. This entails the need for a multi aspect framework that is able to capture at least conceptual, functional, architectural, informational, interoperation, and behavioral aspects. It needs further investigation if a compositionality enabling framework should appear in the form of a meta-framework (abstract) or in the form of a semantically integrated (concrete) framework.Highlights Smartness in CPSs is a holistic and synergistic behavioral characteristic. Complex mental representations are compositional. Compositionality is necessary for smart CPSs. Without a rigorous unifying framework, designing synthesis reasoning remains ad hoc.
Estimating the Attributable Disease Burden and Effects of Interhospital Patient Sharing on Clostridium difficile Infections
Authors: Sewell Daniel K. , Simmering Jacob E. , Justice Samuel , Pemmaraju Sriram V. , Segre Alberto M. , Polgreen Philip M. 
Published: April 2019

AbstractObjective:To estimate the burden of Clostridium difficile infections (CDIs) due to interfacility patient sharing at regional and hospital levels.Design:Retrospective observational study.Methods:We used data from the Healthcare Cost and Utilization Project California State Inpatient Database (2005–2011) to identify 26,878,498 admissions and 532,925 patient transfers. We constructed a weighted, directed network among the hospitals by defining an edge between 2 hospitals to be the monthly average number of patients discharged from one hospital and admitted to another on the same day. We then used a network autocorrelation model to study the effect of the patient sharing network on the monthly average number of CDI cases per hospital, and we estimated the proportion of CDI cases attributable to the network.Results:We found that 13% (95% confidence interval [CI], 7.6%–18%) of CDI cases were due to diffusion through the patient-sharing network. The network autocorrelation parameter was estimated at 5.0 (95% CI, 3.0–6.9). An increase in the number of patients transferred into and/or an increased CDI rate at the hospitals from which those patients originated led to an increase in the number of CDIs in the receiving hospital.Conclusions:A minority but substantial burden of CDI infections are attributable to hospital transfers. A hospital’s infection control may thus be nontrivially influenced by its neighboring hospitals. This work adds to the growing body of evidence that intervention strategies designed to minimize HAIs should be done at the regional rather than local level.
Postprandial incorporation of EPA and DHA from transgenic Camelina sativa oil into blood lipids is equivalent to that from fish oil in healthy humans
Authors: West Annette L. , Miles Elizabeth A. , Lillycrop Karen A. , Han Lihua , Sayanova Olga , Napier Johnathan A. , Calder Philip C. , Burdge Graham C. 
Published: April 2019

AbstractEPA and DHA are important components of cell membranes. Since humans have limited ability for EPA and DHA synthesis, these must be obtained from the diet, primarily from oily fish. Dietary EPA and DHA intakes are constrained by the size of fish stocks and by food choice. Seed oil from transgenic plants that synthesise EPA and DHA represents a potential alternative source of these fatty acids, but this has not been tested in humans. We hypothesised that incorporation of EPA and DHA into blood lipids from transgenicCamelina sativaseed oil (CSO) is equivalent to that from fish oil. Healthy men and women (18–30 years or 50–65 years) consumed 450 mg EPA + DHA from either CSO or commercial blended fish oil (BFO) in test meals in a double-blind, postprandial cross-over trial. There were no significant differences between test oils or sexes in EPA and DHA incorporation into plasma TAG, phosphatidylcholine or NEFA over 8 h. There were no significant differences between test oils, age groups or sexes in postprandial VLDL, LDL or HDL sizes or concentrations. There were no significant differences between test oils in postprandial plasma TNFα, IL 6 or 10, or soluble intercellular cell adhesion molecule-1 concentrations in younger participants. These findings show that incorporation into blood lipids of EPA and DHA consumed as CSO was equivalent to BFO and that such transgenic plant oils are a suitable dietary source of EPA and DHA in humans.
Management of subglottic stenosis in pregnancy using advanced apnoeic ventilatory techniques
Authors: Damrose E J , Manson L , Nekhendzy V , Collins J , Campbell R 
Published: April 2019

AbstractObjectiveTo describe the use of balloon dilation with non-invasive ventilation in the treatment of pregnant patients with idiopathic subglottic stenosis.MethodsThe medical charts of four consecutive patients who underwent jet ventilation or high-flow nasal cannula oxygenation with balloon dilation for the treatment of idiopathic subglottic stenosis during pregnancy were reviewed.ResultsObjective improvement of subglottic stenosis was seen in all four cases, with end-result Myer–Cotton grade 1 lesions down from pre-procedure grade 3 lesions. Patients also reported subjective improvements in symptomatology, with no further airway issues. All patients delivered normally, at term.ConclusionLaryngeal dilation with continuous radial expansion pulmonary balloons using non-invasive ventilation for the treatment of idiopathic subglottic stenosis in pregnant patients is safe and efficacious, and should be the first line treatment option for this patient population. The improvement in symptoms, and lack of labour and pregnancy complications, distinguish this method of treatment from others reported in the literature.
Activity of Thymus capitatus essential oil components against in vitro cultured Echinococcus multilocularis metacestodes and germinal layer cells
Authors: Hizem Amani , Lundström-Stadelmann Britta , M'rad Selim , Souiai Sawssen , Ben Jannet Hichem , Flamini Guido , Ascrizzi Roberta , Ghedira Kamel , Babba Hamouda , Hemphill Andrew 
Published: April 2019

AbstractThe essential oil (EO) of Thymus capitatus, seven fractions (F1–F7) obtained from silica gel chromatography, and several pure EO components were evaluated with respect to in vitro activities against Echinococcus multilocularis metacestodes and germinal layer (GL) cells. Attempts to evaluate physical damage in metacestodes by phosphoglucose isomerase (PGI) assay failed because EO and F1–F7 interfered with the PGI-activity measurements. A metacestode viability assay based on Alamar Blue, as well as transmission electron microscopy, demonstrated that exposure to EO, F2 and F4 impaired metacestode viability. F2 and F4 exhibited higher toxicity against metacestodes than against mammalian cells, whereas EO was as toxic to mammalian cells as to the parasite. However, none of these fractions exhibited notable activity against isolated E. multilocularis GL cells. Analysis by gas chromatography-mass spectrometry showed that carvacrol was the major component of the EO (82.4%), as well as of the fractions F3 (94.4%), F4 (98.1%) and F5 (90.7%). Other major components of EO were β-caryophyllene, limonene, thymol and eugenol. However, exposure of metacestodes to these components was ineffective. Thus, fractions F2 and F4 of T. capitatus EO contain potent anti-echinococcal compounds, but the activities of these two fractions are most likely based on synergistic effects between several major and minor constituents.
Technology-based parenting interventions for children's physical and psychological health: a systematic review and meta-analysis
Authors: Flujas-Contreras Juan M. , García-Palacios Azucena , Gómez Inmaculada 
Published: April 2019

AbstractBackgroundParenting interventions have important consequences for the wellbeing and emotional competences of parents and their children. Technology provides an opportunity with advantages for psychological intervention. The aim of this systematic review and meta-analysis is to analyze the characteristics and effectiveness of technology-based interventions for parents to promote children's physical health or psychological issues.MethodsWe conducted a systematic review and meta-analysis for articles about parenting skills for prevention or treatment of children's physical or psychological concerns using technology. We explore the aim of the intervention with parents, kind of problem with children, intervention model, instruments, methodological quality, and risk of bias. A random-effects meta-analysis was conducted.ResultsTwenty-four studies were included in the systematic review and a meta-analysis of 22 studies was performed to find out the effects of intervention depending on the kind of problem, intervention model, follow-up, type of intervention, type of control condition, and type of outcome data. Results show the usefulness of technology-based therapy for parenting interventions with moderate effect sizes for intervention groups with statistically significant differences from control groups.ConclusionsTechnology-based parenting programs have positive effects on parenting and emotional wellbeing of parents and children. Attendance and participation level in technology-based treatment increase compared with traditional parenting intervention.
Dirac States of 2D Topological Insulators: Effect of Heterovalent Dopant-Content
Authors: Khatun Salma , Pal Amlan J. 
Published: April 2019

AbstractWe have studied Bi2Se3 at its 2D-limit using scanning tunneling spectroscopy (STS). Bulk Bi2Se3 is a well-known topological insulator having gapless surface states. In the 2D limit, the interior of the material exhibits a band gap, whereas the periphery shows a gapless metallic state having a Dirac point. We demonstrate a method to tune the Fermi energy and hence the Dirac point of Bi2Se3 nanoplates through doping at the anionic site. For this purpose, STS measurements were carried out on the Bi2Se3 system. We have used bromide as a dopant, which turns the material to n-type in nature. As a result, STS studies infer that the Fermi energy (EF) shifted toward the conduction band and consequently the Dirac point could be found to move away from Fermi energy. Through STS measurements, we have demonstrated a correlation between the shift of Dirac point position and the dopant content. The size, shape, and compositions of Bi2Se3 nanoflakes and concentration of bromine in the doped nanostructures were determined using transmission electron microscopy, associated energy dispersive X-ray spectroscopy analysis, and X-ray diffraction.
Self-assessment of residents in respect of attitudes to communication
Authors: Kaya Rustu , Benli Ali Ramazan , Cebecik Aybala , Sunay Didem 
Published: April 2019

AbstractAimAs communication skills are essential for medical practice, many medical schools have added communication skills training to their curricula in recent years. The aim of this study was to determine and compare the attitudes to communication skills of family medicine, internal medicine and general surgery residents.Materials and methodsFamily medicine, internal medicine and general surgery residents of three training and research hospitals and one university hospital in Ankara were included in this cross-sectional study. A questionnaire was used for obtaining information about age, gender, marital status, graduation date and whether receiving any training for communication skills. The Turkish version of the Communication Skills Attitude Scale was used.ResultsIn all, 58 (50%) family medicine, 30 (25.9%) internal medicine, and 28 (24.1%) general surgery residents were accepted to participate in the study. Of the 116 residents, 58 (50%) were female and 58 (50%) were male, with a mean age of 29.47±4.63 years, and 68 (58.6%) of them were married; 59.5% of the participants received training about communication skills and 56.5% of them received it at medical school. The mean positive attitude scale (PAS) score was 3.85±0.58, and the mean negative attitude scale (NAS) score was 2.42±0.52. The PAS scores of female residents were higher than those of males (P=0.01). The PAS scores of residents who received communication skills training were higher than the scores of those who had not (P=0.01). The PAS scores of family medicine residents were higher and the NAS scores were lower than those of internal medicine and general surgery residents.ConclusionThe communication skill attitudes of family medicine residents were better than those of internal medicine and general surgery residents.
Paradigms in operation: explaining pharmaceutical benefit assessment outcomes in England and Germany
Authors: Kieslich Katharina 
Published: April 2019

AbstractHealth technology assessments (HTAs) are used as a policy tool to appraise the clinical value, or cost effectiveness, of new medicines to inform reimbursement decisions in health care. As HTA organisations have been established in different countries, it has become clear that the outcomes of medicine appraisals can vary from country to country, even though the same scientific evidence in the form of randomised controlled trials is available. The extant literature explains such variations with reference to institutional variables and administrative rules. However, little research has been conducted to advance the theoretical understanding of how variations in HTA outcomes might be explained. This paper compares cases of HTA in England and Germany using insights from Kuhn (1962,The Structure of Scientific Revolutions, 2nd edn. Chicago: The University of Chicago Press) and Hall (1993, Policy paradigms, social learning, and the state: the case of economic policymaking in Britain.Comparative Politics25, 275–296) to demonstrate how policy paradigms can explain the outcomes of HTA processes. The paper finds that HTA outcomes are influenced by a combination of logical issues that require reasoning within a paradigm, and institutional and political issues that speak to the interaction between ideational and interest-based variables. It sets out an approach that advances the theoretical explanation of divergent HTA outcomes, and offers an analytical basis on which to assess current and future policy changes in HTA.
Modulation of Locally Generated Equatorial Noise by ULF Wave
Authors: Zhu Hui , Chen Lunjin , Liu Xu , Shprits Yuri Y. 
Published: April 2019

AbstractIn this paper we report a rare and fortunate event of fast magnetosonic (MS, also called equatorial noise) waves modulated by compressional ultralow frequency (ULF) waves measured by Van Allen Probes. The characteristics of MS waves, ULF waves, proton distribution, and their potential correlations are analyzed. The results show that ULF waves can modulate the energetic ring proton distribution and in turn modulate the MS generation. Furthermore, the variation of MS intensities is attributed to not only ULF wave activities but also the variation of background parameters, for example, number density. The results confirm the opinion that MS waves are generated by proton ring distribution and propose a new modulation phenomenon.
Morphodynamics of River Deltas in Response to Different Basin Water Depths: An Experimental Examination of the Grade Index Model
Authors: Wang Junhui , Muto Tetsuji , Urata Kento , Sato Toshihiko , Naruse Hajime 
Published: April 2019

AbstractBasin water depth (h) governs the long‐term morphodynamics of river deltas, which are embodied in the grade index (Gindex). The Gindex, a volume‐in‐unit‐time ratio of subaerial sediment allocation to the entire supplied sediment, can be given as a function of the dimensionless basin water depth (h*). Tank experiments reported herein reveal that delta progradation and deltaplain aggradation are suppressed and distributary channel migration and avulsion take place less frequently when the Gindex value is lower (i.e., when the basin water is deeper; h* ≫ 1). If the Gindex~0 (i.e., extremely deep basin water; h*~+∞), the delta can neither prograde nor aggrade, and the distributary channels tend to stabilize. The grade index model helps explain the contrasting morphodynamics of the Liwu Delta (east Taiwan) and Yellow River Delta, as natural examples of deepwater and shallow‐water deltas, respectively.
Connectome analysis of functional and structural hemispheric brain networks in major depressive disorder
Authors: Jiang Xueyan , Shen Yuedi , Yao Jiashu , Zhang Lei , Xu Luoyi , Feng Rui , Cai Liqiang , Liu Jing , Chen Wei , Wang Jinhui 
Published: April 2019

AbstractNeuroimaging studies have shown topological disruptions of both functional and structural whole-brain networks in major depressive disorder (MDD). This study examined common and specific alterations between these two types of networks and whether the alterations were differentially involved in the two hemispheres. Multimodal MRI data were collected from 35 MDD patients and 35 healthy controls, whose functional and structural hemispheric networks were constructed, characterized, and compared. We found that functional brain networks were profoundly altered at multiple levels, while structural brain networks were largely intact in patients with MDD. Specifically, the functional alterations included decreases in intra-hemispheric (left and right) and inter-hemispheric (heterotopic) functional connectivity; decreases in local, global and normalized global efficiency for both hemispheric networks; increases in normalized local efficiency for the left hemispheric networks; and decreases in intra-hemispheric integration and inter-hemispheric communication in the dorsolateral superior frontal gyrus, anterior cingulate gyrus and hippocampus. Regarding hemispheric asymmetry, largely similar patterns were observed between the functional and structural networks: the right hemisphere was over-connected and more efficient than the left hemisphere globally; the occipital and partial regions exhibited leftward asymmetry, and the frontal and temporal sites showed rightward lateralization with regard to regional connectivity profiles locally. Finally, the functional–structural coupling of intra-hemispheric connections was significantly decreased and correlated with the disease severity in the patients. Overall, this study demonstrates modality- and hemisphere-dependent and invariant network alterations in MDD, which are helpful for understanding elaborate and characteristic patterns of integrative dysfunction in this disease.
Structure elucidation and proposed de novo synthesis of an unusual mono-rhamnolipid by Pseudomonas guguanensis from Chennai Port area
Authors: Ramya Devi K. C. , Sundaram R. Lakshmi , Vajiravelu Sivamurugan , Vasudevan Vidya , Mary Elizabeth Gnanambal K. 
Published: April 2019

AbstractIn this paper, we describe the isolation of an unusual type of high molecular weight monorhamnolipid attached to esters of palmitic, stearic, hexa and octadecanoic acids as against the routinely reported di-rhamnolipids linked to hydroxydecanoic acids. The bioemulsifier was column-purified and the chemical nature of the compound was elucidated using FT-IR, GC-MS and 1D [1H and13C] and 2D NMR. This monorhamnolipid is extracted from a bacterium, Pseudomonas guganensis and is not reported to have biological activities, let alone emulsification abilities. The bacterium continually produced rhamnolipids when nourished with n-hexadecane as its lone carbon source. The extracellularly secreted monorhamnolipids are capable of degrading hydrocarbons, with most preference to n-hexadecane [EI24 of 56 ± 1.42% by 2 mL of the spent medium]. Whilst the crude ethyl acetate partitioned extract had an EI24 of 65 ± 1.43%; the purified rhamnolipid product showed 78 ± 1.75% both at 12.5 mg/mL concentration. The used-up n-hexadecane is biotransformed to prepare its own rhamnolipids which in return is utilized to degrade n-alkanes thus creating a circular pathway which is proposed herein. This bacterium can be seen as a new source of bioemulsifier to reduce hydrocarbon in polluted waters.
Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via Hypothalamic Urocortin 1 in Mice
Authors: Suzuki Hajime , Ataka Koji , Asakawa Akihiro , Cheng Kai-Chun , Ushikai Miharu , Iwai Haruki , Yagi Takakazu , Arai Takeshi , Yahiro Kinnosuke , Yamamoto Katsuhiro , Yokoyama Yoshito , Kojima Masayasu , Yada Toshihiko , Hirayama Toshiya , Nakamura Norifumi , Inui Akio 
Published: April 2019

AbstractHelicobacter pylori (Hp) infection is related to the pathogenesis of chronic gastric disorders and extragastric diseases. Here, we examined the anorexigenic and anxiogenic effects of Hp vacuolating cytotoxin A (VacA) through activation of hypothalamic urocortin1 (Ucn1). VacA was detected in the hypothalamus after peripheral administration and increased Ucn1 mRNA expression and c-Fos-positive cells in the hypothalamus but not in the nucleus tractus solitarius. c-Fos and Ucn1-double positive cells were detected. CRF1 and CRF2 receptor antagonists suppressed VacA-induced anxiety and anorexia, respectively. VacA activated single paraventricular nucleus neurons and A7r5 cells; this activation was inhibited by phospholipase C (PLC) and protein kinase C (PKC) inhibitors. VacA causes anorexia and anxiety through the intracellular PLC-PKC pathway, migrates across the blood-brain barrier, and activates the Ucn1-CRF receptor axis.
Changes in the Canine Plasma Lipidome after Short- and Long-Term Excess Glucocorticoid Exposure
Authors: Sieber-Ruckstuhl Nadja S. , Burla Bo , Spoerel Susanne , Schmid Florence , Venzin Claudio , Cazenave-Gassiot Amaury , Bendt Anne K. , Torta Federico , Wenk Markus R. , Boretti Felicitas S. 
Published: April 2019

AbstractGlucocorticoids (GCs) are critical regulators of metabolic control in mammals and their aberrant function has been linked to several pathologies. GCs are widely used in human and veterinary clinical practice as potent anti-inflammatory and immune suppressive agents. Dyslipidaemia is a frequently observed consequence of GC treatment, typified by increased lipolysis, lipid mobilization, liponeogenesis, and adipogenesis. Dogs with excess GC show hyperlipidaemia, hypertension, and a higher risk of developing type 2 diabetes mellitus, but the risk of developing atherosclerotic lesions is low as compared to humans. This study aimed to examine alterations in the canine plasma lipidome in a model of experimentally induced short-term and long-term GC excess. Both treatments led to significant plasma lipidome alterations, which were more pronounced after long-term excess steroid exposure. In particular, monohexosylceramides, phosphatidylinositols, ether phosphatidylcholines, acyl phosphatidylcholines, triacylglycerols and sphingosine 1-phosphates showed significant changes. The present study highlights the hitherto unknown effects of GCs on lipid metabolism, which will be important in the further elucidation of the role and function of GCs as drugs and in metabolic and cardiovascular diseases.