bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of inflammation and nutrition-based indicators with chronic obstructive pulmonary disease and mortality
Authors: Cao Kaiqiang , Miao Xiaoyang , Chen Xiaorong 
Published: December 2024

Abstract
Background
Inflammation and nutrition are strongly linked to respiratory diseases, but the link between inflammation and nutrition-based indicators and chronic obstructive pulmonary disease (COPD) and its mortality has not been reported.

Methods
We recruited adults no younger than 20 years old from the NHANES 1999–2018. Inflammation and nutrition-based indicators included NAR, PNI, MAR, RAR, HALP, and ALI. COPD were assessed through a self-report questionnaire. Participants’ mortality rates were determined by association with the National Death Index.

Results
A total of 46,572 individuals were collected in this study, including 1,549 COPD patients. NAR, MAR, and RAR were positively linked with the prevalence of COPD. However, PNI and HALP were negatively linked with the prevalence of COPD. In participants with COPD, the highest quartile of NAR (HR = 1.43 [1.04–1.97]), MAR (HR = 1.66 [1.23–2.26]), and RAR (HR = 2.45 [1.90–3.17]) were linked with an increased risk of all-cause mortality compared to the lowest quartile. However, the highest quartile of PNI (HR = 0.48 [0.38–0.61]) and HALP (HR = 0.56 [0.44–0.71]) were linked with a decreased risk of all-cause mortality compared to the lowest quartile. Randomized survival forests (RSF) showed that RAR had the strongest predictive power for all-cause mortality in COPD individuals among all indicators.

Conclusion
We found that inflammation and nutrition-based indicators were linked to prognosis in COPD patients, with RAR having the highest predictive value.
Symptom Monitoring App Use Associated With Medication Adherence Among Woman Survivors of Breast Cancer on Adjuvant Endocrine Therapy
Authors: Krukowski Rebecca A. , Hu Xin , Arshad Sara , Anderson Janeane N. , Stepanski Edward , Vidal Gregory A. , Schwartzberg Lee S. , Graetz Ilana 
Published: December 2024

PURPOSE
Oral adjuvant endocrine therapy (AET) reduces the risk of cancer recurrence and death for women with hormone receptor–positive (HR+) breast cancer. Because of adverse symptoms and socioecologic barriers, AET adherence rates are low. We conducted post hoc analyses of a randomized trial of a remote symptom and adherence monitoring app to evaluate characteristics associated with higher app use, satisfaction, and how app use was associated with AET adherence.

METHODS
Patients prescribed AET were randomly assigned to receive one of three intervention conditions: app, app + feedback, or enhanced usual care. Baseline and 6-month follow-up surveys, app use, and pillbox-monitored AET adherence data for app and app + feedback participants were used. Logistic regression evaluated the association between sociodemographic/clinical characteristics and app utilization and satisfaction, and how app use was associated with AET adherence (>80%).

RESULTS

Overall, 163 women with early-stage HR+ breast cancer were included; 35.0% had high app use (≥75% of weeks enrolled). No sociodemographic characteristics were associated with app use. Satisfaction with the app was higher among those who were younger (88.9% for age 31-49 years
v
54.9% for age 65+ years,
P
< .001), identified as White (76.8%
v
60.1% for Black,
P
= .045), had lower health literacy (85.4%
v
68.2% with higher health literacy,
P
= .017), or were nonurban residents (85.7%
v
68.6% for urban,
P
= .021). Most participants (90.3%) with high app use were AET-adherent compared with 66.8% for those with lower app use (
P
< .001).

CONCLUSION
Use of a remote monitoring app was similar across sociodemographic characteristics, and more frequent app use was associated with a higher likelihood of 6-month AET adherence. Encouraging women to monitor medication adherence and communicate adverse symptoms could improve AET adherence.
Circulating Tumor DNA as a Prognostic Biomarker for Recurrence in Patients With Locoregional Esophagogastric Cancers With a Pathologic Complete Response
Authors: Lander Eric Michael , Aushev Vasily N. , Huffman Brandon M. , Hanna Diana , Dutta Punashi , Ferguson Jenifer , Sharma Shruti , Jurdi Adham , Liu Minetta C. , Eng Cathy , Klempner Samuel J. , Gibson Michael K. 
Published: December 2024

PURPOSE
After neoadjuvant therapy (NAT) and surgery, up to one third and one half of patients with esophagogastric adenocarcinoma with a pathologic complete response (pCR; tumor regression grade 0 [TRG-0]) and near-pCR (TRG-1) will recur, respectively. Our study aims to evaluate postoperative circulating tumor DNA (ctDNA) as a predictor of recurrence in patients with pCR or near-pCR after curative-intent neoadjuvant chemotherapy or neoadjuvant chemoradiation and surgery.

METHODS
We retrospectively identified patients from 11 institutions with stages I-IV esophagogastric cancers (EGCs) who completed NAT and had TRG-0/1 scores at the time of curative-intent surgery. Postoperative plasma samples were collected for ctDNA analysis within a 16-week molecular residual disease (MRD) window after definitive surgery, and during surveillance from January 7, 2020, to November 9, 2023, at the provider's discretion. ctDNA was assessed using a clinically validated, personalized, tumor-informed ctDNA assay (Signatera, Natera, Inc). The primary outcome was recurrence-free survival (RFS).

RESULTS

We obtained 309 blood samples from 42 patients with esophagogastric adenocarcinoma with a pCR after neoadjuvant treatment over a median follow-up time of 28.5 months (range, 0.2-81.7). Detectable ctDNA in the 16-week MRD window (N = 23) correlated with higher rates of recurrence (67%; 2/3) compared with undetectable ctDNA (15%; 3/20). Detectable ctDNA within the MRD window was associated with a significantly shorter RFS (hazard ratio [HR], 6.2;
P
= .049). Among 32 patients who had ctDNA analyzed in the surveillance setting, the recurrence rate was 100% (5/5) in the ctDNA-positive cohort compared with 7.4% (2/27) in ctDNA-negative patients and was associated with shorter RFS (HR, 37.6;
P
< .001).

CONCLUSION
Within the subgroup of patients with EGC and favorable pathologic responses (TRG 0-1) after NAT, the presence of postoperative ctDNA identified patients with elevated recurrence risk.
Thought Experiments, Literary Fiction, and Science Fiction: The Example of Isaac Asimov's Robot Cycle
Authors: Bartolotta Simona 
Published: December 2024

Abstract
Literary cognitivism can be broadly defined as the claim that literary texts can be a source of knowledge. This article proposes the concept of aimless argumentativity to denote a paradoxical epistemic activity performed by fictional narratives. This concept is conceptualized and explored through an engagement with recent philosophical work on the epistemology of thought experiments and their similarities, or lack thereof, with literary fiction. These points are then illustrated through examples drawn from science fiction, and specifically Isaac Asimov's Robot series, which deploys its thought-experimental character in a specific form of nonlinear seriality, thus providing a clear and articulated demonstration of the oxymoronic, aimlessly argumentative power of fictional texts.
Writing as Deletion, Erasure as Inscription: Life, Death, and Afterlife in Sayed Kashua's Track Changes
Authors: Makhoul Manar H. 
Published: December 2024

Abstract
Stepping beyond prior analyses of Sayed Kashua's work, this article examines his most recent novel Track Changes (2017) as a turning point in his career. It reveals a shift in his relationship with Hebrew and his engagement with Palestinian memory, both personal and collective. Read from the perspective of contemporary Palestinian literature, Track Changes emerges as a powerful indictment of Jewish-Israeli indifference to the Palestinian fear of erasure and discontinuity.
Gerenciando a colaboração entre organizações
Authors: Costa Souza Fontenelle Sily de Assis Mariela , Wood Jr. Thomaz 
Published: December 2024

Objetivo: contribuir para um melhor entendimento sobre a colaboração entre organizações assimétricas no ecossistema de inovação e alertar para aspectos do lado sombrio desses relacionamentos, apresentando um framework com dimensões importantes a serem observadas nessas colaborações.
Estado da arte: os estudos científicos sobre o tema da colaboração interorganizacional ajudam a compreender seus motivadores, processos e impactos, e a identificar fatores de sucesso e de fracasso.
Originalidade: este artigo apresenta um framework para aplicação prática, reunindo aspectos ligados ao gerenciamento da colaboração entre organizações, assim como às manifestações do lado sombrio desses relacionamentos.
Impacto: o framework proposto pode ajudar os gestores na compreensão da dinâmica da colaboração entre organizações e suas armadilhas, contribuindo para um gerenciamento mais efetivo dessas associações.
The influence of mindfulness training in virtual reality on symptom severity and cognitive functioning of patients with schizophrenia and schizoaffective psychosis – a case series pilot study
Authors: Plencler Iga , Radoń Stanisław , Cechnicki Andrzej , Stankiewicz Przemysław , Daren Artur , Kalisz Aneta , Błądziński Piotr , Siwek Marcin 
Published: December 2024

Cel pracyOcena metodą idiograficzną skuteczności włączenia treningu uważności w wirtualnej rzeczywistości do terapii pacjentów z zaburzeniami z kręgu schizofrenii (Mindfulness Skills Training in Virtual Reality, MST -VR) i jej porównanie z wynikami analizy efektów grupowych.Metoda25 pacjentów chorujących na schizofrenię i psychozę schizoafektywną oceniono w odstępach 4-tygodniowych: miesiąc przed treningiem, w chwili rozpoczęcia i po jego zakończeniu za pomocą: Positive and Negative Syndrome Scale (PANSS–6), Quick Inventory of Depressive Symptomatology (QIDS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), State-Trait Anxiety Inventory (STAI), Perceived Stress Scale (PSS-10) oraz Addenbrooke’s Cognitive Examination III (ACE-III). Do oceny statystycznej wykorzystano rzetelny wskaźnik zmiany (ang. Reliable Change Index, RCI), a do oceny wielkości efektu wskaźnik d Cohena.WynikiWiększość pacjentów (20 osób, 80%) osiągnęła poprawę w zakresie nasilenia objawów ogólnych, pozytywnych, negatywnych, stresu, lęku, depresji oraz funkcjonowania poznawczego. U pojedynczych pacjentów zaobserwowano pogorszenie w zakresie lęku (2 osoby, 8%) i stresu (1 osoba,4%). Metoda RCI wykazała większą czułość w wykrywaniu zmian niż standardowe monograficzne metody statystyczne.WnioskiInterwencja MST-VR jako wspomagająca leczenie pacjentów z zaburzeniami z kręgu schizofrenii jest bezpieczna i korzystna. Metoda RCI jest wartościowa w ocenie dynamiki indywidualnych wyników pacjentów.
Medical emergencies in primary dental practice
Authors: Huxley Emma , Randell Leigh-Ann , McKernon Sarah 
Published: December 2024

Background: Medical emergencies can and do present in primary care dental practices. Approximately 60% of dentists experience at least one emergency a year. This article was prompted by several recent interactions; one being an anaphylaxis where the responding paramedics were unfamiliar with dental therapists and, most recently, where first responders were unfamiliar with the availability of oxygen within a primary dental practice. Aims: This article aims to enhance paramedics’ knowledge of dental team members that may be present, their scope of practice, what qualifications they may have, what equipment is available, what drugs can be administered and the most frequently presenting medical emergencies. Methods: This article reviews and consolidates medical emergency guidance and regulations for primary dental practice. Findings: There is limited guidance concerning what drugs dental care professionals can and cannot administer during a medical emergency. Going forward, additional guidance from regulators is needed. Conclusion: Responding emergency services need to be aware of all dental professionals they may encounter as well as their qualifications and limitations to ensure patients receive gold standard care.
Modelling the leadership role of police in controlling COVID-19
Authors: Singh Vikram , Kapoor Shikha , Gupta Sandeep kumar , Sharma Sandeep 
Published: December 2024

Abstract
During the recent Coronavirus disease (COVID-19) pandemic, different parts of the globe faced indefinite lockdowns. To maintain the lockdown measures, government authorities deployed security forces and police. The primary role of the police is to monitor the movement of the people and advise/guide them to follow the lockdown. In the current work, we propose a nonlinear mathematical model to study the role of police and security personnel in controlling COVID-19. It is observed that the proposed model possesses two equilibria, namely, trivial and non-trivial. We performed the stability analysis of the non-trivial equilibrium point by using the compound matrix technique. Finally, we perform a detailed numerical simulation to investigate the feasibility of the theoretical results. The current study demonstrates that police forces played a significant role in controlling the pandemic.
The importance of the cerebro-placental ratio at term for predicting adverse perinatal outcomes in appropriate for gestational age fetuses
Authors: Josten Hannah , Heimann Yvonne , Lehmann Thomas , Schleußner Ekkehard , Groten Tanja , Weschenfelder Friederike 
Published: December 2024

Abstract

Objectives
This study investigates the relationship between the cerebro-placental ratio (CPR) measured at 40+0 weeks’ gestation and perinatal outcomes to determine a CPR cut-off that may justify induction of labor at term in appropriately grown fetuses (AGA). Although CPR is used for monitoring growth-restricted fetuses, its role in guiding labor induction decisions for AGA pregnancies at term remains unclear.

Methods
A retrospective cohort study was conducted using data from 491 singleton pregnancies with intended vaginal deliveries between 2015 and 2021. CPR was assessed at the actual estimated date of delivery (40+0 weeks’ gestation). Adverse Pregnancy Outcome (APO) as the primary endpoint was defined by admission to neonatal intensive care unit (NICU), umbilical cord blood pH<7.1, 5-min APGAR<7 or interventions-due-to-fetal-distress during labor (IDFD=vaginal-operative delivery or emergency caesarean section).

Results
APO nearly doubled (adjOR 1.7; CI 1.007–2.905) when CPR was below our calculated cut-off of 1.269 (18.4 vs. 32.3 %, p=0.002) and NICU admissions (4.8 vs. 11.1 %, p=0.020) and IDFD (12.5 vs. 21.2 %, p=0.027) significantly increased. The positive predictive value for the presence of APO using our cut-off was 32.4 %, and the negative predictive value 81.6 %.

Conclusions
Our data confirm a predictive value of a reduced CPR at term with impaired perinatal outcome. The cut-off of CPR<1.269 may guide decision-making regarding induction of labor. Further prospective studies are needed to confirm these findings.
Analgesic effect of external oblique intercostal block in laparoscopic cholecystectomy: A retrospective study
Authors: Yi Shuai , Li Dan , Zhang Xin-lei , Duan Fen-yu , Gao Han , Kong Ming-jian 
Published: December 2024

Abstract

Objective
The aim of this study was to assess the impact of the external oblique intercostal block (EOIB) on early postoperative pain in patients who underwent laparoscopic cholecystectomy.

Methods
120 patients were divided into two groups: the EOIB group (Group E) and the control group (Group C). The assessed variables were mainly intraoperative remifentanil usage, numerical rating scale (NRS) pain scores at 0, 1, 2, 4, 6, 12, and 24 h postoperatively, cumulative fentanyl consumption within 24 h postoperatively and within the first-hour post-anesthesia care unit.

Results
Remifentanil consumption during surgery was significantly reduced in Group E compared to Group C. Postoperative fentanyl requirements were also lower in Group E at 1 and 24 h after surgery. Furthermore, Group E demonstrated significantly lower NRS scores at 0, 1, 2, 4, and 6 h postoperatively and a reduced need for rescue analgesia compared to Group C. However, at 12 h post-surgery, Group E’s NRS scores were slightly higher than Group C’s.

Conclusion
The EOIB is associated with reduced pain within the first 24 postoperative hours following laparoscopic cholecystectomy.
The crystal structure of diphenyl bis(2-((diphenoxyphosphoryl)amino)ethyl)phosphoramidate monohydrate C40H42N3O10P3
Authors: Du Chao-Jun , Cai Bin , Li Dan-Xia 
Published: December 2024

Abstract
C40H42N3O10P3, monoclinic, P21 (no. 4), a = 9.1649(2) Å, b = 17.1144(3) Å, c = 13.3495(3) Å, β = 109.548(2)°, V = 1973.20(7) Å3, Z = 2, R

gt
(F) = 0.0559, wR

ref
(F
2) = 0.1505, T = 99.99(10) K.
EM DIREÇĀO A UMA CRÍTICA DO SUJEITO MODERNO: EXPLORANDO OS CONCEITOS DE INCONSCIENTE EM FREUD E O DE MEMÓRIA EM AGOSTINHO
Authors: Da Cunha Mariana Paolozzi Sérvulo , de Souza Nunes Marcus Vinicius 
Published: December 2024

Embora a distância temporal entre Agostinho e Freud possa apresentar dificuldades no que se refere a aproximações conceituais, a tentativa deste artigo é reconhecer alguns conjuntos significantes que se estruturam em torno principalmente das noções de memória e de inconsciente. A finalidade de tal procedimento é identificar no que poderíamos chamar de uma antropologia, seja ela agostiniana ou freudiana, elementos para a crítica do sujeito da modernidade. Assim, serāo examinados o conceito de inconsciente freudiano e o de memória agostiniana e a sua referência a conteúdos latentes da mente, para em seguida ser pontuado o diferencial da memória agostiniana como sede de sabedoria e de transcendência, ideia ausente na teoria freudiana. Enquanto em Freud o sujeito fica desabrigado de si, não sendo senhor da própria casa, em Agostinho verifica-se a saída-de-si em direção a um ‘eu’ mais que ‘eu’. Ambos os autores se dedicam a investigar dimensões ocultas e desconhecidas da subjetividade, buscando lhes atribuir alguma inteligibilidade. Com isso explicitam-se elementos para uma crítica dessa “invenção “da modernidade, isto é, o sujeito tido como autossuficiente e autocentrado.
An ultra-fast validated green UPLC-MS/MS approach for the evaluation of zanubrutinib in vitro metabolic stability in human liver microsomes: Screening for in silico metabolic lability, ADME parameters, and DEREK toxic alerts
Authors: Attwa Mohamed W. , Abdelhameed Ali S. , Kadi Adnan A. 
Published: December 2024

AbstractZanubrutinib (Brukinsa, BeiGene) is a FAD approved second-generation Bruton's tyrosine kinase inhibitor that has more selectivity and reduced off-target action, resulting in mitigated cardiotoxicity compared to ibrutinib. The target of this investigation was to establish a fast, precise, green, and extremely sensitive UPLC-MS/MS approach for quantifying the level of zanubrutinib (ZNB) in human liver microsomes (HLMs). The separation of ZMB and revumenib was achieved using C8 column and isocratic gradient of the mobile phase. The linearity of the constructed ZNB calibration curve was ranged from 1 to 3,000 ng mL−1. The StarDrop software package including DEREK and WhichP450 modules was used in screening for the toxic alerts the in silico metabolic lability of ZNB. The AGREE score was 0.76 that approves the greenness of the established method. The low in vitro t1/2 (17.61 min) and high intrinsic clearance (46.03 mL min−1 kg−1) of ZNB revealed that ZNB shares similarities with medications that have a high extraction ratio. The present LC-MS/MS approach is considered the first analytical methodology for assessment of ZNB metabolic stability in HLMs matrix. In silico data from WhichP450 and DEREK modules suggest that making small structural changes (bioisosteric replacement) to the carboxamide moiety during drug design can potentially improve the metabolic safety and stability of novel compounds relative to ZNB. These methods are essential for advancing the development of new pharmaceuticals, particularly in enhancing metabolic stability.
Calidad del servicio y satisfacción del cliente en una Panificadora del Cono Este de Lima, 2023
Authors: Montenegro Piedra Yadira Anabela , Quispe Vilcapuma Rosa Elena , Cotacallapa Subia Luis Eddie 
Published: December 2024

Esta investigación tiene por objetivo identificar la relación existente entre la calidad del servicio y la satisfacción del cliente en una Panificadora del Cono Este de Lima. La investigación se realizó desde el enfoque de un estudio cuantitativo, descriptivo y correlacional causal; con un diseño no experimental y transversal. La muestra estuvo conformada por 258 clientes y los instrumentos utilizados fueron el modelo SERVQUAL para medir la calidad del servicio y las dimensiones de Kotler para medir la satisfacción del cliente. Los resultados revelaron que existe una relación alta, directa y significativa entre la calidad del servicio y la satisfacción del cliente (r = 0.88; p = .000 < 0.05), los elementos tangibles (r = 0.82; p = .000 < 0.05), confiabilidad (r = 0.79; p = .000 < 0.05), capacidad de respuesta (r = 0.80; p = .000 < 0.05), seguridad (r = 0.83; p = .000 < 0.05), y empatía (r = 0.8; p = .000 < 0.05) tienen una relación con la satisfacción del cliente. También se encontró que la calidad del servicio tiene un efecto significativo sobre la satisfacción del cliente alcanzando β=0.94 con un p valor de 0.000. Se concluye que la calidad del servicio y la satisfacción del cliente no solo guarda una relación, sino que la calidad del servicio tiene un efecto significativo sobre la satisfacción del cliente; por lo tanto, a mayor calidad de servicio se puede percibir mayor satisfacción en los clientes.
Analyzing the Impact of an 8-Week Structured Physical Activity Program on Health-Related Fitness in Bhutanese Seventh-Grade Students
Authors: Lhendup Gayley , Savagpun Pufa , Tiaotrakul Arphat 
Published: December 2024

Objectives. This study aimed to evaluate the impact of an 8-week physical activity program (PAP) on health-related fitness (HRF) components of seventh graders in Bhutan. Its emphasis areas included assessing the program’s effects on cardiorespiratory endurance, muscular strength, muscular endurance, flexibility, and body composition.
Materials and methods. Sixty-two students were allocated into two groups using simple random sampling: a control group (n = 31) following the standard physical education curriculum and an experimental group (n = 31) participating in the PAP utilizing the FITT (frequency, intensity, time, and type) principle. Fitness Gram assessments were used to measure HRF before implementing the intervention. Independent t-tests were used to compare results between groups, whereas paired t-tests were used to compare pre-test and post-test scores within groups.
Results. All HRF components demonstrated notable improvements in the experimental group. Cardiorespiratory endurance increased from a mean of 23.23 to 30.57 (p < 0 .05), muscular strength — from 7.47 to 12.37 (p < 0.05), muscular endurance — from a mean of 10.10 to 16.40 (p < 0.05), and flexibility — from 27.98 to 29.85 (p < 0.05). It was additionally observed an improvement in body composition, with a notable decline in BMI. Conversely, the control group showed a less significant decrease in flexibility and BMI, while demonstrating marked enhancements in cardiorespiratory endurance, muscular strength, and muscular endurance.
Conclusions. The study indicates that the organized PAP was more effective than the standard physical education curriculum in improving HRF components. These findings suggest that the implementation of structured PA programs using the FITT principles can lead to enhanced physical fitness and health-related outcomes among children and young people.