bluuebunny/crossref_metadata_2025_split huggingface dataset:
Authoring tools for creating 360 multisensory videos—Evaluation of different interfaces
Authors: Coelho Hugo , Melo Miguel , Barbosa Luís , Martins José , Teixeira Mário Sérgio , Bessa Maximino 
Published: May 2019

AbstractAuthoring 360 multisensory videos is a true challenge as the authoring tools available are scarce and restrictive. In this paper, we propose an authoring tool with three different authoring interfaces (desktop, immersive, and tangible interface) for creating multisensory 360 videos with the advantage of having a live preview of the multisensory content that is being produced. An evaluation of the three authoring tools having into account gender, system usability, presence, satisfaction, and effectiveness (time to accomplish tasks, number of errors, and number of help requests) is presented. The sample consisted of 48 participants (24 males and 24 females) evenly distributed between the different interfaces (8 males and 8 females for each interface).The results revealed that gender does not have any impact in the studied interfaces regarding all the dependent variables; immersive and tangible interfaces have higher levels of satisfaction than desktop interface as it allows more interaction freedom, and desktop interface have the lowest time to accomplish the tasks because people are more familiar with keyboard and mouse.
Predictors of developing a new need for long‐term care of older adults aged ≥70 years: Results from a population‐based cohort study in Taiwan
Authors: Hsu Wei‐Chung , Wang Jiun‐Yi , Tsai Alan C 
Published: May 2019

AimTo determine the characteristics associated with developing a new need for long‐term care among older Taiwanese adults.MethodsWe analyzed the 1999 and 2003 datasets of the Taiwan Longitudinal Survey on Aging. A total of 1986 persons who were aged ≥70 years and had no disability in activities of daily living or need for long‐term care at the baseline served as the study participants. We first identified the potential variables associated with developing a need for long‐term care in demographic, socioeconomic, anthropometric, functional status, mental health, medical and global domains based on the literature and our earlier studies. We then carried out univariable logistic regression analyses to identify the variables most strongly associated with developing a new need for long‐term care within each domain. Variables showing the strongest association were further analyzed in a forward stepwise multivariable logistic regression model to determine the significant predictors.ResultsThe multivariable model identified age, sex, doing heavy housework, walking 200 m, carrying out calculation, appetite status, frequency of hospitalizations during the past 12 months, living arrangement and weight loss as significant (P < 0.05) predictors.ConclusionsThe present study identified nine characteristics that predict the subsequent 4‐year new need for long‐term care of ≥70‐year‐old Taiwanese adults. Age, sex and functional status are the most powerful predictors. The results are useful for identifying older individuals at risk of developing a new need for long‐term care within the next 4 years, enabling implementation of preventive strategies or timely care planning. Geriatr Gerontol Int 2019; 19: 641–646.
Effect of watching professional baseball at a stadium on health‐related outcomes among Japanese older adults: A randomized controlled trial
Authors: Kawakami Ryoko , Sawada Susumu S , Ito Tomoko , Gando Yuko , Fukushi Tomohiro , Yoshino Atsushi , Kurita Satoshi , Oka Koichiro , Sakamoto Shizuo , Higuchi Mitsuru 
Published: May 2019

AimWatching sports at stadiums can have a favorable impact on health‐related outcomes in older adults. We examined the effect of watching professional baseball at a ballpark on older adults’ health‐related outcomes.MethodsA total fo 58 participants aged 65–85 years were randomized into a spectator group (n = 29) and waiting‐list group (n = 29). During the 2‐month intervention, there were 21 games. The spectator group watched games at the ballpark, and the waiting‐list group maintained their daily routines. The health‐related outcomes were executive and cognitive functions, health‐related quality of life, depression symptoms, subjective happiness and physical activity.ResultsThe median days watching baseball games in the spectator group was 6 days (interquartile range 4–10 days). Executive function using the reverse Stroop interference rate showed a non‐significant trend of improvement in the spectator group compared with the waiting‐list group (P = 0.063). The spectator group showed a significant reduction in depressive symptoms compared with the waiting‐list group (P = 0.016).ConclusionsRegularly watching professional baseball at a ballpark reduced older adults’ depression symptoms. Geriatr Gerontol Int 2019; 19: 717–722.
Essential oil nanoemulsions: antibacterial activity in contaminated fruit juices
Authors: Franklyne Jonathan Sampath , Iyer Swati , Ebenazer Andrew , Mukherjee Amitava , Chandrasekaran Natarajan 
Published: May 2019

SummaryMany human acid tolerant bacterial and fungal pathogens can be transmitted through the consumption of the contaminated fruit juices. We aim to formulate essential oil nanoemulsions (basil, black seed, turmeric, clove & cinnamon), determine their ability to clear contamination by food borne bacterial pathogens from fruit juices. The antibacterial activity of the optimised formulations was tested in the fruit juices against bacterial pathogens causing gastrointestinal tract infections. The minimum bactericidal concentration (MBC) of clove emulsions ranged from 15.6 to 25 μL mL−1. Cinnamon oil emulsion had an MBC ranging between 15 and 31 μL mL−1. At MBC, cinnamon oil emulsions caused a 6log10 decrease in viable counts by 8 h and maintained the sterility of fruit juices for 7 days at ambient temperature. Thus, clove and cinnamon microemulsions can be used as juice additives to control food borne bacterial pathogens and maintain the bacterial sterility of fruit juices.
Effect of ethanol on properties of extrudates enriched with high‐fibre by‐products
Authors: Tomaszewska‐Ciosk Ewa , Zdybel Ewa , Lech Krzysztof , Nemś Agnieszka 
Published: May 2019

SummaryIn this study, we produced snacks based on mixtures of corn grits enriched with ethyl alcohol and high‐fibr by‐products like potato pulp, as well as flaxseed, rosehip and apple pomace. The prepared mixtures were subjected to the extrusion at the following process parameters: temperature of section I – 130 °C, temperature of section II – 150 °C, temperature of section III – 170 °C and screw speed – 200 r.p.m. The presence of ethanol in the extruded mixture significantly improved mechanical properties and increased colour lightness of snacks. The highest scores were given in sensory analysis to control snacks, whereas among the enriched snacks – to these with apple pomace. The most negative effect on snacks assessment was attributed to the addition of flaxseed and rosehip pomace. Ethanol addition had a very beneficial effect on scores given during sensory analysis to colour, texture and structure attributes of the snacks.
Comparison of phytochemical profiles, cellular antioxidant and anti‐proliferative activities in five varieties of wampee (Clausena lansium) fruits
Authors: Ye Yutong , Chang Xiaoxiao , Brennan Margaret Anne , Brennan Charles Stephen , Guo Xinbo 
Published: May 2019

SummaryWampee (Clausena lansium) fruit is a seasonal food containing high levels of bioactive phytochemicals which may be useful for health benefits. This study compared the phytochemical composition, total and cellular antioxidant activities (CAA) as well as anti‐proliferative activities of five different varieties of wampee fruits. The results showed that six phytochemical compounds (vanillic acid, ferulic acid, rutin, syringin, catechin and hesperetin) were found in wampee fruits. Total antioxidant activities varied dramatically in these five varieties when measured with oxygen radical absorbance capacity assay and peroxyl radical scavenging capacity assay. The results also showed that wampee fruit extracts varied enormously in their CAA and exhibited significant anti‐proliferative activities against HepG2 human liver cancer cells. These results suggest the potential of wampee fruits as functional foods and industrial application of wampee fruit in the future.
Electronic devices and myopic refraction among children aged 6‐14 years in urban areas of Tianjin, China
Authors: Liu Shengxin , Ye Sheng , Xi Wei , Zhang Xin 
Published: May 2019

AbstractPurposeTo assess associations between different types of electronic devices, myopic refraction and ocular biometric parameters in children aged 6–14 years in urban areas of Tianjin, China.MethodsA school‐based, cross‐sectional study was performed on 566 children (302 boys and 264 girls). The children underwent a comprehensive eye examination, including cycloplegic autorefraction and ocular biometry. The children's parents completed a detailed questionnaire that included each child's demographics, the use of electronic devices and other related risk factors.ResultsMyopia was not associated with time spent using various electronic devices. However, the mean spherical equivalent refraction (SER) decreased by 0.28 D (p = 0.042) and 0.33 D (p = 0.018) for each 1‐h increase in the time spent using smart phones and computers, respectively. In the multiple linear regression analyses of factors associated with theSER, the standardised coefficient B for time spent reading and writing was approximately four to five times larger than the standardised coefficient for time spent using smart phones or computers. Time spent using tablets and watching television was not significantly associated with theSER. A longer axial length (AL) was associated with more time spent using smart phones (B = 0.23,p = 0.006) and computers (B = 0.26,p = 0.002) but not using tablets (p = 0.45) and watching television (p = 0.45). No significant association was found between other ocular biometric parameters and time spent using various electronic devices.ConclusionsOn average, a more myopicSERand longerALwere both associated with more time spent using smart phones and computers, but not with time spent using tablets and watching television. The magnitude of the association betweenSERand time spent reading and writing was a substantially larger than that for smart phone or computer use. Different types of electronic devices had differing levels of association with myopic refraction.
P69 Pharmacokinetics of a continuous infusion of piperacillin/tazobactam to children using an elastomeric pump (POPPET Study): pilot data from double lumen central lines
Authors: Moss J , Price V , Paulus S , Ramos-Martin V , Melaine A , Evans E , Newland P , Hope W , Hawcutt D , Pizer B 
Published: May 2019

BackgroundPiperacillin/Tazobactam is the first-line antibiotic for the treatment of febrile neutropenia in the UK. There is increasing interest in administration by continuous infusion in adult studies, but paediatric data is lacking. A continuous infusion, if given via an elastomeric pump could also facilitate earlier discharge from hospital.MethodsChildren with an oncology/haematology diagnosis admitted to Alder Hey Children’s Hospital with febrile neutropenia, normally treated with Piperacillin/Tazobactam via elastomeric device were considered eligible for the study. Patients received 24–36 hours of intermittent dosing before continuous dosing commenced via elastomeric pump. We analysed the data from 5 patients with double lumen central lines as a pilot phase to determine if expanded recruitment to include patients with single lumen lines was possible.ResultsFive patients were recruited, four of which had the continuous infusion. The mean Cmax following intermittent dosing of piperacillin and tazobactam from the lumen used for drug administration were 189.7 mg/L, 95% CI [71.7 - 307.9] and 18.5 mg/L, 95% CI [10.7, 26.3] respectively. The mean Cmax following intermittent dosing for the ‘empty’ lumen were 160.5 mg/L, 95% CI [121.6 - 199.4] for piperacillin and 13.7 mg/L, 95% CI [11.2 - 16.3] for tazobactam. The largest difference seen was on patient 002 with a concentration of piperacillin almost double that seen in the ‘empty’ lumen (429 mg/L vs 233 mg/L).ConclusionThe lumen used for drug administration has enough residual drug to influence the results, so expanding recruitment to include single lumen lines is not going to be undertaken. The study has been amended to recognise this, and recruitment will continue with double lumen central lines only.Disclosure(s)Nothing to disclose
O11 Characterising the pharmacokinetics of phenobarbitone in neonates to facilitate future individualised dosing
Authors: Williams A , Donovan T , Charles B , Staatz C 
Published: May 2019

BackgroundPhenobarbitone is commonly used as a first-line drug in the treatment of neonatal seizures. Previous studies, with small subject numbers, have identified covariates that may influence the pharmacokinetics of phenobarbitone but results have been inconsistent. In particular, oral bioavailability is poorly described with doses reported as being identical for intravenous and oral administration, however, 2 recent studies have reported oral bioavailability of 49% and 59% respectively.1,2MethodsA population pharmacokinetic model was built based on routine therapeutic drug monitoring data from 112 infants at the Royal Brisbane and Women’s Hospital Neonatal Intensive Care Unit. Population modelling was performed using NONMEM 7.3 and PsN 4.7 with assistance from R studio and the packages Xpose and VPC. Body weight with allometric scaling on Clearance (CL) and Volume of Distribution (V) were included a priori in the structural model. Covariates tested included age (post-menstrual, gestational and post-natal), Apgar scores, concomitant phenytoin treatment, infection and method of nutrition.ResultsA one-compartment model provided an adequate fit to the data. Typical clearance increased with patient post-natal age (PNA) and was best modelled using the equation CL = 5.1 *WT0.75 * (PNA/6.25)0.43 (mL/h) were weight is in kg, PNA in days and 6.25 is the median post-natal age. Volume of distribution (V) was best modelled using the equation V = 799 * WT1.0 (mL). Oral bioavailability (F) was 85%. Between-subject variability was 25% and 30% respectively for CL and V.ConclusionThis study describes the largest population pharmacokinetic model of phenobarbitone developed to date with estimates of CL and V similar to previously published models. Estimated F is higher than previously reported but still lower than the implied F of 100% in most recommended dosing regimens. The model could be used to assist with future individualisation of dosing in this cohort.ReferencesMarsot A, et al. Pharmacokinetics and absolute bioavailability of phenobarbital in neonates and young infants, a population pharmacokinetic modelling approach. Fundam Clin Pharmacol 2014;28(4):465–71.Voller S, et al. Model-based clinical dose optimization for phenobarbital in neonates: An illustration of the importance of data sharing and external validation. Eur J Pharm Sci 2017;109s:S90–S97.Disclosure(s)Nothing to disclose
P75 Relation between polymorphism of folic acid cycle genes and effectiveness of methotrexate in children with juvenile idiopathic arthritis
Authors: Panko N 
Published: May 2019

BackgroundMethotrexate (MTX) is the basic treatment of patient with Juvenile Idiopathic Arthritis (JIA), but effectiveness of this therapy is different. We aimed to study effectiveness of MTX in children with JIA with different genotypes of folic acid cycle genes.MethodsThe study included 8 patients with JIA. For determination of MTX effectiveness the American College of Rheumatology pediatric criteria (ACR-pedi) was used. Patients were divided into 2 groups according the effectiveness of MTX treatment. Group I included 4 patients, who were non-responders because ACR-pedi was less than 10%. Second group contained 4 patients, who had ACR-pedi more than 10%. The megerment of genotypes of genes of folate cycle, such as 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR), 5,10methylenetetrahydrofolate reductase C677T and A1298C variants (MTHFR-677 and MTHFR129) by polymerase chain reaction (PCR) was performed for all patients.ResultsIn II group effectiveness of therapy according ACR-pedi was from 30% to 70% in 75% of children and more then 70% - in 25% of patients. In general, MTR gene indicated AA-genotype in 50% of patients, AG and GG-genotypes - in 25%; MTRR gene was performed with AA-genotype in 25%, AC-genotype in 12.5% and CC-genotype in 62.5%. MTHFR1298 gene was presented in 50% of patients with AA-alleles, in 25% - with AC and CC-genotypes. 50% of children had CC-genotype of MTHFR677 gene and other 50% - AC-genotype of MTHFR677 gene. CC-genotype of MTHFR1298 gene more frequently was determined in II group (p< 0.01). In group of non-responders AA-genotype of MTR gene was found more frequent in comparison with patients from group II (p< 0.01).ConclusionResponse to standard therapy in patients with JIA depends on time of prescription of MTX and genotype of MTHFR1298 and MTR genes.Disclosure(s)Nothing to disclose
P79 Pharmacokinetics of sufentanil in critically ill neonates
Authors: Pokorná P , Šíma M , Koch B , Tibboel D , Slana&rcaron; O 
Published: May 2019

BackgroundSufentanil is a potent synthetic opioid increasingly used as an analgesic drug for pain treatment in critically ill neonates. Clinical studies concerning the pharmacokinetics (PK) of sufentanil administered as a bolus or continuous infusion in neonates are sparse and a population model has been developed for critically ill children beyond the newborn period. The aim of our study was to determine the PK of sufentanil in critically ill neonates treated with continuous sufentanil infusion for pain management (prophylactic and therapeutic use).MethodsEight term neonates (birth weight 2.60–4.30 kg; postnatal age 2–96 h) were treated with sufentanil (initial bolus 0.1–0.5 µg/kg i.v. administered for 5 minutes followed by continuous infusion 0.1–0.5 µg/kg per hour i.v.). Sufentanil plasma concentrations were determined using a UPLC-MS/MS assay. Totally 159 sufentanil concentrations were measured (8–27 measurements per patient). Individual sufentanil PK parameters were calculated in a two-compartmental PK model with first-order elimination kinetics based on individual demographic and clinical data and observed sufentanil plasma levels using MWPharm++ software (MediWare, Prague, Czech Republic). The sufentanil population PK model was individualized to maximize fitting of the simulated PK profile curve with observed concentration points. The fitting was performed using Bayesian method.ResultsMedian (IQR) sufentanil central and total volume of distribution, clearance, and distribution and elimination half-life were 4.7 (4.2–5.2) L/kg and 11.8 (9.9–14.2) L/kg, 0.552 (0.415- 0.671) L/h/kg, and 0.0264 (0.0260–0.0264) h and 15.7 (13.4–19.2) h, respectively.ConclusionWe observed similar sufentanil PK parameters (preliminary results) as described previously in literature. However, further studies with more patients are needed.FundingThis study is supported by a Charles University project Progres Q25, SVV 260373 and a project MH CZ-DRO - VFN64165, and by an unrestricted research grant of the Intensive Care of the ErasmusMC-Sophia Children’s Hospital.Disclosure(s)Nothing to disclose
P80 Objective pharmacodynamic evaluation of doxapram in preterm infants
Authors: Poppe JA , van Weteringen W , Völler S , Goos TG , Reiss IKM , Simons SHP 
Published: May 2019

BackgroundPharmacodynamic evaluation is challenging in neonatal clinical care, and often based on subjective human interpretation of clinical signs and the available ‘snapshot’ of physiological parameters. High frequency data (≥ 1Hz) of bedside patient monitors provide the opportunity of continuous and objective drug evaluation.1 This study investigates the predictive value of continuously available vital and ventilatory parameters to evaluate doxapram therapy. Doxapram is a respiratory stimulant to avoid mechanical ventilation and adverse outcomes of hypoxemia in preterm infants.2MethodsPreterm infants admitted to a level III NICU centre who received doxapram therapy were eligible for inclusion. Stored vital and ventilatory parameters were retrospectively analysed. Multivariate analysis was performed to identify variables that influenced therapy failure (intubation or death) or success. Variables with a p value < 0.1 in univariate analysis were included in the multivariate analysis. Additionally, the ΔSpO2/FiO2-ratio was calculated by subtracting the median SpO2/FiO2-ratio 1 day after therapy from the median SpO2/FiO2-ratio 1 day before therapy.ResultsThe first episode of doxapram treatment was analysed in a total of 61 preterm infants with a median postnatal age at therapy start (PNA) of 3.0 weeks (IQR; 2.0–3.6). The success rate of doxapram therapy was 57%. Out of all parameters, the SpO2/FiO2-ratio showed to be the most indicative for therapy outcome. The predictive model included the ΔSpO2/FiO2-ratio, the PNA, the administration of a loading dose at start, and intubation within 24 hours before the start of doxapram (area under the curve of 0.828). The ΔSpO2/FiO2-ratio was inversely associated with therapy outcome (OR 0.26, CI 95% 0.07–0.83; p = 0.03).ConclusionThe ΔSpO2/FiO2-ratio between 1 day before and 1 day after start of the therapy is predictive of failure or success of doxapram therapy. The use of physiological data shows potential in the pharmacodynamic evaluation of doxapram therapy.ReferencesFlint R, Weteringen WV, Voller S, Poppe JA, Koch BC, Groot R, et al. Big data analyses for continuous evaluation of pharmacotherapy: A proof of principle with doxapram in preterm infants. Curr Pharm Des. 2017.Poets CF, Roberts RS, Schmidt B, Whyte RK, Asztalos EV, Bader D, et al. Association Between Intermittent Hypoxemia or Bradycardia and Late Death or Disability in Extremely Preterm Infants. JAMA. 2015;314(6):595–603.Disclosure(s)Nothing to disclose