bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rare case of hepatocellular carcinoma and colorectal liver metastasis
Authors: Alwabel Wed K , Aljesh Saud M , Alsamaani Ibrahim S , Alrasheed Ayman S , Alzahrani Nayef A 
Published: November 2024

Abstract
Hepatocellular carcinoma is the third leading cause of cancer deaths worldwide, with a 5-year survival rate of 20.3%, while colorectal cancer is a major cause of morbidity and mortality worldwide, being the third most common cancer in men and the second in women. In addition, multiple primary tumors, involving cancers at different sites and histologies, occur in 2.4% to 17% of cases. We report a case of a 74-year-old man with colon cancer presented at the Emergency Department with asymptomatic anemia post chemotherapy and surgical intervention two years ago. He reported experiencing paleness, dizziness, exertional dyspnea, and fatiguability for the past month. Therefore, chest computed tomography was performed to rule out pulmonary embolism; however, the image revealed an incidental finding of two hepatic lesions in segment II. After further investigations, the decision was to perform hepatic segmentectomy. Postoperative pathology revealed residual Hepatocellular carcinoma and metastatic colonic-type adenocarcinoma with mucinous differentiation.
Stanford A aortic dissection 40 years after aortic valve replacement with a Starr–Edwards caged-ball prosthesis: a case report
Authors: Tokic Tomislav , Hasnas Lea , Mikulic Lovro , Markovic Pavel , Gustek Stella , Kucina Anamarija , Jurca Ivana , Sipus Dubravka , Mihaljevic Martina Zrno , Gasparovic Hrvoje , Burcar Ivan 
Published: November 2024

Abstract
Stanford A aortic dissection is one of the most devastating acute medical conditions due to its high morbidity and mortality. We describe a 77-year-old male patient with a medical history of surgical aortic valve replacement with a still functioning Starr–Edwards caged-ball valve 40 years prior. The patient was promptly diagnosed with an ascending aortic aneurysm and dissection, and an emergency Bentall procedure in deep hypothermic circulatory arrest was performed. This is, to the best of our knowledge, the first Stanford A dissection case described in the literature in a patient with Starr–Edwards valve, and the longest still functioning caged-ball valve to have been replaced with the Bentall procedure. We also discuss the caged-ball valve’s unfavorable hemodynamics as a potential predisposing factor of the dissection, as well as the patient’s supposed initial bicuspid aortic valve disease which could also predispose to aortic aneurysm formation and dissection.
Idiopathic pneumoperitoneum after gynecological surgery: a report of two clinical cases
Authors: Boligo Sofia , Santos Cláudia , Contente Helena 
Published: November 2024

Abstract
Pneumoperitoneum, characterized by the presence of air in the peritoneal cavity, is usually associated with severe clinical conditions, such as perforations of hollow viscera, often requiring urgent surgical intervention. However, in rare cases, pneumoperitoneum occurs without an identifiable cause, thus classified as idiopathic pneumoperitoneum. We present two clinical cases of women who developed pneumoperitoneum after extensive gynecological surgeries. In the first case, a 63-year-old woman underwent elective hysterectomy and bilateral adnexectomy due to a large adnexal mass. In the second case, a 55-year-old woman had a similar surgical history. Both patients were treated conservatively, with a positive outcome. Idiopathic pneumoperitoneum is a diagnostic and therapeutic challenge, especially in the postoperative context. The cases presented underscore the importance of rigorous diagnostic evaluation and a cautious therapeutic approach, suggesting that idiopathic pneumoperitoneum may represent a benign and self-limiting phenomenon rather than a surgical emergency.
European Banks and Substantial EU Financial Law Frameworks
Authors: Lo Schiavo Gianni 
Published: November 2024

Abstract
This chapter evaluates other EU financial frameworks that have an impact on the conduct of the business of credit institutions in Europe. Although the prudential framework is undoubtedly the most complex and relevant regulatory framework for banks, the key to ensuring the good functioning of banks and appropriate risk assessments is that credit institutions need to comply with a number of provisions deriving from other areas of EU financial law. Among others, the chapter considers the financial conglomerate framework for banking groups (the FICOD regime); the EU rules on markets in financial instruments and activities; rules on market abuse; the anti-money laundering/counterterrorist financing framework; the deposit insurance rules; payments regulation; and retail financial services rules. Other frameworks not relating to substantive rules applicable to banks but having an impact on financial markets broadly are not examined in this chapter. Among others, these are EU rules on prospectuses, covered bonds, transparency of consolidated accounts, credit rating agencies, and trading venues.
EU Banking Resolution, Insolvency Framework, and Public Interventions
Authors: Lo Schiavo Gianni 
Published: November 2024

Abstract
This chapter investigates the complex legal framework of EU banking resolution, insolvency, and public interventions under EU law. It begins with a brief overview of banking resolution and insolvency theories. The chapter then looks at the EU framework for banking resolution in the Bank Recovery and Resolution Directive by examining the preparatory aspects for resolution, the core resolution tools, and the powers of resolution authorities. It then moves to the rules of the Single Resolution Mechanism as the supranational framework for resolution where the Single Resolution Board is the EU agency in charge of orderly resolutions in Europe together with the national resolution authorities, and the Single Resolution Fund is the fund established to ensure sufficient financial resources in case private sources are insufficient. A section looks at the application or non-application of the resolution framework in case studies. Finally, the chapter considers state interventions under the EU state aid framework and discusses the (lack of) an orderly EU insolvency framework for banks.
Added prognostic value of DCE blood volume imaging in patients with suspected recurrent or residual glioblastoma—A hybrid [18F]FET PET/MRI study
Authors: Henriksen Otto Mølby , Muhic Aida , Lundemann Michael Juncker , Larsson Henrik Bo Wiberg , Lindberg Ulrich , Andersen Thomas Lund , Hasselbalch Benedikte , Møller Søren , Marner Lisbeth , Madsen Karine , Larsen Vibeke Andrée , Poulsen Hans Skovgaard , Hansen Adam Espe , Law Ian 
Published: November 2024

Abstract

Background
Magnetic resonance imaging (MRI) cerebral blood volume (CBV) measurements improve the diagnosis of recurrent gliomas. The study investigated the prognostic value of dynamic contrast-enhanced (DCE) CBV imaging in treated IDH wildtype glioblastoma when added to MRI or amino acid positron emission tomography (PET).

Methods
Hybrid [18F]FET PET/MRI with 2CXM (2-compartment exchange model) DCE from 86 adult patients with suspected recurrent or residual glioblastoma were retrospectively analyzed. High CBV tumor volume (VOLCBV), and contrast-enhancing (VOLCE) and [18F]FET active tumor (VOLFET) volumes were delineated. Absolute and fractional high CBV subvolumes within VOLCE and VOLFET were determined. Associations with overall survival (OS) were assessed by Cox analysis.

Results
Adjusted for methyltransferase gene status and steroid use all total tumor volumes were individually associated with shorter OS. Adding VOLCBV to VOLCE or VOLFET only the effect of VOLCBV was prognostic of OS (hazard ratio [HR] 1.327, P = .042 and 1.352, P = .011, respectively). High CBV subvolumes within both VOLCE and VOLFET were associated with shorter survival (HR 1.448, P = .042 and 1.416, P = .011, respectively), and the low CBV subvolumes with longer survival (HR 0.504, P = .002 and .365, P = .001, respectively). The fraction of VOLCE and VOLFET with high CBV was a strong predictor of OS with shorter median OS in upper versus lower tertiles (8.3 vs 14.5 months and 7.1 vs 15.6 months, respectively, both P &lt; .001).

Conclusions
The high CBV tumor volume was a strong prognosticator of survival and allowed for the separation of high- and low-risk subvolumes underlining the heterogeneous physiological environment represented in the contrast-enhancing or metabolically active tumor volumes of treated glioblastoma.
Awakening of Maunaloa Linked to Melt Shared from Kīlauea’s Mantle Source
Authors: Pietruszka Aaron J , Heaton Daniel E , Marske Jared P , Norman Marc D , Robbins Mahinaokalani G , Mershon Reed B , Lynn Kendra J , Downs Drew T , Steiner Arron R , Rhodes J Michael , Garcia Michael O 
Published: November 2024

Abstract
Maunaloa—the largest active volcano on Earth—erupted in 2022 after its longest known repose period (~38 years) and two decades of volcanic unrest. This eruptive hiatus at Maunaloa encompasses most of the ~35-year-long Puʻuʻōʻō eruption of neighboring Kīlauea, which ended in 2018 with a collapse of the summit caldera and an unusually voluminous (~1 km3) rift eruption. A long-term pattern of such anticorrelated eruptive behavior suggests that a magmatic connection exists between these volcanoes within the asthenospheric mantle source and melting region, the lithospheric mantle, and/or the volcanic edifice. The exact nature of this connection is enigmatic. In the past, the distinct compositions of lavas from Kīlauea and Maunaloa were thought to require completely separate magma pathways from the mantle source of each volcano to the surface. Here, we use a nearly 200-yr record of lava chemistry from both volcanoes to demonstrate that melt from a shared mantle source within the Hawaiian plume may be transported alternately to Kīlauea or Maunaloa on a timescale of decades. This process led to a correlated temporal variation in 206Pb/204Pb and 87Sr/86Sr at these volcanoes since the early 19th century with each becoming more active when it received melt from the shared source. Ratios of highly over moderately incompatible trace elements (e.g. Nb/Y) at Kīlauea reached a minimum from ~2000 to 2010, which coincides with an increase in seismicity and inflation at the summit of Maunaloa. Thereafter, a reversal in Nb/Y at Kīlauea signals a decline in the degree of mantle partial melting at this volcano and suggests that melt from the shared source is now being diverted from Kīlauea to Maunaloa for the first time since the early to mid-20th century. These observations link a mantle-related shift in melt generation and transport at Kīlauea to the awakening of Maunaloa in 2002 and its eruption in 2022. Monitoring of lava chemistry is a potential tool that may be used to forecast the behavior (e.g. eruption rate and frequency) of these adjacent volcanoes on a timescale of decades. A future increase in eruptive activity at Maunaloa is likely if the temporal increase in Nb/Y continues at Kīlauea.
The wheat CC-NBS-LRR protein TaRGA3 confers resistance to stripe rust by suppressing ascorbate peroxidase 6 activity
Authors: Fang Nannan , Jia Conghui , Chen Ruolin , An Jiarui , Kang Zhensheng , Liu Jie 
Published: November 2024

Abstract
Nucleotide-binding leucine-rich repeat (NLR) proteins are intracellular immune receptors that activate innate immune responses upon sensing pathogen attack. However, the molecular mechanisms by which NLR proteins initiate downstream signal transduction pathways to counteract pathogen invasion remain poorly understood. In this study, we identified the wheat (Triticum aestivum) NLR protein Resistance Gene Analogs3 (TaRGA3), which was significantly upregulated during Puccinia striiformis f. sp. tritici (Pst) infection. TaRGA3 and its coiled-coil (CC) domain, localized to the cytoplasm and nucleus, can induce cell death in Nicotiana benthamiana. Virus-induced gene silencing and overexpression suggested that TaRGA3 contributed to wheat resistance to stripe rust by facilitating reactive oxygen species (ROS) accumulation. Yeast 2-hybrid, luciferase complementation imaging, and co-immunoprecipitation assays revealed that TaRGA3 interacted with wheat protein Ascorbate Peroxidase 6 (TaAPX6). Further analysis showed that TaAPX6 specifically targeted the CC domain of TaRGA3. The TaRGA3–TaAPX6 interplay led to reduced enzyme activity of TaAPX6. Notably, TaAPX6 negatively regulated wheat resistance to Pst by removing excessive ROS accompanying Pst-induced hypersensitive responses. Our findings reveal that TaRGA3 responding to Pst infection confers enhanced wheat resistance to stripe rust, possibly by suppressing TaAPX6-modulated ROS scavenging, and demonstrate that TaRGA3 can be used to engineer stripe rust resistance in wheat.
Women are awarded more team than solo grants and lead more gender-balanced teams than men
Authors: Kingsley Isabelle , Slavich Eve , Harvey-Smith Lisa , Johnston Emma L , Williams Lisa A 
Published: November 2024

Abstract
We modelled patterns of collaboration, team gender composition, and funding amounts across awarded Australian government-funded competitive team research grants from 2000 to 2020. The percentage of grants awarded to women at mid- and senior-career levels was higher for team grants than sole investigator grants compared to men at those levels. Teams led by women tended to have a greater percentage of women coinvestigators than teams led by men, but this was below gender parity regardless of team leader gender. Funding amounts per grant did not differ by the principal investigator’s gender and reached parity in 2020 across teams with both high and low representation of women. Since teams tend to be more gender-balanced when led by women, women’s grant leadership may be an important mechanism for shifting overall representation of women in research. We offer public policy measures to address gender inequities in the research sector.
Human umbilical cord mesenchymal stem cells small extracellular vesicles-derived miR-370-3p inhibits cervical precancerous lesions by targeting DHCR24
Authors: Li Weizhao , Zhang Chi , Gao Tianshun , Sun Yazhou , Yang Huan , Liu Lixiang , Shi Ming , Ding Lu , Zhang Changlin , Deng David Y B , Li Tian 
Published: November 2024

Abstract

Background
Cervical cancer is often caused by persistent high-risk human papillomavirus (HPV) infection, causing precancerous lesions. Human umbilical cord mesenchymal stem cells-derived small extracellular vesicles (hucMSC-sEV) exhibit diverse effects on tumors. This study investigates hucMSC-sEV, the impact and mechanisms on HPV-positive cervical precancerous lesion cells to provide new treatment insights.

Materials and Methods
We previously obtained hucMSC and hucMSC-sEV. In vitro experiments evaluated hucMSC-sEV effects on the proliferation and migration of S12 cells (derived from cervical precancerous lesions). Bioinformatics identified key microRNA components, and their impact on S12 cell proliferation and migration was investigated. The target gene of the microRNA component was predicted and confirmed via bioinformatics and dual-luciferase reporter assays. Lentiviral systems overexpressed target gene in S12 cells to examine the effects on microRNA impacts. SH-42 inhibitor was used to investigate target gene treatment potential. Immunohistochemistry assessed target gene expression in cervical precancerous lesions tissue.

Results
hucMSC-sEV significantly inhibited S12 cell proliferation and migration. Bioinformatics identified miR-370-3p as an effective cargo, which also suppressed S12 cell proliferation and migration. miR-370-3p was confirmed targeting DHCR24 (24-Dehydrocholesterol Reductase). DHCR24 overexpression reversed miR-370-3p’s inhibitory effects, while SH-42 counteracted DHCR24 overexpression’s promoting effects. Clinical specimen analysis supported these findings, demonstrating a positive correlation between DHCR24 protein expression and cervical precancerous lesions’ progression.

Conclusions
hucMSC-sEV inhibits S12 cell proliferation and migration, mediated by miR-370-3p targeting DHCR24 to regulate cellular cholesterol content. DHCR24 inhibition reduces the cholesterol level and cell functions, suggesting its potential as a therapeutic target in cervical precancerous lesions.
Tunnel sign in patients with melioidosis: a case series from South India
Authors: Gupta Nitin , Malla Sundeep , Kumar Tirlangi Praveen , Singh Sonali , Varma Muralidhar , Mukhopadhyay Chiranjay 
Published: November 2024

Abstract

Introduction
The tunnel sign (linear contrast enhancement along the corticospinal tract) can aid in the early diagnosis of neuromelioidosis, a potentially fatal condition requiring urgent diagnosis.

Methodology
We retrospectively analyzed the hospital data of all patients with culture-confirmed melioidosis between 2018 and 2023 in a tertiary care hospital in South India. MRI scans of patients with neuromelioidosis were reviewed for the presence of the tunnel sign.

Results
Of the 177 patients with melioidosis, 21 had possible neurological involvement. Seven had confirmed neuromelioidosis. Of the six patients with neuromelioidosis, where an MRI scan was available, a tunnel sign was noted in four.

Conclusion
We report this study to create awareness amongst physicians to look for this sign in patients with suspected neuromelioidosis.
Integrative analysis of non12‐hydroxylated bile acid revealed the suppressed molecular map of alternative pathway in nonalcoholic steatohepatitis mice
Authors: Feng Yanruyu , Liu Chang‐Hai , Yang Jingtao , Zhang He , Li Lian , Yang Qian , Gan Wei , Yang Zi , Gong Puyang , Fu Chunmei , Qian Guangsheng , Li Dapeng 
Published: November 2024

AbstractBile acids (BAs) are significantly altered in the liver and serum of patients with nonalcoholic steatohepatitis (NASH). However, the underlying mechanisms of these changes, particularly BA alternative pathways (BAP) responsible for non12‐OH BAs, remain unclear. RNA‐seq data were initially analyzed to reveal the changes of gene expression in NASH patients. Targeted metabolomics were conducted on plasma from NASH mice induced by high‐fat or western diet with CCl4 for 10–24 weeks. Liver tissues were examined using proteomics, RT‐qPCR, and western blotting. An integrated approach was then employed to analyze protein interactions and network correlations. Analysis of RNA‐seq data revealed the inhibition of CYP7B1 in NASH patients, indicating the dysregulation of BAP. In NASH mouse models, dysregulation of BA circulation was observed by increased plasma total BA (TBA) levels and decreased liver TBA, with liver swelling and histopathological changes. Targeted metabolomics revealed suppressed levels of non12‐OH BAs, which inversely correlated with increased liver injury markers. The reduced mRNA and protein expression of Fxr and upregulation of Lxr signaling in livers suggested the suppressed BAP was modulated by Fxr‐Lxr signaling. Moreover, BAP interactions predominantly implicated multiple metabolism disruptions, involving 7 hub proteins (Hk1, Acadsb, Pklr, Insr, Ldlr, Cyp27a1, and Cyp7b1), offering promising therapeutic targets for NASH. We presented the metabolic and proteomic map of BAP and its regulatory network in NASH progression. Therapeutic targeting of BAP or its co‐regulatory proteins holds promise for NASH treatment and metabolic syndrome management.
CXCL13 promote angiogenesis by recruiting M2 macrophages and endothelial progenitor cells in beige adipose grafts
Authors: Zhang Xining , Chen Xinyao , Li Jiapeng , Liu Ying , Luo Sai 
Published: November 2024

AbstractFat grafting is an emerging clinical technique to address soft tissue deficiencies. This study investigates whether the secretory function of beige adipose tissue(BeigeAT) grafts is involved in promoting soft tissue regeneration in fat grafting. In this study, mice were randomly divided into white adipose tissue (WAT) and BeigeAT groups. Each type of adipose tissue (0.3 mL) was transplanted into the respective groups, and samples were harvested at 2, 4, and 12 week. Subsequently, mice were further divided into three groups, BeigeAT group, BeigeAT with CXCL13 treatment group, and BeigeAT with TAK‐779 treatment group, to investigate the role of CXCL13 in BeigeAT transplants. Graft retention rate, vascularization, and fibrosis levels were compared among the groups. Compared to WAT transplants, BeigeAT transplants exhibited moderate inflammation, enhanced revascularization, reduced fibrosis, and increased infiltration of M2 macrophages and endothelial progenitor cells in the early stages following fat grafting. CXCL13 expression was significantly higher in BeigeAT transplants at 2, 4, and 12 week post‐grafting. Additionally, modulation of CXCL13 expression affected the infiltration of M2 macrophages and endothelial progenitor cells. However, BeigeAT transplants exhibited superior retention rates compared to BeigeAT CXCL13 groups and BeigeAT TAK‐779 groups after 12 weeks of fat grafting. BeigeAT transplants achieve improved retention rates through CXCL13‐induced infiltration of M2 macrophages and endothelial progenitor cells.
Static Versus Expandable Cages in Minimally Invasive Lateral Lumbar Interbody Fusion
Authors: Beyer Ryan S. , Shooshani Tara , Batista Bianca , Fraipont Genevieve M. , Pooladzandi Omead , Brown Nolan J. , Pennington Zach , Pham Martin H. 
Published: November 2024

Study Design:
A meta-analysis approach to a systematic review.

Objective:
Perform a systematic review to identify all reports directly comparing outcomes of lateral lumbar interbody fusion (LLIF) using static versus expandable interbody cages. Specifically focusing on periprocedural complications, intraoperative morbidity, and fusion outcomes.

Summary of Background Data:
Minimally invasive surgical techniques, particularly LLIF, have gained popularity for their potential to reduce muscle and soft tissue dissection, leading to faster postoperative recovery. LLIF has been associated with fewer complications compared with open posterior approaches. The introduction of expandable lumbar interbody devices aims to further reduce surgical difficulty and potential complications. However, concerns include a small graft window due to the expansion mechanism and higher costs.

Methods:
The Web of Science, Scopus, and PubMed databases were systematically queried in accordance with PRISMA guidelines to identify articles comparing outcomes following LLIF using static and expandable interbodies. The Newcastle-Ottawa Scale (NOS) was employed to assess the risk of bias (ROB) in the selected studies. Extracted data underwent effect-size meta-analysis with the PyMARE library, using P<0.05 to define statistical significance.

Results:
Of the 77 identified articles, 4 studies comprising 283 patients (mean age: 67.1 y, 55.8% female) met the inclusion and exclusion criteria. A total of 150 patients (53%) were treated with static interbodies compared with 133 (47%) receiving expandable interbodies. The groups did not differ significantly with respect to operative time (P=0.59), blood loss (P=0.89), length of stay (P=0.78), subsidence (P=0.49), 24-month mean disc height (P=0.11), 24-month mean ODI (P=0.58), or 24-month mean visual analog scale (VAS) back pain (P=0.81). The expandable group saw a trend toward improved fusion rates (97% vs. 92%, P=0.06).

Conclusions:
The present meta-analysis suggests the use of expandable (vs. static) interbodies in LLIF surgery may result in similar surgical morbidity, subsidence, and decompression. Further prospective comparative studies are merited to validate these results.