bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features, treatment options and outcomes in primary cutaneous B‐cell lymphomas: a real‐world, multicenter, retrospective study
Authors: Nikolaou Vasiliki , Koumprentziotis Ioannis‐Alexios , Papadavid Evangelia , Patsatsi Aikaterini , Diavati Stavrianna , Tsimpidakis Antonios , Kruger‐Krasagakis Sabine , Doxastaki Aikaterini , Marinos Leonidas , Kaliampou Stella , Gerochristou Maria , Koumourtzis Marios , Pappa Vasiliki , Kypraiou Efrosini , Kouloulias Vassilis , Angelopoulos Konstantinos , Machairas Alexandros , Vassilakopoulos Theodoros , Papadopoulou Vasiliki , Tsamaldoupis Athanasios , Georgiou Elisavet , Koletsa Triantafyllia , Stratigos Alexander , Siakantaris Marina , Angelopoulou Maria 
Published: November 2024

AbstractBackgroundPrimary cutaneous B‐cell lymphomas (PCBCLs) are rare cutaneous neoplasms with limited literature regarding treatment options and associated treatment outcomes. This study aimed to investigate and present real‐world treatment outcomes in patients with PCBCLs.MethodsAll patients with PCBCL who were treated in five major referral centers for cutaneous lymphoma in Greece over 10 years were retrospectively included with their baseline characteristics and treatment‐associated outcomes collected and analyzed.ResultsIn total, 235 PCBCL patients, of whom 125 (53.2%) were females, were included. The median age at diagnosis was 60 years (IQR 47–72), and the median follow‐up duration was 3 years (IQR 1.3–6.4). The most common subtype was primary cutaneous marginal zone lymphoma (PCMZL) (52.3%), followed by primary cutaneous follicle center lymphoma (PCFCL) (40.9%), and primary cutaneous large B‐cell lymphoma, leg type (PCDLBCL, LT) with 16 (6.8%) cases. Complete responses (CRs) were observed in 77.3% after first‐line treatment. Both radiotherapy (RT) and surgical excision (SE) achieved superior outcomes, with 88.9% and 89% achieving CR, respectively. Relapses occurred in 22.6% of initial complete responders. The median time to the next treatment (TTNT) for the PCMZL and PCFCL was 349 days. RT and topical/intralesional steroids demonstrated longer TTNT compared to SE (445 and 359 vs. 154 days). For PCMZL and PCFCL, the 1‐year progression‐free survival (PFS) was 84.2% (75.7–89.9) and 85% (75.1–91.2), and the 5‐year PFS was 66.5% (55.2–75.5) and 58.8% (44.4–70.7), respectively.ConclusionsPCBCLs have favorable outcomes. RT demonstrates significantly increased TTNT compared to SE, suggesting RT as the preferable option. After careful evaluation, “watch and wait” may be a reasonable option for asymptomatic patients.
Survival and Complication Rates of Feldspathic, Leucite‐Reinforced, Lithium Disilicate and Zirconia Ceramic Laminate Veneers: A Systematic Review and Meta‐Analysis
Authors: Klein Patrick , Spitznagel Frank A. , Zembic Anja , Prott Lea S. , Pieralli Stefano , Bongaerts Brenda , Metzendorf Maria‐Inti , Langner Robert , Gierthmuehlen Petra C. 
Published: November 2024

ABSTRACTObjectivesTo analyze survival and complication rates for anterior and premolar laminate‐veneers out of different ceramic materials (feldspathic, leucite‐reinforced glass–ceramic [LRGC], lithium‐disilicate [LDS] and zirconia).Material and MethodsA systematic literature search was conducted across multiple databases for clinical studies on ceramic laminate‐veneers with a minimum‐follow‐up of ≥ 1 year. The date of last search was on February 19, 2024. Survival, technical, esthetic and biological events were assessed for different laminate‐veneer materials at three observation periods (short‐ [1–3 years], mid‐ [4–6 years] and long‐term [≥ 7 years]).ResultsTwenty‐nine studies were included. Meta‐analysis revealed a pooled survival‐rate of 96.13% for feldspathic, 93.70% for LRGC and 96.81% for LDS at 10.4 years. No difference was found between materials. Complication rates (technical/esthetic/biological) were as follows: Feldspathic: 41.48%/19.64%/6.51%; LRGC: 29.87%/17.89%/4.4%; LDS: 6.1%/1.9%/0.45% at 10.4 years. Zirconia showed a 100% survival‐rate with no complications at 2.6 years. No long‐term data was available for zirconia.ConclusionsFeldspathic, LRGC and LDS laminate‐veneers showed high survival‐rates at long‐term observation. LDS slightly outperforms feldspathic and LRGC laminate‐veneers with lower long‐term complication rates. More studies providing long‐term data on zirconia laminate‐veneers are needed.Clinical SignificanceCeramic laminate‐veneers are a reliable treatment option. LDS may be preferred as a restorative material for long‐term success.
The Triple Layer Graft Protocol to Repair Esthetically Compromised Implants: Rationale, Technique, Indications, and Contraindications
Authors: Tarnow Dennis P. , Chu Stephanie M. , Chu Stephen J. 
Published: November 2024

ABSTRACTObjectivesThese two clinical case reports show the use of the Triple Layer Graft procedure along with the Decoronation procedure to help restore normal contour and height of tissue The procedure was highly effective at restoring the esthetics that the patients needed on their implants. Short and long term results along with the step by step technique are shown.Clinical ConsiderationsTwo patients of 33 and 25 years of age both had significant reduction in the height over their implants in the #7 and #10 locations. The first patient had the implants placed 15 years ago and the second patient had them done 5 years before our treatment. Current techniques to remedy esthetic issues created by malpositioned implants consist of soft and/or hard tissue grafting but tend to be utilized independently of each other in discrete procedures as opposed to being combined in one surgical protocol. The Triple Layer Graft (TLG) surgical protocol is novel in that it incorporates all three layers of grafting to address both soft and hard tissue deficits in one procedure done at one time after doing a decoronation technique. The TLG surgical and prosthetic protocol has been previously published by these authors, but this article will discuss the rationale along with the technique and indications and contraindications, illustrated via case reports. The authors will also report on the long‐term results of this technique.ConclusionsThe Triple Layer Graft TLG) in combination with the Decoronation technique is an effective method in managing mild as well as severe esthetic defects over the facial of previously placed implants.Clinical SignificanceThe Triple Layer Graft will allow implants that were previously removed in order to place a new implant along with ridge augmentation may be able to be saved. This is a wonderful procedure for the patient since the implant does not have to be removed and replaced.
Is it beneficial to be a city dweller? Impacts of urban conditions on red fox reproduction
Authors: Jackowiak M. , Jasińska K. D. , Gryz J. , Guzowska E. , Szyc K. , Krauze‐Gryz D. 
Published: November 2024

AbstractVarious species inhabit cities around the world, and numerous changes in their biology can be observed. Among them, changes in the time of reproduction or productivity are often recorded in urban populations. Firstly, we compared selected reproductive features (i.e., litter size and time of breeding) of two red fox (Vulpes vulpes) populations, one living in the city of Warsaw and the other inhabiting a forest‐field mosaic in Central Poland. Secondly, we investigated fox reproductive and social behaviour in an extensive camera trap study in Warsaw (2018–2021). By means of generalized linear mixed effects models, we identified which factors (fox social group size, share of natural food, and level of urbanization, created by using principal components analysis for habitat and landscape variables) affected the reproduction and/or social group size of urban foxes. We found that urban foxes started breeding about 2 weeks earlier than their rural counterparts and produced bigger litters (3.98 vs. 3.48 cubs). Opposite to rural foxes where only pairs of adult foxes were reported, in the urban population, social groups were observed with a mean number of 2.37 individuals. Interestingly, none of the studied factors affected group size or litter size in urban foxes, while breeding time was influenced by the level of urbanization and share of natural food. Earlier reproduction in urban areas is fairly frequently observed and may be attributed to altered environmental conditions in urban habitats, while higher productivity is probably a consequence of higher food availability.
Contribution of disease to Australian sea lion (Neophoca cinerea) pup mortality at Seal Bay, Kangaroo Island, 2016–2022
Authors: Lindsay Scott A. , Fulham Mariel , Stonnill Melanie , Caraguel Charles G. B. , Gray Rachael 
Published: November 2024

AbstractThe endangered Australian sea lion (Neophoca cinerea) population is declining, and its conservation is threatened by the species' low fecundity and high pup mortality. This study details reasons for pup deaths and quantifies the impacts of disease and comorbidity. Of 284 dead pups reported from five breeding seasons (2016–2022) at the Seal Bay colony, Kangaroo Island, gross necropsy was conducted on 122, with fecal analysis for hookworm (Uncinaria sanguinis) detection, tissue histology, and bacterial culture performed on subsets. Determinable primary causes of mortality were conspecific trauma (± comorbidity, 41.0%), starvation (24.6%), and infectious disease (hookworm‐associated hemorrhagic enteritis [HAHE] ± bacterial infection, 19.7%). Allowing for comorbidity, 37.7% of pups died with an infectious disease, including 44.0% of deaths with trauma and 41.5% with starvation. In higher mortality summer‐autumn breeding seasons, pups were at greater risk of trauma (p = .001) and subsequent bacterial infection (p < .001). Parasiticide treatment significantly reduced HAHE‐associated (p = .005) and overall mortality (p < .001) risk, suggesting hookworm infection increases pup susceptibility to other causes of mortality. Although the exact causal pathways for this treatment‐related overall mortality benefit remain to be confirmed, intervention appears highly impactful and could benefit species conservation efforts.
Multisensory stimulation to reduce procedural pain in retinopathy of prematurity: A randomized controlled trial
Authors: Tasdemir Halil Ibrahim 
Published: November 2024

AbstractBackgroundRetinopathy is frequently seen in the neonatal intensive care unit (NICU), and its examination is a painful procedure for infants.AimThis randomized active‐controlled trial aimed to investigate the impact of multisensory stimulation (MSS) on neonatal pain during retinopathy of prematurity (ROP) examinations, in comparison with a white noise (WN) and control group receiving standard care.Study DesignConducted as a three‐arm, randomized controlled trial, the study was implemented in the NICU of a local university hospital. Recruitment spanned from July 2023 to November 2023, with preterm infants (gestational age < 37 weeks) randomly assigned to either a MSS, WN or a control group. MSS components included visual, auditory, tactile, olfactory and gustatory stimuli, all designed to create a synergistic, comforting environment for the infant during the procedure. Procedural pain, heart rate and oxygen saturation were assessed at various stages before and after ROP examinations.ResultsAnalysis of 90 participants revealed that the MSS group exhibited lower Premature Infant Pain Profile (PIPP) scores than the WN and control groups (mean difference: −2.12, 95% confidence interval [CI]: −2.62 to −1.62; odds ratio [OR]: 0.004, 95% CI [0.001, 0.012], p < 0.001). Additionally, heart rates were significantly lower in the MSS group (mean difference: −15.3 beats/min, 95% CI: −20.5 to −10.1; OR: 0.025, 95% CI [0.008, 0.073], p < .001) and oxygen saturation levels were higher (mean difference: 3.2%, 95% CI: 1.8% to 4.6%; OR: 1.12, 95% CI [1.05, 1.20], p < .001) than in the other groups.ConclusionsMSS emerges as a favourable, safe and non‐pharmacological intervention for pain management in ROP and similar procedures.Relevance to Clinical PracticeMultisensory stimulation can be effectively integrated into the routine care provided by critical care nurses during retinopathy of prematurity examinations in preterm infants. This non‐pharmacological intervention offers a practical approach for critical care nurses to reduce procedural pain and improve physiological stability in this vulnerable population.
The association between composite measures of social vulnerability and PICU admission for status asthmaticus
Authors: Jones Justin , Klein Margaret J. , Adiwidjaja Alicia , Ross Patrick , Keefer Matthew , Tan Jonathan M. 
Published: November 2024

AbstractBackgroundCurrent knowledge of the impact of socioeconomic factors on the risk of admission to the pediatric intensive care unit (PICU) for asthma is limited. Using composite measures of social vulnerability—Social Vulnerability Index (SVI) and Child Opportunity Index (COI) 2.0—we compared patients admitted for status asthmaticus to the PICU and pediatric ward at Children's Hospital Los Angeles (CHLA). We hypothesized patients with a high SVI and low COI are at higher risk for PICU admission.MethodsPatients were identified using ICD‐10 codes for asthma. Primary outcome was admission to PICU versus ward for status asthmaticus. Patient‐registered residential street addresses were geocoded and spatially joined to SVI and COI 2.0 data at the census tract level. Univariate and regression analyses using the patient's SVI, COI 2.0, and admission location were conducted.ResultsFrom January 2017 to March 2022, there were 2458 admissions matched to addresses from 1983 distinct patients. The overall median SVI for all patients was 0.86 (IQR 0.6, 0.9). Overall median COI was 25.0 (IQR 10, 50). There was no difference in SVI or COI for admission to the PICU versus the ward. However, children requiring multiple hospital admissions for asthma were associated with higher SVI and lower COI.ConclusionsChildren admitted to CHLA for asthma had an elevated SVI and low COI. There was no difference between admission locations based on SVI or COI scores. This indicates we care for children at increased socioeconomic risk, but this did not increase PICU use for asthma.
The need for general adaptive capacity—Discussing resilience with complex adaptive systems theory
Authors: Scharte Benjamin 
Published: November 2024

AbstractThe concept of resilience intrinsically links with both complexity and adaptive capacity. Scholars from different fields agree on this. Still, the detailed relations between resilience, complexity, and adaptive capacity need a more thorough theoretical analysis. This article analyses resilience with the help of assumptions from complex adaptive systems (CAS) theory to answer two questions in more detail: What is the relation between resilience and complexity? How can adaptive capacity contribute to resilience? By applying basic ideas from CAS theory to the resilience discourse, the article deduces that complexity of a system is a necessary condition for resilience because complex systems consist of agents that possess adaptive capacity, whereas simple systems consist of mere elements that cannot adapt to unexpected disruptions. The relation between complexity and resilience is multidimensional. Growing complexity leads to a growing need for resilience because the chances for severe, unexpected disruptions increase. The analysis of adaptive capacities revealed that systems and the agents they consist of can possess of specialized and general adaptive capacity. General adaptive capacity is the core feature of resilience because it enables systems to cope with unexpected disruptions. System design principles such as diversity within functional groups and redundancy help to increase general adaptive capacity. The same is true on the community level for social capital and on the individual level for disaster preparedness measures because they increase coping capacities independent of specific hazards.
Exploring the Mechanisms of the Development of Social Welfare Policies for Vulnerable Children in China—A Multicase Study
Authors: Chen Renxing , Zhu Lin , Lu Ying 
Published: November 2024

ABSTRACTWith China's shift from its planned economy to a market economy in the early 1980s, followed by the tremendous socioeconomic changes in the 1990s and beyond that were initiated by the reform and opening‐up, vulnerable children have emerged as a growing population. In response to the rising needs of those vulnerable children, the Chinese government has developed a series of social welfare policies (SWPs). However, few studies have examined the policymaking processes and the mechanisms for forming and changing China's SWPs for vulnerable children. Therefore, to bridge that research gap we have focused in this study on the agenda‐setting of SWPs for vulnerable children in China. We selected the Multiple Streams Framework (MSF) as our conceptual framework, and we used the process‐tracing approach to analyse the mechanisms of China's SWP development for vulnerable children. Using a multicase study, we found that a specific ‘focusing event’ formed a problem stream in each case. Then, helped by the media and the Internet, those focusing events triggered the national mood and shaped public opinion, which in turn formed a politics stream. Feeling growing pressure from the public, political leaders assigned tasks via written instructions intended to solve the problems and ensure that local governments act immediately. Hence, written instructions became a policy stream, and political leaders were the policy entrepreneurs. This article contributes to the theory by examining the MSF with China's cases and then modifying the framework with Chinese characteristics.
Comparison of Policy Responses to the COVID‐19 Pandemic. Does It Reproduce the Old Patterns?
Authors: Piłat Adam 
Published: November 2024

ABSTRACTThe research's main objectives are to verify systemic differences between OECD countries in terms of their early responses to the COVID‐19 economic challenge and to compare newly established taxonomy with old patterns determined by classifications that can be found in the literature. Research is based on a few methods of cluster analysis—hierarchical clustering and the k‐means method are supplemented with insights derived from the application of c‐means fuzzy clustering. It also applies Rand and Jaccard indices to compare a new taxonomy with existing classifications of welfare states and capitalistic systems. Objective comparison of the new taxonomy with those existing in the literature with the application of statistical methods is the most significant contribution of the article. Results suggest that it is possible to distinguish various strategies for dealing with the COVID‐19 economic consequences in the early period of the pandemic, but demarcation lines between particular clusters significantly differ from the findings of previous studies.
Immunological Pre‐Metastatic Niche in Dogs With Naturally Occurring Osteosarcoma
Authors: Kerboeuf Mikael , Anfinsen Kristin Paaske , Koppang Erling Olaf , Lingaas Frode , Argyle David , Teige Jon , Sævik Bente Kristin , Moe Lars 
Published: November 2024

ABSTRACTPre‐metastatic niche (PMN) formation is essential for metastatic development and drives organotropism. Tumour‐derived extracellular vesicles and soluble factors remodel the microenvironment of distant metastatic organs before subsequent metastasis. Dogs with osteosarcoma (OS) have proven to be excellent disease models for their human companions. Here, we show evidence of PMN formation in dogs with OS before metastasis. We necropsied and sampled lung tissues from dogs with naturally occurring treatment‐naïve OS (n = 15) and control dogs without cancer (n = 10). We further divided dogs with OS into those having lung metastases (n = 5) and those without (n = 10). We stained formalin‐fixed paraffin‐embedded tissues using multiplex immunofluorescence to quantify the number of bone marrow‐derived cells, monocytes and macrophages in the lung samples from each dog. The numbers of CD204+ macrophages, CD206+ macrophages and monocytes and CD11d+ bone marrow‐derived cells (BMDCs) were significantly higher in the pre‐metastatic lung of dogs with OS (n = 10) than in control dogs without cancer (n = 10). Furthermore, the total nucleated cell (DAPI+) density was higher before metastasis than in healthy lungs. In dogs with established metastases, the number of CD11d+ BMDCs was significantly lower than in the pre‐metastatic lung, suggesting this recruitment is transient. Our study provides evidence of PMN existence in a naturally occurring cancer model similar to those observed in pre‐clinical murine models. BMDCs are recruited to the lungs before metastases have developed. Dogs with OS may represent ideal candidates for assessing new PMN‐targeting therapies.
Effect of Aerobic Exercises on Ventilatory Functions in Women With Rheumatoid Arthritis: A Randomized Controlled Trial
Authors: Elgayar Saher Lotfy 
Published: November 2024

The goal of this research was to investigate the effects of aerobic exercises (AEs) on ventilatory functions, chest expansion, exercise capacity, and quality of life in women with rheumatoid arthritis. A total of 66 women diagnosed with rheumatoid arthritis were assigned randomly to two groups of the same size. Over a period of 12 weeks, the AE group engaged in aerobic workouts of moderate-to-high intensity, three times per week, along with diaphragmatic breathing exercises, whereas the control group only received diaphragmatic breathing exercises. Outcome measures included forced vital capacity, forced expiratory volume in the first second, total lung capacity, upper and lower chest expansions, maximal oxygen consumption, physical component score, and mental component score components of the 12-item Short Form Health Survey. Compared with baseline measurements, the AE and control groups exhibited substantial improvements in all outcomes by the completion of the trial (p < .05). Compared with the controls, the AE group revealed substantial increases in forced vital capacity (10.2% vs. 4.8%, p = .02), forced expiratory volume in the first second (8.9% vs. 4.07%, p = .01), total lung capacity (10.86% vs. 5.35%, p = .008), upper chest expansion (21.37% vs. 11.71%, p = .04), lower chest expansion (28.33% vs. 10.63%, p = .03), maximal oxygen consumption (30.7% vs. 15.01%, p = .01), physical component score (17.68% vs. 11.04%, p = .003), and mental component score (25.65% vs. 13.21%, p = .01). In women with rheumatoid arthritis, the addition of moderate-to-high AE to diaphragmatic breathing exercises could improve ventilatory functions, chest expansion, exercise capacity, and quality of life.