bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of Patient Symptoms With Labral and Articular Cartilage Damage in Femoroacetabular Impingement
Authors: Grace Trevor , Samaan Michael A. , Souza Richard B. , Link Thomas M. , Majumdar Sharmila , Zhang Alan L. 
Published: June 2018

Background: Femoroacetabular impingement (FAI) can lead to labral and articular cartilage injuries as well as early osteoarthritis of the hip. Currently, the association of patient symptoms with the progression of labral and articular cartilage injuries due to FAI is poorly understood. Purpose: To evaluate the correlation between patient-reported outcome (PRO) scores and cartilage compositional changes seen on quantitative magnetic resonance imaging (MRI) as well as cartilage and labral damage seen during arthroscopic surgery in patients with FAI. Study Design: Cohort study; Level of evidence, 3. Methods: Patients were prospectively enrolled before hip arthroscopic surgery for symptomatic FAI. Patients were included if they had cam-type FAI without radiographic arthritis. All patients completed PRO scores, including the Hip disability and Osteoarthritis Outcome Score (HOOS) and a visual analog scale for pain. MRI with mapping sequences (T1ρ and T2) on both the acetabular and femoral regions was performed before surgery to quantitatively assess the cartilage composition. During arthroscopic surgery, cartilage and labral injury grades were recorded using the Beck classification. Pearson and Spearman correlation coefficients were then obtained to evaluate the association between chondrolabral changes and PRO scores. Results: A total of 46 patients (46 hips) were included for analysis (mean age, 35.5 years; mean body mass index [BMI], 23.9 kg/m2; 59% male). Increasing BMI was correlated with a more severe acetabular cartilage grade (ρ = 0.37; 95% CI, 0.08-0.65). A greater alpha angle was correlated with an increased labral tear grade (ρ = 0.59; 95% CI, 0.37-0.82) and acetabular cartilage injuries (ρ = 0.61; 95% CI, 0.42-0.80). With respect to PRO scores, increasing femoral cartilage damage in the anterosuperior femoral head region, as measured on quantitative MRI using T1ρ and T2 mapping, correlated with lower (worse) scores on the HOOS Activities of Daily Living ( r = 0.35; 95% CI, 0.06-0.64), Symptoms ( r = 0.32; 95% CI, 0.06-0.57), and Pain ( r = 0.31; 95% CI, 0.06-0.55) subscales. There was no correlation between PRO scores and acetabular cartilage damage or labral tearing found on quantitative MRI or during arthroscopic surgery. Conclusion: Femoral cartilage damage, as measured on T1ρ and T2 mapping, appears to have a greater correlation with clinical symptoms than acetabular cartilage damage or labral tears in patients with symptomatic FAI.
An anatomically‐based masking protocol for the assessment of in‐shoe plantar pressure measurement of the forefoot
Authors: Forghany Saeed , Bonanno Daniel R. , Menz Hylton B. , Landorf Karl B. 
Published: June 2018

AbstractBackgroundThe area beneath the metatarsal heads is a common location of foot pain, which is often associated with high plantar pressures. Current plantar pressure assessment protocols focus mainly on the gross area of the forefoot with minimal attention paid to specific areas such as the metatarsal heads. The aim of this study was to develop and assess a new anatomically‐based masking protocol that is clinically relevant to measure forefoot plantar pressure during shod conditions based on the anatomical positions of the metatarsal heads.MethodsInitially, we developed a masking protocol to measure forefoot plantar pressure during shod conditions based on the anatomical positions of the metatarsal heads. This new masking protocol divided the forefoot into three sub‐areas (proximal, beneath, and distal to the metatarsal heads) as determined by the position of each metatarsal head. Following development of the new masking protocol, we compared the new protocol against a traditional protocol, which defines the forefoot as between 51 and 81% of the foot length. To compare the two masking protocols, we tested two experimental conditions: (i) a control condition (i.e. no metatarsal pad), and (ii) a metatarsal pad condition. We then compared plantar pressure differences between the two experimental conditions for the two masking protocols. Participants for this component of the study included 36 community dwelling older adults (mean age 75.6 years ±5.4) with a history of forefoot pain. Forefoot plantar pressure data were measured while walking using the pedar®‐X in‐shoe system. Peak pressure, maximum force and contact area at the time of peak pressure were determined and results were compared between the two masking protocols.ResultsThe traditional masking protocol showed that the metatarsal pad significantly decreased peak pressure and increased contact area in the forefoot area (i.e. within the entire mask area), but maximum force was not significantly different between the two conditions. In contrast, the newly developed anatomically‐based masking protocol indicated that the metatarsal pad decreased peak plantar pressures distal to and beneath the metatarsal heads by increasing force and contact area proximal to the metatarsal heads.ConclusionsAn anatomically‐based masking protocol that is clinically relevant was developed to assess forefoot plantar pressure during shod conditions based on the anatomical positions of metatarsal heads. We propose that the new forefoot masking protocol will provide greater interpretability of forefoot plantar pressure data, which will aid clinicians and researchers for diagnostic, prognostic and therapeutic purposes.
Optimal transport for mitigating cycle skipping in full-waveform inversion: A graph-space transform approach
Authors: Métivier Ludovic , Allain Aude , Brossier Romain , Mérigot Quentin , Oudet Edouard , Virieux Jean 
Published: June 2018

Optimal transport distance has been recently promoted as a tool to measure the discrepancy between observed and seismic data within the full-waveform-inversion strategy. This high-resolution seismic imaging method, based on a data-fitting procedure, suffers from the nonconvexity of the standard least-squares discrepancy measure, an issue commonly referred to as cycle skipping. The convexity of the optimal transport distance with respect to time shifts makes it a good candidate to provide a more convex misfit function. However, the optimal transport distance is defined only for the comparison of positive functions, while seismic data are oscillatory. A review of the different attempts proposed in the literature to overcome this difficulty is proposed. Their limitations are illustrated: Basically, the proposed strategies are either not applicable to real data, or they lose the convexity property of optimal transport. On this basis, we introduce a novel strategy based on the interpretation of the seismic data in the graph space. Each individual trace is considered, after discretization, as a set of Dirac points in a 2D space, where the amplitude becomes a geometric attribute of the data. This ensures the positivity of the data, while preserving the geometry of the signal. The differentiability of the misfit function is obtained by approximating the Dirac distributions through 2D Gaussian functions. The interest of this approach is illustrated numerically by computing misfit-function maps in schematic examples before moving to more realistic synthetic full-waveform exercises, including the Marmousi model. The better convexity of the graph-based optimal transport distance is shown. On the Marmousi model, starting from a 1D linearly increasing initial model, with data without low frequencies (no energy less than 3 Hz), a meaningful estimation of the P-wave velocity model is recovered, outperforming previously proposed optimal-transport-based misfit functions.
Are we there yet?
Authors: Fadden Gráinne 
Published: June 2018

SUMMARYBurbach describes the content of a phased approach to delivering family work in psychosis. Clinicians would find it helpful to have guidance on how to address the challenges they face in clinical practice, such as engaging all family members in the process and how to deal with confidentiality conflicts. Implementation challenges are also likely to affect their ability to deliver this intervention. It may also be useful to consider the role that family members can play in co-production and training, and in delivering support to other families through a carer peer support model.DECLARATION OF INTERESTNone.
APC/CFzr regulates cardiac and myoblast cell numbers, and plays a crucial role during myoblast fusion
Authors: Drechsler Maik , Meyer Heiko , Wilmes Ariane C. , Paululat Achim 
Published: June 2018

ABSTRACT
Somatic muscles are formed by the iterative fusion of myoblasts into muscle fibres. This process is driven by the recurrent recruitment of proteins to the cell membrane to induce F-actin nucleation at the fusion site. Although several proteins involved in myoblast fusion have been identified, knowledge about their subcellular regulation is rather elusive. We identified the anaphase-promoting complex (APC/C) adaptor Fizzy related (Fzr) as an essential regulator of heart and muscle development. We show that APC/CFzr regulates the fusion of myoblasts as well as the mitotic exit of pericardial cells, cardioblasts and myoblasts. Surprisingly, overproliferation is not causative for the observed fusion defects. Instead, fzr mutants exhibit smaller F-actin foci at the fusion site and display reduced membrane breakdown between adjacent myoblasts. We show that lack of APC/CFzr causes accumulation and mislocalisation of Rols and Duf, two proteins involved in the fusion process. Duf seems to serve as direct substrate of the APC/CFzr and its destruction depends on the presence of distinct degron sequences. These novel findings indicate that protein destruction and turnover constitute major events during myoblast fusion.
ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels
Authors: Peralta Susana , Goffart Steffi , Williams Sion L. , Diaz Francisca , Garcia Sofia , Nissanka Nadee , Area-Gomez Estela , Pohjoismäki Jaakko , Moraes Carlos T. 
Published: June 2018

ABSTRACT
Mutations in the mitochondrial inner membrane ATPase ATAD3A result in neurological syndromes in humans. In mice, the ubiquitous disruption of Atad3 (also known as Atad3a) was embryonic lethal, but a skeletal muscle-specific conditional knockout (KO) was viable. At birth, ATAD3 muscle KO mice had normal weight, but from 2 months onwards they showed progressive motor-impaired coordination and weakness. Loss of ATAD3 caused early and severe mitochondrial structural abnormalities, mitochondrial proliferation and muscle atrophy. There was dramatic reduction in mitochondrial cristae junctions and overall cristae morphology. The lack of mitochondrial cristae was accompanied by a reduction in high molecular weight mitochondrial contact site and cristae organizing system (MICOS) complexes, and to a lesser extent in OPA1. Moreover, muscles lacking ATAD3 showed altered cholesterol metabolism, accumulation of mitochondrial DNA (mtDNA) replication intermediates, progressive mtDNA depletion and deletions. Unexpectedly, decreases in the levels of some OXPHOS components occurred after cristae destabilization, indicating that ATAD3 is not crucial for mitochondrial translation, as previously suggested. Our results show a critical early role of ATAD3 in regulating mitochondrial inner membrane structure, leading to secondary defects in mtDNA replication and complex V and cholesterol levels in postmitotic tissue.
This article has an associated First Person interview with the first author of the paper.
What to expect from electronic patient record system implementation: lessons learned from published evidence
Authors: Priestman Ward , Sridharan Shankar , Vigne Helen , Collins Richard , Seamer Loretta , Sebire Neil J. 
Published: June 2018

BackgroundNumerous studies have examined factors related to success, failure and implications of electronic patient record (EPR) system implementations, but usually limited to specific aspects.ObjectiveTo review the published peer-reviewed literature and present findings regarding factors important in relation to successful EPR implementations and likely impact on subsequent clinical activity.MethodLiterature review.ResultsThree hundred and twelve potential articles were identified on initial search, of which 117 were relevant and included in the review. Several factors were related to implementation success, such as good leadership and management, infrastructure support, staff training and focus on workflows and usability. In general, EPR implementation is associated with improvements in documentation and screening performance and reduced prescribing errors, whereas there are minimal available data in other areas such as effects on clinical patient outcomes. The peer-reviewed literature appears to under-represent a range of technical factors important for EPR implementations, such as data migration from existing systems and impact of organisational readiness.ConclusionThe findings presented here represent the synthesis of data from peer-reviewed literature in the field and should be of value to provide the evidence-base for organisations considering how best to implement an EPR system.
Learning health systems need to bridge the ‘two cultures’ of clinical informatics and data science
Authors: Scott Philip J. , Dunscombe Rachel , Evans David , Mukherjee Mome , Wyatt Jeremy C. 
Published: June 2018

BackgroundUK health research policy and plans for population health management are predicated upon transformative knowledge discovery from operational ‘Big Data’. Learning health systems require not only data, but feedback loops of knowledge into changed practice. This depends on knowledge management and application, which in turn depends upon effective system design and implementation. Biomedical informatics is the interdisciplinary field at the intersection of health science, social science and information science and technology that spans this entire scope.IssuesIn the UK, the separate worlds of health data science (bioinformatics, ‘Big Data’) and effective healthcare system design and implementation (clinical informatics, ‘Digital Health’) have operated as ‘two cultures’. Much National Health Service and social care data is of very poor quality. Substantial research funding is wasted on ‘data cleansing’ or by producing very weak evidence. There is not yet a sufficiently powerful professional community or evidence base of best practice to influence the practitioner community or the digital health industry.RecommendationThe UK needs increased clinical informatics research and education capacity and capability at much greater scale and ambition to be able to meet policy expectations, address the fundamental gaps in the discipline’s evidence base and mitigate the absence of regulation. Independent evaluation of digital health interventions should be the norm, not the exception.ConclusionsPolicy makers and research funders need to acknowledge the existing gap between the ‘two cultures’ and recognise that the full social and economic benefits of digital health and data science can only be realised by accepting the interdisciplinary nature of biomedical informatics and supporting a significant expansion of clinical informatics capacity and capability.
Can we trust electronic health records? The smoking test for commission errors
Authors: Millares Martin Pablo 
Published: June 2018

BackgroundConsiderable interest exists on using general practice electronic health records (EHRs) for research and other uses. There is also concern on their quality.AimWe suggest a simple test to assess errors of commission and subsequently overall EHR data quality that can be done on a periodical basis.MethodPatient records with simultaneous entries of three different stages on smoking were studied. The codes ‘never smoked tobacco’, ‘smoker’ and ‘ex-smoker’ should follow this chronological order. It should then be possible to extrapolate the overall level of errors of commission for the organisation.ResultsThe smoking test in our sample found errors in 169 patients, with 60 cases where dual errors were discovered. We express it as an estimated error of commission level of 2.6% related to the total population of the practice.ConclusionsConsidering the constant and regular entries on smoking status (83.59% of the entries were done over last month), we can conclude smoking entries analysis can serve as a simple test to periodically assess the overall EHR data quality, and any trends.
A regression error specification test (RESET) for the truncated regression model
Authors: Sapra Sunil 
Published: June 2018

While a variety of specification tests are routinely employed to test for misspecification in linear regression model, such tests and their applications to the truncated and censored regression models are uncommon. This paper develops a regression error specification test (RESET) for the truncated regression model as an extension of the popular RESET for the linear regression model (Ramsey (1969)). The two proposed extensions TRESET1 and TRESET2 developed in the paper are applied to labor force participation data from Mroz (1987). The paper studies the empirical size and power properties of the proposed tests via Monte Carlo experiments. Our simulation results suggest that both TRESET tests have reasonably good size and power properties for the truncated regression model in medium to large samples. However, TRESET2 consistently outperforms TRESET1 both in terms of empirical size and power in our experiments.Â Â
Zur Verbvalenz des sumerischen Ausdruckes nir ĝal2
Authors: Ceccarelli Manuel 
Published: June 2018

AbstractThe aim of this article is to study the verb valency of the Sumerian expression nir ĝal2. The attestations point to two different meanings that are related to different arguments. It is suggested that the basic meaning of nir ĝal2 is „to give off an aura of authority; show authority“. The comitative argument indicates thanks to whom, the ablative argument by means of what someone shows authority. The meaning „to trust“ would result from a valency expansion, which can be traced to at least the beginning of the second millennium and could have been influenced by the construction of the Akkadian verb takālu „to trust“. The object of trust is expressed by means of the terminative (things) and dative (persons) arguments. The locative is mostly used as a peripheral argument expressing the place or situation in which someone shows authority.
Sapaziti, Sapalulme und die Suppiluliumas von W/Pal(a)stin(a/i)
Authors: Simon Zsolt 
Published: June 2018

AbstractThis paper argues that the Neo-Assyrian spelling Sapalulme of a Neo-Hittite ruler does not represent a distortion of the name Suppiluliuma (as it is generally assumed), but a relatively close transcription of another Luwian name, the first member of which may be attested in the name of Sapa-ziti, Great King of Karkamiš. Since the name PURUS.FONS.MI of the statue of Suppiluliuma from Tall Taʿyīnāt cannot be read as Sapalulme, Suppiluliuma of the statue and Sapalulme cannot be identical rulers, contrary to the widespread view.
The Effects of Repeated Sprints on the Kinematics of 3-Point Shooting in Basketball
Authors: Slawinski Jean , Louis Julien , Poli Julien , Tiollier Eve , Khazoom Charles , Dinu Daniel 
Published: June 2018

Abstract
Fatigue modifies the kinematics of various sports-related movements. Basketball induces fatigue, however, the effects of fatigue on the kinematics of shooting have never been studied. This study analysed the effects of fatigue induced by repeated sprints on the kinematics of 3-point shooting (3PS) in young, elite basketball players (U18 level). 3D joint angles were calculated at the maximum and minimum heights of the centre of mass during 3PS, using inertial measurement units (Biomech system, Xsens Technologies BV, Enschede, The Netherlands). Height, velocity and the angle of the ball at the time of release were extrapolated from the wrist joint angles. All players performed four 3PS actions in dynamic conditions before and after a fatigue protocol at 70% of their maximal exercise capacity. The fatigue protocol consisted of a shuttle test with repeated 20-m sprints interspersed with sets of 5 jumps. There was no change in the kinematics of 3PS (p > 0.05), or the ball release variables (p > 0.05) following the fatigue protocol. This suggests that elite basketball players are able to cope with physical fatigue while performing coordinated movements such as 3PS.
Changes in Injury Risk Mechanisms After Soccer-Specific Fatigue in Male Youth Soccer Players
Authors: Lehnert Michal , Croix Mark De Ste , Xaverova Zuzana , Botek Michal , Varekova Renata , Zaatar Amr , Lastovicka Ondrej , Stastny Petr 
Published: June 2018

Abstract
The aim of this study was to examine the acute effects of soccer specific fatigue on muscular and neuromuscular function in male youth soccer players. Elite soccer players (n = 20; age 15.7 ± 0.5 y; body height 177.75 ± 6.61 cm; body mass 67.28 ± 8.29 kg) were measured before and after soccer specific exercise (SAFT90). The reactive strength index (RSI) was determined by a drop jump test, leg stiffness (LS) by a 20 sub-maximal two-legged hopping test, and a functional hamstring to quadriceps strength ratio from isokinetic concentric and eccentric strength of the dominant and non-dominant leg (measured at angular velocities of 1.05 rad · s−1 and 3.14 rad · s−1). Metabolic response to the SAFT90 was determined by blood lactate and perceived exertion was assessed by the Borg scale. After simulated match play, a significant decrease in absolute LS (t = 4.411; p < 0.001; ω2 = 0.48) and relative LS (t = 4.326; p < 0.001; ω2 = 0.49) was observed and the RSI increased significantly (t = 3.806; p = 0.001; ω2 = 0.40). A reduction in LS found after the SAFT90 indicates possible reduction in dynamic knee stabilization. However, if we consider the changes in other observed variables, the present study did not clearly confirm that fatigue induced by a soccer specific protocol increased the risk of ACL and hamstring injury. This may be attributed to the simulated rather than actual match play used in the present study.
Skeletal Muscle Cell Damage Indicators in Volleyball Players after the Competitive Phase of the Annual Training Cycle
Authors: Radojewski Mateusz , Podgórski Tomasz , Pospieszna Barbara , Kryściak Jakub , Śliwicka Ewa , Karolkiewicz Joanna 
Published: June 2018

AbstractThe aim of the study was to evaluate the impact of the competitive phase on physiological and metabolic indices and selected markers of skeletal muscle damage in male volleyball players. The study group consisted of 24 young male volleyball players. During the study, participants underwent two series of measurements, before and after the competitive phase of the annual training cycle. In both study terms, players performed an incremental treadmill running test to determine their ventilatory threshold and maximal oxygen uptake. Venous and capillary blood samples were taken for biochemical analysis. There was no significant difference in the physical fitness level, values of biochemical variables and the level of antioxidant status in the surveyed athletes between the two study terms. Significant changes within skeletal muscle damage markers were observed between the beginning and the end of the competitive period: an increase in the concentration of cellular DNA damage products (8-hydroxy-2′-deoxyguanosine; p < 0.0001) and a decrease in muscle activity of creatine kinase (p<0.05). In spite of the increment in cell damage markers, the unaffected level of physiological and biochemical markers may indicate that the experienced cell destruction did not negatively affect the level of physical fitness. When designing the annual training plan, coaches and athletes need to take into consideration that temporary physiological states – oxidative stress and inflammation – may be required to attain training adaptation.