bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transparantie van kwaliteitsoordelen
Authors: Bokhorst Meike , van Erp Judith 
Published: June 2018

Transparantie van kwaliteitsoordelen. Van instrumenteel naar responsief toezicht
Veel toezichthouders streven naar ‘transparantie’, maar hoe dit in de praktijk vorm moet krijgen, is niet altijd evident. Bestaand onderzoek naar transparantie heeft zich vooral gericht op de effecten van openbaarmaking van toezichtinformatie op gedrag van ondertoezichtgestelden. Dit artikel presenteert een breder analysekader, waarin we onderscheid maken tussen transparantie (openbaar maken), verantwoording (oordeel mogelijk maken) en responsiviteit (reactie en dialoog). We passen dit kader toe op de openbaarheidsstrategie van de Inspectie Gezondheidszorg en Jeugd en de Inspectie van het Onderwijs ten aanzien van de openbaarmaking van kwaliteitsoordelen over instellingen. Bij beide inspecties zien we een ontwikkeling in de tijd van transparantie naar verantwoording naar responsiviteit. Het analysekader kan ook voor andere toezichthouders behulpzaam zijn bij het maken van afwegingen ten aanzien van het delen van informatie met hun stakeholders.
Nieuwe bevoegdheden van de Inspectie Gezondheidszorg en Jeugd in oprichting
Authors: Duijkersloot Ton , Koelewijn Alina , Top Karen 
Published: June 2018

Nieuwe bevoegdheden van de Inspectie Gezondheidszorg en Jeugd in oprichting. Adequate rechtsbescherming voor zorgaanbieders gewaarborgd?
In deze bijdrage wordt ingegaan op de nieuwe aanwijzingsbevoegdheid van de Inspectie Gezondheidszorg en Jeugd i.o. ten aanzien van de organisatiestructuur van zorgaanbieders op grond van de Wet kwaliteit, klachten en geschillen in de zorg en op de wettelijke grondslag die is gecreëerd in de Gezondheidswet voor het actief openbaar maken van bepaalde toezichtgegevens door de Inspectie Gezondheidszorg en Jeugd i.o. Is bij deze nieuwe bevoegdheden de rechtsbescherming van zorgaanbieders door de bestuursrechter op adequate wijze gewaarborgd? Zijn in het bijzonder de waarborgen van de artikelen 6 en 8 EVRM gerespecteerd? Naar het oordeel van de auteurs kan dit worden betwijfeld en ligt hier een taak voor de wetgever.
Determination of Aflatoxins in Edible Oils from China and Ethiopia Using Immunoaffinity Column and HPLC-MS/MS
Authors: Chen Lingyun , Molla Alemu Eshetie , Getu Kassa Metsehet , Ma Ande , Wan Chengsong 
Published: June 2018

Abstract
Background: Aflatoxin (AF) ingestion through contaminated foodstuffs causes at least 250 000 deaths every year from hepatocellular carcinoma in China and sub-Saharan Africa. Objective: The main objective of the study was to determine the aflatoxin levels of oils in South Gondar, Ethiopia, and oils purchased from retail markets in Guangzhou, China. Methods: We used a rapid, sensitive, and selective HPLC-tandem mass spectrometry (MS/MS) method for the determination of aflatoxins in edible oils from China and Ethiopia using immunoaffinity column cleaning. Results: The level of contamination for Ethiopian oils ranged between 0.07 and 145.59 μg/kg for total aflatoxins. Of the 27 edible oil samples from Guangzhou, China, the total concentration of aflatoxins (AFB1 + AFB2 + AFG1 + AFG2) ranged between 0.03 and 2.23 μg/kg. Conclusions: The study concluded that the peanut oils from Ethiopia were contaminated with aflatoxins higher than the allowable limit set by many countries while the oils from China were safe for human consumption. Highlights: We first describe an HPLC-MS/MS method for the determination of aflatoxins in 48 edible oil samples from China and Ethiopia using immunoaffinity column cleaning. This is the first preliminary study done on Ethiopian edible oils, giving policy-makers and future researchers baseline data. It is also used to assess the aflatoxin levels of the Chinese edible oils from Guangzhou. Therefore, conducting a comparative study points out the severity of the problem and helps to formulate a new national standard for policy-makers, making this study imperative.
Green building: inovação sustentável?
Authors: Martins Daniel Felipe Victor , Da Silva Washington Luiz Martins , Santos Alexandre Rodrigues 
Published: June 2018

Este artigo propôs investigar o Green Building (GB), enquanto inovação sustentável. O corpus da pesquisa foi orientado a partir de 3 dimensões fundamentais do desenvolvimento sustentável, dentre as quais destacam-se: a dimensão econômica, a dimensão ambiental e a dimensão social. Para a condução da pesquisa, foram definidas entrevistas com os gestores de uma empresa da construção civil com know-how em obras com certificação verde, denominada ficticiamente de ABC, além de alguns dos seus clientes. Metodologicamente foi utilizada a abordagem de natureza qualitativa, instrumentalizada a partir de entrevistas semi-estruturadas que vieram a ser interpretadas e analisadas com o apoio da técnica denominada de Análise de Conteúdo (AC). A pesquisa concluiu que o GB pode ser considerado como uma inovação sustentável, visto que engloba as dimensões propostas pela noção de desenvolvimento sustentável, além de propor uma saída para os problemas ambientais causados pela indústria da construção civil.
Conformity and communal decision-making: First-tester effects on acceptance of home-based HIV counseling and testing in Uganda
Authors: Armstrong-Hough Mari , Meyer Amanda J , Katamba Achilles , Davis J. Lucian 
Published: June 2018

Background: Individuals’ observation of how group members ahead of them behave can profoundly shape their perceptions, judgements, and subsequent behaviors. Moreover, social influence theories from the sociology of networks suggest that individuals’ social status and social network position determine the scope of their influence on other group members. We set out to examine the role of conformity and communal decision-making in shaping individual decisions to test for HIV during home-based TB contact investigation in Kampala, Uganda.
Methods: We analyzed the HIV testing decisions of individuals who were offered free, optional, home-based HIV testing during a home visit by community health workers. We used to generalized estimating equations (GEE) to estimate how the testing decision made by the first individual in a household offered testing influenced the subsequent testing decisions of other household members.
Results: Community health workers visited 55 households with two or more eligible household members and offered 160 individuals HIV testing. Seventy-five (47%) declined the test. Individuals in households where the first person invited declined HIV testing had four times the risk of declining themselves (RR: 3.96, 95% CI: 1.7-9.0, p=0.001) compared to individuals in households where the first person invited agreed to HIV testing, controlling for individual age and gender.
Conclusions: The decision of the first individual offered HIV testing seems to influence the decisions of subsequent household members when they are also offered testing. Even when results are confidential, individual decisions may be shaped by the testing behavior of the first household member offered the test.
Conformity and communal decision-making: First-tester effects on acceptance of home-based HIV counseling and testing in Uganda
Authors: Armstrong-Hough Mari , Meyer Amanda J , Katamba Achilles , Davis J. Lucian 
Published: June 2018

Background: Individuals’ observation of how group members ahead of them behave can profoundly shape their perceptions, judgements, and subsequent behaviors. Moreover, social influence theories from the sociology of networks suggest that individuals’ social status and social network position determine the scope of their influence on other group members. We set out to examine the role of conformity and communal decision-making in shaping individual decisions to test for HIV during home-based TB contact investigation in Kampala, Uganda.
Methods: We analyzed the HIV testing decisions of individuals who were offered free, optional, home-based HIV testing during a home visit by community health workers. We used generalized estimating equations (GEE) to estimate how the testing decision made by the first individual in a household offered testing influenced the subsequent testing decisions of other household members.
Results: Community health workers visited 55 households with two or more eligible household members and offered 160 individuals HIV testing. Seventy-five (47%) declined the test. Individuals in households where the first person invited declined HIV testing had four times the risk of declining themselves (RR: 3.96, 95% CI: 1.7-9.0, p=0.001) compared to individuals in households where the first person invited agreed to HIV testing, controlling for individual age and gender.
Conclusions: The decision of the first individual offered HIV testing seems to influence the decisions of subsequent household members when they are also offered testing. Even when results are confidential, individual decisions may be shaped by the testing behavior of the first household member offered the test.
Distinctive facial features in idiopathic Moyamoya disease in Caucasians: a first systematic analysis
Authors: Kraemer Markus , Huynh Quoc Bao , Wieczorek Dagmar , Balliu Brunilda , Mikat Barbara , Boehringer Stefan 
Published: June 2018

Background
Craniofacial dysmorphic features are morphological changes of the face and skull which are associated with syndromic conditions. Moyamoya angiopathy is a rare cerebral vasculopathy that can be divided into Moyamoya syndrome, which is associated or secondary to other diseases, and into idiopathic Moyamoya disease. Facial dysmorphism has been described in rare genetic syndromes with associated Moyamoya syndrome. However, a direct relationship between idiopathic Moyamoya disease with dysmorphic facial changes is not known yet.

Methods
Landmarks were manually placed on frontal photographs of the face of 45 patients with bilateral Moyamoya disease and 50 matched controls. After procrustes alignment of landmarks a multivariate, penalized logistic regression (elastic-net) was performed on geometric features derived from landmark data to classify patients against controls. Classifiers were visualized in importance plots that colorcode importance of geometric locations for the classification decision.

Results
The classification accuracy for discriminating the total patient group from controls was 82.3% (P-value = 6.3×10−11, binomial test, a-priori chance 50.2%) for an elastic-net classifier. Importance plots show that differences around the eyes and forehead were responsible for the discrimination. Subgroup analysis corrected for body mass index confirmed a similar result.

Discussion
Results suggest that there is a resemblance in faces of Caucasian patients with idiopathic Moyamoya disease and that there is a difference to matched controls. Replication of findings is necessary as it is difficult to control all residual confounding in study designs such as ours. If our results would be replicated in a larger cohort, this would be helpful for pathophysiological interpretation and early detection of the disease.
Mitochondrial diversity of Bulgarian native dogs suggests dual phylogenetic origin
Authors: Marinov Miroslav , Teofanova Denitsa , Gadjev Dimitar , Radoslavov Georgi , Hristov Peter 
Published: June 2018

The dog has been the first domesticated animal to have a central role in human society from ancient times to present day. Although there have been numerous investigations of dog phylogeny and origin, genetic data of dogs in the region of the Balkan Peninsula (South-Eastern Europe) are still scarce. Therefore, the aim of the present study was to perform phylogenetic analysis of three native Bulgarian dog breeds. A total of 130 samples were analyzed at HVR1 (hypervariable region, D-loop region). The samples were taken from two hunting dog breeds (Bulgarian Hound Dog: Barak,n = 34; Bulgarian Scenthound Dog: Gonche,n = 45) as well as from a Bulgarian Shepherd Dog (n = 51). The first two breeds are reared in a flat region of the country (the Northern part of Bulgaria, the Danubian Plain), while the last breed is a typical representative of the mountainous part of the country. The results have shown the presence of almost all main clades—A, B, C and D—in the three dog breeds taken together, except clades E and F, as expected. With regard to haplogroups distribution, there are clear differences among investigated breeds. While hunting breeds exhibit a prevalence of clade C, the mountainous Shepherd dog shows presence of the D2 haplogroup but absence of the C clade. In conclusion, the present study has been the first to investigate the mitochondrial DNA diversity of native dog breeds in Bulgaria. The results have revealed a clear difference of haplogroups dissemination in native hunting and shepherd dogs, which suggests a dual independent phylogenetic origin, without hybridization events between these dogs.
Review of airflow and transport analysis in building using CFD and network model
Authors: Kato Shinsuke 
Published: June 2018

AbstractThis paper reviews computational fluid dynamics (CFD) analysis and simulation of a network model of airflow and transport scenarios, as well as their coupled simulation. The network model is a tool to describe the whole and macroscopic characteristics of airflow transport in buildings, where airflow is modeled as a network of one‐dimensional flow elements. The flow network model can be solved with comparatively less computational cost; however, all the airflows between nodes should be modeled as one‐dimensional. The airflows and their transports in a room are not one‐dimensional but three‐dimensional. CFD is a convenient tool for analyzing such three‐dimensional flows and transports. The equations are non‐linear, and their solutions are usually obtained numerically. The CFD analysis requires considerable computation resources and computational time. To analyze the whole and macroscopic characteristics of airflows and their transports in buildings including the space distribution features in a certain room, the two simulations should be carried out simultaneously. In this work, the author reviews the conduction of CFD in a room, network simulation in a whole building, and simulation of their coupling. Further, the author's previous works pertaining to this subject are explained.
Actinide Borohydrides
Authors: Daly Scott R. 
Published: June 2018

AbstractActinide borohydrides, first discovered during the Manhattan Project, are broadly defined as complexes that form B–H–M bonds, where M is a 5f metal. The earliest examples were discovered during the search for volatile uranium complexes to separate fissile U‐235 for atomic weapons. After World War II, it was reported that simple borohydride complexes such as U(BH4)4, U(BH4)3(BH3Me), and U(BH3Me)4were extremely volatile, setting into motion efforts to discover new actinide borohydride complexes and understand their exceptional properties. In this article, we provide a comprehensive review of the synthesis, properties, and structures of actinide complexes bearing the most common types of borohydride ligands, namely tetrahydroborates (BH4−), methyltrihydroborates (BH3Me−), and their Lewis base adducts. Thorium and uranium complexes containing the chelating borohydride ligandN,N‐dimethylaminodiboranate (H3BNMe2BH3−) and less‐common hydroborate, dihydroborate, and trihydroborate complexes of the actinides are also discussed.
Supramolecular and Macrocyclic Chemistry of the Actinides
Authors: Mei Lei , Lan Jianhui , Hu Kongqiu , Shi Weiqun 
Published: June 2018

AbstractSupramolecular chemistry is the field of chemistry beyond molecules, and mainly focuses on systems made up of a number of discrete molecular subunits or components assembled through noncovalent forces such as electrostatic and hydrophobic interactions, hydrogen bonding, halogen bonds, andπ–πinteractions. Supramolecular chemistry deals with issues related to self‐assembly processes, a major issue in actinide‐related supramolecular chemistry. Metal–ligand coordination in which the bonds are of moderate bonding strength is essentially also one of the noncovalent interactions that are suitable for constructing supramolecular systems. Similar to transition metal and lanthanide‐based systems, there are many kinds of supramolecular assembly architectures actinide polyrotaxanes, actinide‐coordination‐driven closed or circular architectures as well as supramolecular systems involving weak interactions based on actinide–ligand interactions. In the field of supramolecular chemistry, macrocyclic compounds take up quite a large portion of research concerning with self‐assembly and metal coordination. The excellent complexation capacity of these macrocyclic compounds has made them promising candidates for the construction of actinide‐macrocyclic assemblies and the extraction and separation of actinides.
Laser‐Based Spectroscopic Studies of Actinide Complexes
Authors: Jung Euo Chang , Cho Hye‐Ryun , Kim Hee‐Kyung , Cha Wansik 
Published: June 2018

AbstractThe purpose of this article is to introduce laser spectroscopic studies for the chemical speciation of actinide complexes to those who are interested in the highly sensitive analytical techniques used in the nuclear industry. The chemical speciation of actinide complexes is considered to be a key concept for the safe management of spent nuclear fuels in the back‐end of a nuclear fuel cycle. Time‐resolved laser fluorescence spectroscopy (TRLFS) and laser‐induced photoacoustic spectroscopy (LPAS) are accepted as very effective techniques to analyze trace amounts of actinide complexes in aqueous solutions. In the present case study, TRLFS and LPAS are primarily used for the chemical speciation of U(VI)‐ and Pu(VI)‐hydroxo complexes, respectively. For the practical application of TRLFS, the chemical speciation of trace amounts of Ca–U(VI)‐carbonate species dissolved in groundwater is described. A spectrophotometry coupled with a liquid waveguide capillary cell is applied for the chemical speciation of U(IV)‐hydroxo complex as an alternative technique to LPAS. The absorption and luminescence characteristics of Am(III) species are also described.
Actinides in Medicine
Authors: Birnbaum Eva R. , Fassbender Michael E. , Ferrier Maryline G. , John Kevin D. , Mastren Tara 
Published: June 2018

AbstractA summary of actinides and their past, present, and future applications in medicine is provided herein. Details associated with the role that actinides play in medical imaging and therapy is captured along with modes of production, medically relevant decay chains, principles of chelation, and target vectoring. Summaries of preclinical and clinical studies with specific emphasis on the field of targetedαtherapy are also provided for Ac‐225, Th‐227, U‐230, Th‐226, and Bi‐213 (daughter of Ac‐225).
Actinide Elements in Catalysis
Authors: Batrice Rami J. , Karmel Isabell S.R. , Yardeni Guy , Eisen Moris S. 
Published: June 2018

AbstractThe chemistry of the f‐elements has been marked in recent years by the impressive use of actinides in catalysis. These advances have allowed the actinide community to tailor organoactinide complexes for specific reactivities accomplishing a high level of sophistication. It is important to note that when comparing the actinides to transition or lanthanide block complexes, the actinides will sometimes exhibit complementary reactivities; however, most often, distinctive chemistries are displayed for similar organic transformations. Based on their unique electronic and steric characteristics, it is now possible to design new catalytic transformations. This article highlights the catalytic processes including the activation of small molecules, hydroelementations, coupling reactions, and polymerization/oligomerization of cyclic esters and epoxides.
Deoxyhypusine Hydroxylase
Authors: Lindae Antje , Han Zhenggang , Hilgenfeld Rolf 
Published: June 2018

AbstractDeoxyhypusine hydroxylase (DOHH) is a monomeric monooxygenase that catalyzes a critical reaction step of the unique protein modification called hypusination. Modified at a specific lysine residue, eukaryotic translation initiation factor 5a (eIF‐5A) is the only protein known to be hypusinated. The presence of the noncanonical amino acid hypusine in eIF‐5A is not only crucial for the activity of the protein and vital for eukaryotic cells, but is also involved in the pathogenesis of several diseases, such as cancer, AIDS, and diabetes. DOHH is therefore considered a novel target for the design of drugs against these major health threats. DOHH is a nonheme diiron enzyme that activates oxygen for substrate hydroxylation. Featuring a blue chromophore, the peroxo‐diiron(III) intermediate of human DOHH is unusually stable, allowing its crystallization and the first elucidation of a three‐dimensional structure of this intermediate in its native biological environment. The overall structure of DOHH comprises two pseudosymmetric domains, each consisting of four HEAT repeats. The structural information, in combination with spectroscopic analyses and comparison to other nonheme diiron enzymes, has been used to suggest a putative catalytic mechanism for DOHH. Compounds shown to inactivate DOHH include ciclopirox, mimosine, deferiprone, and zileuton.
Formyl‐Methanofuran Dehydrogenase
Authors: Wagner Tristan , Ermler Ulrich , Shima Seigo 
Published: June 2018

AbstractFormyl‐methanofuran dehydrogenase reversibly catalyzes under anoxic conditions the reductive fixation of CO2onto the one‐carbon carrier methanofuran (MFR) forming formyl‐MFR according to the equation: CO2+ MFR + 2[H] ⇌ CHO‐MFR + H2O. The soluble multisubunit formyl‐MFR dehydrogenase complex is basically built up of an Mo/W‐bis pyranopterin guanosine dinucleotide (Mo/W‐pterin) containing formate‐dehydrogenase unit catalyzing the CO2reduction to formate and a dinuclear Zn2+containing amidohydrolase unit catalyzing the condensation of formate with MFR. In many family members, electron‐supply units as (poly)ferredoxin domains carrying iron–sulfur clusters are associated with the two catalytic units. Mo‐ and W‐pterin‐dependent enzymes occur as two distinct isoenzymes abbreviated as Fmd and Fwd, respectively.
tRNAModification by Elongator Protein 3 (Elp3)
Authors: Lin Ting‐Yu , Glatt Sebastian 
Published: June 2018

AbstractElongator 3 (Elp3) represents the enzymatically active subunit of the multisubunit Elongator complex that catalyzes the first step of the 5‐methoxycarbonylmethyl and 5‐carbamoylmethyl modification reaction at uridine bases in the wobble position of tRNAs. These modifications are essential for accurate protein translation rates and proteome homeostasis, and their loss is detrimental, leading to cellular dysfunctions, neurodegenerative diseases, and cancers. The electron microscopy structure of the Elongator and the crystal structure of Elp3 have recently been resolved, but details of the enzymatic reaction still remain elusive. One copy of Elp3 is located in each center of the two Elp123 lobes, and unlike other known modifying enzymes, Elp3 consists of two functional domains, namely radicalS‐adenosyl methionine and lysine acetyltransferase domains. The SAM domain harbors an iron–sulfur (Fe–S) cluster, which is essential for the integrity and activity of the complex. In addition, Elp3 coordinates zinc and interacts with Kti11, a regulatory factor that coordinates iron and zinc, most likely acting as an electron donor for the respective Fe–S cluster of Elp3. Through the unique combination and interplay of its two domains, Elp3 is able to cleave SAM, generate necessary deoxy radicals, and transfer an acetyl radical from acetyl‐CoA to C5 of U34.