bluuebunny/crossref_metadata_2025_split huggingface dataset:
Considerations for the Use of Neuroimaging Technologies for Predicting Recovery of Speech and Language in Aphasia
Authors: Shuster Linda I. 
Published: March 2018

PurposeThe number of research articles aimed at identifying neuroimaging biomarkers for predicting recovery from aphasia continues to grow. Although the clinical use of these biomarkers to determine prognosis has been proposed, there has been little discussion of how this would be accomplished. This is an important issue because the best translational science occurs when translation is considered early in the research process. The purpose of this clinical focus article is to present a framework to guide the discussion of how neuroimaging biomarkers for recovery from aphasia could be implemented clinically.MethodThe genomics literature reveals that implementing genetic testing in the real-world poses both opportunities and challenges. There is much similarity between these opportunities and challenges and those related to implementing neuroimaging testing to predict recovery in aphasia. Therefore, the Center for Disease Control's model list of questions aimed at guiding the review of genetic testing has been adapted to guide the discussion of using neuroimaging biomarkers as predictors of recovery in aphasia.ConclusionThe adapted model list presented here is a first and useful step toward initiating a discussion of how neuroimaging biomarkers of recovery could be employed clinically to provide improved quality of care for individuals with aphasia.
Dual‐resonance‐based wideband antenna for integrated module applications
Authors: Qu Longyue , Piao Haiyan , Qu Yunhao , Kim Hyung‐Hoon , Kim Hyeongdong 
Published: March 2018

A wideband module antenna comprised of a small ground radiation antenna in the module and a parasitic radiation loop in the evaluation board is proposed. Unlike conventional ground radiation antennas, the ground radiation antenna in the module works as an exciter to the parasitic radiation loop, which further couples with the evaluation board as a radiator. Thus, a space‐saving antenna is obtained with wide bandwidth and easy tuning. Accordingly, dual resonance can be generated by tuning the resonant frequencies of the ground radiation antenna and the parasitic radiation loop equally. When measured, the antennas have wide bandwidths (2:1 voltage standing wave ratio bandwidth of 270 MHz) and high efficiency (ranging from 44 to 74%).
High redshift galaxies in the ALHAMBRA survey
Authors: Viironen K. , López-Sanjuan C. , Hernández-Monteagudo C. , Chaves-Montero J. , Ascaso B. , Bonoli S. , Cristóbal-Hornillos D. , Díaz-García L. A. , Fernández-Soto A. , Márquez I. , Masegosa J. , Pović M. , Varela J. , Cenarro A. J. , Aguerri J. A. L. , Alfaro E. , Aparicio-Villegas T. , Benítez N. , Broadhurst T. , Cabrera-Caño J. , Castander F. J. , Cepa J. , Cerviño M. , González Delgado R. M. , Husillos C. , Infante L. , Martínez V. J. , Moles M. , Molino A. , del Olmo A. , Perea J. , Prada F. , Quintana J. M. 
Published: March 2018

Context.Knowing the exact shape of the ultraviolet (UV) luminosity function (LF) of high-redshift galaxies is important to understand the star formation history of the early Universe. However, the uncertainties, especially at the faint and bright ends of the LFs, remain significant.Aims.In this paper, we study the UV LF of redshiftz =2.5 – 4.5 galaxies in 2.38 deg2of ALHAMBRA data withI≤ 24. Thanks to the large area covered by ALHAMBRA, we particularly constrain the bright end of the LF. We also calculate the cosmic variance and the corresponding bias values for our sample and derive their host dark matter halo masses.Methods.We have used a novel methodology based on redshift and magnitude probability distribution functions (PDFs). This methodology robustly takes into account the uncertainties due to redshift and magnitude errors, shot noise, and cosmic variance, and models the LF in two dimensions (z,MUV).Results.We find an excess of bright *M*UVgalaxies as compared to the studies based on broad-band photometric data. However, our results agree well with the LF of the magnitude-selected spectroscopic VVDS data. We measure high bias values,b ~8 – 10, that are compatible with the previous measurements considering the redshifts and magnitudes of our galaxies and further reinforce the real high-redshift nature of our bright galaxies.Conclusions.We call into question the shape of the LF at its bright end; is it a double power-law as suggested by the recent broad-band photometric studies or rather a brighter Schechter function, as suggested by our multi-filter analysis and the spectroscopic VVDS data.
Reactivity in interstellar ice analogs: role of the structural evolution
Authors: Ghesquière P. , Ivlev A. , Noble J. A. , Theulé P. 
Published: March 2018

Context. The synthesis of interstellar complex organic molecules in ice involves several types of reactions between molecules and/or radicals that are usually considered to be diffusion controlled.
Aims. We aim to understand the coupling between diffusion and reactivity in the interstellar ice mantle using a model binary reaction in the diffusion-limited regime.
Methods. We performed isothermal kinetic laboratory experiments on interstellar ice analogs at low temperatures, using the NH3:CO2:H2O model system where reactants NH3 and CO2 have a low reaction barrier and are diluted in a water-dominated ice.
Results. We found that in the diffusion-limited regime, the reaction kinetics is not determined by the intrinsic bulk diffusivity of reactants. Instead, reactions are driven by structural changes evolving in amorphous water ice, such as pore collapse and crystallization. Diffusion of reactants in this case likely occurs along the surface of (tiny) cracks generated by the structural changes.
Conclusions. The reactivity driven by the structural changes breaks the conventional picture of reactant molecules/radicals diffusing in a bulk water ice. This phenomenon is expected to lead to a dramatic increase in production rates of interstellar complex organic molecules in star-forming regions.
Eingeschränkte Schlafqualität als indirekte psychosoziale Folge einer
Fazialisparese
Authors: Worrack Susanne , Guntinas-Lichius Orlando , Volk Gerd Fabian , Kaczmarek Magdalena C. , Mühleck Julia , Brenk-Franz Katja , Strauß Bernhard M. , Altmann Uwe 
Published: March 2018

Zusammenfassung
Hintergrund Fazialisparese (FP) ist eine Lähmung der Gesichtsmuskulatur und zählt zu den häufigsten
motorischen Ausfällen. Sie geht mit einer starken Beeinträchtigung der Lebensqualität und depressiven
Symptomen einher. Schlafstörungen in Folge einer FP werden oft auf krankheitsbedingte Beeinträchtigungen
zurückgeführt, obwohl auch psychosoziale Belastungen als Ursache in Frage kämen. Diese Studie untersuchte
direkte und indirekte Effekte der FP auf die Schlafqualität.
Methoden Die Stichprobe der Querschnittsstudie umfasste N = 81 FP-Patienten. Es wurden Symptome der
Gesichtsnervenlähmung (FACE), Schlafqualität (PSQI), Lebensqualität (SF36), Depressivität (PHQ9), soziale
Ängste (LSAS) und soziodemographische Daten erfasst. Mit Mediationsmodellen wurden Zusammenhänge zwischen
Symptomen der FP, sozialen Ängsten, Depressivität und Schlafqualität untersucht.
Ergebnisse Die Schlafqualität war bei 33,3 % der Patienten verringert. Die subjektiv eingeschätzte
Schwere der FP korrelierte mit der Schlafqualität. Mediationsanalysen legen eine Kausalkette zwischen der
Schwere der FP, sozialen Ängsten, depressiven Symptomen und einer eingeschränkten Schlafqualität nahe. Wurden
soziale Ängste und Depressivität als Mediatoren in das Modell aufgenommen, gab es keine direkten Effekte der
FP auf die Schlafqualität.
Schlussfolgerung Schlafprobleme im Kontext einer FP scheinen weniger durch die krankheitsbedingten
Beeinträchtigung verursacht, als vielmehr eine indirekte Folge: Die mit einer FP eingehergehende Veränderung
des Gesichtes verursacht psychische Beschwerden welche wiederum zu verminderter Schlafqualität führen. Die
medizinische Versorgung von FP-Patienten sollte deshalb auch die psychosozialen Folgen in den Blick nehmen, um
der Entstehung psychischer Störungen (z. B. Depressionen) und Schlafstörungen vorzubeugen.
Dosimetrie bei der Selektiven Internen Radiotherapie (SIRT)
Authors: Großer Oliver , Genseke Philipp , Kreißl Michael 
Published: March 2018

ZusammenfassungFür die Berechnung der Therapieaktivität im Rahmen der Selektiven Internen Radiotherapie (SIRT oder auch Radioembolisation) existieren unterschiedlich elaborierte Berechnungsmodelle. Diese besitzen empirischen Charakter bzw. basieren auf makroskopischen Ansätzen unter der Annahme einer Gleichverteilung der Mikrosphären und damit der akkumulierten Dosis (MIRD-basierter Modellansatz). Eine Inhomogenität in der Anreicherung des Radioembolisats, welche regulär durch die post-therapeutische Bildgebung beobachtet wird, findet in den Dosierungskonzepten keine Berücksichtigung. Für die weitere Entwicklung wäre es hier wünschenswert, radiobiologische Konzepte stärker zu integrieren und eine Dosierung der Therapieaktivität unter Berücksichtigung der (limitierenden) gewebsspezifischen Toleranzen durchzuführen.Generell sind die Bewertung der Effektivität und der Nebenwirkungen sowie die damit verbundene Definition von Toleranzdosen/Zieldosen schwierig. Die verfügbaren Daten weisen aufgrund der Heterogenität der untersuchten Endpunkte, unterschiedlicher basaler Leberfunktion und individueller Erkrankungshistorien (Vortherapie) eine große Streuung und eine damit verbundene große Unsicherheit auf.
Dosimetrie bei der Radionuklidtherapie mit Lu-177
Authors: Gosewisch Astrid , Ilhan Harun , Vomacka Lena , Böning Guido 
Published: March 2018

ZusammenfassungDie Radioligandentherapie (RLT) mit radioaktiv markierten PSMA-Liganden (z. B. Lu-177-PSMA-617) und die Peptid-Rezeptor-Radionuklidtherapie (PRRT) mit radioaktiv markierten Somatostatin-Analoga (z. B. Lu-177-DOTATATE) haben sich über die letzten Jahre als vielversprechende Therapieoptionen bei metastasierten, kastrationsresistenten Prostatakarzinomen bzw. inoperablen oder metastasierten neuroendokrinen Tumoren entwickelt. Das Theragnostiknuklid Lu-177 weist dabei neben der Therapie-relevanten Beta-Minus-Komponente eine, auch für die Bildgebung gut nutzbare, Gammaemission auf, die eine direkte quantitative Bildgebung und Dosimetrie der Radiopharmakonverteilung möglich macht. Die Patienten-spezifische 3D-Dosimetrie auf Basis der quantitativen Lu-177-Bildgebung ist dabei der Schlüssel hin zur individualisierten Therapiekontrolle und -planung in der RLT und PRRT, in denen bisher vornehmlich noch standardisierte Aktivitätsmengen verabreicht werden. Jedoch ist die Ermittlung robuster Dosiswerte klinisch aufwändig, sowohl bez. des Messaufwands als auch hinsichtlich der Auswertung der Daten, und die starke Variabilität der Dosiswerte und deren Abhängigkeit von der verwendeten Methodik erschweren die Etablierung Therapie-spezifischer Dosis-Wirkungsbeziehungen. Gerade der Vergleich von Dosimetriedaten zwischen den Kliniken erfordert eine systematische und vereinheitlichte Dosimetrie mit akzeptablem klinischem Aufwand. Die Genauigkeit der Dosimetrie ist derzeit v. a. limitiert durch Effekte der Bildgebung. Zusätzliche Fehler können sich bspw. durch eine ungünstige Wahl der gemessenen Datenpunkte, Bewegungsartefakte, Überlagerungseffekte in der planaren Bildgebung oder durch eine nicht vollständig klinisch durchführbare Definition der Zielregion (z. B. Knochenmark) ergeben. Die 3D-Dosimetrie, unter Berücksichtigung zusätzlicher physikalischer oder biologischer Parameter (z. B. Dosisrate), kann in der Radionuklidtherapie einen wichtigen Beitrag zur Etablierung von Dosis-Wirkungsbeziehungen liefern, allerdings ist die klinisch-physiologische Interpretation der 3D-Dosisverteilungen derzeit noch stark limitiert durch Bildartefakte und Bildrauschen in den zur Dosimetrie eingesetzten SPECT-Bildern.
Down-regulation of senescence marker protein 30 by iron-specific chelator deferoxamine drives cell senescence
Authors: Inoue Hirofumi , Hanawa Nobuaki , Katsumata-Tsuboi Rie , Katsumata Shi-Ichi , Takahashi Nobuyuki , Uehara Mariko 
Published: March 2018

Abstract
To our knowledge, this is the first study to report down-regulation of senescence marker protein 30 (SMP30) by iron-specific chelator deferoxamine (DFO) on FAO cell senescence, using a DNA microarray. Furthermore, DFO treatment increased senescence marker β-galactosidase activity, whereas this activity was attenuated by overexpression of SMP30. Our data suggested that down-regulation of SMP30 drives cell senescence in iron-chelated condition.
Translation and language errors in the Indonesian–English translation
Authors: Dewi Haru Deliana 
Published: March 2018

ABSTRACT
This paper is a small part of my dissertation which particularly describes translation and language errors based on trends in Translation Studies. Translation and language errors are important to assess the quality of a translation product. However, little or almost none of the literature has discussed the translation and language errors in the Indonesian–English language pair. This study aims to discover the types of translation and language errors mostly found in the Indonesian–English translation. The data were obtained by conducting several projects in the translation classes of LBI (Lembaga Bahasa International – International Language Institution) of the Faculty of Humanities (FIB) of Universitas Indonesia (UI) for 2 years from 2013 to 2015 by asking the students to do translation from an Indonesian text into English. The results show that the most frequent errors occurring are incorrect usage, grammatical errors, and omissions. This paper can be considered as preliminary research on translation and language errors in the Indonesian–English language pair which should be further investigated.
Theoretical implications of the galactic radial acceleration relation of McGaugh, Lelli, and Schombert
Authors: Nesbet Robert K 
Published: March 2018

Abstract
Velocities in stable circular orbits about galaxies, a measure of centripetal gravitation, exceed the expected Kepler/Newton velocity as orbital radius increases. Standard Λ cold dark matter (ΛCDM) attributes this anomaly to galactic dark matter. McGaugh et al. have recently shown for 153 disc galaxies that observed radial acceleration is an apparently universal function of classical acceleration computed for observed galactic baryonic mass density. This is consistent with the empirical modified Newtonian dynamics (MOND) model, not requiring dark matter. It is shown here that suitably constrained ΛCDM and conformal gravity (CG) also produce such a universal correlation function. ΛCDM requires a very specific dark matter distribution, while the implied CG non-classical acceleration must be independent of galactic mass. All three constrained radial acceleration functions agree with the empirical baryonic v4 Tully–Fisher relation. Accurate rotation data in the nominally flat velocity range could distinguish between MOND, ΛCDM, and CG.
The Influence of Hearing Aid Gain on Gap-Detection Thresholds for Children and Adults With Hearing Loss
Authors: Brennan Marc A. , McCreery Ryan W. , Buss Emily , Jesteadt Walt 
Published: March 2018

Objectives:
The objective of this experiment was to examine the contributions of audibility to the ability to perceive a gap in noise for children and adults. Sensorineural hearing loss (SNHL) in adulthood is associated with a deficit in gap detection. It is well known that reduced audibility in adult listeners with SNHL contributes to this deficit; however, it is unclear the extent to which hearing aid amplification can restore gap-detection thresholds, and the effect of childhood SNHL on gap-detection thresholds have not been described. For adults, it was hypothesized that restoring the dynamic range of hearing for listeners with SNHL would lead to approximately normal gap-detection thresholds. Children with normal hearing (NH) exhibit poorer gap-detection thresholds than adults. Because of their hearing loss, children with SNHL have less auditory experience than their peers with NH. Yet, it is unknown the extent to which auditory experience impacts their ability to perceive gaps in noise. Even with the provision of amplification, it was hypothesized that children with SNHL would show a deficit in gap detection, relative to their peers with normal hearing, because of reduced auditory experience.

Design:
The ability to detect a silent interval in noise was tested by adapting the stimulus level required for detection of gap durations between 3 and 20 ms for adults and children with and without SNHL. Stimulus-level thresholds were measured for participants with SNHL without amplification and with two prescriptive procedures—the adult and child versions of the desired sensation level i/o program—using a hearing aid simulator. The child version better restored the normal dynamic range than the adult version. Adults and children with NH were tested without amplification.

Results:
When fitted using the procedure that best restored the dynamic range, adults with SNHL had stimulus-level thresholds similar to those of adults with normal hearing. Compared to the children with NH, the children with SNHL required a higher stimulus level to detect a 5-ms gap, despite having used the procedure that better restored the normal dynamic range of hearing. Otherwise, the two groups of children had similar stimulus-level thresholds.

Conclusion:
These findings suggest that apparent deficits in temporal resolution, as measured using stimulus-level thresholds for the detection of gaps, are dependent on age and audibility. These novel results indicate that childhood SNHL may impair temporal resolution as measured by stimulus-level thresholds for the detection of a gap in noise. This work has implications for understanding the effects of amplification on the ability to perceive temporal cues in speech.
Effects of Clonidine on the Cardiovascular, Renal, and Inflammatory Responses to Experimental Bacteremia
Authors: Calzavacca Paolo , Booth Lindsea C. , Lankadeva Yugeesh R. , Bailey Simon R. , Burrell Louise M. , Bailey Michael , Bellomo Rinaldo , May Clive N. 
Published: March 2018

ABSTRACT

Introduction:
Supra-clinical doses of clonidine appear beneficial in experimental sepsis, but there is limited understanding of the effects of clonidine at clinically relevant doses.

Methods:
In conscious sheep, with implanted renal and pulmonary artery flow probes, sepsis was induced by infusion of live Escherichia coli. At 24 h, a high clinical dose of clonidine (HCDC) [1.0 μg/kg/h], a low clinical dose of clonidine (LCDC) [0.25 μg/kg/h] or vehicle, was infused for 8 h.

Results:
Animals developed hyperdynamic, hypotensive sepsis with acute kidney injury. The HCDC decreased heart rate (153 ± 6 to 119 ± 7 bpm) and cardiac output (5.6 ± 0.4 to 5.0 ± 0.4 L/min), with no reduction in mean arterial pressure (MAP). In contrast, LCDC increased cardiac output with peripheral vasodilatation. Both doses induced a large transient increase in urine output, an increase in plasma osmolality and, with the high dose, an increase in plasma arginine vasopressin. Sepsis increased plasma interleukin-6 (IL-6) and IL-10 and clonidine further increased IL-10 (1.6 ± 0.1 to 3.3 ± 0.7 ng/mL), but not IL-6. Clonidine reduced rectal temperature. During recovery from sepsis, MAP returned to baseline values more rapidly in the HCDC group (P < 0.001).

Conclusions:
In hyperdynamic, hypotensive sepsis, the effects of clonidine at clinically relevant doses are complex and dose dependent. HCDC attenuated sepsis-related increases in heart rate and cardiac output, with little effect on arterial pressure. It also induced a water diuresis, increased AVP, reduced body temperature, and had an anti-inflammatory action. Low-dose clonidine had similar but less pronounced effects, except that it induced moderate vasodilatation and increased cardiac output.
Sexual Satisfaction Changes Reported by Men After Their Partners' Robotic-Assisted Laparoscopic Sacrocolpopexies
Authors: Culligan Patrick J. , Haughey Sean , Lewis Christa , Priestley Jennifer , Salamon Charbel 
Published: March 2018

Objectives
This study aimed to compare the preoperative and postoperative sexual satisfaction reported by male sexual partners of women undergoing surgical correction of pelvic organ prolapse.

Methods
This was a single-center prospective cohort study. Heterosexual, sexually active English-speaking couples in which the women were planning to undergo robotic-assisted laparoscopic sacrocolpopexy for correction of pelvic organ prolapse were eligible for enrollment in the study. Validated sexual function questionnaires—the Sexual Experience Questionnaire (SEX-Q; Mulhall et al. J Sex Med. 2008) and Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire-12 (Rogers, et al. Int Urogynecol J Pelvic Floor Dysfunct. 2003)—were used to evaluate preoperative and postoperative male and female sexual experience, respectively. These preoperative scores were compared using paired t tests. The Student t and the Mann-Whitney tests were used to compare study-eligible couples with noneligible couples and to compare study participants with nonparticipants.

Results
During the study enrollment period, 92 couples met the inclusion criteria and 45 of those were enrolled. Complete data sets of preoperative and postoperative questionnaires were obtained for 36 couples. After their partners' successful reconstructive surgery, male study subjects reported improved total SEX-Q scores (mean ± SD, 71 ± 16.7 vs 76.5 ± 17.8; P = 0.025). Within the subscales of the SEX-Q, there was significant improvement between preoperative and postoperative “individual satisfaction” scores (mean ± SD, 65.7 ± 16.8 vs 78.9 ± 17.5; P < 0.0001), but not within the “erectile dysfunction” or “couple satisfaction” subscales. Female partners reported improved Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire-12 scores after surgery (mean ± SD, 36.6 ± 5.5 vs 40.0 ± 4.6; P = 0.003).

Conclusions
Sexually active heterosexual men and women reported improved sexual experience after successful prolapse repair.