bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct effects of daratumumab on indirect and direct antiglobulin tests: a new method employing 0.01 mol/L dithiothreitol for negating the daratumumab interference with preserving K antigenicity (Osaka method)
Authors: Hosokawa Mika , Kashiwagi Hirokazu , Nakayama Kotarosumitomo , Sakuragi Mikiko , Nakao Mayumi , Morikawa Tamayo , Kiyokawa Tomoko , Aochi Hiroshi , Nagamine Keisuke , Shibayama Hirohiko , Tomiyama Yoshiaki 
Published: September 2018

BACKGROUNDThere is an increasing demand for daratumumab (DARA), an immunoglobulin (Ig)G1κ monoclonal antibody (MoAb) that recognizes CD38, to manage relapsed or refractory multiple myeloma (MM) patients. However, DARA leads to positive and panreactive agglutination reactions in indirect antiglobulin tests (IATs) in vitro (the DARA interference). In addition, effects of DARA on red blood cells (RBCs) in vivo remains elusive.STUDY DESIGN AND METHODSTo develop a new method to negate the DARA interference, the effects of various concentrations of dithiothreitol (DTT) on RBC CD38 and Kell antigenicity in combination with an automatic blood cell washing centrifuge were compared with the AABB standard procedure in parallel. Moreover, direct antiglobulin tests (DATs) for RBCs in DARA‐treated MM patients were examined.RESULTSA quantity of 0.01 mol/L DTT as well as the AABB procedure (equivalent to 0.15 mol/L DTT in our procedure) markedly reduced the reactivity of phycoerythrin‐mouse anti‐CD38 MoAb and DARA with RBCs. In sharp contrast to the AABB procedure, 0.01 mol/L DTT partially preserved K antigenicity and allowed the determination of phenotype of K antigen even in the presence of the DARA interference. In contrast, DAT for RBCs obtained from MM patients showed a weak positive or negative reaction. Immunoblotting further indicated that DARA induced loss of CD38 in vivo.CONCLUSIONA simple and reliable method to negate the DARA interference with partially preserving Kell antigenicity is proposed (Osaka method). CD38 antigenicity is susceptible to 0.01 mol/L DTT treatment even in the presence of DARA. Our data also demonstrate distinct effects of DARA on IAT in vitro and DAT in vivo.
Platelet storage in more than 90% additive solution containing glucose and bicarbonate has the potential to increase shelf life
Authors: Bashir Saber , Kemsley Kelly , Min Kyungyoon , Swann Ian D. , Cardigan Rebecca 
Published: September 2018

BACKGROUNDPlatelet concentrates (PCs) suspended in more than 90% additive solution (AS) are recommended for patients with reactions to platelets stored in plasma. Next‐generation AS containing glucose and bicarbonate might enable storage of these PCs for longer than those in current‐generation AS, which was therefore evaluated in this study.STUDY DESIGN AND METHODSFive buffy coat or apheresis‐derived PCs were pooled and split into identical units. All units except the control were centrifuged, the plasma removed and replaced with AS (SSP+, PAS‐5, or PAS‐G), or resuspended in the same plasma and sampled 96 hours after resuspension for analysis.RESULTSPlasma carryover was less than 10%, total protein less than 1 g/unit, and immunoglobulin A levels lower than 0.1 mg/mL for all PCs in AS. The pH of all the platelets during storage was higher than 6.4. PAS containing glucose maintained superior in vitro platelet function during storage compared with those resuspended in SSP+. Compared with storage in SSP+, storage in PAS‐5 or PAS‐G resulted in better preservation of platelet adenosine triphosphate and hypotonic shock response, lower annexin V binding, and improved mitochondrial membrane potential.CONCLUSIONPlatelets resuspended in PAS‐5 and PAS‐G maintained in vitro function and metabolism during storage compared with SSP+ platelets. Elevated platelet metabolic activity was noticed in PAS‐G, and higher platelet activation was detected with PAS‐5. Platelets resuspended in PAS containing glucose has the potential to increase the shelf life of PC in more than 90% AS.
Management of total hip replacement luxation with triple pelvic osteotomy
Authors: Monotti Isobel C. , Ryan Stewart D. , Preston Chris A. 
Published: September 2018

AbstractObjectiveTo report the outcome of dogs treated with triple pelvic osteotomy (TPO) for dorsal luxation after total hip replacement (THR).Study designRetrospective clinical case series.AnimalsSeventeen client‐owned animals.MethodsMedical records were searched at a single institution for dogs that had been treated with TPO for dorsal THR luxation. The angle of lateral opening (ALO), version angle (VA), and inclination angle (IA) were measured from radiographs after THR and TPO and corrected for pelvic rotation. A pairedttest was performed to compare cup orientation after THR and TPO. Functional outcome was assessed at follow‐up examination and during telephone interviews.ResultsEighteen TPOs were performed in 17 dogs, and radiographs were available for 15 cases. Open and/or closed hip reduction with additional stabilization was attempted unsuccessfully in 6 dogs prior to TPO. Triple pelvic osteotomy reduced the ALO by a mean of 23.0 ° ± 10.9 ° (P ≤ .001), increased VA by 9.0 ° ± 4.9 ° (P < .001), and increased IA by 2.9 ° ± 5.8 ° (P = .126). An excellent or good outcome was achieved in 12 dogs. Ventral luxation occurred in 3 dogs, and dorsal luxation occurred in 1 dog after TPO. Triple pelvic osteotomy excessively reduced ALO in 2 dogs with ventral luxation.ConclusionTriple pelvic osteotomy with cup retention is a viable alternative to cup revision for treatment of dorsal luxation of cemented and cementless THR. Triple pelvic osteotomy significantly reduces ALO and increases VA. Careful patient selection is recommended because excessive ventroversion can lead to ventral luxation.Clinical significanceTriple pelvic osteotomy offers a revision option that preserves the implant–bone interface and significantly reduces ALO. This technique may be appropriate in dogs with high ALO, luxoid hips, and prior failed revision attempts.
Radical cystectomy and subsequent ureterohysterostomy in a bitch
Authors: Delaune Tiare , Bernard Fabrice , Matres‐Lorenzo Luis , Bernardé Antoine 
Published: September 2018

AbstractObjectiveTo describe and report the outcome of a ureterouterine anastomosis after unilateral dehiscence of a ureterovaginal anastomosis after total cystectomy in a bitch.Study designCase report.AnimalA 10‐year‐old intact female border collie with a urinary bladder leiomyosarcoma.MethodsThe dog was diagnosed with an invasive urinary bladder tumor, treated by radical cystectomy and bilateral ureterovaginal anastomosis. Postoperative necrosis of the distal ureter led to dehiscence of the anastomosis on the right side. To preserve the right kidney, the right ureter was anastomosed to the right uterine horn, and a stent was placed across the uterine cervix.ResultsThe dog recovered from surgery and regained satisfactory urine output. Both ureteral anastomoses were patent at 10 months postoperatively. At 12 months postoperatively, intraluminal obstruction of the uterine stent, loss of patency of the right ureter, and severe right renal hydronephrosis were noted. The owner declined nephrectomy, and the dog died 2 months later.ConclusionThis is the first published report of a ureterouterine anastomosis and stenting of the uterine cervix in a dog. The functional outcome was satisfactory for 1 year postoperatively. The uterine stent and distal ureter were eventually obstructed by soft tissue.Clinical significanceUreterouterine anastomosis can be considered as a salvage procedure when other surgical techniques have failed.
Teaching and proficiency assessment for arthroscopy in veterinary surgery: A 2017 survey of diplomates and residents of the American and European College of Veterinary Surgeons
Authors: Maurin Marie‐Pauline , Pozzi Antonio , Bleedorn Jason , McNally Turlough P. , Cuddy Laura C. 
Published: September 2018

AbstractObjectiveTo determine current methods of arthroscopic skills training and proficiency assessment, identify skills considered fundamental to arthroscopy, and evaluate desire for a formal training and assessment program.Study designAnonymized electronic survey.Sample populationDiplomates and residents of the American College of Veterinary Surgeons (ACVS) and European College of Veterinary Surgeons (ECVS).MethodsAn electronic survey was distributed in commercial software (Qualtrics, Provo, Utah). Questions were divided into 4 categories: (1) demographics, (2) arthroscopy experience, (3) teaching, and (4) proficiency assessment. Descriptive statistical analysis was performed. Comparisons between groups were performed by using χ2,ttests, and 1‐way ANOVA (P ≤ .05).ResultsIn total, 429 diplomates and 149 residents responded (response rate 28%). Overall, 80% of respondents trained using clinical cases. Barriers to simulator training included cadaver/simulator availability and time. Skills deemed most fundamental included anatomic knowledge, precise portal placement, triangulation, and image orientation. Overall, 90% of respondents supported a formal training program with requirement to demonstrate proficiency; 80% believed this should be part of standard ACVS/ECVS residency training.ConclusionArthroscopic skills are taught by using clinical cases, with subjective proficiency assessment. Fundamental skills are those that may be taught using simulators. There is enthusiasm for formal arthroscopic skills training and assessment.Clinical significanceImproved acquisition and assessment of fundamental arthroscopic skills is indicated. A validated methodology for formal training using simulators, minimizing morbidity, and facilitating objective evaluation is warranted. This is the first phase of a project to develop and validate a simulator program.
A prospective, randomized, double‐blinded, placebo‐controlled clinical study on postoperative antibiotherapy in 150 arthroscopy‐assisted tibial plateau leveling osteotomies in dogs
Authors: Spencer Dustine D. , Daye R. Mark 
Published: September 2018

AbstractObjectiveTo determine the influence of a 7‐day course of postoperative antibiotherapy (cefpodoxime) on surgical site infections (SSI) after tibial plateau leveling osteotomy (TPLO).Study designProspective, randomized, double‐blinded, placebo‐controlled clinical study.Sample populationOne hundred fifty client‐owned dogs, with consent.MethodsDogs undergoing arthroscopy‐assisted TPLO were randomly assigned to 1 of 2 groups, the placebo group receiving perioperative cefazolin and 7 days of placebo medication after surgery or the treatment group receiving perioperative cefazolin and 7 days of postoperative cefpodoxime. Twenty‐seven factors were analyzed for association with SSI by using univariate analysis, Fisher's exact test, or Wilcoxon rank‐sum test.ResultsSSI rates did not differ (P = .34) between the placebo group (17%; 95% confidence level [CL] 7.94%‐26.43%) and the treatment group (11% SSI; 95% CL 3.98%‐18.88%). The probability that > 23% of dogs would benefit from postoperative antibiotherapy was less than 5%. The only association between the factors tested in this study and SSI involved the body weight (kg), with each 1 unit increase in kilogram weight increasing the odds of developing an SSI by 4.7%.ConclusionAlthough the wide CL may be consistent with a type II error, a 7‐day course of cefpodoxime after arthroscopy‐assisted TPLO did not influence postoperative SSI in the population tested here. In addition, only a small proportion of dogs would benefit from postoperative antibiotherapy under the conditions of our study.Clinical significanceThese results should prompt surgeons to reconsider systematic antibiotherapy after TPLO and justify additional studies to determine whether dogs predisposed to infection could benefit from such an approach.
Novel Experimental Study of Fabric Drying Using Direct-Contact Ultrasonic Vibration
Authors: Patel Viral K. , Kyle Reed Frederick , Kisner Roger , Peng Chang , Moghaddam Saeed , Mehdizadeh Momen Ayyoub 
Published: September 2018

Abstract
Fabric drying is an energy-intensive process, which generally involves blowing hot dry air across tumbling wet fabric to facilitate evaporation and moisture removal. Most of the energy supplied is used to overcome the enthalpy of vaporization for water. Although this process tends to be inefficient, it is fairly simple and forms the basis for the majority of existing clothes dryer technology today. To address the relatively low efficiency, a new method of drying called “direct contact ultrasonic fabric drying” is proposed. The process involves using high-frequency vibration introduced by piezoelectric transducers, which are in contact with wet fabric. The vibration is used to extract water droplets from the fabric mechanically. In this study, a total of 24 individual transducers are used in a module to dry a 142 cm2 sized fabric. The performance characterization of this single module has enabled successful scale-up of the system to a midscale prototype dryer, which can be used to ultrasonically dry clothing-sized fabric (∼750 cm2). The first-generation ultrasonic fabric dryer fabricated uses as little as 17% of the energy needed by traditional evaporation-based drying techniques. In addition to experimental data, this paper presents the results of a kinetic and scaling analysis that provides some important insights into ultrasonic drying.
Flow Structure and Heat Transfer Characteristics of a Rectangular Channel With Pin Fins and Dimples With Different Shapes
Authors: Luo Lei , Yan Han , Du Wei , Wang Songtao , Li Changhai , Zhang Xinghong 
Published: September 2018

Abstract
In this study, numerical simulations are conducted to investigate the effects of pin fin and dimple shape on the flow structure and heat transfer characteristics in a rectangular channel. The studied shapes for dimple and pin fin are circular, spanwise-elliptical, and streamwise-elliptical, respectively. The flow structure, friction factor, and heat transfer performance are obtained and analyzed with Reynolds number ranging from 10,000 to 50,000. Channel with circular pin fin and dimple is chosen as the Baseline. Channels with spanwise-elliptical pin fins have the best heat transfer augmentation, while also accompanied with the largest friction factor. Spanwise-elliptical pin fin generates the strongest horseshoe vortex which is responsible for the best heat transfer augmentation. Besides, channels with streamwise-elliptical pin fins show the worst heat transfer augmentation and the smallest friction factors. Dimple plays an important role in improving the heat transfer. Spanwise-elliptical dimple yields the best heat transfer augmentation which is attributed to the strongest counter-rotating vortex, while streamwise-elliptical dimple shows the worst heat transfer enhancement.
Associations between physical activity and cataract treated surgically in patients with diabetes: findings from the 45 and Up Study
Authors: Wu Changfan , Han Xiaotong , Yan Xixi , Shang Xianwen , Zhang Lei , He Mingguang 
Published: September 2018

AimTo investigate the association between physical activity (PA) and incidence of cataract surgery among patients with diabetes.MethodsWe obtained data from all diabetic subjects aged 45-65 years from the baseline of the prospective 45 and Up Study from 2006 to 2009 and linked to the Medicare Benefits Schedule (MBS) and Pharmaceutical Benefits Scheme (PBS) until 2016. Diabetes was defined as self-reported on questionnaire or diabetes medication history based on PBS. Cataract surgery was determined based on the MBS, and metabolic equivalent intensity level number of PA sessions per week was used to assess PA. Cox regression was used to assess the association between baseline PA and cataract surgery during the follow-up.ResultsA total of 9113 diabetic participants in the 45 and Up Study were included in the current analysis with a mean age of 57.3±5.2 years (43.6% female). During a mean follow-up of 8.8 years, 950 participants (10.4% of baseline) received cataract surgery with a corresponding incidence of 12.4/1000 person-years. Cox regression analysis showed that people with less PA (p=0.01), older age (p<0.001), female gender (p<0.001), higher educational level (p<0.001) and longer diabetic duration (p<0.001) had significantly higher cataract surgery risk. Participants with a PA level of ≥14 sessions per week had 19% decreased risk of cataract surgery compared to those with <5 sessions per week. Stratification analysis showed that participants with more obesity (p value for interaction=0.03), not taking insulin (p value for interaction=0.01) and without cardiovascular disease (p value for interaction=0.008) could benefit significantly more from PA in reducing their cataract surgery risk.ConclusionsMore vigorous PA was independently associated with a reduced risk of cataract surgery in working-aged patients with diabetes.
Temporal and spatial associations between influenza and asthma hospitalisations in New York City from 2002 to 2012: a longitudinal ecological study
Authors: Trinh Pauline , Jung Tae Hyun , Keene Danya , Demmer Ryan T , Perzanowski Matthew , Lovasi Gina 
Published: September 2018

ObjectivesTo determine whether asthma hospitalisations of children and adults in the five boroughs of New York City are correlated with influenza hospitalisations temporally and spatially.DesignA longitudinal ecological study.Inclusion criteriaWe reviewed the Statewide Planning and Research Cooperative System’s records of hospitalisations in Manhattan, Bronx, Queens, Brooklyn and Staten Island from 2002 to 2012. All hospitalisations with a primary diagnosis of either asthma or influenza were identified using the International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis codes.MethodsA time-series regression analysis was performed using aggregate monthly counts of influenza hospitalisations as predictors of asthma hospitalisations. Time-series regression models were also applied to different age groups and boroughs to examine the magnitude of influenza and asthma correlations across strata. The per cent excess risk was also calculated across age groups and boroughs.ResultsTime-series analysis of the overall population revealed a significant positive correlation between influenza and asthma hospitalisations (p=0.011). When stratifying by age, there was a significant positive correlation between asthma and influenza hospitalisations for individuals 18 and older (p<0.01), and no significant correlation found for age groups younger than 18. Percentages of excess risk of influenza-related asthma hospitalisations also increased with increasing age with adults 18–44, 45–64 and 65+ having excess risk percentages of 2.9%, 3.4% and 4%, respectively. Time-series analysis by location revealed positive significant correlations between asthma and influenza hospitalisations in Brooklyn (p=0.03) and Manhattan (p<0.01). Manhattan and Brooklyn had a 2.5% and 1.6%, respectively, percentage of excess risk of influenza-related asthma hospitalisations.ConclusionInfluenza and asthma hospitalisations are significantly associated at the population level among adults. These associations vary by age and geographical location. Influenza prevention strategies targeting adult populations, particularly individuals living in Manhattan and Brooklyn, have the potential for meaningful reduction of influenza-related asthma hospitalisations.
Perceptions of emergency care using a seizure care pathway for patients presenting to emergency departments in the North West of England following a seizure: a qualitative study
Authors: Male Leanne Rachel , Noble Adam , Snape Darlene Ann , Dixon Peter , Marson Tony 
Published: September 2018

ObjectivesTo establish the appropriateness of a previously developed seizure care pathway by exploring to what extent patients valued the intervention and perceived it as being helpful or not.DesignQualitative descriptive study, using semistructured, in-depth interviews and thematic template analysis, theoretically informed by critical realism.SettingIn North West England, a seizure care pathway has been developed in collaboration with a specialist neurology hospital to support clinical management of seizure patients on initial presentation to the emergency department (ED), as well as access to follow-up services on discharge, with the aim of improving patient experience. Three National Health Service (NHS) EDs and a specialist neurology hospital provided the setting for participant recruitment to this study.Participants181 patients fulfilled the inclusion criterion with 27 participants taking part following their experience of an ED attendance and outpatient follow-up appointment after a seizure.ResultsFive main themes emerged from the data: decision to seek care, responsiveness of services, waiting and efficiency, information and support, and care continuity. Two integrative themes spanned the whole study: lived experience and communication. This paper reports on two of the main themes: care continuity, and waiting and efficiency. The average time between ED presentation and interview completion was 100 days.ConclusionsImplementation of a care pathway is a complex intervention, requiring long-term follow-up to assess its integration into practice and effectiveness in service improvement. The seizure care pathway has the potential to enhance the care of seizure patients in the ED and at follow-up by improving continuity and management of care. The study demonstrates good aspects of the seizure care pathway as observed by patients and also recognises shortcomings within current service provision and questions what the NHS should and should not be delivering. Our study suggests various ways to enhance the pathway at service level to potentially drive improved patient experience.
Association of body mass index and age with incident diabetes in Chinese adults: a population-based cohort study
Authors: Chen Ying , Zhang Xiao-Ping , Yuan Jie , Cai Bo , Wang Xiao-Li , Wu Xiao-Li , Zhang Yue-Hua , Zhang Xiao-Yi , Yin Tong , Zhu Xiao-Hui , Gu Yun-Juan , Cui Shi-Wei , Lu Zhi-Qiang , Li Xiao-Ying 
Published: September 2018

ObjectiveType 2 diabetes mellitus is increasing in young adults, and greater adiposity is considered a major risk factor. However, whether there is an association between obesity and diabetes and how this might be impacted by age is not clear. Therefore, we investigated the association between body mass index (BMI) and diabetes across a wide range of age groups (20–30, 30–40, 40–50, 50–60, 60–70 and ≥70 years old).DesignWe performed a retrospective cohort study using healthy screening programme data.SettingA total of 211 833 adult Chinese persons >20 years old across 32 sites and 11 cities in China (Shanghai, Beijing, Nanjing, Suzhou, Shenzhen, Changzhou, Chengdu, Guangzhou, Hefei, Wuhan, Nantong) were selected for the study; these persons were free of diabetes at baseline.Primary and secondary outcome measuresFasting plasma glucose levels were measured and information regarding the history of diabetes was collected at each visit. Diabetes was diagnosed as fasting plasma glucose ≥7.00 mmol/L and/or self-reported diabetes. Patients were censored at the date of diagnosis or the final visit, whichever came first.ResultsWith a median follow-up of 3.1 years, 4174 of the 211 833 participants developed diabetes, with an age-adjusted incidence rate of 7.35 per 1000 persons. The risk of incident diabetes increased proportionally with increasing baseline BMI values, with a 23% increased risk of incident diabetes with each kg/m2increase in BMI (95% CI 1.22 to 1.24). Across all age groups, there was a linear association between BMI and the risk of incident diabetes, although there was a stronger association between BMI and incident diabetes in the younger age groups (age×BMI interaction, p<0.0001).ConclusionsAn increased BMI is also independently associated with a higher risk of developing diabetes in young adults and the effects of BMI on incident diabetes were accentuated in younger adults.