bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization combination antihypertensive therapy in patients with hypertension depending on indicators daily monitoring of blood pressure
Authors: Є. Х. Заремба  , О. В. Заремба-Федчишин  , М. М. Вірна  
Published: December 2018

The objective: improving the efficiency of the treatment of hypertension ІІ stage 2 3 degrees by studying the performance of daily blood pressure monitoring and correction of violations through the use of lisinopril with amlodipine and bisoprolol with amlodipine.Patients and methods. The results of daily monitoring of blood pressure in patients with hypertension stage II 2–3 degrees. The study involved 72 patients (34 men and 38 women), mean age was 54,6±8,11 years. Results. The use of combination antihypertensive therapy helps normalize blood pressure during the day, can achieve target levels of blood pressure in most patients. Under the influence of combination antihypertensive therapy is improving daily profile of blood pressure, a significant reduction of pathological types (non dipper, night peaker, over dipper), resulting in increased normal (dipper) degree nocturnal blood pressure reduction.Conclusion. The best treatment efficacy observed in patients who took turns bisoprolol with amlodipine and lisinopril with amlodipine.
Analysis of indicators of 24-h holter monitoring ECG in elderly hypertensive patients with atrial fibrillation
Authors: Л. В. Бевзюк  , Л. М. Єна  
Published: December 2018

The prevalence of essential hypertension (EH) defines its significance as the most important population – based risk factor for development of atrial fibrillation (AF). The heart morphological remodelling – the development of left ventricular hypertrophy and its diastolic dysfunc tion, the increase of left atrial sizes is associated with increased risk for the development of atrial and ventricular arrhythmias.The objective: to estimate the rate of arrhythmias in elderly hypertensive patients depending on the form of atrial fibrillation (AF) – persistent or permanent.Patients and methods. Doppler echocardiography and Holter monitoring ECG were investigated in 140 patients aged 60–74 years. The were 20 patients with uncomplicate EH, 60 patients with persistent (PersAF) and 60 – wits permanent (PermAF) AF.Results. It was established that patients EH have high frequency of single ventricular extrasystoles. The presence of AF in hypertensive patients is associated with the increase of myocardial electrical inhomogeneity, with is most expressed in permanent AF: the high gradation ventricular arrhythmias in patients with uncomplicated EH, PersAF and PermAF were 5%, 28% and 62% respectively. In study population the range of corrected QT interval (QTc) of these patients, 10% in EH, 16% – PersAF and 43% – PermAF, had prolonged QTc complexes. There were revealed correlations between dispersion of the QT interval (QTd) and parried ventricular extrasystole (r=0,26; р<0,05), between QTd and grouped ventricular extrasystole (r=0,25; р<0,05). Conclusions. It was found that groups of patients associated with the increase in the frequency and amount of daily, single ventricular extrasystoles and high gradation ventricular arrhythmias a set of structural and functional changes of the heart in elderly patients with arterial hypertension and atrial fibrillation and their relation to electrical heterogeneity of the myocardium.
Diagnostics and treatment of postoperative neuropathies of the trigeminal nerve in its bruises and stretching
Authors: Н. О. Ушко  
Published: December 2018

The objective: to study the dynamics of changes in electrophysiological indices of soft tissues innervated by II and III branches of the trigeminal nerve with its bruises and stretching, which arise in patients after surgical remove of tumors and tumor like jaw formations, and also determine the possibility of using the hardware software complex «DIN-1» for the treatment of these neuropathies. Patients and methods. a survey and treatment of neurological complications in 180 patients after surgical remove of tumors and tumor-like formations of the upper and lower jaws was performed.Results. based on the survey, we found that the determination of electrophysiological indices of soft tissues innervated by II and III branches of the trigeminal nerve in cases after performing operations to remove benign neoplasms of the jaws is not only a diagnostic criterion for the severity of damage to the trigeminal nerve in the surgical wound, but also can serve as a prognostic criterion, which indicates the timing of recovery of the nerve.Conclusions. The use of hardware-software complex «DIN-1» in the treatment allowed to reduce the treatment of all patients with neuropathies caused by bruises of the second and third branches of the trigeminal nerve by a factor of 2, and by 1,5 times the duration of treatment of patients with neuropathies caused by their stretching.
Neurovegetative and cognitive impairments associated with anxiety in middle-aged patients with underlying cerebrovascular diseases
Authors: Т. І. Насонова  , О. В. Кліменко  , Т. В. Колосова  , Г. В. Горєва  , Ю. І. Головченко  , О. В. Тишкевич  , О. М. Гурмак  
Published: December 2018

The objective: analysis of the treatment efficacy and safety of neurovegetative and cognitive impairments associated with anxiety in middle-aged patients with underlying cerebrovascular diseases (CVD)by means of Adaptol® medication.Patients and methods. There were examined 60 patients, aged 42 to 58, having neurovegetative as well as light and mild cognitive impairments with underlying anxiety and depressive disorders (30 patients – main group, treatment with Adaptol® administration, 30 patients – control group: standard treatment without Adaptol® administration). The study of cognitive, vegetative and neuropsychological disorders was performed with the use of clinical scales. We determined the cortisol levels: before the treatment,on the 7th day of treatment and afterthis treatment.Results. It was determined that the patients with chronic cerebrovascular diseases CVD of young and middle-age, have mild to moderate cognitive impairments with underlying vegetative and anxiety disorders. Revealed impairments are corrected well by administering promptly of antihypertensive, metabolic, lipid lowering, and glucose–lowering therapy and also by means of minor tranquilizer Adaptol® produced by Olaynfarm company, at the dose of 300 mg twice a day for 28 days period. The treatment resulted in a statistically significant decrease of autonomic dysfunction, situational and personal anxiety and in the improved cognitive functions according to MoCa scale in patients taking Adaptol® in comparison to the data before the treatment. The level of cortisol in the blood plasma decreased gradually after 7 days of treatment and on the 28th day reached a statistically significant difference (p<0,05) when we compared the patients’ baseline parameters in the main group who received Adaptol® to those ones of the control group patients.Conclusions. Patients with early signs of chronic CVD were diagnosed with cognitive and anxiety disorders with underlying neuroveg etative syndrome which required treatment. Minor tranquilizer Adaptol® produced by Olaynfarm company is recommended for treatment of psycho emotional disorders in middle aged patients with underlying neurovegetative syndrome as a part of an anxiety disorder.
Сontent of free heparin in the blood plasma, obtained by manual plasmapheresis
Authors: А. В. Корж  
Published: December 2018

The plasma samples of 34 primary donors (22 men and 12 women) for the first time given the plasma by automated plasmapheresis (control surveillance), and 54 active donors of blood plasma (40 men and 14 women) being donors with non less 14 days interval between donations, have been examined. The active male donors’ plasma averaged at 18,63±1,71 with individual index fluctuations from 2 to 78, female donors’ – 14,09±1,95 with individual index fluctuations from 2 to 45. The method of plasma obtaining – manual plasmapheresis method. The surveyed groups were homogeneous for age and sex. Hematologic and biochemical parameters of all those persons have been examinedand, basing on the conclusion of the professionals, everyone was admitted to the plasma donation. The content of free heparin in plasma were determined by metod of Mikhailichenko B.V., Vydyborets S.V. (2000). Analysis of the results showed that in the donor plasma samples obtained by manual plasmapheresis level of free heparin is significantly higher
Finding of violations of iron and the morphometric analisis of the erythrocytes in blood donors
Authors: Л. А. Песоцька  
Published: December 2018

The objective: study the parameters of iron metabolism and morphometric analysis of peripheral blood erythrocytes in active donors for the detection of specific changes in erythrocytes.Patients and methods. 92 donors aged 20 to 55 (48 men and 44 women) were divided into two groups. The first group included 29 people who donated for the first time in their lives, in the second group – 63 regular donors with more than two years of donor experience at least two donations per year.Results. The results of a study of iron metabolism parameters in serum: the serum iron levels, total iron binding capacity and the serum iron saturation in the article are presented. The article dealt with the study results of the morphometric erythrocytes changes in peripheral blood. The importance of the morphometric erythrocytes changes in periph eral blood in regular blood donors is discussed.Conclusion. Further study of pathophysiological and biochemical changes in the erythrocyte link of the homeostasis of active donors is a promising direction of scientific research. Its implementation will improve the patterns of pathogenetically grounded preventive treatment of latent iron deficiency in this category of donors, ultimately contribute to the preservation of the human resource potential of donors and ensure the high quality of blood components.
Use of the drug Rehydron Bio in the complex therapy of rotavirus infection
Authors: А. І. Савчук  , В. Р. Гайдей  , Л. К. Бошкова  , С. І. Доан  , С. О. Костенко  
Published: December 2018

Objective: to study efficiency of using the drug Rehydron Bio in the treatment of rotavirus infection (RVI) in children.Materials and methods. The study included 58 children aged from 3 to 8 years, who were treated in Odesa City Clinical Infectious Diseases Hospital because of RVI. Patients of the main group (n = 26) received basic therapy that included that included low lactose diet, intestinal antiseptic nifuroxazide in the age medium therapeutic dose, chelators and enzymes.. For the purpose of oral rehydration main group of patients received the drug Rehydron Bio that produced by «Orion Corporation» (Finland) rate 3–6 days. The control group included 32 children who, along with basic treatment for oral rehydration used rehydron, sweetened tea and degassed mineral water. During hospitalization patients conducted a comprehensive survey, which included an objective review of clinical and biochemical blood and urine.Results. During the using of the drug Rehydron Bio, the necessity for infusion therapy for rehydration aim occurred significantly less often, which confirms its high efficiency. Conclusion. Use of the drug Rehydron Bio for the purpose of oral rehydration in children with rotavirus infection contributed to the rapid improvement of the patient, eliminating the symptoms of toxicity, and dehydration, reduced the need for the appointment of infusion therapy, which indicates its high efficiency and give an opportunity to recommend the drug for oral rehydration in patients with viral diarrhea.
Rehabilitation of patients with diabetes mellitus
Authors: Л. С. Бабінець  , О. В. Редьква  , Г. М. Сасик  
Published: December 2018

The objective: to study the effectiveness of acupuncture in the complex rehabilitation of patients with type 2 diabetes mellitus (DM) on the basis of assessment of clinical parameters and quality of life (QOL).Materials and methods. 40 patients with type 2 diabetes mellitus were examined. The comparison group included 15 healthy individuals, who did not have any complaints about their health. All 55 examined were divided into three groups: Group I – 20 patients with type 2 diabetes with clinically pronounced lower limb angiopathy (LLA); Group II – 20 patients with type 2 diabetes with clinically significant LLA; ІІІ (control) group – 15 practically healthy persons, who did not have any complaints about the state of health. All patients with type 2 diabetes received adequate drug therapy, which included metformin or sulfonylureas in individually matched doses. In addition to treatment, Group II patients received a needle reflexotherapy course (RT) according to a methodology that was formed on the basis of the findings of the Kiev school of classical acupuncture and the Peking school, which included 11 sessions.Results. After the complex treatment, there was a decrease in the severity of clinical manifestations of LLA in both groups, but more significantly the treatment affected group II patients. It was found that the use of RT in the complex rehabilitation of patients with type 2 diabetes, as well as patients with concomitant LLA, positively influenced QOL.Conclusions. The article is devoted to the study of patients with type 2 diabetes, which proved that complex treatment with the using of acupuncture according to the proposed method led to a more significant dynamics of clinical and laboratory parameters compared with the following groups of commonly accepted treatment: the blood supply to the legs increased by 7,76 % (p<0,001) versus 2,28% (p>0,05), foot blood supply – by 9,13% (p<0,01) versus 4,79% (p<0,05) (according to the rheovasography). The level of glucose decreased by 11,33% (p<0,01) versus 7,69% (p<0,005) and HbA1c was 4,46% (p<0,005) versus 1,71% (p>0,05) respectively, determined after 3 months under the complex of treatment, indicating the sustainability of the effect of the proposed integrated rehabilitation scheme. With a comprehensive assessment of the dynamics of quality of life, it was found that in the group of patients with diabetes mellitus and angiopathy of the lower extremities, which included a course of acupuncture in the generally accepted treatment, a more significant positive dynamics of the indicator of mental status (increased by 17,75% (p<0.001) against 8,71% (p<0,005) respectively) and physical status (increased by 2,59% (p<0,05) versus 7,19% (p<0,05).
The impact of exchange rate on price and export of agricultural production
Authors: Tulkin Sattarovich Rasulov , Kuvonchbek Ravshanovich Khushvaktov 
Published: December 2018

In today’s world of swiftly increasing global economy and continuously changing international trade laws and technology exchange rate plays a pivotal role in the production, price formation, export and import of agricultural products. For many years exchange rate as an integral part of agricultural economics has been ignored.
The present study was intended to investigate exchange rate as an impacting factor on the agricultural production. It also considers the researches that have been carried about the impact of the exchange rate on prices and export of agricultural products, theirs analyses and how much impact it has in the situation of Uzbekistan.
A note on some recent results of the conformable fractional derivative
Authors: BİRGANİ O. Taghipour , CHANDOK Sumit , DEDOVİC Nebojsa , RADENOVİC Stojan 
Published: December 2018

In this note, we discuss, improve and complement some recent results of the conformable fractional derivative introduced and established by Katugampola[arxiv:1410.6535v1] and Khalil et al. [J. Comput. Appl. Math. 264(2014) 65-70]. Among other things we show that each function $f$ defined on $(a,b)$, $a&gt;0$ has a conformable fractional derivative (CFD) if and only if it has a classical first derivative. At the end of the paper, we prove the Rolle's, Cauchy, Lagrange's and Darboux's theorem in the context of Conformable Fractional Derivatives.
Problematic aspects of euro integration process of Ukraine's agro-industrial complex
Authors: Studinski Volodymyr , Romanchuk Kateryna 
Published: December 2018

The purpose of the article is to identify the main advantages and risks for domestic agricultural producers in the process of integration into European space and to assess their impact on the development of the domestic agricultural sector. The proposed article analyzes the prospects and risks of integration of domestic agricultural enterprises into world economy. Special attention is focused on the export and import of agricultural products and the achievement of Ukraine in the field of agro-industrial complex. An estimation of foreign economic activity of agrarian enterprises of Ukraine is conducted. The implications of the implementation of the Association Agreement between Ukraine and the EU for various sectors of the economy of Ukraine, and most especially for the agrarian sector, are assessed and analyzed. The potential benefits of signing the Comprehensive Free Trade Area Agreement for the development of the agrarian sector have been explored. Perspectives are considered and risks of European integration for agrarian enterprises and development of rural territories are analyzed. It is established that European integration for Ukraine is a way to modernize the domestic agricultural production, attract foreign investments and new technologies, increase the competitiveness of products, obtain financial resources for the development of the economy. Conclusions. Thus, the Ukrainian agro-industrial complex has a serious economic potential which allows it to be in a positive dynamics and has good prospects of integration into the European space. At the same time, this process should fit into the overall context of reforms and sectoral changes in Ukraine's economy. Alongside with it, the state plays an important role in the regulatory processes of managing the economy in general and the agrarian sector in particular.
Urbanization as a challenge for the food safety of a country
Authors: Sheludko Lesya 
Published: December 2018

Actuality of the research topic. A number of global trends affects food supply and consumption, as well as food security in the world. The main one is the growth of the world population primarily in emerging countries and urbanization of the population. Accordingly, the topic of food security in the context of urbanization becomes highly relevant. Problem statement. It should be noted, that urbanization changes the quantity and structure of food products, increases the demand for quality products, impacts on food security and economic security of the country in general. Review of recent research and publications. Urbanization is a very complex subject; so many well-known foreign and domestic scientists from different fields of science have studied various aspects of urbanization. At the same time, the vast majority of publications are mostly theoretical and cover the demographic and geographical aspects of urban processes, while the issues of economic analysis and the impact of urbanization on food security remain inadequately studied. Task statement, research methods. The article aims to study the process of urbanization in the world and in Ukraine, as well as to identify the impact of urban processes on the economic development of countries and food security in order to develop recommendations on prospects and opportunities for Ukraine. Presentation of the main material (results of work). The paper describes the main processes of urbanization, which take place in different countries and in the world as a whole, as well as in Ukraine. The influence of urbanization processes on the economic development of the countries is determined, namely, that the countries with high level of urbanization have high economic development and accordingly the high Gross National Product per capita. It has been discovered, that urbanization also affects the food security of countries, as the number of urban population increases, the structure of consumer products changes, and the demand for food increases as well. Summary. Urbanization represents both a challenge and an opportunity for the development of agriculture, as well as food security. Urbanization provides opportunities for Ukraine in the face of growing demand for food, to improve its export potential.
Концептуальні засади стратегічного управління розвитком молокопереробних підприємств
Authors: Kryukova Iryna , Stoyanova-Koval Svitlana 
Published: December 2018

Предмет, мета роботи. У статті здійснено дослідження теоретичних та практичних аспектів стратегічного управління молокопереробними підприємствами. Здійснена оцінка сучасного стану розвитку підприємств молокопереробної галузі. Проведено порівняння методичних засад оперативного і стратегічного менеджменту бізнес-суб’єктів галузі. Обґрунтовано складові процесу стратегічного управління молокопереробних компаній. Метод або методологія проведення роботи. При здійсненні наукових досліджень було використано сукупність наступних методів і прийомів наукового пізнання: абстрактно-логічний (при формуванні логіко-структурної схеми процесу стратегічного управління), монографічний та економіко-статистичний (при оцінці сучасного стану розвитку молокопереробної галузі), методи аналізу і синтезу (при формалізації та оцінці дії факторів на процес стратегічного управління), метод наукового порівняння. Результат роботи. За результатами дослідження встановлено, що в умовах загострення конкуренції та посилення ризиків економічного середовища процес менеджменту підприємств молокопереробної галузі має орієнтуватись на стратегічну перспективу. Систематизація наукових підходів до стратегічного управління дозволила визначити, що його слід трактувати у тісному зв’язку із потенціалом компанії, факторами зовнішнього і внутрішнього середовища, сукупністю функціональних цілей бізнес-суб’єкта. Аналіз сучасного стану розвитку молокопереробної галузі України показав наявність значного потенціалу виробництва поряд із існуючим дисбалансом внутрішніх тенденцій функціонування галузі. Разом з тим, досягнення значних успіхів на ринку молокопродуктів сьогодні виявляється неможливим без імплементації засад стратегічного управління у діяльність молокопереробних компаній. За дослідженнями системних переваг стратегічно орієнтованих бізнес-структур обґрунтовано етапність та основні складові процесу стратегічного управління сучасних молокопереробних підприємств. Галузь застосування результатів. Отримані результати можуть бути використані при обґрунтуванні та реалізації стратегічних засад управління підприємств молокопереробної сфери АПВ. Висновки. Наявні методичні підходи до сутності стратегічного управління сьогодні демонструють відсутність єдиної концепції до обґрунтування процесу стратегічного управління бізнес-суб’єктами. Разом з тим, систематизація наукових поглядів дозволяє виділити ключові аспекти такої концепції, на засадах яких має ґрунтуватись стратегічне управління: оригінальність та диверсифікація пропозиції на ринку; максимізація ринкової вартості бізнесу; забезпечення синергійного ефекту менеджменту; адаптивність та результативність управлінського процесу. Порівняння оперативного і стратегічного управління свідчить про значний потенціал підвищення результативності менеджменту за умов імплементації стратегічних підходів до управлінського процесу молокопереробних підприємств.