bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and Clinical Predictors of Atrial Fibrillation in Patients with Dual-Chamber Pacemakers: A Retrospective Analysis
Authors: Ungureanu Adrian-Ionuţ , Negroiu Cristina Elena , Docea Anca Oana , Goanţă Emilia-Violeta , Târtea Georgică , Aniculăesei Anca-Adela , Mărginean Cristina Maria , Mitruţ Radu , Deutsch Marina-Carmen , Vătășescu Radu-Gabriel , Mitruţ Paul 
Published: November 2024

Abstract
Atrial fibrillation (AF) is a prevalent cardiac arrhythmia, affecting millions worldwide and increasing in frequency with age. Despite progress in treatment and prevention, AF remains a significant contributor to stroke, heart failure, and overall cardiovascular morbidity. One particularly challenging type of AF, paroxysmal atrial fibrillation (PAF), is often asymptomatic, leading to delayed diagnosis and increasing the risk of severe complications like stroke. The advent of cardiac implantable electronic devices (CIEDs) has significantly improved the ability to detect subclinical AF or atrial high-rate episodes (AHRE), even in patients with no symptoms. These devices, particularly pacemakers, offer long-term, continuous monitoring of atrial rhythms, making them an invaluable tool for diagnosing AF early and assessing its burden in real time.
This study focused on a cohort of patients from the Oltenia region who received dual-chamber pacemakers with no prior diagnosis of AF. The research aimed to monitor the incidence of AF in these patients over a follow-up period of 12 to 18 months and to identify potential clinical predictors for developing AF. A total of 91 patients were assessed in this study, all of whom received dual-chamber pacemakers by the pacing guidelines for conditions such as atrioventricular block and sick sinus syndrome. None of the patients had a history of AF at the time of implantation.
Follow-up results indicated an incidence of AHRE in 13.19% of patients, with significant predictors including advanced age and the presence of hypertension. These findings align with the broader literature, which consistently associates both factors with an increased risk of AF. The study underscores the importance of continuous monitoring in pacemaker patients, particularly for detecting asymptomatic AF, which may necessitate specific therapeutic interventions. Although the study’s sample size was limited, its findings contribute valuable insights into managing AF in pacemaker patients, particularly regarding early detection and potential risk factors. Future research with larger cohorts is necessary to confirm and expand these results.
Non-Pharmacological Management of Insomnia in Cancer Patients
Authors: Plăcintă Carmen Denisa , Brotea-Mosoiu Silvia Alina , Șerban Cătălina Elena , Galeș Laurenţia Nicoleta 
Published: November 2024

Abstract

Introduction. Insomnia is a common sleep disorder in cancer patients, characterized by a reduction in the quality or quantity of sleep. It can lead to fatigue, mood disturbances, and may contribute to immunosuppression, affecting both disease progression and quality of life.

Materials and methods. In an attempt to answer the question: “Does non-pharmacological treatment of insomnia improve the quality of life in cancer patients?”, we conducted a systematic search in the international databases PubMed and ScienceDirect, following the PRISMA guidelines. The search keywords were “insomnia,” “sleep disorders,” “cancer,” and “quality of life.”

Results. The systematic review included eight randomized trials that evaluated the effect of non-pharmacological therapies on insomnia and quality of life in oncology patients. Cognitive-behavioral therapy (CBT) is the first-line treatment with proven efficacy. Variants of CBT delivered through online platforms were found to be non-inferior in studies involving small patient groups. Another alternative treatment is acupuncture, which, while not as effective as CBT, improves sleep quality and enhances quality of life. Physical exercise, dance, nutrition programs, and psychological counseling also improve sleep and enhance quality of life compared to the usual hospital approaches.

Conclusions. Non-pharmacological treatment of insomnia improves the quality of life in cancer patients.
Chronic Kidney Disease and Oxidative Stress
Authors: Stoian Marilena , Gavrilă Bogdan , Ciofu Claudia , Turbatu Andrei 
Published: November 2024

Abstract
Disturbance of the balance between production of oxygen free radicals (or some other radical species) and activity of antioxidative system of protection causes the so called oxidative stress Protection of an organism from oxygen free radicals implies activity of enzymatic (catalase, SOD, glutathione peroxidase, glutathione reductase etc.) and nonenzymatic (vitamin E. vitamin C. glutathione, uric acid etc.) systems of protection. An organism can tolerate a mild oxidative stress but a higher disturbance between the production of free radicals and the activity of the antioxidative protection results in lipid protein and DNA as well as numerous diseases. In this article we analyze oxidative stress role as an important cofactor contributing to endothelial dysfunction, inflammation, atherosclerosis, glomerulosclerosis, anemia, tubulointerstitial nephritis and ischemia-reperfusion injury to chronic kidney disease patients.
Diagnostic and Therapeutic Meanders in a Wegener Disease - Case Report and Therapeutic Challenges
Authors: Cotea Andrei-Antonio , Mihălţan Florin-Dumitru , Mălăescu Andreea-Nicoleta , Constantin Ancuţa-Alina 
Published: November 2024

Abstract
Granulomatosis with polyangiitis (GPA), previously known as Wegener’s granulomatosis, is a vasculitis that primarily affects the respiratory tract and kidneys(1). Known as a rare disease, predominantly affects Caucasian adults aged between 45 and 60 years(2). While the specific cause remains unclear, it is believed that environmental factors play a role in triggering the condition in individuals who are genetically predisposed(3).
There is a wide range of clinical manifestations, comprising both general nonspecific symptoms(4) and organ-specific symptoms, with lung involvement in nearly 90% of patients(5). The diagnosis relies on clinical and imaging criteria, along with histopathological confirmation(2). Treatment consists of an induction phase, followed by a maintenance phase, utilizing glucocorticoids and immunosuppressants, which has greatly enhanced the prognosis for these patients(6).
The objective of this paper is to illustrate the complexity of GPA through the presentation of a clinical case. The patient is a 59-year-old man with a professional background involving exposure to respiratory toxins who presented to the clinic with intermittent mucopurulent cough, episodes of hemoptysis, nonspecific chest pain, bilateral knee pain, weight loss, and excessive nocturnal sweating. The imaging findings indicated significant polymorphic lesions in the lungs, and the diagnosis of GPA was confirmed via transthoracic biopsy.
Using a therapeutic strategy of immunosuppression and oral corticosteroid therapy, the patient’s clinical condition showed a modest improvement. The particularity of this case lies in the need to revise the treatment strategy for a patient identified as a non-responder to cyclophosphamide, given the imaging, functional and biological decline observed under the initial immunosuppressive therapy.
c ANCA Antibodies and Infective Endocarditis -Friends Or Foes?
Authors: Buican Luiza , Stanciu Silviu , Iordache Mihaela , Iancu Diana , Constantin Ramona , Stan Liviu , Dumitrescu Silviu , Gurzun Maria Magdalena 
Published: November 2024

Abstract
The differential diagnosis between granulomatosis with polyangiitis (GPA) and infective endocarditis (IE) is crucial. Both diseases show clinical similarities and serologic c-ANCA overlap. We present the case of a 45-year-old patient with inflammatory and anemic syndrome, c-ANCA positivity and initial respiratory and renal symptoms that raised the suspicion of GPA. Subsequent evolution revealed severe valve involvement and the presence of Streptococcus gallolyticus in blood cultures, confirming the diagnosis of infective endocarditis. Antibiotic treatment and surgical intervention were crucial for the patient’s recovery. This case demonstrates the importance of imaging and microbiological examinations for the correct differentiation of these diseases and the importance of a multidisciplinary approach.
Cardiac Tamponade, First Sign of Onset of Systemic Lupus Erythematosus
Authors: Anghel Daniela , Mihalca Liana-Ioana , Petrache Oana-Georgiana , Nicolau Iulia-Nadine , Mihai Ancuţa 
Published: November 2024

Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease with various clinical manifestations that can affect multiple organs and systems. One of the severe complications associated with SLE is cardiac tamponade, a rare and life-threatening complication. In this paper, we present the case of a 36-year-old woman who was diagnosed with SLE after an episode of cardiac tamponade. Large pericardial effusions with cardiac tamponade are rarely encountered in SLE, particularly as the onset of the disease. This case highlights the importance of early recognition of cardiac tamponade and raises awareness of the fact that SLE can present with cardiac involvement, such as cardiac tamponade, at the onset of the disease. Multidisciplinary care involving rheumatologists, cardiologists, and other specialists is essential in the management of SLE with cardiac complications.
Left Bundle Pacing for Third-Degree Atrioventricular Block in a Patient with Obstructive Hypertrophic Cardiomyopathy
Authors: Ionescu Diana Andreea , Barbu Florin , Bădilă Elisabeta , Deutsch Alexandru 
Published: November 2024

Abstract
Ventricular arrhythmias are common in patients with obstructive hypertrophic cardiomyopathy (HOCM) and can cause syncope and sudden death, but conduction disturbances are rarely associated with obstructive hypertrophic cardiomyopathy.
Cardiac physiologic pacing can be achieved by stimulating the intrinsic conduction system via conduction system pacing (Hiss bundle, left bundle branch-LBB- or left bundle branch area pacing). This technique can be challenging in HOCM due to septal hypertrophy. Our literature review did not find such a case reported so far where LBB area pacing was performed in a patient with HOCM with satisfying results and with the improvement of outflow obstruction of the left ventricle. Here we describe a case of a 57-year-old man with obstructive hypertrophic cardiomyopathy and third-degree atrioventricular (AV) block who presented in our cardiology department for dyspnea and fatigue. This patient was treated with LBB area pacing and recovered well.
Prosthetic restoration in frontal maxillary area using digital technologies: Case presentation (Part I)
Authors: David Mihai , Radu Elena Georgiana , Perieanu Viorel Stefan , Burlibasa Andrei , Stetiu Maria Antonia , Caministeanu Florentina , Popescu Mircea , Burlibasa Mihai , Chirila Mihaela 
Published: November 2024

Abstract
Digital technologies represent new alternatives in prosthetic rehabilitation of all kinds of maxillary or mandibular spans. This article is composed of two parts, in which different technological aspects will be presented regarding the prosthetic restoration of frontal maxillary areas using the CAD-CAM technology, but using different material for resistance framework, both veneered with ceramic materials to restore the aesthetics. The main materials that will be used are: Co-Cr dental alloy and zirconium dioxide (zirconia).
Exploring the Dynamics of Innovation in the Era of Artificial Intelligence
Authors: Maier Andreea , Osoian Codruța 
Published: November 2024

Abstract
Artificial Intelligence (AI) is revolutionizing the landscape of innovation, presenting both unprecedented opportunities and many challenges for individuals, organizations, and societies. The purpose of this paper is to investigate what will happen with innovation in an AI era, through a comprehensive analysis of the dynamics of innovation in the era of AI. Based on a bibliometric analysis we explore the paper annual publication number, the trend topic, the word count and the international interest for this subject. Through an in-dept analysis we observed some transformative changes that will arise: Data-Driven Decision Making, Personalized Customer Experiences, Supply Chain Optimization, Innovation in Financial Services, AI-Powered Entrepreneurship, Job Displacement and Reskilling, Ethical and Regulatory Considerations. By integrating insights from both bibliometric analyses and scenario planning exercises, we offer a nuanced understanding of the opportunities and challenges arising from AI-driven innovation and provide strategic recommendations for navigating the complex terrain of the AI era. The findings contribute to the academic discourse on AI and innovation, inform evidence-based decision-making, and inspire proactive responses to the transformative forces shaping our collective future.
The Impact of Social Norms on Foreign Direct Investments
Authors: Vlad Ioana Maria 
Published: November 2024

Abstract
This study examines the impact of social norms, measured through the Cultural Tightness-Looseness (CTL) index, on foreign direct investments (FDI) across 67 countries. I aimed to highlight a new approach from the sphere of cultural influences on bilateral FDI flows and to demonstrate the direct connection between the strictness imposed by a country’s social norms and the investment decisions based on them. The results obtained were in line with the initial expectations, validating the level of constraint/permissiveness as a truly influential factor in relation to foreign direct investments.
The Nexus Between Investors’ Sentiment and Hedge Funds Risk Premiums
Authors: Vodă Tudor-Ovidiu 
Published: November 2024

Abstract
In this study, we analyzed how the systematic risk of hedge funds affects different portfolio strategies. Using monthly returns data from a sample of developed market hedge funds grouped by five strategies, we identified the systematic factors influencing returns variation from January 2003 to December 2023. Market, size effect, momentum, investment effect, and bond spread were found to be the main risk factors explaining hedge fund returns dynamics. We proposed an enhanced version of the Fung and Hsieh (2004a) model, which demonstrated improved representativity with Baker and Wurgler sentiment index included as a risk premium. The quantile regression revealed that for most strategies, the estimated models performed better for the bottom quantiles.
Authors: Wira Andini Luh Gede Rahma , Anom Purbawangsa Ida Bagus 
Published: November 2024

Company management is responsible for managing business to achieve sustainability and increase the firm value. This research aims to determine the role of environmental performance in moderating the relationship between profitability and gross domestic product (GDP) on firm value. The population this study companies registered with PROPER on the Indonesia Stock Exchange for the period 2019 - 2023. PROPER is a company performance rating assessment program in environmental management. The sampling technique used was a saturated sampling technique, examining the entire population, with a total sample of 84 companies. The data analysis technique uses the moderated regression analysis (MRA) technique. Based on the results of this research analysis, profitability has a significant positive effect on firm value, gross domestic product has significant negative effect on firm value, environmental performance is unable to moderate the effect of profitability on firm value, and environmental performance is unable to moderate the effect of gross domestic product on firm value. The results of this study are expected to be considered by company management and investors.
Climate Parameters and Respiratory and Cardiovascular Diseases in a Municipality of the Legal Amazon
Authors: Pereira Alice Maria de Arruda , Olinda Ricardo Alves de , Santos Débora Aparecida da Silva , Goulart Letícia Silveira 
Published: November 2024

Objective: This study aims to investigate the relationship between climate parameters and respiratory and cardiovascular diseases in a municipality of the Legal Amazon in 2022. The intention is to provide data that assist in creating actions to reduce the impacts of pollution on human health.

Theoretical Framework: The research is based on the Theory of Climate Variability and Health and the Climate-Disease Correlation Model, which explore the relationship between climate and health. The Effects of Climate Change on Health are also discussed, providing a solid foundation for the study.

Method: The study is epidemiological and retrospective. Climate data (humidity, temperature, and precipitation) were obtained from a national meteorological database. Health data were collected from records of the Municipal Health Department of Rondonópolis, MT. The study period was from January 1 to December 31, 2022. The Spearman correlation test was applied.

Results and Discussion: Respiratory morbidities had the highest records in January (n: 1368), and cardiovascular cases were recorded in March (n: 6) and May (n: 6). There was no significant correlation between the diseases and the climate parameters studied.

Research Implications: It is suggested that studies consider other factors, and preventive actions be adopted during the months of highest disease incidence.

Originality/Value: The study provided important information about climate parameters and the distribution of cases of respiratory and cardiovascular diseases that will assist in planning prevention and control strategies.
Analysis of the quality of life in patients with multiple sclerosis within 3 years after high-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation
Authors: Polushin A. Yu. , Lopatina E. I. , Tsynchenko A. A. , Zalyalov Yu. R. , Skiba I. B. , Nikitina T. P. , Porfirieva N. M. , Ionova T. I. , Totolyan N. A. , Kulagin A. D. 
Published: November 2024

Introduction. To date, data have been accumulated indicating the high effectiveness of the HDIT-AHSCT and the possibility of preserving and improving the quality of life of patients after its application.The objective was to analyze the dynamics of quality of life using standardized assessment tools in patients with MS for 3 years after the use of HDIT-AHSCT, who participated in the program of clinical approbation of the method.Methods and materials. The single-center observational study included 21 patients (10 women, 11 men) with a reliable diagnosis of MS, who underwent HDIT-AHSCT at the Pavlov First Saint Petersburg State Medical Universityin accordance with the protocol of clinical approbation. Distribution by type of MS course: remitting (RMS) 16 (76.2 %), secondary progressive (SPMS) 4 (19 %), primary progressive (PPMS) 1 patient (4.8 %). The assessment of quality of life (SF-36, FAMS, CSP-MS42, HADS) and severity of disability (EDSS) in all patients was performed before, 12 and 36 months after HDIT-AHSCT.Results. Three years after the HDIT-AHSCT, a significant decrease in weakness, feelings of constant fatigue and rapid fatigue during exertion was recorded. The level of anxiety decreased in more than 50 % of patients. A direct relationship between the dynamics of clinical characteristics and the data of the scales of the SF-36 questionnaire was revealed; at the same time, after 36 months, an improvement in all parameters of the scale was noted.Conclusion. The assessment of the indicators of the quality of life questionnaires allows us to confirm the effectiveness and significance of therapy not only from the point of view of objective clinical and radiation parameters necessary for the evidence base of the treatment method, but also from the patient’s position, which in conditions of a chronic progressive process is an integral factor for the appointment of therapeutic intervention.
Asymmetry of the Trunk and Lower Extremity Joint Frontal Plane Kinematics During Single-Leg Standing and Squat in Paralympic Athletes With Upper Limb Deficiency Compared With Intact Athletes
Authors: Okamoto Shogo , Shimada Yui , Inoue Natsuka , Henderson Frederick James , Yamashita Daichi 
Published: November 2024

OBJECTIVE: To compare trunk and lower extremity asymmetries in frontal and sagittal kinematics between athletes with upper limb deficiency (ULD) and intact athletes during bilateral-leg standing (BLST), single-leg standing (SLST), and single-leg squat (SLSQ). DESIGN: Cross-sectional study. METHODS: Eleven elite Paralympic athletes with ULD and 11 elite intact athletes performed BLST, SLST, and SLSQ. Angles of the trunk, pelvis, hip, knee, and ankle were recorded using fixed cameras in the frontal and sagittal planes. Kinematic asymmetries between groups as well as the relationship between loss of mass relative to body mass (LM%) and ipsilateral trunk tilt were analyzed. RESULTS: Paralympic athletes exhibited greater ipsilateral trunk tilt during ULD side SLSQ (∆ = 7.1°, P = .02, d = 1.26) compared with intact athletes, but not during intact-side SLSQ. No significant correlation was found between LM% and bilateral angle differences in the frontal plane among Paralympic athletes ( P>.05, .06 ≤ | r| ≤ .27). CONCLUSION: Athletes with ULD compensated for missing body mass by tilting their trunk over their support leg when performing SLSQ only on the ULD side. The amount of trunk tilt did not seem to depend on the amount of missing mass. JOSPT Open 2025;3(2):1-8. Epub 5 November 2024. doi:10.2519/josptopen.2024.0074
Stroboscopic Vision Decreases Performance on the Y-Balance Test in Youth Athletes
Authors: Habegger Alex , Savage Jessica , Goodrich Richard , Curtis Daniel , Traywick LaVona , Young Allison , Kahl Dana , Conrad Will , James Dawn 
Published: November 2024

OBJECTIVE: To evaluate if stroboscopic vision significantly affected dynamic balance performance on the Y-Balance Test Lower Quarter (YBT-LQ) in athletes aged 12 to 18 years. DESIGN: Single-group pretest, posttest quasi-experimental study METHODS: Two hundred seventy-two participants aged 12 to 18 years, who participated in a school- or club-sponsored sport, performed the YBT-LQ without and with stroboscopic vision. Reach distances were recorded for each participant with and without stroboscopic vision. Main effects were analyzed to interpret the effect of stroboscopic vision on YBT-LQ performance, and secondary effects were analyzed to interpret the effect on individual reach directions and composite scores. RESULTS: There were significant main effects between YBT-LQ scores with and without stroboscopic vision ( P≤.001). Post hoc analyses identified a significant decrease in performance when participants performed the YBT-LQ with stroboscopic vision compared to the YBT-LQ under standard conditions in each reach direction, for left and right lower extremities. There was a significant decrease in composite scores when controlling for leg length of the participants. CONCLUSION: Performance of the YBT-LQ decreases when youth athletes’ vision is perturbed with stroboscopic vision. JOSPT Open 2025;3(1):30-34. Epub 5 November 2024. doi:10.2519/josptopen.2024.1243