bluuebunny/crossref_metadata_2025_split huggingface dataset:
Satisfactory performance of the Abbott ARCHITECT i2000 tacrolimus Immunoassay against the LC-MS/MS tacrolimus assay demonstrated in kidney transplant patients from the Northern Territory, Australia
Authors: Rathnayake Geetha , Mogulla Manohar Reddy , Ashford Jenna , Karepalli Vijay , Sallustio Benedetta C , Majoni Sandawana William 
Published: June 2019

Abstract
Background

Tacrolimus, a post-transplant immunosuppressive drug with a narrow therapeutic window requires close monitoring of levels to avoid under-immunosuppression or toxicity. Top End Renal Services in the Northern Territory (NT) refer to South Australia (SA) for drug levels as there was no local service. We aimed to evaluate the Abbott ARCHITECTi2000 immunoassay against the liquid chemistry tandem mass spectroscopy (LC-MS/MS) used in SA for measuring tacrolimus levels to provide on-site service in NT.

Methods

465 specimens were collected over 5 months and analyzed over several reagent lots. We used Passing-Bablok regression plots and Bland–Altman plots to assess the agreement between tacrolimus levels on both platforms.

Results

The Passing-Bablok regression plot demonstrated a slope of 1.172 (CI 1.136 to 1.207) with an intercept of 0.262 (CI 0.040 to 0.472). In Deming analysis, the slope was 1.095 (CI 1.074 to 1.116) with an intercept of 0.773 (CI 0.592 to 0.955), correlation coefficient (r) was 0.9782. Bland-Altman plot demonstrated positive bias for Abbott ARCHITECT results. The mean absolute bias was 1.494 ug/L and the mean percentage bias was 18.78%. Within run imprecision, Co-efficient of Variation (%) was 5.1, 2.7, 4.3, 3.4 and 3.5 at tacrolimus concentration levels of 4.2, 6.5, 9.5, 17.2 and 24.4 µg/L. Results turnaround time improved by 80%.

Conclusion

The results demonstrate that Abbott ARCHITECT i2000 is an acceptable method to monitor levels of tacrolimus. The positive bias could be justifiable if the drug levels are initially based and then monitored on results from the same platform.
Does intimate partner violence influence the utilization of maternal health services?
Authors: Acharya Devaraj , Adhikari Ramesh , Ranabhat Chhabilal , Paudel Radha , Thapa Purna Bahdur 
Published: June 2019

Abstract
Background

Intimate partner violence [IPV] is public health problem globally and most common in developing countries that affects more than one fourth of women of reproductive age [WRA]. It is more critical during pregnancy. IPV not only affects physical and mental well-being but also leads in birth outcomes with negative consequences.

Methods

We use secondary data from Nepal Demographic and Health Survey 2016 to assess the association between IPV, and maternal service utilization: ANC visits and institutional delivery. Altogether 1374 WRA were randomly selected. Background characteristics of WRA and IPV were the independent variables, and ANC visits and institutional delivery were the dependent variables.

Results

Data show that 26 percent of WRA had faced at least one form of IPV, 68 percent had visited health facilities at least four times for ANC check-up during pregnancy, and the rate of institutional delivery was 61 percent. There were association among IPV with ANC visits and institutional delivery (p<0.001). Age group, educational level, ethnicity, number of child, residence setting, and wealth status of WRA were significantly associated with ANC visits and institutional delivery (p<0.001).

Conclusion

IPV, educational level, and wealth status of WRA were significant predictors for maternal health service utilization. Policy maker should incorporate these significant predictors during planning and intervention as well.
Reporting and synthesis practices in barriers and facilitators reviews: a methodological systematic review
Authors: Bach-Mortensen Anders , Verboom Ben 
Published: June 2019

Abstract
Background: An increasing number of systematic reviews published in high-ranking journals set out to identify and synthesise research on ‘barriers’ to and ‘facilitators’ of the achievement of various outcomes. Yet, this type of review has been criticised for relying on aggregative synthesis approaches (such as ‘vote counting’), and for generating overly simplistic representations of complex social phenomena. While proponents have argued that barriers and facilitators reviews have both explanatory value and the potential to support policy and practice, critics have recommended retiring this genre of review altogether. No review has systematically examined the synthesis practices used in barriers and facilitators reviews, and consequently the factual basis of arguments both for and against these reviews is unclear. We therefore sought to describe and appraise the reporting and synthesis practices used in recently published health-related barriers and facilitators reviews.

Methods: We conducted a methodological systematic review of reviews in accordance with the PRISMA guidelines. A protocol for this review was prospectively registered in PROSPERO (CRD4201811236).

Results: One hundred reviews published over a thirteen-month period were identified. The findings indicate that (1) barriers and facilitators reviews are frequently published, (2) there is a high degree of variation in the synthesis and categorisation practices applied in these reviews, and (3) most reviews neither critically engage with, nor provide a rationale for using, the concepts of barrier and facilitator. While in most cases the barriers and facilitators approach was used without justification or critical discussion by review authors, we identified several common issues across the minority of reviews that included explicit discussion of the approach. These issues tended to be either conceptual/definitional (e.g. ideas about the interrelationships and overlap between factors) or methodological/practical (e.g. challenges related to the aggregation of heterogeneous research).

Conclusion: This review provides a systematic snapshot of the synthesis and reporting practices used in barriers and facilitators reviews. Going forward, we suggest that such reviews would benefit from (1) clearly defining their constructs of analysis, (2) explicitly describing how factors are extracted and subsequently synthesised, and (3) providing critical reflection on the contextual variability and reliability of identified factors.
Compositional Equivalence with Actor Attributes: Positional Analysis of the Florentine Families Network
Authors: Rivero Ostoic J. Antonio 
Published: June 2019

Abstract
This paper extends Compositional Equivalence – which is a structural correspondence type intended for multiplex networks – by incorporating actor attributes in the modeling of the network relational structure as diagonal matrices. As an illustration, we construct the positional system of the Florentine families network with Business and Marriage ties together with relevant characteristics acquired from the actors such as the families’ financial Wealth and the number of Priorates they held. Different representations of the cumulated person hierarchies reveal that adding Wealth to the modeling provides a more accurate picture of what the substantial narrative says about this network.
Legume Cover Crops Reduce Poultry Litter Application Requirements in Organic Systems
Authors: Ackroyd Victoria J. , Cavigelli Michel A. , Spargo John T. , Davis Brian , Garst Grace , Mirsky Steven B. 
Published: June 2019

Organic farmers are challenged by increasing soil P levels resulting from the use of manure to meet cash crop N needs. The use of a legume cover crop may address this challenge. In a 2‐yr study at three organic production sites in Maryland, we examined the combination of a winter annual legume cover crop (hairy vetch, crimson clover, Austrian winter pea, and a no‐cover control) at three poultry litter (PL) application rates (to meet the N requirement of corn, to replace P removed by corn grain harvest, and a no‐PL control). Cover crop biomass varied by site and by year, ranging from about 600 to 6100 kg ha–1 for crimson clover. Cover crop N accumulation ranged from 15 to 169 kg N ha–1. Corn yields, which ranged from 2.9 to 14.2 Mg ha–1, tended to be lowest in the control (0 PL) no‐cover treatments and similar in the N‐based and P‐based treatments irrespective of the cover crop species. These results indicate that when legume cover crops are used, PL can be applied at a P‐replacement rate on sites with a history of PL application to meet crop production and environmental stewardship goals.Core Ideas

Legume cover crop N accumulation ranged from 15 to 169 kg N ha–1.
Corn yield after legume crops was not affected by poultry litter application rate.
Legume cover crops provide opportunity to reduce poultry litter application rates.
Urinary Tract Infection in Children: An Update
Authors: S.M.E Finnell 
Published: June 2019

The 2011 American Academy of Pediatrics (AAP) Urinary Tract Infection (UTI):Clinical Practice Guideline for the Diagnosis and Management of the Initial UTI in Febrile Infants and Children 2-24 Months guideline addressed “areas for research” identifying multiple areas where evidence at the time of the publication was lacking. This review discussed the evidence development in those identified areas. In this paper, I will review the latest literature on UTI in children and focus on those areas of research suggested in these guidelines. I will also summarize the related literature since September 2011.
Literature related to first UTI in children have contributed important new knowledge since the publication of the 2011 AAP guideline; 1) additional research has failed to clarify the relationship between childhood UTI and adult renal function. 2) High grade vesicoureteral reflux (VUR) has been established as a clear risk factor for scarring, but the condition is rare. Abnormal ultrasound, and fever in combination with non-E coli infection are other important predictors of scarring. 3) Antimicrobial prophylaxis appear to decrease UTI recurrences, but a large amount of antibiotics has to be administrated to prevent one UTI and the prevention works best in children with low grade, not high grade, VUR, 4) cranberry juice may prevent UTI, and 5) new, less aggressive guidelines, seem not to have negative consequences for pediatric patients measured as missed true pathology. Future guidelines would benefit from incorporating this new information.
Mobile-Based Technology for the Management of Chronic Diseases in the Elderly: A Feasibility Study
Authors: Shagerdi Ghazal , Ayatollahi Haleh , Oskouie Fatemeh 
Published: June 2019

Introduction:
Population aging and related issues are among the most important challenges
in different countries. It seems that the use of remote technology can provide the elderly
with better healthcare services and can help them to manage chronic diseases. This research aimed
to investigate the experts' views about the feasibility of using mobile-based technology to manage
chronic diseases in the elderly.

Methods:
This was a survey study which was completed in 2018. The participants were the faculty
members of the department of geriatrics across the country (n=33). In order to collect data, two
questionnaires were used. The first questionnaire contained questions related to the five dimensions
of a feasibility study and the second questionnaire consisted of five open questions
about the opportunities, threats, strengths and weaknesses of using mobile-based technology in
chronic disease management. The qualitative data were analyzed by using content analysis
method and the quantitative data were analyzed by using descriptive statistics.

Results:
From the participants’ perspectives, it was feasible to use mobile-based technology in
chronic disease management for elderly people. The mean values for five feasibility dimensions
were as follows: ethico-legal dimension (4.09±1.01), scheduling dimension (3.70±1.03), economic
dimension (3.47±1.04), operational dimension (3.42±1.12) and technical dimension (3.07±1.27).
While such a technology can help increasing the accessibility of healthcare services, raising health
literacy, and saving time and costs, the main threats, namely; the misinterpretation of information
and the possibility of breeching confidentiality should not be underestimated.

Conclusion:
The results showed that mHealth and remote medical technologies can be used for
chronic disease management among elderly people. However, these technologies have some strengths
and weaknesses. In order to succeed in the development and implementation of these projects, it is essential
to consider probable threats and weaknesses before implementing the applications.
Quantitative structure-cytotoxic activity relationship of phenylthiourea derivatives from ChemBL database on sirtuin-1 receptor by in silico
Authors: Nasyanka Anindi Lupita 
Published: June 2019

Rational drug design becomes a necessity amid the development of drugs that are inefficient and time-consuming. Hansch's QSAR helps reduce these shortcomings supported by the role of biocomputation. Some of the roles of biocomputation that can be used include in silico testing and the availability of databases for new drug-receptor and ligand candidates. This study aims to determine the QSAR through the search for the best equations analyzed by ANOVA statistics between cytotoxic activity in silico (Log 1/c) anticancer compounds derived from phenylthiourea stored in the ChemBL database with lipophilic parameters (ALPP and AlogP) , electronic (ACDpKa), and its sterics (PMW). The best equation is obtained Log 1/c = -46,194 - 0,152 PMW- 3,769 ALogP - 1,336 ACDpKa with a value of N = 28; F = 20,866; r = 0,850; P = 0,000; SE = 5.82160. In the future, this equation can be used to find other new phenylthiourea derivatives that have better cytotoxic activity.
Contact Lens Innovations: Spread the Word
Authors: Rosen Chad M 
Published: June 2019

Just as we see changes taking place in the healthcare system, we are also seeing changes take place within the publishing industry. Historically, access to peer-reviewed research and papers has been limited to those who pay membership fees to individual organizations or those working in academic institutions. As healthcare continues to change and universities are increasing the amount evidence-based medicine taught, a larger emphasis is placed on the scientific method and how to evaluate credible research. For those wanting to expand upon their education, access to scientific research can be difficult to obtain. Open-access journals have provided a platform in which individuals can easily stay up-to-date on information in his or her specialty.
Great Leaders Innovate Teamwork
Authors: Purohit Shweta 
Published: June 2019

Wisdom perpetuates the legend of modernism as a private act, a spark of originality imminent, an Aha! Instant in the brain of a mastermind. People in fact favor to consider in the rough individuality of detection, possibly since they hardly ever get to see the sausage-making process behind every get through modernism. Three decades of investigate has obviously exposed that modernism is most often a group attempt. Thomas Edison, for example, is remembered as almost certainly the most American discoverer of the untimely 20th century. From his productive intelligence came the brightest bulb and the turntable, along with additional than a thousand further untested inventions over a sixty-year vocation. However, he only just worked by yourself. As many have experienced, may be Edison’s most donations were his artisan-oriented shops—a new technique of organizing for innovation he shaped that has evolved into today’s R&D laboratory with its team-based move toward.
WordPress: History in Brief and Analysis.
Authors: Tiwari Rajeev 
Published: June 2019

In this article, I share my though over the WordPress. Starting with about to history and end with conclusion. This paper is all about the WordPress ear which is not finished yet.
WordPress is fun. It is easy in use. Even a non-technical person can use this software to make his blog/website. Unlimited resources theme, plug-in, codex, support, etc for users. No dead end with wordpress. You stuck somewhere with something, just search in web you will get help.
So you can understand this, that the developers of wordpress design wordpress with the desire to create a system which is more helpful and productive. Which give user a great experience of working with CMS like wordpress.
ANALYSIS OF EFFECTS OF USING 9/7 WAVELET COEFFICIENTS IN MULTI-RESOLUTION ANALYSIS
Authors: Sharma Manish , Lal Prof. Sonu 
Published: June 2019

Conventional distributed arithmetic (DA) is popular in field programmable gate array (FPGA) design, and it features on-chip ROM to achieve high speed and regularity. In this paper, we describe high speed area efficient 1-D discrete wavelet transform (DWT) using 9/7 filter based new efficient distributed arithmetic (NEDA) Technique. Being area efficient architecture free of ROM, multiplication, and subtraction, NEDA can also expose the redundancy existing in the adder array consisting of entries of 0 and 1. This architecture supports any size of image pixel value and any level of decomposition. The parallel structure has 100% hardware utilization efficiency.
Adaptive Channel Estimation Algorithm For Multi Input Multi Output System – A Brief Review
Authors: Ingle Veena , Patel Arun 
Published: June 2019

Channel estimation plays affective role on the performance of wireless and wire communication systems, since its knowledge is utilized to track and analysis the signal data symbols. Channel estimation is very important technique especially in wireless network systems where the wireless channel change over time, usually caused by transmitter and/or receiver being in motion and/or stable. In order to provide stability and high data receiving rates at the receiver, the system needs an accurate and minimum error estimate of the time-varying channel. Channel estimation is based on the training sequence of bits and which is unique for a certain transmitter and which is repeated in every transmitted burst. The modulated corrupted signal from the channel has to be undergoing the channel estimation using algorithms like Least Mean Squares, Normalized LMS, Variable Step Size LMS, Recursive Least Squares, Least Mean-Squares Newton Algorithm etc are used buffer and estimate the receiver end signal. In this paper a brief reviewing the different channel estimation algorithms for demodulation and comparing all of them with its output performances at various inputs signal and also proposed new algorithm for multi input multi output wireless communication system in noisy and motion environment.
Index Terms— Channel estimation, Multiple Input Multiple Output, Least Mean Squares, Normalized LMS, Variable Step Size LMS, Recursive Least Squares, Least Mean-Squares Newton Algorithm, Mean square error.
A REVIEW - CAPTCHA AS GRAPHICAL PASSWORDS—A NEW SECURITY PRIMITIVE BASED ON HARD AI PROBLEMS
Authors: , PANKAJ 
Published: June 2019

Most of the safety primeval square measure supported mathematical issues. This analysis goals to check existing parole and to style a brand new improved graphical parole pattern. Captcha as a graphical parole. during this paper, we tend to discuss a brand new security primeval supported exhausting computer science issues, a innovative of graphical parole systems created on dominant of Captcha technology, what we are saying Captcha as graphical passwords (CaRP). CaRP is each a Captcha and a graphical parole pattern. With the mix of CAPTCHA and graphical parole addresses a like on-line estimation attacks, relay attacks, combination of with dual-view technology, and shoulder-surfing attacks. If the parole is in search nominative then CaRP parole are often found solely risk by automatic on-line estimation attack.
Optimization of Small Scale Concentrated Solar Power Plant With Revolving Mechanical Arm
Authors: Patel Pushpendra Kumar , Sachdeva Adarsh , Yadav Dharmendra 
Published: June 2019

Electrification ratio in India by the end of 2014 was about 70%. This means that 30% of people/of the group does not have electricity. So I am designing small scale (focused one’s effort/increased/mainly studied) solar power plant with revolving mechanical arm which can be operated in small villages or in that areas were electrification is not possible. Some restrictions of electrification in these areas are the cost of (having different things working together as one unit) grid construction is (compared to other things) high, the limitation of energy useful things/valuable supplies and the population of the area is (compared to other things) small.

A small scale (focused one’s effort/increased/mainly studied) solar power plant with revolving mechanical arm and (related to energy from plants) energy can be a good choice to solve the electricity problem in these areas. This option is based on the (compared to other things) good possible strength of solar energy in some areas of India which is daily average strength is about 3-5 kWh per day. This presents a series of activities in developing a (focused one’s effort/increased/mainly studied) solar power plant which includes the idea-based design of the small-scale system with the ability (to hold or do something) of 10kW.

This project focused on the design & analysis of a small scale concentrated solar plant and revolving mechanical arm at solar receiver for integration into this planned solar unit. Mean irradiance levels at the focal spot of the solar receiver of 3 – 5 kWh per day and peak levels of 14 kWh per day were identified as major design challenges.
EXPLOITATION OF PLANT EXTRACTS (STEM AND ROOT) OF MICROPROPAGATED BACOPA MONNIERI : ANTIMYCOTIC POTENTIAL
Authors: NARWAL MRRIDULA DANGI 
Published: June 2019

Bacopa monnieri is commonly called as brahmi or jal brahmi in India. Brahmi is a non-aromatic herb Brahmi is considered as the herb played a very important role in Ayurvedic medicine. It is found easily India, Australia, Europe, Africa, Asia. Bacopa monnieri (L) belongs to the family Scrophulariaceae is an amphibious plant of tropical and normally found growing on the banks of the rivers and lakes. It is commonly called as brahmi or jal brahmi in India. Brahmi is considered as the main rejuvenating herb played a very important role in Ayurvedic therapies. It also has anti-inflammatory, analgesic, antipyretic, epilepsy, anticancer, antioxidant activities and recently antimycotic preoperty has been reported. The micro propagation protocol of the medicinally important plant Bacopa monnieri was standardized using nodal segments as explants. They were surface sterilized with HgCl2 (0.1%) for 3 minutes prior to inoculation on MS media supplemented with BAP (0.5- 2.5 mg/l); IAA (0.1-0.5 mg/l for shooting,1.0-1.5 mg/l for rooting); NAA (0.1- 0.5 mg/l for shooting, 1.0-1.5 mg/l for rooting). The best performance for shoot multiplication was showed in MS medium supplemented with 1.5 mg/l BAP + 0.5 mg/l IAA. In this combination the number of shoots per explant was 16 and average length of shoot 5.54 ± 0.54 cm. But when different concentrations of NAA were applied along with 1.5 mg/l BAP the number of shoots per explant was 14 and average shoot length was 3.46 ± 0.43 on media. For root induction, best rooting was observed with half strength of MS medium supplemented with IAA (1.0 mg/l). In this combination, it was observed that the number of roots was 12 and average root length of 2.80 ± 0.09. The present study is a stepping stone for in vitro production of required active principles of Bacopa monnieri.