bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammatory Pouch Conditions Are Common After Ileal Pouch Anal Anastomosis in Ulcerative Colitis Patients
Authors: Kayal Maia , Plietz Michael , Rizvi Anam , Radcliffe Marlana , Riggs Alexa , Yzet Clara , Tixier Emily , Trivedi Parth , Ungaro Ryan C , Khaitov Sergey , Sylla Patricia , Greenstein Alexander , Frederic Colombel Jean , Dubinsky Marla C 
Published: October 2019

Abstract

Background
Total proctocolectomy (TPC) with ileal pouch anal anastomosis (IPAA) is the gold standard surgery for ulcerative colitis (UC) patients with medically refractory disease. The aim of this study was to report the rates and risk factors of inflammatory pouch conditions.

Methods
This was a retrospective review of UC or IBD unspecified (IBDU) patients who underwent TPC with IPAA for refractory disease or dysplasia between 2008 and 2017. Pouchoscopy data were used to calculate rates of inflammatory pouch conditions. Factors associated with outcomes in univariable analysis were investigated in multivariable analysis.

Results
Of the 621 patients more than 18 years of age who underwent TPC with IPAA between January 2008 and December 2017, pouchoscopy data were available for 386 patients during a median follow-up period of 4 years. Acute pouchitis occurred in 205 patients (53%), 60 of whom (30%) progressed to chronic pouchitis. Cuffitis and Crohn's disease–like condition (CDLC) of the pouch occurred in 119 (30%) patients and 46 (12%) patients, respectively. In multivariable analysis, female sex was associated with a decreased risk of acute pouchitis, and pre-operative steroid use and medically refractory disease were associated with an increased risk; IBDU was associated with chronic pouchitis; rectal cuff length ≥2 cm and medically refractory disease were associated with cuffitis; age 45–54 at colectomy was associated with CDLC. Rates of pouch failure were similar in chronic pouchitis and CDLC patients treated with biologics and those who were not.

Conclusions
Inflammatory pouch conditions are common. Biologic use for chronic pouchitis and CDLC does not impact the rate of pouch failure.
Ensemble modelling in descriptive epidemiology: burden of disease estimation
Authors: Bannick Marlena S , McGaughey Madeline , Flaxman Abraham D 
Published: October 2019

Abstract
Ensemble modelling is a quantitative method that combines information from multiple individual models and has shown great promise in statistical machine learning. Ensemble models have a theoretical claim to being models that make the ‘best’ predictions possible. Applications of ensemble models to health research have included applying ensemble models like the super learner and random forests to epidemiological prediction tasks. Recently, ensemble methods have been applied successfully in burden of disease estimation. This article aims to provide epidemiologists with a practical understanding of the mechanisms of an ensemble model and insight into constructing ensemble models that are grounded in the epidemiological dynamics of the prediction problem of interest. We summarize the history of ensemble models, present a user-friendly framework for conceptualizing and constructing ensemble models, walk the reader through a tutorial of applying the framework to an application in burden of disease estimation, and discuss further applications.
Behavior of unconfined and CFRP confined rubberized concrete
Authors: Tufail Rana Faisal , Feng Xiong , Zahid Muhammad 
Published: October 2019

AbstractThe use of rubberized concrete (RuC) is an effective environmental approach to reduce the amount of scrap tires around the world. However, there are serious concerns regarding the compressive strength of RuC. This article investigates the use of externally bonded carbon fiber reinforced polymer (CFRP) jackets on RuC to develop a novel high strength and deformable CFRP confined RuC. In this study, 66 RuC cylinders were cast with 0, 10, 20, 30, 40 and 50% fine or coarse rubber to replace mineral aggregates. The RuC cylinders were then confined with one, two or three layers of CFRP jackets. The results indicated 208% high lateral strains in unconfined RuC as compared to the conventional concrete. CFRP jacketing was highly effective for enhancing the compressive strength and deformation capacity of RuC, where high compressive strength enhancement of 52 MPa and deformation capacity (317% axial strain) was achieved. The confined compressive strength test results were compared with the strength models to assess their validity for CFRP confined RuC. An analysis-oriented strength model was developed to predict the axial compressive strength of RuC confined by CFRP jackets. Overall, this study demonstrated the potential of using CFRP-confined RuC as a new structural material with improved strength and deformation.
Amino acid composition and digestible amino acid content in animal protein by-product meals fed to growing pigs1
Authors: Kerr Brian J , Urriola Pedro E , Jha Rajesh , Thomson John E , Curry Shelby M , Shurson Gerald C 
Published: October 2019

Abstract
An industry survey and animal experiment were conducted to evaluate the amino acid (AA) compositional variability and standardized ileal digestibility (SID) of AA in animal protein by-products fed to growing pigs. Animal protein by-product meals (212) were categorized into 8 groupings (blood meal, chicken by-product meal, chicken meal, feather meal, meat and bone meal, meat meal, poultry by-product meal, and poultry meal) and analyzed for total AA. Amino acid analysis among (e.g., Lys in blood meal averaged 9.20% compared with 2.31% for feather meal, DM basis) and within (e.g., Lys range of 1.54% in blood meal and 1.44% in feather meal, DM basis) the by-product classifications varied as expected, but on average the total AA values were similar to that reported in the literature. For the determination of the SID of AA, 15 barrows (average initial and final BW of 31.6 and 78.7 kg, respectively) were fitted with a T-cannula in the distal ileum and allotted to 15 diets over nine 7-d periods, resulting in 9 replications per diet. Pigs were fed a basal diet based on soybean meal and dehulled-degermed corn, 13 diets containing 17.5% animal protein by-product meal to partially replace a portion of the soybean meal and dehulled-degermed corn in the basal diet, or a N-free diet. Pigs were re-allotted to diets based on minimizing the number to times that the N-free diet would precede or follow feeding either of the blood or feather meal diets because of concern with inadequate diet consumption, as well as to prevent diets from being re-fed to the same pig during the next or subsequent periods. Values for the apparent ileal AA digestibility of each diet were determined, adjusted to SID based upon the endogenous AA losses determined by feeding the N-free diet, and the SID of AA in each animal protein by-product meal calculated using the difference procedure. The SID of AA varied among (e.g., SID of Lys averaged 91% in chicken meal but 47% in feather meal) and within (e.g., SID of Lys in three meat and bone meals was 80%, 71%, and 54%) the animal protein by-product meals, as would be expected and are consistent with variation reported in the literature. Overall, the data provide total AA composition for 212 samples and SID of AA for 13 samples of animal protein by-product meals, including data on their variability, which is critical for their use in feed formulation programs.
Feed efficiency and carcass metrics in growing cattle1
Authors: Kelly David N , Murphy Craig , Sleator Roy D , Judge Michelle M , Conroy Stephen B , Berry Donagh P 
Published: October 2019

Abstract
Some definitions of feed efficiency such as residual energy intake (REI) and residual gain (RG) may not truly reflect production efficiency. The energy sinks used in the derivation of the traits include metabolic live-weight; producers finishing cattle for slaughter are, however, paid on the basis of carcass weight, as opposed to live-weight. The objective of the present study was to explore alternative definitions of REI and RG which are more reflective of production efficiency, and quantify their relationship with performance, ultrasound, and carcass traits across multiple breeds and sexes of cattle. Feed intake and live-weight records were available on 5,172 growing animals, 2,187 of which also had information relating to carcass traits; all animals were fed a concentrate-based diet representative of a feedlot diet. Animal linear mixed models were used to estimate (co)variance components. Heritability estimates for all derived REI traits varied from 0.36 (REICWF; REI using carcass weight and carcass fat as energy sinks) to 0.50 (traditional REI derived with the energy sinks of both live-weight and ADG). The heritability for the RG traits varied from 0.24 to 0.34. Phenotypic correlations among all definitions of the REI traits ranged from 0.90 (REI with REICWF) to 0.99 (traditional REI with REI using metabolic preslaughter live-weight and ADG). All were different (P < 0.001) from one suggesting reranking of animals when using different definitions of REI to identify efficient cattle. The derived RG traits were either weakly or not correlated (P > 0.05) with the ultrasound and carcass traits. Genetic correlations between the REI traits with carcass weight, dressing difference (i.e., live-weight immediately preslaughter minus carcass weight) and dressing percentage (i.e., carcass weight divided by live-weight immediately preslaughter) implies that selection on any of the REI traits will increase carcass weight, lower the dressing difference and increase dressing percentage. Selection on REICW (REI using carcass weight as an energy sink), as opposed to traditional REI, should increase the carcass weight 2.2 times slower but reduce the dressing difference 4.3 times faster. While traditionally defined REI is informative from a research perspective, the ability to convert energy into live-weight gain does not necessarily equate to carcass gain, and as such, traits such as REICW and REICWF provide a better description of production efficiency for feedlot cattle.
Gill fouling in the economically important freshwater shrimp Macrobrachium rosenbergii (De Man, 1879) (Caridea: Palaemonidae)
Authors: Wortham Jen L , VanMaurik Lauren 
Published: October 2019

Abstract
The giant freshwater prawn, Macrobrachium rosenbergii (De Man, 1879), lives in freshwater environments of the Indo-West Pacific region and is commonly farmed. Males transition into three male morphotypes that differ in behavior and morphology. Small-clawed males (SM) molt into orange-clawed males (OC) that molt into the harvested and largest blue-clawed males (BC). Grooming behaviors can remove fouling such as sediment particles, bacteria, and other organisms, all of which are commonly found in the natural environment as well as in aquaculture environments. Because individuals of this species groom their bodies frequently, especially the gills, the objective of the study was to observe gills of male morphotypes and females and evaluate their fouling levels and types using light microscopy, bacterial counts, and scanning electron microscopy. The male morphotypes and females are fouled differently, with grooming behaviors being effective in removing sedimentary and bacterial fouling from the gills. Although their relative efficiencies in removing fouling materials from the gills were not statistically significant, OC and BC exhibited contrasting gill fouling patterns with higher bacterial than sedimentary fouling in the former but the opposite in the latter. This difference may be attributed to differential levels of fouling related to variation in behavioral priorities, grooming behaviors, and morphology. Control of bacterial and sedimentary fouling in aquaculture could have large implications on the quality and survival of harvested individuals.
Carbon Dioxide Fumigation to Shorten Cold Disinfestation Treatments for Thaumatotibia leucotreta (Lepidoptera: Tortricidae) in Citrus Fruit
Authors: Grout Tim G , Stoltz Kim C 
Published: October 2019

AbstractAlthough elevated levels of carbon dioxide have been used in controlled atmosphere treatments with low oxygen levels for a number of deciduous crops, the use of much higher concentrations of carbon dioxide followed by a short cold treatment for citrus was only suggested as a viable option for disinfestation in 2005. Carbon dioxide alone, for a period of 24 h at concentrations up to 70% in air caused variable levels of mortality of Thaumatotibia leucotreta (Meyrick) larvae in citrus, but never completely controlled this pest. The susceptibility to carbon dioxide appeared to vary more with the batch of T. leucotreta eggs than with different citrus cultivars. By following CO2 fumigation with a short cold treatment, complete control of this pest was achieved and the results with sequential treatments were more consistent. The efficacy of the combined treatment was reduced when it took ≥12 h to move fruit after fumigation into a cold room at 2°C, or if the temperature was not reduced below 12°C within 24 h after fumigation. In these cases, the benefit of the short cold treatment was lost and mortality was similar to CO2 fumigation alone. These results hold promise for the development of a shorter commercial treatment to meet quarantine restrictions against this pest in citrus.
Increased Suitability of Poleward Climate for a Tropical Butterfly (Euripus nyctelius) (Lepidoptera: Nymphalidae) Accompanies its Successful Range Expansion
Authors: Au Tsun Fung , Bonebrake Timothy C 
Published: October 2019

Abstract
Distribution shifts are a common response in butterflies to a warming climate. Hong Kong has documented records of several new butterfly species in recent decades, comprising a high proportion of tropical species, some of which have successfully established. In this study, we examined possible drivers for the establishment of Euripus nyctelius Doubleday (Lepidoptera: Nymphalidae) by studying its thermal physiology and modeling current climate and future distributions projected by species distribution modeling (SDM). We found that E. nyctelius adults have a significantly higher critical thermal minimum than its local temperate relative, Hestina assimilis Linnaeus (Lepidoptera: Nymphalidae), suggesting a possible physiological constraint that may have been lifted with recent warming. SDMs provide further evidence that a shifting climate envelope may have improved the climate suitability for E. nyctelius in Hong Kong and South China—however, we cannot rule out the role of other drivers potentially influencing or driving range expansion, habitat change in particular. Conclusive attribution of warming-driven impacts for most tropical species is difficult or not possible due to a lack of historical or long-term data. Tropical insects will require a significant advancement in efforts to monitor species and populations across countries if we are to conclusively document climate-driven shifts in species distributions and manage the consequences of such species redistribution. Nevertheless, the warming climate and subsequent increased climatic suitability for tropical species in poleward areas, as shown here, is likely to result in future species redistribution events in subtropical and temperate ecosystems.
NSD3S stabilizes MYC through hindering its interaction with FBXW7
Authors: Gonzalez-Pecchi Valentina , Kwan Albert K , Doyle Sean , Ivanov Andrey A , Du Yuhong , Fu Haian 
Published: October 2019

Abstract
The MYC transcription factor plays a key role in cell growth control. Enhanced MYC protein stability has been found to promote tumorigenesis. Thus, understanding how MYC stability is controlled may have significant implications for revealing MYC-driven growth regulatory mechanisms in physiological and pathological processes. Our previous work identified the histone lysine methyltransferase nuclear receptor binding SET domain protein 3 (NSD3) as a MYC modulator. NSD3S, a noncatalytic isoform of NSD3 with oncogenic activity, appears to bind, stabilize, and activate the transcriptional activity of MYC. However, the mechanism by which NSD3S stabilizes MYC remains to be elucidated. To uncover the nature of the interaction and the underlying mechanism of MYC regulation by NSD3S, we characterized the binding interface between both proteins by narrowing the interface to a 15-amino acid region in NSD3S that is partially required for MYC regulation. Mechanistically, NSD3S binds to MYC and reduces the association of F-box and WD repeat domain containing 7 (FBXW7) with MYC, which results in suppression of FBXW7-mediated proteasomal degradation of MYC and an increase in MYC protein half-life. These results support a critical role for NSD3S in the regulation of MYC function and provide a novel mechanism for NSD3S oncogenic function through inhibition of FBXW7-mediated degradation of MYC.
Treating or Killing? The Divergent Moral Implications of Cardiac Device Deactivation
Authors: Pilkington Bryan C 
Published: October 2019

Abstract
In this article, I argue that there is a moral difference between deactivating an implantable cardioverter defibrillator (ICD) and turning off a cardiac pacemaker (CP). It is, at least in most cases, morally permissible to deactivate an ICD. It is not, at least in most cases, morally permissible to turn off a pacemaker in a fully or significantly pacemaker-dependent patient. After describing the relevant medical technologies—pacemakers and ICDs—I continue with contrasting perspectives on the issue of deactivation from practitioners involved with these devices: physicians, nurses, and allied professionals. Next, I offer a few possible analyses of the situation, relying on recent work in medical ethics. Considerations of intention, responsibility, and replacement support my distinguishing between ICDs and CPs. I conclude by recommending a change in policy of one of the leading cardiac societies.
Topical Review: A Biopsychosocial Framework for Pediatric Narcolepsy and Idiopathic Hypersomnia
Authors: Graef Danielle M , Byars Kelly C , Simakajornboon Narong , Dye Thomas J 
Published: October 2019

AbstractObjectiveProvide an overview of current research findings in pediatric central disorders of hypersomnolence (CDH) and propose a biopsychosocial model for clinical management, with a focus on interdisciplinary care and future directions for research and clinical practice.MethodsLiterature review drawing from pediatric and adult narcolepsy, as well as pediatric sleep and chronic pain research to develop an integrative biopsychosocial model for pediatric CDH.ResultsYouth with CDH are vulnerable to impairments in academics, emotional, and behavioral functioning, activity engagement and quality of life (QOL). There is a complex interrelationship between neurobiological features of disease, treatment-related factors, and psychological, sleep-related, and contextual factors across development. Research is limited largely to adults and pediatric narcolepsy type 1 and the mechanisms and evolution of morbidity remain poorly understood.ConclusionsIn addition to first-line treatment (pharmacotherapy), routine screening of bio-behavioral and psychosocial functioning and QOL is needed to identify risk for compromised functioning warranting adjunctive interventions with behavioral health specialists.
An Investment in the Future: Institutional Aspects of Credential Recognition of Refugees in Germany
Authors: Jacobsen Jannes 
Published: October 2019

Abstract
Adding to the rich literature on the economic integration of refugees, this article extends the scope towards the role of institutions by focusing on the transfer of human capital by means of credential recognition. The 2012 Federal Act of Recognition in Germany is a new institution that provides the possibility to study the transfer of human capital in depth. I argue that analysing the decision for recognition of credentials is an important aspect of economic integration because it mirrors an investment in future labour-market access. I hypothesize that institutions, such as integration and language classes and the refugee status by admission, are key for explaining who tries to obtain official recognition for their credentials. In order to test my hypothesis, I employ panel data from the IAB-BAMF-SOEP Survey of Refugees in Germany. Results show that both a secure residence title and participation in language/integration classes lead to a higher likelihood of applying for the recognition of degrees.
Spinal extradural arachnoid cyst in a child—a case report
Authors: Oyemolade Toyin A , Adeolu Augustine A , Idowu Olusola K 
Published: October 2019

ABSTRACT
Extradural spinal arachnoid cysts are rare lesions. They frequently communicate with the subarachnoid space through a defect in the dura. Symptoms result from compression of the spinal cord or nerve roots. The treatment of choice is complete surgical excision. We report the case of a 12-year-old girl with extradural spinal arachnoid cyst who had complete surgical excision with good outcome.
Inguinal hernia with complete urinary bladder herniation: a case report and review of the literature
Authors: Papatheofani Vasiliki , Beaumont Katharina , Nuessler Natascha C 
Published: October 2019

Abstract
Although inguinal hernias are common, inguinal herniation of the urinary bladder wall is rare. Moreover, the complete migration of the urinary bladder into the scrotum is considered less frequent. The majority of patients with bladder hernias are asymptomatic and diagnosis is made intraoperatively; however, difficulties in urination may lead to the correct diagnosis. We report about a case of a large right-sided scrotal hernia with complete bladder herniation presenting without urological symptoms.
A Review of Conceptual Approaches and Empirical Evidence on Probability and Nonprobability Sample Survey Research
Authors: Cornesse Carina , Blom Annelies G , Dutwin David , Krosnick Jon A , De Leeuw Edith D , Legleye Stéphane , Pasek Josh , Pennay Darren , Phillips Benjamin , Sakshaug Joseph W , Struminskaya Bella , Wenz Alexander 
Published: October 2019

Abstract
There is an ongoing debate in the survey research literature about whether and when probability and nonprobability sample surveys produce accurate estimates of a larger population. Statistical theory provides a justification for confidence in probability sampling as a function of the survey design, whereas inferences based on nonprobability sampling are entirely dependent on models for validity. This article reviews the current debate about probability and nonprobability sample surveys. We describe the conditions under which nonprobability sample surveys may provide accurate results in theory and discuss empirical evidence on which types of samples produce the highest accuracy in practice. From these theoretical and empirical considerations, we derive best-practice recommendations and outline paths for future research.
Optical continuum photometric reverberation mapping of the Seyfert-1 galaxy Mrk509
Authors: Nuñez F Pozo , Gianniotis N , Blex J , Lisow T , Chini R , Polsterer K L , Pott J-U , Esser J , Pietrzyński G 
Published: October 2019

Abstract
We present the results of a two year optical continuum photometric reverberation mapping campaign carried out on the nucleus of the Seyfert-1 galaxy Mrk509. Specially designed narrow-band filters were used in order to mitigate the line and pseudo-continuum contamination of the signal from the broad line region, while allowing for high-accuracy flux-calibration over a large field of view. We obtained light curves with a sub-day time sampling and typical flux uncertainties of 1%. The high photometric precision allowed us to measure inter-band continuum time delays of up to ∼2 days across the optical range. The time delays are consistent with the relation τ∝λ4/3 predicted for an optically thick and geometrically thin accretion disk model. The size of the disk is, however, a factor of 1.8 larger than predictions based on the standard thin-disk theory. We argue that, for the particular case of Mrk509, a larger black hole mass due to the unknown geometry scaling factor can reconcile the difference between the observations and theory.