bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal hyperthermic intraperitoneal chemotherapy regimen for advanced and peritoneal metastatic gastric cancer: a systematic review and Bayesian network meta-analysis
Authors: Wang Tianqi , Ma Shengjie , Zhang Shiwei , Aizezi Yilihaer , Wang Quan 
Published: November 2024

BackgroundPeritoneal metastasis is one of the most common modes of spread of gastric cancer. Currently, surgical treatment combined with hyperthermic intraperitoneal chemotherapy (HIPEC) and systemic chemotherapy has demonstrated promising outcomes in both the treatment and prevention of peritoneal metastasis in gastric cancer. However, various HIPEC drug regimens are in clinical use, and their efficacy remains unclear. This study aims to evaluate the effectiveness of different HIPEC drug regimens in patients with advanced gastric cancer to determine the optimal therapeutic approach.MethodsThis study conducted a systematic review and Bayesian network meta-analysis. Patients in the experimental group underwent surgery combined with HIPEC and chemotherapy. The search period covered literature from database inception to June 1, 2024. Hazard ratios (HRs) with 95% confidence intervals (CIs) were used to evaluate overall survival (OS) as the primary outcome. Odds ratios (ORs) with 95% CIs were used to assess overall disease recurrence, peritoneal recurrence, and postoperative morbidity as secondary outcomes. To ensure scientific rigor and transparency, this study has been registered with PROSPERO (CRD42024533948).ResultsA total of 11 randomized controlled trials (RCTs) involving 1092 patients were included. Compared to surgery combined with chemotherapy, the regimens of cisplatin (HRs = 0.52, 95% CI: 0.38-0.73), mitomycin C (HRs = 0.99, 95% CI: 0.55-1.79), cisplatin plus fluorouracil (HRs = 0.60, 95% CI: 0.38-0.95), and oxaliplatin plus 5-fluorouracil (HRs = 0.53, 95% CI: 0.36-0.78) all demonstrated benefits in OS. The cisplatin (ORs = 0.16, 95% CI: 0.03-0.60) and mitomycin C (ORs = 0.03, 95% CI: 0-0.71) regimens also showed advantages in reducing peritoneal recurrence, with no impact on postoperative morbidity. Importantly, the cisplatin regimen was superior to other regimens in terms of OS and overall disease recurrence, achieving a balance between efficacy and safety.ConclusionsCompared to chemotherapy alone, HIPEC treatment shows significant benefits in OS without a notable disadvantage in postoperative morbidity. Although no single HIPEC regimen demonstrated clear benefits across all outcomes, the cisplatin regimen performed well in multiple aspects, indicating its potential for further research and clinical application.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=533948, identifier CRD42024533948.
Bone marrow mesenchymal stem cell-derived exosomes improve cancer drug delivery in human cell lines and a mouse osteosarcoma model
Authors: Cai Wenquan , He Dawei 
Published: November 2024

IntroductionOsteosarcoma is the most common primary bone tumor. Patients require chemotherapy drugs with high-targeting ability and low off-target toxicity to improve their survival. Exosomes are biological vesicles that mediate long-distance communication between cells and naturally target their source sites. Exosomes derived from bone marrow mesenchymal stem cells (BMSCs) naturally target bone tumor sites, suggesting their potential as effective anti-tumor therapy vectors. In this study, we evaluated the potential of BMSC-derived exosomes in targeting osteosarcoma and serving as a carrier for doxorubicin (DOX).MethodsWe isolated exosomes from human BMSCs and synthesized hybrid exosomes (HEs) by fusing these exosomes with liposomes. These HEs were loaded with DOX to produce a novel drug, HE/DOX.ResultsWe confirmed the successful synthesis of HE/DOX using fluorescence spectroscopy and estimated its size to be 151.1 ± 10.2 nm. HEs expressed the known exosomal proteins ALIX, CD63, and TSG101. Under acidic conditions similar to those observed in the tumor microenvironment, the drug release from HE/DOX was enhanced. In osteosarcoma cell lines and in a mouse osteosarcoma model, HE/DOX exhibited stronger tumor-inhibitory effects than free DOX.ConclusionsOur study demonstrates that BMSC-derived exosomes could effectively target osteosarcoma. Furthermore, HEs can serve as effective carriers of DOX, enabling the treatment of osteosarcoma. These findings highlight a promising direction for tumor-targeted therapy.
Meta-analysis of the effects of different exercise modes on cardiac function and peak oxygen uptake in patients with type 2 diabetes mellitus
Authors: Jianghua He , Feier Ma , Dong Zhu , Qiuying Li , Ya Wen , Yan Wang 
Published: November 2024

BackgroundThe benefits of exercise for primary and secondary prevention of cardiovascular events have been reported in patients with type 2 diabetes mellitus (T2DM). However, the effects of exercise on cardiac structure and function require clarification.MethodsA literature search for clinical studies reporting on the effects of exercise on cardiac structure, cardiac function, and VO2peak in T2DM patients was conducted. PubMed, Embase, EBSCO, Web of Science, and China National Knowledge Infrastructure were systematically searched for original articles published from January 2000 to July 2023. The effect size was expressed as the mean difference (MD) or standardized mean difference (SMD) and its 95% confidence interval (CI). Subgroup analyses were performed by exercise mode (high-intensity interval training [HIIT] or moderate-intensity continuous training [MICT]) and intervention duration (&gt;6 or ≤6 months).ResultsCompared to usual care, both HIIT and MICT significantly affected left ventricular end-diastolic volume (MD: 19.44, 95% CI: 13.72 to 25.17, p &lt; 0.00001; I2 = 42%; MD: 13.90, 95% CI: 7.64 to 20.16, p &lt; 0.0001; I2 = 0%), but only HIIT significantly affected left ventricular mass (MD: 17.04 g, 95% CI: 5.45 to 28.62, p = 0.004; I2 = 0%). HIIT significantly improved left ventricular ejection fraction (MD: 5.52, 95% CI: 2.31 to 8.73, p = 0.0008; I2 = 0%), as did MICT in the ≤6 months subgroup (MD: 1.36, 95% CI: 0.61 to 2.10, p = 0.0004; I2 = 0%). Neither significantly affected systolic tissue velocity. HIIT significantly improved VO2peak (MD: 8.04, 95% CI: 6.26 to 9.83, p &lt; 0.00001; I2 = 0%), as did MICT in the ≤6 months subgroup (MD: 3.33, 95% CI: 2.39 to 4.27, p &lt; 0.00001; I2 = 0%).ConclusionExercise significantly improved cardiac structure, systolic function, and VO2peak, but did not significantly affect diastolic function in T2DM patients. HIIT seemed to be superior to MICT at improving VO2peak and left ventricular ejection fraction in T2DM patients.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/, PROSPERO registration no.: CRD4242018087376
Psychometric evaluation of the Persian version of the Rosenberg Self-Esteem Scale among medical sciences students
Authors: Abbasi Ali , Moradkhani Ahmadreza , Shahri Bahar , Khosravi Hamed , Sohrabi Atena , Mirhosseini Seyedmohammad 
Published: November 2024

IntroductionThe present research carried out to assess the psychometric properties of the Persian version of the Rosenberg Self-Esteem Scale (RSES) among medical sciences students.MethodsThis methodological study took place at Shahroud and Semnan Universities of Medical Sciences in Iran. A sample of 380 medical sciences students was selected through convenience sampling. The study assessed face and content validity, and maximum likelihood explanatory factor analysis (MLEFA) was performed. To evaluate the proposed model by MLEFA, confirmatory factor analysis was carried out. Reliability was examined using Cronbach’s alpha coefficient, McDonald’s omega, and the intra-class correlation coefficient.ResultsThe students had an average age of 22.49 ± 2.72 years. The maximum likelihood explanatory factor analysis (MLEFA) divided the RSES into two components: positive self-esteem and negative self-esteem, which together explained 50.7% of the total variance. Confirmatory factor analysis showed that the model fit the observed data well. The resulting subscales exhibited high internal consistency and stability.ConclusionThe findings of the current study indicate that the Persian version of the Rosenberg Self-Esteem Scale possesses acceptable validity and reliability among Iranian medical sciences students.
Depression and the risk of fibromyalgia syndrome: a two-sample Mendelian randomization study
Authors: Ma Xiaoshan , Sun Jing , Geng Ren , Zhao Yao , Xu Wanzhen , Jiang Yining , Zhao Liyan , Li Yunqian 
Published: November 2024

BackgroundFibromyalgia (FM) is a common illness with a wide range of symptoms, mainly manifested by unexplained chronic systemic musculoskeletal pain, sleep disorders and fatigue, sometimes accompanied by cognitive impairment, psychiatric symptoms and autonomic dysfunction. Previous studies have indicated a correlation between depression and the risk of FM; however, it remains uncertain whether this association reflects a causal relationship.MethodsWe evaluated the etiological association between the genetically predicted depression and the risk of developing FM by conducting a two-sample Mendelian Randomization (MR) study. The data on single nucleotide polymorphisms (SNPs) related to depression were obtained from the UK Biobank (UKB) and the Psychiatric Genomics Consortium (PGC) of White British European ancestry, and the data for FM were from the 5th release of the FinnGen study. We adopted the Inverse Variance Weighted (IVW) approach as the principal standard. In order to detect the existence of horizontal pleiotropy and heterogeneity, we adopted the MR-Egger approach as the sensitivity analysis.ResultsIn our MR analysis, 42 depression-related variants were identified as valid instrumental variables (IVs). The IVW approach’s results manifest that there is no etiologic causality between genetically predicted depression and the risk of FM (odds ratio [OR]: 1.673, 95% confidence interval [CI]: 0.852—3.287, P = 0.135). The study did not find any significant heterogeneities or horizontal pleiotropies (P &gt; 0.05).ConclusionsOur results suggest that there is no significant genetic evidence linking depression to an increased risk of FM. However, further research is necessary to investigate the potential relationship and underlying mechanisms between depression and the risk of FM.
Factors associated with loneliness in Latin-American family care partners during the COVID-19 pandemic
Authors: Leon Tomas , Tapia-Munoz Thamara , Slachevsky Andrea , Beber Bárbara Costa , Aguzzoli Fernando , Nubia Carla , Vilar-Compte Mireya , Gaitan-Rossi Pablo , Olavarria Loreto , Castro Loreto , Pinto Alejandra , Guajardo Tania , Grycuk R. Emilia , Chen Yaohua , Leroi Iracema , Lawlor Brian , Duran-Aniotz Claudia , O’ Sullivan Roger , Miranda-Castillo Claudia 
Published: November 2024

BackgroundCOVID-19-related restrictions led to an increase in overall loneliness and social isolation. Before the pandemic, care partners reported higher levels of loneliness and higher loneliness prevalence compared to non-care partners. Because of the spread and severity of the infections, and the access to support spread, we expect a different impact of the COVID-19 pandemic on LATAM care partners.ObjectivesTo describe the loneliness levels of LATAM caregivers and to identify socioeconomic and health factors associated.DesignAn international online cross-sectional survey for care partners, embedded within the ‘Coping with Loneliness and Isolation during COVID-19’ (CLIC) Study conducted between June 2020– and November 2020.SettingWe analysed data from 246 family care partners living in Latin American countries (46% Mexico, 26% Chile,18% Brazil, and 10% from Argentina, Peru, Venezuela, Panama, Guatemala y Costa Rica).MeasurementsWe assessed loneliness using the 6-items of De Jong Gierveld loneliness Scale. We described the levels of overall, emotional, and social loneliness pre and during Covid, and reported the distribution of care partners who improved, worsened or maintained their levels of loneliness. Moreover, we used longitudinal multiple linear regression models with bootstraps errors of 1,000 iterations to identify factors associated with the levels of overall, emotional, and social loneliness during the pandemic.ResultsParticipants were mostly women, 50 years and older, in a partnership, highly educated and with finances meeting their needs, with good to excellent physical and mental health. Among the total of care partners, 55% perceived higher overall loneliness, 56% higher emotional loneliness, and 21% higher social loneliness during the pandemic in comparison with pre-COVID-19 levels. Perceived mental health was associated with the overall, emotional, and social loneliness.ConclusionsRegardless of their living and health situation, during the pandemic, loneliness increased in all groups of care partners. These should be taken in consideration when planning public health approaches for crises such as pandemics or other large-scale disruptive events.
Relationship between Chinese college students’ attitude to physical exercise and psychological capital: the mediating effects of self-control and gender
Authors: Li Xinnan , Cui Lei , Shen Qi-Qi , Luo Rui , Liu Min 
Published: November 2024

ObjectiveThis study aimed to explore the impact of attitudes toward physical exercise on college students’ psychological capital and its mechanism of action, providing new pathways and scientific evidence for enhancing psychological capital among college students.MethodsA total of 519 college students (mean age: 19.95 ± 1.34) were surveyed using a questionnaire.Results(1) Attitudes toward physical exercise have a significant direct predictive effect on college students’ psychological capital; (2) Attitudes toward physical exercise can indirectly predict psychological capital through the mediating role of self-control; (3) The influence of attitudes toward physical exercise on self-control is moderated by gender, with a greater impact on female college students than on male students.Conclusion(1) This study investigated the mechanism by which attitudes toward physical exercise influence psychological capital through self-control and gender differences; (2) The study revealed the positive role of psychological capital, with a significant predictive effect of attitudes toward physical exercise on college students’ psychological capital (B = 0.46, p &lt; 0.001), and identified the reasons for gender differences, with attitudes toward physical exercise having a stronger promoting effect on self-control in female college students (B = 0.26, t = 3.80, p &lt; 0.001). It provides guiding suggestions for enhancing psychological capital by fostering attitudes toward physical exercise among college students.
Construction of women's empowerment index for Bangladesh
Authors: Chowdhury Shanjida , Khan Md. Mehedi Hasan , Haque Md. Aminul 
Published: November 2024

IntroductionThis study is dedicated to refining and enhancing the measurement model of women's empowerment in Bangladesh. Women's empowerment, a crucial and multifaceted aspect of societal growth, is often hindered by gender disparities. This is particularly evident in societies like Bangladesh, where women face inequalities in education, economic opportunities, and decision-making power. To address these disparities effectively, it is essential to have a comprehensive understanding of women's empowerment. Therefore, this study aims to refine and enhance the measurement model to capture the multifaceted nature of women's empowerment accurately.MethodsTo gather data for this study, a structured questionnaire was administered to married women of reproductive age (15–49) in eight Mouza/Mohalla in Dhaka, Bangladesh. This unique approach allowed us to capture a diverse range of perspectives. We used thirty-three indicators across economic, socio-cultural, household, and psychological dimensions to measure women's empowerment. The sample data were then randomly divided for exploratory factor analysis (EFA) and Confirmatory Factor Analysis (CFA) to identify and validate a comprehensive multidimensional framework.ResultsOut of 625 respondents, only 36% of women worked, and ~39% married before age 18. Employing thirty-three items in EFA led to identifying eight critical factors (economic independence, control over household financial decisions, household decision-making, reproductive decision-making, freedom of movement, media exposure, positive self-esteem, and negative self-esteem). These factors, which explained 72.661% of the total variance in the data, provide a practical framework for understanding and addressing women's empowerment. Each component was then divided into two sub-dimensions to acquire a better understanding. The CFA indicated a good model fit for each dimension, and convergent and discriminant validity assessments were used to establish reliability and validity, further enhancing the practical implications of our findings.ConclusionsThe results of our rigorous exploratory and confirmatory factor analyses not only confirmed the sample structures and internal consistency but also provided significant insights. The findings suggested an adequate fit for all CFA models, indicating the robustness of our measurement model. According to the CFA results, each dimension's variables are satisfactory, and all the dimensions can be combined to create a single index measuring women's empowerment. This comprehensive understanding of women's empowerment, with its specific dimensions and factors, equips policymakers and practitioners with the knowledge to develop a wide range of interventions appropriate to particular facets of empowerment, thereby fostering societal growth and gender equality.
Waste, the real villain: a comprehensive analysis and prospective perspective on food loss and waste in China
Authors: Xu Peizhe , Shao Kaichao 
Published: November 2024

IntroductionOne of the best ways to ensure food security is to reduce Food Loss and Waste (FLW). However, China still confronts numerous obstacles in food loss and waste study because of the intricate industrial chain, the wide range of accounting standards, and a lack of data, among other reasons.MethodsUsing the literature analysis method, 119 literatures were collected and analyzed to examine the current status of FLW in China at various stages after food production and throughout the life cycle from the perspectives of time series and research areas.ResultsThe study indicates that the rates of FLW in China have been higher than 20% in recent years and are still increasing. Among them, the highest FLW rates were found in the harvesting stage (3–6%), storage stage (8–10%) and consumption stage (10–17%). In addition, FLW results in a huge waste of resource endowments.DiscussionThe environment and resources are profoundly affected by these substantial food losses and wastes, leading to unnecessary depletion of resources. As China’s focus on food loss and waste intensifies, an increasing number of academics are expected to delve into this area, exploring dimensions such as ecological footprint assessment, innovative uses for food waste, and gathering primary data.
Socioeconomic Inequalities in Out-of-Pocket and Catastrophic Health Expenditures in Pakistan
Authors: Bashir Saima , Kishwar Shabana , Nasir Muhammad , Ali Shehzad 
Published: November 2024

ObjectivesIn Pakistan, healthcare utilization is linked to out-of-pocket payments (OOP) which disproportionately affect low-income households. We investigated socioeconomic inequality in OOP and catastrophic health expenditures (CHEs), and the contribution of sociodemographic factors to these inequalities.MethodsSocioeconomic inequalities were quantified using the concentration index (CI), and the slope (SII) and relative (RII) indices of inequality using data from three rounds of Household Integrated Economic Survey (2007-08, 2011-12, and 2018-19). Decomposition analyses were conducted using the Wagstaff and Erreygers approach.ResultsOOP payments increased from PKR 127 (2007-08) to PKR 250 (2018-19). CHEs in the most deprived quintile (Q1) changed from 8.3% (2007-08) to 13.7% (2018-19), and for the least deprived quintile (Q5) from 5.1% (2007-08) to 8.4% (2018-19). The OOP CI increased from 0.028 to 0.051, while the SII and RII increased from 0.89 to 1.32 and 1.18 to 1.36, respectively. Decomposition analysis showed that household size, composition, employment, and the province of residence explained much of the socioeconomic inequality in CHEs.ConclusionPoor households experience high CHE, disproportionately impacting larger families with children and elderly members. Policymakers should implement targeted financial protection strategies to safeguard vulnerable households from the impoverishing effects of healthcare expenses.
Biocontrol Potential of a Native Trichoderma Collection Against Fusarium oxysporum f. sp. cubense Subtropical Race 4
Authors: Correa-Delgado Raquel , Brito-López Patricia , Cardoza Rosa E. , Jaizme Vega María C. , Laich Federico , Gutiérrez Santiago 
Published: November 2024

The Canary Islands lead banana (Musa acuminata) production in the EU. Different fungal pathogens affect this crop in subtropical areas, with Fusarium oxysporum f. sp. cubense subtropical race 4 (Foc-STR4) being the most important in the Canary Islands. With the aim of developing environmentally sustainable techniques for disease control, this study presents the results of the evaluation of the antifungal capacity of a native Trichoderma collection (12 species, 109 isolates) obtained from banana soils. The results demonstrate the diversity of biocontrol genes and the in vitro antagonistic potential of different native Trichoderma species/isolates against two Foc-STR4 strains obtained from plants with Panama disease symptoms. Trichoderma virens (TF18), a dominant species in banana soils in the Canary Islands, showed a high capacity to inhibit the growth of Foc-STR4 in different in vitro assays. Trichoderma atrobrunneum (TF01) showed mycoparasitism capacity through the spiral coil around the hyphae of the pathogen. In addition, the genome analysis of T. atrobrunneum (TF03) showed 69 putative biosynthetic gene clusters, with the notable presence of the trichothecene tri5 gene. Finally, our work demonstrates that the soils of the Canary Islands banana crops are a potential source of environmentally adapted biological control agents to control or reduce the incidence of Foc-STR4.
Cobalt(II) and Manganese(II) Complexes of Sodium Monensinate A Bearing Nitrate Co-Ligands
Authors: Petkov Nikolay , Boyadzhiev Miroslav , Bozhilova Nikita , Dorkov Petar , Encheva Elzhana , Ugrinov Angel , Pantcheva Ivayla N. 
Published: November 2024

Monensic acid is a natural polyether ionophore and is a therapeutic of first choice in veterinary medicine for the control of coccidiosis. Although known as a sodium-binding ligand, it can also form a variety of coordination species depending on experimental conditions applied. In this study, we present the crystal structures and properties of Co(II) and Mn(II) complexes of sodium monensinate (MonNa) derived from the reaction of MonNa with cobalt or manganese dinitrates. The newly obtained coordination compounds have the same composition [M(MonNa)2(NO3)2] but the transition metal ions are placed in a different environment. The two nitrate ligands behave mono- or bidentately bound in the Co(II)- and Mn(II)-containing species, respectively, while the monensinate ligands act in a similar manner through their monodentate carboxylate functions. The formed CoO4 and MnO6 units determine the geometry of the corresponding inner coordination cores of the complexes as a tetrahedron in the case of Co(II), and as a strongly distorted octahedral structure in Mn(II) species. The effect of inorganic anions on the antibacterial performance of sodium monensinate appears to be negligible, while the presence of Co(II) or Mn(II) cations preserves or enhances the activity of unmodified MonNa, which differentially affects the growth of Bacillus subtilis, Bacillus cereus, Kocuria rhizophila, Staphilococcus aureus, and Staphilococcus saprophyticus strains.