bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative Detection of Chicken and Turkey Contamination in Cooked Meat Products by ELISA
Authors: Thienes Cortlandt P , Masiri Jongkit , Benoit Lora A , Barrios-Lopez Brianda , Samuel Santosh A , Meshgi Mahzad A , Cox David P , Dobritsa Anatoly P , Nadala Cesar , Samadpour Mansour 
Published: July 2018

Abstract
Background: Concerns about the contamination of meat products with undeclared meats and new regulations for the declaration of meat adulterants have established the need for a rapid test to detect chicken and turkey adulteration. Objective: To address this need, Microbiologique, Inc. has developed an ELISA that can quantify the presence of chicken and turkey down to 0.1% (w/w) in cooked pork, horse, beef, goat, and lamb meats. Results: This chicken/turkey authentication ELISA has an analytical sensitivity of 0.000037% and 0.000048% (w/v) for cooked andautoclaved chicken, respectively, and an analyticalrange of quantitation of 0.025–2% (w/v), in the absence of other meats. The assay cross-reacts with cooked duck and pheasant but does not demonstrate any cross-reactivity with cooked pork, horse, beef, goat, and lamb meats, egg, or common food matrixes. Conclusions: The assay is rapid, can be completed in 70 min, and can detect a 0.1% level of meat adulteration. Highlights: The Microbiologique Cooked Chicken/TurkeyELISA can quantitate cooked chicken/turkey in the presence of pork, horse, chicken, goat, or sheep meat to 0.1% (w/w) and is not affected by common food matrixes.
Rational Energy Band Alignment and Au Nanoparticles in Surface Plasmon Enhanced Si‐Based Perovskite Quantum Dot Light‐Emitting Diodes
Authors: Liu Jingjing , Zhang Xianju , Ji Yang , Sheng Xuexi , Ma Haiguang , Xu Xiangxing , Yu Linwei , Xu Jun , Chen Kunji 
Published: July 2018

AbstractCombining inorganic perovskite quantum dots (IPQDs) devices with Si platform is an interesting topic since it is helpful for realizing the optoelectronic integration as well as the multiple‐functional electronics in a compact and lightweight format. However, the poor energy band alignment between the IPQDs and Si limits the device performance, such as the emitting efficiency. Here, a light‐emitting diodes (LEDs) structure is proposed by inserting a poly‐TPD (poly[N,N′‐bis(4‐butylphenyl)‐N,N′‐bis(phenyl)‐benzidine]) layer between the n‐type IPQDs and the p‐type Si substrate. The light‐emitting diode based on CsPbI3 quantum dots reaches an output power density of 1.68 mW cm−2 with external quantum efficiency of 0.91%, which is enhanced by 34‐fold compared with the reference device. Similar emission enhancement is also observed in the device based on CsPbBr3 quantum dots but the output power density is only 0.6 mW cm−2. In order to further improve the emission intensity of CsPbBr3 quantum dots devices, Au nanoparticals (Au NPs) are introduced into the hole injection layer, the output power density increases to 1.2 mW cm−2, which is induced by the localized surface plasmon resonance coupling between Au NPs and CsPbBr3 excitons. The results demonstrate that high‐efficiency and stable Si‐based perovskite LEDs can be realized by rational optical and electronic design.
A Silver Nanocluster Containing Interstitial Sulfur and Unprecedented Chemical Bonds
Authors: Liu Xu , Chen Jishi , Yuan Jinyun , Li Yizhi , Li Jin , Zhou Shiming , Yao Chuanhao , Liao Lingwen , Zhuang Shengli , Zhao Yan , Deng Haiteng , Yang Jinlong , Wu Zhikun 
Published: July 2018

AbstractThe emergence of thiolated metal nanoclusters provides opportunities to identify significant and unprecedented phenomena because they are at quantum sizes and can be characterized with X‐ray crystallography. Recently silver nanoclusters have received extensive interest owing to their merits, such as low‐cost and rich properties. Herein, a thiolated silver nanocluster [Ag46S7(SPhMe2)24]NO3 (Ag46 for short) with a face‐centered cubic (fcc) structure was successfully synthesized and structurally resolved by X‐ray analysis. Most importantly, interstitial sulfur was found in the lattice void of Ag46 without lattice distortion or expansion, indicating that the classic theory of interstitial metal solid solutions might be not applicable at quantum size. Furthermore, unprecedented chemical bonds and unique structural features (such as asymmetrically coordinated μ4‐S) were found in Ag46 and might be related to the interstitial sulfur, which is supported by natural population analyses.
Enantioselective α‐Benzylation of Acyclic Esters Using π‐Extended Electrophiles
Authors: Schwarz Kevin J. , Yang Chao , Fyfe James W. B. , Snaddon Thomas N. 
Published: July 2018

AbstractThe first asymmetric cooperative Lewis base/palladium catalyzed benzylic alkylation of acyclic esters is reported. This reaction proceeds via stereodefined C1‐ammonium enolate nucleophiles. Critical to its success was the identification of benzylic phosphate electrophiles, which were uniquely reactive. Alkylated products were obtained with very high levels of enantioselectivity, and this method has been applied toward the synthesis of the thrombin inhibitor DX‐9065a.
The GreedEx experience: Evolution of different versions for the learning of greedy algorithms
Authors: Arroyo Yoel , Molina Ana I. , Lacave Carmen , Redondo Miguel A. , Ortega Manuel 
Published: July 2018

AbstractThis paper presents the evolution experienced by GreedEx, an interactive application to learn greedy algorithms. It shows the four different versions currently available. A first original version for computers, two versions for iPad, and another version for smartphones. Besides, it describes the evaluation performed for each version, which has served so as to justify such evolution.
Rituximab maintenance improves overall survival in follicular lymphoma: A retrospective nationwide real‐world analysis from Taiwan Cancer Registry Database
Authors: Huang Huai‐Hsuan , Wen Yao‐Chun , Chen Ho‐Min , Hsiao Fei‐Yuan , Ko Bor‐Sheng 
Published: July 2018

AbstractFollicular lymphoma (FL) is the most frequent indolent lymphoma in Western countries, but it is less frequent in Asia. Several trials have demonstrated the progression‐free benefit of rituximab maintenance for FL patients in Western countries. However, the overall survival (OS) benefits and effectiveness of rituximab maintenance in Asian FL patients remain uncertain. We utilized the Taiwan Cancer Registry Database and the National Health Insurance Research Database to investigate the roles of rituximab maintenance for newly diagnosed FL patients in Taiwan. Among 836 patients with newly diagnosed FL during 2009‐2012, we enrolled patients with stage II‐IV diseases receiving 4‐8 cycles of rituximab‐containing induction chemotherapies (R‐induction). We excluded those who died or received additional chemotherapy within 180 days after R‐induction. Among the 396 enrolled patients, 260 underwent rituximab maintenance (R‐maintenance group), and 136 served as the observation group. The R‐maintenance group received less anthracycline and fewer cycles of R‐induction than the observation group, but they exhibited a significantly better OS both in the univariate and multivariate analyses [hazard ratio, 0.42; 95% confidence interval, 0.19‐0.91] after adjusting for age, sex, and Ann Arbor stages. Meanwhile, we also found more patients required further therapies in the first 6 months after the cease of rituximab maintenance. In the subgroup analysis, patients older than 60 years or with stage IV diseases benefited more from rituximab maintenance. Conclusively, our nationwide study is the first one to demonstrate the OS benefit of rituximab maintenance after induction therapies in newly diagnosed FL patients from Asian populations.
Effect of marital status on survival in glioblastoma multiforme by demographics, education, economic factors, and insurance status
Authors: Xie Jun‐Chao , Yang Shuai , Liu Xue‐Yuan , Zhao Yan‐Xin 
Published: July 2018

AbstractThe relationship between marital status and glioblastoma multiforme (GBM) has not been addressed in depth. Here, we aimed to investigate the association between marital status and survival in GBM. We searched the Surveillance, Epidemiology, and End Results (SEER) database and extracted the data of eligible patients diagnosed with GBM after 2004. Marital status was classified as married, divorced/separated, widowed, and single. A Kaplan‐Meier test was conducted to compare the survival curves of different groups. Multivariate Cox regression was performed to evaluate overall survival (OS) and cause‐specific survival (CSS) in different groups. Subgroup analysis was applied according to demographics, typical education and income levels in the locale, and insurance status. A total of 30 767 eligible patients were included. The median OS values were 9, 7, 3, 9 months in married, divorced/separated, widowed, and single patients, respectively. After adjustment for other covariates, married patients had better OS and CSS than other patients had. In addition to marital status, demographic factors, disease progression factors, local educational level, and insurance status were also associated with survival in GBM. Furthermore, subgroup analyses revealed the protective effect of marriage in most of the comparisons. Notably, the protective effect of marriage becomes more and more apparent as time goes on. The advantageous effect of marriage on GBM survival is especially prominent in patients who are male, older than 60 years of age, White, or living in middle‐income counties. In conclusion, marital status is an independent prognostic factor for GBM.
Alkali‐Oxygen Batteries Based on Reversible Superoxide Chemistry
Authors: McCulloch William David , Xiao Neng , Gourdin Gerald , Wu Yiying 
Published: July 2018

AbstractRechargeable superoxide (O2−) batteries have the potential to surpass current lithium‐ion technology due to their high theoretical energy densities. The use of superoxides as an energy storage material is highly advantageous when compared to their close relatives, peroxides. This is due to enhanced reversibility of the 1‐electron redox process. To efficiently stabilize superoxides, larger metal cations are required such as sodium and potassium. Therefore, the two most studied systems are sodium and potassium‐oxygen batteries. Both batteries present unique advantages and challenges. In this minireview, we summarize the current research for each superoxide‐based battery and offer perspective for further research.
Iterative Assembly of Macrocyclic Lactones using Successive Ring Expansion Reactions
Authors: Stephens Thomas C. , Lawer Aggie , French Thomas , Unsworth William P. 
Published: July 2018

AbstractMacrocyclic lactones can be prepared from lactams and hydroxyacid derivatives via an efficient 3‐ or 4‐atom iterative ring expansion protocol. The products can also be expanded using amino acid‐based linear fragments, meaning that macrocycles with precise sequences of hydroxy‐ and amino acids can be assembled in high yields by “growing” them from smaller rings, using a simple procedure in which high dilution is not required. The method should significantly expedite the practical synthesis of diverse nitrogen containing macrolide frameworks.
Precessional Motion in Crystalline Solid Solutions of Ionic Rotors
Authors: d'Agostino Simone , Fornasari Luca , Grepioni Fabrizia , Braga Dario , Rossi Federica , Chierotti Michele R. , Gobetto Roberto 
Published: July 2018

AbstractThe order–disorder phase transition associated with the uprise of reorientational motion in (DABCOH2)2+, in the supramolecular salts of general formula [1⋅(DABCOH2)]X2 (where 1=12‐crown‐4, DABCO=1,4‐diazabicyclo[2.2.2]octane, and X=Cl− or Br−), has been investigated by variable temperature X‐ray diffraction on single crystals and powder samples, as well as by DSC and solid‐state NMR spectroscopy (SSNMR). The two compounds undergo a reversible phase change at 292 and 290 K, respectively. The two crystalline materials form solid solutions [1⋅(DABCOH2)]Cl2xBr2(1−x) in the whole composition range (0 < x<1), with a decrease in the temperature of transition to a minimum of ca 280 K, corresponding to x=0.5. Activation energy values for the dynamic processes, evaluated by variable‐temperature 13C magic‐angle spinning (MAS) SSNMR and line‐shape analysis are ca. 50 kJ mol−1 in all cases. Combined diffraction and spectroscopic evidence has allowed the detection of a novel dynamic process for the (DABCOH2)2+ dications, based on a room temperature precessional motion that is frozen out below the disorder–order transition; to the best of the authors’ knowledge this phenomenon has never been observed before.
Synthesis of Structurally Diverse N‐Substituted Quaternary‐Carbon‐Containing Small Molecules from α,α‐Disubstituted Propargyl Amino Esters
Authors: Mateu Natalia , Kidd Sarah L. , Kalash Leen , Sore Hannah F. , Madin Andrew , Bender Andreas , Spring David R. 
Published: July 2018

AbstractN‐containing quaternary stereocenters represent important motifs in medicinal chemistry. However, due to their inherently sterically hindered nature, they remain underrepresented in small molecule screening collections. As such, the development of synthetic routes to generate small molecules that incorporate this particular feature are highly desirable. Herein, we describe the diversity‐oriented synthesis (DOS) of a diverse collection of structurally distinct small molecules featuring this three‐dimensional (3D) motif. The subsequent derivatisation and the stereoselective synthesis exemplified the versatility of this strategy for drug discovery and library enrichment. Chemoinformatic analysis revealed the enhanced sp3 character of the target library and demonstrated that it represents an attractive collection of biologically diverse small molecules with high scaffold diversity.
An automated independent workflow for the analysis of massively parallel sequence data from forensic SNP assays
Authors: Vlachos Nicholas T , Meiklejohn Kelly A , Robertson James M 
Published: July 2018

AbstractIllumina and Thermo Fisher Scientific have developed assays that permit the sequencing of forensically relevant single nucleotide polymorphisms (SNPs), along with software to determine the associated genotypes. Currently there is no method to either independently confirm the genotypes determined using the manufacturer's software, or to compare genotypes and quality metrics among samples processed using both platforms. This paper outlines an automated workflow developed in CLC Genomics Workbench that permits accurate, fast and independent analysis of SNP sequence data from either platform. To facilitate the straightforward comparison of genotypes generated from both the manufacturer's software and the independent CLC analysis, a Python script was written. Data for a total of 323 forensically relevant ancestry, identity and phenotypic SNPs can be analyzed, and the resulting genotypes, coverage, quality flags and major allele frequencies are easily compared across samples and platforms.
DNA ladders can be used to size polyphosphate resolved by polyacrylamide gel electrophoresis
Authors: Smith Stephanie A. , Wang Yan , Morrissey James H. 
Published: July 2018

AbstractPAGE is often used to resolve inorganic polyphosphates (polyP), but unfortunately polyP size ladders are not commercially available. Since several dyes that are commonly used to detect nucleic acids in gels also stain polyP, we examined the utility of commercially available DNA size ladders for estimating polyP polymer lengths by gel electrophoresis. Narrow size fractions of polyP were prepared and their polymer lengths were quantified using NMR. Commercially available DNA ladders and these polyP fractions were then subjected to PAGE to determine the relationship between migration of DNA vs polyP, which was found to be: log10(dsDNA length in bp) = 1.66 × log10(polyP length in phosphate units) − 1.97. This relationship between DNA and polyP size held for a variety of different polyacrylamide concentrations, indicating that DNA size ladders can readily be employed to estimate polyP polymer lengths by PAGE.
Liquids‐to‐Power Using Low‐Temperature Solid Oxide Fuel Cells
Authors: Hussain A. Mohammed , Wachsman Eric D. 
Published: July 2018

AbstractSolid oxide fuel cells (SOFCs) operating at high temperatures (>800 °C) have been overlooked in the past for automotive applications, primarily due to their longer start‐up times and inability to load follow (quickly respond to varying power demands). However, lower operating temperature SOFCs (LT‐SOFCs) enable more rapid start‐up and several other benefits. The rapid deployment of cost‐effective LT‐SOFC technology for automotive applications relies on the utilization of conventional ‘‘drop‐in’’ fuels (e. g., gasoline, diesel, ethanol etc.), that adapts the existing fuel distribution infrastructure. In particular, the liquid‐fed LT‐SOFCs have the potential to deliver higher “well‐to‐wheels” fuel conversion efficiencies than H2‐fed fuel cells as well as take advantage of the higher fuel energy density. Therefore, this review focuses on the benefits/challenges of low‐temperature SOFCs (350–650 °C) running on liquid fuels. The critical role of anodes and requirements/status of advanced anode materials for the direct utilization of liquid fuels in LT‐SOFCs are highlighted.
Incidence and farmers’ knowledge of aflatoxin contamination and control in Eastern Democratic Republic of Congo
Authors: Udomkun Patchimaporn , Wossen Tesfamicheal , Nabahungu Nsharwasi L. , Mutegi Charity , Vanlauwe Bernard , Bandyopadhyay Ranajit 
Published: July 2018

AbstractDespite efforts to reduce aflatoxin contamination and associated mycotoxin poisoning, the phenomenon continues to pose a public health threat in food and feed commodity chains. In this study, 300 samples of cassava, maize, and groundnut were collected from farmers’ households in Eastern DRC and analyzed for incidence of aflatoxins. In addition, the farmers’ level of knowledge of the causes and consequences of contamination and the measures for prevention were also examined by administering questionnaires to a cross section of 150 farmers. The results showed the presence of aflatoxins in all samples, with levels ranging from 1.6 to 2,270 μg/kg. In 68% of all samples, total aflatoxin contamination was above 4 μg/kg, the maximum tolerable level set by the European Union. Farmers ranked high humidity, improper storage practices, and poor soils as potential causes of aflatoxin contamination and changes in color, smell, and taste, and difficulty in selling crops as consequences. They identified crop management practices as the most effective way to control contamination. The results also revealed that most farmers apply preharvest crop management practices as a means of controlling contamination. More educated households were more knowledgeable about aflatoxins. Female‐headed and married households were less likely to be willing to pay for aflatoxin control. About 28% of farmers claimed to be willing to allocate resources to seed intervention while a smaller proportion agreed to pay for training and information services. The result further suggests that an adoption of pre‐ and postharvest technologies together with awareness creation is still required to reduce aflatoxin contamination in the country.
Functional connectivity in category‐selective brain networks after encoding predicts subsequent memory
Authors: Collins Jessica A. , Dickerson Bradford C. 
Published: July 2018

AbstractActivity in category selective regions of the temporal and parietal lobes during encoding has been associated with subsequent memory for face and scene stimuli. Reactivation theories of memory consolidation predict that after encoding connectivity between these category‐selective regions and the hippocampus should be modulated and predict recognition memory. However, support for this proposal has been limited in humans. Here, participants completed a resting‐state functional MRI (fMRI) scan, followed by face‐ and place‐encoding tasks, followed by another resting‐state fMRI scan during which they were asked to think about the stimuli they had previously encountered. Individual differences in face recognition memory were predicted by the degree to which connectivity between face‐responsive regions of the fusiform gyrus and perirhinal cortex increased following the face‐encoding task. In contrast, individual differences in scene recognition were predicted by connectivity between the hippocampus and a scene‐selective region of the retrosplenial cortex before and after the place‐encoding task. Our results provide novel evidence for category specificity in the neural mechanisms supporting memory consolidation.
Effect of Notch1 gene on remyelination in multiple sclerosis in mouse models of acute demyelination
Authors: Fan Hua , Zhao Jie‐Gang , Yan Jun‐Qiang , Du Gan‐Qin , Fu Qi‐Zhi , Shi Jian , Yang Yan‐Hui , Du Xiao‐Wei , Bai Xiao‐Li 
Published: July 2018

AbstractThis study aims to explore the effects of Notch1 gene on remyelination in multiple sclerosis (MS). A mouse model of acute demyelination was successfully established and the model mice were grouped as cuprizone (CPZ) group, CPZ + small interfering RNA (siRNA)‐Notch1 (siNotch1) group, and CPZ + siRNA negative control (NC) group. Meanwhile, another 3 groups (control, control + siNotch1, and control + siRNA NC) were established in normal mice. The changes of weight and maintenance time in rotating drum of mice were observed. Western blot analysis for the protein expressions related to Notch signaling pathway and oligodendrocyte (OL) differentiation in the corpus callosum of the mice. After model establishment, the weight of CPZ‐induced demyelinated mice was decreased. During the repair period, the balance ability and movement of the mice was recovered, especially for those injected with siNotch1 plasmid. After model establishment, the number of myelinated axons was decreased. In comparison with the CPZ and CPZ siRNA NC groups, the CPZ + siNotch1 group had a decrease in the number of premature OLs, but increase in mature OLs, and a decrease in oligodendrocyte precursor cells and astrocytes. The expressions of proteins related to Notch signaling pathway, such as HES, Jagged‐1 were decreased in the CPZ + siNotch1 group in contrast to the CPZ and CPZ + siRNA groups, but the OL‐related transcription factor Sox10 was increased in the CPZ + siNotch1 group than in the CPZ + siRNA NC and CPZ groups, and Id2 was decreased. Our study provided evidence that the inhibition of Notch1 gene could accelerate remyelination in MS.