bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Oncologists Perceive the Availability and Quality of Information Generated From Patient-Reported Outcomes (PROs)
Authors: Shea Michael , Audibert Céline , Stewart Mark , Gentile Brittany , Merino Diana , Hong Agnes , Lassiter Laura , Caze Alexis , Leff Jonathan , Allen Jeff , Sigal Ellen 
Published: March 2019

Background: Despite increased incorporation of patient-reported outcome (PRO) measures into clinical trials, information generated from PROs remains largely absent from drug labeling and electronic health records, giving rise to concerns that such information is not adequately informing clinical practice. Objective: To evaluate oncologists’ perceptions concerning the availability and quality of information generated from PRO measures. Additionally, to identify whether an association exists between perceptions of availability and attitudes concerning quality. Method: An online, 11-item questionnaire was developed to capture clinician perspectives on the availability and use of PRO data to inform practice. The survey also asked respondents to rate information on the basis of 4 quality metrics: “usefulness,” “interpretability,” “accessibility,” and “scientific rigor.” Results: Responses were received from 298 of 1301 invitations sent (22.9% response rate). Perceptions regarding the availability of PRO information differed widely among respondents and did not appear to be linked to practice setting. Ratings of PRO quality were generally consistent, with average ratings for the 4 quality metrics between “satisfactory” and “good.” A relationship was observed between ratings of PRO data quality and perceptions of the availability. Conclusion: Oncologists’ attitudes toward the quality of information generated from PRO measures are favorable but not enthusiastic. These attitudes may improve as the availability of PRO data increases, given the association we observed between oncologists’ ratings of the quality of PRO information and their perceptions of its availability.
Inability to Belch and Associated Symptoms Due to Retrograde Cricopharyngeus Dysfunction: Diagnosis and Treatment
Authors: Bastian Robert W. , Smithson Melissa L. 
Published: March 2019

ObjectiveTo propose and test the validity of a new syndrome called retrograde cricopharyngeus dysfunction (R‐CPD) that explains inability to belch and the associated symptoms of loud gurgling noises, chest and abdominal pain/distention, and excessive flatulence, as well as to report the results of botulinum toxin (BT) injection into the cricopharyngeus muscle (CPM) for both diagnosis and treatment of R‐CPD.Study DesignTo develop a case series of consecutive patients matched to the syndromic features of R‐CPD, inject the CPM with BT as a concurrent diagnostic and therapeutic maneuver, and assess results.SettingBastian Voice Institute (Downers Grove, Illinois).Subjects and MethodsConsecutive (unselected) patients presenting with inability to belch and associated symptoms were matched to the proposed syndrome of R‐CPD, treated with BT, and followed for effect on symptoms over time.ResultsAll 51 patients achieved ability to belch and relief of associated symptoms, and the majority seem to have “retrained” the ability to belch on a potentially “permanent” basis.ConclusionR‐CPD can be diagnosed syndromically, using a symptom complex; clinical diagnosis is validated by relief of symptoms after BT injection; and BT into the CPM is an efficacious treatment, whose benefit appears to often last longer than the pharmacologic duration of action of BT.
Impact of fatty acid binding protein 5‐deficiency on COPD exacerbations and cigarette smoke‐induced inflammatory response to bacterial infection
Authors: Rao Deviyani M. , Phan Della T. , Choo Michelle J. , Weaver Michael R. , Oberley‐Deegan Rebecca E. , Bowler Russell P. , Gally Fabienne 
Published: March 2019

AbstractBackgroundAlthough cigarette smoking (CS) is by far the most important risk factor of chronic obstructive pulmonary disease (COPD), repeated and sustained infections are clearly linked to disease pathogenesis and are responsible for acute inflammatory flares (i.e. COPD exacerbations). We have previously identified Fatty Acid Binding Protein 5 (FABP5) as an important anti‐inflammatory protein in primary airway epithelial cells.ResultsIn this study we found decreased FABP5 mRNA and protein levels in peripheral blood mononuclear cells (PBMCs) of COPD patients, especially among those who reported episodes of COPD exacerbations. Using wildtype (WT) and FABP5−/− mice, we examined the effects of FABP5 on CS and infection‐induced inflammatory responses. Similarly to what we saw in airway epithelial cells, infection increased FABP5 expression while CS decreased FABP5 expression in mouse lung tissues. CS‐exposed and P. aeruginosa‐infected FABP5−/− mice had significantly increased inflammation as shown by increased lung histopathological score, cell infiltration and inflammatory cytokine levels. Restoration of FABP5 in alveolar macrophages using a lentiviral approach attenuated the CS‐ and bacteria‐induced pulmonary inflammation. And finally, while P. aeruginosa infection increased PPARγ activity, CS or FABP5 knockdown greatly reduced PPARγ activity.ConclusionsThese findings support a model in which CS‐induced FABP5 inhibition contributes to increased inflammation in COPD exacerbations. It is interesting to speculate that the increased inflammation is a result of decreased PPARγ activity.
Unsupervised machine learning applied to scanning precession electron diffraction data
Authors: Martineau Ben H. , Johnstone Duncan N. , van Helvoort Antonius T. J. , Midgley Paul A. , Eggeman Alexander S. 
Published: March 2019

AbstractScanning precession electron diffraction involves the acquisition of a two-dimensional precession electron diffraction pattern at every probe position in a two-dimensional scan. The data typically comprise many more diffraction patterns than the number of distinct microstructural volume elements (e.g. crystals) in the region sampled. A dimensionality reduction, ideally to one representative diffraction pattern per distinct element, may then be sought. Further, some diffraction patterns will contain contributions from multiple crystals sampled along the beam path, which may be unmixed by harnessing this oversampling. Here, we report on the application of unsupervised machine learning methods to achieve both dimensionality reduction and signal unmixing. Potential artefacts are discussed and precession electron diffraction is demonstrated to improve results by reducing the impact of bending and dynamical diffraction so that the data better approximate the case in which each crystal yields a given diffraction pattern.
IMPLEMENTASI PROGRAM NASIONAL PEMBERDAYAAN MASYARAKAT (PNPM) DI KOTA SEMARANG
Authors: Nurcahyanto Herbasuki 
Published: March 2019

Poverty is a main issue tosolve. National Urban Program for People Empowerment (PNPM MP) has main program to alleviate poverty by involving participation of the villagers. The purpose of the research is to analyze the implementation and identify the inhibiting factors of PNPM MP, in Mangunharjo residence Tembalang District Semarang. The approach used is descriptive qualitative approach. The implementation of PNPM MP in Mangunharjo was started in 2007. Direct People Assistance (Bantuan Langsung Masyarakat/BLM) received are used to alleviate poverty through three areas: economy, social and environment. Self-Assistance Groups (Kelompok Swadaya Masyarakat/KSM) has easy access to obtain additional capital to run a business. Poor villagers are asissted through house rehabilitation program and education package. The negative Impacts also come up that there is social envy especially for those who do not receive the assistance. The inhibitting factors of the implementation of PNPM MP in Mangunharjo Residence include the internal factors: The limited number of the operating unit members, Some BKM members are not active in some activities, The KSM members do not have sufficient skill to arrange the proposal. While the external factors include: the distrust of villagers toward the credibility of KSMmembers to implement physical projects, and the envy shown by those who do not get BKM. To increase the awareness of the BKM and KSM members are through trainings, assistingKSM to prepare the project proposals and eventhe reports regularly and continuously. There should be a socialization to the villagers about the programs managed by BKM through regular meetings of RT / RW or the engagement of the community leaders to take a part routinely in the annual meeting forum of the villagers (Rembug Warga Tahunan/RWT).
SISTEM MONITORING VOLUME AIR MENGGUNAKAN SENSOR ULTRASONIK DAN MONITORING OUTPUT VOLUME AIR MENGGUNAKAN FLOW METER BERBASIS ARDUINO
Authors: Br Pelawi Servinta Damayanti , Manan Saiful 
Published: March 2019

Servinta Damayanti Br Pelawi,Saiful Manan, in this paper explain that method of realization of making purification and monitoring volume of water, purification of water using small molecules such as sand, charcoal, cotton, etc. and monitoring the volume of water using the HC-SR04 ultrasonic sensor. where this ultrasonic sensor will detect the water inside the sensor distance sensor to objects that is 2cm and 25cm. When the water has reached the limit of 2cm and 15cm then the buzzer will light up giving a warning. and will display on the HMI in the form of cm, to run the pump we click the start button at hmi the pump will turn on and the water inside the reservoir will enter reverse osmosis, Ro will process water, clean water will be read by the flow meter, flow meter will detect incoming water and will display the results in the HMI in the form liter, and Arduino UNO is used as a control system for HMI output input signals, sensors, flow meters, and buzzers. Keywords: Ultrasonic Sensor, Buzzer, Flow Meter, Arduino Uno and HMI.ReferencesIqbal, Mohammad. (2014). Rancang Bangun monitoring volume air menggunakan mikrokontroler atmega 8535 berbasis Borland Delphi 7. Semarang: Universitas Diponegoro.Yudhanto,Saktyo. 2012. Tandon Air Otomatis Berbasis Mikrokontroler ATmega 16.Rinalakbar. Alat Ukur Magnetic Flow Meter Diakses pada 10 Januari 2010, 10:31 WIB.Andrianto,Heri,Arduino Belajar Cepat dan Pemrograman .Informatika Bandung. Diakses pada januari 2016.Arin.2016. Pengendali Tekanan Pompa dngan Pmw(Pulse Width Modulation) Pada Membran Ro .Tugas Akhir Tidak Terpublikasi.Semarang: Universitas Diponegoro
ANALISA PERHITUNGAN BALLAST PADA PELUNCURAN MENYAMPING (SIDE LAUNCHING) KAPAL SUNGAI 200GT DI PT. DKB (PERSERO) CABANG SEMARANG
Authors: Ariany Zulfaidah 
Published: March 2019

Considering the risk faced in the side launching, limited land from the shipyard so that required calculation and analysis in the implementation of the launching. The purpose of this research is analyzes and counting ballast (a counterweight ) used in a river boat lct 200 GT on the launching of sideways ( side launching ) so that safe and floats can be perfect in water, as nown that the launching of is one of the stages important in the development process the new vessel which have prepared to be operated, formerly preceded by stage first cutting plate ( cutting first steel plate ) and the keel laying ( laying ) keel of a ship. Before the handover of a vessel is carried, a ship will had some sea trial. The results of this research is scientific publication in national journal , as a input for the shipyard to implement the launch sideways safe as well as the basis for students and teachers included in matter basic lecture subjects of case in point in lecture the theory ship building . Keywords: Launching; Side Launching; Ballast
EFISIENSI TEKNIS DAN SELEKTIVITAS ALAT TANGKAP JARING INSANG (GILLNET) TERHADAP KOMPOSISI HASILTANGKAPAN DI PERAIRAN SEMARANG (Technical Efficiency and Selectivity of Fishing Gear Gillnet to Composition of Fish Capture in Semarang Water)
Authors: Putri Vatharany Liana , Kurohman Faik , Fitri Aristi Dian Purnama 
Published: March 2019

Pengoperasian Gill Net akan berpengaruh terhadap stok sumberdaya ikan apabila tidak diatur dengan baik. Strategi manajemen sumberdaya ikan diperlukan agar optimalisasi hasil tangkapan dan kelestarian sumberdaya ikan tetap terjaga. Tujuan dari penelitian ini adalah untuk menganalisis nilai efisiensi teknis dan nilai selektivitas alat tangkap Jaring Insang (Gill Net ) terhadap komposisi hasil tangkapan. Metode penelitian yang digunakan adalah deskriptif bersifat studi kasus. Lokasi penelitian di perairan Semarang. Obyek pengamatan adalah Gill Net . Analisis data yang digunakan adalah uji Independent T-Test. Hasil Penelitian menunjukkan bahwa alat tangkap Gill Net terdapat dua mesh size yaitu 1,4 inci dan 3,5 inci. Total hasil tangkapan Gill Net dengan mesh size 1,4 inci sebesar 38.350 kg sedangkan Gill Net dengan ukuran 3,5 inci sebesar 15.220 kg. Nilai efisiensi yang terdapat pada mesh size 1,4 inci adalah 30 sedangkan, mesh size 3,5 inci memperoleh poin sebesar 20. Berdasarkan pengolahan uji Independent T-test bahwa terdapat pengaruh signifikan antara komposisi hasil tangkapan Gill Net terhadap mesh size 1,4 inci dan 3,5 inci. Kesimpulan yang diperoleh dari penelitian ini adalah status alat tangkap Gill Net dengan mesh size 1,4 inci lebih efisien daripada mesh size 3,5 inci. The way to operation the Gill Net will affect the stock of fish resources if not properly regulated. Strategy to manage the fish resources is needed to optimize amount of catch and create the sustainable fish resources. The aim of research was to analyze level of technical efficiency and selectivity Gillnets to the composition of the catches. The research method used case study on technical efficiency Gillnets in Semarang’s waters. The results of the research, Gillnets have two mesh size, 1.4 inch and 3.5 inch. Total catch of Gillnets with mesh size 1.4 inch was 38.350 kg while Gillnets catch with mesh size 3.5 inch was 15.220 kg. Based on independence T-test that there was significant influence between the composition of Gillnets catches to mesh size 1.4 inch and 3,5 inch. efficiency point with mesh size 1,4 inch was 30, whereas mesh size 3,5 inch obtained 20 point. The conclusion from this research is stat us of fishing gear Gillnets with mesh size 1,4 inch more efficient than mesh size 3,5 inch.
SEBARAN SPASIO TEMPORAL KELIMPAHAN FITOPLANKTON DAN KLOROFIL-A DI PERAIRAN UJUNG KARTINI JEPARA (Spatial and Temporal Distribution Abundance of Phytoplankton and Chlorophyll-a in Ujung Kartini Waters Jepara)
Authors: Yulianto Muchtar , Muskananfola Max Rudolf , Rahman Arif 
Published: March 2019

Perairan Ujung Kartini merupakan perairan yang menjadi muara dari Sungai Wiso dan Sungai Kanal yang terletak di sisi barat Kabupaten Jepara. Di sekitar Perairan Ujung Kartini terdapat kegiatan manusia yang dikhawatirkan dapat menyebabkan perubahan kualitas air terutama kandungan unsur hara. Perubahan kandungan unsur di perairan akan berdampak terhadap persebaran dan kelimpahan fitoplankton serta konsentrasi klorofil-a. Penelitian ini bertujuan untuk mengetahui tingkat kesuburan perairan dan hubungan antara kelimpahan fitoplankton dengan konsentrasi klorofil-a. Penelitian dilakukan pada bulan November dan Desember 2017. Penelitian ini termasuk jenis penelitian analisis deskriptif dan penentuan lokasi sampling menggunakan metode purposive sampling. Pengambilan sampel air dan fitoplankton dilakukan di tiga stasiun yang ditentukan berdasarkan tinggi rendahnya kegiatan manusia. Pengambilan sampel tersebut dilakukan pada saat kondisi pasang dan surut dengan dua kali pengulangan. Hasil penelitian yang diperoleh menunjukan bahwa kelimpahan fitoplankton pada saat pasang dan surut berkisar antara 6.375 – 13.725 sel/l dan konsentrasi klorofil-a pada saat pasang dan surut berkisar antara 0,126 – 1,392 mg/m3. Nilai diatom quotient sebesar 1,533 yang berarti perairan yang diteliti termasuk ke dalam kategori perairan eutrofik. Kelimpahan fitoplankton dan konsentrasi klorofil-a pada saat pasang lebih tinggi daripada saat surut. Keduanya mempunyai hubungan yang sangat erat. Ujung Kartini Waters is part of the estuary of the Wiso River and Kanal River which are located on the west side of Jepara Regency. In the surrounding area, there are human activities that are feared to cause changes in water quality, especially nutrient content. Changes in nutrients content in the waters will have impact on the distribution and abundance of phytoplankton and concentration of chlorophyll-a. This study aims to determine the level of aquatic productivity and the relationship between phytoplankton abundance with chlorophyll-a concentration. The study was conducted from November to December 2017. This research includes descriptive analysis and determination of sampling location using purposive sampling method. Samples of water and phytoplankton were collected at three stations based on the level of human activity. Sampling was carried out during high tide and low tide with two repetitions. Based on the results of the research, the abundance of phytoplankton at high and low tides ranged between 6.375 - 13.725 cells/l and chlorophyll-a concentrations at high and low tides ranged between 0,126 – 1,392 mg/m3. The value of diatom quotient is 1,533 which means that the waters of study area belong to the eutrophic category. The abundance of phytoplankton and concentrations of chlorophyll-a at high tide is higher than at low tide. Both show a high level relationship.
PRODUKTIVITAS PERIKANAN TANGKAP KOTA TEGAL
Authors: Hendrayana Hendrayana , Hartanti Ninik Umi 
Published: March 2019

Produktivitas perikanan tangkap Kota Tegal cenderung fluktuatif. Penelitian ini bertujuan untuk mengetahui laju pertumbuhan alat tangkap cantrang dan untuk mengetahui produktifitas perikanan tangkap di Kota Tegal Penelitian ini menggunakan metode penelitian deskriptif dan pengambilan sampel dilakukan dengan metode purposive sampling method. Hasil penelitian menunjukkan bahwa 90% kapal di PPP Tegalsari merupakan kapal cantrang. Hasil tangkapan ikan dari tahun 2015-2017 menurun sebesar 30,11%. Ikan ekonomis seperti kakap merah (Lutjanus bitaeniatus), ikan lidah (Cynoglossus lingua), ikan pari (Dasyatis sp), rajungan (Portunus pelagicus) sulit ditemukan di Perairan Tegal. Zona penangkapan berubah dimana awalnya dilakukan di Kawasan Perairan Tegal saat penangkapan dilakukan hingga Kawasan perairan kalimantan. Tegal capture fisheries productivity is fluctuating. The aims of this research was to determained cantrang fishing gear and Tegal capture fisheries productivity. The descriptive method and purposive sampling method was applied in this research. The results showed that 90% of the ship at PPP Tegalsari ships was cantrang ships. Fish catch from 2015-2017 decreased by 30.11%. Economic fish like Lutjanus bitaeniatus , Cynoglossus lingua , Dasyatis sp and Portunus pelagicus hard to find at Tegal Water. There need to be fishing gear and fish target in fishing activities.
POTENSI PANKREAS KAMBING SEBAGAI BATING AGENT ALAMI TERHADAP KARAKTERISTIK KULIT IKAN NILA (Oreochromus niloticus) TERSAMAK(Pancreas Potential Of Goat As A Natural Bating Agent On Tilapia (Oroeochromus niloticus) Leather)
Authors: Cahyana Muhammad Aziz , Amalia Ulfah , Suharto Slamet 
Published: March 2019

Pankreas kambing mengandung enzim proteolitik yang berpotensi sebagai bating agent dalam proses penyamakan kulit.Tujuan penelitian ini adalah mengetahui pengaruh penggunaan bating agent dari pankreas kambing terhadap karakteristik fisik kulit ikan nila tersamak dan mengetahui konsentrasi terbaik dari penggunaan bating agent pankreas kambing. Materi yang digunakan dalam penelitian ini adalah kulit ikan niladan pankreas kambing segar. Metode penelitian ini bersifat experimental laboratories menggunakan Rancangan Acak Lengkap (RAL) dengan tiga kali pengulangan dengan 4 konsentrasi bating agent yaitu (0,5%, 1%, 1,5% dan 2%) kulit ikan tersamak diuji dengankekuatan tarik, kemuluran, kekuatan sobek, kadar krom oksida, dan suhu kerut. Hasil penelitian menghasilkan bahan bating agent berpengaruh terhadap karakteristik kulit ikan tersamak (P<0,05). Konsentrasi bating agent sebesar 2% memberikan hasil yang terbaik sebagai berikut: kekuatan tarik 1300,45 N/cm², kemuluran 87,70%, kekuatan sobek 273,90 N/cm², kadar krom oksida 3,46 %, dan suhu kerut 99,75°C. Kulit ikan nila tersamak hasil penelitian semua perlakuan memenuhi persyaratan SNI 06-4586-1998 kecuali untuk parameter kemuluran tidak memenuhi syarat. Goat pancreas, containing proteolytic enzymes which the potential as a bating agent in the process of tanning the skin. The purpose of this study was to determine the effect of using bating agent from goat pancreas on the physical characteristics of tilapia skin and knowing the best concentration of using the goat pancreatic agent. The material used in this study is the skin of tilapia and fresh goat pancreas. This research method is experimental laboratories using Completely Randomized Design (CRD) with three repetitions with 4 concentrations of bating agent namely (0.5%, 1%, 1.5% and 2%) the skin of tanned fish is tested with tensile strength, elongation, tear strength, chrome oxide content, and wrinkle temperature. The results of the study resulted in bating agent material affecting the characteristics of tanned fish skin (P <0.05). Bating agent concentration of 2% gave the best results as follows: tensile strength 1300.45 N / cm², elongation 87.70%, tear strength 273.90 N / cm², chrome oxide content 3.46%, and wrinkle temperature 99, 75 ° C. The results of this study produced a total nitrogen of 2.65% of the goat pancreas which has great potential to be used as bating material. The skin of tanned tilapia from the results of this study meets the requirements of SNI 06-4586-1998 except for elongation parameters that do not meet the requirements.