bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing experiential augmentation of the environment in the valuation of wine: Evidence from an economic experiment in Mt. Etna, Italy
Authors: Pappalardo Gioacchino , Selvaggi Roberta , Pecorino Biagio , Lee Ji Yong , Nayga Rodolfo M. 
Published: March 2019

AbstractIn this study, we conducted an experimental auction to determine the impacts that “experiential augmentation,” a phenomenon in which a physical location impacts decision‐making, has on consumers’ willingness to pay (WTP) for wine. The experiment elicited subjects’ valuation under experiential augmentation conditions for three types of wine grown in the Mt. Etna area in Sicily, Italy. Our findings indicate that experiential augmentation increased consumers’ WTP for wine. Our results suggest that experiential marketing practices explicitly related to the environment where the wine is produced and consumed can lead to increased valuation for wine.
Modulation of complex coordinated molecular signaling by 5HT and a cocktail of inhibitors leads to ovarian maturation of Penaeus monodon in captivity
Authors: Mani Thiyagu , Subramaniya Bharathi Raja , Chidambaram Iyer Sowmya , Sivasithamparam Niranjali Devaraj , Devaraj Halagowder 
Published: March 2019

AbstractIn aquaculture practices, prawn cultivation holds the major share and Penaeus monodon is the main species cultured. The decline in production of P. monodon is mainly due to the limited availability of domesticated broodstock, which is attributed to its reproductive cycle, controlled by complex coordinated signaling mechanisms. Unilateral eyestalk ablation of domesticated females held in captivity is done to induce ovary development, which has certain disadvantages, including a high rate of mortality. Thus, developing alternative techniques for eyestalk ablation in captive broodstock is necessary to induce maturation of ovary. This study exemplifies the role of 5HT along with a cocktail of inhibitors (U0126, Rp‐cAMP, and LY294002) in inducing ovarian maturation. In this study, inhibition of pERK by U0126 inhibited vitellogenesis‐inhibiting hormone (VIH), which in turn led to the overexpression of vitellogenin. 5HT induces steroidogenesis (estradiol‐17β) through induction of the gonadotropin‐releasing hormone by activating calcium–calmodulin signaling. Steroidogenesis is also aided by synthesis of StAR protein. Estradiol‐17β stimulates the formation of the maturation‐promoting factor (MPF) complex by cdc25 activation and Myt1 inactivation. LY294002 aids in keeping cdc25 activated by inhibiting calcium–calmodulin induced phosphorylation of Akt which is a negative regulator of mitogen‐activated protein kinases. VIH induced activation of Myt1, through protein kinase A (PKA), was inhibited by Rp‐cAMP which inhibits adenylate cyclase, thus stabilizing the activated MPF complex. To conclude, the coordinated effect of inhibitors and 5HT accelerates the development of ovary from previtellogenic to matured oocytes, yielding high quality and quantity larvae compared with eyestalk‐ablated P. monodon.
Long‐term ethanol consumption promotes changes in β‐defensin isoform gene expression and induces structural changes and oxidative DNA damage to the epididymis of rats
Authors: Sadeghzadeh Maryam , Shirpoor Alireza , Naderi Roya , Kheradmand Fatemeh , Gharalari Farzaneh H. , Samadi Mahrokh , Khalaji Naser , Gharaaghaji Rasool 
Published: March 2019

AbstractChronic alcohol ingestion causes sexual dysfunction, impairs sperm motility and fertility, and changes semen quality. Considering the key role of epididymis in sperm development, the aim of the present study was to evaluate the effects of long‐term ethanol consumption on epididymis changes, including alterations in β‐defensin isoform gene expression, oxidative stress, and pathological changes, such as cell proliferation and fibrosis in the epididymis of rats. In this study, male Wistar rats were equally divided into control and ethanol (4.5 g/kg BW) groups. After six weeks of treatment, the results revealed the proliferation of epididymis cells, fibrosis in the epididymis tissue, and a significant rise in the level of 8‐OHdG and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in the ethanol group, compared with the control group. Moreover, the ethanol group showed an increase in the gene expression of epididymal β‐defensin isoforms 15 and 21 and a reduction in the gene expression of β‐defensin isoforms 27 and 30, compared with the controls. These findings indicate that ethanol‐induced epididymal damage and sperm abnormalities might be partly associated with changes in β‐defensin isoforms and epididymal structure, mediated by the increased activities of 8‐OHdG and NADPH oxidase.
Diffusion Acceleration with Gaussian process Estimated Reconstruction (DAGER)
Authors: Wu Wenchuan , Koopmans Peter J. , Andersson Jesper L.R. , Miller Karla L. 
Published: March 2019

PurposeImage acceleration provides multiple benefits to diffusion MRI, with in‐plane acceleration reducing distortion and slice‐wise acceleration increasing the number of directions that can be acquired in a given scan time. However, as acceleration factors increase, the reconstruction problem becomes ill‐conditioned, particularly when using both in‐plane acceleration and simultaneous multislice imaging. In this work, we develop a novel reconstruction method for in vivo MRI acquisition that provides acceleration beyond what conventional techniques can achieve.Theory and MethodsWe propose to constrain the reconstruction in the spatial (k) domain by incorporating information from the angular (q) domain. This approach exploits smoothness of the signal in q‐space using Gaussian processes, as has previously been exploited in post‐reconstruction analysis. We demonstrate in‐plane undersampling exceeding the theoretical parallel imaging limits, and simultaneous multislice combined with in‐plane undersampling at a total factor of 12. This reconstruction is cast within a Bayesian framework that incorporates estimation of smoothness hyper‐parameters, with no need for manual tuning.ResultsSimulations and in vivo results demonstrate superior performance of the proposed method compared with conventional parallel imaging methods. These improvements are achieved without loss of spatial or angular resolution and require only a minor modification to standard pulse sequences.ConclusionThe proposed method provides improvements over existing methods for diffusion acceleration, particularly for high simultaneous multislice acceleration with in‐plane undersampling.
Reducing distortions in echo‐planar breast imaging at ultrahigh field with high‐resolution off‐resonance maps
Authors: van Rijssel Michael J. , Zijlstra Frank , Seevinck Peter R. , Luijten Peter R. , Gilhuijs Kenneth G. A. , Klomp Dennis W. J. , Pluim Josien P. W. 
Published: March 2019

PurposeDWI is a promising modality in breast MRI, but its clinical acceptance is slow. Analysis of DWI is hampered by geometric distortion artifacts, which are caused by off‐resonant spins in combination with the low phase‐encoding bandwidth of the EPI sequence used. Existing correction methods assume smooth off‐resonance fields, which we show to be invalid in the human breast, where high discontinuities arise at tissue interfaces.MethodsWe developed a distortion correction method that incorporates high‐resolution off‐resonance maps to better solve for severe distortions at tissue interfaces. The method was evaluated quantitatively both ex vivo in a porcine tissue phantom and in vivo in 5 healthy volunteers. The added value of high‐resolution off‐resonance maps was tested using a Wilcoxon signed rank test comparing the quantitative results obtained with a low‐resolution off‐resonance map with those obtained with a high‐resolution map.ResultsDistortion correction using low‐resolution off‐resonance maps corrected most of the distortions, as expected. Still, all quantitative comparison metrics showed increased conformity between the corrected EPI images and a high‐bandwidth reference scan for both the ex vivo and in vivo experiments. All metrics showed a significant improvement when a high‐resolution off‐resonance map was used (P < 0.05), in particular at tissue boundaries.ConclusionThe use of off‐resonance maps of a resolution higher than EPI scans significantly improves upon existing distortion correction techniques, specifically by superior correction at glandular tissue boundaries.
Increased Diet Quality is Associated with Long‐Term Reduction of Abdominal and Pericardial Fat
Authors: Hennein Rachel , Liu Chunyu , McKeown Nicola M. , Hoffmann Udo , Long Michelle T. , Levy Daniel , Ma Jiantao 
Published: March 2019

ObjectiveThis study examined the longitudinal associations between genetic risk, change in diet quality, and change in visceral adipose tissue (ΔVAT), abdominal subcutaneous adipose tissue (ΔSAT), and pericardial adipose tissue (ΔPAT).MethodsA total of 1,677 Framingham Heart Study participants who had ectopic fat depots measured using computed tomography were analyzed. Diet quality was quantified using a Mediterranean‐style diet score (MDS) and genetic risk by depot‐specific genetic risk scores (GRSs).ResultsPer SD improvement in MDS, there was 50 cm3 (95% CI: 14‐86; P = 0.007) less fat accumulation in VAT, 52 cm3 (95% CI: 12‐92; P = 0.01) less fat accumulation in SAT, and 1.3 cm3 (95% CI: 0.1‐2.4; P = 0.04) less fat accumulation in PAT. No association was observed between GRSs and ΔVAT or ΔSAT. Each 1‐SD increase in the PAT GRS was associated with a 1.2‐cm3 (95% CI: 0.1‐2.3; P = 0.03) increase in ΔPAT. In participants with higher PAT GRS, those with ΔMDS ≥ 0 had a favorable change in PAT compared with the counterparts with ΔMDS < 0 (P = 0.008).ConclusionsLongitudinal improvements in diet quality are associated with less ectopic fat accumulation. This study suggests that diet quality may play a critical role in improving ectopic adiposity profiles.
Rothia mucilaginosa bacteremia: A 10‐year experience of a pediatric tertiary care cancer center
Authors: Poyer Fiona , Friesenbichler Waltraud , Hutter Caroline , Pichler Herbert , Dworzak Michael , Peters Christina , Mann Georg , Indra Alexander , Attarbaschi Andishe 
Published: March 2019

AbstractRothia mucilaginosa is part of the oral and upper respiratory tract flora. Usually, this gram‐positive coccus is not pathogenic; however, in the setting of immunosuppressed hosts, it can cause life‐threatening infections as an opportunistic pathogen. Among a cohort of 1511 hematologic‐oncologic patients at a pediatric tertiary care cancer center, we identified five cancer patients (0.35%) within a period of 10 years having a proven Rothia mucilaginosa bacteremia (1 culture positive: n = 3/5; > 1 culture positive: n = 2/5). With prompt and adequate antibiotic treatment, infection resolved rapidly before recovery of neutrophils and without any sequelae, suggesting that Rothia mucilaginosa bacteremia without organ involvement is not exceptionally problematic in pediatric cancer patients.
Endosomal pH favors shedding of membrane‐inserted amyloid‐β peptide
Authors: Shi Jing‐Ming , Lv Jian‐Min , Gao Bo‐Xuan , Zhang Lin , Ji Shang‐Rong 
Published: March 2019

AbstractAmyloid‐β peptides (Aβs) are generated in a membrane‐embedded state by sequential processing of amyloid precursor protein (APP). Although shedding of membrane‐embedded Aβ is essential for its secretion and neurotoxicity, the mechanism behind shedding regulation is not fully elucidated. Thus, we devised a Langmuir film balance‐based assay to uncover this mechanism. We found that Aβ shedding was enhanced under acidic pH conditions and in lipid compositions resembling raft microdomains, which are directly related to the microenvironment of Aβ generation. Furthermore, Aβ shedding efficiency was determined by the length of the C‐terminal membrane‐spanning region, whereas pH responsiveness appears to depend on the N‐terminal ectodomain. These findings indicate that Aβ shedding may be directly coupled to its generation and represents an unrecognized control mechanism regulating the fate of membrane‐embedded products of APP processing.
Differential response to neoadjuvant hormonal therapy in prostate cancer: Predictive morphological parameters and molecular markers
Authors: Wang Xueli , Qi Mei , Zhang Jing , Sun Xiubin , Guo Hongwei , Pang Yu , Zhang Qian , Chen Xinyi , Zhang Ruifeng , Liu Zhiyan , Liu Long , Hao Xiaomeng , Han Bo 
Published: March 2019

ObjectivesThe predictive value of the histological parameters and molecular markers for neoadjuvant hormonal therapy (NHT) in prostate cancer (PCa) has not been well established. The aim of this study is to determine pathological variables that can predict differences in response to NHT in PCa.MethodsA total of 85 locally high risk PCa patients with matched preoperative needle biopsies and radical prostatectomy (RP) specimens were included. All patients were treated with NHT for at least 3 months. We quantified the response to NHT using a new proposed pathological grading system. The system classified tumors into five groups (grades 0‐4) according to the severity of histological response. We then categorized the PCa patients into drug‐sensitive (DS) group (Grades 2‐4) and drug‐resistant (DR) group (Grades 0‐1). Two pathologists assessed each pretreated tumors for presence or absence of nine morphological features. The expression of androgen receptor (AR), ERG, and PTEN were evaluated by immunohistochemistry (IHC) as well. Statistical analysis was performed to identify significant associations between differentially histological response to NHT and morphological features as well as molecular aberrations. We evaluated different prediction models using receiver operating characteristic (ROC) curves and area under the ROC curve (AUC) analysis.Results73% (n = 62/85) of tumors in our cohort belonged to DS group, whereas 27% (n = 23/85) of tumors were DR. Univariate logistic analysis suggested four pathological variables, cribriform growth pattern, macronucleoli, ductal adenocarcinoma differentiation, and PTEN loss in needle biopsies were significantly associated with DR effect, all with P‐value < 0.05. Multivariate logistic regression analysis revealed that the three parameters as significant predictive factors for predicting DR effect. These were macronucleoli (RR = 4.008, P = 0.002), ductal adenocarcinoma differentiation (RR = 11.659, P = 0.009) and PTEN loss expression (RR = 7.275, P = 0.015). The AUC of three integrated indicators model was 0.781.ConclusionsOur study suggested that the presence of tumor cribriform growth pattern, macronucleoli, ductal adenocarcinoma differentiation, and PTEN loss in needle biopsies are of value in predicting tumor response to NHT regimen. Multivariate logistic regression analysis revealed the performance of combined pathological indicators in predicting DR response was better than that of model based on individual factor alone.
Feasibility of deep learning for predicting live birth from a blastocyst image in patients classified by age
Authors: Miyagi Yasunari , Habara Toshihiro , Hirata Rei , Hayashi Nobuyoshi 
Published: March 2019

AbstractPurposeTo identify artificial intelligence (AI) classifiers in images of blastocysts to predict the probability of achieving a live birth in patients classified by age. Results are compared to those obtained by conventional embryo (CE) evaluation.MethodsA total of 5691 blastocysts were retrospectively enrolled. Images captured 115 hours after insemination (or 139 hours if not yet large enough) were classified according to maternal age as follows: <35, 35‐37, 38‐39, 40‐41, and ≥42 years. The classifiers for each category and a classifier for all ages were related to convolutional neural networks associated with deep learning. Then, the live birth functions predicted by the AI and the multivariate logistic model functions predicted by CE were tested. The feasibility of the AI was investigated.ResultsThe accuracies of AI/CE for predicting live birth were 0.64/0.61, 0.71/0.70, 0.78/0.77, 0.81/0.83, 0.88/0.94, and 0.72/0.74 for the age categories <35, 35‐37, 38‐39, 40‐41, and ≥42 years and all ages, respectively. The sum value of the sensitivity and specificity revealed that AI performed better than CE (P = 0.01).ConclusionsAI classifiers categorized by age can predict the probability of live birth from an image of the blastocyst and produced better results than were achieved using CE.
Quantitative estimates and extrapolation for multilinear weight classes
Authors: Nieraeth Zoe 
Published: March 2019

AbstractIn this paper we prove a quantitative multilinear limited range extrapolation theorem which allows us to extrapolate from weighted estimates that include the cases where some of the exponents are infinite. This extends the recent extrapolation result of Li, Martell, and Ombrosi. We also obtain vector-valued estimates including $$\ell ^\infty $$

ℓ
∞

spaces and, in particular, we are able to reprove all the vector-valued bounds for the bilinear Hilbert transform obtained through the helicoidal method of Benea and Muscalu. Moreover, our result is quantitative and, in particular, allows us to extend quantitative estimates obtained from sparse domination in the Banach space setting to the quasi-Banach space setting. Our proof does not rely on any off-diagonal extrapolation results and we develop a multilinear version of the Rubio de Francia algorithm adapted to the multisublinear Hardy–Littlewood maximal operator. As a corollary, we obtain multilinear extrapolation results for some upper and lower endpoints estimates in weak-type and $${{\,\mathrm{BMO}\,}}$$

BMO

spaces.
Epistemic norms, closure, and No-Belief hinge epistemology
Authors: Simion Mona , Schnurr Johanna , Gordon Emma 
Published: March 2019

AbstractRecent views in hinge epistemology rely on doxastic normativism to argue that our attitudes towards hinge propositions are not beliefs. This paper has two aims; the first is positive: it discusses the general normative credentials of this move. The second is negative: it delivers two negative results for No-Belief hinge epistemology such construed. The first concerns the motivation for the view: if we’re right, doxastic normativism offers little in the way of theoretical support for the claim that our attitudes towards hinge propositions are anything but garden-variety beliefs. The second concerns theoretical fruitfulness: we show that embracing a No-Belief view will either get us in serious theoretical trouble, or loose all anti-sceptical appeal.
The Relationship between Marijuana Use Prior to Sex and Sexual Function in Women
Authors: Lynn Becky K. , López Julia D. , Miller Collin , Thompson Judy , Campian E. Cristian 
Published: March 2019

Abstract

Introduction
Scientific research on the effects of marijuana on sexual functioning in women, including libido, arousal, orgasm, and satisfaction, is limited.

Aim
To evaluate women’s perceptions of the effect of marijuana use before sexual activity.

Methods
A cross-sectional design, from March 2016–February 2017, within a single, academic, obstetrics and gynecology practice, was performed. Patients were given a questionnaire at their visit and asked to complete it anonymously and place it in a locked box after their visit.

Main Outcome Measures
The primary outcome was satisfaction in the sexual domains of drive, orgasm, lubrication, dyspareunia, and overall sexual experience. The secondary outcome was the effect of the frequency of marijuana use on satisfaction.

Results
Of the 373 participants, 34.0% (n = 127) reported having used marijuana before sexual activity. Most women reported increases in sex drive, improvement in orgasm, decrease in pain, but no change in lubrication. After adjusting for race, women who reported marijuana use before sexual activity had 2.13 higher odds of reporting satisfactory orgasms (adjusted odds ratio = 2.13; 95% CI = 1.05, 4.35) than women who reported no marijuana use. After adjusting for race and age, women with frequent marijuana use, regardless of use before sex or not, had 2.10 times higher odds of reporting satisfactory orgasms than those with infrequent marijuana use (adjusted odds ratio = 2.10; 95% CI = 1.01–4.44).

Conclusion
Marijuana appears to improve satisfaction with orgasm. A better understanding of the role of the endocannabinoid system in women is important, because there is a paucity of literature, and it could help lead to development of treatments for female sexual dysfunction.
Conceptual and detailed design knowledge management in customized production – Industrial perspective
Authors: Pokojski Jerzy , Oleksiński Konrad , Pruszyński Jarosław 
Published: March 2019

AbstractThe current market situation forces companies that deal with small scale, dedicated production to meet the needs and demands of their customers quickly. Usually, the products must be designed to fulfil a certain set of requirements. Additional conditions necessary to meet are also the limitations resulting from law regulations related to environmental, safety, maintenance and recycling matters. The imposed requirements are very often contradictory. In such cases the design process is an attempt to find a rational compromise. Fulfilling all the above-mentioned conditions is very difficult, especially for small companies. As the result, engineers have to take into consideration a much wider scope of tasks and responsibilities which are related to different areas of knowledge. Knowledge of a particular area is not always mastered to the extent that allows them to move freely within it. In such situations engineers are willing to use personal knowledge and experiments as the basic sources of design information. The exchange of opinions, joint evaluation of concepts and detailed solutions, as well as long-term and short-term close teamwork are also often observed. Public tools to support the indicated processes did not fully meet the team's requirements. The authors introduce a proposal for an application that supports the solving of this class problem based on modelled, acquired and stored knowledge. The work presents the characteristics and range of supported engineering processes. Next, the concept and the construction of the software, as well as its functioning using real examples, which derive from industrial practice, are presented.Highlights Manufacturers of industrial equipment must be flexible in relation to customer requirements. Designers need to take into account a much wider range of knowledge than in the past. Engineers are willing to use techniques such as re-use and modification. The aim of work is to create software solutions that will streamline the design phase. The authors create an environment where knowledge and its development is the main aspect.