bluuebunny/crossref_metadata_2025_split huggingface dataset:
¿Cómo explorar el ambiente sonoro donde ocurre el aprendizaje del lenguaje oral? Una propuesta para obtener indicadores de medida.
Authors: Espinoza Zúñiga Cristian Rodrigo , Osses Bustingorry Sonia Eliana , Gálvez Nieto Jose Luis 
Published: July 2019

El desarrollo del lenguaje oral, ocurre en el íntimo espacio de los hogares humanos, en esta etapa el ambiente acústico cobra especial relevancia, ya que las señales sonoras en interacción con el lenguaje intersubjetivo, van modelando el lenguaje hablado. Actualmente diversas circunstancias han modificado algunas características en las estructuras de cuidado parental; la escucha a través de reproductores, y la implementación de instituciones escolares desde los primeros meses hacen necesario profundizar en este fenómeno. Se encuentra evidencia de que la brecha generada en cuanto a tiempos del aprendizaje del lenguaje, es muy difícil de revertir para los sistemas educacionales. Es necesario mencionar que interacciones proto-musicales presentan relación con los mecanismos que activan los procesos en esta etapa. Este trabajo presenta una propuesta para conocer y medir el ambiente sonoro donde ocurre el desarrollo del lenguaje, desde la percepción de los habitantes, dado que existe imposibilidades técnicas y éticas para acceder a este hábitat. Se identificaron 10 factores presentes, y se creó una escala mixta de calificaciones sumadas con ítemes de tipo 'psicofísico' y 'likert'. Se describe a continuación el proceso de construcción y validación de este instrumento, utilizando análisis factorial, análisis de fiabilidad, y correlación con datos del ambiente obtenidos con un 'analizador de espectro audible Phonic PAA (RTA)'. Se aplicó el instrumento a 316 padres de niños no lectores, y se encontró mediante correlaciones bi-variadas entre los factores, evidencia de que el ambiente sonoro tiene influencia en los hábitos y actitudes relacionadas con el mismo.
Gobierno de los jueces. La Corte Constitucional de Colombia y la “segunda reelección presidencial
Authors: Ferreyra Raúl Gustavo 
Published: July 2019

En el presente trabajo se analiza el “constitucionalismo ciudadano” que inteligentemente comporta una inequívoca elección por el gobierno del Derecho que emana de la Ley fundamental del Estado. Se desarrolla en el sistema jurídico colombiano la relación entre la ciudadanía y el poder judicial en un caso de interpretación de la Constitución Política de Colombia, y se profundiza en la sentencia de su Corte Constitucional que dictó una decisión judicial obturando la segunda reelección presidencial de Álvaro Uribe Vélez, al resolver declarar inexequible en su totalidad la Ley 1354 de 2009, por siete votos contra dos. Se califica a esta decisión judicial como una de las resoluciones que, en el inventario general, puede ser computada como de las más relevantes que se han pronunciado en la historia de la jurisdicción de la América del Sud. El constitucionalismo ciudadano, un cultivo abnegado de la Ley fundamental, alumbra la factibilidad de una participación determinante e inclusiva de cada ser humano en la búsqueda y afirmación de una ciudadanía plena. La sentencia en análisis significa un verdadero contrapeso, una especie de “gobierno de los jueces” demoledor e injustificado. Ella misma, con afán de constitucionalidad, negó y prohibió el instrumento racional y pacífico de reforma, el sufragio de los ciudadanos que integran el pueblo, único presupuesto ontológico del Derecho constitucional. Contra la emergencia que produjo “la sentencia” se ensaya esta tesis, cuyas proposiciones capitales se construyen y justifican, en todo el recorrido de este estudio, con las propias piezas de la Ley fundamental colombiana de 1991.
A meta-analysis of impact of low-flow/low-gradient aortic stenosis on survival after transcatheter aortic valve implantation
Authors: Takagi Hisato , Hari Yosuke , Kawai Norikazu , Kuno Toshiki , Ando Tomo 
Published: July 2019

Aims
To determine whether low-flow/low-gradient (LF/LG) aortic stenosis affects survival after transcatheter aortic valve implantation (TAVI), we performed a meta-analysis of currently available studies.

Methods
MEDLINE and EMBASE were searched through January 2019 using PubMed and OVID. Observational studies comparing all-cause mortality after TAVI for patients with classical LF/LG (C/LF/LG) aortic stenosis versus normal-flow/high-gradient (NF/HG) aortic stenosis, paradoxical LF/LG (P/LF/LG) aortic stenosis versus NF/HG aortic stenosis, and (3) C/LF/LG aortic stenosis versus P/LF/LG aortic stenosis were included. Study-specific estimates, risk and hazard ratios of mortality, were combined in the random-effects model.

Results
Our search identified nine eligible studies including a total of 5512 TAVI patients. Pooled analysis demonstrated significantly higher early mortality in C/LF/LG aortic stenosis than NF/HG aortic stenosis (risk ratio, 1.72; P = 0.02) and no statistically significant difference in early mortality between P/LF/LG aortic stenosis and NF/HG aortic stenosis (P = 0.67) and between C/LF/LG aortic stenosis and P/LF/LG aortic stenosis (P = 0.51). Midterm mortality in C/LF/LG (risk ratio/hazard ratio, 1.73; P = 0.0003) and P/LF/LG aortic stenosis (risk ratio/hazard ratio, 1.48; P < 0.0001) was significantly higher than that in NF/HG aortic stenosis. There was no statistically significant difference in midterm mortality between C/LF/LG aortic stenosis and P/LF/LG aortic stenosis (P = 0.63).

Conclusion
After TAVI, C/LF/LG aortic stenosis is associated with increased early mortality compared with NF/HG, and C/LF/LG and P/LF/LG aortic stenosis is associated with increased midterm mortality compared with NF/HG aortic stenosis despite no difference in early mortality between P/LF/LG aortic stenosis and NF/HG aortic stenosis. There is no difference in early and midterm mortality between C/LF/LG aortic stenosis and P/LF/LG aortic stenosis.
Clinical and biological implications of Hippo pathway dysregulation in sarcomas
Authors: Kyriazoglou Anastasios , Zakopoulou Roubini , Zagouri Flora , Bamias Aristotelis , Dimopoulos Meletios Athanasios 
Published: July 2019

Abstract
Sarcomas are mesenchymal malignant tumors with poor prognosis and limited treatment options. Hippo pathway is a recently discovered pathway normally involved in organ development and wound healing. Hippo signaling is often altered in solid tumors. The molecular elements of Hippo signaling include MST1/2 and LATS1/2 kinases which phosphorylate and regulate the activity of YAP and TAZ co-transcriptional activators. Hippo pathway cross-talks with several molecular pathways with known oncogenic function. In sarcomas Hippo signaling plays a pivotal role in tumorigenesis, evolution and resistance in chemotherapy regimens. Targeting Hippo pathway could potentially improve prognosis and outcome of sarcoma patients.
The Portrait of Noken As A Manifestation of The Existence of Papuans
Authors: Syufi Yafed , Budiarsa Made , Simpen I Wayan , Sri Satyawati Made 
Published: July 2019

The Portrait of Noken as a manifestation of the Existence of Papuans is seen from the perspective of the socio-cultural aspect, Noken, as a manifestation of the indigenous Papuan representation in its mandate, is only vague but its meaning is very deep. Its meanings can be both denotative and connotative. For example, the Noken called mesin, as a medium of transporting various types of goods, has a denotative meaning. In addition, it also has a connotative meaning, namely a person who is open and likes giving whatever he/she has in his/her Noken. The next connotative meaning is as a mother who carries the burden of life or as it is usually called ifaj uk aromat mowran (a women carrying a lot of burden), starting from the period of menstruation, conceiving, giving birth and breastfeeding, which is identical to a Noken called mesin. Unlike the case of Noken, which is called mecoi, this kind of Noken has two kinds of meanings, namely denotatively as a means of transporting goods and connotatively as a person who is closed or stingy. Both mesin and mecoi are used for reducing the amount of garbage that has been wrapped around the life of the nation and the state.
DINAMISASI DAN PRODUKTIVITAS PRIMER SUNGAI CITARUM PROVINSI JAWA BARAT
Authors: Suprabawati Anggi , Hardian Arie , Al Ghifari Eki 
Published: July 2019

Monitoring the quality of the river is essentially to know the status of the periodic quality of the river. Good assessment of river water quality should use a combination of physical, chemical and biological parameters. One way that can be done to describe water quality in an area is the primary productivity in the water. Primary productivity is the amount of organic material produced by autotrophic organisms with the help of sunlight. Perifiton as a river microorganism, will provide dissolved oxygen (DO) through photosynthesis to maintain most of the life of the surrounding water, then Periphyton can respond quickly to environmental changes, this is an indicator of changing conditions (Gaiser 2008 and Lakewatch, 2000) in Brown and Wright (2016) Chemical reactions that occur in the aquatic environment also involve interactions between ions and other phases. Some important interactions in the waters are the occurrence of photosynthesis by algae and the exchange of dissolved solids with dissolved gases in water. The same exchange occurs when bacteria degrade organic matter (often in the form of particles) in water. Some important elements move around in aquatic systems as colloidal chemical compounds or are absorbed into soil particles. The equilibrium of physical chemical reactions in waters involves sediment, gas, and water. Sediment is a layer of material or material that covers the bottom of small rivers, lakes, reservoirs, bays, and oceans. Sediments contain fine mixtures and subtle minerals, including clay, silt, and sand, which mix with organic materials. These materials may experience changes in composition from pure mineral ingredients to main organic ingredients. Sediments contain biological ingredients, chemicals, and pollutants in water.
Keywords: Primary Productivity; citarum river ; sediment; water test parameter
Additional Utility of Pharmacogenomics (PGx) Panel Testing in a CYP2D6 Normal Metabolizer with a History of Breast Cancer
Authors: Schuh Michael 
Published: July 2019

Objective: To demonstrate the utility of pharmacogenomic (PGx) panel testing use versus single gene testing for a single indication. Panel testing may not only help further refine clinical decision making for the primary medical indication, it may uncover with one diagnostic test multiple PGx abnormalities, altering current and future therapy for other conditions.
Summary: Breast cancer patient presented to the pharmacist PGx service to discuss results and to help determine best guidance for post-surgical pain treatment. From the panel testing it was incidentally found the patient may be at higher clot risk from standard cancer prophylactic, hormone therapy as well as possible future cardiac therapy.
Conclusion: PGx panel testing may not only uncover potential medication related problems (MRPs) with the primary medical indication being tested, it may also refine therapy for other medical problems, resulting in avoidance of future MRPs and the health care costs associated with them.

Article Type: Case Study
Rancang Bangun Aplikasi Game Edukasi Koleksi Permainan Aksara Lampung (Koper Apung) Berbasis Android Menggunakan Metode Scrum
Authors: Nama Gigih Forda , Pamungkas Ayu Dian , Mardiana Mardiana , Septama Hery Dian 
Published: July 2019

<p class="Abstrak">Indonesia merupakan negara yang memiliki keanekaragaman budaya. Salah satu bentuk keragaman budayanya adalah bahasa daerah yang berbeda di setiap wilayah. Bahkan, pada beberapa daerah tertentu memiliki aksara khusus dalam penulisan, salah satunya yaitu aksara Lampung. Ada berbagai macam cara yang biasa dilakukan untuk melestarikan penggunaan aksara dan bahasa daerah, salah satunya dengan memanfaatkan teknologi. Penelitian ini menghasilkan sebuah produk <em>game</em> edukasi belajar bahasa dan aksara Lampung (KOPER APUNG) berbasis android dengan metode <em>scrum</em> dan menggunakan <em>game</em> <em>engine</em> c<em>onstruct</em> 2. Dari 3 kali proses iterasi <em>sprint</em> yang dilakukan, menghasilkan sebuah <em>game</em> edukasi yang sesuai dengan kebutuhan pengguna. Pengujian <em>portability</em> menunjukkan bahwa <em>game</em> dapat berjalan pada perangkat android minimum versi 4.1. Pengujian <em>functionality</em> menunjukkan aset <em>game</em> 100% dapat berjalan baik. User <em>acceptance</em> <em>test</em> dengan melibatkan 25 responden, menunjukkan predikat sangat baik dengan persentase 95,77%. Pengujian <em>efficiency</em> menunjukkan <em>game</em> menggunakan CPU rata-rata sebesar 15% dan RAM 400 MB. Sedangkan pada tahap evaluasi, tingkat kelulusan responden meningkat dari sebelumnya 36 % menjadi 96%. Sehingga, <em>game</em> ini efektif digunakan sebagai salah satu media belajar Aksara Lampung.</p><p class="Abstrak"> </p><p class="Abstrak"><em><strong>Abstract</strong></em></p><p class="Abstrak"><em>Indonesia is a country with various cultures. One of them is that every region has its own local language as its special characteristic. Some local languages have their own local letters, for example is the Lampungnese letters. There are a lot of techniques to conserve the use of local language and its letters, one of them is by implementing technologies. This Koper Apung (the Collection of Lampungnese Letters Game) Educational Game was created in the form of game application for android based smartphone by using scrum methodology and assisted by Construct 2 Engine. From the sprint result of the scrum methodology, an educational game which adjusted to the needs of the user was established. The result of portability aspect showed that Koper Apung game could work well on the minimally 4.1 version of android appliances. The functionality test showed that all game assets could satisfactorily 100% work. User Acceptance test indicated, Very good‟ predicate with 95.77% result. The efficiency test denoted that this game used 15% CPU and 400 MB RAM. Meanwhile, on the evaluation phase, the respondents‟ level of success improved from 36% to 96%. These signified that the Koper Apung game is an effective and applicable media to learn Lampungnese Letters.</em></p>
Aplikasi Peta Titik Rawan Banjir di Kota Palembang
Authors: Saputri Nurul Adha Oktarini , Halim R.M Nasrul 
Published: July 2019

Banjir merupakan masalah yang terjadi hampir diseluruh kota di Indonesia, tak terkecuali di kota Palembang. Masalah banjir di kota Palembang sudah menjadi masalah yang serius bagi pemerintah kota Palembang. Banjir di kota Palembang terjadi akibat banjir pasang musiman maupun banjir genangan akibat hujan yang sering terjadi di jalanan. Banjir yang terjadi di jalanan, dapat menyebabkan kerusakan terutama kendaraan baik roda dua maupun roda empat. Selain itu banjir juga dapat menyebabkan kemacetan lalu lintas karena kendaraan harus memperlambat kendaraannya agar tidak merusak kendaraan serta tidak menggangu pengendara lain yang melintas. Permasalahan utama dalam penelitian ini adalah tidak adanya aplikasi untuk mengetahui daerah atau jalan mana saja yang berpotensi terjadinya banjir khususnya di kota Palembang. Oleh sebab itu dibutuhkanlah suatu aplikasi dengan memanfaatkan teknologi komunikasi mobile yang dapat memberikan informasi kepada masyarakat, terutama pengguna kendaraan yang sedang berada di jalan agar dapat terhidar dari bencana banjir. Dengan memanfaatkan layanan titik lokasi menggunakan Google Maps dan API, penulis akan membangun sebuah aplikasi berbasis android, yang bertujuan agar dapat memberikan informasi pengguna kendaraan tentang lokasi titik rawan banjir saat terjadi hujan maupun banjir musiman di jalan-jalan kota Palembang, sehingga dapat membantu pengendara menghidari kerusakan kendaraan akibat banjir serta dapat membantu mengurangi kemacetan pada saat terjadinya banjir agar dapat menghemat waktu perjalanan. AbstractFlooding is a problem that happens almost throughout the city in Indonesia, no exception in Palembang city. The problem of flooding in the Palembang city has become a serious problem for the Government. Flooding in Palembang occur due to tidal flooding or flood inundation due to seasonal rains that often occur in the streets. The flooding that occurred on the streets, can cause damage especially two-wheel vehicles or four wheel. In addition to flooding can also cause traffic congestion because the vehicles had to slow down their vehicles so as not to damage the vehicle and does not interfere with other riders crossing. The main problem in this research is the lack of application to know which road areas or potential occurrence of flooding especially in Palembang. Therefore it needs an application by making use of mobile communication technology that can provide information to the public, especially users vehicles that are on the way so it can be terhidar from the flood. By utilizing the service point location using Google Maps and API, the author will build an android-based applications, the aim is to be able to provide information about the location of the point of vehicle users prone to flooding in the event of rain or flood seasonal in the streets of the city of Palembang, so you can help motorists avoid vehicle damage due to flooding and can help reduce congestion at the time of the occurrence of flooding in order to save on travel time.
Visão histórica e fisiológica da interação do leite e do trigo com a microbiota intestinal humana
Authors: Monteiro de Oliveira Cruz Roberta , Cruz Paula Monteiro de Oliveira , Machado Brenda Raiane Cunha , Lucena Taise Cunha de , D’Avila Liohanna Silva Pires , Almeida Taianara Tocantins Gomes 
Published: July 2019

Objetivo: Explanar acerca das alterações do microbioma intestinal humano associadas ao consumo do trigo e leite de vaca. Métodos: Realização de levantamento bibliográfico de artigos científicos publicados de 2001 a 2018 nas plataformas Scielo, Lilacs e Pubmed, utilizando os descritores microbiota intestinal, glúten, trigo e leite. Resultados: A alta exposição ao trigo e ao leite pode ocasionar quadros de disbiose intestinal, como a doença celíaca - que é caracterizada por uma reação inflamatória que leva ao achatamento das microvilodiades intestinais e ao alongamento das células secretoras intestinais, as criptas -, ou mesmo a intolerância à lactose – que é reconhecida pela insuficiência ou ainda total ausência da ação da enzima lactase, impedindo assim a absorção da lactose. Considerações finais: O tratamento nutricional na doença celíaca compreende em uma dieta que restrinja principalmente a ingestão do trigo, enquanto na intolerância à lactose, consiste inicialmente na suspensão da ingestão de leite e derivados, realizando, posteriormente a reintrodução gradativa até uma identificação da quantidade máxima tolerada pelo organismo. Para o controle de ambas as disbioses, a literatura também indica a ingestão de simbióticos, no entanto, à medida que as pesquisas na área da saúde avançam progressivamente, novas descobertas surgirão acerca de tratamentos eficazes.
Analisis Kesalahan Berbahasa Pada Kegiatan Diskusi
Authors: Suryanti  , Lina Tiawati Refa 
Published: July 2019

Penelitian ini bertujuan mendiskripsikan analisis kesalahan berbahasa siswa SMA Negeri 3 Baubau pada kegiatan diskusi kelas. Desain penelitian secara deskriptif kualitatif. Data penelitian analisis kesalahan berbahasa pada kegiatan diskusi kelas berupa penggunaan intonasi/ nada, diksi (pilihan kata), dan struktur kalimat. Hasil penelitian menunjukkan bahwa bentuk analisis kesalahan berbahasa siswa kelas X SMA Negeri 3 Baubau pada kegiatan diskusi kelas adalah penggunan intonasi/ nada yang terdiri atas: intonasi tinggi, intonasi sedang dan intonasi rendah. Penggunaan diksi (pilihan kata) yang terdiri atas: pemakaian kata bersinonim, pemakaian kata denotasi dan konotasi, pemakaian kata-kata atau istilah asing, pemakaian kata populer dan kata kajian, serta pemakaian kata percakapan dan slang. Penggunaan struktur kalimat terdiri atas: penggunaan struktur kalimat wajib dan penggunaan struktur kalimat tak wajib (mana suka). Berdasarkan data yang diperoleh mengenai analisis kesalahan berbahasa siswa kelas X pada kegiatan diskusi kelas, dapat dikatakan bahwa pada penggunaan intonasi terdapat kesalahan berupa intonasi tinggi sebanyak 11, intonasi sedang tidak ada dan intonasi rendah sebanyak 16 kesalahan. Pada penggunaan diksi terdapat kesalahan pada pemakaian kata bersinonim sebanyak 40, pemakaian kata denotasi dan konotasi sebanyak 41, pemakaian kata-kata atau istilah asing sebanyak 14, pemakaian kata populer dan kata kajian sebanyak 3, dan pemakaian kata percakapan dan slang sebanyak 120 kesalahan. Selanjutnya penggunan struktur kalimat terdapat kesalahan berupa struktur kalimat wajib tidak ada, dan pada struktur kalimat tak wajib sebanyak 156 kesalahan.
Penerepan Model Explicit Instruction Terhadap Keterampilan Menulis Teks Deskripsi Siswa SMP
Authors: Lina Tiawati Refa , Dwinitia Suci 
Published: July 2019

Pembelajaran bahasa Indonesia Kurikulum 2013 yang akan dipelajari oleh siswa SMP salah satunya yaitu teks deskripsi. Teks deskripsi adalah jenis teks memaparkan suatu objek, hal dan keadaan sehingga pembaca seolah-olah mendengar melihat, atau merasakan hal yang dipaparkan. Dalam menulis teks deskripsi harus memperhatikan struktur dan kaidah kebahasaan teks deskripsi yang telah ditetapkan, agar menghasilkan suatu teks deskripsi yang padu dan utuh. Di dalam menulis teks deskripsi peserta didik masih mengalami kesulitan dalam penulisan kaidah kebahasaann yang masih kurang. Tujuan penelitian ini adalah untuk mengetahui pengaruh penggunaan model Explicit Instruction terhadap keterampilan menulis teks deskripsi siswa SMP. Jenis penelitian ini adalah penelitian kuantitatif dengan menggunakan metode eksperimen. Desain penelitian ini adalah one group pretets-postest design penelitian ini dilakukan sebanyak dua kali sebelum diberikan perlakuan dan sesudah diberikan perlakuan. Teknik pengambilan sampel penelitian ini dengan teknik purposive sampling, Sampel dalam penelitian ini adalah satu kelas. Data dalam penelitian ini adalah tes unjuk kerja hasil keterampilan menulis teks deskripsi sebelum dan sesudah menggunakan model pembelajaran Explicit Instruction terhadap keterampilan menulis teks deskripsi siswa SMP. Hasil penelitiannya adalah ada pengaruh yang signifikan antara model pembelajaran dengan hasil keterampilan menulis teks berita sebelum dan sesudah menggunakan model Explicit Instruction terhadap Keterampilan Menulis Teks deskripsi Siswa SMP. Hal ini dibuktikan dengan hasil penelitian yang menunjukkan bahwa nilai thitung > ttabel (> 1,90), sehingga H0 ditolak dan H1 diterima. Hal itu berarti model pembelajaran explicit instruction efektif digunakan dalam keterampilan menulis teks deskripsi siswa SMP.
A topofobia em a hora da estrela
Authors: Fonseca Ludmilla Carvalho 
Published: July 2019

Este trabalho tem como objetivo abordar o conceito de topofobia em A Hora da Estrela, de Clarice Lispector, demonstrado através da composição da personagem Macabéa. Na tentativa de capturar a perda das relações humanas, buscou-se mostrar a importância da topofobia na qual Macabéa está inserida. Utilizou-se das concepções: fenomenológica, psicológica e existencial, contida de forma implícita no romance, para discutir o estranhamento ao espaço vivido que Macabéa está submetida.
INGLÊS DE SOUSA: AMAZÔNIA, HISTÓRIA E FICÇÃO
Authors: Leandro Rafael Voigt 
Published: July 2019

Neste artigo, discutimos de que modo entram em tensão dialética a História e a Literatura no conto amazônico O donativo do capitão Silvestre, de Inglês de Sousa. Ao analisar a narrativa, assinalamos como o trabalho estético do narrador de ficção permite aproximar dois acontecimentos históricos aparentemente inconciliáveis: a Questão Christie e a Cabanagem. Nessa direção, refletimos a respeito das relações colônia-metrópole entre Brasil e Inglaterra e da situação marginal da Amazônia dentro da nação brasileira.