bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extensor carpi radialis longus tendon ball interposition arthroplasty for treatment of late-stage Kienböck’s disease: Short-term results of a novel technique
Authors: Aslantürk Okan , Ertem Kadir , Ergen Emre , Köroğlu Muhammed 
Published: October 2018

Purpose: The aim of this study was to evaluate short-term clinical and radiological results of extensor carpi radialis longus (ECRL) tendon ball arthroplasty for treatment of late-stage Kienböck’s disease. Methods: We retrospectively reviewed data of 19 patients suffering from Kienböck’s treated with ECRL tendon ball arthroplasty between December 2014 and December 2016. Patients’ clinical functions were assessed using grip strength, range of motion (ROM) of the wrist, QuickDASH, Mayo wrist score, and visual analog scale score. Radiological examination was performed to assess carpal height ratio and progression of arthritis. Results: The median follow-up was 30 months (range, 12–36 months). At final follow-up, ROM of operated wrist was 71% of the nonoperated side. Thirteen (86.6%) patients were pain free. Carpal height ratio was statistically significantly reduced compared with preoperative values. All patients declared their satisfaction with the results due to their preoperative status. Conclusions: ECRL tendon ball arthroplasty is a new and good option for treatment of late-stage Kienböck’s disease with low complication rate.
Bifunctional PD-1 × αCD3 × αCD33 fusion protein reverses adaptive immune escape in acute myeloid leukemia
Authors: Herrmann Monika , Krupka Christina , Deiser Katrin , Brauchle Bettina , Marcinek Anetta , Ogrinc Wagner Ana , Rataj Felicitas , Mocikat Ralph , Metzeler Klaus H. , Spiekermann Karsten , Kobold Sebastian , Fenn Nadja C. , Hopfner Karl-Peter , Subklewe Marion 
Published: October 2018

AbstractThe CD33-targeting bispecific T-cell engager (BiTE) AMG 330 proved to be highly efficient in mediating cytolysis of acute myeloid leukemia (AML) cells in vitro and in mouse models. Yet, T-cell activation is correlated with upregulation of programmed cell death-ligand 1 (PD-L1) and other inhibitory checkpoints on AML cells that confer adaptive immune resistance. PD-1 and PD-L1 blocking agents may counteract T-cell dysfunction, however, at the expense of broadly distributed immune-related adverse events (irAEs). We developed a bifunctional checkpoint inhibitory T cell–engaging (CiTE) antibody that combines T-cell redirection to CD33 on AML cells with locally restricted immune checkpoint blockade. This is accomplished by fusing the extracellular domain of PD-1 (PD-1ex), which naturally holds a low affinity to PD-L1, to an αCD3.αCD33 BiTE-like scaffold. By a synergistic effect of checkpoint blockade and avidity-dependent binding, the PD-1ex attachment increases T-cell activation (3.3-fold elevation of interferon-γ) and leads to efficient and highly selective cytotoxicity against CD33+PD-L1+ cell lines (50% effective concentration = 2.3-26.9 pM) as well as patient-derived AML cells (n = 8). In a murine xenograft model, the CiTE induces complete AML eradication without initial signs of irAEs as measured by body weight loss. We conclude that our molecule preferentially targets AML cells, whereas high-affinity blockers, such as clinically approved anticancer agents, also address PD-L1+ non-AML cells. By combining the high efficacy of T-cell engagers with immune checkpoint blockade in a single molecule, we expect to minimize irAEs associated with the systemic application of immune checkpoint inhibitors and suggest high therapeutic potential, particularly for patients with relapsed/ refractory AML.
Imaging tumour hypoxia with oxygen-enhanced MRI and BOLD MRI
Authors: O'Connor James P B , Robinson Simon P , Waterton John C 
Published: October 2018

Hypoxia is known to be a poor prognostic indicator for nearly all solid tumours and also is predictive of treatment failure for radiotherapy, chemotherapy, surgery and targeted therapies. Imaging has potential to identify, spatially map and quantify tumour hypoxia prior to therapy, as well as track changes in hypoxia on treatment. At present no hypoxia imaging methods are available for routine clinical use. Research has largely focused on positron emission tomography (PET)-based techniques, but there is gathering evidence that MRI techniques may provide a practical and more readily translational alternative. In this review we focus on the potential for imaging hypoxia by measuring changes in longitudinal relaxation [R 1; termed oxygen-enhanced MRI or tumour oxygenation level dependent (TOLD) MRI] and effective transverse relaxation [R 2*; termed blood oxygenation level dependent (BOLD) MRI], induced by inhalation of either 100% oxygen or the radiosensitising hyperoxic gas carbogen. We explain the scientific principles behind oxygen-enhanced MRI and BOLD and discuss significant studies and their limitations. All imaging biomarkers require rigorous validation in order to translate into clinical use and the steps required to further develop oxygen-enhanced MRI and BOLD MRI into decision-making tools are discussed.
Social and economic impacts of congenital Zika syndrome in Brazil: Study protocol and rationale for a mixed-methods study
Authors: Kuper Hannah , Lyra Tereza Maciel , Moreira Maria Elisabeth Lopes , de Albuquerque Maria do Socorro Veloso , de Araújo Thália Velho Barreto , Fernandes Silke , Jofre-Bonet Mireia , Larson Heidi , Lopes de Melo Ana Paula , Mendes Corina Helena Figueira , Moreira Martha Cristina Nunes , do Nascimento Marcos Antonio Ferreira , Penn-Kekana Loveday , Pimentel Camila , Pinto Marcia , Simas Clarissa , Valongueiro Sandra 
Published: October 2018

Global concern broke out in late 2015 as thousands of children in Brazil were born with microcephaly, which was quickly linked to congenital infection with Zika virus (ZIKV). ZIKV is now known to cause a wider spectrum of severe adverse outcomes—congenital Zika syndrome (CZS)—and also milder impairments. This study aimed to explore the social and economic impacts of CZS in Brazil. Data was collected through mixed methods across two settings: Recife City and Jaboatão dos Guararapes in Pernambuco State (the epicentre of the epidemic), and the city of Rio de Janeiro (where reports of ZIKV infection and CZS were less frequent). Data was collected May 2017-January 2018. Ethical standards were adhered to throughout the research. In-depth qualitative interviews were conducted with: mothers and other carers of children with CZS (approximately 30 per setting), pregnant women (10-12 per setting), men and women of child-bearing age (16-20 per setting), and health professionals (10-12 per setting). Thematic analysis was undertaken independently by researchers from at least two research settings, and these were shared for feedback. A case-control study was undertaken to quantitatively explore social and economic differences between caregivers of a child with CZS (cases) and caregivers with an unaffected child (controls). We aimed to recruit 100 cases and 100 controls per setting, from existing studies. The primary caregiver, usually the mother, was interviewed using a structured questionnaire to collect information on: depression, anxiety, stress, social support, family quality of life, health care and social service use, and costs incurred by families. Multivariable logistic regression analyses were used to compare outcomes for cases and controls. Costs incurred as a result of CZS were estimated from the perspective of the health system, families and society. Modelling was undertaken to estimate the total economic burden of CZS from those three perspectives.
LA IMAGEN CORPORAL Y LA (IN)SATISFACCIÓN ENTRE LOS ESTUDIANTES DE NUTRICIÓN
Authors: Sampaio Helena Alves de Carvalho , Parente Nara De Andrade , Carioca Antônio Augusto , Jiménez Rodríguez Diana 
Published: October 2018

Objetivo: objetivo de este estudio fue evaluar la correlación entre la imagen corporal y las mediciones antropométricas reales y las indicadas como deseadas en alumnos de nutrición como un factor de riesgo potencial para el desarrollo de trastornos de la alimentación. Metodología: Los estudiantes de nutrición de una universidad pública fueron evaluados por antropometría y se les aplicó el cuestionario Body Shape Questionnaire. Resultados: Se encontró una alta prevalencia de peso normal y sin insatisfacción en la imagen corporal (89,5%). Pero sólo 14 (12,3%) estaban satisfechos con su peso. Discussión: Preocuparse demasiado por la imagen y la insatisfacción puede conducir a una baja autoestima, interferencia en sus estudios y em su futura práctica profesional. Conclusión: Aún con la baja prevalencia de insatisfacción en la imagen de sí mismo, esa alta tasa de insatisfacción con el peso actual es preocupante ya que ambos pueden aumentar el riesgo de perturbaciones futuras, una excesiva apreciación de la beleza a costa de la salud y que se refleje en su futura práctica profesional.
Ressonâncias de um grupo na vida das mulheres de um serviço de saúde mental [Resonances of a group in the lives of women in a mental health service] [Resonancias de un grupo en la vida de las mujeres de un servicio de salud mental]
Authors: Rézio Larissa De Almeida , Moraes Priscilla Daleffe de , Fortuna Cinira Magali 
Published: October 2018

Objetivo: analisar as ressonâncias de um grupo na vida das mulheres de um serviço de saúde mental de Mato Grosso. Método: pesquisa descritiva de abordagem qualitativa, realizada com cinco mulheres no período de abril a junho de 2012, por meio de entrevista semiestruturada realizada após a aprovação do Comitê de Ética em Pesquisa. O referencial teórico baseou-se em grupos operativos e na Atenção Psicossocial. Resultados: o grupo de mulheres auxiliou na reinserção social, construção de autonomia e restabelecimento de vínculos sociais e familiares. O grupo homogêneo, quanto ao gênero, facilitou a identificação entre as participantes, desenvolvendo e mantendo vínculos interpessoais, e estimulou a permanência delas no serviço. Conclusão: confirma-se a importância do grupo operativo como instrumento de trabalho na assistência em saúde mental, repercutindo em resultados condizentes com a atenção psicossocial e necessidades do universo feminino.ABSTRACT Objective: to examine how a group resonated in the lives of women attending a mental health service in Mato Grosso state. Method: a descriptive, qualitative approach was applied through semi-structured interviews of five women, from April to June 2012, after approval by the research ethics committee. The theoretical framework was based on operative groups and psychosocial care. Results: the women’s group assisted in social reintegration, autonomy-building, and reestablishing social and family ties. The group’s gender homogeneity helped participants identify, and develop and maintain interpersonal ties, and encouraged them to remain in the service. Conclusion: the study confirmed the operative group’s importance as a working tool in mental health care, where its repercussions aligned with psychosocial care and women’s needs.RESUMEN Objetivo: analizar las resonancias de un grupo en la vida de las mujeres de un servicio de salud mental de Mato Grosso. Método: investigación descriptiva de enfoque cualitativo, realizada junto a cinco mujeres en el período de abril a junio de 2012, por medio de entrevista semiestructurada realizada tras la aprobación del Comité de Ética en Investigación. El referencial teórico se basó en grupos operativos y en la Atención Psicosocial. Resultados: el grupo de mujeres auxilió en la reinserción social, construcción de autonomía y restablecimiento de vínculos sociales y familiares. El grupo homogéneo, en cuanto al género, facilitó la identificación entre las participantes, desarrollando y manteniendo vínculos interpersonales, y estimuló su permanencia en el servicio. Conclusión: se confirma la importancia del grupo operativo como instrumento de trabajo en la asistencia en salud mental, repercutiendo en resultados acordes con la atención psicosocial y necesidades del universo femenino.
Características individuais e comportamentos de autocuidado de graduandos de enfermagem: experiência em oficina sociopoética [Nursing undergraduates’ individual characteristics and self-care behavior: experience in a sociopoetic workshop] [Características individuales y comportamientos de autocuidado de los estudiantes de enfermería: experiencia en taller sociopoético]
Authors: Souza Maria das Graças Gazel de , Santos Iraci Dos , Silva Leandro Andrade da , Silva Alexandre Vicente da , Silva Leonor Coelho da , Cunha Adriana Loureiro da 
Published: October 2018

Objetivo: identificar as características individuais e comportamentais de enfermagem, em oficinas sociopoéticas. Metodologia: estudo descritivo, sociopoético e estatístico, desenvolvido após aprovação do Comitê de Ética em Pesquisa, com graduandos de enfermagem em Curso de Autocuidado, aplicando formulário em entrevista coletiva. Participaram 20 acadêmicos de enfermagem de universidade pública no Rio de Janeiro, Brasil, entre abril e maio de 2015. Resultados: a maioria é do sexo feminino, na faixa etária dos 20 aos 25 anos, de etnia branca, protestante e com renda familiar de quatro salários mínimos e residem com os pais; são solteiros e sem filhos; apenas um declarou ter comportamentos integrados de autocuidado. Conclusão: a maioria não aplica a concepção de integralidade no autocuidado, privilegiando a higiene corporal.ABSTRACTObjective: ito identify the individual characteristics and self-care behavior of nursing undergraduates in sociopoetic workshops. Methodology: this statistical, descriptive, sociopoetic study was conducted, after approval by the research ethics committee, by applying a form at a group meeting of twenty nursing students from a public university in Rio de Janeiro, Brazil, between April and May 2015. Results: most were female, single and childless, aged 20-25 years, white, Protestant, with family income of four minimum wages and lived with their parents, and only one reported integrated self-care behavior. Conclusion: most did not apply the concept of comprehensiveness to self-care, but favored body hygiene.RESUMEN Objetivo: identificar las características individuales y comportamientos de enfermería, en oficinas sociopoéticas. Método: estudio descriptivo, sociopoético y estadístico, desarrollado después de la aprobación del Comité de Ética en Investigación, con estudiantes de enfermería en Curso de Autocuidado, aplicando formulario en entrevista colectiva. Participaron 20 estudiantes de enfermería de universidad pública en Río de Janeiro, Brasil, entre abril y mayo de 2015. Resultados: la mayoría es de sexo femenino, entre 20 y 25 años, de etnia blanca, protestante y con ingresos familiares de cuatro salarios mínimos y que viven con sus padres; son solteros sin hijos; solo uno declaró que tiene comportamientos integrados de autocuidado. Conclusión: la mayoría no aplica la concepción de integralidad en el autocuidado y privilegia la higiene corporal.
Pelo avesso: dialogando sobre a Teoria Fundamentada nos Dados [By avenue: dialoging about Grounded Theory] [Al revés: dialogando sobre la Grounded Theory]
Authors: Solano Lorrainy Cruz , Miranda Francisco Arnoldo Nunes de , Enders Bertha Cruz , Sousa Francisca Georgina Macedo de 
Published: October 2018

Objetivo: refletir sobre a Teoria Fundamenta nos Dados (TFD) ou Grounded Theory, como recurso metodológico para pesquisas qualitativas em enfermagem. Conteúdo: utilizou-se como base para a discussão o diálogo entre autores convergentes com os pressupostos da TFD que caminham pelo avesso do roteiro metodológico clássico da pesquisa qualitativa. Duas linhas argumentativas foram desenhadas para que a reflexão acontecesse: a primeira a partir do método TFD propriamente dito e a segunda sobre os saberes na pesquisa em enfermagem. Conclusão: a atual conjuntura impõe o compromisso do pesquisador de enfermagem com as necessidades de saúde da população e com o Sistema Único de Saúde, requerendo estratégias de enfrentamento dos problemas viáveis, eficazes, eficiente e resolutivas. A TFD é uma delas, instigando o conhecimento do conhecimento em enfermagem.ABSTRACT Objective: to think about Grounded Theory as a methodological resource for qualitative research in nursing. Content: the discussion was based on dialogue among authors who converge with the assumptions of Grounded Theory, which run counter to the classic methodological script of qualitative research. Two lines of argument were traced for the thinking to take place: the first based on the Grounded Theory method as such, and the second on knowledge in nursing research. Conclusion: the current situation demands that nursing researchers commit to the population’s health needs and the Unified Health System, and requires feasible, effective, efficient problem-solving strategies, of which Grounded Theory is one, instigating knowledge of knowledge in nursing.RESUMENObjetivo: reflexionar sobre la Grounded Theory como recurso metodológico para investigaciones cualitativas en enfermería. Contenido: se utilizó como base para la discusión o el diálogo entre autores convergentes con los supuestos de la Grounded Theory que caminan al revés del guion metodológico clásico de la investigación cualitativa. Se dibujaron dos líneas argumentativas para que la reflexión ocurriera: la primera desde el método Grounded Theory propiamente dicho y la segunda sobre los saberes en la investigación en enfermería. Conclusión: la actual coyuntura impone el compromiso del investigador de enfermería respecto a las necesidades de salud de la población y al Sistema Único de Salud, y requiere estrategias de afrontamiento de problemas factibles, eficaces, eficientes y resolutivos. La Grounded Theory es una de ellas e instiga el conocimiento de los saberes de enfermería.
FAMÍLIA, ESCOLA E PESSOA COM DEFICIÊNCIA
Authors: Fernandes Ana Paula Cunha dos Santos 
Published: October 2018

objetiva-se analisar a relação família-escola na formação da pessoa com deficiência a partir das concepções dos professores. Como a família e a escola contribuem na formação da pessoa com deficiência? Configura-se como pesquisa qualitativa, e seguiu o seguinte delineamento: levantamento bibliográfico, entrevistas semiestruturada, sistematização e análise dos dados. O estudo foi realizado com coordenadores pedagógicos, professores de sala de aula comum e sala de recursos multifuncional, em cinco escolas e duas unidades pedagógicas de Belém. Sobre os resultados: em algumas escolas a família participa das reuniões com os professores de SRM à parte da escola, e, em outras, não comparece e alega falta de condição financeira; uma professora destaca a questão da violência.
COMPLEXA RELAÇÃO ENTRE FORMAÇÃO CONTINUADA E AVALIAÇÃO EXTERNA NA REDE PÚBLICA DE ENSINO
Authors: Carvalho Ana Carolina Medeiros Gatto Vieira , Varani Adriana 
Published: October 2018

Apresentamos uma reflexão sobre sentidos produzidos da relação entre os programas de formação continuada da rede oficial de Ensino do Estado de São Paulo e avaliação externa a partir de discursos de professores de um município deste estado. A reflexão dos dados pode inferir que a relação entre avaliação externa e formação de professores tem prejudicado essas ações ao longo dos anos, por enfatizar as disciplinas cobradas no SARESP e priorizar as temáticas que compõem as provas, num processo de performatividade, pautando-se em Ball. Os discursos dos professores nos mostram a complexidade dos posicionamentos no cotidiano escolar e nos levam a refletir sobre as contradições existentes, entre o desejo de ter autonomia do trabalho e a aceitação de avaliações regulatórias e responsabilizadoras.
Early vocational rehabilitation for patients with spinal injury: a qualitative research study of service providers
Authors: Ramakrishnan Kumaran , Murphy Gregory , Middleton James , Cameron Ian 
Published: October 2018

Background/Aims: Early intervention is among the factors frequently associated with positive vocational rehabilitation outcomes. However, vocational rehabilitation is not generally a core component of inpatient rehabilitation for individuals with spinal cord injury, who traditionally have poor vocational outcomes. This study explored the perceptions of vocational coordinators providing early and integrated vocational rehabilitation services in the inpatient hospital settings and their opinions regarding the structures and processes of the interventions. Methods: All the four vocational coordinators involved in providing early integrated vocational services at the three spinal units in New South Wales, Australia were interviewed (in-depth) as key informants using a semi-structured approach. Transcripts of the interviews were created via audio recordings, transcribed verbatim, and the contents were analysed thematically. Findings: Many benefits were seen for vocational coordinators working within a multidisciplinary team in the hospital settings chiefly providing and promoting vocationally oriented therapy. Timing of service provision was not the overarching issue given the optional and voluntary nature of the intervention. The counselling role was seen as eminent given the challenging and (occasionally confronting) nature of working with newly injured individuals. Conclusions: The key nature of service provision being patient-centred and paced, within the context of a supportive spinal cord injury rehabilitation team, seemed to engender much hope and optimism, which are salient for newly injured individuals with spinal cord injury in the hospital setting.
Effects and feasibility of virtual reality system vs traditional physical therapy training in multiple sclerosis patients
Authors: Streicher Matthew C , Alberts Jay L , Sutliff Matthew H , Bethoux Francois 
Published: October 2018

Background/Aims: Traditionally, physical therapy for gait and balance training takes place in a gym setting, which may not fully reproduce situations in everyday activities. The Computer Assisted Rehabilitation ENvironment system provides an immersive virtual environment, allowing a simulation of complex conditions conducive to gait and balance training. The purpose of this study was to determine: (1) the feasibility and safety of using the Computer Assisted Rehabilitation ENvironment system for physical therapy sessions with multiple sclerosis patients, and (2) pre-post treatment changes observed with the Computer Assisted Rehabilitation ENvironment system compared to traditional physical therapy. Findings: Data from functional outcome measures Berg Balance Scale, Timed Up and Go test, Timed 25-Foot Walk, and 6-Minute Walk Test were extracted from the medical records of 62 patients with multiple sclerosis who had at least three physical therapy sessions in either environment. Statistically significant within-group improvements were observed for all outcome measures in the physical therapy Computer Assisted Rehabilitation ENvironment system group (P<0.05), and only for Berg Balance Scale in the traditional physical therapy group. There was a significant between-group difference in favour of physical therapy with the Computer Assisted Rehabilitation ENvironment system for the Timed 25-Foot Walk (P=0.022). Conclusions: The results suggest the Computer Assisted Rehabilitation ENvironment system is a safe and effective tool for physical therapy-led gait and balance training for individuals with multiple sclerosis.