bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROFILE IGA (VCA-P18+EBNA1) AND VIRAL LOAD EBV DNA AS A RISK FACTOR AMONG RELATIVES OF NASOPHARYNX CARCINOMA PATIENT WITH EBV POSITIVE AT DR. WAHIDIN SUDIROHUSODO HOSPITAL IN MAKASSAR
Authors: Pieter Nova Audrey Luetta 
Published: October 2019

Introduction:
Nasopharyngeal carcinoma (NPC) is closely associated to viral infection, i.e. Epstein-Barr virus (EBV), about 90 % of the worldwide are infected with EBV at same point of their lives. This virus is highly oncogenic and easily transmitted via saliva. The high level of biomarker for EBV infection can become a risk factor for NPC in relative’s NPC patients. Therefore, EBV related biomarkers is needed to enable screening and detecting early diagnosis of NPC in endemic area.
Objective:
This study aims to analyze the role of IgA (VCA-p18+EBNA1) levels and viral load (VL) as screening tools for early detection in relatives of positive EBV NPC patients. Therefore, it can be used as predicted risk factor for NPC.
Method:
The method used in this study is cross-sectional with consecutive sampling of 50 relatives of NPC patients treated at the Dr. Wahidin Sudirohusodo Hospital from August 2012 to May 2013. Univariate and bivariate analysis and t-test are used to measure and to show the correlation of Ig A (VCA-p18+EBNA1) level and VL.
Result:
Results showed that 28 % of the NPC patients are female with an average age of 31.12±11.91. Sixty-eight percent of the relatives are siblings, and most of them are Buginese tribe (58%). According to the risk distribution of NPC, the sampling is grouped in 3 categories i.e. high risk, intermediate risk, and low risk to NPC. There is 50% of the relatives of the NPC patients categorized to the intermediate risk. The IgA (VCA-p18+EBNA1) level is significant (p=0.000) compared with the VL level (p=0.337). Sixteen percent of the high-risk group have a normal pattern, but it still needs high awareness. Statistically, the Pearson correlation analysis showed a relationship but not significant.
Conclusion:
It could be concluded that IgA (VCA-p18+EBNA1) and VL level could be used as a screening method and early detection in relatives of NPC patients and become a predicted risk factor for NPC
THE RELATION OF EBNA-1 AND EGFR EXPRESSION SCREENING FROM ADVANCED STAGE UNDIFFERENTIATED NASOPHARYNGEAL CANCER
Authors: Prabowo Imam , Zuliyanto Agus , Setiamika Made , Sudrajad Hadi , Anggraini Aulia Hervi , Budiani Dyah Ratna , Cornain Santoso , Nasar Made , Oyong  
Published: October 2019

Introduction:
Nasopharyngeal carcinoma (NPC) is a lymphoepithelial malignancy of the nasopharynx, one of the etiologies is the infection of Epstein–Barr virus in undifferentiated type of nasopharyngeal carcinoma. The Epstein-Barr virus Nucleus Antigen-1 (EBNA-1) is Epstein–Barr virus-encoded proteins as regulatory virus transcription. Epithelial Growth Factor Receptor (EGFR) consist of a single polypeptide chain of amino acid, ErbB members, tyrosine kinase receptor, a transmembrane glycoprotein encoded by gen location in the short arms of a chromosome and overexpression in epithelial tumors. EGFR plays a central role in signal transduction pathways which regulate key cellular functions in epithelial malignancies. and may also present in NPC.
Objective:
To investigate this relation of expression patterns of EBNA-1 and EGFR in a histological type of undifferentiated nasopharyngeal carcinoma.
Method:
Observational, analytical study with a cross-sectional method of 34 formalin-fixed within inclusion criteria are EBNA-1 and positive staining of EGFR expression (30 patients) and exclusion criteria of negative staining of EGFR (4 patients). All biopsy samples work with paraffin embedded and resulted in hematoxylin-eosin undifferentiated histological types of the advanced stage in nasopharyngeal carcinoma. EBNA-1 and EGFR expression used immunohistochemistry staining.
Result:
EBNA-1 and EGFR expression level were detection and correlated with the advanced stadium of nasopharyngeal undifferentiated carcinoma.
Conclusion:
EBNA-1 is significantly related to EGFR expression in the advanced stadium of undifferentiated nasopharyngeal carcinoma. Overexpression of EGFR is mostly found in advanced NPC but not in all ages. Male is dominated and overall age below 55 years old. Screening of EGFR with immunohistochemistry is highly considered before anti-EGFR treatment
KAJIAN TINGKAT KEPUASAN PELANGGAN TERHADAP KINERJA TRANSPAKUAN BOGOR (Studi kasus: Pelayanan di Halte dan Pelayanan di dalam Bus Transpakuan Bogor)
Authors: Savitri Aris , Murtejo Tedy , . Rulhendri 
Published: October 2019

<p>Kepuasan pelanggan adalah perasaan senang atau kecewa pelanggan yang berasal dari perbandingan antara kesannya terhadap kinerja atau hasil suatu produk dan harapan-harapannya. pengukuran kinerja merupakan alat atau metode yang digunakan untuk memberikan penilaian<br />seberapa besar tingkat prestasi kerja atau capaian tujuan dan sasaran yang telah ditentukan. Bus Tran s Pakuan kota Bogor adalah bus rapit transit di kota Bogor, yang diresmikan pada tanggal 3 Juni 2007 melayani Koridor Cidangiang-Bubulak, Koridor Cidangiang– Harjasari,<br />Koridor Cidangiang-Bellanova dan lain-lain. Analisis dilakukan dengan metode Customer Satisfaction Index dan didapat karakteristik penumpang Trans Pakuan Bogor didominasi oleh wanita (52%), usia antara 18-28 tahun (54,3%), jenis pekerjaan adalah pelajar/mahasiswa (47,9%), status keluarga belum bekeluarga (62,4%), dan pendapatan &lt; Rp. 1.000.000 (34,6%).<br />Dari metode Customer Satisfaction Index didapat kepuasan dan kepentingan pelanggan terhadap kinerja Trans Pakuan Bogor dalam pelayanan Halte diperoleh nilai sebesar 48% (di antara 35,00% - 50,99%) bahwa menandakan pengguna kurang merasa puas terhadap<br />tingkat standard pelayanan halte dan tingkat kepuasaan pelanggan terhadap pelayanan di dalam Bus diperoleh nilai sebesar 51% (di antara 51% - 65,99%) menunjukan bahwa menandakan pengguna cukup puas terhadap tingkat standard pelayanan bus. Analisis ini juga<br />menggunakan metode Importance-Satisfaction Analysis yaitu dengan membandingkan kinerja Transpakuan Bogor berdasakan metode Importance-Satisfaction Analysis menunjukkan bahwa<br />aspek yang perlu dipelihara pada Pelayanan Halte adalah Aksebilitas, fasilitas penutup halte, fasilitas penerangan, kenyamanan tempat duduk, fasilitas kebersihan dll dan Pada Pelayanan di<br />dalam Bus adalah waktu operasional bus, kenyamanan didalam bus, petugas keamanan, fasilitas pegangan tangan, akses turun naik disabilitas.</p>
KAJIAN STRUKTUR BANGUNAN AKIBAT PENURUNAN MUTU BETON PADA KOLOM TERPASANG (Studi Kasus: SDN 01 Cikaret Kabupaten Bogor)
Authors: Lutfi Muhamad , . Subton 
Published: October 2019

<p>Bangunan sekolah selayaknya harus memenuhi persyaratan teknis yang telah ditetapkan dan diatur didalam Undang- undang Bangunan Gedung No. 28 Tahun 2002 bahwa setiap gedung harus memiliki asas kemanfaatan, keselamatan, kenyamanan dan keserasian dengan lingkungannya. SDN 01 Cikaret tengah melakukan rehabilitasi bangunan namun pada pelaksanaannya ditemukan kondisi dimana beton mengalami perubahan fisik yaitu berupa<br />pelapukan hal itu diduga terjadi akibat penurunan mutu beton pada kolom tersebut, dengan demikian akan menyebabkan kolom menjadi rusak dan daya dukung kolom serta kekuatan struktur bangunan sekolah akan berkurang. Pengujian mutu beton akan dilakukan dengan cara <br />uji tanpa merusak dengan hammer test sehingga akan didapat nilai mutu beton yang terdapat pada bangunan, nilai dari hammer test itu kemudian dianalisis dengan menggunakan softwere Etabs dengan memperhitungkan berat beban yang harus diterima oleh bangunan baik itu beban hidup, beban mati, dan beban gempa, yang kemudian dikombinasikan dan<br />dianalisis kembali secara manual sehingga diperoleh hasil dimana warna merah yang muncul pada permodelan di semua struktur bangunan kemudian dengan hitungan manual didapatkan hasil dengan diagram interaksi kolom dimana nilai R (pertemuan garis Pu dan Mu) berada diluar diagram interaksi kuat rencana, setelah itu dilakukan perencanaan ulang dengan menggunakan<br />mutu beton K-225 diperoleh hasil dimana dengan permodelan softwere Etabs ditunjukkan dengan warna ungu yang berarti struktur aman dan hitungan manual dengan diagram interaksi<br />kolom hasil dimana nilai R (pertemuan garis Pu dan Mu) berada didalam diagram interaksi kuat rencana. Sehingga dapat disimpulkan bahwa kolom pada bangunan eksisting sudah tidak dapat<br />menahan beban bangunan diatasnya sedangkan dengan perencanaan mutu beton K-225 struktur kolom mampu menahan beban struktur ditasnya</p>
STUDI KELAYAKAN INVESTASI FINANSIAL (Studi Kasus: Perumahan BIA Residence)
Authors: Natasasmita Ginanjar , Murtejo Tedy , Chayati Nurul , Lutfi Muhamad 
Published: October 2019

<p>Bekasi merupakan salah satu kota yang berkembang dalam dunia properti pembangunan perumahan, menurut BPS Kota Bekasi jumlah penduduk Jatimurni Kec. Pondokmelati ditahun 2017 ±155.407 jiwa, PT. Bina Infra Antarnusa selaku developer akan membangun sebuah perumahan<br />komersil. Perumahan ini diberi nama BIA Residence yang terletak dijalan Pabuaran, Jatimurni, Pondokmelati, Kota Bekasi, Jawa Barat. Dengan luas tanah yang ada ±1170 . Perumahan BIA<br />Residence dibangun khusus bagi masyarakat menengah kebawah, tapi tidak menutup kemungkinan bagi masyarakat umum memiliki rumah di perumahan BIA Residence. Mengingat dana yang dibutuhkan cukup besar dalam jangka waktu yang panjang, maka perlu dilakukan penyusunan studi<br />kelayakan investasi secara cermat dan tepat untuk menghindari resiko kerugian di masa yang akan datang dan sebagai pedoman dalam pengambilan keputusan apakah proyek perumahan BIA Residence dapat berjalan sesuai dengan yang direncanakan atau tidak. Upaya yang dapat dilakukan<br />dengan posisi wilayah yang strategis adalah untuk mendapatkan hasil analisis studi kelayakan proyek pembangunan Perumahan BIA Residence ditinjau dari aspek teknis dan aspek finansial. Hasil yang <br />diperoleh dari aspek teknis dengan luasan tanah yang ada ±1170 direncanakan jumlah rumah sebanyak 10 unit dengan type 45/80 sebanyak 2 unit, type 45/84 sebanyak 6 unit, dan type 57/96 sebanyak 2 unit. Dari hasil aspek finansial menggunakan metode NPV didapat nilai sebesar<br />Rp94.547.544,21,(NPV&gt;0) maka proyek perumahan BIA Residence layak dijalankan dengan tingkat suku bunga 15% per tahun, dari metode IRR menggunakan suku bunga 10%-30% didapat hasil 22%<br />dengan nilai MAAR 15%, maka IRR 22%&gt;MARR 15% layak untuk dijalankan, tingkat suku bunga lebih besar dari pada MARR.</p>
ANALISIS KINERJA KEUANGAN PADA BANK BERDASARKAN RASIO LIKUIDITAS, SOLVABILITAS DAN RENTABILITAS
Authors: . Supramono , Suharti Titing , Retno Indriati Anissih 
Published: October 2019

<p>Laporan Keuangan Bank dibuat sesuai dengan sistem keuangan yang berlaku agar mampu menunjukan kondisi dan posisi keuangan yang sesungguhnya. Dari laporan ini akan terbaca bagaimana kondisi bank yang sesungguhnya termasuk kelemahan dan kekuatan yang dimiliki bank<br />tersebut. Penelitian ini bertujuan untuk mengetahui tingkat dan kinerja Rasio Likuiditas, Rasio Slovabilitas, dan Rasio Rentabilitas pada sektor Bank yang terdaftar di BEI pada tahun 2012-2017. Adapun populasi dalam penelitian ini yaitu perusahaan perbankan yang terdaftar di Bursa Efek<br />Indonesia dengan sampel metode sampling purposive, jumlah sampel sebanyak tiga perusahaan. Berdasarkan hasil penelitian menunjukkan bahwa Kinerja rasio likuiditas pada Bank Danamon Tbk. Bank Maybank Tbk. Bank CIMB Niaga Tbk. Selama periode 2012-2017 dengan quick ratio,<br />investing policy ratio dan cash rastio dinyatakan likuid karena memiliki rata-rata nilai dengan minimum giro diatas 5%. Kinerja ratio solvabilitas pada Bank Danamon Tbk. Bank Maybank Tbk.<br />Bank CIMB Niaga Tbk. pada tahun 2012-2017 dengan primary ratio, Risk Asset Ratio dan Secondary Risk Ratio dinyatakan solvable. Kinerja rasio rentabilitas pada Bank Danamon Tbk pada tahun 2012-2017 dengan gross profit margin, net profit margin, dan return on equity dinyatakan<br />profitable.</p>
PERAN OTORITAS JASA KEUANGAN DALAM MENGAWASI PINJAMAN BERBASIS TEKNOLOGI INFORMASI (FINTECH LENDING)
Authors: Bimo Widhi Ariyo , Tiyansyah Alvin 
Published: October 2019

<p>Pinjaman memiliki peranan untuk memenuhi kebutuhan baik konsumsi, usaha, maupun pengembangan suatu proyek pekerjaan. Namun semakin majunya industri keuangan saat ini yang melahirkan pinjaman berbasis teknologi informasi atau yang disebut fintech lending yang memberikan kemudahan layanan, namun dibalik pesatnya pertumbuhan fintech lending, semakin<br />banyak pula pihak-pihak yang mendirikan fintech lending illegal yang dapat merugikan masyarakat. Maka dari itu Otoritas Jasa Keuangan memiliki peranan penting dalam mengatur jalannya jasa layanan pinjaman berbasis teknologi ini supaya dapat mencegah tindakan kerugian pada masyarakat.Adapun data hasil penelitian ini langsung didapatkan dengan cara terjun langsung di<br />tempat praktik kerja lapangan yang dilakukan di Otoritas Jasa Keuangan kantor regional 01 DKI Jakarta &amp; Banten, adapun data tersebut menyangkut tentang syarat ketentuan pendirian perusahaanpinjam-meminjam berbasis teknologi, prosedur pendaftaran &amp; perizinan perusahaan pinjam<br />meminjam berbasis teknologi informasi, mekanisme pinjam meminjam berbasis teknologi informasi, dan mekanisme pengawasan otoritas jasa keuangan mengawasi perusahaan pinjam meminjam<br />berbasis teknologi</p>
An Ensemble Co-Evolutionary based Algorithm for Classification Problems
Authors: Trường Vũ Văn , Lâm Bùi Thu , Trung Nguyễn Thành 
Published: October 2019

In this paper, the authors propose a dual-population co-evolutionary approach using ensemble learning approach (E-SOCA) to simultaneously solve both feature subset selection and optimal classifier design. Different from previous studies where each population retains only one best individual (Elite) after co-evolution, in this study, an elite community will be stored and calculated together through an ensemble learning algorithm to produce the final classification result. Experimental results on standard UCI problems with a variety of input features ranging from small to large sizes shows that the proposed algorithm results in more accuracy and stability than traditional algorithms.
Effect of Multi-site Variabilities on Electrovestibulography: Environmental and Physical Factors
Authors: Lithgow Brian , Moussavi Zahra 
Published: October 2019

Background: There are physiological changes in pathologies such as Alzheimer’s Disease (AD) within the lower vestibuloacoustic system, which may be potentially useful when used as neurodegeneration features. We hypothesize two Electrovestibulography feature types (Field Potential (FP) shape and the Firing pattern of detected FP’s) may have utility as Neurodegeneration features. Our long term objective is to use a population of Parkinson’s Disease (PD), AD, Post-Concussion Syndrome (PCS), Bipolar Disorder (BD) and Major Depressive Disorder (MDD) patients together with individual pathology-wise age and gender matched control cohorts to determine the degree to which each of these pathologies varies from controls and in proportion to the level of Neurodegeneration often associated (either temporarily or permanently) with each pathology. However, before such a comparison can be made it is necessary to ensure the various populations recorded across different countries are comparable. This paper determines which populations are comparable.
Methods: An initial comparison of AD (with N = 16) and a best matched healthy control population (with specific age/gender/recording site/electrode matched controls) from a pool of 112 controls produced two EVestG features (FP shape and FP firing pattern). These features were examined for their variability with respect to electrode type, age, gender, powerline frequency and environmental factors.
Results: Age and gender did not have a significant impact on the features. Powerline and environmental artefacts could be accounted for by filtering; thus, they did not significantly affect the features measured. However, electrode type had a significant effect on the extracted features.
Conclusions: For the two EVestG features tested only electrode type had a significant effect on the recordings, and hence the extracted features. Thus, only populations with the same electrode type can be compared.
The Performances of Multiple Scoring Systems to Predict Patients Required Immediate Life-Saving Intervention in Emergency Department
Authors: Tangkulpanich Panvilai , Uppariputtanggoon Noraset , Aramvanitch Kasamon 
Published: October 2019

Background: Crowding in emergency room is the major problem especially in the resuscitation room. Many patients require immediate life-saving interventions (LSI). Whereas, many different scoring systems such as national early warning score (NEWS), worthing physiological scoring system (WPS), modified early warning score (MEWS), and rapid emergency medicine score (REMS) have been developed for assessing patients at risk.
Objective: To evaluate the effectiveness of 4 scoring systems performance in predicting LSI use in emergency room and reenter to the resuscitation room within 48 hours.
Methods: Data were collected by a retrospective cross-sectional study of patients treated in the resuscitation room for 2 months period, at Ramathibodi Hospital. The number of patients who received LSI and reentry to resuscitation room were studied, compared by selected scoring systems.
Results: Total 839 patients entered resuscitation room, while 331 (39.45%) patients received LSI. The first three groups at risk were metabolic diseases, gastrointestinal systems, and infections, respectively. The most effective scoring system in predicting patients required LSI was MEWS, the discrimination of this system was significantly better than NEWS (AUC, 0.69 vs 0.65; 95% CI, 0.65 - 0.72; P = .01). Eighty-six patients (13.89%) from 619 patients reentered to the resuscitation room. Moreover, NEWS was the most effective in predicting patients who had a risk of reenter (AUC, 0.72; 95% CI, 0.66 - 0.78; P < .001).
Conclusions: MEWS is the most effective scoring system for patient assessment of LSI utilization. However, NEWS is the one suitable for predicting reenter tendency.
Tobacco Use and Domestic Violence in Thailand: Matching Case-Control Study
Authors: Ha-upala Araya , Chotivitayataragorn Somporn , Kongsakon Ronnachai 
Published: October 2019

Background: Tobacco dependence is not only a major health risk which can be prevented, but also is a starting point to use other substances and domestic violence.
Objective: To study the association between tobacco use and domestic violence in Thai families.
Methods: The study was designed as a matched case-control study in women aged 15 years and over, living in households across the country, both in urban and rural areas, in 9 provinces of Thailand. The total of 600 participants were included in this study which half of them are from domestic abused families while the other half are from nonabused families. The criteria of age, education, economic status, housing area and region were determined. Differences between groups were performed using chi-square test and t test.
Results: Domestic violence families (55.7%) used tobacco as compared to 42% of families without violence who hadn’t used tobacco. The tobacco used families were significantly having more domestic violence 1.63 times (95% CI 1.17 - 2.29) than non-tobacco used families.
Conclusions: This study showed that tobacco used in the families were more likely to have domestic violence than non-used families. This could raise awareness on tobacco used to create campaigns to reduce the rate of tobacco used which causes domestic violence.
The Urgency of the Maqāṣid Al-Syarī‘Ah in Reasoning Islamic Law
Authors: Alimuddin  
Published: October 2019

This paper aims to present several theories about how important to understand maqāṣid al-syarī‘ah when someone wants to study a law in Islam, someone cannot be separated from that context. Maqāṣid al-syarī‘ah is a barometer or the main standard of consideration in the formulation of shari'ah with the aim of benefit the Ummah, and Islam consistently makes maqāṣid al-syarī‘ah in all its rules. The thinking of Ibn ‘Āsyūr about maqāṣid is built on this principle, that it’s imperative to accept the concept of ta‘līl. The theory of maqāṣid rests on three basic concepts; (a). Maqāṣids are sometimes qath‘ī and ḍannī (assumptive). (b). Maqāṣid ‘āmmah and khaṣṣhah (c). Al-maqām, al-istiqrā ’and distinguish between waṣilah and purpose in the application of fiqh law. Every phenomenon that has great potential for maslahah it can be stated to be included in the maqāṣid al-syarī‘ah. On the other hand the human need is not to know the maqāṣid al-syāri‘ itself, but to find a law for a new case that has no prescribed text. Ontology of maqāṣid al-syarī'at al-khāssah is also a value, because knowing the law for that case is complete with the text, now the needed for a new case, so the ontology of maqāṣid al-syarī'ah in this dimension is a transcendent value to refer when conducting tahqīqal-manāt.
Minimum Marriage Age: Study of Fiqh of Four Madhabs
Authors: Maisarah  , Afrizal  , Zulfahmi  , Mauliza Fizal , Murni Faisal 
Published: October 2019

Fiqh of four madhab (Hanafi, Maliki, Shafi'i and Hambali) permit the marriage of minors, so that parents tend to marry their children at an underage. This ppinion is criticized in modern times who want a minimum age of marriage. The question arises how the interpretation of the four madhab (Islamic jurisprudence) of thought is used and are there other arguments that can be used in reinterpreting the existence of a minimum age of marriage. This study uses some methods, firstly, to examine the verses and hadith to find out whether there are cues about the minimum age of marriage or not. Secondly, to reinterpret using the ta‘liliyyah method and the termiyyah of the arguments used by the religious and contemporary scholars. The result shows that the madhab declares Surah al-Thalaq as the proposition regarding the ability of marriages of young children. According to the author, the logic is incorrect because there is no need to iddah for virgin women contained in Surah al-Ahzhab verse 49; The religious scholars also use it as the proposition of the Prophet's marriage hadith. with ‘Aisha r.a when she was a child, even though this incident occurred in Mecca before the Muslim period and before the hadith about the guardian's obligation to ask permission for a girl or widow. This study also finds other verses that can be used as arguments in limiting the age of marriage, namely Surat al-Nisa 'verses 5-6 and 9, the hadith of Ibn Mas'ud and maslahah to be achieved from a marriage, which explicitly states that both adult and maturity both physically and mentally as a condition of marriage.