bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered intrinsic neural activity and its molecular analyses in first-episode schizophrenia with auditory verbal hallucinations
Authors: Wang Ziyu , Xue Kangkang , Kang Yimeng , Liu Zijun , Cheng Jingliang , Zhang Yan , Wei Yarui 
Published: October 2024

BackgroundAuditory verbal hallucinations (AVHs) are one of the signature positive symptoms of schizophrenia, affecting a substantial portion of patients with schizophrenia. These hallucinations seriously impact the lives of patients, resulting in a substantial social burden. Recent studies have shown a significant correlation between abnormal local brain activity and the neurobiological mechanisms of AVHs. However, it is not fully clear whether altered intrinsic brain activity in schizophrenia patients with AVHs is correlated with specific neurotransmitter systems.MethodsWe included 50 first-episode, drug-naïve schizophrenia patients with AVHs, 50 patients without AVHs (NAVHs), and 50 age- and sex-matched healthy controls (HCs). The amplitude of low-frequency fluctuation (ALFF) was utilized to explore the altered intrinsic brain activity in the AVH group. Subsequently, we spatially correlated the altered ALFF with neurotransmitter maps using JuSpace.ResultsIn our study, compared to HCs, the AVH group exhibited significantly reduced ALFF in multiple brain regions, mainly including the left precuneus, bilateral supplementary motor areas, bilateral paracentral lobules, bilateral precentral gyri, and bilateral postcentral gyri. The NAVH group showed significantly reduced ALFF in the left inferior occipital gyrus, left calcarine gyrus, and left lingual gyrus compared to HCs. Furthermore, the AVH group showed higher ALFF in the right inferior frontal gyrus compared to the NAVH group. Additionally, these ALFF alterations in the AVH group were closely related to three neurotransmitters, including dopamine, serotonin and norepinephrine.ConclusionWe link neurotransmitters to abnormal intrinsic brain activity in first-episode, drug-naïve schizophrenia patients with AVHs, contributing to a comprehensive understanding of the pathophysiological processes and treatment pathways underlying AVHs.
Patterns of expression of VEGFR2, PDGFRs and c-Kit in pediatric patients with high grade non-rhabdomyosarcoma soft tissue sarcoma
Authors: Mohammed Mona M. , Hafez Hanafy A. , Elnadi Enas M. , Salama Asmaa I. , Abd Elaziz Abd Elaziz Saad , Ahmed Gehad T. , ELwakeel Madeeha A. , Kamal Mohamed K. , Kieran Mark W. , Elhaddad Alaa M. 
Published: October 2024

IntroductionActivated vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and c-Kit have been shown to be involved in the growth, invasion and metastasis of non-rhabdomyosarcoma soft tissue sarcoma tumor (NRSTS) with promising results for targeted therapy. Our aim was to assess the expression of these markers among different histological types and correlate with outcomes.Material and methodsThis retrospective study included pediatric patients aged ≤ 18 years diagnosed with high-grade NRSTS who were treated at Children Cancer Hospital Egypt 57357 as per the COG NRSTS protocol (ARST0332). Expression of VEGFR2, PDGFRs (α and β) and c-Kit in tumor tissue was assessed by immunohistochemistry and correlated with clinical outcome.ResultsOf 113 patients, 96 were eligible for the analysis with a median age of 11 years. Overall, 32.3% demonstrated high expression of PDGFRα, 17.7% for PDGFRβ, 19.8% for VEGFR2 and 8.3% exhibited positive expression for c-kit on the tumor cells. Most cases of synovial sarcoma (45.8%) and 43.7% of patients with undifferentiated sarcoma exhibited high expression of PDGFRα while 41.6% of MPNST showed high expression to PDGFRβ. The 5-year overall survival (OS), event free survival and relapse free survival (RFS) for the whole cohort were 59%, 54% and 60% respectively. In univariate analyses, only PDGFRα had a negative prognostic impact on relapse free survival (RFS) (p=0.03). In multivariate analyses, VEGFR2 was found to have a negative prognostic impact for OS (p = 0.02).ConclusionOur findings indicated that tyrosine kinase receptors are upregulated in NRSTS and exhibited a distinct expression pattern within various subgroups. High expression of VEGFR2 and PDGFRα significantly correlated with reduced survival and may guide targeted therapy approaches for this poor prognosis group of patients.
Relationship between physical exercise and college students’ social adaptation: the chain mediating role of self-esteem and peer attachment
Authors: Zhou Zehui , Guo Kelei , Guo Siqiang , Chen Lang 
Published: October 2024

ObjectivePhysical exercise is an important way for college students to keep healthy, and social adaptation is an important part of college students’ mental health. Therefore, this study explores strategies to enhance college students’ social adaptation from the perspective of physical exercise, examining the correlation between physical exercise and college students’ social adaptation, and delving into the roles of self-esteem and peer attachment in this relationship.MethodsA stratified cluster sampling method was used to collect data from 809 college students at Zhaoqing University (average age 19.88 ± 1.22, of whom 399 were male and 410 were female) using the physical exercise scale, college students’ social adaptation scale, self-esteem scale, and peer attachment scale. For data analysis, Pearson correlation analysis, structural equation modeling, and bias-corrected percentile bootstrap methods were sequentially performed.Results(1) Physical exercise was positively correlated with college students’ social adaptation (r = 0.58, p &lt; 0.01), and the direct path between physical exercise and college students’ social adaptation was significant (β = 0.28, p &lt; 0.01, CI[0.22, 0.33]); (2) Physical exercise was positively correlated with self-esteem (β = 0.56, p &lt; 0.01, CI[0.50, 0.62]) and peer attachment (β = 0.18, p &lt; 0.01, CI[0.11, 0.26]); self-esteem was positively correlated with peer attachment (β = 0.36, p &lt; 0.01, CI[0.28, 0.43]) and college students’ social adaptation (β = 0.43, p &lt; 0.01, CI[0.37, 0.49]); peer attachment was positively correlated with college students’ social adaptation (β = 0.18, p &lt; 0.01, CI[0.12, 0.23]); (3) The relationship between physical exercise and social adaptation was not only mediated independently by self-esteem and peer attachment, but also indirectly by the same two factors in a chain reaction.ConclusionPhysical exercise can not only directly predict college students’ social adaptation, but also indirectly predict college students’ social adaptation through the independent mediation and chain mediation of self-esteem and peer attachment. It reveals that we should combine more important physical exercise with mental health education for students.
Material and social deprivation associated with public health actual causes of death among older people in Europe: longitudinal and multilevel results from the Survey of Health, Ageing and Retirement in Europe (SHARE)
Authors: Belau Matthias Hans 
Published: October 2024

BackgroundAdverse socioeconomic conditions at the individual and regional levels are associated with an increased risk of mortality. However, few studies have examined this relationship using multilevel analysis and, if so, only within a single country. This study aimed to examine this relationship using data from several European countries.MethodsIndividual-level data were obtained from Waves 5 to 9 of the Survey of Health, Ageing and Retirement in Europe, while regional-level data were obtained from the Luxembourg Income Study Database. Cox regression analysis with gamma-shared frailty and a random intercept for country of residence was used to examine the association between individual mortality from all causes, cancer, heart attack, and stroke and measures of socioeconomic deprivation at the individual level, including material and social deprivation indices, and at the area level, including the Gini index.ResultsThe risk of mortality from all causes was increased for respondents with material deprivation (hazard ratio (HR) = 1.77, 95% CI = [1.60, 1.96]) and social deprivation (HR = 7.63, 95% CI = [6.42, 9.07]) compared with those without. A similar association was observed between individual deprivation and the risk of mortality from cancer, heart attack, or stroke. Regional deprivation had a modest contextual effect on the individual risk of death from all causes and cancer. However, when individual-level deprivation was included in the models, no contextual effects were found.ConclusionThe results indicate that individual socioeconomic conditions significantly predict causes of death in older European adults, with those with material deprivation and social deprivation having a higher risk of death from all causes, including cancer, heart attack, and stroke, while the Gini index has a minimal effect, although the Gini index reflects regional disparities across Europe.
Effects of two non-drug interventions on pain and anxiety in the nursing process of burn patients: a literature review with meta-analysis
Authors: Zhang Wei , Sui Xiaona , Zhang Lingling , Zhang Liping , Yan Huilan , Song Shuangshuang 
Published: October 2024

BackgroundBurns are a global health issue causing significant mortality and high medical costs. Non-pharmacological interventions such as music therapy and virtual reality (VR) therapy have shown potential in alleviating pain and anxiety in burn patients. This study systematically evaluates the impact of these interventions using a network meta-analysis.MethodsA systematic review and network meta-analysis were conducted according to PRISMA 2020 guidelines and registered in PROSPERO (CRD42024566536). Searches in PubMed, Cochrane Library, Web of Science, and Embase up to November 22, 2023, identified randomized controlled trials (RCTs) involving music therapy or VR therapy in burn patients. The Cochrane Risk of Bias Tool (2.0) assessed study quality. Data were analyzed using StataMP-64 software.ResultsSeventeen RCTs with 1,119 burn patients were included. Both music therapy and VR therapy significantly reduced pain and anxiety compared to control groups. Music therapy was more effective for pain reduction (SUCRA: 85.4%), while VR therapy was superior for anxiety relief (SUCRA: 79.5%).ConclusionMusic therapy and VR therapy effectively reduce pain and anxiety in burn patients. Integrating these interventions into burn care can enhance patient outcomes. Further research is needed to confirm these findings and optimize individualized treatment plans.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, PROSPERO (CRD42024566536).
Preferences for pre-exposure prophylaxis delivery among HIV-negative pregnant and breastfeeding women in Zambia: evidence from a discrete choice experiment
Authors: Hamoonga Twaambo Euphemia , Mutale Wilbroad , Igumbor Jude , Bosomprah Samuel , Arije Olujide , Chi Benjamin H. 
Published: October 2024

IntroductionPregnant and breastfeeding women at substantial risk for HIV infection in sub-Saharan Africa can benefit from biomedical interventions such as pre-exposure prophylaxis (PrEP). We estimated the benefit that pregnant and breastfeeding women may derive from PrEP service delivery in order to guide PrEP roll-out in the target population in Zambia.MethodsBetween September and December 2021, we conducted a discrete choice experiment (DCE) among a convenient sample of 389 pregnant and breastfeeding women not living with HIV in Lusaka, Zambia. Women aged 18 years or older, with a documented negative HIV result in their antenatal card responded to a structured questionnaire containing 12 choice sets on service delivery attributes of PrEP: waiting time at the facility, travel time to the facility dispensing PrEP, location for PrEP pick-up, health care provider attitude and PrEP supply at each refill. Mixed logit regression analysis was used to determine the participant's willingness to trade off one attribute of PrEP for the other at a 5% significance level. Willingness to wait (WTW) was used to determine the relative utility derived from each attribute against waiting time.ResultsWaiting time at the facility, travel time to the facility, health care provider attitude and amount of PrEP supply at each refill were important attributes of PrEP service delivery (all p &lt; 0.01). Participants preferred less waiting time at the facility (β = −0.27, p &lt; 0.01). Women demonstrated a strong preference for a 3-months’ supply of PrEP (β = 1.69, p &lt; 0.01). They were willing to wait for 5 h at the facility, walk for more than an hour to a facility dispensing PrEP, encounter a health care provider with a negative attitude in order to receive PrEP enough for 3 months.ConclusionPatient-centered approaches can help to inform the design and implementation of PrEP services among pregnant and breastfeeding women. In this study, we found that a reduction in clinic visits—including through multi-month dispensing of PrEP—could improve uptake of services in antenatal and postnatal settings.
How do rest-pause and sarcoplasma stimulating training models affect metabolic and psychoaffective responses in bodybuilding athletes compared to traditional training?
Authors: Almeida Gustavo P. L. , João Gustavo A. , Charro Mário A. , de Jesus Santana Wilian , da Silva Carlos Eduardo Rosa , Bocalini Danilo S. , Caperuto Érico C. , Figueira Aylton J. 
Published: October 2024

IntroductionStrength training (ST) is a strategy to enhance quality of life through increased strength, muscle hypertrophy, and functional capacity. Training systems are associated with manipulation of volume and intensity, generating different stimuli, such as Rest-Pause (RP) and Sarcoplasmic Stimulating Training (SST). These systems induce greater mechanical and physiological stress, leading to increased strength and muscle hypertrophy. However, the metabolic and psycho-affective effects of advanced systems in experienced practitioners remain inconclusive. The purpose of the study is to analyze the acute effects of RP, SST, and Traditional (TMS) systems on metabolic and psycho-affective responses in adult men.MethodsThis experimental crossover study assessed 15 subjects (30.38 ± 2.06 years; 88.40 ± 6.50 kg; 1.74 ± 0.07 cm) experienced in ST, evaluated under TMS, RP, and SST during flat bench press and leg press 45° exercises. Body composition, muscular strength via 1-RM testing, lactate concentration (LAC), and psycho-affective measures (Rating of Perceived Exertion-RPE; Visual Analog Scale-VAS; Feeling Scale-FS) were determined. Statistical analysis was performed using the Minitab software, with p ≤ 0.05, IC-95%).ResultsThe finals results showed SST exhibited a 38.10% lower LAC concentration post-training session compared to TMS, while RP showed 37.20% lower LAC concentration than TMS post-session. Average RPE values for RP and SST were higher (8.50 ± 1.10 and 8.60 ± 0.90, respectively) than TMS (6.00 ± 1.10). VAS displayed higher average values for RP and SST (8.00 ± 2.00 and 8.00 ± 1.00, respectively) compared to TMS (5.00 ± 1.00), with affective ratings indicating positive values for TMS and values between 0 and −5 for RP (40%) and SST (60%) post-training sessions, suggesting that RP and SST induced less affective response than TMS.DiscussionThe results lead to the conclusion that manipulation of training volume and intensity led to higher RPE and pain (VAS). The data suggest that inappropriate prescription of these systems could lead to greater displeasure, leading us to hypothesize that a higher likelihood of discontinuation from strength training programs would occur, suggesting that greater repetition volumes (RP and SST) should be targeted at individuals with a higher training level.
Percutaneous hollow nail internal fixation treatment for fractures of the pubic symphysis and its adjacent areas
Authors: Ping Zhang 
Published: October 2024

PurposeTo explore the percutaneous minimally invasive treatment of pubic symphysis and its adjacent fractures.MethodSince May 2021, 13 cases of fractures involving the pubic symphysis and its adjacent parts were treated with x-ray fluoroscopic localization and percutaneous cannulated screw fixation across the symphysis pubis, the guide pin pierced the symphysis pubis and the fracture end and stopped at the inner edge of the acetabulum. Visual analogue scale (VAS) was used to evaluate the effect of the operation, and the patients were followed up.ResultThe screw insertion operation time was 25–40 min, with an average of 31.45 min; The number of perspectives is 20–40, with an average of 28.75. The average intraoperative blood loss was 10 ml, and there were no puncture complications such as nerve or vascular damage. The initial stability of the fractured end of the patient after surgery was good. The VAS score decreased from preoperative 8–10 points to postoperative 1–2 points (average of 1.5 points). The follow-up time was 3–25 months, with an average of 8.5 months. At the last follow-up, the excellent and good rate of pelvic function according to Majeed pelvic function scoring system was 100%. One patient had screws removed 1.5 years after surgery, while the remaining twelve patients did not have screws removed. All patients did not experience any discomfort symptoms caused by pubic symphysis fixation.ConclusionPercutaneous hollow nail internal fixation is an effective method for treating fractures of the pubic symphysis and its adjacent parts.
COMPARISON OF THE EFFECTIVENESS GEL AND HYDROGEL OF RENGGAK LEAF ON PERINEAL WOUND HEALING IN RATS
Authors: Firdaus Ulfa Nadia Nurul , Runjati Runjati , Supriyadi Supriyadi 
Published: October 2024

Luka perineum dapat disebabkan oleh persalinan secara spontan oleh alat atau tindakan (episiotomi) dan terjadi selama kelahiran berlangsung. Luka perineum terjadi pada hampir semua persalinan pervaginam yang dialami oleh ibu primipara dan tidak jarang juga terjadi pada multipara. Data Kementerian Kesehatan tahun 2021 menunjukkan bahwa 83% ibu melahirkan pervaginam mengalami ruptur perineum, dengan 63% disebabkan oleh episiotomi dan 38% disebabkan oleh robekan spontan. Luka perineum yang tidak tertangani denganntepat dan cepat dapat menyebabkan keterbatasan aktivitas fisik serta gangguan laktasi. Penanganan non-farmakologi menggunakan ekstrak daun renggak menjadi solusi alternatif untuk penyembuhan luka perineum. Tujuan penelitian ini untuk mengetahui perbandingan gel dan hydrogel daun renggak (amomum dealbatum roxb) terhadap penyembuhan luka perineum pada tikus dibandingkan kelompok kontrol perawatan bersih kering. Jenis penelitian ini yaitu True Experiment dengan Post-test with Control Group menggunakan simple random sampling dengan jumlah sampel 24 ekor tikus betina (Rattus Norvegicus) yang dibagi menjadi 3 kelompok yaitu kelompok gel, hydrogel dan kelompok perawatan bersih kering. Instrumen yang digunakan yaitu lembar observasi skor skala REEDA. Analisis dalam penelitian ini menggunakan uji friedman dan Kruskal wallis. Hasil penelitian menunjukkan bahwa gel dan hydrogel daun renggak lebih cepat dalam proses penyembuhan luka perineum sejak hari pertama dibandingkan kelompok kontrol perawatan bersih kering. Hasil analisis kelompok intervensi dan kontrol terdapat penurunan skala REEDA yang bermakna dari hari ke 1 sampai hari ke 7, hal ini ditunjukkan dengan p-value sebesar 0,00 (p-value <0,05). Dapat disimpulkan bahwa pemberian gel dan hydrogel daun renggak efektif sebagai alternatif penyembuhan luka perineum
PAIN MANAGEMENT CARE IN DRY SOCKETS CASE AFTER MAXILARRY RIGHT SECOND INCICSOR EXTRACTION
Authors: Fatimah Irma Siti , Laela Dewi Sodja , Nurnaningsih Hera , Ningrum Nining 
Published: October 2024

Nyeri yang timbul akibat dry socket sangat mengganggu aktivitas sehari-hari klien. Rasa nyeri ini dapat berlangsung selama beberapa hari hingga minggu, dan dapat semakin parah saat makan atau minum. Asuhan manajemen nyeri pada kasus dry socket merupakan hal yang penting untuk dilakukan. Manajemen nyeri dapat mengurangi rasa nyeri dan ketidaknyamanan, sehingga klien dapat kembali beraktivitas secara normal. Studi kasus ini bertujuan mengetahui penurunan rasa nyeri pada klien penderita dry socket paska pencabutan gigi 22. Metode yang digunakan adalah laporan kasus dengan pendekatan konsep asuhan kesehatan gigi dan mulut yang terdiri dari proses pengkajian, diagnosis, perencanaan, implementasi dan evaluasi. Subjek pada studi kasus ini adalah Tn AP dengan keluhan satu minggu paska pencabutan gigi 22 daerah luka sekitar gusi terasa nyeri yang hebat. Subjek studi diberikan intervensi berupa asuhan manajemen nyeri. Pengukuran rasa nyeri menggunakan Numeric Rating Scale (NRS). Hasil pengkajian awal menunjukkan klien mengalami dry socket disertai nyeri skala 6. Asuhan manajemen nyeri yang diberikan pada klien memperlihatkan penurunan nyeri secara bertahap menjadi skala 0 pada minggu ke-2 . Klien memilih teknik distraksi, teknik fisiologis atau pijatan, terapi musik dan terapi termal panas yang dianggap nyaman dan efektif untuk mengatasi nyeri. Hasil evaluasi yang didapatkan yaitu terpenuhinya kebutuhan akan bebas dari rasa nyeri pada leher dan kepala, klien dapat mengimplementasikan teknik-teknik manajemen nyeri non-farmokologi. Intervensi asuhan manajemen nyeri dapat dijadikan alternatif penanggulangan kasus dry socket paska pencabutan gigi.
INCREASED PAROXONASE-3 LEVELS IN RATS FED HIGH CHOLESTEROL FEED WITH INDUCTION OF ETHANOL EXTRACT FROM KENIKIR LEAVES (COSMOS CAUDATUS)
Authors: Sarihati I Gusti Agung Dewi , Dhyanaputri I Gusti Ayu Sri , Bekti Heri Setiyo 
Published: October 2024

Ekspresi paraoxonase-3 (PON-3) pada HDL berhubungan dengan fungsi antioksidan HDL. PON3 merupakan protein yang penting dalam melindungi pembuluh darah dari aterosklerosis. Cosmos caudatus merupakan salah satu bahan alami yang berkhasiat meningkatkan kadar HDL. Tujuan penelitian adalah untuk menunjukkan pengaruh ekstrak etanol dari daun kenikir (C.caudatus) terhadap kadar PON-3 serum pada tikus yang diberi diet tinggi kolesterol. Penelitian dilakukan di Laboratorium Bio Mice and Rat dan Laboratorium Imunologi Poltekkes Kemenkes Denpasar. Penelitian ini menggunakan metode eksperimen sejati dengan Post-test Only Control Group Design. Sebanyak 24 ekor tikus jantan sebagai sampel dibagi menjadi 4 kelompok. Kelompok I (DS): tikus diberi pakan standar; kelompok 2 (DTK): tikus yang diberi diet tinggi kolesterol; kelompok 3 (Ss): tikus diberi pakan standar, diet tinggi kolesterol dan simvastatin 0,8 mg/kgBB, kelompok 4 (Cc): tikus diberi diet tinggi kolesterol dan ekstrak etanol daun kenikir 200mg/kg BB. Perlakuan diet tinggi kolesterol diberikan kepada kelompok DTK, Ss dan Cc selama 20 minggu. Pada minggu ke 17 hingga minggu ke 20, pada kelompok Ss diberikan tambahan simvastatin, kelompok Cc diberikan ekstrak etanol daun kenikir (C.caudatus), kelompok DS hanya diberikan pakan standar selama 20 minggu. Kadar serum PON3 diperiksa setelah 20 minggu perlakuan. Hasil menunjukkan kadar PON-3 serum tikus kelompok Cc lebih tinggi dibandingkan kelompok DTK. Uji one way anova menunjukkan bahwa ada perbedaan yang signifikan dengan p=0,006 dan kadarnya hampir sama dengan kelompok DS (p=0,891), namun lebih rendah dibandingkan Ss. Dari hasil tersebut disimpulkan bahwa terdapat pengaruh dari pemberian ekstrak etanol daun kenikir terhadap kadar PON-3 serum pada tikus.