bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glucocorticoid management of adrenal insufficiency in the United Kingdom: assessment using real-world data
Authors: Iqbal Kamran , Halsby Kate , Murray Robert D , Carroll Paul V , Petermann Robert 
Published: December 2018

Background and objectives
Glucocorticoids are used to manage adrenal insufficiency (AI). We describe treatments used in the United Kingdom and real-world clinical outcomes for each treatment.

Methods
We used 2010–2016 primary care data from The Health Improvement Network (THIN). Descriptive analyses were conducted, and differences in variables between patients prescribed immediate-release hydrocortisone (IR HC), prednisolone or modified-release hydrocortisone (MR HC) were assessed using Fisher’s exact test.

Results
Overall, 2648 patients were included: 1912 on IR HC (72%), 691 on prednisolone (26%) and 45 (2%) on MR HC. A total of 1174 (44.3%) had primary and 1150 (43.4%) had secondary AI. Patients on prednisolone were older (P < 0.001) and had a greater history of smoking (292/691, P < 0.001) and CVD (275/691, P < 0.001). Patients on MR HC had more PCOS (3/45, P = 0.001) and diabetes (27/45, P = 0.004). The number of GP visits/patient/year was 6.50 in IR HC, 9.54 in prednisolone and 9.11 in MR HC cohorts. The mean number of A&E visits and inpatient and outpatient hospital admissions ranged from 0.42 to 0.93 visits/patient/year. The mean number of adrenal crises/patient/year was between 0.02 and 0.03 for all cohorts.

Conclusion
IR HC is most commonly used for the management of AI in the United Kingdom, followed by prednisolone. Few patients receive MR HC. The prednisolone and MR HC cohorts displayed a greater prevalence of vascular risk factors compared with IR HC. The occurrence of AC and primary and secondary resource use were similar between treatment cohorts, and they indicate significant resource utilisation. Improved treatment and management of patients with AI is needed.
Reabilitação do guia canino complementar ao tratamento harmônico e estético com prótese parcial fixa livre de metal
Authors: Barros Vinicius Coronado , Barros Igor Coronado , Neto Joaquim Mesquita 
Published: December 2018

Os materiais mais resistentes falham pela falta de translucidez. Os mais estéticos, por sua vez, sofrem maior risco de fratura. Por isso, próteses metalocerâmicas e as livres de metal continuam dividindo as preferências e as indicações dos cirurgiões dentistas. As cerâmicas, com as melhores propriedades mecânicas, In-Ceram alumínio e In-Ceram zircônia. Estes sistemas tem alta resistência e oferecem uma ampla possibilidade de indicações e aplicação clinica, por exemplo, em próteses fixas unitárias, infraestrutura para pontes fixas e coroas sobre implantes, além de não apresentarem correntes galvânicas, o que contribui para a manutenção da saúde periodontal e pulpar, diminuição de acúmulo de placa, excelência estética, pela translucidez, opacidade, opalescência e fluorescência, além de serem superiores em relação às metalocerâmicas nos quesitos: corrosão, e biocompatibilidade. Então para o paciente ser considerado apto a receber restaurações protéticas livres de metal, deve possuir oclusão adequada e ausência de hábitos parafuncionais, para que estas não se fraturem em movimentos excêntricos e bordejantes durante as excursões mandibulares. O objetivo desse caso clínico que se optou pela reabilitação estética dos dentes anteriores com próteses livres de metal em cerâmica devido a excelência estética proporcionada pela mesma e principalmente pela ausência da margem metálica.PALAVRAS-CHAVE: Reabilitação oral, metal free, estética dentária.
Fragmentación y expansión demográfica en las poblaciones mexicanas de Pinus ayacahuite var. ayacahuite
Authors: Ortíz-Medrano Alejandra , Moreno-Letelier Alejandra , Piñero Daniel 
Published: December 2018

Se determinó la estructura filogeográfica y demografía histórica de las poblaciones mexicanas de Pinus ayacahuite var. ayacahuite usando tres microsatélites de cloroplasto en 198 individuos de 14 poblaciones. Se encontraron 12 haplotipos y niveles medios de diversidad genética (He= 0.705). Se definieron dos grupos máximamente diferenciados con un análisis espacial de varianza molecular. Entre estos grupos se detecta correlación significativa entre las distancias genéticas y las geográficas, pero no dentro de ellos. Se encontró estructura filogeográfica significativa en la muestra producida por la existencia de los dos grupos. Además, se detectaron dos expansiones demográficas, la primera en toda la especie, y la segunda sólo en las poblaciones más sureñas. Finalmente se realizó un análisis de ciados anidados para complementar nuestras observaciones. Los resultados muestran que el Istmo de Tehuantepec actuó como corredor para las especies de afinidades templadas en algún periodo frío de inicios del Pleistoceno, y posteriormente como una barrera.
Effects of Platelet-Rich Plasma (PRP) on Wound Healing in Nasal Mucosa
Authors: SARATAŞ Bilal , TÜZ Mustafa , SİVRİCE Mehmet Emre , YASAN Hasan , BOZKURT Kemal Kürşat 
Published: December 2018

AbstractObjective: Study
the effects of platelet-rich plasma (PRP) on wound healing
in nasal mucosa.Materials and
Methods: Thirty two adult New Zealand white rabbit of
male sex were used for this study each weighing between 2800 and 3500
grams.Mucosal damage was created by interdental brush (brushing technique). The
animals were randomly distributed into two groups as first week group and third
week group. This two groups were subdivided into two subgroups as control and
PRP.Results:
According to the histopathologic scoring results, in first week group
statistically significant difference was observed in term of inflammation
severity between PRP and control subgroups (p =0.009). No
statistically significant difference was observed between the other groups in
terms of mucosal edema severity, loss of cilia degree between ciliary
cells,fibrosis severity, goblet cell hyperplasia, inflammation severity, congestion
and squamous metaplasia.

Conclusion: Our results show that PRP reduces inflammation in early stages of
wound healing. We believe further more studies are needed to understand the effects
of PRP on nasal mucosal wound healing.
Judicial Review of Mining Exploration-Exploitation Licenses-Permits and Revocations in Forest Areas
Authors: CESUR İlknur , GÜLOĞLU Yavuz 
Published: December 2018

Aim of study:
The aim of this study is to identify issues pertaining to the justifications of
the annulment decisions of the administrative judiciary in the cases of actions
for annulment brought against the revocations of mining licenses and permits
for mining activities granted by the administration due to reasons specified by
the legislation.

Area of study:
This study addresses licenses and permits granted for mining activities in
Turkey and judicial review of the revocations of these licenses and permits.

Material and Method:
The main material of the study is the current legislation on mining activities
and the judicial decisions for the cancellation of mining licenses / permits.
The method of study is to evaluate the materials together and to determine the
reasons for the cancellation and rejection decisions of the judiciary.

Main results:
Sanctions in the Mining Law should take into account future generations, stop
improper practices and ensure that mining activities are compatible with the
environment and human rights.

Research highlights:
Revocation of mining exploration-exploitation licenses in forest areas is an
issue that warrants further research and careful evaluation. Judicial decisions
play key role in filling the legal gaps in mining exploration and exploitation.
Journal of the IEST Marks 60th Anniversary
Authors: Burrows Roberta 
Published: December 2018

Archive provides insight into 60 years of scientific advancement
During the past six decades, thousands of authors and reviewers have contributed to technical innovation through IEST's flagship scientific publication, known today as the Journal of the IEST. Established in 1958 as the Journal of Environmental Engineering, primarily to report on environmental testing research, today's Journal of the IEST covers a broad range of topics: contamination control, reliability assessment and evaluation, nanotechnology facility design, laboratory and field-testing and evaluation, and environmental instrumentation and effects. As the official publication of the IEST, the Journal serves as a permanent record of progress in the environmental sciences and is archived in the United States Library of Congress.
Complex Coherence Constraint for the Definition of the Spectral Density Matrix
Authors: Liu Zhihua , Cai Chenguang , Xia Yan , Yang Ming 
Published: December 2018

Abstract
The cross spectral density (CSD) for a multiple-input/multiple-output (MIMO) random vibration is typically defined by the complex coherence consisting of the modulus and the phase. The purpose of this paper is to present a constraint for the complex coherence to allow the CSD to be defined more easily. The study of the complex coherence constraint is based on Cholesky decomposition of the spectral density matrix (SDM). The complex coherence must be bounded in the interior or on the boundary of a constraint circle to ensure a physically realizable random vibration. This paper proposes a new approach to define the complex coherences of the SDM by using recursive formulas based on the constraint circle.
Contribución de la robótica educativa en la adquisición de conocimientos de matemáticas en la Educación Primaria/ Contribution of educational robotics in the acquisition of mathematical knowledge in primary education
Authors: Suárez Zapata Adrián , García Costa Daniel , Martínez Delgado Pedro A. , Martos Torres Julio 
Published: December 2018

Este trabajo tiene por objetivo utilizar una plataforma robótica educativa como herramienta de refuerzo en la adquisición de las competencias relacionadas con el pensamiento computacional y matemático en alumnos de Educación Primaria. Se entiende el pensamiento computacional como un conjunto de habilidades, entre las que se incluye el pensamiento algorítmico, mediante las que cualquier persona es capaz de resolver problemas. Los contenidos a desarrollar se abordarán empleando la estrategia pedagógica STEM, combinando las disciplinas de Ciencia, Tecnología, Ingeniería y Matemáticas en el proceso de aprendizaje. En este sentido, se propone la adaptación del entorno tecnológico para poder emplearlo en edades tempranas. Concretamente, se proponen varios enunciados relacionados con la resolución de problemas matemáticos enmarcados en el nivel de Educación Primaria y se va a realizar una adaptación de los bloques de programación necesarios para solucionarlos. Para ello, se crean diferentes bloques personalizados de programación, en los que el docente puede incluir comportamientos más complejos que serán transparentes para el alumno. Por consiguiente, el alumno podrá resolver un abanico mayor de problemas, liminando la posibilidad de que el entorno de programación ofrezca limitaciones que se traduzcan en un aumento de la complejidad.
The Analysis of Amil Zakat Institution/Lembaga Amil Zakat (LAZ) Accountability toward Public Satisfaction and Trust
Authors: Ahmad Zulfikar Ali , Rusdianto Rusdianto 
Published: December 2018

Abstract Indonesia has a high potency of zakat fund but the result of its collection shows the great gap compared with the potency. The current issue of Amil Zakat Institution/Lembaga Amil Zakat (LAZ) is about their public trust and public satisfaction. The aim of the research is to examine an impact of LAZ’s accountability on public satisfaction and public trust among muzakki in Indonesia. This research collects data using questionnaire from muzakki who paid their zakat in LAZ’s. This study uses SEM-PLS to analyze data. The result shows (1) significant influence on the LAZ’s accountability to public satisfaction, (2) public satisfaction on LAZ has a significant influence to public trust.Abstrak Indonesia memiliki potensi dana zakat yang tinggi, namun hasil dari pengumpulannya menunjukkan ada perbedaan yang besar dibandingkan dengan potensinya. Permasalahan yang dihadapi oleh lembaga amil zakat (LAZ) sekarang adalah terkait dengan kepercayaan publik dan kepuasan publik. Tujuan penelitian ini adalah menguji pengaruh akuntabilitas LAZ terhadap kepuasan publik dan kepercayaan publik. Penelitian ini mengumpulkan data menggunakan kuisioner dari muzakki yang membayar zakat di LAZ. Penelitian ini menganalisa data yang terkumpul menggunakan SEM-PLS. Hasil penelitian menunjukkan (1) adanya pengaruh yang signifikan dari akuntabilitas lembaga amil zakat terhadap kepuasan publik, (2) kepuasan publik atas lembaga amil zakat mempunyai pengaruh signifikan atas kepercayaan publik.
Impacts and Reflections on the Making Meaning Symposium for Small, Independent Libraries
Authors: Leonhardt Eric 
Published: December 2018

Abstract
This paper discusses how a small volunteer library changed after attending a symposium on Indigenous Librarianship and metadata. It provides an introduction to the Aboriginal Teacher Education Program Library, how it was formed, and the decision making process behind it. The paper goes on to summarize key points from speakers at the Making Meaning Symposium, and how they challenge the choices made by volunteers. The results have all been positive, and continue to shape discussions about how to best implement what was learned.
When we think we know, we think we own something, and we take away from what it represents.
-Ambrose Cardinal, personal communication
Aplicação de Filtro de Partículas para Estimação do Comportamento de Válvulas em Condição de Falha
Authors: Demuner Larissa Rodrigues , Rangel Fernanda Dassie , Dutra Julio Cesar Sampaio , Da Silva Wellington Betencurte 
Published: December 2018

O monitoramento e o controle de processos químicos realizados de modo satisfatório são primordiais para o atendimento dos objetivos operacionais. Estes processos são dinâmicos e apresentam elementos não gaussianos e não lineares, que tornam necessárias ferramentas para auxiliar em uma análise mais precisa. Na Engenharia Química, é comum o uso de tanques para armazenar misturas e produtos e reduzir perturbações. A esses tanques, estão associadas válvulas que regulam o nível do material acumulado para manter a quantidade desejada e garantir a segurança na planta. Diante da dificuldade em detectar falhas nessas válvulas, a estimação de parâmetros utilizando filtros de partículas é uma solução viável para este problema. Neste trabalho, estimou-se o coeficiente de uma válvula e recuperaram-se as medidas de nível, utilizando-se o Filtro SIR. Foram obtidos resultados satisfatórios ao se variar o número de partículas, o nível de incerteza do modelo e o tipo de informação a priori.DOI: 2446941601012015073
Tratamento de soluções aquosas de íons cálcio usando casca de arroz em batelada e em leito empacotado
Authors: De Gasper Jeferson , Pitol-Filho Luizildo 
Published: December 2018

Um dos grandes responsáveis pela poluição das águas e dos solos são os efluentes industriais. Devido ao alto custo de tratamento, os efluentes contendo contaminantes, como metais, são depositados diretamente nos rios ou no próprio solo. Dentre os métodos utilizados para o tratamento desses efluentes, a adsorção vem ganhando destaque por ser um método eficiente, de fácil aplicação e de custo relativamente baixo quando se utilizam materiais alternativos. O presente trabalho estuda a aplicação da casca e da cinza da casca de arroz como adsorventes na remoção de cálcio de soluções aquosas. Os ensaios foram realizados em batelada e em leito empacotado de comprimento de 200 mm, variando o diâmetro em 20 e 32 mm. Nos ensaios em batelada obteve-se, com a cinza da casca de arroz, a capacidade máxima de adsorção de 0,142 mmol g-1. Nos ensaios em coluna os resultados da cinza da casca de arroz também foram superiores, com destaque para a coluna de diâmetro de 32 mm, que indicou através dos resultados de pH maior capacidade de adsorção de cálcio. Deste modo, conclui-se que a adsorção pode ser uma destinação sustentável dos subprodutos do beneficiamento do arroz.doi: https://doi.org/10.18540/2446941602012016029
JCEC/REQ2: THE LAUNCHING OF ISSUE V. 2, N. 1 (2016)/ O PERIÓDICO JCEC/REQ2: LANÇAMENTO DA EDIÇÃO V. 2, N. 1 (2016)
Authors: Siqueira Antonio Marcos de Oliveira 
Published: December 2018

In this issue, v. 2, n. 1 (2016), the journal presents 4 (four) articles to the scientific community in 3 (three) thematic areas: 1) Simulation, Optimization and Process Control/Simulação, Otimização e Controle de Processos: Modelo para estimativa de perdas de reagentes em processo de produção de dióxido de cloro; 2) Engineering of Separations and Thermodynamics/Engenharia das Separações e Termodinâmica: Predição da pressão de vapor e do calor de vaporização de compostos relacionados à produção de biocombustíveis; and, Tratamento de soluções aquosas de íons cálcio usando casca de arroz em batelada e em leito empacotado; 4) Chemistry and Chemical Engineering Education/Ensino de Química e Engenharia Química: Compreensão sobre a epistemologia da ciência apresentada por estudantes da Pós-Graduação em Agroquímica da UFV.The JCEC/REQ2 editorial board wishes all readers can enjoy the subject published in this issue.doi: https://doi.org/10.18540/2446941602012016057
Selected polymorphisms of VEGF gene in chronic renal failure
Authors: Żywiec Joanna , Kiliś-Pstrusińska Katarzyna , Grzeszczak Władysław 
Published: December 2018

WstępPoznanie złożonej etiopatogenezy przewlekłej choroby nerek (PChN) budzi nadzieje na rozwój skutecznych metod jej wczesnej diagnostyki oraz skutecznej profilaktyki i leczenia. Liczne badania dowodzą znaczenia predyspozycji genetycznej w rozwoju przewlekłego uszkodzenia nerek w przebiegu różnych chorób.
Celem pracy była ocena związku wybranych polimorfizmów genu VEGF (<i>vascular endothelial growth factor</i>) z występowaniem przewlekłej choroby nerek.Materiał i metodyGrupę badaną stanowiły 103 rodziny (<i>trios</i>): dwoje biologicznych rodziców i dziecko z PChN w stadium co najmniej trzecim, tj. z eGFR ≤ 60 ml/min/1,73 m2, na tle przewlekłego kłębuszkowego zapalenia nerek (29%) lub nefropatii śródmiąższowej (71%). W chwili badania średni wiek dzieci z PChN wynosił 15,2 roku, a średnia filtracja kłębuszkowa 28,9 ml/min/1,73 m2. U 45% chorych zastosowano leczenie zachowawcze, u pozostałych nerkozastępcze. U wszystkich badanych pobrano jednorazowo próbki krwi żylnej w celu wyizolowania materiału genetycznego i przeprowadzono genotypowanie wybranych polimorfizmów genu VEGF metodą TaqMan. Do opracowania statystycznego wyników posłużyły programy Statistica 10 i Microsoft Office Excel 2003 z wykorzystaniem testu nierównowagi sprzężeń (<i>transmission disequilibrium test</i> – TDT), testu χ2 oraz estymatora Kaplana-Meiera. Za granicę istotności statystycznej przyjęto wartości p < 0,05.WynikiNie wykazano różnic w przekazywaniu alleli badanych polimorfizmów rs699947 i rs1570360 genu VEGF od rodziców do potomka z PChN.WnioskiNie stwierdzono związku polimorfizmów rs699947 i rs1570360 genu VEGF z występowaniem przewlekłej choroby nerek w stadium ≥ 3.
Penggunaan Imunostik sebagai Uji Serologi untuk Deteksi Brucella abortus pada Sapi (APPLICATION IMMUNOSTICK ASSAY FOR SEROLOGICAL TEST BRUCELLA ABORTUS IN BOVINE)
Authors: Astarina Dhevie Kenny , Pribadi Eko Sugeng , Pasaribu Fachriyan Hasmi 
Published: December 2018

Serological test is one of diagnostic method to detect pathogenicity brucella. Several methods are being improving such as Rose Bengal Test (RBT), Complement Fixation Test (CFT) dan Enzyme-linked Immunosorbent Assay (ELISA). Immunostick has an accuracy equivalent to ELISA and is easy to apply in the field so it is possible to be applied as a rapid test for brucellosis detection. The study aim was to know sensitivity and specificity of immunostick that were used to detecte antibody Brucella abortus using commercial antigens of B. abortus Strain 19 (S19) and B. abortus Strain 99 (S99). The test have compared with ELISA. The tests were conducted in two stages, namely (i) immunostick ability to detect antibodies in seropositive and seronegative serum, and (ii) the immunostick result were compared with ELISA result in serum grup that were be know and unknown status. A total of 250 serums were examined and result indicated that immunostick can be detect B. abortus antibodies in cattle serum with sensitivity 100%. Immunostick specifity were 45,45% for B. abortus S99(1) antigen; 78,79% for B. abortus S99(2) antigen and 51,52% for B. abortus S19 antigen. When the test compared with ELISA, the sensitivity 82,86% and the spesifity were 52,31% for B. abortus S99(1) antigen; 93,54% and 79,71 for B. abortus S99(2) antigen and 82,86% and 58,46% for B. abortus S19 antigen.
Eve's Ekg and Echocardiogram by W.J. Hall
Authors: Crichton Madeline C. 
Published: December 2018

Hall, Wendy J. Eve's Ekg and Echocardiogram. Mediwonderland, 2018.
Another installment in her Mediwonderland series of children’s books intended to provide accessible and comprehensible knowledge of medical afflictions and tests, Wendy J. Hall’s Eve’s EKG and Echocardiogram focuses on the world of cardiovascular health-related tests. Beginning the story with the protagonist, Eve, suffering chest pains, readers see Eve being rushed to the hospital and undergoing several tests. Ending with the doctor’s prognosis that Eve’s chest pains are likely caused by overuse, the reader is left better informed and comforted. Although Eve was initially scared to do the tests, she is comforted by the doctor’s excellent bedside manner, and inevitably enjoys the process and the exciting experiences such as getting to see her heart beating in an echocardiogram.
Written mostly as a dialogue between Eve, her mom, and the various doctors and nurses, the text flows believably and is very easy to read. Hall uses emotion to engage with the reader. The font is large, clear, and well-spaced so that many young readers will be able to read it independently, or with moderate assistance. Although the medical terminology included is complex, all the tests mentioned are explained simply enough for a child to understand. Colour images accompany each page of text, and represent an overview of what happens on each page of the story to increase comprehension. Overall, Hall’s Eve’s EKG and Echocardiogram is an entertaining, educational must read!
Highly Recommended: 4 out of 4 starsReviewer: Madeline C. Crichton
Madeline Crichton is a University of Alberta undergraduate student with a lifelong passion for reading. When she is not preoccupied with her studies, Madeline is busy volunteering in a variety of roles in her community.