bluuebunny/crossref_metadata_2025_split huggingface dataset:
ONS-5010 (bevacizumab-vikg) Safety and Efficacy in Subfoveal Choroidal Neovascularization Secondary to Age-related Macular Degeneration
Authors: Rahhal Firas M. , Hu Allen , Humayun Mark , George Meena S. , Javid Cameron , Brown Jeremiah , Pitcher John D. , Dagnon Terry , Kissner Jennifer 
Published: November 2024

Background and Objective
This was a prospective multicenter, randomized, double-masked, active-controlled study, the aim of which was to demonstrate the efficacy and safety of intravitreal ONS-5010 (bevacizumab-vikg) in eyes with neovascular age-related macular degeneration (nAMD). This was a phase III trial on ONS-5010 (NORSE TWO).

Materials and Methods
Treatment-naïve nAMD patients aged 50 years and older with a best-corrected distance visual acuity (BCVA) of 25 to 67 Early Treatment Diabetic Retinopathy Study (ETDRS) letters and evidence of disease activity were included. Subjects randomized to ONS-5010 received monthly intravitreal doses of 1.25 mg of ONS-5010, bevacizumab-vikg (Outlook Therapeutics) for 12 months. Subjects randomized to ranibizumab received 0.50 mg of ranibizumab on days 0, 30, 60, 150, and 240 based on the PIER study dosing regimen.

Results

The primary end point was the proportion of subjects who gained ≥ 15 letters from baseline in BCVA at 11 months, and evaluating the safety and tolerability of intravitreal injections of ONS-5010 administered monthly from baseline to 12 months. One hundred thirteen subjects were included in the ONS-5010 group and 115 subjects were included in the ranibizumab group. Respectively, 41.7% and 23.1% of patients gained ≥ 15 letters (3 lines) of visual acuity, with a risk difference of 0.1859 [95% CI = 0.0442, 0.3086];
P
= 0.0052. The change in BCVA from baseline to 11 months was found to be 11.2 ± 12.19 and 5.8 ± 14.80 ETDRS letters, respectively. The number of subjects gaining ≥ 5 and ≥ 10 letters and subjects losing < 15 letters was significantly higher in the ONS-5010 group. Similarly, subjects with a Snellen visual acuity equivalent of 20/200 (35 ETDRS letters) or worse at 11 months were significantly fewer in the ONS-5010 group. Only one subject in the ONS-5010 group had a study-related serious ocular adverse event (SAE), namely, elevated intraocular pressure. The most common adverse event in the ONS-5010 group was conjunctival hemorrhage (8.8%), and reduced visual acuity in the ranibizumab group (12.2%).

Conclusions
In the prescribed treatment plan, ONS-5010 exhibited strong effectiveness in improving or stabilizing visual acuity and was also well tolerated. Bevacizumab and ranibizumab displayed a comparable safety profile.

[
Ophthalmic Surg Lasers Imaging Retina
2024;55:XX–XX.]
Subthreshold Micropulse Laser for Eyes: With Center Involving Diabetic Macular Edema With Good Visual Acuity: The PULSE Study, a Randomized Clinical Trial
Authors: Feldman Samuel , Basra Jesse , Lawani Anjola , Ren Yunyi , Wilson Machelle , Moshiri Ala , Park Susanna S. , Yiu Glenn 
Published: November 2024

Background and Objective
To determine if subthreshold micropulse laser (SML) therapy can prevent or delay vision loss in diabetic macular edema (DME) with good visual acuity (VA).

Patients and Methods
Prospective, single-masked, sham-controlled trial in 27 eyes of 19 adult patients with treatment-naïve, center-involved DME, and VA of 20/25 or better. Measures included best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), contrast sensitivity (CS), average threshold on microperimetry, and central subfield thickness (CST). The primary outcome measure was median time to vision loss of 10 letters at any visit or 5 to 9 letters at two consecutive visits ≤ 28 days apart.

Results

Eight eyes met vision loss criteria during the 2-year study, with similar proportions for SML (
n
= 5) and sham (
n
= 3). Median time to vision loss was 5 months for both groups. At 6 months, there were no statistical differences in BCVA, LLVA, CS, microperimetry threshold, and CST between SML and sham arms (
P
> 0.05 in all measures).

Conclusion
In eyes with center-involved DME and good VA, SML did not prevent or delay the vision loss threshold for initiating anti-VEGF therapy. However, these results may be affected by a high rate of early participant dropout from the study.

[
Ophthalmic Surg Lasers Imaging Retina
2025;56:86–93.]
L’État sans frontières
Authors: Lacroix Thomas 
Published: November 2024

Accords de double nationalité, externalisation des contrôles aux frontières, multiplication des ministères publics en charge des diasporas… Les États développent un nombre croissant d’instruments pour intervenir au-delà de leurs frontières. Comment les politiques ciblant les flux migratoires transforment-elles l’État ? Le présent ouvrage renouvelle un débat sur le transnationalisme qui, depuis plus de trente ans, anime les études migratoires. Thomas Lacroix explore la relation étroite entre « État transnational », c’est-à-dire l’ensemble des politiques et administrations d’un État destinées à réguler les flux transnationaux, et « société transnationale », soit l’écheveau des institutions sociales permettant de maintenir des liens, des pratiques et des relations par-delà les frontières. L’auteur propose ainsi la première théorie globale de l’État transnational en lien avec une théorie sociale de la société transnationale. S’appuyant sur plus de vingt ans de recherches sur des terrains variés – dans les pays du Nord comme du Sud, dans des espaces de départ, de transit ou de destination –, ce livre fournit aux spécialistes et étudiants une boîte à outils conceptuelle permettant d’appréhender aussi bien les pratiques des migrants que les politiques d’État.
La Chine en scène
Authors: Soulier Eliette 
Published: November 2024

La circulation des savoirs n’est pas seulement l’affaire des savants et des ouvrages scientifiques. La littérature de fiction a également joué un rôle important dans la dissémination des savoirs sur la Chine en Europe. En Espagne, à l’époque moderne, le théâtre a permis de rendre accessibles des informations, plus ou moins exactes, à un public moins lettré que les seuls destinataires de l’écrit. Dans cet article, nous nous proposons d’étudier le rôle joué par les comedias du xviie siècle et les tragédies néo-classiques du xviiie dans la circulation des savoirs sur la Chine au sein de la société espagnole. Nous montrerons qu’au cours de ces deux siècles, les représentations théâtrales mirent en scène une Chine de mots et de décors de plus en plus ressemblante à l’originale. Néanmoins, la persistance d’erreurs factuelles et d’amalgames avec d’autres peuples non européens révèle une méconnaissance durable de l’empire du Milieu ainsi que les divers enjeux littéraires et idéologiques qui présidèrent à la composition de ces œuvres.
La circulation des connaissances sur la Mandchourie (1840-1900)
Authors: Maréchal Anne Dalles 
Published: November 2024

Dans les écrits des missionnaires de Mandchourie, les informations se croisent et donnent une idée de la vie de ces hommes : aux soucis financiers, toujours au cœur du quotidien missionnaire, se mêlent les aléas de la vie en terre lointaine. Ces écrits circulent ensuite en Europe et donnent au lectorat des publications missionnaires une idée bien précise de la Mandchourie. Dans un premier temps, je propose de m’intéresser à ces sources ethnographiques de première main. Le travail de publication et d’édition permettra de s’intéresser ensuite aux enjeux de ces ouvrages et de s’interroger sur la circulation des savoirs sur la Mandchourie en Europe. Cet article s’appuie sur un travail sur les archives des Missions étrangères de Paris (AMEP) et sur les périodiques missionnaires chrétiens publiés au xixe siècle.
Oublis et résurgences : les techniques inscrites dans un fragment de ceinture de chef des îles de la Société (maro ʻura)
Authors: Alevêque Guillaume , Leclerc-Caffarel Stéphanie , Maric Tamara , Vallée Marine 
Published: November 2024

La découverte en 2016 d’un fragment textile unique au musée du quai Branly – Jacques Chirac (mqB-JC) offre des indices matériels inédits pour étudier les maro ‘ura, parmi les attributs les plus emblématiques du pouvoir des ariʻi rahi, les grands chefs des îles de la Société en Polynésie aujourd’hui française. En effet, aucun exemple ne semblait jusqu’ici avoir survécu à la conversion de l’archipel au christianisme au début du xixe siècle. Une étude pluridisciplinaire s’engage alors. En partie présentée lors d’une exposition inaugurée en octobre 2021 au mqB-JC, elle révèle un essaim d’histoires, de données techniques et d’hypothèses que cet article interroge à l’aune de mécanismes mnémoniques complexes, de phénomènes d’oubli et de résurgence. Suite au retour de ce fragment à Tahiti en 2022, l’article retrace la biographie ancienne de l’objet et examine ses fonctions de support de mémoire ainsi que les pratiques techniques qu’il illustre. Selon différentes temporalités, il souligne les enjeux de la création, de l’usage et de la préservation des objets sacrés polynésiens, du xviiie siècle à nos jours.
Costruire la storia, mattoncino su mattoncino. La “Public Brickstory”: i lego come strumento per raccontare la storia
Authors: Bartolini Stefano , Cutolo Francesco 
Published: November 2024

Nel contributo, dopo aver delineato come l’azienda LEGO ha rappresentato nei propri sets i temi storici e militari, esamineremo anzitutto il fenomeno socioculturale della “Lego History”, ovvero gli appassionati lego che si dedicano a soggetti e a costruzioni a tema storico. Secondariamente, discuteremo alcuni possibili impieghi dei lego – in quanto “media” con una forte presa sul pubblico – ai fini della Public History, trattandone le problematicità, le metodologie e gli obbiettivi, e presentando alcuni progetti avviati all’estero. Infine, illustreremo il nostro progetto, Italian BrickHistory, un sito web che si propone come punto di incontro tra i lego historical builders, gli appassionati, gli storici e gli operatori culturali impegnati nella Public History attraverso i lego.
Enhancing brewery logistics with smart kegs: A simulation study
Authors: Nettesheim Philipp M. , Burggräf Peter , Steinberg Fabian 
Published: November 2024

Background: Supply chain optimisation is critical for companies in today’s globalised world. Efficient supply chains ensure product quality and freshness in the food industry. For products like beer, efficiency extends beyond transportation and includes the management of logistics containers such as returnable kegs.Objectives: This study investigated the impact of tracking logistics data on the efficiency of container logistics in a small regional brewery. The focus was reducing fleet size, processing times and pick-up distances.Method: A simulation of a small brewery was used to analyse the impact of tracking logistics data. The study examined how kegs equipped with real-time tracking technology could improve logistics operations.Results: The simulation showed that tracking logistics data significantly improved logistics processes. It led to a reduction in the fleet size, turnaround times and pick-up distances for empty kegs. These improvements were attributed to better resource allocation and more efficient management of reusable containers.Conclusion: The study showed that smart kegs could reduce logistical inefficiencies in the brewing industry. The use of smart technologies in container logistics improves operational efficiency and sustainability.Contribution: This research provides insights into how smart technologies can transform traditional logistics models. The results suggest that smart containers can revolutionise supply chains with efficient resource allocation, real-time tracking and automation. This shift towards smart logistics aligns with the broader adoption of the Industrial Internet of Things, offering a blueprint for future innovations in supply chain management. The implications extend beyond brewing, highlighting the potential for greater sustainability and a positive reduction in environmental impact in global supply chains.
Surface Electromyography for the Diagnosis of Tremor Syndrome: A Study of 97 Patients
Authors: Gulati Kartika , Pandey Sanjay 
Published: November 2024

Abstract

Background and Objectives:
Tremor is one of the most frequent movement disorders encountered in clinical practice with heterogeneous phenomenology and etiology. Surface electromyography (SEMG) is a noninvasive and reproducible test that can diagnose tremor syndromes.

Methods:
In this retrospective study, the clinical and electrophysiologic records of 97 consecutive patients with tremor syndromes who visited our movement disorder clinic between January 2023 and March 2024 were examined.

Results:
In our study, 28.8% (n = 28) of patients were of essential tremor (ET) syndrome. SEMG of ET syndrome patients showed synchronous bursts in 71.4% (n = 20), alternating bursts in 10.7% (n = 3), synchronous bursts with co-contraction of agonist and antagonist muscles in 10.7% (n = 3), and both synchronous and alternating bursts in 3.6% (n = 1) of patients. Tremor–ataxia syndrome formed 21.6% (n = 21) of our study population, with 71.4% (n = 15) of patients showing synchronous bursts and co-contraction and 28.6% (n = 6) patients having alternating bursts. Moreover, 12.3% (n = 12) patients were of parkinsonian tremor, of whom alternating bursts were present in 75% (n = 9) and synchronous bursts with co-contraction were present in 25% (n = 3) of patients. In addition, 11.3% (n = 11) of patients had dystonic tremor (DT), of whom 81.8% (n = 9) had synchronous bursts and co-contraction and 18.2% (n = 2) had alternating bursts.

Conclusions:
Synchronous bursts with co-contraction suggestive of DT were observed in most patients with tremor–ataxia syndrome and a small number of patients with ET syndrome. Our data suggests that SEMG helps differentiate these two clinical syndromes, which is difficult in a clinical setting.
The Effect of Different Obturation Techniques on the Sealing Ability of Root Canal Filling Materials
Authors: Lakshmi Regula Sri , Das Bhaskar , Jadhav Apurva , Haridas Harsha , Murugesan Sabari , Subramani Savadamoorthi Kamatchi 
Published: November 2024

ABSTRACT

Background:
The performance of root canal filling materials in sealing is crucial for the effectiveness of endodontic procedures as it prevents the escape of microorganisms and guarantees the durability of the treatment.

Materials and Methods:
The present in vitro investigation included the preparation of 90 human single-rooted teeth using a standardized process. These teeth were then randomly separated into three groups (n = 30) according to the obturation technique: Group A (Lateral Compaction), Group B (Thermafil), and Group C (Continuous Wave of Condensation). Furthermore, each group was separated into two subgroups based on the specific kind of root canal filling material employed: Subgroup 1 (Gutta-Percha) and Subgroup 2 (Resilon). The sealing capacity was evaluated using a dye penetration technique, with measurements conducted at three specific time intervals: 24 hours, 1 week, and 4 weeks after the obturation process. Statistical analysis of the data was conducted using analysis of variance and post hoc tests to identify significant differences across groups.

Results:
The findings showed that the Continuous Wave of Condensation method (Group C) had the lowest dye penetration, with an average depth of penetration of 1.2 mm. The Thermafil technique (Group B) followed closely with a penetration depth of 1.8 mm, while the Lateral Compaction technique (Group A) achieved a penetration depth of 2.5 mm. In terms of sealing ability, Gutta-Percha demonstrated superior performance compared to Resilon, achieving average penetration depths of 1.5 mm and 2.0 mm, respectively. Statistical analysis showed statistically significant differences between the groups (P < 0.05), with the Continuous Wave of Condensation approach utilizing Gutta-Percha showing the highest level of sealing effectiveness.

Conclusion:
In conclusion, the Continuous Wave of Condensation approach showed a substantial improvement in the sealing efficacy of root canal fillings when compared to the Lateral Compaction and Thermafil procedures.
Antidiabetic Potential of Hylocereus Polyrhizus and Hylocereus Megalanthus Fruit Peel: An In vitro Study
Authors: Alhodieb Fahad Saad. 
Published: November 2024

ABSTRACT

Background:
Diabetes is a chronic metabolic condition affecting mainly carbohydrate metabolism. Dragon fruit is a commonly consumed fruit in Asia-pacific countries, with reported anti-diabetic potential.

Objectives:
The presents study explores the use of dragon fruit peel as an anti-diabetic supplement.

Materials And Method:
Fruit peels from two varieties (Red and Yellow) were evaluated for their ability to absorb glucose, inhibit glucose diffusion, and inhibit starch digestion using in vitro models.

Result:
Both red and yellow dragon fruit peel powder samples decreased starch digestion significantly compared to wheat bran and inhibited glucose diffusion, as indicated by the glucose dialysis retardation index (GDRI) values.

Conclusion:
The findings of the study indicate that both red and yellow dragon fruit peel possesses significant antidiabetic potential.
Comparison of Bacterial Adherence on Different Archwires after Clinical Use
Authors: Ashique Abdulhameed Syed , Mude Nakul N. , Chandrasekaran Divya , Goswami Dwijesh S. , Almutairi Omar Naif , Manimegalan Priya 
Published: November 2024

ABSTRACT

Background:
An essential component of orthodontic therapy, orthodontic archwires may operate as surfaces for bacterial adhesion, which might result in issues with oral health.

Materials and Methods:
This study assessed the bacterial adhesion to three different kinds of orthodontic archwires: beta-titanium (TMA), nickel-titanium (NiTi), and stainless steel (SS). At the conclusion of the clinical usage period, samples of each kind of archwire were gathered and submitted to microbiological investigation in order to determine the quantity of adhering bacterial colonies. Using scanning electron microscopy (SEM), the surface properties of the archwires were evaluated after usage.

Results:
The three kinds of archwires had significantly different rates of bacterial adhesion, according to the findings. With an average of 1500 ± 50 CFU/mm2, SS archwires showed the highest level of bacterial adhesion, followed by NiTi archwires at 1100 ± 45 CFU/mm2. The least amount of bacteria adhered to TMA archwires, with an average of 800 ± 30 CFU/mm2. According to SEM pictures, the degree of bacterial adhesion was associated with the archwires’ surface roughness, with smoother surfaces showing less bacterial colonization.

Conclusion:
In comparison with SS and NiTi archwires, the research finds that TMA archwires are linked to the least amount of bacterial adhesion.
Determination of the Mineral Content, Phytochemical Properties, and the Antimicrobial Properties of the Seed Extracts of Carica papaya on some Clinical Isolates
Authors: Udinyiwe Osayamen Collins , Omoregie Andrew Edosa 
Published: November 2024

Abstract
Medicinal plants are common in our environment and have been useful in traditional medicine. The present study was conducted to evaluate the mineral content, the phytochemical, and antimicrobial properties of Carica papaya seed extracts on clinical isolates. The C. papaya seeds were sourced from fruits sellers from the Ekosodin community in Ovia North East Local Government, Benin City, Edo State. The seeds were air-dried for 14 days. The extract was obtained by maceration using distilled water and ethanol as solvents. The results of the mineral composition for both aqueous and ethanolic extracts indicated that sodium, potassium, calcium, zinc, copper, phosphorus, nitrogen, chromium, and iron were present. The phytochemical screening for both aqueous and ethanolic extracts indicated the presence of compounds such as saponins, phenolics, alkaloids, and flavonoids. The antimicrobial assay revealed that C. papaya seed extracts had good antimicrobial properties with a minimum inhibition of 100 mg/mL observed in Staphylococcus epidermidis and Bacillus subtilis for the aqueous extract, 1.04 mg/ml S. epidermidis and B. subtilis, and 2.08 mg/ml Candida spp. for the ethanol extract. The minimum bactericidal concentration of the ethanol extract in this study was 4.16 mg/ml for S. epidermidis and 8.33 mg/ml for B. subtilis, and the minimum fungicidal concentration was 8.33 mg/ml for Candida spp. The results from this study indicated that C. papaya seeds possess sufficient mineral components and phytochemical components, indicating their potential use as supplementary antimicrobial agents and essential nutrients for both humans and animals.
Screening of Jellyfish Venom Inhibitors from Beach Morning Glory (Ipomoea pes-caprae) against Nemopilema nomurai
Authors: Vo Khanh-Hung , Nguyen Ngoc-Bao-Minh , Le Duy-Anh-Quan , Nguyen Khanh-Thanh-Thuy , Nguyen Luong-Han , Nguyen Ngoc-Lam , Phan Thi-Thuy-Nga , Zulfiqar Noor , Hoang Thi-Van , Ha Hai-Anh 
Published: November 2024

Abstract

Objective:
This study aimed to identify potential inhibitors from the beach morning glory (Ipomoea pes-caprae), a plant traditionally used for treating jellyfish stings, to counteract the effects of the venom.

Materials and Methods:
We utilized homology modeling to construct three-dimensional models of the jellyfish venom metalloproteinase and validated them using the structure analysis and verification server web-based tool for stereochemical quality assessment. Molecular docking studies were conducted using AutoDock Vina to screen compounds extracted from Ipomoea pes-caprae, focusing on their binding affinities toward the venom metalloproteinase. Key compounds, including quercetin and isochlorogenic acids A and B, were analyzed for their potential inhibitory effects.

Results:
The homology models of the jellyfish venom metalloproteinase were successfully constructed and validated, indicating reliable structural accuracy. The molecular docking studies identified several promising compounds from Ipomoea pes-caprae. Quercetin exhibited a binding energy of −8.8 kcal/mol, whereas isochlorogenic acids A and B showed binding energies of −8.5 and −9.0 kcal/mol, respectively. These compounds demonstrated strong interactions with key amino acids within the active site of the metalloproteinase, suggesting their efficacy in neutralizing the venom’s toxic effects.

Conclusion:
Our findings support the potential of compounds from Ipomoea pes-caprae as effective inhibitors of jellyfish venom metalloproteinase. This research validates the traditional use of this plant and lays the groundwork for further pharmacological and clinical studies. Future research should focus on in vitro and in vivo testing to confirm the efficacy of these compounds as new therapeutic agents for treating jellyfish stings.