bluuebunny/crossref_metadata_2025_split huggingface dataset:
20+ Years and alive with primary myelofibrosis: Phenotypic signature of very long‐lived patients
Authors: Penna Domenico , Lasho Terra L. , Finke Christy M. , Vallapureddy Rangit R. , Hanson Curtis A. , Ketterling Rhett P. , Pardanani Animesh , Gangat Naseema , Tefferi Ayalew 
Published: December 2018

AbstractIn the last decade, several prognostic models for primary myelofibrosis (PMF) have been introduced and shown to be effective in predicting overall survival. The main objective for this study was to identify clinical and genetic markers of very long (20+ years) survival in PMF. A total of 1282 patients with PMF were considered (median age 65 years, range 19‐92; 63% males); 26 (2%) patients (median age 51 years, range 28‐71; 38% males) survived their disease for at least 20 years (long‐lived patients) and 626 (49%) patients (median age 68 years, range 27‐92; 66% males) died within 5 years of their diagnosis (short‐lived patients). Multivariable logistic regression analysis identified 7 variables that were associated with survival beyond 20 years: age ≤ 70 years (P = .002); female sex (P = .03); hemoglobin level ≥ 10 g/dL for women and ≥ 11 g/dL for men (P = .03), leukocyte count ≤25 × 109/L (P = .009), platelet count ≥100 × 109/L (P = .002), circulating blasts <2% (P = .03) and absence of constitutional symptoms (P = .04). Five‐year mortality was independently predicted by high‐molecular risk mutations (P < .001); unfavorable or very high risk karyotype (P < .001); absence of type 1/like CALR mutation (P < .001); age > 70 years (P < .001); constitutional symptoms (P < .001); hemoglobin level < 10 g/dL for women and < 11 g/dL for men (P < .001); leukocyte count >25 × 109/L (P = .004); and circulating blasts ≥2% (P = .001). This study suggests that genetic risk factors in PMF are associated with early mortality while survival beyond 20 years could be predicted by easily accessible clinical variables, including age, sex, blood counts, and symptoms.
Peripheral blood biomarkers of early immune reconstitution in newly diagnosed multiple myeloma
Authors: Binder Moritz , Rajkumar S. Vincent , Lacy Martha Q. , Gertz Morie A. , Buadi Francis K. , Dispenzieri Angela , Hwa Yi L. , Fonder Amie , Hobbs Miriam , Hayman Suzanne R. , Zeldenrust Steven R. , Lust John A. , Russell Stephen J. , Leung Nelson , Kapoor Prashant , Go Ronald S. , Gonsalves Wilson I. , Kourelis Taxiarchis , Warsame Rahma , Kyle Robert A. , Kumar Shaji K. 
Published: December 2018

AbstractPeripheral blood biomarkers of tumor microenvironment and immune surveillance are independent prognostic factors in multiple myeloma. The timing and prognostic impact of immune reconstitution has been studied after autologous hematopoietic stem cell transplantation, less is known about its significance in newly diagnosed multiple myeloma. We studied absolute lymphocyte (ALC) and absolute monocyte (AMC) counts at the time of treatment initiation and 1 month thereafter in 771 newly diagnosed patients. Two hundred and thirty‐four patients (31%) had evidence of immune dysregulation at baseline (abnormal biomarkers). Eighty‐seven of these patients (37%) recovered normal biomarkers at 1 month (early immune reconstitution). The absence of immune dysregulation at baseline (compared to the presence thereof) was associated with better overall survival (HR 0.77, 95% CI 0.61‐0.97,P = 0.025, n = 771). The absence of immune dysregulation at 1 month (compared to the persistence or development thereof) was associated with better overall survival (HR 0.63, 95% CI 0.50‐0.80,P < 0.001, n = 771). Early immune reconstitution (compared to the persistence or development of immune dysregulation) was associated with better overall survival (HR 0.62, 95% CI 0.43‐0.92,P = 0.016, n = 771). Cytogenetic high‐risk disease was negatively, and treatment with immunomodulators positively, associated with early immune reconstitution. The presence or development of immune dysregulation in newly diagnosed multiple myeloma is an independent risk factor. The favorable impact of early immune reconstitution suggests immune dysregulation to be a potentially modifiable risk factor that may be exploited for therapeutic benefit.
Complex variation of trabecular bone structure in the proximal humerus and femur of five modern human populations
Authors: Doershuk Lily J. , Saers Jaap P. P. , Shaw Colin N. , Jashashvili Tea , Carlson Kristian J. , Stock Jay T. , Ryan Timothy M. 
Published: December 2018

AbstractObjectiveThis project investigates trabecular bone structural variation in the proximal humerus and femur of hunter‐gatherer, mixed‐strategy agricultural, medieval, and human groups to address three questions: (a) What is the extent of trabecular bone structural variation in the humerus and femur between populations with different inferred activity levels? (b) How does variation in the proximal humerus relate to variation in the proximal femur? (c) Are trabecular bone microstructural variables sexually dimorphic?MethodsThe proximal humerus and femur of 73 adults from five human groups with distinct subsistence strategies were scanned using a micro‐computed tomography system. Centralized volumes of interest within the humeral and femoral heads were extracted and analyzed to quantify bone volume fraction, trabecular thickness, trabecular separation, connectivity density, degree of anisotropy, and bone surface density.ResultsIn the humerus and femur, groups with the highest inferred activity levels have higher bone volume fraction and trabecular thickness, and lower bone surface density than those with lower inferred activity levels. However, the humeral pattern does not exactly mirror that of the femur, which demonstrates a steeper gradient of difference between subsistence groups. No significant differences were identified in trabecular separation. No consistent patterns of sexual dimorphism were present in the humerus or femur.ConclusionsReduced skeletal robusticity of proximal humeral and femoral trabecular bone corresponds with reduced activity level inferred from subsistence strategy. However, human trabecular bone structural variation is complex and future work should explore how other factors (diet, climate, genetics, disease load, etc.), in addition to activity, influence bone structural variation.
Economic valuation of biodiversity in South Asia: The case of Dachigam National Park in Jammu and Kashmir (India)
Authors: Bhat Mohammad Younus , Bhatt Mohammad Sultan 
Published: December 2018

AbstractBiodiversity needs our attention because humans receive a wide range of direct and indirect benefits. Valuation of biodiversity is important to establish the importance of use and non‐use values of biological resources and cost of ignoring them. Against this backdrop, the aim of this study is to capture the recreational value of the national park biodiversity while employing travel cost method. To this end, the value of the economic benefits generated by sustainable management of Dachigam National Park in Jammu and Kashmir (India) is estimated using data from 301 visitors from different parts of the country. Data are analysed using count data models, and results reveal that travel cost method is suitable for valuation of various use values generated by environmental resources such as national parks. Estimated results show that consumer surplus per visitor per visit in present study is equal to Rs. 12,470 (US$197), which translates into an annual monetary recreational value of about Rs. 247,614,828 (approximately US$3,930,395). Demand for tourism services is also found to be fairly insensitive to travel cost/price. Therefore, an increase in entry fee and redistribution of proceeds can improve the physical and financial management of the park.
Adenosine 2a Receptor Signal Blockade of Murine Autoimmune Arthritis via Inhibition of Pathogenic Germinal Center–Follicular Helper T Cells
Authors: Schmiel Shirdi E. , Kalekar Lokesh A. , Zhang Na , Blankespoor Thomas W. , Robinson Londyn J. , Mueller Daniel L. 
Published: December 2018

ObjectiveCD4 germinal center (GC)–follicular helper T (Tfh) cells are important in the pathogenesis of autoimmune arthritis. Previous studies have shown that adenosine 2a receptor (A2aR; Adora2a) signaling can divert CD4 T cells away from the GC‐Tfh cell lineage during the primary response to foreign antigens. This study was undertaken to examine the effects of A2aR signaling on CD4 T cells during the recognition of self antigen in a murine model of autoimmune arthritis.MethodsWild‐type and Adora2a‐deficient mouse KRN T cell receptor–transgenic CD4 T cells specific for glucose‐6‐phosphate isomerase (GPI)/I‐Ag7 were transferred into immunodeficient Tcra−/− I‐Ag7–expressing mice to induce arthritis. Recipients were then treated with either the selective A2aR agonist CGS‐21680 (CGS) or phosphate buffered saline alone. Severity of disease, autoantibody titers, KRN T cell numbers and phenotype, and GPI‐specific isotype class–switched plasmablasts were tracked.ResultsCGS treatment inhibited the development of arthritis and differentiation of KRN GC‐Tfh cells, blocked the appearance of high‐affinity GPI‐specific and IgG1 isotype class–switched polyclonal plasmablasts, and led to a reduction in serum titers of anti‐GPI IgG1. In addition, therapeutic administration of CGS after the onset of arthritis blocked further disease progression in association with reductions in the number of KRN GC‐Tfh cells and anti‐GPI IgG1 serum titers.ConclusionStrong A2aR signaling diverts autoreactive CD4 T cell differentiation away from the GC‐Tfh cell lineage, thus reducing help for the differentiation of dangerous autoreactive B cells that promote arthritis. These data in a mouse model of autoimmune arthritis suggest that A2aR and its downstream signaling pathways in CD4 T cells may be promising therapeutic targets for interfering with potentially dangerous autoreactive GC‐Tfh cell differentiation.
Construction of a Luminogen Exhibiting High Contrast and Multicolored Emission Switching through Combination of a Bulky Conjugation Core and Tolyl Groups
Authors: Duan Yuxin , Ma Huili , Tian Haiyan , Liu Jing , Deng Xuebin , Peng Qian , Dong Yong Qiang 
Published: December 2018

AbstractStimuli‐responsive luminogens may find application in highly sensitive sensors, memories and security inks. However, few examples exhibiting both high contrast and multi‐colored emission switching have been reported due to the absence of a molecular design strategy. Through combination of large conjugation core and peripheral phenyl rings, we obtained ditolyldibenzofulvene (1). Luminogen 1 is AIE active and exhibits tetracolored emission depending on its morphology. Its three single crystals emit blue, yellow and dark orange light upon excitation, exhibiting a maximal emission of 461 nm, 545 nm and 586 nm, respectively, and its amorphous solid emits at 557 nm. All the four aggregates exhibit enhanced emission intensity at lower temperature, but only the orange‐emissive crystals exhibit blue‐shifted emission. The emission of 1 can be switched reversibly between any two of the four states through morphology tuning. Finally, the potential application of 1 in optical data storage was also investigated.
Integration of Derivative Control on SIPIC in Motor Speed Control
Authors: Hoo Choon Lih , Wong Jien 
Published: December 2018

AbstractThe proportional–integral–derivative (PID) controller is the most commonly used controller in control application due to its simplicity. However, the control output may exceed the plant input limit which eventually deteriorates the system performance. This is known as a windup phenomenon, which causes large overshoot, long settling time and instability in the control system. Various anti‐windup methods have been introduced to overcome the windup phenomenon such as the Steady‐State Integral Proportional‐Integral Controller (SIPIC). Due to the coupling of the proportional, integral and derivative tuning gains, it is difficult to tune for non‐overshoot and short settling time to coexist in a PID. With decoupling, a greater range of tuning gains can be applied to control the rising slope without disturbing the damping state. Currently, SIPIC with decoupling effect has only been studied for the proportional and integral tuning gains. This paper presents the effect of integrating derivative control on SIPIC in motor speed control. SIPIC+D shows better speed control on a direct current motor under no‐load and loading conditions compared with other existing anti‐windup added with derivative control.
SOX11 regulates apoptosis and cell cycle in hepatocellular carcinoma via Wnt/β‐catenin signaling pathway
Authors: Liu Zhi , Zhong Yang , Chen Yu Jian , Chen Hui 
Published: December 2018

AbstractHepatocellular carcinoma (HCC) is the most common type of liver cancer with high mortality. Identifying key molecules involved in the regulation of HCC development is of great clinical significance. SOX11 is a transcription factor belonging to group C of Sry‐related high mobility group box family whose abnormal expression is frequently seen in many kinds of human cancers. Here, we noted that the expression of SOX11 was decreased in human HCC tumors compared with that in matched normal tissues. Overexpression of SOX11 promoted growth inhibition and apoptosis in HCC cell line HuH‐7. Mechanistically, SOX11 enhanced the expression of nemo‐like kinase and the phosphorylation of TCF4, thereby blunting the activation of oncogenic Wnt/β‐catenin signaling pathway in HuH‐7 cells. Finally, SOX11 was also found to sensitize HuH‐7 cells to chemotherapy drugs cisplatin and 5‐fluorouraci. Therefore, our study identifies SOX11 as a potential tumor suppressor in HCC and may hopefully be beneficial for the clinical diagnosis or treatment of HCC.
Structured representation of monitored occupancy data
Authors: Taheri Mahnameh , Mahdavi Ardeshir 
Published: December 2018

AbstractStrukturierte Darstellung von nutzerbezogenen Gebäudedaten. Ingenieure und Bauphysiker benötigen qualitativ hochwertige und detaillierte Daten für die systematische Unterstützung von Gebäudeentwurf und ‐betrieb. Derartige Daten werden unter anderem benötigt, um die für die Gebäudesimulation notwendigen Modelle der Nutzerpräsenz und des Nutzerverhaltens entwickeln und validieren zu können. Dabei ist eine wichtige Voraussetzung für den Datenaustausch das Vorhandensein geeigneter Ontologien und standardisierter Datenformate. Der vorliegende Beitrag präsentiert eine Ontologie sowie ein hierarchisches Datenformat zur Darstellung multipler nutzerbezogener Gebäudedaten beliebiger Größe und Komplexität.
Honokiol induces apoptosis of lung squamous cell carcinoma by targeting FGF2‐FGFR1 autocrine loop
Authors: Cen Mengyuan , Yao Yinan , Cui Luyun , Yang Guangdie , Lu Guohua , Fang Liangjie , Bao Zhang , Zhou Jianying 
Published: December 2018

AbstractLung squamous cell carcinoma (SCC) accounts for a considerable proportion of lung cancer cases, but there is still a lack of effective therapies. FGFR1 amplification is generally considered a promising therapeutic target. Honokiol is a chemical compound that has been proven to be effective against various malignancies and whose analog has been reported to target the mitogen‐activated protein kinase family, members of a downstream signaling pathway of FGFR1. This was an explorative study to determine the mechanism of honokiol in lung SCC. We found that honokiol induced apoptosis and cell cycle arrest in lung SCC cell lines in a time‐ and dose‐dependent manner. Honokiol also restricted cell migration in lung SCC cell lines. Moreover, the expression of FGF2 and the activation of FGFR1 were both downregulated by honokiol. Pharmacological inhibition and siRNA knockdown of FGFR1 induced apoptosis in lung SCC cells. Our in vivo study indicated that honokiol could suppress the growth of xenograft tumors, and this effect was associated with the inhibition of the FGF2‐FGFR1 signaling pathway. In conclusion, honokiol induced cell apoptosis in lung SCC by targeting the FGF2‐FGFR1 autocrine loop.
The Accumulation of Risk and Essential Elements in Edible Mushrooms Chlorophyllum rhacodes, Suillus grevillei, Imleria badia, and Xerocomellus chrysenteron Growing in the Czech Republic
Authors: Šíma Jan , Vondruška Jan , Svoboda Lubomír , Šeda Martin , Rokos Lukáš 
Published: December 2018

AbstractRisk and essential elements were determined in fruiting bodies of wild growing edible mushrooms Chlorophyllum rhacodes, Suillus grevillei, Imleria badia, and Xerocomellus chrysenteron collected in an unpolluted site in South Bohemia, the Czech Republic. The elements were also determined in underlying soils and the bioconcentration factors were calculated. The analyses revealed that C. rhacodes accumulated Ag, Cu, Rb, Se, Zn, As, Cd, and Tl. On the other hand, S. grevillei accumulated Cd, Rb, Ag, Se, and Cs. I. badia and X. chrysenteron strongly accumulated Rb, Cs, and Ag; these species showed the ability to accumulate Cu and Zn as well. Contents of detrimental CrVI were in all cases below the quantification limit (0.003 mg kg−1 dry matter). Studied mushroom species (mainly C. rhacodes) accumulated some toxic elements. However, no considerable effect on human health is expected since they are usually consumed as a delicacy and do not represent a major component of diet.
Immunologic characterization of patients with chronic mucocutaneous candidiasis disease
Authors: Khalsa Kiranjit K. , Yang Qi , Shen Xiaofei , Pasha M. Asghar , Celestin Jocelyn 
Published: December 2018

Key Clinical MessageEven if initial immunologic screen is normal, a high index of suspicion for immunodeficiency should guide the evaluation and management of patients with recurrent episodes of mucocutaneous candidiasis. Although rare, a diagnosis of chronic mucocutaneous disease should always be considered in order to improve their outcome.
Separation of eight bedaquiline analogue diastereomers by HPLC on an immobilized polysaccharide‐based chiral stationary phase
Authors: Jiang Shenmeng , Wu Chengjun , Yu Jia , Sun Tiemin , Guo Xingjie 
Published: December 2018

AbstractThe high‐performance liquid chromatography (HPLC) is a powerful method in the area of stereoisomer separation. In this study, separation of eight bedaquiline analogue diastereomers (compounds 1‐8) was first examined on a cellulose tris‐(3,5‐dichlorophenylcarbamate) chiral stationary phase, ie, Chiralpak IC in the normal phase mode. The influences of organic modifier types, alcohol content, and column temperature on diastereoseparation were evaluated. Under the optimum chromatographic conditions, all the analyte stereoisomers were successfully separated. The experimental results revealed the great influence of analytes' structures on the diastereoseparation with Chiralpak IC. In addition, thermodynamic parameters were calculated by Van't Hoff plots, and correlative chiral recognition mechanisms were discussed further.
Experimental Methods in Chemical Engineering: Nuclear Magnetic Resonance
Authors: Rigamonti Marco G. , Gatti Francesco G. , Patience Gregory S. 
Published: December 2018

AbstractNuclear magnetic resonance (NMR) spectroscopy measures free induction decay (FID) signals that atomic nuclei emit when excited by a radio‐frequency (RF) pulse in a static magnetic field. The Fourier‐transformed spectrum shows chemically shifted peaks, area intensity, and multiplicity, which give information on molecular structure, bonds, functional groups, and purity. Web of Science Core Collection indexed 46 000 articles that mentioned NMR in 2016 and 2017. The VosViewer software grouped the research into 5 clusters: solid‐state analysis including metabolomics; biology with in‐vitro and antibacterial applications; coupled analytical techniques to identify crystal structure for which x‐ray diffraction and density functional theory figure prominently; liquid‐state analysis for polymers, aqueous solutions, nano‐particles, and drug delivery; and chemosensors. Researchers publishing in The Canadian Journal of Chemical Engineering focus most on: liquid‐state NMR to characterize polymers, branching, and monomers; quantify conformation, reaction kinetics, and equilibrium; and assess surfactant stability, ionic liquids, and composition. We introduce the theory behind NMR spectroscopy and common applications in chemistry and material science. We highlight the strength and limitations, sources of error, and the detection limit for this analytical technique, as manufacturers develop massive magnets for high‐resolution spectra (1 GHz), and benchtop NMR for real‐time, in‐situ analysis (80 MHz).
Visualization of the secondary phase in LiFePO4 ingots with advanced mapping techniques
Authors: Liu Yulong , Banis Mohammad Norouzi , Xiao Wei , Li Ruying , Wang Zhiqiang , Adair Keegan R. , Rousselot Steeve , Sauriol Pierre , Dollé Mickaël , Liang Guoxian , Sham Tsun‐Kong , Sun Xueliang 
Published: December 2018

AbstractLiFePO4 has been widely used as a cathode material in lithium ion batteries. However, some impurity phases existing in LiFePO4 have a significant influence on its electrochemical performance. Therefore, detection of the impurity phases is necessary for the manufacturer in order to improve the quality of LiFePO4. In particular, visualization of the impurity and secondary phase distributions immersed in the bulk LiFePO4 crystal can help to understand the origin of the impurity and secondary phases, providing clear guidance towards the synthesis of high purity LiFePO4. The results show that with the combination of Raman and EDS, we are capable of identifying the low melting lithium phosphate phase in LFP ingot. Through micro XRF mapping, more detailed information about the LFP materials after carbon coating are observed. The secondary phases are easily defined due to the high sensitivity of this technology.
Modelling of phase equilibria of LiFePO4‐FePO4 olivine join for cathode material
Authors: Phan Anh Thu , Gheribi Aïmen E. , Chartrand Patrice 
Published: December 2018

AbstractA thermodynamic model for the FePO4‐LiFePO4 olivine join has been developed in order to provide support for the understanding of the charge transport behaviour within the cathode material during the battery operation. The Gibbs energy model for the olivine solution is based on the compound energy formalism with long‐range‐order and has been calibrated using the CALPHAD method, permitting the computation of phase equilibria by Gibbs energy minimization techniques. The model can simultaneously reproduce the reported eutectoid reaction, the 3 low‐temperature miscibility gaps, the enthalpy of mixing, and the change of the voltage plateau with temperature during the delithiation process, in agreement with the available experimental data. The spinodal decomposition, which is possibly associated with fast charge transport within the cathode material, involves up to two sub‐spinodal decompositions. Hence, the unique low‐temperature miscibility gap of this system is considered as a blend of the two sub‐miscibility gaps.