bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-particulate Drug Delivery Systems of Fenofibric Acid: Optimization of Formulation Using Statistical Experimental Design
Authors: Bala Vishnu Priya Mukkala  , Murthy T.E.G.K  , Prameela Rani Avula  
Published: June 2018

The objective of the present research work was to develop a multi-particulate modified release system of Fenofibric acid using Wurster (Bottom spray fluid bed coating) process. Impact of various formulation variables was assessed by using statistical interpretation such as ANOVA. A 33 (three factor, three level) face centered central composite design was employed to study the effect of independent variables (concentration of ER Polymer, plasticizer and pore former), on dependent variables (drug release at 2.5th h & 6th h). Optimization of the formulation variables was done by fitting experimental data to the software program (Design Expert). The design space for formulation variables was developed. Fabricated pellets were characterized for various physico-chemical parameters. In vitro release data of the optimized formulation was fitted into various kinetic equations. The optimized formulation showed a desired drug release at both 2.5th h and 6th h as 17.5 ± 2.28% & 87.1 ± 0.75% respectively. The drug release from the capsules followed first order kinetics and controlled by non fickian transport. The information acquired in this study recommends that the multi-particulates of Fenofibric acid can be effectively intended to give a delayed release of Fenofibric acid and thus enhanced bioavailability.
Curricula in Teacher Education for Diversity in the University of Namibia
Authors: Sichombe Beatrice Sinyama 
Published: June 2018

Namibia’s classroom compositions are diverse. Its policies on diversity reflect international practices of achieving Education for All. It advocates for teacher education that is responsive to the country’s needs. What is unknown is what a socio-cultural curriculum means in Namibian teacher education. This article focuses on the nature of the UNAM’s B.Ed. curriculum and how students learn its contents. I argue that teacher education for diversity should go beyond traditional teacher education programmes. Its curricula should adopt a socio-cultural view. Coursework and teaching practice should reflect the needs of learners and society. Data collection consisted of documents, and interviews. Content analysis was used. Findings revealed that teaching practice lacked dedication in regard to diversity teaching. Consequently, the B.Ed. Programme partially equipped students with competencies to teach diverse learners because coursework alone cannot suffice. The study contributes to knowledge of what a socio-cultural curriculum means in Namibian teacher education.
A New Method of Backup-Cutter Layout To Extend Bit Life Without Sacrificing Rate of Penetration
Authors: Chen Shilin , Khlefat Yazan , Cleboski Chris , Anderle Seth , Maouche Zakaria 
Published: June 2018

Summary
This paper discusses a new and general method of backup-cutter layout to extend bit life without sacrificing rate of penetration (ROP) and two field-case studies. This method includes the following aspects:
Ensuring backup cutters do not cut or only partially cut when their primary cutters experience little-to-no wear and when the penetration per revolution of the bit does not exceed an expected value. This aspect is enabled by allowing backup cutters to have a minimal critical depth of cut that is greater than the depth of cut of the primary cutters. Ensuring that backup cutters act as active cutters when the primary cutters’ wear depth is equal to or greater than the underexposure of the backup cutters. This aspect is enabled by allowing each backup cutter to be rotationally behind its primary cutter by approximately 150° or greater. The underexposure of each backup cutter relative to its primary cutter is calculated carefully on the basis of the primary cutter's wear and drilling conditions.
Topical 1% Propranolol in Liposomal Gel: A New Adjuvant Tool for Chronic Leprosy Ulcers
Authors: Abdelmaksoud Ayman , Bonamonte Domenico , Giudice Giuseppe , Filoni Angela , Vestita Michelangelo 
Published: June 2018

Objective:To evaluate the effects of 1% topical propranolol in liposomal gel in 3 patients with plantar ulcers.Methods:We enrolled 3 patients with 3 ulcers who had completed the WHO recommended treatment regimen. The ulcers were cleaned with sterile normal saline, and 1% topical propranolol in liposomal gel was applied 2 times/day for 3 months, or less if complete healing was reached before. Assessment of ulcer re-epithelization was recorded at baseline, 6 weeks, and 3 and 6 months after initiation of treatment.Results:Response in the form of granulation tissue formation started by the second week. Substantial reduction in size subsequently continued over the next 3 months. Two of the 3 patients showed complete healing of the ulcers at the 6 months follow up. In the 3rdpatient, the ulcer showed only modest signs of healing. Surprisingly, in all patients, the sensory function was restored, particularly in terms of pain. Some motor functional recovery at the ulcer site and surrounding tissue was also documented.Conclusion:To the best of our knowledge, this is the first trial of topical propranolol for the treatment of trophic ulcers of leprosy. This may represent a promising adjuvant therapy for leprosy ulcers, including ulcers of older age. Further studies are warranted with a larger number of patients and a longer period of follow up to determine the ideal candidates and to identify clinical factors predictive of response.
Daclatasvir combined with asunaprevir is a cost-effective and cost-saving treatment for hepatitis C infection in China
Authors: Chen Wen , Ward Thomas , Tan Mai Ping , Yan Jing , Wang Peter Feng , Wygant Gail D , Gordon Jason 
Published: June 2018

Aim:
To evaluate the cost–effectiveness of the novel all-oral direct-acting antiviral regimen daclatasvir + asunaprevir (DUAL), versus interferon-based regimens for the treatment of chronic hepatitis C virus genotype 1b infection.
Methods:
Inputs for a lifetime Markov model were sourced from clinical trials and published literature. Outputs include disease management costs, life expectancy, quality-adjusted life-years and cost–effectiveness. Sensitivity analyses assessed the drivers of cost–effectiveness and sustained virologic response thresholds at which DUAL is cost-saving.
Results:
DUAL was associated with discounted incremental quality-adjusted life-years of 1.29–3.85 and incremental life-years of 0.85–2.59 per patient, with discounted lifetime cost savings of USD$1415–8525. Associated sustained virologic response rates could fall to 45.1–84.8%, while remaining dominant.
Conclusion:
Treatment with DUAL provides significant clinical benefit, while accruing lower lifetime costs.
Editorial Bitácora arquitectura 37 "Error"
Authors: López Uribe Cristina 
Published: June 2018

<p>A pesar de que sabemos que los errores están siempre presentes -y tienden a multiplicarse- existe muy poca información acerca del error en relación con la arquitectura. Los discursos históricos, teóricos y anecdóticos se suelen enfocar en una narrativa basada en el triunfo, en los grandes logros. Estamos obsesionados con explicar la forma en la que todo puede salir bien, mientras olvidamos explicar que todo suele salir mal. Mientras más avances se logran en la tecnología y más al alcance de la sociedad están, la ilusión de perfección que parecen prometer sólo incrementa la frustración generalizada al encontrar múltiples errores en nuestro camino. Murphy y sus leyes nos han enseñado que siempre que algo pueda salir mal, saldrá mal: vivimos los errores cotidianamente.</p>
Interpretación del Poema Plástico de Mathias Goeritz (1953)
Authors: Santoyo García Galiano Julián , Mahmoud Makki Hornedo Laila Carmen , Santoyo García Galiano Miguel Ángel 
Published: June 2018

<p>En este trabajo realizamos un estudio detallado con el fin de interpretar el poema plástico de Mathias Goeritz. El estudio consiste en tres tipos de análisis: uno filológico, uno numérico-computacional y uno formal. Mediante el análisis filológico estudiamos las posibles similitudes entre los trazos y formas del poema plástico con varios sistemas de<br />escritura, antiguos y modernos, y con los cuales el artista pudo haber convivido cercanamente. Asimismo, revisamos la posible existencia de palabras o frases en varios de los idiomas cuyo sistema de escritura es aquí analizado. Para el análisis numérico computacional utilizamos un software de inteligencia artificial OCR para estudiar las formas gráficas<br />del poema en relación con los sistemas de escritura e idiomas estudiados mediante el análisis filológico. En el análisis formal utilizamos varias técnicas de análisis gráfico y contextual a fin de identificar posibles palabras y frases en idioma español. Con base en nuestros resultados, y tomando en cuenta el contexto artístico de la época en la cual fue elaborada la obra, concluimos que el poema plástico es, en realidad, un manifiesto plástico escrito en idioma español en contra de las políticas artísticas oficiales de la época y sus representantes, Diego Rivera y David Alfaro Siqueiros, y proponemos la transcripción del poema en idioma español.</p>
PPGD: o novo programa de Pós-Graduação em design
Authors: Mourthé Claudia , Pires Julie De Araújo 
Published: June 2018

O Programa de Pós-graduação em Design foi reconhecido e recomendado pela CAPES, na 164ª Reunião do CTC-ES, em 3 de junho de 2016, integra o Sistema Nacional de Pós-graduação e é credenciado pela CAPES/MEC, cadastrado na Plataforma Sucupira. O programa oferece vagas anuais para ingresso no Mestrado Acadêmico em Design, com enfoque teórico-prático. Entretanto em 3 de outubro de 2016, o prédio da Reitoria onde o PPGD estava locado, pegou fogo comprometendo toda a estrutura física do programa ainda em fase de estruturação. Mas seguimos em frente e o Projeto do Programa vem sendo implantando e a 1ª turma iniciou em agosto de 2017. Com um conjunto nuclear de disciplinas calcadas na maleabilidade e densidade das metodologias de pesquisa em “Design Visual”, como área de concentração o PPGD visa desenvolver projetos de pesquisa com monografias de conclusão do curso, a partir da identificação de demandas sociais, culturais e tecnológicas na sociedade como um todo, aplicadas a demanda no campo do design.Nesse sentido, uma dinâmica renovadora é assegurada na estrutura curricular do PPGD tanto pela mutabilidade e flexibilidade dos conteúdos programáticos com enfoque teórico prático e pela atualização contínua aportada pelo dinamismo das atividades de investigação desenvolvida nos projetos de pesquisa desenvolvidos.
Detection of Leukemia Using Image Processing
Authors: Sivasangari A. , Sasikumar G. 
Published: June 2018

Leukemia disease is one of the leading causes of death among human. Its cure rate and prognosis depends mainly on the early detection and diagnosis of the disease. At the moment, identification of blood disorders is through visual inspection of microscopic images by examining changes like texture, geometry, colour and statistical analysis of images . This project aims to preliminary of developing a detection of leukemia types using microscopic blood sample using MATLAB. Images are used as they are cheap and do not expensive for testing and lab equipment.
Optimization of WMN Performance for Different Propagation Environment
Authors: Qadir Reshi Isfaq , Saini Anuradha 
Published: June 2018

Wireless mesh networks are multihop systems in which contrivances avail each other in transmitting packets through the network, especially in arduous conditions. We can drop these ad hoc networks into place with minimal preparation, and they provide a reliable, flexible system that can be elongated to thousands of contrivances. The wireless mesh network topology developed is a point-to-point-to-point, or peer-to-peer, system called an ad hoc, multi-hop network. A node can send and receive messages, and in a mesh network, a node withal functions as a router and can relay messages to its neighbours. A mesh network offers multiple redundant communications paths throughout the network. If one link fails for any reason, the network automatically routes messages through alternate paths. In a mesh network, we can abbreviate the distance between nodes, which dramatically increases the link quality. If we reduce the distance by a factor of two, the resulting signal is at least four times more puissant at the receiver. This makes links more reliable without incrementing transmitter power in individual nodes. In a mesh network, we can elongate the reach, integrate redundancy, and amend the general reliability of the network simply by integrating more nodes. One of the most astronomically immense issues in routing is to providing copacetic performance while scaling the wireless mesh network. It is fascinating, however, to investigate what transpires when routing nodes are expanded in different propagation environment and how that affects routing metrics. In this thesis, we examine the utilization of different proactive, reactive and hybrid protocols in such a way so that we may be able to build a cost function which avails in culling the finest grouping of routing protocols for a particular urban wireless mesh network. The key parameters are network throughput and average end to culminate delay. The performance of Bellman ford, DYMO, STAR and ZRP protocols have been examined with different node densities. A non-linear cost function equation has been proposed corresponding to each routing parameter taken. Bitrate is taken as constant (CBR).
Komunikasi Partisipatif Masyarakat Industri dalam Mendukung Branding Kota Madiun
Authors: Dewi Mutia , Nulul Noer Ayufika 
Published: June 2018

Industrial society in madiun city contribute in supporting of Madiun city branding. This proved by the participate position in implementation and utilization of results. Madiun industrial society show the competitive value to global society that usually earn achievement from the exhibition that helds from many various events. This competitive value is suitable with creation of Madiun city branding as 'Kota Gadis' which combinate from three education aspects. The form of communication participation in supporting branding madiun city is heteroglasia,dialogis, poliponi, dan karnaval
Possibilities and conditions for the implementation of integration solutions in public transport on the example of a dobule-city area Slupsk-Ustka
Authors: Adamkiewicz Tomasz 
Published: June 2018

The article presents the problems of integration solutions in mass transport. This topic is based on the connections between Słupsk and Ustka, which is linked by a mutual cooperation agreement. Both towns form a dobule-city area, which aims to conduct a common regional policy. The aim of this article is to demonstrate the legitimacy of integrating the mass transport system operating in this area.
The task of integration processes on the public transport market is to provide the inhabitants of a region with a reliable transport system, streamlining the movement by a transparent tariff, adjusting the network of connections to the demand and shortening the travel time. It is necessary to construct a transport offer in such a way as to promote the attractiveness of public transport, in particular against the background of individual motorisation. The premise for building an integrated transport system should be all postulates of inhabitants of a region.
The results of the research project carried out prove that the issue of integrating public transport in this area is still valid. Their comparison with the proposed integration assumptions indicates that these solutions are an opportunity to improve its functioning. Implementation of the assumptions linking urban transport in Słupsk with mass transport in the Słupsk-Ustka corridor would contribute to strengthening the cooperation of both cities and improving their tourist attractiveness. However, it requires proper cooperation of local governments, taking into account all the travel postulates of the inhabitants of the region. The administrative boundaries can not constitute barriers to smooth movement between these cities.
Pekerjaan Sosial dengan Anak dan Keluarga
Authors: Apsari Nurliana Cipta 
Published: June 2018

Dalam bekerja dengan anak, seorang pekerjasosial harus mendasarkan intervensinya kepadakepentingan terbaik untuk anak. Konteks yang paling dekat dan mempengaruhikehidupan seorang anak, menurut model iniadalah keluarga. Keluarga adalah tempat utamadan pertama dalam kehidupan seorang anak.Sebuah keluarga dapat berarti keluarga besar,keluarga inti, keluarga orang tua tunggal, keluargadengan orang tua yang berbeda suku, agama danras. Keluarga orang tua tunggal pun beragam,ada yang karena bercerai, meninggal atau tidakdiketahui keberadaan salah satu orang tuanya.Hal-hal tersebut menunjukkan betapa keluarga itumengalami dinamika yang sangat tinggi yangdapat mempengaruhi kesejahteraan anak-anakyang diasuh dalam keluarga tersebut.
Blockchain Use Cases and Their Feasibility
Authors: Zīle Kaspars , Strazdiņa Renāte 
Published: June 2018

Abstract
The goal of the paper is to provide a vague summary of currently existing blockchain use cases in the information technology industry. Respective use cases have been examined in already existing scientific papers, Master Theses, industry white papers and blogs of industry experts. The paper also contains a description of blockchain main technological aspects and working principles, which allows making the assessment of the presented use cases. For each use case respective companies or organisations are added that are applying or testing the given solution. Due to research limitations the paper should not be considered an exhaustive blockchain use case description.
The paper also provides short introduction into a feasibility analysis of specific blockchain use case. The authors describe the basic steps of potential idea evaluation with regards to blockchain main aspects. It helps understand the necessity for development of a detailed blockchain feasibility model.
Containers for Virtualization: An Overview
Authors: Silva Vitor Goncalves da , Kirikova Marite , Alksnis Gundars 
Published: June 2018

Abstract
Virtualization has enabled the commoditization of cloud computing, as the hardware resources have become available to run different environments and share computing resources amongst different enterprises. Two technology types are commonly used in virtualization of hardware, namely, hypervisor and container. The present paper concerns only container technologies.
A comprehensive overview of the container technologies for virtualization and the dynamics of their popularity have not been available yet. Without such an overview, the informed fast choice of technologies is hindered. To fill this knowledge gap, a systemic literature review was conducted to reveal the most popular container technologies and the trends in their research.
Object-Relational Database Structure Model and Structure Optimisation
Authors: Auziņš Ainārs , Eiduks Jānis , Vasiļevska Alīna , Dzenis Reinis 
Published: June 2018

Abstract
During object-relational database physical structure design, problems are caused by three factors: ambiguity of transformations of conceptual model, multiplicity of quality assessment criteria, and a lack of constructive model. In the present study a constructive hierarchical model of physical database structure has been developed. Implementations are used in XML, SQL and Java languages. Multi-criterial structure optimisation method has also been developed. Structure variation space is generated using transformation rule database. Prototype has been implemented within the framework of the research.
Performance Comparison of Java EE and ASP.NET Core Technologies for Web API Development
Authors: Kronis Kristiāns , Uhanova Marina 
Published: June 2018

Abstract
The paper describes the implementation of organic benchmarks for Java EE and ASP.NET Core, which are used to compare the performance characteristics of the language runtimes. The benchmarks are created as REST services, which process data in the JSON format. The ASP.NET Core implementation utilises the Kestrel web server, while the Java EE implementation uses Apache TomEE, which is based on Apache Tomcat. A separate service is created for invoking the benchmarks and collecting their results. It uses Express with ES6 (for its async features), Redis and MySQL. A web-based interface for utilising this service and displaying the results is also created, using Angular 5.
Sentiment Analysis in Latvian and Russian: A Survey
Authors: Vīksna Rinalds , Jēkabsons Gints 
Published: June 2018

Abstract
Social networking sites such as Facebook, Twitter and VKontakte, online stores such as eBay, Amazon and Alibaba as well as many other websites allow users to share their thoughts with their peers. Often those thoughts contain not only factual information, but also users’ opinion and feelings. This subjective information may be extracted using sentiment analysis methods, which are currently a topic of active research. Most studies are carried out on the basis of texts written in English, while other languages are being less researched. The present survey focuses on research conducted on the sentiment analysis for the Latvian and Russian languages.
Smooth Non-increasing Square Spatial Extents of Filters in Convolutional Layers of CNNs for Image Classification Problems
Authors: Romanuke Vadim V. 
Published: June 2018

Abstract
The present paper considers an open problem of setting hyperparameters for convolutional neural networks aimed at image classification. Since selecting filter spatial extents for convolutional layers is a topical problem, it is approximately solved by accumulating statistics of the neural network performance. The network architecture is taken on the basis of the MNIST database experience. The eight-layered architecture having four convolutional layers is nearly best suitable for classifying small and medium size images. Image databases are formed of grayscale images whose size range is 28 × 28 to 64 × 64 by step 2. Except for the filter spatial extents, the rest of those eight layer hyperparameters are unalterable, and they are chosen scrupulously based on rules of thumb. A sequence of possible filter spatial extents is generated for each size. Then sets of four filter spatial extents producing the best performance are extracted. The rule of this extraction that allows selecting the best filter spatial extents is formalized with two conditions. Mainly, difference between maximal and minimal extents must be as minimal as possible. No unit filter spatial extent is recommended. The secondary condition is that the filter spatial extents should constitute a non-increasing set. Validation on MNIST and CIFAR- 10 databases justifies such a solution, which can be extended for building convolutional neural network classifiers of colour and larger images.
The Morphometry of the Lumbar Costiform Process
Authors: Mihaela Bizadea , Cosmin Nişcoveanu , Petru Bordei 
Published: June 2018

Abstract
The length of the lumbar costiform process was determined and compared at the right and left side of the body, according to sex, on 32 cases. Differences were found, some were significant, depending on the side of the body. For both sexes, a gradual growth of the general average for the right and left lumbar costiform process was observed only for the first three vertebras, the value at the level of the last two lumbar vertebras being smaller than at the level of the L3 vertebra.