bluuebunny/crossref_metadata_2025_split huggingface dataset:
PREHABILITATION FOR FRAIL PATIENTS UNDERGOING HIP AND KNEE ARTHROPLASTY: JOINT PREP FEASIBILITY STUDY FOR A RANDOMIZED CONTROLLED TRIAL
Authors: Khalid T. , Shlomo Y. B. , Bertram W. , Culliford L. , enderson E. , Jepson M. , Johnson E. , Palmer S. , Whitehouse M. , Wylde V. 
Published: November 2024

IntroductionApproximately 20-25% of patients having joint replacement in the UK have moderate-severe frailty. Frailty is associated with poorer outcomes after joint replacement. Targeting frailty pre-operatively with exercise and protein supplementation could improve post-operative outcomes. Prior to conducting a randomised controlled trial (RCT), a feasibility study was necessary to inform trial design and delivery.MethodWe conducted a randomised feasibility study with embedded qualitative work. Patients aged ≥65 years, frail and undergoing THR or TKR were recruited from three UK hospitals. Participants were randomly allocated on a 1:1 ratio to the intervention or usual care group. The intervention group had a 1:1 appointment with a physiotherapist and were provided with a home-based, tailored daily exercise programme and a daily protein supplement for 12 weeks before their operation, supported by six telephone calls from a physiotherapist. Questionnaires were administered at baseline and 12 weeks after randomisation. Interviews were conducted with 19 patients. Feasibility outcomes were eligibility and recruitment rates, intervention adherence, and acceptability of the trial and the intervention.Result411 patients were sent a screening pack. Of the 168 patients who returned a screening questionnaire, 79 were eligible and consented to participate, and 64 were randomised. Of the 33 participants randomised to the intervention, 26 attended the intervention appointment. Eighteen participants (69%) received all six intervention follow-up telephone calls. Nineteen participants completed an intervention adherence log; 13 (68%) adhered to the exercise programme and 11 (58%) adhered to the protein supplementation. The overall retention rate was 86% at 12 weeks. The 12-week follow-up questionnaire was returned by 84% of participants who were sent a questionnaire. Interviews found that the trial and intervention were generally acceptable, but areas of potential improvements were identified.ConclusionThis study demonstrated that a larger study is possible and has identified improvements to optimise the design of a RCT.
COMPARISON OF THE GLENOID INDEX BY COMPUTED TOMOGRAPHY WITH MAGNETIC RESONANCE IMAGING
Authors: Ahmed N. A. , Narendran K. , Ahmed N. A. 
Published: November 2024

IntroductionAnterior shoulder instability results in labral and osseous glenoid injuries. With a large osseous defect, there is a risk of recurrent dislocation of the joint, and therefore the patient must undergo surgical correction. An MRI evaluation of the patient helps to assess the soft tissue injury. Currently, the volumetric three-dimensional (3D) reconstructed CT image is the standard for measuring glenoid bone loss and the glenoid index. However, it has the disadvantage of exposing the patient to radiation and additional expenses. This study aims to compare the values of the glenoid index using MRI and CT.MethodThe present study was a two-year cross-sectional study of patients with shoulder pain, trauma, and dislocation in a tertiary hospital in Karnataka. The sagittal proton density (PD) section of the glenoid and enface 3D reconstructed images of the scapula were used to calculate glenoid bone loss and the glenoid index. The baseline data were analyzed using descriptive statistics, and the Chi-square test was used to test the association of various complications with selected variables of interest.ResultThe glenoid index calculated in the current study using 3D volumetric CT images and MR sagittal PD images was 0.95±0.01 and 0.95±0.01, respectively. The CT and MRI glenoid bone loss was 5.41±0.65% and 5.38±0.65%, respectively. When compared, the glenoid index and bone loss calculated by MRI and CT revealed a high correlation and significance with a p-value of <0.001.ConclusionsThe study concluded that MRI is a reliable method for glenoid measurement. The sagittal PD sequence combined with an enface glenoid makes it possible to identify osseous defects linked to glenohumeral joint damage and dislocation. The values derived from 3D CT are identical to the glenoid index and bone loss determined using the sagittal PD sequence in MRI.
BIOPRINTED LIVING TISSUE CONSTRUCTS WITH LAYER-SPECIFIC, GROWTH FACTOR-LOADED MICROSPHERES FOR IMPROVED ENTHESIS HEALING OF A ROTATOR CUFF ABSTRACT
Authors: Bai L. , Yin Z. 
Published: November 2024

IntroductionThe healing of rotator cuff injuries poses significant challenges, primarily due to the complexity of recreating the native tendon-to-bone interface, characterized by highly organized structural and compositional gradients. Addressing this, our innovative approach leverages bioprinted living tissue constructs, incorporating layer-specific growth factors (GFs) to facilitate enthesis regeneration. This method aims to guide in situ zonal differentiation of stem cells, closely mirroring the natural enthesis tissue architecture.MethodOur strategy involves the utilization of advanced bioprinting technology to fabricate living tissue constructs. These constructs are meticulously designed with embedded microsphere-based delivery carriers, ensuring the sustained release of tenogenic, chondrogenic, and osteogenic growth factors. This layer-specific release mechanism is tailored to promote the precise differentiation of stem cells across different regions of the construct, aligning with the gradient nature of enthesis tissues.ResultIn vitro studies demonstrated that our layer-specific tissue constructs significantly outperformed basal constructs without GFs, achieving region-specific differentiation of stem cells. More critically, in a rabbit model of rotator cuff tear, these bioprinted living tissue constructs expedited enthesis regeneration. Key outcomes included improved biomechanical properties, enhanced collagen deposition and alignment, and the formation of a gradient fibrocartilage interface with aligned collagen fibrils. After 12 weeks, the constructs achieved an ultimate load failure of 154.3 ± 9.5 N resembling that of native enthesis tissues, marking a notable achievement in tissue engineering.ConclusionOur exploration introduces a viable and innovative strategy for engineering living tissue constructs that exhibit region-specific differentiation capabilities. This approach holds significant promise for the functional repair of gradient enthesis tissues, potentially revolutionizing the treatment of rotator cuff injuries by closely replicating the natural tendon-to-bone interface, thus offering a promising avenue for future clinical applications.
SPATIAL TRANSCRIPTOMICS WORKFLOW ENABLES DISTINCT TISSUE-SPECIFIC MOLECULAR CHARACTERIZATION OF NONUNION AND UNION BONE FRACTURES IN MICE
Authors: Giger N. , Schröder M. , Arens D. , Gens L. , Zeiter S. , Stoddart M. , Wehrle E. 
Published: November 2024

BackgroundThe molecular mechanisms underlying non-union bone fractures largely remain elusive. Recently, spatial transcriptomics approaches for musculoskeletal tissue samples have been developed requiring direct placement of histology sections on barcoded slides. However, Formalin-Fixed-Paraffin-Embedded (FFPE) bone sections have been associated with limited RNA quality and read depth compared to soft tissue. Here, we test spatial transcriptomics workflows based on transcriptomic probe transfer to characterize molecular features discriminating non-union and union bone fractures in mice.MethodHistological sections (n=8) used for spatial transcriptomics (Visium CytAssist FFPE; 10x Genomics, n=4 on glass slides, n=4 on hydrogel-coated slides) were obtained from a fracture healing study in female 20-week-old C57BL/6J mice receiving either a femur osteotomy (0.7mm) or a segmental defect (2.4mm) (license 22/2022, Grisons CH). Sequence alignment and manual segmentation of different tissues (bone, defect region/callus, bone marrow, muscle) were performed using SpaceRanger and LoupeBrowser (10x Genomics). Differential gene expression was performed using DESeq2 (Seurat) followed by Gene-Set-Enrichment-Analysis (GSEA) of Gene Ontology (ClusterProfiler). Group comparison of quality measures was done using a Welch's t-test. Results are given as mean±standard deviation.ResultThe quality measures, mean counts, and genes per spot, were significantly ~10× higher for sections on hydrogel slides (counts: 4700±1796, genes: 2389±1170) compared to glass slides (counts: 463±415, genes: 250±223). In challenging tissues like cortical bone, we reached high counts+genes in comparison to published data.Direct comparison of a non-union and union section showed a total of 432 differentially regulated genes, 538 in the defect region/callus. GSEA revealed differential regulation of pathways involved in muscle organ morphogenesis, cartilage development and endochondral ossification.ConclusionsOptimized spatial transcriptomics workflows based on transcriptomic probe transfer enable for improved read depth in musculoskeletal tissue enabling the characterization of molecular features discriminating non-union and union bone fractures.AcknowledgementsAO Foundation (AOTRAUMA), SNSF (PhD salary)
A SCOPING REVIEW TO INFORM CORE OUTCOME SET DEVELOPMENT: WHAT OUTCOMES HAVE BEEN REPORTED IN LITERATURE ON PATIENTS UNDERGOING LOWER-LIMB LENGTHENING SURGERY, AND HOW HAVE THEY BEEN MEASURED?
Authors: Yalcinkaya A. , Tirta M. , Rathleff M. S. , Iobst C. , Rahbek O. , Kold S. 
Published: November 2024

IntroductionThe heterogeneity of outcomes used in the field of lower limb lengthening surgery (LLLS) affects our ability to synthesize evidence. This hampers robust systematic reviews and treatment recommendations for clinical practice. Ultimately this reduces the impact of research for both patients and healthcare professionals. This scoping review aimed to describe the outcomes and outcome measurement instruments (OMIs) used within the field of LLLS.MethodA systematic literature search of WOS, Scopus, Embase, MEDLINE, and the Cochrane Library identified all studies reporting outcomes in children and adults after LLLS. All outcomes and OMIs were extracted verbatim. An iterative process was used to group outcome terms under standardized outcome headings categorized using the COMET Taxonomy of Outcomes.ResultData saturation was achieved in 2020. A total of 142 studies were included between 2024-2020, reporting 2964 verbatim outcomes with 663 standardized outcome terms collapsed into 119 outcome headings (subdomains). A total of 29 patient-reported and 26 clinician-reported outcome instruments were identified. The most commonly reported outcome was “Lengthening amount”, reported in over 72% of the included studies, while “health-related quality of life” was measured in 16% and all life impact outcomes were reported in 19% of the included studies.ConclusionA large number of peer-reviewed publications are available, demonstrating that significant resources are being devoted to research on LLLS. However, reported outcomes for people with LLLS are heterogeneous, subject to reporting bias, and vary widely in the definitions and measurement tools used to collect them. Outcomes likely to be important to patients, such as quality of life and measures of physical function, have been neglected. This scoping review identifies a need to standardize outcomes and outcome measures reported on patients recovering from lower limb lengthening surgery; this can be addressed by creating a core set of outcomes.
Handwerk – aus Tradition innovativ: Der Mensch im Mittelpunkt der Digitalisierung
Authors: Helms Maximilian , Bosbach Julia , Finster Rebecca , Friesecke Maren , Beuchel Sebastian , Bartelt-Urich Karen , Meub Lukas , Thiem Silke , Umel Audris Pulanco , Jantos Louisa , Berger Hermann , Robra-Bissantz Susanne , Lattemann Christoph 
Published: November 2024

ZusammenfassungIn diesem Artikel werden die besonderen Herausforderungen und Treiber der Handwerksbranche in der digitalen Transformation (DT) dargestellt. In den letzten Jahrzehnten hat sich die DT schrittweise in nahezu allen Branchen etabliert und dabei beispielsweise Beziehungen, Interaktionen, Prozesse und Geschäftsmodelle neu gestaltet. Das Handwerk wird hier keine Ausnahme bilden. Obwohl die DT vielfältige Vorteile bietet, stellt ihre Integration ins Handwerk kleine und mittlere Unternehmen (KMU) vor große Herausforderungen. Fehlendes Verständnis, Unsicherheiten in der Einführung und ein Mangel an Vertrauen in die Sinnhaftigkeit der DT im Handwerk führen zu ihrer sehr langsamen Durchdringung. Damit bleiben Chancen ungenutzt ureigenste Interessen des Handwerks zu bedienen: Dienstleistungen für Kunden zu verbessern und Arbeitsbedingungen für Mitarbeitende gut zu gestalten. Dieser einleitende Artikel stellt den aktuellen Stand der DT im Handwerk vor und zeigt auf, dass im Handwerk trotz oder gerade wegen der Digitalisierung der Mensch im Mittelpunkt steht.
Insights into cultural and compliance challenges in type 2 diabetes care: A qualitative study of Moroccan and Belgian patients in Belgium
Authors: Six Stefaan , Israel David , Bilsen Johan , Kharagjitsing Aan 
Published: November 2024

Aims
To explore factors that may contribute to a possible reduced compliance in patients with type 2 diabetes mellitus (T2DM) with a migrant (i.e. North African) background living in a western society.

Methods
Semi-structured interviews with people with T2DM both of Moroccan and Belgian origin, recruited within the diabetes clinic of the University Hospital Brussel, Belgium. Data was analysed thematically using NVivo.

Results
Participants indicated they were adequately informed about T2DM, however results show a demand for culturally tailored preventive education for Moroccan participants. Both groups generally had good knowledge of a healthy lifestyle and what is expected after diagnosis, but considered maintaining healthy lifestyle and correct medication adherence, intensive. Participants mentioned a wide range of themes that affected their compliance, both positively and negatively. Perceived barriers were social issues, lack of motivation, insufficient support from the environment, stress, forgetfulness, winter conditions and COVID. Culturally shaped views on eating habits, illness, medication use and health were clear barriers in the Moroccan group.

Conclusion
Findings highlight the need for future in depth research into diabetes related knowledge within the Moroccan community living in Belgium (and similar other Western countries) whilst considering differences between generations of migrants, gender and level of education.
Surgical managements for rhegmatogenous retinal detachment: A network meta-analysis of randomized controlled trial
Authors: Yan Xinyu , Xu Meng , Su Fengjun 
Published: November 2024

Background and objective
Rhegmatogenous retinal detachment (RRD) is the most common ophthalmic emergency threatening vision, with an incidence ranging from 6.3 to 17.9 per 100,000 people per year. However, optimal surgical management of RRD remains controversial. This network meta-analysis compared the efficacy and safety of different surgical options in patients with RRD.

Methods
We systematically searched PubMed, Embase, Cochrane Library and Web of science for randomized controlled trials (RCT) from inception to 24th September 2023. Frequentist network meta-analyses with the random-effects model was used to synthesize data. The risk of bias for the included RCTs was evaluated using the Cochrane tool for assessing risk of bias, and the certainty of evidence using the Grading of Recommendations, Assessment, Development, and Evaluation approach. And we performed the network meta-analysis utilizing R 4.1.3 software and Stata 16SE.

Results
A total of 19 RCTs enrolled 2589 eyes were included. With high-to-very low certainty of evidence, compared with pneumatic retinopexy (PR), scleral buckling (SB) (odd ratio (OR) = 0.52, 95% confidence interval (CI) [0.30; 0.91]), pars plana vitrectomy (PPV) (OR = 2.35, 95% CI [1.32; 4.20]), PPV+SB (OR = 2.59, 95% CI [1.32; 5.09]) and PPV combined with phacomulsification (PCV) (OR = 7.72, 95% CI [1.07; 55.87]) were more effect in improving primary reattachment rate; for postoperative 6-month vision, SB was superior to PPV+SB (mean difference (MD) = 0.14, 95% CI [0.01; 0.27]). When compared with SB, PPV (OR = 5.27, 95% CI [3.13; 8.86]) and PPV+SB (OR = 10.12, 95% CI [4.31; 23.77]) shows a higher incidence of postoperative cataract progression. Compared to PR, the same is true for PPV (OR = 7.51, 95% CI [3.33; 16.91]) and PPV+SB (OR = 14.43, 95% CI [4.97; 41.93]).

Conclusions
PR appears to be associated with a lower rate of primary reattachment rate and postoperative cataract progression. In view of the small sample sizes of the included studies and the low certainty of evidence, these findings must be interpreted with caution. A large number of high-quality trials should be conducted to verify the effects of different surgical techniques in the future.
Platinum retention in plasma, urine, and normal colonic mucosa in cisplatin-treated testicular cancer survivors
Authors: Breekveldt Emilie C. H. , Ykema Berbel L. M. , Huitema Alwin D. R. , Gietema Jourik A. , Beijnen Jos H. , Snaebjornsson Petur , Schaapveld Michael , van Leeuwen Flora E. , Rosing Hilde , van Leerdam Monique E. ,   on behalf of the CATCHER study working group
Published: November 2024

Testicular cancer survivors (TCS) treated with platinum-based chemotherapy have increased cancer risk. Platinum retention in healthy tissue may contribute to carcinogenesis. We assessed total platinum concentrations in plasma, urine, and normal colonic mucosa samples in TCS treated with cisplatin. From the total TCS treated with ≥3 cycles cisplatin who participated in a colonoscopy-screening study in four Dutch hospitals (n = 154), plasma (n = 131) and urine (n = 115) samples were collected. During colonoscopy, 60 biopsies of normal colonic mucosa (two samples each per 30 randomly selected patients undergoing colonoscopy) were obtained. Samples were analyzed for total platinum concentrations using inductively coupled plasma mass spectrometry and compared with controls (plasma: 10, urine: 3, normal colonic mucosa: 9). The median age at colonoscopy was 50 years (interquartile range (IQR): 43–57) and the median time since treatment was 20 years (IQR:16–26). Median platinum concentrations in plasma (38 pg/mL; IQR: 24–61 pg/mL) and urine (376 pg/mL; IQR: 208–698 pg/mL) remained elevated in TCS up to 40 years post-treatment and were higher than in controls (all controls were below limits of detection [plasma: 25 pg/mL, urine: 6 pg/mL]). The median platinum concentration in normal colonic mucosa was 0.58 pg/mg (IQR: 0.33–1.59 pg/mg) in the transverse and 0.51 pg/mg (IQR:0.26–1.25 pg/mg) in the descending colon. Cisplatin treatment is associated with long-term retention of platinum in various patient sample types. This might increase cancer risk by causing somatic mutations, potentially explaining the elevated risk of second malignant neoplasms in TCS. The long-term effects of platinum retention should be monitored to understand carcinogenesis and to provide guidelines for early second cancer detection.
Trial registration: ClinicalTrials.Gov: NCT04180033.
Tumor Seeding With Needle Biopsy of Hepatocellular Carcinoma: A Systematic Review
Authors: Nie Chunpeng , Vaska Marcus , Wong Jason K. , Bathe Oliver F. , Przybojewski Stefan , Burak Kelly W. , Tang Patricia A. , Congly Stephen E. 
Published: November 2024

INTRODUCTION:
Biopsy of hepatocellular carcinoma (HCC) may help with selecting appropriate chemotherapy with inconclusive imaging; concern about potential seeding may limit its use.

METHODS:
A systematic review was conducted to assess the risk of tumor seeding with biopsy of HCC excluding nonliver cancers or seeding after interventions.

RESULTS:
A total of 2,339 unique abstracts were identified; 37 studies were included in the final analysis. The rate of tumor seeding was 0.62% (range 0%–7.77%) in 13,959 biopsies performed. The average reported median lengths of follow-up was 35.8 months (range 10.5–60 months).

DISCUSSION:
Overall, the risk of tumor seeding with biopsy of HCC is low.
La integración del mercado bursátil latinoamericano: Una revisión sistemática de la literatura
Authors: Cardona Montoya Juan Camilo 
Published: November 2024

Este estudio tiene por objetivo caracterizar las principales temáticas de investigación que se han abordado en torno al Mercado Integrado Latinoamericano(MILA) y, a partir de esto, proponer futuras rutas de estudio. Para ello, fueron revisados 85 artículos relacionados con este campo, publicados entre 2008 y 2022 en revistas indexadas en Scopus, WOS y Google Académico. Los resultados obtenidos sugieren que la investigación sobre el MILA se centró en varios atributos de los mercados financieros y de los reportes corporativos tras el acuerdo de integración, los cuales, junto a los estudios exploratorios sobre la eficiencia transaccional de la plataforma, se seguirán fortaleciendo a partir de una eventual incorporación de nuevos miembros a este mercado y de la fusión de las bolsas de valores de Chile, Colombia y Perú para dar origen al Nuam Exchange.
Christian Knorr von Rosenroth’s Translation of a Lurianic Dissertation:

Liber Druschim, or the

Dissertation on Two Inquiries of the Kabbalists
Authors: Rivera Lusdemar Jacquez 
Published: November 2024

Abstract
The present text analyzes two Hebrew copies of a Lurianic dissertation used by Christian Knorr von Rosenroth for the Latin translation printed in 1677 in Kabbala denudata as Tractatus I. Liber Druschim. This article first identifies the Hebrew source for Knorr von Rosenroth’s translation and offers new insights into his style and method of translation, contributing to a better understanding of Rosenroth’s approach to kabbalistic tradition. Secondly, this article contributes to the history of the transmission of Lurianic manuscripts and posits Sulzbach as an important center for the circulation and translation of kabbalistic knowledge.
Interpretation, Rewriting, and Editing: The Copyists of
Sefer ha-Temunah
in Ashkenaz
Authors: Goldschmidt Roee 
Published: November 2024

Abstract
The article discusses Sefer ha-Temunah, a key kabbalistic text on the twenty-two letters of the Torah, and emphasizes the need for philological research to address its textual challenges and variations. The article explores the editing practices of early modern Ashkenazi kabbalistic copyists and the influence of Koretz printing house editors on the text’s history and reception. Finally, this article underscores the dynamic nature of kabbalistic literatures and its continuous evolution through scholarly and editorial efforts.