bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ocrelizumab – a monoclonal antibody – in the treatment of adult patients with multiple sclerosis: a systematic review
Authors: Klabukova D. L. , Holownia-Voloskova M. E. , Davydovskaya M. V. , Ermolaeva T. N. , Polyakova K. I. , Fisun A. G. , Kokushkin K. A. 
Published: November 2018

Aim: To analyze the efficacy, safety and pharmacoeconomic aspects of using ocrelizumab in adult patients with relapsing/remitting multiple sclerosis (R/R MS).Materials and Methods. We used the commonly accepted PICo(S) questionnaire with the following specifics: the population – patients with R/R MS; the intervention – ocrelizumab; the comparators – all disease-modifying treatments for MS; the outcomes – the annualized relapse rate, confirmed disability progression, MRI results, quality-adjusted years of survival (QALYs), adverse events, and other clinical outcomes. The search for the relevant information was conducted in 2018 by using the embase, PubMed, Cochrane and eLibrary.ru databases and the «ocrelizumab» AND «multiple sclerosis» keywords. The levels of evidence and conclusiveness of the cited studies were also assessed.Results. Treatments with ocrelizumab resulted in a lower rate of disease progression as compared with interferon β -1a. As evidenced by a randomized clinical trial, the annualized relapse rate estimated after 96 weeks was lower with ocrelizumab than that with interferon β-1a (0.16 vs. 0.29, 47% decrease, p<0.001). For most secondary end points, patients on ocrelizumab showed better outcomes than those on interferon β-1a. In the ocrelizumab group, the most common adverse events were caused by reactions to the drug infusion, nasopharyngitis, upper respiratory and urinary tract infections, and headaches. No cases of progressive multifocal leukoencephalopathy have been reported so far. ocrelizumab is more clinically effective than the first-line disease-modifying therapies; this conclusion also refers to patients with the aggressive (highly active) form of MS. ocrelizumab showed the efficacy similar to the second-line disease-modifying therapies, but it had a more favorable safety profile. The pharmacoeconomic indices showed that using ocrelizumab had a positive impact on the budget in the long-term perspective.Conclusions. ocrelizumab can be considered as the main treatment alternative for patients with highly active MS and patients with a high risk of progressive multifocal leukoencephalopathy. However, an additional assessment of the risk caused by rare adverse events is needed.
ESTRESSE ENTRE ESTUDANTES DE GRADUAÇÃO EM ENFERMAGEM: ASSOCIAÇÃO DE CARACTERÍSTICAS SOCIODEMOGRÁFICAS E ACADÊMICAS
Authors: Costa Christefany Régia Braz , Maynart Willams Henrique da Costa , Oliveira Layze Braz de , Albuquerque Maria Cícera dos Santos de , Correia Divanise Suruagy 
Published: November 2018

Verificar a prevalência do estresse entre estudantes de graduação em enfermagem e sua associação com as características sociodemográficas e acadêmicas. Estudo tranversal, de abordagem quantitativa, realizado com 236 estudantes de enfermagem de uma instituição de ensino superior pública, no período de setembro de 2013 a janeiro de 2014. Utilizou-se instrumento contendo variáveis sociodemográficas, acadêmicas e o Inventário de Sintomas de Estresse para Adultos de LIPP. Foi realizado teste Qui-quadrado, adotando p
Neuropsychiatric symptoms in dementia
Authors: Manera Valeria , Brousse Julie , Foulon Pierre , Deudon Audrey , Leone Elsa , David Renaud , Robert Philippe 
Published: November 2018

Neuropsychiatric symptoms (NPS) are very common in people with dementia-related disorders, and are responsible for a large share of the suffering of patients and caregivers. Current evidence suggests that non-pharmacological treatments are promising solutions to NPS. However, a critical factor in the treatment success is represented by the involvement of professional and family caregivers. Here we briefly present “No panic in the nursing home”, an educational “serious game” designed for healthcare professionals working in nursing homes. Based on an educational program previously designed by our group, “No Panic in the Nursing Home” teaches professional caregivers how to deal with NPS of dementia. The player takes the role of a nursing home nurse, and is confronted with practical situations in which he/she needs to decide how to behave. Results collected in three nursing homes suggest that the game is considered as very interesting by nursing home healthcare professionals, even by persons with no previous experience with videogames.
An Investigation on Entrepreneurial Competencies of Creative Industry in Bandung, Indonesia
Authors: Foster Bob 
Published: November 2018

The previous research reveals the significant influence of entrepreneurial competencies on entrepreneur's performance. This finding indicates that there should be further exploration of entrepreneurial competencies. This study aims to determine the entrepreneurial competencies regarding the process. Moreover, this research uses the quantitative approach with non-parametric structural equation modeling. The population of this study is the creative industry in Bandung. The research samples are 119 entrepreneurs in the creative industry. This study finds that some competencies are the components that create the entrepreneurial competencies of creative industries entrepreneurs in Bandung. The components are Relationship Competencies, Opportunity Competencies, Strategic Competencies, Human Competencies and Personal Strength Competencies. The research implication recommends increasing the value of the creator's components of entrepreneurial competencies. Hence, they have implications on the performance of MSMEs in the sector of creative industry in Bandung.
Diagnosis and treatment of chronic cerebral ischemia (clinical discussion)
Authors: Zakharov V. V. , Vakhnina N. V. 
Published: November 2018

The article presents a clinical case of diagnosis and treatment of the initial presentations of chronic cerebral ischemia (CCI) in the form of cognitive impairments in a middle-aged patient. The authors describe such features of cognitive impairments (CI) as the predominance of «subcortical» symptoms (bradyfrenia, fluctuation), which is typical for CCI. The article presents modern approaches to the diagnosis of CCI, according to which it is necessary to focus on the assessment of higher brain functions, while the significance of «focal microsymptoms» is not large. The article discusses the treatment issues of CCI, which should first include the achievement of the maximum possible control over the underlying vascular disease. It also provides the results of recent studies of the effectiveness of pathogenetic neurometabolic therapy for vascular CIs.
A CFD modeling procedure to assess the effect of wind in settling tanks
Authors: Gkesouli A. , Stamou A. 
Published: November 2018

Abstract
We propose a systematic procedure that combines computational fluid dynamics (CFD) modeling and experimental work to answer two research questions that are usually posed by researchers and managers of water treatment plants: ‘Is the effect of wind on settling tanks important?’ and ‘How can we determine this effect in our settling tanks?’ We apply this procedure in the water treatment plant of Aharnes, Athens to derive the following conclusions. (1) The effect of wind increases with increasing co-current wind velocity, increasing settling velocity and decreasing flow rate. (2) In windy steady-state flow conditions, the degree of complexity and three-dimensionality of the flow field that is observed in calm conditions is reduced and the removal efficiency decreases from 85.1 in calm conditions to 82.0%. Predicted efficiencies for constant and variable inlet solids' concentrations compare favorably with measurements. (3) In windy, transient flow conditions, field data show that the effect of wind on the tank's efficiency can be very pronounced and within the first half hour of the windy period the efficiency decreases to approximately 55%; the present model does not capture this effect, because it cannot simulate the sludge layer and the subsequent re-suspension of the settled solids.
Water resources data, models and decisions: international expert opinion on knowledge management for an uncertain but resilient future
Authors: Ward Sarah , Scott Borden D. , Kabo-bah Amos , Fatawu Abdul Nasirudeen , Mwinkom Xavier Francis 
Published: November 2018

Abstract
Assessing the resilience of water resources systems requires knowledge of properties and performance, which depends on data availability and use within models and decision making. Connections between data, models and decision making are crucial to plan for uncertainty and invest in interventions. To explore international perceptions of these connections, we conducted a three-round Delphi survey with an expert panel (see Supplementary material, available with the online version of this paper). Consensus and divergence existed within and between countries on ability to manage data, modelling and decision making, with the most consensus seen on use of hydrometric databases. There was a wide range of models and tools utilised by participants and a shift occurred between first and second rounds to a preference for trying new modelling. There was consensus between and within all countries that every data type was important. River flow data consistently scored highest. Access to data and models primarily impacted evaluating future capacity, planning under uncertainty, policy implementation and conflict resolution. The panel called for reviewing existing and developing new policy, collaborative research and available funding all focusing on water resources data-model-decision integration. Findings offer a strategic view on knowledge management regarding connections between data, models and decision making through identification of consensus areas for future focus and dissensus areas for reprioritisation.
Heritage Street and Contemporary Use of Old Buildings in Johor
Authors: Wan Ismail Wan Hashimah 
Published: November 2018

This paper concerns the use of the buildings along a heritage street in Johor Bahru city centre in Malaysia. The fabrics of Johor Bahru city are in the phase of changing, similar to the other cities in the world. Parts of the city were already torn down and replaced by new buildings to meet the demands of the modern society. Some sections of the city were accepted as heritage area by the local authority. This includes a street known as Tan Hiok Nee Street. Both sides of the street are lined partly with rows of shop houses built in the early 20th century. A preliminary study on the street indicated that it was not popular with the general public during the daytime. It is often emphasized by scholars that the current and future uses of old buildings are crucial to their survival. The usefulness of the existing buildings along the street was thus questionable. The research was then conducted to examine the current situation of the street, especially in the use and condition of the buildings. The intention was also to probe into the reasons why the street was not lively. The data was collected from site observation, literature review and interviews with the tenants, owners as well as visitors. The analysis was based on these data from which the conclusions were drawn. It was found that part of the street was rather quiet with some of the shops hardly survived to meet ends. Some of the buildings were not in use and their condition revealed poor maintenance. The external area was already upgraded by the local authority. However, the condition of the area showed a lack of maintenance. The other reasons include the shifting of the residents, the lack of strong interest for visitors, the lack of strong connectivity to the major nodes and the high rent. It is inevitable that the whole area needs constant supervision. It also suggests that some of the buildings do not meet the current demands of the users. This may result in the removal of the buildings in the near future. Some strategies need to be devised in order to retain the heritage street for the benefit of future generations.
Zonificación edafoclimática para el cultivo de la papaya en Valencia Córdoba - Colombia
Authors: Leon Duran Ricardo , Combatt Castillo Enrique Miguel , Villalba Arteaga José Vicente , Polo Santos Janer Miguel , Valencia Agressoth Robert Smith 
Published: November 2018

En este estudio se evaluaron y clasificaron los recursos climáticos y edáficos de la zona Norte del municipio de Valencia Córdoba, usando geoestadística y sistemas de información geográfica (SIG). En el componente climático se usaron datos de precipitación, temperatura, humedad relativa y radiación solar de cinco estaciones meteorológicas. Para el componente edafológico se realizaron 119 análisis de suelos de dos asociaciones productoras de papaya y plátano de la zona. La cartografía de distribución espacial de las variables se realizo por método de interpolación de la distancia inversa ponderada con el programa ArcMap; se elaboraron mapas de variables espacializadas en una escala 1:250.000. Mediante este procedimiento fueron calculadas áreas delimitadas por isolíneas en las variables de clima y suelo. En la cartografía de áreas con aptitud productiva se usó una escala de cuatro categorías con las variables pH, M.O., textura, P y Al, las cuales fueron A1: Muy óptima, A2: óptima, A3: ligeramente óptima y A4: moderadamente óptima. Como resultado se obtuvieron: zonas muy óptimas (A1), 4,6% equivalentes a aproximadamente a 3.050 ha, ubicadas en la parte norte del área de estudio, zonas óptimas (A2) el 55%, con 36.440,7 ha, ubicadas en el centro del área de estudio, las zonas ligeramente óptimas (A3) el 35,5%, con 23.533,6 ha, ubicadas en la parte suroriental y Zonas moderadamente óptimas (A4) el 4,7%, con 3.156,5 ha, ubicadas en el sector suroccidental de la zona estudiada. Esta clasificación es fundamental en la proyección agropecuaria de la zona y en en los proyectos de ordenamiento territorial.
Plasma Fucosylated Glycans and C-Reactive Protein as Biomarkers of HNF1A-MODY in Young Adult–Onset Nonautoimmune Diabetes
Authors: Juszczak Agata , Pavić Tamara , Vučković Frano , Bennett Amanda J. , Shah Neha , Pape Medvidović Edita , Groves Christopher J. , Šekerija Mario , Chandler Kyla , Burrows Carla , Rojnić Putarek Nataša , Vučić Lovrenčić Marijana , Ćuća Knežević Jadranka , James Tim J. , Gloyn Anna L. , Lauc Gordan , McCarthy Mark I. , Owen Katharine R. , Gornik Olga 
Published: November 2018

OBJECTIVE
Maturity-onset diabetes of the young (MODY) due to variants in HNF1A is the most common type of monogenic diabetes. Frequent misdiagnosis results in missed opportunity to use sulfonylureas as first-line treatment. A nongenetic biomarker could improve selection of subjects for genetic testing and increase diagnosis rates. We previously reported that plasma levels of antennary fucosylated N-glycans and high-sensitivity C-reactive protein (hs-CRP) are reduced in individuals with HNF1A-MODY. In this study, we examined the potential use of N-glycans and hs-CRP in discriminating individuals with damaging HNF1A alleles from those without HNF1A variants in an unselected population of young adults with nonautoimmune diabetes.

RESEARCH DESIGN AND METHODS
We analyzed the plasma N-glycan profile, measured hs-CRP, and sequenced HNF1A in 989 individuals with diabetes diagnosed when younger than age 45, persistent endogenous insulin production, and absence of pancreatic autoimmunity. Systematic assessment of rare HNF1A variants was performed.

RESULTS
We identified 29 individuals harboring 25 rare HNF1A alleles, of which 3 were novel, and 12 (in 16 probands) were considered pathogenic. Antennary fucosylated N-glycans and hs-CRP were able to differentiate subjects with damaging HNF1A alleles from those without rare HNF1A alleles. Glycan GP30 had a receiver operating characteristic curve area under the curve (AUC) of 0.90 (88% sensitivity, 80% specificity, cutoff 0.70%), whereas hs-CRP had an AUC of 0.83 (88% sensitivity, 69% specificity, cutoff 0.81 mg/L).

CONCLUSIONS
Half of rare HNF1A sequence variants do not cause MODY. N-glycan profile and hs-CRP could both be used as tools, alone or as adjuncts to existing pathways, for identifying individuals at high risk of carrying a damaging HNF1A allele.
Improvement in Neuropathy Outcomes With Normalizing HbA1c in Patients With Type 2 Diabetes
Authors: Ishibashi Fukashi , Taniguchi Miki , Kosaka Aiko , Uetake Harumi , Tavakoli Mitra 
Published: November 2018

OBJECTIVE
To investigate the impact of normalizing HbA1c by extensive HbA1c control (EHC) on neuropathy outcome measures (NOMs), nephropathy, and retinopathy in type 2 diabetes.

RESEARCH DESIGN AND METHODS
Detailed clinical and neurological examinations were performed in two cohorts of 38 patients with uncontrolled type 2 diabetes (HbA1c 9.6% [81.4 mmol/mol]) at baseline and after glycemic control (GC) with or without EHC by diet restriction and hypoglycemic agents over 4 years along with 48 control subjects with normal glucose tolerance (NGT) and 34 subjects with impaired glucose tolerance (IGT) only at baseline. EHC patients, control subjects, and subjects with IGT underwent oral glucose tolerance tests. Glycemic variability (GV) was evaluated by SD and coefficient of variation of monthly measured HbA1c levels and casual plasma glucose.

RESULTS
In the EHC cohort, HbA1c levels over 4.3 years and the last 2 years improved to 6.1% (43.2 mmol/mol) and 5.8% (39.9 mmol/mol) with 7.3 kg body wt reduction, and 50% and 28.9% of patients returned to IGT and NGT, respectively, at end point. Baseline neurophysiological and corneal nerve fiber (CNF) measures were impaired in patients. Normalized HbA1c with EHC improved neurophysiological and CNF measures to be similar for those for IGT, while GC without EHC (mean HbA1c level 7.0% [53.5 mmol/mol]) improved only vibration perception. The mean normalized HbA1c levels by EHC determined NOM improvements. The high GV and baseline HbA1c levels compromised NOMs. Albumin excretion rate significantly decreased, while retinopathy severity and frequency insignificantly worsened on EHC.

CONCLUSIONS
Normalizing HbA1c in type 2 diabetes of short duration improves microvascular complications including neuropathy and nephropathy more effectively than standard GC but not retinopathy.
DE LA GENESE DU SIGNE DU SENS ET DU CONCEPT, PENSEE VERBALE ET PENSEE LOGIQUE
Authors: GENESTE Philippe 
Published: November 2018

About the genesis of the sign. About sense and concept, verbal thought and logical thought. The psychogenesis of language show us that the operations of discourse are not logical opérations. We need a constructivist theory of language if we want to understand the mecanisms of this acquisition. The author weaves together the Jean Piaget’s genetic psychology and genetic epistemology with Gustave Guillaume’s psychomecanics of language. He demonstrates the singularity of the language not reducible to logico-mathematics pattern. Here is the opposition between « operative » and « operatoire », an opposition already studies by André Jacob.
Rezumat. Despre geneza semnului. Despre sens și concept, gândire verbală și gândire logică. Psihogeneza limbajului ne arată că operațiunile discursului nu sunt operații logice. Avem nevoie de o teorie constructivistă a limbajului dacă vrem să înțelegem mecanismele acestei achiziții. Autorul combină contribuția psihologiei genetice și a epistemologiei genetice, datorate lui Jean Piaget, cu psihomecanica limbajului propusă de Gustave Guillaume. El demonstrează că există o singularitate a limbii care nu poate fi redusă la modelul logico-matematic. Aici se regăsește opoziția dintre "operativ" și "operator", aprofundată deja de André Jacob.
Cuvinte cheie: achiziție, acomodare, asimilare, constructivism, discurs, limbă, logic, operativ, operație, “operator”, psichomecanica limbajului, schemă, semn, stadiu de dezvoltare, simbol.
NOUVELLES PERSPECTIVES
Authors: SÉRO-GUILLAUME Philipp 
Published: November 2018

New Perspectives. Language representation and image representation are linked. Although there is no historical coincidence, it is possible to theorise that there is a coincidence between the structural genesis of languages (Gustave Guillaume) and the shapes of equilibration of genetic epistemology (Jean Piaget).
Rezumat. Noi perspective. Reprezentarea prin limbă și reprezentarea prin imagine sunt legate între ele. Deși nu există o coincidență istorică, este posibil să se teoretizeze că există o coincidență între geneza structurală a limbilor (Gustave Guillaume) și formele de echilibrare a epistemologiei genetice (Jean Piaget).
Cuvinte-cheie: structură, arie, echilibrare, perspectivă, incidență, spațiu.
Rate of return to agility competition for dogs with cranial cruciate ligament tears treated with tibial plateau leveling osteotomy
Authors: Heidorn Shannon N. , Canapp Sherman O. , Zink Christine M. , Leasure Christopher S. , Carr Brittany J. 
Published: November 2018

Abstract
OBJECTIVE To determine rate of and factors associated with return to agility competition for dogs with cranial cruciate ligament (CrCL) rupture treated with tibial plateau leveling osteotomy (TPLO).
DESIGN Retrospective case series with nested case-control study.
ANIMALS 31 dogs involved in agility competition with CrCL tears treated by TPLO at a private veterinary clinic from 2007 through 2013.
PROCEDURES Medical records were reviewed to collect information on dog signalment, lesion characteristics, and surgical data. Owners completed a survey regarding whether and when their dog returned to agility competition after TPLO and, if so, how the dog performed. Performance data before and after TPLO were compared.
RESULTS 20 of 31 (65%) dogs returned to agility competition after TPLO, 16 (80%) of which returned within 9 months after TPLO. The mean convalescent period for returning dogs was 7.5 months (range, 3 to 12 months). No dog that returned to competition sustained an injury to the affected limb during the follow-up period. No significant difference was identified between dogs that returned or did not return to agility competition regarding severity of osteoarthritis or proportions with meniscal injury or partial (vs complete) CrCL tears.
CONCLUSIONS AND CLINICAL RELEVANCE These data suggested that the prognosis for returning to agility competition was good for dogs undergoing TPLO. None of the evaluated lesion characteristics were associated with return to competition. Rate of return to competition and duration of the convalescent period may be useful outcome variables for future investigations involving orthopedic procedures in dogs.
Program Pascasarjana Institut Seni Indonesia Yogyakarta
Authors: Amala Marventyo 
Published: November 2018

Fotografi adalah sebuah seni melihat. Dengan kata lain, fotografi mengajarkan
kepada kita cara yang unik dalam melihat dunia dan sekaligus memberikan
penyadaran baru akan segala keindahan yang ada di sekitar kita. Fotografi juga
mengajarkan kepada kita untuk melihat lebih dalam, menggali makna, dan
memahaminya sehingga menumbuhkan rasa cinta yang dapat menciptakan inspirasi.
Lalu dari situlah berbagai karya fotografi dari fotografer-fotografer dunia
bermunculan. Salah satunya adalah Andreas Gursky, seorang seniman foto kelahiran
Jerman, dengan karyanya yang berjudul Rhein II. Karya tersebut sangatlah
berlawanan dengan apa yang dilihat banyak orang. Kedalaman makna serta
kehadirannya mampu membuka mata akan suatu kehadiran fiksi sebuah keberadaaan
nyata.

Photography is an art of seeing. In other words, photography taught us a unique
way of seeing the world and provide a new awareness of the beauty in all around us.
Photography also teaches us to look deeper, dig meaning, and understand that
foster a sense of love that can create inspiration. And that's where a variety of
photographic works of world photographers popping. One of them is Andreas
Gursky, a German-born artist photo, with his work entitled Rhein II. The work
contrasts sharply with what is seen by many people. The depth of meaning and its
presence will be able to open the eyes of a fictional presence of a real existence.