bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensitivity and Specificity of the SelfAdministered HPV Testing in Detecting Precancerous Conditions of the Cervix and Cervical Cancer
Authors: Nyngsi Erny M , Rauf Syahrul , Moeljono Eddy 
Published: October 2018

Objective: To determine the sensitivity and specificity of selfadministered Human Papilloma virus (HPV) test in detecting pre-cancerous lesions and high degree cervical cancer.
Methods: A case control study design was used in this study. This study was conducted at Dr. Wahidin Sudirohusodo Hospital and its affiliate hospitals during the period of October 2014 to May 2015. Measurement data using HPV self test grant from the Dutch School Netherlands, Evalyn Brush. Collecting data used questionnaires before and after doing HPV self test. Laboratory tests are carried out in Kalbe Genomic using HPV Genotyping capable detect 35 types of the HPV virus.
Results: A total of 101 subjects were involved in this study. The subjects were divided into two groups, the case and the controls (n = 50/51). Level of sensitivity and specificity were obtained for HPV self test (56% vs 98%). The level of acceptance of new tests by 62.37% (63 out of 101 respondents) of them admitted that the new test is simple / easy enough to do. The acuracy rate of diagnostic test of this examination is 79%.
Conclusion: Self-administered HPV test could be used as an alternative or primary screening for cervical cancer.
[Indones J Obstet Gynecol 2017; 5-3: 173-179]
Keywords: HPV, self, specificity, the sensitivity
A Case of BeckwithWiedemann Syndrome with Polyhydramnios
Authors: Yusrawati Yusrawati , Muhatiah Reno 
Published: October 2018

Objective: To report a rare case of Beckwith-Wiedemann Syndrome with polyhydramnios.
Methods: Reporting a case of Beckwith-Wiedemann syndrome with polyhydramnios.
Results: Case of Mrs. Y, 27 years old woman, G2P1A0L1 preterm pregnancy (30-31 weeks) with polyhidramnios. From ultrasound found renomegaly, bilateral hyperechogenic polycystic kidney, and the karyotype result was 46,XX. Caesarean section was performed due to fetal distress. A female baby was born by caesarean section with birth weight of 1300 grams, 37 centimeters of body length, and APGAR score of 6/8. The congenital anomalies found were hepatomegaly, renomegaly, bilateral hyperechogenic renal polycystic, low set ears. The baby was died in NICU on day care 5th, with suspected of sepsis.
Conclusion: Prenatal diagnosis of Beckwith-Wiedemann syndrome on fetus with polyhydramnios.
[Indones J Obstet Gynecol 2017; 5-3: 185-188]
Keywords: amniocentesis, beckwith-wiedemann syndrome, polyhydramnios, prenatal diagnostic, USG
The Risk of Ovarian Malignancy Algorithm (ROMA) as a Predictor of Ovarian Tumor Malignancy
Authors: Forbes Darlin , Sastradinata Irawan , Agustiansyah Patiyus , Theodorus Theodorus 
Published: October 2018

Object: To assess the diagnostic value of Risk of Ovarian Malignancy Algorithm (ROMA) in predicting ovarian malignancy.
Methods: Diagnostic test was performed at dr. Mohammad Hoesin Hospital Palembang during June 2016 to November 2016. Data were analized with SPSS version 21.0 and Med-calc statistic.
Results: A total of 57 subjects were recruited in this study. Subjects were divided into two groups: the premenopausal and postmenopausal group. Analysis with ROC curve was performed, the ROMA optimal cut-off of ROMA was 23.7% and 48.15% in the premenopausal and the post-menopausal group, respectively. With the optimal cut-off, the sensitivity was 79.41% and specivicity was 75%, positive predictive value wa 73.07% and negative predictive value 83.77% with accuracy 76.92% in diagnosing ovarian malignancy. Compared to RMI-3, the sensitivity was 65.5% and specivicity was 85.7% with accuracy 75.44%.
Conclusion: ROMA is not a reliable diagnostic tools of ovarian malignancy.
Keywords: CA125, HE4, ovarian cancer, risk of ovarian malignancyalgorithm/ ROMA, risk of ovarian malignancy index/RMI
Effectiveness of Oral Probiotics (Lactobacillus Rhamnosus Gr1 and Lactobacillus Reuteri RC14) as Adjuvant Therapy in Reproductive Aged Women with Vaginal Discharge
Authors: Indarti Junita , Budidarmo Utomo 
Published: October 2018

Objective: To investigate the efficacy of oral probiotics andprove the high proportion of cure and satisfaction levels ofpost-treatment patients with a combination of antimicrobialprobioticoral Lactobacillus rhamnosus GR-1 and Lactobacillusreuteri RC-14 compared to a combination of antimicrobialplaceboin the treatment of reproductive aged patients withvaginal discharge in the outpatient obstetrics and gynecologicclinic in Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesiaand Arifin Achmad Regional Hospital Pekanbaru, Riau,Indonesia.

Methods: This was a randomized, double-blind, placebo-controlledtrial involving 50 subjects consisting of reproductive aged women.Data were collected using syndromic approach, probiotics weregiven as an adjuvant for standard antimicrobial therapy versusplacebo as control, response was recorded 4 weeks later, for cureproportion and satisfaction level. Statistical analysis was performedto assess the variables. Interim analysis with conditional powerassesment and futility testing were performed at midway due toinsufficient sample size. Research was approved by Ethics Commiteefor Health Researches Faculty of Medicine University of IndonesiaDr. Cipto Mangunkusumo Hospital in March 2016.

Results: A total of 50 subjects participated in this study andanalyzed (25 subjects in each group), cure proportion 56% (14) ofthe treatment and 60% (15) on the control group, with relativerisk of 1.1, Chi-square test p value 0.77 (95% CI; 0.57 to 2 , 11).High satisfaction level (score 67) was higher in the placebo(52.6%, 10 subjects) compared to probiotic group (47.4%,9 subjects), p value 0.65 (0.05). Conditional power and futilitytesting curve, revealed Z = -0.2865, conditional power 0.11 to0.13, and futility index of 0.87 to 0.88, equals to low possibility ofstatistical significance with full sample size (84).

Conclusion: There was no clinical and statistical difference in theproportion of cure rate and the level of satisfaction in patients ofprobiotics vs placebo groups after treatment for 4 weeks. Theinitial hypothesis of higher proportion of the cure rate in thetreatment group still cannot be excluded, due to insufficientsamples.

Keywords: bacterial vaginosis, lactobacillus reuteri RC-14, lactobacillusrhamnosus GR-1, randomized double blind controlled trial,trichomoniasis, vaginal discharge, vulvovaginal candidiasis
Diagnostic and prognostic value of additional SPECT/CT in sentinel lymph node mapping in breast cancer patients
Authors: Pernthaler Birgit , Schwarz Thomas , Bjelic-Radisic Vesna , Kerschbaumer Stefan , Aigner Reingard M , Stanzel Susanne 
Published: October 2018

SummaryThe aim of the study was to demonstrate the diagnostic and prognostic value of SPECT/CT in sentinel lymph node mapping (SLNM) in patients with invasive breast cancer. Methods: 114 patients with invasive breast cancer with clinically negative lymph nodes were included in this retrospective study as they were referred for SLNM with 99mTc-nanocolloid. Planar image acquisition was accomplished in a one-day or two-day protocol depending on the schedule of the surgical procedure. Low dose SPECT/CT was performed after the planar images. The sentinel lymph node biopsy (SLNB) was considered false negative if a primary recurrence developed within 12 months after SLNB in the axilla from which a tumor-free SLN had been removed. Results: Between December 2009 and December 2011, 114 patients (pts.) underwent SLNM with additional SPECT/CT. Planar imaging identified in 109 pts. 139 SLNs, which were tumor-positive in 42 nodes (n = 41 pts.). SPECT/CT identified in 81 pts. 151 additional SLNs, of which 19 were tumor-positive and led to therapy change (axillary lymph node dissection) in 11 pts. (9.6 %). Of overall 61 tumor-positive SLNs (n = 52 pts.) SPECT/CT detected all, whereas planar imaging detected only 42 of 61 (P < 0.0001). No patient had lymph node metastasis within 12 months after SLNB in the axilla from which a tumor-free SLN had been removed resulting in a false-negative rate of 0 %. The local relapse rate was 1.8 % leading to a 4-year disease-free survival rate of 90 %. Conclusion: Among patients with breast cancer, the use of SPECT/CT-aided SLNM correlated due to a better anatomical localization and identification of planar not visible SLNs with a higher detection rate of SLNs. This led to therapeutic consequences and an excellent false-negative and 4-year disease-free survival rate.
Analytical Model for the Dynamical Motion of the Bulges of Two Interacting Galaxies
Authors: López Elkin L. , López Gustavo V. , Kemp Simon N. 
Published: October 2018

Abstract
Two mathematical models of three bodies of variable masses are used to obtain a qualitative description of two interacting galaxies with mass exchange and mass loss. The reference system is centered on the largest body (the most massive galaxy), and the other two bodies are allowed to move around this one under the laws of gravity. The third body, which simulated the mass lost by the second galaxy in the form of a tail, increases its mass due to the mass lost by the second body and follows its trajectory. We are interested in knowing the time evolution of the separation of the two bulges of the interacting galaxies, and the parameters for the analytical models are obtained by running simulations with the GADGET-2 N-body code. The resulting behavior of this distance in our mathematical models is qualitatively in good agreement with that obtained by this code.
A Deep Search for Planets in the Inner 15 au around Vega
Authors: Meshkat Tiffany , Nilsson Ricky , Aguilar Jonathan , Vasisht Gautam , Oppenheimer Rebecca , Su Kate Y. L. , Cady Eric , Lockhart Thomas , Matthews Christopher , Dekany Richard , Leisenring Jarron , Ygouf Marie , Mawet Dimitri , Pueyo Laurent , Beichman Charles 
Published: October 2018

Abstract
We present the results of a deep high-contrast imaging search for planets around Vega. Vega is an ideal target for high-contrast imaging because it is bright, nearby, and young with a face-on two-belt debris disk that may be shaped by unseen planets. We obtained J- and H-band data on Vega with the coronagraphic integral-field spectrograph Project 1640 (P1640) at Palomar Observatory. Two nights of data were obtained in 2016, in poor seeing conditions, and two additional nights in more favorable conditions in 2017. In total, we obtained 5.5 hours of integration time on Vega in moderate to good seeing conditions (<1.″5). We did not detect any low-mass companions in this system. Our data present the most sensitive contrast limits around Vega at very small separations (2–15 au) thus far, allowing us to place new constraints on the companions that may be sculpting the Vega system. In addition to new constraints, as the deepest data obtained with P1640, these observations form the final legacy of the now decommissioned instrument.
Disentangling Blended K2 Photometry: Determining the Planetary Host Star
Authors: Payne Alan N. , Ciardi David R. , Kane Stephen R. , Carter Brad 
Published: October 2018

Abstract
The presence of companion stars, whether bound or unbound, make correct identification of the planetary hosting star difficult when a planet has been detected through a photometrically blended transiting event. We present an approach that uses a combination of light curve analysis and stellar modeling to disentangle eight K2 photometrically blended binary systems that have either a confirmed or suspected planet to identify the probable host star. The key to our approach is the use of the mean stellar density, calculated using the transit geometry, as a discriminator. The approach is strongly dependent on the difference in magnitude between the stars and the observed transit depth, which is corrected by the flux ratio between the two stars. While our approach does not lead to a definitive result for all systems, we were able to determine the following for the eight systems in this case study: there are two systems where the primary was highly likely to be the planet-hosting star (>90% likelihood); three systems where the primary was likely to be the hosting star (>55% likelihood); one system where the secondary was likely to be the planet-hosting star (>55% likelihood); and two systems where we were uncertain which star was the planet-hosting star (≈50% likelihood to be either the primary or the secondary). Two systems, denoted by their EPIC number, EPIC 201546283 and EPIC 201862715, had confirmed planets, K2-27b and K2-94b, respectively, with radii of 4.0 ± 0.1 and 16.4 ± 2.9 R⊕, respectively.
Hints of Multiple Populations in Intermediate-age Clusters of the Small Magellanic Cloud
Authors: Piatti Andrés E. 
Published: October 2018

Abstract
We report on the magnitude of the intrinsic [Fe/H] spread in the Small Magellanic Cloud (SMC) intermediate-age massive clusters NGC 339, 361, Lindsay 1 and 113, respectively. In order to measure the cluster metallicity dispersions, we used accurate Strömgren photometry of carefully selected cluster red giant branch (RGB) stars. We determined the Fe-abundance spreads by employing a maximum likelihood approach. The spreads obtained using the more accurate photometry of the brighter RGB stars resulted to be marginal (∼0.05 ± 0.03 dex) for NGC 339 and NGC 361, while for Lindsay 1 and Lindsay 113, we obtained metallicity spreads of 0.00 ± 0.04 dex. From these results, we speculate that NGC 361 is added to the group of four SMC clusters with observational evidence of multiple populations (MPs). Furthermore, in the context of the present debate about the existence of Fe-abundance inhomogeneities among old clusters with MPs, these outcomes place new constrains on recent theoretical speculations for making this phenomenon visible.
The First Orbital Period of a Very Bright and Fast Nova in M31: M31N 2013-01b
Authors: Marelli Martino , De Martino Domitilla , Mereghetti Sandro , De Luca Andrea , Salvaterra Ruben , Sidoli Lara , Israel Gianluca , Rodriguez Guillermo 
Published: October 2018

Abstract
We present the first X-ray and UV/optical observations of a very bright and fast nova in the disk of M31, M31N 2013-01b. The nova reached a peak magnitude R ∼ 15 mag and decayed by 2 mag in only 3 days, making it one of the brightest and fastest novae ever detected in Andromeda. From archival multiband data we have been able to trace its fast evolution down to U > 21 mag in less than two weeks and to uncover for the first time the super-soft X-ray phase, whose onset occurred 10–30 days from the optical maximum. The X-ray spectrum is consistent with a blackbody with a temperature of ∼50 eV and emitting radius of ∼4 × 109 cm, larger than a white dwarf (WD) radius, indicating an expanded region. Its peak X-ray luminosity, 3.5 × 1037 erg s−1, places M31N 2013-01b among the most luminous novae in M31. We also unambiguously detect a short 1.28 ± 0.02 hr X-ray periodicity that we ascribe to the binary orbital period, possibly due to partial eclipses. This makes M31N 2013-01b the first nova in M31 with an orbital period determined. The short period also makes this nova one of the few known below the 2–3 hr orbital period gap. All of the observed characteristics strongly indicate that M31N 2013-01b harbors a massive WD and a very low mass companion, consistent with being a nova belonging to the disk population of the Andromeda galaxy.
Coronal Properties of Swift/BAT-selected Seyfert 1 AGNs Observed with NuSTAR
Authors: Kamraj N. , Harrison F. A. , Baloković M. , Lohfink A. , Brightman M. 
Published: October 2018

Abstract
The NuSTAR observatory, with its high sensitivity in hard X-rays, has enabled detailed broadband modeling of the X-ray spectra of active galactic nuclei (AGNs), thereby allowing constraints to be placed on the high-energy cutoff of the X-ray coronal continuum. We investigate the spectral properties of a sample of 46 NuSTAR-observed Seyfert 1 AGNs selected from the Swift/Burst Alert Telescope 70 month hard X-ray survey. Our measurements of the high-energy cutoff of the continuum from modeling the NuSTAR X-ray spectra are used to map out the temperature–compactness (θ–l) plane for AGN coronae. We find that most of the coronae lie clustered near the boundary for runaway pair production, suggesting that annihilation and pair production act to regulate the temperature of the corona. We discuss the implications of coronae whose high-energy cutoff may indicate a low coronal temperature on the heating and thermalization mechanisms in the corona.
The Changing-look Quasar Mrk 590 Is Awakening
Authors: Mathur S. , Denney K. D. , Gupta A. , Vestergaard M. , De Rosa G. , Krongold Yair , Nicastro F. , Collinson J. , Goad M. , Korista K. , Pogge R. W. , Peterson B. M. 
Published: October 2018

Abstract
Mrk 590 was originally classified as a Seyfert 1 galaxy, but then it underwent dramatic changes: the nuclear luminosity dropped by over two orders of magnitude and the broad emission lines all but disappeared from the optical spectrum. Here we present follow-up observations to the original discovery and characterization of this “changing-look” active galactic nucleus (AGN). The new Chandra and Hubble Space Telescope observations from 2014 show that Mrk 590 is awakening, changing its appearance again. While the source continues to be in a low state, its soft excess has re-emerged, though not to the previous level. The UV continuum is brighter by more than a factor of two and the broad Mg ii emission line is present, indicating that the ionizing continuum is also brightening. These observations suggest that the soft excess is not due to reprocessed hard X-ray emission. Instead, it is connected to the UV continuum through warm Comptonization. Variability of the Fe Kα emission lines suggests that the reprocessing region is within ∼10 lt-yr or 3 pc of the central source. The change in AGN type is neither due to obscuration nor due to one-way evolution from Type 1 to Type 2, as suggested in the literature, but may be related to episodic accretion events.
Des faillis dans l’ombre de la « Belle Époque ». Faire face à l’échec, faire face à la honte. Belgique, 1896-1914
Authors: Debruyne Emmanuel 
Published: October 2018

Quelle est la part de la honte dans le vécu d’un failli ? En confrontant la procédure de mise en faillite aux trajectoires de vie de 21 individus qui y ont été soumis dans la région de Namur au tournant des XIX e et XX e siècles, cet article explore la charge de la honte dans de telles situations et comment elle a pu influencer leur devenir et les choix qu’ils ont posés pour se reconstruire. Si l’expression de la honte apparaît rarement de manière explicite dans les pièces de procédure, le déroulement de celle-ci et les trajectoires individuelles n’en laissent pas moins cerner sa présence. Face à la procédure, les faillis s’avèrent notamment réticents à consentir à faire aveu de leur faillite, alors même que celui-ci est prescrit par la loi. Une minorité va plus loin en anticipant par la fuite la découverte de leur état. Une fois la procédure enclenchée, la révélation de la faillite par voie de presse, les confrontations avec les créanciers ou encore la vente publique ne font qu’accentuer l’humiliation. Et au lendemain de celle-ci, rares sont les faillis qui demeurent dans la localité où ils ont fait faillite. La honte affecte leur mobilité résidentielle en les dirigeant vers la grande ville, qui leur offre le soulagement de l’anonymat et la possibilité de se reconstruire socialement et économiquement. Son rôle n’est pas fini pour autant, tant elle peut peser jusqu’à l’éclatement sur le noyau familial, mais aussi pousser le failli et ses proches à la combattre et à rétablir leur honneur.
L’usure de la décentralisation, un handicap pour la France de demain ?
Authors: Olivérès Christian 
Published: October 2018

La décentralisation devait apporter une vraie amélioration dans l’administration de nos territoires. Rapprocher la décision des citoyens, renforcer la démocratie, permettre une proximité d’action, favoriser l’investissement, tels étaient ses objectifs. Après vingt ans de développement et de croissance, parfois débridée, les collectivités locales n’ont pas su dépasser de façon active et adaptée leurs limites administratives pour promouvoir des formes d’association répondant aux besoins de leurs populations. Elles se sont enfermées dans des territoires exigus et parfois devenus incohérents car les modes de vie et les attentes de nos concitoyens ont fortement changé. Elles ont été fortement affectées par les difficultés financières qu’elles ont peu anticipées. Une caste de responsables politiques et techniques s’est imposée à leur tête sans que pour autant la démocratie locale connaisse une nouvelle dynamique. À l’heure d’une recomposition du fonctionnement territorial de l’espace national, il faut trouver d’autres modalités de choix et d’arbitrage. L’usure oblige à refonder.
La Télé-fibrinolyse en Bourgogne. Une évaluation médicale et économique
Authors: Hervieu-Bègue Marie , Fagnoni Philippe , Delpont Benoît , Blanc-Labarre Christelle , Osseby Guy-Victor , Giroud Maurice , Bejot Yannick 
Published: October 2018

La Télé-fibrinolyse est reconnue comme outil incontournable pour permettre à tout citoyen de bénéficier du 1 er traitement curatif que représente la fibrinolyse dans les premières heures d’un infarctus cérébral. Utilisée à grande échelle en Bourgogne avec 21 Hôpitaux Généraux en lien avec le CHU de Dijon, une évaluation médicale et économique s’est imposée. Méthodes : Nous exposons nos travaux menés sous la coordination du Registre Dijonnais des AVC qui évalue depuis plus de 30 ans les pratiques de soins et les innovations thérapeutiques dédiées à l’Accident Vasculaire Cérébral (AVC). Résultats : Il a été démontré en Bourgogne que la Télé-fibrinolyse est aussi efficace et sécurisée que la fibrinolyse effectuée par le site expert. Sur le plan médico-économique, notre travail a montré 2 résultats : un coût de prise en charge légèrement supérieur pour les actes de fibrinolyse effectués à distance comparés à la fibrinolyse effectuée dans le site expert, expliqué par le coût des transports. un coût moyen par patient significativement plus élevé que les recettes uniquement pour la fibrinolyse effectuée dans le site expert. En conclusion : La Télé-fibrinolyse est un acte efficace et sécurisée qui va devoir s’adapter avec les prochaines recommandations sur la sélection des malades pouvant bénéficier du 2 e traitement efficace que représente la Thrombectomie Mécanique qui, pour l’instant, ne s’effectue que dans des sites experts.
« Moi je whitise jamais. » Accent, subjectivité et processus d’accommodation langagière en contexte migratoire et postcolonial
Authors: Telep Suzie 
Published: October 2018

Cet article a pour but d’analyser le rôle de la subjectivité dans les processus d’accommodation phonétique des sujets parlants en contexte migratoire et postcolonial, à partir de l’étude du cas d’un jeune adulte migrant d’origine camerounaise, militant dans une association panafricaine à Paris. La subjectivité, processus de construction du sujet, est toujours marquée par le « paradoxe de l’assujettissement » (Butler 2002), soit une tension entre assujettissement et émancipation. À partir de l’analyse de la variabilité phonostylistique dans des interactions publiques à visée politique, il s’agit de montrer dans quelle mesure l’accent fonctionne comme un lieu du désir central dans la subjectivation du sujet racisé, et manifeste une tension entre son désir d’identification à l’autre et son désir de singularisation, résultant en partie des rapports de pouvoir postcoloniaux qui contraignent sa puissance d’agir.