bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involvement of YAP-1, the Homolog of Yes-Associated Protein, in the Wnt-Mediated Neuronal Polarization in Caenorhabditis elegans
Authors: Lee Hanee , Kang Junsu , Lee Junho 
Published: May 2018

Abstract
Guidance molecules, receptors, and downstream signaling pathways involved in the asymmetric neuronal cell migration and process outgrowth have been identified from genetic studies using model organisms, most of which are evolutionarily conserved. In the nematode Caenorhabditis elegans, the roles of Wnt ligands and their receptors in the polarization of specific sets of neurons along the anterior-posterior (A-P) body axis have been well elucidated, but their downstream effectors are relatively unknown. Here, we report yap-1, encoding an evolutionarily conserved transcriptional co-activator, as a novel player in the Wnt-mediated asymmetric development of specific neurons in C. elegans. We found that the loss of yap-1 activity failed to restrict the dendritic extension of ALM neurons to the anterior orientation, which is similar to the phenotype caused by defective cwn-1 and cwn-2 Wnt gene activities. Cell-specific rescue experiments showed that yap-1 acts in the cell autonomous manner to polarize ALM dendrites. We also found that subcellular localization of YAP-1 was spatio-temporally regulated. The loss of yap-1 in Wnt-deficient mutants did not increase the severity of the ALM polarity defect of the mutants. Wnt-deficient animals displayed abnormal subcellular localization of YAP-1 in touch receptor neurons, suggesting that yap-1 may act downstream of the cwn-1/cwn-2 Wnt ligands for the ALM polarization process. Together, we have identified a new role for YAP-1 in neuronal development and our works will contribute to further understanding of intracellular events in neuronal polarization during animal development.
Hospital-Based Quality Measures for Pediatric Mental Health Care
Authors: Bardach Naomi S. , Burkhart Q , Richardson Laura P. , Roth Carol P. , Murphy J. Michael , Parast Layla , Gidengil Courtney A. , Marmet Jordan , Britto Maria T. , Mangione-Smith Rita 
Published: May 2018

BACKGROUND AND OBJECTIVES:
Patients with a primary mental health condition account for nearly 10% of pediatric hospitalizations nationally, but little is known about the quality of care provided for them in hospital settings. Our objective was to develop and test medical record–based measures used to assess quality of pediatric mental health care in the emergency department (ED) and inpatient settings.

METHODS:
We drafted an evidence-based set of pediatric mental health care quality measures for the ED and inpatient settings. We used the modified Delphi method to prioritize measures; 2 ED and 6 inpatient measures were operationalized and field-tested in 2 community and 3 children’s hospitals. Eligible patients were 5 to 19 years old and diagnosed with psychosis, suicidality, or substance use from January 2012 to December 2013. We used bivariate and multivariate models to examine measure performance by patient characteristics and by hospital.

RESULTS:
Eight hundred and seventeen records were abstracted with primary diagnoses of suicidality (n = 446), psychosis (n = 321), and substance use (n = 50). Performance varied across measures. Among patients with suicidality, male patients (adjusted odds ratio: 0.27, P &lt; .001) and African American patients (adjusted odds ratio: 0.31, P = .02) were less likely to have documentation of caregiver counseling on lethal means restriction. Among admitted suicidal patients, 27% had documentation of communication with an outside provider, with variation across hospitals (0%–38%; P &lt; .001). There was low overall performance on screening for comorbid substance abuse in ED patients with psychosis (mean: 30.3).

CONCLUSIONS:
These new pediatric mental health care quality measures were used to identify sex and race disparities and substantial hospital variation. These measures may be useful for assessing and improving hospital-based pediatric mental health care quality.
<i>Masonas y republicanas. La historia de 5 mujeres comprometidas con los valores republicanos y la masonería </i> de Natividad Ortiz Albear
Authors: Hottinger Craig Sylvia 
Published: May 2018

Reseña del libro Masonas y republicanas. La historia de 5 mujeres comprometidas con los valores republicanos y la masonería de Natividad Ortiz Albear. Oviedo: EntreAcacias, 2017. 227 páginas. ISBN: 978-94-1-3.
La franc-maçonnerie à l’île Maurice de 1778 à 1915 : entre influences françaises et britanniques, la construction d’une identité mauricienne
Authors: Venkaya Reichert Sandra Danielle Brinda 
Published: May 2018

Entrevista sobre su tesis doctoral: La franc-maçonnerie à l’île Maurice de 1778 à 1915 : entre influences françaises et britanniques, la construction d’une identité mauricienne.
Magyarországi C-vírus-hepatitises betegek vírustípus- és szubtípusmegoszlásának elemzése
Authors: Gervain Judit 
Published: May 2018

Introduction: Hepatitis C virus (HCV) shows great structural variability. Based on genome sequencing and phylogenetical analysis, 7 types and 67 subtypes can be differentiated with varying geographical distribution. It is very important to determine the HCV type/subtype prior to starting direct antiviral therapy (DAA), which has been available since 2014, because the type, dose and optimal length of medication depends on these. Aim: In Hungary, the treatment of chronic HCV patients started in 1992 with the relevant special diagnostic tests being carried out in our Molecular Diagnostic Laboratory. Determination of the nucleotide sequence of the Hungarian HCV1b NS5A/PKR-BR region and the type and subtype distribution of Hungarian patients have already been carried out. The current summary discusses the results of 6092 chronic HCV patients (175 serotypes, 5917 genotypes) based on age, gender, regions and genotype distribution changes over the period between 1996 and 2017. Method: Serotyping (1996–1999). Genotyping: hybridization (2000–2016), real-time PCR (2016–; Cobas 4800 HCV GT). Results: Genotype distribution: GT1a: 5.6%; GT1b: 84.6%; GT1a + 1b: 5.1%; GT2: 0.1%; GT3: 1.8%; GT4: 0.1%; mixed: 1.6%; GT1 (non-differentiated subtype): 1,1%. Women/men ratio: 52%/48%. The most common age category is 50–60 years (37% of all cases). There was no genotype asymmetry among the four Hungarian regions and Budapest. Over time, the prevalence of genotype 3 increased from 1.6% to 2.8% and the number of patients under the age of 40 doubled. Conclusion: There have been no substantial changes in the HCV type/subtype distribution in Hungary over the past 20 years, 1b remaining the most common. The introduction of real-time PCR method for genotyping has resulted in a major quality improvement including only a few mixed subtype results leading to more efficient drug selection. Orv Hetil. 2018; 159(Suppl 2): 2–8.
Analisis Total Plate Count (TPC) Mikroba pada Ikan Asin Kakap di Kota Sorong Papua Barat
Authors: Sukmawati Sukmawati , Hardianti Fatimah 
Published: May 2018

Ikan Asin kering merupakan salah satu produk perikanan yang banyak diminati oleh masyarakat khususnya di kota Sorong, ditandai dengan tingginya permintaan konsumen. Tingginya permintaan konsumen tidak menjamin kualitas ikan tersebut aman dari cemaran, baik cemaran zat kimia, fisika, dan cemaran mikrobiologi. Produk ikan asin kering harus terjaga dari cemaran agar dapat dikonsumsi dengan aman. Produk pangan yang aman ialah produk yang bebas dari bahan pengawet atau bahan kimia yang tidak dianjurkan seperti formalin. Selain itu, jumlah mikroba pada produk tersebut tidak boleh melewati batas standar maksimum nasional Indonesia. Tujuan penelitian ialah untuk menganalisis total plate count mikroba pada ikan asin kakap batu di kota Sorong. Metode yang digunakan adalah metode deskriptif. Hasil analisis data total plate count mikroba pada ikan asin kakap batu (Lutjanus vivanus) secara berturut-turut sebagai berikut; pada faktor pengenceran 10-4- 10-5 mulai dari sampel LG memiliki jumlah koloni 2.36 x 107 – 5 x 107 cfu/g, sampel KB 1.84 x 107 – 5.9 x107, dan sampel KS memiliki jumlah koloni 2.06 x 107- 6.7 x 107. Sehingga dapat disimpulkan bahwa ikan asin kakap batu tersebut tidak layak untuk dikonsumsi, sebab jumlah angka lempeng total (ALT) melewati batas maksimum standar nasional Indonesia.
Antioxidant and Ace Inhibitor Potential of Stripe Trevally Fish (Selaroides leptolepis) Hydrolysate
Authors: Putalan Reinal , Munifah Ifah , Nurhayati Tati , Chasanah Ekowati 
Published: May 2018

This study aimed to investigate the potency of fish protein hydrolysates (FPH) of stripe trevally fish (Selaroides leptolepis) as antioxidant and ACE inhibitor. The FPH was produced through enzymatically hydrolysis using protease produced by Bacillus licheniformis, a collection of Research and Development Center for Marine and Fisheries Product Processing and Biotechnology (RDCMFPPB). The FPH was fractionated using ultrafiltration membranes with molecular weight cut off (MWCO) of 10, 5 and 3 kDa. The hydrolysis degree, protein content, peptide content, antioxidant activity and Angiotensin-converting enzyme (ACE) inhibitor were observed. The result showed that FPH had maximum hydrolysis degree of 63.91% reached after 6 hours hydrolysis with protein content of 27.43 mg/mL and peptide content of 223.32 mg/mL. That FPH showed antioxidant activity (IC50) of 1941.06 ppm and ACE inhibitor of 87.82% at test concentration of 10 mg/mL. In the ultrafiltration step, the higher molecular cut off used, the higher protein content and peptide content. The lower molecular weight of the hydrolysate, the better antioxidant and ACE inhibitor activity. The best fractionation that produce potential product to be used as anti-hypertension was in mixture peptides between 3-5 kDa. The IC50 antioxidant activity was 1336.96 ppm and percentage of ACE inhibitor was 97.15% % (with a concentration of 10 mg/mL). From the results, protein hydrolysate of stripe trevally fish produced by enzymatic hydrolysis using local protease was potential as a functional ingredient, particularly as antihypertensive agent.
Diagnosis and Management of Hepatitis in Patients on Checkpoint Blockade
Authors: Reynolds Kerry , Thomas Molly , Dougan Michael 
Published: May 2018

Abstract

Many human tumors are recognized by the adaptive immune system, but these spontaneous antitumor responses are typically inadequate to mediate regression. Blockade of immune regulatory “checkpoint” receptors such as cytotoxic T-lymphocyte-associated antigen 4 and programmed cell death 1 can unleash antitumor immunity, resulting in tumor responses that can be durable. Alongside the enormous promise of immunotherapy for cancer, the immune dysregulation of checkpoint blockade has led to a plethora of new autoimmune adverse events. Hepatic toxicity occurs in 1%–17% of patients on immune checkpoint inhibitors, with the precise incidence dependent on both the drug used and the underlying malignancy. Hepatitis is most commonly a low-grade toxicity, but grade 3 and 4 hepatotoxicity does occur. Here we will answer frequently asked questions regarding immune-related hepatitis to assist in the recognition and management of this important condition.

Key Points
Immune related hepatitis is a potentially serious complication of checkpoint blockade. The differential for elevated liver function tests in patients on checkpoint blockade is broad. Diagnostic testing such as viral serologies, liver ultrasound, cross sectional imaging, and liver biopsy may help in the diagnosis of immune related hepatitis in select patients. Patients with underlying cirrhosis are an at risk population for whom current grading criteria may underestimate the severity of liver inflammation. Severe immune related hepatitis is best managed by a multi-disciplinary team that includes a hepatologist. Most patients with immune related hepatitis respond to corticosteroids, but a substantial fraction require treatment with a secondary immunosuppressive agent.
E4206: AMG 706 and Octreotide in Patients with Low-Grade Neuroendocrine Tumors
Authors: Lubner Sam , Feng Yang , Mulcahy Mary , O'Dwyer Peter , Giang Guang-Yu , Hinshaw J. Louis , Deming Dustin , Klein Leonard , Teitelbaum Ursina , Payne Jennifer , Engstrom Paul , Stella Philip , Meropol Neal , Benson Al 
Published: May 2018

Abstract

Lessons Learned
Rate of progression-free survival at a particular point in time, i.e., a landmark analysis, is a difficult endpoint for a heterogenous malignancy such as neuroendocrine cancer. Landmark analyses can also be complicated by evolution in the standard of care during the conduct of a clinical trial. Improvements in biomarker development would be useful in developing future clinical trials in NET to better tailor individualized therapies and assess for possible efficacy endpoints.

Background
Neuroendocrine tumors (NETs) are rare malignancies of the gastrointestinal (GI) tract that are highly vascularized and overexpress vascular-endothelial growth factor (VEGF). Sunitinib has demonstrated efficacy in the pancreatic subset of NET. This study explored the activity of another oral VEGF inhibitor, AMG 706 or motesanib, a multikinase inhibitor that targets receptor tyrosine kinases, including VEGFR1, VEGFR2, VEGFR3, KIT, RET, and PDGFR (IC50s = 2, 3, 6, 8, 59, and 84 nM, respectively).

Methods
This was a single-arm, first-line, phase II study run through the Eastern Cooperative Oncology Group. Patients with low-grade NET (as defined by central confirmation of Ki-67 of 0%–2%) were administered a flat dose of 125 mg per day orally combined with octreotide long acting-repeatable (LAR) for patients who had been on a stable dose. The primary objective was to determine the 4-month progression-free survival (PFS).

Results
Forty-four patients were evaluated per protocol. The 4-month PFS was 78.5%. The partial response rate was 13.6% (6/44), stable disease was 54.5% (24/44), 9.1% (4/44) had progressive disease, and 10/44 were not evaluable for response. Common toxicities included fatigue, hypertension, nausea, and headache, and most were grade 1–2. Median PFS was 8.7 months, and overall survival was 27.5 months.

Conclusion
Motesanib (AMG 706) demonstrated a 4-month PFS that met the per-protocol definition of efficacy. Fatigue and hypertension were the most common toxicities, and few grade 3–4 toxicities were encountered. The progression-free survival of 8.7 months in all NETs merits further study.
Konya il merkezinde gastroözofageal reflü hastalığı prevalansı
Authors: ÖZER ÇAKIR Özlem , ÇİZMECİOĞLU Ahmet , BIYIK Murat , ÇİFÇİ Sami , ATASEVEN Hüseyin , POLAT Hakkı , DEMİR Ali 
Published: May 2018

Giriş ve Amaç: Gastroözofageal reflü hastalığı üst gastrointestinal kanalın sık rastlanılan bir hastalığıdır. Anatomik lokalizasyonu nedeniyle özofagusa komşuluğu olan organların hastalıklarını taklit edebildiği gibi; asıl hastalığın şikayetini maskeleyebilmekte hatta oluşan komplikasyonları da başka organların fonksiyonlarını bozabilmektedir. Dünyada batı tipi yaşantısı olan toplumlarda daha sık görülmektedir. Türkiye’de hastalık epidemiyolojisi ile sınırlı veri vardır. Gereç ve Yöntem: Yaşadığımız çevrenin prevalansını belirleyebilmek amaçlı yapılan çalışmada Konya İli Merkez İlçelerinde önceden belirlenmiş rastgele adreslerdeki 2000 kişi ile anket görüşmesi yapılmıştır. Bulgular: 1188 kişi ile anket tamamlanabilmiş, (%59 geri dönüş oranı), katılımcıların 581’i kadın (%48.9), 607’si erkek (%51.1), yaş ortalaması 41.34±12.8 olarak hesaplanmıştır. Aylık semptomlar göz önüne alındığında aylık %10,9 prevalans bulunmuştur. Cinsiyet, medeni hal, eğitim düzeyi, meslek ve gelir durumu reflü ile ilişkili bulunmazken yaş ve vücut kitle indeksi ile korelasyon saptanmıştır (p&lt;0.05). Sonuç: Bulunan sonuç itibariyle Konya İli merkez ilçelerinde her üç kişiden birinin kilolu ya da obez olduğu saptanmış, reflü prevalansının batı ülkelerine yakın olduğu görülmüştür.
Alerjik rinitli bir olguda eozinofilik özofajit
Authors: DÜŞÜNÜR GÜNSEN Fatma , BOR Serhat , SEZAK Murat , SİN Aytül Zerrin 
Published: May 2018

Eozinofilik özofajit; özofagus mukozasında eozinofilik infiltrasyon ile karakterize kronik, immün aracılı bir tablodur. Erişkinlerde özofageal disfonksiyon semptomları olan disfaji, gıda takılma hissi, regürjitasyon, kusma ve göğüs ağrısı en sık görülen yakınmalardır. Tanı hastanın semptomları eşliğinde endoskopik ve histolojik bulgular ile konur. Bu olguda alerjik riniti ve eozinofilik özofajiti olan bir hasta tanımlanmaktadır
Design and Analysis of Balloon-expandable Stainless Steel Coronary Stent
Authors: Pan Xiaolin , Shi Gengqiang , Li Yuan , Wu Shanshan , Chen Long 
Published: May 2018

<p>This thesis uses “Volume Control” ballon-stent model, and according to results of deformation of a stent and vascular during implantation, we obtain the stress contours of the stent during implantation. The results conclude by ANSYS simulation show that during the implantation process, expansion of balloon body will make the narrow part of the blood wall fragment tough. After placement of the stent, due to blood flow in vessel makes that the inner wall of blood vessels has uneven distribution of shear stress; And, in the vicinity of the stent structure, it has a lower <sup>[7]</sup><sup> </sup>shear stress to vessel wall. During the expansion of the stent, the maximum principal stress concentrate on the connection between coronary stent itself and stiffeners.</p>
SIMULASI ANALISIS KORESPONDENSI UNTUK DATA TRACER STUDI DI TINGKAT SEKOLAH MENENGAH [SIMULATION OF A CORRESPONDENCE ANALYSIS FOR A TRACER STUDY WITH HIGH SCHOOL ALUMNI]
Authors: Yohansa Meicheil 
Published: May 2018

<p>A Tracer Study is research or a study of alumni tracking. Graduates or alumni are considered to have the most appropriate capacity to provide feedback as far as an evaluation of the institution is concerned. That is why the implementation of a Tracer Study is often attributed to the efforts of evaluation and improvement of the education system of an institution. Through the implementation of a Tracer Study, institutions can obtain information about possible deficiencies in the educational and learning process. In Indonesia, a Tracer Study is generally implemented to track alumni of a university and their associations in the working world. By seeing the usefulness of a Tracer Study at the university level, this study conducted an implementation of a Tracer Study at the high school level. The implementation itself focused on the determination of the respondent and the preparation of the questionnaire as a research instrument by accounting for the differences in the characteristics of high school and university graduates. The Tracer Study results were analyzed using correspondence analysis with <em>Eigenvalue Decomposition (EVD</em>). Data analysis was carried out on a case study about the relationship between non-academic activities and communication capabilities.</p><p><strong>BAHASA INDONESIA ABSTRAK: </strong><em>Tracer Study </em>dikenal sebagai suatu penelitian atau studi mengenai pelacakan alumni. Sedangkan alumni itu sendiri dianggap memiliki kapasitas yang paling tepat dalam memberikan umpan balik sebagai evaluasi terhadap institusi yang bersangkutan. Sehingga pada pelaksanaannya <em>Tracer Study </em>kerap kali dikaitkan dengan upaya evaluasi serta perbaikan sistem pendidikan dari suatu institusi. Melalui pelaksanaan <em>Tracer Study, </em>lembaga penyelenggara pendidikan memungkinkan untuk memperoleh informasi kemungkinan kekurangan dalam proses pendidikan dan pembelajaran. Di Indonesia, <em>Tracer Study </em>umumnya dilaksanakan untuk melacak alumni dari suatu perguruan tinggi dengan asosiasi terhadap dunia industri kerja. Melihat gambaran kebermanfaatan <em>Tracer Study </em>di beberapa perguruan tinggi, maka pada penelitian ini dilakukan adaptasi <em>Tracer Study </em>untuk dilaksanakan pada tingkat satuan pendidikan sekolah menengah atas (SMA). Adaptasi pelaksanaan <em>Tracer Study </em>di SMA menitikberatkan pada penentuan responden dan penyusunan kuesioner sebagai instrumen penelitian. Hal ini sebagai akibat dari perbedaan karakteristik lulusan SMA dan perguruan tinggi. Hasil <em>Tracer Study </em>dianalisis menggunakan Analisis Korespondensi dengan dekomposisi nilai eigen. Analisis data dilakukan terhadap studi kasus mengenai hubungan antara kegiatan non akademik dengan kemampuan komunikasi.</p>
THE USE OF REALISTIC MATHEMATICS EDUCATION IN TEACHING THE CONCEPT OF EQUALITY
Authors: Theodora Febe Ratu Nada , Hidayat Dylmoon 
Published: May 2018

<p>Algebra is one of the most fundamental concepts in learning mathematics and the concept of equality is an essential part of learning algebraic topics. However, many students find this concept difficult to understand. The problem is the difficulty of the content and how to teach it. In order to solve the problem, this paper reviews the use of the theory of Realistic Mathematics Education (RME) in teaching the concept of equality. RME is a process of teaching and learning mathematics in a contextual way as mathematics is considered as a human activity. This paper aims to review the use of the RME theory in teaching the concept of equality within the Biblical perspective as the parameter of the implementation for mathematics as one of God’s tools to reveal His glory and wisdom. The method used in this paper was literature review which used literature findings as the resources. According to the literature research, it was found that the main problem in teaching and learning the concept of equality was students’ misconception of equality. The use of the RME theory can help teachers to teach the “equality” concept to help student learn contextually. </p><p><strong>BAHASA INDONESIA ABSTRAK<strong></strong>: </strong>Aljabar merupakan salah satu konsep paling dasar dalam pembelajaran matematika mendalam dan konsep persamaan merupakan bagian yang penting dalam mempelajari topik-topik aljabar. Namun ada murid-murid yang mendapati bahwa konsep persamaan sulit dimengerti. Permasalahannya adalah seputar sulitnya materi yang dipelajari dan cara pengajarannya. Untuk mencari solusi dari permasalahan tersebut, makalah ini akan mengkaji penggunaan teori Matematika Realistis dalam pengajaran konsep persamaan. Matematika Realistis adalah proses belajar mengajar matematika kontekstual yang memandang matematika sebagai aktifitas manusia. Makalah ini bertujuan untuk mengkaji penggunaan teori Matematika Realistis dalam pengajaran konsep persamaan di dalam perspektif Alkitabiah sebagaimana matematika adalah alat Allah untuk menyingkapkan kemuliaan dan hikmat-Nya. Metode yang digunakan dalam makalah ini adalah studi literatur yang menggunakan temuan-temuan literatur sebagai sumber. Berdasarkan studi literatur, masalah utama dalam pengajaran konsep persamaan adalah adanya miskonsepsi pada pemahaman murid dan menggunakan teori Matematika Realistis, pengajar dapat mengajar konsep “keseimbangan” untuk membantu murid belajar secara kontekstual.</p>