bluuebunny/crossref_metadata_2025_split huggingface dataset:
FoxF1 is Required for Ciliogenesis and Distribution of Sonic Hedgehog Signaling Components in Cilium
Authors: Huang Lu , Tjakra Marco , Luo Desha , Wen Lin , Lei Daoxi , Wang Jinxuan , Yin Tieying , Zhang Xiaojuan , Huang Junli , Wang Yeqi , Wang Guixue 
Published: April 2019

Background:In vertebrates, cilium is crucial for Hedgehog signaling transduction. Forkhead box transcriptional factor FoxF1 is reported to be associated with Sonic Hedgehog (Shh) signaling in many cases. However, the role of FoxF1 in cilium remains unknown. Here, we showed an essential role of FoxF1 in the regulation of ciliogenesis and in the distribution of Shh signaling components in cilium.Methods:NIH/3T3 cells were serum starved for 24h to induce cilium. Meanwhile, shRNA was used to knockdown the FoxF1 expression in the cells and CRISPR/Cas9 was used to generate the FoxF1 zebrafish mutant. The mRNA and protein expression of indicated genes were detected by the qRT-PCR and western blot, respectively. Immunofluorescence staining was performed to detect the cilium and Shh components distribution.Results:FoxF1 knockdown decreased the cilium length in NIH/3T3 cells. Meanwhile, the disruption of FoxF1 function inhibited the expression of cilium-related genes and caused an abnormal distribution of Shh components in the cilium. Furthermore, homozygous FoxF1 mutants exhibited defective development of pronephric cilium in early zebrafish embryos.Conclusion:Together, our data illustrated that FoxF1 is required for ciliogenesis in vitro and in vivo and for the proper localization of Shh signaling components in cilium.
Inhibition of SOX15 Sensitizes Esophageal Squamous Carcinoma Cells to Paclitaxel
Authors: Zhang Ming , Wang Jianying , Gao Tianwei , Chen Xin , Xu Yan , Yu Xiaoting , Guo Xianyang , Zhuang Rong , Li Ziwei , Wu Hongjin , Yu Juehua 
Published: April 2019

Background:
SOX15 is a crucial transcription factor involved in the regulation
of embryonic development and in the cell fate determination. It is also an important
mediator of tumorigenesis in cancer.

Methods:
Here, we sought to explore the expression patterns and biological functions of
SOX15 in esophageal squamous cell carcinomas (ESCC). SOX15 was found aberrantly
overexpressed in ESCC tumors.

Results:
Experimentally, inhibition of SOX15 through RNAi suppressed cell proliferation
in ESCC cells and sensitized cancer cells to paclitaxel, but not to Cisplatin. Moreover,
inhibition of SOX15 significantly repressed the expression of genes associated with
WNT and NOTCH signaling pathways, which may contribute to the increased sensitivity
to paclitaxel.

Conclusion:
In conclusion, the current study revealed that inhibition of SOX15 in ESCC
cells sensitizes the ESCC cells to paclitaxel, suggesting that the SOX15 expression level
may predict the therapeutic outcomes for paclitaxel treatment for ESCC.
Therapeutic Exploitation of Viral Interference
Authors: Kovesdi Imre , Bakacs Tibor 
Published: April 2019

:Viral interference, originally, referred to a state of temporary immunity, is a state whereby infection with a virus limits replication or production of a second infecting virus. However, replication of a second virus could also be dominant over the first virus. In fact, dominance can alternate between the two viruses. Expression of type I interferon genes is many times upregulated in infected epithelial cells. Since the interferon system can control most, if not all, virus infections in the absence of adaptive immunity, it was proposed that viral induction of a nonspecific localized temporary state of immunity may provide a strategy to control viral infections. Clinical observations also support such a theory, which gave credence to the development of superinfection therapy (SIT). SIT is an innovative therapeutic approach where a non-pathogenic virus is used to infect patients harboring a pathogenic virus.:For the functional cure of persistent viral infections and for the development of broad- spectrum antivirals against emerging viruses a paradigm shift was recently proposed. Instead of the virus, the therapy should be directed at the host. Such a host-directed-therapy (HDT) strategy could be the activation of endogenous innate immune response via toll-like receptors (TLRs). Superinfection therapy is such a host-directed-therapy, which has been validated in patients infected with two completely different viruses, the hepatitis B (DNA), and hepatitis C (RNA) viruses. SIT exerts post-infection interference via the constant presence of an attenuated non-pathogenic avian double- stranded (ds) RNA viral vector which boosts the endogenous innate (IFN) response. SIT could, therefore, be developed into a biological platform for a new “one drug, multiple bugs” broad-spectrum antiviral treatment approach.
Infantile Hydrocephalus: Health-Related Quality of Life Outcome following Ventriculoperitoneal Shunt
Authors: Eloqayli Haytham , Alyousef Ali 
Published: April 2019

Aims:
To investigate the impact of Ventriculo-Peritoneal Shunt (VPS) on the Health-Related Quality of Life (HRQOL) of children with the infantile hydrocephalus who underwent their first shunt insertion in the first year of life. To compare the outcome of health domains according to sex, follow-up period, etiology and shunt valve type (fixed versus programmable pressure).

Methods:
102 children ≤1 years old at the time of new-onset hydrocephalus and shunt insertion. Age-appropriate PedsQL 4.0 versions were completed by the parents or caregivers with the assistance of single neurosurgery resident. Patients were divided into subgroups according to etiology; neural tube defect associated hydrocephalus (NTD-H), intra-ventricular hemorrhage associated with infantile hydrocephalus (IVH-H) and according to the shunt valve type; fixed versus programmable. Statistical analyses were performed using SPSS, IBM version 20. PedsQL 4.0 was presented using mean and standard deviations.

Results:
A decreasing social domain score at 1-3 years follow up (n=61) compared to 1 year follow up (n=41) was observed. The two groups did not differ significantly in sex distribution. The mean cognitive score was significantly lower in patients with IVH-H of prematurity compared to NTD-H. Better physical and cognitive domains in programmable shunts were compared to fixed pressure type.

Conclusion:
IVH-H associated with worse cognitive function possibly due to associated brain damage was reported. With long-term follow-up, social function decline probably due to the patients’ awareness of their disability was observed. Programmable shunt valve is recommended over fixed type due to the improvement in physical and cognitive functions. Sex of the patients did not affect the outcome.
Comparison of the Effects of Three Hangboard Strength and Endurance Training Programs on Grip Endurance in Sport Climbers
Authors: López-Rivera Eva , González-Badillo Juan José 
Published: April 2019

Abstract
Intermittent isometric endurance of the forearm flexors is a determinant factor of sport climbing performance. However, little is known about the best method to improve grip endurance in sport climbing regarding maximal or intermittent dead-hang training methods. The aim of this study was to compare the effects of three 8-week finger training programs using dead-hangs (maximal, intermittent, and a combination) on grip endurance. Twenty-six advanced sport climbers (7c+/8a mean climbing ability) were randomly distributed among three groups: maximal dead-hangs with maximal added weight on an 18 mm edge followed by MaxHangs on minimal edge depth; intermittent dead-hangs using the minimal edge depth, and a combination of both. The grip endurance gains and effect size were 34% and 0.6, respectively, for the group following maximal dead-hang training, 45% and 1, respectively, for the group following intermittent dead-hang training, and 7% and 0.1, respectively, for the group applying the combination of both training methods. Grip endurance increased significantly after 4 weeks in the group performing intermittent dead-hangs (p = 0.004) and after 8 weeks in both groups performing intermittent dead-hangs (p = 0.002) and MaxHangs (p = 0.010). The results suggest that the intermittent dead-hangs training method seems to be more effective for grip endurance development after eight week application in advanced sport-climbers. However, both methods, maximal and intermittent dead-hangs, could be alternated for longer training periods
Multiobjective Improved Particle Swarm Optimisation for Transmission Congestion and Voltage Profile Management using Multilevel UPFC
Authors: Rao Mallavolu Malleswara , Ramadas Geetha 
Published: April 2019

Abstract
This paper proposes a multiobjective improved particle swarm optimisation (IPSO) for placing and sizing the series modular multilevel converter-based unified power flow controller (MMC-UPFC) FACTS devices to manage the transmission congestion and voltage profile in deregulated electricity markets. The proposed multiobjective IPSO algorithm is perfect for accomplishing the close ideal distributed generation (DG) sizes while conveying smooth assembly qualities contrasted with another existing algorithm. It tends to be reasoned that voltage profile and genuine power misfortunes have generous upgrades along ideal speculation on DGs in both the test frameworks. The proposed system eliminates the congestion and the power system can be easily used to solve complex and non-linear optimisation problems in a real-time manner.
RDChiral: An RDKit Wrapper for Handling Stereochemistry in Retrosynthetic Template Extraction and Application
Authors: Coley Connor W. , Green William H. , Jensen Klavs F. 
Published: April 2019

There is a renewed interest in computer-aided synthesis planning, where the vast majority of approaches require the application of retrosynthetic reaction templates. Here, we introduce an open source Python wrapper for RDKit designed to provide consistent handling of stereochemical information in applying retrosynthetic transformations encoded as SMARTS strings. RDChiral is designed to enforce the introduction, destruction, retention, and inversion of tetrahedral centers as well as the cis/trans chirality of double bonds. We also introduce an open source implementation of a retrosynthetic template extraction algorithm to generate SMARTS patterns from atom-mapped reaction SMILES strings. In this manuscript, we describe the implementation of these two pieces of code and illustrate their use through many examples.The two .json.gz files can be generated from the open source USPTO data available at https://figshare.com/articles/Chemical_reactions_from_US_patents_1976-Sep2016_/5104873 using the code contained in the rdchiral GitHub repository. They are placed here for convenience if you would prefer to copy them into the templates/data subfolder instead of creating them from the source .rsmi file.
Sistem Informasi E-Procurement Untuk Mewujudkan Proses Pelelangan Barang dan Jasa Yang Transparan, Efisien dan Akuntable
Authors: Qotimah Khusnul 
Published: April 2019

E-procurement adalah suatu proses pengadaan barang dan jasa secara online melalui internet, dengan adanya e-procurement diharapkan proses akan menjadi transparan dan dapat mudah diawasi oleh peserta lelang dan masyarakat sehingga proses pengadaan barang dan jasa akan adil (fair).Sistem Informasi E-Procurement adalah Sistem Informasi berbasis web yang digunakan sebagai sarana untuk membantu proses pengadaan barang dan jasa mulai dari proses pelelangan, pendaftaran pelelang, data pelelangan, data penawar, proses penawaran hingga proses seleksi pemenang. Ada 4 pengguna dalam Sistem Informasi E-procurement ini, yaitu : Admin, Pelelang, Penawar dan Tamu.Pemilihan penyedia barang dan jasa dengan menggunakan sistem e-Procurement diharapkan untuk mewujudkan tujuan pelaksanaan pengadaan barang dan jasa pemerintah yang efektif, efisien, transparan, adil atau tidak diskriminatif dan akuntabel.
Sistem Informasi Inventori Gudang Untuk Mengontrol Persediaan Barang Pada Gudang Studi Kasus : PT.Alaisys Sidoarjo
Authors: Agusvianto Hendra 
Published: April 2019

Sebagai perusahaan Tknologi distributor, PT.Alaisys selalu melakukan pengawasan dan Percatatan terhadap barang persedian. Pelaporan dari gudang ke kantor pusat di lakukan dengan cara menyalindata dari kartu ke dalam microsof office excel. Laporan dalam format excel tersebut harus di kirim via email atau Gadget. Sistem tersebut menjadikan pihak kantor pusat tidak dapat mengetahui data dari gudang dengan efisien. Dari permasalahan tersebut di atas, PT.Alaisys memerlukan adanya aplikasi aplikasi sistem inventory gudang berbasis web. Aplikasi dapat di gunakan dalam mengiventariskan produk yang ada pada stok stok di gudang yang meliputi pencatatan, pengolahan, dan pelaporan data data pada persediaan gudang. Dengan adanya Aplikasi berbasis web, kantor pusat dapat melihat laporan dari gudang dengan tepat sasaran, akurat, dan efisien. Kata Kunci: Sistem Informasi Inventory, Web Sistem Informasi, PHP, dan DFD
Online Assignment Submission System untuk Efisiensi Pengelolaan Tugas Mahasiswa
Authors: Suryawinata Mohammad , Azizah Nuril Lutvi , Taurusta Cindy 
Published: April 2019

Dalam sebuah proses pendidikan, mahasiswa akan mengikuti beberapa tahap. Mulai dari perkuliahan, mengerjakan tugas-tugas, dan mengikuti ujian, baik itu tengah semester maupun akhir semester. Proses ujian akhir semester secara tertulis masih banyak dilakukan pada matakuliah yang tidak menerapkan proyek akhir berupa perancangan sebuah system, produk atau karya tulis. Banyak dosen di Universitas Muhammadiyah Sidoarjo selama ini masih menggunakan kertas untuk proses penugasan mahasiswa seperti membuat makalah atau portofolio. Evaluasi dalam merupakan satu hal yang tidak bisa dipisahkan dari proses pendidikan. Banyak istilah yang digunakan untuk melakukan evaluasi pendidikan antara lain tes, asesmen, ujian, dan lain sebagainya. Evaluasi digunakan untuk mengetahui sejauh mana peserta didik memahami dan mempelajari materi. Selain itu evaluasi juga digunakan untuk mengetahui sejauh mana peserta didik mencapai tujuan pembelajaran. Penugasan atau pemberian tugas merupakan salah satu cara evaluasi dalam proses belajar mengajar dengan memberikan tugas pada peserta didik. Dalam penelitian ini, peneliti akan melakukan pengembangan sistem pengumpulan tugas secara online dengan mempertimbangkan efektifitas waktu dan biaya yang bisa diminimalisir. Pengumpulan tugas secara online ini penting karena dapat membantu mahasiswa dalam pengumpulan tugas agar tidak saling menunggu dengan mahasiswa lain. Serta untuk dosen, manfaat dari sistem ini diharapkan bisa menghemat waktu dalam mengorganisir tugas dan juga mengetahui urutan mahasiswa yang mengumpulkan tugas dari awal hingga akhir deadline. Hasil penelitian menunjukkan bahwa waktu pengumpulan tugas dan pengelolaan tugas oleh dosen menjadi lebih efektif.
Pengembangan Fitur Penilaian dan Perangkingan pada Automatic Programming Assessment Tools
Authors: Asmunin Asmunin , Harimurti Rina , Qoiriah Anita , Nurhidayat Andi iwan 
Published: April 2019

Praktikum Pemrograman Dasar merupakan wadah yang efektif dan telah terbukti untuk meningkatkan kemampuan mahasiswa dalam pemrograman. Dalam kegiatan ini, mahasiswa diberikan permasalahan, kemudian mahasiswa menyusun algoritma dan mencari solusi dan menuliskan kode program. Setelah program selesai ditulis, setiap mahasiswa harus melakukan asistensi dan demo ke dosen pengampu/asisten praktikum. Dalam melakukan demo ke dosen pengampu/asisten membutuhkan waktu yang tidak sedikit, dan tidak hanya sekali. Aplikasi Automatic Programming Assessment digunakan untuk melakukan evaluasi secara mendalam terhadap source code yang diunggah oleh praktikan. Aplikasi ini akan melakukan pengecekan jenis bahasa pemrograman yang digunakan, ukuran file, error syntax, lama eksekusi, runtime error, time limit, wrong answer, dan compilation error. Jika hasil evaluasi tidak ada masalah, maka program dianggap benar (Accepted). Praktik/mahasiswa dapat secara live menulis kode program kemudian dikirim, atau langsung mengirim file kode program. Terhadap file yang terkirim, aplikasi akan melakukan evaluasi dan akan menampilkan hasil evaluasi. hasil pengujian yang dilakukan dapat disimpulkan bahwa fitur penilaian otomatis terhadap kode program yang dikirim oleh mahasiswa dapat berjalan dengan baik. Hal ini dibuktikan dengan kesamaan hasil penilaian antara penilaian manual dan penilaian melalui aplikasi. Fitur rangking juga dapat menampilkan urutan mahasiswa yang telah memperoleh nilai dengan baik berdasarkan nilai (point) dan persentase AC (Accepted Answer)
KONSEPTUALISASI METAFORA DALAM RUBRIK OPINI KOMPAS: KAJIAN SEMANTIK KOGNITIF
Authors: Haula Baiq , Nur Tajudin 
Published: April 2019

Conceptualization of Metaphors in the 2018 Kompas Opinion Rubric: Cognitive Semantic Studies. This study aims to reveal the types of conceptual metaphors in Kompas opinion writing in 2018. This type of research includes qualitative research that is descriptive analysis. The method used in this study is the Agih method with advanced techniques for Direct Elements. The results showed that the ontology metaphor was dominantly found in writing opinion rubrics compared to structural and orientational metaphors. The author of opinion transfers more of the construction of his abstract ideas into objects that have physical properties. The characteristic of metaphor found that metaphor is associated with nature, such as shipwreck, collapse, storm sweeping, farming, and blowing. Image schemes depicted from the concepts of dominant metaphors represent the concept of existence.
The "Glorifications" of Herisenef in the Museo Egizio (P. Turin Cat. 2117 (R 08))
Authors: Gill Ann-Katrin 
Published: April 2019

This paper publishes for the first time and discusses P. Turin Cat. 2117 (R 08). The owner of the manuscript is identified and information regarding his family and career collected and analysed. This is followed by a presentation of parallels for the texts, a discussion of the layout and palaeography of the manuscript, a hieroglyphic transcription, and a transliteration and translation, as well as a commentary on the general content and on specific textual passages. The paper is concluded by an investigation of the specific combination of spells that Herisenef chose for his funerary papyrus.
ملخص البحث:
تُنشر هذه الدراسة لأول مرة وتناقش بردية رقم P. Turin Cat. 2117 (R 08) بالمتحف المصري بتورينو، تم التعرف على صاحب هذه المخطوطة، كما تم جمع المعلومات المتعلقة بعائلته وحياته المهنية وتحليلها. تبع ذلك عرض متوازي للنصوص ومناقشة تصميم المخطوطة ودراستها من خلال علم الخطاطة وكتابتها الهيروغليفية ونقلها حرفيًا وترجمتها بالإضافة إلى تعليق عام على المحتوى بشكل عام وعلى قطع نصية محددة. اختُتمت الدراسة ببحث مجموعة محددة من التعاويذ التي اختارها "حِري-سنف" لبرديته الجنائزية.
Vuoden 2015 ”pakolaiskriisi” ja sarjakuva-aktivismi Suomessa
Authors: Kauranen Ralf , Löytty Olli , Nikkilä Aura , Vuorinne Anna 
Published: April 2019

Syksyn 2015 niin sanottu pakolaiskriisi herätti suomalaisen sarjakuvakentän aktiivit toimimaan. Aktiivisuus näkyi muuttoliikettä käsittelevinä sarja- ja pilakuvina, julkaisu- ja näyttelytoimintana, sarjakuvaoriginaalien myymisenä turvapaikanhakijoiden auttamiseksi sekä turvapaikanhakijoille suunnattuina työpajoina. Artikkelissa kuvataan ja analysoidaan sarjakuvakentällä syntyneitä reaktioita ja tulkitaan toimintaa esteettisen kosmopolitanismin käsitteen avulla, jolla tarkoitetaan paitsi taiteelle ominaista mielikuvituksen ja kuvittelun rajattomuutta, myös taiteen mahdollisuuksia käsitellä siirtolaisuuden ja liikkeen läpäisemää maailmaa. Vaikka näkökulmamme on taiteensosiologinen, siinä analysoidaan tilanteessa syntyneitä sarjakuvia myös tekstilähtöisesti. Analysoitavina ovat ajankohtaiset pilakuvat, Suomen sarjakuvaseuran antirasistinen Nyt riittää!-pamfletti, Sami Nyyssölän ja Anssi Vieruahon irakilaisen turvapaikanhakijan pakoa kuvaava 24 päivää-albumi sekä työpajoissa valmistuneet ns. ruohonjuurisarjakuvat.
Artikkelissa esitämme, että auttamishaluna näkyvä avoimuus tulijoita kohtaan, paikalliseen poliittiseen keskusteluun osallistuminen antirasistisesta näkökulmasta ja pyrkimykset tuoda turvapaikanhakijoiden omat kuvaukset kokemuksistaan osaksi julkista keskustelua perustuvat sarjakuvakulttuurille ominaiseen transnationaaliseen yhteisöllisyyteen. Samalla tällaiset auttamisen tavat voi tulkita taiteen, ja tässä erityisesti sarjakuvakerronnan, kosmopoliittisuudesta kumpuavaksi eettiseksi näkökulmaksi.
Vuoden 2019 viimeisen Avaimen teemana matkakirjallisuus
Authors: Kuortti Joel 
Published: April 2019

Numerossa 4/2019 pureudutaan matkakirjallisuuden tutkimuksen moninaiseen kenttään. Tutkimusala tarjoaa tärkeitä näkökulmia esimerkiksi siihen, miten subjektiivista kokemusta, tilaa ja paikkaa, identiteettejä, vierauden kohtaamista ja kulttuurista vuorovaikutusta voidaan esittää kirjallisuuden keinoin. Matkakirjallisuutta tutkittiin aiemmin paljolti historiallisena, maantieteellisenä ja antropologisena aineistona, mutta tutkimusalan vakiinnuttua huomiota on alettu kiinnittää myös matkakirjallisuuden poetiikkaan, muotoihin ja teemoihin. Tällä hetkellä aiheen kansainvälinen tutkimus on vilkasta, monipuolista ja tieteidenvälistä. Alan vakiintuneisuudesta kertovat muun muassa säännöllisesti ilmestyvät tieteelliset lehdet ja julkaisusarjat sekä yliopistollinen opetus ja kansainväliset konferenssit.
Avaimen teemanumerossa esitellään tuoretta suomalaista matkakirjallisuuden tutkimusta. Numeron artikkelit ja katsaukset kattavat laajan valikoiman kielialueita ja historiallisia aikakausia. Huomio kiinnittyy muun muassa kuvallisuuteen, monikielisyyteen, tilan kysymyksiin, tosiperäisen esityksen ja fiktion suhteeseen sekä matkakirjallisuuden historiaan. Esiin nousevat myös kysymykset matkakirjallisten lajien määrittelystä. Missä määrin lajia määrittävät tietyt tekstin piirteet tai lukijan odotukset ja missä määrin taas yhteys matkan kokemukseen?
Jos haluat tarjota artikkelia tai muuta kirjoitusta (essee, katsaus, kirja-arvio, konferenssiraportti tms.), ota yhteyttä teemanumeron päätoimittajiin.
Lisätietoja numeron päätoimittajilta: Kai Mikkonen (kai.mikkonen@helsinki.fi), Ilona Lindh (ilona.lindh@helsinki.fi)
Ley y violencia a través de una revisión crítica del derecho natural
Authors: Iribarne Gabriel 
Published: April 2019

<p>La propuesta de este artículo es problematizar el ius-naturalismo y el contractualismo a partir de cuatro categorías: Dicotomía racionalidad-irracionalidad, Estado de naturaleza-estado de sociedad, Libertad, Paz. Estas cuestiones aluden a un estrato que atraviesa toda la conflictividad presente en dichas teorías: el problema del origen planteado por Foucault en Nietzsche, la genealogía y la historia. A partir de ello se propone retomar la problematización que la violencia introduce en la conformación o establecimiento del derecho, en tanto que legitima un Estado. Sobre este último punto, se considera fundamental la concepción que el filósofo italiano Roberto Esposito tiene acerca del derecho y la violencia. Esta interpretación, según afirma el mismo pensador, es elaborada a partir de un punto de vista histórico desde el cual puede apreciarse el circuito pendular entre poder y fuerza.</p><p> </p>