bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water Soluble Vitamins and their Role in Diabetes and its Complications
Authors: Deshmukh Shreeya V. , Prabhakar Bala , Kulkarni Yogesh A. 
Published: September 2019

Background:
Diabetes is a metabolic disorder associated with abnormally high levels of
glucose in the blood due to inadequate production of insulin or inadequate sensitivity of cells to the action
of insulin. Diabetes has become an increasing challenge in the world. The predicted diabetic population
according to the World Health Organization is 8.7% between the age group 20-70 years. There
are many complications linked to prolonged high blood glucose levels, such as microvascular complications
and macrovascular complications. Vitamins play an important role in glucose metabolism and
the potential utility of supplementation is relevant for the prevention and/or management of diabetes
mellitus and its complications.

Methods:
Literature search was performed using various dataset like PUBMED, EBSCO, ProQuest,
Scopus and selected websites like the National Institute of Health and the World Health Organization.

Result:
Water-soluble vitamins have been thoroughly studied for their activity in diabetes and diabetic
complications.

Conclusion:
Water-soluble vitamins like B1, B3, B6, B7, B9 and B12 have notable effects in diabetes
mellitus and its related complications like nephropathy, neuropathy, retinopathy and cardiomyopathy.
Anti-inflammatory Property of AMP-activated Protein Kinase
Authors: Noor Humaira B. , Mou Nusrat A. , Salem Liyad , Shimul Md F.A. , Biswas Soumick , Akther Rowshon , Khan Salma , Raihan Sabbir , Mohib Md M. , Sagor Md A.T. 
Published: September 2019

Background:
One of the many debated topics in inflammation research is
whether this scenario is really an accelerated form of human wound healing and immunityboosting
or a push towards autoimmune diseases. The answer requires a better understanding
of the normal inflammatory process, including the molecular pathology underlying the
possible outcomes. Exciting recent investigations regarding severe human inflammatory
disorders and autoimmune conditions have implicated molecular changes that are also
linked to normal immunity, such as triggering factors, switching on and off, the influence
of other diseases and faulty stem cell homeostasis, in disease progression and development.

Methods:
We gathered around and collected recent online researches on immunity, inflammation,
inflammatory disorders and AMPK. We basically searched PubMed, Scopus
and Google Scholar to assemble the studies which were published since 2010.

Results:
Our findings suggested that inflammation and related disorders are on the verge
and interfere in the treatment of other diseases. AMPK serves as a key component that prevents
various kinds of inflammatory signaling. In addition, our table and hypothetical figures
may open a new door in inflammation research, which could be a greater therapeutic target
for controlling diabetes, obesity, insulin resistance and preventing autoimmune diseases.

Conclusion:
The relationship between immunity and inflammation becomes easily apparent.
Yet, the essence of inflammation turns out to be so startling that the theory may not be
instantly established and many possible arguments are raised for its clearance. However,
this study might be able to reveal some possible approaches where AMPK can reduce or
prevent inflammatory disorders.
Novel Self-Pipelining Approach for Speed-Power Efficient Reliable Binary Multiplication
Authors: Saha Aloke , Pal Rahul , Ghosh Jayanta 
Published: September 2019

Background:
The present study explores a novel self-pipelining strategy that can enhance
speed-power efficiency as well as the reliability of a binary multiplier as compared to state-of-art register
and wavepipelining.

Method:
Proper synchronization with efficient clocking between the subsequent self-pipelining stages
has been assured to design a self-pipelined multiplier. Each self-pipelining stage consists of self-latching
leaf cells that are designed, optimized and evaluated by TSMC 0.18μm CMOS technology with 1.8V
supply rail and at 25°C temperature. The T-Spice transient response and simulated results for the designed
circuits are presented. The proposed idea has been applied to design 4-b×4-b self-pipelined Wallace-
tree multiplier. The multiplier was validated for all possible test patterns and the transient response
was evaluated. The circuit performance in terms of propagation delay, average power and Power-Delay-
Product (PDP) is recorded. Next, the decomposition logic is applied to design a higher-order multiplier
(i.e., 8-bit×8-bit and 16-bit×16-bit) based on the proposed strategy using 4-bit×4-bit self-pipelined multiplier.
The designed multiplier was also validated through extensive TSpice simulation for all the required
test patterns using W-Edit and the evaluated performance is presented. All the designs, optimizations and
evaluations performed are based on BSIM3 device parameter of TSMC 0.18μm CMOS technology with
1.8V supply rail at 25°C temperature using S-Edit of Tanner EDA.

Results:
The reliability was investigated of the proposed 4-b×4-b multiplier in the temperature range -
40°C to 100°C for maximum PDP variation.

Conclusion:
A benchmarking analysis in terms of speed-power performance with recent competitive
design reveals preeminence of the proposed technique.
The Quantum Cost Optimized Design of 2:4 Decoder Using the New Reversible Logic Block
Authors: Maity Heranmoy , Biswas Arindam , Bhattacharjee Arup K. , Pal Anita 
Published: September 2019

Aim and Objective:
This paper presents the quantum cost, garbage output, constant input
and number of reversible gate optimized 2:4 decoder using 4×4 new reversible logic gate which is
named as reversible decoder block or RD block.

Method:
The proposed block is implemented with a quantum circuit and quantum cost of the proposed
RD block is 8. The proposed decoder can be designed using only one new proposed block.

Results and Conclusion:
The quantum cost, garbage output, constant input and gate number of the
proposed 2:4 decoder is 9, 0, 2 and 1 which is better w.r.t previously reported work. The improvement
% of quantum cost, garbage output, constant input and number of gates are 12.5 – 77.148 %, 100 %,
33.33 – 75 % and 0 – 85.71%.
“Being a Woman” in the Shadow of Vaginismus: The Implications of Vaginismus for Women
Authors: Deliktas Demirci Ayse , Kabukcuoglu Kamile 
Published: September 2019

Introduction:
Vaginismus includes some psychological conditions such as fear of pain
and avoidance from penetration. There is little knowledge about the effects of vaginismus.

Objective:
The present study aims to present the bio-psychosocial consequences of vaginismus in
women life.

Methods:
The method of the present study is a review, which is conducted on the available resources.
All relevant studies were included to present effects of vaginismus on the women.

Results:
Women who have vaginismus have many problems with self-identity, psychological and
reproductive lives. Most of the effects of vaginismus lead to another deep effect on women. Women
with vaginismus mostly describe themselves negatively. This negative self-perception affects
women’s self-esteem levels which cause psychiatric disorders. The psychiatric disorders have been
associated with vaginismus as a reason and result. It is stated in the studies that the general anxiety
and, penetration specific anxiety are related to vaginismus. This result reflects that women with
vaginismus have more anxiety about penetration. Women with vaginismus encounter reproductive
problems, who are more likely to encounter increased cesarean section and fertility problems, they
are reluctant to seek health care services, especially due to fear of the gynaecological examination.

Conclusion:
Although vaginismus is a common problem, there is little information about the effects
of vaginismus on women. Vaginismus causes psychiatric disorders and reproductive problems. The
researchers should examine how women live with vaginismus. It is also suggested that psychotherapy
techniques should include couples interventions and, researchers should examine psychological
health of women deeply.
The Relation between Preserved Social Support, Resilience (Depression and Anxiety) and Psychiatric Disorders among a Sample of Egyptian Patients on Regular Hemodialysis
Authors: Abd Al-Maksoud Ayman Al-Hosainey , Salama Al-Adl Ahmed , Fathi Asla Amir , Bahbah Eshak I. , Emad Doaa , Mokhtar Amal , Attia Mahmoud Mohamed 
Published: September 2019

Background:
Patients on hemodialysis are at a high risk of psychiatric disorders as they
face an emotional challenge in addition to physical impairment.

Objective:
This study aims to assess the prevalence of depression and anxiety among a sample of
patients with end-stage renal disease on regular dialysis, and the effect of resilience and social support
on them.

Methods:
This cross-sectional study was conducted on 45 patients who had been on hemodialysis
for the past three months. Anxiety and depression were assessed with a clinical interview. The severity
of depression, perceived social support, and resilience were assessed using the Beck Depression
Inventory (BDI), Multi-dimensional Scale of Perceived Social Support (MSPSS), and Resilience
Scale, respectively.

Result:
The mean age of enrolled patients was 49.2 ± 14.0 years, and the mean duration of hemodialysis
was 4.5 ± 3.8 years. The prevalence of depression was 24.4% and that of anxiety was 20%.
According to our analysis, 15 (33.3%) patients were diagnosed with minor depression, 6 (13.3%)
with mild depression, 14 (31.1%) with moderate depression, and 10 (22.2%) with severe depression.
Resilience correlated significantly with a psychiatric diagnosis (p=0.004). Perceived social support
was also found to be significantly correlated with a psychiatric diagnosis (p=0.012).

Conclusion:
Depression and anxiety are common mental disorders in patients with CKD and are
considered as the main determinants of quality of life and death rate. Increasing awareness, early
evaluation, and management of depression and anxiety may improve the functional, social, and
clinical outcomes of the patients with CKD.
Implementing Digital Storytelling for Health-Related Outcomes in Older Adults: Protocol for a Systematic Review
Authors: Stargatt Jennifer , Bhar Sunil , Bhowmik Jahar , Al Mahmud Abdullah 
Published: September 2019

Background
The number of older adults is increasing rapidly worldwide. Older adults face a unique set of challenges and may experience a range of psychological comorbidities. Advances in multimedia technology have allowed for digital storytelling to be utilized as an intervention for health-related outcomes.

Objective
The primary aim of the proposed systematic review is to examine the reported health-related outcomes for older adults engaged in digital storytelling. The review also aims to examine the methods associated with digital storytelling, characteristics of digital story products, and implementational considerations.

Methods
This protocol adheres to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols. We will systematically search selected electronic databases to identify studies that meet our eligibility criteria. From the included studies, data will be extracted and synthesized using a narrative approach and summarized in tables. The methodological quality of the included studies will be assessed using the Mixed Methods Appraisal Tool.

Results
Systematic searches, data extraction and analysis, and writing of the systematic review are expected to be completed by the end of 2019.

Conclusions
The proposed systematic review will summarize the existing studies using digital storytelling to improve health-related outcomes for older adults. Results from this review will provide an evidence base for the development of digital storytelling interventions that are effective and implementable with older adults.

International Registered Report Identifier (IRRID)
PRR1-10.2196/15512
OPTIMIZATION AND CHARACTERIZATION OF PEG-PCL-PEG TRIBLOCK COPOLYMER AS CARRIER OF DRUG USING FULL FACTORIAL DESIGN
Authors: ZYNOPSICHA ARMATAZAKA  , T. N. SAIFULLAH SULAIMAN  , ZULKARNAIN ABDUL KARIM 
Published: September 2019

Objective: Triblock copolymer of poly(ethylene glycol)-poly(ɛ-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) was applicated as hydrophobic drug. This study aims to optimization and characterization of PECE triblock copolymer as carriers of hydrophobic drug (ketoprofen).
Methods: Triblock copolymer of PECE was prepared with varying composition ratio of PEG and PCL by ring-opening and coupling reaction. The characteristics of triblock copolymer were characterized using FTIR and DSC. Variation composition ratio of poly(ɛ-caprolactone) (PCL)/poly(ethylene glycol) (PEG) and ratio PECE/drug as factors for optimization using full factorial design. Ketoprofen was loaded into PECE triblock copolymer micelles by emulsification and solvent evaporation method. Responses were measured particle size, entrapment efficiency (EE) and drug solubility.
Results: The result of this study showed that a higher ratio of PCL/PEG and ratio of PECE/drug, reducing particle size, increasing EE and improving drug solubility. The optimum formula obtained by ratio of PCL/PEG is 2:1 and ratio of PECE/drug is 40:1 with particle size is 356,967±9,142 nm, EE is 57,751±0,437%, drug solubility is 32,648±0,200 µg/ml and zeta potential-18,867±2,578 mV. A full factorial design was applied to determine the optimum formula for the PECE triblock copolymer as drug carriers.
Conclusion: The PECE triblock copolymer was preparated using ring-opening polymerization method with Sn(Oct)2 as a catalyst and then continued the reaction with HMDI as coupling agent. Ketoprofen was loaded into PECE triblock copolymer using methods emulsification and solvent evaporation.
Création d’espaces relationnels dans le web documentaire
Authors: Tassé Gilles 
Published: September 2019

Context Web documentaries are relatively new media and documentary entities and, though some articles have been written about them and typologies of the genre have been developed, no one has yet underlined or discussed their capacities for creating relational spaces, namely spaces that facilitate individual and group relationships, and social and individual links. Analysis This article examines, from a relational perspective, a selection of webdocumentaries produced primarily by the National Film Board of Canada (NFB), in a desire to identify the address modalities and interactive devices specific to this media object, that foster conversation, sharing, a sense of identification, collaboration and the discovery of others. Conclusions and implications Webdocumentaries, through their spaces of expression, communication and collaboration, support a feeling of listening and of being heard. They act as a public place that encourages the meeting of others and asynchronous socialization.
Crisis or Transformation? Debates over Journalistic Work in Canada
Authors: Wilkinson Sabrina , Winseck Dwayne 
Published: September 2019

Background There is a broad recognition that journalism is facing difficult times in Canada and internationally.Analysis This article reviews the literature on the state of journalism and then focuses on one element of the perceived crisis of journalism in the Canadian context: claims that the number of employed journalists has fallen sharply in recent years. Using data from Statistics Canada and the United States Bureau of Labor Statistics, the authors find that, unlike the United States, the number of journalists employed in Canada has risen slightly in absolute terms over the past two decades.Conclusions and implications These findings have important implications for how researchers, politicians and the public think about the state of journalism in Canada and what types of policy prescriptions might be more or less appropriate to deal with the real but not necessarily calamitous changes that are taking place.
Classification as Catachresis: Double Binds of Representing Difference with Semiotic Infrastructure
Authors: Poirier Lindsay 
Published: September 2019

Background This article explores the results of a three-year ethnographic study of how semiotic infrastructures—or digital standards and frameworks such as taxonomies, schemas, and ontologies that encode the meaning of data—are designed. Analysis It examines debates over best practices in semiotic infrastructure design, such as how much complexity adopted languages should characterize versus how restrictive they should be. It also discusses political and pragmatic considerations that impact what and how information is represented in an information system. Conclusion and implications This article suggests that all databased representations are forms of data power, and that examining semiotic infrastructure design provides insight into how culturally informed conceptions of difference structure how we access knowledge about our social and material worlds.
TINGKAT KEBERHASILAN SAMBUNGAN DAN PERTUMBUHAN BIBIT KOPI ROBUSTA (COFFEA ROBUSTA L.) HASIL GRAFTING PADA PEMBERIAN BERBAGAI JENIS MIKORIZA DAN KETINGGIAN BATANG BAWAH
Authors: Kartika Elis 
Published: September 2019

Tujuan penelitian ini adalah untuk mendapatkan jenis mikoriza dan ketinggian batang bawah yang mampu meningkatkan keberhasilan sambungan sertapertumbuhan dan serapan P bibit kopi robustahasil grafting. Percobaan ini merupakan percobaan faktorial dua faktor menggunakan Rancangan Acak Lengkap tiga ulangan. Faktor pertama adalah inokulasi mikoriza yang terdiri dari enam taraf yaitu tanpa inokulasi mikoriza, inokulasiGlomus sp-3, Glomus sp-6, Glomus sp-15, Glomus sp-16, sertagabungan Glomus sp-3, sp-6, sp-15, sp-16. Faktor kedua berupa ketinggian batang bawah yang terdiri atas lima taraf yaitu ketinggian batang bawah 5, 10, 15, 20dan 25 cm dari pangkal akar.Hasil penelitianmenunjukkan bahwa pertumbuhan dan serapan P bibit kopi robusta hasil grafting terbaik pada berbagai jenis mikoriza diperoleh pada ketinggian batang bawah 15 cm dari pengkal akar. Pertumbuhan dan serapan P bibit kopi robusta hasil grafting pada berbagai ketinggian batang bawah diperoleh pada jenis mikoriza gabungan Glomus sp-3, sp-6, sp-15, sp-16. Tingkat keberhasilan penyambungan bibit kopi robusta bermikoriza adalah 100% dan bibit yang tidak bermikoriza sebesar 79.87 %, sedangkan pada berbagai ketinggian batang bawah berkisar anatar 95.83 sampai 97.22 %.
Participação das mulheres na graduação da Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul
Authors: Baldissera Renata Dos Santos , Grecca Fabiana Soares , Dos Santos Régis Burmeister 
Published: September 2019

Em 1866, na Universidade de Ohio, graduou-se a primeira mulher da história da Odontologia, sendo que a inserção da mulher na Odontologia ocorreu de forma lenta e gradual, acompanhando o desenvolvimento histórico e cultural da sociedade. Um dos fatores que faz com que a mulher opte pela carreira odontológica é o fato de poder exercer o trabalho de forma autônoma. O obejtivo desse trabalho foi avaliar o crescimento da participação da mulher na Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul (FO-UFRGS).Foram analisados os documentos que continham todos os formandos da FO – UFRGS do período de 1900-2008. Foi verificado que em 1904, graduaram-se as três primeiras estudantes femininas. No inicio da década de 60, verificou-se um aumento crescente na participação da mulher atingindo taxa de 45%. No ano de 2008 a taxa chegou a 64% de mulheres. Atualmente, as mulheres constituem 68% dos acadêmicos da Faculdade.Podemos concluir que a mulher iniciou cedo sua participação na Odontologia gaúcha. Deste período até os nossos dias tem havido um paulatino aumento desta participação, culminando com o seu predomínio numérico em relação ao sexo masculino.
Palavras chave: odontologia, trabalho feminino, mulher.
Heterocontrole da Fluoretação da Água de Abastecimento Público do Município de Cachoeira do Sul – RS
Authors: PIVA Fabiane , TOVO Maximiano Ferreira , KRAMER Paulo Floriani 
Published: September 2019

A fluoretação da água de abastecimento público tem sido considerada como um método econômico e de grande abrangência populacional para o controle da doença cárie. Entretanto, a efetividade desse método depende da manutenção de níveis adequados de fluoretos e da continuidade da implantação dessa medida. Este estudo teve como objetivo avaliar a concentração de flúor presente na água de abastecimento do município de Cachoeira do Sul –RS, por um período de 12 meses. As amostras foram
coletadas mensalmente em 8 diferentes pontos da cidade, os quais representavam a população abastecida, e também na estação de tratamento (ETA). O método utilizado na análise das amostras foi o Eletrométrico, eletrodo íon-específico, sendo que a cada avaliação o aparelho foi calibrado.
Os resultados demonstraram que houve uma oscilação na concentração de flúor que variou de 0,40 a 1,00 ppmF/L durante o período avaliado. A média da concentração de flúor entre todas as amostras foi 0,66 ppmF/L e a mediana foi 0,68 ppmF/L. Das 104 amostras coletadas, 66 (63,4%)apresentaram a concentração de flúor adequada (entre 0,6
e 0,9 ppmF/L) e 38 (36,6%) apresentaram níveis inadequados. Neste estudo podemos concluir que houve uma oscilação do teor de fluoretos na água de abastecimento do município de Cachoeira do Sul, o que pode interferir nos benefícios esperados pela fluoretação da água de abastecimento na população estudada.
Avaliação subjetiva de artefatos em tomografias computadorizadas de feixe cônico produzidos pelo MTA Fillapex e AH Plus
Authors: Guimarães Carolina Dos Santos , Pontual Andrea Dos Anjos , Melo Jr. Paulo Mauricio Reis de , Cruz Michelle Lopes Ramos , Silveira Márcia Maria Fonseca da 
Published: September 2019

Introdução: O objetivo deste trabalho foi analisar subjetivamente através de um questionário se a radiopacidade dos cimentos endodônticos MTA Fillapex e AH Plus é capaz de produzir artefatos em tomografias computadorizadas de feixe cônico, interferindo na qualidade da imagem e prejudicando o diagnóstico.
Métodos: Para tanto, foram formados 1 grupo controle contendo 14 dentes hígidos sem qualquer tratamento endodôntico e 3 grupos experimentais denominados de grupo 1,2 e 3. O grupo 1 conteve 10 dentes testes obturados apenas com guta percha sem cimento endodôntico. O grupo 2 conteve 10 dentes obturados com guta percha embebidas em MTA Fillapex e o grupo 3 apresentou 10 dentes obturados com guta percha associada ao AH Plus. Os grupos foram expostos em um tomógrafo de feixe cônico iCAT a 120Kvp, 37,07mAs, voxel de 0,125mm e tempo de aquisição de 26,9s. As imagens foram salvas em formato xstd e analisadas através do programa XoranCAT por um avaliador especialista em radiologia e endodontia. A avaliação foi feita através de um questionário com perguntas objetivas sobre presença de artefatos, qualidade de imagem nos terços cervical, médio e apical e possibilidade das imagens auxiliarem no correto diagnóstico dos tecidos dentais radiculares
Resultados: Os resultados mostraram que houve presença de artefatos em todas as aquisições dos grupos experimentais, assim como 100% das imagens dos grupos experimentais não foram satisfatórias para auxiliarem no correto diagnóstico dos tecidos dentais radiculares. O grupo controle não apresentou artefatos, assim como as imagens foram consideradas satisfatórias para o auxílio de um correto diagnóstico.
Conclusões: A tomografia computadorizada de feixe cônico é uma importante ferramenta para o diagnóstico endodôntico. No entanto, assim como outros sistemas de imagens, é passível de falhas. Por este motivo, o diagnóstico clínico sempre deve prevalecer sobre os exames de imagens, sendo estes coadjuvantes no processo para um correto diagnóstico.