bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Influence or Rational Choice? Two Models and Their Contribution to Explaining Class Differentials in Student Educational Aspirations
Authors: Zimmermann Thomas 
Published: October 2019

AbstractBoth the Wisconsin model of status attainment (WIM) and rational choice theory (RCT) indicate that social class differentials in student educational aspirations are partially determined by academic performance. Conditional on performance, the WIM predicts that social influence mechanisms explain the remaining class differentials, whereas RCT maintains that rational calculus factors provide the explanation. Both theories have rarely been compared directly using large-scale empirical data. Moreover, the appropriateness of these models has been questioned for highly stratified and selective educational systems such as Germany’s. In this article, we analyse the extent to which the WIM and RCT can explain the relationship between students’ social class origins and their educational aspirations. We use data from the National Educational Panel Study and analysed the aspirations of 4,896 ninth-graders in German schools along with data about their school performance, social class positions, social influences, and rational choice factors. Our mixed logit models largely confirm that both social influences and rational choice factors mediate class differentials. Five factors contribute the most: parents’ expectations, friends’ aspirations, the motive of status maintenance, costs, and perceived probability of success. This research confirms that both the WIM and RCT can each independently explain aspirations and class differentials in aspirations.
Changes in tobacco-related morbidity and mortality in French women: worrying trends
Authors: Olié Valérie , Pasquereau Anne , Assogba Frank A G , Arwidson Pierre , Nguyen-Thanh Viet , Chatignoux Edouard , Gabet Amélie , Delmas Marie-Christine , Bonaldi Christophe 
Published: October 2019

Abstract

Background
The high prevalence of smoking among French women since the 1970s has been reflected over the past decade by a strong impact on the health of women. This paper describes age and gender differences in France of the impact of smoking on morbidity and mortality trends since the 2000s.

Methods
Smoking prevalence trends were based on estimates from national surveys from 1974 to 2017. Lung cancer incidence were estimated from 2002–12 cancer registry data. Morbidity data for chronic obstructive pulmonary disease (COPD) exacerbation and myocardial infarction were assessed through hospital admissions data, 2002–15. For each disease, number of deaths between 2000 and 2014 came from the national database on medical causes of death. The tobacco-attributable mortality (all causes) was obtained using a population-attributable fraction methodology.

Results
The incidence of lung cancer and COPD increased by 72% and 100%, respectively, among women between 2002 and 2015. For myocardial infarction before the age of 65, the incidence increased by 50% between 2002 and 2015 in women vs. 16% in men and the highest increase was observed in women of 45–64-year-olds. Mortality from lung cancer and COPD increased by 71% and 3%, respectively, among women. The estimated number of women who died as a result of smoking has more than doubled between 2000 and 2014 (7% vs. 3% of all deaths).

Conclusions
The increase in the prevalence of smoking among women has a major impact on the morbidity and mortality of tobacco-related diseases in women and will continue to increase for a number of years.
Is there an association between socioeconomic status of General Practice population and postgraduate training practice accreditation? A cross-sectional analysis of Scottish General Practices
Authors: McCallum Marianne , Hanlon Peter , Mair Frances S , Mckay John 
Published: October 2019

Abstract

Background
Practice population socioeconomic status is associated with practice postgraduate training accreditation. General Practitioner recruitment to socioeconomically deprived areas is challenging, exposure during training may encourage recruitment.

Objectives
To determine the association of practice population socioeconomic deprivation score and training status, and if this has changed over time.

Methods
Cross-sectional study looking at socioeconomic deprivation and training status for all General Practices in Scotland (n = 982). Data from Information Services Division, from 2015, were combined with the Scottish Index of Multiple Deprivation to calculate weighted socioeconomic deprivation scores for every practice in Scotland. Scottish training body database identified training practices (n = 330). Mean deprivation score for training and non-training practices was calculated. Logistic regression was used to quantify the odds ratio of training status based on deprivation score, adjusted for practice list size, and compared with a similar 2009 analysis.

Results
Socioeconomic deprivation score is associated with training status, but is not significant when adjusted for practice list size [OR (adjusted) 0.87, 95% CI: 0.74–1.04]. In contrast, in 2009, adjusted deprivation score remained significant. Mean deprivation score in training and non-training practices remained similar at both time points [2015: 2.98 (SD 0.88) versus 3.17 (SD 0.81); 2009: 2.95 versus 3.19), with a more deprived mean score in non-training practices.

Conclusions
General practices in affluent areas remain more likely to train, although this association appears to be related to larger practice list sizes rather than socioeconomic factors. To ensure a variety of training environments training bodies should target, and support, smaller practices working in more socioeconomically deprived areas.
Utilization of different dissolved organic phosphorus sources by Symbiodinium voratum in vitro
Authors: Tian-Tian Liu , Ping Huang , Jia-Xing Liu , Zhi-Xin Ke , Ye-Hui Tan 
Published: October 2019

ABSTRACTThis study examines the physiological responses of the Symbiodiniumvoratum (clade E) to two types of phosphates having different chemical bonds—phosphoesters (C-O-P bonds) and phosphonates (C-P bonds) to explore Symbiodinium cell growth and the molecular perspective of the P utilization process. Alkaline phosphatase (AP), PhnX, PhoA and PhoX expression was profiled for different P conditions using the RT-qPCR method. In a sterile system, Symbiodinium could decompose phosphoesters, such as ATP and glucose 6-phosphate (G-6-P), into dissolved inorganic P (DIP) to supplement inorganic phosphorus but could not directly use phosphoesters for growth. The growth rate and photosynthetic efficiency of zooxanthellae in phosphoester-containing media did not significantly differ from those in the DIP group but were significantly inhibited in medium containing phosphonates such as N-(phosphonomethyl)glycine (glyphosate) and 2-aminoethylphosphonic acid (2-AEP), as well as in DIP-poor medium. The phosphonate group DIP concentration did not change remarkably, indicating that phosphonates can neither be directly used by zooxanthellae nor decomposed into DIP. Our RT-qPCR results support our views that the phosphoesters (C-O-P) had been hydrolyzed outside the cell before being absorbed into the Symbiodinium cell, and implies that PhnX, PhoA and PhoX are perhaps responsible for transporting DIP from medium into cells and for storage of DIP.
Carbohydrate active enzymes are affected by diet transition from milk to solid food in infant gut microbiota
Authors: Ye Lingqun , Das Promi , Li Peishun , Ji Boyang , Nielsen Jens 
Published: October 2019

ABSTRACT
Infants experience a dramatic change in their food in the first year after birth when they shift from breast milk to solid food. This results in a large change in presence of indigestible polysaccharides, a primary energy resource of gut microbes. How the gut microbiota adapts to this dietary shift has not been well examined. Here, by using metagenomics data, we studied carbohydrate-active enzymes (CAZymes) of gut microbiota, which are essential enzymes catalyzing the breakdown of polysaccharides, during this dietary shift. We developed a new approach to categorize CAZyme families by food intake and found CAZyme families associated with milk or solid food. We also found CAZymes with most abundance in 12 months infants that are not associated with solid food or milk but may be related to modulating carbohydrates in the mucus. Additionally, the abundance of gut CAZymes were found to be affected by many other factors, including delivery modes and life style in adults. Taken together, our findings provide novel insights into the dynamic change of gut CAZymes in early human life and provide potential markers for food interference or gut microbiota restoration.
Biogenic silver nanoparticles as a more efficient contrivance for wound healing acceleration than common antiseptic medicine
Authors: Giri Ved Prakash , Pandey Shipra , Kumari Madhuree , Paswan Shravan Kumar , Tripathi Ashutosh , Srivastava Manjoosha , Rao Chandana Venketswara , Katiyar Ratna , Nautiyal Chandra Shekhar , Mishra Aradhana 
Published: October 2019

ABSTRACTA simple and facile way of using biogenic silver nanoparticles (BSNP) (10–20 nm) was developed for wound healing acceleration and suppression of wound infections. The BSNP were formulated in an ointment base, and the study to accelerate the wound healing process was conducted in a rat. The pH of the BSNP ointment, pH 6.8 ± 0.5, lies in normal pH range of the human skin, with good spreadability and diffusibility. The wound closure rate, as a percentage, was highest at day 3 for a BSNP ointment-treated wound at 22.77 ± 1.60%, while in an untreated control the rate was 10.99 ± 1.74%, for Betadine 14.73 ± 2.36% and for Soframycin 18.55 ± 1.37%, compared with day 0. A similar pattern of wound closure rate was found at days 7 and 11. The antibacterial activity of BSNP was evaluated against wound-infection-causing bacteria Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli by the agar diffusion method. The total bacterial counts in the wound area were enumerated by the colony forming unit method. The lowest number of bacterial counts was found in the BSNP-treated wound compared with the other groups. BSNP treatment at 7.5% concentration enhanced migration of fibroblasts in a scratch assay. These findings reveal BSNP as an efficient contrivance for wound healing acceleration and as an eco-friendly alternative therapeutic antimicrobial agent.
Impact of sequelae of visceral leishmaniasis and their contribution to ongoing transmission of Leishmania donovani
Authors: Duthie Malcolm S , Goto Yasuyuki , Ghosh Prakash , Mondal Dinesh 
Published: October 2019

ABSTRACT
Visceral leishmaniasis (VL) in the Old World is caused by infection with Leishmania donovani. Although the numbers of new reported cases of VL in Africa have been relatively stable for several years, the low numbers currently reported on the Indian subcontinent suggest a positive impact of new treatments and intervention strategies. In both regions, however, VL relapse and post-kala-azar dermal leishmaniasis (PKDL) maintain infectious reservoirs and therefore present a threat to control programs. In this review, we outline the evolving appreciation of PKDL as an impactful disease in its own right and discuss the various diagnostic methods that can be applied for the detection and characterization of PKDL cases. We also highlight the data that indicate the potential, and likely contribution, of PKDL cases to ongoing transmission of L. donovani.
Transition in Older Parent–Adult Child Relations in U.S. Chinese Immigrant Families
Authors: Guo Man , Stensland Meredith , Li Mengting , Beck Todd , Dong Xinqi 
Published: October 2019

Abstract

Background and Objectives
The family fundamentally underpins the immigration and acculturation processes. But most existing research on acculturation focuses on individual instead of family experience. Guided by Berry’s acculturation theory and Intergenerational Solidarity Theory, this study examined continuity and changes in parent–adult child relations of older Chinese immigrants over a 2-year period, and their implications for older adults’ depression and quality of life (QoL).

Research Design and Methods
Participants included 2,605 older Chinese immigrants from the Population Study of Chinese Elderly in Chicago (PINE). Latent Transition Analysis (LTA) was used to identify transitions in multidimensional parent–child relations over time. Negative binomial and logistic regressions were used to examine the influence of family transitions on depression and QoL, respectively.

Results
LTA revealed five types of family relations: traditional, modified traditional, coresiding-unobligated, independent, and detached. Over 40% of the respondents shifted to a different relation type, with more families classified as modified traditional or independent over time. Transitioning into modified traditional relations or out of detached relations was associated with fewer depressive symptoms and better QoL at the follow-up. Transitioning into independent relation was associated with more depressive symptoms over time.

Discussion and Implications
Parent–child relations among Chinese older immigrants demonstrate significant complexity, including both heterogeneity and fluidity. Better well-being of these older adults seems to stem from the optimal combination of retaining the supportive heritage culture and embracing the host society’s instrumental cultural elements. Services to this population need to include the family context in assessment and interventions.
Are People Ready for Personalized Brain Health? Perspectives of Research Participants in the Lifebrain Consortium
Authors: Friedman Barbara Bodorkos , Suri Sana , Solé-Padullés Cristina , Düzel Sandra , Drevon Christian A , Baaré William F C , Bartrés-Faz David , Fjell Anders M , Johansen-Berg Heidi , Madsen Kathrine S , Nyberg Lars , Penninx Brenda W J H , Sexton Claire , Walhovd Kristine B , Zsoldos Enikő , Budin-Ljøsne Isabelle 
Published: October 2019

Abstract

Background and Objectives
A healthy brain is central to physical and mental well-being. In this multi-site, qualitative study, we investigated views and attitudes of adult participants in brain research studies on the brain and personalized brain health as well as interest in maintaining a healthy brain.

Design and Methods
We conducted individual interviews with 44 adult participants in brain research cohorts of the Lifebrain consortium in Spain, Norway, Germany, and the United Kingdom. The interviews were audio recorded, transcribed, and coded using a cross-country codebook. The interview data were analyzed using qualitative content analysis.

Results
Most participants did not focus on their own brain health and expressed uncertainty regarding how to maintain it. Those actively focusing on brain health often picked one specific strategy like diet or memory training. The participants were interested in taking brain health tests to learn about their individual risk of developing brain diseases, and were willing to take measures to maintain their brain health if personalized follow-up was provided and the measures had proven impact. The participants were interested in more information on brain health. No differences in responses were identified between age groups, sex, or countries.

Discussion and Implications
Concise, practical, personalized, and evidence-based information about the brain may promote brain health. Based on our findings, we have launched an ongoing global brain health survey to acquire more extensive, quantitative, and representative data on public perception of personalized brain health.
Mutations in CHCHD2 cause α-synuclein aggregation
Authors: Ikeda Aya , Nishioka Kenya , Meng Hongrui , Takanashi Masashi , Hasegawa Iwao , Inoshita Tsuyoshi , Shiba-Fukushima Kahori , Li Yuanzhe , Yoshino Hiroyo , Mori Akio , Okuzumi Ayami , Yamaguchi Akihiro , Nonaka Risa , Izawa Nana , Ishikawa Kei-ichi , Saiki Hidemoto , Morita Masayo , Hasegawa Masato , Hasegawa Kazuko , Elahi Montasir , Funayama Manabu , Okano Hideyuki , Akamatsu Wado , Imai Yuzuru , Hattori Nobutaka 
Published: October 2019

Abstract
Mutations in CHCHD2 are linked to a familial, autosomal dominant form of Parkinson’s disease (PD). The gene product may regulate mitochondrial respiratory function. However, whether mitochondrial dysfunction induced by CHCHD2 mutations further yields α-synuclein pathology is unclear. Here, we provide compelling genetic evidence that mitochondrial dysfunction induced by PD-linked CHCHD2 T61I mutation promotes α-synuclein aggregation using brain autopsy, induced pluripotent stem cells (iPSCs) and Drosophila genetics. An autopsy of an individual with CHCHD2 T61I revealed widespread Lewy pathology with both amyloid plaques and neurofibrillary tangles that appeared in the brain stem, limbic regions and neocortex. A prominent accumulation of sarkosyl-insoluble α-synuclein aggregates, the extent of which was comparable to that of a case with α-synuclein (SNCA) duplication, was observed in CHCHD2 T61I brain tissue. The prion-like activity and morphology of α-synuclein fibrils from the CHCHD2 T61I brain tissue were similar to those of fibrils from SNCA duplication and sporadic PD brain tissues. α-Synuclein insolubilization was reproduced in dopaminergic neuron cultures from CHCHD2 T61I iPSCs and Drosophila lacking the CHCHD2 ortholog or expressing the human CHCHD2 T61I. Moreover, the combination of ectopic α-synuclein expression and CHCHD2 null or T61I enhanced the toxicity in Drosophila dopaminergic neurons, altering the proteolysis pathways. Furthermore, CHCHD2 T61I lost its mitochondrial localization by α-synuclein in Drosophila. The mislocalization of CHCHD2 T61I was also observed in the patient brain. Our study suggests that CHCHD2 is a significant mitochondrial factor that determines α-synuclein stability in the etiology of PD.
Impact of acute kidney injury on prognosis of chronic kidney disease after aortic arch surgery
Authors: Nakamura Tamami , Mikamo Akihito , Matsuno Yutaro , Fujita Akira , Kurazumi Hiroshi , Suzuki Ryo , Hamano Kimikazu 
Published: October 2019

Abstract

OBJECTIVES
Postoperative acute kidney injury (AKI) is a common complication associated with increased long-term mortality after cardiothoracic surgery. However, AKI after total aortic arch replacement (TAR) is not well studied. This study aimed to investigate the prognosis and impact of AKI on the long-term outcomes of chronic kidney disease (CKD) patients undergoing TAR.

METHODS
We included 208 patients who underwent TAR between September 2003 and December 2014. Patients were divided into a CKD (n = 83, 40%) and non-CKD (n = 125, 60%) group. The definition of AKI followed the Risk, Injury, Failure, Loss of kidney function and End-stage kidney disease (RIFLE) criteria. Independent risk factors for all-cause death and AKI were identified with multivariable analysis.

RESULTS
Postoperative AKI was observed in 24 patients (29%) and 39 patients (31%) of CKD and non-CKD groups, respectively. The survival rate of CKD patients was significantly lower than that of non-CKD patients (P = 0.02). Among CKD patients, the 5-year survival rate was 57% in those with AKI group and 92% in those without AKI; prognosis was significantly poorer in patients with AKI (P = 0.001). In the non-CKD group, there was no difference in prognosis between patients with or without AKI (P = 0.77). Multivariable logistic regression analysis revealed that intraoperative blood loss of ≥600 ml was the only predictor of AKI in the CKD group (odds ratio 4.32, P = 0.04).

CONCLUSIONS
CKD is associated with reduced long-term survival after TAR. Postoperative AKI strongly influences long-term survival in CKD patients only.
Processing Style and Responsiveness to Corrective Information
Authors: Carnahan Dustin , Garrett R Kelly 
Published: October 2019

AbstractThe limited influence of corrective messages is one of the most striking observations in the misperceptions literature. We elaborate on this well-known outcome, showing that correction effectiveness varies according to recipients’ judgment strategy. Using data from two online experiments, we demonstrate that individuals’ responses to corrective messages are less biased by prior attitudes when they engage in on-line rather than memory-based processing. We also show that individuals are more responsive to one-sided messages under conditions of on-line rather than memory-based processing. Unexpectedly, two-sided messages, which repeat the inaccuracy before correcting it, performed better than one-sided messages among individuals using memory-based processes. These findings contribute to our understanding of fact-checking, and suggest strategies that could help promote greater responsiveness to corrective messages.
Row Contractions Annihilated by Interpolating Vanishing Ideals
Authors: Clouâtre Raphaël , Timko Edward J 
Published: October 2019

Abstract
We study similarity classes of commuting row contractions annihilated by what we call higher-order vanishing ideals of interpolating sequences. Our main result exhibits a Jordan-type direct sum decomposition for these row contractions. We illustrate how the family of ideals to which our theorem applies is very rich, especially in several variables. We also give two applications of the main result. First, we obtain a purely operator theoretic characterization of interpolating sequences for the multiplier algebra of the Drury–Arveson space. Second, we classify certain classes of cyclic commuting row contractions up to quasi-similarity in terms of their annihilating ideals. This refines some of our recent work on the topic. We show how this classification is sharp: in general quasi-similarity cannot be improved to similarity. The obstruction to doing so is a scarcity of norm-controlled similarities between commuting tuples of nilpotent matrices, and we investigate this question in detail.
Persistent circulation of a fluoroquinolone-resistant Salmonella enterica Typhi clone in the Indian subcontinent
Authors: Britto Carl D , Dyson Zoe A , Mathias Sitarah , Bosco Ashish , Dougan Gordon , Jose Sanju , Nagaraj Savitha , Holt Kathryn E , Pollard Andrew J 
Published: October 2019

Abstract

Background
The molecular structure of circulating enteric fever pathogens was studied using hospital-based genomic surveillance in a tertiary care referral centre in South India as a first genomic surveillance study, to our knowledge, of blood culture-confirmed enteric fever in the region.

Methods
Blood culture surveillance was conducted at St John’s Medical College Hospital, Bengaluru, between July 2016 and June 2017. The bacterial isolates collected were linked to demographic variables of patients and subjected to WGS. The resulting pathogen genomic data were also globally contextualized to gauge possible phylogeographical patterns.

Results
Hospital-based genomic surveillance for enteric fever in Bengaluru, India, identified 101 Salmonella enterica Typhi and 14 S. Paratyphi A in a 1 year period. Ninety-six percent of isolates displayed non-susceptibility to fluoroquinolones. WGS showed the dominant pathogen was S. Typhi genotype 4.3.1.2 (H58 lineage II). A fluoroquinolone-resistant triple-mutant clone of S. Typhi 4.3.1.2 previously associated with gatifloxacin treatment failure in Nepal was implicated in 18% of enteric fever cases, indicating ongoing inter-regional circulation.

Conclusions
Enteric fever in South India continues to be a major public health issue and is strongly associated with antimicrobial resistance. Robust microbiological surveillance is necessary to direct appropriate treatment and preventive strategies. Of particular concern is the emergence and expansion of the highly fluoroquinolone-resistant triple-mutant S. Typhi clone and its ongoing inter- and intra-country transmission in South Asia, which highlights the need for regional coordination of intervention strategies, including vaccination and longer-term strategies such as improvements to support hygiene and sanitation.