bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ways to increase reliability of work of powerful electrical machines in autonomous electric networks
Authors: Boguslawsky Ilya , Zaboin Valery 
Published: December 2018

The influence of the harmonic composition of the stator current on the permissible power of an electric machine during its operation in an autonomous nonlinear network is considered. A generalizing equation is proposed for calculating this power, taking into account an increase in the electric losses in the stator winding and losses in the steel of the machine. The analysis of the causes of voltage drop at the terminals of an autonomous generator is made and practical recommendations for its reduction are given for an unexpected change in the load of the generator.
The main purpose of investigation is to obtain a generalized expression is derived for calculating the permissible that makes to estimate a reduction of the nominal power of power of alternating current machine when operating in nonlinear networks in condition of knowing harmonics of the stator current. It is usefully for newly created generators and can suppose a changing the operational requirements by the standards for the to the value of transient deviation of the voltage when the load changes suddenly.
Sorption properties of materials based on residual biomass
Authors: Smyatskaya Yulia , Kosheleva Arina , Taranovskaya Elena 
Published: December 2018

In this paper, we consider the possibility of using inexpensive and effective sorption materials based on plant raw materials, such as fruit rind, vegetable waste, fallen leaves, and the use of phytosorbents for the purification of sewage containing heavy metals and petroleum products. The use of vegetable waste for the manufacture of sorbents is a priority for solving environmental problems. It is suggested to use residual biomass as a sorption material, which is formed after extraction of lipids from C. sorokiniana microalgae and duckweed Lemna minor. To increase the sorption capacity, it was proposed to thermally modify the residual biomass. The optimum heat treatment conditions were 450 °C for 20 minutes with limited access to oxygen. The obtained biomass allows one to extract ions of heavy metals with efficiency of 91-93% for ions of lead, cadmium, zinc and copper.
To increase the sorption capacity (A, mg/g) of the residual biomass, heat treated waste from the agro-industrial complex and chitosan were proposed as additives. The addition of chitosan makes it possible to obtain a sorption material in the form of granules, which is convenient to use. For the sorption materials obtained, microstructural studies were carried out, which allowed us to substantiate the sorption properties of the materials. The physical and mechanical properties of sorbents, such as abrasion, grindability, allow us to offer new materials for use on an industrial scale. In the article, a technological scheme for obtaining sorption materials from residual biomass is given.
Motion preservation surgery: excision of juxta C5–C6 intervertebral disc osteoid osteoma using 3D C-arm based navigation: technical report
Authors: Kulkarni Arvind , Patel Ankit 
Published: December 2018

Introduction: Precise targeted excision of the C5–C6 osteoid osteoma with placement of reference array on clavicle with minimal disturbance of anatomy and motion.
Methods: A 20-year-old male presented with an osteoid osteoma in the superior end plate of the C6 vertebra abutting the spinal canal causing intractable pain. The authors curetted the nidus using a 3D C-arm-based intraoperative scan integrated with an optical navigation system through a minimal access anterior cervical exposure. The patient reference array was affixed to the left clavicle using a threaded pin.
Results: The postoperative CT-scan revealed complete excision. Follow-up MRI and CT after 12 months revealed C5–C6 intervertebral disc to be intact without evidence of any tumor recurrence. VAS for neck pain improved from 8/10 to 2/10 immediately postoperatively and 0/10 at 1 year follow-up with no limitation of cervical movement. A motion segment was preserved with this technique.
Conclusions: Navigation allowed safe curettage of the nidus with minimal disturbance to the anatomy and motion. The site of attachment of patient reference array on clavicle can be recommended as stable, meeting all the criteria for optimal accuracy and stability.
Akne-Triade als paradoxe Reaktion auf Therapie mit dem IL-6-Inhibitor Tocilizumab
Authors: Troyanova-Slavkova S. , Rühmer P. , Pötzsch S. , Kowalzick L. 
Published: December 2018

ZusammenfassungAls Akne-Triade bezeichnet man eine Kombination aus Acne conglobata und intertriginöser Akne axillär (sog. Hidradenitis suppurativa) und inguinal/genitoanal. Eine Perifolliculitis capitis abscedens et suffodiens und/oder Steißbeinfisteln (Akne-Tetrade) können hinzutreten. Es handelt sich dabei um eine schwere, chronisch-rezidivierende, furunkuloide und hochentzündliche Form der Akne mit Haut und Subkutis betreffender abszedierender, fistelnder und vernarbender Entzündung, ausgehend von der Haarbalg-Talgdrüsen-Einheit. Das Biologikum Tocilizumab (Handelsnamen RoActemra®) ist ein humanisierter, monoklonaler Antikörper gegen den Interleukin-6 (IL-6)-Rezeptor zur Behandlung der rheumatoiden Arthritis (RA) und der schwersten Form des kindlichen Rheumas, der systemischen juvenilen idiopathischen Arthritis (sJIA; Syn. Morbus Still). Interleukin-6 ist ein Zytokin, das im menschlichen Körper Entzündungsreaktionen moduliert. Hier beschreiben wir den Fall eines 17-jährigen Patienten, der unter der Therapie mit Tocilizumab die schwerste Form einer Akne-Triade als paradoxe Reaktion entwickelte.
Druckverhältnisse bei Verwendung miniaturisierter PNL-Schäfte mit 9,5 Ch bzw. 12 Ch Außendurchmesser für die minimalinvasive perkutane Nephrolitholapaxie (MIP): Ex-vivo-Druckstudien
Authors: Huusmann Stephan , Wolters Mathias , Schilling David , Kruck Stephan , Bader Markus , Tokas Theodoros , Herrmann Thomas , Nagele Udo ,   Training and Research in Urological Surgery and Technology (T.R.U.S.T.)-Group
Published: December 2018

Zusammenfassung
Hintergrund In den letzten Jahren wurde die Entwicklung miniaturisierter Amplatz-Schäfte für die perkutane Nephrolitholapaxie mit dem Ziel eines verringerten Nierentraumas vorangetrieben. Bisherige Studien konnten zwar vergleichbar gute Steinfreiheitsraten im Vergleich zur herkömmlichen PNL bestätigen, jedoch zeigten sich ebenfalls vergleichbare Häufigkeiten postoperativen Fiebers bzw. Septikämien. Als mögliche Ursache hierfür wird der Einfluss der intraoperativen intrapelvinen Drücke aufgrund verwendeter Spülung diskutiert. Ziel der vorliegenden Ex-vivo-Studie war der Vergleich der intrapelvinen Druckverhältnisse unter Verwendung der miniaturisierten 9,5 Ch- bzw. 12 Ch-Amplatz-Schäfte mit dem bereits voruntersuchten 17,5 Ch-MIP M-Schaft.
Material und Methoden Die Schäfte wurden an einem perfundierten Schweinenierenmodell frisch geschlachteter Schweine unter verschiedenen Perfusionsdrücken evaluiert. Der Spüldruck wurde zum einen über eine Spülpumpe (Uromat E.A.S.I. Pumpe, Karl Storz, Tuttlingen, Deutschland) oder per Schwerkraft erzeugt. Über einen transparenchymatös eingebrachten Urodynamikkatheter konnte der intrapelvine Druck kontinuierlich gemessen werden. Es wurden zusätzliche Analysen mit aktiver Flüssigkeitsabsaugung über einen einliegenden Ureterkatheter durchgeführt.
Ergebnisse Der intrapelvine Druck stieg in den Messungen mit moderaten Spüldruckverhältnissen sowohl durch Spülpumpe als auch durch Schwerkraft für beide Schaftgrößen nicht über 40 cmH2O (entsprechend 30 mmHg). Unter Verwendung einer aktiven Flüssigkeitsabsaugung konnten keine bemerkenswerten Druckunterschiede detektiert werden. Bei sehr hohen Spüldrücken konnte sowohl bei Verwendung der Spülpumpe als auch für die Spülung mit Schwerkraft ein deutlicher Anstieg der intrapelvinen Druckverhältnisse unter Verwendung des 9,5 Ch-Schaftes nachgewiesen werden.
Schlussfolgerungen Beide miniaturisierten MIP-Schäfte können mit vergleichbar günstigen Druckeigenschaften wie das etablierte 17,5 Ch-MIP-Set aufwarten. Trotz deutlicher Reduzierung des Schaftdurchmessers bleibt der intrapelvine Druck bei moderaten Spüldrücken unter 40 cmH2O und somit im nicht bedenklichen Bereich.
Endoscopic ultrasound-guided through-the-needle microforceps biopsy in the evaluation of pancreatic cystic lesions: a multicenter study
Authors: Yang Dennis , Samarasena Jason , Jamil Laith , Chang Kenneth , Lee David , Ona Mel , Lo Simon , Gaddam Srinivas , Liu Quin , Draganov Peter 
Published: December 2018

Abstract
Background and study aims Accurate diagnosis and classification of pancreatic cysts (PCs) remains a challenge. The aims of this study were to: (1) evaluate the safety and technical success of a novel microforceps for EUS-guided through-the-needle biopsy (TTNB) of PCs; and (2) assess its diagnostic yield for mucinous PCs when compared to FNA cyst fluid analysis and cytology.
Patients and methods This was a multicenter retrospective analysis of 47 patients who underwent EUS-FNA and TTNB for PCs between January 2014 and June 2017. Technical success was defined as acquisition of a specimen adequate for cytologic or histological evaluation. Cyst fluid carcinoembryonic antigen (CEA) was used to initially categorize cysts as non-mucinous (CEA < 192 ng/mL) or mucinous (CEA ≥ 192 ng/mL). Final diagnosis was based on identifiable mucinous pancreatic cystic epithelium on cytology, microforceps histology and/or surgical histology when available.
Results Forty-seven patients with PCs (mean size 30.7 mm) were included. TTNB was successfully performed in 46 of 47 (97.9 %). Technical success was significantly lower with FNA (48.9 %) compared to TTNB (85.1 %) (P < .001). For cysts with insufficient amount of fluid for CEA (n = 19) or CEA < 192 ng/mL, the cumulative incremental diagnostic yield of a mucinous PC was significantly higher with TTNB vs. FNA (52.6 % vs 18.4 %; P = .004). TTNB alone (34.4 %) diagnosed more mucinous PCs than either CEA ≥ 192 ng/mL alone (6.3 %) or when combined with FNA cytology (9.4 %). One episode of self-limited bleeding (2.1 %) and one of pancreatitis (2.1 %) occurred.
Conclusions EUS-TTNB is safe and effective for evaluating PCs. TTNB may help increase the diagnostic yield of mucinous PCs.
Motivationale Faktoren für die Präferenz der
Fachrichtung Allgemeinmedizin – eine quantitative Untersuchung unter
Medizinstudierenden NRWs für eine zielgerichtete
Nachwuchsgewinnung
Authors: Funkhouser Greta Joan , Ostermann Thomas , Sönnichsen Andreas , Pucher Katharina K. 
Published: December 2018

Zusammenfassung
Ziel der Studie In Anbetracht des prognostizierten
Allgemeinmediziner-Mangels führten wir eine Online-Umfrage unter
allen Medizinstudierenden Nordrhein-Westfalens durch, um Faktoren
für die Entscheidung Medizinstudierender zur Fachrichtung
Allgemeinmedizin (AM) zu identifizieren und die Stärke der
Zusammenhänge zwischen Faktoren und Fachrichtungswahl zu
quantifizieren.
Methodik Um Beweggründe für und gegen die
Fachrichtungswahl AM zu identifizieren wurde eine Faktorenanalyse mit den
Angaben von 3976 Umfrageteilnehmern (22,6% aller eingeladenen
Medizinstudierenden) durchgeführt. Die Stärke der
Zusammenhänge zwischen extrahierten Faktoren und Fachrichtungswahl
wurden mittels Regressionsanalysen für 2862 Teilnehmer ermittelt,
die sich eher für oder gegen AM positioniert hatten. Adjustiert
wurde für relevante Populationsmerkmale.
Ergebnisse Fünf Faktoren wurden identifiziert. Signifikante
Zusammenhänge zur Fachrichtungswahl AM zeigten 4 dieser Faktoren.
„Umfassender Patientenkontakt“ (OR 4,02; 95% KI
[3,5–4,6]), und „flexible Arbeitszeiten“ (OR 1,35;
95% KI [1,2–1,5]) stellen Beweggründe für
die Fachrichtungswahl AM dar, obwohl „höhere(s)
Karrierechancen, Einkommensmöglichkeiten & Ansehen in
anderen Fachrichtungen“ (OR 1,14; 95% KI [1,0–1,3])
gesehen werden. Bessere Möglichkeiten der „Spezialisierung,
Forschung und Teamarbeit in anderen Fachrichtungen“ stehen einer
Wahl von AM als Fach entgegen (OR 0,55; 95% KI
[0,5–0,6]).
Schlussfolgerungen Der Nachwuchsgewinnung dienlich wären die
strukturierte Förderung studentischen Interesses am Patientenkontakt
in Lehrpraxen, mehr Spezialisierung, Forschung und Teamarbeit durch
verbesserte allgemeinmedizinische Strukturen an Universitäten und
eine weitere Flexibilisierung der Arbeitszeiten.
Lhermitte-Duclos Disease with Cervical Arteriovenous Fistula
Authors: Haq Anwar , Alzahrani Ibrahim , Shail Essam , Almubarak Abdulaziz 
Published: December 2018

AbstractLhermitte-Duclos disease is a rare condition with less than 250 cases reported in the literature. It was considered a neoplastic or hamartomatous growth in the cerebellum. It commonly presents with symptoms of high intracranial pressure or obstructive hydrocephalus. Surgical resection is often curative. The lesion is associated with PTEN gene mutation, and it is considered to be one of the diagnostic criteria of Cowden's syndrome. Vascular tumors are reported in this syndrome, including glioblastomas and meningiomas. Furthermore, central nervous system vascular lesions were also reported in Lhermitte-Duclos disease, such as deep venous anomalies and brain arteriovenous fistulas. A report of an asymptomatic spinal cervical AVF in a patient with Lhermitte-Duclos disease was published in 2006. We present the second case of Lhermitte-Duclos disease associated with an asymptomatic spinal cervical AVF in a 17-year-old young woman with literature review of central nervous system vascular lesions in Lhermitte-Duclos disease.
UBTF Mutation Causes Complex Phenotype of Neurodegeneration and Severe Epilepsy in Childhood
Authors: Laššuthová Petra , Štěrbová Katalin , Haberlová Jana , Vyhnálková Emílie , Neupauerová Jana , Staněk David , Šedivá Marie , Kršek Pavel , Seeman Pavel , Sedláčková Lucie 
Published: December 2018

Introduction Neurodegenerative diseases of childhood present with progressive decline in cognitive, social, and motor function and are frequently associated with seizures in different stages of the disease. Here we report a patient with severe progressive neurodegeneration with drug-resistant epilepsy of unknown etiology from the age of 2 years.
Methods and Results Using whole exome sequencing, we found heterozygous missense de novo variant c.628G > A (p.Glu210Lys) in the UBTF gene. This variant was recently described as de novo in 11 patients with similar neurodegeneration characterized by developmental decline initially confined to motor development followed by language regression, appearance of an extrapyramidal movement disorder, and leading to severe intellectual disability. In 3 of the 11 patients described so far, seizures were also present.
Conclusions Our report expands the complex phenotype of neurodegeneration associated with the c.628G > A variant in the UBTF gene and helps to clarify the relation between this one single recurrent pathogenic variant described in this gene to date and its phenotype. The UBTF gene should be considered a novel candidate gene in neurodegeneration with or without epilepsy.
TULA-2 Deficiency Enhances Platelet Functional Responses to CLEC-2 Agonists
Authors: Kostyak John , Mauri Benjamin , Dangelmaier Carol , Patel Akruti , Zhou Yuhang , Eble Johannes , Tsygankov Alexander , McKenzie Steven , Kunapuli Satya 
Published: December 2018

AbstractPlatelet activation is essential for hemostasis. Central to platelet activation are the signals transmitted through surface receptors such as glycoprotein VI, the protease-activated receptors, and C-type lectin-like receptor 2 (CLEC-2). CLEC-2 is a HemITAM (hem-immunoreceptor tyrosine activation motif)-bearing receptor that binds podoplanin and signals through spleen tyrosine kinase (Syk). T-cell ubiquitin ligand-2 (TULA-2) is a protein tyrosine phosphatase that is highly expressed in platelets and targets phosphorylated Y352 of Syk. We wanted to determine whether TULA-2 regulates Syk phosphorylation and activity downstream of CLEC-2. To that end, we used TULA-2 knockout mice and wild-type (WT) littermate controls. We found that TULA-2 deficiency enhances the aggregation and secretion response following stimulation with an excitatory CLEC-2 antibody or the CLEC-2 agonist rhodocytin. Consistently, Syk phosphorylation of Y346 is enhanced, as well as phosphorylation of the downstream signaling molecule PLCγ2, in TULA-2 knockout platelets treated with either CLEC-2 antibody or rhodocytin, compared with WT control platelets. Furthermore, the kinetics of Syk phosphorylation, as well as that of PLCγ2 and SLP-76, is enhanced in TULA-2 knockout platelets treated with 2.5-μg/mL CLEC-2 antibody compared with WT platelets. Similarly, thromboxane production was enhanced, in both amount and kinetics, in TULA-2−/− platelets treated with 2.5-μg/mL CLEC-2 antibody. TULA-2 acts as a negative regulator of CLEC-2 signaling by dephosphorylating Syk on Y346 and restraining subsequent Syk-mediated signaling.
A sexual rejection peptide: potential use for controlling mouse overpopulation
Authors: Osakada Takuya , Itakura Takumi , Kenmochi Ryo , Touhara Kazushige 
Published: December 2018

ABSTRACT
Exocrine gland-secreting peptide 22 (ESP22) is a 10-kDa protein secreted in tears of juvenile mice. ESP22 inhibits sexual behaviors in adults, leading to a reduction in reproduction rate. We herein identified the 24 amino acid sequence within ESP22 that was essential for exhibiting sexual rejection activity. This synthesizable peptide can be useful for controlling mouse overpopulation.
Histones predate the split between bacteria and archaea
Authors: Alva Vikram , Lupas Andrei N 
Published: December 2018

Abstract

Motivation
Histones form octameric complexes called nucleosomes, which organize the genomic DNA of eukaryotes into chromatin. Each nucleosome comprises two copies each of the histones H2A, H2B, H3 and H4, which share a common ancestry. Although histones were initially thought to be a eukaryotic innovation, the subsequent identification of archaeal homologs led to the notion that histones emerged before the divergence of archaea and eukaryotes.

Results
Here, we report the detection and classification of two new groups of histone homologs, which are present in both archaea and bacteria. Proteins in one group consist of two histone subunits welded into single-chain pseudodimers, whereas in the other they resemble eukaryotic core histone subunits and show sequence patterns characteristic of DNA binding. The sequences come from a broad spectrum of deeply-branching lineages, excluding their genesis by horizontal gene transfer. Our results extend the origin of histones to the last universal common ancestor.

Supplementary information
Supplementary data are available at Bioinformatics online.
miRDeep-P2: accurate and fast analysis of the microRNA transcriptome in plants
Authors: Kuang Zheng , Wang Ying , Li Lei , Yang Xiaozeng 
Published: December 2018

Abstract

Motivation
Two major challenges arise when employing next-generation sequencing methods to comprehensively identify microRNAs (miRNAs) in plants: (i) how to minimize the false-positive inheritable to computational predictions and (ii) how to minimize the computational time required for analyzing the miRNA transcriptome in plants with complex and large genomes.

Results
We updated miRDeep-P to miRDeep-P2 (miRDP2) by employing a new filtering strategy and overhauling the algorithm. miRDP2 has been tested against miRNA transcriptomes in plants with increasing genome sizes that included Arabidopsis, rice, tomato, maize and wheat. Compared with miRDeep-P and several other computational tools, miRDP2 processes next-generation sequencing data with superior speed. By incorporating newly updated plant miRNA annotation criteria and developing a new scoring system, the accuracy of miRDP2 outperformed other programs. Taken together, our results demonstrate miRDP2 as a fast and accurate tool for analyzing the miRNA transcriptome in plants.

Availability and implementation
The miRDP2 are freely available from https://sourceforge.net/projects/mirdp2/.

Supplementary information
Supplementary data are available at Bioinformatics online.
The power of participatory story mapping: Advancing equitable development in disadvantaged neighbourhoods
Authors: Lung-Amam Willow S , Dawkins Casey 
Published: December 2018

Abstract
Community developers and planners have long recognized the value of storytelling to engage communities. Yet, in working with disadvantaged communities, they are often challenged to meaningfully engage residents and uncover place values that can help drive community development strategies. In a case study of Langley Park, Maryland, a neighborhood comprised of largely low-income Latino immigrants facing potential displacement from a new transit line, this article investigates the potential of new story mapping techniques and technologies to assist communities in leveraging everyday place meanings and values to advance greater equity in the process of neighborhood redevelopment. It demonstrates how participatory story mapping can empower traditionally marginalized voices and encourage more complex place narratives within community development and planning.
Radiation Risks of Uterine Cancer in Atomic Bomb Survivors: 1958–2009
Authors: Utada Mai , Brenner Alina V , Preston Dale L , Cologne John B , Sakata Ritsu , Sugiyama Hiromi , Sadakane Atsuko , Grant Eric J , Cahoon Elizabeth K , Ozasa Kotaro , Mabuchi Kiyohiko 
Published: December 2018

Abstract

Background
Ionizing radiation is known to be capable of causing cancer of many organs, but its relationship with uterine cancer has not been well characterized.

Methods
We studied incidence of uterine cancer during 1958–2009 among 62 534 female atomic bomb survivors. Using Poisson regression analysis, we fitted excess relative risk (ERR) models to uterine cancer rates adjusted for several lifestyle and reproductive factors. Person-years at risk were also adjusted for the probability of prior hysterectomy, because it could affect the subsequent risk of uterine cancer. We assessed the modifying effect of age and other factors on the radiation risk. For analysis of the modifying effect of age at radiation exposure around menarche, we compared the radiation risk for several exposure-age categories as well as using parametric models.

Results
There were 224 uterine corpus cancers and 982 cervical cancers. We found a significant association between radiation dose and risk of corpus cancer (ERR per Gray [ERR/Gy] = 0.73, 95% confidence interval [CI] = 0.03 to 1.87) but not for cervical cancer (ERR/Gy = 0.00, 95% CI = −0.22 to 0.31). For corpus cancer, we found statistically significant heterogeneity in ERR/Gy by age (Pheterogeneity = .001) with elevated risk for women exposed to radiation between ages 11 and 15 years (ERR/Gy = 4.10, 95% CI = 1.47 to 8.42) and no indication of a radiation effect for exposures before or after this exposure-age range.

Conclusions
The current data suggest that uterine corpus is especially sensitive to the carcinogenic effect of radiation exposure occurring during the mid-pubertal period preceding menarche. There is little evidence for a radiation effect on cervical cancer risk.
External Equity Financing Shocks, Financial Flows, and Asset Prices
Authors: Belo Frederico , Lin Xiaoji , Yang Fan 
Published: December 2018

Abstract
We develop a dynamic model with time variation in external equity financing costs and show that variation in these costs is important for the model to quantitatively capture the joint dynamics of firms’ asset prices, real quantities, and financial flows in the U.S. economy. Growth firms and high investment firms are less risky in equilibrium, because they can substitute more easily debt financing for equity financing when it becomes more costly to raise external equity, which are high marginal utility states. Using a model-implied proxy of aggregate equity issuance cost shocks, we provide empirical support for the model’s economic mechanism.
Received August 7, 2017; editorial decision September 24, 2018 by Editor Stijn Van Nieuwerburgh. Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online