bluuebunny/crossref_metadata_2025_split huggingface dataset:
GAMBARAN TINGKAT PENGETAHUAN KELUARGA TENTANG BAHAYA PEROKOK PASIF DI DUSUN JARANAN PANGGUNGHARJO SEWON BANTUL TAHUN 2015
Authors: Yuliana Fatimah Eka , - Maryana , - Sugeng 
Published: July 2019

The effects of cigarette smoking are not only borne by those who smoke, but also felt by passive smokers. Passive smokers are more inhale of cigarrette smoke with more particles of a substance. The data of Susenas shows the prevalence of passive smokers in Indonesia amounted to 48,9% or 97.560.002 inhabitans, which consist of 31,88% in men and 66% in women. Surveys shows that more than 90% of active smokers have admitted to smoking in home when they were together with other family members.This research aims to know the description of family's level knowledge about the danger of passive smoker in Dusun Jaranan Panggungharjo Sewon Bantul. The research method used was descriptive survey. The research was done in 2015. The research location was in the village of Jaranan, Panggungharjo Sewon Bantul, Yogyakarta. Subjects of this research were members of the family in Jaranan, Panggungharjo, Sewon Bantul who become passieve smokers with productive age (15 – 64 years old) as many as 71 people. This research used proportional random sampling. The research instrument was a questionnaire of 30 statements. Data were analyzed using frequency distribution. In this research showed that 64,7% of respondent were aged over 31 years, 43,6% of respondent had a recent education junior high school,54,92% were housewifes, 93,36% of respondent got the smoke at home, and 64,78% of respondent were inhaled cigarette smoke average <1 hour. From data processing obtained results of the research showed family's level knowledge about the danger of passive smoker was good by 51 respondent (71,8%), qiute as much as 20 respondent (28,2%), and no respondent who had less knowledge level. The description of family's level knowledge about the danger of passive smoker in Dusun Jaranan Panggungharjo Sewon Bantul was in good categories (71,8%). Key word : family, knowledge, the dangers of passive smokers
Effective fertility in direct sowing of spring wheat in the middle Volga region
Authors: Goryanin Oleg Ivanovich , Vasin Alexey Vasilyevich , Shcherbinina Elena Vladimirovna , Dzhangabaev Baurzhan Zhunuzovich , Pronovich Lilia Vladimirovna , Medvedev Ivan Filippovich 
Published: July 2019

It is given the impact of direct sowing technologies with different levels of intensity of arable land use, in comparison with the traditional tillage, on the elements of fertility of ordinary chernozem and productivity of spring durum wheat in the middle Volga region. The complex application of direct sowing technology using straw as fertilizer stabilizes with traditional technology the supply of soil with nitrogen, increases the content of mobile forms of phosphorus in it by 1.5-21.2%, potassium exchange – by 10.4-18.3%. Improving the nitrogen regime of the soil in direct sowing, in which the starting doses of nitrogen fertilizers were combined with integrated plant protection, provided the highest grain yield – 1.76-1.79 t/ha, which is 0.41-0.44 t/ha (30.4-32.6 %) higher than the control. The increase in yield from the use of biological products was 0.15 t / ha (11.9 %), nitrogen fertilizers N30 – 0.17 t/ha (13.4 %), the combined use of fertilizers and insecticides 0.50-0.53 t/ha (39.7-42.0 %). The highest cost recovery was after direct sowing with a maximum level of intensification-1.98-2.02 rubles/ha, which is 0.14-0.32 rubles/ha higher than the other options. The smallest economic indicators obtained in the control to 1.54 rubles/ha. According to the results of research with direct seeding of spring durum wheat in the region is proposed on the background of integrated plant protection application of calculated doses of mineral fertilizers on yield of 2.0 t/ha (pre-sowing, local-band application).
EVALUATION OF THE FUNCTIONAL PROPERTIES OF A BIOLOGICAL CASE FOR IMPLANTABLE CARDIAC DEVICES, IMPREGNATED WITH BIOACTIVE SUBSTANCES IN AN EXPERIMENT ON LARGE LABORATORY ANIMALS
Authors: Artukhina E. A. , Vaskovskiy V. A. , Venediktov A. A. , Evdokimov S. V. , Durmanov S. S. , Evtjushkin I. A. , Bazylev V. V. , Revishvil A. Sh. 
Published: July 2019

Aim. The purpose of the experimental study was to determine the functional properties of the case with antibacterial and hemostatic preparations impregnated on it, to assess the biological safety and the effectiveness of using this medical device in an in vivo model on large laboratory animals (pigs).Material and Methods. The article presents the first results of an experimental study of a domestic extracellular collagen matrix-based biological case “Bio-NEST” for implantable cardiac devices, impregnated with bioactive substances, in an in vivo experiment on large laboratory animals. The experiment was conducted in three chronological stages to analyze and evaluate the safety, efficacy, and histological compatibility of the biological sheath during implantation and reimplantation of cardiac devices using bioactive substances (antibacterial, hemostatic, and their combinations) as well as under the conditions of the established model of infection with pathogenic microflora implant pocket.Results. Results of the study showed that the use of the experimental cover sample was safe for a laboratory animal. Experimental samples were biocompatible and did not cause inflammatory and immune responses. Implantation of cardiac devices in the sample of the case allowed preventing implant migration and development of infectious inflammation of the implant bed when the experimental cover was impregnated with a solution of rifampicin and aminocaproic acid.
EPIDEMIOLOGICAL ASPECTS OF THE PREVALENCE OF CORONARY HEART DISEASE IN AN OPEN URBAN POPULATION: GENDER DIFFERENCES
Authors: Kayumova M. M. , Gakova E. I. , Senatorova O. V. 
Published: July 2019

The aim. To determine gender differences in the prevalence of coronary heart disease in an open urban population.Material and Methods. For a one-stage epidemiological study in an open urban population, a representative sample of 25–64-year-old residents was formed from the electoral lists of the Central Administrative District of Tyumen (n=2000) using a “random” mathematical method. The response rates of the study were 85.0% among men and 70.3% among women. The conclusion about the presence of coronary artery disease was carried out according to strictly standardized epidemiological methods. Definite CHD (strict criteria) and possible CHD (lax criteria) were distinguished based on the extended criteria.Results. The prevalence rates of CHD in the open 25–64-year-old population were 12.4% in men and 10.0% in women. According to strict epidemiological criteria, the prevalence of painless ischemic heart disease prevailed in men; the prevalence of angina pectoris prevailed in women (predominantly at a young age). According to non-strict criteria, possible myocardial ischemia prevailed in men and women.Conclusion. The results can serve as a scientific basis for primary prevention of coronary artery disease and also necessitate identification of the gender differences in the study of the profile of conventional and non-conventional risk factors and their relationships with the prevalence of CHD in an open population of the urbanized Siberian city.
CORONARY ATHEROSCLEROSIS AND CARDIAC ARRHYTHMIAS
Authors: Yaroslavskaya E. I. , Aksenova K. V. 
Published: July 2019

Cardiac arrhythmias are associated with deterioration in patient’s quality of life, thromboembolic complications, and sudden cardiac death. Coronary atherosclerosis is often the cause of cardiac arrhythmias. Myocardial hypoxia and remodeling lead to impaired formation and conduction of the impulse and the development of ectopic rhythm. The article reviews the main pathogenetic mechanisms for various types of cardiac arrhythmias in patients with atherosclerotic coronary lesions.
ASSOCIATION OF LEFT ATRIAL FIBROSIS EXTENT WITH LEFT VENTRICULAR STRUCTURAL AND FUNCTIONAL REMODELLING IN PATIENTS WITH ATRIAL FIBRILLATION
Authors: Gizatulina T. P. , Pavlov A. V. , Martyanova L. U. , Shorokhova I. V. , Kolunin G. V. 
Published: July 2019

Aim.To investigate the relationships between left atrial (LA) fibrosis extent and left ventricular (LV) structural and functional status in patients (pts) with nonvalvular atrial fibrillation (AF).Material and Methods.The study enrolled 56 pts (mean age 57.1±8.4 years, 25 females), admitted to hospital for primary catheter ablation (CA), including 47 pts with paroxysmal AF and 9 pts with persistent AF. All pts had scheduled transthoracic echocardiography to measure size and volume of cardiac chambers and systolic and diastolic functions of the left ventricle. Based on the calculation of the LV mass index (LVMI) and relative wall thickness (RWT), we categorized all pts into 4 groups: (1) normal geometry (n=27); (2) concentric remodeling (normal LVMI and high RWT, n=13); (3) concentric hypertrophy (high LVMI and high RWT, n=6); and (4) eccentric remodeling (high LVMI and normal RWT, n=10). The assessment of LA fibrosis sizes was based on the allocation of low voltage zones (<0.5 mV) in the process of voltage electroanatomic mapping (VEM) as the first stage of CA. Following indicators were calculated: total square of fibrosis (Sf), % of fibrosis from the total LA square (Sf%), the degree of LA fibrosis (an analog of the UTAH score), and number of LA fibrosis zones. Level of NT-proBNP in blood was determined among other laboratory tests. All pts had preserved LV ejection fraction (LVEF).Results.Results of the study confirmed positive relationships between Sf, Sf% and LA diameter, LVMI, and NT-proBNP level. Negative relationship was noted between Sf, Sf%, the UTAH degree and LVEF. Such LV geometry type as eccentric hypertrophy was associated with a higher number of LA fibrosis zones compared to the normal LV geometry, while significant differences in other types of geometry were not found.Conclusion. Thus, LA fibrosis extent was associated with LA size, LV function, and LV geometric remodeling pattern.
CAPABILITIES OF <sup>123</sup>I-MIBG SCINTIGRAPHY AND GATED BLOOD-POOL SPECT IN PREDICTING THE RESULTS OF CARDIAC RESYNCHRONIZATION THERAPY
Authors: Mishkina A. I. , Zavadovsky K. V. , Saushkin V. V. , Lebedev D. I. , Lishmanov Yu. V. , Popov S. V. 
Published: July 2019

Purpose.To assess the diagnostic value of scintigraphy parameters of sympathetic activity and mechanical dyssynchrony of the heart for prediction of the results of cardiac resynchronization therapy (CRT).Material and Methods.The study included 28 patients with functional class III (NYHA) chronic heart failure referred for CRT. Before operation, a set of scintigraphic studies was performed to evaluate mechanical dyssynchrony, the state of cardiac sympathetic innervation, and perfusion. Clinical status, volume indices, and contractility of both cardiac ventricles were evaluated 6 months after CRT. After that, all patients were divided into 2 groups: group 1 included CRT responders (n=15); group 2 comprised non-responders (n=13).Results. Significant differences between groups were found in the following baseline parameters: early heart-to-mediastinum ratio (H/M) (2.42 and 1.87; p<0.05), delayed H/M (1.89 and 1.78; p<0.05), left ventricular (LV) end-diastolic volume (EDV) (271 mL and 299 mL; p<0.05); LV end-systolic volume (ESV) (206 mL and 227 mL; p<0.05), and interventricular dyssynchrony (109 ms and 62 ms; p<0.05). Responders showed a strong correlation between delayed H/M and LV dyssynchrony (–0.795, p<0.05). According to logistic regression analysis, delayed H/M (OR=4.25; 95% CI 1.4–12.92; p<0.5) and interventricular dyssynchrony (OR=1.01; 95% CI 1.003–1.03; p<0.5) were statistically significant determinants of the response to CRT.Conclusion. 123I-MIBG myocardial scintigraphy can be used to predict the effectiveness of CRT. Delayed H/M ratio and interventricular dyssynchrony are the independent predictors of response to CRT.
ACUTE CORONARY SYNDROME WITH NONOBSTRUCTIVE CORONARY ARTERIES: THE SEVERITY OF CORONARY ATHEROSCLEROSIS AND MYOCARDIAL PERFUSION DISORDERS (PILOT STUDY)
Authors: Vorobeva D. A. , Mochula A. V. , Baev A. E. , Ryabov V. V. 
Published: July 2019

Aim. To study the structural and functional status of coronary blood flow in patients with acute coronary syndrome with nonobstructive coronary arteries using multispiral computed tomography (MSCT) and single photon emission tomography (SPECT) and to compare data of MSCT and invasive coronary angiography (ICA).Material and Methods. This study is a non-randomized, open-label, controlled clinical trial. The study is registered on ClinicalTrials.gov. The inclusion criteria are listed on the site. All patients underwent CT and SPECT.Results. The study included 14 patients with MINOCA; the group comprised predominantly women (n=11, 78.6%); the average age was 61.1±14 years. The risk according to GRACE (Global Registry of Acute Coronary Events) risk score was moderate in 8 patients (57%) and high in 5 patients (35.7%). 85.7% of patients were admitted to hospital within the first six hours from onset of diseases. Three patients (21.4%) received thrombolytic therapy and it was effective in two of them (14%). Risk factors included hypertension (64.2%), dyslipidemia (50%), and burdened history (71.4). According to the results of invasive coronary angiography, intact coronary arteries were detected in 9 patients (64.3%); 5 patients (35.7%) had stenosis up to 50%. Coronary slow-flow phenomenon (TIMI 2) was detected in 11 patients (78.6%) including 8 patients (57.1%) who had coronary slow-flow phenomenon and intact coronary arteries. Severe coronary spasm was registered in 1 patient (7.1%) in the group with ST segment elevation acute coronary syndrome (STE ACS). According to MSCT data, the proportion of patients with intact coronary arteries decreased from 7 (50%) to 5 patients (35.7%) whereas the proportion of patients with nonstenosing atherosclerosis increased from 7 (50%) to 9 patients (64.3%). Twenty six atherosclerotic plaques were detected including eccentric (76%), circular (11.5%), and semi-circular plaques (11.5%). In regard to morphological structure, the atherosclerotic plaques were calcified (59.5%), mostly calcified (7.7%), and soft (29%). Normal myocardial perfusion (Summed Stress Score (SSS) and Summed Rest Score (SRS) <4) was detected in two patients (14.3%); 12 patients (85%) had transitory perfusion defects. The median score values were 7.5 (4; 13) for SSS, 4.7 (1.0; 9.0) for SRS, and 4.7 (3.0; 8.0) for SDS.Conclusion.The introduction of MCTA and SPECT into the algorithm of the examination of patients with acute myocardial infarction and non-obstructive atherosclerosis of the coronary arteries was safe when additionally used during index hospitalization. These approaches provided new information about the structure and function of the coronary arteries. These data provide rationale for further study using a larger group of patients to determine a prognostic significance of detecting the atherosclerotic plaques with the signs of instability in this patient category.
THE RESULTS OF STEP-BY-STEP MYOCARDIAL REVASCULARIZATION IN PATIENTS WITH ACUTE CORONARY SYNDROME AND MULTIVESSEL CORONARY ARTERY DISEASE: EARLY PERFORMING CORONARY ARTERY BYPASS SURGERY AFTER STENTING USING BARE-METAL STENTS
Authors: Bocharov A. V. , Popov L. V. 
Published: July 2019

Objective: To compare the long-term results of coronary artery bypass grafting performed in the early period after stenting for acute coronary syndrome by bare-metal stents with the results of coronary artery bypass grafting in patients with coronary heart disease.Material and Methods. The results of 24-month follow-up of step-by-step treatment of patients with acute coronary syndrome and multivessel lesion who received stenting of clinical-dependent artery with bare-metal stents as the first step and, then, underwent functional myocardial revascularization by aortocoronary bypass surgery within 90 days were analyzed. Results are presented as mean value and standard deviation (M±SD) in case of normal distribution and median with interquartile range in the form of 25 and 75 percentiles in case of non-normal distribution. The type of distribution of quantitative variables was assessed by the Lilliefors-corrected Kolmogorov–Smirnov test. Efficacy and safety assessments were carried out according to the criteria of non-inferiority in comparison with the literature data of myocardial revascularization by stenting. The differences were estimated using a two-way 95% confidence interval of the difference in adverse events based on the selected noninferiority design.Results. Surgical revascularization of the coronary bed in the early period after stenting of the clinically dependent artery using bare-metal stents in patients with acute coronary syndrome and multivessel lesion was equivalent to coronary artery bypass grafting, except for the rate of repeated revascularization.
DEVELOPMENT OF NONINVASIVE TOPICAL DIAGNOSTICS OF CARDIAC ARRHYTHMIAS
Authors: Khlynin M. S. , Batalov R. E. , Kiselev N. V. , Nam I. F. , Silivanov V. V. , Spisivtsev S. A. 
Published: July 2019

Heart arrhythmias may accompany virtually any cardiac disease. The problem of the preprocedure topical diagnostics of various arrhythmias remains fundamentally important and relevant, which is confirmed by numerous algorithms aimed at non-invasive detection of the arrhythmogenic focus location. Today, many different methods are available for non-invasive topical diagnostics of the arrhythmogenic foci in both ventricular and atrial arrhythmias. A non-invasive imaging of cardiac electrophysiology (NICE), based on the solution of the inverse problem of the electrocardiography, is the most advanced new technology. The accuracy of NICE reaches 90%, however, it is still inferior in its capabilities to the “reference” method of the invasive intracardiac electrophysiological examination. Currently, the market presents devices for both invasive mapping and NICE. However, in the context of surgery, an integrated system of non-invasive electrophysiological mapping with invasive three-dimensional electroanatomic mapping is of high demand. The creation of hybrid systems will allow to visualize electrophysiological processes in the epi- and endocardial surface in the real time with very high accuracy and to carry out the radiofrequency catheter ablation of arrhythmias with the simultaneous reduction of the radiation load on the patient and medical personnel.
PENGARUH KONSENTRASI BETASIKLODEKSTRIN TERHADAP KELARUTAN GLIMEPIRID
Authors: Darusman Fitrianti , Siti M Ulfa 
Published: July 2019

Glimepirid (GMP) merupakan obat antidiabetika oral golongan sulfonilurea generasi ketiga yang mampu menurunkan kadar glukosa darah dengan efek samping hipoglikemia yang kecil. Namun GMP termasuk ke dalam Biopharmaceutical Classification System (BCS) kelas II yang memiliki kelarutan praktis tidak larut dalam air sehingga berpengaruh pada laju disolusi dan bioavailabilitasnya. Salah satu upaya untuk meningkatkan kelarutan GMP yaitu dengan pembentukan kompleks inklusi menggunakan betasiklodekstrin (BCD). Penentuan terbentuknya kompleks inklusi GMP-BCD menggunakan beberapa konsentrasi larutan BCD yang semakin meningkat dalam dapar asetat 0,01 M pH 6,2 dan dapar fosfat 0,01 M pH 7,4 yang diteliti dengan metode kelarutan dan ditentukan secara spektrofotometri ultraviolet pada panjang gelombang serapan maksimum 228 nm. Hasil penelitian menunjukkan bahwa kelarutan GMP meningkat dengan semakin meningkatnya konsentrasi BCD dengan harga tetapan stabilitas kompleks pada pH 7,4 lebih sebesar 0,650 lebih besar dari pada pH 6,2 yaitu sebesar 0,237 .
Intestinal parasitic infection in wild animals of a zoological garden in Alborz, Iran
Authors: NASİRİ Vahid , JAMEİE Farnoosh 
Published: July 2019

Here we studied the intestinal parasites in animals at a zoological garden in Alborz, Iran. A total of 83 fecal samples from various captive wild animals, consisting of 21 different species were collected randomly and analyzed for the presence of the different stages of parasites by direct smear preparation and zinc sulfate flotation followed by Ziel-Neelsen staining method. The examined animals in this study consist of 7 species of carnivores (26 samples), 10 species of herbivores (46 samples), and 4 species of different groups of birds (11 samples). Examination of fecal samples revealed that 22 (26.50%) of animals, that belonging to 7 animal species, were infected with different intestinal parasites. Among gastrointestinal parasites positive captive wild animals 18 samples (21.68 %) belong to herbivores and 4 samples (4.81 %) to Aves. Among captive wild animals the prevalence of parasites was higher in herbivores (21.68%) followed by Aves (4.81). Results indicated that out of 22 animal samples that parasites were encountered, 14 (16.86%) were infected with helminths (Trichuris spp., Nematodirus spp., Ascaridia galli and some unknown Nematodes eggs) and 8 (9.63%) were infected with protozoa (Oocysts of Eimeria sp.). In the conclusion, it could be resulted that there is a need of control measures against the spread of infectious parasitic diseases among animals within the zoo.
Strategy optimization in the acute pancreatitis treatment
Authors: V. I. Robak  , D. V. Ievtushenko  , O. G. Petiunin  , L. O. Drana  
Published: July 2019

The aim — to analyze the efficacy of ethyl methylhydroxypyridine succinate (Lodixem) and the combination of ethylmethylhydroxypyridine succinate and pentoxifylline in a Ringer Lactate solution (Lodixem + Latren) in the treatment of patients with acute pancreatitis.Materials and methods. The treatment results analysis in 120 patients with acute pancreatitis was performed. Men were 67 (55.8 %), women — 53 (44.2 %). The patients’ age was from 19 to 82 years (average age — 44.23 ± 2.51 years). Patients receiving standard therapy were divided into two groups: group 1A — 30 patients who received ethylmethylhydroxypyridine succinate in addition to standard therapy, group 1B — 30 patients who received ethylmethylhydroxypyridine succinate and pentoxyphylline in Ringer’s lactate solution in addition to standard therapy. The treatment results of 60 patients with acute pancreatitis treated in the surgical department in the period from 2016 to 2018 (the control group) were retrospectively analyzed. The criterion for inclusion in the study was the presence of acute pancreatitis (Atlanta, 2013), the early stage of the disease, the exclusion criteria — severe acute hepatic or renal failure, hypersensitivity to Latren or Lodiksem in anamnesis, childhood, pregnancy, breastfeeding period. The following clinical and laboratory indicators were evaluated: peripheral blood reaction, basic biochemical parameters, electrolytes in the blood, general state on integral scales to determine the diagnostic criteria for the course of acute pancreatitis on admission to hospital (day 0) and on the 1st, 3rd and 5th day of treatment,.Results and discussion. A statistically significant decrease in leukocyte levels, leukocyte intoxication index, intoxication index and C‑reactive protein content was noted in all groups, however, the rate of decline was more pronounced in groups 1A and 1B. Ranson, Simplified Acute Physiology Score II, Acute Sepsis Severity Evaluation Scale score of patients was assessed by a statistically significant reduction in patient groups treated with ethylmethylhydroxypyridine succinate and a combination of the latter with pentoxyphylline in Ringer’s lactate solution.Conclusions. The ethyl methylhydroxypyridine succinate in combination with pentoxifylline in a Ringer’s solution of lactate reduces the appearance of intoxication and stimulates reparative processes in the acute pancreatitis treatment. At the 5th day there was a significant decrease in the ASSES scale marks (up to 6.11 ± 0.37) and on the Ranson scale ones (up to 1.8 ± 0.9 points) in patients with the proposed treatment regimen. This treatment scheme can be recommended for inclusion into the treatment protocols for patients with pancreatic inflammation.