bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occlusal trauma and excessive occlusal forces: Narrative review, case definitions, and diagnostic considerations
Authors: Fan Jingyuan , Caton Jack G. 
Published: June 2018

AbstractObjectivesThis narrative review determines the effects of occlusal trauma and excessive occlusal forces on the periodontium, including the initiation and progression of periodontitis, abfraction, and gingival recession. Case definitions, diagnostic considerations, and the effects of occlusal therapy are also reviewed and discussed.ImportanceThe role of occlusal trauma in the initiation and progression of periodontitis remains a controversial subject in periodontology. Because occlusal trauma can only be confirmed histologically, its clinical diagnosis depends on clinical and radiographic surrogate indicators which make clinical trials difficult.FindingsInvestigations have generally agreed that occlusal trauma and excessive occlusal forces do not initiate periodontitis or loss of connective tissue attachment. When plaque‐induced periodontitis and occlusal trauma are present at the same time, there is weak evidence that the occlusal trauma may increase the rate of connective tissue loss. Occlusal therapy is indicated as part of periodontal therapy to reduce mobility and increase patient comfort and masticatory function. Existing data do not support the existence of abfraction as a cause for gingival recession.ConclusionsOcclusal trauma does not initiate periodontitis, and there is weak evidence that it alters the progression of the disease. There is no credible evidence to support the existence of abfraction or implicate it as a cause of gingival recession. Reduction of tooth mobility may enhance the effect of periodontal therapy.
Lactobacillus acidophilus suppresses intestinal inflammation by inhibiting endoplasmic reticulum stress
Authors: Kim Da Hye , Kim Soochan , Lee Jin Ha , Kim Jae Hyeon , Che Xiumei , Ma Hyun Woo , Seo Dong Hyuk , Kim Tae II , Kim Won Ho , Kim Seung Won , Cheon Jae Hee 
Published: June 2018

AbstractBackground and AimNuclear factor kappa B (NF‐κB) activation and endoplasmic reticulum (ER) stress signaling play significant roles in the pathogenesis of inflammatory bowel disease (IBD). Thus, we evaluated whether new therapeutic probiotics have anti‐colitic effects, and we investigated their mechanisms related to NF‐κB and ER‐stress pathways.MethodsLuciferase, nitric oxide, and cytokine assays using HT‐29 or RAW264.7 cells were conducted. Mouse colitis was induced using dextran sulfate sodium and confirmed by disease activity index and histology. Macrophages and T‐cell subsets in isolated peritoneal cavity cells and splenocytes were analyzed by flow cytometry. Gene and cytokine expression profiles were determined using reverse‐transcription polymerase chain reaction.ResultsLactobacillus acidophilus (LA1) and Pediococcus pentosaceus inhibited nitric oxide production in RAW264.7 cells, but only LA1 inhibited Tnfa and induced Il10 expression. LA1 increased the lifespan of dextran sulfate sodium‐treated mice and attenuated the severity of colitis by inducing M2 macrophages in peritoneal cavity cells and Th2 and Treg cells in splenocytes. The restoration of goblet cells in the colon was accompanied by the induction of Il10 expression and the suppression of pro‐inflammatory cytokines. Additionally, we found that LA1 exerts an anti‐colitic effect by improving ER stress in HT‐29 cells as well as in vivo.ConclusionsWe showed that LA1 significantly interferes with ER stress and suppresses NF‐κB activation. Our findings suggest that LA1 can be used as a potent immunomodulator in IBD treatment, and the regulation of ER stress may have significant implications in treating IBD.
Eye movement desensitization and reprocessing as a treatment for PTSD: current neurobiological theories and a new hypothesis
Authors: Calancie Olivia G. , Khalid‐Khan Sarosh , Booij Linda , Munoz Douglas P. 
Published: June 2018

AbstractEye movement desensitization and reprocessing (EMDR), a form of psychotherapy for individuals with post‐traumatic stress disorder (PTSD), has long been a controversial topic, hampered in part by a lack of understanding of the neural mechanisms that contribute to its remedial effect. Here, we review current theories describing EMDR's potential neurobiological mechanisms of action involving working memory, interhemispheric communication, de‐arousal, and memory reconsolidation. We then discuss recent studies describing the temporal and spatial aspects of smooth pursuit and predictive saccades, which resemble those made during EMDR, and their neural correlates within the default mode network (DMN) and cerebellum. We hypothesize that if the production of bilateral predictive eye movements is supportive of DMN and cerebellum activation, then therapies that shift the brain towards this state correspondingly would benefit the processes regulated by these structures (i.e., memory retrieval, relaxation, and associative learning), all of which are essential components for PTSD recovery. We propose that the timing of sensory stimulation may be relevant to treatment effect and could be adapted across different patients depending on their baseline saccade metrics. Empirical data in support of this model are reviewed and experimental predictions are discussed.
Left ventricular sphericity index analysis for the prediction of appropriate implantable cardioverter‐defibrillator therapy
Authors: Anvari Shideh , Akbarzadeh Mohammad Ali , Bayat Fariba , Namazi Mohammad Hasan , Safi Morteza 
Published: June 2018

AbstractBackgroundImplantable cardioverter‐defibrillator (ICD) is the most effective therapy currently available to prevent sudden cardiac death (SCD) in patients with left ventricular (LV) dysfunction. Although LV ejection fraction (LVEF) is an excellent marker of SCD in these patients, determining other predictors might help to identify patients who will be benefit more from device implantation. The purpose of this study was to determine whether abnormal LV sphericity index (SI) in transthoracic echocardiography is associated with appropriate ICD therapy in these patients.MethodsA total of 140 patients with primary ICD implantation (mean age 62.59 ± 11.36 years; 98 [70%] male) were included. The patients were classified into “no ICD therapy” or “ICD therapy” group according to the information of their devices for a maximum of 2 previous years. In four‐chamber view image of transthoracic echocardiography, SI was calculated by dividing the major‐axis dimension to minor‐axis dimension of LV in both groups.ResultsCompared with patients with no ICD therapy, patients in ICD therapy group had lower LVEF (31.36 ± 9.58 vs 23.24 ± 6.03, P = 0.0001) and lower SI (1.79 ± 0.29 vs 1.57 ± 0.32, P = 0.0001). In multivariant logistic regression analysis, the SI of ≤1.58 was associated with fourfold increase of appropriate ICD therapy, even after adjusting for LVEF (odds ratio, 4.08; 95% confidence interval, 1.71–9.75; P = 0.02).ConclusionSimple echocardiographic sphericity dimension index as a marker of cardiac remodeling may be an important predictor of appropriate ICD therapy in patients with primary prevention ICDs and may provide additive risk stratification in patients with LV systolic dysfunction.
Multifunctionality of pond fish farms in the opinion of the farm managers: the case of Hungary
Authors: Popp József , Békefi Emese , Duleba Szabolcs , Oláh Judit 
Published: June 2018

AbstractFreshwater fish ponds, besides producing fish, function as valuable aquatic habitats, contribute to the maintenance and enrichment of the quality of the ecosystem, play an important role in water and landscape management, provide services for various recreational activities and contribute to the preservation of the cultural heritage. The multifunctional character of pond fish farming has been recognized for long time; however, recently it has also been realized that the deliberate multidirectional use of fish ponds (production, angling, recreation, education, etc.) offers additional economic benefits. Experience with the operation of multifunctional fish farms in Hungary has clearly shown that the diversification of activities is a promising alternative during the development of sustainable pond fish farming. However, further efforts are required to investigate the specificities and applicability of the various factors and also the optimal ratio between them to utilize the opportunities offered by multifunctional use of freshwater fish ponds. Research on multifunctional pond fish farming has mainly been limited to descriptions of the various functions of fish ponds, for example environmental services. However, the attitude of farm managers towards the possible multifunctional use of their farming system has never been investigated. In this study, the importance of the various existing or potential functions of a pond fish farm and their role in the future development of multifunctional pond fish farms have been investigated through the analysis of the appraisal of experienced farm managers by analytic hierarchy process. The results of the research provide empirical evidence that can be used for the elaboration of policies, development strategies, R&D and the legal frameworks needed for the sustainable development of multifunctional pond fish farming.
Relations Between Language and Cognition: Evidentiality and Sources of Knowledge
Authors: Ünal Ercenur , Papafragou Anna 
Published: June 2018

AbstractUnderstanding and acquiring language involve mapping language onto conceptual representations. Nevertheless, several issues remain unresolved with respect to (a) how such mappings are performed, and (b) whether conceptual representations are susceptible to cross‐linguistic influences. In this article, we discuss these issues focusing on the domain of evidentiality and sources of knowledge. Empirical evidence in this domain yields growing support for the proposal that linguistic categories of evidentiality are tightly linked to, build on, and reflect conceptual representations of sources of knowledge that are shared across speakers of different languages.
Rock-based 3-D reservoir characterization of a Silurian (Niagaran) reef—Ray gas storage field, Macomb County, Michigan
Authors: Wold Jessica L. , Grammer G. Michael 
Published: June 2018

ABSTRACT
Silurian-age (Niagaran) reefs in the Michigan Basin have long been interpreted as relatively homogeneous units, despite production histories that strongly suggest the reefs are heterogeneous in both lateral and vertical dimensions. In an attempt to better illustrate reservoir heterogeneity in these reefs, a three-dimensional (3-D) sequence stratigraphic model was produced for the Ray Reef field. The resulting 3-D Petrel model incorporates 28 wells in the field using a combination of gamma-ray and neutron logs, porosity and permeability data from whole-core analysis, and facies descriptions from eight cores evenly distributed within the reef complex. Comparison of porosity and permeability values within the diverse depositional facies clearly shows trends related to the individual facies and positioning within the sequence hierarchy. Incorporation of the sequence stratigraphic framework into the 3-D model illustrates the episodic nature of reef growth as exhibited by the stacked nature of reef and capping grainstones, often separated by well-developed exposure horizons. The model also suggests a distinct difference between windward and leeward margins in both the geometry of the reef complex and the distribution of reservoir-prone facies. Windward margins are steeper due to higher rates of aggradational growth, and they typically contain higher percentages of reservoir-quality rock in both the reef core and forereef facies. Utilization of the sequence stratigraphic approach illustrates that the vertical reservoir heterogeneity often predicted from production in these reefs may be controlled in large part by the combination of vertical stacking patterns of facies within third- and fourth-order sequences.
Cost-effective analysis of teaching pelvic examination skills using Gynaecology Teaching Associates (GTAs) compared with manikin models (The CEAT Study)
Authors: Janjua Aisha , Roberts Tracy , Okeahialam Nicola , Clark T Justin 
Published: June 2018

ObjectiveTo determine the cost-effectiveness of Gynaecology Teaching Associate (GTA) teaching versus conventional pelvic model (manikin) teaching of pelvic examination skills for final year medical students within a UK undergraduate obstetrics and gynaecology (O&G) curriculum.MethodsAn economic evaluation was carried out alongside a randomised controlled trial involving 492 final year medical students. 240 students received manikin teaching, and 241 GTA-led teaching. 418 (85%) students completed their assessment. Proficiency in gynaecological pelvic examination on GTAs was estimated by a senior clinical examiner, blinded to the method of teaching, using a standardised assessment tool. University of Birmingham Medical School thresholds were applied to determine proficiency levels; competence (pass) 50%, merit 60% and distinction 70%. Costs incurred in the delivery of both the educational pathways (control and intervention) were combined. All costs are reported in 2013–2014 prices and earlier costs adjusted using inflation indices.Outcome measuresCost per student competent in pelvic examination at completion of a 5-week clinical O&G placement.ResultsGTA teaching was more effective compared with conventional teaching with 12 more students considered competent at pass level and 28 more students competent at merit and distinction levels, respectively. However, the average cost of GTA teaching was £45.06 per student compared with £7.40 per student for conventional teaching, with an increased cost of £37.66 per student. The incremental cost-effectiveness ratio demonstrated that it cost an additional £640.20 per competent student and £274.37 per student competent at merit level and £274.37 at distinction level compared with conventional manikin-based teaching.ConclusionsGTA teaching of female pelvic examination at the start of undergraduate medical student O&G clinical placements is shown to cost more and be more effective. GTA teaching is likely to be considered cost-effective in the context of other tests, and over the lifespan of a competent doctor’s career.Trial registration numberNCT01944592.
Association between acculturation and body weight status among migrant children in Guangzhou, China: a cross-sectional study
Authors: Huang Xiaoling , Chen Wen , Lin Yanwei , Zhang Qi , Ling Li 
Published: June 2018

ObjectiveTo assess the association between acculturation and body weight status among internal migrant children in China.Design, setting and participantsA cross-sectional study was conducted among 1154 pairs of migrant children aged 11–17 years and their primary caregivers in Guangzhou, China, from April to May 2016.MeasuresMigrant children’s body weight status was measured by body mass index. Acculturation was measured by a questionnaire, developed and validated by the research team. The questionnaire had three dimensions with five factors, namely language, social interaction, custom, dressing and diet. Social anxiety was measured by Social Anxiety Scale for Children. Food intake was measured by the food frequency table that was developed from a previous study. Logistic regression was performed to examine the association between acculturation and overweight/obesity while controlling for migrant children’s and their caregivers’ demographic characteristics, children’s social anxiety and food intake.ResultsSeventy-six out of 1154 (6.6%) migrant children were overweight, and 36 (3.1%) were obese. The overall prevalence of overweight/obesity was 12.5% in boys, and 6.1% in girls (p<0.001), respectively. The mean scores of acculturation were 41.8 (SD=14.6). Migrant children had the highest level of acculturation in the aspect of dressing (mean=61.7, SD=16.6), followed by language (mean=47.9, SD=22.3), diet (mean=45.0, SD=18.5), social interaction (mean=42.4, SD=21.3) and custom (mean=27.6, SD=19.2). After controlling for confounding factors, the levels of acculturation was negatively associated with overweight/obesity (adjusted OR (aOR)=0.98, 95% CI 0.97 to 1.00, p=0.030). Furthermore, migrant children who had urban-to-urban migrant caregivers were more likely to be overweight/obese (aOR=2.07, 95% CI 1.16 to 3.69, p=0.014) than their counterparts living with rural-to-urban migrant caregivers.ConclusionsThe low levels of acculturation was associated with overweight/obesity among migrant children in Guangzhou, China. Promoting healthy acculturation and social campaign on healthy body weight may help prevent childhood overweight/obesity. Young migrant children, boys and children living with urban-to-urban migrant caregivers should be the target subgroups.
Risk of postneonatal mortality, hospitalisation and suboptimal breast feeding practices in low birthweight infants from rural Haryana, India: findings from a secondary data analysis
Authors: Upadhyay Ravi Prakash , Martines Jose Carlos , Taneja Sunita , Mazumder Sarmila , Bahl Rajiv , Bhandari Nita , Dalpath Suresh , Bhan Maharaj Kishan 
Published: June 2018

ObjectivesLow birth weight (LBW) is a risk factor for neonatal mortality and morbidity. It is important to examine whether this risk persists beyond neonatal period. The current secondary data analysis aimed to examine association of birth weight with mortality, hospitalisation and breast feeding practices during infancy.DesignData from a large randomised controlled trial of neonatal vitamin A supplementation (Neovita) trial were used. Log binomial model was applied to assess association between birth weight and mortality, hospitalisation and breast feeding practices.SettingRural Haryana, North India.ParticipantsNewborns recruited in the primary intervention trial that aimed to evaluate the effect of single-dose oral vitamin A supplementation on mortality in the first 6 months of life.ResultsWe recruited a total of 44 984 infants, of which 10 658 (23.7%) were born LBW, that is, birth weight less than 2500 g. In the neonatal period, LBW babies had four times higher risk of mortality (relative risk (RR) 3.92; 95% CI 3.33 to 4.66) compared with normal birthweight babies. In the postneonatal period, the risk was two times higher (RR 1.92; 95% CI 1.71 to 2.15); even higher in those with birth weight <2000 g (RR 3.38; 95% CI 2.71 to 4.12). The risk of hospitalisation in the neonatal period and postneonatal period was (RR 1.86; 95% CI 1.64 to 2.11) and (RR 1.13; 95% CI 1.05 to 1.21), respectively. LBWs were at increased risk of breast feeding initiation 24 hours after birth (RR 1.64; 95% CI 1.45 to 1.81), no breast feeding at 6 months (RR 1.34; 95% CI 1.23 to 1.46) and at 12 months of age (RR 1.24; 95% CI 1.18 to 1.30).ConclusionsLBW babies, especially those with birth weight of <2000 g, were at increased risk of mortality, hospitalisation and suboptimal breast feeding practices during entire infancy and therefore require additional care beyond the first 28 days of life.Trial registration numberNCT01138449.
A Remark on Rainbow 6-Cycles in Hypercubes
Authors: Hao Chen , Yang Weihua 
Published: June 2018

We call an edge-coloring of a graph [Formula: see text] a rainbow coloring if the edges of [Formula: see text] are colored with distinct colors. For every even positive integer [Formula: see text], let [Formula: see text] denote the minimum number of colors required to color the edges of the [Formula: see text]-dimensional cube [Formula: see text], so that every copy of [Formula: see text] is rainbow. Faudree et al. [6] proved that [Formula: see text] for [Formula: see text] or [Formula: see text]. Mubayi et al. [8] showed that [Formula: see text]. In this note, we show that [Formula: see text]. Moreover, we obtain the number of 6-cycles of [Formula: see text].
Accuracy of a Novel Handheld Wireless Platform for Detection of Cardiac Dysfunction in Anthracycline-Exposed Survivors of Childhood Cancer
Authors: Armenian Saro H. , Rinderknecht Derek , Au Kaylene , Lindenfeld Lanie , Mills George , Siyahian Aida , Herrera Claudia , Wilson Karla , Venkataraman Kalyanasundaram , Mascarenhas Kristen , Tavallali Peyman , Razavi Marianne , Pahlevan Niema , Detterich Jon , Bhatia Smita , Gharib Morteza 
Published: June 2018

Abstract
Purpose: Childhood cancer survivors are at risk for anthracycline-related cardiac dysfunction, often developing at a time when they are least engaged in long-term survivorship care. New paradigms in survivorship care and chronic disease screening are needed in this population. We compared the accuracy of a novel handheld mHealth platform (Vivio) as well as echocardiography for assessment of cardiac function [left ventricular ejection fraction (EF)] in childhood cancer survivors with cardiac magnetic resonance (CMR) imaging (reference).
Experimental Design: Cross-sectional study design was used. Concurrent evaluation of EF was performed using Vivio, two-dimensional (2D) echocardiography, and CMR. Differences in mean EF (2D echocardiography vs. CMR; Vivio vs. CMR) were compared using Bland–Altman plots. Linear regression was used to evaluate proportional bias.
Results: A total of 191 consecutive survivors participated [50.7% female; median time from diagnosis: 15.8 years (2–44); median anthracycline dose: 225 mg/m2 (25–642)]. Echocardiography overestimated mean EF by 4.9% (P &lt; 0.001); linear regression analysis confirmed a proportional bias, when compared with CMR (t = 3.1, P &lt; 0.001). There was no difference between mean EF derived from Vivio and from CMR (–0.2%, P = 0.68). The detection of cardiac dysfunction via echocardiography was poor when compared with CMR [Echo EF &lt; 45% (sensitivity 14.3%), Echo EF &lt; 50% (sensitivity 28.6%)]. Sensitivity was substantially better for Vivio-based measurements [EF &lt; 45% or EF &lt; 50% (sensitivity 85.7%)].
Conclusions: This accessible technology has the potential to change the day-to-day practice of clinicians caring for the large number of patients diagnosed with cardiac dysfunction and heart failure each year, allowing real-time monitoring and management of their disease without the lag-time between imaging and interpretation of results. Clin Cancer Res; 24(13); 3119–25. ©2018 AACR.