bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heavy Rainfall Duration Bias in Dynamical Downscaling and Its Related Synoptic Patterns in Summertime Asian Monsoon
Authors: Tamaki Yuta , Inatsu Masaru , Nguyen-Le Dzung , Yamada Tomohito J. 
Published: May 2018

AbstractDynamical downscaling (DDS) was conducted over Japan by using a regional atmospheric model with reanalysis data to investigate the rainfall duration bias over Kyushu, Japan, in July and August from 2006 to 2015. The model results showed that DDS had a positive rainfall duration bias over Kyushu and a dry bias over almost all of Kyushu, which were emphasized for extreme rainfall events. Investigated was the rainfall duration bias for heavy rainfall days, accompanied by synoptic-scale forcing, in which daily precipitation exceeded 30 mm day−1 and covered over 20% of the Kyushu area. Heavy rainfall days were sampled from observed rainfall data that were based on rain gauge and radar observations. A set of daily climatic variables of horizontal wind and equivalent potential temperature at 850 hPa and sea level pressure, around southwestern Japan, corresponding to the sampled dates, was selected to conduct a self-organizing map (SOM) and K-means method. The SOM and K-means method objectively classified three synoptic patterns related to heavy rainfall over Kyushu: strong monsoon, weak monsoon, and typhoon patterns. Rainfall duration had a positive bias in western Kyushu for the strong monsoon pattern and a positive bias in southern and east-coast Kyushu for the typhoon pattern, whereas there was little rainfall duration bias in the weak monsoon pattern. The bias for the typhoon pattern was related to rainfall events with a strong rainfall peak. The results suggest that bias correction for rainfall duration would be required for accurately estimating direct runoff in a catchment area in addition to the precipitation amount.
Improving Particle Filter Performance by Smoothing Observations
Authors: Robinson Gregor , Grooms Ian , Kleiber William 
Published: May 2018

AbstractThis article shows that increasing the observation variance at small scales can reduce the ensemble size required to avoid collapse in particle filtering of spatially extended dynamics and improve the resulting uncertainty quantification at large scales. Particle filter weights depend on how well ensemble members agree with observations, and collapse occurs when a few ensemble members receive most of the weight. Collapse causes catastrophic variance underestimation. Increasing small-scale variance in the observation error model reduces the incidence of collapse by de-emphasizing small-scale differences between the ensemble members and the observations. Doing so smooths the posterior mean, though it does not smooth the individual ensemble members. Two options for implementing the proposed observation error model are described. Taking a discretized elliptic differential operator as an observation error covariance matrix provides the desired property of a spectrum that grows in the approach to small scales. This choice also introduces structure exploitable by scalable computation techniques, including multigrid solvers and multiresolution approximations to the corresponding integral operator. Alternatively the observations can be smoothed and then assimilated under the assumption of independent errors, which is equivalent to assuming large errors at small scales. The method is demonstrated on a linear stochastic partial differential equation, where it significantly reduces the occurrence of particle filter collapse while maintaining accuracy. It also improves continuous ranked probability scores by as much as 25%, indicating that the weighted ensemble more accurately represents the true distribution. The method is compatible with other techniques for improving the performance of particle filters.
Life Cycle Effects on the Vertical Structure of Precipitation in East China Measured by Himawari-8 and GPM DPR
Authors: Zhang Aoqi , Fu Yunfei 
Published: May 2018

AbstractWe identified precipitating systems from May to August 2016 using data from the Global Precipitation Measurement mission Dual-frequency Precipitation Radar instrument. Then, using this set of cases, Himawari-8 10.4-μm brightness temperature data from before and after each precipitation event were used to identify three life stages of clouds: a developing stage, a mature stage, and a dissipating stage. Using statistical analysis and two case studies, we show that the precipitating systems at different life stages of the clouds have different systematic properties, including the area of precipitation, the convective ratio, the rain-top height, and the brightness temperature. The developing systems had the largest convective ratio, whereas the dissipating systems had the largest area of precipitation. The life stage of the cloud also influenced the vertical structure of the precipitation. The microphysical processes within each stage were unique, leading to various properties of the droplets in precipitation. The developing systems had large, but sparse, droplets; the mature systems had large and dense droplets; and the dissipating systems had small and sparse droplets. Our results suggest that the different properties of precipitating systems in each life cycle stage of clouds are linked to the cloud water content and the upward motion of air.
The calibration of force offset for rocket engine based on deep belief network
Authors: Zhang Jun , Tian Yu , Ren Zongjin , Chang Qingbing , Jia Zhenyuan 
Published: May 2018

Background Force offset is an important movement and control parameter in rocket motor development process, and its accurate measurement is a vital guarantee of rocket motor reliable operation, so there is an essential significance to achieve accurate force offset calibration. Methods A novel force offset nonlinear calibration method is proposed based on deep belief network. Experimental platform is established and force offset calibration test is completed. Because the Levenberg -Marquardt process has the advantage of both Newton method and gradient descent method, test data are trained with Levenberg -Marquardt, decreasing nonlinear mapping convergence errors and realizing nonlinear calibration of force offset. Results and Conclusions Training results show that the mean deviation rate of force offset after nonlinear calibration is less than 2.7%, better than the back-propagation neural network and least squares method, verifying the reasonableness and practicality of nonlinear compensation calibration method and effectively improving force offset calibration accuracy.
Veno-arterio-venous ECMO for septic cardiomyopathy: a single-centre experience
Authors: Vogel Dominik J. , Murray Josie , Czapran Adam Z. , Camporota Luigi , Ioannou Nicholas , Meadows Chris I. S. , Sherren Peter B. , Daly Kathleen , Gooby Nigel , Barrett Nicholas 
Published: May 2018

Introduction: The role of extracorporeal support for patients with septic shock remains unclear. Methods: We conducted a retrospective analysis of our single-centre experience with veno-arterio-venous extracorporeal membrane oxygenation (VAV ECMO) in adult patients with severe respiratory failure and septic cardiomyopathy. Clinical data was extracted from electronic medical records including a dedicated ECMO referral and follow-up database. Results: Twelve patients were commenced on VAV ECMO for septic cardiomyopathy for a median of four days (IQR 3.0 to 5.3) between 01/2014 and 12/2017. Five patients (41.7%) had a cardiac arrest prior to initiation of ECMO support. At baseline, median left ventricular ejection fraction was 16.25% (IQR 13.13 to 17.5) and median PaO2/FiO2 ratio was 9 kPa (IQR 6.5 to 12.0) [67.50 mmHg (IQR 48.75 to 90.00)]. The survival rate to hospital discharge for VAV ECMO was 75% in this cohort. None of the surviving patients died within the follow-up period (median six month). Conclusion: VAV ECMO is a feasible rescue strategy for a small proportion of patients with combined respiratory and cardiac failure secondary to septic shock with septic cardiomyopathy. We provide a detailed report of our experience with this technique. Further research is required comparing the different extracorporeal strategies directly to conventional resuscitation and against each other.
Acute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers
Authors: Valentine Gerald W , DeVito Elise E , Jatlow Peter I , Gueorguieva Ralitza , Sofuoglu Mehmet 
Published: May 2018

Objective: This double-blind, placebo controlled study examined whether menthol inhaled from an electronic cigarette (e-cigarette) would change subjective and withdrawal alleviating effects of intravenous nicotine in young adult smokers. Methods: A total of 32 menthol-preferring smokers and 25 non-menthol-preferring smokers participated in the study that consisted of a random sequence of three different inhaled menthol conditions (0.0%, 0.5%, and 3.2%) across three test sessions (a single menthol condition per session). In each test session (performed at least 24 hours apart), a random order of saline, and two different nicotine infusions of 0.25 mg and 0.5 mg/70 kg of bodyweight were administered, one hour apart, concurrent with menthol inhalation. Results: While menthol did not alter the positive subjective effects of nicotine, menthol significantly enhanced aversive effects of nicotine in non-menthol-preferring smokers and reduced smoking urges in menthol-preferring smokers. In addition, menthol-preferring smokers reported blunted positive subjective responses to nicotine and less severe nicotine withdrawal after overnight nicotine deprivation. Finally, compared to non-menthol-preferring smokers, menthol-preferring smokers had a significantly lower baseline nicotine metabolite ratio indicating slower nicotine metabolism within our sample of menthol-preferring smokers. Conclusions: Our findings did not support an enhancement of nicotine’s positive subjective effects from inhaled menthol. However, as compared to non-menthol-preferring smokers, menthol-preferring smokers had blunted positive subjective responses to nicotine and reduced overnight withdrawal severity that may be partly due to inhibition of nicotine metabolism from chronic exposure to inhaled menthol. Collectively, these results reveal a more complex and nuanced role of inhaled menthol in smokers than previously recognized.
Radiographic analysis of the correlation between ossification of the nuchal ligament and sagittal alignment and segmental stability of the cervical spine in patients with cervical spondylotic myelopathy
Authors: Ying Jinwei , Teng Honglin , Qian Yunfan , Hu Yingying , Wen Tianyong , Ruan Dike , Zhu Minyu 
Published: May 2018

Background Ossification of the nuchal ligament (ONL) caused by chronic injury to the nuchal ligament (NL) is very common in instability-related cervical disorders. Purpose To determine possible correlations between ONL, sagittal alignment, and segmental stability of the cervical spine. Material and Methods Seventy-three patients with cervical spondylotic myelopathy (CSM) and ONL (ONL group) and 118 patients with CSM only (control group) were recruited. Radiographic data included the characteristics of ONL, sagittal alignment and segmental stability, and ossification of the posterior longitudinal ligament (OPLL). We performed comparisons in terms of radiographic parameters between the ONL and control groups. The correlations between ONL size, cervical sagittal alignment, and segmental stability were analyzed. Multivariate logistic regression was used to identify the independent risk factors of the development of ONL. Results C2–C7 sagittal vertical axis (SVA), T1 slope (T1S), T1S minus cervical lordosis (T1S-CL) on the lateral plain, angular displacement (AD), and horizontal displacement (HD) on the dynamic radiograph increased significantly in the ONL group compared with the control group. The size of ONL significantly correlated with C2–C7 SVA, T1S, AD, and HD. The incidence of ONL was higher in patients with OPLL and segmental instability. Cervical instability, sagittal malalignment, and OPLL were independent predictors of the development of ONL through multivariate analysis. Conclusion Patients with ONL are more likely to have abnormal sagittal alignment and instability of the cervical spine. Thus, increased awareness and appreciation of this often-overlooked radiographic finding is warranted during diagnosis and treatment of instability-related cervical pathologies and injuries.
Owner-reported flea treatment measures and skin disease in cats
Authors: Tyler Sophie , Roberts Claire , Foster Aiden , Barnard Natalie , Murray Jane K 
Published: May 2018

Objectives The aim of this study was to obtain information regarding the use of flea treatments and owner-reported flea infestation and skin disease. Methods Owners of 1150 cats were recruited into a long-term longitudinal study (‘Bristol Cats’ study) and asked to complete questionnaires at set time points. Questionnaires 1 and 5 were used and included data collection for kittens aged 2–4 months (T1) and at 2.5 years of age (T2). Owners were asked which brand of flea treatment, if any, was used at each time point. At T2 owners were asked if they had noted signs of skin disease or fleas on their cat within the previous 12 months and if they had sought veterinary attention for the skin disease or fleas. IBM SPSS version 23 was used for statistical analyses. Results Skin disease at T2 was reported by owners of 55/1150 (4.8%; 95% confidence interval [CI] 3.7–6.2) cats. Many owners who reported skin disease (25/55 [45.5%]; 95% CI 32.3–58.7) had not sought veterinary attention. There were 81/1150 (7.0%; 95% CI 5.6–8.5) cats with reported head shaking and/or ear scratching within the past 12 months at T2. The majority of cats (204/286; 71.3%) received prescription flea treatments at both points. Use of non-prescription flea treatment at T2 was more likely to be associated with owner-reported skin disease/flea infestation than those who used prescription flea treatment ( P <0.001). There was a significant association between the reported presence of fleas and reported presence of skin disease at T2 ( P = 0.03). Conclusions and relevance Despite the potential for reverse causality, the association between owner-reported skin disease and/or flea infestation in their cats and the use of non-prescription flea treatment was as expected. Use of flea treatments and, in particular, the type of ectoparasite control used (prescription or non-prescription) should be carefully assessed when managing cats with skin disease.
Feline injection site sarcoma: immunohistochemical characteristics
Authors: Carneiro Carolina S , de Queiroz Genilson F , Pinto Ana CBCF , Dagli Maria LZ , Matera Julia M 
Published: May 2018

Objectives Feline injection site sarcoma (FISS) is a rapid growing locally aggressive tumor with a low metastatic rate. Its histologic features are clearly defined, but there are few studies regarding its immunohistochemical characteristics. The present study investigated the immunohistochemical characteristics of 21 cases of FISS. Methods FISSs from 12 male and nine female cats, 20 mixed-breed and one Siamese, were included in the study. After histopathological diagnosis, additional histologic sections were immunostained for vimentin, cytokeratin, desmin, S100 protein, viral feline leukemia virus (FeLV) particles, cyclooxygenase 2 (COX-2) and c-KIT. Positive and negative controls were adopted accordingly. Immunostainings were classified as positive or negative according to the number of positive cells from a total of 1000 cells per tumor section. Results Histopathologic diagnosis of the tumors revealed 18 (85.7%) fibrosarcomas and three (14.3%) other sarcomas; four fibrosarcomas (22.2%) were grade III, five (27.8%) were grade II and nine (50.0%) were grade I. Two sarcomas were grade III and one was grade II. Seventeen (81%) tumors were negative for desmin. All samples were positive for vimentin. Twenty tumors (95.2%) were positive for S-100 protein. Positivity for c-KIT was observed in four (19%) samples; COX-2 was positive in 13 (61.9%) and FeLV viral particles were positive in nine (42.9%) FISSs. Conclusions and relevance Immunohistochemical findings of FISSs revealed positive immunostainings for desmin, vimentin, S-100 protein, c-KIT, COX-2 and FeLV viral particles.
Regression patterns of choroidal melanoma: After palladium-103 (103Pd) plaque brachytherapy
Authors: Maheshwari Abhilasha , Finger Paul T 
Published: May 2018

Purpose: To describe the patterns of regression of choroidal melanoma after treatment with plaque brachytherapy. Methods: Retrospective interventional case series including 170 consecutive patients treated with 103Pd eye plaque radiation for choroidal melanoma. Outcome measures were changes in tumor thickness, surface characteristics, tumor vascularity, ultrasonography, fluorescein angiography, optical coherence tomography, and histopathology. Results: The mean initial tumor thickness was 3.9 mm (median 2.8 mm; range 2–11.3 mm) that decreased to 1.7 mm (median 1.2 mm; range 0–7.1 mm) after plaque brachytherapy. On imaging, tumors were pigmented in 51% ( n = 86/170), amelanotic in 10% ( n = 17/170), and variably pigmented in 39% ( n = 67/170). Tumor pigmentation increased in 64% ( n = 106/166), decreased in 18% ( n = 30/166), and was unchanged in 18% ( n = 30/166). Of the 120 that demonstrated intrinsic vascularity, 10% ( n = 12/120) had decreased tumor-related vascularity and 90% ( n = 108/120) showed complete resolution. Subretinal fluid was present in 34% ( n = 58/170) of eyes at presentation. Of them, 15% (9; n = 9/58) had persistent SRF at last follow-up. On ultrasound imaging, 88% ( n = 149/170) tumors presented with low to moderate internal reflectivity of which 61% ( n = 91/149) showed increased reflectivity on regression. We noted a crescendo–decrescendo fluctuation in the presence of orange pigment lipofuscin along with complete resolution of drusenoid retinal pigment epithelial detachments. In the entire series of 170 patients, there was 0.5% (1) failure of local control, 2% (4) secondary enucleations, and 6% (10) patients developing metastasis. Conclusion: Findings related to choroidal melanoma regression after 103Pd plaque brachytherapy included decreased intrinsic tumor vascularity, decreased tumor-related subretinal fluid, increased pigmentation, specific changes in orange pigment lipofuscin and resolution of drusenoid retinal pigment epithelial detachments, as well as decreased tumor thickness with an increase in internal reflectivity on ultrasound.
Emergency room visits for chronic obstructive pulmonary disease in Illinois counties: An epidemiological study based on the Social Ecological Model
Authors: McDaniel Justin T 
Published: May 2018

ObjectivesThis study aimed to determine the predictive capability of the Social Ecological Model for emergency room visits for acute exacerbation of chronic obstructive pulmonary disease.MethodsCounty-level secondary data ( n = 102) on emergency room visits for chronic obstructive pulmonary disease were retrieved from the Illinois Department of Public Health for 2016. Data for variables operationalized from the intrapersonal, interpersonal, institutional, community, and public policy levels of the Social Ecological Model were retrieved from several sources. Geographic information system software was used to examine the spatial distribution of emergency room visits for chronic obstructive pulmonary disease in Illinois. Robust linear regression analysis was used to examine significant predictors of emergency room visits for chronic obstructive pulmonary disease.ResultsA regression model with all five levels of the Social Ecological Model accounted for 50% of the variability in emergency room visits for chronic obstructive pulmonary disease, F(24,77) = 4.62, p < 0.001. Statistically significant predictors of emergency room visits for chronic obstructive pulmonary disease were observed within the interpersonal, institutional, and community levels of the Social Ecological Model.DiscussionCommunity health practitioners working to develop programs aimed at controlling chronic obstructive pulmonary disease exacerbations in Illinois should consider multiple levels of influence.
Patient-Reported Disease-Modifying Therapy Adherence in the Clinic: A Reliable Metric?
Authors: Conway Devon S , Cecilia Vieira Maria , Thompson Nicolas R , Parker Kaila N , Meng Xiangyi , Fox Robert J 
Published: May 2018

Background Adherence to multiple sclerosis (MS) disease-modifying therapy (DMT) is commonly assessed through patient reporting, but patient-reported adherence is rarely studied. Objective To determine rates of DMT adherence reported from patient to clinician, reasons for nonadherence, and relationships between adherence and outcomes. Methods We identified relapsing–remitting MS patients on DMT for ≥3 months. DMT adherence was defined as taking ≥80% of doses. Linear and logistic regression models were created used to determine the association of baseline adherence with several patient reported outcomes and the timed 25-foot walk at 6 months, 1 year, 2 years, and 3 years after the index visit. Results The analysis included 1148 patients, of whom 501 had data at 6 months, 544 at 1 year, 331 at 2 years, and 247 at 3 years. Baseline adherence was 94.9% and overall adherence was 93.1%. Forgetting was the most common reason for missed doses. In the adjusted models, adherence was not associated with the outcomes. Conclusions Higher than expected adherence and a lack of association between adherence and outcomes suggests patient reported adherence may not be reliable. Further research is needed to clarify the relationship between patient-reported adherence and relapses or new lesion formation.