bluuebunny/crossref_metadata_2025_split huggingface dataset:
Links between adolescent binge drinking and midlife alcohol use behaviors by age, sex, and race/ethnicity
Authors: Patrick Megan E. , Peterson Sarah J. , Pang Yuk C. , Terry‐McElrath Yvonne M. 
Published: October 2024

AbstractBackgroundAlcohol use is increasing among adults in midlife (i.e., ages 35–60), but few studies examine specific alcohol use behaviors in this age group. We examined measures of typical drinks, maximum drinks, binge drinking, and high‐intensity drinking by age, sex, and race/ethnicity among midlife adults, as well as the prospective association between age 18 binge drinking and midlife behaviors.MethodsData from 5180 respondents participating in the national Monitoring the Future Panel study who were aged 35–60 in 2022 (followed since they were in 12th grade in 1980–2005) were used to estimate past 30‐day midlife drinking behaviors (i.e., typical drinks, maximum drinks, binge, and high‐intensity drinking) by age group, sex, and race/ethnicity. Associations between age 18 binge drinking status and midlife drinking outcomes were examined, as well as moderation by sociodemographic characteristics.ResultsAcross ages 35–60, the mean typical number of drinks on drinking days within the past month ranged from 1.4 to 1.8; the mean maximum drinks ranged from 2.3 to 3.2. Past‐month binge and high‐intensity drinking prevalence ranged from 19.1% to 31.2% and 3.6% to 8.1%, respectively. Estimates of drinking behaviors were generally higher among respondents aged 35–40 (vs. older age groups), males (vs. females), those identifying as White (vs. other racial/ethnic groups), and those who reported age 18 binge drinking (vs. not). Adolescent binge drinking was a stronger predictor of high‐intensity drinking among females than males and of typical and maximum drinks among older (age 60) than younger (age 35) respondents.ConclusionBinge and high‐intensity drinking were reported by a meaningful percentage of the US midlife adults. Binge drinking in adolescence was a predictor of subsequent alcohol‐related risks. These long‐term connections were especially strong among females. Age 18 binge drinking was a stronger predictor of high‐intensity drinking at age 60 than earlier in midlife, underscoring that adolescent binge drinking is a key indicator of risk across the lifespan.
Capybara (Hydrochoerus hydrochaeris) Salivary Glands Morphology
Authors: Donoso Flavia María Pía Montenegro , Cristofoli Marilú , Lobão Daniel Vitor Matos , Nunes Fernanda Batistella Passos , Jorge Fabiana Morse Gosson , de Oliveira Alcobaça Mayla Magalhães , de Oliveira Radan Elvis Matias , de Assis Neto Antônio Chaves 
Published: October 2024

ABSTRACTMorphological studies concerning salivary glands have emerged as an exciting tool to understand feeding habits. In this sense, this study aimed to describe capybara salivary glands morphology to understand potential morphological associations to this species feeding habits. Macroscopic dissections and microscopic analyses were performed on eight specimens. The findings indicate that capybaras have three pairs of major (parotid, mandibular and sublingual) and two pairs of minors (dorsal and ventral buccal) salivary glands. The parotid gland, the largest, is irregularly shaped, forming small macroscopic lobes. The mandibular gland is rounded and found syntopically alongside the mandible angle and arranged medially to the ventral projection of the parotid gland. The sublingual gland is a compact elongated and semicircular mass. The dorsal and ventral buccal glands are located in the buccal portion of the buccinator muscle. Histologically, the parotid and mandibular glands are composed of serous acini, while the sublingual and buccal (dorsal and ventral) glands consist of mucous tubules containing serous demi‐lunes at their periphery. Capybara salivary glands reveal morphological associations with a predominantly herbivorous diet. The parotid gland, for example, notably developed in size and volume, suggests a specialisation for increased saliva production, necessary for chewing, forming the food bolus, swallowing fibrous foods, and protecting the oral cavity ecosystem.
Impact of HbE mutation on the clinical severity of HbH disease: A multicentre study from Thailand
Authors: Songdej Duantida , Teawtrakul Nattiya , Laoaroon Napat , Komvilaisak Patcharee , Sripornsawan Pornpun , Surapolchai Pacharapan , Hantaweepant Chattree , Tantiworawit Adisak , Hantrakool Sasinee , Lauhasurayotin Supanun , Torcharus Kitti , Sutcharitchan Pranee , Uaprasert Noppacharn , Panrong Krissana , Silpsamrit Panachai , Meekaewkunchorn Arunotai , Charoenkwan Pimlak , Pongtanakul Bunchoo ,   Red Blood Cell Disorders Study Group
Published: October 2024

SummaryHaemoglobin (Hb) H disease and HbH disease with co‐inherited HbE mutation are the most prevalent forms of α‐thalassaemia in Southeast Asia. Data were limited when comparing clinical phenotypes between these two patient groups. We conducted a Thai multicentre study and enrolled 588 patients [median (IQR) age 13.0 (6.7–20.3) years], including those with deletional HbH disease with (n = 47) and without (n = 187) co‐inherited HbE mutation and non‐deletional HbH disease with (n = 101) and without (n = 253) co‐inherited HbE mutation. Patients with HbH disease with co‐inherited HbE mutation suffered more severe manifestations than those without. This observation was more pronounced in patients with non‐deletional HbH disease. A greater proportion of patients with non‐deletional HbH disease with co‐inherited HbE mutation (43.6%) eventually required regular transfusions compared to those without (30.4%, p = 0.019). Among those with non‐deletional HbH disease who did not require regular transfusions, Hb levels were lower in patients with co‐inherited HbE mutation [8.1 (7.2–8.6) vs. 8.8 (8.2–9.5) g/dL, p < 0.001]. Among patients requiring regular transfusions who underwent splenectomy, 11/12 patients with non‐deletional HbH disease stopped transfusion compared with 1/3 in non‐deletional HbH disease with co‐inherited HbE mutation group (p = 0.024). These findings provide insights for the clinical monitoring and management of HbH disease in the region.
Crotonylation of MCM6 enhances chemotherapeutics sensitivity of breast cancer via inducing DNA replication stress
Authors: Song Haoyun , Guo Zhao , Xie Kun , Liu Xiangwen , Yang Xuguang , Shen Rong , Wang Degui 
Published: October 2024

AbstractBreast cancer is associated with high morbidity and mortality, which are closely influenced by protein post‐translational modifications (PTMs). Lysine crotonylation (Kcr) serves as a newly identified PTM type that plays a role in various biological processes; however, its involvement in breast cancer progression remains unclear. Minichromosome maintenance 6 (MCM6) is a critical component of DNA replication and has been previous confirmed to exhibit a significant role in tumorigenesis. Despite this, a comprehensive analysis of MCM6, particularly regarding its modifications in breast cancer is lacking. In this study, we found MCM6 is upregulated in breast invasive carcinoma (BRCA) and is associated with poorer overall survival by regulating the DNA damage repair mechanisms. Furthermore, MCM6‐knockdown resulted in decreased cell proliferation and inhibited the DNA replication, leading to DNA replication stress and sustained DNA damage, thereby enhancing the chemotherapeutic sensitivity of breast cancer. Additionally, SIRT7‐mediated crotonylation of MCM6 at K599 (MCM6‐K599cr) was significantly upregulated in response to DNA replication stress, primarily due to the disassemebly of the MCM2‐7 complex and regulated by RNF8‐mediated ubiquitination. Concurrently, kaempferol, which acts as a regulator of SIRT7, was found to enhance the Kcr level of MCM6, reducing tumour weight, particular when combined with paclitaxel, highlighting its potential chemotherapeutic target for BRCA therapy.
Parental Engagement in Early Childhood Education: The Case of Debre Tabor Schools, Ethiopia
Authors: Wondim Mebrat Gedfie 
Published: October 2024

ABSTRACTParental engagement (PE) in early childhood education refers to the different ways parents get involved to help children's learning. Drawing on Ecological Systems and Social Capital as theoretical frameworks, this research explored parents' engagement experiences in early childhood education in primary schools in Debre Tabor Town, Ethiopia. A qualitative approach with a case study design was employed in this study. Through purposive sampling, 12 key informants, such as parents, school principals and teachers, were chosen from five primary schools for in‐depth interviews. Thematic analysis was used to analyse data from interviews focusing on four dimensions of PE: communication, learning at home, collaborative partnership and creating a nurturing environment. Results showed that parents excelled in creating a nurturing home environment to support their children's education. However, the study revealed low engagement from parents in communication, collaborative partnership and learning at home activities. It highlighted that parents' engagement in working with others to help the education of their children was not motivating. Lastly, the study also identified the reasons behind parents' low engagement in early childhood education, many of which are associated with parent‐related, and school‐related. Generally, the research indicated parents had limited engagement in their child's pre‐school education.
Adopting Digital Tools in Higher Education: Opportunities, Challenges and Theoretical Insights
Authors: Mexhuani Burim 
Published: October 2024

ABSTRACTThe digital transformation of higher education, driven by technological advancements and evolving societal needs, presents both significant opportunities and critical challenges. This study integrates the technology acceptance model (TAM), diffusion of innovations (DOI), comprehensive literature review, in‐depth case studies and empirical survey data to explore these dynamics. The findings reveal the potential of digital technologies—such as online platforms, adaptive learning tools and immersive technologies—to expand access, personalise learning and foster collaboration. However, the research also identifies major barriers, including the digital divide, faculty resistance and data privacy concerns. By combining qualitative thematic analysis and quantitative statistical analysis, this study underscores the importance of strategic planning, inclusive policies and ongoing professional development in maximising the benefits of digital education. The paper contributes to the field by offering actionable insights, theoretical implications and practical recommendations for institutions to implement adaptive pedagogical strategies, ensure equitable access to technology and build robust, secure digital learning environments.
Long‐term cognitive outcomes after decompressive hemicraniectomy for right‐hemisphere large middle cerebral artery ischemic stroke
Authors: Scopelliti Giuseppe , Henon Hilde , Masheka‐Cishesa Olivier , Labreuche Julien , Kuchcinski Gregory , Aboukais Rabih , Cordonnier Charlotte , Casolla Barbara 
Published: October 2024

AbstractBackground and PurposeDecompressive hemicraniectomy (DH) improves survival and functional outcome in large middle cerebral artery (MCA) infarcts. However, long‐term cognitive outcomes after DH remain underexplored. In a cohort of patients with large right‐hemisphere MCA infarction undergoing DH, we assessed the rates of long‐term cognitive impairment over 3‐year follow‐up.MethodsWe prospectively evaluated consecutive patients included in the Lille Decompressive Surgery Database (May 2005–April 2022) undergoing DH according to existing guidelines for large hemisphere MCA infarction. We included patients with right‐sided stroke and screened with the Mini‐Mental State Examination (MMSE) in at least one of the prespecified follow‐ups (3‐month, 1‐year, 3‐year). Cognitive impairment was defined as an MMSE score < 24. We included only right‐hemisphere strokes to avoid testing biases related to severe aphasia. We compared clinical and neuroimaging data in patients with and without cognitive impairment.ResultsThree hundred four patients underwent DH during the study period. Among 3‐month survivors, 95 had a right‐hemisphere stroke and underwent at least one cognitive screening (median age = 51 years, 56.8% men). Forty‐four patients (46.3%) exhibited cognitive impairment at least once during the 3‐year follow‐up. Baseline characteristics did not significantly differ between patients with and without cognitive impairment. Regarding long‐term temporal trends, cognitive impairment was observed in 23 of 76 (30.3%), 25 of 80 (31.3%), and 19 of 66 (28.8%) patients at 3‐month, 1‐year, and 3‐year follow‐up, respectively, and it was associated with higher rates of functional disability (all p < 0.05).ConclusionsThe persistently high rates of cognitive impairment after DH highlight the importance of cognitive monitoring to improve the long‐term management of survivors.
Efficient and Compressed Deep Learning Model for Brain Tumour Classification With Explainable AI for Smart Healthcare and Information Communication Systems
Authors: Singh Amar , Shrivastava Rajesh Kumar , Srivastava Ashutosh 
Published: October 2024

ABSTRACTThe detection of brain tumours presents a significant challenge in the medical domain, where prompt and precise diagnosis is crucial as patient outcomes depend on it. Conventional deep neural networks perform well in carrying out various imaging tasks within the healthcare sector; however, their effectiveness often falls short of expectations in practical applications due to the substantial computational resources required and issues with reliability. In this research, an optimised and effective deep learning model founded on the DenseNet‐169 architecture is introduced for the classification of magnetic resonance imaging brain tumours, which is particularly advantageous for smart healthcare systems and information and communication technology (ICT) settings with limited computational capabilities. The model compression methodologies, including pruning and quantization, have been employed to significantly diminish the dimensions and intricacy of the model while achieving a classification accuracy of 97.07%. Furthermore, this endeavour necessitates the enhancement of the model's interpretability through the utilisation of explainable artificial intelligence methodologies such as Gradient‐weighted Class Activation Mapping (Grad‐CAM) and SHapley Additive exPlanations (SHAP), which will aid clinicians in highlighting crucial areas of the images and validating feature importance concerning the decisions rendered by the model. A comparative performance evaluation is conducted against DenseNet‐169, ResNet‐50 and various other models to delineate the superior efficacy of our model, rendering it exceptionally adept for knowledge‐driven, real‐time brain tumour diagnosis within smart healthcare and ICT systems where resources are constrained.
Mandibular third molar coronectomy in older adults and its effects on oral health‐related quality of life
Authors: Simons Rashida N. , Lindeboom Jerome A. , Tuk Jacco G. , de Lange Jan 
Published: October 2024

ObjectiveThe purpose of this study was to investigate the effect of coronectomy on postoperative quality of life in older adults.BackgroundCoronectomy is an alternative to complete surgical removal of a mandibular third molar that lies close to the inferior alveolar nerve.Materials and MethodsThis prospective study included patients >60 years old who had an indication for coronectomy of a mandibular third molar. Patients were asked to complete the Dutch version of the Oral Health Impact Profile‐14 (OHIP‐14) daily during the first postoperative week. Postoperative pain, swelling, limited mouth opening, chewing ability and infection were also recorded. Furthermore, the effect of the impaction pattern, state of eruption, presence of preoperative pathology, patient health status according to the American Society of Anaesthesiologists score, gender, smoking on the postoperative OHIP‐14 and pain scores were investigated.ResultsThirty patients (16 males, 14 females) with a mean age of 71.2 (SD 8.3, range 60–91) years were included in the study. OHIP‐14 and pain scores were highest on the first postoperative day and gradually declined during the first postoperative week. Patients who underwent coronectomy of a fully impacted mandibular third molar had significantly higher OHIP‐14 scores on the first postoperative day than those who underwent coronectomy on a (partially) erupted mandibular third molar. We did not observe any postoperative complications up to 1 year after the surgery.ConclusionMandibular third molar coronectomy seems to present a valid treatment option in older adults.
Evaluation of breast‐specific marker expression in metastatic breast cancers: Correlation with subtype switch
Authors: Chan Ronald , Leung Howard , Li Joshua , Poon Ivan , Tsang Julia Y , Ko Chun‐Wai , Wong Ngou‐Men , Tse Gary M 
Published: October 2024

AimsThis study evaluates the utility of breast specific markers in identifying breast cancer subtypes within metastatic settings. The subtype alteration in metastatic disease and its consequent impact on breast‐specific marker expression is also examined.Materials and methodsGATA‐binding protein 3 (GATA3), mammaglobin (MMG), transcriptional repressor GATA binding 1 (TRSP1) and SRY‐box transcription factor 10 (SOX10) expression were assessed in a large cohort of metastatic breast cancer (MBC) cases and correlated with the characteristics of both MBC and primary breast cancer (PBC).ResultsGATA3 was the most sensitive in MBC (83.1%), followed by TRPS1 (77.0%), MMG (58.5%) and SOX10 (7.1%). This trend was consistent in hormonal receptor (HR)+ and HR− MBC. Combining GATA3/TRPS1 yielded the highest detection rates in the overall cohort (90.1%) and HR+ MBC (97.1%), while TRSP1/MMG was most effective in HR− (76.2%) and TN (71.1%) MBC. Marker expression did not correlate with metastatic site, except SOX10 in lung metastases (P = 0.031). Subtype discordance between MBC and PBC occurred in 43 cases (24.4%), with GATA3 expression in HR− MBC significantly linked to subtype discordance (P = 0.005). Conversely, SOX10 expression was significantly associated with subtype concordance in HR− and TNBC (P ≤ 0.003). Despite a higher expression of GATA3 in all HR− cases, TRSP1 outperformed GATA3 in detecting concordant HR− cases (64.0% versus 38.5%). TRPS1 and SOX10 were expressed in more than 50% of concordant TNBC cases.ConclusionsThe expression of breast‐specific markers is mainly determined by the PBC subtype. GATA3 retains high sensitivity in HR+ cancers, even after HR loss during metastasis. TRPS1 and SOX10 are identified as valuable markers in TNBC metastasis.
Dentinal Tubule Occlusion and Dentin Permeability Efficacy of Silver Diamine Fluoride Solutions
Authors: El‐Damanhoury Hatem M. , Rahman Betul , Sheela Soumya , Ngo Hien C. 
Published: October 2024

ABSTRACTAimThis in vitro study compared the effect of two commercially available silver diamine fluoride (SDF) products on dentinal tubule (DT) occlusion and dentin permeability.MethodsSixty‐six dentin discs (1.0 mm thick) were divided equally into six groups: acid‐etched with no treatment (negative control—NC), etched and sealed with nail varnish (positive control—PC), non‐etched and treated with Advantage Arrest (AA), non‐etched and treated with Topamine (TP), etched and treated with AA, and etched and treated with TP. Eight specimens from each group were tested for permeability using the dye percolation method. The remaining three samples from each group were assessed for dentinal tubule occlusion, depth of SDF penetration, and elemental analysis using a scanning electron microscope coupled with an energy‐dispersive X‐ray (SEM/EDX) system. One‐way ANOVA and Tukey's post hoc test were used to analyze the results.ResultsTP exhibited lower (p < 0.05) dye percolation compared to AA. While both SDF materials showed a statistically similar (p > 0.05) penetration depth in the DT, none of them had the ability to completely occlude all the DTs. AA exhibited more silver and fluoride ion deposition on etched dentin than TP, and both materials showed a similar increase in the deposition of Ca and P compared to NC.ConclusionsWhereas the effectiveness of dentin tubule (DT) occlusion varies based on the material used, both tested SDF products exhibit the capability to seal dentinal tubules, decrease dentin permeability, and promote dentin remineralization. These findings suggest their potential advantage in managing dentin hypersensitivity.
The Attitude of Nursing Staff Towards Oral Healthcare for Care‐Dependent Older Adults (ANOCO) Questionnaire: Development and Validation
Authors: Palmers Ellen E. , Lambert Martijn J. , Vanobbergen Jacques , De Almeida Mello Johanna , Duyck Joke , Claessens Patricia , De Visschere Luc , Janssens Barbara 
Published: October 2024

ABSTRACTAimsThis study aims to report on the development and validation of the Attitude of Nursing staff towards Oral healthcare for Care‐dependent Older adults (ANOCO) questionnaire.MethodsThe development of the ANOCO questionnaire was performed in three stages between 2008 and 2019. In a first stage, domains related to oral healthcare attitudes were identified. Next, relevant statements per domain were formulated by a Delphi panel in two rounds, resulting in a questionnaire with 32 statements. In a final phase, this questionnaire was subjected to psychometric analysis, including an evaluation of the construct validity, an internal consistency analysis (Cronbachs alpha) and a principal component analysis.ResultsThe questionnaire could significantly distinguish between known groups (dentists, nurses' aides, nursing students and nurses). Regarding internal consistency, Cronbach's alpha was 0.863 in the first sample (n = 361) and 0.843 in the second sample (n = 1051). Based on principal component analysis, 22 statements were retained. Four components with an eigenvalue of more than 1 explained 45% of the total variance.ConclusionThe ANOCO‐22 questionnaire consists of 22 statements and is a valid tool to assess the changes or differences in the attitude of nursing staff towards oral healthcare for care‐dependent older adults.