bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclohexane, naphthalene, and diesel fuel increase oxidative stress, CYP153, sodA, and recA gene expression in Rhodococcus erythropolis
Authors: Sazykin Ivan , Makarenko Maksim , Khmelevtsova Ludmila , Seliverstova Ekaterina , Rakin Alexander , Sazykina Marina 
Published: May 2019

AbstractIn this study, we compared the expression of CYP153, sodA, sodC, and recA genes and ROS generation in hydrocarbon‐degrading Rhodococcus erythropolis in the presence of cyclohexane, naphthalene, and diesel fuel. The expression of cytochrome P450, sodA (encoding Fe/Mn superoxide dismutase), recA, and superoxide anion radical generation rate increased after the addition of all studied hydrocarbons. The peak of CYP153, sodA, and recA gene expression was registered in the presence of naphthalene. The same substrate upregulated the Cu/Zn superoxide dismutase gene, sodC. Cyclohexane generated the highest level of superoxide anion radical production. Hydrogen peroxide accumulated in the medium enriched with diesel fuel. Taken together, hydrocarbon biotransformation leads to oxidative stress and upregulation of antioxidant enzymes and CYP153 genes, and increases DNA reparation levels in R. erythropolis cells.
Hydrangea serrata Tea Enhances Running Endurance and Skeletal Muscle Mass
Authors: Jang Young Jin , Ahn Jisong , Son Hyo Jeong , Jung Chang Hwa , Ahn Jiyun , Ha Tae Youl 
Published: May 2019

ScopeSkeletal muscle mass and quality can be negatively affected by aging, inactivity, and disease, while a loss of muscle mass is associated with chronic disease status, falls, and mortality. We investigate the effects of Hydrangea serrata on skeletal muscle mass and function, along with the underlying mechanisms.Methods and resultsH. serrata, identified through MyoD transcription activity screening, increases myogenic differentiation via Akt and p38. C57BL/6 mice are fed a 0.25% or 0.5% H. serrata diet for 8 weeks. H. serrata increased treadmill running distance and maximum speed, as well as skeletal muscle mass. H. serrata promotes the expression of myosin heavy chain 1 (MHC1) and MHC2A but not MHC2B. H. serrata also upregulates the protein expression of peroxisome proliferator‐activated receptor δ (PPARδ) and mitochondrial complexes, and enhances citrate synthase and mitochondrial complex І activity. Transforming growth factor‐β (TGF‐β), myostatin, and growth differentiation factor 11 (GDF11) are attenuated by H. serrata, together with associated downstream signaling factors including phospho‐Smad3 and NADPH oxidase 4 (NOX4).ConclusionH. serrata enhances exercise endurance by upregulating PPARδ and downregulating TGF‐β, myostatin, and GDF11. H. serrata is a potential candidate for the development of functional food to maintain skeletal muscle mass and function.
Long‐wavelength infrared characteristics of multifunctional microfibrous thin films of Parylene C
Authors: Chandraprakash C. , Venugopal Vijayakumar C. , Lakhtakia Akhlesh , Awadelkarim Osama O. 
Published: May 2019

AbstractCalculations show that structurally chiral, three‐dimensionally periodic, microfibrous thin films (μFTFs) of Parylene‐C can function as both polarization‐insensitive and circular‐polarization‐selective photonic crystals in the long‐wavelength infrared regime. Careful engineering is required for bandstop filters in order to avoid the numerous absorption peaks of bulk Parylene‐C. The photonic functionality of the Parylene‐C μFTFs is in addition to their phononic, hydrophobic, and biomedical functionalities.
Design and analysis of m‐segment fractal boundary antennas
Authors: Jayasinghe Jeevani , Saraereh Omar , Khokle Rajas , Esselle Karu 
Published: May 2019

AbstractThis article investigates the resonant behavior of a novel family of fractal boundary antennas at the fundamental mode of operation. The miniaturization patterns over iterations as well as over the number of segments on the boundary have been studied by simulating the fractal antennas in High Frequency Structure Simulator (HFSS). The antennas are fed by a 50‐Ω coaxial probe, which is placed at the best position on the patch, with impedance matching and S11 < −10 dB. Analysis of the resonant frequency with respect to the square‐shaped fractal generator resulted in curve‐fit expressions that vary with a single variable of either iteration or number of segments on the boundary. The derived equations are independent from the substrate thickness. They are useful to design miniature patch antennas within a specified area in order to resonate at a desired frequency by simply changing the boundary or the fractal iteration.
Fatty Acid Binding to Human Serum Albumin in Blood Serum Characterized by EPR Spectroscopy
Authors: Haeri Haleh H. , Schunk Bettina , Tomaszewski Jörg , Schimm Heike , Gelos Marcos J. , Hinderberger Dariush 
Published: May 2019

AbstractOne of the functions of Human Serum Albumin (HSA) is binding and transport of fatty acids. This ability could be altered by the presence of several blood components such as toxins or peptides – which in turn alters the functionality of the protein. We aim at characterizing HSA and its fatty acid binding in native serum environment. Native ligand binding and deviations from normal function can be monitored by electron paramagnetic resonance (EPR) spectroscopy using spin labeled fatty acids (FAs). Blood serum from healthy individuals is used to examine healthy HSA in its natural physiological conditions at different loading ratios of protein to FAs. Among the EPR spectroscopic parameters (like hyperfine coupling, line shape, rotational correlation time and population of different binding sites) the rotational correlation time is found to differ significantly between binding sites of the protein, especially at loading ratios of four FAs per HSA. Although differences are observed between individual samples, a general trend regarding the dynamics of healthy HSA at different loading ratios could be obtained and compared to a reference of purified commercially available HSA in buffer.
Nonparametric cost‐minimized Shewhart‐type process monitoring with restricted false alarm probability
Authors: Li Chenglong , Mukherjee Amitava 
Published: May 2019

AbstractTraditional Duncan‐type models for cost‐efficient process monitoring often inflate type I error probability. Nevertheless, controlling the probability of type I error or false alarms is one of the key issues in sequential monitoring of specific process characteristics. To this end, researchers often recommend economic‐statistical designs. Such designs assign an upper bound on type I error probability to avoid excessive false alarms while achieving cost optimality. In the context of process monitoring, there is a plethora of research on parametric approaches of controlling type I error probability along with the cost optimization. In the nonparametric setup, most of the existing works on process monitoring address one of the two issues but not both simultaneously. In this article, we present two distribution‐free cost‐efficient Shewhart‐type schemes for sequentially monitoring process location with restricted false alarm probability, based, respectively, on the sign and Wilcoxon rank‐sum statistics. We consider the one‐sided shift in location parameter in an unknown continuous univariate process. Nevertheless, one can easily extend our proposed schemes to monitor the two‐sided process shifts. We evaluate and compare the actual performance of the two monitoring schemes employing extensive computer simulation based on Monte Carlo. We investigate the effects of the size of the reference sample and the false alarm constraint. Finally, we provide two illustrative examples, each based on a realistic situation in the industry.
Ten complementary measures to assist with environmental watering programs in the Murray–Darling river system, Australia
Authors: Baumgartner Lee J. , Gell Peter , Thiem Jason D. , Finlayson Colin (Max) , Ning Nathan 
Published: May 2019

AbstractRestoration programmes for degraded aquatic ecosystems frequently focus on flow restoration or reinstatement, including recovery targets for volumes of water to be used for environmental benefit. Australia's Murray–Darling Basin is an example of a major system undergoing substantial water reform to balance the needs of competing users, including the environment, within the constraints of an arid climate. This reform revolves around accounting for finite volumes of water that have been shared amongst water users. We argue that while recovering water will provide good outcomes, as a sole intervention, it is not enough to deliver the desired environmental benefits of the reform given the significantly altered state of the catchment. Here, we present 10 measures that could be used to complement planned water recovery actions. These “complementary measures” integrate recovery actions, which when strategically combined with water delivery would significantly enhance water reform efforts to generate environmental outcomes in a highly modified system.
The Influence of Structural Variations on the Heteroacenes Containing Dihydropyrrolo[3,2‐b]pyrrole Core on Their OFET Performances
Authors: Wang Xiao , Wang Hanlin , Li Chenchen , Qiu Li , Liu Yunqi , Li Liang , Wan Xiaobo 
Published: May 2019

AbstractHeteroacenes containing a dihydropyrrolo[3,2‐b]pyrrole core such as 5,10‐dihydroindolo[3,2‐b]indole (DBPP) and dinaphtho [2,3‐b:2’,3’‐f]pyrrolo[3,2‐b]pyrrole(DNPP) are potential p‐type semiconductors for organic field‐effect transistors (OFETs) owing to their electron‐rich and easy‐to‐modify core structure. Here we report that how the structural variations such as ring fusion pattern, heteroatom introduction and chlorination influence the crystallinity, orientation and morphology of this type of heteroacenes hence their OFET performance. It is revealed that angular fused C8‐iso‐DNPP has a higher HOMO energy level with matches better with the work‐function of Au and shows better crystallinity and more uniformed morphology compared to the linearly fused isomer C8‐DNPP. Thus it exhibits very similar hole mobility to C8‐DNPP but much smaller threshold voltages. On the other hand, the introduction of extra N atoms into DNPP affords an analogue DQPP and greatly alters the orientation of the crystalline film from “edge‐on” to “face‐on”, which results in a two‐order decrease of the hole mobility. Our result also shows that heavily chlorinated DBPP (TClDBPP) leads to the completely loss of the hole transport capability due to the large π‐π distance imposed by the large chlorine atoms.
aUse of Epichlorohydrin as a New, Inexpensive and Highly Efficient Linker for Magnetization of Nano‐metal Oxides: The Extension of using a Covalent Linker as a Third Methodology
Authors: Bitaraf Mehrnoosh , Amoozadeh Ali 
Published: May 2019

AbstractEpichlorohydrin has been successfully used for coupling nano metal oxides by covalent linkage. Applying this method, a highly efficient and magnetically separable catalyst was synthesized using n‐Fe3O4 and n‐TiO2. This approach is the extension of the third methodology for magnetization of nanoparticles. Stability and catalytic properties of the novel catalyst was investigated by Fourier transform infrared spectroscopy (FT‐IR), field emission scanning electron microscopy (FE‐SEM), thermogravimetric analysis (TGA), X‐ray diffraction (XRD) and vibrating sample magnetometer (VSM). Also, the catalytic activity and selectivity were tested for the oxidation reaction of sulfides to sulfoxides. The catalyst exhibited superior recyclability and reusability. It accomplished six consecutive runs, thoroughly with negligible loss of activity.
Directing Gold Nanoparticles into Free‐Standing Honeycomb‐Like Ordered Mesoporous Superstructures
Authors: Wu Xiaotong , Chen Jinping , Xie Lin , Li Jing , Shi Jing , Luo Shuiping , Zhao Xixia , Deng Kerong , He Dongsheng , He Jiaqing , Luo Jun , Wang Zhongwu , Quan Zewei 
Published: May 2019

Abstract2D mesoporous materials fabricated via the assembly of nanoparticles (NPs) not only possess the unique properties of nanoscale building blocks but also manifest additional collective properties due to the interactions between NPs. In this work, reported is a facile and designable way to prepare free‐standing 2D mesoporous gold (Au) superstructures with a honeycomb‐like configuration. During the fabrication process, Au NPs with an average diameter of 5.0 nm are assembled into a superlattice film on a diethylene glycol substrate. Then, a subsequent thermal treatment at 180 °C induces NP attachment, forming the honeycomb‐like ordered mesoporous Au superstructures. Each individual NP connects with three neighboring NPs in the adjacent layer to form a tetrahedron‐based framework. Mesopores confined in the superstructure have a uniform size of 3.5 nm and are arranged in an ordered hexagonal array. The metallic bonding between Au NPs increases the structural stability of architected superstructures, allowing them to be easily transferred to various substrates. In addition, electron energy‐loss spectroscopy experiments and 3D finite‐difference time‐domain simulations reveal that electric field enhancement occurs at the confined mesopores when the superstructures are excited by light, showing their potential in nano‐plasmonic applications.
Active Self‐Assembly of Train‐Shaped DNA Nanostructures via Catalytic Hairpin Assembly Reactions
Authors: Xing Chao , Dai Junduan , Huang Yuqing , Lin Yuhong , Zhang Kai‐Long , Lu Chunhua , Yang Huanghao 
Published: May 2019

AbstractBiomolecular self‐assembly is a powerful approach for fabricating supramolecular architectures. Over the past decade, a myriad of biomolecular assemblies, such as self‐assembly proteins, lipids, and DNA nanostructures, have been used in a wide range of applications, from nano‐optics to nanoelectronics and drug delivery. The method of controlling when and where the self‐assembly starts is essential for assembly dynamics and functionalization. Here, train‐shaped DNA nanostructures are actively self‐assembled using DNA tiles as artificial “carriages,” hairpin structures as “couplers,” and initiators of catalytic hairpin assembly (CHA) reactions as “wrenches.” The initiator wrench can selectively open the hairpin couplers to couple the DNA tile carriages with high product yield. As such, DNA nanotrains are actively prepared with two, three, four, or more carriages. Furthermore, by flexibly modifying the carriages with “biotin seats” (biotin‐modified DNA tiles), streptavidin “passengers” are precisely arranged in corresponding seats. The applications of the CHA‐triggered self‐assembly mechanism are also extended for assembling the large DNA origami dimer. With the creation of 1D architectures established, it is thought that this CHA‐triggered self‐assembly mechanism may provide a new element of control for complex autonomous assemblies from a variety of starting materials with specific sites and times.
Long‐Term Outcome After Conventional Two‐Stage Hepatectomy Versus Tourniquet‐ALPPS in Colorectal Liver Metastases: A Propensity Score Matching Analysis
Authors: Robles‐Campos Ricardo , Brusadin Roberto , López‐Conesa Asunción , López‐López Víctor , Navarro‐Barrios Álvaro , López‐Espín José J. , Arévalo‐Pérez Julio , Parrilla Pascual 
Published: May 2019

AbstractBackgroundTo compare the overall survival (OS) and disease‐free survival (DFS) of Tourniquet‐ALPPS (T‐ALPPS) and conventional two‐stage hepatectomy (TSH) in patients with colorectal liver metastases (CRLM).MethodsA retrospective study from a prospectively collected database was performed between October 2000 and July 2016. TSH was performed before September 2011, after which time T‐ALPPS became the technique of choice. A propensity score matching (PSM) was performed based on a 1:1 ratio with consideration of the following variables: number and size of metastases, bilobar disease presence, and chemotherapy received.ResultsThirty‐four patients received T‐ALPPS; 41 patients received TSH. After PSM, 21 patients remained in each group, with 100% resectability in the T‐ALPPS group and 90.5% resectability in the TSH group. The median OS for TSH was 41 months; for T‐ALPPS, the median OS was 36 months (P = 0.925). The median DFS was 16 months in the TSH group; the median DFS was 9 months in the T‐ALPPS group (P = 0.930). The 1‐, 3‐, and 5‐year OS for TSH was 81%, 66.7%, and 23.8% vs. 76.2%, 57.1%, and 22.9% for T‐ALPPS, respectively. The 1‐, 3‐, and 5‐year DFS for TSH was 66.7%, 9.5%, and 5% vs. 44.6%, 11.1%, and 11.1% for T‐ALPPS, respectively. The volume increase with T‐ALPPS was superior to that with TSH (68% vs. 39%; P = 0.018). There were no differences in morbidity and mortality after stages 1 and 2.ConclusionsT‐ALPPS produces a similar outcome to TSH, indicating that it could be a safe and effective alternative for curative hepatectomy for all patients.
Removing Depth-Order Cycles Among Triangles: An Algorithm Generating Triangular Fragments
Authors: de Berg Mark 
Published: May 2019

AbstractMore than 25 years ago, inspired by applications in computer graphics, Chazelle et al. studied the following question: is it possible to cut any set of n lines or other objects in $${\mathbb R}^3$$

R

3

into a subquadratic number of fragments such that the resulting fragments admit a depth order? They managed to prove an $$O(n^{9/5})$$

O
(

n

9
/
5

)

bound on the number of fragments, but only for the very special case of bipartite weavings of lines. Since then only little progress was made, until a breakthrough in 2016 by Aronov and Sharir, who showed that $$O(n^{3/2}{{\,\mathrm{polylog}\,}}n)$$

O
(

n

3
/
2

polylog

n
)

fragments suffice for any set of lines. In a follow-up paper Aronov et al. proved an $$O(n^{3/2+\varepsilon })$$

O
(

n

3
/
2
+
ε

)

bound for triangles, but their method uses high- (albeit constant-) degree algebraic arcs to perform the cuts. Hence, the resulting pieces have curved boundaries. Thus the following natural version of the problem is still wide open: is it possible to cut any collection of n disjoint triangles in $${\mathbb R}^3$$

R

3

into a subquadratic number of triangular fragments that admit a depth order? And if so, can we compute the cuts efficiently? We answer this question by presenting an algorithm that cuts any set of n disjoint triangles in $${\mathbb R}^3$$

R

3

into $$O(n^{7/4}{{\,\mathrm{polylog}\,}}n)$$

O
(

n

7
/
4

polylog

n
)

triangular fragments that admit a depth order. The running time of our algorithm is $$O(n^{3.69})$$

O
(

n

3.69

)

. We also prove a refined bound that depends on the number, K, of intersections between the projections of the triangle edges onto the xy-plane: we show that $$O(n^{1+\varepsilon } + n^{1/4} K^{3/4}{{\,\mathrm{polylog}\,}}n)$$

O
(

n

1
+
ε

+

n

1
/
4

K

3
/
4

polylog

n
)

fragments suffice to obtain a depth order. This result extends to xy-monotone surface patches bounded by a constant number of bounded-degree algebraic arcs in general position, constituting the first subquadratic bound for surface patches.
Initial coin offerings (ICOs): market cycles and relationship with bitcoin and ether
Authors: Masiak Christian , Block Joern H. , Masiak Tobias , Neuenkirch Matthias , Pielen Katja N. 
Published: May 2019

Abstract
We apply a vector autoregression (VAR) model to investigate the market cycles of Initial Coin Offerings (ICOs) as well as their relationships with bitcoin and ether. Our sample covers 104 weekly observations between January 2017 and December 2018. Our results show that ICO market cycles exist and that shocks to the growth rates of ICO volumes are persistent. In addition, shocks in cryptocurrency returns have a substantial and positive effect on ICO volumes. In contrast, the volatility of cryptocurrency returns does not significantly affect ICO volumes. Our results are robust to using (i) the number of successfully completed ICO campaigns instead of ICO volumes and (ii) ICO data from a different data source. Our study has implications for financial practice, in particular for cryptocurrency investors and entrepreneurial firms conducting ICOs.
Teleology and mentalizing in the explanation of action
Authors: Peters Uwe 
Published: May 2019

AbstractIn empirically informed research on action explanation, philosophers and developmental psychologists have recently proposed a teleological account of the way in which we make sense of people’s intentional behavior. It holds that we typically don’t explain an agent’s action by appealing to her mental states but by referring to the objective, publically accessible facts of the world that count in favor of performing the action so as to achieve a certain goal. Advocates of the teleological account claim that this strategy is our main way of understanding people’s actions. I argue that common motivations mentioned to support the teleological account are insufficient to sustain its generalization from children to adults. Moreover, social psychological studies, combined with theoretical considerations, suggest that we do not explain actions mainly by invoking publically accessible, reason-giving facts alone but by ascribing mental states to the agent.
Test-Retest Measurement Invariance of the Nine-Item Internet Gaming Disorder Scale in Two Countries: A Preliminary Longitudinal Study
Authors: Stavropoulos Vasileios , Bamford Luke , Beard Charlotte , Gomez Rapson , Griffiths Mark D. 
Published: May 2019

AbstractThe reliable longitudinal assessment of Internet Gaming Disorder (IGD) behaviors is viewed by many as a pivotal clinical and research priority. The present study is the first to examine the test-retest measurement invariance of IGD ratings, as assessed using the short-form nine-item Internet Gaming Disorder Scale (IGDS9-SF) over an approximate period of 3 months, across two normative national samples. Differences referring to the mode of the data collection (face-to-face [FtF] vs. online) were also considered. Two sequences of successive multiple group confirmatory factor analyses (CFAs) were calculated to longitudinally assess the psychometric properties of the IGDS9-SF using emergent adults, gamers from (i) the United States of America (USA; N = 120, 18–29 years, Meanage = 22.35, 51.6% male) assessed online and; and (ii) Australia (N = 61, 18–31 years, Meanage = 23.02, 75.4% male) assessed FtF. Configural invariance was established across both samples, and metric and scalar invariances were supported for the USA sample. Interestingly, only partial metric (factor loadings for Items 2 and 3 non-invariant) and partial scalar invariance (i.e., all thresholds of Items 1 and 2, and thresholds 1, 3, for Items 4, 6, 8, and 9 non-invariant) were established for the Australian sample. Findings are discussed in the light of using IGDS9-SF to assess and monitor IGD behaviors over time in both in clinical and non-clinical settings.