bluuebunny/crossref_metadata_2025_split huggingface dataset:
A MODIFIED MODEL BASED ON FLOWER POLLINATION ALGORITHM AND K-NEAREST NEIGHBOR FOR DIAGNOSING DISEASES
Authors: Zekriyapanah Gashti Mehdi 
Published: June 2018

Exponential growth of medical data and recorded resources from patients with different diseases can be exploited to establish an optimal association between disease symptoms and diagnosis. The main issue in diagnosis is the variability of the features that can be attributed for particular diseases, since some of these features are not essential for the diagnosis and may even lead to a delay in diagnosis. For instance, diabetes, hepatitis, breast cancer, and heart disease, that express multitudes of clinical manifestations as symptoms, are among the diseases with higher morbidity rate. Timely diagnosis of such diseases can play a critical role in decreasing their effect on patientsâ€™ quality of life and on the costs of their treatment. Thanks to the large data set available, computer aided diagnosis can be an advanced option for early diagnosis of the diseases. In this paper, using a Flower Pollination Algorithm (FPA) and K-Nearest Neighbor (KNN), a new method is suggested for diagnosis. The modified model can diagnose diseases more accurately by reducing the number of features. The main purpose of the modified model is that the Feature Selection (FS) should be done by FPA and data classification should be performed using KNN. The results showed higher efficiency of the modified model on diagnosis of diabetes, hepatitis, breast cancer, and heart diseases compared to the KNN models. ABSTRAK: Pertumbuhan eksponen dalam data perubatan dan sumber direkodkan daripada pesakit dengan penyakit berbeza boleh disalah guna bagi membentuk kebersamaan optimum antara simptom penyakit dan mengenal pasti gejala penyakit (diagnosis). Isu utama dalam diagnosis adalah kepelbagaian ciri yang dimiliki pada penyakit tertentu, sementara ciri-ciri ini tidak penting untuk didiagnosis dan boleh mengarah kepada penangguhan dalam diagnosis. Sebagai contoh, penyakit kencing manis, radang hati, barah payudara dan penyakit jantung, menunjukkan banyak klinikal simptom jelas dan merupakan penyakit tertinggi berlaku dalam masyarakat. Diagnosis tepat pada penyakit tersebut boleh memainkan peranan penting dalam mengurangkan kesan kualitiÂ hidup dan kos rawatan pesakit. Terima kasih kepada set data yang banyak, diagnosis dengan bantuan komputer boleh menjadi pilihan maju menuju ke arah diagnosis awal kepada penyakit. Kertas ini menggunakan Algoritma Flower Pollination (FPA) dan K-Nearest Neighbor (KNN), iaitu kaedah baru dicadangkan bagi diagnosis. Model yang diubah suai boleh mendiagnosis penyakit lebih tepat dengan mengurangkan bilangan ciri-ciri. Tujuan utama model yang diubah suai ini adalah bagi Pemilihan Ciri (FS) perlu dilakukan menggunakan FPA and pengkhususan data perlu dijalankan menggunakan KNN. Keputusan menunjukkan model yang diubah suai lebih cekap dalam mendiagnosis penyakit kencing manis, radang hati, barah payudara dan penyakit jantung berbanding model KNN.
THE PREDICTORS OF HOSPITALIZATION IN HEMODIALYSIS PATIENTS
Authors: Dudar I. , Gonchar Y. , Savchuk V. 
Published: June 2018

Summary. The aim of the present research was to identify predictors of hospitalization hemodialysis (HD) patients.
Materials and methods. The study involved 186 HD patients (49,38±0,94 у.) between Jan 2013 and Jan 2014. We studied the evolution of laboratory and treatment parameters, including dry body-weight, ultrafiltration, mean blood pressure, plasma albumin, Hb, absolute lymphocyte count, absolute neutrophil count, neutrophil-to-lymphocyte ratio, “hemoglobin variability ” all patients. The HD patients were divided for 2 groups: I group of outpatients (n=103), II group of hospitalized patients (n=83). Data from 83 hospitalized patients were compared with non-hospitalized patients. Laboratory and treatment parameters were assessed at least 3 months prior to admission.
Results. We found that hospitalization was 45,29±4,20 days, frequency of hospitalization 1,46±0,07. The likelihood of frequency and duration a hospitalization increased with patient age (p<0,05). Hospitalizations were preceded by a decrease level albumin, a decline in Hb concentration, a decrease absolute lymphocyte count, increase in the neutrophil-to-lymphocyte ratio, a reduction ultrafiltration.
The hozpitalization of patients with “stable hemoglobin ” was significantly lower than in patients with “low of hemoglobin variability”(p<0,005).
Conclusions. Patients whose noted these parameters should be monitored, thus, it may be useful to identify risk factors for hospitalization.
EVALUATIONOFRENAL REPLACEMENT THERAPYQUALITY IN UKRAINE: TIME FOR ACTIONS
Authors: Kolesnyk Mykola , Kozlyuk Nadiya 
Published: June 2018

Background. Little is known about the status of renal replacement therapy (RRT) in the post-Soviet period of Ukraine. We therefore investigated the epidemiology and treatment outcomes of RRT in Ukrainian patients and put the results into an international perspective.
Methods. Data from the Ukrainian National Renal Registry for patients on RRT between 1 January 2010 and 31 December 2012 were selected. We calculated the incidence and prevalence of RRT per million population (pmp) and the 3-, 12- and 24-month patient survival using the Kaplan— Meier method and Cox regression
Results. There were 5985prevalent patients on RRT on 31 December 2012 (131,2 pmp). Mean age was 46,5 ± 13,8 years, 56% were men and 74% received haemodialysis (HD), while peritoneal dialysis and kidney transplantation both represented 13%. The most common cause of end-stage renal disease was glomerulonephritis (51%), while only 12% had diabetes. In 2012, 1129 patients started dialysis (incidence 24,8 pmp), with 80% on HD. Mean age was 48 ± 14 years, 58% were men and 20% had diabetes. Three, 12- and 24-month patient survival on dialysis was 95,1%, 86,0% and 76,4%, respectively. The transplant rate in 2012 was 2,1 pmp.
Conclusions. The incidence and prevalence of RRT and the transplantation rate in Ukraine are among the lowest in Europe, suggesting that the need for RRT is not being met. Strategies to reduce the RRT deficit include the development and improvement of transplantation and home-based dialysis programs. Further evaluation of the quality of Ukrainian RRT care is needed.
ANTIMICROBIAL RESISTANCE OF GRAM POSITIVE BACTERIA ISOLATED LNPATLENTS WLTHCHRONLCKLDNEYDLSEASSTAGE5D: PREVALENCE AND OUTCOMES
Authors: Shifris І.М. , Dudar I.O. , Krot V.F. , Kruglikov V.T. , Aleksieva N.G. , Nechyporuk T.N. , Grigorieva Е. М. 
Published: June 2018

Bacterial infections in chronic kidney disease stage VD (CKD VD st.)patients are associated with increased risk of hospitalization and death.

The aim was to study of opportunistic pathogenic bacteria spectrum, their antibacterial resistance and the correlation between carriage and hospitalization and mortality rate in adult patients with CKD V D st.
Materials and methods. This prospective cohort, open-label, randomized, two-phase study included 146 patients with CKD V D st., 118 of whom were treated by hemodialysis (HD) and 28 by peritoneal dialysis (PD). The microbiological screening was conducted in the first stage. The examined material was throat/nose swabs and wet smears from skin of dialysis access site. On the second stage all patients were randomized on two groups: the group 1 (n=61) included patients with identified MRSA / VRE colonization and group 2 (n=85) included patients with colonization of other strains of opportunistic pathogenic bacteria. The groups were representative according to gender, age, type of kidney affections and renal replacement therapy (RRT) modality. The microbiological examination consisted of inoculation of hard medium by examined material. The end points were total amount of hospitalization and death events evaluated for 24 months after randomization.
Results. The colonization of some biotype of opportunistic pathogenic bacteria was established in 100% ofpatients. In total were isolated 347 strains of gram-positive bacteria: 284 and 63 in HD and PD patients, respectively. Without statistical significance approximately 20% of microorganism strains were resistant to 10 and more antibiotics according to dialysis modality. The MRSA colonization was identified in 49 (33.6%) patients (37/31.4% and 12/42.9% of HD u PD patients, respectively; p=0,246). The VRE colonization was established in 12 patients (10/8.5% and 2/7.1% of HD and PD patients, respectively; p=0.81).
The 70 hospitalization episodes were recorded during monitoring period. The significant majority was established in group 1 of patients (39/64% vs. 31/36.5 %; %2 =10.733, p=0,001) irrespective ofRRTmodality. The specific share ofdead persons in group 1 was in three times more than such share in group 2 (9/14.8% vs. 4/4.7 %; %2=4.42, p= 0.0355). The relative risks of hospitalization and death in the presence of MRSA/VRE colonization increased in 1.75 (95% CI: 1.252.5) and 3.14(95% CI: 1.01-9.7) times.
Conclusion. In this study was demonstrated that MRSA/VRE colonization in adult patients with CKD V D st. is a risk marker and a predictor of negative clinical prognosis. The RRT modality hadn’t significant effect on rate of negative consequences, particularly on rate of hospitalization and death in population of CKD V D st. patients.
EVALUATION OF THE MICROBIAL PROFILE AND ANTIBIOTIC RESISTANCE OF BACTERIA CAUSING URINARY TRACT INFECTION IN THE CHILDREN OF KYIV REGION
Authors: Lavrenchuk О. , Bagdasarova І. 
Published: June 2018

The rapid growth of the acquired resistance of bacteria to antibacterial agents requires a revision of the selection ofempirical antimicrobial therapy in children with urinary tract infection (UTI).
The aim of this work was to investigate the etiological structure of uropathogen flora and its sensitivity to nitrofurantoin and antibacterial drugs ofother classes in children with UTI in Kyiv and region.
Materials and methods. Were examined in 95 children aged 3 to 17years in the aediatric Nephrology Department of, Institute of Nephrology NAMS of Ukraine” on the basis of clinical hospital №7 Kyiv city in 2015-2016. The disease duration ofthepatients rangedfrom 3 months to 4years.
Results.The microbial spectrum of the urine depended on theform of pyelonephritis, but all patients were dominated by enterobacteria E. coli and Kl. pneumoniae. The greatest number of patients was resistant to ampicillin, co-trimoxazol and cefuroxime – 10.5% of patients with acute and 17.2% with chronic pyelonephritis. The highest sensitivity was preserved in all patients before medications meronem and gentamicin – 100% and 94.7%, respectively. Most children in Kyiv and Kyiv region showed a high sensitivity to nitrofurantoin:furamag – 78.9-75.8%,furagin - 63.8-65.5%. Comparative analysis of therapeutic efficiency of drugsfuramag and co-trimoxazol, demonstrated greater therapeutic efficacy of nitro- furans in the absence of recurrences, compared with co-trimoxazol (Oto 1.68withp=0.021).
Conclusions. Among the causative agents of UTI in children of the city of Kyiv and Kyiv region was dominated by gram-negativeflora - E. coli and Kl. pneumoniae. High sensitivity to nitrofurantoin drugs, especiallyfuramag, cephalosporins, and gentamicin and meronem was documented. High rates of resistance to penicillin and co-trimoxazol was revealed. The use of the drugfuramag contributed to a more rapid, complete andpersistent normalization ofclinical and laboratory parameters in children with UTI.
HOSPITAL MORBIDITYINPATIENTS WITH CHRONICKIDNEYDISEASE STAGE UD
Authors: Shifris І. , Krot V. , Gonchar Y. , Krasyuk E. , Dudar I. 
Published: June 2018

According to opinion of European researchers the expenses, associated with in–patient treatment, constitutes the significant part of health service expenditure in population of patients on renal replacement therapy (RRT). Only in few studies the hospitalization levels were compared for population ofpatients on hemodialysis (HD) and peritoneal dialysis (PD).
Aim. The aim of this study was analysis the hospital morbidity pattern in patients with CKD stage 5D on HD and PD.
Materials and methods. It was performed the retrospective (for period 01 Jan to 31 Dec 2013) analysis of hospitalization structure and rate for patients, were treated by RRT. All hospitalization admissions were assessed in view of modality and duration of RRT, demographic/gender characteristics, and renal affection type. In 2013 the RRT treatment were provided to 351 patients, including the 296 on HD and 55 on PD.
Results. Overall 173 cases of hospitalization were recorded, including 142 (82,08%) primary and 31 (17,92%) readmissions. Irrespective of RRT modality the three most common causes of hospitalization were cardiovascular diseases (CVD), bacterial infections, and anemia. 41 hospitalization was caused by RRT initiation (28 HD and 13 PD), the most
of patients aged 45 years and older. The hospitalization rate in PD patients with was significantly higher than in patients on HD: 70,9±6,1% vs. 34,8±2,8%, respectively;p<0,0001. The duration of hospitalization was significantly higher by HD– than PD patients (30,09±17.21 vs. 21.82±10.56, respectively; p=0,0007).

Conclusions. During follow–up, at least one hospitalization had more than 40%patients with CKD stage 5D. In HD patients the most common causes of hospitalization were bacterial infections, CVD and anemia. Anemia, CVD and bacterial infections were the most frequent causes hospitalization in PD patients.
Pengaruh Pengembangan Karir dan Budaya Organisasi terhadap Kinerja Melalui Kepuasan Kerja Guru Sekolah Kebangsaan Kebun Sireh Pulau Pinang
Authors: Rusby Zulkifli , Hamzah Zulfadli 
Published: June 2018

Human resource plays important role and the most dominant factors in organization. Employee performance can be measured by various indicators, one of which is job satisfaction. This research employs descriptive approach with collected primary and secondary data in describing the effect of carrier development and culture organization on teacher performance through job satisfaction. The population of this research include all teacher are 46 respondent. Data analysis technique use path analysis. The result of this research found that carrier development through job satisfaction indirectly has positive influence or significance toward teacher performance. Besides that, organizational culture through job satisfaction indirectly also has positive influence or significance toward teacher performance.
Keywords: Carrier Development,Organizational Culture,Performance,Job Satisfaction, Path Analysis
Hubungan Pola Makan dengan Kejadian Anemia pada Ibu Hamil di Wilayah Kerja Puskesmas
Authors: Mariana Dina , Wulandari Dwi , Padila Padila 
Published: June 2018

This study aims to determine the relationship between diet and the incidence of anemia in pregnant women in Puskesmas Jalan Gedang Kota Bengkulu. Based on the preliminary study conducted on 10 people pregnant women in the work area of ​​gedang puskesmas got 5 mother mother had pregnancy anemia in trimester 1 and 2I, when asked this matter because of the food menu that potluck.The study method used was a descriptive analytic cross sectional design. This studywas conducted in Jalan Gedang health center Bengkulu City from March 1 until May 1, 2017, with the samples of 30 respondents. Retrieving data was done using a questionnaire sheet and documentation of patient status and then analyzed by univariate and bivariate using Chi Square test. Results of the 30 respondents were half of the respondents 50.0% had unhealthy eating patterns, almost half of respondents 26.7% had anemia. Based on Chi-Square test pvalue 0.035, which shows there was a correlation between the diet and the incidence of anemia among pregnant women in Jalan Gedang health center Bengkulu City.
Keywords: Anemia of Pregnant Women, Diet,
Risk of subsequent stroke, with or without extracranial-intracranial bypass surgery: a nationwide, retrospective, population-based study
Authors: Chen XianXiu , Lin Cheng-Li , Su Yuan-Chih , Chen Kuan-Fei , Lai Shih-Wei , Wei Sung-Tai , Peng Ching-Tien , Chiu Cheng-Di , Shieh Shwn-Huey , Chen Chun-Chung 
Published: June 2018

OBJECTIVEAlthough no benefits of extracranial-intracranial (EC-IC) bypass surgery in preventing secondary stroke have been identified previously, the outcomes of initial symptomatic ischemic stroke and stenosis and/or occlusion among the Asian population in patients with or without bypass intervention have yet to be discussed. The authors aimed to evaluate the subsequent risk of secondary vascular disease and cardiac events in patients with and without a history of this intervention.METHODSThis retrospective nationwide population-based Taiwanese registry study included 205,991 patients with initial symptomatic ischemic stroke and stenosis and/or occlusion, with imaging data obtained between 2001 and 2010. Patients who underwent EC-IC bypass (bypass group) were compared with those who had not undergone EC-IC bypass, carotid artery stenting, or carotid artery endarterectomy (nonbypass group). Patients with any previous diagnosis of ischemic or hemorrhagic stroke, moyamoya disease, cancer, or trauma were all excluded.RESULTSThe risk of subsequent ischemic stroke events decreased by 41% in the bypass group (adjusted hazard ratio [HR] 0.59, 95% CI 0.46–0.76, p < 0.001) compared with the nonbypass group. The risk of subsequent hemorrhagic stroke events increased in the bypass group (adjusted HR 2.47, 95% CI 1.67–3.64, p < 0.001) compared with the nonbypass group.CONCLUSIONSBypass surgery does play an important role in revascularization of the ischemic brain, while also increasing the risk of hemorrhage in the early postoperative period. This study highlights the fact that the high risk of bypass surgery obscures the true benefit of revascularization of the ischemic brain and also emphasizes the importance of developing improved surgical technique to treat these high-risk patients.
Variations in 30-day readmissions and length of stay among spine surgeons: a national study of elective spine surgery among US Medicare beneficiaries
Authors: Singh Siddhartha , Sparapani Rodney , Wang Marjorie C. 
Published: June 2018

OBJECTIVEPay-for-performance programs are targeting hospital readmissions. These programs have an underlying assumption that readmissions are due to provider practice patterns that can be modified by a reduction in reimbursement. However, there are limited data to support the role of providers in influencing readmissions. To study this, the authors examined variations in readmission rates by spine surgeon within 30 days among Medicare beneficiaries undergoing elective lumbar spine surgery for degenerative conditions.METHODSThe authors applied validated ICD-9-CM algorithms to 2003–2007 Medicare data to select beneficiaries undergoing elective inpatient lumbar spine surgery for degenerative conditions. Mixed models, adjusting for patient demographics, comorbidities, and surgery type, were used to estimate risk of 30-day readmission by the surgeon. Length of stay (LOS) was also studied using these same models.RESULTSA total of 39,884 beneficiaries were operated on by 3987 spine surgeons. The mean readmission rate was 7.2%. The mean LOS was 3.1 days. After adjusting for patient characteristics and surgery type, 1 surgeon had readmission rates significantly below the mean, and only 5 surgeons had readmission rates significantly above the mean. In contrast, for LOS, the patients of 288 surgeons (7.2%) had LOS significantly lower than the mean, and the patients of 397 surgeons (10.0%) had LOS significantly above the mean. These findings were robust to adjustments for surgeon characteristics and clustering by hospital. Similarly, hospital characteristics were not significantly associated with readmission rates, but LOS was associated with hospital for-profit status and size.CONCLUSIONSThe authors found almost no variations in readmission rates by surgeon. These findings suggest that surgeon practice patterns do not affect the risk of readmission. Likewise, no significant variation in readmission rates by hospital characteristics were found. Strategies to reduce readmissions would be better targeted at factors other than providers.
Traumatic brain injury in high versus low falls in young children and adolescents: a retrospective analysis
Authors: Bandte Angela , Püschel Klaus , Krajewski Kara 
Published: June 2018

OBJECTIVESo-called low falls are gaining interest in traumatology. To date, there are no studies on low versus high falls in the pediatric population. The aim of the current analysis was to characterize the symptoms, diagnostics, and injuries associated with high versus low falls and to examine the effect of fall height on injuries and outcome in the context of current guideline-based recommendations.METHODSAfter obtaining study approval from the local ethics committee, the authors reviewed the data for patients ages 5–17 years who had been consecutively treated at either hospital associated with the University Medical Center Hamburg in the period from January 2009 to August 2014 for diagnoses including traumatic brain injury (TBI). Retrospective analysis of the electronic patient charts was performed to obtain data on demographics; accident mechanism; initial neurological status with respect to consciousness, symptoms, and Glasgow Coma Scale score; radiological studies; diagnoses; length of stay; all intracranial procedures; and Glasgow Outcome Scale (GOS) score.RESULTSSixty-five fall-related TBIs among 380 patients were identified; 26 patients fell from a height of 3 m or more and 28 fell from a height under 3 m (height undocumented in 11 cases). Patients who fell from ≥ 3 m were 22 times more likely than those who fell from < 3 m to undergo spiral CT studies in the emergency room (p = 0.05). In addition, there was a 7.4 times greater chance of undergoing cranial CT (p = 0.02). There were significantly more noncerebral injuries requiring surgery in patients who fell from ≥ 3 m versus those who fell from < 3 m (p = 0.007). There was no difference in the frequency of neurosurgical procedures performed between low and high groups. Follow-up ranged from 0 to 92 months (mean 12.5 months, median 0 months). There was no significant difference in good (GOS score 4–5) and poor (GOS score 1–3) outcomes between high and low falls (p = 0.208).CONCLUSIONSLow falls can be associated with intracranial hemorrhages requiring ICU monitoring and/or surgery. The authors encourage intensive monitoring and CT scans based on clinical presentation, not on fall height.