bluuebunny/crossref_metadata_2025_split huggingface dataset:
O tamanho dos implantes atualmente disponíveis para a artroplastia total do quadril está adequado à nossa população?
Authors: Busato Thiago Sampaio , Barbosa Gabriella Maira Rodrigues , Velho Anderson Emanuel Kumandala , Matioski Filho Gladyston Roberto , Godoi Lucas Dias , Capriotti Juan R.V. 
Published: August 2019

Resumo
Objetivo Definir se as dimensões de alguns implantes de fabricação nacional e estrangeira utilizados nas cirurgias de artroplastia do quadril estão adequadas ao perfil antropométrico da população brasileira.
Métodos Estudo retrospectivo de pacientes submetidos a cirurgia primária de substituição artroplástica total do quadril. Foram excluídos deste estudo pacientes com alterações morfológicas femorais ou acetabulares que pudessem influenciar na escolha do tamanho dos implantes, tais como sequelas de displasia, trauma, entre outras. Foram incluídos neste estudo dois implantes de fabricação nacional e seis modelos importados. Todos os pacientes foram operados pela mesma equipe, por um dos quatro autores seniores ou sob sua supervisão direta, seguindo a mesma técnica cirúrgica. Os dados foram estatisticamente analisados em relação a gênero, idade, tipo de fixação e modelo dos implantes.
Resultados A análise estatística de 682 quadris submetidos a artroplastia total demonstrou que 2 modelos de hastes femorais cimentadas e 1 de haste não cimentada não estão perfeitamente adequados à morfologia femoral da população estudada, pois, na maioria dos casos, nestes 3 implantes, foi utilizado o menor tamanho disponível, resultando em uma curva não gaussiana. O diâmetro médio do acetábulo nativo foi de 54 mm nos homens e de 52 mm nas mulheres.
Conclusão Dos oito modelos estudados, cinco se mostraram adequados à população estudada. Outros três modelos disponíveis em nosso mercado (dois nacionais e um importado) parecem necessitar de um escalonamento mais adequado. Destacamos que são necessários estudos antropométricos do quadril da população brasileira para dar subsídios científicos ao desenho ideal dos implantes para o nosso mercado.
A Report of a Novel Pathogenic Variant in a Family with Buschke–Ollendorf Syndrome
Authors: Jain Angita , Selvam Pavalan , Atwal Herjot , Atwal Paldeep S. 
Published: August 2019

AbstractBuschke–Ollendorf Syndrome (BOS) is a benign autosomal dominant disorder caused by pathogenic mutations in LEMD3. Here, we describe a family diagnosed to have varied phenotypes associated with BOS. Single gene testing of LEMD3 detected a heterozygous frameshift pathogenic variant in both the affected family members. Besides the phenotypic description, this report highlights the need for a comprehensive evaluation in connective tissue disorders and the importance of genotype–phenotype correlation in BOS.
Transfusion-Associated Acute Lung Injury following Donor Granulocyte Transfusion in Two Pediatric Patients
Authors: Arslan Didar , Yildizdas Dincer , Horoz Ozden Ozgur , Aslan Nagehan , Leblebisatan Goksel 
Published: August 2019

AbstractTransfusion-associated acute lung injury (TRALI) is one of the complications seen due to transfusion. Hypoxemia and bilateral pulmonary infiltration in posteroanterior chest roentgenogram is seen in all cases during transfusion or within the first 6 hours; fever, hypotension, and pink frothy bleeding from endotracheal tube may also be seen. It can be seen following the administration of any blood product. The management strategies for TRALI include withholding the transfusion, positive pressure breathing support, and diuretics. There are few reported cases of TRALI occurring following donor granulocyte transfusion (DGT). In this article, we discuss two cases of TRALI following DGT transfusion.
Computed Tomography-Guided Transfissural Coil Localization of Lung Nodules
Authors: Xia Feng-Fei , Shi Yi-Bing , Wang Tao , Fu Yu-Fei 
Published: August 2019

Background The objective of this study was to evaluate the feasibility, safety, and clinical effectiveness of preoperative computed tomography (CT)-guided transfissural coil localization (TFCL) of subfissural lung nodules.
Methods Five patients with lung nodules who underwent CT-guided TFCL before video-assisted thoracoscopic surgery between November 2015 and December 2018 were included. Technical success rates of TFCL and wedge resection were assessed, as well complications and pathological results.
Results The technical success rate of TFCL was 100%. Two patients experienced parenchymal hemorrhage around the needle path, and two patients experienced asymptomatic pneumothorax after TFCL. The technical success rate of the wedge resection of lung nodules was also 100%. The pathological diagnoses of the five nodules were minimally invasive adenocarcinoma (n = 3), adenocarcinoma in situ (n = 1), and inflammatory nodule (n = 1).
Conclusion CT-guided TFCL is a safe and effective method for the preoperative localization of subfissural lung nodules.
Self-reactive and polyreactive B cells are generated and selected in the germinal center during γ-herpesvirus infection
Authors: Sakakibara Shuhei , Yasui Teruhito , Jinzai Hideyuki , O’Donnell Kristy , Tsai Chao-Yuan , Minamitani Takeharu , Takeda Kazuya , Belz Gabrielle T , Tarlinton David M , Kikutani Hitoshi 
Published: August 2019

Abstract
Immune responses against certain viruses are accompanied by auto-antibody production although the origin of these infection-associated auto-antibodies is unclear. Here, we report that murine γ-herpesvirus 68 (MHV68)-induced auto-antibodies are derived from polyreactive B cells in the germinal center (GC) through the activity of short-lived plasmablasts. The analysis of recombinant antibodies from MHV68-infected mice revealed that about 40% of IgG+ GC B cells were self-reactive, with about half of them being polyreactive. On the other hand, virion-reactive clones accounted for only a minor proportion of IgG+ GC B cells, half of which also reacted with self-antigens. The self-reactivity of most polyreactive clones was dependent on somatic hypermutation (SHM), but this was dispensable for the reactivity of virus mono-specific clones. Furthermore, both virus-mono-specific and polyreactive clones were selected to differentiate to B220lo CD138+ plasma cells (PCs). However, the representation of GC-derived polyreactive clones was reduced and that of virus-mono-specific clones was markedly increased in terminally differentiated PCs as compared to transient plasmablasts. Collectively, our findings demonstrate that, during acute MHV68 infection, self-reactive B cells are generated through SHM and selected for further differentiation to short-lived plasmablasts but not terminally differentiated PCs.
Rational Remedies: The Role of Opinion Clarity in the Inter-American Human Rights System
Authors: Staton Jeffrey K , Romero Alexia 
Published: August 2019

AbstractInternational courts have far-from-perfect records of compliance. States routinely delay the implementation of policy changes necessary to come into line with international obligations. Some judicial orders are simply ignored in their entirety. Yet judicial orders aimed at potentially recalcitrant states often vaguely express what is required and thus create conditions for delay and defiance. This article leverages a detailed public monitoring system for decisions of the Inter-American Court of Human Rights to evaluate a model of judicial opinion writing that connects the informational challenges associated with effectuating significant policy change to the language that judges adopt in their orders and, ultimately, to the reactions of states. Our results suggest that uncertainty about how precisely to bring about a policy change influences compliance by reducing the clarity of judicial orders. Flexibility in language permits judges to tradeoff maximal pressure for compliance for the ability to leverage local knowledge about how to bring a state in line with its international obligations. From this perspective, noncompliant outcomes are not necessarily a clear signal of weak judicial institutions, but, instead, they are a natural piece of the process by which judges manage difficult policy-making tasks.
Moxibustion-Induced Burns in a Burn Unit in Northeast China: An 8-Year Retrospective Analysis
Authors: Zhao Jing-Chun , Shi Kai , Xue Yan , Hong Lei , Yu Jia-Ao 
Published: August 2019

Abstract
The purpose of this paper was to analyze the characteristics of burns caused by moxibustion. A retrospective survey of the medical records of patients was performed on patients who visited our center from January 2009 to January 2017, treating for burns caused by moxibustion. Data were extracted and evaluated, including demographics, site and extent of burns, type and treatment duration of moxibustion, practitioners, and cost. A total of 82 consecutive patients treated for moxibustion-induced burns were included. The average patient age was 42.4 years, with the male to female ratio of 1.2:1. Burns caused by direct and indirect moxibustion were 7 and 75 cases, respectively. Averagely, moxibustion was performed 3.6 times a week for 3.7 weeks and lasts for 16.2 minutes each treatment. The average distance for indirect moxibustion was 3.4 cm (ranged from 2 to 5 cm) away from the acupoints. First-degree and superficial partial thickness burns, deep partial thickness burns, and full thickness burns were present in 16, 59, and 7 cases, respectively. Most of the burns were minor burns, with diameter less than 2 cm (69 cases). The most common sites were the lower extremities (46 cases), followed by abdomen (29 cases) and upper extremities (5 cases). The average cost for inpatients and outpatients was 5 164 and 2 192 RMB, respectively. Majority of moxibustion-induced burns are minor burns, and there is a high probability of the burn being deep if it occurs in the lower extremities.
Fireworks and Seafood Boils: The Epidemiology of Burns in Louisiana
Authors: Johnson Dylan M , White Levi J , Gilstrap Jameson , Short Tracee C 
Published: August 2019

Abstract
Epidemiological trends provide a means for targeting efforts in burn prevention. There have been but few regional-specific studies concerning burns in the southern United States. This study describes burn injury trends experienced by a single burn center in Louisiana. We also investigate the temporal relationships of several activities informally known for having a high risk for burn injury among local providers. Data were retrospectively extracted from the records of all patients treated for burn injuries at the regional burn center from 2012 to 2018 in both inpatient and outpatient settings. Demographical data and burn injury characteristics were noted. A total of 6,498 patients were included (1,593 inpatient, 4,905 outpatient). The most common burn etiologies were scald and flame, with flame being associated with more severe injuries. Overall incidence was disproportionally high in males and children less than 4 years of age. Total incidence was highest in Caucasians, though African Americans held the highest annual incidence rate specific to this population. The most common situation at the time of burn injury involved the consumption or preparation of food or beverages. Significant variation was observed in the rates of different injury situations throughout the year. Notably, burns related to seafood, heating, and firework activity occurred more often during crawfish season, colder months, and the months of January and July, respectively. In addition to establishing preliminary trends, these data may be useful in guiding the development of future evidence-based prevention efforts to target the most detrimental burn injuries in this population.
The Wake and the Work of Culture: Memorialization Practices in Post-Katrina Black Feminist Poetics
Authors: Pinto Samantha , Pereyra Jewel 
Published: August 2019

AbstractHurricane Katrina has come to represent a nexus of natural, infrastructural, and ethical failures that forced a moment and perhaps an era of public reckoning with the ongoing processes of black disenfranchisement from US state protections and rights. Poetry about Katrina both promises and is asked bear witness to this spectacular, violent show of force and to manage public and political appetites for recognition and remembrance through its ability to merge the material and the abstract in linguistic form. This cultural imperative stands as both opportunity and limit for black artists and poets, as they are expected to weigh in exclusively on the fates of black life, historical and present, and are frequently only given accolades and earn readership when they accede to this demand to represent the spectacle of Blackness in pain. In this article, we consider the Katrina-focused work of two prominent African American women poets, Claudia Rankine and Natasha Trethewey, arguing that they engage in innovative practices of poetic memorialization, performing black feminist “wake work” in their insistence on the long-standing, porous boundaries between black life and death, black expressive creation and precarity, and black material history and the present. Their work in Citizen: An American Lyric (2014) and in Beyond Katrina: A Meditation on the Mississippi Gulf Coast (2010) refashions the perverse poetic “opportunity” of Katrina as a moment to reframe black life and black cultural production both through and beyond the immediate temporality of disaster.
Superconductivity in chromium nitrides Pr3Cr10-xN11 with strong electron correlations
Authors: Wu Wei , Liu Kai , Li Yanjie , Yu Zhenhai , Wu Desheng , Shao Yuting , Na Shihang , Li Gang , Huang Ruizhen , Xiang Tao , Luo Jianlin 
Published: August 2019

Abstract
Exploration of superconductivity in Cr-based compounds has attracted considerable interest because only a few Cr-based superconductors (CrAs, A2Cr3As3 and ACr3As3 (A = K, Rb, Cs, Na)) have been discovered so far and they show an unconventional pairing mechanism. We report the discovery of bulk superconductivity at 5.25 K in chromium nitride in Pr3Cr10-xN11 with a cubic lattice structure. A relatively large upper critical field of Hc2(0) ∼ 12.6 T is determined, which is larger than the estimated Pauli-paramagnetic pair-breaking magnetic field. The material has a large electronic specific-heat coefficient of 170 mJ K−2 mol−1—about 10 times larger than that estimated by the electronic structure calculation, which suggests that correlations between 3d electrons are very strong in Pr3Cr10-xN11, and thus quantum fluctuations might be involved. Electronic structure calculations show that the density of states at the Fermi energy are contributed predominantly by Cr 3d electrons, implying that the superconductivity results mainly from the condensation of Cr 3d electrons. Pr3Cr10-xN11 represents a rare example of possible unconventional superconductivity emerging in a 3D system with strong electron correlations. Nevertheless, clarification of the specific pairing symmetry needs more investigation.
Fecal Transplant in Children With Clostridioides difficile Gives Sustained Reduction in Antimicrobial Resistance and Potential Pathogen Burden
Authors: Hourigan Suchitra K , Ahn Michelle , Gibson Keylie M , Pérez-Losada Marcos , Felix Grace , Weidner Melissa , Leibowitz Ian , Niederhuber John E , Sears Cynthia L , Crandall Keith A , Oliva-Hemker Maria 
Published: August 2019

AbstractBackgroundFecal microbiota transplantation (FMT) treats Clostridioides difficile infection (CDI). Little is known regarding the changes in antimicrobial resistance (AMR) genes and potential pathogen burden that occur in pediatric recipients of FMT. The aim of this study was to investigate changes in AMR genes, potential pathogens, species, and functional pathways with FMT in children.MethodsNine children with recurrent CDI underwent FMT. Stool was collected from donor and recipient pre-FMT and longitudinally post-FMT for up to 24 weeks. Shotgun metagenomic sequencing was performed. Reads were analyzed using PathoScope 2.0.ResultsAll children had resolution of CDI. AMR genes decreased post-FMT (P &lt; .001), with a sustained decrease in multidrug resistance genes (P &lt; .001). Tetracycline resistance genes increased post-FMT (P &lt; .001). Very low levels of potential pathogens were identified in donors and recipients, with an overall decrease post-FMT (P &lt; .001). Prevotella sp. 109 expanded in all recipients post-FMT, and no recipients had any clinical infection. Alpha diversity was lower in recipients vs donors pre-FMT (P &lt; .001), with an increase post-FMT (P ≤ .002) that was sustained. Beta diversity differed significantly in pre- vs post-FMT recipient samples (P &lt; .001). Bacterial species Faecalibacterium prausnitzii and Bacteroides ovatus showed higher abundance in donors than recipients (P = .008 and P = .040, respectively), with expansion post-FMT. Biosynthetic pathways predominated in the donor and increased in the recipient post-FMT.ConclusionsFMT for CDI in children decreases AMR genes and potential pathogens and changes microbiota composition and function. However, acquisition of certain AMR genes post-FMT combined with low levels of potential pathogens found in donors suggests that further study is warranted regarding screening donors using metagenomics sequencing before FMT.
Safety and Immunogenicity of Sabin Strain Inactivated Poliovirus Vaccine Compared With Salk Strain Inactivated Poliovirus Vaccine, in Different Sequential Schedules With Bivalent Oral Poliovirus Vaccine: Randomized Controlled Noninferiority Clinical Trials in China
Authors: Hu Yuemei , Xu Kangwei , Han Weixiao , Chu Kai , Jiang Deyu , Wang Jianfeng , Tian Xiaohui , Ying Zhifang , Zhang Ying , Li Changgui , Zhu Fengcai 
Published: August 2019

Abstract

Background
A new Sabin strain inactivated poliovirus vaccine (sIPV) proved to be immunogenic and safe in all IPV primary immunization in the previous study, with the corresponding profiles in sequential immunizations unclear.

Methods
Two clinical trials on the “IPV + 2 bivalent oral polio vaccine (2bOPV)” (Trial A) and “2IPV + bOPV” (Trial B) vaccination were conducted. Both clinical trials were randomized, controlled, double-blinded, noninferiority trials, and wild-strain IPV (wIPV) was adopted as the control vaccine. In each clinical trial, 240 healthy infants were enrolled and randomly assigned to receive sequential vaccinations containing sIPV or wIPV. Immunogenicity and safety were assessed using per-protocol and safety populations, respectively.

Results
For Trial A, the seroconversion rates in the experimental and control groups were 100% and 99.1%, respectively, against type 1; both 100.0% against type 3. For Trial B, the seroconversion rates in experimental and control groups were 99.2% and 100.0%, respectively, against type 1; both 100% against type 3. No serious adverse events related to vaccines were reported.

Conclusions
The new sIPV demonstrated an immunogenicity noninferior to that of the wIPV and a good safety profile in sequential vaccination with bOPV.

Clinical trial numbers
NCT:03822754; NCT:03822767.
Diagnosis and initial management in psoriatic arthritis: a qualitative study with patients
Authors: Dures Emma , Bowen Clive , Brooke Mel , Lord Jane , Tillett William , McHugh Neil , Hewlett Sarah 
Published: August 2019

Abstract

Objectives
PsA is an inflammatory condition that can cause pain, fatigue, swelling and joint stiffness. The consequences include impaired physical function, a high psychosocial burden, reduced quality of life and work disability. The presenting symptoms can be non-specific and varied, leading to delays in diagnosis or referral to specialist teams. The aim of this study was to explore patients' experiences of being diagnosed and the initial management of PsA.

Methods
The study used a qualitative design, with data collected in one-to-one, face-to-face semi-structured interviews.

Results
Fifteen newly diagnosed patients (<24 months) from three hospital sites in the southwest of England participated. Interviews were transcribed, anonymized and analysed using inductive thematic analysis. The following two main themes with sub-themes represent the data: symptom onset to specialist care: ‘it was the blind leading the blind’ (making sense of symptoms; mis-diagnosis and missed opportunities; and fast and easy access to expertise); and diagnosis as a turning point: ‘having somebody say you've got something wrong with you, I was euphoric’ (validation and reassurance; weighing up treatment options; taking on self-management; and acknowledging loss and change).

Conclusion
Participants were already dealing with functional limitations and were highly distressed and anxious by the time they received their diagnosis. Physical and mental outcomes could be improved by the implementation of existing psoriasis management guidelines and strategies for earlier referral from primary care to rheumatology and by the development of guidelines on educational, self-management and psychological support provision soon after diagnosis.
High rate of indeterminate results of the QuantiFERON-TB Gold in-tube test, third generation, in patients with systemic vasculitis
Authors: Rousset Stella , Treiner Emmanuel , Moulis Guillaume , Pugnet Grégory , Astudillo Léonardo , Paricaud Kim , Puissant-Lubrano Bénédicte , Arlet Philippe , Blancher Antoine , Sailler Laurent 
Published: August 2019

Abstract

Objectives
To describe the frequency of QuantiFERON-TB Gold in-tube test® (QFT-GIT) indeterminate results due to no response to phytohaemagglutinin A stimulation in the control tube in vasculitis patients prior to immunosuppressant therapy; and to compare it with other groups of patients.

Methods
This was a single-centre, retrospective study. Patients and controls were included between 1 January 2008 and 31 December 2015. We assessed the rate of indeterminate results of the QFT-GIT in 38 patients with systemic vasculitis prior to any corticosteroid or immunosuppressant therapy, compared with 40 non-vasculitis patients with biological inflammatory syndrome, and 310 non-immunosuppressed patients matched for gender and age.

Results
Indeterminate results due to no response to phytohaemagglutinin A were more frequent in vasculitis patients (21.1%) compared with non-vasculitis patients with biological inflammatory syndrome (7.5%) (Fisher's exact test: P = 0.11) and to anonymized controls (7%) (P = 0.009). Responses to phytohaemagglutinin A were significantly lower in vasculitis patients compared with other groups (Kruskal–Wallis test: P &lt; 0.0001) and compared with non-vasculitis patients with biological inflammatory syndrome (P = 0.0015). The multivariable analysis identified as independent predictors of an indeterminate result of the QFT-GIT: the presence of systemic vasculitis (odds ratio 9.64 [1.14–81.3], P = 0.037) and a high neutrophil-to-lymphocyte ratio (odds ratio 1.70 [1.21–2.37], P = 0.002). One patient with an indeterminate result of QFT-GIT developed active tuberculosis after one year of corticosteroid therapy for giant cell arteritis.

Conclusion
Our results question the reliability of QFT-GIT to rule out latent tuberculosis in vasculitis patients at diagnosis, prior to immunosuppressant therapy.