bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ligadura del conducto arterioso en recién nacidos prematuros: experiencia del Hospital Nacional de la Mujer
Authors: Delgado Montano Francisco Javier , Parada Lorenzana James 
Published: June 2019

Introducción. El ductus arterioso es una estructura que en la vida fetal se origina del sexto arco aórtico izquierdo embrionario y su función es primordial para la vida del feto. Posterior al nacimiento, su permeabilidad y persistencia se considera una cardiopatía y debe tratarse. Materiales y métodos. Se revisaron 18 expedientes médicos de pacientes con ductus arterioso de repercusión hemodinámica sometidos a cirugía. Todos los pacientes fueron abordados por la técnica de toracotomía lateral izquierda y se realizó doble ligadura al conducto. El tiempo postoperatorio y sus cuidados se cumplieron en la unidad de cuidados intensivos neonatales. Resultados. El total de pacientes operados fue de 18. El rango de pesos del grupo operado se encontraba entre 696 y los 2000 gramos. La edad gestacional se encontraba entre las 24 a 34 semanas. Se operaron 12 pacientes del sexo femenino y 6 masculinos. Se presentaron complicaciones postoperatorias en 5 casos. Tres pacientes tuvieron falla cardíaca que se trató de forma oportuna y dos casos terminaron con un ductus arterioso permeable residual luego de la ligadura. Fallecieron 3 pacientes sometidos a cirugía, pero la causa de muerte se debió a procesos infecciosos (un caso de neumonía nosocomial y dos por sepsis). Conclusiones. Valorando los riesgos versus los beneficios de la ligadura del ductus arterioso permeable, esta medida de tratamiento ha resultado ser una opción válida, ya que en El Salvador no se cuentan con medicamentos en presentación parenteral (indometacina-ibuprofeno) para el cierre farmacológico de esta cardiopatía.
Palabras clave: prematurez, ligadura, ductus arterioso, El Salvador.
The Music Box: Songs of Futility in a Time of Torture
Authors: Friedson Steven M. 
Published: June 2019

AbstractTwo musical moments on the edge: At a black site in Thailand, Abu Zubaydah, the first high-value detainee in the “Global War on Terror,” is placed inside a confinement box less than three feet square. All the while, music—from death metal to Barney the Purple Dinosaur’s “I Love You”—blasts unpredictably, unrelentingly. Not only in the box but day and night Zubaydah was subjected to a musical assault that was inescapable, nailing him to an existential hell with no future, no past. Ama, an elderly fishmonger, regularly gets possessed by the mother of a pantheon of deities from northern Ghana. At shrine celebrations, she is no longer herself but a dancing god being praised by drum and song. As long as the mother is there, Ama is away. One musical experience is the ontological inversion of the other. For the Brekete shrines of the Guinea Coast, musical experiences are energy producing, life affirming, a being-with-others through the sacrifice of the one possessed. In detention cells, whether in Thailand or in Guantánamo Bay, they are life diminishing, isolating, sacrificial, though not a sacrifice of the sacred kind. American torture and African trance, as delimited here, meet at the boundaries of musical experience and in so doing refract each other in a mirrored play, a ring dance of being-there and being-away. What follows is a talk of extremes, of musical experience at the margins, on the edge, limit experiences where selves are torn asunder and thrust into musical existences not of their own making.
Parental management of developmental coordination disorder: Validation of a French translation of the Parental Knowledge and Skills Questionnaire
Authors: Pratte Gabrielle , Schuster Tibor , Berbari Jade , Camden Chantal 
Published: June 2019

Background: Best practices in Developmental Coordination Disorder (DCD) recommend building parental capacities to enhance children’s functioning but few outcome measures are available to document the impact of such interventions. The Parent Knowledge and Skills Questionnaire (PKSQ) is a valid instrument currently only available in English evaluating parental perception of their ability to manage their child, understand DCD’s impact and use knowledge about DCD. The aim of the study was to translate the PKSQ in French and assess the factor structure consistency between the French and English versions.Methods: PKSQ was translated in French using a back-translation method. Parents of children with DCD were recruited in collaboration with the DCD association and rehabilitation centers. Parents completed the questionnaire online (n = 99). Confirmatory factor analysis was conducted based on the questionnaire response data and estimated item-domain correlations were compared with the English version.Results: All items of the original PKSQ were culturally appropriate in the Quebec French context and were thus included in the final version (n = 22). The French questionnaire version showed overall good consistency with the English version. The frequency of statistically inferior item-domain correlations was consistent with the expected rate of 5% under the no difference assumption (3/22, 95% confidence interval: 3% to 35%). Items showed moderate to large correlations with their underlying construct (estimated item-domain correlations between 0.45-0.91).Conclusions: Results suggest the French version of the PKSQ is consistent with the 3-factor structure of the English version, and may now be used to evaluate interventions based on DCD best practices.
Spotting the “small eyes”: using photo-ID methodology to study a wild population of smalleye stingrays (Megatrygon microps) in southern Mozambique
Authors: Boggio-Pasqua Atlantine , Flam Anna L. , Marshall Andrea D. 
Published: June 2019

Background
The smalleye stingray (Megatrygon microps) is a large and rare dasyatid ray, patchily distributed across the Indo-West Pacific. Free-swimming individuals have regularly been recorded in Southern Mozambican coastal waters utilizing different inshore environments. Distinctive features of the species include latitudinal rows of white spots on the dorsal surface of their pectoral disc.

Methods
This study aimed to determine if the natural spot patterns on M. microps are sufficiently unique and stable to use in photo-identification studies of wild populations. Research dive logs were combined with opportunistic photographs from local dive centers and recreational divers to create a photographic database from the Inhambane Province coastline.

Results
Seventy different individuals were identified over a 15-year period, all exhibiting uniquely identifiable patterns. Stingrays were easily identifiable over a period of six years with multiple re-sightings of the same individuals recorded. Analysis of encounters across the Inhambane coastline revealed that individual rays regularly use inshore reefs along a 350 km stretch of coastline. Fifteen stingrays were re-sighted during the study period, including one showing a 400 km return movement between Tofo Beach and the Bazaruto Archipelago, which is the longest distance traveled by a dasyatid ray on record. Several presumably pregnant females have also been recorded in the Bazaruto Archipelago National Park.
Non-traditional Route for Three Antifungal Drugs in Fungal Keratitis Treatment
Authors: Sedhom Christine R , Abdel-Rahman Mohamed S , Hussein Mohamed S 
Published: June 2019

Aims: This study aims to evaluate the efficacy of the intrastromal route of antifungal drugs in treatment of fungal keratitis.
Study Design: Prospective non-controlled (single arm) interventional clinical study Place and Duration of Study: Ophthalmology Department, Assiut University Hospital, between March 2016 to November 2017.
Methodology: Corneal scrapings for direct smears and cultures were done for eighteen eyes of 18 consecutive patients and intrastromal injections were given according to sensitivity results.
Results: After one month of follow up of the cases in this study, 33.3% of the cases had rapid complete cure and the rest had incomplete cure with resolution of ulcer sizes by 55.34% ±6.78 after one or more intrastromal injection of antifungal drugs.
Conclusion: Intrastromal injection of antifungal drugs in treatment of fungal keratitis shows promising results in advanced cases of fungal keratitis when combined with the topical route.
Content release of extracellular vesicles in a cell‐free extract
Authors: Bonsergent Emeline , Lavieu Gregory 
Published: June 2019

Extracellular vesicles (EVs) transfer molecules from donor to acceptor cells. The EV‐content delivery process within the acceptor cell is poorly characterized. We developed a new cell‐free assay to assess EV‐content release in vitro. We found that EV‐cytosolic cargoes are released from EVs when isolated vesicles are incubated with purified plasma membrane sheets at acidic pH, a characteristic of the endolysosomal environment. This process is protein dependent. Our results suggest that EV‐content delivery occurs within the endo/lysosomes of acceptor cells and is triggered by acidification. This process resembles virus content delivery and may require membrane fusion. The assay presented here will facilitate investigations into the core machinery and mechanisms underlying EV content delivery.
Ultrafast Laser Pulses Enable One‐Step Graphene Patterning on Woods and Leaves for Green Electronics
Authors: Le Truong‐Son Dinh , Park Sangbaek , An Jianing , Lee Pooi See , Kim Young‐Jin 
Published: June 2019

AbstractFast, simple, cost‐efficient, eco‐friendly, and design‐flexible patterning of high‐quality graphene from abundant natural resources is of immense interest for the mass production of next‐generation graphene‐based green electronics. Most electronic components have been manufactured by repetitive photolithography processes involving a large number of masks, photoresists, and toxic etchants; resulting in slow, complex, expensive, less‐flexible, and often corrosive electronics manufacturing processes to date. Here, a one‐step formation and patterning of highly conductive graphene on natural woods and leaves by programmable irradiation of ultrafast high‐photon‐energy laser pulses in ambient air is presented. Direct photoconversion of woods and leaves into graphene is realized at a low temperature by intense ultrafast light pulses with controlled fluences. Green graphene electronic components of electrical interconnects, flexible temperature sensors, and energy‐storing pseudocapacitors are fabricated from woods and leaves. This direct graphene synthesis is a breakthrough toward biocompatible, biodegradable, and eco‐friendlily manufactured green electronics for the sustainable earth.
Additive Manufacturing of 3D Structures Composed of Wood Materials
Authors: Kam Doron , Layani Michael , BarkaiMinerbi Sheer , Orbaum Donna , Abrahami BenHarush Shir , Shoseyov Oded , Magdassi Shlomo 
Published: June 2019

Abstract3D objects composed of 100% wood components are 3D printed utilizing wood flour microparticles dispersed in a matrix composed of cellulose nanocrystals and xyloglucan. In the printed object, a wood waste product is “glued” with extracted wood products, to be a substitute for pristine wood. 3D printing is used to maximize conversion of low value materials into final products that exhibit visual, textural, and physical properties of natural timber. Several 3D printing technologies are applied to achieve a wide range of densities, mechanical properties, colors, and morphologies as well as high thermal insulation. Furthermore, the 3D printing process enables predesigning of fiber layout in the printed wood, which enables control of shrinkage orientation.
Photoinduced Cascade Reaction of Tertiary Amines with Sulfonyl Azides: Synthesis of Amidine Derivatives
Authors: Ding Rui , Chen Hui , Xu Yan‐Li , Tang Hai‐Tao , Chen Yan‐Yan , Pan Ying‐Ming 
Published: June 2019

AbstractA metal‐free cascade reaction of tertiary amines with sulfonyl azides promoted by acridinium salts under blue light irradiation was developed and provided amidine derivatives in moderate to good yields. Enamine was generated from tertiary amine via single‐electron transfer promoted by acridinium salts, and the following [3+2] cyclization with sulfonyl azide and CH2N2 release afforded the desired products.magnified image
Cesium Fluoride and Copper‐Catalyzed One‐Pot Synthesis of Benzoxazoles via a Site‐Selective Amide C−N Bond Cleavage
Authors: Luo Zhongfeng , Wu Hongxiang , Li Yue , Chen Yuwen , Nie Jingyi , Lu Siqi , Zhu Yulin , Zeng Zhuo 
Published: June 2019

AbstractWe report herein a two‐step one‐pot strategy for the synthesis of benzoxazoles from amides by using cesium fluoride/copper as catalysts. This approach involves the in situ generation of acyl fluorides from the corresponding amides, and the acyl fluorides undergo transamidation and cyclization to give benzoxazoles in good yields. In this work, the amide C−N bonds are activated by CsF to form the acyl fluoride intermediates, which further react with o‐bromoanilines to efficiently yield benzoxazoles. Notably, this methodology demonstrates a broad substrate scope, as primary/secondary benzamides are well tolerated, and this process might facilitate the development of one‐pot transformations of amides.magnified image
One‐Pot Sequential Synthesis of Fused Isoquinolines via Intramolecular Cyclization/Annulation and their Photophysical Investigation
Authors: Rakshit Amitava , Sau Prasenjit , Ghosh Subhendu , Patel Bhisma K. 
Published: June 2019

AbstractOne of the cyano group of γ‐keto malononitrile gets hydrolyzed selectively to an amide in the presence of copper(II) acetate monohydrate. The in situ generated amide undergo an intramolecular dehydrative cyclization to a 1,2‐dihydropyridone intermediate. Further annulation of the 1,2‐dihydropyridone with an internal alkyne in the same pot produce a fused isoquinolone, 4‐oxo‐2,6,7‐triaryl‐4H‐pyrido[2,1‐a]isoquinoline‐3‐carbonitrile. This one‐pot process is associated with the formation of one C−C, two C−N, two C=C and a C=O bonds. The final synthesis is a four‐step process consisting of selective hydrolysis of a cyano group to an amide, dehydrative cyclization of the amide to a cyclic amide, aromatization of the cyclic amide (2‐oxo‐1,2,3,4‐tetrahydropyridine moiety) to a 2‐oxo‐1,2‐dihydropyridine and finally, the C−H/N−H annulation with an alkyne. Density functional theory calculation reveals that the highest occupied molecular orbital (HOMO) is localized at the central core extending to the nitrile group and a negligible contribution from the two phenyl rings of the diphenylacetylene. On the other hand, the lowest unoccupied molecular orbital (LUMO) is also localized at the identical central core and extended up to the other phenyl ring. The calculated ΔE(LUMO‐HOMO) is in the range of 2.88 to 3.45 eV and the compounds display emission in the green region (502–560) nm and absorption (λmax) in the range of (454–490) nm. Therefore, these molecules may find application in bio‐imaging, theranostics and various applications in material science.magnified image
Glibenclamide treatment in a Cantú syndrome patient with a pathogenic ABCC9 gain‐of‐function variant: Initial experience
Authors: Ma Alan , Gurnasinghani Sunita , Kirk Edwin P. , McClenaghan Conor , Singh Gautam K. , Grange Dorothy K. , Pandit Chetan , Zhu Yung , Roscioli Tony , Elakis George , Buckley Michael , Mehta Bhavesh , Roberts Philip , Mervis Jonathan , Biggin Andrew , Nichols Colin G. 
Published: June 2019

AbstractCantú syndrome (CS), characterized by hypertrichosis, distinctive facial features, and complex cardiovascular abnormalities, is caused by pathogenic variants in ABCC9 and KCNJ8 genes. These genes encode gain‐of‐function mutations in the regulatory (SUR2) and pore‐forming (Kir6.1) subunits of KATP channels, respectively, suggesting that channel‐blocking sulfonylureas could be a viable therapy. Here we report a neonate with CS, carrying a heterozygous ABCC9 variant (c.3347G>A, p.Arg1116His), born prematurely at 32 weeks gestation. Initial echocardiogram revealed a large patent ductus arteriosus (PDA), and high pulmonary pressures with enlarged right ventricle. He initially received surfactant and continuous positive airway pressure ventilation and was invasively ventilated for 4 weeks, until PDA ligation. After surgery, he still had ongoing bilevel positive airway pressure (BiPAP) requirement, but was subsequently weaned to nocturnal BiPAP. He was treated for pulmonary hypertension with Sildenafil, but failed to make further clinical improvement. A therapeutic glibenclamide trial was commenced in week 11 (initial dose of 0.05 mg–1 kg–1 day–1 in two divided doses). After 1 week of treatment, he began to tolerate time off BiPAP when awake, and edema improved. Glibenclamide was well tolerated, and the dose was slowly increased to 0.15 mg−1 kg−1day−1 over the next 12 weeks. Mild transient hypoglycemia was observed, but there was no cardiovascular dysfunction. Confirmation of therapeutic benefit will require studies of more CS patients but, based on this limited experience, consideration should be given to glibenclamide as CS therapy, although problems associated with prematurity, and complications of hypoglycemia, might limit outcome in critically ill neonates with CS.
Material encapsulation in poly(methyl methacrylate) shell: A review
Authors: Ahangaran Fatemeh , Navarchian Amir H. , Picchioni Francesco 
Published: June 2019

ABSTRACTMaterial encapsulation is a relatively new technique for coating a micro/nanosize particle or droplet with polymeric or inorganic shell. Encapsulation technology has many applications in various fields including drug delivery, cosmetic, agriculture, thermal energy storage, textile, and self‐healing polymers. Poly(methyl methacrylate) (PMMA) is widely used as shell material in encapsulation due to its high chemical stability, biocompatibility, nontoxicity, and good mechanical properties. The main approach for micro/nanoencapsulation of materials using PMMA as shell comprises emulsion‐based techniques such as emulsion polymerization and solvent evaporation from oil‐in‐water emulsion. In the present review, we first focus on the encapsulation techniques of liquid materials with PMMA shell by analyzing the effective processing parameters influencing the preparation of PMMA micro/nanocapsules. We then describe the morphology of PMMA capsules in emulsion systems according to thermodynamic relations. The techniques to investigation of mechanical properties of capsule shell and the release mechanisms of core material from PMMA capsules were also investigated. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48039.
Spatial generalized linear mixed models in small area estimation
Authors: Torabi Mahmoud 
Published: June 2019

AbstractIn survey sampling, policy decisions regarding the allocation of resources to sub‐groups of a population depend on reliable predictors of their underlying parameters. However, in some sub‐groups, called small areas due to small sample sizes relative to the population, the information needed for reliable estimation is typically not available. Consequently, data on a coarser scale are used to predict the characteristics of small areas. Mixed models are the primary tools in small area estimation (SAE) and also borrow information from alternative sources (e.g., previous surveys and administrative and census data sets). In many circumstances, small area predictors are associated with location. For instance, in the case of chronic disease or cancer, it is important for policy makers to understand spatial patterns of disease in order to determine small areas with high risk of disease and establish prevention strategies. The literature considering SAE with spatial random effects is sparse and mostly in the context of spatial linear mixed models. In this article, small area models are proposed for the class of spatial generalized linear mixed models to obtain small area predictors and corresponding second‐order unbiased mean squared prediction errors via Taylor expansion and a parametric bootstrap approach. The performance of the proposed approach is evaluated through simulation studies and application of the models to a real esophageal cancer data set from Minnesota, U.S.A. The Canadian Journal of Statistics 47: 426–437; 2019 © 2019 Statistical Society of Canada
How can HIV/STI testing services be more accessible and acceptable for gender and sexually diverse young people? A brief report exploring young people's perspectives in Queensland
Authors: Heard Emma , Oost Ellen , McDaid Lisa , Mutch Allyson , Dean Judith , Fitzgerald Lisa 
Published: June 2019

AbstractIssue addressedGender and sexually diverse young people (GSDYP) are an important target group for HIV/sexually transmitted infection (STI) prevention and there is an immediate need to explore ways to make testing interventions accessible and appropriate for this group.MethodsWe used a modified World Café workshop with 14 GSDYP in Brisbane Australia, to inform the development of a pilot community‐based testing intervention.ResultsThe workshop identified the key features of an ideal service, which would include multiple, accessible sites that offer holistic, affordable services and confidential care by respectful and knowledgeable providers. The service would allow young people to engage in decision‐making processes, have a culturally inclusive, comfortable and friendly atmosphere, and provide free sexual and reproductive health technologies.ConclusionWhen designing HIV/STI testing interventions for key groups, health promotion practitioners need to be cognisant of localised and nuanced expectations and ensure that services are tailored to the needs and experiences of the local population.So what?This study provides insights into the needs and expectations of HIV/STI testing interventions for GSDYP in Australia, a key at‐risk group whose perspectives are not adequately voiced in sexual health research and intervention design.SummaryThis study explores facilitators and current barriers to HIV/STI testing with a group of gender and sexually diverse young people in Brisbane, Australia. Outcomes provide insights into the needs and expectations of HIV/STI testing services for this group.
Concise Review: A Critical Evaluation of Criteria Used to Define Salivary Gland Stem Cells
Authors: Weng Pei-Lun , Aure Marit H. , Ovitt Catherine E. 
Published: June 2019

Abstract
In the effort to develop cell-based therapies to treat salivary gland dysfunction, many different populations of cells in the adult salivary glands have been proposed as stem cells. These cell populations vary, depending on the assay used, and are often nonoverlapping, leading to the conclusion that salivary glands harbor multiple stem cells. The goal of this review is to critically appraise the assays and properties used to identify stem cells in the adult salivary gland, and to consider the caveats of each. Re-evaluation of the defining criteria may help to reconcile the many potential stem cell populations described in the salivary gland, in order to increase comparability between studies and build consensus in the field. Stem Cells 2019;37:1144–1150