bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simple, low‐cost group‐counselling programme vs treatment as usual for patients with newly notified occupational hand eczema—Exploratory analyses of effects on knowledge, behaviour and personal resources of the randomized PREVEX clinical trial
Authors: Fisker Maja H. , Agner Tove , Sørensen Jennifer A. , Vejlstrup Søren G. , Lindschou Jane , Gluud Christian , Winkel Per , Bonde Jens P. , Ebbehøj Niels E. 
Published: May 2018

BackgroundSickness absence in hand eczema patients has been associated with stress rather than disease severity, indicating that personal aspects regarding hand eczema should be investigated further.ObjectivesTo examine whether patient education vs treatment as usual can influence behaviour and knowledge regarding skin protection and care, as well as personal resources, in patients with occupational hand eczema.MethodsPREVEX is an individually randomized clinical trial investigating the 1‐year effects of a simple, low‐cost group‐counselling programme vs treatment as usual for patients with notified occupational hand eczema. Exploratory outcomes were behaviour, knowledge, self‐efficacy, and self‐evaluated skin care ability.ResultsIn total, 1668 patients with notified occupational skin disease were invited to participate, of whom 769 were randomized and 756 were analysed: intervention group (n = 376) vs control group (n = 380). Behaviour was improved and the knowledge score increased in the intervention group as compared with the control group (respectively: estimate 0.08; 95%CI: 0.02‐0.19; P = .01; and estimate 0.49; 95%CI: 0.28‐0.70; P < .001). Self‐efficacy was lower in the intervention group as compared with the control group (estimate −0.78; 95%CI: −1.25 to −0.30; P = .001). No difference was found regarding skin care abilities.ConclusionsThe intervention had a positive influence on 1‐year behaviour and knowledge, but was insufficient to result in long‐term positive changes in personal resources regarding dealing with hand eczema.
BK viremia is not associated with adverse outcomes in the absence of BK nephropathy
Authors: Hertz‐Tang Amber L. , Astor Brad C. , Mandelbrot Didier A. , Mohamed Maha A. , Djamali Arjang , Parajuli Sandesh 
Published: May 2018

AbstractThere are limited data regarding the association of different levels of BK viremia and BK nephropathy (BKN), and graft outcomes. We studied the BK plasma PCR levels of all kidney transplant recipients (KTR) transplanted at our institution between 01/01/2006 and 06/30/2014. Patients were divided into groups based on their highest BK plasma PCR level within the first year following transplantation: undetectable, low (<1000 copies/mL), moderate (1000‐10 000 copies/mL), high (>10 000‐100 000 copies/mL), very high (>100 000 copies/mL), and those that had biopsy‐proven BKN. There were a total of 1146 KTR during the study period: 813 with undetectable BK levels and 333 with any detectable BK level (87 with low, 79 with moderate, 88 with high, 34 with very high level BK, and 45 that had BKN). Compared to KTR with an undetectable BK level, incidence of mortality, graft failure, rejections,and infections were not significantly different for those with low, moderate, high, or very high BK level. Patients with BKN had a higher rate of infection and higher rates of total graft failure or death‐censored graft failure compared to those with undetectable BK levels. BK viremia in the absence of BKN does not significantly increase the risk of rejection, infections, or graft failure compared to an undetectable BK level.
Conservative thickness layers in Mohs micrographic surgery
Authors: Tolkachjov Stanislav N. , Cappel Jonathan A. , Bryant Elizabeth A. , Harmon Christopher B. 
Published: May 2018

AbstractBackgroundMohs micrographic surgery (MMS) is used to treat cutaneous malignancies in locations to maximize tissue sparing. The authors’ aim is to demonstrate the utility of conservative thickness layers (CTL) in MMS and review patient and tumor characteristics and the potential anatomic locations where this technique may be most useful.MethodsWe performed a retrospective chart review of patients with tumors treated with CTL in MMS of 339 tumors, recording patient demographics, tumor characteristics, MMS stages for clearance, repairs, complications, and follow‐up.ResultsA total of 339 tumors were treated with CTL. The most common site was the leg (28.6%), with 77.4% of these being female. The next most common sites were nose (24.5%), scalp (13.9%), and back (11.5%). Most tumors were cleared with one layer (269), but some required two layers (42), three layers (11), and four layers (1). A total of 264 tumors were left to granulate, while 75 of the nasal tumors had immediate dermabrasion.ConclusionIn the properly selected patient and anatomic location, CTL taken as the first stage in MMS can be an effective and time‐saving technique, leaving wounds in optimal condition for granulation with a low complication rate. Tissue sparing may allow for more reconstructive options.
Rapid detection and toxicity assessment of citreoviridin using luminescent Vibrio qinghaiensis sp.‐Q67 in drinking water
Authors: Wu Shizheng , Zhang Xuhui , Yang Panpan , Li Liang , Tang Shuze 
Published: May 2018

SummaryCitreoviridin (CIT), one of the mycotoxins produced by Penicillium citreoviridin (PCV), is a common contaminant in a wide range of agricultural products and is detrimental to human and animal health. There is potential threat that terrorists can extract CIT from mouldy cereals, such as rice which forms the major source of starch intake in Asia–Pacific diets and corns which are readily available. The objective of this study was to develop a rapid method for detection of citreoviridin and evaluate its performance on luminescent bacterium Vibrio qinghaiensis sp.‐Q67 (Q67). A good correlation (R2 > 0.98) between concentrations of CIT and the relative luminosity unit of Q67 was obtained with a linear range from 0.0005 to 0.01 mg L−1. The precision expressed as relative standard deviation (RSD) was 3.2% for eleven replicate determinations of 0.005 mg L−1 CIT, and the recoveries of spiked samples were 88%–93%. The luminescence inhibition ratio of CIT increased from 0.0005 to 0.5 mg L−1, and the luminescence inhibition ratio remained stable at approximately 85% in the range of 0.5–10 mg L−1. The system detected low traces (≤0.0005 mg L−1) of CIT, and it has potential to be used as rapid detection method for mycotoxins. The effect of pure CIT on Q67 was time dependent and, it was the strongest (EC50 = 0.0066) at 20 min which indicated the high effect of CIT on Q67. Results obtained in this study suggest that Q67 is a promising method for rapid evaluation of the toxicity of CIT. Therefore, the luminescent bacteria assay can potentially be used as a system in monitoring sudden pollution in drinking water.
Asset Pricing with a Bank Risk Factor
Authors: PEREIRA JOÃO PEDRO , RUA ANTÓNIO 
Published: May 2018

AbstractThis paper studies how the state of the banking sector influences stock returns of nonfinancial firms. We consider a two‐factor pricing model, where the first factor is the traditional market excess return and the second factor is the change in the average distance to default of commercial banks. We find that this bank factor is priced in the cross section of U.S. nonfinancial firms. Controlling for market beta, the expected excess return for a stock in the top quintile of bank risk exposure is on average 2.83% higher than for a stock in the bottom quintile.
Measuring Inflation Expectations Uncertainty Using High‐Frequency Data
Authors: CHAN JOSHUA C.C. , SONG YONG 
Published: May 2018

AbstractInflation expectations play a key role in determining future economic outcomes. The associated uncertainty provides a direct gauge of how well‐anchored the inflation expectations are. We construct a model‐based measure of inflation expectations uncertainty by augmenting a standard unobserved components model of inflation with information from noisy and possibly biased measures of inflation expectations obtained from financial markets. This new model‐based measure of inflation expectations uncertainty is more accurately estimated and can provide valuable information for policymakers. Using U.S. data, we find significant changes in inflation expectations uncertainty during the Great Recession.
Moxibustion for Cephalic Version of Breech Presentation
Authors: Schlaeger Judith M. , Stoffel Cynthia L. , Bussell Jeanie L. , Cai Hui Yan , Takayama Miho , Yajima Hiroyoshi , Takakura Nobuari 
Published: May 2018

AbstractMoxibustion, a form of traditional Chinese medicine (TCM), is the burning of the herb moxa (Folium Artemisiae argyior mugwort) over acupuncture points. It is often used in China to facilitate cephalic version of breech presentation. This article reviews the history, philosophy, therapeutic use, possible mechanisms of action, and literature pertaining to its use for this indication. For moxibustion, moxa can be rolled into stick form, placed directly on the skin, or placed on an acupuncture needle and ignited to warm acupuncture points. Studies have demonstrated that moxibustion may promote cephalic version of breech presentation and may facilitate external cephalic version. However, there is currently a paucity of research on the effects of moxibustion on cephalic version of breech presentation, and thus there is a need for further studies. Areas needing more investigation include efficacy, safety, optimal technique, and best protocol for cephalic version of breech presentation.
Micropunch blepharopeeling versus blepharoplasty; what is the best procedure for upper eyelid rejuvenation?
Authors: Asilian Ali , Bafandeh Behzad , Shahmoradi Zabihollah , Faghihi Gita , Bostakian Anis , Mozafarpoor Samaneh , Hosseini Sayed Mohsen 
Published: May 2018

SummaryIntroductionPeriocular rejuvenation is the most common aesthetic plastic surgery. The aim of this study was to determine effects of micropunch blepharopeeling (MBP) approach vs blepharoplasty (BP) in periocular rejuvenation.Methods and materialsThis is a clinical trial study on 22 patients who underwent periorbital rejuvenation referred to University Skin Clinics. Patients were randomly divided into two groups of blepharoplasty or micropunch blepharopeeling. After procedure, all patients were followed in 2 weeks and 2 months and were asked about complications. Patients' satisfaction was scored based on 5‐grade scale. Physician satisfaction was assessed based on patients' photographs taken before and 2 months after surgery based on 4‐grade scale.ResultsThe mean age of group MBP was 48.45 ± 7.71 and group BP was 45.45 ± 7.20 (P‐value = .36) and Fitzpatrick skin type was not significantly different. Scar was significantly different between groups that 4 (36.4%) patients of BP complained from scars, while none of MBP had significant scar (P‐value = .04). Patients were statistically more satisfied with MBP in terms of symmetry, pain, and scar (P‐value = .048, .040, and<.001, respectively). Also, MBP was significantly more satisfying for physicians in terms of symmetry and scar (P‐value = .047 and <.001, respectively).ConclusionMicropunch blepharopeeling can be considered as an acceptable procedure of upper eyelid rejuvenation mentioned by patients and physicians. Micropunch blepharopeeling causes fewer scars, better symmetry, and less pain.
Improving posthospital medication management in a Danish municipality: A process evaluation
Authors: Kollerup Mette Geil , Curtis Tine , Laursen Birgitte Schantz 
Published: May 2018

Aims and objectivesTo evaluate an intervention developed to improve patient safety in posthospital medication management carried out by visiting nurses working in a municipality in Denmark. The intervention consisted of three elements: an initial interdisciplinary home visit by nurses, two subsequent scheduled visits and the use of an organising tool.BackgroundAs a consequence of specialised treatment plans and new treatment possibilities, patients with complex care needs can now be discharged from hospital more rapidly—and in greater numbers—than previously. Medication management is identified as the most challenging component of a discharge from the hospital to the home, in which discrepancies have been found in up to 94% of medication lists.DesignA process evaluation inspired by the UK Medical Research Council's guidance.MethodsThe process evaluation was conducted for three months in a visiting nurses’ department. Data consisted of visiting nurses’ self‐reports of performance of the intervention and group interviews (n = 4) with visiting nurses (n = 14). Self‐reports were analysed to evaluate implementation performance and elaborated with interview data to illuminate mechanisms of impact and contextual factors.ResultsThe implementation of the intervention highlighted the importance of the nurse–patient relationship, nursing assessment and logistics, and professional values in posthospital medication management. Complex care needs were a mediator in the high implementation rate, which involved 31 of the 38 patients in the target group.ConclusionFor patients with complex care needs, posthospital medication management may be improved by a reconsideration of the activity‐based funding of home health care, a recognition of the importance of organising work and a critical consideration of standard systems.Relevance to clinical practiceAn increase in the number of patients with complex care needs in home health care is an international issue that affects many healthcare systems. This study points at contextual challenges and possible methods for facilitating the future development of posthospital care for these patients.
Redefining perinatal experience: A philosophical exploration of a hypothetical case of gender diversity in labour and birth
Authors: Richardson Brianna , Price Sheri , Campbell‐Yeo Marsha 
Published: May 2018

Objective and aimsUsing a queer phenomenological approach, the objective of this philosophical analysis was to explore the transgender experience in highly gendered clinical areas, such as the birth unit, and make recommendations on how to provide perinatal care that is inclusive of gender diversity within these areas. This study aims to describe a hypothetical clinical experience to provide insight on the institutional barriers that currently exist and to provide nurses and midwives with pragmatic strategies to enhance gender‐diverse care in general and gendered clinical areas.BackgroundCurrently, general healthcare providers are not sufficiently educated on how to care for and meet the needs of people who identify as lesbian, gay, bisexual, trans, queer or questioning and other communities (LGBTQ+). This vulnerable population continually faces stigma, discrimination and marginalisation, which act as barriers to accessing healthcare services. Although transgender people often have difficulty accessing health care in general settings, they experience an even greater challenge within traditionally gendered clinical care areas.DesignQueer phenomenology was used to guide a critical philosophical analysis of hypothetical case reflecting a clinical scenario regarding a transgender man's experience in labour and birth.DiscussionHealthcare professionals often provide insufficient care to transgender persons, inadvertently leading to further marginalisation of this vulnerable population. Special consideration to provide gender‐diverse care throughout the perinatal period is needed. Structures and supports are essential to enhance the care from providers in attending to the unique needs of transgender individuals and reduce oppressive effects from heteronormative environments.Relevance to clinical practiceNurses and midwives are leading exemplars of providing person‐centred care and are capable of advocating for equitable care amongst all populations to influence systemic change. Strategies for implementing changes that address LGBTQ+ health needs and specific recommendations for providing gender‐diverse care in the perinatal settings are discussed.
Exploring the growth trajectory of cultural competence in Taiwanese paediatric nurses
Authors: Chen Chiu‐I , Huang Mei‐Chih 
Published: May 2018

AimTo explore the evolution of cultural competence in Taiwanese paediatric nurses.BackgroundBecause transnational marriage has become a social phenomenon in Taiwan, the proportion of newborns of new immigrant mothers accounts for 8%–10% of total births every year. As family‐centred care is the core value of paediatric nursing, it is necessary to teach caregivers how to take care of hospitalised children and perform related nursing care as well as to determine what difficulties nurses will encounter when they care for patients from diverse cultures and to find solutions for these problems. Unfortunately, few nursing programmes provide elective transcultural courses.DesignA phenomenological design was applied in the study.MethodA purposive sampling method was used. Nurses who had served in paediatric wards for over 1 year and who also had experience with taking care of the children of new immigrants were recruited as the informants. The data were collected through face‐to‐face in‐depth interviews and analysed using Moustakas’ method (1994). Rigour and trustworthiness was based on Yardley's evaluative criteria.ResultsThe researcher interviewed ten paediatric nurses. Their average age was 31.6 years. The mean seniority of their service in paediatric wards was 6.3 years. Four major themes were obtained from the data, including perceiving difficulties related to caring for patients from diverse cultures, self‐reflection on diverse cultures and the findings, finding approaches based on experiences with diverse cultures and new perceptions and identification with diverse cultures.ConclusionsIn this study, clinical nurses were interviewed who had not had cultural competency training during their nursing education. It is suggested that such courses be provided for nurses to improve their cultural competence.Relevance for clinical practiceAccordingly, educational strategies could be generated to improve nurses’ cultural competence related to clinical applications.
Acute and subacute antidiabetic studies of ENP-9, a new 1,5-diarylpyrazole derivative
Authors: Hernández-Vázquez Eduardo , Young-Peralta Sandra , Cerón-Romero Litzia , García-Jiménez Sara , Estrada-Soto Samuel 
Published: May 2018

Abstract

Objectives
To explore the antihyperglycaemic and antidiabetic effects and to determine the acute toxicity of 5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide (ENP-9).

Methods
The antihyperglycaemic effect of ENP-9 (50 mg/kg) was determined by oral glucose tolerance test (OGTT). Also, the acute (16, 50 and 160 mg/kg) and subacute (50 mg/kg/day for 10 days) antidiabetic effects of ENP-9 were determined. After subacute treatment, blood samples were analysed to determine glucose and lipid profiles. Also, an acute toxicity determination of ENP-9 was conducted followed the OECD recommendation. Molecular docking was performed using AutoDock 4.2.6 at human cannabinoid receptor 1 (PDB code 5TGZ).

Key findings
Acute Administration of ENP-9 showed significant antidiabetic effect and decreased the maximum OGTT peak, compared to the control group (P &lt; 0.05). Moreover, the 10 days treatment induced a decrease in plasma glucose levels, being significant at the end of the experiments (P &lt; 0.05); however, triacylglycerols and cholesterol were not modified. Finally, LD50 of ENP-9 was estimated to be greater than 2000 mg/kg. Molecular docking suggests that ENP-9 may act as rimonabant does.

Conclusions
ENP-9 showed significant antihyperglycaemic and antidiabetic properties and also was demonstrated to be safety in the studied doses, which might allow future studies for its potential development as antidiabetic agent.
A novel 4q25 microdeletion encompassing PITX2 associated with Rieger syndrome
Authors: Yang Yi , Wang Xin , Zhao Yuming , Qin Man 
Published: May 2018

AbstractObjectiveRieger syndrome (RS) is a genetic disorder characterized by abnormal development of the eyes, teeth, and umbilicus, and the paired‐like homeodomain 2 (PITX2) gene is often implicated in its pathogenesis. This study aimed to identify the underlying genetic defect in a Chinese patient with RS.Subjects and MethodsDNA samples were screened for PITX2 gene mutations and copy number variations (CNVs) using Sanger sequencing and genomic quantitative PCR analysis (qPCR). Chromosomal microarray analysis (CMA) was performed to fine‐map the CNVs.ResultsThe proband suffered from severe hypodontia and conical teeth in her permanent dentition. No PITX2 point mutations were found in this Chinese family, but a heterozygous deletion involving PITX2 was suspected and verified by the SNPs analysis and qPCR in the proband. An approximately 0.47 Mb (chr4: 111, 334, 313–111, 799, 327, GRCh37/hg19) deletion including PITX2 was finally determined by CMA.ConclusionsTo our knowledge, this is the first reported case of RS caused by a CNV of the PITX2 gene in a Chinese patient. CNV screening must be considered if point mutation screens yield negative results in these patients. The distribution of SNP genotypes among family members may also provide clues about gene deletion.
Efficacy and safety of brexpiprazole for the treatment of acute schizophrenia in Japan: A 6‐week, randomized, double‐blind, placebo‐controlled study
Authors: Ishigooka Jun , Iwashita Shuichi , Tadori Yoshihiro 
Published: May 2018

AimThis study aimed to evaluate the efficacy, safety, and tolerability of brexpiprazole compared to placebo in Japanese patients with acute schizophrenia (SCZ).MethodsWe conducted a 6‐week, multicenter, double‐blind, placebo‐controlled, phase 2/3 study in Japan. Patients with acute SCZ were randomized (1:1:1:1) to receive brexpiprazole 1 mg, 2 mg, 4 mg, or placebo once a day. The primary endpoint was the change from baseline to week 6 in Positive and Negative Syndrome Scale (PANSS) total scores.ResultsIn the 459 patients that were randomized, brexpiprazole 2 mg showed a significant improvement versus placebo (treatment difference: −7.32, P = 0.0124), although brexpiprazole 4 mg showed numerical improvements (treatment difference: −3.86, P = 0.1959), and brexpiprazole 1 mg showed only minimal change (treatment difference: −0.63, P = 0.8330). Treatment‐emergent adverse events with an incidence of ≥5% and ≥2 times the rate of placebo in the brexpiprazole groups were vomiting, elevated blood prolactin, diarrhea, nausea, and dental caries. Most treatment‐emergent adverse events were mild or moderate in severity. There were no clinically significant changes in electrocardiogram parameters, bodyweight, laboratory values, or vital signs in the brexpiprazole groups.ConclusionBrexpiprazole was efficacious and well tolerated in Japanese adult patients with acute SCZ.