bluuebunny/crossref_metadata_2025_split huggingface dataset:
Equecabtagene Autoleucel in Patients With Relapsed or Refractory Multiple Myeloma
Authors: Li Chunrui , Zhou Keshu , Hu Yongxian , Zou Dehui , Chen Lijuan , Chen Bing , Liu Jing , Zhang Xi , Ren Hanyun , Hu Kai , Liu Peng , Mi Jian-Qing , Li Zhenyu , Ding Kaiyang , Wang Di , Wang Wen , Cai Songbai , Li Jianyong , Song Yongping , Huang He , Qiu Lugui 
Published: November 2024

ImportanceEquecabtagene autoleucel (eque-cel), a fully human-derived B-cell maturation antigen-targeting chimeric antigen receptor (CAR) T-cell therapy, has exhibited potential for the treatment of relapsed or refractory multiple myeloma (RRMM), and further investigation in a larger cohort is necessary.ObjectiveTo evaluate whether eque-cel can benefit patients with RRMM and determine the overall response rate postinfusion.Design, Setting, and ParticipantsThe FUMANBA-1 trial was a single-arm, open-label, phase 1b/2 trial that evaluated eque-cel in adult patients with RRMM. Enrollment began in April 2020, and patients who received eque-cel will be monitored for a minimum of 15 years following the infusion. As of September 2022, patients with heavily pretreated RRMM who received at least 3 prior courses of therapy from 14 centers were enrolled. Data were analyzed from April 2020 to September 2022.InterventionsPatients received a single infusion of eque-cel at 1.0 × 106 CAR-positive T cells/kg after the lymphodepletion.Main Outcomes and MeasuresEfficacy was the primary objective, and safety, pharmacokinetics, and pharmacodynamics were secondary objectives.ResultsOf 103 patients who received an eque-cel infusion, 55 (53.4%) were male, and the median (range) age was 58 (39-70) years. A total of 101 patients were evaluable for efficacy. At a median (range) follow-up of 13.8 (0.4-27.2) months, the overall response rate was 96.0% (97 of 101), with 74.3% (75 of 103) achieving a complete response or better. Among the 12 patients who had prior CAR T-cell treatment, 75% (9 of 12) achieved a response. The median progression-free survival was not reached, with a 12-month progression-free survival rate of 78.8% (95% CI, 68.6-86.0). A total of 96 patients (95.0%) achieved minimal residual disease negativity at a sensitivity threshold of 10−5. Adverse events were favorable: 96 of 103 patients (93.2%) experienced cytokine release syndrome (grade 1 to 2 in 95 patients [92.3%]) and 2 (1.9%) experienced immune effector cell–associated neurotoxicity syndrome (grade 1 to 2). All cases of immune effector cell–associated neurotoxicity syndrome and 94 of 96 cases of cytokine release syndrome resolved with treatment. Additionally, only 20 patients (19.4%) developed antidrug antibodies. Cellular kinetic analysis confirmed CAR-positive T cells in all patients, with the longest duration at 735 days.Conclusions and RelevanceIn this trial, eque-cel led to early, deep, and durable responses in patients with heavily pretreated RRMM with a manageable safety profile. Patients with prior CAR T-cell therapy also benefitted from eque-cel.Trial RegistrationChinese Clinical Trial Registry Identifier: ChiCTR2000033946
Thermal Ablation for Papillary Thyroid Carcinoma
Authors: Yan Lin , Li Yingying , Li XinYang , Xiao Jing , Jing Haoyu , Yang Zhen , Li Miao , Song Qing , Wang Shurong , Che Ying , Luo Yukun 
Published: November 2024

ImportanceImage-guided thermal ablation has been administered for patients with T1N0M0 papillary thyroid carcinoma (PTC) who elect to not undergo surgery or receive active surveillance. Considering the indolent nature of PTC, long-term outcomes of ablation are needed.ObjectiveTo investigate l0-year outcomes of thermal ablation in treating T1N0M0 PTC.Design, Setting, and ParticipantsThis multicenter study was conducted at 4 university-affiliated hospitals in China and included 179 consecutive patients with T1N0M0 PTC (median [IQR] volume, 88.0 [163.2] mm3) who underwent thermal ablation between June 2010 and March 2014. Patients who were ineligible to undergo surgery or elected not to were included, and patients had PTC tumors that were smaller than 20 mm as confirmed by biopsy; no clinical or imaging evidence of extrathyroidal extension, lymph node metastasis (LNM), or distant metastasis; and no history of neck irradiation.Main Outcomes and MeasuresThe primary outcomes were disease progression (LNM, newly developed tumors, persistent tumors, and distant metastasis) and disease-free survival (DFS). Secondary outcomes were technical success, volume reduction rate, tumor disappearance, complications, and delayed surgery. DFS was calculated using a Kaplan-Meier analysis.ResultsAmong the 179 patients, the mean (SD) age was 45.8 (12.7) years, and 118 (65.9%) were female. During a mean (SD) follow-up period of 120.8 (10.8) months, disease progression was found in 11 of 179 patients (6.1%), including LNM in 4 patients (2.2%), newly developed tumors in 6 patients (3.3%), and persistent tumor in 1 patient (0.6%). The 10-year DFS was 93.9%. The technical success, median volume reduction rate, and tumor disappearance rate was 100%, 100%, and 97.2%, respectively. The magnitude of the disease progression (6.1% vs 7.1%; difference, 1.0%; 95% CI, −6.5% to 25.6%) and DFS (93.9% vs 92.9%; difference, 1.0%, 95% CI, −6.5% to 25.6%) between patients with T1a and T1b tumors was small. The difference in the rate of tumor disappearance between T1a and T1b tumors was large (99.4% vs 71.4%; difference, 28.0%; 95% CI, 10.9%-54.0%). One patient experienced transient voice hoarseness (0.6%). Because of anxiety, 1 patient underwent delayed surgery (0.6%).Conclusions and RelevanceThe results of this 10-year multicenter cohort study suggest that thermal ablation is an effective and safe alternative for patients with T1N0M0 PTC who do not undergo surgery or receive active surveillance. For safe and effective treatment, accurate radiologic evaluation, an understanding of ablation techniques, and experienced physicians are recommended.
Single‐Atomic Co‐N‐C Sites Anchored on Helical Carbonaceous Nanotubes for the Oxygen Reduction Reaction
Authors: Zhang Jieling , Mou Yonghong , Suo Weiran , Yang Shujiao , Shen Jian , Xu Hui , Zeng Zequan , Zhang Rong , Liang Zuozhong , Wang Yuan , Zheng Haoquan , Cao Jiahao , Cao Rui 
Published: November 2024

AbstractMetal‐coordinated N‐doped carbon (M‐N‐C) materials with highly curved structures have become a promising class of electrocatalysts for the oxygen reduction reaction (ORR). However, the stability of these electrocatalysts remains a problem due to the traditional post‐metal loading strategy. Herein, single‐atomic Co‐N‐C active sites anchored on helical carbonaceous nanotubes (HCNTs) are prepared (Co‐N‐C@HCNT) by pyrolyzing Co porphyrins and helical polypyrroles (PPys) mixtures at high‐temperature by one‐step method. Aberration‐corrected high‐angle annular dark‐field scanning transmission electron microscopy (HAADF‐STEM) and X‐ray absorption fine structure (XAFS) measurements confirm single‐atomic active sites and Co‐N4 coordination structures of Co‐N‐C@HCNT. The optimized Co‐N‐C@HCNT exhibits excellent catalytic ORR activity with a half‐wave potential (E1/2) of 0.86 V versus reversible hydrogen electrode (vs RHE) compared to Co‐N‐C@CNT without helical structures (E1/2 = 0.81 V vs RHE) measured in 0.1 m KOH. Co‐N‐C@HCNT also displays excellent stability with a slight current decrease (4%) after running for 10 h featuring Co‐N4 active sites tightly anchored on HCNTs due to electrostatic interactions between metal porphyrins and PPys. Theoretical calculations indicate that the curved structure can increase the charge and decrease d‐band center at Co active site, which enhances electrocatalytic activity. This work provides a simple but effective strategy to construct helical M‐N‐C materials.
Quantification of Emission Efficiency in Persistent Luminescent Materials
Authors: Castaing Victor , Romero Manuel , Rytz Daniel , Lozano Gabriel , Míguez Hernán 
Published: November 2024

AbstractAccurate quantification of efficiency enables rigorous comparison between different photoluminescent materials, providing an optimization path critical to the development of next‐generation light sources. Persistent luminescent materials exhibit delayed and long‐lasting luminescence due to the temporary storage of optical energy in engineered structural defects. Standard characterization methods do not provide a universal comparison of phosphor performance, hindering the evaluation of the efficiency of the various processes involved in afterglow. Here, a protocol is established to determine the quantum yield of persistent phosphors by considering the ratio of photons emitted in the afterglow and during charging to those absorbed. The method is first applied to transparent single crystals of the most common persistent phosphors, such as SrAl2O4:Eu2+,Dy3+ and Y3Al2Ga3O12:Ce3+,Cr3+. The versatility of the methodology is demonstrated by quantifying the quantum yield of a ZnGa2O4:Cr3+ thin film, a material widely used in in vivo imaging. The high efficiency of strontium aluminate is confirmed, and a strong dependence of the obtained values on the illumination conditions is revealed, highlighting a trade‐off between efficiency and brightness. The results contribute to the development of standardized protocols for analyzing afterglow mechanisms and assessing overall efficiency, facilitating rigorous comparison and optimization of persistent materials beyond trial‐and‐error approaches.
All‐Dielectric Fiber Meta‐Tip for Alignment‐Tolerant Bidirectional Interconnect Between Single‐Mode and Multi‐Mode Fibers
Authors: Li Jinke , Li Hongliang , Choi Duk‐Yong , Kim Jin Tae , Lee Woo‐Bin , Lee Sang‐Shin 
Published: November 2024

AbstractThe growing demand for enhanced data transmission and network scalability requires connecting multi‐mode fibers (MMFs) to single‐mode fibers (SMFs). However, conventional fiber‐optic connector systems face challenges such as one‐way transmission, alignment issues, and bulkiness. In this study, an all‐dielectric metasurface (MS)‐based fiber‐coupling system engineered to facilitate alignment‐tolerant bidirectional optical interconnect at a communication wavelength of 1550 nm is proposed and demonstrated. The system features meticulously aligned fiber meta‐tips incorporating an MS integrated onto SMF and MMF facets. The MS collimates the divergent beam emitted from the fiber facet and focuses the collimated beam propagating through free space, enabling bidirectional transmission of optical signals between the SMF and MMF. The achieved performance includes a coupling efficiency of −5.6 dB, optimal radial and axial tolerances of 40 and 600 µm, respectively, an extinction ratio of 13.8 dB, and a signal‐to‐noise ratio of 24.3 dB at 10.3 Gb s−1. The proposed fiber meta‐tips highlight the potential of lab‐on‐fiber technology for optical communication, trapping, and biological sensing.
Probing Optoelectronic Properties of Stable Vacancy‐Ordered Double Perovskites: Insights from Many‐Body Perturbation Theory
Authors: Adhikari Surajit , Johari Priya 
Published: November 2024

Abstract vacancy‐ordered double perovskites (VODPs) have captured substantial research interest in the scientific community as they offer environmentally friendly and stable alternatives to lead halide perovskites. In this study, the investigation is focused on (B = Ti, Se, Ru, Pd) VODPs as promising optoelectronic materials employing state‐of‐the‐art first‐principles‐based methodologies, specifically density functional theory combined with density functional perturbation theory (DFPT) and many‐body perturbation theory (within the framework of GW and BSE). These calculations reveal that all these materials possess a cubic lattice structure and are both dynamically and mechanically stable. Interestingly, they all exhibit indirect bandgaps, except displays a metallic character. The bandgap values for these compounds fall within the range of 3.63 to 5.14 eV. Additionally, the results of the BSE indicate that they exhibit exceptional absorption capabilities across the near‐UV to mid‐UV light region. Furthermore, studies on transport and excitonic properties suggest that they exhibit lower effective electron masses compared to holes, with exciton binding energies spanning between 0.16 and 0.98 eV. A significant observation is the prevalent hole‐phonon coupling compared to electron‐phonon coupling in these compounds. Overall, this study provides valuable insights to guide the design of vacancy‐ordered double perovskites as promising lead‐free candidates for future optoelectronic applications.
Prospective of Magnetron Sputtering for Interface Design in Rechargeable Lithium Batteries
Authors: Yao Yifan , Jiao Xingxing , Xu Xieyu , Xiong Shizhao , Song Zhongxiao , Liu Yangyang 
Published: November 2024

AbstractRechargeable lithium batteries (LBs) are considered the most promising electrochemical energy storage systems for utilizing renewable energies like solar and wind, ushering society into an electric era. However, the development of LBs faces challenges due to interfacial issues caused by side reactions between existing electrode and electrolyte materials. Magnetron sputtering (MS), a type of physical vapor deposition technology, offers solutions with its wide material selection, gentle deposition process, high uniformity of nano/micro‐scale thin films, and strong thin‐film adhesion. This review outlines the main operating principles of MS technology and explores its advanced applications in interfacial modification of various cathodes, anodes, separators, solid‐state electrolytes, and thin‐film LBs integrated with other microelectronic devices. Furthermore, the review discusses the potential of MS technology to accelerate scientific research and industrial progress toward higher‐performance LBs, advancing human society.
Evaluation of Ethanolic Extract of Red Seaweed (Gracilariopsis lemaneiformis) on Growth and Haematological Parameters of Nile Tilapia (Oreochromis niloticus)
Authors: Shahabuddin A. M. , Hannan Md. Abdul , Hossain Md. Foysul , Hemal Shahrear , Khanam Runi , Afroz Tahmina , Mustafa Ahmed 
Published: November 2024

ABSTRACTSeaweed is multicellular marine macroalgae that enhances the immunity of aquatic organisms. The study was designed to assess the ethanolic extract (EtOH) extracted from red seaweed (Gracilariopsis lemaneiformis) on Nile tilapia (Oreochromis niloticus) to evaluate growth, immunity and haematological parameters. The EtOH was applied with fish feed in four treatments such as T1‐control (0% EtOH), T2 (5% w/v EtOH), T3 (10% w/v EtOH) and T4 (15% w/v EtOH) each with three replicates. The initial average weight of the fish was 17.53 ± 2.1 g. Results showed that the growth increased gradually with the percentage of red seaweed extract, whereas the mean weight gain was found significantly higher in T4 (51.5 ± 4.2) than in the control. The specific growth rate (%) and survival rate (%) were found higher in T4 at the lowest FCR compared to other treatments (p < 0.05). The blood haemoglobin level of Nile tilapia was higher in T4 (11.5 g/dL) and lowest recorded in T1 (7.5 g/dL). However, the level of blood glucose interacted inversely with blood haemoglobin. The plasma protein level was also varied among the treatments (p > 0.05). The blood parameters, refractive index (RI) and spleen somatic index (SSI) were significantly different among the treatments. The RI of blood plasma and SSI were found to be better in T4 treatment. The research indicated that red seaweed extracts significantly enhanced the growth and boosted the immunity level of Nile tilapia.
Technology that CARES: Enhancing dementia care through everyday technologies
Authors: Kiselica Andrew M. , Hermann Greta E , Scullin Michael K. , Benge Jared F. 
Published: November 2024

Abstract“Everyday technologies” have long been suggested as digital tools to improve life for and enhance care of persons with Alzheimer's disease and related dementias (ADRD). Within this realm, there is a need to balance potential drawbacks of technologies with their ability to positively impact patient and care partner centered outcomes. To facilitate this goal, we endeavored to provide a common language and conceptual structure to understand digital technology use in ADRD care. Specifically, we describe the pathways by which researchers might develop and deploy technology, including via Cognitive offloading, Automation, Remote monitoring, Emotional/social support, and Symptom treatment (CARES). In addition, we highlight emerging issues in technology‐based care research and provide relevant caveats regarding application of digital technologies in the real world. This discussion provides a framework to organize science on the application of technologies to ADRD care in the future.Highlights
“Everyday technologies” have long been suggested as digital tools to improve life for and enhance care of persons with Alzheimer's disease and related dementias (ADRD).
However, the potential benefits of digital technologies must be balanced against their possible drawbacks.
We describe the pathways by which researchers might develop and deploy technology that CARES, including via Cognitive offloading, Automation, Remote monitoring, Emotional/social support, and Symptom treatment.
This discussion provides a framework to organize science on the application of digital technologies to ADRD care in the future.
Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology
Authors: Han Feng , Lee JiaQie , Chen Xi , Ziontz Jacob , Ward Tyler , Landau Susan M. , Baker Suzanne L. , Harrison Theresa M. , Jagust William J. ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: November 2024

AbstractINTRODUCTIONFactors responsible for the deposition of pathological tau in the brain are incompletely understood. This study links macroscale tau deposition in the human brain to cerebrospinal fluid (CSF) flow dynamics using resting‐state functional magnetic resonance imaging (rsfMRI).METHODSLow‐frequency (< 0.1 Hz) resting‐state global brain activity is coupled with CSF flow and potentially reflects CSF dynamics‐related clearance. We examined the correlation between rsfMRI measures of CSF inflow and global activity (gBOLD–CSF coupling) as a predictor, interacting with amyloid beta (Aβ), of tau and cortical thickness (dependent variables) across Alzheimer's Disease Neuroimaging Initiative (ADNI) participants from cognitively unimpaired through mild cognitive impairment (MCI) and Alzheimer's disease (AD).RESULTSTau deposition in Aβ+ participants, accompanied by cortical thinning and cognitive decline, is associated with decreased gBOLD–CSF coupling. Tau mediates the relationship between coupling and thickness.DISCUSSIONFindings suggest that resting‐state global brain activity and CSF movements comodulate Alzheimer's tau deposition, presumably related to CSF clearance.Highlights
A non‐invasive functional magnetic resonance imaging (fMRI) assessment of a CSF clearance‐related process is carried out.
Global brain activity is coupled with CSF inflow in human fMRI during resting state.
Global fMRI–CSF coupling is correlated with tau in Alzheimer's disease (AD).
This coupling measure is also associated with cortical thickness, mediated by tau.
Scalable Atomic‐Layer Tailoring of Abundant Oxide Supports Unlocks Superior Interfaces for Low‐Metal‐Loading Dehydrogenation
Authors: Kwak Yeonsu , Lee Yu‐Jin , Moon Seongeun , Lee Kimoon , Ramadhani Safira , On Eui‐Rim , Ahn Chang‐il , Hwang Son‐Jong , Sohn Hyuntae , Jeong Hyangsoo , Nam Suk Woo , Yoon Chang Won , Kim Yongmin 
Published: November 2024

AbstractLiquid organic hydrogen carriers (LOHCs) offer a promising solution for global hydrogen infrastructure, but their practical application faces two key challenges: sluggish dehydrogenation processes and the reliance on catalysts with high noble metal loadings. This study presents a scalable approach to reduce noble metal usage while maintaining high catalytic activity. We synthesized an ultralow Pt content (0.1 wt %) catalyst using γ‐Al2O3‐based pellet support with atomic layer deposition (ALD) of TiO2. Advanced characterization techniques reveal that the thin ALD‐TiO2 shell provides a heterogeneous interface, confining electronically rich Pt‐nanoparticle ensembles. The catalyst outperforms both equivalent Pt‐content catalysts and a commercial 0.5 wt % Pt/γ‐Al2O3 catalyst in homocyclic LOHC dehydrogenation. This study provides insights into the beneficial role of ALD‐engineered interfaces for catalytic supports and offers an efficient approach for scalable production of low‐noble‐metal‐content catalysts, with implications for various catalytic processes.
Electrical conductivity enhancement of chopped carbon fiber‐reinforced epoxy composite bipolar plate for proton exchange membrane fuel cells
Authors: Hanapi Iesti Hajar , Kamarudin Siti Kartom , Zainoodin Azran Mohd , Masdar Mohd Shahbudin , Kamarudin Siti Radiah Mohd , Radzuan Nabilah Afiqah Mohd , Beygisangchin Mahnoush , Zakaria Zulfirdaus 
Published: November 2024

AbstractThis study investigated the development of chopped carbon fiber (CCF)‐reinforced epoxy (EP)/graphite (G) composite bipolar plates (BPs) using a one‐step compression molding process. The primary objective was to fabricate CCF‐reinforced EP/G BPs to enhance their electrical conductivity performance by evaluating the electrical conductivity and compactness of the plate among expanded graphite (EG), carbon black (CB) Vulcan, a combination of EG and CB Vulcan, and CB Ensaco. The results indicated that the EG exhibited the highest electrical conductivity of 9.3 S cm−1 and compactness due to the low surface area. Consequently, CCF‐reinforced EP/G/EG was selected for further optimization using response surface methodology (RSM) to analyze the parameters of EG composition, CCF composition, and temperature for optimizing electrical conductivity and porosity. The optimum conductivity and porosity of the CCF‐reinforced EP/G/EG reached 22.7 S cm−1 and 9.84% with EG composition, CCF composition, and temperature of 7.56 wt.%, 6.63 wt.%, and 186°C, respectively. After optimization, EP/G/EG was connected to a circuit to light up a bulb. It showed a substantial improvement in illumination compared with the samples before optimization. Therefore, the use of CCF‐reinforced EP/G/EG with one‐step compression molding has proven highly successful for converting energy in renewable energy applications, showcasing exceptional performance.
Music therapy improves engagement and initiation for autistic children with mild intellectual disabilities: A randomized controlled study
Authors: Yum Yen Na , Poon Kean , Lau Way Kwok‐Wai , Ho Fuk Chuen , Sin Kuen Fung , Chung King Man , Lee Ho Yan , Liang Di Chao 
Published: November 2024

AbstractThis study aimed to evaluate the effectiveness of music therapy (MT) for children with co‐occurring autism spectrum disorder (ASD) and intellectual disabilities (ID) and explore whether pre‐intervention quantitative electroencephalogram (qEEG) responses can predict outcomes. A randomized controlled trial was conducted with 33 children receiving MT and 34 receiving an active control therapy. Participants received either MT or a non‐musical social skills intervention for 45 min weekly over 12 weeks. Primary outcomes were measured using the Childhood Autism Rating Scale (CARS‐2), along with the parent‐rated Social Responsiveness Scale (SRS‐2) and video coding of social behaviors. Both conditions significantly improved in CARS‐2 scores at 2 weeks and 4 months post‐intervention, with no differences between MT and control conditions. No changes were found in SRS‐2 scores. While both conditions showed reduced disengagement after intervention, only the MT condition showed increased engagement and initiation. Strong qEEG responses to social scenes and music predicted increased initiation, indicating its potential to help tailor interventions. These results support incorporating MT into standard services and further research on qEEG predictors.