bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhein reverses doxorubicin resistance in SMMC‐7721 liver cancer cells by inhibiting energy metabolism and inducing mitochondrial permeability transition pore opening
Authors: Wu Li , Cao Kexin , Ni Zihui , Wang Shaodong , Li Weidong , Liu Xiao , Chen Zhipeng 
Published: November 2018

AbstractRhein, a monomeric anthraquinone obtained from the plant herb species Polygonum multiflorum and P. cuspidatum, has been proposed to have anticancer activity. This activity has been suggested to be associated with mitochondrial injury due to the induction of mitochondrial permeability transition pore (mPTP) opening. In this study, the effects of 5–80 μM rhein on cell viability, half‐maximal inhibitory concentration (IC50 value), resistance index, and apoptosis were assessed in the liver cancer cell lines SMMC‐7721 and SMMC‐7721/DOX (doxorubicin‐resistant cells). Rhein (10–80 μM) significantly reduced the viability of both cell lines; 20 μM rhein significantly increased sensitivity to DOX and increased apoptosis in SMMC‐7721 cells, but reversed resistance to DOX by 7.24‐fold in SMMC‐7721/DOX cells. Treatment with rhein increased accumulation of DOX in SMMC‐7721/DOX cells, inhibited mitochondrial energy metabolism, decreased cellular ATP, and ADP levels, and altered the ratio of ATP to ADP. These effects may result from the binding of rhein with voltage‐dependent ion channels (VDACs), adenine nucleotide translocase (ANT), and cyclophilin D, affecting their function and leading to the inhibition of ATP transport by VDACs and ANT. ATP synthesis was greatly reduced and mitochondrial inner membrane potential decreased. Together, these results indicate that rhein could reverse drug resistance in SMMC‐7721/DOX cells by inhibiting energy metabolism and inducing mPTP opening. © 2018 BioFactors, 45(1):85–96, 2019
Microsomal pre‐receptor cortisol production is inhibited by resveratrol and epigallocatechin gallate through different mechanisms
Authors: Szelényi Péter , Somogyi Anna , Sarnyai Farkas , Zámbó Veronika , Simon‐Szabó Laura , Kereszturi Éva , Csala Miklós 
Published: November 2018

AbstractLocal activation of cortisol in hormone target tissues is a major determinant of glucocorticoid effect. Disorders in this peripheral cortisol metabolism play an important role in the development of metabolic diseases, such as obesity or type 2 diabetes mellitus. Hence, dietary factors influencing the activity of the involved enzymes can have major impacts on the risk of the above diseases. Resveratrol and epigallocatechin gallate (EGCG), two natural polyphenols found in several nutriments and in green tea, respectively, are well‐known for their antiobesity and antidiabetic activities. EGCG has been shown to interfere with microsomal cortisol production through decreasing the luminal NADPH:NADP+ ratio. The aim of this study was to clarify if resveratrol also induces such a redox shift or causes any direct enzyme inhibition that influences local cortisol production. Cortisone–cortisol conversions and changes in NADPH levels were monitored in rat liver microsomal vesicles. Cortisol production was inhibited by resveratrol in a concentration dependent manner while the intrinsic reducing and oxidizing capacity as well as the NADPH level inside the ER‐derived vesicles remained unaffected. Activity measurements performed in permeabilized microsomes confirmed that resveratrol, unlike EGCG, inhibits 11β‐hydroxysteroid dehydrogenase type 1 directly. Long‐term moderation of pre‐receptor cortisol production likely contributes to the beneficial health effects of both polyphenols. © 2018 BioFactors, 45(2):236–243, 2019
The effectiveness of university counselling for students with academic issues
Authors: McKenzie Karen , Murray Kara R. , Murray Aja L. , Richelieu Marc 
Published: November 2018

AbstractBackgroundThe demands of academic life are considered to be increasingly stressful for students in higher education, but there is limited research about the extent to which those attending student counselling services experience difficulties relating to academic issues and how effective counselling is for them.AimThe study aimed to evaluate the reliable and clinically significant change for students with self‐reported academic issues. Reliable change occurs when a change in the outcome being measured is not attributable to error, while clinically significant change occurs when a person moves from a clinical population to a healthy population after an intervention, in this case counselling.MethodologyPre‐existing data from 129 university students who had attended a student counselling service were analysed to determine levels of reliable change and clinically significant change. These data related to psychological status before and after counselling based on CORE‐OM total scores; self‐report of the impact of counselling on academic issues; and demographic variables.FindingsIn total, 117 (92%) of students reported experiencing academic issues to some extent. Counselling was found to result in reliable change for 67% and clinically significant change for 40% of those students reporting academic issues.ImplicationsThe results of the study suggest that, even where academic reasons are not the primary cause of referral to student counselling services, a significant number of students will also experience difficulties in these areas. Counselling was, however, shown to result in reliable and clinically significant change in a high percentage of those experiencing these additional difficulties.
A pH‐Responsive Glycyrrhetinic‐Acid‐Modified Small‐Molecule Conjugate for NIR Imaging of Hepatocellular Carcinoma (HCC)
Authors: Singh Hardev , Lim Ja‐Yun , Sharma Amit , Yoon Dae Wui , Kim Ji Hyeon , Yang Zhigang , Qu Junle , Kim Jinkwan , Lee Seung Gwan , Kim Jong Seung 
Published: November 2018

AbstractWe report a glycyrrhetinic‐acid (GA)‐decorated small‐molecule conjugate for pH‐triggered near‐infrared (NIR) fluorescence imaging of hepatocellular carcinoma (HCC). Our in vitro studies demonstrated that the conjugate, referred to as NIR‐GA, was efficiently taken up by liver cancer cell lines such as HepG2 and Huh7 through an endocytic pathway mediated by GA receptors. As suggested by co‐localization studies, NIR‐GA mainly localized in the lysosome, where the acidic pH results in the activation of the fluorescent dye through H+‐triggered spirolactam ring opening to give strong fluorescence in the NIR region.
Intravenous immunoglobulin for acute hemorrhagic leukoencephalitis refractory to plasmapheresis
Authors: Panchal Apurva , Perez‐Marques Francesca 
Published: November 2018

Key Clinical MessageIntravenous immunoglobulin therapy should be considered in pediatric acute hemorrhagic leukoencephalitis that is refractory to steroid and plasmapheresis.
Catalytic Upgrading of Biomass Model Compounds: Novel Approaches and Lessons Learnt from Traditional Hydrodeoxygenation – a Review
Authors: Jin Wei , Pastor‐Pérez Laura , Shen DeKui , Sepúlveda‐Escribano Antonio , Gu Sai , Ramirez Reina Tomas 
Published: November 2018

AbstractCatalytic hydrodeoxygenation (HDO) is a fundamental process for bio‐resources upgrading to produce transportation fuels or added value chemicals. The bottleneck of this technology to be implemented at commercial scale is its dependence on high pressure hydrogen, an expensive resource which utilization also poses safety concerns. In this scenario, the development of hydrogen‐free alternatives to facilitate oxygen removal in biomass derived compounds is a major challenge for catalysis science but at the same time it could revolutionize biomass processing technologies. In this review we have analysed several novel approaches, including catalytic transfer hydrogenation (CTH), combined reforming and hydrodeoxygenation, metal hydrolysis and subsequent hydrodeoxygenation along with non‐thermal plasma (NTP) to avoid the supply of external H2. The knowledge accumulated from traditional HDO sets the grounds for catalysts and processes development among the hydrogen alternatives. In this sense, mechanistic aspects for HDO and the proposed alternatives are carefully analysed in this work. Biomass model compounds are selected aiming to provide an in‐depth description of the different processes and stablish solid correlations catalysts composition‐catalytic performance which can be further extrapolated to more complex biomass feedstocks. Moreover, the current challenges and research trends of novel hydrodeoxygenation strategies are also presented aiming to spark inspiration among the broad community of scientists working towards a low carbon society where bio‐resources will play a major role.
On the Formation of Palladium (II) Iodide Nanoparticles: An In Situ SAXS/XAS Study and Catalytic Evaluation on an Aryl Alkenylation Reaction in Water Medium
Authors: Latocheski Eloah , Marques Marcelo V. , Albuquerque Brunno L. , Schuh Thalia J. , Signori Aline M. , Oliveira Daniela C. , Pal Taransankar , Domingos Josiel B. 
Published: November 2018

AbstractThe synthesis of small spherical palladium(II) iodide nanoparticles is reported for the first time. The formation of the particles by ligand exchange, in the presence of poly(vinyl pyrrolidone) in aqueous medium at room temperature, was investigated by in situ time‐resolved synchrotron‐based SAXS and XANES/EXAFS analysis. These new nanomaterials exhibit a double catalytic role in an aryl alkenylation chemical reaction, working without a base or ligand, in aqueous milieu. There is strong experimental evidence to suggest that the mechanism follows a single‐electron transfer (SET) pathway with the participation of iodide as a radical promoter and the palladium atoms as activator of the alkene moiety. This new protocol could evolve into a broadly applicable radical reaction for the functionalization of alkenes.
Intermediates of N‐Heterocyclic Carbene (NHC) Dimerization Probed in the Gas Phase by Ion Mobility Mass Spectrometry: C−H⋅⋅⋅:C Hydrogen Bonding Versus Covalent Dimer Formation
Authors: Paul Mathias , Detmar Eric , Schlangen Maria , Breugst Martin , Neudörfl Jörg‐Martin , Schwarz Helmut , Berkessel Albrecht , Schäfer Mathias 
Published: November 2018

AbstractN‐Heterocyclic carbenes (NHCs, :C) can interact with azolium salts (C−H+) by either forming a hydrogen‐bonded aggregate (CHC+) or a covalent C−C bond (CCH+). In this study, the intramolecular NHC–azolium salt interactions of aromatic imidazolin‐2‐ylidenes and saturated imidazolidin‐2‐ylidenes have been investigated in the gas phase by traveling wave ion mobility mass spectrometry (TW IMS) and DFT calculations. The TW IMS experiments provided evidence for the formation of these important intermediates in the gas phase, and they identified the predominant aggregation mode (hydrogen bond vs. covalent C−C) as a function of the nature of the interacting carbene–azolium pairs.
Transition‐Metal Acetate‐Promoted Intramolecular Nitrene Insertion to Vinylogous Carbonates for Divergent Synthesis of Azirinobenzoxazoles and Benzoxazines
Authors: Gharpure Santosh J. , Naveen Sudi , Samala Ganesh , Vishwakarma Dharmendra S. 
Published: November 2018

AbstractSynthesis and isolation of highly unstable azirinobenzoxazole and benzoxazines in a chemodivergent fashion from aryl azido vinylogous carbonates by simple change in transition metal acetate is described. Thermal or rhodium(II) acetate‐mediated decomposition of these azides gave dihydroazirino benzoxazole. Their nickel(II) acetate‐promoted reaction gave 4‐dihydro‐2H‐benzoxazines, whereas copper(II) acetate led to the corresponding oxidized imine derivatives. Benzaoxazine derivative could be kinetically resolved using a proline‐catalyzed Mannich reaction. The benzoxazines were rapidly elaborated to angularly fused tetracyclic systems and coumarin‐fused derivatives in a “one pot” fashion.
A robust computational method based on the thermodynamic approach for determining monomer partitioning in emulsion polymerization systems
Authors: Safinejad Ali , Pourmahdian Saeed , Hadavand Behzad Shirkavand 
Published: November 2018

AbstractA robust computational framework based on the thermodynamic approach for determining monomer partitioning in monodisperse/polydisperse multi‐component emulsion systems was introduced. The numerical methods were applied to determine monomer partitioning in three monodisperse and one hypothetical polydisperse multi‐monomer emulsion systems. Larger particle size promotes the swelling ability of particles and increases the monomers content ratio for monomer with lower solubility in particle phase. For polydisperse systems, there is a strong particle size dependency of polymer volume fraction and the volumetric ratio of the monomers in particles, even for large particles and/or under partial swelling condition. In monodisperse systems, the particle size independency of monomers' volumetric ratio is only valid for large enough particles and/or partial swelling conditions. The results show that the prediction of the thermodynamic model can be brought close to reasonable results only with values of interfacial tensions, which are several times higher than the experimentally measured data.
Melt‐synthesis of LiFePO4 over a metallic bath
Authors: Villazon Hernando , Sauriol Pierre , Rousselot Steeve , Talebi‐Esfandarani Majid , Bibienne Thomas , Gauthier Michel , Liang Guoxian , Dollé Mickaël , Chartrand Patrice 
Published: November 2018

AbstractCompared with large‐scale processes, the LiFePO4 (LFP) melt‐synthesis is a low‐cost method with short dwell times and rapid reaction rates. However, secondary phases and impurities remaining in the olivine structure lower the cathode's electrochemical properties. Starting from a low‐cost Fe3+ precursor, we evaluated tin and silver charged metallic baths to purify the melt‐synthesis of LiFePO4 at laboratory scale. In the tin bath exploration, an x‐ray diffraction (XRD) confirmed the olivine structure and a temperature‐dependent generation of Li3PO4 and Li4P2O7. An SEM image analysis identified tin‐rich phases (SnxPyOz) segregated from the LFP structure and FexP phases on the internal walls of the crucible. A multi‐element analysis (ICP‐AES) detected more than 0.03 g of Sn/g of LFP. The tin bath prepared samples delivered up to156 mAh/g of LFP in a carbon‐free basis, 3 % lower than the capacity of the high purity Fe2O3‐based material at 0.1 C. The silver bath‐based LFP samples produced cleaner XRD patterns (less than 160 ppm of Ag in the LFP ingots), closer to the estimated molar ratios and neither silver compounds nor silver oxides. In this case, the sample delivered 161 mAh/g of LFP, the same capacity as the cathode prepared without a metallic bath. Starting from a commodity Fe3+ source, future work should explore the silver bath roles as a reactive media, a heating source, a crucible insulator, and a potential contaminant trap for the melt‐synthesis of LiFePO4.
Development of an improved parameter fitting method for planar biaxial testing using rakes
Authors: Fehervary Heleen , Vander Sloten Jos , Famaey Nele 
Published: November 2018

AbstractA correct estimation of the material parameters from a planar biaxial test is crucial since they will affect the outcome of the finite element model in which they are used. In a virtual planar biaxial experiment, a difference can be noticed in the stress calculated from the force measured experimentally at the rakes and the actual stress at the center of the sample. As a consequence, a classic parameter fitting does not result in a correct estimation of the material parameters. This difference is caused by the boundary conditions of the set‐up and is among others dependent on the sample material. To overcome this problem, a new parameter fitting procedure is proposed that takes this difference into account by calculating a finite element–based correction vector. This paper describes the methodology to apply this new parameter fitting procedure on real experimental data from a planar biaxial test using rakes. To this end, image processing is used to extract the experiment characteristics. This information is used to construct a finite element model. Two variations of the new parameter fitting procedure are investigated using two human aortic samples: a basic approach and an image‐based approach. The performance of the method is assessed by the difference between the force measured at the rakes during the experiment and the force at the rakes obtained from the finite element simulation. Both approaches of the new parameter fitting procedure lead to an improved estimation of the sample behavior compared with the classic approach.
Dynamic Organellar Maps for Spatial Proteomics
Authors: Itzhak Daniel N. , Schessner Julia P. , Borner Georg H. H. 
Published: November 2018

AbstractEukaryotic cells are highly compartmentalized and protein subcellular localization critically influences protein function. Identification of the subcellular localizations of proteins and their translocation events upon perturbation has mostly been confined to targeted studies or laborious microscopy‐based methods. Here we describe a systematic mass spectrometry‐based method for spatial proteomics. The approach uses simple fractionation profiling and has two applications: Firstly it can be used to infer subcellular protein localization on a proteome‐wide scale, resulting in a protein map of the cell. Secondly, the method permits identification of changes in protein localization, by comparing maps made under different conditions, as a tool for unbiased systems cell biology. © 2018 by John Wiley & Sons, Inc.
A hybrid multi‐objective firefly and simulated annealing based algorithm for big data classification
Authors: Devi S. Gayathri , Sabrigiriraj M. 
Published: November 2018

SummaryEfficient management of big data becomes challenging in recent decades. Online Feature Selection (OFS) is one type of online learning in contrast to batch learning, allowing a classifier to have small and fixed number of features. The major aim of this work is to introduce an OFS algorithm supported on meta‐heuristic algorithm that exploits the MapReduce paradigm. A novel Hybrid Multi‐Objective Firefly and Simulated Annealing (HMOFSA) algorithm is proposed to select optimal set of features. Therefore, as a first step, the original big dataset is decomposed into blocks of examples in the map phase. Subsequently, HMOFSA algorithm is employed to choose the selected features from examples. After that, the attained partial outcomes will be combined into a final vector of features in the reduce phase and evaluated using Kernel Support Vector Machine (KSVM) classifier. The mentioned OFS approach is analyzed with the help of the well‐known classifiers (Logistic Regression, KSVM and Naïve Bayes) developed within the Spark framework. Experiments were conducted on big datasets, containing 66 million samples and 2000 attributes that confirm the proficiency of proposed work. The proposed KSVM classifier results are measured in terms of the metrics like Precision, Recall, Geometric‐mean (G‐mean), F‐measure, and accuracy.
A possibilistic framework for the detection of terrorism‐related Twitter communities in social media
Authors: Moussaoui Mohamed , Zaghdoud Montaceur , Akaichi Jalel 
Published: November 2018

SummarySince the appearance of social networks, there was a historic increase of data. Unfortunately, terrorists are taking advantage of the easiness of accessing social networks and they have set up profiles to recruit, radicalize, and raise funds. Most of these profiles have pages that exist as well as new recruits to join the terrorist groups, see, and share information. Therefore, there is a potential need for detecting terrorist communities in social networks in order to search for key hints in posts that appear to promote the militants' cause. In order to remedy this problem, we first use a possibilistic‐clustering algorithm that allows more flexibility when assigning a social network profile to clusters (non‐terrorist, terrorist‐sympathizer, terrorist). Then, we introduce a new possibilistic flexible graph mining method to discover similar subgraphs by applying possibilistic similarity rather than using hard structural exact similarity. We experimentally show the efficiency of our possibilistic approach through a detailed process of tweets extract, semantic processing, and classification of the community detection.
Indexes of jaw muscle function in asymptomatic individuals with different occlusal features
Authors: Vozzi Francesca , Favero Lorenzo , Peretta Redento , Guarda‐Nardini Luca , Cocilovo Francesco , Manfredini Daniele 
Published: November 2018

AbstractThis study aims to assess the correlation between indexes of jaw muscle function and dento‐skeletal morphology. A sample of 35 temporomandibular disorders‐free healthy individuals (10 males, mean age 26.7 ± 9.8 years) underwent surface electromyographic (sEMG) assessment of bilateral masseter and temporalis muscles, to evaluate sEMG activity during maximum voluntary clenching (MVC) with a dedicated device (Easymyo®, T.F.R. Technology, Udine, Italy). Four outcome parameters were assessed for each individual: MCV on cotton rolls; MVC on teeth; chewing on right and left sides; clench/relax test. Electromyographic recordings were assessed based on five standardized indexes of muscle function, to evaluate the degree of muscle asymmetry during static and dynamic function (i.e., percentage overlapping coefficient [POC], Impact, Asymmetry, Activation, and Torque). For each individual, the presence of a number of occlusal and skeletal features was assessed: asymmetry of molar class; deviated incisor midline; deep bite; open bite; and crossbite. Skeletal class and vertical dimension of occlusion were also evaluated. Based on normality distribution of data, t test and analysis of variance, when needed, were used to compare muscle function indexes between individuals with and without the different dento‐skeletal features. None of the muscle function indexes (POC, Impact, Asymmetry, Activation, and Torque) was significantly different between individuals with or without the various dental and skeletal features. Gender differences were also not significant (p > 0.05). Despite some minor differences were observed, none of them was significant. Thus, the interaction between form and function is too complex for hypothesizing a simple one‐to‐one relationship between interarch tooth relationship and muscle function patterns.