bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does hip morphology correlate with proximal femoral fracture type?
Authors: Rotem Gilad , Sharfman Zachary T , Rath Ehud , Gold Aviram , Rachevsky Gil , Steinberg Ely , Drexler Michael , Haviv Barak , Amar Eyal 
Published: July 2019

Purpose: To determine if boney morphology influences the anatomic location of hip fractures in elderly patients. Methods: All patients with hip fractures between 2008 and 2012 who had hip radiographs taken prior to the fracture were reviewed. Fractures were classified as intracapsular or extracapsular and hip morphology was measured on the pre-fracture x-rays. Hip morphology was determined by alpha angle, lateral central edge angle, acetabular index, neck-shaft angle, hip axis length, femoral neck diameter, Tönnis classification for hip osteoarthritis (OA) and the presence of a crossover sign. Results: 148 subjects (78.4% female, age 83.5 years) with proximal femur fractures were included. 44 patients (29.7%) had intracapsular fractures and 104 (70.3%) had extracapsular fractures. 48% of patients had previous hip fractures on the contralateral side and 74.6% had the same type of fracture bilaterally. The rates of bilateral intracapsular and extracapsular fractures were similar (33.7% vs. 40.9% respectively, p = 0.39). Extracapsular fractures had a statically significant higher neck-shaft angle, a shorter hip axis length, a narrower femoral neck diameter and a higher grade of Tönnis classification of OA ( p = 0.04, 0.046, 0.03, 0.02 respectively). Acetabular coverage and the proximal femoral head-neck junction, which were evaluated by lateral centre-edge angle (LCEA), acetabular index and the presence of a crossover sign, did not correlate with fracture type. The alpha angle > 40° had a statistically significant higher likelihood for extracapsular fractures ( p = 0.013). Conclusions: Acetabular coverage and proximal femoral head-neck junction morphology, were found to partially correlate with the location of hip fractures and do not fully elucidate fracture type susceptibility.
Burden of drug use for gastrointestinal symptoms and functional gastrointestinal disorders in France: a national study using reimbursement data for 57 million inhabitants
Authors: Tuppin Philippe , Rivière Sébastien , Deutsch David , Gastaldi-Menager Christelle , Sabaté Jean-Marc 
Published: July 2019

Background: Gastrointestinal therapeutic drugs (GTDs) are extensively prescribed. The aim of this study was to investigate the characteristics of GTD use in a large population: the French general health scheme beneficiaries (87% of the 66 million inhabitants) in 2016. Methods: The national health data system was used to identify individual characteristics, diseases and GTD classes reimbursed, together with the costs, using anatomical therapeutic chemical class. Results: Among the 57.5 million individuals included, 45% received at least one reimbursement among the 130 million prescriptions reimbursed (90% prescribed by a general practitioner): proton-pump inhibitors (PPI; A02BC: 24%), drugs for functional gastrointestinal disorders (A03: 20%), drugs for constipation (A06: 10%), antidiarrheals, intestinal anti-inflammatory/anti-infective agents (A07: 10%), antiemetics and antinauseants (A04: 7%), other drugs for acid-related disorders (A02X: 6%), other drugs for peptic ulcer and gastro-oesophageal reflux disease (A02BX: 4.5%), antacids (A02A: 1.5%). The overall cost of reimbursed GTDs was €707 million and the mean cost per user was €28. Marked variations were observed according to age, sex, and disease. The rates of at least one reimbursement among infants were A07: 28%, A03: 17%, A02BX: 9%, A02X: 7%, A02BC: 6% and A06: 5%. Women more frequently received a reimbursement than men for each GTD class. Reimbursement rates also varied according to health status (end-stage renal disease A02BC: 66%, pregnancy A03: 53%, A04: 11%), treatments (people with at least six reimbursements for nonsteroidal anti-inflammatory drugs in 2016 A02BC: 62%). Chronic GTD use (>10 reimbursements/year) was observed in 19% of people with at least one A02BC reimbursement, A02BX: 11%, A03: 7%, A04: 2%, A06: 17% and A07: 3%. Conclusions: This study demonstrates extensive and chronic use of GTD in France, raising the question of their relevance according to current guidelines. They must be disseminated to general practitioners, who are the main prescribers of these drugs.
The prevalence of personality disorders in the community: a global systematic review and meta-analysis
Authors: Winsper Catherine , Bilgin Ayten , Thompson Andrew , Marwaha Steven , Chanen Andrew M. , Singh Swaran P. , Wang Ariel , Furtado Vivek 
Published: July 2019

BackgroundPersonality disorders are now internationally recognised as a mental health priority. Nevertheless, there are no systematic reviews examining the global prevalence of personality disorders.AimsTo calculate the worldwide prevalence of personality disorders and examine whether rates vary between high-income countries and low- and middle-income countries (LMICs).MethodWe systematically searched PsycINFO, MEDLINE, EMBASE and PubMed from January 1980 to May 2018 to identify articles reporting personality disorder prevalence rates in community populations (PROSPERO registration number: CRD42017065094).ResultsA total of 46 studies (from 21 different countries spanning 6 continents) satisfied inclusion criteria. The worldwide pooled prevalence of any personality disorder was 7.8% (95% CI 6.1–9.5). Rates were greater in high-income countries (9.6%, 95% CI 7.9–11.3%) compared with LMICs (4.3%, 95% CI 2.6–6.1%). In univariate meta-regressions, significant heterogeneity was partly attributable to study design (two-stage v. one-stage assessment), county income (high-income countries v. LMICs) and interview administration (clinician v. trained graduate). In multiple meta-regression analysis, study design remained a significant predictor of heterogeneity. Global rates of cluster A, B and C personality disorders were 3.8% (95% CI 3.2, 4.4%), 2.8% (1.6, 3.7%) and 5.0% (4.2, 5.9%).ConclusionsPersonality disorders are prevalent globally. Nevertheless, pooled prevalence rates should be interpreted with caution due to high levels of heterogeneity. More large-scale studies with standardised methodologies are now needed to increase our understanding of population needs and regional variations.
Antiparallel Arrangement of 2,7-Substituted 9,10-Bis(phenylethynyl)anthracene Assisted by Hydrogen Bonding of Terminal Units
Authors: Kaneko Takashi , Araki Yosuke , Shinohara Ken-ichi , Teraguchi Masahiro , Aoki Toshiki 
Published: July 2019

Abstract
2,7-Substituted 9,10-bis(phenylethynyl)anthracenes with bulky phenol residues were synthesized and investigated for their antiparallel molecular arrangement. UV-vis absorption and photoluminescence properties and molecular mechanics calculation indicate that they formed an antiparallel π-π stacked dimer, which was strongly associated by hydrogen bonding and π-π interaction. This strongly associated dimer structure was supported by AFM images of specimens prepared on mica by spin casting dilute chloroform/hexane (2/8 v/v) solution. However, the absence of intradimer hydrogen bonding resulted in the offset stacking, which was confirmed from the single crystal X-ray analysis.
Identification of Intermediates in Peroxidase Catalytic Cycle of a DNAzyme Possessing Heme
Authors: Shinomiya Ryosuke , Araki Haruka , Momotake Atsuya , Kotani Hiroaki , Kojima Takahiko , Yamamoto Yasuhiko 
Published: July 2019

Abstract
Heme in the ferric state (heme(Fe3+)) binds to G-quadruplex DNAs to form stable complexes that exhibit enhanced peroxidase activities. The complexes are considered DNAzymes possessing heme as a prosthetic group (heme-DNAzymes), and have been extensively investigated as promising catalysts for a variety of applications. On ESR and stopped-flow measurements, an iron(IV)oxo porphyrin π-cation radical known as Compound I was detected in reaction mixtures of heme-DNAzymes and hydrogen peroxide. This finding not only resolved the long-standing issue of the mechanism underlying the enhancement of the peroxidase activity of heme(Fe3+) in the scaffold of a G-quadruplex DNA, but also provided new insights as to the design of novel heme-DNAzymes.
Proximate and antioxidant activities of bio-preserved ogi flour with garlic and ginger
Authors: Olaniran Abiola F. , Abiose Sumbo H. 
Published: July 2019

Background: Ogi from locally available cereals remains a relatively affordable complementary food in West Africa, but has a tendency to spoil due it high moisture content. This study explored effects of garlic and ginger as biopreservatives in ogi flour. Methods: Ogi flour was prepared from sorghum and quality protein maize grains with different concentrations of garlic and ginger powder (2 and 4% w/w) by fermentation technique. These samples were stored for 16 weeks during which the total titratable acidity, pH, proximate composition, mineral content and total antioxidant activities were determined. Results: The proximate compositions of bio-preserved ogi samples were relatively stable throughout storage. The addition of garlic and ginger slightly increased the ash (0.04%), crude protein and mineral contents (mg/ 100g) of the samples. Magnesium (10.85-13.13 and 5.17-9.72); zinc (1.37-1.78 and 7.01-8.50), manganese (1.30-1.71 and 0.45-0.86) and iron (1.53-1.77 and 0.68-2.77) contents increased on addition (of garlic and ginger) to maize ogi and sorghum ogi flours respectively. The free radical scavenging activity; total phenolic and flavonoid contents increased correspondingly with the antioxidants activity. Conclusion: Although not well known to ogi consumer, the bio-preserved ogi flours showed better nutritional values and have potential as a health food.
Expectativas, necesidades y tendencias de la formación en educación superior en Colombia en pregrado y posgrado: entre la deserción– perfil y vocación profesional
Authors: Gutierrez Ossa Jahir Alexander , Mondragón Morales Viviana Hercilia , Santacruz Montenegro Laura Carolina 
Published: July 2019

El escrito evalúa las condiciones que presenta la educación de pregrado y posgrado, para acercar los conceptos de economía y mercado a la educación superior en Colombia. Esta última, es impartida bajo la óptica conductual y funcionalista, sin albergar espacio para propósitos reales. El análisis multicriterio, sirve de fundamento metodológico para plantear la evaluación. Los temas a tratar responden, al estado del arte en materia de evaluación de la educación superior. Seguido, de los impactos y resultados obtenidos de la evaluación internacional en ambos grados educativos. Y finalmente, el espacio que tiene el pregrado y posgrado para medirse en términos de la economía y el mercado de la educación en Colombia. La educación superior tiene dificultades para mostrarse positiva
EVALUATION OF THE ENVIRONMENTAL STATE OF THE WESTERN SECTOR OF SEPETIBA BAY (SE BRAZIL): TRACE METAL CONTAMINATION
Authors: Díaz Morales Shéron Joyce , Guerra Josefa Varela , Nunes Márcia Andréia Da Silva , Souza Ariadne Marra de , Geraldes Mauro César 
Published: July 2019

Sepetiba Bay located in Rio de Janeiro State (RJ), Southeast Brazil, is a region under heavy influence of seaports and mining. This feature puts at risk the quality of the local water system, especially due to the deposition of trace metals on the sediments. This work aimed to report the values of total concentrations of Ag, As, Cd, Co, Cr, Cu, Li, Mn, Ni, Pb, Sr, Zn and Hg obtained in bottom surface sediments collected in Nov/2010 in the Western sector of Sepetiba Bay, through the Plasma Spectrometer (ICP-OES). The average concentrations of Ag (0.40 µg/g), Cd (0.76 µg/g), Cu (62.59 µg/g), Li (43.29 µg/g), Ni (16.65 µg/g), Pb (20.08 µg/g), Sr (389.64 µg/g) and Zn (184.2 µg/g) exceeded the limits allowed by Brazilian legislation, and are, in addition, above the natural values found in Ribeira Bay (RJ), the considered control region. It is necessary to monitor this area, due to its economic and environmental importance. AVALIAÇÃO DO ESTADO AMBIENTAL DO SETOR OCIDENTAL DA BAÍA DE SEPETIBA (SE BRASIL): CONTAMINAÇÃO POR METAIS TRACEResumoA Baía de Sepetiba localizada no Estado do Rio de Janeiro (RJ), sudeste do Brasil, é uma região sob forte influência de portos marítimos e mineração. Esta característica coloca em risco a qualidade do sistema de água local, especialmente devido à deposição de metais traço nos sedimentos. Este trabalho tem como objetivo reportar os valores das concentrações totais de Ag, As, Cd, Co, Cr, Cu, Hg, Li, Mn, Ni, Pb, Sr, U e Zn obtidos em sedimentos de superfície de fundo coletados em Nov / 2010 no Setor Oeste da Baía de Sepetiba, através do Espectrômetro de Plasma (ICP-OES). As concentrações médias de Ag (0,40 µg / g), Cd (0,76 µg / g), Cu (62,59 µg / g), Li (43,29 µg / g), Ni (16,65 µg / g), Pb (20,08 µg / g ), Sr (389,64 µg / g) e Zn (184,2 µg / g) ultrapassaram os limites permitidos pela legislação brasileira, e estão, além disso, acima dos valores naturais encontrados na Baía da Ribeira (RJ), a região de controle considerada. É necessário monitorar esta área, devido à sua importância econômica e ambiental. Palavras-chave: Total Trace Metals. Sedimentos Litoral. Contaminação
Evaluation of rituximab therapy in real clinical practice (according to the OREL registry of patients with rheumatoid arthritis
Authors: Avdeeva A. S. , Satybaldyev A. M. , Demidova N. V. , Nikishina N. Yu. , Gerasimova E. V. , Muravyeva N. V. , Gridneva G. I. , Rumyantseva O. A. , Kasumova K. A. , Alekseeva A. V. , Chichasova N. V. , Kusevich D. A. , Rybakova V. V. , Koshkarova E. A. , Lila A. M. , Nasonov E. L. 
Published: July 2019

Objective:to analyze therapy with rituximab (RTM) in real clinical practice according to the data available in OREL registry of patients with active rheumatoid arthritis (RA).Subjects and methods. The analysis included 349 patients. All the patients received RTM: 340 – the original drug (MabThera®) and 9 – the biosimilar Acellbia®. 263 patients (75.4%) received RTM in combination with disease-modifying anti-rheumatic drugs (DMARDs) and 86 (24.6%) – RTM as monotherapy.Results and discussion. Of the 349 patients included in the analysis, 272 (77.9%) patients received RTM as the first biologic agent (BA) (263 patients were treated with the original drug and 9 – with the biosimilar) and 77 (22.1%) patients had previously used the BA. The majority of patients (n=205 (58.7%)) received three or more; 109 (31.2%) patients – one, and 35 (10%) – two RTM courses of RTM therapy. RTM caused a significant reduction in disease activity just after the first therapy course and in the levels of acute-phase reactants (C-reactive protein (CRP) and ESR); after the fifth therapy course, median CRP concentration decreased by 1.4 times and amounted to 7 [1.2; 17.9] mg/l and that of ESR reduced by 1.8 times and was 10 [5; 20] mm/hr (p<0.05).Conclusion.The analysis of RTM therapy in RA patients in real clinical practice demonstrated that in most cases RTM was given as the first BA, in combination with DMARDs, the main agent of which was methotrexate. The use of RTM was accompanied by a significant reduction in disease activity and in the serum levels of acute-phase reactants and autoantibodies.
Time course of changes in the clinical and instrumental manifestations of coxitis in patients with ankylosing spondylitis during golimumab therapy: a GO-COX study. Preliminary results
Authors: Erdes Sh. , Dubinina T. V. , Agafonova E. M. , Rumyantseva D. G. , Davidyan S. Yu. , Zemerova E. V. , Kulikov A. I. , Markova O. G. 
Published: July 2019

Objective: to evaluate the effect of golimumab (GLM) on the clinical, functional, and instrumental manifestations of coxitis in ankylosing spondylitis (AS).Subjects and methods. The non-interventional prospective multicenter cohort study GO-COX conducted in the medical centers of the Russian Federation enrolled 39 patients with AS (meeting the modified New York criteria) and coxitis with BASRI-hip score 0–2, who were prescribed GLM as the first biologic agent at a dose of 50 mg per month. The patient's health status was assessed using the Bath Ankylosing Spondylitis Functional Index (BASFI), the Bath Ankylosing Spondylitis Metrology Index (BASMI), the Ankylosing Spondylitis Disease Activity Score-C-Reactive Protein (ASDAS-CRP), and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) before and at 6 and 12 months after GLM treatment initiation. Based on the data of radiographs (the Bath Ankylosing Spondylitis Radiology Hip Index (BASRI-hip) scoring system), ultrasonography (USG), and STIR and T1 magnetic resonance imaging (MRI), the investigators assessed the manifestations of coxitis. The planned follow-up duration was 2 years. This paper includes 12-month follow-up results in 22 patients.Results and discussion. At 12 weeks of GLM therapy, there were significant positive index changes: a decrease in BASDAI by an average of 3.28±1.62, in ASDAS-CRP by 2.20±0.95, in BASFI by 2.52±2.09, and in BASMI by 1.41±1.50 (p<0.0001). One year after GLM therapy initiation, the BASRI-hip values remained unchanged; 40 to 60% of patients had no MRI and USG signs of coxitis.Conclusion. At 12 weeks, GLM therapy in patients with AS and coxitis provided a reduction in the clinical and instrumental signs of coxitis, as evidenced by MRI and USG (a significant decline in the proportion of patients with subchondral bone edema and intraarticular effusion), and also effectively suppressed other manifestations of inflammatory activity.
Nonradial Solutions for the Hénon Equation Close to the Threshold
Authors: Figueroa Pablo , Neves Sérgio L. N. 
Published: July 2019

Abstract
We consider the Hénon problem

{

-

Δ
⁢
u

=

|
x
|

α

⁢

u

N
+
2
+

2
⁢
α

N
-
2

-
ε

in
⁢

B
1

,

u
>
0

in
⁢

B
1

,

u
=
0

on
⁢

∂
⁡

B
1

,

\left\{\begin{aligned} &\displaystyle{-}\Delta u=\lvert x\rvert^{\alpha}u^{% \frac{N+2+2\alpha}{N-2}-\varepsilon}&&\displaystyle\phantom{}\text{in }B_{1},% \\ &\displaystyle u>0&&\displaystyle\phantom{}\text{in }B_{1},\\ &\displaystyle u=0&&\displaystyle\phantom{}\text{on }\partial B_{1},\end{% aligned}\right.

where

B
1

{B_{1}}

is the unit ball in

ℝ
N

{\mathbb{R}^{N}}

and

N
⩾
3

{N\geqslant 3}

. For

ε
>
0

{\varepsilon>0}

small enough, we use α as a parameter and prove the existence of a branch of nonradial solutions that bifurcates from the radial one when α is close to an even positive integer.
Kaserne, Platz und Forum. Manifestationen einesacademical village
Authors: Thomas Lil Helle 
Published: July 2019

AbstractThomas Jefferson coined the image of the academical village for the university-campus. Whereupon the word village can be translated into the German expression ›Dorf‹ (village) as well as ›Gemeinde‹ (community). Thus the place and people, who enliven their surroundings, are an integral part of the campus. This metaphor gathers the cultural imprint of the campus as an ideal environment for learning as well as its incorporated imaginations. This article follows the question, if the buildings of a university can be seen as a result of the social structures of the academical village. Perhaps they were intended from the beginning on as a production of these social configurations. Therefore this paper wants to inquire specifically into the expressiveness of architecture in the specific case of the early Saarbrücken campus planning of the Universität des Saarlandes. The field of tension university shall be approached as a topic between representative institution and architectural manifestation.
Building environmental history for Naval aircraft
Authors: Nickerson William C. , Amiri Mehdi , Iyyer Nagaraja 
Published: July 2019

Abstract
The operating environment of Navy aircraft varies to a good degree depending upon the squadron location, flight requirements, and other field and ground activities. All these conditions promote corrosion of one type or the other. The aircraft operations will also have influence on the type of corrosion. Thus, building an environment history that can monitor and track the damage development in many areas of the aircraft structure based on aircraft activities, operating environment, and service history data is crucial. The development of such environmental history builder has two main advantages: first, it provides a tool to treat corrosion as a structural issue, and second, it accounts for time variation of environmental factors such as relative humidity (RH) and temperature rather than average environmental data. This paper will demonstrate how the environmental history builder could be used, in conjunction with predictive models, to predict corrosion damage.
CFD Modeling to Predict Mass Transfer in Multicomponent Mixtures
Authors: Lavasani Mitra Sadat , Rahimi Rahbar , Zivdar Mortaza , Kalbassi Mohammad 
Published: July 2019

AbstractA novel three-dimensional computational fluid dynamics mass transfer (CMT) model in Eulerian–Eulerian frame work is deploys for investigating the concentration profiles, and trays efficiencies in multicomponent distillation columns. The proposed model is based on Maxwell Stefan equations, and CFD was employed as a powerful tool to model the hydrodynamics and mass transfer. The two phases are modelled as two interpenetrating phases with interphase momentum, heat and mass transfer. The Closure model is developed for mass interphase transfer rate in ternary mixtures. The predictability of the mass transfer behaviours of multicomponent can result in a more efficient and predictable design of distillation trays. Two non-ideal ternary mixtures were studied. The tray geometry and operating conditions are based on the experimental works of Kalbassi and the composition profiles, tray efficiencies, and point efficiencies of mixtures were presented. The obtained results were confirmed by the experimental data. The results indicate that the values of individual component tray efficiencies and point efficiencies for these multicomponent systems were considerably different which confirm the interactive nature of the mass transfer in multicomponent mixtures. These mixtures also illustrated different point efficiencies across the tray because of the composition dependency of these mixtures. The average relative error for the prediction of efficiencies is about 8 %, which indicates the accuracy of the model.
Real-Time Map Matching: A New Algorithm Integrating Spatio-Temporal Proximity and Improved Weighted Circle
Authors: Teng Wenxin , Wang Yanhui 
Published: July 2019

Abstract
Previous real-time map matching algorithms for in-vehicle navigation systems had some efficiencies and defects on time lagging and low accuracy. As a response, this paper proposes a new algorithm that integrates STP (spatio-temporal proximity) and IWC (improved weighted circle), in which the new algorithm proposes STP to dynamically refine candidate matching roads, and IWC to adaptively identify the optimal matching road. Specifically, three spatio-temporal proximity indicators are defined in STP to build a three-dimensional stereoscopic cone, and then the two-dimensional projection of the cone are adopted to dynamically select the candidate matching roads. Further, by adaptively setting the weight, the IWC algorithm is developed to integrate three new parameters to adaptively determine the optimal matching road. The test results show that the matching accuracy of the algorithm is over 95%, much higher than that of the existing algorithm, which demonstrates the feasibility and efficiency of the new algorithm.