bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conclusion
Authors: Damkjær Maria 
Published: November 2024

Abstract
The Conclusion builds on the idea of the print imaginary, to argue that mid-nineteenth-century print culture uses genre hybridity to suggest that the printed product is an exact fit with readers’ lives. In the print imaginary, readers are flattered by the suggestion that they are not only already readers, but already editors and writers in their own right. The Conclusion also expands on the idea of the print imaginary as a realm that is peopled by characters—fictional, but by definition life-like—who embody print’s ability to transform (idealized) lives. By sublimating the printed object into both a material product and a way of life, the magazine presents a fantasy of the heroic reading and making of print. Finally, the Conclusion argues for the values of literary genres that never caught on.
Social determinants of health and variability in treatment for patients with early-stage Non-Small Cell Lung Cancer
Authors: Scannell Bryan Molly , Hu Xiaohan , Izano Monika A , Mohammed Hina , Wicks Marianna , Brown Thomas , Simon George , Kaplan Henry , Berry Anna 
Published: November 2024

Abstract

Background
In non-small cell lung cancer (NSCLC), social determinants of health (SDOHs) influence treatment, but SDOHs with geographic precision are infrequently used in real-world research due to privacy considerations. This research aims to characterize the influence of census-tract level SDOHs on treatment for stage I and IIa NSCLC.

Methods
Patients diagnosed between 1/1/17 and 9/30/22 with stages I and IIa NSCLC in the Syapse Learning Health Network had their addresses geocoded and linked to five census tract-level indicators of SDOH (social vulnerability index (SVI), percent (%) housing burden, % broadband internet access, primary care shortage area, and rurality). Clinical and demographic characteristics were ascertained from medical records. Nested multinomial logistic regression models estimated associations between SDOHs and initial treatment using two-sided Wald tests. The collective statistical significance of SDOHs was assessed with a likelihood ratio test (LRT) comparing nested models. Descriptive statistics described time-to-treatment-initiation.

Results
Among 3595 patients, 58% were initially treated with surgery, 29% with radiation, and 12% with “other.” Two SDOH variables were associated with increased relative risk ratios (RRR) for radiation therapy compared to surgery: living in primary care shortage areas (RRR 1.61, 95% CI: (1.23-2.10)) and living in non-metropolitan areas (RRR 1.45 (1.02-2.07)). The LRT suggested that the five SDOH variables collectively improved the treatment model. Further, patients in areas with high SVI, low internet access, and high housing-burden initiated treatment later.

Conclusion
When using precise estimates of geospatial SDOHs, these measures were associated with treatment, and should be considered in analyses of cancer outcomes.
Management of retained endoscopy capsule: a case series and literature review
Authors: Palm Preston H , Patrick Madison M , Cruz Claudia A , Navaneethan Udayakumar , Caycedo Antonio , Ferrara Marco 
Published: November 2024

Abstract
Video capsule endoscopy has become the gold standard for the evaluation of small bowel pathology. Capsular retention remains the most significant risk of this intervention. Here, we present two cases of retained capsules and our minimally invasive approach to retrieval. We also review the literature pertaining to retained endoscopy capsules and highlight a range of medical, surgical, and preventative strategies utilized in its management.
Percutaneous Release of Trigger Finger Under Local Anesthesia
Authors: Abdelhamed Romeih Mohamed 
Published: November 2024

Objective:
The trigger finger involves the hindrance of the flexor tendon in the hand, commonly leading to pain, discomfort, and dysfunction in the hand. This work aimed to assess the results of percutaneous release using local anesthesia for the treatment of the trigger finger.

Patients and Methods:
This single-arm trial was carried out on 30 patients, aged 18 years old, both sexes, and diagnosed by clinical assessment by the percutaneous release of A1 pulley of the diseased finger with a history of triggering for at least 3 months and failure of previous steroid injection into the flexor sheath at least once.

Results:
The complications were pain in 10%, swelling in 13.33%, numbness in 3.33% of the patients, triggering, stiffness, digital nerve injury, scar, and recurrence were not present in any patients. Patient satisfaction was poor in 26.67%, good in 16.67%, and excellent in 56.67% of the patients. Age, sex, duration of symptoms, occupation, hand side, grade, and finger affection were insignificantly different among the 3 groups.

Conclusion:
The percutaneous release of the trigger finger under local anesthesia can be a safe and effective treatment for the trigger finger, applicable to a broad range of patients indicating a generally favorable outcome with minimal complications and higher satisfaction rates.
Invasive Squamous Cell Carcinoma of the Nipple: Case Report With Literature Review
Authors: Potter Scott , Gulbahce Evin , Porretta Jane , Lomo Lesley , Duffy Keith , Winkler Nicole , Coleman Joshua , Jedrzkiewicz Jolanta 
Published: November 2024

Abstract:
In this unusual case, a 73-year-old woman presented with bloody discharge from her right breast and skin thickening was observed on subsequent imaging. Clinically, the findings raised concern for Paget disease. A skin punch biopsy was performed, revealing a high-grade infiltrating carcinoma with squamous features. Metaplastic carcinoma was a differential diagnosis, given that this patient had a history of invasive ductal carcinoma and radiation treatment in the same breast. A subsequent central lumpectomy confirmed the diagnosis of invasive squamous cell carcinoma of the nipple, occurring in the context of Bowen disease as a precursor lesion. Notably, there was no evidence of ductal carcinoma in situ in the background breast tissue or conventional invasive ductal carcinoma component. Both in situ and invasive forms of squamous cell carcinomas have been rarely reported in the nipple. This case highlights the importance of considering such a rare diagnosis, especially in patients with a history of breast cancer.
Von Hippel-Lindau deficiency protects the liver against ischemia/reperfusion injury through the regulation of hypoxia-inducible factor 1α and 2α
Authors: Li Zihao , Yin Bing , Xu Yanan , Wang Chaoqun , Li Xinglong , Lu Shounan , Ke Shanjia , Qian Baolin , Yu Hongjun , Bai Miaoyu , Li Zhongyu , Zhou Yongzhi , Jiang Hongchi , Ma Yong 
Published: November 2024

Background:
Ischemia and reperfusion (I/R)-induced liver injury contributes to morbidity and mortality during hepatic surgery or liver transplantation. As a pivotal regulator of cancer and inflammation, the role of Von Hippel-Lindau (VHL) in hepatic I/R injury remains undetermined.

Methods:
We investigated the role of VHL in hepatic I/R injury by generating VHL conditional knockout (VHL-KO) mice. The downstream mechanisms of VHL were confirmed, and the role of HIF-2α in hepatic I/R injury was further investigated.

Results:
In this study, we discovered that VHL upregulation was associated with hepatic I/R injury in a mouse model. VHL gene knockout (VHL-KO) and overexpression (Ad-VHL) mice demonstrated that VHL aggravated liver injury, increased inflammation, and accelerated cell death in hepatic I/R injury. The VHL protein (pVHL) regulates a crucial control mechanism by targeting HIFα subunits for ubiquitin-mediated degradation. In vitro and in vivo studies demonstrated that VHL interacted with and repressed hypoxia-inducible factor 1α (HIF-1α) and hypoxia-inducible factor 2α (HIF-2α) expression during hepatic I/R injury. Notably, the inhibition of HIF-1α or 2α, as well as the concurrent inhibition of HIF-1α and 2α, abrogated the protective effect of VHL-KO. The severe stabilization of HIF-1α or 2α, as well as the simultaneous overexpression of HIF-1α and 2α, compensated for the detrimental effect of VHL.

Conclusions:
Thus, we identified the VHL-HIF-1α/HIF-2α axis as an indispensable pathway that may be a novel target for mediating hepatic I/R injury.
The Barriers and Enablers to Participation in Oncology Clinical Trials for Ethnically Diverse Communities
Authors: Turner Lorraine , Taylor Sally , Ward Ashleigh , Thistlethwaite Fiona , Yorke Janelle 
Published: November 2024

Background
Racial and ethnic inequities exist in cancer clinical trial participation. Low recruitment across ethnically diverse communities contributes to health inequalities further disproportionately affecting these groups. Understanding barriers and enablers to clinical trial participation for ethnic minorities is key to developing strategies to address this problem.

Objective
To explore, evaluate, and synthesize qualitative research surrounding patients’ lived experiences and perceptions of participating in cancer clinical trials from ethnically diverse groups.

Methods
Noblit and Hare’s 7-stage metaethnography was used. Seven databases were searched. Inclusion criteria were as follows: qualitative studies published in English from January 1, 2012, to January 31, 2022; patients from any ethnic minority 18 years and older with a cancer diagnosis; and cancer patients’ carers and healthcare professionals (HCPs)/healthcare leaders involved in the delivery of cancer clinical trials.

Results
The majority of included articles were conducted in the United States. Interpretive qualitative synthesis resulted in 7 categories including patient perceptions and beliefs and HCP perception of trial burden and social determinants of health. Four lines of argument were established.

Conclusions
The findings capture the experience and perceptions of ethnic minority patients, their carers, HCPs, and healthcare leaders in this area of research. Incongruities exist between patient-reported barriers and those perceived by HCPs. Published empirical research outside the United States is limited.

Implications for Practice
When developing strategies to increase clinical trial participation, research literacy, cultural safety, and unconscious biases within healthcare need to be addressed. Further research to examine intersectionality and the role of faith in decision-making among ethnic groups is warranted.
Shear Wave Elastography in the Assessment of Liver Iron Overload in Children With Beta Thalassemia Major
Authors: Eker Nurşah , Turkay Rüştü , Özdemir Sevim , Taş Burcu Tufan , Ocak Süheyla , Canpolat Aylin , Altaş Zeynep , Koç Ahmet 
Published: November 2024

Abstract
Shear wave elastography (SWE) is an ultrasound method that effectively demonstrates liver fibrosis. This prospective study aimed to compare magnetic resonance imaging T2* and SWE results of the liver in children with thalassemia major (TM). Patients with TM who had regular follow-ups were included. SWE was performed first, followed by MRI T2*. In addition, a healthy control group of the same age group, known to have no liver disease, was recruited. For these participants, only SWE was performed, and their results were compared with the SWE parameters of the TM patients. The study included 38 patients and 25 individuals who made up the control group. The groups with mild, moderate, and severe iron overload according to MRI T2* were compared in terms of SWE with parameters, and no statistically significant difference was found. However, when comparing the SWE parameters between the control group and patients, the median, average, and standard values were found to be statistically significantly higher in the patient group (P < 0.001, P < 0.001, P = 0.026). When comparing MRI T2* results, the median, average, and standard values were found to be statistically significantly higher in the patients with normal and mild iron overload (P < 0.001, P < 0.001, P = 0.033). SWE is an effective, more accessible, and easy-to-apply method for demonstrating early changes in the liver in pediatric patients with TM. This study serves as a guide for more comprehensive studies that may investigate the effect of SWE in this patient group.
phenotypic and Genotypic Detection of Carbapenemases in Clinical Isolates ofAcinetobacter baumannii
Authors: Rahi Alya Amer 
Published: November 2024

AbstractAcinetobacter baumannii,a Gram-negative coccobacillus with a short and round rod-like shape, is an opportunistic pathogen in immunocompromised patients, particularly prevalent as a nosocomial infection. A notable characteristic is its diverse antibiotic resistance mechanisms. The isolation ofA. baumanniistrains in hospitals is becoming more prevalent, presenting an escalating challenge in the treatment process. In the present study involving isolates obtained from diverse sources (blood, urine, wound, and burn swabs), the Antimicrobial Susceptibility Testing (AST) results for(28)Acinetobacter baumanniiisolates revealed pronounced resistance. Notably, resistance rates were notably high for piperacillin (80%) and carbenicillin (81’.2%). Resistance to Imipenem and meropenem stood at 8.4% and 19.8%, respectively, while the highest resistance was recorded against gentamicin (82%), amikacin (72.6%), cefepime (60.8%), cefotaxime (70.2%), ceftazidime (70.2%), and ceftriaxone (71.6%). Molecular detection of Enzymatic genes was executed through PCR testing, revealing that, All 28 isolates (100%) exhibited the presence of theblaOXA-51type gene, a considered pointer for finding of bacteria by PCR. The prevailing MBL gene wasblaVIM-type, identified in 12(42.8)% of isolates. Furthermore, 10(35.7%)of isolates carried theblaKPC-gene. In conclusion the identification of these genes (blaOXA-51,blaVIM,andblaKPC-type) inAcinetobacter baumannii. Addressing antibiotic-resistant bacteria challenges healthcare; crucial to understand, monitor, and regulate antibiotic resistance gene dissemination for public health.
Replication stress marker phospho-RPA2 predicts response to platinum and PARP inhibitors in homologous recombination-proficient ovarian cancer
Authors: Schab Angela , Compadre Amanda , Drexler Rikki , Loeb Maggie , Rodriguez Kevin , Brill Joshua , Harrington Shariska , Sandoval Carmen , Sanders Brooke , Kuroki Lindsay , McCourt Carolyn , Hagemann Andrea R. , Thaker Premal , Mutch David , Powell Matthew , Serra Violeta , Hagemann Ian S. , Walts Ann E. , Karlan Beth Y. , Orsulic Sandra , Fuh Katherine , Sun Lulu , Verma Priyanka , Lomonosova Elena , Zhao Peinan , Khabele Dineo , Mullen Mary 
Published: November 2024

ABSTRACTBackgroundOvarian cancer treatment includes cytoreductive surgery, platinum-based chemotherapy, and often poly (ADP-ribose) polymerase (PARP) inhibitors. Homologous recombination (HR)-deficiency is a well-established predictor of therapy sensitivity. However, over 50% of HR-proficient tumors also exhibit sensitivity to standard-of-care treatments. Currently, there are no biomarkers to identify which HR-proficient tumors will be sensitive to standard-of-care therapy. Replication stress may serve as a key determinant of response.MethodsWe evaluated phospho-RPA2-T21 (pRPA2) foci via immunofluorescence as a potential biomarker of replication stress in formalin-fixed, paraffin-embedded tumor samples collected at diagnosis from patients treated with platinum chemotherapy (discovery cohort: n = 31, validation cohort: n = 244) or PARP inhibitors (n = 87). Recurrent tumors (n = 37) were also analyzed. pRPA2 scores were calculated using automated imaging analysis. Samples were defined as pRPA2-High if > 16% of cells had ≥ 2 pRPA2 foci.ResultsIn the discovery cohort, HR-proficient, pRPA2-High tumors demonstrated significantly higher rates of pathologic complete response to platinum chemotherapy than HR-proficient, pRPA2-Low tumors. In the validation cohort, patients with HR-proficient, pRPA2-High tumors had significantly longer survival after platinum treatment than those with HR-proficient, pRPA2-Low tumors. Additionally, the pRPA2 assay effectively predicted survival outcomes in patients treated with PARP inhibitors and in recurrent tumor samples.ConclusionOur study underscores the importance of considering replication stress markers alongside HR status in therapeutic planning. Our work suggest that this assay could be used throughout a patient’s treatment course to expand the number of patients receiving effective therapy while reducing unnecessary toxicity.
Impact of artificial intelligence and knowledge management on proactive green innovation: the moderating role of trust and sustainability
Authors: Abdulmuhsin Amir A. , Hussein Hayder Dhahir , AL-Abrrow Hadi , Masa’deh Ra’ed , Alkhwaldi Abeer F. 
Published: November 2024

PurposeIn this research, we seek to understand the effects of artificial intelligence (AI) and knowledge management (KM) processes in enhancing proactive green innovation (PGI) within oil and gas organizations. It also aims to investigate the moderator role of trust and sustainability in these relationships.Design/methodology/approachThis paper employs a quantitative analysis. Surveys have been gathered from the middle-line managers of twenty-four oil and gas government organizations to evaluate the perceptions of the managers towards AI, KM processes, trust, sustainability measures and proactive measures toward green innovation. Analytical and statistical tools that were employed in this study, including structural equation modeling with SmartPLSv3.9, have been used to analyze the data and to examine the measurement and structural models of this study.FindingsThe study results reveal a significant and positive impact of AI utilization, KM processes and PGI within oil and gas organizations. Furthermore, trust and sustainability turn out to be viable moderators affecting, and influencing the strength and direction of AI, KM and PGI relationships. In particular, higher levels of trust and more substantial sustainability commitments enhance the positive impact of AI and KM on green innovation outcomes.Practical implicationsUnderstanding the impact of AI, KM, trust and sustainability offers valuable insights for organizational leaders and policymakers seeking to promote proactive green innovation within the oil and gas industry. Thus, organizations can increase the efficiency of sustainable product development, process improvement and environmental management by using robust AI technologies and effective KM systems. Furthermore, fostering trust among stakeholders and embedding sustainability principles into organizational culture can amplify the effectiveness of AI and KM initiatives in driving green innovation outcomes.Originality/valueThis study extends the current knowledge by assessing the effect of AI and KM on proactive green innovation while accounting for trust and sustainability as moderators. Utilizing quantitative methods offers a nuanced understanding of the complex interactions between these variables, thereby advancing theoretical knowledge in the fields of innovation management, sustainability and organizational behavior. Additionally, the identification of specific mechanisms and contextual factors enriches practical insights for organizational practitioners striving for a practical understanding of the dynamics of the complexities of sustainable innovation in an AI-driven era.
Local traditions, global ambitions: influence of organizational culture on innovative capability and international growth orientation in Brazilian wineries
Authors: Baldissarelli Juciele Marta , Gomes Giancarlo , Hahn Ivanete Schneider 
Published: November 2024

PurposeThis study examines the influence of organizational culture types, specifically clan, adhocracy, hierarchy and market culture, on innovative capability and a firm’s international growth orientation within Brazil’s wine industry.Design/methodology/approachThe paper builds on empirical evidence gathered from responses of managers from 230 Brazilian winemaking organizations based on a self-administered survey. The hypotheses in the conceptual model are tested using Smart-PLS (partial least square).FindingsThe types of culture that showed a positive relationship with dynamic innovation capability were clan, adhocracy, and market. Regarding the orientation for international growth, the market culture is the most conducive. Clan culture is not ideal for internationalization, and both adhocracy and hierarchical cultures showed no relationship. It was found that dynamic innovation capability has a positive relationship with the orientation for international growth.Practical implicationsThe study broadens the research perspectives for analyzing resources from the Brazilian wine industry, further examining their linkage with the orientation for the international growth of the segment. The findings provide managers with insights about which types of culture should be fostered when aiming to innovate and internationalize.Social implicationsThe advancements are related to the Sustainable Development Goals advocated by the United Nations.Originality/valueThe study is motivated by the lack of integrated methodologies that relate organizational culture, dynamic innovation capability and orientation for international growth. International business research has neglected to specify which particular resources a company needs to have a propensity for international growth orientation.
Analyzing the connectedness between psychological contract, burnout and work engagement using a serial mediation model
Authors: Banerjee Antara , Malik Aradhna 
Published: November 2024

PurposeThis paper aimed to examine the serial mediating effect of psychological contract violation (PCV) and burnout in the relationship between psychological contract breach (PCB) and work engagement. Also, the role of PCV as a mediator was tested in the relationship between PCB and work engagement.Design/methodology/approachData were collected from 536 employees working in various organizations of the manufacturing, consulting, banking, healthcare and mining sectors situated across India using time-lagged surveys. The analysis was carried out using IBM SPSS Statistics Version 22 and IBM SPSS Amos Version 24 software.FindingsWe found positive relationships between PCB and PCV, and PCV and burnout; negative relationships between PCB and work engagement, PCV and work engagement, and burnout and work engagement. PCV partially mediated the relationship between PCB and work engagement. PCV and burnout serially mediated the relationship between PCB and work engagement.Originality/valueThe study tested the effect of PCV generated due to PCB on burnout and work engagement. Also, the study embarks on a unique concept of testing a serial mediating effect of PCV and burnout in the relationship between PCB and work engagement. Furthermore, we tested the mediating effect of PCV in the relationship between PCB and work engagement. Managerial implications for preventing PCB, PCV and burnout are discussed in the article.