bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Sensor Based on Poly (1,2‐Diaminoanthraquinone) for Individual and Simultaneous Anodic Stripping Voltammetry of Cd2+, Pb2+, Cu2+ and Hg2+
Authors: Hassan Khalid Mahmoud , Gaber Seleem Elsaid , Altahan Mahmoud Fatehy , Azzem Magdi Abdel 
Published: March 2018

AbstractA novel electrochemical sensor based on glassy carbon electrode (GCE) modified by poly (1,2‐diaminoanthraquinone) (P1,2‐DAAQ) has been developed for individual and simultaneous determination of Cd2+, Pb2+, Cu2+ and Hg2+ using square wave anodic stripping voltammetry (SWASV). P1,2‐DAAQ was characterized by cyclic voltammetry (CV) and scan electron microscope (SEM). Several analytical parameters such as the type of electrolyte solution, polymer film thickness, metal deposition time and deposition potential were investigated and optimized. Optimal conditions were obtained by using five scan cycles for polymer synthesis and 120 seconds at −1.6 V for metal electrodeposition in acetate buffer solution. Good linear responses to Cd2+, Pb2+, Cu2+ and Hg2+ in the concentration range from 0 to 120 μg/L were obtained. The limit of detections (LOD) for simultaneous determination of Cd2+, Pb2+, Cu2+ and Hg2+ were 0.3 μg/L, 0.58 μg/L, 1.94 μg/L and 0.26 μg/L, respectively. The developed method was also applied for their detection in real water samples for which favorable results obtained compared with those obtained using inductively coupled plasma – optical emission spectroscopy (ICP‐OES).
Body checking and body avoidance in eating disorders: Systematic review and meta‐analysis
Authors: Nikodijevic Alexandra , Buck Kimberly , Fuller‐Tyszkiewicz Matthew , de Paoli Tara , Krug Isabel 
Published: March 2018

AbstractThis review sought to systematically review and quantify the evidence related to body checking and body avoidance in eating disorders (EDs) to gauge the size of effects, as well as examine potential differences between clinical and nonclinical populations, and between different ED subtypes. PsycINFO, PsycARTICLES, PsycEXTRA, Cochrane Library, and MEDLINE databases were searched for academic literature published until October 2017. A grey literature search was also conducted. Fifty‐two studies were identified for the systematic review, of which 34 were eligible for meta‐analysis. Only female samples were included in the meta‐analysis. ED cases experienced significantly higher body checking (d = 1.26, p < .001) and body avoidance (d = 1.88, p < .001) overall relative to healthy controls, but neither behaviour varied by ED subtype. In nonclinical samples, body checking (r = .60) and body avoidance (r = .56) were significantly correlated with ED pathology (p < .001). These findings support transdiagnostic theoretical models and approaches to ED treatment and early intervention programmes.
Heritability of aggression following social evaluation in middle childhood: An fMRI study
Authors: Achterberg Michelle , van Duijvenvoorde Anna C. K. , van der Meulen Mara , Bakermans‐Kranenburg Marian J. , Crone Eveline A. 
Published: March 2018

AbstractMiddle childhood marks an important phase for developing and maintaining social relations. At the same time, this phase is marked by a gap in our knowledge of the genetic and environmental influences on brain responses to social feedback and their relation to behavioral aggression. In a large developmental twin sample (509 7‐ to 9‐year‐olds), the heritability and neural underpinnings of behavioral aggression following social evaluation were investigated, using the Social Network Aggression Task (SNAT). Participants viewed pictures of peers that gave positive, neutral, or negative feedback to the participant's profile. Next, participants could blast a loud noise toward the peer as an index of aggression. Genetic modeling revealed that aggression following negative feedback was influenced by both genetics and environmental (shared as well as unique environment). On a neural level (n = 385), the anterior insula and anterior cingulate cortex gyrus (ACCg) responded to both positive and negative feedback, suggesting they signal for social salience cues. The medial prefrontal cortex (mPFC) and inferior frontal gyrus (IFG) were specifically activated during negative feedback, whereas positive feedback resulted in increased activation in caudate, supplementary motor cortex (SMA), and dorsolateral prefrontal cortex (DLPFC). Decreased SMA and DLPFC activation during negative feedback was associated with more aggressive behavior after negative feedback. Moreover, genetic modeling showed that 13%–14% of the variance in dorsolateral PFC activity was explained by genetics. Our results suggest that the processing of social feedback is partly explained by genetic factors, whereas shared environmental influences play a role in behavioral aggression following feedback.
Task sharing in the eye care workforce: Screening, detection, and management of diabetic retinopathy in Pakistan. A case study
Authors: Shah Mufarriq , Noor Ayesha , Deverell Lil , Ormsby Gail M. , Harper C. Alex , Keeffe Jill Elizabeth 
Published: March 2018

SummaryPurposeDiabetic retinopathy (DR) is a preventable cause of vision loss. Reducing vision loss due to DR and providing access to eye care services for people with diabetes have been severely constrained by a shortage in the number of ophthalmologists. This study aimed to explore the potential for task sharing in the eye care workforce for screening, detection, and management of DR.MethodsUsing purposive sampling, 24 participants were recruited from four selected hospitals in 2 provinces in Pakistan. Face‐to‐face interviews were conducted to explore the potential for task sharing in DR management.ResultsAmongst 24 participants recruited, 22 (91.7%) including administrators (n = 3), ophthalmologists (n = 10), optometrists (n = 3), mid‐level eye care workers (n = 4), and endocrinologist (2) participated in the study. All participants indicated the need for an organised screening program for DR detection through task sharing. Participants suggested that people with diabetes can be sent directly to an optometrist for initial eye exams, rather than making them wait to be examined by an ophthalmologist. Factors favouring task sharing included the name task sharing rather than task shifting and a high demand for eye care services. Major barriers to implementation of task sharing included the lack of a trained eye care workforce in the healthcare system and the lack of coordination amongst health professionals and policy makers.ConclusionParticipants were accepting task sharing approach and believed that task sharing could improve access to eye care services for people with diabetes and better utilise the services of eye and healthcare providers.
Using the Severity of Dependence Scale to screen for DSM‐5 khat use disorder
Authors: Duresso Samson W. , Matthews Allison J. , Ferguson Stuart G. , Bruno Raimondo 
Published: March 2018

AbstractObjectiveThis study aimed to determine the efficacy of the Severity of Dependence Scale (SDS) as a screening tool for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition‐defined khat use disorder.MethodsCross‐sectional, purposive sample of past‐year khat consumers aged 16 and above were recruited from khat markets and cafes from university and general community in Adama, Ethiopia. Participants self‐completed a survey comprising current substance use disorder.ResultsThe SDS formed a unifactorial structure, consistent with the dependence construct. Almost three quarters (73%) of the sample were identified as experiencing Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition khat use disorder. The SDS demonstrated excellent discrimination (area under the curve = 0.92) and an optimal cut‐off as a score of 3 or greater, with sensitivity of 81% and specificity of 96%. This classification validly identified a group with more frequent and higher dose khat use than participants that did not screen positive.ConclusionAlthough khat is a mild stimulant, there is clear evidence that some consumers are both concerned with their use and experience problems associated with their use. Consistent with its application for other drugs, the SDS is a brief and simple screening tool that appears to validly identify individuals experiencing a khat use disorder syndrome and experiencing high rates of adverse consequences in association with use.
Association between PLA2G12A polymorphism and patients with schizophrenia in a southern Chinese Han population
Authors: Hui Li , Yin Xiao Li , Chen Jie , Zhu Hong Liang , Zhang Guang Ya , Wang Xiao Qiong , Liu Jia Hong , Zhu Cheng , Xu Dong Wu , Yu Xin , Yin Guang Zhong 
Published: March 2018

AbstractBackgroundElevated phospholipase A2 (PLA2) activity is reported to be involved in the development of schizophrenia. Further study revealed an association between PLA2 groups XIIA (PLA2G12A) polymorphism and patients with schizophrenia in a northeast Chinese Han population.ObjectiveThis study will further examine whether PLA2G12A rs3087494 polymorphism is associated with patients with schizophrenia in a southern Chinese Han population.MethodsThis polymorphism was genotyped in 438 patients with schizophrenia (diagnosed according to Diagnostic and Statistical Manual of Mental Disorders‐IV) and 876 healthy controls using a case–control design. Demographic and clinical data were collected in all subjects.ResultsThe allele and genotype frequencies of PLA2G12A rs3087494 polymorphism significantly differed between groups (both, p < .001). These differences still were significant by adjusting for sex and age. However, there was no difference in age at onset among 3 genotype groups in patients with schizophrenia by adjusting for the variables (F = 0.22, p = .80). Stepwise multivariate regression analysis showed that this polymorphism was not associated with age at onset in patients with schizophrenia (β = .008, t = .07, p = .94).ConclusionsOur results indicated that even though PLA2G12A rs3087494 polymorphism did not influence age at onset in patients with schizophrenia, it may play an important role in the susceptibility to schizophrenia in a southern Chinese Han population.
Surface moisture area during rainfall–run‐off events to understand the hydrological dynamics of a basin in a plain region
Authors: Ares María Guadalupe , Holzman Mauro , Entraigas Ilda , Varni Marcelo , Fajardo Luisa , Vercelli Natalia 
Published: March 2018

AbstractThe understanding of the hydrology of plain basins may be improved by the combined analysis of rainfall–run‐off records and remote sensed surface moisture data. Our work evaluates the surface moisture area (SMA) produced during rainfall–run‐off events in a plain watershed of the Argentine Pampas Region, and studies which hydrological variables are related to the generated SMA. The study area is located in the upper and middle basins of the Del Azul stream, characterized by the presence of small gently hilly areas surrounded by flat landscapes. Data from 9 rainfall–run‐off events were analysed. MODIS surface reflectance data were processed to calculate SMA subsequent to the peak discharge (post‐SMA), and previous to the rainfall events (prev‐SMA), to consider the antecedent wetness. Rainfall–run‐off data included total precipitation depth (P), maximum intensity of rainfall over 6 hr (I6max), surface run‐off registered between the beginning of the event and the day previous to the analysed MODIS scene (R), peak flow (Qp), and flood intensity (IF). In contrast with other works, post‐SMA showed a negative relationship with the R. Three groups of cases were identified: (a) Events of low I6max, high prev‐SMA, and low R were associated with slow and weakly channelized flow over plain areas, leading to saturated overland flow (SOF), with large SMA; (b) events of high I6max, low prev‐SMA, and medium to high R were rapidly transported along the gentle slopes of the basin, related to Hortonian overland flow (HOF) and low post‐SMA; and (c) events of medium to high I6max and prev‐SMA with medium R were related to heterogeneous input‐antecedent‐run‐off conditions combined: Local spatial conditions may have produced HOF or SOF, leading to an averaged response with medium SMA. The interactions between the geomorphology of the basin, the characteristics of the events, and the antecedent conditions may explain the obtained results. This analysis is relevant for the general knowledge of the hydrology of large plains, whose functioning studies are still in their early stages.
Deriving a water quality guideline for protection of aquatic communities exposed to triclosan in the Canadian environment
Authors: Hill Katie L , Breton Roger L , Manning Gillian E , Teed R Scott , Capdevielle Marie , Slezak Brian 
Published: March 2018

Abstract

Triclosan is an antibacterial and antifungal chemical used in a variety of consumer products, including soaps, detergents, moisturizers, and cosmetics. Aquatic ecosystems may be exposed to triclosan following the release of remaining residues in wastewater effluents and biosolids. In December 2017, Environment and Climate Change Canada (ECCC) released a federal environmental quality guideline (FEQG) report that contained a federal water quality guideline (FWQG) for triclosan. This guideline will be used as an adjunct to the risk assessment and risk management of priority chemicals identified under the Government of Canada's Chemicals Management Plan (CMP). The FWQG value for triclosan (0.47 μg/L) was derived by ECCC using a hazardous concentration for 5% of species (HC5) from a species sensitivity distribution (SSD). We recalculated the FWQG after performing an independent analysis and evaluation of the available aquatic toxicity data for triclosan and compared our results with the ECCC FWQG value. Our independent analysis of the available aquatic toxicity data entailed conducting a literature search of all available and relevant studies, evaluating the quality and reliability of all studies considered using thorough and consistent study evaluation criteria, and thereby generating a data set of high-quality toxicity values. The selected data set includes 22 species spanning 5 taxonomic groups. An SSD was developed using this data set following the ECCC approaches. The HC5 from the SSD derived based on our validated data set is 0.76 μg/L. This HC5 value is slightly greater (i.e., less sensitive) than the value presented in ECCC's final FWQG. Integr Environ Assess Manag 2018;14:437–441. © 2018 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC)

Key Points
Using a similar approach to Environment and Climate Change Canada's (ECCC's) Federal Environmental Quality Guideline (FEQG) to derive a chronic HC5 for Canadian freshwater communities, several differences from the FEQG dataset were identified in both species and endpoints selected. An HC5 of 0.76 µg/L for chronic exposure of triclosan to freshwater aquatic life was generated in the present study, which is slightly greater (i.e., less sensitive) than the HC5 calculated by ECCC in their FEQG.
SOCS1 is associated with clinical progression and acts as an oncogenic role in triple‐negative breast cancer
Authors: Qian Qian , Lv Yuetao , Li Peng 
Published: March 2018

AbstractSuppressors of cytokine signaling 1 (SOCS1) is a member of SOCS family and acts as negative regulators of cytokine signaling by direct inhibition of receptor‐associated janus kinases. The clinical significance and biological function of SOCS1 in variant tumor tissues and at variant tumor stages is still controversial. The aim of our study is to confirm the expression status of SOCS1 in triple‐negative breast cancer (TNBC) tissues and cell lines, and explore the clinical value and biological function of SOCS1 in TNBC. In microarray data sets (GDS2250 and GDS817), we observed SOCS1 was overexpressed in TNBC tissues and cell line compared with normal mammary tissues and mammary epithelial cell line, or non‐TNBC tissues and cell line. Furthermore, SOCS1 mRNA and protein overexpression were confirmed in TNBC tissues and cell lines compared with normal mammary tissues and mammary epithelial cell lines or non‐TNBC tissues and cell lines. SOCS1 protein overexpression was obviously associated with advanced clinical stage, large tumor size, more lymph node metastasis, present distant metastasis, and malign histological grade. Downregulation of SOCS1 expression suppressed TNBC cells proliferation and promoted cell apoptosis. In conclusion, SOCS1 is associated with clinical progression in TNBC patients and acts as an oncogenic role in regulating TNBC cells proliferation and apoptosis. © 2018 IUBMB Life, 70(4):320–327, 2018
Multiple Functional Variants at 13q14 Risk Locus for Osteoporosis Regulate RANKL Expression Through Long-Range Super-Enhancer
Authors: Zhu Dong-Li , Chen Xiao-Feng , Hu Wei-Xin , Dong Shan-Shan , Lu Bing-Jie , Rong Yu , Chen Yi-Xiao , Chen Hao , Thynn Hlaing Nwe , Wang Nai-Ning , Guo Yan , Yang Tie-Lin 
Published: March 2018

ABSTRACT

RANKL is a key regulator involved in bone metabolism, and a drug target for osteoporosis. The clinical diagnosis and assessment of osteoporosis are mainly based on bone mineral density (BMD). Previous powerful genomewide association studies (GWASs) have identified multiple intergenic single-nucleotide polymorphisms (SNPs) located over 100 kb upstream of RANKL and 65 kb downstream of AKAP11 at 13q14.11 for osteoporosis. Whether these SNPs exert their roles on osteoporosis through RANKL is unknown. In this study, we conducted integrative analyses combining expression quantitative trait locus (eQTL), genomic chromatin interaction (high-throughput chromosome conformation capture [Hi-C]), epigenetic annotation, and a series of functional assays. The eQTL analysis identified six potential functional SNPs (rs9533090, rs9594738, r8001611, rs9533094, rs9533095, and rs9594759) exclusively correlated with RANKL gene expression (p &lt; 0.001) at 13q14.11. Co-localization analyses suggested that eQTL signal for RANKL and BMD-GWAS signal shared the same causal variants. Hi-C analysis and functional annotation further validated that the first five osteoporosis SNPs are located in a super-enhancer region to regulate the expression of RANKL via long-range chromosomal interaction. Particularly, dual-luciferase assay showed that the region harboring rs9533090 in the super-enhancer has the strongest enhancer activity, and rs9533090 is an allele-specific regulatory SNP. Furthermore, deletion of the region harboring rs9533090 using CRISPR/Cas9 genome editing significantly reduced RANKL expression in both mRNA level and protein level. Finally, we found that the rs9533090-C robustly recruits transcription factor NFIC, which efficiently elevates the enhancer activity and increases the RANKL expression. In summary, we provided a feasible method to identify regulatory noncoding SNPs to distally regulate their target gene underlying the pathogenesis of osteoporosis by using bioinformatics data analyses and experimental validation. Our findings would be a potential and promising therapeutic target for precision medicine in osteoporosis. © 2018 American Society for Bone and Mineral Research.
Moral injury process and its psychological consequences among Israeli combat veterans
Authors: Zerach Gadi , Levi‐Belz Yossi 
Published: March 2018

AbstractObjectivesWe aim to examine the link between exposure to potentially morally injurious events (PMIEs) and posttraumatic stress disorder symptoms (PTSS). We also aim to explore the mediating roles of depressive attributions, trauma‐related guilt and shame, and self‐disgust in the relationship between PMIEs and PTSS among combat veterans.MethodA volunteers' sample of 191 Israeli combat veterans responded to self‐report questionnaires in a cross‐sectional design study.ResultsMore than one‐fifth of the sample reported experiencing PMIEs but only betrayal based experience was related to PTSS. Importantly, betrayal based experience was associated with depressive attributions which increased the level of trauma‐related distressing guilt, intrinsic shame and self‐disgust, which in turn were associated with high levels of PTSS.ConclusionsPMIEs, and especially betrayal based experiences, are related to PTSS among Israeli veterans. Depressive attributions, trauma‐related distressing guilt, intrinsic shame, and self‐disgust might serve as possible mechanisms for the links between PMIEs and PTSS.
Victims of Fukushima Daiichi nuclear power plant accident in long‐lasting disillusionment phase
Authors: Nakano Mari , Hibiya Taketoshi 
Published: March 2018

AbstractThis study describes the existence of the long‐lasting disillusionment phase for the victims after the accident at the Fukushima Daiichi Nuclear Power Plant following the Great East Japan Earthquake in March 2011. Through analyzing the mental situation of the victims, the situations were categorized into 2 groups for forced evacuees: “in the disillusionment phase” and “in the reconstruction phase,” Other 2 groups are for host Iwaki residents: “with negative feelings against evacuees” and “leading their life constructively.” The negative feeling enhances the vicious psychological cycle for the evacuees in the long‐lasting disillusionment phase and repeating emotion of survivor's guilt in the reconstruction phase. We propose that people who were getting back to a normal life while leading their life constructively should raise their voices in favor of living together with evacuees.
Gate‐to‐gate life cycle assessment of biosurfactants and bioplasticizers production via biotechnological exploitation of fats and waste oils
Authors: Kopsahelis Alexandros , Kourmentza Constantina , Zafiri Constantina , Kornaros Michael 
Published: March 2018

AbstractBACKGROUNDThis study investigated the biotransformation of fats and waste oils to glycolipid biosurfactants and bioplasticizers. The ecological performance and environmental impacts of the bioprocesses were evaluated aiming to assess their present environmental status and thus suggest future improvements using life cycle assessment (LCA) methodology.RESULTSBiosurfactants, namely rhamnolipids and sophorolipids, were obtained via fermentation. Bioplasticizers, fatty acid ethyl esters (FAEE) and monoglycerides (MAG), were developed via enzymatic catalysis with selected enzymes in mesophilic temperatures via ethanolysis and glycerolysis, respectively. The study revealed that air emissions, electricity and thermal energy requirements are the key contributors to the potential environmental impacts in the life cycle impact assessment (LCIA). More specifically, rhamnolipids production has less energetic needs compared with sophorolipids manufacturing, resulting in lower environmental impacts. The increased thermal requirements of the MAG production phase is the main contributor to their negative environmental performance, with the overall energy consumption for MAG production being 3‐fold higher than for the FAEE formation phase.CONCLUSIONSThe assessment identified that among the biosurfactant production processes, sophorolipids production resulted in 22.7% higher environmental impact compared with rhamnolipids. Similarly, FAEE production can be classified as a more environment‐ friendly process compared with MAG, resulting in 67% lower environmental impact based on the environmental indicators assessed. © 2018 Society of Chemical Industry