bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological evidence from immature stages further suggests Lignyodina being close to Tychiina (Coleoptera, Curculionidae, Curculioninae, Tychiini)
Authors: GOSIK RAFAŁ , SKUHROVEC JIŘÍ , TOŠEVSKI IVO , CALDARA ROBERTO 
Published: June 2018

The relationship between the subtribes Lignyodina and Tychiina of the Tychiini were tested on the basis of morphological characters from the immature stages. The mature larvae of Lignyodes bischoffi (Blatchley, 1916) and L. enucleator (Panzer, 1798) (Curculionidae, Curculioninae, Tychiini, Lignyodina) and the pupae of L. bischoffi are described in detail for the first time. To be sure about the correct taxonomic identification of the larvae, DNA sequences were obtained and compared for both the larvae and adults of these two species. Molecular data show that the two studied species of Lignyodes Dejean, 1835 strongly differ in mitochondrial COI and 16S rRNA. The immature stages (larva and pupa) of Lignyodes bischoffi and L. enucleator were compared with each other and with those known for other taxa representative of the tribe Tychiini and other tribes of Curculioninae. The larvae of Lignyodes bischoffi and L. enucleator differ in a few but important characters. The larvae and pupae of these two species belonging to Lignyodes s. str. are morphologically very similar to those of species in the other two subgenera of Lignyodes, Neotylopterus Clark, Whitehead & Warner, 1977 and Chionanthobius Pierce, 1912. On the basis of the detailed morphology of larvae and pupae, we agree that Lignyodes belong to Tychiini, sharing more features with species of this tribe than with those of other tribes of Curculioninae. New bionomic data concerning larval and pupal development and adult emergence are reported for both described species and confirm close relationships between the subtribes Lignyodina and Tychiina. On the other hand, strong molecular differences, corroborated by some relevant larval differences, between L. enucleator and L. bischoffi open up the issue whether Palaearctic and Nearctic species presently included in Lignyodes s. str. actually belong to the same subgenus.
The Atmospheric Moisture Residence Time and Reference Time for Moisture Tracking over China
Authors: Wang Ning , Zeng Xin-Min , Zheng Yiqun , Zhu Jian , Jiang Shanhu 
Published: June 2018

Abstract
This paper studies the atmospheric moisture residence times over China for the period 1980–2009 using the dynamic recycling model (DRM). We define both the residence times for atmospheric moisture of precipitation (backward tracking) and evaporation (forward tracking) and show that each has significant spatial and seasonal variations. The area-averaged precipitation-moisture residence time is approximately 8.3 days, while the evaporation residence time is approximately 6.3 days. In addition, we investigate the concept of “tracking time” or time selected for moisture tracking in numerical source–sink studies. The area-averaged backward and forward tracking times at the 90% threshold (i.e., when 90% of initial moisture is attributed for tracking) are approximately 22 and 15 days, respectively. Finally, we theoretically deduced the explicit expressions for residence and tracking times for idealized cases and found the analytical proportional relationship between these times. In this way, the analytical link between residence time and e-folding time was reestablished. This proportional relationship was further verified against the DRM-derived values. In the DRM results, the proportional relation generally fluctuates along the trajectory, which leads to the differences between the theoretical and the DRM-derived values. These results can enhance our understanding of water cycling, and they are likely to help choose tracking times in relevant studies.
Diffusive Convection under Rapidly Varying Conditions
Authors: Umlauf Lars , Holtermann Peter L. , Gillner Christiane A. , Prien Ralf D. , Merckelbach Lucas , Carpenter Jeffrey R. 
Published: June 2018

AbstractIn most observations of diffusive convection in the ocean and in lakes, the characteristic diffusive staircases evolve over long time scales under quasi-stationary background conditions. In the Baltic Sea, however, diffusive staircases develop inside the flanks of intermittent intrusions that induce strong inverse temperature gradients over a vertical range of a few meters, varying on time scales of hours to days. Here, results are discussed from an extensive field campaign conducted in summer 2016 in the southern Baltic Sea, including temperature microstructure data from ocean gliders and an autonomous profiling platform. We find conditions favorable for diffusive instability in the vicinity of warm and cold intrusions with density ratios as small as Rρ = 1.3. The staircases evolving under these conditions are characterized by a small number of steps (typically 1–4) with order 0.1–1-m thickness, temperature differences exceeding 1 K across individual diffusive interfaces, and exceptionally large diffusive heat fluxes of order 10 W m−2. The standard heat flux parameterization of Kelley agrees within a factor of 2 with the directly observed interfacial heat fluxes, except for large fluxes at low Rρ, which are strongly overestimated. The glider surveys reveal a surprisingly small lateral coherency of order 100 m of the staircase patterns, and a spreading of the diffusively unstable intrusions across isopycnals.
Severely impaired terminal erythroid differentiation as an independent prognostic marker in myelodysplastic syndromes
Authors: Ali Abdullah Mahmood , Huang Yumin , Pinheiro Ronald Feitosa , Xue Fumin , Hu Jingping , Iverson Nicholas , Hoehn Daniela , Coutinho Diego , Kayani Jehanzeb , Chernak Brian , Lane Joseph , Hillyer Christopher , Galili Naomi , Jurcic Joseph , Mohandas Narla , An Xiuli , Raza Azra 
Published: June 2018

Key PointsTED is defective in patients with MDS. TED is an independent prognostic factor for survival in MDS.
Valproate in combination with rituximab and CHOP as first-line therapy in diffuse large B-cell lymphoma (VALFRID)
Authors: Drott Kristina , Hagberg Hans , Papworth Karin , Relander Thomas , Jerkeman Mats 
Published: June 2018

Key Points
This trial evaluates addition of the histone deacetylase inhibitor valproate to standard R-CHOP therapy in DLBCL. Addition of valproate to R-CHOP is a promising strategy in DLBCL, but auditory side effects warrant monitoring.
Spatio-temporal neural stem cell behavior leads to both perfect and imperfect structural brain regeneration in adult newts
Authors: Urata Yuko , Yamashita Wataru , Inoue Takeshi , Agata Kiyokazu 
Published: June 2018

ABSTRACT
Adult newts can regenerate large parts of their brain from adult neural stem cells (NSCs), but how adult NSCs reorganize brain structures during regeneration remains unclear. In development, elaborate brain structures are produced under broadly coordinated regulations of embryonic NSCs in the neural tube, whereas brain regeneration entails exquisite control of the re-establishment of certain brain parts, suggesting that a yet-unknown mechanism directs NSCs upon partial brain excision. Here we report that upon excision of a quarter of the adult newt (Pleurodeles waltl) mesencephalon, active participation of local NSCs around specific brain subregions’ boundaries leads to some imperfect and some perfect brain regeneration along an individual's rostrocaudal axis. Regeneration phenotypes depend on how wound closing occurs using local NSCs, and perfect regeneration replicates development-like processes, but takes more than 1 year. Our findings indicate that newt brain regeneration is supported by modularity of boundary-domain NSCs with self-organizing ability in neighboring fields.
This article has an associated First Person interview with the first author of the paper.
Quantitative magnetic resonance imaging and radiogenomic biomarkers for glioma characterisation: a systematic review
Authors: Seow Pohchoo , Wong Jeannie Hsiu Ding , Ahmad-Annuar Azlina , Mahajan Abhishek , Abdullah Nor Aniza , Ramli Norlisah 
Published: June 2018

Objective:
The diversity of tumour characteristics among glioma patients, even within same tumour grade, is a big challenge for disease outcome prediction. A possible approach for improved radiological imaging could come from combining information obtained at the molecular level. This review assembles recent evidence highlighting the value of using radiogenomic biomarkers to infer the underlying biology of gliomas and its correlation with imaging features.

Methods:
A literature search was done for articles published between 2002 and 2017 on Medline electronic databases. Of 249 titles identified, 38 fulfilled the inclusion criteria, with 14 articles related to quantifiable imaging parameters (heterogeneity, vascularity, diffusion, cell density, infiltrations, perfusion, and metabolite changes) and 24 articles relevant to molecular biomarkers linked to imaging.

Results:
Genes found to correlate with various imaging phenotypes were EGFR, MGMT, IDH1, VEGF, PDGF, TP53, and Ki-67. EGFR is the most studied gene related to imaging characteristics in the studies reviewed (41.7%), followed by MGMT (20.8%) and IDH1 (16.7%). A summary of the relationship amongst glioma morphology, gene expressions, imaging characteristics, prognosis and therapeutic response are presented.

Conclusion:
The use of radiogenomics can provide insights to understanding tumour biology and the underlying molecular pathways. Certain MRI characteristics that show strong correlations with EGFR, MGMT and IDH1 could be used as imaging biomarkers. Knowing the pathways involved in tumour progression and their associated imaging patterns may assist in diagnosis, prognosis and treatment management, while facilitating personalised medicine.

Advances in knowledge:
Radiogenomics can offer clinicians better insight into diagnosis, prognosis, and prediction of therapeutic responses of glioma.
Amar, escrever, Saber de si: a questão da autorreflexividade nos diários das femmes de lettres Aline De Lens (1881–1925) e Catherine Pozzi (1882-1934).
Authors: PINTO ALINE MAGALHÃES 
Published: June 2018

Resumo: Atualmente, a escrita autorreferencial ou “escrita de si” (Self-writing) vêm atraindo a atenção de muitos pesquisadores, interessados em perscrutar na intimidade e na memória individual os processos sociais, culturais, políticos e discursivos que movimentam a conformação do indivíduo moderno e a historicidade de sua relação com a sociedade. Neste panorama mais amplo, e cada vez mais explorado, nossa proposta de pesquisa foca-se, de maneira comparativa-contrastativa, em dois registros textuais deveras singulares: os escritos autobiográficos de Catherine Pozzi e Aline De Lens. Nossa hipótese será: em um escrito autorreferencial ou escrita de si, a relação entre o eu-autor e o eu que se deixa retratar não poderia ser regulada por um valor de verdade que se orienta pela adequação ao que de fato ocorreu i.e. valor sob o qual se sustenta a especificidade do discurso historiográfico. Tampouco será satisfatório assumir a fatalidade de um eu ficcional que se expressa numa “literatura”. Nesse sentido, o discurso autorreferencial aparece como uma forma que flutua entre o pragmático e o fictício. Dirigindo-se inicialmente para o registro do que foi libera-se dessa amarra transformando-se num espelho que, ao exigir sinceridade para obter autenticidade - tal qual o autorretrato na pintura –, abre um abismo reflexivo, característico da Alta Modernidade. Palavras-chave: Discurso autorreferencial; subjetividade; reflexividade; diários.
An evaluation of how trainee nursing associates (TNAs) balance being a ‘worker’ and a ‘learner’ in clinical practice: an early experience study. Part 1/2
Authors: Coghill Elaine 
Published: June 2018

In December 2015, the Government announced plans to introduce a ‘nursing associate’ role to bridge the gap between healthcare support workers and registered nurses ( Gummer, 2015 ). The role, according to the Department of Health and Social Care (DHSC), will be to deliver hands-on care that will allow registered nurses to spend increasing time on clinical duties and take more of a lead in decisions about patient care ( Merrifield, 2015 ). In July 2016, Health Education England said that this role was to be introduced in a two-phase process, with 1000 trainee nursing associates (TNAs) recruited in December 2016 to start in January 2017 and a second pilot phase with a further 1000 TNAs recruited to start in April 2017. In January 2017, the Nursing and Midwifery Council (NMC) subsequently agreed to the DHSC's request to become the regulator for nursing associates and has been consulting on various aspects of its responsibilities since. The aim of the author's project was to undertake an early-experience evaluation of TNA roles across the northeast of England, focusing on how the TNAs balance being a ‘worker’ and a ‘learner’ in clinical practice, in order to inform future cohorts. The results found give rise to a number of areas for discussion, including: role clarity; placement models; mentorship and protected learning time. These are helping to inform the third phase of TNA recruitment in 2018 in the northeast of England and will be fed back into the national evaluation.
Assessment of Digital PCR as a Primary Reference Measurement Procedure to Support Advances in Precision Medicine
Authors: Whale Alexandra S , Jones Gerwyn M , Pavšič Jernej , Dreo Tanja , Redshaw Nicholas , Akyürek Sema , Akgöz Müslüm , Divieto Carla , Sassi Maria Paola , He Hua-Jun , Cole Kenneth D , Bae Young-Kyung , Park Sang-Ryoul , Deprez Liesbet , Corbisier Philippe , Garrigou Sonia , Taly Valérie , Larios Raquel , Cowen Simon , O'Sullivan Denise M , Bushell Claire A , Goenaga-Infante Heidi , Foy Carole A , Woolford Alison J , Parkes Helen , Huggett Jim F , Devonshire Alison S 
Published: June 2018

Abstract

BACKGROUND
Genetic testing of tumor tissue and circulating cell-free DNA for somatic variants guides patient treatment of many cancers. Such measurements will be fundamental in the future support of precision medicine. However, there are currently no primary reference measurement procedures available for nucleic acid quantification that would support translation of tests for circulating tumor DNA into routine use.

METHODS
We assessed the accuracy of digital PCR (dPCR) for copy number quantification of a frequently occurring single-nucleotide variant in colorectal cancer (KRAS c.35G&gt;A, p.Gly12Asp, from hereon termed G12D) by evaluating potential sources of uncertainty that influence dPCR measurement.

RESULTS
Concentration values for samples of KRAS G12D and wild-type plasmid templates varied by &lt;1.2-fold when measured using 5 different assays with varying detection chemistry (hydrolysis, scorpion probes, and intercalating dyes) and &lt;1.3-fold with 4 commercial dPCR platforms. Measurement trueness of a selected dPCR assay and platform was validated by comparison with an orthogonal method (inductively coupled plasma mass spectrometry). The candidate dPCR reference measurement procedure showed linear quantification over a wide range of copies per reaction and high repeatability and interlaboratory reproducibility (CV, 2%–8% and 5%–10%, respectively).

CONCLUSIONS
This work validates dPCR as an SI-traceable reference measurement procedure based on enumeration and demonstrates how it can be applied for assignment of copy number concentration and fractional abundance values to DNA reference materials in an aqueous solution. High-accuracy measurements using dPCR will support the implementation and traceable standardization of molecular diagnostic procedures needed for advancements in precision medicine.
There’ll always be an England – Butlins, Brexit and the heterotopic body
Authors: O’Thomas Mark 
Published: June 2018

Abstract
This article addresses the role of entertainment and performance in the holiday camp today as a way of understanding its interface with contemporary concerns around the impact of mass immigration and consequent emerging nationalisms. Focusing on the British Butlins holiday camp, which still maintains its original base in the English north-east coastal town of Skegness, the article builds on the work of earlier studies of leisure camps (and camps in general) in locating the function of entertainment as a key engine in driving forward a sense of ‘England’ that is at the same time nostalgic and isolationist. Within the context of the UK referendum result on 15 June 2016 to exit the European Union, alongside recent concerns of new manifestations of racism and the marginalization of foreign nationals working in the United Kingdom, the article addresses the paradox of the use of a mode that has the capacity to engender empathy as a way of objectifying the Other and consolidating a notion of a single sovereign state. Ultimately, while acknowledging the contribution made by contemporary philosophers such as Giorgio Agamben to the field, the article revisits and finds Foucault’s notion of heterotopias as a more dextrous way of conceiving of the ways in which entertainments are planned, produced and performed at British leisure camps today.
Plant-Based Solutions to Global Livestock Anthelmintic Resistance
Authors: French Katherine E. 
Published: June 2018

Anthelmintic resistance in livestock is increasing globally. Livestock intestinal parasites now develop resistance to synthetic anthelmintics within 2–10 years, collectively costing billions of dollars annually in lost revenue around the world. Over-reliance on commercial drugs and dips and changes in livestock management practices are key drivers of this trend. To date, current research has focused on identifying new anthelmintics from bacterial and fungal sources or even synthesizing new drugs that target parasite metabolism or reproduction. Plant-derived anthelmintics are a promising alternative, yet to date major research funders and scientists have overlooked this option. Until the mid-20th century, rural communities relied on plant-based methods of controlling livestock parasites. These methods include feeding livestock specific medicinal plants and trees, grazing livestock on herbal leys, and changing where livestock grazed based on ecological factors (e.g., flooding) that increased parasite burdens. Many historic texts and ethnological accounts record the ethnobotanical knowledge of rural communities and the plants they used to control livestock intestinal parasites. Some traditions persist today yet the farmers, graziers, and shepherds who hold this knowledge are rapidly disappearing and with them perhaps a potential long-term solution to anthelmintic resistance. This short perspective piece will cover recent research using ethnobotanical data as a means to identifying potential new anthelmintics; the morphological, physiological, and metabolic effect of plant secondary metabolites on parasites; and an overview of “best practices” which can reduce bias in assessments of plant bioactivity and increase reproducibility of test results. This will hopefully bring recent advances in ethnobiology, chemistry, and ecology to new audiences, and, potentially, spark new interest in using medicinal plants to improve livestock health.
Hypertriglyceridemia thalassemia syndrome
Authors: Jain Mili , Ali Wahid , Singh Brijendra Bahadur , Verma Nishant , Kumar Ashutosh 
Published: June 2018

Abstract

Background
Hypertriglyceridemia thalassemia syndrome is a rare entity with an unknown pathogenetic link.

Case presentation
We report a case of an 8-month-old female with thalassemia major and increased triglyceride (TG) levels. The clinical features were as in classical thalassemia except for a white discoloration of the plasma. After exclusion of familial triglyceridemia and secondary causes (hypothyroidism, nephrotic syndrome, drugs etc.), a diagnosis of hypertriglyceridemia thalassemia syndrome was made.

Conclusions
The high levels of TG in these patients are associated with oxidative stress and higher risk of acute pancreatitis and coronary diseases. An early recognition is thus essential. In our patient, the levels reduced after a transfusion therapy similar to previous reports.
The rise of person agreement in East Lezgic: Assessing the role of frequency
Authors: Bogomolova Natalia 
Published: June 2018

AbstractGrammaticalization is often considered to reflect frequent co-occurrence of certain elements in certain positions. This paper tests the frequency-based account of the grammaticalization of person agreement, comparing the grammaticalization of person agreement in Tabasaran, a Lezgic language, with the syntax of free pronouns in closely related Agul. Our assumption is that the situation in Agul, where person marking is not grammaticalized, approximately reflects a diachronic stage prior to the grammaticalization of person marking in closely related Tabasaran. We find little evidence in support of a frequency-based approach, at least when frequency is treated in terms of global frequencies. We do, however, identify a highly frequent verb that already in Agul appears to regularly associate with the pattern that has generalized to become person agreement in Tabasaran. We suggest specific information structural configurations associated with this verb, which have provided the impetus for the development. More generally, we show that while global measures of frequency may not yield the correct predictions, investigating the syntactic constructions associated with individual lexical items may be more revealing, and provide a more realistic model for reconstructing the paths of syntactic change involving the generalization of existing and quite local patterns.
Therapeutic potential of JAK/STAT pathway modulation in mood disorders
Authors: Shariq Aisha S. , Brietzke Elisa , Rosenblat Joshua D. , Pan Zihang , Rong Carola , Ragguett Renee-Marie , Park Caroline , McIntyre Roger S. 
Published: June 2018

Abstract
Convergent evidence demonstrates that immune dysfunction (e.g. chronic low-grade inflammatory activation) plays an important role in the development and progression of mood disorders. The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway is a pleiotropic cellular cascade that transduces numerous signals, including signals from the release of cytokines and growth factors. The JAK/STAT signaling pathway is involved in mediating several functions of the central nervous system, including neurogenesis, synaptic plasticity, gliogenesis, and microglial activation, all of which have been implicated in the pathophysiology of mood disorders. In addition, the antidepressant actions of current treatments have been shown to be mediated by JAK/STAT-dependent mechanisms. To date, two JAK inhibitors (JAKinibs) have been approved by the U.S. Food and Drug Administration and are primarily indicated for the treatment of inflammatory conditions such as rheumatoid arthritis. Indirect evidence from studies in populations with inflammatory conditions indicates that JAKinibs significantly improve measures of mood and quality of life. There is also direct evidence from studies in populations with depressive disorders, suggesting that JAK/STAT pathways may be involved in the pathophysiology of depression and that the inhibition of specific JAK/STAT pathways (i.e. via JAKinibs) may be a promising novel treatment for depressive disorders.