bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features and visual outcomes of 111 patients with new-onset acute Vogt-Koyanagi-Harada disease treated with pulse intravenous corticosteroids
Authors: Nakayama Makiko , Keino Hiroshi , Watanabe Takayo , Okada Annabelle A 
Published: April 2018

PurposeTo describe the clinical features, treatment and visual outcomes of Japanese patients with new-onset acute Vogt-Koyanagi-Harada (VKH) disease.MethodsClinical records of 111 patients who presented between 1999 and 2015 to the Ocular Inflammation Service of the Kyorin Eye Center, Tokyo, were reviewed.ResultsOf the 111 patients (68 women, 43 men), 16 had complete, 90 had incomplete and 5 had probable VKH disease. The median follow-up period was 36 months (4–175 months). The mean age at presentation was 41 years (19–74 years). Serous retinal detachment (202 eyes) and optic disc hyperaemia (89 eyes) were observed at presentation. Of the patients tested, 45/48 (93.8%) were human leucocyte antigen-DR4 positive and 63/77 (81.8%) had cerebrospinal fluid pleocytosis. Initial corticosteroid treatment consisted of pulse intravenous therapy in all patients. Sunset glow fundus was observed in 49.5% of eyes, and anterior and/or posterior segment recurrence of inflammation was observed in 25 patients (22.5%). Treatment was transitioned to cyclosporine in 17 patients (15.3%) for steroid sparing (6 patients) or recurrent inflammation (11 patients), with good subsequent control. Ocular complications were observed in 47 of 222 eyes (21.2%) (mostly cataract), and systemic complications were observed in 8.1% of patients (mostly hypertension and diabetes mellitus). Ninety-three percent of eyes (167 of 178 eyes) had a visual acuity of ≥1.0 at 1 year after presentation.ConclusionsAn aggressive corticosteroid treatment strategy in a large number of patients with new-onset acute VKH disease, with transitioning to cyclosporine in selected cases, resulted in excellent visual outcomes and low rates of recurrence.
Doctors on the move: a European case study on the key characteristics of national recertification systems
Authors: Sehlbach Carolin , Govaerts Marjan J , Mitchell Sharon , Rohde Gernot G U , Smeenk Frank W J M , Driessen Erik W 
Published: April 2018

ObjectivesWith increased cross-border movement, ensuring safe and high-quality healthcare has gained primacy. The purpose of recertification is to ensure quality of care through periodically attesting doctors’ professional proficiency in their field. Professional migration and facilitated cross-border recognition of qualifications, however, make us question the fitness of national policies for safeguarding patient care and the international accountability of doctors.Design and settingWe performed document analyses and conducted 19 semistructured interviews to identify and describe key characteristics and effective components of 10 different European recertification systems, each representing one case (collective case study). We subsequently compared these systems to explore similarities and differences in terms of assessment criteria used to determine process quality.ResultsGreat variety existed between countries in terms and assessment formats used, targeting cognition, competence and performance (Miller’s assessment pyramid). Recertification procedures and requirements also varied significantly, ranging from voluntary participation in professional development modules to the mandatory collection of multiple performance data in a competency-based portfolio. Knowledge assessment was fundamental to recertification in most countries. Another difference concerned the stakeholders involved in the recertification process: while some systems exclusively relied on doctors’ self-assessment, others involved multiple stakeholders but rarely included patients in assessment of doctors’ professional competence. Differences between systems partly reflected different goals and primary purposes of recertification.ConclusionRecertification systems differ substantially internationally with regard to the criteria they apply to assess doctors’ competence, their aims, requirements, assessment formats and patient involvement. In the light of professional mobility and associated demands for accountability, we recommend that competence assessment includes patients’ perspectives, and recertification practices be shared internationally to enhance transparency. This can help facilitate cross-border movement, while guaranteeing high-quality patient care.
Development of sustainable community paramedicine programmes: a case study in Pennsylvania
Authors: Huang Yuan-Han , Ma Linlin , Sabljak Luke A , Puhala Zachary A 
Published: April 2018

BackgroundCommunity paramedicine (CP) models have been applied across rural and urban communities in support of healthcare delivery systems for nearly two decades. However, there is still insufficient information regarding the development of sustainable CP programmes. This study explores the strategies used by active CP programmes and investigates their operational statuses, community demographics, financial models and challenges for programme development.MethodsA series of interviews was conducted with four CP programmes in Pennsylvania, USA, which are affiliated with a local government, a health system, an ambulance service and an emergency medical service, respectively. Each CP programme uses its own model with unique goals, as well as providing corresponding services/care based on the demands from their communities.ResultsThree CP programmes in the study were mainly aimed at reducing healthcare resource utilisation (ie, reduce readmissions or ED utilisation), but one of the programmes developed a sustainable model aiding newborn care in the community. Establishing a solid reimbursement mechanism and working closely with collaborators are two major strategies for developing sustainable CP programmes. Complete data collection and a programme evaluation process will also be important to demonstrate the value of its CP models to potential collaborators and policy-makers. However, the cost-effectiveness of a CP model is still not easy to identify due to the separate programmes being developed without uniform goals.ConclusionThe challenges and solutions from the four programmes under study can provide a road map for the development of CP programmes for other communities.
Causes of death in a contemporary adult congenital heart disease cohort
Authors: Yu Christopher , Moore Benjamin M , Kotchetkova Irina , Cordina Rachael L , Celermajer David S 
Published: April 2018

ObjectiveThe life expectancy of patients with congenital heart disease (CHD) has significantly improved with advances in their paediatric medical care. Mortality patterns are changing as a result. Our study aims to describe survival and causes of death in a contemporary cohort of adult patients with CHD.MethodsWe reviewed 3068 patients in our adult CHD database (age ≥16 years, seen at least once in our centre between 2000 and 2015), and documented the number and causes of death, via Australia’s National Death Index. Survival and mortality patterns were analysed by complexity of CHD and by underlying congenital diagnosis.ResultsOur cohort comprised 3068 adult patients (53% male). The distribution of patients (per the Bethesda classification) was 47% simple, 34% moderate and 18% complex (1% not classifiable). Over a median follow-up of 6.2 years (IQR 3.5–10.4), 341 patients (11%) died with an incidence of 0.4 deaths/100 patient years (py). Survival was significantly worse with increasing complexity of CHD (p<0.001); mortality rate in the simple group was 0.3 deaths/100 py with a median age of death 70 years, and in the complex group was 1.0 death/100 py with a median age of death 34 years. Overall, non-cardiac causes of death outnumbered cardiac causes, at 54% and 46%, respectively. The leading single cause of death was heart failure (17%), followed by malignancy (13%). Simple adult CHD patients mostly died due to non-cardiac causes such as malignancy. Perioperative mortality only accounted for 5% of deaths.ConclusionsPremature death is common in adults with CHD. Although heart failure remains the most common cause of death, in the contemporary era in a specialist CHD centre, non-cardiac related deaths outnumber cardiac deaths, particularly in those with simple CHD lesions.
Causal associations between body mass index and mental health: a Mendelian randomisation study
Authors: van den Broek Nina , Treur Jorien L , Larsen Junilla K , Verhagen Maaike , Verweij Karin J H , Vink Jacqueline M 
Published: April 2018

BackgroundBody mass index (BMI) is correlated negatively with subjective well-being and positively with depressive symptoms. Whether these associations reflect causal effects is unclear.MethodsWe examined bidirectional, causal effects between BMI and mental health with Mendelian randomisation using summary-level data from published genome-wide association studies (BMI: n=339 224; subjective well-being: n=204 966; depressive symptoms: n=161 460). Genetic variants robustly related to the exposure variable acted as instrumental variable to estimate causal effects. We combined estimates of individual genetic variants with inverse-variance weighted meta-analysis, weighted median regression and MR-Egger regression.ResultsThere was evidence for a causal, increasing effect of BMI on depressive symptoms and suggestive evidence for a decreasing effect of BMI on subjective well-being. We found no evidence for causality in the other direction.ConclusionThis study provides support for a higher BMI causing poorer mental health. Further research should corroborate these findings and explore mechanisms underlying this potential causality.
Split hand muscle echo intensity index as a reliable imaging marker for differential diagnosis of amyotrophic lateral sclerosis
Authors: Seok Hung Youl , Park Jinseok , Kim Yoo Hwan , Oh Ki-Wook , Kim Seung Hyun , Kim Byung-Jo 
Published: April 2018

ObjectiveThe objective of this study was to investigate the usefulness of muscle ultrasound in evaluating dissociated small hand muscle atrophy, termed ‘split hand’, and its feasibility in the diagnosis of amyotrophic lateral sclerosis (ALS).MethodsForty-four patients with ALS, 18 normal subjects and 9 patients with other neuromuscular disorders were included in this study. The hand muscles were divided into three regions, the median-innervated lateral hand muscle group (ML), the ulnar-innervated lateral hand muscle (UL) and the ulnar-innervated medial hand muscle (UM), and the muscle echo intensity (EI) and compound muscle action potential (CMAP) were measured. We calculated the split hand index (SHI) using muscle EI (SHImEI) and CMAP (SHICMAP) for comparison among groups. The SHI was derived by dividing muscle EI (or CMAP) measured at the ML and UL by that measured at the UM.ResultsThe SHImEI was significantly higher in patients with ALS (51.7±28.3) than in normal controls (29.7±9.9) and disease controls with other neuromuscular disorders (36.5±7.3; P<0.001), particularly in upper limb-onset ALS (66.5±34.0; P<0.001). Receiver operating characteristic curve analysis indicated that the SHImEI had significantly better diagnostic accuracy than the SHICMAP.ConclusionsThe SHImEI was more sensitive in evaluating dissociated small hand muscle atrophy compared with the SHICMAP and may be a reliable diagnostic marker for differentiating ALS from other neuromuscular disorders and healthy controls.
‘We have a rich heritage and, we believe, a bright future’: how transnational tobacco companies are using Twitter to oppose policy and shape their public identity
Authors: Watts Christina , Hefler Marita , Freeman Becky 
Published: April 2018

Background
The tobacco industry has a long history of opposing tobacco control policy and promoting socially responsible business practices. With the rise of social media platforms, like Twitter, the tobacco industry is enabled to readily and easily communicate these messages.

Methods
All tweets published by the primary corporate Twitter accounts of British American Tobacco (BAT), Imperial Brands PLC (Imperial), Philip Morris International (PMI) and Japan Tobacco International (JTI) were downloaded in May 2017 and manually coded under 30 topic categories.

Results
A total of 3301 tweets across the four accounts were analysed. Overall, the most prominent categories of tweets were topics that opposed or critiqued tobacco control policies (36.3% of BAT’s tweets, 35.1% of Imperial’s tweets, 34.0% of JTI’s tweets and 9.6% of PMI’s tweets). All companies consistently tweeted to promote an image of being socially and environmentally responsible. Tweets of this nature comprised 29.1% of PMI’s tweets, 20.9% of JTI’s tweets, 18.4% of Imperial’s tweets and 18.4% of BAT’s tweets. BAT, Imperial, JTI and PMI also frequently used Twitter to advertise career opportunities, highlight employee benefits, promote positive working environments and bring attention to awards and certifications that the company had received (11.6%, 11.1%, 19.3% and 45.7% of the total tweets published by each account, respectively).

Conclusions
Transnational tobacco companies are using Twitter to oppose tobacco control policy and shape their public identity by promoting corporate social responsibility initiatives in violation of WHO Framework Convention on Tobacco Control. Regulation of the tobacco industry’s global online activities is required.
Lower Triassic reservoir development in the northern Dutch offshore
Authors: Kortekaas M. , Böker U. , van der Kooij C. , Jaarsma B. 
Published: April 2018

Abstract
Sandstones of the Main Buntsandstein Subgroup represent a key element of the well-established Lower Triassic hydrocarbon play in the southern North Sea area. Mixed aeolian and fluvial sediments of the Lower Volpriehausen and Detfurth Sandstone members form the main reservoir rock, sealed by the Solling Claystone and/or Röt Salt. It is generally perceived that reservoir presence and quality decrease towards the north and that the prospectivity of the Main Buntsandstein play in the northern Dutch offshore is therefore limited. Lack of access to hydrocarbon charge from the underlying Carboniferous sediments as a result of the thick Zechstein salt is often identified as an additional risk for this play. Consequently, only a few wells have tested Triassic reservoir and therefore this part of the basin remains under-explored. Seismic interpretation of the Lower Volpriehausen Sandstone Member was conducted and several untested Triassic structures are identified. A comprehensive, regional well analysis suggests the presence of reservoir sands north of the main fairway. The lithologic character and stratigraphic extent of these northern Triassic deposits may suggest an alternative reservoir provenance in the marginal Step Graben system. Fluvial sands with (local) northern provenance may have been preserved in the NW area of the Step Graben system, as seismic interpretation indicates the development of a local depocentre during the Early Triassic. These insights help to improve the chance of finding Lower Buntsandstein reservoir rocks in the northern Dutch offshore.
The impact of heterogeneity on waterflood developments in clastic inner shelf reservoirs: an example from the Holland Greensand Member, Rotterdam Field, The Netherlands
Authors: Porter Richard J. , Rojas Alberto Muñoz , Schlüter Malte 
Published: April 2018

Abstract
A geological understanding of the way fluids flow through a reservoir is crucial when considering waterflood developments in heterogeneous reservoirs. Recent integrated production geoscience and reservoir engineering studies on the Holland Greensand oil reservoir (Aptian) of the Rotterdam Field in the West Netherlands Basin, are used to illustrate the geological controls on fluid flow through rocks deposited in a clastic inner shelf depositional setting. An integrated understanding of the subsurface has been gained through core, log and production data analysis. Analogous Early Cretaceous Upper Greensand Formation coastal exposures in SW England have been used to gauge the scale of lateral and vertical heterogeneity, and its impact on hydrocarbon and water flow paths. Argillaceous sandstones deposited at the distal margins of a subtidal sand-sheet provide internal reservoir baffles, while fluids are believed to preferentially follow flow paths through associated laterally extensive tempestites. Cemented layers observable in wells are interpreted to be laterally restricted and are not considered as major baffles. These observations have been used to steer static reservoir model construction and subsequent simulation. Results from field testing by production logging tool analysis support the geological concepts developed and the modelling approach used. This work has important implications for defining the approach for future reservoir management and redevelopment in the Rotterdam Field, in particular the well type and configuration and completion strategies post-reservoir flooding. The application of methodologies employed in this study is recommended for similar waterflood developments.
Influence of inherited Indian basement faults on the evolution of the Himalayan Orogen
Authors: Godin Laurent , Soucy La Roche Renaud , Waffle Lindsay , Harris Lyal B. 
Published: April 2018

Abstract
Indian basement faults, which bound three orogen-perpendicular palaeotopographic ridges of Precambrian Indian basement south of the Himalaya, extend to the base of the Indian lithosphere and to the northern extent of the Indian lithosphere underneath Tibet. In the eastern Himalaya, the active orogen-perpendicular Yadong–Gulu graben is aligned with an earthquake-generating strike-slip fault in the high Himalaya. We argue that the graben results from crustal necking during reactivation of the underplated basement fault. In the central Himalaya, along-strike diachronous deformation and metamorphism within the Himalayan metamorphic core, as well as lateral ramps in the foreland thrust belt, spatially correspond to the Lucknow and Pokhara lineaments that bound the subsurface Faizabad Ridge in the Indian basement. Analogue centrifuge modelling confirms that offset along such deep-seated basement faults can affect the location, orientation and type of structures developed at various stages of orogenesis and suggests that it is mechanically feasible for strain to propagate through a melt-weakened mid-crust. We suggest that inherited Indian basement faults affect the ramp-flat geometry of the basal Main Himalayan Thrust, partition the Himalayan range into distinct zones, localize east–west extension resulting in the Tibetan graben and, ultimately, contribute to lateral variability in tectonic evolution along the orogen's strike.
A Gallium-67/68–Labeled Antibody Fragment for Immuno-SPECT/PET Shows Low Renal Radioactivity Without Loss of Tumor Uptake
Authors: Uehara Tomoya , Yokoyama Miki , Suzuki Hiroyuki , Hanaoka Hirofumi , Arano Yasushi 
Published: April 2018

Abstract
Purpose: This study was undertaken to evaluate the renal radioactivity levels of a newly designed 67Ga-labeled antibody fragment with a linkage cleaved by enzymes present on the brush border membrane (BBM) lining the lumen of the renal tubule.
Experimental Design: 67Ga-labeled S-2-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (SCN-Bn-NOTA) was conjugated with an antibody Fab fragment through a Met-Val-Lys linkage (67Ga-NOTA-MVK-Fab) considering that a Met-Val sequence is a substrate of enzymes on the renal BBM and 67Ga-NOTA-Met is excreted from the kidney into the urine. The enzymatic recognition of the linkage was evaluated with a low-molecular-weight 67Ga-NOTA-Met-Val-Lys derivative. Biodistribution of radioactivity after injection of 67Ga-NOTA-MVK-Fab into mice was compared with 67Ga-NOTA-conjugated Fab fragments through a Met-Ile linkage that liberates 67Ga-NOTA-Met (67Ga-NOTA-MI-Fab) or a conventional thiourea linkage (67Ga-NOTA-Fab).
Results: The MVK linkage remained stable in plasma and was recognized by enzymes on renal BBM to liberate 67Ga-NOTA-Met. When injected into mice, all three 67Ga-labeled Fab exhibited similar blood clearance rates and tumor accumulation. Significant differences were observed in the kidney where 67Ga-NOTA-MVK-Fab registered the lowest renal radioactivity levels from early postinjection time (P &lt; 0.05), followed by 67Ga-NOTA-MI-Fab, which was well reflected in the SPECT/CT images.
Conclusions: These findings indicated that our proposal of liberating a radiolabeled compound to urinary excretion from antibody fragments at the renal BBM to reduce the renal radioactivity levels was applicable to 67/68Ga-labeled antibody fragments. Because antibody fragments and constructs share similar metabolic fates in the kidney, the present labeling procedure would also apply to a variety of antibody fragments and constructs of interest. Clin Cancer Res; 24(14); 3309–16. ©2018 AACR.
Targeting Galectin-1 Impairs Castration-Resistant Prostate Cancer Progression and Invasion
Authors: Shih Tsung-Chieh , Liu Ruiwu , Wu Chun-Te , Li Xiaocen , Xiao Wenwu , Deng Xiaojun , Kiss Sophie , Wang Ting , Chen Xiao-Jia , Carney Randy , Kung Hsing-Jien , Duan Yong , Ghosh Paramita M. , Lam Kit S. 
Published: April 2018

AbstractPurpose: The majority of patients with prostate cancer who are treated with androgen-deprivation therapy (ADT) will eventually develop fatal metastatic castration-resistant prostate cancer (mCRPC). Currently, there are no effective durable therapies for patients with mCRPC. High expression of galectin-1 (Gal-1) is associated with prostate cancer progression and poor clinical outcome. The role of Gal-1 in tumor progression is largely unknown. Here, we characterized Gal-1 functions and evaluated the therapeutic effects of a newly developed Gal-1 inhibitor, LLS30, in mCRPC.Experimental Design: Cell viability, colony formation, migration, and invasion assays were performed to examine the effects of inhibition of Gal-1 in CRPC cells. We used two human CRPC xenograft models to assess growth-inhibitory effects of LLS30. Genome-wide gene expression analysis was conducted to elucidate the effects of LLS30 on metastatic PC3 cells.Results: Gal-1 was highly expressed in CRPC cells, but not in androgen-sensitive cells. Gal-1 knockdown significantly inhibited CRPC cells' growth, anchorage-independent growth, migration, and invasion through the suppression of androgen receptor (AR) and Akt signaling. LLS30 targets Gal-1 as an allosteric inhibitor and decreases Gal-1–binding affinity to its binding partners. LLS30 showed in vivo efficacy in both AR-positive and AR-negative xenograft models. LLS30 not only can potentiate the antitumor effect of docetaxel to cause complete regression of tumors, but can also effectively inhibit the invasion and metastasis of prostate cancer cells in vivo.Conclusions: Our study provides evidence that Gal-1 is an important target for mCRPC therapy, and LLS30 is a promising small-molecule compound that can potentially overcome mCRPC. Clin Cancer Res; 24(17); 4319–31. ©2018 AACR.