bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Prospective Multicenter Analysis of Mobile Stroke Unit Cost‐Effectiveness
Authors: Rajan Suja S. , Yamal Jose‐Miguel , Wang Mengxi , Saver Jeffrey L. , Jacob Asha P. , Gonzales Nicole R. , Ifejika Nneka , Parker Stephanie A. , Ganey Christopher , Gonzalez Michael O. , Lairson David R. , Bratina Patti L. , Jones William J. , Mackey Jason S. , Lerario Mackenzie P. , Navi Babak B. , Alexandrov Ann W. , Alexandrov Andrei , Nour May , Spokoyny Ilana , Bowry Ritvij , Czap Alexandra L. , Grotta James C. 
Published: December 2024

ObjectiveGiven the high disease and cost burden of ischemic stroke, evaluating the clinical efficacy and cost‐effectiveness of new approaches to prevent and treat ischemic stroke is critical. Effective ischemic stroke management depends on timely administration of thrombolytics after stroke onset. This study evaluates the cost‐effectiveness associated with the use of mobile stroke units (MSUs) to expedite tissue plasminogen activator (tPA) administration, as compared with standard management through emergency medical services (EMS).MethodsThis study is a prospective, multicenter, alternating‐week, cluster‐controlled trial of MSU versus EMS. One‐year and life‐time cost‐effectiveness analyses, using the incremental cost‐effectiveness ratio (ICER) method, were performed from the perspective of CMS's Medicare. Quality‐adjusted life years (QALYs) estimated using patient‐reported EQ‐5D‐5L data were used as the effectiveness measure. Health care utilizations were converted to costs using average national Medicare reimbursements. ICERs excluding patients with pre‐existing disability, and limited to stroke‐related costs were also calculated.ResultsThe first‐year ICER for all tPA‐eligible patients using total cost differences between MSU and EMS groups was $238,873/QALY; for patients without pre‐existing disability was $61,199/QALY. The lifetime ICERs for all tPA‐eligible patients and for those without pre‐existing disability were $94,710 and $31,259/QALY, respectively. All ICERs were lower when restricted to stroke‐related costs and were highly dependent on the number of patients treated per year in an MSU.InterpretationMSUs' cost‐effectiveness is borderline if we consider total first‐year costs and outcomes in all tPA‐eligible patients. MSUs are cost‐effective to highly cost‐effective when calculations are based on patients without pre‐existing disability, patients' lifetime horizon, stroke‐related costs, and more patients treated per year in an MSU. ANN NEUROL 2025;97:209–221
Wechselseitige Abhängigkeit zwischen Membranphasentrennung und Dynamik bakterieller Zellteilungsproteine in synthetischen Zellmodellen
Authors: Kanwa Nishu , Kohyama Shunshi , Fröhlich Leonard , Desai Amogh , Schwille Petra 
Published: December 2024

AbstractZellmembranen in Bakterien sind lateral polarisiert, um spezifische Umgebungen für Membranproteine zu schaffen, z. B. für Proteine, die an der Zellteilung beteiligt sind und sich in der Zellmitte oder an den Zellpolen ansammeln. Ein interessantes Ergebnis dieses Zusammenspiels von Membranlipiden ist die Reorganisation von Lipiddomänen zusammen mit membrangebundenen Proteinen zu Beginn der Zellteilung, was auf eine funktionelle Bedeutung von Membrankompartimenten im Zellzyklus schließen lässt. Anhand der wichtigen bakteriellen Teilungsproteine MinC, MinD, MinE, FtsA und FtsZ als archetypisches System zur Bildung räumlicher Muster stellen wir hier ein einfaches vesikelbasiertes in vitro Modell vor, um die gegenseitige Abhängigkeit von Proteinmusterbildung und Membranheterogenität zu untersuchen. Wie viele andere periphere Membranproteine zeigen Min‐Proteine bei der makroskopischen Musterbildung eine bevorzugte Membranbindung an Ld Domänen, was zu einer veränderten Selektion der Oszillationsmodi in phasengetrennten Vesikeln (GUVs) führt. Darüber hinaus führt der Einschluss von bakteriellen Teilungsproteinen in phasengetrennte GUVs zu blebbing‐ähnlichen Membrandeformationen, gefolgt von einer Reorganisation der Lo Domänen an der Halsregion des Blebs. Dies korrespondiert gut mit der Domänenumordnung in bakteriellen Membranen, die dem radialen Einschnürungsprozess unmittelbar vorausgeht. Insgesamt stellt das vorgestellte in vitro Modellsystem einen grundlegenden Rahmen dar, um den Mechanismus der Zellteilung unter Berücksichtigung komplexer zellulärer Lipidumgebungen besser zu verstehen.
Chiral Pd2L4 Capsules from Readily Accessible Tröger's Base Ligands Inducing Circular Dichroism on Fullerenes C60 and C70
Authors: Benchimol Elie , O'Connor Helen M. , Schmidt Björn , Bogo Nicola , Holstein Julian J. , Lovitt June I. , Shanmugaraju Sankarasekaran , Stein Christopher J. , Gunnlaugsson Thorfinnur , Clever Guido H. 
Published: December 2024

AbstractThe induction of chirality on pristine fullerenes through non‐covalent embedding in an asymmetric nano‐confinement has only been rarely reported. Bringing molecules with such a unique electronic structure and broad application range into a chiral environment is particularly appealing for the development of chiroptical materials, enantioselective photoredox catalysts and systems showing chirality‐induced spin selectivity (CISS). In this study, we report the formation of a chiral, configurationally stable Pd2L4 capsule assembled from a C2‐symmetric, ‘ribbon‐shaped’ ligand with a Tröger's base naphthalimide (TbNaps) backbone, easily synthesized in three steps from commercially available compounds. Embedding chirality directly into the ligand backbone ensures a relatively lightweight receptor design whose aromatic panels create a strongly shielded inner cavity of about 700 Å3 volume. Fullerenes C60 and C70, as well as a pair of corannulenes, can be bound in acetonitrile (where unsubstituted fullerenes are insoluble) and X‐ray structures of host‐guest complexes were obtained. Tight interactions between the chiral host and the fullerene guests leads to the induction of a circular dichroism (CD) on the characteristic absorption bands of the forbidden π–π* transitions of the fullerenes, backed up by sTDA TD‐DFT calculations and detailed investigation of the electronic excited states.
Reaction‐Diffusion and Crystallization Kinetics Modulation of Two‐Step Deposited Tin‐Based Perovskite Film via Reducing Atmosphere
Authors: Zhou Hongbo , Sheng Wangping , Rao Huan , Su Yang , Zhu Wenjian , Zhong Yang , Liu Yikun , He Jiacheng , Tan Licheng , Chen Yiwang 
Published: December 2024

AbstractThe two‐step deposition method effectively mitigates the efficiency decline observed in tin‐based perovskite solar cells (TPVSCs) with increasing cell area, stemming from film in‐homogeneity. However, the high solubility of SnI2 in the conventionally used solvent isopropyl alcohol, coupled with the absence of effective modulation of reaction‐diffusion process, results in inadequate film coverage and conversion. In this study, we introduce formic acid as the second‐step solvent and introduce dithiothreitol (DTT) to regulate reaction‐diffusion/crystallization kinetics meticulously. Moreover, this research underscores a fundamental principle that the suitable binding energy ranging from −1.38 to −10.10 kcal mol−1 between ligands and Sn2+ significantly enhances the effectiveness of two‐step crystallization control. Notably, a uniform perovskite film is achieved on large‐scale substrate, and TPVSCs processed with DTT exhibit the highest efficiencies of 12.68 % for 0.04 cm2 device and 11.30 % for 1 cm2 device among tin‐based perovskite devices in two‐step sequential deposition method, even in the absence of dimethyl sulfoxide. This study lays the groundwork for the potential scale‐up development of lead‐free perovskite solar cells.
Preparation of Expandable Polymer Plugging Agent and Its Application in Water‐Based Drilling Fluid
Authors: Luo YuMei , Shang QingGuo , Hu Hua , Bai Xiaodong 
Published: December 2024

ABSTRACTIn order to reduce the economic loss caused by well leakage and the lag of drilling progress, it is very important to use plugging materials reasonably and effectively. Expandable polymer materials can better fill cracks and holes of different sizes by absorbing water expansion and deforming. In this article, an expandable polymer plugging agent (PSMAN) was prepared by soap‐free emulsion polymerization using methyl methacrylate (MMA), styrene (St), 2‐acrylamide‐2‐methylpropanesulfonic acid (AMPS) as reaction monomers, N‐hydroxymethyl acrylamide (NMA) as a cross‐linking agent, and ammonium persulfate (APS) as initiator. The optimal synthesis conditions were determined by designing the orthogonal experiments, and the various properties of the materials were tested and evaluated. The experimental results show that PSMAN has good high temperature resistance, spherical structure, and median particle size of 15.099 μm, and the water absorption rate of room temperature at 24 h reaches 37.8 g/g, and pressure bearing capacity can reach 5 MPa. The addition of polymer to water‐based drilling fluid can increase the viscosity of drilling fluid and improve the rheological properties of drilling fluid by a small amount. Under normal temperature and medium pressure, the polymer can form a dense film on the surface of the mud cake, thereby reducing the filtration of drilling fluid and effectively improving the stability of the wellbore.
MOF@ Nanofiber Separators for Lithium‐Ion Batteries
Authors: Yanilmaz Meltem , Atik Aleyna , Tosun Murat , Zhang Xiangwu 
Published: December 2024

ABSTRACTThe separator plays a crucial role in determining the safety and performance of lithium‐ion batteries (LIBs) by acting as a mediator between the cathode and anode, preventing electrical contact, and providing channels for ionic transport. Most commercially available LIB separators are polyolefin microporous separators. However, the low melting points of polyolefin separators limit their thermal stability, leading to potential safety issues. Therefore, new alternatives are essential for developing high‐performance batteries. Nylon 6,6 is a promising candidate due to its high thermal stability, low cost, good mechanical strength, and high chemical stability. One effective method to further improve the performance of nylon 6,6 separators is to combine them with Metal–Organic Frameworks (MOFs), which offer a high surface area and tunable morphology. The high surface area and porous structure provided by MOFs can increase ion permeability and allow the electrolyte to move more efficiently, thus improving the battery's charge/discharge rates and enhancing its specific capacity. In this study, ZIF‐8, a small‐pore MOF composed of zinc ions coordinated with 2‐methyl imidazolate ligands, was coated onto nylon 6,6 nanofibers and used as a separator in lithium‐ion batteries. ZIF‐8@nylon 6,6 separators exhibited superior electrochemical properties, with a highly porous structure (76% porosity), high electrolyte uptake (340%), and high ionic conductivity (3.6 mS cm−1). Additionally, these separators showed stable cycling performance over 200 cycles and maintained a high specific capacity even at high C‐rates. The results demonstrate that MOF coating on nylon 6,6 separators is a promising approach for designing high‐performance lithium‐ion batteries.
Probing Into the Annealing Effects on Microstructure and Mechanical Properties of Impact Polypropylene Copolymer With Nodular Crystalline Morphology
Authors: Liu Xueping , Li Chenran , Wu Hao 
Published: December 2024

ABSTRACTThe performance of polypropylene materials in high‐temperature environments is closely linked to changes in their microstructure and properties. For impact polypropylene copolymer (IPC), the evolution of structure induced by annealing remains elusive due to the complex molecular chain structure and phase morphology. Herein, we investigate the effects of the initial crystalline morphology on the microstructure and mechanical properties of IPC after annealing. Results show that melt‐quenched IPC (IPC‐m) exhibits a nodular crystalline morphology. As the annealing temperature (T
a) increases, the mesomorphic phase in IPC‐m progressively transforms into monoclinic α crystals. Simultaneously, both the size of nodular particles and their internal crystalline regions gradually increase, while the initial nodular morphology remains unchanged. Furthermore, the nodular morphology restricts the lateral growth of crystals in IPC‐m, thereby inhibiting the cavitation during stretching and resulting in higher yield strength for annealed IPC‐m. This research sheds light on the microstructure evolution mechanisms and structure–property relationships of IPC and will provide theoretical guidance for the evaluation of service life and performance optimization of polyolefins in harsh environments.
Wetland Species Mapping Using Advanced Technological Measurement
Authors: Mohanty Smrutisikha , Srivastava Prashant K. , Pandey Prem C. , Singh Prachi , Srivastava Sanjeev 
Published: December 2024

ABSTRACTWetlands are pivotal in supporting the natural ecosystem and maintaining biodiversity while being susceptible to anthropogenic activities and climate change. However, monitoring wetlands over a large geographical and temporal extent is challenging. Vegetation health can be considered a good indicator of wetland conditions, and measuring chlorophyll content will provide insight into vegetation health. Linking wetland species mapping from chlorophyll spectral indices to local and regional conservation strategies could improve biodiversity conservation. Here, we apply this to Keetham Lake, India, using machine learning methods (relevance vector model) and hyperspectral measurements. From 10 chlorophyll‐sensitive spectral indices, we identified four as best performing, particularly for: TVI + CCCI + NDRE for calibration and NDRE + TVI for validation data. The least performing combinations were MCARI for calibration and TVI + CCCI + NDRE + MCARI for validation. Overall, we identified that NDRE + TVI was the best‐performing pair of spectral indices for chlorophyll assessment and implementation in wetland species. This approach allows for precise mapping of wetland species, providing data on their extent and the area they cover. By creating a digital database, this method enables long‐term monitoring of changes in wetland species' numbers and distribution, helping to assess trends of increase or decline in freshwater ecosystems. Such strategies are vital for supporting both local and global conservation efforts, offering insights for forward‐looking, data‐driven preservation initiatives.
Seasonal metabolic variation in the essential oil composition of various Tabebuia species and evaluation of their anti‐inflammatory activity in vitro and in silico
Authors: Khaled Nesma , Ibrahim Nehal , Youssef Fadia S. , El‐Ahmady Sherweit H. 
Published: December 2024

AbstractThe seasonal variation in essential oil from four Tabebuia species, T. impetiginosa, T. rosea, T. argentea, and T. guayacan, was explored using gas chromatography–mass spectrometry analysis. A total of 90 components were tentatively identified. Among the four Tabebuia species, the most predominant components in spring were phytol (67.5%), limonene (50.1%), (Z,Z,Z)‐7,10,13‐hexadecatrienal (67.5%), and 1‐octen‐3‐ol (80.4%), respectively. Chemometric discrimination of the four Tabebuia species was performed employing principal component analysis, which classified the samples into three main clusters while the rest of the samples were scattered in the whole plot. The season of collection impact on essential oils composition and yield was illustrated. 5‐Lipooxygenase inhibitory effect of spring season essential oils was assessed, showing that all essential oils exhibited certain inhibition, where T. rosea showed the most potent effect, exhibiting an IC50 value of 1.8 μg/mL, compared to the standard zileuton (0.68 μg/mL). Moreover, an in silico molecular docking study was performed for the predominant metabolites against the 5‐LOX active pocket. Among all the docked compounds, eicosane showed the best fitting score, then norphytane, with ∆G of −38.39 and −29.77 kcal/mol, respectively. Thus, Tabebuia species could offer a natural and relatively safe anti‐inflammatory candidate that requires further clinical trials to be supported.
Evaluating Renal Disease in Pediatric‐Onset Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Disease Course, Outcomes, and Predictors of Outcome
Authors: Toor Kirandeep K. , Chen Audrea , Cabral David A. , Mammen Cherry , Bosman Else S. , Shen Ye , Bone Jeffrey N. , Noone Damien , Al‐Abadi Eslam , Benseler Susanne , Berard Roberta , Bohm Marek , Charuvanij Sirirat , Cook Kathryn , Dancey Paul , Deepak Samundeeswari , Duffy Ciaran , Eberhard Barbara , Elder Melissa , Foell Dirk , Gerstbacher Dana , Heshin‐Bekenstein Merav , Huber Adam , James Karen E. , Kim Susan , Klein‐Gitelman Marisa , Martin Neil , McErlane Flora , Moorthy L. Nandini , Myrup Charlotte , Riley Phil , Shenoi Susan , Sivaraman Vidya , Tanner Tamara , Tarvin Stacey , Wagner‐Weiner Linda , Yeung Rae S. M. , Brown Kelly L. , Morishita Kimberly A. ,   the PedVas Investigators Network
Published: December 2024

ObjectiveWe aimed to study the disease course, outcomes, and predictors of outcome in pediatric‐onset antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) affecting the kidneys.MethodsPatients eligible for this study had a diagnosis of granulomatosis with polyangiitis (GPA), microscopic polyangiitis, or ANCA‐positive pauci‐immune glomerulonephritis, were 18 years or younger at diagnosis, had renal disease defined by biopsy or dialysis dependence, and had clinical data at diagnosis and at either 12 or 24 months. Ambispective data from A Registry for Children with Vasculitis/Pediatric Vasculitis Initiative Registry was used. The primary outcome was inactive renal disease (pediatric vasculitis activity score = 0 or 1) at 12 months. Secondary outcomes included rates of improved renal function and damage within 24 months. Renal function, defined by estimated glomerular filtration rate, was categorized into Kidney Disease Improving Global Outcomes (KDIGO) stages at diagnosis and tested as a predictor of outcome using a proportional‐odds logistic regression model.ResultsA total of 145 patients were included: 68% were female, and 78% had GPA. At 12 months, 83% of patients achieved inactive renal disease; however, 42% had evidence of permanent renal damage. Compared with patients with normal renal function at diagnosis, patients with moderate to severely reduced renal function, or kidney failure at diagnosis, had an odds ratio of 8.62 (P = 0.002; 95% confidence interval [CI] 2.31–32.1) and 26.3 (P < 0.001; 95% CI 6.32–109), respectively, for being in a non‐normal KDIGO category at 12 months.ConclusionThe majority of patients with pediatric AAV achieve inactive renal disease by 12 months; however, almost half have evidence of damage. Renal function at diagnosis is a strong predictor of renal function at 12 months.image
Preparation Techniques for Perovskite Single Crystal Films: From Nucleation to Growth
Authors: Zhou Yawen , Liu Da , Gui Yang Hua , Yang Shuang , Hou Yu 
Published: December 2024

AbstractThickness‐controllable perovskite single crystal films exhibit tremendous potential for various optoelectronic applications due to their capacity to leverage the relationship between diffusion length and absorption depth. However, the fabrication processes have suffered from difficulties in large‐area production and poor quality with abundant surface defects. While post‐treatments, such as passivation and polishing, can provide partial improvement in surface quality, the fundamental solution lies in the direct growth of high‐quality single crystal films. In this work, we firstly summarize the basic principles of nucleation and growth phenomenon of crystalline materials. Advanced growth methods of perovskite single crystal films, including solution‐based, vapor phase epitaxial growth, and top‐down method, are discussed, highlighting their respective advantages and limitations. Finally, we also present future directions and the challenges that lie ahead in perovskite single crystal films.
orexin B alleviates sepsis‐associated lung injury through the attenuation of pulmonary endothelial barrier dysfunction by regulating the rho‐associated coiled‐coil containing protein kinase 2/zonula occludens‐1 (ROCK2/ZO‐1) axis
Authors: Wang Yiyuan , Wan Xiaohong , Li Yusheng 
Published: December 2024

AbstractDysfunction of the alveolar endothelial barrier plays a crucial role in the pathogenesis of septic acute lung injury (ALI). orexin B is a neuropeptide derived from orexin neurons in the lateral hypothalamus and has multiple biological functions. However, the physiological function of orexin B in sepsis is less reported. Here, we aimed to explore the protective effects of orexin B in sepsis‐induced ALI and its underlying mechanisms. In this study, we established an ALI in vivo animal model in mice using cecal ligation and puncture (CLP) and an in vitro ALI model using mouse lung microvascular endothelial cells (MLMECs) induced with lipopolysaccharides (LPS). The animal experiments involved four groups: Sham, Sham+orexin B, CLP, CLP+orexin B. First, our results demonstrate that the levels of serum orexin B but not orexin A were reduced in septic mice. Correspondingly, the expression of orexin type 2 receptor (OX2R), but not orexin type 1 receptor (OX1R), was reduced in the lung tissue of septic mice. Administration of orexin B decreased the mortality in sepsis mice and improved M‐CASS scores. Hematoxylin–eosin (H&E) staining assay demonstrated that administration of orexin B ameliorated histopathological lung injury. orexin B was also found to inhibit the inflammatory response in the lung tissues of septic mice by reducing the expression of tumor necrosis factor α (TNF‐α), interleukin 6 (IL‐6), and recombinant chemokine C‐X‐C‐motif ligand 15 (CXCL15). Additionally, the total cell count and neutrophils in bronchoalveolar lavage fluid (BALF) were reduced by orexin B. Notably, orexin B alleviated vascular endothelial permeability in mice lung tissue by increasing the expression of the tight junction protein zonula occludens‐1 (ZO‐1) and occludin. In vitro experiments demonstrated that orexin B prevented LPS‐induced endothelial permeability in mouse lung microvascular endothelial cells (MLMECs) by upregulating the expression of ZO‐1 and occludin. These effects are mediated by rho‐associated coiled‐coil containing protein kinase 2 (ROCK2). Based on these findings, we conclude that orexin B alleviates sepsis‐induced ALI by ameliorating endothelial permeability of lung microvascular endothelial cells.