bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical course of biliary-type sphincter of Oddi dysfunction: endoscopic sphincterotomy and functional dyspepsia as affecting factors
Authors: Miyatani Hiroyuki , Mashima Hirosato , Sekine Masanari , Matsumoto Satohiro 
Published: August 2019

Background and study aims: The objective of this study was to clarify the effectiveness of treatment selection for biliary-type sphincter of Oddi dysfunction by severe pain frequency and the risk factors for recurrence including the history of functional gastrointestinal disorder. Patients and methods: Thirty-six sphincter of Oddi dysfunction patients who were confirmed endoscopic retrograde cholangiopancreatography enrolled in this study. Endoscopic sphincterotomy was performed for type I and manometry-confirmed type II sphincter of Oddi dysfunction patients with severe pain (⩾2 times/year; endoscopic sphincterotomy group). Others were treated medically (non-endoscopic sphincterotomy group). Results: The short-term effectiveness rate of endoscopic sphincterotomy was 91%. The final remission rates of the endoscopic sphincterotomy and non-endoscopic sphincterotomy groups were 86% and 100%, respectively. Symptoms relapsed after endoscopic sphincterotomy in 32% of patients. Patients in the endoscopic sphincterotomy and non-endoscopic sphincterotomy groups had or developed functional dyspepsia in 41% and 14%, irritable bowel syndrome in 5% and 14%, and gastroesophageal reflux disorder in 14% and 0%, respectively. History or new onset of functional dyspepsia was related to recurrence on multivariate analysis. The frequency of occurrence of post-endoscopic retrograde cholangiopancreatography pancreatitis and post-endoscopic retrograde cholangiopancreatography cholangitis was high in both groups. Two new occurrences of bile duct stone cases were observed in each group. Conclusion: According to the treatment criteria, endoscopic and medical treatment for biliary-type sphincter of Oddi dysfunction has high effectiveness, but recurrences are common. Recurrences may be related to new onset or a history of functional dyspepsia.
Marine controlled-source electromagnetic of the Scarborough gas field — Part 3: Multicomponent 2D magnetotelluric/controlled-source electromagnetic inversions
Authors: Constable Steven , Orange Arnold , Myer David 
Published: August 2019

We carried out a multicomponent electromagnetic (EM) survey of the Scarborough gas field in 950 m water on the northwest Australian shelf. Magnetotelluric (MT) data, along with transmitter inline horizontal electric (Ey), vertical electric (Ez), and horizontal magnetic (Bx) field controlled-source electromagnetic (CSEM) data were collected. The Scarborough reservoir is a challenging EM target because it lies between a resistive overlying siltstone and a resistive basement. We carried out 2D inversions of various data combinations to determine how well they recover the expected geology. In particular, we examined the value of the vertical electric CSEM fields. Individual inversions of the Ey and Bx components generate almost identical models, suggesting that these two data sets do not carry independent data, although model studies suggest that this may not be the case in shallower water. Both models smear the siltstone, reservoir, and basement resistors together. The Ez-only inversion includes a resistor with a clear lateral extent at reservoir depths that is separated from basement, but when combined with other CSEM components, Ez provides only marginal improvements in resolution. Not surprisingly, an MT-only inversion is blind to the thin reservoir resistor but combined with CSEM data produces a clear separation of the reservoir from the basement. The combination of Ey, MT, and Ez also separates the siltstone horizon from the reservoir. The sensitivity of MT to horizontal conductivity makes it a powerful complement to the standard Ey CSEM data. The Ez CSEM component adds some value, but perhaps not commensurate with the logistical costs of data collection. The horizontal magnetic CSEM field appears to add little value at these water depths, but if simultaneous MT data are being collected, this component will be available at little cost.
T-Cell Receptor Gene Therapy for Human Papillomavirus–Associated Epithelial Cancers: A First-in-Human, Phase I/II Study
Authors: Doran Stacey L. , Stevanović Sanja , Adhikary Sabina , Gartner Jared J. , Jia Li , Kwong Mei Li M. , Faquin William C. , Hewitt Stephen M. , Sherry Richard M. , Yang James C. , Rosenberg Steven A. , Hinrichs Christian S. 
Published: August 2019

PURPOSE Genetically engineered T-cell therapy is an emerging treatment of hematologic cancers with potential utility in epithelial cancers. We investigated T-cell therapy for the treatment of metastatic human papillomavirus (HPV)–associated epithelial cancers. METHODS This phase I/II, single-center trial enrolled patients with metastatic HPV16-positive cancer from any primary tumor site who had received prior platinum-based therapy. Treatment consisted of autologous genetically engineered T cells expressing a T-cell receptor directed against HPV16 E6 (E6 T-cell receptor T cells), a conditioning regimen, and systemic aldesleukin. RESULTS Twelve patients were treated in the study. No dose-limiting toxicities were observed in the phase I portion. Two patients, both in the highest-dose cohort, experienced objective tumor responses. A patient with three lung metastases experienced complete regression of one tumor and partial regression of two tumors, which were subsequently resected; she has no evidence of disease 3 years after treatment. All patients demonstrated high levels of peripheral blood engraftment with E6 T-cell receptor T cells 1 month after treatment (median, 30%; range, 4% to 53%). One patient’s resistant tumor demonstrated a frameshift deletion in interferon gamma receptor 1, which mediates response to interferon gamma, an essential molecule for T-cell–mediated antitumor activity. Another patient’s resistant tumor demonstrated loss of HLA-A*02:01, the antigen presentation molecule required for this therapy. A tumor from a patient who responded to treatment did not demonstrate genetic defects in interferon gamma response or antigen presentation. CONCLUSION Engineered T cells can induce regression of epithelial cancer. Tumor resistance was observed in the context of T-cell programmed death-1 expression and defects in interferon gamma and antigen presentation pathway components. These findings have important implications for development of cellular therapy in epithelial cancers.
Associations of Physical Activity With Survival and Progression in Metastatic Colorectal Cancer: Results From Cancer and Leukemia Group B (Alliance)/SWOG 80405
Authors: Guercio Brendan J. , Zhang Sui , Ou Fang-Shu , Venook Alan P. , Niedzwiecki Donna , Lenz Heinz-Josef , Innocenti Federico , O’Neil Bert H. , Shaw James E. , Polite Blase N. , Hochster Howard S. , Atkins James N. , Goldberg Richard M. , Sato Kaori , Ng Kimmie , Van Blarigan Erin , Mayer Robert J. , Blanke Charles D. , O’Reilly Eileen M. , Fuchs Charles S. , Meyerhardt Jeffrey A. 
Published: August 2019

PURPOSERegular physical activity is associated with reduced risk of recurrence and mortality in patients with nonmetastatic colorectal cancer. Its influence on patients with advanced/metastatic colorectal cancer (mCRC) has been largely unexplored.PATIENTS AND METHODSWe conducted a prospective cohort study nested in Cancer and Leukemia Group B (Alliance)/SWOG 80405 (ClinicalTrials.gov identifier: NCT00265850 ), a National Cancer Institute–sponsored phase III trial of systemic therapy for mCRC. Within 1 month after therapy initiation, patients were invited to complete a validated questionnaire that reported average physical activity over the previous 2 months. On the basis of responses, we calculated metabolic equivalent task (MET) hours per week to quantify physical activity. The primary end point of the clinical trial and this companion study was overall survival (OS). Secondary end points included progression-free survival (PFS) and first grade 3 or greater treatment-related adverse events. To minimize confounding by poor and declining health, we excluded patients who experienced progression or died within 60 days of activity assessment and used Cox proportional hazards regression analysis to adjust for known prognostic factors, comorbidities, and weight loss.RESULTSThe final cohort included 1,218 patients. Compared with patients engaged in less than 3 MET hours per week of physical activity, patients engaged in 18 or more MET hours per week experienced an adjusted hazard ratio for OS of 0.85 (95% CI, 0.71 to 1.02; PTrend= .06) and for PFS of 0.83 (95% CI, 0.70 to 0.99; PTrend= .01). Compared with patients engaging in less than 9 MET hours per week, patients engaging in 9 or more MET hours per week experienced an adjusted hazard ratio for grade 3 or greater treatment-related adverse events of 0.73 (95% CI, 0.62 to 0.86; PTrend< .001).CONCLUSIONAmong patients with mCRC in Cancer and Leukemia Group B (Alliance)/SWOG 80405, association of physical activity with OS was not statistically significant. Greater physical activity was associated with longer PFS and lower adjusted risk for first grade 3 or greater treatment-related adverse events.
Plasma Metabolomics to Identify and Stratify Patients With Impaired Glucose Tolerance
Authors: Wildberg Charlotte , Masuch Annette , Budde Kathrin , Kastenmüller Gabi , Artati Anna , Rathmann Wolfgang , Adamski Jerzy , Kocher Thomas , Völzke Henry , Nauck Matthias , Friedrich Nele , Pietzner Maik 
Published: August 2019

Abstract

Objective
Impaired glucose tolerance (IGT) is one of the presymptomatic states of type 2 diabetes mellitus and requires an oral glucose tolerance test (OGTT) for diagnosis. Our aims were twofold: (i) characterize signatures of small molecules predicting the OGTT response and (ii) identify metabolic subgroups of participants with IGT.

Methods
Plasma samples from 827 participants of the Study of Health in Pomerania free of diabetes were measured using mass spectrometry and proton-nuclear magnetic resonance spectroscopy. Linear regression analyses were used to screen for metabolites significantly associated with the OGTT response after 2 hours, adjusting for baseline glucose and insulin levels as well as important confounders. A signature predictive for IGT was established using regularized logistic regression. All cases with IGT (N = 159) were selected and subjected to unsupervised clustering using a k-means approach.

Results and Conclusion
In total, 99 metabolites and 22 lipoprotein measures were significantly associated with either 2-hour glucose or 2-hour insulin levels. Those comprised variations in baseline concentrations of branched-chain amino ketoacids, acylcarnitines, lysophospholipids, or phosphatidylcholines, largely confirming previous studies. By the use of these metabolites, subjects with IGT segregated into two distinct groups. Our IGT prediction model combining both clinical and metabolomics traits achieved an area under the curve of 0.84, slightly improving the prediction based on established clinical measures. The present metabolomics approach revealed molecular signatures associated directly to the response of the OGTT and to IGT in line with previous studies. However, clustering of subjects with IGT revealed distinct metabolic signatures of otherwise similar individuals, pointing toward the possibility of metabolomics for patient stratification.
A Knotty Problem: Consumer Access and the Regulation of Provider Networks
Authors: Haeder Simon F. , Weimer David L. , Mukamel Dana B. 
Published: August 2019

Abstract
In order to increase access to medical services, expanding coverage has long been the preferred solution of policy makers and advocates alike. The calculus appeared straightforward: provide individuals with insurance, and they will be able to see a provider when needed. However, this line of thinking overlooks a crucial intermediary step: provider networks. As provider networks offered by health insurers link available medical services to insurance coverage, their breadth mediates access to health care. Yet the regulation of provider networks is technically, logistically, and normatively complex. What does network regulation currently look like and what should it look like in the future? We take inventory of the ways private and public entities regulate provider networks. Variation across insurance programs and products is truly remarkable, not grounded in empirical justification, and at times inherently absurd. We argue that regulators should be pragmatic and focus on plausible policy levers. These include assuring network accuracy, transparency for consumers, and consumer protections from grievous inadequacies. Ultimately, government regulation provides an important foundation for ensuring minimum levels of access and providing consumers with meaningful information. Yet, information is only truly empowering if consumers can exercise at least some choice in balancing costs, access, and quality.
Myths We Live By
Authors: Plaskow Judith 
Published: August 2019

Abstract
In responding to Joy Ladin's reparative reading of Genesis 1–3, the article argues that what is most salient about the biblical narrative is its inscription of male dominance and linking of male dominance to compulsory heterosexuality. In Genesis 1, the existence of a male/female binary is declared foundational to creation. In Genesis 2, we learn that this binary is not innocent, that however much the woman is like the man, the man, in telling the story, has allotted precedence to himself. In Genesis 3, male precedence is depicted as affirmed by God in a way that ties it to both Eve's gender role and heterosexual coupledom. While this is not a reading that is recuperative from a transgender perspective, it does show clearly what is potentially at stake in a transgender critique. If the creation narrative ties together sexual differentiation, gender roles, male dominance, and heterosexuality, questioning the notion of a sexual binary and the necessary entanglement of sex and gender threatens—or promises—to unravel this whole fabric. Every node in the complex interconnections posited by Genesis is based on a binary: male/female, masculine/feminine, male/masculine over female/feminine, homosexual/heterosexual. To challenge the seemingly clear and irrefutable given, the male/female binary, is to leave the others without foundation.
Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential
Authors: Allen Tyler A. , Asad Dana , Amu Emmanuel , Hensley M. Taylor , Cores Jhon , Vandergriff Adam , Tang Junnan , Dinh Phuong-Uyen , Shen Deliang , Qiao Li , Su Teng , Hu Shiqi , Liang Hongxia , Shive Heather , Harrell Erin , Campbell Connor , Peng Xinxia , Yoder Jeffrey A. , Cheng Ke 
Published: August 2019

ABSTRACT
Metastasis accounts for the majority of all cancer deaths, yet the process remains poorly understood. A pivotal step in the metastasis process is the exiting of tumor cells from the circulation, a process known as extravasation. However, it is unclear how tumor cells extravasate and whether multicellular clusters of tumor cells possess the ability to exit as a whole or must first disassociate. In this study, we use in vivo zebrafish and mouse models to elucidate the mechanism tumor cells use to extravasate. We found that circulating tumor cells exit the circulation using the recently identified extravasation mechanism, angiopellosis, and do so as both clusters and individual cells. We further show that when melanoma and cervical cancer cells utilize this extravasation method to exit as clusters, they exhibit an increased ability to form tumors at distant sites through the expression of unique genetic profiles. Collectively, we present a new model for tumor cell extravasation of both individual and multicellular circulating tumor cells.
This article has an associated First Person interview with the first author of the paper.
Un espectro se cierne sobre Entre Ríos: una aproximación a la acción de los comunistas en la provincia, 1931-1943
Authors: Leyes Rodolfo 
Published: August 2019

El presente trabajo busca reconstruir la actividad política de los comunistas en la provincia de Entre Ríos en el periodo 1931-1943. Siendo el Partido Comunista uno de los de mayor crecimiento en el periodo pre-peronista nos permitirá conocer mejor el estado de aquella fuerza al momento del golpe de junio de 1943. Por lo tanto, nuestra propuesta, resulta relevante debido a la inexistencia de trabajos específicos para una provincia pampeana y periférica. La reconstrucción del proceso histórico se realizará con una variedad de fuentes, algunas inéditas, tal es el caso de los fondos documentales confidenciales del Archivo General de la Nación, complementando con medios de prensa sindical, comercial y de diversos partidos y localidades.
Data analytics to reduce stop-on-fail test in electronics manufacturing
Authors: Herrera Ana Elsa Hinojosa , Stoyanov Stoyan , Bailey Chris , Walshaw Chris , Yin Chunyan 
Published: August 2019

Abstract
The use of data driven techniques is popular in smart manufacturing. Machine learning, statistics or a combination of both have been used to improve processes in electronic manufacturing. This paper presents the application of classical techniques to reduce production cycle time by compacting a production test sequence. This set of tests is run on stop-on-fail scenario for quality assurance of an electronical device. Data generated in the production test-set on stop-on-fail scenario challenges the traditional application of the data driven techniques, because of the missing data characteristic. The developed computational procedures handle this application-specific data attribute. The novelty of this work is in the algorithm developed, which applies classical techniques in an iterative environment, as a strategy to analyse incomplete datasets. Results show that the method can reduce a production test set with parametric and non-parametric tests by building an accurate prognostic model. The results can reduce production cycle time and costs. The paper details and provides discussions on the advantages and limitations of the proposed algorithms.
On the asymptotics of degree structure of configuration graphs with bounded number of edges
Authors: Pavlov Yurii L. , Cheplyukova Irina A. 
Published: August 2019

Abstract
We consider configuration graphs with N vertices. The degrees of vertices are independent identically distributed random variables having the power-law distribution with positive parameter

$\tau .$We study properties of random graphs such that the sum of vertex degrees does not exceed n and the parameter is a random variable uniformly distributed on the interval

$\left[ a,\,\,b \right],0<a<b<\infty .$We find limit distributions of the number

${{\mu }_{r}}$of vertices with degree r for various types of variation of N, n and r.
„Institution“ als Scharnierkonzept zwischen Herrschaft und Widerstand
Authors: Anderl Felix , Wallmeier Philip 
Published: August 2019

ZusammenfassungSoziale Bewegungen fordern Herrschaftsstrukturen heraus und werden gleichzeitig von diesen geprägt und eingehegt. Im Rahmen dieses Aufsatzes machen wir einen konzeptionellen Vorschlag zur empirischen Erforschung dieses dialektischen Verhältnisses indem wir „Institution“ als Scharnierkonzept zwischen Herrschaft und Widerstand vorstellen. Wir zeigen an zwei Fallstudien, dass sich auf diese Weise auch die ansonsten schwer greifbare Ausformung transnationaler neoliberaler Herrschaft in ihrer Wirkungsweise verstehen lässt. An den Extrembeispielen eines stark institutionalisierten transnationalen Advocacy-Netzwerks bei der Weltbank und der anti-institutionellen Kommunenbewegung in den USA zeigen wir, dass Bewegungen - ob sie Institutionen nahestehen oder sich von diesen zurückziehen - von neoliberaler Herrschaft durch einen institutionellen Umarmungsgestus eingehegt werden.
Genetic, epigenetic and biochemical regulation of succinate dehydrogenase function
Authors: Moosavi Behrooz , Zhu Xiao-lei , Yang Wen-Chao , Yang Guang-Fu 
Published: August 2019

Abstract
Succinate dehydrogenase (SDH), complex II or succinate:quinone oxidoreductase (SQR) is a crucial enzyme involved in both the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS), the two primary metabolic pathways for generating ATP. Impaired function of SDH results in deleterious disorders from cancer to neurodegeneration. SDH function is tailored to meet the energy demands in different cell types. Thus, understanding how SDH function is regulated and how it operates in distinct cell types can support the development of therapeutic approaches against the diseases. In this article we discuss the molecular pathways which regulate SDH function and describe extra roles played by SDH in specific cell types.
LncRNA MALAT1 inhibits hypoxia/reoxygenation-induced human umbilical vein endothelial cell injury via targeting the microRNA-320a/RAC1 axis
Authors: Zhu Rongrong , Hu Xiao , Xu Wei , Wu Zhourui , Zhu Yanjing , Ren Yilong , Cheng Liming 
Published: August 2019

Abstract
Angiogenesis is believed to protect against hypoxia/reoxygenation (H/R)-induced cell injury. MALAT1 and microRNA-320a (miR-320a) are involved in cancer angiogenesis. To investigate the function of the MALAT1/miR-320a axis in H/R-induced cell injury, human umbilical vein endothelial cell (HUVEC) angiogenesis was detected using the Cell Counting Kit-8 (CCK-8), Transwell migration, cell adhesion and tube formation assays. The expression of MALAT1 and miR-320a was revealed by quantitative reverse transcription polymerase chain reaction (qRT-PCR). The direct binding relationship between miR-320a and MALAT1 was detected by RNA immunoprecipitation (RIP) and dual luciferase reporter assays. The data indicated that H/R induces angiogenesis injury and that the expression of MALAT1 was augmented in H/R-stimulated HUVECs. Overexpression of MALAT1 alleviated H/R-stimulated HUVEC dysfunction, whereas silencing of MALAT1 exerted the opposite effects. MALAT1 also reduced miR-320a levels in HUVECs. Overexpression of miR-320a repressed the function of MALAT1 on H/R-stimulated HUVECs, whereas inhibition of miR-320a exerted the opposite effect. Additionally, miR-320a inhibition alleviated H/R-stimulated HUVEC injury via RAC1. Taken together, this investigation concluded that MALAT1 represses H/R-stimulated HUVEC injury by targeting the miR-320a/RAC1 axis.
Coordinate transformation parameters in Nepal by using neural network and SVD methods
Authors: Ansari Kutubuddin , Gyawali Prabin , Pradhan Prachand Man , Park Kwan-Dong 
Published: August 2019

Abstract
The present study computes B-W extension model (extended Bursa-Wolf model) coordinate transformation parameters from World Geodetic System 1984 (WGS-84) to the Everest datum namely Everest (1830) and Everest (1956) using records of coordinate measurements from Global Positioning System (GPS) observable across Nepal region. Synthetic or modeled coordinates were determined by using the Artificial Neural Network (ANN) and Singular Value Decomposition (SVD) methods. We studied 9-transformation parameters with the help of the ANN technique and validated the outcomes with the SVD method. The comparative analysis of the ANN, as well as SVD methods, was done with the observed output following one way ANOVA test. The analysis showed that the null hypothesis for both datums were acceptable and suggesting all models statistically significantly equivalent to each other. The outcomes from this study would complement a relatively better understanding of the techniques for coordinate transformation and precise coordinate assignment while assimilating data sets from different resources.