bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE EXPERIENCE WITH ERIBULIN IN REAL CLINICAL PRACTICE FROM MOSCOW AND MOSCOW REGION
Authors: Marphutov V. V. , Filonenko D. V. , Belonogov V. A. , Аndreyashkina I. I. , Byakhov A. V. , Kramskaya L. V. , Karandeeva T. V. , Mehtiyev V. N. , Oskirko D. A. , Suslova I. R. , Skorina M. O. , Romanchuk O. V. , Samyshina M. A. , Shikina V. Е. , Kozlov D. V. , Hrupalo O. V. , Tyuvinova E. V. , Sherstnev V. M. , Chernov I. S. , Kolokolov J. J. , Konopleva E. I. 
Published: July 2018

Introduction.Eribulin, an non-taxane microtubule inhibitor, has been registered in Russia for patients with locally advanced or metastatic breast cancer (mBC) who received at least one chemotherapy regimen for a advanced disease, previous therapy should include anthracyclines and taxanes in adjuvant or metastatic setting, except the patients who could not be prescribed these drugs. We present our experience with eribulin in real clinical practice in Moscow and the Moscow Region.Patients and methods. We conducted a retrospective analysis of the experience with the use of eribulin in Moscow and the Moscow Region in 202 patients with mBC from January 2016 to February 2017 to assess the effectiveness and safety of the drug. All patients received previous therapy with anthracyclines and taxanes for locally advanced and / or metastatic cancer. The average age of patients at the time of inclusion in the analysis was 5 years (28–81). The status of the general condition on the ECOG 0-1 scale was registered in 81.3 % (100 / 123) of patients, the status of ECOG 2-3 in 18.7 % (23 / 123) of patients. The median of the number of courses of chemotherapy with eribulin is 4 (2–17). Patients received eribulin in 1-7 chemotherapy lines for metastatic disease. The average number of affected organs is 2 (1–5).Results.Complete response (CR) was in 3 (2 %) patients. Partial response (PR) was in 24 (15.7 %) patients, stabilization of the disease – in 89 (58. 2 %). Progression of the disease was recorded in 37 (24.1 %) patients. The median of progression-free survival (PFS) on the therapy was 4.64 (95 % CI 2.97-6.87) months. Stabilization of the disease for more than 6 months was registered in 28 (18.3 %) patients. The most significant toxicity was neutropenia and polyneuropathy (21 patients (10.4 %) and 7 patients (3.5 %), respectively).Dose reduction due to neutropenia was required by 26 patients (12.9 %). The objective response rate (ORR) depended on the chemotherapy line: in 1-3 lines the efficacy of the treatment was higher: the ORR was 21.6 %, compared to the 4th and subsequent lines – 12.3 %, respectively. With HER2-positive mBC, eribulin showed clinically significant results in combination with trastuzumab.Conclusions.Our analysis confirms that eribulin has a predictable and manageable safety profile, is an effective drug for the treatment of patients with different subtypes of mBC in a real clinical setting.
Fetal Alcohol Spectrum Disorder: Risk for Diabetes and Congenital Heart Defects
Authors: Salmon Jenny 
Published: July 2018

Excessive use of alcohol can be a cause for many disease and injury conditions. These include amongst many others, myocardial infarction, diabetes mellitus, atrial fibrillation, nonischaemic cardiomyopathy, fetal alcohol spectrum disorder (FASD), congenital heart defects (CHD) and liver cirrhosis. Even low levels of prenatal alcohol ethanol) exposure, such as in a single dose, can produce birth defects termed fetal alcohol syndrome (FAS) which is the highest marker on the spectrum. Diabetes is regarded as a major cause of cardiovascular disease whilst prenatal alcohol exposure (PAE) can range from no observable adverse effects to mortality. CHD are stated to be the most prevalent cause of mortality in individuals with FASD. The dimension of the problems is still greatest in the Western world although it is stated to be the leading cause of mental retardation in North America. FASD is a neurodevelopmental disability which can be occasioned when a pregnant woman consumes alcohol. The diagnostic criteria for FASD includes growth impairment, abnormal facial features and neurocognitive impairments. The most frequently reported abnormal facial features in FASD are thin upper lip, indistinct or smooth philtrum and short palpebral fissure length. Other features are microganthia, low set ears, ptosis, absent or indistinct philtral ridge, epicanthal folds, cleft palate, flat nasal bridge and midface hypoplasia. The neurocognitive features commonly reported in FASD are microcephaly, intellectual disability, attention-deficit hyperactivity disorder (ADHD) and behavioural impairments. Central nervous system (CNS) injury is also seen and is debilitating. Structural abnormalities of the CNS can include microcephaly, agenesis/absence of the corpus callosum and multiple severe brain malformations. This review article seeks to address the association of FASD with diabetes and CHD.
La libertad de expresión y la defensa de los Derechos Humanos en México: Situación actual = Freedom of expression and the defense of Human Rights in Mexico: Current situation
Authors: Villanueva Sossa Selene , Chávez Cervantes José de Jesús 
Published: July 2018

RESUMEN: La libertad de expresión es un derecho aún pendiente por garantizar por parte del Estado mexicano si éste se considera comprometido con el resguardo de los derechos humanos. Prueba de lo anterior, son las numerosas violaciones de sus derechos a periodistas y personas defensoras de derechos humanos, lo que se traduce en un Estado en el que ejercer la libertad de expresión, se puede estar firmando una sentencia de muerte. ABSTRACT: Freedom of expression is a still pending right to be guaranteed by the Mexican State if he considers itself committed with the safeguarding human rights. Proof of the previous text, are the numerous violations to journalist rights and human right defenders, which it translates into a state in which to exercise freedom of expression, could be a death sentence.PALABRAS CLAVE: libertad de expresión, derechos humanos, estado constitucional, México.KEYWORDS: freedom of expression, human rights, constitutional state, Mexico.
Modeling Analysis of Complex Products Resource Integration Behavior Under Distributed Collaborative Technology Innovation Mode
Authors: Chen Hongzhuan , Wang Yue , Song Lulu , Zhang Qiaoke 
Published: July 2018

Abstract
According to new features of distributed technology innovation collaboration of complex products of China’s aviation, in the multi-agent collaborative R&D process, between main manufacturer and suppliers, this paper summarizes the organizational structure and characteristics of collaborative mode of distributed technology innovation of complex products, basing on the technological innovation and resource integration of complex products, and treating resource contribution rate as a key parameter. It establishes multi-agent resource integration collaborative symbiosis model under distributed collaborative technology innovation mode based on symbiosis theory. And finds that some factors such as the basic attributes of the enterprise, the mutual influence of resources among enterprises and the behavior decision of the main manufacturer have some effects on the resource integration using stability analysis and simulation analysis, which provides a theoretical basis for the main manufacturer to optimize the behavior of suppliers’ resource integration.
The Effect of Transportation and Housing Subsidies on Urban Sprawl
Authors: Cai Qiao , Wang Zou , Xiao Lingling 
Published: July 2018

Abstract
This paper analyses theoretically the effect of transportation and housing subsidies on urban sprawl, modal choice decisions and urban spatial structure using a spatial general equilibrium model in a monocentric city with two transport modes. Our analysis shows that public transit subsidy leads to urban shrink, whilst subsidizing automobile and housing make the city sprawl. We also find the effects of the other factors on urban sprawl, such as households income and demand, rural land rent, the income tax rate, the total fixed cost of public transit and automobile and the travelling marginal cost of public transit and automobile. Furthermore, this paper also studies how to maximize the urban-area-wide spatial equilibrium utility level.
Dynamics of Indonesian Robusta Coffee Competition Among Major Competitor Countries
Authors: Rosiana Nia , Nurmalina Rita , Winandi Ratna , Rifin Amzul 
Published: July 2018

<p>Fluctuations in Indonesian Robusta coffee exports occurred along with a declining trend in coffee exports compared to major competitor countries over the past fifteen years. This research aimed to analyze the dynamics of the competitiveness of Indonesian Robusta coffee exports and the level of competition among the major competitor countries such as Vietnam and India. The methods used are <em>Revealed Comparative Advantage</em> (RCA), <em>Dynamic Revealed Comparative Advantage</em> (DRCA), and <em>Rank Spearman Correlation</em>. These methods were selected to analyze changes in competition level within 15 years’ time dimension (2000–2015) as well as to analyze the relationships among competing countries, which may affect Robusta coffee market of each country. The analysis showed that Indonesia's coffee competitiveness tends to increase compared to the two major competitors of Robusta coffee exporter of the world such as Vietnam and India. However, Indonesia's coffee competitiveness is still a half below Vietnam. The Indonesian coffee rivalry against Vietnam and India is not significantly correlated due to the different markets of export destination countries.<em> </em>Increasing competitiveness and the strength of competition in export market can be done through quality improvement and continuity of domestic Robusta coffee in accordance to the demand of world consumers.</p>
The Effectiveness of Trichoderma Viride TNU in Inhibiting Infection of Phytophthora Palmivora on Cocoa
Authors: Samsudin Samsudin , Harni Rita , Taufik Efi 
Published: July 2018

<p>Phytophthora palmivora<em> is a pathogen</em><em>ic fungus</em><em> that causes pod rot and stem cancer in cacao plant. This pathogen was difficult to control because it survives in the form of mycelium and chlamydospores in infected plant parts or in soil. </em>Trichoderma viride<em> is expected to inhibit the growth and development of this pathogen. The study aimed to determine the effectiveness of </em>T. viride<em> in inhibiting </em>P. palmivora<em> infection on cacao, conducted at Plant Protection Laboratory and Greenhouse of Indonesian Industrial and Beverage Crops Research Institute (IIBCRI), Sukabumi from March to December 2014. The </em>T. viride<em> TNU isolates used was purified and propagated in the laboratory. The </em>T. viride<em> inhibition against </em>P. palmivora<em> growth and development was tested in vitro on potato dextrose agar medium (PDA) and in vivo on infected cacao pods and seedlings. The parameters observed were percentage of inhibition on PDA and the disease progression on infected pods and seedlings. The results showed that </em>T. viride<em> inhibited the growth of </em>P. palmivora<em> with inhibition percentage up to 68.60%, a strong antagonist for </em>P. palmivora<em> on PDA and reduced </em>P. palmivora<em> infection on seedlings in the greenhouse. Applications of </em>T. viride<em> 3 days before or after inoculation with </em>P. palmivora<em> was able to protect cacao seedlings in polybags, respectively by 60% and 45%. However, </em>T. viride<em> has not been able to hinder the development of pod rot disease on cacao.</em><em></em></p>
A comparative ideotype, yield component and cultivation value analysis for spring wheat adaptation in Finland
Authors: Laurila Heikki , Mäkelä Pirjo , Kleemola Jouko , Peltonen Jari 
Published: July 2018

In this study Mixed structural covariance, Path and Cultivation Value analyses and the CERES-Wheat crop model were used to evaluate vegetation and yield component variation affecting yield potential between different high-latitude (> 60° N lat.) and mid-European (< 60° N lat.) spring wheat (Triticum aestivum L.) genotypes currently cultivated in southern Finland. Path modeling results from this study suggest that especially grains/ear, harvest index (HI) and maximum 1000 kernel weight were significant factors defining the highest yield potential. Mixed and Cultivation value modeling results suggest that when compared with genotypes introduced for cultivation before 1990s, modern spring wheat genotypes have a significantly higher yielding capacity, current high yielding mid-European genotypes even exceeding the 5 t ha-1 non-potential baseline yield level (yb). Because of a forthcoming climate change, the new high yielding wheat genotypes have to adapt for elevated temperatures and atmospheric CO2 growing conditions in northern latitudes. The optimized ideotype profiles derived from the generic high-latitude and mid-European genotypes are presented in the results. High-latitude and mid-European ideotype profiles with factors estimating the effects of concurrent elevated CO2 and temperature levels with photoperiodical daylength effects can be utilized when designing future high yielding ideotypes adapted to future growing conditions. The CERES-Wheat ideotype modeling results imply, that with new high yielding mid-European ideotypes, the non-potential baseline yield (yb) would be on average 5150 kg ha-1 level (+ 108 %) vs. new high-latitude ideotypes (yb 4770 kg ha-1, 100%) grown under the elevated CO2(700ppm)×temperature(+3ºC) growing conditions projected by the year 2100 climate change scenario in southern Finland.
Effect of lactic acid on the meat quality properties and the taste of pork Serratus ventralis muscle
Authors: Grajales-Lagunes Alicia , Rivera-Bautista Cecilia , Ruiz-Cabrera Miguel , Gonzalez-Garcia Raul , Ramirez-Telles Jorge , Abud-Archila Miguel 
Published: July 2018

In this work was evaluated the effect of lactic acid treatment method in pork Serratus ventralis muscle on meat quality parameters pH, color, weight loss, cooking loss, hardness, and taste. The treatment was performed by immersing the sample in lactic acid solutions at two concentrations (1 and 3% v v-1) for 1 and 3 min., immediately the samples were stored at 4 °C during 7 days. The taste was evaluated employing trained and untrained judges. Only hardness, weight loss and cooking loss, were affected by lactic acid concentration (p<0.05). The perception of lactic acid taste to trained judges was higher in samples of major concentration and immersion time. To untrained judges the sample treated with 3% lactic acid for 1 minute, had the best acceptation. Both judges reported that the taste of meat was delicious. Therefore, lactic acid treatment may be an alternative to extend pork shelf life.
Turkish Adaptation of the Empowering Leadership Scale for Educational Organizations: A Validity and Reliability Study
Authors: KONAN Necdet , ÇELİK O.tayyar 
Published: July 2018

This
study aims to adapt Empowering Leadership Scale developed by Konczak, Stelly
and Trusty, and to carry out reliability and validity analyses for educational
organizations in Turkey. Linguistic validity studies were carried out, and as
it was proved to have linguistic equivalence, the scale was administered to 220
teachers working in Malatya in 2015-2016 academic year. As a consequence of
unreliable results, the sample size was
increased to 421 and statistical analyses were reiterated. Forms of the scale from the one-factor
structure to the seven-factor structure were tested and it was found that the
three-factor structure had

acceptable
fit values. At the end of the validity and reliability studies, a three-factor
Turkish form has been developed and it can be used as a valid and reliable
measurement tool to measure Empowering Leadership behaviors of school
principals.
Maddenin Yapısı ve Özelikleri Ünitesine Yönelik İki Aşamalı Teşhis Testinin Geliştirilmesi
Authors: AVCI Filiz , ACAR ŞEŞEN Burçin , KIRBAŞLAR Fatma Gülay 
Published: July 2018

Çalışmanın amacı,
Ortaokul 7. sınıf öğrencilerinin, Fen Bilimleri dersi kapsamındaki “Maddenin
Yapısı ve Özellikleri” Ünitesinde yer alan belirlenmiş konulara yönelik kavramsal
anlamalarını belirlemek için geçerli ve güvenilir, iki aşamalı teşhis (diagnostik) testi
geliştirmektir. Bu kapsamda, çalışmanın ilk aşamasında mevcut kazanımlar
incelenmiş, gerekli ekle-meler ve düzetmelerin ardından güncellenmiş Bloom
Taksonomosi’ne göre sınıflandırılmıştır. Ardından, alan yazın araştırması
yapılmış ve 47 çoktan seçmeli maddeyi içeren madde havuzu oluşturulmuştur.
Kapsam geçerliğinin sağlanması amacıyla test, dört kimya eğitimcisi ve üç Fen
Bilimleri öğretmeni tarafından değerlendirilmiştir. Test,
33 maddeye indirgenmiş ve farklı okulların 7. sınıflarında öğrenim gören
225 öğrenciye uygulanmıştır. Testin güvenirlik katsayısı 0.91’dir.
Analgesic activity of newly synthesized 7-chloro–2–methyl-4H–benzo[d] [1,3]–oxazin–4–one and 3–amino-7-chloro-2–methyl-quinazolin-4(3H)–one
Authors: Osarumwense Peter O. 
Published: July 2018

Abstract
The current study is aimed at the analgesic evaluation of quinazolinone derivatives. The quinazolinone derivatives 7-chloro-2-methyl-4H-benzo[d][1,3]-oxazin-4-one and 3-amino-7-chloro-2-methyl-quinazolin-4(3H)-one were evaluated pharmacologically for their in vivo analgesic activities by acetic acid induced writhing in mice. The compounds exhibited significant analgesic activity in the range of 74.67 - 83.80% in comparison to control.
Evolution of Project Management as a Scientific Discipline
Authors: Abbasi Alireza , Jaafari Ali 
Published: July 2018

Abstract
In this study, we investigated the quantity and impact of worldwide research production in the field of “project management” over the past 38 years. We performed a bibliometric analysis using the Scopus database between 1980 and 2017 to develop an understanding of the evolution of research on “project management.” Using the knowledge of a domain expert in the field of “project management,” we first compiled a set of reliable keywords, which represented the field. Second, we developed a data extraction strategy for searching the phrase “project management” in the title or keyword or abstract of publications by limiting our sources to journals in English. We observed the evolution of this field by analyzing not only the quantity of publications but also their impact (citations) per year and compared their growth trend in four periods. The results of our analysis confirmed that not only the research themes or topics but also the active parties involved in project management research have experienced phonemic changes over time.
KAJIAN SEMANTIK ETNOGRAFI PADA CERITA RAKYAT JEPANG WARASHIBECHŌJA
Authors: Laksmita Sari Ida Ayu 
Published: July 2018

This study discuss the word and the sentences containing meaning ethnography in Japanese Folklore of Warashibechōja. This study uses the theory of semantic ethnography focusing to the meanings illustrating the local culture system. Through the text story of Warashibechōja data is collected anda analysed using methodes of descriptive qualitative with techniques note. The result of this study is found the word including sonkeigo constituting oral expression which is based on consideration respect towards the interloculator. In addition to, found the culture vacabularies describing Japanese traditional culture, those are wara, miso, furoshiki, uma, and muko. The illustrated Ideology is someone shall try to do from the small thing seriously to get the best result and found also the intention to diffuse religion of Buddhist in Japan.AbstrakPenelitian ini membahas kata serta kalimat yang mengandung makna etnografi pada cerita rakyat Jepang Warashibechōja. Penelitian ini menggunakan teori semantik etnografi yang memfokuskan pada makna-makna yang menggambarkan sistem kebudayaan setempat. Melalui teks cerita Warashibechōja data dikumpulkan dan dianalisis menggunakan metode metode deskriptif kualitatif dengan teknik catat. Hasil dari penelitian ini adalah ditemukannya kata yang termasuk sonkeigo yang merupakan ungkapan tingkat tutur yang didasarkan pada pertimbangan rasa hormat terhadap lawan bicara. Selain itu, ditemukan pula kosakata budaya yang menggambarkan kebudayaan tradisional Jepang, yaitu wara, miso, furoshiki, uma, dan muko. Ideologi yang tergambar adalah seseorang harus berusaha dari hal kecil secara sungguh-sungguh untuk mendapatkan hasil yang terbaik dan terdapat pula maksud untuk menyebarkan agama Buddha di Jepang.
Factores que generan impunidad en el tratamiento judicial de casos de ejecuciones extrajudiciales en Colombia
Authors: Monsalve Boada Mario Samuel 
Published: July 2018

El artículo examinó los principales factores jurídico-políticos que han facilitado la impunidad en Colombia, en los procesos penales relacionados con las ejecuciones extrajudiciales, práctica ilícita realizada por miembros de la fuerza pública para obtener beneficios del Estado, bien sean económicos, licencias, permisos, etc. Las conclusiones señalan que los principales factores que generan impunidad son, entre otros, la inoperancia del aparato judicial del Estado, la acción llevada a cabo por los abogados de la defensa de los miembros de la fuerza pública investigados, así como elementos políticos y sociales orientados no solo a obstaculizar la investigación penal, sino a evitar que se conozca la verdad y los máximos responsables de estos crímenes de lesa humanidad.
Política criminal en Colombia, hacia su constitucionalización
Authors: Rodríguez Sánchez John Jairo 
Published: July 2018

El artículo es fruto de la investigación que se realizó con el objetivo de establecer si la política criminal que se desa-rrolla en Colombia se fundamenta en los principios rectores del sistema acusatorio implementado en el país. Para tal
efecto se identificaron las investigaciones y orientaciones teóricas que se han formulado, se expone el estado de lasdiscusiones en cuanto al manejo de la política criminal en Colombia, y en el último capítulo se presenta una propuestateórico práctica cimentada en lo que se propuso como sistema de enjuiciamiento criminal colombiano, esto es, unsistema acusatorio. La investigación tuvo como derrotero los pilares y los principios que originan estos sistemas, porello la propuesta que se ofrece se hace desde este marco que es el que, en últimas, inspira teleológicamente el sistema.
SISTEM PAKAR PENENTUAN MOTIF DAN WARNA BATIK BERDASARKAN CIRI FISIK DENGAN METODE FORWARD CHAINING
Authors: Dhenabayu Riska , Sari Hesty Puspita , Yunita Sari Silviana Valyanda 
Published: July 2018

Membatik merupakan teknik menghias kain tradisional Indonesia dengan menggunakan lilin untuk membuat pola dan desain. Penggunaan batik antara satu individu dengan individu lainnya memang berbeda, bergantung dari ciri fisik dan karakter pemakai agar terlihat bagus, elegan, dan jragem (berwibawa). Kesesuaian pengguna batik ini merupakan hal yang penting mengingat kebutuhan masyarakat terhadap penampilan yang nyaman, pantas, dan menarik. Ingatan manusia dan ahli yang memahami batik sangatlah terbatas, maka diperlukan sebuah sistem untuk menjaga salah satu warisan budaya ini agar bisa bertahan. Tujuan dari penelitian ini adalah untuk mengembangkan dan menerapkan basis pengetahuan dan sistem pakar yang dapat dengan cepat mencocokan batik yang sesuai dengan ciri fisik pengguna khususnya batik Blitar. Sistem ini akan menarik kesimpulan dari beberapa jenis masukan yang masuk ke sistem berdasarkan warna kulit, ukuran pakaian, usia, dan jenis kelamin. Program ini menggunakan PHP sebagai bahasa pemrograman dan MySQL sebagai basis data sistem.