bluuebunny/crossref_metadata_2025_split huggingface dataset:
BIOMASS OF WILD RICE (Oryza rufipogon) AT TRAM CHIM NATIONAL PARK, DONG THAP PROVINCE
Authors: Le Thang Trong , Truong Dan Hoang , Bui My Thi Yen , Lam Tuan Hoang 
Published: June 2019

This study was carried out to evaluate the status of Wild Rice (Oryza rufipogon) biomass at Tram Chim National Park, Dong Thapprovince for the preservation of biomes and forest fire prevention. The samples had been collected by randomly design with 9 standard plots and each standard plot contains 3 subplots with 1m × 1m in size. The characteristics were assessed including mass, height, water levels and biomass of Wild Rice at each plot. The results showed that the Wild Rice community appeared in 27 samling plots with a total area of 697.8 ha in which the lowest and highest areas of Wild Rice were respectively 1.3 ha and 162.3 ha. In addition, the fresh and dry biomass in each community were 44.85±23.1 tonnes/ha and 9.24±3.37 tonnes/ha, respectively. The relationship between water depth and vegetation active-layer thickness were closely correlated (r = 0.71).
Evolution of the Gas Mass Fraction of Progenitors to Today’s Massive Galaxies: ALMA Observations in the CANDELS GOODS-S Field
Authors: Wiklind Tommy , Ferguson Henry C. , Guo Yicheng , Koo David C. , Kocevski Dale , Mobasher Bahram , Brammer Gabriel B. , Kassin Susan , Koekemoer Anton M. , Giavalisco Mauro , Papovich Casey , Ravindranath Swara , Faber Sandra M. , Freundlich Jonathan , de Mello Duilia F. 
Published: June 2019

Abstract
We present an Atacama Large Millimeter/submillimeter Array (ALMA) survey of dust continuum emission in a sample of 70 galaxies in the redshift range z = 2–5 selected from the CANDELS GOODS-S field. Multi-epoch abundance matching (MEAM) is used to define potential progenitors of a z = 0 galaxy of stellar mass 1.5 × 1011
M
⊙. Gas masses are derived from the 850 μm luminosity. Ancillary data from the CANDELS GOODS-S survey are used to derive the gas mass fractions. The results at z ≲ 3 are mostly in accord with expectations: The detection rates are 75% for the z = 2 redshift bin, 50% for the z = 3 bin, and 0% for z ≳ 4. The average gas mass fraction for the detected z = 2 galaxies is f
gas = 0.55 ± 0.12 and f
gas = 0.62 ± 0.15 for the z = 3 sample. This agrees with expectations for galaxies on the star-forming main sequence, and shows that gas fractions have decreased at a roughly constant rate from z = 3 to z = 0. Stacked images of the galaxies not detected with ALMA give upper limits to f
gas of <0.08 and <0.15, for the z = 2 and z = 3 redshift bins. None of our galaxies in the z = 4 and z = 5 sample are detected, and the upper limit from stacked images, corrected for low metallicity, is f
gas < 0.66. We do not think that lower gas-phase metallicities can entirely explain the lower dust luminosities. We briefly consider the possibility of accretion of very low-metallicity gas to explain the absence of detectable dust emission in our galaxies at z ≳ 4.
Search for Nearby Earth Analogs. I. 15 Planet Candidates Found in PFS Data*
Authors: Feng Fabo , Crane Jeffrey D. , Wang Sharon Xuesong , Teske Johanna K. , Shectman Stephen A. , Díaz Matías R. , Thompson Ian B. , Jones Hugh R. A. , Butler R. Paul 
Published: June 2019

Abstract
The radial velocity (RV) method plays a major role in the discovery of nearby exoplanets. To efficiently find planet candidates from the data obtained in high-precision RV surveys, we apply a signal diagnostic framework to detect RV signals that are statistically significant, consistent in time, robust in the choice of noise models, and do not correlated with stellar activity. Based on the application of this approach to the survey data of the Planet Finder Spectrograph, we report 15 planet candidates located in 14 stellar systems. We find that the orbits of the planet candidates around HD 210193, 103949, 8326, and 71135 are consistent with temperate zones around these stars (where liquid water could exist on the surface). With periods of 7.76 and 15.14 days, respectively, the planet candidates around star HIP 54373 form a 1:2 resonance system. These discoveries demonstrate the feasibility of automated detection of exoplanets from large RV surveys, which may provide a complete sample of nearby Earth analogs.
Spatial mismatch, education and language skills in the Brussels metropolis: an analysis
Authors: Theys Tobias , Deschacht Nick , Adriaensens Stef , Verhaest Dieter 
Published: June 2019

Spatial mismatch, where job seekers do not live where jobs can be found, can be an important barrier on the labour market, especially for vulnerable groups. In this study we look at the role that spatial mismatch plays in the Brussels metropolis. Using an improved benchmark, the distance-weighted spatial mismatch index, that also considers location-driven mismatch, we compare the spatial mismatch between the high- and low-skilled labour market and the labour market for the low-skilled with and without language skills. In the largest possible definition of the Brussels metropolis, results show a spatial mismatch of up to 50 % larger for the low-skilled, in comparison with the high-skilled. For the low-skilled without language skills, the spatial mismatch is 115 % higher than for the low-skilled with language skills. This difference is mainly due to a relative surplus of low-skilled job seekers (without language skills) in the Brussels-Capital Region and a relative shortage in the first belt of municipalities around the Region.
The Alzheimer’s Disease–Associated Protein BACE1 Modulates T Cell Activation and Th17 Function
Authors: Hernandez-Mir Gerard , Raphael Itay , Revu Shankar , Poholek Catherine H. , Avery Lyndsay , Hawse William F. , Kane Lawrence P. , McGeachy Mandy J. 
Published: June 2019

Abstract
β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is best known for its role in Alzheimer's disease amyloid plaque formation but also contributes to neurodegenerative processes triggered by CNS injury. In this article, we report that BACE1 is expressed in murine CD4+ T cells and regulates signaling through the TCR. BACE1-deficient T cells have reduced IL-17A expression under Th17 conditions and reduced CD73 expression in Th17 and inducible T regulatory cells. However, induction of the Th17 and T regulatory transcription factors RORγt and Foxp3 was unaffected. BACE1-deficient T cells showed impaired pathogenic function in experimental autoimmune encephalomyelitis. These data identify BACE1 as a novel regulator of T cell signaling pathways that impact autoimmune inflammatory T cell function.
Treatment of Experimental Autoimmune Encephalomyelitis by Sustained Delivery of Low-Dose IFN-α
Authors: Vasquez Marcos , Consuegra-Fernández Marta , Aranda Fernando , Jimenez Aitor , Tenesaca Shirley , Fernandez-Sendin Myriam , Gomar Celia , Ardaiz Nuria , Di Trani Claudia Augusta , Casares Noelia , Lasarte Juan Jose , Lozano Francisco , Berraondo Pedro 
Published: June 2019

AbstractMultiple sclerosis (MS) is a chronic autoimmune disease with no curative treatment. The immune regulatory properties of type I IFNs have led to the approval of IFN-β for the treatment of relapsing-remitting MS. However, there is still an unmet need to improve the tolerability and efficacy of this therapy. In this work, we evaluated the sustained delivery of IFN-α1, either alone or fused to apolipoprotein A-1 by means of an adeno-associated viral (AAV) system in the mouse model of myelin oligodendrocyte glycoprotein–induced experimental autoimmune encephalomyelitis. These in vivo experiments demonstrated the prophylactic and therapeutic efficacy of the AAV–IFN-α or AAV–IFN-α fused to apolipoprotein A-1 vectors in experimental autoimmune encephalomyelitis, even at low doses devoid of hematological or neurologic toxicity. The sustained delivery of such low-dose IFN-α resulted in immunomodulatory effects, consisting of proinflammatory monocyte and T regulatory cell expansion. Moreover, encephalitogenic T lymphocytes from IFN-α–treated mice re-exposed to the myelin oligodendrocyte glycoprotein peptide in vitro showed a reduced proliferative response and cytokine (IL-17A and IFN-γ) production, in addition to upregulation of immunosuppressive molecules, such as IL-10, IDO, or PD-1. In conclusion, the results of the present work support the potential of sustained delivery of low-dose IFN-α for the treatment of MS and likely other T cell–dependent chronic autoimmune disorders.
A conservation palaeobiological approach to assess faunal response of threatened biota under natural and anthropogenic environmental change
Authors: van de Velde Sabrina , Jorissen Elisabeth L. , Neubauer Thomas A. , Radan Silviu , Pavel Ana Bianca , Stoica Marius , Van Baak Christiaan G. C. , Martínez Gándara Alberto , Popa Luis , de Stigter Henko , Abels Hemmo A. , Krijgsman Wout , Wesselingh Frank P. 
Published: June 2019

Abstract. Palaeoecological records are required to test ecological
hypotheses necessary for conservation strategies as short-term observations
can insufficiently capture natural variability and identify drivers of
biotic change. Here, we demonstrate the importance of an integrated
conservation palaeobiology approach when making validated decisions for
conservation and mitigating action. Our model system is the Razim–Sinoie
lake complex (RSL) in the Danube Delta (Black Sea coast, Romania), a dynamic
coastal lake system hosting unique Pontocaspian mollusc species that are now
severely under threat. The Pontocaspians refer to an endemic species group
that evolved in the Black Sea and Caspian Sea basins under reduced salinity
settings over the past few million years. The natural, pre-industrial RSL
contained a salinity gradient from fresh to mesohaline (18 ppm) until human
intervention reduced the inflow of mesohaline Black Sea water into the lake
system. We reconstruct the evolution of the RSL over the past 2000 years
from integrated sedimentary facies and faunal analyses based on 11 age-dated
sediment cores and investigate the response of mollusc species and
communities to those past environmental changes. Three species associations
(“marine”, “Pontocaspian” and “freshwater”) exist and their spatio-temporal
shifts through the system are documented. Variable salinity gradients
developed, with marine settings (and faunas) dominating in the southern part
of the system and freshwater conditions (and faunas) in the northern and
western parts. Pontocaspian species have mostly occurred in the centre of
the RSL within the marine–freshwater salinity gradient. Today, freshwater
species dominate the entire system, and only a single Pontocaspian species
(Monodacna colorata) is found alive. We show that the human-induced reduced marine influence
in the system has been a major driver of the decline of the endemic
Pontocaspian biota. It urges improved conservation action by
re-establishing a salinity gradient in the lake system to preserve these
unique species.
Meteorological and evaluation datasets for snow modelling at 10 reference sites: description of in situ and bias-corrected reanalysis data
Authors: Ménard Cécile B. , Essery Richard , Barr Alan , Bartlett Paul , Derry Jeff , Dumont Marie , Fierz Charles , Kim Hyungjun , Kontu Anna , Lejeune Yves , Marks Danny , Niwano Masashi , Raleigh Mark , Wang Libo , Wever Nander 
Published: June 2019

Abstract. This paper describes in situ meteorological forcing and evaluation data, and
bias-corrected reanalysis forcing data, for cold regions' modelling at 10
sites. The long-term datasets (one maritime, one arctic, three boreal, and
five mid-latitude alpine) are the reference sites chosen for evaluating
models participating in the Earth System Model-Snow Model Intercomparison
Project. Periods covered by the in situ data vary between 7 and 20 years of hourly meteorological data, with evaluation data (snow depth, snow
water equivalent, albedo, soil temperature, and surface temperature)
available at varying temporal intervals. Thirty-year (1980–2010) time series
have been extracted from a global gridded surface meteorology dataset
(Global Soil Wetness Project Phase 3) for the grid cells containing the
reference sites, interpolated to 1 h time steps and bias-corrected.
Although the correction was applied to all sites, it was most important for
mountain sites hundreds of metres higher than the grid elevations and for
which uncorrected air temperatures were too high and snowfall amounts too
low. The discussion considers the importance of data sharing to the
identification of errors and how the publication of these datasets
contributes to good practice, consistency, and reproducibility in
geosciences. The Supplement provides information on instrumentation,
an estimate of the percentages of missing values, and gap-filling methods at
each site. It is hoped that these datasets will be used as benchmarks for
future model development and that their ease of use and availability will
help model developers quantify model uncertainties and reduce model errors.
The data are published in the repository PANGAEA and are available at
https://doi.pangaea.de/10.1594/PANGAEA.897575.
Birds in Medieval Norway
Authors: Walker Samuel J. , Hufthammer Anne Karin , Meijer Hanneke J. M. 
Published: June 2019

Whilst modern avian distributions in Scandinavia are well studied, how past events and processes have shaped modern bird communities in the region remains poorly known. This is mainly due to the fact that work on post-glacial avian assemblages has been done mostly from an archaeological perspective, and on a site-specific basis. Therefore, in order to understand the history of bird species in Scandinavia, there is a clear need to collate data on the past occurrences and abundance of birds within the region. Here we present data on the presence of bird species within 21 Norwegian Medieval (1030–1537 CE) assemblages. Despite climatic fluctuations and the rise of urban centres, our re-examination and compilation of bird bone assemblages from Medieval Norway found no evidence to suggest that the Medieval bird fauna differed from the modern one. The most common birds in Medieval assemblages are Galliformes. In urban sites these are mostly domestic fowl, whereas on rural sites wild species are dominant. Our data indicates an introduction of domestic fowl in the early Medieval period and a slightly delayed introduction of domestic geese, with both species becoming more abundant during the mid to late Medieval period. This appears to be later than other Scandinavian countries. Interestingly, species that are now ubiquitous in urban areas, such as pigeons, corvids and gulls are mostly absent from Medieval urban centres. In addition, we found a bias towards the use of female Accipiter gentilis in falconry, while Falco species may have been exported. This is the first time that data on past avian occurrences for any period are reviewed and collated for Norway. In addition, our work highlights the importance of birds and bird exploitation in Medieval Norway.
La planeación estratégica y la calidad docente en la Universidad
Authors: Ramírez Gálvez José Roberto 
Published: June 2019

Independientemente del tipo de disciplina o especialidad, las universidades deben formar en sus estudiantes un pensamiento de alto nivel y convertirlos en aprendices autónomos.
Se define enseñanza de calidad como la que consigue alcanzar las metas de enseñanza, mismas que se distinguen por su ambición y complejidad como buscar que los alumnos logren un pensamiento crítico, sean creativos y desarrollen habilidades cognitivas complejas. Sin embargo, de acuerdo con la información disponible, la mayoría de los estudiantes de este nivel no alcanzan esas metas. Se reconoce el papel central que tiene el docente para conseguirlo.
La evaluación educativa y en particular, la del aprendizaje de los estudiantes, constituye en este contexto un tema de singular interés, por su importancia, complejidad y por la vigencia de numerosos problemas pendientes de solución.
La búsqueda de la excelencia en la educación superior es una exigencia actual que compromete a todos aquellos implicados en las tareas educativas y a todos los ámbitos, facetas y componentes del proceso de formación de los futuros profesionales. En nuestro país esa búsqueda se manifiesta en la voluntad de un perfeccionamiento continuo de la enseñanza universitaria sobre bases científicas, que sustenta las decisiones y el quehacer cotidiano de las instituciones educativas e impulsa, a la vez, el desarrollo de la investigación pedagógica como necesidad del propio perfeccionamiento.
La planificación estratégica en una institución de educación superior, es un proceso continuo, técnico-político, sistemático, reflexivo, participativo, crítico y autocrítico, instructivo, flexible, integral y orientador, que promueve el cambio, y precede y preside la acción para la toma de decisiones.
Accuracy of Canine Scent Detection of Non–Small Cell Lung Cancer in Blood Serum
Authors: Junqueira Heather , Quinn Thomas A. , Biringer Roger , Hussein Mohamed , Smeriglio Courtney , Barrueto Luisa , Finizio Jordan , Huang Xi Ying “Michelle” 
Published: June 2019

Abstract

Context
Early detection provides the best opportunity for lung cancer survival; however, lung cancer is difficult to detect early because symptoms do not often appear until later stages. Current screening methods such as x-ray and computed tomographic imaging lack the sensitivity and specificity needed for effective early diagnosis. Dogs have highly developed olfactory systems and may be able to detect cancer in its primary stages. Their scent detection could be used to identify biomarkers associated with various types of lung cancer.

Objective
To determine the accuracy of trained beagles’ ability to use their olfactory system to differentiate the odor of the blood serum of patients with lung cancer from the blood serum of healthy controls.

Methods
Over the course of 8 weeks, operant conditioning via clicker training was used to train dogs to use their olfactory system to distinguish blood serum from patients with malignant lung cancer from blood serum from healthy controls in a double-blind study. After training, non–small cell lung cancer and healthy control blood serum samples were presented to the dogs, and the sensitivity and specificity of each dog were analyzed.

Results
Four dogs were trained for the study, but 1 was unmotivated by training and removed from the study. Three dogs were able to correctly identify the cancer samples with a sensitivity of 96.7%, specificity of 97.5%, positive predictive value of 90.6%, and negative predictive value of 99.2%.

Conclusion
Trained dogs were able to identify non–small cell lung cancer samples from healthy controls. The findings of this study provide a starting point for a larger-scale research project designed to explore the use of canine scent detection as a tool for cancer biomarkers.
Worldwide scientific productions with immunotherapy of sepsis: a bibliometric analysis
Authors: Wan Ronghao , Li Lei , Xing Chenwei , Peng Ronggang , Gao Liang 
Published: June 2019

Background
Sepsis represents a significant healthcare problem worldwide and causes a high number of deaths every year but remains to be fully understood. During and after sepsis, the host immune response is complex and involves an initial excessive host inflammatory response to infection that is closely related to tissue damage and leads to organ failure. Over the past three decades, immunotherapy for sepsis has vastly improved, but in this area, the most influential articles, journals, authors, and countries have not yet been completely summarized and analyzed.

Objective
Performed a bibliometric analysis on all the articles concerning immunotherapy for sepsis from 1962 to 2019 was our objective, and we also explored the potential correlations between publications of different countries and their gross domestic product (GDP).

Methods
All articles about immunotherapy for sepsis were extracted from the Scopus database and analyzed. We also retrieved GDP data from all the countries that have published information from the World Bank.

Results
In summary, we have retrieved 1,483 related articles from the Scopus database starting from the first publication on immunotherapy for sepsis in 1962 through March 16, 2019. Over the past decade, the number of the articles published has increased year by year to reach 866 in total, which accounts for about 58% of all publications, with 2017 being the most prolific year when 179 articles were published. The US published 604 articles (41%), followed by China (n = 163, 11%), and Germany (n = 158, 11%). In terms of publishing media, the journal that published the highest number of the articles was Journal of Critical Care Medicine with 65 articles (4%), followed by Shock with 55 articles (4%), and Critical Care with 35 articles (2%). There was a strong correlation between the GDP of the different countries and their publication numbers (r = 0.811, P < 0.001).

Conclusions
Our present study analyzed all types of articles concerning immunotherapy for sepsis over the past 57 years and countries with high GDP tends to make more contributions to the medical field of this field. In the meantime, these studies highlight the importance of immunotherapy in the treatment of sepsis patients. The recognition of the historical status and development trend of this field can promote inter-agency cooperation, guide future research, and ultimately provide the basis for clinical practice guidelines.
ANALISA ASPEK-ASPEK DALAM PROSEDUR CHANGE ORDER PADA PROYEK KONSTRUKSI
Authors: Kosasi Michael Halmar , Andi Andi , Arijanto Lie 
Published: June 2019

Change order merupakan perubahan kondisi kontrak yang mengubah harga, dan schedule proyek. Penelitian sebelumnya menunjukan claim change order mencapai 50% dari keseluruhan claim, dimana 76% diantaranya merupakan change order lisan dan separuhnya mengalami kegagalan claim. Tujuan penelitian adalah mengetahui berbagai aspek dalam prosedur change order. Metode penelitian yaitu dengan membuat kuesioner berdasarkan literatur terhadap “frekuensi kejadian” dan “tingkat kepentingan”. Data dianalisa deskriptif untuk mendalami kondisi proyek dan literatur beserta penyebabnya secara mendalam, yang kemudian dilakukan analisa perbedaan kontraktor dan MK melalui uji T-Test. Berdasarkan analisa diketahui saat identifikasi, change order diprakarsai owner, kontraktor, MK dengan site instruction, selanjutnya kontraktor harus mengajukan proposal gambar, spesifikasi, harga, dokumentasi. Selanjutnya owner akan mengevaluasi harga satuan dan mengukur volume bersih berdasar perubahan gambar. Pada tahapan approval, owner memberikan tanda tangan berdasarkan harga yang disetujui. Payment dilakukan dengan invoice terpisah sesuai progress change order beserta biaya tidak langsung, sedangkan tambahan waktu diberikan dalam hari kalender

Change orders are changes in contract conditions change prices, and the project schedule. Previous research shows change order claims reaches 50% of total claim, where 76% given in verbal, and half have failed. The research objective is to determine the various aspects of the change order procedure. The research method is to create a questionnaire based on the literature of the "frequency of occurrence" and "level of interest". Data were analyzed descriptively to explore the conditions of the project and literature and how it happens, analyzed the differences contractors and MK through T-Test. Based on the analysis found that identification phase, change orders initiated by the owner, the contractor, MK with site instruction, then the contractor must submit a proposal drawings, specifications, price, documentation. Next phase, owner will evaluate the unit price and measuring the net volume based on changes drawing. At approval phase, owner provides a signature based on the agreed price. Payment is done by a separate invoice based on progress including indirect costs, while additional time is given in calendar days.