bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors influencing the type of self-acceptance in drug addicts and the relationship with subthreshold depression: evidence based on latent profile analysis
Authors: Li Yongqiu , Wang Rufang , Liu Jun , Zhou Yinghua 
Published: December 2024

Abstract

Objective
To study the heterogeneity and influencing factors of self-acceptance of drug addicts in compulsory isolation in 2 drug rehabilitation centers in Sichuan Province, and to analyze the effects of different types of self-acceptance on subthreshold depression in drug addicts, in order to provide useful references for improving their mental health.
Methods
Self-acceptance Questionnaire(SAQ), Drug use Stereotype Threat Scale(DSTS) and Center for Epidemiologic Studies Depression Scale(CES-D) were used to conduct a questionnaire survey in January 2024 on 1068 drug addicts in two compulsory isolation drug rehabilitation centers in Sichuan Province.
Results
Drug addicts self-acceptance can be categorized into 5 potential categories;the results of the multiple logistic regression demonstrated that, males were more likely to exhibit lower self-acceptance than females; drug addicts with an education level of elementary school and below were categorized into the‘low self-acceptance-low self-evaluation’ group ;HIV-negative drug addicts were more likely to show higher self-acceptance than positive patients; the‘low-low’group had the greatest likelihood of being alienated.The results of multiple linear regression showed that drug addicts in the‘ moderate self-appraisal-moderate self-acceptance’group and‘high self-appraisal-high self-acceptance’group had significantly lower subthreshold depression than those in the‘low self-appraisal-low self-acceptance’group;the results of the Kruskal-Wallis Test showed that the‘high self-appraisal-high self-acceptance’group had the lowest level of subthreshold depression, and the‘low self-appraisal-low self-acceptance’,‘low self-appraisal-high self-acceptance’and‘high self-appraisal-low self-acceptance’groups had the highest mean ranks in different dimensions of subthreshold depression.
Conclusion
Heterogeneity exists in drug addicts' self-acceptance, and gender, HIV-positive or not, education level, and drug use stereotype threat are factors influencing self-acceptance in compulsory isolated drug addicts. High self-appraisal-high self-acceptance had the lowest level of subthreshold depression in drug addicts, and the consistency of poor self-appraisal and self-acceptance also affected the level of subthreshold depression in drug addicts.
Design of Infinite Impulse Response Maximally Flat Stable Digital Filter With Low Group Delay
Authors: Yi Huoping , Chang Fuhao , Tan Ping , Huang Bingqiang , Wu Yongbo , Xu Zhen , Ma Bingyu , Ma Jien 
Published: December 2024

Abstract

Maximally flat digital filters (MFDFs) are widely applied in applications where the energy of useful signals is concentrated around some specific frequencies. A typical design method of MFDFs is to impose constraints on the filter’s frequency response and its first- to high-order derivatives at some frequencies and to fully determine the filter coefficients from these constraints. However, infinite impulse response (IIR) MFDFs that are designed by the method are not necessarily stable or may have heavy magnitude overshoots, especially when the desired group delay is low. To overcome this shortcoming, a stability constraint that is characterized by the maximum pole radius is also imposed on the filters in this paper, resulting in IIR maximally flat stable digital filters (MFSDFs). An algorithm is presented for the design of the flatness and pole-radius constrained IIR filters with specified group delay. Using the proposed method, low-pass, high-pass, band-pass and band-stop IIR MFSDFs with low group delay have been designed. Results demonstrate the effectiveness of the proposed method and the superior performance of the IIR MFSDFs over existing MFDFs.
Identification and field validation of QTLs for soybean red crown rot resistance from wild soybean accessions
Authors: Taguchi-Shiobara Fumio , Mimuro Genki , Hishinuma Ai , Kobayashi Michie , Yano Ryoichi , Mizubayashi Tatsumi , Xu Donghe , Kaga Akito , Takahashi Koji , Nanjo Yohei , Jiang Chang-Jie 
Published: December 2024

Abstract

Soybean red crown rot (RCR), a soil-borne disease caused by the fungus Calonectria ilicicola, can lead to annual yield losses of up to 30%. This study identified quantitative trait loci (QTLs) associated with RCR resistance in three wild soybean accessions, ‘Gs-7,’ ‘Gs-9,’ and ‘Gs-27.’ QTL analysis was performed using four populations of recombinant inbred lines (RILs) derived from crossing these wild soybean accessions with two susceptible soybean cultivars ‘Enrei’ (populations En7, En9, and En27, respectively) and ‘Williams 82’ (W9). Genetic linkage maps were constructed using 145–256 simple sequence repeat (SSR) markers for each population, and the RILs were evaluated for RCR resistance in a greenhouse. Consequently, eight QTLs were detected across four regions: qRci1 (En9) and qRci1t (W9) on chromosome 8; qRci2 (En9), qRci2t (En7), and qRci2tw (W9) on chromosome 13; qRci3 (W9) on chromosome 18; qRci4 (En7) and qRci4t (En27) on chromosome 3. Further mapping using residual heterozygous lines localized qRci1 to a 2.52 Mb region between BARCSOYSSR_08_0371 and BARCSOYSSR_08_0507, containing 76 candidate genes. Mapping and QTL-seq analysis suggested that qRci2 was in a 0.90 Mb region downstream of BARCSOYSSR_13_1504, containing 33 candidate genes. Four QTLs—qRci1, qRci2, qRci2t, and qRci4—were backcrossed into ‘Enrei,’ an elite Japanese cultivar, reducing disease severity in both greenhouse and field trials. No epistatic interactions were observed, and two QTLs, qRci2t and qRci4, conferred greater resistance than a single QTL in BC1F4 lines. Thus, pyramiding these QTLs is recommended to confer RCR resistance in commercial soybean cultivars.
Clinical Characteristics and Induced Pluripotent Stem Cells (iPSCs) Disease Model of Harel-Yoon Syndrome Caused by Compound Heterozygous ATAD3A Variants
Authors: Jiang Ziyi , Chen Hongyu , Zhang Xianghong , Jiang Xiaoling , Tong Zhengqing , Ye Jingjing , Shi Shanshan , Shi Xucong , Li Fengxia , Shao Weiqin , Shu Qiang , Yu Lan 
Published: December 2024

Abstract

ATPase family AAA-domain-containing protein 3A (ATAD3A) is enriched on the mitochondrial membrane and is essential to the maintenance of mitochondrial structure and function. Variants of the ATAD3A gene can lead to Harel-Yoon syndrome (HAYOS), a developmental defect in neurological, cardiovascular, and other systems. This study aims to develop induced pluripotent stem cells (iPSCs) from the somatic cells of a patient (ZJUCHYLi001-A) and a negative control (ZJUCHYLi002-A) as effective tools for further investigations into the etiology of ATAD3A variant-related disease. We described and analyzed the clinical manifestations of the proband and her family members. Somatic cells from the proband and a negative control were collected and reprogrammed into iPSCs. Furthermore, we measured the ATAD3A expression levels in the iPSCs to confirm the validity of these cell lines. The proband and her elder sister were both critically ill and harbored compound heterozygous ATAD3A variants (F459S/T498Nfs*13). Their parents were carriers of these variants without any clinical manifestations. Both variants are located on the ATPase domain of the ATAD3A protein. Cell lines ZJUCHYLi001-A and ZJUCHYLi002-A presented typical features of pluripotent stem cells. The ATAD3A expression levels of ZJUCHYLi001-A were significantly reduced compared with ZJUCHYLi002-A. This study generated iPSCs from a patient with compound heterozygous variants of ATAD3A and a negative control as valuable tools for clarifying the molecular mechanisms underlying ATAD3A variant-related diseases.
Holographic inspired high-performance circular polarized spoof surface plasmon polariton leaky-wave antenna excited by a novel launcher
Authors: Zohrevand Sajjad , Zadeh Mohammad Amin Chaychi , Farokhipour Ehsan , Erni Daniel , Komjani Nader 
Published: December 2024

Abstract

The holographic technique is one of the simplest methods for designing antennas based on metasurface. This paper presents a spoof surface plasmon polariton (SSPP) leaky-wave antenna (LWA) based on the concept of impedance modulated metasurfaces by the anisotropic holographic technique. Instead of parasitic elements, anisotropic SSPP elements are exploited to achieve radiation with circular polarization (CP). The characteristics of the SSPP elements are obtained by the aperture field estimate (AFE) method. The hologram surface consists of hollow cross-bars unit cells. The anisotropy of each unit cell is achieved by combining the transformation optic (TO) method and the particle swarm optimization (PSO) algorithm. A major challenge of the SSPP LWA based on modulated impedance surfaces is to find a suitable excitation technique. This study proposes a waveguide strip line launcher for excitation to minimize interference on the radiation pattern beam. The designed launcher provides a good impedance matching from 8 to 20 GHz, with an impedance bandwidth of 142%. The peak gain, radiation efficiency, axial ratio (AR) bandwidth, and side lobe level at the design frequency of 18 GHz are 19.7dBi, 93%, 11%, and − 12.1dB, respectively. After optimizations and simulations are conducted using MATLAB and CST software, the proposed antenna is fabricated, and its radiation characteristics are measured. The measured results agree well with the simulated ones, indicating the high validity of the method.
Computational analysis of antimicrobial peptides targeting key receptors in infection-related cardiovascular diseases: Molecular docking and dynamics insights
Authors: Dermawan Doni , Alotaiq Nasser 
Published: December 2024

Abstract

Infection-related cardiovascular diseases (CVDs) pose a significant health challenge, driving the need for novel therapeutic strategies to target key receptors involved in inflammation and infection. Antimicrobial peptides (AMPs) show the potential to disrupt pathogenic processes and offer a promising approach to CVD treatment. This study investigates the binding potential of selected AMPs with critical receptors implicated in CVDs, aiming to explore their therapeutic potential. A comprehensive computational approach was employed to assess AMP interactions with CVD-related receptors, including ACE2, CRP, MMP9, NLRP3, and TLR4. Molecular docking studies identified AMPs with high binding affinities to these targets, notably Tachystatin, Pleurocidin, and Subtilisin A, which showed strong interactions with ACE2, CRP, and MMP9. Following docking, 100 ns molecular dynamics (MD) simulations confirmed the stability of AMP-receptor complexes, and MM/PBSA calculations provided quantitative insights into binding energies, underscoring the potential of these AMPs to modulate receptor activity in infection and inflammation contexts. The study highlights the therapeutic potential of Tachystatin, Pleurocidin, and Subtilisin A in targeting infection-related pathways in CVDs. These AMPs demonstrate promising receptor binding properties and stability in computational models. Future research should focus on in vitro and in vivo studies to confirm their efficacy and safety, paving the way for potential clinical applications in managing infection-related cardiovascular conditions.
Efficacy and Safety of 360º and 180º Gonioscopy-Assisted Transluminal Trabeculotomy in Combination with Phacoemulsification in Patients with Open-Angle Glaucoma: A Retrospective Case-Control Study.
Authors: Kormas Ran Matlov , Klepfish Eleanor Gafni , Marcovich Arie , Kassem Rabea 
Published: December 2024

Abstract

Purpose: To compare the efficacy and safety of 360º suture gonioscopy-assisted transluminal trabeculotomy (GATT) and 180º GATT (hemi-GATT) combined with cataract surgery in patients with open-angle glaucoma (OAG).
Methods: This single-center retrospective study included patients with OAG treated by GATT or hemi-GATT combined with phacoemulsification with at least six months of follow-up. Outcome measures included change in intraocular pressure (IOP), best-corrected visual acuity (BCVA), and number of glaucoma medications (NGM) used. Success was defined as IOP<18 mmHg with complete reduction of NGM, or IOP<Pre-Op IOP with complete reduction of NGM, or more than 20% IOP reduction with the same or a smaller number of NGM.
Results: Data from 35 patients (mean age=76 years) and 38 treated eyes were included in this study. The procedural success rate with GATT and hemi-GATT was 94% and 91%, respectively. Average IOP reduced from 17.0±4.8 to 12.9±2.7 mmHg in GATT (Δ=-4.2 mmHg, p=0.005) and from 17.8±4.9 to 13.8±3.12 mmHg in hemi-GATT (Δ=-4 mmHg, p=0.002) groups after six months. Average NGM was reduced from 3.5 to 0.3 medications in GATT (Δ=-3.2, p<0.0001) and from 2.5 to 0.5 medications in hemi-GATT (Δ=-2, p<0.0001) after six months. There were no serious adverse events in the two study groups.
Conclusion: GATT and hemi-GATT with concomitant phacoemulsification cataract surgery are equally safe and effective procedures for decreasing IOP and NGM.
Late-night screen time and screen time addiction as shared determinants of poor sleep and obesity in adolescents aged 11-14 years in Scotland
Authors: Gale Emma Louise , Williams Andrew James , Cecil Joanne E 
Published: December 2024

Abstract

Introduction:
The overall quantity of screen time has been associated with short sleep duration and increasingly sedentary lifestyles, leading to adiposity. The aim of this research was to explore which components of screen time usage are shared determinants of poor sleep and higher adiposity in adolescents, using data from the Teen Sleep Well Study (TSWS).
Methods
A cross-sectional study of adolescents aged 11-14-years in Fife, Scotland. Sleep was measured objectively using the Actigraph GT3X-BT and subjectively using validated questionnaires. Adiposity was assessed using body fat percentage and obesity was measured using body mass index percentile (BMIp). Four components of screen time were addressed using questionnaires: the timing of screen time (first and last 30 minutes of the day), quantity of screen time (weekday and weekend, via SCREENS-Q), location of screen time (use of a phone in bed, in the bedroom overnight, as an alarm), and screen time addiction (Videogaming Addiction Questionnaire (VGA-Q), Social Media Addiction Questionnaire (SMA-Q) and Mobile Phone Addiction Questionnaire (MPA-Q)). Descriptive statistics and statistical tests such as Pearson correlation tables, regression analyses and mediation analyses were used. Analyses were adjusted for the demographics of the child participant and caregiver and the wellbeing of the adolescent.
Results
62 participants (33F/29M, mean age 12.2 ± 1.1 years, mean BMI percentile 60.3 ± 32.1) completed the study and were part of the analysis. Excessive late-night and early-morning screen time usage, excessive screen time on a weekend, screen time addiction and using screens in the 30-minutes prior to sleep onset were shared determinants of higher adiposity, a later chronotype and poor sleep regulation outcomes: poor sleep habits, increased insomnia symptoms and increased sleep onset variability. Mediation analyses confirmed that wellbeing of the adolescent was a mediator of the relationship between screen time outcomes and insomnia symptoms and body fat percentage.
Conclusions
These screen time behaviours could be targeted in health-promoting interventions. Further research should assess longitudinal relationships between different components of screen time, sleep and adiposity, when adjusted for wellbeing in adolescents.
Capsule retractors for intraoperative stabilization of the lens during phacoemulsification with weak zonules: a retrospective review
Authors: Kolarov Dobrin , Puk Clemens , Wirbelauer Christopher 
Published: December 2024

Abstract

Purpose
To examine the outcomes of phacoemulsification with capsule retractors in eyes with severe zonular weakness in terms of postoperative stability of the intraocular lens (IOL) and complications.
Methods
All cataract surgeries utilizing capsule retractors in a specialized eye clinic over 6 years were retrospectively reviewed. Predisposing risk factors, the intraoperative technique, the visual acuity, the refractive outcome and position of the IOL were analyzed.
Results
Forty-four surgeries were identified. Postoperative data was available in 36 cases (81.8%) for a mean observation period of 18.3 ± 18.8 months. In 42 cases (95.5%) the surgery was completed with implantation of a capsular tension ring (CTR) and an IOL in the capsular bag. The mean refractive prediction error was 0.04 ± 1.10 D. The mean astigmatism was reduced from − 1.85 ± 1.27 D to -1.52 ± 0.80 D (P = .09). In 15 eyes the IOL was centered and in 10 eyes slightly decentered, in all cases the IOL covered the optical axis. Postoperatively one (2.3%) late dislocation of the IOL and one (2.3%) retinal detachment occurred.
Conclusions
Capsule retractors combined with a CTR are safe and effective for the management of cataract with compromised zonules. The postoperative IOL position and refraction show little clinically significant decentration.
Epigenetic modulation of RIPK3 by Transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis
Authors: Vecchio Alessio , Colasuonno Fiorella , Bellanca Veronica , Pitolli Consuelo , Occhigrossi Luca , Ciccarone Fabio , D'Eletto Manuela , Sano Federica Di , Pagliarini Vittoria , Sette Claudio , Piacentini Mauro , Rossin Federica 
Published: December 2024

Abstract

The receptor interacting protein kinase 3 (RIPK 3) is the main player in the activation of necroptosis, a pro-inflammatory regulated cell death modality induced by many different stimuli. RIPK3 is epigenetically regulated by DNA methylation and can be expressed when its promoter is associated with H3K4me3 histone. In this study, we show that Transglutaminase 2 protein (TG2) is necessary to induce necroptosis pathway allowing the expression of Ripk3 gene. Indeed, cells lacking TG2 show a strong downregulation of Ripk3 gene and are resistant to necroptotic stimuli. TG2 is known to promote the serotonylation of H3K4me3 histone (H3K4me3Q5ser) regulating in this way the target gene expression. Interestingly, we find that TG2 interacts with both histones H3K4me3 and H3K4me3Q5ser and these post-translational modifications are associated with the Ripk3 promoter only in presence of TG2. In addition, the absence of the H3K4me3Q5ser, in cells lacking TG2, is correlated with Ripk3 gene methylation. Altogether, these results indicate that RIPK3 expression requires TG2 mediated serotonylation of H3K4me3 to prevent Ripk3 promoter methylation, thus favouring its expression and necroptosis induction.
Demethylation inhibitor fungicides have a significantly detrimental impact on population growth and community composition of nectar microbial communities
Authors: Quevedo-Caraballo Sergio , Roldán Alejandra , Álvarez-Pérez Sergio 
Published: December 2024

Abstract

Demethylation inhibitor (DMI) fungicides are a mainstay of modern agriculture due to their widespread use for crop protection against plant-pathogenic fungi. However, DMI residues can disperse and persist in the environment, potentially affecting non-target fungi. Previous research has demonstrated that DMIs and other fungicides inhibit yeast growth in floral nectar microbial communities and decrease fungal richness and diversity of exposed flowers with no apparent effect on bacteria. Nevertheless, the effect of DMIs on the population growth of different species of nectar inhabitants and the dynamics of these microbial communities remains understudied. To address these issues, in this study we created synthetic microbial communities including nectar specialist and habitat generalist yeasts and bacteria and propagated them in artificial nectars containing different DMIs (imazalil, propiconazole, and prothioconazole) at different doses or no fungicide. Our results showed that DMIs have a significant impact on nectar microbial populations and favor the growth of bacteria over yeasts. Furthermore, habitat generalists are more impacted by these fungicides than nectar specialists, and the detrimental effect of fungicides on yeast population growth and community composition seems to be amplified upon dispersal across habitat patches. Future research should explore the interaction between growth limitation due to fungicide presence, dispersal limitation, and other mechanisms involved in community assembly in floral nectar.
Alterations in the serum metabolome and proteome of adults after acclimatization to hypoxic environments at different altitudes
Authors: Zhao Jiao , Liu Weili , Wang Xiaoming , Chen Xuewei , Pu Lingling , Wang Zirou , Liu Xiaohua , Wang Xinxing 
Published: December 2024

Abstract

Long-term exposure to high altitudes can induce adaptive or pathological changes in humans; however, the effects of altitude on human serum remain unclear. This study employed untargeted metabolomics and proteomics to examine the differences in serum metabolites and proteins from subjects residing at altitudes of 2900, 3500, 4300, and 4600 m for at least one year compared with those residing in a plain area (altitude of 3 m) under normoxic conditions. The results revealed that long-term high-altitude hypoxia significantly altered human serum metabolites and proteins. Moreover, the pathways of linoleic acid metabolism, arachidonic acid (AA) metabolism, and the complement and coagulation cascades were significantly altered in response to hypoxia. Further analysis revealed that hypoxia at extremely high altitudes (3500–4600 m) promoted the conversion of AA into thromboxane A2, thromboxane B2, 15(S)-hydroxyeicosatetraenoic acid, and 12(S)-hydroxyeicosatetraenoic acid in platelets, resulting in reduced serum AA levels and platelet aggregation. Additionally, the metabolism of AA in platelets further increased with increasing altitude. Exposure to high-altitude areas (2900–4600 meters) increased oxygen transport, glycolysis, coagulation, and inhibits complement activation by increasing the expression of proteins such as globin, glyceraldehyde-3-phosphate dehydrogenase, superoxide dismutase 1, carbonate dehydratase II, and inhibiting complement component 1q. The inhibition of fibrinogen and coagulation factor XI may represent a physiological response to thrombosis and may be associated with liver injury. These findings indicate that high-altitude exposure promotes adaptation to hypoxia by increasing oxygen transport and glycolysis, and promotes thrombosis by interfering with platelet metabolism, and disrupts the complement system by inducing liver damage.
Advancing Thermal Multi-Object Tracking with Attention and Metric Fusion
Authors: Tran Thao-Anh , Le Vu-Minh , Phan Thanh-Tung , Hoang Dung , Phan Duc , Ninh Huong , Tran Hai 
Published: December 2024

Abstract

Multiple-Object Tracking (MOT) is a fundamental task in computer vision with many applications. For practical operations, tracking for monitoring with thermal imaging unaffected by lighting conditions is important. However, most MOT methods are proposed to analyze video streams from RGB cameras, while there are few datasets and research on multi-object tracking in infrared image sequences. In this paper, we provide a new infrared dataset for object detection and tracking, which contains small objects and occlusion challenges. We also propose a new robust tracker, which enhances object detection with the strategic integration of the Convolutional Block Attention Module (CBAM) into the YOLOv7 model, along with specialized fusion of IoU, Size, and ReID features during data association to overcome the challenges of thermal images. Our tracker achieves 59.29 HOTA, 73.46 MOTA, and 74.4 IDF1 as a new state-of-the-art on the CAMEL benchmark. The tracker's source code and dataset are publicly available at: https://github.com/aquarter147/TMTV_Thermal_MOT