bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trend analysis of seasonal rainfall and temperature pattern in Kalahandi, Bolangir and Koraput districts of Odisha, India
Authors: Panda Arpita , Sahu Netrananda 
Published: July 2019

AbstractClimate variability, particularly that of the annual air temperature and rainfall, has received a great deal of attention worldwide. The magnitude of the variability or fluctuations of the factors varies according to locations. Hence, examining the spatiotemporal dynamics of meteorological variables in the context of changing climate, particularly in countries where rainfed agriculture is predominant, is vital to assess climate‐induced changes and suggest feasible adaptation strategies. To that end, the present study examines long‐term changes and short‐term fluctuations in monsoonal rainfall and temperature over Kalahandi, Bolangir and Koraput (hereafter KBK) districts in the state of Odisha. Both rainfall and temperature data for period of 1980–2017 were analyzed in this study. Statistical trend analysis techniques namely Mann–Kendall test and Sen's slope estimator were used to examine and analyze the problems. The detailed analysis of the data for 37 years indicate that the annual maximum temperature and annual minimum temperature have shown an increasing trend, whereas the monsoon's maximum and minimum temperatures have shown a decreasing trend. Statistically significant trends are detected for rainfall and also the result is statistically significant at 99% confidence limit during the period of 1980–2017. Rainfall is showing a quite good increasing trend (Sen's slope = 4.034) for JJAS season. In the case of maximum temperature for the observed period, it showed a slight warming or increasing trend (Sen's slope = 0.29) while the minimum temperature trend showed a cooling trend (Sen's slope = −0.006) but result of maximum temperature trend analysis is statistically significant at 95% confidence limit, on the contrary, the trend analysis result of minimum temperature is not statistically significant.
Are firms with state ownership greener? An institutional complexity view
Authors: Pan Xin , Chen Xuanjin , Sinha Paresha , Dong Niannian 
Published: July 2019

AbstractThis study investigates the role of state ownership in green innovation from the institutional complexity viewpoint. We posit that state ownership can be characterised by two seemingly competing logics: institutional logic, which emphasises that firms with state ownership can acquire resources to promote innovation; and efficiency logic, which states that firms with state ownership have low resource utilisation effectiveness. On the basis of the integration of both views, we suggest a U‐shaped curvilinear relationship between state ownership and green innovation. Data from Chinese listed firms from 2003 to 2015 confirm our hypothesis. Moreover, we also find two macro‐level contingencies that moderate this relationship: regional innovation readiness and industrial competition. The U‐shaped relationship between state ownership and green innovation is more pronounced when regional innovation readiness and industrial competition are higher. This study advances previous research on environmental innovation by arguing that state ownership is characterised by institutional complexity rather than being a monolithic construct.
Clinical conditions and treatment requirements for long‐term survival among hepatitis B‐related hepatocellular carcinoma initially treated with chemoembolization
Authors: Chen Zhen‐Xin , Jian Zhi‐Wei , Wu Xi‐Wen , Wang Jun‐Cheng , Peng Jing‐Yuan , Lao Xiang‐Ming 
Published: July 2019

AbstractObjectiveTransarterial chemoembolization (TACE) is recommended to treat intermediate/advanced stage of hepatocellular carcinoma (HCC). However, the overall survival among initially TACE‐treated patients varies significantly. The clinical characterization of long‐term survival following TACE remains uncertain. We sought to identify clinical parameters and treatment requirements for long‐term survival among patients with hepatitis B‐related HCC who were initially treated with TACE.Materials and MethodsThe included patients with HCC were admitted to our cancer center between December 2009 and May 2015. Patients who survived for >3 years were compared with those who died within 3 years. The clinical and laboratory findings that were associated with the survival were also analyzed.ResultsOne in six (17.9%) patients with HCC in this cohort survived for > 3 years after TACE. Body mass index (BMI) ≥ 23kg/m2, aspartate aminotransferase levels ≤ 40 U/L, an activated partial thromboplastin time ≤ 34 seconds, α‐fetoprotein (AFP) levels ≤ 25 ng/mL, antiviral therapy, tumor size ≤ 8 cm, solitary nodule, and the absence of vascular invasion were independently favorably associated with a 3‐year survival. An absence of vascular invasion was the only independent factor associated with 3‐year survival in patients who received resection and/or ablation after TACE.ConclusionIn this cohort, a 3‐year survival was associated with BMI, antivirus treatment, tumor status, hepatic function, and AFP level. Distant metastasis did not negatively impact the long‐term survival among patients with hepatitis B‐related HCC initially treated with TACE. Vascular invasion was the single impediment to long‐term survival in patients who received add‐on resection and/or ablation after TACE.
Controlling Selectivity in Alkene Oxidation: Anion Driven Epoxidation or Dihydroxylation Catalysed by [Iron(III)(Pyridine‐Containing Ligand)] Complexes
Authors: Tseberlidis Giorgio , Demonti Luca , Pirovano Valentina , Scavini Marco , Cappelli Serena , Rizzato Silvia , Vicente Rubén , Caselli Alessandro 
Published: July 2019

AbstractA highly reactive and selective catalytic system comprising Fe(III) and macrocyclic pyridine‐containing ligands (Pc‐L) for alkene oxidation by using hydrogen peroxide is reported herein. Four new stable iron(III) complexes have been isolated and characterized. Importantly, depending on the anion of the iron(III) metal complex employed as catalyst, a completely reversed selectivity was observed. When X=OTf, a selective dihydroxylation reaction took place. On the other hand, employing X=Cl resulted in the epoxide as the major product. The reaction proved to be quite general, tolerating aromatic and aliphatic alkenes as well as internal or terminal double bonds and both epoxides and diol products were obtained in good yields with good to excellent selectivities (up to 93 % isolated yield and d.r.=99 : 1). The catalytic system proved its robustness by performing several catalytic cycles, without observing catalyst deactivation. The use of acetone as a solvent and hydrogen peroxide as terminal oxidant renders this catalytic system appealing.
Dual Doping Induced Interfacial Engineering of Fe2N/Fe3N Hybrids with Favorable d‐Band towards Efficient Overall Water Splitting
Authors: Hu Yuwen , Huang Duan , Zhang Jingnan , Huang Yongchao , Balogun M.‐Sadeeq Jie Tang , Tong Yexiang 
Published: July 2019

AbstractInterfacial engineering and electronic modulation are some of the main components for enhancing the catalytic activity of electrocatalysts towards achieving efficient water splitting. Iron nitrides exhibit mediocre oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) due to their unsuitable d‐band energy level. In this work, we strongly boost the HER and OER catalytic performance of Fe2N for the first time by doping Co and Al, which could not only induce the formation of Fe2N/Fe3N hybrid interface but also tune the d‐band center position. The CoAl−Fe2N/Fe3N nanoparticles display HER and OER overpotential of 145 and 307 mV at 10 mA/cm2. XPS and DFT calculations confirm that tailoring the d‐band center position and interfacial engineering facilitates strong electronic interactions between Fe2N and Fe3N, synergistically optimize the electronic structure, which enriches H and H2O adsorption energy and oxygen‐containing intermediates. An alkaline electrolyzer based on CoAl−Fe2N/Fe3N requires an overall potential of 1.67 V at 10 mA/cm2, demonstrating the use of iron nitrides as a bifunctional electrocatalyst for water splitting activity.
Phosphorus Post‐Functionalization of Diphosphahexaarenes
Authors: Hindenberg Philip , Rominger Frank , Romero‐Nieto Carlos 
Published: July 2019

AbstractDiphosphahexaarenes are highly stable π‐extended frameworks containing two six‐membered phosphorus heterocycles that have emerged recently. Herein, we present a detailed investigation on the post‐functionalization reactions of their phosphorus centers with special emphasis on the selectivity of the processes and the impact of the phosphorus functionalizations into the physicochemical properties. These studies reveal that indeed the phosphorus atoms of the diphosphahexaarenes are readily available to be functionalized with quaternizing and oxidizing agents as well as borane groups without compromising the stability of the system. In addition, the optoelectronic properties of the diphosphahexaarenes are impacted by the phosphorus post‐modifications.
Pharmacokinetic and Pharmacodynamic Effects of a γ‐Secretase Modulator, PF‐06648671, on CSF Amyloid‐β Peptides in Randomized Phase I Studies
Authors: Ahn Jae Eun , Carrieri Charles , Dela Cruz Fernando , Fullerton Terence , Hajos‐Korcsok Eva , He Ping , Kantaridis Constantino , Leurent Claire , Liu Richann , Mancuso Jessica , Mendes da Costa Laure , Qiu Ruolun 
Published: July 2019

γ‐Secretase modulators (GSMs) represent a promising therapy for Alzheimer's disease by reducing pathogenic amyloid‐β (Aβ) peptide production. Three phase I studies (NCT02316756, NCT02407353, and NCT02440100) investigated the safety/tolerability, pharmacokinetics (PKs), and pharmacodynamics (PDs) of the oral GSM, PF‐06648671. A PK/PD indirect‐response model was developed (using biomarker data) to simultaneously characterize differential effects of PF‐06648671 on multiple Aβ species in cerebrospinal fluid (CSF). Healthy subjects (n = 120) received single doses or multiple‐ascending doses of PF‐06648671/placebo for 14 days. No serious adverse events occurred; severe adverse eventswere deemed not drug related. PF‐06648671 decreased Aβ42 and Aβ40 concentrations in CSF, with greater effects on Aβ42, and increased Aβ37 and Aβ38 levels, particularly Aβ37. No significant change in total Aβ was observed. The PK/PD model well described the tendency of observed CSF Aβ data and the steady‐state effects of PF‐06648671, supporting its use for predicting central Aβ effects and optimal dose selection for GSMs in future trials.
Superior Mesoporosity of Lipid‐Free Spent Coffee Ground Residues
Authors: Dugmore Thomas I. J. , Chen Zhiren , Foster Stella , Peagram Charlie , Matharu Avtar S. 
Published: July 2019

AbstractAs part of the biorefinery concept for spent coffee grounds (SCG), production of activated carbon (AC) was investigated from the degreased coffee grounds (DCG) left behind after oil extraction (primarily for biodiesel). The oils were extracted through conventional solvent extraction with GC/GC–MS confirming the oil was comparable to oils produced industrially. More significantly, analysis showed the DCG AC to have a four‐fold increase in mesoporosity compared with the SCG AC with mesopore volumes of 0.6 and 0.15 cm3 g−1, respectively. Adsorption trials showed a ten‐fold increase in capacity for AuIII from 8.7 to 88.6 mg g−1 with subsequent experiments confirming that DCG AC displayed standard behavior for mesoporous materials of increasing adsorption capacity with decreasing pH. This raises the potential for valorization of SCG into a functional material for water remediation without the need for templating agents or expansion pretreatments with the added bonus of an additional material being produced simultaneously.
Biomimetic Nitrogen Fixation Catalyzed by Transition Metal Sulfide Surfaces in an Electrolytic Cell
Authors: Abghoui Younes , Sigtryggsson Sigtryggur Bjarki , Skúlason Egill 
Published: July 2019

AbstractThe nitrogen reduction reaction was investigated on the surfaces of 18 different stable transition metal sulfides using density functional theory calculations. YS, ScS, and ZrS were modeled in the rocksalt structure with the (1 0 0) facet; TiS, VS, CrS, NbS, NiS, and FeS in NiAs‐type structure with the (1 1 1) facet; and MnS2, CoS2, IrS2, CuS2, OsS2, FeS2, RuS2, RhS2, and NiS2 in pyrite structure for both the (1 0 0) and (1 1 1) orientations. As the first step towards determination of sulfides that are less prone to hydrogen evolution, the competition between adsorption of NNH and H (for the associative mechanism), and between adsorption of N and H (for the dissociative mechanism) on these surfaces was considered. The catalytic activity through both the associative and dissociative mechanisms was explored and the overpotential required for electrochemical ammonia formation is reported. The scaling relations and volcano plots were constructed with free energy of adsorption of NNH or N on the surface as the descriptor. RuS2 was observed as the most active sulfide that could catalyze nitrogen reduction to ammonia at potentials around −0.3 V through the associative mechanism. NbS, CrS, TiS, and VS are also promising candidates for both the associative and dissociative mechanisms with overpotentials for nitrogen reduction around 0.7–1.1 V.
Dual symbol optimization‐based partial transmit sequence technique for PAPR reduction in WOLA‐OFDM waveform
Authors: Taşpınar Necmi , Şimşir Şakir 
Published: July 2019

SummaryWeighted overlap and add‐orthogonal frequency division multiplexing (WOLA‐OFDM) is a new waveform proposed recently for meeting the requirements of fifth generation (5G) telecommunication standards. In spite of being a serious 5G waveform candidate, WOLA‐OFDM is exposed to the problem of high peak to average power ratio (PAPR) similar to the other waveforms in which multicarrier transmission strategy is employed. Due to the overlapping nature of WOLA‐OFDM waveform, where the extension of the current symbol is overlapped with the extension of the previous symbol, it will not be efficient to apply conventional PTS (C‐PTS) directly to the WOLA‐OFDM waveform. Therefore, in this paper, we propose dual symbol optimization‐based partial transmit sequence (DSO‐PTS) technique for PAPR reduction in WOLA‐OFDM waveform. In our proposed technique, two adjacent symbols are jointly considered when searching for the optimal data block with minimum PAPR unlike the C‐PTS where the adjacent symbols are optimized individually. In the simulations, our proposed DSO‐PTS technique, C‐PTS, and GreenOFDM that is developed recently by modifying the conventional selective mapping (SLM) method are compared with each other with regard to PAPR reduction performance for different search numbers (SNs). In addition, the effects of DSO‐PTS, C‐PTS, and GreenOFDM on the amount of out of band (OOB) radiation in the power spectral density (PSD) graph of WOLA‐OFDM employing solid state power amplifier (SSPA) is measured for different SNs and input back off (IBO) values. According to the simulation results, our proposed DSO‐PTS technique clearly demonstrates a superior PAPR reduction and PSD performance.
Novel tag estimation method by use of Manchester coding in RFID systems
Authors: HajMirzaei Milad 
Published: July 2019

SummaryRadio frequency identification suffers from tag collision issue. ALOHA‐based algorithms are useful and practical groups of tag anti‐collision algorithm among others. Some standards such as EPCglobal Class‐1 Generation‐2 use some kind of dynamic framed slotted ALOHA (DFSA) to cope with tag collision. DFSA efficiency depends on estimating the number of unidentified tags in each identification cycle accurately. So tag estimation is one of the challenging issues in DFSA. In this paper, we use Manchester coding to compute the lower bound of collided tags in a frame and then add α as an additional value to computed value according to the difference between optimal number of collision slots and calculated number of collision slots. Then, we evaluate and compare our method with other proposed methods.
Application of the Milan System for Reporting Salivary Gland Cytopathology: A retrospective study in a tertiary institute
Authors: Chen Yun‐An , Wu Chih‐Ying , Yang Chi‐Shun 
Published: July 2019

AbstractBackgroundFine needle aspiration (FNA) cytology has been widely used in the preoperative evaluation of salivary gland lesions. The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is a tiered risk‐stratification scheme designed to standardize reporting and facilitate decision making. We aimed to clarify the validity and diagnostic utility of the MSRSGC‐based classification of salivary gland lesions.MethodsA total of 1020 salivary gland FNA specimens were retrieved between 2008 and 2017, with histologic follow‐up data available for 349 specimens. Within the present retrospective study, each specimen with follow‐up data was reclassified according to the MSRSGC diagnostic categories: nondiagnostic, nonneoplastic, atypia of undetermined significance (AUS), benign neoplasm, salivary gland neoplasm of uncertain malignant potential (SUMP), suspicious for malignancy (SM), and malignant. The risk of malignancy (ROM) was calculated based on the histologic follow‐up data.ResultsThe diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of the MSRSGC‐based classification of the malignant potential of salivary gland lesions were 80.1%, 70.4%, 99.2%, 90.5%, and 96.7%, respectively. The ROM calculated for specimens assigned to the nondiagnostic, nonneoplastic, AUS, benign neoplasm, SUMP, SM, and malignant categories were 8.6%, 15.4%, 36.8%, 2.6%, 32.3%, 71.4%, and 100%, respectively.ConclusionThe present results confirm the validity and diagnostic utility of MSRSGC, supporting its use in clinical practice to help devise adequate management strategies for salivary gland lesions.
The protective effect of syringic acid on dextran sulfate sodium‐induced experimental colitis in BALB/c mice
Authors: Fang Wenhui , Zhu Shihong , Niu Zhongbao , Yin Yuti 
Published: July 2019

AbstractInflammatory bowel diseases involve chronic intestinal inflammation which is mostly caused by Crohn's disease and ulcerative colitis (UC) conditions. Patients having UC are prone to colorectal cancer and dysplastic polyps, and also have sporadic adenomas. Syringic acid (SA) possesses many health benefits including antioxidant, anti‐bacterial, and anti‐cancer. This study was aimed to identify the effects of SA on UC, using a murine experimental model. Clinical symptoms and weight loss were significantly reduced in mice induced with dextran sulfate sodium (DSS) and treated with SA, compared to untreated mice. The effects of SA exhibited in DSS‐induced mice were associated with significant decrease in the expressions levels of inflammatory mediators such as inducible nitric oxide synthase (iNOS), cyclooxygenase‐2 (COX‐2), pro‐inflammatory cytokines (tumor necrosis factor [TNF‐α], interleukin [IL‐1β and IL‐6]), remarkable amelioration of colonic architectural disruption, and a significant reduction in the activity of colonic myeloperoxidase. To further confirm the anti‐inflammatory property of SA, RAW 264.7 cells were stimulated with lipopolysaccharides. SA dose‐dependently inhibited the cytokines TNF‐α, IL‐1β, and IL‐6. It also decreased the expressions of p65‐NF‐κB and IκB, thus reducing the activation and nuclear accumulation of p‐STAT‐3Y705. This prohibited the degradation of inhibitory protein, IκB, as well as inhibited the nuclear translocation of p65‐NF‐κB in colonic tissue. It was concluded that SA has a potential to limit inflammation via inhibiting the p65‐NF‐κB and STAT3 signaling; hence it can be used for therapeutic purposes.
Generation and characterization of Lhx4tdT reporter knock‐in and Lhx4loxP conditional knockout mice
Authors: Dong Xuhui , Xie Xiaoling , Guo Luming , Xu Jiadong , Xu Mei , Liang Guoqing , Gan Lin 
Published: July 2019

SummaryLHX4 is a LIM‐homeodomain transcription factor essential for the development of spinal cord and pituitary gland. Mice with homozygous Lhx4‐null mutation suffer early postnatal death from lung defect. In this study, to facilitate the research on Lhx4 function, we designed a targeting construct to generate two novel Lhx4 mouse lines: Lhx4
loxP conditional knockout and Lhx4
tdT reporter knock‐in mice. Lhx4
tdT/+, Lhx4
loxP/+, and Lhx4
loxP/loxP were viable, fertile, and did not display any gross abnormalities. By breeding Lhx4
loxP line with Cre‐expressing mice, the Exon 3 of Lhx4 was efficiently removed, resulting in a shift in the reading frame and the inactivation of Lhx4. The expression of tdTomato knock‐in reporter recapitulated the endogenous LHX4 expression and was detected in the retina, spinal cord, pituitary gland, and hindbrain of Lhx4
tdT mice. Thus, Lhx4
tdT and Lhx4
loxP mouse lines provide valuable tools for unraveling the tissue‐specific role of Lhx4 at postnatal stages in mice.
Re‐conceptualization of anorexia nervosa psychopathology: A network analysis study in adolescents with short duration of the illness
Authors: Monteleone Alessio Maria , Mereu Alberta , Cascino Giammarco , Criscuolo Michela , Castiglioni Maria Chiara , Pellegrino Francesca , Patriciello Giuseppina , Ruzzi Valeria , Monteleone Palmiero , Vicari Stefano , Zanna Valeria 
Published: July 2019

AbstractObjectiveResearch evidence suggests the need to identify treatments based on a more precise characterization of psychopathology and psychiatric comorbidity in anorexia nervosa. Network analysis provides a new method to conceptualize psychopathology. We use this approach to investigate the relationships between eating disorder and general psychiatric symptoms in adolescents with anorexia nervosa.MethodsFour‐hundred and five adolescents with anorexia nervosa and illness duration less than 3 years were consecutively recruited from those admitted to inpatient treatment. They completed the following questionnaires: the Eating Disorder Inventory‐3, the Multidimensional Anxiety Scale for Children, the Children's Depression Inventory, and the Youth Self Report. A network analysis was conducted, including eating psychopathology measures, anxiety and depressive symptoms, and obsessive–compulsive and post‐traumatic stress problems. We employ a novel approach, the bridge function, to identify symptom clusters.ResultsDepression symptoms and personal alienation were the nodes with the highest centrality in the network, followed by asceticism, post‐traumatic stress problems, drive to thinness, low self‐esteem, and anxiety physical symptoms. Three symptom clusters (relative to eating disorder psychopathology, self‐esteem problems, and internalizing difficulties) were identified. Depression symptoms, personal alienation, low self‐esteem, and interoceptive deficits showed the highest bridge centrality. Besides eating disorder core symptoms, negative affect and internalizing symptoms seem to contribute to anorexia nervosa psychopathology independently from illness duration effects.DiscussionThese findings suggest that anorexia nervosa is characterized by a broad psychopathological spectrum rather than the mere eating disorder core symptoms, confirm the need to re‐conceptualize psychiatric comorbidity in this disorder, and provide intriguing diagnostic and therapeutic implications.