bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuromuscular electrical stimulation‐promoted plasticity of the human brain
Authors: Carson Richard G. , Buick Alison R. 
Published: September 2019

AbstractThe application of neuromuscular electrical stimulation (NMES) to paretic limbs has demonstrated utility for motor rehabilitation following brain injury. When NMES is delivered to a mixed peripheral nerve, typically both efferent and afferent fibres are recruited. Muscle contractions brought about by the excitation of motor neurons are often used to compensate for disability by assisting actions such as the formation of hand aperture, or by preventing others including foot drop. In this context, exogenous stimulation provides a direct substitute for endogenous neural drive. The goal of the present narrative review is to describe the means through which NMES may also promote sustained adaptations within central motor pathways, leading ultimately to increases in (intrinsic) functional capacity. There is an obvious practical motivation, in that detailed knowledge concerning the mechanisms of adaptation has the potential to inform neurorehabilitation practice. In addition, responses to NMES provide a means of studying CNS plasticity at a systems level in humans. We summarize the fundamental aspects of NMES, focusing on the forms that are employed most commonly in clinical and experimental practice. Specific attention is devoted to adjuvant techniques that further promote adaptive responses to NMES thereby offering the prospect of increased therapeutic potential. The emergent theme is that an association with centrally initiated neural activity, whether this is generated in the context of NMES triggered by efferent drive or via indirect methods such as mental imagery, may in some circumstances promote the physiological changes that can be induced through peripheral electrical stimulation.
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Structural Assessment of Large Membrane Structures Using an Unmanned Aerial Vehicle Aided Photogrammetry: Determination of Flight Parameters and Trials at the Western Treatment Plant
Authors: Wong Leslie , Courtney Frank , Vien Benjamin Steven , Kuen Thomas , Douglas Peter , Ma Yue , Kodikara Jayantha , Chiu Wing Kong 
Published: September 2019

Abstract
Floating covers are examples of a large membrane structure used at sewage treatment plants. At the Western Treatment Plant (WTP), Werribee, Melbourne, Australia, floating covers are used in the anaerobic lagoons. They are deployed to assist with the anaerobic treatment of the raw sewage beneath, to harness the methane-rich biogas generated, and for odor control. In this respect, these floating covers are important assets for harnessing a sustainable and renewable energy source, as well as protecting the environment from the release of the damaging greenhouse methane-rich biogas from the treatment plant. Given the continuous nature of the biological process beneath the cover, the forces imposed on the floating cover will change with time. Hence, the monitoring and the assessment of the structural integrity of the floating cover are of paramount importance. These floating covers are made from high-density polyethylene (HDPE), a polymeric material. The size of these covers, the hazardous environment, and the expected life span demand a novel, remotely piloted, unmanned aerial vehicle based noncontact technique for the structural health assessment. This assessment methodology will utilize photogrammetry as the basis for determining the surface deformation of the membrane. This paper reports on an experimental study to determine the flight parameters and to assess the accuracy of the measurement technique. It was conducted over an area having similar dimensions to the large covers at the WTP. There are also features in this area, which are of similar scale to those expected in the floating cover. A total of nine test flights were used to investigate the parameters for optimal definition of the significant features to describe the deformation of the floating cover. The findings inform the selection of the unmanned aerial vehicle assisted photogrammetry parameters for optimal flight altitude, photogrammetry image overlap, and flight grid path for future integrity assessment of the floating covers. Two trial flights at WTP are also discussed to demonstrate the effectiveness of this noncontact technique for the future structural health assessment and in assisting with the operation of this large high-value asset.
Analysis of gastric and duodenal biopsy results in patients presenting with dyspepsia: a cross-sectional study in a middle eastern population
Authors: Ghosn Youssef , Hussein Kamareddine Mohammed , Tawk Antonios , Bou-Ayash Naseem , Bou-Ayash Haneen , Mokamer Nader , Yared Rawad , Aoun Mouna , Khoury Salem , Cortas George , Jabbour Gide , Bedran Khalil , Farhat Said 
Published: September 2019

ObjectiveCorrea’s cascade is a ‘Model for Gastric Cancer Development’ described by Peleyo Correa. The reversibility of Correa’s cascade remains debatable. The literature contains insufficient data on the specific stage of the cascade during whichHelicobacterpyloriis detected, treated, and the effect on prognosis. Herein, we aim to determine the prevalence of various precancerous and cancerous gastric lesions in patients presenting with dyspepsia, the prevalence of gastritis andH. pyloriinfection, the prevalence of duodenal pathology in patients presenting with dyspepsia, identify the stage ofH. pyloridetection in relation to Correa’s cascade, and investigate a possible relationship betweenH. pyloriand celiac disease.DesignRetrospective cross-sectional study conducted on a middle eastern population at a Lebanese tertiary hospital centre. 1428 patients presenting with dyspepsia underwent gastroscopy with gastric and duodenal biopsies. Variables include age, sex, presence/absence ofH. pyloriinfection, and histopathological analysis of gastric and duodenal biopsies.ResultsBeing above 40 years of age was associated with increased likelihood of exhibiting abnormal gastric biopsy result. Gastritis and metaplasia were detected more frequently than glandular atrophy (p<0.001) with gastritis being present the most (p<0.001). The presence ofH. pyloriand the gastric biopsy results were not associated with any of the duodenal biopsy results.ConclusionThe burden ofH. pyloriinfection in patients with dyspepsia was high.H. pyloriwas detected at various precancerous lesions with varying significance. The prevalence of duodenal adenocarcinoma in dyspeptic patients is unexpectedly high. No association between gastric and duodenal pathologies was found.
Reporting and interpretation of results from clinical trials that did not claim a treatment difference: survey of four general medical journals
Authors: Gates Simon , Ealing Elizabeth 
Published: September 2019

ObjectivesTo describe and summarise how the results of randomised controlled trials (RCTs) that did not find a significant treatment effect are reported, and to estimate how commonly trial reports make unwarranted claims.DesignWe performed a retrospective survey of published RCTs, published in four high impact factor general medical journals between June 2016 and June 2017.SettingTrials conducted in all settings were included.Participants94 reports of RCTs that did not find a difference in their main comparison or comparisons were included.InterventionsAll interventions.Primary and secondary outcomesWe recorded the way the results of each trial for its primary outcome or outcomes were described in Results and Conclusions sections of the Abstract, using a 10-category classification. Other outcomes were whether confidence intervals (CIs) and p values were presented for the main treatment comparisons, and whether the results and conclusions referred to measures of uncertainty. We estimated the proportion of papers that made claims that were not justified by the results, or were open to multiple interpretations.Results94 trial reports (120 treatment comparisons) were included. In Results sections, for 58/120 comparisons (48.3%) the results of the study were re-stated, without interpretation, and 38/120 (31.7%) stated that there was no statistically significant difference. In Conclusions, 65/120 treatment comparisons (54.2%) stated that there was no treatment benefit, 14/120 (11.7%) that there was no significant benefit and 16/120 (13.3%) that there was no significant difference. CIs and p values were both presented by 84% of studies (79/94), but only 3/94 studies referred to uncertainty when drawing conclusions.ConclusionsThe majority of trials (54.2%) inappropriately interpreted a result that was not statistically significant as indicating no treatment benefit. Very few studies interpreted the result as indicating a lack of evidence against the null hypothesis of zero difference between the trial arms.
Changes in job satisfaction among doctors in Norway from 2010 to 2017: a study based on repeated surveys
Authors: Rosta Judith , Aasland Olaf G , Nylenna Magne 
Published: September 2019

ObjectiveTo assess job satisfaction for different categories of Norwegian doctors from 2010 to 2016–2017.DesignCross-sectional surveys in 2010, 2012, 2014 and 2016–2017 of partly overlapping samples.SettingNorway from 2010 to 2016–2017.ParticipantsDoctors working in different job positions (hospital doctors, general practitioners (GPs), private practice specialists, doctors in academia). Response rates were 67% (1014/1520) in 2010, 71% (1279/1792) in 2012, 75% (1158/1545) in 2014 and 73% (1604/2195) in 2016–2017. The same 548 doctors responded at all four points in time.Main outcome measureJob Satisfaction Scale (JSS), a 10-item widely used instrument, with scores ranging from 1 (low satisfaction) to 7 (high satisfaction) for each item, and an unweighted mean total sum score.AnalysisGeneral Linear Modelling, controlling for gender and age, and paired t-tests.ResultsFor all doctors, the mean scores of JSS decreased significantly from 5.52 (95% CI 5.42 to 5.61) in 2010 to 5.30 (5.22 to 5.38) in 2016–2017. The decrease was significant for GPs (5.54, 5.43 to 5.65 vs 5.17, 5.07 to 5.28) and hospital doctors (5.14, 5.07 to 5.21 vs 5.00, 4.94 to 5.06). Private practice specialists were most satisfied, followed by GPs and hospital doctors. The difference between the GPs and the private practice specialists increased over time.ConclusionsFrom 2010 to 2016–2017 job satisfaction for Norwegian doctors decreased, but it was still at a relatively high level. Several healthcare reforms and regulations over the last decade and changes in the professional culture may explain some of the reduced satisfaction.
Efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases: a systematic literature review for the 2019 update of EULAR recommendations
Authors: Rondaan Christien , Furer Victoria , Heijstek Marloes W , Agmon-Levin Nancy , Bijl Marc , Breedveld Ferdinand C , D’Amelio Raffaele , Dougados Maxime , Kapetanovic Meliha C , van Laar Jacob M , Ladefoged de Thurah Annette , Landewé Robert , Molto Anna , Müller-Ladner Ulf , Schreiber Karen , Smolar Leo , Walker Jim , Warnatz Klaus , Wulffraat Nico M , van Assen Sander , Elkayam Ori 
Published: September 2019

AimTo present a systematic literature review (SLR) on efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD), aiming to provide a basis for updating the EULAR evidence-based recommendations.MethodsAn SLR was performed according to the standard operating procedures for EULAR-endorsed recommendations. Outcome was determined by efficacy, immunogenicity and safety of vaccination in adult patients with AIIRD, including those receiving immunomodulating therapy. Furthermore, a search was performed on the effect of vaccinating household members of patients with AIIRD on the occurrence of vaccine-preventable infections in patients and their household members (including newborns). The literature search was performed using Medline, Embase and the Cochrane Library (October 2009 to August 2018).ResultsWhile most investigated vaccines were efficacious and/or immunogenic in patients with AIIRD, some were less efficacious than in healthy control subjects, and/or in patients receiving immunosuppressive agents. Adverse events of vaccination were generally mild and the rates were comparable to those in healthy persons. Vaccination did not seem to lead to an increase in activity of the underlying AIIRD, but insufficient power of most studies precluded arriving at definite conclusions. The number of studies investigating clinical efficacy of vaccination is still limited. No studies on the effect of vaccinating household members of patients with AIIRD were retrieved.ConclusionEvidence on efficacy, immunogenicity and safety of vaccination in patients with AIIRD was systematically reviewed to provide a basis for updated recommendations.
Quotients of del Pezzo surfaces
Authors: Trepalin Andrey 
Published: September 2019

Let [Formula: see text] be any field of characteristic zero, [Formula: see text] be a del Pezzo surface and [Formula: see text] be a finite subgroup in [Formula: see text]. In this paper, we study when the quotient surface [Formula: see text] can be non-rational over [Formula: see text]. Obviously, if there are no smooth [Formula: see text]-points on [Formula: see text] then it is not [Formula: see text]-rational. Therefore, under assumption that the set of smooth [Formula: see text]-points on [Formula: see text] is not empty we show that there are few possibilities for non-[Formula: see text]-rational quotients. The quotients of del Pezzo surfaces of degree [Formula: see text] and greater are considered in the author’s previous papers. In this paper, we study the quotients of del Pezzo surfaces of degree [Formula: see text]. We show that they can be non-[Formula: see text]-rational only for the trivial group or cyclic groups of order [Formula: see text], [Formula: see text] and [Formula: see text]. For the trivial group and the group of order [Formula: see text], we show that both [Formula: see text] and [Formula: see text] are not [Formula: see text]-rational if the [Formula: see text]-invariant Picard number of [Formula: see text] is [Formula: see text]. For the groups of order [Formula: see text] and [Formula: see text], we construct examples of both [Formula: see text]-rational and non-[Formula: see text]-rational quotients of both [Formula: see text]-rational and non-[Formula: see text]-rational del Pezzo surfaces of degree [Formula: see text] such that the [Formula: see text]-invariant Picard number of [Formula: see text] is [Formula: see text]. As a result of complete classification of non-[Formula: see text]-rational quotients of del Pezzo surfaces we classify surfaces that are birationally equivalent to quotients of [Formula: see text]-rational surfaces, and obtain some corollaries concerning fields of invariants of [Formula: see text].
Quark degrees of freedom and nuclear matter saturation
Authors: Baldo Marcello , Aghbolaghi Zahra Asadi , Vidaña Isaac , Bigdeli Mohsen 
Published: September 2019

It has been found in previous works [M. Baldo and K. Fukukawa, Phys. Rev. Lett. 113, 241501 (2014); K. Fukukawa, M. Baldo, G. F. Burgio, L. Lo Monaco and H.-J. Schulze, Phys. Rev. 92, 065802 (2015)] that the nucleon–nucleon potential of [Y. Fujiwara, M. Kohno, C. Nakamoto and Y. Suzuki Phys. Rev. C 64, 054001 (2001); Y. Fujiwara et al., Phys. Rev. C 65, 014002 (2001)] gives an accurate saturation point in symmetric nuclear matter once the three hole-line contributions are included in the Brueckner–Bethe–Goldstone expansion without the addition of three-body forces in the nuclear Hamiltonian. The potential is based on a quark model of nucleons and on the quark–quark interaction together with quark exchange processes. These features introduce an intrinsic nonlocality of the nucleon–nucleon interaction. In order to clarify the role of the quark degrees of freedom and of the nonlocality in the saturation, we perform a comparative study of this potential and the traditional meson exchange models, exemplified in the CD-Bonn potential. We find that at the Brueckner–Hartree–Fock approximation, which corresponds to the two hole-line level of approximation, the dominant modification of the nucleon–nucleon interaction with respect to CD-Bonn is incorporated in the s-wave channels, where the quark degrees of freedom should be more relevant, in particular for the short range quark exchange processes. However, when the three hole-line contribution is included, we find that the higher partial waves play a relevant role, mainly in the term that describes the effect of the medium on the off-shell propagation of the nucleon.
Problematic Roadmapping for Companies in Less Developed Regions of Slovakia
Authors: Jemala Marek 
Published: September 2019

This economic research was based on the literary analysis, various empirical studies and statistical versus qualitative research in 500 problematic companies mainly in the East of Slovakia. Businesses received about 100 questions about innovation management, innovation support, strategic planning, roadmapping, risk management, etc. These statistical results were completed by the expert consultations in 2018–2019. Based on the research results, it can be concluded that these problematic companies are mainly micro-companies with up to 10 employees (mostly Ltd.), mainly in the construction, engineering, automotive, rubber, and plastic industries. These companies are dominated by piece and series production. The use of RM processes was minimal and only applied in larger companies (TR ≥ 500 000 €). The roadmapping processes have been greatly simplified and unsystematic, mainly based on the requirements of business owners or top managers.
(1,0)-Relaxed strong edge list coloring of planar graphs with girth 6
Authors: Lin Kai , Chen Min , Chen Dong 
Published: September 2019

Let [Formula: see text] be a graph. An [Formula: see text]-relaxed strong edge [Formula: see text]-coloring is a mapping [Formula: see text] such that for any edge [Formula: see text], there are at most [Formula: see text] edges adjacent to [Formula: see text] and [Formula: see text] edges which are distance two apart from [Formula: see text] assigned the same color as [Formula: see text]. The [Formula: see text]-relaxed strong chromatic index, denoted by [Formula: see text], is the minimum number [Formula: see text] of an [Formula: see text]-relaxed strong [Formula: see text]-edge-coloring admitted by [Formula: see text]. [Formula: see text] is called [Formula: see text]-relaxed strong edge [Formula: see text]-colorable if for a given list assignment [Formula: see text], there exists an [Formula: see text]-relaxed strong edge coloring [Formula: see text] of [Formula: see text] such that [Formula: see text] for all [Formula: see text]. If [Formula: see text] is [Formula: see text]-relaxed strong edge [Formula: see text]-colorable for any list assignment with [Formula: see text] for all [Formula: see text], then [Formula: see text] is said to be [Formula: see text]-relaxed strong edge [Formula: see text]-choosable. The [Formula: see text]-relaxed strong list chromatic index, denoted by [Formula: see text], is defined to be the smallest integer [Formula: see text] such that [Formula: see text] is [Formula: see text]-relaxed strong edge [Formula: see text]-choosable. In this paper, we prove that every planar graph [Formula: see text] with girth 6 satisfies that [Formula: see text]. This strengthens a result which says that every planar graph [Formula: see text] with girth 7 and [Formula: see text] satisfies that [Formula: see text].
Automated Detection of Intracranial Large Vessel Occlusions on Computed Tomography Angiography
Authors: Amukotuwa Shalini A. , Straka Matus , Smith Heather , Chandra Ronil V. , Dehkharghani Seena , Fischbein Nancy J. , Bammer Roland 
Published: September 2019

Background and Purpose—
Endovascular thrombectomy is highly effective in acute ischemic stroke patients with an anterior circulation large vessel occlusion (LVO), decreasing morbidity and mortality. Accurate and prompt identification of LVOs is imperative because these patients have large volumes of tissue that are at risk of infarction without timely reperfusion, and the treatment window is limited to 24 hours. We assessed the accuracy and speed of a commercially available fully automated LVO-detection tool in a cohort of patients presenting to a regional hospital with suspected stroke.

Methods—
Consecutive patients who underwent multimodal computed tomography with thin-slice computed tomography angiography between January 1, 2017 and December 31, 2018 for suspected acute ischemic stroke within 24 hours of onset were retrospectively identified. The multimodal computed tomographies were assessed by 2 neuroradiologists in consensus for the presence of an intracranial anterior circulation LVO or M2-segment middle cerebral artery occlusion (the reference standard). The patients’ computed tomography angiographies were then processed using an automated LVO-detection algorithm (RAPID CTA). Receiver-operating characteristic analysis was used to determine sensitivity, specificity, and negative predictive value of the algorithm for detection of (1) an LVO and (2) either an LVO or M2-segment middle cerebral artery occlusion.

Results—
CTAs from 477 patients were analyzed (271 men and 206 women; median age, 71; IQR, 60–80). Median processing time was 158 seconds (IQR, 150–167 seconds). Seventy-eight patients had an anterior circulation LVO, and 28 had an isolated M2-segment middle cerebral artery occlusion. The sensitivity, negative predictive value, and specificity were 0.94, 0.98, and 0.76, respectively for detection of an intracranial LVO and 0.92, 0.97, and 0.81, respectively for detection of either an intracranial LVO or M2-segment middle cerebral artery occlusion.

Conclusions—
The fully automated algorithm had very high sensitivity and negative predictive value for LVO detection with fast processing times, suggesting that it can be used in the emergent setting as a screening tool to alert radiologists and expedite formal diagnosis.