bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8+ Tumor-Infiltrating T Lymphocyte Responses
Authors: Abd Hamid Megat , Wang Ruo-Zheng , Yao Xuan , Fan Peiwen , Li Xi , Chang Xue-Mei , Feng Yaning , Jones Stephanie , Maldonado-Perez David , Waugh Craig , Verrill Clare , Simmons Alison , Cerundolo Vincenzo , McMichael Andrew , Conlon Christopher , Wang Xiyan , Peng Yanchun , Dong Tao 
Published: June 2019

AbstractImmunotherapy treatments with anti-PD-1 boost recovery in less than 30% of treated cancer patients, indicating the complexity of the tumor microenvironment. Expression of HLA-E is linked to poor clinical outcomes in mice and human patients. However, the contributions to immune evasion of HLA-E, a ligand for the inhibitory CD94/NKG2A receptor, when expressed on tumors, compared with adjacent tissue and peripheral blood mononuclear cells, remains unclear. In this study, we report that epithelial-derived cancer cells, tumor macrophages, and CD141+ conventional dendritic cells (cDC) contributed to HLA-E enrichment in carcinomas. Different cancer types showed a similar pattern of enrichment. Enrichment correlated to NKG2A upregulation on CD8+ tumor-infiltrating T lymphocytes (TIL) but not on CD4+ TILs. CD94/NKG2A is exclusively expressed on PD-1high TILs while lacking intratumoral CD103 expression. We also found that the presence of CD94/NKG2A on human tumor–specific T cells impairs IL2 receptor–dependent proliferation, which affects IFNγ-mediated responses and antitumor cytotoxicity. These functionalities recover following antibody-mediated blockade in vitro and ex vivo. Our results suggest that enriched HLA-E:CD94/NKG2A inhibitory interaction can impair survival of PD-1high TILs in the tumor microenvironment.
Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development
Authors: Gui Xun , Deng Mi , Song Hao , Chen Yuanzhi , Xie Jingjing , Li Zunling , He Licai , Huang Fangfang , Xu Yixiang , Anami Yasuaki , Yu Hai , Yu Chenyi , Li Leike , Yuan Zihao , Xu Xiaoying , Wang Qihui , Chai Yan , Huang Tao , Shi Yi , Tsuchikama Kyoji , Liao X. Charlene , Xia Ningshao , Gao George F. , Zhang Ningyan , Zhang Cheng Cheng , An Zhiqiang 
Published: June 2019

AbstractTherapeutic strategies are urgently needed for patients with acute myeloid leukemia (AML). Leukocyte immunoglobulin-like receptor B4 (LILRB4), which suppresses T-cell activation and supports tissue infiltration of AML cells, represents an attractive drug target for anti-AML therapeutics. Here, we report the identification and development of an LILRB4-specific humanized mAb that blocks LILRB4 activation. This mAb, h128-3, showed potent activity in blocking the development of monocytic AML in various models including patient-derived xenograft mice and syngeneic immunocompetent AML mice. MAb h128-3 enhanced the anti-AML efficacy of chemotherapy treatment by stimulating mobilization of leukemia cells. Mechanistic studies revealed four concordant modes of action for the anti-AML activity of h128-3: (i) reversal of T-cell suppression, (ii) inhibition of monocytic AML cell tissue infiltration, (iii) antibody-dependent cellular cytotoxicity, and (iv) antibody-dependent cellular phagocytosis. Therefore, targeting LILRB4 with antibody represents an effective therapeutic strategy for treating monocytic AML.
Ectopic Origin of the Left Anterior Descending Artery from the Proximal Right Coronary Artery: An Imaging Report
Authors: Tripolino Cesare , Tassone Eliezer Joseph , Morabito Gaetano , Grillo Placido , Montesanti Gabriella , Missiroli Bindo 
Published: June 2019

Anomalies of the coronary arteries represent rare congenital disorders, which are characterized by a wide spectrum of clinical manifestations. Usually, they are asymptomatic, but sometimes they cause myocardial ischemia or sudden cardiac death. Here, we describe the case of a patient who suffered from angina. Coronary angiography revealed an ectopic origin of the left anterior descending coronary artery from the proximal trait of the right coronary artery and the left circumflex artery, originating from the left sinus; the whole coronary tree was free of atherosclerosis. To better define the coronary anatomy, we performed computed tomography angiography with a three-dimensional reconstruction. The patient was discharged from the clinic after 48 h under optimal medical treatment.
The Predictive Value of Ischemia-Modified Albumin in Renal Ischemia-Reperfusion Injury
Authors: Aytac Ates Huseyin , Yücetaş Uğur , Erkan Erkan , Yucetas Esma , Ulusoy Soner , Kadihasanoglu Mustafa , Behzatoglu Kemal , Culha Mehmet Gokhan , Toktas Mahmut Gokhan 
Published: June 2019

<b><i>Objectives:</i></b> The aim of the study is to investigate the predictive value of ischemia-modified albumin (IMA) as an oxidative stress indicator in renal ischemia-reperfusion (I/R) injury. <b><i>Methods:</i></b> Forty female Wistar Albino rats were divided into 5 groups: Group-1, sham; group-2, 20 min I/R, group-3, 30 min I/R; group-4, 40 min I/R; and group-5, 60 min I/R. Blood samples were taken, and nephrectomy was performed in the sham group before ischemia was induced. At the end of the defined periods for each group, reperfusion was achieved and a blood sample was taken and nephrectomy was performed. At the end of the 6-hour reperfusion period, the blood sample was taken again and the other kidney is removed. IMA in serum and total anti-oxidant status (TAS), total oxidant status (TOS), and oxidative stress index in both serum and tissue were examined. <b><i>Results:</i></b> Serum IMA values were significantly different between the groups (<i>p</i> = 0.009), and there was a significantly difference in TOS values between ischemic serum (<i>p</i> = 0.024) and tissue samples (<i>p</i> = 0.02). However, there was no significant difference in serum and tissue TAS values after ischemia (<i>p</i> = 0.9). Serum IMA, TOS and TAS and tissue TOS and TAS values after reperfusion were not significantly different. There was a significant correlation between tubular damage and ischemia duration in histopathological examination of renal tissue after I/R (<i>p</i> &#x3c; 0.0001). <b><i>Conclusion:</i></b> Serum IMA values increased in parallel with the duration of ischemia, and this increase was supported by histopathological damage findings.
Objective Monitoring of Driving Behavior in Parkinson’s Disease: The Utility of the Chula Parkinson Car®
Authors: Phokaewvarangkul Onanong , Krootjohn Soradech , Yanthitirat Panamet , Anan Chanawat , Bhidayasiri Roongroj 
Published: June 2019

<b><i>Introduction:</i></b> Driving competency is important to evaluate among individuals with Parkinson’s disease (PD). Driving in natural situations is the preferred assessment method; thus, we used a naturalistic driving environment to identify driving competency among individuals with PD in comparison to healthy age-matched controls. <b><i>Methods:</i></b> Based on a power analysis, we recruited 20 participants (10 with PD and 10 healthy age-matched controls). Each participant completed 3 tasks while driving the ChulaPD car, a 4-door sedan installed with computerized monitoring systems. The tasks were forward and backward vehicle movement, reversing into a parking space, and parking parallel to a sidewalk. Trip start and end times, vehicle speed, and acceleration and deceleration times were logged using steering wheel motion, location parking sensors, and dashboard cameras and compared between groups. <b><i>Results:</i></b> Age, gender, possession of a driver’s license, present driving conditions, Thai Mini-Mental State Examination score, and driving experience did not significantly differ between groups. However, the PD group took longer to complete the driving tests (<i>p</i> = 0.002), had slower vehicle speeds (<i>p</i> = 0.002), longer brake times (<i>p</i> = 0.007), and decreased brake pressure ability (<i>p</i> = 0.009). Under normalized conditions, the ratio of failed driver’s license tests was also higher among the PD group than in the control group (70 vs. 10%, <i>p</i> = 0.006). <b><i>Conclusions:</i></b> Individuals with PD had less-than-adequate driving ability based on our naturalistic setting. Our assessment method may be useful in other populations with chronic illnesses or for older adults. We discuss how naturalistic assessments could become the standard for evaluating driving ability in Thailand and elsewhere.
Performance comparison of automatic peak detection for signal analyser
Authors: Jun Teh Yi , Jambek Asral Bahari , Hashim Uda 
Published: June 2019

The aim of this paper is to propose a new peak detection method for a portable device, which know as modified automatic threshold peak detection (M-ATPD). M-ATPD evolves out of ATPD with a focus on reducing computational time. The proposed method replaces the clustering threshold calculation in ATPD with a standard deviation threshold calculation. M-ATPD reduces computational time by 2 times faster compared to ATPD for control signal and 8.65 times faster compared to ATPD for raw biosignals. Modified ATPD also shows a slight improvement in terms of detection error, with a decrease of about 6.66% to 13.33% in peak detection of noise signals. Modified ATPD successfully fixes the error of peak detection on pulse control signals associated with ATPD. For raw biosignals, in total M-ATPD achieved 19.41% lower detection error compare to ATPD.
Design and comparison of printed antennas using meander line technique
Authors: Hamizah Muhamad Mokhtar Nur , Malek Norun Abdul , Jusoh Ahmad Zamani , Ali Khamis , Nadia Mohd Isa Farah , Diyana Abdul Rahman Farah 
Published: June 2019

The interest for compact antennas in wireless communication increase due to the portability and mobility of the communication devices. Generally, an antenna at low frequency exhibits in large physical size. This project investigates the design of an antenna at 400 MHz. The simulation of the antenna has been performed using CST MWS. Since medical applications are dealing with low frequency, it will lead to large size of antenna which brings a challenge for wireless personal area network (WPAN). It is well known that the antenna performance decreases (according to Chu’s equation) as the size of antenna decreases. Therefore, antenna miniaturization using Meander Line (ML) will be taking place to overcome the challenges. Thus, this paper presents a comparison between i) printed dipole antenna without meander line technique, ii) printed dipole with meander line technique and iii) printed monopole antenna with meander line technique. The results show that an estimation of reduction size by 50% can be achieved using Meander Line technique.
Taxa de intemperismo químico e consumo de CO2 em relevo cuestiforme com substrato basáltico e arenítico no estado de São Paulo, Brasil
Authors: Sardinha Diego De Souza , Godoy Letícia Hirata , Da Conceição Fabiano Tomazini 
Published: June 2019

Este trabalho quantificou a taxa de intemperismo químico e consumo de CO2 em relevo cuestiforme com substrato basáltico e arenítico a partir dos elementos sódio, potássio, cálcio, magnésio e sílica, utilizando como área de estudo a bacia do Rio Jaú, no estado de São Paulo, Brasil. A mobilidade dos elementos SiO2, Na+, K+, Ca2+ e Mg2+ no sistema rocha/solo ocorre nos estágios de alteração dos minerais primários, feldspato potássico, albita, anortita, augita e anortoclásio. Nas águas pluviais, os resultados indicam uma deposição anual de 1,28 t/km2/ano de SiO2, 0,60 t/km2/ano de Ca2+, 0,43 t/km2/ano de Mg2+, 0,34 t/km2/ano para K+ e 0,27 t/km2/ano de Na+. Nas águas fluviais, o fluxo específico anual calculado foi de 7,11 t/km2/ano para SiO2, 4,72 t/km2/ano para Ca2+, 2,33 t/km2/ano para Na+, 2,44 t/km2/ano para Mg2+ e 0,88 t/km2/ano para K+. O consumo de CO2 no sistema solo/atmosfera foi de 0,57x106 mol/km2/ano para a bacia do Rio Jaú, e, quando extrapolado para a província geomorfológica das Cuestas Basálticas no estado de São Paulo, foi estimado em 0,03x1012 mol/ano. Essa é uma consideração importante do ponto de vista do aquecimento global. A taxa de intemperismo químico (10 m/Ma) foi comparada com aquela de outros estudos em diferentes províncias geomorfológicas do estado de São Paulo, o qual possui uma variação entre 6 e 22 m/Ma.
Clinical Implications of Identifying Pathogenic Variants in Individuals With Thoracic Aortic Dissection
Authors: Wolford Brooke N. , Hornsby Whitney E. , Guo Dongchuan , Zhou Wei , Lin Maoxuan , Farhat Linda , McNamara Jennifer , Driscoll Anisa , Wu Xiaoting , Schmidt Ellen M. , Norton Elizabeth L. , Mathis Michael R. , Ganesh Santhi K. , Douville Nicholas J. , Brummett Chad M. , Kitzman Jacob , Chen Y. Eugene , Kim Karen , Deeb G. Michael , Patel Himanshu , Eagle Kim A. , Milewicz Dianna M. , J. Willer Cristen , Yang Bo 
Published: June 2019

Background:
Thoracic aortic dissection is an emergent life-threatening condition. Routine screening for genetic variants causing thoracic aortic dissection is not currently performed for patients or family members.

Methods:
We performed whole exome sequencing of 240 patients with thoracic aortic dissection (n=235) or rupture (n=5) and 258 controls matched for age, sex, and ancestry. Blinded to case-control status, we annotated variants in 11 genes for pathogenicity.

Results:
Twenty-four pathogenic variants in 6 genes (COL3A1, FBN1, LOX, PRKG1, SMAD3, and TGFBR2) were identified in 26 individuals, representing 10.8% of aortic cases and 0% of controls. Among dissection cases, we compared those with pathogenic variants to those without and found that pathogenic variant carriers had significantly earlier onset of dissection (41 versus 57 years), higher rates of root aneurysm (54% versus 30%), less hypertension (15% versus 57%), lower rates of smoking (19% versus 45%), and greater incidence of aortic disease in family members. Multivariable logistic regression showed that pathogenic variant carrier status was significantly associated with age <50 (odds ratio [OR], 5.5; 95% CI, 1.6–19.7), no history of hypertension (OR, 5.6; 95% CI, 1.4–22.3), and family history of aortic disease (mother: OR, 5.7; 95% CI, 1.4–22.3, siblings: OR, 5.1; 95% CI, 1.1–23.9, children: OR, 6.0; 95% CI, 1.4–26.7).

Conclusions:
Clinical genetic testing of known hereditary thoracic aortic dissection genes should be considered in patients with a thoracic aortic dissection, followed by cascade screening of family members, especially in patients with age-of-onset <50 years, family history of thoracic aortic disease, and no history of hypertension.
Validation of Genome-Wide Polygenic Risk Scores for Coronary Artery Disease in French Canadians
Authors: Wünnemann Florian , Sin Lo Ken , Langford-Avelar Alexandra , Busseuil David , Dubé Marie-Pierre , Tardif Jean-Claude , Lettre Guillaume 
Published: June 2019

Background:
Coronary artery disease (CAD) represents one of the leading causes of morbidity and mortality worldwide. Given the healthcare risks and societal impacts associated with CAD, their clinical management would benefit from improved prevention and prediction tools. Polygenic risk scores (PRS) based on an individual’s genome sequence are emerging as potentially powerful biomarkers to predict the risk to develop CAD. Two recently derived genome-wide PRS have shown high specificity and sensitivity to identify CAD cases in European-ancestry participants from the UK Biobank. However, validation of the PRS predictive power and transferability in other populations is now required to support their clinical utility.

Methods:

We calculated both PRS (GPS
CAD
and metaGRS
CAD
) in French-Canadian individuals from 3 cohorts totaling 3639 prevalent CAD cases and 7382 controls and tested their power to predict prevalent, incident, and recurrent CAD. We also estimated the impact of the founder French-Canadian familial hypercholesterolemia deletion (
LDLR
delta >15 kb deletion) on CAD risk in one of these cohorts and used this estimate to calibrate the impact of the PRS.

Results:

Our results confirm the ability of both PRS to predict prevalent CAD comparable to the original reports (area under the curve=0.72–0.89). Furthermore, the PRS identified about 6% to 7% of individuals at CAD risk similar to carriers of the
LDLR
delta >15 kb mutation, consistent with previous estimates. However, the PRS did not perform as well in predicting an incident or recurrent CAD (area under the curve=0.56–0.60), maybe because of confounding because 76% of the participants were on statin treatment. This result suggests that additional work is warranted to better understand how ascertainment biases and study design impact PRS for CAD.

Conclusions:
Collectively, our results confirm that novel, genome-wide PRS is able to predict CAD in French Canadians; with further improvements, this is likely to pave the way towards more targeted strategies to predict and prevent CAD-related adverse events.
The Common Rhythm of Action and Perception
Authors: Benedetto Alessandro , Morrone Maria Concetta , Tomassini Alice 
Published: June 2019

Abstract
Research in the last decade has undermined the idea of perception as a continuous process, providing strong empirical support for its rhythmic modulation. More recently, it has been revealed that the ongoing motor processes influence the rhythmic sampling of sensory information. In this review, we will focus on a growing body of evidence suggesting that oscillation-based mechanisms may structure the dynamic interplay between the motor and sensory system and provide a unified temporal frame for their effective coordination. We will describe neurophysiological data, primarily collected in animals, showing phase-locking of neuronal oscillations to the onset of (eye) movements. These data are complemented by novel evidence in humans, which demonstrate the behavioral relevance of these oscillatory modulations and their domain-general nature. Finally, we will discuss the possible implications of these modulations for action–perception coupling mechanisms.
“My Kingdom Lasts Forever”
Authors: Lanier Gregory R. 
Published: June 2019

AbstractIn the field of research on the Jewish background of NT Christology, exalted patriarchs (famous OT figures endowed with transcendent characteristics) play a prominent role. One key figure has been almost overlooked in such comparative work: Job as portrayed in the Testament of Job. As a king with a glorious heavenly throne, a position at the right hand of God, and an eternal kingdom, this Job bears a profile on par with—if not exceeding—that of other important figures in post-biblical Jewish literature (Adam, Abel, Enoch, Melchizedek, Joseph, and Moses). This study argues that Job should be added to the roster of such Jewish figures for future work on early Christology.
Jesus’s Special Knowledge in the Gospel of John
Authors: Tripp Jeffrey 
Published: June 2019

AbstractThe Fourth Gospel portrays Jesus as having special knowledge of himself and his future, but also of the people and events around him. While John’s Jesus always has divine insight, he does not always share it. Jesus neither shares nor hides special knowledge haphazardly, but in service of two interrelated goals: sharing special knowledge persuades doubting characters in order to build a group of believers to receive the Spirit after his death. Jesus hides special knowledge in order to ensure a proper death at his hour. In this way, John explains how a character who exerts sovereign control throughout the Gospel is nevertheless betrayed and executed.
Dynamis eis Soterian
Authors: Hauck Marion Christina 
Published: June 2019

AbstractThis study shows that the syntagma δύναµις εἰς σωτηρίαν was widely used in ancient Greek literature of the Classical, Hellenistic, and Greco-Roman periods. A semantic context analysis reveals that “danger” is the common intersection of all contexts in which the syntagma δύναµις εἰς σωτηρίαν occurs. In a modified way it also appears in texts of the New Testament (Rom 1:16; 1 Pet 1:5): By using δύναµις (θεοῦ) εἰς σωτηρίαν in a context focused on danger, Paul (as well as the author of 1 Peter) indicates that his use of the syntagma is consistent with the pagan, non-biblical use of δύναµις εἰς σωτηρίαν.
Putting on the New Self
Authors: Starling David 
Published: June 2019

AbstractThis article argues that the principal background against which the clothing metaphor in Eph 4:22, 24 would have been understood by the letter’s original hearers is that of the theater, within which changes of costume signalled changes of identity, character, or fate. After a brief survey of recent scholarly commentaries (which pay surprisingly little attention to the possibility of a theatrical background to the metaphor in these verses) it highlights instances of similar expressions within Greco-Roman theatrical contexts, both literal and metaphorical, discusses the relevant aspects of ancient dramatic theory and practice, and explores the implications of this reading for theological interpretation of Ephesians.
Merodoras nheco, new genus and species from Rio Paraguay basin, Brazil (Siluriformes, Doradidae), and nomination of the new subfamily Astrodoradinae
Authors: HIGUCHI HORÁCIO , BIRINDELLI JOSÉ L.O. , SOUSA LEANDRO M. , BRITSKI HERALDO A. 
Published: June 2019

Merodoras nheco, new genus and species of Doradidae (Siluriformes) is described from Rio Paraguay basin, Brazil. The new genus belongs to the new subfamily Astrodoradinae, a monophyletic group formally named herein that includes, besides Merodoras, Amblydoras, Anadoras, Astrodoras, Hypodoras, Physopyxis, and Scorpiodoras. This group is diagnosed by the possession of: lacrimal serrated and participating in the orbital margin, four to seven pleural ribs; spines on the postcleithral process; postero-inferior portion of the coracoid exposed. Merodoras nheco, new species, is distinguished from other doradids by the unique combination of the following characteristics: 1) tips of retrorse spines on the midlateral scutes ventrally oriented in adults; 2) incomplete lateral line, with only a few midlateral scutes anteriorly; 3) pectoral girdle entirely exposed ventrally, with the opening of the arrector ventralis inferior reduced to a small fossae on the anterior edge of the coracoid; 4) caudal fin truncate; 5) dorsal-fin spine smooth, without serrae on both faces; 5) lacrimal serrated; 6) lateral ethmoid serrated. Merodoras nheco inhabits the “Pantanal Matogrossense,” a flooded portion of the upper Rio Paraguay basin in western Brazil.
A new species of coralsnake (Micrurus: Elapidae) from southern Brazil
Authors: DI-BERNARDO MARCOS , BORGES-MARTINS MARCIO , DA SILVA (Jr.) NELSON JORGE 
Published: June 2019

A new species of triadal coralsnake (Micrurus) is described from Rio Grande do Sul, Brazil. The new species differs from other Micrurus species in southern Brazil by the following characters: snout mostly black, head completely black, white gular region, triads with middle black ring 1.5 to 2 times longer than the external black rings, white rings shorter than the external black rings. The new species occurs sympatrically with M. altirostris and adds to the following known triadal species for the region: M. baliocoryphus, M. pyrrhocryptus, M. lemniscatus, and Micrurus decoratus. Its current range is restricted to Rio Grande do Sul but it may reach adjacent areas of Argentina and Paraguay.
A new species of freshwater crab of the genus Microthelphusa (Brachyura: Pseudothelphusidae) from a remote isolated cloud forest on a tabletop mountain in western Guyana, South America
Authors: CUMBERLIDGE NEIL 
Published: June 2019

A new species of freshwater crab of the genus Microthelphusa Pretzmann, 1968, from Guyana, South America is described. Microthelphusa meansi, new species, was collected from a remote isolated cloud forest in the Wokomung Massif, a tabletop mountain (tepui) in western Guyana at over 1,000 m above sea level. The conspicuous horseshoe-like marginal lobe and the dome-like auxiliar cephalic lobe of the first gonopod clearly distinguish this species from all 12 congeners.