bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efectos de las buenas prácticas en el valor de marca de las universidades chilenas
Authors: León Mauricio , Améstica-Rivas Luis , King-Domínguez Andrea , Gurrola Cesar 
Published: September 2019

Rev.esc.adm.neg
El presente artículo tiene como objetivo valorar financieramente las marcas de las 58 universidades chilenas, creando un ranking de desempeño e identificando las principales variables que inciden en su valor. Para estos efectos, se utiliza una adaptación del método de múltiplos de valoración de empresas en base a los estados financieros de las instituciones para el período 2012 - 2015, un análisis factorial de componentes principales y una regresión lineal múltiple a partir de variables institucionales.
Como resultados principales se establece que un 88 % de las universidades pose un valor de marca positivo, destacando las dos universidades líderes del país. Estos resultados son coincidentes con rankings de calidad y reputación, existiendo una correlación positiva entre el valor de marca y los rankings. Los determinantes del valor de la marca son la calificación del cuerpo académico, dada por su nivel de postgraduación, y la infraestructura institucional.
Aunque el valor de marca en la educación superior ha recibido atención académica en los últimos años, encontrar un mejor método para determinar su valor y las dimensiones que lo explican no está exento de cuestionamientos. Sin embargo, avanzar empíricamente es un reflejo de la inquietud científica de una dimensión poco estudiada como es la perspectiva económica – financiera. Se pretende, por tanto, que los resultados puedan servir de apoyo a los gestores universitarios, al poder descifrar las variables que contribuyen favorablemente en el valor de su marca y, por ende, generar estrategias adecuadas para fortalecerla o mantenerla en el tiempo.
Integrated Reservoir Characterization and Simulation to Optimize Recovery from a Mature Carboniferous North Sea Gas Field with Water Influx
Authors: Weijermans Peter-Jan , Huibregtse Paul , Arts Rob , Benedictus Tjirk , De Jong Mat , Hazebelt Wouter , Vernain-Perriot Veronique , Van der Most Michiel 
Published: September 2019

Abstract
The E17a-A gas field, located offshore The Netherlands in the Southern North Sea, started production in 2009 from Upper Carboniferous sandstones, initially from three wells. Since early production history of the field, the p/z plot extrapolation has consistently shown an apparent Gas Initially In Place (GIIP) which was more than 50% higher than the volumetric GIIP mapped. The origin of the pressure support (e.g. aquifer support, much higher GIIP than mapped) and overall behavior of the field were poorly understood.
An integrated modeling study was carried out to better understand the dynamics of this complex field, evaluate infill potential and optimize recovery. An initial history matching attempt with a simulation model based on a legacy static model highlighted the limitations of existing interpretations in terms of in-place volumes and connectivity. The structural interpretation of the field was revisited and a novel facies modeling methodology was developed. 3D training images, constructed from reservoir analogue and outcrop data integrated with deterministic reservoir body mapping, allowed successful application of Multi Point Statistics techniques to generate plausible reservoir body geometry, dimensions and connectivity.
Following a series of static-dynamic iterations, a satisfying history match was achieved which matches observed reservoir pressure data, flowing wellhead pressure data, water influx trends in the wells and RFT pressure profiles of two more recent production wells. The new facies modeling methodology, using outcrop analogue data as deterministic input, and a revised seismic interpretation were key improvements to the static model. Apart from resolving the magnitude of GIIP and aquifer pressure support, the reservoir characterization and simulation study provided valuable insights into the overall dynamics of the field – e.g. crossflows between compartments, water encroachment patterns and vertical communication. Based on the model a promising infill target was identified at an up-dip location in the west of the field which looked favorable in terms of increasing production and optimizing recovery. At the time of writing, the new well has just been drilled. Preliminary logging results of the well will be briefly discussed and compared to pre-drill predictions based on the results of the integrated reservoir characterization and simulation study.
The new facies modeling methodology presented is in principle applicable to a number of Carboniferous gas fields in the Southern North Sea. Application of this method can lead to improved understanding and optimized recovery. In addition, this case study demonstrates how truly integrated reservoir characterization and simulation can lead to a revision of an existing view of a field, improve understanding and unlock hidden potential.
Polymorphism of MUC1 gene in Vietnamese gastric cancer patients: a case-control study
Authors: Nguyen Lan Thi Ngoc , Dang Dzung Thi Ngoc , Ta Van Thanh , Dang Huy Quang , Tran Chuc Van , Yamaguchi Masamitsu 
Published: September 2019

Abstract
Background Gastric cancer is a malignant type of cancer associated with many factors such as environment, behavior, infection, and genetics, which include Single Nucleotide Polymorphism. A few studies revealed polymorphisms of the Mucin 1 gene have a role and significance as a susceptible factor contributing to gastric cancer. The aim of this research is to evaluate the association between Single Nucleotide Polymorphisms of the Mucin 1 gene and Vietnamese gastric cancer patients.Methods 302 gastric cancer patients and 304 controls were interviewed for social-economic characteristics, smoking and drinking status, personal and family history of gastric diseases. Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism analysis. The association of Single Nucleotide Polymorphisms with gastric cancer was evaluated using multifactor regression models.Results AA genotype for rs4072037 was found to be highly associated with gastric cancer (OR: 2.07 (95% CI: 1.46-2.90). GG genotype for rs2070803 increased the risk of gastric cancer (OR:1.96 (95% CI: 1.37-2.78). These genotypes in combination with other factors such as old age, male gender, alcoholism and personal history of gastric disease also showed an increased risk of having gastric cancer.Conclusions rs4072037 and rs2070803 of Mucin 1 genes are two genotypic risk factors of gastric cancer. Those in combination with other factors such as gender, family history, smoking and drinking habits significantly increase the risk of gastric cancer.
Relationship of lymphovascular invasion with lymph node metastasis and prognosis in superficial esophageal carcinoma: Systematic review and meta-analysis
Authors: Yang Jinxin , Lu Zhouyi , Wang An , Tan Yulong , Zhang Dekang 
Published: September 2019

Abstract
Background:The development of tumor cells inside the lymphatics or blood vessels is known as lymphovascular invasion (LVI). The correlation between LVI, lymph node metastasis (LNM), and the diagnosis of superficial esophageal carcinoma (SEC) remains unclear.Methods:We searched Embase, PubMed, Web of Science, and Cochrane Library databases for prospective articles to better understand the relationship between LVI, LNM, and SEC diagnosis.Results:We included 28 articles containing data for 5041 patients (range: 29-498) in our meta-analysis. The hazard ratio between LVI and overall survival (OS) was 1.62 with 95% confidence interval (CI) (1.17-2.26; p = 0.004) and the odds ratio between LVI and LNM was 5.7 with 95% CI (4.43-7.33; p < 0.0001). LVI in patients diagnosed with SEC results in a poor OS rate and a higher rate of LNM.Conclusions:The results indicate that LVI plays a dominant role in the prognosis of LNM in SEC and in the prognostic prediction for SEC.Keywords: Lymphovascular invasion; lymph node metastasis; prognosis; superficial esophageal carcinoma
Determinants of Undernutrition among Children Under-Five Years Old in Southern Ethiopia: Does Pregnancy Intention Matter? A Community-Based Unmatched Case-Control Study
Authors: Shaka Mohammed Feyisso , Woldie Yetayal Birhanu , Lola Hirbaye Mokona , Olkamo Kalkidan Yohannes , Anbasse Adane Tesfaye 
Published: September 2019

Abstract
Background Stunting, which describes a small height for one’s age, is an indicator of chronic malnutrition. It develops mainly as a result of prolonged food deprivation or a chronic disease or illness. Unintended pregnancies and unplanned births are among the psychological factors that negatively affect the nutritional status of children. Therefore, this study aimed to determine the effects of unintended pregnancies and other family and child characteristics on the nutritional status of children under 5 years old. Methods A community-based unmatched case-control study was conducted among 302 children (151 cases and 151 controls) 6–59 months old in Wonago town, Gedeo Zone, SNNPR, Ethiopia. The cases were randomly selected from among the stunted children, and the controls were randomly selected from among the non-stunted children. The descriptive characteristics of the respondents were compared using the chi-squared test, and a multivariable logistic regression was used to assess the effects of an unintended pregnancy on stunting, after controlling for the other variables, with a p value of 0.05. Results The result revealed that unintended pregnancy is found to be among predictors of stunting where children from unintended pregnancy were about three times more likely to be stunted [AOR: 2.62, CI: (1.26, 5.45)]. The other predictors identified in this study were educational status of the father, wealth index of the household and daily meal frequency. From the finding, children from illiterate fathers [AOR: 3.43, CI: (1.04, 11.29)], children from poorer household economic status [AOR: 2.32, CI: (1.20, 4.49)] and children whom their daily meal frequency is below the recommended number of feeding [AOR: 4.50, CI: (1.31, 15.49)] were found to be more stunted. Conclusions Based on the results of this study, the children born from unintended pregnancies exhibited a significantly higher risk of stunting. Therefore, preventing unintended pregnancy could play a great role in decreasing the risk of stunting in children.
Periodontal disease status and treatment need among a Kurdish population in Sulaimani/ Iraq as assessed by CPITN index.
Authors: Gul Sarhang 
Published: September 2019

Abstract
Background This study identifies the prevalence and severity of periodontal diseases in a given population of Sulaimani using the Community Periodontal Index of Treatment Needs (CPITN) and attempts to find the relation of CPITN with age, sex, location, visit to dentist, tooth brushing, use of mouth wash and interdental aids, systemic disease, smoking status and missing teeth.Methods Subjects attending Periodontics clinics at College of Dentistry, University of Sulaimani were examined. Periodontal examinations were performed using CPITN, plaque index (PI) and bleeding index (BI). Other data including location, visit to dentist, tooth brushing, use of mouth wash and interdental aids, presence of systemic diseases, smoking status and missing teeth were also collected. The data were subjected to logistic regression to find a relation between periodontal status (CPITN ≥ 3 or not as dependent variable) and other variables.Results Among the 1354 subjects (mean age 30.8 ± 12.9 years) examined, 43.6% were male and the majority of these (80.9%) were from urban areas. The mean PI and BI were 0.64±24 and 0.39±0.28, respectively. Calculus was the most prevalent highest score amongst examined subjects (62.2%), followed by shallow pocket (22.2%) and bleeding (9%). Among the sextants, lower central sextants were found to have the highest percentage of calculus (73.1%), followed by lower left (49.7%) and lower right (48.7%). The highest percentages of shallow and deep pockets were found at upper left (14%, 2.5%, respectively) and upper right (11.4%, 3.2%, respectively) sextants. Logistic regression analysis showed that age, sex, frequency of brushing and smoking significantly correlated with CPITN scores.Conclusion Prevalence and severity of periodontal diseases are high in the examined population and at population level age, sex, brushing and smoking were shown to have an impact on periodontal condition.
The different dietary sugars modulate the composition of the gut microbiota in honeybee during overwintering
Authors: Wang Hongfang , Liu Chunlei , Liu Zhenguo , Wang Ying , Ma Lanting , Xu Baohua 
Published: September 2019

Abstract
Background: The health of honeybee colonies is critical for bee products and agricultural production, and colony health is closely associated with the bacteria in the guts of honeybees. Although colony loss in winter is now the primary restriction in beekeeping, the effects of different sugars as winter food on the health of honeybee colonies are not well understood. Therefore, in this study, the influence of different sugar diets on honeybee gut bacteria during overwintering was examined.
Methods: The bacterial communities in honeybee midguts and hindguts before winter and after bees were fed honey, sucrose, and high-fructose syrup as winter-food were determined by targeting the V4 region of 16S rDNA using the Illumina MiSeq platform.
Results: The dominant microflora in honeybee guts were the phyla Proteobacteria (63.17%), Firmicutes (17.61%; Lactobacillus, 15.91%), Actinobacteria (4.06%; Bifidobacterium, 3.34%), and Bacteroidetes (1.72%). The dominant taxa were conserved and not affected by season, type of overwintering sugar, or spatial position in the gut. However, the relative abundance of the dominant taxa was affected by those factors. In the midgut, microbial diversity of the sucrose group was higher than that of the honey and high-fructose syrup groups, but in the hindgut, microbial diversity of the honey and high-fructose groups was higher than that in the sucrose group. Sucrose increased the relative abundance of Actinobacteria (Bifidobacteriales Bifidobacteriaceae) and Alphaproteobacteria (Rhizobiales and Mitochondria) of honeybee midgut, and honey enriched the Bacteroidetes and Gammaproteobacteria (Pasteurellales) in honeybee hindgut. Hgh-fructose syrup increased the relative abundance of Betaproteobacteria (Neisseriales: Neisseriaceae) of the midgut.
Conclusion: The type of sugar used as winter food affected the relative abundance of the dominant bacterial communities in honeybee guts, not the taxa. which could affect the health and safety of honeybee colonies during overwintering. The presence of the supernal Alphaproteobacteria, Bifidobacteriales, and Lactobacillaceae in the gut of honeybees fed sucrose and cheaper than honey both indicate that sucrose is very suitable as the overwintering food for honeybees.
Physical integrity of three Long-Lasting Insecticidal Net products 30 months after a mass-distribution campaign in Benin
Authors: AHOGNI Idelphonse Bonaventure , Gnanguenon Virgile , Sovi Arthur , Salako Albert Sourou , Azondekon Roseric , Dagnon Jean-Fortuné , Attolou Roseline H. , Gnanvi Janyce J. , Akinro Bruno , Yovogan Boulais , Sominahouin André Aimé , Nwangwu Udoka C , Tokponnon Filémon , Padonou Gil Germain , Akogbeto Martin Codjo 
Published: September 2019

Abstract
Abstract
Background
The effectiveness of long-lasting insecticidal nets (LLINs) mainly relies on their physical integrity, an important indicator of the LLINs durability in households. The present study aims to assess this physical integrity for three widely used LLIN products: DawaPlus®2.0, PermaNet®2.0 (polyester) and DuraNet® (polyethylene), distributed in Benin during the mass campaign of 2014.
Methods
The study was conducted from October 2014 to June 2017 in three districts of Benin: Tori-Bossito, Toffo, and Ouesse. Nine hundred LLINs (a cohort of 300 LLINs per product) in use and found hanging on sleeping materials were selected and tagged. Every six months, the LLIN attrition and their physical condition was monitored. The holes were counted by category allowed to calculate the proportionate hole index (pHI) and classify the LLINs into "good ", "serviceable" or "torn" categories. Factors associated with loss of integrity have also been identified following World Health Organization Guidelines.
Results
After 30 months of use, 55.9% (n= 503; 95% CI: 52.6-59.2) of the LLINs were lost. Attritions due to physical damage were similar between the LLIN products and were respectively 28.3% for PermaNet® 2.0, 29.7% for DawaPlus® 2.0, and 31% for DuraNet® (p˃0.05). The mean pHI was significantly higher for DuraNet® LLINs (pHI= 1431) than DawaPlus® 2.0 (pHI =366) and PermaNet® 2.0 (pHI =321) (<0.001). A significant difference was also observed between the proportion of LLINs in “torn” condition and included 8.7% of PermaNet® 2.0, 14.3% of DawaPlus® 2.0, and 34.1% of DuraNet® (p <0.001). The use of LLINs every night, the frequency of washing and other factors were significantly associated with the physical damage of the LLINs (p <0.001).
Conclusion
These results suggest that the physical barrier conferred by the LLIN can be significantly affected during the normal course of its use depending on the type of product distributed. National malaria programs must, therefore, consider the physical integrity performance in local conditions in the choice of LLIN product to be distributed.
Keywords: LLINs, physical integrity, pHI, malaria, Benin.
Molecular analysis of prothrombotic gene variants in venous thrombotic diseases. Different risk factors in different sex and clinical forms.
Authors: Cernera Gustavo , Amato Felice , Elce Ausilia , Liguori Renato , Bruzzese Dario , Lullo Antonella Miriam Di , Castaldo Giuseppe , Zarrilli Federica , Comegna Marika 
Published: September 2019

Abstract
Background The role of prothrombotic gene variants as risk factors for venous thrombotic diseases is controversial and the ordering of tests for thrombophilia in the clinical context is scarcerly respective of evidence-based data. Methods We studied FVL, FVR2, FII G20210A, MTHFR C677T and A1298C, beta-fibrinogen -455 G>A, FXIII V34L, HPA-1 L33P variants and PAI-1 4G/5G alleles in: 343 patients with deep vein thrombosis (DVT), 164 with pulmonary embolism (PE), 126 with superficial vein thrombosis (SVT), 118 with portal vein thrombosis (PVT), 75 with cerebral vein thrombosis (CVT), 119 with retinal vein thrombosis (RVT) in comparison with 430 subjects from the general population (GP) of the same geographical area (Southern Italy). Results About 40% of patients with DVT, PE and SVT have a prothrombotic predisposition represented by FVL, FVR2 and FII G20210A variants (significantly more frequent than in the general population), significantly higher in PE males. While, in patients with PVT and CVT only FII G20210A variant is more frequent particularly in females. Finally, RVT is poorly related to prothrombotic risk factors, confirming that local vascular and other factors have a pivotal role in its pathogenesis. Conclusions Our data indicate that only FVL, FVR2 and FII G20210A are related to vein thrombotic diseases while all the other gene variants, frequently ordered in the clinical context, do not have a role as risk factors. Furthermore, the evidence of a sex difference for some variants, once confirmed in larger populations, may help to promote sex-specific prevention of such diseases.
A comprehensive bioinformatics analysis Young-Aged Coronary Heart Disease
Authors: Liao Xinxue , Zhong Xiang-bin , Zhou Hua-qiang , Zhang Shao-Zhao , Zhou Hui-min , Sun Xiu-ting , Huang Man , Yang Da-ya , Guo Yue , Xiong Zhen-yu , Zhuang Xiao-dong , Liao Xin-xue 
Published: September 2019

Abstract
Background Coronary heart disease (CHD) is a leading cause of morbidity and mortality worldwide[1]. Although effective primary and secondary prevention successfully reduced the mortality of CHD, morbidity and mortality of young aged coronary heart disease (YA-CHD) didn’t decrease. However, little is known about the prevalence and mechanism of YA-CHD.Methods Dataset GSE 12288 from Gene Expression Omnibus was imported and performed comprehensive bioinformatics analysis, including gene ontology analysis (GO analysis), pathway analysis, protein-protein interaction network (PPI) analysis and core network analysis.Results RAP1A, which regulates platelet integrin activation and has a critical role in platelet production, was significantly up regulated, while TNKS2, which keeps the integrity of the leukocyte telomere structure and shows a significant association with longevity, was significantly downregulated. Biological process analysis showed “phagosome” pathway was mostly significant related to YA-CHD. Innate immune response module and type I interferon signaling module, interacts with IRF1, may major in the regulation of YA-CHD progression and maybe the potential therapeutic target of YA-CHD.Conclusions RAP1A and TNKS2 in peripheral leukocytes may serve as novel biomarkers in predicting the onset of YA-CHD. Further studies about weather IRF1 influence YA-CHD through regulating innate immune type I interferon signaling pathway was needed.
Comparative chloroplast genomics of Fritillaria (Liliaceae), inferences for phylogenetic relationships between Fritillaria and Lilium and genome evolution
Authors: Huang Jiao , Yu Yan , Liu Yan-Mei , Xie Deng-Feng , He Xing-Jin , Zhou Song-Dong 
Published: September 2019

Abstract
Background Fritillaria is a genus consisting of about 140 species that has important medicinal and horticultural values. The monophyly of Fritillaria and phylogenetic relationships with Lilium were previously not fully resolved. The study involved the most comprehensive chloroplast genomes samples to date referring to Old and New World clades of Fritillaria as identified in earlier studies.Results We reported and compared eleven newly sequenced whole-plastome sequences of Fritillaria as well as characterization of SSRs and repeat sequence. These 11 plastomes proved highly similar in overall size (151,652-152,434bp), genome structure, gene content and order; Comparing them with other species of Liliales (6 out of 10 families) indicated the same similarity but showed some structural variations due to the contraction or expansion of the IR regions out or into of adjacent single-copy regions. A/T mononucleotides, palindromic and forward repeats were the most common types. Six hypervariable regions ( rps16 - trnQ, rbcL - accD, accD - psaI, psaJ - rpl33, petD - rpoA and rpl32 - trnL ) were discovered based on 26 Fritillaria whole-plastomes to be potential molecular markers. 26 species of Fritillaria plastomes and 21 species of Lilium plastomes were combined in a phylogenomic study with 3 Cardiocrinum species as out groups. Fritillaria was monophyly with moderate support as sister to Lilium based on 64 protein-coding genes (CDS) and the interspecific relationship within subgenus Fritillaria has strong resolution. The topology recovered from the whole plastome and single-copy gene data sets was the same as for coding gene data, but weak support for monophyly of Fritillaria .Conclusions The phylogenomic analysis reconstructed a topology that had some incongruences with previous studies. The six hypervariable regions can be used as candidate DNA barcodes for global genetic diversity detection of Fritillaria . The phylogenomic framework from this study can guide extensive genomic sampling to further discern the relationships among the Old and New World clades of Fritillaria and Lilium .