bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unlocking the In Situ Reconstruction of Bi/Bi2O2CO3 Electrocatalyst Toward Efficiently Converting CO2 into Formate
Authors: Yang Jiatai , Zhang Xiaoyan , Zhang Shengnan , Liu Kang , Zhao Jingwen , Zhang Lixue , Guo Shaojun 
Published: November 2024

AbstractElectrochemical reducing CO2 into formic acid has been demonstrated to be an economically viable pathway to relieve the greenhouse effect and obtain value‐added chemical feedstocks. Herein, Bi/Bi2O2CO3 is developed via the combination of sulfur‐assisted disassembly and an in situ reconstruction process. Profiting from the enlarged surface area and the generation of the high active heterointerface between metallic Bi and Bi2O2CO3, the as‐obtained Bi/Bi2O2CO3 exhibits high performance toward converting CO2 molecules into formate (HCOO−), attaining the HCOO− Faradaic efficiency (FEHCOO‐) over 97% in the current density range from 200 to 1000 mA cm−2 in both alkaline (1 m KOH) and near neutral (0.5 m KHCO3) electrolytes, along with excellent stability. In situ spectroscopic data unraveled the reconstruction process from Bi2S3/Bi2O2CO3 to Bi/Bi2O2CO3 and corroborated that the conversion of CO2 into formate is through the *OCHO intermediate, deepening the insights into the understanding of the Bi‐based electrocatalyst reconstruction and CO2RR mechanism.
Recent Therapeutic Advancements for Gaucher Disease
Authors: Pradhan Lipi , Manna Sumit , Pragya Pragya , Mukherjee Sudip 
Published: November 2024

AbstractGaucher Disease (GD) is a well‐known lysosomal storage disease resulting from mutations in the GBA1 gene. GD exhibits a range of clinical manifestations, each with unique symptoms and severity levels. This review explores the genetic foundations of GD, highlighting the significance of Glucocerebrosidase (GCase) deficiency, resulting in the skeletal complications associated with GD, such as osteonecrosis, fractures, and bone pain, all of which significantly negatively influence the quality of life for patients. Over 700 mutations in the GBA1 gene are found to cause variations in gene expression in GD, indicating the disease's complexity and the need for continued research. Early diagnosis and prognosis evaluation depend heavily on diagnostic approaches integrating laboratory assessments, genetic testing, and clinical symptoms. Treatment strategies like enzyme replacement therapy (ERT) and substrate reduction therapy (SRT) have advanced, but issues like high costs and invasiveness still exist. This review focuses on novel therapeutic approaches that show promise in treating GD, including gene and cell‐based therapies, pharmacological chaperone therapy (PCT), and drug delivery via nanoparticles. Finally, discussions on current clinical trials, limitations of the advanced therapies, and future scope are summarized.
BRD4 Degradation Enhanced Glioma Sensitivity to Temozolomide by Regulating Notch1 via Glu‐Modified GSH‐Responsive Nanoparticles
Authors: Yi Linbin , Zhang Zhenyu , Zhou Wenjie , Zhang Yunchu , Hu Yuzhu , Guo Anjie , Cheng Yongzhong , Qian Zhiyong , Zhou Peizhi , Gao Xiang 
Published: November 2024

AbstractTemozolomide (TMZ) serves as the principal chemotherapeutic agent for glioma; nonetheless, its therapeutic efficacy is compromised by the rapid emergence of drug resistance, the inadequate targeting of glioma cells, and significant systemic toxicity. ARV‐825 may play a role in modulating drug resistance by degrading the BRD4 protein, thereby exerting anti‐glioma effects. Therefore, to surmount TMZ resistance and achieve efficient and specific drug delivery, a dual‐targeted glutathione (GSH)‐responsive nanoparticle system (T+A@Glu‐NP) is designed and synthesized for the co‐delivery of ARV‐825 and TMZ. As anticipated, T+A@Glu‐NPs significantly enhanced penetration of the blood‐brain barrier (BBB), facilitated drug uptake by glioma cells, and exhibited efficient accumulation in brain tissue. Additionally, T+A@Glu‐NPs exhibited augmented efficacy against glioma both in vitro and in vivo through the induction of apoptosis, inhibition of proliferation, and cell cycle arrest. Furthermore, mechanistic exploration revealed that T+A@Glu‐NPs degraded the BRD4 protein, leading to the downregulation of Notch1 gene transcription and the inhibition of the Notch1 signaling pathway, thereby augmenting the therapeutic efficacy of glioma chemotherapy. Taken together, the findings suggest that T+A@Glu‐NPs represents a novel and promising therapeutic strategy for glioma chemotherapy.
High Power Density Micro Thermoelectric Generators for Powering IoTs
Authors: Dutt Aditya S. , Pulumati Nithin B , Deng Kangfa , Wagner Jens , Brönner Andreas , Ellinger Frank , Schierning Gabi , Nielsch Kornelius , Reith Heiko 
Published: November 2024

AbstractMicro thermoelectric generators (µTEGs) can harvest waste heat to generate electricity, making them a potential solution to the growing problem of powering autonomous electronics, such as sensors for the Internet of Things. Until now, µTEGs have not been able to provide power for these applications. This is because the output power of µTEGs is limited due to insufficient contacts and poor thermal coupling between the device and the heat source. In this work, the contact resistance as well as the thermal coupling between the heat source and the device through process optimization are improved. The former by improved electrochemical deposition (ECD) conditions, the latter by introducing a thin solder adhesion layer, which smooths the uneven surface of µTEG due to its good wetting properties. Using these improvements in combination with optimized packing density, here the fabrication and characterization of a µTEG with 126 leg pairs connected in series are reported that exhibits an open circuit voltage of 339.2 mV at a temperature difference of 20.6 K and a record‐high normalized power density of 25.1 µW cm−2 K−2 for ECD based µTEGs. This µTEG is used to power a temperature sensor, bringing this work one step closer to application.
Hollow Microsphere Structure and Spin‐Polarized Surface Capacitance Endow Ultrafine Fe7S8 Nanocrystals with Excellent Fast‐Charging Capability in Wide‐Temperature‐Range Lithium‐Ion Batteries
Authors: Han Meisheng , Zheng Kunxiong , Liu Jie , Zou Zhiyu , Mu Yongbiao , Hu Hengyuan , Yu Fenghua , Li Wenjia , Wei Lei , Zeng Lin , Zhao Tianshou 
Published: November 2024

AbstractFe7S8 as a conversion‐type anode shows high capacity in lithium‐ion batteries (LIBs). Nevertheless, the sluggish ion transport rate, low electron conduction behavior, and large volume change upon cycling limit its applications in fast‐charging wide‐temperature‐range LIBs. Here, a simple hydrothermal and subsequent solid‐phase high‐pressure sulfidation route is proposed to synthesize a hollow Fe7S8/N‐doped C microsphere structure. The hollow space is enveloped by the spheres’ shell consisting of ultrafine Fe7S8 nanocrystals (≈8 nm) embedded into N‐doped C matrix, which enhances ion transport and electrical conduction, and accommodates the volume expansion of Fe7S8. Remarkably, in situ magnetometry reveals that spin‐polarized surface capacitance occurs during the stage of conversion reaction, in which the formed Fe and Li2S act as electrons and ions acceptor, respectively, to construct space charge zone at their interfaces, thus enhancing lithium transport and storage. Accordingly, the hollow microspheres show high gravimetric energy density and outstanding fast‐charging capability along with excellent cycling stability in Ah‐level pouch cells operating from ‐40 to 60 °C. For the first time, this work confirms the effectiveness of spin‐polarized surface capacitance effect on enhancing ion storage and transport in fast‐charging wide‐temperature‐range LIBs.
The Investigation of Fe─F Bond Chemistry on Structural Stability for Highly Durable Layered Na2FePO4F Cathode
Authors: He Liang , Ge Xiaochen , Wang Xu , Fang Jing , Lai Yanqing , Zhang Zhian 
Published: November 2024

AbstractLayered iron (Fe) ‐based fluorophosphates, Na2FePO4F (NFPF) stands for a cost‐effective and voltage‐advantageous cathode material for sodium‐ion batteries. Nevertheless, the lack of stability imposes constraints on its development and the decay mechanism remains shrouded in ambiguity. Herein, this work proposes the breakup of Fe─F bond in octahedral dimer accountable for the dissolution of redox centers and the formation of electrochemically inert phase, ultimately leading to the deterioration of electrochemical stability. To verify and address this, Boron (B) atoms situated in interstitial positions of PO4 tetrahedra appearing trigonal BO3 can be specifically targeted to enhance bond covalency and tailor electronic rearrangements at Fe─F bonds, thus stabilizing the octahedral dimer structure. This also facilitates rapid Na+ diffusion dynamics and accelerated electronic conductivity. As expected, NFPF‐B exhibits an ultra‐high discharge specific capacity (118.34 mAh g−1 at 0.1C) and excellent long‐term durability (capacity retention of 91.9% after 1000 cycles). The stability of the octahedra dimer is underscored by minimal volume change (2.9%) within the two‐stage biphase reaction of sodium storage mechanism. This work elucidates the enduring degradation mechanism of NFPF from octahedral dimers and offer theoretical guidance for Fe‐based cathode materials with prolonged stability.
Technical note: Effects of chemical, radiational, and thermal treatment of bone tissue on material stiffness and anisotropy
Authors: Polvadore Taylor A. , Calhoun Grace V. , Daegling David J. 
Published: November 2024

AbstractObjectivesWe evaluated the effects of four treatments for pathogen inactivation in bone tissue (ethanol storage, formalin fixation, gamma irradiation, and heat treatment via autoclave) on stiffness and anisotropy values in bone samples.Materials and MethodsCortical bone samples from the humerus of 14 bovine specimens were subjected to Knoop microindentation analysis in longitudinal and transverse planes of section and four indenter orientations within each section. From each specimen, individual samples were assigned to one of five treatment conditions: 50% ethanol‐saline solution, formalin immersion, gamma irradiation, autoclave, and buffered saline (controls). Each sample was microindented 100 times and the resultant stiffness data were analyzed by a resampled factorial analysis of variance.ResultsFirst‐ and second‐order interactions as well as main effects of indenter orientation, treatment, and specimen were significant for both transverse and longitudinal sections, with the sole exception that indenter orientation‐treatment interaction was nonsignificant for longitudinal sections. Interaction plots reveal that thermal (autoclave) and irradiation treatments depress stiffness values the most, while patterns of indentation stiffness at different orientations are relatively unaffected.DiscussionPatterns of anisotropy are relatively unaffected by preservative treatments, but elastic modulus changes are consistent and unambiguous. Formalin and ethanol treatments are most comparable to controls and represent the best preservative media for mechanical testing. These options, however, are likely to be the least effective for ensuring the inactivation or sterilization of potentially contaminated samples.
T‐förmige 14 Elektronen‐Rhodiumkomplexe: Potentiell aktive Spezies in CH‐Aktivierungen
Authors: Paschai Darian Leon K. , Ballmann Joachim , Gade Lutz H. 
Published: November 2024

AbstractZwei T‐förmige 14‐Elektronen‐Rhodiumkomplexe, 2 a und 2 b, wurden durch PNP‐Pincer Liganden „eingerahmt“ und somit stabilisiert. Der Bis(t‐butyl)phosphin‐PNP‐Komplex 2 a wurde als stabilerer cyclometallierter Rh(III)‐hydrido‐Komplex aus Pentan isoliert, welcher sich im thermodynamischen Gleichgewicht mit dem T‐förmigen 14e− Rh(I)‐Komplex 2aT befindet, der selbst, bei Änderung des Lösungsmittels, direkt kristallisiert werden konnte. Die Cyclometallierung wird durch Verwendung des Adamantyl‐substituierten PNPAd‐Liganden unterdrückt, und die analoge T‐förmige Rh(I)‐Spezies 2 b erhalten, die durch eine agostische Wechselwirkung mit einem der Adamantyl‐C−Hs stabilisiert wird. Abhängig vom Lösungsmittel reagierte Komplex 2 a mit Ethylen entweder durch π‐Koordination (4 a) oder C−H‐Aktivierung, unter Bildung einer Hydrido‐Vinyl‐Rh(III)‐Spezies 4 b, wobei sich beide Isomere in Lösung im Gleichgewicht befinden. Komplex 2 b reagiert unter reversibler C−H Aktivierung mit Aromaten, wobei Hydrido‐Aryl‐Rh(III)‐Komplexe gebildet werden.
T‐shaped 14 Electron Rhodium Complexes: Potential Active Species in C−H Activation
Authors: Paschai Darian Leon K. , Ballmann Joachim , Gade Lutz H. 
Published: November 2024

AbstractTwo T‐shaped 14‐electron rhodium complexes 2 a and 2 b, “framed” and thus stabilized by PNP pincer ligands have been synthesized. The bis(t‐butyl)phosphine derived PNPtBu‐rhodium complex 2 a was isolated from pentane as the more stable cyclometalated Rh(III) hydrido complex and found to be in equilibrium with the T‐shaped 14e− Rh(I) complex 2 aT which itself could be directly crystallized upon change of the solvent. The cyclometallation is suppressed using an adamantyl substituted PNPAd ligand to give the analogous T‐shaped Rh(I) species 2 b, stabilized through an agostic interaction with one of the adamantyl C−Hs. Depending on the solvent, complex 2 a reacted with ethylene either by π‐coordination (4 a) or C−H activation giving a hydrido‐vinyl Rh(III) species 4 b, both isomers being in equilibrium in solution. Complex 2 b was found to reversibly C−H activate arenes to form the hydrido‐aryl Rh(III) complexes.
Sustainable Design and Revolutionary Synthesis of Highly Recyclable Sulfonic Acid–Based Magnetic Nanoparticles as a Solid Acid for Synthesis of 2‐Substituted Benzimidazole and Bis Indole Methane Derivatives
Authors: Alka  , Patel Upendra Kumar , Agarwal Alka 
Published: November 2024

ABSTRACTConcerning the objectives of green chemistry, silica‐coated magnetite nanoparticles provide a new way to implement an efficient and effective system for assisting catalyst recovery across multiple organic reactions. With Fe3O4 spheres serving as the core shell, the synthesis of sulfonic acid‐functionalized silica‐coated magnetic nanoparticles is presented in this paper. FTIR, PXRD, SEM, TEM, EDX, TGA, XPS, and VSM techniques were used to assess the prepared catalyst. The proposed nanocatalyst was employed to produce biological relevance 2‐substituted benzimidazole and bis indole methane derivatives. High yield, quick reaction time, soothing reaction conditions, extended functional group tolerance, and an accessible workup approach are the main advantages of synthesized nanoparticles. Furthermore, the present nanocatalyst may be recovered using an external magnet and retaining its effectiveness for up to six cycles. These are distinctive functions of the present approach.
A New Hetero‐Bimetallic [Fe(III)‐Mn(I)] Complex as a Dual Modality, Theranostic Tool for Photoactivated Anticancer Therapy
Authors: Panwar Abhishek , Upadhyay Aarti , Mukherjee Moubani , Chanu Phamdom Romabai , Roy Mithun 
Published: November 2024

ABSTRACTWe developed a novel hetero‐bimetallic Fe(III)‐Mn(I) complex by combining hydroxyl radicals generating Fe(III)‐Phenolato/Carboxylato and CO‐releasing Mn(I)(CO)3 complexes to achieve a dual‐modality theranostic tool for photoactivated anticancer therapy. Fe(III)‐Phenolato/Carboxylato and Mn(I)(CO)3 complexes were conjugated through the amide coupling to synthesize the bimetallic Fe(III)‐Mn(I) complex ([Fe‐Mn]) and characterized analytically and spectroscopically. Various photophysical assays have confirmed the production of hydroxyl radicals and the release of CO when the biologically benign [Fe‐Mn] complex is activated by visible light (400–700 nm), resulting in a significant increase in luminescence intensity. The cytotoxic potential of the complex, [Fe‐Mn] resulted from the photoactivated enrichment of ROS and CO in the A549 cells with the photoindex of ~35 leaving HPL1D cells unaffected. We probed the caspase 3/7‐dependent apoptosis and the theranostic potential of the complex, [Fe‐Mn] on photoactivation in vitro. The hetero‐bimetallic Fe(III)‐Mn(I) complex ([Fe‐Mn]) provides an ideal example of a dual‐modality next‐generation theranostic tool for photoactivated anticancer therapy.
Highly Active and Stereoselective Ring‐Opening Polymerization of Racemic Lactide Over HTGCP Catalysts
Authors: Mi Ansheng , Li Zhongwei , Wu Mengjie , Duan Wensheng , Qiao Congde , Yao Jinshui , Liu Qinze 
Published: November 2024

ABSTRACTDespite the extraordinary success has been achieved in metal catalyst‐promoted stereoselective ring‐opening polymerization (ROP) of rac‐lactide (rac‐LA), well‐controlled stereoselective rac‐LA ROP by organic catalyst still remains a scientific challenge. In this study, we showcase the remarkable ability of the phosphazene base 2,2,4,4,6,6‐hexa(tetramethyl‐guanidyl)‐1,3,5,2λ5,4λ5,6λ5‐cyclictri(phosphazene) (HTGCP) to facilitate the stereoselective ROP of rac‐LA at low temperatures, yielding isotactic stereoblock poly (lactic acid) (PLA) with a stereoselectivity index (P
m) up to 0.86. Furthermore, by harnessing the synergy between HTGCP and a (thio)urea, both high stereoselectivity (P
m up to 0.85) and remarkable catalytic activity (> 99% monomer conversion within an hour) can be achieved at ambient temperature. Notably, upon decreasing the temperature to −20°C, an even higher degree of regularity is attained (P
m up to 0.91). The direct linear correlation between molecular weights (M
n), monomer conversions, and the narrow dispersity (Đ) of the resulting polymers, coupled with their high end‐group fidelity, underscores the meticulous control exerted over the polymerization. Based on these findings, we propose that the chain end control mechanism underlies the synthesis of isotactic stereoblock PLA from rac‐LA in the presence of HTGCP, offering a novel and efficient pathway to produce high‐performance PLA materials.
Study on the Properties and Mechanism of m‐FACs/f‐Fe3O4/Epoxy Wear‐Resistant Magnetic Coating
Authors: Dai Ting , Chen Ping , Wang Gaoyu , Yang Weixu , Wang Chenggang , Xuan Lijian , Zhang Lu 
Published: November 2024

ABSTRACTIn view of the wear problem of key parts of magnetic fluid seal device, epoxy resin (EP) composite coatings reinforced with Fe3O4 and fly ash cenospheres (FACs) were fabricated successfully. The structural and morphological features of the fillers and the composite coatings were characterized by Fourier transform infrared and scanning electron microscopy. CFT‐I material surface performance comprehensive tester was used to investigate the tribological behaviors of the as‐prepared composite coatings. Vibrating sample magnetometer was used to investigate the coatings' magnetic property. The formation mechanism of the composite coating was analyzed by the infrared spectrum results combined with molecular dynamics simulations. The results demonstrated that adding a certain amount of double fillers will have a synergistic effect, and its mechanical properties are better than those of single fillers. The tribological property of the m‐FACs/f‐Fe3O4/EP composite coatings was optimal under magnetic fluid friction, which is about an order of magnitude lower than the wear rate under dry friction. The saturation magnetization of the m‐FACs/f‐Fe3O4/EP composite coating is 2.77 emu/g, and the magnetic susceptibility reaches 4.64 × 10−4 m3/kg. Therefore, the m‐FACs/f‐Fe3O4/EP composite coating will be expected to solve the wear problem of equipment components in complex environments of magnetic field and friction.
Piperine‐Loaded Sodium Caseinate Nanoglobules Delivered Transdermally Through Microneedle Patch for Improved Bioavailability at Adipose Tissue
Authors: Mudhol Seema , Serva Peddha Muthukumar 
Published: November 2024

ABSTRACTDespite being a well‐known anti‐obesity chemical, piperine has only found limited therapeutic use because of its poor bioavailability at the site of action. In order to test this hypothesis, we placed piperine sodium caseinate nanoglobules (PSN) in microneedle patches (MNPs), which may enhance piperine transdermal delivery and absorption. Clove oil, sodium caseinate to make nanoglobules, and PEG 400 as a stabilizer were used in a nanoglobules process to create the PSN. The polydispersity index (0.256) and particle size (134.4 nm) of the developed PSN were both smaller, while their zeta potential (−44.4 mV) and encapsulation efficiency (90%–95%) were both greater. Compared to native piperine, the PSN increased solubility, bioaccessibility (6.5 times), and bioavailability (2.8 fold). Moreover, the PSN‐loaded MNPs were created using the micro‐molding (poly‐dimethylsiloxane (PDMS) mold) approach. In both PBS buffer and porcine skin, the PSN‐loaded MNPs were rapidly hydrolyzed, with 50% piperine release in less than 5 min. Also, the produced MNPs demonstrated improved bioavailability of piperine in the plasma (180 ng/mL) and adipose (425 ng/mL) tissue of C57BL6 mice. In conclusion, the work offered a theoretical foundation for utilizing new PSN‐loaded MNPs as a viable piperine delivery method for treating obesity.
Autistic adults exhibit a typical search advantage for facing dyads
Authors: Vestner Tim , Gehdu Bayparvah Kaur , Gray Katie L. H. , Cook Richard 
Published: November 2024

AbstractRecent findings obtained with non‐autistic participants indicate that pairs of facing individuals (face‐to‐face dyadic targets) are found faster than pairs of non‐facing individuals (back‐to‐back dyadic targets) when hidden among distractor pairings (e.g., pairs of individuals arranged face‐to‐back) in visual search displays. These results suggest that facing dyads may compete for observers' attention more effectively than non‐facing dyads. In principle, such an advantage might aid the detection of social interactions and facilitate social learning. Autistic individuals are known to exhibit differences in visual processing that impede their perception of other individuals. At present, however, little is known about multi‐actor visual processing in autism. Here, we sought to determine whether autistic individuals show a typical search advantage for facing dyads. In an online study, autistic and non‐autistic participants were tasked with finding target dyads (pairs of faces arranged face‐to‐face or back‐to‐back) embedded among distractor dyads (pairs of faces arranged face‐to‐back). Relative to the non‐autistic controls, the autistic participants took slightly longer to locate target dyads. However, a clear and comparable search advantage for facing dyads was seen in both participant groups. This preliminary evidence suggests that multi‐actor processing of autistic participants exhibits typical sensitivity to dyadic arrangement.
Increasing Water Supply Resilience Through the Pure Water Antelope Valley Program
Authors: Rogers Scott , Hirani Zakir 
Published: November 2024

Key TakeawaysThe Pure Water Antelope Valley (AV) program, the first inland potable reuse program in California, aims to augment water supplies to overcome current and projected reductions.Pure Water AV will use groundwater recharge via subsurface injection to increase the reliability and resilience of Antelope Valley's water supply.A collaboration between the Palmdale Water District, City of Palmdale, and Los Angeles County Sanitation Districts, the program will improve the groundwater quality over time.Besides overcoming technical challenges, Pure Water AV's success depends on well‐thought‐out strategies for funding and public outreach.