bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the impact of deglaciation on fault slip in the Sangre de Cristo Mountains, Colorado, USA
Authors: Hurtado Cecilia , Gallen Sean F. 
Published: November 2024

Abstract
Few natural examples exist where climate’s influence on tectonics is clear. Based on a study of the Sangre de Cristo Mountains in southern Colorado, we argue that climate-driven changes in ice loads affected spatial and temporal slip patterns on the range-front normal fault. Relict glacial features enable the reconstruction of paleoglacier extents and show variable amounts of footwall ice coverage during the Last Glacial Maximum (LGM). Line load models indicate post-LGM ice melting reduced fault clamping stress by ~20–55 kPa at seismic depths. Flexural isostatic modeling shows several meters of footwall uplift due to ice unloading with spatial patterns and magnitudes consistent with post-LGM fault throw measured from offset Holocene and late Pleistocene alluvial fans. Post-LGM fault throw rates are at least a factor of five higher than middle and early Pleistocene rates. We infer that climate-modulated ice-load changes can pace fault clamping stress and slip patterns on range-bounding normal faults.
Differences in the pathological, transcriptomic, and prognostic implications of lymphoid structures between primary and metastatic cutaneous melanomas
Authors: Karapetyan Lilit , Li Aofei , Vargas De Stefano Danielle , Abushukair Hassan M , Al-Bzour Ayah N , Knight Andrew , Layding Caroline , Wang Hong , Xu Jin , Yao Jiqiang , Song Xiaofei , Joy Marion , Nguyen Jonathan , Moran-Segura Carlos , Bruno Sabrina , Sander Cindy , Messina Jane , Mule James J , Storkus Walter J , Kirkwood John M 
Published: November 2024

BackgroundWhile the prognostic role of tertiary lymphoid structures (TLS) has been well studied in solid cancers, the prevalence and impact of immature precursor lymphoid structures known as lymphoid aggregates (LA) remain unresolved in relation to the disease process. In this study, we examined characteristics and the prognostic utility of LA and TLS status in histological samples from patients with melanoma.MethodsWe assessed The Cancer Genomic Atlas-skin cutaneous melanoma digital slides and melanoma specimens from the University of Pittsburgh for the presence of LA and TLS using H&E staining, multiplex immunofluorescence (mIF) and transcriptomic analyses. Cox proportional hazard regression models were used to assess the prognostic value associated with the presence of lymphoid structures in melanomas.ResultsA total of 278 evaluable samples were analyzed and split into primary melanomas in skin (N=195) and metastatic melanomas involving skin/subcutaneous/soft tissue sites (N=83). 72% of tumor specimens contained histologically defined LA located in peritumoral (34%), intratumoral (5.6%) or stromal (6.1%) locations, with the remaining samples (54.3%) exhibiting LA in multiple locations. In contrast to LA which tended to form more commonly in primary melanoma samples, TLS with germinal centers predominantly formed in peritumoral (45.2%) or stromal (35.5%) locations in metastatic melanomas (p=0.02), with TLS observed in 11% of all melanoma specimens evaluated. mIF analyses revealed cellular heterogeneity of lymphoid structures, with CD20+(B) cells present in nodule-shaped and stromal locations where they exhibited a high degree of colocalization with CD4+and CD8+T cells. A previously defined 12-chemokine gene expression score was significantly higher in samples with evidence of LA versus none (p<0.001), and samples without LA/TLS were enriched with pigmentation/neural network gene signatures. The presence of LA was significantly associated with tumor-free regional lymph node status (p=0.002). In multivariable analysis, after adjusting for age, sex, sample type, and stage, the presence of LA was associated with improved patient overall survival (OS) (HR=0.52, 95% CI 0.31 to 0.87, p=0.01).ConclusionMelanoma frequently contains LA, which tends to form in diverse locations in the tumor microenvironment in association with improved overall survival and tumor-free regional lymph node status in patients with primary disease.
Seasonality and interannual variability of an Arctic marine time series, IsA
Authors: Vader Anna , Handler Eleanor , Skogseth Ragnheid , Larsen Aud , Gabrielsen Tove M. 
Published: November 2024

The Arctic is warming twice as fast as anywhere else on the planet, in the European Arctic mainly driven by exalted Atlantic Water inflow. Microbial eukaryotes are diverse and essential to the functioning of marine ecosystems, thus environmental perturbations altering their communities influence the entire ecosystem. To study seasonal and interannual variation and the potential effects of Atlantification, a long-term marine time series has been established in Isfjorden-Adventfjorden, West Spitsbergen. We here present 3 years of high-resolution data including hydrography, nutrients, photosynthetic biomass, flow cytometry and community composition of microbial eukaryotes (0.45–10 µm, based on Illumina metabarcoding of 18S rDNA and rRNA). The timing, magnitude and species composition of the spring bloom varied interannually, with the more Atlantic spring 2014 being distinctly different from the two other years. A strong recurring seasonal pattern was evident in biodiversity, cell abundances and community composition. Winter communities were characterized by high alpha diversity and very low cell numbers with a dominance of heterotrophic and parasitic taxa. Despite large intra- and interannual differences in communities during the productive time of the year, winter communities were always highly similar, suggesting that the polar night represents a strong environmental forcing that resets the microbial communities.
Youth COVID-19 stressors and associations with self-perceived health, depression, anxiety, and at-risk alcohol and cannabis use
Authors: Afifi Tracie O. , Fortier Janique , Salmon Samantha , Taillieu Tamara , Osorio Ana , Roos Leslie , Stewart-Tufescu Ashley , Tonmyr Lil , Gonzalez Andrea , Kimber Melissa , Sareen Jitender , MacMillan Harriet L. 
Published: November 2024

Adolescents and young adults have been particularly vulnerable to disruptions caused by the COVID-19 pandemic. The objectives were to identify youth's self-reported pandemic-related stressors and examine how these stressors were related to six negative health outcomes: self-perceived, fair-to-poor physical, and mental health, depression, anxiety, and at-risk alcohol and cannabis use. Data were from the Well-Being and Experiences Study (The WE Study) from Manitoba, Canada (17–22 years old; n = 587; collected from November 2021 to January 2022). The COVID-19 stressors reported most frequently since pandemic onset included: (1) not being able to spend time with friends (78.5%); (2) feeling lonely or isolated (69.9%); and (3) remote learning for school, college, or university (68.4%). In reference to the “past month”, frequently reported stressors were (1) remote learning (42.6%); (2) feeling lonely or isolated (41.2%); and (3) uncertainty about the future (41.1%). Overall, 26.1% of the sample perceived their physical health as fair-to-poor and 59.1% perceive their mental health as fair-to-poor. A number of stressors were related to fair-to-poor mental health, depression, and anxiety; fewer were related to fair-to-poor physical health and at-risk alcohol and cannabis use. These findings can inform future pandemics and recovery efforts to improve pandemic-related health risks among youth.
Integrating Network Pharmacology and Metabolomics to Explore the Potential Mechanism of β‐Sitosterol Against Hyperuricemia Nephropathy
Authors: Yang Fan , Sun Lu , Gao Yingjie , Liang Jingzhen , Ye Wenqian , Yang Wenjing , Xie Siyi , Zhou Jiangtao , Li Rongshan 
Published: November 2024

Background: Renal involvement resulting from hyperuricemia, known as hyperuricemia nephropathy (HN), is characterized by chronic tubulointerstitial inflammation caused by extensive urate crystal deposition. Managing this condition requires straightforward preventive or therapeutic interventions, primarily through dietary measures.Methods: In this study, the mouse model of HN was established using yeast extract combined with potassium oxonate. The effect and potential mechanism of β‐sitosterol in treating HN were investigated through biochemical indexes, pathological changes, untargeted metabolomics, and network pharmacology.Results: β‐Sitosterol reduced the levels of four biomarkers of HN: uric acid (UA), creatinine (CRE), blood urea nitrogen (BUN), and xanthine oxidase (XOD). It also mitigated inflammatory injury in renal tissues and reversed the abnormal expression of four key urate transporter proteins: glucose transporter protein 9 (GLUT9), organic anion transporter 1 (OAT1), ATP‐binding cassette transporter G2 (ABCG2), and urate transporter 1 (URAT1). To explore the mechanism of β‐sitosterol in treating HN, this study employed network pharmacology and metabolomics to analyze 27 intersecting gene targets and 14 differential metabolites. The findings indicated that glutathione (GSH) metabolism might be a crucial pathway. Treatment with β‐sitosterol increased the levels of reduced GSH as well as the activity and expression of 6‐phosphogluconate dehydrogenase (G6PDH) in mice, thereby effectively modulating GSH metabolism. This study proposes a novel strategy using β‐sitosterol for treating HN, providing a promising approach for addressing this condition.
Application of Titanium Mesh in the Early Treatment of Flail Chest
Authors: Liu Gaofeng , Zhou Li , Li Chen , Cao Junying , Zhang Yong , Cui Sujuan , Liu Yan , Xu Yanbin , Zang Yongjie , Yang Meiming , Li Qingyuan 
Published: November 2024

Objective: To investigate the effect of the titanium mesh on flail chest and bone healing from clinical and animal experiments.Methods: Clinical experiment: 24 patients with flail chests in our hospital from January 2020 to January 2023 were prospectively selected and divided into control and titanium mesh groups according to different treatment plans and basic data‐matching principles, with 12 cases in each group. The control group was treated with conservative external fixation, and the titanium mesh group was treated with titanium mesh fixation. The clinical efficacy index, visual analog scale and blood gas indexes and hemodynamic indexes of the two groups of patients were recorded. Chest CT and pulmonary function and life quality were examined after operation. Animal experiment: The flail chest sheep were treated conservatively with a titanium mesh, and the expression of bone‐healing‐related proteins was detected.Results: The mechanical ventilation time, drain indwelling time, ICU observation time, and hospital time in the titanium mesh group were significantly shorter than those in the control group (p < 0.05). The PaO2, CVP, FVC, FEV1, MVV, and life quality of the titanium mesh group were significantly better than those of the control group after operation, and the visual analog scale, PaCO2, CI, ELWI, and the proportions of atelectasis, thoracocyllosis, and consolidation tardive after operation were significantly lower than those of the control group (p < 0.05). The expressions of BMP2, IGF‐1, VEGF, and PDGFD in the rib tissue of titanium mesh sheep were higher than those of control sheep at 4 weeks after operation (p < 0.05).Conclusion: Titanium mesh is a safe and effective treatment for flail chest, which can improve pain, blood gas, hemodynamic indexes, and pulmonary function and promote fracture healing.
Dysmenorrhea and Occupational Factors
Authors: Jung Heeja , Dan Hyunju , Cha Chiyoung , Pang Yanghee 
Published: November 2024

Aim: To examine the prevalence of dysmenorrhea in the predominantly female nursing profession and investigate the role of occupational characteristics in dysmenorrhea.Background: Studies on working women have mostly examined the effects of dysmenorrhea symptoms on work performance, as opposed to shedding light on the association between work‐related characteristics and dysmenorrhea.Methods: In this cross‐sectional study, we used data obtained from survey 9 of the Korea Nurses’ Health Study. The participants were female nurses of childbearing age. Statistical analysis included descriptive statistics and multivariable logistic regression.Results: Data from 6697 participants were analyzed. Of the total sample, 47.3% had dysmenorrhea. After adjusting for confounders to examine the relationship between occupational characteristics and dysmenorrhea, the odds for dysmenorrhea were 1.230 times higher among women who lifted heavy objects at least six times a day compared to those who did not engage in heavy lifting (95% confidence interval: 1.028–1.473) and 1.042 times higher among women with higher physical fatigue (odds ratio: 1.042, 95% confidence interval: 1.023–1.061).Conclusion: The findings clarify the potential for reducing dysmenorrhea through the improvement of work environment factors. Thus, this study may prove useful for developing educational programs and policies that aim to alleviate dysmenorrhea among working women, including nurses.Implications for Nursing Management: Nursing managers and health policymakers need to understand the factors influencing dysmenorrhea and minimize female nurses’ physical burden by implementing appropriate nurse–patient ratios and improving their work environment.
Mammographic Density in Relation to Breast Cancer Risk Factors among Chinese Women
Authors: Koka Hela , Tian Yuan , Deng Lu , Yu Kai , Li Er-Ni , Guo Changyuan , Guida Jennifer L. , Sung Hyuna , Chan Ariane , Hu Nan , Lu Ning , Gierach Gretchen L. , Li Jing , Yang Xiaohong R. 
Published: November 2024

Abstract

Background:
Increased mammographic density (MD) is a known breast cancer risk factor, but its influencing factors are unclear in Asian populations. This study examined the links between known breast cancer risk factors and quantitatively measured MD in 7,351 Chinese women with nonmalignant mammographic findings.

Methods:
VolparaDensity software quantified volumetric MD measures: total breast volume (TBV), absolute dense volume (ADV), percent dense volume (PDV = ADV/TBV), and nondense volume (NDV = TBV − ADV). Multivariable linear regression models assessed associations between these MD metrics and breast cancer risk factors.

Results:
The mean age of the population was 50.1 (SD = 8.3) years. The mean ADV, NDV, and PDV were 58.4 cm3 (SD = 32.1), 382.8 cm3 (SD = 202.0), and 14.8 % (SD = 7.1), respectively. PDV was inversely associated with age, weight, body mass index (BMI), parity, breastfeeding duration, and postmenopausal status but positively linked to height and age at menopause. NDV showed opposite associations. ADV had similar associations to PDV, except for height, weight, and BMI, which differed for women with the lowest NDV. PDV associations with age at menarche, age at first birth, and breastfeeding duration varied by BMI and menopausal status.

Conclusions:
MD may influence the relationships between reproductive factors and breast cancer risk, depending on MD measure, menopausal status, and BMI.

Impact:
This study examines how quantitative MD measures relate to known breast cancer risk factors in an East Asian population, factoring in menopausal status and BMI. The results underscore the complex role of MD and confounding factors in breast cancer risk, highlighting the need for tailored insights for future research and screening.
Abstract B038: Application of Liquid Biopsy-RECIST (LB-RECIST) criteria to track metastatic colorectal cancer (mCRC) molecular response in first-line (1L) setting: Findings from the PLATFORM-B study
Authors: Martelli Valentino , Vidal Joana , Fernández-Rodríguez Maria Concepción , García-Alfonso Pilar , Páez David , Gibert Joan , Linares Jennifer , Sibilio Annarita , Alonso Vicente , Cano Maria Teresa , Santos Cristina , Duran Gema , Élez Elena , Manzano José Luis , Garcia-Carbonero Rocio , Ferreiro Reyes , Losa Ferran , Pineda Estela , Sastre Javier , Gomez-España Auxiliadora , Toledo Rodrigo , Rivera Fernando , Bellosillo Beatriz , Tabernero Josep , Salazar Ramon Ramon , Aranda Enrique , Montagut Clara 
Published: November 2024

Abstract
This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR009) of the Conference Program/Proceedings.
Citation Format: Valentino Martelli, Joana Vidal, Maria Concepción Fernández-Rodríguez, Pilar García-Alfonso, David Páez, Joan Gibert, Jennifer Linares, Annarita Sibilio, Vicente Alonso, Maria Teresa Cano, Cristina Santos, Gema Duran, Elena Élez, José Luis Manzano, Rocio Garcia-Carbonero, Reyes Ferreiro, Ferran Losa, Estela Pineda, Javier Sastre, Auxiliadora Gomez-España, Rodrigo Toledo, Fernando Rivera, Beatriz Bellosillo, Josep Tabernero, Ramon Ramon Salazar, Enrique Aranda, Clara Montagut. Application of Liquid Biopsy-RECIST (LB-RECIST) criteria to track metastatic colorectal cancer (mCRC) molecular response in first-line (1L) setting: Findings from the PLATFORM-B study [abstract]. In: Proceedings of the AACR Special Conference: Liquid Biopsy: From Discovery to Clinical Implementation; 2024 Nov 13-16; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2024;30(21_Suppl):Abstract nr B038.
A violência física nas relações conjugais no município de Vitória: uma análise das denúncias da delegacia especializada em atendimento à mulher em 2015
Authors: Carvalho Bruna Passos 
Published: November 2024

Gender violence is the result of the social relations of male domination and female submission, built, millenary, by a patriarchal system. From 1980, however, in the fervor of brazilian feminist movements, the Delegacia Especializada em Atendimento à Mulher (DEAMs) were created with the objective of combating this violence, which can occur in different ways and has become the object of study of research. aimed at improving public policies in the country. Using as a primary source the police reports registered in the DEAM of the city of Vitória in 2015, this article aimed to investigate the relation between the permanence of physical and conjugal violence and a capixaba society molded from patriarchal principles.
Abstract 4127345: National Cohort Study on Hypertensive Disorders of Pregnancy Among Women with Congenital Heart Disease: Insights from Multiple Centers
Authors: Zhang Qian , Zhu Fang , Zhu Chunfeng , Ma Ruixiang , Miao Huixian , chen huiwen 
Published: November 2024

Background:
Hypertensive disorders of pregnancy (HDP) are among the primary reasons for maternal and perinatal deaths globally. Encompassing chronic hypertension, pregnancy induced hypertension (PIH), and preeclampsia, HDP are among the most frequent complications encountered during pregnancy. Considering the emerging congenital heart disease (CHD) population globally, research on HDP in pregnancies with CHD is urgently needed.

Methods:
Outcomes for 2220 pregnant women with CHD were evaluated retrospectively from 1993 to 2016 and prospectively from 2017 to 2019 from 7 tertiary hospitals. Maternal death, cardiac complications, obstetric and offspring complications of completed pregnancies and their demographics, cardiac characteristics, and comorbidities were collected. To identify the risk factors for HDP, univariate and multivariate analysis were performed through logistic regression.

Results:
Of 2220 completed pregnancies with CHD from 7 tertiary institutions, 77 women had PIH, and 76 women had preeclampsia. The main CHD diagnosis of patients with PIH was shunt lesion (including ASD, VSD, and PDA), left heart abnormality (including AS/AI, BAV, and COA), and single ventricle (SV). The main CHD diagnosis of patients with preeclampsia was shunt lesion (including ASD, VSD, and PDA), left heart abnormality (including AS/AI and MS/MI), and right heart abnormality (including TOF, PS/PAS/PI, DORV and DCRV).

In parturients with PIH, the mortality and incidence of heart failure were 2.60% and 15.58%, respectively. In parturients with preeclampsia, the mortality and incidence of heart failure were 6.58% and 23.68%, respectively. Pregnancies with HDP had a significantly higher incidence of adverse maternal and offspring events than pregnancies without HDP.
Independent risk factors for HDP included multiple gestation, use of medically assisted reproduction, having elevated brain natriuretic peptide (BNP) level, delayed first ANC visit, and absence of strict antenatal supervision.

Conclusion:
In summary, the presence of HDP in women with CHD significantly increased the risk of mortality and morbidity for both the mother and the child, particularly in cases involving preeclampsia.
Abstract 4131796: Non-Contact Biometric System for Early Detection of Hypertension and Diabetes Using AI and RGB Imaging
Authors: Uchida Ryoko , Chen Ying , Hasumi Eriko , Fujiu Katsuhito 
Published: November 2024

Introduction:
In recent years, the development of wearable devices and bioinformation analysis applications utilizing smartphone sensors has seen significant advancements. Despite these technological strides, their adoption and sustained use remain limited to health-conscious individuals. The general populace, particularly those indifferent to health management, stands to miss out on the potential benefits of wearable technologies due to a lack of engagement. This disconnect underscores the necessity for more accessible health monitoring solutions.

Research Questions and Goals:
This study aims to bridge the gap in health monitoring accessibility by introducing a system capable of non-invasive, non-contact acquisition of biometric information. Such a system seeks to democratize the early detection and prevention of diseases across various demographics.

Methods and Results:
A prospective cohort clinical study was conducted in a hospital setting with approximately 200 consenting patients and healthy controls. Images of the subjects' faces and hands were captured with a high-speed camera, and blood pressure measurements were taken simultaneously for correlation.

A machine learning algorithm was developed to analyze skin blood flow and spectral features from these images to identify potential diseases. The study specifically focused on early detection of hypertension and diabetes. Hypertension was categorized for individuals with systolic blood pressure ≥115 mmHg or diastolic blood pressure ≥75 mmHg. Diabetes was identified in subjects with HbA1c levels ≥6.5 or those previously diagnosed.
The algorithm's performance in detecting hypertension showed a 94.2% in alignment with the AHA guidelines for stage1 hypertension, based on pulse wave features. For a subset including 40% early hypertension cases, accuracy rates were 86.2% for 30-second data segments and 80.9% for 5-second segments.
For diabetes detection, the application of the algorithm to video data achieved a 75.3%, utilizing blood flow patterns as markers. Hypertension and diabetes were analyzed using different features.

Conclusions:
The integration of AI algorithms with video data analysis of skin and blood vessels demonstrates a promising avenue for the non-contact, early detection of hypertension and diabetes. This approach not only offers a viable non-contact monitoring technology, but also represents a significant leap towards inclusive, accessible health care prevention and management strategies.