bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRUCTURE OF TOOTH RUDIMENTS AND MINERAL METABOLISM PATTERN AT VIBRATION EFFECTIN THE EXPERIMENT
Authors: Апраксина Елена , Apraksina Elena , Залавина Светлана , Zalavina Svetlana , Жлезный Павел , Zhelezny Pavel , Железаня Анна , Zheleznaya Anna 
Published: August 2018

Object. Vibration exposure is the most common adverse technogenic factor in the work and living conditions of many people. A significant impact on the state of the oral cavity have many socio-hygienic factors; the nature of their impact, their variability depends on the individual, the environmental situation in the region, the social conditions of people, as well as their professional activities. The undeniable fact is that production factors have an impact on both somatic health and dental status. These circumstances explain the importance of studying the development of the structure of dental rudiments, taking into account the mineral metabolism in the conditions of various anthropogenic influences, including the action of General industrial vibration.
Purpose of the study. Explore features of the histogenesis of teeth based on mineral metabolism during vibrational excitation.
Materials and methods. Wistar rats was performed with a vibration 9 to day 18 of pregnancy. We studied the morphology of the tooth germs in the fetus. Analytical studies of the mineral composition of the liver were performed by IRS-nuclear laboratory NGO "CBM" (Moscow) in the method of Dr. A.V. Skalniy. In the liver, the concentration female elements: Ca, Cd, Cu, Fe, Mg, P, Pb, Se, Zn.
Results. The features in the structure of tooth germs and mineral metabolism in the mother-fetus system with vibrational excitation. Identified structural changes reveal a violation of microcirculation, the development of hypoxia in the tissues of the tooth germ and accelerated dentinogenesis. Change the concentration of minerals in the body - significantly reduces the concentration of essential elements of Ca, Fe, Mg and significantly increased the content of Cu, Cd, Pb.
Conclusion. The observed changes in the morphology of tooth germs and mineral metabolism, are a reflection of altered homeostasis system the mother-fetus arising under the influence of vibration exposure.
EFFICIENCY OF THE COMPLEX OF THERAPEUTIC ACTIVITIES OF CHRONIC GYNGIVITIS IN PATIENTS WITH CHRONIC GASTRODUODENITE
Authors: Кабирова Миляуша , Kabirova Milyausha , Герасимова Лариса , Gerasimova Larisa , Каримова Сафия , Karimova Safiya , Баширова Татьяна , Bashirova Tatyana , Чемикосова Татьяна , Chemikosova Tatyana 
Published: August 2018

Subject. The article presents clinical, biochemical, immunological and microbiological results of a complex of therapeutic measures of chronic gingivitis in patients with chronic gastroduodenitis.
The aim of the study was to study the effectiveness of treatment of chronic gingivitis in patients with chronic gastroduodenitis with the use of the proposed method.
Methodology. The subject of the study was 155 persons aged 19 to 25 years with diagnosed chronic gingivitis and chronic gastroduodenitis, which were divided by stratified randomization into three groups: 1 group (primary) - 52 patients; 2 group (positive control) - 52 patients; Group 3 (negative control) - 51 patients. All groups were comparable in age (F = 2,355, p = 0,092) and sex (χ2 = 2,133, p = 0,334).
To study the state of free radical oxidation, the method of chemiluminescence (CL) of the oral liquid was applied on the device HL-003. The quantitative and qualitative content of oral microflora was determined using nutrient media: CHROMagar Orientation, CHROMagar Candida (France). The concentration in the oral fluid of the intercellular adhesion molecules sICAM-1 was carried out on the automatic enzyme immunoassay analyzer Lazurit and test systems manufactured by Vector-Best CJSC (Russia) and eBioscience (Austria).
Results. The use of the complex proposed by us significantly improved the parameters of the clinical examination (dental indices). In addition, the state of free-radical oxidation has normalized: at previously increased values of the light-emission sum (S) and its maximum value (I max), during the time of the study, their decrease occurred, while the lowered values - the increase to the level of normal values. The level of microorganisms of the orange and red complex decreased to normal levels, and the level of sICAM-1 also significantly decreased.
Conclusions. The scheme of treatment of chronic gingivitis with the use of NUTRIEL with laminaria and tooth elixir with chlorophyll in patients with chronic gastroduodenitis led to an increase in the duration of remission compared with the traditional treatment regimen.
FEATURES OF REGENERATION OF BONE TISSUE IN THE PERIAPICAL ZONE OF THE REPLANTED TEETH
Authors: Иващенко Александр , Ivashchenko Alexander , Федяев Игорь , Fedyaev Igor , Яблоков Алексей , Yablokov Aleksey , Баландин Егор , Balandin Egor 
Published: August 2018

Subject. In this article, the problem of integrating the repaid teeth has been studied. Data on the fibroosteointegration of the replanted teeth were obtained on the basis of clinical and additional research methods.
Goal. To study the features of the regeneration of bone tissue in the periapical zone of the implantable teeth.
Methodology. The patient, C., 41, complained of a partial absence of teeth. As a result of examination of the mouth and analysis of the orthopantomogram, significant destruction of the crown part of the teeth of the upper and lower jaws was revealed. Based on the data obtained, a decision was made to remove them with subsequent replantation. Three months after the implantation, an orthopantomogram was performed. According to the data of roentgenography, uniform filling of the root canal with cement along the entire length was revealed, trabecular bone tissue in the region of the tips of the roots of the resplanted teeth is consistent. With the support of the implantable teeth, non-removable cermet structures were installed. Later, prosthetics was performed with removable orthopedic prostheses.
Results. After 2 years as a result of a follow-up examination, there was no pathological mobility in the resplanted teeth, the patient did not present any complaints. On intraoral virological images of the teeth 1.1, 1.2, 1.3, 3.4, the trabecular bone tissue in the projection of the apex of the roots is consistent, the inflammatory foci are not revealed. On the whole surface of the roots of the teeth 1.1-1.3 periodontal space can be traced throughout the root. Bone tissue in the region of the roots of these teeth without pathology. This observation may allow us to make an assumption about fibroosteointegration of these teeth.
Conclusions. Based on the results of the treatment and analysis of X-ray data from two-year follow-up, we found no abnormal mobility in the resplanted teeth, bone tissue in the apex of these teeth is well-founded, orthopedic structures supported by the resplanted teeth are stable.
Cu/Zn superoxide dismutase enzyme immunoreactivity in the stomach tissue of rats fed with mussels (Mytilus galloprovincialis)
Authors: MURATLI Aslı , GEZEN Mehmet Rıza 
Published: August 2018

Objectives: Mussels accumulate heavy metals in their tissues.
Although there are few data about the toxicity of seafood that is exposed to
environmental pollution, there are no animal studies about the gastric toxicity
of mussels grown in the Dardanelles. The antioxidant Cu/Zn superoxide dismutase
(Cu/Zn SOD) enzyme catalyzes the hydrogen peroxide dismutation of superoxide
radicals and removes the effects of free radicals which cause oxidative stress.
The purpose of the study was to demonstrate the Cu/Zn SOD in the stomach
tissues of rats which are fed with mussels that are collected from the Çamburnu
region of the Dardanelles. Methods: A total of 24 male Wistar albino rats were randomly divided into four
groups: Group 1 (n = 6), control group fed with standard rat food; Group 2 (n =
6), 75% mussels and 25% standard rat food daily; Group 3 (n = 6), 75% mussels
and 25% standard rat food every two days; and Group 4 (n = 6), 75% mussels and
25% standard rat food every three days. To detect Cu/Zn SOD localization in the
tissues, the LAB-SA Detection System was used. Results: Cu/Zn SOD enzyme immunoreactivity was not detected in Group 1 and in
samples without Cu/Zn SOD primer antibody. Cu/Zn SOD enzyme immunoreactivity
was detected 82% in Group 2, 79% in Group 3, and 61% in Group 4. There was
statistically significant difference between the Cu/Zn SOD immunoreactivity of
epithelial cells in the gastric mucosa of the rats in the experimental and
control groups (p &lt; 0.05). Conclusions: Determination of the increase of Cu/Zn SOD enzyme in
the gastric mucosa of mussel-fed rats that we used in our study suggests that
it triggers the antioxidant defense mechanism against mussel toxicity.
From Civilization Cradle with Rural Character to Value Based Urbanization Spectrums: Bursa-İznik Urban Design Studio Course
Authors: KOÇ Ersan 
Published: August 2018

This study was carried out in order to evaluate the findings of the studio "Studio upm+T: urban/public/mixed use + Transformation" which was carried out by the author in autumn and spring semesters of 2016-2017, together with the participants in the attached file and the contributors in the process of Kocaeli University Faculty of Architecture and Design. The aim of this study is to develop urban design and transformation projects with the aim of bringing high public values in the middle and long term to the city by considering urban design Bursa-İznik City as a workshop. The focus of the workshop is on identifying, evaluating, analyzing, synthesizing, developing the theme and developing the "Public Space" and "Common Area" and adding "Value" to the Iznik City Image. The examination of the workshop was coordinated among topics: " a. cultural and historical basis, b-natural and environmental resources, environmental planning and design, c- social and economic formation and dynamics, and d-spatial structure: settlement texture and settlement plan. Throughout the İznik Urban Design Workshop, 5 sociospatial concepts that feed the whole process were handled and it was aimed to feed the development and urban development opportunities that stand out for İznik. These concepts have been evaluated as "use value, change value, design value, memory-space and contrast-harmony. Furthermore, the approaches to be followed in order to get acquainted with new identities and to pass the visions to the practice have been determined by giving the 3 cities and regional vision "agriculture city, tourism city and culture city" concept. The gola of the paper is to portray a set of urban design schemes, which aimed to develop spatial contexts that will positively serve and contribute to the quality of life of the city within the practice of urban design known as a common professional practice area of Urban and Regional Planning, Architecture and Landscape Architecture.
Reflection of Preservice Teachers’ Thoughts about Connecting Mathematics and Real Life Situations on Their Mathematics Learning Activities
Authors: YİĞİT KOYUNKAYA Melike , UĞUREL İşıkhan , TATAROĞLU TAŞDAN Berna 
Published: August 2018

The importance of constructing connections has been emphasized in many academic works, learning models, standards and teaching programs that illuminates teaching and learning of mathematics. In addition to the connection, the importance of a learning unit which is named as activity has been emphasized in many recent works and thoughts related to teaching and learning of mathematics. This situation moves the activities and activity based learning into the center of mathematics education. In mathematics education, mathematics learning activities are the most appropriate learning unit that could be construct connections with it. In this context, it is thought that it would be beneficial to explain what the connection is and how to construct connection using the existing or developed activities. The main purpose of this study is to identify pre-service secondary mathematics teachers’ (PSMTs) thoughts about what the real life connection is and how this connection could be constructed, and to examine how PSMTs reflected their thoughts on a group of mathematics learning activities that are connected with real life situations. In this work, the case study, which is one of the qualitative research paradigms, was used. The study was conducted with 33 (11 group) PSMTs who had been educated for 4th years in a public university. The PMSTs were asked to write free writings related to what the real life connection is and how to construct real life connections and to develop mathematics learning activities that are connected with real life situations. The collected data was analyzed using content analysis method. It is found that while PSMTs defended the necessity and importance of the real life connection, they had difficulty in reflecting this on mathematics learning activities.
Poslolitismo: el legado de Lolita en el cine indie del siglo XXI = Post-lolitism: the Lolita’s Legacy in the XXI’s Indie Cinema
Authors: León Arima 
Published: August 2018

Resumen. En este trabajo realizo un recorrido a la inversa desde las películas La Belle Personne (Christophe Honoré, 2008), Fish Tank (Andrea Arnold, 2009) y The Diary of a Teenage Girl (Marielle Heller, 2015), hasta llegar a su germen: Lolita (1955), novela escrita por Vladimir Nabokov y adaptada a la gran pantalla por Stanley Kubrick en 1962. A partir de esta conexión, analizo los aspectos definitorios de esta nueva poslolita, enmarcando el personaje en un viaje narrativo concreto y un discurso feminista consciente. El viaje consta de tres momentos clave: una primera toma de contacto, el encuentro sexual y la liberación de la situación de opresión. En cuanto al discurso feminista, este revisa la figura de las poslolitas como objeto de deseo, además de la relación con el adulto y la iniciación sexual de las jóvenes. Estas tres películas suponen la reinterpretación del mito que Kubrick crea en su filme. Asimismo, esta nueva lectura del lolitismo se entiende a partir de la apropiación femenina de un discurso que ha sido explotado casi en exclusivo por hombres. Esto, sumado a la manifestación de no depender de la figura masculina para alcanzar la felicidad, hacen de The Diary of a Teenage Girl la máxima expresión de esta nueva poslolita. Palabras clave: Feminismo, cine, indie, Lolita, Nabokov. Abstract. La Belle Personne (Christophe Honoré, 2008), Fish Tank (Andrea Arnold, 2009) and The Diary of a Teenager (Marielle Heller, 2015), up to its germ: Lolita (1955), a novel written by Vladimir Nabokov and adapted to the great screen by Stanley Kubrick in 1962. From this connection, I analyze the final aspects of this new postlolita, framing the character in a concrete narrative journey and a conscious feminist discourse. The trip consists of three key moments: a first contact, the sexual encounter and the liberation from the situation of oppression. As for the feminist discourse, it reviews the figure of the postlitas as an object of desire, in addition to the relationship with the adult and the sexual initiation of young people. These three movies suppose the reinterpretation of the myth that Kubrick creates in his film. Also, this new reading of lolistism refers to the feminine appropriation of a discourse that has been exploited almost exclusively by men. This, added to the manifestation of not depending on the male figure to achieve happiness make The Diary of a teenager the ultimate expression of this new postlolita. Keywords: Feminism, film, indie, Lolita, Nabokov.
Una lección para todas: aciertos y errores de tres mujeres en compaña
Authors: Ibarra Villaescusa Tania M. 
Published: August 2018

Este artículo reseña: D’Artigues Katia, Una Lección para Todas: Aciertos y errores de tres mujeres en campaña”, Penguin Random House Grupo Editorial S.A. , 2015.
The Case for Comanagement and Care Pathways for Osteoporotic Patients with a Hip Fracture
Authors: Swart Eric , Kates Stephen , McGee Sarah , Ayers David C. 
Published: August 2018

* Rapid preoperative evaluation and clearance is an essential component of hip fracture care. Evidence-based guidelines should be used to reduce unnecessary testing and minimize delays.* Current practice guidelines recommend surgery within 24 to 48 hours of presentation, and a well-designed pathway can typically facilitate rapid surgery for all but the most medically unstable patients.* Institutionalized initiation of osteoporosis management in patients with a hip fracture improves patient outcomes and is cost-effective but must overcome multiple barriers. Several pragmatic programs have been developed to help orthopaedic surgeons facilitate this process.* Comanagement services need substantial work to establish, require teamwork among multiple engaged teams, and should create a culture of continuous process improvement.* When implemented successfully, comanagement services with dedicated care pathways can improve outcomes, reduce complications, streamline care, and result in cost savings.
Consejo Breve y Atención Plena para dejar de fumar: un estudio de caso
Authors: Almaraz Castruita Diana Aracely , Alonso Castillo María Magdalena 
Published: August 2018

Se presenta un caso clínico de un hombre de 51 años con dependencia al tabaco con una media de 52 cigarros fumados diariamente. Objetivo terapéutico: abandono del uso de tabaco, mediante estrategias que reduzcan el síndrome de abstinencia, el estrés y ansiedad. Método: Se aplicó un programa de 10 sesiones compuesto por Atención Plena y Consejería Breve. Para la redacción de este caso clínico se han seguido las normas de Buela-Casal y Sierra. Resultados: Al finalizar el tratamiento y durante el seguimiento el paciente se mantuvo abstinente, comprobado mediante un marcador biológico de cotinina en orina, así como una clara mejoría en los síntomas de ansiedad y estrés.
Structure-Based Docking Studies of GLUT4 Towards Exploring Selected Phytochemicals from Solanum xanthocarpum as a Therapeutic Target for the Treatment of Cancer
Authors: Oyinloye Babatunji Emmanuel , Adekiya Tayo Alex , Aruleba Raphael Taiwo , Ojo Oluwafemi Adeleke , Ajiboye Basiru Olaitan 
Published: August 2018

Background:In recent years, there has been an exponential increase in the global burden of cancer which has been associated with several factors including environmental influence, aging, diet, infectious agents, hormonal imbalance and chronic inflammation, among others. Cancerous cells utilize more glucose for its proliferation and survival than normal cells. Thus, the regulation of glucose consumption of cancerous cells through the inhibition of glucose transporter-4-protein (GLUT4) encoded by solute carrier family-2-member-4-gene (Slc2a4) by selected phytochemicals from Solanum xanthocarpum may serve as a new therapeutic candidate for the treatment of cancer.Methods:The seven identified potential inhibitors of GLUT4 from Solanum xanthocarpum were retrieved from PubChem database. Examination of their drug-likeness, toxicity prediction and molecular docking studies of these compounds with GLUT4 were carried out using online tools such as Molinspiration, PreADMET V.2.0 and Patchdock server.Results:The findings revealed that, five out of the seven compounds fulfil oral drugability of Lipinski’s rule of five (RO5) while two slightly meet the criteria of RO5. Conversely, five of the compounds are predicted to be mutagen while the remaining two are predicted to be safe for the body. Additionally, stigmasterol glucoside has higher binding-affinity (7590) with GLUT4 when compared to doxorubicin (6600) the control.Conclusion:These findings suggest that stigmasterol glucoside from Solanum xanthocarpum could be a promising therapeutic agent with better therapeutic efficacy than doxorubicin in the treatment of cancer via the inhibition of GLUT4.
Design, Synthesis and Evaluation of Thiourea Derivatives as Antimicrobial and Antiviral Agents
Authors: Ravichandran Veerasamy , Shalini Sivadasan , Kumar Krishnan Suresh , Rajak Harish , Agrawal Ram Kishore 
Published: August 2018

Background:
The development of drug-resistant by bacteria appears rapidly and thus making
the effectiveness of antibiotics severely limited.

Methods:
A series of thiourea derivatives was synthesized, characterized and evaluated for their in vitro
antibacterial, antifungal and antiviral activities.

Results:
Structures of the newly synthesized compounds were confirmed by elemental and spectral
analysis. The biological results showed that some of the target compounds displayed comparable antimicrobial
and antiviral activities with reference drugs. Structure-activity relationship studies revealed that
the ortho- chloro or fluoro substituted phenyl at Ar1 and substituted pyridinyl at Ar2 positions of the
thiourea nucleus are essential for their in vitro antimicrobial and anti-HIV activity. In particular, compounds
8 and 10 showed better activity against the tested bacteria, fungi and viral strains than other
synthesized PET derivatives reported in the present study.

Conclusion:
These results provide an encouraging lead that could be used for the development of new
potent antiviral and antimicrobial agents
Parental Burden and its Correlates in Families of Children with Autism Spectrum Disorder: A Multicentre Study with Two Comparison Groups
Authors: Picardi Angelo , Gigantesco Antonella , Tarolla Emanuele , Stoppioni Vera , Cerbo Renato , Cremonte Maurizio , Alessandri Guido , Lega Ilaria , Nardocci Franco 
Published: August 2018

Background:The effects of having a child with Autism Spectrum Disorder (ASD) on parents are multifaceted and pervasive. While ample evidence has been provided that these families are under severe stress, there are still several knowledge gaps and unresolved questions.Objective:This study aimed at quantifying the subjective and objective burden of ASD in mothers and fathers, and at improving the understanding of the interplay between parental burden, child’s characteristics, and parents’ coping resources and strategies.Methods:The parents of 359 children/adolescents with ASD were compared to parents of age-matched patients with Down syndrome (N=145) and Type 1 diabetes mellitus (N=155). Child’s clinical characteristics and parents’ caregiving burden, psychological distress, coping resources and strategies were assessed.Results:The parents of children with ASD reported higher objective and subjective burden, more frequent psychological distress, lower social support. Mothers reported greater subjective burden than fathers. Structural equation modeling showed that the most consistent positive and negative predictors of objective and subjective burden were ASD symptom severity and social support, respectively. Other positive predictors were engagement, distraction and disengagement coping, intellectual disability, and adaptive functioning. Other negative predictors were spiritual wellbeing and hardiness. Some effects were indirect through social support and coping strategies.Conclusion:This study confirmed that parents of children with ASD carry a huge caregiving burden, and added to our understanding of the factors associated with burden. The findings may help inform the design of effective interventions aimed at reducing burden among the parents of children with ASD.