bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remote supervision of rehabilitation interventions for survivors of moderate or severe traumatic brain injury: A scoping review
Authors: O’Neil Jennifer , van Ierssel Jacquie , Sveistrup Heidi 
Published: May 2019

Introduction Individuals with moderate or severe traumatic brain injury (TBI) often have persistent impairments upon discharge home. In rural communities, specialized rehabilitation services to address impairments can be difficult to access. The purpose of this scoping review is to examine how remote supervision is currently being used in TBI rehabilitation to identify gaps in knowledge that need to be addressed to facilitate access to and implementation of these services. Methods The main objective for this review is to identify the methods being used to deliver remote supervision for rehabilitation in a moderate or severe TBI population. The aim of this review was to document the implementation characteristics of remote supervision used including: (1) type of supervision such as synchronous, asynchronous supervision or mixed; (2) frequency and intensity of remote supervision; and (3) outcomes used to measure intervention delivery as well as effectiveness within this population. This scoping review follows EQUATOR Network recommendations for screening and extracting data. Results Twenty-six studies using a variety of remote supervision technology and outcome measures were included. Supervision frequency and intensity are poorly reported with no standardization. One hundred and six outcome measures were reported in this review showing large diversity in the areas being explored. Discussion Different types of remote supervision have been used with this population; however, there are no clear guidelines on clinical implementation. Future studies must better define implementation parameters of remote supervision. Benefit on physical activity, balance and mobility outcomes also need to be further explored.
Validated Prospective Assessment of Quality of Life After Robot-Assisted Laparoscopic Prostatectomy: Beyond Continence and Erections
Authors: Albisinni Simone , Aoun Fouad , Quackels Thierry , Assenmacher Grégoire , Peltier Alexandre , van Velthoven Roland , Roumeguère Thierry 
Published: May 2019

Continence and erectile function represent major concerns after robot-assisted laparoscopic prostatectomy (RALP), although the analysis of only these results may underestimate the impact of surgery on quality of life (QoL). The aim of the study is to prospectively analyze QoL after RALP according to the validated European Organization for Research and Treatment of Cancer Quality of Life Questionnaire prostate cancer–specific module (EORTC-QLQ-PR25) and C30 and explore risk factors for the deterioration of QoL after surgery. A total of 584 patients undergoing RALP were prospectively enrolled. QoL was assessed with the validated EORTC-QLQ-PR25 and C30. Differences across QoL items were assessed via Wilcoxon rank-sum test and associations between risk factors and QoL scores were tested via univariate and multivariate linear regression analyses. All items of the PR25 questionnaire showed a significant deterioration at 1 month after RALP and began to normalize 3 months after surgery. At 24 months follow-up, urinary, bowel, and sexual activity scores were not significantly different from preoperative scores, while incontinence aid, treatment-related symptoms, and sexual functioning remained significantly worse. Preoperative sexual activity was more important in determining 3-month sexual outcomes than preoperative 5-item version of the International Index of Erectile Function (IIEF-5) or nerve-sparing approach. An overall return to preoperative QoL was registered at 3 months after RALP in global and physical QoL, and most important, global, physical, social, and role-functioning QoL scores were improved at 12 and 24 months compared to preoperative scores. In this prospective study, detailed data on QoL are reported via the EORTC-PR25 and C30 questionnaires. While urinary, bowel, and sexual activity scores return to baseline values 24 months after surgery, incontinence aid, treatment-related symptoms, and sexual functioning may remain significantly deteriorated. Larger studies are needed to validate these findings.
Palliative Care in the Hip Fracture Patient
Authors: Sullivan Nicole M. , Blake Lindsay E. , George Masil , Mears Simon C. 
Published: May 2019

Introduction: Older patients with hip fracture have a 20% to 30% mortality rate in the year after surgery. Nonoperative care has higher 1-year mortality rates and is generally only pursued in those with an extraordinarily high surgical risk. As the population ages, more patients with hip fracture may fall into this category. The orthopedic surgeon is typically the main consultant responsible for deciding between surgery and conservative management, and the reasoning behind one decision over the other is often poorly understood. We undertook a review to determine decision-making tools for surgery in high-risk patients with hip fracture. Materials and Methods: A review was conducted using PubMed to determine articles published using the terms palliative care, conservative care, nonoperative, hip fracture, orthopedic procedures, fracture fixation, and surgery. Our search resulted in 13 articles to review. These were further screened to determine tools for use in surgical decision-making. Results: Several potential decision-making tools were found in our search. The potential tools to identify patients who would benefit from nonoperative treatment included the Palliative Performance Scale for severe dementia, the Lawton Instrumental Activities of Daily Living and Katz Activities of Daily Living scales for prefracture immobility, a combination of clinical signs and laboratory tests to determine risk of imminent death, and the Charlson Comorbidity Score for additional serious comorbidities. No tools have been prospectively tested in a clinical setting. Discussion: Evaluation of each patient using a variety of decision making tools should help the orthopedic surgeon determine which patients would be better suited to non-operative management. After determining the benefit of non-operative care, they must effectively allow the fracture to heal while ameliorating pain. Palliative care physicians can fulfill this role by providing support and symptom relief. Conclusions: Surgical decision-making for hip fracture repair in the elderly patients is not straight forward. Several tools may be helpful to the surgeon in determining who may be better suited for nonoperative care or a palliative care referral. Prospective data do not exist in these decision-making tools.
Epidemiology of Judo-Related Injuries in 21 Seasons of Competitions in France: A Prospective Study of Relevant Traumatic Injuries
Authors: Frey Alain , Lambert Christophe , Vesselle Benoit , Rousseau Romain , Dor Frédéric , Marquet Laurie Anne , Toussaint Jean François , Crema Michel Daoud 
Published: May 2019

Background: Judo is a full-contact fighting sport that may lead to severe injuries. There are limited data available on the incidence of judo-related injuries. The French Judo Federation has established a surveillance system to document the frequency and type of injuries during judo competitions. Purpose: To describe the incidence rates and types of judo-related traumatic injuries during 21 seasons of competitions in France with respect to athlete (judoka) age, sex, and level of performance. Study Design: Descriptive epidemiology study. Methods: Between 1993 and 2014, each physician in charge of each judo competition filled out a form in which he/she documented the number of competing judokas, the number of fights, the number of medical interventions, the specific type of traumatic injuries for each intervention, the number of fight interruptions, and the number of athletes removed from the competition venue because of an injury. The age, sex, and level of performance of each judoka were also documented. Variance analysis was applied to assess whether differences in incidence rates of injuries between groups were significant (Student t test and chi-square test). Results: Surveillance of 421,670 fights demonstrated 3511 injuries in 316,203 judokas (incidence proportion, 1.1%). Among the injuries recorded, the most common were sprains (54.3%), fractures (15.6%), and dislocations (12.5%). Female athletes exhibited significantly higher incidence rates for knee sprains and elbow dislocations, whereas male athletes exhibited a higher incidence rate for shoulder dislocations ( P < .001 for all). Regarding age, higher incidence rates were observed in young adults (aged 18-20 years) for acromioclavicular sprains and in children (aged 10-14 years) for clavicle fractures compared with adults (aged 21-35 years) ( P < .001 for both). Both young adult and adult athletes had a higher incidence rate of shoulder dislocations ( P < .001). Regarding the level of performance, athletes competing at higher levels had a higher incidence rate of sprains to the knee ( P < .001). Conclusion: During 21 years of surveillance of injuries in judo competitions in France, the incidence proportion of injuries was 1.1%. Significant differences in incidence rates demonstrated when considering age, sex, and level of performance may help in developing strategies to prevent traumatic injuries in the future.
Lussierite, a new sodium uranyl sulfate mineral with bidentate UO7–SO4linkage from the Blue Lizard mine, San Juan County, Utah, USA
Authors: Kampf Anthony R. , Olds Travis A. , Plášil Jakub , Nash Barbara P. , Marty Joe 
Published: June 2019

AbstractThe new mineral lussierite (IMA2018-101), Na10[(UO2)(SO4)4](SO4)2(H2O)3, was found in the Blue Lizard mine, San Juan County, Utah, USA, where it occurs as pale green–yellow prisms or blades in a secondary assemblage with belakovskiite, ferrinatrite, halite, ivsite, metavoltine and thénardite. The streak is white and the fluorescence is bright cyan under 365 nm ultraviolet light. Crystals are transparent with vitreous lustre. The tenacity is brittle, the Mohs hardness is 2½, the fracture is irregular and no cleavage was observed. The mineral is easily soluble in H2O and has a measured density of 2.87(2) g cm–3. Lussierite is optically biaxial (+), with α = 1.493(1), β = 1.505(1) and γ = 1.518(1) (white light); 2Vmeas.= 88(1)°; dispersion isr>v, moderate; pleochroism:X= colourless,YandZ= green yellow (X<Y≈Z); optical orientation:X=b,Z∧a= 44° in obtuse β. Electron microprobe analyses (wavelength-dispersive spectroscopy mode) provided Na10(U0.99O2)(S1.00O4)6·3H2O (+0.06 H for charge balance). The five strongest X-ray powder diffraction lines are [dobsÅ(I)(hkl)]: 6.69(95)($\bar{1}$11,130), 4.814(100)(150,002,060), 3.461(83)(171,$\bar{2}$02), 2.955(81)(113,330) and 2.882(74)($\bar{1}$91,311,191,0·10·0). Lussierite is monoclinic,Cc,a= 9.3134(4),b= 28.7501(11),c= 9.6346(7) Å, β = 93.442(7)°,V= 2575.1(2) Å3andZ= 4. The structure (R1= 0.0298 for 5202I> 2σI) contains a [(UO2)(SO4)4]6–uranyl sulfate cluster in which one SO4tetrahedron shares an edge (bidentate linkage) with the UO7pentagonal bipyramid. The uranyl sulfate clusters occur in layers and are linked through a complex network of bonds involving Na+cations, isolated SO4tetrahedra and isolated H2O groups.
Dysbiosis of the intestinal microbiota in neurocritically ill patients and the risk for death
Authors: Xu Ruoting , Tan Chuhong , Zhu Jiajia , Zeng Xiuli , Gao Xuxuan , Wu Qiheng , Chen Qiong , Wang Huidi , Zhou Hongwei , He Yan , Pan Suyue , Yin Jia 
Published: May 2019

Abstract
Background
Despite the essential functions of the intestinal microbiota in human physiology, little has been reported about the microbiome in neurocritically ill patients. This investigation aimed to evaluate the characteristics of the gut microbiome in neurocritically ill patients and its changes after admission. Furthermore, we investigated whether the characteristics of the gut microbiome at admission were a risk factor for death within 180 days.

Methods
This prospective observational cohort study included neurocritically ill patients admitted to the neurological intensive care unit of a large university-affiliated academic hospital in Guangzhou. Faecal samples were collected within 72 h after admission (before antibiotic treatment) and serially each week. Healthy volunteers were recruited from a community in Guangzhou. The gut microbiome was monitored via 16S rRNA gene sequence analysis, and the associations with the clinical outcome were evaluated by a Cox proportional hazards model.

Results
In total, 98 patients and 84 age- and sex-matched healthy subjects were included in the analysis. Compared with healthy subjects, the neurocritically ill patients exhibited significantly different compositions of intestinal microbiota. During hospitalization, the α-diversity and abundance of Ruminococcaceae and Lachnospiraceae decreased significantly over time in patients followed longitudinally. The abundance of Enterobacteriaceae was positively associated with the modified Rankin Scale at discharge. In the multivariate Cox regression analysis, Christensenellaceae and Erysipelotrichaceae were associated with an increased risk of death. The increases in intestinal Enterobacteriales and Enterobacteriaceae during the first week in the neurological intensive care unit were associated with increases of 92% in the risk of 180-day mortality after adjustments.

Conclusions
This analysis of the gut microbiome in 98 neurocritically ill patients indicates that the gut microbiota composition in these patients differs significantly from that in a healthy population and that the magnitude of this dysbiosis increases during hospitalization in a neurological intensive care unit. The gut microbiota characteristics seem to have an impact on patients’ 180-day mortality. Gut microbiota analysis could hopefully predict outcome in the future.
Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity
Authors: Brychta Robert J , Huang Shan , Wang Juan , Leitner Brooks P , Hattenbach Jacob D , Bell Sarah L , Fletcher Laura A , Perron Wood Rachel , Idelson Christopher R , Duckworth Courtney J , McGehee Suzanne , Courville Amber B , Bernstein Shanna B , Reitman Marc L , Cypess Aaron M , Chen Kong Y 
Published: May 2019

AbstractObjectiveCold exposure increases energy expenditure (EE) and could have a role in combating obesity. To understand this potential, we determined the capacity for cold-induced thermogenesis (CIT), the EE increase above the basal metabolic rate at the individualized coldest tolerable temperature before overt shivering.DesignDuring a 13-day inpatient protocol, we quantitated the EE of 12 lean men and 9 men with obesity at various randomly ordered ambient temperatures in a room calorimeter. Subjects underwent brown fat imaging after exposure to their coldest tolerable temperature.ResultsCIT capacity was 300 ± 218 kcal/d (mean ± SD) or 17 ± 11% in lean men and 125 ± 146 kcal/d or 6 ± 7% in men with obesity (P = 0.01). The temperature below which EE increased, lower critical temperature (Tlc), was warmer in lean men than men with obesity (22.9 ± 1.2 vs 21.1 ± 1.7°C, P = 0.03), but both had similar skin temperature (Tskin) changes and coldest tolerable temperatures. Whereas lean subjects had higher brown fat activity, skeletal muscle activity increased synchronously with CIT beginning at the Tlc in both groups, indicating that muscle is recruited for CIT in parallel with brown fat, not sequentially after nonshivering thermogenesis is maximal.ConclusionsDespite greater insulation from fat, men with obesity had a narrower range of tolerable cool temperatures available for increasing EE and less capacity for CIT than lean men, likely as a result of greater basal heat production and similar perception to Tskin cooling. Further study of the reduced CIT capacity in men with obesity may inform treatment opportunities for obesity.
Incorporating Clinical Practice Guidelines and Quality Measures Into High-Quality Cost-Effective Care for Patients With Multiple Sclerosis
Authors: Rae-Grant Alexander D. 
Published: June 2019

ABSTRACT
This article presents a hypothetical case of a patient with multiple sclerosis (MS), reviewing the use of clinical practice guidelines and incorporation of quality measures into practice. Appropriate diagnosis of MS is important to avoid the cost and consequences of a misdiagnosis. Ensuring that treatment discussion occurs when a patient with MS is receptive is good clinical practice and a guideline recommendation from the American Academy of Neurology. Continuing dialogue about disease-modifying therapy and ongoing monitoring are important for patient care and improved outcomes. Ultimately, cost-effective care in MS relates to using appropriate medicines in patients with active MS, ensuring adherence, and careful monitoring.
Poly(3,4-ethylenedioxythiophene) Grains Synthesized by Solvent-free Chemical Oxidative Polymerization
Authors: Inoue Hiroki , Shimogama Natsuko , Seike Musashi , Oyama Keigo , Mukai Shun , Higashimoto Shinya , Hirai Tomoyasu , Nakamura Yoshinobu , Fujii Syuji 
Published: June 2019

Abstract
Poly(3,4-ethylenedioxythiophene) (PEDOT) grains were synthesized by solvent-free chemical oxidative polymerization in one-step and one-pot manner. The resulting PEDOT grains had atypical shapes with a volume-average diameter of 57 ± 45 µm and showed an electrical conductivity of 1.9 × 10−3 S cm−1. Furthermore, it was clarified that the PEDOT grains showed light-to-heat photothermal property.
Postpartum family planning in Rwanda: a cost effectiveness analysis
Authors: Williams Pamela , Morales Katie , Sridharan Vikram , Tummala Alekya , Marseille Elliot 
Published: June 2019

Background: Globally, there is a large unmet need for family planning in the postpartum period: 90% of women in this group want family planning for birth spacing or to avoid unintended pregnancies and stop child bearing once desired family size has been reached. Women spend on average about 30 years, or three-quarters of their reproductive lives, attempting to avoid pregnancy. In total 76% of Rwandan women want family planning postpartum, yet a 26% unmet need remains. Methods: This cost effectiveness analysis compared the two most frequently-used family planning methods in Rwanda, longer-acting reversible contraception (LARC), injections and subdermal implants, and shorter-acting reversible contraceptives (non-LARC), pills and condoms. Women who do not use contraception postpartum were also represented. A time horizon of 24 months was used to reflect the World Health Organization suggested two-year spacing from birth until the next pregnancy, and the analysis was conducted from a health systems perspective. Results: For women of reproductive age (15-49 years) in Rwanda, including LARC postpartum family planning methods in the options, saves $18.73 per pregnancy averted, compared to family planning options that offer non-LARC methods exclusively. Conclusion: There is an opportunity to avert unplanned pregnancies associated with the increased utilization of LARC methods. Despite the availability of LARC methods in many of Rwanda’s health facilities, the full benefits are not yet realized. LARC is cost-saving compared with non-LARC methods. Effective public health messaging campaigns and other promotion targeting current resistance to LARC use for the postpartum population could both enhance health and save public health funds.
Good sex matters: Pleasure as a driver of online sex education for young people
Authors: van Clief Lindsay , Anemaat Elianne 
Published: June 2019

Background There are few documented examples of online sex education platforms that make an impact on young people’s sexual health and wellbeing, yet research shows that new media has enormous potential to be harnessed in this way. The same is true for a pleasure-positive approach to sex education curricula and programmes. This research provides empirical evidence from the Love Matters' websites in Mexico, Kenya, Nigeria, Egypt, and India to highlight the prevalence and importance of talking about pleasure-related topics with young people. Methodology Love Matters is an online sex education platform targeting seven countries and attracting 30 million website visits in 2018. We analysed data through Google Analytics to explore the difference between sex education-focused content and pleasure-focused content and how young people engage with different types of sexual health information on the Love Matters platforms. Results Pleasure-focused content is 1.5 times more popular than sex education-focused content across all platforms. However, education-focused content attracts more organic traffic, suggesting young people purposefully search for sexual health information online. Users generally spend longer on the site engaging with sex education-focused content than pleasure-focused content. Conclusion This research provides empirical evidence from five countries in the Global South to support the notion that young people are actively looking for sexual health information that covers the full scope of sexual experience and pleasure, including – but not limited to – the reduction of health risks. This paper furthers the efforts to adopt a pleasure-positive approach to both online and offline sex education interventions.
Characterization of bone ingrowth and interface mechanics of a new porous 3D printed biomaterial
Authors: Tanzer M. , Chuang P. J. , Ngo C. G. , Song L. , TenHuisen K. S. 
Published: May 2019

Aims The purpose of this study was to evaluate the biological fixation of a 3D printed porous implant, with and without different hydroxyapatite (HA) coatings, in a canine model. Materials and Methods A canine transcortical model was used to evaluate the characteristics of bone ingrowth of Ti6Al4V cylindrical implants fabricated using laser rapid manufacturing (LRM). At four and 12 weeks post-implantation, we performed histological analysis and mechanical push-out testing on three groups of implants: a HA-free control (LRM), LRM with precipitated HA (LRM-PA), and LRM with plasma-sprayed HA (LRM-PSHA). Results Substantial bone ingrowth was observed in all LRM implants, with and without HA, at both time periods. Bone ingrowth increased from 42% to 52% at four weeks, to 60% to 65% at 12 weeks. Mechanical tests indicated a minimum shear fixation strength of 20 MPa to 24 MPa at four weeks, and 34 MPa to 40 MPa at 12 weeks. There was no significant difference in the amount of bone ingrowth or in the shear strength between the three implant types at either time period. Conclusion At four and 12 weeks, the 3D printed porous implants exhibited consistent bone ingrowth and high mechanical shear strength. Based on the results of this study, we confirmed the suitability of this novel new additive manufacturing porous material for biological fixation by bone ingrowth. Cite this article: Bone Joint J 2019;101-B(6 Supple B):62–67.
Will registries slow down or accelerate innovation?
Authors: Carr Andrew 
Published: June 2019

The increasing use of regional and national registries of surgical implants has raised concerns that the cost and consequences of these initiatives will adversely influence innovation. The opposite appears to be true, with no evidence of a reduction in overall innovation and an association of increased innovation in countries with more evaluation using registries. Cite this article: EFORT Open Rev 2019;4 DOI: 10.1302/2058-5241.4.180065