bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hearing impairment after subarachnoid hemorrhage
Authors: Campbell Nicci , Verschuur Carl , Mitchell Sophie , McCaffrey Orlaith , Deane Lewis , Taylor Hannah , Smith Rory , Foulkes Lesley , Glazier James , Darekar Angela , Haacke Mark E. , Bulters Diederik , Galea Ian 
Published: January 2019

AbstractBackgroundSubarachnoid hemorrhage (SAH) survivors experience significant neurological disability, some of which is under‐recognized by neurovascular clinical teams. We set out to objectively determine the occurrence of hearing impairment after SAH, characterize its peripheral and/or central origin, and investigate likely pathological correlates.MethodsIn a case‐control study (n = 41), participants were asked about new onset hearing difficulty 3 months post‐SAH, compared with pre‐SAH. Formal audiological assessment included otoscopy, pure tone audiometry, a questionnaire identifying symptoms of peripheral hearing loss and/or auditory processing disorder, and a test of speech understanding in noise. A separate cohort (n = 21) underwent quantitative susceptibility mapping (QSM) of the auditory cortex 6 months after SAH, for correlation with hearing difficulty.ResultsTwenty three percent of SAH patients reported hearing difficulty that was new in onset post‐SAH. SAH patients had poorer pure tone thresholds compared to controls. The proportion of patients with peripheral hearing loss as defined by the World Health Organization and British Audiological Society was however not increased, compared to controls. All SAH patients experienced symptoms of auditory processing disorder post‐SAH, with speech‐in‐noise test scores significantly worse versus controls. Iron deposition in the auditory cortex was higher in patients reporting hearing difficulty versus those who did not.ConclusionThis study firmly establishes hearing impairment as a frequent clinical feature after SAH. It primarily consists of an auditory processing disorder, mechanistically linked to iron deposition in the auditory cortex. Neurovascular teams should inquire about hearing, and refer SAH patients for audiological assessment and management.
Improving Cancer Vaccine Efficiency by Nanomedicine
Authors: Cai Junyu , Wang Hao , Wang Dangge , Li Yaping 
Published: January 2019

AbstractCancer vaccines, which have been widely investigated in the past few decades, are one of the most attractive strategies for cancer immunotherapy. Through the precise delivery of antigens and adjuvants to lymphoid organs or lymphocytes via nanotechnology, innate and adaptive immunity can be boosted to prevent the growth and relapse of malignant tumors. Indeed, nanomedicine offers great opportunities to improve the efficiency of vaccines. Various functional platforms are used to deliver small molecules, peptides, nucleic acids, and even whole cell antigens to the target area of interest, achieving enhanced antitumor immunity and durable therapeutic benefits. Herein, the recent progress in cancer vaccines based on nanotechnology is summarized. Novel platforms used for delivering tumor antigens, promoting adjuvant functions, and combining other therapeutic strategies are discussed. Moreover, possible striving directions and major challenges of nanomedicine for vaccination are also reviewed.
MAPK‐Targeted Drug Delivered by a pH‐Sensitive MSNP Nanocarrier Synergizes with PD‐1 Blockade in Melanoma without T‐Cell Suppression
Authors: Liu Xiaowei , Feng Yanlin , Xu Guangchao , Chen Yang , Luo Ya , Song Jinen , Bao Yu , Yang Jiqiao , Yu Chune , Li Yanna , Ye Haoyu , Ke Bowen , Chen Bo , Hu Jianping , Xu Jie , Meng Huan , Zhang Haiyuan , Shi Hubing 
Published: January 2019

AbstractThe combination of BRAF/MEK‐targeted therapy with immune checkpoint blockade is regarded as a promising regimen for patients with metastatic melanoma due to their complementary advantages. However, MEK‐inhibitor‐induced T‐cell toxicity impedes effective cooperation. In this experiment, a pH‐responsive on‐demand controlled release mesoporous silica nanoparticles (MSNPs) system is designed. Fluorescein‐isothiocyanate‐loaded MSNP can be specifically delivered into tumor cells rather than T‐cells. MEK‐inhibitor‐loaded MSNP avoids proliferative and functional inhibitions of T‐cells, while preserving growth suppression of tumor cells in vitro. In an in vivo model, MSNP encapsulation reverses the MEK‐inhibitor‐induced suppression of activated CD8+ T‐cells, and enhances the secretion of INF‐γ and IL‐2. The combination of BRAF inhibitor plus MSNP‐loaded MEK inhibitor and anti‐PD‐1 antibody synergistically inhibits tumor growth via promoting robust immune‐related antitumor response. This work provides a novel and generalized framework for combining T‐cell‐impaired targeted therapy and immune checkpoint blockade by using a nanoparticle‐based delivery system.
Bowtie‐Shaped NiCo2O4 Catalysts for Low‐Temperature Methane Combustion
Authors: Dai Yiling , Kumar Vanama Pavan , Zhu Chujie , Wang Haiyan , Smith Kevin J. , Wolf Michael O. , MacLachlan Mark J. 
Published: January 2019

AbstractBowtie‐shaped NiCo2O4 nanostructures are prepared using a hydrothermal method. Variation of the synthesis parameters, including reaction time, additives, and calcination temperature, allows an understanding of the origin of the bowtie‐shaped structure to be developed. Methane oxidation experiments performed using temperature‐programed oxidation (TPO) show that the new materials, which do not contain precious metals, have excellent activity for low‐temperature methane combustion, with 100% conversion at ≈410 °C (gas hourly space velocity (GHSV): 90 000 mL (STP) g−1 h−1). The structure–activity relationships of the bowtie‐shaped nanostructures are explored.
Polarized THz Emission from In‐Plane Dipoles in Monolayer Tungsten Disulfide by Linear and Circular Optical Rectification
Authors: Zhang Longhui , Huang Yuanyuan , Zhu Lipeng , Yao Zehan , Zhao Qiyi , Du Wanyi , He Yuhang , Xu Xinlong 
Published: January 2019

AbstractRecent advances in the development of polarized terahertz (THz) emission from nanomaterials have not only opened up a new “TeraNano” interdiscipline but also provided a new tool for nonlinear optical process research. Herein, THz radiation mechanism of monolayer tungsten disulfide (WS2) is first investigated by both linear and circular polarization laser excitations at room temperature. The results reveal that polarized THz emission is dominated by the optical rectification based on in‐plane nonlinear dipoles, which is totally different from that of bulk WS2. The mechanism is verified by the azimuthal angle and pump polarization angle dependence of THz emission in both experiment and theory. Furthermore, controllably elliptically polarized THz emission is observed with the maximum ellipticity of ≈0.52 based on nonresonant nonlinear process under the circularly polarized excitation. A clear understanding of THz radiation mechanism of 2D materials will facilitate further design, optimization, and polarization control of integrable 2D THz optoelectronics.
Formation of papillary mucosa folds and enhancement of epithelial barrier in odontogenic sinusitis
Authors: Zhang Yuan , Lan Feng , Li Ying , Wang Chengshuo , Zhang Luo 
Published: January 2019

BackgroundOdontogenic sinusitis (OS) presents more satisfactory therapeutic effect after endoscopic surgery compared with chronic rhinosinusitis (CRS) of other origin. The aim of the present study was to investigate the clinical characteristics, morphological features, and epithelial barrier function of sinus mucosa of OS and discuss the possible relationship with good prognosis.MethodsA total of 25 subjects with OS, 7 CRS without nasal polyps (CRSsNP), 10 CRS with nasal polyps (CRSwNP), and 9 control subjects were recruited. The biopsy specimens were stained with hematoxylin and eosin for general observation of cytomorphologic features. Epithelial tight junctions (TJs) protein claudin‐4 expression was determined to evaluate the epithelial barrier integrity by using immunofluorescence and Image‐Pro Plus software analysis. The representative cytokine profiles regarding T helper 1 (Th1) (interferon [IFN]‐γ), Th2 (interleukin [IL]‐5), and Th17 (IL‐17) were examined by reverse transcription–polymerase chain reaction (RT‐PCR).ResultsExtensively small papillary protrusions could be seen in the maxillary sinus mucosa of OS patients under nasal endoscopy, similar to the morphological behavior, which also presented as papillary folds in the surface of the epithelium. The epithelium in OS kept an increased claudin‐4 expression compared with that seen in CRSsNP, CRSwNP, and control subjects. The inflammatory pattern analysis demonstrated that OS belonged to the lymphocyte and plasma cell‐dominant cellular phenotypes, whereas IL‐17 was dominant compared with IFN‐γ as well as IL‐5.ConclusionThe odontogenic infections might induce the formation of papillary mucosa folds and enhance the epithelial TJ barrier function. OS exhibited as lymphocyte and plasma cell–dominant cellular phenotypes and Th17 cytokine profiles.
The formation of fibrous structure of polyamide 6 induced by the three‐step forming process and its prominent reinforcement in nitrile rubber
Authors: Cai Ziqing , Jia Zhenyu , Wang Tao 
Published: January 2019

ABSTRACTNitrile rubber (NBR) blends with excellent performance have always been a hot research topic in petroleum field. Due to the excellent performance and compatibility of polyamide 6 (PA6), it provides an opportunity for the preparation of high‐performance NBR/PA6 blends. In this article, NBR/PA6 blends were prepared by the three‐step molding process. Experimentally, it was found that PA6 has a prominent reinforcement effect in NBR matrix. The variation of this mechanical property was investigated from different aspects of the crystal structure, crystallinities, phase morphology, and so on. It can be cleared that the formation of fibrous structure of PA6 phase is the main factor for reinforcement of the polymer blends. Meanwhile, the formation mechanism of the special phase structure induced by the three‐step process is deeply expounded and its structural evolution schematic is established. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47472.
A high‐throughput method of analyzing multiple plant defensive compounds in minimized sample mass
Authors: Jack Chandra N. , Rowe Shawna L. , Porter Stephanie S. , Friesen Maren L. 
Published: January 2019

Premise of the StudyCurrent methods for quantifying herbivore‐induced alterations in plant biochemistry are often unusable by researchers due to practical constraints. We present a cost‐effective, high‐throughput protocol to quantify multiple biochemical responses from small plant tissue samples using spectrophotometric techniques.Methods and ResultsUsing Solanum lycopersicum and Medicago polymorpha leaves pre‐ and post‐herbivory, we demonstrate that our protocol quantifies common plant defense responses: peroxidase production, polyphenol oxidase production, reactive oxygen species production, total protein production, and trypsin‐like protease inhibition activity.ConclusionsCurrent protocols can require 500 mg of tissue, but our assays detect activity in less than 10 mg. Our protocol takes two people 6 h to run any of the assays on 300 samples in triplicate, or all of the assays on 20 samples. Our protocol enables researchers to plan complex experiments that compare local versus systemic plant responses, quantify environmental and genetic variation, and measure population‐level variation.
The role of alexithymia in parent–child interaction and in the emotional ability of children with autism spectrum disorder
Authors: Costa Andreia P. , Steffgen Georges , Vögele Claus 
Published: January 2019

Children with autism spectrum disorder (ASD) have more emotional difficulties than typically developing (TD) children. Of all the factors that impact children's emotional development, parents, and the way they interact with their children, are of crucial importance. The present study compared the amount of parent–child interactions among 35 dyads of parents and their children with ASD and 41 dyads of parents and their TD children, aged between 3 and 13 years, during a frustration‐eliciting situation. We further examined whether children's alexithymia is linked to parent–child interactions and whether parent–child interactions are linked to children's emotional difficulties. We found that parents of children with ASD interacted significantly less with their children than parents of TD children. This reduced interaction was better explained by children's alexithymia than by children's ASD diagnosis. Finally, parent–child interaction mediated the relationship between children's ASD diagnosis and children's emotion regulation ability, as well as some aspects of children's emotional reactivity but only if not accounting for children's alexithymia levels. Our results demonstrate the determinant role children's alexithymia plays on parent–child interactions and on how these interactions are linked to children's difficulties in emotion regulation and emotional reactivity. Results are discussed in light of how parent–child interactions and the emotional ability of children with ASD can be improved by targeting children's alexithymia. Autism Res 2019, 12: 458–468 © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryIn the present research, we found that parents of children with autism interact less with their children compared to parents of typically developing children. We also found that this decreased interaction is linked to children's difficulties to recognize, describe, and distinguish emotions, a triad of difficulties known as alexithymia. Furthermore, parents' interaction with their children explains emotional reactivity and emotion regulation problems in children with autism. However, if we take into consideration children's alexithymia, then parents' interaction with their children is not related to their children's emotional difficulties in reactivity and regulation. Therefore, to improve the interaction between parents and their children with autism, and the emotional development of these children, we recommend interventions that teach children with autism how to recognize, describe, and distinguish emotions in themselves and others.
Disseminating technology in global surgery
Authors: Bolton W S , Aruparayil N , Quyn A , Scott J , Wood A , Bundu I , Gnanaraj J , Brown J M , Jayne D G 
Published: January 2019

Abstract

Background
Effective dissemination of technology in global surgery is vital to realize universal health coverage by 2030. Challenges include a lack of human resource, infrastructure and finance. Understanding these challenges, and exploring opportunities and solutions to overcome them, are essential to improve global surgical care.

Methods
This review focuses on technologies and medical devices aimed at improving surgical care and training in low- and middle-income countries. The key considerations in the development of new technologies are described, along with strategies for evaluation and wider dissemination. Notable examples of where the dissemination of a new surgical technology has achieved impact are included.

Results
Employing the principles of frugal and responsible innovation, and aligning evaluation and development to high scientific standards help overcome some of the challenges in disseminating technology in global surgery. Exemplars of effective dissemination include low-cost laparoscopes, gasless laparoscopic techniques and innovative training programmes for laparoscopic surgery; low-cost and versatile external fixation devices for fractures; the LifeBox pulse oximeter project; and the use of immersive technologies in simulation, training and surgical care delivery.

Conclusion
Core strategies to facilitate technology dissemination in global surgery include leveraging international funding, interdisciplinary collaboration involving all key stakeholders, and frugal scientific design, development and evaluation.
Global surgery and the sustainable development goals
Authors: Roa L , Jumbam D T , Makasa E , Meara J G 
Published: January 2019

AbstractBackgroundThe field of global surgery has gained significant recent momentum, catalysed by the 2015 publication of the Lancet Commission on Global Surgery, Disease Control Priorities 3 and World Health Assembly resolution 68.15. These reports characterized the global burden of disease amenable to surgical care, called for global investment in surgical systems, and recognized surgery and anaesthesia as essential components of universal health coverage.MethodsA strategy proposed to strengthen surgical care is the development of national surgical, obstetric and anaesthesia plans (NSOAPs). This review examined how NSOAPs could contribute to the achievement of sustainable development goals (SDGs) 1, 3, 5, 8, 9, 10, 16 and 17 by 2030, focusing on their potential impact on the healthcare systems in Ethiopia, Tanzania and Zambia.ResultsDue to the cross-cutting nature of surgery, obstetrics and anaesthesia, investing in these services will escalate progress to achieve gender equality, economic growth and infrastructure development. Universal health coverage will not be achieved without addressing the financial ramifications to the poor of seeking and receiving surgical care. NSOAPs provide a strategic framework and a data collection platform for evidence-based policy-making, accountability and implementation guidance.ConclusionThe development and implementation of data-driven NSOAPs should be recognized as a powerful road map to accelerate achievement of the SDGs by 2030.
Growing research in global surgery with an eye towards equity
Authors: Hedt-Gauthier B L , Riviello R , Nkurunziza T , Kateera F 
Published: January 2019

AbstractBackgroundGlobal surgery research is often generated through collaborative partnerships between researchers from both low- and middle-income countries (LMICs) and high-income countries (HICs). Inequitable engagement of LMIC collaborators can limit the impact of the research.MethodsThis article describes evidence of inequities in the conduct of global surgery research and outlines reasons why the inequities in this research field may be more acute than in other global health research disciplines. The paper goes on to describe activities for building a collaborative research portfolio in rural Rwanda.ResultsInequities in global surgery research collaborations can be attributed to: a limited number and experience of researchers working in this field; time constraints on both HIC and LMIC global surgery researchers; and surgical journal policies. Approaches to build a robust, collaborative research portfolio in Rwanda include leading research trainings focused on global surgery projects, embedding surgical fellows in Rwanda to provide bidirectional research training and outlining all research products, ensuring that all who are engaged have opportunities to grow in capacities, including leading research, and that collaborators share opportunities equitably. Of the 22 published or planned papers, half are led by Rwandan researchers, and the research now has independent research funding.ConclusionIt is unacceptable to gather data from an LMIC without meaningful engagement in all aspects of the research and sharing opportunities with local collaborators. The strategies outlined here can help research teams build global surgery research portfolios that optimize the potential for equitable engagement.
The relationship between mindfulness, spiritual well‐being and chronic depression: Different predictors in distinct phases of treatment
Authors: Ramadas Eduardo , Simões Sónia Catarina 
Published: January 2019

AbstractObjectiveThis study sought to analyse the relationship between mindfulness, spiritual well‐being and chronic depression, together with the possible predictive power of the independent variables, during and after a therapeutic intervention. Clients were treated in a residential therapeutic unit for a period of 3–6 months.MethodThe research sample consisted of 63 patients, 28 females and 35 males, between 15 and 57 years old (M = 32.84, SD = 10.24), separated into two groups: residential phase (In‐Treatment) and after termination of treatment (Post‐Treatment). The In‐Treatment group included 32 participants halfway into treatment, and the Post‐Treatment group included 31 participants who had concluded the intervention at least 1 year previously. All the clients had been diagnosed with chronic depression disorder. The instruments used were as follows: the Beck Depression Inventory‐II, the Five facet mindfulness questionnaire and the spiritual well‐being questionnaire.ResultsMindfulness dimensions are more relevant during treatment, contrary to spiritual well‐being dimensions. There were significant negative associations between mindfulness and depression in the In‐Treatment group. In the Post‐Treatment group, there were significant negative associations between all the spiritual dimensions (barring the transcendental dimension) and depression. The non‐reactivity dimension of mindfulness was a significant predictor of depression in the In‐Treatment group, while the environmental dimension of spiritual well‐being was a significant predictor in the Post‐Treatment group.ConclusionThe results support the known associations between the studied variables, but indicate that in different phases of treatments, mindfulness and spiritual well‐being have a different impact.
Mnx(PO4)y/NPC As a High Performance Bifunctional Electrocatalyst for Oxygen Electrode Reactions
Authors: Wang Shuai , Nam Gyutae , Li Ping , Jang Haeseong , Wang Jia , Kim Min Gyu , Wu Zexing , Liu Xien , Cho Jaephil 
Published: January 2019

AbstractDeveloping highly efficient and durable bifunctional electrocatalyst for oxygen reduction (ORR) and oxygen evolution reaction (OER) is quite important for developing rechargeable zinc‐air batteries. Herein, one kind of manganese phosphate‐based electrocatalyst (Mnx(PO4)y/NPC) with high specific surface area (1106.9 m2 g−1) is prepared via a facile and scalable avenue, which possesses remarkable catalytic performance for the both ORR and OER, indicated by a more positive half‐wave potential of 0.87 V in 0.1 M KOH for the ORR as well as an overpotential of 0.37 V to achieve the current density of 10 mA cm−2 in 1 M KOH for the OER. Furthermore, the Mnx(PO4)y/NPC assembled rechargeable zinc‐air battery shows an excellent charge‐discharge cycling performance, revealed by the smaller sum of charge‐discharge potentials, comparable to that of Pt/C+IrO2. This research adds a new kind of electrocatalyst into the family of non‐noble metal‐based bifunctional electrocatalyst for rechargeable zinc‐air batteries.