bluuebunny/crossref_metadata_2025_split huggingface dataset:
Los Menores De Edad En El Pacto De Estado Contra La Violencia De Género
Authors: Presas Inmaculada García 
Published: July 2019

Desafortunadamente todavía persiste la violencia género y, por ello, los países europeos luchan, incansablemente, para erradicarla. En España, en 2017, se aprueba el Pacto de Estado contra la violencia de género que contiene medidas, algunas relacionadas con los menores. Entre ellas se encuentra la no imposición de la guarda y custodia compartida o la suspensión de visitas del padre maltratador, que, además, tiene prohibido acceder a grabaciones de exploración judicial de sus hijos.
Los distintos países creen conveniente endurecer el Derecho Penal de menores. En España no son imputables hasta los 14 años y, a partir de esta edad, se aplica la Ley orgánica 5/2000, de 12 de enero, reguladora de la responsabilidad penal de los menores, que impone medidas distintas a las previstas para los adultos y destinadas, fundamentalmente, a la reeducación y resocialización. Los menores, además de maltratadores, pueden ser víctimas de violencia de género, directamente o como testigos de la violencia ejercida por uno de sus progenitores hacia el otro.
En España el Pacto de Estado considera víctimas directas de violencia de género a las madres cuyas parejas o exparejas asesinan a sus hijos. El Pacto de Estado no solo se refiere a los menores asesinados ya que, también, hace alusión a los huérfanos, otorgándole acceso prioritario a las pensiones de orfandad y becas y, concediéndole, a quien ostenta su guarda y custodia, beneficios fiscales y prioridad en el acceso a viviendas de protección.
Correlation of Cholinesterase Levels to Lung Function in Farmer Exposed by Organophosphate Pesticides in Sukorambi Village, Jember Regency
Authors: Sandra Puput Sagita Mey , Sofiana Kristianingrum Dian , Sutejo Ika Rahmawati 
Published: July 2019

Abstract

Most of the Indonesia population work as a farmer. Pesticides are used in agriculture sector for pest and plant diseases. Pesticides can cause intoxication. The World Health Organization (WHO) estimates that 1-5 million cases of pesticides poisoning among agricultural workers occur in developing countries. Indonesia pesticide poisoning cases reach 771 cases. Organophosphate enter the body through inhalation. Organophosphate pesticides work systemic to inhibit the cholinesterase enzyme causing lung function disorders. The purpose of this study was to analyze the correlation of cholinesterase levels to lung function in farmers exposed to organophosphate pesticides in Sukorambi Village, Jember Regency. This is an observational analytic study using a cross sectional design. Cholinesterase levels test using the DGKC method to determine the presence of poisoning, while for lung function test using spirometry with FVC, FEV1 and FEV1 / FVC ratios as parameters. The results of the test in 30 samples showed 14.33% (4/30) abnormal cholinesterase levels or decreased. Lung function test showed 20% (6/30) had obstructive disorders, 43.33% (13/30) restrictive disorders and 36.67% (11/30) were normal. Data analysis using chi square showed a significant relationship (p = 0.049) between cholinesterase levels and lung function. Conclusion: There is a significant relationship between the level of cholinesterase to decrease in pulmonary physiology of farmers exposed to organophosphate pesticides in Sukorambi Village, Jember Regency.

Keyword :Organophosphate, cholinesterase level, lung function
The Usage of Data Mining Technology in Financial Information System
Authors: Uzar Ceren 
Published: July 2019

Data mining technology is one of the new technologies that have become increasingly popular. Data mining enables to form forecasts and models regarding future by making use of past data. It can be costly, risky and time consuming for enterprises to gain knowledge. Firms gain important competitive advantage by data mining methods. This study analyzes on the readiness to implement and the extent of utilization of data mining technologies in the Financial Information Systems (FIS) in Borsa Istanbul and also researches the level of understanding of, perceptions of and readiness to implement data mining technologies within the Borsa Istanbul. Analysis was undertaken using SPSS. Manufacturing and financial enterprises are the universal of this study. Primary data were obtained by using survey method and questionnaire technique and findings of the study were evaulated. Technological, organisational and human resources issues had a significant role in the decision to, or not to utilize data mining technology. The ability to use data mining technology was found to be increased the performance of the Financial Information System.
A Survey of the Perception of the Services of Micro Finance Institutions by the Female Service Users in Benin City, South-South, Nigeria
Authors: Ugiagbe Ernest Osas 
Published: July 2019

The study examines the perceptions of the services of the micro finance Institutions by the women service users, and how the services of micro Institutions affect businesses of the beneficiaries of the micro credit loans. The research design for the study was the survey method. The instruments of data collection were structured questionnaires and in-depth interview. A total of 450 questionnaires were administered to the female participants, and senior management personnel of the micro credit institutions were interviewed. The cluster and simple random sampling were used to select the participants for the study. The leaders of registered unions were the informants. The result reveals that the poor services and attitude of officials of micro finance institutions and other problems like the regressive tax regimes, harsh economic climate and patriarchy are negatively affecting the business ventures of the loan beneficiaries and by implication the goals of poverty reduction via micro credit scheme . The women beneficiaries are groaning under the burden of loan repayment and meeting other obligations as mothers and wives. This study is applicable in the context of social policy development at this time when social services delivery is not only poor but at dismal level. The need for gender sensitive and social development becomes imperative. It is critical to social work practice in the context of advocacy, empowerment programs, facilitating and initiating service delivery and Community organizing by social workers that will enhance the war against Poverty and other social impediments against women empowerment in Nigeria.
Accounting Treatment of Biological Assets for Agricultural Companies in Jember and Bondowoso
Authors: Widiyanti Novi Wulandari , Maharani Bunga , Purnamawati Indah 
Published: July 2019

Application of IAS 41-Agriculture in developed countries contrast with agricultural entities conditions in developing countries especially for Indonesia. The adoption of IAS 41 makes DSAK-IAI issue PSAK 69 Agriculture intended for agricultural entities so that they can measure and record related biological assets of a company. However, the application of PSAK 69 to agricultural companies also facing problems such as changes in accounting treatment especially for accounting method which are changed form historical value to fair value. The purpose of this study is to provide an overview of accounting treatment of biological asset in Jember plantation companies in state-owned plantation companies in Jember and Bondowoso regencies, namely PTPN 12 and PTPN 11 (PG Pradjekan). The methode used was descriptive qualitative. The researchs showed that differences in biological assets of each company can cause differences in the recording of biological assets. The differences between the two companies are in terms of plant type, plant age and costs incurred in each type of plant. However, in other cases, the accounting treatment of biological assets in PTPN 11 (PG Pradjekan) and PTPN 12 has similarity on recording biological assets at acquisition cost method. This study shows that currently both companies are still used accounting records with a historical value approach that accumulates all costs incurred from the nursery process until the plants are transformed into yielding crops.
Membangun Karakter Nasionalisme Melalui Pengembangan Bahan Ajar Ensiklopedia pada Materi Tokoh-tokoh Proklamasi
Authors: Sulistyowati Prihatin , Wahidiyah Dewi Masruroh Nur , Setiawan Dwi Agus 
Published: July 2019

Pentingnya membangun karakter nasionalis pada era sekaarang sangatlah penting. Upaya tersebut efektif dilaksanakan dalam pembelajaran disekolah dengan dukungan materi ajar yang menarik. Materi IPS khususnya tokoh-tokoh proklamasi merupakan contoh karakter nasionalis yang dapat di tauladani siswa. Pelaksanaan penelitian ini untuk mendeskripsikan: proses pengembangan, kelayakan, kepraktisan, dan keefektifan bahan ajar ensiklopedia berkarakter nasionalisme. Penelitian pengembangan ini menggunakan model 4D (four-D) yang dimodifikasi menggunakan tiga tahapan saja, yaitu: tahap pendefinisian, tahap perancangan, dan tahap pengembangan. Subjek uji coba adalah 19 siswa kelas V SDN Sengguruh. Instrumen pengumpulan data menggunakan angket dan dokumentasi. Hasil penelitian menunjukkan bahwa bahan ajar ensiklopedia layak, praktis dan efektif untuk digunakan. Penilaian oleh ahli media mendapatkan presentase 80%, ahli bahasa mendapatkan presentase 80%, penilaian ahli materi mendapatkan presentase 77,2 %, penilaian praktisi mendapatkan presentase 95,4 %, penilaian siswa mendapatkan presentase 92%, sedangkan untuk keefektifan mendapatkan 78,5%. Berdasarkan paparan hasil penilaian maka bahan ajar ensiklopedia “Layak” dan “Sangat Baik” digunakan di lapangan
The importance of building nationalist character in the present era is very important. These efforts are effectively implemented in school learning with the support of interesting teaching material. IPS material, especially the figures of the proclamation, are examples of nationalist characters that can be taught by students. The implementation of this research is to describe: the process of developing, feasibility, practicality, and effectiveness of encyclopedia teaching materials characterized by nationalism. This development research uses a 4D (four-D) model that is modified using only three stages, namely: the stage of defining, designing, and developing. The subjects of the trial were 19 fifth grade students at Sengguruh Elementary School. The instrument of data collection uses questionnaires and documentation. The results showed that encyclopedia teaching materials were feasible, practical and effective to use. Evaluation by media experts gets a percentage of 80%, linguists get 80% percentage, assessment of material experts get a percentage of 77.2%, practitioner assessment gets a percentage of 95.4%, assessment of students get a percentage of 92%, while for effectiveness get 78.5% . Based on the explanation of the results of the assessment, the encyclopedia teaching material "Worthy" and "Very Good" was used in the field
Regorafenib plus FOLFIRI with irinotecan dose escalated according to uridine diphosphate glucuronosyltransferase 1A1 genotyping in previous treated metastatic colorectal cancer patients: study protocol for a randomized controlled trial
Authors: Ma Cheng-Jen , Chang Tsung-Kun , Tsai Hsiang-Lin , Su Wei-Chih , Huang Ching-Wen , Yeh Yung-Sung , Chang Yu-Tang , Wang Jaw Yuan 
Published: July 2019

Abstract
Background

Regorafenib is an oral multi-kinase inhibitor for metastatic colorectal cancer (mCRC) previously treated with fluoropyrimidines, irinotecan, oxaliplatin, monoclonal antibodies targeting vascular endothelial growth factor (VEGF), and monoclonal antibodies targeting epidermal growth factor receptor (EGFR). A dose reduction from 160 mg to 120 mg regorafenib reduces regorafenib-associated adverse events (AEs). Dose adjustment of irinotecan in FOLFIRI regimen on basis of individual uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotype provides optimal oncological outcomes with acceptable AEs. This study is trying to address the efficacy and safety of dose adjusted combination of regorafenib and FOLFIRI for patients with mCRC.

Methods

A prospective, multicenter, randomized in a 2:1 ratio, controlled, clinical trial with two parallel arms will be conducted to compare irinotecan dose escalated FOLFIRI according to UGT1A1 genotyping plus 120 mg regorafenib with 120 mg regorafenib alone in previously treated patients with mCRC. The primary endpoint is progression-free survival (PFS) and the secondary endpoints are overall survival (OS), disease control rate (DCR), time to progression (TTP), and duration of treatment (DoT). Safety assessments are recorded as well.

Discussion

Dose adjustment for regorafenib and irinotecan makes treatment-related AEs tolerable and makes the concomitant treatment practicable. This study will provide initial evidences regarding the efficacy and safety of a new combination of chemotherapy and a targeted agent for mCRC.
Transcriptomic and proteomic analysis reveals mechanisms of pre-fertilization barriers during water lily cross breeding
Authors: Sun Chun-Qing , Chen Fa-Di , Teng Nian-Jun , Yao Yue-Mei , Shan Xi , dai zhongliang 
Published: July 2019

Abstract
Background

In water lily (Nymphaea) hybrid breeding, breeders often encounter non-viable seeds, which make it difficult to transfer desired or targeted genes of different Nymphaea germplasm. We found that pre-fertilization barriers were the main factor in the failure of the hybridization of Nymphaea. The mechanism of low compatibility between the pollen and stigma remains unclear; therefore, we studied the differences of stigma transcripts and proteomes at 0, 2, and 6 hours after pollination (HAP). Moreover, some regulatory genes and functional proteins that may cause pre-fertilization barriers in Nymphaea were identified.

Results

RNA-seq was performed for three comparisons (2 vs 0 HAP, 6 vs 2 HAP, 6 vs 0 HAP), and the number of differentially expressed genes (DEGs) was 8,789 (4,680 were up-regulated), 6,401 (3,020 were up-regulated), and 11,284 (6,148 were up-regulated), respectively. Using label-free analysis, 75 (2 vs 0 HAP) proteins (43 increased and 32 decreased), nine (6 vs 2 HAP) proteins (three increased and six decreased), and 90 (6 vs 0 HAP) proteins (52 increased and 38 decreased) were defined as differentially expressed proteins (DEPs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed that the DEGs and DEPs were mainly involved in cell wall organization or biogenesis, S-adenosylmethionine (SAM) metabolism, hydrogen peroxide decomposition and metabolism, reactive oxygen species (ROS) metabolism, secondary metabolism, secondary metabolite biosynthesis, and phenylpropanoid biosynthesis.

Conclusions

These results indicated that genes involved in regulation and gene pathways involved in stress response might overlap in the process of pollination process forming the hybridization barrier in Nymphaea. These results indicate that the pollen tube entering stigma tissue was very similar to the process of external injury, further suggesting that these genes involved in defense and stress response were necessary in the early stage of interaction between the pollen and stigma. This study strengthens our understanding of the mechanism of pre-fertilization barriers in Nymphaea at the molecular level, and provides a theoretical basis for overcoming the pre-fertilization barriers in Nymphaea in the future.
Choreographing life-experiences of balance control in people with Parkinson’s disease
Authors: LaGrone Sofie , Joseph Conran , Johansson Hanna , Enberg Birgit , Franzén Erika 
Published: July 2019

Abstract
Background
Parkinson’s disease (PD) is a devastating neurodegenerative disorder. Reduced balance is one of the cardinal symptoms of PD, predisposing people living with PD to experience difficulties with the execution of tasks and activities, as well as hindering their involvement in life situations.

Objective
The aim of this study was to explore how deficits in balance control manifest in everyday life and how it is managed by people with PD (PwPD).

Design
Qualitative description was used.

Methods
In-depth interviews were conducted with 18 participants, between the ages of 46 to 83 years, with mild to severe PD. Interview transcripts were analyzed using qualitative content analysis, following an inductive approach.

Results
One theme emerged from the analysis: Increased planning—choreographing life. Within this overarching theme, two categories were identified, namely Limitations in mobility and New restricted functioning in everyday life, each with 3-4 sub-categories. The categories described how PwPD handled decreased balance control in their everyday life by using motor and cognitive strategies as a consequence of not trusting their body’s capacity to control balance. Activities in everyday life, as well as the ability to partake in leisure and social activities were affected.

Conclusion
People with mild to severe PD used strategies to handle decreased balance and they choreographed their lives around their individual current state of mobility and balance. The knowledge gained from this study can be used to develop targeted interventions addressing the nuances of balance deficits in everyday life.
The effect of simulation-based education on student self-efficacy in the physiotherapy assessment and management of paediatric patients: An observational study
Authors: Hough Judith , Levan Daniel , Steele Michael , Kelly Kristine , Dalton Megan 
Published: July 2019

Abstract
The Australian Physiotherapy Council mandates that physiotherapy clinical education be sufficient to produce graduates who are competent to practice across the lifespan. Due to a lack of opportunities for paediatric clinical placements, there is a risk of graduates not having the opportunity to develop competency in paediatric physiotherapy. To address this risk, simulation-based education (SBE) has been proposed as an additional educational strategy, and despite encouraging evidence for its use in physiotherapy education, there is limited evidence supporting its use specifically in paediatric populations. The aims of this research were to investigate the effect of SBE on student self-efficacy in the physiotherapy assessment and management of paediatric clients, and to determine student satisfaction with SBE as a learning strategy. Three interactive SBE sessions were run during the undergraduate paediatric physiotherapy unit at the campus of one Australian university. Self-efficacy was surveyed before and after each session, to determine confidence in clinical skills, clinical decision-making, treatment preparation and planning, communication skills; evaluating and modifying interventions, and interprofessional practice. Student satisfaction with SBE as a learning strategy was surveyed after the final SBE session. For the 164 participants included in this study, self-efficacy survey response rate varied from 77-96% for each session. Significant increases in mean student self-efficacy were recorded for all questions (p<0.001). A total of 139 (85%) responded to the reactionnaire with 78.6% indicating they were very satisfied with SBE as a learning strategy. Written comments from 41 participants identified ‘experience’ as the primary theme.
Conclusion: SBE had a significant positive effect on student self-efficacy in the physiotherapy assessment and management of paediatric clients. Students also perceived SBE to be a valuable learning experience. Future research is needed to investigate whether SBE improves student performance and how SBE compares to standard educational methods.
Bacterial profile, antibiotic susceptibility pattern and associated risk factors of urinary tract infection among clinically suspected children attending at Felege-Hiwot Comprehensive and Specialized Hospital, Northwest Ethiopia. A prospective study
Authors: Fenta Adugna , Dagnew Mulat , Belachew Teshome , Eshetie Setegn 
Published: July 2019

Abstract
Background

Urinary tract infection is one of the most common bacterial infections in children. Understanding the characteristics of uropathogens and their antimicrobial susceptibility pattern in a particular setting can provide evidence for appropriate management of cases. The aim of this study was to assess the bacterial profile of urinary tract infection, their antimicrobial susceptibility pattern and associated factors among clinically suspected children attending at Felege-Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia.

Methods

A hospital-based cross-sectional study was conducted from February-April, 2019. A systematic sampling technique was employed. A mid-stream urine sample was inoculated on cystine lactose electrolyte deficient media and incubated for 24-48 hours.Sub culturing was done on Mac-Conkey and blood agar. Antimicrobial susceptibility test was done on Muller-Hinton agar. A binary logistic regression model was used to see the association between dependent and independent factors.A p-value<0.05 at 95% CI was considered as statistically significant.

Results

The overall prevalence of urinary tract infection was 16.7% (95% CI 12.4-21.1). Both Gram-negative and Gram-positive bacterial isolates were recovered with the rate of 44/50 (88%) and 6 (12%) respectively. Among Gram-negative isolates, E.coli (56%) was the predominant while S. saprophyticus(6%) wasprevalent among Gram-positive bacterial isolates.Overall, a high level of resistance to ampicillin, Augmentin, and tetracycline was observed with the rate of 100%, 68.16%, 65.91% respectively. About 66% of multidrug resistance was observed (95% CI 52-78). Having a history of urinary tract infection (P-0.003, AOR 1.86-22.15) and male uncircumcision(p-0.00, AOR 5.5-65.35) were the independent variables that associate for urinary tract infections.

Conclusion

The prevalence of urinary tract infection among children was high and considerably a high proportion of multidrug resistance was observed in the present study. This result will have a significant impact on selection of appropriate antimicrobial agents for the treatment of urinary tract infection.