bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-analysis identifies microbial signatures of disease in murine models of inflammatory bowel disease
Authors: Saha Sudipta , Martin Alberto , Navarre William Wiley 
Published: January 2019

ABSTRACTThe gut microbiota plays a central role in modulating intestinal inflammation, but the identification of specific inflammation-associated microbes has remained elusive. Here, we perform a meta-analysis on metagenomic data from 12 different studies of murine colitis triggered by a variety of genetic and environmental factors with the goal of finding bacterial taxonomic groups that can act as signatures of health or disease across studies, and that can be used to discriminate between healthy and diseased mice. We leveraged recent developments in 16S analysis tools to identify amplicon sequence variants (ASVs) instead of the traditional Operational Taxonomic Units, and used the EZTaxon reference database that distinguishes between currently unnamed and uncharacterized 16S phylotypes. Random Forest model and differential abundance analysis were used to detect microbial signatures that could consistently differentiate healthy from diseased mice, and a ‘dysbiosis index’ was constructed from these. This dysbiosis index was able to correctly distinguish samples derived from inflamed and non-inflamed mice in the majority of studies and significantly outperformed other frequently used metrics of dysbiosis including alpha-diversity, proteobacterial abundance, and the ratio of Bacteroidetes to Firmicutes. 10 of 12 bacteria we identify as associated with the diseased state are members of the order Bacteroidales, including several species from the abundant but poorly understood S24-7 family. The implications of these findings are discussed.
Interactions between dosage compensation complex components Msl-1, Msl-2 and NURF component NURF301 with long non-coding RNA genehsrω
Authors: Chaturvedi Deo Prakash 
Published: January 2019

AbstractHyperactivity of the single X-chromosome in maleDrosophilais achieved by establishing a ribonucleoprotein complex, called Dosage Compensation Complex (DCC), on the male X chromosome. Msl-1 and Msl-2 proteins, involved in the initiation and establishing of DCC on male X chromosome, are very crucial component of this complex. In the present study, it has been found here that a long non-coding RNA genehsrωgenetically interacts with Msl-1 as well as Msl-2 and suppresses the lethal phenotype of Msl-1 or Msl-2 down-regulation in its up-regulated background. Additionally, it is also found here that an ATP-dependent chromatin remodeler, NURF301, also interacts withhsrωin same manner. General lethality caused byAct-GAL4driven global expression ofNURF301-RNAiand the male-specific lethality followingMsl-1-RNAiorMsl-2-RNAitransgene expression were partially suppressed by over-expression ofhsrω, but not by down regulation throughhsrω-RNAi. Likewise, eye phenotypes followingey-GAL4driven down-regulation ofNURF301orMsl-1orMsl-2were also partially suppressed by over-expression ofhsrω.Act-GAL4driven global over-expression ofhsrωalong withMsl-1-RNAiorMsl-2-RNAitransgene substantially restored levels of MSL-2 protein on the male X chromosome. Similarly, levels and distribution of Megator protein, which was reduced and distribution at nuclear rim and in nucleoplasm was affected in the MT and SG nuclei, is also restored when hsrω transcripts are down-regulated inAct-GAL4drivenMsl-1-RNAiorMsl-2-RNAigenetic background. NURF301, a known chromatin remodeler, when down-regulated shows decondensed X chromosome in male larvae. Down-regulation of hsrω results in restoration of chromosome architecture without affecting the level of ISWI protein-another chromatin remodeler protein, known to interacting with hsrω.
Integrative methylome and transcriptome analysis of Japanese flounder (Paralichthys olivaceus) skeletal muscle during development
Authors: Zhang Jingru , Wu Shuxian , Huang Yajuan , Wen Haishen , Zhang Meizhao , Li Jifang , Li Yun , Qi Xin , He Feng 
Published: January 2019

AbstractDNA methylation is an important epigenetic modification in vertebrate and is essential for epigenetic gene regulation in skeletal muscle development. We showed the genome-wide DNA methylation profile in skeletal muscle tissue of larval 7dph (JP1), juvenile 90dph (JP2), adult female 24 months (JP3) and adult male 24 months (JP4) Japanese flounder. The distribution and levels of methylated DNA within genomic features (1stexons, gene body, introns, TSS200, TSS1500 and intergenic) show different developmental landscapes. We also successfully identified differentially methylated regions (DMRs) and different methylated genes (DMGs) through a comparative analysis, indicating that DMR in gene body, intron and intergenic regions were more compared to other regions of all DNA elements. A gene ontology analysis indicated that the DMGs were mainly related to regulation of skeletal muscle fiber development process, Axon guidance, Adherens junction, and some ATPase activity. Methylome and transcriptome clearly revealed a exhibit a negative correlation. And integration analysis revealed a total of 425, 398 and 429 negatively correlated genes with methylation in the JP2_VS_JP1, JP3_VS_JP1 and JP4_VS_JP1 comparison groups, respectively. And these genes were functionally associated with pathways including Adherens junction, Axon guidance, Focal adhesion, cell junctions, Actin cytoskeleton and Wnt signaling pathways. In addition, we validated the MethylRAD results by bisulfite sequencing PCR (BSP) in some of the differentially methylated skeletal muscle growth-related genes (Myod1, Six1 and Ctnnb1). In this study, we have generated the genome-wide profile of methylome and transcriptome in Japanese flounder for the first time, and our results bring new insights into the epigenetic regulation of developmental processes in Japanese flounder. This study contributes to the knowledge on epigenetics in vertebrates.Author summaryEpigenetic mechanisms like DNA methylation have recently reported as vital regulators of some species skeletal muscle development through the control of genes related to growth. To date, although genome-wide DNA methylation profiles of many organisms have been reported and the Japanese flounder reference genome and whole transcriptome data are publically available, the methylation pattern of Japanese flounder skeletal muscle tissue remains minimally studied and the global DNA methylation data are yet to be known. Here we investigated the genome-wide DNA methylation patterns in Japanese flounder, throughout its development. These findings help to enrich research in molecular and developmental biology in vertebrates.
How knowledge sharing connects interpersonal trust and innovation capability
Authors: Lei Hui , Nguyen Thuong Thi , Le Phong Ba 
Published: January 2019

PurposeKnowledge sharing (KS) and innovation are generally believed as the antecedents of key outcomes that help firms to attain and sustain competitive advantage in long term. The purpose of this paper is to analyze the mechanism of how interpersonal trust and leader support affect KS and improve firm’s innovation capabilities.Design/methodology/approachThis is a research paper which is built using empirical data collected from 68 manufacturing and service firms in China.FindingsFirst, the findings show that leader supports moderate the correlation between interpersonal trust and KS. Second, KS serves as mediator in the relationship between interpersonal trust and firm’s innovation capabilities.Research limitations/implicationsKS plays a crucial role in stimulating innovation capabilities for both manufacturing and service firms. Future research should explore the effects of the motivational factors (such as positive psychological state, perceived benefits and costs) on KS and firm’s innovation capabilities.Practical implicationsThe paper provides the evidence for the positive effects of interpersonal trust on KS, which in turn is significantly associated with product innovation and process innovation. It highlights the important role of leader supports in promoting the degree of sharing knowledge among individuals to enhance innovation capabilities for firms.Originality/valueThis study puts the theory of innovation forward based on exploring the key factors that have potential and positive impacts on two specific types of innovation capability, namely, product innovation and process innovation, for both manufacturing and service firms.
The effects of finishing processes on the dynamic drape of wool fabrics
Authors: Eryuruk Selin Hanife , Kursun Bahadir Senem , Saricam Canan , Kalaoglu Fatma 
Published: January 2019

Purpose
The purpose of this paper is to analyse dynamic drape behaviour of eight different types of woollen fabrics each treated by three different finishing processes.

Design/methodology/approach
A new apparatus was used to evaluate the dynamic drape formation process of woollen fabrics during the rotation of the samples at different speed grades of 0 (static drape), 30, 60, 90, 120, 150 and 180 rev/min for each sample. The computerised image analysis method was used to measure the drape coefficients (DCs).

Findings
As a result of experiments, it was found that shearing, calendaring, pressing processes affected the drapability and drape behaviour negatively, but belt pressing treatment and decatising process improved the drapability and the drape behaviour for all fabrics. Furthermore, there is a reverse relationship between fabric weight and drape behaviour. As the fabric weight increases, DC value increases due to the increase of fabric tightness.

Originality/value
To date, although many researchers have studied the static draping behaviour, the studies regarding the dynamic drape behaviour of the fabrics are quite limited to an extent. Besides, none of these studies regarding the drape behaviour have investigated the effects of different finishing processes on the drape behaviour of wool fabrics.
On the economic consequences of automation and robotics
Authors: Gomes Orlando , Pereira Sónia 
Published: January 2019

Purpose
The academic literature is currently placing significant attention on the study of the socio-economic consequences of the observable fast automation of all sectors of economic activity. The purpose of this paper is to systematize meaningful ideas on the economic impact of the rise of the robots.

Design/methodology/approach
With the goal of evaluating the channels through which the current wave of fast technological change affects the organization and performance of the economy and the behavior of agents, the paper is structured into two parts. The first part assesses the state of knowledge regarding the potential revolutionary role of robot use in production. The second part designs a model aimed at exposing the interplay between the most prominent features associated with the new economic reality.

Findings
The current wave of innovation has implications that escape conventional economic thinking. The evaluation and prediction of what the new phenomena brings is fundamental to design policies that prevent income inequality to widen and growth to slow down.

Research limitations/implications
The full macroeconomic impact of the fast, pervasive and irreversible automation of production is far from being completely assimilated. At this level, no benchmark model should be interpreted as a definitive framework of analysis, and economic thought should evolve alongside with empirically observed evidence.

Originality/value
We are facing an automation convulsion that replaces humans by machines at an unprecedented fast rate. This paper systematizes ideas about this process and offers a novel conceptual model to better understand what really is at stake.
Knowledge, attitude and practice (KAP) of earthquake preparedness amongst the elderly in risk areas
Authors: Songlar Tanika , Pussadee La-or Nicharuch Panjaphothiwat , Chomchoe Chalitar , Khunthason Siriyaporn 
Published: January 2019

PurposeChiang Rai being an earthquake-prone city, it is essential to raise awareness about earthquake safety and readiness, especially amongst the elderly population who spend most of their time at home. The purpose of this paper is to evaluate the earthquake preparedness of elders in relation to knowledge, attitude and practice.Design/methodology/approachThis was an analytic cross-sectional study. Research data were collected from 480 elders of 60 years old and above. The research instruments were questionnaires about knowledge, attitude and self-assessment of practices in earthquake situations. Data were analyzed by number, percentage and aχ2test.FindingsOf participants interviewed, 39.4 percent were aged between 60 and 66 years old. Overall, 94.0 percent of them had already experienced an earthquake, with 79.4 percent having experienced it in 2014. Participants had a good level of knowledge and attitude toward earthquake safety. Their practices toward earthquake readiness, however, were insufficient due to the lower practice scores (<12), especially found in the high seismic zone. The score level of knowledge, attitude and self-assessment of practice in earthquake situations showed that there is a difference in statistical significance (p<0.05).Originality/valueThis study focuses attention on the need to increase levels of preparedness. Safety instructions and earthquake drills should be promoted and supported in order to prepare elders for an earthquake in the study area. Research findings identified in this study will help to address the specific needs of the elderly when implementing an earthquake disaster risk reduction plan.
A resource-based framework for strategically managing identity
Authors: Rockwell Sam 
Published: January 2019

Purpose
The purpose of this paper is to blend a resource-based view of the firm with the 5R Model of Organizational Identity Processes to offer a new Strategic Identity Management Framework to help organizations uncover, analyze and optimize their identity as a resource for creating sustainable competitive advantage.

Design/methodology/approach
This conceptual paper relied upon an examination of literature about sustainable competitive advantage, the resource-based view of the firm and the 5R Model of Organizational Identity Processes.

Findings
Synergies were found between the VRIO model and the 5R Model of Organizational Identity Processes. A new Strategic Identity Management Framework was created and a case study was used to illustrate its application.

Research limitations/implications
Research is needed to validate, confirm and extend the use and application of the new framework within organizations.

Practical implications
The framework is anticipated to be particularly useful for middle managers because they are tasked with translating high-level strategies into action and leading lower level employees toward enacting the new or adapted identity claims.

Originality/value
Although ample organizational identity research exists, a framework for assessing identity claims for the purpose of achieving competitive advantage was lacking.
On becoming an organizational autoethnographer
Authors: Armstrong-Gibbs Fiona 
Published: January 2019

Purpose
The purpose of this paper is to explore the process and challenges of applying an autoethnographic research method to a professional doctoral thesis ethics application. It examines the traditional university ethical approval process and if it is appropriate for this evolving qualitative research method within an organizational context.

Design/methodology/approach
A short introduction to the literature on ethics prefaces an autoethnographic account of the author’s experience as doctor of business administration candidate tackling the application process for ethical approval of primary research. The account is a reflection of the review process and critiques with reference to the existing literature.

Findings
The majority of the literature relating to ethics has focused on the private, personal and largely evocative accounts of autoethnography. This paper highlights some of the differences and potential for organizational autoethnography and ethical conduct. It highlights the ethical implications of obtaining consent from one’s colleagues, developing and maintaining dependent relationships, risk and reward to one’s own professional reputation and becoming equipped to create both personal and organizational change through a process of reflexivity.

Originality/value
This paper adds to the discussion about ethical conduct when undertaking new forms of organizational ethnographic research. For those interested or involved in the university institutional ethics review committees and for professional doctoral students who are developing an emancipatory insider research approach.
Analysis of the association between economic growth, environmental quality and health standards in the Gulf Cooperation Council during 1980-2012
Authors: Bader Yasmeen , Ganguli Subhadra 
Published: January 2019

PurposeThe purpose of this paper is to investigate the validity of the environmental Kuznets curve (EKC) between gross domestic product (GDP) per capita and environmental indicators in the Gulf Cooperation Council (GCC) countries. Additionally, this paper also explores the relationship between health and income levels in the GCC to identify whether higher incomes necessarily affect overall health metrics.Design/methodology/approachThe first part of this paper studies the relationship between GDP per capita and the greenhouse gases (GHGs) – carbon dioxide (CO2), nitrous oxide (N2O) and methane (CH4) (all per capita data). The second part of this paper explores the relationship between GDP per capita and the following health variables: life expectancy, infant mortality and child mortality – for GCC countries during 1980–2012. Unit root tests were conducted, followed by cointegration analysis, leading to Granger causality test and vector error correction model.FindingsGCC states are highly dependent on fossil fuel production and hence depend on hydrocarbons for GDP growth. Most of the GCC states demonstrate lack of the EKC curve. However, there is evidence of U-shaped relationship between environmental pollutants and GDP per capita in kingdoms like Bahrain and Saudi Arabia (KSA). United Arab Emirates (UAE), on the other hand, demonstrates EKC, though not significantly. The study then explores the existence of potential relationship between health and GDP in the GCC, where it has been found that higher incomes have driven a better standard of living resulting in improved health metrics and higher life expectancy rates. Thus, growing incomes have played a positive role by improving health parameters and by offsetting some of the negative impacts from lack of environmental improvement as demonstrated by the absence of EKC in general in GCC.Originality/valueGHG emissions data are individually and empirically examined for each country in the GCC. Furthermore, the study delves into the environmental problems that lead to health issues, which were initially caused by pollution. The results of the empirical analysis provide strong evidence that GCC countries need to rely less on fossil fuels, as lower productivity due to higher pollution reduces income and economic growth in most countries.
Form and function of tropical macroalgal reefs in the Anthropocene
Authors: Fulton Christopher J. , Abesamis Rene A. , Berkström Charlotte , Depczynski Martial , Graham Nicholas A. J. , Holmes Thomas H. , Kulbicki Michel , Noble Mae M. , Radford Ben T. , Tano Stina , Tinkler Paul , Wernberg Thomas , Wilson Shaun K. 
Published: January 2019

Abstract

Tropical reefs have been subjected to a range of anthropogenic pressures such as global climate change, overfishing and eutrophication that have raised questions about the prominence of macroalgae on tropical reefs, whether they pose a threat to biodiversity, and how they may influence the function of tropical marine ecosystems.

We synthesise current understanding of the structure and function of tropical macroalgal reefs and how they may support various ecosystem goods and services. We then forecast how key stressors may alter the role of macroalgal reefs in tropical seascapes of the Anthropocene.

High levels of primary productivity from tropical canopy macroalgae, which rivals that of other key producers (e.g., corals and turf algae), can be widely dispersed across tropical seascapes to provide a boost of secondary productivity in a range of biomes that include coral reefs, and support periodic harvests of macroalgal biomass for industrial and agricultural uses. Complex macroalgal reefs that comprise a mixture of canopy and understorey taxa can also provide key habitats for a diverse community of epifauna, as well as juvenile and adult fishes that are the basis for important tropical fisheries.

Key macroalgal taxa (e.g., Sargassum) that form complex macroalgal reefs are likely to be sensitive to future climate change. Increases in maximum sea temperature, in particular, could depress biomass production and/or drive phenological shifts in canopy formation that will affect their capacity to support tropical marine ecosystems.

Macroalgal reefs can support a suite of tropical marine ecosystem functions when embedded within an interconnected mosaic of habitat types. Habitat connectivity is, therefore, essential if we are to maintain tropical marine biodiversity alongside key ecosystem goods and services. Consequently, complex macroalgal reefs should be treated as a key ecological asset in strategies for the conservation and management of diverse tropical seascapes.

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