bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ulmus minor bark hydro-alcoholic extract ameliorates histological parameters and testosterone level in an experimental model of PCOS rats
Authors: Hoseinpour Mohammad Javad , Ghanbari Alireza , Azad Nahid , Zare Ali , Abdi Shabnam , Sajadi Ensieh , Abbaszadeh Hojjat-Allah , Farahani Reza Mastery , Abdollahifar Mohammad-Amin 
Published: August 2019

Abstract

Objective. Polycystic ovary syndrome (PCOS) is a common and multifactorial disease associated with female factor infertility. Ulmus minor bark (UMB) is one of the medicinal plants used in Persian folklore as a fertility enhancer. In the current study, we aimed to elucidate the effect of UMB hydro-alcoholic extract on histological parameters and testosterone condition in an experimental model of PCOS rats.

Methods. Thirty female rats were randomly divided into five groups: (1) control, (2) vehicle, (3) PCOS/50 mg [6 mg/kg dehydroepiandrosterone (DHEA) + 50 mg/kg UMB hydro-alcoholic extract], (4) PCOS/150 mg (6 mg/kg DHEA + 150 mg/kg UMB hydro-alcoholic extract), and (5) PCOS (6 mg/kg DHEA). All interventions were performed for 21 days. Afterwards, stereological analysis was done for determination of ovarian volume and follicle number. The serum level of testosterone was measured by ELISA kit.

Results. UMB hydro-alcoholic extract improved the total number of the corpus luteum in the treatment groups when compared to the PCOS group (p<0.05). PCOS/150 mg and PCOS/50 mg groups showed significantly lower total number of the primordial, primary, and secondary follicles as well as testosterone level compared to the PCOS group (p<0.05). The total number of antral follicles and volume of ovary did not differ significantly between groups.

Conclusion. UMB extract may be an effective and good alternative in improving PCOS histo-logical and testosterone disturbances although further studies are warranted to confirm the safety of UMB plant in human.
Spatial relationship between the c-Fos distribution and enkephalinergic, substance P, and tyrosine hydroxylase innervation fields after acute treatment with neuroleptics olanzapine, amisulpride, quetiapine, and aripiprazole in the rat septum
Authors: Kiss Alexander , Osacka Jana 
Published: August 2019

Abstract

Objective. The aim of the present study was to demonstrate the spatial relationship between the c-Fos immunoreactive cells elicited by an acute treatment with neuroleptics including amisulpride (AMI), olanzapine (OLA), quetiapine (QUE), and aripiprazole (ARI) and enkephalinergic (ENK), substance P (SP), and tyrosine hydroxylase (TH) innervation fields in the rat septum.

Methods. Male Sprague Dawley rats received a single injection of OLA (5 mg), ARI (10 mg), AMI (20 mg), QUE (15 mg/kg/b.w.). Ninety min after antipsychotics administration, the animals were transcardially perfused with a fixative and the brains cryocut into serial coronal sections of 35 µm thickness. The sections were processed for c-Fos staining using an avidin-biotin-peroxidase complex and visualized by nickel intensified diaminobenzidine to reach black endproduct. Afterwards, the sections were exposed to ENK, SP, and TH antibodies and the reaction product visualized by biotin-labeled fluorescent AlexaFluor 564 dye. The data were evaluated from the sections either simultaneously illuminated with fluorescent and transmission microscope beams or after merging the separately illuminated sections in the Adobe Photoshop 7.0 software.

Results. ENK, SP, and TH displayed characteristic spatial images formed by a dense accumulation of immunoreactive fibers and terminals on the both sides of the septum. A dense plexus of axons formed by ENK and SP immunopositive terminals were situated predominantly in the lateral, while TH ones more medial portion of the septum. QUE and AMI activated distinct amount of c-Fos expression in cells located within the SP-immunoreactive principal innervation field. The OLA effect on the c-Fos expression was very pronounced in the ventral TH-labeled principal innervation field including the space between the ENK field ventral portion and the dorsal margin of the accumbens nucleus shell. Generally, the occurrence of c-Fos cells in the ENK-immunoreactive principal innervation field, in comparison with the surrounding septal area, was less abundant after all of the four antipsychotics treatments.

Conclusion. The data of the present study indicate that ENK, SP, and TH innervation fields may influence separate populations of septal cells activated by AMI, OLA, QUE, and ARI and that each of these region-differently innervated cells may be associated with the functional heterogeneity of the individual lateral septal nuclei.
Sex and salt intake dependent renin-angiotensin plasticity in the liver of the rat
Authors: Pidikova Paulina , Svitok Pavel , Herichova Iveta 
Published: August 2019

Abstract

Objective. Epidemiological studies confirm that hypertensive patients respond differently to renin-angiotensin system (RAS) inhibition depending on their gender. The aim of present work is to focus on sex-dependent differences in RAS regulation under conditions of increased salt intake.

Method. To investigate RAS, we measured the expression of angiotensinogen (Agt) mRNA, angiotensin receptor type 1 (AT1) mRNA and mitochondria assembly receptor (MasR) in the liver of rats under control conditions and after feeding with a salt diet (2% NaCl). In parallel, vascular endothelial growth factor A (VEGF-A) mRNA was analyzed.

Results. Regression analysis revealed sex-dependent differences in the correlation between mRNA expression of AT1 and that of Agt, MasR and VEGF-A in both groups. There was a significant negative correlation between AT1 and Agt mRNA expression in the male control group, but this correlation disappeared in males exposed to a salt diet. In females, AT1 and Agt expression correlated only in the group exposed to the salt diet. In control males, there was a borderline trend to correlation between AT1 and MasR mRNA expression. The correlation between AT1 and VEGF-A mRNA expression was significant only in the control females, however, after exposure to a salt diet, this correlation diminished.

Conclusions. We hypothesize that RAS components expression is compensated differently in males and females. The observed loss of compensatory relationships in RAS between AT1 and Agt and AT1 and MasR in male rats under a salt diet can contribute to the differences observed in human with hypertension associated with an unhealthy diet.
Efficacy and safety of dulaglutide in patients with absolute insulin deficiency
Authors: Kutoh Eiji , Hayashi Jyunka , Kuto Alexandra N. 
Published: August 2019

Abstract

Objective. While dulaglutide has been approved inpatients with type 2 diabetes (T2DM) in combination with insulin, it has not been studied in insulin-deficient patients, not whether they have type 1 diabetes (T1DM) or T2DM. The aim of this study is to assess the efficacy and safety of dulaglutide 0.75 mg/once weekly (QW) in patients with absolute insulin deficiency (n=10).

Subjects and Results. Significant reductions of HbA1c (9.30±1.03% to 8.61±1.21%; p<0.02) and body mass index (BMI; 23.61±3.95 to 23.41±4.24; p<0.02) levels were observed at 3 months with the addition of dulaglutide to the existing pharmacotherapy. However, in all the patients, post-meal C-peptide levels remained undetectable. One patient had gastrointestinal adverse events and discontinue dulaglutide within the first month. One patient was a non-responder, who had little if any changes in HbA1c levels at 3 months.

Conclusions. The results indicate that dulaglutide is effective in patients with T1DM or T2DM with absolute insulin deficiency, though gastrointestinal adverse events might be of concern. The improvements in glycemic control could not be due to enhanced insulin secretion, but may be as a result of a combination of the other effects of glucagon like peptide 1 (GLP-1), such as postprandial glucagon suppression, delayed gastric emptying, and weight loss.
Pheochromocytoma
Authors: Farrugia Frederick-Anthony , Charalampopoulos Anestis 
Published: August 2019

Abstract
Pheochromocytomas are rare tumors originating in the adrenal medulla. They may be sporadic or in the context of a hereditary syndrome. A considerable number of pheochromocytomas carry germline or somatic gene mutations, which are inherited in the autosomal dominant way. All patients should undergo genetic testing. Symptoms are due to catecholamines over production or to a mass effect. Diagnosis is confirmed by raised plasma or urine metanephrines or normetanephrines. Radiology assists in the tumor location and any local invasion or metastasis. All the patients should have preoperative preparation with α-blockers and/or other medications to control hypertension, arrhythmia, and volume expansion. Surgery is the definitive treatment. Follow up should be life-long.
Semantics and pragmatics of the lexemeposledný[the last] in discursive contexts
Authors: Sokolová Jana 
Published: August 2019

AbstractThe study attempts to interpret meanings of the Slovak lexemeposledný[the last]. The study is based on the fact that the lexeme has two kinds of semantic valence; that of a sequence element and that of a sequence. In the language picture of the world, this lexeme anticipates ideas of a wide range of collocates and syncretism of several types of sequence. Analyses are based on the invariant meaning of the lexeme “the last” (‘such an X that is not followed by any other’) and on corpus data. The data are used in order to determine how types of collocates in the constructions with ‘last’ do reflect modifications of the invariant meaning, how they are being specified referentially, and how they develop semantic and pragmatic inferences, by means of which they facilitate realization of specific semantic occurrences. Since the lexeme has an anthropological basis, it is expected that various portions and efficiency of the subjective factor will be found. The aim of the study is to present the paradigm of the meanings of the lexemeposlednýwhich are both context-bound and characterized by oscillation between description and qualification. Being a part of noun phrases, these meanings reflect linguistics of constructions as well as syntactic and communicative functions of the lexeme. The aim of the study is also either to confirm or disprove the equal position of the lexemesposlednýandostatný.
Adverbial intensifiers in contemporary Polish and Slovak
Authors: Sojda Sylwia 
Published: August 2019

Abstract
The paper discusses the intensifying functions of some lexical units derived from adverbs in a cross-linguistic Polish-Slovak perspective. The expression of intensification in Polish and Slovak has not been widely explored, which is why the present paper aims to point out a few aspects of this phenomenon in two closely related Slavic languages, which may contribute to help fill this gap. Intensification is without doubt a very interesting, pervasive and complex phenomenon in linguistics and is understood here as the process of quantitative change of a feature, activity or state. That change refers to the increase and decrease in intensity of a feature/activity/state according to an approved canon. The components of the category of intensification are therefore both, intensifying and deintensifying. Therefore, it is also postulated that a class of intensifiers/deintensifiers should be distinguished as means of intensification/deintensification. Intensifiers have also been a long fruitful topic of investigation in sociolinguistic research: on one hand intensification systems are unstable and tend to change rapidly in any speech community and on the other, the use of intensifiers tends to vary across demographic categories, especially age and gender. Intensification can also be researched due to ‘delexicalization’, which is defined as the reduction of the independent lexical contents of a word, or group of words, so that it comes to fulfil a particular function – the original meaning of the word is gradually lost as it evolves into a marker of intensification. The paper aims also to show that the more delexicalized an intensifier becomes, the more it will lose its lexical restrictions and increase in frequency. Through frequency of use and over time, intensifiers tend to lose their intensifying force and the renewal process occurs. This process promotes other adverbs, be they newly created adverbs or already existing ones, to the rank of intensifiers – it seems that the class of intensifiers may be an open class. The undertaken analysis has shown that there are a number of aspects which can be considered while describing intensifiers.
Lexical Atlas of the Russian Dialects – a new step to Slavonic linguogeography
Authors: Dvornická Ľubica 
Published: August 2019

Abstract
The methods of geolinguistics offer the possibility to study the geographical spread of dialect phenomena. The paper focuses on the presentation of the new Russian linguogeographic work Lexičeskij atlas russkich narodnych govorov [Lexical Atlas of the Russian National Dialects], namely the first volume – Planthood. Some aspects of the atlas conception are compared with other atlas works that are known and used or even prepared in the Slovak linguistic context: Atlas slovenského jazyka [Atlas of the Slovak Language], Český jazykový atlas [Czech Linguistic Atlas] and partially Slovanský jazykový atlas [Slavic Linguistic Atlas]. These works represent different periods in the development of linguistic geography methodology, so they represent different linguogeographic concepts.
Effectiveness of Automatic Correction of Systematic Effects in Measuring Chains
Authors: Dorozhovets Mykhaylo 
Published: August 2019

Abstract
The uncertainty of measurements associated with the following correction methods: advanced correction of additive linear drift, correction of additive and multiplicative effects, as well as joint correction of a linear drift and systematic additive and multiplicative effects is analyzed in the present article. For each correction method sensitivity coefficients and amplitude responses according to which noise and internal and external interferences influence the corrected measurement result have been determined. Besides uncertainty of reference quantities, the main factors which limit the efficiency of correction are: non-linearity of measurement function including non-linearity of ADC, no idealities of the switching systems and external and internal noises and periodic interferences. The efficiency of correction of systematic additive and multiplicative effects was studied for the multifunction 16 bit PCI DAQ of family NI 6250.
Experimental Measurement of Nanolayers via Electromagnetic, Near Infrared, and Gamma Radiation
Authors: Fiala Pavel , Bartušek Karel , Dědková Jarmila , Kadlec Radim , Dohnal Přemysl 
Published: August 2019

Abstract
We discuss and compare the results obtained from experimental measurements of a two-layer, Ni and TiO2 nanometric structure deposited on siliceous glass. Utilizing previous theoretical models of multilayers or periodic systems and their verifications, the paper focuses on measurement in the NIR, visible, UV, X-ray, and gamma bands of the electromagnetic spectrum; the wavelength of the incident electromagnetic wave is respected. The proposed evaluation comprises a brief description of a Snell’s law-based semi-analytic model of electromagnetic wave propagation through a layered material. We also demonstrate the expected anti-reflective and shielding effects in the X-ray and gamma-ray bands, respectively.
Evaluation of Damage Indices for Rectangular Concrete-filled Steel Tube Structures
Authors: Guan Minsheng , Lin Siying , Du Hongbiao , Cui Jie , Yan Taizhou 
Published: August 2019

Abstract
The paper aims to select a simple and effective damage index for estimating the extent of damage of rectangular concrete-filled steel tube (RCFT) structures subjected to ground motions. Two experimental databases of cyclic tests conducted on RCFT columns and frames are compiled. Test results from the database are then used to evaluate six different damage indices, including the ductility ratio (μ), drift ratio, initial-to-secant stiffness ratio (DKJ
), modified initial-to-secant stiffness ratio (Dms
), energy coefficient (E), and the combined damage index (DPA
) as a benchmark indicator. Selection criteria including correlation, efficiency, and proficiency are utilized in the selection process. The optimal alternative for DPA
is identified on the basis of a comprehensive evaluation. The evaluations indicate that Dms
previously proposed by some of the authors is the most appropriate substitution of DPA
, followed by the drift ratio. For the case of the slenderness ratio less than or equal to 30, the same grades of relation between the investigated damage indices and the benchmark are observed. However, in the case of the slenderness ratio larger than 30, the drift ratio tends to be the optimal alternative. In most cases, μ is proved to be an inadequate replacement of DPA
.
The impact of demographic and clinical characteristics on diabetic painful neuropathy
Authors: Assunção António , Campos Dina , Marques Rui , Cunha Inês , Santos Patrícia , Martins Adriana , Gonçalves Ana Sofia , Rebelo Ana , Lima Carolina , Matos César , Prata Ana Cristina , Teixeira José Tiago , Duarte Luís , Belo Mariana , Figueiredo Patrícia , Rosa Tiago Letras 
Published: August 2019

Abstract

Introduction. Diabetic neuropathy (DN) is one of the most devastating complications of diabetes mellitus; however, in contrast to other countries, there are no scientific studies in Portugal evaluating the impact of demographic and clinical characteristics of this pathological entity. The aim of this study was to evaluate the impact of gender, metabolic control, age of diabetic patients, as well as time of disease progression, the appearance of complaints related to neuropathic pain.

Material and methods. A multicentre study with a non-probabilistic, convenience sample of 359 patients was performed employing the quantitative method, using the Statistical Package for Social Science 24 software. The p-value of p < 0.05 was defined to consider a result statistically significant. The Spearman correlation coefficient (r) was determined to determine the relationship between categorical variables.

Results. There was no statistically significant difference in the prevalence of DN between genders (p = 0.633 and r = 0.025). There was a statistically significant relationship between the value of HbA1c and DN, with p = 0.010 and r = 0.136. There is a relationship between age and complaints of neuropathic pain, with p = 0.034 and r = 0.112. The variable, time of disease progression, is also correlated with the appearance of complaints of neuropathic pain with p = 0.020 and r = 0.112.

Conclusion. The prevalence of neuropathic pain in subjects with diabetes is not negligible and is associated with modifiable risk factors that can be identified, possibly modified and prevented. The correct approach for these patients, which involves screening and early treatment, is decisive improving functionality and quality of life.
Correlations between weather parameters, atmospheric hydrogen sulphide level and vitamin B12 administration to H2S exposed workers
Authors: Borcan Livia-Cristina , Borcan Florin , Păuncu Elena-Ana , Tomescu Mirela Cleopatra 
Published: August 2019

Abstract
Hydrogen sulphide, a highly toxic gas, can be used in crenotherapy to balance all metabolic processes (minerals, fats and proteins). The main aims of this study were to correlate the weather characteristics with the atmospheric H2S level and to evaluate the antidote activity of B12 Vitamin in the case of prolonged exposure to this compound. 46 volunteers, people from the medical staff of an important Romanian thermal water spring spa, with professional exposure at H2S, were enrolled in this study; numerical data about their blood pressure, atmospheric H2S concentration and about the weather conditions were collected every month for one year. The results indicate an improvement in the blood pressure of volunteers treated with Vitamin B12; no significant correlation between the concentration of total urinary sulphur and the concentration of atmospheric H2S level was found.
Health particularities of the employees of clothing factories
Authors: Meșina Victor , Friptuleac Grigore 
Published: August 2019

Abstract
We present the particularities of the morbidity with temporary labor incapacity (TLI) of the employees of confection factories during the years 2011 - 2017. We placed emphasis on the risk factors affecting the health of the employees. It is an established fact that the main risk factors are unfavorable microclimate, vibration, dust, noise, and others. Morbidity with TLI according to frequency index (IFc) has practically a constant character. The highest level of IFc was registered in 2013, reaching 93.3 cases per 100 workers, while the severity index being oscillatory in nature constituted 1311.2 days in 100 workers in the same year. Both indices have shown a growth trend towards the end of 2017. The average duration of a case remained at the same level of 13-14 days. There were also particularities of morbidity based on gender, profession, etc. The data obtained can be the basis for the elaboration of the prophylaxis measures.
Prostate cancer: an occupational hazard in Romania?
Authors: Mateș Dana , Calotă Violeta Claudia , Oțelea Marina Ruxandra , Csiki Irma Eva , Rașcu Ștefan Alexandru , Staicu Cătălin Alexandru , Suciu Nicoleta , Voinoiu Angelica , Iordache Paul D. , Rașcu Agripina , Mateș Ioan Nicolae , Manolescu Andrei , Jinga Viorel 
Published: August 2019

Abstract
Several occupational carcinogens (arsenic, cadmium) and industries (rubber production) have been associated with prostate cancer risk but most of the data are from studies conducted on screened populations. Here we explored this association in Romanian men, a population with low PSA screening test coverage. We have analyzed 468 prostate cancer cases pathologically confirmed and 495 non-cancer hospital controls, recruited in the ROMCAN project. Personal information, including occupational activity, was collected through interview. Two experts classified jobs and activities into 15 economic sectors with similar patterns of exposure. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between ever employed in each economic sector and prostate cancer risk. We observed a higher non adjusted risk for employment in electricity, gas, steam and air conditioning supply activities (OR=3.95, p=0.029), manufacturing–light industry (OR=1.88, p=0.039), financial, insurance and gambling (OR=1.44, p=0.046) and a lower risk for employment in construction industry (OR=0.62, p=0.010). After adjusting for potential confounders, only the low risk in construction workers was maintained (OR=0.55, p=0.004). Our study provides some evidence on the role of occupational factors on the prostate cancer risk but further assessments are needed. Healthy lifestyle promotion and prevention should be reinforced at workplaces.