bluuebunny/crossref_metadata_2025_split huggingface dataset:
Near‐infrared fluorescence‐labeled anti‐PD‐L1‐mAb for tumor imaging in human colorectal cancer xenografted mice
Authors: Zhang Mingyu , Jiang Huijie , Zhang Rongjun , Jiang Hao , Xu Hailong , Pan Wenbin , Gao Xiaolin , Sun Zhongqi 
Published: January 2019

AbstractThe expression of programmed death ligand‐1 (PD‐L1) in tumor has been used as a biomarker to predict the anti‐PD‐L1 immunotherapy response. To develop a noninvasive imaging technique to monitor the dynamic changes in PD‐L1 expression in colorectal cancer (CRC), we labeled an anti‐PD‐L1 monoclonal antibody with near‐infrared (NIR) dye and tested the ability of the NIR‐PD‐L1‐mAb probe to monitor the PD‐L1 expression in CRC‐xenografted mice by performing optical imaging. Consistent with the expression levels of PD‐L1 protein in three CRC cell lines in vitro by flow cytometry and Western blot analyses, our in vivo imaging showed the highest fluorescence signal of the xenografted tumors in mice bearing SW620 CRC cells, followed by tumors derived from SW480 and HCT8 cell lines. We detected the highest fluorescent intensity of the tumor at 120 hours after injection of NIR‐PD‐L1‐mAb. The highest fluorescence intensity was seen in the tumor, followed by the spleen and the liver in SW620 xenografted mice. In SW480 and HCT8 xenografted mice, however, the highest fluorescent signals were detected in the spleen, followed by the liver and the tumor. Our findings indicate that SW620 cells express a higher level of PD‐L1, and the NIR‐PD‐L1‐mAb binding to PD‐L1 on the surface of CRC cells was specific. The technique was safe and could provide valuable information on PD‐L1 expression of the tumor for development of a therapeutic strategy of personized targeted immunotherapies as well as treatment response of patients with CRC.
Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia
Authors: Liu Pei , Zhang Hong‐Mei , Hu Ke , Zhou Xiu‐Fang , Tang Si 
Published: January 2019

AbstractChronic intermittent hypoxia (CIH) is known to induce hypertension, but the mechanism is not well understood. We hypothesized that sensory plasticity of the carotid body (CB) and oxidative stress in the paraventricular nucleus (PVN) are involved in CIH‐induced hypertension. In this study, rats were exposed to CIH for 28 days (intermittent hypoxia of 21% O2 for 60 s and 5% O2 for 30 s, cyclically repeated for 8 hr/day) and then randomly grouped for intracerebroventricular injection of 5‐HT2 receptor antagonist ritanserin, Rho‐associated protein kinase (ROCK) inhibitor Y‐27632, and NADPH oxidase (NOX) inhibitor diphenyleneiodonium (DPI), respectively. We found that CIH increased blood pressure (BP), elevated carotid sinus nerve (CSN) and renal sympathetic nerve (RSN) activities, oxidative stress, and cell apoptosis in PVN. NOX‐derived reactive oxygen species (ROS) production and cell apoptosis decreased when CIH‐induced activation of 5‐HT/5‐HT2AR/PKC signaling was inhibited by ritanserin. In addition, RhoA expression was downregulated when oxidative stress was attenuated by DPI, while Y‐27632 decreased the expression of endothelin‐1, which is overexpressed in the vascular wall during hypertension. Moreover, treatment with ritanserin, DPI or Y‐27632 attenuated the sensory plasticity and sympathetic hyperactivity as well as CIH‐induced elevation of BP. In conclusion, CIH‐induced activation of 5‐HT/5‐HT2AR/PKC signaling contributes to NOX‐derived oxidative stress in PVN, which may cause sensory plasticity of CB, RSN hyperactivity, and elevated BP.
Low expression of CRISP3 predicts a favorable prognosis in patients with mammary carcinoma
Authors: Wang Yanyan , Sheng Ning , Xie Ying , Chen Sihan , Lu Jun , Zhang Zifeng , Shan Qun , Wu Dongmei , Zheng Guihong , Li Mengqiu , Zheng Yuanlin , Fan Shaohua 
Published: January 2019

AbstractThe discovery of cysteine‐rich secretory protein 3 (CRISP3) has been made in human neutrophils for the first time. Cloning of the complementary DNA (cDNA) for CRISP3 was performed from a cDNA library of human bone marrow. In patients with mammary carcinoma, we found that lower expression of CRISP3 was connected to a significantly improved DFS (disease‐free survival) and OS (overall survival). Furthermore, the CRISP3 protein level was significantly associated with negative ANXA1 protein level. In addition, the heterogeneous expression of CRISP3 had been exhibited in diverse mammary carcinoma cells. A significant higher mRNA and the protein level of CRISP3 were seen in T‐47D as well as SK‐BR‐3 cells compared with those in other types of mammary carcinoma cells. Knockdown of CRISP3 in T‐47D or SK‐BR‐3 cells resulted in the weakened migration or invasion abilities. Furthermore, CRISP3 knockdown significantly inhibited the ERK1/2 MAPK signaling pathway in T‐47D or SK‐BR‐3 cells. Research results indicated that the lowering in the expression of CRISP3 is likely to serve as an unprecedented approach for the treatment of mammary carcinoma.
Clinical impact and cost‐effectiveness of noncontrast MRI in the evaluation of suspected appendiceal abscesses in children
Authors: Abdeen Nishard , Naz Fozia , Linthorst Rhys , Khan Usman , Dominguez Pablo Caro , Koujok Khaldoun , Bettoli Marcos , Shenouda Nazih 
Published: January 2019

BackgroundNoncontrast MRI has been shown to be feasible in children with postappendectomy abscesses and helps guide clinical management, but its role in preoperative appendiceal abscesses is unclear.PurposeTo determine the cost‐effectiveness and impact on clinical management of noncontrast MRI in pediatric patients with suspected appendiceal abscess, both pre‐ and postappendectomy.Study TypeRetrospective cohort study.PopulationIn all, 82 children under the age of 18 years with suspected appendiceal abscess on ultrasound.Field Strength/SequenceDiffusion‐weighted imaging and T2‐weighted single‐shot fast spin‐echo imaging of the abdomen and pelvis at 1.5T and 3T.AssessmentThe presence, location, size, and apparent diffusion coefficient (ADC) of fluid collections and the presence of a drainage path was noted by three pediatric radiologists. Imaging time, completeness of the exam, and impact on clinical management was recorded. The incremental cost‐effectiveness ratio was calculated for MRI relative to CT, taking into account hospital charges, radiation exposure, and risk of adverse reaction to iodinated contrast.Statistical TestsDescriptive statistics were used. Intraclass correlation coefficient and Fleiss' kappa were used to assess interobserver variation. Proportions were compared using Fisher's exact test (statistical significance at P < 0.05).ResultsMRI confirmed the presence of collections in most cases, with alternative diagnosis established in 10 patients (Tubo‐ovarian abscess n = 7, Crohn's disease, ileal anastomotic leak, and Birkitts lymphoma each n = 1). MRI showed the presence of a safe drainage pathway in 92–97% of pelvic abscesses and 86–98% of abdominal abscesses compared with 7–10% and 75–81%, respectively, for ultrasound. MR was cost‐effective compared with CT, taking into account the direct charges, risk of radiation induced cancer, and adverse reaction to iodinated contrast.Data ConclusionNoncontrast MR is cost‐effective and affects clinical management in a significant proportion of children with suspected appendiceal abscesses.Level of Evidence: 5Technical Efficacy: Stage 6J. Magn. Reson. Imaging 2019.
Psychometric Evaluation of an Alternate Scoring for the Remote Associates Test
Authors: Beisemann Marie , Forthmann Boris , Bürkner Paul‐Christian , Holling Heinz 
Published: January 2019

AbstractThe Remote Associates Test (RAT; Mednick, 1962; Mednick & Mednick, 1967) is a commonly employed test of creative convergent thinking. The RAT is scored with a dichotomous scoring, scoring correct answers as 1 and all other answers as 0. Based on recent research into the information processing underlying RAT performance, we argued that the dichotomous scoring may lead to a loss of potentially relevant information. Thus, we proposed an alternate scoring based on semantic similarity between the answer given by the participant and the correct solution using Latent Semantic Analysis (LSA; Landauer & Dumais, 1997). We evaluate the psychometric properties of the alternate LSA scoring and found evidence of construct validity for the LSA scoring which was comparable to findings for the standard scoring, but not better as we would have expected. Thus, our expectations that LSA‐based scoring of the RAT counteracts potential information loss were not met. However, LSA based scorings appear to be a promising alternative for hardly solvable RAT items. We conducted additional analyses comparing different RAT item types with regard to their validity as well as evaluating the information uniquely contained in the LSA scoring. Implications of all finding for existing research using RAT items are discussed.
Laundry Detergency of Solid Nonparticulate Soil or Waxy Solids: Part II. Effect of the Surfactant Type
Authors: Chanwattanakit Jarussri , Scamehorn John F. , Sabatini David A. , Chavadej Sumaeth 
Published: January 2019

AbstractIn this work, methyl palmitate with a melting point around 30°C was used as a model of waxy soil. Its detergency was evaluated with a hydrophilic surface (cotton) or a hydrophobic surface (polyester) using different surfactants: alcohol ethoxylate (EO9), sodium dodecyl sulfate (SDS), methyl ester sulfonate (MES), methyl ester ethoxylate (MEE), and two extended surfactants (C12,14‐10PO‐2EO‐SO4Na and C12,14‐16PO‐2EO‐SO4Na). The detergency efficiency at a 0.2 wt.% surfactant and 5 wt.% NaCl gradually increased while redeposition gradually decreased with increasing washing temperature in most studied surfactant solutions; this was observed both above and below the melting point of methyl palmitate on both studied fabrics. If the methyl palmitate was heated above the melting point when deposited on the fabric, it was better able to penetrate into the fabric matrix as compared to deposition below the melting point, resulting in poorer detergency for heated deposition, particularly for washing temperatures lower than the melting point. Among the surfactants studied, the nonionic surfactant (EO9) showed the highest detergency efficiency (73–94%) at any washing temperature especially on the polyester fabric. For washing temperatures below the melting point, detergency performance correlated well with the contact angle of surfactant solution on the solid methyl palmitate surface for all studied surfactants when salinity was varied. In this work, conditions resulting in the highest detergency below the melting point corresponded to the highest detergency above the melting point, suggesting this as a systematic approach to formulating below the melting point of the soil. Charge of particles or fabric was not observed to be important to the detergency mechanism, but steric factors resulting from surfactant adsorption were observed to be important mechanistic factors in waxy solid detergency.
Improving the prediction of the fatty acid profile of olive oils by considering statistically relevant harvests and agro‐climatic variables
Authors: Sánchez‐Rodríguez M Isabel , Caridad José M , Sánchez‐López Elena , Marinas Alberto , Urbano Francisco J 
Published: January 2019

AbstractBACKGROUNDFatty acids are the major components in extra virgin olive oil, and they are considered as a quality parameter to its authentication. As fraudulent practices are the most important problem in this sector, fast, reliable and cost‐effective techniques, such as Raman spectroscopy, have been successfully applied, in combination with chemometrics, to determine the fatty acid profile of oils.RESULTSThe huge amount of information provided by Raman spectra is reduced in a few orthogonal components of principal component analysis (PCA). The goodness‐of‐fit of the statistical models including only these PCA factors is considerably increased by introducing dummy variables, associated with the harvest, and some agro‐climatic variables (temperature, humidity, wind speed, radiation, precipitation and evapotranspiration). Many of these additional variables are statistically relevant in models using either the global sample or subsamples of Andalusian provinces or olive varieties.CONCLUSIONSThe regression models using only Raman spectral information are clearly improved by the consideration of harvesting time and agro‐climatic data, a useful result as trade standard applying to olive oils limits values for disaggregated fatty acids to authenticate olive oils. Nevertheless, the effect (or the statistical relevance) of these variables depends on the specific type of fatty acid, geographical region (province) or olive variety. © 2019 Society of Chemical Industry
Capacitive touchscreen‐integrated electrostatic tactile display with localized sensation
Authors: Haga Hiroshi , Sugimoto Daisuke , Yang Yiping , Sasaki Harue , Asai Takuya , Shigemura Koji 
Published: January 2019

AbstractAn electrostatic tactile display with a projected capacitive touchscreen integrated into a single panel was demonstrated. Every electrode on the panel is driven for both tactile presentation and the touch sensor. The functions are both time and spatially multiplexed, and a reference–node‐driven high‐pass filter in the touch controller filters out the noise from the tactile driving signals.
Characteristics and Mechanism of Styrene Cationic Polymerization in Aqueous Media Initiated by Cumyl Alcohol/B(C6F5)3
Authors: Zhang Jinghan , Wu Yibo , Li Xiaoning , Yang Dan , Zhang Min , Wang Hao , Shang Yuwei , Ren Ping , Mu Xin , Li Shuxin , Guo Wenli 
Published: January 2019

AbstractStyrene cationic polymerizations initiated by cumyl alcohol (CumOH)/B(C6F5)3 are systematically studied in aqueous suspension and emulsion. Theoretical calculations and experimental research suggest that CumOH/B(C6F5)3 has higher initiating activity than H2O/B(C6F5)3. During emulsion polymerization of styrene, molecular weight and polymerization rate decrease with the addition of surfactants. These polymerization processes share the same features. Specifically, all elemental reactions (initiation, propagation, and termination) in aqueous media occur at the droplet interface. End structure analysis indicates that chain transfer reactions to water and a‐proton elimination and chain transfer reactions to monomer occur. The possible mechanism for the styrene cationic polymerization in aqueous media is demonstrated.
Functional analysis of the p.[Arg74Trp;Val201Met;Asp1270Asn]/p.Phe508del CFTR mutation genotype in human native colon
Authors: Schucht Sylvia , Minso Rebecca , Lex Christiane , Reiss Jochen , Stanke Frauke , Tamm Stephanie , van Barneveld Andrea , Tümmler Burkhard 
Published: January 2019

AbstractBackgroundThe impact of complex alleles on CFTR processing and function has yet not been investigated in native human tissue.MethodsIntestinal current measurements (ICM) followed by CFTR immunoblot were performed on rectal biopsies taken from two siblings who are compound heterozygous for the CFTR mutations p.Phe508del and the complex allele p.[Arg74Trp;Val201Met;Asp1270Asn].ResultsNormal and subnormal chloride secretory responses in the ICM were associated with normal and fourfold reduced amounts of the mature glycoform band C CFTR, respectively, consistent with the unequal clinical phenotype of the siblings.ConclusionThe combined use of bioassay and protein analysis is particularly meaningful to resolve the CFTR phenotype of “indeterminate” borderline CFTR genotypes on a case‐to‐case basis.
Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population
Authors: Wang Xue , Cao Xudong , Zhang Wanjiang , Zhang Le , Lu Lijun , Li Xinyue , El‐Ashram Saeed , Wu Jiangdong , Chen Chuangfu 
Published: January 2019

AbstractBackgroundTuberculosis (TB) is the second‐leading cause of death globally. Genetic polymorphisms in human leukocyte antigens (HLA)‐DQB2, HLA‐DPA1, and HLA‐DPB1 may partly explain individual differences in TB susceptibility.MethodsWe performed a hospital‐based case–control study to assess the genetic influence of single‐nucleotide polymorphisms (SNPs) in the HLA (HLA‐DPA, HLA‐DPB, and HLA‐DQB) on the development of TB. There were 248 TB‐infected cases and 340 healthy controls in this study.ResultsThe HLA‐DQB2 rs7453920 genotype GG was applied as the reference group, the GA genotype was related to a considerably magnified risk of TB (GA vs. GG: adjusted OR = 1.547, 95% CI = 1.039–2.304, p = 0.032). Nevertheless, the other two SNPs were not associated with TB risk. Stratified analyses suggested that tobacco was associated with an increased risk of TB in HLA‐DQB2 rs7453920 G>A.ConclusionThese results suggested that the functional HLA‐DQB2 rs7453920 G>A polymorphism may contribute to the genetic susceptibility to TB. Nevertheless, the results were based on a limited sample size, and larger well‐designed studies are expected to confirm these preliminary findings.
Trendbericht Anorganische Chemie: Hauptgruppenelemente
Authors: Hering‐Junghans Christian , Sindlinger Christian 
Published: January 2019

AbstractHauptgruppenelemente: Magnesium aktiviert reversibel kleine Moleküle. Stickstoffaktivierung ist nun auch Hauptgruppenangelegenheit. Aluminium zeigt sein nukleophiles Gesicht. Phosphate eignen sich, um funktionalisierte Phosphane herzustellen, und Anionen können mehr Chlor enthalten als gedacht. Bioanorganische und Koordinationschemie: Einblicke in den Mechanismus von [FeFe]‐Hydrogenasen, Rhenium(III)‐Pinzettenkomplexe spalten N2, und Erdalkalimetalle bilden Carbonylkomplexe, die der 18‐Elektronen‐Regel entsprechen.
Interview mit Helga Rübsamen‐Schaeff: "Konzentrierte, kompromisslose Forschung"
Authors: Remenyi Christian , Zbikowski Frauke 
Published: January 2019

AbstractIhr Arbeitgeber gab die Entwicklung virenhemmender Medikamente auf. Die Chemikerin Helga Rübsamen‐Schaeff hielt daran fest und gründete das Unternehmen Aicuris, Anti‐infective Cures. Nun hat sie den Zukunftspreis des Bundespräsidenten erhalten.
Vorstandssitzung
Authors: Koch Wolfram 
Published: January 2019

AbstractDie zweite Sitzung des Vorstands der Gesellschaft Deutscher Chemiker in Jahr 2018 fand am 16. September in Saarbrücken im Zusammenhang mit der dort stattfindenden 130. Versammlung der Gesellschaft Deutscher Naturforscher und Ärzte (GDNÄ) statt.
Patient satisfaction with the quality of nursing care
Authors: Karaca Anita , Durna Zehra 
Published: January 2019

AbstractAimTo evaluate patients’ satisfaction with the quality of nursing care and examine associated factors.DesignA cross‐sectional, descriptive survey study.MethodsThe sample was composed of 635 patients discharged from a private hospital. Data were collected using “Patient Satisfaction with Nursing Care Quality Questionnaire” with a total of 19 items, and a questionnaire designed to record socio‐demographic characteristics and medical histories between January 1–May 31, 2015.ResultsPatients were more satisfied with the “Concern and Caring by Nurses” and less satisfied with the “Information You Were Given.” Patients (63.9%) described nursing care offered during hospitalization as excellent. Patients who were 18–35 years old, married, college or university graduates, treated at the surgery and obstetrics–gynaecology units, and patients who stated their health as excellent and hospitalized once or at least five times were more satisfied with the nursing care. According to this study, the nurses needed to show greater amount of interest to the information‐giving process.
Optimal control of differential‐algebraic equations from an ordinary differential equation perspective
Authors: Ilchmann Achim , Leben Leslie , Witschel Jonas , Worthmann Karl 
Published: January 2019

SummaryWe study the optimal control problem (OCP) for regular linear differentialalgebraic systems. To this end, we introduce the input index, which allows, on the one hand, to characterize the space of consistent initial values in terms of a Kalman‐like matrix and, on the other hand, the necessary smoothness properties of the control. The latter is essential to make the problem accessible from a numerical point of view. Moreover, we derive an augmented system as the key to analyze the OCP with tools well known from optimal control of ordinary differential equations. The new concepts of the input index and the augmented system provide easily checkable sufficient conditions, which ensure that the stage costs are consistent with the differential‐algebraic system.
Successful treatment of a metastatic hepatocellular malignant neoplasm, not otherwise specified with chemotherapy and liver transplantation
Authors: Seng Michaela S. , Berry Bligh , Karpelowsky Jonathan , Thomas Gordon , Mews Catherine , Stormon Michael , Shun Albert , Cole Catherine 
Published: January 2019

AbstractHepatocellular malignant neoplasm, not otherwise specified (HCN‐NOS) is a provisional entity describing a subset of rare malignant pediatric liver tumors with overlapping features of hepatoblastoma and hepatocellular carcinoma. We present a case illustration of metastatic HCN‐NOS successfully treated with a backbone of hepatoblastoma chemotherapy, pulmonary metastastectomy, and liver transplantation, along with a literature review of the clinical outcomes of HCN.
TLC‐bioautography identification and GC‐MS analysis of antimicrobial and antioxidant active compounds in Musa × paradisiaca L. fruit pulp essential oil
Authors: Fahim Mohd. , Ibrahim Mohammad , Zahiruddin Sultan , Parveen Rabea , Khan Washim , Ahmad Sayeed , Shrivastava Birendra , Shrivastava A.K. 
Published: January 2019

AbstractIntroductionThe absence of microbial growth and resistance to oxidative deterioration in fruits of Musa × paradisiaca L. (bananas) is an indication of the presence of antimicrobial and antioxidant metabolites.ObjectiveIn order to investigate the secondary metabolomic spectrum as well as the active antimicrobial and antioxidants present in essential oils (EOs) from fruits of different geographical areas of M. × paradisiaca, gas chromatography‐mass spectroscopy (GC‐MS) principal component data correlation analysis is complemented with antimicrobial assays and phytochemical and bioautographic antioxidant fingerprints with thin layer chromatography (TLC).MethodologyAn EO was obtained by steam distillation and subjected to GC‐MS and TLC for metabolomic profiling from fruit pulp. The antimicrobial potential was tested in both Escherichia coli as a gram negative and Bacillus subtilis as a gram positive microbe. Potential antioxidant metabolites were identified through TLC‐bioautography and GC‐MS analysis of active zones.ResultsA maximum of 0.56% v/w EO was isolated from fruit pulps of M. × paradisiaca. Minimum inhibitory concentrations (MICs) against B. subtillis and E. coli were 0.25 and 0.35 μg/mL, respectively. Thus, 56 metabolites were identified through GC‐MS. The major abundant antimicrobial metabolites found in EOs are α‐thujene, γ‐terpinene, α‐ and β‐pinene, sabinene, β‐myrcene, limonene, α‐capaene, caryophyllene and (Z,E)‐α farnesene. Aceteugenol, palmitic acid, stearic acid, palmitin, and stearin were identified as antioxidant metabolites. Principal component analysis of metabolite data reveals correlations and a clear separation based on metabolites obtained from various areas.ConclusionThe data generated using metabolic profiling and cluster analysis helped to identify antimicrobial and antioxidant compounds in M. × paradisiaca.