bluuebunny/crossref_metadata_2025_split huggingface dataset:
The financial accelerator and marketable debt: the prolongation channel
Authors: Kühl Michael 
Published: October 2018

Abstract
This paper investigates the effects of mark-to-market accounting for risky liabilities on the business cycle. While marking assets to market results in an amplification of the business cycle, as is well-known from the financial accelerator model à la Bernanke, Gertler, and Gilchrist [Bernanke, B. S., M. Gertler, and S. Gilchrist. 1999. “The Financial Accelerator in a Quantitative Business Cycle Framework.” In Handbook of Macroeconomics, edited by J. Taylor and M. Woodford, Elsevier.], allowing for debt with a specific maturity priced at market value generates ambiguous effects. Changes in the market price of debt affects firms’ net worth since the accounting principle takes the perspective of repurchasing debt. This is called the prolongation channel of debt. Real economic activity is attenuated as long as asset and debt prices move in the same direction, whereas the response of debt prices is stronger. This happens for a monetary policy shock or a shock to total factor productivity. Amplification occurs if both prices move in opposite directions, as is the case for a demand shock. The implications for the business cycle eventually depend on the occurrence of shocks. Implementing mark-to-market accounting for liabilities in a model for the US yields a higher volatility of the business cycle.
Space of images of the mixed Riesz hyperbolic B-potential and analytic continuation
Authors: Polovinkin Igor , Shishkina Elina , Sitnik Sergei 
Published: October 2018

Abstract
In this paper we prove semigroup properties for the mixed Riesz hyperbolic B-potential, find its analytic continuation and describe a space of images of mixed hyperbolic Riesz B-potentials.
This problem is closely related to the problem of inversion of the weighted Radon transform on Lorentzian manifolds.
Severe hyperchylomicronemia in two infants with novel APOC2 gene mutation
Authors: Kose Engin , Armagan Coskun , Teke Kısa Pelin , Onay Huseyin , Arslan Nur 
Published: October 2018

AbstractBackgroundFamilial apo C-II deficiency is a rare hereditary disorder frequently caused by lipoprotein lipase (LPL) andAPOC2gene mutations. To date, less than 30 patients with familial apo C-II deficiency with 24 different mutations have been identified in the literature. Here, we describe two familial chylomicronemia syndrome cases in infants with two novel mutations of theAPOC2gene.Case presentationCase 1, a 46-day-old female, was admitted to our hospital for evaluation due to the lipemic appearance of the blood sample. A clinical examination revealed hepatomegaly and lipemia retinalis. Triglyceride level of 6295 mg/dL was decreased with a strict low-fat diet, medium-chain triglycerides (MCT) oil-rich formula and omega-3 fatty acid supplementation. Due to low adherence to the diet, TG elevation was detected and fresh frozen plasma (10 mL/kg/day) was administered for 2 days. A novel homozygous p.Q25X (c.73C>T) mutation in theAPOC2gene was detected. Case 2, a 10-month-old female patient, referred to our center for the differential diagnosis of hyperlipidemia as her blood sample could not be assessed due to its lipemic appearance. Laboratory examinations showed a TG level of 4520 mg/dL which was reduced with a low-fat diet, MCT oil-rich formula and omega-3 fatty acid supplementation. Hepatosteatosis and splenomegaly were determined using abdominal sonography. A novel homozygous IVS2+6T>G (c.55+6T>G) mutation in theAPOC2gene was identified.ConclusionsWe describe two novel homozygous mutations (p.Q25X [c.73C>T] and IVS2+6T>G [c.55+6T>G]) in theAPOC2gene in infants with hyperchylomicronemia. To the best of our knowledge, Case 1 is the youngest patient with familial apo C-II deficiency in the literature to date.
Repetitions in Reserve and Rate of Perceived Exertion Increase the Prediction Capabilities of the Load-Velocity Relationship
Authors: Balsalobre-Fernández Carlos , Muñoz-López Mario , Marchante David , García-Ramos Amador 
Published: October 2018

Abstract
Balsalobre-Fernández, C, Muñoz-López, M, Marchante, D, and García-Ramos, A. Repetitions in reserve and rate of perceived exertion increase the prediction capabilities of the load-velocity relationship. J Strength Cond Res 35(3): 724–730, 2021—This study aimed to (a) analyze the relationships between relative load (i.e., %1 repetition maximum; 1RM) and movement velocity, repetitions in reserve (RIR) and rate of perceived exertion (RPE) in competitive powerlifters and (b) examine whether a multiple linear regression model with the movement velocity, RIR, and RPE as predictor variables could improve the goodness of fit of the load-velocity relationship. Ten competitive powerlifters performed an incremental loading test (from 50 to 100% 1RM) on the full-squat, hip-thrust, and bench press exercises. Barbell velocity was measured using a linear position transducer, while RIR and RPE were registered immediately after each set. Velocity (r
2: 0.747–0.887), RIR (r
2: 0.857–0.928), and RPE (r
2: 0.908–0.933) were moderately to highly related to relative load. A higher amount of variance of the relative load was explained when the RIR and RPE were added to velocity in a multiple regression model in comparison with the load-velocity relationship (r
2: 0.924–0.947). Moreover, it was observed that, in all cases, individual load-velocity, load-RIR, and load-RPE relationships had higher r
2 scores than the generalized load-velocity relationship. Incorporating the RIR and RPE as predictors of the relative load along with movement velocity into a multiple linear regression was shown to provide better estimations of the %1RM than using a linear load-velocity relationship.
Shortened IV Antibiotic Course for Uncomplicated, Late-Onset Group B Streptococcal Bacteremia
Authors: Coon Eric R. , Srivastava Raj , Stoddard Greg , Wilkes Jacob , Pavia Andrew T. , Shah Samir S. 
Published: October 2018

BACKGROUND:
Guidelines recommend a prolonged course (10 days) of intravenous (IV) antibiotic therapy for infants with uncomplicated, late-onset group B Streptococcus (GBS) bacteremia. Our objective was to determine the frequency with which shorter IV antibiotic courses are used and to compare rates of GBS disease recurrence between prolonged and shortened IV antibiotic courses.

METHODS:
We performed a multicenter retrospective cohort study of infants aged 7 days to 4 months who were admitted to children’s hospitals in the Pediatric Health Information System database from 2000 to 2015 with GBS bacteremia. The exposure was shortened IV antibiotic therapy, defined as discharge from the index GBS visit after a length of stay of ≤8 days without a peripherally inserted central catheter charge. The primary outcome was readmission for GBS bacteremia, meningitis, or osteomyelitis in the first year of life. Outcomes were analyzed by using propensity-adjusted, inverse probability–weighted regression models.

RESULTS:
Of 775 infants who were diagnosed with uncomplicated, late-onset GBS bacteremia, 612 (79%) received a prolonged IV course of antibiotic therapy, and 163 (21%) received a shortened course. Rates of treatment with shortened IV courses varied by hospital (range: 0%–67%; SD: 20%). Three patients (1.8%) in the shortened IV duration group experienced GBS recurrence, compared with 14 patients (2.3%) in the prolonged IV duration group (adjusted absolute risk difference: −0.2%; 95% confidence interval: −3.0% to 2.5%).

CONCLUSIONS:
Shortened IV antibiotic courses are prescribed among infants with uncomplicated, late-onset GBS bacteremia, with low rates of disease recurrence and treatment failure.
Forecasting the orbital-climate diagram dynamics based on the wavelet analysis and fuzzy neural networks
Authors: Alekseev Valery I. 
Published: October 2018

Based on the new concept of the V. Bolshakov's orbital theory of paleoclimate, as well as the multiscale time-series wavelet decomposition method, and neural network fuzzy inference rules, the paper derives a predicted curve for the so-called orbital-climate diagram (OCD) in the ratio of (eccentricity, orbit inclination, precession) within the time interval from -1000 kyr in the past to 100 kyr in the future since modern times. This diagram features the Earth climate change caused by an insolation change to be the principal factor of the climate change, driven by Earth's orbital elements changes. Efficiency of the time-series forecast method is proved by the obtained predicted OCD trajectory verification within the past 100 kyr period and other paleoclimate data with a correlation coefficient 0.93.
Modern Russian family: the diagnostics of the decisions using the theory of games
Authors: Ayvarova Natalya S. 
Published: October 2018

Annotation: This article includes the main directions of family development in modern Russia. The purpose of the study is to justify the need for government support for the family. The subject of the study are the decisions of the modern Russian family regarding the taking of mortgages and the birth of children.
To achieve the goal, the following tasks were set: to consider the main decisions taken by the modern Russian family, depending on the family income, using game theory to analyze these decisions and interpreting the results. The main methods for conducting the study were analysis, formalization, induction, etc.
The result of the work is the identification of a number of causes of low fertility in most Russian families, as well as the identification of the main directions of assistance to the family institution on the part of the state.
FormantPro as a Tool for Speech Analysis and Segmentation / FormantPro como uma ferramenta para a análise e segmentação da fala
Authors: Xu Yi , Gao Hong 
Published: October 2018

Abstract: This paper introduces FormantPro, a Praat-based tool for large-scale, systematic analysis of formant movements, especially for experimental data. The program generates a rich set of output metrics, including continuous contours like time-normalized formant trajectories and formant velocity profiles suitable for direct graphical comparisons, and discrete measurements suitable for statistical analysis. It also allows users to generate mean trajectories and discrete measurements averaged across repetitions and speakers. As an illustration of its usage, data from a preliminary study of syllable segmentation in Mandarin were presented. The alignment of continuous formant trajectories enabled by FormantPro provides evidence that the temporal scopes of consonants and vowels are very different from those based on conventional views, and that acoustic and articulatory boundaries of segments are fundamentally similar.Keywords: FormantPro; formant trajectories; syllable segmentation.Resumo: Este artigo apresenta o FormantPro, uma ferramenta que roda no Praat, dedicada à análise sistemática e em larga escala dos movimentos de formantes, especialmente para dados de natureza experimental. O programa gera um rico conjunto de métricas de saída, incluindo contornos contínuos, como as trajetórias de formantes normalizadas temporalmente e perfis de velocidade de formantes adequados para comparações gráficas diretas, bem como medidas discretas adequadas para a análise estatística. O programa também permite aos usuários gerar médias de trajetórias e medidas discretas calculadas a partir das médias de repetições e de falantes. Como ilustração da sua usabilidade, dados preliminares de um estudo sobre segmentação silábica em mandarim foram apresentados. O alinhamento de trajetórias contínuas de formantes geradas pelo FormantPro oferecem evidência de que os escopos temporais de consoantes e vogais são muito diferentes daqueles baseados em visões convencionais, e de que as fronteiras acústicas e articulatórias dos segmentos são fundamentalmente semelhantes.Palavras-chave: FormantPro; trajetórias dos formantes; segmentação silábica
Modelo de gestión de la energía eléctrica con base en indicadores (MGEI), para empresas generadoras con sistemas de cogeneración en Nicaragua
Authors: Blanco-Orozco Napoleón Vicente 
Published: October 2018

En este artículo se propone un modelo de gestión integral de la energía eléctrica con base en indicadores, con las siglas MGEI. La propuesta de modelo se sustenta en la teoría fundamentada por el soporte de herramientas informáticas Atlas ti 7 y SPSS 23 y la consulta a expertos y a un grupo focal. El MGEI se estructura en etapas: la primera etapa es dela toma de decisiones por parte de la gerencia de la empresa; la segunda etapa es la revisión energética, que incluye indicadores de gestión energética; la tercera etapa es la implementación de medidas de ahorro de energía, y la cuarta etapa es la evaluación de las medidas de ahorro de energía implementadas, el monitoreo de los indicadores durante la aplicación de estas medidas, y la comparación entre la línea base energética y los mismos indicadores.
Desarrollo de un sistema de cultivo in vitro de raíces pilosas de Phyllantus acumminatus, para la producción de compuestos con actividad biológica
Authors: Garro-Monge Giovanni , Jiménez-Quesada Karol , Pérez-Méndez Raquel 
Published: October 2018

Las plantas del género Phyllanthus son actualmente investigadas por su habilidad para producir compuestos fenólicos con alta capacidad antioxidante. Además, diversos estudios han revelado que estas plantas poseen metabolitos (filantósidos y lignanos) que pueden inducir la apoptosis celular, lo que les proporciona un gran potencial para posibles tratamientos de prevención contra el cáncer. En este trabajo, se llevó a cabo la introducción in vitro de semillas de P. acumminatus; se logró el cultivo in vitro del material vegetal, y las vitro-plantas fueron utilizadas en ensayos de inducción de raíces pilosas, mediante transformación genética con Agrobacterium rhizogenes cepa Ar15834. El tratamiento más favorable para la inducción de estos cultivos organogénicos consistió en el uso de estacas de aproximadamente 1-2 cm, a las cuales se les hicieron cortes transversales con un bisturí, para luego ser inoculadas en el cultivo bacteriano (OD600: 0.6-1). Las estacas fueron colocadas en medio M & S semisólido al 50% de sales y vitaminas, sin reguladores de crecimiento, por un período de 48 h. Transcurrido este tiempo, las estacas fueron micropropagadas en medio M & S al 100% de sales y vitaminas, complementado con 500 µg/l del antibiótico Ceftriaxona® para erradicar la bacteria. Se logró el cultivo de las raíces pilosas en medio M & S al 100% de sales y vitaminas, sin reguladores de crecimiento. Por medio del uso de microscopía de luz, se logró la caracterización morfológica de las raíces establecidas, las cuales coinciden plenamente con las típicas raíces pilosas o hairy roots obtenidas por medio del sistema de agro-infección, según la literatura consultada.
Completion and Stimulation Design of the First Offshore Acid Fractured Multistage Dual Lateral Well
Authors: Oberhofer R.. , Hoffmann S.. , Norris M. R. , Airnes J.. , Bramald J. A. 
Published: October 2018

Abstract
A North Sea case study detailing the completion and stimulation design of the world's first offshore acid fractured multistage dual lateral will be presented.
The key driver behind this subsea completion technology and stimulation program was to implement a cost effective completion solution that reduced field development costs. The completion technology selected provided an economically viable and low-risk solution in an economically challenging hydrocarbon environment. The completion design was developed to access two separate carbonate gas reservoirs from a single main bore. The stimulation program for the two horizontal laterals was modeled using reservoir characteristics and key considerations. The stimulation program maximized resource efficiency by utilizing the fluid capacities available within one sailing of the stimulation vessel per lateral, totaling 28 acid fracture treatments.
This novel offshore acid fractured dual lateral was drilled, completed and stimulated within three months. The horizontal section of the motherbore was completed using a 14 stage openhole multistage completion solution in three days. To reduce time on location, the well was stimulated after reaching setting depth via a tie-back fracture string. The motherbore was stimulated with individual and distributed acid fracture treatment via sequential ball-activated sliding sleeves. Once operations were complete for the motherbore, a whipstock packer was set and the second horizontal wellbore (Leg 2) drilled. The E1 Leg 2 wellbore was completed in only two days using the same technology and setup as the motherbore. Once the bottomhole completion was set, Leg 2 was stimulated with 14 stages of acid fracture treatments, using the same sized ball-activated sliding sleeves as in the motherbore.
By implementing a flexible low cost completion solution and maximizing the resources available during stimulation, the world's first offshore acid fracture multistage dual lateral was successfully completed, requiring only one subsea wellhead and tree. The completion and stimulation program of this dual lateral project provided a high value solution to North Sea operations by minimizing time, resource utilization and expanding experience for future ventures.
Simulation, Design and Application of Acid+Proppant Stimulation in a Carbonate Reservoir
Authors: Smith Michael B , Deng Jia Yao , Sajid Bilal , Mokhtar Ahmed Anwar , Taramov Musa 
Published: October 2018

Abstract
The application of acid fracturing techniques to deeply buried carbonate reservoirs is often an attractive option due to acid's ability to penetrate/improve natural fracture production where a gel frac fluid may damage the natural fractures. However, effectiveness of acid can be limited due to depth, temperature, and high in situ stress. The introduction of acid creates surface roughness or asperities that hold the fracture open under reservoir conditions, but all three factors above diminish the applicability of acid etched fractures. Under extreme stress these fractures close unless artificially propped open in some fashion. The advantage of combining the two approaches (acid+proppant) is not only an improvement in the natural fracture conductivity through the acid etching, but also yields a longer lasting conductivity in the main fracture from the emplacement of the proppant.
The idea of adding proppant to an acid fracture stimulation job has a long history but has seldom been used due to a fear (not unfounded) of proppant flowback, and the lack of design tools to quantitatively identify proper candidates. Additionally, models based upon the classic Nierode-Kruk correlations were often over-optimistic in predicting fracture conductivity under high stress conditions, disguising the potential need for combination treatments.
Recent developments in modeling, especially the upscaling of laboratory data to field-scale, make it possible to evaluate the combination of both techniques. The completion design and post-test analysis of two recent acid+proppant stimulation programs in Middle-East carbonate reservoirs is examined. Case 1 was a 10m interval at a depth of 3600m (11,800 ft). Closure stress was 700 bar (10,000 psi). Case 2 was a 35 m thick interval at a depth of 2200 m (7000 ft) with an average porosity of 20% and permeability of &gt; 5 mD as determined from wireline logs. Reservoir temperature/pressure for this case were 120 C (260 F) and 250 bar (3600 psi), with an in-situ closure stress of 350 bar (5100 psi). The formation was characterized by the homogeneous distribution of porosity/permeability.
Optimizing Drawdown Strategies in Wells Producing from Complex Fracture Networks
Authors: Kumar Ashish , Seth Puneet , Shrivastava Kaustubh , Sharma Mukul M. 
Published: October 2018

Abstract
In unconventional reservoirs, the presence of natural fractures coupled with high pore pressures leads to the creation of complex fracture networks. During drawdown, the fracture network experiences large changes in the stresses which can affect the fracture conductivity, and hence the production rate. We present a workflow to find an optimum drawdown strategy in which the fractures can remain conductive while maintaining a high enough drawdown to maximize production.
A fully coupled geomechanical reservoir simulator is developed to simulate production from complex fracture networks. Flow in the fracture and reservoir domains is solved in two separate conforming meshes which are coupled through matrix-fracture transfer indices. The complex fracture network is represented as an explicit discontinuity in the reservoir domain which is essential to capture the stress variations in the vicinity of the fractures due to reservoir depletion and fracture closure. The fracture closure process is modeled dynamically using the Barton-Bandis contact relationship, and the fracture conductivity is determined using the fracture width and proppant concentration. This model is used to study the impact of drawdown strategy on fracture conductivity and well productivity.
It is observed that the estimated ultimate recovery (EUR) from complex fracture networks depends upon the connected fracture conductivity and the applied drawdown. A conservative drawdown strategy maintains the fracture conductivity for a longer period but results in a lower initial production rate. As the drawdown is increased, the unpropped fractures close and can cause a large portion of the fracture network (the part behind the closed segment) to get disconnected from the wellbore. This reduces the available fracture area for production. Although an aggressive drawdown strategy results in higher initial production rates, it can lead to faster fracture closure, in turn resulting in a lower EUR. Impact of drawdown strategy on productivity is analyzed at different fracture closure rates.
We show that the optimum choke management strategy depends on the sensitivity of the fracture conductivity to stress. A coupled geomechanical reservoir model is presented that can simulate production with dynamic fracture closure in complex fracture networks to quantify this effect.