bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Ultra-High-Pressure Liquid Chromatographic Tandem Mass Spectrometry Method for the Analysis of Benzoyl Ester Derivatized Glycols and Glycerol.
Authors: Nanco Carrol R , Poklis Justin L , Hiler Marzena M , Breland Alison B , Eissenberg Thomas , Wolf Carl E 
Published: August 2019

AbstractPresented is an ultra-high-pressure liquid chromatographic tandem mass spectrometry (UPLC–MS/MS) method developed for the detection of propylene glycol, glycerol, ethylene glycol and diethylene glycol using isotopically labeled standards in urine as part of ongoing studies to evaluate whether urinary propylene glycol and/or vegetable glycerin concentration are indicators of recent use. Propylene glycol and vegetable glycerol are found in many products that are consumed and used including electronic cigarettes (e-cigarettes). E-cigarettes are battery-powered devices used as an alternative to traditional cigarettes. The liquid formulations aerosolized in these devices largely consist of propylene glycol and/or vegetable glycerol. Published reports regarding the ratio of propylene glycol to glycerol content in these formulations ranged from 50:50 to 100 percent of either. For the analysis of urine specimens from both users and non-users of e-cigarettes, calibrators, controls and specimens were derivatized using benzoyl chloride prior to analysis. They were analyzed using a Waters AcQuity Xevo TQ-S Micro UPLC–MS/MS. Chromatographic separation was performed on an AcQuity UPLC BEH C18 1.7 um, 2.1 × 50 mm, column using a 20 mM ammonium formate in water and 20 mM ammonium formate in methanol as the mobile phase. The method was validated using SWGTOX guidelines for linearity, precision and accuracy, stability, carryover and limit of detection. The linear range was determined using a seven-point calibration curve ranging between 0.5 and 100 mcg/mL. The bias for all validation controls was determined to be ±20% of the expected concentrations with CVs of &lt;15%. A total of 124 urine specimens analyzed collected with 50 specimens collected from self-reported non-smokers (cigarettes/e-cigarettes) confirmed cotinine free using the DRI® Cotinine Assay (Thermo Scientific, Waltham, MA) and 74 specimens collected before and after 12 hours self-reported e-cigarettes abstinence e-cigarette users. Propylene glycol and glycerol were determined to have concentration ranges of “none detected” to 1470 and “none detected” to 2950 mcg/mL, respectively.
Differences in proportional claw size among left- and right-handed Atlantic sand fiddler crabs Leptuca pugilator (Bosc, 1801) (Decapoda: Brachyura: Ocypodidae)
Authors: Martin Benjamin E 
Published: August 2019

AbstractThe sexually dimorphic, enlarged major claw is a prominent feature among fiddler crabs and acts as both a sexual signal and weapon. Most often the enlarged claw occurs on the left and right sides of fiddler crabs in relatively even proportions (40–60%), but populations exhibit an extreme right handedness bias (> 90%) in a few cases. The mechanisms maintaining relatively even handedness proportions among fiddler crabs remains debatable, but from an evolutionary perspective it should be maintained through an evenness in fitness (reproduction and survival) between left- and right-handed crabs. I investigated handedness ratios and claw to body size in a Leptuca pugilator (Bosc, 1801) population on Sapelo Island, Georgia, USA. In collecting 417 adult male crabs, there was a slight right-hand bias (54%, χ 2= 2.9376, P = 0.087), which was similar to the previous study of this population 17 years prior. I nevertheless found right-handed crabs had significantly smaller claw size relative to their carapace size (P = 0.018). Overall, this study documents inequality in the body proportions between left- and right-handed L. pugilator within a population operating at a slight right hand-bias. I discuss how my study contributes to previous discussions on handedness bias in fiddler crabs as well as potential mechanisms that control its widespread handedness evenness.
Cuticular Permeability, Percent Body Water Loss, and Relative Humidity Equilibria Comparisons of Four Termite Species
Authors: Zukowski John , Su Nan-Yao 
Published: August 2019

AbstractThis study compared percentage of total body water (%TBW), water loss rate under desiccative conditions, and cuticular permeability (CP) of four termite species (Order: Blattodea, Infraorder: Isoptera) from different habitats, including one subterranean termite, Coptotermes formosanus Shiraki (Blattodea: Rhinotermitidae), one dampwood termite, Neotermes jouteli (Banks) (Blattodea: Kalotermitidae), one ‘wetwood’ termite, Cryptotermes cavifrons Banks (Blattodea: Kalotermitidae), and one drywood termite, Cryptotermes brevis Walker (Blattodea: Kalotermitidae). There was no consistent pattern associated with the habitat relative humidity (RH) levels and the %TBW among the four termite species tested. Because C. formosanus forage for food, its lowest %TBW may be due to its ability to access water sources, and its need to be more mobile than kalotermitids that remain in wood. Body water loss rate and CP were lower for xeric species such as Cr. brevis than hydric species such as N. jouteli. An RH equilibrium represents the capacity of termite water retention mechanisms that may include the physical structure of cuticular layers, behavioral manipulation of natural openings, and physiological means. As with water loss rate and CP data, RH equilibria were lower for xeric species such as Cr. brevis than hydric species such as N. jouteli. Moreover, RH equilibria for dead individuals of the four termite species were significantly higher than those of live individuals, indicating dead termites lost more water after losing their physiological and behavioral means of retaining water. RH equilibria represent termites’ capability in water retention, and there is a strong linear relationship between RH equilibria and CP values. Hence, RH equilibria may offer simpler alternatives to CP estimates.
Stomach nematodes of cotton rats: parasites, commensals, or mutualists?
Authors: Bergstrom Bradley J , Rose Robert K , Bellows A Scott 
Published: August 2019

Abstract
We related presence and burden of stomach nematodes to body mass and reproductive allocation in hispid cotton rats (Sigmodon hispidus) from two long-running field studies in Virginia (1983–1984, n = 286; and 1988–1990, n = 425) and one from Georgia 1987–1989 (n = 459). Eighty percent of rats from the earlier Virginia sample were infected, with mean nematode mass of 1,311 mg. In the later samples, 23% (Virginia) and 33% (Georgia) were infected with mean nematode mass of 493 and 769 mg, respectively. Presence of nematodes was positively correlated with host body length for each sex in each sample. We used analysis of covariance to examine length-adjusted residuals for presence of nematodes and mass of nematodes for association with somatic and reproductive response variables. Both body and reproductive masses were either positively associated or not related to nematode presence in the two low-prevalence samples, and either negatively associated or not related to nematode presence in the high-prevalence sample. No relationships were detected between host mass and nematode mass per host in either sex in any sample. There was no effect of nematode presence on litter size of pregnant females, but there was a positive effect of nematode mass on litter size in Georgia. Recent theory provides several possible explanations for such neutral-to-positive effects of stomach nematodes on host fitness, including the evolution of host tolerance to the parasites, fecundity compensation by the hosts, and positive effects on host health via immune modulation.
Is Myotis lavali (Chiroptera, Vespertilionidae) endemic to the South American dry diagonal?
Authors: Weber Marcelo M , Novaes Roberto Leonan M , Delgado-Jaramillo Mariana , Barbier Eder , Cláudio Vinícius C , Bernard Enrico , Moratelli Ricardo 
Published: August 2019

AbstractMyotis lavali was described from the M. nigricans complex based on museum specimens from the Caatinga of northeastern Brazil. Current records of the species from about 10 localities suggest that M. lavali seems to occur throughout the South American dry corridor, with peripheral records in the Atlantic Forest. Based on new distribution records, we assess if M. lavali is endemic to the South American dry diagonal corridor through species distribution modeling using an ensemble approach. We obtained 35 occurrences for the species and built a consensus scenario based on 12 algorithms to model its distribution. Even using different thresholds to assign presence and absence of M. lavali, 95–99% of its predicted distribution is within the dry corridor, with few areas in the boundary of the Atlantic Forest, especially in deciduous forests. Therefore, our results support that M. lavali is indeed very likely restricted to the dry diagonal and, although it occupies forested areas, the core of its distribution lies in the Caatinga and in the Cerrado regions of Brazil.
Accuracy of Risk Estimates from the iPrevent Breast Cancer Risk Assessment and Management Tool
Authors: Phillips Kelly-Anne , Liao Yuyan , Milne Roger L , MacInnis Robert J , Collins Ian M , Buchsbaum Richard , Weideman Prue C , Bickerstaffe Adrian , Nesci Stephanie , Chung Wendy K , Southey Melissa C , Knight Julia A , Whittemore Alice S , Dite Gillian S , Goldgar David , Giles Graham G , Glendon Gord , Cuzick Jack , Antoniou Antonis C , Andrulis Irene L , John Esther M , Daly Mary B , Buys Saundra S , Hopper John L , Terry Mary Beth ,   for the kConFab Investigators
Published: August 2019

Abstract

Background
iPrevent is an online breast cancer (BC) risk management decision support tool. It uses an internal switching algorithm, based on a woman’s risk factor data, to estimate her absolute BC risk using either the International Breast Cancer Intervention Study (IBIS) version 7.02, or Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm version 3 models, and then provides tailored risk management information. This study assessed the accuracy of the 10-year risk estimates using prospective data.

Methods
iPrevent-assigned 10-year invasive BC risk was calculated for 15 732 women aged 20–70 years and without BC at recruitment to the Prospective Family Study Cohort. Calibration, the ratio of the expected (E) number of BCs to the observed (O) number and discriminatory accuracy were assessed.

Results
During the 10 years of follow-up, 619 women (3.9%) developed BC compared with 702 expected (E/O = 1.13; 95% confidence interval [CI] =1.05 to 1.23). For women younger than 50 years, 50 years and older, and BRCA1/2-mutation carriers and noncarriers, E/O was 1.04 (95% CI = 0.93 to 1.16), 1.24 (95% CI = 1.11 to 1.39), 1.13 (95% CI = 0.96 to 1.34), and 1.13 (95% CI = 1.04 to 1.24), respectively. The C-statistic was 0.70 (95% CI = 0.68 to 0.73) overall and 0.74 (95% CI = 0.71 to 0.77), 0.63 (95% CI = 0.59 to 0.66), 0.59 (95% CI = 0.53 to 0.64), and 0.65 (95% CI = 0.63 to 0.68), respectively, for the subgroups above. Applying the newer IBIS version 8.0b in the iPrevent switching algorithm improved calibration overall (E/O = 1.06, 95% CI = 0.98 to 1.15) and in all subgroups, without changing discriminatory accuracy.

Conclusions
For 10-year BC risk, iPrevent had good discriminatory accuracy overall and was well calibrated for women aged younger than 50 years. Calibration may be improved in the future by incorporating IBIS version 8.0b.
‘Perfect Vision’: An Examination of the Role of Census and Profiling Practices in Visualizing and Crafting Refugee ‘Groups’ under Contemporary Group-resettlement Programmes
Authors: Batarseh Robert Christian 
Published: August 2019

AbstractThis article demonstrates how the characteristically visual practices of boundary-making around prospective refugee groups comprise an important and instrumentalized version of what Rogers Brubaker (2004) calls ‘groupism’—the assumption that ‘discrete, sharply differentiated, internally homogeneous and externally bounded groups’ are the ‘basic constituents of social life’ (2004: 8). Unlike individual resettlement, group-resettlement schemes (known as ‘Group Processing’ in Canada, ‘Priority-2 group referrals’ in the United States and the ‘Group Methodology’ at the United Nations High Commissioner for Refugees (UNHCR)) involve the resettlement of entire refugee groups. Preoccupations with security and the possibility of identity fraud in these programmes have led to a preference for what are perceived as easily identifiable, finite and homogenous refugee groups. Census and profiling practices permit authorities to visualize and draw boundaries around these types of groups. These practices are the preconditions for the writing of specific narratives of risk, persecution and flight in UNHCR group profiles. An examination of group resettlement reveals how officials do not just choose between pre-existing refugee groups based on racial, national and ethnic categories, but rather attempt to construct an idealized conception of groups reflected in Brubaker’s notion of groupism.
The novel fungal CYP51 inhibitor VT-1598 displays classic dose-dependent antifungal activity in murine models of invasive aspergillosis
Authors: Garvey E P , Sharp A D , Warn P A , Yates C M , Atari M , Thomas S , Schotzinger R J 
Published: August 2019

AbstractAspergillus spp. infections remain a global concern, with ∼30% attributable mortality of invasive aspergillosis (IA). VT-1598 is a novel fungal CYP51 inhibitor designed for exquisite selectivity versus human CYP enzymes to achieve a maximal therapeutic index and therefore maximal antifungal efficacy. Previously, its broad-spectrum in vitro antifungal activity was reported. We report here the pharmacokinetics (PK) and pharmacodynamics (PD) of VT-1598 in neutropenic mouse models of IA. The plasma area-under-the-curve (AUC) of VT-1598 increased nearly linearly between 5 and 40 mg/kg after 5 days of QD administration (155 and 1033 μg*h/ml, respectively), with a further increase with 40 mg/kg BID dosing (1354 μg*h/ml). When A. fumigatus isolates with in vitro susceptibilities of 0.25 and 1.0 μg/ml were used in a disseminated IA model, VT-1598 treatment produced no decrease in kidney fungal burden at QD 10 mg/kg, intermediate decreases at QD 20 mg/kg and maximum or near maximum decreases at 40 mg/kg QD and BID. The PK/PD relationships of AUCfree/MIC for 1-log killing for the two strains were 5.1 and 1.6 h, respectively, similar to values reported for approved CYP51 inhibitors. In a survival study where animals were observed for 12 days after the last treatment, survival was 100% at the doses tested (20 and 40 mg/kg QD), and fungal burden remained suppressed even though drug wash-out was complete. Similar dose-dependent reductions in lung fungal burden were observed in a pulmonary model of IA. These data strongly support further exploration of VT-1598 for the treatment of this lethal mold infection.
A study of stellar orbit fractions: simulated IllustrisTNG galaxies compared to CALIFA observations
Authors: Xu Dandan , Zhu Ling , Grand Robert , Springel Volker , Mao Shude , van de Ven Glenn , Lu Shengdong , Wang Yougang , Pillepich Annalisa , Genel Shy , Nelson Dylan , Rodriguez-Gomez Vicente , Pakmor Rüdiger , Weinberger Rainer , Marinacci Federico , Vogelsberger Mark , Torrey Paul , Naiman Jill , Hernquist Lars 
Published: August 2019

ABSTRACT
Motivated by the recently discovered kinematic ‘Hubble sequence’ shown by the stellar orbit-circularity distribution of 260 CALIFA galaxies, we make use of a comparable galaxy sample at z = 0 with a stellar mass range of $M_{*}/\mathrm{M}_{\odot }\in [10^{9.7},\, 10^{11.4}]$ selected from the IllustrisTNG simulation and study their stellar orbit compositions in relation to a number of other fundamental galaxy properties. We find that the TNG100 simulation broadly reproduces the observed fractions of different orbital components and their stellar mass dependences. In particular, the mean mass dependences of the luminosity fractions for the kinematically warm and hot orbits are well reproduced within model uncertainties of the observed galaxies. The simulation also largely reproduces the observed peak and trough features at $M_{*}\approx 1\rm {-}2\times 10^{10}\, \mathrm{M}_{\odot }$ in the mean distributions of the cold- and hot-orbit fractions, respectively, indicating fewer cooler orbits and more hotter orbits in both more- and less-massive galaxies beyond such a mass range. Several marginal disagreements are seen between the simulation and observations: the average cold-orbit (counter-rotating) fractions of the simulated galaxies below (above) $M_{*}\approx 6\times 10^{10}\, \mathrm{M}_{\odot }$ are systematically higher than the observational data by $\lesssim 10{{\ \rm per\ cent}}$ (absolute orbital fraction); the simulation also seems to produce more scatter for the cold-orbit fraction and less so for the non-cold orbits at any given galaxy mass. Possible causes that stem from the adopted heating mechanisms are discussed.
Monte Carlo simulations of polarimetric and light variability from corotating interaction regions in hot stellar winds
Authors: Carlos-Leblanc Danny , St-Louis Nicole , Bjorkman Jon E , Ignace Richard 
Published: August 2019

ABSTRACT
We use a 3D Monte Carlo radiative transfer code to study the polarimetric and photometric variability from stationary corotating interaction regions (CIR) in the wind of massive stars. Our CIRs are approximated by Archimedean spirals of higher (or lower) density formed in a spherical wind originating from the star and we also made allowance for a bright Gaussian spot at the base of the CIR. Comparing results from our code to previous analytical calculations in the optically thin case, we find differences which we attribute mainly to a better estimation of the total unpolarized flux reaching the observer. In the optically thick case, the differences with the analytical calculations are much larger, as multiple scattering introduces additional complexities including occultation effects. The addition of a Gaussian spot does not alter the shape of the polarization curve significantly but does create a small excess in polarization. On the other hand, the effect can be larger on the light curve and can become dominant over the resulting CIR, depending on the spot parameters and density of the wind.
Deep late-time observations of the supernova impostors SN 1954J and SN 1961V
Authors: Patton Rachel A , Kochanek C S , Adams S M 
Published: August 2019

ABSTRACT
SN 1954J in NGC 2403 and SN 1961V in NGC 1058 were two luminous transients whose definitive classification as either non-terminal eruptions or supernovae remains elusive. A critical question is whether a surviving star can be significantly obscured by dust formed from material ejected during the transient. We use three lines of argument to show that the candidate surviving stars are not significantly optically extinct (τ ≲ 1) by dust formed in the transients. First, we use SED fits to new HST optical and near-IR photometry. Secondly, neither source is becoming brighter as required by absorption from an expanding shell of ejected material. Thirdly, the ejecta masses implied by the Hα luminosities are too low to produce significant dust absorption. The latter two arguments hold independent of the dust properties. The Hα fluxes should also be declining with time as t−3, and this seems not to be observed. As a result, it seems unlikely that recently formed dust can be responsible for the present faintness of the sources compared to their progenitors, although this can be verified with the James Webb Space Telescope. This leaves three possibilities: (1) the survivors were misidentified; (2) they are intrinsically less luminous; (3) SN 1954J and SN 1961V were true supernovae.
XMM-Newton observations of the symbiotic recurrent nova T CrB: evolution of X-ray emission during the active phase
Authors: Zhekov Svetozar A , Tomov Toma V 
Published: August 2019

ABSTRACT
We present an analysis of the XMM-Newton observations of the symbiotic recurrent nova T CrB, obtained during its active phase which started in 2014–2015. The XMM-Newton spectra of T CrB have two prominent components: a soft one (0.2–0.6 keV), well represented by blackbody emission, and a heavily absorbed hard component (2–10 keV), well matched by optically-thin plasma emission with high temperature (kT ≈ 8 keV). The XMM-Newton observations reveal evolution of the X-ray emission from T CrB in its active phase. Namely, the soft component in its spectrum is decreasing with time, while the opposite is true for the hard component. Comparison with data obtained in the quiescent phase shows that the soft component is typical only for the active phase, while the hard component is present in both phases but it is considerably stronger in the quiescent phase. Presence of stochastic variability (flickering) on time-scales of minutes and hours is confirmed both in X-rays and UV (UVM2 filter of the XMM-Newton optical monitor). On the other hand, periodic variability of 6000–6500 s is found for the first time in the soft X-ray emission (0.2–0.6 keV) from T CrB. We associate this periodic variability with the rotational period of the white dwarf in this symbiotic binary.
Physical modelling of galaxy cluster Sunyaev–Zel’dovich data using Einasto dark matter profiles
Authors: Javid Kamran , Perrott Yvette C , Rumsey Clare , Saunders Richard D E 
Published: August 2019

ABSTRACT
We derive a model for Sunyaev–Zel’dovich data from a galaxy cluster that uses an Einasto profile to model the cluster’s dark matter component. This model is similar to the physical models for clusters previously used by the Arcminute Microkelvin Imager (AMI) consortium, which model the dark matter using a Navarro–Frenk–White (NFW) profile, but the Einasto profile provides an extra degree of freedom. We thus present a comparison between two physical models which differ only in the way they model dark matter: one which uses an NFW profile (PM I) and one that uses an Einasto profile (PM II). We illustrate the differences between the models by plotting physical properties of clusters as a function of cluster radius. We generate AMI simulations of clusters that are created and analysed with both models. From this we find that for 14 of the 16 simulations, the Bayesian evidence gives no preference to either of the models according to the Jeffreys scale, and for the other two simulations, weak preference in favour of the correct model. However, for the mass estimates obtained from the analyses, the values were within 1σ of the input values for 14 out of 16 of the clusters when using the correct model, but only in 6 out of 16 cases when the incorrect model was used to analyse the data. Finally, we apply the models to real data from cluster A611 obtained with AMI, and find the mass estimates to be consistent with one another except in the case of when PM II is applied using an extreme value for the Einasto shape parameter.