bluuebunny/crossref_metadata_2025_split huggingface dataset:
HPV Prevalence and its Association with Perinatal Outcomes among Singleton Mothers: Analysis of Pregnancy Risk Assessment and Monitoring System (PRAMS) Data, 2004-2011
Authors: Kaur Harpriya , Schmidt-Grimminger Delf , Chen Baojiang , Islam K.M. Monirul , Remmenga Steven W. , High Robin , Watanabe-Galloway Shinobu 
Published: May 2018

Background:
Pregnancy may increase the risk of Human Papillomavirus (HPV) infection
because of pregnancy induced immune suppression. The objective of this study was to use a
large population-based dataset to estimate the prevalence of HPV infection and its association with
adverse outcomes among pregnant women.

Methods:
We analyzed Pregnancy Risk Monitoring System data from 2004-2011 (N=26,085)
to estimate the self-reported HPV infection. Survey logistic procedures were used to examine the
relationship between HPV infection and adverse perinatal outcomes.

Results:
Approximately 1.4% of women were estimated to have HPV infection during their pregnancy.
The prevalence of adverse outcomes in this sample was preterm birth (8.4%), preeclampsia
(7.5%), low birth weight (6.3%) and premature rupture of membranes (2.8%). Compared to women
without HPV infection, HPV infection positive women were much more likely to have had other
infections such as chlamydia (9.23% vs. 2.12%, p-value <.0001), Group B Strep (21.7% vs.
10.04%, p-value <.0001), and herpes (7.17% vs. 1.07%, p-value <.0001). After adjusting for other
risk factors including other infections, HPV infection was significantly associated with low birth
weight (OR: 1.94, 95% CI: 1.14-3.30).

Conclusion:
The study indicated a potential association between HPV infection and low birth
weight. Because pregnant women with HPV infection are at higher risk of other infections, future
research may focus on the roles of co-infection in the development of adverse perinatal effects.
Antileishmanial Activity of Diterpene lactones from Suregada multiflora and Their Semisynthetic Derivatives
Authors: Gondal Humaira Y. , Nisar Muhammad , Choudhary Muhammad I. 
Published: May 2018

Background:
There is a general lack of effective and economical chemotherapeutic agents
for the treatment of widely prevalent leishmanias. To develop locally available, low cost alternative
therapy, a series of diterpene lactones isolated from Suregada multiflora and their semisynthetic derivatives
have been evaluated against the protozoan parasite Leishmania.

Methods:
A series of diterpene lactones were isolated from methanolic extract of Suregada multiflora.
Major constituents were further derivatized through chemical and microbial transformations. Antileishmanial
activity of structurally diverse diterpene lactones was performed by testing them in vitro
against L. donovani promastigotes. All compounds were also tested for their cytotoxic effects by the
brine shrimp bioassay.

Results:
Among all compounds evaluated in current studies, natural diterpenes Gelomulide A (1) and G
(2) were found significantly active with IC50 values below 20µg/ml. While, among synthesized derivatives;
compounds 5, 9 and 10 were found more potent with IC50 value 17.49, 18.38 and 17.81µg/ml,
respectively. None of these compounds showed cytotoxic effects in the brine shrimp bioassay (LC50>
300).

Conclusion:
A new class of diterpene lactones was identified as potential antileshmanial agent. The
structural diversity of natural and semisynthetic diterpene lactones, helped to rationalize structure–
activity relationships. Activity of these diterpene lactones owed to C-8/14 epoxide along with unsubstituted
C-1. Keto group at C-1 always lower the activity unless it is in α, β-unsaturated form. Presence
of acetyl group at C-3 and 6 usually augmented the antileishmanila potential
Tagging Fatty Acids Via Choline Coupling for the Detection of Carboxylic Acid Metabolites in Biological Samples
Authors: Abualhasan Murad N. , Watson David G. 
Published: May 2018

Background:
Fatty acids and other metabolites containing a carboxyl group are of high interest
in biomedicine because of their major role in many metabolic pathways and, particularly in the
case of oxidised fatty acids, their high biological activity. Tagging carboxylic acid compounds with a
permanent positive charge such as a quaternary ammonium compound could increase the LC-MS detection
sensitivity and selectivity. This paper describes a new and novel strategy for analysing carboxylcontaining
compounds in biological samples by ESI-MS through coupling to choline.

Methods:
Coupling of carboxylic acid derivatives in biological samples was performed by coupling to
2-Fluoro-1, 3 dimethyl –pyridinium (FDMP). The variation in the fatty acid profile of five different
plasma samples was studied and was illustrated by using principal components analysis (PCA) to group
the samples. Orthogonal partial least squares discriminant analysis (OPLS-DA) modelling was then
applied to identify the fatty acids that were responsible for the variation.

Results:
The test results showed that choline coupling reactions were successful in detecting fatty acids,
oxidised fatty acids and other compounds containing carboxylic acid groups in biological samples. The
PCA results showed loadings of different fatty acids according to the plasma sample allowing identification
of the fatty acids responsible for the observed variation.

Conclusion:
A new and easy tagging method was developed to detect carboxylic acids in plasma samples.
The method proved to be precise and reproducible and can quantify fatty acid compounds to 50
ng/ml.
Rationality Evaluation of Packaging Materials and Study on Impurity Profiling of Cilnidipine Preparations by HPLC-Q-TOF/MS
Authors: Zeng Hongxia , Wang Jian , Zhu Bingqi , Shao Peng , Zhong Weihui 
Published: May 2018

Background:
The rationality of cilnidipine tablets and capsules with four different pharmaceutical
packaging materials was evaluated, and the structure of photodegradation impurities was analyzed
by LC-Q-TOF.

Materials and Methods:
The impurity profiling of commercial cilnidipine tablets and capsules was
analyzed by LC-Q-TOF for the further improvement of official monograph in pharmacopoeias and the
source of the impurities was investigated. The contents of photodegradation impurities were analyzed
by HPLC, and remarkable difference in the formation of the photodegradation impurities in cilnidipine
tablets and capsules with four different pharmaceutical packaging materials was observed. The shading
effect of the four packaging materials was investigated by UV-Vis spectrophotometer and a remarkable
difference was detected, which might be responsible for the difference in the formation of photodegradation
products. The structures of photodegradation products were further characterized by LC-Q-TOF
MS/MS. Five impurities in commercial cilnidipine tablets and capsules were separated and identified
based on the high resolution MS/MS data.

Results:
The obtained results revealed that the impurity III was derived from the ethanol solution of
cilnidipine when it was exposed to light, and the impurity II was produced when the cilnidipine powder
was exposed to light directly. The concentrations for 50% reduction of impurity II and impurity III on
the Chinese hamster lung cells (CHL) with CellTiter-Glo method were studied and the results indicated
that the cytotoxicity of impurity II and impurity III on CHL cells was larger than cytotoxicity of cilnidipine.

Conclusion:
On the basis of our study, we suggested that the pharmaceutical packaging materials of
cilnidipine tablets should be modified.
Targeting Negative Regulators of TRIF-dependent TLR Signaling Pathway as a Novel Therapeutic Strategy
Authors: Mosaddeghi P. , Nezafat N. , Negahdaripour M. , Eslami M. , Ghasemi Y. 
Published: May 2018

Background:
Toll-Like Receptors (TLRs) are a subclass of pathogen-associated molecular
patterns (PAMPs). There is a growing interest in the use of TLR agonists for various
pathological dysfunctions, including cancer, microbial infections, and inflammatory diseases.
TLR3/4 agonists that can induce TIR-domain-containing adapter-inducing interferon-β (TRIF)-
dependent pathway have shown fewer toxic immunostimulatory responses in comparison to other
small molecules. Furthermore, TLR3 agonists indicate promising anti-tumor potential in cancer
immunotherapy either as vaccine adjuvant or monotherapy.
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Objective: It is logical to assume that the induction of the genes that are involved in TRIF pathway
to augment their pleiotropic effects on different cells via TLR agonists, could enhance the treatment
process of disease while minimizing the toxicity related to using other small molecules.

Methods:
An extensive literature search to identify the negative regulators of TRIF-dependent
signaling pathway and their biological functions was performed from two databases PubMed and
Scopus.

Results:
Negative regulators of TRIF signaling pathways were identified. In addition, structure
and function of sterile α- and armadillo-motif containing protein (SARM), the only TIR domaincontaining
adaptor protein that inhibits TRIF-dependent activation, were briefly reviewed.

Conclusion:
We proposed that the manipulation of TRIF signaling pathway via targeting its negative
regulators could be used as an approach to modulate the functions of this pathway without
undesired toxic proinflammatory responses.
A novel 4-sensor fast-response aerodynamic probe for non-isotropic turbulence measurement in turbomachinery flows
Authors: Chasoglou Alexandros C. , Mansour Michel , Kalfas Anestis I. , Abhari Reza S. 
Published: May 2018

AbstractIn modern computational studies for turbomachinery applications, time, length scales and isotropy of turbulent structures are important for representative modelling. To this end, experimental data are essential to validate the numerical tools. The current article presents the development and application of a newly designed 4-sensor Fast Response Aerodynamic Probe (FRAP-4S) enabling time-resolved measurement of the three-dimensional unsteady flow velocity vector in turbomachines. The miniature multi-sensor probe demonstrates a 4 mm probe-tip. In the first part of this article the design, manufacturing and calibration results of the FRAP-4S are presented in detail. To assess the newly developed probe accuracy, comparison against traditional instrumentation developed at the Laboratory for Energy Conversion is also provided. In the second part of this work, measurements are performed at the rotor exit of a one-and-a-half stage, unshrouded and highly-loaded axial turbine configuration. The results showed increased level of unsteadiness and turbulence levels with peak-to-peak fluctuation from 5 to 35%. More importantly, in some regions stream-wise unsteadiness was found to be ten times higher, compared to the cross-wise components, an indication of the high degree of anisotropy.
Gênero e sexualidade: diálogos e inquietações com/da/na educação básica
Authors: Gamalho Nola Patrícia , Epitácio Sara , Rosa Gladis Kunz , Da Silva Ferreira Ewerton 
Published: May 2018

O presente artigo tem por objetivo problematizar as discussões sobre currículo, gênero e sexualidades. Parte-se das atividades do projeto de extensão: "Construções e desconstruções do gênero e sexualidade no currículo: tecendo perspectivas para uma educação multicultural", realizado pela Universidade Federal do Pampa - (UNIPAMPA), campus São Borja, juntamente com as escolas da rede de Educação Básica do município. O desenvolvimento dessas atividades, ocorridas no formato de palestras, rodas de debate e atividades práticas, foram fundamentais para propiciar espaços de diálogo. No município em questão predominam historicamente latifúndios voltados para a pecuária e monoculturas, o que implicou em uma estrutura social fortemente assentada no patriarcado e, desta forma, com ramificações nas organizações sociais, políticas, imaginários e representacionais. Portanto, o objetivo de dialogar e desconstruir imaginários de gênero e sexualidade, além de ser um desafio, é uma necessidade emergente. Assim, o texto discorre sobre o contexto espacial e histórico do município; desenvolve uma discussão conceitual sobre gênero, sexualidade e currículo. Por fim, a partir da análise das atividades desenvolvidas, são tecidas reflexões sobre a identidade docente e práticas pedagógicas. Gênero, sexualidade e educação são temas intrincados e em disputa. Assim, as reflexões aqui expostas inserem-se na luta política e social para a constituição de sociedades que aprendam com as diferenças e diversidades.
La fenomenología de la imagen poética de Gaston Bachelard
Authors: Puelles Romero Luis 
Published: May 2018

RESUMENDespués de los intentos de aplicación del psicoanálisis tanto al ámbito de la racionalidad científica como a las obras literarias llevados a cabo por Bachelard entre filanes de los años treinta y la década de los cuarenta, la aparición en 1957 de la peotique de l'espace inaugura un periodo de alejamiento del método psicoanalítico y de afilicación a la escuela fenomenológica. En las páginas que siguen se ofrecen algunas de las claves de esta última época, la cual supone una fecunda contribución al análisis de la imagen poética. PALABRAS CLAVEBACHELARD-ESTÉTICA-FENOMENOLOGÍA-POSEÍAABSTRACTAfter the attempts to apply psycoannalysis both to scientific rationality and to literaly works made by bachelard betwerrn the end of the thirties and the forties, the publicación in 1957 of his la poethique e l'espace inaugurates a period of retrear from the psycoanalytic method and from the phenomenological school. This paper presents some of the clucs of this latest period, characterezied by a fertile contribution to the anlaysis of the poetic imageKEYWORDSBACHELARD-AESTHETICS-PHENOMENOLOGY-POETRY
Development of Research and Innovation Into the Diversity of Bioresources. Food Security Perspectives
Authors: Stan Simona Nicoleta , Strateanu Amalia Gianina 
Published: May 2018

Abstract
Doctrine, legislation and jurisprudence have importance in defining typologies of biodiversity bioresources. Matters of doctrine mainly concern to philosophy of life and the complexity of practical and theoretical hypostases in the current global geopolitical order. In a globalized world, with a society strained by social disorder, among the risks humanity, food supply has become a source of insecurity, in addition to the decline of the natural resources, leading to an intensification of problems at local, zonal, regional and/or global level. Multidimensionality of the concept of security includes demographic and food security, energy and the environment, not only military and political-military level. All these components also guarantee the sovereignty of any state. Food security is a complex and general problem of humanity that all countries are responsible for. FAO defines food security as "access of all people directly to the food they need" to meet their vital functions and lead a healthy and active life ". The responsibility of the present generation is to ensure the right to food for future population, through an efficient, fair and rational management of the Earth bioresources. They belong to the common heritage of mankind and to face the challenges of the safety and food security ahead, on long-term we need a bioethic, systematic and multidisciplinary approach for the right to adequate available and accessible food.
The Evaluation of the Bean Autochthonous Germoplasma in Korça Region
Authors: Maho Adrian , Mero Gjergji 
Published: May 2018

Abstract
Bean is one of the main legacy crops that play an important role in the planting structure of Korça region. Appreciating the bean as a rich food for man, the ancients have particularly been careful in the past to select and preserve the cultivars that have adapted to the ecological conditions of the country. This is evidenced by the large number of legumes planted or labeled according to the areas or villages where they have spread more. At present, this property poses a potential risk, the phenomenon of "genetic erosion". Farmers in the region use the zoned populations of beans. The study of these populations constitutes a necessity for the preservation of the autochthonous germoplasma of the beans as well as the competitive aspects and their spreading. The study revealed the germoplasma of autochthonous bean populations for the region of Korca.
Medication Errors Caused by Nurses and Physicians in a Swiss Acute Care Community Hospital: Frequency and Correlation to Nurses’ Reported Workload / Von Pflegefachpersonen und Ärzten/-innen verursachte Medikamentenfehler in einem Schweizer Akutspital: Häufigkeit und Korrelation zur Arbeitsbelastung von Pflegefachpersonen
Authors: Rapphold Benjamin David , Metzenthin Petra , Oertle Marc , Küng Kaspar 
Published: May 2018

Abstract

Objectives
This study was carried out in a Swiss acute care community hospital to investigate the frequency, type, causes and potential clinical consequences of medication errors (MEs) caused by nurses and physicians in all stages of a technology-supported medication process, the relationship between the nurses’ workload and the medication administration errors (MAEs) and their reason for workload.

Methods
In this descriptive cross-sectional study, a questionnaire, the adapted Medication Error Self Reporting Tool (A-MESRT), was used to identify MEs in all stages of the medication process and record nurses’ self-perceived workload during medication administration.

Results
A total of 1936 completed A-MESRTs were returned. A total of 751 (38.8%) respondents reported different MEs. The highest number of errors occurred during medication administration (43%), followed by errors during dispensing (34%) and physician ordering errors using a computerised physician order entry (CPOE) system (23%). Of the 768 (100%) handwritten orders, 232 (30.2%) were erroneous. Moreover, the greater the individual nurse’s workload during a shift, the higher was the relative probability of committing an MAE (χ2 = 85.479, df = 1, OR = 2.129, p < 0.001). Furthermore, the three main causes of high or very high workload were revealed: (1) many newly operated patients to monitor; (2) complex multimorbid patients, for example, those with delirium; and (3) patients with complications after surgery.

Conclusion
The A-MESRT showed that the highest rate of MEs caused by nurses and physicians is in the non-technologically supported steps, demonstrating the potential benefits of a technology-supported medication process. Moreover, this study revealed a statistically significant correlation between nurses’ workload and MAEs.
Screening by Social Workers in Medical Patients with Risk of Post-Acute Care Needs: A Stepped Wedge Cluster Randomized Trial / Evaluation eines Screenings durch Sozialarbeiter bei medizinischen Patienten mit einem Risiko für post-akuten Nachsorgebedarf: eine stepped wedge clusterrandomisierte Studie
Authors: Conca Antoinette , Ebrahim Doaa , Noack Sandra , Gabele Angela , Weber Helen , Prins Mehrnaz , Keller Anja , Hari Mariann , Engel Angela , Regez Katharina , Schild Ursula , Schuetz Philipp , Müller Beat , Haubitz Sebastian , Kutz Alexander , Huber Andreas , Faessler Lukas , Schäfer-Keller Petra 
Published: May 2018

Abstract

Background
Elderly patients often need post-acute care after hospital discharge. Involvement of social workers can positively affect the discharge planning process.

Aim
To investigate the effect of screening patients at risk for post-acute care needs by social workers on time with respect to social workers’ notification, length of stay and delays in discharge compared to usual care.

Methods
Cluster randomized stepped wedge trial design for five clusters (wards) and two steps (control to intervention) was used. A total of 400 patients (200 per period) with high risk of post-acute care needs (defined as Post-Acute Care Discharge score, PACD ≥ 7) were included. Social workers performed a screening to decide about self-referral to their services (intervention period), which was compared to a highly structured standard SW notification by physicians and nurses (control period). A Generalized Estimating Equations model adjusted the clustering and baseline differences.

Results
A total of 139 patients were referred to social services (intervention: n = 76; control: n = 63). Time to social workers’ notification was significantly shorter in the intervention period when adjusted for all the differences in baseline (Mdn 1.2 vs 1.7, Beta = -0.73, 95%-CI 1.39 to -0.09). Both the length of stay and the delayed discharge time in nights showed no significant differences (Mdn 10.0 vs 9.1, Beta = -0.12, 95%-CI 0.46 to .22 nights 95%-CI, resp. Mdn 0.0 vs 0.0, Beta = .11, 95%-CI -0.64 to 0.86).

Conclusion
Screening speeded up social workers’ notification but did not accelerate the discharge processes. The screening by social workers might show process improvement in settings with less structured discharge planning.
“I feel I am a human being again” Care and Case Management supporting the self-reliance of older people with multimorbidity living alone: Findings of an interpretive-hermeneutical analysis / „Ich bin wieder ein Mensch geworden” Care und Case Management als Unterstützung der Eigenständigkeit allein lebender, mehrfacherkrankter, älterer Menschen: Ergebnisse einer interpretativ-hermeneutischen Analyse
Authors: Schmidt Stefan , Luderer Christiane 
Published: May 2018

Abstract

Objective
This interpretive-hermeneutical study examined how the possibilities offered by Care and Case Management (CCM) were perceived by older people with multimorbidity living alone with regard to their remaining self-reliant and independent.

Method
Guided interviews were conducted with 20 CCM users (60% women, age range between 64 and 89 years). The sampling and evaluation processes were based on the Grounded Theory method.

Results
Before CCM was initiated, the interviewed persons had been confronted with a multitude of offers and services for care provided by various organizations, which had made it difficult for them to get an overall view. Through CCM they felt strengthened in their everyday life because each individual life situation became the focal point of the care they needed and because they gained access to appropriate assistance, which would not have been possible without CCM.

Conclusions
CCM offers older people content-related and organizational support in various areas of life, thus enabling them to have a self-determined way of life in their own homes.
Effects of miR-99a on the migration and proliferation of glioma cells
Authors: Xu Yifan , Lu Tianyu , Xu Wu , Dai Yuxiang , Liang Weibang , Jin Wei 
Published: May 2018

Abstract
Background To evaluate the effects of miR-99a on the migration and proliferation of glioma cells. Materials and Methods: Glioma cell line LN229 with stable up-regulation of miR-99a was constructed by transfection of hsa-miR-99a mimics, and cells with stable miR-99a knock-down were established by transfection of hsa-miR-99a inhibitor. The proliferation capacities of two groups were detected by the MTT assay, and their migration capacities were detected by the scratch assay. Results: LN229 cells with stable up-regulation and knock-down of miR-99a were successfully constructed. Up-regulating miR-99a inhibited the proliferation and migration of glioma cells, but knocking down this gene promoted their proliferation and migration. Conclusion: MiR-99a significantly affected the proliferation and migration of glioma cells, as a potentially eligible target for glioma therapy.