bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corn grain yield, residue production, and nutrient concentration and extraction is affected by different residue incorporation rates in two biannual crop rotations
Authors: Hirzel Juan , Undurraga Pablo , León Lorenzo , Vera Carola , Matus Iván 
Published: November 2024

Abstract
Conservation practices in agriculture using crop rotations and residue management benefit the productivity; these can vary depending on climate and soil conditions, crops, and amount of incorporated residue. The present study evaluated the effect of two biannual rotations; canola (Brassica napus L.) – corn (Zea mays L.) and bean (Phaseolus vulgaris L.) – corn rotations with four residue incorporation rates (0%, 50%, 100%, and 200%) of the preceding crop on corn grain yield, residue production, and nutrient concentration and extraction after two rotation cycles in a volcanic soil of moderate depth in south-central Chile. Grain yield varied between 17.04 and 17.40 Mg/ha, residue production between 16.41 and 16.50 Mg/ha. The preceding crop affected concentration and extraction of some nutrients in both grain and residue. The residue rate affected both concentration and extraction of some nutrients only in the grain. The Ca distribution to the corn grain was negatively affected by both the preceding bean crop and increasing residue incorporation rate. The ranking of total macronutrient extraction in the corn crop was K > N > Ca > P > Mg > S. The extraction means ranged from 320 to 326, 56.0 to 57.1, 365 to 374, 86.5 to 99.3, 39.4 to 42.4, and 22.6 to 23.7 kg/ha, whereas grain nutrient distribution coefficients ranged from 64.5 to 66.8, 90.1 to 90.9, 23.1 to 23.7, 1.3 to 2.0, 50.8 to 57.5, and 60.3 to 60.6 for N, P, K, Ca, Mg and S, respectively.
Erythropoietin for the prevention of postoperative neurocognitive disorder in older adult patients undergoing total joint arthroplasty: a randomized controlled study
Authors: Kim Eun Jung , Park Kwan Kyu , Choi Su Youn , Ju Hyang Mi , Kim Tae Lim , Kim Jeongmin , Kim Soo Yeon , Koo Bon-Nyeo 
Published: November 2024

Abstract
Background
Post-operative delirium (PD) is a common post-operative complication with significant clinical and financial impacts on patients. Erythropoietin (EPO), a multi-functional glycoprotein hormone, exhibits erythropoietic and non-erythropoietic anti-inflammatory properties. This study aimed to determine the role of perioperative EPO administration in the development of postoperative delirium in older adult patients undergoing total joint arthroplasty.

Methods
Seventy-one patients (> 65 years old) scheduled for total joint arthroplasty were randomly assigned to two groups: EPO-treated (EPO, n = 35) and placebo (control, n = 36). All patients completed the Mini Mental State Examination (MMSE) pre-operatively and on post-operative day (POD) 2. The confusion assessment method (CAM) was used to assess the patients until discharge (POD 5). Serum C-reactive protein (CRP) and inflammatory cytokine levels were measured and compared pre- and post-operatively. The development of delirium and cognitive dysfunction was evaluated post-operatively.

Results
One patient in the control group developed delirium on POD 2 (3.2%), whereas no patient in the EPO group developed PD (0% vs. 3.2%, p = 0.500). Post-operatively there was no significant difference in MMSE scores between groups. Both groups showed increases in pro- and anti-inflammatory cytokine levels, with no significant differences. Similarly, CRP levels, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) showed no intergroup differences in post-operative inflammatory responses.

Conclusions
Perioperative EPO reduced the incidence of post-operative delirium, although not statistically significant, with no differences in post-operative cognitive function and inflammatory responses.

Trial registration
The trial was registered on December 12, 2023 at http//clinicaltrials.gov, registration number NCT06178835.
Facilitating the transition from hospital to home after hip fracture surgery: a qualitative study from the HIP HELPER trial
Authors: Welsh A , Hanson S , Pfeiffer K , Khoury R , Clark A , Grant K , Ashford P-A , Hopewell S , Logan PA , Crotty M , Costa ML , Lamb SE , Smith TO ,   on behalf of the HIP HELPER Study Collaborators, Clifford Penny , Freeman Lis , Gray Rene , Paget James , Cunningham Yan , Langford Sarah , Baxter Mark , Pawson Jessica , Taylor Melissa , Mellows Anna , Lacey Kate , Herring Alex , Williams Diane , Cromie Anna , Menton Gail , Corbett Warren , Jowett Helen , Joshi Vishwanath , Matharu Maninderpal , Baggot Maria , Barker David , Dutton Susan , Sahota Opinder , Sheehan Katie 
Published: November 2024

Abstract
Background
People post-hip fracture have reported experiences of fragmented care and poor discharge planning, therefore improvements in patient flow are required. This study reports the challenges people face during the discharge process and offers potential solutions for improving the transition from hospital to home from the perspectives of patients, carers, and health professionals.

Methods
This was a qualitative study embedded within a multi-centre, feasibility randomised controlled trial (HIP HELPER). We undertook semi-structured interviews with 10 patient-carer dyads (10 people with hip fracture; 10 unpaid carers) and eight health professionals (four physiotherapists, two occupational therapists, one nurse and one physiotherapy researcher) between November 2021 and March 2022. Data were analysed using the principles of Framework Analysis.

Results
Participants identified challenges in the transition from hospital to home post-hip fracture surgery: ineffective communication, disjointed systems, untimely services and ‘it’s more than just the hip’. Possible solutions and insights to facilitate this transition included the need for reassurance, collaborative planning, and individualisation.

Conclusion
The transition from hospital to home following hip fracture surgery can be a challenging experience for patients, and for friends and family who support them as carers, making them feel vulnerable, frustrated and uncertain. Enabling a coordinated, collaborative approach to discharge planning and early recovery provision is considered a positive approach to improving NHS care.

Trial registration
ISRCTN13270387. Registered 29th October 2020.
Factors associated with eating performance in nursing home residents living with dementia and other comorbidities
Authors: Liu Wen , Lee Kyuri , Galik Elizabeth , Resnick Barbara 
Published: November 2024

Abstract
Background
Eating performance is the functional ability to get food into the mouth and chew/swallow it. Nursing home residents with dementia commonly experience compromised eating performance and subsequent consequences. Prior work examined the association between resident eating performance and their cognitive and functional ability. Yet, the associations between resident eating performance and behavioral and psychological symptoms, psychotropic medication use, and comorbidities are less studied. This study aimed to examine the association between eating performance and cognition, functional ability, behavioral and psychological symptoms, psychotropic medication use, and comorbidities in nursing home residents with dementia.

Methods
This was a secondary analysis using baseline data from two randomized controlled trials, testing the impact of Function Focused Care on function and behavioral symptoms in 882 residents with moderate-to-severe dementia (mean age 86.55 years, 71% female, 30% non-white, 68.5% severe dementia) from 67 nursing homes in two states between 2014 and 2020. Eating performance (dependent variable) was measured using the single self-feeding item of Barthel Index. Independent variables included cognitive impairment, functional ability (Barthel Index total score excluding the self-feeding item score), behavioral and psychological symptoms (agitation, depression, resistiveness-to-care), psychotropic medication use (anti-depression, sedative, anti-psychotics, anti-seizure, anti-anxiety), and comorbidities.

Results
Nearly 39% of residents were dependent in eating. On average, residents had five documented comorbidities (SD = 3.06, range = 0–12) and were on approximately one psychotropic medication (SD = 1.25, range = 0–5). Eating performance was associated with cognitive impairment (OR = 0.53, 95% CI = 0.35, 0.79, p = .002), functional ability (OR = 1.05, 95% CI = 1.04, 1.06, p < .001), depressive symptoms (OR = 0.94, 95% CI = 0.89, 0.98, p = .007), and anxiolytic use (OR = 0.64, 95% CI = 0.42, 0.99, p = .046).

Conclusions
Findings supported that better eating performance was associated with less cognitive impairment, higher functional ability, fewer depressive symptoms, and less anxiolytic use. Targeted interventions to accommodate to cognitive function, optimize functional ability, minimize anxiolytic use, and manage depressive symptoms are encouraged to support eating performance in residents with dementia.
Adverse events after nivolumab and ipilimumab combined immunotherapy in advanced renal cell carcinoma: a multicentre experience in Poland
Authors: Pacholczak-Madej Renata , Drobniak Artur , Stokłosa Łukasz , Bidas Anna , Dobrzańska Jolanta , Grela-Wojewoda Aleksandra , Roman Agnieszka , Tusień-Małecka Daria , Walocha Jerzy , Blecharz Paweł , Puskulluoglu Mirosława 
Published: November 2024

Abstract
Background
Immune checkpoint inhibitors (ICIs) have been employed in the adjuvant and metastatic setting of renal cell carcinoma (RCC) treatment. Among ICIs, combined immunotherapy has the highest risk for immune-related adverse events (irAEs). We aimed to document the incidence of irAEs in RCC patients treated with nivolumab and ipilimumab as data from the European population remain limited.

Materials and methods
We analysed data from 88 RCC patients treated with nivolumab + ipilimumab between May 2022 and June 2024 across six high-volume oncology units in Poland. We reviewed irAEs and estimated their impact on survival parameters via univariate and multivariate Cox proportional hazards regression models, along with log-rank tests.

Results
With a median follow-up of 11.3 months, the median overall survival (OS) was not reached, whereas the median progression-free survival (PFS) was 12.8 months (6.3–19.3). A total of 74 irAEs were recorded in 50 patients. The most frequent events were endocrine (n = 20, 27%), hepatic (n = 15, 17%), general (n = 12, 13.6%), and cutaneous (n = 11, 12.5%). The occurrence of irAEs was associated with a 60% lower risk of disease progression (hazard ratio 0.44, 95% confidence interval 0.2–0.87, p = 0.018) without impacting OS and higher disease control rate (n = 45, 90% vs. n = 24, 63.2%, p = 0.004). In contrast, patients with hepatotoxicity had poorer outcomes, with a 2.6-fold greater risk of death (p = 0.05).

Conclusions
IrAEs may serve as a predictive factor for the efficacy of the nivolumab + ipilimumab regimen in RCC patients. Special attention is needed for hepatotoxicity, as it can significantly impact survival outcomes.
Emergency neurosurgery for traumatic brain injury by general surgeons at local hospitals in Sweden: a viable option when time is brain
Authors: Leal-Méndez Francisco , Holmberg Lina , Enblad Per , Lewén Anders , Linder Fredrik , Wettervik Teodor Svedung 
Published: November 2024

Abstract
Background
Timing of surgical evacuation of mass lesions in traumatic brain injury (TBI) is crucial. However, due to geographical variations, transportation time to the nearest neurosurgical department may be long. To save time, general surgeons at a local hospital may perform the operation, despite more limited experience in neurosurgical techniques. This study aimed to determine whether patient outcomes differed between those who had undergone emergency neurosurgery at local hospitals by general surgeons vs. at university hospitals by neurosurgeons.

Methods
A nationwide observational study was performed using data from the Swedish Trauma Registry (SweTrau) between 2018 and 2022. A total of 565 TBI patients (local hospitals, n = 21; university hospitals, n = 544) who underwent intracranial hematoma evacuation within 8 h after arrival at the hospital were included. Data on demography, admission variables, traumatic injuries, and outcome (Glasgow Outcome Scale [GOS]) at discharge were evaluated. Favourable vs. unfavourable outcomes were defined as GOS scores of 4–5 vs. 1–3.

Results
Compared with those treated at university hospitals, patients treated with intracranial hematoma evacuation at local hospitals had lower median Glasgow Coma Scale (GCS) scores (8 vs. 12, p < 0.001), higher rate of acute subdural hematomas (86% vs. 77%, p < 0.001), and lower rate of contusions (14% vs. 53%, p = 0.01). Being operated on at a local hospital was independently associated with higher mortality (p = 0.03) but with a similar rate of favourable outcome (p = 0.74) in multiple logistic regressions after adjustment for demographic and injury-related variables.

Conclusions
Although a slightly greater proportion of patients who underwent emergency neurosurgery at local hospitals died, there was no difference in the rate of favourable outcome. Thus, in patients with impending brain herniation, when time is of the essence, evacuation of traumatic intracranial bleeding by general surgeons at local hospitals remains a highly viable option.
Zoonotic Dirofilaria sp. “hongkongensis” in subcutaneous nodules from dogs and cats, Hong Kong SAR
Authors: Manathunga Thamali , Tse May , Perles Livia , Beugnet Frederic , Barrs Vanessa , Otranto Domenico 
Published: November 2024

Abstract
Background
Dirofilaria sp. “hongkongensis” is a putative Dirofilaria species, initially identified in subcutaneous nodules in humans in Hong Kong and in other South and Southeast Asian regions. While it differs genetically from the better-known zoonotic species, Dirofilaria repens and Dirofilaria immitis, information on the lesions caused by Dirofilaria sp. “hongkongensis” in the hosts as well as on its biology is scarce. This study documents for the first time the presence of this filarioid nematode in subcutaneous nodules in dogs and cats in Hong Kong, where it was originally described in human patients, therefore providing evidence for the zoonotic nature of this parasite.

Methods
Records of Veterinary Diagnostic Laboratory of City University of Hong Kong were searched between 2019 and 2024 for histological reports of possible filarioid-associated lesions. Tissue samples were collected by excisional surgical biopsy and processed with routine paraffin techniques. Selected slides were stained using various staining techniques [i.e., hematoxylin and eosin, periodic acid–Schiff (PAS), Grocott methenamine silver (GMS) or Ziehl–Neelsen (ZN) and Gram stain]. DNA from formalin-fixed paraffin-embedded tissue were extracted, submitted to conventional polymerase chain reaction (cPCR) and sequencing (i.e., cox1 and 12S rRNA genes) and phylogenetic analyzed.

Results
A total of five subcutaneous nodules from four cats and one from a dog with histopathology suggestive of filariosis were selected. The presence of Dirofilaria sp. “hongkongensis” was morphologically and molecularly confirmed in one dog and one cat. Both histopathological presentation and phylogenetic analysis enabled classification of this species close to D. repens and within the subgenus Nochtiella. In the remaining three cases, one showed histological evidence of aberrant nematode migration, while non-parasitic causes were identified in the other two.

Conclusions
This study provides the first evidence of Dirofilaria sp. “hongkongensis” in subcutaneous nodules in cats and dogs. The histology of clinical lesions of this filarioid species herein described is closely related to those caused by D. repens. Overall, this species should be considered in differential diagnoses of subcutaneous lesions in both animals and humans in the region.

Graphical Abstract
Predictive value of contrast-enhanced MRI for the regrowth of residual uterine fibroids after high-intensity focused ultrasound treatment
Authors: Liu Yang , Xiao Zhibo , Luo Yuanli , Qiu Xueke , Wang Lu , Deng Jinghe , Yang Mengchu , Lv Fajin 
Published: November 2024

Abstract
Objectives
To investigate whether the signal intensity (SI) ratio of residual fibroid (RF) to myometrium using Contrast-Enhanced Magnetic Resonance Imaging (CE-MRI) could predict fibroid regrowth after high-intensity focused ultrasound (HIFU) treatment.

Materials and methods
A retrospective analysis was conducted among 164 patients with uterine fibroids who underwent HIFU. To predict the RF regrowth, the SI perfusion parameters were quantified using the RF-myometrium SI ratio on CE-MRI on day 1 post-HIFU and then compared with the fibroid-myometrium SI ratio on the T2-weighted image (T2WI) and Funaki classification 1 year later. Thirty cases from another center were used as an external validation set to evaluate the performance of RF-myometrium SI ratio.

Results
The predictive performance of the RF-myometrium SI ratio on CE-MRI on day 1 post-HIFU (Area Under Curve, AUC: 0.869) was superior to that of the preoperative and postoperative fibroid-myometrium SI ratios on the T2WI (AUC: 0.724, 0.696) and Funaki classification (AUC: 0.663, 0.623). Multivariate analysis showed that the RF- myometrium SI ratio and RF thickness were independent factors. The RF-myometrium SI ratio reflects the long-term rate of re-intervention (r = 0.455, p < 0.001).

Conclusion
The RF-myometrium SI ratio on CE-MRI exhibits greater accuracy in predicting RF regrowth compared to the SI classification and the SI ratio on T2WI.

Critical relevance statement
The ratio of residual uterine fibroid to myometrial signal intensity on contrast-enhanced (CE)-MRI can reflect residual blood supply, predict regrowth of fibroids, and thus reflect long-term re-intervention rate and recovery situation of clinical high-intensity focused ultrasound (HIFU) treatment.

Key Points

Contrast-enhanced (CE)-MRI can indicate the blood supply of residual uterine fibroids after high-intensity focused ultrasound (HIFU) treatment.

The predictive capability of CE-MRI ratio surpasses T2WI ratio and the Funaki.

Residual fibroids can serve as a measure of the long-term efficacy of HIFU.

Graphical Abstract
Constructing and exploring neuroimaging projects: a survey from clinical practice to scientific research
Authors: Chen Ziyan , Adegboro Abraham Ayodeji , Gu Lan , Li Xuejun 
Published: November 2024

Abstract
Over the past decades, numerous large-scale neuroimaging projects that involved the collection and release of multimodal data have been conducted globally. Distinguished initiatives such as the Human Connectome Project, UK Biobank, and Alzheimer’s Disease Neuroimaging Initiative, among others, stand as remarkable international collaborations that have significantly advanced our understanding of the brain. With the advancement of big data technology, changes in healthcare models, and continuous development in biomedical research, various types of large-scale projects are being established and promoted worldwide. For project leaders, there is a need to refer to common principles in project construction and management. Users must also adhere strictly to rules and guidelines, ensuring data safety and privacy protection. Organizations must maintain data integrity, protect individual privacy, and foster stakeholders’ trust. Regular updates to legislation and policies are necessary to keep pace with evolving technologies and emerging data-related challenges.

Critical relevance statement
By reviewing global large-scale neuroimaging projects, we have summarized the standards and norms for establishing and utilizing their data, and provided suggestions and opinions on some ethical issues, aiming to promote higher-quality neuroimaging data development.

Key Points

Global neuroimaging projects are increasingly advancing but still face challenges.

Constructing and utilizing neuroimaging projects should follow set rules and guidelines.

Effective data management and governance should be developed to support neuroimaging projects.

Graphical Abstract
Computed tomography enterography-based deep learning radiomics to predict stratified healing in patients with Crohn’s disease: a multicenter study
Authors: Zhu Chao , Liu Kaicai , Rong Chang , Wang Chuanbin , Zheng Xiaomin , Li Shuai , Wang Shihui , Hu Jing , Li Jianying , Wu Xingwang 
Published: November 2024

Abstract
Objectives
This study developed a deep learning radiomics (DLR) model utilizing baseline computed tomography enterography (CTE) to non-invasively predict stratified healing in Crohn’s disease (CD) patients following infliximab (IFX) treatment.

Methods
The study included 246 CD patients diagnosed at three hospitals. From the first two hospitals, 202 patients were randomly divided into a training cohort (n = 141) and a testing cohort (n = 61) in a 7:3 ratio. The remaining 44 patients from the third hospital served as the validation cohort. Radiomics and deep learning features were extracted from both the active lesion wall and mesenteric adipose tissue. The most valuable features were selected using univariate analysis and least absolute shrinkage and selection operator (LASSO) regression. Multivariate logistic regression was then employed to construct the radiomics, deep learning, and DLR models. Model performance was evaluated using receiver operating characteristic (ROC) curves.

Results
The DLR model achieved an area under the ROC curve (AUC) of 0.948 (95% CI: 0.916–0.980), 0.889 (95% CI: 0.803–0.975), and 0.938 (95% CI: 0.868–1.000) in the training, testing, and validation cohorts, respectively in predicting mucosal healing (MH). Furthermore, the diagnostic performance of DLR model in predicting transmural healing (TH) was 0.856 (95% CI: 0.776–0.935).

Conclusions
We have developed a DLR model based on the radiomics and deep learning features of baseline CTE to predict stratified healing (MH and TH) in CD patients following IFX treatment with high accuracies in both testing and external cohorts.

Critical relevance statement
The deep learning radiomics model developed in our study, along with the nomogram, can intuitively, accurately, and non-invasively predict stratified healing at baseline CT enterography.

Key Points

Early prediction of mucosal and transmural healing in Crohn’s Disease patients is beneficial for treatment planning.

This model demonstrated excellent performance in predicting mucosal healing and had a diagnostic performance in predicting transmural healing of 0.856.

CT enterography images of active lesion walls and mesenteric adipose tissue exhibit an association with stratified healing in Crohn’s disease patients.

Graphical Abstract
Intussusception of the appendix secondary to endometriosis: a case report
Authors: Kawaguchi Yuta , Maekawa Kyoichiro , Hashimoto Toshiaki , Kitagawa Mizuki , Urabe Shigetoshi , Yoshimura Emi , Goto Takashi , Rikitake Mihoko , Iwata Tohru 
Published: November 2024

Abstract
Background
Intussusception of the appendiceal endometriosis is rare. Although approximately 200 cases of appendiceal intussusception have been reported in the literature, very few have ever been diagnosed preoperatively. Here, we report the case of intussusception of the appendiceal endometriosis with laparoscopic ileocecal resection.

Case presentation
A woman in her 50s presented to the out-patients clinic with epigastric pain lasting for a several month. Contrast-enhanced computed tomography (CT) scanning revealed ileocolic intussusception in which a cecum polypoid mass lesion extended to the hepatic flexure of the ascending colon. A colonoscopy showed a large pedunculated polyp in the cecum. Laparoscopic ileocecal resection was performed. Pathology confirmed an invaginated appendix demonstrating endometriosis implants.

Conclusions
Possible intrinsic causes of intussusception are varied, appendiceal intussusception secondary to endometriosis is extremely rare. Intussusception of the appendix is a rare finding, often mistaken for a polyp. We suggest considering inverted appendix as a differential diagnosis when investigating cecal lesions.