bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health‐Related Quality of Life During Carfilzomib–Lenalidomide–Dexamethasone Consolidation: Findings From the Multiple Myeloma CONPET Study
Authors: Rosenberg Tine , Möller Sören , Abildgaard Niels , Nørgaard Jakob Nordberg , Lysén Anna , Tsykonova Galina , Joao Cristina , Vangsted Annette , Schjesvold Fredrik , Nielsen Lene Kongsgaard 
Published: December 2024

ABSTRACTBackgroundIn the CONPET study, multiple myeloma patients with abnormal 18FDG positron emission/computed tomography scan after upfront autologous stem cell transplantation were treated with four cycles of carfilzomib–lenalidomide–dexamethasone (KRd). Side effect registrations show that carfilzomib might cause dyspnea, cough, respiratory tract infections, and heart failure. The aims were to investigate patient‐reported shortness of breath and dyspnea during KRd consolidation.MethodsTo assess shortness of breath, patients completed the Functional Assessment of Cancer Therapy—Pulmonary Symptom Index (FACT‐PSI) and the EORTC QLQ‐C30 to assess dyspnea. Shortness of breath was defined as decrease in FACT‐PSI score or starting/increasing diuretic drugs. Mixed effect logistic regression was used for the effect analysis. Linear mixed model and clinical relevance were used to investigate dyspnea.ResultsA total of 50 patients were included, median age 62 years (interquartile range 54–67). 17% reported shortness of breath at Day 15 Cycles 1–4 versus 11% at Day 1 Cycles 2–4, Cycle 4 Day 29, and 1 month posttreatment (p‐value 0.048). Compared with baseline, patients reported significant, and clinically relevant worsening in dyspnea during consolidation.ConclusionOur study confirmed earlier findings of carfilzomib causing shortness of breath during KRd administration and revealed dyspnea during consolidation compared to baseline.Trial Registration
Clinicaltrials.gov: NCT03314636, EudraCT: 2017–000586‐72
Performance of Warmblood horses following tenoscopic desmotomy of the main part of the accessory ligament of the superficial digital flexor tendon for treatment of tendinopathy: 62 cases
Authors: Blatter Marlis , Chapman Hannah‐Sophie , Heinzel‐Gutenbrunner Monika , von Plato Guido , Rijkenhuizen Astrid 
Published: December 2024

AbstractBackgroundDesmotomy of the accessory ligament of the superficial digital flexor tendon (AL‐SDFT) has been described for the treatment of superficial digital flexor tendon (SDFT) tendinopathy in Thoroughbred and Standardbred racehorses, and in event horses. To our knowledge, the outcome of this procedure has not been described in a population of warmblood horses.ObjectiveTo report on the outcome of treatment of SDFT tendinopathy in warmblood horses using tenoscopic desmotomy of the main part of the AL‐SDFT.Study designProspective observational case series.MethodsAll 62 horses included in the case series had uni‐ or bilateral SDFT tendinopathy within the metacarpal/carpal region. The following data were collected and analysed using crosstabulations: breed, age, sex, use, affected limb(s), duration of tendinopathy, lameness grade, type and size of the SDFT lesion, bi‐ or unilateral desmotomy, duration of surgery, intraoperative findings, intraoperative/post‐operative complications, duration of hospitalisation and outcome 24 months after surgery.ResultsForty‐six horses (75%) were sound with 31 (51%) of these horses performing at the same level as prior to injury. Recurrent SDFT injuries or persistent lameness was observed in 15 (25%) horses. Two horses (3%) developed septic tenosynovitis post‐operatively, one required euthanasia. Horses with lesions in the proximal third of the SDFT had a better outcome than those with lesions in the two distal thirds (OR = 4.71, 95% CI = 1.33–16.70).Main LimitationsThere were no control groups of horses with SDFT tendinopathy treated by conservative therapy, tenoscopic complete or conventional open desmotomy.ConclusionsTenoscopic desmotomy of the main part of the AL‐SDFT is a successful treatment for SDFT tendinopathy in warmblood horses, especially in proximal SDFT lesions.
How much energy can giant reed and Miscanthus produce in marginal lands across Italy? A modelling solution under current and future scenarios
Authors: Cappelli Giovanni Alessandro , Ginaldi Fabrizio , Fanchini Davide , Ceotto Enrico , Donatelli Marcello 
Published: December 2024

AbstractPractical strategies for bioenergy planning in the face of climate change should rely on ready‐to‐use yield projections. Perennial grasses grown in marginal lands (MLs) provide abundant feedstocks to be converted into different energy vectors. The aim of this study was to provide a model‐based assessment of how much energy, in the form of biomethane and bioethanol, can be achieved by Miscanthus and giant reed across Italy. Marginal lands were here conceived as low profitable non‐irrigated areas, without mechanization and/or nature conservation constraints. Marginal lands eligible for simulations were selected crossing environmental factors and ecological requirements of the two crops. The biophysical model Arungro was calibrated considering rainfed/full‐irrigated systems using multiple‐site and multiple‐year datasets. The model was connected to a georeferenced database, with information on (i) current/future climate, (ii) agronomic practices, (iii) soil physics/hydrology, (iv) MLs, and (v) crop suitability to environment and simulations were performed at 500 × 500 m spatial resolution across all Italian regions. Under baseline conditions (i.e., 1981–2010), the total area of MLs available for energy crops (i.e., 49,100 km2) allowed to obtain 23,500 (giant reed) and 23,700 (Miscanthus) Giga‐m3 CH4‐STP of biomethane and 18,600 (giant reed) and 24,400 (Miscanthus) Giga‐liters of bioethanol. While the amount of energy carriers is expected to increase, on average, of +4.6% in 2055 and + 0.4% (mean of +9.2%—South, −2.4%—Center, −5.4%—North Italy) in 2085 for Miscanthus, giant reed‐based productions are projected to be more stable across the country and time frames (+6.7% in 2055; +2.8% in 2085). This study contributed to define a modular and detailed procedure aimed at quantifying attainable energy yields from bioenergy grasses in MLs. The consideration of fine‐resolution multiple‐scale heterogeneity allowed for an in‐depth investigation of biomass productivity, attainable energy yields, and related stability under current/climate change scenarios, highlighting critical spots and opportunities within the country.
Dental Anomalies in the Past: Fusion, Gemination, and Talon Cusp in Two Archeological Samples
Authors: Imposimato Naomi , Mazur Marta , Sperduti Alessandra , De Santis Paola , Lugli Federico 
Published: December 2024

ABSTRACTBackgroundDisruption in odontogenesis can influence the normal development of both deciduous and permanent dentition resulting in anomalies in morphology, number, and position of teeth. Although dental anomalies are frequently reported in clinical practice, their occurrence in past populations from archeological contexts is rarely acknowledged.AimTo describe two cases of dental anomalies on two non‐adult individuals from Italian archeological sites.DesignIndividual sex diagnosis was performed by analyzing amelogenin peptides from the dental enamel through liquid chromatography mass spectrometry (LC–MS/MS). Age‐at‐death estimation was based on stages of dental formation and eruption. Dental twinning and talon cusp were morphologically evaluated and classified following standardized scoring systems proposed by clinical literature.ResultsThe first individual, a 3–4‐year‐old female from the Imperial Roman necropolis of Isola Sacra, presents the fusion of the upper right deciduous central incisor with a supplementary tooth; the second individual, a 3–3.5‐year‐old male from a Late Antiquity catacomb, shows a case of bilateral gemination on the upper permanent central incisors with a co‐occurrence of dental gemination and talon cusp on the right one.ConclusionsThe cases reported here (the two anomalies in the individuals presented) are useful into understanding these dental conditions within past/archaeological populations.
Approaching merchant ships elicit behavioral changes in Atlantic sturgeon (Acipenser oxyrinchus) in the St. Lawrence River, Canada
Authors: Senecal Jean‐Francois , Dupuch Angélique , Lagrois Dominic , Mingelbier Marc , Chion Clément 
Published: December 2024

AbstractThere are gaps in our understanding of sturgeon's response to anthropogenic sounds and the spatial scales at which they occur. We measured spatial displacement of Atlantic sturgeon in the St. Lawrence River at various distances of approaching merchant ships. This fish population is designated as “threatened,” although anthropogenic noise is not currently considered a direct threat. For several years, Atlantic sturgeon migrations have been monitored by the Quebec government using acoustic transmitters and a network of telemetry receivers in the St. Lawrence River. We combined fish telemetry data with merchant ship positions to detect co‐occurrences between Atlantic sturgeons that remained in the vicinity of the receivers and approaching ships. Numerical simulations reveal that the probability of masking of transmitters (69 kHz) by ship noise was infinitesimal and that the disappearance of the transmitter signal was related to fish movement. When the ships approached, a significant spatial displacement was detected with ships at distances between 0.5 and 5 km from the receivers. After emitter signal loss, over 61% of sturgeons took at least 30 min to be detected again or did not return at all in the vicinity of the receivers. Furthermore, the median time to redetection after a ship transit was longer than when no ship was approaching (31 vs. 18 min). Our results show that sturgeons alter their position due to approaching ships at greater trigger distances than previously documented, which are too far away to be attributed to visual cues alone. We also found that the long‐distance propagation of low‐frequency sounds from large ships through water should not be heard by Atlantic sturgeon at distances of 1 km and longer based on current knowledge of sturgeons hearing. These results suggest that behavioral responses in Atlantic sturgeons are modulated not only by visual cues but can also be triggered by underwater sounds at relatively long distances, although the precise mechanism is still unknown.
The influence of sex and age differences in an adult zebrafish (Danio rerio) T‐maze model of cognition
Authors: Yin Ji‐Hang , Horzmann Katharine A. 
Published: December 2024

AbstractThe zebrafish (Danio rerio) model is increasingly popular in neurobehavioral research, and behavioral outcomes are commonly evaluated in studies on neurodegeneration and neurotoxicity. Sex and age have been identified as important variables in cognition studies; however, these factors are often underreported in published studies that use the zebrafish model, leading to uncertainty about their impact in zebrafish T‐maze experiments. In this study, we evaluated the role of sex and age in zebrafish cognitive function using a 5‐day T‐maze task. Our results demonstrated that female and younger zebrafish had increased learning and memory capacity. These findings highlighted the importance of considering and reporting sex and age in experimental design in zebrafish cognitive neurobehavioral studies.
Designing episode of care bundles to improve children's oral health care
Authors: Love Kailey , Harootunian Gevork , Riley William 
Published: December 2024

AbstractObjectivesThere is growing momentum to introduce value‐based payment (VBP) approaches into dentistry to help improve population oral health status. However, there are very few VBP models available for dentistry. This study designs and analyzes the feasibility of introducing oral health episode of care (EOC) bundles for use by policy makers, payers, and dental providers.MethodsAn oral health EOC bundle is a standardized care process based on a set of best practices that has the potential to improve patient care quality when all bundle items are provided. We used a panel of dental experts to guide the design of two preventive EOC bundles for children, a comprehensive examination bundle and a periodic examination bundle. We then conducted a 12‐year retrospective longitudinal analysis to simulate the completion rate of the EOC bundles for children receiving Medicaid benefits in Arizona from 2008 to 2019.ResultsAn average of 805,229 children were enrolled annually in the Arizona Medicaid program across the 12‐year period. Approximately 31% of the Medicaid enrolled children had a preventive dental visit twice a year, and 23% completed two preventive EOC bundles. On average, 126,602 (16%) of patients started the comprehensive examination bundle and 279,194 (35%) of patients started the periodic examination bundle. Overall completion rates for the Comprehensive Examination and Periodic Examination Bundles were 73% and 79% respectively.ConclusionsIt is feasible to design a preventive oral health EOC bundle for children. The findings have implications for developing VBP approaches for oral health care.
Investigating the Factor Structure of the Japanese Version of the Interpersonal Reactivity Index
Authors: Himichi Toshiyuki , Kawamura Yuta , Goto Takayuki 
Published: December 2024

AbstractThe Interpersonal Reactivity Index (IRI) is widely used to measure empathy; however, the factor structure and scoring of the IRI have been inconsistent. Previous studies showed a bifactor model with empathic concern (EC) and perspective taking (PT) as a better model for the Chinese version of the IRI. This study investigated whether this model was better than other candidate models for the Japanese version of the IRI. In Study 1, we compared the model fit parameters of confirmatory factor analysis using datasets from previous studies. The results showed that the bifactor model with EC and PT was the best among 42 models. Study 2 investigated which concepts were extracted in a bifactor model that was derived from web‐based survey data. Results showed that the general factor in the bifactor model might measure the compound characteristics of both EC and PT. Additionally, the extracted EC factor might measure avoidance of harm to others, and the extracted PT factor might reference inferring others' minds. This study suggests that the bifactor model with EC and PT has the best factor structure and that the extracted factors reflect different aspects of empathy.
The fundamental theorem of asset pricing with and without transaction costs
Authors: Kühn Christoph 
Published: December 2024

AbstractWe prove a version of the fundamental theorem of asset pricing (FTAP) in continuous time that is based on the strict no‐arbitrage condition and that is applicable to both frictionless markets and markets with proportional transaction costs. We consider a market with a single risky asset whose ask price process is higher than or equal to its bid price process. Neither the concatenation property of the set of wealth processes, that is used in the proof of the frictionless FTAP, nor some boundedness property of the trading volume of admissible strategies usually argued within models with a nonvanishing bid–ask spread need to be satisfied in our model.
Anionic phospholipid‐mediated transmembrane transport and intracellular membrane trafficking in plant cells
Authors: Zhang Qun , Shen Like , Lin Feng , Liao Qi , Xiao Shi , Zhang Wenhua 
Published: December 2024

SummaryCellular membranes primarily consist of proteins and lipids. These proteins perform cellular functions such as metabolic regulation, environmental and hormonal signal sensing, and nutrient transport. There is increasing experimental evidence that certain lipids, particularly anionic phospholipids, can act as signaling molecules. Specific examples of functional regulation by anionic phospholipids in plant cells have been reported for transporters, channels, and even receptors. By regulating the structure and activity of membrane‐integral proteins, these phospholipids mediate the transport of phytohormones and ions, and elicit physiological responses to developmental and environmental cues. Phospholipids also control membrane protein abundance and lipid composition and abundance by facilitating vesicular trafficking. In this review, we discuss recent research that elucidates the mechanisms by which membrane‐integral transporters and channels are controlled via phospholipid signaling, as well as the regulation of membrane protein accumulation by phospholipids through coordinated removal, recycling, and degradation processes.
The SLR1‐OsMADS23‐D14 module mediates the crosstalk between strigolactone and gibberellin signaling to control rice tillering
Authors: Li Xingxing , Xie Zizhao , Qin Tian , Zhan Chenghang , Jin Liang , Huang Junli 
Published: December 2024

Summary
Strigolactones (SLs) and gibberellins (GAs) have been found to inhibit plant branching or tillering, but molecular mechanisms underlying the interplay between SL and GA signaling to modulate tillering remain elusive.
We found that the transcription factor OsMADS23 plays a crucial role in the crosslink between SL and GA signaling in rice tillering. Loss‐of‐function mutant osmads23 shows normal axillary bud formation but defective bud outgrowth, thus reducing the tiller number in rice, whereas overexpression of OsMADS23 significantly increases tillering by promoting tiller bud outgrowth.
OsMADS23 physically interacts with DELLA protein SLENDER RICE1 (SLR1), and the interaction reciprocally stabilizes each other. Genetic evidence showed that SLR1 is required for OsMADS23 to control rice tillering. OsMADS23 acts as an upstream transcriptional repressor to inhibit the expression of SL receptor gene DWARF14 (D14), and addition of SLR1 further enhances OsMADS23‐mediated transcriptional repression of D14, indicating that D14 is the downstream target gene of OsMADS23–SLR1 complex. Moreover, application of exogenous SL and GA reduces the protein stability of OsMADS23–SLR1 complex and promotes D14 expression.
Our results revealed that SLs and GAs synergistically inhibit rice tillering by destabilizing OsMADS23–SLR1 complex, which provides important insights into the molecular networks of SL–GA synergistic interaction during rice tillering.
New‐Occurrence of Postoperative Modic Changes and Its Influence on the Surgical Prognosis After Percutaneous Endoscopic Lumbar Disc Discectomy
Authors: Li Lei , Wang Chao , Zhang Hao , Liu Zhiming , Lian Zheng , Li Han , Tao Hao , Ma Xuexiao 
Published: December 2024

ABSTRACTObjectivesLumbar disc herniation (LDH) is a common degenerative spinal disease in clinical practice. This study aims to investigate the impact of Modic changes (MCs) on postoperative recovery and disease recurrence following percutaneous endoscopic lumbar disc discectomy (PELD), providing important insights for improving the management of chronic low back pain. This study investigates the 1‐year progression rate of MCs after PELD and their impact on surgical outcomes and recurrence.MethodsThis retrospective cohort study analyzed data from 419 patients with single‐segment lumbar disc herniation who underwent PELD between January 2019 and December 2022. Lumbar MRI assessed preoperative and postoperative MCs. Pain levels and surgical outcomes were evaluated using the visual analog scale, Oswestry Disability Index, and Macnab criteria. Univariate analysis explored the relationship between postoperative MCs and pain, while subgroups investigated the associations between postoperative efficacy, recurrence, and MCs type and area.ResultsOne‐year follow‐up revealed that the probability of MCs postsurgery was 24.8%. Patients with postoperative MCs had significantly lower pain scores compared with the control group (p < 0.05). Univariate analysis indicated that the type and area of postoperative MCs were risk factors for poor outcomes in PELD patients (p < 0.05). During the 1‐year follow‐up, recurrence rates in the no‐MCs and MCs groups were 3.8% and 9.6%, respectively (p < 0.05). Univariate analysis concluded that the area of postoperative MCs was a risk factor for PELD recurrence.ConclusionThe postoperative MCs, as a risk factor, may have a detrimental effect on the surgical efficacy and short‐term recurrence of LDH following PELD based on a large sample. Furthermore, the harmful effect is affected by the area and type of the postoperative MCs.
Proteome Reprogramming and Acquired Stress Tolerance in Potato Cells Exposed to Acute or Stepwise Water Deficit
Authors: Cappetta Elisa , Del Regno Carmine , Ceccacci Sara , Monti Maria Chiara , Spinelli Lucio , Conte Marisa , D'Anna Chiara , Alfieri Mariaevelina , Vietri Mariapia , Costa Antonello , Leone Antonietta , Ambrosone Alfredo 
Published: December 2024

ABSTRACTWater deficit negatively impacts crop productivity and quality. Plants face these challenges by adjusting biological processes and molecular functions according to the intensity and duration of the stress. The cultivated potato (Solanum tuberosum) is considered sensitive to water deficit, thus breeding efforts are needed to enhance its resilience. To capture novel functional information and gene regulatory networks, we carried out mass spectrometry‐based proteomics in potato cell suspensions exposed to abrupt or stepwise osmotic stresses. Both forms of stress triggered significant alterations in protein expression, though with divergent response mechanisms. Stress response pathways orchestrated by key proteins enrolled in primary and secondary metabolism, antioxidant processes, transcriptional and translational machinery and chromatin organization were found in adapted cells. Target metabolites and reactive oxygen species levels were quantified to associate functional outcomes with the proteome study. Remarkably, we also showed that adapted cells tolerate an array of diverse conditions, including anoxia, salt and heat stress. Finally, the expression patterns of genes encoding selected differentially expressed proteins were investigated in potato plants subjected to either drought or salt stress. Collectively, our findings reveal the complex cellular strategies of osmotic stress adaptation, identifying new fundamental genes that could enhance potato resilience.
Equal Opportunity Sensitive Aggregate Wellbeing Measurement: Food Security and Basic Household Income on Sub‐Sahara African Farms
Authors: Anderson Gordon , Manero Ana , Bjornlund Henning 
Published: December 2024

ABSTRACTEquality of Opportunity and gender equality, key components of the UNs' Sustainable Development Goals and Inclusive Growth initiatives, require wellbeing measures that reflect the extent to which such targets are being achieved. From a measurement perspective, the Equal Opportunity literature distinguishes between inequalities arising from individual choice and inequalities engendered by circumstances beyond individual control, only the latter should enter the calculus. However, common metrics of socio‐economic inequality make no such distinction confounding different inequality sources and obfuscating potential intervention pathways. Using recent intertemporal data from family farms on four Zimbabwean and Tanzanian irrigation schemes, this study introduces and exemplifies new methods for measuring Equality of Opportunity multidimensionally within an overall wellbeing framework. Results indicate a deterioration in equality of opportunity in access to land, with an improvement in equality of opportunity in revenue generation, with the former outweighing the latter in a joint analysis resulting in a decline in overall wellbeing.