bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mood, Dimensional Personality, and Suicidality in a Longitudinal Sample of Patients with Bipolar Disorder and Controls
Authors: Kamali Masoud , Saunders Erika F. H. , Assari Shervin , Ryan Kelly A. , Marshall David F. , McInnis Melvin G. 
Published: November 2018

ObjectiveTo evaluate the effects of mood and anxiety symptoms in relation to personality dimensions and clinical features such as trauma and substance use on suicidal behaviors in a longitudinal sample of individuals with bipolar illness (BP) and healthy controls (HC).MethodsMood, personality, and clinical features were assessed in 151 individuals with BP I and 119 HC. Clinical data were collected at baseline and at 2‐year follow‐up. Personality traits were measured using the NEO PI‐R.ResultsIn bivariate analyses, personality measures were significantly different between BP and HC, and between BP based on suicide attempt history. However, in regression analyses, baseline measures of depression, mania, anxiety, trauma, education, and age of BP onset correlated with personality domains, while a history of suicide attempts did not. Logistic regressions showed that prospective depression or mania, and a pattern of mixed mood features and chronicity of illness, along with two Neuroticism facet scores (N4—Self‐Consciousness and N6—Vulnerability) were predictive of suicide ideation (SI) in the 2‐year follow‐up period.ConclusionsWhile dimensions of personality, trauma, and substance use clearly correlated with suicidal behaviors in BP, in multivariate models emerging mood symptoms were the most robust predictors of suicidality. These results reinforce the importance and attributable role of mood and anxiety symptoms in evaluating suicidal risk.
Relationship Status and Suicidal Behavior in Gay Men: The Role of Thwarted Belongingness and Hope
Authors: Riley Kym , McLaren Suzanne 
Published: November 2018

ObjectiveLevels of suicidal behavior among gay men are a significant concern. The Interpersonal Theory of Suicide proposes that being unpartnered is a risk factor for suicidal behavior due to thwarted belongingness; however, this has yet to be tested empirically. Recent studies also indicate that the two components of hope, agency and pathways, may be protective against suicidal behavior. The first aim of the current study was to investigate whether thwarted belongingness mediates the relationship between relationship status and suicidal behavior in gay men. The study also examined whether agency and pathways weaken the association between relationship status and thwarted belongingness, and whether agency weakens the relation between thwarted belongingness and suicidal behavior.MethodA sample of 370 self‐identified gay men aged from 18 to 66 years old (M = 26.13, SD = 8.02) completed the Suicidal Behaviors Questionnaire—Revised, the Interpersonal Needs Questionnaire—Revised, and the Adult Dispositional Hope Scale.ResultsResults showed that thwarted belongingness mediated the relationship between relationship status and suicidal behavior. The hypothesized moderated‐mediation models were not supported.ConclusionsThese findings have implications for the development of interventions that aim to reduce suicidal behaviors in gay men.
Association of sedentary time and physical activity during pregnancy with maternal and neonatal birth outcomes. The GESTAFIT Project
Authors: Baena‐García Laura , Ocón‐Hernández Olga , Acosta‐Manzano Pedro , Coll‐Risco Irene , Borges‐Cosic Milkana , Romero‐Gallardo Lidia , de la Flor‐Alemany Marta , Aparicio Virginia A. 
Published: November 2018

AbstractAim(a) To analyse the association of objectively measured sedentary time (ST) and physical activity (PA) during early second trimester of pregnancy with maternal and neonatal birth outcomes; (b) to explore if ST and PA differ between women with vaginal or caesarean section deliveries.MethodsNinety‐four Caucasian pregnant women (32.9 ± 4.6 years old) participated in this prospective longitudinal study. Triaxial accelerometers were used to assess ST and PA intensity levels for seven consecutive days during second trimester of pregnancy. Birth data were collected from the obstetric medical records. Umbilical cord arterial and venous blood gas (pH, partial pressure of carbon dioxide and oxygen, and oxygen saturation) were analysed after birth.ResultsAfter adjusting for potential confounders, greater ST was associated with higher arterial and venous cord blood partial pressure of carbon dioxide and more acidic arterial and venous pH (all, P < 0.01). Moderate PA, moderate‐to‐vigorous PA (MVPA), total PA and steps per day were positively associated with arterial cord blood oxygen saturation (all P < 0.05). Steps per day were inversely associated with gestational age at birth (P < 0.01), and duration of first stage of labor (P < 0.05). Total and light PA were associated with a more alkaline pH in umbilical vein (all, P < 0.01). Vigorous PA was inversely associated with the Apgar score (P < 0.01). No significant differences were observed in ST and PA levels between women with vaginal and women with caesarean section deliveries (all, P > 0.10).ConclusionIncreasing PA and decreasing ST during pregnancy might promote better maternal and neonatal birth markers.
Are you my attachment figure? A (currently) unanswerable question
Authors: Kammrath Lara K. , Clifton Mona 
Published: November 2018

AbstractThe attachment figure construct is the centerpiece of attachment theory. Research has suggested that most adults have three to five such figures at any given time, many of whom are in normative attachment roles, such as mothers, fathers, and romantic partners, but some of whom are not, such as friends and other family members. An important challenge in attachment research is to identify who a given individual's unique attachment figures are. In this paper, we review the definitional criteria for attachment figures and summarize existing methods to identify idiographic attachment figures. While recognizing the advancements current measures have brought the field, we argue that they oversimplify the challenges in attachment figure identification. We argue that if one uses enacted behavioral data rather than perceived data to measure specific attachment criteria, one quickly encounters unsolvable complexities that preclude attachment figure classifications. This has deep implications for the status of attachment figure construct itself. We outline the implications for current attachment theory and discuss potential paths forward.
A randomized clinical trial comparing Nitrofurazone‐coated and uncoated urinary catheters in kidney transplant recipients: Results from a pilot study
Authors: Menezes Fernando Gatti , Corrêa Luci , Medina‐Pestana Jose Osmar , Aguiar Wilson Ferreira , Camargo Luis Fernando Aranha 
Published: November 2018

AbstractBackgroundUrinary tract infections are frequent complications early after kidney transplantation, and the use of antimicrobial coated catheters in settings other than transplantation has shown promising results for infection prevention. The purpose of this study was to compare the efficacy of Nitrofurazone‐coated silicone urinary catheters with non‐impregnated silicone urinary catheters in reducing bacteriuria and urinary tract infections in kidney transplant recipients.MethodsThis single‐center study, randomized controlled trial at the Hospital do Rim, a tertiary referral center in kidney transplantation, located in São Paulo, Brazil. Subjects involved living donor kidney transplant recipients, and were randomized 1:1 ratio with a computer‐generated system to a Nitrofurazone‐coated silicone urinary catheter and non‐impregnated silicone urinary catheter from March 2013 to December 2014. Patients with asymptomatic bacteriuria or urinary tract infection at baseline, deceased kidney transplant donors, patients with known hypersensitivity to nitrofurantoin, pregnancy, and those refusing to sign the informed consent form were excluded from the study.ResultsTwo hundred fourteen subjects were randomized and one hundred seventy‐six completed the study. There were no differences in the rates of asymptomatic bacteriuria (12.5% in the Nitrofurazone group and 11.4% in the control group, P = 0.99) and urinary tract infection (8% and 6.8%, P = 0.99) and the incidence of side effects was more frequent in the Nitrofurazone‐impregnated silicone urinary catheter group (46.6% and 26.1%, P = 0.007).ConclusionThe study suggests that there is no beneficial effect of the employment of Nitrofurazone‐coated urinary catheter. Trial registration number: ISRCTN57888785.
Safety evaluation of a lyophilized platelet‐derived hemostatic product
Authors: Barroso Jeffrey , Osborne Barbara , Teramura Gayle , Pellham Esther , Fitzpatrick Michael , Biehl Ruth , Yu Anna , Pehta Joan , Slichter Sherrill J. 
Published: November 2018

BACKGROUNDHemorrhage causes significant morbidity and mortality in people aged <65 years. A lyophilized platelet‐derived hemostatic agent (Thrombosomes) demonstrated hemostatic efficacy in animal models. We report the results of the first safety trial of autologous Thrombosomes given to normal subjects.STUDY DESIGN AND METHODSTen subjects received autologous Thrombosomes prepared from their apheresis platelets, and five control subjects received a buffer solution. There were five cohorts, with three subjects per cohort (two in the Thrombosomes group and one in the control group). Doses escalated from 1/1,000 to 1/10 of a proposed efficacious dose. Cohorts 4 and 5 received the highest dose, but in Cohort 5, one‐half the dose was infused 2 hours apart. Cohorts 1 through 3 were monitored for 42 days, Cohorts 4 and 5 were monitored for 60 days using hematology, coagulation, and chemistry assays and antibody testing.RESULTSThere were no serious adverse events (AEs) and no subject withdrawals. There were eight treatment‐related AEs (TRAEs) in 5 of 15 subjects (33%) (four in the Thrombosomes group and one in the control group). Of four subjects receiving the highest doses, three had TRAEs. One had elevated D‐dimer, prothrombin fragment 1 + 2, and white blood cell count (subject had concurrent upper respiratory tract infection); one had T‐wave inversions in precordial leads V2 and V3 without elevated troponin or symptoms; and one had a platelet autoantibody without change in platelet count. All subjects’ TRAEs resolved by Day 21.CONCLUSIONThere were no serious AEs in this small study. Thrombosomes were considered safe at the doses assessed. Future, larger trials will be needed to further assess safety and efficacy.
Comparison of filgrastim, pegfilgrastim, and lipegfilgrastim added to chemotherapy for mobilization of CD34+ cells in non‐Hodgkin lymphoma patients
Authors: Partanen A. , Valtola J. , Ropponen A. , Kuitunen H. , Kuittinen O. , Vasala K. , Ågren L. , Penttilä K. , Keskinen L. , Pyörälä M. , Nousiainen T. , Selander T. , Mäntymaa P. , Pelkonen J. , Varmavuo V. , Jantunen E. 
Published: November 2018

BACKGROUNDData are limited on the long‐acting granulocyte‐colony stimulating factors (G‐CSFs) pegfilgrastim (PEG) and lipegfilgrastim (LIPEG) compared with filgrastim (FIL) regarding the mobilization efficiency of CD34+ cells, graft cellular composition, and engraftment.STUDY DESIGN AND METHODSIn this prospective nonrandomized study, 36 patients with non‐Hodgkin lymphoma received FIL, 67 received PEG, and 16 patients received LIPEG as a cytokine after chemotherapy. We analyzed the mobilization and collection of CD34+ cells, cellular composition of blood grafts, and hematologic recovery after auto‐SCT according to the type of G‐CSF used.RESULTSPatients in the LIPEG group had fewer apheresis sessions (1 vs. 2, p = 0.021 for FIL and p = 0.111 for PEG) as well as higher median blood CD34+ cell counts at the start of the first apheresis (LIPEG 74 × 106/L vs. FIL 31 × 106/L, p = 0.084 or PEG 27 × 106/L, p = 0.021) and CD34+ yields of the first apheresis (FIL 5.1 × 106/kg vs. FIL 2.3 × 106/kg, p = 0.105 or PEG 1.8 × 106/kg, p = 0.012). Also, the costs associated with G‐CSF mobilization and apheresis were lower in the LIPEG group. The graft composition was comparable except for the higher infused CD34+ cell counts in the LIPEG group. The engraftment kinetics were significantly slower in the FIL group.CONCLUSIONLIPEG appears to be more efficient compared with PEG after chemotherapy to mobilize CD34+ cells for auto‐SCT demonstrated as fewer sessions of aphereses needed as well as 2.8‐fold CD34+ cell yields on the first apheresis day. Early hematologic recovery was more rapid in the LIPEG group. Thus further studies on LIPEG in the mobilization setting are warranted.
Modeling rare blood in Canada
Authors: Blake John T. , Clarke Gwen 
Published: November 2018

BACKGROUNDMany countries maintain rare blood programs to provide access to blood for patients with complex serologies. These include a process to screen donors and a registry to record information about rare donors; blood agencies may also freeze some units. However, frozen blood is much more expensive than liquid blood.STUDY DESIGN AND METHODS.A two‐phase approach to analysis was used to evaluate how rare a blood type must be before a frozen inventory is necessary and what screening rates are required to support a rare blood program. A simulation model was employed to evaluate the impact of inventory on patient access.RESULTSResults suggested that, for 27 of 29 phenotypes managed by Canadian Blood Services, insufficient donors had been identified to ensure a stable inventory. Analytic results showed the screening rate necessary to ensure a stable inventory and the time frame to build a rare donor base.Twenty‐nine simulation scenarios were executed to evaluate patient access to rare blood against inventory levels. Results show that some amount of frozen inventory is necessary for phenotypes rarer than 1 in 3000. However, holding more than two units apiece of O−, O+, A−, and A+ did not improve patient access.CONCLUSIONWhile some level of frozen blood is needed for rare blood, large inventories do not improve access. Modest amounts of frozen inventory, combined with increased door screening, provides the greatest chance of maximizing patient access.
Healthcare professionals’ perceptions and perspectives on biosimilar medicines and the barriers and facilitators to their prescribing in UK: a qualitative study
Authors: Aladul Mohammed Ibrahim , Fitzpatrick Raymond William , Chapman Stephen Robert 
Published: November 2018

ObjectiveTo investigate UK healthcare professionals’ perceptions and perspectives towards biosimilar infliximab, etanercept and insulin glargine and the potential barriers and facilitators to their prescribing.DesignA cross-sectional qualitative study design was used.SettingFive hospitals within the West Midlands area in UK.Interventions30 min face-to-face, semistructured interviews of healthcare professionals.Participants22 healthcare professionals (consultants, nurses and pharmacists) participated in the semistructured interviews.OutcomesParticipants’ opinion and attitudes about biosimilars and the barriers and facilitators to the prescribing of infliximab, etanercept and insulin glargine biosimilars in gastroenterology, rheumatology and diabetology specialties.ResultsThis study showed that UK healthcare professionals had good knowledge of biosimilars and were content to initiate them. Healthcare professionals disagreed with biosimilar auto-substitution at pharmacy level and multiple switching. Subtle differences among healthcare professionals were identified in the acceptance of switching stable patients, indication extrapolation and cost savings sharing.ConclusionSafety and efficacy concerns, patients’ opinion and how cost savings were shared were the identified barriers to considering prescribing biosimilars. Real-life data and financial incentives were the suggested facilitators to increase biosimilar utilisation.
Effect of two behavioural ‘nudging’ interventions on management decisions for low back pain: a randomised vignette-based study in general practitioners
Authors: Soon Jason , Traeger Adrian C , Elshaug Adam G. , Cvejic Erin , Maher Chris G , Doust Jenny A , Mathieson Stephanie , McCaffery Kirsten , Bonner Carissa 
Published: November 2018

Objective‘Nudges’ are subtle cognitive cues thought to influence behaviour. We investigated whether embedding nudges in a general practitioner (GP) clinical decision support display can reduce low-value management decisions .MethodsAustralian GPs completed four clinical vignettes of patients with low back pain. Participants chose from three guideline-concordant and three guideline-discordant (low-value) management options for each vignette, on a computer screen. A 2×2 factorial design randomised participants to two possible nudge interventions: ‘partition display’ nudge (low-value options presented horizontally, high-value options listed vertically) or ‘default option’ nudge (high-value options presented as the default, low-value options presented only after clicking for more). The primary outcome was the proportion of scenarios where practitioners chose at least one of the low-value care options.Results120 GPs (72% male, 28% female) completed the trial (n=480 vignettes). Participants using a conventional menu display without nudges chose at least one low-value care option in 42% of scenarios. Participants exposed to the default option nudge were 44% less likely to choose at least one low-value care option (OR 0.56, 95%CI 0.37 to 0.85; p=0.006) compared with those not exposed. The partition display nudge had no effect on choice of low-value care (OR 1.08, 95%CI 0.72 to 1.64; p=0.7). There was no interaction between the nudges (OR 0.94, 95% CI 0.41 to 2.15; p=0.89).InterpretationA default option nudge reduced the odds of choosing low-value options for low back pain in clinical vignettes. Embedding high value options as defaults in clinical decision support tools could improve quality of care. More research is needed into how nudges impact clinical decision-making in different contexts.
The first report of coronates (echinodermata) from Africa
Authors: Zamora S. , Sumrall C. D. 
Published: November 2018

Abstract

Coronates are widely distributed in Ordovician and Silurian rocks from Gondwana but have never been reported from Africa. A single theca of
Mespilocystites
sp. is the first representative of this blastozoan clade from the African continent, extending its geographical range. Previous reports of
Mespilocystites
include the Czech Republic, France, Italy, Portugal and Spain. The African specimen was collected from the Upper Ordovician (Katian) Upper Tiouririne Formation of the Moroccan Anti-Atlas Ranges, and is preserved in siliciclastic rocks associated with isorophid edrioasteroids and echinosphaeritid rhombiferans.
Dietary Tomato Powder Inhibits High-Fat Diet–Promoted Hepatocellular Carcinoma with Alteration of Gut Microbiota in Mice Lacking Carotenoid Cleavage Enzymes
Authors: Xia Hui , Liu Chun , Li Cheng-Chung , Fu Maobin , Takahashi Shingo , Hu Kang-Quan , Aizawa Koichi , Hiroyuki Suganuma , Wu Guojun , Zhao Liping , Wang Xiang-Dong 
Published: November 2018

Abstract
Both incidence and death rate due to liver cancer have increased in the United States. Higher consumption of lycopene-rich tomato and tomato products is associated with a decreased risk of cancers. β-Carotene-15, 15′-oxygenase (BCO1), and β-carotene-9′, 10′-oxygenase (BCO2) cleave lycopene to produce bioactive apo-lycopenoids. Although BCO1/BCO2 polymorphisms affect human and animal lycopene levels, whether dietary tomato consumption can inhibit high-fat diet (HFD)–promoted hepatocellular carcinoma (HCC) development and affect gut microbiota in the absence of BCO1/BCO2 is unclear. BCO1/BCO2 double knockout mice were initiated with a hepatic carcinogen (diethylnitrosamine) at 2 weeks of age. At 6 weeks of age, the mice were randomly assigned to an HFD (60% of energy as fat) with or without tomato powder (TP) feeding for 24 weeks. Results showed that TP feeding significantly decreased HCC development (67%, 83%, and 95% reduction in incidence, multiplicity, and tumor volume, respectively, P &lt; 0.05). Protective effects of TP feeding were associated with (1) decreased hepatic inflammatory foci development and mRNA expression of proinflammatory biomarkers (IL1β, IL6, IL12α, monocyte chemoattractant protein-1, and inducible NO synthase); (2) increased mRNA expression of deacetylase sirtuin 1 and nicotinamide phosphoribosyltransferase involving NAD+ production; and (3) increased hepatic circadian clock genes (circadian locomotor output cycles kaput, period 2, and cryptochrome-2, Wee1). Furthermore, TP feeding increased gut microbial richness and diversity, and significantly decreased the relative abundance of the genus Clostridium and Mucispirillum, respectively. The present study demonstrates that dietary tomato feeding independent of carotenoid cleavage enzymes prevents HFD-induced inflammation with potential modulating gut microbiota and inhibits HFD-promoted HCC development.
Catalogue of Neotropical Curtonotidae (Diptera, Ephydroidea)
Authors: Mello Ramon Luciano , Pereira-Colavite Alessandre 
Published: November 2018

The Neotropical species of Curtonotidae are updated and catalogued. A total of 33 species names are listed, including two fossil taxa and one nomem dubium. Valid and invalid names and synonyms are presented, totaling 45 names. Bibliographic references are given to all listed species, including information about name, author, year of publication, page number, type species and type locality. Lectotype and paralectotypes are designated to Curtonotum punctithorax (Fischer, 1933). Curtonotum simplex Schiner, 1868 stat. rev. is recognized as a valid name.
Prevalence and risk factors to <i>Leptospira</i> sp. infection in dogs attended at veterinary clinics in João Pessoa, Paraíba State, Northeastern Brazil
Authors: Brasil Arthur Willian de Lima , Da Costa Diego Figueiredo , Pimenta Carla Lauise Rodrigues Menezes , Parentoni Roberta Nunes , Alves Clebert José , Santos Carolina de Sousa Américo Batista , De Azevedo Sérgio Santos 
Published: November 2018

The aim of this study was to determine the prevalence and risk factors associated with Leptospira sp. in dogs attended at veterinary clinics in the city of João Pessoa, State of Paraíba, Northeast Brazil. A total of 384 blood samples from dogs from 34 veterinary clinics were used from April 2015 to May 2016. The diagnosis of Leptospira sp. was carried out through Microscopic Agglutination Test (MAT), using a collection of 20 pathogenic antigens and adopting a 1: 100 dilution as cutoff point. An epidemiological questionnaire was applied to the owners of the animals to obtain data to be used in the analysis of risk factors. The prevalence of seropositive animals was 11.7% (45/384), with reactions for serogroups Icterohaemorrhagiae (62.3%), Grippotyphosa (22.2%), Canicola (13.3%), Djasiman 2%) and Pomona (2.2%). The following risk factors were identified: age from 49 to 72 months (odds ratio = 2.74), Age > 72 months (odds ratio = 3.22), and monthly cleaning of the environment where the animals are kept (odds ratio = 10,70). It is concluded that dogs attended at veterinary clinics in João Pessoa are exposed to infection by Leptospira sp., with predominance of serogroups kept by wild animals, and it is suggested that the periodic cleaning of the environment where the animals are kept.
O Rei da Vela, A Navalha na Carne e a evolução do personagem homossexual no teatro brasileiro
Authors: Ferraresi Carolina De Melo 
Published: November 2018

Este artigo aborda dois personagens interpretados pelo ator Edgard Gurgel Aranha, falecido em 1990, em duas peças estreadas em 1967, O rei da vela e A navalha na carne. A partir de entrevistas com o próprio Edgard e com o ator Sérgio Mamberti, notícias de jornal e críticas da época, traça-se um panorama da evolução do personagem homossexual, refletindo o momento atual com base em obras tão emblemáticas e importantes para o teatro nacional.
Palavras-chave: Teatro Brasileiro, Homossexualidade, História do Teatro Brasileiro.