bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between synovial fluid cytokine concentrations and limb function in normal dogs and in dogs with lameness from spontaneous osteoarthritis
Authors: Allen Philip I. , Conzemius Michael G. , Evans Richard B. , Kiefer Kristina 
Published: April 2019

AbstractObjectiveTo determine the relationship between synovial biomarker concentrations and severity of lameness and to assess the ability to differentiate normal from osteoarthritic joints with synovial biomarker concentrations.Study designProspective clinical study.Sample populationTwelve hounds with no evidence of osteoarthritis (OA) and 27 client‐owned dogs with unilateral lameness and joint pain in a single joint from naturally occurring OA.MethodsEnrollment in the OA group required a history of lameness, radiographic evidence of OA on orthogonal joint radiographs, and ≥6% gait asymmetry between contralateral limbs. The concentrations of 14 synovial OA biomarkers in synovial samples obtained after gait analysis were measured with enzyme‐linked immunosorbent assays and compared between normal and OA joints.ResultsConcentrations of monocyte chemoattractant protein (MCP)‐1, substance P, interleukin (IL)‐6, IL‐8, KC‐like, matrix metalloproteinase (MMP)‐1, and MMP‐3 were greater (P ≤ .05) in OA than in normal joints. The concentrations of bradykinin and tissue inhibitors of metalloproteinase‐4 were decreased in OA compared with normal joints. Monocyte chemoattractant protein 1 was identified as the most accurate marker to distinguish OA from normal joints. No correlation was detected between any OA biomarker concentration, individually or in combination, and severity of gait asymmetry at the walk.ConclusionDifferences in proinflammatory and anti‐inflammatory biomarkers were detected between OA and normal joints, but no relationship was identified between biomarker concentrations and gait asymmetry in dogs with OA.Clinical impactThis information will help guide future studies to elucidate how factors such as disease chronicity, severity, and etiology affect these relationships.
First detection of Hepatitis E virus (Orthohepevirus C) in wild brown rats (Rattus norvegicus) from Great Britain
Authors: Murphy Ellen G. , Williams Nicola J. , Jennings Daisy , Chantrey Julian , Verin Ranieri , Grierson Sylvia , McElhinney Lorraine M. , Bennett Malcolm 
Published: April 2019

AbstractIn the United Kingdom, there has been an increase in the number of hepatitis E virus (HEV) infections in people annually since 2010. Most of these are thought to be indigenously acquired Orthohepevirus A genotype 3 (HEV G3), which has been linked to pork production and consumption. However, the dominant subgroup circulating in British pigs differs from that which is found in people; therefore, an alternative, potentially zoonotic, source is suspected as a possible cause of these infections. Rodents, brown rats (Rattus norvegicus) in particular, have been shown to carry HEV, both the swine HEV G3 genotype and Orthohepevirus C, genotype C1 (rat HEV). To investigate the prevalence of HEV in British rodents, liver tissue was taken from 307 rodents collected from pig farms (n = 12) and other locations (n = 10). The RNA from these samples was extracted and tested using a pan‐HEV nested RT‐PCR. Limited histopathology was also performed. In this study, 8/61 (13%, 95% CI, 5–21) of brown rat livers were positive for HEV RNA. Sequencing of amplicons demonstrated all infections to be rat HEV with 87%–92% nucleotide identity to other rat HEV sequences circulating within Europe and China (224 nt ORF‐1). Lesions and necrosis were observed histologically in 2/3 samples examined. No rat HEV RNA was detected in any other species, and no HEV G3 RNA was detected in any rodent in this study. This is the first reported detection of rat HEV in Great Britain. A human case of rat HEV infection has recently been reported in Asia, suggesting that rat HEV could pose a risk to public health.
Reviewer Acknowledgements
Authors: Young James 
Published: April 2019

International Journal of Social Science Studies (IJSSS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether IJSSS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 7, Number 3Ahmet Yıkmış, Abant Izzet Baysal Univeersity, TurkeyAmany Albert, Beni-Suef University, EgyptAmir Hossain, IBAIS University, BangladeshAnna Maria Mouza, Technological Educational Institution of Serres, GreeceAntónio Calha, Polytechnic Institute of Portalegre, PortugalAslan,Yasin, Sinop University, TurkeyBassam Yousef Ibrahim Banat, Al-Quds University, PalestineBegoña Montero-Fleta, Universitat Politécnica de València, SpainBo Li, St Ambrose University, USAChris Gilleard, University College London, UKEmanuele Achino, C. D. T. O., ItalyFernando Aragón-Durand, National Autonomous University of Mexico, MexicoGonzalo Capellan-Miguel, Spanish Minister of Education in United Kingdom, SpainHao Liu, Beijing Normal University, ChinaHenry Poduthas, West Texas A&M University, USAHyejin Lee, Tufts University, MA, USA and Konkuk University, Seoul, South Korea, USAJesster Pasule Eduardo, Nueva Ecija University of Science and Technology, PhilippinesJulia M. Mack, Gannon University, USALaura Diaconu Maxim, "Alexandru Ioan Cuza University" of Iasi, RomaniaLing Wei, China Foreign Affairs University, ChinaMałgorzata Haładewicz, Opole University of Technology, PolandMasami Tsuji, Meiji University, JapanMei-Ling Lin, National Open University, TaiwanMickey Langlais, University of Nebraska – Kearney, USAMikiyasu Nakayama, the University of Tokyo, JapanMohamed Mehdi Jelassi, IHEC Carthage, TunisiaMohammad Naji Shah Mohammadi, Kuala Lumpur, MalaysiaOzgur Demirtas, Inonu University, TurkeyRachita Shrivastava Roy, Department of Higher Education, Chhatisgarh-India, IndiaRakesh Arya, Jawaharlal Nehru University, New Delhi, India Raymond Chan, City University of Hong Kong, Hong KongRemigiusz Kijak, "University of Warsaw, PolandRenu, Central University of Haryana, India Riam Elmorshedy, South Valley University, EgyptRodrigo Cabrera Pertusatti, University of Buenos Aires, ArgentinaSana Ali, Allama Iqbal Open University, Islamabad, PakistanSandro Serpa, University of the Azores, PortugalSharif Alghazo, University of Jordan, JordanShariq aziz butt, Superior University Lahore, PakistanYanzhe Zhang, Jilin University, China
Greening Our Front Porch: Environmental Sustainability in Collegiate Athletics
Authors: Pelcher Jamee A. , McCullough Brian P. 
Published: April 2019

Sport organizations have begun to widely implement environmental sustainability into their daily operations, but more needs to be done to properly plan and implement these initiatives to ensure their long-term success. Specifically, college athletic departments struggle to be proactive in their approach to environmental sustainability despite the vast resources available to leverage in order to deeply commit to being an environmentally sustainable department on campus. This case study examines the strategic planning of sustainability initiatives in the Smallville University Athletic Department. This case provides students with an opportunity to (a) explore the importance of sustainability in sport, (b) analyze the role of stakeholders in a sports organization, (c) investigate common barriers to implementing sustainability in college athletics, and (d) consider creative options for implementing sustainable initiatives.
Combining Plant Sterols With Walking Lowers Postprandial Triacylglycerol More Than Walking Only in Chinese Men With Elevated Body Mass Index
Authors: Lye Ching T. , Mukherjee Swarup , Burns Stephen F. 
Published: April 2019

This study examined if plant sterols and walking reduce postprandial triacylglycerol (TAG) concentrations in Chinese men with elevated body mass index (≥ 23.5 kg/m2). Fifteen Chinese men (mean [SD]: age = 25 [3] years and body mass index = 26.2 [1.5] kg/m2] completed four 10-day trials in random order with a 7- to 10-day washout between trials: (a) daily consumption of a control margarine while sedentary (C-S), (b) daily consumption of margarine containing 2 g/day of plant sterols while sedentary (PS-S), (c) daily consumption of a control margarine with 30-min daily walking (C-W), and (d) daily consumption of margarine containing 2 g/day of plant sterols with 30-min daily walking (PS-W). On Day 11 of each trial, postprandial TAG was measured after a high-fat milkshake. The 5-hr total area under the TAG curve was 22%, 25%, and 12% lower on PS-W (mean [SD]: 8.9 [4.3] mmol·5 hr/L) than C-S (11.4 [4.5] mmol·5 hr/L; p = .005; d = 0.56), PS-S (11.9 [4.9] mmol·5 hr/L; p = .004; d = 0.67), and C-W (10.1 [4.4] mmol·5 hr/L; p = .044; d = 0.27) trials, respectively. Similarly, 5-hr incremental area for PS-W (4.5 [2.7] mmol·5 hr/L) was 31%, 32%, and 18% lower than C-S (6.6 [3.3] mmol·5 hr/L; p = .005; d = 0.62), PS-S (6.6 [3.4] mmol·5 hr/L; p = .004; d = 0.64), and C-W (5.5 [2.8] mmol·5 hr/L; p = .032; d = 0.29). Ten days of daily plant sterol intake combined with walking presents an intervention strategy to lower postprandial TAG in Chinese men with elevated body mass index.
Rapid Weight Loss Practices in Elite Kickboxers
Authors: Dugonjić Boris , Krstulović Saša , Kuvačić Goran 
Published: April 2019

The aim of this observational cross-sectional survey was to determine the prevalence of rapid weight loss (RWL) in elite kickboxers. Kickboxers (61 males; age = 24.2 ± 4.6 years, weight = 73.9 ± 12.8 kg, and height = 179.2 ± 7.9 cm) from eight European countries completed a Rapid Weight Loss Questionnaire regarding prevalence, magnitude, and methods of RWL. All athletes (100%) were practicing RWL before the competition with a Rapid Weight Loss Questionnaire score of 52.4 ±12.9. Most kickboxers ‘usually lose between 2% and 5% of their body mass, whereas ∼30% lose between 6% and 8%. However, it is alarming that almost 30% reported cutting 10% of body weight or more sometime during their kickboxing career. Almost half of the athletes always practice gradual dieting (45.9%) and increased exercising (44.3%) to reduce body mass. Kickboxers usually reduce weight three to four times during a year, usually 7–15 days before a competition. More than a third (34.4%) started with RWL practice under the age of 17. There was no significant difference between weight divisions in weight management behaviors (p = .5, F = 0.6; η2 = .0) and no relation between the main characteristics of elite kickboxing athletes and the total RWL score. In conclusion, RWL practices in kickboxing athletes are somewhat specific and different when compared with other combat sports, which can be explained by greater number of weight classes and specific weigh-in protocol.
Gastrointestinal Effects of Exogenous Ketone Drinks are Infrequent, Mild, and Vary According to Ketone Compound and Dose
Authors: Stubbs Brianna J. , Cox Pete J. , Kirk Tom , Evans Rhys D. , Clarke Kieran 
Published: April 2019

Exogenous ketone drinks may improve athletic performance and recovery, but information on their gastrointestinal tolerability is limited. Studies to date have used a simplistic reporting methodology that inadequately represents symptom type, frequency, and severity. Herein, gastrointestinal symptoms were recorded during three studies of exogenous ketone monoester (KME) and salt (KS) drinks. Study 1 compared low- and high-dose KME and KS drinks consumed at rest. Study 2 compared KME with isocaloric carbohydrate (CHO) consumed at rest either when fasted or after a standard meal. Study 3 compared KME+CHO with isocaloric CHO consumed before and during 3.25 hr of bicycle exercise. Participants reported symptom type and rated severity between 0 and 8 using a Likert scale at regular intervals. The number of visits with no symptoms reported after ketone drinks was n = 32/60 in Study 1, n = 9/32 in Study 2, and n = 20/42 in Study 3. Following KME and KS drinks, symptoms were acute but mild and were fully resolved by the end of the study. High-dose KS drinks caused greater total-visit symptom load than low-dose KS drinks (13.8 ± 4.3 vs. 2.0 ± 1.0; p < .05) and significantly greater time-point symptom load than KME drinks 1–2 hr postdrink. At rest, KME drinks caused greater total-visit symptom load than CHO drinks (5.0 ± 1.6 vs. 0.6 ± 0.4; p < .05). However, during exercise, there was no significant difference in total-visit symptom load between KME+CHO (4.2 ± 1.0) and CHO (7.2 ± 1.9) drinks. In summary, exogenous ketone drinks cause mild gastrointestinal symptoms that depend on time, the type and amount of compound consumed, and exercise.
No Effect of Partial-Body Cryotherapy on Restoration of Countermovement Jump or Well-Being Performance in Elite Rugby Union Players During the Competitive Phase of the Season
Authors: Grainger Adam , Comfort Paul , Heffernan Shane 
Published: April 2019

Purpose:Partial body cryotherapy (PBC) has been shown to be beneficial for postexercise recovery; however, no study has demonstrated the effectiveness of PBC for recovery following elite rugby union training. Rugby union is a unique sport that involves high-velocity collisions and may induce greater performance decrements than other sports; thus, PBC could be beneficial. The application of PBC in “real world” has rarely been investigated during the competitive phase of a playing season and warranted investigation.Methods:In a counterbalanced sequential research design, professional rugby athletes (n = 18; age 25.4 [4.0] y; training age 7.2 [4.0] y; mass 99.8 [10.6] kg; height 188.3 [6.0] cm) were assigned to a 12-week PBC intervention, washout period (4 wk), and reassessed as their own controls. Self-reported well-being, muscle soreness, sleep quality, and countermovement jump height were assessed before and 40 hours after “real-world” training. Wilcoxon signed-rank tests and Cohendwere used for statistical analysis.Results:No differences were observed between PBC and control conditions (P > .05;d = 0.00–0.14) for well-being (−0.02% [0.08%] vs 0.01% [0.06%]), muscle soreness (−0.01% [0.11%] vs 0.01% [0.16%]), sleep quality (−0.03% [0.14%] vs 0.10% [0.29%]), or countermovement jump height (36.48–36.59 vs 38.13–37.52 cm;P = .54).Conclusions:These results suggest PBC is ineffective for the restoration of selected performance parameters during the performance maintenance phase of the competitive season. To ascertain the appropriation of its use, future investigations should seek to assess the use of cryotherapies at various phases of the elite rugby union competitive season.
OP TRENTON 3: An analysis of primary care presentations to a deployed role 1 in support of a United Nation peacekeeping operation
Authors: Bonham Christopher Thomas , Pallett S J C , Holland T J 
Published: April 2019

ObjectivesHealth data of operational relevance from South Sudan are lacking, outdated and non-representative. This study sets out to record and analyse primary healthcare (PHC) presentations to a deployed UK Level 1 Primary Healthcare Centre (L1 PHC) facility in Bentiu, South Sudan, to inform on disease prevalence for UK Military Personnel in a sub-Saharan Operational environment.MethodsA prospective single-centre cohort study was completed for all PHC presentations to a UK L1 PHC facility while deployed on the United Nations Mission to South Sudan from June 2017 to November 2017.Results861 episodes of clinical care were recorded at Bentiu Camp during the 6-month period. 82% were from disease; 18% non-battle injuries and no battle injuries were seen. As per EPINATO2 categorisation, the top three presentations were acute gastrointestinal disease, dermatological disease and routine clinical care. Differences were noted for June–August and September–November, as a proportion of total cases seen. It was noted that gastrointestinal illnesses were three times more likely in the first half of the operation and bites and sting almost twice as likely.ConclusionsGastrointestinal disease results in a significant burden on humanitarian operations where an extended Relief-in-Place is a key area of risk. The EPINATO2 reporting tool provides insufficient detail for planning purposes and an improved method of data collection is required. Targeting the diagnosis and management of infectious diseases during predeployment training should prepare L1 PHC for the most common cases encountered. Delivery of targeted Force Health Protection training for all personnel with early deployment of L1 PHC forward could improve support to commanders during the highest risk periods.
EZH2 Is Overexpressed in BRCA1-like Breast Tumors and Predictive for Sensitivity to High-Dose Platinum-Based Chemotherapy
Authors: Puppe Julian , Opdam Mark , Schouten Philip C. , Jóźwiak Katarzyna , Lips Esther , Severson Tesa , van de Ven Marieke , Brambillasca Chiara , Bouwman Peter , van Tellingen Olaf , Bernards René , Wesseling Jelle , Eichler Christian , Thangarajah Fabinshy , Malter Wolfram , Pandey Gaurav Kumar , Ozretić Luka , Caldas Carlos , van Lohuizen Maarten , Hauptmann Michael , Rhiem Kerstin , Hahnen Eric , Reinhardt H. Christian , Büttner Reinhard , Mallmann Peter , Schömig-Markiefka Birgid , Schmutzler Rita , Linn Sabine , Jonkers Jos 
Published: April 2019

Abstract

Purpose:
BRCA1-deficient breast cancers carry a specific DNA copy-number signature (“BRCA1-like”) and are hypersensitive to DNA double-strand break (DSB) inducing compounds. Here, we explored whether (i) EZH2 is overexpressed in human BRCA1-deficient breast tumors and might predict sensitivity to DSB-inducing drugs; (ii) EZH2 inhibition potentiates cisplatin efficacy in Brca1-deficient murine mammary tumors.

Experimental Design:
EZH2 expression was analyzed in 497 breast cancers using IHC or RNA sequencing. We classified 370 tumors by copy-number profiles as BRCA1-like or non-BRCA1–like and examined its association with EZH2 expression. Additionally, we assessed BRCA1 loss through mutation or promoter methylation status and investigated the predictive value of EZH2 expression in a study population of breast cancer patients treated with adjuvant high-dose platinum-based chemotherapy compared with standard anthracycline-based chemotherapy. To explore whether EZH2 inhibition by GSK126 enhances sensitivity to platinum drugs in EZH2-overexpressing breast cancers we used a Brca1-deficient mouse model.

Results:
The highest EZH2 expression was found in BRCA1-associated tumors harboring a BRCA1 mutation, BRCA1-promoter methylation or were classified as BRCA1 like. We observed a greater benefit from high-dose platinum-based chemotherapy in BRCA1-like and non-BRCA1–like patients with high EZH2 expression. Combined treatment with the EZH2 inhibitor GSK126 and cisplatin decreased cell proliferation and improved survival in Brca1-deficient mice in comparison with single agents.

Conclusions:
Our findings demonstrate that EZH2 is expressed at significantly higher levels in BRCA1-deficient breast cancers. EZH2 overexpression can identify patients with breast cancer who benefit significantly from intensified DSB-inducing platinum-based chemotherapy independent of BRCA1-like status. EZH2 inhibition improves the antitumor effect of platinum drugs in Brca1-deficient breast tumors in vivo.
High-Sensitivity Troponin I and Incident Coronary Events, Stroke, Heart Failure Hospitalization, and Mortality in the ARIC Study
Authors: Jia Xiaoming , Sun Wensheng , Hoogeveen Ron C. , Nambi Vijay , Matsushita Kunihiro , Folsom Aaron R. , Heiss Gerardo , Couper David J. , Solomon Scott D. , Boerwinkle Eric , Shah Amil , Selvin Elizabeth , de Lemos James A. , Ballantyne Christie M. 
Published: April 2019

Background:
We assessed whether plasma troponin I measured by a high-sensitivity assay (hs-TnI) is associated with incident cardiovascular disease (CVD) and mortality in a community-based sample without prior CVD.

Methods:
ARIC study (Atherosclerosis Risk in Communities) participants aged 54 to 74 years without baseline CVD were included in this study (n=8121). Cox proportional hazards models were constructed to determine associations between hs-TnI and incident coronary heart disease (CHD; myocardial infarction and fatal CHD), ischemic stroke, atherosclerotic CVD (CHD and stroke), heart failure hospitalization, global CVD (atherosclerotic CVD and heart failure), and all-cause mortality. The comparative association of hs-TnI and high-sensitivity troponin T with incident CVD events was also evaluated. Risk prediction models were constructed to assess prediction improvement when hs-TnI was added to traditional risk factors used in the Pooled Cohort Equation.

Results:

The median follow-up period was ≈15 years. Detectable hs-TnI levels were observed in 85% of the study population. In adjusted models, in comparison to low hs-TnI (lowest quintile, hs-TnI ≤1.3 ng/L), elevated hs-TnI (highest quintile, hs-TnI ≥3.8 ng/L) was associated with greater incident CHD (hazard ratio [HR], 2.20; 95% CI, 1.64–2.95), ischemic stroke (HR, 2.99; 95% CI, 2.01–4.46), atherosclerotic CVD (HR, 2.36; 95% CI, 1.86–3.00), heart failure hospitalization (HR, 4.20; 95% CI, 3.28–5.37), global CVD (HR, 3.01; 95% CI, 2.50–3.63), and all-cause mortality (HR, 1.83; 95% CI, 1.56–2.14). hs-TnI was observed to have a stronger association with incident global CVD events in white than in black individuals and a stronger association with incident CHD in women than in men. hs-TnI and high-sensitivity troponin T were only modestly correlated (
r
=0.47) and were complementary in prediction of incident CVD events, with elevation of both troponins conferring the highest risk in comparison with elevation in either one alone. The addition of hs-TnI to the Pooled Cohort Equation model improved risk prediction for atherosclerotic CVD, heart failure, and global CVD.

Conclusions:
Elevated hs-TnI is strongly associated with increased global CVD incidence in the general population independent of traditional risk factors. hs-TnI and high-sensitivity troponin T provide complementary rather than redundant information.
DREAM: A Challenge Data Set and Models for Dialogue-Based Reading Comprehension
Authors: Sun Kai , Yu Dian , Chen Jianshu , Yu Dong , Choi Yejin , Cardie Claire 
Published: April 2019

We present DREAM, the first dialogue-based multiple-choice reading comprehension data set. Collected from English as a Foreign Language examinations designed by human experts to evaluate the comprehension level of Chinese learners of English, our data set contains 10,197 multiple-choice questions for 6,444 dialogues. In contrast to existing reading comprehension data sets, DREAM is the first to focus on in-depth multi-turn multi-party dialogue understanding. DREAM is likely to present significant challenges for existing reading comprehension systems: 84% of answers are non-extractive, 85% of questions require reasoning beyond a single sentence, and 34% of questions also involve commonsense knowledge. We apply several popular neural reading comprehension models that primarily exploit surface information within the text and find them to, at best, just barely outperform a rule-based approach. We next investigate the effects of incorporating dialogue structure and different kinds of general world knowledge into both rule-based and (neural and non-neural) machine learning-based reading comprehension models. Experimental results on the DREAM data set show the effectiveness of dialogue structure and general world knowledge. DREAM is available at https://dataset.org/dream/ .