bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of self-testing kits availability on improving HIV testing frequency for chinese men who have sex with men and their sexual partners: a protocol for a multicenter randomised controlled trial
Authors: Zhang Ci , Li Xianhong , Koniak-Griffin Deborah , Goldsamt Lloyd A. , Zhou Jing 
Published: December 2018

IntroductionHIV epidemic is increasing among men who have sex with men (MSM) in China, yet HIV testing uptake remains low. As an emerging approach, HIV self-testing (HIVST) has the potential to promote HIV testing coverage and frequency in this population. However, evidence of the effectiveness on implementation of HIVST among Chinese MSM and their sexual partners is scarce.Methods and analysisThe randomised controlled trial will be performed in Changsha, Changde, Shaoyang and Yiyang, Hunan province, China, recruiting 184 recent testers (men who had at least one HIV test within the past 2 years) and 26 non-recent testers (men who did not have HIV tests within 2 years or never had an HIV test). Eligible men will be randomly divided 1:1 into two groups: intervention (with free HIVST kits plus site-based HIV testing services) and control (site-based HIV testing services only). Participants in the intervention group will be provided with two free finger-prick-based HIVST kits, and can apply for two to four kits every 3 months for 1 year.Participants in both groups will complete questionnaires via WeChat at five separate times: baseline, third, sixth, ninth and twelfth month. The primary outcome is the mean number of HIV tests for MSM over the 12-month study period. The secondary outcome is the mean number of HIV tests for sexual partners of MSM over the 12-month study period. The tertiary outcomes are the self-reported proportion of consistent condom usage for anal sex, and the numbers of sexual partners during the 12-month study period.Ethics and disseminationThe study has been approved by the Institutional Review Board of Behavioural and Nursing Research in Xiangya School of Nursing of Central South University, China (2018002). Study results will be disseminated through conferences and academic journals.Trial registration numberChiCTR1800015584; Pre-results.
Role of diffusional kurtosis imaging in grading of brain gliomas: a protocol for systematic review and meta-analysis
Authors: Abdalla Gehad , Sanverdi Eser , Machado Pedro M , Kwong Joey S W , Panovska-Griffiths Jasmina , Rojas-Garcia Antonio , Yoneoka Daisuke , Yousry Tarek , Bisdas Sotirios 
Published: December 2018

IntroductionCentral nervous system (CNS) gliomas are the most common primary intra-axial brain tumours and pose variable treatment response according to their grade, therefore, precise staging is mandatory. Histopathological analysis of surgical tumour samples is still deemed as the state-of-the-art staging technique for gliomas due to the moderate specificity of the available non-invasive imaging modalities. A recently evolved analysis of the tissue water diffusion properties, known as diffusional kurtosis imaging (DKI), is a dimensionless metric, which quantifies water molecules’ degree of non-Gaussian diffusion, hence reflects tissue microenvironment’s complexity by means of non-invasive diffusion-weighted MRI acquisitions. The objective of this systematic review and meta-analysis is to explore the performance of DKI in the presurgical grading of gliomas, both regarding the differentiation between high-grade and low-grade gliomas as well as the discrimination between gliomas and other intra-axial brain tumours.Methods and analysisWe will search PubMed, Medline via Ovid, Embase and Scopus in July 2018 for research studies published between January 1990 and June 2018 with no language restrictions, which have reported on the performance of DKI in diagnosing CNS gliomas. Robust inclusion/exclusion criteria will be applied for selection of eligible articles. Two authors will separately perform quality assessment according to the quality assessment of diagnostic accuracy studies-2 tool. Data will be extracted in a predesigned spreadsheet. A meta-analysis will be held using a random-effects model if substantial statistical heterogeneity is expected. The heterogeneity of studies will be evaluated, and sensitivity analyses will be conducted according to individual study quality.Ethics and disseminationThis work will be based on published studies; hence, it does not require institutional review board approval or ethics clearance. The results will be published in peer-reviewed journals.PROSPERO registration numberCRD42018099192.
Is There A Relation Between Serum Uric Acid Values and Prostatic Calculi Presence?
Authors: Balasar Mehmet , Sönmez Mehmet Giray , Aydın Arif , Göger Yunus Emre , Özkent Mehmet Serkan , Poyraz Necdet 
Published: December 2018

<b><i>Objective:</i></b> We planned to examine the connection between serum uric acid (UA) values and prostatic calculi (PCal) presence and to evaluate the relation between PCal and other etiological factors. <b><i>Methods:</i></b> Patients between 20 and 60 years of age who were referred to the clinic with any reason and had non-contrast abdominal tomography (NCACT) for PCal were included in the study. While the patients were separated into 2 groups based on their serum UA level as ≥7 mg/dL (Group 1) and &#x3c; 7 mg/dL (Group 2), NCACT was also divided into 2 groups as PCal presence (PCal+) and lack (PCal–) serum UA, calcium, phosphorus, sodium, prostate-specific antigen levels and urinary analysis results of the patients were evaluated and compared. <b><i>Results:</i></b> PCal were detected in 38 of 169 patients (22%). PCal presence was detected to be significantly high in Group 1 (<i>p</i> = 0.015). While Type A localization PCal were present both in Groups 1 and 2. Based on PCal presence, UA level was detected to be significantly high in PCal+ patients (<i>p</i> = 0.01). No significant difference was detected among the groups in biochemical parameters and urine-related parameters other than UA. <b><i>Conclusion:</i></b> A significant relation was found between high UA value and PCal in this study. These results may show that UA plays an active role in PCal etiology.
Stroke After Percutaneous Coronary Intervention in the Era of Transradial Intervention
Authors: Shoji Satoshi , Kohsaka Shun , Kumamaru Hiraku , Sawano Mitsuaki , Shiraishi Yasuyuki , Ueda Ikuko , Noma Shigetaka , Suzuki Masahiro , Numasawa Yohei , Hayashida Kentaro , Yuasa Shinsuke , Miyata Hiroaki , Fukuda Keiichi 
Published: December 2018

Background:
Periprocedural stroke is a rare but life-threatening complication of percutaneous coronary intervention (PCI). Transradial intervention (TRI) is more beneficial than transfemoral intervention for periprocedural bleeding and acute kidney injuries, but its effect on periprocedural stroke has not been fully investigated. Our study aimed to assess risk predictors of periprocedural stroke according to PCI access site.

Methods and Results:

Between 2008 and 2016, 17 966 patients undergoing PCI were registered in a prospective multicenter database. Periprocedural stroke was defined as loss of neurological function caused by an ischemic or hemorrhagic event with residual symptoms lasting at least 24 hours after onset. Periprocedural stroke was observed in 42 patients (0.3%). Stroke patients were older and had a higher incidence of chronic kidney disease, peripheral artery disease, and acute coronary syndrome but were less likely to undergo TRI. Multivariable logistic regression analysis revealed TRI (odds ratio; 0.33; 95% CI, 0.16–0.71;
P
=0.004) was significantly associated with a lower occurrence of periprocedural stroke. Finally, propensity score–matching analysis showed that TRI was associated with a reduced risk of periprocedural stroke compared with transfemoral intervention (0.1% versus 0.4%;
P
=0.014). According to our sensitivity analysis, this finding was robust to the presence of an unmeasured confounder in almost all plausible scenarios.

Conclusions:
TRI was associated with a reduced risk of periprocedural stroke compared with transfemoral intervention. Increased TRI use may reduce overall PCI complications and should be recommended as the optimal access site for both urgent/emergent and elective PCIs.
Ugo Monneret de Villard (1881–1954) and the Establishment of Islamic Art Studies in Italy
Authors: Armando Silvia 
Published: December 2018

Ugo Monneret de Villard was the main Italian scholar of Islamic art in the twentieth century. Where and why did this engineer from Milan start cultivating this interest? How did his work come to be appreciated at the highest academic levels? This article delineates Monneret’s long training through an examination of his readings and writings, travels, and exchanges with other scholars, all of which influenced his working methodology, leading him to archaeological missions in Africa and predisposing his discovery of Islamic art. A fundamental focus is given to the idea of studying Islamic art objects and monuments in Italy. Unpublished archival sources reveal that in the mid-1930s Monneret was the essential point of reference of a group of intellectuals, distant from the academic Scienza ufficiale, whose intention was to promote the study of Islamic art in Italy. These intellectuals had the double goal of instituting a chair of Islamic art and of preserving the Islamic artistic heritage of southern Italy. Newly discovered documents reveal the early civic engagement and nature of a project that manifested itself years later in Monneret’s catalogue “Opere di arte islamica in Italia,” unfortunately still unpublished.  The missed opportunity of creating an academic post demonstrates the scant attention given to the discipline by Italian public institutions. On the other hand, Monneret’s original interest in the Cappella Palatina ceilings is seen to be part of his broader project. A fresh look at already known sources allows us to reconstruct the editorial phases of Monneret’s masterpiece and discloses the fundamental role played by American institutions and scholars.  Monneret de Villard’s multifaceted scientific profile is the “lens” through which it is possible to examine the history of Islamic art studies in Italy in the first half of the twentieth century.
Immigrant Narratives: The Ottoman Sultans’ Portraits in Elisabeth Leitner’s Family Photo Album, circa 1862–72
Authors: Avcıoğlu Nebahat 
Published: December 2018

Abstract
This article is a study of the family photo album of Elisabeth Leitner (ca. 1842?–1908), a Hungarian immigrant in the Ottoman empire. The album contains a complete set of cartes de visite portraits of the Ottoman sultans by the Abdullah Frères. As the only surviving example of such a collection with a known provenance, it provides a rare opportunity for understanding how such images were used in the context of identity formation and social mobility undertaken by a member of the immigrant population. The album, which has never been studied before, is also a fascinating source for investigating the history of Hungarian immigrants in the Ottoman empire who were displaced after the 1848 Revolution. The article approaches the intriguingly autobiographical album by means of a close reading of Elisabeth Leitner’s diaries and unfinished autobiography. My interpretation serves to dismantle notions of a carefree global cosmopolitanism and exposes a historiographical bias that privileges men and their collections of images and ethnographic artifacts over those of women. Elisabeth Leitner’s writings and photographic collection also represent a vast and entirely untapped resource for investigating cultural contacts between Europe and the Ottoman empire in the second half of the nineteenth century.
The Shahi ʿIdgah of 1312 at Rapri (Uttar Pradesh): A Landmark in Indian Glazed Tiles
Authors: Porter Yves 
Published: December 2018

Abstract
The Shahi ʿIdgah at Rapri (Uttar Pradesh), which dates to 1312, was built by Malik Kafur, the general of the Delhi sultan ʿAla⁠ʾuddin Khalji (1296–1316). The village of Rapri was part of Malik Kafur’s fief and an important station for the army, as it commanded a ford on the Yamuna River. ʿĪdgāhs, sometimes translated as “wall-mosques,” are extra-urban, open prayer spaces for accommodating large congregations during the two main religious festivals (ʿīds). The Rapri ʿīdgāh constitutes a major landmark in the architecture of the Delhi Sultanate, mainly because of its exceptional decoration of turquoise-glazed tiles, the oldest example of its kind still in situ. Although often considered a technique that originated in the Iranian domains, the making of glazed tiles was already known in the Kushan period (first to fourth century CE), and some findings have been excavated from Buddhist contexts in the nearby Mathura region. This study shows the link between the tiles of Rapri and later fourteenth century examples, and with glazed pottery.
A Preliminary Study of a Nineteenth-Century Persian Manuscript on Porcelain Manufacture in the Sipahsalar Library, Tehran
Authors: Matin Mehran , Matin Moujan 
Published: December 2018

Abstract
The Risāla dar tafṣīl-i sākhtan-i chīnī (A Treatise on Porcelain Manufacture) is a Qajar-period manuscript in Persian, housed at the Sipahsalar Library in Tehran. It is the only known source that details the modern technology of porcelain production in the Qajar era (1789–1925). According to the information in the colophon, the scribe, Masih ibn Muhammad Baqir al-Firuzabadi, completed the manuscript in the year 1284 (1868). The text mentions that it is the translation of a French work, but no further reference to the original book is given. The purpose of this essay is to introduce and review the Persian manuscript, to reveal its relation to the three-volume Traité des arts céramiques ou des poteries (Treatise on Ceramic Arts or Potteries) by Alexandre Brongniart, a nineteenth-century scientist and director of the Sèvres Porcelain Factory, and to underline its importance to the history of art and technology in Qajar Iran.
Investment Protection of Commercial Activities in Space: Treaties, Contracts, Licenses, Insurance, Arbitration
Authors: Malanczuk Peter 
Published: December 2018

Abstract
The article focuses on the protection of foreign investment against political risk in the host state regarding commercial activities in outer space, an area not subject to national appropriation and sovereignty. The general space treaty and national legal frameworks for such activities fail to address the needs of private space enterprises. Under international investment law, commercial space activities generally meet common subject matter scope definitions of ‘investment’ and ‘investor’ in investment treaties. But foreign acquisitions in the space industry may affect national security interests of the host state and be limited as a sector for foreign investment. Moreover, as investment treaties generally cover an investment only if it is made in the territory of the host state, uncertainties may arise as to whether activities and assets of space enterprises in outer space are covered.
早期漢語言文學研究中的漢字釋讀方法新探
Authors: Hill Nathan W. 
Published: December 2018

提要
本文綜述以楷書轉寫早期文獻的過時做法中的常見錯誤，並提出將漢字承載的音義信息譯解為羅馬字母的直接釋讀漢字的方法。
An introduction to the tonogenesis triggered by breathy voice: 對舟曲藏語超音段音素的新見解——被氣聲引起的聲調發生論
Authors: Suzuki Hiroyuki 
Published: December 2018

提要
分佈在甘肅省甘南州的一個獨立藏語方言群舟曲藏語在以往研究中被認為是個具有聲調對立的語言。但本文指出此藏語尚未有音高對立,并僅有以氣聲發聲態為主的超音段特徵,而且氣聲也還沒成為音系對立中的一部份而是個喉擦音/ɦ/的語音變體。本文討論舟曲藏語之兩個土話,即拱壩話及八楞話,其中氣聲在拱壩話比八楞話出現得更明顯。此差異源於/ɦ/在音系上的功能程度之別。
Exploration on the Orignal Meaning of “Temperament” by the Theory of Words’ Value (以詞的價值理論探求“脾氣”之本義)
Authors: Nkrumah (晴朗) Bright , Huang (黃耀明) Yaoming 
Published: December 2018

The original meaning of “temperament” 脾氣 was explained with “the function of spleen” or “the disease of spleen” by the previous scholars is wrong and the explanation of “the Qi 氣 of spleen” is ambiguous. The earliest record about the word of “temperament” 脾氣 comes from the Historical Records 史記, and this book belongs to the language system of the Yellow Emperor’s Canon of Medicine 黃帝內經. By the Theory of Words’ Value, after analyzing the 593 words or phrases of including “Qi” 氣 in the Yellow Emperor’s Canon of Medicine 黃帝內經, the orignal meaning of “Qi” 氣 and “temperament” 脾氣 is inferred. Finally, this paper concludes that the orignal meaning of “temperament” is an essence and a tiny particle which produced by the water and food in the spleen and stomach, and has the functions of maintaining the physiological activities of the spleen, nourishing the body and resisting diseases.
前人辭書將“脾氣”本義釋爲“脾的功能”“脾臟之病”有誤，而釋爲“脾的精氣”則表述模糊。“脾氣”最早見於《史記》，其文與《黃帝內經》屬同一系統。根據詞的價值理論分析《黃帝內經》593條含“氣”詞目，據以推測其“氣”“脾氣”的本義。結果表明：“脾氣”本義爲由脾胃中的水穀產生的，具有維持脾臟生理活動、滋養人體、抵禦病邪等功能的精微物質。
The Original Character of tan3 in Southern Min (閩南語 tan3（投擲；丟棄）本字考)
Authors: Teng (滕暢) Chang 
Published: December 2018

In this paper, we find the original character of ‘tan3’ which means throwing or casting off in Southern Min. In the first section, we review the ways of the traditional writing characters in Southern Min and then we put forward our argument. In section 2, we list the possible cognates in Leizhou Min, Hakka, Cantonese, Xiang, Gan, Wu, Jin and Chinese Mandarin. We explain the reason from the aspect of sound correspondence and sound change for the above possible cognates and find the meaning ‘hit’ of it. In section 3, we present a detailed analysis of the potential original character and cite a lot of example sentences as evidences. Then we prove that the potential original character has the meaning ‘hit’ by the study on the word family of it. In section 4, we find that the original character of ‘tiŋ3’ in Southern Min which means hitting is the same as the original character of ‘tan3’. We also list some other characters which have the meaning ‘throw’ in Southern Min in order to prove the argument. In the last section, we rethink the reasons why we can find the original character of ‘tan3’ in Southern Min.
本文考出閩南語中表達「投擲；丟棄」之義的tan3的本字為「打」。本文在第1節中首先回顧了閩南語tan3的常見寫法並逐一討論，再提出本文論點；在第2節中列出其在閩南雷州方言、客方言、粵方言、湘方言、贛方言、吳方言、晉方言、官話中可能的同源詞，一方面證明「釘」字與該詞素音讀吻合、而「打」字僅存在聲調上的差異，另一方面發現這一可能的同源詞在方言間除「投擲」義外另有「擊打」義；在第3節中首先回顧「丁」詞族的「釘」「打」二字在古文獻中的用法，從中發現「打」字表示「擊打」「擲擊」義的例證，進而釐清「打」字「擊打——擲擊——投擲」的語義發展脈絡，以此證明論點；在第4節中敘述「釘」字在閩南語中的用法，分析並證明「孤對tiŋ3」「tiŋ3孤枝」兩詞中tiŋ3的本字亦為「打」，此外還通過閩南語中其它表示「投擲」之義的語詞「掔」「揕」「㧒」等輔助論證；在第5節中提出一些反思。
Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5
Authors: Shen Qingya , Qiu Zhiyu , Wu Wenping , Zheng Jimin , Jia Zongchao 
Published: December 2018

ABSTRACT
Phosphoenolpyruvate carboxykinase (PEPCK1) is ubiquitinated by E3 ubiquitin ligase UBR5, which was thought to be facilitated by the acetylation of Lys70, Lys71 and Lys594 in PEPCK1. Here, we made a series of UBR5 HECT domain truncation variants and, through pull-down assay, showed that the N-terminal lobe of the UBR5 HECT domain is largely responsible for interacting with PEPCK1. We mutated all three lysine residues thought to be acetylated in PEPCK1 but were surprised to observe no loss of binding to UBR5 HECT domain. Furthermore, two PEPCK1 truncation variants (74-622 aa and 10-560 aa) lacking these lysine residues were still able to bind with UBR5 and ubiquitinated in HEK293T cells. To discover the ubiquitination site(s) of PEPCK1, which is currently unknown, the Lys residues of PEPCK1 were mutated to Ala and the ubiquitination level of the PEPCK1 mutants was assessed. Results revealed at least two ubiquitination sites (Lys243 and Lys342), which represent the first time that ubiquitination sites of PEPCK1 have been identified. Our pull-down experiments further show that the lack of ubiquitination of PEPCK1 Lys243Ala and Lys342Ala mutants is not due to their binding to UBR5, which remained unchanged. Taken together, our work has provided new insights into UBR5 mediated ubiquitination of PEPCK1.
Concentration of Polyphenolic Compounds from Grape Seed by Nanofiltration Technology
Authors: Li Cunyu , Ma Yun , Li Hongyang , Peng Guoping 
Published: December 2018

Abstract
In order to evaluate the applicability of nanofiltration (NF) polyphenols determined by total phenolic compounds content with application of Folin method in grape seed extract, response surface analysis methodology was used to analyze the concentration process with the indices of membrane fouling and antioxidant activity. In addition to the influencing factors of molecular weight cut-off (MWCO) of NF membrane, procyanidin concentration and pH value, the evaluation index of procyanidin rejection was taken into account for the process optimization by Box-Behnken response surface method on the basis of single factor test. According to Box-Behnken central composite experiment design, the optimal conditions were obtained as follows: NF MWCO of 400 Da, 27.66 μg/mL procyanidins, and pH 5.20. The predicted rejection of procyanidins under the optimum conditions was 97.17% and the experimental value was 96.36 ± 0.87%, which was in accordance with the predicted value. The experimental value of total polyphenolic content (TPC) was 91.09 ± 0.46%. The antioxidant activity was increased about 2.24 times and the antioxidant activity was correlated with the procyanidin content. Moreover, it was easy to clean membrane fouling. The NF was an effective method for concentrating polyphenolic compounds from grape seed extracts without the loss of polyphenolic compounds. The agricultural product utilization was improved greatly and the power consumption was decreased by the NF technology.
Effect of Fiber-Optics Nonlinearities in Long Haul and Ultra-High Speed DWDM Optical Transmission Networks at 10, 40 and 100 Gb/s Ultra-High Speed Data Rates
Authors: Ali Farman , Khan Yousaf , Qureshi Shahryar Shafique , Ahmad Shabir , Waqas Muhammad 
Published: December 2018

Abstract
The impact of major nonlinearities in optical fiber such as SRR (Stimulated Raman Scattering) and Four Wave Maxing (FWM) in cascaded amplifier Dense Wavelength Division Multiplexing optical long reach and high speed data rate transmission scheme have been investigated at different data rates. Pulse walk off effect is considered for the purpose of calculating Stimulated Raman Scattering (SRS) nonlinear factor. Examination has been accomplished to assess signal to noise ratio thinking about the consolidated impact of SRS and FWM within the sight of amplified spontaneous emission noise to achieve minutest noise at altered data rates.
Investigation on Pointing Error in Multi-Beam Free Space Optical Communication System
Authors: Jayabarathan Jayson K. , Robinson S. 
Published: December 2018

Abstract
Free space optical (FSO) communication has fascinated a lot of attention for a variety of applications in telecommunication area. It is dream of every researcher and telecommunication society to make it a real alternative solution for the last mile problem, to replace fiber optics. FSO is much favored because of its low maintenance cost and deployment time. Pointing error is one of the main challenges in FSO communication system which affects its performance especially at high data links that leads to significant performance degradation. In this paper, the impact of pointing error for multi-beam Hybrid Wavelength Division Multiplexing (HWDM) FSO system is investigated. Then the effect of link distance and Bit Error Rate (BER) are estimated by accounting the pointing error and atmospheric attenuation. The effect of change of link distance is examined while changing the number of beams between the transmitter and receiver as well. In this attempt, the HWDM system is considered by combining eight Dense Wavelength Division Multiplexing (DWDM) channels and four Coarse Wavelength Division Multiplexing (CWDM) channels. In addition, the influences of BER and receiver sensitivity are analyzed for the proposed system by incorporating Erbium Doped Fiber Amplifier (EDFA) at the receiver end. The data rate 2.5 Gbps is considered for both CWDM and DWDM channels for investigation.