bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cooling‐Induced Order–Disorder Phase Transition in CsPbBr3 Nanocrystal Superlattices
Authors: Filippi Umberto , Toso Stefano , Zaffalon Matteo L. , Pianetti Andrea , Li Zhanzhao , Marras Sergio , Goldoni Luca , Meinardi Francesco , Brovelli Sergio , Baranov Dmitry , Manna Liberato 
Published: November 2024

AbstractPerovskite nanocrystal superlattices are being actively studied after reports have emerged on collective excitonic properties at cryogenic temperatures, where energetic disorder is minimized due to the frozen lattice vibrations. However, an important issue related to structural disorder of superlattices at low temperatures has received little attention to date. In this work, it is shown that CsPbBr3 nanocrystal superlattices undergo a reversible order–disorder transition upon cooling to 90 K. The transition consists of the loss of structural coherence, that is, increased nanocrystal misalignment, and contraction of the superlattices, as revealed by temperature‐dependent X‐ray diffraction, and is ascribed to the solidification of ligands (on the basis of Raman spectroscopy). Introducing shorter amines on the nanocrystal surface allows to mitigate these changes, improve order, and shorten interparticle distance. It is demonstrated that the low temperature phase of the short ligand‐capped nanocrystal superlattices is characterized by a strong exciton migration observable in the photoluminescence decay, which is due to the shrinkage of the inter‐nanocrystal distance.
An Oral PROTAC Targeting HPK1 Degradation Potentiates Anti‐Solid Tumor Immunity
Authors: Yao Yuejun , Wu Mingfei , Wang Yanfang , Liao Ziyan , Yang Yinxian , Liu Yun , Shi Jiaqi , Wu Wei , Wei Xinwei , Xu Jianchang , Guo Yugang , Dong Xiaowu , Che Jinxin , Wang Jinqiang , Gu Zhen 
Published: November 2024

AbstractHematopoietic progenitor pinase1 (HPK1) knockout has been identified as an efficient route to enhance anti‐tumor immune response. Here, this work develops an oral proteolysis targeting chimera (PROTAC) targeting HPK1 to efficiently and selectively degrade HPK1 to augment immunotherapeutic outcomes. In a postoperative tumor model of human cervical cancer in NSG mice, the orally‐administrated PROTAC can reach tumors, down‐regulate HPK1 levels in locally‐administrated CAR‐T cells, and promote their efficiency in inhibiting solid tumor recurrence, achieving 50% partial response (PR) and 50% complete response (CR). In addition, oral administration of PROTAC can amplify the suppression capability of the anti‐PD‐L1 antibody on the growth of CT26 solid tumors in BALB/c mice by promoting the infiltration of CD45‐positive immune cells from 0.7% to 1.5% and CD3‐positive T cells from 0.2% to 0.5% within the tumors.
Edge Electron Effect Induced High‐Entropy SEI for Durable Anode‐Free Sodium Batteries
Authors: Ge Junmin , Ma Cunshuang , Zhang Yaoyang , Ma Pei , Zhang Jiyu , Xie Zhengkun , Wen Longfei , Tang Guochuan , Wang Qingbao , Li Wenbin , Guo Xiaoniu , Guo Ying , Zhang Erjin , Zhang YongChao , Zhao Lingfei , Chen Weihua 
Published: November 2024

AbstractAnode‐free sodium metal batteries represent great promising as high‐energy‐density and resource‐rich electrochemical energy storage systems. However, the savage growth of sodium metal and continuous consumption hinder its stable capacity output. Herein, ordered flower‐edges of zinc on Al substrate can induce high‐entropy solid electrolyte interphase (SEI) to adjust sodium uniform deposition and extremely reduce electrolyte consumption with ultrahigh initial Coulombic efficiency (97.05%) for prolong batteries cycling life. Theoretical and experimental studies have demonstrated that the electron‐donating property and exposed edge sites between (100) and (101) facets in zinc flower enhance anion adsorption onto the inner Helmholtz plane accelerating its interface decomposition. Additionally, the ordered zinc edges serve as homogeneous‐nucleating template, leading to thin and inorganic‐rich SEI layer (18 nm, ZnF2, NaZn13, NaF, and Na2CO3) with high‐entropy discrete multicomponent distribution, so that fast and high‐flux Na ions transport field, thereby reducing the critical nucleation barrier and promoting sodium high density nucleation (7.36 × 1013 N cm−2) and pyknotic growth (3 mAh cm−2, 22 µm). The assembled anode‐free sodium batteries exhibit high stability (86%, 90 cycles) under ultrahigh cathode loading (32 mg cm−2). Moreover, the anode‐less single‐layer pouch batteries exhibit a durable capacity retention of 99% after 600 cycles.
Synthesis of High‐Surface‐Area Alumina using Carbon Templating and Liquid Phase Atomic Layer Deposition
Authors: Talebkeikhah Farzaneh , Lin Yu‐Cheng , Luterbacher Jeremy S. 
Published: November 2024

AbstractCertain metal oxides exhibit unique phases and associated properties that can generally only be accessed via high temperature treatments. However, high temperature processes usually lead to surface reconstruction and pore collapse, which reduces the active surface area. In this study, a novel method for accessing phases is demonstrated at high temperature while maintaining porosity by depositing thin oxide films onto a temperature stable activated carbon template. Subsequent annealing and calcination creates the phase of interest while maintaining the porous structure. Specifically, stoichiometrically limited liquid phase atomic layer deposition is used to deposit 6, 9, 12 and 15 layers of amorphous alumina, which, following high temperature treatment, led to a mixture of α and δ phases with surface areas of 186 and 146 m2 g−1 for 6 and 9 layers respectively. Pure α alumina can also be achieved with high surface areas of 76 and 45 m2 g−1 for 12 and 15 layers. Importantly, all the samples retained the porosity imparted by the carbon structure, with primarily meso and macro pores. Furthermore, different metal oxides are also deposited onto the activated carbon surface, including ZnO, TiO2, ZrO2, and Ga2O3 illustrating this templating concept can also be applied to different materials.
MXene−Graphene Oxide Heterostructured Films for Enhanced Metasurface Plasmonic Biosensing in Continuous Glucose Monitoring
Authors: Li Rui , Fan Hongli , Chen Youqian , Yin Shaoping , Liu Gang L. , Li Yanan , Huang Liping 
Published: November 2024

AbstractNon‐invasive biosensors have attracted attention for their potential to obtain continuous, real‐time physiological information through measurements of biochemical markers, such as one of the most important—glucose, in biological fluids. Although some optical sensing materials are used in non‐invasive devices for continuous glucose monitoring (CGM), surface or localized plasmon sensing material are seldom applied in CGM owing to modest sensitivity and bulk sensing apparatus. Herein, a metasurface (MGMSPR) biosensor based on the metasurface plasmon resonance chip modified with heterostructured Ti3C2 MXene−Graphene oxide (MG) is reported, which potentially enables ultra‐sensitive glucose detection. The sensor consists of a dual‐channel microfluidic device integrated with silver mirror enhanced MGMSPR chips. Not only does it promote the entry of glucose oxidase (GOD) into the internal pores and enhance the stable fixation of GOD in the membrane, but also the integration of MG material provides a high specific surface area and unique electronic properties, thereby significantly enhancing the sensitivity of the MGMSPR sensor. The detection limit of MGMSPR biosensor is 106.8 µM. This pioneering approach opens new avenues for monitoring physiological parameters and process analytical technology on an optical platform, providing continuous health monitoring and production process control through optical sensors.
Regulating the Perovskite Crystallization Dynamics Via Dual Modulation Strategy for Performance Enhancement of Perovskite Solar Cells
Authors: Dong Hang , Qu Jinsong , Yue Xin , Zhao Yue , Wang Weidong , Chen Dazheng , Zhu Weidong , Xi He , Zhou Long , Zhang Jincheng , Lu Gang , Zhang Chunfu , Hao Yue 
Published: November 2024

AbstractA novel cooperative regulatory strategy is proposed in this work to optimize the crystallization dynamics of Formamidinium (FA)‐based perovskite materials, which is achieved by meticulously incorporating the organic molecule guanidinium (GA+) and the high boiling point organic solvents N‐Methyl‐2‐Pyrrolidone (NMP) into the perovskite precursor solution synergistically. This findings indicated that the GA+ doping strategy (G‐DS) is toward to inhibits the formation of α‐phase perovskite crystals owing to its larger ionic radius, thereby promoting the formation of perovskite films with enlarged grain size. Simultaneously, the NMP‐doping strategy (N‐DS) has assisted controllable crystallization dynamics in as‐cast films by optimizing nucleation density and crystal growth rate through a delayed supersaturated environment induced re‐dissolution function. Briefly, it can assume that the crystallization dynamics dual modulation strategy enables the realization of high‐quality perovskite film with micro‐meter sized perovskite grain, appropriate internal strain and a compact, dense surface texture. The optimized films therefore exhibits powerful exciton separation energy, suppressed charge carrier recombination and reduces series resistance, leading to a remarkable champion power conversion efficiency (PCE) of 25.38% and exceptional reliability, retaining 93.09% of their initial PCE after storage the unencapsulated devices in a moisture‐rich environment for 2160 h.
Treatment‐Free Remissions in Children With Chronic Myeloid Leukemia (CML): A Prospective Study From the Tata Memorial Hospital (TMH) Pediatric CML (pCML) Cohort
Authors: Roy Moulik Nirmalya , Keerthivasagam Swaminathan , Chatterjee Gaurav , Agiwale Jayesh , Rane Pallavi , Dhamne Chetan , Chichra Akanksha , Srinivasan Shyam , Mohanty Purvi , Jain Hemani , Shetty Dhanlaxmi , Rajpal Sweta , Tembhare Prashant , Patkar Nikhil , Narula Gaurav , Subramanian Papagudi G. , Banavali Shripad 
Published: November 2024

ABSTRACTPediatric chronic myeloid leukemia (pCML) is a rare childhood malignancy, representing 2%–3% of all childhood leukemia. Tyrosine kinase inhibitors (TKIs) have greatly improved survival but pose challenges due to their long‐term effects on growth and bone health in children. We prospectively studied treatment‐free remission (TFR) in 45 children with pCML in chronic phase on imatinib. Eligibility criteria were as per current NCCN guidelines, with a less stringent qPCR monitoring scheduled every 3 months. TFR was successful in 71.1% (32 out of 45) of patients after a median follow‐up of 25 (range: 6–42) months. The TFR rates at 12 and 24 months were 70% and 66%, respectively. Children under 5 years had a TFR rate of 88.9%, compared to 61.8% in those over 5 years (p = 0.18). Eleven of the 13 patients who lost MMR did so within 6 months of discontinuation. The cumulative incidence of loss in MMR at 6, 12, and 24 months was 26.4%, 27%, and 33%, respectively. Ten out of 13 (76.9%) patients with discontinuation failure (DF) regained MMR within 3 (2–20) months of restarting imatinib. A significant correlation was found between higher T‐regulatory cell levels at baseline and DF (p = 0.005). More than half patients showed improved bone mineral density after 2 years of TFR. Our findings suggest that high TFR rates can be attained in pCML, with added benefits for bone health. Less frequent molecular monitoring was not associated with adverse outcomes and there seems to be a role of the immune system in sustaining TFR. The study is registered in the Clinical Trials Registry‐India (CTRI/2020/11/029199).
Chronic Catatonia in an Individual With a De Novo Missense SHANK1 Variant
Authors: Dahlberg Paige M. , Harris Holly K. , Lloyd Holder J. 
Published: November 2024

ABSTRACTSHANK1 encodes a scaffolding protein of the SHANK family that includes SHANK1, SHANK2 and SHANK3. All of the SHANK proteins are enriched at the post‐synaptic density of excitatory synapses. Here, we present an 11‐year‐old boy with a history of developmental delays and no family history of psychiatric disorders who developed catatonia. MRI of his brain and spine were negative as was a workup for autoimmune encephalitis. The proband's genetic testing revealed a de novo heterozygous SHANK1 missense variant. Although catatonia has been reported previously in individuals with SHANK3 loss‐of‐function mutations, this is the first time catatonia has been described in an individual with a SHANK1 variant.
Selective Nonenzymatic Formation of Biologically Common RNA Hairpins
Authors: Wu Long‐Fei , Zhang Junting , Cornwell‐Arquitt Robert , Hendrix David A. , Radakovic Aleksandar , Szostak Jack W. 
Published: November 2024

AbstractThe prebiotic formation of RNA building blocks is well‐supported experimentally, yet the emergence of sequence‐ and structure‐specific RNA oligomers is generally attributed to biological selection via Darwinian evolution rather than prebiotic chemical selectivity. In this study, we used deep sequencing to investigate the partitioning of randomized RNA overhangs into ligated products by either splinted ligation or loop‐closing ligation. Comprehensive sequence‐reactivity profiles revealed that loop‐closing ligation preferentially yields hairpin structures with loop sequences UNNG, CNNG, and GNNA (where N represents A, C, G, or U) under competing conditions. In contrast, splinted ligation products tended to be GC rich. Notably, the overhang sequences that preferentially partition to loop‐closing ligation significantly overlap with the most common biological tetraloops, whereas the overhangs favoring splinted ligation exhibit an inverse correlation with biological tetraloops. Applying these sequence rules enables the high‐efficiency assembly of functional ribozymes from short RNAs without template inhibition. Our findings suggest that the RNA tetraloop structures that are common in biology may have been predisposed and prevalent in the prebiotic pool of RNAs, prior to the advent of Darwinian evolution. We suggest that the one‐step prebiotic chemical process of loop‐closing ligation could have favored the emergence of the first RNA functions.
High‐Efficiency Trifluoromethyl‐Methionine Incorporation into Cyclophilin A by Cell‐Free Synthesis for 19F NMR Studies
Authors: Zhu Wenkai , Monnie Christina M. , Kitoka Kristīne , Gronenborn Angela M. 
Published: November 2024

AbstractFluorine‐19 NMR spectroscopy has emerged as a powerful tool for studying protein structure, dynamics, and interactions. Of particular interest is the exploitation of trifluoromethyl (tfm) groups, given their high sensitivity and superior transverse relaxation properties, compared to single fluorine atoms. However, biosynthetic incorporation of tfm‐bearing amino acids remains challenging due to cytotoxicity and incompatibility with natural tRNA synthetases. Here, we report on overcoming this challenge using cell‐free synthesis, incorporating trifluoromethyl‐methionine (tfmM) into the protein Cyclophilin A (CypA) with remarkably high efficiency, impossible via biosynthetic means. Importantly, we demonstrate that tfmM CypA binds a native substrate, the N‐terminal domain of HIV‐1 capsid protein (HIV‐1 CA‐NTD), and retains peptidyl prolyl cis/trans isomerase activity. It also binds the peptide inhibitor Cyclosporine A (CsA) with the same affinity as non‐labeled, wild‐type CypA. Furthermore, we show that 19F isotope shifts and 19F solvent paramagnetic relaxation enhancements (PREs) provide valuable structural information on surface exposure. Taken together, our study illustrates that tfmM can be readily incorporated into proteins at very high levels by cell‐free synthesis without disturbing protein structure and function, significantly expanding the scope of 19F NMR spectroscopy for studying protein structure and dynamics.
A C156 Molecular Nanocarbon: Planar/Rippled Nanosheets Hybridization
Authors: Fu Ruihua , Chen Xingyu , Qiu Fei , Liu Xinyue , Xia Jianlong , Zhang Lei 
Published: November 2024

AbstractA novel hybrid nanocarbon consisting of one rippled and two planar nanosheets has been synthesized and characterized. Two meso pairs of [5]helicenes are formed along the long molecular axis of the hybrid to connect rippled and planar subunits, leading to a stable conformation. It is shown that the hybrid possesses the individual electronic properties of the rippled and planar subunits. Compared to the rippled subunit, such hybrid has a better geometric match to C60 and complexes with C60 in a 1 : 1 stoichiometry, with the association constant on the order of 105 M−1. The hybrid displays unusual anti‐Kasha fluorescence emission. The transient absorption spectroscopy revealed that the singlet fission (SF) from higher level singlet excited states (Sn) is operative in the film of the hybrid.
Transitioning Room‐Temperature Phosphorescence from Solid States to Aqueous Phases via a Cyclic Peptide‐Based Supramolecular Scaffold
Authors: Feng Ruicong , Yan Xianjia , Sang Yufeng , Liu Xindi , Luo Zhi , Xie Zhenhua , Ke Yubin , Song Qiao 
Published: November 2024

AbstractAqueous room‐temperature phosphorescence (RTP) materials have garnered considerable attention for their significant potential across various applications such as bioimaging, sensing, and encryption. However, establishing a universally applicable method for achieving aqueous RTP remains a substantial challenge. Herein, we present a versatile supramolecular strategy to transition RTP from solid states to aqueous phases. By leveraging a cyclic peptide‐based supramolecular scaffold, we have developed a noncovalent approach to molecularly disperse diverse organic phosphors within its rigid hydrophobic microdomain in water, yielding a series of aqueous RTP materials. Moreover, high‐performance supramolecular phosphorescence resonance energy transfer (PRET) systems have been constructed. Through the facile co‐assembly of a fluorescent acceptor with the existing RTP system, these PRET systems exhibit high energy transfer efficiencies (>80 %), red‐shifted afterglow emission (520–790 nm), ultralarge Stokes shifts (up to 450 nm), and improved photoluminescence quantum yields (6.1–30.7 %). This study not only provides a general strategy for constructing aqueous RTP materials from existing phosphors, but also facilitates the creation of PRET systems featuring color‐tunable afterglow emission.
A Promising Tropical Medicinal Plant: Taiwan as the Production Hub of Japan's Coca Empire**
Authors: Lu Shao‐li 
Published: November 2024

AbstractBefore World War II, Taiwan became the second‐largest coca leaf production base in Asia, second only to Java, contributing to Japan's position as the world's largest exporter of cocaine. While Japan's opium empire has been the subject of extensive academic inquiry, its coca empire has received far less attention. This article explores Taiwan's role in Japan's dual empire of opium and coca, focusing on the environmental and historical factors that enabled the island to rapidly expand coca production. It finds that, in addition to Taiwan's favorable climate for coca cultivation, the island's long‐established tea industry provided mature techniques for harvesting and drying the coca leaves. Furthermore, the sugar company supplied the necessary equipment and capital for the extraction of cocaine, becoming a key resource in the industry's development. Learning from the limitations of the opium monopoly—where raw materials were increasingly constrained by international markets—the colonial government sought to promote self‐sufficiency in coca production. This strategy not only ensured a stable supply of raw materials but also allowed the coca industry to balance for the declining incomes from opium as international controls tightened. From all angles, the coca industry met Japan's expectations as a “promising drug.”
The British Missionaries’ Attempts to Identify Chinese Medicine**
Authors: Chang Che‐chia 
Published: November 2024

AbstractThe Western world has a profound historical engagement with medicinal resources originating from China. Following the Opium War, missionaries were granted access to China and established residence there. Motivated by clinical necessities and the inquisitiveness of the Western scientific community, these missionaries meticulously documented the medicinal resources available in China, endeavoring to incorporate this knowledge into Western pharmacology. Among the various reports produced in multiple languages, the contributions in English have emerged as particularly influential. This article seeks to analyze the information‐gathering processes within the missionary network and among other naturalists, commencing with Robert Morrison, the inaugural compiler of the English‐Chinese dictionary, and extending to Stephen A. Hunter, who collaborated with Chinese officials to develop a complete translation for pharmaceutical nomenclature.
How therapists take stock of therapeutic progress at the end of initial assessment
Authors: Bradshaw Thomas , Couteur Amanda Le , Oxlad Melissa 
Published: November 2024

AbstractBackground and ObjectiveCognitive behavioural therapy has a significant attrition rate, yet little is known about how therapists work to encourage clients to continue in therapy. This study aimed to understand how therapists might encourage clients to continue therapy attendance.MethodUsing conversation analysis, we analysed regularities that occurred between the information gathering phase and rebooking in a corpus of initial psychology interviews.ResultsWe describe a commonly occurring ‘stock‐taking’ activity wherein therapists discussed progress through a set of interrelated concerns (clients' problems, problem causes, problem interventions, and positive outcomes). Both clients and therapists oriented towards stock‐taking being enacted in service of encouraging clients to continue with therapy.ConclusionThese findings offer practical guidance about one way that therapists might encourage clients to continue therapy. We also discuss implications for future research and clinical practice.
Innovative Endodontic Management of Pulp Canal Obliteration in Mandibular Incisors Using a Static Navigation System: A Case Report
Authors: MahjourianQomi Reza , Aminsobhani Mohsen , Assadian Hadi , Adnaninia Seyed Taha 
Published: November 2024

ABSTRACTThe present case report aims to describe the successful management of pulp canal obliteration (PCO) in mandibular incisors using static‐guided endodontics. A healthy 74‐year‐old man was referred by a prosthodontist for root canal treatment on teeth #31, #32, and #41. Periapical radiographs revealed the presence of periapical lesions as well as PCOs in teeth #31 and #41. After cone‐beam computed tomography (CBCT) evaluation, guided endodontics was selected as the treatment approach. The intraoral scan of the lower jaw and CBCT datasets were aligned and processed through image processing software to design and create a 3D‐printed guide. A virtual drill was superimposed on the scans to ensure proper access to the identified root canals. Finally, the virtually designed guide was printed using a 3D printer and accurately positioned on the teeth. The access cavities were prepared using a Munce Discovery bur. After detecting the canals, the working length was determined. Root canal preparation was performed using rotary files up to F2, followed by obturation with gutta‐percha and a bioceramic sealer. After a six‐month follow‐up, the teeth remained completely asymptomatic and functional, and the periapical radiograph showed a normal periodontal ligament space, demonstrating the effectiveness of the treatment. These results indicate that static‐guided endodontics can be an effective and predictable approach for managing PCO in mandibular incisors with some consideration. Furthermore, these results highlight the clinical implications of this approach, particularly in elderly patients or teeth with severe obliterations.