bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of liraglutide in Indian adolescents with obesity
Authors: Kochar I. S. , Sethi A. 
Published: December 2018

SummaryAimThe aim of this study was to evaluate the efficacy and safety of liraglutide in adolescents with obesity.Materials and methodsPatients (n = 41) received injection liraglutide for at least 12 weeks and their pre‐baseline and post‐baseline characteristics were recorded and analysed. The key parameters analysed were weight, height, body mass index (BMI), fasting insulin and sugar, 1 h insulin and glucose, 2 h insulin and glucose, HbA1c, cholesterol, triglycerides, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, thyroid stimulating hormone and bone.ResultsThere was a significant decrease (p < 0.001) in body weight, BMI, fasting, 1 h post‐glucose tolerance and 2 h glucose tolerance. The changes from baseline to the end of study were for body weight − 6.5 ± 4.2 kg and BMI –2.35 ± 1.30 kg m−2. Systolic blood pressure decreased from 119.25 ± 12.50 to 114.53 ± 9.53 mmHg and diastolic blood pressure from 70.69 ± 14.52 to 70.82 ± 8.85 mmHg. Liver enzymes had improved from 34.36 ± 12.23 (serum glutamic oxaloacetic transaminase), 38.08 ± 21.02 (serum glutamic pyruvic transaminase) to 33.52 ± 11.23 (p = 0.03) and 33.99 ± 13.16 (p = 0.01), respectively. Cholesterol and triglyceride had improved from 152.46 ± 24.74 and 124.41 ± 33.27 to 151.71 ± 23.46 (p = 0.14) and 120.76 ± 26.22 (p = 0.009), respectively.ConclusionIn conclusion, treatment with liraglutide in adolescents with obesity offers an efficacious and safe alternative to patients who are not responding to other available modalities.
Comparable on‐therapy mortality and supportive care requirements in Black and White patients following initial induction for pediatric acute myeloid leukemia
Authors: Li Yimei , Newton Joanna G. , Getz Kelly D. , Huang Yuan‐Shung , Seif Alix E. , Fisher Brian T. , Aplenc Richard , Winestone Lena E. 
Published: December 2018

AbstractBackgroundBlack patients with acute myeloid leukemia (AML) are more likely to present with high acuity and consequently experience higher rates of induction mortality than white patients. Given the consistently identified racial disparities in overall survival (OS) among patients with AML, we aimed to evaluate whether there were sustained on‐therapy racial differences in inpatient mortality, intensive care unit (ICU) requirements, or supportive care beyond initial induction.ProcedureWithin a retrospective cohort of 1239 children diagnosed with AML between 2004 and 2014 in the Pediatric Health Information System (PHIS) database who survived their initial course of induction chemotherapy, we compared on‐therapy inpatient mortality, ICU‐level care requirements, treatment course duration, cumulative length of hospital stay (LOS), and resource utilization after induction I by race.ResultsOver the period from the start of induction II through completion of frontline chemotherapy, there were no significant differences in mortality (adjusted odds ratios [OR], 1.01; 95% confidence intervals [CI], 0.41–2.48), ICU‐level care requirements (adjusted OR, 0.93; 95% CI, 0.69–1.26), LOS (adjusted mean difference, 3.2 days; 95% CI, −2.3–9.6), or supportive care resource utilization for black patients relative to white patients. Course‐specific analyses also demonstrated no differences by race.ConclusionAlthough black patients have higher acuity at presentation and higher induction mortality, such disparities do not persist over subsequent frontline chemotherapy treatment. This finding allows interventions aimed at reducing disparities to be directed at presentation and induction.
Maternal and neonatal outcomes after exposure to ADHD medication during pregnancy: A systematic review and meta‐analysis
Authors: Jiang Hai‐yin , Zhang Xue , Jiang Chun‐ming , Fu Hai‐bin 
Published: December 2018

AbstractPurposeAttention‐deficit/hyperactivity disorder (ADHD) medications are used by increasing numbers of reproductive‐age women. The safety of these medications during pregnancy has not been well described.MethodsA systematic review and meta‐analysis was performed to evaluate the adverse maternal and neonatal outcomes associated with exposure to ADHD medication during pregnancy. The PubMed and Embase databases were searched to identify potential studies for inclusion.ResultsEight cohort studies that estimated adverse maternal or neonatal outcomes associated with exposure to ADHD medication during pregnancy were included. Exposure to ADHD medication was associated with an increased risk of neonatal intensive care unit (NICU) admission compared with no exposure at any time (risk ratio (RR) 1.88; 95% confidence interval (CI), 1.7‐2.08) and compared with women with exposure either before or after pregnancy (RR 1.38; 95% CI, 1.23‐1.54; P < 0.001). Exposure to methylphenidate (MPH) was marginally associated with an increased risk for cardiac malformation (RR 1.27; 95% CI, 0.99‐1.63; P = 0.065) compared with no exposure. However, exposure to ADHD medication was not associated with an increased risk for other adverse maternal or neonatal outcomes. This analysis was limited by the small number of studies included and the limited adjustments for the possible confounders in the studies.ConclusionsExposure to ADHD medication during pregnancy does not appear to be associated with adverse maternal or neonatal outcomes. Given the few studies included, further larger, prospective studies that control for important confounders are needed to verify our findings.
Solar cell efficiency tables (Version 53)
Authors: Green Martin A. , Hishikawa Yoshihiro , Dunlop Ewan D. , Levi Dean H. , Hohl‐Ebinger Jochen , Yoshita Masahiro , Ho‐Baillie Anita W.Y. 
Published: December 2018

AbstractConsolidated tables showing an extensive listing of the highest independently confirmed efficiencies for solar cells and modules are presented. Guidelines for inclusion of results into these tables are outlined and new entries since July 2018 are reviewed.
Absolute Quantification of All Identified Plasma Proteins from SWATH Data for Biomarker Discovery
Authors: Rice Shawn J. , Liu Xin , Zhang Jianhong , Belani Chandra P. 
Published: December 2018

AbstractThe current state of proteomics requires a choice between targeted and global discovery methods. A method, that combines targeted and data‐independent acquisition for absolute quantification of all identified plasma proteins, in a single sequential window acquisition of all theoretical fragment ions (SWATH) acquisition run, using a panel of spike‐in standards (SIS), is established and optimized. The absolute quantification (AQ) of SWATH and multiple‐reaction monitoring‐high resolution (MRM‐HR) acquisition methods are compared using the 100 protein PlasmaDive SIS panel spiked into non‐depleted human plasma. SWATH provides equivalent quantification and differentially abundant protein profiles as MRM‐HR. Absolute quantities of the SIS peptides from the SWATH data are used to estimate the absolute quantities (eAQ) for all the proteins in the run. The eAQ values provide similar quantification and differentially abundant protein profiles as AQ and protein area (PA) values. As a proof‐of‐concept, the eAQ method is applied to 12 plasma samples from six non‐small cell lung cancer (NSCLC) patients and the performance of eAQ values versus peak area quantification is evaluated. There is a strong correlation between AQ and peak area ratios producing significant overlap of differentially abundant proteins. This eAQ method can provide quantitative data equivalent to AQ or peak area values.
Concise Review: Towards the Clinical Translation of Induced Pluripotent Stem Cell-Derived Blood Cells—Ready for Take-Off
Authors: Haake Kathrin , Ackermann Mania , Lachmann Nico 
Published: December 2018

AbstractSince their discovery in 2006, induced pluripotent stem cells (iPSCs) have opened up a world of possibilities for regenerative medicine and novel cell-based therapeutics. Now, over a decade later, robust reprogramming and expansion and differentiation protocols have been developed, and iPSC-derived cells have been used in a wide variety of small and large animal models to treat many different diseases. Furthermore, the first iPSC derivatives are on their way into clinical trials. In this line, (i) GMP-compliant generation, cultivation, and differentiation, (ii) preclinical efficacy and safety, as well as (iii) ethical and regulatory compliance of stem cell research represent important aspects that need to be evaluated for proper clinical translation of iPSCs and their derivatives. In this review article, we provide an overview of the current advances and challenges of the clinical translation of iPSC-derived blood cells and highlight the most pressing problems that have to be overcome in the next years. Stem Cells Translational Medicine 2019;8:332–339
Concise Review: Periodontal Tissue Regeneration Using Stem Cells: Strategies and Translational Considerations
Authors: Xu Xin-Yue , Li Xuan , Wang Jia , He Xiao-Tao , Sun Hai-Hua , Chen Fa-Ming 
Published: December 2018

Abstract
Periodontitis is a widespread disease characterized by inflammation-induced progressive damage to the tooth-supporting structures until tooth loss occurs. The regeneration of lost/damaged support tissue in the periodontium, including the alveolar bone, periodontal ligament, and cementum, is an ambitious purpose of periodontal regenerative therapy and might effectively reduce periodontitis-caused tooth loss. The use of stem cells for periodontal regeneration is a hot field in translational research and an emerging potential treatment for periodontitis. This concise review summarizes the regenerative approaches using either culture-expanded or host-mobilized stem cells that are currently being investigated in the laboratory and with preclinical models for periodontal tissue regeneration and highlights the most recent evidence supporting their translational potential toward a widespread use in the clinic for combating highly prevalent periodontal disease. We conclude that in addition to in vitro cell-biomaterial design and transplantation, the engineering of biomaterial devices to encourage the innate regenerative capabilities of the periodontium warrants further investigation. In comparison to cell-based therapies, the use of biomaterials is comparatively simple and sufficiently reliable to support high levels of endogenous tissue regeneration. Thus, endogenous regenerative technology is a more economical and effective as well as safer method for the treatment of clinical patients. Stem Cells Translational Medicine 2019;8:392–403
Developing Egyptian water quality index for drainage water reuse in agriculture
Authors: El‐Sayed A. , Shaban M. 
Published: December 2018

AbstractIn Egypt, water quality (WQ) is an ordinary activity. However, the calculation of a tailor‐made Egyptian WQ index is not. Therefore, this research attempts to develop an index for the agricultural drainage water (EG‐DWQI) that can be reused for irrigation based on collected WQ data measured monthly from August 2000 to July 2015. The development of the EG‐DWQI was carried out in four main steps, namely, parameters selection, parameter transformation to a common scale, assignment of parameters weights, and aggregation of subindices to produce a final index score. In its final form, the index can be easily estimated using a set of rating curves and their corresponding equations that were statistically tested and proved to be verified. The developed index was successfully employed to delineate the drainage WQ status that can be reused for irrigation in the Nile Delta of Egypt as benchmarking for future comparisons. The EG‐DWQI is proved to be easy, fast, and does not entail complex mathematics and can be easily managed by means of a spreadsheet.Practitioner points

This research develops a tailor made water quality index for assessing agricultural drainage water that can be re‐used for irrigation.

Then, the developed index was successfully employed to delineate the water quality in the main drains located in the Nile Delta of Egypt as benchmarking for future comparisons.

The application of the index is proved to be easy, fast and does not entail complicated mathematics especially with the new computer facilities.
Loss-of-function of sox3 causes follicle development retardation and reduces fecundity in zebrafish
Authors: Hong Qiang , Li Cong , Ying Ruhong , Lin Heming , Li Jingqiu , Zhao Yu , Cheng Hanhua , Zhou Rongjia 
Published: December 2018

AbstractFolliculogenesis is essential for production of female gametes in vertebrates. However, the molecular mechanisms underlying follicle development, particularly apoptosis regulation in ovary, remain elusive. Here, we generated sox3 knockout zebrafish lines using CRISPR/Cas9. sox3 knockout led to follicle development retardation and a reduced fecundity in females. Comparative analysis of transcriptome between sox3−/− and wild-type ovaries revealed that Sox3 was involved in pathways of ovarian steroidogenesis and apoptosis. Knockout of sox3 promoted follicle apoptosis and obvious apoptosis signals were detected in somatic cells of stages III and IV follicles of sox3−/− ovaries. Moreover, Sox3 can bind to and activate the promoter of cyp19a1a. Up-regulation of Cyp19a1a expression promoted 17β-estradiol synthesis, which inhibited apoptosis in follicle development. Thus, Sox3 functions as a regulator of Cyp19a1a expression, via 17β-E2 linking apoptosis suppression, which is implicated in improving female fecundity.
Level of Service Analysis for Metro Station with Transit Cooperative Research Program (TCRP) Manual: A Case Study—Shohada Station in Iran
Authors: Azadpeyma Arash , Kashi Ehsan 
Published: December 2018

Abstract
One of the main infrastructures in rail transportation is metro station. Obviously, analyzing and improving the capacity of the stations will ultimately lead to improved performance of the overall network. The capacity of metro station is the ability of the station and its associated spaces to create safety and comfort for the number of passengers expected to use the station. In this research, volume of passengers in the Shohada Square metro station has been used and simulated using VISSIM software. By the results of the simulation and regarding TCRP manual, six scenarios were analyzed in this research and different conditions were evaluated. Two main solutions for improving the performance of station were considered. It shows that the decision to remove the manual ticket purchase location will result in a 43% improvement in the performance of control space section and the approach to reducing the headway of trains from 240 s to 180 s will increase the amount of accessible space for each pedestrian in the platform to 35%. The method presented in this study can be used to evaluate and analyze other metro stations and even other transportation network stations.
Cortical expression of AMPA receptors during postnatal development in a genetic model of absence epilepsy
Authors: Adotevi Nadia Kafui , Leitch Beulah 
Published: December 2018

AbstractChildhood absence epilepsy has been associated with poor academic performance, behavioural difficulties, as well as increased risk of physical injury in some affected children. The frequent episodes of ‘absence’ arise from corticothalamocortical network dysfunction, with multifactorial mechanisms potentially involved in genetically different patients. Aberrations in glutamatergic neurotransmission has been implicated in some seizure models, and we have recently reported that reduced cortical AMPA receptor (AMPAR) expression (predominantly GluA4‐ containing AMPARs) in parvalbumin‐containing (PV+) inhibitory interneurons, could underlie seizure generation in the stargazer mutant mouse. In the present study, we investigate AMPA receptor subunit changes occurring during postnatal development in the stargazer mouse, to determine when these changes occur relative to seizure onset and thus could be contributory to seizure generation. Using quantitative western blotting, we analysed the expression of AMPAR GluA1‐4 subunits in the somatosensory cortex at three critical time points; two before seizure onset (postnatal days (PN) 7–9 and 13–15), and one at seizure onset (PN17–18) in stargazers. We report that compared to their non‐epileptic littermates, in the stargazer somatosensory cortex, there was a significant reduction in expression of AMPARs containing GluA1, 3 and 4 subunits prior to seizure onset, whereas reduction in expression of GluA2‐AMPARs appears to be a post‐seizure event. Thus, while loss of GluA4‐containing AMPARs (likely GluA1/4 and GluA3/4) may be linked to seizure induction, the loss of GluA2‐containing AMPARs is a secondary post‐seizure mechanism, which is most likely involved in seizure maintenance.
Homosexuality, Witchcraft, and Power: the Politics of Ressentiment in Cameroon
Authors: Roxburgh Shelagh 
Published: December 2018

Abstract:In this study I hope to deconstruct dominant and popular homophobic discourses in Cameroon to offer a deeper analysis of the common association made between homosexuality, witchcraft, and cults. Through a closer engagement with rumors that suggest homosexuality, witches, and cults are working collectively and covertly to destroy Cameroonian society important issues of power, morality, and inequality emerge, providing a more complex understanding of homophobic violence. I argue that in order to address homophobic concerns in Cameroon, activists must contend with the complexity of epistemological differences and speak to the root causes of an emerging ressentiment.
RE-EVALUATING THE CREDIBILITY OF EYEWITNESS TESTIMONY: THE MISINFORMATION EFFECT AND THE OVERCRITICAL JUROR
Authors: Puddifoot Katherine 
Published: December 2018

ABSTRACTEyewitnesses are susceptible to recollecting that they experienced an event in a way that is consistent with false information provided to them after the event. The effect is commonly called the misinformation effect. Because jurors tend to find eyewitness testimony compelling and persuasive, it is argued that jurors are likely to give inappropriate credence to eyewitness testimony, judging it to be reliable when it is not. It is argued that jurors should be informed about psychological findings on the misinformation effect, to ensure that they lower the credence that they give to eyewitness testimony to reflect the unreliability of human memory that is demonstrated by the effect. Here I present a new argument, the overcritical juror argument, to support the conclusion that eyewitnesses are likely to make inappropriate credence assignments to eyewitness testimony. Whereas previously authors have argued that jurors will tend to give too much credence to eyewitness testimony, I identify circumstances in which jurors will give too little credence to some pieces of testimony. In my view jurors should be informed by psychological findings relating to the misinformation effect to ensure that they do not lower the credence that they give to eyewitness testimony when they should not.
Organizational antecedents to designing a comprehensive complaint management system
Authors: S.Phabmixay Chanthaly , Rodríguez-Escudero Ana I , Rodríguez-Pinto Javier 
Published: December 2018

AbstractThe literature highlights two main approaches to designing an effective complaint management system: the mechanistic and the organic. The mechanistic approach emphasizes the establishment of guidelines for the correct processing, attention and resolution of complaints received. In contrast, the organic approach relies on creating a supportive internal environment for correct customer attention, made possible through training and empowering employees responsible for complaint management and by promoting extra-role behaviour among them. The present research aims to study the antecedents of adopting these two approaches. From a strategic perspective, we analyse the influence of organizational culture variables (the extent to which the firm is customer and innovation oriented) and the nature of the objectives pursued by complaint handling (defensive vs. improvement objectives). The proposed model is tested on a sample of 140 manufacturing firms. Findings indicate these antecedents shape the complaint management system in a diverse and significant manner.
New leaf-mine fossil from the Geumgwangdong Formation, Pohang Basin, South Korea, associates pygmy moths (Lepidoptera, Nepticulidae) with beech trees (Fagaceae,Fagus) in the Miocene
Authors: Sohn Jae-Cheon , Doorenweerd Camiel , Nam Kye Soo , Choi Sei-Woong 
Published: December 2018

AbstractA nepticulid leaf-mine ichnofossil,Stigmellites janggiSohn and Nam, n. ichnosp., is described on the basis of a fossil leaf ofFagusfrom the early Miocene Geumgwangdong Formation in Pohang Basin. This mine trace is characterized by a linear-blotch type with a clear centric frass trail composed of closely and randomly dispersed pellets filling the mine width in the early stage. We found traces of a possible egg case and an exit slit from the leaf. These features are most consistent with those produced by members of Nepticulidae. Our record demonstrates for the first time the trophic association of Nepticulidae withFagusin the Miocene and suggests the persistence of a long-term association between the insect family and the plant genus from the Miocene to the present. Other Nepticulidae leaf mines in the Miocene and leaf-mine fossils from the Geumgwangdong Formation are briefly reviewed.UUID:http://zoobank.org/fff951f6-ca82-4cca-a274-863e0d91acaa
ON THE STANDARD TWIST OF THE -FUNCTIONS OF HALF-INTEGRAL WEIGHT CUSP FORMS
Authors: KACZOROWSKI JERZY , PERELLI ALBERTO 
Published: December 2018

The standard twist$F(s,\unicode[STIX]{x1D6FC})$of$L$-functions$F(s)$in the Selberg class has several interesting properties and plays a central role in the Selberg class theory. It is therefore natural to study its finer analytic properties, for example the functional equation. Here we deal with a special case, where$F(s)$satisfies a functional equation with the same$\unicode[STIX]{x1D6E4}$-factor of the$L$-functions associated with the cusp forms of half-integral weight; for simplicity we present our results directly for such$L$-functions. We show that the standard twist$F(s,\unicode[STIX]{x1D6FC})$satisfies a functional equation reflecting$s$to$1-s$, whose shape is not far from a Riemann-type functional equation of degree 2 and may be regarded as a degree 2 analog of the Hurwitz–Lerch functional equation. We also deduce some results on the growth on vertical strips and on the distribution of zeros of$F(s,\unicode[STIX]{x1D6FC})$.