bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘WhatsApp®’ening in nephrology training
Authors: Jhaveri Kenar D , Pascarelli Briana , Hasan Alia , Kozikowski Andrzej , Fishbane Steven , Pekmezaris Renee 
Published: March 2019

Abstract

Background
Teaching methods in most residency and fellowship programs have not yet addressed the challenges of rapid dissemination of new scientific information. Our Northwell nephrology fellowship program used the smartphone application WhatsApp® to facilitate nephrology education. A qualitative study was conducted to explore perceptions of nephrology fellows and faculty using WhatsApp® as a teaching tool.

Methods
A WhatsApp® messenger group called ‘Northwell Renal Forum’ was created in 2018, which included all eight fellows and seven selected faculty members. Multiple choice questions on various nephrology topics were posted, about one to two per week. Fellows responded at their leisure. After 7 months, data were analyzed following two 1-h focus groups (one for faculty and one for fellows). Focus groups were moderated by two qualitative researchers, unknown to the participants, who asked open-ended questions about the WhatsApp® learning approach.

Results
Faculty feedback was generally positive. Three major themes arose: control over learning material, comfort being fostered between faculty and fellows and faculty perceptions of fellows. The fellows also reported an overall positive experience. Control and comfort were themes again identified in this focus group. Fellows reported feeling control over which faculty member was in the group and when to respond to questions. Fellows also felt comfort from learning without pressure. Variety was the third theme that arose.

Conclusion
Focus group evaluations elucidated the strengths of using WhatsApp®, and the overall positive experience of both faculty and fellows. This inexpensive and easy-to-use tool can augment the learning of nephrology during fellowship.
The effectiveness of supplemental vibrational force on enhancing orthodontic treatment. A systematic review
Authors: Lyu Chunxiao , Zhang Li , Zou Shujuan 
Published: March 2019

SummaryBackground and objectivesThe results from the literature regarding the influence of supplemental vibrational forces (SVFs) on orthodontic treatment are controversial. Therefore, this systematic review aimed to evaluate whether SVFs have positive effects, such as in accelerating tooth movement, alleviating pain, and preventing root resorption, in orthodontic patients.Search methodsSearches through five electronic databases (PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Central) were complemented by hand searches up to January, 2019.Selection criteriaRandomized controlled trials and controlled clinical trials reporting on the effects of SVFs in orthodontic patients in English were included.Data collection and analysisStudy selection, data extraction, and a risk of bias assessment were independently performed by two reviewers. Study characteristics and outcomes were reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A qualitative analysis of the effects of SVFs on orthodontic tooth movement, pain experience, and root resorption was conducted.ResultsThirteen studies, including nine clinical trials, were eligible for inclusion in the systematic review. There was no significant evidence to support the positive effects of SVFs in orthodontic patients, neither in accelerating tooth movement nor in alleviating pain experience. According to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria, the quality of the evidence was very low for all the outcomes in the qualitative analysis.LimitationsThe results of this systematic review are based on a limited number of studies and the methodological heterogeneity and non-comparability of original outcomes made it difficult to conduct a meta-analysis.ConclusionsThere is insufficient evidence to support the claim that SVFs have positive clinical advantages in the alignment of the anterior teeth. The potential positive effects of vibrational forces on space closure, pain experience, and root resorption in orthodontic patients are inconclusive with no sufficient information at present. High-quality clinical trials with larger sample sizes are needed to find more comprehensive evidence of the potential positive effects of vibrational forces.RegistrationThe protocol for this systematic review was registered on PROSPERO (CRD42018098788).FundingThis study has not received any contributions from private or public funding agencies.Conflict of InterestNone.
Neutral and polar lipid fatty acids in five families of demersal and pelagic fish from the deep Northwest Atlantic
Authors: Şen Özdemir Nurgül , Parrish Christopher C , Parzanini Camilla , Mercier Annie 
Published: March 2019

AbstractFatty acids in neutral and polar lipids were used to investigate trophic connections in species from five families of demersal (Rajella fyllae, Malacoraja senta, Alepocephalus bairdii, Borostomias antarcticus) and pelagic fish (Bathytroctes macrolepis, Lampanyctus spp., Chaulidos sloani, Serrivomer beanii) sampled in the deep Atlantic Ocean off Newfoundland, Canada. Lipid extracts were fractionated into neutral, acetone-mobile polar, and phospholipids to separate fatty acids in storage from those in membranes. Multivariate analysis of fatty acids showed that there were greater differences among the three lipid fractions than there were among the species when all fatty acid fractions were considered together. Neutral lipid fatty acids were characterized by monoenes, acetone-mobile polar lipids (AMPL) by C18 polyenes, and phospholipids by 16:0 and DHA. Multivariate analysis of fatty acids in phospholipids showed a strong grouping by taxonomic family (&gt;80% similarity), while the neutral lipid fatty acids showed a weaker grouping by family (72.5% similarity) but groupings that also related to habitat and vertical migration. The neutral lipid data supported the use of 20:1ω9 as a biomarker of calanoid copepods and of 16:1ω7 as a marker of diatoms to determine food web connections in deep-sea fish, but not some other common markers. In addition, correlations with δ15N showed that series of ω6 and ω7 fatty acids were trophically transferred though neutral lipids, especially the essential fatty acid, ARA. Neutral lipids were also reservoirs for essential ω3 fatty acids in demersal species, but the major reservoir for DHA was AMPL and phospholipid in pelagic species.
Universal first-order logic is superfluous in the second level of the polynomial-time hierarchy
Authors: Borges Nerio , Pin Edwin 
Published: March 2019

Abstract
In this paper we prove that $\forall \textrm{FO}$, the universal fragment of first-order logic, is superfluous in $\varSigma _2^p$ and $\varPi _2^p$. As an example, we show that this yields a syntactic proof of the $\varSigma _2^p$-completeness of value-cost satisfiability. The superfluity method is interesting since it gives a way to prove completeness of problems involving numerical data such as lengths, weights and costs and it also adds to the programme started by Immerman and Medina about the syntactic approach in the study of completeness.
Delayed Colonoscopy Following a Positive Fecal Test Result and Cancer Mortality
Authors: Flugelman Anath A , Stein Nili , Segol Ori , Lavi Idit , Keinan-Boker Lital 
Published: March 2019

Abstract

Background
A fecal test followed by diagnostic colonoscopy for a positive result is a widely endorsed screening strategy for colorectal cancer (CRC). However, the relationship between the time delay from the positive test to the follow-up colonoscopy and CRC mortality has not been established.

Methods
From a population-based screening program, we identified CRC patients newly diagnosed from 2005 through 2015 by a positive fecal occult test followed by a colonoscopy. The primary outcome measure was CRC-specific mortality according to four categories for the time elapsed between the positive result and the subsequent colonoscopy.

Results
The 1749 patients underwent colonoscopies within 0–3 months (n = 981, 56.1%), 4–6 months (n = 307, 17.5%), 7–12 months (n = 157, 9.0%), and later than 12 months (n = 304, 17.4%). CRC-specific deaths according to exposure groups were: 13.8% (135 of 981) for 0–3 months, 10.7% (33 of 307) for 4–6 months (crude hazards ratio [HR] = 0.74, 95% confidence interval [CI] = 0.51 to 1.14), 11.5% (18 of 157) for 7–12 months (crude HR = 0.83, 95% CI = 0.51 to 1.42), and 22.7% (69 of 304) for longer than 12 months (crude HR = 1.40, 95% CI = 1.04 to 1.90). The only variable that was associated with mortality risk was the number of positive slides (P = .003). High positivity was twice the value in the 0–3 as the longer-than-12 months group: 51.9% vs 25.0% and similar for the 4–6 and 7–12 months groups (38.1% and 36.5%), respectively. The adjusted HRs for CRC mortality were 0.81 (95% CI = 0.55 to 1.19); 0.83 (95% CI = 0.50 to 1.41), and 1.53 (95% CI = 1.13 to 2.12, P = .006) for the 4–12, 7–12, and longer-than-12-months groups, respectively, compared with the shortest delay group.

Conclusions
Among screen-diagnosed CRC patients, performance of colonoscopy more than 12 months after the initial positive fecal occult blood test was associated with more advanced disease and higher mortality due to CRC.
CjPLE, a PLENA-like gene, is a potential regulator of fruit development via activating the FRUITFUL homolog in Camellia
Authors: Lyu Tao , Fan Zhengqi , Yang Wen , Yan Chao , Hu Zhikang , Li Xinlei , Li Jiyuan , Yin Hengfu 
Published: March 2019

AbstractFruit patterning involves the cooperation of multiple processes, including metabolic change, cell differentiation, and cell expansion. The FRUITFUL (FUL) and SHATTERPROOF1/2 (SHPs) MADS-box genes are master regulators directing fruit patterning in several eudicots. However, the regulatory mechanisms of the FUL–SHP network in different fruit types remain unclear. Here, we characterized the functions of an ortholog (CjPLE) of SHPs from Camellia japonica. We showed that CjPLE was predominantly expressed in stamen and carpel tissues during the early stage of floral development and that transcripts were abundant in the pericarp tissues during fruit development. The ectopic expression of CjPLE in Arabidopsis caused enhanced development of the carpels, whereas no defects in floral identity were observed. To investigate the downstream targets of CjPLE, overexpression transformants were analysed through a callus transformation system in Camellia azalea. We examined the expression levels of potential downstream target genes and found that two previously identified APETALA1-like genes (CjAPL1/2) were significantly up-regulated. We showed that CjPLE directly bound to the CArG motifs in the promoter region of CjAPL1 (the FUL ortholog). Taken together, our results reveal a possible positive regulation of FUL by SHP in the control of fruit development in Camellia.
Orphan genes are involved in drought adaptations and ecoclimatic-oriented selections in domesticated cowpea
Authors: Li Guojing , Wu Xinyi , Hu Yaowen , Muñoz-Amatriaín Maria , Luo Jie , Zhou Wen , Wang Baogen , Wang Ying , Wu Xiaohua , Huang Lijuan , Lu Zhongfu , Xu Pei 
Published: March 2019

AbstractOrphan genes (OGs) are genes that are restricted to a single species or a particular taxonomic group. To date, little is known about the functions of OGs in domesticated crops. Here, we report our findings on the relationships between OGs and environmental adaptation in cowpea (Vigna unguiculata). We identified 578 expressed OGs, of which 73.2% were predicted to be non-coding. Transcriptomic analyses revealed a high rate of OGs that were drought inducible in roots when compared with conserved genes. Co-expression analysis further revealed the possible involvement of OGs in stress response pathways. Overexpression of UP12_8740, a drought-inducible OG, conferred enhanced tolerance to osmotic stresses and soil drought. By combining Capture-Seq and fluorescence-based Kompetitive allele-specific PCR (KASP), we efficiently genotyped single nucleotide polymorphisms (SNPs) on OGs across a 223 accession cowpea germplasm collection. Population genomic parameters, including polymorphism information content (PIC), expected heterozygosity (He), nucleotide diversity (π), and Tajima’s D statistics, that were calculated based on these SNPs, showed distinct signatures between the grain- and vegetable-type subpopulations of cowpea. This study reinforces the idea that OGs are a valuable resource for identifying new genes related to species-specific environmental adaptations and fosters new insights that artificial selection on OGs might have contributed to balancing the adaptive and agronomic traits in domesticated crops in various ecoclimatic conditions.
CHARACTERISATION OF TLDS-200 AND OSLDS AT LOW X-RAY ENERGIES AND DETERMINATION OF EYE LENS DOSE, THYROID DOSE AND MEAN GLANDULAR DOSE DURING STANDARD MAMMOGRAPHY AND TOMOSYNTHESIS
Authors: Pirchio R , Stefanic A , Rojas R R 
Published: March 2019

Abstract
The objective of this study was to characterise thermoluminescent (TLDs) and optically stimulated luminescent dosimeters (OSLDs) at low X-ray energies and estimate the eye lens (DL), thyroid (DT) and mean glandular (DG) doses received during Full-Field Digital Mammography (FFDM) and Digital Breast Tomosynthesis (DBT). The dosimeters were characterised in mammography energies. DL, DT and DG were estimated in FFDM and DBT mode taping dosimeters on the skin of the thyroid gland and on the left eye lens of an Alderson phantom. Dosimeters were also placed on the top of a NORMI PAS phantom simulating a compressed breast. The accuracy, precision and lower limit of detection (LLD) for TLDs and OSLDs were 5 and 8%, 6 and 3%, and 38 and 11 μSv, respectively. The linearity of the kerma response had an R2 &gt; 0.99 and energy dependence was lower than 40%. DT ranged from 0.40 to 2.87 μGy for FFDM and 1.27 to 5.99 μGy for DBT. DG was between 0.50 and 1.27 mGy for FFDM and 1.07 and 1.60 mGy for DBT. DL was below the LLD. Dosimeters showed good performance. DG values were lower than those found in the literature, whereas DT value agreed with references. Differences between DG and DT determined with OSLDs and TLDs were lower than 10% and 200%.
An updated meta-analysis of the association between Toxoplasma gondii infection and risk of epilepsy
Authors: Sadeghi Maryam , Riahi Seyed Mohammad , Mohammadi Mona , Saber Vafa , Aghamolaie Somayeh , Moghaddam Solmaz Alizadeh , Aghaei Shima , Javanian Mostafa , Gamble H Ray , Rostami Ali 
Published: March 2019

Abstract
Toxoplasma gondii is a neurotropic pathogen with worldwide distribution. To evaluate the association between Toxoplasma infection and the risk of epilepsy by meta-analysis, observational peer-reviewed studies were retrieved from PubMed, Embase, Web of Science, Scopus and Google Scholar (up to 10 October 2018) and by reference review. Pooled risk estimates were calculated using a random effects model. Heterogeneity was assessed using Cochrane’s Q-test and I2. In total, 16 eligible studies involving 19 data sets were included for the final analysis. A total 7897 participants (3771 epileptic patients, 4026 healthy controls) were included. The pooled odds ratio (OR) for Toxoplasma infection was increased to 1.72 (95% confidence interval [CI] 1.37 to 2.16) among patients with epilepsy. There was moderate heterogeneity among the studies (χ2=39.8, I2=62.3%, p=0.001). The ORs from subgroup analyses showed that both cryptogenic epilepsy (OR 2.65 [95% CI 1.91 to 3.68]) and active convulsive epilepsy (OR 1.37 [95% CI 1.09 to 1.72]) were significantly associated with Toxoplasma infection. Another subgroup analyses according to age showed a significant positive association in children (OR 1.33), adults (OR 1.57) and in all ages (OR 1.89). Our findings support the association between Toxoplasma infection and epilepsy. More prospective studies with larger sample sizes and more experimental studies are recommended to elucidate a causative relationship.
Transient Neurological Events After Surgery for Pediatric Moyamoya Disease: A Retrospective Study of Postoperative Sedation Practices
Authors: Matsuura Hideki , Yoshitani Kenji , Nakamori Yuki , Tsukinaga Akito , Takahashi Jun C. , Nakai Michikazu , Ohnishi Yoshihiko 
Published: March 2019

Background:
Moyamoya disease is a cerebrovascular disease characterized by bilateral stenosis of the intracranial internal carotid arteries and an abnormal collateral vascular network at the base of the brain. Transient neurological events (TNEs), which are episodes of neurological dysfunction lasting <24 hours, are associated with stroke in pediatric patients with Moyamoya disease. Perioperative agitation often occurs in pediatric patients. We hypothesized that anesthetic technique and postoperative sedation would modify the association between TNE and superficial temporal artery-middle cerebral artery (STA-MCA) bypass in pediatric patients with Moyamoya disease.

Methods:
We retrospectively reviewed the medical records of patients with Moyamoya disease aged 15 years and below who underwent STA-MCA bypass under general anesthesia at a single cerebrovascular center in Japan between January 1999 and March 2016. The primary outcome was TNE. Mixed-effects logistic regression was used to evaluate whether postoperative sedation and anesthetic agents were associated with TNE.

Results:
Among 277 hemispheres in 154 pediatric patients who underwent STA-MCA bypass, 107 patients (39%) experienced TNE within 1 week after surgery. Crying (adjusted odds ratio, 3.11; 95% confidence interval, 1.01-9.59; P=0.048) was an independent risk factor for TNE. Postoperative sedation was associated with a lower incidence of TNE (adjusted odds ratio, 0.514; 95% confidence interval, 0.264-0.997; P=0.049), but premedication and anesthetic agents were not associated with TNE.

Conclusion:
In pediatric patients with Moyamoya disease, crying was associated with increased TNE and postoperative sedation is associated with decreased TNE.
Neonatal and Maternal Morbidity Among Low-Risk Nulliparous Women at 39–41 Weeks of Gestation
Authors: Chen Han-Yang , Grobman William A. , Blackwell Sean C. , Chauhan Suneet P. 
Published: March 2019

OBJECTIVE:
To use a large national database to compare composite maternal or neonatal morbidity among low-risk, full-term women.

METHODS:
This cohort study, using the U.S. vital statistics datasets (2011–2015), evaluated low-risk nulliparous women with nonanomalous singleton gestations who labored at 39, 40, or 41 weeks of gestation (as reported in completed weeks of gestation; eg, 39 weeks include 39 0/7 to 39 6/7 weeks). The primary outcome, composite neonatal morbidity, included any of the following: Apgar score below 5 at 5 minutes, assisted ventilation longer than 6 hours, seizure, or mortality. The secondary outcome, composite maternal morbidity, included any of the following: intensive care unit admission, blood transfusion, uterine rupture, or unplanned hysterectomy. Multivariable Poisson regression was used to estimate the association between gestational age and morbidity (using adjusted relative risk [aRR] and 95% CI).

RESULTS:
Of 19.8 million live births during the study interval, 3.3 million met inclusion criteria: 43.5% were delivered at 39 weeks of gestation, 41.4% at 40 weeks, and 15.1% at 41 weeks. The overall rates of composite neonatal and maternal morbidity were 8.8 and 2.8 per 1,000 live births, respectively. Composite neonatal morbidity was higher for those delivered at 40 (aRR 1.22; 95% CI 1.19–1.25) and 41 (aRR 1.53; 95% CI 1.49–1.58) weeks of gestation when compared with 39 weeks. Composite maternal morbidity was also significantly higher with delivery at 40 (aRR 1.19; 95% CI 1.14–1.25) and 41 weeks of gestation (aRR 1.56; 95% CI 1.47–1.65).

CONCLUSION:
Among low-risk nulliparous women, the rate of composite neonatal and maternal morbidity increases, albeit modestly, from 39 through 41 weeks of gestation.
Safety Assessment of a Large-Scale Improvement Collaborative to Reduce Nulliparous Cesarean Delivery Rates
Authors: Main Elliott K. , Chang Shen-Chih , Cape Valerie , Sakowski Christa , Smith Holly , Vasher Julie 
Published: March 2019

OBJECTIVE:To evaluate maternal and neonatal safety measures in a large-scale quality improvement program associated with reductions in nulliparous, term, singleton, vertex cesarean delivery rates.METHODS:This is a cross-sectional study of the 2015–2017 California Maternal Quality Care Collaborative (CMQCC) statewide collaborative to support vaginal birth and reduce primary cesarean delivery. Hospitals with nulliparous, term, singleton, vertex cesarean delivery rates greater than 23.9% were solicited to join. Fifty-six hospitals with more than 119,000 annual births participated; 87.5% were community facilities. Safety measures were derived using data collected as part of routine care and submitted monthly to CMQCC: birth certificates, maternal and neonatal discharge diagnosis and procedure files, and selected clinical data elements submitted as supplemental data files. Maternal measures included chorioamnionitis, blood transfusions, third- or fourth-degree lacerations, and operative vaginal delivery. Neonatal measures included the severe unexpected newborn complications metric and 5-minute Apgar scores less than 5. Mixed-effect multivariable logistic regression model was used to calculate odds ratios (Ors) and 95% CIs.RESULTS:Among collaborative hospitals, the nulliparous, term, singleton, vertex cesarean delivery rate fell from 29.3% in 2015 to 25.0% in 2017 (2017 vs 2015 adjusted OR [aOR] 0.76, 95% CI 0.73–0.78). None of the six safety measures showed any difference comparing 2017 to 2015. As a sensitivity analysis, we examined the tercile of hospitals with the greatest decline (31.2%–20.6%, 2017 vs 2015 aOR 0.54, 95% CI 0.50–0.58) to evaluate whether they had greater risk of poor maternal and neonatal outcomes. Again, no measure was statistically worse, and the severe unexpected newborn complications composite actually declined (3.2%–2.2%, aOR 0.71, 95% CI 0.55–0.92).CONCLUSION:Mothers and neonates participating in a large-scale Supporting Vaginal Birth collaborative had no evidence of worsened birth outcomes, even in hospitals with large cesarean delivery rate reductions, supporting the safety of efforts to reduce primary cesarean delivery using American College of Obstetricians and Gynecologists and Society for Maternal-Fetal Medicine guidelines and enhanced labor support.