bluuebunny/crossref_metadata_2025_split huggingface dataset:
An immersive orientation programme to improve medical student integration and well‐being
Authors: Short Brooke , Lambeth Louise , David Michael , Ryall Mary‐Ann , Hood Carol , Pahalawatta Upuli , Dawson Amanda 
Published: July 2019

SummaryBackgroundMultiple common challenges exist for medical students transitioning to regional clinical placements, including a relative paucity of well‐being skills required for the promotion of work–life integration. Beginning Education at Central Coast Hospitals (BEACCHES) is an immersive orientation programme aimed at negotiating this transition and promoting student well‐being through improved social connectedness. The programme was evaluated with the objectives of understanding the most highly valued and effective components.MethodBEACCHES is offered to medical students commencing regional clinical placement at the Central Coast Medical School, Australia. The programme emphasises teamwork and self care, and promotes multidirectional interaction among peers, staff and the local community. A specific well‐being forum is an essential component of the programme. An evaluation of the inaugural programme was performed using semi‐structured surveys with a mixed‐method analysis of quantitative data (pre‐ and post‐programme knowledge and confidence scores) and qualitative data (emergent themes).ResultsKnowledge acquisition significantly improved across all domains. Importantly, this included items that could positively impact on well‐being, including: knowledge of psychological first aid (p = 0.01), student support services (p < 0.01), connectedness with fellow students and staff (p < 0.01), and self‐management of health and workload (p = 0.01). Qualitative analysis also revealed substantial support for the importance of interaction with peers and staff outside of the formal education setting.According to the Australian Medical Association, medical schools‘ responsibilities include incorporating curricula designed to improve stress managementConclusionOur survey results indicated that BEACCHES has the potential to foster student well‐being through targeted orientation and engagement to enhance connectedness. We highlight the value of embedding an interactive experiential programme for students beginning a new regional clinical placement.
Iron status and risk factors for iron depletion in a racially/ethnically diverse blood donor population
Authors: Spencer Bryan R. , Guo Yuelong , Cable Ritchard G. , Kiss Joseph E. , Busch Michael P. , Page Grier P. , Endres‐Dighe Stacy M. , Kleinman Steven , Glynn Simone A. , Mast Alan E. ,   For the National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III)
Published: July 2019

BACKGROUNDThe optimal approach for reducing iron depletion (ID) in blood donors may vary depending on biologic or behavioral differences across donors.STUDY DESIGN AND METHODSMore than 12,600 successful whole blood donors were enrolled from four US blood centers for ferritin testing. The study population was enriched for racial/ethnic minorities (1605 African American, 1616 Asian, 1023 Hispanic). Subjects completed questionnaires on ID risk factors. Logistic regression identified predictors of absent iron stores (AIS; ferritin <12 ng/mL) and low ferritin (LF; ferritin <26 ng/mL).RESULTSAcross all subjects, 19% had AIS and 42% had LF, with a sharp increase in risk observed with increasing donation intensity and among women a large decrease in risk in those more than 50 years old. When other factors were controlled for, African American and Asian donors showed 20% to 25% decreased risk for AIS compared to non‐Hispanic Caucasian donors, while Hispanic donors had 25% higher risk. Daily iron supplementation reduced risk for LF and AIS by 30% to 40%, respectively, while the benefit from less frequent use was lower (7%‐19% protection). Regular antacid use was associated with at least 20% increment to risk. Use of oral contraceptives or estrogen in females reduced risk by 16% to 22%, while males who reported supplemental testosterone use had a 50% to 125% greater risk for LF and AIS.CONCLUSIONSThis study confirms high prevalence of LF and AIS in US donors and the principal risk factors of age, sex, and donation frequency. Additional demographic and behavioral risk factors of secondary importance might allow for refinement of ID mitigation strategies.
Biotinylation of platelets for transfusion purposes a novel method to label platelets in a closed system
Authors: de Bruin Sanne , van de Weerdt Emma K. , Sijbrands Davina , Vlaar Richard , Gouwerok Eric , Biemond Bart J. , Vlaar Alexander P.J. , van Bruggen Robin , de Korte Dirk 
Published: July 2019

BACKGROUNDLabeling of platelets (PLTs) is required to measure the recovery and survival of transfused PLTs in vivo. Currently a radioactive method is used to label PLTs. However, application of those radiolabeling methods is limited by both safety issues and the inability to isolate transfused PLTs from the circulation. Biotin‐labeled PLTs are an attractive nonradioactive option. However, no validated protocol to biotinylate PLTs is currently available for human studies.STUDY DESIGN AND METHODSSix PLT concentrates (PCs) were subaliquoted and biotinylated on Days 1 and 7 of storage. To distinguish the effect of the processing steps from the effects of biotin incubation, two control groups were used: 1) “sham” samples were processed without the biotinylation reagent and 2) control samples were assessed without any processing other than the PC isolation. For the biotinylation procedure, 50 mL of PCs was washed twice and incubated with 5 mg/L biotin for 30 minutes in a closed system. As measures of PLT activation, phosphatidylserine exposure and CD62p expression were assessed.RESULTSAfter biotinylation, 98.4% ± 0.9% of PLTs were labeled. PLT counts, pH, and “swirling” were within the range accepted by the Dutch blood bank for standard PLT products. Biotinylated PLTs were more activated compared than controles but not more than sham samples, but were more activated than the controls.CONCLUSIONWe developed a standardized and reproducible protocol according to Good Practice Guidelines standards, for biotin labeling of PLTs for clinical purposes. This method can be applied as nonradioactive alternative assess survival and recovery of transfused PLTs in vivo.
Multifault Diagnosis of Combined Hydraulic and Mechanical Centrifugal Pump Faults Using Continuous Wavelet Transform and Support Vector Machines
Authors: Rapur Janani Shruti , Tiwari Rajiv 
Published: July 2019

Abstract
Centrifugal pumps (CPs) fail due to anomalies in fluid flow patterns and/or due to failure of mechanical subsystems in them. In this work, a technique built on the multiclass support vector machine (MSVM) is developed to identify multiple faults in the CP. In addition, the complex problem of fault combinations and their classification is dealt with in this work. The combination of features from motor line current sensors and accelerometers is used to train the algorithm. To take into account the transient as well as harmonic components of fault signatures, continuous wavelet transform (CWT) analysis is used. Thereafter, the most important information from the CWT coefficients is selected using the two proposed novel methods CWT-based on energy (BE)-MSVM and CWT-principal component analysis (PCA)-MSVM, which are BE as well as PCA, respectively. It is experimentally observed that faults in the CPs have a very strong association with its operating speed. Thus, in order to make the CP versatile in operation, it is important that the fault diagnosis methodology is also efficient at large speed range of CP operation. This work attempts to develop a fault classification methodology, which is independent of the CP operating speed.
High Speed Train Wireless Communication: Handover Performance Analysis for Different Radio Access Technologies
Authors: Banerjee Subharthi , Hempel Michael , Ghasemzadeh Pejman , Albakay Naji , Sharif Hamid 
Published: July 2019

High Speed Trains (HST) face some of the most stringent requirements for ensuring passenger safety and comfort while operating at very high velocities. HST wireless communication systems therefore similarly require special considerations for network design, technology selection and system implementation.
For infrastructure-based wireless communications, a handover occurs whenever a radio transitions from the coverage of the current base station to the next base station. The faster the train moves the shorter the time that it spends under coverage area before a handover is required. For HST this can be as short as 10–20 seconds. Furthermore, a HST moving at 220 mph experiences significant fast and small-scale wireless signal fading due to this velocity, but similarly may incur frequent connectivity losses due to the rapid transit across coverage areas. A route consisting of viaducts, bridges, tunnels or hilly regions drastically increases the need for rapid handovers since a large number of base stations are required to provide coverage and achieve acceptable Quality-of-Service (QoS) in such environments. Due to the relatively fixed amount of time needed to complete a handover, and the possibility of failed handovers, this reduces the usable time under coverage, and thus ensuring an optimal handover strategy selection is vital.
Most of the routes span rural and suburban areas, which reinforces the need for a comprehensive network planning strategy, as these areas tend to be underdeveloped for cellular coverage. Given the complexity in available radio spectrum resources, detailed studies are required to aid in this technology selection process. However, with the predicted increase in the demand of railroad network data traffic generated by onboard sensors, onboard control and operation devices, passenger Internet services, etc., it becomes apparent that more resources are needed than are provided by current technologies such as LTE. Thus, including 5G New Radio for Railways (5G-NR2) in the consideration does not only provide railways a more cost-effective licensing option for frequencies, but also an opportunity to select the best possible radio access method for a given HST corridor.
In this paper, we focus on the metrics related to handover and how they correlate with different radio access technologies for HST. Our results integrate the uncertainty of environmental factors to provide answers on technology selection driven by specific route, inter-site distances, and available bandwidth. Our wireless communication simulation results are driven by well recognized mathematical models that consider a variety of key parameters. The analysis of the handover performance will offer insights vital to future railroad network planning for multivariate radio access technologies, and to answer crucial questions about the potential for using frequency bands above 6 GHz in HST.
Effects of a Combined Upper- and Lower-Limb Plyometric Training Program on High-Intensity Actions in Female U14 Handball Players
Authors: Hammami Mehrez , Ramirez-Campillo Rodrigo , Gaamouri Nawel , Aloui Gaith , Shephard Roy J. , Chelly Mohamed Souhaiel 
Published: July 2019

Purpose: To analyze the effects of a 9-week plyometric training program on the sprint times (5, 10, 20, and 30 m), change-of-direction speed (modified T test and modified Illinois test), jumping (squat jump, countermovement jump, countermovement jump with arms, and horizontal 5-jump test), upper-body strength (right and left handgrip, back extensor strength, and medicine ball throw), and balance (Y and stork balance tests) of female handball players. Methods: Athletes were randomly divided into experimental (n = 21; age = 13.5 [0.3] y) and control (n = 20; age = 13.3 [0.3] y) groups. Training exercises and matches were performed together, but the experimental group replaced a part of their normal regimen by biweekly upper- and lower-limb plyometric training. Results: Both groups improved performance, but to a greater extent in the experimental group compared with controls for 20- and 30-m sprint times (Δ% = 9.6, P < .05, d = 0.557 and Δ% = 20.9, P < .001, d = 1.07, respectively), change of direction (T test: P < .01, Δ% = 14.5, d = 0.993 and Illinois test: P < .01, Δ% = 7.9, d = 0.769), vertical and horizontal jumping (P < .05), all measures of upper-limb strength (P < .001), and left-leg stork balance (P < .001, Δ% = 49.9, d = 1.07). Conclusions: A plyometric training program allows female junior handball players to improve important components of their physical performance.
Repeatability of automated leakage quantification and microaneurysm identification utilising an analysis platform for ultra-widefield fluorescein angiography
Authors: Jiang Alice , Srivastava Sunil , Figueiredo Natalia , Babiuch Amy , Hu Ming , Reese Jamie , Ehlers Justis P 
Published: July 2019

Background/aimsUltra-widefield fluorescein angiography (UWFA) provides unique opportunities for panretinal assessment of retinal diseases. The objective quantification of UWFA features is a labour-intensive manual process, limiting its utility. The present study assesses the consistency/repeatability of an automated assessment platform for the characterisation of retinal vascular features, quantification of microaneurysms (MA) and leakage foci in UWFA images.MethodsAn Institutional Review Board-approved retrospective image analysis study was performed on UWFA images. For each eye, two arteriovenous-phase images and two late-phase images were selected. Automated assessment was performed for retinal vascular features, MA identification and leakage segmentation. Panretinal and zonal assessment of metrics was performed.ResultsThere was a significant correlation between paired time points for retinal vessel area and vessel length on early images (Pearson r=0.92, p<0.0001; Pearson r=0.94, p<0.0001) and late images (Pearson r=0.92, p<0.0001; Pearson r=0.92, p<0.0001, respectively). Panretinal and zonal MA counts demonstrated high repeatability between images (all p<0.0001). Similarly, panretinal leakage area and zonal leakage areas were highly correlated (all p<0.001).ConclusionThis automated algorithm demonstrated very strong intrastudy correlation between paired time points in the same phases of the angiogram for quantifying retinal vascular characteristics, MA count and leakage parameters in UWFA images. These findings suggest significant flexibility in the platform for consistency in evaluating metrics over time and is encouraging for longitudinal assessment opportunities.
Expectations and experiences of hospital postnatal care in the UK: a systematic review of quantitative and qualitative studies
Authors: Malouf Reem , Henderson Jane , Alderdice Fiona 
Published: July 2019

ObjectivesTo report on women’s and families’ expectations and experiences of hospital postnatal care, and also to reflect on women’s satisfaction with hospital postnatal care and to relate their expectations to their actual care experiences.DesignSystematic review.SettingUK.ParticipantsPostnatal women.Primary and secondary outcomesWomen’s and families’ expectations, experiences and satisfaction with hospital postnatal care.MethodsEmbase, MEDLINE, PsycINFO, Applied Social Sciences Index and Abstracts, Cumulative Index to Nursing and Allied Health (CINAHL Plus), Science Citation Index, and Social Sciences Citation Index were searched to identify relevant studies published since 1970. We incorporated findings from qualitative, quantitative and mixed-methods studies. Eligible studies were independently screened and quality-assessed using a modified version of the National Institutes of Health Quality Assessment Tool for quantitative studies and the Critical Appraisal Skills Programme for qualitative studies. Data were extracted on participants’ characteristics, study period, setting, study objective and study specified outcomes, in addition to the summary of results.ResultsData were included from 53 studies, of which 28 were quantitative, 19 were qualitative and 6 were mixed-methods studies. The methodological quality of the included studies was mixed, and only three were completely free from bias. Women were generally satisfied with their hospital postnatal care but were critical of staff interaction, the ward environment and infant feeding support. Ethnic minority women were more critical of hospital postnatal care than white women. Although duration of postnatal stay has declined over time, women were generally happy with this aspect of their care. There was limited evidence regarding women’s expectations of postnatal care, families’ experience and social disadvantage.ConclusionWomen were generally positive about their experiences of hospital postnatal care, but improvements could still be made. Individualised, flexible models of postnatal care should be evaluated and implemented.PROSPERO registration numberCRD42017057913.
‘Connecting the dots’ for generating a momentum for Universal Health Coverage in Bangladesh: findings from a cross-sectional descriptive study
Authors: Ahmed Syed Masud , Rawal Lal B , Naher Nahitun , Hossain Tarek 
Published: July 2019

ObjectiveThis study was conducted to explore how and whether, the strategic grants made by the Rockefeller Foundation (RF) in different sectors of health systems in the inception phase were able to ‘connect the dots’ for ‘generating a momentum for Universal Health Coverage (UHC)’ in the country.DesignCross-sectional descriptive study, using document review and qualitative methods.SettingBangladesh, 17 UHC-related projects funded by the RF Transforming Health Systems (THS) initiative during 2010–2013.DataAvailable reports of the completed and on-going UHC projects, policy documents of the government relevant to UHC, key-informant interviews and feedback from grant recipients and relevant stakeholders in the policy and practice.Outcome measuresKey policy initiatives undertaken for implementing UHC activities by the government post grants disbursement.ResultsThe RF THS grants simultaneously targeted and connected the academia, the public and non-profit development sectors and news media for awareness-building and advocacy on UHC, develop relevant policies and capacity for implementation including evidence generation. This strategy helped relevant stakeholders to come together to discuss and debate the core concepts, scopes and modalities of UHC in an attempt to reach a consensus. Additionally, experiences gained from implementation of the pilot projects helped in identifying possible entry points for initiating UHC activities in a low resource setting like Bangladesh.ConclusionsDuring early years of UHC-related activities in Bangladesh, strategic investments of the RF THS initiative played a catalytic role in sensitising and mobilising different constituencies for concerted activities and undertaking necessary first steps. Learnings from this strategy may be of help to countries under similar conditions of ‘low resource, apparent commitment, but poor governance,’ on their journey towards UHC.
Textured shoe insoles to improve balance performance in adults with diabetic peripheral neuropathy: study protocol for a randomised controlled trial
Authors: Hatton Anna L , Gane Elise M , Maharaj Jayishni N , Burns Joshua , Paton Joanne , Kerr Graham , Rome Keith 
Published: July 2019

IntroductionPeripheral neuropathy is a major risk factor for falls in adults with diabetes. Innovative footwear devices which artificially manipulate the sensory environment at the feet, such as textured shoe insoles, are emerging as an attractive option to mitigate balance and walking problems in neuropathic populations. This study aims to explore whether wearing textured insoles for 4 weeks alters balance performance in adults with diabetic peripheral neuropathy.Methods and analysisA prospective, single-blinded randomised controlled trial with parallel groups will be conducted on 70 adults with diabetic peripheral neuropathy. Adults with a diagnosis of peripheral neuropathy (secondary to type 2 diabetes), aged ≥18 years, ambulant over 20 m (with/without an assistive device), will be recruited. Participants will be randomised to receive a textured insole (n=35) or smooth insole (n=35), to be worn for 4 weeks. During baseline and post intervention assessments, standing balance (foam/firm surface; eyes open/closed) and walking tasks will be completed barefoot, wearing standard shoes only, and two different insoles (smooth, textured). The primary outcome measure will be centre of pressure (CoP) velocity, with higher values indicating poorer balance. Secondary outcome measures include walking quality (gait velocity, base of support, stride length and double-limb support time), physical activity levels, foot sensation (light-touch pressure, vibration) and proprioception (ankle joint position sense), and other balance parameters (CoP path length, anteroposterior and mediolateral excursion). Patient-reported outcomes will be completed evaluating foot health, frequency of falls and fear of falling. Data will be analysed using a repeated measures mixed models approach (including covariates) to establish any differences between-groups, for all outcome measures, over the intervention period.Ethics and disseminationEthical approval has been obtained from the institutional Human Research Ethics Committee (#2017000098). Findings will be disseminated at national and international conferences, through peer-reviewed journals, workshops and social media.Trial registration numberACTRN12617000543381; Pre-results.
Protocol of the China ST-segment elevation myocardial infarction (STEMI) Care Project (CSCAP): a 10-year project to improve quality of care by building up a regional STEMI care network
Authors: Zhang Yan , Yu Bo , Han Yaling , Wang Jianan , Yang Lixia , Wan Zheng , Zhang Zheng , Chen Yuguo , Fu Xianghua , Gao Chuanyu , Li Bao , Chen Jiyan , Wu Ming , Ma Yitong , Zhao Xingsheng , Chen Yundai , Yan Hongbing , Xiang Dingcheng , Fang Weiyi , Mehta Sameer , Naber Christoph K , Ge Junbo , Huo Yong 
Published: July 2019

IntroductionSuccessful ST-segment elevation myocardial infarction (STEMI) management is time-sensitive and is based on prompt reperfusion mainly to reduce patient mortality. It has evolved from a single hospital care to an integrated regional network approach over the last decades. This prospective study, named the China STEMI Care Project (CSCAP), aims to show how implementation of different types of integrated regional STEMI care networks can improve the reperfusion treatment rate, shorten the total duration of myocardial ischaemia and lead to mortality reduction step by step.Methods and analysisThe CSCAP is a prospective, multicentre registry study of three phases. A total of 18 provinces, 4 municipalities and 2 autonomous regions in China were included. Patients who meet the third universal definition of myocardial infarction and the Chinese STEMI diagnosis and treatment guidelines are enrolled. Phase 1 (CSCAP-1) focuses on the in-hospital process optimisation of primary percutaneous coronary intervention (PPCI) hospitals, phase 2 (CSCAP-2) focuses on the PPCI hospital-based regional STEMI care network construction together with emergency medical services and adjacent non-PPCI hospitals, while phase 3 (CSCAP-3) focuses on the whole-city STEMI care network construction by promoting chest pain centre accreditation. Systematic data collection, key performance index assessment and subsequent improvement are implemented throughout the project to continuously improve the quality of STEMI care.Ethics and disseminationThe study has been reviewed and approved by the Ethics Committee of Peking University First Hospital. Ranking reports of quality of care will be generated available to all participant affiliations. Results will be disseminated via peer-reviewed scientific journals and presentations at congresses.Trial registration numberNCT03821012.