bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of User Personality Traits on Word of Mouth: Text-Mining Social Media Platforms
Authors: Adamopoulos Panagiotis , Ghose Anindya , Todri Vilma 
Published: May 2018

Word of mouth (WOM) plays an increasingly important role in shaping consumers’ behavior and preferences. In this paper, we examine whether latent personality traits of online users accentuate or attenuate the effectiveness of WOM in social media platforms. To answer this question, we leverage machine-learning methods in combination with econometric techniques utilizing a novel quasi-experiment. Our analysis yields two main results. First, there is a positive and statistically significant effect of the level of personality similarity between two social media users on the likelihood of a subsequent purchase from a recipient of a WOM message after exposure to the WOM message of the sender. In particular, exposure to WOM messages from similar users in terms of personality, rather than dissimilar users, increases the likelihood of a postpurchase by 47.58%. Second, there are statistically significant effects of specific pairwise combinations of personality characteristics of senders and recipients of WOM messages on the effectiveness of WOM. For instance, introverted users are responsive to WOM, in contrast to extroverted users. Besides this, agreeable, conscientious, and open social media users are more effective disseminators of WOM. In addition, WOM originating from users with low levels of emotional range affects similar users, whereas for high levels of emotional range, increased similarity usually has the opposite effect. The examined effects are also of significant economic importance, as, for instance, a WOM message from an extrovert user to an introvert peer increases the likelihood of a subsequent purchase by 71.28%. Our findings are robust to several alternative methods and specifications, such as controlling for latent user homophily and network structure roles based on deep-learning models. By extending the characteristics that have been theorized to affect the effectiveness of WOM from the observable to the latent space, tapping into users’ latent personality characteristics, and illustrating how companies can leverage the abundance of unstructured data in social media, our paper provides actionable insights regarding the future potential of social media advertising and advanced microtargeting based on big data and deep learning. The online appendix is available at https://doi.org/10.1287/isre.2017.0768 .
Does Platform Owner’s Entry Crowd Out Innovation? Evidence from Google Photos
Authors: Foerderer Jens , Kude Thomas , Mithas Sunil , Heinzl Armin 
Published: May 2018

We study how platform owners’ decision to enter complementary markets affects innovation in the ecosystem surrounding the platform. Despite heated debates on the behavior of platform owners toward complementors, relatively little is known about the mechanisms linking platform owners’ entry and complementary innovation. We exploit Google’s 2015 entry into the market for photography apps on its own Android platform as a quasi-experiment. We conclude based on our analyses of a time-series panel of 6,620 apps that Google’s entry was associated with a substantial increase in complementary innovation. We estimate that the entry caused a 9.6% increase in the likelihood of major updates for apps affected by Google’s entry, compared to similar but not affected apps. Further analyses suggest that Google’s entry triggered complementary innovation because of the increased consumer attention for photography apps, instead of competitive “racing” or “Red Queen” effects. This attention spillover effect was particularly pronounced for larger and more diversified complementors. The study advances our understanding of the effects of platform owner’s entry, explicates the complex mechanisms that shape complementary innovation, and adds empirical evidence to the debate on regulating platforms.The online appendix is available at https://doi.org/10.1287/isre.2018.0787 .
Robust Multiclass Queuing Theory for Wait Time Estimation in Resource Allocation Systems
Authors: Bandi Chaithanya , Trichakis Nikolaos , Vayanos Phebe 
Published: May 2018

In this paper, we study systems that allocate different types of scarce resources to heterogeneous allocatees based on predetermined priority rules—the U.S. deceased-donor kidney allocation system or the public housing program. We tackle the problem of estimating the wait time of an allocatee who possesses incomplete system information with regard, for example, to his relative priority, other allocatees’ preferences, and resource availability. We model such systems as multiclass, multiserver queuing systems that are potentially unstable or in transient regime. We propose a novel robust optimization solution methodology that builds on the assignment problem. For first-come, first-served systems, our approach yields a mixed-integer programming formulation. For the important case where there is a hierarchy in the resource types, we strengthen our formulation through a drastic variable reduction and also propose a highly scalable heuristic, involving only the solution of a convex optimization problem (usually a second-order cone problem). We back the heuristic with an approximation guarantee that becomes tighter for larger problem sizes. We illustrate the generalizability of our approach by studying systems that operate under different priority rules, such as class priority. Numerical studies demonstrate that our approach outperforms simulation. We showcase how our methodology can be applied to assist patients in the U.S. deceased-donor kidney waitlist. We calibrate our model using historical data to estimate patients’ wait times based on their kidney quality preferences, blood type, location, and rank in the waitlist. This paper was accepted by Yinyu Ye, optimization.
Alliance Formation and Firm Value
Authors: Cabral Luís , Pacheco-de-Almeida Gonçalo 
Published: May 2018

We consider the formation of alliances that potentially create complementarities, that is, when the value function is supermodular in firm resources. We show that, in a frictionless world where information is perfect and managers optimize, firm alliances disproportionately increase the value of high-resource-level firms, resulting in higher variance and higher skewness of the distribution of firm value; moreover, higher-value alliances are subject to regression to the mean at a faster rate. These effects are magnified if the degree of complementarities is endogenously determined by each firm’s investment. We also consider alliances where matching and/or information about firm resources are imperfect, and show that complementarities are a necessary but not sufficient condition for alliances to cause an increase in firm value; and that complementarities are neither a necessary nor a sufficient condition for alliances to be correlated with higher firm value. This paper was accepted by Olav Sorenson, organizations.
A Shortest-Path Algorithm for the Departure Time and Speed Optimization Problem
Authors: Franceschetti Anna , Honhon Dorothée , Laporte Gilbert , Van Woensel Tom 
Published: May 2018

We present a shortest-path algorithm for the departure time and speed optimization problem under traffic congestion. The objective of the problem is to determine an optimal schedule for a vehicle visiting a fixed sequence of customer locations to minimize a total cost function encompassing emissions cost and labor cost. We account for the presence of traffic congestion, which limits the vehicle speed during peak hours. We show how to cast this problem as a shortest-path problem by exploiting some structural results of the optimal solution. We illustrate the solution method and discuss some properties of the problem. The online appendix is available at https://doi.org/10.1287/trsc.2018.0820 .
The effect of femoral bone tunnel configuration on tendon-bone healing in an anterior cruciate ligament reconstruction
Authors: Sato Y. , Akagi R. , Akatsu Y. , Matsuura Y. , Takahashi S. , Yamaguchi S. , Enomoto T. , Nakagawa R. , Hoshi H. , Sasaki T. , Kimura S. , Ogawa Y. , Sadamasu A. , Ohtori S. , Sasho T. 
Published: May 2018

Objectives To compare the effect of femoral bone tunnel configuration on tendon-bone healing in an anterior cruciate ligament (ACL) reconstruction animal model. Methods Anterior cruciate ligament reconstruction using the plantaris tendon as graft material was performed on both knees of 24 rabbits (48 knees) to mimic ACL reconstruction by two different suspensory fixation devices for graft fixation. For the adjustable fixation device model (Socket group; group S), a 5 mm deep socket was created in the lateral femoral condyle (LFC) of the right knee. For the fixed-loop model (Tunnel group; group T), a femoral tunnel penetrating the LFC was created in the left knee. Animals were sacrificed at four and eight weeks after surgery for histological evaluation and biomechanical testing. Results Histologically, both groups showed a mixture of direct and indirect healing patterns at four weeks, whereas only indirect healing patterns were observed in both groups at eight weeks. No significant histological differences were seen between the two groups at four and eight weeks in the roof zone (four weeks, S: mean 4.8 sd 1.7, T: mean 4.5 sd 0.5, p = 0.14; eight weeks, S: mean 5.8 sd 0.8, T: mean 4.8 sd 1.8, p = 0.88, Mann-Whitney U test) or side zone (four weeks, S: mean 5.0 sd 1.2, T: mean 4.8 sd 0.4, p = 0.43; eight weeks, S: mean 5.3 sd 0.8,T: mean 5.5 sd 0.8, p = 0.61, Mann-Whitney U test) . Similarly, no significant difference was seen in the maximum failure load between group S and group T at four (15.6 sd 9.0N and 13.1 sd 5.6N) or eight weeks (12.6 sd 3.6N and 17.1 sd 6.4N, respectively). Conclusion Regardless of bone tunnel configuration, tendon-bone healing after ACL reconstruction primarily occurred through indirect healing. No significant histological or mechanical differences were observed between adjustable and fixed-loop femoral cortical suspension methods. Cite this article: Y. Sato, R. Akagi, Y. Akatsu, Y. Matsuura, S. Takahashi, S. Yamaguchi, T. Enomoto, R. Nakagawa, H. Hoshi, T. Sasaki, S. Kimura, Y. Ogawa, A. Sadamasu, S. Ohtori, T. Sasho. The effect of femoral bone tunnel configuration on tendon-bone healing in an anterior cruciate ligament reconstruction: An animal study. Bone Joint Res 2018;7:327–335. DOI: 10.1302/2046-3758.75.BJR-2017-0238.R2.
Detectable High-Sensitivity Cardiac Troponin within the Population Reference Interval Conveys High 5-Year Cardiovascular Risk: An Observational Study
Authors: Than Martin P , Aldous Sally J , Troughton Richard W , Pemberton Christopher J , Richards A Mark , Frampton Christopher M A , Florkowski Christopher M , George Peter M , Bailey Samantha , Young Joanna M , Cullen Louise , Greenslade Jaimi H , Parsonage William A , Everett Brendan M , Peacock W Frank , Jaffe Allan S , Pickering John W 
Published: May 2018

AbstractBACKGROUNDIncreased cardiac troponin I or T detected by high-sensitivity assays (hs-cTnI or hs-cTnT) confers an increased risk of adverse prognosis. We determined whether patients presenting with putatively normal, detectable cTn concentrations [&gt; limit of detection and &lt; upper reference limit (URL)] have increased risk of major adverse cardiovascular events (MACE) or all-cause mortality.METHODSA prospective 5-year follow-up of patients recruited in the emergency department with possible acute coronary syndrome (ACS) and cTn concentrations measured with hs-cTnI (Abbott) and hs-cTnT (Roche) assays. Cox regression models were generated with adjustment for covariates in those without MACE on presentation. Hazard ratios (HRs) for hs-cTn were calculated relative to the HRs at the median concentration.RESULTSOf 1113 patients, 836 were without presentation MACE. Of these, 138 incurred a MACE and 169 died during a median 5.8-year follow-up. HRs for MACE at the URLs were 2.3 (95% CI, 1.7–3.2) for hs-cTnI and 1.8 (95% CI, 1.3–2.4) for hs-cTnT. Corresponding HRs for mortality were 1.7 (95% CI, 1.2–2.2) for hs-cTnI and 2.3 (95 % CI, 1.7–3.1) for hs-cTnT. The HR for MACE increased with increasing hs-cTn concentration similarly for both assays, but the HR for mortality increased at approximately twice the rate for hs-cTnT than hs-cTnI. Patients with hs-cTnI ≥10 ng/L or hs-cTnT ≥16 ng/L had the same percentage of MACE at 5-year follow-up (33%) as patients with presentation MACE.CONCLUSIONSMany patients with ACS ruled out and putatively normal but detectable hs-cTnI concentrations are at similar long-term risk as those with MACE. hs-cTnT concentrations are more strongly associated with 5-year mortality than hs-cTnI.
Intellectual Traditions, Education, and Jihad: The (Non)Parallels between the Sokoto and Boko Haram Jihads
Authors: Lofkrantz Jennifer 
Published: May 2018

Abstract
In popular discourse many comparisons have been made between the nineteenth-century Sokoto and the twenty-first-century Boko Haram jihads. This article argues that the fundamental differences between the two jihads outweigh any surface similarities. Although both jihads took place in roughly the same geographic region, contemporary northern Nigeria and surrounding regions, and the leaders of both jihads called for the formation of a state based on a more “pure” or more “orthodox” form of Islam, they fundamentally differ on the bases of geographic center, ideology, leadership, and tactics. The article emphasizes intellectual and education networks in establishing the interpretations of Islam from which the Sokoto and Boko Haram jihadists derived their ideologies and justifications for their movements.
Ebola, Poverty, Economic Inequity and Social Injustice in Sierra Leone
Authors: M’bayo Tamba E. 
Published: May 2018

Abstract
The recent Ebola virus disease (EVD) epidemic in the West African countries of Guinea, Liberia, and Sierra Leone claimed the lives of slightly over eleven thousand victims by June 2015. Focusing on Sierra Leone, this article argues that the Ebola outbreak cannot be divorced from larger and chronic issues of poverty, economic inequality, and social injustice that have been the bane of the country’s stunted development in its postcolonial existence since 1961. Drawing on current historical literature on epidemiology in Africa, media reports, documents from the World Health Organization (WHO) and other international agencies such as Médicins Sans Frontières (MSF), and testimonies from Sierra Leoneans, the article aims to historicize and situate the Ebola epidemic in Sierra Leone within a wider context of poverty and related issues of economic inequity and social inequality.
Development of an ambulatory infusion protocol for Abatacept
Authors: Queffelec Karen , Anderson Michelle , Convery Holly , Reid Brenda 
Published: May 2018

The identification of the genetic causes of Common Variable Immune Deficiency (CVID) has led to recognition of the need for biological medications to treat the autoimmune manifestations that CVID patients with LRBA and CTLA4 deficiency experience. Immunologists have not traditionally used biological medications as treatment in CVID patients and may not be familiar with the use of them. We present the process and protocol as well as a nursing checklist used by the Division of Rheumatology for the use of Abatacept. Statement of novelty: The methodology used to develop the order set and nursing checklist may be applied to other biologic medications as they become available.
The Affective and Neural Correlates of Heroin versus Cocaine Use in Addiction Are Influenced by Environmental Setting But in Opposite Directions
Authors: De Pirro Silvana , Galati Gaspare , Pizzamiglio Luigi , Badiani Aldo 
Published: May 2018

Previous studies have shown that individuals with heroin and cocaine addiction prefer to use these drugs in distinct settings: mostly at home in the case of heroin and mostly outside the home in the case of cocaine. Here we investigated whether the context would modulate the affective and neural responses to these drugs in a similar way. First, we used a novel emotional task to assess the affective state produced by heroin or cocaine in different settings, based on the recollections of male and female drug users. Then we used fMRI to monitor neural activity during drug imagery (re-creating the setting of drug use) in male drug users. Consistent with our working hypothesis, the majority of participants reported a shift in the affective valence of heroin from mostly pleasant at home to mostly unpleasant outside the home (p< 0.0001). The opposite shift was observed for cocaine; that is, most participants who found cocaine pleasant outside the home found it unpleasant when taken at home (p< 0.0014). Furthermore, we found a double dissociation, as a function of drug and setting imagery, in BOLD signal changes in the left PFC and caudate, and bilaterally in the cerebellum (allpvalues <0.01), suggesting that the fronto-striatal-cerebellar network is implicated in the contextualization of drug-induced affect. In summary, we report that the same setting can influence in opposite directions the affective and neural response to psychostimulants versus opiates in humans, adding to growing evidence of distinct substrates for the rewarding effects of these two drug classes.SIGNIFICANCE STATEMENTThe rewarding effects of addictive drugs are often thought to depend on shared substrates. Yet, environmental influences can unmask striking differences between psychostimulants and opiates. Here we used emotional tasks and fMRI to explore the influence of setting on the response to heroin versus cocaine in individuals with addiction. Simply moving from one setting to another significantly decreased heroin pleasure but increased cocaine pleasure, and vice versa. Similar double dissociation was observed in the activity of the fronto-striatal-cerebellar network. These findings suggest that the effects of opiates and psychostimulants depend on dissociable psychological and neural substrates and that therapeutic approaches to addiction should take into account the peculiarities of different drug classes and the settings of drug use.
Structural and Functional Rescue of Chronic Metabolically Stressed Optic Nerves through Respiration
Authors: Harun-Or-Rashid Mohammad , Pappenhagen Nate , Palmer Peter G. , Smith Matthew A. , Gevorgyan Victoria , Wilson Gina N. , Crish Samuel D. , Inman Denise M. 
Published: May 2018

Axon degeneration can arise from metabolic stress, potentially a result of mitochondrial dysfunction or lack of appropriate substrate input. In this study, we investigated whether the metabolic vulnerability observed during optic neuropathy in the DBA/2J (D2) model of glaucoma is due to dysfunctional mitochondria or impaired substrate delivery to axons, the latter based on our observation of significantly decreased glucose and monocarboxylate transporters in D2 optic nerve (ON), human ON, and mice subjected to acute glaucoma injury. We placed both sexes of D2 mice destined to develop glaucoma and mice of a control strain, the DBA/2J-Gpnmb+, on a ketogenic diet to encourage mitochondrial function. Eight weeks of the diet generated mitochondria, improved energy availability by reversing monocarboxylate transporter decline, reduced glial hypertrophy, protected retinal ganglion cells and their axons from degeneration, and maintained physiological signaling to the brain. A robust antioxidant response also accompanied the response to the diet. These results suggest that energy compromise and subsequent axon degeneration in the D2 is due to low substrate availability secondary to transporter downregulation.SIGNIFICANCE STATEMENTWe show axons in glaucomatous optic nerve are energy depleted and exhibit chronic metabolic stress. Underlying the metabolic stress are low levels of glucose and monocarboxylate transporters that compromise axon metabolism by limiting substrate availability. Axonal metabolic decline was reversed by upregulating monocarboxylate transporters as a result of placing the animals on a ketogenic diet. Optic nerve mitochondria responded capably to the oxidative phosphorylation necessitated by the diet and showed increased number. These findings indicate that the source of metabolic challenge can occur upstream of mitochondrial dysfunction. Importantly, the intervention was successful despite the animals being on the cusp of significant glaucoma progression.
Survey of Human Chromosome 21 Gene Expression Effects on Early Development in Danio rerio
Authors: Edie Sarah , Zaghloul Norann A , Leitch Carmen C , Klinedinst Donna K , Lebron Janette , Thole Joey F , McCallion Andrew S , Katsanis Nicholas , Reeves Roger H 
Published: May 2018

Abstract
Trisomy for human chromosome 21 (Hsa21) results in Down syndrome (DS), one of the most genetically complex conditions compatible with human survival. Assessment of the physiological consequences of dosage-driven overexpression of individual Hsa21 genes during early embryogenesis and the resulting contributions to DS pathology in mammals are not tractable in a systematic way. A recent study looked at loss-of-function of a subset of Caenorhabditis elegans orthologs of Hsa21 genes and identified ten candidates with behavioral phenotypes, but the equivalent over-expression experiment has not been done. We turned to zebrafish as a developmental model and, using a number of surrogate phenotypes, we screened Hsa21 genes for effects on early embyrogenesis. We prepared a library of 164 cDNAs of conserved protein coding genes, injected mRNA into early embryos and evaluated up to 5 days post-fertilization (dpf). Twenty-four genes produced a gross morphological phenotype, 11 of which could be reproduced reliably. Seven of these gave a phenotype consistent with down regulation of the sonic hedgehog (Shh) pathway; two showed defects indicative of defective neural crest migration; one resulted consistently in pericardial edema; and one was embryonic lethal. Combinatorial injections of multiple Hsa21 genes revealed both additive and compensatory effects, supporting the notion that complex genetic relationships underlie end phenotypes of trisomy that produce DS. Together, our data suggest that this system is useful in the genetic dissection of dosage-sensitive gene effects on early development and can inform the contribution of both individual loci and their combinatorial effects to phenotypes relevant to the etiopathology of DS.