bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiseizure medication use during pregnancy and children’s neurodevelopmental outcomes
Authors: Madley-Dowd Paul , Ahlqvist Viktor H. , Forbes Harriet , Rast Jessica E. , Martin Florence Z. , Zhong Caichen , Barry Ciarrah-Jane S. , Berglind Daniel , Lundberg Michael , Lyall Kristen , Newschaffer Craig J. , Tomson Torbjörn , Davies Neil M. , Magnusson Cecilia , Rai Dheeraj , Lee Brian K. 
Published: November 2024

AbstractThe teratogenic potential of valproate in pregnancy is well established; however, evidence regarding the long-term safety of other antiseizure medications (ASMs) during pregnancy remains limited. Using routinely collected primary care data from the UK and nationwide Swedish registries to create a cohort of 3,182,773 children, of which 17,495 were exposed to ASMs in pregnancy, we show that those exposed to valproate were more likely to receive a diagnosis of autism, intellectual disability, and ADHD, when compared to children not exposed to ASMs. Additionally, children exposed to topiramate were 2.5 times more likely to be diagnosed with intellectual disability (95% CI: 1.23–4.98), and those exposed to carbamazepine were 1.25 times more likely to be diagnosed with autism (95% CI: 1.05–1.48) and 1.30 times more likely to be diagnosed with intellectual disability (95% CI: 1.01–1.69). There was little evidence that children exposed to lamotrigine in pregnancy were more likely to receive neurodevelopmental diagnoses. While further research is needed, these findings may support considering safer treatment alternatives well before conception when clinically appropriate.
Metallaphotocatalytic triple couplings for modular synthesis of elaborate N-trifluoroalkyl anilines
Authors: Zhou Ting , Zhang Zhong-Wei , Nie Jing , Kwong Fuk Yee , Ma Jun-An , Cheung Chi Wai 
Published: November 2024

AbstractThe integration of trifluoromethyl groups and three-dimensional quaternary carbon moieties into organic molecules has emerged as a prominent strategy in medicinal chemistry to augment drug efficacy. Although trifluoromethyl (hetero)aromatic amines and derivatives are prevalent frameworks in pharmaceuticals, the development of trifluoromethyl-embedded, intricately structured alkyl amine scaffolds for medicinal research remains a significant challenge. Herein, we present a metallaphotoredox multicomponent amination strategy employing 3,3,3-trifluoropropene, nitroarenes, tertiary alkylamines, and carboxylic acids. This synthetic pathway offers notable advantages, including the accessibility and cost-effectiveness of starting materials, high levels of chemo- and regioselectivity, and modularity. Furthermore, this approach enables the synthesis of a broad spectrum of aniline compounds featuring both trifluoromethyl group and distal quaternary carbon motifs along the aliphatic chains. The accelerated access to such elaborate N-trifluoroalkyl anilines likely involves three sequential radical-mediated coupling events, providing insightful implications for the retrosynthesis of potential compounds in organic synthesis and drug discovery.
Surface superconductivity in the topological Weyl semimetal t-PtBi2
Authors: Schimmel Sebastian , Fasano Yanina , Hoffmann Sven , Besproswanny Julia , Corredor Bohorquez Laura Teresa , Puig Joaquín , Elshalem Bat-Chen , Kalisky Beena , Shipunov Grigory , Baumann Danny , Aswartham Saicharan , Büchner Bernd , Hess Christian 
Published: November 2024

AbstractTopological superconductivity is a promising concept for generating fault-tolerant qubits. Early experimental studies looked at hybrid systems and doped intrinsic topological or superconducting materials at very low temperatures. However, higher critical temperatures are indispensable for technological exploitation. Recent angle-resolved photoemission spectroscopy results have revealed that superconductivity in the type-I Weyl semimetal—trigonal PtBi2 (t-PtBi2)—is located at the Fermi-arc surface states, which renders the material a potential candidate for intrinsic topological superconductivity. Here we show, using scanning tunnelling microscopy and spectroscopy, that t-PtBi2 presents surface superconductivity at elevated temperatures (5 K). The gap magnitude is elusive: it is spatially inhomogeneous and spans from 0 to 20 meV. In particular, the large gap value and the shape of the quasiparticle excitation spectrum resemble the phenomenology of high-Tc superconductors. To our knowledge, this is the largest superconducting gap so far measured in a topological material. Moreover, we show that the superconducting state at 5 K persists in magnetic fields up to 12 T.
SAGA1 and MITH1 produce matrix-traversing membranes in the CO2-fixing pyrenoid
Authors: Hennacy Jessica H. , Atkinson Nicky , Kayser-Browne Angelo , Ergun Sabrina L. , Franklin Eric , Wang Lianyong , Eicke Simona , Kazachkova Yana , Kafri Moshe , Fauser Friedrich , Vilarrasa-Blasi Josep , Jinkerson Robert E. , Zeeman Samuel C. , McCormick Alistair J. , Jonikas Martin C. 
Published: November 2024

AbstractApproximately one-third of global CO2 assimilation is performed by the pyrenoid, a liquid-like organelle found in most algae and some plants. Specialized pyrenoid-traversing membranes are hypothesized to drive CO2 assimilation in the pyrenoid by delivering concentrated CO2, but how these membranes are made to traverse the pyrenoid matrix remains unknown. Here we show that proteins SAGA1 and MITH1 cause membranes to traverse the pyrenoid matrix in the model alga Chlamydomonas reinhardtii. Mutants deficient in SAGA1 or MITH1 lack matrix-traversing membranes and exhibit growth defects under CO2-limiting conditions. Expression of SAGA1 and MITH1 together in a heterologous system, the model plant Arabidopsis thaliana, produces matrix-traversing membranes. Both proteins localize to matrix-traversing membranes. SAGA1 binds to the major matrix component, Rubisco, and is necessary to initiate matrix-traversing membranes. MITH1 binds to SAGA1 and is necessary for extension of membranes through the matrix. Our data suggest that SAGA1 and MITH1 cause membranes to traverse the matrix by creating an adhesive interaction between the membrane and matrix. Our study identifies and characterizes key factors in the biogenesis of pyrenoid matrix-traversing membranes, demonstrates the importance of these membranes to pyrenoid function and marks a key milestone toward pyrenoid engineering into crops for improving yields.
The mechanical and sensory signature of plant-based and animal meat
Authors: St. Pierre Skyler R. , Darwin Ethan C. , Adil Divya , Aviles Magaly C. , Date Archer , Dunne Reese A. , Lall Yanav , Parra Vallecillo María , Perez Medina Valerie A. , Linka Kevin , Levenston Marc E. , Kuhl Ellen 
Published: November 2024

AbstractEating less meat is associated with a healthier body and planet. Yet, we remain reluctant to switch to a plant-based diet, largely due to the sensory experience of plant-based meat. Food scientists characterize meat using a double compression test, which only probes one-dimensional behavior. Here we use tension, compression, and shear tests–combined with constitutive neural networks–to automatically discover the behavior of eight plant-based and animal meats across the entire three-dimensional spectrum. We find that plant-based sausage and hotdog, with stiffnesses of 95.9 ± 14.1 kPa and 38.7 ± 3.0 kPa, successfully mimic their animal counterparts, with 63.5 ± 45.7 kPa and 44.3 ± 13.2 kPa, while tofurky is twice as stiff, and tofu is twice as soft. Strikingly, a complementary food tasting survey produces in nearly identical stiffness rankings for all eight products (ρ = 0.833, p = 0.015). Probing the fully three-dimensional signature of meats is critical to understand subtle differences in texture that may result in a different perception of taste. Our data and code are freely available at https://github.com/LivingMatterLab/CANN
Population structure and selective signature analysis of local sheep breeds in Xinjiang, China based on high-density SNP chip
Authors: Li Yanhao , Li Xiaopeng , Han Zhipeng , Yang Ruizhi , Zhou Wen , Peng Yuwei , He Jianzhong , Liu Shudong 
Published: November 2024

AbstractThe frigid and droughty climate of Xinjiang in China has given rise to unique indigenous sheep breeds with robust adaptability and resistance. To investigate the genetic mechanism of adaptability of Xinjiang sheep to the local extreme environment, we conducted population genetic structure analyses for three native Xinjiang sheep breeds: Altay sheep (ALT), Bashbay Sheep (BSBC), and Duolang sheep (DLC), as well as two foreign sheep breeds: Suffolk and Dorset, using the Ovine Infinium HD SNP BeadChip(680 K). Our findings revealed distinct genetic and evolutionary histories between Xinjiang and foreign sheep breeds. Principal Component Analysis (PCA) and phylogenetic tree effectively differentiate these five sheep breeds based on their geographical origins, and the domestication level of Xinjiang sheep is comparatively lower than that of foreign sheep breeds. Furthermore, by utilizing three selective signature methods, namely Fixation Index (Fst), Cross Population Extended Haplotype Homozygosity Test (XP-EHH), and Nucleotide Diversity (π), we have successfully identified 22 potential candidate genes. Among these genes, there are TBXT, PDGFD, and VEGFA, which are closely related to tail type and lipid metabolism; VIL1, SLC11A1, and ZBTB46, which are associated with immune function; and candidate genes such as BNC1, HDAC1, and BMP5, which impact sheep reproductive traits. This study establishes a foundation for conserving and utilizing local sheep germplasm resources in Xinjiang and provides molecular insights into the genetic mechanisms governing sheep adaptation to extreme cold and arid environments.
Peak alpha frequency is linked to visual temporal attention in 6-month-olds
Authors: Arioli Martina , Mattersberger Matteo , Hoehl Stefanie , Brzozowska Alicja 
Published: November 2024

AbstractThe temporal resolution of adults’ visual attention has been linked to the frequency of alpha-band oscillations in electroencephalogram (EEG) signal, with higher Peak Alpha Frequency (PAF) being associated with better visual temporal processing skills. However, relatively less is known about neural mechanisms underlying individual differences in the temporal resolution of visual attention in infancy. This study investigated the role of PAF in visual temporal processing in early infancy. In a sample of 6-month-old infants (n = 62) we examined the relationship between PAF extracted from resting-state EEG, and saccadic latencies in a predictive cueing task where the appearance of a reward was predicted by higher or lower frequency of two flickering objects. Results showed that higher PAF was associated with shorter saccadic latencies in a condition with higher differences between the two flickering frequencies, speaking for the involvement of PAF in visual temporal attention in early development. Additionally, we found that infants were generally faster to orient to the reward in trials where both peripheral stimuli were flickering at relatively lower frequencies, roughly corresponding to the theta frequency band. Our findings support theoretical accounts highlighting the role of PAF in visual attention processing and extend this framework to early infancy.
Landscape patterns in stand-replacing disturbances across the world’s forests
Authors: Acil Nezha , Sadler Jonathan P. , Senf Cornelius , Suvanto Susanne , Pugh Thomas A. M. 
Published: November 2024

Abstract
The spatial imprint of forest disturbances, which can result from a variety of anthropogenic and natural causes, is important in shaping the form and function of the world’s forests. However, we lack a systematic assessment of how the forms of forest disturbances differ globally, which could help in sustainable forest policy and management initiatives to protect forest biomes. Here we produce a global-scale quantification of disturbance patch structures. Using indicators of magnitude, complexity and context, we found that the forms of stand-replacing disturbances can be classified into four broad patterns, whose spatial dominance varies across regions. Human activities were shown to introduce disturbance structures that are not naturally common, especially in the tropics. The consistency of these patterns across biomes outside intact forests suggests that a continuation of current dynamics may lead to a structural homogenization of the world’s forests, with potential consequences for forest ecology and functions. These results provide a greater understanding of the mechanisms governing forest dynamics and elucidating the causal agents of disturbances. This will be a key step towards building more reliable projections of future forest conditions, informing policymaking and ensuring the sustainability of forest management.
Mapping cellular stress and lipid dysregulation in Alzheimer-related progressive neurodegeneration using label-free Raman microscopy
Authors: Haessler Annika , Candlish Michael , Hefendehl Jasmin K. , Jung Nathalie , Windbergs Maike 
Published: November 2024

AbstractAβ plaques are a main feature of Alzheimer’s disease, and pathological alterations especially in their microenvironment have recently come into focus. However, a holistic imaging approach unveiling these changes and their biochemical nature is still lacking. In this context, we leverage confocal Raman microscopy as unbiased tool for non-destructive, label-free differentiation of progressive biomolecular changes in the Aβ plaque microenvironment in brain tissue of a murine model of cerebral amyloidosis. By developing a detailed approach, overcoming many challenges of chemical imaging, we identify spatially-resolved molecular signatures of disease-associated structures. Specifically, our study reveals nuclear condensation, indicating cellular degeneration, and increased levels of cytochrome c, showing mitochondrial dysfunction, in the vicinity of Aβ plaques. Further, we observe severe accumulation of especially unsaturated lipids. Thus, our study contributes to a comprehensive understanding of disease progression in the Aβ plaque microenvironment, underscoring the prospective of Raman imaging in neurodegenerative disorder research.
Effects of climate and forest development on habitat specialization and biodiversity in Central European mountain forests
Authors: Richter Tobias , Geres Lisa , König Sebastian , Braziunas Kristin H. , Senf Cornelius , Thom Dominik , Bässler Claus , Müller Jörg , Seidl Rupert , Seibold Sebastian 
Published: November 2024

AbstractMountain forests are biodiversity hotspots with competing hypotheses proposed to explain elevational trends in habitat specialization and species richness. The altitudinal-niche-breadth hypothesis suggests decreasing specialization with elevation, which could lead to decreasing species richness and weaker differences in species richness and beta diversity among habitat types with increasing elevation. Testing these predictions for bacteria, fungi, plants, arthropods, and vertebrates, we found decreasing habitat specialization (represented by forest developmental stages) with elevation in mountain forests of the Northern Alps – supporting the altitudinal-niche-breadth hypothesis. Species richness decreased with elevation only for arthropods, whereas changes in beta diversity varied among taxa. Along the forest developmental gradient, species richness mainly followed a U-shaped pattern which remained stable along elevation. This highlights the importance of early and late developmental stages for biodiversity and indicates that climate change may alter community composition not only through distributional shifts along elevation but also across forest developmental stages.
Ideal spin-orbit-free Dirac semimetal and diverse topological transitions in Y8CoIn3 family
Authors: Sato Manabu , Bouaziz Juba , Sumita Shuntaro , Kobayashi Shingo , Tateishi Ikuma , Blügel Stefan , Furusaki Akira , Hirayama Motoaki 
Published: November 2024

AbstractTopological semimetals, known for their intriguing properties arising from band degeneracies, have garnered significant attention. However, the discovery of a material realization and the detailed characterization of spinless Dirac semimetals have not yet been accomplished. Here, we propose from first-principles calculations that the RE8CoX3 group (RE = rare earth elements, X = Al, Ga, or In) contains ideal spinless Dirac semimetals whose Fermi surfaces are fourfold degenerate band-crossing points (without including spin degeneracy). Despite the lack of space inversion symmetry in these materials, Dirac points are formed on the rotation-symmetry axis due to accidental degeneracies of two bands corresponding to different 2-dimensional irreducible representations of the C6v group. We also investigate, through first-principles calculations and effective model analysis, various phase transitions caused by lattice distortion or elemental substitutions from the Dirac semimetal phase to distinct topological semimetallic phases such as nonmagnetic linked-nodal-line and Weyl semimetals (characterized by the second Stiefel–Whitney class) and ferromagnetic Weyl semimetals.
Health benefits of reduced deforestation in the Brazilian Amazon
Authors: Damm Yannic , Börner Jan , Gerber Nicolas , Soares-Filho Britaldo 
Published: November 2024

AbstractThe conversion of tropical forests in the Amazon region for agriculture and other land uses is associated with health risks linked, for example, to air and water pollution from forest fires and agrochemical use. Several conservation policies introduced in the 2000s aimed at reducing deforestation in the Brazilian Amazon. Here we exploit variations in the regional targeting of these policies to measure human health externalities of conservation policy enforcement using a double-difference approach at close distance to the Amazon biome border. We find that the change in deforestation pressure reduces forest fire incidence. As a consequence, fine particulate matter concentrations in the air—a main vector for adverse health effects of fire smoke—also decrease. This leads to a reduction in the hospitalization and death prevalence rate due to respiratory health problems and other health benefits for the local population.
A compact X-ray source via fast microparticle streams
Authors: Behling Rolf , Hulme Christopher , Poludniowski Gavin , Tolias Panagiotis , Danielsson Mats 
Published: November 2024

AbstractThe spatiotemporal resolution of diagnostic X-ray images is limited by the erosion and rupture of conventional stationary and rotating anodes of X-ray tubes from extreme density of input power and thermal cycling of the anode material. Conversely, detector technology has developed rapidly. Finer detector pixels demand improved output from brilliant keV-type X-ray sources with smaller X-ray focal spots than today and would be available to improve the efficacy of medical imaging. In addition, novel cancer therapy demands for greatly improved output from X-ray sources. However, since its advent in 1929, the technology of high-output compact X-ray tubes has relied upon focused electrons hitting a spinning rigid rotating anode; a technology that, despite of substantial investment in material technology, has become the primary bottleneck of further improvement. In the current study, an alternative target concept employing a stream of fast discrete metallic microparticles that intersect with the electron beam is explored by simulations that cover the most critical uncertainties. The concept is expected to have far-reaching impact in diagnostic imaging, radiation cancer therapy and non-destructive testing. We outline technical implementations that may become the basis of future X-ray source developments based on the suggested paradigm shift.
Stronger Together: A Qualitative Exploration of Social Connectedness in Parkinson's Disease in the Digital Era
Authors: Moya-Galé Gemma , Ahson Sarah , Gyawali Sneha , Lee Christina , O'Riordan Claire , Rossi Lily 
Published: November 2024

Purpose:
Social isolation is a common consequence of Parkinson's disease (PD), and social prescribing has become a crucial aspect for fostering well-being in this population. In fact, group work has been shown to improve levels of social connectedness in older adults across different domains. Increased technology use in older adults may also contribute to increased social connections, especially since the COVID-19 pandemic. Still, the impact of digital use on social connectedness remains to be further explored in individuals with PD. Therefore, the purpose of this study was to examine the perceptions of social connectedness in relation with group-based activities and use of digital technologies in this population.

Method:
Ten individuals with PD participated in focus groups. Transcripts of the video-recorded groups were analyzed qualitatively using thematic analysis.

Results:
The three constructed themes not only revealed changes and challenges in social connectedness but also underscored the power of family and new relationships established through PD. Results also highlighted the overall positive impact of current digital technologies, although the view on telehealth per se was multifaceted.

Conclusions:
Referrals for group rehabilitation programs can enhance social connectedness in individuals with PD through fostering new social connections and community building. Hence, group rehabilitation programs should be viewed as a form of social prescribing. The use of digital technologies should be further explored as a means to maximize social engagements in this population.
Progression of Motor Speech Function in Speakers With Primary Progressive Apraxia of Speech
Authors: Meade Gabriela , Pham Nha Trang Thu , Clark Heather M. , Duffy Joseph R. , Whitwell Jennifer L. , Josephs Keith A. , Utianski Rene L. 
Published: November 2024

Purpose:
Speakers with primary progressive apraxia of speech (PPAOS) have an insidious onset of motor speech planning/programming difficulties. As the disease progresses, the apraxia of speech (AOS) becomes more severe and a co-occurring dysarthria often emerges. Here, longitudinal data from speakers with phonetic- and prosodic-predominant PPAOS are used to characterize the progression of their motor speech impairment, including the development of dysarthria and mutism.

Method:
Data are presented from 52 speakers who had PPAOS at enrollment (i.e., progressive AOS in the absence of aphasia, cognitive, or other neurologic symptoms). Twenty-one had predominantly phonetic features, whereas 31 had primarily prosodic features. All participants underwent a comprehensive motor speech evaluation at their enrollment visit and each annual return visit, with a median of three visits per participant.

Results:
Almost 25% of the speakers with PPAOS presented with dysarthria at their enrollment visit (median disease duration of 3.65 years), whereas more than 70% of them had developed dysarthria by their last visit (median disease duration of 6.85 years). Neither the likelihood to develop dysarthria nor the disease duration at which it was detected differed significantly between the phonetic and prosodic groups. However, muteness emerged sooner for speakers with phonetic-predominant PPAOS; the median disease duration at which they became mute was 1.5 years shorter than for their prosodic counterparts.

Conclusions:
Clinically, these results facilitate more accurate prognostication of motor speech symptoms in speakers with PPAOS, allowing for timely introduction of alternative means of communication. The results also support the differentiation between progressive AOS and dysarthria as distinct motor speech disorders that often co-occur in these individuals.