bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mid‐term safety and efficacy of the ALTIS® single‐incision sling for female stress urinary incontinence: less mesh, same results
Authors: Morán Eduardo , Pérez‐Ardavín Javier , Sánchez Jose V. , Bonillo Miguel A. , Martínez‐Cuenca Esther , Arlandis Salvador , Broseta Enric , Boronat Francisco 
Published: September 2018

ObjectiveTo analyse the mid‐term safety and efficacy of the ALTIS® single‐incision sling (Coloplast Corp., Minneapolis, MN, USA) for female stress urinary incontinence (SUI).Patients and MethodsWe conducted a prospective, single‐arm, unsponsored, observational single‐centre trial in a cohort of patients undergoing SUI surgery with the ALTIS procedure. All patients were diagnosed according to clinical reports, physical exploration and urodynamics. Body mass index (BMI) was categorised according to World Health Organization classification. Valsalva leak‐point pressure (VLPP) was categorised in three groups: <60, 60–90 and >90 cmH2O. Patients were evaluated postoperatively at 1, 6, 12 and 24 months with physical examination, International Consultation on Incontinence Questionnaire Short Form (ICIQ‐SF), and satisfaction visual scale (SVS; score 0–10). Adverse events were assessed at each visit. Multivariate analysis for risk factors of surgery failure was performed.ResultsWe recruited 110 women, with a mean (SD) follow‐up of 22.34 (10.34) months. Regarding efficacy, 91 patients (82.7%) were objectively cured and 97 (88.2%) were subjectively cured. Regarding VLPP and BMI, no differences were seen between groups (P > 0.05). There was a ~20% decrease in urge UI (P = 0.04). No variable showed to be an independent risk factor for ALTIS failure (P > 0.05). Overall, nearly 96% of the women reported 9 or 10 points on the SVS. A total of 24 patients (21.8%) had some kind of complication. No mesh erosion was reported in any patient.ConclusionsThe ALTIS sling demonstrated to be an effective and safe procedure for SUI in the mid‐term setting. Objective and subjective cure rates are at least comparable to ‘gold standard’ procedures with a minimal rate of self‐limiting non‐surgical complications.
Comparing Traditional‐Residential, Personalised Residential and Personalised Non‐Residential respite services: Quality of life findings from an Irish population with mild–moderate intellectual disabilities
Authors: Nicholson Emma , Guerin Suzanne , Keogh Fiona , Dodd Philip 
Published: September 2018

Accessible Summary

This study looked at differences between three types of respite care for people with intellectual disabilities.

The three types of respite care were: 1) an overnight stay in a residential facility, 2) an overnight stay, where the person could choose where they stayed and what they did during their time in respite care, and 3) a non‐overnight service where people were supported to choose what they wanted to and who they wanted to spend time with in respite care.

Where people using respite care had a choice as to how they spent their time they were reported to have higher levels of emotional well‐being, personal development, rights and interpersonal relationships.

These results are important because they show that giving people choice in how they spend time in respite care might have better outcomes than Traditional‐Residential forms of respite care.

AbstractBackgroundRespite care is an essential support for people with intellectual disabilities and their families; however, there is limited evidence examining different models of respite care. The present research examined quality of life among adults with intellectual disabilities using three different models of respite services in Ireland.MethodA quasi‐experimental research method was adopted, which sought to determine differences in quality of life across the three respite care groups using two measures, 1) a self‐reported quality of life scale and 2) a quality of life questionnaire filled out by a keyworker. Participants were people with mild/moderate intellectual disabilities (n = 82) and their keyworkers (n = 81).ResultsThree distinct models of respite services were assessed: (a) Traditional‐ Residential respite; (b) Personalised Residential respite, and (c) Personalised Non‐Residential respite. No differences emerged between the groups on self‐reported quality of life; however, the groups differed on a proxy measure of quality of life with respect to Rights, emotional well‐being, personal development and interpersonal relationships.ConclusionThe current data offer an initial exploration of self‐ and proxy‐reported quality of life among persons with intellectual disabilities in receipt of novel models of respite care in Ireland.
Diethyldithiocarbamate, an anti‐abuse drug, alleviates steatohepatitis and fibrosis in rodents through modulating lipid metabolism and oxidative stress
Authors: Liu Tianhui , Wang Ping , Cong Min , Zhao Xinyan , Zhang Dong , Xu Hufeng , Liu Lin , Jia Jidong , You Hong 
Published: September 2018

Background and PurposeDiethyldithiocarbamate (DDC) is a major metabolite of disulfiram that is a potential drug for alcoholism treatment. In the present study, we attempted to explore the possible effect of DDC on non‐alcoholic fatty liver disease (NAFLD) and related fibrosis in vivo.Experimental ApproachC57BL/6 mice and Sprague Dawley (SD) rats received a methionine/choline‐deficient (MCD) diet to establish the model of NAFLD with or without DDC treatment. The livers and serum were assessed for histological changes and parameters related to lipid metabolism, liver injury, inflammation and fibrosis. Apoptosis and macrophage related markers were assessed by immunohistochemistry (IHC).Key ResultsDDC significantly reduced hepatic steatosis in rats with NAFLD, induced by the MCD diet. DDC reduced the oxidative stress and endoplasmic reticulum stress‐related parameters in mice with non‐alcoholic steatohepatitis, induced by the MCD diet. IHC for Bax and cleaved caspase‐3 showed that DDC inhibited the apoptosis of hepatocytes in the liver. DDC significantly reduced ballooning and Mallory−Denk bodies (MDB) in hepatocytes, accompanied by suppression of serum alanine aminotransferase, aspartate aminotransferase and MDB formation‐related genes. DDC significantly alleviated hepatic inflammation, accompanied by suppression of inflammation‐related genes. DDC suppressed the infiltration of macrophages, particularly inducible NOS‐positive pro‐inflammatory macrophages. In addition, DDC significantly alleviated liver fibrosis. Microarray analyses showed that DDC strongly affected lipid metabolism and oxidative stress‐related processes and pathways.Conclusion and ImplicationsDDC improves hepatic steatosis, ballooning, inflammation and fibrosis in rodent models of NAFLD through modulating lipid metabolism and oxidative stress.
ABT‐199 (Venetoclax), a BH3‐mimetic Bcl‐2 inhibitor, does not cause Ca2+‐signalling dysregulation or toxicity in pancreatic acinar cells
Authors: Jakubowska Monika A , Kerkhofs Martijn , Martines Claudio , Efremov Dimitar G , Gerasimenko Julia V , Gerasimenko Oleg V , Petersen Ole H , Bultynck Geert , Vervliet Tim , Ferdek Pawel E 
Published: September 2018

Background and PurposeMany cancer cells depend on anti‐apoptotic B‐cell lymphoma 2 (Bcl‐2) proteins for their survival. Bcl‐2 antagonism through Bcl‐2 homology 3 (BH3) mimetics has emerged as a novel anti‐cancer therapy. ABT‐199 (Venetoclax), a recently developed BH3 mimetic that selectively inhibits Bcl‐2, was introduced into the clinic for treatment of relapsed chronic lymphocytic leukaemia. Early generations of Bcl‐2 inhibitors evoked sustained Ca2+ responses in pancreatic acinar cells (PACs) inducing cell death. Therefore, BH3 mimetics could potentially be toxic for the pancreas when used to treat cancer. Although ABT‐199 was shown to kill Bcl‐2‐dependent cancer cells without affecting intracellular Ca2+ signalling, its effects on PACs have not yet been determined. Hence, it is essential and timely to assess whether this recently approved anti‐leukaemic drug might potentially have pancreatotoxic effects.Experimental ApproachSingle‐cell Ca2+ measurements and cell death analysis were performed on isolated mouse PACs.Key ResultsInhibition of Bcl‐2 via ABT‐199 did not elicit intracellular Ca2+ signalling on its own or potentiate Ca2+ signalling induced by physiological/pathophysiological stimuli in PACs. Although ABT‐199 did not affect cell death in PACs, under conditions that killed ABT‐199‐sensitive cancer cells, cytosolic Ca2+ extrusion was slightly enhanced in the presence of ABT‐199. In contrast, inhibition of Bcl‐xL potentiated pathophysiological Ca2+ responses in PACs, without exacerbating cell death.Conclusion and ImplicationsOur results demonstrate that apart from having a modest effect on cytosolic Ca2+ extrusion, ABT‐199 does not substantially alter intracellular Ca2+ homeostasis in normal PACs and should be safe for the pancreas during cancer treatment.Linked ArticlesThis article is part of a themed section on Mitochondrial Pharmacology: Featured Mechanisms and Approaches for Therapy Translation. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.22/issuetoc
The immunome of soy bean allergy: Comprehensive identification and characterization of epitopes
Authors: Kern Karolin , Havenith Heide , Delaroque Nicolas , Rautenberger Paul , Lehmann Jörg , Fischer Markus , Spiegel Holger , Schillberg Stefan , Ehrentreich‐Foerster Eva , Aurich Stefanie , Treudler Regina , Szardenings Michael 
Published: September 2018

SummaryBackgroundThe precise mapping of multiple antibody epitopes recognized by patients’ sera allows a more detailed and differentiated understanding of immunological diseases. It may lead to the development of novel therapies and diagnostic tools.ObjectiveMapping soy bean specific epitopes relevant for soy bean allergy patients and persons sensitized to soy bean, and analysis of their IgE/IgG binding spectrum.MethodsIdentification of epitopes using sera, applying an optimized peptide phage display library followed by next‐generation sequencing, specially designed in silico data analysis and subsequent peptide microarray analysis.ResultsWe were able to identify more than 400 potential epitope motifs in soy bean proteins. More than 60% of them have not yet been described as potential epitopes. Eighty‐three peptides, representing the 42 most frequently found epitope candidates, were validated by microarray analysis using 50 sera from people who have been tested positive in skin prick test (SPT). Of these peptides, 56 were bound by antibodies, 55 by serum IgE, 43 by serum IgG and 30 by both. Person‐specific epitope patterns were found for each individual and protein.ConclusionsFor individuals with clinical symptoms, epitope resolved analyses reveal a high prevalence of IgE binding to a few soy bean specific epitopes. Evaluation of individual immune profiles of patients with soy bean sensitization allows the identification of peptides that do facilitate studying individual IgE/IgG epitope binding patterns. This enables discrimination of sensitization from disease, such assay test has the potential to replace SPT assays
Health‐related quality of life improves 1 year after parathyroidectomy in primary hyperparathyroidism: A prospective cohort study
Authors: Ejlsmark‐Svensson Henriette , Sikjaer Tanja , Webb Susan M. , Rejnmark Lars , Rolighed Lars 
Published: September 2018

AbstractObjectiveImpaired quality of life (QoL) in primary hyperparathyroidism (PHPT) is commonly present. Patients may complain about nonspecific neurocognitive symptoms which can be difficult to quantify. Two different disease‐specific questionnaires have been developed, that is, the parathyroid assessment of symptoms score (PAS) and the primary hyperparathyroidism quality of life (PHPQoL). Using these two questionnaires, we assessed relationship between QoL and biochemical indices in PHPT and effects of parathyroidectomy (PTX).DesignA prospective cohort study.MethodsPatients with PHPT diagnosed from 2015 to 2017 were asked to answer the questionnaires before and 12 months after PTX. Biochemistry was obtained on both occasions.ResultsA total of 104 PHPT patients answered PAS and PHPQoL questionnaires at baseline, with a median age of 64 years (73% females). PHPQoL score correlated inversely with ionized calcium and PTH at baseline (P ˂ 0.04). Total PAS and PHPQoL score did not differ between those with and without osteoporosis, renal calcifications and impaired renal function. Based on levels of ionized calcium, PHPQoL differed significantly between patients with mild‐ and moderate‐severe hypercalcemia (P = 0.01). Fifty‐three patients answered PAS and PHPQoL 12 months after PTX showing an improved QoL at follow‐up (Pall ˂ 0.02). Stratifying patients into groups based on levels of ionized calcium showed a significantly improved PHPQoL score in patients with mild (˂1.45 mmol/L) as well as moderate‐severe hypercalcemia (≥1.45 mmol/L) at follow‐up (Pall ˂ 0.03).ConclusionQuality of life improved 12 months after PTX in PHPT patients. Impaired QoL seems to be associated with the degree of hypercalcemia rather than organ manifestations attributable to PHPT.
Clinical and radiographic outcomes of a surgical reconstructive approach in the treatment of peri‐implantitis lesions: A 5‐year prospective case series
Authors: La Monaca Gerardo , Pranno Nicola , Annibali Susanna , Cristalli Maria Paola , Polimeni Antonella 
Published: September 2018

AbstractObjectivesThe aim of this study was to evaluate the 5‐year clinical and radiographic outcomes following reconstructive therapy of peri‐implantitis lesions using mineralized dehydrated bone allograft and resorbable membrane in the nonsubmerged mode of wound healing.Materials and methodsThirty‐four patients with at least one implant diagnosed with peri‐implantitis were treated by mechanical debridement; chemical decontamination using hydrogen peroxide (3%), chlorhexidine (0.2%), and a tetracycline hydrochloride solution; and bone defect filling with mineralized dehydrated bone allograft and resorbable membrane. Clinical and radiographic assessments were obtained during 5‐year follow‐up. The primary outcome was the absence of additional marginal peri‐implant bone loss ≥1.0 mm after surgery, and the composite outcome included the additional marginal peri‐implant bone loss, absence of probing depth (PD) ≥5 mm, and absence of bleeding on probing (BoP)/suppuration.ResultsAccording to the primary and composite outcomes, the success rate of 34 implants included in the study was 100% and 91% (N = 31), at 1 year after surgery, and decreased progressively to 77% (N = 26) and to 59% (N = 20) at 5‐year follow‐up, respectively. Five years following treatment, only the BoP reduction was statistically significant compared to baseline (p < 0.001), and no difference was found in PD (p = 0.318) and in marginal peri‐implant bone level (p = 0.064).ConclusionsAt 1‐year follow‐up, the surgical reconstructive therapy showed clinical improvement and radiographic defect filling. However, the results appeared to be unpredictable over time, due to a progressive decrease in the bone filling of the peri‐implant defects and an increase in the mean PD.
Guided bone regeneration using beta‐tricalcium phosphate with and without fibronectin—An experimental study in rats
Authors: Escoda‐Francolí Jaume , Sánchez‐Garcés María Ángeles , Gimeno‐Sandig Álvaro , Muñoz‐Guzón Fernando , Barbany‐Cairó Joan R. , Badiella‐Busquets Llorenç , Gay‐Escoda Cosme 
Published: September 2018

AbstractObjectiveThis histomorphometric study compared bone regeneration potential of beta‐tricalcium phosphate with fibronectin (β‐TCP‐Fn) in critical‐sized calvarial defects (CSDs) in rats to assess whether fibronectin (Fn) improved new bone formation.Material and methodsCritical‐sized calvarial defects were created in 30 adult male Sprague Dawley rats, which were divided into four groups according to the time of euthanasia (6 or 8 weeks of healing) and type of filling (β‐TCP‐Fn/6 weeks, β‐TCP/6 weeks, β‐TCP‐Fn/8 weeks and β‐TCP/8 weeks). The primary variables related to new bone formation were augmented area (AA) and gained tissue (GT; sum of mineralized bone matrix [MBM] and bone substitute [BS]). Secondary variables were the diameter of the defect, MBM, non‐mineralized tissue (NMT) and BS.ResultsA total of 29 rats and 58 histological samples were evaluated, 28 (48.3%) samples obtained at 6 weeks and 30 (51.7%) at 8 weeks, homogeneously distributed between right and left sides. Thirteen (22.4%) were treated with β‐TCP‐Fn, 16 (27.6%) with β‐TCP and 29 (50%) were controls. At 8 weeks, histomorphometric analysis showed significant differences in AA using β‐TCP and β‐TCP‐Fn versus controls (p = 0.001 and p = 0.005, respectively). Bone turnover expressed as % within the target area was slightly higher but not statistically significant in the β‐TCP‐Fn than in β‐TCP (MBM) at 6 weeks versus 8 weeks (p = 0.067 and p = 0.335, respectively). Finally, the total GT area in mm2 was higher using β‐TCP‐Fn as compared to β‐TCP (p = 0.044).Conclusionsβ‐TCP‐Fn was slightly but non‐significantly more effective than β‐TCP without Fn for improving the volume of regenerated bone in CSDs of rats, possibly allowing a more efficient bone remodelling process. This effect however should continue being investigated.
A retrospective cohort study of peri‐implant condition in Chinese patients with different periodontal condition and maintenance frequency
Authors: Xie Yesi , Meng Huanxin , Han Jie , Xu Li , Zhang Li , Li Wenjing 
Published: September 2018

AbstractObjectivesTo compare the periodontal and peri‐implant conditions of Chinese patients with a history of moderate or severe periodontitis and periodontally healthy patients (PHP); to evaluate the influence of maintenance therapy frequency on the outcome of implant therapy.MethodsA total of 140 participants with 227 sand‐blasted acidetched (SLA) implants were divided into three groups: PHP, moderate periodontally compromised patients (PCP) and severe PCP. The three groups were further categorized into two groups based on the frequency of maintenance (MF): MF ≥ 1 per year and MF < 1 per year. The following clinical parameters of implants were assessed: implant survival/loss, peri‐implant probing depth (PDi), peri‐implant bleeding index (BIi), peri‐implant bleeding on probing (BOPi), implant bone loss (BLi). Comparisons of the peri‐implant conditions were performed between the patients with different periodontal conditions.ResultsImplant survival rate was 100% for all three groups. The severe PCP group showed significantly higher deepest PDi, mean PDi, mean BIi, and PLIi compared with PHP (p < 0.05). The severe PCP group had more implants affected with PDi ≥ 5 mm and BOPi+ compared with the PHP group (Adjusted OR = 10.89, 95% CI: 2.34, 50.74). In the patients with severe PCP, the MF < 1 per year group had a greater prevalence of PDi ≥ 5 mm and BOPi+ compared with the MF ≥ 1 per year group (Adjusted OR = 8.23, 95% CI: 2.44, 27.78).ConclusionsThe patients in the severe PCP group were at greater risk of peri‐implant disease than those in the PHP group. In particular, severe PCP who had poor adherence to maintenance care showed a higher incidence of biologic complications.
A cost–utility analysis of decompressive hemicraniectomy versus medical treatment in the management of space‐occupying brain oedema post middle cerebral artery infarction
Authors: Bhattacharyya A. , Tahir A. , Chandrashekar A. , Vasisht S. , Stinson L. , Omatseye J. 
Published: September 2018

Background and purposeData from randomly controlled trials have indicated that a decompressive hemicraniectomy is more clinically effective than medical treatment in the management of space‐occupying brain oedema post middle cerebral artery infarction. This economic evaluation compares the impact of the two options in the UK. No recent study has conducted an economic evaluation on this topic for the UK.MethodA cost–utility analysis over a time period of 1 year was used, measuring benefits in terms of quality adjusted life years (QALYs) and costs in pound sterling, discounted to 2015 prices. The evaluation was from the perspective of the National Health Service, the largest healthcare provider in the UK.ResultsThe cost–utility analysis found an incremental cost effectiveness of £116 595.10 for every QALY gained if patients were offered a decompressive hemicraniectomy compared to the best medical treatment.DiscussionThis is above the National Institute for Health and Care Excellence (NICE) ‘cost‐effective’ threshold of £20 000–£30 000 per QALY, but lower mortality rates associated with the surgical alternative raises ethical considerations for healthcare providers in the UK.
Exercising upper respiratory videoendoscopic findings of 50 competition draught horses with abnormal respiratory noise and/or poor performance
Authors: Hackett E. S. , Leise B. S. 
Published: September 2018

SummaryBackgroundUpper respiratory tract (URT) endoscopy at rest is commonly used to evaluate competition draught horses with URT conditions. Overground endoscopy might be preferred for draught horse URT evaluation as it allows the horses to be driven with harness, overcheck and cart‐load under similar conditions to those experienced in the show ring where airway conditions are most prominent.ObjectiveTo describe the exercising URT findings of competition draught horses with abnormal respiratory noise and/or poor performance.Study designCase series.MethodsMedical records of competition draught horses undergoing overground endoscopic evaluation between January 2013 and January 2018 with a presenting complaint of abnormal respiratory noise and/or poor performance were reviewed. Video recordings of resting and overground endoscopy were evaluated in all horses. Spearman's rank correlation coefficient was calculated between laryngeal function at rest and at exercise.ResultsFifty competition draught horses were examined. Thirteen had previously undergone URT surgery. There was significant correlation between resting and exercising laryngeal function (ρ = 0.77, P<0.01). Abnormalities were detected in 46 horses and included arytenoid cartilage collapse (n = 31), vocal fold collapse (n = 27), palatal dysfunction (n = 14), epiglottic disorders (n = 11), dynamic laryngeal collapse (n = 1), rostral deviation of the palatopharyngeal arch (n = 3) and medial deviation of the aryepiglottic folds (n = 16). The majority of horses had a complex of abnormalities (n = 31) or required exercising examination for identification (n = 41). Incidental upper oesophageal incompetence was observed in nine horses.Main limitationsRetrospective collection of data.ConclusionsOverground endoscopic evaluation was a useful technique for identifying URT disorders in competition draught horses. The spectrum of upper airway conditions identified in exercising draught horses supports the use of overground endoscopy as a diagnostic technique and could influence treatment considerations.
The Summary is available in Portuguese – see Supporting Information