bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trajectories of cold but not mechanical sensitivity correspond with disability trajectories after whiplash injury
Authors: Farrell Scott F. , Armfield Nigel R. , Kristjansson Eythor , Niere Ken , Christensen Steffan Wittrup McPhee , Sterling Michele 
Published: October 2024

Abstract
Developmental trajectories for neck disability after whiplash injury have been identified. Their relationship to cold and mechanical sensitivity trajectories is not known. We aimed to (1) identify recovery trajectories of cold and mechanical sensitivity, (2) explore their codevelopment with disability trajectories, (3) identify predictors of sensitivity trajectories, and (4) explore codevelopment of cold and mechanical sensitivity trajectories. Participants (n = 233) were assessed at <1, 3, 6, and 12 months after whiplash injury. Outcomes were cold pain detection threshold (CPT at neck), pressure pain detection thresholds (PPT, neck C5, and tibialis anterior), and the Neck Disability Index. We used group-based trajectory models to identify postinjury recovery trajectories and multinominal logistic regression to explore associations between baseline characteristics and trajectory membership. We identified the following trajectory groups: CPT (low [50.0%], moderate [29.7%], and high [20.4%] sensitivity); PPT C5 (low [10.8%] and high [89.2%] sensitivity); and PPT tibialis anterior (low [23.9%], moderate [39.0%], and high [37.1%] sensitivity); all were stable over the 12 months. There was good correspondence between disability and cold sensitivity trajectory groups but not for mechanical sensitivity; cold and mechanical sensitivity trajectories were not well associated. Higher baseline pain predicted membership of the high cold sensitivity trajectory (RR 1.27, 95% CI 1.01-1.59) and hyperarousal symptoms predicted membership of the moderate cold sensitivity trajectory (RR 1.17, 95% CI 1.01-1.36). We found no associations between baseline characteristics and mechanical sensitivity. There is an interplay between cold allodynia, pain, and hyperarousal symptoms in development of ongoing disability after whiplash injury. Different mechanisms likely underlie cold and mechanical sensitivity.
Baseline factors associated with myopia progression and axial elongation over 30 months in children 5 to 12 years of age
Authors: Weise Katherine K. , Repka Michael X. , Zhu Yufeng , Manny Ruth E. , Raghuram Aparna , Chandler Danielle L. , Summers Allison I. , Lee Katherine A. , Kehler Lori Ann F. , Pang Yi , Allen Megan S. , Anderson Heather A. , Erzurum S. A. , Golden Richard P. , Koutnik Cassandra A. , Kuo Annie F. , Lenhart Phoebe D. , Mokka Preeti L. , Petersen David B. , Ticho Benjamin H. , Wiecek Emily K. , Yin Huizi , Beaulieu Wesley T. , Kraker Raymond T. , Holmes Jonathan M. , Cotter Susan A. ,   on behalf of the Pediatric Eye Disease Investigator Group
Published: October 2024

PURPOSE
This study aimed to identify baseline factors associated with greater myopia progression and axial elongation in children with myopia.

METHODS
This study performed a post hoc analysis of data from a 30-month randomized trial of atropine 0.01% versus placebo in children 5 to <13 years old with baseline spherical equivalent refractive error (SER) of −1.00 to −6.00 D, astigmatism of ≤1.50 D, and anisometropia of <1.00 D SER. Data from atropine 0.01% and placebo groups were pooled given outcomes were similar. Baseline factors of age, SER, axial length, race, sex, parental myopia, and iris color were evaluated for association with changes in SER and with changes in axial length at 30 months (24 months on treatment and then 6 months off) using backward model selection.

RESULTS
Among 187 randomized participants, 175 (94%) completed 30 months of follow-up. The mean change in SER was greater among younger children (−0.19 D per 1 year younger; 95% confidence interval [CI], −0.25 to −0.14 D; p<0.001) and children with higher myopia (−0.14 D per 1 D more myopia at baseline; 95% CI, −0.23 to −0.05 D; p=0.002). The mean change in axial length was also greater among younger children (0.13 mm per 1 year younger; 95% CI, 0.10 to 0.15 mm; p<0.001) and children with higher baseline myopia (0.04 mm per 1 D more myopia; 95% CI, 0.002 to 0.08; p=0.04).

CONCLUSIONS
Younger children with higher myopia had greater myopic progression and axial elongation over 30 months than older children with lower myopia. Developing effective treatments to slow the faster myopic progression in younger children should be a target of further research.
Molecular and Clinicopathologic Characterization of HER2-overexpressed Squamous Cell Carcinoma of the Cervix
Authors: Mendoza Rachelle P. , Ramineni Madhurya , Doytcheva Kristina , Gabutan Elmer C. , Gupta Raavi , Miller Cole , Choi Donghyuk , Vemuri Anusha , Briese Renee , Brannon Lisa , Shahid Anum , Petras Kristin , Ud Dean Minhaz , Fitzpatrick Carrie , Segal Jeremy , Wang Peng , Lastra Ricardo R. 
Published: October 2024

HER2 amplification in cervical cancer has been associated with worse clinical prognosis and a potential favorable response to HER2 inhibitors. Immunohistochemistry for the HER2 receptor is a universally accepted surrogate test for HER2 amplification, but no standardized scoring system currently exists for cervical carcinomas. In this study, we investigated HER2 overexpression in cervical squamous cell carcinoma and correlated it with HER2 amplification using fluorescence in situ hybridization (FISH) and molecular methods. Seventy-two cases of human papillomavirus-associated cervical cancer were retrospectively reviewed, and at least 2 representative tumor sections were stained for HER2. HER2 scoring was performed using the 2018 American Society of Clinical Oncology/College of American Pathologist breast cancer criteria, and cases with equivocal (2+) to positive (3+) expression were analyzed for HER2 amplification using FISH and next-generation sequencing. The average patient age was 50 yrs (range: 27–85 yr), with most patients being African American (73.6%) and diagnosed at FIGO stage I (65.3%). Nineteen (26.4%) had equivocal HER2 expression and 4 (5.5%) showed positive expression. Three of the 4 cases with positive expression had enough tumors for FISH, and all 3 were amplified. Three cases with equivocal expression showed HER2 polysomy on FISH, and none showed HER2 amplification. Late clinical stage, high tumor grade, and regional lymph node metastasis were significantly correlated with HER2 overexpression and HER2 amplification. Next-generation sequencing of the 3 HER2-amplified tumors showed amplification of various genes, including CD274, JAK2, BIRC3, and ERBB2, and a PIK3CA missense mutation. In summary, HER2 immunohistochemistry is a reliable predictive marker of HER2 amplification in cervical cancer.
Sectorial Hypermetabolic Pseudolesion in the Liver on FDG PET/CT Caused by SVC Obstruction
Authors: Kong Eunjung , Kim Sung Hoon 
Published: October 2024

Abstract
Hepatic pseudolesions are relatively frequent in contrast-enhanced CT or MR images, attributable to the unique intrahepatic hemodynamics. It is also well documented that focal liver uptake can result from unusual collateral circulation on radionuclide liver scans. This report presents a case of sectorial hepatic hypermetabolism identified via FDG PET/CT, correlating with areas of increased attenuation in the liver observed on contrast-enhanced chest CT in a patient with lung cancer complicated by superior vena cava obstruction. Notably, the nonphysiological hypermetabolic activity was resolved on subsequent FDG PET/CT imaging conducted 2 days later, following alteration of the tracer injection route.
Radiation Pneumonitis With 99mTc-MDP Uptake in a Patient With Breast Cancer
Authors: Samadi Mohammad Hadi , Khezri Susan , Rabani Banou Faeze , Bai Mina , Barashki Somaye 
Published: October 2024

Abstract
We present MDP bone scan findings of radiation pneumonitis in a 45-year-old woman with invasive ductal carcinoma of the right breast, classified as stage IIIa, T3N2M0. The patient underwent a modified radical mastectomy, neoadjuvant chemotherapy, and subsequent radiotherapy, receiving the last session 7 months before the bone scan. Whole-body images acquired 3 hours postinjection of 20 mCi (730 MBq) 99mTc-MDP showed incidentally increased uptake in the right hemithorax, confined to the lung parenchyma of the right lung on SPECT/CT images.
Metastatic Lung Adenocarcinoma Presenting Within Struma Ovarii
Authors: Maeng Lee So , Shin Ah Young , Choi Eun Kyoung , Oh Jin Kyoung , Chung Yong-An 
Published: October 2024

Abstract
Tumor-to-tumor metastasis is extremely rare. We herein describe a 67-year-old woman who underwent FDG PET/CT for initial staging of lung cancer. This imaging examination revealed a pelvic mass with peripheral FDG uptake, suggesting a metastatic tumor from lung cancer or a secondary malignancy. Examination of a surgical specimen confirmed metastatic lung adenocarcinoma within a struma ovarii, suggesting tumor-to-tumor metastasis.
Predicting Malignancy in Adnexal Tumors With FAPI PET/CT and FDG PET/CT
Authors: Umachanger Janani Kantharooban , Zacho Helle Damgaard , Sylvest Camilla , Frandsen Anna Poulsgaard , Bentestuen Morten 
Published: October 2024

Abstract
A 54-year-old woman presented with a 55 × 64-mm tumor in the ovary with high [18F]FDG uptake on [18F]FDG PET/CT highly suggestive of ovarian cancer. Prior to surgery, the patient underwent [68Ga]-Ga- fibroblast activation protein inhibitor (FAPI)-46 PET/CT, which revealed low [68Ga]-Ga-FAPI-46 tumor uptake. Histopathology revealed a borderline ovarian tumor, which has low malignant potential and a 10-year survival rate greater than 93%. High [18F]FDG uptake is considered a fair predictor of malignancy in adnexal tumors. The present case demonstrates the potential superiority of [68Ga]-Ga-FAPI-46 PET/CT over [18F]-FDG PET/CT in differentiating malignant adnexal tumors from borderline ovarian tumors.
A Reinforcement Learning-based Approach for Dynamic Privacy Protection in Genomic Data Sharing Beacons
Authors: Aghdam Masoud Poorghaffar , Tabrizi Sobhan Shukueian , Ayöz Kerem , Ayday Erman , Sav Sinem , Çiçek A. Ercüment 
Published: October 2024

AbstractThe rise of genomic sequencing has led to significant privacy concerns due to the sensitive and identifiable nature of genomic data. The Beacon Project, initiated by the Global Alliance for Genomics and Health (GA4GH), was designed to enable privacy-preserving sharing of genomic information via an online querying system. However, studies have revealed that the protocol is vulnerable to membership inference attacks, which can expose the presence of individuals in sensitive datasets. Various countermeasures, such as noise addition and query restrictions, have been proposed but are limited by static implementation, leaving them prone to attackers that can adapt and change strategies. In this study, we present the first reinforcement learning (RL)-based approach for dynamic privacy protection of the beacon protocol. We employ a multi-player RL setting where we train (i) a “Generic-Beacon-Defender” agent who can adjust the honesty rate of its responses, against (ii) a “Generic-Beacon-Attacker” agent who can choose the order of the queries and ask random queries to make the beacon think it is a regular user. This is the first defense mechanism capable of adapting its strategy in real time based on user queries, distinguishing between legitimate users and potential attackers, and applying tailored policies accordingly. By doing so, this method enhances both privacy and utility, effectively countering sophisticated and evolving threats. The code and the models are available atgithub.com/ciceklab/beacon-defense-strategies.
The state of knowledge of freshwater resources in the U.S. Virgin Islands: Data scarcity and implications
Authors: Lancellotti Brittany V. , Hensley David A. 
Published: October 2024

AbstractLike many small island communities, the U.S. Virgin Islands (USVI), an unincorporated territory of the U.S., is naturally freshwater scarce. In recent decades, rapid land development in the USVI has increased water demand considerably, exerting extra pressure on freshwater resources. Freshwater quantity and quality data for the USVI are very scarce and scattered, which limits freshwater management capabilities. We draw attention to this information deficit and discuss its implications by reviewing the current state of knowledge of surface and groundwater quantity and quality for the USVI. Our review confirms that long‐term records of surface and groundwater quantity and quality are limited and unreliable. For example, streamflow was most recently monitored in 2006, and the most extensive surface water quality records are from the 1960s and 1980s. Since 2016, mean groundwater levels have been recorded daily, but only for three wells (one on each island of the USVI). Importantly, this lack of information threatens water security for the territory and limits our understanding of how development has impacted water quality and availability over time. This could be addressed using models, such as a groundwater recharge model, in combination with remote sensing and updated field data (i.e., streamflow, groundwater, and ecohydrological characterizations of land use change).
Biliopancreatic limb obstruction after one‐anastomosis gastric bypass; a very rare and fatal event: A case report and literature review
Authors: Athar Rahmatullah , Khalaj Alireza , Shapori Parvin 
Published: October 2024

AbstractThe biliopancreatic limb (BPL) obstruction occurrence after one‐anastomosis gastric bypass (OAGB) has not been well described in the literature. A 65‐year‐old female with a history of OAGB surgery presented with acute weight loss and abdominal pain. Imaging studies revealed a bezoar in the duodenal diverticulum obstructing the small bowel. An urgent laparoscopic intervention was performed to remove the bezoar and alleviate the obstruction. The patient experienced postoperative complications, including gastrostomy drainage and subsequent biliobezoar migration. additional surgeries were required to address these complications. This is a rare condition, and it is usually seen in patients with predisposing factors like DM, previous surgery, and duodenal diverticulum. CT scan study is the useful diagnostic modality, and laparoscopic intervention is the choice treatment; this case highlights the importance of recognizing and managing bezoars as a potential complication following bariatric surgery.
Social media‐enabled crisis response in Vietnam: A tương thân tương ái perspective
Authors: Qi Hailun , Xu Linna , Pan Shan L. , Du Wenyu (Derek) 
Published: October 2024

AbstractA growing amount of information systems (IS) research is examining the use of social media to enable effective crisis response. However, existing studies have overlooked the impact of indigenous concepts, which play an important role in crisis response. Our study intends to offer an indigenous perspective to this research stream by examining how social media‐enabled crisis response is enacted in Vietnam. We used COVID‐19 as the focal crisis and collected a rich set of discussion threads from social media. By analysing the data through the grounded theory method, our study identifies the indigenous theoretical concept of tương thân tương ái. We further unveil a process model consisting of six mechanisms through which tương thân tương ái inspires crisis response on social media and three roles assumed by social media during this process. Our study contributes to the literature on social media‐enabled crisis response by providing an indigenous perspective and a context‐specific explanation. It also enriches IS theory in the Association of Southeast Asian Nations (ASEAN) by investigating how the indigenous concept of tương thân tương ái influences Vietnam's crisis response on social media. Our findings also provide guidelines that can help communities beyond Vietnam to promote the values of tương thân tương ái during crisis response.
Decolonizing IS through tecnologia social: Fostering epistemic plurality in the design of solidarity cryptocurrency in Latin America
Authors: Sanches Bruno Henrique , Pozzebon Marlei , Diniz Eduardo Henrique 
Published: October 2024

AbstractWesternised paradigms dominate the information systems (IS) field, often overshadowing alternative epistemologies. This study challenges the prevailing hegemonic view and contributes to the decolonization of IS research and practice by proposing a Latin American and decolonial approach to technological development that emphasises community centrality and epistemic justice through recognition of local knowledges and Indigenous traditions. Using design ethnography, we follow the development of a solidarity cryptocurrency in a Brazilian favela. Our paper offers two key contributions. By introducing tecnologia social, an underrepresented perspective in IS, we highlight ecology of knowledges, centrality of the local and decolonial reconfiguration as principles that can enrich the understanding of IS projects from a decolonial perspective. In addition, we propose a new concept—epistemic dialogical tension—as a process wherein different epistemologies coexist and accommodate each other, encouraging a dynamic interplay of distinct human experiences and worldviews. It offers new paths to IS scholars and practitioners in navigating the complexities of epistemic plurality. We argue that tecnologia social and epistemic dialogical tension provide fertile ground for developing reimagined, decolonized approaches where multiple epistemologies can coexist, favouring the often‐silenced communities they are intended to benefit.
Financial Sustainability Above All Else? Drivers and Types of Pension Reform Recommendations in EU Socio‐economic Governance
Authors: Helmdag Jan , Väänänen Niko 
Published: October 2024

AbstractThe average age of the population and the ratio of workers to pensioners in the European Union (EU) are rising, putting increasing pressure on the long‐term sustainability of pension systems. To counteract this development, a large number of pension reform recommendations (PRRs) have been issued within EU socio‐economic governance. In this article, we analyse the extent to which PRRs are consistent with the three main objectives of the open method of coordination (OMC), which emphasise (i) financial sustainability, (ii) benefit adequacy and (iii) modernisation with respect to gender equality. Using an original dataset, we code 438 PRRs from 2011 to 2023 and analyse the extent to which these are consistent with the three main objectives of the OMC. Our results show that PRRs are primarily focused on financial sustainability, to the detriment of adequacy and modernisation, and that they are driven solely by sustainability concerns.
Accuracy of intraoral versus desktop scanners used in digitizing polyvinyl siloxane impression for fabricating a CAD‐CAM customized post and core
Authors: Cui Xinyue , Liu Yushu , Zhang Rui , Wang Xinzhi 
Published: October 2024

AbstractPurposeThis in vitro study aimed to compare the 3‐dimensional (3D) accuracy of intraoral and desktop scanners when digitizing the post and core polyvinyl siloxane impressions.Material and MethodsTen extracted human teeth were prepared to build a post space in the root canal. Each tooth was scanned using a micro‐computed tomography device (MCT), and the slice data were reconstructed as controls. A conventional quadrant polyvinyl siloxane impression was made and scanned thrice using an intraoral scanner (IOS) and a desktop blue‐light scanner (IMS), with one of the scans randomly selected as the definitive cast. Precision was assessed by comparing the deviations among repeated scans. Trueness was evaluated by analyzing the deviations between the MCT and each definitive cast (MCT‐IOS and MCT‐IMS). The clinically acceptable root mean square (RMS) value was set to 50 µm.ResultsThe mean RMS values of the repeated scans of IOS and IMS were 18.3 ± 3.9 µm and 13.9 ± 6.2 µm (P < 0.05), and the difference between them was 4.4 ± 5.9 µm. The mean RMS values of MCT‐IOS and MCT‐IMS were 28.3 ±3.0 µm and 31.3 ± 4.2 µm (P < 0.05), with a difference of 3.0 ± 2.9 µm. The RMS values were significantly lower than 50 µm (P < 0.05).ConclusionsThe IOS showed slightly better trueness than the IMS but slightly lower precision. The precision and trueness of the two scanners for digitizing post and core impressions were acceptable for clinical application.
The impact of apple cider vinegar on nonalcoholic fatty liver disease in rainbow trout, Oncorhynchus mykiss: A study of therapeutic potential and health benefits
Authors: Asadi Salimeh , Ahmadniaye Motlagh Hamidreza , Safari Omid , Javadmanesh Ali 
Published: October 2024

AbstractIn this study, we aimed to experimentally induce fatty liver disease in rainbow trout, Oncorhynchus mykiss, and then assessed the illness recovery process, growth, and changes in the expression of FAAH and ACADL genes in both healthy (0 [C2] and 4% apple cider vinegar [T4]) and diseased fish (0 [C1], 1 [T1], 2 [T2], and 4% [T3]) apple cider vinegar. To conduct the study, 180 rainbow trout were randomly assigned to six different experimental treatments, each with three replications. The investigation lasted for 60 days. Growth indices, liver histology, blood biochemical parameters, and transcription of the ACADL and FAAH genes in the liver tissue were measured. The study found no significant differences in the final weights across all the treatments. Apple cider vinegar (ACV) administration resulted in a decrease in AST, ALT, and ALP; however, these values did not show a significant difference from C2. In T3, triglycerides significantly decreased (p < 0.05), whereas in T4, triglycerides significantly increased (p < 0.05). Hepatocytes from ACV‐containing treatments showed reduced fat compared with T4 and the control group (C1). While there was a significant difference (p < 0.05) in the expression of the FAAH gene, there was no significant difference (p > 0.05) in the expression of the ACADL gene between experimental treatments. The findings of our study indicate that an inclusion of up to 2% ACV may have positive effects on trout aquaculture and NAFLD treatment.
Securing commitment and control for the supply of plasma derivatives for public health systems. I: A short review of the global landscape
Authors: von Bonsdorff Leni , Farrugia Albert , Candura Fabio , O'Leary Peter , Vesga Miguel A. , De Angelis Vincenzo 
Published: October 2024

AbstractThe social market economies of the Western world considered the provision of plasma derivatives produced from publicly owned blood services as a legitimate state commitment and, until the last decades of the 20th century, many of the relevant jurisdictions maintained state‐supported fractionation plants to convert publicly collected plasma into products for the public health system. This situation started to change in the 1990s, because of several converging factors, and currently, publicly owned/subsidized, not‐for‐profit fractionation activity has shrunk to a handful of players. However, the collection of plasma from publicly owned blood services has continued and recent developments have increased the interest of state authorities globally to increase the volume of plasma collected to increase the level of strategic independence in the supply of crucial plasma‐derived medicines from commercial market pressures, particularly the global for‐profit fractionation sector with its dominance of source plasma from paid donors in the United States. This paper reviews the development of the plasma industry and the evolution of the pressures on the supply of plasma, which has led to a situation of scarcity of key plasma‐derived medicinal products (PDMPs).