bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non-coding RNA H19 promotes corneal neovascularization by targeting microRNA-29c
Authors: Sun Baoqi , Ding Yiheng , Jin Xin , Xu Shuo , Zhang Hong 
Published: April 2019

Abstract
Long non-coding RNA (lncRNA) H19 has been implicated in tumor angiogenesis. However, whether H19 regulates the progression of corneal neovascularization (CNV) is unclear. The present study aimed to determine the function of H19 in CNV and its possible molecular mechanism. Here, we found that the H19 levels were remarkably increased in vascularized corneas and basic fibroblast growth factor (bFGF)-treated human umbilical vein endothelial cells (HUVECs). In vitro, H19 up-regulation promoted proliferation, migration, tube formation and vascular endothelial growth factor A (VEGFA) expression in HUVECs, and it was found to down-regulate microRNA-29c (miR-29c) expression. Bioinformatics analysis revealed that H19 mediated the above effects by binding directly to miR-29c. In addition, miR-29c expression was markedly reduced in vascularized corneas and its expression also decreased in bFGF-treated HUVECs in vitro. MiR-29c targeted the 3′ untranslated region (3′-UTR) of VEGFA and decreased its expression. These data suggest that H19 can enhance CNV progression by inhibiting miR-29c, which negatively regulates VEGFA. This novel regulatory axis may serve as a potential therapeutic target for CNV.
Gender Differences in the Narrative Productions of African American Adults
Authors: Bradford Wainwright Angela 
Published: April 2019

Purpose
The narrative is an important component of cognitive–linguistic assessment of nonmainstream populations and provides a valuable basis on which to conduct cross-ethnic/cultural comparisons. Given that there is limited information on the narrative characteristics of African American adults, this study was designed to describe the nature of narrative productions among African American men and women and to determine if gender differences exist in those productions.

Method
Seventy-six African American adults—40 women (ages 46–86 years) and 36 men (ages 45–87 years)—recruited from Washington, DC, and the Metropolitan area took part in the study. Participants produced a complex story retelling and a personal narrative of their choosing. All narratives were transcribed orthographically, parsed into T-units, and analyzed for narrative superstructure. Narratives were then examined by establishing the quantity of information, distribution of information, and African American English (AAE) density and usage.

Results
The results of the study demonstrated that women produced more information across all measures of quantity and narrative conditions. Gender differences were observed where men produced narratives that were brief and succinct whereas women produced longer, more elaborative narratives. Moreover, women produced more information across constituent units of the narratives. Although the use of AAE and its effect on quantity and distribution of information were negligible, the results demonstrated that men produced more occurrences of AAE than women.

Conclusions
This study demonstrated that women were more talkative, produced more information, took more time to produce their narratives, and told stories that were more descriptive, evaluative, and reflective than those of their male counterparts. This study also suggests that personal narratives may be more robust in characterizing the process of African American adult narrative production whereas story retelling may be a good contrastive element in further describing narrativization.

Supplemental Material

https://doi.org/10.23641/asha.7905377
Time and frequency transfer using BDS‐2 and BDS‐3 carrier‐phase observations
Authors: Zhang Pengfei , Tu Rui , Zhang Rui , Liu Na , Gao Yuping 
Published: April 2019

The experimental satellite of the third generation BeiDou navigation satellite system (BDS‐3e) is a significant step towards expanding the current regional BDS‐2 into a global satellite navigation system. These satellites are equipped with new atomic clocks and the application of time and frequency transfer is therefore important. In this study, carrier phase observations from BDS‐3e and BDS‐2 satellites were employed in time and frequency transfer. Experiments with two schemes were designed to assess the time and frequency transfer performance. BDS‐3e increased the number of available satellites, and the corresponding time dilution of precision (TDOP) was improved. Therefore, the accuracy of receiver clock offset is improved, and the noise level of time links with BDS‐3e is also improved compared to using only the BDS‐2 constellation. The range was 4.2% for the CEDU‐KAT1 time link. However, because fewer satellites are available and the corresponding accuracy of satellite tracking geometry is low for the HOB2‐KAT1 time link, the above‐mentioned improvement was not apparent. In terms of the frequency stability, the CEDU‐KAT1 time link using the BDS‐3 solution showed an improvement of approximately 12.3% compared to using only the BDS‐2 solution when the averaging time intervals were within 1000 s.
Potential of temperature-response collagen-genipin sols as a novel submucosal injection material for endoscopic resection
Authors: Takatori Yusaku , Uraoka Toshio , Narita Takefumi , Yunoki Shunji , Yahagi Naohisa 
Published: April 2019

Abstract
Background and study aims We developed a novel submucosal (SM) injection material that contained pepsin-solubilized collagen (PSC), genipin (Ge) and phosphate buffer (PB). The aim of this study was to validate safety and usability of it for endoscopic resection (ER).
Materials and methods In preliminary studies, 1) appropriate warming time and concentration of Ge, and concentration of NaCl in PB, 2) storage modulus of PSC, Ge, and PB mixture (PSC/Ge), and PSC as a mechanical property, 3) histological finding after injection, and histological toxicity of PSC/Ge was evaluated. We injected PSC/Ge, PSC, sodium hyaluronate (SH), dextrose (DW), and normal saline (NS) into SM of resected porcine stomach. We compared mean height of mucosal elevation after immediate injection (MH) and mean retaining rate at 60 minutes (MR) as ex vivo study.
Results Optimal condition of PSC/Ge was Ge 5.5 mMol with 24 hours worming time and NaCl 280 mMol. PSC/Ge had better mechanical property than PSC. It was efficiently integrated and confined to the SM with acceptable toxicity. MH of PSC/Ge (5.1 ± 0.74 mm) and PSC (4.8 ± 0.84 mm) were significantly higher than NS (3.2 ± 0.84 mm). MR of PSC/Ge (100 ± 0.0%) was significantly higher than NS (61.7 ± 11.2%), DW (58.3 ± 11.8%) and SH (61.8 ± 8.6%).
Conclusion PSC/Ge and PSC has potential to be safe and usable for ER. PSC/Ge was better than PSC because of better mechanical property than PSC.
Relationship between endoscopic mucosal healing and histologic inflammation during remission maintenance phase in ulcerative colitis: a retrospective study
Authors: Kanazawa Mimari , Takahashi Fumiaki , Tominaga Keiichi , Abe Keiichiro , Izawa Naoya , Fukushi Koh , Nagashima Kazunori , Kanamori Akira , Takenaka Kazuhiro , Sugaya Takeshi , Iijima Makoto , Takada Atsuko , Imai Yasuo , Hiraishi Hideyuki , Irisawa Atsushi 
Published: April 2019

Abstract
Background and study aims Recently, histological inflammation has been suggested to be an important predictor of sustained remission or relapse of ulcerative colitis (UC). In this study, we retrospectively compared severity of histological inflammation with endoscopic findings in UC patients with mucosal healing (MH) in the remission maintenance phase, and investigated whether histological healing could be a predictor of sustained remission.
Patients and methods This study included 166 patients with MH in the remission maintenance phase. Endoscopic evaluation was based on the Mayo endoscopic subscore (MES), and MH was defined as MES 0 or 1. Severity of histological inflammation was graded according to the Matts classification. Patients with Matts 1 and 2 were included in the histological healing (HH) group, and those with Matts 3, 4, and 5, in the non-histological healing (NHH) group. In patients with MH, incidence of relapse was compared and analyzed according to severity of histological inflammation.
Results The remission maintenance rate was significantly higher in the MES 0 group than in the MES 1 group (P = 0.004). The rate was significantly higher in the HH group than in the NHH group (P = 0.003). Within the MES 1 group, the rate was significantly higher in the HH subgroup than in the NHH subgroup (P = 0.030).
Conclusions This retrospective study suggests that histological healing can be a predictor of sustained remission in UC patients, and examination of histological inflammation provides useful information for long-term management of UC, particularly in patients with MES 1.
Perspectives in Gamete and Embryo Cryopreservation
Authors: Rienzi Laura , Iussig Benedetta , Dovere Lisa , Fabozzi Gemma , Cimadomo Danilo , Ubaldi Filippo 
Published: April 2019

AbstractCryopreserved gametes and embryos are a major feature of human-assisted reproduction and patient care services, accounting for an increasing number of births worldwide. Since the first success obtained using frozen human spermatozoa, cryopreservation technology has been successfully extended to include oocytes and embryos, in a variety of both medical and nonmedical indications. Over the years, the available procedures have become widely implemented and the increasing evidence of its efficacy has contributed to acceptance of the technology. Nevertheless, a gold standard protocol that would be universally shared by clinics has yet to be definitively established and, therefore, research into cryopreservation of gametes and embryos cannot be considered concluded. Moreover, much effort should be committed to the definition and resolution of safety issues, the establishment of automation, and investigations about the potentiality of immature germ cells or stem cells.
Severe Anemia Is Associated with Intestinal Injury in Preterm Neonates
Authors: Ozcan Beyza , Aydemir Ozge , Isik Dilek Ulubas , Bas Ahmet Yagmur , Demirel Nihal 
Published: April 2019

Abstract
Objective A temporal relationship has been reported between necrotizing enterocolitis, anemia, and red blood cell transfusion (RBCT) in preterm neonates. However, the mechanism underlying this association is not clearly defined. Intestinal (I-) and liver (L-) fatty acid binding proteins (FABPs) have been proposed as plasma markers for the detection of acute intestinal injury. This study aimed to investigate the effect of anemia and RBCT on intestinal injury in preterm neonates by measuring serum I-FABP and L-FABP levels.
Study Design A prospective cohort study including preterm neonates with gestational age <32 weeks and/or birth weight <1,500 g and requiring erythrocyte transfusions for anemia after day 15 of life was conducted. Stable growing preterm infants with hemoglobin values ≥ 10 g/dL were taken as controls. I-FABP and L-FABP levels of the neonates with anemia were compared with levels of the control group. In addition, pretransfusion I-FABP and L-FABP levels of the neonates with anemia were compared with posttransfusion levels.
Results In total, 39 infants transfused for anemia and 20 controls were enrolled. L-FABP levels were significantly higher in neonates with anemia compared with controls (p < 0.001), whereas I-FABP (p = 0.695) was not different. L-FABP and I-FABP levels were similar before and after transfusion in neonates with anemia. L-FABP levels before transfusion were negatively correlated with pretransfusion hemoglobin levels (p < 0.001).
Conclusion Anemia is associated with intestinal injury documented by increased L-FABP levels in preterm infants, and this injury is more severe with lower hemoglobin levels.
Molecular design of self-coacervation phenomena in block polyampholytes
Authors: Danielsen Scott P. O. , McCarty James , Shea Joan-Emma , Delaney Kris T. , Fredrickson Glenn H. 
Published: April 2019

Significance
By combining field-theoretic simulations and molecular-dynamics simulations, we show how the charge sequence of block polyampholytes affects their solution-phase behavior and accessible chain conformations. We find a striking effect of like charge block length and connectivity on their self-coacervation or liquid–liquid phase separation. Charge patterning on smaller lengthscales allows for more expanded chain configurations and increased stability in dilute solution. These findings may provide insight into the condensation of intrinsically disordered proteins in vivo.
Interlingual transfer of social media terminology
Authors: Ortego-Antón María-Teresa , Pimentel Janine 
Published: April 2019

AbstractThis article addresses the terminology used in the field of social media, a new field introduced by recent technological advances. As social media was first created in an English-speaking context, speakers of other languages have had to develop ways to express the concepts of this field in their own languages. It is thus relevant for translators and journalists to understand the linguistic means by which the transfer of such concepts occurs. In order to achieve this, a comparable corpus of newspaper articles on social media (Facebook and WhatsApp) written in English, Spanish and Brazilian Portuguese was compiled and the procedures used by Brazilian Portuguese and Spanish journalists to convey frequently-used English terms were examined. The main translation procedures observed in the study are equivalence, calque, loan and paraphrase. Although most procedures occur in the texts written in both Spanish and Brazilian Portuguese, their frequency of use indicates linguistic preferences in the languages.
Alternative analyses of compensatory base changes in an ITS2 phylogeny of Corydalis (Papaveraceae)
Authors: Li Meihui , Zhao Hong , Zhao Fengxi , Jiang Lu , Peng Huasheng , Zhang Wei , Simmons Mark P 
Published: April 2019

AbstractBackground and AimsCompensatory base changes (CBCs) that occur in stems of ribosomal internal transcribed spacer 2 (ITS2) can have important phylogenetic implications because they are not expected to occur within a single species and also affect selection of appropriate DNA substitution models. These effects have been demonstrated when studying ancient lineages. Here we examine these effects to quantify their importance within a more recent lineage by using both DNA- and RNA-specific models.MethodsWe examined the phylogenetic implications of the CBC process by using a comprehensive sampling of ITS2 from ten closely related species of Corydalis. We predicted ITS2 secondary structures by using homology modelling, which was then used for a structure-based alignment. Paired and unpaired regions were analysed separately and in combination by using both RNA-specific substitution models and conventional DNA models. We mapped all base-pair states of CBCs on the phylogenetic tree to infer their evolution and relative timing.Key ResultsOur results indicate that selection acted to increase the thermodynamic stability of the secondary structure. Thus, the unpaired and paired regions did not evolve under a common substitution model. Only two CBCs occurred within the lineage sampled and no striking differences in topology or support for the shared clades were found between trees constructed using DNA- or RNA-specific substitution models.ConclusionsAlthough application of RNA-specific substitution models remains preferred over more conventional DNA models, we infer that application of conventional DNA models is unlikely to be problematic when conducting phylogenetic analyses of ITS2 within closely related lineages wherein few CBCs are observed. Each of the two CBCs was found within the same lineages but was not observed within a given species, which supports application of the CBC species concept.
Paranasal Augmentation Using Multi-Folded Expanded Polytetrafluorethylene (ePTFE) in the East Asian Nose
Authors: Lee Tae-Yul , Chung Ha-Yoon , Dhong Eun-Sang , Jeong Seong-Ho , Han Seung-Kyu 
Published: April 2019

Abstract

Background
Paranasal augmentation has commonly been performed utilizing alloplastic materials such as silicone or porous polyethylene. However, there are problems such as bone absorption, implant migration, and infection risk attributable to intraoral approaches.

Objectives
The authors attempted anterior positioning of the alar crease junction as an adjunct method of rhinoplasty. The authors aimed to determine the long-term results of the intranasal approach for placement of multi-folded expanded polytetrafluorethylene (ePTFE).

Methods
A retrospective review was conducted of patients who underwent intranasal surgical approach for paranasal augmentation employing multi-folded ePTFE implants in 19 septorhinoplasties who were followed-up for 3 to 10 years. Patient charts were reviewed for demographic information, concomitant operations, and complications. Preoperative and postoperative photographs were utilized to evaluate operative outcomes. The photographs were reformatted to 2-dimensional images employing standard photographic methods.

Results
Of the 19 patients treated, 17 were female and 2 were male; ages ranged from 18 to 58 years. All patients reported improvement in their lateral profiles and were pleased at follow-up. There were no major complications, no nerve or vascular supply compromise, and no cases of implant malposition. The average increase in soft tissue outline near the alar crease junction was more than 3.2 mm (P &lt; 0.001), but the alar base did not became wider.

Conclusions
Paranasal augmentation with multi-folded ePTFE is a simple, safe, and effective method that can readily improve the lateral profile. In particular, the intranasal approach combined with rhinoplasty can synergistically improve outcomes and lead to greater patient satisfaction.

Level of Evidence: 4
Consistent gene signature of schizophrenia identified by a novel feature selection strategy from comprehensive sets of transcriptomic data
Authors: Yang Qingxia , Li Bo , Tang Jing , Cui Xuejiao , Wang Yunxia , Li Xiaofeng , Hu Jie , Chen Yuzong , Xue Weiwei , Lou Yan , Qiu Yunqing , Zhu Feng 
Published: April 2019

Abstract
The etiology of schizophrenia (SCZ) is regarded as one of the most fundamental puzzles in current medical research, and its diagnosis is limited by the lack of objective molecular criteria. Although plenty of studies were conducted, SCZ gene signatures identified by these independent studies are found highly inconsistent. As one of the most important factors contributing to this inconsistency, the feature selection methods used currently do not fully consider the reproducibility among the signatures discovered from different datasets. Therefore, it is crucial to develop new bioinformatics tools of novel strategy for ensuring a stable discovery of gene signature for SCZ. In this study, a novel feature selection strategy (1) integrating repeated random sampling with consensus scoring and (2) evaluating the consistency of gene rank among different datasets was constructed. By systematically assessing the identified SCZ signature comprising 135 differentially expressed genes, this newly constructed strategy demonstrated significantly enhanced stability and better differentiating ability compared with the feature selection methods popular in current SCZ research. Based on a first-ever assessment on methods’ reproducibility cross-validated by independent datasets from three representative studies, the new strategy stood out among the popular methods by showing superior stability and differentiating ability. Finally, 2 novel and 17 previously reported transcription factors were identified and showed great potential in revealing the etiology of SCZ. In sum, the SCZ signature identified in this study would provide valuable clues for discovering diagnostic molecules and potential targets for SCZ.
Double Auction for a Data Trading Market with Preferences and Conflicts of Interest
Authors: Cai Hui , Zhu Yanmin , Li Jie , Yu Jiadi 
Published: April 2019

Abstract
The advent of big data era has given rise to the big data trading market because of the potentially enormous economic value. However, designing an effective trading mechanism for the data trading market is still in its infancy. Existing several incentive mechanisms have neglected the important fact that data consumers have both preferences and complex conflicts of interest (CoI) relations among them. In response to the limitations of existing trading mechanisms, we propose DTPCI, a truthful double auction mechanism for a Data Trading market with two unique characteristics of consumers’ Preferences and complex CoI relations among them. However, three major challenges have to be addressed, i.e. diverse market preferences, the complex CoI relations of data consumers and the strategic behaviors of both two sides. To jointly address the three challenges, we propose DTPCI to achieve nonnegative social welfare, which features a group rule and a data trading rule. The group rule generates all conflict-free virtual groups based on the CoI graph. The data trading rule adopts the group buying to share data and expense. Through rigorous theoretical analysis and real-data based experiments, we demonstrate that DTPCI achieves all the desired economic properties.
Ovarian cancer suspicion, urgent referral and time to diagnosis in Danish general practice: a population-based study
Authors: Baun Marie-Louise L , Jensen Henry , Falborg Alina Z , Heje Hanne N , Petersen Lone K , Vedsted Peter 
Published: April 2019

Abstract

Background
Ovarian cancer (OC) survival rates are lower in Denmark than in countries with similar health care. Prolonged time to diagnosis could be a contributing factor. The Danish cancer patient pathway (CPP) for OC was introduced in 2009. It provides GPs with fast access to diagnostic work-up.

Objective
To investigate cancer suspicion and pathway use among GPs and to explore the association between these factors and the diagnostic intervals (DIs).

Methods
We conducted a national population-based cohort study using questionnaires and national registers.

Results
Of the 313 women with participating GPs, 91% presented with symptoms within 1 year of diagnosis, 61% presented vague non-specific symptoms and 62% were diagnosed with late-stage disease. Cancer was suspected in 39%, and 36% were referred to a CPP. Comorbidity [prevalence ratio (PR): 0.53, 95% confidence interval (CI): 0.29–0.98] and no cancer suspicion (PR: 0.35, 95% CI: 0.20–0.60) were associated with no referral to a CPP. The median DI was 36 days. Long DIs were associated with no cancer suspicion (median DI: 59 versus 20 days) and no referral to a CPP (median DI: 42 versus 23 days).

Conclusions
Nine in ten patients attended general practice with symptoms before diagnosis. Two-thirds initially presented with vague non-specific symptoms were less likely to be referred to a CPP and had longer DIs than women suspected of cancer. These findings underline the importance of supplementing the CPP with additional accelerated diagnostic routes.