bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of cardiac and skeletal muscle metabolites using 1H‐MRS and chemical‐shift encoded magnetic resonance imaging: Impact of diabetes, RAGE, and DIAPH1
Authors: Menon Rajiv G. , Yepuri Gautham , Martel Dimitri , Quadri Nosirudeen , Hasan Syed Nurul , Manigrasso Michaele B. , Shekhtman Alexander , Schmidt Ann Marie , Ramasamy Ravichandran , Regatte Ravinder R. 
Published: October 2024

AbstractDiabetes affects metabolism and metabolite concentrations in multiple organs. Previous preclinical studies have shown that receptor for advanced glycation end products (RAGE, gene symbol Ager) and its cytoplasmic domain binding partner, Diaphanous‐1 (DIAPH1), are key mediators of diabetic micro‐ and macro‐vascular complications. In this study, we used 1H‐Magnetic Resonance Spectroscopy (MRS) and chemical shift encoded (CSE) Magnetic Resonance Imaging (MRI) to investigate the metabolite and water‐fat fraction in the heart and hind limb muscle in a murine model of type 1 diabetes (T1D) and to determine if the metabolite changes in the heart and hind limb are influenced by (a) deletion of Ager or Diaph1 and (b) pharmacological blockade of RAGE‐DIAPH1 interaction in mice. Nine cohorts of male mice, with six mice per cohort, were used: wild type non‐diabetic control mice (WT‐NDM), WT‐diabetic (WT‐DM) mice, Ager knockout non‐diabetic (RKO‐NDM) and diabetic mice (RKO‐DM), Diaph1 knockout non‐diabetic (DKO‐NDM), and diabetic mice (DKO‐DM), WT‐NDM mice treated with vehicle, WT‐DM mice treated with vehicle, and WT‐DM mice treated with RAGE229 (antagonist of RAGE‐DIAPH1 interaction). A Point Resolved Spectroscopy (PRESS) sequence for 1H‐MRS, and multi‐echo gradient recalled echo (GRE) for CSE were employed. Triglycerides, and free fatty acids in the heart and hind limb obtained from MRS and MRI were compared to those measured using biochemical assays. Two‐sided t‐test, non‐parametric Kruskal‐Wallis Test, and one‐way ANOVA were employed for statistical analysis. We report that the results were well‐correlated with significant differences using MRI and biochemical assays between WT‐NDM and WT‐DM, as well as within the non‐diabetic groups, and within the diabetic groups. Deletion of Ager or Diaph1, or treatment with RAGE229 attenuated diabetes‐associated increases in triglycerides in the heart and hind limb in mice. These results suggest that the employment of 1H‐MRS/MRI is a feasible non‐invasive modality to monitor metabolic dysfunction in T1D and the metabolic consequences of interventions that block RAGE and DIAPH1.
Research on cyberbullying and suicide: a bibliometric analysis
Authors: Denche‐Zamorano A. , Mendoza‐Muñoz M. , Barrios‐Fernández S. , Galán‐Arroyo C. , Adsuar J. C. , y Rojo‐Ramos J. 
Published: October 2024

AbstractSuicide is a global mental health problem. In recent years, suicidal ideation, suicide attempts and suicides have increased in children and adolescents. In this population, cyberbullying is a public health problem that has grown along the increase in use of devices with internet access. Cybervictimization is related to negative health effects, even including suicidal ideation or suicide in cyberbullied individuals. This study is the first bibliometric analysis on scientific literature related to cyberbullying and suicide based on the traditional laws of bibliometrics. The aim was to generate a global overview of the research related to this object of study. We analysed 242 documents published in journals indexed in the Web of Science, examining the trend followed by annual publications, identifying the prolific (most productive) and prominent (prolific co‐authors with one or more papers between most cited papers) co‐authors, leading countries and journals, the most cited documents and the most used author keywords. Annual publications followed an exponential growth trend (R2 = 89.2%), meaning that there is a great interest in the scientific community for this study object. International Journal of Environmental Research and Public Health and Psychiatry Research were the journals with most document published. Baiden, P. (prolific), Kowalski, R. (most cited), Hinjuja, S. and Patchin, J. (prominents) were the most highlighted co‐authors, reference authors on the subject. Most scientific output originated in the USA. Five thematic lines were identified among the author keywords. The results of this research show the growing interest of the scientific community in this topic, along with useful information for researchers and publishers, identifying relevant co‐authors, journals interested in the topic and emerging lines of research, highlighting self‐harm, cyber‐victimisation, suicide risks and suicidal behaviours as the most recent thematic lines.
Profiles of John Henryism and subjective task value in higher education: the motivations and attributions of nontraditional students
Authors: Eisman Joseph I. , Torsney Benjamin M. , Beckowski Catherine Pressimone , Reinhardt Jessica S. 
Published: October 2024

AbstractSchool psychology scholars argue that diversifying the profession will advance equity and social justice. Yet, nontraditional and racially and ethnically minoritized students are underrepresented in school psychology programs. These diverse college students bring complex identities that may complicate as well as enrich their paths to achievement. This is a challenge as higher education environments often do not optimize support for these students. To address this challenge, we investigated the influence of a school‐based task on cognitive engagement, subjective task value, positive and negative emotions, identities, and context‐sensitive high‐effort coping called John Henryism in 294 U.S. college students. Correlation and regression analysis demonstrated a strong relationship between John Henryism and subjective task value. Latent profile analysis and follow‐up logistic regression demonstrated that older and Latinx students predicted membership in the group that was high in John Henryism and subjective task value. We discuss theoretical and practical implications of this work in better understanding the mixed consequences of achievement motivation, contextualizing subjective task value using John Henryism, and recommendations for higher education institutions.
Stress, social support, and internalizing problems: Domains of stress and support
Authors: Wimmer Jessica , Coyle‐Eastwick Samantha , Fox Jeremy K. , Grapin Sally 
Published: October 2024

AbstractSocial support has been consistently identified as a protective factor for youth. Two competing models have been proposed regarding the role of social support: one in which social support provides benefits for all youth (General Benefits) and one where youth undergoing stress are especially protected (Stress‐Buffering). While the General Benefits model is supported, evidence for Stress‐Buffering is more mixed. These disparate findings may be attributed to how different sources of social support (i.e., parents, teachers, classmates, and friends) interact with different stressors in relation to internalizing problems. The current study investigated the relationships between different stressors (i.e., family, academic, and social), sources of social support, and internalizing problems in a sample of 166 middle school students. The General Benefits model was supported for all sources of social support. Surprisingly, vulnerability‐enhancing effects were found for high teacher and parent support, wherein the positive association between internalizing problems and social stress was strengthened with high teacher and parent support.
Incidence, characteristics, and clinical impact of serious adverse events in patients with breast cancer receiving antineoplastic treatment in the ambulatory setting
Authors: AbuAloush Zahieh , Awad Wedad , Mashni Ola , Shkakhwa Farah , Al‐Faris Ayman , Al‐Omari Maryam , Nabulsi Sara , Nazer Lama 
Published: October 2024

AbstractPatients with breast cancer experience various types of adverse events (AEs) during their treatment journey. We aimed to evaluate the incidence, characteristics, and impact of serious AEs in breast cancer patients receiving antineoplastic treatment in the ambulatory setting. A 4‐month prospective observational study that included patients with breast cancer treated in the chemotherapy infusion clinics. Patients were assessed for serious AEs, defined as any AE that resulted in a visit to the emergency department (ED) with or without hospital admission, or required any clinical intervention, which were considered as the addition of supportive medications or modifications to the treatment protocol. Characteristics of the patients and antineoplastic regimens as well as the type of AEs were recorded. During the study period, 1168 patients received 2547 cycles. The mean age was 50 ± 11.6 (SD) years and patients had received a median (IQR) of 3 (1–5) treatment cycles prior to enrollment. Among the study cohort, 465 patients(40%) developed at least one serious AE. A total of 660 (26%) cycles were associated with 757 AEs, which required ED visits, addition of supportive medications, and modifications to the treatment protocol in 58%, 29%, and 17% of the cycles, respectively. Most common AEs were musculoskeletal (n = 132, 17%) and gastrointestinal (n = 125, 16.5%). Taxane‐based regimens were associated with the most AEs (n = 286, 38%). In a cohort of patients with breast cancer treated in the ambulatory setting, 4 out of 10 patients developed at least one serious AE during the study period. Future research should identify measures to reduce the incidence and severity of such complications.
Enhances the resistance of rice to lepidopteran pests by fusing the Cry1Ca and Cry2Aa genes with self‐cleavage peptide sequence
Authors: Liu Qing , Deng Lihua , Weng Lvshui , Li Jinjiang , Li Xinyan , Kang Weiwei , Duan Yaping , Xiao Guoying 
Published: October 2024

AbstractBACKGROUNDAccumulation of two or more Bacillus thuringiensis (Bt) proteins in plant not only improves the resistance to pests and broadens the resistance spectrum of crops, but also delays the development of pest resistance.RESULTSThe self‐cleavage peptide sequence was used to link two codon‐optimized genes, so as to achieve simultaneous accumulation of two low homologous insecticidal proteins in one plant. The rice transformants accumulating Cry1Ca and Cry2Aa proteins were fed to local lepidopteran pests and the larva mortality in 5 days were 100%. The sum of Cry1Ca and Cry2Aa proteins in leaves of transformants E1C&2A‐1 and E2A&1C‐18 were 10.60 and 9.55 μg g−1 fresh weight (FW), respectively, and the larva mortality of fall armyworm fed on their leaves for 5 days reached 100%. For the control transformants that expressed one Bt protein, the content of Cry1Ca in leaves of transformant E1CM031 was 14.94 μg g−1 FW, and that of Cry2Aa in leaves of transformant B2A4008S was 11.90 μg g−1 FW, but the larva mortality of fall armyworm fed on leaves of E1CM031 and B2A4008S for 5 days were 77.78% and 52.78%, respectively. Although the total Bt contents in transformants expressing one Bt protein were higher than that of transformants expressing two Bt proteins, the lethality of transformants expressing one Bt protein were obviously lower than that of transformants expressing two Bt proteins.CONCLUSIONThe lethal effect of accumulating both Cry1Ca and Cry2Aa proteins in rice was stronger than that of amassing Cry1Ca or Cry2Aa protein only, which meant there was synergistic effect between Cry1Ca and Cry2Aa proteins. © 2024 Society of Chemical Industry.
Joint modeling of degradation signals and time‐to‐event data for the prediction of remaining useful life
Authors: Brumm Sebastian , Linstead Erik , Chen Junde , Balakrishnan Narayanaswamy , Wen Yuxin 
Published: October 2024

AbstractAccurate prediction of remaining useful life (RUL) for in‐service systems plays an important role in ensuring efficient operation of industrial equipment and in preventing unexpected equipment failures. In this paper, we present a prognostic framework for real‐time RUL prediction based on joint modeling of both degradation signals and time‐to‐event data. The proposed model employs a change point‐based general path model to capture signal non‐linearity and Neural network (NN) based Cox model to link the time‐to‐event data with the estimated degradation trend. An empirical two‐step scheme for hyperparameter estimation is proposed to enhance prognostic accuracy. Furthermore, an efficient Bayesian model updating procedure, integrated with recursive particle filtering, is used to facilitate online prediction, achieving accurate RUL prediction in real‐time and accounting for uncertainties in RUL prediction. Simulation and real‐life case studies demonstrate the advantages of the proposed method over existing approaches.
Reliability analysis for binary Lévy degradation processes using characteristic functions
Authors: Shi Yu , Feng Qianmei 
Published: October 2024

AbstractMany engineering systems experience complex degradation processes along with random shocks that often pose a risk to the safe and reliable operations of the system. The analysis of dependence among multiple degradation processes has been a challenging task in the field of reliability engineering. To study dependence behaviors and jump uncertainties among degradation processes, one of the effective approaches is to model these degradation processes using multidimensional Lévy subordinators. However, a critical obstacle arises in determining the convergent mathematical form of the reliability function under Lévy measures and distributions. To obtain a closed form of reliability function, this study investigates the Lévy measure and the characteristic function of multiple dependent degradation processes. Each degradation process is modeled by a one‐dimensional Lévy subordinator utilizing the marginal Lévy measure and characteristic function. The dependence among all dimensions is described by the Lévy copula and the associated multidimensional Lévy measure. For a two‐dimensional case, we derive the reliability function and probability density function (PDF) from the characteristic function and the inverse Fourier transform. Numerical examples are provided to demonstrate the proposed models for reliability and lifetime analysis of multidimensional degradation processes in engineering systems.
A reliability allocation method for mechanical products considering meta‐action performance factors and failure correlation
Authors: Chen Yifan 
Published: October 2024

AbstractMotion is one of the most basic forms of mechanical products, which directly determines the performance stability and function realization of products. In this paper, a reliability allocation method for mechanical products is proposed, which takes the meta‐action with motion characteristics as the allocation granularity unit, and fully considers the performance factors and failure correlation of the meta‐action. Firstly, the function‐motion‐action (FMA) decomposition method is used to establish the decomposition model of mechanical products to determine all the meta‐actions that realize the function of products. Secondly, four factors that affect the reliability of the meta‐action are introduced, namely sensitivity, severity, potential improvement, and dynamic performance, and the comprehensive allocation weight model of meta‐actions is established. Furthermore, to solve the deficiency of the traditional failure independence hypothesis, Copula theory is used to establish the reliability allocation model of the meta‐action system. Finally, a numerical control turntable is taken as an example to illustrate the applicability of the method. The results show that the reliability allocation value of the proposed method is significantly lower than that of the traditional method when the reliability index of the product is guaranteed, which provides theoretical guidance for the reliability design of mechanical products.
Online Learning‐Based Event‐Triggered Model Predictive Control With Shrinking Prediction Horizon for Perturbed Nonlinear Systems
Authors: Lin Min , Shan Shuo , Sun Zhongqi , Xia Yuanqing 
Published: October 2024

ABSTRACTThis article proposes an online learning‐based event‐triggered model predictive control (OLEMPC) scheme for constrained nonlinear systems with state‐dependent uncertainties. The scheme incorporates both the nominal and the learned models to ensure favorable theoretical properties during online learning. A composite measurement‐triggering strategy is devised to reduce the number of state measurements as well as solving the optimization problems. This strategy attenuates the conservatism in measurement and triggering through combining the event‐ and self‐triggering approaches. By implementing the algorithm, both state measurement and triggering frequency further decrease with the online refinement of the prediction model, and the prediction horizon adaptively shrinks as the state approaches the terminal region. It is shown that the feasibility of the optimization problem and stability of the closed‐loop system are guaranteed. Simulation results verify the effectiveness of this scheme in ensuring closed‐loop performance and alleviating computational burden.
The mediating role of HRM outcomes in the relationship between employee development and company performance results: A study with a sustainable HRM perspective on Central European MNCs
Authors: Stor Marzena , Haromszeki Łukasz 
Published: October 2024

AbstractThe main goal of the article is to determine the mediating role of human resources management (HRM) outcomes in the relationships between employee development (ED) and company performance results and to establish whether there are any identifiable regularities in this scope in the pre‐pandemic and pandemic period of COVID‐19, the latter being understood as a crisis period, in the headquarters (HQs) and foreign subsidiaries of multinational companies (MNCs). Additionally, the article aims to undertake an interpretation of the obtained research data from the perspective of sustainable HRM. The empirical research encompassed 200 MNCs with headquarters in Central Europe. The research encompassed 200 MNCs headquartered in Central Europe. For statistical analysis, the Partial Least Squares Structural Equation Modeling was used. The results indicate that HRM outcomes serve as a positive intermediary and this mediation is stronger in crisis times. The findings enrich both theory and practice, providing a solid framework for incorporating sustainable HRM into organizational strategic management, including ED, especially in MNCs, to boost performance and resilience. An innovative aspect is the application of employee key performance indicators as the efficiency index to study variable effects.
A Cross-Sectional Study of the Vulval Dermatology Clinic Population Over a 4-Year Period and Development of a National Vulval Disease Database
Authors: de Brito Marianne , Kirby Lisa , Lomas Kate , Javed Aysha , Owen Caroline , Simpson Rosalind 
Published: October 2024

Abstract

Background
Vulval disease significantly impacts quality of life but is historically under-researched. The epidemiology and aetiology of many vulval conditions is unclear. Data to optimise patient care are lacking.

Objectives
To describe the population attending a specialist vulval dermatology clinic and achieve consensus amongst vulval experts on data items to be collected for a future national vulval database.

Methods
This descriptive cross-sectional study analysed data that was prospectively collected during clinical contact with consecutive new patients at a vulval dermatology clinic over 4 years.
A two-stage electronic-Delphi survey was performed with British vulval experts. Consensus was defined as ≥75% agreement on items for inclusion.

Results
The database included 424 (including 29 paediatric) patients. Most patients were White British (71%), with a significant Asian population (13%). Long symptom duration (9.5% &gt; 10 years) and multiple diagnoses, up to 4, were common. Exploratory associations were identified between irritant contact dermatitis and urinary and faecal incontinence, frequent vulval washing and lichen simplex, urinary incontinence and lichen sclerosus and a negative association between candidiasis and age.
Following two rounds of the electronic-Delphi survey, consensus was achieved for 18 items that 28 participants agreed were important for a future database.

Conclusions
We report disease incidence, patient pathways, outcome measures and potential associations. Though not generalisable, this large UK-based study could inform future projects to improve patient care and support ongoing research, such as a national vulval disease database, for which we also achieve expert consensus on the most valuable items to include.
Therapeutic Potential of Aryl Sulfonamides: Synthesis, Antiproliferative, Antioxidant, Antiparasitic and Molecular Docking Studies
Authors: Tambat Nazia , Tambe Pranav , Sheikh Kounsar N. , Shaikh Amin , Saleh Khaled M. , AlSakhen Mai F. , Kanaan Sana I. , Al Nasr Ibrahim S. , Koko Waleed S. , Khan Tariq A. , Schobert Rainer , Biersack Bernhard , Tahtamouni Lubna H. , Ahmed Khursheed 
Published: October 2024

AbstractThis study outlines the synthesis of pyrazine sulfonamides (3 a–3 i) along with halo‐phenyl derivatives (4 a–4 j and 5 a–5 e). The antiproliferative effects were tested against MCF‐7 breast cancer, and colon carcinoma HT‐29, HCT‐116 WT, and HCT‐116 p53 knock‐out mutant cell lines. Compounds 3 b and 3 c were notably active against HCT‐116 WT cells, while 3 e and 3 h were moderately effective against MCF‐7 cells. Among the halo‐phenyl sulfonamides, 4e and 4j were active against MCF‐7 cells, and 5 b was active against HCT‐116 WT cells. The most promising compounds were evaluated against non‐tumorigenic cells, demonstrating cancer selectivity. Compounds 3 b, 3 c, 3 e, 3 h, and 5 b showed dose‐dependent inhibition of colony formation. Compound 3 f exhibited free radical scavenging activity comparable to ascorbic acid. Molecular docking revealed strong binding to thymidylate synthase (3 b, 5 b), Akt‐3 protein kinase (3 e, 3 h, 4 e, 4 j), and tyrosinase (3 f, 3 h). The compounds also exhibited antiparasitic activity against Toxoplasma gondii and Leishmania major, with modifications enhancing selectivity for T. gondii. Substitutions in compounds 4 b and 4 d increased activity against T. gondii while reducing toxicity. Notably, compound 4 f emerged as a T. gondii‐selective lead drug. These findings suggest sulfonamides may help treat complex diseases like cancer and infections.
Solar Selectivity of Silver Nanoparticles Modified Copper Oxide Nanocomposite Thin Films Prepared by Facile Chemical Oxidation Method
Authors: Vijay Arasu Inbasekaran , Suresh Santhanakrishnan , Kathiresan Karuppiah , Pugazhenthiran Nalandhiran , Awad Alahmadi Tahani , Rameshkumar Perumal , Karthick Kumar Senthuran , Muthuchelian Krishnaswamy 
Published: October 2024

AbstractSilver nanoparticles modified copper oxide nanocomposite thin films (Ag‐CuO NC TFs) and pristine CuO TF were successfully synthesized on copper substrates using a chemical oxidation route. X‐ray diffractometry (XRD) characterization of Ag‐CuO NC TFs revealed the formation of monoclinic crystal structured CuO. Scanning electron microscopy (SEM) images showed a star‐like grain morphology of the Ag‐CuO NC TFs. Energy dispersive X‐ray spectroscopy (EDX) analysis ascertained the presence of anticipated elements without impurities. Fourier transform infrared spectroscopy (FTIR) investigation confirmed the presence of Ag NPs on CuO in the Ag‐CuO NC TFs. Raman spectroscopy examination indicated the presence of a spinel structure with vibrational and tetrahedral sites. UV‐Vis‐NIR reflectance analysis demonstrated that Ag‐CuO NC TFs with 2.0 wt.% Ag NPs exhibited solar absorptance of 72.39 %, thermal emittance of 4.3 %, and a highest solar selectivity of 16.83 among the prepared thin films. These results suggest that the Ag‐CuO NC TFs could be promising candidates for use as solar selective absorbers in solar thermal energy conversion devices.