bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraoperative Neuromonitoring: Principles and Considerations for Perioperative Nurses
Authors: Roth Michael , Rakers Leah 
Published: June 2019

ABSTRACTIntraoperative neuromonitoring (IONM) is a method used to warn the surgeon of impending neurological damage while it can still be corrected, ideally preventing a permanent neurological deficit in the surgical patient. It was originally used in neurosurgery, but now also applies to other surgical specialties. Comprehensive monitoring of a patient's neurological status requires using a variety of approaches. The IONM tests most frequently used in the OR are somatosensory evoked potentials; transcranial electrical motor evoked potentials; electromyography, including cranial nerve monitoring; and electroencephalography. With its increased use during a variety of operative and other invasive procedures, most perioperative nurses will be exposed to IONM at some point in their careers. This article provides perioperative nurses with a basic understanding of IONM, including the framework, purpose, associated terminology, and nursing implications.
One‐step synthesis of hydrophilic graphene‐Fe3O4‐PVA composite film: Micromorphology and performance
Authors: Wang Pengjun , Zhang Mengyi , Liu Yang , Wang Liqiu , Lv Qiulan , Xu Daxing , Liu Xiu , Wang Guangtao , Yang Wan , Wang Pengchen , Yu Tengbo , Xing Shichao 
Published: June 2019

ABSTRACTMultifunctional polymers have wide applications in smart materials. In this study, the multifunctional polymer (hydrophilic graphene‐Fe3O4‐PVA, GFP composite films) were synthesized by mixing with hydrophilic graphene (HG), ferrous ammonium sulfate, and ferric chloride in PVA solution through one‐pot coprecipitation method. GFP composite films were characterized by XRD, FT‐IR. Their morphology and particle size of Fe3O4 in GFP composite film were observed by TEM, SEM, and AFM. The results indicated that the morphology of Fe3O4 in GFP could be modulated from sphere shape to rod structure by the loading quantity of HG. Besides, many properties of GFP composite films were investigated. Firstly, GFP composite films demonstrated the fast magnetic response and high thermal stability. Secondly, the introduction of HG not only simultaneously enhanced the stiffness and ductility of GFP composite films, but also improved their flame retarding performance. Finally, HG regulating effect for the morphology of Fe3O4 in GFP and improvement mechanism of HG for mechanical performance of GFP composite films were illustrated. Both of them might be contributed to the hydrogen bonds effect among Fe3O4, PVA, and HG. Thus, these multifunctional GFP composite films can be applicable as the basis of fabricating smart materials in different fields. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48174.
Set stabilization of boolean networks via sampled‐data control
Authors: Sun Liangjie , Lu Jianquan , Lou Jungang , Li Lulu 
Published: June 2019

AbstractThe paper investigates the sampled‐data state feedback control (SDSFC) for set stabilization of Boolean control networks (BCNs). Set stabilization means that a system converges to a subset of the state space under certain controllers. Assume that the given subset is
, where
and sampling period is τ. We consider two conditions q  ≤  τ;q  >  τ and for any given subset
, calculate the corresponding largest control invariant subset (LCIS). Moreover, a design procedure to calculate all possible SDSFCs for set stabilization of BCNs is obtained. Ultimately, we provide an example to demonstrate the efficiency of the results.
Enhanced electrochemiluminescence from reduced graphene oxide–CdTe quantum dots for highly selective determination of copper ion
Authors: Hu Fang Xin , Wang Juanli , Chen Shihong , Rao Qianghai 
Published: June 2019

AbstractAn electrochemiluminescence (ECL) sensor based on reduced graphene oxide–CdTe quantum dots (RGO–CdTe QDs) composites for detecting copper ion (Cu2+) was proposed. The ECL behaviours of the RGO–CdTe QD modified electrode were investigated with H2O2 as the co‐reactant. Quantitative detection of Cu2+ was realized as Cu2+ could effectively quench the ECL signal of the RGO–CdTe QDs. A wide linear range of 1.00 × 10−14 to 1.00 × 10−4 M (R = 0.9953) was obtained under optimized conditions, and a detection limit (S/N = 3) was achieved of as low as 3.33 × 10−15 M. The proposed sensor also exhibited good stability and selectivity for the detection of copper ions. Finally, the analytical application of the proposed sensor was also evaluated using river water.
UPLC–Q‐TOF/MS characterization of efficacy substances on osteoblasts differentiation and function in rat serum after administration of Wang‐Bi tablet
Authors: Wang Huijun , Guan Yunyun , Wu Ruoming , Lv Xing , Shen Xiaoyan , Ye Guan 
Published: June 2019

AbstractWang‐Bi tablet (WB) is popularly used for the treatment of rheumatoid arthritis. However, few studies have been carried out on its active ingredients and mechanism. In this study, the effect of WB medicated serum on the changes in differentiation and function in osteoblast was investigated, the results showed that WB induced the production of ALP and mineralized nodules to promote the final maturation of osteoblasts and enhance the function of osteoblasts. The potential mechanism may that WB significantly inhibits gene expressions of RANKL and miR‐141, up‐regulates the gene expressions of RUNX2 and OPG, decreases expression of DKK‐1 and increases levels of β‐catenin protein to promote the activation of Wnt/β‐catenin signaling pathways, which enhances osteogenesis and bone repair function. To investigate which compounds contributed to the activity and mechanisms, a total of 138 compounds were characterized from WB, and 13 parent molecules and eight metabolites in rat serum were rapidly characterized by UPLC–Q‐TOF/MS. Total glycosides of paeony, loganin, α‐linolenic acid, linoleic acid and naringin from WB may contribute to the actions on osteoblasts according to our study and literature review. Our research provides a method to explore the bioactive ingredients and action mechanisms of WB.
Business strategy for sustainable development: Impact of life cycle inventory and life cycle impact assessment steps in supply chain design and planning
Authors: Elias Mota Bruna Alexandra , Cerqueira de Sousa Gouveia Carvalho Ana Isabel , Azevedo Rodrigues Gomes Maria Isabel , Ferreira Dias Barbosa‐Povoa Ana Paula 
Published: June 2019

AbstractSustainability reporting has become a central instrument in displaying a company's strategy and engagement with a more sustainable society. Life cycle assessment (LCA) is an important tool in this context as it is aimed to analyze the entire life cycle of the product/service, instead of focusing on one focal firm. However, the lack of standardized guidelines in its application raises questions regarding the usefulness and validity of results. This study contributes to the improvement of sustainability reporting through the identification of the uncertainty sources in life cycle methodologies that have the biggest impact in the definition of business and environmental strategies, exploring a supply chain‐oriented analysis. The focus is on life cycle inventory (LCI) and life cycle impact assessment (LCIA). A multiobjective optimization‐based methodology is applied to a supply chain case study in the pulp and paper industry. Environmental and economic objectives are considered. Results show that different LCIA methods and different normalization data sets result in significantly different business and environmental strategies. However, different system models and cultural perspectives at the LCI step and variations in the characterization factors tend to lead to the same decisions. Important insights are gained regarding the impact of nonstandardized analysis of the application of LCA in supply chain design and planning decisions and consequently on business strategy definition and sustainability reporting. Furthermore, the importance of operations research methods to improve LCA‐based studies and of bridging the gap between LCA and supply chain management bodies of knowledge is highlighted in this work.
Telomere length in cervical exfoliated cells, interaction with HPV genotype, and cervical cancer occurrence among high‐risk HPV‐positive women
Authors: Chen Xiaojun , Wei Sun , Ma Hongxia , Jin Guangfu , Hu Zhibin , Suping Han , Li Dake , Hang Dong , Wu Xiaohua , Li Ni 
Published: June 2019

AbstractBackgroundAlthough high‐risk human papillomavirus (HR‐HPV) infection is recognized as the main cause of cervical cancer, only a minority of HPV‐infected women develop this malignancy. Increasing evidence suggests that alterations of telomere length might be implicated in carcinogenesis. However, the association between cervical cancer and telomere length remains unknown.MethodsThis case‐control study included 591 cervical cancer patients and 373 cancer‐free controls, all of whom were infected with HR‐HPV. Relative telomere length (RTL) in cervical cancer exfoliated cells was measured by quantitative PCR. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression analysis.ResultsHPV16, 18, 52, and 58 were common in both case and control groups. The proportion of HPV16 infection tended to increase across the quartiles of RTL (Ptrend < 0.001). There was no statistically significant association of RTL with tumor differentiation, histological type, and FIGO stage. After adjustment for age and HPV types, the lowest quartile of RTL presented a 49% lower risk (OR = 0.51, 95% CI: 0.35, 0.76; P < 0.001) than those with the highest quartile of RTL. There was also a dose‐response relationship of shorter RTL on lower risk of cervical cancer (Ptrend < 0.001).ConclusionShortened telomere length in cervical exfoliated cells was related to the lower risk of cervical cancer among HR‐HPV‐positive women, which might help to improve cervical cancer screening and surveillance. Further prospective studies with large sample should be designed to validate our preliminary findings, and evaluate the potential efficacy of telomere length for cervical cancer screening.
Identity, representations, religion, and apologizing for past wrongdoings: Muslim discourse about Indonesia's 1965–66 massacres of communists
Authors: Putra Idhamsyah Eka , Wagner Wolfgang , Rufaedah Any , Holtz Peter 
Published: June 2019

AbstractSince 1965, in Indonesia, people labelled as communists and their descendants have been mistreated. Recently, there has been an issue to apologize to them, but up until now, no official apology has been offered by the Indonesian government. The present study aims to understand how communism is perceived in Indonesia and why communism attributes labelled to a person can lead to negative effects, such as social exclusions. We interviewed 23 Muslims living in Jakarta (i.e., majority group) and used a thematic analysis to organize and describe the data. We found that Muslims who see communists as non‐believers view communist members as dangerous and a threat for the unity of the Republic of Indonesia. Among participants with such beliefs, the past maltreatments to accused communists are justified and legitimate; any apology toward the victims is considered not needed. The findings are discussed in the context of collective blaming and group essentialization, and ways to solve the problems are suggested.
Multilayer feature descriptors fusion CNN models for fine‐grained visual recognition
Authors: Hou Yong , Luo Hangzai , Zhao Wanqing , Zhang Xiang , Wang Jun , Peng Jinye 
Published: June 2019

AbstractFine‐grained image classification is a challenging topic in the field of computer vision. General models based on first‐order local features cannot achieve acceptable performance because the features are not so efficient in capturing fine‐grained difference. A bilinear convolutional neural network (CNN) model exhibits that a second‐order statistical feature is more efficient in capturing fine‐grained difference than a first‐order local feature. However, this framework only considers the extraction of a second‐order feature descriptor, using a single convolutional layer. The potential effective classification features of other convolutional layers are ignored, resulting in loss of recognition accuracy. In this paper, a multilayer feature descriptors fusion CNN model is proposed. It fully considers the second‐order feature descriptors and the first‐order local feature descriptor generated by different layers. Experimental verification was carried out on fine‐grained classification benchmark data sets, CUB‐200‐2011, Stanford Cars, and FGVC‐aircraft. Compared with the bilinear CNN model, the proposed method has improved accuracy by 0.8%, 1.1%, and 5.5%. Compared with the compact bilinear pooling model, there is an accuracy increase of 0.64%, 1.63%, and 1.45%, respectively. In addition, the proposed model effectively uses multiple 1×1 convolution kernels to reduce dimension. The experimental results show that the multilayer low‐dimensional second‐order feature descriptors fusion model has comparable recognition accuracy of the original model.
Image‐based authoring of herd animations
Authors: Ecormier‐Nocca Pierre , Pettré Julien , Memari Pooran , Cani Marie‐Paule 
Published: June 2019

AbstractAnimating herds of animals while achieving both convincing global shapes and plausible distributions within the herd is difficult, using simulation methods. In this work, we allow users to rely on photos of real herds, which are widely available, for keyframing their animation. More precisely, we learn global and local distribution features in each photo of the input set (which may depict different numbers of animals) and transfer them to the group of animals to be animated, thanks to a new statistical learning method enabling to analyze distributions of ellipses, as well as their density and orientation fields. The animated herd reconstructs the desired distribution at each keyframe while avoiding obstacles. As our results show, our method offers both high‐level user control and help toward realism, enabling to easily author herd animations.
A computational approach for spider web‐inspired fabrication of string art
Authors: Je Seungwoo , Abileva Yekaterina , Bianchi Andrea , Bazin Jean‐Charles 
Published: June 2019

AbstractCreating objects with threads is commonly referred to as string art. It is typically a manual, tedious work reserved for skilled artists. In this paper, we investigate how to automatically fabricate string art pieces from one single continuous thread in such a way that it looks like an input image. The proposed system consists of a thread connection optimization algorithm and a custom‐made fabrication machine. It allows casual users to create their own personalized string art pieces in a fully automatic manner. Quantitative and qualitative evaluations demonstrated our system can create visually appealing results.
Human Fatty Acid Synthase: A Computational Study of the Transfer of the Acyl Moieties from MAT to the ACP Domain
Authors: Paiva Pedro , Sousa Sérgio F. , Fernandes Pedro A. , João Ramos Maria 
Published: June 2019

AbstractHuman Fatty Acid Synthase (hFAS) is a multidomain enzyme responsible for the biosynthesis of saturated fatty acids, which are crucial for numerous biological processes. During the biosynthetic reaction, hFAS incorporates acetyl and malonyl moieties through the action of its malonyl‐acetyl transferase (MAT) domain. These precursor molecules are transferred from CoA to the acyl‐carrier protein (ACP) domain by a two‐stage ping‐pong catalytic mechanism. The first stage, during which the acyl moieties are relocated from CoA to the MAT domain, has been elucidated in a previous work of ours. In this study, we employ QM/MM calculations at the DLPNO‐CCSD(T)/CBS:AMBER level of theory to understand the catalytic machinery behind the transfer of the acyl moieties from MAT to the ACP domain. The results show that the acyl transfer to the ACP's phosphopantetheine (PNS) occurs in two sequential events: Step 3) asynchronous concerted reaction that combines the deprotonation of the PNS's thiol group and the nucleophilic attack on the acyl‐Ser581 ester carbon; Step 4) tetrahedral intermediate breakdown and regeneration of the catalytic Ser581/His683 dyad. The energy barriers of these two steps are inferior to those reported for the first catalytic stage, suggesting that the rate‐limiting step of the MAT mechanism lies on Stage 1, particularly on the concerted nucleophilic attack that starts the reaction. The oxyanion hole, formed by the backbone amines of Met499 and Leu582, was reported to transiently stabilize the tetrahedral intermediate and to play a favorable catalytic effect on the overall MAT reaction, particularly through the reduction of the energetic span. The knowledge gathered in this work complements previous experimental and theoretical studies and instigates further investigations that explore the therapeutic potential of hFAS.
Electroorganic Synthesis and the Construction of Addressable Molecular Surfaces
Authors: Yeh Nai‐Hua , Zhu Yu , Moeller Kevin D. 
Published: June 2019

AbstractIn this Minireview, an electroorganic synthesis approach to the construction of addressable, complex molecular surfaces is described along with the parameters that guided the development of that synthetic approach. The result of the work is a synthetic toolbox that will allow microelectrode arrays to be used for the “real‐time” monitoring of small molecule interactions with biological targets.
Programmed death–ligand 1 expression on direct Pap‐stained cytology smears from non–small cell lung cancer: Comparison with cell blocks and surgical resection specimens
Authors: Lozano Maria D. , Abengozar‐Muela Marta , Echeveste José I. , Subtil José Carlos , Bertó Juan , Gúrpide Alfonso , Calvo Alfonso , de Andrea Carlos E. 
Published: June 2019

BackgroundProgrammed death–ligand 1 (PD‐L1) expression, as assessed by immunohistochemistry (IHC), is used to select patients with non–small cell lung cancer (NSCLC) for anti‐programmed cell death protein 1 (PD‐1)/PD‐L1 therapy. The current study evaluated the feasibility and efficacy of PD‐L1 immunostaining and quantitation on direct Papanicolaou‐stained cytological smears compared with formalin‐fixed paraffin‐embedded samples (cytological cell blocks and surgical resection specimens) in NSCLC cases using 2 commercially available assays: the PD‐L1 IHC 22C3 pharmDx assay (Agilent Technologies/Dako, Carpinteria, CA, USA) and the Ventana SP263 Assay (Ventana Medical Systems Inc, Tucson, Arizona).MethodsPD‐L1 immunostaining using either both or one of the assays was tested in 117 sets of paired samples obtained from 62 NSCLC cases. The tumor proportion score was reported in every case following the recommendations of the International Association for the Study of Lung Cancer (IASLC).ResultsIn 57 sets of samples, both PD‐L1 assays were used. Due to the availability of samples, only 1 assay was performed in 3 sets of samples and in 2 cases, only cytology smears were used and tested for both assays. A total of 113 sets of paired samples finally were evaluated; 4 cases could not be studied due to intense nonspecific background staining. A significant concordance between the 2 assays on cytological smears was found. Concordance between paired cytological smears and formalin‐fixed paraffin‐embedded samples was observed in 97.3% of the cases.ConclusionsThe quantification of PD‐L1 expression on direct Papanicolaou‐stained cytology smears is feasible and reliable for both PD‐L1 assays.
HPV testing through p16 immunocytochemistry in neck‐mass FNA and its correlation with tissue samples
Authors: Yang Zhongbo , Gomez‐Fernandez Carmen , Lora Gonzalez Manuel , Esebua Magda , Kerr Darcy A. 
Published: June 2019

BackgroundFine‐needle aspiration (FNA) of a neck mass is frequently the initial diagnostic procedure for patients with human papillomavirus–positive head and neck squamous cell carcinoma. By performing a p16 immunocytochemistry (ICC) stain on FNA material, the pathologist can help to direct the treating physician's search for the primary site and to select the proper management for the patient. There is currently no established threshold for the evaluation of p16 ICC in cytology samples. This study was aimed at establishing an optimal threshold for p16 ICC interpretation in cytology samples.MethodsThe pathology databases were searched for all neck‐mass FNAs diagnosed as squamous cell carcinoma from January 2010 to March 2019. p16 ICC was performed on cytology smears, and the percentage and intensity of p16‐positive cells were assessed. Receiver operating characteristic (ROC) curves were plotted to determine the best cutoff threshold for p16 positivity on cytology smears.Resultsp16 ICC was performed on 50 cytology smears. An analysis of 8 different thresholds (combinations of the percentage and intensity of the p16 stain) using ROC curves demonstrated the best threshold to be 50% p16 staining with a sensitivity of 74% and a specificity of 100%. Applying the threshold used for surgical specimens (70%) to cytology samples resulted in a low sensitivity (45%).Conclusionsp16 ICC on cytology smears shows diminished staining in comparison with surgical samples. Using 50% staining as the cutoff to consider positivity for p16 in cytology smears is proposed to decrease false‐negative results while maintaining specificity.
Enhance packet transmission using improved channel assignment in wireless mess network
Authors: Sathyasri B. , Ganesh E.N. , Senthilkumar P. 
Published: June 2019

SummaryAn efficient technique called channel Assignment (CA) is used to exploit the multiple non‐overlapping channels that improves capacity and decreases intervention in the wireless mesh network. Although it can reduce total network interference, there may be certain design issues by which network performance can be unfair. For maximizing the usage of wireless LAN network spectrum in these environments, many studies have discovered how to use the complete spectrum while transferring the data via mesh network. The proposed paper elaborates about the Enhanced Traffic‐Aware Channel Assignment Protocol. This protocol helps the mesh nodes present in the large‐scale mesh networks to assign the channels.
Development of in‐house materials for the verification of specific gravity measurements: Homogeneity, stability, and proficiency studies
Authors: Velasco‐Bejarano Benjamín , Mercado Karina , Camacho Evangelina , Rodríguez Leonardo , Gómez‐Pliego Raquel , Méndez Eradio A. 
Published: June 2019

AbstractWe developed and evaluated the properties of in‐house urine reference materials for the verification of laboratory refractometers, which are frequently used in clinical chemistry and doping testing laboratories. Urine was gathered from 26 healthy volunteers (16 male 30 ± 5 years old and 10 female 29 ± 4 years old), from which two urine batches were obtained: one with a low specific gravity (1.012± 0.003) and the other with a high specific gravity (1.027 ± 0.003). Homogeneity studies were conducted over 20 consecutive days. For short‐term stability studies, aliquots of both urine batches were stored at −20 ± 2°C; 3 ± 2°C; 20 ± 2°C; 45 ± 2°C for 0, 2, 7, 14 and 35 days, under both light and dark conditions. Similarly, another study was conducted to measure the long‐term stability of urine at −20 ± 2°C, over a 24‐month evaluation period. Our data showed that the urine was homogeneous and stable at −20 ± 2°C, 3 ± 2°C, 20 ± 2°C, and 45 ± 2°C under both light and dark conditions. In all cases, the urine was evaluated by specific gravity and no statistically significant differences (p ≤ 0.05) were recorded. Additionally, a proficiency test was conducted in collaboration with 15 ISO/IEC 17025 accredited laboratories, and z‐scores and performance factors were evaluated. These data indicate that this material could be used for the verification of refractometers.