bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Prospective Approach to Inform and Treat 1340 Patients at Risk for BIA-ALCL
Authors: Roberts John M. , Carr Logan W. , Jones Allison , Schilling Amber , Mackay Donald R. , Potochny John D. 
Published: April 2019

Background:
The increasing incidence and associated mortality of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) has become alarming. However, many patients remain unaware of their risk for BIA-ALCL and may overlook early warning signs of the cancer. The authors aim to contact all breast implant patients at a single institution to educate them on the disease and provide screening and treatment as indicated.

Methods:
All patients who had breast implants placed at Penn State Hershey Medical Center from 1979 to November of 2017 were mailed a letter to describe BIA-ALCL and to encourage a follow-up visit. Patient information regarding demographics, implant type, the number of calls and follow-up visits, physical examination findings, and patient decisions after being informed of the disease were recorded prospectively.

Results:
One thousand two hundred eighty-four letters were mailed to 1020 patients (79.4 percent) with smooth implants and 264 patients (20.6 percent) with textured implants. Seventy-six calls were received and 100 patients (84 smooth and 16 textured) were evaluated within the first 2 months. Of the 16 patients with textured implants, nine are undergoing secondary surgery to remove or replace their textured device.

Conclusions:
Informing patients at risk for BIA-ALCL is an important endeavor. Patients educated on the disease will likely be diagnosed and treated earlier, which can prevent the need for adjuvant chemotherapy and/or radiation therapy and decrease mortality. The authors provide a method, supporting documents, and preliminary data to help other institutions contact their breast implant patients at risk for BIA-ALCL.
Complications Following Orthognathic Surgery for Patients With Cleft Lip/Palate
Authors: Hwang Dae Seok , Choi Hong Seok , Kim Uk Kyu , Song Jae-Min 
Published: April 2019

Introduction:
Cleft lip/palate is a facial anomaly caused by an abnormal developmental process. It is also the most common congenital anomaly. Orthognathic surgery is required in 25% of patients with cleft lip and palate for the correction of dentofacial deformity. There are various complications that can occur after orthognathic surgery. Complications that can occur during surgery include bleeding, improper fracture, and injuries to the inferior alveolar nerve (IAN) and lingual nerve. Meanwhile, postoperative complications include hemorrhage, edema, pain, infection, and delayed union or nonunion. This study retrospectively examines the complications that occurred after the orthognathic surgery in cleft lip/palate patients at Pusan National University Dental Hospital.

Patients and methods:
From June 1, 2008 to July 31, 2017, we selected 17 patients who underwent orthognathic surgery for cleft lip/palate at the Department of Oral and Maxillofacial Surgery, Pusan National University Dental Hospital. The patients were treated at different hospitals for all operations related to cleft lip/palate.

Result:
Intraoperative complications include hemorrhage, inadequate fracture, injury to the IAN and lingual nerve, root damage, and fistula. The patients who were evaluated included 2 patients with inadequate fracture, 3 patients with injury to the IAN, and 1 patient with fistula. Postoperative complications (e.g., as damage of the inferior alveolar nerve and velopharyngeal insufficiency) may occur, and all patients recovered during the follow-up period of 6 months or more after the surgery. The relapse rates were A–N per 14.0%, Pog–N per 15.1%, SNA 24.4%, and SNB 4.6%. There was no statistically significant difference in relapse rate.

Conclusion:
Complications that may occur after the orthognathic surgery in the patients with cleft lip/palate are similar to those without cleft lip/palate.
Cranial Trepanation: An Ancient Neurosurgical Therapy? Thoughts of a Follower of Positivist Medicine and Anthropology
Authors: Iorio Silvia , Licata Marta , Ciliberti Rosagemma , Gazzaniga Valentina 
Published: April 2019

Abstract
The authors’ aim is to define a framework around the history of studies and analyses on cranial trepanation. In addition, based on the analytical approach of Abele de Blasio, the authors would like to reach an understanding of the various different interpretations of the origin and aetiology of the art of cranial trepanation, starting in the prehistoric era. In this brief study, historical discussions are intertwined with ethnoiatric and anthropometric techniques of the author, leading the reader into a fascinating discussion on the practice of trepanation in ancient populations.
Non-Financial Determinants and economic fluctuations – evidence from Yemen
Authors: Mohammed Sulaiman Abdullah Saif Alnasser 
Published: April 2019

Purpose
This paper aims to examine, by way of an analytical research review, the reasons for the fluctuations in the economic growth of the country of Yemen during the period from 2000 to 2014. The authors are trying to generate the answers to the following questions: Has tourism, oil price, politically instability improved? What is the impact of tourism, oil price and politically instability on economic growth before and after turbulence time? We have found that very low number of papers have written about the topic. Yemen, as a developing country, has been under the influence of an turbulence time. The term “turbulence time” refers to the series of independent uprisings that occurred in 2010 across the Arab world. There is a lack of understanding concerning the economic growth status in the existing literature during this period.

Design/methodology/approach
The authors use vector error-correction model to examine the impact of candidate variables .This review and analysis could provide an additional understanding in terms of the factors contributing to economic growth in Yemen; particularly before and after the turbulence time.

Findings
Despite oil prices having appreciated and the unemployment rate having improved, particularly after the Arab Spring, political instability has dominated the scope of determinants for economic growth in Yemen. To address the objective of this study.

Originality/value
This paper provides an additional reference about the economic status of Yemen.
Embedding hospital-based medication review
Authors: Reichenpfader Ursula , Wickström Anette , Abrandt Dahlgren Madeleine , Carlfjord Siw 
Published: April 2019

PurposeThe purpose of this paper is to explore the embedding of hospital-based medication review attending to the conflictual and developmental nature of practice. Specifically, this paper examines manifestations of contradictions and how they play out in professional practices and local embedding processes.Design/methodology/approachUsing ethnographic methods, this paper employs the activity-theoretic notion of contradictions for analyzing the embedding of medication review. Data from participant observation (in total 290 h over 48 different workdays) and 31 semi-structured interviews with different healthcare professionals in two Swedish hospital-based settings (emergency department, department of surgery) are utilized.FindingsThe conflictual and developmental potential related to three interrelated characteristics (contested, fragmented and distributed) of the activity object is shown. The contested nature is illustrated showing different conceptualizations, interests and positions both within and across different professional groups. The fragmented character of medication review is shown by tensions related to the appraisal of the utility of the newly introduced practice. Finally, the distributed character is exemplified through tensions between individual and collective responsibility when engaging in multi-site work. Overall, the need for ongoing “repair” work is demonstrated.Originality/valueBy using a practice-theoretical approach and ethnographic methods, this paper presents a novel perspective for studying local embedding processes. Following the day-to-day work of frontline clinicians captures the ongoing processes of embedding medication review and highlights the opportunities to learn from contradictions inherent in routine work practices.
Is the type and location of grocery stores a predictor of healthy and unhealthy food availability? A cross‐sectional study
Authors: Kemp Caitlin , Collins Jorja , Palermo Claire 
Published: April 2019

AimTo investigate whether geographical location or type of store is associated with differences in healthy and unhealthy food availability in grocery stores.MethodsA cross‐sectional study using the Victorian Healthy Food Basket to measure food availability (44 ‘healthy’ and 10 ‘unhealthy’ items) in a convenience sample of 112 stores in urban and regional Victoria, Australia. Logistic regression analyses assessed whether location (regional, urban), distance from capital city central business district (km) and type of store (chain supermarket, independent supermarket and general store) predicted the number of missing healthy and unhealthy food items.ResultsThere were 54 chain supermarkets, 43 independent supermarkets and 15 general stores, with 56% of stores located in urban areas and 44% located regionally. The strongest significant predictor of missing items was being a general store, which had greater odds (odds ratio (OR) = 136, 95% confidence interval (CI) = 13–1399) of having missing ‘healthy’ items and missing ‘unhealthy’ items (OR = 63, 95% CI = 7–575), compared with chain supermarkets. Independent supermarkets had increased odds of having missing ‘healthy’ items (OR = 7, 95% CI = 2–22) compared with chain supermarkets. Regional store location was a significant predictor of missing ‘healthy’ and ‘unhealthy’ items, compared with urban location (OR = 6, 95% CI = 2–25) and (OR = 7, 95% CI = 2–29), respectively.ConclusionsStore type was a stronger predictor of stores having missing ‘healthy’ and ‘unhealthy’ food items than the store distance from a large urban centre. General stores and independent supermarkets may be important settings for interventions to improve availability of healthy food.
Refugee resettlement, social media and the social organization of difference
Authors: MARLOWE JAY 
Published: April 2019

AbstractSocial media platforms allow refugees separated by distance to share information, provide support and exchange resources across borders. This connection has the potential to transform resettlement experiences as people maintain significant and ongoing relationships with transnational networks. Yet, since refugee resettlement programmes generally only scale up to the national imagination, integration remains a normative framework in most policy spheres. This article presents a 12‐month digital ethnography of 15 refugees settled in New Zealand with a view to examining their transnational practices of social media and its influence on integration and belonging. Drawing on a conceptual framework based on the social organization of difference, it contains a discussion on how online global networks increasingly inform the domains of encounters, representations and configurations. The role of social media for refugee resettlement futures and its implications for integration at times of rapid political, technological and social change concludes the article.
LncRNA KCNQ1OT1 enhanced the methotrexate resistance of colorectal cancer cells by regulating miR‐760/PPP1R1B via the cAMP signalling pathway
Authors: Xian Di , Zhao Yu 
Published: April 2019

AbstractWe aimed to explore the mechanism of the KCNQ1OT1/miR‐760/PPP1R1B axis acting to regulate methotrexate (MTX) resistance of colorectal cancer (CRC). Differentially expressed mRNAs and lncRNAs in MTX‐sensitive CRC cell lines and MTX‐resistant cell lines were determined through microarray analysis. Application of bioinformatics analysis was aimed to uncover the relationships among the lncRNAs/miRNAs/mRNAs, and to demonstrate the effects of cAMP signalling pathway in MTX‐resistant CRC. The expression level of RNA and proteins was, respectively, detected using qRT‐PCR and Western blot assays, whereas the dual‐luciferase reporter gene assay was implemented to verify the targeted relationship. The influence of the lncRNA/miRNA/mRNA axis on biological functions of MTX‐resistant cells and on the growth of tumours determined through both vitro and vivo experiments. LncRNA KCNQ1OT1 and PPP1R1B mRNA were overexpressed in MTX‐resistant CRC tumour cells. KCNQ1OT1 functioned as a sponge of miR‐760, which targeted PPP1R1B. Knockdown of KCNQ1OT1 enhanced chemosensitivity towards MTX through the sponging of miR‐760. MiR‐760 expressed at low levels targeted PPP1R1B in the activated cAMP signalling pathway under MTX treatment. Knockdown of KCNQ1OT1 dampened the proliferation of MTX‐resistant (HT29/MTX) cells by regulating the miR‐760/PPP1R1B axis, which also induced cell cycle arrest together with apoptosis. KCNQ1OT1 regulated the expression of PPP1R1B and the downstream genes CREB and CBP in the cAMP signalling pathway. MTX showed a suppressive function on CRC progression. KCNQ1OT1 enhanced the MTX resistance of CRC cells by regulating miR‐760‐mediated PPP1R1B expression via the cAMP signalling pathway.
Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation
Authors: Yun Eun-Jin , Lin Chun-Jung , Dang Andrew , Hernandez Elizabeth , Guo Jiaming , Chen Wei-Min , Allison Joyce , Kim Nathan , Kapur Payal , Brugarolas James , Wu Kaijie , He Dalin , Lai Chih-Ho , Lin Ho , Saha Debabrata , Baek Seung Tae , Chen Benjamin P.C. , Hsieh Jer-Tsong 
Published: April 2019

Abstract

Purpose:
Renal cell carcinoma (RCC) is known to be highly radioresistant but the mechanisms associated with radioresistance have remained elusive. We found DOC-2/DAB2 interactive protein (DAB2IP) frequently downregulated in RCC, is associated with radioresistance. In this study, we investigated the underlying mechanism regulating radioresistance by DAB2IP and developed appropriate treatment.

Experimental Design:
Several RCC lines with or without DAB2IP expression were irradiated with ionizing radiation (IR) for determining their radiosensitivities based on colony formation assay. To investigate the underlying regulatory mechanism of DAB2IP, immunoprecipitation-mass spectrometry was performed to identify DAB2IP-interactive proteins. PARP-1 expression and enzymatic activity were determined using qRT-PCR, Western blot analysis, and ELISA. In vivo ubiquitination assay was used to test PARP-1 degradation. Furthermore, in vivo mice xenograft model and patient-derived xenograft (PDX) model were used to determine the effect of combination therapy to sensitizing tumors to IR.

Results:
We notice that DAB2IP-deficient RCC cells acquire IR-resistance. Mechanistically, DAB2IP can form a complex with PARP-1 and E3 ligases that is responsible for degrading PARP-1. Indeed, elevated PARP-1 levels are associated with the IR resistance in RCC cells. Furthermore, PARP-1 inhibitor can enhance the IR response of either RCC xenograft model or PDX model.

Conclusions:
In this study, we unveil that loss of DAB2IP resulted in elevated PARP-1 protein is associated with IR-resistance in RCC. These results provide a new targeting strategy to improve the efficacy of radiotherapy of RCC.
Aspidistra minor (Asparagaceae, Nolinoideae), a tiny new species from Vietnam
Authors: VISLOBOKOV NIKOLAY A. , KUZNETSOV ANDREY N. , KUZNETSOVA SVETLANA P. , ROMANOV MIKHAIL S. , NURALIEV MAXIM S. 
Published: April 2019

Aspidistra minor is described and illustrated as a new species from southern Vietnam (Gia Lai province, Kon Chu Rang Nature Reserve). The new species possesses very small ovate to elliptic leaf blades and very small flowers with stamens inserted at the base of the perigone. In flower structure, the new species resembles A. leucographa and A. elatior but strongly differs in shape of leaf blades and position of stamens.
The diagnostic accuracy of headache measurement instruments: A systematic review and meta-analysis focusing on headaches associated with musculoskeletal symptoms
Authors: van der Meer Hedwig A , Visscher Corine M , Vredeveld Tom , Nijhuis van der Sanden Maria WG , HH Engelbert Raoul , Speksnijder Caroline M 
Published: April 2019

Aim To systematically review the available literature on the diagnostic accuracy of questionnaires and measurement instruments for headaches associated with musculoskeletal symptoms. Design Articles were eligible for inclusion when the diagnostic accuracy (sensitivity/specificity) was established for measurement instruments for headaches associated with musculoskeletal symptoms in an adult population. The databases searched were PubMed (1966–2018), Cochrane (1898–2018) and Cinahl (1988–2018). Methodological quality was assessed with the Quality Assessment of Diagnostic Accuracy Studies tool (QUADAS-2) and COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist for criterion validity. When possible, a meta-analysis was performed. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) recommendations were applied to establish the level of evidence per measurement instrument. Results From 3450 articles identified, 31 articles were included in this review. Eleven measurement instruments for migraine were identified, of which the ID-Migraine is recommended with a moderate level of evidence and a pooled sensitivity of 0.87 (95% CI: 0.85–0.89) and specificity of 0.75 (95% CI: 0.72–0.78). Six measurement instruments examined both migraine and tension-type headache and only the Headache Screening Questionnaire – Dutch version has a moderate level of evidence with a sensitivity of 0.69 (95% CI 0.55–0.80) and specificity of 0.90 (95% CI 0.77–0.96) for migraine, and a sensitivity of 0.36 (95% CI 0.21–0.54) and specificity of 0.86 (95% CI 0.74–0.92) for tension-type headache. For cervicogenic headache, only the cervical flexion rotation test was identified and had a very low level of evidence with a pooled sensitivity of 0.83 (95% CI 0.72–0.94) and specificity of 0.82 (95% CI 0.73–0.91). Discussion The current review is the first to establish an overview of the diagnostic accuracy of measurement instruments for headaches associated with musculoskeletal factors. However, as most measurement instruments were validated in one study, pooling was not always possible. Risk of bias was a serious problem for most studies, decreasing the level of evidence. More research is needed to enhance the level of evidence for existing measurement instruments for multiple headaches.
Recommended Cancer Screening in Accountable Care Organizations: Trends in Colonoscopy and Mammography in the Medicare Shared Savings Program
Authors: Cole Alexander P. , Krasnova Anna , Ramaswamy Ashwin , Fletcher Sean A. , Friedlander David F. , McNabb-Baltar Julia , Melnitchouk Nelya , Lipsitz Stuart R. , Sun Maxine , Kibel Adam S. , Golshan Mehra , Haider Adil H. , Weissman Joel S. , Trinh Quoc-Dien 
Published: April 2019

PURPOSE: Accountable care organizations (ACOs) are a delivery and payment model designed to encourage integrated, high-value care. We designed a study to test the association between ACOs and two recommended cancer screening tests, colonoscopy for colorectal cancer and mammography for breast cancer. METHODS: Using the random 20% sample of Medicare claims, beneficiaries were attributed to ACO or non-ACO cohorts on the basis of providers’ enrollment in the Medicare Shared Savings Program. An inverse probability of treatment weighting was used to balance patient characteristics between ACO and non-ACO cohorts. A propensity score–weighted, difference-in-differences analysis was then performed using the same provider groups in 2010—pre-ACO—as a baseline. A secondary analysis for older—nonrecommended—age ranges was performed. RESULTS: Prevalence of colonoscopy in recommended age ranges in ACOs from 2010 to 2014 increased from 15.3% (95% CI, 14.9% to 15.6%) to 17.9% (95% CI, 17.3% to 18.5%). This differed significantly from the change in non-ACOs (difference in differences, 1.2%; P < .001). Among women in ACOs, mammography prevalence rose from 53.7% (95% CI, 53.0% to 54.4%) to 54.9% (95% CI, 54.2% to 55.7%). In contrast to colonoscopy, the difference in mammography prevalence was not significantly different in ACO versus non-ACOs (difference in differences, 0.49%; P < .13). A similar pattern was also observed in older—nonrecommended—age ranges with significant difference in differences (ACO v non-ACO) in colonoscopy, but not mammography. CONCLUSION: The impact of ACOs on cancer screening varies between screening tests. Our results are consistent with a greater effect of ACOs on high-cost, high-complexity screening services, which may be more sensitive to integrated care delivery models.
Generalization of one method of a filter generator key recovery
Authors: Alekseev Evgeniy K. , Kuschinskaya Lyudmila A. 
Published: April 2019

Abstract
We describe an algorithm extending the previously proposed method of key recovery of a filter generator. The algorithm is based on an approximation of the combining function by algebraically degenerate functions. We give estimates of the computational complexity, reliability, and the amount of memory used by the method. Examples of application of the method are considered, in particular, for the analysis of the LILI-128 cipher.
Modules over strongly semiprime rings
Authors: Tuganbaev Askar A. 
Published: April 2019

Abstract
For a ring A, the following conditions are equivalent.

A is a right strongly semiprime ring.

Every right A-module which is injective with respect to some essential right ideal of the ring A, is an injective module.

Every quasi-injective right A-module which is injective with respect to some essential right ideal of the ring A is an injective module.
The role of context in sociolinguistic perception
Authors: Hilton Katherine , Jeong Sunwoo 
Published: April 2019

Abstract
Previous research demonstrates that listeners make social inferences about people based on how they speak, and that these inferences vary depending on the linguistic and social context. An open question is exactly how contextual enrichment (i.e. information about the speaker and speaking situation) comes to influence sociolinguistic perception. This paper addresses this question by analyzing data from 10 perception experiments investigating three different linguistic phenomena: number agreement in existential there constructions, intonation contours in declarative sentences, and overlapping speech in conversation. We observe an overall trend that increasing contextual enrichment obscures the effects of linguistic forms. In contextually impoverished stimuli, number nonagreement and rising declaratives trigger perceptions that speakers are less educated and more polite, respectively, but show no effect on listener perceptions when embedded in more contextually rich stimuli. By contrast, overlapping speech shows robust effects on perceived interruptiveness, even in contextually rich stimuli. Drawing on theories from social psychology and linguistic anthropology, we argue that if listeners are able to form sufficient impressions of speakers before encountering the target linguistic feature, they will not modify their impressions to incorporate the social meanings conveyed by the target linguistic feature, unless these social meanings are highly enregistered.