bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental and simulation studies on the mold replicability in the thermoforming process
Authors: Namdari Navid , Mosaddegh Peiman 
Published: February 2019

Abstract
In the precision thermoforming process, one of the main drawbacks occurs in the profile deviation of the produced part. In this study, the effect of different thermoforming process parameters on the mold replicability of a high impact polystyrene container produced by vacuum forming and drape forming processes has been experimentally and numerically investigated. According to experimental results, in the drape forming process, when the initial sheet thickness increases, the part will have higher mold replicability, whereas in the vacuum forming process, by increasing the initial sheet thickness, the mold replicability increases and reaches its peak, then decreases. The results also indicate that both temperature and vacuum pressure exhibit the most significant effect on mold replicability of the part. Furthermore, the finite element method is utilized by the implementation of a fully thermomechanically coupled hyperviscoelastic constitutive model in ABAQUS 6.13. By using this material model, it is possible to compare the sensitivity of the output (mold replicability of the part) to the changes in the range of the process parameters. The simulation results verified by the experimental data and the hyperviscoelastic model showed to be an outstanding and stable platform for the process simulation.
Entwurf deformierbarer Spiegel für den Einsatz in Hochleistungslasern
Authors: Schmidt Kevin , Piehler Stefan , Dannecker Benjamin , Dietrich Tom , Raisch Adrian , Graf Thomas , Abdou Ahmed Marwan , Sawodny Oliver 
Published: February 2019

ZusammenfassungThermische Effekte limitieren die Leistungsskalierbarkeit in Hochleistungsscheibenlasern und können durch konstruktive Maßnahmen nur bedingt reduziert werden. Ein neuartiger Ansatz zur Kompensation der thermisch induzierten Effekte wird durch den resonatorinternen Einsatz hochleistungstauglicher adaptiver Spiegel ermöglicht. In diesem Beitrag werden hierfür zwei mögliche Technologien vorgestellt und charakterisiert: Während pneumatisch aktuierte Flächenlastspiegel eine gezielte Kompensation bekannter Wellenfrontstörungen erlauben, bieten optisch adressierte deformierbare Spiegel die Möglichkeit nahezu arbiträre Deformationen zu realisieren. Jene Bauform nutzt thermoelastische Effekte infolge der lokalen Erwärmung des Spiegels um gewünschte Deformationen zu erzielen.
Theoretical Prediction on the Structural, Electronic, Mechanical, and Thermodynamic Properties of TaSi2 with a C40 Structure Under Pressure
Authors: Zhu HuaJun , Yang Tao , Zhou Yang , Hua SuDong , Yang JinWen 
Published: February 2019

Abstract
The structural parameters, electronic structures, and mechanical and thermodynamic properties of TaSi2 under different pressures have been completely explored by a combination of density functional theory and quasi-harmonic Debye model. Results show that our computed structural parameters and elastic constants are in consistency with available experimental findings and previous theoretical calculations. The electronic structures of TaSi2 under different pressures including band structures and density of states are reported. It turns out that TaSi2 should be metallic. The elastic constants Cij
, bulk modulus B, shear modulus G, Young’s modulus E, Poisson’s ratio ν, B/G, Debye temperature θ, and wave velocities under pressures are also evaluated successfully. The calculated Cij
obeys the Born–Huang stability criterion, which demonstrates that TaSi2 is mechanically stable under different pressures. More interestingly, the three-dimensional surface constructions and projections of E and B under different pressures are also systematically evaluated. With the increase of applied pressure, TaSi2 exhibits subtle anisotropy under zero pressure, and the anisotropy strengthened. Finally, the dependence of the thermodynamic properties on pressure/temperature is obtained and analyzed for the first time.
Experimental Study on Energy Consumption of Rock Cutting under Different Groove Geometry
Authors: Zhu Xiaohua , Deng Zilong , Liu Weiji 
Published: February 2019

Abstract
The Polycrystalline Diamond Compact (PDC) cutter is a kind of rock breaking tool that is widely used in oil and gas exploitation. PDC cutter directly contacts with the rock during the process of the rock cutting. Therefore, it is of great significance to investigate the rock breaking mechanism of the PDC cutter to improve the rock breaking efficiency. This article sets up a test bench of rock cutting, which consists of a single cutter, high-speed cameras, and several data collectors, to monitor the cutting force, mechanical specific energy, energy dissipation, and the chip formation process. The results show that a frequent fluctuation of the value of the tangential force is related to the fly leaping phenomenon and particle size of debris. The ratio coefficient of the cross section describes the relations of energy dissipation between different sections. While changing the distribution density of the PDC cutter on the drilling bit, a minimum value of rock-breaking specific work will appear, and the rock breaking efficiency can be improved. The arc length back virtual work and the virtual crushing work express the storage and release of rock internal energy, which can explain the fracture phenomenon from the aspect of energy dissipation.
Improvement of Methadone Maintenance Treatment (MMT) Process Through Development and Implementation of Methadone Dispenser
Authors: Mohd Amran Nor Amirah , Ab Karim Mohd Sayuti , Abd Rashid Rusdi , Tuan Zahari Tuan Zaharinie , Latif Ishak Amirul 
Published: February 2019

Abstract
Methadone is a controlled drug and can be prescribed by an authorized person in charge, under the direction of medical practitioners, for particular patients, to cure their addiction to opioid substances. The development and evaluation of a methadone dispenser present a prototype solution for solving the current manual methadone dispensing problems, which are prone to human error, with the implementation of the methadone maintenance treatment (MMT) program at the same time to increase public awareness about this program. In the current study, the performance of a methadone dispenser is evaluated by investigating the simulation analysis, feasibility, and efficiency of the device as compared to the manual technique. For testing purposes, methadone syrup was replicated with sugar solution of 66.6 g/50 mL at 25°C with a dynamic viscosity of 36.680 mPa.s. Thus, it was quantified that the time taken to dispense the sugar solution by using the methadone dispenser has shown a significant improvement of 81.40 % time reductions as compared to the manual technique. The low repeatability percentage of the methadone dispenser by 1.64 % contributes to a high precision device that is reliable enough to be implemented in the MMT program with a dispensing accuracy increment of 3.87 %, as compared to the manual technique. The findings suggest that the methadone dispenser is reliable and feasible and contributes to error reduction for implementation in the MMT program with approximately ≈ 97 % efficiency.
Influence of Loading Sequence on Low Cycle Fatigue Behavior of Normal Weight Concrete under Direct Tension
Authors: Chen Xudong , Shi Dandan , Li Shengtao , Fan Xiangqian , Lu Jun 
Published: February 2019

AbstractUnder seismic action, concrete can be considered to be subjected to multistage constant cyclic loads. Moreover, the failure of concrete is predominantly manifested in cracking caused by tension. This article studies the dynamic mechanical properties of concrete specimens under direct cyclic tension. According to the experimental results, this article discusses selections of damage parameters and the establishment of the evolution model on the basis of elastic modulus degradation and plastic strain accumulation. According to reasonable damage parameters, the damage evolution mechanism is investigated to propose a modified model, by which the failure process and the fatigue life of concrete under cyclic loading can be predicted. Additionally, the proposed damage evolution model is used to analyze the experimental data of the related literature and this study, which both turn out a good match in the prediction.
Pore Size Distribution, Compressibility, and Strain Kinetics upon Exposure to Methane of Four Bituminous Coal Specimens from Kaiping Basin, China
Authors: Zhu Jie , Zhang Bo , Zhang Yang , Jiang Yaodong 
Published: February 2019

Abstract
Gas migration through coal matrix and cleats not only includes gas sorption and desorption but also leads to coal strain development. In this article, a series of experiments were carried out to investigate the strain development in four unconfined bituminous coal samples exposed to methane at various pressures. The dominant factors for sorption/desorption-induced deformation were associated with pore characteristics. Pore size distribution for all samples was determined by mercury intrusion porosimetry, nitrogen adsorption, and carbon dioxide adsorption techniques. The results show that there were differences in the pore surface area, pore shape, and pore size distribution of coal samples. Coal swelled when methane was injected and shrank when gas was released. The coal radial strains were always larger than axial strains at adsorption and desorption phases because the samples were drilled along coal cleat. The residual strain remaining after the adsorption–desorption cycle may be positive or negative. The strains of coal samples were different even with the same injected gas pressure. The total pore volume is not a dominant factor for sorption/desorption strain and rate. The pore size distribution and pore type also should be comprehensively considered.
Spatial Data Indexing and Query Processing in GeoCloud
Authors: Shankar Karthi , Sevugan Prabu 
Published: February 2019

Abstract
GeoCloud is essential for spatial data management. This article depicts GeoCloud and SpatialHadoop, both of which are developed for spatial information, indexing, and query processing. It contains traditional spatial indexing that comprises R-tree, Hilbert R-tree, and improved Bloom filter tree. We enhance the query search by utilizing Spatial Join, Range Query, k-nearest neighbor (k-NN), and Max k-NN queries. By doing so, we implement the data structures and query evaluation performance of different spatial datasets in GeoCloud instances with SpatialHadoop. We show that our proposed system is more efficient in terms of data storage and retrieval in GeoCloud.
Priming of Adult Incision Response by Early-Life Injury: Neonatal Microglial Inhibition Has Persistent But Sexually Dimorphic Effects in Adult Rats
Authors: Moriarty Orla , Tu YuShan , Sengar Ameet S. , Salter Michael W. , Beggs Simon , Walker Suellen M. 
Published: February 2019

Neonatal hindpaw incision primes developing spinal nociceptive circuitry, resulting in enhanced hyperalgesia following reinjury in adulthood. Spinal microglia contribute to this persistent effect, and microglial inhibition at the time of adult reincision blocks the enhanced hyperalgesia. Here, we pharmacologically inhibited microglial function with systemic minocycline or intrathecal SB203580 at the time of neonatal incision and evaluated sex-dependent differences following adult reincision. Incision in adult male and female rats induced equivalent hyperalgesia and spinal dorsal horn expression of genes associated with microglial proliferation (Emr1) and transformation to a reactive phenotype (Irf8). In control adults with prior neonatal incision, the enhanced degree and duration of incision-induced hyperalgesia and spinal microglial responses to reincision were equivalent in males and females. However, microglial inhibition at the time of the neonatal incision revealed sex-dependent effects: the persistent mechanical and thermal hyperalgesia following reincision in adulthood was prevented in males but unaffected in females. Similarly, reincision inducedEmr1andIrf8gene expression was downregulated in males, but not in females, following neonatal incision with minocycline. To evaluate the distribution of reincision hyperalgesia, prior neonatal incision was performed at different body sites. Hyperalgesia was maximal when the same paw was reincised, and was increased following prior incision at ipsilateral, but not contralateral, sites, supporting a segmentally restricted spinal mechanism. These data highlight the contribution of spinal microglial mechanisms to persistent effects of early-life injury in males, and sex-dependent differences in the ability of microglial inhibition to prevent the transition to a persistent pain state span developmental stages.SIGNIFICANCE STATEMENTFollowing the same surgery, some patients develop persistent pain. Contributory mechanisms are not fully understood, but early-life experience and sex/gender may influence the transition to chronic pain. Surgery and painful procedural interventions in vulnerable preterm neonates are associated with long-term alterations in somatosensory function and pain that differ in males and females. Surgical injury in neonatal rodents primes the developing nociceptive system and enhances reinjury response in adulthood. Neuroimmune interactions are critical mediators of persistent pain, but sex-dependent differences in spinal neuroglial signaling influence the efficacy of microglial inhibitors following adult injury. Neonatal microglial inhibition has beneficial long-term effects on reinjury response in adult males only, emphasizing the importance of evaluating sex-dependent differences at all ages in preclinical studies.
Electron-Impact Mass Spectrometry of PTCDA Molecules in the Gas Phase
Authors: Zavilopulo A. , Shpenik O. 
Published: February 2019

The complete and dissociative ionizations of a 3,4,9,10-perylene-tetracarboxylic-dianhydride (C24H8O6, PTCDA) molecule in the gas phase have been studied, by using electron-impact mass spectrometry in an energy interval of 5–90 eV. The molecule is found to decay into the following fragment ions: the perylene core C20H8+ and its half C10H4+, as well as CO+, CO2+ , and O+ ions. The energy dependences of the cross-sections of the complete ionization of a PTCDA molecule and its fragment ions are analyzed. The energy of the complete ionization of a PTCDA molecule and the energies, at which its fragments appear, are determined. The temperature dependences of the formation of the most intensive fragment ions are measured, by using 80-eV electrons in a temperature interval of 320–500 K.
Cost of Disease Progression in Patients with Metastatic Breast, Lung, and Colorectal Cancer
Authors: Reyes Carolina , Engel-Nitz Nicole M. , DaCosta Byfield Stacey , Ravelo Arliene , Ogale Sarika , Bancroft Tim , Anderson Amy , Chen May , Matasar Matthew 
Published: February 2019

Abstract

Introduction
To reduce health care costs and improve care, payers and physician groups are piloting value-based and episodic or bundled-care payment models in oncology. Disease progression and associated costs may affect these models, particularly if such programs do not account for disease severity and progression risk across patient populations. This study estimated the incremental cost of disease progression in patients diagnosed with metastatic breast cancer (mBC), colorectal cancer (mCRC) and lung cancer (mLC) and compared costs among patients with and without progression.

Methods
This was a retrospective study using U.S. administrative claims data from commercial and Medicare Advantage health care enrollees with evidence of mBC, mCRC, and mLC and systemic antineoplastic agent use from July 1, 2006, to August 31, 2014. Outcome measures included disease progression, 12-month health care costs, and 3-year cumulative predictive health care costs.

Results
Of 5,709 patients with mBC, 3,707 patients with mCRC, and 5,201 patients with mLC, 56.8% of patients with mBC, 58.1% of those with mCRC, and 80.3% of those with mLC patients had evidence of disease progression over 12 months. Among patients with mBC and mCRC, adjusted and unadjusted health care costs were significantly higher among progressors versus nonprogressors. Per-patient-per-month costs, which accounted for variable follow-up time, were almost twice as high among progressors versus nonprogressors in patients with mBC, mCRC, and mLC. In each of the three cancer types, delays in progression were associated with lower health care costs.

Conclusion
Progression of mLC, mBC, and mCRC was associated with higher health care costs over a 12-month period. Delayed cancer progression was associated with substantial cost reductions in patients with each of the three cancer types.

Implications for Practice
Data on the rates and incremental health care costs of disease progression in patients with solid tumor cancers are lacking. This study estimated the incremental costs of disease progression in patients diagnosed with lung cancer, breast cancer, and colorectal cancer and compared health care costs in patients with and without evidence of disease progression in a real-world population. The data obtained in our study quantify the economic value of delaying or preventing disease progression and may inform payers and physician groups about value-based payment programs.
Minimally Invasive Cordotomy for Refractory Cancer Pain: A Randomized Controlled Trial
Authors: Viswanathan Ashwin , Vedantam Aditya , Hess Kenneth R. , Ochoa Jewel , Dougherty Patrick M. , Reddy Akhila S. , Koyyalagunta Dhanalakshmi , Reddy Suresh , Bruera Eduardo 
Published: February 2019

AbstractBackgroundUp to 30% of patients with cancer continue to suffer from pain despite aggressive supportive care. The present study aimed to determine whether cordotomy can improve cancer pain refractory to interdisciplinary palliative care.Materials and MethodsIn this randomized controlled trial, we recruited patients with refractory unilateral somatic pain, defined as a pain intensity (PI) ≥4, after more than three palliative care evaluations. Patients were randomized to percutaneous computed tomography-guided cordotomy or continued interdisciplinary palliative care. The primary outcome was 33% improvement in PI at 1 week after cordotomy or study enrollment as measured by the Edmonton Symptom Assessment Scale.ResultsSixteen patients were enrolled (nine female, median age 58 years). Six of seven patients (85.7%) randomized to cordotomy experienced &gt;33% reduction in PI (median preprocedure PI = 7, range 6–10; 1 week after cordotomy median PI = 1, range 0–6; p = .022). Zero of nine patients randomized to palliative care achieved a 33% reduction in PI. Seven patients (77.8%) randomized to palliative care elected to undergo cordotomy after 1 week. All of these patients experienced &gt;33% reduction in PI (median preprocedure PI = 8, range 4–10; 1 week after cordotomy median PI = 0, range 0–1; p = .022). No patients were withdrawn from the study because of adverse effects of the intervention.ConclusionThese data support the use of cordotomy for pain refractory to optimal palliative care. The findings of this study justify a large-scale randomized controlled trial of percutaneous cordotomy.
Clinical Outcomes of Patients with Advanced Cancer and Pre-Existing Autoimmune Diseases Treated with Anti-Programmed Death-1 Immunotherapy: A Real-World Transverse Study
Authors: Cortellini Alessio , Buti Sebastiano , Santini Daniele , Perrone Fabiana , Giusti Raffaele , Tiseo Marcello , Bersanelli Melissa , Michiara Maria , Grassadonia Antonino , Brocco Davide , Tinari Nicola , De Tursi Michele , Zoratto Federica , Veltri Enzo , Marconcini Riccardo , Malorgio Francesco , Garufi Carlo , Russano Marco , Anesi Cecilia , Zeppola Tea , Filetti Marco , Marchetti Paolo , Botticelli Andrea , Antonini Cappellini Gian Carlo , De Galitiis Federica , Vitale Maria Giuseppa , Sabbatini Roberto , Bracarda Sergio , Berardi Rossana , Rinaldi Silvia , Tudini Marianna , Silva Rosa Rita , Pireddu Annagrazia , Atzori Francesco , Chiari Rita , Ricciuti Biagio , Iacono Daniela , Migliorino Maria Rita , Rossi Antonio , Porzio Giampiero , Cannita Katia , Ciciarelli Valeria , Fargnoli Maria Concetta , Ascierto Paolo Antonio , Ficorella Corrado 
Published: February 2019

AbstractBackgroundPatients with a history of autoimmune diseases (AIDs) have not usually been included in clinical trials with immune checkpoint inhibitors.Materials and MethodsConsecutive patients with advanced cancer, treated with anti-programmed death-1 (PD-1) agents, were evaluated according to the presence of pre-existing AIDs. The incidence of immune-related adverse events (irAEs) and clinical outcomes were compared among subgroups.ResultsA total of 751 patients were enrolled; median age was 69 years. Primary tumors were as follows: non-small cell lung cancer, 492 (65.5%); melanoma, 159 (21.2%); kidney cancer, 94 (12.5%); and others, 6 (0.8%). Male/female ratio was 499/252. Eighty-five patients (11.3%) had pre-existing AIDs, further differentiated in clinically active (17.6%) and inactive (82.4%). Among patients with pre-existing AIDs, incidence of irAEs of any grade was significantly higher when compared with patients without AIDs (65.9% vs. 39.9%). At multivariate analysis, both inactive (p = .0005) and active pre-existing AIDs (p = .0162), female sex (p = .0004), and Eastern Cooperative Oncology Group Performance Status &lt;2 (p = .0030) were significantly related to a higher incidence of irAEs of any grade. No significant differences were observed regarding grade 3/4 irAEs and objective response rate among subgroups. Pre-existing AIDs were not significantly related with progression-free survival and overall survival.ConclusionThis study quantifies the increased risk of developing irAEs in patients with pre-existing AIDs who had to be treated with anti-PD-1 immunotherapy. Nevertheless, the incidence of grade 3/4 irAEs is not significantly higher when compared with control population. The finding of a greater incidence of irAEs among female patients ranks among the “hot topics” in gender-related differences in immuno-oncology.
Türkiye’de Zihinsel Engellilerde Sanat Eğitimi İle İlgili Lisansüstü Tezlerin İncelenmesi
Authors: ÇAĞLAYAN Nuray 
Published: February 2019

Türk
eğitim sisteminde; okulöncesi eğitimden yükseköğretime kadar çeşitli basamaklar
yer almaktadır. Örgün eğitimi oluşturan bu basamaklarda özel gereksinimleri
olan bireyler için hazırlanmış eğitim programları bulunmaktadır. İşitme
engelli, görme engelli, zihinsel engelli bireyler ve üstün zekalı bireyler sahip
oldukları nitelikler gereği özel eğitime ihtiyaç duymaktadırlar. Bu çalışmanın
amacı; zihinsel engellilerde sanat eğitimi ile ilgili lisansüstü tezlerin
incelenmesidir. Çalışmanın gerçekleştirilmesinde nitel araştırma yöntemlerinden
doküman incelemesi tekniği kullanılmıştır. Bu bağlamda; çalışma amaçlarına uyan
16 lisansüstü tez incelenmiş ve çalışma sorularına göre analiz edilmiştir.
Çalışma sonucunda; zihinsel engellilerde sanat eğitimi ile ilgili lisansüstü
tezlerin 2001-2018 yılları arasında yapıldığı, 11 yüksek lisans ve 5 doktora
tezinin bulunduğu belirlenmiştir. Toplam 11 üniversitede yapılan tezlerin en
yüksek oranla (5 tez) Gazi Üniversitesinde olduğu görülmüştür. Sanat eğitimi
bağlamında ele alınan konuların belli başlıklar altında gruplandığı ve benzer
konuların tezlerde yer aldığı sonucuna ulaşılmıştır. Bu sonuçlara bağlı olarak
gerek doktora gerekse yüksek lisans düzeyinde bilimsel araştırmaların
artırılması ve tezlerde konu çeşitliliğinin sağlanması önerilmiştir