bluuebunny/crossref_metadata_2025_split huggingface dataset:
CLERK is a novel receptor kinase required for sensing of root-active CLE peptides in Arabidopsis
Authors: Anne Pauline , Amiguet-Vercher Amelia , Brandt Benjamin , Kalmbach Lothar , Geldner Niko , Hothorn Michael , Hardtke Christian S. 
Published: May 2018

ABSTRACT
CLAVATA3/EMBRYO SURROUNDING REGION (CLE) peptides are secreted endogenous plant ligands that are sensed by receptor kinases (RKs) to convey environmental and developmental inputs. Typically, this involves an RK with narrow ligand specificity that signals together with a more promiscuous co-receptor. For most CLEs, biologically relevant (co-)receptors are unknown. The dimer of the receptor-like protein CLAVATA 2 (CLV2) and the pseudokinase CORYNE (CRN) conditions perception of so-called root-active CLE peptides, the exogenous application of which suppresses root growth by preventing protophloem formation in the meristem. clv2 as well as crn null mutants are resistant to root-active CLE peptides, possibly because CLV2-CRN promotes expression of their cognate receptors. Here, we have identified the CLE-RESISTANT RECEPTOR KINASE (CLERK) gene, which is required for full sensing of root-active CLE peptides in early developing protophloem. CLERK protein can be replaced by its close homologs, SENESCENCE-ASSOCIATED RECEPTOR-LIKE KINASE (SARK) and NSP-INTERACTING KINASE 1 (NIK1). Yet neither CLERK nor NIK1 ectodomains interact biochemically with described CLE receptor ectodomains. Consistently, CLERK also acts genetically independently of CLV2-CRN. We, thus, have discovered a novel hub for redundant CLE sensing in the root.
Isometric versus Dynamic Measurements of Fatigue: Does Age Matter? A Meta-analysis
Authors: KRÜGER RENATA L. , ABOODARDA SAIED JALAL , SAMOZINO PIERRE , RICE CHARLES L. , MILLET GUILLAUME Y. 
Published: May 2018

ABSTRACT

Purpose
The assessment of power changes after fatiguing exercise provides important additional information about neuromuscular function compared with traditional isometric measurements, especially when exploring age-related changes in fatigability. Therefore, the aim of this review was to explore the effects of age on neuromuscular fatigue (NMF) when measured in isometric compared with dynamic contractions. The importance of central and peripheral mechanisms contributing to age-related NMF was discussed.

Methods
Medline, EMBASE, Cochrane Central Register of Controlled Trials, and SPORT Discus databases were searched. The combination of terms related to the intervention (fatiguing exercise), population (old people) and outcomes (isometric force and power) were used. This meta-analysis was registered on PROSPERO (CRD42016048389).

Results
Thirty-one studies were included. The meta-analyses revealed that force decrease was greater (there was more NMF) in young subjects than their older counterparts when fatigue was induced by isometric tasks (effect size [ES], 0.913; confidence interval [CI], 0.435–1.391; P < 0.001), but not when the fatiguing exercise was performed in dynamic mode (ES, 0.322; CI, −0.039 to 0.682; P = 0.08). Older individuals demonstrated a greater reduction in power after fatigue induced by either dynamic or isometric tasks (ES, −0.891; CI, −1.657 to −0.125; P = 0.023).

Conclusions
There is no difference in the isometric force loss between young and old people when fatigue is induced by dynamic tasks. However, maximal power is more decreased after fatigue tasks in older adults. Thus, the assessment of fatigue (isometric force vs power) must be considered in identifying age-related NMF mechanisms.
Hypothermia Decreases O2 Cost for Ex Vivo Contraction in Mouse Skeletal Muscle
Authors: FERRARA PATRICK J. , VERKERKE ANTHONY R. P. , BRAULT JEFFREY J. , FUNAI KATSUHIKO 
Published: May 2018

ABSTRACT

Introduction
Evidence suggests that the energy efficiency of key ATPases involved in skeletal muscle contractile activity is improved in a hypothermic condition. However, it is unclear how a decrease in temperature affects skeletal muscle O2 consumption (mVO2) induced by muscle contraction.

Methods
Isolated mouse extensor digitorum longus (EDL) muscles were incubated in a temperature-controlled (37°C or 25°C) bath that included an O2 probe. EDL muscles from one limb were subjected to the measurement of resting mVO2, and the contralateral EDL muscles were used for the measurement of mVO2 with electrically stimulated contraction. For the resting protocol, muscles were suspended at resting tension for 15 min with continuous O2 recordings. For the contraction protocol, EDL muscles underwent 10 electrically stimulated isometric contractions with continuous O2 recordings for 15 min. The rate of O2 disappearance was quantified as micromoles of O2 per minute and normalized to the wet weight of the muscle.

Results
Resting mVO2 was greater at 37°C than at 25°C, consistent with the idea that lower temperature reduces basal metabolic rate. Electrically stimulated contraction robustly increased mVO2 at both 37°C and 25°C, which was sustained for ~3 min postcontraction. During that period, mVO2 was elevated approximately fivefold at both 37°C and 25°C. Greater contraction-induced mVO2 at 37°C compared with 25°C occurred despite lower force generated at 37°C than at 25°C.

Conclusions
Together, O2 cost for muscle contraction (force–time integral per O2 consumed) was greater at 37°C than at 25°C. Levels of high-energy phosphates were consistent with greater energy demand at 37°C compared with 25°C. In conclusion, these results indicate that muscle contraction that occurs at subnormal temperature requires less O2 than at 37°C.
Maternal Physical Activity and Sex Impact Markers of Hepatic Mitochondrial Health
Authors: CUNNINGHAM RORY P. , MOORE MARY P. , MEERS GRACE M. , RUEGSEGGER GREGORY N. , BOOTH FRANK W. , RECTOR R. SCOTT 
Published: May 2018

ABSTRACT

Introduction
Maternal exercise and physical activity during the gestational period can be protective against maternal high-fat diet–induced hepatic steatosis in older offspring. However, it is unknown whether these protective effects are seen in younger offspring. In this study, we investigated whether maternal physical activity would attenuate maternal western diet (WD)–induced steatosis in young adult rats.

Methods
Female Wistar rats (7–8 wk of age) were randomized into WD (42% fat, 27% sucrose) or normal chow diet (ND), and further randomized into physical activity (RUN) or sedentary (SED) conditions for a total of four groups. Dams returned to ND/SED conditions after parturition. Postweaning, offspring were maintained in ND/SED conditions for 18 wk.

Results
Maternal WD-induced increases in male offspring body mass was attenuated in the WD/RUN offspring (P < 0.05). Maternal WD feeding significantly increased hepatic steatosis in male (but not female offspring), which was not attenuated by maternal RUN. However, maternal RUN increased (P < 0.05) hepatic markers of mitochondrial biogenesis and mitophagy (mitochondrial transcription factor A, peroxisome proliferator activator receptor γ, and nuclear factor E2–related factor 2) in all offspring and the mitophagy marker BCL2-interacting protein 3 in WD/RUN offspring. Interestingly, hepatic markers of de novo lipogenesis (fatty acid synthase and acetyl coenzyme A carboxylase), mitophagy (autophagy-related gene 12:5, BCL2-interacting protein 3, P62, and LC3 II/I), and mitochondria biogenesis/content (mitochondrial transcription factor A and OXPHOS-Complex II) were significantly increased in female versus male offspring.

Conclusion
Although maternal physical activity did not attenuate maternal WD-induced hepatic steatosis as has been previously reported in older adult offspring, it did significantly increase hepatic markers of mitochondrial biogenesis and mitophagy. Furthermore, female offspring had elevated hepatic markers of mitochondrial health, possibly explaining why female rats are protected against maternal WD-induced hepatic steatosis. Future studies are warranted to shed light on the time line of hepatic steatosis development under the influence of maternal physical activity.
SeqAcademy: an educational pipeline for RNA-Seq and ChIP-Seq analysis
Authors: Ather Syed Hussain , Awe Olaitan Igbagbo , Butler Thomas J. , Denka Tamiru , Semick Stephen Andrew , Tang Wanhu , Busby Ben 
Published: May 2018

Quantification of gene expression and characterization of gene transcript structures are central problems in molecular biology. RNA sequencing (RNA-Seq) and chromatin immunoprecipitation sequencing (ChIP-Seq) are important methods, but can be cumbersome and difficult for beginners to learn. To teach interested students and scientists how to analyze RNA-Seq and ChIP-Seq data, we present a start-to-finish tutorial for analyzing RNA-Seq and ChIP-Seq data: SeqAcademy (source code: https://github.com/NCBI-Hackathons/seqacademy, webpage: http://www.seqacademy.org/). This user-friendly pipeline, fully written in Jupyter Notebook, emphasizes the use of publicly available RNA-Seq and ChIP-Seq data and strings together popular tools that bridge that gap between raw sequencing reads and biological insight. We demonstrate practical and conceptual considerations for various RNA-Seq and ChIP-Seq analysis steps with a biological use case - a previously published yeast experiment. This work complements existing sophisticated RNA-Seq and ChIP-Seq pipelines designed for advanced users by gently introducing the critical components of RNA-Seq and ChIP-Seq analysis to the novice bioinformatician. In conclusion, this well-documented pipeline will introduce state-of-the-art RNA-Seq and ChIP-Seq analysis tools to beginning bioinformaticians and help facilitate the analysis of the burgeoning amounts of public RNA-Seq and ChIP-Seq data.
Book Reviews
Authors: Shen Wenjing 
Published: May 2018

In Book Reviews, we review an extensive and diverse range of books. They cover theory and applications in operations research, statistics, management science, econometrics, mathematics, computers, and information systems. In addition, we include books in other fields that emphasize technical applications. The editor will be pleased to receive an email from those willing to review a book, with an indication of specific areas of interest. If you are aware of a specific book that you would like to review, or that you think should be reviewed, please contact the editor. The following books are reviewed in this issue of Interfaces 48(3), May–June: Computer Age Statistical Inference, Bradley Efron and Trevor Hastie; Straight Talk on Trade: Ideas for a Sane World Economy, Dani Rodrik; Reliability and Availability Engineering: Modeling, Analysis and Applications, Kishor S. Trivedi and Andrea Bobbio.
OptimalM-Switch Surveillance Policies for Liver Cancer in a Hepatitis C–Infected Population
Authors: Chen Qiushi , Ayer Turgay , Chhatwal Jagpreet 
Published: May 2018

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the fastest-growing cause of cancer-related deaths in the United States. Most HCC cases are attributed to chronic hepatitis C virus infection, which affects nearly 3 million Americans and 100 million people globally. Although surveillance for HCC in hepatitis C patients can improve survival, the optimal surveillance policies remain unknown. In this study, we develop a mixed-integer programming (MIP)-based framework to systematically analyze a rich set of policies and determine the optimal HCC surveillance policies that maximize societal net benefit. Our MIP-based framework addresses two problem features that make dynamic programming-based formulation computationally intractable. In particular, our proposed framework allows the formulation of (1) M-switch policies that are practical for implementation and (2) tailored surveillance policies with screening intervals stratified by the precursor disease states. We theoretically analyze the HCC surveillance problem, characterize when the surveillance policies should be adapted to populations with different disease progression rates, and quantify the trade-off between decreasing HCC incidence and increasing treatment outcomes. We parameterize our model using clinical trial data, a previously validated simulation model, and published clinical studies. Our numerical analyses lead to three main results with important policy implications. First, we find that, in addition to cirrhotic patients, expanding surveillance to patients in the earlier stages of hepatitis C infection improves the cost-effectiveness of HCC surveillance. Second, compared with the “one size fits all” routine policies, we find that it is cost-effective to stratify surveillance strategies based on the stage of hepatitis C infection with less frequent cancer surveillance in the earlier stages of infection. Finally, we find that a little flexibility in the policy structure as captured by M-switch policies is sufficient to capture almost as much benefit as from complex fully dynamic policies.The e-companion is available at https://doi.org/10.1287/opre.2017.1706 .
Operating Policies in Robotic Compact Storage and Retrieval Systems
Authors: Zou Bipan , Koster René De , Xu Xianhao 
Published: May 2018

Robotic compact storage and retrieval systems (RCSRS) have seen many implementations over the last few years. In such a system, the inventory items are stored in bins, organized in a grid. In each cell of the grid, a certain number of bins are stored on top of each other. Robots with transport and lifting capabilities move on the grid roof to transport bins between manual workstations and storage stacks. We estimate performance and evaluate storage policies of RCSRS, considering both dedicated and shared storage policies coupled with random and zoned storage stacks. Semi-open queuing networks (SOQNs) are built to estimate the system performance, which can handle both immediate and delayed reshuffling processes. We approximate the models by reduced SOQNs with two load-dependent service nodes and use the matrix-geometric method to solve them. Both simulations and a real case are used to validate the analytical models. Assuming a given number of stored products, our models can be used to optimize not only the length-to-width ratio of the system but also the stack height, depending on the storage strategy used. For a given inventory and optimal system configuration, we demonstrate that the dedicated storage policy outperforms the shared storage policy when the objective is to minimize dual command throughput time. However, from a cost perspective, with a maximum dual command throughput time as a constraint, we show that shared storage substantially outperforms dedicated storage. The annualized costs of dedicated storage are up to twice as large as those of shared storage, as a result of the larger number of storage positions required by dedicated storage and the relatively lower filling degree of storage stacks. The online appendix is available at https://doi.org/10.1287/trsc.2017.0786 .
Religion, Sport, and the Return of the Prodigal Son: The Postsecular Rhetoric of LeBron James’s 2014 “I’m Coming Home” Open Letter
Authors: Bostdorff Denise M. , O’Rourke Daniel J. 
Published: May 2018

Abstract
In 2010, LeBron James, “The Chosen One,” humiliated Northeast Ohio by announcing on nationwide television that he was leaving the Cavaliers to play for Miami. James announced his return to Cleveland four years later through an open letter that set off euphoria in the region. This essay offers a postsecular framework to explain: (1) how James’s messianic image established a context in which his departure, in tandem with the way he announced his decision, made James a “sinner” in the eyes of Cleveland fans, and (2) how his open letter adapted the parable of the Prodigal Son to depict him as the son of Northeast Ohio who had made mistakes, rather than sinned and, simultaneously, as the wise father who was forgiving of others. James portrayed his departure as a necessary step in gaining maturity, yet—much like the Prodigal Son—admitted to a revelation about his relationship with Northeast Ohio.
Place of flip book animation technique in communication design education
Authors: Cemelelioğlu Altın Nur , Bingöl Hami Onur 
Published: May 2018

Due to the interdisciplinary nature of design education, it has a very broad spectrum ranging from motion picture to informative design methods. Animation techniques are also one of the important parts of this wide variety of work. Today, almost every institution is involved in animation techniques in design education. Animation with various application methods is the field where the most creative examples of motion pictures are revealed. The purpose of this research is to discuss the place of flip book animation in design education and to investigate its contributions to design education, which is one of the creative animation techniques.It is considerably significant that students experience how the form of motion pictures is created through one of the methods at a beginning level and understand the nature of motion picture in design education process. Flip book animation, is a method by which students will be able to grasp the logic of creating motion pictures using static drawing or photography. Flip book animation is one of the first animation techniques to be achieved by combining successive still images processed with different surfaces. It may be considered as an old and outdated motion pictures technique for that reason, yet there are still flip book festivals and it is used as an effective method in teaching animation process.
An unusual cause of neonatal shock: a case report
Authors: Kalagiri Ram R. , Vora Niraj , Govande Vinayak , Shetty Ashita , Raju Venkata N. , Beeram Madhava R. 
Published: May 2018

Abstract
The authors present a premature male neonate who developed subcapsular hematoma of the liver (SHL) secondary to birth trauma during the delivery process. During cesarean section, it was discovered that the infant had suffered birth trauma to the abdomen that caused intra-abdominal hemorrhage, resulting in hypovolemic shock. It was diagnosed as SHL upon abdominal ultrasound. This premature newborn infant presented with hypotension and metabolic acidosis secondary to internal hemorrhage. He was managed with volume replacement including packed red blood cells (pRBC), fresh frozen plasma and cryoprecipitate transfusions. The infant’s clinical condition improved gradually, and he went home without any problems at 36 weeks of corrected gestational age. On follow-up visits, he was found to be growing and developing appropriately. High index of suspicion, appropriate work-up and prompt treatment of shock were the key steps in the management of this infant.
Prediction of User Future Request Utilizing the Combination of Both ANN and FCM in Web Page Recommendation
Authors: Raju V. , Srinivasan N. 
Published: May 2018

Abstract
This paper explains about the web page recommendation system. This procedure encompasses consumers’ upcoming demand and web page recommendations. In the proposed web page recommendation system, potential and non-potential data can be categorized by use of the Levenberg–Marquardt firefly neural network algorithm, and forecast can be made by using the K-means clustering algorithm. Consequently, the projected representation demonstrates the infrequent contact format with the help of the representation that integrates the comparable consumer access model data that belong to the further consumer. Thereafter, the impending user data are specified to the clustering progression. The third phase of the projected process is collecting potential data with the aid of the improved fuzzy C-means clustering algorithm. The last step of our projected process is envisaging the upcoming demand for the subsequent consumer. The presentation of the projected procedure will be compared to the obtainable procedure.
Crystal structure of (E)-1-(4-(((E)-2-hydroxy-5-methylbenzylidene)amino)phenyl)ethan-1-oneO-methyl oxime, C17H18N2O2
Authors: Li Peng-Peng , Ma Jin-Xia , Li Qing-Lin , Zhao Ji-Xing , Zhao Li 
Published: May 2018

AbstractC17H18N2O2, monoclinic,P21/c(no. 14),a= 33.536(6) Å,b= 7.0566(10) Å,c= 6.1491(10) Å,β= 91.048(5)°,Z= 4,V= 1455.0(4) Å3,Rgt(F) = 0.0672,wRref(F2) = 0.1823,T= 296(2) K.
Crystal structure of poly[tetraaqua-(μ4-oxalato-κ4
O,O′:O′′,O′′′)-(μ8-benzene-1,2,4,5-tetracarboxylato-κ8
O
1:O
2:O
3:O
4:O
5:O
6:O
7:O
8)yttrium(III)], C6H5O8Y
Authors: Wen Zhi-Hui , Zhao Xiao-Xi , Zhao Dan 
Published: May 2018

Abstract
C6H5O8Y, triclinic, P1̄ (no. 2), a = 6.2090(17) Å, b = 8.573(4) Å, c = 8.863(2) Å, α = 111.018(6)°, β = 109.850(4)°, γ = 91.866(6)°, V = 407.8(2) Å3, Z = 2, R
gt(F) = 0.0435, wR
ref(F
2) = 0.1332, T = 296(2) K.
Crystal structure of methyl (R)-4-(o-chlorobenzoyl)-1-thia-4-azaspiro[4.5]decane-3-carboxylate, C17H20ClNO3S
Authors: Zhao Li-Xia , Wang Qing-Rui , Zou Yue-Li , Wu Hao , Ye Fei 
Published: May 2018

Abstract
C17H20ClNO3S, orthorhombic, P212121 (no. 19), a = 6.1984(2) Å, b = 14.3940(5) Å, c = 18.9651(6) Å, V = 1692.06(10) Å3, Z = 4, R
gt(F) = 0.0263, wR
ref(F
2) = 0.0683, T = 293(2) K.
Synthesis, structural characterization, and properties of Ag(I) complexes with N-donor ligands
Authors: Zhu Xiao-Hong , Cheng Xiao-Chun , Li Deng-Hao , Qian Yun-Hua 
Published: May 2018

Abstract
New silver complex [Ag(pz)(CF3SO3)] (1) was formed by the coordination reaction of AgCF3SO3 with pyrazine (pz) in the presence of 2-[(S)-4-isopropyl-2-oxazolyl] quinoline (L). When AgBF4 was used instead of AgCF3SO3 as the starting material, complex 2 [Ag(L)(CH3CN)](BF4) was obtained. Complexes 1 and 2 are characterized by single-crystal X-ray diffraction, IR spectroscopy and elemental, and thermogravimetric analysis. Complex 1 shows a 3D framework structure with uni-nodal eight-connected (424.64) topology while complex 2 displays a discrete mononuclear structure. The nonlinear optical properties of 2 were investigated.
Roman Ingarden’s “The Logical Attempt at a New Formulation of Philosophy: A Critical Remark”
Authors: Linsky Bernard 
Published: May 2018

Translated by Bernard Linsky
This is the first English translation of Roman Ingarden’s paper presented at the 8th World Congress of Philosophy held in Prague in 1934: “Der Logistische Versuch einer Neugestaltung der Philosophie: Eine Kritische Bemerkung”, translated here as “The Logical Attempt at a New Formulation of Philosophy: A Critical Remark”. Also translated here are brief discussions by Rudolf Carnap and Otto Neurath. These essays were published in the original German in the Proceedings of the Congress in 1936. This statement of Ingarden’s criticisms of the doctrines of the Vienna Circle has been mentioned in print, but his views have not been discussed, or indeed accurately reported to date.