bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photon‐Induced Ultrafast Multitemporal Programming of Terahertz Metadevices
Authors: Zhang Jing , Lou Jing , Wang Zhuochao , Liang Jiangang , Zhao Xilai , Huang Yindong , Chang Chao , Hu Guangwei 
Published: November 2024

AbstractDynamic terahertz (THz) metasurface can feature modulated and multiplexed electromagnetic functionalities, important for wave‐based computation, six‐generation communications, and other applications. The versatile dynamic switching typically relies on a series of complex or incompatible multifield activations, with excessive system complexity, additional loss, slow modulation speed, and inertial time‐varying properties, limiting more widespread applications. Here, a photon‐induced ultrafast programmable THz metadevice is reoprted in time‐frequency dimensions with polarization‐decoupled temporal responses. By the pixelated design with multi‐materials and triggering switches, the multimodal modulation transcends the constraints inherent in materials, enabling the ultrafast programmable temporal evolution. All the resonances can be independently programmed at the working band from 0.6 to 2 THz. The tri‐temporal (with switching time of 1.25, 1, and 4.75 ps) and bi‐temporal (with switching time of 2.25 and 4.75 ps) dynamic manipulations are performed by all‐optical driven molecularization process of hybrid metasurfaces loaded with silicon (Si) and germanium (Ge) under different polarizations. Combining these features, the temporally programmed THz logic gates are last experimentally demonstrated, possessing basic operation of XNOR, NOR, and OR, as a proof‐of‐concept application. This reported light‐driven programmable THz flat‐optics allows ultrafast hybrid molecularization processes and new possibilities for miniaturized, flexible, multifunctional, and temporally programmable integrated devices.
Naturally Inspired Tree‐Ring Structured Dressing Provides Sustained Wound Tightening and Accelerates Closure
Authors: Chen Honggui , Zhang Rui , Zhang Guo , Liang Xiaoyang , Xu Chen , Li Yang , Xu Fu‐Jian 
Published: November 2024

AbstractMechanically regulated wound dressings require a rational combination of contraction and adhesion functions as well as balancing exudate‐induced swelling issues. However, many of the reported dressings face the dilemma of impaired function and impeded wound self‐contraction due to fluid‐absorbing swelling. In this study, inspired by the tree ring, a core–ring structured hydrogel dressing capable of mechanical modulation is designed, and prepare it using a simple two‐step photopolymerization process. The core covers the center of the wound, contracts spontaneously at body temperature to generate a contractile force of 3.4 kPa, and resists swelling. Meanwhile, the ring adheres to the normal epidermis around the wound and transfers the contraction stress to the wound edge. The integration of a functionally independent core and ring ultimately achieves effective wound traction and avoids dressing swelling. In murine and porcine skin wound‐healing models, this hydrogel with a closely connected core and ring promotes healing by accelerating epidermal closure (50% closure in mouse skin on day 2, 85% closure in pig skin on day 8), collagen deposition, vascular maturation, and extracellular matrix remodeling. These results can guide further research on mechanical force modulation in wound healing, with the potential for clinical translation.
Electric‐Field Control of the Local Thermal Conductivity in Charge Transfer Oxides
Authors: Varela‐Domínguez Noa , Claro Marcel S. , Vázquez‐Vázquez Carlos , López‐Quintela Manuel Arturo , Rivadulla Francisco 
Published: November 2024

AbstractPhonons, the collective excitations responsible for heat transport in crystalline insulating solids, lack electric charge or magnetic moment, which complicates their active control via external fields. This presents a significant challenge in designing thermal equivalents of basic electronic circuit elements, such as transistors or diodes. Achieving these goals requires precise and reversible modification of thermal conductivity in materials. In this work, the continuous tuning of local thermal conductivity in charge‐transfer SrFeO3‐x and La0.6Sr0.4CoO3‐x oxides using a voltage‐biased Atomic Force Microscopy (AFM) tip at room temperature is demonstrated. This method allows the creation of micron‐sized domains with well‐defined thermal conductivity, achieving reductions of up to 50%, measured by spatially resolved Frequency Domain Thermoreflectance (FDTR). By optimizing the oxide's chemical composition, the thermal states remain stable under normal atmospheric conditions but can be reverted to their original values through thermal annealing in air. A comparison between Mott–Hubbard and charge‐transfer oxides reveals the critical role of redox‐active lattice oxygen in ensuring full reversibility of the process. This approach marks a significant step toward fabricating oxide‐based tunable microthermal resistances and other elements for thermal circuits.
Opto‐Electrical Decoupled Phototransistor for Starlight Detection
Authors: Zhou Shaoyuan , Zhang Xinyue , Wang Ying , Lin Dongyi , Zou Shoubin , Wang Jingwen , Xiao Luna , Zhang Dijie , Jiang Jianhua , Zhang Panpan , Zhang Jianbing , Tang Jiang , Zhang Zhiyong 
Published: November 2024

AbstractHighly sensitive shortwave infrared (SWIR) detectors are essential for detecting weak radiation (typically below 10−8 W·Sr−1·cm−2·µm−1) with high‐end passive image sensors. However, mainstream SWIR detection based on epitaxial photodiodes cannot effectively detect ultraweak infrared radiation due to the lack of inherent gain. Here, we develop a heterojunction‐gated field‐effect transistor (HGFET) consisting of a colloidal quantum dot (CQD)‐based p‐i‐n heterojunction and a carbon nanotube (CNT) field‐effect transistor, which achieves a high inherent gain based on an opto‐electric decoupling mechanism for suppressing noise. The stacked heterojunction absorbs infrared radiation and separates electron–hole pairs. Then, the generated photovoltage tunes the drain current of the CNT FET through an Y2O3 gate insulator. As a result, the HGFET significantly detects and amplifies SWIR signals with a high inherent gain while minimally amplifying noise, leading to a recorded specific detectivity above 1014 Jones at 1300 nm and a recorded maximum gain‐bandwidth product of 69.2 THz. Direct comparative testing indicates that the HGFET can detect weak infrared radiation at 0.46 nW cm−2 levels; thus, compared to commercial and reported SWIR detectors, this detector is much more sensitive and enables starlight detection or vision. As the fabrication process is very compatible with CMOS readout integrated circuits, the HGFET is a promising SWIR detector for realizing passive night vision imaging sensors with high resolutions that are high‐end, highly sensitive, and inexpensive.
Assembly of Silicate–Phenolic Network Coatings with Tunable Properties for Controlled Release of Small Molecules
Authors: Mazaheri Omid , Lin Zhixing , Xu Wanjun , Mohankumar Mirudula , Wang Tianzheng , Zavabeti Ali , McQuillan Rebecca V. , Chen Jingqu , Richardson Joseph J. , Mumford Kathryn A. , Caruso Frank 
Published: November 2024

AbstractEngineered coatings are pivotal for tailoring the surface properties and release profiles of materials for applications across diverse areas. However, developing robust coatings that can both encapsulate and controllably release cargo is challenging. Herein, a dynamic covalent coordination assembly strategy is used to engineer robust silicate‐based coatings, termed silicate–phenolic networks (SPNs), using sodium metasilicate and phenolic ligands (tannic acid, gallic acid, pyrogallol). The coatings are pH‐responsive (owing to the dynamic covalent bonding), and their hydrophobicity can be tuned upon their post‐functionalization with hydrophobic gallates (propyl, octyl, lauryl gallates). The potential of the SPN coatings for the controlled release of small molecules, such as urea (a widely used fertilizer), is demonstrated—controlled release of urea in soil is achieved in response to different pHs (up to 7 days) and different hydrophobicity (up to 14 days). Furthermore, leveraging the presence of silicon (within the coating) and post‐functionalization of the SPN coatings with metal ions (Fe3+, Cu2+, Zn2+) generates a multipurpose delivery system for the sustained release of micronutrient fertilizers, and silicon and metal ions, over 28 and 14 days, respectively. These SPN coatings have potential applications beyond agriculture, including nutrient delivery, separations, food packaging, and medical device fabrication.
Spatiotemporal Molecular Architecture of Lineage Allocation and Cellular Organization in Tooth Morphogenesis
Authors: Jiang Shengjie , Zhang Yuning , Zheng Huimin , Zhao Kai , Yang Yue , Lai Binbin , Deng Xuliang , Wei Yan 
Published: November 2024

AbstractThe remarkable evolution of teeth morphological complexity represents a giant leap for vertebrate. Despite its importance in life history, the understanding of spatiotemporal organization of teeth remains rudimentary. Herein, a high‐resolution genome‐wide molecular patterning of lineage allocation and cellular organization in tooth morphogenesis is described, constructed by integrating spatial transcriptome and single‐cell RNA sequencing. Twelve spatial compartments and seventeen heterogeneous cell clusters linked to tooth morphogenic milestones are identified. Eighty‐eight percent of total lineage species has already appeared in the initial tooth bud rather than the generally considered sequential emergence. A previously unrecognized sprouting‐like patterning mode of the dental papilla is discovered, that the inner compartment can break through the outer shell compartment to build up the final papilla cusp. Meanwhile, the continuum differentiation hierarchies of enamel knots in time and space are revealed. Furthermore, the regulatory network directing tooth morphogenesis is established, whereby a series of mechanotransduction signals are spatiotemporally involved beyond the well‐established classical odontogenesis signals. Finally, genes underlying tooth dysplasia are successfully tracked to highly specific time points and cell types. The results raise the idea that tooth morphogenesis is orchestrated by mechanical niches combined with biochemical signaling.
Cellulose‐Based Transparent Edible Antibacterial Oxygen‐Barrier Coating for Long‐Term Fruit Preservation
Authors: Cui Yuqian , Cheng Yixiu , Xu Zhan , Li Bingchun , Tian Weiguo , Zhang Jun 
Published: November 2024

AbstractLong‐term preservation of fresh fruit and vegetables without a cold chain is a great challenge to food security because fruits and vegetables are highly vulnerable to poor storage conditions. Fruit spoilage is a complex biochemical process that involves many factors, including microbial reproduction, oxidation, metabolism, and H2O evaporation. Only the synergy of the multiple spoilage inhibition methods can achieve long‐term freshness preservation. Herein, a multifunctional cellulose‐based preservation coating with antibacterial, oxygen/water vapor barrier, and antioxidant properties is proposed, which is based on cellulose microgel (CMG) and prepared using multi‐component composites with montmorillonite (MMT), cationic cellulose derivative (Cell‐P+), and L‐ascorbic acid (Vc). It has good wetting properties on fruits with different surfaces. This method can successfully preserve the long‐term freshness of various fruits. This highly transparent, edible, and washable multifunctional cellulose‐based fruit preservation coating can improve the quality of agricultural products, extend the shelf life of food, and reduce the cost of cold‐chain transportation.
The ADNI Administrative Core: Ensuring ADNI's success and informing future AD clinical trials
Authors: Nosheny Rachel L. , Miller Melanie , Conti Catherine , Flenniken Derek , Ashford Miriam , Diaz Adam , Fockler Juliet , Truran Diana , Kwang Winnie , Kanoria Shaveta , Veitch Dallas , Green Robert C. , Weiner Michael W. ,   Alzheimer's Disease Neuroimaging Initiative
Published: November 2024

AbstractThe Alzheimer's Disease Neuroimaging Initiative (ADNI) Administrative Core oversees and coordinates all ADNI activities, to ensure the success and maximize the impact of ADNI in advancing Alzheimer's disease (AD) research and clinical trials. It manages finances and develops policies for data sharing, publications using ADNI data, and access to ADNI biospecimens. The Core develops and executes pilot projects to guide future ADNI activities and identifies key innovative methods for inclusion in ADNI. For ADNI4, the Administrative Core collaborates with the Engagement, Clinical, and Biomarker Cores to develop and evaluate novel, digital methods and infrastructure for participant recruitment, screening, and assessment of participants. The goal of these efforts is to enroll 500 participants, including > 50% from underrepresented populations, 40% with mild cognitive impairment, and 80% with elevated AD biomarkers. This new approach also provides a unique opportunity to validate novel methods.Highlights
The Alzheimer's Disease Neuroimaging Initiative (ADNI) Administrative Core oversees and coordinates all ADNI activities.
The overall goal is to ensure ADNI's success and help design future Alzheimer's disease (AD) clinical trials.
A key innovation is data sharing without embargo to maximize scientific impact.
For ADNI4, novel, digital methods for recruitment and assessment were developed.
New methods are designed to improve the participation of underrepresented populations.
Imaging, biomarkers, and vascular cognitive impairment in China: Rationale and design for the VICA study
Authors: Cui Mei , Jin Zishuo , Wang Yingzhe , Jiang Jiwei , Peng Sisi , Wei Qiang , Zhang Shuting , Tuo Qingzhang , Xie Junchao , Leng Haixia , Wang Hongxing , Zhao Yanxin , Lei Peng , Xu Jun , Wang Kai , Zhang Junjian , Jiang Yanfeng , Ding Ding , Xie Fang , Yu Jintai , Dong Qiang ,   VICA Investigators
Published: November 2024

AbstractINTRODUCTIONVascular cognitive impairment (VCI) is highly heterogeneous, with unclear pathogenesis. Individuals with vascular risk factors (VRF), cerebral small vessel disease (CSVD), and stroke are all at risk of developing VCI. To address the growing challenges posed by VCI, the “Vascular, Imaging and Cognition Association of China” (VICA) was established.METHODSVICA aims to recruit 10,000 participants, including 2000 with VRF, 3000 with CSVD, and 5000 stroke patients, to form a nationwide multicenter cohort. The study integrates clinical, neuroimaging, and multi‐omics data to better understand VCI heterogeneity, improve disease prediction, and ensure timely diagnosis.RESULTSVICA has screened 2045 eligible VRF participants from six communities in Wuhan, Shanghai, and Taizhou, along with 602 CSVD and 1269 stroke patients from 135 hospitals nationwide. Baseline enrollment and follow‐up work are still ongoing.DISCUSSIONEstablishing a high‐quality longitudinal cohort is crucial for understanding VCI pathogenesis and developing novel markers for early screening and diagnosis.Highlights
Establish a large‐scale prospective longitudinal cohort comprising 10,000 participants, focusing on the high‐risk population of vascular cognitive impairment (VCI) in China.
Establish a nationwide three‐tier medical network, make full use of resources, and achieve extensive enrollment of patients with cerebral small vessel disease and stroke patients.
Utilize multimodal imaging and biomarkers to lay the foundation for constructing more‐precise risk models.
Introduce eye movement and gait analysis as new methods for assessing cognitive function.
Use positron emission tomography to further investigate the interaction between vascular factors and neurodegeneration.
Cerebrovascular markers of WMH and infarcts in ADNI: A historical perspective and future directions
Authors: Maillard Pauline , Fletcher Evan , Carmichael Owen , Schwarz Christopher , Seiler Stephan , DeCarli Charles ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: November 2024

AbstractWhite matter hyperintensities (WMH) and infarcts found on magnetic resonance imaging (MR infarcts) are common biomarkers of cerebrovascular disease. In this review, we summarize the methods, publications, and conclusions stemming from the Alzheimer's Disease Neuroimaging Initiative (ADNI) related to these measures. We combine analysis of WMH and MR infarct data from across the three main ADNI cohorts with a review of existing literature discussing new methodologies and scientific findings derived from these data. Although ADNI inclusion criteria were designed to minimize vascular risk factors and disease, data across all the ADNI cohorts found consistent trends of increasing WMH volumes associated with advancing age, female sex, and cognitive impairment. ADNI, initially proposed as a study to investigate biomarkers of AD pathology, has also helped elucidate the impact of asymptomatic cerebrovascular brain injury on cognition within a cohort relatively free of vascular disease. Future ADNI work will emphasize additional vascular biomarkers.Highlights
White matter hyperintensities (WMHs) are common to advancing age and likely reflect brain vascular injury among older individuals.
WMH and to a lesser extent, magnetic resonance (MR) infarcts, affect risk for transition to cognitive impairment.
WMHs and MR infarcts are present, even among Alzheimer's Disease Neuroimaging Initiative (ADNI) participants highly selected to have Alzheimer's disease (AD) as the primary pathology.
WMH burden in ADNI is greater among individuals with cognitive impairment and has been associated with AD neurodegenerative markers and cerebral amyloidosis.
The negative additive effects of cerebrovascular disease appear present, even in select populations, and future biomarker work needs to further explore this relationship.
Large‐scale deep proteomic analysis in Alzheimer's disease brain regions across race and ethnicity
Authors: Seifar Fatemeh , Fox Edward J. , Shantaraman Anantharaman , Liu Yue , Dammer Eric B. , Modeste Erica , Duong Duc M. , Yin Luming , Trautwig Adam N. , Guo Qi , Xu Kaiming , Ping Lingyan , Reddy Joseph S. , Allen Mariet , Quicksall Zachary , Heath Laura , Scanlan Jo , Wang Erming , Wang Minghui , Linden Abby Vander , Poehlman William , Chen Xianfeng , Baheti Saurabh , Ho Charlotte , Nguyen Thuy , Yepez Geovanna , Mitchell Adriana O. , Oatman Stephanie R. , Wang Xue , Carrasquillo Minerva M. , Runnels Alexi , Beach Thomas , Serrano Geidy E. , Dickson Dennis W. , Lee Edward B. , Golde Todd E. , Prokop Stefan , Barnes Lisa L. , Zhang Bin , Haroutunian Varham , Gearing Marla , Lah James. J , De Jager Philip , Bennett David A , Greenwood Anna , Ertekin‐Taner Nilüfer , Levey Allan I. , Wingo Aliza , Wingo Thomas , Seyfried Nicholas T. 
Published: November 2024

AbstractINTRODUCTIONAlzheimer's disease (AD) is the most prevalent neurodegenerative disease, yet our comprehension predominantly relies on studies within non‐Hispanic White (NHW) populations. Here we provide an extensive survey of the proteomic landscape of AD across diverse racial/ethnic groups.METHODSTwo cortical regions, from multiple centers, were harmonized by uniform neuropathological diagnosis. Among 998 unique donors, 273 donors self‐identified as African American, 229 as Latino American, and 434 as NHW.RESULTSWhile amyloid precursor protein and the microtubule‐associated protein tau demonstrated higher abundance in AD brains, no significant race‐related differences were observed. Further proteome‐wide and focused analyses (specific amyloid beta [Aβ] species and the tau domains) supported the absence of racial differences in these AD pathologies within the brain proteome.DISCUSSIONOur findings indicate that the racial differences in AD risk and clinical presentation are not underpinned by dramatically divergent patterns in the brain proteome, suggesting that other determinants account for these clinical disparities.Highlights
We present a large‐scale proteome (∼10,000 proteins) of DLPFC (998) and STG (244) across AD cases.
About 50% of samples were from racially and ethnically diverse brain donors.
Key AD proteins (amyloid and tau) correlated with CERAD and Braak stages.
No significant race‐related differences in amyloid and tau protein levels were observed in AD brains.
AD‐associated protein changes showed a strong correlation between the brain proteomes of African American and White individuals.
This dataset advances understanding of ethnoracial‐specific AD pathways and potential therapies.
Cationic Metal‐Organic Layer Delivers siRNAs to Overcome Radioresistance and Potentiate Cancer Radiotherapy
Authors: Ma Xin , Jiang Xiaomin , Wang Zitong , Fan Yingjie , Li Jinhong , Chow Cathleen , Wang Chaoyu , Deng Chenghua , Lin Wenbin 
Published: November 2024

AbstractRadiotherapy plays an important role in modern oncology, but its treatment efficacy is limited by the radioresistance of tumor cells. As a member of the inhibitor of apoptosis protein family, survivin plays a key role in developing radioresistance by mediating apoptosis evasion, promoting epithelial‐mesenchymal transition, and modulating cell cycle dynamics. Efficient downregulation of survivin expression presents a promising strategy to enhance the antitumor effects of radiotherapy. Herein, we report the design of a hafnium‐porphyrin‐based cationic metal‐organic layer (CMOL) with quaternary ammonium capping groups to deliver small interfering RNAs (siRNAs) for enhanced radiotherapy. The CMOL@siRNA nanoplatform not only increased energy deposition from X‐rays and reactive oxygen species generation via a unique radiotherapy‐radiodynamic therapy process, but also effectively delivered siRNAs to downregulate survivin expression and ameliorate radioresistance of cancer cells. Consequently, CMOL@siRNA in combination with low‐dose X‐ray irradiation demonstrated remarkable antitumor efficacy with 96.9 % and 91.4 % tumor growth inhibition in murine colorectal carcinoma and triple‐negative breast cancer models, respectively.
Modified Si3N4 filler enhancing the energy storage performance and thermal stability of a P(VDF‐HFP) based composite
Authors: Yang Zi , Xia Weimin , Zhang Shiyu , Zhang Xiaofang , Zhang Xinyi 
Published: November 2024

AbstractTo improve the high‐temperature stability of poly(vinylidene fluoride hexafluoropropylene) P(VDF‐HFP)‐based composite film for its potential application in energy storage, the modified silicon nitride (mSi3N4) nanoparticles are fabricated using silane coupling agent (KH‐570) and introduced into P(VDF‐HFP). When the mass fraction of mSi3N4 is 7.5 wt%, the recoverable energy density (Wrec) of the mSi3N4/ P(VDF‐HFP) composite film reaches to 1.79 J/cm3 under a 125 MV/m electric field, which is 82.7% higher than pure P(VDF‐HFP). Interestingly, the dielectric properties of mSi3N4/P(VDF‐HFP) show a considerable thermal stability at a high‐frequency ranging from −20 to 160°C, providing an effective approach for preparing energy storage composites working for high‐temperature environments.