bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrent oral ulceration: Etiology, classification, management, and diagnostic algorithm
Authors: Bilodeau Elizabeth A. , Lalla Rajesh V. 
Published: May 2019

AbstractRecurrent oral ulcerations are manifestations of a heterogeneous set of both general and more‐or‐less specific oral diseases due to numerous potential etiologies, including, but not limited to, infections, medications, autoimmune disease, and other systemic disease. This review discusses the pathogenesis, clinical presentation, diagnosis, and management of the common causes of recurrent oral ulceration. The following types/etiologies of recurrent oral ulceration are covered: traumatic ulceration, chemical ulceration, recurrent aphthous stomatitis, medication‐related ulceration, infectious ulceration, mucocutaneous disease, and autoimmune/systemic disease. A diagnostic algorithm for recurrent oral ulceration is also presented.
Economic and health burden of brucellosis in Kazakhstan
Authors: Charypkhan Duriya , Sultanov Akhmetzhan A. , Ivanov Nikolay. P. , Baramova Sholpan A. , Taitubayev Mereke. K. , Torgerson Paul R. 
Published: May 2019

AbstractBrucellosis is a widespread zoonotic disease considered as an emerging and re‐emerging disease with a resulting threat of public health and animal health. Official reports document an animal incidence in Kazakhstan of about 0.6% per year, and the country still registers high number of human cases annually . The main objective of this paper was to evaluate the distribution and economic impact of brucellosis in Kazakhstan. We analysed human disease incidence data obtained from the Government Sanitary & Epidemiological Service with the aim to estimate the burden of disease in terms of disability‐adjusted life years (DALYs). We also estimated the economic impact in terms of monetary losses. Additionally, we mapped the geographical distribution of the disease throughout Kazakhstan. In total, 1,334 human cases of brucellosis were registered in 2015 in Kazakhstan that resulted in 713 DALYs. Around $21 million was spent on compensation for animals that had to be slaughtered due to brucellosis, and an additional $24 million was spent on testing animals. Animal brucellosis and human brucellosis occur throughout the whole country, some trends of which are reviewed in this paper. We estimated the burden of the disease and explored possible explanation for high human incidence rates. This paper is the first to estimate the human burden of disease and the economic costs in Kazakhstan. Both of these are substantial.
SOUL‐MAKING, THEOSIS, AND EVOLUTIONARY HISTORY: AN IRENAEAN APPROACH
Authors: Collin James Henry 
Published: May 2019

AbstractIn Romans 5, St. Paul claims that death came into the world through Adam's sin. Many have taken this to foist on us a fundamentalist reading of Genesis. If death is the result of human sin, then, apparently, there cannot have been death in the world prior to human sin. This, however, is inconsistent with contemporary evolutionary biology, which requires that death predates the existence of modern humans. Although the relationship between Romans 5, Genesis, and contemporary science has been much discussed—often with goal of dissipating the idea that the two are in conflict—the specific issue of death entering the world through sin has remained difficult to resolve. I argue that the Eastern Orthodox tradition has the resources to respect both Romans 5 and contemporary science. Appealing to a broadly Irenaean notion of soul‐making, and to the idea of theosis, opens up space for an understanding of these passages that is both scientifically informed and Orthodox.
Pulverized-Coal Transport Through Pipes
Authors: Patterson R. C. 
Published: May 2019

Some typical problems related to pulverized-coal transport for steam generators have been investigated in a long-term test program.
The investigation has provided information relative to the performance of a commercial-type exhauster handling air-coal mixtures, friction factors for 8 and 12-in-diam pipe handling air-coal mixtures, general information as to the flow characteristics of air-coal mixtures in various piping systems, and methods and means for control of coal drifting in horizontal pipe.
Friction factors in the range of 0.017 to 0.035 for 8 and 12-in. pipe are indicated for the usual operating range.
Free Convection, Forced Convection, and Acoustic Vibrations in a Constant Temperature Vertical Tube
Authors: Jackson T. W. , Harrison W. B. , Boteler W. C. 
Published: May 2019

Experimental studies of heat transfer to air with superposed forced and free convection were reported in a previous paper [1]. In studies reported in this paper, the same experimental system was employed, but a complication was added in the form of acoustic vibrations in the flow field. By comparison of the results with and without acoustic vibrations under conditions which were otherwise the same, an effort has been made to determine the effect of acoustic vibrations on heat transfer. The Nusselt modulus, based on the log mean temperature difference, ranged from 17.2 to 50.6; the Graetz modulus, based on the bulk or average temperature of the air, ranged from 40.2 to 1633; and the Grashof-Prandtl D/L modulus, based on properties of air at the wall temperature, ranged from 0.967 × 105 to 1.26 × 106.
The results indicated that sound pressure levels below approximately 118 decibels had little effect on the heat-transfer coefficient. Below 118 decibels free convection forces were evident. Above 118 decibels free convection forces were apparently negligible and the effect of sound appeared to be considerable.
Heat and Mass Transfer From a Rotating Disk
Authors: Kreith F. , Taylor J. H. , Chong J. P. 
Published: May 2019

The analogy between heat, mass, and momentum transfer is applied to a rotating disk. Experimentally measured mass-transfer rates from a disk rotating in an infinite environment under laminar and turbulent conditions are related to the corresponding heat-transfer process by means of an analogy method. The experimental analog is shown to eliminate difficulties associated with accurate measurements of heat-transfer coefficients.
Experimental data on the effect of an adiabatic surface placed at various distances parallel to the disk on the transfer rate from the disk are presented. Observations of some unusual flow patterns resulting from Goertler type vortexes in the transition regime and from some as yet unexplained turbulent vortex phenomena are also reported.
Factors Influencing the Performance of Grinding Wheels
Authors: Krabacher E. J. 
Published: May 2019

Optimum utilization of grinding wheels can best be achieved if the nature of their performance and wear characteristics, and the factors that affect these characteristics, are understood and applied. As reported in this paper, a comprehensive, continuing, grinding-research program has contributed to such an understanding.
A study of the nature of grinding-wheel wear indicates that the grinding-wheel wear curve is similar to those of other cutting tools. It demonstrates further that the type of grinding operation significantly affects the nature of wheel wear. A unique technique has been developed for very accurately measuring grinding-wheel wear. This measured wear may be translated into terms of “grinding ratio,” which is the generally accepted parameter for measuring wheel wear. It is the ratio of the volume of metal removed per unit volume of wheel worn away.
Extensive studies have been carried out to determine the effect of mechanical variables on grinding ratio, power required in metal removal, and on surface finish. Experimental findings indicate that grinding ratio decreases with increased metal-removal rate and increases with workpiece diameter, decreased chip load, and increased concentration of grinding fluid. Power is found to increase with both the metal-removal rate and the amount of metal removed. It increases slightly with workpiece diameter and is affected little by work-material hardness. Surface finish is found to improve with decreased metal-removal rate and decreased chip load. It also is affected little by work diameter or work-material hardness.
Fundamental research in the mechanics of wheel wear is supplying much additional information in the study of grinding-wheel wear. The measurement of grinding forces employing a cylindrical grinding dynamometer provides the opportunity for relating the wear of grinding wheels to the basic mechanics of the process through such fundamental quantities as grinding forces, specific energy, and grinding friction.
Two additional experimental techniques for the study of chip formation in grinding have also proved to be most useful research tools. A “quick-stop” apparatus is used to freeze the grinding action by accelerating a tiny workpiece almost instantaneously to grinding-wheel speed. Another technique permits the comparison of the shape of the grinding grit and that of the contour of its path through the workpiece by a unique replicating method.
Dynamic Problems Associated With Satellite Orbit Control
Authors: Augenstein B. W. 
Published: May 2019

Many future satellite applications will require provision for changing the orbital parameters of the satellite once it is in an initial orbit. Such changes of orbital parameters can range from simple “orbit trimming,” to correct initial guidance or propulsive inaccuracies, to relatively large-scale changes in the orbit for maneuvering purposes.
The magnitudes of impulsive applications of force required to perturb the orbit by desired amounts is calculated for some typical cases, under the assumption of a central force field. From these results, the case of continuously applied forces may be derived.
The treatment is perfectly general, and permits analysis of the effects of arbitrary variations of an arbitrary initial conical motion.
For a few typical cases, the corresponding requirements of propellant consumption of chemical rockets is shown.
An Investigation of Dry Adhesive Wear
Authors: Steijn R. P. 
Published: May 2019

Sliding-motion experiments under unlubricated conditions have been carried out on various metals, and the results are discussed in terms of the simple wear theory advanced by Archard.
Oxide-film formation has been studied by electrical contact-resistance measurements made in conjunction with wear tests. The effects on the wear rate and basic wear formula are discussed. For the ring apparatus, a modified expression for the wear formula is suggested to incorporate surface oxidation.
Although it was found that the sliding of a soft material on a hard material follows simple wear rules, discrepancies are reported for the wear of brass against brass. In these experiments, the wear rate is affected by the geometry of the apparent area of contact.
The Applicability of the ASME Boiler and Pressure Vessel Code, Section XII, Transport Tanks, for Use in U.S. Federal Maritime Regulations
Authors: Selz Allen , Sharp Daniel R. 
Published: May 2019

Developed at the request of the US Department of Transportation, Section XII-Transport Tanks, of the ASME Boiler and Pressure Vessel Code addresses rules for the construction and continued service of pressure vessels for the transportation of dangerous goods by road, air, rail, or water. The standard is intended to replace most of the vessel design rules and be referenced in the federal hazardous material regulations, Title 49 of the Code of Federal Regulations (CFR). While the majority of the current rules focus on over-the-road transport, there are rules for portable tanks which can be used in marine applications for the transport of liquefied gases, and for ton tanks used for rail and barge shipping of chlorine and other compressed gases. Rules for non-cryogenic portable tanks are currently provided in Section VIII, Division 2, but will be moved into Section XII. These portable tank requirements should also replace the existing references to the outmoded 1989 edition of ASME Section VIII, Division 1 cited in Title 46 of the CFR.
Paper published with permission.
Mitigation of Piping System Vibration Using Dynamic Restraints
Authors: Voll Brian 
Published: May 2019

Most power plant piping systems experience some level of vibration during operation. In some cases, the addition of restraints is required to keep operational vibration levels within acceptable limits. Vibration levels may need to be controlled to limit stresses in the piping or attached components, minimize wear on supports or other components, or prevent impacts with other piping or components. This paper discusses the use of dynamic restraints to effectively mitigate piping-system vibrations. Topics covered include: The effectiveness of using dynamic restraints for various sources of vibration; the effectiveness and applicability of various types of dynamic restraints; design considerations, including sizing and placement of dynamic restraints; and maintenance and testing considerations for dynamic restraints.
Paper published with permission.
Breast cancer risk in transgender people receiving hormone treatment: nationwide cohort study in the Netherlands
Authors: de Blok Christel J M , Wiepjes Chantal M , Nota Nienke M , van Engelen Klaartje , Adank Muriel A , Dreijerink Koen M A , Barbé Ellis , Konings Inge R H M , den Heijer Martin 
Published: May 2019

AbstractObjectiveTo investigate the incidence and characteristics of breast cancer in transgender people in the Netherlands compared with the general Dutch population.DesignRetrospective, nationwide cohort study.SettingSpecialised tertiary gender clinic in Amsterdam, the Netherlands.Participants2260 adult trans women (male sex assigned at birth, female gender identity) and 1229 adult trans men (female sex assigned at birth, male gender identity) who received gender affirming hormone treatment.Main outcome measuresIncidence and characteristics (eg, histology, hormone receptor status) of breast cancer in transgender people.ResultsThe total person time in this cohort was 33 991 years for trans women and 14 883 years for trans men. In the 2260 trans women in the cohort, 15 cases of invasive breast cancer were identified (median duration of hormone treatment 18 years, range 7-37 years). This was 46-fold higher than in cisgender men (standardised incidence ratio 46.7, 95% confidence interval 27.2 to 75.4) but lower than in cisgender women (0.3, 0.2 to 0.4). Most tumours were of ductal origin and oestrogen and progesterone receptor positive, and 8.3% were human epidermal growth factor 2 (HER2) positive. In 1229 trans men, four cases of invasive breast cancer were identified (median duration of hormone treatment 15 years, range 2-17 years). This was lower than expected compared with cisgender women (standardised incidence ratio 0.2, 95% confidence interval 0.1 to 0.5).ConclusionsThis study showed an increased risk of breast cancer in trans women compared with cisgender men, and a lower risk in trans men compared with cisgender women. In trans women, the risk of breast cancer increased during a relatively short duration of hormone treatment and the characteristics of the breast cancer resembled a more female pattern. These results suggest that breast cancer screening guidelines for cisgender people are sufficient for transgender people using hormone treatment.
Mixed-methods study in England and Northern Ireland to understand young men who have sex with men’s knowledge and attitudes towards human papillomavirus vaccination
Authors: Kesten Joanna May , Flannagan Carrie , Ruane-McAteer Eimear , Merriel Samuel William David , Nadarzynski Tom , Shapiro Gilla , Rosberger Zeev , Prue Gillian 
Published: May 2019

ObjectivesMen who have sex with men (MSM) are at greater risk for human papillomavirus (HPV)-associated cancers. Since 2016, MSM have been offered the HPV vaccination, which is most effective when received prior to sexual debut, at genitourinary medicine clinics in the UK. In September 2019, the national HPV vaccination programme will be extended to boys. This study aimed to understand young MSM’s (YMSM) knowledge and attitudes towards HPV vaccination.DesignQuestionnaires assessed YMSM demographics, sexual behaviour, culture, knowledge and attitudes towards HPV vaccination and stage of vaccine decision-making using the precaution adoption process model. Focus groups explored sexual health information sources, attitudes, barriers and facilitators to vaccination and strategies to support vaccination uptake. Questionnaire data were analysed using descriptive statistics and focus group data were analysed thematically.SettingQuestionnaires were completed online or on paper. Focus groups were conducted within Lesbian Gay Bisexual Transgender Queer organisational settings and a university student’s union in England and Northern Ireland.ParticipantsSeventeen YMSM (M=20.5 years) participated in four focus groups and 51 (M=21.1 years) completed questionnaires.ResultsOver half of YMSM were aware of HPV (54.9%), yet few (21.6%) had previously discussed vaccination with a healthcare professional (HCP). Thematic analyses found YMSM were willing to receive the HPV vaccine. Vaccination programmes requiring YMSM to request the vaccine, particularly prior to sexual orientation disclosure to family and friends, were viewed as unfeasible. Educational campaigns explaining vaccine benefits were indicated as a way to encourage uptake.ConclusionsThis study suggests that to effectively implement HPV vaccination for YMSM, this population requires clearer information and greater discussion with their HCP. In support of the decision made by the Joint Committee on Vaccination and Immunisation, universal vaccination is the most feasible and equitable option. However, the absence of a catch-up programme will leave a significant number of YMSM at risk of HPV infection.
Protocol for the development of a core indicator set for reporting burn wound infection in trials: ICon-B study
Authors: Davies Anna , Teare Louise , Falder Sian , Coy Karen , Dumville Jo C , Collins Declan , Moore Luke , Dheansa Baljit , Jenkins A Toby A , Booth Simon , Agha Riaz , Shah Mamta , Marlow Karen , Young Amber 
Published: May 2019

IntroductionSystematic reviews of high-quality randomised controlled trials are necessary to identify effective interventions to impact burn wound infection (BWI) outcomes. Evidence synthesis requires that BWI is reported in a consistent manner. Cochrane reviews investigating interventions for burns report that the indicators used to diagnose BWI are variable or not described, indicating a need to standardise reporting. BWI is complex and diagnosed by clinician judgement, informed by patient-reported symptoms, clinical signs, serum markers of inflammation and bacteria in the wound. Indicators for reporting BWI should be important for diagnosis, frequently observed in patients with BWI and assessed as part of routine healthcare. A minimum (core) set of indicators of BWI, reported consistently, will facilitate evidence synthesis and support clinical decision-making.AimsThe Infection Consensus in Burns study aims to identify a core indicator set for reporting the diagnosis of BWI in research studies.Methods(1) Evidence review: a systematic review of indicators used in trials and observational studies reporting BWI outcomes to identify a long list of candidate indicators; (2) refinement of the long list into a smaller set of survey questions with an expert steering group; (3) a two-round Delphi survey with 100 multidisciplinary expert stakeholders, to achieve consensus on a short list of indicators; (4) a consensus meeting with expert stakeholders to agree on the BWI core indicator set.Ethics and disseminationParticipants will be recruited through professional bodies, such that ethical approval from the National Health Service (NHS) Health Research Authority (HRA) is not needed. The core indicator set will be disseminated through peer-reviewed publication, co-production with journal editors, research funders and professional bodies, and presentation at national conferences.PROSPERO registration numberCRD42018096647.
Efficacy and acceptability of adjunctive psychological and pharmacological interventions for treatment-resistant depression: protocol for a systematic review and network meta-analysis
Authors: Husain Muhammad Ishrat , Strawbridge Rebecca , Carter Ben , Jones Brett D M , Young Allan , Carvalho Andre F 
Published: May 2019

IntroductionMajor depressive disorder (MDD) is a common debilitating illness worldwide. The vast majority of patients with MDD will not achieve remission with first-line treatment and despite the availability of different treatment modalities, at least one-third of patients experience treatment-resistant depression (TRD). There continues to be a paucity of research focused on treatment options for patients with TRD thus treatment decisions are largely based on patient and clinician preference as opposed to evidence-based practice. Herein we propose a systematic review and network meta-analysis (NMA) of available pharmacological and psychological augmentation treatments for TRD, to inform evidence-based management of TRD.Methods and analysisWe plan to conduct a search of electronic databases (MEDLINE and ISIWEB) of all dates from inception for randomised controlled trials of pharmacological and psychological augmentation interventions for adults with TRD. Articles for review will be included based upon consensus from two authors. Pharmaceutical companies will be contacted for access to any unpublished data. An NMA will compare the effectiveness pharmacological adjunctive agents for TRD using preanalysis/postanalysis, assuming consistency and transitivity.Ethics and disseminationThis project does not require research ethics board approval. The dissemination plan is to present findings at international scientific meetings and publishing results in a peer-reviewed academic journal.PROSPERO registration numberCRD42019132588.
Dual antiplatelet therapy in non-ST elevation acute coronary syndromes at Veterans Affairs Hospitals
Authors: Valle Javier Alfonso , Josey Kevin , Prouse Andrew F , Zimmet Jeffrey , Waldo Stephen W 
Published: May 2019

ObjectiveCurrent guidelines recommend that patients with non-ST elevation acute coronary syndromes (NSTEACS) receive dual antiplatelet therapy (DAPT) early in hospitalisations. However, observational studies suggest that this rarely occurs. We evaluated site-specific variation and clinical outcomes associated with early DAPT among patients undergoing angiography for NSTEACS.MethodsIn this observational analysis, we identified patients undergoing angiography for NSTEACS in Veterans Affairs hospitals from 2008 to 2016 and assessed characteristics and site variation associated with early DAPT (administration <24 hours of admission). Using propensity matching, we compared time to revascularisation, recurrent myocardial infarction (MI) and mortality between those receiving early DAPT and those not receiving early DAPT (administration ≥24 hours).ResultsOf 45 569 patients undergoing angiography for NSTEACS, 15 084 (33%) received early DAPT. Early DAPT was more frequent in patients with non-ST elevation MI, prior surgical revascularisation and among patients undergoing revascularisation. There was a greater than twofold difference in early DAPT across sites, independent of patient characteristics (median OR 2.43, 95% CI 2.28 to 2.55). There was no difference in time topercutaneous coronary intervention (PCI) between groups, but a significant delay to surgical revascularisation with early DAPT (median 4 vs 3 days, p<0.001) without reduction in hazard of death or MI (HR 1.08, 95% CI 1.00 to 1.16) and similar results demonstrated in the subgroup of patients undergoing revascularisation (HR 1.02, 95% CI 0.91 to 1.13).ConclusionAmong NSTEACS patients undergoing coronary angiography, early DAPT was not associated with improvement of outcomes but was associated with delays in surgical revascularisation.