bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost associated with hematopoietic stem cell transplantation: a retrospective claims data analysis in Germany
Authors: Mayerhoff Lukas , Lehne Moritz , Hickstein Lennart , Salimullah Tayyab , Prieur Sigurd , Thomas Simu K , Zhang Jie 
Published: December 2018

Aim:
Quantify hematopoietic stem cell transplantation (HSCT) costs in German patients with acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL).
Methods:
The primary outcome was direct and indirect costs in patients with ALL/DLBCL/FL who received HSCT between 2010 and 2014. Costs were evaluated two to four quarters before to eight quarters after HSCT.
Results:
Among 258 patients with HSCT, direct costs were €290,125/patient (pediatric ALL), €246,266/patient (adult ALL), €230,399/patient (DLBCL/FL allogeneic) and €107,457/patient (DLBCL/FL autologous). Indirect costs with HSCT were €52,939/patient (adult ALL), €20,285/patient (DLBCL/FL allogeneic) and €29,881/patient (DLBCL/FL autologous).
Conclusion:
Direct and indirect costs associated with HSCT are substantial for patients with ALL, DLBCL and FL. Novel therapies that reduce HSCT use could reduce medical costs.
La obsidiana como un bien de intercambio entre el valle de Toluca y sus regiones circunvecinas durante el Clásico
Authors: Sugiura Yamamoto Yoko , Jaimes Vences Gustavo , Kabata Omoya Shigeru , Glascock Michael 
Published: December 2018

<p>La relación entre Teotihuacan, Estado que dominó durante siglos una vasta región mesoamericana, y el valle de Toluca, que formó parte de su hinterland, ha sido fundamental para esclarecer los procesos históricos de este valle. Dicha relación se hace presente en la cultura material por múltiples manifestaciones, desde la vida cotidiana hasta la cosmovisión. Este estudio se centra en torno a la problemática rela-<br /> cionada con la circulación de la obsidiana, la cual constituye uno de los temas relevantes para lograr una aproximación correcta a los procesos históricos del Altiplano central de México. Se ha propuesto que el control sobre algunos yacimientos y la circulación de esta materia prima, considerada insustituible en las sociedades prehispánicas, ha sido primordial para el desarrollo del Estado teotihuacano. El presente escrito estudia el vínculo que se establece entre el valle y el gran Estado con base en los análisis de la obsidiana de diversos yacimientos identificados mediante la revisión macroscópica, así como por la aplicación del INAA y XRF al material proveniente de excavaciones de los sitios con cronología comprendida entre el Clásico y el Epiclásico: Santa Cruz Atizapán y San Mateo Atenco. Éste se compara, a su vez, con el material de algunos contextos teotihuacanos con el fin de esclarecer la implicación histórica en la relación entre ambas regiones en el ámbito del intercambio.</p><div> </div>
Solución concertada de conflictos territoriales al interior de la provincia del Cañar
Authors: Palomeque Cantos René Patricio , Quevedo Quinteros Manuel Ramiro , Molina Hugo Jhon Genaro 
Published: December 2018

<p>El Consejo de la Judicatura de Ecuador, luego de verificar el cumplimiento de requisitos legales, autorizó la creación y funcionamiento, del Centro de Mediación de la Universidad Católica de Cuenca, sede Azogues, lo cual permitió iniciar toda una actividad para contribuir a la solución de diferentes problemas sociales, territoriales, culturales, legales, etcétera, mediante la aplicación de la cultura del diálogo, entendimiento y paz, aspectos que buscan el Buen Vivir, determinado en su Constitución Política vigente.</p><p>El trabajo de investigación aborda el caso de la delimitación territorial de los cantones de Déleg, Azogues, Biblián, Suscal y Cañar; sustentado en encuestas de opinión, mediante cifras y cuadros estadísticos, evidencia la gran aceptación popular al modelo aplicado en la solución de sus conflictos bajo el criterio de concesión y beneficio hacia el desarrollo. Estos pueblos, a partir de en-<br /> tonces, han iniciado su gestión gubernativa plenamente integrados a su identidad, heredad, cultura y territorialidad, con mayor criterio de integración nacional hacia el desarrollo. </p>
La relación entre patrimonio cultural y pueblos indígenas.
Authors: Oehmichen Bazán Cristina 
Published: December 2018

<p>Uno de los temas que hoy se discuten en el ámbito latinoamericano, es el de la relación entre patrimonio cultural y pueblos indígenas. A partir del reconocimiento constitucional de los derechos indígenas en diversos países, así como la aprobación del Convenio 169 de la OIT y de la Declaración de los Derechos Humanos de los Pueblos Indígenas, se analizan los derechos de los pueblos indígenas respecto al patrimonio cultural del pasado, sean los monumentos arqueológicos, los vestigios de la época precolombina y todos aquellos objetos de la cultura material museográfica. El espectro de la discusión es tan amplio y polifacético, que puede ser abordado desde diversas perspectivas. Es por ello que hay que agradecer a un grupo de investigadores chilenos que se unieron para reflexionar al respecto y publicaron en libro “Patrimonio y pueblos indígenas. Reflexiones desde una perspectiva interdisciplinaria e intercultural” de Margarita Alvarado, Luis Campos, Francisco Gallardo y otros, CIIR, Pehuén Editores S.A., ISBN 978-956-16-0664-7, Chile 2016, 215 pág. </p>
As tropas de ordenanças na Ilha de Santa Catarina durante os setecentos
Authors: Mendes Jeferson Dos Santos 
Published: December 2018

O presente trabalho, de forma introdutória, busca analisar as tropas de ordenanças na Ilha de Santa Catarina. As condições desses regimentos relatados pelos viajantes europeus de passagem pela Ilha durante os séculos XVIII e XIX, além das nomeações realizadas pelos governadores e as dificuldades de organizar um corpo militar. Por outro lado, muito rapidamente vamos tratar da importância da Ilha de Santa Catarina no contexto do século XVIII e suas funções estratégicas e militares na geopolítica colonial.
A randomized clinical trial to evaluate the plaque removal efficacy of an oscillating-rotating toothbrush versus a sonic toothbrush in orthodontic patients using digital imaging analysis of the anterior dentition
Authors: Erbe Christina , Jacobs Collin , Klukowska Malgorzata , Timm Hans , Grender Julie , Wehrbein Heinrich 
Published: December 2018

ABSTRACT

Objective:
To compare the plaque removal efficacy of an oscillating-rotating electric toothbrush with an orthodontic brush head versus a sonic toothbrush in adolescent patients with fixed orthodontic appliances.

Materials and Methods:
This was a randomized, examiner-blind, replicate single-use, two-treatment, four-period, crossover study with a washout period between visits of approximately 24 hours. Forty-four adolescent patients with fixed orthodontic appliances in both arches were randomized based on a computer-generated randomization schedule to one of four toothbrush treatment sequences. The primary outcome was plaque score change from baseline, measured using digital plaque imaging analysis.

Results:
Baseline plaque levels for both brush treatments were high, covering more than 50% of the tooth area. Effective plaque removal was observed with both brush treatments (P &lt; .001); however, the reduction in plaque with the oscillating-rotating toothbrush was statistically significantly greater (P = .017) compared with the sonic toothbrush.

Conclusions:
The study provides evidence for more effective plaque-removing efficacy of the oscillating-rotating toothbrush versus the sonic toothbrush among orthodontic patients.
Clinical Evaluation of Two Different Prevention Programs in Adults Depending on Their Caries Risk Profile: One-year Results
Authors: Achilleos E , Rahiotis C , Kavvadia K , Vougiouklakis G 
Published: December 2018

SUMMARYThe aim of this study was to investigate the management of incipient caries lesions in adults with two preventive protocols. A total of 44 adult patients with high, moderate and low caries risk with 516 incipient caries took part in the study. These patients were assessed for caries with International Caries Detection and Assessment System (ICDAS) criteria and were then divided into three groups depending on their caries risk profile: a high-risk group (group A), a moderate-risk group (group B), and a low-risk group (group C). Participants in each group were further divided randomly into two subgroups. In subgroups A1, B1, and C1, an intensive preventive protocol was applied, while in subgroups A2, B2, and C2, the protocol consisted only of instructions in oral hygiene. The invasive-intensive protocol included the topical application of fluoride, brushing with 5000-ppm fluoride toothpaste, use of amorphous calcium phosphate-casein phosphopeptide, applications of sealants for occlusal lesions (ICDAS code 2), and minimal resin restorations for occlusal lesions (ICDAS code 3). There was no statistically significant difference in the number of lesions (baseline and after one year) in the high-risk and moderate-risk groups that received the intensive protocol (groups A1 and B1), while the control groups were statistically significant different (groups A2 and B2). In the low-risk group, there was no statistically significant difference in the number of lesions (groups C1 and C2). The two different preventive protocols in the high- and moderate-risk groups presented differences in effectiveness, while in the low-risk group, no significant difference was demonstrated.
Impact of Recently Developed Universal Adhesives on Tensile Bond Strength to Computer-aided Design/Manufacturing Ceramics
Authors: Liebermann A , Detzer J , Stawarczyk B 
Published: December 2018

SUMMARY

Objectives:
The aim of this investigation was to test the tensile bond strength (TBS) between different computer-aided-design/manufacturing (CAD/CAM) ceramics after conditioning using different universal adhesive systems and resin composite cement.

Methods and Materials:
Substrates of four CAD/CAM ceramics—1) VITABLOCS Mark II, 2) Initial LRF, 3) Celtra Duo, and 4) IPS e.max CAD (N=648, n=162)—were fabricated. VITABLOCS Mark II and Initial LRF were etched using 9% hydrofluoric acid for 60 seconds, Celtra Duo for 30 seconds, and IPS e.max CAD for 20 seconds. Substrates for conditioning using Monobond Etch & Prime were untreated. The following adhesive systems were used: All-Bond Universal (ABU), Clearfil Universal Bond (CUB), G-Multi Primer (GMP), iBond Universal (IBU), Monobond Etch & Prime (MEP), Monobond Plus (MBP), One Coat 7 Universal (OCU), Prime&Bond Active (PBA), and Scotchbond Universal (SBU). Conditioned substrates were bonded using a resin composite cement (Variolink Esthetic DC), thermal cycled (20,000×, 5°C/55°C), and TBS was measured using a universal testing machine. Data were analyzed using univariate analysis with partial eta-squared, Kolmogorov-Smirnov, Kruskal-Wallis, Mann-Whitney U, and Spearman-Rho tests (α=0.05).

Results:
ABU, MEP, and MBP obtained the significantly highest TBS, while CUB, IBU, and OCO resulted in the lowest, regardless of the CAD/CAM ceramic. SBU showed varying TBS results depending on the CAD/CAM ceramic used. ABU, MEP, and MBP showed no impact of CAD/CAM ceramic on TBS values. ABU, GMP, MEP, and MBP showed predominantly cohesive failure types in luting composite, while CUB and OCU demonstrated adhesive failure types.
Large-scale implementation and adoption of the Finnish national Kanta services in 2010–2017: a prospective, longitudinal, indicator-based study
Authors: Jormanainen Vesa 
Published: December 2018

In Finland, implementation and adoption of the national Kanta services’ second phase services were carried out step-by-step from May 2010 till December 2017. The Kanta services currently include integrated, interoperable health information from EMR, EHR, PHR and social welfare sources that can benefit patients, care providers and policy makers. In Finland, the Ministry of Social Affairs and Health steers the Kanta services, and was responsible of the first phase implementation activities since July 2007. For the second phase of implementation and adoption of the services, a new national operational coordination function was established by law in January 2011. The adoption and implementation of the Kanta services would not have been possible without joint efforts of stakeholders and provision of adequate (state) funding. A set of indicators for various prospective, longitudinal monthly follow-up were used. The current principal Kanta services include My Kanta Pages (since May 2010), Prescription Centre (May 2010), Pharmaceutical Database (May 2010), Patient Data Repository and Patient Data Management Service (November 2013), Kelain (September 2016), and Client Data Archive for Social Welfare Services (May 2018) and Kanta Personal Health Record (May 2018).
Pengembangan Pengembangan Pendidikan Karakter Melalui Pelayanan BK di Sekolah
Authors: Mafirja Sulma 
Published: December 2018

Abstrak: Pendidikan karakter merupakan salah satu gerakan pendidikan di sekolah untuk memperkuat karakter siswa melalui harmonisasi olah hati (etika), olah rasa (estetika), olah pikiran (literasi), dan olah raga (kinesteti) dengan dukungan melibatkan publik dan kerja sama antar sekolah, keluarga, dan masyarakat. Sementara layanan bimbingan dan konseling merupakan salah satu program layanan yang turut andil dalam pelaksanaan program di sekolah. Sehingga diharapkan implementasi penguatan pendidikan karakter melalui pelayanan BK di sekolah dapat dilaksanakan dan diterapkan dengan efektif dan efesian, agar dapat mencapai tujuan yang lebih optimal bagi perkembangan nilai-nilai karakter yang ada pada peserta didik.
Incidence of and risk factors for major complications or death in dogs undergoing cytoreductive surgery for treatment of suspected primary intracranial masses
Authors: Kohler Rickard J. , Arnold Susan A. , Eck Daniel J. , Thomson Christopher B. , Hunt Matthew A. , Pluhar G. Elizabeth 
Published: December 2018

Abstract
OBJECTIVE To determine incidence of and risk factors for major complications occurring in dogs within 30 days after cytoreductive surgery performed by a single pair of surgeons for treatment of suspected primary intracranial masses.
DESIGN Retrospective cohort study.
ANIMALS 160 client-owned dogs that underwent cytoreductive surgery for treatment of suspected primary intracranial masses between January 2009 and December 2015 at a veterinary teaching hospital.
PROCEDURES Medical records were retrospectively reviewed for complications occurring within 30 days after surgery. Data (eg, signalment, clinical signs, previous treatments, preoperative neurologic examination findings, neuroanatomical location, time from onset of clinical signs to surgery, surgical approach, and histopathologic diagnosis) were analyzed for associations with death and with development of major complications other than death.
RESULTS 21 (13.1%) dogs died (11 during hospitalization and 10 after discharge) and 30 (18.8%) developed major complications other than death during the first 30 days after surgery. Dogs with abnormal preoperative neurologic examination findings were more likely to develop complications or die. Dogs undergoing a suboccipital approach were more likely to die. The most common postoperative complications other than death were seizures (n = 18 [11.3%]), worsening of neurologic status (6 [3.8%]), and aspiration pneumonia (6 [3.8%]).
CONCLUSIONS AND CLINICAL RELEVANCE Results of the present study provided valuable information on predisposing factors, odds of major complications or death, and incidences of major complications or death in dogs during the first 30 days after undergoing cytoreductive surgery for treatment of suspected primary intracranial masses. Careful case selection may help improve outcomes and minimize complications.
Perforating foreign body in the ventriculus of a pet pigeon (Columba livia domestica)
Authors: Laniesse Delphine , Beaufrère Hugues , Mackenzie Shawn , Singh Ameet , Samman Ayman , Susta Leonardo 
Published: December 2018

Abstract
CASE DESCRIPTION A 2-year-old female pigeon was evaluated because of a 5-day history of lower than typical activity level, weight loss, and polyuria.
CLINICAL FINDINGS Whole-body radiography revealed a linear metallic foreign body in the area of the ventriculus. Fluoroscopy followed by contrast-enhanced CT was performed to further characterize the lesion location, revealing that the foreign body had perforated the ventral aspect of the ventriculus wall and that the ventral extremity of the foreign body was surrounded by a mass, consistent with a granuloma.
TREATMENT AND OUTCOME A midline celiotomy was performed, and a large granuloma was identified ventral to the ventriculus, adherent to the dorsal aspect of the keel bone. The metallic foreign body (a nail) was removed, and the content of the granuloma was debrided. Amoxicillin–clavulanic acid (150 mg/kg [68.2 mg/lb], PO, q 12 h for 10 days), meloxicam (1 mg/kg [0.45 mg/lb], PO, q 12 h for 5 days), and sucralfate (100 mg/kg [45 mg/lb], PO, q 8 h for 10 days) were prescribed. The pigeon made a successful recovery and was still doing well at a 1-year recheck evaluation.
CLINICAL RELEVANCE Although traumatic gastritis in pigeons has been reported, use of advanced diagnostic imaging for the pigeon of this report facilitated identification of the precise nature of the lesion and, therefore, surgical planning. The outcome for this pigeon suggested that successful resolution of traumatic gastritis may be possible in other affected birds with surgery.
Factors associated with yearling bulls passing subsequent breeding soundness evaluations after failing an initial evaluation
Authors: Monday Jessica D. , Larson Robert L. , Theurer Miles E. , White Brad J. , Tucker Sharon 
Published: December 2018

Abstract
OBJECTIVE To determine the proportion of yearling beef bulls classified as satisfactory potential breeders when reevaluated after failing an initial breeding soundness evaluation (BSE) and identify any factors at initial BSE that predicted satisfactory performance at reevaluation.
DESIGN Retrospective observational study.
ANIMALS 2,064 beef bulls between 11 and 14 months of age at first BSE, evaluated from 2006 to 2014.
PROCEDURES For each bull, data on age (categorized by month), breed, and BSE findings were extracted from the medical records. Bulls were classified as satisfactory potential breeders if they met Society for Theriogenology standards at the initial BSE or up to 2 subsequent reevaluations. Generalized linear mixed models were generated to assess potential associations between certain variables at initial BSE and passing that evaluation or passing subsequent BSEs after initial failure.
RESULTS 1,921 of 2,064 (93.1%) yearling bulls passed 1 of up to 3 BSEs. The proportion of yearling bulls that were not classified as satisfactory during initial BSE but were later classified as satisfactory was 143 of 287 (49.8%). A significant interaction was identified between bull age and breed in the probability of passing the initial evaluation. No variable, including breed, age, scrotal circumference per day of age, and spermatozoa morphology at initial BSE, significantly predicted passing subsequent reevaluations after failing an initial BSE.
CONCLUSIONS AND CLINICAL RELEVANCE Age and breed information should be considered when deciding the age at which initial BSE should be scheduled for a yearling bull cohort.
Use of equine amniotic membrane free-island grafts for treatment of a midstromal corneal ulcer and descemetocele in a snow leopard (Panthera uncia)
Authors: Knollinger Amy M. , McDonald Jessica E. , Carpenter Nancy A. , Crook Erika K. 
Published: December 2018

Abstract
CASE DESCRIPTION A 7-year-old sexually intact female snow leopard (Panthera uncia) was examined because of blepharospasm, periocular discharge, ventral deviation of the upper eyelid cilia, third eyelid prolapse, and corneal opacity of the right eye.
CLINICAL FINDINGS An ophthalmic examination performed with the patient anesthetized revealed a 3 × 3-mm ulcer that extended approximately 60% of the depth of the right cornea and was accompanied by perilesional and intralesional cellular infiltrates and active vascularization. The upper eyelid of the right eye also had a previously repaired coloboma resulting in trichiasis.
TREATMENT AND OUTCOME Surgical intervention was elected after 5 weeks of medical management including topical administration of autologous serum and topical, subconjunctival, and systemic administration of antimicrobials failed to yield any improvement in the ulcer. Equine amniotic membrane free-island graft placement and eyelid revision surgeries were performed. Two and a half weeks later, a descemetocele was diagnosed ventrolateral to the original ulcer, and a second equine amniotic membrane free-island grafting procedure was performed. Both grafts healed without further intervention.
CLINICAL RELEVANCE Equine amniotic membrane free-island grafts were used to successfully repair a corneal ulcer and descemetocele in a snow leopard. The grafting procedure spared the affected globe and resulted in satisfactory cosmesis and functional vision. This procedure should be considered as an option for corneal repair in nondomestic species for which postoperative care and medical treatment options are limited.
Aging concrete structures: a review of mechanics and concepts
Authors: Wan-Wendner Roman 
Published: December 2018

Summary
The safe and cost-efficient management of our built infrastructure is a challenging task considering the expected service life of at least 50 years. In spite of time-dependent changes in material properties, deterioration processes and changing demand by society, the structures need to satisfy many technical requirements related to serviceability, durability, sustainability and bearing capacity. This review paper summarizes the challenges associated with the safe design and maintenance of aging concrete structures and gives an overview of some concepts and approaches that are being developed to address these challenges.
Avian poxvirus infection in Polish great tits (Parus major)
Authors: Kozdruń Wojciech , Styś-Fijoł Natalia , Czekaj Hanna , Indykiewicz Piotr , Sandecki Rafał , Niczyporuk Jowita Samanta 
Published: December 2018

Abstract

Introduction: Avian poxvirus infections are widespread in the domestic poultry population but are also reported in wild birds. In poultry, these infections cause significant economic losses, while wild birds may be a reservoir for poxvirus which affects breeding poultry. However, wild birds may also exhibit characteristic anatomopathological changes. This study concerns the infection of wild-living great tits (Parus major) with the avian poxvirus in Poland.

Material and Methods: Samples of internal organs and skin collected from great tits were homogenised and total cellular DNA was isolated. In PCR, the primers complementary to gene encoding the core protein 4b of the HP44 strain of fowl poxvirus (FPV) were used.

Results: After electrophoresis in 2% agarose gel, the PCR product of 578 bp characteristic for FPV was obtained in DNA samples isolated from skin lesions and the heart. The analysis of the nucleotide sequence of the virus strain showed 99% similarity to many poxviruses previously isolated from great tits and other free birds at various sites in the world.

Conclusions: This paper is the first clinically documented evidence obtained in laboratory conditions of avian poxvirus cases in great tits in Poland.