bluuebunny/crossref_metadata_2025_split huggingface dataset:
Like or want? Gender differences in attitudes toward online shopping in China
Authors: Dai Wanwen , Arnulf Jan K. , Iao Laileng , Wan Pei , Dai Haojin 
Published: January 2019

AbstractWhile previous studies indicate that female consumers display less trust for online shopping than males do, there is little research to addresses the reasons behind this difference. Our study applies a combination of both self‐report and the Implicit Association Test (IAT) to compare the cognitive and affective components of attitudes in men and women toward online shopping in China. Although female participants showed no significant difference from male participants in affective attitudes toward online shopping in the self‐report condition, females associated online shopping more frequently with unpleasant adjectives and off‐line shopping with pleasant adjectives in the indirect IAT condition. The opposite pattern was found for the male group. This finding indicates a wanting but disliking attitude toward online shopping among the female consumers in China, which provides a unique theoretical contribution to consumer behavior theory and helps to enhance e‐marketers’ market targeting and segmentation effectiveness in China.
Consumers' engagement with social media activation campaigns: Construct conceptualization and scale development
Authors: Mirbagheri SeyedAlireza , Najmi Manoochehr 
Published: January 2019

AbstractThis study conceptualizes the consumers' engagement with social media activation campaigns, which are important tools in improving the interactions between brands and consumers. We offer a comprehensive definition of this construct and discuss the nature and dimensionality of it. Further, this paper reports the development and validation of a 12‐item scale for measuring the aforementioned construct. This scale development process comprises four studies. Study 1 begins by generating a pool of items and then employs both a panel of experts and some Instagram users to examine the content validity of the items. To validate the scale, this paper carries out several online surveys in subsequent studies. Study 2 uses exploratory and confirmatory factor analysis (CFA) to remove the problematic items and evaluate the dimensionality of the construct. In Study 3, we conduct iterative CFAs to purify the scale and reassess the psychometric properties of the scale. Study 4 uses structural equation modeling to test the nomological validity. Our analyses reveal that consumers' engagement with social media activation campaigns is a second‐order construct encompassing three first‐order dimensions (cognitive, emotional, and behavioral engagement). The results also support the reliability, content validity, convergent validity, discriminant validity, known group validity, and nomological validity of the engagement scale.
How do consumers categorize new hybrid products?
Authors: El Amri Dhouha 
Published: January 2019

AbstractThis article investigates how consumers categorize new hybrid products (NHPs). Given the limitations of the classical theories of categorization in the specific case of NHP, affordance, mobilized infrequently in marketing, turned out to be a useful categorization concept. Five types of NHP categorizations by consumers, based on the degree of affordance (low vs. high) and type of innovation (incremental vs. radical), have been detected and filled a gap in the literature on the subject.
How and when taking pictures undermines the enjoyment of experiences
Authors: Nardini Gia , Lutz Richard J. , LeBoeuf Robyn A. 
Published: January 2019

AbstractThe consumption of experiences (as opposed to products) has seen an increasing amount of research attention in recent years. A key aspect of the experiential consumption journey is how the experience is consumed. For instance, people almost invariably take pictures during highly enjoyable experiences such as vacations or important family events. Although past research has suggested that taking pictures may enhance the enjoyment of moderately enjoyable experiences, the effect of picture taking on the real‐time enjoyment of highly enjoyable experiences is not clear. To address this matter, the authors investigate whether taking pictures affects consumers’ enjoyment of highly enjoyable hedonic experiences. A series of laboratory studies demonstrate that taking pictures (compared with not taking pictures) can decrease enjoyment of highly enjoyable experiences. This study suggests that, by constantly striving to document their experiences, consumers may unwittingly fail to enjoy those experiences to the fullest. These results have implications for how firms may best stage experiential offerings to enhance their customers’ experiences.
Multidisciplinary approaches for targeting the secretase protein family as a therapeutic route for Alzheimer's disease
Authors: Schaduangrat Nalini , Prachayasittikul Veda , Choomwattana Saowapak , Wongchitrat Prapimpun , Phopin Kamonrat , Suwanjang Wilasinee , Malik Aijaz Ahmad , Vincent Bruno , Nantasenamat Chanin 
Published: January 2019

AbstractThe continual increase of the aging population worldwide renders Alzheimer's disease (AD) a global prime concern. Several attempts have been focused on understanding the intricate complexity of the disease's development along with the on‐ andgoing search for novel therapeutic strategies. Incapability of existing AD drugs to effectively modulate the pathogenesis or to delay the progression of the disease leads to a shift in the paradigm of AD drug discovery. Efforts aimed at identifying AD drugs have mostly focused on the development of disease‐modifying agents in which effects are believed to be long lasting. Of particular note, the secretase enzymes, a group of proteases responsible for the metabolism of the β‐amyloid precursor protein (βAPP) and β‐amyloid (Aβ) peptides production, have been underlined for their promising therapeutic potential. This review article attempts to comprehensively cover aspects related to the identification and use of drugs targeting the secretase enzymes. Particularly, the roles of secretases in the pathogenesis of AD and their therapeutic modulation are provided herein. Moreover, an overview of the drug development process and the contribution of computational (in silico) approaches for facilitating successful drug discovery are also highlighted along with examples of relevant computational works. Promising chemical scaffolds, inhibitors, and modulators against each class of secretases are also summarized herein. Additionally, multitarget secretase modulators are also taken into consideration in light of the current growing interest in the polypharmacology of complex diseases. Finally, challenging issues and future outlook relevant to the discovery of drugs targeting secretases are also discussed.
Increased Consumption of Virgin Olive Oil, Nuts, Legumes, Whole Grains, and Fish Promotes HDL Functions in Humans
Authors: Hernáez Álvaro , Sanllorente Albert , Castañer Olga , Martínez‐González Miguel Á. , Ros Emilio , Pintó Xavier , Estruch Ramón , Salas‐Salvadó Jordi , Corella Dolores , Alonso‐Gómez Ángel M. , Serra‐Majem Lluis , Fiol Miquel , Lapetra José , Gómez‐Gracia Enrique , de la Torre Rafael , Lamuela‐Raventós Rosa‐María , Fitó Montserrat 
Published: January 2019

ScopeTo evaluate whether increases in the consumption of cardioprotective food groups (virgin olive oil, nuts, fruits/vegetables, legumes, whole grains, fish, and wine) are associated with improvements in high‐density lipoprotein (HDL) functions in high cardiovascular risk subjects.Methods and ResultsThe association between 1‐year changes in food group consumption and HDL functionality traits in 296 high cardiovascular risk subjects is assessed. Increases in virgin olive oil (10 g d–1) and whole grain consumption (25 g d–1) are associated with increments in cholesterol efflux capacity (+0.7%, P = 0.026, and +0.6%, P = 0.017, respectively). Increases in nut (30 g d–1) and legume intake (25 g d–1) are linked to increments in paraoxonase‐1 activity (+12.2%, P = 0.049, and +11.7%, P = 0.043, respectively). Legume intake increases are also related to decreases in cholesteryl ester transfer protein activity (–4.8%, P = 0.028). Fish consumption increments (25 g d–1) are associated with increases in paraoxonase‐1 activity (+3.9%, P = 0.030) and declines in cholesteryl ester transfer protein activity (–1.6%, P = 0.021), HDL cholesterol concentrations (–1.1%, P = 0.039), and functions related to HDL levels (cholesterol efflux capacity, –1.1%, P = 0.010).ConclusionIncreases in the consumption of virgin olive oil, nuts, legumes, whole grains, and fish (achievable through a regular diet) were associated with improvements in HDL functions in high cardiovascular risk subjects.
Preservice teachers’ self‐efficacy in managing students with symptoms of attention deficit/hyperactivity disorder: The roles of diagnostic label and students’ gender
Authors: Lee Ka Wai , Cheung Rebecca Y. M. , Chen Ming 
Published: January 2019

AbstractThe present study investigated preservice teachers’ self‐efficacy in classroom management involving students with symptoms of Attention Deficit/Hyperactivity Disorder (ADHD). A total of 137 Chinese preservice teachers were randomly presented with one of four vignettes involving a student character with ADHD symptoms, with manipulations including the character’s gender and diagnostic label of ADHD. Upon reading the vignette, participants responded to questions concerning their self‐efficacy in inclusive classroom management involving the character. Findings based on analysis of covariance indicated an interaction effect of the vignette character’s gender and label on teachers’ self‐efficacy. Specifically, teachers perceived greater self‐efficacy in a classroom involving a girl with an ADHD label than in a classroom involving a girl with no label or a boy with a label. Findings enriched the literature concerning the roles of gender and label in preservice teachers’ self‐efficacy toward inclusive classroom management.
Ramachandran maps for side chains in globular proteins
Authors: Rose George D. 
Published: January 2019

AbstractThe Ramachandran plot for backbone ϕ,ψ‐angles in a blocked monopeptide has played a central role in understanding protein structure. Curiously, a similar analysis for side chain χ‐angles has been comparatively neglected. Instead, efforts have focused on compiling various types of side chain libraries extracted from proteins of known structure. Departing from this trend, the following analysis presents backbone‐based maps of side chains in blocked monopeptides. As in the original ϕ,ψ‐plot, these maps are derived solely from hard‐sphere steric repulsion. Remarkably, the side chain biases exhibit marked similarities to corresponding biases seen in high‐resolution protein structures. Consequently, some of the entropic cost for side chain localization in proteins is prepaid prior to the onset of folding events because conformational bias is built into the chain at the covalent level. Furthermore, side chain conformations are seen to experience fewer steric restrictions for backbone conformations in either the α or β basins, those map regions where repetitive ϕ,ψ‐angles result in α‐helices or strands of β‐sheet, respectively. Here, these α and β basins are entropically favored for steric reasons alone; a blocked monopeptide is too short to accommodate the peptide hydrogen bonds that stabilize repetitive secondary structure. Thus, despite differing energetics, α/β‐basins are favored for both monopeptides and repetitive secondary structure, underpinning an energetically unfrustrated compatibility between these two levels of protein structure.
Medical simulation in pharmacology learning and retention: A comparison study with traditional teaching in undergraduate medical students
Authors: Arcoraci Vincenzo , Squadrito Francesco , Altavilla Domenica , Bitto Alessandra , Minutoli Letteria , Penna Olivia , Amato Antonio , Bruno Rosario , Tripodi Vincenzo Francesco , Alibrandi Angela , Ingrassia Pier Luigi , Santalucia Paola , Fodale Vincenzo 
Published: January 2019

AbstractThe purpose of the study was to determine whether low‐high fidelity medical simulation improves learning and long‐lasting retention of pharmacology knowledge, compared to lecture alone, in undergraduate medical students. Ninety students, before a 45‐minute lecture, were randomized into three groups ‐ sham (S), low (LF), and high fidelity (HF) simulation ‐ to participate in an interactive simulation session. To evaluate immediate and long‐lasting retention, a 20‐item structured questionnaire on inotropic agents was administered to 90 students before and after a 45‐minute lecture, after simulation, and 3 months later. In all groups, the rate of correct answers increased after lecture, while no difference was observed between different groups (P = 0.543). After simulation, students in the HF group provided more correct answers compared to S or LF group (P > 0.001). After 3 months, a significant decrease in the number of correct answers was observed in S (P < 0.001) and LF (P < 0.001) groups, but not in the HF group (P = 0.066). Moreover, HF simulation resulted in an increased number of correct answers compared to the LF (P < 0.001) or S simulation (P < 0.001). These data suggest that advanced medical simulation teaching applied to pharmacology is associated with more effective learning and long‐lasting retention compared to lecture alone.
Robust disturbance rejection for repetitive control systems with time‐varying nonlinearities
Authors: Yu Pan , Liu Kang‐Zhi , She Jinhua , Wu Min , Nakanishi Yosuke 
Published: January 2019

SummaryThis paper presents a disturbance‐rejection method for a modified repetitive control system with a nonlinearity. Taking advantage of stable inversion, an improved equivalent‐input‐disturbance (EID) estimator that is more relaxed for system design is developed to estimate and cancel out the influence of the disturbance and nonlinearity in the low‐frequency domain. The high‐frequency influence is filtered owning to the low‐pass nature of the linear part of the closed‐loop system. To avoid the restrictive commutative condition and choose a Lyapunov function of a more general form, a new design algorithm, which takes into account the relation between the feedback control gains and the observer and improved EID estimator gains, is developed for the nonlinear system. Furthermore, comparisons with the generalized extended‐state observer (GESO) and conventional EID methods are conducted. A clear relation between the developed estimator and the GESO is also clarified. Finally, simulations show the effectiveness and the advantage of the developed method.
Adaptive neural integral sliding‐mode control for tracking control of fully actuated uncertain surface vessels
Authors: Van Mien 
Published: January 2019

SummaryThis paper develops a novel adaptive neural integral sliding‐mode control to enhance the tracking performance of fully actuated uncertain surface vessels. The proposed method is built based on an integrating between the benefits of the approximation capability of neural network (NN) and the high robustness and precision of the integral sliding‐mode control (ISMC). In this paper, the design of NN, which is used to approximate the unknown dynamics, is simplified such that just only one simple adaptive rule is needed. The ISMC, which can eliminate the reaching phase and offer higher tracking performance compared to the conventional sliding‐mode control, is designed such that the system robust against the approximation error and stabilize the whole system. The design procedure of the proposed controller is constructed according to the backstepping control technique so that the stability of the closed‐loop system is guaranteed based on Lyapunov criteria. The proposed method is then tested on a simulated vessel system using computer simulation and compared with other state‐of‐the‐art methods. The comparison results demonstrate the superior performance of the proposed approach.
A variance‐constrained approach to event‐triggered distributed extended Kalman filtering with multiple fading measurements
Authors: Song Weihao , Wang Jianan , Wang Chunyan , Shan Jiayuan 
Published: January 2019

SummaryIn this paper, a distributed extended Kalman filtering problem is studied for discrete‐time nonlinear systems with multiple fading measurements. To alleviate the network communication burden, the event‐triggered communication scheme is employed in both sensor‐to‐estimator channel and estimator‐to‐estimator channel. As such, the data transmission is executed only when the predefined event occurs. In addition, a set of independent random variables with known statistical properties is defined to represent the phenomenon of multiple fading measurements. The variance‐constrained approach is adopted to derive an upper bound for the estimation error covariance in consideration of the event‐triggered mechanism and truncated error by linearization. The filter gain for each node is then designed to minimize such an upper bound by recursively solving two Raccati‐like difference equations. By virtue of the stochastic stability theory, a sufficient condition is provided to guarantee the boundedness of the estimation error. Finally, a simulation example is presented to illustrate the feasibility and effectiveness of the proposed filtering algorithm.
Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma Angiogenesis
Authors: Boyd Nathaniel H. , Walker Kiera , Ayokanmbi Adetokunbo , Gordon Emily R. , Whetsel Julia , Smith Cynthia M. , Sanchez Richard G. , Lubin Farah D. , Chakraborty Asmi , Tran Anh Nhat , Herting Cameron , Hambardzumyan Dolores , Yancey Gillespie G. , Hackney James R. , Cooper Sara J. , Jiao Kai , Hjelmeland Anita B. 
Published: January 2019

AbstractTumorigenic and non-neoplastic tissue injury occurs via the ischemic microenvironment defined by low oxygen, pH, and nutrients due to blood supply malfunction. Ischemic conditions exist within regions of pseudopalisading necrosis, a pathological hallmark of glioblastoma (GBM), the most common primary malignant brain tumor in adults. To recapitulate the physiologic microenvironment found in GBM tumors and tissue injury, we developed an in vitro ischemic model and identified chromodomain helicase DNA-binding protein 7 (CHD7) as a novel ischemia-regulated gene. Point mutations in the CHD7 gene are causal in CHARGE syndrome (a developmental disorder causing coloboma, heart defects, atresia choanae, retardation of growth, and genital and ear anomalies) and interrupt the epigenetic functions of CHD7 in regulating neural stem cell maintenance and development. Using our ischemic system, we observed microenvironment-mediated decreases in CHD7 expression in brain tumor-initiating cells and neural stem cells. Validating our approach, CHD7 was suppressed in the perinecrotic niche of GBM patient and xenograft sections, and an interrogation of patient gene expression datasets determined correlations of low CHD7 with increasing glioma grade and worse patient outcomes. Segregation of GBM by molecular subtype revealed a novel observation that CHD7 expression is elevated in proneural versus mesenchymal GBM. Genetic targeting of CHD7 and subsequent gene ontology analysis of RNA sequencing data indicated angiogenesis as a primary biological function affected by CHD7 expression changes. We validated this finding in tube-formation assays and vessel formation in orthotopic GBM models. Together, our data provide further understanding of molecular responses to ischemia and a novel function of CHD7 in regulating angiogenesis in both neoplastic and non-neoplastic systems. Stem Cells 2019;37:453–462
Behavioral Response of Juvenile Chinook Salmon to Surgical Implantation of Micro‐acoustic Transmitters
Authors: Singer Gabriel P. , Hansen Matthew J. , Ho Kristina V. , Lee Katie W. , Cocherell Dennis E. , Peter Klimley A. , Rypel Andrew L. , Fangue Nann A. 
Published: January 2019

AbstractAcoustic telemetry, a commonly used tool for examining movements and survival of aquatic species, is often applied without a comprehensive understanding of transmitter implantation effects. This can be problematic when the goal of the study is to use telemetry results to make inferences regarding broader populations. Here, we examined juvenile Chinook Salmon Oncorhynchus tshawytscha at varying time intervals after transmitter implantation to assess the behavioral implications of tagging. The following behavioral metrics in response to a novel environment were compared across treatment and control groups: time to emergence from shelter into the open portion of the test arena, rheotactic response, total activity, and rates of exploration. Tagged fish (114–132 mm FL) were tested at 0, 1, or 4 d postsurgery (day‐0, day‐1, and day‐4 groups, respectively), and their behavior was compared to that of similarly handled control fish. Emergence from refuge was the only metric that differed significantly between treatment and control groups. Fish tested on the same day as the surgery were less likely to emerge from the refuge, with only 46% of the day‐0 tagged fish emerging compared to 88, 93, and 80% of the day‐1, day‐4, and control groups, respectively. However, day‐0 fish that did emerge from the refuge had rheotactic responses, total activity, and exploration rates similar to those of fish from the other treatment and control groups. This study may have fisheries research and management implications, especially for telemetry studies and monitoring efforts. We encourage researchers using this technology to consider (1) observing a post‐transmitter‐implantation recovery period of at least 24 h prior to release, adjusting study plans and logistics accordingly; (2) applying sufficient scientific rigor to emerging tagging technology prior to wide‐scale adoption; and (3) when possible, conducting concurrent battery life and tag effects studies with any field release of tagged fishes, as differing relationships between fish size, tag size, and tagging techniques may yield variable results.
Construction of Finsler‐Lyapunov functions with meshless collocation
Authors: Giesl Peter 
Published: January 2019

AbstractWe study the stability of invariant sets such as equilibria or periodic orbits of a Dynamical System given by a general autonomous nonlinear ordinary differential equation (ODE). A classical tool to analyse the stability are Lyapunov functions, i.e. scalar‐valued functions, which decrease along solutions of the ODE. An alternative to Lyapunov functions is contraction analysis. Here, stability (or incremental stability) is a consequence of the contraction property between two adjacent solutions, formulated as the local property of a Finsler‐Lyapunov function. This has the advantage that the invariant set plays no special role and does not need to be known a priori.In this paper, we propose a method to numerically construct a Finsler‐Lyapunov function by solving a first‐order partial differential equation using meshless collocation. Depending on the expected attractor, the contraction only takes place in certain directions, which can easily be implemented within the method. In the basin of attraction of an exponentially stable equilibrium or periodic orbit, we show that the PDE problem has a solution, which provides error estimates for the numerical method. Furthermore, we show how the method can also be applied outside the basin of attraction and can detect the stability as well as the stable/unstable directions of equilibria. The method is illustrated with several examples.