bluuebunny/crossref_metadata_2025_split huggingface dataset:
Moving towards novel multidisciplinary approaches for improving elderly quality of life: The emerging role of telemedicine in Sicily
Authors: Maresca Giuseppa , De Cola Maria C , Caliri Santina , De Luca Rosaria , Manuli Alfredo , Scarcella Ileana , Silvestri Giuseppe , Bramanti Placido , Torrisi Michele , Calabrò Rocco S , Bramanti Alessia ,   the Sicilian Teleneurology Group
Published: February 2018

Introduction Elderly care is a worldwide social and economic challenge for the public health system, and it requires the development of new management strategies. Telemedicine provides an innovative approach towards elderly care, especially for those with chronic diseases. In this study, we aimed to evaluate the potential role of a multidisciplinary telemedicine approach for improving elderly quality of life. Methods Twenty-two participants received weekly vital parameter monitoring and nutritional counselling, biweekly psychological counselling and a monthly consultation with a neurologist. The neuropsychological assessment included the Mini Mental State Examination, the Activities of Daily Living, the Instrumental Activities of Daily Living, the Geriatric Depression Scale and the Short-Form Health Survey, and was administered at enrolment (T0) and at the end of the study (T3). The nutritional evaluation included haematochemical examinations of glycaemia, total cholesterol, and triglycerides at baseline (T0) and every four months (T1, T2, T3). Results Significant differences in Activities of Daily Living, Geriatric Depression Scale and all domains of the Short-Form Health Survey were observed between baseline and the end of the study. The haematochemical parameters showed obvious changes over time, especially in cholesterol values, and the patients with hypercholesterolaemia and hypertriglyceridaemia showed a reduction in body mass index. Moreover, we found that the haematochemical values were moderately correlated with the Activities of Daily Living, Geriatric Depression Scale and Short-Form Health Survey scores. Conclusion Telemedicine can be a suitable tool for caring for elderly people more efficiently by promoting the remission of depressive symptoms and improving social functioning, cognitive levels and nutritional habits to prevent vascular diseases and exacerbations of pre-existing chronic illness.
A new selection method to increase the health benefits of CVD prevention strategies
Authors: Lagerweij Ghizelda R , de Wit G Ardine , Moons Karel GM , van der Schouw Yvonne T , Verschuren WM Monique , Dorresteijn Jannick AN , Koffijberg Hendrik ,   the CREW consortium
Published: February 2018

AbstractBackgroundCardiovascular disease (CVD) prevention is commonly focused on providing individuals at high predicted CVD risk with preventive medication. Whereas CVD risk increases rapidly with age, current risk-based selection of individuals mainly targets the elderly. However, the lifelong (preventable) consequences of CVD events may be larger in younger individuals. The purpose of this paper is to investigate if health benefits from preventive treatment may increase when the selection strategy is further optimised.MethodsData from three Dutch cohorts were combined (n = 47469, men:women 1:1.92) and classified into subgroups based on age and gender. The Framingham global risk score was used to estimate 10-year CVD risk. The associated lifelong burden of CVD events according to this 10-year CVD risk was expressed as quality-adjusted life years lost. Based on this approach, the additional health benefits from preventive treatment, reducing this 10-year CVD risk, from selecting individuals based on their expected CVD burden rather than their expected CVD risk were estimated. These benefits were expressed as quality-adjusted life years gained over lifetime.ResultsWhen using the current selection strategy (10% risk threshold), 32% of the individuals were selected for preventive treatment. When the same proportion was selected based on burden, more younger and fewer older individuals would receive treatment. Across all individuals, the gain in quality-adjusted life years was 217 between the two strategies, over a 10-year time horizon. In addition, when combining the strategies 5% extra eligible individuals were selected resulting in a gain of 628 quality-adjusted life years.ConclusionImprovement of the selection approach of individuals can help to reduce further the CVD burden. Selecting individuals for preventive treatment based on their expected CVD burden will provide more younger and fewer older individuals with treatment, and will reduce the overall CVD burden.
The effect of a medication reconciliation program in two intensive care units in the Netherlands: a prospective intervention study with a before and after design
Authors: Bosma Liesbeth B. E. , Hunfeld Nicole G. M. , Quax Rogier A. M. , Meuwese Edmé , Melief Piet H. G. J. , van Bommel Jasper , Tan SiokSwan , van Kranenburg Maaike J. , van den Bemt Patricia M. L. A. 
Published: February 2018

Abstract
Background
Medication errors occur frequently in the intensive care unit (ICU) and during care transitions. Chronic medication is often temporarily stopped at the ICU. Unfortunately, when the patient improves, the restart of this medication is easily forgotten. Moreover, temporal ICU medication is often unintentionally continued after ICU discharge. Medication reconciliation could be useful to prevent such errors. Therefore, the aim of this study was to determine the effect of medication reconciliation at the ICU.

Methods
This prospective 8-month study with a pre- and post-design was carried out in two ICU settings in the Netherlands. Patients were included when they used ≥ 1 chronic medicine and when the ICU stay exceeded 24 h. The intervention consisted of medication reconciliation by pharmacists at the moment of ICU admission and prior to ICU discharge. Medication transfer errors (MTEs) were collected and the severity of potential harm of these MTEs was measured, based on a potential adverse drug event score (pADE = 0; 0.01; 0.1; 0.4; 0.6). Primary outcome measures were the proportions of patients with ≥ 1 MTE at ICU admission and after discharge. Secondary outcome measures were the proportions of patients with a pADE score ≥ 0.01 due to these MTEs, the severity of the pADEs and the associated costs. Odds ratio and 95% confidence intervals were calculated, by using a multivariate logistic regression analysis.

Results
In the pre-intervention phase, 266 patients were included and 212 in the post-intervention phase. The proportion of patients with ≥ 1 MTE at ICU admission was reduced from 45.1 to 14.6% (ORadj 0.18 [95% CI 0.11–0.30]) and after discharge from 73.9 to 41.2% (ORadj 0.24 [95% CI 0.15–0.37]). The proportion of patients with a pADE ≥ 0.01 at ICU admission was reduced from 34.8 to 8.0% (ORadj 0.13 [95% CI 0.07–0.24]) and after discharge from 69.5 to 36.2% (ORadj 0.26 [95% CI 0.17–0.40]). The pADE reduction resulted in a potential net cost–benefit of € 103 per patient.

Conclusions
Medication reconciliation by pharmacists at ICU transfers is an effective safety intervention, leading to a significant decrease in the number of MTE and a cost-effective reduction in potential harm.
Trial registration Dutch trial register: NTR4159, 5 September 2013, retrospectively registered
Deep sustained response to daratumumab monotherapy associated with T-cell expansion in triple refractory myeloma
Authors: Usmani Saad Z. , Khan Imran , Chiu Christopher , Foureau David , Druhan Lawrence J. , Rigby Katherine , Casneuf Tineke , Sasser A. Kate 
Published: February 2018

Abstract
Background
Daratumumab, a human CD38 monoclonal antibody that has direct on-tumor and immunomodulatory mechanisms of action, demonstrated clinical benefit as monotherapy or in combination with established regimens in patients with multiple myeloma with one or more prior lines of therapy.

Case presentation
A male patient, who was 70 years of age at the time of diagnosis of multiple myeloma in 2011, relapsed after five lines of therapy, including autologous stem cell transplantation. The patient’s disease, which was considered high risk with a deletion of chromosome 17p, advanced quickly and was triple refractory 2 years after diagnosis leaving few treatment options. He was treated with daratumumab monotherapy in the SIRIUS clinical trial resulting in a stringent complete response and clearance of minimal residual disease. The duration of the patient’s clinical response is now over 3.5 years without relapse, compared with a median of 7.6 months for similarly treated patients. The patient’s immunophenotype revealed CD8+ T-cell expansion, clonal expansion of the T-cell receptor repertoire, and decreases in regulatory T cells during daratumumab therapy, suggesting a robust adaptive immune response. This immune response was still present 32 months into daratumumab therapy.

Conclusions
The results from this case report showed that a patient with advanced multiple myeloma, who had exhausted all treatment options with existing regimens, mounted an ongoing, deep, and durable response to daratumumab monotherapy. Further investigation of the immunologic profile provided additional patient-level evidence of an immunomodulatory mechanism of action of daratumumab.
Trial registration ClinicalTrials.gov Identifier number NCT01985126. Submitted 22 July 2013
Long-term outcomes of trauma-focused treatment in psychosis
Authors: van den Berg David , de Bont Paul A. J. M. , van der Vleugel Berber M. , de Roos Carlijn , de Jongh Ad , van Minnen Agnes , van der Gaag Mark 
Published: February 2018

SummaryWe present 12-month follow-up results for a randomised controlled trial of prolonged exposure and eye movement desensitisation and reprocessing (EMDR) therapy in 85 (78.8%) participants with psychotic disorder and comorbid post-traumatic stress disorder (PTSD). Positive effects on clinician-rated PTSD, self-rated PTSD, depression, paranoid-referential thinking and remission from schizophrenia were maintained up to 12-month follow-up. Negative post-traumatic cognitions declined in prolonged exposure and were stable in EMDR. A significant decline in social functioning was found, whereas reductions in interference of PTSD symptoms with social functioning were maintained. These results support that current PTSD guidelines apply to individuals with psychosis.Declaration of interestM.v.d.G. and D.v.d.B. receive income for published books on psychotic disorders and for the training of postdoctoral professionals in the treatment of psychotic disorders. A.d.J. receives income for published books on EMDR therapy and for the training of postdoctoral professionals in this method. A.v.M. receives income for published book chapters on PTSD and for the training of postdoctoral professionals in prolonged exposure. C.d.R. receives income for the training of postdoctoral professionals in EMDR therapy.
Retinoblastoma in Sub-Saharan Africa: Case Studies of the Republic of Côte d’Ivoire and the Democratic Republic of the Congo
Authors: Lukamba Robert M. , Yao Jean-Jacques A. , Kabesha Theophile A. , Budiongo Aleine N. , Monga Ben B. , Mwembo Albert T. , Bey Pierre , Chenge Gabrielle B. , Desjardins Laurence , Luboya Oscar N. , Doz François , Stefan Cristina D. 
Published: February 2018

Purpose In most low-income countries, the diagnosis of retinoblastoma is delayed, resulting in a severe prognosis. The objectives of this study were to describe the access to diagnosis and care of children diagnosed with retinoblastoma and the challenges in two sub-Saharan African countries: the Republic of Côte d’Ivoire and the Democratic Republic of the Congo. Patients and Methods A descriptive cross-sectional study was conducted. Data were collected from the medical records of patients admitted during the period of January 1, 2013 to December 31, 2014. Data were entered and analyzed using Epi Info7.1 software and SAS 9.3. Results One hundred sixteen cases of retinoblastoma were collected, including 60 boys and 56 girls. The median diagnosis age was 3 years for both countries. Ninety-eight patients (84%) had unilateral retinoblastoma. Most of the patients presented with advanced disease (76% had extraocular retinoblastoma). Median time between initial symptoms and diagnosis was 8.5 months (range, 0.4 to 116.7 months). Median time between diagnosis and treatment initiation was 31 days (range, 0 to 751 days). The median cost for the treatment of the disease was estimated at $1,954 per patient. Conclusion Late diagnosis of retinoblastoma, with extraocular disease, occurs frequently in both African countries. It is associated with delay in initiating treatment, and the cost of the treatment remains unaffordable for most of the families. Support groups for parents of affected children and the support of the Franco-African Pediatric Oncology Group remain important in improving early diagnosis and providing treatment in sub-Saharan African countries.
Building Oncofertility Core Competency in Developing Countries: Experience From Egypt, Tunisia, Brazil, Peru, and Panama
Authors: Salama Mahmoud , Ataman Lauren , Taha Tamer , Azmy Osama , Braham Marouen , Douik Fatma , Khrouf Mohamed , Rodrigues Jhenifer Kliemchen , Reis Fernando M. , Sánchez Flor , Romero Sergio , Vega Mario , Woodruff Teresa K. 
Published: February 2018

Purpose Little is known about oncofertility practice in developing countries that usually suffer from a shortage of health services, especially those related to cancer care. Materials and Methods To learn more about oncofertility practice in developing countries, we generated a survey to explore the barriers and opportunities associated with oncofertility practice in five developing countries from Africa and Latin America within our Oncofertility Consortium Global Partners Network. Responses from Egypt, Tunisia, Brazil, Peru, and Panama were collected, reviewed, and discussed. Results Common barriers were identified by each country, including financial barriers (lack of insurance coverage and high out-of-pocket costs for patients), lack of awareness among providers and patients, cultural and religious constraints, and lack of funding to help to support oncofertility programs. Conclusion Despite barriers to care, many opportunities exist to grow the field of oncofertility in these five developing countries. It is important to continue to engage stakeholders in developing countries and use powerful networks in the United States and other developed countries to aid in the acceptance of oncofertility on a global level.
Improving student nurses' confidence in managing the acutely ill patient
Authors: Smith Joyce , Rushton Melanie 
Published: February 2018

Aim:the Acute Illness Management (AIM) course was introduced into NHS trusts across Greater Manchester in 2002/03 for registered nurses. In preparation for the transition from student to registered nurse, the AIM course was then included in the final year of the undergraduate nursing programme. The aim of this study was to evaluate the impact of the AIM course on student nurses' confidence in managing the acutely ill patient.Method:a quantitative approach was adopted. Ethical approval was granted by the Research and Ethics committee at the University of Salford.Results:a total of 192 student nurses attended the AIM course; 94% of the students completed a pre-course questionnaire and 100% completed the post-course questionnaire.Conclusion:the evidence suggests a significant increase in the student nurses' confidence in recognising, responding and managing an acutely ill patient following the one-day course.
Reviews DVD/Blu-ray
Authors: Frangos Constantine , Carr Kim , Jackson Jessica P. , Kmosko Leah Rae 
Published: February 2018

Abstract
The Confession (L’aveu, 1970) France/Italy Director Costa-Gavras Runtime 138 minutes
Blu-ray USA, 2015 Produced and distributed by The Criterion Collection (region A/1)
Woman of the Year (1942) USA Director George Stevens Runtime 114 minutes
Blu-ray USA, 2017 Distributed by The Criterion Collection (region A/1)
Nightcrawler (2014) USA Director Dan Gilroy Runtime 117 minutes
DVD USA, 2015 Distributed by Universal Studios Home Entertainment (region 1)
“Just a Boy Who Made Me Laugh Once”
Revolutionary Road (2008) USA Director Sam Mendes Runtime 119 minutes
DVD USA, 2009 Distributed by Paramount Home Entertainment (region 1)
The apple sorting site: A case of design of living things
Authors: Kleinert Johanna 
Published: February 2018

Abstract
This article describes the apple as a designed product, while the process of sorting apples is viewed as design: In this process, an unclear mix of apples is turned into categories of neatly describable homogeneous apples. The course of action of apple sorting in an automated site is described, where digital datasets of images of the fruit are analysed automatically and serve as the basis for categorizing the fruit into sorting groups. The aim is to determine the underlying values that shape the process of apple sorting, comparing the requirements of the EU marketing standards to the more differentiated and demanding sorting groups observable in practice. Sorting as a control step becomes necessary to assign the contingent fruit taken from the plant into precisely specified categories. The analysis of the visual appearance of the fruit leads to conclusions about their quality and economic value. Here, apple sorting is viewed as a case of the design of living things in order to investigate the values that guide human intervention in living organisms. Additionally, apple sorting is also a case of Food Design that shows how even the most ‘natural’ food products are designed.
Sense, substance, fruit: Examining poetic descriptions of how people experience fruits as input for design considerations
Authors: Lee Thomas 
Published: February 2018

Abstract
This article discusses the intimate sensory relations between humans and fruit. It articulates a view that the dynamically interrelated characteristics of microstructural complexity, sweetness and extreme malleability make the experiential dimensions of fruit distinctive in anthropological experience. The article draws on the work of Steven Connor for theoretical support. Particular focus is given to his concept of ‘senstance’, which emphasizes the important role substances have in the human imagination, and inversely, the way imagination allows humans to make explicit the seductive but often obscure properties of substances. It proposes Connor is a worthy inheritor of the place held by thinkers such as Roland Barthes and Gaston Bachelard, whose work has been an enduring influence for design theorists and historians. Fruit-focused examples from poetry, art and design are discussed with the view of elaborating a suitably rich and multifaceted account of the anthropological importance of this mundane but pervasive thing.
Book Reviews
Authors: Schifferstein Hendrik N. J. , Parham Susan , Carta Silvio , Parasecoli Fabio 
Published: February 2018

Abstract

Katja Gruijters Food Design: Exploring the Future of Food, Ed van Hinte (2016)
Houten, the Netherlands: Uitgeverij Terra, 216 pp.,
ISBN: 9789089896889, p/bk, €40

Food and Architecture: At the Table, Samantha L. Martin-McAuliffe (ed.) (2016)
London and New York: Bloomsbury Academic, 304 pp.,
ISBN: 9780857857347, p/bk, £24.99

Food Democracy: Critical Lessons in Food, Communication, Design and Art, Oliver Vodeb (ed.) (2017)
Bristol: Intellect, 500 pp.,
ISBN: 9781783207961, p/bk, £30
‘Doing–listening’ with Deranged’s Struck by a Murderous Siege: An  auto-ethnography of death metal vinyl consumption
Authors: Zenerian Eleftherios 
Published: February 2018

Abstract
This article deals with vinyl records from the perspective of the cultural study of everyday life. It focuses on the author’s rituals of vinyl consumption, using as a case study Deranged’s Struck by a Murderous Siege (2016). It is shown that in an era of media convergence listening to vinyl records is an activity in which a variety of media participate in ‘doing–listening’, a process that involves the invocation of a unique secret knowledge developed over social relationships with people and things, and memories of past experiences, through which the intertextual nature of death metal texts is revealed and the doer–listener produces his or her own culture. In that sense, the value of vinyl records cannot be estimated in advance, based on ‘objective’ attributes – such as size of artwork, distinctiveness of sound, aura attribution or feelings of technostalgia – but, instead, accrues through the process of co-production through doing–listening with texts.
From the ‘Patio’ to the ‘Agency’: The emergence and structuring of metal music in revolutionary Cuba
Authors: Varas-Díaz Nelson , González-Sepúlveda Osvaldo , Rivera Amador Andrés 
Published: February 2018

Abstract
Rock and metal music have a long and problematic history in Cuba. Considered counter-revolutionary during the 1960s, rock would raise eyebrows in Cuba. Later during the 1980s, metal music would be even more concerning for the local government. Both would be considered an affront to the revolutionary ‘New Man’. Still, the Island has the strongest metal scene in the Caribbean. How could this happen? This article aims to familiarize readers with how Cuba’s metal went from being an organic community-based endeavour to a State-sponsored entity and to discuss some of its potential tensions. In order to achieve this aim, we report data from our ethnographic observation and ten in-depth qualitative interviews with fans, musicians, scholars and culture-related government officials. We discuss the emergence of ‘María’s Patio’ as an organic metal community and highlight its role in Cuba. Furthermore, we discuss how this process led to the emergence of the State-sponsored Cuban Rock Agency and its potential tensions moving forward.
Tech noir: Aesthetic connections between Burroughs’ Naked Lunch and contemporary extreme metal
Authors: Mackenzie James Alexander 
Published: February 2018

Abstract
William S. Burroughs remains a shadowy presence in the history of metal music. But the connections that have been forged between the author and metal generally relate to the influence he has had upon the lexicon and themes of the genre. This article moves away from the issue of influence and argues that Burroughs’ radical literary style is analogous to contemporary extreme metal genres such as mathcore, which blend metal and punk. Both mathcore and Burroughs’ Naked Lunch employ structural unpredictability and rapid shifts in pace. But rather than simply disrupting the social order, these startling aesthetic strategies can be understood as representations of the contemporary world, which can encourage audiences to adapt to and retain agency within the chaos of postmodernity. The first steps are also taken in this article to assemble a genealogy of works that produce such empowering effects.