bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing hemorrhagic fever with renal syndrome in Hubei Province, China: a space–time cube-based approach
Authors: Zhao Youlin , Ge Liang , Liu Junwei , Liu Honghui , Yu Lei , Wang Ning , Zhou Yijun , Ding Xu 
Published: May 2019

Objective Hemorrhagic fever with renal syndrome (HFRS), a natural–focal infectious disease caused by hantaviruses, resulted in 37 deaths between 2011 and 2015 in Hubei Province, China. HFRS outbreaks are seasonally distributed, exhibiting heterogeneity in space and time. We aimed to identify the spatial and temporal characteristics of HFRS epidemics and their probable influencing factors. Methods We used the space–time cube (STC) method to investigate HFRS epidemics in different space–time locations. STC can be used to visualize the trajectories of moving objects (or changing tendencies) in space and time in three dimensions. We applied space–time statistical methods, including space–time hot spot and space–time local outlier analyses, based on a calculated STC model of HFRS cases, to identify spatial and temporal hotspots and outlier distributions. We used the space–time gravity center method to reveal associations between possible factors and HFRS epidemics. Results In this research, HFRS cases for each space–time location were defined by the STC model, which can present the dynamic characteristics of HFRS epidemics. The STC model delivered accurate and detailed results for the spatiotemporal patterns of HFRS epidemics. Conclusion The methods in this paper can potentially be applied for infectious diseases with similar spatial and temporal patterns.
Survivorship and Outcome of Hip Arthroscopy for Femoroacetabular Impingement Syndrome Performed With Modern Surgical Techniques
Authors: Nho Shane J. , Beck Edward C. , Nwachukwu Benedict U. , Cvetanovich Gregory L. , Neal William H. , Harris Joshua D. , Weber Alexander E. , Mather Richard C. 
Published: May 2019

Background: Hip arthroscopy for femoroacetabular impingement syndrome (FAIS) is a rapidly growing field in sports surgery; however, factors associated with poor outcomes and identification of predictor models of inferior clinical outcomes is unclear. Purpose: To analyze predictors of clinical failure and inferior clinical outcomes among patients undergoing hip arthroscopy for treatment of FAIS. Study Design: Case-control study; Level of evidence, 3. Methods: Data were collected and analyzed from consecutive patients who underwent primary hip arthroscopy with routine capsular closure for the treatment of FAIS from a single fellowship-trained surgeon between January 2012 and November 2015. Baseline data, postoperative patient-reported outcomes, and rates of clinical failure and inferior clinical outcomes were recorded at 2 years postoperatively. Clinical failure was defined by revision hip arthroscopy or conversion to total hip arthroplasty. Inferior clinical outcome was defined as not reaching the minimal clinically important difference (MCID) or patient acceptable symptomatic state for Hip Outcome Score–Activities of Daily Living. A multivariate logistic regression analysis was used to identify significant predictors of clinical failure and inferior clinical outcome. Results: Out of 1161 eligible patients, 935 (80.5%) completed 2-year postoperative patient-reported outcomes. The mean ± SD age and body mass index were 33.3 ± 12.3 years and 25.4 ± 8.2 kg/m2, respectively. The overall clinical failure rate was 3.6% (n = 34), including 23 cases (2.5%) of revision hip arthroscopy and 11 cases (1.2%) of conversion to total hip arthroplasty. Predictors of clinical failure were lower preoperative International Hip Outcome Tool score ( P = .016), chronic preoperative pain ( P = .001), and chondromalacia in the affected hip ( P = .04). The inferior clinical outcome group, consisting of those who failed to reach the MCID for Hip Outcome Score–Activities of Daily Living, included 256 patients (27.4%). Predictors of inferior clinical outcomes were Tönnis grade >1 ( P = .01), workers’ compensation ( P < .001), and increased body mass index ( P = .02). Conclusion: This study demonstrates that 73% of all patients treated for symptomatic FAIS with primary hip arthroscopy and routine capsular closure achieved the MCID. Clinical failure is predicted by a number of modifiable and nonmodifiable factors, including chronic preoperative pain and presence of chondromalacia. The current study updates the midterm failure rates and outcomes achievable with hip arthroscopy for FAIS.
The Experiences and Support Needs of Grandparents of Children Born With Cleft Lip and/or Palate
Authors: Guest Ella , Costa Bruna , McCarthy Gillian , Cunniffe Claire , Stock Nicola Marie 
Published: May 2019

Objective: The birth of a child with a cleft lip and/or palate (CL/P) can have a significant emotional and social impact on parents. Yet, the impact on the wider family is rarely investigated. Grandparents are becoming increasingly involved in the care of their grandchildren and may therefore have support needs of their own. The aim of the current study was to explore the experiences and support needs of grandparents of children born with CL/P. Design: Individual semistructured telephone interviews were carried out with 12 grandparents of children born with CL/P and were analyzed using inductive thematic analysis. Results: Five themes were identified (1) emotional impact of CL/P on grandparents, (2) grandparents’ social experiences, (3) grandparents’ involvement, (4) grandparents’ information needs, and (5) grandparents’ support needs. Participants experienced difficult emotions around the time of diagnosis and were concerned about the child’s treatment and future experiences. Participants played a significant role in supporting the whole family, but received little information or support themselves. Conclusions: Grandparents reported experiences comparable to published literature on parents. Clinicians and charitable organizations could consider how existing resources could be made more accessible to and/or adapted for wider family members, including grandparents.
Impact of alemtuzumab on health-related quality of life over 6 years in CARE-MS II trial extension patients with relapsing-remitting multiple sclerosis
Authors: Arroyo Rafael , Bury Denise P , Guo Jennifer D , Margolin David H , Melanson Maria , Daizadeh Nadia , Cella David 
Published: May 2019

Background: In CARE-MS II (Comparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis; NCT00548405), alemtuzumab (12 mg/day; baseline: 5 days; 12 months later: 3 days) significantly improved health-related quality of life (HRQL) outcomes versus subcutaneous interferon beta-1a (SC IFNB-1a) in relapsing-remitting multiple sclerosis (RRMS) patients over 2 years. Patients completing CARE-MS II could enter a 4-year extension study (NCT00930553). Objective: The aim of this study is to assess 6-year HRQL outcomes in alemtuzumab-treated CARE-MS II patients, including those with highly active disease (HAD). Methods: During extension, patients could receive additional alemtuzumab for clinical/magnetic resonance imaging (MRI) activity or other disease-modifying therapies per investigator’s discretion. Assessments include Functional Assessment of Multiple Sclerosis (FAMS), 36-Item Short-Form Health Survey (SF-36), and EQ-5D visual analog scale (EQ-VAS). Results: Alemtuzumab-treated patients improved or stabilized all HRQL measures over 6 years with significant improvements from baseline at all time points on EQ-VAS and for up to 5 years on FAMS, SF-36 MCS, and SF-36 PCS. Alemtuzumab-treated patients with HAD showed significant improvements versus baseline at Year 2 on all HRQL measures, and significant improvements versus SC IFNB-1a on SF-36 PCS and EQ-VAS; however, the improvements did not reach the threshold for clinical relevance. Conclusion: Alemtuzumab-treated CARE-MS II patients improved or stabilized HRQL versus baseline over 6 years. This is the first study to show long-term HRQL benefits in patients with HAD.
Physiotherapy management of patients with major chest trauma: Results from a global survey
Authors: Aswegen Heleen van , Reeve Julie , Beach Lisa , Parker Romy , Olsèn Monika Fagevik 
Published: May 2019

Aim Major chest trauma is associated with significant morbidity and mortality. Management of patients with major chest trauma includes pain relief, ventilatory management, surgical fixation and early rehabilitation to improve both short- and long-term outcomes. Physiotherapy is widely considered an integral component of the multidisciplinary trauma team and aims to improve respiratory status and reduce the sequelae associated with immobility and reduced physical function. Despite this there is scarce evidence describing or investigating physiotherapy interventions and how these practices vary worldwide. The aim of this study was to ascertain the current physiotherapy management of patients having sustained major chest trauma and to investigate how such practices varied internationally. Methods A purpose designed online survey was administered to a group of experienced physiotherapists who work in the field of trauma. Results Response rate was 51% ( n = 49) and respondents represented all five continents. Respondents reported focussing on active coughing ( n = 46, 96%, r = 0.5, p = 0.98), body positioning ( n = 43, 94%, r = 0.7, p = 0.41), deep breathing exercises ( n = 44, 94%, r = 0.8, p = 0.66) and early mobilisation ( n = 47, 98%, r = 1, p = 0.64). Ambulation in hospital was reported to be common ( n = 46, 98%, r = 0.2, p = 0.99) but rehabilitation to address longer term sequelae following hospital discharge was reported to be rare ( n = 4, 8%). Conclusion This survey has highlighted those practices used by physiotherapists worldwide which aim to address the complications associated with major chest trauma. Having established global practice, the study provides a platform for future research investigating the efficacy of such interventions in improving both short- and long-term outcomes for patients following major chest injury.
Impact of the onset of fixed appliance therapy on adolescents’ quality of life using a specific condition questionnaire: A cross-sectional comparison between male and female individuals
Authors: Corradi-Dias Larissa , Paiva Saul Martins , Pretti Henrique , Pordeus Isabela Almeida , Abreu Lucas Guimarães 
Published: May 2019

Objective: To evaluate the impact of the first six months of orthodontic treatment with fixed appliances on the oral health-related quality of life (OHRQoL) of adolescents, comparing boys and girls, using a specific condition questionnaire. Design: Cross-sectional. Setting: School of Dentistry of the Federal University of Minas Gerais, Belo Horizonte, Brazil Participants: Adolescents aged 10–17 years. Methods: Forty-six adolescents participated in this study. Adolescents’ OHRQoL was evaluated using the Brazilian version of the questionnaire Impact of Fixed Appliances Measure. This questionnaire comprises 43 questions distributed across nine domains: aesthetics; functional limitation; dietary impact; oral hygiene impact; maintenance impact; physical impact; social impact; time constraints; and travel/cost/inconvenience implications. The answer options follow the Likert scale, in the range of 1–5. A higher score indicates a more negative impact on the OHRQoL. Adolescents’ malocclusion was assessed using the Dental Aesthetic Index. Information on family income, adolescents’ age and tooth extraction was also collected. A directed acyclic graph was used to identify potential confounders. Statistical analysis involved the chi-square test, the Student’s t test and the analysis of covariance. The minimal clinically important difference was also calculated. Results: Of the 46 participants, 25 were girls and 21 were boys. The female adolescents presented a more negative impact from the orthodontic treatment on the quality of life when compared to the male adolescents ( P < 0.001), regardless of the influence of the confounding variables. The most negative repercussions were identified in the domains of oral hygiene ( P = 0.002), physical impact ( P < 0.001) and social impact ( P < 0.001). Conclusion: The impact of the first six months of orthodontic treatment on OHRQoL is more negative in female individuals than in male individuals. The results of this study may be useful for the oral healthcare provider during the counselling of adolescents undergoing fixed appliance therapy.
Power, anxiety, and relationships between returning citizens and parole officers
Authors: Cnaan Ram A , Woida Kelsey 
Published: May 2019

Summary This study evaluates the relationships between parole officers and ex-prisoners, who return to communities after incarceration (returning citizens). We measured returning citizens’ anxiety about meeting their parole officers and the ways in which they prepare for their meetings. We relate anxiety levels to developing a therapeutic alliance, client confidence that their parole officer is working in their best interest, client truthfulness about their housing and work status, and client optimism about their reentry process. To measure returning citizen anxiety and experience with parole officers, we carried out a survey of returning citizens (N = 193) in Philadelphia just before they were to meet their parole officers. Findings The results illuminate the ways that anxiety has significant negative impact on the quality of the working relationship between returning citizens and their parole officers but not precautionary behaviors. Returning citizens who reported higher anxiety prior to meeting their parole officer tend to report lower therapeutic alliance, less confidence that the parole officer works on their behalf, and less truthfulness. Implications Our findings provide more insight into what needs and challenges people on parole and probation face and outline new ideas about which of these factors parole officers should attend to in order to improve the services they provide. We call for parole officers to be cognizant of the anxiety that people under probation face and the need to make them feel supported and at ease. We also call for social workers in most countries to take a more active role in the provision of parole and probation services.
Variability of Reporting Recurrence After Arthroscopic Bankart Repair: A Call for a Standardized Study Design
Authors: Kennedy Mitchell I. , Murphy Colin , Dornan Grant J. , Moatshe Gilbert , Chahla Jorge , LaPrade Robert F. , Provencher Matthew T. 
Published: May 2019

Background: High recurrence rates have been reported after anterior shoulder dislocations, regardless of the treatment utilized. However, the definition of recurrent instability has been inconsistent, making a comparison between studies difficult. Purpose: To report on the nature with which the rate of recurrent instability is reported after arthroscopic Bankart repair, across all levels of evidence, and to analyze factors that may affect the reported rate of recurrence. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review of the literature was performed by searching PubMed, the Cochrane Central Register of Controlled Trials, Embase, and ClinicalTrials.gov for studies published within the dates of January 2008 and September 2018. Studies in English that reported on the recurrence of instability after arthroscopic Bankart repair for anterior shoulder instability were considered for inclusion in this review. A meta-regression was performed to test for a linear association between the reported recurrence rate and several continuous covariates, including mean age at surgery, mean length of follow-up, attrition rate (loss to follow-up percentage), and percentage of male patients. Results: A trim-and-fill meta-analysis yielded an estimated overall recurrence rate of 17.4% (95% CI, 14.3%-20.9%). There was a significant difference in the recurrence rate depending on the level of evidence (Q(3) = 10.98; P = .012). Significant associations were found with the recurrence rate through the meta-regression, including a negative association with mean age ( P = .009), a positive association with mean follow-up time ( P = .002), and a positive association with attrition rate ( P = .035). Conclusion: A call for standardization is necessary for reporting outcomes of anterior instability after arthroscopic Bankart repair, especially with regard to the reporting of recurrence/failure rates, with careful consideration of the effects that may occur from patient demographics and study design. With no current recommendations for deeming failure, we suggest that all forms of instability be accounted for when determining a failed treatment procedure, with future studies placing an emphasis on greater control of the study design.
Outcomes of the Latarjet procedure for the treatment of chronic anterior shoulder instability: patients with prior arthroscopic Bankart repair versus primary cases
Authors: Werthel Jean-David , Sabatier Vincent , Amsallem Lior , Vigan Marie , Hardy Alexandre 
Published: May 2019

Objectives The two most common surgical interventions for recurrent anterior shoulder instability include arthroscopic Bankart repair and the Latarjet procedure. However, indications for each procedure remain debated between surgeons with 90% of surgeons (except French surgeons) preferring soft tissue Bankart repair initially. It remains unclear whether the results of a Latarjet procedure performed after a failed arthroscopic Bankart repair differ from those performed for primary cases. The purpose of our study was to compare the postoperative outcomes of patients who had undergone a Latarjet as a primary surgery versus those who had had a Latarjet as revision surgery for a failed arthroscopic Bankart repair Methods Patients who had undergone open or arthroscopic Latarjet procedure between 2003 and 2015 in 5 fellowship-trained surgical practices were included. Charts were retrospectively reviewed to identify patients who had undergone a primary Latarjet or those who had had a Bankart repair prior to the Latarjet. Age, ISIS score, BMI, sports activity, hyperlaxity and delay before surgery were retrospectively collected. Outcome measures were prospectively collected, including range of motion, SSV, Walch-Duplay, scores, recurrence of instability, apprehension or new surgery. Results A total of 311 patients were included. 28% of the patients were lost to follow-up and the mean follow-up was 3.4 years +/-0.8. There were 21 patients who had had a Bankart repair prior to the Latarjet procedure. Both populations were comparable regarding preoperative data. The postoperative instability rate was 3% in the overall population; 4.8% in the “primary Latarjet” group and 2.3% in the ”Latarjet for failed Bankart” group. This difference was not significant (p=0.50). However, the mean Walch-Duplay score was significantly lower and the pain scores significantly higher in patients who had had a prior Bankart repair: 51.9 +/- 25 versus 72.1 +/- 25.2 and 2.5/10 versus 1.2/10 respectively. The Simple Shoulder Test was comparable in both groups. Conclusion The study confirms that the Latarjet is an effective procedure to treat primary chronic anterior instability and also to stabilize a shoulder after a failed Bankart repair. However, the thought that a Bankart repair does not “burn any bridges” appears to be incorrect relative to postoperative pain and functional scores in the setting of future Latarjet procedure.
Birth and Growth of an Ultrasound Hand Surgery Center: a review of 1167 procedures
Authors: Croutzet Pierre , Guinand Regis , Djerbi Iskander 
Published: May 2019

Objectives With local anesthesia and new ultrasound-guided percutaneous procedures, it is now more often possible to perform hand surgery in minimal settings. Indeed, the authors argue that most hand surgery procedures could be performed in office surgeries. They have reported morbidities in a continuous series of 1167 ultrasound-assisted hand procedures performed under local anesthesia in a clinic setting. Methods Over a period of 3,5 years, 1167 in-office procedures (883 patients) were performed using specific ultrasound-guided techniques (previously published) under local anesthesia. We included 372 trigger fingers, 516 carpal tunnel releases, 28 de Quervain releases and 213 Dupuytren contractures, 7 lateral epicondylitis, 31 k-wire removal Exclusion criteria for office surgery were: - ASA (American Society of Anesthesiologists) grade 3 or higher - allergic history (latex, xylocaine…) - age over 85 Asepsis was achieved with a preoperative iodine shower and a 5-step antiseptic skin preparation.Fasting was forbidden and disease-modifying treatments, including anticoagulants, taken as usual. The WALANT technique was used for local anesthesia. All procedures were performed percutaneously under ultrasound guidance. Surgical blades were proscribed, only a 18 gauge needle was used for skin incision. All the instruments were thinner than 1.5 mm, non-disposable and cost less than 50 Bandages were removed by the patient. Bandages were removed by the patient the day after surgery. Morbidities were reported systematically: - before surgery, during local anesthesia (vagal faintness, panic attack) - during surgery (pain, excessive bleeding, faintness, mild heart attack) - after surgery (infection, Sudeck’s disease, hematoma, scarring problem) Individual procedure efficacy was assessed in previous studies and not included in this series. Results: Preoperative: - 21 vagal faintness, including 7 syncopes with spontaneous resolution (6 vagal faintness (with 3 syncopes) was observed in the last 1000 patients) - no panick attack Operative: - no pain felt - no excessive bleeding, no specific hemostasis procedure needed - no heart attack Postoperative: - 1 infection in a trigger finger requiring re-operation - 19 Sudeck’s disease - 10 mild hematoma after carpal tunnel release with spontaneous resolution Conclusion: The combination of the WALANT technique and ultrasound-assisted procedures provides an original approach that can be used in a clinic setting. The morbidities reported were at least equivalent to those published in standard operating theatre procedures; only one patient was re-operated (case of infection). Hand surgery can be performed in good conditions as in-office surgery using local anesthesia and ultrasound guidance.