bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomimetic Composite Scaffolds to Manipulate Stem Cells for Aiding Rheumatoid Arthritis Management
Authors: Zhao Yue , Wang Zhonghan , Jiang Yingnan , Liu Hou , Song Shanliang , Wang Chenyu , Li Zuhao , Yang Zhe , Liu He , Wang Jincheng , Yang Bai , Lin Quan 
Published: May 2019

AbstractStem cell transplantation is a promising alternative therapy for rheumatoid arthritis (RA) patients, with the potential to suppress autoimmune inﬂammation and prevent joint damage. However, widespread application of RA therapy based on stem cell transplantation is limited due to poor migration, local retention, and uncontrolled differentiation of stem cells. Here, inspired by the dynamic construction of bone matrix, a structurally and functionally optimized scaffold for loading bone marrow stem cells (BMSCs) is designed to aid RA management. The composite scaffolds consist of stiff 3D printing porous metal scaffolds (3DPMS) and soft multifunctional polysaccharide hydrogels, wherein 3DPMS meet the requirements for large‐scale bone defects caused by RA. Attractively, the fabricated hydrogels on the composite scaffold are self‐healable, injectable, biocompatible, and biodegradable, which endow the resultant scaffold many aspects mimicking the extracellular matrix (ECM). After encapsulation of BMSCs, hydrogels are administered into the inner pores of 3DPMS, abbreviated as BMSCs@3DPMS/hydrogels. In this study, BMSCs@3DPMS/hydrogels have a good effect on improving RA, such as remodeling of knee joint articular cartilage, inhibition of inﬂammatory cytokines, and promotion of subchondral bone regeneration. Besides RA, the innovative scaffolds may also serve as an ideal biomaterial for other bone regenerative therapies in various orthopedic diseases.
Coupled Whispering Gallery Mode Resonators via Template‐Assisted Assembly of Photoluminescent Microspheres
Authors: Smith Marcus J. , Zeng Qingji , Lafalce Evan , Yu Shengtao , Zhang Shuaidi , Vardeny Zeev Valy , Tsukruk Vladimir V. 
Published: May 2019

AbstractThis study reports a facile method for the assembly of large, array style, coupled dye‐doped microsphere resonators by template‐assisted, in which an aqueous suspension of colloidal microspheres assemble on a patterned template. By exploiting the high resolution of 3D (two‐photon) lithography derived templates, closely packed large arrays, hundreds to thousands of dimers with controlled gap spacing, only limited by the size of the substrate can be achieved. Dye‐doped emissive microspheres with Q‐factors >2.5 × 102 can be achieved and trapped into predetermined cavity positions, thereby controlling the distance between adjacent microspheres. This design allows to scale down dimer spacing from usual 400 nm for traditional photolithography to very small spacing of 50 nm. It is found that exciting individual microspheres in the ensemble shows intense optical cavity modes, whereas closely coupled pairs show controlled mode splitting. Coupling between photoluminescent microspheres is strongly influenced by the gap distance, with strong coupling, equating to normal mode splitting, arising as the gap distance is reduced below traditional sub‐micrometer scale. The coupled dimer assemblies are promising candidates for advancing the development of large‐area coupled nanophotonic structures, beyond the spatial resolution‐limited photolithographical derived arrays.
Portable Low‐Pressure Solar Steaming‐Collection Unisystem with Polypyrrole Origamis
Authors: Li Weigu , Li Zheng , Bertelsmann Karina , Fan Donglei Emma 
Published: May 2019

AbstractSolar steaming has emerged as a promising green technology that can address the global issue of scarcity of clean water. However, developing high‐performance, cost‐effective, and manufacturable solar‐steaming materials, and portable solar steaming‐collection systems for individuals remains a great challenge. Here, a one‐step, low‐cost, and mass‐producible synthesis of polypyrrole (PPy) origami‐based photothermal materials, and an original portable low‐pressure controlled solar steaming‐collection unisystem, offering synergetic high rates in both water evaporation and steam collection, are reported. Due to enhanced areas for vapor dissipation, the PPy origami improves the water evaporation rate by at least 71% to 2.12 kg m−2 h−1 from that of a planar structure and exhibits a solar–thermal energy conversion efficiency of 91.5% under 1 Sun. When further controlling the pressure to ≈0.17 atm in the steaming‐collection unisystem, the water collection rate improves by up to 52% systematically and dramatically. Although partial energy is utilized toward obtaining low‐pressure, evaluations show that the overall energy efficiency is improved remarkably in the low‐pressure system compared to that in ambient pressure. Furthermore, the device demonstrates effective decontamination of heavy metals, bacteria, and desalination. This work can inspire new paradigms toward developing high‐performance solar steaming technologies for individuals and households.
3D‐Printed Flexible Tactile Sensor Mimicking the Texture and Sensitivity of Human Skin
Authors: Wang Haihang , Yang Hongmei , Zhang Sheng , Zhang Li , Li Jiusheng , Zeng Xiangqiong 
Published: May 2019

AbstractThe development of 3D printing technology toward multifunction devices may affect various fields from intelligent systems and wearable electronic devices to energy storage and flexible light‐emitting devices. A new type of piezoresistive sensor is designed by mimicking the texture and sensitivity of human skin. It is fabricated by 3D printing with a new kind of ink that is composed of interconnected polydimethylsiloxane microspheres (MPs) with carbon nanotubes distributed on their surfaces. This structure gives an electronic skin fabricated from these sensors modulus similar to that of human skin; furthermore, it elastically deforms under external forces. The response of the electronic skin to shear forces is evaluated by simulating the touch behavior of human skin, and it is found that the tactile sensors are sensitive to applied shear forces. They demonstrate sensitivity as low as 2.08 kPa−1 at a pressure of just 0.12 kPa, with short response time (50 ms), high durability (over 8000 cycles), and flexibility.
Site‐ and Stereoselective Phosphoramidation of Carbohydrates Using a Chiral Catalyst and a Chiral Electrophile
Authors: Glazier Daniel A. , Schroeder John M. , Blaszczyk Stephanie A. , Tang Weiping 
Published: May 2019

AbstractCarbohydrates are the most prevalent class of naturally occurring biomolecules. They mediate cell signaling, bacterial virulence, and metabolism, among other functions. The site‐selective functionalization of carbohydrates has been a long‐standing problem in chemistry. Phosphoramidates are a particularly challenging functional group to install stereoselectively because of the chirality at the phosphorus center. As such, the site‐ and stereoselective phosphoramidation of carbohydrates has never been achieved. We have developed the first site‐ and stereoselective phosphoramidation reaction of carbohydrates using a chiral catalyst and a chiral electrophile. This method offers a convenient solution for the selective synthesis of phosphoramidated carbohydrate‐containing prodrugs and natural products.magnified image
Wideband Epsilon‐Near‐Zero Supercoupling Control through Substrate‐Integrated Impedance Surface
Authors: He Yijing , Li Yue , Zhou Ziheng , Li Hao , Hou Yuefeng , Liao Shaolin , Chen Pai‐Yen 
Published: May 2019

AbstractThe supercoupling phenomenon of electromagnetic wave through arbitrary shaped epsilon‐near‐zero (ENZ) material channels has attracted considerable attention recently, leading to numerous intriguing applications. It has been demonstrated that around the cutoff frequency of fundamental TE10 mode, waveguide behaves as the 2D homogenous ENZ material. However, for a given waveguide geometry, the ENZ operating bandwidth is inherently narrow and the center frequency is fixed. Here, a reconfigurable ENZ medium is proposed and experimentally demonstrated with a wideband‐tunable supercoupling effect by means of inserting a metasurface inside the waveguide, named as substrate‐integrated impedance surface (SIIS). With different insertion depth (which can be mechanically tuned) of SIIS, the ENZ supercoupling frequency can be precisely controlled. The proposed technique not only achieves wideband tuning of the ENZ supercoupling, especially to control the enhanced group delay of the electromagnetic waves, thereby offering a promising way toward for tunable slow‐light devices, such as light storage and processing components.
Proanthocyanidin Interferes with Intrinsic Antibiotic Resistance Mechanisms of Gram‐Negative Bacteria
Authors: Maisuria Vimal B. , Okshevsky Mira , Déziel Eric , Tufenkji Nathalie 
Published: May 2019

AbstractAntibiotic resistance is spreading at an alarming rate among pathogenic bacteria in both medicine and agriculture. Interfering with the intrinsic resistance mechanisms displayed by pathogenic bacteria has the potential to make antibiotics more effective and decrease the spread of acquired antibiotic resistance. Here, it is demonstrated that cranberry proanthocyanidin (cPAC) prevents the evolution of resistance to tetracycline in Escherichia coli and Pseudomonas aeruginosa, rescues antibiotic efficacy against antibiotic‐exposed cells, and represses biofilm formation. It is shown that cPAC has a potentiating effect, both in vitro and in vivo, on a broad range of antibiotic classes against pathogenic E. coli, Proteus mirabilis, and P. aeruginosa. Evidence that cPAC acts by repressing two antibiotic resistance mechanisms, selective membrane permeability and multidrug efflux pumps, is presented. Failure of cPAC to potentiate antibiotics against efflux pump‐defective mutants demonstrates that efflux interference is essential for potentiation. The use of cPAC to potentiate antibiotics and mitigate the development of resistance could improve treatment outcomes and help combat the growing threat of antibiotic resistance.
Polyoxometalate‐Derived Ultrasmall Pt2W/WO3 Heterostructure Outperforms Platinum for Large‐Current‐Density H2 Evolution
Authors: Peng Ye‐Wang , Shan Changsheng , Wang Hong‐Juan , Hong Lu‐Ying , Yao Shuang , Wu Rui‐Juan , Zhang Zhi‐Ming , Lu Tong‐Bu 
Published: May 2019

AbstractPlatinum (Pt)‐based catalysts with high Pt utilization efficiency for efficient H2 evolution are attracting extensive attention to meet the issues of energy exhaustion and environmental pollution. Herein, a one‐step electrochemical method is demonstrated to construct ultrafine heterostructure Pt2W/WO3 on reduced graphene oxide (RGO) by injecting multielectrons into the Preyssler anion [NaP5W30O110]14− to codeposit with anodic deliquescent Pt cations. The resulting Pt2W/WO3/RGO shows much higher performance than that of commercial Pt catalysts for large‐current‐density H2 evolution, which can deliver a large current density of 500 mA cm−2 with an overpotential of only 394 mV, much lower than that of 20% Pt/C (578 mV). Comparisons with control experiments and density functional theory (DFT) calculations both suggest that the much enhanced activity can be mainly attributed to the synergistic cooperation of different components to drive fast and continuous hydrogen desorption on Pt2W/WO3/RGO, while it could not run normally for 20% Pt/C under similar conditions due to the formation of huge bubbles on the electrode surface. The effective integration of high catalytic activity and hydrogen desorption ability into a single material can yield advanced materials for large‐current‐density H2 evolution with remarkable stability.
Incorporating Solvate and Solid Electrolytes for All‐Solid‐State Li2S Batteries with High Capacity and Long Cycle Life
Authors: Shin Minjeong , Gewirth Andrew A. 
Published: May 2019

AbstractThe development of all‐solid‐state lithium–sulfur batteries is hindered by the poor interfacial properties at solid electrolyte (SE)/electrode interfaces. The interface is modified by employing the highly concentrated solvate electrolyte, (MeCN)2−LiTFSI:TTE, as an interlayer material at the electrolyte/electrode interfaces. The incorporation of an interlayer significantly improves the cycling performance of solid‐state Li2S batteries compared to the bare counterpart, exhibiting a specific capacity of 760 mAh g−1 at cycle 100 (330 mAh g−1 for the bare cell). Electrochemical impedance spectroscopy shows that the interfacial resistance of the interlayer‐modified cell gradually decreases as a function of cycle number, while the impedance of the bare cell remains almost constant. Cross‐section scanning electron microscopy (SEM)/ energy dispersive X‐ray spectroscopy (EDS) measurements on the interlayer‐modified cell confirm the permeation of solvate into the cathode and the SE with electrochemical cycling, which is related to the decrease in cell impedance. In order to mimic the full permeation of the solvate across the entire cell, the solvate is directly mixed with the SE to form a “solvSEM” electrolyte. The hybrid Li2S cell using a solvSEM electrolyte exhibits superior cycling performance compared to the solid‐state cells, in terms of Li2S loading, Li2S utilization, and cycling stability. The improved performance is due to the favorable ionic contact at the battery interfaces.
Improving Preprocedure Time Out Compliance Using Remote Audiovisual Observation
Authors: Dobbie Mary , Fitzpatrick Maureen , Kent Martha , Wojtal O'Neill Mara 
Published: May 2019

ABSTRACTHealth care organization leaders can help prevent surgical errors by ensuring compliance with standardized preprocedure time outs that require the active participation and engagement of the entire surgical team. Some surgical department leaders have used remote video observation without audio to monitor compliance with the time out. After a sentinel event occurred, leaders at our large academic medical center initiated a quality improvement project to audit compliance with the standardized preprocedure time out. We used remote audiovisual observation to ensure that all members of the procedure team were adhering strictly to the elements of the preprocedure time out in all invasive procedure areas. Since the beginning of this remote auditing process, team member compliance with the standardized preprocedure time out has improved.
A data‐driven particle filter for terrain based navigation of sensor‐limited autonomous underwater vehicles
Authors: Melo José , Matos Aníbal 
Published: May 2019

AbstractIn this article a new Data‐Driven formulation of the Particle Filter framework is proposed. The new formulation is able to learn an approximate proposal distribution from previous data. By doing so, the need to explicitly model all the disturbances that might affect the system is relaxed. Such characteristics are particularly suited for Terrain Based Navigation for sensor‐limited AUVs, where typical scenarios often include non‐negligible sources of noise affecting the system, which are unknown and hard to model. Numerical results are presented that demonstrate the superior accuracy, robustness and efficiency of the proposed Data‐Driven approach.
Abnormal auditory mismatch fields are associated with communication impairment in both verbal and minimally verbal/nonverbal children who have autism spectrum disorder
Authors: Matsuzaki Junko , Kuschner Emily S. , Blaskey Lisa , Bloy Luke , Kim Mina , Ku Matthew , Edgar James Christopher , Embick David , Roberts Timothy P. L. 
Published: May 2019

AbstractAbnormal auditory discrimination neural processes, indexed by mismatch fields (MMFs) recorded by magnetoencephalography (MEG), have been reported in verbal children with ASD. Association with clinical measures indicates that delayed MMF components are associated with poorer language and communication performance. At present, little is known about neural correlates of language and communication skills in extremely language impaired (minimally‐verbal/non‐verbal) children who have ASD: ASD‐MVNV. It is hypothesized that MMF delays observed in language‐impaired but nonetheless verbal children with ASD will be exacerbated in ASD‐MVNV. The present study investigated this hypothesis, examining MMF responses bilaterally during an auditory oddball paradigm with vowel stimuli in ASD‐MVNV, in a verbal ASD cohort without cognitive impairment and in typically developing (TD) children. The verbal ASD cohort without cognitive impairment was split into those demonstrating considerable language impairment (CELF core language index <85; “ASD‐LI”) versus those with less or no language impairment (CELF CLI >85; “ASD‐V“). Eighty‐four participants (8‐12 years) were included in final analysis: ASD‐MVNV: n = 9, 9.67 ± 1.41 years, ASD: n = 48, (ASD‐V: n = 27, 10.55 ± 1.21 years, ASD‐LI: n = 21, 10.67 ± 1.20 years) and TD: n = 27, 10.14 ± 1.38 years. Delayed MMF latencies were found bilaterally in ASD‐MVNV compared to verbal ASD (both ASD‐V and ASD‐LI) and TD children. Delayed MMF responses were associated with diminished language and communication skills. Furthermore, whereas the TD children showed leftward lateralization of MMF amplitude, ASD‐MVNV and verbal ASD (ASD‐V and ASD‐LI) showed abnormal rightward lateralization. Findings suggest delayed auditory discrimination processes and abnormal rightward laterality as objective markers of language/communication skills in both verbal and MVNV children who have ASD. Autism Res 2019, 12: 1225–1235. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryBrain imaging showed abnormal auditory discrimination processes in minimally‐verbal/non‐verbal children (MVNV) who have autism spectrum disorder (ASD). Delays in auditory discrimination were associated with impaired language and communication skills. Findings suggest these auditory neural measures may be objective markers of language and communication skills in both verbal and, previously‐understudied, MVNV children who have ASD.
Predicting reamputation risk in patients undergoing lower extremity amputation due to the complications of peripheral artery disease and/or diabetes
Authors: Czerniecki J M , Thompson M L , Littman A J , Boyko E J , Landry G J , Henderson W G , Turner A P , Maynard C , Moore K P , Norvell D C 
Published: May 2019

Abstract

Background
Patients undergoing amputation of the lower extremity for the complications of peripheral artery disease and/or diabetes are at risk of treatment failure and the need for reamputation at a higher level. The aim of this study was to develop a patient-specific reamputation risk prediction model.

Methods
Patients with incident unilateral transmetatarsal, transtibial or transfemoral amputation between 2004 and 2014 secondary to diabetes and/or peripheral artery disease, and who survived 12 months after amputation, were identified using Veterans Health Administration databases. Procedure codes and natural language processing were used to define subsequent ipsilateral reamputation at the same or higher level. Stepdown logistic regression was used to develop the prediction model. It was then evaluated for calibration and discrimination by evaluating the goodness of fit, area under the receiver operating characteristic curve (AUC) and discrimination slope.

Results
Some 5260 patients were identified, of whom 1283 (24·4 per cent) underwent ipsilateral reamputation in the 12 months after initial amputation. Crude reamputation risks were 40·3, 25·9 and 9·7 per cent in the transmetatarsal, transtibial and transfemoral groups respectively. The final prediction model included 11 predictors (amputation level, sex, smoking, alcohol, rest pain, use of outpatient anticoagulants, diabetes, chronic obstructive pulmonary disease, white blood cell count, kidney failure and previous revascularization), along with four interaction terms. Evaluation of the prediction characteristics indicated good model calibration with goodness-of-fit testing, good discrimination (AUC 0·72) and a discrimination slope of 11·2 per cent.

Conclusion
A prediction model was developed to calculate individual risk of primary healing failure and the need for reamputation surgery at each amputation level. This model may assist clinical decision-making regarding amputation-level selection.
Comparative study of breast cancer with or without concomitant Paget disease: An analysis of the SEER database
Authors: Chen Shijing , Chen Huaquan , Yi Ying , Jiang Xuemei , Lei Hai , Luo Xue , Chen Yu , Liu Sha , Yuan Dan , Jia Xinjian , Li Junyan 
Published: May 2019

AbstractBackgroundMost mammary Paget disease (MPD) is associated with underlying in situ or invasive breast cancer. The objective of this study was to compare the clinicopathological characteristics and survival outcomes between breast cancer with Paget disease (PD) and breast cancer alone.MethodsFrom the Surveillance, Epidemiology, and End Results (SEER) database, 2000‐2015, of the US National Cancer Institute, we identified 1569 women who had PD with invasive ductal carcinoma (PD‐IDC) and 1489 women who had PD with ductal carcinoma in situ (PD‐DCIS). Independent demographic and clinicopathological variables as well as survival outcomes of these patients were compared to patients with the corresponding breast cancer without concomitant PD.ResultsPD‐IDC and PD‐DCIS both had worse survival outcomes and poorer tumor characteristics than the corresponding disease without PD. Contrary to in the breast cancer alone groups, in the breast cancer with PD groups, the HR status (P = 0.182 in PD‐IDC and P = 0.371 in PD‐DCIS), HER2 status (P = 0.788 in PD‐IDC and P = 0.643 in PD‐DCIS), and combined molecular subtype (P = 0.196 in PD‐IDC and P = 0.853 in PD‐DCIS) were not found to affect disease prognosis. After matching tumor characteristics and treatment approaches, PD‐IDC as well as PD‐DCIS exhibited no significant difference in disease prognosis with corresponding IDC and DCIS. Finally, by comparative analysis, a kind of PD‐DCIS (ICD‐O‐3 code 8543/3) showed many invasive behaviors (31.8% of 8543/3 patients had stage I‐III cancer) and was associated with worse survival outcomes than the other type of PD‐DCIS.ConclusionsBreast cancer with concomitant PD was associated with more aggressive tumor characteristics and worse survival outcomes. The HR status, HER2 status, and combined molecular subtype could not affect the prognosis of breast cancer with PD. Moreover, a portion of the PD‐DCIS cases were invasive breast cancer cases that required special treatment.
Infantile osteomyelitis of the fourth rib causing the occurrence of a lung abscess
Authors: Mori Sayo , Onoyama Sagano , Takimoto Tomoko , Morooka Yuya , Furuno Kenji 
Published: May 2019

AbstractInfantile osteomyelitis of the rib is rare but can be complicated by intrapleural pyogenic lesions. Even if findings suggest another infection focus, osteomyelitis should be considered if there are changes on radiographs. In addition, it can be prevented by maintaining the dermal barrier function through skin care.