bluuebunny/crossref_metadata_2025_split huggingface dataset:
An adaptive Bayesian inversion for upper-mantle structure using surface waves and scattered body waves
Authors: Eilon Zachary , Fischer Karen M , Dalton Colleen A 
Published: April 2018

SummaryWe present a methodology for 1-D imaging of upper-mantle structure using a Bayesian approach that incorporates a novel combination of seismic data types and an adaptive parametrization based on piecewise discontinuous splines. Our inversion algorithm lays the groundwork for improved seismic velocity models of the lithosphere and asthenosphere by harnessing the recent expansion of large seismic arrays and computational power alongside sophisticated data analysis. Careful processing of P- and S-wave arrivals isolates converted phases generated at velocity gradients between the mid-crust and 300 km depth. This data is allied with ambient noise and earthquake Rayleigh wave phase velocities to obtain detailed V S and V P velocity models. Synthetic tests demonstrate that converted phases are necessary to accurately constrain velocity gradients, and S–p phases are particularly important for resolving mantle structure, while surface waves are necessary for capturing absolute velocities. We apply the method to several stations in the northwest and north-central United States, finding that the imaged structure improves upon existing models by sharpening the vertical resolution of absolute velocity profiles, offering robust uncertainty estimates, and revealing mid-lithospheric velocity gradients indicative of thermochemical cratonic layering. This flexible method holds promise for increasingly detailed understanding of the upper mantle.
Captopril Attenuates Cardiovascular and Renal Disease in a Rat Model of Heart Failure With Preserved Ejection Fraction
Authors: Salah Eman M. , Bastacky Sheldon I. , Jackson Edwin K. , Tofovic Stevan P. 
Published: April 2018

Abstract:
Heart failure with preserved ejection fraction (HFpEF), a prevalent form of heart failure, is frequently accompanied by the metabolic syndrome and kidney disease. Because current treatment options of HFpEF are limited, evaluation of therapies in experimental models of HFpEF with the metabolic syndrome and kidney disease is needed. In this study, we evaluated the effects of captopril, furosemide, and their combination in aged, obese ZSF1 rats, an animal model of HFpEF with the metabolic syndrome and chronic kidney disease as comorbidities. Captopril (100 mg/kg), furosemide (50 mg/kg), or their combination was administered orally to obese ZSF1 rats aged 20 to 44 weeks. Untreated ZSF1 rats served as controls. After 24 weeks of treatment, captopril significantly lowered systemic blood pressure and attenuated HFpEF as evidenced by significantly reduced left ventricular end diastolic pressures (10.5 ± 1.4 vs. 4.9 ± 1.3 mm Hg in Control vs. Captopril, respectively) and significantly lower left ventricular relaxation time constants (28.1 ± 2.9 vs. 18.3 ± 3.1 ms in Control vs. Captopril, respectively). The captopril-induced improvement in left ventricular function was associated with reduced cardiac hypertrophy, ischemia, necrosis, and vasculitis. Captopril also increased renal blood flow and glomerular filtration rate, reduced renal vascular resistance and proteinuria, and improved renal histology (ie, reduced renal hypertrophy, glomerulosclerosis, and tubular atrophy/dilation). Furosemide alone provided little benefit; moreover, furosemide did not augment the therapeutic benefits of captopril. This study suggests that chronic administration of captopril, but not furosemide, could be beneficial in patients with HFpEF, particularly in those with comorbidities such as obesity, diabetes, and dyslipidemias.
The Impact of Pediatric Outpatient Parenteral Antibiotic Therapy Implementation at a Tertiary Children’s Hospital in the United Kingdom
Authors: Patel Sanjay , Burzio Valentina , Green Helen , Rees Sara , Tebruegge Marc , Jones Christine , Faust Saul N. 
Published: April 2018

Background:
Recent advances in outpatient parenteral antibiotic therapy (OPAT) have largely focused on adult practice, and there are few published data on the safety and effectiveness of pediatric OPAT (p-OPAT).

Methods:
During a 3-year period (2012 to 2015), data were prospectively collected on patients managed within the p-OPAT service at Southampton Children’s Hospital, a tertiary pediatric hospital in the South of England.

Results:
A total of 130 p-OPAT episodes were managed during this period. The most frequently managed pathologies were bone and joint infections (44.6%), followed by ear, nose and throat (10.7%), respiratory (10.0%) and central nervous system (10.0%) infections. The most frequently used antimicrobial agent was ceftriaxone (n = 103; 79.2%). For the majority of p-OPAT episodes, antimicrobials were delivered in prefilled syringes (n = 109; 83.8%); 24-hour infusions administered by elastomeric devices were used less commonly (n = 16; 12.3%). The median duration of p-OPAT treatment was 9.2 days (interquartile range: 7.6–19.0 days). With regard to patient outcomes, 113 (86.9%) p-OPAT episodes resulted in cure and 12 (9.2%) in improvement; treatment failure occurred in 5 (3.9%) episodes. Intravenous catheter–related complications were rare. A total of 1683 bed days were saved over the 3-year period.

Conclusions:
Our data suggest that p-OPAT is safe and effective, with the potential to offer considerable savings for the healthcare economy through reduced length of inpatient stay.
In Vivo Evaluation of Subacromial and Internal Impingement Risk in Asymptomatic Individuals
Authors: Coats-Thomas Margaret S. , Massimini Daniel F. , Warner Jon J.P. , Seitz Amee L. 
Published: April 2018

Objective
The study aim was to evaluate subacromial and internal impingement risk between shoulders (dominant/nondominant) during dynamic motion using subject-specific anatomy and precise in vivo kinematics.

Design
In a prospective cross-sectional study, nine subjects underwent bilateral magnetic resonance (N = 18 shoulders) and fluoroscopic imaging during elevation and external rotation at 90 degrees of abduction. Subject-specific bone models were created and distances from footprint to (a) acromion and (b) glenoid were measured to evaluate risk.

Results
Throughout elevation, subacromial impingement risk was greater in the dominant shoulder (P = 0.0178). Regardless of side, high subacromial impingement risk occurred at 30% (78 degrees), 50% (101 degrees), and 70% (57 degrees) of the elevation cycle (P < 0.0001). High subacromial impingement risk also occurred at 30% (94 degrees), 50% (120 degrees), and 70% (63 degrees) of the external rotation motion cycle (P < 0.0001). Throughout both motions, internal impingement risk was not observed; however, the footprint and glenoid were closest at 50% of the elevation (101 degrees) and external rotation (120 degrees) cycles (P < 0.0001).

Conclusions
During elevation, subacromial impingement risk is greatest at lower arm positions (30% cycle, 78 degrees) and is greater in the dominant shoulder. High subacromial impingement risk also occurs with external rotation (63–120 degrees). Internal impingement risk does not occur with maximal elevation (101 degrees) or external rotation at 90-degree abduction but is more closely approached with elevation.
Perspectives From Family Caregivers of Persons With Spinal Cord Injury in Hospital Versus Rehabilitation: A Pilot Study
Authors: Eberhard Brigitte , Knüppel Lauener Susanne , Mahrer Imhof Romy 
Published: April 2018

Abstract

Purpose
The study aims to assess differences in family preferences for involvement in the ongoing care of a hospitalized family member with spinal cord injury based on whether the patient was hospitalized for initial rehabilitation (Group R) or hospitalized to treat secondary complications (Group C).

Design
Explorative cross-sectional design.

Method
Family members rated the importance and experience of involvement on five subscales of the Patient Participation in Rehabilitation Questionnaire. Differences among the importance and experience scores between the groups were tested using the Mann–Whitney U test.

Findings
Group C scored the importance to be involved significantly higher than Group R (M = 3.17 vs. M = 4.04, p =.01). No other significant differences between groups were detected.

Conclusion
Family members of patients hospitalized for secondary complications want greater involvement in care compared to those hospitalized for rehabilitation.

Clinical Relevance
Results indicate the need for tailored interventions using a family-centered approach and ongoing needs assessment.
The 100 Most Cited Articles on Healthcare Simulation
Authors: Walsh Chloe , Lydon Sinéad , Byrne Dara , Madden Caoimhe , Fox Susan , O'Connor Paul 
Published: April 2018

Summary Statement
This article provides an overview and synthesis of the 100 most cited healthcare simulation publications to provide insight into the articles that have shaped current knowledge and practice. Searches of the Scopus and Web of Science databases were conducted in July 2017. Most articles were concerned with medical education and training (86%) and were most often published in surgical journals (33%). Manikins (20%), standardized patients (16%), inanimate part-task trainers (16%), fully simulated environments (17%), and virtual reality part-task trainers (14%) were the most commonly featured types of simulators. Healthcare simulation research has matured and grown during the preceding decades. There has been a move away from research questions focused on “does simulation work?” to an assessment of the conditions under which simulation is most effective. It is hoped that providing an overview of highly cited works will help identify topics for further research.
Optimal timing of initiation of thromboprophylaxis in spine trauma managed operatively: A nationwide propensity-matched analysis of trauma quality improvement program
Authors: Zeeshan Muhammad , Khan Muhammad , O’Keeffe Terence , Pollack Nina , Hamidi Mohammad , Kulvatunyou Narong , Sakran Joseph V. , Gries Lynn , Joseph Bellal 
Published: April 2018

BACKGROUND
Patients with spinal trauma are at high risk for venous thromboembolic events (VTE). Guidelines recommend prophylactic anticoagulation but they are unclear on timing of initiation of thromboprophylaxis. The aim of our study was to assess the impact of early versus late initiation of venous thromboprophylaxis in patients with spinal trauma who underwent operative intervention.

METHODS
We performed a 2-year (2013–2014) review of patients with isolated spine trauma (spine-Abbreviated Injury Scale score, ≥ 3 and no other injury in another body region with Abbreviated Injury Scale score, > 2) who underwent operative intervention and received thromboprophylaxis postoperatively. Patients were divided into two groups based on the timing of initiation of thromboprophylaxis: early(<48 hours) and late(≥48 hours), and were matched in a 1:1 ratio using propensity score matching for demographics, admission vitals, injury parameters, type of operative intervention, hospital course, and type of prophylaxis(low molecular weight heparin vs. unfractionated heparin). Outcomes were rates of deep vein thrombosis (DVT) and/or pulmonary embolism, red-cell transfusions, the rate of operative interventions for spinal cord decompression and mortality after initiation of thromboprophylaxis.

RESULTS
Nine thousand five hundred eighty-five patients underwent operative intervention and received anticoagulants, of which 3554 patients (early, 1,772; late, 1,772) were matched. Matched groups were similar in demographics, injury parameters, emergency department vitals, hospital length of stay, rates of inferior vena cava (IVC) filter placement and time to operative procedure. Patients who received thromboprophylaxis within 48 hours of operative intervention, unlike those who did not, were less likely to develop DVT (2.1% vs. 10.8%, p < 0. 01). However, the rate of pulmonary embolism was similar in both groups (p = 0.75). Additionally, there was no difference in postprophylaxis red cell transfusion requirements (p = 0.61), rate of postprophylaxis decompressive procedure on the spinal cord (p = 0.27), and mortality (p = 0.53).

CONCLUSION
Early VTE prophylaxis is associated with decreased rates of DVT in patients with operative spinal trauma without increasing the risk of bleeding and mortality. The VTE prophylaxis should be initiated within 48 hours of surgery to reduce the risk of DVT in this high-risk patient population.

LEVEL OF EVIDENCE
Therapeutic studies, level IV.
Health care utilization and the cost of posttraumatic acute respiratory distress syndrome care
Authors: Robles Anamaria J. , Kornblith Lucy Z. , Hendrickson Carolyn M. , Howard Benjamin M. , Conroy Amanda S. , Moazed Farzad , Calfee Carolyn S. , Cohen Mitchell J. , Callcut Rachael A. 
Published: April 2018

BACKGROUND
Posttraumatic acute respiratory distress syndrome (ARDS) is associated with prolonged mechanical ventilation and longer hospitalizations. The relationship between posttraumatic ARDS severity and financial burden has not been previously studied. We hypothesized that increasing ARDS severity is associated with incrementally higher health care costs.

METHODS
Adults arriving as the highest level of trauma activation were enrolled in an ongoing prospective cohort study. Patients who survived 6 hours or longer are included in the analysis. Blinded review of chest radiographs was performed by two independent physicians for any intubated patient with Pao
2:FIO2 ratio of 300 mmHg or lower during the first 8 days of admission. The severity of ARDS was classified by the Berlin criteria. Hospital charge data were used to perform standard costing analysis.

RESULTS
Acute respiratory distress syndrome occurred in 13% (203 of 1,586). The distribution of disease severity was 33% mild, 42% moderate, and 25% severe. Patients with ARDS were older (41 years vs. 35 years, p < 0.01), had higher median Injury Severity Score (30 vs. 10, p < 0.01), more chest injury (Abbreviated Injury Scale score, ≥ 3: 51% vs. 21%, p < 0.01), and blunt mechanisms (85% vs. 53%, p < 0.01). By ARDS severity, there was no significant difference in age, mechanism, or rate of traumatic brain injury. Increasing ARDS severity was associated with higher Injury Severity Score and higher mortality rates. Standardized total hospital charges were fourfold higher for patients who developed ARDS compared with those who did not develop ARDS (US $434,000 vs. US $96,000; p < 0.01). Furthermore, the daily hospital charges significantly increased across categories of worsening ARDS severity (mild, US $20,451; moderate, US $23,994; severe, US $33,316; p < 0.01).

CONCLUSION
The development of posttraumatic ARDS is associated with higher health care costs. Among trauma patients who develop ARDS, total hospital charges per day increase with worsening severity of disease. Prevention, early recognition, and treatment of ARDS after trauma are potentially important objectives for efforts to control health care costs in this population.

LEVEL OF EVIDENCE
Economic and value-based evaluations, level IV.
A non-cell autonomous actin redistribution enables isotropic retinal growth
Authors: Matejčić Marija , Salbreux Guillaume , Norden Caren 
Published: April 2018

AbstractTissue shape is often established early in development and needs to be scaled isotropically during growth. However, the cellular contributors and ways in which cells interact inside tissues to enable coordinated isotropic tissue scaling are not yet understood. Here, we follow cell and tissue shape changes in the zebrafish retinal neuroepithelium, which forms a cup with a smooth surface early in development and maintains this architecture as it grows. By combining 3D analysis and theory, we show that a global increase in cell height is necessary to maintain this tissue shape during growth. Timely cell height increase is governed by non-cell autonomous actin redistribution. Blocking actin redistribution and cell height increase perturbs isotropic scaling and leads to disturbed, folded tissue shape. Taken together, our data show how global changes in cell shape enable isotropic growth of the developing retinal neuroepithelium, a concept that could also apply to other systems.
Genetic analysis using parent-progeny relationship for wood quality traits in Norway spruce (Picea abies (L.) Karst.)
Authors: Zhou Linghua , Chen Zhiqiang , Lindqvist Sven-Olof , Olsson Lars , Grahn Thomas , Karlsson Bo , Wu Harry X. , Gil María Rosario García 
Published: April 2018

AbstractTwo-generations pedigree involving 524 plus trees and their open-pollinated (OP) progenies were jointly studied to estimate parent-progeny correlation and heritability. Three wood traits (wood density, MFA, and MOE) were determined by SilviS-can in one ramet per plus tree and 12 OP progenies. Three ramets per plus tree and 12 OP were also measured with two indirect methods, Pilodyn and Hitman. The overall correlation between OP-based breeding values and plus tree-based phenotypes was low to moderate for all traits. The correlations between the phenotypic values of the mother trees and the breeding values estimated on their half-sib pro-genies are low to moderate. Reasons for this may be experimental errors in progeny trials and lack of experimental design in archives, contributing to the parent and progeny correlation. The management practices in the archive may contribute more to such low correlation. Offspring progeny heritability estimates based on SilviScan measurements were higher than parent-offspring regression using one single ramet from the archive. Moreover, when three ramets were measured the parent-offspring regression heritability estimates were higher than those based solely on progeny data for the Pilodyn and Hitman on the standing trees. The standard error of the heritability estimates decreased with increasing progeny size.
Increased speech representation in older adults originates from early response in higher order auditory cortex
Authors: Brodbeck Christian , Presacco Alessandro , Anderson Samira , Simon Jonathan Z. 
Published: April 2018

1SummaryPrevious research has found that, paradoxically, while older adults have more difficulty comprehending speech in challenging circumstances than younger adults, their brain responses track the acoustic signal more robustly. Here we investigate this puzzle by using magnetoencephalography (MEG) source localization to determine the anatomical origin of this difference. Our results indicate that this robust tracking in older adults does not arise merely from having the same responses as younger adults but with larger amplitudes; instead they recruit additional regions, inferior to core auditory cortex, as part of an early response peak at ~ 30 ms relative to the acoustic signal.
Movement imitation via an abstract trajectory representation in dorsal premotor cortex
Authors: Wong Aaron L. , Jax Steven A. , Smith Louisa L. , Buxbaum Laurel J. , Krakauer John W. 
Published: April 2018

ABSTRACTHumans are particularly good at copying novel and meaningless gestures. The mechanistic and anatomical basis for this specialized imitation ability remains largely unknown. One idea is that imitation occurs by matching body configurations. Here we propose an alternative route to imitation that depends on a body-independent representation of the trajectory path of the end-effector. We studied a group of patients with strokes in the left frontoparietal cortices. We found that they were equally impaired at imitating movement trajectories using the ipsilesional limb (i.e., the non-paretic side) that were cued either by an actor using their whole arm or just by a cursor, suggesting that body configuration is not always critical for imitation and that a representation of abstract trajectory shape may suffice. In addition, imitation ability was uncorrelated to the ability to identify the trajectory shape, suggesting a dissociation between producing trajectory shapes and perceiving their paths. Finally, a lesion-symptom mapping analysis found that imitation deficits were associated with lesions in left dorsal premotor but not parietal cortex. Together, these findings suggest a novel body-independent route to imitation that relies on the ability to plan abstract movement trajectories within dorsal premotor cortex.Significance StatementThe ability to imitate is critical for rapidly learning to produce new gestures and actions, but how the brain translates observed movements into motor commands is poorly understood. Examining the ability of patients with strokes affecting the left hemisphere revealed that meaningless gestures can be imitated by succinctly representing only the motion of the hand in space, rather than the posture of the entire arm. Moreover, performance deficits correlated with lesions in dorsal premotor cortex, an area not previously associated with impaired imitation of arm postures. These findings thus describe a novel route to imitation that may also be impaired in some patients with apraxia.
Wind tunnel tests of the inverted joined wing and a comparison with CFD results
Authors: Galinski Cezary , Krysztofiak Grzegorz , Miller Marek , Ruchala Pawel , Kalski Marek , Lis Mateusz , Dziubinski Adam , Bogdanski Krzysztof , Stefanek Lukasz , Hajduk Jaroslaw 
Published: April 2018

Purpose
The purpose of this paper is to present the methodology and approach adapted to conduct a wind tunnel experiment on the inverted joined-wing airplane flying model together with the results obtained.

Design/methodology/approach
General assumptions underlying the dual-use model design are presented in this paper. The model was supposed to be used for both wind tunnel tests and flight tests that significantly drive its size and internal structure. Wind tunnel tests results compared with the outcome of computational fluid dynamics (CFD) were used to assess airplane flying qualities before the maiden flight was performed.

Findings
Extensive data about the aerodynamic characteristics of the airplane were collected. Clean configurations in symmetric and asymmetric cases and also configurations with various control surface deflections were tested.

Practical implications
The data obtained experimentally made it possible to predict the performance and stability properties of the unconventional airplane and to draw conclusions on improvements in further designs of this configuration.

Originality/value
The airplane described in this paper differs from frequently analyzed joined-wing configurations, as it boasts a front lifting surface attached at the top of the fuselage, whereas the aft one is attached at the bottom. The testing technique involving the application of a dual-use model is also innovative.