bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole blood FOLH1 mRNA expression and treatment response in metastatic castration-resistant prostate cancer (mCRPC).
Authors: Kwan Edmond Michael , To Sarah Q , Fettke Heidi C , Docanto Maria M , Bukczynska Patricia , Mant Andrew Michael , Pook David William , Ng Nicole , Graham Lisa-Jane K , Segelov Eva , Mahon Kate , Davis Ian D. , Parente Phillip , Pezaro Carmel Jo , Horvath Lisa , Azad Arun 
Published: March 2019

188 Background: Identifying predictive biomarkers for mCRPC patients receiving androgen receptor signalling inhibitors (ARSI) or chemotherapy remains an unmet clinical need. FOLH1 encodes for Prostate-Specific Membrane Antigen (PSMA), a type II glycoprotein highly expressed on prostate cancer cells. We designed a whole blood assay to detect FOLH1 mRNA, and correlated expression with clinical outcomes in patients commencing ARSI (abiraterone or enzalutamide) or chemotherapy (docetaxel or cabazitaxel). Methods: mCRPC patients commencing ARSI or chemotherapy were prospectively recruited at three Australian centres from June 2016 to July 2018. A quantitative reverse transcription polymerase chain reaction assay was used to detect FOLH1 transcript from whole blood samples collected in PAXgene® RNA tubes. Pre-treatment FOLH1 expression was correlated with PSA response rate (Fisher’s exact test) and PSA progression-free survival (PSA-PFS) (log-rank test). Results: Median follow-up was 13.6 months (IQR 9.7–19.3). In total, 88 pre-treatment samples were analysed, of which 75 (85%) were FOLH1-positive. In patients receiving ARSI, outcomes favoured FOLH1-positive patients compared to FOLH1-negative patients, with higher PSA response rates (39/60, 65% vs. 2/7, 29%; p = 0.1) and longer PSA-PFS (median 9.0 months [95% CI, 7.2-10.8] vs. 2.8 months [95% CI, 2.3-3.3]; p = 0.03). Conversely, in chemotherapy-treated patients, inferior outcomes were observed in FOLH1-positive patients compared to FOLH1-negative patients, with lower PSA response rates (4/15, 27% vs. 5/6, 83%, p = 0.05) and shorter PSA-PFS (median 2.9 months [95% CI, 2.8-3.0] vs. 4.1 months [95% CI, 3.7-4.5]; p = 0.32). Conclusions: Pre-treatment FOLH1 expression may differentiate between outcomes on ARSI vs. chemotherapy in mCRPC patients. The utility of FOLH1 as a predictive biomarker in mCRPC warrants further evaluation in larger, independent cohorts. [Table: see text]
Decreased Early Mortality in Young Adult Patients With Acute Lymphoblastic Leukemia Treated at Specialized Cancer Centers in California
Authors: Alvarez Elysia M. , Malogolowkin Marcio , Li Qian , Brunson Ann , Pollock Brad H. , Muffly Lori , Wun Ted , Keegan Theresa H.M. 
Published: March 2019

PURPOSE: Studies suggest that patients with acute lymphoblastic leukemia (ALL) have superior survival when treated at specialized cancer centers (SCCs). However, the association of early mortality (< 60 days) with location of initial care, sociodemographic factors, and complications has not been evaluated in pediatric and young adult (YA) patients with ALL. METHODS: Using the California Cancer Registry linked to hospitalization data, we identified pediatric and YA patients with ALL who received inpatient leukemia treatment between 1991 and 2014. Patients were classified as receiving all or part/none of their care at an SCC (Children’s Oncology Group– or National Cancer Institute–designated cancer center). Propensity scores were created for treatment at an SCC in each age group. Multivariable, inverse probability–weighted Cox proportional hazards regression models identified factors associated with early mortality. Results are presented as hazard ratios (HRs) and 95% CIs. RESULTS: Among 6,531 newly diagnosed pediatric (≤ 18 years) and YA (19 to 39 years of age) patients with ALL, 1.6% of children and 5.4% of YAs died within 60 days of diagnosis. Most children received all of their care at an SCC (n = 4,752; 85.7%) compared with 35.5% of YAs (n = 1,779). Early mortality rates were lower in pediatric patients and those receiving all care at an SCC (pediatric: all, 1.5%, v part/none, 2.4%; P = .049; YAs: all, 3.2%, v part/none, 6.6%; P = .001). However, in adjusted models, receiving all care at an SCC was associated with significantly lower early mortality in YAs (HR, 0.51; 95% CI, 0.32 to 0.81), but not in pediatric patients (HR, 0.77; 95% CI, 0.47 to 1.25). CONCLUSION: YAs with ALL experience significant reductions in early mortality after treatment at SCCs.
Plasma Fibroblast Growth Factor 21 Is Associated With Severity of Nonalcoholic Steatohepatitis in Patients With Obesity and Type 2 Diabetes
Authors: Barb Diana , Bril Fernando , Kalavalapalli Srilaxmi , Cusi Kenneth 
Published: March 2019

Abstract

Context
The relationship between plasma fibroblast growth factor 21 (FGF21), insulin resistance, and steatohepatitis has not been systematically assessed.

Objective
To determine if higher plasma FGF21 is associated with worse steatohepatitis on liver biopsy in patients with nonalcoholic fatty liver disease (NAFLD).

Design and Setting
Cross-sectional study in a university hospital.

Patients Interventions and Main Outcome Measures
Patients with a body mass index &gt;25 (n = 187) underwent: (i) euglycemic hyperinsulinemic clamp to assess tissue-specific insulin resistance (IR); (ii) liver magnetic resonance spectroscopy for intrahepatic triglyceride quantification, (iii) liver biopsy (if NAFLD present; n = 146); and (iv) fasting plasma FGF21 levels.

Methods and Results
Patients were divided into three groups: (i) No NAFLD (n = 41); (ii) No nonalcoholic steatohepatitis (NASH) (patients with isolated steatosis or borderline NASH; n = 52); and (iii) NASH (patients with definite NASH; n = 94). Groups were well-matched for age/sex, prevalence of type 2 diabetes mellitus, and hemoglobin A1c. During euglycemic hyperinsulinemic insulin clamp, insulin sensitivity in skeletal muscle and adipose tissue worsened from No NAFLD to NASH (both P &lt; 0.001). Plasma FGF21 levels correlated inversely with insulin sensitivity in adipose tissue (r = −0.17, P = 0.006) and skeletal muscle (r = −0.23, P = 0.007), but not with liver insulin sensitivity. Plasma FGF21 was higher in patients with NASH (453 ± 262 pg/mL) when compared with the No NASH (341 ± 198 pg/mL, P = 0.03) or No NAFLD (325 ± 289 pg/mL, P = 0.02) groups. Plasma FGF21 increased with the severity of necroinflammation (P = 0.02), and most significantly with worse fibrosis (P &lt; 0.001), but not with worsening steatosis (P = 0.60).

Conclusions
Plasma FGF21 correlates with severity of steatohepatitis, in particular of fibrosis, in patients with NASH. Measurement of FGF21 may help identify patients at the highest risk of disease progression.
Skeletal Fragility and Its Clinical Determinants in Children With Type 1 Diabetes
Authors: Chen Suet Ching , Shepherd Sheila , McMillan Martin , McNeilly Jane , Foster John , Wong Sze Choong , Robertson Kenneth J , Ahmed S Faisal 
Published: March 2019

AbstractContextType 1 diabetes (T1D) is associated with an increased fracture risk at all ages.ObjectiveTo understand the determinants of bone health and fractures in children with T1D.DesignCase-control study of children with T1D on bone-turnover markers, dual-energy X-ray absorptiometry, and 3 Tesla-MRI of the proximal tibia to assess bone microarchitecture and vertebral marrow adiposity compared with age- and sex-matched healthy children.ResultsThirty-two children with T1D at a median (range) age of 13.7 years (10.4, 16.7) and 26 controls, aged 13.8 years (10.2, 17.8), were recruited. In children with T1D, serum bone-specific alkaline phosphatase (BAP) SD score (SDS), C-terminal telopeptide of type I collagen SDS, and total body (TB) and lumbar spine bone mineral density (BMD) SDS were lower (all P < 0.05). Children with T1D also had lower trabecular volume [0.55 (0.47, 0.63) vs 0.59 (0.47, 0.63); P = 0.024], lower trabecular number [1.67 (1.56, 1.93) vs 1.82 (1.56, 1.99); P = 0.004], and higher trabecular separation [0.27 (0.21, 0.32) vs 0.24 (0.20, 0.33); P = 0.001] than controls. Marrow adiposity was similar in both groups (P = 0.25). Bone formation, as assessed by BAP, was lower in children with poorer glycemic control (P = 0.009) and who were acidotic at initial presentation (P = 0.017) but higher in children on continuous subcutaneous insulin infusion (P = 0.025). Fractures were more likely to be encountered in children with T1D compared with controls (31% vs 19%; P< 0.001). Compared with those without fractures, the T1D children with a fracture history had poorer glycemic control (P = 0.007) and lower TB BMD (P < 0.001) but no differences in bone microarchitecture.ConclusionChildren with T1D display a low bone-turnover state with reduced bone mineralization and poorer bone microarchitecture.
How effective are organ donation committees, and how can they be improved?
Authors: Silva Geeth , Gor Ratan , Patel Nishil , Gupta Shubham , Manivannan Thulashie , Manu Susan , Sharma Ashwini , Gardiner Dale , Cox Benita 
Published: March 2019

Background: Organ donation committees were established in 2008 by NHS Blood and Transplant to improve the rates of organ donation in the UK. Aims: The aims of this study were three-fold: to review the role and structure of organ donation committees in England; to assess how effective organ donation committees are at driving improvements; and to make recommendations regarding the future role, responsibilities and structure of organ donation committees. Methods: This study adopted a cross-sectional mixed-methods research approach using questionnaires and semi-structured interviews. Results: There was a divergence between how each committee functioned and how effective they were in achieving their aims. Discussion: There were seven key findings which related to the effectiveness of organ donation committees. These included, but were not limited to, a lack of consistency in how the role of an organ donation committee was viewed by members of NHS Blood and Transplant; and that the influence a chair has within their respective NHS Trust is key to an organ donation committee being effective in achieving its aims. Conclusion: A framework and several recommendations were produced and aimed to help improve the effectiveness of organ donation committees.
Patient arrival pattern and waiting time analysis for a tertiary hospital radiology department
Authors: Idigo Felicitas Ugochinyere , Agwu Kenneth Kalu , Onwujekwe Obinna Emmanuel , Okeji Mark Chukwudi , Anakwue Angel-Mary Chukwunyelu 
Published: March 2019

Background: High patient load and ineffective appointment scheduling has been linked to hospital overcrowding. This article investigated the appointment scheduling method, patient waiting times and overall treatment times. These figures were subsequently compared against patient arrival and examination times. Method: In total, 768 adult ambulant patients were part of a real-time observation that was conducted in a tertiary hospital's radiology department in Nigeria. The scheduling method, arrival time, treatment time and waiting time for each patient was noted. The analytical software, MATLAB, was used for data analysis. Results: A single block appointment time of 7.30 was given to all patients. For any given day, mean patient arrival per hour (arrival rate) was 7 ± 5.4 patients per hour. Patient arrival rate distribution showed a pattern that resulted in the identification of three segments with stable arrival rates: 7:00–10:00, 10:00-13:00 and 13:00-16:00 with arrival rates of 12, 6 and 2 patients per hour, respectively. The mean waiting time was 116.2 minutes.
Mentor, coach, teacher, role model: what's in a name?
Authors: Power Alison , Wilson Alice 
Published: March 2019

In its new standards for education and training, the Nursing and Midwifery Council (NMC) states that students should be ‘empowered and provided with the learning opportunities they need to achieve the desired proficiencies and programme outcomes’ ( NMC, 2018a:5 ). This concept of empowerment, with students as active, rather than passive learners, will be supported by the introduction of practice assessors and supervisors, providing personalised support according to the student's proficiency and confidence. The mentor, traditionally perceived as a ‘teacher’, will be replaced by the practice assessor and supervisor as ‘role models’ and ‘coaches’. A previous article in this series ( Power and Jewell, 2018 ) looked at the introduction of a coaching model of student support in practice. This article will discuss a third-year student midwife's experiences of her final labour ward placement and her reflections on her mentor's approach to student support using the coaching model.
Meaning from movement: Blurring the temporal border between animation and comics
Authors: Gowdy Joshua 
Published: March 2019

Abstract
This article is informed by my current research in the communicative potential of animated elements within digital comics. Drawing on the writings of Thierry Groensteen and Barbara Postema, I adopt the viewpoint that comics are a complex system in which individual signs and multiple codes combine and interact to communicate meaning. From this foundation, I propose that animated movement can add additional layers of signification, contributing connotative meaning to mostly denotational images. Within the article I recognize that attempts to incorporate animated elements into digital comics have often inadvertently illustrated the difficult relationship and potential incompatibility between cinematic animation and the specific conventions of comics. This discord can be attributed to competing temporal qualities; cinematic animation is a linear time-based art form while time in comics is illusory and implied largely through space. Eschewing a cinematic approach to animation, my research builds on an observation by Daniel Goodbrey (2013) that animated elements are most successfully employed within panels as short animated loops. Unlike linear animated sequences, the indefinite timing of loops does not challenge comics’ temporal code. As exemplars of this more harmonious application of animation to the comic form, Jen Lee’s ThunderPaw: In the Ashes of Fire Mountain (2012–16) is discussed alongside my current studio work, Tepid Waters (Gowdy 2017), a digital comic in which the use of illusionistic movement is secondary to animated elements that communicate on symbolic or connotative levels.
Utilização da ferramenta request for proposal (RFP) nas vendas de um hotel de negócios / Using the request for proposal (RFP) tool in the sales of a business hotel
Authors: Albuquerque Francivaldo Dos Santos , Bezerra Maria Do Socorro Coelho , Silva Alexandre César Batista da , Braulio Giulia Cipolla , Libonati Jeronymo José 
Published: March 2019

O objetivo deste trabalho foi identificar os impactos nas vendas de um hotel de negócios com a utilização da ferramenta RFP. Metodologicamente o trabalho caracteriza-se, quanto aos objetivos, como exploratório e descritivo; com relação aos procedimentos utilizou-se a pesquisa documental, a bibliográfica e o estudo de caso; com relação a abordagem do problema, apresenta-se como uma pesquisa mista. O estudo foi operacionalizado com a análise de dados financeiros e índices de desempenho da empresa, além de entrevista junto a gerente de vendas do hotel. Os resultados demonstram que apesar dos números apresentados não serem aparentemente significativos, quando analisados separadamente, são importantes em relação aos resultados gerais do hotel, mostrando o potencial da ferramenta. Pode-se concluir que os retornos auferidos comprovam impactos positivos para as vendas do hotel, pois a ferramenta influi não apenas nas vendas de hospedagem, mas também em setores como alimentos e bebidas, eventos, telefonia e lavanderia. Palavras-chave: Hotelaria. Vendas. Request for proposal. Impactos.
Cuidados e métodos não-farmacológicos de alívio da dor nas gestantes em trabalho de parto / Non-pharmacological Care and Methods of Pain Relief in Pregnant Women in Labor
Authors: Melo Jayane Kelly Gomes de , Barroso Marianna Leite , Alencar Juliana Saraiva de , Bandeira Luiz Arthur Bevilaqua , Melo Antônio Marlos Duarte de , Mesquita Neto Edmar , Oliveira Gislene Farias de 
Published: March 2019

A dor é uma experiência sensorial subjetiva, que pode alcançar diferente proporções a depender a pessoa, e, dentre várias causas das quais pode decorrer, representa um sinal de início de trabalho de parto para a paciente. O objetivo do presente estudo foi discutir, à luz da literatura sobre os cuidados e métodos não-farmacológicos de alívio da dor nas gestantes em trabalho de parto. Os resultados revelaram diversas estratégias, dentre elas: o relaxamento, a terapia do toque, massagem, hidroterapia, técnicas de respiração. Concliu-se que são positivos os resultados do uso dessas estratégias não farmacológicas no trabalho de parto, como coadjuvante no alívio das dores, motivo pelo qual acreditamos ser importante o desenvolvimento de estudos mais contundentes acerca da temática.
A Percepção e o Perfil Ambiental de Graduandos de Educação a Distância: Um Estudo de Caso / The Perception and Environmental Profile of Students of Distance Education: A Case Study
Authors: Machado Caroline Silva , Albuquerque José De Lima , Quevedo Andressa Pacífico Franco , Correia Neto Jorge Da Silva , Souza Eliabe Roberto De 
Published: March 2019

Esta pesquisa teve por objetivo avaliar a percepção e o perfil ambiental de alunos da Licenciatura em Artes Visuais com ênfase em Digitais da UAEADTEC/UFRPE no Polo Presencial UAB Camaçari/BA. A pesquisa de natureza qualitativa e quantitativa foi realizada por meio de questionário fechado, aplicado para 26 participantes. Os resultados demonstram incertezas quanto a alguns aspectos relacionados à cidadania e meio ambiente e à percepção discente sobre a inserção da temática ambiental na composição das disciplinas do curso. Conclui-se, então, que a percepção ambiental dos discentes está em processo de amadurecimento, porém há necessidade de maiores incentivos quanto à participação ativa nas atividades em sala de aula e no ambiente virtual de aprendizagem, assim como o estímulo periódico na reelaboração do projeto pedagógico do curso.
“Casa das Estrelas”: Uma Análise da Infância na Contemporaneidade / “House of Stars”: A Childhood Analysis in Contemporany
Authors: Oleques Bruna Guerra , Zucolotto Marcele Pereira da Rosa 
Published: March 2019

Neste artigo, pretende-se investigar a criança e a infância tendo como material de análise o livro “Casa das Estrelas – O universo contado pelas crianças”, uma espécie de dicionário onde o significado das palavras é dito pelas crianças. Pretende-se mostrar o quanto os conceitos de criança e de infância foram se modificando ao longo dos séculos, trazendo, na atualidade,possibilidades de inovação, novidade, inventividade, experiência e historicidade. Aponta-se, com estas considerações, a potência de criação das crianças, seu poder de inventividade e o quanto é importante darmos voz a elas.
A Educação Ambiental nos anos Iniciais do Ensino Fundamental / Environmental Education in the Early Years of Elementary Education
Authors: Viana Elaine Cristina Da Silva , Oliveira Júnior Geraldo Martins de , Sobral Elayne Cristina Luz Menezes Novaes Cecílio , Sobral Stevens Emanuel Cecílio , Lima Otoniel Moreira Leite 
Published: March 2019

A Educação Ambiental exerce um papel importantíssimo na contemporaneidade, uma vez que as ações ao meio ambiente, principalmente as antrópicas, tem aumentado consideravelmente no decorrer dos anos. Este trabalho objetivou analisar o ensino da Educação Ambiental em uma instituição, especificamente no fundamental. A metodologia utilizada foi qualitativa. Os dados foram coletados através de entrevista semiestruturada realizada com discentes que cursam 6º e 7º ano, totalizando 50 entrevistados. Todos alunos da escola Municipal Francisco Filgueira Sampaio, em Serrita, Pernambuco. Os resultados demonstraram que os discentes conhecem o conceito de Educação Ambiental, e compreendem que grande parte das ações causadas à natureza partem do homem. Verificou-se que a educação ambiental é trabalhada principalmente nas disciplinas de Ciências e Geografias (55% e 40%, respectivamente). Quanto ao interesse por assuntos relacionados ao Meio Ambiente, 52% tem interesse razoável. Os entrevistados apontaram a necessidade de mais trabalhos relacionados a temática. Constatou-se que a Educação Ambiental é consideravelmente trabalhada com os discentes, porém o interesse pelo assunto ainda é razoavelmente considerado, visto que a metodologia aplicada não estimula-os a prática de ações intervencionistas diretas no meio ambiente, considerando a realidade em que vivem.
A Evolução Conceitual do Goodwill segundo as Teorias do Intangível, Resíduos, Sinergia e Superlucro
Authors: Galindo Jessica Fernanda , Lima Filho Raimundo Nonato , Soares Sandro Vieira 
Published: March 2019

A mudança contínua na sua estrutura e as múltiplas alterações no desenvolvimento do tratamento contábil, com um crescimento rápido e significativo entre todos os outros ativos intangíveis são fatores que justificam o interesse em se pesquisar sobre o goodwill, uma vez que, apesar de ser um tema bastante discutido, ainda permanece em ampla discussão. Assim, este estudo apresenta a evolução conceitual a partir das definições desenvolvidas por estudiosos ao longo das últimas décadas, publicadas em revistas e livros disponíveis em bases e indexadores internacionais e/ou nacionais de Contabilidade. Nesse contexto, o objetivo desta revisão de literatura foi analisar a evolução do conceito goodwilla partir das teorias: intangível, resíduos, sinergia e superlucro, oferecendo uma visão geral das suas definições, para entendê-lo através dos conceitos mencionados por acadêmicos e organismos profissionais de Contabilidade. Esta pesquisa é o resultado de uma análise qualitativa cronológica do conceito de goodwill, trazendo definições existentes datadas a partir de 1897, com os efeitos nas demonstrações contábeis que estão associadas às atividades empresariais, fazendo com que seja de extrema importância para a tomada de decisão.
A Lei Complementar nº 131/2009 (Lei da Transparência) e a Gestão Pública / The Complementary Law 131/2009 (Transparency Law) and Public Management
Authors: Bezerra Letícia Lauany Gomes , Ramos Júlio Cezar Costa 
Published: March 2019

Com o avanço da globalização, o Setor Público vem sofrendo mudanças, sendo uma delas a Lei de Responsabilidade Fiscal nª 101 de 2000. Esta tem objetivos voltados para a responsabilidade e transparência do setor, bem como a Lei da Transparência nº 131 de 2009, que evidencia a divulgação dos dados públicos por meio do portal da transparência. No presente trabalho buscou-se analisar a gestão pública no município de Araripina, sertão de Pernambuco, sobre a evolução da transparência na gestão pública. A pesquisa além de descritiva envolve a legislação e instrumentos da tecnologia da informação relacionados a publicidade das informações da gestão municipal. Os resultados evidenciam que ainda é preciso avançar nos mecanismos contra a corrupção, já que não bastam a existência de leis que obriguem a gestão pública a trabalhar de forma ética e idônea. É necessário uma mudança de paradigmas nos cidadãos. evitando-se os interesses pessoais.