bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep, physical activity, waist circumference and diet as factors that influence health for reproductive age women in northern Greenland
Authors: Watson Zoe A. , Miles Mary P. , Shanks Carmen Byker , Rink Elizabeth 
Published: May 2018

Background: This study explored community and individual factors that influence the health of reproductive age women in a settlement in northern Greenland. This is important because Greenland has a declining population, a high abortion rate and because of projected environmental shifts due to climate change. Methods: This study collected mixed methods data to explore diet, physical activity, sleep and waist circumference for reproductive age women in Kullorsuaq, Greenland. The daily steps and sleeping hours of 13 reproductive age women were measured using activity monitoring bracelets. Waist circumference measurements and in-depth interviews about daily eating and physical activity were conducted with 15 participants and ethnographic participant observations were recorded using field notes. Results: Waist circumference measurements were above recommended cutoffs established by the World Health Organization. Physical activity measured by daily steps was within the ‘active’ range using the cutoff points established by Tudor and Locke. Physical activity is social and is important for communal relationships. Sleeping hours were within normal ranges based on US guidelines; however, the quality of this sleep, its variability across seasons and cultural expectations of what healthy sleep means must be further explored. Diets of women included a mixture of locally harvested meats and imported packaged foods. Study participants experienced less satiety and reported getting hungrier faster when eating packaged foods. This research took place in Spring 2016 and women reported that their sleep, physical activity and diet fluctuate seasonally. Conclusion: The reported findings suggest further investigation of sleep, diet and physical activity combined with the measurement of reproductive hormones to determine linkages between lifestyle factors and reproductive health outcomes is needed.
白川静 “文” 字 “表现 殷人文身说” 的破绽
Authors: 连登岗  
Published: May 2018

摘要 白川静认为 “文” 字的本义是殷人临终时在胸部施加的文身 。 他从两个方面进行了论证: 第一、 “文” 字的甲骨文金文字形 。 第二、殷人的文身习俗 。 论证殷人文身习俗, 他提供了四个方面的论据, 1. 人类学知识 。 2. 与文身相关的系列字 。 3. 实物 。 4. 语言用例 。 白川静的上述观点与论证都存在失误 。 第一、 “文” 字的甲金文字形无法证明它是人临终时加上去的文身符号 。 第二、人类学知识不足以证明殷人存在着文身习俗 。 第三、白川静提供的实物不足以证明殷人存在着文身习俗 。 第四、白川静提供的语言用例不足以证明 “文” 字是人临终时加上去的文身符号 。 第五、白川静对于所谓与文身相关的系列字的解读是错误的 。
From structure topology to chemical composition. XXVI. Crystal structure and chemical composition of a possible new mineral of the murmanite group (seidozerite supergroup), ideally Na2CaTi4(Si2O7)2O4(H2O)4, from the Lovozero alkaline massif, Kola Peninsula, Russia
Authors: Sokolova Elena , Hawthorne Frank C. 
Published: May 2018

AbstractThe crystal structure of a murmanite-related mineral (MRM) of the murmanite group (seidozerite supergroup), ideally Na2CaTi4(Si2O7)2O4(H2O)4, from Mt. Pyalkimpor, the Lovozero alkaline massif, Kola Peninsula, Russia, was refined in space group P$ {\bar 1} $ with a = 5.363(2), b = 7.071(2), c = 12.176(5) Å, α = 92.724(3), β = 107.542(7), γ = 90.13(2)°, V = 439.7(4) Å3 and R1 = 5.72%. On the basis of electron-microprobe analysis, the empirical formula calculated on 22 (O + F), with two constraints derived from structure refinement, OH = 0.11 per formula unit (pfu) and H2O = 3.89 pfu, is (Na2.12K0.07Sr0.01)Σ2.20Ca0.85(Ti3.01Nb0.39Mn0.20Fe2+0.19Mg0.17Zr0.01Al0.01)Σ3.98(Si4.20O14)[O3.90F0.10]Σ4[(H2O)3.89(OH)0.11]Σ4{P0.03}, with Z = 1. It seems unlikely that {P0.03} belongs to MRM itself. The crystal structure of MRM is an array of TS blocks (Titanium-Silicate) connected via hydrogen bonds. The TS block consists of HOH sheets (H = heteropolyhedral, O = octahedral) parallel to (001). In the O sheet, the Ti-dominant MO1 site and Ca-dominant MO2 site give ideally (Ca□)Ti2 pfu. In the H sheet, the Ti-dominant MH site and Na-dominant AP site give ideally Na2Ti2 pfu. The MH and AP polyhedra and Si2O7 groups constitute the H sheet. The ideal structural formula of MRM of the form AP2MH2MO4(Si2O7)2(XOM,A)4(XOA)2(XPM,A)4 is Na2Ti2(Ca□)Ti2(Si2O7)2O4(H2O)4. MRM is a Ca-rich and Na-poor analogue of murmanite, ideally Na2Ti2Na2Ti2(Si2O7)2O4(H2O)4 and a Na-rich and (OH)-poor analogue of calciomurmanite, ideally (Ca□)Ti2(Na□)Ti2(Si2O7)2O2[O(OH)](H2O)4. MRM and (murmanite and calciomurmanite) are related by the following substitutions: O(Ca2+□)MRM ↔ O(Na+2)mur and O(Ca2+□)MRM + H(Na+2)MRM + O(O2–)MRM ↔ O(Na+□)cal + H(Ca2+□)cal + O[(OH)–]cal. MRM is a possible new mineral of the murmanite group (seidozerite supergroup) where Ti + Mn + Mg = 4 apfu.
Clinical, molecular, and immunological responses to pembrolizumab treatment of synchronous melanoma and acute myeloid leukemia
Authors: Kubasch Anne Sophie , Wehner Rebekka , Bazzurri Serena , Tunger Antje , Stasik Sebastian , Garzarolli Marlene , Meinel Jörn , Baretton Gustavo , Meier Friedegund , Thiede Christian , Schmitz Marc , Platzbecker Uwe 
Published: May 2018

Key Points
Pembrolizumab treatment of melanoma and concomitant sAML resulted in a significant platelet response and clearance of IDH1 mutation. Pembrolizumab therapy and response was associated with an increased PD-L1 expression on acute myeloid leukemia blasts and T cells.
Computing the cost of care per day of breast cancer survivor care.
Authors: Blayney Douglas W. , Lindquist Craig , Seto Tina , Hoang Nhat Minh , Kurian Allison W. 
Published: May 2018

10 Background: Cost of breast cancer survivor surveillance, of survivorship care and of variation in care practices are unknown. Furthermore, it is not known whether intense surveillance care adds value. We developed a method to measure the cost of surveillance to account for varying follow-up duration [cost of care per day (CCPD)], and explored the impact of surveillance cost on survival. Methods: We queried the Oncoshare database {Kurian et al Cancer 2014}, which amalgamates data from Stanford Health Care’s (SHC) electronic health record (EHR) (imaging, infused drugs, inpatient and outpatient facility and professional services), from the California Cancer Registry, and the Social Security Death Index. We included breast cancer patients diagnosed 2000-2014, Stages 0-III who had surgery, chemotherapy or radiation treatment at SHC, and who had more than two visits at SHC within 3 years of their treatment completion. We tallied Common Procedural Terminology (CPT©) codes assigned to each service, and mapped each CPT code to the corresponding code and date in the CMS Medicare fee schedule. For patients with breast cancer relapse, we explored the post-relapse survival of the costliest 20% compared with the other patients. Results: CCPD was $2.45 for care delivered at SHC. Among the three breast cancer subtypes (luminal, Her-2 over-expressed and triple negative) there was no difference in cost. Among patients who relapsed, those in the most expensive 20% CCPD had significantly shorter survival than other patients. The high-cost patients had more co-morbidity [cerebrovascular disease (4% for low cost vs 7% for high), chronic pulmonary disease (5% vs 10%), CHF (2% vs 7%), diabetes (4% vs 7%), liver disease (4% vs 9%)]. Conclusions: Cost of care per day (CCPD) is a useful metric to assess value of surveillance and survivorship care, and is also applicable to initial treatment and post-relapse care, to identify “positive deviants” ( those who have developed best practices) in high value care delivery. We captured only costs for treatment at SHC, and merging our data with claims data from 3rd party carriers could increase the accuracy and validity of the CCPD. We identified a model for further testing to reduce total spending for high-quality oncology care.
Disconnect between physical activity guidelines and ground reality: A real world analysis of physical activity profile of cancer survivors.
Authors: Algotar Amit Mohan , Algotar Kalpana , Berkowitz Alyssa , Sanft Tara Beth 
Published: May 2018

105 Background: Physical activity recommendations are often made through survivorship care plans and survivorship guidelines. However, recommendations may not translate into actions and hence it is important to understand the ground reality of cancer survivors and determine how much physical activity they are able to do in their daily life. Methods: Data were obtained from a self-reported survey of patients attending survivorship clinic at a comprehensive cancer center. Participants were asked what kind of physical activity they were engaging in, how many times a week and how many minutes per session. A composite variable was created by multiplying the number of times by number of visits and adding all the activity types patients reported engagement in. This number was compared against the current recommendations of 150minutes of physical activity weekly as recommended National Comprehensive Cancer Network (NCCN) guidelines. Data were stratified by age, gender and cancer type. Results: A total of 729 survivors filled out the survey. Only 26.3% of participants reported meeting the NCCN guideline for physical activity and this did not differ by gender (26.6% female vs 23.9% male). Percent of survivors meeting the guidelines reduced with increasing age (32% < 40 years, 26.5% 40-60 years, and 24% > 60years). Participants with lymphoma reported the highest level of physical activity (113.15 minutes per week) where as those with prostate cancer reported low levels of physical activity (0 minutes per week). Conclusions: This real world analysis demonstrates disconnect between current physical activity guidelines and ground reality of cancer survivors. Not only is research needed to understand barriers of cancer survivors towards achieving physical activity guidelines but attention also needs to be paid to determine if guidelines need to be modified as they may be setting the bar too high.
Cancer survivorship in the rural U.S. Columbia Pacific: A pilot study.
Authors: Lycette Jennifer L. , Cockrum Paulina , Fromwiller Venus , Winters-Stone Kerri M. 
Published: May 2018

106 Background: We provide the only fully staffed cancer center in the rural Columbia Pacific, serving multiple counties in OR and WA. Rural areas can lack resources to provide comprehensive survivorship care. Higher rates of medical comorbidities and socioeconomic barriers add challenges to rural survivorship. We conducted a pilot study to 1) develop a program for lifestyle and behavior modifications to fit the needs of our rural community and 2) determine feasibility and preliminary efficacy of a survivorship program for breast cancer patients. Methods: : 9 women with stage I-III breast cancer completed a 12-week program consisting of 1:1 meetings every 2 weeks with a physical therapist and registered dietician; health coach support; and access to a social worker. The following pre-post measures of physical health were taken: fasting lipids and glucose, HbA1C, waist circumference, blood pressure, BMI, 3-day physical activity log and food journal, joint range of motion, and muscle strength. Pre-post well-being was assessed by EORTC QLQC30 and focus groups. Results: Decreases in systolic BP, weight, waist circumference, fasting glucose, and HbA1c were seen in a majority of participants; however, only decreases in waist circumference reached statistical significance (p = .043). On post-program survey using a 0-10 rating scale, program acceptability was rated at an average of 7, and likelihood to continue at an average of 9.4; however, overall QOL rating had no change. Focus group feedback indicated participants valued dietician visits, but requested more social work support, exercise customization, and group support to foster mentoring, education, and sense of community. Conclusions: Developing a rural comprehensive survivorship care program is feasible. More work is needed to translate physical health goals into enhancement of well-being and improved QOL. As of 10/2/17 we have opened a comprehensive cancer center housing medical oncology and radiation oncology services in one facility. We now have a full-time dietitian, resource coordinator, and social worker. This unique facility is well poised to deliver long-term care to rural cancer survivors, and we believe could serve as a model for other rural regions.
Risk for osteoporosis in gastric cancer survivorship.
Authors: Jeong Sumin , Shin Dong Wook , Lee Ji Eun 
Published: May 2018

121 Background: Gastrectomy is a risk factor for low bone mass. We aimed to investigate the relative risk for osteoporosis in gastric cancer survivorship compared to general population. Methods: Using Korea National Health and Nutrition Examination Survey (KNHANES III-IV), 2008-2011, we identified the 8,156 individuals over 50 years old who have been tested the dual-energy X-ray absorptiometry (DXA). Gastric cancer survivors (n = 103) who had a history of gastric cancer in questionnaire were defined as case. Control subjects were matched to case subjects by age (plus or minus 1 year) and sex with 1:5 ratio. Osteopenia ( -2.5 < T-score < -1.0 ) and osteoporosis (T-score ≤ -2.5) were used to define the status of bone mass. We performed multinominal logistic regression to compare the risk for osteopenia and osteoporosis between case and control. Results: After adjusting for sex, age, body mass index, smoking status, alcohol consumption, physical activity and bone health related history (history of fracture or family history of osteoporosis), there was a significant high risk for osteopenia (adjusted relative risk (RR) = 2.90; 95% confidence interval (CI) 1.16–7.25) and osteoporosis (adjusted RR = 4.63; 95% CI 1.12–13.3) in gastric cancer survivor. The risk for osteoporosis was most prominent for femur total in gastric cancer survivors (adjusted RR = 16.3; 95% CI 3.35–82.6). In addition, the serum Vitamin D level was lower in gastric cancer survivors (20.3 ± 0.5 IU vs 17.5 ± 1.2 IU, p-value = 0.011). Conclusions: Gastric cancer survivors showed significantly high risk for osteoporosis. Our finding clinically implies the importance of managing osteoporosis in gastric cancer survivors.[Table: see text]
Managing childhood cancer survivors at risk for stroke: Practice norms and areas of controversy.
Authors: Kenney Lisa Brazzamano , Ames Bethany , Michaud Alexis L. , Williams David , Ullrich Nicole A. , Manley Peter 
Published: May 2018

124 Background: Childhood cancer survivors (CCS) treated with cranial radiation (CR) are at increased risk for stroke. There is no evidence to guide stroke prevention strategies for CSS. We aimed to describe regional practice norms for managing survivors at risk for stroke and to define areas where management is controversial. Methods: We conducted a Delphi panel of 30 physicians from the New England region who care for CCS, including primary care and specialists. Panelists anonymously answered 3 rounds of open ended questionnaires querying their management approach to a childhood brain tumor survivor treated with CR formatted as 5 clinical scenarios (asymptomatic, large and small vessel cerebral vascular disease (CVD), TIA, stroke), covering 5 categories of management (imaging, lab testing, medication, counseling, referrals). Consensus was defined as ≥ 90% of panelist agreeing with management option. Results: There was a 100% response rate for all 3 rounds of questionnaires. Of the 25 management questions related to 5 clinical scenarios, consensus was reached on 18 while 7 remained controversial. In the scenario of acute stroke symptoms, consensus was reached in all 5 categories of management. In the scenarios of large vessel CVD with symptoms of a TIA, large-vessel CVD without symptoms, and small-vessel CVD without symptoms panelists did not reach consensus on medication, specifically, aspirin use. The primary reasons for disagreement were no evidence for benefit/risk and beyond area of expertise. In the scenario of an asymptomatic survivor with no history of CVD panelists did not reach consensus on indication for MRI surveillance imaging, the primary reasons for disagreement were no clear benefit and risk of findings with uncertain clinical significance. Consensus was not reached on specialty referral patterns in any scenario except acute stroke. Conclusions: Despite lack of evidence to guide stroke prevention in childhood cancer survivors treated with CR, a panel of regional physicians reached consensus on managing most clinical scenarios. Controversial areas requiring further study are follow-up imaging for asymptomatic survivors, aspirin for stroke prophylaxis, and indications for sub-specialty referral.
Successful use of buprenorphine/naloxone to treat opioid addiction after cancer therapy.
Authors: Moryl Natalie 
Published: May 2018

126 Background: Cancer pain prevalence is 55-70% and it is treated with opioids. Tapering opioids after completion of cancer treatment may be complicated by addiction, one of the known side effects of chronic opioid use. To improve access to addiction treatment Suboxone has become widely available to patients with addiction and non-malignant pain. We present a case series of successful use of Suboxone in cancer survivors and patients. Methods: Our comprehensive cancer center (CCC) Pain Registry contains patient characteristics, treatments, and outcomes for a prospective cohort of 2320 chronic pain cancer patients seen in 2011-2016 in outpatient palliative and pain service clinics. We respectively reviewed the database and EMR to evaluate prevalence of addiction and use of Suboxone in cancer pain patients. Results: Of 134 (6%) patients with ICD-9/10 diagnosis of opioid dependence 11 (8%) patients received Suboxone. Eight were male and average age was 55. Eight patients were cancer survivors, one with stable metastatic prostate cancer and two developed end-stage bladder and breast cancer. Eight cancer survivors and one patient with stable metastatic prostate remained on Suboxone and received no other opioids. The two patients with advanced cancers were ultimately taken off Suboxone and discharged to hospice on TD fentanyl and hydromorphone. Suboxone was prescribed by outside prescribers for eight patients and by a CCC certified Suboxone prescriber for three patients: 75-y-o female dependent on morphine for over 10 years was successfully tapered off morphine and ultimately off Suboxone, 51-y-o lymphoma survivor remains in stable remission for addiction, and a 67-y-o man with stable metastatic prostate cancer and stable remission for addiction has been refusing opioids other than Suboxone for 2 years. Conclusions: Although cancer patients are appropriately exempt from CDC opioid guidelines cancer patients with comorbid addiction may benefit from stopping opioids when pain resolves. In addition to screening for opioid use disorder, use of Suboxone may further improve care for the patients with cancer pain and addiction and increase safety for the caregivers and community.
Androgen deprivation therapy (ADT) and cardiovascular mortality (CVD) in men with early-stage prostate cancer (PC) receiving curative radiation therapy (RT).
Authors: Hanlon Ashley , Fleming Steven , Hamilton Ann S , Dinan Michaela Ann , Melloni Chiara , Harrison Michael Roger , Khouri Michel , Wu Xiao-cheng , Wilson J. Frank , Lipscomb Joseph , Cress Rosemary Donaldson , Anderson Roger T , Kimmick Gretchen Genevieve 
Published: May 2018

127 Background: Combined with RT, ADT is a highly effective and utilized treatment for men with localized PC, but some studies suggest that use of ADT leads to increased CVD. We explored the association between ADT and CVD in men receiving RT for localized PC in the National Program for Cancer Registry’s (NPCR) Breast and Prostate Cancer Patterns of Care (POC) study. Methods: From 7 population-based cancer registries, we constructed a sample of men with localized PC treated with definitive RT, stratified by race/ethnicity. Cases diagnosed in 2004 were followed through 2009. Comorbidity, at or before diagnosis, was quantified using the Adult Comorbidity Evaluation 27; subcategories were combined into CV disease (CVD = myocardial infarction, coronary artery disease, congestive heart failure, arrhythmia), CVD-equivalents (CVE = peripheral artery disease and stroke) and CV-risk factors (CVRF = hypertension, diabetes, obesity). Cause of death was determined from the National Death Index data and linkage with vital statistics data. Rates of CV death, in those receiving RT alone versus RT+ADT, were compared in univariate and multivariable analyses. Results: The sample included 2,413 men with mean age 67.7 years (range 39-94), 54.5% white non-Hispanic, 997 received RT alone and 1,416 received RT+ADT. Five-year CVD was 2.3% with RT alone and 3.4% with RT+ADT. In univariate analysis, the following predicted higher CVD with ADT: age < 60 (OR 1.42, p = 0.04), white (OR 2.06, p = 0.001), divorced/separated/widowed (OR 1.29, p = 0.02), insured by Medicare (OR 1.64, p = 0.04), living in mixed urban-rural area (OR 1.87, p = 0.03), higher education level (OR 1.56, p = 0.05), high socioeconomic status (OR 1.70, p = 0.03), no or mild comorbidity level (OR 2.14, p = 0.05 and OR 1.66, p = 0.02, respectively), low PSA (OR 5.44, p = 0,02), and Gleason score 3 (OR 2.12, p = 0.02). In multivariate analysis, use of ADT did not significantly predict hazard of death from heart disease (HR 1.21, p = 0.28) or PC (HR 0.76, p = 0.34). Conclusions: After controlling for confounding variables, use of ADT was not associated with increased risk of CVD in men receiving radiation as definitive therapy for localized PC.
Suicide risk among cancer survivors: Head and neck versus other cancers.
Authors: Osazuwa-Peters Nosayaba , Simpson Matthew C , Zhao Longwen , Adjei Boakye Eric , Olomukoro Stephanie I , Varvares Mark A 
Published: May 2018

146 Background: While head and neck cancer (HNC) only accounts for 4% of new cancer cases in the United States, incidence of HNC-associated suicide may be significantly higher due to quality of life issues associated with HNC survivorship. This study estimated incidence of HNC-associated suicide versus other common cancers, and quantified suicide rate among HNC survivors compared with non-HNC. Methods: We queried the Surveillance, Epidemiology and End Results 18 database from 2000-2014 for all cancer deaths confirmed as suicide. Mortality rates from suicide was estimated for the 21 most common cancers in the United States, including HNC. Negative binomial regression estimated mortality rate ratios (MRRs) and 95% confidence intervals (CIs), between HNC and the other 20 other cancers combined, and as individual sites. Models were stratified by sex (when applicable), controlling for race, marital status, age, year and stage of diagnosis. Results: There were 4,769 suicides observed among 4,613,123 cancer survivors from 2000-2014, yielding an incidence rate of 23.6 suicides per 100,000 person-years. Combined, all other cancers had a 45% decreased suicide ratio compared to HNC for both males (MRR = 0.55, 95% CI 0.48, 0.64) and females (MRR = 0.55, 95% CI 0.37, 0.81). For specific cancer sites, only pancreatic cancer had a higher mortality rate due to suicide than HNC (86.4 suicides per 100,000 person-years, versus 63.4 suicides per 100,000 person-years). Stratified by gender, only male pancreatic cancer survivors had a significantly higher suicide MRR compared with HNC (MRR = 1.54, 95% CI 1.23, 1.90). For females, all cancer sites (including pancreas) had either significantly or insignificantly lower suicide MRR compared with HNC. Conclusions: Risk of suicide is significantly higher among HNC survivors compared to all other cancers, except pancreatic cancer. Our findings confirm that HNC survivors are prime candidates for lifelong psychosocial surveillance.