bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of rotation speed on mechanical properties and microstructure of friction stir spot welding (FSSW) Al 5052 - Steel SS400
Authors: Rojikin Setiyo , Muhayat Nurul , Triyono  
Published: October 2018

Abstract
In this study, the effect of welding parameter such as rotational speed on the mechanical properties and microstructure of friction stir spot welded Al 5052 and SS400 sheet have been investigated. The rotation speed of 1250, 1600, 2000 rpm and the dwell time of 10, were applied to fabricate the friction stir spot welded joint. The microstructure of the joint was observed using scanning electron microscope (SEM). The tensile shear load was measured using by universal testing machine. Base on the microstructure observation showed that the thickness of IMC increases due to the increase of rotational speed. The Maximum thickness of IMCs reached 7.15 µm at 2000 rpm. The result of the tensile shear test showed that the rotational speed is affecting the mechanical properties. The increase of tool rotation speed from 1250 up to 1600 rpm caused the increase of tensile shear load, however further increase up to at 2000 rpm resulted in the decrease of the shear tensile load. The highest shear tensile load reaches 2810.07 N at 1600 rpm.
Analysis of process variables on biodiesel transesterification reaction using Taguchi Method
Authors: Kurniasih E , Pardi P 
Published: October 2018

Abstract
Continuous process for biodiesel production using homogeneous catalysts finds many constraints. Heterogeneous catalysts are the solution for the production of continuous biodiesel. One of the heterogeneous catalysts is zeolite/KIO3. Determination of operating conditions for heterogeneous catalysts, especiallyzeolite/KIO3 is required to obtain appropriate process conditions in order to the continuous system. The Taguchi method is one of experimental design that focuses on the variable approach to product quality improvement by control operation condition. Taguchi method is designed using 4 independent variables with 2 levels (4x2), which are temperature, mole ratio, time reaction and heterogeneous catalyst ratio. The Taguchi method can provide an analysis of the influence of each process variable significantly. This study aims to determine optimal operating conditions for the production of biodiesel with the KIO3 heterogeneous catalyst. Biodiesel is synthesized by esterification (pre-treatment) and transesterification following the Taguchi method. The source of triglyceride is crude palm oil while the alkyl source comes from methanol. Based on the result of analysis Taguchi method known that all process variables have an effect to transesterification reaction. But, variable temperature and reactant mole ratio give the most significant influence and show the interaction with p-value value 0.000 (temperature) and p-value 0.001(reactant mole ratio).Thus, for the production of biodiesel using the KIO3 heterogeneous catalyst obtained optimal operation conditions at temperature 65°C, mole ratio 1:6, time reaction 120 minutes and heterogeneous catalyst ratio at 5% (w/w). ANOVA gave result decided to reject Ho, and decided the reaction model influence by the variable process.
Fuzzy Lookup Table Controller (FLTC) via Center Average De-fuzzifier (CAD) with a New Efficient Heaviside Search Algorithm (HSA) for Lookup Table Implementation
Authors: Wang Chi-Hsu , Hor Kar-Chun , Chen Wei-Chuan 
Published: October 2018

Abstract
This paper proposes an alternate interpretation of the traditional lookup table controller via the Center Average De-fuzzier (CAD) in Fuzzy Set Theory with a set of Disjoint Block Pulse Membership Functions (DBPMFs). Further, a new Heaviside Search Algorithm (HSA) is also proposed to implement the Fuzzy Lookup Table Controller (FLTC) in a more efficient way. The computation complexity of our new HSA is
O
(Σ R
i), where R
i is the number of membership functions for i
th input variable in FLTC. Whereas the average computational complexity in traditional Linear Search Algorithm (LSA) is
O
((П R
i)/2). In comparison with LSA, the HSA also reduces the complexity of coding significantly in the same order as the comparison of computation complexities between HSA and LSA. The balancing of Inverted Pendulum System (IPS) is adopted as the benchmark to show the feasibility and efficiency of this new FLTC and HSA.
European position paper on the management of patients with patent foramen ovale. General approach and left circulation thromboembolism
Authors: Pristipino Christian , Sievert Horst , D’Ascenzo Fabrizio , Louis Mas Jean , Meier Bernhard , Scacciatella Paolo , Hildick-Smith David , Gaita Fiorenzo , Toni Danilo , Kyrle Paul , Thomson John , Derumeaux Genevieve , Onorato Eustaquio , Sibbing Dirk , Germonpré Peter , Berti Sergio , Chessa Massimo , Bedogni Francesco , Dudek Dariusz , Hornung Marius , Zamorano Jose ,   joint task force of European Association of Percutaneous Cardiovascular Interventions (EAPCI), European Stroke Organisation (ESO), European Heart Rhythm Association (EHRA), European Association for Cardiovascular Imaging (EACVI), Association for European Paediatric and Congenital Cardiology (AEPC), ESC Working group on GUCH, ESC Working group on Thrombosis, European Haematological Society (EHA), European Underwater and Baromedical Society (EUBS),   Evidence Synthesis Team, D’Ascenzo Fabrizio , Omedè Pierluigi , Ballocca Flavia , Barbero Umberto , Giordana Francesca , Gili Sebastiano , Iannaccone Mario ,   Eapci Scientific Documents and Initiatives Committee, Capodanno Davide , Valgimigli Marco , Byrne Robert ,   International Experts, Akagi Teiji , Carroll John , Dalvi Bharat , Ge Junbo , Kasner Scott , Michel-Behnke Ina , Pedra Carlos , Rhodes John , Søndergaard Lars , Thomassen Lars , Biondi-Zoccai Giuseppe G L 
Published: September 2018

Abstract
The presence of a patent foramen ovale (PFO) is implicated in the pathogenesis of a number of medical conditions; however, the subject remains controversial and no official statements have been published. This interdisciplinary paper, prepared with involvement of eight European scientific societies, aims to review the available trial evidence and to define the principles needed to guide decision making in patients with PFO. In order to guarantee a strict process, position statements were developed with the use of a modified grading of recommendations assessment, development, and evaluation (GRADE) methodology. A critical qualitative and quantitative evaluation of diagnostic and therapeutic procedures was performed, including assessment of the risk/benefit ratio. The level of evidence and the strength of the position statements of particular management options were weighed and graded according to predefined scales. Despite being based often on limited and non-randomised data, while waiting for more conclusive evidence, it was possible to conclude on a number of position statements regarding a rational general approach to PFO management and to specific considerations regarding left circulation thromboembolism. For some therapeutic aspects, it was possible to express stricter position statements based on randomised trials. This position paper provides the first largely shared, interdisciplinary approach for a rational PFO management based on the best available evidence.
An overview of two open interactive computing environments useful for data science education
Authors: Hoyt Robert , Wangia-Anderson Victoria 
Published: October 2018

Abstract

Objective
To discuss and illustrate the utility of two open collaborative data science platforms, and how they would benefit data science and informatics education.

Methods and Materials
The features of two online data science platforms are outlined. Both are useful for new data projects and both are integrated with common programming languages used for data analysis. One platform focuses more on data exploration and the other focuses on containerizing, visualization, and sharing code repositories.

Results
Both data science platforms are open, free, and allow for collaboration. Both are capable of visual, descriptive, and predictive analytics

Discussion
Data science education benefits by having affordable open and collaborative platforms to conduct a variety of data analyses.

Conclusion
Open collaborative data science platforms are particularly useful for teaching data science skills to clinical and nonclinical informatics students. Commercial data science platforms exist but are cost-prohibitive and generally limited to specific programming languages.
Catheter-Related Staphylococcus aureus Bacteremia and Septic Thrombosis: The Role of Anticoagulation Therapy and Duration of Intravenous Antibiotic Therapy
Authors: Wilson Dib Rita , Chaftari Anne-Marie , Hachem Ray Y , Yuan Ying , Dandachi Dima , Raad Issam I 
Published: October 2018

Abstract

Background
Catheter-related septic thrombosis is suspected in patients with persistent central line–associated bloodstream infection (CLABSI) after 72 hours of appropriate antimicrobial therapy. The clinical diagnosis and management of this entity can be challenging as limited data are available. We retrospectively studied the clinical characteristics of patients with Staphylococcus aureus catheter-related septic thrombosis and the outcomes related to different management strategies.

Methods
This retrospective study included patients with CLABSI due to S. aureus who had concomitant radiographic evidence of catheter site thrombosis treated at our institution between the years 2005 and 2016. We collected data pertaining to patients’ medical history, clinical presentation, management, and outcome within 3 months of bacteremia onset.

Results
A total of 128 patients were included. We found no significant difference in overall outcome between patients who had deep vs superficial thrombosis. Patients with superficial thrombosis were found to have a higher rate of pulmonary complications (25% vs 6%; P = .01) compared with those with deep thrombosis. Patients who received less than 28 days of intravascular antibiotic therapy had higher all-cause mortality (31 vs 5%; P = .001). A multivariate logistic regression analysis identified 2 predictors of treatment failure: ICU admission during their illness (odds ratio [OR], 2.74; 95% confidence interval [CI], 1.08–6.99; P = .034) and not receiving anticoagulation therapy (OR, 0.24; 95% CI, 0.11–0.54; P &lt; .001).

Conclusions
Our findings suggest that the presence of S. aureus CLABSI in the setting of catheter-related thrombosis may warrant prolonged intravascular antimicrobial therapy and administration of anticoagulation therapy in critically ill cancer patients.
Decision-making tools: stochastic simulation model accounting for the impacts of biological variation on success of bovine embryo transfer programs1
Authors: Aherin Dustin G , Bormann Jennifer M , Heier Stamm Jessica L , MacNeil Michael D , Weaber Robert L 
Published: October 2018

AbstractThe objective of the project was to create an economic risk analysis tool for user-defined embryo transfer (ET) programs as an aid in decision-making. Distributions defining the biological uncertainty for many reproductive outcomes are estimated through extensive literature review and limited industry sources. Applying the Latin hypercube variation of Monte Carlo simulation, a sample value from the descriptive distribution associated with each stochastic variable is included in each iteration of the simulation. Through large numbers of iterations with dynamic combinations of variable values, the process culminates in a distribution of possible values for the net present value, annuity equivalent net present value, and return on investment associated with the modeled embryo production scenario. Two options for embryo production, multiple ovulation embryo transfer (MOET) and in vitro embryo production (IVP) from aspirated oocytes, are modeled. Within both MOET and IVP, the use of unsorted or sex-sorted semen is considered, as well as the exception or inclusion of follicular synchronization and/or stimulation before ovum pick-up in IVP procedures. Pretransfer embryo selection through embryo biopsy can also be accounted for when considering in vivo derived embryos. Ample opportunity exists for the commercial application of in-depth, alternative ET scenario assessment afforded through stochastic simulation methodology that the ET industry has not yet fully exploited.
Impact of dietary spray-dried bovine plasma addition on pigs infected with porcine epidemic diarrhea virus
Authors: Duffy Mark A , Chen Qi , Zhang Jianqiang , Halbur Patrick G , Opriessnig Tanja 
Published: October 2018

Abstract
Experimental data suggest that the addition of spray-dried plasma (SDP) to pig feed may enhance antibody responses against certain pathogens and negatively impact virus survival. The benefit of SDP on Escherichia coli infection is well documented. The aim of this study was to determine the effect of bovine SDP (BovSDP) in the pig diet on acute porcine epidemic diarrhea virus (PEDV) infection. A total of 16 3-wk-old conventional crossbred pigs were used and divided into three groups. Treatments included 1) a negative control group fed a commercial diet and sham inoculated with commercial liquid porcine plasma (n = 3), 2) a positive control group fed a commercial diet and inoculated with PEDV-spiked porcine plasma (PEDV; n = 8), and 3) a third group of pigs fed the commercial diet with inclusion of 5% spray-dried bovine plasma and inoculated with PEDV-spiked porcine plasma (BovSDP; n = 5). Although clinical signs associated with PEDV infection were mild in the BovSDP group, two of eight pigs in the PEDV group developed moderate clinical disease and had to be euthanized. The PEDV IgG and IgA antibody levels and prevalence rates were significantly (P &lt; 0.05) higher in the PEDV–BovSDP group compared with the PEDV group at 7 d postinoculation. The average fecal PEDV RNA shedding time was 7.2 ± 1.0 d for the PEDV–BovSDP group and 9.3 ± 1.1 d for the PEDV group with an overall time to clearance of PEDV shedding of 11 d for PEDV–BovSDP pigs and at least 14 d for PEDV pigs, which was not different (P = 0.215). The results indicate that addition of BovSDP induced an earlier anti-PEDV antibody response in pigs experimentally infected with PEDV thereby reducing clinical disease and the amount and duration of viral shedding during acute PEDV infection.
First Pegfilgrastim Biosimilar Approved
Authors: Aschenbrenner Diane S. 
Published: September 2018

Pegfilgrastim-jmdb (Fulphila) is the first approved pegfilgrastim (Neulasta) biosimilar. It is used to prevent infections when neutrophil counts drop as a result of chemotherapy for nonmyeloid cancers.It is not considered interchangeable with pegfilgrastim, meaning it cannot be substituted for pegfilgrastim without consultation with the prescriber.The most common adverse effects of pegfilgrastim-jmdb are bone pain and pain in the extremities. Serious adverse effects are also possible, including spleen rupture, acute respiratory distress syndrome, and serious allergic reactions.
Outcome Differences in Neonates Exposed In-Utero to Opioids Managed in the NICU Versus Pediatric Floor
Authors: Lembeck Amy L. , Tuttle Deborah , Locke Robert , Lawler Laura , Jimenez Pamela , Mackley Amy , Paul David A. 
Published: September 2018

Objective:
The aim of the study is to determine length of stay and length of treatment in infants with neonatal abstinence syndrome (NAS) in the neonatal intensive care unit (NICU) compared to those in the pediatric floor.

Methods:
Retrospective cohort of infants ≥34 weeks gestation admitted with diagnosis of NAS at a single regional perinatal referral center from July 2014 to October 2015. A standardized NAS protocol for both the NICU and pediatric floor, which included guidelines for the initiation of oral morphine, escalation, and weaning, was followed. Initial location of treatment, NICU or pediatric floor, was determined by physiological stability following birth. Statistical analysis included 1-way analysis of variance and chi-square. Multivariable analysis was performed using generalized linear models to account for confounding.

Results:
The study included 235 infants, 80 (34%) were cared for in the NICU. Infants in the NICU had a longer length of stay (27.1 ± 19.1 vs 14.2 ± 10.2 days, P < 0.01), and length of pharmacological treatment (18.0 ± 19.9 vs 9.0 ± 10.2 days, P < 0.01) compared to those on the pediatric floor, respectively. Forty-seven infants were transferred from the NICU to the pediatric floor for the remainder of their hospital stay with a mean time on the pediatric floor of 17.4 ± 14.5 days. After controlling for confounding, admission to the NICU was associated with an increased length of treatment of 12.6 days (95% confidence interval 8.3–16.8) and length of stay of 12.3 days (95% confidence interval 7.9–16.6).

Conclusions:
In our population, admission to the pediatric floor compared to the NICU was associated with a shorter length of stay, and a shorter length of pharmacological treatment. Our data suggest that caring for infants with NAS outside of the NICU setting has the potential to improve short-term outcomes and reduce associated costs.
Surgical Treatment of Dystrophic Scoliosis in Neurofibromatosis Type 1
Authors: Yao Ziming , Guo Dong , Li Hao , Bai Yunsong , Sun Baosheng , Zhang Xuejun , Li Chengxin , Qi Xinyu 
Published: October 2018

Study Design:
This is a retrospective cohort study.

Objective:
To investigate surgical outcomes and instrumentation-related complications (IRCs) of dystrophic scoliosis associated with neurofibromatosis type 1 (NF-1).

Summary of Background Data:
Surgical management, including the growing rod technique and early definitive fusion, has been recommended to avoid progression of NF-1 scoliosis. However, no study has investigated the outcomes and complications of different surgical interventions.

Materials and Methods:
We performed a retrospective review of a cohort of 59 patients diagnosed with NF-1 dystrophic scoliosis and treated surgically. All clinical and radiographic data within a 3-year follow-up period were collected. The patients were divided into 2 groups according to the surgical procedure used: those who underwent initial fusion surgery were assigned to group A (n=32) and those who underwent growing rod surgery to group B (n=27).

Results:
Patients in group A were older than those in group B at the initial surgery (10.4 vs. 5.8 y; P<0.001). There was no difference in the sex ratio, preoperative Cobb angle, or preoperative kyphosis angle between the 2 groups (P>0.05). The correction rate of the main curve Cobb angle was higher in group A than B (55.1% vs. 42.4%; P<0.05). The incidence of IRC was higher in group B than A (48.1% vs. 12.5%; P<0.05). Complications in group A comprised 1 case of screw pullout, 1 case of rod breakage, 1 case of adding-on phenomenon, and 1 case of proximal junctional kyphosis. Complications in group B comprised 5 cases of adding-on phenomenon, 4 cases of trunk shift, 3 cases of curve progression, 1 case of rod breakage, and 1 case of cap loosening.

Conclusions:
The use of growing rod effectively controls the spinal deformity and facilitates growth of the spine. Compared with fusion surgery, however, growing rod surgery yields a higher incidence of IRCs and lower corrective rate for scoliosis associated with NF-1.
Oral Care Protocols With Specialty Training Lead to Safe Oral Care Practices and Reduce Iatrogenic Bleeding in Extracorporeal Membrane Oxygenation Patients
Authors: Lucchini Alberto , Bambi Stefano , de Felippis Christian , Galazzi Alessandro , Addis Grazia , Rona Roberto , Grasselli Giacomo , Pesenti Antonio , Fumagalli Roberto , Foti Giuseppe 
Published: September 2018

Introduction
Oral care, using either a mouth rinse, gel, toothbrush, or combination of them, together with aspiration of secretions, may reduce the risk of ventilator-acquired pneumonia in intubated patents. Oral care procedure in patients on venovenous extracorporeal membrane oxygenation (VV-ECMO) may cause bleeding due to the systemic anticoagulation required.

Purpose
The aim of this study was to investigate the rate of bleeding episodes during oral care in patients supported by VV-ECMO.

Methods
A retrospective observational study was performed. All patients admitted to an Italian ECMO center during 2014 were included in the study.

Results
Data from 14 patients were analyzed. The median intensive care unit length of stay was 39.0 days (interquartile range, 27.3-83.3 days), and median days on VV-ECMO was 19.5 (10.3-46.0). There were 440 ECMO days, with 1320 oral care maneuvers. In 7 patients, bleeding episodes occurred: 2 with orotracheal intubation and 5 initially managed with orotracheal intubation, thereafter via Translaryngeal tracheostomy tube (according to Fantoni’s technique). In 61 oral care procedures (4.6%), bleeding was detected during or after the maneuver, whereas the total numbers of days with at least 1 bleeding episode were 35 (8%).
The presence or absence of bleeding during ECMO days was statistically significant for international normalized ratio (1.01 [0.95-1.11] vs 1.13 [1.03-1.25], P < .0001), platelets (163 000 [93 500-229 000] vs 61 000 [91 00–100 000], P < .0001), and mouth care score (6 [5-7] vs 8 [7-9], P < .001).

Conclusion
Oral care can cause bleeding in patients on VV-ECMO. Implementation of protocols for daily oral care in patients on ECMO may reduce risks. As recommended by the literature, this category of patients should be treated in selected centers distinguished by a regular volume of ECMO activity and the presence of dedicated ECMO specialist nurses.
A Positive Psychology Intervention to Promote Health Behaviors in Heart Failure
Authors: Celano Christopher M. , Freedman Melanie E. , Beale Eleanor E. , Gomez-Bernal Federico , Huffman Jeff C. 
Published: September 2018

Abstract
Patients with heart failure (HF) frequently struggle to adhere to health behaviors, and psychological factors may contribute to nonadherence. We examined the feasibility and acceptability of a 10-week, positive psychology (PP)–based intervention to promote health behavior adherence in patients (N = 10) with mild to moderate HF and suboptimal health behavior adherence. Participants engaged in weekly phone sessions, completed PP exercises (e.g., writing a gratitude letter, using a personal strength), and set goals related to diet, medication adherence, and physical activity. Feasibility was assessed by the number of sessions completed, and acceptability by participant ratings of ease and utility. Preliminary efficacy was measured by changes in psychological and adherence outcomes. The intervention was feasible (87% of exercises completed) and acceptable. Furthermore, in exploratory analyses, the intervention was associated with improvements in psychological and health behavior adherence outcomes. Larger, randomized trials are needed to further investigate the utility of this intervention.
Trial Registration: ClinicalTrials.gov identifier: NCT02938052.
Unraveling the Cause of Anuria Post Kidney Transplantation by Renal Scintigraphy
Authors: Van Keerberghen Ciska-Anne , Naesens Maarten , Gheysens Olivier , Jochmans Ina , Pirenne Jacques , Goffin Karolien 
Published: September 2018

Abstract
A dynamic renal scintigraphy is widely used after renal transplantation to evaluate transplant function and possible complications. We report the case of a 27-year-old man with persisting anuria after kidney transplantation. A renal scintigraphy using 99mTc-ethylenedicysteine followed by SPECT/CT of the abdomen was performed showing tracer accumulation in the colon without any activity in the bladder, as a result of ureter reimplantation onto the sigmoid instead of onto the previously reconstructed bladder. Renal scintigraphy identified the cause and localization of the urinary leak, which led to immediate surgical reimplantation of the ureter onto the augmented bladder with onset of diuresis.