bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remarkable increase of musculoskeletal disorders among soldiers preparing for international missions – comparison between 2002 and 2012
Authors: Halvarsson Alexandra , Seth Monika , Tegern Matthias , Broman Lisbet , Larsson Helena 
Published: October 2019

AbstractBackgroundMusculoskeletal disorders (MSD) are common among soldiers and constitute the most common reason for discontinuing military service within different military populations worldwide. The aims of this study were to investigate the prevalence of musculoskeletal disorders in two cohorts, 10 years apart, in the Swedish Armed Forces, to explore differences between these cohorts and to determine associated factors with MSD.MethodComparative cross-sectional study. Participants were recruited from the Swedish Armed Forces, i.e. soldiers preparing for international missions in 2002 and 2012. A total of 961 soldiers, 7% women, participated in the study.Data were collected using the Musculoskeletal Screening Protocol (MSP), which includes questions regarding prevalence of MSD in ten anatomical locations (neck, upper back, low back, shoulders, elbow, hand, hip, knee, lower limb and foot). An additional five questions concern perceived self-rated health, i.e. how the respondent perceives their own physical body, mental health, social environment, physical environment and work ability.ResultsOver a ten-year period, both point prevalence and one-year prevalence of MSD in any body part increased significantly, with point prevalence increasing from 7.1 to 35.2% (p < 0.001) and one-year prevalence from 27.9 to 67.9% (p < 0.001). The knee was the most common anatomic location for MSD in both cohorts. Across each anatomical location (neck, upper back, low back, shoulders, elbow, hand, hip, knee, lower leg and foot), both point prevalence (p < 0.039) and one-year prevalence (p < 0.005) increased significantly from 2002 to 2012.Most soldiers reported good to excellent perceived health, i.e. self-perception of their physical body, mental health, physical and social environments, and work ability.The odds of reporting one-year prevalence of MSD in any body part was 5.28 times higher for soldiers in Cohort 2012, 1.91 times higher in age group 31–40 and 2.84 times higher in age group 41 and above.ConclusionsThe prevalence of MSD increased remarkably over a ten-year period among Swedish soldiers preparing for international missions. With increasing age as one risk factor, systematic monitoring of MSD throughout the soldiers’ careers and implementation of targeted primary-to-tertiary preventive programs are thus important.
Overexpression of CENPF correlates with poor prognosis and tumor bone metastasis in breast cancer
Authors: Sun Jingbo , Huang Jingzhan , Lan Jin , Zhou Kun , Gao Yuan , Song Zhigao , Deng Yunyao , Liu Lixin , Dong Ying , Liu Xiaolong 
Published: October 2019

Abstract

Background
Centromere Protein F (CENPF) associates with the centromere–kinetochore complex and influences cell proliferation and metastasis in several cancers. The role of CENPF in breast cancer (BC) bone metastasis remains unclear.

Methods
Using the ONCOMINE database, we compared the expression of CENPF in breast cancer and normal tissues. Findings were confirmed in 60 BC patients through immunohistochemical (IHC) staining. Microarray data from GEO and Kaplan–Meier plots were used analyze the overall survival (OS) and relapse free survival (RFS). Using the GEO databases, we compared the expression of CENPF in primary lesions, lung metastasis lesions and bone metastasis lesions, and validated our findings in BALB/C mouse 4T1 BC models. Based on gene set enrichment analysis (GSEA) and western blot, we predicted the mechanisms by which CENPF regulates BC bone metastasis.

Results
The ONCOMINE database and immunohistochemical (IHC) showed higher CENPF expression in BC tissue compared to normal tissue. Kaplan–Meier plots also revealed that high CENPF mRNA expression correlated to poor survival and shorter progression-free survival (RFS). From BALB/C mice 4T1 BC models and the GEO database, CENPF was overexpressed in primary lesions, other target organs, and in bone metastasis. Based on gene set enrichment analysis (GSEA) and western blot, we predicted that CENPF regulates the secretion of parathyroid hormone-related peptide (PTHrP) through its ability to activate PI3K–AKT–mTORC1.

Conclusion
CENPF promotes BC bone metastasis by activating PI3K–AKT–mTORC1 signaling and represents a novel therapeutic target for BC treatment.
Why are olfactory ensheathing cell tumors so rare?
Authors: Murtaza Mariyam , Chacko Anu , Delbaz Ali , Reshamwala Ronak , Rayfield Andrew , McMonagle Brent , St John James A. , Ekberg Jenny A. K. 
Published: October 2019

Abstract
The glial cells of the primary olfactory nervous system, olfactory ensheathing cells (OECs), are unusual in that they rarely form tumors. Only 11 cases, all of which were benign, have been reported to date. In fact, the existence of OEC tumors has been debated as the tumors closely resemble schwannomas (Schwann cell tumors), and there is no definite method for distinguishing the two tumor types. OEC transplantation is a promising therapeutic approach for nervous system injuries, and the fact that OECs are not prone to tumorigenesis is therefore vital. However, why OECs are so resistant to neoplastic transformation remains unknown. The primary olfactory nervous system is a highly dynamic region which continuously undergoes regeneration and neurogenesis throughout life. OECs have key roles in this process, providing structural and neurotrophic support as well as phagocytosing the axonal debris resulting from turnover of neurons. The olfactory mucosa and underlying tissue is also frequently exposed to infectious agents, and OECs have key innate immune roles preventing microbes from invading the central nervous system. It is possible that the unique biological functions of OECs, as well as the dynamic nature of the primary olfactory nervous system, relate to the low incidence of OEC tumors. Here, we summarize the known case reports of OEC tumors, discuss the difficulties of correctly diagnosing them, and examine the possible reasons for their rare incidence. Understanding why OECs rarely form tumors may open avenues for new strategies to combat tumorigenesis in other regions of the nervous system.
An Arthrobacter citreus strain suitable for degrading ε-caprolactam in polyamide waste and accumulation of glutamic acid
Authors: Baxi Nandita N. , Patel Shweta , Hansoti Dipeksha 
Published: October 2019

Abstract
ε-Caprolactam-a toxic xenobiotic compound present in industrial polyamide waste was found to be degraded by caprolactam-degrading bacteria. Arthrobacter citreus was able to utilize up to 20 g ε-caprolactam/l as the sole source of carbon more efficiently as compared to the other Gram positive caprolactam-degrading bacteria Rhodococcus rhodochrous and Bacillus sphaericus. The cells of A. citreus remained viable in medium up to 40 g caprolactam/l. The degradation of 10 g caprolactam/l by A. citreus, when supplied as the sole source of carbon and nitrogen lead to the formation of 6-aminocaproic acid which was detected in broth and there was also an increase in the ammonium content. One of the other metabolites found to consistently accumulate in extracellular medium during the utilization of caprolactam by A. citreus was glutamic acid, though not reported in case of other caprolactam-degrading bacteria. A. citreus could metabolise caprolactam to form non toxic products such as 6-aminocaproic acid and glutamic acid which are amino acids of physiological and commercial importance. In the presence of 6-aminocaproic acid, the rate of caprolactam utilization by A. citreus was decreased but not inhibited and the viable count of cells was found to increase using both the substrates simultaneously. A. citreus was also suitable for degradation of caprolactam in presence of low phosphate as prevalent in soil, and in sterile soil without the supplementation of any other carbon or nitrogen, as well as in native non sterile soil where other microorganisms are present.
CTCF and cellular heterogeneity
Authors: Ren Gang , Zhao Keji 
Published: October 2019

Abstract
Cellular heterogeneity, which was initially defined for tumor cells, is a fundamental property of all cellular systems, ranging from genetic diversity to cell-to-cell variation driven by stochastic molecular interactions involved all cellular processes. Different cells display substantial variation in gene expression and in response to environmental signaling even in an apparently homogeneous population of cells. Recent studies started to reveal the underlying mechanisms for cellular heterogeneity, particularly related to the states of chromatin. Accumulating evidence suggests that CTCF, an important factor regulating chromatin organization, plays a key role in the control of gene expression variation by stabilizing enhancer–promoter interaction.
Cardio embolic stroke and blood biomarkers: diagnosis and predictors of short-term outcome
Authors: Mohamed Wafaa S. , Abd ElGawad Elhady A. , ElMotayam Amal SE. , Fathy Sabah E. 
Published: October 2019

Abstract

Background
The brain is a productive source of a variety of enzymes and any brain injury like a stroke to brain tissue could similarly result in an increase in these enzymes in cerebrospinal fluid and serum. Evaluation of these enzymes represents a simple method for the ischemic stroke subtype diagnosis and prognosis. Objective: This study aimed to determine the role of brain natriuretic peptide (BNP), d-dimer, creatine–kinase-MB (CK-MB), C-reactive protein (CRP) serum levels, and globulin/albumin ratio in the diagnosis of CES stroke and its ability to predict short-term outcome.

Methods
This study was conducted on 96 patients with acute ischemic stroke, subdivided into two groups: group Ι was 48 patients with cardio-embolic stroke and group ΙΙ was 48 patients with non-cardio-embolic. All patients were subjected to the assessment of serum BNP, d-dimer and CK-MB, and CRP and globulin/albumin ratio within the first 24 h of stroke. In the third week, they were assessed by mRS.

Results
The mean levels of BNP, d-dimer level, and CK-MB were significantly higher in patients with cardio-embolic stroke than in patients with non-cardio-embolic stroke (P < 0.001) and also were associated with poor short-term outcome.

Conclusion
Elevated plasma levels of BNP, d-dimer levels, and CK-MB can be used as surrogate biomarkers for the diagnosis of cardio-embolic stroke and prediction of poor short-term outcomes.
Alluvial sedimentation and tectono-stratigraphic evolution in a narrow extensional zigzag basin margin (northern Teruel Basin, Spain)
Authors: Ezquerro Lope , Luzón Aránzazu , Simón José L. , Liesa Carlos L. 
Published: October 2019

Abstract
The northern part of the eastern margin of the extensional Neogene Teruel Basin (central-eastern Spain) consists of a non-linear, zigzag fault zone made of alternating ca. 2 km long, NNW-SSE trending segments and shorter NNE-SSW ones. Good outcrop conditions made possible a comprehensive integrated stratigraphic and structural study, especially focused on coarse clastic sediments deposited along the basin margin. Well-exposed stratal relationships with boundary faults, allowed the analysis of tectonic influence on sedimentation. Synsedimentary deformation includes growth faulting, rollover anticlines, and monoclines and associated onlap stratal terminations, angular unconformities, and other complex growth strata geometries. One of them is the onlap-over-rollover bed arrangement described here for the first time, which reveals the competition between tectonic subsidence and sedimentary supply. Both, the structural inheritance (dense Mesozoic fracture grid) and the dominant, nearly ‘multidirectional’ (σ1 vertical, σ2 ≈ σ3), Pliocene extensional regime with σ3 close to E-W, are considered to have controlled the margin structure and evolution. Tectono-stratigraphic evolution includes: (i) reactivation of inherited NNW-SSE faults and development of W-SW-directed small alluvial fans (SAF) while NNE-SSW segments acted as gentle relay ramp zones; (ii) progressive activation of NNE-SSW faults and development of NW-directed very small alluvial fans (VSAF); during stages i and ii sediments were trapped close to the margin, avoiding widespread progradation; (iii) linking of NNW-SSE and NNE-SSW structural segments, overall basin sinking and widespread alluvial progradation; (iv) fault activity attenuation and alluvial retrogradation. The particular structure and kinematic evolution of this margin controlled alluvial system patterns. Size of alluvial fans, directly set up at the border faults, was conditioned by the narrowness of the margin, small catchment areas, and proximity between faults, which prevented the development of large alluvial fans. The size of the relay zones, only a few hundred meters wide, acted in the same way, avoiding them to act as large sediment transfer areas and large alluvial fans to be established. These features make the Teruel Basin margin different to widely described extensional margins models.
Coverage, Financial Burden, and the Patient Protection and Affordable Care Act for Patients With Cancer
Authors: Segel Joel E. , Jung Jeah 
Published: October 2019

PURPOSE: Evidence suggests coverage has improved significantly for patients with cancer, particularly in the lower-income population, after the implementation of the Affordable Care Act (ACA). Yet no study has examined changes in type of coverage or the resulting effect on spending and financial burden. METHODS: Using 2011 to 2015 Medical Expenditure Panel Survey data, we examine changes in type of coverage, spending, and financial burden among lower-income (< 400% of federal poverty level [FPL]) individuals diagnosed with cancer after the ACA. To better understand the changes, we compare this sample to the lower-income patients without cancer and patients with cancer with a higher income (≥ 400% of FPL). All analyses were conducted in 2018. RESULTS: In adjusted analyses, we found a decline in months uninsured (−0.78 months; P = .001) and an increase in months with Medicaid coverage (0.40 months; P = .059) among the lower-income patients with cancer. This change is similar to the lower-income patients without cancer. We found an increase in total expenditures ($3,020; P = .071) but a modest decline in the fraction of family income spent on health (−0.014; P = 0.099), although neither is statistically significant. For the higher income patients with cancer, we observed significant increases in both out-of-pocket premiums and medical financial burden. CONCLUSION: After the ACA, lower-income people diagnosed with cancer experienced significant gains in coverage largely through Medicaid at rates similar to lower-income patients without cancer, but patients with cancer with incomes 400% or greater of FPL faced a higher financial burden.
Brown Adipose Tissue Response to Cold Stimulation Is Reduced in Girls With Autoimmune Hypothyroidism
Authors: Law James M , Morris David E , Astle Valerie , Finn Ellie , Muros José Joaquín , Robinson Lindsay J , Randell Tabitha , Denvir Louise , Symonds Michael E , Budge Helen 
Published: October 2019

AbstractObjectiveThe interaction between thyroid status and brown adipose tissue (BAT) activation is complex. We assessed the effect of autoimmune hypothyroidism (ATD) in female children on BAT activation, measured using infrared thermography.DesignTwenty-six female participants (14 with ATD and 12 healthy controls) between 5 and 17 years of age attended a single study session. Thermal images were taken of the supraclavicular region before, and after, the introduction of a cool stimulus.ResultsParticipants with ATD had lower resting (hypothyroid, 34.9 ± 0.7°C; control, 35.4 ± 0.5°C; P = 0.03) and stimulated (hypothyroid, 35.0 ± 0.6°C; control, 35.5 ± 0.5°C; P = 0.04) supraclavicular temperatures compared with controls, but there was no difference between groups in the temperature increase with stimulation. BAT activation, calculated as the relative temperature change comparing the supraclavicular temperature to a sternal reference region, was reduced in participants with ATD (hypothyroid, 0.1 ± 0.1°C; control, 0.2 ± 0.2°C; P = 0.04). Children with ATD were frequently biochemically euthyroid due to replacement therapy, but, despite this, increased relative supraclavicular temperature was closely associated with increased TSH (r = 0.7, P = 0.01) concentrations.ConclusionsGirls with ATD had an attenuated thermogenic response to cold stimulation compared with healthy controls, but, contrary to expectation, those with suboptimal biochemical control (with higher TSH) showed increased BAT activation. This suggests that the underlying disease process may have a negative effect on BAT response, but high levels of TSH can mitigate, and even stimulate, BAT activity. In summary, thyroid status is a complex determinant of BAT activity in girls with ATD.
Cognitive Impairment during High-Intensity Exercise: Influence of Cerebral Blood Flow
Authors: KOMIYAMA TAKAAKI , TANOUE YUKIYA , SUDO MIZUKI , COSTELLO JOSEPH T. , UEHARA YOSHINARI , HIGAKI YASUKI , ANDO SOICHI 
Published: October 2019

ABSTRACT

Purpose
Cognitive performance appears to be impaired during high-intensity exercise, and this occurs concurrently with a reduction in cerebral blood flow (CBF). However, it is unclear whether cognitive impairment during high-intensity exercise is associated with reduced CBF. We tested the hypothesis that a reduction in CBF is responsible for impaired cognitive performance during high-intensity exercise.

Methods
Using a randomized crossover design 17 healthy males performed spatial delayed response and Go/No-Go tasks in three conditions (exercise [EX], exercise+CO2 [EX+CO2], and a nonexercising control [CON]). In the EX and EX+CO2, they performed cognitive tasks at rest and during 8 min of moderate and high-intensity exercise. Exercise intensity corresponded to ~50% (moderate) and ~80% (high) of peak oxygen uptake. In the EX+CO2, the participants inspired hypercapnic gas (2% CO2) during high-intensity exercise. In the CON, they performed the cognitive tasks without exercise.

Results
Middle cerebral artery mean velocity increased during high-intensity exercise in the EX+CO2 relative to the EX (69.4 [10.6] cm·s−1, vs 57.2 [7.7] cm·s−1, P < 0.001). Accuracy of the cognitive tasks was impaired during high-intensity exercise in the EX (84.1% [13.3%], P < 0.05) and the EX+ CO2 (85.7 [11.6%], P < 0.05) relative to rest (EX: 95.1% [5.3%], EX+CO2: 95.1 [5.3%]). However, no differences between the EX and the EX+CO2 were observed (P > 0.10). These results demonstrate that restored CBF did not prevent cognitive impairment during high-intensity exercise.

Conclusions
We conclude that a reduction in CBF is not responsible for impaired cognitive performance during high-intensity exercise.
PERCEPÇÕES DA EQUIPE TÉCNICA ESCOLAR E DAS FAMÍLIAS DOS EDUCANDOS NUMA ESCOLA DE REFERÊNCIA DO RIO DE JANEIRO SOBRE BULLYING E O PAPEL DA ORIENTAÇÃO EDUCACIONAL
Authors: Martins Ana Carolina Hyer de Faria da Silva , Barreiros Cláudia Hernandez 
Published: October 2019

Este artigo foi construído a partir da pesquisa de mestrado que resultou na elaboração da dissertação intitulada “‘Nem sempre o adulto resolve’: o serviço de orientação educacional e as práticas de bullying no primeiro segmento do ensino fundamental.”. O recorte elaborado destaca 1) as percepções da equipe escolar e dos responsáveis de educandos sobre o bullying em uma escola de referência do Rio de Janeiro; 2) o papel da orientação educacional e da equipe escolar nas práticas de prevenção e enfrentamento do bullying. Por meio de uma pesquisa qualitativa na qual foram utilizados, como instrumentos de coleta de dados, a entrevista semi-estruturada e a sondagem de opinião, foi possível analisar as formas de bullying presentes na instituição, sua relação com o preconceito e as práticas pedagógicas/ funções de cada agente participante da pesquisa no processo de manutenção, prevenção e enfrentamento do bullying.
EFFECTS OF IGNEOUS INTRUSION ON THE MINERALOGICAL CONTENT OF IRATI FORMATION, PARANÁ BASIN, IN SAPOPEMA (PR), SOUTHERN BRAZIL
Authors: Holanda Werlem , Costa dos Santos Anderson , Nogueira Camila Cardoso , Bertolino Luiz Carlos , Bergamaschi Sérgio , Rodrigues René , Felipe da Costa Diego 
Published: October 2019

Igneous intrusions in sedimentary basins are commonly related with mineralogical association changes in host-rock. At Sapopema region (Paraná State, southern Brazil), an extensive diabase sill (associated to Serra Geral Formation) was emplaced in pelitic-carbonate succession during post-Triassic. The sedimentary host-rock association includes mostly shale, siltstone and carbonate of the Permian Irati Formation. X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) data revealed that heat transfer was not enough to cause modifications in mineral assemblage of the Taquaral Member (quartz + albite + muscovite + illite + kaolinite + chlorite). However, mineralogical content from Assistência Member presented changes probably caused by the intrusion of diabase sill (talc + pyrophyllite + calcite). Talc and calcite were formed due to the reaction between dolomite and quartz, while pyrophyllite was the product of reaction between kaolinite and quartz. EFEITOS DA INTRUSÃO IGNEA NA COMPOSIÇÃO MINERALÓGICA DA FORMAÇÃO IRATI, BACIA DO PARANÁ, SAPOPEMA (PR), SUL DO BRASIL ResumoAs intrusões ígneas em bacias sedimentares dão origem em geral a alterações mineralógicas da rocha hospedeira. Na região de Sapopema (Estado do Paraná, sul do Brasil), uma extensa soleira de diabásio (associada à Formação Serra Geral) pós-Triássica, foi intrudida numa sucessão sedimentar constituída por pelitos e carbonatos. A associação de rochas sedimentares hospedeiras, era principalmente constituída por folhelho, siltito e carbonato da Formação Irati, do Permiano. Dados de difração de raios X (DRX), microscopia eletrônica de varredura (MEV) e espectroscopia de energia dispersiva (EDS) revelaram que a transferência de calor não foi suficiente para causar modificações na composição mineralógica do membro Taquaral (quartzo + albita + moscovita + ilita + caulinita + clorita). No entanto, o conteúdo mineralógico do Membro Assistência apresentou alterações, provavelmente causadas pela intrusão do diabásio (talco + pirofilita + calcita). O talco e a calcita foram formados devido à reação entre dolomita e quartzo, enquanto a pirofilita foi o produto da reação entre a caulinita e o quartzo. Palavras-chave: Bacia Sedimentar. Intrusões Ígneas. Metamorfização de sedimentos. Reações mineralógicas. XRD. SEM / EDS.
Entre les choses, ménager la relation
Authors: Dath Fabienne , Gorza Gildo 
Published: October 2019

L’expérience forte et prégnante de la vie et du travail mené au coeur de la tradition vernaculaire du M’Zab a été déterminante, par la suite, tant dans la pratique de l’architecture que dans l’enseignement à son propos. La question qui a surgi et qui reste première dans nos esprits d’architecte et d’enseignant : comment déployer le vide entre les choses pour assurer la vie du groupe humain et des lieux à construire en relation avec leur milieu. Comment alors définir ses limites et leur matérialité de manière cohérente et mesurée.