bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yanghe Huayan decoction inhibits the capability of trans-endothelium and angiogenesis of HER2+ breast cancer via pAkt signaling
Authors: Liu Xiao-Fei , Li Jing-Wei , Chen Hong-Zhi , Sun Zi-Yuan , Shi Guang-Xi , Zhu Jian-Min , Song Ai-Li , Wang Ying , Li Xiang-Qi 
Published: November 2018

Abstract
Background: Yanghe Huayan Decoction (YHD), a traditional Chinese medicine, is one of the most common complementary medicine currently used in the treatment of breast cancer (BC). It has been recently linked to suppress precancerous lesion and tumor development. The current study sought to explore the role of YHD on trans-endothelium and angiogenesis of BC. Methods: HER2+ BC cells were treated with YHD, Trastuzumab, or the combination in vitro and in vivo to compare the effects of them on trans-endothelium and angiogenesis features. The present study also investigated the potential molecular mechanism of YHD in inhibiting angiogenesis of BC. Results: YHD significantly suppressed the invasion and angiogenesis of BC cells via elevated pAkt signaling. Administration of YHD in vivo also strikingly repressed angiogenesis in tumor grafts. Conclusion: YHD could partially inhibit and reverse tumorigenesis of BC. It also could inhibit Akt activation and angiogenesis in vitro and in vivo. Its effect was superior to trastuzumab. Thus it was suitable for prevention and treatment of BC.
Hautveränderungen als Schlüssel zur Diagnose systemischer Erkrankungen
Authors: Mettang Thomas , Streit Markus 
Published: November 2018

AbstractMany systemic diseases go along with dermal involvement. Only a few of systemic diseases show characteristic skin derangements directly leading to the diagnosis of the underlying disease. Ten of these entities are described within this article. Some of these are autoimmune diseases, such as systemic lupus erythematodes, dermatomyositis or the anti-synthetase-syndrome. Others are genetic diseases with benign or malignant neoplasias (Peutz-Jeghers-syndrome, neurofibromatosis, tuberous sclerosis, Birt-Hogg-Dubé-syndrome, Cowden-syndrome). Other genetically based diseases with typical skin manifestations are characterised by vascular malformations (Pseudoxanthoma elasticum and Osler-Weber-Rendu syndrome) or metabolic and structural organ defects (Morbus Fabry, cystic fibrosis). Being familiar with the typical skin-appearance of these diseases will allow physicians and general practitioners to make a timely diagnosis.
Die Widerspruchslösung in der Organspende: Warum eine alte Fragestellung ihre Aktualität nicht verliert
Authors: Hoppe Nils 
Published: November 2018

ZusammenfassungEs spricht einiges dafür, dass die Einführung einer Widerspruchslösung in Deutschland die historisch niedrigen Spenderzahlen erhöhen würde. Es herrscht zum Teil die Annahme, dass eine solche Reform der Einwilligung in die Organspende an dem politischen Willen der Akteure in Deutschland scheitert. Dieser Artikel umreißt die wesentlichen rechtlichen Rahmenbedingungen und verdeutlicht, dass der verfassungsmäßige Rahmen in Deutschland komplex und für die Aufnahme einer Widerspruchslösung zurzeit nicht geeignet ist. Eine intensivere Debatte sowie ein gesamtgesellschaftlicher Konsens über die Praxis der Widerspruchslösung in einem gegebenenfalls verfassungsrechtlich unsicheren Rahmen wären vonnöten.
Mücken und Zecken als Krankheitsvektoren: der Einfluss der Klimaerwärmung
Authors: Hemmer Christoph , Emmerich Petra , Loebermann Micha , Frimmel Silvius , Reisinger Emil 
Published: November 2018

AbstractDuring the last 135 years, the average temperature in Germany has increased by 1.4 °C. By 2050, a further rise by 1.5 °C is expected. This is associated with an increase of precipitation during the winter months. This climate change probably will improve both the growth conditions for mosquitoes and ticks, as well as their ability to transmit infectious diseases. Today, vectors that have not yet been present are invading into Germany. Among them is Aedes albopictus, which transmits Chikungunya, Zika, and Dengue Fever. Also, spreading of autochthonous malaria and West Nile Fever appear possible in Germany. Because of the increased presence of Phlebotomus species, leishmaniasis should be considered as a potential differential diagnosis in unclear hematologic diseases. Among the tick-borne diseases, climate change has already led to increased case numbers of Borreliosis and Tick Borne Encephalitis (TBE), and Crimean Congo Virus is spreading from the Balkan region towards Central Europe. This requires physicians to consider additional differential diagnoses in febrile illnesses.
Recent Advances in the Synthetic Chemistry of Bicyclo[1.1.1]pentane
Authors: Kanazawa Junichiro , Uchiyama Masanobu 
Published: November 2018

Utilization of three-dimensional cyclic scaffolds is important in modern drug discovery, both to provide greater opportunities for optimizing drug candidates and to expand the available chemical space of drugs. Among these scaffolds, bicyclo[1.1.1]pentane (BCP) is a high-value bioisostere for 1,4-disubstituted phenyl rings, internal alkynes, and the tert-butyl group, generally offering high passive permeability, high water solubility, and improved metabolic stability. However, the lack of methods for functionalizing BCP remains a significant challenge, and in particular, a versatile strategy for synthesizing a wide range of unsymmetrically 1,3-difunctionalized BCP derivatives has been lacking. In this account, we review recent advances in the synthetic chemistry of BCP, focusing especially on our recently developed radical multicomponent carboamination of [1.1.1]propellane.1	Introduction2	Overview of the Synthetic Chemistry of [1.1.1]Propellane, the Most Promising Precursor of Bicyclo[1.1.1]pentane3	Recent Advances in the Synthetic Chemistry of Unsymmetrically 1,3-Disubstituted Bicyclo[1.1.1]pentane Derivatives4	Radical Multicomponent Carboamination of [1.1.1]Propellane Permits Direct Synthesis of 3-Substituted Bicyclo[1.1.1]pent-1-ylamine Derivatives5	Conclusion
Palladium(0)-Catalyzed Difunctionalization of 1,3-Dienes: From Racemic to Enantioselective
Authors: Wu Xiang , Gong Liu-Zhu 
Published: November 2018

1,3-Dienes are easily accessible chemicals that participate in a series of reactions acting on the carbon–carbon double bonds. Catalytic difunctionalization of 1,3-dienes provides a wide scope of functionalized chemicals. Pd(0) catalysts provide a diverse set of principles for the creation of asymmetric catalytic reactions, which are initiated with the oxidative addition and then undergo insertion reaction with one of double bonds of the 1,3-diene to become a π-allyl palladium species that is reactive toward nucleophilic attack. This review summarizes typical advances on the Pd(0)-catalyzed difunctionalization of 1,3-dienes in recent decades, particularly emphasizing the concepts that enable the switch from a racemic reaction to an enantioselective version.1	Introduction2	Amination3	Boration4	Carbonation5	Hydrogenation6	Oxygenation7	Silylation8	Conclusion and Outlook
Electrochemical/Photochemical Aminations Based on Oxidative Cross-Coupling between C–H and N–H
Authors: Zhang Heng , Lei Aiwen 
Published: November 2018

The construction of nitrogen-containing molecules remains at the cutting edge of organic synthesis because of its wide application in various areas. Instead of prefunctionalized substrates, using free C–H and N–H bonds in the starting materials can supply a more sustainable avenue to the C–N bond-forming reactions. Compared with the well-developed transition-metal-catalyzed protocols, the strategy of introducing optical or electrical energy into reactions is fantastic and appealing. As a result, visible light or electricity mediated amination transformations have continued to develop over the past several years. In this short review, recent progress of carbon–nitrogen bond-forming reactions based on the oxidative cross coupling between C(sp2, sp3)–H and N–H are summarized.1	Introduction2	C(sp2)–H/N–H Oxidative Cross Coupling2.1	Aryl C(sp2)–H as C Nucleophiles2.1.1	Azoles as N Nucleophiles2.1.2	Sulfonamides or Sulfonimides as N Nucleophiles2.1.3	NH3 as N Nucleophile2.1.4	Morpholine as N Nucleophile2.1.5	Diaryl Amines as N Nucleophiles2.1.6	Primary Amines as N Nucleophiles2.1.7	Imides as N Nucleophiles2.1.8	Imines as N Nucleophiles2.2	Alkenyl C(sp2)–H as C Nucleophiles2.3	Aldehydic C(sp2)–H as C Nucleophiles3	C(sp3)–H/N–H Oxidative Cross Coupling3.1	Benzylic C(sp3)–H as C Nucleophiles3.2	α-C(sp3)–H as C Nucleophiles4	Conclusions and Outlook
World's First Floating Homeopathic Dispensary
Authors: Rafeeque Muhammed 
Published: November 2018

AbstractFloating Homeopathic Dispensary is a blessing to the people living in the remote islands of the Alappuzha district of Kerala, which is one of the projects of the Department of Homeopathy, Government of Kerala. This dispensary functions in a boat, which moves from one island to the other as per the schedule distributed to the people living in the islands. The team members include a homeopath, pharmacist, attender and the crew members of the boat. Through this project, free treatment is given for both acute and chronic ailments. They also distribute prophylaxis medicines during various epidemics.
A Very Rare Etiology of Hypotonia and Seizures: Congenital Glutamine Synthetase Deficiency
Authors: Ceylaner Serdar , Akın Rıdvan , Ünal Özlem 
Published: November 2018

AbstractMutations in the human GLUL gene, which encodes the enzyme glutamine synthetase (GS), may cause congenital glutamine synthetase deficiency. The disease was first described in 2005 and only three patients have been reported to date. We report a fourth patient suffering from congenital GS deficiency who was found to have some distinctive clinical findings. The patient was a 30-month-old girl who was referred to us due to developmental delay and seizures which began at 5 months of age. She was seizure free for 5 months with valproic acid and vigabatrin. At presentation, she was found to have microcephaly and hypotonia. Her plasma glutamine concentration was near normal and she had mild hyperammonemia. Cranial magnetic resonance imaging (MRI) showed mild changes. Whole exome sequencing (WES) revealed a homozygous c.121C > T (p.R41C) (p.Arg41Cys) pathogenic variant of the GLUL gene. The diagnosis of this patient underlines the importance of careful evaluation of patients with borderline low glutamine levels. Treatment was begun with L-glutamine and nicotinamide and biochemical improvements have been observed at 6 months of follow-up. The outcome of this patient may provide important data about the effectiveness of glutamine and nicotinamide treatment in patients with congenital GS deficiency.
Socio-cultural aspects of diabetes mellitus in Nigeria
Authors: Chinenye S. , Ogbera A. 
Published: November 2018

AbstractUndoubtedly, Nigeria is the most populous country in Africa with about 400 ethnic groups and languages. There is a double burden of disease with rising incidence and prevalence of diabetes mellitus. World Health statistics indicate that Nigeria has the highest number of diabetics in sub-Saharan Africa. In spite of advances in diabetes care and facilities, desired outcomes are not good and linked to this, patient satisfaction is not optimal. Reasons include inadequate attention to biological aspects of diabetes, inadequate or inappropriate pharmacology and psycho-socio-cultural factors. In this review, crucial socio-cultural factors in Nigeria include traditional medicine, religion, diet, physical activity patterns, foot care, awareness, and stress management. Diabetes programs in Nigeria should adopt the principles of education and psycho-social support highlighted by the DAWN study, integrating our socio-cultural heritage, empowering individuals to take charge of their diabetes and achieve desired health outcomes. Religion should be explored as a potential tool to reach out on facts whilst doing away with erroneous beliefs about diabetes mellitus.
Management of depression in diabetes: A review of psycho-social interventions
Authors: Balhara Yatan , Verma Rohit 
Published: November 2018

AbstractDiabetes and depression are major public health problems associated with significant burden. They share many commonalities. Both the diseases have a very high prevalence, mortality, and disability. The current article reviews the available evidence on psycho-social interventions in management of depression in diabetes. A literature search was performed using MEDLINE, PubMed, PsycINFO, Embase, and Cochrane Review for English language articles published during 1960-2012. There is limited published literature on role of psycho-social interventions in management of depression among diabetics. The available evidence suggests that psycho-social interventions, particularly CBT, are effective in improving depression in patients with diabetes. However, these interventions are not consistently associated with improvement in markers of glycemia control (HbA1c levels).
Erfolgreiche Zelltherapie mit virusspezifischen T-Zellen vom HLA-teilkompatiblen Drittspender bei disseminierter Adenovirusinfektion früh nach allogener Stammzelltransplantation
Authors: Kafa Kinan , Tischer Sabine , Heuft Hans-Gert , Blasczyk Rainer , Priesner Christoph , Klusmann Jan-Henning , Eiz-Vesper Britta , Maecker-Kolhoff Britta 
Published: November 2018

ZusammenfassungAdenovirusinfektionen (AdV-Infektionen) nach pädiatrischer hämatopoetischer Stammzelltransplantation sind häufig und treten in 10 – 20% aller allogenen Transplantationen auf (bis 30% der T-Zell-depletierten Transplantationen). Sie sind mit einer hohen Rate an Morbidität und Mortalität verbunden. Da die antivirale Therapie nur virostatisch wirkt und durch erhebliche Toxizität eine limitierende Behandlungsoption darstellt, ist die virusspezifische T-Zell-Therapie als sichere und gut verträgliche komplikationsarme Option sehr attraktiv. Unsere 4-jährige Patientin entwickelte 3 Wochen nach allogener hämatopoetischer Transplantation vom 10/10 HLA-passenden Registerspender eine disseminierte AdV-Infektion (Enteritis, persistierendes Fieber, Sepsis). Eine antivirale Therapie mit Cidofovir zeigte eine gute Wirksamkeit, musste aber wegen erheblicher Nephrotoxizität abgebrochen werden. Unter einer Überbrückungstherapie bis zur geplanten Gabe AdV-spezifischer T-Zellen mit Brincidofovir (BCV) stabilisierte sich die AdV-Last im Blut, blieb aber signifikant hoch. AdV-spezifische T-Zellen der HLA-haploidenten Mutter wurden nach Stimulation mit AdV-Hexon-Peptid-Gemisch über Interferon-γ-Zytokinsekretion (Interferon-γ: IFN-γ) und immunmagnetische Separation aufgereinigt und einmalig in einem Frischpräparat mit einer Dosis von 2,5 × 104 CD3+-Zellen/kg Körpergewicht verabreicht. Die Anwendung verlief komplikationslos und führte zu einer schnellen Elimination des Virus im Blut (ca. nach 2 Wochen). Nahezu zeitgleich (ca. 3 Wochen nach der AdV-spezifischen T-Zell-Gabe) konnten erstmals AdV-spezifische T-Zellen im Patientenblut nachgewiesen werden. Der adoptive Transfer AdV-spezifischer T-Zellen vom HLA-teilpassenden Familienspender als „Third-Party-Spender“ stellt eine rasch verfügbare und wenig toxische Behandlungsoption für Patienten mit refraktärer AdV-Erkrankung dar.
Genetic deletion of vesicular glutamate transporter in dopamine neurons increases vulnerability to MPTP-induced neurotoxicity in mice
Authors: Shen Hui , Marino Rosa Anna M. , McDevitt Ross A. , Bi Guo-Hua , Chen Kai , Madeo Graziella , Lee Pin-Tse , Liang Ying , De Biase Lindsay M. , Su Tsung-Ping , Xi Zheng-Xiong , Bonci Antonello 
Published: November 2018

Significance
Parkinson’s disease (PD) is a chronic dopamine (DA) neuron degenerative disorder. Little is known about factors that impact vulnerability of DA neurons to pathological insults. In this study, we found that vesicular glutamate transporter 2 (VgluT2) expression may play an important role in protecting DA neurons. Selective deletion of VgluT2 in DA neurons led to a significant reduction in expression of brain-derived neurotrophic factor and its receptor tyrosine receptor kinase B and a significant increase in DA neuron death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Restoration of VgluT2 expression in DA neurons reversed these alterations. These findings suggest that reduced VgluT2 expression in DA neurons may constitute a risk factor in the development of PD and suggest potential therapeutic strategies for boosting resilience of DA neurons.
Ubiquilin 2 modulates ALS/FTD-linked FUS–RNA complex dynamics and stress granule formation
Authors: Alexander Elizabeth J. , Ghanbari Niaki Amirhossein , Zhang Tao , Sarkar Jaya , Liu Yang , Nirujogi Raja Sekhar , Pandey Akhilesh , Myong Sua , Wang Jiou 
Published: November 2018

Significance
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating neurodegenerative diseases for which there are few treatments. ALS/FTD has been genetically and pathologically linked to both protein quality control (PQC) factors and RNA homeostasis, but the molecular players that bridge these pathways are not well characterized. Here, we identify a role for the ALS/FTD-linked PQC protein ubiquilin 2 (UBQLN2) in maintaining the solubility of RNA binding protein FUS in response to stress. UBQLN2 increases the dynamics of FUS–RNA complex formation, resulting in the negative regulation of stress granule (SG) formation. Because SGs potentially seed toxic inclusions of patients with ALS/FTD, these findings have implications for understanding ALS/FTD pathogenesis and designing new treatments for these diseases.
Final report, on-going key comparison BIPM.QM-K1, ozone at ambient level, comparison with FMI, November 2017
Authors: Viallon Joële , Idrees Faraz , Moussay Philippe , Wielgosz Robert , Walden Jari , Saarnio Karri 
Published: November 2018

As part of the ongoing key comparison BIPM.QM-K1, a comparison has been performed between the ozone national standard of Finland maintained by the Finnish Meteorological Institute (FMI) and the common reference standard of the key comparison, maintained by the Bureau International des Poids et Mesures (BIPM). The instruments have been compared over a nominal ozone amount-of-substance fraction range from 0 nmol/mol to 500 nmol/mol.
KEY WORDS FOR SEARCH
Ozone, Standard Reference Photometer, BIPM, FMI, KCDB, CIPM MRA

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Final report, on-going key comparison BIPM.QM-K1, ozone at ambient level, comparison with DHMZ, August 2016
Authors: Viallon Joële , Idrees Faraz , Moussay Philippe , Wielgosz Robert , Zobaj Eugen , Lepri Petra , Norris James E , Hodges Joseph T 
Published: November 2018

As part of the on-going key comparison BIPM.QM-K1, a comparison has been performed between the ozone national standard of Croatia maintained by the Meteorological and Hydrological Service (DHMZ) and the common reference standard of the key comparison, maintained by the Bureau International des Poids et Mesures (BIPM), via a transfer standard maintained by the National Institute of Standards and Technology (NIST). The instruments have been compared over a nominal ozone amount-of-substance fraction range of 0 nmol/mol to 500 nmol/mol.
KEY WORDS FOR SEARCH
Ozone, Standard Reference Photometer, BIPM, DHMZ, CIPM MRA, KCDB

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Neurons in the Macaque Dorsal Premotor Cortex Respond to Execution and Observation of Actions
Authors: Papadourakis Vassilis , Raos Vassilis 
Published: November 2018

Abstract
We identified neurons in dorsal premotor cortex (PMd) of the macaque brain that respond during execution and observation of reaching-to-grasp actions, thus fulfilling the mirror neuron (MirN) criterion. During observation, the percentage of grip-selective MirNs in PMd and area F5 were comparable, and the selectivity indices in the two areas were similar. During execution, F5-MirNs were more selective than PMd–MirNs for grip, which was reflected in the higher selectivity indices in F5 than in PMd. PMd displayed grip-related information earlier than F5 during both conditions. In both areas, the number of neurons exhibiting congruent visual and motor selectivity did not differ from that expected by chance. However, both the PMd and F5 neuronal ensembles provided observation–execution matching, suggesting that the congruency may be achieved in a distributed fashion across the selective elements of the population. Furthermore, representational similarity analysis revealed that grip encoding in PMd and F5 is alike during both observation and execution. Our study provides direct evidence of mirror activity in PMd during observation of forelimb movements, and suggests that PMd is a node of the MirN circuit.
Improving the accuracy of two-sample summary-data Mendelian randomization: moving beyond the NOME assumption
Authors: Bowden Jack , Del Greco M Fabiola , Minelli Cosetta , Zhao Qingyuan , Lawlor Debbie A , Sheehan Nuala A , Thompson John , Davey Smith George 
Published: November 2018

Abstract

Background
Two-sample summary-data Mendelian randomization (MR) incorporating multiple genetic variants within a meta-analysis framework is a popular technique for assessing causality in epidemiology. If all genetic variants satisfy the instrumental variable (IV) and necessary modelling assumptions, then their individual ratio estimates of causal effect should be homogeneous. Observed heterogeneity signals that one or more of these assumptions could have been violated.

Methods
Causal estimation and heterogeneity assessment in MR require an approximation for the variance, or equivalently the inverse-variance weight, of each ratio estimate. We show that the most popular ‘first-order’ weights can lead to an inflation in the chances of detecting heterogeneity when in fact it is not present. Conversely, ostensibly more accurate ‘second-order’ weights can dramatically increase the chances of failing to detect heterogeneity when it is truly present. We derive modified weights to mitigate both of these adverse effects.

Results
Using Monte Carlo simulations, we show that the modified weights outperform first- and second-order weights in terms of heterogeneity quantification. Modified weights are also shown to remove the phenomenon of regression dilution bias in MR estimates obtained from weak instruments, unlike those obtained using first- and second-order weights. However, with small numbers of weak instruments, this comes at the cost of a reduction in estimate precision and power to detect a causal effect compared with first-order weighting. Moreover, first-order weights always furnish unbiased estimates and preserve the type I error rate under the causal null. We illustrate the utility of the new method using data from a recent two-sample summary-data MR analysis to assess the causal role of systolic blood pressure on coronary heart disease risk.

Conclusions
We propose the use of modified weights within two-sample summary-data MR studies for accurately quantifying heterogeneity and detecting outliers in the presence of weak instruments. Modified weights also have an important role to play in terms of causal estimation (in tandem with first-order weights) but further research is required to understand their strengths and weaknesses in specific settings.