bluuebunny/crossref_metadata_2025_split huggingface dataset:
Routing entanglement in the quantum internet
Authors: Pant Mihir , Krovi Hari , Towsley Don , Tassiulas Leandros , Jiang Liang , Basu Prithwish , Englund Dirk , Guha Saikat 
Published: March 2019

AbstractRemote quantum entanglement can enable numerous applications including distributed quantum computation, secure communication, and precision sensing. We consider how a quantum network—nodes equipped with limited quantum processing capabilities connected via lossy optical links—can distribute high-rate entanglement simultaneously between multiple pairs of users. We develop protocols for such quantum “repeater” nodes, which enable a pair of users to achieve large gains in entanglement rates over using a linear chain of quantum repeaters, by exploiting the diversity of multiple paths in the network. Additionally, we develop repeater protocols that enable multiple user pairs to generate entanglement simultaneously at rates that can far exceed what is possible with repeaters time sharing among assisting individual entanglement flows. Our results suggest that the early-stage development of quantum memories with short coherence times and implementations of probabilistic Bell-state measurements can have a much more profound impact on quantum networks than may be apparent from analyzing linear repeater chains. This framework should spur the development of a general quantum network theory, bringing together quantum memory physics, quantum information theory, quantum error correction, and computer network theory.
Matrix effect on surface-catalyzed photolysis of nitric acid
Authors: Ye Chunxiang , Zhang Ning , Gao Honglian , Zhou Xianliang 
Published: March 2019

AbstractPhotolysis rate constant of HNO3on the surface (HNO3(s)) has been found to be enhanced by 1–4 orders of magnitude from that of gaseous HNO3, with HONO and NO2as the main products. Such Re-NOx-ification pathway extends the apparent lifetime of reactive nitrogen species and modifies the atmospheric oxidative capacity along its long-rang transport. Despite of its importance, the detailed kinetics and mechanisms of HNO3(s)photolysis are still not clear. Surface film of HNO3and organic compounds is ubiquitous in the environment and imposes matrix effect on HNO3(s)photolysis. Here we studied photolysis of HNO3on Pyrex glass in a photochemical flow reactor over a wide range of HNO3surface density (DHNO3) with or without the presence of model organic compounds. The photolysis rate constant of HNO3(s)varied withDHNO3and surface-catalysis mechanism was proposed. Organic compounds further enhance the photolysis rate constant by up to one order of magnitude via both photosensitization and H-donating reaction. The H-donating reaction enhances as well the secondary HONO yield from reaction between the primary product NO2and adjacent H-donor, and thus increases the HONO/NO2production ratio. Finally, detailed mechanisms involving surface-catalyisis, photosensitization and H-donating reactions was integrated.
Sedimentary record from Patagonia, southern Chile supports cosmic-impact triggering of biomass burning, climate change, and megafaunal extinctions at 12.8 ka
Authors: Pino Mario , Abarzúa Ana M. , Astorga Giselle , Martel-Cea Alejandra , Cossio-Montecinos Nathalie , Navarro R. Ximena , Lira Maria Paz , Labarca Rafael , LeCompte Malcolm A. , Adedeji Victor , Moore Christopher R. , Bunch Ted E. , Mooney Charles , Wolbach Wendy S. , West Allen , Kennett James P. 
Published: March 2019

AbstractThe Younger Dryas (YD) impact hypothesis posits that fragments of a large, disintegrating asteroid/comet struck North America, South America, Europe, and western Asia ~12,800 years ago. Multiple airbursts/impacts produced the YD boundary layer (YDB), depositing peak concentrations of platinum, high-temperature spherules, meltglass, and nanodiamonds, forming an isochronous datum at >50 sites across ~50 million km² of Earth’s surface. This proposed event triggered extensive biomass burning, brief impact winter, YD climate change, and contributed to extinctions of late Pleistocene megafauna. In the most extensive investigation south of the equator, we report on a ~12,800-year-old sequence at Pilauco, Chile (~40°S), that exhibits peak YD boundary concentrations of platinum, gold, high-temperature iron- and chromium-rich spherules, and native iron particles rarely found in nature. A major peak in charcoal abundance marks an intense biomass-burning episode, synchronous with dramatic changes in vegetation, including a high-disturbance regime, seasonality in precipitation, and warmer conditions. This is anti-phased with northern-hemispheric cooling at the YD onset, whose rapidity suggests atmospheric linkage. The sudden disappearance of megafaunal remains and dung fungi in the YDB layer at Pilauco correlates with megafaunal extinctions across the Americas. The Pilauco record appears consistent with YDB impact evidence found at sites on four continents.
Achieving excellent superplasticity of Mg-7Zn-5Gd-0.6Zr alloy at low temperature regime
Authors: Yin Siqi , Zhang Zhiqiang , Yu Jiamin , Zhao Zilong , Liu Min , Bao Lei , Jia Zheng , Cui Jianzhong , Wang Ping 
Published: March 2019

AbstractMg-7Zn-5Gd-0.6Zr (wt%) alloy strengthened with quasicrystal phase (I-Mg3Zn6Gd phase) is prepared through hot extrusion and subsequent heat treatments. The low temperature (range from 25 °C to 250 °C) superplastic deformation behavior of the as-extruded, aging treated (T5) and solution and aging treated (T6) alloys are investigated. The results reveal that a superior superplastic elongation of 863% is obtained at 250 °C and strain rate of 1.67 × 10−3 s−1 and the elongation of this alloy increases with the increasing tensile temperature. Detailed microstructural analyses show that I-Mg3Zn6Gd phase and W-Mg3Gd2Zn3 phase are crushed into small particles during extrusion. A high density of nanoscale I-phase precipitates after T5 treatment. Dynamic recrystallization occurs in as-extruded Mg-7Zn-5Gd-0.6Zr alloy. The T5-treated Mg-7Zn-5Gd-0.6Zr alloy shows a relatively weak basal texture intensity, a large number fraction of high angle boundaries and a very finer grain structure (3.01 μm). During superplastic deformation, the nanoscale I-phase is slightly elongated and the microstructure is still equiaxed grains. The superplastic mechanism of the alloy is grain boundary sliding (GBS) accommodated by dislocation movement and static recrystallization. The cavity nucleation at the nanoscale I-phase/α-Mg matrix boundaries or grain boundaries and the cavity stringer formation leads to final fracture.
Spicatoside A derived from Liriope platyphylla root ethanol extract inhibits hepatitis E virus genotype 3 replication in vitro
Authors: Park Gayoung , Parveen Amna , Kim Jung-Eun , Cho Kyo Hee , Kim Sun Yeou , Park Bang Ju , Song Yoon-Jae 
Published: March 2019

AbstractHepatitis E virus (HEV) is the causative agent of hepatitis E in humans worldwide. Although hepatitis E is self-limiting without chronic infection development, HEV infection often leads to severe liver diseases causing high mortality in pregnant women in addition to chronic hepatitis and cirrhosis in immunosuppressed patients. In this study, we investigated the effect of a Liriope platyphylla ethanol extract (LPE) on HEV replication. Interestingly, LPE suppressed replication of the genotype 3 HEV replicon. Sequential solvent fractionation revealed that the ethyl acetate (EA) fraction of LPE exerts the most potent inhibitory effects. With the aid of activity-guided fractionation and multi-step column chromatography, spicatoside A was subsequently isolated in the EA fraction of LPE and specifically shown to exert inhibitory effects on replication of the genotype 3 HEV replicon. In addition, spicatoside A interfered with replication of the HEV genotype 3 strain 47832c and expression of HEV ORF2 capsid proteins. Our findings clearly support the potential utility of spicatoside A as an effective anti-HEV agent.
Different somatostatin and CXCR4 chemokine receptor expression in gastroenteropancreatic neuroendocrine neoplasms depending on their origin
Authors: Mai Rebekka , Kaemmerer Daniel , Träger Tina , Neubauer Elisa , Sänger Jörg , Baum Richard P. , Schulz Stefan , Lupp Amelie 
Published: March 2019

AbstractSomatostatin receptors (SST), especially SST2A, are known for their overexpression in well-differentiated gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). The chemokine receptor CXCR4, in contrast, is considered to be present mainly in highly proliferative and advanced tumors. However, comprehensive data are still lacking on potential differences in SST or CXCR4 expression pattern in GEP-NEN in dependence on the place of origin. Overall, 412 samples from 165 GEP-NEN patients, comprising both primary tumors (PT) and metastases (MTS), originating from different parts of the gastrointestinal tract or the pancreas were evaluated for SST and CXCR4 expression by means of immunohistochemistry using monoclonal antibodies. SST2A was present in 85% of PT with a high intensity of expression, followed by SST5 (23%), CXCR4 (21%), SST3 (10%), SST1 (9%), and SST4 (4%). PT displayed higher SST2A and chromogranin A (CgA) expression levels than MTS. In both PT and MTS lower SST2A and CgA expression levels were found in tumors originating from the appendix or colon, compared to tumors from other origins. Tumors derived from appendix or colon were associated with significantly worse patient outcomes. Positive correlations were noted between SST2A and CgA as well as between CXCR4 and Ki-67 expression levels. SST2A and CgA negativity of the tumors was significantly associated with poor patient outcomes. All in all, SST2A was the most prominent receptor expressed in the GEP-NEN samples investigated. However, expression levels varied considerably depending on the location of the primary tumor.
Pressure-sensitive liquid phase epitaxy of highly-doped n-type SiGe crystals for thermoelectric applications
Authors: Li Hung-Wei , Chang Chih-Wei 
Published: March 2019

AbstractBased on recent works, the most desirable high-temperature thermoelectric material would be highly-doped Si1−xGex crystals or films with sufficiently high Ge concentrations so that simultaneous enhancing the power factor and wave-engineering of phonons could be possible on the ballistic thermal conductor. However, available thin film deposition methods such as metal organic chemical vapor deposition, electron-beam evaporation, or sputtering are unable to produce highly-doped SiGe single crystals or thick films of high quality. To fabricate the desired material, we here employ liquid phase epitaxy to make highly-doped (up to 2% GaP doping) SiGe crystals with minimized concentration variations on Si (111) and (100) substrates. We find that growing Si1−xGex (x = 0.05~0.25) crystals from Ga solvents at relatively high vacuum pressure (0.1 torr) displays significant deviations from previous calculated phase diagram. Moreover, doping GaP into SiGe is found to affect the solubility of the system but not the resulting Ge concentration. We thus plot a new pressure-dependent phase diagram. We further demonstrate that the new pressure-induced liquid phase epitaxy technique can yield Si1−xGex crystals of much higher Ge concentrations (x > 0.8) than those grown by the conventional method.
Multiomics analysis profile acute liver injury module clusters to compare the therapeutic efficacy of bifendate and muaddil sapra
Authors: Talifu Ainiwaer , Saimaiti Refuhati , Maitinuer Yusufu , Liu Geyu , Abudureyimu Miernisha , Xin Xuelei 
Published: March 2019

AbstractThe pathogenesis of acute liver injury has been plagued by biologists and physicians. We know little about its therapeutic mechanism. Therefore, this study explored the mechanism of bifendate and muaddil sapra in the treatment of acute liver injury. Firstly, co-expression and cluster analysis of disease-related genes were carried out, and the Go function and KEGG pathway of modules and related genes were identified. Secondly, pivot analysis of modules can identify key regulators. On the other hand, based on the acute liver injury induced by CCl4, we use the combined analysis of proteomics and transcriptome to find therapeutic targets and related mechanisms of drugs. A total of 21 dysfunction modules were obtained, which were significantly involved in immune system, hepatitis and other related functions and pathways. Transcriptome analysis showed 117 targets for bifendate treatment, while 119 for muaddil sapra. Through exploring the mechanism, we found that the two drugs could modulate the module genes. Moreover, bifendate regulate the dysfunction module through ncRNA (SNORD43 and RNU11). Muaddil sapra can mediate dysfunction modules not only by regulating ncRNA (PRIM2 and PIP5K1B), but also by regulating TF (STAT1 and IRF8), thus having a wider therapeutic potential. On the other hand, proteome analysis showed that bifendate mainly regulated Rac2, Fermt3 and Plg, while muaddil sapra mainly regulated Sqle and Stat1. In addition, muaddil sapra regulates less metabolic related proteins to make them more effective. Overall, this study not only provides basic theory for further study of the complex pathogenesis of acute liver injury, but also provides valuable reference for clinical use of bifendate and muaddil sapra in the treatment of acute liver injury.
Robust optomechanical state transfer under composite phase driving
Authors: Ventura-Velázquez C. , Jaramillo Ávila Benjamín , Kyoseva Elica , Rodríguez-Lara B. M. 
Published: March 2019

AbstractWe propose a technique for robust optomechanical state transfer using phase-tailored composite pulse driving with constant amplitude. Our proposal is inspired by coherent control techniques in lossless driven qubits. We demonstrate that there exist optimal phases for maximally robust excitation exchange in lossy strongly-driven optomechanical state transfer. In addition, our proposed composite phase driving also protects against random variations in the parameters of the system. However, this driving can take the system out of its steady state. For this reason, we use the ideal optimal phases to produce smooth sequences that both maintain the system close to its steady state and optimize the robustness of optomechanical state transfer.
Repeated administration of the NSAID meloxicam alters the plasma and urine lipidome
Authors: Rivera-Velez Sol M. , Broughton-Neiswanger Liam E. , Suarez Martin , Piñeyro Pablo , Navas Jinna , Chen Sandy , Hwang Julianne , Villarino Nicolas F. 
Published: March 2019

AbstractNon-steroidal anti-inflammatories (NSAIDs), such as meloxicam, are the mainstay for treating painful and inflammatory conditions in animals and humans; however, the repeated administration ofNSAIDscan cause adverse effects, limiting the long-term administration of these drugs to some patients. The primary aim of this study was to determine the effects of repeated meloxicam administration on the feline plasma and urine lipidome. Cats (n = 12) were treated subcutaneously with either saline solution or 0.3 mg/kg body weight of meloxicam daily for up to 31 days. Plasma and urine lipidome were determined by LC-MS before the first treatment and at 4, 9 and 13 and 17 days after the first administration of meloxicam. The repeated administration of meloxicam altered the feline plasma and urine lipidome as demonstrated by multivariate statistical analysis. The intensities of 94 out of 195 plasma lipids were altered by the repeated administration of meloxicam to cats (p < 0.05). Furthermore, we identified 12 lipids in plasma and 10 lipids in urine that could serve as biomarker candidates for discriminating animals receiving NSAIDs from healthy controls. Expanding our understanding about the effects of NSAIDs in the body could lead to the discovery of mechanism(s) associated with intolerance to NSAIDs.
Rg6, a rare ginsenoside, inhibits systemic inflammation through the induction of interleukin-10 and microRNA-146a
Authors: Paik Seungwha , Choe Jin Ho , Choi Ga-Eun , Kim Ji-Eun , Kim Jin-Man , Song Gyu Yong , Jo Eun-Kyeong 
Published: March 2019

AbstractThe immunobiological functions of Rg6, a rare ginsenoside from ginseng, have been largely unreported. In this paper, we demonstrate that Rg6 has a significant immunosuppressive function on Toll-like receptor (TLR) 4-induced systemic inflammatory responses. Rg6 was found to negatively regulate pro-inflammatory responses and severityin vivo, and thus induced recovery in mice with lipopolysaccharide (LPS)-induced septic shock and cecal ligation and puncture (CLP)-induced sepsis. Rg6 treatment also facilitated recovery in mice with LPS-induced lung damage via reduced neutrophil infiltration and tumor necrosis factor-α expression in lung tissues. Rg6 injection also downregulated pro-inflammatory cytokines and increased the levels of interleukin (IL)-10 in the serum of septic mice. Mechanistically, Rg6 did not induce TLR negative regulators, such as A20 and IRAK-M, in bone marrow-derived macrophages (BMDMs). Instead, addition of Rg6 to LPS-activated BMDMs augmented IL-10 expression, whereas it inhibited inflammatory signaling, such as by nuclear factor κB activation and mitogen-activated protein kinases. Furthermore, Rg6 significantly induced miR-146a, an operator miRNA for anti-inflammation, in BMDMs. Collectively, these data indicate that Rg6 inhibits inflammatory responses through the induction of IL-10 and miR-146a.
Growth of Plasma-Treated Corn Seeds under Realistic Conditions
Authors: Ahn Chisung , Gill John , Ruzic David N. 
Published: March 2019

AbstractIn this study, the effect of the plasma treatment on corn seeds is investigated. Corn seeds were treated uniformly without burning or blackening by three kinds of plasma apparatus: RF plasma in vacuum, microwave-driven atmospheric-pressure plasma, DBD atmospheric-pressure plasma, and two other treatments: vacuum exposure only, and using plasma-activated water in the seed coating process, to investigate growth rate changes under realistic conditions. Each treatment was performed on a total of 1512 corn seeds. Seeds from each experimental condition were treated with the recommended rate of Poncho/VOTiVO with Acceleron, a commercial biological seed treatment that helps to protect the seeds from fungus, insects, and nematodes after planting. The 1512 seeds were divided evenly into three replications with 84 seeds planted for each replication at six unique locations across central Illinois. The results for germination, growth, and product yield over the 2017 growing season is presented. Overall no statistically significant difference in the yield of corn harvested was found between the control and any of the five treatments. This is likely due to the already near-100% germination rate of the corn hybrid used in the study and the use of the Poncho/VOTiVO protective coating on every sample.
Reduced sperm telomere length in individuals with varicocele is associated with reduced genomic integrity
Authors: Tahamtan Sahar , Tavalaee Marziyeh , Izadi Tayebeh , Barikrow Nooshin , Zakeri Zahra , Lockshin Richard A. , Abbasi Homayoun , Nasr- Esfahani Mohammad Hosseini 
Published: March 2019

AbstractVaricocele, defined as enlarged varicose veins in the scrotum, is the most common identifiable cause of male infertility. There are significant correlations between oxidative stress and varicocele-related infertility due to testicular hyperthermia, which can result in low sperm function. In addition, recent excessive oxidative stress can affect sperm telomere length and integrity of sperm DNA. Therefore, we assessed sperm telomere length as a potential marker of paternal genome integrity and leukocyte telomere length as an internal control (real-time PCR), along with sperm chromatin status (TUNEL and chromomycin A3 assay), and lipid peroxidation (Bodipy probe) in 18 infertile men with grade II or III varicocele, and 20 fertile men. Means of sperm parameters, sperm and leukocyte telomere length were significantly lower, while means of sperm DNA fragmentation, protamine deficiency, and lipid peroxidation were significantly higher in infertile men with varicocele compared to fertile men. Therefore, shortened telomere length in sperm and leukocytes is likely associated with increased oxidative stress related to the state of varicocele, which also accounts for increase in sperm DNA fragmentation. Thus, assessment of leukocyte telomere length could be taken as an indicator of antioxidant capacity in an individual, which also affects sperm function.
Hospital Results of a Single Center Database for Stentless Xenograft Use in a Full Root Technique in Over 970 Patients
Authors: Easo Jerry , Weymann Alexander , Hölzl Philipp , Horst Michael , Eichstaedt Harald , Mashhour Ahmed , Zhigalov Konstantin , Szczechowicz Marcin , Thomas Rohit Philip , Sabashnikov Anton , Dapunt Otto E. 
Published: March 2019

AbstractOur aim was to analyse the hospital outcome for the worldwide largest series of stentless bioroot xenografts (Medtronic Freestyle) as full root replacement in a single centre over a period of 18 years. Retrospective data analysis was performed for the entire cohort of patients undergoing aortic root surgery with the Medtronic Freestyle valve prosthesis. Logistic regression analysis was performed to analyse predictors of in-hospital mortality. 971 patients underwent aortic full root replacement with the Medtronic Freestyle valve in the period from 1999–2017, with an average age of 68.8 ± 10.3y and gender distribution of 608:363 (male:female). Concomitant surgery was performed in 693 patients (71.4%). In-hospital all-comers mortality was 9.8% (95 patients), with the respective highest risk profiles including dissections (6.4%), endocarditis (5.6%) and re-do procedures (12.5%). In-hospital mortality for elective patients was 7.6% while isolated aortic root replacement demonstrated a mortality of 3.6%. Logistic regression analysis demonstrated age (OR 1.05, p = 0.005), dissection (OR 5.78, p < 0.001) and concomitant bypass surgery (OR 2.68, p < 0.001) as preoperative risk factors for the entire cohort. Postoperative analysis demonstrated myocardial infarction (OR 48.6, p < 0.001) and acute kidney injury (OR 20.2, p < 0.001) to be independent risk factors influencing mortality. This analysis presents a work-through of all patients with stentless bioroot treatment without positive selection in a high-volume clinical center with the largest experience world-wide for this form of complex surgery. Isolated aortic root replacement could be performed at acceptable operative risk for this technically-challenging procedure.
Analysis of repetitive element expression in the blood and skin of patients with Parkinson’s disease identifies differential expression of satellite elements
Authors: Billingsley Kimberley J. , Lättekivi Freddy , Planken Anu , Reimann Ene , Kurvits Lille , Kadastik-Eerme Liis , Kasterpalu Kristjan M. , Bubb Vivien J. , Quinn John P. , Kõks Sulev , Taba Pille 
Published: March 2019

AbstractRepetitive elements (RE) constitute the majority of the human genome and have a range of functions both structural and regulatory on genomic function and gene expression. RE overexpression has been observed in several neurodegenerative diseases, consistent with the observation of aberrant expression of RE posing a mutagenic threat. Despite reports that associate RE expression with PD no study has comprehensively analysed the role of these elements in the disease. This study presents the first genome-wide analysis of RE expression in PD to date. Analysis of RNA-sequencing data of 12 PD patients and 12 healthy controls identified tissue-specific expression differences and more significantly, differential expression of four satellite elements; two simple satellite III (repName = CATTC_n and _GAATG_n) a high-copy satellite II (HSATII) and a centromeric satellite (ALR_Alpha) in the blood of PD patients. In support of the growing body of recent evidence associating REs with neurodegenerative disease, this study highlights the potential importance of characterization of RE expression in such diseases.