bluuebunny/crossref_metadata_2025_split huggingface dataset:
Key aroma compounds in Chinese fried food of youtiao
Authors: Du Wenbin , Zhao Mengyao , Zhen Dawei , Tan Jia , Wang Tianze , Xie Jianchun 
Published: October 2019

AbstractKey aroma compounds in Chinese popular fried food of youtiao were characterized by solvent assisted flavor evaporation combined with gas chromatography‐mass spectrometry (GC‐MS) and aroma extract dilution analysis of gas chromatography‐olfactometry (AEDA/GC‐O), quantitation, and aroma recombination and omission. Four samples of youtiao fried with sunflower oil, soybean oil, rapeseed oil, and palm oil, respectively, differing in fatty acid composition, were selected to be investigated. A total of thirty‐five odorants were identified, among which twenty‐two odorants were quantitated by aid of authentic chemicals and with correction of recovery coefficients. Differences in odorants composition and aroma profile were observed among the four samples of youtiao fried with different oils. However, it was demonstrated in common thirteen compounds; that is, 3‐hydroxy‐2‐butanone, 3‐methylbutanal, furfural, 3‐(methylthio)propanal, 2‐furfurylthiol, phenylacetaldehyde, 2,5‐dimethyl‐4‐hydroxy‐3(2H)‐furanone, 2‐ethyl‐3,5‐dimethylpyrazine, 3‐ethyl‐2,5‐dimethylpyrazine, (E,E)‐2,4‐decadienal, 1‐octen‐3‐ol, (E,Z)‐2,6‐nonadienal, and (E)‐2‐nonenal contributed significantly to youtiao aroma. The work can provide some guidance to maintain the preferred youtiao flavor when modifying its preparation technology for safety concerns.
qFIBS: An Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients With Nonalcoholic Steatohepatitis
Authors: Liu Feng , Goh George Boon‐Bee , Tiniakos Dina , Wee Aileen , Leow Wei‐Qiang , Zhao Jing‐Min , Rao Hui‐Ying , Wang Xiao‐Xiao , Wang Qin , Wan Wei‐Keat , Lim Kiat‐Hon , Romero‐Gomez Manuel , Petta Salvatore , Bugianesi Elisabetta , Tan Chee‐Kiat , Harrison Stephen A. , Anstee Quentin M. , Chang Pik‐Eu Jason , Wei Lai 
Published: October 2019

Background and Aims
Nonalcoholic steatohepatitis (NASH) is a common cause of chronic liver disease. Clinical trials use the NASH Clinical Research Network (CRN) system for semiquantitative histological assessment of disease severity. Interobserver variability may hamper histological assessment, and diagnostic consensus is not always achieved. We evaluate a second harmonic generation/two‐photon excitation fluorescence (SHG/TPEF) imaging‐based tool to provide an automated quantitative assessment of histological features pertinent to NASH.

Approach and Results
Images were acquired by SHG/TPEF from 219 nonalcoholic fatty liver disease (NAFLD)/NASH liver biopsy samples from seven centers in Asia and Europe. These were used to develop and validate qFIBS, a computational algorithm that quantifies key histological features of NASH. qFIBS was developed based on in silico analysis of selected signature parameters for four cardinal histopathological features, that is, fibrosis (qFibrosis), inflammation (qInflammation), hepatocyte ballooning (qBallooning), and steatosis (qSteatosis), treating each as a continuous rather than categorical variable. Automated qFIBS analysis outputs showed strong correlation with each respective component of the NASH CRN scoring (P < 0.001; qFibrosis [r = 0.776], qInflammation [r = 0.557], qBallooning [r = 0.533], and qSteatosis [r = 0.802]) and high area under the receiver operating characteristic curve values (qFibrosis [0.870‐0.951; 95% confidence interval {CI}, 0.787‐1.000; P < 0.001], qInflammation [0.820‐0.838; 95% CI, 0.726‐0.933; P < 0.001), qBallooning [0.813‐0.844; 95% CI, 0.708‐0.957; P < 0.001], and qSteatosis [0.939‐0.986; 95% CI, 0.867‐1.000; P < 0.001]) and was able to distinguish differing grades/stages of histological disease. Performance of qFIBS was best when assessing degree of steatosis and fibrosis, but performed less well when distinguishing severe inflammation and higher ballooning grades.

Conclusions
qFIBS is an automated tool that accurately quantifies the critical components of NASH histological assessment. It offers a tool that could potentially aid reproducibility and standardization of liver biopsy assessments required for NASH therapeutic clinical trials.
Transient electromagnetohydrodynamic radiative squeezing flow between two parallel Riga plates using a spectral local linearization approach
Authors: Thumma Thirupathi , Magagula Vusi Mpendulo 
Published: October 2019

AbstractThis article addresses transient electromagnetohydrodynamic radiative squeezing flow due to convectively heated electromagnetic actuator. The transport analysis of heat and mass is explored considering the heat generation/absorption and destructive species homogeneous reaction. Suitable transformations are applied on the mathematical model developed to convert governing partial differential equations to ordinary differential equations (ODEs). Spectral local linearization method (SLLM) is employed on the resultant nonlinear coupled ODEs to compute the numerical results. Influence of sundry physical quantities on heat mass transfer of squeezing flow characteristics are determined using graphs and tabular results. SLLM results exhibit that momentum and temperature improved with rise in squeezing and heat source parameters correspondingly. Momentum enhances at lower plate and detracts with rise in modified Hartmann number. For improved heat source parameter, the rate of heat transfer diminishes and is more significant for higher Prandtl number values. This investigation has relevance in disk style magnetic clutches, rolling elements, food processing, bearings, squeezing film pressure sensors, and flow rheostats.
The therapeutic effects of edaravone on collagen‐induced arthritis in rats
Authors: Zhang Xiaohan , Ye Guihong , Wu Zhengyuan , Zou Kai , He Xiaohong , Xu Xiaoqing , Yao Jun , Wei Qingjun 
Published: October 2019

AbstractCurrent research suggests that synovial phagocytic cells remove excessive amounts of free oxygen radicals (reactive oxygen species [ROS]), thereby preventing damage to synovial tissues. Moreover, ROS may affect the expression of growth arrest and DNA damage inducible α (GADD45A), thus further promoting the activation of synovial fibroblasts. Male adult rats were assessed for progression of collagen‐induced arthritis (CIA) using a macroscopic arthritis scoring system of the hind paws and by measuring the changes in the rat's body weight, and activity level before and after diagnosis of CIA. Rats were intraperitoneally injected twice daily with edaravone at doses of 3, 6, and 9 mL/kg. Samples were taken at 2, 4, and 6 weeks, respectively. Edaravone was found to significantly reduce macroscopic arthritis and microscopic pathology scores in CIA rats. The concentration of endothelial nitric oxide synthase‐6, glutathione, and heme oxygenase‐1 in the serum of rats decreased, as was the production of ROS around the synovium and inflammatory factors. Moreover, ROS‐1 increased the expression of the nuclear factor‐κB (NF‐κB) p65 protein by altering the expression level of GADD45A, causing aggravation of tissue damage. Edaravone also significantly improved the physiological condition of CIA rats, including appetite, weight changes, and loss of fur, as well as limb mobility. We believe that edaravone acts to reduce the expression of NF‐ĸB p65 by clearing ROS, which causes reduced expression of GADD45A, and subsequently reduces the level of apoptosis and inflammatory response proteins, thereby reducing the symptoms of CIA. We, therefore, propose that edaravone is an effective option for clinical treatment of rheumatic arthritis.
Androgen receptor‐related micro RNAs in prostate cancer and their role in antiandrogen drug resistance
Authors: Rezaei Samaneh , Mahjoubin Tehran Maryam , Sahebkar Amirhossein , Jalili Amin , Aghaee‐Bakhtiari Seyed Hamid 
Published: October 2019

AbstractProstate cancer (PCa) is one of the most common cancers and the fifth most common reason for cancer deaths in the males. Surgical castration combined with androgen deprivation therapy, antiandrogens, and androgen synthesis inhibitors is the current therapeutic modalities for PCa. These strategies inhibit androgen synthesis or reduce its binding to the androgen receptor (AR) but the development of resistance to these therapies and transient responsiveness are challenging issues in the treatment of this cancer. Deregulation of ARs has a vital role in the initiation and progression of PCa. Also, recent findings imply that micro RNAs (miRNAs) are involved in the evolution of PCa and mediate drug resistance in different cancers. Hence, discovering and targeting miRNAs might represent a novel therapeutic approach. This review paid particular attention to the AR pathway and existing information on the possible roles of miRNAs associated with AR pathway and drug resistance to two second‐generation antiandrogens, that is, enzalutamide and abiraterone.
Descriptive epidemiology of rubella disease and associated virus strains in Uganda
Authors: Tushabe Phionah , Bwogi Josephine , Abernathy Emily , Birungi Molly , Eliku James P. , Seguya Ronald , Bukenya Henry , Namuwulya Prossy , Kakooza Proscovia , Suppiah Suganthi , Kabaliisa Theopista , Tibanagwa Mayi , Ampaire Immaculate , Kisakye Annet , Bakainaga Andrew , Byabamazima Charles R. , Icenogle Joseph P. , Bakamutumaho Barnabas 
Published: October 2019

AbstractRubella virus causes a mild disease; however, infection during the first trimester of pregnancy may lead to congenital rubella syndrome (CRS) in over 80% of affected pregnancies. Vaccination is recommended and has been shown to effectively reduce CRS incidence. Uganda plans to introduce routine rubella vaccination in 2019. The World Health Organization recommends assessing the disease burden and obtaining the baseline molecular virological data before vaccine introduction. Sera collected during case‐based measles surveillance from January 2005 to July 2018 were tested for rubella immunoglobulin M (IgM) antibodies. Sera from confirmed rubella outbreaks from January 2012 to August 2017 were screened using real‐time reverse‐transcription polymerase chain reaction (RT‐PCR); for positive samples, a region within the E1 glycoprotein coding region was amplified and sequenced. Of the 23 196 suspected measles cases serologically tested in parallel for measles and rubella, 5334 (23%) were rubella IgM‐positive of which 2710 (50.8%) cases were females with 2609 (96.3%) below 15 years of age. Rubella IgM‐positive cases were distributed throughout the country and the highest number was detected in April, August, and November. Eighteen (18%) of the 100 sera screened were real‐time RT‐PCR‐positive of which eight (44.4%) were successfully sequenced and genotypes 1G and 2B were identified. This study reports on the seroprevalence and molecular epidemiology of rubella. Increased knowledge of former and current rubella viruses circulating in Uganda will enhance efforts to monitor the impact of vaccination as Uganda moves toward control and elimination of rubella and CRS.
From efficiency‐driven to low‐carbon operations management: Implications for labor productivity
Authors: Sartal Antonio , Rodríguez Miguel , Vázquez Xosé H. 
Published: October 2019

AbstractWe use 9 years of dynamic panel data (4,090 observations) to explore how decarbonization moderates the association between a selection of efficiency‐driven shop‐floor initiatives and labor productivity. The results are mixed: the relationship between materials efficiency and labor productivity is positively moderated by decarbonization, but the relationship between increases in inventory turnover or the average firm wage as a multiple of average sector wages are negatively moderated by decarbonization. Overall, we find that decarbonization leads to an average drop in sales of 1.8% per worker. This evidence therefore suggests that climate change goals impacting industrial firms might be difficult to accomplish if managers expect to achieve decarbonization for free with current organizational best practices.
In vivo safety assessment of Lactobacillus fermentum strains, evaluation of their cholesterol‐lowering ability and intestinal microbial modulation
Authors: Thumu Surya Chandra Rao , Halami Prakash M 
Published: October 2019

AbstractBACKGROUNDDespite the growing importance of probiotics apparent health benefits, an impediment to the use of new probiotic cultures is their safety. Hence there is a need to strictly examine the biosafety as well as health benefits of probiotics in in vivo model systems.RESULTSIn this study, two lactic acid bacterial (LAB) cultures Lactobacillus fermentum NCMR 2826 and FIX proven for their in vitro probiotic properties were investigated for their in vivo safety in Wistar rats. An acute toxicity study (14 days) with a high dose of biomass (1016 colony‐forming units (CFU) mL−1) followed by a subchronic test for 13 weeks with oral feeding of the probiotic cultures in three different doses (107, 108 and 1010 CFU mL−1) on a daily basis revealed the safety of the L. fermentum cultures. The probiotic feeding had no toxic effects on survival, body weight and food consumption with any of the dosages used throughout the treatment period. No statistically significant changes in relative organ weights and serum biochemical and hematological indices were found between the control and the probiotic fed animals. In addition to the safety attributes, the L. fermentum culture fed rats showed reduced serum cholesterol levels, macrovesicular steatosis and hepatocyte ballooning compared with control animals. Further, quantification of intestinal microbiota using real‐time polymerase chain reaction (PCR) analysis from animal feces indicated a significant increase and stability of Lactobacillus and Bifidobacterium counts but a decrease of Escherichia coli numbers.CONCLUSIONThis study of safety and beneficial features highlights the use of the two native L. fermentum isolates as potential probiotic food supplements. © 2019 Society of Chemical Industry
Sound waves affect the total flavonoid contents in Medicago sativa, Brassica oleracea and Raphanus sativus sprouts
Authors: Kim Joo Yeol , Kang Ye Eun , Lee Soo In , Kim Jin A , Muthusamy Muthusamy , Jeong Mi‐Jeong 
Published: October 2019

AbstractBACKGROUNDSound waves are emerging as a potential biophysical alternative to traditional methods for enhancing plant growth and phytochemical contents. However, little information is available on the improvement of the concentration of functional metabolites like flavonoids in sprouts using sound waves. In this study, different frequencies of sound waves with short and long exposure times were applied to three important varieties to improve flavonoid content. The aim of this study was to investigate the effect of sound waves on flavonoid content on the basis of biochemical and molecular characteristics.RESULTSWe examined the effects of various sound wave treatments (250 Hz to 1.5 kHz) on flavonoid production in alfalfa (Medicago sativa), broccoli (Brassica oleracea) and red young radish (Raphanus sativus). The results showed that sound wave treatments differentially altered the total flavonoid contents depending upon the growth stages, species and frequency of and exposure time to sound waves. Sound wave treatments of alfalfa (250 Hz), broccoli sprouts (800 Hz) and red young radish sprouts (1 kHz) increased the total flavonoid content by 200%, 35% and 85%, respectively, in comparison with untreated control. Molecular analysis showed that sound waves induce the expression of genes of the flavonoid biosynthesis pathway, which positively corresponds to the flavonoid content. Moreover, the sound wave treatment significantly improves the antioxidant efficiency of sprouts.CONCLUSIONSThe significant improvement of flavonoid content in sprouts with sound waves makes their use a potential and promising technology for the production of agriculture‐based functional foods. © 2019 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Determination of the Binding Situation of Pyridine in Xylan Sulfates by Means of Detailed NMR Studies
Authors: Gabriel Lars , Günther Wolfgang , Pielenz Friederike , Heinze Thomas 
Published: October 2019

AbstractXylan sulfate is an important drug to treat interstitial cystitis. Production of the drug by sulfation of the polysaccharide with a sulfating agent like chlorosulfuric acid and pyridine–SO3 complex in pyridine may lead to products containing pyridine‐based impurities. Xylan sulfate containing nitrogen is investigated by different NMR measurements in order to clarify the binding situation of pyridine. The detailed NMR studies allow the conclusion that the pyridine‐based impurities are covalently bonded to the reducing end group. Furthermore, the NMR spectroscopic investigation indicates that the side reactions occur at shorter polymer chains only.
Comparing variational methods for the hinged Kirchhoff plate with corners
Authors: De Coster Colette , Nicaise Serge , Sweers Guido 
Published: October 2019

AbstractThe hinged Kirchhoff plate model contains a fourth order elliptic differential equation complemented with a zeroeth and a second order boundary condition. On domains with boundaries having corners the strong setting is not well‐defined. We here allow boundaries consisting of piecewise C2, 1‐curves connecting at corners. For such domains different variational settings will be discussed and compared. As was observed in the so‐called Saponzhyan–Babushka paradox, domains with reentrant corners need special care. In that case, a variational setting that corresponds to a second order system needs an augmented solution space in order to find a solution in the appropriate Sobolev‐type space.
A gold mine for drug discovery: Strategies to develop cyclic peptides into therapies
Authors: Jing Xiaoshu , Jin Kang 
Published: October 2019

AbstractAs a versatile therapeutic modality, peptides attract much attention because of their great binding affinity, low toxicity, and the capability of targeting traditionally “undruggable” protein surfaces. However, the deficiency of cell permeability and metabolic stability always limits the success of in vitro bioactive peptides as drug candidates. Peptide macrocyclization is one of the most established strategies to overcome these limitations. Over the past decades, more than 40 cyclic peptide drugs have been clinically approved, the vast majority of which are derived from natural products. The de novo discovered cyclic peptides on the basis of rational design and in vitro evolution, have also enabled the binding with targets for which nature provides no solutions. The current review summarizes different classes of cyclic peptides with diverse biological activities, and presents an overview of various approaches to develop cyclic peptide‐based drug candidates, drawing upon series of examples to illustrate each strategy.
Mitigating inherent noise in Monte Carlo dose distributions using dilated U‐Net
Authors: Javaid Umair , Souris Kevin , Dasnoy Damien , Huang Sheng , Lee John A. 
Published: October 2019

PurposeMonte Carlo (MC) algorithms offer accurate modeling of dose calculation by simulating the transport and interactions of many particles through the patient geometry. However, given their random nature, the resulting dose distributions have statistical uncertainty (noise), which prevents making reliable clinical decisions. This issue is partly addressable using a huge number of simulated particles but is computationally expensive as it results in significantly greater computation times. Therefore, there is a trade‐off between the computation time and the noise level in MC dose maps. In this work, we address the mitigation of noise inherent to MC dose distributions using dilated U‐Net — an encoder–decoder‐styled fully convolutional neural network, which allows fast and fully automated denoising of whole‐volume dose maps.MethodsWe use mean squared error (MSE) as loss function to train the model, where training is done in 2D and 2.5D settings by considering a number of adjacent slices. Our model is trained on proton therapy MC dose distributions of different tumor sites (brain, head and neck, liver, lungs, and prostate) acquired from 35 patients. We provide the network with input MC dose distributions simulated using particles while keeping particles as reference.ResultsAfter training, our model successfully denoises new MC dose maps. On average (averaged over five patients with different tumor sites), our model recovers of 55.99 Gy from the noisy MC input of 49.51 Gy, whereas the low noise MC (reference) offers 56.03 Gy. We observed a significant reduction in average RMSE (thresholded >10% max ref) for reference vs denoised (1.25 Gy) than reference vs input (16.96 Gy) leading to an improvement in signal‐to‐noise ratio (ISNR) by 18.06 dB. Moreover, the inference time of our model for a dose distribution is less than 10 s vs 100 min (MC simulation using particles).ConclusionsWe propose an end‐to‐end fully convolutional network that can denoise Monte Carlo dose distributions. The networks provide comparable qualitative and quantitative results as the MC dose distribution simulated with particles, offering a significant reduction in computation time.
Complexity of inventory routing problems when routing is easy
Authors: Baller Annelieke C. , van Ee Martijn , Hoogeboom Maaike , Stougie Leen 
Published: October 2019

AbstractIn the inventory routing problem (IRP) inventory management and route optimization are combined. The traveling salesman problem (TSP) is a special case of the IRP, hence the IRP is NP‐hard. We investigate how other aspects than routing influence the complexity of a variant of the IRP. We first study problem variants on a point and on the half‐line. The problems differ in the number of vehicles, the number of days in the planning horizon and the service times of the customers. Our main result is a polynomial time dynamic programming algorithm for the variant on the half‐line with uniform service times and a planning horizon of 2 days. Second, for nearly any problem in the class with nonfixed planning horizon, we show that the complexity is dictated by the complexity of the pinwheel scheduling problem, for which the complexity is a long‐standing open research question. Third, NP‐hardness is shown for problem variants with nonuniform servicing times. Finally, we prove strong NP‐hardness of a Euclidean variant with uniform service times and an easily computable routing cost approximation, avoiding immediate NP‐hardness via the TSP.