bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract C40: Employment participation after early-stage breast cancer: Patterns and determinants
Authors: Ekenga Christine C. , Perez Maria , Margenthaler Julie A. , Jeffe Donna B. 
Published: February 2019

Abstract
Background: Employment is a social determinant of health. However, few longitudinal studies have examined employment outcomes in women with early-stage breast cancer. The purpose of this study was to examine employment trajectories in a cohort of early-stage breast cancer patients from treatment to 2-year follow-up, and evaluate relationships between sociodemographic, clinical/treatment, and psychosocial factors and employment outcomes.
Methods: Data from a cohort study of newly diagnosed early-stage breast cancer patients were used to examine employment outcomes among 347 working-age patients, 40-64 years old. We examined patients' employment trajectories after definitive surgical treatment, using a multivariable logistic regression model to identify factors associated with diminished (versus sustained) employment at 2-year follow-up.
Results: A total of 245 patients (71%) were employed at least part-time at the time of definitive surgical treatment. 50 patients (20%) reported diminished employment over the 2-year follow-up period. After adjusting for covariates (age, marital status, education, household income, insurance status, depression history, social support, comorbidity, and surgery alone or surgery with chemotherapy, radiation therapy, or both), we observed that fatigue, assessed as SF-36 vitality subscale score below the median (OR=5.50, 95%CI=2.41, 12.56), and African-American race (versus white race, OR=4.23, 95%CI=1.66, 10.76) were associated with diminished employment.
Conclusions: Patients with elevated fatigue and African Americans patients were more likely to experience diminished employment participation after definitive surgical treatment. Further research is warranted to identify factors associated with these disparities and strategies to improve workforce participation after breast cancer.
Citation Format: Christine C. Ekenga, Maria Perez, Julie A. Margenthaler, Donna B. Jeffe. Employment participation after early-stage breast cancer: Patterns and determinants [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr C40.
Abstract C56: An online-based storytelling video intervention on promoting Korean American female college students' HPV vaccine uptake
Authors: Kim Minjin , Lee Haeok , Aronowitz Teri , Sheldon Lisa Kennedy , Kiang Peter , Allison Jeroan , Shi Ling 
Published: February 2019

Abstract
Introduction: Korean American (KA) women are at high risk for human papillomavirus (HPV) infection and cervical cancer, yet they have low awareness and knowledge about HPV vaccine, and subsequently have low HPV vaccine uptake rates. Therefore, it is imperative to develop culturally appropriate education interventions to reduce the health disparities.
Objective: This study aimed to evaluate the effects of an online storytelling intervention to promote HPV vaccine uptake by conducting a pilot randomized controlled trial (RCT).
Method: We recruited 104 participants from multiple sites in six different states in Northeast.
Participants were eligible if they were current KA female college students between the ages of 18-26 and who have not been vaccinated for HPV. This study was implemented in an innovative online laboratory from data collection to experimentation. Participants were randomly assigned to the experimental group (a storytelling video) or control group (written information). The effects of the intervention were assessed at post-intervention and 2-month follow-up.
Results: Both experimental group and control group improved in knowledge and attitudes from baseline to post-intervention. However, the experimental group had higher overall knowledge score, satisfaction with the education program, and intention to get the HPV vaccine within 1 year and was twice as likely to receive or schedule an appointment for the HPV vaccine compared with the control group (15.6% vs. 7.1%).
Conclusion: This pilot study provides evidence in support of the effectiveness of the storytelling video intervention in using an innovative online laboratory setting aimed at HPV and HPV-related cancer prevention.
Citation Format: Minjin Kim, Haeok Lee, Teri Aronowitz, Lisa Kennedy Sheldon, Peter Kiang, Jeroan Allison, Ling Shi. An online-based storytelling video intervention on promoting Korean American female college students' HPV vaccine uptake [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr C56.
Abstract IA03: Breast cancer disparities: Progress, challenges, and opportunities
Authors: Li Christopher I. 
Published: February 2019

Abstract
Breast cancer remains the most commonly diagnosed cancer among women in the United States and worldwide. Important disparities in breast cancer incidence and mortality persist. African American, Hispanic, and American Indian/Alaska Native women are more commonly diagnosed with aggressive forms of breast cancer (including advanced stage disease and triple-negative breast cancer) and experience lower 5-year survival rates. While survival rates have improved across all races/ethnicities, the disparity gap between different races/ethnicities has held essentially constant. Underlying these disparities are a host of factors related to access to care, socioeconomic status, lifestyle/cultural factors, and systems-level factors. For example, mammography utilization varies considerably by education and insurance status, and African American and Hispanic women are less like to receive guideline-concordant treatment for their breast cancers compared to non-Hispanic whites. Additionally, several risk factors that are more common among African American and Hispanic women (including parity, early age at first pregnancy, and obesity) have been shown to be associated with risk of triple-negative breast cancer, potentially accounting for the greater frequency of this aggressive subtype that they experience. Contributors to breast cancer disparities occur on multiple levels and span the entire breast cancer continuum from prevention to screening to diagnosis/treatment and to survivorship. Continued research on all fronts is necessary to address these persistent disparities.
Citation Format: Christopher I. Li. Breast cancer disparities: Progress, challenges, and opportunities [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr IA03.
Abstract IA14: Not the same everywhere: The moderating role of context on cancer disparities
Authors: Pruitt Sandi L. 
Published: February 2019

Abstract
In the emerging field of multilevel cancer disparities research, investigators typically examine the independent contribution of factors such as individual- and neighborhood-level race/ethnicity and socioeconomic status. The moderating role of context is often neglected. In the real world, people interact with and are nested within multiple contexts that may influence the processes whereby disparities are generated and reinforced. The moderating role of context will be explored using two illustrative examples drawn from colorectal cancer screening and breast cancer mortality. Specific contexts explored include patient residence, neighborhood, health care system, and state. In the first example, expected patterns of individual- and neighborhood- level disparity were not evident in colorectal cancer screening among patients of an urban safety-net health care system. For example, neighborhood disparity was limited and the expected pattern of patient-level racial and ethnic disparity (i.e., advantage of white patients as compared to African American and Hispanic patients) was not observed. In the second example, differences in neighborhood context between Texas and California are explored in a study of breast cancer mortality. State-level differences in both neighborhood socioeconomic status and density of Hispanic residents are explored as potential moderators of the association between patient ethnicity, birthplace, and mortality. To conclude the discussion, contextual variables potentially influencing cancer behaviors and outcomes will be identified and described in regard to existing evidence about their influence, methods, and datasets for their analysis, and opportunities for future research.
Citation Format: Sandi L. Pruitt. Not the same everywhere: The moderating role of context on cancer disparities [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr IA14.
Abstract IA17: The tobacco environment at the point of sale and the effects on vulnerable populations
Authors: A Lourdes 
Published: February 2019

Abstract
This presentation will cover findings from a project in the tobacco retail environment of the Tobacco Center for Regulatory Sciences in Vulnerable Populations at USC. Qualitative and survey research was conducted among over 700 retailers and in retail outlets that sell tobacco products in vulnerable ethnic communities, including among American Indian tribal lands, in African American, Hispanic/Latino, Korean, and low-SES non-Hispanic White neighborhoods. Findings show violations to tobacco rulings as well as identify potential areas of concern and viable targeted and culturally tailored solutions to reducing exposure to environmental influences that foster and encourage the use of tobacco products in vulnerable communities.
Citation Format: Lourdes A. The tobacco environment at the point of sale and the effects on vulnerable populations [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr IA17.
Abstract IA25: Disparities in survivors of pediatric, adolescent, and young adult cancers
Authors: Bhatia Smita 
Published: February 2019

Abstract
Outcome disparities in pediatric, adolescent, and young adult cancer are multifaceted. While disparities are commonly described along racial/ethnic lines, the underlying causes of these differences in outcome are often rooted in socioeconomic status, host genetics, disease biology, health literacy lifestyle factors, health behaviors, and comorbidities. Nonetheless, by the middle of this century, racial/ethnic minority populations will collectively constitute 50% of the U.S. population. This temporal shift in the racial/ethnic composition of the U.S. population demands a close examination of the observed disparities in both the quality and quantity of survival in pediatric, adolescent, and young adult cancer. In this talk we describe the differences in overall and event-free survival by race/ethnicity as well as by age (children vs. adolescent and young adult) across a variety of cancer types. We examine the causes of the difference in these outcomes. We describe the burden of morbidity carried by cancer survivors across racial/ethnic and socioeconomic lines and present the current evidence for the causes of observed differences in morbidity. We speculate that any racial/ethnic differences in outcome are likely to be multifactorial, and draw on extant literature to illustrate the various contributors (socioeconomic characteristics, health behaviors, disease biology, and comorbidities) that could explain any observed differences in key treatment-related complications. Finally, we outline challenges in conducting race/ethnicity-specific survivorship research, demonstrating that there are limited absolute numbers who are diagnosed and survive histologically distinct cancers in any one racial/ethnic minority population, thereby precluding a rigorous evaluation of adverse events among specific primary cancer diagnoses and treatment exposure groups.
Citation Format: Smita Bhatia. Disparities in survivors of pediatric, adolescent, and young adult cancers [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr IA25.
Abstract IA32: Building and sustaining partnerships in cancer health disparities research
Authors: Halbert Chanita Hughes 
Published: February 2019

Abstract
Partnerships between academic institutions, public health agencies, and community-based organizations are critical to addressing racial and ethnic disparities in cancer outcomes. However, developing and sustaining these partnerships may be challenging because of differences in organizational missions, priorities, and infrastructure for conducting research. While these issues can be addressed by establishing a shared vision and mission for the partnership using principles of community-based participatory research, it is also critical to establish an effective administrative structure that centralizes and integrates activities across research and outreach efforts. This presentation will use two case examples of building and sustaining partnerships for cancer health disparities research. The first example is the process that was used to develop and manage the West Philadelphia Consortium to Address Disparities that was established to address minority health and health disparities in chronic diseases among African Americans in the Philadelphia, PA metropolitan area. The second example will focus on describing the Consortium Core that is a component of the Medical University of South Carolina Transdisciplinary Collaborative Center in Precision Medicine and Minority Men's Health.
Citation Format: Chanita Hughes Halbert. Building and sustaining partnerships in cancer health disparities research [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr IA32.
Plasminogen Activator Inhibitor 1 (PAI1) Promotes Actin Cytoskeleton Reorganization and Glycolytic Metabolism in Triple-Negative Breast Cancer
Authors: Humphries Brock A. , Buschhaus Johanna M. , Chen Yu-Chih , Haley Henry R. , Qyli Tonela , Chiang Benjamin , Shen Nathan , Rajendran Shrila , Cutter Alyssa , Cheng Yu-Heng , Chen Yu-Ting , Cong Jason , Spinosa Phillip C. , Yoon Euisik , Luker Kathryn E. , Luker Gary D. 
Published: February 2019

Abstract

Migration and invasion of cancer cells constitute fundamental processes in tumor progression and metastasis. Migratory cancer cells commonly upregulate expression of plasminogen activator inhibitor 1 (PAI1), and PAI1 correlates with poor prognosis in breast cancer. However, mechanisms by which PAI1 promotes migration of cancer cells remain incompletely defined. Here we show that increased PAI1 drives rearrangement of the actin cytoskeleton, mitochondrial fragmentation, and glycolytic metabolism in triple-negative breast cancer (TNBC) cells. In two-dimensional environments, both stable expression of PAI1 and treatment with recombinant PAI1 increased migration, which could be blocked with the specific inhibitor tiplaxtinin. PAI1 also promoted invasion into the extracellular matrix from coculture spheroids with human mammary fibroblasts in fibrin gels. Elevated cellular PAI1 enhanced cytoskeletal features associated with migration, actin-rich migratory structures, and reduced actin stress fibers. In orthotopic tumor xenografts, we discovered that TNBC cells with elevated PAI1 show collagen fibers aligned perpendicular to the tumor margin, an established marker of invasive breast tumors. Further studies revealed that PAI1 activates ERK signaling, a central regulator of motility, and promotes mitochondrial fragmentation. Consistent with known effects of mitochondrial fragmentation on metabolism, fluorescence lifetime imaging microscopy of endogenous NADH showed that PAI1 promotes glycolysis in cell-based assays, orthotopic tumor xenografts, and lung metastases. Together, these data demonstrate for the first time that PAI1 regulates cancer cell metabolism and suggest targeting metabolism to block motility and tumor progression.

Implications:
We identified a novel mechanism through which cancer cells alter their metabolism to promote tumor progression.
Abstract A06: LINC00261 acts as a tumor suppressor in lung adenocarcinoma
Authors: Castillo Jonathan , Shahabi Shandy , Kumaran Vishaly , Marconett Crystal 
Published: February 2019

Abstract
Lung cancer is the leading cause of cancer-related mortality, with a 5-year mortality rate approaching 85%. My lab focuses on the major histologic subtype, lung adenocarcinoma (LUAD). Using a combination of bioinformatics and biologic analyses, we have uncovered a role for novel regulatory RNAs in the etiology of LUAD development. Our current research focuses primarily on a long noncoding RNA with effects on proliferation and metastasis of lung cancer cells. It is our hope to identity key regulators of cancer development and progression, so that targeted therapeutics can be developed to help improve the overall survival rate for this deadly disease.
Citation Format: Jonathan Castillo, Shandy Shahabi, Vishaly Kumaran, Crystal Marconett. LINC00261 acts as a tumor suppressor in lung adenocarcinoma [abstract]. In: Proceedings of the Fifth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic; Jan 8-11, 2018; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2018;24(17_Suppl):Abstract nr A06.
Abstract A37: Tobacco smoke increases lung adenocarcinoma risk by downregulating TGF-beta and AhR-regulated focal adhesion proteins involved in injury resolution
Authors: Stueve Theresa Ryan , Yang Chenchen , Marconett Crystal N. , Yan Chunli , Zhou Beiyun , Borok Zea , Laird-Offringa Ite A. 
Published: February 2019

Abstract
Background: The most prevalent type of lung cancer—lung adenocarcinoma—arises from the most distal reaches of the lung in the alveolar epithelium. The alveolar epithelium consists of two cell types: (i) thin type I alveolar epithelial cells (AT1) that facilitate gas exchange and constitute more than 90% of the alveolar surface, and (ii) cuboidal surfactant-producing type II (AT2) cells. Following injury, dynamic interactions between extracellular matrix components, integrins, focal adhesion proteins, and cytoskeletal components allow AT2 progenitor cells to migrate, spread, and transdifferentiate into AT1 cells to restore the denuded epithelial barrier.
Methods: Utilizing primary human AT2 cells isolated from lung transplant remnants, our lab has established and extensively profiled an in vitro model of epithelial restitution, wherein AT2 cells differentiate over a period of six days into terminally differentiated AT1-like cells. Because cigarette smoking is the most recognized risk factor for lung adenocarcinoma (LUAD), and because the alveolar space is the primary target of tobacco smoke, we also compared the RNA-seq profiles of AT2&gt;AT1 differentiation to those of A549 LUAD cells exposed to cigarette smoke condensate (CSC).
Results: We find that CSC downregulates many factors that are upregulated in the AT2&gt;AT1 restitution model, particularly integrins, extracellular matrix components, and novel focal adhesion proteins that are also downregulated in LUAD relative to adjacent normal tissue. We describe regulation of four such novel focal adhesion proteins, specifically by TGF-β and aryl hydrocarbon receptor (AhR)-mediated mechanisms.
Conclusions: Our findings shed light on early mechanisms in the carcinogenic process, and support the notion that alveolar cells engaged in repeated cycles of injury and repair are critical actors in LUAD risk trajectories.
Note: This abstract was not presented at the conference.
Citation Format: Theresa Ryan Stueve, Chenchen Yang, Crystal N. Marconett, Chunli Yan, Beiyun Zhou, Zea Borok, Ite A. Laird-Offringa. Tobacco smoke increases lung adenocarcinoma risk by downregulating TGF-beta and AhR-regulated focal adhesion proteins involved in injury resolution [abstract]. In: Proceedings of the Fifth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic; Jan 8-11, 2018; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2018;24(17_Suppl):Abstract nr A37.
Abstract B13: The impact of combined CDK9 inhibition and TRAIL treatment on NSCLC
Authors: Zubiaur Itziar Areso , Montinaro Antonella , Karstedt Silvia von , Lemke Johannes , Hartwig Torsten , Taraborelli Lucia , Surinova Silvia , El-Bahrawy Mona A. , Walczak Henning 
Published: February 2019

Abstract
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has been shown to specifically kill cancer cells in vivo. On the basis of this, TRAIL-receptor (TRAIL-R) agonists were devised for clinical use. However, to date, TRAIL-R agonists have only shown limited therapeutic benefit in clinical trials. This can most likely be attributed to the fact that most primary human cancers are TRAIL resistant. It is therefore important to identify potent and cancer-selective TRAIL-sensitizers that overcome TRAIL resistance. Recently, the combination of CDK9 inhibition with TRAIL was found to effectively induce apoptosis in a panel of TRAIL-resistant non-small cell lung cancer (NSCLC) cell lines. Furthermore, tumors from NSCLC patients show high expression levels of CDK9, providing a rationale for targeting CDK9 in lung cancer. Here, we evaluate how effective the new TRAIL/CDK9 inhibition combination therapy is in treating lung cancer in an autochthonous mouse model (the KrasG12D/p53R172H) that closely recapitulates the human disease. We found that this combination was highly effective in vivo and led to a significant tumor regression and prolonged the survival of these mice. Our most recent results regarding these effects will be presented.
Citation Format: Itziar Areso Zubiaur, Antonella Montinaro, Silvia von Karstedt, Johannes Lemke, Torsten Hartwig, Lucia Taraborelli, Silvia Surinova, Mona A. El-Bahrawy, Henning Walczak. The impact of combined CDK9 inhibition and TRAIL treatment on NSCLC [abstract]. In: Proceedings of the Fifth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic; Jan 8-11, 2018; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2018;24(17_Suppl):Abstract nr B13.