bluuebunny/crossref_metadata_2025_split huggingface dataset:
Persistent and Chronic Postoperative Opioid Use in a Cohort of Patients with Oral Tongue Squamous Cell Carcinoma
Authors: Cata Juan P , Patino Miguel , Gorur Aysegul , Du Kim N , Uhelski Megan L , Myers Jeffrey , Lai Stephen , Rubin M Laura , Dougherty Patrick M , Owusu-Agyemang Pascal 
Published: August 2019

Abstract

Background
Recently, the concept of persistent postsurgical opioid use has been described for patients undergoing cancer surgery. Our hypothesis was based on the premise that patients with oral tongue cancer require high dosages of opioids before, during, and after surgery, and thus a large percentage of patients might develop persistent postsurgical opioid use.

Methods
After institutional review board approval, we conducted a retrospective study that included a cohort of patients with oral tongue cancers who underwent curative-intent surgery in our institution. Multivariable logistic regression models were fit to study the association of the characteristics of several patients with persistent (six months after surgery) and chronic (12 months after surgery) postoperative opioid use.

Results
A total of 362 patients with oral tongue malignancies were included in the study. The rate of persistent use of opioids after surgery was 31%. Multivariate analysis showed that patients taking opioids before surgery and those receiving adjuvant therapy were 2.9 and 1.78 times more likely to use opioids six months after surgery. Fifteen percent of the patients were taking opioids 12 months after surgery. After adjusting for clinically relevant covariates, patients complaining of moderate tongue pain before surgery and those taking opioids preoperatively had at least three times higher risk of still using these analgesics one year after surgery.

Conclusions
Patients with oral tongue cancers have a high risk of developing persistent and chronic postsurgical opioid use.
Continuum limit in numerical simulations of the $\mathcal{N}=2$ Landau–Ginzburg model
Authors: Morikawa Okuto 
Published: August 2019

Abstract
The $\mathcal{N}=2$ Landau–Ginzburg description provides a strongly interacting Lagrangian realization of an $\mathcal{N}=2$ superconformal field theory. It is conjectured that one such example is given by the two-dimensional $\mathcal{N}=2$ Wess–Zumino model. Recently, the conjectured correspondence has been studied by using numerical techniques based on lattice field theory; the scaling dimension and the central charge have been directly measured. We study a single superfield with a cubic superpotential, and give an extrapolation method to the continuum limit. Then, on the basis of a supersymmetric-invariant numerical algorithm, we perform a precision measurement of the scaling dimension through a finite-size scaling analysis.
Family-Centered Care Enhanced Neonatal Neurophysiological Function in Preterm Infants: Randomized Controlled Trial
Authors: Yu Yen-Ting , Huang Wan-Chi , Hsieh Wu-Shiun , Chang Jui-Hsing , Lin Chyi-Her , Hsieh Shulan , Lu Lu , Yao Nai-Jia , Fan Pi-Chuan , Lee Chia-Lin , Tu Yu-Kang , Jeng Suh-Fang 
Published: August 2019

Abstract

Background
Family-centered intervention for preterm infants has shown short- to medium-term developmental benefits; however, the neurological effects of intervention have rarely been explored.

Objective
The objectives of this study were to examine the effect of a family-centered intervention program (FCIP) on neurophysiological functions in preterm infants with very low birth weight (VLBW; birth weight of &lt; 1500 g) in Taiwan, to compare the effect of the FCIP with that of a usual-care program (UCP), and to explore the FCIP-induced changes in neurobehavioral and neurophysiological functions.

Design
This was a multicenter, single-blind randomized controlled trial.

Setting
The study took place in 3 medical centers in northern and southern Taiwan.

Participants
Two hundred fifty-one preterm infants with VLBW were included.

Intervention
The FCIP group received a family-centered intervention and the UCP group received standard care during hospitalization.

Measurements
Infants were assessed in terms of neurobehavioral performance using the Neonatal Neurobehavioral Examination–Chinese version, and their neurophysiological function was assessed using electroencephalography/event-related potentials during sleep and during an auditory oddball task during the neonatal period.

Results
The FCIP promoted more mature neurophysiological function than the UCP, including greater negative mean amplitudes of mismatch negativities in the left frontal region in the oddball task in all infants, lower intrahemispheric prefrontal-central coherence during sleep in infants who were small for gestational age, and higher interhemispheric frontal coherence during sleep in those who were appropriate for gestational age. Furthermore, interhemispheric coherence was positively associated with the total neurobehavioral score in preterm infants who were appropriate for gestational age (r = 0.20).

Limitations
The fact that more parental adherence strategies were used in the FCIP group than in the UCP group might have favored the intervention effect in this study.

Conclusions
Family-centered intervention facilitates short-term neurophysiological maturation in preterm infants with VLBW in Taiwan.
Predictors of Pelvic Floor Muscle Dysfunction Among Women With Lumbopelvic Pain
Authors: Keizer Alexzandra , Vandyken Brittany , Vandyken Carolyn , Yardley Darryl , Macedo Luciana , Kuspinar Ayse , Fagahani Nelly , Forget M-J , Dufour Sinéad 
Published: August 2019

Abstract

Background
There is evidence to suggest that a large proportion of individuals seeking care for lumbopelvic pain also have pelvic floor muscle dysfunction (PFMD). Because the majority of physical therapists do not have the requisite training to adequately assess pelvic floor musculature, determining predictors of PFMD could be clinically useful.

Objective
The objective was to establish a combination of factors (self-report and physical) predictive of PFMD in women with lumbopelvic pain.

Design
This was a cross-sectional study.

Methods
Participants completed a battery of self-report and physical assessments (masked assessors). Three clinical findings characterized PFMD: weakness of the pelvic floor, lack of coordination of the pelvic floor, and pelvic floor muscle tenderness on palpation (bilateral obturator internus). Univariate and multivariate logistic regression analyses were used to determine the extent to which different predictors were associated with PFMD.

Results
One hundred eight women with self-reported lumbopelvic pain (within the past week) were included in the study (mean age = 40.4 years; SD = 12.6 years). None of the examined factors predicted pelvic floor muscle weakness. Two factors independently predicted pelvic floor muscle tenderness on palpation: very strong and/or uncontrollable urinary urges (odds ratio [OR] = 2.93; 95% confidence interval [CI] = 1.13–7.59) and Central Sensitization Inventory scores of 40 or greater (OR = 3.13; 95% CI = 1.08–9.10).

Limitations
The sample consisted of young women, some of whom were not actively seeking care. Additionally, the technique for assessing pelvic floor muscle tenderness on palpation requires further validation.

Conclusions
Women who have lumbopelvic pain, uncontrollable urinary urgency, and central sensitization were, on average, 2 times more likely to test positive for pelvic floor muscle tenderness on palpation. Further studies are needed to validate and extend these findings.
The role of scientific reasoning and religious beliefs in use of complementary and alternative medicine
Authors: Čavojová Vladimíra , Ersoy Selin 
Published: August 2019

Abstract

Background
While previous research has shown that trust in complementary and alternative medicine (CAM) is linked with other unfounded beliefs (e.g. paranormal phenomena or pharmaceutical conspiracies) and that analytic thinking can help alter these beliefs, the role of the ability to evaluate evidence as a protective factor has not been established yet.

Methods
A cross-sectional design with a hundred participants was used with self-report data from questionnaires and performance test. The dependent variables were the belief in CAM and use of CAM. Predictor variables were scientific reasoning (measured by Scientific Reasoning Scale), critical thinking dispositions (measured by Critical Thinking Disposition Instrument; UF-EMI), religious beliefs (measured by Santa Clara Strength of Religious Faith Questionnaire), gender and age.

Results
Scientific reasoning and religious faith independently predicted belief in alternative medicine, while the role of scientific reasoning in actual reported use of CAM diminished after religious faith, gender and age were introduced to the model.

Conclusion
The results highlight the fact that it is not enough to appeal to the general critical thinking of people, but we need to teach them some practical skills that would help them to evaluate evidence in other, health-unrelated, contexts as well.
Lucy Hutchinson’s Theological Writings
Authors: Gribben Crawford 
Published: August 2019

Abstract
Lucy Hutchinson’s religious commitments inform her writing across its variety of genres. Critics and historians have tended to identify her as a Baptist, following the rejection of infant baptism that she records in her biography of her husband, John Hutchinson. But the recent publication of her theological writings allows for a more complicated account of her changing religious views. In the Life, Lucy Hutchinson showed how her husband’s theological commitments radicalized after the Restoration. His turn away from Protestant scholasticism towards a more independent engagement with the Bible facilitated his investigation of millennial theory. After his death, Lucy Hutchinson continued this autonomous theological exploration, and moved further from the orthodox mainstream. After the mid-1660s, she prepared a sequence of theological writings that evidence her increasingly eclectic religious style. These documents suggest that she did not resolve some of her most dramatic movements away from Reformed orthodoxy. In these writings, Hutchinson negotiated a critical distance from her husband’s legacy, the Reformed confessional tradition, and the options available in any of the available dissenting congregations.
Keep calm and carry on: electrophysiological evaluation of emotional anticipation in the second language
Authors: Jończyk Rafał , Korolczuk Inga , Balatsou Evangelia , Thierry Guillaume 
Published: August 2019

AbstractInvestigations of the so-called ‘foreign language effect’ have shown that emotional experience is language-dependent in bilingual individuals. Response to negative experiences, in particular, appears attenuated in the second language (L2). However, the human brain is not only reactive, but it also builds on past experiences to anticipate future events. Here, we investigated affective anticipation in immersed Polish–English bilinguals using a priming paradigm in which a verbal cue of controlled affective valence allowed making predictions about a subsequent picture target. As expected, native word cues with a negative valence increased the amplitude of the stimulus preceding negativity, an electrophysiological marker of affective anticipation, as compared with neutral ones. This effect was observed in Polish–English bilinguals and English monolinguals alike. The contrast was non-significant when Polish participants were tested in English, suggesting a possible reduction in affective sensitivity in L2. However, this reduction was not validated by a critical language × valence interaction in the bilingual group, possibly because they were highly fluent in English and because the affective stimuli used in the present study were particularly mild. These results, which are neither fully consistent nor inconsistent with the foreign language effect, provide initial insights into the electrophysiology of affective anticipation in bilingualism.
Increased neural reactivity to emotional pictures in men with high hair testosterone concentrations
Authors: Klein Sanja , Kruse Onno , Tapia León Isabell , Stalder Tobias , Stark Rudolf , Klucken Tim 
Published: August 2019

Abstract
Testosterone has been linked to alterations in the activity of emotion neurocircuitry including amygdala, orbitofrontal cortex (OFC) and insula and diminished functional amygdala/prefrontal coupling. Such associations have only ever been studied using acute measures of testosterone, thus little is known about respective relationships with long-term testosterone secretion. Here, we examine associations between hair testosterone concentration (HTC), an index of long-term cumulative testosterone levels and neural reactivity during an emotional passive viewing task using functional magnetic resonance imaging (fMRI). Forty-six men viewed negative, positive and neutral pictures in the MRI. HTCs were assessed from 2 cm hair segments. The emotional paradigm elicited neural activation in the amygdala, insula and OFC. HTCs were associated with increased reactivity to negative pictures in the insula and increased reactivity to positive pictures in the OFC. We show an association of long-term testosterone levels with increased emotional reactivity in the brain. These results suggest a heightened emotional vigilance in individuals with high trait testosterone levels.
Potato virus Y; the Andean connection
Authors: Fuentes Segundo , Jones Roger A C , Matsuoka Hiroki , Ohshima Kazusato , Kreuze Jan , Gibbs Adrian J 
Published: August 2019

AbstractPotato virus Y (PVY) causes disease in potatoes and other solanaceous crops. The appearance of its necrogenic strains in the 1980s made it the most economically important virus of potatoes. We report the isolation and genomic sequences of 32 Peruvian isolates of PVY which, together with 428 published PVY genomic sequences, gave an alignment of 460 sequences. Of these 190 (41%) were non-recombinant, and 162 of these provided a dated phylogeny, that corresponds well with the likely history of PVY, and show that PVY originated in South America which is where potatoes were first domesticated. The most basal divergences of the PVY population produced the N and C: O phylogroups; the origin of the N phylogroup is clearly Andean, but that of the O and C phylogroups is unknown, although they may have been first to establish in European crops. The current PVY population originated around 156 CE. PVY was probably first taken from South America to Europe in the 16th century in tubers. Most of the present PVY diversity emerged in the second half of the 19th century, after the Phytophthora infestans epidemics of the mid-19th century destroyed the European crop and stimulated potato breeding. Imported breeding lines were shared, and there was no quarantine. The early O population was joined later by N phylogroup isolates and their recombinants generated the R1 and R2 populations of damaging necrogenic strains. Our dating study has confirmed that human activity has dominated the phylodynamics of PVY for the last two millennia.
18Popular Culture
Authors: Potts Tracey 
Published: August 2019

AbstractThis year’s chapter explores themes of consumption, popular culture, and sustainability in publications from 2018. Starting with the biggest issue we face today—climate change—the aim is to survey and complicate the picture of the consumer and consumer culture by way of refusing some of the more glib accounts of over-consumption. The heavy lifting of the discussion is accomplished by an article that dissects recent scholarship around consumer practice and the environment. This article then forms a framework for looking at books on souvenirs, pop music heritage, digital music, and American popular culture, ending with a sustained look at the cultural anatomy of the hamburger.
Late Cretaceous (Maastrichtian) crocodyliforms from north-eastern Iberia: a first attempt to explain the crocodyliform diversity based on tooth qualitative traits
Authors: Blanco Alejandro , Puértolas-Pascual Eduardo , Marmi Josep , Moncunill-Solé Blanca , Llácer Sergio , Rössner Gertrud E 
Published: August 2019

Abstract
During recent years, knowledge about crocodyliform diversity of the uppermost Cretaceous from Europe has been substantially improved. Palaeontological efforts have also been focused on microvertebrate diversity and its palaeoecological implications. Isolated crocodylomorph teeth are, by far, one of the most frequently recovered elements in microvertebrate samples. In the present paper, morphological features of crocodylomorph teeth collected throughout the complete Maastrichtian series of the southern Pyrenean basin (north-eastern Spain), together with several mandibular remains, are described and analysed. Teeth were grouped in morphotypes and their taxonomic significance is discussed. The results highlight a diverse crocodylomorph assemblage in this area throughout the Maastrichtian. In addition, feeding habits and environmental preferences are inferred for the identified taxa according to dental features, occurrences and taphonomy.
A Novel Anatomic Landmark to Assess Adequate Decompression in Anterior Cervical Spine Surgery
Authors: Aleem Ilyas S. , Alder Jason , Popper Joseph , Freedman Brett , Nassr Ahmad , Bydon Mohamad , Yaszemski Michael J. , Currier Bradford L. 
Published: August 2019

Study Design:
A retrospective study.

Objectives:
(1) To assess the reliability of using the posterior endplate valley (PEV) to predict the cranial-caudal location of the cervical pedicle intraoperatively; (2) to assess the impact of age on the cervical PEV-pedicle relationship, interpedicular distance, and foraminal height.

Summary of Background Data:
The cervical pedicle, which is the anatomic landmark defining the boundaries of the foramen, is hidden from view intraoperatively in the anterior cervical approach, potentially leading to incomplete foraminal decompression. An intraoperative landmark which heralds the location of the pedicle and therefore can be relied upon as a guide for decompression has not been previously described.

Methods:
We retrospectively reviewed cervical computed tomography images of younger (<50 y) and older (>50 y) patients. Using the coronal reconstructed image taken at the posterior margin of the vertebral body, we constructed a line between the superior aspect of the pedicles and measured the distance from this line to the PEV. Interpedicular distance and foraminal height were also measured.

Results:
One hundred patients were included in the final analysis. The mean distance (mm) from the pedicular line to the PEV from C3 to C7 respectively was 1.0±0.99, 0.01±0.76, 0.09±0.70, 0.20±0.71, and 0.27±0.79. No significant difference between young and elderly patients was noted (P<0.05). Intervertebral foraminal size was significantly greater in younger compared with elderly patients at all levels except C2–C3. The mean interpedicular distance was 23.05±1.76 mm.

Conclusions:
This study demonstrates, for the first time, that the PEV is an accurate surgical landmark that is consistently at most 1 mm from the superior aspect of the cervical pedicle in the subaxial spine. Furthermore, this study demonstrated that foraminal height was significantly larger in younger compared with elderly patients at all cervical levels below C3.

Level of Evidence:
Level 3.
Spinal Epidural Venous Plexus Pathology in Hirayama Disease
Authors: Macey Mathew B. , Ho Doreen T. , Parres Christopher M. , Small Juan E. 
Published: August 2019

Abstract
Hirayama disease is a rare juvenile amyotrophy that is often misdiagnosed as an unrelated, relentlessly progressive disease. We present the case of an 18-year-old man who presented with weakness and atrophy of the right forearm and hand. Dynamic cervical magnetic resonance imaging was used, revealing the classic findings of epidural venous plexus dilation and anterior displacement of the dural sac. In addition, dilation of the external vertebral venous plexus was visualized. We discuss the clinical utility of dynamic magnetic resonance imaging and the underlying pathophysiology of these findings in Hirayama disease.
Phenotypic Differences in 2 Unrelated Cases Carrying Identical DOK7 Mutations
Authors: Bissay Véronique , Maselli Ricardo A. 
Published: August 2019

Abstract

Introduction:
Mutations in the Dok-7 gene (DOK7) underlie a congenital myasthenic syndrome (CMS) with a characteristic limb-girdle (LG) pattern of muscle weakness. Multiple clinical findings and a wide clinical heterogeneity have been identified in this form of CMS.

Methods:
We describe here 2 unrelated adult patients who presented with a LG CMS, caused by 2 compound heterozygous pathogenic sequence variants in DOK7: c.1124_1127dupTGCC (P.Ala378Serfs*30) and c.480C> A (p.Tyr160*).

Results:
Although both patients presented with severe proximal weakness consistent with LG myasthenia, one of the patients presented with additional distal muscle involvement in the lower extremities. By contrast, the other patient had severe bulbar and respiratory deficit requiring gastric tube feeding and mechanical ventilatory support for most parts of the day.

Discussion:
These 2 cases illustrate the lack of phenotype–genotype correlation and the absence of geographic, genetic, and ethnic association in cases of LG CMS caused by DOK7 mutations.
LIFELONG PROGRESSIVE RETINAL ATROPHIC LESIONS IN A PATIENT WITH PARTIAL ACQUIRED LIPODYSTROPHY (BARRAQUER–SIMONS SYNDROME)
Authors: Gaboriau Thibaut , Rigalleau Vincent , Rougier Marie-Bénédicte , Korobelnik Jean-François , Delyfer Marie-Noëlle 
Published: August 2019

Purpose:
To report a case of lifelong progressive retinal atrophic lesions in a patient with partial acquired lipodystrophy, that is, Barraquer–Simons syndrome.

Methods:
Case report.

Results:
A 67-year-old female patient with Barraquer–Simons syndrome was referred for progressive visual loss. Barraquer–Simons syndrome is a rare acquired partial lipodystrophy characterized by a loss of subcutaneous fat in the upper half of the body. Fundus examination disclosed posterior atrophic lesions, particularly evident on autofluorescence images, and their progression as compared to a previous examination performed nine years earlier. Multimodal imaging confirmed the posterior atrophic lesions without any associated exudative signs and highlighted the extension of atrophic areas in the periphery.

Conclusion:
We here report for the first time a documented progressive retinal atrophy associated with Barraquer–Simons syndrome. Drusen and neovascular complications have already been described in previous reports, but no long-term follow-up was available until the present case to observe such dramatic evolution of the retinal lesions.