bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiofrequency ablation of turbinates after septoplasty has no effect on allergic rhinitis symptoms other than nasal obstruction
Authors: Kang Taegu , Sung Chung Man , Yang Hyung Chae 
Published: August 2019

BackgroundIn this study we evaluated the effects of inferior turbinate radiofrequency ablation (RFA), performed after septoplasty, on patients with allergic rhinitis (AR) symptoms.MethodsThis was a prospective, randomized, controlled study involving 60 patients with both a deviated nasal septum (DNS) and AR. Those who underwent septoplasty/sham surgery constituted the Septo‐Sham group and those who underwent septoplasty/RFA formed the Septo‐RFA group. Demographic factors, pre‐ and postoperative symptom scores for allergic rhinitis (SFARs), and Nasal Obstruction and Septoplasty Effectiveness Scale (NOSE) scores were calculated. We subdivided the total SFAR (tSFAR) scores into scores for nasal obstruction (SFAR‐NO) and scores for symptoms other than nasal obstruction (SFAR‐SONO); the latter included rhinorrhea, itching, and sneezing.ResultsThe baseline characteristics were similar between the groups. The 2 types of surgery improved both the NOSE and SFAR scores. In subgroup analysis according to the type of symptoms, both types of surgery showed improvement in SFAR‐NO and SFAR‐SONO scores. However, the extent of improvement did not differ between the groups, regardless of the type of symptoms.ConclusionFor patients with both DNS and AR, both types of surgery afford postoperative symptomatic improvement. Both types of surgery yielded improvement in both nasal obstruction and symptoms other than nasal obstruction. However, performing RFA after septoplasty did not afford further short‐term symptomatic improvements. Thus, septoplasty without RFA may be optimal for patients with both DNS and AR.
Unveiling the Neutral Forms of Glutamine
Authors: León Iker , Alonso Elena R. , Mata Santiago , Cabezas Carlos , Alonso Jose Luis 
Published: August 2019

AbstractNeutral glutamine has been evaporated by laser ablation of its solid sample to seed a rare gas carrier prior to a supersonic expansion and proved by Fourier transform microwave techniques. We report on three distinct neutral conformers that show a singular non‐interacting and flexible amide sidechain in contrast with the other proteinogenic aliphatic amino acids. It could explain the essential biological role of glutamine as a nitrogen source, and its unique ability to form a variety of hydrogen bonds with peptide backbones. Common computational methods fail to predict the delicate balance of intramolecular interactions controlling the geometry of the most stable conformer. The spectroscopic data here reported can be used to benchmark novel computational methods in quantum chemistry.
“She was on my side, and grounded me when I needed it:” Research supervision in the field of therapy, based on counsellors’ and psychotherapists’ views on their engagement with research
Authors: Bager Charleson Sofie 
Published: August 2019

AbstractResearch‐supported practice is increasingly emphasised within counselling and psychotherapy at all stages of training. Guided by an interest in how to support therapists in their efforts to develop research knowledge during doctoral training, this paper focuses on research supervision. Research supervision is a surprisingly under‐researched area. Little is known to date about how supervisors “go about their supervision” (Bruce & Stoodley, 2013, p. 5), despite the fact that “high failure rates for research dissertations in the social sciences have been partly attributed to student dissatisfaction with supervision and poor student–supervisor relationships” (Armstrong, 2004, p. 134). Between 2016 and 2019, we explored accredited counsellors' and 'psychotherapists engagement with research during or after their doctoral training. This paper explores research supervision with these two previous studies serving as the backdrop (Bager‐Charleson et al., 2018; Bager‐Charleson et al., 2018b), together with a literature review into research supervision within social sciences and psychotherapy. Supervision is discussed as a crucial coping/support strategy to (a) link research with practice in therapy work, practically and epistemologically; (b) contain and make sense of the use of transformative learning; (c) balance “enculturation” with critical thinking and emancipation; and (d) support reflective and reflexive development. This paper discusses an adaptive research supervision model, akin to a “holding bond” (Stevens, 2016) which supports the student to reflexively position her/himself personally, intersubjectively, theoretically and socio‐culturally, whilst “negotiating the tension” (Lee, 2008) during a process of enculturation into the discipline, and also fostering critical thinking and emancipation to contribute to new knowledge.
Procedural and clinical performance of dual‐ versus single‐catheter strategy for transradial coronary angiography: A meta‐analysis of randomized trials
Authors: Alushi Brunilda , Lauten Alexander , Ndrepepa Gjin , Leistner David M. , Kufner Sebastian , Xhepa Erion , Landmesser Ulf , Kastrati Adnan , Cassese Salvatore 
Published: August 2019

AbstractObjectivesWe sought to compare the procedural and clinical performance of dual‐ versus single‐catheter strategy for transradial coronary angiography.BackgroundThe radial artery (RA) is recommended as the vascular access of choice in patients undergoing coronary angiography and intervention. The procedural and clinical performance of dual‐ versus single‐catheter strategy in patients undergoing transradial coronary angiography remains a matter of debate.MethodsThis is a study‐level meta‐analysis of randomized trials. The primary outcome was procedure time. The main secondary outcome was fluoroscopy time. Other outcomes of interest were contrast volume, crossover to other catheter strategy and RA spasm.ResultsA total of 2,062 patients (978 randomly assigned to dual‐catheter and 1,084 to single‐catheter strategy) included in seven trials were available for the quantitative synthesis. A dual‐catheter strategy was associated with procedure time (standardized mean difference [95% confidence intervals (CI)], 0.55 [−0.69, 1.78]; p = .32), fluoroscopy time (−0.36 [−2.39, 1.67]; p = .68) and contrast volume (−0.93 [−3.79, 1.94]; p = .44) comparable to a single‐catheter strategy. The risk for crossover was lower (risk ratio [95% CI], 0.14 [0.03, 0.70]; p = .025) while the risk for RA spasm was higher (1.81 [1.54, 2.12]; p < .001) among patients assigned to dual‐ versus single‐catheter strategy.ConclusionsThis meta‐analysis provides evidence for a comparable procedural performance of either dual‐ or single‐catheter strategy for transradial coronary angiography. The fewer crossovers with dual‐catheter strategy occur at the expense of more frequent radial artery spasm.
In Situ Local Temperature Mapping in Microscopy Nano‐Reactors with Luminescence Thermometry
Authors: van Ravenhorst Ilse K. , Geitenbeek Robin G. , van der Eerden M. J. , Tijn van Omme J. , Peréz Garza H. Hugo , Meirer Florian , Meijerink Andries , Weckhuysen Bert M. 
Published: August 2019

AbstractIn situ and operando experiments play a crucial role in understanding the mechanisms behind catalytic processes. In these experiments it is important to have precise control over pressure and temperature. In this work, we use luminescence thermometry to map the temperature distribution in a 300 μm microelectromechanical system nano‐reactor with a resolution of ca. 10 μm. These measurements showed a temperature gradient between the center and edge of the heater of ca. 200 °C (at Tset=600 °C) in vacuum and, in addition, a large offset of the local temperature of ca. 100 °C (at Tset=600 °C) in a non‐vacuum (i. e., air, He and H2) environment. The observed temperature heterogeneities can explain differences observed in the reduction behavior of Co‐based Fischer‐Tropsch synthesis catalyst particles at different locations in the nano‐reactor as determined by scanning transmission X‐ray microscopy.
Customizing the Enantioselectivity of a Cyclohexanone Monooxygenase by a Strategy Combining “Size‐Probes” with in silico Study
Authors: Hu Yujing , Xu Jian , Cen Yixin , Li Danyang , Zhang Yu , Huang Meilan , Lin Xianfu , Wu Qi 
Published: August 2019

AbstractEnzymatic Baeyer‐Villiger oxidation provides a promising green route utilizing molecular oxygen as the oxidant to produce chiral lactones. Wild‐type (WT) CHMOAcineto leads to enantioselectivity up to 99 % ee (S) in the synthesis of substituted ϵ‐caprolactones. To reverse the inherent enantiopreference of CHMOAcineto toward an array of cyclohexanones with various chain length, we herein reshaped the binding pocket with a minimal number of mutations by a rational design strategy combining “size‐probes” with in silico study, which drastically reduces the screening effort. By probing the binding pocket of variants with different‐sized 4‐substituted cyclohexanones substrates, single, double and triple mutants were identified as the best mutants providing highly reversed enantioselectivity for these probing molecules, respectively. The successful demonstration of the strategy combining “size‐probes” with in silico study in the protein engineering of CHMOAcineto may provide a valuable guidance for facile engineering other BVMOs with customized enantiopreference for the same classified substrates with their substituents on the chiral or prochiral central atom.
General and Phosphine‐Free Cobalt‐Catalyzed Hydrogenation of Esters to Alcohols
Authors: Shao Zhihui , Zhong Rui , Ferraccioli Raffaella , Li Yibiao , Liu Qiang 
Published: August 2019

Summary of main observation and conclusionCatalytic hydrogenation of esters is essential for the sustainable production of alcohols in organic synthesis and chemical industry. Herein, we describe the first non‐noble metal catalytic system that enables an efficient hydrogenation of non‐activated esters to alcohols in the absence of phosphine ligands (with a maximum turnover number of 2391). The general applicability of this protocol was demonstrated by the high‐yielding hydrogenation of 39 ester substrates including aromatic/aliphatic esters, lactones, polyesters and various pharmaceutical molecules.
Intrapatient Variability of Tacrolimus Exposure in Solid Organ Transplantation: A Novel Marker for Clinical Outcome
Authors: Kuypers Dirk R.J. 
Published: August 2019

The calcineurin‐inhibitor tacrolimus (Tac) provides an acceptable balance between prevention of allograft rejection and drug‐related adverse effects, making it the standard of care in all types of solid organ transplantation for the last 2 decades. Recent data have demonstrated that high intrapatient variability (IPV) in Tac predose trough concentrations has deleterious effects on allograft survival. The underlying mechanisms by which a high Tac IPV shortens allograft survival are acute and chronic rejection, donor‐specific anti‐HLA antibodies, and progressive fibrotic damage to the graft. Modifiable causes of high Tac IPV include medication nonadherence (MNA), drug interactions, nutritional interferences, and concurrent diseases. Recognizing high Tac IPV as an important prognostic risk factor after solid organ transplantation requires understanding of the definitions, the use of correct diagnostic metrics, and methodology. Therapeutic interventions aimed at reducing Tac IPV are targeted on improving MNA, avoiding or adjusting drug interactions, drug dosing assists, and educational support of recipients.
Individual vs household: How do different calculation patterns of catastrophic health expenditure matter? New evidence from China's critical illness insurance programme
Authors: Zhang Ying , Hu Ding , Guan Yongmei , Vanneste Jacques 
Published: August 2019

SummaryReducing the incidence and severity of catastrophic health expenditure (CHE) has been considered to be one of the most fundamental goals of the global health care financing system. China, the second largest economy and the most populous country in the world, established a critical illness insurance (CII) programme in 2012 in an effort to protect Chinese residents from CHE shocks. This paper attempts to address whether the different calculation patterns (namely, individuals vs household) of CHE matter under China's CII programme. We compare two CII models built with the World Health Organization's (WHO's) standard and the Chinese standard. Exploiting the latest China family panel studies (CFPS) dataset, we demonstrate that using household as the calculation pattern is more effective in alleviating CHE under a tight premium budget, which is consistent with the international view. This finding raises concerns about the appropriate calculation pattern of CHE in policy making.
Disclosure characteristics of firms being investigated by the SEC
Authors: Demaline Christopher J. 
Published: August 2019

AbstractThe purpose of this study is to explore the characteristics of managers' 10‐K disclosures concerning U.S. Securities and Exchange Commission (SEC) investigations. This study examined the quantitative linguistic characteristics of 171 company disclosures discussing the firms' involvement in an SEC investigation related to fraudulent financial reporting. The results suggest that these disclosures have a relatively negative sentiment and were relatively difficult to read. The results failed to provide sufficient statistical evidence to support the notion that managers systematically attempt to blame external parties for the potential wrongdoing and related investigation. The study results add to the stream of research related to impression management in corporate disclosures while also supplementing research on how companies respond to negative events such as regulatory investigations. This study may be of interest to financial regulators, investors, and accounting standards setters, all of whom are interested in maximizing the usefulness of financial information.
Mass transfer performance and correlations for CO2 absorption into aqueous blended PG/MEA in PTFE membrane contactor
Authors: Gao Ge , Gao Hongxia , Liang Zhiwu 
Published: August 2019

AbstractBACKGROUNDThe method for capturing carbon dioxide (CO2) with amine solution in a hollow fiber membrane contactor has been identified as a potential large‐scale application technology for capturing CO2 from flue gas. The mass transfer performance of CO2 relies in large extent on the operating conditions, the types of absorbents and the properties of membrane materials. Therefore selecting the appropriate absorbent and studying the effect of operating parameters on the mass transfer performance become of paramount importance.RESULTSThe experimental results showed that the blended potassium glycinate/monoethanolamine solution has better CO2 absorption performance and higher surface tension than the single monoethanolamine solution under the same conditions. Furthermore, the experimental results illustrated that the CO2 absorption flux increases as the gas velocity, CO2 partial pressure and liquid velocity increase, and decreases with the increase of CO2 loading and membrane contactor length; and the CO2 removal efficiency increases as the liquid velocity and membrane contactor length increase, and decreases with the increase of CO2 loading, gas velocity and CO2 partial pressure. Additionally, new correlations for the prediction of the CO2 absorption flux JCO2 and the CO2 removal efficiency ηCO2 are proposed in this work. The calculated data of CO2 absorption flux and CO2 removal efficiency were found to be in satisfactory agreement with experimental results, with absolute average deviation (AAD) lower than 4.42%.CONCLUSIONThe correlations for the prediction of JCO2 and ηCO2 based on the experimental results are of significance for predicting the operating parameters and design of a polytetrafluoroethylene (PTFE) hollow fiber membrane contactor. © 2019 Society of Chemical Industry
Fabry disease genotype, phenotype, and migalastat amenability: Insights from a national cohort
Authors: Nowak Albina , Huynh‐Do Uyen , Krayenbuehl Pierre‐Alexandre , Beuschlein Felix , Schiffmann Raphael , Barbey Frédéric 
Published: August 2019

AbstractFabry disease (FD) is a rare X‐linked lysosomal storage disorder caused by α‐galactosidase A (α‐Gal A) deficiency. The progressive accumulation of globotriaosylceramide results in life‐threatening complications, including renal, cardiac, and cerebrovascular diseases. The pharmacological chaperone migalastat was recently approved as an alternative to enzyme replacement therapy in patients with amenable mutations. In this article, we investigate the proportion of amenable mutations, related to phenotype, in a population of adult patients with FD in Switzerland. This study included 170 adult patients (n = 64 males) from 46 independent pedigrees with 39 different identified mutations over the last 59 years. Overall, 68% had the classic phenotype and 48% fulfilled the current amenability criteria. Migalastat was stopped in 2/11 (18%) patients: the only male classic patient, because of lack of efficacy based on lyso‐Gb3 levels, and one patient with a benign variant. In males, the achieved enzyme activities in peripheral leucocytes under migalastat treatment differed from the activities in HEK‐cells after incubation with migalastat (eg, 33% in PL vs 41% HEK‐cells for p.F113L; 43% in leucocytes vs 36% in HEK‐cells for p.N215S, 24‐30% in leucocytes vs 96% in HEK‐cells for S238N). In this national cohort, we found a relatively high proportion of patients with amenable GLA mutations, which, however, had heterogeneous extent of amenability: the higher the residual α‐Gal A activity, the higher the chaperone effect. Further studies are required to investigate the long‐term benefits of migalastat therapy depending on the achieved enzyme activities in different amenable mutations.
The mid‐summer drought over Mexico and Central America in the 21st century
Authors: Corrales‐Suastegui Arturo , Fuentes‐Franco Ramón , Pavia Edgar G. 
Published: August 2019

AbstractThe southern Mexico and Central America (SMCA) region shows a dominant well‐defined precipitation annual cycle. The rainy season usually begins in May and ends in October, with a relatively dry period in July and August known as the mid‐summer drought (MSD); notable exceptions are the Caribbean coast of Honduras and Costa Rica. This MSD phenomenon is expected to be affected as the SMCA experiences an enhanced differential warming between the Pacific and Atlantic Oceans (PO‐AO) towards the end of the 21st century. Previous studies have suggested that this differential warming will induce a strengthening of the westward Caribbean low‐level jet (CLLJ) and that this heightened CLLJ will shift precipitation westwards, falling on the PO instead that within the SMCA region causing a severe drought. In this work we examine this scenario with a new model, the Rossby Center Regional Climate Model (RCA4), for the COordinated Regional climate Downscaling EXperiment (CORDEX) Central America domain, forced with different general circulation models (GCMs) and for different representative concentration paths (RCPs). We consider 25‐year periods as “present conditions” (1981–2005) and “future scenario” (2071–2095), focusing on the “extended summer” season (May–October). Results suggest that in the future the spatial extension of the MSD will decrease and that in certain areas the MSD will be more intense but less frequent compared to present conditions. Also, the oceanic differential warming, the intensification of the CLLJ, and the reduction in regional precipitation in the future scenario, suggested by previous works, were verified in this study.
Tourism and the city: The impact on residents' quality of life
Authors: Biagi Bianca , Ladu Maria Gabriela , Meleddu Marta , Royuela Vicente 
Published: August 2019

AbstractThe present work investigates the relationship between tourism presence and perceptions of the urban quality of life (UQoL) of resident populations. This is currently a hot topic, because in many European cities, residents have started to voice concerns about mass tourism. An ad hoc questionnaire was designed and submitted to the resident populations of two Mediterranean destinations. Following an integrative approach à la Sen, UQoL is analysed using the presence of services/amenities (capabilities) as well as their accessibility (functionings). Findings indicate that both presence and—mainly—accessibility of services/amenities matter for UQoL and that a negative effect from tourism prevails.
Distribution of mercury‐cycling genes in the Arctic and equatorial Pacific Oceans and their relationship to mercury speciation
Authors: Bowman Katlin L. , Collins R. Eric , Agather Alison M. , Lamborg Carl H. , Hammerschmidt Chad R. , Kaul Drishti , Dupont Christopher L. , Christensen Geoff A. , Elias Dwayne A. 
Published: August 2019

AbstractHumans are exposed to potentially harmful amounts of the neurotoxin monomethylmercury (MMHg) through consumption of marine fish and mammals. However, the pathways of MMHg production and bioaccumulation in the ocean remain elusive. In anaerobic environments, inorganic mercury (Hg) can be methylated to MMHg through an enzymatic pathway involving the hgcAB gene cluster. Recently, hgcA‐like genes have been discovered in oxygenated marine water, suggesting the hgcAB methylation pathway, or a close analog, may also be relevant in the ocean. Using polymerase chain reaction amplification and shotgun metagenomics, we searched for but did not find the hgcAB gene cluster in Arctic Ocean seawater. However, we detected Hg‐cycling genes from the mer operon (including organomercury lyase, merB), and hgcA‐like paralogs (i.e., cdhD) in Arctic Ocean metagenomes. Our analysis of Hg biogeochemistry and marine microbial genomics suggests that various microorganisms and metabolisms, and not just the hgcAB pathway, are important for Hg methylation in the ocean.
Influence of process variables on the characteristics of friction‐stir‐welded polyamide 6,6 joints
Authors: Nandhini R. , Moorthy M. Kesava , Muthukumaran S. , Kumaran S. 
Published: August 2019

AbstractThis paper aims to study the feasibility of friction stir welding of thermoplastic material polyamide 6,6. The maximum joint strength achieved through the optimized process variables is 41 MPa. The maximum temperature rise of 126 °C is achieved and the weld nugget exhibits a hardness of 69 D on Shore hardness scale. Fractography analysis reveals that the fracture followed a continuous plastic flow comprising less prominent fibrillation and more elongated voids. An increase in glass transition temperature Tg is observed in the weld specimen. The impact of the welding process variables on the frequency and band shift of the functional groups of the polymer is also discussed.
Cutting tool holding device with controlled oscillation without external energy source and experimental analysis of its advantages when turning
Authors: Vasilko K. , Murčinková Z. 
Published: August 2019

AbstractThis paper presents the design of a cutting tool‐holding device with controlled oscillations without an external energy source based on a varying machining force, and an experimental analysis involving the influence on the chip shape, tool‐wear, chip volume coefficient, and surface roughness. The design of the cutting tool‐holding device is based on reducing the dynamic stiffness by allowing one degree of freedom of the cutting tool, either translationally or rotationally. This paper analyses the advantages of such a design, and provides experimental measurement results presenting the advantages of the concept of a partially movable tool holder without an external energy source for application in other machining operations.