bluuebunny/crossref_metadata_2025_split huggingface dataset:
An overview and critique of the Test of Visual Perception Skills – fourth edition (TVPS-4)
Authors: Brown Ted , Peres Lisa 
Published: September 2018

Introduction The Test of Visual Perception Skills – fourth edition (TVPS-4) is an updated version of the Test of Visual Perception Skills – third edition (TVPS-3). The TVPS-4 is a standardized assessment of motor-free visual perception skills for individuals aged 5–21 years. Test norms were derived from a normative sample that reflected the United States population. Method The present paper outlines and appraises the reliability and validity of the TVPS-4. Measurement properties of the TVPS-4 were critiqued using the Quality Criteria for Health Status Questionnaires (QCHSQ) and the Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) checklist with 4-point rating scale. Results The TVPS-4 manual reports details of reasonable levels and types of overall reliability and validity. The QCHSQ and COSMIN checklist reviews suggested that further research is needed in relation to the TVPS-4’s measurement error, reproducibility, internal consistency and cross-cultural validity. Conclusion The TVPS-4 is an in-depth assessment that can be used to identify areas of impairment and assist with goal setting and intervention planning. The impact of the TVPS-4 on occupational therapy practice is also considered. Future research could investigate the cross-cultural validity of the TVPS-4 so that it can be used in other countries with confidence.
Altered duodenal bile salt concentration and receptor expression in functional dyspepsia
Authors: Beeckmans Dorien , Riethorst Danny , Augustijns Patrick , Vanuytsel Tim , Farré Ricard , Tack Jan , Vanheel Hanne 
Published: September 2018

BackgroundFunctional dyspepsia is a common functional gastrointestinal disorder in which a variety of pathophysiological mechanisms such as increased intestinal permeability and low‐grade inflammation are involved. The factor causing these alterations, however, has not been identified.ObjectiveWe aimed to evaluate the luminal bile salt content and receptor expression in patients with functional dyspepsia and healthy volunteers.MethodsGastroduodenoscopy was performed to obtain duodenal biopsies from 25 healthy volunteers and 25 patients with functional dyspepsia (Rome III) to measure duodenal bile salt receptor expression with Western blot. Duodenal fluid aspirates were collected at fixed time points during fasted and fed state conditions and bile salt composition analysis was performed by liquid chromatography‐mass spectrometry/mass spectrometry.ResultsPatients (N = 17) displayed decreased fasted bile salt concentrations compared to healthy volunteers (N = 20) over time (1.8 ± 0.3 mM vs 3.6 ± 0.5 mM; p = 0.03). In addition, an increased expression of duodenal bile salt sensor vitamin D receptor was found in patients (3.7 ± 1.0‐fold; p < 0.0005; N = 24 for both groups).ConclusionPatients with functional dyspepsia are characterized by a decreased duodenal bile salt concentration in fasted state and an increased duodenal vitamin D receptor expression.
The impact of patient age on toxicity and efficacy of immunotherapy agents.
Authors: Zhang Shuai , Samani Amit , Spiers Laura , Tippu Zayd , Suwaidan Ali Abdulnabi , Merrick Sophie , Van Hemelrijck Mieke , Payne Miranda , Faust Guy , Papa Sophie , Josephs Debra Hannah 
Published: September 2018

e15116 Background: Little data exists for the use of immune checkpoint inhibitors (ICI) in patients ≥80y old. Ageing is associated with immunosenescence, which may impact the efficacy and toxicity of immune-based therapies. Here we provide efficacy and immune related adverse event (irAE) data for patients ≥80y old and younger patient cohorts treated in routine clinical practice at 3 UK Cancer Centres: Guy’s and St Thomas’ NHS Foundation Trust, Oxford University Hospitals NHS Foundation Trust and University Hospitals of Leicester NHS Trust. Methods: Melanoma, renal cell carcinoma (RCC), non-small cell lung cancer (NSCLC) and urothelial carcinoma (UC) patients treated with ICIs between March 2016 – August 2018 were identified, and divided into five age-defined cohorts: < 50y, 50-59y, 60-69y, 70-79y, ≥80y. Median progression free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method with data censored on 5th February 2018. Frequency and severity of five common irAEs were determined: hepatitis, endocrinopathies, immune-related gastrointestinal, skin and rheumatological. Results: 386 patients aged 22 – 98y (median 67y) received single-agent nivolumab (21%), pembrolizumab (62%), ipilimumab (10%) or combination ipilimumab and nivolumab (7%). 12% of patients were aged < 50y, 18% were 50-59y, 29% were 60-69y, 28% were 70-79y and 13% were ≥80y. Response rates (partial + complete response) were similar across all age groups (53% < 50y, 29% 50-59y, 48% 60-69y, 43% 70-79y and 47% ≥80y). Median PFS was 10.6, 10.3, 10.0, 5.8 and 19.7 months and OS was not reached, not reached, 29.0, 18.3, and 20.9 months for patients < 50y, 50-59y, 60-69y, 70-79y and ≥80y, respectively. The rate of any grade irAEs was lowest in patients ≥80y (59%), and highest in patients < 50y (92%). Grade 3-5 irAEs were also less frequent in patients ≥80y (10%) than those < 50y and 60-69y (both 18%). Conclusions: Of 386 patients 13% were ≥80y with response rates comparable to younger patient cohorts and rates of irAEs lower than younger patient cohorts in this retrospective analysis of a heterogenous patient population. Our data suggests that ICIs are well-tolerated and efficacious in elderly patients and that age alone should not preclude ICI use.
Effects of EPO on Blood Parameters and Running Performance in Kenyan Athletes
Authors: HAILE DIRESIBACHEW W. , DURUSSEL JÉRÔME , MEKONEN WONDYEFRAW , ONGARO NEFORD , ANJILA EDWIN , MOOSES MARTIN , DASKALAKI EVANGELIA , MOOSES KERLI , MCCLURE JOHN D. , SUTEHALL SHAUN , PITSILADIS YANNIS P. 
Published: September 2018

ABSTRACTIntroductionRecombinant human erythropoietin (rHuEpo) administration enhances oxygen carrying capacity and performance at sea level. It remains unknown whether similar effects would be observed in chronic altitude-adapted endurance runners. The aim of this study was to assess the effects of rHuEpo on hematological and performance parameters in chronic altitude-adapted endurance runners as compared to sea level athletes.MethodsTwenty well-trained Kenyan endurance runners (KEN) living and training at approximately 2150 m received rHuEpo injections of 50 IU·kg−1body mass every 2 d for 4 wk and responses compared with another cohort (SCO) that underwent an identical protocol at sea level. Blood samples were obtained at baseline, during rHuEpo administration and 4 wk after the final injection. A maximal oxygen uptake (V˙O2max) test and 3000-m time trial was performed before, immediately after and 4 wk after the final rHuEpo injection.ResultsHematocrit (HCT) and hemoglobin concentration (HGB) were higher in KEN compared to SCO before rHuEpo but similar at the end of administration. Before rHuEpo administration, KEN had higher V˙O2maxand faster time trial performance compared to SCO. After rHuEpo administration, there was a similar increase in V˙O2maxand time trial performance in both cohorts; most effects of rHuEpo were maintained 4 wk after the final rHuEpo injection in both cohorts.ConclusionsFour weeks of rHuEpo increased the HGB and HCT of Kenyan endurance runners to a lesser extent than in SCO (~17% vs ~10%, respectively) and these alterations were associated with similar improvements in running performance immediately after the rHuEpo administration (~5%) and 4 wk after rHuEpo (~3%).
A case series report of cancer patients undergoing group body psychotherapy
Authors: Grossert Astrid , Meinlschmidt Gunther , Schaefert Rainer 
Published: September 2018

Background: Disturbances in bodily wellbeing represent a key source of psychosocial suffering and impairment related to cancer. Therefore, interventions to improve bodily wellbeing in post-treatment cancer patients are of paramount importance. Notably, body psychotherapy (BPT) has been shown to improve bodily wellbeing in subjects suffering from a variety of mental disorders. However, how post-treatment cancer patients perceive and subjectively react to group BPT aiming at improving bodily disturbances has, to the best of our knowledge, not yet been described. Methods: We report on six patients undergoing outpatient group BPT that followed oncological treatment for malignant neoplasms. The BPT consisted of six sessions based on a scientific embodiment approach, integrating body-oriented techniques to improve patients’ awareness, perception, acceptance, and expression regarding their body. Results: The BPT was well accepted by all patients. Despite having undergone different types of oncological treatment for different cancer types and locations, all subjects reported having appreciated BPT and improved how they perceived their bodies. However, individual descriptions of improvements showed substantial heterogeneity across subjects. Notably, most patients indicated that sensations, perceptions, and other mental activities related to their own body intensified when proceeding through the group BPT sessions. Conclusion: The findings from this case series encourage and inform future studies examining whether group BPT is efficacious in post-treatment cancer patients and investigating the related mechanisms of action. The observed heterogeneity in individual descriptions of perceived treatment effects point to the need for selecting comprehensive indicators of changes in disturbances of bodily wellbeing as the primary patient-reported outcome in future clinical trials. While increases in mental activities related to their own body are commonly interpreted as important mechanisms of therapeutic action in BPT, follow-up assessments are needed to evaluate intended and unintended consequences of these changes in cancer patients.
MULTIMODALIDADES E LEITURAS: FUNCIONAMENTO COGNITIVO, RECURSOS SEMIÓTICOS, CONVENÇÕES VISUAIS - LIVRO DE ANGELA PAIVA DIONISIO, LEILA JANOT DE VASCONCELOS E MARIA MEDIANEIRA DE SOUZA
Authors: Da Silva Silvio Profirio , De Lucena Josete Marinho 
Published: September 2018

Resenha do livro de DIONISIO, A. P., VASCONCELOS, L. J., SOUZA,M.M. Multimodalidades e Leituras: funcionamento cognitivo, recursos semióticos, convenções visuais. Recife: Pipa Comunicação, 2014.
Stomaching the pain of spinal fusion: Gastrointestinal discomfort is as severe as back pain in 50% of adolescent idiopathic scoliosis patients following posterior spinal fusion
Authors: Villamor G. A. , Andras L. M. , Chan P. , Jalloh H. , Sanders A. E. , Yang J. , Choi P. D. , Tolo V. T. , Skaggs D. L. 
Published: September 2018

Purpose There have been no prospective studies investigating gastrointestinal (GI) symptoms of patients with adolescent idiopathic scoliosis (AIS) following posterior spinal fusion (PSF). The purpose of this study was to evaluate the incidence and severity of self-reported GI symptoms following PSF. Methods In all, 40 AIS patients undergoing PSF were prospectively enrolled between March 2015 and October 2016. Patients completed a survey on each postoperative, inpatient day regarding nausea, emesis, constipation, abdominal pain and back pain, rating their pain on a scale of 1 to 10. Results Abdominal pain (50%), emesis (63%), nausea (65%) and constipation (68%) were experienced by the majority of patients. Of those reporting back pain, the mean pain level during the postoperative period was 5.1 (0.2 to 9.6). Of those reporting abdominal pain, the mean pain level during the postoperative period was 5.5 (1.4 to 8.6), which was not different than the severity of their back-pain levels (mean = 6.0, p = 0.31). Conclusions Gastrointestinal issues in AIS patients following PSF are common. Abdominal pain was as severe as the back pain for half of the patients. Level of Evidence II
The mechanism of antibacterial activity of corylifolinin against three clinical bacteria from Psoralen corylifolia L
Authors: He Nan , Zhou Juan , Hu Miyun , Ma Changyang , Kang Wenyi 
Published: September 2018

AbstractEffective antibacterial activity against Grampositive bacteria isolated in clinical strains was exhibited when corylifolinin was tested using the Disc diffusion method (K-B method). Minimum inhibitory concentration (MIC) of corylifolinin against Staphylococcus aureus (SA), Methcillin-resistant Staphylococcus aureus (MRSA) and extended spectrum β-lactamases Staphylococcus aureus (ESBLs-SA) were 0.078, 0.156 and 0.078 mg/mL, respectively. The minimum bactericide concentrations (MBCs) were 0.156, 0.156 and 0.078 mg/mL respectively. Scanning electron microscopy (SEM), alkaline phosphatase (AKP) and bacterial extracellular protein leakage were used to investigate the antibacterial mechanism of corylifolinin. After adding corylifolinin at the MBC level, there were obvious changes to the Staphylococcus aureus of bacteria cells. Both MIC level and MBC levels of corylifolinin led to the leakage of AKP and bacterial extracellular protein.
Crystal structure of (Z)-2-bromo-3-(3,5-di-tert-butyl-4-hydroxyphenyl)-1-phenylprop-2-en-1-one, C23H27BrO2
Authors: Khalilov Ali N. , Asgarova Ayten R. , Gurbanov Atash V. , Maharramov Abel M. , Nagiyev Farid N. , Brito Iván 
Published: September 2018

Abstract
C23H27BrO2, P21/n (no. 14), a = 10.3200(18) Å, b = 15.905(3)(6) Å, c = 12.913(2) Å, β = 97.683(4), V = 2100.6(6) Å3, Z = 4, R
gt(F) = 0.0319, wR
ref(F
2) = 0.0872, T = 296(2) K.
Literature, Art and the Democracy to Come: A Legal Approach to The Danish Girl
Authors: Ribeiro Fernando Armando 
Published: September 2018

Abstract
This paper intends to be a legal-philosophical approach to the film The Danish Girl, which tells the story of the first person to undergo a sex change surgery. However, the paper does not attempt to address the preeminent question in the movie, concerning gender issues. Our proposal comes from the hypothesis of art as the best conceivable place for the invention of an “other” that comes. The reflections brought about by the film point to the very heart of the Law and Humanities movement, since it shows how otherness may precede any conceptual dimension, as well as the important question concerning the possibility (or necessity?) of transformation of Law through art. Therefore, we will try to show how the idea of literature, based on Derrida’s concept,
Jacques Derrida, Positions (Belo Horizonte: Autêntica, 2001). could indicate a possible ethical path to implement the confluence between legal and artistic narratives, presenting itself as a fertile soil for the opening to the otherness that comes, towards the transformation of the very idea of justice.
Behandlung und Prävention von Diabetes: Erfolge und Herausforderungen
Authors: Bitzer Barbara , Müller-Wieland Dirk 
Published: September 2018

ZusammenfassungDiabetes hat sich in Industrieländern zu einer der häufigsten Krankheiten entwickelt. In Deutschland ist fast jeder Zehnte betroffen. Maßgeblich dazu beigetragen hat die Zunahme von Risikofaktoren wie Adipositas. Eine verbesserte Versorgung konnte zwar für mehrere Folgeerkrankungen die Inzidenzrate senken, jedoch haben Betroffene nach wie vor eine verkürzte Lebenserwartung. Die aktuelle Herausforderung ist, die Zunahme von Diabetes zu stoppen. Notwendig ist mehr Verhältnisprävention.
Dietary aspects of the West Lithuanian people during the Late Roman and Early Migration periods with reference to household and funerary pottery
Authors: Bliujienė Audronė , Matulaitienė Ieva , Garbaras Andrius , Šapolaitė Justina , Ežerinskis Žilvinas , Ulozaitė Regina , Bračiulienė Ramunė 
Published: September 2018

Zusammenfassung
Die vorliegende Studie präsentiert die Ergebnisse einer integrierten interdisziplinären Untersuchung von Rückständen verkohlten organischen Materials bzw. Lebensmittelkrusten, die auf der inneren Keramikoberfläche haften und eine wertvolle Informationsquelle für die menschliche Ernährung darstellen. FTIR und Isotopenverhältnis-Massenspektrometrie wurden verwendet, um Haushaltsgefäßen und Miniaturtöpfen zu analysieren, die in der Zeit zwischen dem 3. und der Mitte des 5. Jahrhunderts in Westlitauen mit Toten als Beigaben in Vestattungen gelangten. Die δ13C-Isotopenanalyse zeigt einen beträchtlichen Unterschied zwischen den Rückständen von Haushalts- und Grabkeramik. Die δ13C-Isotopenverhältnisse in den Proben von Miniaturpotentiometern variieren von −28,0 ‰ bis −28,8 ‰. Isotopenwerte in einem relativ engen Bereich weisen darauf hin, dass in den Töpfen vorhandenes organisches Material ähnlichen Ursprungs war. δ13C-Isotopenverhältniswerte lassen vermuten, dass niedergelgte Miniaturtöpfe mit Bier aus Gerste und/oder Hafer gefüllt waren. Der δ15N-Isotopenwert (δ15N = 8,0 ‰) und die Carboxyl-Gruppe der C-O-Gruppe sowie die Polysaccharide zeigen das Vorhandensein von Proteinen in einigen der Miniaturtöpfen an, so dass außerdem angenommen werden kann, dass diese mit fermentiertem Milchgetränk gefüllt waren. Die Miniaturtöpfe wurden in den Bestattungen platziert und mit einer symbolischen Menge Bier oder fermentierten Getränken auf Milchbasis gefüllt (40/50 bis 100 ml). Das Kohlenstoffisotopenverhältnis der Haushaltsgefäße variierte von −23,9 ‰ bis −27,9 ‰, was auf eine auf Getreide vom Typ C3 basierende Ernährung hindeutet. Die aus organischen Rückständen gewonnenen δ15N-Werte liegen zwischen 3,1 ‰ und 9,9 ‰, was als Hinweis zu verstehen ist, dass Bestandteil der menschlichen Ernähung auch Pflanzen- und Allesfresser waren. Zusammenfassend zeigt die Analyse, dass die konsumierte Nahrung terrestrischen Ursprungs ist und aus der Landwirtschaft und der Tierzucht stammt.
A General Algorithm on the Natural Vibration Analysis of Composite Beams with Arbitrary Complex Interfaces
Authors: Li Botong , Liu Chein-Shan , Zhu Liangliang 
Published: September 2018

Abstract
In the present work, a novel mathematical scheme is developed to investigate the transverse natural vibration of composite materials with complex interfaces, which belong to the extreme mechanical category. Two kinds of interfaces, as examples, are used to demonstrate the mathematical scheme. One is the triangular wave interface that has non-differentiable points in its interface description function, and the other is the square wave interface that has discontinuity points in its interface description function. The non-differentiable points or the discontinuity points in the description interface functions can pose great challenge for traditional mathematical/mechanical treatments dealing with the vibration problem. Governing equations of the composites are derived according to the generalized Hamiltonian principle. For the piecewise interface function of the triangular/square wave interface, as it is not a continuous and derivative function, the Fourier expansion method with finite terms is adopted to approximate the piecewise function in the calculations. The proposed iterative scheme can quickly find the natural frequencies of the composites, with the help of the Rayleigh quotient and boundary functions. The obtained natural frequencies are compared with those obtained from the finite element method. The effects of interface geometrical properties (the amplitude and the number of waves of the interface) on the natural frequencies are investigated systematically, and we show a plausible way to tune the natural frequencies of the composites by changing the interface geometries.
Amplified Tunnelling from a Pair of Balanced Loss and Gain Cavities
Authors: Fang Yun-Tuan , Li Xiao-Xue 
Published: September 2018

Abstract
An exceptional point (EP) or pole is an extraordinary physical phenomenon of a parity-time (PT)-symmetric system. In this article, we design a compact pseudo-PT-symmetric system in which a gain resonator and a loss resonator are connected by a metal film. An amplified tunnelling is found with the coupling of the two resonators induced by the plasmonic resonance. Both EP and the pole effects can result in a jump in the transmittance and reflectance with nearly equal, large values. The pole effect can be achieved by adjusting either the gain coefficient or the incidence angle.
An Investigation on the Effects of Cellulose Nanofibrils on the Performance of Cement Paste and Concrete
Authors: Haddad Kolour Hosain , Ahmed Mohammed , Alyaseen Ethar , Landis Eric N. 
Published: September 2018

AbstractCellulose nanofibrils (CNFs) have the potential to enhance cement and concrete properties because of the way they change both how water is distributed during mixing and how they modify the hydration process. In this work, the effects of CNFs on certain properties of cement paste and concrete were investigated. For the cement paste, workability, shrinkage properties, and compressive strength were investigated. In the cement paste study, 32 batches with variable CNF concentrations in 4 groups with different water-to-cement (w/c) ratios (0.35, 0.40, 0.45, and 0.50) were prepared and tested. Two rheological tests were performed; one used an ammeter to measure torque versus rotational speed, and a second used a standard flow table. Both tests showed a decrease in the workability of cement pastes that was due to the increase in CNF volume for all pastes, which suggests that CNF retains mix water in the fresh state. Thus, the water held in the CNF is not available during initial mixing of the cement paste. The results of the free shrinkage tests for all 32 cement pastes were collected for up to 90 days. Additional results showed that at a low w/c ratio (0.35), adding a small quantity of CNF (0.05 %) can reduce free shrinkage by 13 %. In compressive strength tests, a small dosage of CNF (0.05 %) improved compressive strength (up to 28 %), but higher dosages reduced strength. Results suggest that CNF has a good potential to be considered as a new natural plant-based internal curing agent in cement paste and concrete. For the concrete specimens, the primary focus was on workability effects and compressive strength. In the concrete study, twelve batches with different CNF volumes were prepared, and the corresponding slump results were measured. Results showed that to preserve the slump values, extra water content of 5–8 % should be added for every 0.1 % of CNF incorporated in the concrete mixture. Based on compressive strength tests, it has been shown that CNF is the weakest link in concrete microstructures and controls the compressive strength.
Experimental Research on Explosively Driven Crack Initiation and Propagation from Flaws of Various Geometry
Authors: Yang Renshu , Zuo Jinjing 
Published: September 2018

Abstract
The aim of this study is to explore the fracture dynamic properties of defect bodies under explosion loading by using the system of digital laser dynamic caustics test. The propagation of directional cracks and the fracture process of defect bodies have been observed by high-speed camera, as well as analyzed for the changing rules of speed and stress intensity factors when the directional crack was close to defect. Experimental results found that the defect has an inhibitory effect on the spreading of cracks when the detonation crack is extended toward the defect. With the decrease of the curvature of the elliptical defect, the energy accumulation rate decreases with the decrease of the curvature in the process of the generation of the cracks at the endpoints of wings, and its fracture toughness increases with the decrease of the curvature, and when the curvature is reduced to a certain extent, the wing crack cannot crack. The dynamic stress intensity factor of the crack tip has a positive correlation with the velocity of cracking, within a certain range. The fracture toughness of the crack at the time it begins is larger than during its spreading.