bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arrhythmias in children with a single ventricle
Authors: Plotnikova I. V. , Dzhaffarova O. Yu. , Svintsova L. I. , Saushkin V. V. , Kovalev I. A. 
Published: July 2018

Aim. The paper presents prevalence and disturbances of cardiac rhythm and conduction in children with a single ventricle (SV) at different stages of hemodynamic defect correction. It also analyzes risk factors of arrhythmia.Materials and methods. A total of 70 patients with SV was performed all stages of hemodynamic correction of defect. To assess disorders of rhythm and conduction, echocardiography, pulseoxymetry, cardiac catheterization, pulmonary angiography, ECG, and Holter monitoring were performed before and after surgery on all children at every stage of hemodynamic correction.Results. Absence of heart rhythm disturbances (HRD) at 1st stage of hemodynamic correction was 98.1%, at 2nd – 80%, at 3rd – 48.6% and at 4th – 41.5%. Sinus node dysfunction is the most often HRD from the second stage of hemodynamic correction. Statistical analysis showed significant decrease of saturation ((73 ± 12) и (81 ± 4)% correspondingly, p < 0.05) and increase of average pressure in the pulmonary artery after TCPC ((9.6 ± 4.2) and (11.5 ± 5.8)% correspondingly, p < 0.05) in children with heart rhythm disturbances in comparison to children without arrhythmias. The average age of children with arrhythmias after TCPC and after fenestration closure, correspondingly, was significantly higher than in the group of children without arrhythmias ((72 ± 43) mon and (52 ± 27) mon correspondingly, p < 0.05). Studies of arrhythmias in children with SV require follow-up as they significantly influence on the disease and life quality.
Current Highlights About the Safety of Inorganic Nanomaterials in Healthcare
Authors: Perioli Luana , Pagano Cinzia , Ceccarini Maria Rachele 
Published: July 2018

:
In recent years inorganic materials are largely present in products intended for
health care. Literature gives many examples of inorganic materials used in many healthcare
products, mainly in pharmaceutical field.

:
Silver, zinc oxide, titanium oxide, iron oxide, gold, mesoporous silica, hydrotalcite-like compound
and nanoclays are the most common inorganic materials used in nanosized form for
different applications in the health field. Generally, these materials are employed to realize
formulations for systemic use, often with the aim to perform a specific targeting to the pathological
site. The nanometric dimensions are often preferred to obtain the cellular internalization
when the target is localized in the intracellular space.

:
Some materials are frequently used in topical formulations as rheological agents, adsorbents,
mattifying agents, physical sunscreen (e.g. zinc oxide, titanium dioxide), and others.

:
Recent studies highlighted that the use of nanosized inorganic materials can represent a risk
for health. The very small dimension (nanometric) until a few years ago represented a fundamental
requirement; however, it is currently held responsible for the inorganic material toxicity.
This aspect is very important to be considered as actually numerous inorganic materials
can be found in many products available in the market, often dedicated to infants and children.
These materials are used without taking into account their dimensional properties with
increased risk for the user/patient.

:
This review deals with a deep analysis of current researches documenting the toxicity of
nanometric inorganic materials especially those largely used in products available in the market.
Random Global and Local Optimal Search Algorithm Based Subset Generation for Diagnosis of Cancer
Authors: Meenachi Loganathan , Ramakrishnan Srinivasan 
Published: July 2018

Background:
Data mining algorithms are extensively used to classify the data, in which
prediction of disease using minimal computation time plays a vital role.

Objective:
The aim of this paper is to develop the classification model from reduced features and
instances.

Methods:
In this paper we proposed four search algorithms for feature selection the first algorithm
is Random Global Optimal (RGO) search algorithm for searching the continuous, global optimal
subset of features from the random population. The second is Global and Local Optimal (GLO)
search algorithm for searching the global and local optimal subset of features from population. The
third one is Random Local Optimal (RLO) search algorithm for generating random, local optimal
subset of features from the random population. Finally the Random Global and Optimal (RGLO)
search algorithm for searching the continuous, global and local optimal subset of features from the
random population. RGLO search algorithm combines the properties of first three stated algorithm.
The subsets of features generated from the proposed four search algorithms are evaluated using the
consistency based subset evaluation measure. Instance based learning algorithm is applied to the
resulting feature dataset to reduce the instances that are redundant or irrelevant for classification.
The model developed using naïve Bayesian classifier from the reduced features and instances is
validated with the tenfold cross validation.

Results:
Classification accuracy based on RGLO search algorithm using naïve Bayesian classifier
is 94.82% for Breast, 97.4% for DLBCL, 98.83% for SRBCT and 98.89% for Leukemia datasets.

Conclusion:
The RGLO search based reduced features results in the high prediction rate with less
computational time when compared with the complete dataset and other proposed subset generation
algorithm.
Understanding Process Variables and their Interactions for Maximizing Production of Artemisinin Derivative Artemether (Anti-Malarial Drug) Through Cunninghamella echinulata var elegans at 5 L Bioreactor Level
Authors: Dubey Kashyap Kumar , Kumar Punit 
Published: July 2018

Background:
Malaria is one of the life threatening diseases which is caused by Plasmodium
sp. of protozoa and uses Anopheles mosquitos as vector. Plasmodium vivax and Plasmodium falciparum
are common form of malaria parasite. Artemisinin is reported for its antimalarial activities and Artemether
which is a methyl ether derivative of Artemisinin, has been found effective against P. falciparum.

Methods:
In the present study, bioconversion of Artemisinin into Artemether was carried out experimentally
and the statistical tools like experimental factorial design and Response Surface Methodology
were used to find optimal conditions (concentration of Artemisinin, age of inoculum, temperature & pH)
using Cunninghamella echinulata var. elegans. Experimental conditions for maximum product recovery
from culture broth were also optimized using various polar and non-polar solvents for extraction. Artemether
purity was analyzed by reverse-phase HPLC. Experimental data was fitted in a quadratic model
and effect of various parameters was analyzed.

Results:
It was found that bioconversion of Artemisinin into Artemether is growth associated process. It
was observed that molasses used as carbon source supported production of Artemether to 3.4g/L. The
biomass and oxygen are key element affecting of bioconversion of Artemisinin into Artemether such as
higher dissolved oxygen reduced the Artemether bioconversion. The highest bioconversion of Artemisinin
into Artemether was obtained at temperature 25.5oC, 5g/L concentration of Artemisinin, at age of
inoculum of 44.5 h and at pH 6.0. Model suggested the highest bioconversion of Artemisinin into Artemether
was 54% at shake flask level which was near about experimental finding. An optimal condition
for bioconversion was also analyzed and 64% bioconversion was obtained in 5L bioreactor.

Conclusion:
The outcomes of the study provided optimum conditions for bioconversion of Artemisinin
into Artemether.
Amyotrophic Lateral Sclerosis and Oxidative Stress: A Double-Blind Therapeutic Trial After Curcumin Supplementation
Authors: Chico Lucia , Ienco Elena Caldarazzo , Bisordi Costanza , Lo Gerfo Annalisa , Petrozzi Lucia , Petrucci Antonio , Mancuso Michelangelo , Siciliano Gabriele 
Published: July 2018

Objective: To investigate the efficacy of curcumin oral supplementation (600 mg/day, Brainoil),
a natural antioxidant compound, in Amyotrophic Lateral Sclerosis (ALS).

Methods:
Patients were randomized into two groups: Group A received placebo for 3 months, then
Brainoil for the following 3 months, Group B took Brainoil for 6 months. The evaluations were conducted
at basal (T0), after 3 months of double blinded Brainoil or placebo treatment (T1), and after the
3 month open-label phase (T2). Clinical evaluations and oxidative stress biomarkers, including oxidative
protein products (AOPPs), ferric reducing ability (FRAP), total thiols (T-SH) and lactate, were
evaluated, compared to a control group, during an incremental forearm exercise test.

Results:
Over the entire study Group B showed a stable score of the ALS-FRS-r which decreased in
Group A (p<0.01), in parallel with a reduction of AOPPs (p<0.01) which was not detected into Group
A. Also FRAP exercise values remained stable in Group B, while in Group A they were reduced without
treatment at T1 (0.05<p<0.01), for then increase at T2 with introduction of therapy (p<0.05). In
Group B T1>T0 exercise lactate was lower compared to Group A (p<0.01). Compared to controls, the
whole ALS population showed a greater oxidative stress (p<0.001), those treated with curcumin
(Group B) exhibiting decreased exercise AOPPs at T2 with values approaching those of controls.

Conclusion:
Although further studies are needed to confirm these data, treatment with curcumin
shows encouraging results indicating a slight slowdown in disease progression, improving aerobic metabolism
and oxidative damage, this also contributing to deepen knowledge into the pathogenic
mechanisms of ALS.
Serum Tryptophan, Tryptophan Catabolites and Brain-derived Neurotrophic Factor in Subgroups of Youngsters with Autism Spectrum Disorders
Authors: Ormstad Heidi , Bryn Vesna , Verkerk Robert , Skjeldal Ola H. , Halvorsen Bente , Saugstad Ola Didrik , Isaksen Jorn , Maes Michael 
Published: July 2018

Background:
There is evidence that changes in neuro-immune responses coupled with dysfunctions
in serotonin metabolism underpin the pathophysiology of autism spectrum disorders (ASD).

Objective:
This study aimed to delineate whether ASD subgroups or characteristics show aberrations
in tryptophan and brain-derived neurotrophic factor (BDNF) metabolism.

Methods:
65 individuals with ASD (diagnosed according to ICD criteria) and 30 healthy control patients
were included. Measured were serum levels of tryptophan, kynurenine (KYN), kynurenic acid (KA), quinolinic
acid (QA), BDNF and PRO-BDNF and total blood 5-HT and 5-OH-tryptophan (5-HTP).

Results:
Elevated BDNF levels and lower tryptophan and KA levels were characteristics of both
childhood autism and intellectual disability disorder, whilst elevated tryptophan and lower 5-HT synthesis
were hallmarks of Asperger syndrome. A pathological MRI was associated with elevated tryptophan
and lowered KA. Abnormal EEG results and dysmorphology were both associated with an elevated
BDNF/ PRO-BDNF ratio. Any brain pathology and gastro-intestinal symptoms were accompanied
by lowered KA.

Conclusions:
Increased BDNF production and changes in the metabolism of tryptophan are associated
with many ASD characteristics, showing particularly strong associations with childhood autism and
Intellectual and Developmental Disabilities. Peripheral BDNF and tryptophan metabolism appear to
take part in the pathophysiology of autism spectrum disorders and their phenotypes.
A Tailored Web-based Advice Tool for Skiers and Snowboarders: Protocol for a Randomized Controlled Trial (Preprint)
Authors: Kemler Ellen , Gouttebarge Vincent 
Published: July 2018

BACKGROUND

Being active in sports has many positive health effects. The direct effects of engaging in regular physical activity are particularly apparent in the prevention of several chronic diseases, including cardiovascular disease, diabetes, cancer, hypertension, obesity, depression, and osteoporosis. Besides the beneficial health effects of being active, sports participation is unfortunately also associated with a risk of injuries. In the case of many sports injuries (eg, winter sports) preventive measures are not compulsory, which means that a behavioral change in sports participants is necessary to increase the use of effective measures, and subsequently prevent or reduce injuries in sports.

OBJECTIVE

The evidence-based Wintersportklaar online intervention has been developed to stimulate injury preventive behavior among skiers and snowboarders. In this article, the design of the effectiveness study will be described.

METHODS

A randomized controlled trial with a follow-up period of four months during the winter sport season will be conducted. The participants consist of inexperienced skiers and snowboarders. At baseline, skiers and snowboarders in the intervention and control groups are asked to report the injury preventive measures they usually take during their preparation for their winter sport holiday. One and three months after baseline, skiers and snowboarders are asked to report retrospectively in detail what measures they took regarding injury prevention during their current winter sport preparation and winter sport holiday. Descriptive analyses (mean, standard deviation, frequency, range) are conducted for the different baseline variables in both study groups. To evaluate the success of the randomization, baseline values are analyzed for differences between the intervention and control groups (chi square, independent T tests and/or Mann-Whitney test). Chi square tests and/or logistic regression analyses are used to analyze behavioral change according to the intention to treat principle (as initially assigned).

RESULTS

The project was funded in 2016 and enrolment was completed in 2017. Data analysis is currently under way and the first results are expected to be submitted for publication in 2018.

CONCLUSIONS

To combat the negative side effects of sports participation, the use of injury preventive measures is desirable. As the use of injury prevention is usually not compulsory in skiing and snowboarding, a behavioral change is necessary to increase the use of effective injury preventive measures in winter sports.

CLINICALTRIAL

Dutch Trial Registry NTR6233; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=6233 (Archived by WebCite at http://www.webcitation.org/6wXZPzjUi)
Mujeres y cooperativismo en Cuba hoy. Un estudio de redes sociales
Authors: Caballero Reyes Claudia María 
Published: July 2018

La creación de las Cooperativas No Agropecuarias (CNA) en Cuba está promoviendo cambios en su estructura social. Tanto mujeres como hombres se han incorporado a este nuevo espacio de oportunidades laborales, de manera que resulta pertinente analizar las ventajas y los retos que esto plantea para los cooperativistas, en especial para las mujeres, respecto a su inserción laboral y social. Para la presente investigación se utilizó un diseño mixto que incluyó la aplicación de un cuestionario sobre redes sociales y entrevistas individuales en profundidad. La muestra quedó compuesta por 76 cooperativistas no agropecuarios/as pertenecientes a cinco CNA del occidente del país. Las conclusiones muestran que se refuerzan las distancias sociales al coincidir posiciones menos favorables para las mujeres en las CNA y en otros espacios de la vida cotidiana
“From Soldiers to Generals”: Exhibition Devoted to the 70th Anniversary of Victory in the Great Patriotic War
Authors: Tatarinova Evgenia A. 
Published: July 2018

“Rumyantsev Readings”, held at the Russian State Library (RSL) on 14—15 April, were devoted this year to the 70th anniversary of Victory in the Great Patriotic War. Along with the Conference, in the RSL halls there was opened the book-illustrative exhibition “From Soldiers to Generals”, representing materials from the RSL collections, containing invaluable evidence of life during the war time: the memoirs of participants of the events, documents, monographs, published from 1941 through the present time.
Использование мультимедийных технологий в преподавании предметов, связанных с медицинской визуализацией
Authors: Гребельная Наталья Владимировна , Черняева Юлия Викторовна 
Published: July 2018

Цель работы – выявление наиболее эффективных форм представления мультимедийных презентаций в высшем и последипломном медицинском образовании.
Материал и методы. Изучена эффективность усвоения материала курса гинекологии (студенты) и ультразвуковой диагностики (врачи-курсанты), связанного с медицинской визуализацией. Часть обучаемых прослушала лекцию преподавателя, сопровождаемую мультимедийной презентацией, часть – изучала ту же презентацию и текст лекции самостоятельно. Эффективность обучения оценивали посредством тестовых заданий и субъективно обучаемым. Результаты обработаны методами непараметрической статистики.
Результаты. Преимуществами лекции преподавателя в сопровождении презентации является мультимодальность восприятия, возможность комментариев и уточнений со стороны лектора, обязательность посещения как мотивационный фактор. Основным достоинством самостоятельного изучения с использованием мультимедийных презентаций является возможность регулирования обучаемым времени и скорости изучения темы, обращения повторно к пройденной информации и к внешним источникам, а также использования презентации или отдельных изображений в последующем в процессе обучения и профессиональной деятельности.
Среди студентов результаты тестового контроля были достоверно (p<0,05) выше в группе, слушавшей лекцию преподавателя в сопровождении презентации, среди курсантов – у изучавших тот же материал самостоятельно. У студентов отмечена низкая мотивация к самостоятельному изучению материала, что влияло на качество его усвоения. Отмечено, что субъективная оценка не отображает реального уровня усвоения информации и не коррелирует с результатами тестовых заданий.
Заключение. Установлено, что мультимедийные презентации являются более эффективными, чем изображения на бумажных носителях, в обучении студентов и курсантов предметам, связанным с медицинской визуализацией. Для студентов наиболее результативным является подача визуального материала в ходе лекции, читаемой преподавателем, для врачей-курсантов – самостоятельное изучение с возможностью обращения к иным информационным ресурсам. Субъективная оценка не является достоверным критерием усвоения информации.
Ключевые слова: мультимедийная презентация, высшее образование, последипломное образование, медицинское изображение
PENGEMBANGAN PERANGKAT PEMBELAJARAN LEMBAR KERJA SISWA BERBASIS KARAKTER PADA PEMBELAJARAN ILMU PENGETAHUAN ALAM SMP
Authors: Setyawan Aji , Khoiri Nur , Patonah Siti 
Published: July 2018

Penelitian ini bertujuan untuk menghasilkan lembar kerja siswa yang lebih efektif, yaitu lembar kerja siswa berbasis karakter pada pembelajaran IPA SMP. Dimana lembar kerja siswa ini membantu siswa untuk dapat membangun pengetahuan mereka sendiri serta membantu membentuk karakter yang diharapkan. Metode yang digunakan dalam penelitian ini adalah penelitian dan pengembangan. Adapun tahap-tahap yang dilalui meliputi: penelitian dan pengumpulan informasi awal, perencanaan, pengembangan format produk awal, validasi ahli, dan uji coba pemakaian produk. Penelitian ini dilaksanakan di SMP N 1 Somagede. Subjek dalam penelitian ini adalah satu orang ahli perangkat pembelajaran (LKS), satu orang ahli materi pembelajaran (IPA SMP), dan siswa kelas VII E SMP N 1 Somagede yang berjumlah 32 orang. Teknik pengumpulan data dengan penyebaran angket tertutup. Angket ini berbentuk checklist dengan beberapa aspek penilaian dan kuosioner. Pada tahap validasi ahli, hasil penelitian menunjukkan bahwa lembar kerja siswa berbasis konstruktivisme yang dikembangkan dalam kategori baik untuk penilaian ahli perangkat pembelajaran dan dalam kategori sangat baik untuk penilaian ahli materi pembelajaran. Sedangkan pada tahap uji coba pemakaian produk, penilaian siswa dalam kategori sangat baik. Dengan demikian, dapat disimpulkan bahwa perangkat pembelajaran lembar kerja siswa berbasis karakter layak digunakan pada pembelajaran IPA SMP.
PENGARUH TEKNIK PROBING-PROMPTING TERHADAP KEMAMPUAN MEMECAHKAN MASALAH PADA PEMBELAJARAN FISIKA SISWA KELAS X SMA
Authors: Nova Anggita , Saptaningrum Ernawati , Siswanto Joko 
Published: July 2018

This research is motivated student of low ability in problem solving because students simply fixated on theory so difficult applied to real life. In learning physics concerning materials that occur naturally in the environment is not just a theory but delivered only link between the material being taught and the students in real-world situations. Therefore need a solution in the form of innovation to improve students problem-solving skills. This study aims to determine the effect of techniques probing-prompting for problem-solving skills in learning physics class X SMA N 1 Juwana academic year 2014/2015 on the subject the Law of Archimedes. This study uses a pre-experimental research design with pretest-posttest form only control group design. Samples were taken by purposive sampling that is in class X Mia 2 as a single experimental class. Analysis of the initial data including normality test, while the final data analysis including normality test, hypothesis testing, gain test, and test indicators of problem-solving skills. After analysis it was found that the experimental class are normally distributed. The results of calculations based on the t test analysis obtained by value tcount > t table that is 15.722 > 2.68 with a significance level of 5% with db = 36. Because tcount > t table then H0 is rejected and Ha is accept. From the results of t test analysis can be concluded that there are significant administration-prompting probing techniques for problem-solving skills in learning physics class X Semester 2 SMA N 1 Juwana on the subject of the law of Archimedes.
Morfologi Cerita Rakyat Sobey Kororsri (Penerapan Teori Naratologi Vladimir Propp)
Authors: Ria Lestari Ummu Fatimah 
Published: July 2018

Penelitian ini mengkaji morfologi cerita rakyat Sobey Kororsri berdasarkan teori Struktur Propp. Masalah yang akan dibahas dalam penelitian ini adalah bagaimana morfologi cerita rakyat Sobey Kororsri dalam teori Struktur Propp. Penelitian ini menggunakan metode kualitatif. Teknik pengumpulan datanya melalui studi pustaka (dokumentasi). dalam pelaksanaannya, penelitian ini menganalisis morfologi cerita rakyat Sobey Kororsri berdasarkan teori dan metode penelitian Struktur Fungsi Propp. Hasil analisis penelitian ini adalah ditemukan 21 (dua puluh satu) fungsi naratif, 3 (tiga) pola cerita, dan 6 (enam) lingkaran tindakan dalam cerita rakyat.
On an estimate of turbulent transport in a magnetized plasma (on the 90th anniversary of the birth of B B Kadomtsev)
Authors: Nedospasov A V 
Published: July 2018

Abstract
In 1964, B B Kadomtsev proposed that the results of a linear plasma instability analysis alone can be used to estimate the coefficients of turbulent transport across the magnetic field in a plasma. In this paper, we discuss examples of experimental support for this proposal that concern, specifically, the properties of a turbulent positive discharge column in a strong magnetic field, the ionization turbulence of a weakly ionized plasma in crossed electric and magnetic fields, and turbulence in a tokamak wall plasma.