bluuebunny/crossref_metadata_2025_split huggingface dataset:
MORPHOLOGICAL SUBSTANTIATION OF APPLICATION OF THE DEVELOPED STOMATOLOGIC MEDICAL PREPARATION BY THE BIOLOGICAL METHOD OF TREATINMENT OF THE PULPITIS
Authors: Ivashchenko V. A. , Adamchik A. A. , Tairov V. V. 
Published: October 2018

Aim. This study was designed for the morphological assessment of the state of tooth pulp tissues after simulated acute 29 Kubanskij nauchnyj medicinskij vestnik 2018; 25 (5) trauma under the influence of the developed dental treatment pad and three analogues in the treatment of deep caries and acute focal pulpitis.Materials and methods.In the course of the experiment the study was conducted on white laboratory rats. The cavities on the molar chewing surface of the upper jaw were formed by spherical burs. The experimentally formed lesions of the surface layer of the pulp were treated using the developed dental preparation and three analogues. Laboratory animals were withdrawn from the experiment on days 3, 7 and 30. Animal teeth were put in a 10% neutral formalin solution, decalcified for 3 days and then put into a mounting medium. The slices obtained had a thickness of 5-15 μm.Results. In the course of the experimental study we detected the activation of reactive and compensatory processes in the tooth pulp tissue with the preservation of its viability by using the developed dental therapeutic preparation and the Biodentin as a comparison preparation on the 30th day of the experiment. Histologically, these changes were expressed in an increase in the level of metabolic processes and in the activation of cellular elements of the tooth pulp tissue on the 30th day of the experiment.Conclusion. As a result of an experimental study of the developed dental therapeutic preparation for the treatment of deep caries and acute focal pulpitis, there was established a specific and multifunctional property in preventing and prophylaxis of the inflammation development and enhancing the protective properties of the pulp tissue under the influence of this preparation.Morphological evaluation of the application of the developed dental treatment pad showed a rapid arrest of the inflammatory response of the pulp tissue within 30 days and the normalization of the main components of the tooth pulp.Developed during the conducted experimental research dental therapeutic preparation confirmed its stated properties, in particular, anti-inflammatory, antiseptic, analgesic, moreover, it is not inferior in its properties to the drugs presented in the course of the experimental study.
MODERN TECHNIQUES FOR FACE AND NECK PHLEGMONS TREATMENT
Authors: Paramonova O. A. , Savchenko Ju. P. , Gerbova T. V. , Uvarova A. G. 
Published: October 2018

Aim. In the course of this study we carried out the analysis of clinical course features and assessment of microbiological structure of the wound surface in patients with face and neck phlegmons. The etiologic cause of the disease may be hemolytic streptococcus, different types of staphylococcus, mixed flora and anaerobic bacteria.Materials and methods. All patients required urgent surgical intervention: wide opening, drainage of cellular spaces with the subsequent irrigation with antiseptic solutions with the application of a combination of wound coverings "Aquacel Ag + Hydrofiber dressing", "Aquacel Ag Foam Hydrofiber dressing" and "Granuflex" (ConvaTec, the USA) with proper antibacterial therapy.Results. Comparison of clinical observations (favorable course of inflammatory process) and obtained microbiological assessment (quicker decrease of microbial content in the wound) confirms validity, high efficiency of wound covering application and clear advantage in comparison with traditional gauze bandages.Conclusion. The analysis of the causes of phlegmon on the face and neck over the past 5 years has shown a significant increase in the number of patients with traumatic, tonsilogenous and odontogenic phlegmons of the face and neck. The modern high-efficient method of local treatment with the use of wound coverings combinations makes it possible to suppress the purulent-inflammatory process at the early stage, to put the secondary stitches and shorten the period of treatment of patients.
التعزير بالسجن
Authors: AL ALI Omar 
Published: October 2018

شرع الله – تعالى- التعزير عقوبة للمجرم في الذنب الذي لا حدَّ له ولا
كفارة، وجعل التعزير علاجًا لكثير من قضايا المجتمع ومشكلاته.ومقصد الشريعة من التعزير: الردع والإصلاح، والتأهيل والتقويم؛ لذلك
ينبغي أن تكون نية المُعزر بريئة من الانتقام والتشفي ومن أشهر العقوبات التعزيرية
وأنجعها السجن، إذ فيه حبس الحرية وتقييدها.
وفي ذلك عذاب أليم للمجرم، وردع له عن الذنب، مع حفظ الكرامة الإنسانية.

والسجن
معروف لدى الأمم السابقة من عرب وترك وفرس ورومان وغيرهم، ولا يعرف تاريخ دقيق
لأول سجن في العالم. وقد أقرَّ الإسلام
التعزير بالسجن لقضايا كثيرة منها: عدم سداد الدين، ووجود التهمة، وتأديب العاصي
حتى يرجع عن معصيته ولا حدَّ لأقل مدة السجن أو لأكثرها. فلربما
لا تزيد مدته عن ساعة، وقد تستمر مدى الحياة، لذلك فصَّل الفقهاء في مدد السجن،
بما يتناسب مع كل حالة يقضيها
Preterm Labor and the Associated Factors
Authors: Adjie Seno , Meily Meily , Permatasari Ranti P 
Published: October 2018

Objective: To determine the risk factors that affect preterm labor in
Dr. Cipto Mangunkusumo Hospital.

Methods: This was an analytic descriptive study done in Emergency
Unit of Dr. Cipto Mangunkusumo Hospital from July to December
2014. We recruited all women who gave birth in Emergency Unit of
Dr. Cipto Mangunkusumo Hospital from July to December 2014 with
gestational age less than 37 weeks. Of the total sampling method, we
got 365 patients. We analyzed the data using chi square.

Results: The characteristic age of subjects were 14.0% of less than
20 years old, 69.0% of 21-35 years old, and the rest were more than
35 years old. Most subjects (93.1%) were employed, 94.5% were
married once, 62.3% of subjects had cesarean section history, 73.7%
were primiparous, only 4.4% had history more than 1 abortion, and
most of them were at 33-36 weeks of gestation. Socio-demographic
factor associated with preterm labor and Preterm Premature
Rupture of Membrane (PPROM) was age (p=0.011; OR 1.74; 95% CI
1.136-2.679). Obstetric history associated with preterm labor and
PPROM was parity (p=0.017; OR 1.78; 95% CI 1.132-2.878).

Conclusion: In this study, age and parity are associated with
preterm labor and PPROM.

[Indones J Obstet Gynecol 2017; 5-1: 3-7]

Keywords: obstetric history, parity, PPROM, preterm labor,
socio-demographic factors
Hypoglycemic potential of Elaeagnus angustifolia fruit polysaccharide on streptozotocin-induced type 2 diabetic mice
Authors: Wang Ya , Zou Hongmei , Sun Cui , Guo Tao , Feng Zaiping 
Published: October 2018

<p class="Abstract">In this study, the hyperglycemic potential of Elaeagnus angustifolia fruit polysaccharide in both normal healthy and streptozotocin-induced diabetic mice was investigated. Results showed no significant effect of E. angustifolia fruit polysaccharide on blood glucose level in normal control group, while E. angustifolia significantly suppressed the rise in blood glucose of diabetic mice. In addition, in the first two weeks of administration, the body weight was decreased both in negative control group and E. angustifolia groups, however, E. angustifolia (800 mg/kg) was recovered to the began weight in the fourth week. E. angustifolia (800 mg/kg) could markedly reduce the levels of total cholesterol, triglyceride and improve the level of high density lipoprotein-cholesterol. The results suggest that E. angustifolia could be considered as an ingredient of functional foods for diabetes.</p><p><strong>Video Clip of Methodology:</strong></p><p>10 min 19 sec <a href="https://www.youtube.com/v/a3ikXeeByP8">Full Screen</a> <a href="https://www.youtube.com/watch?v=a3ikXeeByP8">Alternate</a> </p>
New bioactive triaryl triglyceride esters: Synthesis, characterization and biological activities
Authors: Arshad Tanzila , Sheikh Hamdullah Khadim , Kazmi Mehdi Hassan , Farheen Sadia , Sohail Tehmina , Lateef Mehreen 
Published: October 2018

<p class="Abstract">Four new bioactive aryl triester derivatives of glycerol and benzoic acids were synthesized. The synthetic compounds were studied for their antimicrobial and urease inhibition activities. Esterification was carried out by using carbonyldiimidazole to enhance the acyl elimination addition reaction with benzoic acid derivatives. The structure of triglycerides were studied by EI-MS, <sup>1</sup>H, <sup>13</sup>C-NMR, FT-IR and elemental analysis. All synthetic compounds showed urease inhibition activity with highest value of IC<sub>50 </sub>value 22.4 ± 0.45 μM which is nearest to standard thiourea IC<sub>50 </sub>value (21.6 ± 0.12 μM). Except compound (3d), all other compounds exhibited antimicrobial activity against <em>Streptococcus pneumoniae, Staphylococcus epidermidis, Bacillus pumilus, Escherichia coli, Pseudomonas aeruginosa</em> and <em>Candida albican</em>.</p><p><strong>Video Clip of Methodology:</strong></p><p>7 min 59 sec <a href="https://youtube.com/v/PvGTYUxO7-4">Full Screen</a> <a href="https://youtube.com/watch?v=PvGTYUxO7-4">Alternate</a> </p>
The Management of Patients with Heart Failure and Depression: a Systematic Review
Authors: Ribeiro Débora Laésia Saraiva , Lima Sylvia Rannyelle Teixeira , Feitosa Geniefesson Leandro da Silva , Pimentel João Vitor Cândido , Mendes Herbert Lima , Rolim Neto Modesto Leite 
Published: October 2018

Background: Heart failure (HF) is a chronic and incapacitant disease with bad prognosis, and it is commonly related to psychosocial comorbidities that difficult treatment adhesion. The prevalence of depression in HF varies from 20 to 40%, occurring 3 to 5 times more frequently in patients with HF than general population. The coexistence of depressive symptoms depreciates heart condition in patients with HF: depressive symptoms predict mortality, re-hospitalization, and an augment of symptoms in those patients. Aiming to clarify certain aspects of this comorbidity, it was performed a systematic review using Scopus and MEDLINE/PubMed databases, correlating HF and depression, from January 1, 2013, to August 20, 2017, by means of the descriptors found in MeSH: “heart failure” and "depression".
Methods:Data screening applied combinations, as follows: #1. “Heart Failure” [MeSH Terms]; #2. “Depression” [MeSH Terms]; #3. “Management” [Keyword], using the following research strategy: (#1 AND #2) AND #3.
Results:Improvement in depression levels through interventions using telephone is extensively reported in literature, based on providing information about the disease, self-care accompaniment, or cognitive behavioral therapy (CBT). Because of this, it is shown as an effective alternative in depression, improving surviving rates. Equally effective interventions were the empowering of the patient and the familial engagement in caring, palliative care and multidisciplinary participation in construction of caring program.
Conclusions: Curiously, physical exercises did not show, statistically, efficiency in depression improvement, and few were the articles approaching antidepressant medications use in this class of patient.
Epidemiology and Antibiotic Susceptibility Patterns of Carbapenem Resistant Gram Negative Bacteria Isolated from Two Tertiary Care Hospitals in North Lebanon
Authors: Hamze Monzer 
Published: October 2018

Background. Antimicrobial resistance is a major public health problem worldwide. Numerous epidemiological studies reported that Lebanon is affected with high levels of antibiotic resistance. The aim of this study is to determine the prevalence and antibiotic susceptibility patterns of carbapenem resistant Gram negative bacteria in North Lebanon during the period 2015-2017.
Methods. Carbapenem resistant Gram negative bacteria were isolated from patients referring to Nini hospital and Youssef hospital center. Identification and antibiotic susceptibility testing were performed through conventional tools according to the manufacturer’s recommended procedures and the recommendations of the European Committee on Antimicrobial Susceptibility Testing, respectively.
Results. Overall, a total of 290 carbapenem resistant Gram negative bacteria were isolated. Escherichia coli was predominant and represented 39.3% of all isolates, followed by Pseudomonas aeruginosa (24.8%), Acinetobacter baumannii (22.8%), Klebsiella spp. (8.6%), Enterobacter spp. (6.6%), Pantoea spp. (1%), and Proteus vulgaris (0.3%). Our findings showed an alarming increase in the prevalence of carbapenem resistant bacteria every year. On the other hand, colistin, tigecycline, amikacin and fosfomycin remain the most effective agents against carbapenem resistant Gram negative bacteria.
Conclusion. This study provided important new laboratory data that could support specialists in infectious diseases in North Lebanon to take the appropriate decision in the treatment of patients at risk for infections with carbapenem resistant Gram negative germs.
Inhibitors of BMP‐1/tolloid‐like proteinases: efficacy, selectivity and cellular toxicity
Authors: Talantikite Maya , Lécorché Pascaline , Beau Fabrice , Damour Odile , Becker‐Pauly Christoph , Ho Wen‐Bin , Dive Vincent , Vadon‐Le Goff Sandrine , Moali Catherine 
Published: October 2018

BMP‐1/tolloid‐like proteinases belong to the astacin family of human metalloproteinases, together with meprins and ovastacin. They represent promising targets to treat or prevent a wide range of diseases such as fibrotic disorders or cancer. However, the study of their pathophysiological roles is still impaired by the lack of well‐characterized inhibitors and the questions that remain regarding their selectivity and in vivo efficiency. As a first step towards the identification of suitable tools to be used in functional studies, we have undertaken a systematic comparison of seven molecules known to affect the proteolytic activity of human astacins including three hydroxamates (FG‐2575, UK383,367, S33A), the protein sizzled, a new phosphinic inhibitor (RXP‐1001) and broad‐spectrum protease inhibitors (GM6001, actinonin). Their efficacy in vitro, their cellular toxicity and efficacy in cell cultures were thoroughly characterized. We found that these molecules display very different potency and selectivity profiles, with hydroxamate FG‐2575 and the protein sizzled being very powerful and selective inhibitors of BMP‐1, whereas phosphinic peptide RXP‐1001 behaves as a broad‐spectrum inhibitor of astacins. Their use should therefore be carefully considered in agreement with the aim of the study to avoid result misinterpretation.
Estimation of plastic deformation capacity for I‐shaped beams with local buckling under compressive and tensile forces
Authors: Kimura Yoshihiro , Suzuki Atsushi , Kasai Kazuhiko 
Published: October 2018

AbstractDuring earthquakes, I‐shaped beams installed in a braced structure are subjected to a bending moment and compressive and tensile axial forces transmitted from the braces. The buckling behavior of a beam under the impact of an earthquake is thereby more complex than that under no axial force or constant compressive axial forces considered in previous studies. In this paper, cyclic loading tests and numerical analyses are presented with emphasis on cyclic buckling behavior and moment and deformation capacity of the beams subjected to synchronized flexural and axial loading. As a result, it is confirmed that the I‐shaped beams originate local buckling under compressive axial force, whereas the strength is regained up to the full plastic bending moment under tensile force. Based on the results obtained, this paper presents evaluation formulae for estimating the ultimate strength, plastic deformation capacity, and cumulative plastic deformation capacity. Finally, an empirical formula to convert cumulative plastic deformation capacity into hysteretic energy dissipation is proposed.
Forensic voice discrimination by lay listeners: The effect of speech type and background noise on performance
Authors: Smith Harriet M.J. , Baguley Thom S. , Robson Jeremy , Dunn Andrew K. , Stacey Paula C. 
Published: October 2018

SummaryIn forensic settings, lay (nonexpert) listeners may be required to compare voice samples for identity. In two experiments we investigated the effect of background noise and variations in speaking style on performance. In each trial, participants heard two recordings, responded whether the voices belonged to the same person, and provided a confidence rating. In Experiment 1, the first recording featured read speech and the second featured read or spontaneous speech. Both recordings were presented in quiet, or with background noise. Accuracy was highest when recordings featured the same speaking style. In Experiment 2, background noise either occurred in the first or second recording. Accuracy was higher when it occurred in the second. The overall results reveal that both speaking style and background noise can disrupt accuracy. Although there is a relationship between confidence and accuracy in all conditions, it is variable. The forensic implications of these findings are discussed.
Primate tails: Ancestral state reconstruction and determinants of interspecific variation in primate tail length
Authors: Sehner Sandro , Fichtel Claudia , Kappeler Peter M. 
Published: October 2018

AbstractObjectiveLiving primates vary considerably in tail length‐body size relation, ranging from tailless species to those where the tail is more than twice as long as the body. Because the general pattern and determinants of tail evolution remain incompletely known, we reconstructed evolutionary changes in relative tail length across all primates and sought to explain interspecific variation in this trait.MethodsWe combined data on tail length, head‐body length, intermembral index (IMI), habitat use, locomotion type, and range latitude for 340 species from published sources. We reconstructed the evolution of relative tail length to identify all independent cases of regime shifts on a primate phylogeny, using several methods based on Ornstein‐Uhlenbeck (OU) models. Accounting for phylogeny, we also examined the effects of habitat, locomotion type, distance from the equator and IMI on interspecific variation in tail length‐body size relation.ResultsPrimate tail length is not sexually dimorphic. A phylogenetic reconstruction allowing multiple optima explains the observed regime shifts best. During the evolutionary history of primates, relative tail length changed 50 times under an OU model. Specifically, relative tail length increased 26 and decreased 24 times. Most of these changes occurred among Old World primates. Among the variables tested here, interspecific variation in IMI and the difference between leaping and non‐leaping locomotion explained interspecific variation in relative tail length: Evolutionary decreases in relative tail length are generally associated with an increase in IMI and an absence of leaping behavior.ConclusionsRegime shifts for relative tail length in living primates occurred in concert with fundamental changes in IMI and a change from leaping to non‐leaping locomotion, or vice versa. Exceptions from this general pattern are linked to the presence of a prehensile tail or specialized foraging strategies. Thus, the primate tail appears to have evolved in functional coordination with limb proportions, presumably to assist body balance.
Morphometric analysis of shape differences in Windover and Point Hope archaic human mandibles
Authors: Boren Seth , Slice Dennis , Thomas Geoffrey 
Published: October 2018

AbstractObjectivesThe mandible can provide valuable information on both the life history and genetic makeup of Archaic human populations. The following analysis tests two hypotheses: (a) that there are significant differences in morphology in mandibular shape between the genders amongst Archaic North American Homo sapiens and (b) that there is a significant difference in variance in mandibular shape between Archaic Windover and Point Hope.Materials and MethodsA sample made from mandible specimens taken from both populations is subjected to Principal Component Analyses (PCA). The component scores from the PCAs are subjected to both a Multivariate Analysis of Covariance (mancova) and a general Multivariate Analysis of Variance (manova) to determine whether significant differences in variance exist between the sexes and the populations.ResultsThe mancova found that there are no significant interactions between the PC scores in population, sex, or size. Significant differences in variance were found between males and females and between the Windover and Point Hope populations.ConclusionsDifferences in variance observed between the populations are suspected to be due to differences in subsistence strategies and possibly non‐masticatory utilizations of teeth. Differences in variance between the genders are suspected to be genetic in origin.
Cilostazol decreases duration of spreading depolarization and spreading ischemia after aneurysmal subarachnoid hemorrhage
Authors: Sugimoto Kazutaka , Nomura Sadahiro , Shirao Satoshi , Inoue Takao , Ishihara Hideyuki , Kawano Reo , Kawano Akiko , Oka Fumiaki , Suehiro Eiichi , Sadahiro Hirokazu , Shinoyama Mizuya , Oku Takayuki , Maruta Yuichi , Hirayama Yuya , Hiyoshi Koichiro , Kiyohira Miwa , Yoneda Hiroshi , Okazaki Koki , Dreier Jens P. , Suzuki Michiyasu 
Published: October 2018

ObjectiveTraditionally, angiographic vasospasm (aVS) has been thought to cause delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). However, successful treatment of aVS alone does not result in improved neurological outcome. Therefore, there may be other potential causes of poor neurological outcome, including spreading depolarization (SD). A recent study showed beneficial effects of cilostazol on DCI and neurological outcome. The present prospective clinical trial and experimental study focused on effects of cilostazol on SDs.MethodsFifty aSAH patients were treated with clip ligation and randomly assigned to a cilostazol (n = 23) or control group (n = 27). Effects of cilostazol on DCI, aVS, and SDs, measured with subdural electrodes, were examined. The effect of cilostazol on SD‐induced perfusion deficits (spreading ischemia) was assessed in an aSAH‐mimicking model.ResultsThere was a trend for less DCI in the cilostazol group, but it did not reach our threshold for statistical significance (13.0% vs 40.0%, odds ratio = 0.266, 95% confidence interval [CI] = 0.059–1.192, p = 0.084). However, the total SD‐induced depression duration per recording day (22.2 vs 30.2 minutes, β = −251.905, 95% CI = −488.458 to −15.356, p = 0.043) and the occurrence of isoelectric SDs (0 vs 4 patients, β = −0.916, 95% CI = −1.746 to −0.085, p = 0.037) were significantly lower in the cilostazol group. In rats, cilostazol significantly shortened SD‐induced spreading ischemia compared to vehicle (Student t test, difference = 30.2, 95% CI = 5.3–55.1, p = 0.020).InterpretationRepair of the neurovascular response to SDs by cilostazol, as demonstrated in the aSAH‐mimicking model, may be a promising therapy to control DCI. Ann Neurol 2018;84:873–885
Germanium Wafers Possessing Facet‐Dependent Electrical Conductivity Properties
Authors: Hsieh Pei‐Lun , Lee An‐Ting , Chen Lih‐Juann , Huang Michael H. 
Published: October 2018

AbstractElectrical conductivity properties of Ge {100}, {110}, {111}, and {211} facets have been measured by breaking Ge (100) and (111) wafers to expose {110} and {211} surfaces and contacting the different facets with tungsten probes. Ge {111} and {211} faces are far more conductive than the already conductive Ge {100} and {110} faces, matching with recent density functional theory (DFT) predictions. Asymmetric I–V curves resembling those of p‐n junctions have been collected for the {110}/{111} and {110}/{211} facet combinations. The current‐rectifying effects stem from different degrees of surface band bending for the highly and less conductive faces and the direction of current flow. This work demonstrates that germanium wafers also possess facet‐dependent electrical conductivity responses that can be utilized in the fabrication of novel fin field‐effect transistors (finFET).