bluuebunny/crossref_metadata_2025_split huggingface dataset:
Taḥqīq vs. Taqlīd in the Renaissances of Western Early Modernity
Authors: Melvin-Koushki Matthew 
Published: May 2019

Abstract
This essay reviews a major new study of European Renaissance Arabist-humanist philology as it was actually practiced, humanist neoclassicizing anti-Arabism notwithstanding. While definitive and philologically magisterial, that study nevertheless falls prey structurally and conceptually to the very eurocentrism whose ideological-textual genesis it chronicles. Situating it within the comparative global early modern philologies framework that has now been proposed in the volume World Philology and the present journal is a necessary remedy—but only a partial one; for that framework too still obscures the multiplicity of specifically genetically Western early modernities, thus hobbling comparative history of philology. I therefore propose a new framework appropriate to the study of Greco-Arabo-Persian and Greco-Arabo-Latin as the two parallel and equally powerful philosophical-philological trajectories that together defined early modern Western—i.e., Hellenic-Abrahamic, Islamo-Judeo-Christian, west of South India—intellectual history: taḥqīq vs. taqlīd, progressivism vs. declinism.
But a broadened and more balanced analytical framework alone cannot save philology, much less Western civilization, from the throes of its current existential crisis: for we philologists of the Euro-American academy are fevered too by the cosmological ill that is reflexive scientistic materialism. As antidote, I prescribe a progressivist, postmodern return to early modern Western deconstructive-reconstructive cosmic philology as prerequisite for the discipline’s survival, and perhaps even triumph, in the teeth of totalitarian colonialist-capitalist modernity.
Where does Right-Wing Populism Succeed Sub-Nationally? Explaining Regional Variation within France
Authors: bin Zaid Hamzah , Joshi Devin K. 
Published: May 2019

AbstractWhile many scholars have studied how right-wing populist parties (RWPP) have recently increased their vote shares in national elections in many countries, fewer studies have assessed why some sub-national regions favor RWPP more than others. Addressing this gap in the literature, we analyze regional variation in voter support for one of Europe’s most successful RWPP, the Front National (FN) Party of France which recently made it to the second round of France’s 2017 presidential elections. Our research design examines electoral results across French regions between 1992 and 2017 through the lens of four case studies analyzing regions where the FN has been consistently popular, gained in popularity, declined in popularity, and been consistently unpopular. Comparing these diverse regional cases, our study concludes that regional unemployment, urban support, and to a lesser degree past voting behavior are significant demand-side factors behind regional voting for right wing populism.
Decentering the “White Working Class”
Authors: Nayak Meghana 
Published: May 2019

AbstractThis essay is a review of William Connolly’s Aspirational Fascim, and thus an extended analysis of the intersection of affect, race, class, and democracy. Connolly explores the role of negative affective contagion in mobilizing aggrieved white working class communities and argues for more inclusive pluralistic democracy and the use of positive affective democratic contagion to resist fascism. But he limits the radical potential of his argument because he focuses primarily on the white working class, thereby paying too little attention to the negative affective experiences of the trauma of racism. He should also interrogate not only fascist but also other types of negative affective support for Trump. I frame the essay as an invitation for productive engagement and conversation with Connolly.
Discovery of the genus Kudakrumia Krombein, 1979 (Hymenoptera: Mutillidae) in India and description of a new species
Authors: KUMAR GIRISH P. , LELEJ ARKADY S. , DAS DIPANWITA , RAVEENDRAN HANIMA K.P. , LOKTIONOV VALERY M. 
Published: May 2019

The Oriental genus Kudakrumia Krombein, 1979 is newly reported from India with two species: K. mirabilis Krombein, 1979 (Kerala) and K. rangnekari Girish Kumar & Lelej, sp. nov. (Goa, Kerala). A key to the Oriental genera and species of tribe Kudakrumiini is given.
The Influence of Dynamics and Emissions Changes on China’s Wintertime Haze
Authors: Sherman Peter , Gao Meng , Song Shaojie , Ohiomoba Patrick , Archibald Alex , McElroy Michael 
Published: May 2019

AbstractHaze days induced by aerosol pollution in North and East China have posed a persistent and growing problem over the past few decades. These events are particularly threatening to densely populated cities such as Beijing. While the sources of this pollution are predominantly anthropogenic, natural climate variations may also play a role in allowing for atmospheric conditions conducive to formation of severe haze episodes over populated areas. Here, an investigation is conducted into the effects of changes in global dynamics and emissions on air quality in China’s polluted regions using 35 simulations developed from the Community Earth Systems Model Large Ensemble (CESM LENS) run over the period 1920–2100. It is shown that internal variability significantly modulates aerosol optical depth (AOD) over China; it takes roughly a decade for the forced response to balance the effects from internal variability even in China’s most polluted regions. Random forest regressions are used to accurately model (R2 > 0.9) wintertime AOD using just climate oscillations, the month of the year, and emissions. How different phases of each oscillation affect aerosol loading is projected using these regressions. AOD responses are identified for each oscillation, with particularly strong responses from El Niño–Southern Oscillation (ENSO) and the Pacific decadal oscillation (PDO). As ENSO can be projected a few months in advance and improvements in linear inverse modeling (LIM) may yield a similar predictability for the PDO, results of this study offer opportunities to improve the predictability of China’s severe wintertime haze events and to inform policy options that could mitigate subsequent health impacts.
Impact of Surface Waves on Wind Stress under Low to Moderate Wind Conditions
Authors: Chen Sheng , Qiao Fangli , Jiang Wenzheng , Guo Jingsong , Dai Dejun 
Published: May 2019

AbstractThe impact of ocean surface waves on wind stress at the air–sea interface under low to moderate wind conditions was systematically investigated based on a simple constant flux model and flux measurements obtained from two coastal towers in the East China Sea and South China Sea. It is first revealed that the swell-induced perturbations can reach a height of nearly 30 m above the mean sea surface, and these perturbations disturb the overlying airflow under low wind and strong swell conditions. The wind profiles severely depart from the classical logarithmic profiles, and the deviations increase with the peak wave phase speeds. At wind speeds of less than 4 m s−1, an upward momentum transfer from the wave to the atmosphere is predicted, which is consistent with previous studies. A comparison between the observations and model indicates that the wind stress calculated by the model is largely consistent with the observational wind stress when considering the effects of surface waves, which provides a solution for accurately calculating wind stress in ocean and climate models. Furthermore, the surface waves at the air–sea interface invalidate the traditional Monin–Obukhov similarity theory (MOST), and this invalidity decreases as observational height increases.
DNA effects of low level occupational exposure to extremely low frequency electromagnetic fields (50/60 Hz)
Authors: Zendehdel Rezvan , Yu Il Je , Hajipour-Verdom Behnam , Panjali Zahra 
Published: May 2019

Aims: Exposure to extremely low frequency magnetic fields (ELF-MF) occurs from natural and artificial sources. Although ELF-MF has been classified as a suspected humans carcinogen agent by the International Agency for Research on Cancer, little is known of the effects of ELF-MF at lower exposure levels of the recommended range. In the present study, DNA damage in the peripheral blood cells of power line workers was investigated. Materials and Methods: Occupational exposure to ELF-MF in a power plant was measured using the National Institute for Occupational Safety and Health (NIOSH) manual. Single-strand breaks (SSBs) in DNA were evaluated in 29 male utility workers as the exposed population and 28 male support personnel as the control subjects using the comet assay. Effects of ELF-MF on subjects were evaluated using DNA percent in tails, tail length, olive length, and tail moment. Results: Occupational exposure levels to ELF-MF in the utility workers were less than the threshold limit values (TLV) recommended by the American Conference of Government Industrial Hygienist (ACGIH). The median value of the magnetic field at the working sites was 0.85 µT. Induction of DNA damage was observed for the exposed workers compared with the controls. Olive length, tail moment, and tail DNA percent increased significantly ( p < 0.05) in the utility workers. Conclusions: Exposure to ELF-MF at levels less than the ACGIH exposure limit can produce DNA strand breaks.
Acute pectoralis major tears in active duty US military personnel: Midterm outcomes of repairs performed in the forward-deployed setting
Authors: Salazar Dane , Davis William , Shakir Irshad , Joe Keith , Choate W Steven 
Published: May 2019

Purpose: To report midterm outcomes of a series of acute pectoralis major tears repaired surgically in the deployed setting in active duty military personnel. Methods: Analysis of acute pectoralis major tears treated at one expeditionary medical treatment facility during a 4-month time frame. Results: Nine male patients with a mean age of 32 years (23–52) were diagnosed with tears; seven underwent operative fixation in the forward deployed setting. All injuries occurred during bench press, with the dominant upper extremity involved 56% of the time. With an average final follow-up of 4.1 years, the mean disabilities of the arm shoulder and hand score was 35.71 (range 31–41) and the mean American shoulder and elbow surgeons score was 90.71 (range 87–95). All personnel returned to their preinjury jobs with an average return to full preinjury function occurring at 7 months (range 4.5–10.5 months) in the operative group. Conclusions: Combat-deployed active duty US military personnel likely represent a high-risk population for this injury. Our study demonstrates that with at least 4 years of follow-up, surgical repair with a trough and trans-osseous repair technique was technically feasible and clinically successful in the deployed setting. Although this treatment may be considered in rare individual cases moving forward, due to the lengthy postoperative restrictions, inability to return back to duty in a timely manner, and lengthy rehabilitation, we no longer recommend this surgery be performed in theater.
Pairwise visual comparison of small RNA secondary structures with base pair probabilities
Authors: Léger Serge , Costa Maria Beatriz Walter , Tulpan Dan 
Published: May 2019

Abstract
Background
Predicted RNA secondary structures are typically visualized using dot-plots for base pair binding probabilities and planar graphs for unique structures, such as the minimum free energy structure. These are however difficult to analyze simultaneously.

Results
This work introduces a compact unified view of the most stable conformation of an RNA secondary structure and its base pair probabilities, which is called the Circular Secondary Structure Base Pairs Probabilities Plot (CS2BP2-Plot). Along with our design we provide access to a web server implementation of our solution that facilitates pairwise comparison of short RNA (and DNA) sequences up to 200 base pairs. The web server first calculates the minimum free energy secondary structure and the base pair probabilities for up to 10 RNA or DNA sequences using RNAfold and then provides a two panel comparative view that includes CS2BP2-Plots along with the traditional graph, planar and circular diagrams obtained with VARNA. The CS2BP2-Plots include highlighting of the nucleotide differences between two selected sequences using ClustalW local alignments. We also provide descriptive statistics, dot-bracket secondary structure representations and ClustalW local alignments for compared sequences.

Conclusions
Using circular diagrams and colour and weight-coded arcs, we demonstrate how a single image can replace the state-of-the-art dual representations (dot-plots and minimum free energy structures) for base-pair probabilities of RNA secondary structures while allowing efficient exploration and comparison of different RNA conformations via a web server front end. With that, we provide the community, especially the biologically oriented, with an intuitive tool for ncRNA visualization.
Web-server:https://cs2bp2plot.cluster.gctools.nrc.ca/
Discovery of Noncancer Drug Effects on Survival in Electronic Health Records of Patients With Cancer: A New Paradigm for Drug Repurposing
Authors: Wu Yonghui , Warner Jeremy L. , Wang Liwei , Jiang Min , Xu Jun , Chen Qingxia , Nian Hui , Dai Qi , Du Xianglin , Yang Ping , Denny Joshua C. , Liu Hongfang , Xu Hua 
Published: May 2019

PURPOSEDrug development is becoming increasingly expensive and time consuming. Drug repurposing is one potential solution to accelerate drug discovery. However, limited research exists on the use of electronic health record (EHR) data for drug repurposing, and most published studies have been conducted in a hypothesis-driven manner that requires a predefined hypothesis about drugs and new indications. Whether EHRs can be used to detect drug repurposing signals is not clear. We want to demonstrate the feasibility of mining large, longitudinal EHRs for drug repurposing by detecting candidate noncancer drugs that can potentially be used for the treatment of cancer.PATIENTS AND METHODSBy linking cancer registry data to EHRs, we identified 43,310 patients with cancer treated at Vanderbilt University Medical Center (VUMC) and 98,366 treated at the Mayo Clinic. We assessed the effect of 146 noncancer drugs on cancer survival using VUMC EHR data and sought to replicate significant associations (false discovery rate < .1) using the identical approach with Mayo Clinic EHR data. To evaluate replicated signals further, we reviewed the biomedical literature and clinical trials on cancers for corroborating evidence.RESULTSWe identified 22 drugs from six drug classes (statins, proton pump inhibitors, angiotensin-converting enzyme inhibitors, β-blockers, nonsteroidal anti-inflammatory drugs, and α-1 blockers) associated with improved overall cancer survival (false discovery rate < .1) from VUMC; nine of the 22 drug associations were replicated at the Mayo Clinic. Literature and cancer clinical trial evaluations also showed very strong evidence to support the repurposing signals from EHRs.CONCLUSIONMining of EHRs for drug exposure–mediated survival signals is feasible and identifies potential candidates for antineoplastic repurposing. This study sets up a new model of mining EHRs for drug repurposing signals.
Regulation of Notch signaling by the chromatin-modeling protein Hat-trick
Authors: Singh Ankita , Paul Maimuna S. , Dutta Debdeep , Mutsuddi Mousumi , Mukherjee Ashim 
Published: May 2019

ABSTRACT
Notch signaling plays a pleiotropic role in a variety of cellular processes, including cell fate determination, differentiation, proliferation and apoptosis. The increasingly complex regulatory mechanisms of Notch signaling account for the many functions of Notch during development. Using a yeast two-hybrid screen, we identiﬁed the Drosophila DNA-binding protein Hat-trick (Htk) to be an interacting partner of Notch-intracellular domain (Notch-ICD); their physical interaction was further validated by co-immunoprecipitation experiments. htk genetically interacts with Notch pathway components in trans-heterozygous combinations. Loss of htk function in htk mutant somatic clones resulted in the downregulation of Notch targets, whereas its overexpression caused ectopic expression of Notch targets, without affecting the level of the Notch protein. In the present study, immunocytochemical analyses demonstrate that Htk and overexpressed Notch-ICD colocalize in the same nuclear compartment. Here, we also show that Htk cooperates with Notch-ICD and Suppressor of Hairless to form an activation complex and binds to the regulatory sequences of Notch downstream targets such as Enhancer of Split complex genes, to direct their expression. Together, our results suggest a novel mode of regulation of Notch signaling by the chromatin-modeling protein Htk.
Single cell expression analysis reveals anatomical and cell cycle-dependent transcriptional shifts during heart development
Authors: Li Guang , Tian Lei , Goodyer William , Kort Eric J. , Buikema Jan W. , Xu Adele , Wu Joseph C. , Jovinge Stefan , Wu Sean M. 
Published: May 2019

ABSTRACT
The heart is a complex organ composed of multiple cell and tissue types. Cardiac cells from different regions of the growing embryonic heart exhibit distinct patterns of gene expression, which are thought to contribute to heart development and morphogenesis. Single cell RNA sequencing allows genome-wide analysis of gene expression at the single cell level. Here, we have analyzed cardiac cells derived from early stage developing hearts by single cell RNA-seq and identified cell cycle gene expression as a major determinant of transcriptional variation. Within cell cycle stage-matched CMs from a given heart chamber, we found that CMs in the G2/M phase downregulated sarcomeric and cytoskeletal markers. We also identified cell location-specific signaling molecules that may influence the proliferation of other nearby cell types. Our data highlight how variations in cell cycle activity selectively promote cardiac chamber growth during development, reveal profound chamber-specific cell cycle-linked transcriptional shifts, and open the way to deeper understanding of pathogenesis of congenital heart disease.
Inflated Reputations: Uncertainty, Leniency, and Moral Wiggle Room in Trader Feedback Systems
Authors: Bolton Gary E. , Kusterer David J. , Mans Johannes 
Published: May 2019

The reputation information provided by market feedback systems tends to be compressed in the sense that reliable and unreliable sellers have similar feedback scores. The experiment presented here features a market in which what a buyer receives is a noisy signal of what was actually sent. We focus on the influence the noise has on endogenously given feedback. The attributional uncertainty creates room for leniency in feedback giving. We find that buyer leniency reduces the informativeness of the feedback system and, in combination with uncertainty, diminishes seller trustworthiness. With a noisy signal, buyers pay about the same prices but get significantly less. This paper was accepted by Uri Gneezy, behavioral economics.
State Space Based Linear Controller Design for the Inverted Pendulum
Authors: Kuczmann Miklós 
Published: May 2019

In a previous survey paper the detailed PID controller design to stabilize the inclination angle as well as the horizontal movement of an inverted pendulum system has been presented. In this paper the linear controller design based on the state space representation is shown step by step. Pendulum model is based on EulerLagrange modeling, and the nonlinear state space model is linearized in the unstable upward position, finally pole placement by Ackermann formula and Bass–Gura equation, moreover linear quadratic optimal control are presented. The pendulum has been inserted into a virtual reality laboratory, which is suitable to use in model based control teaching.
KOORDINASI SETTING RELAI ARUS LEBIH PADA INCOMING 2 KUDUS TERHADAP OUTGOING KUDUS 5 DAN 6 YANG MENGGUNAKAN JARINGAN DOUBLE CIRCUIT DI GI 150 KV KUDUS
Authors: Wardani Sartika Kusuma , Subali Subali 
Published: May 2019

Sartika Kusuma Wardani, Subali, in paper coordination of flow over relay setting in incoming 2 kudus to outgoing 5 and 6 using double circuit network on GI 150 KV kudus explain that PT PLN make every effort to improve service to customers , one of them by increasing the reliability of the distribution of electrical energy . Reliability of the distribution network is very important for both consumers and PLN. One measure of the reliability of the system / network is a factor SAIDI (System Average Interruption Duration Index) and SAIFI (System Average Interruption Frequency Index). Steps that have been done one way to minimize the possibility of interference is by installing protective devices on medium voltage networks. However, installation of protection equipment is not enough if the relay setting coordination between the incoming and outgoing imprecise. In fact in recent months, an interruption in the feeder distribution network which affects the incoming relay tripnya due to failure of the feeder protection system. One of the events that have happened several times is the same disorder in a double feeder circuit (network supplied from a single source by using two networks ( two feeder ) were included in the bus and in 1 pole) and holy 5 and 6 which causes the incoming PMT trip. It is very risky to happen, because the resulting trip relays at all incoming feeder that gets supply voltage of the incoming. So it takes coordination of overcurrent relay settings right so that the incidence of the incoming trip Sacred 2 does not happen again . Keywords: distribution, protection, relay settings, incoming, outgoing