bluuebunny/crossref_metadata_2025_split huggingface dataset:
Public Health Data Exchange Through Health Information Exchange Organizations: National Survey Study
Authors: Rosenthal Sarah , Adler-Milstein Julia , Patel Vaishali 
Published: November 2024

Abstract

Background
The COVID-19 pandemic revealed major gaps in public health agencies’ (PHAs’) data and reporting infrastructure, which limited the ability of public health officials to conduct disease surveillance, particularly among racial or ethnic minorities disproportionally affected by the pandemic. Leveraging existing health information exchange organizations (HIOs) is one possible mechanism to close these technical gaps, as HIOs facilitate health information sharing across organizational boundaries.

Objective
The aim of the study is to survey all HIOs that are currently operational in the United States to assess HIO connectivity with PHAs and HIOs’ capabilities to support public health data exchange.

Methods
Drawing on multiple sources, we identified all potential local, regional, and state HIOs that were operational in the United States as of March 1, 2022. We defined operational as HIOs that facilitated exchange between at least 2 independent entities. We fielded a survey among our census list of 135 HIOs in January-July 2023. The survey confirmed HIO status as well as captured organizational demographics and current and potential support for PHAs. We report descriptive statistics on HIO demographics and connectivity with PHAs. We also include results on services and data available to support PHAs, funding sources to support public health reporting, and barriers to public health reporting. Of the 135 potential HIOs that received the survey, 90 met our definition of an HIO, and 77 completed the survey, yielding an 86% response rate.

Results
We found that 66 (86%) of HIOs in 45 states were electronically connected to at least 1 PHA, yielding 187 HIO-PHA connections across all HIOs. Among HIOs connected to PHAs, the most common type of public health reporting supported by HIOs was immunization registry (n=39, 64%), electronic laboratory result (n=37, 63%), and syndromic surveillance (n=34, 61%). In total, 58% (n=38) of HIOs connected to PHAs provided data to address COVID-19 information gaps, and an additional 30% (n=20) could do so. The most common types of data provided to PHAs were hospitalization information (n=54, 93%), other demographic data (n=53, 91%), health information (eg, chronic health conditions; n=51, 88%), and hospital laboratory results (n=51, 88%). A total of 64% (n=42) of HIOs provided at least 1 type of data analytic service to PHAs to support COVID-19 pandemic response efforts. Top HIO reported barriers to support PHA activities included limited PHA funding (n=21, 32%) and PHAs’ competing priorities (n=15, 23%).

Conclusions
Our results show that many HIOs are already connected to PHAs and that they are assuming an emerging role to facilitate public health reporting. HIOs are well-positioned to provide value-added support for public health data exchange and address PHAs’ information gaps, as ongoing federal efforts to modernize public health data infrastructure and interoperability continue.
COMO O PENTECOSTALISMO CRESCE
Authors: Reinhardt Bruno 
Published: November 2024

Cristãos pentecostais em Gana exibem intensidades e estilos heterogêneos de devoção. Em contraste, representações acadêmicas têm destacado quase que exclusivamente suas versões públicas e intercessórias, eventualmente qualificando-as como “mágicas" e recorrendo a teorias da privação para explicar o vertiginoso crescimento desta espiritualidade nas últimas décadas. Neste artigo, examino as rotinas devocionais cultivadas por cristãos "convictos", reconhecidos por seus pares como sujeitos “orantes” [prayerful/mpaebɔni]. Inspirado por autores que sublinham os componentes pedagógicos das tradições religiosas, como Mauss e Asad, investigo etnograficamente a ética embutida na oração pentecostal em Gana. Argumento que, sob esta ótica, a oração carismática não é um objeto discernível de investigação, mas um campo contínuo de problematização ética impulsionado por duas modalidades humanas de dispêndio físico-moral: o hábito e a antecipação. Concluo enfatizando como a atenção aos "bens internos" da oração pentecostal nos permite integrar o problema da vulnerabilidade e do sofrimento nos projetos religiosos, ao invés de reduzi-lo a forças causais externas.
Educação Física Cultural
Authors: De Souza Anna Carolina Carvalho , Garcia Neira Marcos , Costa Telles Silvio de Cassio 
Published: November 2024

O currículo cultural se apresenta enquanto proposta que busca superar as práticas hegemônicas e eurocêntricas, reconhecer e valorizar as diferenças e problematizar as desigualdades e injustiças com vistas a contribuir com a formação de sujeitos solidários. Para tanto, os professores que afirmam colocá-lo em ação são agenciados por determinados princípios ético-políticos, o que os leva a tematizar determinadas práticas corporais mediante encaminhamentos pedagógicos singulares. A fim de identificar as percepções acerca dessa proposta, o presente artigo submete ao confronto com a teoria curricular cultural, os dados gerados a partir de entrevistas narrativas feitas com professores que atuam numa instituição pública cujo projeto político pedagógico se alinha a essa vertente de ensino. A investigação reconhece que, de acordo com as falas docentes, houve mudança da percepção estudantil sobre as práticas corporais. Os estudantes puderam encontrar nesse espaço educacional o reconhecimento de suas identidades, tendo maior possibilidade de vivenciar experiências inéditas e diversificadas que promoveram maior representatividade, o que gerou provável identificação com as práticas corporais tematizadas.
Formação docente em Educação Física
Authors: Miranda Pereira Virginia , Christina Campos Figueiredo Zenólia , Eduardo Caparroz Francisco 
Published: November 2024

Este ensaio propõe problematizar outras formas de pensar os processos de formação e a constituição da docência de professores de Educação Física que atuam nos diferentes níveis de ensino. Busca traçar entrelaçamento e diálogo interseccionais entre três campos: Arte, Cultura e Educação Física, com vistas a trazer novas perspectivas à formação e ao trabalho docente. Reflete a arte, a cultura e as experiências estéticas como potencialidades capazes de provocar o docente a lançar mão, em sua formação e na docência, de criações e objetivações estratégicas para lidar com o conhecimento e com o cotidiano escolar.
Phytochemical profile, in-vitro antioxidant, anti-diabetic and anti- inflammatory activities of traditionally used Euphorbia hirta (L.) growing under wild conditions of Northern Punjab
Authors: Sharma Arun dev , Kaur Inderjeet , Chuhan Amrita , Kumar Sunny , Singh Narveer 
Published: November 2024

Euphorbia spp., are the widely distributed and traditionally used herbal plants due to their diverse biological activities. The aim of this study was comparative extraction of secondary metabolites with different solvents like acetone, ethanol, methanol and water and assessment of their biological activities from Euphorbia hirta L. Plant extracts from dried powder were prepared in different solvents. Phytochemicals like: phenolics, flavonoids and condensed tannins were estimated using standard assays. GC-FID studies were conducted to find out the presence of various bioactive compounds. Fingerprint analysis using UV, FT-IR and fluorescent spectroscopy was also conducted. Antioxidant activities using various assays, anti-diabetic and anti-inflammatory potential of extracts were evaluated. Fingerprint analysis using, UV-, FT-IR and fluorescent spectroscopy specified the occurrence of adequate level of polyphenolics in all solvent extracts. Amongst all solvents acetone gave higher yield of polyphenolics in-toto. GC-FID analysis of acetone extracts depicted the presence of bioactive compounds like major 1-naphthalenepropanol. All extracts depicted enough level of antioxidant activities viz: DPPH, ABTS, hydroxyl radical, iron chelating and lipid peroxidation, but in a solvent dependent manner. Adequate anti-diabetic activity and anti-inflammatory activities were also observed in extracts. The results specified that by using suitable solvents bioactive compounds from Euphorbia species can be extracted and used as therapeutic agents having potential biological activities.
Development and validation of a new analytical method based on UV-visible spectroscopy for quantification of ceftaroline fosamil in powder for injection
Authors: Machioli Lilian F. , Rosa Gabriele , Carlos Graciela , Mendez Andreas Sebastian Loureiro 
Published: November 2024

Quantification of drugs is an essential part for ensuring quality, safety and efficacy of pharmaceutical formulations. For this, validated methods must be used in order to guarantee analytical reliability during monitoring in clinical studies and quality control. In the present study, we aim to develop a reliable, accurate, accessible and rapid UV-VIS spectrophotometry method for quantification of ceftaroline fosamil in powder for intravenous administration. Each analyzed solution was prepared individually and the only reagent used was Milli-Q water, as a solvent, making the method eco-friendly. The absorbances were measured at 242 nm, the peak absorbance found for the drug. The developed method was validated according to ICH and ANVISA guidelines, proving to be specific and demonstrating good linearity in the concentration range of 5 μg.mL-1 to 15 μg.mL-1, with determination (r2) and correlation coefficients (r) equal to 0.9999. The limits of detection and quantification found were acceptable (0.51 μg.mL-1 and 1.55 μg.mL-1, respectively). The method exhibited excellent intermediate precision and repeatability, with relative standard deviation values of 0.87% and 0.98%, respectively. Furthermore, the method’s accuracy was confirmed, showing a mean recovery of 100 ± 2.67%. Additionally, the robustness was assayed and confirmed using Plackett-Burmann design. In conclusion, the method can easily be applied for routine quality control analysis.
Docência compartilhada como princípio basilar na área dos Anos Iniciais do Colégio de Aplicação/UFRGS:
Authors: De Souza Mariana Venafre Pereira , Schander Sofia 
Published: November 2024

O artigo tem como objetivo principal historicizar a docência compartilhada na área dos Anos Iniciais do Colégio de Aplicação/UFRGS (CAp/UFRGS), tomando-a como um princípio basilar da prática pedagógica. Para tanto, nos valemos de entrevista, observação participante e leitura de documentos produzidos pela referida área como ferramentas metodológicas para tecer análises a respeito do tema. Além disso, contextualizamos a docência compartilhada a partir do relato de experiência de uma turma de primeiro ano do Ensino Fundamental no ano de 2023 do CAp/UFRGS com a finalidade de demonstrar as potencialidades do trabalho diante do desafio de turmas heterogêneas que precisam de mediações que se encaminham para a diferenciação do ensino. Essa prática foi gestada para garantir a permanência e a qualidade de atendimento aos estudantes e famílias em seus aspectos sociais, econômicos, raciais, culturais, emocionais e cognitivos; construindo, assim, uma escola mais inclusiva. As professoras relataram que, a partir da docência compartilhada, ao mesmo tempo em que as turmas passaram a ter avanços significativos nas aprendizagens, as próprias professoras passaram a ter mais tempo de qualidade e maior assertividade para gerir situações de conflito; vendo, assim, potencializada a reflexão sobre sua prática e a humanização das condições de trabalho.
Dazzle vs. protection - visualizing the optimum laser eye protection for laser dazzle suppression
Authors: Williamson Craig , Freeman Oliver 
Published: November 2024

To aid the evaluation and selection of laser eye protection (LEP), a model has been developed to allow for the colouration effects of laser eye protection to be visualised against their laser dazzle suppression capabilities. This is achieved through the implementation of a colour appearance model (CIECAM02) and a modified version of the CIE general disability glare equation, which allows a simple way of visualising the effects caused by the addition of laser eye protection. The model is able to use any digital image as a background scene, allowing for real-world visualisations of LEP and dazzle over a broad range of scenarios. Further details are available in: Oliver J. Freeman, Craig A. Williamson, “Visualising the trade-offs between laser eye protection and laser eye dazzle,” Journal of Laser Applications 32, 012008 (2020); https://doi.org/10.2351/1.5132601
© Crown copyright (2022), Dstl. This material is licensed under the terms of the Open Government Licence except where otherwise stated. To view this licence, visit http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk.
Autocracy as actual historical power
Authors: Smolin M. B. 
Published: November 2024

The article is devoted to the historical term “Autocracy” in the interpretation of Professor P.E. Kazansky, as an independent, non-derivative, having the only basis in the will of God itself, and therefore in earthly reality, which was the dominant force in the state. This force is not only legally supreme, but also, in fact, socially the strongest, without which domination would be impossible.In his concept, Professor P.E. Kazansky argues that the autocrat was not only a legal sovereign, as he possessed the rights of supreme power legally enshrined in the Basic Laws of the state, but was also a de facto sovereign, who historically possessed the dominant force in society.
Cross-sectional survey of rural and nonrural veterinarians indicates similarities in intent to stay or leave practice and differences in community attachment and satisfaction
Authors: Banse Heidi E. , Hunter Anjel Stough , Althouse Gary , Anderson Stacy , Boudreaux Bonnie , Chaney Kristin , Garden Oliver A. , Navarre Christine , Roush James K. , Schleining Jennifer A. , Seneca Eric , Shivley Jake , Ward Jessica , Raczkoski Brandon 
Published: November 2024

Abstract

OBJECTIVE
The primary objective was to identify veterinary workforce characteristics and factors contributing to staying in or leaving a veterinary practice. A secondary objective was to compare workforce characteristics and factors related to retention between survey respondents working in rural versus nonrural areas.

METHODS
Veterinarians were surveyed via a questionnaire distributed with the use of a state veterinary medical association listserv or veterinary program alumni listserv from February 2022 to January 2023 and social media postings on X (formerly known as Twitter) and Facebook in April 2022.

RESULTS
There were 2,195 respondents. Most respondents were in small animal practice (78%) in a nonrural environment (76%). Overall, 78% of respondents indicated intent to stay in their current practice, with no difference between veterinarians in rural versus nonrural practices. There was the perception of need for veterinarians both short-term (1 year) and long-term (10 years). Practitioners were generally satisfied with and connected to their communities. Rural practitioners more frequently reported work weeks of > 40 hours per week and a greater amount of time spent on call (weekdays and weekends). Nonrural practitioners were generally more satisfied with their community amenities, whereas rural practitioners were more attached to their communities.

CONCLUSIONS
Veterinarians perceive the need for additional practitioners in the workforce both short-term and long-term in all environments. Despite longer work hours reported in rural environments, intent to stay in or leave a practice did not differ between rural and nonrural veterinarians.

CLINICAL RELEVANCE
Veterinarians perceive a need for practitioners across species and scope of practice. Community attachment may be an important factor to leverage when considering training veterinary students and recruiting veterinary graduates into rural practice.
Inverse Element for Surreal Number
Authors: Pąk Karol 
Published: November 2024

Summary
Conway’s surreal numbers have a fascinating algebraic structure, which we try to formalise in the Mizar system. In this article, building on our previous work establishing that the surreal numbers fulfil the ring properties, we construct the inverse element for any non-zero number. For that purpose, we formalise the definition of the inverse element formulated in Section Properties of Division of Conway’s book. In this way we show formally in the Mizar system that surreal numbers satisfy all nine properties of a field.
Methyltransferase-like 14 promotes the tumorigenesis and proliferation of pancreatic cancer cells through myc proto-oncogene signaling pathway
Authors: Li Junru , Wang Peng , Liu Fei , Li Yuanyuan , Wu Youyou , Wang Fengbo , Du Jundong 
Published: November 2024

Objective:
Pancreatic cancer is characterized by low survival rate and rapid deterioration. Methyltransferase-like 14 (METTL14), as N6-methyladenosine (m6A) methyltransferase, is closely related to tumor progression. The purpose of this study is to look into how METTL14 affects pancreatic cancer tumorigenesis, cell division, and apoptosis.

Material and Methods:
We examined and contrasted the levels of METTL14 protein and messenger RNA expression in human pancreatic ductal cells and human pancreatic cancer cells. After silencing or upregulating METTL14, the proliferative ability, migration ability, and cell apoptosis of pancreatic tumor cells was detected by colony-forming assay, wound scratch healing assay, cell counting kit 8 assay, and terminal deoxynucleotidyl transferasemediated 2’-deoxyuridine 5’-triphosphate-biotin nick end labeling assay. Following the use of c-Myc inhibitor (10058-F4), western blot analysis was carried out to investigate the key factor expression and c-Myc signaling pathway activation status.

Results:
METTL14 was preferentially expressed in human pancreatic cancer cells PANC-1 and SW1990 than in human normal pancreatic duct cells human pancreatic nestin-expressing cells (HPNE) (P < 0.001). Overexpression of METTL14 increased the tumorigenic and proliferative ability of pancreatic cancer cells. Overexpression of METTL14 decreased apoptosis rate. Western blot assay showed that nucleus b-catenin increased when METTL14 was overexpressed, and nucleus b-catenin decreased when METTL14 was silenced in PANC-1 cell (P < 0.01). The protein expression of other key factors, such as c-Myc, matrix metalloproteinase (MMP)-9, and MMP-2, were also affected. The use of c-Myc inhibitor (10058-F4) on the basis of OE-METTL14 reversed the effect of the overexpression of METTL14 on promoting the tumorigenesis and cell proliferation of pancreatic cancer cell lines PANC-1 and SW1990.

Conclusion:
METTL14 promoted the tumorigenesis and proliferation of pancreatic cancer cells by the c-Myc signaling pathway.
Fibronectin type III domain containing protein 5/irisin alleviated sepsis-induced acute kidney injury by abating ferroptosis through the adenosine 5'-monophosphate-activated protein kinase/nuclear factor erythroid-2-related factor 2 signaling pathway
Authors: Gui Shenghao , Zhu Chaochao , Lu Yunfeng 
Published: November 2024

Objective:
Ferroptosis has been described in association with acute kidney injury (AKI)-induced sepsis. Fibronectin type III domain containing protein 5 (FNDC5)/irisin plays a crucial role in renal protection. The objective of this study was to investigate whether FNDC5/irisin is involved in AKI-induced sepsis by modulating ferroptosis, and the molecular mechanisms that may be involved.

Material and Methods:
A sepsis-induced AKI model was built in vivo and in vitro through lipopolysaccharide (LPS) intervention. FNDC5, adenosine 5'-monophosphate-activated protein kinase (AMPK), phospho-AMPK (p-AMPK), nuclear factor erythroid-2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), glutathione peroxidase 4 (GPX4), and acyl-CoA synthetase long-chain family member 4 (ACSL4) concentrations in cells and mouse kidney tissues were appraised by Western blot. Pro-inflammatory cytokines concentrations in cell supernatants and mouse kidney tissues were appraised by enzyme-linked immunosorbent assay. Fe2+ concentration in cells and mouse kidney tissue was appraised by kit. The apoptosis rate of cells and mouse kidney tissue was measured by flow cytometry. Automatic biochemical analyzer was to test serum creatinine (SCr) and blood urea nitrogen (BUN). The kidney tissue sections from each groups were observed by hematoxylin and eosin staining.

Results:
LPS abated FNDC5 concentration in human kidney-2 cells and mouse kidney tissue (P < 0.001). Overexpression of FNDC5 can abated proinflammatory cytokines concentrations in cells and mouse kidney tissue (P < 0.01). Meanwhile, overexpression of FNDC5 can boost GPX4 protein concentration, abate ACSL4 protein, and abate Fe2+ concentration in cells and mouse kidney tissues (P < 0.05). In addition, the overexpression of FNDC5 can reduce the rate of apoptosis (P < 0.01). In vivo experiments showed that FNDC5 overexpression reduced serum BUN and SCr concentrations and alleviated pathological damage in the mouse renal tissues (P < 0.05) and exhibited a certain renal protective effect. FNDC5 overexpression can boost p-AMPK/AMPK, Nrf2, and HO-1 protein concentrations (P < 0.01).

Conclusion:
FNDC5/irisin improves sepsis-induced acute renal injury by abating ferroptosis through the AMPK/Nrf2 signaling pathway.
Sesame: A viable economic alternative for off-season double cropping systems in Mato Grosso, Brazil
Authors: Christo Bruno Fardim , Lorenzoni Rodrigo Monte , Marques Junior Edilson , Nóia Júnior Rogerio De Souza , Pagotto Luís Otávio 
Published: November 2024

This study investigates the economic feasibility of sesame (Sesamum indicum L) cultivation as an alternative to off-season double cropping systems in Mato Grosso, Brazil, focusing on the period from 2016 to 2023. By employing a combination of qualitative and quantitative methodologies, it scrutinizes production costs, profitability, and climatic risks associated with both crops. The findings reveal that sesame cultivation entails consistently lower production costs, yielding superior margins, and exhibiting remarkable resilience against economic and climatic adversities compared to off-season maize. Despite minor fluctuations, sesame demonstrates stability in profitability, mitigating the impact of climatic risks on farmers' financial outcomes. This underscores sesame's potential to enhance farmers' financial resilience and bolster Brazil's position in global agricultural markets amidst climatic uncertainties. Furthermore, the study highlights sesame's role in promoting sustainable agricultural practices and enhancing food security. Through its comprehensive analysis, this research not only underscores the economic advantages of sesame cultivation but also emphasizes the importance of considering climatic risks in agricultural decision-making. By offering invaluable insights into the economic viability of sesame cultivation amidst climatic challenges, this study contributes to informed policy formulation and agricultural practice refinement in Brazil.