bluuebunny/crossref_metadata_2025_split huggingface dataset:
3237 CMV Gastric Ulcer in a Patient With Pauci Immune Cresenteric Glomerulonephritis on Rituximab: A Rare Combination
Authors: Ishtiaq Rizwan , Wilhelm Darlene M. , Ahmad Sumair 
Published: October 2019

INTRODUCTION:
CMV infections are asymptomatic in immunocompetent patients but in immunocompromised patients, CMV have varying manifestations depending on their location. Patient who are organ transplant recipients, taking immunosuppressive therapy for a long time are at increased risk of CMV infections. CMV induced gastric ulcer is very rare but many cases have been reported in the literature. No case describing association between CMV related gastric ulcer and glomerulonephritis has not been reported in the literature so far.

CASE DESCRIPTION/METHODS:
In this manuscript, we describe a case of pauci immune cresenteric glomerulonephritis in a patient who was on rituximab and long-term steroid therapy and found to have CMV related gastric ulcer. The association of small vessel vasculitis and CMV related gastrointestinal infection has not been studied in the literature.

DISCUSSION:
Pauci immune cresenteric glomerulonephritis is a subtype of rapidly progressive glomerulonephritis manifested by continuous loss of renal functions with features of dysmorphic red blood cells and glomerular proteinuria. Treatment of such condition is a genetically engineered chimeric murine/human monoclonal IgG1 kappa antibody directed against the CD20 antigen known as Rituximab. We also discussed the pathogenesis of CMV induced gastric ulcer after rituximab therapy. This case emphasizes the importance of opportunistic infections in glomerulonephritis patients and raises the awareness that glomerunephritis patients are at increased risk of opportunistic infections as well. Rituximab was considered to be a safer drug but over the years, the incidence if opportunistic infections in patients on rituximab has been increasing.
3245 A Pressing Matter: A Case of Polycystic Liver Disease Resulting in Gastric Outlet Obstruction
Authors: Bergagnini Isabella , Nocerino Angelica , Ivanina Elena 
Published: October 2019

INTRODUCTION:
Polycystic liver disease (PLD), a rare autosomal dominant genetic disorder, is characterized by the progressive development of multiple hepatic cysts. Largely, patients remain asymptomatic however <5% develop complications related to cyst formation, including perforation, hemorrhage, infection, and obstruction. Here we depict a case of PLD presenting as gastric outlet obstruction (GOO).

CASE DESCRIPTION/METHODS:
A 62-year-old man with a history of alcohol abuse, alcoholic pancreatitis presented with intractable diffuse abdominal pain seven days prior to admission. CT abdomen demonstrated large ascites and innumerable hepatic cysts with findings concerning for GOO. The patient underwent a diagnostic paracentesis, with ascitic studies consistent with spontaneous bacterial peritonitis (SBP) which was treated with a course of antibiotics. He then underwent an EGD which revealed severe esophagitis and fluid and food particles in the esophagus and stomach. Prior to repeat EGD, his stomach was decompressed with a nasogastric tube and he was intubated for airway protection given concern for aspiration. The second EGD revealed a previously noted pyloric stricture which was stented, providing symptomatic relief. The patient's hospital course was also notable for septic shock secondary to ESBL Klebisella pneumoniae and hemorrhagic gastritis resulting in acute blood loss anemia requiring multiple RBC transfusions. Ultimately, he was made DNR/DNI and expired 30 days after admission.

DISCUSSION:
PLD is characterized by the development of multiple hepatic cysts. It presents as part of one of two genetically distinct disease entities, isolated polycystic liver disease and as an extrarenal manifestation in polycystic kidney disease. Diagnosis is made via imaging studies, including ultrasound, CT, or MRI with the latter two being the most sensitive modalities. The majority of patients (>80%) remain asymptomatic, only requiring clinical, laboratory, and radiographic surveillance. However, when symptoms arise, they typically are secondary to compression of adjacent structures often resulting in abdominal pain, early satiety, and even jaundice. Treatment remains dependent on underlying etiology with a focus on palliation. As only a minority exhibit symptoms, GOO secondary to PLD is rarely reported in the literature. We present this case to raise awareness of this rare disease and this uncommon complication to help aid prompt diagnosis and management of GOO.
Prevention and treatment of late complications of diabetes in children and adolescents
Authors: Kasatkina E. P. , Odud E. A. , Sichinava I. G. , Sivous G. I. , Doll S. E. 
Published: October 2019

The most important problem of modern clinical diabetology is the prevention and treatment of late complications of diabetes.
Until recently, it was believed that the prevention and treatment of diabetic microvascular lesions was mainly a problem for endocrinologists. However, to date it has been reliably established that diabetic complications not only develop more often in patients with insulin-dependent diabetes mellitus (IDDM) in childhood, but are also widespread among children and especially adolescents [1, 2].
Evaluation of the effectiveness of treatment with thyroxine and iodotyrox drugs in patients with diffuse non-toxic goiter in Moscow
Authors: Tomashevsky I. O. , Gerasimov G. A. , Artemova A. M. , Tomashevsky D. I. , Gerasimov V. G. , Benker G. 
Published: October 2019

The efficiency of therapy with a combined thyroxin-iodine drug and monotherapy with thyroxin was compared in patients with diffuse nontoxic goiter (DNG), and the effect of iodine intake was evaluated. The study was carried out in an outpatient setting by the double blind method in 46 women aged 18-50 years with DNG: 22 were treated by the combined drug (TI) containing 100 pg L-thyroxin and 100 pg potassium iodide per tablet (lodthyrox, Merck KGaA) and 24 were treated by thyroxin (T) in a dose of 100 pg (Euthyrox, Merck KGaA). The treatment was administeredfor 1 year. A year after this treatment, 15 women were treated with iodinated oil (IO) (lipidol capsules, Guerbet) containing 380 mg iodine. Thyroid volume, concentrations of intrathyroid stable iodine (ISI), pituitary thyrotropic hormone, free triiodothyronin and thyroxin, and antibodies to thyroglobulin and thyroid peroxidase in the blood were evaluated in all women before and during treatment.
Therapy with T and TI equally decreased the size of the thyroid in DNG. ISI concentration decreased during TI treatment less than during monotherapy. Thyroid volume increased to the pre-treatment size 12 months after therapy with T or TI was discontinued, while ISI concentration remained lowered. Administration of IO led to a decrease in the thyroid size, less pronounced than during T or TI treatment, and to an increase in ISI concentration.
Biochar application in alkaline soil and its effect on soil and plant
Authors: SALEM Tamer Mohamed , REFAIE Khaled Mohamed , SHERIF Abd El-Hamid El-Ghadban Abd El-Lateif , EID Mohamed Ahmed Mohamed 
Published: October 2019

Scientists reported that biochar can improve soil properties in acidic soils, while in alkaline soils were shown negative results. A field study was done to evaluate the effect of biochar application solely in alkaline soil compared with biochar composts with farm yard manure (BC-FYM) and sulfur (BC-S). The results revealed that using solely biochar decreased yield of potatoes tubers to more than 6 % and 10 % using mineral and organic fertilization, respectively. This was attributed to the alkalinity effect of biochar and raises the soil pH, which might precipitate macro and micro elements in soil and become unavailable for plant absorption. While using mixtures of BC-FYM and BC-S were shown to enhance yield productivity of potatoes tubers 11.7 % and equal to control under mineral fertilization; and 25.13 % and 10.53 % using organic fertilization, respectively. Mixture of BC-FYM and BC-S proved to have the ability for recovering the alkalinity effect of biochar, improve nutrients availability in soil and increase crop yield of potatoes. In general, mixing biochar with FYM was efficient, economical and environmentally sound solution in alkaline soils.
Water use Efficient Sunflower Hybrids having Diverse Cytoplasmic Background
Authors: Tyagi Vikrant , Dhillon S. K. 
Published: October 2019

Abstract
A set of fifty two hybrids developed through line×tester breeding design were sown in randomized block design with three replications to evaluate their performance for seed yield under two environments (normal irrigation and water stress). Drought resistant indices and multivariate statistical analysis from the pooled data obtained from water stress and normal irrigated environments over the two years. Hybrid PRUN-29A × RCR-8297 (1.55) and 40A × P100R (1.55) had the largest stress tolerance index (STI) rate and hybrid ARG-2A × P69R the smallest rate (a high STI rate for the genotype represents its high drought resistance and its high yielding potential). Hybrid ARG-6A × P69R (2.41) had the largest extent (susceptible) of Stress susceptibility index (SSI), while hybrid E002-91 × RCR-8297 (0.13) had the least (resistant) extent a large extent of this index indicates the genotype susceptibility to drought. In terms of yield stability index (YSI), hybrid 40A × RCR-8297 (0.51) and ARG-6A × P69R (0.51) and hybrid ARG-2A × P69R (1.18) had the smallest and the largest rate respectively (genotypes with high YSI are expected to yield highly in stress conditions. Hybrid 40A × RCR-8297 (30.36) and PRUN-29A × P69R (−10.07) displayed the least and the most amount of tolerance index (TOL) index, a high amount of TOL is a sign of genotype susceptibility to stress. Hybrid PRUN-29A × P69R (1.53) displayed the least extent of yield index (YI), while hybrid ARG-6A × P69R (0.51) and 40A × RCR-8297 (0.51) displayed the highest extent.
Viktor Frankl on all people’s freedom to find their lives meaningful
Authors: Landau Iddo 
Published: October 2019

Abstract
According to Viktor Frankl, although people are not always free to choose the conditions in which they find themselves, they are always free to choose their attitude towards these conditions and, thus, are always free to find their lives meaningful. This basic tenet of Frankl’s theory is also often repeated approvingly in the secondary literature. I argue that the claim is wrong; not all people are free to find their lives meaningful. Counterexamples include people who suffer from severe depression or people who, due to lack of sufficient intelligence, ability to focus, or determination cannot profit from psychological counseling (including logotherapeutic counseling). I also criticize Frankl’s oft-repeated argument that some people’s success in finding their lives meaningful in the concentration camps shows that all people are free to find their lives meaningful. Frankl’s discussion of the noetic dimension and its relation to other dimensions of the human personality is also insufficient for defending his claim about all people’s freedom to find their lives meaningful. Frankl’s theory of the noos suggests that all people’s lives are meaningful. But since not all people’s lives are meaningful, Frankl’s claims about the noos seem incorrect: either some people do not have (or are not also) a noetic dimension or the noetic dimension does not always endow life with meaning. Further, the claim that, thanks to all people’s noetic dimension, all people’s lives are already meaningful is in tension with the claim that all people can wrest meaning from life. I suggest that understanding Frankl as only claiming that all people have a potential for meaningful lives is also unhelpful. Finally, I discuss the implications of my criticism for Frankl’s theory at large. I argue that much in this very helpful theory can be retained, but identify those aspects of the theory that need to be modified.
Absurd relations
Authors: Fox Jacob 
Published: October 2019

Abstract
Absurdist accounts of life’s meaning posit that life is absurd because our pretensions regarding its meaning conflict with the actual or perceived reality of the situation. Relationary accounts posit that contingent things gain their meaning only from their relationship to other meaningful things. I take a detailed look at the two types of account, and, proceeding under the assumption that they are correct, combine them to see what the implications of such a combination might be. I conclude that another way of looking at the absurdity of life is to see it as a conflict between our dual beliefs that there exist intrinsically meaningful contingent things, and that contingent things may only gain their meaning extrinsically through their relationships to other meaningful things. In this way, I provide another lens through which feelings of life’s absurdity may be interpreted and analysed: as the conflict between the simultaneous beliefs in both intrinsically and relationally meaningful contingent things. Looking through this lens gives us an entirely different framework for analysing life’s absurdity than that which Nagel described in 1971, providing opportunity for more potential avenues of analysis and discussion.
Intelligibility without meaning: Nagel, and the cosmos
Authors: Malachowski Alan 
Published: October 2019

Abstract
Cosmic questions concern the relationship between the meaning we attribute to our lives and the cosmos within which such lives are situated. After explaining why such questions are liable to seem problematic, this article considers two responses to the envisaged difficulties. The first, a dismissive philosophical response, is itself dismissed. And, the second, which takes into account the socio-historical context of these difficulties, points towards Richard Rorty’s idea of radical self-reliance as a solution. Thomas Nagel’s exceptionalism, his reluctance to accept either of these responses is then criticized on the grounds that it resurrects a conception of the religious temperament that is no longer tenable.
Beauvoir’s ethics, meaning, and competition
Authors: Popa Elena 
Published: October 2019

Abstract
This paper discusses Simone de Beauvoir’s views on the meaning of life as presented in The Ethics of Ambiguity. I argue that Beauvoir’s view matches contemporary hybrid views on the meaning of life, incorporating both subjective and objective elements, while connecting them in a distinct way—through the tension between self and other. I then analyze the meaning of excessively competitive projects through Beauvoir’s ethics and conclude that success that amounts to denying other people’s access to the things one values is absurd. I use the case of contemporary academia as an illustration of extreme competition, then employ Beauvoir’s views to suggest a shift towards more meaningful practices.
A Meaningful life
Authors: Shand John 
Published: October 2019

Abstract
There can be no such thing as the meaningful life, but only a meaningful life for a particular life as it is lived. Thus, there are meaningful lives, which are lives that make sense and are sufficiently aligned, these two characteristics being honed successively by the limits of a particular contingent form of life, a particular individual of that form of life, and a particular time in the life of that individual. Only the form of a meaningful life may be given, which is sense and alignment, whereas its content may only be determined by the individual whose life it is.
Is the desire for a meaningful life a selfless desire?
Authors: Thomas Joshua Lewis 
Published: October 2019

Abstract
Susan Wolf defines a meaningful life as one that is somewhat successfully engaged in promoting positive value. I grant this claim; however, I disagree with Wolf’s theory about why we desire meaningfulness, so understood. She suggests that the human desire for meaningfulness is derived from an awareness of ourselves as equally insignificant in the universe and a resulting anti-solipsistic concern for promoting goodness outside the boundaries of our own lives. I accept that this may succeed in explaining why people want to engage in projects that happen to be meaningful. Nevertheless, I argue that Wolf fails to explain why people have a desire for meaningfulness itself. In other words, she has told us one reason we may be motivated to promote positive value, but not why we personally want to be the people who promote it—why we think it is a good thing that meaningful acts be done, but not why we want them to be our meaningful acts. In detailing my response, I follow Wolf in relating our desire for meaningfulness to a kind of love-based motivation. However, I argue that it has more in common with a selfish form of love than the altruistic kind of love proposed by Wolf. Finally, I suggest an alternative explanation which I believe can more fully account for our desire for meaningfulness: the prospect of disappearing from the universe without a trace makes us anxious, so we pursue meaningful achievements in an attempt to make our own physical deaths less final.
“Would my life still be meaningful?”: Intersubjectivism and changing meaning in life
Authors: Politi Vincenzo 
Published: October 2019

Abstract
Susan Wolf maintains that the meaningfulness of a life arises when someone acts upon the subjective desire of doing something objectively valuable. This amounts to a hybrid view, which contains both subjectivist and objectivist elements. Wolf’s tentative definition of what is objectively valuable amounts to what, in this article, we define as ‘intersubjectivism’. As it will be argued, however, intersubjectivism poses a number of problems, which are exacerbated in contemporary society and which shed a new light on the problem of meaning in life.
Money and the meaning of life: The fantasy of instant wealth
Authors: Wendling Amy E. 
Published: October 2019

Abstract
Is the meaning of life to get rich quick? That would certainly explain the way many people have lived under the spell of a constitutive fantasy: the fantasy of instant wealth. Drawing on Lacan’s Discourse of the Capitalist, the article explores the fantasy of instant wealth and its relationship to addiction, especially addiction to shopping. The article concludes with a meditation on how the fantasy of instant wealth supplants and in some ways contradicts another fantasy: the fantasy of labour.
Mechanics that triumph over mechanism: Bergson on the meaning of life
Authors: Meechan John 
Published: October 2019

Abstract
In this paper I explore Henri Bergson’s notion of the meaning of life by focusing on two places where he discusses it in his work. The first is Creative Evolution (1907, CE), where a bio-ontological meaning of life is proposed in terms of the ongoing ‘advance’ of the élan vital. Bergson conceives of this vital tendency towards freer activity in terms of nature’s pursuit of a mechanics that would triumph over mechanism. The second is a lesser-known paper called ‘Psycho-physical Parallelism and Positive Metaphysics’ (1901, ‘PPPM’), where Bergson articulates the same themes concerning the evolutionary relationship between life and matter, only this time gives an ethical rendition of the meaning of life. Discerning the true sense of the distinction between mind and body, he claims, will allow us to understand the reason they ‘unite and collaborate’, and thereby to speculate on thought’s apparent trajectory towards an independence from matter. While the latter position appears to be inscribed within the former, this continuity nonetheless resists reducing the ethical to a biological essentialism. This is ensured by the ‘virtual’ nature he ascribes to life’s movement, which shows that the ethical meaning of life is ultimately grounded in an ontology premised upon the irreducibly open and inventive rather than on the reductively closed and repetitive. In turn, this conception of life’s virtuality further illuminates what Bergson might mean, from an ethical perspective, as regards a progressive independence from matter, which I propose in terms of a withdrawal from the body and the present, with a view to a superior moral activity.
Schelling, esotericism and the meaning of life
Authors: Pitkänen Olli Petteri 
Published: October 2019

Abstract
F.W.J. Schelling argues in his middle period work Philosophical Inquiries into the Nature of Human Freedom that will should be understood as the most fundamental constitutive element of reality. Though it is often downplayed in recent scholarship, Schelling derived his most central ideas for this work more or less directly from the theosophy of Jacob Boehme. I will argue that far from peripheral and antiquated curiosity, Schelling´s esoteric influences constitute the very foundation of his middle period thought. Schelling´s affinity to esotericism enabled him to develop a form of pantheism, which is not tied to the familiar problematic aspects of traditional Christian and post-Christian narratives. In mainstream Christianity, the meaning of life is dependent on the almighty God´s will, for which nature is inherently meaningless material. For Schelling, by contrast, nature itself is constitutively willing and meaningful. Consequently, owing to his esoteric influences, Schelling provides an account of the meaning of life which diverges from the dominant idea of Western philosophical and theological tradition that the meaning of life consists in a ”true world” or ”destination” beyond immanent reality.
Variability of Multiangle Isometric Force-Time Characteristics in Trained Men
Authors: Oranchuk Dustin J. , Storey Adam G. , Nelson André R. , Neville Jonathon G. , Cronin John B. 
Published: October 2019

Abstract
Oranchuk, DJ, Storey, AG, Nelson, AR, Neville, JG, and Cronin, JB. Variability of multiangle isometric force-time characteristics in trained men. J Strength Cond Res 36(1): 284–288, 2022—Measurements of isometric force, rate of force development (RFD), and impulse are widely reported. However, little is known about the variability and reliability of these measurements at multiple angles, over repeated testing occasions in a homogenous, resistance-trained population. Thus, understanding the intersession variability of multiangle isometric force-time characteristics provides the purpose of this article. Three sessions of isometric knee extensions at 40°, 70°, and 100° of flexion were performed by 26 subjects across 51 limbs. All assessments were repeated on 3 occasions separated by 5–8 days. Variability was qualified by doubling the typical error of measurement (TEM), with thresholds of 0.2–0.6 (small), 0.6–1.2 (moderate), 1.2–2.0 (large), 2.0–4.0 (very large), and >4.0 (extremely large). In addition, variability was deemed large when the intraclass correlation coefficient (ICC) was <0.67 and coefficient of variation (CV) >10%; moderate when ICC >0.67 or CV <10% (but not both); and small when both ICC >0.67 and CV <10%. Small to moderate between-session variability (ICC = 0.68–0.95, CV = 5.2–18.7%, TEM = 0.24–0.49) was associated with isometric peak force, regardless of angle. Moderate to large variability was seen in early-stage (0–50 ms) RFD and impulse (ICC = 0.60–0.80, CV = 22.4–63.1%, TEM = 0.62–0.74). Impulse and RFD at 0–100 ms, 0–200 ms, and 100–200 ms were moderately variable (ICC = 0.71–0.89, CV = 11.8–42.1%, TEM = 0.38–0.60) at all joint angles. Isometric peak force and late-stage isometric RFD and impulse measurements were found to have low intersession variability regardless of joint angle. However, practitioners need to exercise caution when making inferences about early-stage RFD and impulse measures due to moderate-large variability.