bluuebunny/crossref_metadata_2025_split huggingface dataset:
Participation of pro-inflammatory cytokines in neuropathic pain evoked by chemotherapeutic oxaliplatin via central GABAergic pathway
Authors: Xu Dongsheng , Zhao Hui , Gao Han , Zhao Huiling , Liu Dandan , Li Jing 
Published: June 2018

Background Neuropathic pain is observed in patients as chemotherapeutic oxaliplatin is used to treat metastatic digestive tumors; however, the mechanisms responsible for hyperalgesia are not well understood. Chronic neuroinflammation is one of the hallmarks of pathophysiology of neuropathic pain. Since the midbrain periaqueductal gray is an important component of the descending inhibitory pathway controlling on central pain transmission, we examined the role for pro-inflammatory cytokines system of the periaqueductal gray in regulating mechanical hyperalgesia and cold hypersensitivity evoked by oxaliplatin. Methods Neuropathic pain was induced by intraperitoneal injection of oxaliplatin in rats. ELISA and western blot analysis were used to examine pro-inflammatory cytokine levels and their receptors expression. Results IL-1β, IL-6, and TNF-α were elevated within the periaqueductal gray of oxaliplatin rats. Protein expression of IL-1β, IL-6, and TNF-α receptors (namely, IL-1R, IL-6R, and TNFR subtype TNFR1) in the plasma membrane periaqueductal gray of oxaliplatin rats was upregulated, whereas the total expression of pro-inflammatory cytokine receptors was not altered. In oxaliplatin rats, impaired inhibitory gamma-aminobutyric acid within the periaqueductal gray was accompanied with decreases in withdrawal thresholds to mechanical stimulus and % time spent on the cold plate. Our data further showed that the concentrations of gamma-aminobutyric acid were largely restored by blocking those pro-inflammatory cytokine receptors in periaqueductal gray of oxaliplatin rats; and mechanical hyperalgesia and cold hypersensitivity evoked by oxaliplatin were attenuated. Stimulation of gamma-aminobutyric acid receptors in the periaqueductal gray also blunted neuropathic pain in oxaliplatin rats. Conclusions Our data suggest that the upregulation of pro-inflammatory cytokines and membrane pro-inflammatory cytokine receptor in the periaqueductal gray of oxaliplatin rats is likely to impair the descending inhibitory pathways in regulating pain transmission and thereby contributes to the development of neuropathic pain after application of chemotherapeutic oxaliplatin.
Biomechanical Comparison of Screw Fixation Versus a Cortical Button and Self-tensioning Suture for the Latarjet Procedure
Authors: Provencher Matthew T. , Aman Zachary S. , LaPrade Christopher M. , Bernhardson Andrew S. , Moatshe Gilbert , Storaci Hunter W. , Chahla Jorge , Turnbull Travis Lee , LaPrade Robert F. 
Published: June 2018

Background: Metal screws are traditionally used to fix the coracoid process to the glenoid. Despite stable fixation, metal screws have been associated with hardware complications. Therefore, some studies have advocated for suture button fixation during the Latarjet procedure to reduce the complications associated with screw fixation. Purpose: To biomechanically evaluate the ultimate failure load of a cortical button and self-tensioning suture versus metal screws for coracoid graft fixation during the Latarjet procedure. Study Design: Controlled laboratory study. Methods: Eight matched pairs of fresh-frozen, male cadaveric shoulders (N = 16) underwent the Latarjet procedure. The shoulders of each pair were randomly assigned to 1 of 2 groups: fixation using two 3.75-mm cannulated, fully threaded metal screws or fixation using a double suture button construct. Specimens were secured in a dynamic testing machine and cyclically preconditioned from 2 to 10 N at 0.1 Hz for 10 cycles. After preconditioning, specimens were pulled to failure at a normalized displacement rate of 400% of the measured gauge length per minute. The ultimate failure load and mechanism of failure were recorded for each specimen. Results: The mean ultimate load to failure for screw fixation (226 ± 114 N; 95% CI, 147-305 N) was not significantly different from that for suture button fixation (266 ± 73 N; 95% CI, 216-317 N) ( P = .257). The mean strain at failure for screw fixation (63% ± 21%; 95% CI, 48%-77%) was not significantly different from that for suture button fixation (86% ± 26%; 95% CI, 69%-104%) ( P = .060). The most common mechanism of failure for the screw fixation method was at the bone block drill holes, while an intramuscular rupture at the clamp-muscle interface occurred for the suture button construct. Conclusion: The screw and suture button fixation techniques exhibited comparable biomechanical strength for coracoid bone block fixation of the Latarjet procedure. Clinical Relevance: Metal screws have been reported to be a large contributor to intraoperative and postoperative complications. Therefore, given the results of the current study, a suture button construct may be an alternative to metal screw fixation during the Latarjet procedure. However, further clinical studies are warranted.
Passive Knee Stability After Anterior Cruciate Ligament Reconstruction Using the Endobutton or ToggleLoc With ZipLoop as a Femoral Fixation Device: A Comparison of 1654 Patients From the Danish Knee Ligament Reconstruction Registry
Authors: Asmussen Christian Asmus Peter , Attrup Mikkel Lindegaard , Thorborg Kristian , Hölmich Per 
Published: June 2018

Background: Biomechanical studies show varying results regarding the elongation of adjustable fixation devices. This has led to growing concern over the stability of the ToggleLoc with ZipLoop used in anterior cruciate ligament (ACL) reconstruction (ACLR) in vivo. Purpose/Hypothesis: The purpose of this study was to compare passive knee stability 1 year after ACLR in patients in whom the Endobutton or ToggleLoc with ZipLoop was used for femoral graft fixation. The hypothesis was that the ToggleLoc with ZipLoop would be inferior in knee stability to the Endobutton 1 year after primary ACLR. Study Design: Cohort study; Level of evidence, 2. Methods: Data from 3175 patients (Endobutton: n = 2807; ToggleLoc with ZipLoop: n = 368) were included from the Danish Knee Ligament Reconstruction Registry (DKRR) between June 2010 and September 2013. Data were retrieved from standardized ACL forms filled out by the operating surgeon preoperatively, during surgery, and at a clinical examination 1 year after surgery. Passive knee stability was evaluated using 1 of 2 arthrometers (Rolimeter or KT-1000 arthrometer) and the pivot-shift test. Using the same database, the number of reoperations performed up to 4 years after primary surgery was examined. Results: Full data were available for 1654 patients (Endobutton: n = 1538; ToggleLoc with ZipLoop: n = 116). ACLR with both devices resulted in increased passive knee stability ( P < .001). Patients who received the ToggleLoc with ZipLoop were found to have a better preoperative ( P = .005 ) and postoperative ( P < .001) pivot-shift test result. No statistically significant difference regarding the number of reoperations ( P = .086) or the time to reoperation ( P = .295) was found. Conclusion: Patients who underwent fixation with the ToggleLoc with ZipLoop had improved passive knee stability 1 year after surgery, measured by anterior tibial translation and pivot-shift test results, similar to patients who underwent fixation with the Endobutton. No difference was seen in knee stability or reoperation rates between the 2 devices.
Synthesis of impregnated bentonite using ultrasound waves for application in the Fenton process
Authors: Bečelić-Tomin M. , Kulić A. , Kerkez Đ. , Tomašević Pilipović D. , Pešić V. , Dalmacija B. 
Published: June 2018

ABSTRACTThe use of clays as industrial catalysts requires optimization of modification methods during their preparation. The objective of this paper was to improve the traditional method of bentonite impregnation using ultrasound. For this purpose, three series of samples with Fe3+/clay molar ratios of 0.6–11 mmol/g were prepared, which differed in terms of preparation procedure. The first batch of samples was subjected to the conventional method of impregnation, where total synthesis of catalysts took 4 h. The other two series of samples were prepared with impregnation improved by ultrasound: preparation of Fe-polycation (5 min) and then its incorporation with a clay suspension for 5 and 10 min. The effect of clay preparation method on the catalyst stability and efficiency in a heterogeneous Fenton process was studied on aqueous solutions of synthetic Reactive Blue 4 dye. The catalysts prepared by the conventional method and the improved ultrasound method achieved high efficacy (91–97%, respectively), but their stability was different in the Fenton process. The catalysts prepared using ultrasound for 10 min exhibited greatest stability in the Fenton process. The catalysts synthesized with different Fe loadings displayed an increase in specific surface area and mesoporosity. Samples prepared by the improved impregnation method are comparable in terms of their characteristics with their counterparts prepared by the conventional method. It is thus possible to reduce the time taken by traditional catalyst synthesis by using optimized exposure time to ultrasonic waves.
Ammonium-bearing micas in very low-grade metapelites: micro- and nano-texture and composition
Authors: Bauluz Blanca , Nieto Fernando 
Published: June 2018

ABSTRACTThe present study examines the micro- and nano-texture and composition of ammonium-bearing and potassium micas in very-low grade metamorphic black Silurian shales from the SE Iberian Range (NE Spain). Two organic-rich shales were studied by X-ray diffraction (XRD), infrared spectroscopy (IR), transmission electron microscopy (TEM), analytical electron microscopy (AEM) and electron energy loss spectroscopy (EELS). The XRD showed the presence of two populations of micas: pure K micas with d001 = 9.98 Å and ammonium-bearing micas with larger d001 values (10.08 Å and 10.05 Å). The latter values indicate NH4 contents between 13 and 29% in the interlayer, which was confirmed by IR. Interstratifications of smectite and mica layers in the mica packets were not detected by XRD and TEM. Mica packets with sizes ranging from 100 to 250 Å show disordered polytypes and (001) lattice fringes that reflect the presence of K- and NH4-bearing layers (9.9–10.2 Å).The combination of AEM and EELS analyses on powdered and lamellar samples indicates that micas have typical dioctahedral compositions with highly variable K contents. This variation in K is consistent with the presence of K and NH4 in the interlayers, even though the NH4 and K are not distributed homogeneously; rather they are segregated in nm-sized domains in the mica interlayer.
Reference equations for pulmonary diffusing capacity of carbon monoxide and nitric oxide in adult Caucasians
Authors: Munkholm Mathias , Marott Jacob Louis , Bjerre-Kristensen Lars , Madsen Flemming , Pedersen Ole Find , Lange Peter , Nordestgaard Børge G. , Mortensen Jann 
Published: June 2018

The aim of this study was to determine reference equations for the combined measurement of diffusing capacity of the lung for carbon monoxide (CO) and nitric oxide (NO) (DLCONO). In addition, we wanted to appeal for consensus regarding methodology of the measurement including calculation of diffusing capacity of the alveolo-capillary membrane (Dm) and pulmonary capillary volume (Vc).DLCONOwas measured in 282 healthy individuals aged 18–97 years using the single-breath technique and a breath-hold time of 5 s (true apnoea period). The following values were used: 1) specific conductance of nitric oxide (θNO)=4.5 mLNO·mLblood−1·min−1·mmHg−1; 2) ratio of diffusing capacity of the membrane for NO and CO (DmNO/DmCO)=1.97; and 3) 1/red cell CO conductance (1/θCO)=(1.30+0.0041·mean capillary oxygen pressure)·(14.6/Hb concentration in g·dL−1).Reference equations were established for the outcomes ofDLCONO, includingDLCOandDLNOand the calculated valuesDmandVc. Independent variables were age, sex, height and age squared.By providing new reference equations and by appealing for consensus regarding the methodology, we hope to provide a basis for future studies and clinical use of this novel and interesting method.
Implementation of Perioperative Music Using the Consolidated Framework for Implementation Research
Authors: Carter Jessica E. , Pyati Srinivas , Kanach Frances A. , Maxwell Ann Miller W. , Belden Charles M. , Shea Christopher M. , Van de Ven Thomas , Thompson Jillian , Hoenig Helen , Raghunathan Karthik 
Published: June 2018

BACKGROUND:
Complementary integrative health therapies have a perioperative role in the reduction of pain, analgesic use, and anxiety, and increasing patient satisfaction. However, long implementation lags have been quantified. The Consolidated Framework for Implementation Research (CFIR) can help mitigate this translational problem.

METHODS:
We reviewed evidence for several nonpharmacological treatments (CFIR domain: characteristics of interventions) and studied external context and organizational readiness for change by surveying providers at 11 Veterans Affairs (VA) hospitals (domains: outer and inner settings). We asked patients about their willingness to receive music and studied the association between this and known risk factors for opioid use (domain: characteristics of individuals). We implemented a protocol for the perioperative use of digital music players loaded with veteran-preferred playlists and evaluated its penetration in a subgroup of patients undergoing joint replacements over a 6-month period (domain: process of implementation). We then extracted data on postoperative recovery time and other outcomes, comparing them with historic and contemporary cohorts.

RESULTS:
Evidence varied from strong and direct for perioperative music and acupuncture, to modest or weak and indirect for mindfulness, yoga, and tai chi, respectively. Readiness for change surveys completed by 97 perioperative providers showed overall positive scores (mean >0 on a scale from −2 to +2, equivalent to >2.5 on the 5-point Likert scale). Readiness was higher at Durham (+0.47) versus most other VA hospitals (range +0.05 to +0.63). Of 3307 veterans asked about willingness to receive music, approximately 68% (n = 2252) answered “yes.” In multivariable analyses, a positive response (acceptability) was independently predicted by younger age and higher mean preoperative pain scores (>4 out of 10 over 90 days before admission), factors associated with opioid overuse. Penetration was modest in the targeted subset (39 received music out of a possible 81 recipients), potentially reduced by device nonavailability due to diffusion into nontargeted populations. Postoperative recovery time was not changed, suggesting smooth integration into workflow.

CONCLUSIONS:
CFIR-guided implementation of perioperative music was feasible at a tertiary VA hospital, with moderate penetration in a high-risk subset of patients. Use of digital music players with preferred playlists was supported by strong evidence, tension for change, modest readiness among providers, good acceptability among patients (especially those at risk for opioid overuse), and a protocolized approach. Further study is needed to identify similar frameworks for effective knowledge-translation activities.
Liver- and Colon-Specific DNA Methylation Markers in Plasma for Investigation of Colorectal Cancers with or without Liver Metastases
Authors: Gai Wanxia , Ji Lu , Lam W K Jacky , Sun Kun , Jiang Peiyong , Chan Anthony W H , Wong John , Lai Paul B S , Ng Simon S M , Ma Brigette B Y , Wong Grace L H , Wong Vincent W S , Chan Henry L Y , Chiu Rossa W K , Lo Y M Dennis , Chan K C Allen 
Published: June 2018

Abstract

BACKGROUND
Measurement of DNA derived from different tissues in the circulating DNA pool can provide important information regarding the presence of many pathological conditions. However, existing methods involving genome-wide bisulfite sequencing are relatively expensive and may present challenges for large-scale analysis.

METHODS
Through identifying differentially methylated regions in the liver and colon compared with other tissues, we identified 2 markers and developed corresponding droplet digital PCR assays. Plasma concentrations of liver-derived and colon-derived DNA were measured for 13 liver transplant recipients, 40 liver cancer patients, and 62 colorectal cancer (CRC) patients (27 with and 35 without liver metastases).

RESULTS
In liver transplant recipients, the fractional concentration of liver-derived DNA measured using the liver-specific methylation marker and donor-specific alleles showed good correlation (Pearson R = 0.99). In liver cancer patients, the concentration of liver-derived DNA correlated positively with the maximal dimension of the tumor (Spearman R = 0.74). In CRC patients with and without liver metastasis, the plasma concentrations of colon-derived DNA (median, 138 copies/mL and 4 copies/mL, respectively) were increased compared with the 30 healthy controls (26 had undetectable concentrations). The absolute concentration of liver-derived DNA provided a better differentiation between CRC patients with and without liver metastasis compared with the fractional concentration (area under ROC curve, 0.85 vs 0.75).

CONCLUSIONS
Quantitative analysis of plasma DNA with tissue-specific methylation patterns using droplet digital PCR is applicable for the investigation of cancers and assessing organ transplantation. This approach is useful for differentiating patients with and without metastases to other organs.
Book Reviews
Authors: Watts Jonathan P. , Cappuccitti Jessica , DiRisio Michael 
Published: June 2018

Abstract
EXHIBITION, DESIGN, PARTICIPATION: ‘AN EXHIBIT’ 1957 AND RELATED PROJECTS, ELENA CRIPPA AND OTHERS London: Afterall Books (2016), 240 pp., Paperback, ISBN: 978-3-863-35897-6, £14.95
PUBLIC SERVANTS: ART AND THE CRISIS OF THE COMMON GOOD, JOHANNA BURTON, SHANNON JACKSON AND DOMINIC WILLSDON (EDS) Cambridge, MA and London: MIT Press (2016), 518 pp., Hardcover, ISBN: 978-0-262-03481-4, US $44.95
TROUBLER LA FÊTE, RALLUMER NOTRE JOIE/TO SPOIL THE PARTY, TO SET OUR JOY ABLAZE Montreal: Journée sans culture (2016) 142 pp., Paperback, ISBN: 978-2-98163-06, CDN $30.00
SURVEY FOR CULTURAL WORKERS/QUESTIONNAIRE POUR TRAVAILLEURS CULTURELS, JO-ANNE BALCAEN (ED.) Montreal: self-published (2015) 76 pp., Paperback, ISBN: 978-0-994-72830-2, CDN $20.00
Disobedient Objects: Towards a Museum Insurgency
Authors: Lyons Steve 
Published: June 2018

Abstract
Assembling a wide range of protest objects produced since the late 1970s, Disobedient Objects at the Victoria and Albert Museum, London (2014–15) aimed to present the expansive material culture of social movements from a global perspective while charting a ‘people’s history of art and design from below’. This article examines the critical intentions behind the exhibition, compares it to other recent large-scale exhibitions on activist art and situates it within a broader field of museum activism, demonstrating how it displayed not only a collection of disobedient objects but also a model for disobedient curating by directing institutional resources towards ongoing movements and campaigns.
‘The Museum of Today’: Harald Szeemann’s Science Fiction
Authors: Muller Lizzie 
Published: June 2018

Abstract
Harald Szeemann’s 1967 exhibition Science Fiction is ripe for re-examination. Insights gained from unpublished handwritten notes reveal Szeemann’s endless listmaking as a connective curatorial methodology that sought to re-create an expansive science fiction ‘state of mind’. The resulting exhibition of over 3,000 diverse objects stands in contrast to the sterile space-age aesthetics of the white cube that was, at the same moment, becoming the pre-eminent form of contemporary art display. The popular response to Science Fiction stimulated Szeemann to conceptualize a ‘Museum of Today’ that would dynamically reflect its moment in time – a concept that resonates in Szeemann’s subsequent work and in contemporary curatorial practice.
Industrial transformation in Chinese animation cinema (1995–2015)
Authors: Chen Shaopeng 
Published: June 2018

Abstract
This article focuses on Chinese cinema animation works between 1995 and 2015 in terms of industrial transformation, thus providing an up-to-date view of cinema animation as an important subsector of Chinese cultural creative industries. The findings of this study can be divided into three parts. First, Chinese cinema animation shows a child-oriented trend over the last two decades. That is to say, Chinese animators always, consciously or unconsciously, find opportunities to cater to children’s pleasure while ignoring the entertainment appeal for other age groups. Second, the serialized and broad-based cinema animations, which have the possible advantage of the audience’s pre-existing familiarity with the characters and stories, can be regarded as an important link of animation value chain. Meanwhile, the above works have exerted mixed effects on its parent brand. Finally, the majority of completely original animated films in China have fallen into a paradox between sound reputation and poor box office performance.
Fandry and Sairat: Marginal narratives and subjectivities in the new Marathi cinema
Authors: Ingle Hrishikesh 
Published: June 2018

Abstract
New Marathi cinema has witnessed a remarkable moment recently when Sairat (The Wild, Manjule, 2016) broke box-office records, with collections touching the 100 Cr. (INR, one Billion). Sairat and Fandry (Pig, Manjule, 2014) are films that present narratives cantered on caste marginalization in rural Maharashtra. In depicting the realities of marginal existence Manjule has mobilized the industrial tendencies of mainstream filmmaking, thus opening up the films for a wider public circulation, and the consequent social discourses arising from it. The route to this, however, is through the evocative portrayal of marginal subjectivities that has largely remained stereotypical in the history of Marathi cinema. This article argues that marginal narratives and subjectivity in Sairat and Fandry are a reification of serious themes that, in the context of multiplex-centric, neo-liberal film culture, seem to posit moments of resistance. The article deliberates with two questions that the films have thrown up: first is the notion of marginal subjectivities. The subjective experience of being socially marginal, which gets highlighted through the story of the lead characters, is of significance here. The narrative articulation of the marginal experience is identified by reading of certain poignant moments in the films. Second, the extratextual, public discourses and events after the films were released are situated to highlight how Fandry and Sairat emerge from a certain social entanglement, and are in turn instrumental in affirming their own commoditized versions. The interviews of the director, various reality-TV events and some indicative discourses on the social media are discussed to consider how the cinema becomes relevant as the site for a critique of the Marathi social realm.
Review
Authors: Pheasant-Kelly Frances 
Published: June 2018

Abstract
Parallel Lines: Post-9/11 American Cinema, Guy Westwell (2014) and The ‘War on Terror’ and American Film: 9/11 Frames Per Second, Terence McSweeney (2014) London: Wallflower Press, 208pp., ISBN: 9780231172035, p/bk, £22.00 Edinburgh: Edinburgh University Press, 242pp., ISBN: 9780748693092, h/bk, £70