bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of laparoscopic holmium laser lithotripsy in the treatment of complicated biliary calculus
Authors: Jin Penghui , Jing Wutang , Zhan Weipeng , Han Caiwen , Si Moubo , Yang Jia , Li Yiping , Gu Yuanhui , Ma Yuntao , Guo Tiankang 
Published: January 2019

Abstract

Backgroud:
The aim of this study was to assess the efficacy and safety of laparoscopic holmium laser lithotripsy (LHLL) in the treatment of complicated biliary calculus.

Methods:
We systematically searched the electronic database (PubMed, EMBASE, Cochrane library, Web of science, and Chinese Biomedical Literature Database) up to May 2018 to identify case-controlled studies that compared LHLL with laparoscopic bile duct exploration (LBDE) for complicated biliary calculus.

Results:
Five case-controlled studies were included, with 541 patients (273 in the LHLL group and 268 in the LBDE group). Compared with LBDE, LHLL was associated with shorter operative time (weighted mean difference [WMD] = -40.04, P < .001) and lower estimated blood loss (EBL) (WMD = -56.42, P < .001), lesser duration of hospitalization (WMD = -3.93, P < .001) and lower rate of residual stone (OR = 0.13, P < .001). There was no statistically significant differences in bile leakage (OR = 0.48, P = .23) and hemobilia (OR = 0.49, 0.41).

Conclusion:
Current evidence suggests that the efficacy of LHLL is superior to that of LBDE but they are similarly safe for the treatment of complicated biliary calculus. Limited by the quantity and quality of the studies included, these conclusions need to be verified by more high-quality studies.
Nurses’ Perspectives of Person-Centered Spinal Cord Injury Rehabilitation in a Digital Hospital
Authors: Burridge Letitia Helen , Foster Michele , Jones Rachel , Geraghty Timothy , Atresh Sridhar 
Published: January 2019

Abstract

Purpose
Nurses’ perspectives on electronic medical record (eMR) use and compatibility with person-centered care (PCC) in rehabilitation were explored.

Design
This cross-sectional, qualitative study involved nurses practicing in a spinal cord injury service within the first Australian tertiary hospital to implement a large-scale eMR system.

Methods
Ten focus groups were audio-recorded and transcribed for thematic analysis.

Findings
The three themes were (1) discovering how eMR fits in a specialty setting, (2) making eMR work through adaptability, and (3) realizing the impact of eMR inclusion in the nurse–patient relationship.

Conclusions
The eMR introduction triggered compensatory practices to manage the complexities and shortcomings of electronic documentation. Nurses adapted routines and reoriented workflows to preserve PCC.

Clinical Relevance
While absorbing eMR-driven changes in documentation, rehabilitation nurses must in parallel manage evolving nursing practice norms in the digital environment in order to sustain PCC. This requires strategic foresight and commitment.
Hospital Length of Stay Reduction Over Time and Patient Readmission for Severe Adverse Events Following Surgery
Authors: Pascal Léa , Polazzi Stéphanie , Piriou Vincent , Cotte Eddy , Wegrzyn Julien , Carty Matthew J. , Chollet François , Sanchez Stéphane , Lifante Jean-Christophe , Duclos Antoine 
Published: January 2019

Objective:
The aim of the study was to investigate whether patients who undergo surgery in hospitals experiencing significant length of stay (LOS) reductions over time are exposed to a higher risk of severe adverse events in the postoperative period.

Summary Background Data:
Surgical care innovation has encouraged hospitals to shorten LOS under financial pressures with uncertain impact on patient outcomes.

Methods:
We selected all patients who underwent elective colectomy or urgent hip fracture repair in French hospitals between 2013 and 2016. For each procedure, hospitals were categorized into 3 groups according to variations in their median LOS as follows: major decrease, moderate decrease, and no decrease. These groups were matched using propensity scores based on patients’ and hospitals’ potential confounders. Potentially avoidable readmission for severe adverse events and death at 6 months were compared between groups using Cox regressions.

Results:
We considered 98,713 patients in 540 hospitals for colectomy and 206,812 patients in 414 hospitals for hip fracture repair before matching. After colectomy, patient outcomes were not negatively impacted when hospitals reduced their LOS [hazard ratio (95% confidence interval): 0.93 (0.78–1.10)]. After hip fracture repair, patients in hospitals with major decreases in LOS had a higher risk of severe adverse events [1.22 (1.11–1.34)] and death [1.17 (1.04–1.32)].

Conclusions:
Patients who underwent surgical procedures in hospitals experiencing major decreases in LOS were demonstrated worse postoperative outcomes after urgent hip fracture repair and not after elective colectomy. Development of care bundles to enhance recovery after emergency surgeries may allow better control of LOS reduction and patient outcomes.
Reporting National Outcomes After Esophagectomy and Gastrectomy According to the Esophageal Complications Consensus Group (ECCG)
Authors: van der Werf Leonie R. , Busweiler Linde A. D. , van Sandick Johanna W. , van Berge Henegouwen Mark I. , Wijnhoven Bas P. L. 
Published: January 2019

Objective:
This nation-wide population-based study aimed to report postoperative morbidity and mortality after esophagectomy and gastrectomy in the Netherlands according to the definitions of the Esophagectomy Complications Consensus Group (ECCG).

Background:
To standardize international outcome reporting in esophageal surgery, the ECCG developed a standardized outcomes set.

Methods:
For this national cohort study, all patients undergoing esophagectomy or gastrectomy for cancer between 2016 and 2017 were selected from the Dutch Upper gastrointestinal Cancer Audit. In a random sample of hospitals, data completeness and accuracy were validated by reabstraction of the data. The investigated outcomes in the present study were postoperative complications, major complications (Clavien–Dindo grade ≥III), and 30-day mortality, according to definitions of the ECCG.

Results:
A total of 2545 patients from 22 hospitals were included. The completeness of the Dutch Upper gastrointestinal Cancer Audit was estimated at 99.8%. Data accuracy on different items was 94% to 100%. After esophagectomy, 1046 of 1617 patients (65%) had a postoperative complication including 468 patients (29%) with a major complication. Most common complications were pneumonia (21%), esophago-enteric leak from anastomosis, staple line or localized conduit necrosis (19%), and atrial dysrhythmia (15%). The 30-day mortality was 1.7%. After gastrectomy, 397 of 928 patients (42%) had a postoperative complication including 180 patients (19%) with a major complication. Most common complications were pneumonia (12%), esophago-enteric leak from anastomosis, staple line or localized conduit necrosis (9%), and acute delirium (5%). The 30-day mortality was 4.4%.

Conclusions:
Reporting complications according to the ECCG platform is feasible in the Netherlands and facilitates international benchmarking.
The Impact of Benson's Relaxation Technique on the Quality of Sleep in the Elderly
Authors: Habibollahpour Mitra , Ranjkesh Fatemeh , Motalebi Seyedeh Ameneh , Mohammadi Fatemeh 
Published: January 2019

Objective:
This study examined the effect of Benson's relaxation technique in the quality of sleep of the elderly.

Method:
The study employed a randomized clinical trial design. A total of 75 elderly suffering from sleep disorder were randomly assigned to either the intervention (n = 38) or control (n = 37) group. The intervention group received Benson's relaxation technique twice a day for 20 minutes through 4 weeks. Petersburg Sleep Quality Index was used to collect the data. Independent and paired t tests were employed to analyze the data.

Findings:
The results of the paired t tests showed significant improvements in intervention group on quality of sleep and its 5 subscales including subjective sleep quality, sleep latency, sleep duration, and sleep efficiency, and the daytime dysfunction improved significantly (P < .000). In addition, independent t tests showed significant differences between the intervention and control groups in the quality of sleep and its 4 subscales including the subjective sleep quality, sleep latency, sleep duration, and habitual sleep efficiency after implementation of intervention (P < .000).

Conclusion:
The results of the present study may support the efficacy of this simple, available, and cost-effective technique on the quality of sleep of elderly people.
Primary Progressive Aphasia
Authors: Ferrari Camilla , Polito Cristina , Vannucchi Sara , Piaceri Irene , Bagnoli Silvia , Lombardi Gemma , Lucidi Giulia , Berti Valentina , Nacmias Benedetta , Sorbi Sandro 
Published: January 2019

Background/Aims:
Few longitudinal studies have explored the progression of cognitive and functional impairment of patients with primary progressive aphasia (PPA). The aims of the study were to describe the clinical, neuroimaging, and genetic features of a cohort of 68 PPA patients, and to outline the natural history of the disease.

Materials and Methods:
A sample of 23 patients with the logopenic variant, 26 with the nonfluent/agrammatic variant, and 19 with the semantic variant was retrospectively collected and followed-up for a maximum of 6 years. Clinical-neuropsychological assessment, fluorodeoxyglucose positron emission tomographic imaging, and genetic analyses were acquired at baseline. Disease progression was evaluated in terms of language impairment, global cognitive decline, and functional dependency.

Results:
During follow-up, one third of subjects presented total language loss, and 20% severe functional dependency. Global cognitive decline after the first year (hazard ratio, 5.93; confidence interval, 1.63-21.56) and high schooling (hazard ratio, 0.07; confidence interval, 0.008-0.74) represented risk factors for functional impairment. The apolipoprotein E status was associated with the progression of cognitive decline. Positive family history for dementia was frequent and 3 genetic autosomal dominant mutations were identified.

Conclusions:
There were no differences in the progression of PPA subtypes. Genetics plays an important role in disease onset and progression.
Ionic strength and calcium regulate the membrane interactions of myelin basic protein and the cytoplasmic domain of myelin protein zero
Authors: Raasakka Arne , Jones Nykola C. , Hoffmann Søren Vrønning , Kursula Petri 
Published: January 2019

AbstractThe formation of a mature myelin sheath in the vertebrate nervous system requires specific protein-membrane interactions. Several myelin-specific proteins are involved in the stacking of lipid membranes into multilayered structures around neuronal axons, and misregulation of these processes may contribute to chronic demyelinating diseases. Two key proteins functioning in myelin membrane binding and stacking are the myelin basic protein (MBP) and protein zero (P0). Other factors, including Ca2+, are important for the regulation of myelination. Here, we studied the effects of ionic strength and Ca2+on the direct molecular membrane interactions of MBP and the cytoplasmic domain of P0 (P0ct). While both MBP and P0ct bound and aggregated negatively charged lipid vesicles, while simultaneously folding, both ionic strength and calcium had systematic effects on these interactions. Especially when decreasing membrane net negative charge, the level and kinetics of vesicle aggregation, which is a functional assay for myelin membrane-stacking proteins, were affected by both salt and Ca2+. The results indicate that the effects on lipid membrane surfaces by ions can directly affect myelin protein-membrane interactions at the molecular level, in addition to signalling effects in myelinating glia.
High functional diversity among Nitrospira populations that dominate rotating biological contactor microbial communities in a municipal wastewater treatment plant
Authors: Spasov Emilie , Tsuji Jackson M. , Hug Laura A. , Doxey Andrew C. , Sauder Laura A. , Parker Wayne J. , Neufeld Josh D. 
Published: January 2019

AbstractNitrification, the oxidation of ammonia to nitrate via nitrite, is an important process in municipal wastewater treatment plants (WWTPs). Members of the Nitrospira genus that contribute to complete ammonia oxidation (comammox) have only recently been discovered and their relevance to engineered water treatment systems is poorly understood. This study investigated distributions of Nitrospira, ammonia-oxidizing archaea (AOA), and ammonia-oxidizing bacteria (AOB) in biofilm samples collected from tertiary rotating biological contactors (RBCs) of a municipal WWTP in Guelph, Ontario, Canada. Using quantitative PCR (qPCR), 16S rRNA gene sequencing, and metagenomics, our results demonstrate that Nitrospira species strongly dominate RBC biofilm samples and that comammox Nitrospira outnumber all other nitrifiers. Genome bins recovered from assembled metagenomes reveal multiple populations of comammox Nitrospira with distinct spatial and temporal distributions, including several taxa that are distinct from previously characterized Nitrospira members. Diverse functional profiles imply a high level of niche heterogeneity among comammox Nitrospira, in contrast to the sole detected AOA representative that was previously cultivated and characterized from the same RBC biofilm. Our metagenome bins also reveal two cyanase-encoding populations of comammox Nitrospira, suggesting an ability to degrade cyanate, which has not been shown previously for Nitrospira that are not strict nitrite oxidizers. This study demonstrates the importance of RBCs as model systems for continued investigation of environmental factors that control the distributions and activities of AOB, AOA, comammox Nitrospira, and other nitrite oxidizers.
Locating suspicious lethal genes by abnormal distributions of SNP patterns
Authors: Ding Xiaojun 
Published: January 2019

AbstractA gene, a locatable region of genomic sequence, is the basic functional unit of heredity. Differences in genes lead to the various congenital physical conditions of people. One kind of these major differences are caused by genetic variations named single nucleotide polymorphisms(SNPs). SNPs may affect splice sites, protein structures and so on, and then cause gene abnormities. Some abnormities will lead to fatal diseases. People with these diseases have a small probability of having children. Thus the distributions of SNP patterns on these sites will be different with distributions on other sites. Based on this idea, we present a novel statistical method to detect the abnormal distributions of SNP patterns and then to locate the suspicious lethal genes. We did the test on HapMap data and found 74 suspicious SNPs. Among them, 10 SNPs can map reviewed genes in NCBI database. 5 genes out of them relate to fatal children diseases or embryonic development, 1 gene can cause spermatogenic failure, the other 4 genes are also associated with many genetic diseases. The results validate our idea. The method is very simple and is guaranteed by a statistical test. It is a cheap way to discover the suspicious pathogenic genes and the mutation site. The mined genes deserve further study.Author summaryXiaojun Ding received the BS, MS and PhD degrees in computer science from Central South University. Now he is a assistant professor in Yulin Normal University. His research interests include computational biology and machine learning.
Embodying circularity through usable relocatable modular buildings
Authors: Kyrö Riikka , Jylhä Tuuli , Peltokorpi Antti 
Published: January 2019

PurposeGlobal megatrends such as urbanization and ageing of the population result in fast-paced demographic changes, which pose different types of challenges for different regions. While many rural municipalities bear the burden of under-used buildings, cities are in a hurry to develop new ones to meet new space demands. The purpose of this paper is to assess the potential of relocatable modular buildings to address these challenges, following the principles of circular economy, while at the same time offering usability.Design/methodology/approachThis multiple case study explores existing relocatable modular health-care buildings in Finland. The case buildings host hospital support functions, imaging services, a health-care centre and a care home. The primary data comprise 21 semi-structured interviews and observation during factory and site visits.FindingsBased on the findings, relocatable modular buildings have many benefits and provide a viable option for cities and municipalities struggling to meet their fluctuating space demands. Some challenges were also identified, mainly derived from the dimensional restrictions of the modules.Originality/valueThis research contributes to the emerging body of knowledge on circular economy in the built environment. More specifically, the research provides a very concrete example of circularity and details a framework for usable and relocatable modular buildings. In conclusion, relocatable modular buildings could solve the challenges posed by quickly changing demographics in different types of regions and deliver both usability and circularity.
Decoding behavioural responses of green hotel guests
Authors: Olya Hossein G.T. , Bagheri Pourya , Tümer Mustafa 
Published: January 2019

Purpose
This study aims to present a unique perspective on the application of the theory of planned behaviour (TPB) in the context of the green lodging industry via configurational modelling of three TPB dimensions in formulating hotel visitors’ behavioural responses. Attitude towards behaviour, subjective norms and perceived behavioural control are the three indicators of TPB used to predict guests’ continued intention to use and recommend green hotels on Cyprus, a Mediterranean island with a fragile ecological system.

Design/methodology/approach
A questionnaire-based survey is used to evaluate the study’s objectives. A total of 320 guests of green hotels were approached between June and July 2017 and invited to participate. Among them, 260 valid cases were obtained and used for data analysis. The structural model was tested using structural equation modelling (SEM), the configurational model was assessed using the fuzzy-set qualitative comparative analysis (fsQCA) and the necessary predictor was evaluated using the necessary condition analysis (NCA).

Findings
The SEM results revealed that attitudes regarding behaviour increased the continued intention to visit and recommend green hotels. Similarly, subjective norms enhanced the guests’ desired behavioural responses. Perceived behavioural control boosted their continued intention to visit, but this was insufficient for predicting green hotel guests’ intention to recommend. The fsQCA results indicated that two causal models explained the conditions of both high and low levels of behavioural responses. The NCA results showed that attitude towards behaviour was the only necessary condition of the two expected behavioural responses.

Originality/value
Several previous studies have tried to modify, decompose or merge the TPB to provide theoretical support for proposed conceptual models indicating visitors’ behaviours. Beyond such attempts, pragmatic analytical approaches (e.g. set-theoretic method) should be applied to present a comprehensive perspective on the association of TPB indicators in decoding the complexity of customers’ behaviours. To the best of the authors’ knowledge, this study is among the first in hospitality research to use three TPB indicators and three analytical approaches to extend the knowledge of guests’ behaviours related to green hotels.
Against all odds: refugees bricoleuring in the void
Authors: Heilbrunn Sibylle 
Published: January 2019

Purpose
In an extreme and intentional institutional void, African refugees in Israel are bricoleuring by building an entrepreneurship market next to an “open” detention camp. The purpose of this paper is to analyze how refugee entrepreneurs overcome institutional voids through bricolage in an illegal marketplace outside the detention camp.

Design/methodology/approach
In order to deal with the question of why and how people act entrepreneurial under extreme circumstances, the interpretive/social constructionist paradigm is applied in form of the multiple stories milieu case study pattern. Data were gathered via official reports, interviews and observations.

Findings
Outside the detention camp it is via bricolage that entrepreneurs address the economic detour in the intentional institutional void. At a place which is meant to make asylum seekers leave Israel by coining them “infiltrators” and by “making their lives miserable,” bricoleurs attend their own and the needs of fellow detainees providing goods and service and community space.

Originality/value
By contextualizing entrepreneurial practices, the paper contributes to the understanding of refugee entrepreneurship by demonstrating how refugees – within the pressure and constraints of context – initiate entrepreneurial activities. Theoretically the paper extends knowledge of minority entrepreneurs who are acting as bricoleurs, explaining how their entrepreneuring can be a kind of space creation process.