bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of frequency of CF care in the US Cystic Fibrosis Foundation Patient Registry
Authors: Hinton Alexandra C. , Sears Edmund H. , Zuckerman Jonathan B. , Lopez-Pintado Sara 
Published: December 2024

Introduction
Prolonged gaps in care of >12-months are frequent among people with cystic fibrosis (pwCF) and are associated with reduced lung function. Comprehensive analysis of patient-level predictors of visit frequency is needed to optimize protocols for stable pwCF and identify subgroups at high risk of gaps and poor outcomes, promoting equitable treatment for all pwCF.

Objective
To determine sociodemographic and disease-related factors predictive of visit frequency in pwCF and to assess how these effects vary across the lifespan.

Methods
We conducted an observational cohort study using data from 2004–2016 for pwCF aged 6–60 years in the US Cystic Fibrosis Foundation Patient Registry. We modeled the relationship between patient-level characteristics and between-visit interval (BVI) using multivariable longitudinal semiparametric regression. BVI was defined as the number of days from the index encounter to the previously recorded visit.

Results
The study included 28,588 pwCF with 859,568 encounters. Overall, 55% of visits occurred within 90 days of the prior visit, adhering to national guidelines. On average, adults without common CF-complications attended clinic approximately every 4 months, with a BVI ≥ 110 days from age 23–56. Males attended clinic less frequently than females (9.8% longer BVI; 95% CI 9.1%, 10.5%; p<0.001), as did non-white individuals (3.6% longer BVI than whites; 95% CI 2.2%, 5.0%; p<0.001), with the greatest differences seen in young adults. Those with public and private insurance largely adhered to current guidelines (maximum average BVI of 90 and 95 days, respectively). In contrast, uninsured individuals over age 25 had a mean BVI ≥ 30 days longer than the insured.

Conclusions
Frequent visits in those with CF-complications likely reflects higher need, while less frequent visits in male, non-white, and uninsured individuals may reflect patient-preference or structural barriers to care. Risk factors for gaps in care should inform changes to CF care recommendations going forward.
Predictors of maternal HIV acquisition during pregnancy and lactation in sub-Saharan Africa: A systematic review and narrative synthesis
Authors: Graybill Lauren A. , Chi Benjamin H. , Hamoonga Twaambo E. , Kasaro Margaret , Hodges Jasmine N. , Richardson Brian D. , Bissram Jennifer S. , Saidi Friday , Mollan Katie R. , Freeborn Kellie , Rosenberg Nora E. , Powers Kimberly A. , Mutale Wilbroad 
Published: December 2024

Objectives
To eliminate vertical transmission of HIV, global institutions recommend using a risk-guided approach for HIV prevention services in antenatal and postnatal settings. Identifying predictors of maternal HIV acquisition can inform the development of risk-guided approaches, but individual studies of predictors can have limited power and generalizability.

Methods
We conducted a systematic review and narrative synthesis to identify common predictors of maternal HIV acquisition in sub-Saharan Africa (SSA). We searched four databases for full-text articles that estimated associations between at least one predictor and risk of HIV acquisition among pregnant and/or lactating women (PLW) in SSA. We restricted our synthesis to predictors assessed in at least four study populations. For these predictors, we summarized how each predictor was defined and used vote counting and descriptive statistics to characterize overall trends.

Results
We identified 26 eligible publications that summarized results from 24 unique studies. Studies were implemented in 12 countries between 1988 and 2021 and enrolled a total of 164,480 PLW at risk of acquiring HIV. Of the 66 predictors evaluated, 16 met our inclusion criteria. Estimated associations tended to be imprecise and variability in how predictors were measured precluded meta-analyses. We observed trends towards a higher risk of maternal HIV acquisition among young women and women who reported early coital debut, multiple partnerships, sexually transmitted infections, being unaware of partner HIV status, or having a partner living with HIV. In most studies, PLW in stable, monogamous relationships experienced a lower risk of acquiring HIV than those who were single, separated, or in a polygynous marriage. HIV risk perception, condom use, and vaginal drying were also commonly associated with HIV acquisition risk.

Conclusions
In our systematic review and narrative synthesis, we identified several easily measured characteristics that were associated with HIV acquisition among PLW in multiple study populations across SSA. Such findings can support the development and refinement of risk-guided approaches for HIV prevention in the region.
Controle do território paraguaio: um novo regime sob a égide da narrativa da mudança do clima?
Authors: Pereira Lorena Izá 
Published: December 2024

O controle do território é um processo geográfico e histórico, apresentando singularidades no espaço e no tempo, estas resultantes de dinâmicas multiescalares em interação. Na América do Sul, a primeira manifestação da apropriação de terras para fins de acumulação do capital é a própria colonização. Desde então, a região tem experimentado diferentes regimes de controle do território. O Paraguai não está alheio a essa lógica. Desde o final da guerra da Tríplice Aliança (1870) o país é palco de sucessivos regimes de controle do território. Na atualidade a aceleração das mudanças climáticas e a institucionalização da questão ambiental promovem a criação de narrativas para justificar o controle de novos territórios e o estabelecimento de novos mercados, formando um novo regime de controle do território. Assim, o objetivo deste artigo é debater sobre a atualidade do processo de controle do território paraguaio, verificando se a agenda ambiental tem promovido um novo regime de controle do território no país. Após a utilização de metodologias qualitativas e quantitativas foi possível verificar uma modificação nas narrativas que legitimam a apropriação de terras no país em direção a agenda verde e que reverbera, em parte, nas territorialidades, mas não há uma mudança nas estratégias de acesso e controle. Enquanto isso, o Paraguai continua ocupando destaque na lista de países com a maior concentração fundiária do globo.
Бездомный, Голодный и Ясный: революционные псевдонимы и конструкция «Я + адъективный предикат»
Authors: Маркасова Елена Валерьевна 
Published: December 2024

Аннотация
В русском языке с 1820-х гг. формируется конструкция «Я + адъективный предикат», которая активно распространяется с середины XIX века, что объяснимо с точки зрения диахронической психологии. Перемены в привычных дискурсивных практиках, происходящие в XIX веке, отражают рост потребности человека в самоидентификации и самопрезентации. Эта модель самопрезентации складывалась параллельно с практикой искусственного номинирования автора. Семантика прилагательных, характеризующих «Я» в этой конструкции, сопоставима с семантикой псевдонимов-адъективов, возникших значительно раньше революционных событий. Влиянием языка революционной эпохи можно объяснить лишь происхождение псевдонимов, семантически связанных с футуристическими идеями строительства нового мира. В статье оспаривается распространенное мнение о росте количества псевдонимов-адъективов в первой трети XX в. как свидетельстве революционных воззрений их носителей и предлагается новая интерпретация происхождения «революционных» псевдонимов этого типа. Связь между именем и псевдонимом может быть неочевидной и неожиданной, но сам факт выбора адъектива в качестве псевдонима является знаковым.
Writing and publishing language studies in the Arab region [Khitabaat Journal]
Authors: Abdul-latif Emad 
Published: December 2024

Abstract
This article investigates both universal and relative aspects of sociolinguistic academic writing and reading. It engages with Wolfgang Klein’s (1989. Schreiben oder Lesen, aber nicht beides, oder: Vorschlag zur Wiedereinführung der Keilschrift mittels Hammer und Meißel. Zeitschrift für Literaturwissenschaft und Linguistik 74. 116–119) article. Klein starts from an implicit assumption that writing and reading are individual activities and suggests that (individual) writers must decrease their production to enable their (individual) readers to read it. I argue that the contemporary world transformed reading and writing from individual to institutional activities. This means that the importance and feasibility of contemporary academic research are not linked to the individualistic reading but rather to the institutional reading that transforms its results into policies, procedures, applications, and laws. Despite worldwide shared academic writing, reading, and publishing practices, the politics of writing and reading vary over time, disciplines and cultures. I argue that Arab knowledge production on sociolinguistics is highly affected by sociopolitical peculiarities, such as academic freedom restrictions, lack of resources and loose academic practices.
Navigating a national linguistics journal through local interests and global pressures: an editorial view on the problem of academic overproduction [Slovo a slovesnost]
Authors: Kaderka Petr , Sherman Tamah 
Published: December 2024

Abstract
This contribution responds to Wolfgang Klein’s text “Schreiben oder Lesen, aber nicht beides, oder: Vorschlag zur Wiedereinführung der Keilschrift mittels Hammer und Meißel” (Zeitschrift für Literaturwissenschaft und Linguistik 74, 1989, 116–119) from the perspective of long-term editors of a traditional national linguistics journal, Slovo a slovesnost (Czech Republic). After providing a historical context for the journal’s contemporary position, we examine the issues that currently require the greatest degree of adaptation on our part. These include the politics of textual genres in light of the need to enhance transparency of research practice, the ongoing struggle to both maintain and improve the quality of peer review, and the gatekeeping role of the academic journal. We conclude by stating that while Klein’s original premise that something must be done about the problem of overproduction is well-intentioned, the excessive growth in the number of published texts is basically unavoidable, and that we can only combat its detrimental effects by clearly establishing and enacting our priorities (including the support for national languages) as authors, readers and editors.
Toward un-WEIRDing academic publishing about language [Applied Linguistics]
Authors: Higgins Christina 
Published: December 2024

Abstract
In this commentary, I reflect on the shortcomings in representing linguistic knowledge in academic publishing. While Klein’s 1989 article Schreiben oder Lesen, aber nicht beides, oder: Vorschlag zur Wiedereinführung der Keilschrift mittels Hammer und Meißel calls attention to the overproduction of scholarly knowledge in the context of publish or perish ideologies, I invite us to consider how we distribute knowledge within the spaces of academic publishing with regard to global north and global south scholars and contexts. At present, scholarship about language is largely produced by scholars in WEIRD contexts, that is, western, educated, industrial, rich, democratic societies. This leads to limited outcomes in terms of what we can find out about the nature of language by virtue of excluding a majority of the world’s populations and contexts. As we go about questioning the purpose of academic publishing, we also need to consider how to better represent our findings in light of the narrowness of what we have researched.
Optical solitons to the fractional Kundu–Mukherjee–Naskar equation with time-dependent coefficients
Authors: Al-Askar Farah M. 
Published: December 2024

Abstract
In this article, we take into account the fractional space Kundu–Mukherjee–Naskar model with time-dependent coefficients (FSKMNE-TDCs). By incorporating time-dependent coefficients (TDCs) into the equation, researchers can better model systems that exhibit nonconstant or nonlinear behavior over time. This has important implications for understanding complex phenomena such as turbulence in fluid flow, quantum tunneling in particle physics, and time-varying electromagnetic fields. We apply the mapping method to obtain hyperbolic, elliptic, trigonometric and rational fractional solutions. These solutions are vital for understanding some fundamentally complicated phenomena. The obtained solutions will be very helpful for applications such as optical fiber wave propagation in a magnetized plasma, oceanic rogue waves, and ion-acoustic waves. Finally, we show how the M-truncated derivative order and TDCs affect the exact solution of the FSKMNE-TDCs.
Remediation of Ni2+ and Sr2+ ions from aqueous solutions by acacia gum/polyacrylic acid hydrogel reinforced with TiO2 nanoparticles
Authors: Sherbiny Sabah F. , Saad Ebtissam A. , Abdel Geleel Mohamed , Badawy Nagwa A. , Nasef Shaimaa M. 
Published: December 2024

Abstract
Globally, the environment and public health are progressively threatened due to water resource contaminants. For this purpose, a unique polyfunctional nanocomposite is created to remediate heavy metals from aqueous media. The basis of it is TiO2 composite nanoparticles (NPs) manufactured via embedding titanium oxide (TiO2) into acacia gum/acrylic acid (AG/AAc). Nanocomposite hydrogels, bearing different functional groups, are constructed employing a gamma irradiation approach that would operate as adsorbents to remove strontium (Sr2+) and nickel (Ni2+) ions from their wastes. The structure of the prepared hydrogel and its nanocomposites were confirmed by FTIR, whereas the morphology was characterized by SEM. XRD and EDX analysis confirms that the TiO2 NPs are successfully encapsulated into the prepared hydrogel. The presence of TiO2 enhances the thermal stability of the prepared hydrogel. Adsorption extent is evaluated comprehensively concerning temperature, contact time, adsorbent dosage, metal ion concentration, and pH. The physical connection between the adsorbent surface and metal ions is strengthened once TiO2 NPs are included in a copolymeric matrix, which enhances adsorption. Pseudo-second-order kinetics accurately depict the adsorption process, and the Freundlich isotherm provides the most relevant explanation of the equilibrium data. There is a demonstration that sorption is a spontaneous, feasible, and endothermic chemisorption process by examining a variety of thermodynamic parameters, including ΔH, ΔG, and ΔS.
Legal Forms and Reflexive Legal Forms: A New Approach to Reflexive Law
Authors: Ubilla Jaime 
Published: December 2024

Abstract
The possibility of steering social change through law has long been a central topic in the socio-legal literature. This article revisits the debate between Luhmann and Teubner on the matter and argues that it is possible to find a contextual and contingent common ground between their views. For this purpose, it proposes a new approach to reflexive law through a combination of Spencer-Brown’s “laws of form” and Luhmann’s theory of socio-legal evolution. The initial step is to develop the notion of “legal forms”, contending that it facilitates the observation of different combinations of normative and cognitive orientations of law thereby increasing our capacity for observing and assessing the interactions between law and society. It argues that the understanding and observation of “legal forms” sheds new light on the possibility and limits of social steering through law. This lays the foundation for introducing the notion of “reflexive legal forms,” that is, legal forms that have higher learning dispositions and are, therefore, better prepared to steer social change. Subsequently, the article applies the Luhmannian understanding of socio-legal evolution to explain the possible emergence and operation of reflexive legal forms as mechanisms that increase the probabilities of socio-legal evolution. Finally, it presents a case in which this new approach to reflexive law was applied: the conservation right, a new property right for environmental conservation recently enacted as law in Chile.
High prevalence of CTX-M-15 producing Shigella spp. isolated from patients with gastroenteritis in Northeast Iran
Authors: Khosravi Manizhe , Khosravi Fateme , Pouresmaeil Omid , Aryan Ehsan , Meshkat Zahra , Safdari Hadi , Farsiani Hadi 
Published: December 2024

AbstractShigellosis, a diarrheal disease caused by Shigella species, is a significant public health concern, particularly in developing countries with inadequate sanitation systems. This study aimed to investigate the patterns of antibiotic resistance, ESBL and AmpC genes, integrons, and enterotoxin genes in Shigella species isolated from patients with gastroenteritis in Northeast Iran. This cross-sectional study was conducted between January 2017 and December 2019 at a tertiary care hospital in Northeast Iran. A total of 110 Shigella isolates were collected from stool samples of patients with gastroenteritis. The isolates were identified using conventional biochemical tests and confirmed by PCR. The highest resistance rates were detected for ampicillin (88.2%) and cotrimoxazole (84.5%). Altogether 64.5% of isolates exhibited multidrug resistance however, ESBL and AmpC phenotypes were detected in 34.54% and 1.81% of isolates, respectively. Interestingly, blaCTX-M-15 and blaTEM were detected in all ESBL-positive isolates but integron class 1, 2, and 3 were identified in 97.3%, 76.4%, and 59.1% of isolates, respectively. The sen gene was present in 72.7% of the isolates. In this study CTX-M-15 production was detected in 31 strains of Shigella sonnei and in 7 strains of Shigella flexneri. The high prevalence of multidrug-resistant Shigella isolates is concerning and shows the need for continuous monitoring and rational use of antibiotics.
Genotype-First Analysis in an Unselected Health System–Based Population and Phenotypic Severity of COL4A5 Variants
Authors: Zellers McKenzie , Solanki Kaushal , Kelly Melissa A. , Murphy Karyn M. , Retterer Kyle , Kirchner H. Lester , Bucaloiu Ion Dan , Moore Bryn , Mirshahi Tooraj , Chang Alexander R. 
Published: December 2024

Key Points

In an unselected health system–based research study, we show that the phenotypic spectrum of X-linked Alport syndrome is wider than previously known.Kidney risks were lower for patients with p.Gly624Asp, a hypomorphic variant that is thought to have originated in Central and Eastern Europe.Many patients in this study had not been diagnosed with Alport syndrome, and consequently, many had not received appropriate testing and treatment.

Background
Our knowledge of X-linked Alport syndrome comes mostly from selected cohorts with more severe disease.

Methods
We examined the phenotypic spectrum of X-linked Alport syndrome in men and women with a genotype-based approach using data from the Geisinger MyCode DiscovEHR study, an unselected health system–based cohort with exome sequencing and electronic health records. Patients with COL4A5 variants reported as pathogenic or likely pathogenic in ClinVar, or protein-truncating variants, were each matched with up to five controls without COL4A3/4/5 variants by sociodemographics, diabetes diagnosis, and year of first outpatient encounter. Phenotypes examined included dipstick hematuria, bilateral sensorineural hearing loss, proteinuria, lower eGFR, and kidney failure.

Results
Of 170,856 patients, there were 29 hemizygous men (mean age 52 years [SD 20]) and 55 heterozygous women (mean age 59 years [SD 19]) with a pathogenic/likely pathogenic COL4A5 variant, including 48 with the hypomorphic variant p.Gly624Asp. Overall, penetrance (having any Alport syndrome phenotypic feature) was the highest for non-p.Gly624Asp variants (men: 94%, women: 85%) and intermediate for p.Gly624Asp (men: 77%, women: 69%) compared with controls (men: 32%, women: 50%). The proportion with kidney failure was the highest for men with non-p.Gly624Asp variants (44%) and intermediate for men with p.Gly624Asp (15%) and women with non-p.Gly624Asp variants (10%) compared with controls (men: 3%, women: 2%). Only 47% of patients with COL4A5 had completed albuminuria screening, and a minority were taking renin-angiotensin-aldosterone system inhibitors. Only 38% of men and 16% of women had a known diagnosis of Alport syndrome or thin basement membrane disease.

Conclusions
Using a genotype-first approach, we show that men and women with X-linked Alport syndrome are at higher risk of related phenotypic features with a wider spectrum of severity than has been described previously and variability by genotype.
Limitations of CDX and PDX methods using for cultivation of malignant ovarian neoplasms and their mathematical justification
Authors: Biktimirov T. R. , Shidin V. A. , Yanin V. L. , Kuzmenko M. Ya. , Karpova Ya. A. , Khalikova L. V. 
Published: December 2024

The article presents information on the most popular methods of culturing human malignant neoplasms to implement the obtained fundamental knowledge into the basis of translational research in oncology. A brief description of each of them allows you to decide on the possibility of including the technique in experimental work. The first approximation to the formation of the logic of the mathematical justification of the design of an experiment on modeling human malignant neoplasms is given.Also, using the example of a brief description of the original design of the experiment of scientists from the Khanty-Mansiysk State Medical Academy and the Tyumen State Medical University, the logic of constructing the design of such an experiment as part of the research work is demonstrated. An idea is formed about the need to include fundamental and translational stages in clinical experimental work as part of a unified strategy for responding to the great challenges of personalized medicine. An idea is formed about the need to include fundamental and translational stages in clinical experimental work as part of a unified strategy for responding to the great challenges of personalized medicine.