bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of 3,4-Dihydropyrano[c]chromenes Using Carbon Microsphere Supported Copper Nanoparticles (Cu-NP/C) Prepared from Loaded Cation Exchange Resin as a Catalyst
Authors: More Yogesh W. , Tekale Sunil U. , Kaminwar Nitishkumar S. , Kótai László , Pasinszki Tibor , Kendrekar Pravin S. , Pawar Rajendra P. 
Published: November 2018

Aim and Objective:
The present study was performed with the aim to develop an efficient and environmentally
benign protocol for the synthesis of biologically siginifcant 3, 4-dihydropyrano[c]chromenes using
a new catalytic material. The protocol involves the use of a reusable, environment friendly materials and solvents
with operational simplicity.

Materials and Methods:
Carbon microsphere supported copper nanoparticles (Cu-NP/C) prepared from loaded
cation exchange resin were synthesized, characterized with well versed analytical techniques such as XRD,
SEM and Raman spectroscopy and the synthesized material was used as a catalyst for the environmentally benign
synthesis of 3,4-dihydropyrano[c]chromenes.

Results:
The formation of carbon microsphere supported copper nanoparticles (Cu-NP/C) prepared from
loaded cation exchange resin was confirmed by XRD, SEM and Raman spectroscopy which was employed as a
heterogeneous material for the synthesis of 3,4-dihydropyrano[c]chromenes. The products formed were characterized
by the analysis of spectroscopic data - NMR, IR and mass. The safe catalytic system offers several advantages
including operational simplicity, environmental friendliness, high yield, and reusability of catalyst
and green chemical transformation.

Conclusion:
Herein we report an easy and efficient protocol for the one-pot synthesis of dihydropyrano[
c]chromenes using environmentally benign MCR approach in ethanol as the green solvent. The method
developed herein constitutes a valuable addition to the existing methods for the synthesis of titled compounds.
The Influence of Ultra-Low Concentrations of Potassium Anphen on the Bioenergetic Characteristics of Mitochondria
Authors: Irina Zhigacheva , Aleksandr Volodkin , Maksud Rasulov 
Published: November 2018

Background:
One of the main sources of ROS in stress conditions is the mitochondria. Excessive
generation of ROS leads to oxidation of thiol groups of proteins, peroxidation of membrane
lipids and swelling of the mitochondria. In this regard, there is a need to search for preparationsadaptogens
that increase the body's resistance to stress factors. Perhaps, antioxidants can serve as such
adaptogens. This work aims at studying the effect of antioxidant; the potassium anphen in a wide range
of concentrations on the functional state of 6 day etiolated pea seedlings mitochondria (Pisum sativum
L).

Methods:
The functional state of mitochondria was studied per rates of mitochondria respiration, by the
level of lipid peroxidation and study of fatty acid composition of mitochondrial membranes by chromatography
technique.

Results:
Potassium anphen in concentrations of 10-5 - 10-8 M and 10-13-10-16 prevented the activation of
LPO in the mitochondrial membranes of pea seedlings, increased the oxidation rates of NAD-dependent
substrates and succinate in the respiratory chain of mitochondria that probably pointed to the anti-stress
properties of the drug. Indeed, the treatment of pea seeds with the preparation in concentrations of 10-13
M prevented the inhibition of growth of seedlings in conditions of water deficiency.

Conclusion:
It is assumed that the dose dependence of the biological effects of potassium anphen and
the manifestation of these effects in ultra-low concentrations are due to its ability in water solutions to
form a hydrate containing molecular ensembles (structures).
Benchmarking Classification Models for Cell Viability on Novel Cancer Image Datasets
Authors: Özkan Akın , İşgör Sultan Belgin , Şengül Gökhan , İşgör Yasemin Gülgün 
Published: November 2018

Background:
Dye-exclusion based cell viability analysis has been broadly used in cell
biology including anticancer drug discovery studies. Viability analysis refers to the whole decision
making process for the distinction of dead cells from live ones. Basically, cell culture samples are
dyed with a special stain called trypan blue, so that the dead cells are selectively colored to
darkish. This distinction provides critical information that may be used to expose influences of the
studied drug on considering cell culture including cancer. Examiner’s experience and tiredness
substantially affect the consistency throughout the manual observation of cell viability. The
unsteady results of cell viability may end up with biased experimental results accordingly.
Therefore, a machine learning based automated decision-making procedure is inevitably needed to
improve consistency of the cell viability analysis.

Objective:
In this study, we investigate various combinations of classifiers and feature extractors
(i.e. classification models) to maximize the performance of computer vision-based viability
analysis.

Method:
The classification models are tested on novel hemocytometer image datasets which
contain two types of cancer cell images, namely, caucasian promyelocytic leukemia (HL60), and
chronic myelogenous leukemia (K562).

Results:
From the experimental results, k-Nearest Neighbor (KNN) and Random Forest (RF) by
combining Local Phase Quantization (LPQ) achieve the lowest misclassification rates that are
0.031 and 0.082, respectively.

Conclusion:
The experimental results show that KNN and RF with LPQ can be powerful
alternatives to the conventional manual cell viability analysis. Also, the collected datasets are
released from the “biochem.atilim.edu.tr/datasets/” web address publically to academic studies.
Experimental Comparison Between Three Types of Opaque Ventilated Facades
Authors: Stazi Francesca , Ulpiani Giulia , Pergolini Marianna , Magni Daniela , Di Perna Costanzo 
Published: November 2018

Background:The growing interest for the energy efficiency of building technologies has led the construction sector towards the adoption of Opaque Ventilated Facades (OVFs) as high-performance solutions for building systems.Objective:The aim of this study is to determine the optimal thermal inertia of the outer surface of ventilated facades with respect to the indoor comfort and the reduction of the outdoor overheating.Method:An experimental study was carried out in Central Italy (Mediterranean climate), by comparing the thermo-physical performance of three opaque ventilated façades, characterized by different positions of the mass (hollow bricks) within the air cavity. One has no mass and is enclosed by a Lightweight (L) cladding; one has an Internal Mass (IM) right adjacent to the insulation layer and an external lightweight cladding; the last one has an External Massive cladding (EM). The three prototypes (L, IM and EM walls), were installed on a test room and simultaneously monitored in the summer season.Result:The experimental outcomes demonstrate that the EM wall outperforms the others in terms of cooling efficiency, as the incoming heat fluxes towards the indoors are considerably reduced. Moreover, such a configuration led to the lowest surface temperatures on the outer slab, thus contributing to the mitigation of the external environmental overheating.Conclusion:Overall the External Mass (EM) solution was found to be the best choice, being beneficial for mitigating the outdoor surrounding temperatures and enhancing the buoyancy-driven ventilation.
Estimating the formation and thickness of a liquid layer on the surface of a packing material in biofiltration and their effects on gaseous toluene removal
Authors: Mansooria Ahmad Masoud , Higuchi Takashi 
Published: November 2018

Background:
Packing materials, which are used in biofiltration systems treating gaseous
volatile organic compounds, are expected to have optimal water content in their actual use. This is because
high volume of water increases the diffusion resistance while low water content decreases microbial
activity. Therefore the thickness of the liquid layer on the packing material needs to be identified
to determine the mass transfer process of target pollutants. However, it cannot be measured directly
due to the complicated surface structure of general packing materials.

Methods:
In this study, ideal biofiltration surfaces were prepared artificially by coating a plain membrane
surface with mono-cultured biomass and a known thickness of liquid layer. The sorption velocity
of gaseous toluene was then observed, within a considerable range of liquid thicknesses, on this biomass
surface. The velocity of water vaporization from a porous PVF poly-vinyl formal (PVF) material
was then measured. Finally, the relationship between thickness of liquid surface and the water
content of the PVF material was calculated based on the experimental results and a set of mathematical
models on vaporization.

Results:
There is an appropriate range for the thickness of the water layer thickness on the biomass at
the surface of packing material. In one case, this thickness was cited as approximately 0.1–0.2 mm for
gaseous toluene. The PVF material was thought to form such a thick water layer at around 50–60% of
its water content. The water content conditions that affect the formation of the water layer changed
when biomass grew on the surface of the PVF material. The range declined from around 70% for new
material to around 55% for biomass-rich material.

Conclusion:
This study quantitatively clarified the reason why there is optimal range of water content
for the packing material of biofiltration; i.e., appropriate liquid layer thickness at the surface of packing
materials is built by a certain range of water content.
Advancement in Nanotheranostics for Effective Skin Cancer Therapy: State of the Art
Authors: Akhter Md. Habban , Ahsan Mohamed Jawed , Rahman Mahfoozur , Anwar Siraj , Rizwanullah Md. 
Published: November 2018

:The skin cancer has become a leading concern worldwide as a result of high mortality rate. The treatment modality involves radiation therapy, chemotherapy or surgery. More often combination therapy of chemotherapeutic agents gives better solution over single chemotherapeutic agent. The Globocon report suggested that high incidence and mortality rate in skin cancer is growing day-to-day. This type of cancer is more prevalent in that area where a person is highly exposed to sunlight. The nanotechnology-based therapy is nowadays drawing attention and becoming a more important issue to be discussed. The nanotherapy of skin cancer is dealt with various approaches and strategies. The strategic based approaches imply nanoparticles targeting carcinoma cells, functionalized nanoparticles for specific targeting to cancer cells, receptor-mediated active targeting as nanoshells, nanostrutured lipid carriers, liposome, ethosome, bilosome, polymeric nanoparticle, nanosphere, dendrimers, carbon nanotubes, quantum dots, solid lipid nanoparticles and fullerenes which are highly efficient in specific killing of cancer cells. The passive targeting of chemotherapeutic agents is also helpful in dealing with carcinoma due to enhanced permeability and retention effect (EPR).:The article outlines nano-based therapy currently focused globally, and the outcomes of the therapy as well.
MENAPAKI FEMINISME GEOGRAFI PASCA POSITIVISTIK
Authors: Hastuti Hastuti 
Published: November 2018

Geografi maskulin telah mendominasi pemikiran geografi hingga dekade 90 an ditengah gegap gempitanya paham positivistik. McDowell dan Doreen (1996), bahwa ilmu spasial yang cenderung positivistik didukung oleh rasionalitas maskulin. Kajian geografis seharusnya menolak rasionalitas demikian bahkan dituntut untuk sensitif terhadap distribusi hubungan kekuasaan dalam proses penelitian. Geografi positivistik diakui memiliki kelemahan untuk menjelaskan tentang aktifitas maupun perilaku sosial, budaya, dan ekonomi manusia secara detail. Manusia adalah makhluk kompleks yang tidak selalu berpikir dan berperilaku linier sehingga dengan mudah dibuat sebagai model sebagaimana sering diterapkan pada pemikiran positivistik. Geografi yang menfokuskan kajian tentang manusia mengusulkan untuk adopsi analisis geografis yang sensitif agar mampu menangkap kehidupan manusia yang kompleks secara mendalam. Pemikiran post-positivistik dalam studi kualitatif menjadi alternatif analisa yang didukung oleh geograf feminis.
FENOMENA KESEHATAN REPRODUKSI PADA PELAJAR PUTRI DI SMA KOTA YOGYAKARTA
Authors: Setyawati Sriadi , Suparmini Suparmini , Widyastuti Mawanti 
Published: November 2018

AbstrakTujuan penelitian ini adalah untuk mengetahui fenomena kesehatan reproduksi remaja putri di Kota Yogyakarta. Penelitian ini adalah penelitian diskriptif kuantitatif. Metode penelitian yang digunakan adalah metode survei terhadap sampel penelitian. Populasi penelitian adalah pelajar putri di SMA Kota Yogyakarta. Jumlah populasi dalam penelitian ini sebanyak 600 pelajar putri dari tiga SMA di Kota Yogyakarta. Sampel penelitian berjumlah 90 pelajar putri, atau mengambil 15 persen dari populasi yang ada. Metode pengambilan sampel dengan ‘systematic sampling’. Analisis data menggunakan analisis diskriptif dengan tabel persentase.Hasil penelitian menunjukkan fenomena kesehatan reproduksi remaja putri di Kota Yogyakarta adalah sebagai berikut: Gaya pacaran responden sebagian besar yaitu sebanyak 90 persen mengarah ke free sex. Hamil sebelum menikah sebanyak 44,50 persen, seperti dinyatakan oleh responden yang menjawab pertanyaan tentang gaya pacaran teman – temannya. Hampir separuh yaitu 46,66 persen pernah melihat VCD porno. Hanya 19,89 persen responden menyatakan bahwa temannya pernah melakukan aborsi. Kata kunci: kesehatan reproduksi, pelajar putri
IDENTIFIKASI GERAKAN MASSA TERHADAP KERUSAKAN JALAN RAYA SUKOREJO-WELERI KILOMETER 6-16 KABUPATEN KENDAL
Authors: Widiyatmoko Wahyu , Purwantara Suhadi 
Published: November 2018

AbstrakPenelitian ini bertujuan mengetahui: (1) Karakteristik gerakan massa, meliputi tipe, jumlah, dan distribusi keruangan, (2) Faktor yang penyebab dan pemicu gerakan massa, (3) Jenis kerusakan jalan pada setiap gerakan massa. Populasi dalam penelitian ini adalah lahan di sekitar jalan raya Sukorejo-Weleri Km 6-16. Sampel diambil secara purposive sampling yaitu tempat yang mengalami gerakan massa. Analisis data dengan analisis deskriptif, tetangga terdekat, dan analisis tabel. Hasil penelitian: (1) Gerakan massa terdiri atas tiga tipe, yaitu longsor rotasional, rayapan, dan jatuhan. Pola distribusi menyebar. (2) Longsor rotasional disebabkan kemiringan lereng miring-curam, solum tanah tebal, kekar, dan batuan melapuk sangat lanjut. Pemicu utamanya pemotongan kaki perbukitan. Rayapan disebabkan kemiringan lereng miring-curam dan kembang kerut tanah. Pemicu utamanya pembuatan teras bangku. Jatuhan disebabkan kemiringan lereng curam-sangat curam dan banyak rekahan batuan. Pemicunya air hujan yang masuk melalui rekahan. (3) Kerusakan jalan disebabkan longsor rotasional adalah timbunan material dan amblesan, rayapan berupa retakan dan jalan bergelombang, jatuhan berupa timbunan batuan. Kata kunci: gerakan massa, jalan raya, kerusakan jalan
PERAN PEREMPUAN DALAM MENGHADAPI BENCANA DI INDONESIA
Authors: Hastuti Hastuti 
Published: November 2018

AbstrakPenduduk perempuan di Indonesia hampir separuh dari jumlah seluruh penduduk yakni setiap 100 perempuan terdapat 101 penduduk laki-laki (BPS, 2015). Komposisi penduduk itu dihadapkan dengan kondisi wilayah Indonesia yang rawan bencana. Bencana terus melanda muka bumi ini terutama di Indonesia berupa bencana alam maupun bencana sosial. Bencana melanda dengan menimbulkan kerugian harta benda bahkan mengancam keberlangsungan kehidupan dengan korban jiwa. Perempuan merupakan kelompok yang rentan ketika terjadi bencana. Upaya mengatasi bencana terus dikaji melalui kajian ilmiah, penelitian, maupun regulasi agar dapat ditekan dampak negatif yang meluas akibat bencana. Peran serta perempuan dalam menghadapi bencana mulai disadari sedemikian penting sehingga perempuan diharapkan dapat ikut mengurangi resiko bencana. Perempuan mulai dilibatkan dalam mitigasi bencana mulai dari pemulihan, rehabilitasi, sampai rekontruksi pasca bencana. Peningkatan peran perempuan dalam menghadapi bencana dilakukan melalui pendidikan, pelatihan agar perempuan memiliki pengetahuan dan kesadaran, serta keterampilan perempuan ketika menghadapi bencana. Dampak negatif ketika terjadi bencana diharapkan dapat ditekan melalui peningkatan peran perempuan dalam mengadapi bencana Kata kunci: perempuan, bencana
INTERRELASI SPASIAL BENTUKLAHAN DENGAN VEGETASI PADA LERENG TENGGARA VULKAN CIREMAI: TINJAUAN STUDI BIOGEOMORFOLOGI
Authors: Ashari Arif , Apriyeni Baiq Ahda Razula , Permana Deni , Safarudin Nor Rohmad 
Published: November 2018

AbstrakVulkan Ciremai merupakan vulkan soliter pada zona utara Jawa Barat. Sebagai vulkan strato aktif, Vulkan Ciremai memiliki kondisi geomorfologi yang kompleks. Pengaruh iklim tropis basah dengan curah hujan tahunan tinggi menghasilkan kekayaan biodiversitas vulkan ini, khususnya jenis vegetasi. Dalam dinamika lingkungan fisik, terdapat hubungan timbal balik antara bentuklahan dengan vegetasi dimana karakteristik bentuklahan mempengaruhi distribusi spasial dan kondisi vegetasi, sebaliknya vegetasi juga mempengaruhi perkembangan bentuklahan. Tulisan ini bertujuan mendeskripsikan: (1) pengaruh faktor geomorfologis terhadap distribusi vegetasi, (2) pengaruh vegetasi terhadap proses geomorfologi, pada lereng tenggara Vulkan Ciremai, dengan tinjauan biogeomorfologi khususnya pada tema ecological topology dan ecological memory. Data dikumpulkan melalui interpretasi citra penginderaan jauh, observasi, serta studi pustaka. Faktor geomorfologis berupa bentuklahan dan proses geomorfologi diketahui berpengaruh terhadap distribusi dan karakteristik vegetasi yang ditunjukkan oleh zonasi vegetasi yang linier terhadap bentuklahan. Pengaruh vegetasi terhadap proses geomorfologi terutama nampak pada variasi kemampuan vegetasi dalam mengendalikan laju erosi dan gerakan massa. Kata kunci: Biogeomorfologi, bentuklahan, vegetasi, Vulkan Ciremai
Analisis Spasial Tingkat Kerawanan Demam Berdarah Dengue untuk Pemetaan Daerah Prioritas Penanganan Menggunakan Sistem Informasi Geografis di Kecamatan Prambanan Kabupaten Klaten
Authors: Fadhilah Achmad , Sumunar Dyah Respati Suryo 
Published: November 2018

Penelitian ini bertujuan untuk mengetahui tingkat kerawanan demam berdarah dengue (DBD), penentuan daerah prioritas penanganan DBD, dan keterkaitan antara hujan terhadap kasus DBD di Kecamatan Prambanan Kabupaten Klaten. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kuantitatif berbantuan Sistem Informasi Geografis. Variabel penelitian meliputi: (1) kepadatan penduduk, (2) kepadatan permukiman, (3) penggunaan lahan, (4) jarak dari sungai, (5) jarak dari tempat penampungan sampah sementara, dan (6) angka kejadian DBD. Metode pengumpulan data yang digunakan: observasi, interpretasi citra penginderaan jauh, dan dokumentasi. Teknik analisis data yang digunakan adalah skoring, buffering, dan overlay. Hasil penelitian: terdapat tiga kelas tingkat kerawanan DBD yaitu tingkat kerawanan tinggi (321,37 ha), sedang (1806,55 ha), dan rendah (544,69 ha). Daerah prioritas utama penanganan DBD di Kecamatan Prambanan berdasarkan tingkat kerawanannya adalah Desa Kemudo dan Desa Kebondalem Lor. Jenis penanganan DBD yang diprioritaskan adalah pemberantasan sarang nyamuk dan menjaga kebersihan lingkungan. Curah hujan bulanan ternyata tidak berpengaruh signifikan terhadap kejadian DBD.
PENGEMBANGAN PARIWISATA ALAM BERBASIS LINGKUNGAN
Authors: Khotimah Nurul 
Published: November 2018

Abstrak Berbagai upaya untuk meningkatkan devisa negara dari aspek pariwisata, terutama pariwisata yang mengeksplorasi alam semakin digencarkan, baik wisata bahari, wisata pegunungan, wisata hutan, suaka alam, dan suaka margasatwa tanpa memperhatikan penurunan kualitas lingkungan yang mengancam kelestarian lingkungan itu sendiri . Penurunan kualitas lingkungan dapat dilihat dari unsur-unsur lingkungan abiotik, biotik, dan kultur yang terpengaruh oleh aktivitas pariwisata yang berlangsung, misalnya sampah, vandalisme, pendirian hotel, penginapan, perusakan biota alam, maupun dampak yang lain. Oleh karena itu pariwisata yang mengeksploitasi alam harus berbasis lingkungan dan pengelolaan yang terpadu, yaitu dengan perencanaan, pelaksanaan, pengawasan, dan evaluasi melalui pendekatan ekosistem. Seluruh kegiatan pariwisata harus mempertimbangkan keberadaan ekosistem yang ada demi kelestarian hidup yang ada dan menjaga kualitas lingkungan. Perlunya kebijakan dan strategi dalam pengelolaan wisata alam yang berbasis lingkungan bertujuan menjaga kelestarian lingkungan dan tetap mempertahankan berlangsungnya kegiatan pariwisata alam sehingga mampu mendongkrak devisa negara. Kata Kunci : pariwisata alam, lingkungan
URGENSI STUDI PERSEPSI RESIKO LINGKUNGAN DALAM PERENCANAAN PEMBANGUNAN WILAYAH (Belajar dari Kasus di Kota Seoul)
Authors: Hadi Bambang Syaeful 
Published: November 2018

Persepsi resiko (risk perception) merupakan aspek penting yang seringkali terlupakan dalam penyusunan dan implementasi pembangunan. Tulisan ini berusaha mengungkapkan urgensi persepsi resiko lingkungan masyarakat terhadap keberadaan suatu fasilitas dan bencana alam dan langkah-langkah studinya dalam perencanaan pembangunan wilayah, terutama dalam hal pembangunan fasilitas yang dilaksanakan oleh pemerintah berdasarkan kajian hasil penelitian Kwi-Gon Kim di Kota Seoul. Persepsi resiko dapat dipandang dan masuk dalam kajian geografi terutama dengan dengan sudut pandang ekologi. Tujuan studi persepsi resiko adalah membantu menganalisis resiko yang mungkin terjadi dan masukan dalam merumuskan pembuatan kebijakan dengan melakukan studi terhadap manusia dan bisofir. Bebagai disiplin ilmu seperti geografi, antropologi, psikologi mencoba mengkaji persepsi resiko dengan berbagai sudut pandang dan penekanan. Setiap wilayah/kota memiliki tingkat persepsi resiko yang berbeda. Faktor budaya, pandangan pribadi, pendidikan dan lingkungan dapat mempengaruhi persepsi resiko. Persepsi resiko ini penting untuk diketahui oleh para penentu kebijakan, karena tidak sedikit suatu pembangunan akan tidak mencapai manfaat yang diharapkan karena pengaruh persepsi resiko masyarakat. Penanganan masalah dampak bencana akibat keberadaan suatu fasilitas maupun bencana alam akan mengalami hambatan karena kekurangtepatan memahami persepsi resiko masyarakat terhadap lingkungan. Yogyakarta sebagai daerah yang mempunyai berbagai potensi bencana dapat menerapkan studi persepsi resiko dalam penanganan masalah bencana dan pembangunan kota. Persepsi resiko harus dipertimbangkan dalam pembuatan suatu keputusan pembangunan. Kata kunci: persepsi resiko, bencana, pembangunan wilayah
INOVASI IMPLEMENTASI E-HEALTH SEBAGAI MANIFESTASI SMART CITY DI KOTA YOGYAKARTA UNTUK MENINGKATKAN KUALITAS PELAYANAN KESEHATAN IBU DAN ANAK
Authors: Saharuddin Erni 
Published: November 2018

The high public demand for quality improvement on KIA becomes the basic fundamentals for the government of Yogyakarta to upgrade the quality and efficiency of KIA services. One of the implemented policies is the application of smart city in the health sector, primarily focusing on e-Health development. This research aims reviewing innovation in the implementation of e-Health in health centers Mantrijeron by employing a qualitative approach with interviews, observation, and documentation. The results showed that innovation of e-Health was divided into four categories: man, money, methods and machine. In terms of man (human resources) there were Simpus facilitation officer and adequate number of qualified human resources. Meanwhile money innovation occurred by adequate financial support from APBD, BOK and BLUD budget. Method innovation came in with the application of SOP in each service which also describes the associated use of Simpus. Machine innovation occurred through adequate computer devices, efforts to restore the hardware restoration efforts, routine network maintenance by a team of Service Level Agreement (SLA) and assistance from the Department of Communications, Information and Coding of Yogyakarta City.Keywords: e-Health, SIMPUS, Innovation, Service Quality