bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Cholangiolocellular Carcinoma Preoperatively Diagnosed With Typical Imaging Findings
Authors: Mochizuki Yoshihiro , Iimuro Yuji , Suzuki Osamu , Nagashima Yoji 
Published: April 2019

Introduction:Cholangiolocellular carcinoma (CoCC) is a rare primary liver neoplasm. A recent integrative genomic analysis has revealed that CoCC represents a distinct biliary-derived molecular entity. Several cases of CoCC have been reported so far, but accurate preoperative diagnosis was difficult in most cases.Case presentation:We report a case of 70-year-old woman with CoCC. Preoperative imaging findings revealed several typical signs of CoCC (i.e., thick early ring enhancement in the peripheral area of the tumor and its prolongation, vessel penetration through the tumor, no dilatation of the peripheral bile ducts, and dot-/band-like internal enhancement or a target appearance on contrast-enhanced magnetic resonance imaging). We strongly suspected CoCC from these preoperative imaging findings of the tumor and performed extended left hepatectomy. Pathologic diagnosis was CoCC, and the histologic findings such as peripheral highly cellular areas, central abundant hyalinized/edematous fibrotic stroma, and retained Glisson's sheath structures in the tumor, corresponded closely to each preoperative imaging finding. Immunohistochemical study revealed the tumor cells were positive for cytokeratin 7 and epithelial membrane antigen. The postoperative course was uneventful, and the patient is alive without recurrence for 15 months. The prognosis of CoCC is known to be better than that of cholangiocellular carcinoma, indicating the importance of preoperative differential diagnosis of these tumors.Conclusion:Even though preoperative diagnosis of CoCC is difficult because of its rarity, cautious investigation of preoperative typical imaging findings can possibly lead to accurate diagnosis of CoCC.
PENGARUH RETAIL SERVICE QUALITY TERHADAP MINAT BERKUNJUNG ULANG MALL Di SURABAYA MELALUI PERCEIVED QUALITY DAN CUSTOMER SATISFACTION SEBAGAI VARIABEL INTERVENING
Authors: Japarianto Edwin 
Published: April 2019

Perkembangan mall berdampak pada semakin meningkatnya pengunjung mall setiap tahun dan juga berdampak pada semakin tingginya persaingan dalam dunia tersebut khususnya di daerah Surabaya. Salah satu cara untuk dapat terus bersaing dan menigkatkan minat berkunjung ulang pengunjung ialah meningkatkan kualitas layanan. Meningkatkan kualitas layanan dapat membangun persepsi pelanggan terhadap mall tersebut yang nantinya akan berdampak pada kepuasan pengunjung serta akan meningkatkan minat pengunjung dalam melakukan kunjungan kembali. Penelitian ini bertujuan untuk menganalisa pengaruh Retail Service Quality terhadap Minat Berkunjung Ulang yang di-intervening oleh Perceived Quality dan Customer Satisfaction pada mall. Penelitian ini dilakukan dengan menyebarkan angket / kuesioner kepada 100 orang responden yang telah berkunjung ke mall. Metode penelitian yang digunakan merupakan metode analisa kuantitatif dengan menggunakan Smart PLS.Hasil dari penelitian menunjukkan Retail Service Quality berpengaruh signifikan terhadap Minat Berkunjung Ulang dan variabel Perceived Quality dan Customer Satisfaction mengintervening hubungan Retail Service Quality dan Minat Berkunjung Ulang.
Occupational exposure to inhaled nanoparticles: Are young workers being left in the dust?
Authors: Graczyk Halshka , Riediker Michael 
Published: April 2019

Abstract

Objectives
Occupational exposure to inhaled nanoparticles (NPs) represents a significant concern for worker health. Adolescent workers may face unique risks for exposure and resulting health effects when compared with adult workers.

Methods
This manuscript discusses key differences in risks for occupational exposures to inhaled NPs and resulting health effects between young workers and adult workers via an examination of both physiological and occupational setting factors.

Results
Previous studies document how adolescents often face distinct and unique exposure scenarios to occupational hazards when compared to adults. Moreover, they also face different and unpredictable health effects because biological functions such as detoxification pathways and neurological mechanisms are still developing well into late adolescence. Early exposure also increases the chances of developing long-latency disease earlier in life.
Taken together, adolescents’ rapid growth and development encompasses highly dynamic and complex processes. An aggravating factor is that these processes do not necessarily fall in line with legal classifications of adulthood, nor with occupational exposure limits created for adult workers.

Conclusions
The differences in exposures and health consequences from NPs on young workers are insufficiently understood. Research is needed to better understand what adolescent-specific mitigation strategies may be most suitable to address these risk factors.
Ultrasound grayscale image quality comparison between a 2D intracavitary transducer and a 3D intracavitary transducer used in 2D mode: A phantom study
Authors: Zhou Wei , Long Zaiyang , Tradup Donald J. , Stekel Scott F. , Browne Jacinta E. , Brown Douglas L. , Hangiandreou Nicholas J. 
Published: April 2019

AbstractPurposeIt is unclear if a 3D transducer with the special design of mechanical swing or 2D array could provide acceptable 2D grayscale image quality for the general diagnosis purpose. The aim of this study is to compare the 2D image quality of a 3D intracavitary transducer with a conventional 2D intracavitary transducer using clinically relevant phantom experiments.MethodsAll measurements were performed on a GE Logiq E9 scanner with both a 2D (IC5‐9‐D) and a 3D (RIC5‐9‐D) transducer used in 2D mode. Selection of phantom targets and acquisition parameters were determined from analysis of 33 clinical pelvic exams. Depth of penetration (DOP), contrast response, contrast of anechoic cylinders (diameter: 6.7 mm) at 1.5 and 4.5 cm depths in transverse planes, and in‐plane resolution represented by full‐width half‐maximum of pin targets at multiple depths were measured with transmit frequencies of 7 and 8 MHz. Spherical signal‐noise‐ratio (SNR) (diameter: 4 and 2 mm) at multiple depths were measured at 8 MHz.ResultsRIC5‐9‐D demonstrated <8% decrease in DOP for both transmit frequencies (7 MHz: 69.7 ± 8.2 mm; 8 MHz: 64.3 ± 7.8 mm) compared with those from IC5‐9‐D (7 MHz: 73.9 ± 4.4 mm; 8 MHz: 69.4 ± 7.8 mm). A decreased anechoic contrast was observed with a 4.5 cm depth for RIC5‐9‐D (7 MHz: 23.2 ± 1.8 dB, P > 0.05; 8 MHz: 17.7 ± 0.9 dB, P < 0.01) compared with IC5‐9‐D (7 MHz: 25.9 ± 1.2 dB; 8 MHz: 21.5 ± 0.8 dB). The contrast response and spatial resolution performance were comparable between the two transducers. RIC5‐9‐D showed comparable SNR of anechoic spheres compared to IC5‐9‐D.Conclusions2D images from a 3D probe exhibited comparable overall image quality for routine clinical pelvic imaging.
Enhancement of mass transfer from particles by local shear‐rate and correlations with application to drug dissolution
Authors: Wang Yanxing , Brasseur James G. 
Published: April 2019

AbstractWe analyze hydrodynamic enhancement of mass (or heat) release rate from small spherical particles within fluid flows from local flow shear‐rate, with application to drug dissolution. Combining asymptotic theories in the high/low shear Peclet number limits in Stokes flow with 205 carefully‐developed computational experiments, we develop accurate correlations for shear enhancement of Sherwood/Nusselt number (Sh/Nu) as a function of shear Peclet and Reynolds number (S*, Re
S). The data spanned S* from 0 to 500 and Re
S from 0 to 10. In Stokes flow our correlations are highly accurate over the entire S* range, whereas for finite Re
S < 1 accuracy is good for S* up to a few thousand. Shear enhancement results from highly three‐dimensional spiraling flow created by particle spin. We develop a model for particle slip velocity that is inserted into the Ranz/Marshall correlation to show that shear‐rate enhancement strongly dominates convection, a result important to drug dissolution.
High purity ethane/ethylene separation by gas phase simulated moving bed using ZIF‐8 adsorbent
Authors: Martins Vanessa F. D. , Ribeiro Ana M. , Kortunov Pavel , Ferreira Alexandre , Rodrigues Alírio E. 
Published: April 2019

AbstractGrowing population and demand for plastics and synthetic fluids in climate friendly environment sets the unprecedented industrial challenge to increase production of clean chemical precursors (e.g., ethylene) with reduced energy consumption and CO2 foot print. The production of polymer‐grade ethylene (>99.9%) from steam cracked gas or oil relies on a cascade of energy intensive distillations of gases. Therefore, in this work two simulated moving bed (SMB) cycles were employed to separate mixtures containing of about 40% of ethane and 60% of ethylene on zeolitic imidazole framework‐8 granulates. The separation cycles were performed with two desorbents with different relative adsorption strength. In the experiment, with carbon dioxide as desorbent, ethylene was obtained with 99.6% purity and 94.2% recovery, while in the experiment using propane as desorbent only 77.1% of ethylene is recovered with a purity of 82.7%. Indeed, it can be concluded that when CO2 is used as desorbent, the obtained productivity is higher. The mathematical SMB model and regions of separation were determined for each desorbent based on experimental data.
Determinants of objectively measured physical activity in rural East Timorese children
Authors: Spencer Phoebe R. , Sanders Katherine A. , Judge Debra S. 
Published: April 2019

AbstractObjectivesThe human juvenile period evolved as a period of learning and physical development in a family environment that subsidizes the costs of these processes. Children allocate energy to physical activity, maintenance, and growth. How energy is allocated has consequences for adult body size and other life‐history traits. In subsistence agriculture populations, where child contributions to the household economy are common and energy availability is low, trade‐offs in energy expenditure between activity and growth may help explain poor growth.MethodsUsing accelerometry, we measured physical activity over 2 years in 88 free‐living children aged 5‐19 years in two ecologically varying communities in rural Timor‐Leste. We model characteristics related to variation in activity, and subsequently, activity is modeled against growth, illness, and aspects of household and local ecology using linear mixed models.ResultsPhysical activity in Timorese children is characterized by high levels of moderate ( = 8.8 h/day), no sustained vigorous, and little sedentary activity ( = 4.6 h/day). Children in the mountainous community show a slight trade‐off between activity and growth (P = .077). Males down‐regulate both growth and activity relative to females. Variation in household characteristics does not predict child activity. Both activity and growth are lower in the mountainous community than in the flat, coastal community.ConclusionsHousehold demands on child behavior may constrain children's ability to moderate activity relative to nutritional status. Activity in this population is high relative to other subsistence populations, possibly because children face the dual pressures of contributing to household subsistence and attending school.
Protective effect of hydroxychloroquine on rheumatoid arthritis‐associated atherosclerosis
Authors: Shi Na , Zhang Shuangyue , Silverman Gregg , Li Mengtao , Cai Jun , Niu Haitao 
Published: April 2019

AbstractBackgroundPatients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease. We examined the effect of gut microbiota in a mouse model of RA that develops atherosclerosis.MethodsWe created three groups of K/BxN female mice that were positive for the anti‐glucose‐6‐phosphate isomerase (GPI) antibody: control diet (CD), high fat diet (HFD), and HFD with hydroxychloroquine (HFD + HCQ). Serological tests were used to detect the serum levels of total cholesterol (TCHO), low‐density lipoprotein cholesterol (LDL‐C), triglyceride (TG), high‐density lipoprotein cholesterol (HDL‐C), anti‐GPI antibody titers, and serum cytokines. Atherosclerotic plaque was determined by histological analysis, and gut microbiota were determined by 16sV4 sequencing.ResultsRelative to mice given the CD, those receiving the HFD had increased serum levels of LDL‐C, TCHO, and TG, decreased serum levels of HDL‐C, increased atherosclerotic lesions in the aortic root, and altered gut microbiota. Addition of HCQ to HFD decreased the serum levels of LDL‐C, TCHO, and TG, increased serum levels of HDL‐C, and decreased the atherosclerotic lesions in the aortic root. Mice receiving HFD + HCQ also had the greatest bacterial diversity among the three experimental groups. Moreover, HCQ treatment significantly increased the abundance of Akkermansia and Parabacteroides, and decreased the abundance of Clostridium sensu stricto cluster 1, and therefore may be responsible for the reduced RA‐associated atherosclerosis and dyslipidemia.ConclusionOur mouse model of RA indicated that HFD increased ankle width and aggravated atherosclerosis and dyslipidemia, and that HCQ alleviated the dyslipidemia and atherosclerosis, but had no effect on ankle width.
Triple regional anaesthesia technique in resection of left pleuropulmonary sarcoma and left subclavian artery bypass
Authors: Dillon D. , Johnston D. F. 
Published: April 2019

SummaryA 28‐year‐old woman presented for excision of a left‐sided pleuropulmonary sarcoma which was adherent to her left subclavian artery and mediastinum. A left upper lobe wedge resection was performed via a median sternotomy and a left carotid artery‐to‐left subclavian artery bypass was performed through a left supraclavicular incision. We report on a triple regional anaesthesia technique to provide postoperative analgesia. We inserted bilateral transverse thoracic plane catheters for continuous local anaesthetic infusion and performed bilateral subcostal transversus abdominus plane blocks for drain site analgesia. A left superficial cervical plexus block was performed to cover pain from the supraclavicular incision. Anteromedial chest wall blocks are an emerging analgesic technique for sternotomy and were successfully used as part of a combined regional anaesthetic for a patient undergoing complex thoracic surgery.
China's hegemonic intentions and trajectory: Will it opt for benevolent, coercive, or Dutch‐style hegemony?
Authors: Danner Lukas K. , Martín Félix E. 
Published: April 2019

AbstractChina's unprecedented economic growth led some scholars to conclude that it will replace the United States as the future global hegemon. However, China's intentions in exercising future global leadership are yet unknown and difficult to extrapolate from its often contradictory behaviour. A preliminary overview of China's island building in the South China Sea reveals its potentially coercive intentions. This inference is consistent with the analysis of those who prognosticate China's violent rise. Conversely and simultaneously, China's participation in peacekeeping operations and its global investments evince its benevolent hegemonic intentions, which are congruent with the argument of those who predict China's peaceful hegemonic ascent. Confronted with these divergent tendencies in China's recent international relations, and assuming its continued rise, it is, thus, essential to examine China's strategic intentions and how these may ultimately project its violent or peaceful hegemonic rise. This article argues that the “Third Way” or “Dutch‐style” hegemony is highly instructive in this context and, thus, should be examined and added to the existing debate on China's rise as either a benevolent or coercive hegemon. We argue that Dutch‐style hegemony may be the most viable way for China to proceed in its global hegemonic ascendancy.
Corruption and the business environment in Vietnam: Implications from an empirical study
Authors: Maruichi Daisuke , Abe Masato 
Published: April 2019

AbstractThis paper examines the effect of corruption on the business environment in Vietnam. Our survey of firms conducted in Vietnam suggests that corruption is perceived as the most impactful business obstacle for their operation. It was also found that corruption has a significant negative association with the overall satisfaction of the business environment in Vietnam, which supports the hypothesis that corruption has a “sand the wheel” effect on firms' business activities. Given these results, it is urgent that the Vietnamese public authorities accelerate efforts in mitigating this issue. Although this paper sheds light on the importance of corruption, it would be useful to conduct follow‐up studies examining corruption and its impact in more detail. Such studies could be conducted in segments that most severely suffer from corruption according to our survey, that is, medium‐sized enterprises in the hotel/restaurant and construction sectors, Hanoi based, and Vietnamese owned firms.
Small‐scale and multi‐species approaches for assessing litter decomposition and soil dynamics in high‐diversity forests
Authors: Martini Francesco , Xia Shang‐Wen , Yang Xiaodong , Goodale Uromi Manage 
Published: April 2019

Premise of the StudyThe relationship between tree species abundance and diversity and soil chemistry has been studied in several ecosystems and at different spatial scales. However, species‐specific assessments have mainly been conducted in temperate ecosystems and in monospecific settings, calling for studies from diverse, mixed forests from different ecosystems.MethodsIn a subtropical forest in southern China, under four dominant tree canopy species (Lithocarpus chintungensis,Castanopsis wattii,Schima noronhae, andManglietia insignis), we assessed species’ effect on inter‐ and intraspecific percentages of litter mass loss, and the effect of species on soil nutrients and soil microbial biomass.ResultsOur results show significant differences in litter decomposition for all four species; however, the percentage of litter mass loss was stable under different species. Microbial biomass and soil nutrients presented strong differences under different tree species. Species‐specific differences in soil characteristics were seen for carbon‐nitrogen‐phosphorus relationships. Surprisingly, the correlations between carbon and phosphorus and between nitrogen and phosphorus showed opposite slopes in soils collected under different tree species.DiscussionOur results provide insights into the importance of tree species identity in providing variety to ecosystem processes occurring on the forest floor. We recommend this methodological approach—combining analysis of litter decomposition, soil nutrient concentrations, and microbial biomass—when dealing with species‐rich forests.
Leipzig 1015 ce – a multiproxy study to reconstruct the palaeorelief of Leipzig's city centre
Authors: Grimm Ulrike , Heinrich Jürgen 
Published: April 2019

AbstractThe year 2015 marked the millennium of the first documentary evidence of the city of Leipzig as urbs Libzi. Inspired by this event the first digital elevation model (DEM 1015) from the palaeorelief at the time of the first settlement is modelled in two/three‐dimensions by applying geographic information system (GIS)‐technology. The article focuses on innovative multiproxy ideas to reconstruct the palaeorelief for a city centre. Thus, the topic of the project combines various scientific disciplines such as geomorphology and statistics. Qualitative data, mainly from archaeological excavations and geological drills, are linked by using GIS through surveying techniques. By applying the same method as for the DEM 1015, a recent DEM (DEM Today) is created. Furthermore, a comparison is conducted between this DEM Today and another recent DEM, which was generated with LiDAR data provided by the Staatsbetrieb Geobasisinformation und Vermessung Sachsen (GeoSN, State Operation Geobasisinformation and Surveying Saxony). A regression analysis and the descriptive comparison validate a close connection between the two recent DEMs. This supports the proposed methodology as being well suited to generate a visualization of the palaeorelief. However, models represent only a limited picture of reality. Undoubtedly, strong anthropogenic influences in the entire study area result in limiting factors which are hard to quantify. Therefore, the DEM 1015 shows the highest possible approximation of the ancient relief at the time of the first settlement. Nevertheless, the project supports further research on the landscape and settlement genesis at the study area. The DEM 1015 allows the investigation of the palaeorelief concerning geomorphological conditions during the Holocene. Furthermore, it is possible to draw inferences about how the environment has been shaped and structured by anthropogenic influences in this area over the last 1000 years. The research has the character of a case study that subsequently will open up opportunities to other areas.
Spectral and topological analyses of the cortical representation of the head position: Does hypnotizability matter?
Authors: Ibáñez‐Marcelo Esther , Campioni Lisa , Manzoni Diego , Santarcangelo Enrica L. , Petri Giovanni 
Published: April 2019

AbstractIntroductionThe aim of this exploratory study was to assess the EEG correlates of head positions (which have never been studied in humans) in participants with different psychophysiological characteristics, as encoded by their hypnotizability scores. This choice is motivated by earlier studies suggesting different processing of vestibular/neck proprioceptive information in subjects with high (highs) and low (lows) hypnotizability scores maintaining their head rotated toward one side (RH).MethodsWe analyzed EEG signals recorded in 20 highs and 19 lows in basal conditions (head forward) and during RH using spectral analysis, which captures changes localized to specific recording sites, and topological data analysis (TDA), which instead describes large‐scale differences in processing and representing sensorimotor information.ResultsSpectral analysis revealed significant differences related to head position for alpha 1, beta 2, beta 3, and gamma bands, but not to hypnotizability. TDA instead revealed global hypnotizability‐related differences in the strengths of the correlations among recording sites during RH. Significant changes were observed in lows on the left parieto‐occipital side and in highs in right frontoparietal region. Significant differences between the two groups were found in the occipital region, where changes were larger in lows than in highs.ConclusionsThis study reports finding of the EEG correlates of changes in the head posture for the first time, indicating that hypnotizability is related to the head posture representation/processing on large‐scale networks and that spectral and topological data analyses provide complementary results.