bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cost of alternative urban water supply and efficiency options in California
Authors: Cooley Heather , Phurisamban Rapichan , Gleick Peter 
Published: May 2019

Abstract
Urban communities, farms, businesses, and natural ecosystems depend upon adequate, reliable, and affordable supplies of clean water. As populations and economies grow and as climatic changes alter both water supply and demand, traditional options for meeting freshwater needs are becoming less available, reliable, and effective. As we approach peak water constraints on traditional water supplies, more efforts needed to reduce water demands through a wide range of conservation and efficiency technologies and policies, and to develop alternative, non-traditional water sources. A key factor in the adoption of these strategies is their economic feasibility; yet, only limited and often confusing data are available on their relative costs. To fill this gap, this analysis evaluates the costs of four groups of alternatives for urban supply and demand based on data and analysis in the California context: stormwater capture; water recycling and reuse; brackish and seawater desalination; and a range of water conservation and efficiency measures. We also describe some important co-benefits or avoided costs, such as reducing water withdrawals from surface water bodies or polluted runoff in coastal waterways. While difficult to quantify, such benefits are economically relevant, and we highlight areas where further research and analysis are needed to improve estimates presented here. All of the water-use efficiency options are far less costly than traditional or alternative supply systems with the exception of some of the most expensive landscape water reduction options. The water treatment and reuse systems and the urban stormwater capture projects are more costly per unit of water produced but still less expensive than seawater desalination—the most expensive option evaluated.
Aquaculture-induced boundary circulation and its impact on coastal frontal circulation
Authors: Xuan Jiliang , He Yuqing , Zhou Feng , Tang Cheng , Zheng Xiangyang , Liu Hui , Yu Liangju , Chen Jianfang 
Published: May 2019

Abstract
With the development of coastal suspended aquaculture industry, aquaculture facilities have extended into the open sea to depths of up to 30 m. This practice will likely affect the natural ocean circulation in such areas. For a case study in the high-density aquaculture region of the coastal Yellow Sea, an aquaculture-induced boundary circulation (ABC) is identified and its effects on the background frontal circulation and cross-shore nutrient supply are examined. The ABC is composed of a southward along-boundary current and a counterclockwise cross-boundary cell. The southward along-boundary current (∼5 cm s−1) along with the natural frontal current (∼5 cm s−1) forms a strong coastal current (∼10 cm s−1) along 20–30 m isobaths. The counterclockwise cross-boundary cell exhibits the opposite direction to the natural clockwise cross-frontal cell in the frontal area, which reduces the cross-shore nutrient supply by nearly 25%. Our results suggest that aquaculture boundaries and densities should be considered when planning high-density aquaculture activities.
Cs3Bi2I9 as high-performance electrode material achieving high capacitance and stability in an economical supercapacitor
Authors: Adams Keir , Mallows John , Li Tianyue , Kampouris Dimitrios , Thijssen Job H J , Robertson Neil 
Published: May 2019

Abstract
Supercapacitors are well-known as promising energy storage devices capable of bridging the gap between conventional electrolytic capacitors and batteries to deliver both high power and energy densities for applications in electric vehicles and a smart energy grid. However, many reported instances of high-capacitance pseudocapacitors employ strong Faradaic reactions that hinder fast charge–discharge cycles and long-term stability, limiting their commercial viability. In this study, we utilise an economical and solution-processable procedure to fabricate a Cs3Bi2I9-based symmetric supercapacitor employing both electric double layer capacitance and pseudocapacitance with an aqueous NaClO4 electrolyte to deliver an outstanding device areal capacitance of 2.4 F cm−2 and specific capacitance of 280 F g−1. The Cs3Bi2I9 device achieves an excellent 88% capacitance retention after 5000 charge–discharge cycles, proving its long-term cycle stability and promise as a practical supercapacitor. We characterise the time-dependent charge storage mechanisms through cyclic voltammetry and electrochemical impedance spectroscopy to find that electrostatic charge accumulation predominates at high potentials (0.3–0.6 V) whereas weak, Faradaic charge adsorption and pore penetration bolster charge storage at lower potentials (0.0–0.2 V).
The organization of nuclear ribosomal DNA in gnetophytes – physically separate and physically linked arrangements of 35S and 5S genes. A commentary on: ‘Remarkable variation of ribosomal DNA organization and copy number in gnetophytes, a distinct lineage of gymnosperms’
Authors: Renner Susanne , Sousa dos Santos Aretuza 
Published: May 2019

This article comments on:
Wencai Wang, Tao Wan, Hannes Becher, Alena Kuderova, Ilia J. Leitch, Sonia Garcia, Andrew R. Leitch and Aleš Kovařík. 2019. Remarkable variation of ribosomal DNA organization and copy number in gnetophytes, a distinct lineage of gymnosperms. Annals of Botany 123(5): 767–781.
Near-neighbour optimal outcrossing in the bird-pollinated Anigozanthos manglesii
Authors: Ayre Bronwyn M , Roberts David G , Phillips Ryan D , Hopper Stephen D , Krauss Siegfried L 
Published: May 2019

Abstract

Background and Aims
In plants, the spatial and genetic distance between mates can influence reproductive success and offspring fitness. Negative fitness consequences associated with the extremes of inbreeding and outbreeding suggest that there will be an intermediate optimal outcrossing distance (OOD), the scale and drivers of which remain poorly understood. In the bird-pollinated Anigozanthos manglesii (Haemodoraceae) we tested (1) for the presence of within-population OOD, (2) over what scale it occurs, and (3) for OOD under biologically realistic scenarios of multi-donor deposition associated with pollination by nectar-feeding birds.

Methods
We measured the impact of mate distance (spatial and genetic) on seed set, fruit size, seed mass, seed viability and germination success following hand pollination from (1) single donors across 0 m (self), <1 m, 1–3 m, 7–15 m and 50 m, and (2) a mix of eight donors. Microsatellite loci were used to quantify spatial genetic structure and test for the presence of an OOD by paternity assignment after multi-donor deposition.

Key results
Inter-mate distance had a significant impact on single-donor reproductive success, with selfed and nearest-neighbour (<1 m) pollination resulting in only ~50 seeds per fruit, lower overall germination success and slower germination. Seed set was greatest for inter-mate distance of 1–3 m (148 seeds per fruit), thereafter plateauing at ~100 seeds per fruit. Lower seed set following nearest-neighbour mating was associated with significant spatial genetic autocorrelation at this scale. Paternal success following pollination with multiple sires showed a significantly negative association with increasing distance between mates.

Conclusions
Collectively, single- and multi-donor pollinations indicated evidence for a near-neighbour OOD within A. manglesii. A survey of the literature suggests that within-population OOD may be more characteristic of plants pollinated by birds than those pollinated by insects.
Competitively mediated changes in male toad calls can depend on call structure
Authors: Stirman Rebecca , Pfennig Karin S 
Published: May 2019

Abstract
Males of many species aggregate in large groups where they signal to attract females. These large aggregations create intense competition for mates, and the simultaneous signaling by many individuals can impair any given male’s ability to attract females. In response to this situation, male signals can be modified, either evolutionarily or facultatively, such that the detectability of the signal is enhanced. The way in which signals are modified varies among even closely related species, yet few studies have evaluated what causes such variation. Here, we address this issue using male spadefoot toads (Spea multiplicata and Spea bombifrons), which call to attract females. Using data from natural populations, we examined if, and how, male calls of 3 different call types (S. multiplicata with a slow call, S. bombifrons with a slow call, and S. bombifrons with a fast call) varied depending on competition with other males. We found that in both call types consisting of slow calls, call pulse rate decreased with increasing competition. By contrast, in the call type consisting of fast calls, call rate decreased with increasing competition. Moreover, we found that the relationship between competition and male call effort—a measure of the energy that males expend in calling––differed between the call types. Such variation in male signals in response to competition can have important implications for explaining diversity in male signals and patterns of sexual selection.
Stop-gain mutations in UBAP1 cause pure autosomal-dominant spastic paraplegia
Authors: Lin Xiang , Su Hui-Zhen , Dong En-Lin , Lin Xiao-Hong , Zhao Miao , Yang Can , Wang Chong , Wang Jie , Chen Yi-Jun , Yu Hongjie , Xu Jianfeng , Ma Li-Xiang , Xiong Zhi-Qi , Wang Ning , Chen Wan-Jin 
Published: May 2019

Abstract
Hereditary spastic paraplegias refer to a heterogeneous group of neurodegenerative disorders resulting from degeneration of the corticospinal tract. Clinical characterization of patients with hereditary spastic paraplegias represents progressive spasticity, exaggerated reflexes and muscular weakness. Here, to expand on the increasingly broad pools of previously unknown hereditary spastic paraplegia causative genes and subtypes, we performed whole exome sequencing for six affected and two unaffected individuals from two unrelated Chinese families with an autosomal dominant hereditary spastic paraplegia and lacking mutations in known hereditary spastic paraplegia implicated genes. The exome sequencing revealed two stop-gain mutations, c.247_248insGTGAATTC (p.I83Sfs*11) and c.526G>T (p.E176*), in the ubiquitin-associated protein 1 (UBAP1) gene, which co-segregated with the spastic paraplegia. We also identified two UBAP1 frameshift mutations, c.324_325delCA (p.H108Qfs*10) and c.425_426delAG (p.K143Sfs*15), in two unrelated families from an additional 38 Chinese pedigrees with autosomal dominant hereditary spastic paraplegias and lacking mutations in known causative genes. The primary disease presentation was a pure lower limb predominant spastic paraplegia. In vivo downregulation of Ubap1 in zebrafish causes abnormal organismal morphology, inhibited motor neuron outgrowth, decreased mobility, and shorter lifespan. UBAP1 is incorporated into endosomal sorting complexes required for transport complex I and binds ubiquitin to function in endosome sorting. Patient-derived truncated form(s) of UBAP1 cause aberrant endosome clustering, pronounced endosome enlargement, and cytoplasmic accumulation of ubiquitinated proteins in HeLa cells and wild-type mouse cortical neuron cultures. Biochemical and immunocytochemical experiments in cultured cortical neurons derived from transgenic Ubap1flox mice confirmed that disruption of UBAP1 leads to dysregulation of both early endosome processing and ubiquitinated protein sorting. Strikingly, deletion of Ubap1 promotes neurodegeneration, potentially mediated by apoptosis. Our study provides genetic and biochemical evidence that mutations in UBAP1 can cause pure autosomal dominant spastic paraplegia.
Target Setting in Tournaments: Theory and Evidence from China
Authors: Li Xing , Liu Chong , Weng Xi , Zhou Li-An 
Published: May 2019

AbstractMotivated by the prevalence of economic targets at all levels of territory administration in China, this article proposes a Tullock contest model to study optimal target setting in a multi-layered tournament-based organisation. In our model, targets are used by upper-level officials to convey the importance of economic growth and incentivise subordinates in the tournaments. Our model predicts a top-down amplification of economic growth targets along the jurisdiction levels, which explains the observed pattern in China. Using both provincial and prefectural-level data, we test the model predictions and find consistent evidence.
The Witch-cleric Stereotype in a Seventeenth-Century Lutheran Context*
Authors: Rowlands Alison 
Published: May 2019

Abstract
This article enhances our understanding of the development and dynamism of early modern witch stereotypes by focusing on the stereotype of the witch-cleric, the Christian minister imagined by early modern people as working for the devil instead of God, baptizing people into witchcraft, working harmful magic and even officiating at witches’ gatherings. I show how this stereotype first developed in relation to Catholic clerics in demonology, print culture and witch-trials, then examine its emergence in relation to Protestant clerics in Germany and beyond, using case studies of pastors from the Lutheran territory of Rothenburg ob der Tauber from 1639 and 1692 to explore these ideas in detail. I also offer a broader comparison of beliefs about Protestant witch-clerics and their susceptibility to formal prosecution with their Catholic counterparts in early modern Germany, showing that cases involving Protestant witch-clerics were part of a cross-confessional phenomenon that is best understood in a comparative, Europe-wide perspective. In addition to showing how the witch-cleric stereotype changed over time and spread geographically, I conclude by arguing that three distinct variants of this stereotype had emerged by the seventeenth century: the Catholic ‘witch-priest’ and Protestant ‘witch-pastor’ (who were supposedly witches themselves) and the overzealous clerical ‘witch-master’, who was thought to do the devil’s work by helping persecute innocent people for witchcraft. Despite these stereotypes, however, relatively few clerics of either confession were tried and executed as witches; overall, patriarchy worked to protect men of the cloth from the worst excesses of witch persecution.
Association of Severe Influenza Virus Infections With CD226 (DNAM-1) Variants
Authors: Redlberger-Fritz Monika , Vietzen Hannes , Puchhammer-Stöckl Elisabeth 
Published: May 2019

AbstractNatural killer (NK)-cell response against influenza viruses partly depends on expression of CD112, a ligand for NK-cell receptor CD226 (DNAM-1). We analyzed whether particular CD226 variants were associated with influenza disease severity. Comparison between 145 patients hospitalized with severe influenza at intensive care units (ICU) with 139 matched influenza-positive outpatients showed that presence of the rs763362 G allele (GG, AG) was associated with occurrence of severe influenza infections (P = .0076). Also, a higher frequency of rs727088 G and rs763361 T alleles was observed in the ICU group. Thus, CD226 variants may contribute to the severity of influenza virus disease.
Post-marketing observational study of everolimus in patients with unresectable or metastatic renal cell carcinoma in Japan
Authors: Akaza Hideyuki , Kurihara Ryohei , Katsura Aiko , Harumiya Miki , Ushida Naoko 
Published: May 2019

Abstract

Objective
To confirm the safety and efficacy of everolimus in patients with unresectable or metastatic RCC.

Methods
Patients with unresectable or metastatic RCC were included and were followed for up to 1 year from the start of everolimus. The study was conducted at 618 investigational sites in Japan from March 2010 through January 2018. Safety endpoints include adverse events (AEs), and efficacy endpoints were presence/absence of tumor response, progression-free survival (PFS), and overall survival (OS) rate.

Results
Of 1694 patients, majority were male (76.33%). Overall, 97.64% of patients experienced AEs and 49% reported serious AEs. The most common serious AEs (incidence of ≥ 5%) include malignant neoplasm progression (21.13%) and interstitial lung disease (10.86%). The incidences of adverse reactions of priority investigation items are as follows: interstitial lung disease (27.74%), infections (11.57%), stomatitis (45.45%), increased in serum creatinine (5.61%), hyperglycemia (14.23%), exacerbation of renal impairment (26.14%), and exacerbation of hepatic impairment (1.15%). The overall tumor response rate was 6.81% with 0.08% CR, and 6.73% PR. The SD was reported in 68.74% of patients. The median PFS was 196 days (95% CI: 181–216 days). The 365-day cumulative OS rate was 82.42%.

Conclusions
The acceptable safety and efficacy findings in patients with unresectable or metastatic RCC were confirmed in this study, and are similar to those of pivotal study, which led to the approval, and no new issues were detected. There were no safety or efficacy issues in special populations including elderly and patients with renal/hepatic impairment.
Forest Sector Research and Development Capacity
Authors: McGinley Kathleen A , Guldin Richard W , Cubbage Frederick W 
Published: May 2019

AbstractCurrent trends in the nation’s forest-sector research capacity were analyzed in terms of funding and number of scientists, and compared with prior data in the National Research Council’s 2002 report, National Capacity in Forestry Research. The total number of professors at institutions with academic programs accredited by the Society of American Foresters, research scientists at the USDA Forest Service, and forest researchers in forest industry decreased approximately 12 percent since 2002. In 2016, there were an estimated 1,224 professors and 540 Forest Service research scientists, for a total of 1,764 scientists. Total estimated research funding in 2015 for universities, private sector, and USDA Forest Service, including appropriations from federal grant programs from the USDA National Institute for Food and Agriculture, National Science Foundation, National Aeronautics and Space Administration, and Department of Energy was US$598 million—a nominal increase over 2002, but a decrease when accounting for inflation. The proportion of reported scientists’ disciplines shifted notably from production subjects to broader ecosystem services and forest health subjects, as well as from more applied to more fundamental or basic research. The data indicated that the nation’s forest research capacity continues to erode, leading to declines in research development and innovation, and putting at increasing risk the future health and productivity of America’s forests.
So Many Questions, So Little Time: Integrating Adaptive Inventories into Public Opinion Research
Authors: Montgomery Jacob M , Rossiter Erin L 
Published: May 2019

Abstract
One of the most difficult tasks facing survey researchers is balancing the imperative to keep surveys short with the need to measure important concepts accurately. Not only are long batteries prohibitively expensive but lengthy surveys can also lead to less informative answers from respondents. Yet, scholars often wish to measure traits that require a multi-item battery. To resolve these contradicting constraints, we propose the use of adaptive inventories. This approach uses computerized adaptive testing methods to minimize the number of questions each respondent must answer while maximizing the accuracy of the resulting measurement. We provide evidence supporting the utility of adaptive inventories through an empirically informed simulation study, an experimental study, and a detailed case study using data from the 2016 American National Election Study (ANES) Pilot. The simulation and experiment illustrate the superior performance of adaptive inventories relative to fixed-reduced batteries in terms of precision and accuracy. The ANES analysis serves as an illustration of how adaptive inventories can be developed and fielded and also validates an adaptive inventory with a nationally representative sample. Critically, we provide extensive software tools that allow researchers to incorporate adaptive inventories into their own surveys.
Large covariance matrices: accurate models without mocks
Authors: O’Connell Ross , Eisenstein Daniel J 
Published: May 2019

Abstract
Covariance matrix estimation is a persistent challenge for cosmology. We focus on a class of model covariance matrices that can be generated with high accuracy and precision, using a tiny fraction of the computational resources that would be required to achieve comparably precise covariance matrices using mock catalogues. In previous work, the free parameters in these models were determined using sample covariance matrices computed using a large number of mocks, but we demonstrate that those parameters can be estimated consistently and with good precision by applying jackknife methods to a single survey volume. This enables model covariance matrices that are calibrated from data alone, with no reference to mocks.
Turbulence decay in the density-stratified intracluster medium
Authors: Shi Xun , Zhang Congyao 
Published: May 2019

Abstract
Turbulence evolution in a density-stratified medium differs from that of homogeneous isotropic turbulence described by the Kolmogorov picture. We evaluate the degree of this effect in the intracluster medium (ICM) with hydrodynamical simulations. We find that the buoyancy effect induced by ICM density stratification introduces qualitative changes to the turbulence energy evolution, morphology, and the density fluctuation–turbulence Mach number relation, and likely explains the radial dependence of the ICM turbulence amplitude as found previously in cosmological simulations. A new channel of energy flow between the kinetic and the potential energy is opened up by buoyancy. When the gravitational potential is kept constant with time, this energy flow leaves oscillations to the energy evolution, and leads to a balanced state of the two energies where both asymptote to power-law time evolution with slopes shallower than that for the turbulence kinetic energy of homogeneous isotropic turbulence. We discuss that the energy evolution can differ more significantly from that of homogeneous isotropic turbulence when there is a time variation of the gravitational potential. Morphologically, ICM turbulence can show a layered vertical structure and large horizontal vortical eddies in the central regions with the greatest density stratification. In addition, we find that the coefficient in the linear density fluctuation–turbulence Mach number relation caused by density stratification is in general a variable with position and time.