bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early-Life Stress Influences the Transcriptional Activation of Alpha-2A Adrenergic Receptor and Associated Protein Kinase A Signaling Molecules in the Frontal Cortex of Rats
Authors: Ali Sarah , Dwivedi Yogesh 
Published: November 2024

AbstractEarly life is a highly sensitive period associated with profound changes in brain structure and function. Adverse experiences of early-life stress (ELS) are prominent risk factors for the precipitation of major depressive disorder (MDD). In recent years, dysfunction of the central noradrenergic (NA) system and subsequent deficits in norepinephrine (NE) signaling have gained increasing attention in the pathophysiology of MDD. However, the role of the α-2A adrenergic receptor and its downstream second messenger signaling system has not been investigated in connection to early-life stress-induced depression, limiting valuable insights into neurobiological mechanisms underlying this disorder. In this study, we used maternal separation (MS) as a rodent model of ELS to investigate whether ELS-induced depressive behavior is related to the α-2A adrenergic receptor and its associated second messenger signaling cascade. To do so, we studied expression levels of the α-2A adrenergic receptor (Adra2a), G alpha proteins (stimulatory subunit-Gαs [Gnas] and inhibitory subunit-Gαi [Gnai1 and Gnai2]), and downstream protein kinase A (PKA) catalytic [Prkarcα and Prkarcβ] and regulatory subunits [Prkar1α, Prkar1β, Prkar2α, and Prkar2β]) in the frontal cortex (FC) of MS rats. We found reduced sucrose preference in MS animals, along with reduced transcript levels of Adra2a, Gnai2, Prkar1β, and Prkarcβ. These findings suggest that ELS exposure may contribute to depression symptomatology via alterations in the expression of key genes involved in the NA system, highlighting potential mechanisms underlying ELS-induced depressive behavior.
Metaphorical Mirrors: Aesthetic Reflections from Plato to Nietzsche (and Beyond)
Authors: Halliwell Stephen 
Published: November 2024

Abstract
This article weaves together three main strands: first, the ambiguities of mirror metaphors in relation to concepts of artistic representation and expression; secondly, the double-sided and sometimes paradoxical influence of Plato in this area of aesthetics; thirdly, the need to interpret long-lasting metaphors in the history of ideas not as static figures of speech but as dynamic tropes which shift in sense and implications with changes of context. In constructing and exploring this thematic configuration of mirrors, metaphors, and Plato, the chief concern is to draw out—via a small selection of texts, including passages from Schopenhauer and Nietzsche—some underappreciated complexity in the various classical traditions that have contributed to aesthetics and philosophy of art.
The heart can lie: a preliminary investigation of the role of interoception and theory of mind in deception
Authors: Makowski Dominique , Lau Zen J. , Pham Tam , Te An Shu , Kirk Stephanie , Liauw Claudia , Chen S. H. Annabel 
Published: November 2024

AbstractWhile a large part of the deception literature focuses on lying detection, the factors contributing to one’s ability to lie remain unclear. The present study examined the contribution of Theory of Mind (ToM) and interoception on our ability to lie using a directed lie paradigm with two conditions (“Interrogation” and “Polygraph”), designed to enhance each of the two mechanisms. Given the relatively small sample size (n = 26 × 40 trials), special steps were taken to avoid false positives. Our results suggest that various facets of interoceptive abilities are positively related to the self-rated confidence in one’s own lies, especially when under the belief that bodily signals are being monitored (i.e., in the “Polygraph” condition). Beyond providing evidence for the role of the body in lying and raising interesting questions for deception science, these results carry practical implications for criminology and lie detection protocols.
Solitary Peutz–Jeghers polyp harboring a focus of high-grade dysplasia in the colon: a case report and literature review
Authors: Maeda Takato , Yoshizawa Tadashi , Oyama Takao , Nakagawa Satoru , Murai Yasuhisa , Machida Ryuma , Ishidoya Nao , Sakamoto Juichi , Iwamura Hideki , Sakuraba Hirotake 
Published: November 2024

Abstract
A solitary Peutz–Jeghers (PJ) polyp is a rare hamartomatous lesion without an associated PJ syndrome. However, little is known regarding malignancy arising in solitary PJ polyps. Here, we report a case of a solitary colonic PJ polyp with focal dysplasia. A 45-year-old asymptomatic man underwent total colonoscopy following a positive fecal occult blood test. The patient had no history of mucocutaneous pigmentation or family history of PJ syndrome. A 20 mm erythematous pedunculated polyp was observed in the sigmoid colon. Magnified endoscopy revealed a tubular or branch-like pit pattern with localized areas of irregular pits. These findings were suggestive of colorectal adenoma with high-grade dysplasia, and endoscopic mucosal resection was performed. Histopathological examination revealed arborizing proliferation of hyperplastic epithelia with smooth muscle bundles. In addition, a small number of irregular crypts with high-grade dysplasia were observed in the hyperplastic epithelium. Based on these histological findings, we finally diagnosed the patient with a solitary colonic PJ polyp with high-grade dysplasia. The present case suggests that solitary colonic PJ polyps may harbor dysplastic changes and require pathological evaluation with en bloc resection of the polyps.
Generation of human induced pluripotent stem cell lines derived from patients of cystic biliary atresia
Authors: Ge Ningxin , Suzuki Kan , Sato Iori , Noguchi Michiya , Nakamura Yukio , Matsuo-Takasaki Mami , Fujishiro Jun , Hayashi Yohei 
Published: November 2024

AbstractBiliary atresia (BA), resulting from abnormal development of the liver’s internal or external bile ducts, can lead to liver damage and potentially fatal cirrhosis. Type I cystic biliary atresia is a relatively uncommon, but clinically significant variant of BA. It is critical to develop experimental models of BA to examine the etiology and pathogenesis, which remain elusive, and to develop future therapeutics. Here, we have successfully generated a panel of human induced pluripotent stem cells (hiPSCs) from five Japanese patients carrying type I cystic BA. These hiPSC lines exhibited characteristics of self-renewal and pluripotency. These cells held normal karyotypes mostly, but one of them carried hemizygous deletions, the clinical significance of which is unknown yet. Whole genome sequence analysis indicated that some of the mutations or single nucleotide polymorphisms (SNPs) commonly found in these patients are related to hepatobiliary abnormality. Given the limited understanding of the molecular pathogenesis of cystic BA, attributed to unknown factors of genetic and environmental causes, these cellular resources will be instrumental in replicating disease phenotypes and in advancing novel therapies for this disease.
Process–Material–Performance Trade-off Exploration of Materials Sintering with Machine Learning Models
Authors: Kakanuru Padmalatha , Terway Prerit , Jha Niraj , Pochiraju Kishore 
Published: November 2024

AbstractProcess-induced porosity, defects, and residual stresses lead to mechanical performance degradation in fiber-reinforced composite and other heterogeneous structures. Physical and chemical processes create complex process–material–performance relationships. Predicting porosity and residual stresses in this context requires computationally burdensome forward simulations and obtaining optimal process settings and calibrating properties of new materials requires solving inverse problems with predictions from the forward simulations. In this paper, we parameterized the process–material–performance space and created a dataset based on physics models that are valid for sintering ceramic powders. The dataset was used to train several machine learning models that captured the process–material–performance relationships. The trained ML models were applied in process optimization, calibration of properties for new material systems, and estimating performance for a given process and material. Support vector regression (SVR), convolutional neural networks (CNNs), and a Gaussian mixture model (GMM) called REPAIRS were selected, and their prediction accuracy was determined. While the SVR and CNN models require training several models, we show that the GMM model captures the process–material–performance relationships with a single machine-learned model and partial system completion methods. The paper describes root-mean-square error and mean absolute percentage errors of the inferences from the models on a validation dataset.
Ideal Bi-Based Hybrid Anode Material for Ultrafast Charging of Sodium-Ion Batteries at Extremely Low Temperatures
Authors: Bai Jie , Jia Jian Hui , Wang Yu , Yang Chun Cheng , Jiang Qing 
Published: November 2024

AbstractSodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at − 20 °C or lower. However, the key capability of ultrafast charging at ultralow temperature for SIBs is rarely reported. Herein, a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue, which is synthesized via a high temperature shock method. Such a hybrid shows an unprecedented rate performance (237.9 mAh g−1 at 2 A g−1) at − 60 °C, outperforming all reported SIB anode materials. Coupled with a Na3V2(PO4)3 cathode, the energy density of the full cell can reach to 181.9 Wh kg−1 at − 40 °C. Based on this work, a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.
Outpatient parenteral antimicrobial therapy in pediatrics: the role of antimicrobial stewardship
Authors: Trisno Daniel J. , Puckett Lauren , Jensen Alexandria , Schwenk Hayden T. 
Published: November 2024

Abstract
This study characterized outpatient parenteral antimicrobial therapy (OPAT) orders and associated antimicrobial stewardship program (ASP) pharmacist recommendations made in a freestanding children’s hospital. Recommendations occurred in over 50% of orders, indicating an opportunity for the review of OPAT by ASP pharmacists.
On invariant measures of ‘satellite’ infinitely renormalizable quadratic polynomials
Authors: LEVIN GENADI , PRZYTYCKI FELIKS 
Published: November 2024

Abstract
Let

$f(z)=z^2+c$

be an infinitely renormalizable quadratic polynomial and

$J_\infty $

be the intersection of forward orbits of ‘small’ Julia sets of its simple renormalizations. We prove that if f admits an infinite sequence of satellite renormalizations, then every invariant measure of

$f: J_\infty \to J_\infty $

is supported on the postcritical set and has zero Lyapunov exponent. Coupled with [13], this implies that the Lyapunov exponent of such f at c is equal to zero, which partly answers a question posed by Weixiao Shen.
Hydrodynamic forces on a side-by-side ellipse pair with and without relative motion
Authors: Rhodes Preston , van Rees Wim M. 
Published: November 2024

Motivated by flow interactions in schooling biological swimmers as well as in unmanned underwater vehicle fleets, we investigate the flow past two identical 6 : 1 ellipses using two-dimensional simulations at Reynolds numbers of

$\mathcal {O}(10^3)$

. When both ellipses move at the same velocity, overall drag reductions of 10 %–20 % can be achieved in staggered formations, with the strongest drag reductions occurring at the smallest lateral distances. In side-by-side configurations, the drag on both bodies increases by 10 %–20 %. Lift coefficients are repulsive and up to four times larger than the total drag coefficients. During overtaking manoeuvres, increasing the relative speed of the overtaking ellipse predominantly affects the forces on the overtaken ellipse. The mean drag force on the overtaken ellipse increases with increasing speed difference. Mean lift forces during the overtaking manoeuvre are repulsive for both bodies; as the speed difference increases, the repulsive force increases on the overtaken body and decreases on the overtaking body. Overall, these results highlight that the lateral forces in hydrodynamic interactions between bodies in formation dominate the hydrodynamic interactions. Further, the results indicate that future work is needed to investigate how viscous and three-dimensional effects change the lateral forces between side-by-side submerged bodies.
Waukeshaaspis eatonae n. gen. n. sp.: a specialized dalmanitid (Trilobita) from the Telychian of southeastern Wisconsin
Authors: Randolfe Enrique Alberto , Gass Kenneth C. 
Published: November 2024

Abstract
A new dalmanitid trilobite is described from the early Silurian (Telychian) Waukesha Biota in Wisconsin, USA, best known for its variety of exceptionally preserved arthropods. Waukeshaaspis eatonae new genus new species is the most common trilobite found in the Waukesha Biota, numbering ~200 specimens, allowing a thorough description of the dorsal exoskeleton. This new taxon has a combination of characters unique to the Dalmanitidae, including a distinct embayment on the posterior margin of the pygidium. Embayments are rare for dalmanitids, most species having instead a caudal spine. The lengthening of the genal spines might have served a similar function to that which a caudal spine would have served, allowing the embayment to fulfill a different function, related to keeping an opening when enrolled. The abundance at the preservation site suggests physiological tolerance at the habitation site.
UUID: http://zoobank.org/50a214e3-72f0-4ca2-b8f1-4ad4460bc1d4
Who’s in for no strings: revisiting the determinants of universal basic income support
Authors: Rincón García Leire 
Published: November 2024

Abstract
Universal basic income (UBI) is becoming a prominent alternative to reform the welfare state, yet public support for this policy remains a puzzle. Existing scholarship empirically shows that certain groups like the low-income and left-wing show support, but it remains unclear if this translates to a preference for UBI over alternatives. This paper argues against this assumption: UBI challenges welfare norms and deservingness principles, suggesting people would typically prefer means-tested options. Drawing on a conjoint experiment, this paper empirically shows supportive evidence of the idea that support for a UBI does not translate into an inherent preference for UBI. These findings have widespread implications for both the UBI literature and the politics of welfare reform.
A semi-supervised anomaly detection approach for detecting mechanical failures
Authors: Soete Colin , Rademaker Michaël , Van Hoecke Sofie 
Published: November 2024

Abstract
Predictive maintenance attempts to prevent unscheduled downtime by scheduling maintenance before expected failures and/or breakdowns while maximally optimizing uptime. However, this is a non-trivial problem, which requires sufficient data analytics knowledge and labeled data, either to design supervised fault detection models or to evaluate the performance of unsupervised models. While today most companies collect data by adding sensors to their machinery, the majority of this data is unfortunately not labeled. Moreover, labeling requires expert knowledge and is very cumbersome. To solve this mismatch, we present an architecture that guides experts, only requiring them to label a very small subset of the data compared to today’s standard labeling campaigns that are used when designing predictive maintenance solutions. We use auto-encoders to highlight potential anomalies and clustering approaches to group these anomalies into (potential) failure types. The accompanied dashboard then presents the anomalies to domain experts for labeling. In this way, we enable domain experts to enrich routinely collected machine data with business intelligence via a user-friendly hybrid model, combining auto-encoder models with labeling steps and supervised models. Ultimately, the labeled failure data allows for creating better failure prediction models, which in turn enables more effective predictive maintenance. More specifically, our architecture gets rid of cumbersome labeling tasks, allowing companies to make maximum use of their data and expert knowledge to ultimately increase their profit. Using our methodology, we achieve a labeling gain of 90% at best compared to standard labeling tasks.
Developing a Postpandemic Model for Hybrid Clinical Ethics Rotations in Postgraduate Medical Education
Authors: Kolmes Sara , Dirksen Kevin M. 
Published: November 2024

Abstract
Bioethics education in residency helps trainees achieve many of the Accreditation Council for Graduate Medical Education milestones and gives them resources to respond to bioethical dilemmas. For this purpose, The Providence Center for Health Care Ethics has offered a robust clinical ethics rotation since 2000. The importance of bioethics for residents was highlighted as the COVID-19 pandemic raised significant bioethical concerns and moral distress for residents. This, combined with significant COVID-19-related practical stressors on residents led us to develop a virtual ethics rotation. A virtual rotation allowed residents flexibility as they were called to help respond to the unprecedented demands of a pandemic without compromising high quality education. This virtual rotation prioritized flexibility to support resident wellbeing and ethical analysis of resident experiences. This article describes how this rotation was able to serve residents without overstraining limited bandwidth, and address the loci of resident pandemic distress. As pandemic pressures lessened, The Providence Center for Health Care Ethics transitioned to a hybrid rotation which continues to prioritize resident wellbeing and analysis of ongoing stressors while incorporating in-person elements where they can improve learning. This article provides a description of the rotation in its final form and resident feedback on its effectiveness.
Heterogeneity in 10-year course trajectories of moderate to severe major depressive disorder among veterans
Authors: Panaite V. , Luther S. L. , Finch D. K. , Cohen N. J. , Schultz S. K. , Tsalatsanis A. , Pfeiffer P. N. 
Published: November 2024

Abstract

Aims
Epidemiological studies show that despite the episodic nature, the long-term trajectory of depression can be variable. This study evaluated the heterogeneity of 10-year trajectory of major depressive disorder (MDD) related service utilization and associated clinical characteristics among US Veterans with a first diagnosis after 9/11.

Methods
Using a cohort design, electronic health record data for 293,265 Operation Enduring Freedom and Iraqi Freedom (OEF/OIF) Veterans were extracted to identify those with MDD between 2001 and 2021 with a full preceding year of clinical data and 10 years following the diagnosis. Latent class growth analysis compared clinical characteristics associated with four depression trajectories. Across all Veterans Affairs (VA)hospitals, 25,307 Veterans met our inclusion criteria. Demographic and clinical information from medical records was extracted and used as predictors of depression 10-year trajectories.

Results
Among the study cohort (N = 25,307), 27.7% were characterized by brief contact, 41.7% were later re-entry, 17.6% were persistent contact and 12.9% were prolonged initial contact for depression related services. Compared to Veterans with trajectories showing brief contact, those with protracted treatment (persistent or prolonged initial contact) were more likely to be diagnosed with comorbid posttraumatic stress disorder (PTSD) and with MDD that was moderate to severe or recurrent.

Conclusions
Depression is associated with a range of treatment trajectories. The persistent and prolonged initial contact trajectories may have distinct characteristics and uniquely high resource utilization and disability income. We can anticipate that patients with comorbid PTSD may need longer-term care which has implications for brief models of care.
Sensitivity of Southcentral U.S. Johnsongrass Accessions to Selected Herbicides
Authors: Fleming Jacob , Norsworthy Jason K. , Bagavathiannan Muthukumar , Subramanian Nithya , Barber Tom , Manuchehri Misha , Kumar Vipan , Piveta Leonardo 
Published: November 2024

Abstract
New technologies in grain sorghum allow for the use of multiple acetyl CoA carboxylase- (ACCase) or acetolactate synthase- (ALS) inhibiting herbicides for johnsongrass control. With the growing issue of herbicide resistance, producers need to understand which herbicides will successfully control johnsongrass accessions. To determine the efficacy of herbicides recently registered or ones with potential to become available for use in grain sorghum, johnsongrass seeds were collected from 2017 to 2021 in Arkansas, Kansas, Texas, and Oklahoma and were screened for sensitivity to fluazifop, quizalofop, nicosulfuron, and imazamox. Additionally, glyphosate sensitivity was evaluated because of its use before planting or postharvest. Quizalofop resulted in 100% mortality of all johnsongrass accessions. Of the johnsongrass accessions evaluated, 89% were completely controlled with glyphosate. The ALS inhibitors nicosulfuron and imazamox resulted in 100% mortality of all Oklahoma accessions, but failures occurred on samples from other states. One accession from Kansas, 12 from Texas, and eight from Arkansas were found to have reduced sensitivity to nicosulfuron and imazamox. If producers plan to plant grain sorghum in areas with johnsongrass populations, an ACCase-inhibitor herbicide will most likely provide effective control. Imazamox and nicosulfuron, in conjunction with the appropriate trait, can be utilized in areas with sensitive johnsongrass populations or where other sensitive grass species are present.
Newly Established Bermudagrass Response to Topramezone and Photosystem II-Inhibitor Herbicides
Authors: Negrisoli Raphael M. , Odero D. Calvin 
Published: November 2024

Abstract
Bermudagrass is the most troublesome and difficult-to-control perennial grass weed in Florida sugarcane. Once established, it is only controlled effectively during the sugarcane fallow period using nonselective herbicides and tillage combinations. It is important to evaluate options for selective management of bermudagrass that escape sugarcane fallow period management programs to mitigate its progressive increase as the crop cycle increases from plant cane to ratoon crops. Greenhouse and field studies were conducted in Belle Glade, Florida, from 2017 to 2018 to determine the response of newly established bermudagrass from sprigs with stolons to two or three sequential applications of topramezone (25 and 50 g ha-1) every 14 d and the combinations of topramezone (25 and 50 g ha-1 ) with photosystem II (PS II)-inhibitor herbicides atrazine (2,240 g ha-1), ametryn (440 g ha-1), and metribuzin (2,240 g ha-1). Two or three sequential applications of topramezone with a cumulative total of 75 to 100 g ha-1 provided >93% bermudagrass control 42 d after the first sequential application under greenhouse and field conditions. These treatments had 12% chance of survival 70 d after the first sequential application. There was an additive effect of PS-II inhibitor herbicides on bermudagrass control in mixtures with topramezone. The mixture of topramezone (50 g ha-1) with metribuzin and atrazine provided more than 87% and 92% bermudagrass control under greenhouse and field conditions, respectively, 42 d after treatment. Bermudagrass treated with topramezone (50 g ha-1) mixture with metribuzin had 23% chance of survival 70 d after treatment. The results show good efficacy of sequential topramezone applications every 14 d or mixtures with PS-II inhibitor herbicides atrazine and metribuzin for control of newly established bermudagrass which typically escape control measures during the sugarcane fallow management period.