bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does helicopter transport delay prehospital transfer for STEMI patients in rural areas? Findings from the CRAC France PCI registry
Authors: Hakim Radwan , Revue Eric , Saint Etienne Christophe , Marcollet Pierre , Chassaing Stephan , Decomis Marie Pascale , Yafi Wael , Laure Christophe , Gautier Sandra , Godillon Lucile , Akkoyun-Farinez Julie , Angoulvant Denis , Koning Rene , Motreff Pascal , Grammatico-Guillon Leslie , Rangé Gregoire 
Published: September 2019

Aims:
The aim of this study was to analyse delays in emergency medical system transfer of ST-segment elevation myocardial infarction (STEMI) patients to percutaneous coronary intervention (PCI) centres according to transport modality in a rural French region.

Methods and results:
Data from the prospective multicentre CRAC / France PCI registry were analysed for 1911 STEMI patients: 410 transferred by helicopter and 1501 by ground transport. The primary endpoint was the percentage of transfers with first medical contact to primary percutaneous coronary intervention within the 90 minutes recommended in guidelines. The secondary endpoint was time of first medical contact to primary percutaneous coronary intervention. With helicopter transport, time of first medical contact to primary percutaneous coronary intervention in under 90 minutes was less frequently achieved than with ground transport (9.8% vs. 37.2%; odds ratio 5.49; 95% confidence interval 3.90; 7.73; P&lt;0.0001). Differences were greatest for transfers under 50 km (13.7% vs. 44.7%; P&lt;0.0001) and for primary transfers (22.4% vs. 49.6%; P&lt;0.0001). The median time from first medical contact to primary percutaneous coronary intervention and from symptom onset to primary percutaneous coronary intervention (total ischaemic time) were significantly higher in the helicopter transport group than in the ground transport group (respectively, 137 vs. 103 minutes; P&lt;0.0001 and 261 vs. 195 minutes; P&lt;0.0001). There was no significant difference in inhospital mortality between the helicopter and ground transport groups (6.9% vs. 6.6%; P=0.88).

Conclusions:
Helicopter transport of STEMI patients was five times less effective than ground transport in maintaining the 90-minute first medical contact to primary percutaneous coronary intervention time recommended in guidelines, particularly for transfer distances less than 50 km.
Posterior acetabular uptake on 18F-fluoride positron emission tomography/computed tomography reveals a putative contrecoup region in patients with femoroacetabular impingement
Authors: Oishi Takayuki , Kobayashi Naomi , Choe Hyonmin , Tezuka Taro , Kobayashi Daigo , Higashihira Shota , Inaba Yutaka 
Published: August 2019

Background and purpose: The pathology of the posterior acetabular lesions, so-called “contrecoup regions”, in femorocacetabular impingement (FAI) has not been elucidated fully. 18F-fluoride positron emission tomography/computed tomography (PET/CT) can visualize abnormal uptake caused by impingement. Therefore, we aimed to evaluate posterior acetabular uptake on PET/CT in FAI patients. Patients and methods: Patients with FAI who underwent 18F-fluoride PET/CT between October 2014 and October 2016 were retrospectively evaluated. The maximum standardized uptake value (SUVmax) in the posterior acetabulum was evaluated. The mean SUVmax of FAI with cam morphology (the cam group) was compared with that of FAI with pincer morphology (the pincer group). In addition, the numbers of cases with SUVmax ≥ 6 and SUVmax < 6 in each group were evaluated. The entire study cohort was also grouped according to SUVmax, and the mean α and center edge angles were evaluated. Results: In total, 41 hips were analyzed (34 hips in the cam group and 7 in the pincer group). The mean SUVmax of the cam group (11.2 ± 7.4) was significantly higher than that of the pincer group (4.9 ± 1.9) ( p < 0.01). The incidence of cases with SUVmax ≥ 6 in the cam group was significantly high ( p < 0.01). In the overall cohort, the mean α angle of the SUVmax ≥ 6 group was significantly higher than that of the SUVmax < 6 group ( p < 0.01). Conclusion: Evaluation of posterior acetabular uptake suggests an association between cam morphology and increased posterior acetabular uptake.
Diagnostic imaging in adult non-cystic fibrosis bronchiectasis
Authors: Juliusson Gunnar , Gudmundsson Gunnar 
Published: September 2019

Radiology plays a key role in the diagnosis of bronchiectasis, defined as permanent dilatation of the bronchial lumen. Volumetric thin-section multidetector computed tomography is an excellent noninvasive modality to evaluate bronchiectasis. Bronchiectasis is categorised by morphological appearance. Cylindrical bronchiectasis has a smooth tubular configuration and is the most common form. Varicose bronchiectasis has irregular contours with alternating dilating and contracting lumen. Cystic bronchiectasis is the most severe form and exhibits saccular dilatation of bronchi. Bronchial dilatation is the hallmark of bronchiectasis and is evaluated in relation to the accompanying pulmonary artery. A broncho–arterial ratio exceeding 1:1 should be considered abnormal. Normal bronchi are narrower in diameter the further they are from the lung hila. Lack of normal bronchial tapering over 2 cm in length, distal from an airway bifurcation, is the most sensitive sign of bronchiectasis. Findings commonly associated with bronchiectasis include bronchial wall thickening, mucus plugging and tree-in-bud opacities. Bronchiectasis results from a myriad of conditions, with post-infectious bronchiectasis being the most common. Imaging can sometimes discern the cause of bronchiectasis. However, in most cases it is nonspecific or only suggestive of aetiology. While morphological types are nonspecific, the distribution of abnormality offers clues to aetiology.Key pointsBronchiectasis is a chronic progressive condition with significant disease burden and frequent exacerbations, for which the diagnosis relies on cross-sectional imaging.The major imaging findings include bronchial dilatation, bronchial contour abnormalities and visualisation of the normally invisible peripheral airways.Bronchiectasis is the end result of various conditions, including immunodeficiencies, mucociliary disorders and infections. Imaging is often nonspecific with regard to aetiology but can be suggestive.Distribution of abnormality in the lung offers helpful clues for establishing aetiology.Educational aimsTo review the cross-sectional imaging appearance of bronchiectasis and the common associated findings.To get a sense of how radiology can aid in establishing the aetiology of bronchiectasis.
Robot-assisted unicompartmental knee arthroplasty for patients with isolated medial compartment osteoarthritis is cost-effective
Authors: Clement Nick D. , Deehan David J. , Patton James T. 
Published: August 2019

Aims The primary aim of the study was to perform an analysis to identify the cost per quality-adjusted life-year (QALY) of robot-assisted unicompartmental knee arthroplasty (rUKA) relative to manual total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) for patients with isolated medial compartment osteoarthritis (OA) of the knee. Secondary aims were to assess how case volume and length of hospital stay influenced the relative cost per QALY. Patients and Methods A Markov decision analysis was performed, using known parameters for costs, outcomes, implant survival, and mortality, to assess the cost-effectiveness of rUKA relative to manual TKA and UKA for patients with isolated medial compartment OA of the knee with a mean age of 65 years. The influence of case volume and shorter hospital stay were assessed. Results Using a model with an annual case volume of 100 patients, the cost per QALY of rUKA was £1395 and £1170 relative to TKA and UKA, respectively. The cost per QALY was influenced by case volume: a low-volume centre performing ten cases per year would achieve a cost per QALY of £7170 and £8604 relative to TKA and UKA. For a high-volume centre performing 200 rUKAs per year with a mean two-day length of stay, the cost per QALY would be £648; if performed as day-cases, the cost would be reduced to £364 relative to TKA. For a high-volume centre performing 200 rUKAs per year with a shorter length of stay of one day relative to manual UKA, the cost per QALY would be £574. Conclusion rUKA is a cost-effective alternative to manual TKA and UKA for patients with isolated medial compartment OA of the knee. The cost per QALY of rUKA decreased with reducing length of hospital stay and with increasing case volume, compared with TKA and UKA. Cite this article: Bone Joint J 2019;101-B:1063–1070.
The effect of patient institutional transfer during the interstage period of two-stage treatment for prosthetic knee infection
Authors: Garceau Simon , Warschawski Yaniv , Dahduli Omar , Alshaygy Ibrahim , Wolfstadt Jesse , Backstein David 
Published: August 2019

Aims The aim of this study was to assess the effects of transferring patients to a specialized arthroplasty centre between the first and second stages (interstage) of prosthetic joint infection (PJI) of the knee. Patients and Methods A search of our institutional database was performed to identify patients having undergone two-stage revision total knee arthroplasty (TKA) for PJI. Two cohorts were created: continuous care (CC) and transferred care (TC). Baseline characteristics and outcomes were collected and compared between cohorts. Results A total of 137 patients were identified: 105 in the CC cohort (56 men, 49 women; mean age 67.9) and 32 in the TC cohort (17 men, 15 women; mean age 67.8 years). PJI organism virulence was greater in the CC cohort (36.2% vs 15.6%; p = 0.030). TC patients had a higher rate of persisting or recurrent infection (53.6% vs 13.4%; p < 0.001), soft-tissue complications (31.3 vs 14.3%; p = 0.030), and reduced requirement for porous metal augments (78.1% vs 94.3%; p = 0.006). Repeat first stage debridement after transfer led to greater need for plastic surgical procedures (58.3% vs 0.0%; p < 0.001). Conclusion Patient transfer during the interstage of treatment for infected TKA leads to poorer outcomes compared with patients receiving all their treatment at a specialized arthroplasty centre. Cite this article: Bone Joint J 2019;101-B:1087–1092.
Prognostic impact of intra- and postoperative management of dural tear on postoperative complications in primary degenerative lumbar diseases
Authors: Takenaka Shota , Makino Takahiro , Sakai Yusuke , Kashii Masafumi , Iwasaki Motoki , Yoshikawa Hideki , Kaito Takashi 
Published: August 2019

Aims The aim of this study was to explore risk factors for complications associated with dural tear (DT), including the types of DT, and the intra- and postoperative management of DT. Patients and Methods Between 2012 and 2017, 12 171 patients with degenerative lumbar diseases underwent primary lumbar spine surgery. We investigated five categories of potential predictors: patient factors (sex, age, body mass index, and primary disease), surgical factors (surgical procedures, operative time, and estimated blood loss), types of DT (inaccessible for suturing/clipping and the presence of cauda equina/nerve root herniation), repair techniques (suturing, clipping, fibrin glue, polyethylene glycol (PEG) hydrogel, and polyglycolic acid sheet), and postoperative management (drainage duration). Postoperative complications were evaluated in terms of dural leak, prolonged bed rest, headache, nausea/vomiting, delayed wound healing, postoperative neurological deficit, surgical site infection (SSI), and reoperation for DT. We performed multivariable regression analyses to evaluate the predictors of postoperative complications associated with DT. Results In total, 429/12 171 patients (3.5%) had a DT. Multivariable analysis revealed that PEG hydrogel significantly reduced the incidence of dural leak and prolonged bed rest, and that patients treated with sealants (fibrin glue and PEG hydrogel) significantly less frequently suffered from headache. A longer drainage duration significantly increased the incidence of headache, nausea/vomiting, and delayed wound healing. Headache and nausea/vomiting were significantly more prevalent in younger female patients. Postoperative neurological deficit and reoperation for DT significantly depended on the presence of cauda equina/nerve root herniation. A longer operative time was the sole independent risk factor for SSI and was also a risk factor for dural leak, prolonged bed rest, and nausea/vomiting. Conclusion Sealants, particularly PEG hydrogel, may be useful in reducing symptoms related to cerebrospinal fluid leakage, whereas prolonged drainage may be unnecessary. Younger female patients should be carefully treated when DT occurs. Cite this article: Bone Joint J 2019;101-B:1115–1121.
Trends in digitalization of intralogistics and the critical success factors of its implementation
Authors: Winkler Hannes , Zinsmeister Lena 
Published: September 2019

Goal: Digitalization is a maior trend in intralogistics, both for academia and for the industry. This paper gives an overview on current intralogistic trends, the critical success factors of digitalization projects in intralogistics and the results of an online survey regarding these trends and success factors.
Design / Methodology / Approach: Literature reviews for both intralogistic trends and the success factors of the implementation were validated using an online survey with 105 intralogistic professionals, both from academia and industry.
Results: Both trends and success factors could be validated and brought into a ranking regarding their importance.
Limitations of the investigation: The online survey had a limited number of respondends and, even though all trends were provided with a short explanation, different interpretations or understandings of trends and success factors might have been present. Moreover, some trends and success factors have a certain overlap and the differences are not always clear.
Practical implications: The survey and the description of intralogistic trends and success factors allow practitioners to better understand, structure and prioritize their implementation projects and possibly to increase their success rate.
Originality / Value: There are several studies on general logistic trends and a few studies regarding success factors for digitalization, mostly in the field of ERP implementation. The presented research and online survey are a contribution to the specific field of trends and success factors in digitalization of intralogistics.
Sustainable practices and the relationship with suppliers in SSCM: a case study in wholesale
Authors: Silva Rosa Arthur Antonio , Abdala Etienne Cardoso , Cezarino Luciana Oranges 
Published: September 2019

Goal: The present study aimed to analyze how sustainability of suppliers affect the sustainability of a wholesaler-distributor located in the city of Uberlândia, Minas Gerais, Brazil.
Design / Methodology / Approach: A qualitative approach was chosen using the case study and content analysis as methodologies and the main instrument for data collection was the interview.
Results: The results suggest a direct relationship between the sustainability of the focal company and that of supply chain members, so that the alignment of Triple Botton Line (TBL) practices along the chain is essential to emphasize the effects of these practices and for the company to be considered sustainable, as indicated by sustainable supply chain concepts.
Limitations of the investigation: The main limitation was the use of a single case study, which does not allow the generalization of results to other companies.
Practical implications: It was possible to analyze the relationship between the sustainable practices of suppliers and the focal company to confirm the need to align sustainable practices throughout the supply chain. The results suggest that companies could improve their performance in environmental, social and economic terms if they observe and evaluate the sustainability of their suppliers, reducing environmental risks and future losses.
Originality / Value: In terms of literature, this is a topic that has not been explored yet in terms of the applicability of sustainability in the supply chain, especially in practical issues in the wholesale sector.
Digital transformation technologies as an enabler for sustainable logistics and supply chain processes – an exploratory framework
Authors: Junge Anna Lisa 
Published: September 2019

Goal: The aim is to present a literature review for identifying digital transformation technologies (DTT) for manufacturing and pointing out their capabilities and applications. Furthermore, the paper lays out an exploratory framework to depict the impact scope of the cases on logistics and supply chain management (L&SCM) processes.
Design / Methodology / Approach: The identification of relevant DTTs and their capabilities is based on a systematic literature review. The exploratory framework builds upon Industry 4.0 concepts and frameworks as well as the conditions for sustainable digital artefacts. It is then related to cases found in the systematic literature review.
Results: The results indicate that the DTT auto identification, additive manufacturing, and cloud technology lead to improvements concerning transparency efficiency, optimizing distribution distances and logistics resources in networks. The framework presents an avenue for assessing the impact scope and potentials of implementing DTT.
Limitations of the investigation: The literature base limits the findings since it is built upon two databases and is restricted to articles published in English. The theoretically deduced framework accounts for the dimensions technologies, the SCOR model and RAMI architecture. The illustration is simplified but can be detailed according to the needs. It is not tested based on case studies and should therefore be applied in practice to further develop it.
Practical implications: Practitioners gain insight into how to anchor potential use cases for more sustainable L&SCM processes in the framework.
Originality / Value: This paper is the first to relate the capabilities of DTT to more sustainable L&SCM processes in manufacturing by means of a systematic literature review and link the findings to an exploratory framework.
A new mechanism of the protamine-dependent hypotension after cardiopulmonary bypass and the role of calcium
Authors: Aydin Suna , Aydin Suleyman 
Published: August 2019

Heparin and protamine are two indispensable agents of cardiopulmonary bypass surgery with effects on the cardiovascular and hematological system. Heparin is used as an anticoagulant in open heart surgery; whereas protamine is used to neutralize heparin effects when surgery is terminated. Protamine is given in order to neutralize heparin effects after cardiopulmonary bypass surgery and it causes hypotension in patients. However, the mechanism of this side effect is not clearly known. Current mechanism is that hypotension occurs after the administration of protamine due to the conformational change in the calcium channels or anaphylactoid thromboxane release or serum ionized calcium levels. The present study was to explain how protamine causes hypotension in evidence-based medicine indexed in PubMed and Web of Science. In addition to above mechanisms, possibly the infused protamine binds heparin and causes the coagulation cascade to activate heparin-AT complex on thrombin beside activating FXIa, FXa and FIXa and causing the re-use of Ca2+. The re-use of Ca2+ at the coagulation cascade initiates an anion gap and it is assumed that hypotension develops because of the Ca2+ deficiency. Ca2+ ions are trapped in the thrombus by the resumption of thrombus formation. Ca2+ ions trapped in the thrombus cannot be used, so that Ca2+ ion deficit will develop in circulation and hypotension occurs due to the insufficiency of Ca2+ ions. The administration of Ca2+ ions together with the protamine might help to eliminate the side effect of the protamine (hypotension) while neutralizing heparin after open heart surgery in light of the information provided in the literature.
Adiposity and attained height in adolescents: a longitudinal analysis from the LabMed Physical Activity Study
Authors: Rosário Rafaela , Agostinis-Sobrinho Cesar , Lopes Luís , Moreira Pedro , Padrão Patrícia , Oliveira André , Moreira Carla , Póvoas Susana , Mota Jorge , Santos Rute 
Published: September 2019

Abstract

Background
To investigate the associations between adiposity and attained height over a 2-year period in healthy adolescents.

Methods
One thousand and seventeen adolescents aged 12–18 years participated in this cohort study; 893 (87.8%) were reevaluated 1 year later (T2) and 734 (72.2%) subjects 2 years later (T3). Body fat and anthropometry were measured according to standardized procedures. Socioeconomic status, pubertal stage and lifestyles determinants were gathered and used as confounders. Prospective associations between adiposity and height were examined using generalized linear models.

Results
Greater adiposity at T1 was significantly associated with a lower attained height over time, when adjusting for confounders, which varied between 0.03 and 1 cm in T2 and 0.1 and 1 cm in T3.

Conclusions
Excess of adiposity in early adolescence may exert an effect on attained height in late adolescence. This study supports future lifestyles intervention studies aiming at preventing overweight and obesity and improving attained height.
Risk index to monitor an anaerobic digester using a dynamic model based on dilution rate, temperature, and pH
Authors: Alzate-Ibañez Angélica M. , Ocampo-Martinez Carlos , Alzate Carlos A. Cardona , Montoya Víctor M. Trejos 
Published: September 2019

AbstractIn this work, a risk index to monitor an anaerobic digestion process is established. The index is derived from the dynamical analysis of the system and it is composed by two conditions ensuring an optimum operating conditions inside bioreactor. The analysis is performed using bifurcation theory in order to study the effects of dilution rate, temperature and pH parameters at behavior system. For these purpose an extended version of the mathematical model proposed by Bernard [1] involving the dependence of growth kinetics on temperature and pH is used. The analysis shows both microbial growth and the performance of the bioprocess, when is highly affected by these parameters, indeed the washout condition occurs by combining a fold bifurcation and a transcritical bifurcation. From bifurcation diagrams both safety and optimal operation regions of the bioreactor are defined. Consequently, based on two conditions of stability a risk index to monitor the bioprocess on-line is proposed. The index is evaluated via numerical simulations allowing to detect system destabilization. The results obtained in this work may provide a useful methodology to monitor an anaerobic process and to guarantee the optimal performance of the bioreactor given that the model is sufficiently accurate.