bluuebunny/crossref_metadata_2025_split huggingface dataset:
Weekly Docetaxel, Cisplatin, and Cetuximab in Palliative Treatment of Patients with Squamous Cell Carcinoma of the Head and Neck
Authors: Trieu Vanessa , Pinto Harlan , Riess Jonathan W. , Lira Ruth , Luciano Richard , Coty Jessie , Boothroyd Derek , Colevas A. Dimitrios 
Published: March 2018

Abstract

Lessons Learned
Chemotherapy for recurrent, metastatic squamous cell carcinoma of the head and neck need not be known for extreme toxicity. The weekly regimen studied here has been demonstrated to be tolerable and effective.

Background
The objective of this study was to establish the response rate, progression-free survival (PFS) and overall survival (OS), and safety profile of weekly docetaxel, platinum, and cetuximab (TPC) in patients with relapsed or metastatic squamous cell carcinoma of the head and neck (SCCHN).

Materials and Methods
Twenty-nine patients with metastatic or recurrent SCCHN with an Eastern Cooperative Oncology Group (ECOG) performance status &lt;3 were enrolled in an institutional review board-approved phase II trial. This study permitted prior chemoradiation, radiation, and/or surgery, provided that 3 months had elapsed since the end of the potentially curative treatment. Patients received cisplatin 30 mg/m2 or carboplatin area under the curve (AUC) 2, docetaxel 30 mg/m2, and cetuximab 250 mg/m2 weekly for 3 weeks, followed by a break during the fourth week, for a 28-day cycle. Planned intrapatient dose modifications were based on individual toxicity.

Results
Twenty-seven patients received TPC and were evaluable for response and toxicity. Rates of complete response (CR), partial response (PR), and confirmed PR were 3%, 52%, and 30%, respectively. The overall objective response rate was 56%. Estimated median PFS and OS were 4.8 and 14.7 months, respectively. The rates of grade 3 and 4 worst-grade adverse events (AEs) per patient were 85% and 7%, respectively. Dose density through cycle 4 was preserved for all patients; however, treatment beyond cycle 6 with the TPC regimen proved unfeasible.

Conclusion
Weekly docetaxel, cisplatin, and cetuximab is an effective regimen for patients with metastatic or recurrent SCCHN. Response rates, PFS, and OS compare favorably with other combination chemotherapy treatments. Grade 4 toxicity rates observed in this study were substantially lower than those described with regimens using less frequent, higher-dose chemotherapy schedules.
Examination of International Pisa Test Results with Artificial Neural Networks and Regression Methods
Authors: Benzer Semra , Benzer Recep 
Published: March 2018

Abstract It
is approved that artificial neural networks are considerably effective in
analyzing flows in which traditional methods and statics are inadequate to
solve. In this article, we use a two-layer feedforward network with tan-sigmoid
transmission function in input and output layers with PISA of Turkey and
Organisation for Economic Cooperation and Development (OECD) science level
values. OECD Programme for International Student Assessment (PISA) surveys
reading, mathematical and scientific literacy levels every three years. The
PISA assessment works on young people’s ability to apply their knowledge and
skills to real-life problems and situations rather than on how much
curriculum-based knowledge they have. Assessments are made on three core fields
reading literacy, mathematical literacy and scientific literacy. The conclusion
is that PISA is an important global benchmarking tool, but that bureaucrats and
the media need to use the rich data that have been collected together
with information about
their academic performance.
According to statistical evaluations, regression value of ANN was higher than
value of regression methods.Keywords: PISA, Artificial Neural Networks, Regression
Methods.
Cytotoxic and Genotoxic Effects of Aqueous Extracts of Rosmarinus officinalis L., Lavandula stoechas L. and Tilia cordata Mill. on in vitro Human Peripheral Blood Lymphocytes
Authors: Aşkın Çelik Tülay , Aslantürk Özlem Sultan 
Published: March 2018

The aim of this study was to investigation of in
vitro cytotoxic and genotoxic effects of infusion and decoction aqueous
extracts obtained from Rosmarinus officinalis, Lavandula stoechas
L. and Tilia cordata Mill. on human peripheral blood lymphocytes. For this purpose, lymphocytes taken from 3
females, were treated with aqueous extracts of R. officinalis (1.5 and 3
mg/ml),&nbsp; L. stoechas (0,4 and 1,2
mg/ml) and T. cordata (1 mg/ml and 3 mg/ml) for 48 hours. PBS was used
as negative control and Mitomycin C (MMC) (0,25 μg/ml) was used as positive
control in experiments. Cytotoxic effect of extracts on lymphocytes was
determined by calculating mitotic index. Also, chromosome aberrations
micronucleus formations were determined.&nbsp;

All extracts considerably decreased the
cell division in lymphocytes depending on the increased concentration in
comparison with control groups (p&lt;0,01). Also cells in metaphase decreased.
Thus, no chromosomal aberration was observed in lymphocytes. However, extract
treatments induced the formation of micronucleus in lymphocytes when compared
to control groups (p&lt;0,01). 3 mg/ml decoction extracts of L. stoechas and
T. cordata showed the highest cytotoxic effect on lymphocytes, and the
highest genotoxic effect appeared after 48 h treatment with 1.2 mg/ml decoction
extract of L. stoechas.&nbsp;
Application of Spectroscopic Methods for Analysis of Ni-Based Alloys (Ni% ≥70)
Authors: Aygün Zeynep 
Published: March 2018

In this paper, we investigate the structural and magnetic properties of
Ni based alloys which are in the form of NixFeyMoz
(x = 0.80; y = 0.15; z = 0.05), NixCryFez (x =
0.70; y = 0.20; z = 0.10), and NixCryAlzCut (x = 0.75; y = 0.20; z =
0.025; t = 0.025) and are prepared by heating the pellet formed samples at high
temperature. For this purpose, electron paramagnetic resonance experiment is
performed for analysis of paramagnetic centers of these compositions to see the
behaviours of alloys in an external magnetic field. g values are calculated
from electron paramagnetic resonance spectra recorded at room temperature.
Structural features of NixFeyMoz,
NixCryFez and NixCryAlzCut
alloys are observed by x-ray diffraction technique. Line positions and line
intensities are discussed by the help of x-ray diffraction spectra recorded at
room temperature. In order to understand the surface morphology of samples,
scanning electron microscopy; for the elemental compositions of the alloys
energy dispersive spectrosopy experiments are carried out at room temperature.
MODEL PENENTUAN SISTEM JARINGAN AIR BERSIH UNTUK MITIGASI BENCANA KEBAKARAN PERKOTAAN DENGAN SISTEM PAKAR BERBASIS SISTEM INFORMASI GEOGRAFIS
Authors: TARIDALA SABRILLAH 
Published: March 2018

<p><em>Kendari City is an urban area with the smallest area and the densest population in Southeast Sulawesi Province. Fire disaster in the city of Kendari often occurs and has caused considerable losses, to claim casualties. This study aims to build a model of determining clean water network system for fire disaster mitigation in Kendari City, using Expert System approach based on Geographic Information System (GIS). The results showed that the clean water network for firefighting in Kendari City is classified into four categories, namely Very Suitable for the development of the network as much as 267 grids, Suitable for the development of 5,819 grids, Sufficient Suitable for network development of 38,493 grids, and Not Recommended for network development clean water for urban firefighting, as many as 63,257 grids. Suitable clean water network for fire disaster mitigation in Kendari City is an area close to potential water sources for outages, located in urban areas with high and very high fire risk levels and is in medium to densely populated areas, whereas urban areas is not recommended for the development of clean water network is the area prone to flood and landslide disaster, with hilly and mountainous morphology and this area is not a residential area. </em><br /> <br /><em><strong>Keywords</strong> : Expert System, GIS, Model, urban fire, water supply</em></p><p><em>Kota Kendari merupakan suatu kawasan perkotaan dengan luas wilayah terkecil dan jumlah penduduk terpadat di Provinsi Sulawesi Tenggara. Bencana kebakaran di Kota Kendari sering terjadi dan telah menimbulkan kerugian yang cukup banyak, hingga menelan korban jiwa. Penelitian ini bertujuan untuk membangun model penentuan sistem jaringan air bersih untuk mitigasi bencana kebakaran di Kota Kendari, dengan menggunakan pendekatan Sistem Pakar (Expert System) berbasis Sistem Informasi Geografis (SIG). Hasil penelitian menunjukkan bahwa jaringan air bersih untuk pemadaman kebakaran di Kota Kendari terklasifikasi dalam empat kategori, yaitu Sangat Sesuai untuk pengembangan jaringan sebanyak 267 grid, Sesuai untuk pengembangan sebanyak 5.819 grid, Cukup Sesuai untuk pengembangan jaringan sebanyak 38.493 grid, dan Tidak Dianjurkan bagi pengembangan jaringan air bersih untuk pemadaman kebakaran perkotaan, sebanyak 63.257 grid. Jaringan air bersih yang Sangat Sesuai untuk mitigasi bencana kebakaran di Kota Kendari merupakan kawasan yang dekat dengan sumber air potensial untuk pemadaman, berada pada kawasan perkotaan dengan tingkat risiko kebakaran tinggi dan sangat tinggi serta berada pada daerah hunian yang sedang hingga padat, sedangkan kawasan perkotaan yang tidak dianjurkan bagi pengembangan jaringan air bersih merupakan daerah kawasan rawan bencana banjir dan longsor, dengan morfologi berbukit dan bergunung dan kawasan ini bukan merupakan daerah hunian. </em></p><p><em><strong>Kata kunci</strong> : Sistem Pakar, SIG, model, kebakaran perkotaan, air bersih</em></p>
ANALISIS DIAGNOSA PENYAKIT TANAMAN PADI DENGAN METODE FUZZY INFERENCE SYSTEM DAN CERTAINTY FACTOR
Authors: Muliadi Muliadi 
Published: March 2018

<p><em>Rice plants are now many been developed in the swamp land. One of the problems is disease of rice is a risk that must be faced and counted in rice cultivation to increase production as expected. The purpose of this research is an analysis of rice disease diagnosis that grows in wetlands by applying the method of Fuzzy Inference System and Certainty Factor. Fuzzy Inference System used in this system is fuzzy Tsukamoto used to obtain the value measure of belief (MB) and a measure of disbelief (MD) symptoms of the disease. And the certainty factor (CF) for the assessment of each disease. The result that obtained is the analysis succeeded in giving a diagnosis of disease in rice of symptoms that attack the rice.</em></p><p><em><strong>Keywords</strong>:<strong> </strong>Rice Plants, Diagnosis, Fuzzy Inference System Tsukamoto, Certainty Factor.</em></p><p><em>Tanaman padi sekarang banyak dikembangkan di lahan rawa. Salah satu masalahnya adalah penyakit padi, yang merupakan resiko yang harus dihadapi dan diperhitungkan dalam budidaya padi untuk meningkatkan produksi yang sesuai dengan harapan. Tujuan penelitian ini adalah membuat analisis diagnosa penyakit padi yang tumbuh di lahan rawa dengan menerapkan metode Fuzzy Inference System dan Certainty Factor. Fuzzy Inference System yang digunakan dalam sistem ini adalah Fuzzy Tsukamoto yang digunakan untuk memperoleh nilai measure of belief (MB) dan measure of disbelief (MD) gejala terhadap suatu penyakit. Sedangkan certainty factor (CF) untuk pemberian nilai masing-masing penyakit. Hasil yang didapatkan yaitu analisis ini berhasil memberikan diagnosa penyakit yang padi dari gejala-gejala yang menyerang padi tersebut.</em></p><em><strong>Kata kunci</strong>:<strong> </strong>Tanaman Padi, Diagnosa, Fuzzy Inference System Tsukamoto, Certainty Factor.</em>
Study of the variation of haloacetic acids in a simulated water distribution network
Authors: Mompremier Rojacques , Fuentes Mariles Óscar Arturo , Becerril Bravo José Elías , Ghebremichael Kebreab 
Published: March 2018

Abstract
This paper presents the analysis of the variation of haloacetic acids (HAAs) for different pipe materials in a distribution system. The work involved an experimental study on a simulated distribution system assembled in the Hydraulic Laboratory of the Engineering Institute at the National Autonomous University of Mexico (Instituto de Ingeniería UNAM). Two different scenarios were investigated based on different pipe materials, variation of temperature and initial chlorine concentrations (4.0 and 4.5 mg/L). Feed water with varying amounts of organic content was dosed with varying amounts of chlorine concentration. Water samples were collected from different locations in the distribution system and analyzed for physicochemical properties and HAAs determination. The results of this research demonstrated that the concentration of HAAs in the different segments of the distribution systems varied depending on pipe material, initial chlorine concentration, pH, residence time and the presence of natural organic matter.
ANALISIS HUBUNGAN INTERNAL CORPORATE GOVERNANCE DENGAN THE USE OF IPO OVER-FINANCING
Authors: Edi Edi , Wahyuningrum Enny Aprilliyani 
Published: March 2018

<p><em>The purpose of this study is to analyze the benefits of the accounting information system for financial performance, performance management and organizational performance at Rural Banks in Batam. The dependent variables of this research are financial performance, management performance, and organizational performance. Independent variable of this research is accounting information system. The object of this research use purposive sampling method to BPR registered in Bank Indonesia which is position of Finance and Accounting Manager, Operational Manager and Branch Manager. This study uses multiple linear regression to analyze the effect of the independent variable to the dependent variable. The results obtained that the accounting information system has a significant influence on financial performance, performance management and organizational performance.</em></p><p> </p>
Retinopathy and Mortality
Authors: Frith Emily , Loprinzi Paul D. 
Published: March 2018

Objective.
We evaluated the specific association between retinopathy and all-cause mortality among a national sample of the broader U.S. adult population.

Methods.
Data from the 2005–2008 National Health and Nutrition Examination Survey were used to identify 4,777 adults with complete data regarding screening for nonproliferative retinopathy using Early Treatment Diabetic Retinopathy Study grading criteria, as well as objective retinal imaging assessments using the Canon Non-Mydriatic Retinal Camera CR6-45NM. Participants were not included if they had been diagnosed with coronary artery disease, congestive heart failure, heart attack, or stroke at the baseline assessment.

Results.
Both mild and moderate/severe retinopathy were associated with increased all-cause mortality risk in unadjusted and adjusted models. In the adjusted model, and when compared to those with no retinopathy, those with mild and moderate/severe retinopathy, respectively, had 81% (hazard ratio [HR] 1.81, 95% CI 1.29–2.55) and 314% (HR 4.14, 95% CI 1.77–9.69) increased risks of all-cause mortality.

Conclusion.
In this nationally representative sample of adults, those with mild or moderate/severe retinopathy were at increased risk of all-cause mortality.
PENARAPAN PRINSIP SYARIAH PADA AKAD RAHN DI LEMBAGA PEGADAIAN SYARIAH
Authors: Surahman Maman , Adam Panji 
Published: March 2018

Gadai sebagai salah satu kategori dari perjanjian utang-piutang, untuk suatu kepercayaan dari kreditur, maka debitur menggadaikan barangnya sebagai jaminan terhadap utangnya itu. Barang jaminan tetap milik orang yang menggadaikan, namun dikuasai oleh penerma gadai. Mekanisme teknis gadai syariah, maka secara teknis operasional dapat dilakukan oleh suatu lembaga keungan syariah, yaitu pegadaian syariah, baik sebagai lembaga swasta maupun pemerintah. Dalam hal ini penulis bermaksud untuk melakukan analisis penerapan konsep dan prinsip-prinsip syariah yang teraplikasikan pada akad gadai di lembaga pegadaian syariah. Tujuan penelitian ini adalah untuk: pertama, untuk mengetahui konsep gadai dalam literatur fikih klasik; kedua, untuk mengetahui penerapan prinsip syariah pada akad rahn di lembaga pegadaian sayriah. Metode pendekatan yang digunakan dalam penelitian ini adalah yuridis normatif dengan sifat penelitiandeskriptif analisis. Jenis data yang digunakan dalam penelitian ini adalah jenis data primer dan sekunder. Penelitian ini digolongkan kepada jenis penelitian kualitiatif.Hasil penelitian menyimpulkan bahwa, pertama, konsep gadai dalam literatur fikih klasik dinamai dengan istilah rahn, landasan yuridis kebasahan transkasi/akad gadai dalam Islam terdapat dalam al-Quran surat al-Baqarah: 283, yang secara eksplisit menerangkan hukum gadai, selain terdapat di dalam al-Quran landasan yuridis keabsakan akad gadai/rahn terdapat di dalam beberapa hadis Nabawi serta konsensu/ijma’ para ulama tenteng hal tersebut; kedua, prinisp-prinsip syariah di diterapkan dalam sistem pegadaian syariah ada 3 (tiga) prinsip, yaitu: prinsip tauhid, prinsip tolong-menolong (ta’awun) dan prinsip bisnis (tijariah).
THE CHARACTER EDUCATION VALUES IN QUR’ANIC VERSES
Authors: Budihardjo Budihardjo 
Published: March 2018

Character education is one of the main goals of education. Character education is important due to the common believe that there is the degeneration of ethic and moral of the learners, and also due the rise of juvenile delinquency. Then, character education comes to recover it. Character education can be integrated in various aspects, such as in study al-Qur’ān. The integration between character education and the interpretation of al-Qur’an will make new insight of character education. Moreover, it will be strengthened by the words of Allah. This particular research is intended to reveal whether studies about character education in al-Qur’an will provide a particular kind of character education based on Qur’anic verses, and whether there is any relevance between character education as presented in Qur’anic verses with those presented in curriculum 2013?. To answer these questions, the researcher used descriptive comparative approach, library research as the kind of research, and the use of documentary for collecting the data. This study shows that there are some character education as presented in Qur’anic verses and that there is a relevance between character education values in curriculum 2013 and character education in Qur’anic verses. From the relevance, it is concluded that the character education as presented in Qur’anic verses suggest similar goals as the character education value in curriculum 2013. Pendidikan karakter merupakan salah satu tujuan utama dari pendidikan itu sendiri. Pendidikan karakter sangat penting diajarkan kepada peserta didik lantaran adanya kepercayaan di kalangan masyarakat bahwa dewasa ini telah terjadi degradasi moral dan kenakalan pada peserta didik. Sehingga hadirnya pendidikan karakter dirasa sangat penting untuk memulihkan problem di atas. Apalagi, jika pendidikan karakter itu diintegrasikan dengan nilai-nilai pendidikan yang ada dalam studi al-Qur'an. Untuk itu penelitian ini dimaksudkan untuk mengungkapkan bagaimana studi tentang pendidikan karakter jika dikaitkan dalam perspektif al-Qur'an?, dan apakah ada relevansi antara pendidikan karakter seperti yang disajikan dalam ayat-ayat al-Qur’an dengan yang disajikan dalam kurikulum 2013?. Untuk menjawab pertanyaan ini, peneliti menggunakan pendekatan komparatif deskriptif, penelitian kepustakaan sebagai jenis penelitian, dan penggunaan dokumenter untuk mengumpulkan data. Studi ini menunjukkan bahwa ada beberapa pendidikan karakter seperti yang disajikan dalam ayat-ayat al-Quran, dan ditemukan ada relevansi antara nilai pendidikan karakter dalam kurikulum 2013 dan pendidikan karakter dalam ayat-ayat al-Qur’an. Begitu juga ditemukan bahwa nilai-nilai pendidikan karakter sebagaimana yang terdapat dalam ayat-ayat al-Qur’an, ternyata selaras dengan nilai-nilai pendidikan karakter yang ada dalam kurikulum 2013.
HIPERPLASIA EPITELIAL FOCAL EN ESCOLARES SHUAR TAISHA– ECUADOR 2016
Authors: Corral Peñafiel David Francisco 
Published: March 2018

OBJETIVO: Revelar los posibles desencadenantes en la enfermedad de la Hiperplasia Epitelial Focal (HEF).MATERIALESY MÉTODOS: El presente es un estudio longitudinal, observacional descriptivo, los datos se obtuvieron en la parroquiaTaisha, en la comunidad San José en los meses de junio a septiembre del 2016. La población fue de 210 estudiantes.RESULTADOS: El estudio nos indicó que las condiciones de vida precoces presentan una mayor prevalencia con estapatología. CONCLUSIONES: Las condiciones en las que viven los estudiantes en su comunidad representa un posibledesencadenante para que se prolifere la enfermedad.
Infecciones urinarias del Niño
Authors: Flórez Luz Marina 
Published: March 2018

Centrándose en los estudios biomoleculares realizados última década, los médicos de hoy en día tienen una conocimientos relativos a las infecciones urinarias más amplias: etiología, factores virulentos causadas por microorganismos, las manifestaciones clínicas, la epidemiología y la frecuencia, patogenia, inicial diagnóstico, imagenología, tratamiento, control y prevención. los recientes avances en laboratorio técnicas han hecho posible conseguir una precisión de diagnóstico superior; lo que ayudóla disminución de sus fracasos. El tratamiento se centra en un tratamiento inicial en general, antimicrobiano Las drogas tales Trimetoprin sulfa-40, nitrofurantoína, cefalosporinas 2ª y 3ª generaciones y un control de seguimiento.
Neurociencia y Psicología
Authors: Delgado Reyes Andres Camilo 
Published: March 2018

El presente artículo de revisión tiene como objetivo resaltar la importancia de la Neurociencia y sus diversas disciplinas en el abordaje del ser humano y sus múltiples expresiones conductuales como objeto de estudio, encontrándose en este con la Psicología, ciencia con la que converge en diferentes puntos, los cuales les han permitido la integralidad y complementariedad, viéndose esto plasmado en la presente revisión teórica mediante las diferentes ramas de la Neurociencia en donde la Psicología está presente. Para esto se utilizó una metodología de revisión teórica y documental de diferentes libros y artículos relacionados con la temática, tanto resultados de investigación, como postulados conceptuales de autores reconocidos para este tópico, para posteriormente realizar correlaciones y análisis de los mismos, los cuales permitieran tener un abordaje mucho más completo y así cumplir con el objetivo inicial, obteniendo como conclusión general que la Neurociencia aporta o influye en las esferas teórico, prácticas y sociales de la Psicología, permitiendo que esta última consolide sus diferentes procesos y actuaciones, contando con un sustento biológico de su objeto de estudio.
Use of enzyme preparations for improvement of the flour baking properties
Authors: Zhygunov Dmytro , Mardar Maryna , Kovalyova Vassilina 
Published: March 2018

The main reason for the wheat flour poor quality is a deviation in the enzymatic complex and the biopolymers state due to poor agricultural and technical conditions, pest damage to grain stocks, unfavorable storage conditions. The use of various bakery improvements allows to make the technological process and the quality of bread better.The article presents research on the stabilization of the quality of bakery flour with low amylolytic activity (PE - 426 s) and strong gluten (the quality of gluten on the DIG (deformation index of gluten) device is 40 conditional units. Enzyme preparations with amylase and hemicellulase activity and sulfur-containing amino acid cysteine were used as improvers. The effect of each improver on the baking properties of the flour was determined by the results of the laboratory baking test. Using a complex of these baking improvers makes it possible to increase the efficiency of each component due to the synergy of their action. The complex of improvers in medium dosages showed best results of bread quality, organoleptic and physical parameters of bread improved, the specific volume of bread having increased from 2.4 to 4.3 cm3/g, i.е. in 1.8 times.