bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of tyrosinase inhibition by some 1,2,4 triazole derivative compounds: in vitro and in silico mechanisms
Authors: Ayazoglu Demir Elif , Colak Ahmet , Kalfa Aylin , Yasar Ahmet , Bekircan Olcay , Yildirim Akatin Melike 
Published: December 2018

Abstract

Background
Tyrosinase plays a central role in the biosynthesis pathway of melanin pigment. Melanin protects human skin against radiation and its unusual levels cause some skin disorders such as pregnancy scar, oldness spots and melanoma. Tyrosinase has also been linked to Parkinson’s and other neurodegenerative diseases. In addition, melanin plays a critical role as a defense molecule for insects during wound healing and is important for their life. Therefore, determination of inhibitor molecules for tyrosinase has a promising potential for therapies of some diseases and is an alternative method for keeping insects under control.

Material and methods
In this study, 1-hepthyl-3-(4-methoxybenzyl)-4H-1,2,4-triazole-5-one derivative (A6, A8, A15) and 3-(4-chlorophenyl)- 5-(4-methoxybenzyl)-4H-1,2,4-triazole (B5, B9, B13) derivative compounds were evaluated in terms of their potential for mushroom tyrosinase inhibition. IC
50 values of these six molecules were determined.

Results
It was seen that B9 molecule was the most effective inhibitor. Docking studies also nearly supported this end result. Tyrosinase inhibition type and Ki value were found to be uncompetitive and 370.7±0.3 μM, respectively, in the presence of B9 compound.

Conclusion
These results suggest that B9 compound is a potential tyrosinase inhibitor.
Information Management and Companies’ Logistics Cooperation
Authors: Tomasz Lis , Paula Bajdor 
Published: December 2018

Abstract
Cooperation, regardless of its nature or involvement degree, is one of the most important factors determining the companies’ success on a dynamic market. This is caused by the need to quick adaption to changes. Using the opportunities and avoid risks is a daily task of top management.
The cooperation allows the use the capital of everyone participant involved in the process. It is thus a factor directly influencing the process of gaining the competitive advantage. Each event market, including any change, can be seen in terms of the information aspect. Collaboration at any stage is also an information process. As well as company management. It can be said that the cooperation of companies focused on success, depends on the efficiency of information management.
The aim of the article is to realize the complexity of information management. It is also awareness of the need for a comprehensive and integrated approach to the issue of information in the life of the company.
Sustainable Regional Development Policy in Romania - Coordinates
Authors: Popescu Constanta , Ristea Ana-Lucia , Popescu Constantin 
Published: December 2018

Abstract
The regional development policy appears as a coherent set of planned measures - enlisted in the National Development Programme and in the National Regional Development Plans - and promoted by the authorities of the central end local administration, based on the principle of partnership with various actors (private, public or volunteers), in order to assure a dynamic and sustainable economic and social growth, by an efficient valorification of the regional and local potential.
The definition of the regional development policy in Romania needs to answer two pressures, namely: one of general order, which imposes the acceptance of the EU rules and objectives and the coordination of the regional development policy with the way the regional development policy is understood and applied at the level of the community countries; the second, of particular order, springs from the situation Romania experiences, namely its still insufficient preparation to face the extremely competitive environment of the “unique market” within the EU.
To implement a regional development policy compatible and comparable to the EU policy in this domain, according to the “Green Charter of Regional Development in Romania”, elaborated by the Government of Romania and the European Commission, even since the year 1997, eight development regions have been defined (which must not be viewed as administrative-territorial units, as they do not have juridical personality, so that they must not be mistakenly taken for the counties).
Sino-Algerian B2B Relational Exchange via E-Marketplace: Case Study of Algerian Import Companies
Authors: Djenouhat Assia , Djaouahdou Reda 
Published: December 2018

Abstract
The objective of this paper is to investigate the influence of Sino-Algerian B2B relational exchange via e-marketplace, by examining the two instrumental dimensions of relational exchange where information exchange and flexibility were tested. Toward that goal, a survey is employed to Algerian import companies to determine the quality of relational exchange with Chinese companies when trading via e-marketplace. A conceptual framework was developed based on extended literature review and examined on data collected from 70 companies through a survey methodology. As a result, Algerian import companies have a good and strong relational exchange with Chinese companies via e-marketplace, due to high degree of transparency, just-in-time services and special facilities in language negotiation, ordering, payment methods and shipment provided by Chinese companies. Thus, non-trust on e-commerce and internet infrastructure in Algeria has affected the trust on after-purchase activities via e-marketplace. So, Algerian companies strongly trust on Chinese companies but they weakly trust on trading with them via e-marketplace.
Cost Centers from Hospital Units. Study Case
Authors: Puțan Alina , Ivan Oana Raluca , Tamas Attila 
Published: December 2018

Abstract
Current status of the hospital units is worrying: insufficient funding, increasing the number of cases considered / treated, providing quality services at public hospital unit. In this research we have undergone an empirical research carried out in the hospital units of category III and IV, from Alba County, this sample selection aims to identify an optimal solution to exercise management control which should serve to management decisionmaking. Responsibility centers, at the level of hospital unit, establish the liability for each segment of expenditure, expenditure tracking and proper grounding even their places of training, delimitation expenditure which does not strictly dependent on the production activities that are related strictly by the process; establishing the deviations of preset expenses levels; establishing a system of rules allowing highlighting the responsibilities of each performer, introducing a system of resource allocation and tracking of the use of their by developing specific cost budget for each responsibility center. The disadvantages of decentralization based on activity centers consists in increase the consumption of resources in certain activities, unclear delimitation of cause-effect relationships that create difficulties in adopting the relevant decisions by management, etc.
A Reserch regarding Targoviste’s Inhabitant’s Opinion on what are the Massage’s Benefits on Health and Wellness
Authors: Badicu Georgiana-Daniela 
Published: December 2018

Abstract
Some people consider the massage a luxury and resort to it only in case of need. But given the pressures of fashionable society, and particularly by the increases in diseases caused by stress, such therapies should become an integral part of everyday life and should be recognized as a valuable component of preventive medicine. Since ancient times, people have searched for aids to cure or alienate their suffering in pain, using primary therapeutic properties of water, sunlight and movement.
Most likely is that the initial application of massage was instinctively result in immediate experience of its healing properties. Starting from the idea that massage can be both necessity and whim, we decided to identify how massage was and find an answer to the question: “Massage - fad or necessity?”
A Case Study on Vedanta Alumina Ltd (VAL) Orissa India: State and FDI versus Democracy?
Authors: Kaushal Leena Ajit 
Published: December 2018

Abstract
Foreign investment in extractive industries in the developing economies has seldom remained free from various types of controversies. Vedanta Aluminum Ltd (VAL) integrated aluminum project in Orissa is an important project for Vedanta Resources Plc. The project suffered major setbacks as the Indian government withdrew the permission for bauxite mining in Niyamgiri and issued a show cause notice under Environment protection act in 2010 for undertaking construction activity without obtaining environmental clearance for its alumina expansion project at Lanjigarh in Kalahandi district in Orissa. This case illustrates how a decentralized policy and bureaucracy in a country like India deal with myriad problems of resource curse together with attendant consequences, despite the fact that as compared to several developing nations India has a better track record of legislative framework, an experienced bureaucracy and a regulatory framework.
There are institutional rigidities and limits of public policy formulation and implementation which adversely affect a diverse range of stakeholders: essentially because economic growth priorities override all feasible considerations of protecting and furthering stakeholder interests. India is not the only state which has undergone such an ordeal, many developing countries have suffered as well from their relative inability to deal with the issues of resource curse; but this case study assumes further significance because based on the actual final decisions a future road map in terms of a realistic public policy both for domestic investors as also foreign investors in extractive industries will be decided.
Comparative Analysis of Consulting Services in Five European Countries
Authors: Dobrea Răzvan Cătalin , Ispas Mihaela 
Published: December 2018

Abstract
The work “Comparative analysis of consulting services in five European countries” intends to offer a general picture of consulting services from five European countries (Germany, United Kingdom, Italy, Finland and Romania), through comparative analysis of the indicators presented in FEACO studies: increasing rate of turnover of the consulting market, export level, the evolution of the number of consultant, the evolution of the fees of the consultant, types of consulting services, main field where the clients that request consulting services come from.
The main motivation of this research consisted of understanding the reasons for which the transformations that occurred on the consulting market are perceived differently by each of the countries that were analysed.
A first step in the process of understanding the management consultancy is represented by defining it, first according to the vision of well-known authors, experienced consultants and secondly, according to the vision of profession organism on international and local level. In order to understand the way consultancy evolved in time it is necessary to present a short history with focus on the moments that led to the transformations which we have nowadays in this industry. The last part of the work was dedicated to the comparative analysis of the consultancy markets in the five countries. The novelty degree of the work is represented by the fact that all the strong points identified in the case of the four countries (Germany, United Kingdom, Italy, Finland) will constitute possible development directions for the Romanian consulting market.
Actions of National Bank of Romania on Bank Liquidity
Authors: Drăgoi Violeta Elena , Preda Larisa Elena 
Published: December 2018

Abstract
The central bank’s action on bank liquidity implies the action on the amount of currency issued by the central bank that banks can acquire in their mutual relationships, and on its price, which is the action on the interest rate.
In order to respond to banks’ treasury needs, the central bank acts on the money market through restrictions on refinancing options and handling reserve requirements.
The paper aims to investigate the extent to which the NBR’s money tool system influences the mass and quality of credit granted by banks in the Romanian banking system. The monetary policy strategy adopted by the NBR had a strong influence on the macroeconomic variables of Romania
The Promotion of Young Entrepreneurs for Development Small and Medium Business
Authors: Doga-Mîrzac Mariana 
Published: December 2018

Abstract
Promoting entrepreneurship is an essential component to ensure economic development at the national and the regional level. Entrepreneurship in young people may directly stimulate them and positively influence the generations and communities in which it operates.
Successful young entrepreneurs in identifying those aspects hold ideas that will contribute to the success of the business and have availability to conquer niches of business that other entrepreneurs have ignored them or have them watched in disbelief.
Over the past few years, employment of young remains one of the main problems that persist, problem on the development of market economy has boosted it and deepened it, emphasizing the correlation between the supply and demand of labour force as a whole.
Comparative Analysis between the Sports Management Systems in Romania and Norway
Authors: Popescu Ciprian Gheorghe 
Published: December 2018

Abstract
Through this analysis I wanted to emphasize the differences but also the similarities between the two countries with different management systems, in terms of geopolitical, social, technological and economic. In this analysis we found that the two systems have common point in sports management, but also points that they should priority in the next stage in the development of sport.
“Making up people”1globally. Die Institutionalisierung globaler Personenkategorien am BeispielIndigener VölkerundMenschen mit Behinderungen
Authors: Bennani Hannah , Müller Marion 
Published: December 2018

ZusammenfassungIm Zentrum des Beitrags steht die Frage nach der Herstellung und Etablierung globaler Personenkategorien im Kontext internationaler Politik. Am Beispiel der beiden noch relativ jungen Personenkategorien der „indigenen Völker“ und „Menschen mit Behinderungen“ werden Institutionalisierungsprozesse rekonstruiert und Mechanismen für die Globalisierung der kategorialen Reichweite vergleichend herausgearbeitet. Die Analyse von Textdokumenten nationaler und internationaler Organisationen zeigt sowohl einen begrifflichen Wandel der Kategorien als auch damit verbundene semantische Bedeutungsverschiebungen hin zu einer Kulturalisierung und einer Vermenschenrechtlichung. Durch die Fokussierung auf die globale Entstehung und den Wandel von Personenkategorien schließt der Beitrag die bislang eher an nationalen bzw. lokalen Kategorisierungspraktiken interessierte Soziologie der Humandifferenzierung an die Weltgesellschafts- und Globalisierungsforschung an.<fnote> Hacking 1986</fnote>
A Transition without Tradition: Earnings and Unemployment Risks of Academic versus Vocational Education after the Bologna Process
Authors: Neugebauer Martin , Weiss Felix 
Published: December 2018

ZusammenfassungHochschulbildung wird von Arbeitgebern gemeinhin honoriert. Der Bologna-Prozess hat dazu geführt, dass Bachelorabsolventen in mehreren europäischen Ländern in Arbeitsmärkte eintreten, in denen eine nur 3-jährige Hochschulausbildung ein bis dato unbekanntes Phänomen ist. Schwinden für diese Gruppe die gut dokumentierten Arbeitsmarktvorteile von Hochschulabsolventen? In Deutschland lassen sich Arbeitsmarkteintritte von Personen mit ähnlicher Ausbildungslänge und ähnlichem Ausbildungsfach vergleichen, wobei sich die eine Gruppe für eine etablierte berufliche Ausbildung und die andere Gruppe für ein neues Bachelorstudium entschieden hat. Auf Basis des Mikrozensus finden wir, dass ein universitärer Bachelorabschluss mit einem höheren Einkommen assoziiert ist als ein beruflicher Abschluss und mit einem ähnlichen Einkommen wie ein beruflicher Fortbildungsabschluss. Hinsichtlich des Arbeitslosigkeitsrisikos zeigt sich, dass Personen mit universitärem Bachelorabschlüssen am häufigsten arbeitslos sind. Bachelorabsolventen von Fachhochschulen hingegen erreichen beides, hohe Einkommen und ein geringes Arbeitslosigkeitsrisiko. Insgesamt deuten unsere Befunde darauf hin, dass akademische Bildung weiterhin nachgefragt wird und sich lohnt – auch unter den neuen Rahmenbedingungen.
Modeling Cosmic Expansion, and Possible Inflation, as a Thermodynamic Heat Engine
Authors: Pilot Christopher 
Published: December 2018

Abstract
Assuming a closed universe with slight positive curvature, cosmic expansion can be modeled as a heat engine where we define the “system,” collectively, as those regions of space within the observable universe, which will later evolve into voids. We identify the “surroundings,” collectively, as those pockets of space that will eventually develop into matter-filled galaxies, clusters, superclusters, and filament walls. Using this model, we can find the energy needed for cosmic expansion using basic thermodynamic principles and show that cosmic expansion had as its origin a finite initial energy density, pressure, volume, and temperature. Inflation in the traditional sense, with the inflaton field, may also not be required. We also argue that homogeneities and inhomogeneities in the WMAP temperature profile are attributable to quantum mechanical fluctuations about a fixed background temperature in the initial isothermal expansion phase of the cycle, which we identify with inflation. Fluctuations in temperature can cause certain regions of space to lose heat while other regions will absorb that heat. The voids, being those regions that absorb the heat, will expand, thereby leaving slightly cooler temperatures for the surroundings, where matter will later congregate. Upon freeze-out, this could produce the observed WMAP signature with its associated inhomogeneity. Finally, using the uncertainty relation, we estimate that the temperature and time for formation of WMAP inhomogeneities occurred at roughly 3.02 × 1027 K and 2.54 × 10−35 s, respectively, after first initiation of volume expansion. This is in line with current estimates for the end of the inflationary epoch. The heat input in the inflationary phase is calculated as roughly Q = 1.81 × 1094 J (photons only); the collective void volume increases by a factor of only 5.65. The bubble voids in the observable universe increase in size from about 0.046 to 0.262 m3 within this inflationary period in our model.
Electronic and magnetic properties of the 2H-NbS2 intercalated by 3d transition metal atoms
Authors: Polesya Svitlana , Mankovsky Sergiy , Ebert Hubert 
Published: December 2018

Abstract
The electronic structure and magnetic properties of the compound 2H-NbS2 intercalated by 3d elements from Cr to Ni, have been investigated using the Korringa–Kohn–Rostoker electronic structure method. Here, we consider the phases with 33% of intercalation within the ordered phase having a

3

×

3

$\sqrt 3 \times \sqrt 3 $

arrangement of the magnetic atoms. We analyze the relationship of the magnetic and electronic properties on the structural parameters dependent on the intercalant. The exchange coupling parameters calculated from first principles have been used for subsequent Monte Carlo simulations. Within these investigations, the FM order was found for the Cr and Mn intercalated phases as ground state configuration with a Curie temperature being in good agreement with the experiment. According to the Monte Carlo simulation, Fe1/3NbS2 has a complicated noncollinear magnetic structure with a noncompensated total magnetic moment, whereas Co1/3NbS2 and Ni1/3NbS2 are found to be antiferromagnetic, all in line with experimental observations.
Genuine students as partners: How a Teaching Assistant Consultant program put students as partners into practice
Authors: Gourlay Gerry , Korpan Cynthia 
Published: December 2018

In this case study, a graduate student and staff member show how an institution wide program, aimed at enhancing learning and teaching in higher education, exemplifies Matthews’s (2017) “Five Propositions for Genuine Students as Partners Practice” at the department level. To do so, we describe the five propositions in relation to the Teaching Assistant Consultant (TAC) program that positions a graduate student leader in each department to support new Teaching Assistants (TAs). Through comparison, we look at how the program is inclusive, exhibits strong power-sharing capabilities through continual reflection and conversation, is ethical, and is strongly transformative.
<i>BACILLUS</i> SPECIES IN THE OCEANIC WATERS ADJACENT TO CUBA: ASSOCIATION BETWEEN THEIR DISTRIBUTION AND METABOLIC ACTIVITY
Authors: Lugioyo Gladys Margarita , Coto Orquídea , Álvarez Carlos , Espinosa Georgina 
Published: December 2018

The aim of the present work was to identify spore-forming Gram-positive Bacillus strains isolated from oceanic waters adjacent to Cuba and to establish a possible relationship between their distribution and the metabolic activity of the isolates. Total protein patterns, derived from SDS-PAGE, were used to build a non-rooted dendrogram where the strains appeared clustered in three nodes. No direct relationship was observed between a node and particular species. In contrast, according to the physical and chemical characteristics of the zones, node I was different from node II and III, since it comprises strains from the farthest zones of the coast, poorer in nutrients. On the other hand, nodes II and III mainly collect strains isolated from nutrient and organic matter-enriched zones. Associating the node clustering with metabolic activities, it was found that in node I the ratio: number of positive activities/strain was 2.3, followed by node II with a ratio of 3.3, and finally node III exhibiting a ratio equal to 3.7. This could suggest that different total protein patterns in bacteria belonging to the same specie, but coming from environments with different degree of nutrient richness, could be an indicator of the capacities of these microorganisms to adapt and live in different environments. El objetivo del presente trabajo fue la identificación de cepas de bacilos Gram-positivos esporulados aislados de las aguas oceánicas adyacentes a Cuba y el establecimiento de la posible relación entre la distribución y las actividades metabólicas de los aislados. A partir del patrón de proteínas obtenido mediante electroforesis SDS-PAGE, se construyó un dendrograma no enraizado, lo que permitió la agrupación de las cepas en tres nodos. No se observó una relación directa entre un nodo y especies particulares, sin embargo, se encontraron diferencias entre los nodos al considerar las características físicas y químicas de las zonas; el nodo I fue diferente a los nodos II y III. En ese nodo se agruparon bacterias aisladas de zonas alejadas de la costa, pobres en nutrientes. Por otro lado, los nodos II y III agrupan principalmente a cepas aisladas de aguas más enriquecidas en nutrientes y materia orgánica. Con respecto a la asociación de los aislados en los nodos con las actividades metabólicas, se encontró que la razón entre el número de actividades positivas y el número de aislados fue de 2.3 en el nodo I, seguida del nodo II con 3.3 y por último el nodo III con 3.7. Estos resultados sugieren que, los patrones diferentes de proteínas totales en bacterias que pertenecen a la misma especie, pero que provienen de ambientes con diferente grado de riqueza en nutrientes, podrían ser un indicador de las capacidades de estos microorganismos para adaptarse y vivir en diferentes ambientes.