bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with glycemic status and ability to adapt to changing demands in people with and without type 2 diabetes mellitus: A cross-sectional study
Authors: Salazar-González Bertha Cecilia , Gallegos-Cabriales Esther C , Rivera-Castillo Alicia , González-Cantú Arnulfo , Gómez-Meza Marco Vinicio , Villarreal-Pérez Jesús Zacarías 
Published: May 2018

Objectives: Type 2 diabetes mellitus studies focus on metabolic indicators and different self-reported lifestyle or care behaviors. Self-reported instruments involve conscious process therefore responses might not reflect reality. Meanwhile implicit responses involve automatic, unconscious processes underlying social judgments and behavior. No studies have explored the combined influence of both metabolic indicators and implicit responses on lifestyle practices in type 2 diabetes mellitus patients. The purpose was to investigate the explained variance of socio-demographic, metabolic, anthropometric, clinical, psychosocial, cognitive, and lifestyle variables on glycemic status and on the ability to adapt to changing demands in people with and without type 2 diabetes mellitus in Monterrey, Mexico. Methods: Adults with (n = 30, mean age 46.90 years old, 33.33% male) and without (n = 32, mean age: 41.69 years old, 21.87% male) type 2 diabetes mellitus were studied. Glycemic status was assessed using Bio-Rad D-10 Hemoglobin A1c Program, which uses ion-exchange high-performance chromatography. Stroop 2 test was used to assess the ability to changing demands. Results: In participants with type 2 diabetes mellitus, less years of education, negative self-actualization, and higher levels of cholesterol and triglycerides explained more than 50% of the variance in glycemic status. In participants without type 2 diabetes mellitus, the variance (38.7%) was explained by total cholesterol, metabolic syndrome, high-density lipoprotein, and self-actualization scores; the latter in opposite direction. The ability to adapt to changing demands was explained by total cholesterol, malondialdehyde, insulin resistance, and triglycerides. In participants without type 2 diabetes mellitus, the contributing variables were metabolic syndrome and nutrition scores. Conclusion: Results showed significant effect on at least one of the following variables (socio-demographic, metabolic, or lifestyle subscale) on glycemic status in people with and without type 2 diabetes mellitus. The ability to adapt to changing demands was explained by metabolic variables but only in participants without type 2 diabetes mellitus. Preference for unhealthy behaviors (implicit or automatic responses) outweighs healthy lifestyle practices in people with and without type 2 diabetes mellitus.
Long-term results of intravitreal bevacizumab and dexamethasone for the treatment of punctate inner choroidopathy associated with choroidal neovascularization: A case series
Authors: Tsaousis Konstantinos T , Nassr Mohamed , Kapoor Bharat , Konidaris Vasileios E , Tyradellis Straton , Empeslidis Theo 
Published: May 2018

Introduction: To present a case series of three female patients with punctate inner choroidopathy. We report the outcomes after an essentially long follow-up period of up to 14 years and provide evidence of the effectiveness of intravitreal injections of bevacizumab and dexamethasone 0.7 mg in punctate inner choroidopathy patients with choroidal neovascular membrane formation. Case series presentation: This is a retrospective case series of three female patients with punctate inner choroidopathy who were treated with intravitreal injections anti-vascular endothelial growth factor agent (bevacizumab, 1.25 mg/0.05 mL). Two patients also received intravitreal dexamethasone 0.7 mg. Once a choroidal neovascular membrane developed, the outcome was poor with a best-corrected visual acuity of 6/60 or counting fingers in the affected eyes. The patients were followed up for 5, 14 and 8 years. Conclusion: The use of dexamethasone 0.7 mg in punctate inner choroidopathy yielded encouraging results and long periods of stability. When choroidal neovascular membrane complicates the primary disease, the prognosis is unfavourable, especially if the macula integrity has already been considerably affected. On the contrary, aggressive early therapy and continued monthly monitoring can prevent severe fibrosis, as showed in previous reports. Further larger-scale studies are needed to evaluate the efficacy of intravitreal dexamethasone 0.7 mg and bevacizumab as an alternative treatment in non-infectious uveitis.
Prevalence of common polymorphisms of AT-rich interaction domain 1A and endothelial nitric oxide synthase in patients with endometriosis compared to control group
Authors: Tavana Zohreh , Khalili Azadeh , Namazi Golnaz , Ebrahimi Ahmad , Davoodi Sara , Alborzi Saeed , Roozmeh Shohreh 
Published: May 2018

Introduction: Endometriosis is a common gynecologic disorder defined as ectopic presence of endometrial tissue in extrauterine sites. Endometriosis is associated with infertility and risk of malignancy. Identification of genetic factors responsible for development and malignant transformation of endometriosis can improve therapeutic approaches. In this study, we investigated the association of AT-rich interaction domain 1A ( ARID1A) and endothelial nitric oxide synthase ( eNOS) polymorphisms with endometriosis and staging of the disease. Methods: A total of 100 women with laparoscopy-confirmed diagnosis of endometriosis were included and compared with 100 women without endometriosis as the control group. Genotypes of patients regarding Gln920Ter polymorphism of ARID1A gene and Glu298Asp polymorphism of eNOS gene were determined by polymerase chain reaction techniques on blood samples from the study population. The prevalence of each genotype in endometriosis patients was compared with healthy controls using the chi-square test. Results: Significantly higher prevalence of non-CC genotype for ARID1A Gln920Ter polymorphism and non-GG genotype for G894T polymorphism of the eNOS gene was detected in the endometriosis group. There was no significant relationship between these polymorphisms and staging of endometriosis. Discussion: Significant variation of prevalence of Gln920Ter polymorphism of the ARID1A gene and Glu298Asp polymorphism of the eNOS gene among the two groups can indicate a causative effect of these genetic alterations on the development of endometriosis.
Poor sensitivity of transvaginal ultrasound markers in diagnosis of superficial endometriosis of the uterosacral ligaments
Authors: Robinson Alice J , Rombauts Luk , Ades Alex , Leong Kenneth , Paul Eldho , Piessens Sofie 
Published: May 2018

Introduction: This study aims to evaluate the use of transvaginal ultrasound in predicting superficial endometriosis near the uterosacral ligaments, in women with symptoms of endometriosis. Methods: This was a prospective observational pilot study in which women with symptoms of endometriosis underwent detailed pre-operative transvaginal ultrasound to assess the uterosacral ligament area for thickening (‘white line sign’), tenderness and small hypoechoic nodules. Women with deep infiltrating endometriosis were excluded. The test characteristics of transvaginal ultrasound were reported using histologically or visually proven endometriosis near the ipsilateral uterosacral ligament as a reference standard. Results: In 81 patients who underwent pre-operative transvaginal ultrasound and laparoscopy, no marker had appropriate test characteristics for a diagnostic or screening test for endometriosis near the ipsilateral uterosacral ligament when used alone. The presence of a small hypoechoic nodule on the white line had the highest specificity of the three markers, at 82% (95% confidence interval 66%–92%). Quantitative measurement of the white line also achieved a high specificity of ≥96% using a cut-off of 5.8 and 6.1 mm, on the left and right sides, respectively. Conclusion: Transvaginal ultrasound of the uterosacral ligament area using the three proposed markers is not a clinically useful screening test for superficial endometriosis near the uterosacral ligaments. A grossly thickened white line (≥5.8 mm) and/or the presence of small hypoechoic nodules are highly specific findings for superficial endometriosis near the uterosacral ligaments and may prompt surgical management.
Significance of compositional zoning in cumulate chromites of the Kabanga chonoliths, Tanzania
Authors: Evans David M. 
Published: May 2018

ABSTRACTCompositional zoning is observed rarely in chrome-spinel grains from slowly-cooled layered intrusions because diffusion of cations continues within the spinel to low temperatures. However, in certain circumstances, such gradational zoning of both divalent and trivalent cations is observed and may be useful in deciphering the thermal history of the host intrusions. The accessory chrome-spinels of the Kabanga mafic-ultramafic chonolith intrusions of the Kibaran igneous event in north western Tanzania are notable because they have preserved gradational compositional zoning. This zoning is demonstrated to predate and be independent of later hydrous alteration of the silicate assemblage. At Kabanga, most chrome-spinel grains within olivine-rich cumulate rocks are gradationally and cryptically zoned from Fe2+-Cr3+ rich cores to more Mg2+-Al3+ rich rims (normal zoning). A few grains are zoned from Mg2+-Al3+ rich cores to more Fe2+-Cr3+ rich rims (reverse zoned). The zoning of divalent cations is proportional to that of trivalent cations with Mg2+ following Al3+ and Fe2+ following Cr3+ from core to rim. The zoning of trivalent and tetravalent cations is interpreted to be caused by either new growth from an evolving melt or peritectic reactions between evolved or contaminated melt and adjacent Al-Cr-bearing ferromagnesian minerals, which is preserved by relatively rapid initial cooling in the small chonolith intrusions. Divalent cation zoning is controlled by sub-solidus exchange of Fe2+ and Mg with adjacent ferromagnesian minerals and continues to lower temperatures, indicated to be 580 to 630°C by the spinel-olivine geothermometer. Preservation of such zoning is more likely in the smaller chonolith intrusions that typically host magmatic nickel-copper sulfide deposits and can be used as an exploration indicator when interpreting chromite compositions in regional heavy indicator mineral surveys.
Phase Ib Trial With Birabresib, a Small-Molecule Inhibitor of Bromodomain and Extraterminal Proteins, in Patients With Selected Advanced Solid Tumors
Authors: Lewin Jeremy , Soria Jean-Charles , Stathis Anastasios , Delord Jean-Pierre , Peters Solange , Awada Ahmad , Aftimos Philippe G. , Bekradda Mohamed , Rezai Keyvan , Zeng Zhen , Hussain Azher , Perez Susan , Siu Lillian L. , Massard Christophe 
Published: May 2018

Purpose Birabresib (MK-8628/OTX015) is a first-in-class bromodomain inhibitor with activity in select hematologic tumors. Safety, efficacy, and pharmacokinetics of birabresib were evaluated in patients with castrate-resistant prostate cancer, nuclear protein in testis midline carcinoma (NMC), and non–small-cell lung cancer in this phase Ib study. Patients and Methods Forty-seven patients were enrolled to receive birabresib once daily at starting doses of 80 mg continuously (cohort A) or 100 mg for 7 consecutive days (cohort B) in 21-day cycles using a parallel dose escalation 3 + 3 design. The primary objective was occurrence of dose-limiting toxicities (DLTs) and determination of the recommended phase II dose. Results Of 46 treated patients, 26 had castrate-resistant prostate cancer, 10 NMC, and 10 non–small-cell lung cancer. For cohort A, four of 19 (21%) evaluable patients had DLTs at 80 mg once daily (grade 3 thrombocytopenia [n = 3], ALT/hyperbilirubinemia [n = 1]) and two of three had DLTs at 100 mg once daily (grade 2 anorexia and nausea with treatment delay > 7 days [n = 1], grade 4 thrombocytopenia [n = 1]). No DLTs occurred in cohort B. Of 46 patients, 38 (83%) had treatment-related adverse events (diarrhea, 17 [37%]; nausea, 17 [37%]; anorexia, 14 [30%]; vomiting, 12 [26%]; thrombocytopenia 10 [22%]). Three patients with NMC (80 mg once daily) had a partial response (Response Evaluation Criteria in Solid Tumors [RECIST] version 1.1) with duration of 1.4 to 8.4 months. Pharmacokinetic analysis indicated a dose-proportional increase in birabresib exposure and rapid absorption. Conclusion The recommended phase II dose of birabresib in patients with select solid tumors is 80 mg once daily with continuous dosing. Birabresib has dose-proportional exposure and a favorable safety profile, with clinical activity observed in NMC. Future studies of birabresib must consider intermittent scheduling to possibly mitigate the toxicities of chronic dosing.
The Intestinotrophic Effects of Glucagon-Like Peptide-2 in Relation to Intestinal Neoplasia
Authors: Orhan Adile , Gögenur Ismail , Kissow Hannelouise 
Published: May 2018

Abstract

Context
Glucagon-like peptide-2 (GLP-2) is a gastrointestinal hormone with intestinotrophic and antiapoptotic effects. The hormone’s therapeutic potential in intestinal diseases and relation to intestinal neoplasia has raised great interest among researchers. This article reviews and discusses published experimental and clinical studies concerning the growth-stimulating and antiapoptotic effects of GLP-2 in relation to intestinal neoplasia.

Evidence Acquisition
The data used in this narrative review were collected through literature research in PubMed using English keywords. All studies to date examining GLP-2’s relation to intestinal neoplasms have been reviewed in this article, as the studies on the matter are sparse.

Evidence Synthesis
GLP-2 has been found to stimulate intestinal growth through secondary mediators and through the involvement of Akt phosphorylation. Studies on rodents have shown that exogenously administered GLP-2 increases the growth and incidence of adenomas in the colon, suggesting that GLP-2 may play an important role in the progression of intestinal tumors. Clinical studies have found that exogenous GLP-2 treatment is well tolerated for up to 30 months, but the tolerability for even longer periods of treatment has not been examined.

Conclusion
Exogenous GLP-2 is currently available as teduglutide for the treatment of short bowel syndrome. However, the association between exogenous GLP-2 treatment and intestinal neoplasia in humans has not been fully identified. This leads to a cause for concern regarding the later risk of the development or progression of intestinal tumors with long-term GLP-2 treatment. Therefore, further research regarding GLP-2’s potential relation to intestinal cancers is needed.
Orthorexia nervosa – a separate clinical entity, a part of eating disorder spectrum or another manifestation of obsessive-compulsive disorder?
Authors: Łucka Izabela , Janikowska-Hołoweńko Dorota , Domarecki Patryk , Plenikowska-Ślusarz Teresa , Domarecka Małgorzata 
Published: May 2018

Cel pracyCelem pracy było zbadanie rozpowszechnienia ortoreksji w populacji losowo wybranej, uczącej się młodzieży i młodych dorosłych oraz próba znalezienia odpowiedzi: czy ortoreksja jest oddzielną jednostką chorobową, rodzajem zaburzeń odżywiania czy raczej wariantem zaburzeń obsesyjno-kompulsywnych.MetodaMateriał i Metoda: Grupę badaną stanowiły 864 osoby, w tym 599 kobiet i 265 mężczyzn. Średnia wieku kobiet wynosiła 20,21 +/- 3,27 lat zaś mężczyzn to 18,93 +/- 3,67 lat. W badaniu zastosowano autorski kwestionariusz zbierający podstawowe informacje o osobach badanych oraz kwestionariusze diagnostyczne: ORTO-15 opracowany przez Doniniego i wsp., (walidacja w Polsce – Janas-Kozik i wsp.), EAT-26 autorstwa Garnera i Garfinkela, MOCI (Maudsley Obsessive Compulsive Inventory) przygotowany przez Hodgsona i Rachmana. Wyniki opracowano za pomocą metod statystycznych.WynikiWyniki: Na podstawie przeprowadzonego badania ryzyko występowania ortoreksji stwierdzono u 27% badanych (za punkt odcięcia przyjęto wynik 35). Osoby te uzyskały istotnie wyższe wyniki w teście zaburzeń odżywiania EAT. Nie stwierdzono istotnych statystycznie różnic w wynikach testu MOCI. Najwyższy wskaźnik ryzyka ortoreksji zaobserwowano w grupie gimnazjalistów, najniższe nasilenie zachowań ortorektycznych wśród licealistów. Osoby, u których można podejrzewać ortoreksję mają istotnie wyższy wskaźnik BMI. Szczegółowa analiza czynników środowiskowych zostanie przedstawiona w kolejnym doniesieniu.WnioskiWnioski. Na podstawie przeprowadzonego badania uważamy, że ortoreksja nie stanowi odrębnej jednostki chorobowej. Wpisuje się ona w spektrum zaburzeń odżywiania. Nie potwierdziliśmy związku pomiędzy zaburzeniami obsesyjno kompulsywnymi a ortoreksją.
Strategic Commitment to a Production Schedule with Uncertain Supply and Demand: Renewable Energy in Day-Ahead Electricity Markets
Authors: Sunar Nur , Birge John R. 
Published: May 2018

We consider a day-ahead electricity market that consists of multiple competing renewable firms (e.g., wind generators) and conventional firms (e.g., coal-fired power plants) in a discrete-time setting. The market is run in every period, and all firms submit their price-contingent production schedules in every day-ahead market. Following the clearance of a day-ahead market, in the next period, each (renewable) firm chooses its production quantity (after observing its available supply). If a firm produces less than its cleared day-ahead commitment, the firm pays an undersupply penalty in proportion to its underproduction. We explicitly characterize firms’ equilibrium strategies by introducing and analyzing a supply function competition model. The purpose of an undersupply penalty is to improve reliability by motivating each firm to commit to quantities it can produce in the following day. We prove that in equilibrium, imposing or increasing a market-based undersupply penalty rate in a period can result in a strictly larger renewable energy commitment at all prices in the associated day-ahead market, and can lead to lower equilibrium reliability in all periods with probability 1. We also show in an extension that firms with diversified technologies result in lower equilibrium reliability than single-technology firms in all periods with probability 1.The electronic companion is available at https://doi.org/10.1287/mnsc.2017.2961 .This paper was accepted by Serguei Netessine, operations management.
Multidimensional Bargaining and Inventory Risk in Supply Chains: An Experimental Study
Authors: Davis Andrew M. , Hyndman Kyle 
Published: May 2018

We study the impact of multidimensional bargaining and the location of inventory risk on the performance of a two-stage supply chain. We conduct a controlled human subjects experiment where a retailer and supplier either interact through ultimatum offers or dynamically bargain over contract terms, including a wholesale price and, potentially, an order quantity. We also manipulate whether the risk associated with unsold inventory lies with the retailer or the supplier or is endogenously determined in the bargaining process. One key insight is that supply chain efficiency is significantly higher when the order quantity is included in the negotiation and that, contrary to the normative theory, this leads to a Pareto improvement whereby both the supplier and retailer earn higher profits. A second important result, also counter to the normative theory, is that the party incurring the cost of unsold inventory always earns a lower profit than its counterpart, regardless of the bargaining environment or inventory risk location. To explain these data, we posit that retailers and suppliers are affected by an anchoring bias and demonstrate that it can explain many of our results. Data and the online appendix are available at https://doi.org/10.1287/mnsc.2017.2985 . This paper was accepted by Gad Allon, operations management.
Forecasting New Product Life Cycle Curves: Practical Approach and Empirical Analysis
Authors: Hu Kejia , Acimovic Jason , Erize Francisco , Thomas Douglas J. , Van Mieghem Jan A. 
Published: May 2018

We present an approach to forecast customer orders of ready-to-launch new products that are similar to past products. The approach fits product life cycle (PLC) curves to historical customer order data, clusters the curves of similar products, and uses the representative curve of the new product’s cluster to generate its forecast. We propose three families of curves to fit the PLC: bass diffusion curves, polynomial curves, and simple piecewise-linear curves (triangles and trapezoids). Using a large data set of customer orders for 4,037,826 units of 170 Dell computer products sold over three and a half years, we compare goodness of fit and complexity for these families of curves. Fourth-order polynomial curves provide the best in-sample fit with piecewise-linear curves a close second. Using a trapezoidal fit, we find that the PLCs in our data have very short maturity stages; more than 20% have no maturity stage and are best fit by a triangle. The fitted PLC curves of similar products are clustered either by known product characteristics or by data-driven clustering. Our key empirical finding is that, for our large data set, data-driven clustering of simple triangles and trapezoids, which are simple to estimate and explain, perform best for forecasting. Our conservative out-of-sample forecast evaluation, using data-driven clustering of triangles and trapezoids, results in mean absolute errors approximately 2%–3% below Dell’s forecasts. We also apply our method to a second data set of a smaller company and find consistent results. The online appendix is available at https://doi.org/10.1287/msom.2017.0691 .
Biogeochemical Oceanographic Data Assimilation: Dimensionality Reduced Kalman Filter For Mediterranean Sea Forecasting
Authors: Spada Simone , Cossarini Gianpiero , Salon Stefano , Maset Stefano 
Published: May 2018

Data assimilation is a key element to improve the performance of biogeochemical ocean/marine forecasting systems. Handling the very big dimension of the state vector of the system (often of the order of 106) remains an issue, also considering the computational efficiency of operational systems. Indeed, simple product operations involving the covariance matrices are too heavy to be computed for operational forecasting purposes. Various attempts have been made in literature to reduce the complexity of this task, often adding strong hypotheses to simplify the problem and decrease the computational cost.
The MedBFM model system, which is responsible for monitoring and forecasting the biogeochemical state of the Mediterranean Sea within the European Copernicus Marine Services (see http://marine.copernicus.eu/) assimilates surface chlorophyll data through a 3D Variational algorithm, that decomposes the background error covariance matrix into sequential operators to reduce complexity.
In this work, we developed a novel Kalman Filter for the MedBFM system. The novel Kalman Filter scheme starts from a SEIK approach but benefits from advanced Principal Component Analysis to reduce the dimension of covariance matrices and improve the computational efficiency.
We compared the standard SEIK filter and the new Kalman filter implementations in a one dimensional transport model with 2 biological variables in terms of root mean square distance. In the vast majority of the experiments, the new Kalman filter had better performances.