bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consideration of Stretchable Dry Electrodes for Smart Shirts Aimed for Biological Signal Monitoring
Authors: AMANO YUSAKU , TADA YASUNORI , SATO TOMONOBU , SAITO SHIGERU , INOUE MASAHIRO 
Published: March 2018

SUMMARYDry electrodes of a smart shirt for measuring biological signals were prepared by the additive printing method using a stretchable conductive paste with Ag fillers loading. Interfacial impedance between the electrode and skin depended on the contact pressure of electrode and the moisture of stratum corneum. When moisture of stratum corneum was more than 30%, ECG could be measured using the stretchable electrodes printed on a compression shirt. However, noise signal in the ECG signal increased when the moisture of stratum corneum was less than 30%. To solve this problem, we propose to use additional electrodes made of an electrically conductive kneaded rubber.
The impact of ischemia‐reperfusion injuries on skin resident murine dendritic cells
Authors: Goh Chi Ching , Evrard Maximilien , Chong Shu Zhen , Tan Yingrou , Tan Leonard De Li , Teng Karen Wei Weng , Weninger Wolfgang , Becker David Laurence , Tey Hong Liang , Newell Evan William , Liu Bin , Ng Lai Guan 
Published: March 2018

AbstractPressure ulcers are a chronic problem for patients or the elderly who require extended periods of bed rest. The formation of ulcers is due to repeated cycles of ischemia‐reperfusion (IR), which initiates an inflammatory response. Advanced ulcers disrupt the skin barrier, resulting in further complications. To date, the immunological aspect of skin IR has been understudied, partly due to the complexity of the skin immune cells. Through a combination of mass cytometry, confocal imaging and intravital multiphoton imaging, this study establishes a workflow for multidimensionality single cell analysis of skin myeloid cell responses in the context of IR injury with high spatiotemporal resolution. The data generated has provided us with previously uncharacterized insights into the distinct cellular behavior of resident dendritic cells (DCs) and recruited neutrophils post IR. Of interest, we observed a drop in DDC numbers in the IR region, which was subsequently replenished 48h post IR. More importantly, in these cells, we observe an attenuated response to repeated injuries, which may have implications in the subsequent wound healing process.
Capillary electrophoresis in association with chemometrics approach for bitterness hop (Humulus lupulus L.) classification
Authors: Duarte Lucas Mattos , Adriano Luiz Henrique Cantarino , de Oliveira Marcone Augusto Leal 
Published: March 2018

AbstractThe precursor compounds related to the bitterness of beer are called α‐acids. These compounds are extracted from the hop, which is an important ingredient in the brewing process. These compounds were analyzed by capillary electrophoresis. The electrophoretic method used 160 mmol/L of ammonium carbonate (pH 9) as BGE (background electrolyte), a voltage of +20 kV in a capillary with 50 μm of internal diameter and with a 62.5 cm of total length (54 cm effective). The samples were injected in hydrodynamic mode applying a pressure of 25 mbar for 5 s and the analytes were detected at 230 nm. A hydromethanolic extraction during 3 h was considered as the optimum condition for the sample preparation using MeOH/H2O 80:20 v/v as the extract solution. From the optimized conditions the electropherograms were evaluated for their use as input for chemometric modeling. Preprocessing investigation for electrophoretic data taking into account the alignment, denoising and baseline correction, and variable selection were considered before the chemometric modeling using principal component analysis (PCA). The electrophoretic data were systematically evaluated to find the optimum conditions to modeling. A PCA analysis for all tests was carried out using different preprocessing methods and, an explained variance higher than 90% was achieved in all of them. The optimized chemometric method worked with aligned and meancentered data. From this approach, a simple and efficient method to classify hop samples with high and low α‐acids content without the use of analytical standards was established from a simple electrophoretic analysis.
Powering Lights with Piezoelectric Energy‐Harvesting Floors
Authors: Puscasu Onoriu , Counsell Nathan , Herfatmanesh Mohammad R. , Peace Richard , Patsavellas John , Day Rodney 
Published: March 2018

AbstractThe present work introduces a new technology for converting energy from steps into electricity. It starts with a study of the mechanical energy available from steps in a busy corridor. The subsequent development efforts and devices are presented, with an iterative approach to prototyping. Methods for enhancing the piezoelectric conversion efficiency have been determined as a part of the process and are introduced in the present article. Capitalizing on these findings, we have fabricated energy‐harvesting devices for stairs that power embedded emergency lighting. The typical working unit comprises an energy‐harvesting stair nosing, a power management circuit, and an embedded light‐emitting diode that lights the tread in front of the user with an illuminance corresponding to emergency standards. The stair nosing generates up to 17.7 mJ of useful electrical energy per activation to provide up to 10.6 seconds of light. The corresponding energy density is 0.49 J per meter square and per step, with an 8.5 mm thick active layer.
Producing an evidence‐based treatment information website in partnership with people affected by multiple sclerosis
Authors: Synnot Anneliese J. , Hawkins Melanie , Merner Bronwen A. , Summers Michael P. , Filippini Graziella , Osborne Richard H. , Shapland Sue D.P. , Cherry Catherine L. , Stuckey Rwth , Milne Catherine A. , Mosconi Paola , Colombo Cinzia , Hill Sophie J. 
Published: March 2018

AbstractBackground and AimsIn earlier work, we identified that people affected by multiple sclerosis (MS) can have difficulty finding online treatment information that is up to date, trustworthy, understandable, and applicable to personal circumstances, but does not provoke confusion or negative emotional consequences. The objective was to develop online consumer summaries of MS treatment evidence (derived from Cochrane Reviews) that respond to identified treatment information needs of people affected by MS.MethodsA 2‐phase mixed‐methods project, conducted in partnership with consumers and an MS organisation. Phase 1 included review panels with consumers (Australians affected by MS) and health professionals to test paper‐based treatment summaries before development, and pilot testing of the website. Phase 2 involved an online survey after website launch.ResultsEighty‐three participants (85% affected by MS) took part. Phase 1 participants strongly endorsed key review summary components, including layering information, and additional sections to aid personal applicability. Participants additionally suggested questions for health professionals. Participants across both phases were receptive to the idea of being provided with Cochrane Review summaries online but were seeking other types of evidence and information, such as personal experiences and the latest experimental treatments, which could not be provided. While the small survey sample size (n = 58) limits application of the results to a broader population, the website was viewed favourably, as a useful, understandable, and trustworthy information source.ConclusionWe describe a partnership approach to developing online evidence‐based treatment information, underpinned by an in‐depth understanding of consumers' information needs.
Catalytic Membrane Reactor Model as a Laboratory for Pattern Emergence in Reaction‐diffusion‐advection Media
Authors: Yochelis Arik 
Published: March 2018

AbstractReaction‐diffusion‐advection media on semi‐infinite domains are important in chemical, biological and ecological applications, yet remain a challenge for pattern formation theory. To demonstrate the rich emergence of nonlinear traveling waves and stationary periodic states, we review results obtained using a membrane reactor as a case model. Such solutions coexist in overlapping parameter regimes and their temporal stability is determined by the boundary conditions which either preserve or destroy the translational symmetry, i. e., selection mechanisms under realistic Danckwerts boundary conditions. A brief outlook is given at the end.
Guilt in bereavement: Its relationship with complicated grief and depression
Authors: Li Jie , Tendeiro Jorge N. , Stroebe Margaret 
Published: March 2018

This study investigated the relationship between guilt and well‐being of bereaved persons, and explored potential differences in the associations between guilt‐complicated grief (CG) and guilt‐depression. In total, 1358 Chinese bereaved adults were recruited to fill out questionnaires. Participants (N = 194) who had been bereaved within 2 years of the first survey, filled out the same questionnaires 1 year later. Higher guilt was associated with higher degrees of both CG and depression. The level of guilt predicted CG and depression symptoms 1 year later. Bereavement‐related guilt has a closer association with CG than depression. Responsibility guilt, indebtedness guilt and degree of guilt feeling are more prominent aspects of guilt in CG than in depression. These findings demonstrate the significant role of guilt (perhaps a core symptom) in mental health of the bereaved, having implications for identifying persons with grief complications and depression.
Extract of Euryale ferox Salisb exerts antidepressant effects and regulates autophagy through the adenosine monophosphate‐activated protein kinase—UNC‐51‐like kinase 1 pathway
Authors: Huang Zhiheng , Huang Xiaoyan , Wang Qian , Jiang Ruizhi , Sun Guangda , Xu Yiming , Wu Qinan 
Published: March 2018

AbstractPositive regulation of autophagy by Euryale ferox Salisb (ES) leads to antidepressant effects. This study focused on the potential antidepressant mechanisms induced by the petroleum ether fraction of ES (ES‐PE) in the chronically unpredictable mild stress (CUMS) mouse model. Deficits in the sucrose preference test, open field test, tail suspension test, and forced swim test were observed following CUMS, and were reversed following ES‐PE administration. Contrary to the expression of mammalian target of rapamycin, autophagy was decreased after establishment of the CUMS model. We also observed trends for downregulation of adenosine mononphosphate‐activated protein kinase (AMPK) and mammalian autophagy‐initiating kinase (ULK1), which were differentially affected by ES‐PE. HT22 cells and Compound C, an inhibitor of AMPK, were used to verify the results in mice. Gas chromatography–mass spectrometry analysis revealed high level of vitamin E acetate in ES‐PE. Taken together, our data indicate that ES‐PE activated autophagy by regulating the AMPK pathway. © 2018 IUBMB Life, 70(4):300–309, 2018
Beneficial impact of zinc supplementation on the collagen in the bone tissue of cadmium‐exposed rats
Authors: Andrulewicz‐Botulińska Edyta , Wiśniewska Róża , Brzóska Malgorzata M. , Rogalska Joanna , Galicka Anna 
Published: March 2018

AbstractCadmium (Cd) is a toxic metal that damages bone tissue by affecting its mineral and organic components. The organic matrix is mainly (90%) composed of collagen, which determines the biomechanical strength of bone. The aim of this study was to evaluate the effect of zinc (Zn) supplementation (30 or 60 mg l–1) under moderate and relatively high exposure to Cd (5 and 50 mg l–1) on collagen in the rat tibia proximal epiphysis and diaphysis (regions abundant in trabecular and cortical bone, respectively). Significant decrease in collagen type I biosynthesis was found in both regions of the tibia in Cd‐treated rats, whereas the supplementation with Zn provided significant protection against this effect. Western blot confirmed the presence of the major type I collagen in the tibia epiphysis and diaphysis, but collagen type II was revealed only in the epiphysis. Acetic acid‐ and pepsin‐soluble collagen concentration in the tibia epiphysis and diaphysis was significantly increased due to the exposure to Cd, whereas the supplementation with Zn protected, partially or totally, from these effects, depending on the used concentration. The supplementation with Zn also provided protection from unfavorable Cd impact on the maturation of the bone collagen, as the ratio of cross‐links to monomers was higher compared to the Cd‐treated group. This report confirms our previous findings on the preventive action of Zn against harmful effects of Cd on bone, but additionally, and to the best of our knowledge for the first time, explains the possible mechanism of the beneficial influence of this bioelement.
Front Cover: Assessment of trans‐scleral iontophoresis delivery of lutein to the human retina (J. Biophotonics 3/2018)
Authors: Lombardo Marco , Villari Valentina , Micali Norberto , Roy Pierre , Sousa Sara H. , Lombardo Giuseppe 
Published: March 2018

Trans‐scleral iontophoresis device was shown to be effective for in‐situ delivery of lutein to the retina of human donor eyes. After treatment, Resonance Raman Spectroscopy measurements demonstrated that lutein greatly enriched the inner sclera, choroid and retina. Clinical studies are going to prove if the methodology would be a valuable approach to enrich the human macular pigment and prevent local oxidative damage in patients at risk of AMD progression.Further details can be found in the article by Marco Lombardo et al. (e201700095).
image
Evaluation of the Virclia® automated chemiluminescent immunoassay system for diagnosing pneumonia caused by Mycoplasma pneumoniae
Authors: Ortiz de la Tabla Victoria , Berruezo Marta , García Payá Elena , Fernández Marta , García José Alberto , Masiá Mar , Gutiérrez Félix 
Published: March 2018

BackgroundMycoplasma pneumoniae is considered an important etiologic agent of community‐acquired pneumonia (CAP) in outpatients. We aimed to evaluate the diagnostic accuracy of a quick automated chemiluminescent immunoassay (CLIA) for M. pneumoniae in a population‐based prospective study of CAP.MethodsA total of 137 outpatients diagnosed with CAP were included in the study. Acute‐ and convalescent phase sera were analyzed for IgG and IgM to M. pneumoniae with both CLIA (VirClia®) and ELISA immunoassays. Conventional serological criteria by quantitative ELISA were considered as reference standard. Sensitivity and specificity of the assay were assessed with the construction of receiver operating characteristic (ROC) curves, and the kappa index was used to evaluate the accuracy of the IgG and IgM determinations in the acute phase.ResultsThirty‐eight patients were diagnosed with pneumonia by M. pneumoniae. ROC curves for IgG and IgM of convalescent and acute phase (C/A) quotients by the CLIA and ELISA assays were comparable. Specifically, for the CLIA, the best C/A quotient for IgG was 2.617 (sensitivity, 94.9%; specificity, 99.9%), and for IgM 1.400 (sensitivity, 65.8%; specificity, 100%). Regarding the acute phase, the best diagnostic accuracy for the CLIA was obtained with an IgG index of 1.120 (sensitivity, 89.5%; specificity, 73.7%). The CLIA was very simple to execute and required a minimum sample handling.ConclusionThe accuracy of the Virclia® assay for the diagnosis of M. pneumoniae infection in outpatients with CAP was equivalent to the quantitative ELISA. The CLIA was quicker to perform and displayed better analytic workability than conventional ELISA.
Streamlining screening of emotional function in Veterans with traumatic brain injury
Authors: Flaherty Jennifer M. , Spencer Robert J. , Drag Lauren L. , Pangilinan Percival H. , Bieliauskas Linas A. 
Published: March 2018

AbstractObjectivesThis study examined how depression, anxiety, and sleep items from the Neurobehavioral Symptom Inventory (NSI) predict results from longer inventories.MethodThis was a retrospective review from 484, predominantly male (96.1%) Veterans, mean age 29.7 years, who underwent brief neuropsychological screening during a comprehensive, multidisciplinary evaluation for mild traumatic brain injury (TBI). Participants completed the NSI, insomnia severity index (ISI), and hospital anxiety and depression scale (HADS).Results: Overall,97.1% who endorsed “severe”/“very severe” anxiety on the NSI had significant anxiety on the HADS; 85% reporting “severe”/“very severe” depression on the NSI, had significant depression on the HADS; and 97.7% reporting “severe”/“very severe” sleep problems on the NSI, had significant sleep difficulties on the ISI.ConclusionClose correspondence between “severe”/“very severe” symptoms on the NSI and lengthier checklists suggests additional checklists may be eliminated and individuals can be referred for mental health treatment. NSI reports of “mild”/“moderate” require further screening.
Changes in tropical cyclone activity in north Indian Ocean during satellite era (1981–2014)
Authors: Balaji M. , Chakraborty Arun , Mandal M. 
Published: March 2018

Recent findings have raised the debate on increase in tropical cyclone activity (TCA) in major tropical ocean basins like North Atlantic and western North Pacific. To address the similar evidence in North Indian Ocean (NIO) basins, an attempt has been made in the present study to investigate TCA in NIO basins in the context of warmer climate during the satellite era (1981–2014). The most suitable cyclone energy metric called accumulated cyclone energy (ACE) is estimated for this purpose. A statistical change‐point analysis is conducted to detect the shift in ACE during the study period. Environmental factors influencing TCA are investigated to infer possible causes in the observed variability.The results indicate the increasing trend in ACE in NIO during satellite era with statistical significance of 95%. The frequency and duration of intense cyclones (wind speed >64 knots) show notable increase in recent years. However, a decreasing trend is observed in total frequency. The change‐point analysis of ACE in NIO reveals objectively that the shift occurs in 1997, with 20.8 ACE during 1981–1996 and 41.4 ACE during 1997–2014. The analysis reveals that increase in number and duration of very severe cyclonic storm (VSCS) (wind speed >64 knots) in the recent epoch (1997–2014) is the major cause for the observed twofold increase in ACE. Also, the mean genesis location of intense BoB cyclones exposes a longitudinal eastwards shift of 2.3° in the recent epoch, which could have aided the longevity of intense cyclones. Analysis of sea surface temperature (SST), upper ocean heat content (UOHC) and genesis potential index (GPI) climatology shows a positive agreement to the observed shift in genesis. The analysis of seven environmental factors shows substantial agreement with the increase and variability of ACE. Predominantly, atmospheric water vapour and SST show better correlation (.72 and .66) with ACE in NIO.
Micro‐method to determine iron concentrations in plant tissues using 2,2′ bipyridine
Authors: Hartmann Julia , Asch Folkard 
Published: March 2018

AbstractResearch often needs to determine iron (Fe) concentrations in plant tissue samples. Current established methods depend on equipment and often require skilled laboratory staff, large sample sizes, and are relatively slow and expensive. We propose an efficient and fast method for measuring Fe concentrations of small rice samples via a microplate reader using sodium dithionite (SDT) as reducing agent and dipyridyl (DPD) as coloring agent. The results show that the method yields results comparable to ICP‐OES measurements which were used as standard method. Different concentrations of the chemicals used were tested for extraction, reducing power, and coloring efficiency, to optimize the method for the range of concentrations to be expected in rice under toxic Fe conditions. Best results were obtained using 500 mM SDT and 10 mM DPD, a sample size of 0.01g dry weight, and Fast Prep as extraction method. A linear calibration curve was obtained for 0 to 100 mg kg−1 iron within the measured samples.The method proposed here was successfully applied to measure total Fe concentration in oven‐dried, milled plant samples. Applicability of the method for tissues other than rice and suboptimal extraction methods are discussed.
Cover Image, Volume 98, Issue 5
Authors: Olukosi Oluyinka A , Xiao Weiwei , Jia Jing 
Published: March 2018

The cover image, by Oluyinka A. Olukosi et al., is based on the Research Article Peptide supplementation to nutrient‐adequate diets enhanced internal egg quality during storage in hens at peak production, DOI: 10.1002/jsfa.8661. Photo Credit: Oluyinka A. Olukosi, Scotland's Rural College
image
Role of staging laparoscopy in the management of Pancreatic Duct Carcinoma (PDAC): Single‐center experience from a tertiary hospital in Brazil
Authors: de Jesus Victor Hugo Fonseca , da Costa Junior Wilson Luiz , de Miranda Marques Tomás Mansur Duarte , Diniz Alessandro Landskron , de Castro Ribeiro Héber Salvador , de Godoy André Luis , de Farias Igor Correia , Coimbra Felipe José Fernandez 
Published: March 2018

BackgroundProper staging is critical to the management of pancreatic ductal carcinoma (PDAC). Laparoscopy has been used to stage patients without gross metastatic disease with variable success.ObjectivesWe aimed to identify the frequency of patients diagnosed by laparoscopy with occult metastatic disease. Also, we looked for variables related to a higher chance of occult metastasis.MethodsPatients with PDAC submitted to staging laparoscopy either immediately before pancreatectomy or as a separate procedure between January 2010 and December 2016 were included. None presented gross metastatic disease at initial staging. We used logistic regression to search for variables associated with metastatic disease.ResultsThe study population consisted of 63 patients. Among all patients, nine (16.7%) had occult metastases at laparoscopy. Unresectable tumor (Odds ratio = 18.0, P = 0.03), increasing tumor size (Odds ratio = 1.36, P = 0.01), and abdominal pain (Odds ratio = 5.6, P = 0.04) significantly predicted the risk of occult metastases in univariate analysis. In multivariate analysis, only tumor size predicted the risk of occult metastases.ConclusionLaparoscopy remains a valuable tool in PDAC staging. Patients with either large or unresectable tumors, or presenting with abdominal pain present the highest risk for occult intra‐abdominal metastases.
Anthropogenic influences on riverine fluxes of dissolved inorganic carbon to the oceans
Authors: Raymond Peter A. , Hamilton Stephen K. 
Published: March 2018

AbstractBicarbonate (), the predominant form of dissolved inorganic carbon in natural waters, originates mostly from watershed mineral weathering. On time scales of decades to centuries, riverine fluxes of to the oceans and subsequent reactions affect atmospheric CO2, global climate and ocean pH. This review summarizes controls on the production of from chemical weathering and its transport into river systems. The availability of minerals and weathering agents (carbonic, sulfuric, and nitric acids) in the weathering zone interact to control production, and water throughput controls transport into rivers. Human influences on fluxes include climate warming, acid precipitation, mining, concrete use, and agricultural fertilization and liming. We currently cannot evaluate the net result of human influences on a global scale but fluxes are clearly increasing in some major rivers as shown here for much of the United States. This increase could be partly a return to pre‐industrial fluxes as anthropogenic acidification has been mitigated in the United States, but elsewhere around the world anthropogenic acidification could be leading to decreased concentrations and fluxes.