bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comorbid fibromyalgia: A qualitative review of prevalence and importance
Authors: Fitzcharles M.‐A. , Perrot S. , Häuser W. 
Published: May 2018

AbstractFibromyalgia (FM) may be an unrecognized cause of suffering for persons with an array of medical conditions. This is especially true for illness that is characterized by pain of any nature. Once believed to be a unique diagnosis, FM is recently reported to occur concomitantly with various rheumatic diseases, and importantly adversely impacts global health status. However, there is increasing report of FM associated with other diseases that are not defined by chronic pain. This qualitative review examines the evidence for comorbid FM in illness, and where available the effect of FM on the primary disease. Other than for musculoskeletal disorders, the published literature reporting an association of FM with illness is limited with scanty reports for some neurological, gastrointestinal, mental health and other overlapping pain conditions. Comorbid FM adversely affects both health status and outcome for rheumatic diseases, but with limited study in other diseases. When unrecognized, comorbid FM may be mistaken as poor control of the primary disease, leading to incorrect treatment decisions. FM may be a neglected condition that pervades many conditions and may contribute to the burden of illness. Physicians should be alert to the possibility of comorbid FM, and symptoms of FM should be specifically addressed.SignificanceComorbid fibromyalgia (FM) in other medical conditions is largely unrecognized. When reported as accompanying rheumatic diseases, FM adversely affects global health status. With limited reports of comorbid FM with other conditions, neglect to diagnose comorbid FM may misdirect treatments.
Forest fire effects on groundwater in a coastal aquifer (Ravenna, Italy)
Authors: Giambastiani Beatrice M. S. , Greggio Nicolas , Nobili Giovanni , Dinelli Enrico , Antonellini Marco 
Published: May 2018

AbstractWe examined the fire‐induced changes in groundwater recharge rate. This aspect is particularly important in the case of large forested areas growing over a coastal aquifer affected by saltwater intrusion. In the Ravenna coastal area (Italy), pine forests grow on coastal dune belts, overlying a sandy unconfined aquifer, which is strongly affected by marine ingression. Three groundwater profiles across the forest and perpendicular to the coastline were monitored for groundwater level, physical, and chemical parameters. The aims were to define groundwater quality, recharge rate, freshwater volume, and highlight change, which occurred after a forest fire with reference to pre‐fire conditions. Analytical solutions based on Darcy Law and the Dupuit Equation were applied to calculate unconfined flow and compare recharge rates among the profiles. The estimated recharge rates increased in the partially and completely burnt areas (219 and 511 mm year−1, respectively) compared with the pristine pine forest area (73 mm year−1). Although pre‐fire conditions were similar in all monitored profiles, a post‐fire decrease in salinity was observed across the burnt forest, along with an increase in infiltration and freshwater lens thickness. This was attributed to decrease canopy interception and evapotranspiration caused by vegetation absence after the fire. This research provided an example of positive forest fire feedback on the quantity and quality of fresh groundwater resources in a lowland coastal aquifer affected by saltwater intrusion, with limited availability of freshwater resources. The fire provided an opportunity to evaluate a new forest management approach and consider the restoration and promotion of native dune herbaceous vegetation.
Rotations in Excited ICT States – Fluorescence and its Microenvironmental Sensitivity
Authors: Liese David , Haberhauer Gebhard 
Published: May 2018

AbstractFluorescence spectroscopy as an analytical tool for various applications as well as fluorescence probes showing a sensitive behavior towards their microenvironmental properties have experienced an increasing interest in research in the last decades. Recently our group has contributed to this field of interest by introducing a novel mechanism where a planarization in the excited state occurs leading to an advantageous allowed emission. Here, we provide an overview of intramolecular charge transfer states where a rotation in the excited state causes a high sensitivity for microenvironmental changes. Furthermore, effects which influence the surroundings of the fluorophores are described in detail. Recent results where twisted intramolecular charge transfer (TICT) and aggregation‐induced emission (AIE) effects were combined are described and a promising outlook for further research progress is provided.
DISCOVERING FRUGAL INNOVATIONS THROUGH DELIVERING EARLY CHILDHOOD HOME‐VISITING INTERVENTIONS IN LOW‐RESOURCE TRIBAL COMMUNITIES
Authors: Barlow Allison , McDaniel Judy A. , Marfani Farha , Lowe Anne , Keplinger Cassie , Beltangady Moushumi , Goklish Novalene 
Published: May 2018

ABSTRACTEarly childhood home‐visiting has been shown to yield the greatest impact for the lowest income, highest disparity families. Yet, poor communities generally experience fractured systems of care, a paucity of providers, and limited resources to deliver intensive home‐visiting models to families who stand to benefit most. This article explores lessons emerging from the recent Tribal Maternal and Infant Early Childhood Home Visiting (MIECHV) legislation supporting delivery of home‐visiting interventions in low‐income, hard‐to‐reach American Indian and Alaska Native communities. We draw experience from four diverse tribal communities that participated in the Tribal MIECHV Program and overcame socioeconomic, geographic, and structural challenges that called for both early childhood home‐visiting services and increased the difficulty of delivery. Key innovations are described, including unique community engagement, recruitment and retention strategies, expanded case management roles of home visitors to overcome fragmented care systems, contextual demands for employing paraprofessional home visitors, and practical advances toward streamlined evaluation approaches. We draw on the concept of “frugal innovation” to explain how the experience of Tribal MIECHV participation has led to more efficient, effective, and culturally informed early childhood home‐visiting service delivery, with lessons for future dissemination to underserved communities in the United States and abroad.
The enhancement of osseointegration using a graphene oxide/chitosan/hydroxyapatite composite coating on titanium fabricated by electrophoretic deposition
Authors: Suo Lai , Jiang Nan , Wang Yan , Wang Puyu , Chen Junyu , Pei Xibo , Wang Jian , Wan Qianbing 
Published: May 2018

AbstractTitanium (Ti) has been commonly used as an implant material in dentistry and bone surgery for several decades. Meanwhile, surface modification of titanium can enhance the osseointegration of implants. In this study, a graphene oxide/chitosan/hydroxyapatite (GO/CS/HA) composite coating was fabricated by electrophoretic deposition on Ti substrates. Subsequently, the surface morphology, phase composition, wettability, and bonding strength of this composite coating were researched. Additionally, in vitro cytological examination was performed, including evaluations of cell adhesion, cell viability, cell differentiation, cell mineralization, and osteogenetic factor expression. Finally, the in vivo osteogenetic properties were evaluated through an animal study, including a histological analysis, a microcomputed tomography, and biomechanical tests. The results showed that a homogeneous and crack‐free GO/CS/HA composite coating was coated on Ti, and the wettability and bonding strength of the GO/CS/HA composite coating were enhanced compared with HA, GO/HA, and CS/HA coatings. Furthermore, the GO/CS/HA coating greatly heightened the cell–material interactions in vitro. Additionally, this GO/CS/HA‐Ti implant could enhance osseointegration in vivo. Consequently, GO/CS/HA‐Ti may have potential applications in the field of dental implants. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 635–645, 2019.
Developments in electrode design: structure, decoration and applications of electrodes for electrochemical technology
Authors: Walsh Frank C , Arenas Luis F , Ponce de León Carlos 
Published: May 2018

AbstractThe diversity of cell geometries and their use for electrochemical processing and energy conversion are concisely reviewed, updating earlier treatments, with an emphasis on an engineering approach to electrode design. Electrode size varies from several cm2 in the laboratory to stacks containing hundreds of m2 at the industrial plant scale, and currents can range from nA at laboratory to many 100 kA in industry. Electrode materials include metals, conductive ceramics and polymers, as well as polymer–metal or ceramic–metal composites. Area, electrocatalytic activity and functionality can be tailored by selecting an appropriate support structure‐coating combination. The core structure of porous supports can be a foam, mesh or particulate bed, whereas the surface can be enhanced using numerous techniques. Inspiration for electrode design can come from multiple sources, including biomimetics and technology transfer. Important aspects of electrodes include manufacture, electrochemical activity, active area, the possibilities of 3D and nanostructured surfaces, decoration and functionalization, in addition to reasonable cost and adequate lifetime. The diversity of electrodes is illustrated by examples from the authors' laboratory in the fields of inorganic and organic synthesis, environmental remediation of wastewaters, surface finishing of materials and energy storage/conversion. A forward look is made to potential future developments in electrochemical technology. © 2018 Society of Chemical Industry
Platelet indices (mean platelet volume and platelet distribution width) have correlations with periodontal inflamed surface area in coronary artery disease patients: A pilot study
Authors: Temelli Başak , Yetkin Ay Zuhal , Aksoy Fatih , Büyükbayram Halil İbrahim , Kumbul Doğuç Duygu , Uskun Ersin , Varol Ercan 
Published: May 2018

AbstractBackgroundThe plausible mechanisms regarding the relationship between periodontitis and coronary artery disease (CAD) has long been the focus of studies. This study aimed to test the hypothesis that higher periodontal inflamed surface area (PISA) values have positive correlations with increased complete blood parameters in patients with CAD.MethodsPatients who underwent coronary angiography with a suspicion of CAD between the ages 30 to 75 years were included. Clinical periodontal parameters (probing depth [PD], clinical attachment loss, bleeding on probing) were recorded, and the participants were divided into four groups after the coronary angiography: group 1: CAD (+) with periodontitis (n = 20), group 2: CAD (+) without periodontitis (n = 20), group 3: CAD (‐) with periodontitis (n = 21), group 4: CAD (‐) without periodontitis (n = 16). Complete blood counts were analyzed regarding the differences and correlations between the investigated parameters.ResultsCAD (+) P (+) individuals had significantly higher platelet distribution width (PDW) values than the other groups (P < 0.0125). Positive lower correlations were found between PISA scores and mean platelet volume (MPV, P = 0.021, rho = 0.264), PISA and PDW (P = 0.240, rho = 0.036) in the whole study group; and moderate correlation between PD and red blood cell distribution width (RDW, P = 0.049, rho = 0.445) in CAD (‐) groups with/without periodontitis were found. Age was found to predict CAD with o lower OR (1.17, P < 0.01).ConclusionThe results of the present study highlight some blood parameters (PDW, RDW, and MPV) in CAD patients with/without periodontitis in terms of the relationship between inflammatory diseases and their significant low and moderate correlations with PISA values.
Egyptian propolis compared to nanohydroxyapatite graft in the treatment of Class II furcation defects in dogs
Authors: Zohery Amr A. , Meshri Suzanne M. , Madi Marwa I. , Abd El Rehim Samia S. , Nour Zubaida M. 
Published: May 2018

AbstractBackgroundComplementary and alternative medicine approaches are gaining ground in everyday practice. Propolis is a bee product that has been suggested to have bone regenerative effects. This study was conducted to compare the effectiveness of Egyptian propolis with nanohydroxyapatite graft on furcation defect regeneration in mongrel dogs.MethodsA split mouth design was utilized in six clinically healthy mongrel dogs. A total of 24 Class II furcation defects were surgically created in mandibular third and fourth premolars. The defects on the right side were filled with nanohydroxyapatite graft and covered with collagen membrane, while on the left side the defects were filled with propolis and also covered with collagen membrane. The dogs were sacrificed after 1 and 3 months. Segments containing the defects were prepared for histological evaluation.ResultsThe histological evaluation after one month revealed newly formed bone in both treatment groups. However, after 3 months, the bone trabeculae appeared thinner in the collagen/nanohydroxyapatite group than in the collagen/propolis group. The histomorphometric evaluation showed a significant increase in bone height as well as bone surface area for the collagen/propolis group compared to collagen/nanohydroxyapatite group.ConclusionsBoth Egyptian propolis and nanohydroxyapatite graft material showed favorable periodontal regenerative effect. Propolis showed increased cellular proliferative ability that could be beneficial in reducing the healing period needed after periodontal therapy.
Effect of radio‐frequency heating on microbial load, flavor, color, and texture profiles of Cordyceps militaris
Authors: Ma Liang , Zhang Min , Zhao Shuyong 
Published: May 2018

AbstractBACKGROUNDCordyceps militaris is a medicine and food dual‐purpose mushroom extensively cultivated and consumed in East and Southeast Asia for centuries. However, it has an extremely short shelf life of 3–4 days at room temperature. C. militaris was pasteurized for 10, 20, and 30 min by radio‐frequency (RF) at an electrode gap of 20 mm. The effect of RF heating on the microbial load, color, texture, and flavor attributes of C. militaris was evaluated and compared with those sterilized by conventional high‐pressure steam.RESULTSRF heating contributed to good heating uniformity, uniform temperature distribution, and significant decrease in total microbial load. C. militaris heated by RF exhibited unnoticeable total color difference compared with unpasteurized ones, while those sterilized by high‐pressure steam presented undesired and unacceptable browning. Insignificant differences in hardness and chewiness were observed after RF heating. Improvements in mushroom‐like flavor occurred after 10 and 20 min of RF heating.CONCLUSIONThis study suggests that RF heating for pasteurization of edible mushrooms has promising prospects. Evaluation of RF heating on the taste and nutritional characteristics of edible mushrooms is needed in future work. © 2018 Society of Chemical Industry
Characterizations and rheological study of the purified polysaccharide extracted from quince seeds
Authors: Rezagholi Fatemeh , Hashemi Seyed Mohammad Bagher , Gholamhosseinpour Aliakbar , Sherahi Mousa Hamidabadi , Hesarinejad Mohammad Ali , Ale Marcel T 
Published: May 2018

AbstractBACKGROUNDThe functional characteristics of hydrocolloids are mainly dependent on their physicochemical properties. Thus, it is essential to characterize the new sources of hydrocolloids.RESULTSQuince seed gum (QSG) is a high‐molecular‐weight polysaccharide (9.61 × 106 g mol−1) composed of 85.04 ± 2.87% carbohydrate (6.39% l‐arabinose, 40.43% d‐xylose, 5.60% d‐galactose, 5.75% d‐glucose and 31.11% d‐mannose), 13.16 ± 1.73% uronic acid, 5.77 ± 0.83% moisture, 2.78 ± 0.21% protein, 5.64 ± 0.21% ash, and 0.75 ± 0.09% fat. Our findings indicated that this gum could be introduced as a value‐added by‐product in the food and pharmaceutical industries. Carbon‐13 nuclear magnetic resonance and Fourier transform infrared spectroscopy suggested a highly substituted xylan structure for QSG. In the dilute regime, an increase in the ion concentration was accompanied by a decrease in intrinsic viscosity of QSG. When the salt concentration increased from 0 to 50 mmol L−1, the consistency coefficient (as a measure of apparent viscosity) declined. On the other hand, with further increasing of salt concentration, the consistency coefficient (as a measure of apparent viscosity) values increased. Similarly, the G′ and G″ values for 10 and 50 mmol L−1 calcium chloride concentrations were less than in control samples.CONCLUSIONThe rheological behavior of the QSG studied in this paper can provide insight into its potential application in food and pharmaceutical industries. © 2018 Society of Chemical Industry
Study of the Ultrasound Appearance of the Normal Parathyroid Using an Intraoperative Procedure
Authors: Xia Chunxia , Zhu Qiang , Li Zheng , Hu Minxia , Fang Jugao , Zhong Qi , Yue Changli , Bai Yuping 
Published: May 2018

ObjectivesThis study was designed to confirm the echogenicity of normal parathyroid glands using intraoperative ultrasound (US).MethodsBetween October 2015 and January 2016, normal parathyroid glands were examined with an intraoperative US transducer during thyroidectomy procedures in 13 patients with thyroid disease. According to the findings from intraoperative US, routine percutaneous US of normal parathyroid glands was performed in a group of adults. On the basis of previous information on normal parathyroid echogenicity, a series of parathyroid diseases that were proved by surgery and histopathologic analyses were retrospectively reviewed. The presence of residual normal parathyroid in the lesion on US imaging, which was defined as the residual parathyroid sign in this study, was reviewed and correlated with histopathologic results.ResultsIn the intraoperative US group, 23 parathyroid glands were scanned intraoperatively, and 21 (91.3%) were hyperechoic, homogeneous in texture, and oval. In the routine percutaneous US group, 106 parathyroid glands were found in total, and 96 (90.5%) of the glands had hyperechoic and homogeneous echogenicity, with 75 (70.8%) being oval. In the review of parathyroid diseases, 33 parathyroid glands in 30 cases were reviewed, with a positive residual parathyroid sign in 7 (21.2%) parathyroid glands, presenting with a hyperechoic rim in the margin, and 4 of them (12.1%) were confirmed by histopathologic results.ConclusionsThe normal parathyroid had hyperechoic echogenicity on both intraoperative and percutaneous US imaging. Residual tissue of parathyroid glands can also be observed in some parathyroid abnormalities with an echogenic appearance on US imaging and confirmed by histopathologic results.
Adhesion of gram‐negative rod‐shaped bacteria on 1D nano‐ripple glass pattern in weak magnetic fields
Authors: Saleem Iram , Masood Samina , Smith Derek , Chu Wei‐Kan 
Published: May 2018

AbstractThis research project has major applications in the healthcare and biomedical industries. Bacteria reside in human bodies and play an integral role in the mechanism of life. However, their excessive growth or the invasion of similar agents can be dangerous and may cause fatal or incurable diseases. On the other hand, increased exposure to electromagnetic radiation and its impact on health and safety is a common concern to medical science. Some nanostructure materials have interesting properties regarding facilitating or impeding cell growth. An understanding of these phenomena can be utilized to establish the optimum benefit of these structures in healthcare and medical research. We focus on the commonly found rod‐shaped, gram‐negative bacteria and their orientation and community development on the cellular level in the presence of weak magnetic fields on one dimensional nano‐ripple glass patterns to investigate the impact of nanostructures on the growth pattern of bacteria. The change in bacterial behavior on nanostructures and the impact of magnetic fields will open up new venues in the utilization of nanostructures. It is noticed that bacterial entrapment in nano‐grooves leads to the growth of larger colonies on the nanostructures, whereas magnetic fields reduce the size of colonies and suppress their growth.
6‐Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP‐1‐Derived Macrophages
Authors: Wang Dongdong , Hiebl Verena , Ladurner Angela , Latkolik Simone L. , Bucar Franz , Heiß Elke H. , Dirsch Verena M. , Atanasov Atanas G. 
Published: May 2018

ScopeGinger is reported to be used for the prevention and treatment of cardiovascular diseases (CVD). Cholesterol efflux from macrophage foam cells is an important process in reverse cholesterol transport, whose increase may help to prevent or treat CVD. In this study, we investigated the effects of 6‐dihydroparadol from ginger on macrophage cholesterol efflux.Methods and resultsWe show that 6‐dihydroparadol concentration‐dependently enhances both apolipoprotein A1‐ and human plasma–mediated cholesterol efflux from cholesterol‐loaded THP‐1‐derived macrophages using macrophage cholesterol efflux assay. 6‐Dihydroparadol increases protein levels of both ATP‐binding cassette transporters A1 and G1 (ATP‐binding cassette transporter A1 [ABCA1] and ATP‐binding cassette transporter G1 [ABCG1]) according to Western blot analysis. The ABCA1 inhibitor probucol completely abolishes 6‐dihydroparadol‐enhanced cholesterol efflux. Furthermore, increased ABCA1 protein levels in the presence of 6‐dihydroparadol were associated with both increased ABCA1 mRNA levels and increased ABCA1 protein stability. Enhanced ABCG1 protein levels were only associated with increased protein stability. Increased ABCA1 protein stability appeared to be the result of a reduced proteasomal degradation of the transporter in the presence of 6‐dihydroparadol.ConclusionWe identified 6‐dihydroparadol from ginger as a novel promoter of cholesterol efflux from macrophages that increases both ABCA1 and ABCG1 protein abundance. This newly identified bioactivity might contribute to the antiatherogenic effects of ginger.