bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluctuation of magnitude of wave loads for a long array of bottom-mounted cylinders
Authors: Zeng Xiaohui , Yu Fajun , Shi Min , Wang Qi 
Published: April 2019

For wave loads on cylinders constituting a long but finite array in the presence of incident waves, variations in the magnitude of the load with the non-dimensional wavenumber exhibit interesting features. Towering spikes and nearby secondary peaks (troughs) associated with trapped modes have been studied extensively. Larger non-trapped regions other than these two are termed Region III in this study. Studies of Region III are rare. We find that fluctuations in Region III are regular; the horizontal distance between two adjacent local maximum/minimum points, termed fluctuation spacing, is constant and does not change with non-dimensional wavenumbers. Fluctuation spacing is related only to the total number of cylinders in the array, identification serial number of the cylinder concerned and wave incidence angle. Based on the interaction theory and constructive/destructive interference, we demonstrate that the fluctuation characteristics can be predicted using simple analytical formulae. The formulae for predicting fluctuation spacing and the abscissae of every peak and trough in Region III are proposed. We reveal the intrinsic mechanism of the fluctuation phenomenon. When the diffraction waves emitted from the cylinders at the ends of the array and the cylinder concerned interfere constructively/destructively, peaks/troughs are formed. The fluctuation phenomenon in Region III is related to solutions of inhomogeneous equations. By contrast, spikes and secondary peaks are associated with solutions of the eigenvalue problem. This study of Region III complements existing understanding of the characteristics of the magnitude of wave load. The engineering significances of the results are discussed as well.
Liability of Middleness Revisited: The Advantages for Mid-Sized Competitors in Renewable Natural Resource Industries
Authors: Cruz Alfonso , Reyes Tomas , Vassolo Roberto 
Published: April 2019

ABSTRACTSize is an important antecedent of firm survival, and several studies theoretically sustain and empirically support a ‘liability of middleness’. Indeed, it is widely believed that companies should act strategically to either become large or remain small and occupy a niche position, because mid-sized firms face the strongest market selection pressures. This study challenges that logic in renewable natural resource industries. Measuring size as product-line scale and firm-level portfolio breadth, we argue that in industries characterized by cost competition, the lack of product differentiation, large capital investments, and sharp price oscillation, scale and breadth have a curvilinear effect on survival thatfavorsmid-sized firms rather than penalizing them. An empirical analysis of the US pulp and paper (P&P) industry over the period 1970–2000 strongly supports our arguments. This study is particularly relevant for emerging economies, in which natural resource industries represent an important portion of the total economic activity.
Continued State Liability for Police Inaction in Assisting Victims of Domestic Violence: A Reflection on the Implementation of South Africa's Domestic Violence Legislation
Authors: Spies Amanda 
Published: April 2019

AbstractNow that it has been in operation for 20 years, it is necessary to reflect on the impact the South African Domestic Violence Act has had on women's lives. This article analyses this key legislation and the police's duty to ensure its proper implementation. It focuses on the reports of the Independent Complaints Directorate and Civilian Secretariat of Police, the bodies responsible for measuring police compliance with the act. The reports identify serious transgressions, highlighting the police's perception that domestic violence is a private affair with which it should not interfere. This perception plays a particularly subtle and destructive role in legitimizing, supporting and permitting violence against women. In focusing on key court decisions in which the state (police) was held financially accountable for the failure to protect women against violence, the author highlights the importance of challenging the social and legal understanding of women's experiences with violence in promoting a system that takes account of those experiences.
Are pioneering coyotes, foxes and jackals alien species? Canid colonists in the changing conservation landscape of the Anthropocene
Authors: Somsen Han , Trouwborst Arie 
Published: April 2019

AbstractThe pervasive influence of human agency on biodiversity in the Anthropocene gives rise to several new challenges for national and international wildlife law, including questions regarding what is natural and what is alien. Ultimately, a new vision and new rules are called for but in the meantime wildlife lawyers and other conservation professionals must work with conventional legal frameworks. Striking instances where vexing issues arise are the recent range expansions of certain canids. Coyotes Canis latrans and crab-eating foxes Cerdocyon thous in the Americas and golden jackals Canis aureus in Europe are progressively colonizing areas and countries where they did not previously occur. A key question is whether to consider this as acceptable extensions of natural range or whether the pioneering carnivores should be viewed as alien species, potentially triggering legal obligations of prevention, control and eradication. In addressing this question we draw on guidance provided under the Convention on Biological Diversity and other international legal frameworks, in which governments are forced to grapple with the application of long-standing concepts to new phenomena in an era of profound global change. Our analysis suggests that coyotes in Costa Rica, crab-eating foxes in Panama, and golden jackals in the Netherlands are not to be considered alien species, whether invasive or not. Thus, even if action to address adverse impacts by these canids on native biodiversity may sometimes be desirable, these species are not subject to legal requirements to combat invasive alien species.
A spatio-legal approach to the intermediate housing-with-care solutions for older people: exploring the adoption of a retirement village concept in Finland
Authors: Lundman Riina 
Published: April 2019

AbstractRetirement villages are an increasingly popular senior housing option that aims to comprehensively integrate accommodation, care services, social activities and interaction opportunities for ageing people. The research literature about retirement villages and communities is extensive, but less studied are the contextually varying spatial, legal and political processes of how such villages and other intermediate housing-with-care solutions for older people are initially constituted, especially in novel national and local contexts. In this paper, a spatio-legal approach is employed to study the many legal possibilities and barriers that have arisen while developing retirement villages in Finland. As a specific case, I examine the new Finnish Virkkulankylä retirement village concept and its implementation process. As the key result of my study, I identify three major spatio-legal barriers to developing retirement villages and other intermediate senior housing solutions, which are (a) the polarised division between the fields of elderly care and housing in both law and practice, (b) the prevalence of ‘local law’ in spatial planning and service provision for elderly people, and (c) the inflexible funding system regarding alternative housing-with-care solutions for seniors. I argue that although the ‘in-betweenness’ of retirement villages may facilitate a more comprehensive understanding about the housing and care of older adults, in practice their intermediary position translates into many ambiguities and challenges.
RESIDENTIAL BURIAL ALONG THE SOUTHERN STREET OF THE DEAD: SKELETONS AND ISOTOPES
Authors: Storey Rebecca , Buckley Gina M. , Kennett Douglas J. 
Published: April 2019

AbstractSkeletal remains from Tlajinga 33 (33:S3W1) have been the focus of research in the southern sector of Teotihuacan since excavations took place in the 1980s. Recent excavations in Tlajinga Compounds 17 and 18 (17:S3E1 and 18:S3E1, respectively), located along the southern Street of the Dead, recovered nine additional skeletons. This article is a description of the burials from Compounds 17 and 18 and a comparative analysis of health, diet, and chronology across all three compounds (Compounds 17, 18, and 33). Here, we test the hypothesis that individuals between residential compounds at Tlajinga lived similar lives and that health and biogeochemical markers of individuals will reflect these similarities. Although the sample size is small, the paleopathological analysis of individuals at Compounds 17 and 18 indicates morbidity patterns similar to Tlajinga 33, but also that these residents were perhaps less susceptible to stressors during periods of juvenile growth. Stable carbon and nitrogen isotopes suggest that, overall, diets were analogous across compounds, but Compounds 17 and 18 were able to supplement their diet with a greater variety of plant resources. There were no clear dietary differences between higher and lower status individuals, however. Finally, accelerated mass spectrometry radiocarbon (AMS14C) dates indicate that residential living may have occurred later at Compound 18 than at Compound 17 and Tlajinga 33.
NEW RESEARCH AT TEOTIHUACAN’S TLAJINGA DISTRICT, 2012–2015
Authors: Carballo David M. , Hirth Kenneth G. , Hernández Sariñana Daniela , Buckley Gina M. , Mejía Ramón Andrés G. , Kennett Douglas J. 
Published: April 2019

AbstractTeotihuacan's Tlajinga district is a cluster of neighborhoods on the southern periphery of the city best known for earlier investigations at Compound 33:S3W1. New research includes excavations at two other apartment compounds and along the southern extension of the Street of the Dead. Excavation contexts, major finds, chronology, and preliminary interpretations are the subject of this article. We highlight evidence attesting to a major obsidian-blade workshop at Compound 17:S3E1, offerings, and other features at that compound and Compound 18:S3E1, and the tempo and processes of urbanization viewed through well-recorded stratigraphic sequences of the compounds and the Street of the Dead. We conclude that significant occupation began in the Miccaotli phase, but it was not until some point in the Early Tlamimilolpa phase that the dominant housing type became apartment compounds; the continuation of the axis of Street of the Dead in the district was accomplished by excavating in the volcanic tuft substrate (tepetate) and could have been undertaken by the inhabitants of the district themselves; and the presence of items such as a sculpted stone face, marine shell, and polychrome pottery demonstrates that commoners at Teotihuacan enjoyed some access to finer items within the interregional economy.
The prognostic value of balloon occlusion in candidates for the various types of cavo-pulmonary anastomosis
Authors: Kusa Jacek , Bermúdez-Cañete Ramón , Herraiz Ignacio , Bialkowski Jacek , Szkutnik Malgorzata , Pilar Díaz Maria , Villagra Fernando , Antonio Sanchez Pedro 
Published: April 2019

The purpose of our paper is to assess the prognostic value of balloon occlusion as a test for patients with various types of functionally single ventricle after different palliative surgical procedures who were candidates for further modifications of a cavo-pulmonary operation. In all patients, there were at least two sources of pulmonary arterial supply.Our hypothesis was that, using balloon occlusion temporarily to produce changes in the haemodynamic situation, we could simulate the potential state subsequent to surgical palliation. We used balloon occlusion in 19 patients during diagnostic catheterisation, followed by interventional and or surgical procedures as considered necessary. This test was applied for temporary closure of the pulmonary valve in 8 patients, and a Blalock-Taussig anastomosis in 11 patients.
Microstructural Characterization by Automated Crystal Orientation and Phase Mapping by Precession Electron Diffraction in TEM: Application to Hot Deformation of a γ-TiAl-based Alloy
Authors: Singh Vajinder , Mondal Chandan , Bhattacharjee P. P. , Ghosal P. 
Published: April 2019

AbstractMicrostructural evolution of a hot deformed γ-TiAl-based Ti–45Al–8Nb–2Cr–0.2B (at.%) alloy has been studied using an advanced characterization technique called automated crystal orientation and phase mapping by precession electron diffraction carried out in a transmission electron microscope (with a NanoMEGAS attachment). It has been observed that the technique, having a capability to recognize diffraction patterns with improved accuracy and reliability, is particularly suitable for characterization of complex microstructural features evolved during hot deformation of multiphase (α2 + γ + β)-based TiAl alloys. Examples of coupled orientations and phase maps of the present alloy demonstrate that the accurate reproduction of the very fine lamellar structure (α2 + γ + γ) is feasible due to its inherent high-spatial resolution and absence of a pseudo-symmetry effect. It enables identification of salient features of γ-TiAl deformation behavior in terms of misorientation analyses (GAM, GOS, and KAM) and transformation characteristics of very fine lamellar constituent phases. Apart from conventional strain analyses from the orientation database, an attempt has been made to image the dislocation sub-structure of γ-phases, which supplements the deformation structure evaluation using this new technique.
Does managed competition constrain hospitals' contract prices? Evidence from the Netherlands
Authors: Douven Rudy , Burger Monique , Schut Frederik 
Published: April 2019

AbstractIn the Dutch health care system, health insurers negotiate with hospitals about the pricing of hospital products in a managed competition framework. In this paper, we study these contract prices that became for the first time publicly available in 2016. The data show substantive price variation between hospitals for the same products, and within a hospital for the same product across insurers. About 27% of the contract prices for a hospital product are at least 20% higher or lower than the average contract price in the market. For about half of the products, the highest and the lowest contract prices across hospitals differ by a factor of three or more. Moreover, hospital product prices do not follow a consistent ranking across hospitals, suggesting substantial cross-subsidization between hospital products. Potential explanations for the large and seemingly random price variation are: (i) different cost pricing methods used by hospitals, (ii) uncertainty due to frequent changes in the hospital payment system, (iii) price adjustments related to negotiated lumpsum payments and (iv) differences in hospital and insurer market power. Several policy options are discussed to reduce variation and increase transparency of hospital prices.
The Fundamental Aerosol Models Over China Region: A Cluster Analysis of the Ground‐Based Remote Sensing Measurements of Total Columnar Atmosphere
Authors: Li Zhengqiang , Zhang Ying , Xu Hua , Li Kaitao , Dubovik Oleg , Goloub Philippe 
Published: April 2019

AbstractTen fundamental aerosol models in China are derived from a cluster study based on the ground‐based remote sensing measurements of Sun‐sky radiometer Observation NETwork. The aerosol size distribution decomposition techniques are employed to yield individual fine and coarse mode size distribution functions with independent refractive indices. The total 10,773 records containing 18 kinds of aerosol microphysical parameters are used to yield 10 typical clusters with the verification of clustering robustness. Ten clusters suggest five typical fine particle aerosol models including urban polluted, secondary polluted, combined polluted, polluted fly ash, and continental background, as well as five coarse models including summer fly ash, winter fly ash, primary dust, transported dust, and background dust over China region. The representativeness and coappearance analyses again reveal five dominative aerosol patterns on the base of fundamental models. These models can be used in the chemical model simulation, satellite remote sensing, climate, and environment analyses.
Measuring endogenous changes in serotonergic neurotransmission with [11C]Cimbi-36 positron emission tomography in humans
Authors: da Cunha-Bang Sofi , Ettrup Anders , Mc Mahon Brenda , Skibsted Anine Persson , Schain Martin , Lehel Szabolcs , Dyssegaard Agnete , Jørgensen Louise Møller , Møller Kirsten , Gillings Nic , Svarer Claus , Knudsen Gitte M. 
Published: April 2019

AbstractDeveloping positron emission tomography (PET) radioligands for the detection of endogenous serotonin release will enable the investigation of serotonergic deficits in many neuropsychiatric disorders. The present study investigates how acute challenges that aim to increase or decrease cerebral serotonin levels affect binding of the serotonin 2A receptor (5-HT2AR) agonist radioligand [11C]Cimbi-36. In a randomized, double-blind, placebo-controlled, three-arm design, 23 healthy volunteers were PET scanned twice with [11C]Cimbi-36: at baseline and following double-blind assignment to one of three interventions (1) infusion of the selective serotonin reuptake inhibitor (SSRI) citalopram preceded by oral dosing of the 5-HT1AR antagonist pindolol, (n = 8) (2) acute tryptophan depletion (ATD) (n = 7) and (3) placebo (n = 8). Two-sample t-tests revealed no significant group differences in percent change of neocortical [11C]Cimbi-36 binding from baseline to intervention between placebo and citalopram/pindolol (p = 0.4) or between placebo and ATD (p = 0.5). Notably, there was a significantly larger within-group variation in 5-HT2AR binding after intervention with citalopram/pindolol, as compared with placebo (p = 0.007). These findings suggest that neither ATD nor a combination of citalopram and pindolol elicit acute unidirectional changes in serotonin levels sufficient to be detected with [11C]Cimbi-36 PET in neocortex. We suggest that the large interindividual variation in 5-HT2AR binding after citalopram/pindolol reflects that after an acute SSRI intervention, individuals respond substantially different in terms of their brain serotonin levels. Our observation has a potential impact for the understanding of patient responses to SSRI.
Public Dental Service personnel facing a major health care reform in Finland
Authors: Widström Eeva , Tiira Hannele , Tillberg Anders 
Published: April 2019

Abstract
Objectives
A health care reform will replace the health care and social services centred on public provision with a market-oriented system and enhanced competition between public and private sectors. The aim was to ascertain Public Dental Services (PDS) changes personnel anticipated and how dental services in the new “public” undertakings could be made more cost-efficient.

Materials and methods
An electronic questionnaire was sent to the Chief Dentists of a random sample of 12 PDS units in southern and northern Finland for distribution to their personnel; 71.0% responded.

Results
Most respondents (64.3%) believed that their PDS unit would not change. However, 45.4% foresaw a merger with another unit. More dentists (51.2%) were aware of market- and competition-oriented organisational forms to be introduced in the public sector than dental hygienists (35.0%) and dental assistants (27.3%; p < 0.01). Only 12.4% thought of moving to the private sector. To increase cost-efficiency in the new system, a majority suggested improvement in preventive care (79.8%) and increased use of dental hygienists (75.7%). A smaller proportion suggested longer opening hours (23.1%), higher patient fees (17.9%) or more paying patients (12.4%).

Discussion
Public sector employees had little knowledge and understanding of the coming reform and were badly prepared for competition with the private sector.
Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure
Authors: Zhang Jitai , An Hui , Ni Kaidi , Chen Bin , Li Hui , Li Yanqin , Sheng Guilian , Zhou Chuanzan , Xie Mengzhen , Chen Saijing , Zhou Tong , Yang Gaoxiong , Chen Xiufang , Wu Gaojun , Jin Shengwei , Li Ming 
Published: April 2019

AbstractModern lifestyles have altered diet and metabolic homeostasis, with increased sugar intake, glycemic index, and prediabetes. A strong positive correlation between sugar consumption and diabetic incidence is revealed, but the underlying mechanisms remain obscure. Here we show that oral intake of long-term oscillating glucose (LOsG) (4 times/day) for 38 days, which produces physiological glycemic variability in rats, can lead to β-cells gaining metabolic memory in reactive oxygen species (ROS) stress. This stress leads to suppression of forkhead box O1 (FoxO1) signaling and subsequent upregulation of thioredoxin interacting protein, inhibition of insulin and SOD-2 expression, re-expression of Neurog3, and β-cell dedifferentiation and functional failure. LOsG-treated animals develop prediabetes exhibiting hypoinsulinemia and glucose intolerance. Dynamic and timely administration of antioxidant glutathione prevents LOsG/ROS-induced β-cell failure and prediabetes. We propose that ROS stress is the initial step in LOsG-inducing prediabetes. Manipulating glutathione-related pathways may offer novel options for preventing the occurrence and development of diabetes.
Diverse small molecules prevent macrophage lysis during pyroptosis
Authors: Loomis Wendy P. , den Hartigh Andreas B. , Cookson Brad T. , Fink Susan L. 
Published: April 2019

AbstractPyroptosis is a programmed process of proinflammatory cell death mediated by caspase-1-related proteases that cleave the pore-forming protein, gasdermin D, causing cell lysis and release of inflammatory intracellular contents. The amino acid glycine prevents pyroptotic lysis via unknown mechanisms, without affecting caspase-1 activation or pore formation. Pyroptosis plays a critical role in diverse inflammatory diseases, including sepsis. Septic lethality is prevented by glycine treatment, suggesting that glycine-mediated cytoprotection may provide therapeutic benefit. In this study, we systematically examined a panel of small molecules, structurally related to glycine, for their ability to prevent pyroptotic lysis. We found a requirement for the carboxyl group, and limited tolerance for larger amino groups and substitution of the hydrogen R group. Glycine is an agonist for the neuronal glycine receptor, which acts as a ligand-gated chloride channel. The array of cytoprotective small molecules we identified resembles that of known glycine receptor modulators. However, using genetically deficient Glrb mutant macrophages, we found that the glycine receptor is not required for pyroptotic cytoprotection. Furthermore, protection against pyroptotic lysis is independent of extracellular chloride conductance, arguing against an effect mediated by ligand-gated chloride channels. Finally, we conducted a small-scale, hypothesis-driven small-molecule screen and identified unexpected ion channel modulators that prevent pyroptotic lysis with increased potency compared to glycine. Together, these findings demonstrate that pyroptotic lysis can be pharmacologically modulated and pave the way toward identification of therapeutic strategies for pathologic conditions associated with pyroptosis.