bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness of Hepatitis A vaccination in a developed and developing country
Authors: Ghildayal Nidhi 
Published: September 2019

Purpose
Hepatitis A is a prevalent disease that is largely preventable by vaccine usage. The vaccine for this illness is highly underused in most regions. In an attempt to find the strategies that are most beneficial in regard to quality-adjusted life years (QALYs) and cost in current environments, the purpose of this paper is to conduct cost-effectiveness analyses to investigate vaccination strategies in a more economically developed country (MEDC), generally known as a “developed” area: the USA, and a less economically developed country (LEDC), generally known as a “developing” area: the state of Rio de Janeiro, Brazil.

Design/methodology/approach
This study used a dynamic transmission model for comparative effectiveness analyses. The model ran two different scenarios. The two regions studied have different policies and strategies for Hepatitis A vaccination currently, and also used different strategies in 2009. In the USA, a universal vaccination policy was modeled, along with a scenario in which it was removed. In Rio de Janeiro, a no vaccination policy was modeled, along with a scenario in which a universal vaccination policy was effected.

Findings
The comparison of resulting incremental cost-effectiveness ratio values to accepted threshold values showed universal vaccination to be cost-effective in both the USA and Rio de Janeiro as compared to no vaccination. When episode and vaccination costs and vaccination efficacy were varied, this still remained true. Universal vaccination was found to result in lower incidence of Hepatitis A in both the USA and Rio de Janeiro. Over the twenty-year time horizon, universal vaccination is projected to prevent 506,945 cases of symptomatic Hepatitis A in the USA and 42,318 cases of Hepatitis A in Rio de Janeiro. Other benefits include a projected increase in cumulative QALYs through the use of universal vaccination.

Originality/value
This analysis showed universal vaccination to be cost-effective as compared to no vaccination, and portions of the study’s approach had not previously been applied in tandem to investigate Hepatitis A interventions. The results may help foster higher compliance rates for Hepatitis A vaccination and even greater per-person economic benefits of universal vaccination, particularly in the USA. The purpose of this study is also to encourage elevated levels of surveillance on age of infection in developing regions and consistent reevaluation utilizing dynamic transmission models in both the USA and Brazil, as well as other rapidly developing regions, in order to prevent future epidemics and costs associated with the disease.
Interest-free microfinance in India: a case study of Bait-un-Nasr Urban Cooperative Credit Society
Authors: Shaik Mohammed Wasiullah , Waheed Khalid 
Published: October 2019

Purpose
The purpose of this paper is to understand interest-free microfinance practices in India, identify issues and recommend possible solutions.

Design/methodology/approach
To achieve the proposed objectives, Bait-un-Nasr (BuN) Urban Cooperative Credit Society, located in Mumbai, India, is considered for the case study. The study is based on both primary and secondary data. The primary data are collected through questionnaires and secondary data from various sources. Performance of the institution is assessed in terms of growth and sustainability indicators.

Findings
It is found that BuN has been successful in providing interest-free microfinance services in India. A few operational issues have been highlighted and possible solutions are recommended. Moreover, it is found that in comparison to the microfinance industry standards, the performance of BuN has been lower.

Research limitations/implications
BuN is evaluated from only growth and sustainability aspects and not from the aspect of the socio-economic impacts of its services on the lives of customers.

Practical implications
This study would become a documented source of interest-free microfinance practices in India. Moreover, the recommendations provided, if implemented, would help BuN in further growth and development.

Social implications
This study would help create awareness in the society about the practices of interest-free microfinance.

Originality/value
This paper highlights the interest-free microfinance practices in India that have not received the needed attention. The paper also attempts to identify key issues pertaining to interest-free microfinance with possible solutions.
Alternatives for airport management in Brazil
Authors: da Costa Vitor Augusto Martins , Ribeiro Danielle Carvalho 
Published: September 2019

Purpose
This paper aims to answer the following question: Is PPP a financially viable alternative for the management of regional airports in Brazil?

Design/methodology/approach
The methodology is based on the case study of the innovative model of Zona da Mata Regional Airport management. It was used Value for Money as a method to compare this case with the conventional airport management alternative.

Findings
It was observed that, when compared to the airport management alternative through contracting third parties, the public–private partnership (PPP) provided a reduction of almost 70% of public spending on the management of this infrastructure. Besides the financial advantage, other benefits of this PPP contract were also observed.

Research limitations/implications
The analyses carried out in this study are not exhaustive and can be improved and remade as the life cycle of the PPP contract studied is progressed.

Practical implications
It was concluded, from the results found, that PPP is an efficient alternative for the management of regional airports in Brazil, and the model can be replicated for similar airports.

Originality/value
When analyzing the results of this innovative project of managing a regional airport through a PPP, this work made it possible to measure the positive impacts of this alternative and demonstrate the potential of the PPP as an alternative for the management of other regional airports in Brazil.
Religiosity level and saving decisions in Baitul Maal wat Tamwil: the case of Indonesia
Authors: Wijaya Ibrahim Fatwa , Hakim Arif Rahman , Saputro Nugroho , Mulyadi Mulyadi 
Published: October 2019

Purpose
This paper aims to examine the relationship between religiosity level and reasons for saving money in Islamic microfinance institutions [Baitul Maal wat Tamwil (BMT)] in Surakarta and Sukoharjo, Indonesia.

Design/methodology/approach
A chi-square test was used to identify the relationship between religiosity level and saving decisions in BMTs. In addition, the authors tested religiosity level and the reasons for transactions in both BMTs and conventional banking. Data were collected via a questionnaire. A total of 523 respondents from Surakarta and Sukoharjo, Indonesia, participated in the survey. The respondents are customers of 31 BMTs in Surakarta and Sukoharjo.

Findings
The authors find a significant relationship between one’s religiosity and the reason for saving money in BMTs. Products that are in accordance with Islamic principles form the highest reason for saving money in BMTs, followed by quality of service, recommendation from friends and location. In addition, purpose of business is the main reason for transactions in both BMTs and conventional banking. However, there is no significant relationship between religiosity level and the decision to transact in both BMTs and conventional banking.

Originality/value
There is a lack of literature discussing Islamic microfinance institutions, especially in Indonesia. Furthermore, BMT customers have different characteristics compared with those of large banks.
The role of consumer-brand engagement towards driving brand loyalty
Authors: Adhikari Kishalay , Panda Rajeev Kumar 
Published: October 2019

Purpose
The present research attempts to empirically examine the influence of consumer-brand engagement, its potent antecedents, and relationship quality towards creating and enhancing brand loyalty of automobile brands in Indian context.

Design/methodology/approach
Primary data through survey questionnaires were used to gather empirical data from 443 automobile consumers, out of which 417 samples were included in the final analysis. Structural equation modelling technique was used for assessing the hypothesized direct and indirect relationships among the constructs.

Findings
The empirical findings exhibit consumer involvement and brand interactivity contributes positively and significantly towards consumer-brand engagement, while self-brand image congruity does not significantly influence consumer-brand engagement. Further, mediation analysis results show that relationship quality partially mediates the linkage between consumer-brand engagement and brand loyalty.

Research limitations/implications
The outcomes of this research may provide novel insights and contribute to the limited body of knowledge regarding consumer-brand engagement. In addition, the findings may assist the automobile brand managers and market strategists to design strategies aimed at developing long-term consumer relationships.

Originality/value
This empirical research assesses the mediating effect of relationship quality in the linkage between consumer-brand engagement and brand loyalty for automobile brands, and to the best of our knowledge, has not been attempted by prior researchers in this domain.
Life‐history trade‐offs and senescence in plants
Authors: Roach Deborah A. , Smith Erin F. 
Published: October 2019

Abstract

An increasing number of studies have shown that senescence, the functional decline in traits and increased risk of mortality with increasing age, occurs in organisms in wild populations, but there is a wide range of diversity in the patterns of senescence across species.

The antagonistic pleiotropy and the disposable soma theories of senescence predict that there will be life‐history trade‐offs between performance at early‐ and late‐life stages. Plants show variation in senescence patterns and thus provide an opportunity to evaluate life‐history trade‐offs and senescence. Many plant species can be easily followed demographically and their environments, resources and allocation to reproduction can be manipulated, which makes them particularly good models to address these questions.

We compared the results from 22 studies of plant senescence in the wild and compiled 20 examples of life‐history trade‐offs in plants. Some of the unique features of plants that may influence senescence patterns and trade‐offs in the wild are highlighted through the results.

We found all three age‐specific patterns: age decline, age improvement and no change with age for plants in the wild. Most species showed an age‐dependent decline in at least one trait but, even within a species, the age‐specific patterns of traits varied. Results also showed that trade‐offs vary across environments and that plants can manipulate their resource pool through increases in photosynthesis, which will influence the manifestation of trade‐offs.

We conclude that aspects of plant biology including dynamic resource pools, the impact of size, dormancy and below‐ground storage may influence both the patterns of senescence and life‐history trade‐offs. The diversity of plant life forms and life cycles provide a wealth of opportunities to experimentally study senescence in the context of life‐history trade‐offs.

A free Plain Language Summary can be found within the Supporting Information of this article.
ABCB1 polymorphism predicts the toxicity and clinical outcome of lung cancer patients with taxane‐based chemotherapy
Authors: Zhong Jia , Guo Zihan , Fan Liping , Zhao Xinghui , Zhao Bingqing , Cao Zhigang , Cheng Linlin , Shi Yuanyuan , Li Xiaoting , Zhang Yanhua , An Tongtong , Wu Meina , Wang Yuyan , Zhuo Minglei , Li Jianjie , Yang Xue , Chen Hanxiao , Jia Bo , Zhao Jun 
Published: October 2019

BackgroundTaxane‐based chemotherapy is widely used in lung cancer. ABCB1 have a role in the prediction of treatment response and toxicity of chemotherapy in solid tumors. In this retrospective study, we investigated ABCB1 polymorphism on response and toxicity in taxane‐based chemotherapy in lung cancer patients.MethodsA total of 122 lung cancer patients who received taxane‐based chemotherapy were included in this study. Fluorescence in situ hybridization (FISH) was used for ABCB1 polymorphism detection. Turbidimetric inhibition immunoassay was used for pharmacokinetic analysis. Statistical analysis was performed using SPSS 20.0.ResultsThe frequency of the ABCB1 2677 site TT/TG/GG genotype was 32.8%, 43.4% and 23.8%, respectively and the frequency of the 3435 sites the TT/TC/CC genotype was 13.9%, 44.3% and 41.8%, respectively. The occurrence of neurotoxicity was higher in patients who had ABCB1 3435 site mutation (TT 88.2%, TC 22.2%, CC 21.6% P = 0.004). There was no significant difference between ABCB1 genotypes with regard to other chemotherapy‐induced toxicity. For non‐small cell lung cancer (NSCLC) patients, those harboring ABCB1 2677 and 3435 site wild‐type patients had longer median progression‐free survival (PFS) in the paclitaxel subgroup (3435 site: TT 3.87 vs. TC 9.50 vs. CC 14.13 months; P < 0.001; 2677 site: TT 4.37 vs. TG 9.73 vs. GG 12.1 months; P = 0.013). The area under the concentration‐time curve (AUC) of 20 patients treated with docetaxel increased for ABCB1 mutation subgroups.ConclusionABCB1 mutation is associated with higher neurotoxicity of taxane‐based chemotherapy. It also predicts shorter PFS for NSCLC in paclitaxel‐based treatment.
Aerobic interval training in standard treatment of out‐patients with schizophrenia: a randomized controlled trial
Authors: Brobakken M. F. , Nygård M. , Güzey I. C. , Morken G. , Reitan S. K. , Heggelund J. , Wang E. , Vedul‐Kjelsaas E. 
Published: September 2019

ObjectiveTo evaluate the feasibility and effects of integrating aerobic interval training (AIT) in standard care of out‐patients with schizophrenia on aerobic capacity and conventional cardiovascular disease (CVD) risk factors.MethodsOut‐patients with schizophrenia spectrum disorder were randomized to the following: 1) a training group (TG), performing AIT 2 day/week at the clinic with adherence support from municipal services; or 2) a control group (CG), given two AIT sessions and encouraged to exercise on their own. Feasibility was assessed through retention/adherence. was measured directly along with conventional CVD risk factors before and after 12 weeks.ResultsOf 48 out‐patients, 16/25 and 18/23 completed the TG and CG respectively. After 12 weeks, was higher (2.7 ± 4.8 ml/kg/min, P < 0.01) in the TG compared with the CG. The TG improved by 3.1 ± 3.7 ml/kg/min (P < 0.01), while no change in the CG was observed. No intergroup difference in weight, body mass index (BMI), waist circumference, blood pressure, lipids, or glucose at posttest was observed. Weight (1.9 ± 4.0 kg, P < 0.05) and BMI (0.5 ± 1.1 kg/m2, P < 0.05) increased in the CG, with no change in the TG.ConclusionAIT, combined with adherence support, of out‐patients with schizophrenia was feasible, improved , and may be integrated in standard care. (ClinicalTrials.gov identifier: NCT02743143).
Power, Subsidiarity, and the Economy of Exclusion
Authors: Clark Charles M. A. 
Published: October 2019

AbstractAccording to Pope Francis, an “economy of exclusion” is an economy with barriers that prevent individuals and groups from participating in the economy and society to their full potential. Power is a key determinant for both exclusion and inclusion. All economies are based on power relations and an “economy of exclusion” is an abuse of power. This contribution looks at what economic power is and how it can build barriers of exclusion or pathways to inclusion. We use income inequality as a measure of exclusion, giving a general history of power and inequality to demonstrate the role of power. Lastly, we look at the concept of subsidiarity in Catholic social thought as a principle to guide the use of power in the economy.
Pimozide suppresses cancer cell migration and tumor metastasis through binding to ARPC2, a subunit of the Arp2/3 complex
Authors: Choi Jiyeon , Lee Yu‐Jin , Yoon Yae Jin , Kim Cheol‐Hee , Park Seung‐Jin , Kim Seon‐Young , Doo Kim Nam , Cho Han Dong , Kwon Byoung‐Mog 
Published: October 2019

AbstractARPC2 is a subunit of the Arp2/3 complex, which is essential for lamellipodia, invadopodia and filopodia, and ARPC2 has been identified as a migrastatic target molecule. To identify ARPC2 inhibitors, we generated an ARPC2 knockout DLD‐1 human colon cancer cell line using the clustered regularly interspaced short palindromic repeats/CRISPR‐associated protein 9 (CRISPR/Cas9) system and explored gene signature‐based strategies, such as a connectivity map (CMap) using the gene expression profiling data of ARPC2 knockout and knockdown cells. From the CMap‐based drug discovery strategy, we identified pimozide (a clinically used antipsychotic drug) as a migrastatic drug and ARPC2 inhibitor. Pimozide inhibited the migration and invasion of various cancer cells. Through drug affinity responsive target stability (DARTS) analysis and cellular thermal shift assay (CETSA), it was confirmed that pimozide directly binds to ARPC2. Pimozide increased the lag phase of Arp2/3 complex‐dependent actin polymerization and inhibited the vinculin‐mediated recruitment of ARPC2 to focal adhesions in cancer cells. To validate the likely binding of pimozide to ARPC2, mutant cells, including ARPC2F225A, ARPC2F247A and ARPC2Y250F cells, were prepared using ARPC2 knockout cells prepared by gene‐editing technology. Pimozide strongly inhibited the migration of mutant cells because the mutated ARPC2 likely has a larger binding pocket than the wild‐type ARPC2. Therefore, pimozide is a potential ARPC2 inhibitor, and ARPC2 is a new molecular target. Taken together, the results of the present study provide new insights into the molecular mechanism and target that are responsible for the antitumor and antimetastatic activity of pimozide.
Framework for monitoring shrubland community integrity in California Mediterranean type ecosystems: Information for policy makers and land managers
Authors: Lawson Dawn M. , Keeley Jon E. 
Published: October 2019

AbstractShrublands in Mediterranean‐type ecosystems worldwide support important ecosystem services including high levels of biodiversity and are threatened by multiple factors in heavily used landscapes. Use, conservation, and management of these landscapes involve diverse stakeholders, making decision processes complex. To be effective, management and land use decisions should be informed by current information on ecosystem quality and resilience. However, obtaining this information is often a challenge due to the extent of landscapes involved. Here we present a conceptual integrity monitoring framework based on simple easily observable ecosystem components readily understood by nonspecialists. Community integrity is defined by plant functional group based on relative proportion of shrubs and nonnative annual grasses. The ability to use these straightforward metrics results from four factors: relatively good alignment of characteristic bird, mammal, and insect communities with shrub cover, positive feedback between annual grasses and short fire intervals, the inhibitory effect of annual grasses on shrub seedling establishment, and similar functional group response to different disturbances. Two additional metrics, indicator species and shrub species diversity, capture subtle yet persistent signatures of disturbance on integrity not reflected in functional group composition. The framework is designed to: categorize habitats into ecosystem integrity classes, forecast likely integrity class changes caused by threats and environmental conditions, and provide a simple reporting mechanism that can be overlain with data on conservation status and vulnerabilities. The proposed framework includes a pilot phase to validate empirical relationships, thresholds, and sampling efficiency. The accessibility of these metrics to nonspecialists is anticipated to enhance communication among stakeholders and thus facilitate problem solving. Leveraging monitoring and mapping programs driven by other needs (e.g., species conservation and fire management) affords meaningful opportunities to offset program costs.
Scenographic Exhibitions as Spaces of Encounter
Authors: Mehzoud Sven 
Published: October 2019

AbstractThis research article discusses theatre and performance‐based exhibition design strategies and their application for the display and engagement with narratives about landscape, place and country. The Interpretive Wonderings* mapping project and exhibition serves as a case study to discuss the application of an expanded scenographic exhibition practice. Interpretive Wonderings was shaped by the coming together of community and artists in regional New South Wales, Australia, and was the result of a partnership between Culpra Milli Aboriginal Corporation, an Aboriginal organization that holds and manages land on behalf of its members, researchers from three Australian universities and a regional Arts Centre. Through this project, curatorial and design processes are reconsidered using a performance‐based lens to address engagement with complex and politically contentious narratives.*Editorial note: The Interpretive Wonderings Portfolio comprises a set of interrelated writings that attempt to provide a distinctive, multi‐perspectival account of this creative research project. In addition to this research piece, other articles include: a co‐authored contextual overview which situates the project in theoretical and practical terms’, a compilation of short texts that offer reflective analyses from the different perspectives of the project’s curatorium and principal researchers, Sophia Pearce, Campbell Drake, Jock Gilbert and Sven Mehzoud, and an associated research‐led article by Gilbert (2019, this issue). Read individually, each designated article presents a focused inquiry (depth); taken together as a curated series, they provide the reader with the opportunity to gain a comprehensive overview (breadth) and appreciation of the project’s guiding aspirations, objectives and outcomes that amounts to more than the sum of its discrete parts.