bluuebunny/crossref_metadata_2025_split huggingface dataset:
Load Shedding Analysis Because of Contingency Damage (N-2) at Transmission Lines 150 kV Subsystem Cirata
Authors: Sucita T , Mulyadi Y , Saputra W S 
Published: July 2018

Abstract
Cirata subsystem is part of the 150 kV interconnection system 150 kV West Java which is supplied by two units of IBT 500/150 kV with a power capacity of each IBT is 500 MVA. It has 15 transmission line connecting the substation 13 (GI), while the generation units that exist in the subsystem Cirata is PLTP Patuha with a power of 55 MW and 180 MW hydropower Jatiluhur. The reliability of the power system must be maintained in order to supply power from the generator to the consumer to keep going well. At peak load conditions and contingencies, an electric power system will undergo changes in value, both current and voltage. In this study, which analyzed disorder is a contingency (N-2), a discharge of the two components of transmission line system and generator. The aim is to evaluate and improve the reliability of electric power systems of 150 kV Subsystem Cirata, analyzing the effects of disturbance contingency (N-2) to changes in current and voltage, identify the bus voltage is outside the operating limits, identifying the transmission line that experienced the imposition of critical / exceeds limit operation, and perform load shedding (load sheeding) to overcome the weaknesses of the power system due to disruption contingency N-2. The study was conducted by collecting data required for power flow simulation using Newton-Raphson method in ETAP 12.6.0. The simulation results show the power flow interruption due to voltage profile under the standard contingency SPLN 150 kV + 5% and -10%, and becomes critical channel loading over 50% of the nominal current conductor. While after the release of the load (load sheeding) voltage profile in Subsystem Cirata back normal or standardized SPLN and loading the channel becomes lighter.
Very Sort Term Load Forecasting Using Interval Type - 2 Fuzzy Inference System (IT- 2 FIS) (Case Study: Java Bali Electrical System)
Authors: Jamaaluddin J , Hadidjaja D , Sulistiyowati I , Suprayitno E A , Anshory I , Syahrorini S , Abdullah A G 
Published: July 2018

Abstract
One of the important things to do an electric power system operation is load forecasting. Load forecasting consists of short-term forecasting and short-term forecasting. The very short term load forecasting are required for regulating electrical energy generation, maintenance arrangements and regulating the labor involved. This forecasting is done to decide which plant to operate. The capacity of the plant to be operated adjusts to the load plan to be supplied the next day. The very short-term load forecasting is predicting electrical loads with time intervals every 30 minutes for the next day. In this study using Interval Type-2 Fuzzy Inference System (IT-2FIS) because it delivers a high flexibility that can be developed using other methods (hybrid). Laying out the footprint of uncertainty (FOU) membership function of the Interval Type-2 Fuzzy Inference System (IT-2FIS). This method has been applied for short- term load forecasting and will be employed for very short-term forecasting. In very short-term load forecasting IT-2 FIS has Mean Average Percentage Error (MAPE) arround 0,729%.
No Evidence of “healthy neuroticism” in the Hawaii Personality and Health Cohort
Authors: Weston Sara J , Hill Patrick L , Edmonds Grant W , Mroczek Daniel K , Hampson Sarah E 
Published: July 2018

AbstractBackgroundHeterogeneity in the effects of trait neuroticism on mortality has inspired recent theories of “healthy neuroticism,” or the possibility that neuroticism can lead people down either healthy or unhealthy behavioral pathways. The logical extension of this theory is that some construct—perhaps another trait, financial resource, or health-relevant situation—changes the relationship between neuroticism and health. The other possibility is that different components of neuroticism lead to different health behaviors and therefore different outcomes.PurposeThe current study systematically examines the relationship between child and adult neuroticism and various health indicators including perceptions of health, behaviors, health outcomes, and biomarkers of health. Finally, we examine both potential moderators of the associations with neuroticism and examine its facet structure.MethodsThe current study utilizes data from the Hawaii Longitudinal Study of Personality and Health, which includes both adult (IPIP-NEO) and childhood (teacher-reported) measures of personality and socioeconomic status, as well as a variety of health outcomes, from self-reported health and health behavior to biological markers, such as cholesterol and blood glucose levels. Sample sizes range from 299 to 518.ResultsThe relationship between neuroticism and health was not consistently moderated by any other variable, nor were facets of neuroticism differentially related to health.ConclusionsDespite a systematic investigation of the potential “paths” which may differentiate the relationship of neuroticism to health, no evidence of healthy neuroticism was found.
Lack of p11 expression facilitates acidity‐sensing function of TASK1 channels in mouse adrenal medullary cells
Authors: Inoue Masumi , Matsuoka Hidetada , Lesage Florian , Harada Keita 
Published: July 2018

ABSTRACTExternal acidity induces catecholamine secretion by inhibiting TASK1‐like channels in rat adrenal medullary (AM) cells. TASK channels can function as a heteromer or homomer in the TASK subfamily. In this study, we elucidate the molecular identity of TASK1‐like channels in mouse AM cells using gene knockout. Genetic deletion of TASK1, but not TASK3, abolished the depolarizing inward current and catecholamine secretion in response to acidity, whereas it did not affect the resting current level. Immunocytochemistry revealed that AM cells exhibited predominantly TASK1‐like and little TASK3‐like immunoreactivity. A proximity ligation assay showed that TASK1/3 heteromeric channels were not formed in AM cells or PC12 cells. However, the exogenous expression of p11 in PC12 cells resulted in the heteromeric formation of TASK isoforms, which were mainly located in the cytoplasm, and p11 was not expressed in rat adrenal medullae or PC12 cells. In AM cells, genetic deletion of TASK1 resulted in enhancement of the immunoreactivity of the TALK2 channel, but not TASK3. The results indicate that TASK1 homomeric channels function as acidity sensors in AM cells, and that function is facilitated by the lack of p11 expression.—Inoue, M., Matsuoka, H., Lesage, F., Harada, K. Lack of p11 expression facilitates acidity‐sensing function of TASK1 channels in mouse adrenal medullary cells. FASEB J. 33, 455–468 (2019). www.fasebj.org
Percutaneous needle quadriceps tenotomy for treatment of idiopathic congenital dislocation of the knee
Authors: Khaled Mohamed , Elgafary Kamal , El-adly Wael 
Published: July 2018

Background:
Congenital dislocation of the knee is a rare condition with an incidence of 1:100000 and can be idiopathic or syndromic. Our study evaluated percutaneous needle tenotomy for treatment of idiopathic flexible congenital dislocation of the knee.

Methods:
A prospective case series was done on 15 infants with idiopathic congenital dislocation of the knee: nine boys and six girls. Closed reduction was first attempted, and if it failed the knee was examined. If the knee could be flexed beyond 0, serial casting was done. If the knee could not be flexed beyond 0, percutaneous needle tenotomy was done.

Results:
Fifteen infants presented with idiopathic flexible congenital dislocation of the knee. Three dislocations were reduced closed, five were reduced with serial casting with gradual flexion, and seven that could not be flexed beyond 0 underwent percutaneous needle tenotomy. All patients could walk within the normal age range with no pain. All had full range of motion and good quadriceps function. Ultrasound was done in patients who had percutaneous needle tenotomy at walking age to ensure healing of the quadriceps tendon, which was adequately healed in all patients.

Conclusions:
Percutaneous needle tenotomy is a good option for treatment of congenital dislocation of the knee. Careful selection of patients is mandatory.
Preoperative IMRT for soft-tissue sarcoma of the extremities and trunk: low rate of wound complications
Authors: Studer Gabriela , Glanzmann Christoph , Maduz Franziska , Bode Beata , Fuchs Bruno 
Published: July 2018

Background:
The Canadian prospective randomized NCIC SR2 trial tested the sequence of radiation and surgery for extremity soft-tissue sarcoma. The trial was conducted in the era before intensity-modulated radiation therapy (IMRT) was clinically available. Similar disease control after preoperative and postoperative non-IMRT was found. However, the preoperative non-IMRT arm showed significantly less (persisting) late-term effects but increased (transient) wound complication rates compared to the postoperative non-IMRT arm (35% vs. 17%, P = 0.01). Consequently based on these results, preoperative radiation therapy was considered the preferred approach. Currently IMRT, with its option for highly conformal dose distribution that translates into better normal tissue sparing, is used as the general standard for sarcoma radiation therapy in most patients. Our hypothesis was that a lower wound complication rate after preoperative radiation therapy might be achievable in the IMRT era.

Methods:
We prospectively assessed our preoperative IMRT cohort (n=67 consecutive patients) treated between March 2008 and March 2016 with respect to wound complication rates.

Results:
Fourteen of 67 (21%) externally referred patients with recurrent (n=1) or incompletely resected disease (n=13), and 53 treatment-naive patients underwent planned preoperative radiation after core biopsy. After mean/median 7.3/7 wk (3-12 wk), complete tumor resection was performed. Secondary revision was required in five of 67 (i.e., wound complication rate of 7%). Two local failures were observed so far.

Conclusions:
The presented results support our hypothesis that preoperative IMRT may lead to a reduced wound complication rate compared to that after postoperative and mainly preoperative non-IMRT techniques.
Review of the Evaluation and Treatment of Vasovagal Reactions in Outpatient Procedures
Authors: Wu Wesley J. , Goldberg Leonard H. , Rubenzik Marc K. , Zelickson Blake R. 
Published: July 2018

BACKGROUND
A vasovagal reaction is a commonly encountered event in outpatient procedures. There is a paucity of discussion on vasovagal reactions (VVRs) in the dermatologic surgery literature. However, recent investigations in the physiology, evaluation, and treatment of VVRs have been reported in other specialties.

OBJECTIVE
A comprehensive review of the physiology, evaluation, treatment, and prevention of VVRs.

MATERIALS AND METHODS
A search as performed using the PubMed/MEDLINE databases. Search terms included “vasovagal,” “vasovagal reaction,” “syncope,” “reflex syncope,” “neurocardiogenic syncope,” and “fainting.”

RESULTS
Studies demonstrate greater understanding in the physiology of a vasovagal reaction. Although permanent sequelae are uncommon, it is important to respond in a prompt manner. A variety of treatment and prevention options are presented.

CONCLUSION
Vasovagal reactions should be carefully evaluated. Additional studies may provide greater data in understanding and managing vasovagal reactions.
Hyaluronic Acid After Subcutaneous Injection—An Objective Assessment
Authors: Santer Verena , Molliard Samuel Gavard , Micheels Patrick , Río-Sancho Sergio del , Quinodoz Pierre , Kalia Yogeshvar N. , Salomon Denis 
Published: July 2018

BACKGROUND
Hyaluronic acid (HA) fillers are the preferred injectable products for aesthetic correction of skin depressions and restoration of facial volume.

OBJECTIVE
To investigate the subcutaneous distribution of 3, biophysically distinct, CE-marked and FDA-approved HA fillers.

MATERIALS AND METHODS
BELB, JUVV, and RESL were injected ex vivo in porcine and human skin. Immediately after injection, the skin samples were snap-frozen, cross-sectioned, and visualized using stereomicroscopy and full-field optical coherence tomography. Images were compared with histological sections after hematoxylin and eosin staining.

RESULTS
Hyaluronic acid fillers were distributed as homogeneous bolus in the ex vivo skin. The injection bulks were found to preserve the fibrous trabecular network, shift the fat lobules, and displace the adjacent adipocyte layers independently of the formulation injected.

CONCLUSION
For the first time, the subcutaneous injection of 3 HA fillers with markedly different biophysical properties was systematically investigated by complementary visualization techniques. Despite their different properties, no difference in distribution was found after subcutaneous injection. The global preservation of the hypodermis structure observed was consistent with the good tolerability seen in clinical practice after implantation of the HA fillers in the subcutaneous skin layer.
Primary Modified Predescemetic Deep Anterior Lamellar Keratoplasty in Acute Corneal Hydrops
Authors: Jacob Soosan , Narasimhan Smita , Agarwal Amar , Sambath Jambulingam , Umamaheshwari Govindharaj , Saijimol Areeckal Incy 
Published: July 2018

Purpose:
To report primary treatment of acute corneal hydrops (CH) with a modified technique of predescemetic deep anterior lamellar keratoplasty (pdDALK).

Methods:
This prospective interventional case series included 9 eyes with acute CH that underwent pdDALK as primary treatment. Technique modifications included a bevel-up needle, creating tissue emphysema as a guide for dissection, using small aliquots of air directed away from break, manual deeper dissection using a blunt dissector, centripetal dissection leaving the area of Descemet membrane (DM) break for last, retention of minimal stroma above DM tear, and tamponade of DM tear with air in the anterior chamber. In eyes with extensive area of edema or thin residual stroma, an inked trephine mark was manually deepened with a sharp crescent blade, followed by other modifications.

Results:
All patients underwent uneventful surgery without enlargement of DM tear. The average follow-up period was 18 ± 13 months. All showed a clear, nonedematous graft with an area of DM defect seen and overlying cornea continuing to remain clear at final postoperative follow-up. ASOCT showed 90.8 ± 32 μm residual predescemetic host stroma on either side of the defect. CDVA improved from 0.002 ± 0.005 preoperatively to 0.35 ± 0.1 by an average of 2.3 ± 0.8 weeks and to 0.52 ± 0.13 at final postoperative follow-up.

Conclusions:
Primary pdDALK was possible as single-stage definitive treatment with early visual rehabilitation and avoidance of scarring in our case series. Simultaneous correction of pathology by closure of DM break, anatomical correction of ectasia and thinning, optical correction by improved corneal topography and by regaining corneal structure and transparency, and retention of host DM and endothelium are advantages. Advanced DALK surgeons may use this technique.
Butyrate, a Gut Bacterial Metabolite, Lowers Intraocular Pressure in Normotensive But Not in Hypertensive Rats
Authors: Skrzypecki Janusz , Żera Tymoteusz , Ufnal Marcin 
Published: July 2018

Background:
Accumulating evidence supports a role of gut bacterial metabolites in arterial blood pressure (BP) regulation. Since the mechanisms controlling intraocular pressure (IOP) and BP overlap, we hypothesized that butyrate, a bacterial metabolite, might affect both IOP and BP.

Methods:
IOP, BP, and heart rate (HR) were measured at baseline and after the intraperitoneal administration of either butyrate or a vehicle (0.9% NaCl) in anaesthetized normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR).

Results:
At baseline, there was no significant difference between WKY and SHR in IOP and HR, whereas BP was significantly higher in SHR. In WKY administration of butyrate produced a significant decrease in IOP and BP, which lasted throughout the experiment. IOP response to butyrate was similar between sham WKY and WKY, which had undergone unilateral superior cervical ganglion excision. In contrast, in SHR butyrate treatment did not affect IOP and produced only a transient decrease in BP. WKY showed no significant changes in HR whereas SHR exhibited an increase in HR.

Conclusions:
Butyrate, a gut bacterial metabolite, lowers IOP in normotensive but not in hypertensive rats. The effect is independent of ocular sympathetic innervation. Given that changes in BP followed a different pattern than changes in IOP it seems that butyrate lowers IOP independently of BP changes.
Prioritization of Reimplantation in Previously Successful Cochlear Implantation Following Natural Device Failure
Authors: Hochman Jordan B. , Pisa Justyn , Cham Bonnie 
Published: July 2018

Introduction:
Cochlear reimplantation procedures account for approximately 5% of all implant cases and may be caused by internal device failure, skin flap complications, or an unexpected decline in auditory performance. This issue, in concert with changing demographics, expanded audiometric candidacy criteria, adult bilateral implantation, and implantation for unilateral hearing loss, all place escalating pressure on device availability and resource allocation in a publically funded health care system.

Objective:
The predictable and problematic access to a scare medical resource requires rigor in establishing program priority and formal policy. We present a single cochlear implant center's working reflections and an attempt at a principled approach to rationing health care decisions.

Methods:
Different approaches to health care rationing are examined and discussed. We describe a method of allocation that is currently employed by a large Canadian quaternary care center and ground this method in important principles of distributive justice as they apply to health care systems.

Results:
We elect to recognize device failure as analogous to sudden sensorineural hearing loss, with the associated need to expedite reimplantation. We consider this an ethical approach grounded in the egalitarian principle of equality of opportunity within cohorts of patients.

Conclusion:
Porting the practice from sudden sensorineural hearing loss, the time-sensitive need for hearing restoration, and maximized communication outcomes, dictates prioritization for this patient population. The predicted evolution of health systems globally and the shape of future medical practice will be heavily influenced by both the macro and micro level resource-dependent decisions implant centers currently face.
Patients With Normal Hearing Thresholds but Difficulty Hearing in Noisy Environments: A Study on the Willingness to Try Auditory Training
Authors: Spehar Brent P. , Lichtenhan Jeffery T. 
Published: July 2018

Hypothesis:
Persons with normal audiometric thresholds but excessive difficulty hearing in background noise will choose auditory training as a treatment option.

Background:
Auditory training has traditionally been reserved for those with marked hearing loss. We investigated auditory training as a treatment option for those who have normal auditory thresholds but complain about hearing in noise—a population of patients for which no therapy or intervention currently exists. We also determined the willingness of this patient population to volunteer for a free auditory training program.

Methods:
We administered a 14-item, telephone-based questionnaire to assess perceived difficulty hearing in noise and willingness to volunteer for auditory training. We developed questions to identify those who consistently reported difficulty hearing in noise, but not quiet.

Results:
The 11,938-person database included 2,299 patients with pure-tone averages less than 25. A total of 474 of these patients completed our questionnaire, 135 of who had normal audiometric thresholds at all octave frequencies 0.25 to 8 kHz. We found that difficulty hearing in noise was a graded problem. Our approach to find consistent reports about hearing in noise showed that the majority of people who consistently had difficulty hearing in noise, but not quiet, were the most likely to try auditory training.

Conclusions:
While relatively few patients with both normal hearing thresholds and complaints of severe difficulty hearing in noise were in the database, these patients were generally willing to volunteer for auditory training. Our results provide evidence that many in this underserved population would volunteer for auditory training.
Tolerance induction in hemophilia: innovation and accomplishments
Authors: Sherman Alexandra , Biswas Moanaro , Herzog Roland W. 
Published: July 2018

Purpose of review
Hemophilia is an X-linked blood coagulation genetic disorder, which can cause significant disability. Replacement therapy for coagulation factor VIII (hemophilia A) or factor IX (hemophilia B) may result in the development of high-affinity alloantibodies (’inhibitors’) to the replacement therapy, thus making it ineffective. Therefore, there is interest in directing immunological responses towards tolerance to infused factors.

Recent findings
In this review, we will discuss latest advancements in the development of potentially less immunogenic replacement clotting factors, optimization of current tolerance induction protocols (ITI), preclinical and clinical data of pharmacological immune modulation, hepatic gene therapy, and the rapidly advancing field of cell therapies. We will also evaluate publications reporting data from preclinical studies on oral tolerance induction using chloroplast-transgenic (transplastomic) plants.

Summary
Until now, no clinical prophylactic immune modulatory protocol exists to prevent inhibitor formation to infused clotting factors. Recent innovative technologies provide hope for improved eradication and perhaps even prevention of inhibitors.
Factor XII in inflammation and wound healing
Authors: Stavrou Evi X. 
Published: July 2018

Purpose of review
This review describes the contribution of coagulation factor XII (FXII) in sterile inflammation and wound healing, focusing on recently identified roles for zymogen FXII in neutrophil functions.

Recent findings
Recent studies have identified an important role for FXII in neutrophil trafficking. In particular, following neutrophil activation, autocrine FXII signals through the urokinase plasminogen activator receptor (uPAR) on the neutrophil surface to upregulate neutrophil functions. The sum of these activities leads to neutrophil adhesion, chemotaxis, and neutrophil extracellular (NET) formation. Downregulating FXII-mediated signaling in neutrophils is associated with improved wound healing.

Summary
These recent findings show the sophisticated role of FXII in vivo and create new opportunities for research on the treatment of chronic inflammatory diseases.
Influencing the Binge-Drinking Culture on a College Campus
Authors: Kessler Theresa A. , Kurtz Christine P. 
Published: July 2018

Background
The college years are a time of transition in which students experiment with behaviors including use of alcohol. Nursing students can be instrumental in supporting positive health behaviors and influencing the drinking culture.

Purpose
This article describes the findings of a collaborative nursing student-faculty research project about alcohol use with a focus on binge drinking.

Methods
Using a nursing student-faculty collaborative model, a longitudinal design was used to evaluate a mass media campaign with social norming messages and education to influence the drinking culture on a college campus.

Results
Students in Greek life and athletics engaged in binge drinking significantly more than other students. Students observed the mass media messages, with 81.9% viewing posters. A significant decrease in binge drinking was reported.

Conclusions
The nursing student-faculty team implemented a mass media campaign, which was effective at influencing the drinking culture on a college campus.