bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of acupressure on labor pain and the duration of labor when applied to the SP6 point: Randomized clinical trial
Authors: Türkmen Hülya , Çeber Turfan Esin 
Published: October 2019

AbstractAimThis study aims to determine the effect of acupressure (SP6) on first stage of labor pain and duration.MethodsA single blind, randomized controlled experimental trial was conducted with 60 pregnant women: 30 in the experimental group and 30 in the control group. At the active and transition stages of labor, acupressure was applied to the SP6 point of the experimental group, and the SP6 point of the control group was touched each contraction. The data were collected using the Pregnant Information Form. The Partograph Form was used to determine the duration of active stage and transition stage. The labor pain severity was measured using a numeric rating scale (NRS) immediately after each acupressure/touch SP6 in active and transition stages. A participant questionnaire on satisfaction was administered in the immediate postnatal period. The group difference was tested for statistical significance using the Chi‐square test, Fisher's exact test, and the Mann–Whitney U test.ResultsAs the primary outcome, labor pain was less and duration of labor was shorter for the experimental group. As the secondary outcome, satisfaction was increased that could be as a result of reduced pain in labor and/or shorter duration of labor. The perceived pain level in the active stage in the experimental group (n = 30) was less than the control group (n = 30) (labor pain: 7.17 + 0.89 vs. 7.66 + 0.71, p = .002). The mean duration of the first stage of labor in the experimental group was shorter than the control group (4.88 + 0.85 hr vs. 5.56 ± 0.66, p = .001). It was also found that pregnant women in the experimental group would recommend this method to other pregnant women (Chi‐square = 5.711, p = .017).ConclusionsApplication of acupressure on SP6 was found to have a positive effect on pregnant women's labor experience and reducing the labor pain and shortening the duration of first stage of labor compared to touch on SP6. The women receiving acupressure had higher levels of satisfaction in acupressure application than women receiving only touch on SP6, which could be as a result of reduced pain in labor and/or shorter duration of labor.
The interactions of dopamine and oxidative damage in the striatum of patients with neurodegenerative diseases
Authors: Li Huifangjie , Yang Pengfei , Knight William , Guo Yingqiu , Perlmutter Joel S. , Benzinger Tammie L. S. , Morris John C. , Xu Jinbin 
Published: October 2019

AbstractThe striatum with a number of dopamine containing neurons, receiving projections from the substantia nigra and ventral tegmental area; plays a critical role in neurodegenerative diseases of motor and memory function. Additionally, oxidative damage to nucleic acid may be vital in the development of age‐associated neurodegeneration. The metabolism of dopamine is recognized as one of the sources of reactive oxygen species through the Fenton mechanism. The proposed interactions of oxidative insults and dopamine in the striatum during the progression of diseases are the hypotheses of most interest to our study. This study investigated the possibility of significant interactions between these molecules that are involved in the late‐stage of Alzheimer's disease (AD), Parkinson disease (PD), Parkinson disease dementia, dementia with Lewy bodies, and controls using ELISA assays, autoradiography, and mRNA in situ hybridization assay. Interestingly, lower DNA/RNA oxidative adducts levels in the caudate and putamen of diseased brains were observed with the exception of an increased DNA oxidative product in the caudate of AD brains. Similar changes were found for dopamine concentration and vesicular monoamine transporter 2 densities. We also found that downstream pre‐synaptic dopamine D1 Receptor binding correlated with dopamine loss in Lewy body disease groups, and RNA damage and β‐site APP cleaving enzyme 1 in the caudate of AD. This is the first demonstration of region‐specific alterations of DNA/RNA oxidative damage which cannot be viewed in isolation, but rather in connection with the interrelationship between different neuronal events; chiefly DNA oxidative adducts and density of vesicular monoamine transporter 2 densities in AD and PD patients.
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Collaborative Care to Improve Access and Quality in School‐Based Behavioral Health
Authors: Lyon Aaron R. , Whitaker Kelly , Richardson Laura P. , French William P. , McCauley Elizabeth 
Published: October 2019

ABSTRACTBACKGROUNDCollaborative care (CC) is a well‐established approach for the delivery of accessible behavioral health services in integrated health care settings. Substantial evidence supports its effectiveness in improving the quality and outcomes of adult services, and growing research indicates utility with child and adolescent populations.METHODSTo date, studies examining CC models for youth have focused exclusively on primary‐care settings. Nevertheless, as the most common integrated service delivery setting for youth, the education sector is an equally important context for improving access to behavioral health services for children and adolescents.RESULTSWe provide a narrative review of the literature on CC, describes the relevance of CC to schools, and details its alignment with contemporary movements in education and school‐based behavioral health.CONCLUSIONSPotential adaptations of the CC model for use in schools are detailed to improve: (1) behavioral health service accessibility, (2) the capacity of schools to provide behavioral health services, and (3) school service effectiveness through use of evidence‐based practices. Although little research has explored the applicability of CC in the education sector, the model holds potential promise to improve the quality and efficiency of school‐based behavioral health services.
Peppermint and caraway oils have muscle inhibitory and pro‐secretory activity in the human intestine in vitro
Authors: Krueger Dagmar , Schäuffele Stefanie , Zeller Florian , Demir Ihsan Ekin , Theisen Jörg , Michel Klaus , Schemann Michael 
Published: October 2019

AbstractBackgroundHerbal medicinal products with a broad activity spectrum may be promising alternatives to treat functional gastrointestinal disorders (FGD). Menthacarin® is a drug with a fixed combination of peppermint and caraway oils, which is clinically used to treat FGD‐associated symptoms.MaterialsWe studied the effects of peppermint and caraway oils on contractile and secretory activity in 255 human small and large intestinal preparations derived from surgical resections (73 patients). Motility was recorded in circular smooth muscle strips and secretion with the Ussing chamber‐voltage clamp technique. Electrical field stimulation evoked nerve induced contractile responses.Key ResultsPeppermint and caraway oil concentrations dependently inhibited muscle contractility as indicated by sustained muscle relaxation and decrease in phasic contractility. These effects occurred in small and large intestinal preparations with IC50 values ranging between 17 and 90 µg/mL for peppermint oil and between 7 and 127 µg/mL for caraway oil. Neither peppermint nor caraway oil influenced the nerve evoked contractile response. The inhibition of contractile activity, but not the muscle relaxation, was prevented by the L‐type calcium channel activator Bay K8644 but not by the neurotoxin tetrodotoxin. Both peppermint oil and caraway oil increased epithelial secretion, which remained in tetrodotoxin.Conclusion & InterferenceThe findings revealed a strong muscle inhibitory and pro‐secretory action of peppermint and caraway oils at clinically relevant concentrations. Both actions were nerve‐independent. The inhibition of contractility was mediated by inhibition of L‐type calcium channels. The effects on muscle and epithelial activity may contribute to the beneficial effects observed in patients with FGD.
Pilot testing the effectiveness of the Healthy Ageing Supported by Internet and Community programme for promoting healthy lifestyles for people over 65 years of age
Authors: García‐Camacha Aurora , García‐Camacha Irene , Martínez‐Andrés María , Notario‐Pacheco Blanca , Rodríguez‐Martín Beatriz 
Published: October 2019

Active ageing is associated with physical, social and mental wellbeing, as well as the participation and integration of older people in society. Currently, demographic changes represent a major challenge while reinforcing the need to improve our current understanding of active ageing and promote appropriate interventions suitable for older people. The aim of this pilot study was to evaluate the impact of the Healthy Ageing Supported by Internet and Community training programme for acquiring the knowledge and skills necessary for adopting a healthy lifestyle in community‐dwelling adults over 65 years of age. This study was conducted between 2015 and 2016 and was based on a convenience sample of individuals who responded to questionnaires. The study participants comprised all those who were included in the training programme (n = 71, 47 mentors and 24 participants in peer groups). The statistical analysis demonstrated the effectiveness of the programme regarding feasibility and expected results (p < 0.05 for most items, individually, as well as for the total scores of each test dimension). The programme was based on peer group training and the use of information and communication technologies and proved to be effective for acquiring the knowledge and skills necessary for adopting a healthy lifestyle. Furthermore, increased health scores were obtained in the physical, mental and social domains. It could also be beneficial for other groups of older people in order to support their integration into society, enhance their social skills and decrease any feelings of loneliness and rejection.
Case matching and syncretism in ATB‐dependencies
Authors: Hein Johannes , Murphy Andrew 
Published: October 2019

AbstractSyncretism has been reported to have the peculiar property of repairing violations of syntactic constraints, e.g. with agreement (Schütze 2003, Bhatt & Walkow 2013) and case matching (Citko 2005, van Craenenbroeck 2012). This paper puts forward the view that in one well‐reported instance of syncretism repair of case‐matching violations with ATB‐movement, this repair follows directly from the nature of ATB movement. We pursue a novel movement‐based analysis in which ATB movement involves the actual fusion of two syntactic objects, via intersection of feature sets. As well as deriving the one‐to‐many relation between fillers and gaps in ATB, we show how the ‘repair’ effect of syncretism with case matching violations follows naturally under this approach.
Changing perspectives on how the permeation pathway through potassium channels is regulated
Authors: Black Katrina A. , Jin Ruitao , He Sitong , Gulbis Jacqueline M. 
Published: October 2019

AbstractThe primary means by which ion permeation through potassium channels is controlled, and the key to selective intervention in a range of pathophysiological conditions, is the process by which channels switch between non‐conducting and conducting states. Conventionally, this has been explained by a steric mechanism in which the pore alternates between two conformations: a ‘closed’ state in which the conduction pathway is occluded and an ‘open’ state in which the pathway is sufficiently wide to accommodate fully hydrated ions. Recently, however, ‘non‐canonical’ mechanisms have been proposed for some classes of K+ channels. The purpose of this review is to illuminate structural and dynamic relationships underpinning permeation control in K+ channels, indicating where additional data might resolve some of the remaining issues.
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A Vine Copula-Based Hierarchical Framework for Multiscale Uncertainty Analysis
Authors: Xu Can , Liu Zhao , Tao Wei , Zhu Ping 
Published: October 2019

Abstract
Uncertainty analysis is an effective methodology to acquire the variability of composite material properties. However, it is hard to apply hierarchical multiscale uncertainty analysis to the complex composite materials due to both quantification and propagation difficulties. In this paper, a novel hierarchical framework combined R-vine copula with sparse polynomial chaos expansions is proposed to handle multiscale uncertainty analysis problems. According to the strength of correlations, two different strategies are proposed to complete the uncertainty quantification and propagation. If the variables are weakly correlated or mutually independent, Rosenblatt transformation is used directly to transform non-normal distributions into the standard normal distributions. If the variables are strongly correlated, the multidimensional joint distribution is obtained by constructing R-vine copula, and Rosenblatt transformation is adopted to generalize independent standard variables. Then, the sparse polynomial chaos expansion is used to acquire the uncertainties of outputs with relatively few samples. The statistical moments of those variables that act as the inputs of next upscaling model can be gained analytically and easily by the polynomials. The analysis process of the proposed hierarchical framework is verified by the application of a 3D woven composite material system. Results show that the multidimensional correlations are modeled accurately by the R-vine copula functions, and thus uncertainty propagations with the transformed variables can be done to obtain the computational results with consideration of uncertainties accurately and efficiently.
Computational Fluid Dynamics Investigations of Breaking Focused Wave-Induced Loads on a Monopile and the Effect of Breaker Location
Authors: Aggarwal Ankit , Tomaselli Pietro D. , Christensen Erik Damgaard , Bihs Hans 
Published: October 2019

Abstract
The design of new offshore structures requires the calculation of the wave-induced loads. In this regard, the computational fluid dynamics (CFD) methodology has shown to be a reliable tool, in the case of breaking waves especially. In this paper, two CFD models are tested in the reproduction of the experimental spilling waves impacting a circular cylinder for four different wave impact scenarios for focused waves. The numerical and experimental free surface elevations at different locations around the cylinder are also compared to verify the both numerical models. The numerical results from the models are shown together with the experimental measurements. Both CFD models are able to model the impact forces with a reasonable accuracy. When the cylinder is placed at a distance of 0.7 m from the wave breaking point, the value of the measured wave impact forces is highest due to the overturning wave crest and air entrainment. The wave-induced impact forces decrease, when the monopile is placed at distances further away from the breaking location.
A Novel Approach for Enhancing Thermal Performance of Battery Modules Based on Finite Element Modeling and Predictive Modeling Mechanism
Authors: Garg Akhil , Ruhatiya C. , Cui Xujian , Peng Xiongbin , Bhalerao Yogesh , Gao Liang 
Published: October 2019

Abstract
Electric vehicles (EVs) are estimated as the most sustainable solutions for future transportation requirements. However, there are various problems related to the battery pack module and one such problem is invariable high-temperature differences across the battery pack module due to the discharging and charging of batteries under operating conditions of EVs. High-temperature differences across the battery module contribute to the degradation of maximum charge storage and capacity of Li-ion batteries which ultimately affects the performance of EVs. To address this problem, a finite element modeling (FEM) based automated neural network search (ANS) approach is proposed. The research methodology constitutes of four stages: design of air-cooled battery pack module, setup of the FEM constraints and thermal equations, formulating the predictive model on generated data using ANS, and lastly performing multi-objective response optimization of the best fit predictive model to formulate optimum design constraints for the air-cooled battery module. For efficient thermal management of the battery module, an empirical model is formulated using the mentioned methodology for minimizing the maximum temperature differences, standard deviation of temperature across the battery pack module, and battery pack volume. The results obtained are as follows: (1) the battery pack module volume is reduced from 0.003279 m3 to 0.002321 m3 by 29.21%, (2) the maximum temperature differences across the eight cells of battery pack module declines from 6.81 K to 4.38 K by 35.66%, and (3) the standard deviation of temperature across battery pack decreases from 4.38 K to 0.93 K by 78.69%. Thus, the predictive empirical model enhances the thermal management and safety factor of battery module.
Prediction of Transient Statistical Energy Response for Two-Subsystem Models Considering Interval Uncertainty
Authors: Chen Qiang , Fei Qingguo , Wu Shaoqing , Li Yanbin 
Published: October 2019

Abstract
The transient response analysis is important for the design and evaluation of uncertain engineering systems under impact excitations. In this paper, statistical energy analysis (SEA) is developed to evaluate the high-frequency transient energy response of two-subsystem models considering interval uncertainties. Affine arithmetic (AA) and a subinterval technique are introduced into SEA to improve the computational accuracy. Numerical simulations on a coupled-plate and a plate-cavity system considering interval uncertainties are performed. The analysis precision of the proposed approach is validated by Monte Carlo (MC) method. The results show that the analysis precision of the proposed method decreases with the increasing uncertainty level of parameters. The computational accuracy of the proposed method can be significantly improved by employing AA and subinterval technique.
Measurement Characteristics of Athlete Monitoring Tools in Professional Australian Football
Authors: Ryan Samuel , Pacecca Emidio , Tebble Jye , Hocking Joel , Kempton Thomas , Coutts Aaron J. 
Published: October 2019

Purpose: To examine the measurement reliability and sensitivity of common athlete monitoring tools in professional Australian Football players. Methods: Test–retest reliability (noise) and weekly variation (signal) data were collected from 42 professional Australian footballers from 1 club during a competition season. Perceptual wellness was measured via questionnaires completed before main training sessions (48, 72, and 96 h postmatch), with players providing a rating (1–5 Likert scale) regarding their muscle soreness, sleep quality, fatigue level, stress, and motivation. Eccentric hamstring force and countermovement jumps were assessed via proprietary systems once per week. Heart rate recovery was assessed via a standard submaximal run test on a grass-covered field with players wearing a heart rate monitor. The heart rate recovery was calculated by subtracting average heart rate during final 10 seconds of rest from average heart rate during final 30 seconds of exercise. Typical test error was reported as coefficient of variation percentage (CV%) and intraclass coefficients. Sensitivity was calculated by dividing weekly CV% by test CV% to produce a signal to noise ratio. Results: All measures displayed acceptable sensitivity. Signal to noise ratio ranged from 1.3 to 11.1. Intraclass coefficients ranged from .30 to .97 for all measures. Conclusions: The heart rate recovery test, countermovement jump test, eccentric hamstring force test, and perceptual wellness all possess acceptable measurement sensitivity. Signal to noise ratio analysis is a novel method of assessing measurement characteristics of monitoring tools. These data can be used by coaches and scientists to identify meaningful changes in common measures of fitness and fatigue in professional Australian football.
The Effects of Cluster-Set and Traditional-Set Postactivation Potentiation Protocols on Vertical Jump Performance
Authors: Dello Iacono Antonio , Beato Marco , Halperin Israel 
Published: October 2019

Purpose: To compare the effects of 2 postactivation potentiation (PAP) protocols using traditional-set or cluster-set configurations on countermovement jump performance. Methods: Twenty-six male basketball players completed 3 testing sessions separated by 72 hours. On the first session, subjects performed barbell jump squats with progressively heavier loads to determine their individual optimum power load. On the second and third sessions, subjects completed 2 PAP protocols in a randomized order: 3 sets of 6 repetitions of jump squats using optimum power load performed with either a traditional-set (no interrepetition rest) or a cluster-set (20-s rest every 2 repetitions) configuration. After a warm-up, countermovement jump height was measured using a force platform before, 30 seconds, 4 minutes, and 8 minutes after completing the PAP protocols. The following kinetic variables were also analyzed and compared: relative impulse, ground reaction force, eccentric displacement, and vertical leg-spring stiffness. Results: Across both conditions, subjects jumped lower at post 30 seconds by 1.21 cm, and higher in post 4 minutes by 2.21 cm, and in post 8 minutes by 2.60 cm compared with baseline. However, subjects jumped higher in the cluster condition by 0.71 cm (95% confidence interval, 0.37 to 1.05 cm) in post 30 seconds, 1.33 cm (95% confidence interval, 1.02 to 1.65 cm) in post 4 minute, and 1.64 cm (95% confidence interval, 1.41 to 1.88 cm) in post 8 minutes. The superior countermovement jump performance was associated with enhanced kinetic data. Conclusions: Both protocols induced PAP responses in vertical jump performance using jump squats at optimum power load. However, the cluster-set configuration led to superior performance across all time points, likely due to reduced muscular fatigue.