bluuebunny/crossref_metadata_2025_split huggingface dataset:
Marketplace Shrimp Mislabeling in North Carolina
Authors: Korzik Morgan L. , Austin Hannah M. , Cooper Brittany , Jasperse Caroline , Tan Grace , Richards Emilie , Spencer Erin T. , Steinwand Blaire , Fodrie F. Joel , Bruno John F. 
Published: August 2019

AbstractSeafood mislabeling occurs in a wide range of seafood products worldwide, resulting in public distrust, economic fraud, and health risks for consumers. We quantified the extent of shrimp mislabeling in coastal and inland North Carolina. We used standard DNA barcoding procedures to determine the species identity of 106 shrimp sold by 60 vendors across North Carolina as “local” shrimp. Thirty-four percent of the purchased shrimp was mislabeled, and surprisingly the percentage did not differ significantly between coastal and inland counties. Roughly one third of product incorrectly marketed as “local” was in fact whiteleg shrimp: an imported, and very likely farmed, species from the eastern Pacific (and not found in North Carolina waters). In addition to the negative ecosystem consequences of shrimp farming (e.g., the loss of mangroves forests and the coastal buffering they provide) and seafood importation, North Carolina fishers—as with local fishers elsewhere—are negatively impacted when vendors label farmed, frozen, and imported shrimp as local, fresh, and wild-caught.
Over the rainbow: a practical guide for fluorescent protein selection in plant FRET experiments
Authors: Denay Grégoire , Schultz Patrick , Hänsch Sebastian , Weidtkamp-Peters Stefanie , Simon Rüdiger 
Published: August 2019

AbstractReceptor-like kinases (RLK) and receptor-like proteins (RLP) often interact in a combinatorial manner depending on tissue identity, membrane domains, or endo- and exogenous cues, and the same RLKs or RLPs can generate different signaling outputs depending on the composition of the receptor complexes they are involved in. Investigation of their interaction partners in a spatial and dynamic way is therefore of prime interest to understand their functions. This is however limited by the technical complexity of assessing it in endogenous conditions. A solution to close this gap is to determine protein interaction directly in the relevant tissues at endogenous expression levels using Förster resonance energy transfer (FRET). The ideal fluorophore pair for FRET must, however, fulfil specific requirements: (i) the emission and excitation spectra of the donor and acceptor, respectively, must overlap; (ii) they should not interfere with proper folding, activity, or localization of the fusion proteins; (iii) they should be sufficiently photostable in plant cells. Furthermore, the donor must yield sufficient photon counts at near-endogenous protein expression levels. Although many fluorescent proteins were reported to be suitable for FRET experiments, only a handful were already described for applications in plants. Herein, we compare a range of fluorophores, assess their usability to study RLK interactions by FRET-based fluorescence lifetime imaging (FLIM) and explore their differences in FRET efficiency. Our analysis will help to select the optimal fluorophore pair for diverse FRET applications.One-sentence summaryWe compared the performances of several different fluorescent protein pairs to study membrane protein interaction in plants with FRET.
Combined efficacy of a novel antimicrobial cationic peptide polymer with conventional antibiotics to combat multi-drug resistant pathogens
Authors: Thappeta Kishore Reddy , Vikhe Yogesh Shankar , Yong Adeline Mei Hui , Park Mary B. Chan , Kline Kimberly A. 
Published: August 2019

ABSTRACTAntibiotic-resistant infections are predicted to kill 10 million people worldwide per year by 2050 and to cost the global economy 100 trillion USD. Novel approaches and alternatives to conventional antibiotics are urgently required to combat antimicrobial resistance. We have synthesized a chitosan-based oligolysine antimicrobial peptide, CSM5-K5, which targets multidrug resistant (MDR) bacterial species. Here we show that CSM5-K5 exhibits rapid bactericidal activity against methicillin resistantStaphylococcus aureus(MRSA), MDREscherichia coli, and vancomycin resistantEnterococcus faecalis(VRE). Combinatorial therapy of CSM5-K5 with antibiotics to which each organism is otherwise resistant restores sensitivity to the conventional antibiotic. CSM5-K5 alone significantly reduced pre-formed bacterial biofilm by two-four orders of magnitude and, in combination with traditional antibiotics, reduced pre-formed biofilm by more than two-three orders of magnitude at sub inhibitory concentrations. Moreover, using a mouse excisional wound infection model, CSM5-K5 treatment reduced bacterial burdens by one to three orders of magnitude, and acted synergistically with vancomycin and tetracycline to clear VRE and MDRE. coli,respectively. Importantly, little to no resistance against CSM5-K5 arose for any of the three MDR bacteria during 15 days of serial passage. This work demonstrates the feasibility and benefits of using this synthetic cationic peptide as alternative to, or in combination with, traditional antibiotics to treat infections caused by MDR bacteria.
Improved detection of differentially represented DNA barcodes for high-throughput lineage phenomics
Authors: Akimov Yevhen , Bulanova Daria , Timonen Sanna , Wennerberg Krister , Aittokallio Tero 
Published: August 2019

AbstractCellular DNA barcoding has become a popular approach to study heterogeneity of cell populations and to identify lineages with differential response to cellular stimuli. However, there is a lack of reliable methods for statistical inference of differentially responding lineages. Here, we used mixtures of DNA-barcoded cell pools to generate a realistic benchmark read count dataset for modelling a range of outcomes of lineage-tracing experiments. By accounting for the statistical properties intrinsic to the DNA barcode read count data, we implemented an improved algorithm that provides a significantly higher accuracy at detecting differentially responding lineages, compared to current RNA-seq data analysis algorithms. Building on the reliable statistical methodology, we illustrate how multidimensional phenotypic profiling (or high-throughput ‘lineage phenomics’) enables one to deconvolute phenotypically distinct cell subpopulations within a cancer cell line. The mixture control dataset and our analysis results provide a systematic foundation for benchmarking and improving algorithms for lineage-tracing experiments.
Post-Transcriptional Bone Morphogenetic Protein 2 (BMP2) Gene Regulation in Aorta
Authors: Shah Tapan A. , Tang Ying , Yurkow Edward J. , Rogers Melissa B. 
Published: August 2019

AbstractDeletion of an “ultra-conserved sequence” (UCS) within theBone Morphogenetic Protein (Bmp)2mRNA previously revealed that the sequence repressesBmp2reporter gene expression in vascular cells. The objective was to determine the impact of the endogenous UCS onBmp2mRNA levels, BMP signaling, and calcification in the healthy control aorta and in the calcified aorta of mice with renal disease. We compared the phenotypes of mice bearing a wild typeBmp2allele or the UCS deletion allele in mice with normal kidney function or inKlothomutant mice with reduced kidney function. BMP signaling and calcium levels were normally higher in control females relative to males. UCS deletion induced aorticBmp2mRNA and BMP signaling in control males, but not in females. UCS deletion significantly increased BMP signaling in both male and femaleKlothohomozygotes. Inheritance of theBmp2UCS deletion andKlothoalleles was skewed from Mendelian expectations suggesting that these alleles influence interacting pathways. Analyses of body and heart weight supported these interactions. TheBmp2UCS represses BMP signaling in control males and in mice of both sexes with abnormal mineralization associated with kidney disease. Disease and sex-specific differences inBmp2gene control may influence the onset and progression of cardiovascular diseases.
Understanding the intention to use commodity futures contracts
Authors: Michels Marius , Möllmann Johannes , Musshoff Oliver 
Published: August 2019

PurposeAdoption rates of commodity futures contracts among farmers are rather low in Europe despite their political support. The purpose of this paper is to examine whether the Technology Acceptance Model (TAM) can contribute to the understanding of farmers’ intention to use commodity futures contracts. Here, the authors explicitly distinguish between usage motives for price risk reduction and speculation.Design/methodology/approachThe study is based on an online survey with 134 German farmers using partial least squares structural equation modeling to estimate the TAM.FindingsThe intention to use commodity futures contracts is mostly driven by farmers’ motivation for speculation rather than price risk reduction. Assuming risk averse farmers, this result could explain low adoption rates. Furthermore, perceived ease of use has a positive effect on the intention to use commodity futures contracts.Practical implicationsHandling of price hedging instruments should be facilitated to increase farmers’ adoption. Effective marketing trainings, which can demonstrate the ability of commodity futures contracts to reduce price risk, could increase farmers’ motivation to use them for their risk management instead of speculation.Originality/valueThis study analyzes path relationships between constructs expected to influence the intention to use commodity futures contracts which are allowed to be estimated by the TAM in one model. Here, the authors explicitly distinguish between usage motives for price risk reduction and speculation. This is the first study applying the TAM to price risk management tools.
Reconceptualization of the usefulness of a system as a multidimensional construct geared towards supporting tasks
Authors: Bravo Edgardo 
Published: August 2019

PurposeThe purpose of this paper is to develop a theory and provide empirical support for the re-conceptualization of usefulness as a multidimensional construct based on the technological roles of automation and computerization.Design/methodology/approachA non-experimental transverse design is followed. Data were gathered using a questionnaire. The participants were users of enterprise resource planning systems. The analysis technique used was the structural equation model.FindingsResults show that the proposed conceptualization has empirical grounding as well as sufficient predictive validity.Research limitations/implicationsThe empirical evaluation was developed using only one type of information system (IS).Originality/valueThis study expands on the existing literature by proposing and empirically evaluating a multidimensional conceptualization of usefulness to try to clarify how a system is useful and, once a greater granularity of usefulness is established, helping to improve the design and construction of information systems.
Process improvement in a radiology department
Authors: Camgoz-Akdag Hatice , Beldek Tuğçe 
Published: August 2019

PurposeThe purpose of this paper is to improve the mammography and ultrasound screening processes to increase the healthcare system quality and patients’ pleasantness while decreasing costs.Design/methodology/approachThe data storage system is very insufficient so that data are collected from hospital staff and by personal observations. A lean management tool, value stream mapping is used to see the general view of the radiology department with its problems at a glance. Data and the map are used as a guide to conduct a quality house to make a prioritization between the problems, to decide which one to solve first, of patients at the hospital.FindingsProblems of the radiology department related to mammography and ultrasound and suggestions to these problems according to the quality house conducted.Originality/valueThe paper consequently focuses on the value creation process and on how to revisit managing for quality in the systems perspective.
Numerical simulation for transient flow of Williamson fluid with multiple slip model in the presence of chemically reacting species
Authors: Hamid Aamir , Khan Masood , Alghamdi Metib 
Published: August 2019

Purpose
The purpose of this paper is to analyze a mathematical model for the time-dependent flow of non-Newtonian Williamson liquid because of a stretching surface. The mathematical formulation of the current model is accomplished from the momentum, energy and concentration balances by assuming a laminar, two-dimensional and incompressible flow subjected to a variable magnetic field. The study further aimed at discovering the possible effects of temperature-dependent thermal conductivity on the heat transfer characteristics.

Design/methodology/approach
In addition, a first-order chemical reaction is considered between the fluid and chemically reacting species. The governing transport model for Williamson fluid has been altered to ordinary differential equations via appropriate dimensionless parameters. These basic non-dimensional partially coupled differential equations of fluid motion are solved by an efficient Runge–Kutta–Fehlberg integration scheme along with the Nachtsheim–Swigert shooting technique.

Findings
It is found that the velocity slip parameter has a reducing impact on the skin friction coefficient. Moreover, we noticed that the Hartmann number and variable thermal conductivity parameters show prominent impacts on the velocity and temperature fields. It is also perceived that the fluid temperature shows an increasing trend with uplifting values of variable thermal conductivity.

Originality/value
No such work is yet published in the literature.
Do vocational high school graduates have better employment outcomes than general high school graduates?
Authors: Torun Huzeyfe , Tumen Semih 
Published: August 2019

Purpose
The purpose of this paper is to estimate the causal effect of vocational high school (VHS) education on employment likelihood relative to general high school (GHS) education in Turkey using Census data.

Design/methodology/approach
To address non-random selection into high school types, the authors collect construction dates of the VHSs at the town level and use various measures of VHS availability in the town by the age of 13 as instrumental variables.

Findings
The first-stage estimates suggest that the availability of VHS does not affect the overall high school graduation rates, but generates a substitution from GHS to VHS. The OLS estimates yield the result that individuals with a VHS degree are around 5 percentage points more likely to be employed compared to those with a GHS degree. When the authors use measures of VHS availability as instruments, they still find positive and statistically significant effect of VHS degree on employment likelihood relative to GHS degree. However, once they include town-level controls or town fixed effects, IV estimates get much smaller and become statistically insignificant.

Originality/value
The authorsconclude that, although VHS construction generates a substitution from GHS to VHS education, this substitution is not transformed into increased employment rates in a statistically significant way.
Reducing global supply chains’ waste of overproduction by using lean principles
Authors: Chen Chi-Kuang , Palma Fernando , Reyes Lidia 
Published: August 2019

Purpose
This paper aims to present a lean management approach to reduce waste generated by overproduction within a global supply chain setting. Statistics register a considerable increase in inventories which has increased waste because of the overproduction/oversupply throughout the global supply chain, and there has been insufficient research targeting on it.

Design/methodology/approach
This study develops a conceptual approach based on the practices of Toyota Production System (TPS). The analysis is performed on four segments of a business: “R&D”, “Production”, “Logistics” and “Service/retailers”. The proposed approach adopts the pull-based lean management system by two modules, “Intra-lean management” and “Inter-lean management”.

Findings
A case study is conducted to demonstrate how the proposed approach can be used in a real situation. The ideas and benefits of the proposed approach are also discussed.

Practical implications
The proposed solution can be applied in manufacturing and service industries, as well as in industries where production and R&D are interconnected.

Originality/value
The paper provides a conceptual approach that explains how intra- and inter-lean management can be effectively integrated to achieve a smooth flow in the business. This paper innovates in developing a pull-based driven flow relationship among the four segments of a business, as a response to the lack of integration among them and the increase of inventory in the hands of businesses.
Design of a logistics performance management system based on the system dynamics model
Authors: Irfani Dian Prama , Wibisono Dermawan , Basri Mursyid Hasan 
Published: August 2019

Purpose
Logistics systems used in companies that perform multiple roles are expected to be able to manage conflicting objectives. Nevertheless, the literature suggests that many existing logistics performance measurement system (PMS) frameworks are not optimized to provide mechanisms to reveal dynamic relationships between conflicting performance indicators. The purpose of this paper is to develop a new logistics PMS by linking the system dynamics model with a set of balanced performance indicators.

Design/methodology/approach
The logistics PMS is developed through a literature review and case study of a company that plays multiple roles. The interrelationships between logistics factors and their links to end results are modeled in diagrams through in-depth interviews with stakeholders. The developed model is then used to build a simulation tool to analyze factors that cause poor performance.

Findings
The new logistics PMS developed by incorporating system dynamics offers decision makers ways to identify dynamic relationships among factors and conflicting indicators, in turn helping them to understand holistic logistics performance, objectively analyze why logistics systems perform in a certain way and foster a common shared view.

Practical implications
Stakeholders of companies that play multiple roles can use the new PMS model to comprehensively evaluate the performance of logistics systems. In addition, the increased visibility of logistics systems may support decision-making while preventing local optimization.

Originality/value
A logistical PMS based on the system dynamics model for managing logistics systems in companies performing multiple roles has not yet been identified. This paper fills this theoretical gap and contributes to the academic literature by proposing a novel PMS model based on the system dynamics model to address the limitations of existing PMS frameworks.
Cross-impact of leverage and firm performance: developed vs frontier bank-based economies
Authors: Mishra Sibanjan , Dasgupta Ranjan 
Published: August 2019

Purpose
The purpose of this paper is to investigate the cross-impact of leverage and performance for firms operating in the developed and frontier bank-based economies.

Design/methodology/approach
This study uses annual panel data for a sample of 400 firms over a period of 27 years from 1990 to 2016. The sample sample firms consist of developed, Germany, France and Japan, and frontier including Argentina and Sri Lanka bank-based economies firms. The authors employ a simultaneous equation modeling consisting of two equations estimated using the two-stage least squares procedure to examine the cross-relationships between leverage and performance after controlling for other firm-level variables like size, growth and liquidity.

Findings
The empirical results are presented in two sets. First, in the case of firms in the developed bank-based sample, the authors find a negative debt-to-performance relationship and a negative performance-to-debt relationship. This inconsistent negative debt–performance relationship implies that firms operating in these economies use debt beyond a threshold limit, which, in turn, increases agency issues between the managers and debt-holders, thereby influencing firm performance adversely. Second, for frontier economies firms, the authors find a positive debt-to-performance relationship in line with the “trade-off theory.” Furthermore, the authors find a negative performance-to-debt relationship for both sub-samples in line with the “pecking-order theory.”

Originality/value
The study is distinct from earlier empirical studies and contributes largely to the existing literature. First, it emphasizes whether financial leverage influences firm performance in bank-based economies as firms operating in such systems are exposed directly to the strict regulatory environment. Second, it investigates whether any reverse relationship emanating from firm performance to capital structure holds for firms of these countries. This issue, to the best of author knowledge, is unanswered in previous research, more specifically for developed and frontier bank-based economies. Moreover, the results are relevant, as firm managers, analysts and policymakers must consider the importance of such cross-debt-performance relationships, while determining the optimal capital structure, in the bank-based economies.
Editorial: it is not a wide‐open field for incretins ‐ collateral benefits favour the use of metformin in advanced non‐alcoholic steatohepatitis
Authors: Ratziu Vlad , Pais Raluca 
Published: August 2019

LINKED CONTENT
This article is linked to Vilar‐Gomez paper. To view this article, visit https://doi.org/10.1111/apt.15331.
A 24‐year experience of autologous stem cell transplantation for light chain amyloidosis patients in the United Kingdom
Authors: Sharpley Faye A. , Petrie Aviva , Mahmood Shameem , Sachchithanantham Sajitha , Lachmann Helen J. , Gillmore Julian D. , Whelan Carol J. , Fontana Marianna , Martinez-Naharro Ana , Quarta Cristina , Hawkins Philip N. , Wechalekar Ashutosh D. 
Published: August 2019

SummaryAutologous stem cell transplantation (ASCT) is considered to be the best method to achieve deep haematological/organ responses and improve survival in selected patients with AL amyloidosis. This field has been led by US centres and is less utilised in Europe. The introduction of effective chemotherapy agents for AL prompted us to re‐evaluate UK outcomes of ASCT in affected patients. A total of 264 AL amyloidosis patients treated with an ASCT between 1994 and 2018 were identified. Patient baseline characteristics, transplant‐related mortality (TRM) and overall survival (OS) were analysed. The median OS post‐ASCT was 87 months [95% confidence interval (CI): 77–106 months]. The median time from ASCT to next treatment was 48 months (95% CI: 29–55 months). A haematological response was achieved in 94·8% of patients and was a strong predictor of time to next treatment [P < 0·0001, hazard ratio (HR) = 1·75, 95% CI = 1·35–2·28] and OS (P = 0·007, HR = 1·91, 95% CI = 1·19–3·07). Organ response was: cardiac (n = 28, 60·9%), renal (n = 101, 76%) and liver (n = 7, 13·5%). Overall TRM was 8·7%, with a significant reduction over time (1994–2000: 18·8%; 2001–2006: 13·6%; 2007–2012: 6·2%; 2013–2018: 1·1%). In conclusion, ASCT is significantly safer and remains a highly effective treatment with excellent long‐term survival; it should be more widely considered as a treatment option for systemic AL amyloidosis.