bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA and transcriptomic analysis of fetal membrane revealed potential targets involved in oligohydramnios
Authors: Ou Yu-hua , Liu Yu-kun , Zhu Li-qiong , Chen Man-qi , Yi Xiao-chun , Chen Hui , Zhang Jian-ping 
Published: August 2019

Abstract
The challenge of oligohydramnios study is multiple causes of oligohydramnios. Long noncoding RNAs (lncRNAs) is a set of RNAs that has been proved to function in multiple biological process. Currently, little is know about their expression and possible role in oligohydramnios. Total RNA was isolated from fetal membranes ressected from oligohydramnios pregnant women (OR) and normal amniotic fluid control (Normal).RNA-sequencing (RNA-seq) obtain that a total of 801 lncRNAs and 367 mRNAs were differentially expressed in OR. Of which, 638 lncRNAs and 189 mRNAs were upregulated, and 163 lncRNAs and 178 mRNAs were downregulated. Of these lncRNAs, 566 of them were intergenic lncRNA, 351 were intronic antisense lncRNA，and 300 natural antisense. The differentially expressed lncRNA were primary located in chromosome 2, 1 and 11. KEGG enrichment pathways revealed the differential expressed mRNAs were enriched in pathway in cancer, Ras signaling pathway, TNF signaling pathway, focal adhesion, and chemokine signaling pathway. The qRT-PCR result confirmed that LINC00515 and RP11-388P9.2 were upregulated in OR. Furthermore, the constructed lncRNA-miRNA-mRNA regulatory network revealed TNR, CFTR, ABCC2, ABCA12, and COL9A2 as the candidate targets of LINC00515 and RP11-388P9.2. A wide range of lncRNAs were alert in OR, in particularly, LINC00515 and RP11-388P9.2 were confirmed to be uprgulated in OR, and their predicted downstream targets were transport and tissue growth and development associated. Further study focused on the role of differential expressed lncRNAs such as LINC00515 and RP11-388P9.2 would provide more insight into the pathophysiology in OR.
Microbiological quality and safety of Ready- to- eat foods from restaurants and food establishments in Yirgalem town Southern, Ethiopia
Authors: Arficho Tsegaye Shamebo , Kebede Asefa Hamato 
Published: August 2019

Abstract
Background: Foodborne illnesses are considered as one of the most important public health problems particularly in developing countries like Ethiopia. This study aimed to determine the microbiological quality and safety of ready-to-eat foods in Yirgalem town, southern Ethiopia from November 2016 to August 2017. Methods: The collection of ready-to-eat food samples and laboratory-based microbiological analysis was used as the study design. A total of 160 food samples comprising of 40 ‘Injera firfir’, 40‘Bayeaynet’, 40 Vegetables and 40 Spaghetti were collected and analyzed for microbial contamination following standard microbiological methods. Ten grams of each food sample was transferred into 90 ml of buffered peptone water and homogenized for 5 minutes using a vortex mixer. The homogenates were serial diluted up to 10-7 and a volume of 0.1ml aliquot was spread plated on pre-solidified media of Aerobic plate count agar, MacConkey agar, Mannitol salt agar, and Salmonella-Shigella agar and incubate at 35-37oc for 24 hrs. Also, Potato Dextrose Agar was used for the isolation of fungi. Data were entered into Microsoft Excel and analyzed using SPSS version 20.0. Results: All the collected food samples were subjected to total aerobic mesophilic bacteria, Coliform bacteria, Enterobacteriaceae, Staphylococcal, Yeasts, and Molds counts. Accordingly, the mean counts expressed as log10 CFU/g of food for each group of the organism were 7.90 ± 0.71, 4.31±1.30, 4.32 ± 1.30, 6.70 ± 0.34 and 4.5 ± 1.01, respectively. The highest bacterial load 162(28.9%) was detected in ‘Injera firfir’ whereas the lowest 108(19.2%) case was investigated in Spaghettis. Regarding the food safety issue, the frequency of S. aureus, E. coli and Salmonella spp in the food samples were 54.4%, 43.8%, and 0.6%, respectively. Conclusion: The high microbial load and existence of foodborne pathogens in ready-to-eat foods in Yirgalem town, Southern Ethiopia is calling for the creation of awareness among restaurant and food establishment owners and food handlers concerning the hygienic practice.
Keyword: Microbial quality, Yirgalem town, Southern Ethiopia
Access to cataract services in selected rural communities in South Africa
Authors: Khoza Lunic Base , Nunu Wilfred Njabulo , Manganye Bumani Solomon , Mambanga Pfungwa , Tshivhase Shonisani , Murwira Tinotenda Success , Ramakuela Nditsheni , Ndou Nthomeni 
Published: August 2019

Abstract
Background Despite government efforts to improve access to health care services through the re-engineered Primary Health Care and National Health insurance platform, access still remain a challenge particularly in rural areas. The aim of this study was to analyse secondary data on cataract patients who were attended to in selected hospitals in rural Limpopo of South Africa. Methodology A cross section survey was conducted on 411 patient records from five selected hospitals in Vhembe district. A pre tested structured checklist was used to guide retrieval of variables from patient records. The collected data was entered into excel spreadsheet, cleaned and imported into Statistical Package for Social Sciences version 26 for analysis. Proportions of demographic characteristics were presented and these were cross tabulated with the outcome variable “success of operation” using Chi Squared tests. Results Findings point out that majority of patients who attended hospital for eye services were aged 65 years above and females (63%). There was no association between the tested demographic characteristics and the outcome variable. Most patients were diagnosed in the period 2015-2018 (60%). Over 90% of those that were operated had successful operations. Of the remaining 10% that had unsuccessful operations, 30% cited complications as being the reason why these operations were unsuccessful. Conclusions It is evident from the findings that cataract services offered in rural areas have low impact as they are not accessible to the patient. It is critical to have a worker retention strategy to retain experts.
Short-term Results Of Sclerotherapy With 3% Polidocanol Foam For Symptomatic Second- And Third-degree Haemorrhoidal Disease
Authors: Lobascio Pierluigi , Laforgia Rita , Novelli Eugenio Novelli , Perrone Fabrizio , Salvo Maria Di , Pezzolla Angela , Trompetto Mario , Gallo Gaetano 
Published: August 2019

Abstract
Background.Haemorrhoidal disease (HD) is defined as the symptomatic enlargement and/or distal displacement of anal cushions and is one of the most common proctological diseases. Sclerotherapy (ST) with 3% polidocanol foam induces an inflammatory reaction with sclerosis of the submucosal tissue and consequent suspension of the haemorrhoidal tissue. The aim of this study was to evaluate the short-term effectiveness and safety of ST with 3% polidocanol foam for the treatment of symptomatic second- and third-degree HD. Methods.A total of 66 patients with symptomatic second- and third-degree HD underwent a single ST session between March 2017 and July 2018. A visual analogue scale score was used to assess post-operative pain and patient satisfaction. The symptoms severity and anal continence were investigated through a self-reported questionnaire and Vaizey score, respectively, at baseline, at 4 weeks and after 1 year. Results. Fifty-seven out of 66 patients were male (86.3%), and the mean age was 52 (29-75; SD ± 12) years. The mean operative time was 4.5 (2-6; SD ± 1.23) minutes. No intraoperative complications and no drug-related side effects occurred. The overall success rate was 78.8% (52/66 patients) after a single ST session and 86% after two ST sessions (57/66 patients). The mean treatment effect, obtained comparing preoperative and T5 symptom scores in each patient, showed a mean change of 7.88 (p<0.001). All patients resumed their normal daily activities the day after the procedures. Conclusions.ST with 3% polidocanol foam is a safe, cost-effective and repeatable conservative treatment.
Building literacies in secondary school history: The specific contribution of academic writing support
Authors: Breeze Ruth , Gerns Jiménez-Villarejo Pilar 
Published: August 2019

This paper considers the specific role and effect of academic writing support in a secondary school Content and Language Integrated Learning (CLIL) context. After discussing the potential place for academic writing support in the ongoing process of fostering disciplinary literacy, we report on an experimental study in which 45 Spanish secondary school students received a short academic writing module as part of their history course. The descriptions/explanations written in their post-tests were generally found to be more complete, with more explicit discourse markers and with better textual organization than the pre-tests. We discuss the implications of this for students’ progress towards disciplinary literacy.
Effect of Cover Crop Termination Timing on Pools and Fluxes of Inorganic Nitrogen in No‐Till Corn
Authors: Otte Briana , Mirsky Steven , Schomberg Harry , Davis Brian , Tully Katherine 
Published: August 2019

Cover crops are increasingly used around the world to enhance N cycling and provide a suite of agroecosystem benefits. The N scavenging capacity of cover crops during winter months is well recognized. Our research characterized spring management effects (e.g., early vs. late termination) on cover crop biomass, decomposition and N release rates, inorganic soil N, soil water dynamics, and corn (Zea mays L.) performance. Cereal rye (Secale cereale L.) was established in Beltsville, MD, to evaluate three management scenarios: no cover crop; early termination (∼40 d before corn planting); late termination (∼7 d before corn planting). Cereal rye biomass was quantified before termination, and decomposition was tracked over a 24‐wk period to assess loss. Soil N content to 100 cm, soil volumetric water content, and corn performance were evaluated over the corn growing season. Low spring precipitation in 2016 led to similar amounts of cereal rye biomass for early and late termination; however, late‐terminated cereal rye had lower quality biomass (higher C/N) in both years, leading to slower decomposition and N release rates. Over the corn growing season, late‐terminated cereal rye consistently had smaller soil N pools, suggesting more efficient N cycling (better synchrony of N release from cover crop residues with corn N demand) than early‐terminated cover crops. Corn yields were smallest following late‐terminated cereal rye in 2016, but there was no difference in yields among cover crop treatments in 2017. Overall, we conclude that planting cereal rye cover crops and delaying termination until later in the season will help retain and efficiently cycle N while maintaining high corn yields.Core Ideas

We tested the effect of cover crop termination timing on N dynamics before corn.
Late‐terminated cereal rye had slower rates of biomass loss and N release.
Larger soil N pools in 2017 than 2016 resulted from lower corn yields.
Cover crop biomass and corn performance were influenced by precipitation levels.
Nitrogen was more efficiently cycled in systems with cover crops than systems without cover crops.
Antimony(III/V) removal from industrial wastewaters: treatment of spent catalysts formally used in the SOHIO acrylonitrile process
Authors: Foster Richard I. , Oh Maeng-kyo , Yang Dasom , Shon Woo-Jung , Kim Kwang-Wook , Lee Keun-Young 
Published: August 2019

Abstract
A treatment and volume reduction process for a spent uranium–antimony catalyst has been developed. Targeted removal, immobilization and disposal of the uranium component has been confirmed, thus eliminating the radiological hazard. However, significant concentrations of antimony ([Sb] ≥ 25–50 mg L−1) remain in effluent from the process, which require removal in compliance with Korean wastewater regulations. Antimony(III/V) removal via co-precipitation with iron has been considered with optimal pH, dose and kinetics being determined. The effect of selected anions – Cl−, SO42− and PO43− – have also been considered, the latter present due to a prior uranium removal step. Removal of Sb(III) from both Cl− and SO42− media and Sb(V) removal from Cl− media to below release limits were found to be effective within 5 minutes at an iron dose of 8 mM (molar ratio, [FeIII]/[Sb] = 20) and a target pH of 5.0. However, Sb(V) removal from SO42− was significantly hampered requiring significantly higher iron dosages for the same removal performance. Phosphate poses significant challenges for the removal of Sb(V) due to competition between PO43− and Sb(OH)6− species for surface binding sites, attributed to similarities in chemistries and a shared preference for an inner vs outer binding mechanism.
Pathophysiology and Management of Atopic Dermatitis: A Laconic Review
Authors: Kumar Pravin , Sharma Dinesh Kumar , Ashawat Mahendra Singh 
Published: August 2019

Conclusion:Atopic Dermatitis (AD) is long-lasting degenerating skin disease with a characteristic phenotype and stereotypically spread skin lesions. The AD results due to a complex interface among genetic factors, host’s surroundings, pharmacological anomalies and immunological factors. In previous decades, researchers had shown marked interest due to increased prevalence in developed countries. In this review, basics along with the advances in pathogenesis and management of AD have been discussed. The immunological factors i.e. Innate Lymphoid Cells, IL-22 and Toll-like receptors have an important role in the pathogenesis. The proactive topical therapy by skincare, topical glucocorticosteroids and calcineurin inhibitors have improved effect in the management of AD. The human monoclonal antibody-based systemic drug (Duplimab) is a considerable advancement in the management of AD. Other monoclonal antibody-based drugs (Lebrikizumab, Tralokinumab, Apremilast and Nemolizumab) are in different phases of clinical trials. A better understanding of genetics and immunoregulatory cascade will lead to the development of efficacious drugs and better management therapy preventing the relapse of flares and improved life quality of AD patients.
Rare Earth Doped Hydroxyapatite Nanoparticles for In Vitro Bioimaging Applications
Authors: Zantye Pranjita , Fernandes Fiona , Ramanan Sutapa Roy , Kowshik Meenal 
Published: August 2019

:
Fluorescence based bioimaging is one of the widely used method
for obtaining imperative information on life processes.

Objective:
Within the expansive spectrum of fluorescent agents being investigated, the trivalent
Lanthanide (Ln) ion based nanoparticles have attracted attention due to their intrinsic
luminescence property.

Methods:
Here we report a modified sol gel assisted synthesis of Europium (Eu) and Samarium
(Sm) doped Hydroxyapatite nanoparticles (HAp NPs). Doping Ln ions in the selffluorescent
hydroxyapatite lattice contributed towards an increased luminescence in the
NPs.

Results:
The XRD patterns reveal that the Eu+3 and Sm+3 doped HAp NPs display the
characteristic peaks of hydroxyapatite in a hexagonal lattice structure, and the FTIR data
confirms presence of characteristic functional groups. The as-synthesized HAp NPs exhibit
short rod-shaped morphology with average length less than 60 nm. Upon excitation at representative
wavelengths, the doped HAp NPs demonstrated characteristic emission lines of
Eu+3 and Sm+3.

Conclusion:
The as-synthesized NPs displayed no toxicity towards HeLa cells and are
easily internalized, exhibiting their potential as promising live cell bioimaging agents.
SENDİKA TEMSİLCİLERİNİN LİDERLİK TUTUM VE DAVRANIŞLARININ SENDİKAL BAĞLILIK ÜZERİNE ETKİSİ SAKARYA İLİ ÖRNEĞİ
Authors: YILMAZ Tuncay , KİŞİOĞLU Hilal 
Published: August 2019

Amaç: Sakarya’da faaliyet gösteren kamu
eğitim kurumlarındaki iş yeri sendika temsilcilerinin liderlik davranış
özelliklerinin üyelerin sendikal bağlılıkları üzerindeki etkisinin
belirlenmesidir. Yöntem: Sakarya genelinde kamu kurumlarında görev yapan okul öncesi, ilkokul,
ortaokul ve lisede görevli Eğitim Bir-Sen, Türk Eğitim-Sen ve Eğitim-Sen
sendikalarına üye öğretmenler üzerinde bir araştırma yapılmıştır. Araştırmada veri
toplama aracı olarak araştırmanın amacı doğrultusunda hazırlanan anket formu
kullanılmış ve yüz yüze görüşme yoluyla 380 sendika üyesi öğretmene anket
uygulanmıştır.
Araştırma
sonucunda elde edilen verilerin analizinde SPSS 24.0 programı
kullanılmıştır. Elde edilen veriler,
analiz edilirken frekans, ortalama, yüzde alma, faktör analizi, korelasyon ve
basit regresyon analiz yöntemleri kullanılmıştır.Bulgular: Araştırma
bulgularından hareketle işyeri sendika temsilcilerinin özellikleri şu
şekildedir: arkadaş canlısı, diğerlerinin fikir ve önerilerini dinleyen, astlarına güvenen, karar alırken riske
girmekten kaçınmayan, her işi kendisi yapmaya çalışan, kimin neden sorumlu
olduğunu her zaman bilen, başkalarına görev ve sorumluluk vermekten kaçınmayan,
açık ve dürüst bir yöntemi olan, tutarlı, eleştirilere açık, yeni fikirleri
tartışmaktan hoşlanan, kurallara ve prensiplere uymaya önem veren, iyi
çalışmaları takdir eden, amaçları belirgin, yeni projeler üreten, uygulanmakta
olan planlar üzerinde çok titiz, astlarını savunan, yeniliklere açık,
çatışmaları ortadan kaldıracak olanaklar yaratan, astlarına adil davranan,
gerektiğinde çabuk karar alan, planları dikkatli yapan, karar verirken
astlarına söz hakkı veren, esnek ve değişime açık olmalarıdır. İş yeri sendika temsilcilerinin bu liderlik
özelliklerinin üyelerin sendikal bağlılıkları üzerinde etkisi bulunmaktadır.

Sonuç: İşyeri
sendika temsilcilerinin liderlik davranış özelliklerinin üyelerin sendikal
bağlılıkları üzerinde etkisi olduğu ortaya çıkmıştır.
PERPINDAHAN FRASA NOMINA BENEFACTIVE KE ARGUMENT-POSITION DALAM KALIMAT PASIF BITRANSITIF PADA RAGAM BAHASA LISAN ANAK USIA PRASEKOLAH
Authors: Prihatini Arti 
Published: August 2019

Penelitian ini bertujuan menelaah perpindahan frasa nomina (FN) benefactive ke Argument-Position (A-Position) pada kalimat pasif bitransitif tanpa delisi pada anak usia prasekolah. Pendekatan penelitian ini adalah kualitatif. Jenis penelitian ini adalah studi kasus deskriptif. Data penelitian ini adalah perpindahan FN ke A-Position pada kalimat pasif bitransitif tanpa delisi yang bersumber dari tuturan lisan anak usia prasekolah di Kelas B-Lion TK Laboratorium UM. Pengumpulan data dilakukan dengan teknik perekaman dan catatan lapang. Analisis data terdiri atas tiga tahap, yaitu reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa anak usia prasekolah dapat memindahkan frasa nomina benefaktif ke argument-position dengan disertai penyesuaian berupa perubahan imbuhan verba aktif menjadi verba pasif yang berimbuhan di-. Anak juga mempertimbangkan kebernyawaan (animacy) dalam proses perpindahan frasa nomina benefactive dan dalam penyusunan urutan kata dalam kalimat hasil perpindahan tersebut. Perpindahan yang dilakukan tidak melanggar subjacency condition.
TURN-TAKING MARKER ETHNICAL BUGIS AND BETAWI AT INDONESIAN CONVERSION IN INDONESIA
Authors: Juanda Juanda - , Aziz Aziz 
Published: August 2019

Abstract.The conversation uses marker’s in the turn-taking. Turn-taking for participants has characteristics based on cultural backgrounds for the ethnically involved as participants. The purpose of this research is to analyze the interaction in the conversation and turn -taking and its marker’s. This research is a descriptive research. This research was used the approach of conversation analysis. The sources of data were drawn from the oral dialogue of ethnic Betawi and Bugis ethnic groups. The data retrieval by recording technique. The data analysis using Flow Model (Miles and A. Michael Huberman). The results this research show the interaction of turn taking conversations in Bugis and Betawi ethnic groups was dominated by more senior speakers and who have extensive knowledge insight. More junior speakers have a minimum speech turn. Pause or silence is a long time going when the topic will change. Transition markers in turn-taking are generally greetings and calls like Hen, Hah, Iye, Kok, Yah, Hm., Aah, Kalogitu, Ok, Goodnoon Madam! Good Afternoon Mas !, Yes, That, Lho, Nih. These markers are influenced by native language and ethnic backgrounds of the participants. Keywords: Markers, turn-taking, Bugis, and Betawi
Songdo - smart and clean
Authors: Silva Paulo Celso , Prestes Júlio Dias 
Published: August 2019

Resultado de investigações, ainda em curso, acerca das smart cities, este artigo analisa as contradições de uma cidade idealizada como perfeita, a Smart city Songdo (Coreia do Sul). Para isso, definimos inicialmente o que as empresas compreendem por Smart city e adentramos para a reflexão dos territórios e Multiterritórios, a dialogar com as propostas teóricas de Haesbaert, Santos e com as propostas filosóficas de Lefebvre, nos temas do direito à cidade e a revolução urbana, os quais também recorremos aos geógrafos Edward Soja e David Harvey. Michel Serres nos apresenta suas análises do mal limpo de nosso período atual, no qual a sociedade assume outras formas de demarcação de territórios ao produzir lixo e resíduos e tenta livrar-se deles. Diante dessas colocações, entendemos Songdo como uma distopia do capital global.
Incidence of Type 2 Diabetes in People With a History of Hospitalization for Major Mental Illness in Scotland, 2001–2015: A Retrospective Cohort Study
Authors: Jackson Caroline A. , Fleetwood Kelly , Kerssens Jan , Smith Daniel J. , Mercer Stewart , Wild Sarah H. 
Published: August 2019

OBJECTIVE
To determine the incidence of type 2 diabetes in people with a history of hospitalization for major mental illness versus no mental illness in Scotland by time period and sociodemographics.

RESEARCH DESIGN AND METHODS
We used national Scottish population-based records to create cohorts with a hospital record of schizophrenia, bipolar disorder, or depression or no mental illness and to ascertain diabetes incidence. We used quasi-Poisson regression models including age, sex, time period, and area-based deprivation to estimate incidence and relative risks (RRs) of diabetes by mental illness status. Estimates are illustrated for people aged 60 years and in the middle deprivation quintile in 2015.

RESULTS
We identified 254,136 diabetes cases during 2001–2015. Diabetes incidence in 2015 was 1.5- to 2.5-fold higher in people with versus without a major mental disorder, with the gap having slightly increased over time. RRs of diabetes incidence were greater among women than men for schizophrenia (RR 2.40 [95% CI 2.01, 2.85] and 1.63 [1.38, 1.94]), respectively) and depression (RR 2.10 [1.86, 2.36] and 1.62 [1.43, 1.82]) but similar for bipolar disorder (RR 1.65 [1.35, 2.02] and 1.50 [1.22, 1.84]). Absolute and relative differences in diabetes incidence associated with mental illness increased with increasing deprivation.

CONCLUSIONS
Disparities in diabetes incidence between people with and without major mental illness appear to be widening. Major mental illness has a greater effect on diabetes risk in women and people living in more deprived areas, which has implications for intervention strategies to reduce diabetes risk in this vulnerable population.