bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acceptance of robo‐advisors: Effects of financial experience, affective reactions, and self‐enhancement motives
Authors: Hohenberger Christoph , Lee Chaiwoo , Coughlin Joseph F. 
Published: July 2019

AbstractRobo‐advisors have recently been gaining interest as a technology‐enabled means to make financial management easier. The aim of this study is to examine how people's self‐assessed financial experience, affective reactions, and the interplay with individual values influence their willingness to use a robo‐advisor. We argue that one's self‐assessed financial experience influences the willingness to use robo‐advisors as a result of different affective reactions (i.e., anxiety and joy) associated with its usage. We further posit that the mediating effect of anxiety varies with individual levels of a motivational factor—self‐enhancement—which has been found to regulate anxiety‐related feelings. Based on a large‐scale nationwide survey with an online sample of American adults, it was found that affective responses (i.e., anxiety and joy) explain (i.e., mediate) the effect of self‐assessed financial experience on the willingness to use robo‐advisor. Moreover, the mediating effect of anxiety was found to vary with levels of self‐enhancement motives. The findings suggest that willingness to use robo‐advisors may be increased with positive emotions (e.g., joy) expected from use, while decreased by anticipated negative emotions (e.g., anxiety), and that the relationship may be altered by inducing individuals' self‐enhancement motives (e.g., possibility of accumulating wealth).
Twenty cases of allergic contact dermatitis due to benzoyl peroxide in acne patients in Japan
Authors: Iijima Shigeruko , Tsunoda Takahiko 
Published: July 2019

AbstractBackgroundBenzoyl peroxide is a topical antiacne drug, which also acts as a strong irritant and a weak allergen. Only a few acne patients with allergic contact dermatitis due to benzoyl peroxide gel have been diagnosed by patch testing in Japan. Therefore, the number of such patients is probably underestimated.ObjectivesTo correctly diagnose such cases by patch testing and to determine their characteristics and frequency.Patients and methodsTwenty acne patients that were diagnosed with allergic contact dermatitis between April 2015 and April 2018 were enrolled in this study. Patch tests were performed with acne gels containing benzoyl peroxide and 1% benzoyl peroxide in petrolatum. The patients' profiles and the frequency of dermatitis were analyzed.ResultsAll of the patients were female, and their mean age was 24.1 ± 9.3 years. Two patients were suffering from atopic dermatitis. The onset of allergic contact dermatitis occurred at 1 to 2 days, 9 to 28 days, and >30 days (longest: up to 24 months) after the initial application of the causative substance in 3 patients, 9 patients, and 8 patients, respectively. The frequency of such cases was 4.5% at our clinic.ConclusionsBenzoyl peroxide gels for acne were demonstrated to often act as allergic contact allergens, and thus, dermatologists should be aware of their allergenicity and be apprehensive about markedly increasing the use of such gels in the future.
Plasma metabolites mediate the effect of HbA1c on incident cardiovascular disease
Authors: Dong Xuesi , Zhou Wei , Li Hu , Fan Yuanming , Yin Xiaojian , Li Yong , Chen Feng , Ma Gaoxiang 
Published: July 2019

AbstractBackgroundWe aim to discover whether HbA1c affects incident cardiovascular disease (CVD) through regulating endogenous metabolites.Methods and ResultsTotally, 2019 plasma samples were analyzed by liquid chromatography‐quadrupole time‐of‐flight mass spectrometry. Logistic regression and linear regression were used to screen metabolites which were associated with both CVD and HbA1c. The VanderWeele's mediation approach was performed to assess the direct effect and indirect effect (IE) in the counterfactual model. Forty‐eight metabolites showed an association with both HbA1c and CVD risk. Forty‐four of the 48 metabolites worked as mediators mediated in HbA1c's effect on CVD (odds ratio [OR]IE from 0.997 to 6.098, false discovery rate q < 0.05, mediated proportion from 0.4% to 85.4%). Pathway enrichment analysis indicated that different metabolic pathway showed significant IE (butanoate metabolism ORIE = 1.058, mediated proportion = 16.0%; alanine, aspartate and glutamate metabolism ORIE = 1.082, mediated proportion = 21.8%; TCA (citric acid) cycle metabolism ORIE = 1.048, mediated proportion = 13.8%; phenylalanine metabolism ORIE = 1.067, mediated proportion = 18.4%; glycerophospholipid metabolism ORIE = 3.007, mediated proportion = 82.2%; all the P < .01).ConclusionsOur findings suggest that metabolites mediate the effect of HbA1c on incident CVD and provide a new study sight into pathogenesis of CVD.
Virtual Pharmacophore Screening Identifies Small‐Molecule Inhibitors of the Rev1‐CT/RIR Protein–Protein Interaction
Authors: Dash Radha C. , Ozen Zuleyha , McCarthy Kaitlyn R. , Chatterjee Nimrat , Harris Cynthia A. , Rizzo Alessandro A. , Walker Graham C. , Korzhnev Dmitry M. , Hadden M. Kyle 
Published: July 2019

AbstractTranslesion synthesis (TLS) has emerged as a mechanism through which several forms of cancer develop acquired resistance to first‐line genotoxic chemotherapies by allowing replication to continue in the presence of damaged DNA. Small molecules that inhibit TLS hold promise as a novel class of anticancer agents that can serve to enhance the efficacy of these front‐line therapies. We previously used a structure‐based rational design approach to identify the phenazopyridine scaffold as an inhibitor of TLS that functions by disrupting the protein–protein interaction (PPI) between the C‐terminal domain of the TLS DNA polymerase Rev1 (Rev1‐CT) and the Rev1 interacting regions (RIR) of other TLS DNA polymerases. To continue the identification of small molecules that disrupt the Rev1‐CT/RIR PPI, we generated a pharmacophore model based on the phenazopyridine scaffold and used it in a structure‐based virtual screen. In vitro analysis of promising hits identified several new chemotypes with the ability to disrupt this key TLS PPI. In addition, several of these compounds were found to enhance the efficacy of cisplatin in cultured cells, highlighting their anti‐TLS potential.
Phenol‐Soluble‐Modulin‐Inspired Amphipathic Peptides Have Bactericidal Activity against Multidrug‐Resistant Bacteria
Authors: Zeng Ping , Xu Chen , Cheng Qipeng , Liu Jun , Gao Wei , Yang Xuemei , Wong Kwok‐Yin , Chen Sheng , Chan Kin‐Fai 
Published: July 2019

AbstractPhenol‐soluble modulins (PSMs) are a large family of cytolytic peptide toxins produced by Staphylococcus aureus. Based on their amino acid sequences, we have constructed a small library of cationic isoleucine‐rich peptides for antimicrobial evaluation. Relative to the parent PSMs, peptide zp3 (GIIAGIIIKIKK‐NH2) was found to possess greatly improved physicochemical properties (soluble in water) and antibacterial activity (MIC=8 μm for E. coli, B. subtilis, and C. freundii) while maintaining low hemolytic activity (<5 % at 256 μm) and cytotoxicity (HEK293 cells IC50>80 μm). We reasoned that the selective activity of zp3 toward bacterial cells is due to its amphiphilic nature and positive net charge. Moreover, it is difficult for bacteria to develop resistance against zp3. Through microscopic studies of E. coli, we demonstrated that zp3 can penetrate the bacterial membrane, thereby causing leakage of the bacterial cytoplasm. Our findings present a promising antimicrobial peptide lead, which has great potential for further chemical modification.
Discovery of Novel Biased Opioid Receptor Ligands through Structure‐Based Pharmacophore Virtual Screening and Experiment
Authors: Jeong Pyeonghwa , Kim Soo‐Kyung , Li Quanjie , Oh Su‐jin , Son Seonil , Chen Guangju , Tan Hongwei , Kim Siwon , Park Jong‐Hyun , Park Ki Duk , Kim Yeo Ok , Yoon Myung Ha , Kim Yong‐Chul , Goddard William A. 
Published: July 2019

AbstractGi‐protein‐biased agonists with minimal β‐arrestin recruitment represent opportunities to overcome the serious adverse effects of human mu opioid receptor (μ‐OR) agonists and developing alternative and safe treatments for pain. In order to discover novel non‐morphinan opioid receptor agonists, we applied hierarchical virtual screening of our in‐house database against a pharmacophore based on modeling the active conformations of opioid receptors. We discovered an initial hit compound, a novel μ‐OR agonist with a pyrazoloisoquinoline scaffold. We applied computational R‐group screening to this compound and synthesized 14 derivatives predicted to be the best. Of these, a new Gi‐protein‐biased compound, 1‐{5‐(3‐chlorophenyl)‐7,8‐dimethoxy‐3‐[4‐(methylsulfonyl)benzyl]‐3H‐pyrazolo[3,4‐c]isoquinolin‐1‐yl}‐N,N‐dimethylmethanamine, showed an EC50 value of 179 nm against the μ‐OR. This resulted in significant pain relief for mice in the phase II period of formalin response tests. This study provides a new strategy to identify diverse sets of promising compounds that might prove useful for the development of drugs that target other G‐protein‐coupled receptors.
Assessing the application of an image color appearance model to basic self‐luminous scenes
Authors: Phung Thanh Hang , Leloup Frédéric B. , Smet Kevin A. G. , Hanselaer Peter 
Published: July 2019

AbstractImage color appearance models (Image CAMs) have been developed to predict the perception of complex scenes and are mainly used for image rendering and video reproduction applications. Among these Image CAMs, iCAM is an Image CAM that takes an image as the input and provides the perceptual attributes for each pixel. On the other hand, nonimaging CAMs are widely used and validated, but they always assume a simple test scene of a uniform flat stimulus, a quasi‐neutral background, and a surround. This study presents an evaluation of the performance of iCAM when applied to these simple self‐luminous scenes in predicting the influence of background luminance, background size, saturation, and stimulus size on stimulus brightness. The results show that iCAM is capable of predicting the effect of background luminance and some background size scenarios. However, for unrelated self‐luminous stimuli (dark background), the model predictions do not match the reference data. An evaluation of the effect of the filter kernel size and its relation to the physiological mechanism of image processing inside the visual system has been investigated. Furthermore, the impact of saturation and stimulus size on brightness seems to be underestimated by the model, because the Helmholtz‐Kohlrausch and stimulus size effects are not included. Hence, these findings call for an enhanced Image CAM.
Direct Epiperimetric Inequalities for the Thin Obstacle Problem and Applications
Authors: Colombo Maria , Spolaor Luca , Velichkov Bozhidar 
Published: July 2019

We introduce a new logarithmic epiperimetric inequality for the 2m‐Weiss energy in any dimension, and we recover with a simple direct approach the usual epiperimetric inequality for the 3/2‐Weiss energy. In particular, even in the latter case, unlike the classical statements, we do not assume any a priori closeness to a special class of homogeneous functions. In dimension 2, we also prove for the first time the classical epiperimetric inequality for the (2m − 1/2)‐Weiss energy, thus covering all the admissible energies.As a first application, we classify the global λ‐homogeneous minimizers of the thin obstacle problem, with , showing as a consequence that the frequencies 3/2 and 2m are isolated and thus improving on the previously known results. Moreover, we give an example of a new family of (2m − 1/2)‐homogeneous minimizers in dimension higher than 2.Second, we give a short and self‐contained proof of the regularity of the free boundary of the thin obstacle problem, previously obtained by Athanasopoulos, Caffarelli, and Salsa (2008) for regular points and Garofalo and Petrosyan (2009) for singular points. In particular, we improve the C1 regularity of the singular set with frequency 2m by an explicit logarithmic modulus of continuity. © 2019 Wiley Periodicals, Inc.
A SDN‐based fine‐grained measurement and modeling approach to vehicular communication network traffic
Authors: Huo Liuwei , Jiang Dingde , Zhu Xiangnan , Wang Yuqing , Lv Zhihan , Singh Surjit 
Published: July 2019

SummaryIn smart cities, a large number of vehicles are connected into an intelligent transportation system and share information via the vehicular communication network (VCN). Accurate, fine‐grained, and comprehensive traffic measurements are very crucial for the controller's decision making in software‐defined networking (SDN) in VCN. Fine‐grained traffic measurements can accurately portray network behaviors for VCN. However, this will increase a large amount of measurement overhead. Therefore, how to effectively obtain accurate and fine‐grained traffic is a huge challenge for VCN. To the end, this paper proposes a novel accurate and SDN‐based fine‐grained traffic measurement approach to obtain comprehensive traffic in VCN. Firstly, based on SDN architecture, we exploit the pull‐based sampling mechanism to quickly obtain coarse‐grained traffic measurement values. Secondly, based on the matrix completion theory, we use both interpolation and optimization methods to obtain fine‐grained traffic measurements. Thirdly, the optimization model and detailed algorithm are proposed to attain accurate traffic. Finally, we conduct a larger number of simulations to validate the measurement approach proposed in this paper. Simulation results show that our approach exhibits better performance and is promising.
A directly seeking spectrum holes algorithm by compressive sampling
Authors: Zhao Hua , Wang Sheng , Li Lemin 
Published: July 2019

SummaryThe method of cognitive radio (CR) is a promising solution to the problem of spectrum scarcity. One of the crucial tasks in the CR is the spectrum hole (SH) detection. The energy detection (ED) method is the most dominant spectrum sensing approach owing to its low computational complexity and the ability to identify SHs without requiring a priori knowledge of primary transmission characteristics. But it will be accompanied by some problems such as the high sampling rates, the difficult setting for detection threshold, and the complexity. An improved algorithm with directly seeking SHs from compressive sampling via compressive sensing algorithm is proposed in this paper. The sampling rate is decreased by the process of the compressive sampling, and the computation complexity is reduced for the elimination of the construction stage in the proposed algorithm. Besides, the detection threshold is not needed to be set for the method of relative comparison. The simulation results show that the proposed algorithm has a similar probability of detection (POD) of SHs to the traditional ED algorithm and the compressive spectrum sensing algorithm with minimum sampling numbers and lower computation complexity on the condition that the signal noise ratio is beyond 0 dB. It means the proposed algorithm obtains the balance between computing complexity and the sampling rate, and the performance of SH detection is maintained at the same time.
Modified‐release oral pellets for duodenum delivery of doxycycline hyclate
Authors: Huang Ying , Huang Zhengwei , Wu Mingjun , Liu Yanpeng , Ma Cheng , Zhang Xuejuan , Zhao Ziyu , Bai Xuequn , Liu Hu , Wang Lili , Pan Xin , Wu Chuanbin 
Published: July 2019

AbstractTo minimize the gastric and esophageal injury effect, a system to deliver doxycycline hyclate (DOXY) to the duodenum area is needed. DOXY‐containing modified‐release oral pellets (DMOP) coated with hydroxypropyl methylcellulose phthalate HP‐55 (HPMCP HP‐55) and hydroxypropyl methylcellulose E15 (HPMC E15) appear to be a reasonable choice. This coating layer dissolves at pH 5.5, which is the pH of the duodenum, but not at a gastric pH (1.2). The formulation and preparation of DMOP were optimized, and a scale‐up test was performed. The results showed that the production reproducibility was acceptable, and the quality of DMOP well met the standards of Chinese Pharmacopeia (Ch.P, 2015 edition). Notably, the accumulated DOXY release was lower than 50% at pH 1.2 (20 min) and higher than 85% at pH 5.5, which met the USP40‐NF35 standard for DOXY modified‐release formulations. Moreover, the storage stability of DMOP with different packages was investigated by stress testing, accelerated and long‐term testings. The stability of DMOP was maintained up to 12 months, in terms of DOXY content and in vitro release behavior. The results seem to suggest that DMOP could be a promising duodenum delivery system.
Nonconsumptive effects of hunting on a nontarget game bird
Authors: Mohlman Jessica L. , Gardner Rachel R. , Parnell I. B. , Wilhite Nathan G. , Martin James A. 
Published: July 2019

Abstract

Human hunting activity and disturbance can significantly impact prey species through both consumptive and nonconsumptive effects. The nonconsumptive effects of rabbit hunting on Northern Bobwhite (Colinus virginianus; hereafter, bobwhite) are currently unknown. Increased perceived risk of predation by bobwhite during rabbit hunting events may elicit antipredator responses among bobwhite that impact fitness via changes in behavior that ultimately impact population growth.

We estimated the nonconsumptive effects of rabbit hunting on bobwhite behavior using telemetry across varying rabbit hunting intensities. Movements were analyzed using Bayesian hierarchical modeling with a before‐after‐control‐impact (BACI) design to determine the effect of rabbit hunting on bobwhite.

We observed an overall reduction in bobwhite movement in the presence of rabbit hunting, with a 38% (Posterior Overlap = 0.01) increase in bobwhite step length in the absence of rabbit hunting. We also observed bobwhite maintaining closer proximity to hardwood and escape cover under high rabbit hunting intensity, with a 59% (Posterior Overlap = 0.03) increase in distance from hardwood and a 28% (Posterior Overlap = 0.14) increase in distance from escape cover when rabbit hunting was removed.

Synthesis and applications. Heightened antipredator behavior through decreased movement may assist with bobwhite predator avoidance. However, decreased movement and increased use of poor habitats may also have negative effects as a result of reduced foraging time or increased susceptibility to other predators. Future research should attempt to quantify the effect of decreased movement on bobwhite fitness through the evaluation of foraging time and survival in order to continue to improve management efforts for the species.
The economic burden of heart failure in Denmark from 1998 to 2016
Authors: Bundgaard Johan S. , Mogensen Ulrik M. , Christensen Stefan , Ploug Uffe , Rørth Rasmus , Ibsen Rikke , Kjellberg Jakob , Køber Lars 
Published: July 2019

BackgroundHeart failure (HF) imposes a large burden on both the individual and the society. The aim of this study was to investigate the economic burden (either direct or indirect costs) attributed to patients with HF before, at, and after time of diagnosis.Methods and resultsUsing Danish nationwide registries we identified all patients > 18 years with a first‐time diagnosis of HF from 1998–2016 and matched them 1:1 with a control group from the background population on age, gender, marital status, and educational level. The economic analysis of the total costs after diagnosis was based on direct costs including hospitalization, procedures, medication, and indirect costs including social welfare and lost productivity to estimate the annual cost of HF. A total of 176 067 HF patients with a median age of 76 (interquartile range 67–84) years and 55% male were included. Patients with HF incurred an average of €17 039 in total annual direct (€11 926) and indirect (€5113) healthcare costs peaking at year of diagnosis compared to €5936 in the control group with the majority attributable to inpatient admissions. The total annual net costs including public transfer after index HF were €11 957 higher in patients with HF compared to controls and the economic consequences were evident more than 2 years prior to the diagnosis of HF.ConclusionPatients with HF impose significantly higher total annual healthcare costs compared to a matched control group with findings evident more than 2 years prior to HF diagnosis.
Synthesis of carborane acrylate and flame retardant modification on silk fabric via graft copolymerization with phosphate‐containing acrylate
Authors: Wu You , Liu Anqi , Li Wulong , Li Zhanxiong 
Published: July 2019

SummaryA novel carborane acrylate monomer (1‐acryloyloxyethyl carborane) was synthesized by addition reaction, hydrolysis, and esterification and characterized by proton nuclear magnetic resonance (1H NMR) spectroscopy and Fourier transform infrared spectroscopy (FT‐IR) analysis. Subsequently, the carborane monomer and a phosphate‐containing methacrylate monomer were applied on the modification of a silk fabric. The heat resistance and flame retardancy of the silk fabric before and after modification were compared. Energy‐dispersive X‐ray spectrometer (EDS) and FT‐IR showed that carborane monomer and phosphate‐containing methacrylate were grafted onto the surface of the fibers. The cross‐sectional morphology of silk fabrics after burning was observed by scanning electron microscope (SEM), and the flame‐retardant mechanism was analyzed. Thermal‐gravimetric analysis (TGA) and differential scanning calorimetry (DSC) analysis revealed that the thermal stability of the modified silk increased with the increase of the grafting yield. The MCC‐2 microcalorimeter (MCC) test showed that, when using 1‐acryloyloxyethyl carborane as monomer and blending with phosphate‐containing methacrylate, the maximum heat release rate (PHRR) of the modified silk fabric decreased from 97.6 W/g (before grafting) to 51.3 and 45.8 W/g, respectively, and the total heat release (THR) decreased from 10.2 kJ/g (before grafting) to 5.9 and 5.2 kJ/g, respectively. The limiting oxygen index (LOI) test revealed that using 1‐acryloyloxyethyl carborane and phosphate‐containing methacrylate as mixed monomers to modify the silk fabric obtained good flame retardancy, whose LOI value reached 29.8%.
Smarte Filter
Authors: Wessling Matthias 
Published: July 2019

AbstractSynthetische Membranen bieten eine wesentliche technologische Grundlage, um Wasser zu reinigen und aufzubereiten. Jetzt werden physikalische Modelle auch mit künstlicher Intelligenz gekoppelt. Das eröffnet auch der Trinkwasserversorgung neue Möglichkeiten.
Bomb Radiocarbon Age Validation of Warsaw Grouper and Snowy Grouper
Authors: Sanchez Phillip J , Pinsky Jeffrey P , Rooker Jay R 
Published: July 2019

Abstract
Current stock assessments for both the Warsaw Grouper Hyporthodus nigritus and the Snowy Grouper H. niveatus are based on age-structured population models determined using traditional otolith-based aging techniques. However, recent studies using bomb radiocarbon validation have shown that many deepwater fishes live much longer than previously estimated when relying on conventional age determination methods. In this study, we conducted bomb radiocarbon age validations of Warsaw Grouper and Snowy Grouper from the Gulf of Mexico. Radiocarbon age validation supported annual growth increment formation for all Warsaw Grouper size classes and medium-sized Snowy Grouper. Conversely, ages of larger, older Snowy Grouper were greatly underestimated due to difficulty in discriminating annuli. This bomb radiocarbon analysis validates a minimum 56-year longevity for both Warsaw Grouper and Snowy Grouper, increasing the currently published longevities of 41 and 54 years, respectively.