bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteome analysis of Mycoplasma fermentans cultured under aerobic and anaerobic conditions
Authors: Benedetti Francesca , Krishnan Selvi , Cocchi Fiorenza , Tettelin Hervé , Gallo Robert C. , Zella Davide , Curreli Sabrina 
Published: October 2019

AbstractBackground and aimsMycoplasmas are ubiquitous pathogens found not only in humans but also in animals, plants, insects and soil. Though they usually grow better in an aerobic environment, mycoplasmas are also facultative anaerobic microorganisms. Following infection, the transition of a microorganism from a normal environment into an anaerobic one (e.g. dead or dying tissue) may result in production of a higher number of bacterial toxins. The resolution of the bacterial proteome during the aerobic/anaerobic switch could thus allow the identification of potential pathogenic determinants and pathways.MethodsWe used two-dimensional gel electrophoresis (2-DE) coupled with matrix-assisted laser desorption/ionization time-of-flight/tandem mass spectroscopy (MALDI-TOF MS/MS) and subsequent mass spectrometric analysis to characterize the liposoluble and hydrosoluble protein fractions of a strain ofMycoplasma fermentansisolated in our lab (MFI), that was cultured under either aerobic or anaerobic conditions.ResultsWe identified the 27 most abundant proteins in the liposoluble fraction and the 30 most abundant proteins in the hydrosoluble fraction and determined their modulation under aerobic and anaerobic growth. By using Protein ANalysis TrougH Evolutionary Relationships (PANTHER) and the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) software analysis tools, we were able to identify, define and organize the function of each protein, as well as to determine the specific interactome.ConclusionsOur work provides the first proteome reference map ofMycoplasma fermentans obtained under aerobic and anaerobic growing conditions. These data may help to better understand the mechanisms of pathogenicity of this microorganism and define new diagnostic targets.
Gnrh1-Induced Responses Are Indirect in Female Medaka Fsh Cells, Generated Through Cellular Networks
Authors: Hodne Kjetil , Fontaine Romain , Ager-Wick Eirill , Weltzien Finn-Arne 
Published: October 2019

Abstract
Reproductive function in vertebrates is stimulated by GnRH that controls the synthesis and release of the two pituitary gonadotropins, FSH and LH. FSH and LH, which regulate different stages of gonadal development, are produced by two different cell types in the fish pituitary. This is in contrast to the situation in mammals and birds, and it enables investigation of their differential regulation. In the present study, we used fluorescence in situ hybridization to show that Lh cells in adult female medaka express Gnrh receptors, whereas Fsh cells do not. This result was confirmed by patch-clamp recordings and by cytosolic Ca2+ measurements on dispersed pituitary cells, where Lh cells, but not Fsh cells, responded to Gnrh1 by biphasic alteration in action-potential frequencies and cytosolic Ca2+ levels. In contrast, both Fsh and Lh cells are able to respond to Gnrh1 in brain-pituitary tissue slices both electrically and by elevating the cytosolic Ca2+ levels. Using Ca2+ uncaging in combination with patch-clamp recordings and cytosolic Ca2+ measurements, we show that Fsh and Lh cells form homotypic and heterotypic networks in the pituitary. Taken together, these results show that the effects of Gnrh1 on Fsh release in adult female medaka are indirect and probably mediated via Lh cells.
Individualizing Management of Infertility in Classic Congenital Adrenal Hyperplasia and Testicular Adrenal Rest Tumors
Authors: Jha Smita , El-Maouche Diala , Marko Jamie , Mallappa Ashwini , Veeraraghavan Padmasree , Merke Deborah P 
Published: October 2019

Abstract
Testicular adrenal rest tumors (TARTs) are a common cause of male infertility in patients with classic congenital adrenal hyperplasia (CAH). These tumors are located in the rete testis and can lead to impaired blood flow and functional impairment of seminiferous tubules. We describe restoration of fertility in a man with CAH and bilateral TARTs with use of lower-dose glucocorticoid therapy than previously described. A 28-year-old man with classic salt-wasting CAH presented with impaired fertility. Biochemical evaluation showed poor CAH control despite reported compliance with prednisone 5 mg every morning and fludrocortisone 50 μg twice daily. Semen analysis showed azoospermia. Testicular ultrasonography showed TARTs occupying 16% of total testicular volume. After 5 months of dexamethasone 250 μg at bedtime, total TART volume decreased 90%, biochemical control improved, and semen analysis showed a sperm count of 132 × 106 million per milliliter. The patient’s wife was confirmed to be pregnant 9 months after the initial visit and delivered a healthy full-term baby girl. The patient’s glucocorticoid therapy was changed to prednisone 3 mg twice daily, and 2 years later he continues to show adequate CAH control, stable TART volume, and normal semen analysis, and his wife is pregnant again. Management of CAH in men with TARTs needs to be individualized, and high-dose dexamethasone may not be indicated. The use of a long-acting glucocorticoid at typical recommended dosages can decrease TART size and reverse male infertility. Prednisone given once daily does not adequately control the ACTH-driven complications of CAH.
Endurance exercise resistance to lipotoxic cardiomyopathy is associated with cardiac NAD+/dSIR2/PGC-1αpathway activation in oldDrosophila
Authors: Wen Deng-Tai , Zheng Lan , Li Jin-xiu , Cheng Dan , Liu Yang , Lu Kai , Hou Wen-qi 
Published: October 2019

ABSTRACTLipotoxic cardiomyopathy is caused by excessive lipid accumulation in myocardial cells and it is a form of cardiac dysfunction. Cardiac PGC-1α overexpression prevents lipotoxic cardiomyopathy induced by a high-fat diet (HFD). The level of NAD+ and Sir2 expression upregulate the transcriptional activity of PGC-1α. Exercise improves cardiac NAD+ level and PGC-1α activity. However, the relationship between exercise, NAD+/dSIR2/PGC-1α pathway and lipotoxic cardiomyopathy remains unknown. In this study, flies were fed a HFD and exercised. The heart dSir2 gene was specifically expressed or knocked down by UAS/hand-Gal4 system. The results showed that either a HFD or dSir2 knockdown remarkably increased cardiac TG level and dFAS expression, reduced heart fractional shortening and diastolic diameter, increased arrhythmia index, and decreased heart NAD+ level, dSIR2 protein, dSir2 and PGC-1α expression levels. Contrarily, either exercise or dSir2 overexpression remarkably reduced heart TG level, dFAS expression and arrhythmia index, and notably increased heart fractional shortening, diastolic diameter, NAD+ level, dSIR2 level, and heart dSir2 and PGC-1α expression. Therefore, we declared that exercise training could improve lipotoxic cardiomyopathy induced by a HFD or cardiac dSir2 knockdown in old Drosophila. The NAD+/dSIR2/PGC-1α pathway activation was an important molecular mechanism of exercise resistance against lipotoxic cardiomyopathy.
A Sofística no Discurso Filosófico e Educacional de Michel de Montaigne
Authors: Carniel Flávia Rocha , Cunha Marcus Vinicius da 
Published: October 2019

O objetivo deste trabalho é examinar a produção intelectual do filósofo renascentista Michel de Montaigne, relacionando dados de sua biografia e dos acontecimentos de sua época à sua mais destacada obra, Ensaios. Considera-se que as elaborações teóricas de um indivíduo, bem como as formas linguísticas por ele criadas para exprimi-las, decorrem de eventos do mundo físico – no que se incluem as suas derivações de ordem social e cultural –, e como tal devem ser investigadas. A origem dessa concepção metodológica é buscada na filosofia antiga, principalmente nos Sofistas, investigação que fornece os parâmetros para analisar o caso específico de Montaigne.
ПРОБЛЕМЫ СОДЕРЖАНИЯ ТЕРМИНА «БЕСПОМОЩНОЕ СОСТОЯНИЕ» В УК РФ
Authors: Tydykova Nadezhda 
Published: October 2019

Статья посвящена исследованию термина «беспомощное состояние», который используется при конструировании многих составов преступлений. Автор анализирует его понимание правоприменительной практикой при квалификации разных составов преступлений. Отмечается, что официальные разъяснения по толкованию этого понятия имеются только применительно к убийству и насильственным половым преступлениям. Обосновывается, что понимание рассматриваемого признака в этих составах принципиально разное. Для квалификации насильственных половых преступлений он имеет более широкое содержание, чем для целей квалификации убийств. Доказывается, что в правоприменительной практике по-разному решаются и иные вопросы квалификации разных составов при его наличии. Это влечет проблему определения содержания термина для других составов, где он также используется, но не разъясняется. Предпринимается попытка дать объяснение разному смысловому наполнению одного и того же термина в зависимости от его места в составах преступлений. Высказано негативное отношение к такому подходу. В качестве разрешения сложившейся проблемы предлагается оставить рассматриваемый термин в таком наименовании лишь в некоторых составах, а в остальных заменить на какой-то иной. Это позволит разные термины наполнить разным смысловым значением. Для единообразия толкования предлагается дать разъяснения в соответствующих по тематике постановлениях Пленума Верховного Суда РФ или в специальном постановлении, посвященном толкованию оценочных признаков. Рекомендуется рассмотреть вопрос о расширении этого понятия для целей квалификации убийств и других насильственных преступлений для обеспечения полноты квалификации и назначения справедливого наказания виновным.
Development of Neural Network Based Adaptive Change Detection Technique for Land Terrain Monitoring with Satellite and Drone Images
Authors: Agarwal Ankush , Kumar Sandeep , Singh Dharmendra 
Published: October 2019

Role of satellite images is increasing in day-to-day life for both civil as well as defence applications. One of the major defence application while troop’s movement is to know about the behaviour of the terrain in advance by which smooth transportation of the troops can be made possible. Therefore, it is important to identify the terrain in advance which is quite possible with the use of satellite images. However, to achieve accurate results, it is essential that the data used should be precise and quite reliable. To achieve this with a satellite image alone is a challenging task. Therefore, in this paper an attempt has been made to fuse the images obtained from drone and satellite, to achieve precise terrain information like bare land, dense vegetation and sparse vegetation. For this purpose, a test area nearby Roorkee, Uttarakhand, India has been selected, and drone and Sentinel-2 data have been taken for the same dates. A neural network based technique has been proposed to obtain precise terrain information from the Sentinel-2 image. A quantitative analysis was carried out to know the terrain information by using change detection. It is observed that the proposed technique has a good potential to identify precisely bare land, dense vegetation, and sparse vegetation which may be quite useful for defence as well as civilian application.
Cord blood S100B: reference ranges and interest for early identification of newborns with brain injury
Authors: Bouvier Damien , Giguère Yves , Pereira Bruno , Bernard Nathalie , Marc Isabelle , Sapin Vincent , Forest Jean-Claude 
Published: October 2019

AbstractBackgroundNeurological complications are common in the premature and full-term neonates admitted to the intensive care unit, but the diagnosis of these complications is often difficult to make. S100B protein, measured in cord blood, may represent a valuable tool to better identify patients at risk of brain injury.MethodsAs a first step, we established S100B cord blood serum reference intervals from 183 preterm and 200 full-term neonates. We then measured cord blood serum S100B to identify neurological complications in 272 neonates hospitalized at the neonatal intensive care unit (NICU). Diagnosis of brain injury relied on imaging examination.ResultsThe 95th percentiles of S100B concentration in cord blood were established as 1.21 μg/L for the 383 neonates, 0.96 μg/L for full-term neonates and 1.36 μg/L for premature neonates. Among the 272 neonates hospitalized at the NICU, 11 presented neurological complications. Using 1.27 μg/L as the optimal sensitivity/specificity threshold, S100B differentiate neonates with and without neurological complications with a sensitivity of 45.5% (95% confidence intervals [CI]: 16.7–76.6) and a specificity of 88.9% (95% CI: 84.4–92.4) (p = 0.006). In combination with arterial pH (<7.25), sensitivity increased to 90.9% (95% CI: 58.7–99.8), while specificity was 51.2% (95% CI: 44.8–57.7). The sensitivity is significantly (p = 0.03) increased in comparison to S100B alone. The specificity is significantly higher with S100B only than with pH + S100B (p < 0.001).ConclusionsCord blood S100B protein, in combination with arterial cord blood pH, has the potential to help clinicians to detect at birth neurological complications in neonates hospitalized in an NCIU.
Fully Dielectric Rod Antenna Arrays with Integrated Power Divider
Authors: Tesmer Henning , Reese Roland , Polat Ersin , Nickel Matthias , Jakoby Rolf , Holger Maune and 
Published: October 2019

Abstract
This paper presents an overview of fully dielectric antenna arrays with integrated dielectric power dividers developed at Technische Universität Darmstadt as an extension of previous work. The power dividers are based on the principle of multimode interference and offer one- and two-dimensional power division in a single step, which allows the realization of small and lightweight devices. In order to prove the concept, 1 × 4 and 4 × 4 fully dielectric antenna arrays with integrated power dividers milled from Rexolite are designed, realized and characterized, operating between 90 GHz and 105 GHz. To assess miniaturization and beamsteering capabilities, three 1 × 4 arrays composed of different materials, Rexolite, Preperm L300 and Preperm L440, are compared regarding gain, size, weight and element spacing. Depending on array size and material, gain is between 12.5 dBi and 22 dBi, accompanied with sidelobe levels below - 7.5. All demonstrators are realized by milling, but the designs show the potential to be 3D printed or injection molded for large scale manufacturing.
Academic Partnerships: Social Determinants of Health Addressed though Service Learning
Authors: Breen Henny , Robinson Melissa 
Published: October 2019

Abstract
Aim To evaluate the impact of service learning through academic partnerships Background Although there is an abundance of literature regarding service learning as a pedagogical strategy for teaching pre-licensure students, there is a gap in the literature in regarding Associate Degree nurses returning to school to earn a bachelor’s degree. Method A qualitative study which included student assignments and interviews, written feedback and focus groups with staff from community organizations was used to evaluate the Service-Learning Program. Results Five primary themes emerged from the data which included a deeper understanding of vulnerable populations, increased knowledge of challenges in access to care, improved leadership skills, improved awareness of community resources, and impact on nursing practice. Conclusion Community organizations recognized the expertise of the RN to BSN students and benefited from their work and at the same time, students recognized their expertise and leadership in ways they had not done before.
Investigating the Predictors of Intrusive Visual Imagery in Elite Athletes
Authors: Bierton James , Gorman Adam , Lloyd Michael , Gorman Alexandra , Parker John K , Lovell Geoff p 
Published: October 2019

Abstract
The aims of this research were to determine if metacognitive beliefs predicted Intrusive Visual Imagery (IVI) in elite athletes, and if this was consistent across performance contexts. To address these aims, 110 elite cricket and AFL players completed the 30-item metacognitions questionnaire and intrusive visual imagery questionnaire before a training session and competitive match. Regression analyses indicated that the Negative Beliefs about the Uncontrollability of Thoughts and Their Danger metacognition and Need to Control Thoughts metacognition predicted IVI in both contexts. Findings were interpreted within the Self-Regulatory Executive Function model. It was suggested that extra attentional control is exerted to prevent the conscious experience of a negative belief, which prompts an image related to the belief being experienced, which is perceived as intrusive. Results also suggested that athletes are less likely to experience IVI before competing, possibly due to greater monitoring of thoughts. Implications for these findings are discussed.
A redetermination of the crystal structure of catena-poly[(bis(O,O′-isopropyl dithiophosphato-κ2
S,S′)-(μ2-1,2-bis(3-pyridylmethylene)hydrazine-κ2
N,N′)cadmium(II)], {C24H38CdN4O4P2S4}n
Authors: Tan Yee Seng , Tiekink Edward R.T. 
Published: October 2019

Abstract
C24H38CdN4O4P2S4, monoclinic, P21/n (no. 14), a = 12.2264(1) Å, b = 10.8805(1) Å, c = 12.9590(1) Å, β = 108.172(1)°, V = 1637.95(3) Å3, Z = 2, R
gt(F) = 0.0183, wR
ref(F
2) = 0.0468, T = 100(2) K.
Magnetic Pt single and double core-shell structures for the catalytic selective hydrogenation of cinnmaladehyde
Authors: Dinamarca Robinson B. , Espinoza-González Rodrigo , Campos Cristian H. , Pecchi Gina 
Published: October 2019

Abstract
This study reports the catalytic preparation, characterization, and evaluation of nanoscale core-shell structures with a γ-Fe2O3 core covered by a SiO2 monoshell or by a SiO2@TiO2 multishell as a support for Pt nanoparticles (NPs) to synthesize active and operationally stable catalysts for selective liquid-phase cinnamaldehyde hydrogenation. The structures were designed with a magnetic core so they could be easily recovered from the catalytic bed by simple magnetization and with a SiO2 monoshell or a SiO2@TiO2 multishell to protect the magnetic core. At the same time, this study details the effect of the shell on the catalytic performance. Moreover, the effect of particle size on the selective production of cinnamyl alcohol was studied by preparing two families of catalysts with metal loadings of 1 wt% and 5 wt% Pt with respect to the core-shell. The particle size effect enabled the Fe2O3@SiO2-5%Pt system, with an average particle size of 5.6 nm, to reach 100 % conversion of cinnamaldehyde at 300 min of reaction, producing cinnamyl alcohol with 90 % selectivity; this result differed greatly from that of the Fe2O3@SiO2-1%Pt (dPt = 3.5 nm) system, which reached a maximum conversion at 600 min with 49 % selectivity for the product of interest. However, the Fe2O3@SiO2@TiO2-x%Pt systems showed lower levels of conversion and selectivity compared to those of the Fe2O3@SiO2-x%Pt catalysts, which is attributed to the fact that average metal particle sizes below 5.0 nm were obtained in both cases. After reduction in H2 at 773 K, the Fe2O3@SiO2@TiO2-1%Pt catalyst showed deactivation, reaching 10 % conversion at 600 min of reaction and 60 % selectivity for the product of interest. However, the reduced Fe2O3@SiO2@TiO2-5%Pt system showed 98 % conversion with 95 % selectivity for cinnamyl alcohol at 24 h of operation; the increase in selectivity is attributed to the combined effects of the increase in average particle size (~7.5 nm) and the presence of strong metal-support interaction – SMSI – effects after reduction. Finally, the most selective systems were tested for operational stability, where the Fe2O3@SiO2@-5%Pt catalyst could be reused in three consecutive operating cycles while maintaining its activity and selectivity for cinnamyl alcohol – unlike the Fe2O3@SiO2@TiO2-5%Pt reduced system, which was deactivated after the third reaction cycle due to active phase leaching.
The Coase Theorem, the Nonempty Core, and the Legal Neutrality Principle
Authors: Crettez Bertrand 
Published: October 2019

AbstractThe Coase theorem states that where there are externalities and no transaction costs resource allocation is Pareto-optimal and independent of the stakeholders’ legal position. This result has been challenged many times. In the cooperative game approach to resource allocation, the refutation is made by constructing a three-person game which has an empty core under one set of liability rules—which implies that optimal allocations are coalitionally unstable–and a nonempty core under another set. In this example, however, the probability that the core is non-empty is rather high (5/6). Yet, even if coalitionally stable Pareto-optimal arrangements are likely, to establish the plain validity of the Coase theorem it must be shown that the legal neutrality statement also holds. We show that for the three-person cooperative game example mentioned above, the probability that the two assertions of the Coase theorem hold can be as low as 3/8.
Existence, uniqueness and stability of impulsive stochastic neutral functional differential equations driven by Rosenblatt process with varying-time delays
Authors: Lakhel El Hassan , Tlidi Abdelmonaim 
Published: October 2019

AbstractHermite processes are self-similar processes with stationary increments; the Hermite process of order 1 is fractional Brownian motion (fBm) and the Hermite process of order 2 is the Rosenblatt process. In this paper we consider a class of impulsive neutral stochastic functional differential equations with variable delays driven by Rosenblatt process with index{H\in(\frac{1}{2},1)}, which is a special case of a self-similar process with long-range dependence. More precisely, we prove an existence and uniqueness result, and we establish some conditions, ensuring the exponential decay to zero in mean square for the mild solution by means of the Banach fixed point theory. Finally, an illustrative example is given to demonstrate the effectiveness of the obtained result.