bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subjective well‐being and valuation of future health states: Discrepancies between anticipated and experienced life satisfaction
Authors: Walasek Lukasz , Brown Gordon D. A. , Ovens Gordon D. 
Published: September 2019

AbstractOne way of informing health policy decisions is to ask people about the impact that different health states would have on their future subjective well‐being. The present research explored the relation between anticipated and experienced changes in health‐related subjective well‐being, and examined whether affective forecasting errors could be reduced by psychological distancing manipulations. Using survey methodology, we tested whether people can accurately estimate the impact of different possible health states on their subjective well‐being. We also manipulated psychological distance: Forecasts were made about present self, future self, or others. Based on construal level theory and past work on affective forecasting errors, our prediction was that increasing psychological distance may reduce the mismatch between anticipated and experienced impact of health states on subjective well‐being. We found that the impact of ill health on subjective well‐being was greatly overpredicted and that this overprediction was not eliminated when participants were asked to make predictions about themselves in the future or about other people. Consistent with past work, we found that our participants correctly expected that their subjective well‐being would deteriorate more if they experienced the highest levels of mental illness as compared to the highest intensities of pain or most severe limitations to physical functioning.
Reconstructing the geographic and climatic origins of long‐distance bird migrations
Authors: Dufour Paul , Descamps Sébastien , Chantepie Stéphane , Renaud Julien , Guéguen Maya , Schiffers Katja , Thuiller Wilfried , Lavergne Sébastien 
Published: September 2019

AbstractAimSeasonal bird migration is one of the most fascinating global ecological phenomena. Yet, the biogeographic scenarios and climatic drivers that led single species or entire lineages to evolve seasonal migration between disjunct breeding and wintering ranges remain unclear. Based on distribution and phylogenetic data for all birds worldwide, we explored the biogeographic and climatic context of the evolutionary emergence of seasonal geographic migration in birds.LocationGlobal.TaxonThe Aves class (9,819 species).MethodsWe used the worldwide phylogeny of all birds, with a new backbone tree, to test the link between birds’ migration distance (short, variable, long) and strategy (resident, mixed, strict migrant) with four different metrics depicting species’ thermal niches in their breeding and wintering ranges. We also performed ancestral state reconstructions for the main migratory orders to reconstruct past events of appearance and loss of migration behaviour, and past biogeographic scenarios that led to the emergence of seasonal geographic migration.ResultsMigratory species generally experience warmer climates in their wintering range compared to their breeding one, although notable exceptions exist. This thermal niche change due to migration was found to be much larger for species travelling large distances. We also found that geographic migration emerged at different time periods through varied biogeographic paths (i.e. both from temperate and tropical ancestors) and that migration behaviour was likely ancestral to Passeriformes, with several subsequent episodes of loss of migration behaviour.Main conclusionsWe report an evolutionary correlation between long‐distance migration and the tendency of birds to seek warmer climates during their non‐breeding period, compared to short‐distance migrants. Migration behaviour was likely ancestral to Passeriformes, and migratory lineages in general seem to have often adapted to novel ecological opportunities by returning to a resident state. Our results provide the first large‐scale study of biogeographic and climatic origins of bird migration worldwide.
Schistosoma japonicum peptide SJMHE1 suppresses airway inflammation of allergic asthma in mice
Authors: Zhang Wenzhe , Li Li , Zheng Yu , Xue Fei , Yu Mengzhu , Ma Yongbin , Dong Liyang , Shan Zirui , Feng Dingqi , Wang Ting , Wang Xuefeng 
Published: September 2019

AbstractHelminths and their products can shape immune responses by modulating immune cells, which are dysfunctional in inflammatory diseases such as asthma. We previously identified SJMHE1, a small molecule peptide from the HSP60 protein of Schistosoma japonicum. SJMHE1 can inhibit delayed‐type hypersensitivity and collagen‐induced arthritis in mice. In the present study, we evaluated this peptide's potential intervention effect and mechanism on ovalbumin‐induced asthma in mice. SJMHE1 treatment suppressed airway inflammation in allergic mice, decreased the infiltrating inflammatory cells in the lungs and bronchoalveolar lavage fluid, modulated the production of pro‐inflammatory and anti‐inflammatory cytokines in the splenocytes and lungs of allergic mice, reduced the percentage of Th2 cells and increased the proportion of Th1 and regulatory T cells (Tregs). At the same time, Foxp3 and T‐bet expression increased, and GATA3 and RORγt decreased in the lungs of allergic mice. We proved that SJMHE1 can interrupt the development of asthma by diminishing airway inflammation in mice. The down‐regulation of Th2 response and the up‐regulation of Th1 and Tregs response may contribute to the protection induced by SJMHE1 in allergic mice. SJMHE1 can serve as a novel therapy for asthma and other allergic or inflammatory diseases.
Integrating Multiple Sources of Validity Evidence for an Assessment‐Based Cognitive Model
Authors: Langenfeld Thomas , Thomas Jay , Zhu Rongchun , Morris Carrie A. 
Published: September 2019

AbstractAn assessment of graphic literacy was developed by articulating and subsequently validating a skills‐based cognitive model intended to substantiate the plausibility of score interpretations. Model validation involved use of multiple sources of evidence derived from large‐scale field testing and cognitive labs studies. Data from large‐scale field testing were evaluated using traditional psychometric methods. The psychometric analyses were augmented using eye tracking technology to perform gaze pattern and pupillometry analyses to gain better understanding of problem‐solving strategies and cognitive load. Findings from the data sources were integrated to provide strong evidence supporting the model and score interpretations. Implications for using gaze pattern and pupillometry analyses to enhance learning and assessment are discussed.
Logistic Regression Procedure Using Penalized Maximum Likelihood Estimation for Differential Item Functioning
Authors: Lee Sunbok 
Published: September 2019

AbstractIn the logistic regression (LR) procedure for differential item functioning (DIF), the parameters of LR have often been estimated using maximum likelihood (ML) estimation. However, ML estimation suffers from the finite‐sample bias. Furthermore, ML estimation for LR can be substantially biased in the presence of rare event data. The bias of ML estimation due to small samples and rare event data can degrade the performance of the LR procedure, especially when testing the DIF of difficult items in small samples. Penalized ML (PML) estimation was originally developed to reduce the finite‐sample bias of conventional ML estimation and also was known to reduce the bias in the estimation of LR for the rare events data. The goal of this study is to compare the performances of the LR procedures based on the ML and PML estimation in terms of the statistical power and Type I error. In a simulation study, Swaminathan and Rogers's Wald test based on PML estimation (PSR) showed the highest statistical power in most of the simulation conditions, and LRT based on conventional PML estimation (PLRT) showed the most robust and stable Type I error. The discussion about the trade‐off between bias and variance is presented in the discussion section.
Disease burden of Crigler–Najjar syndrome: Systematic review and future perspectives
Authors: Dhawan Anil , Lawlor Michael W , Mazariegos George V , McKiernan Patrick , Squires James E , Strauss Kevin A , Gupta Digant , James Emma , Prasad Suyash 
Published: September 2019

AbstractBackground and AimCrigler–Najjar syndrome (CNS) results from biallelic mutations of UGT1A1 causing partial or total loss of uridine 5′‐diphosphate glucuronyltransferase activity leading to unconjugated hyperbilirubinemia and its attendant risk for irreversible neurological injury (kernicterus). CNS is exceedingly rare and has been only partially characterized through relatively small studies, each comprising between two and 57 patients.MethodsA systematic literature review was conducted to consolidate data on the patient, caregiver, and societal burden of CNS.ResultsTwenty‐eight articles on clinical aspects of CNS were identified, but no published data on its humanistic or economic burden were found. In patients with complete UGT1A1 deficiency (type 1 CNS [CNS‐I]), unconjugated bilirubin levels increase 3–6 mg/dL/day during the newborn period and reach neurologically dangerous levels between 5 and 14 days of age. Phototherapy is the mainstay of treatment but poses significant challenges to patients and their families. Despite consistent phototherapy, patients with CNS‐I have worsening hyperbilirubinemia with advancing age. Liver transplantation is the only definitive therapy for CNS‐I and is increasingly associated with excellent long‐term survival but also incurs high costs, medical and surgical morbidities, and risks of immunosuppression.ConclusionsCrigler–Najjar syndrome is associated with a substantial burden, even with existing standards of care. The development of novel disease‐modifying therapies has the potential to reduce disease burden and improve the lives of CNS patients and their families.
Resilience in Clinical Care: Getting a Grip on the Recovery Potential of Older Adults
Authors: Gijzel Sanne M. W. , Whitson Heather E. , van de Leemput Ingrid A. , Scheffer Marten , van Asselt Dieneke , Rector Jerrald L. , Olde Rikkert Marcel G. M. , Melis René J. F. 
Published: September 2019

BackgroundGeriatricians are often confronted with unexpected health outcomes in older adults with complex multimorbidity. Aging researchers have recently called for a focus on physical resilience as a new approach to explaining such outcomes. Physical resilience, defined as the ability to resist functional decline or recover health following a stressor, is an emerging construct.MethodsBased on an outline of the state‐of‐the‐art in research on the measurement of physical resilience, this article describes what tests to predict resilience can already be used in clinical practice and which innovations are to be expected soon.ResultsAn older adult's recovery potential is currently predicted by static tests of physiological reserves. Although geriatric medicine typically adopts a multidisciplinary view of the patient and implicitly performs resilience management to a certain extent, clinical management of older adults can benefit from explicitly applying the dynamical concept of resilience. Two crucial leads for advancing our capacity to measure and manage the resilience of individual patients are advocated: first, performing multiple repeated measurements around a stressor can provide insight about the patient's dynamic responses to stressors; and, second, linking psychological and physiological subsystems, as proposed by network studies on resilience, can provide insight into dynamic interactions involved in a resilient response.ConclusionA big challenge still lies ahead in translating the dynamical concept of resilience into clinical tools and guidelines. As a first step in bridging this gap, this article outlines what opportunities clinicians and researchers can already exploit to improve prediction, understanding, and management of resilience of older adults. J Am Geriatr Soc 67:2650–2657, 2019
A comparative study on auditory and hyoid bones of Jurassic euharamiyidans and contrasting evidence for mammalian middle ear evolution
Authors: Meng Jin , Mao Fangyuan , Han Gang , Zheng Xiao‐Ting , Wang Xiao‐Li , Wang Yuanqing 
Published: September 2019

AbstractThe holotypes of euharamiyidan Arboroharamiya allinhopsoni and Arboroharamiya jenkinsi preserve the auditory and hyoid bones, respectively. With additional structures revealed by micro‐computerized tomography (CT) and X‐ray micro‐computed laminography (CL), we provide a detailed description of these minuscule bones. The stapes in the two species of Arboroharamiya are similar in having a strong process for insertion of the stapedius muscle. The incus is similar in having an almond‐shaped body and a slim short process, in addition to a robust stapedial process with a short lenticular process preserved in A. allinhopsoni. The plate‐like ectotympanic in the two species of Arboroharamiya is similar and comparable to that of Qishou jizantang. The surangular in the two species has a fan‐shaped body and a needle‐shaped anterior process. The malleus, ectotympanic, and surangular are fully detached from the dentary and should have functioned exclusively for hearing. All the auditory bones of Arboroharamiya display unique features unknown in other mammaliaforms. Moreover, hyoid elements are found in the two species of Arboroharamiya and co‐exist with the five auditory bones in the holotype of A. allinhopsoni. The element interpreted as the stylohyal is similar to the bone identified as the ectotympanic in Vilevolodon. We reconstruct the auditory apparatus of Arboroharamiya and compare it with that of Vilevolodon as well as those in extant mammals and basal mammaliaforms. The comparison shows diverse morphological patterns of the auditory region in mammaliaforms. In particular, those of Vilevolodon and Arboroharamiya differ significantly: the former has a mandibular middle ear, whereas the latter possesses a definitive mammalian middle ear. It is puzzling that the two sympatric and dentally similar taxa have such different auditory apparatuses. In light of the available evidence, we argue that the mandibular middle ear reconstructed in Vilevolodon encounters many problems, and the so‐called ectotympanic in Vilevolodon may be interpreted as a stylohyal; thus, the dilemma can be resolved.
Novel solute carrier family 26, member 3 mutation in a prenatal recurrent case with congenital chloride diarrhea
Authors: Wu Siqi , Han Jin , Zhang Yongling , Ye Zhichao , Lu Ping , Tian Kege 
Published: September 2019

AbstractCongenital chloride diarrhea (CCD) is an autosomal recessive hereditary disease manifested by persistent, watery, profuse diarrhea with high chloride concentration (>90 mmol/L). Postnatally, neonates suffer from hypochloremia, hyponatremia, hypokalemia, metabolic alkalosis, dehydration, developmental retardation, or even death. Prenatal diagnosis is of great importance for the prognosis of CCD. We report a prenatal recurrent case of CCD. Prenatal ultrasound revealed fetal diffuse intestinal dilation with the typical honeycomb sign and polyhydramnios with high amniotic fluid index. The whole exome capture and massively‐parallel DNA sequencing showed an abnormal mutation of Solute Carrier Family 26, Member 3 (SLC26A3), c.1039G>A (p.Ala347Thr), and the mutation sites were verified by sanger sequencing. When prenatal ultrasound shows polyhydramnios and diffuse intestinal dilation, CCD should be suspected. Molecular genetic testing can be helpful for the diagnosis.
Effects of Lactobacillus plantarum on the intestinal morphology, intestinal barrier function and microbiota composition of suckling piglets
Authors: Wang Qi , Sun Qian , Qi Renli , Wang Jing , Qiu Xiaoyu , Liu Zuohua , Huang Jinxiu 
Published: September 2019

AbstractThis study investigated the effect of Lactobacillus plantarum strain 299v on gut health in suckling piglets. Sixty newborn piglets were assigned to control and probiotic treatments, with three litters per treatment (ten piglets/litter). From days 1 to 20 of life, piglets were orally administered a placebo of 0.1% peptone or 1.0 × 1010 CFU L. plantarum 299v daily. Six piglets per treatment were sacrificed on day 20, and intestinal tissues (including duodenum, jejunum, ileum and colon) and the intestinal contents from colon segments were collected. The results demonstrated that piglets treated with L. plantarum 299v had a lower diarrhoea incidence than the controls. L. plantarum 299v administration significantly increased the ratio of the villus height to the crypt depth in the jejunum and ileum, as well as the mRNA expression of jejunal occludin and ileal zonula occludens 1 (ZO‐1). The L. plantarum treatment also increased the mRNA abundance of porcine β‐defensin 2 (pBD2) and pBD3 in the jejunum and ileum and of toll‐like receptors (TLRs), such as TLR2, TLR4, TLR6 and TLR9 in the ileum, and significantly upregulated the mRNA abundances of ileal pBD1 and colonic TLR4. Additionally, the L. plantarum 299v treatment significantly changed the structure of the colonic microbiota, as evidenced by the obvious increases in the relative abundances of the phyla Firmicutes and Actinobacteria and of the genus Lactobacillus. Our findings indicate that L. plantarum 299v facilitates the gut health of suckling piglets, probably by improving the intestinal morphology and intestinal barrier function and by modifying the structure of the gut microbiota.
Effects of glucagon‐like peptides 1 and 2 and epidermal growth factor on the epithelial barrier of the rumen of adult sheep
Authors: Greco Gabriele , Amasheh Salah , Shen Zanming , Lu Zhongyan , Aschenbach Jörg R. 
Published: September 2019

AbstractEpidermal growth factor (EGF) and glucagon‐like peptides (GLP) modulate the tight junctions (TJ) of the intestinal epithelial barrier (EB) of monogastric animals. This work tried to elucidate whether GLP‐1, GLP‐2 and EGF can affect the EB of the rumen. Ovine ruminal epithelia were incubated in Ussing chambers for 7 hr with 25 or 250 nM of either GLP‐1 or GLP‐2 on the serosal side, with 2.5 nM of EGF on the serosal side or with 0.25 or 2.5 nM EGF on the mucosal side. No treatment affected tissue conductance. Short‐circuit current (Isc) was affected by time and treatment and their interactions. Only 250 nM of either GLP‐1 or GLP‐2 decreased Isc in certain periods compared with 25 nM GLP‐1 or 0.25 nM mucosally applied EGF; however, not when compared to control epithelia. Fluorescein flux rates (Jfluor) of ruminal epithelia were affected by treatment, time and time × treatment interaction. The time × treatment interaction was based on an increase in Jfluor between the first and last hour in epithelia incubated with 25 nM GLP‐1 or GLP‐2 and in epithelia incubated with EGF. After 7 hr incubation, claudin‐7 mRNA expression was downregulated in all treatments. Claudin‐1 mRNA was upregulated after incubation with 2.5 nM EGF on the serosal side, claudin‐4 mRNA was downregulated by 2.5 nM EGF on the mucosal side, and occludin mRNA was increased after incubation with 250 nM GLP‐2. The protein abundance of all tested TJ proteins was not influenced by treatment. We conclude that GLP‐1, GLP‐2, and EGF have no obvious acute effects on the EB of ruminal epithelia under simulated physiological conditions ex vivo. However, by decreasing the mRNA expression of claudin‐7 and partly affecting other TJ proteins, they may modulate EB in the longer term or under certain conditions.
Impacts of phenological variability in a predatory larval salamander on pond food webs
Authors: Anderson T. L. , Stemp K. M. , Ousterhout B. H. , Burton D. , Davenport J. M. 
Published: September 2019

AbstractPhenological shifts are expected to affect species interactions, in part by influencing which size classes, life stages or species occur simultaneously in a community. Yet, changes in phenology beyond shifts to the first, mean or median date of an ontogenetic event are underexplored in their importance to community dynamics. Using outdoor mesocosms, we experimentally mimicked increasing variability in breeding phenology of a top predatory salamander in pond food webs (Ambystoma annulatum) to assess its impacts on its own demographic traits and survival. We also tested whether variability in predator breeding would cascade to impact survival and diversity of lower trophic levels (intermediate salamander predators, anuran tadpoles, zooplankton and periphyton). We found that only variability in body size at metamorphosis of A. annulatum was impacted by phenological manipulations, with size variability being greater at higher levels of phenological variability. Because size at metamorphosis is often correlated with adult fitness, covarying variability in body size and phenology may lead to altered population dynamics. We also found that the density and size of A. annulatum were better predictors of overall survival and diversity of amphibian prey compared to phenological variability. We speculate that overwintering mortality of A. annulatum due to pond freezing modulated the impacts of phenological variability, such that changes in demographic traits and cascading effects throughout the food web were mollified.
A European ECMM‐ESCMID survey on goals and practices for mycobiota characterisation using next‐generation sequencing
Authors: Gangneux Jean‐Pierre , Guegan Hélène , Vandenborght Louise‐Eva , Buffet‐Bataillon Sylvie , Enaud Raphael , Delhaes Laurence 
Published: September 2019

SummaryAlthough substantial efforts have been made to investigate about the composition of the microbiota, fungi that constitute the mycobiota play a pivotal role in maintaining microbial communities and physiological processes in the body. Here, we conducted an international survey focusing on laboratory's current procedures regarding their goals and practices of mycobiota characterisation using NGS. A questionnaire was proposed to laboratories affiliated to working groups from ECMM (NGS study group) and ESCMID (ESGHAMI and EFISG study groups). Twenty‐six questionnaires from 18 countries were received. The use of NGS to characterise the mycobiota was not in routine for most of the laboratories (N = 23, 82%), and the main reason of using NGS was primary to understand the pathophysiology of a dysbiosis (N = 20), to contribute to a diagnosis (N = 16) or to implement a therapeutic strategy (N = 12). Other reported reasons were to evaluate the exposome (environmental studies) (N = 10) or to investigate epidemics (N = 8). Sputum is the main sample studied, and cystic fibrosis represents a major disease studied via the analysis of pulmonary microbiota. No consensus has emerged for the choice of the targets with 18S, ITS1 and ITS2 used alternatively among the laboratories. Other answers are detailed in the manuscript. We report a photography of mycobiota analysis that may become a major tool in the near future. We can draw some conclusions on the diversity of approaches within the answers of the 27 laboratories and underline the need for standardisation.