bluuebunny/crossref_metadata_2025_split huggingface dataset:
MicroRNA-150 down Regulation in Acute Myeloid Leukaemia Patients and Its Prognostic Implication
Authors: Abdelhalim Dalia Adel , Elgamal Basma M. , ElKafoury Mona R. , Hassan Naglaa M. , Hussein Marwa M. , Elhefnawi Mahmoud M. , Elfiky Asmaa M. , Hamdy Mohammad N. 
Published: November 2018

BACKGROUND: MicroRNAs (miRNAs) are small, non-coding RNAs that are important for post-transcriptional gene regulation in both healthy and morbid conditions. Numerous miRNAs promote tumorigenesis, while others have a tumour suppressive effects. Acute myeloid leukaemia (AML) is a heterogeneous group of genetically diverse hematopoietic malignancies with variable response to treatment.
AIM: Our study aimed to investigate the possible role of miR-150 in de novo adult AML and the impact of its level on survival, and we used in the silicon analysis to predict the main target genes involved in miR-150 mediated cancer pathway.
MATERIAL AND METHODS: We evaluated miR-150 expression profiling assay using TaqMan primer probes RT-PCR in the plasma of 50 adult AML patients, before the start of treatment and at day 28 of treatment, along with 20 normal adult control samples. miR-16 was used as an endogenous reference for standardisation. Follow-up of patients during treatment at day 28 of induction chemotherapy and after one year was done.
RESULTS: In this study, we found a significantly lower level of miR-150 in AML patients when compared to controls (p = 0.005) with 0.62 fold change than in healthy controls. Patients were divided into two groups: the low miR-150 group (miR-150 < 1) and the high miR-150 group (miR-150 > 1). A statistically significant difference was found between the two groups regarding initial total leukocytic count and initial PB blast count while for the TLC, HB and PLT count at follow up. No difference in the overall survival between the low and the high miR-150 groups could be demonstrated.
CONCLUSION: Our results suggest that miR-150 functions as a tumour suppressor and gatekeeper in inhibiting cell transformation and that its downregulation is required for leukemogenesis.
L’invention de l’indemnisation du chômage aux États-Unis
Authors: Bazzoli Laure , Kirat Thierry 
Published: November 2018

L’article porte sur l’émergence de la première loi d’indemnisation du chômage aux États-Unis en 1932 ( Wisconsin Unemployment Compensation Act ), et la contribution de J.R. Commons et de l’école institutionnaliste du Wisconsin. L’enracinement de cette loi dans la philosophie sociale pragmatiste explique une grande partie des dispositifs mis en place. Elle comprend aussi des propositions originales en vue de rendre le capitalisme raisonnable, de faire émerger une responsabilité sociale des entreprises et de renforcer les exigences démocratiques dans la vie économique. L’article souligne l’importance de cette première loi marquée du sceau de l’institutionnalisme et des débats qu’elle a suscités sur la trajectoire conduisant au système américain d’assurance-chômage institué en 1935.
Quelque part, ça laisse des traces. Mémoire et histoire des électriciens et gaziers de la région du Havre
Authors: Barzman John 
Published: November 2018

« Des électriciens ? Des gaziers ? Des métiers ? Qu'est-ce que cela peut bien être ? Aujourd'hui nous avons des 'commercial', des 'consultants', des 'intervenants extérieurs', des 'intérimaires'. Le client reçoit des services, à la hauteur, ni plus ni moins, de la qualité qu'il a payée. »

Entendra-t-on un jour ce discours ? Les auteurs de ce livre espèrent que non. En tout cas, ils nous racontent l'aventure peu commune d'un groupe d'hommes et de femmes de la région du Havre qui, pendant une cinquantaine d'années, ont réussi à concilier un travail digne, une technique d'avant-garde et le service de la collectivité. Soixante-dix personnes, du terrassier au cadre dirigeant, nous racontent leur savoir-faire, leur vie, la nationalisation, l'après-guerre, mai 1968, le charbon, le fioul, les réseaux et les raccordements, leurs craintes et leurs espoirs. Autour de trois sites principaux, le centre de production d'électricité nucléaire de Paluel, le centre de production thermique du Havre, le centre de distribution d'EDF-GDF, nous découvrons leur histoire, des chauffeurs de fours et des lampadaires à gaz aux ordinateurs.
Constituição da Tecnoarte: a emergência dos meios digitais e o diálogo com a produção do texto nos meios analógicos
Authors: Silva Rogério Barbosa da 
Published: November 2018

O presente texto discute questões acerca da videopoesia, da poesia digital, da poesia sonora, da poesia intermedia, da land-art, da Sky-art, da holopoesia, entre outras, tendo em mente os desafios da escrita inseridos em um mundo virtual onde os próprios conceitos de poesia e de escrita são expandidos. Para isso, pensou-se aqui numa redefinição do que é o literário quando se está no ambiente digital. Como objeto, foram escolhidas produções de Álvaro Andrade Garcia e de Wilton Azevedo.
Deslocando as relações de gênero: infâncias e candomblé, contribuições para a educação com crianças pequenas
Authors: Souza Ellen Gonzaga Lima , Araújo Patrício Carneiro 
Published: November 2018

O presente artigo tem como objetivo apresentar parte dos dados da tese de Souza (2016), intitulada Experiências de infâncias com produções de culturas no Ilê Axé Omo Oxé Ibá Latan, em diálogo com os estudos feministas de Louro (2008), hooks (2013) e Daves (2016) e a perspectiva das pesquisas descoloniais de Quijano (2005) e Santos (2010), que rompem com uma perspectiva eurocêntrica, binária e cartesiana das relações de gênero. Destacamos a perspectiva de mundo yorubá quanto à questão de gênero como uma conjunção quartenária de princípios, cuja sintaxe organiza as categorias “aborô”, correspondente ao princípio masculino; iyabá, ao feminino; “metá-metá”, o que circula simultaneamente pelos dois primeiros, e “laí ibalopô”, o que se coloca para fora e além de qualquer perspectiva sexual e de gênero, diferente, contudo, da categoria “assexuado”, de matriz ocidental. Entretanto, constatou-se que mesmo em um espaço que subverte a perspectiva colonizada das relações de gênero em sua cosmologia, as crianças apresentam práticas que travam relações binárias que associam o feminino a aspectos de subalternidade e reservam ao masculino aspectos de superioridade. Em função disso, esse discurso termina por legitimar as mesmas características historicamente atribuídas ao feminino (delicadeza, fragilidade, inferioridade, etc.), como se o masculino estivesse ligado à cultura e o feminino à natureza. Considerando as experiências de infâncias no candomblé, com inspirações na lógica exúlica, descrita por Souza(2016), e na Pedagogia Macunaímica de Faria (2002), apresentam-se algumas possibilidades para a construção de pedagogias descolonizadoras para a educação com crianças pequenas.
Avaliando as práticas extensionistas na Universidade Federal de Viçosa – Campus Rio Paranaíba: das diretrizes do FORPROEX às percepções de atores envolvidos
Authors: Silva Lara Luíza , Deboçã Leonardo Pinheiro 
Published: November 2018

A oferta de vagas na educação superior cresceu significativamente no Brasil, principalmente após os anos de 1990, contexto no qual as universidades públicas assumem papel relevante no tocante ao tripé ensino, pesquisa e extensão. O objetivo deste trabalho foi avaliar a percepção de docentes e de empresários sobre as atividades de extensão na Universidade Federal de Viçosa – Campus de Rio Paranaíba, em Minas Gerais, Brasil. A avaliação teve como parâmetros as diretrizes para ações de extensão universitária propostas pelo FORPROEX (Fórum de Pró-Reitores de Extensão das Universidades Públicas Brasileiras) pactuadas em 2012. A pesquisa teve caráter quantitativo e qualitativo, objetivando descrever o perfil dos respondentes (15 docentes e 20 empresários) e o significado da extensão para os mesmos, bem como, a conformidade das atividades de extensão com os objetivos do FORPROEX. A mensuração das diretrizes foi pautada em uma escala likert de 1 a 7 pontos. Quanto aos resultados, destaca-se que apenas para a diretriz Indissociabilidade Ensino-Pesquisa-Extensão ocorreram diferenças significativas das médias entre docentes e empresários. A diretriz Impacto e Transformação Social foi a de menor desempenho na avaliação dos empresários, enquanto a de maior desempenho foi a Indissociabilidade Ensino-Pesquisa-Extensão, também na avaliação dos empresários. Dentre as contribuições deste trabalho, destaca-se a possível utilização dos resultados para a avaliação de ações, políticas e diretrizes, relativas às atividades de extensão, praticadas pela Universidade, visando melhor alinhamento de interesses e expectativas entre Universidade e comunidade local.
Intención emprendedora en contexto universitario brasileño
Authors: Souza Roosiley dos Santos , Silveira Amelia 
Published: November 2018

El objetivo fue validar el Entrepreneurial Intention Questionnaire (EIQ[1]), como medida de la intención emprendedora en contexto universitario brasileño. El EIQ revisado por Liñán, Urbano y Guerrero (2011) toma como base la Teoría del Comportamiento Planeado (TCP), de Azjen (1991). La investigación consideró la Universidade Federal de Mato Grosso do Sul y la Universidade Federal da Grande Dourados, en el estado de Mato Grosso do Sul, Brasil. Cuantitativa y descriptiva, fue realizada con 505 alumnos de graduación de los cursos de Administración y de Ingeniería de Producción, en las dos universidades. El Modelaje de Ecuaciones Estructurales (MEE), con mínimos cuadrados parciales y modelo de caminos y el software SmartPLS 2.0 M3 dieron sustentación a los procedimientos estadísticos. Los constructos presentaron relaciones positivas y significantes explicando 13% de la varianza de la AP, 21,2% del CCP y 57,3% de la IE. La relación entre la AP y la IE demostró la mayor fuerza, denotando el papel consolidado de la relación teórica. Los resultados indican que el EIQ fue validado, con prueba de las hipótesis, pudiendo ser considerado como modelo de medida para la intención emprendedora en el contexto de universidades brasileñas. [1] Por su sigla en inglés y portugués.
Política de interiorização do ensino superior: taxa de sucesso na graduação na Universidade Federal do Paraná
Authors: Corrêa Ricardo Leitoles , Do Nascimento Décio Estevão 
Published: November 2018

Visando a democratização da educação superior no Brasil, foram implementadas diversas políticas públicas. Entre elas a expansão/interiorização do ensino superior público, impulsionada principalmente pelo Programa de Reestruturação e Expansão das Universidades Federais - REUNI. O propósito do programa era ampliar o acesso e permanência dos estudantes na educação superior. O objetivo desse artigo é avaliar a eficácia da interiorização do ensino superior no âmbito da Universidade Federal do Paraná após 2007 por meio da taxa de sucesso na graduação dos cursos e polos localizados fora da capital do estado. Esse indicador foi estabelecido para avaliação do programa REUNI e também se encontra no Plano Nacional da Educação. O estudo se configura como uma pesquisa descritiva, adotando uma abordagem quantitativa e se utiliza de indicador para análise dos dados. Para o cálculo da taxa de sucesso, foi utilizada a metodologia proposta pelo Tribunal de Contas da União. A partir dos resultados da pesquisa, pode-se inferir que o processo de interiorização da Universidade Federal do Paraná contribuiu para a redução da taxa de sucesso geral dos cursos de graduação, distanciando-se da meta prevista. Os três polos analisados apresentaram valores inferiores à média da UFPR, sendo que a menor média foi encontrada no campus de Matinhos.
Aerosol water parameterization: long-term evaluation and importance for climate studies
Authors: Metzger Swen , Abdelkader Mohamed , Steil Benedikt , Klingmüller Klaus 
Published: November 2018

Abstract. We scrutinize the importance of aerosol water for the aerosol optical depth
(AOD) calculations using a long-term evaluation of the EQuilibrium
Simplified Aerosol Model v4 for climate modeling. EQSAM4clim is
based on a single solute coefficient approach that efficiently parameterizes
hygroscopic growth, accounting for aerosol water uptake from the
deliquescence relative humidity up to supersaturation. EQSAM4clim extends the
single solute coefficient approach to treat water uptake of multicomponent
mixtures. The gas–aerosol partitioning and the mixed-solution water uptake
can be solved analytically, preventing the need for iterations, which is
computationally efficient. EQSAM4clim has been implemented in the global
chemistry climate model EMAC and compared to ISORROPIA II on climate
timescales. Our global modeling results show that (I) our EMAC results of the
AOD are comparable to modeling results that have been independently evaluated
for the period 2000–2010, (II) the results of various aerosol properties of
EQSAM4clim and ISORROPIA II are similar and in agreement with AERONET and
EMEP observations for the period 2000–2013, and (III) the underlying
assumptions on the aerosol water uptake limitations are important for derived
AOD calculations. Sensitivity studies of different levels of chemical aging
and associated water uptake show larger effects on AOD calculations for the
year 2005 compared to the differences associated with the application of the
two gas–liquid–solid partitioning schemes. Overall, our study demonstrates
the importance of aerosol water for climate studies.
Alteration of nitrous oxide emissions from floodplain soils by aggregate size, litter accumulation and plant–soil interactions
Authors: Ley Martin , Lehmann Moritz F. , Niklaus Pascal A. , Luster Jörg 
Published: November 2018

Abstract. Semi-terrestrial soils such as floodplain soils are
considered potential hot spots of nitrous oxide (N2O) emissions. Microhabitats
in the soil – such as within and outside of aggregates, in the detritusphere, and/or in
the rhizosphere – are considered to promote and preserve specific redox conditions. Yet
our understanding of the relative effects of such microhabitats and their interactions on
N2O production and consumption in soils is still incomplete. Therefore, we
assessed the effect of aggregate size, buried leaf litter, and plant–soil interactions
on the occurrence of enhanced N2O emissions under simulated flooding/drying
conditions in a mesocosm experiment. We used two model soils with equivalent structure
and texture, comprising macroaggregates (4000–250 µm) or microaggregates
(<250 µm) from a N-rich floodplain soil. These model soils were planted with
basket willow (Salix viminalis L.), mixed with leaf litter or left unamended.
After 48 h of flooding, a period of enhanced N2O emissions occurred in all
treatments. The unamended model soils with macroaggregates emitted significantly more
N2O during this period than those with microaggregates. Litter addition
modulated the temporal pattern of the N2O emission, leading to short-term peaks
of high N2O fluxes at the beginning of the period of enhanced N2O
emission. The presence of S. viminalis strongly suppressed the N2O
emission from the macroaggregate model soil, masking any aggregate-size effect.
Integration of the flux data with data on soil bulk density, moisture, redox potential
and soil solution composition suggest that macroaggregates provided more favourable
conditions for spatially coupled nitrification–denitrification, which are particularly
conducive to net N2O production. The local increase in
organic carbon in the detritusphere appears to first stimulate N2O emissions;
but ultimately, respiration of the surplus organic matter shifts the system towards redox
conditions where N2O reduction to N2 dominates. Similarly, the low
emission rates in the planted soils can be best explained by root exudation of
low-molecular-weight organic substances supporting complete denitrification in the anoxic
zones, but also by the inhibition of denitrification in the zone, where rhizosphere
aeration takes place. Together, our experiments highlight the importance of microhabitat
formation in regulating oxygen (O2) content and the completeness of
denitrification in soils during drying after saturation. Moreover, they will help to
better predict the conditions under which hot spots, and “hot
moments”, of enhanced
N2O emissions are most likely to occur in hydrologically dynamic soil systems
like floodplain soils.
A high-resolution air temperature data set for the Chinese Tian Shan in 1979–2016
Authors: Gao Lu , Wei Jianhui , Wang Lingxiao , Bernhardt Matthias , Schulz Karsten , Chen Xingwei 
Published: November 2018

Abstract. The Chinese Tian Shan (also known as the Chinese Tianshan Mountains, CTM) have a complex ecological
environmental system. They not only have a large number of desert oases but
also support many glaciers. The arid climate and the shortage of water
resources are the important factors restricting the area's socioeconomic
development. This study presents a unique high-resolution (1 km, 6-hourly)
air temperature data set for the Chinese Tian Shan
(41.1814–45.9945∘ N, 77.3484–96.9989∘ E) from 1979
to 2016 based on a robust elevation correction framework. The data set was
validated by 24 meteorological stations at a daily scale. Compared to
original ERA-Interim temperature, the Nash–Sutcliffe efficiency coefficient
increased from 0.90 to 0.94 for all test sites. Approximately 24 % of the
root-mean-square error was reduced from 3.75 to 2.85 ∘C. A skill
score based on the probability density function, which was used to validate
the reliability of the new data set for capturing the distributions,
improved from 0.86 to 0.91 for all test sites. The data set was able to
capture the warming trends compared to observations at annual and seasonal
scales, except for winter. We concluded that the new high-resolution data
set is generally reliable for climate change investigation over the Chinese
Tian Shan. However, the new data set is expected to be further
validated based on more observations. This data set will be helpful for
potential users to improve local climate monitoring, modeling, and
environmental studies in the Chinese Tian Shan. The data set
presented in this article is published in the Network Common Data Form
(NetCDF) at https://doi.org/10.1594/PANGAEA.887700. The data set includes 288 nc files
and one user guidance txt file.
Evaluation of The National Council for Accreditation of Teacher Education (NCATE) Al-Taif University and The Middle East as Model
Authors: Daradkah Amajid , Osimi Khaled Al , Hamadin Khaled M 
Published: November 2018

the faculties of education at the Universities of Taif and the Middle East in light of the standards National Council for the Accreditation of Teacher Education (NCATE) for the adoption of teacher preparation institutions from the viewpoint of faculty members. The samples were taken randomly, and the data source was from 93 (50%) of faculty members of the institution. The study results showed moderate application of the quality of the performance of the faculties of education at the Universities of Taif and the Middle East in light of the NCATE standards with a mean (2.91) and ranged averages between 2.69 to 3.13. This is done based on the qualities of performance such as professional development of faculty members; the diversity of learners and the sources of their learning; evaluation and correction; field education; and programs provided, respectively. There are statistically significant differences (≤ 0.05 ) between the average responses of the sample members of the two colleges of education at Taif and Middle East universities due to the variables (the university, and academic rank, years of experienced). Also, there were no significant differences related to gender differences. The study concluded that several recommendations, including: revision of the current teacher training in the faculties of education at the Universities of Taif and the Middle East commensurate with the standards. National Council for the Accreditation of Teacher Education (NCATE) works on selecting outstanding school field training program.
Etnografía musical en el Río Magdalena: el son de Berroche de la Subregión de Loba
Authors: Ciro Gómez Bernardo Alonso 
Published: November 2018

La Tambora es una manifestación de tradición oral celebrada por los habitantes de los municipios ubicados al sur de los departamentos de Bolívar, Cesar y Magdalena en Colombia. A través de una etnografía musical, se hicieron hallazgos a partir del son de berroche que podrían representar la necesidad de observarlas y estudiarlas desde otro locus de enunciación, permitiendo que las prácticas de investigación en artes reconozcan la importancia de la construcción conjunta en el desarrollo de los procesos de conocimiento y de transformación social. Indagar por el son de berroche comprendiendo las percepciones, sensaciones y sensibilidades de los detentores, y la forma en cómo sus prácticas musicales son subsumidas por constructos identitarios, por las dimensiones objetiva y subjetiva de la realidad social y como evidencia de constantes procesos de negociación, pone de manifiesto la necesidad de una construcción dialógica entre la investigación en artes y los discursos de disciplinas como la Etnomusicología y la Antropología de la Música.
DockerBIO: web application for efficient use of bioinformatics Docker images
Authors: Kwon ChangHyuk , Kim Jason , Ahn Jaegyoon 
Published: November 2018

Background and Objective
Docker is a light containerization program that shows almost the same performance as a local environment. Recently, many bioinformatics tools have been distributed as Docker images that include complex settings such as libraries, configurations, and data if needed, as well as the actual tools. Users can simply download and run them without making the effort to compile and configure them, and can obtain reproducible results. In spite of these advantages, several problems remain. First, there is a lack of clear standards for distribution of Docker images, and the Docker Hub often provides multiple images with the same objective but different uses. For these reasons, it can be difficult for users to learn how to select and use them. Second, Docker images are often not suitable as a component of a pipeline, because many of them include big data. Moreover, a group of users can have difficulties when sharing a pipeline composed of Docker images. Users of a group may modify scripts or use different versions of the data, which causes inconsistent results.

Methods and Results
To handle the problems described above, we developed a Java web application, DockerBIO, which provides reliable, verified, light-weight Docker images for various bioinformatics tools and for various kinds of reference data. With DockerBIO, users can easily build a pipeline with tools and data registered at DockerBIO, and if necessary, users can easily register new tools or data. Built pipelines are registered in DockerBIO, which provides an efficient running environment for the pipelines registered at DockerBIO. This enables user groups to run their pipelines without expending much effort to copy and modify them.