bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Adherence to Statins, Illness Perception, Treatment Satisfaction, and Quality of Life among Lebanese patients
Authors: Haddad Christine , Hallit Souheil , Salhab Mohammad , Hajj Aline , Sarkis Antoine , Ayoub Eliane Nasser , Jabbour Hicham , Khabbaz Lydia Rabbaa 
Published: April 2018

Objectives: The main objective of this study was to evaluate treatment adherence to statin and health-related quality of life (QOL) in Lebanese patients with dyslipidemia. Secondary objectives were to examine associations between treatment adherence, QOL, treatment satisfaction, and illness perception. Methods: This cross-sectional study, conducted in 20 community pharmacies from all districts of Lebanon between August 2016 and April 2017, enrolled 247 adult patients taking any statin. Results: The mean age of the participants was 52.63 ± 11.92 years (57.5% males); the mean duration of treatment with a statin was 59.72 months. A significant association was found between adherence and marital status ( P < .0001), educational level ( P = .001), cigarette smoking ( P < .0001), and alcohol drinking ( P < .0001). A negative but significant correlation was found between the adherence score and the duration of dyslipidemia ( r = −0.199). A significant but negative correlation was also found between the side effect score and age ( r = −0.137). The monthly salary, the marital status, the educational level, smoking cigarettes or waterpipes, and drinking alcohol were all associated with the Illness Perception Questionnaire scores ( P < 0.0001 for all variables). Secondary level of education (β = 13.43), smoking more than 3 waterpipes per week (β = 14.06), global satisfaction score (β = 0.32), convenience score (β = 0.29), and effectiveness score (β = 0.27) would significantly increase the adherence score. Smoking more than 15 cigarettes per day (β = −11.15) and a divorced status (β = −14.81) would however significantly decrease the adherence score. Significant associations were found between the illness perception score, the QOL domains, and the satisfaction domains ( P < .05 for all variables). Conclusion: This study showed that global satisfaction with treatment, convenience, and effectiveness are important factors that increase treatment adherence. Patient adherence results in patient satisfaction and improved QOL and is an important criterion for achieving desired therapeutic outcomes.
Polymorphisms in the TOX3/LOC643714 and risk of breast cancer in south China
Authors: Liao Jinling , Chen Yang , Zhu Jia , Wang Qiuyan , Mo Zengnan 
Published: April 2018

Objective: Breast cancer is the most widespread cancer in women, with a high mortality rate. This study aims to assess the association between single nucleotide polymorphisms (SNPs) of LOC643714 (rs12922061) and TOX3 (rs3803662) and breast cancer, as well as the clinical characteristics of tumors. Materials and methods: In total, 104 breast cancer patients and 118 healthy controls were recruited to our study. The genotyping was performed by the SNP scan method. General characteristics, the clinical characteristics of tumors and reproductive factors were included in the analysis. Statistical tests included the Student t-test, the Chi-square test (X2) or Fisher’s exact test, and unconditional logistic regression analysis. The receiver operating characteristic curves were used to evaluate the predictive role of rs12922061 in breast cancer. Results: The LOC643714 polymorphism was a risk factor for breast cancer under a dominant model (TT+TC vs. CC: OR 1.801; 95% CI 1.048, 3.095; statistical power=60%), recessive model (TT vs. TC + CC: OR 4.297; 95% CI 1.164, 15.867; statistical power=64%) and log-additive (TT vs. CC: OR 5.163; 95% CI 1.368, 19.485; statistical power= 73%). Furthermore, the rs12922061 polymorphism was associated with menopause status in patients ( P=0.005). No statistically significant association was found between the rs3803662 polymorphism and breast cancer in patients or healthy controls. Conclusions: Our study found that rs12922061 of LOC643714 was related to breast cancer risk. With a limited sample size and statistical power, further multi-center studies are needed to confirm the influence of the LOC643714 polymorphisms on breast cancer based on larger populations.
Association of proton pump inhibitors with the risk of hepatic encephalopathy during hospitalization for liver cirrhosis
Authors: Zhu Jia , Qi Xingshun , Yu Haonan , Yoshida Eric M , Mendez-Sanchez Nahum , Zhang Xintong , Wang Ran , Deng Han , Li Jing , Han Dan , Guo Xiaozhong 
Published: April 2018

BackgroundHepatic encephalopathy is associated with altered gut microbiota. Proton pump inhibitors increase the risk of small bowel bacterial overgrowth.ObjectivesThis was a case‐control study aimed at exploring the relationship of proton pump inhibitor use with the risk of hepatic encephalopathy during hospitalization in liver cirrhosis.MethodsCase and control groups were defined as cirrhotic patients who developed hepatic encephalopathy during hospitalization and those without hepatic encephalopathy at admission or during hospitalization, respectively. Age, gender, and Child‐Pugh score were matched between the groups. Odds ratios with 95% confidence intervals were calculated to express the association of proton pump inhibitors with the risk of hepatic encephalopathy. Four subgroup analyses were performed after excluding patients with acute upper gastrointestinal bleeding, infections, and in‐hospital death, and after matching model for end‐stage liver disease score.ResultsIn the overall analysis, 128 patients were included in each group of cases and controls. The proportion of proton pump inhibitor use was significantly higher in the case group than the control group (79.7% vs 43%, p < 0.001). Proton pump inhibitor use (odds ratio = 3.481, 95% confidence interval: 1.651–7.340, p = 0.001) was independently associated with the development of hepatic encephalopathy in the multivariate analysis. In the four subgroup analyses, proton pump inhibitor use remained independently associated with the risk of hepatic encephalopathy.ConclusionProton pump inhibitor use might increase the risk of hepatic encephalopathy during hospitalization.
Demographic Study of Hip Fractures in the Maltese Islands
Authors: Bugeja Mark , Aquilina Simon , Farrugia Charles , Esposito Ivan 
Published: April 2018

Introduction: Despite hip fractures being a great public health burden, only few studies have analyzed the relationship between hip fracture incidence and socioeconomic status. Many studies found an association; however, results are in part conflicting. Objective: To analyze the impact of regional-level socioeconomic status on the incidence of hip fractures in the Maltese Islands. Method: All individuals older than 50 years who presented to the acute care hospitals in Malta and Gozo with low-energy hip fractures between December 1, 2015, and November 30, 2016, were selected. Data on individual demographics, hip fracture type, surgical intervention, and hospital stay were collected. The percentage of hip fracture and socioeconomic status of each region in the Maltese Islands were calculated. These were then analyzed for any statistical association. Results: A moderate negative correlation ( r = −0.5987, N = 454, P < .05) was found between the socioeconomic status and the incidence of hip fracture in each region. There was 5.9% (n = 27) mortality rate posed by these hip fractures. The average duration of hospital stay was 14 days, with an average delay to surgical intervention of 2 days. Conclusion: Despite the Maltese Islands having a small population (429 344 people) and a free universal national health service, our results show that districts with low socioeconomic status had a higher incidence of hip fracture. Further studies using individual socioeconomic data and longer duration are required.
Hypomethylating agents in relapsed and refractory AML: outcomes and their predictors in a large international patient cohort
Authors: Stahl Maximilian , DeVeaux Michelle , Montesinos Pau , Itzykson Raphael , Ritchie Ellen K. , Sekeres Mikkael A. , Barnard John D. , Podoltsev Nikolai A. , Brunner Andrew M. , Komrokji Rami S. , Bhatt Vijaya R. , Al-Kali Aref , Cluzeau Thomas , Santini Valeria , Fathi Amir T. , Roboz Gail J. , Fenaux Pierre , Litzow Mark R. , Perreault Sarah , Kim Tae Kon , Prebet Thomas , Vey Norbert , Verma Vivek , Germing Ulrich , Bergua Juan Miguel , Serrano Josefina , Gore Steven D. , Zeidan Amer M. 
Published: April 2018

Key Points
In the largest study of HMAs in RR-AML to date, 16% of patients achieved CR/CRi and experienced a median OS of 21 months. Low proliferative disease (peripheral blood blasts <5%) was associated with improved response and OS.
Changing wage structure in India in the post-reform era: 1993–2011
Authors: Jacoby Hanan G. , Dasgupta Basab 
Published: April 2018

AbstractThis paper documents the changing structure of wages in India over the post-reform era, the roughly two-decade period since 1993. To investigate the factors underlying these changes, a supply-demand framework is applied at the level of the Indian state. While real wages have risen across India over the past two decades, the increase has been greater in rural areas and, especially, for unskilled workers. The analysis finds that, in rural areas, the changing wage structure has been driven largely by relative supply factors, such as increased overall education levels and falling female labor force participation. Relative wage changes between rural and urban areas have been driven largely by shifts in employment, notably into unskilled-intensive sectors like construction.JEL Classification:J21, J23, J24, J31
Pearls & Oy-sters: The critical role of histopathology in diagnosing cancer-associated necrotizing CNS vasculitis
Authors: Sheehan Joshua , Tate Jessica , Mott Ryan , Geer Carol , Wolfe Rachel , Strowd Roy E. , Guzik Amy 
Published: April 2018

ObjectiveTo highlight the importance of a broad differential and histopathologic confirmation in patients with newly diagnosed cancer with brain lesions atypical for CNS metastasis.MethodsWe report 2 cases of biopsy-proven CNS vasculitis in patients undergoing treatment for a newly diagnosed nonmetastatic cancer. Comprehensive medical record review was performed to identify the clinical presentation, representative neuroimaging, histopathologic features, and response to treatment.ResultsPatient 1 presented 1 month into induction therapy of malignant vaginal squamous cell carcinoma (stage 3, T2N1M0) with acute episodic left-sided hemiparesis due to seizure activity progressing to severe encephalopathy. Imaging revealed a right frontoparietal lesion while systemic workup was unrevealing. Biopsy demonstrated necrotizing vasculitis. Patient 2 presented 6 months after diagnosis of right breast invasive ductal carcinoma (stage IIa, T2N0M0, estrogen receptor–positive, progesterone receptor–positive, human epidermal growth factor receptor–2 positive) with subacute bifrontal headaches with associated phonophobia. Imaging showed hyperintense lesions involving the right temporoparietal region and systemic workup was unrevealing. Brain biopsy showed a necrotizing vasculitis. Patient 1 was treated with methyprednisolone and plasmapheresis and patient 2 was treated with prednisone. Both patients showed complete resolution of symptoms shortly after treatment and improvement on imaging.ConclusionsThese cases highlight the importance of comprehensive evaluation of new brain lesions in patients with nonmetastatic solid tumors. Characteristics of new brain lesions in patients with cancer that should raise suspicion of diagnoses other than brain metastasis include (1) primary malignancy without regional or distant metastasis, (2) imaging without discrete mass-like enhancement, and (3) cortically based location of lesions not at the gray–white matter junction.
The VLDL receptor regulates membrane progesterone receptor trafficking and non-genomic signaling
Authors: Nader Nancy , Dib Maya , Courjaret Raphael , Hodeify Rawad , Machaca Raya , Graumann Johannes , Machaca Khaled 
Published: April 2018

ABSTRACT
Progesterone mediates its physiological functions through activation of both transcription-coupled nuclear receptors and seven-pass-transmembrane progesterone receptors (mPRs), which transduce the rapid non-genomic actions of progesterone by coupling to various signaling modules. However, the immediate mechanisms of action downstream of mPRs remain in question. Herein, we use an untargeted quantitative proteomics approach to identify mPR interactors to better define progesterone non-genomic signaling. Surprisingly, we identify the very-low-density lipoprotein receptor (VLDLR) as an mPRβ (PAQR8) partner that is required for mPRβ plasma membrane localization. Knocking down VLDLR abolishes non-genomic progesterone signaling, which is rescued by overexpressing VLDLR. Mechanistically, we show that VLDLR is required for mPR trafficking from the endoplasmic reticulum to the Golgi. Taken together, our data define a novel function for the VLDLR as a trafficking chaperone required for the mPR subcellular localization and, as such, non-genomic progesterone-dependent signaling.
This article has an associated First Person interview with the first author of the paper.
New records of Ephemeroptera (Insecta) from Roraima State, Northern Brazil
Authors: Gama Neto Jaime de Liege , Passos Mahedy Araujo Bastos , Cruz Jenisson Araujo , Souza Nazareno Trajano de 
Published: April 2018

Abstract. The aim of this work is to present new records and distributional notes of Ephemeroptera species on Roraima states. Farrodes maculatus Domínguez, Molineri & Peters, 1996, Hermanellopsis incertans (Spieth, 1943) and Thraulodes marreroi Chacón, Segnini & Domínguez, 1999 are recorded for the first time in Brazil. Family Coryphoridae, Callibaetis cruentus Cruz, Salles & Hamada, 2014, Callibaetis gelidus Cruz, Salles & Hamada, 2014, Campylocia demoulini Gonçalves & Salles, 2017, Coryphorus aquilus Peters, 1981, Fittkaulus cururuensis Savage, 1986, Fittkaulus maculatus Savage & Peters, 1978, Miroculis fittkaui Savage & Peters, 1983, and Simothraulopsis sabalo Kluge, 2007 are recorded for the first time in Roraima. The number of known species of Ephemeroptera in Roraima, after our study, has increased from 64 to 75. Novos registros de Ephemeroptera (Insecta) do Estado de Roraima, norte do BrasilResumo. O objetivo deste trabalho é apresentar novos registros de espécies e notas sobre a distribuição geográfica de Ephemeroptera no Estado de Roraima. As espécies Farrodes maculatus Domínguez, Molineri & Peters, 1996, Hermanellopsis incertans (Spieth, 1943) e Thraulodes marreroi Chacón, Segnini & Domínguez, 1999 são registradas pela primeira vez no Brasil. A família Coryphoridae e as espécies Callibaetis cruentus Cruz, Salles & Hamada, 2014, Callibaetis gelidus Cruz, Salles & Hamada, 2014, Campylocia demoulini Gonçalves & Salles, 2017, Coryphorus aquilus Peters, 1981, Fittkaulus cururuensis Savage, 1986, Fittkaulus maculatus Savage & Peters, 1978, Miroculis fittkaui Savage & Peters, 1983 and Simothraulopsis sabalo Kluge, 2007 são registradas pela primeira vez no estado de Roraima. O número de espécies de Ephemeroptera com registros de ocorrência em Roraima é elevado de 64 a 75.
Uncertainty evaluation in clinical chemistry, immunoassay, hematology and coagulation analytes using only external quality assessment data
Authors: Qin Yanyan , Zhou Rui , Wang Wei , Yin Hongyi , Yang Yanmin , Yue Yuhong , Tong Qing , Liu Lu , Jin Yali , Shi Yankun , Zhang Shunli , Zhang Jianping , Zhang Rui , Zuo Chang , Jia Tingting , Wang Ning , Wang Qingtao 
Published: April 2018

Abstract

Background:
Measurement uncertainty (MU) is a parameter associated with the result of a measurement that characterizes its dispersion. We report results for estimating MU following the application of a top-down procedure using only proficiency test data to establish uncertainty levels for various analytes.

Methods:
Data were obtained from 142 laboratories participating in the Beijing Center for Clinical Laboratory (BCCL) proficiency testing/external quality assessment (PT/EQA) schemes. The 24-month study included six selected PT shipments to obtain estimates for 50th percentile (median) and 90th percentile MUs and to compare those estimates to usual analytic goals. The number of laboratory participants varied for each trial. The expanded uncertainty (U) was calculated using a cover factor of k=2 for a confidence interval of 95%. All reproducibility, method and laboratory biases came from the PT/EQA data.

Results:
The median U (k=2) ranged from 3.2% (plasma sodium, indirect ion selective electrode) to 32.8% (triglycerides, free glycerol blanking) for clinical chemistry analyte means from participants in the same method group. Immunoassay analyte median U results ranged from 11.3% (CA125 tumor marker, Roche) to 33.8% (prostate-specific antigen [PSA], Abbott). The range for median U was 3.5% (red blood cell [RBC], Abx) to 30.3% (fibrinogen [FBG], other) for hematology and coagulation analytes. The MUs for most analytes satisfied quality requirements.

Conclusions:
The use of PT/EQA data, when available, provides an effective means for estimating uncertainties associated with quantitative measurements. Thus, medical laboratories can calculate their own MUs. Proficiency testing organizers can provide participants with an additional MU estimate using only EQA data, which may be updated at the end of each survey.
Molecular arrangements in crystals of racemic and enantiopure forms of N-carbamoyl-2-phenylbutyramide and 2-phenylbutyramide: differences and similarities
Authors: Krivoshein Arcadius V. , Lindeman Sergey V. , Bentum Samuel , Averkiev Boris B. , Sena Victoria , Timofeeva Tatiana V. 
Published: April 2018

Abstract
As solid drugs may be regarded as “pharmaceutical materials”, molecular pharmaceutics of such drugs is expected to benefit from application of materials science concepts. In this paper, we used a structural chemistry approach to explain the dramatic difference in solubility between two structurally related antiepileptic drugs, N-carbamoyl-2-phenylbutyramide (NC2PBA) and 2-phenylbutyramide (2PBA). Since both of these compounds are chiral, we chromatographically separated the enantiomers and examined them along with the racemic forms. A combination of experimental (single-crystal X-ray diffraction, IR spectroscopy) and computational (crystal lattice energy calculations, Hirshfeld surface analysis) techniques was employed to determine the structural differences between these two compounds in the crystalline state. We found that while NC2PBA and 2PBA have similar molecular packing arrangements, the former compound is distinguished by a more extensive network of hydrogen bonds. Thus, the higher density, higher melting point, and lower solubility of crystalline NC2PBA compared to crystalline 2PBA may be largely explained by the differences in hydrogen bonding. We also found that for each of these compounds there are no major differences in molecular packing (and, correspondingly, in crystal lattice energies) between racemic and enantiopure forms.
How Much Does Movement and Location Encoding Impact Prefrontal Cortex Activity? An Algorithmic Decoding Approach in Freely Moving Rats
Authors: Lindsay Adrian J. , Caracheo Barak F. , Grewal Jamie J. S. , Leibovitz Daniel , Seamans Jeremy K. 
Published: April 2018

AbstractSpecialized brain structures encode spatial locations and movements, yet there is growing evidence that this information is also represented in the rodent medial prefrontal cortex (mPFC). Disambiguating such information from the encoding of other types of task-relevant information has proven challenging. To determine the extent to which movement and location information is relevant to mPFC neurons, tetrodes were used to record neuronal activity while limb positions, poses (i.e., recurring constellations of limb positions), velocity, and spatial locations were simultaneously recorded with two cameras every 200 ms as rats freely roamed in an experimental enclosure. Regression analyses using generalized linear models revealed that more than half of the individual mPFC neurons were significantly responsive to at least one of the factors, and many were responsive to more than one. On the other hand, each factor accounted for only a very small portion of the total spike count variance of any given neuron (<20% and typically <1%). Machine learning methods were used to analyze ensemble activity and revealed that ensembles were usually superior to the sum of the best neurons in encoding movements and spatial locations. Because movement and location encoding by individual neurons was so weak, it may not be such a concern for single-neuron analyses. Yet because these weak signals were so widely distributed across the population, this information was strongly represented at the ensemble level and should be considered in population analyses.
The Development of Financial Accounting Learning Tools with Gall and Borg Model
Authors: Putri Reni Sovia , Wardoyo Cipto 
Published: April 2018

This research aims to develop financial accounting learning tools namely; development of lesson plan, handouts, and learning media. The object of this research was the 11th grade students of accounting study program in Muhammadiyah 03 High Vocational School Singosari. The model of learning device development used Gall and Borg model. The stages were 1) Initial Needs Analysis; 2) Initial Product Developing; 3) Validation; 4) Product Revision I; 5) Limited Field Trial; 6) Product Revision II; 7) Field Trial; and 8) Final Product. The result of the research shows that the learning tools on financial accounting subject are valid/proper to be used. It is proven by the score of material expert judgment that is 82.8%, by the media expert that is 98.6%, by the education expert that is 86%, by the limited field trial (students and teachers ) that are 87.7% and 80.7%, and by Field trials that is 80.2%. In field trials, the development of learning tools can improve student learning outcomes. There are only 3 students who got their grades below the minimum mastery standard.
Dopamine synthesis and dopamine receptor expression are disturbed in recurrent miscarriages
Authors: Gratz Michael J , Stavrou Stavroula , Kuhn Christina , Hofmann Simone , Hermelink Kerstin , Heidegger Helene , Hutter Stefan , Mayr Doris , Mahner Sven , Jeschke Udo , Vattai Aurelia 
Published: April 2018

Objectives
l-dopa decarboxylase (DDC) is responsible for the synthesis of dopamine. Dopamine, which binds to the D2-dopamine receptor (D2R), plays an important role in the maintenance of pregnancy. Aim of our study was the analysis of DDC and D2R expression in placentas of spontaneous miscarriages (SMs) and recurrent miscarriages (RMs) in comparison to healthy controls.

Methods
Patients with SM (n = 15) and RM (n = 15) were compared with patients from healthy pregnancies (n = 15) (pregnancy weeks 7–13 each). Placental tissue has been collected from SMs and RMs from the first trimester (Department of Gynaecology and Obstetrics, LMU Munich) and from abruptions (private practice, Munich). Placental cell lines, BeWo- and JEG-3 cells, were stimulated with the trace amines T0AM and T1AM in vitro.

Results
Levels of DDC and D2R in trophoblasts and the decidua were lower in RMs in comparison to healthy controls. Stimulation of BeWo cells with T1AM significantly reduced DDC mRNA and protein levels. Via double-immunofluorescence, a DDC-positive cell type beneath decidual stromal cells and foetal EVT in the decidua could be detected.

Conclusions
Downregulation of DDC and D2R in trophoblasts of RMs reflects a reduced signal cascade of catecholamines on the foetal side.