bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulation of FLIP(L) and TRAIL-R2 signalling by the SCFSkp2Ubiquitin Ligase Complex
Authors: Roberts JZ , Holohan C , Sessler T , Fox J , Higgins C. , Espona-Fiedler G , Majkut J , Crawford N , Riley JS , Khawaja H , Humphreys LM , Ferris J , Evergren E , Moynagh P , McDade SS , Longley DB 
Published: August 2019

AbstractDepending on its expression levels, the long splice form of the pseudo-caspase FLIP (FLIP(L)) can act as an inhibitor (high expression) or activator (low expression) of apoptosis induction by the TRAIL-R2 death-inducing signalling complex (DISC); its expression levels are therefore tightly regulated. Here, we demonstrate that the Skp1-Cullin-1-F-box (SCF) Cullin-Ring E3 Ubiquitin Ligase complex containing Skp2 (SCFSkp2) regulates the stability of FLIP(L) (but not the short splice form FLIP(S)), and, unusually, this is mediated by direct binding of FLIP(L) to Cullin-1 rather than via Skp2. By fine mapping the interaction of FLIP(L) with Cullin-1 to the large subunit of its pseudo-caspase domain, we found that the interaction is significantly stronger with FLIP(L)’s DISC-processed p43-form. Importantly, this interaction disrupts the ability of p43-FLIP to interact with FADD, caspase-8 and another DISC component, TRAF2. Moreover, we find that SCFSkp2associates with TRAIL-R2 constitutively and does so independently of FLIP(L) and other canonical DISC components. Inhibition of Cullin-1 expression (using siRNA) or activity (using a NEDDylation inhibitor, MLN4924) enhanced FLIP(L) and TRAF2 levels at the TRAIL-R2 DISC and enhanced caspase-8 processing. This suggests that processing of FLIP(L) to p43-FLIP at the TRAIL-R2 DISC enhances its interaction with co-localised SCFSkp2, leading to disruption of p43-FLIP’s association with the DISC thereby altering caspase-8 processing. These findings provide important new insights into how FLIP(L) expression and TRAIL-R2 signaling is controlled.
Magnesium, aluminum and zinc co-substituted hydroxyapatite: anti-corrosion properties
Authors: Šimková Lenka , Šulcová Petra 
Published: August 2019

Purpose
The purpose of this study was to investigate the influence of doping ions Mg2+, Zn2+, Al3+ to the structure of hydroxyapatite (HAP; Ca10(PO4)6(OH)2) and subsequently to evaluate their adaptation in structure and their anticorrosive properties.

Design/methodology/approach
The substituted hydroxyapatite was synthesized by precipitation method that included the addition of Mg2+, Zn2+ and Al3+ containing precursors to partially replace Ca2+ ions in the hydroxyapatite structure. For precipitation synthesis, three ratios of Ca/P = 1; 1.67; 3 and two values of pH = 7 and 12 were selected. Samples 1 (Ca/P = 1; pH = 7), 2 (Ca/P = 1.67; pH = 7), 3 (Ca/P = 3; pH = 7) and 5 (Ca/P = 1.67; pH = 12) were chosen to monitor the influence of doping ions Mg2+, Zn2+ and Al3+ to the structure of hydroxyapatite and its anticorrosive properties.

Findings
The chosen synthesis conditions are appropriate for the formation of crystalline HAP substituted by elements Mg, Zn and Al. Only for one sample (1-Mg), two different phases (hydroxyapatite and whitlockite) were identified in the phase composition. On the basis of preliminary corrosion tests, pigments were divided into three groups pursuant to their anticorrosion effectivity: pigments with high corrosion-inhibition efficiency; pigments without anticorrosive properties; and pigments that promote corrosion processes.

Originality/value
In addition, no doping effect can be observed except for the sample 1-Mg, which consists of two phases (hydroxyapatite and whitlockite). Preliminary corrosion tests prove that some samples of HAP have extremely high anticorrosive effectivity as effectivity of the commercial pigments. The accelerated corrosion test showed that HAP samples have insufficient corrosion-inhibition properties for coating applications compared with the commercial pigment.
Transparency of public private partnership (PPP): the extent of mandatory information disclosure
Authors: Ismail Suhaiza , Musawa Mubarak Shehu , Ahmad Hawa 
Published: August 2019

Purpose
The purpose of this paper is to examine the extent public listed construction firms in Malaysia disclose mandatory information on public private partnership (PPP) projects. This paper is important as the level of disclosure of PPP information reflects the extent of transparency as practiced by the companies involved in PPP projects.

Design/methodology/approach
In achieving the aim, a content analysis procedure was carried out to analyse the 2015 annual reports of the construction companies. Descriptive statistics including the mean score, frequency and percentage were employed to analyse the disclosure of the annual report.

Findings
The overall mean disclosure score of the sampled companies is 40 per cent, which connotes a low level of disclosure of mandatory information on PPP. The companies also tend to disclose more mandatory financial information than non-financial information.

Originality/value
This paper is one of the few studies that investigated the level of mandatory disclosure of PPP information, thus contributing to the scanty literature on PPP transparency not only in Malaysia but also internationally.
Supply chain transparency and willingness-to-pay for refurbished products
Authors: Duan Yanji , Aloysius John A. 
Published: August 2019

PurposeResearchers in supply chain transparency have called to expand the boundaries by disclosing various types of information to multiple stakeholders. The purpose of this paper is to explore the effect of transparency about supply chain sustainability on consumers as critical stakeholders and investigate the effectiveness of message characteristics.Design/methodology/approachThis study utilizes two scenario-based experiments grounded in a refurbished goods context: Study 1, which employs a 2×2 between-subject experiment investigates the effects of product type and sustainable information provision on consumers evaluations, and Study 2, which employs a 2×1 between-subject experiment examines the effects of sustainable information direction on consumer evaluations. A total of 348 participants were recruited from the Amazon M-Turk platform across the two experiments. Data are analyzed with regression analysis using the PROCESS macro in SPSS and the Johnson–Neyman technique.FindingsContrary to prior research that assumes that refurbished products are associated with lower quality, quality perceptions are moderated by individuals’ environmental involvement (EI) and the information presented by the firm. More importantly, consumer evaluations are influenced by specific characteristics of sustainable supply chain messages: high EI individuals have higher willingness-to-pay a premium (WTPP) when the message is consistent with original beliefs (pro-attitudinal). In contrast to prior theory, there was no difference in the WTPP of consumers with high EI and low EI for counter-attitudinal messages.Practical implicationsThe study shows that what to say, how to say it and to whom, are critical for firms who seek to nudge consumers to support their sustainable practices.Originality/valueThe value of communicating information on sustainability has been well established. However, little is known about such association when the information provided trades off environmental benefits and product quality. This research addresses the gap in a refurbished product context. The research studies the effect of sustainable supply chain transparency and message characteristics on stakeholders’ evaluations.
Tell us a story: teaching religion with picturebooks
Authors: Gillikin Margaret Wilson , Hubbard Koti L. , Stapleton Joy N. 
Published: August 2019

Purpose
The purpose of this paper is to present a method to incorporate teaching about religion into K–12 social studies classes. A central tenet of social studies education is preparing students to be engaged citizens, and religious literacy is essential to this. Yet, teachers often feel uncomfortable teaching about religion. One way to approach this is by centering discussion about religion around understanding who our neighbors are.

Design/methodology/approach
This paper employs the Inquiry Design Model to outline lessons for early, middle and upper grades, each centered around the compelling question, “Who are my Muslim neighbors?” Beginning with a picturebook depicting a Muslim American child, the lessons explore supporting questions with academically appropriate sources, culminate with an evidence-based response to the compelling question and suggest an opportunity for students to take informed action.

Findings
While religion does not appear in many social studies standards, teaching about religion has strong connections to civics standards. In an increasingly diverse USA, students need to understand the beliefs and religious behaviors of their neighbors and how those traditions provide a sense of belonging within the faith community. This paper provides the necessary tools for teachers to teach this content. In addition to teaching these as outlined here, teachers can also select resources from across the three units in order to customize an inquiry for a particular group of students.

Originality/value
Teachers are often hesitant to teach about religion. This paper offers a concrete method for doing so. Incorporating religion into social studies classes is necessary for preparing students for civic engagement.
Developing entrepreneurial learning triggered by factory tours
Authors: Bonfanti Angelo , Castellani Paola , Giaretta Elena , Brunetti Federico 
Published: August 2019

Purpose
This paper aims to examine the content dimensions and methods of accelerating the entrepreneurial learning (EL) triggered by participating in learning events, such as factory tours. It particularly focuses on the Italian case of Open Factory – an open-doors event of industrial manufacturing culture.

Design/methodology/approach
This study adopted a qualitative approach using the “Gioia” methodology. Data were mainly collected through semi-structured interviews with firms participating in and organising Open Factory.

Findings
The dimensions of EL are learning from critical reflection, experience and external sources, while the enablers of EL (factors that accelerate learning) are varied and connected to organisational learning in the form of individual-, team- and institutional-level learning. Based on these results, this paper proposes a model for developing EL triggered by participating in learning events.

Practical implications
This research suggests developing appropriate organisational conditions inside firms, especially by entrepreneurs. These conditions are connected to sharing organisational values to foster learning, such as trust, commitment, involvement, awareness, sharing of experiences, exchange, autonomy and freedom. In addition, this study suggests ways that the EL model proposed in this research can be adapted to other learning events.

Originality/value
This is the first study to connect factory tours to learning events and EL. It highlights the ways that participating in the Open Factory event created the chance to develop learning across organisational levels inside firms.
How to intentionally forget rules in newly introduced agile projects
Authors: Volland Marcel F. 
Published: August 2019

Purpose
While much empirical research has examined how routines are unlearned, little is known about the intentional forgetting of rules in organizations. This paper aims to combine the literature on organizational rules and that on intentional forgetting with the aim of studying the relationship between power types of rule imposition and the process of intentional forgetting.

Design/methodology/approach
This study is a single-case analysis carried out in a multinational automotive company that introduced an agile project into the development department. The case was chosen because the introduction of agility was grounded on a dominantly created set of rules. Access to unique data was provided to study processes of intentional forgetting when actors have to apply new rules. In all, 33 interviews and further observations were conducted in a two-year study. Qualitative comparative analysis (QCA) was used for data analysis.

Findings
This case study demonstrates the importance of two forms of power, domination and self-organization, when it comes to forgetting rules intentionally. A rule will be intentionally forgotten if it is created by domination, does not originate from conventional working practices and does not determine an organizational unit (development team). Furthermore, the findings point to the importance of self-organization when it comes to intentional forgetting.

Research limitations/implications
This research relies on a single-case study and presents first results on intentionally forgetting rules.

Practical implications
Organizations implementing new forms of working such as agile working in their existing structures should be aware that processes of intentional forgetting can occur. Managers should consider why organizational members stop following dominantly created rules. Ignoring such a phenomenon could be a threat to the organization’s success.

Originality/value
While many studies examined the process of unlearning routines, little is known about the intentional forgetting of rules in organizations. Rules are different from routines because they are imposed and encompass a normative component. The imposition of a rule is based on power. Two forms of power are presented in this article: domination and self-organization. In addition, the QCA was carried out at a micro-level.
Postmenopausal craniofacial hyperhidrosis treated with botulinum toxin type B
Authors: Cabreus Philip , Swartling Carl , Rystedt Alma 
Published: August 2019

AbstractHyperhidrosis can seriously impair patients’ quality of life. Medical history, including heredity and hyperhidrosis during youth, as well as current age and time elapsed since menopause, is important to consider when distinguishing between postmenopausal hyperhidrosis and vasomotor symptoms to enable adequate treatment. This report concerns a subgroup of eight postmenopausal patients participating in a randomized controlled trial regarding botulinum toxin (Btx) type B treatment in craniofacial hyperhidrosis. Even though the sample size is small and the enrolment is not yet completed, the promising data collected hitherto are interesting to present in advance because this subtype of craniofacial hyperhidrosis is often underrecognized and challenging to treat. Patients were randomized to receive Btx type B or placebo. Measurements were performed before treatment and 3 ± 1 weeks after. The Dermatology Life Quality Index (DLQI) score was improved for all patients after Btx type B treatment (n = 3) with a median decrease of 9 points (90% median improvement). The placebo group (n = 5) had a median increase of 2 points (–18% median decline). When the same group (n = 5) received Btx type B (open) the DLQI score decreased with a median of 7 points compared with baseline (91% median improvement). Treatment‐related adverse events were temporary and did not prevent improvement of life quality. Furthermore, background data evaluation uncovered interesting findings regarding vasomotor symptoms in relation to postmenopausal hyperhidrosis. In conclusion, the results indicated that Btx type B seems to be a safe and effective treatment in postmenopausal craniofacial hyperhidrosis. Further research is encouraged.
Litter quality and site characteristics interact to affect the response of priming effect to temperature in subtropical forests
Authors: Lyu Maokui , Nie Yangyi , Giardina Christian P. , Vadeboncoeur Matthew A. , Ren Yinbang , Fu Zuoqin , Wang Minhuang , Jin Changshan , Liu Xiuming , Xie Jinsheng 
Published: August 2019

Abstract

Forest litter inputs to soil can stimulate the decomposition of older soil organic matter (SOM) via a priming effect (PE). The magnitude and underlying mechanisms driving PE are poorly understood, with especially little know about how litter quality and site conditions affect PE in situ. Further, very few studies have examined PE in tropical and subtropical soils.

Here, we established low and high elevation sites (600 vs. 1,400 m a.s.l.) in the subtropical Wuyishan National Park, China, that differed with respect to mean annual temperature (MAT; ∆MAT = 4.2°C), vegetation, soil texture and soil moisture. We conducted a 1‐year field incubation study at these two sites to compare PE induced by adding low‐ and high‐quality 13C‐labelled leaf litter to soils.

At the low elevation site, additions of high‐quality (low C/N) litter caused a PE that was 140% greater than the PE observed following additions of low‐quality (high C/N) litter. In contrast, we saw no significant differences in PE between litter types at the high elevation site, perhaps because PE was not limited by substrate quality at this cooler, finer textured and higher soil moisture coniferous site. In addition, we found a negative relationship between home‐field advantage (HFA) for litter decomposition and PE, indicating that specialized litter decomposer community driving HFA may not accelerate SOM decomposition via PE in the same way.

In line with our observed strong relationship between PE and the efficiency of priming (PE size per unit of mineralized litter C), PEs induced by the high‐ and low‐quality litters were directed to microbial phosphorus (P) mining rather than nitrogen (N) mining. This interpretation aligns with observed increases in the activity of P acquiring extracellular enzymes, often described as phosphatases (P‐tases), as well as the positive relationship between the PE, P‐tase activity and the activity of C acquiring extracellular enzymes.

Overall, this PE study across two contrasting sites highlights the important role of site characteristics and litter quality in regulating PE size. Further, we suggest that MAT may be a dominant driver of soil priming, through both the direct effects of litter quantity on labile substrate supply and the indirect effects of litter quality changes on downstream decomposer communities.

A free Plain Language Summary can be found within the Supporting Information of this article.
Correlation between the shoot‐cutting behavior of the acorn weevil and the reproductive traits of host fagaceous trees
Authors: Hirayama Daisuke , Okada Minetaka , Nanami Satoshi , Itoh Akira 
Published: August 2019

AbstractMany fagaceous species mature acorns during the second autumn after flowering and are called “2‐year species.” In 2‐year species of subgenus Cyclobalanopsis (genus Quercus), alternate bearing (2‐year seed production cycle) is prominent, but this has not been reported for other 2‐year species in the genera of Lithocarpus and Castanopsis. We tested the hypothesis that the difference in reproduction of 2‐year species is linked to the weevil, Mechoris ursulus. After ovipositing on acorns, this insect cuts the shoots to which the acorns are attached. We examined the host preference of M. ursulus and reproductive traits of fagaceous 2‐year species. Percentage infestation was remarkably high in the subgenus Cyclobalanopsis, whereas Lithocarpus and Castanopsis species suffered almost no damage. Furthermore, unlike Lithocarpus and Castanopsis, most of the acorn‐producing shoots in subgenus Cyclobalanopsis had no current‐year shoots. The clear relationship suggests that alternate bearing in subgenus Cyclobalanopsis is an adaptation to the shoot‐cutting behavior of M. ursulus.
Short‐term outcomes of typical versus atypical lung segmentectomy by minimally invasive surgeries
Authors: Xie Boheng , Sun Xiao , Qin Yi , Liu Ao , Miao Shuncheng , Jiao Wenjie 
Published: August 2019

BackgroundSegmentectomy is increasingly used to resect lung nodules. Robotic‐assisted thoracic surgery (RATS) is considered a safe and practical method for segmentectomy. Few studies have compared robotic surgery and video‐assisted thoracic surgery (VATS) for lung segmentectomy.MethodWe retrospectively examined 215 consecutive patients who underwent typical (88 patients) or atypical (128 patients) segmentectomy by either robotic surgery or VATS. The postoperative characteristics including operation time, blood loss, pneumonia, tumor size, lymph nodes harvested, chest tube duration, prolonged air leak, atrial fibrillation, and postoperative hospital stay were recorded.ResultsA total of 88 patients underwent typical segmentectomy, while 127 patients underwent atypical segmentectomy. A greater number of lymph nodes were resected via RATS than by VATS (13.24 ± 4.84 vs. 11.71 ± 3.89; P = 0.018). The operation time for typical segmentectomy was shorter than that for atypical segmentectomy (115.69 ± 22.32 vs. 131.68 ± 22.52; P = 0). No significant differences were found between RATS and VATS in terms of chest drainage duration and postoperative hospital stay. The incidence of postoperative complications including prolonged air leak and atrial fibrillation was not significantly different between typical segmentectomy and atypical segmentectomy.ConclusionAtypical segmentectomy is more complicated than typical segmentectomy, which may lead to increases in complications and operation time. Robotic surgery was safe and practical for segmentectomy compared to VATS and more lymph nodes could be dissected by RATS without increasing the risk of postoperative complications.
Trade credit use and bank loan access: an agency theory perspective
Authors: Ma Liangbo , Ma Shiguang 
Published: August 2019

AbstractIn this study we find that firms’ use of trade credit significantly facilitates their access to bank loans in the future, suggesting a complementary relationship. Such a relationship is more profound for firms with higher perceived agency costs, i.e., firms with opaque corporate information, firms located in regions with less developed external institutions, and firms at an early stage of existence. Firms switch from trade credit to bank loans as the main source of debt financing as they age. However, the process is slower for firms with a greater level of corporate information opacity and firms located in regions with weak external institutions.
Thymic hyperplasia following double immune checkpoint inhibitor therapy in two patients with stage IV melanoma
Authors: Mencel Justin , Gargett Tessa , Karanth Narayan , Pokorny Adrian , Brown Michael P. , Charakidis Michail 
Published: August 2019

AbstractHyperplasia of the thymus is commonly seen in myasthenia gravis and other autoimmune disorders. Thymic size also varies with age, corticosteroid use, infections, and inflammatory disease. Although thymic hyperplasia has been described following chemotherapy, there is no known association of true thymic hyperplasia with immune checkpoint inhibitor therapy. We present two cases of suspected true thymic hyperplasia in patients with stage IV melanoma who were treated with the combination of nivolumab and ipilimumab, which was complicated by immune‐related toxicity requiring corticosteroid therapy, and then subsequently also by secondary hypoadrenalism requiring replacement hydrocortisone. In one patient, histological and flurocytometric analyses of an incisional biopsy of the thymus revealed findings consistent with true thymic hyperplasia. In the other case, the stable fluorodeoxyglucose positron emission tomography/Computed tomography (FDG‐PET/CT) findings were consistent also with true thymic hyperplasia. These are the first described cases of true thymic hyperplasia following combination immune checkpoint inhibitor therapy for metastatic melanoma. We hypothesize that the true thymic hyperplasia in these cases results from initial lymphocyte depletion caused by intense corticosteroid therapy followed by rebound thymic hyperplasia during the period of relative hypocortisolism, which may have been aggravated by the onset of secondary hypoadrenalism.