bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Tale of Cross-Dataset Analysis on Mental Health
Authors: Emran Abdullah Nayem Wasi , Islam A. B. M. Alim Al 
Published: October 2024

Abstract

Even though recent days present several different datasets on mental health, conventional studies generally limit their scope to specific datasets within isolated contexts, leaving gaps in our understanding of how mental health evolves across different contexts. Therefore, going beyond such conventional studies, we examine three different mental health-related datasets – covering medical students, quarantined individuals, and those with psychiatric disorders – to offer comprehensive knowledge through a cross-dataset lens. In our study, using statistical and network-based analyses, we explore how age, gender, and education affect mental health outcomes in varying contexts. While isolated analyses of our considered datasets reveal important patterns, such as women experiencing heightened stress in quarantine and medical students displaying increased empathy, our cross-dataset analysis uncovers novel and unexpected insights. For instance, our cross-dataset analysis reveals that the impacts of age on mental health substantially vary during quarantine and in clinical settings. Additionally, although education is typically believed to be associated with better mental health, we find that this association does not hold for medical students. These findings underscore the value of cross-dataset analysis for offering richer insights into how external factors impact mental health across diverse contexts, providing valuable guidance for future research and interventions.
Uncovering the Relationship Between Technology-Enhanced, Adaptive Teaching and Situational Interest in Mathematics in a Randomized Controlled Trial
Authors: Fütterer Tim , Hoch Emely , Dumont Hanna 
Published: November 2024

Abstract

Previous research has shown that students’ interest typically declines across secondary school, likely resulting from a mismatch between their needs and the school environment. Technology-enhanced adaptive teaching may allow teachers to better tailor their instruction to students’ needs, including students’ interests; thus, this approach may be promising in this regard. The objective of this study was to gain insight into the associations between equipping students and their teachers with tablet computers (1:1 technology), student-perceived adaptive teaching, and students' situational interest. We used questionnaire data (i.e., from two measurement points: t0 = baseline; t1 = 4 months later) from the longitudinal project tabletBW meets science from 2,601 students (Grade 7, Gymnasium, Germany) attending 28 schools. Fourteen schools were randomly chosen to be given 1:1 technology (i.e., tablet computers for teachers and students; intervention condition). The other 14 randomly chosen schools were not given such equipment (control condition). We assessed how students' situational interest in mathematics was associated with the use of tablet computers (intervention vs. control) and student-perceived adaptive teaching. Results from multilevel models showed that the 1:1 technology had a statistically significant effect on students' situational interest, partly mediated by student-perceived adaptive teaching. Moreover, knowing that students' interest in math declines in adolescence, our results indicate that equipping classrooms with technology might offer a promising way to implement more adaptive lessons that have the potential to provide the appropriate degree of challenge to students and thus spark their interest in mathematics.
Mechanical thrombectomy of acute ischemic stroke of Medium Sized Vessels (M2 segment of middle cerebral artery occlusion)
Authors: Khedr Eman M. , Elbassiouny Ahmed , Nageeb Mahmoud , Aly Ahmed , Mohamed Khalid O. , Haridy Nourelhoda A. 
Published: November 2024

Abstract

Background
Data on mechanical thrombectomy (MT) to treat M2 occlusions of the middle cerebral artery (MCA) are sparse. We report the outcome and safety of MT versus intravenous recombinant tissue plasminogen activator (IV rTPA) versus conventional medical treatment of acute ischemic stroke (AIS) due to occlusion of the M2 segment of the MCA. This prospective study compared the outcomes and safety of MT, rTPA, and conventional medical treatment in M2 occlusion AIS patients. National Institutes of Health Stroke Scale (NIHSS), Modified Rankin Scale (mRS), and recanalization rate assessed outcomes.
Results
74 AIS patients were recruited (23 MT, 23 rTPA, 28 conventional treatments). MT group had significantly higher admission NIHSS (p = 0.037). At 24 hours, NIHSS improved more with MT and rTPA than conventional treatment (p < 0.0001). At 3 months, mRS were better with MT and rTPA versus conventional treatment (p < 0.0001). Successful recanalization occurred in 73.9% of the MT group. 69% of the MT group required stent retrieval plus aspiration thrombectomy and 60.9% required ≥ 3 trials, but outcomes did not differ by technique or number of trials. A good outcome (mRS 0–2) at 3 months was achieved in 69.6% MT versus 65.2% rTPA versus 7.1% conventional treatment (p < 0.0001). Symptomatic intracranial hemorrhage (sICH) rates were slightly, but insignificantly, higher with conventional treatment. Mortality did not significantly differ between groups.
Conclusions
For M2 occlusions, MT and rTPA achieved better early and 3-month outcomes than conventional management, however, MT was not superior to rTPA. MT of M2 is feasible and effective, with a lower hemorrhage rate than rTPA and conventional treatment.
Trial registration
This study was prospectively registered in the clinical trial with ClinicalTrials.gov ID (NCT05091320). The link https//clinicaltrials.gov/study/NCT05091320
Down-regulation of YAP prevents smoking- and alcohol-induced carcinogenesis of esophageal paracancerous tissue by promoting cellular pyroptosis
Authors: Ding Xinyu , Li Ying , Wang Xuning , Li Fan , Xu Zhifei , Zhu Yongfei , Chen Zihao 
Published: November 2024

Abstract

Background
Paracancerous tissues (PCTs) were previously considered benign regions, but recent findings reveal genomic instability in these areas. Smoking and alcohol consumption are closely associated with esophageal cancer (EC) development. This study explored the interplay between the Hippo pathway and pyroptosis in EC, PCTs, and distal normal tissues (DNTs).
Methods
We used molecular epidemiological methods to analyze the effects of smoking and alcohol on these pathways. We found that key genes in both pathways were more altered in smokers and/or drinkers compared to non-smokers and non-drinkers. Additionally, we observed changes in some genes and proteins in PCTs, while the Hippo pathway and pyroptosis had not yet been influenced. We applied 4.0% alcohol combined with various concentrations of cigarette smoke extract (CSE) to PCTs cultured in vitro to observe carcinogenesis and changes in these pathways. Verteporfin, as an inhibitor of YAP, was also used in vitro culture experiments to observe its effects on cellular carcinogenesis.
Results
Among 56 EC patients, 41 had a history of smoking and/or alcohol consumption in this study. Significant alterations in Hippo pathway genes (LATS1, YAP, TAZ) and pyroptosis genes (NLRP3, ASC, GSDMD, Caspase-1) were observed in EC tissues and change of Lats1, Nlrp3, and Asc in PCTs. We also found verteporfin inhibited CSE and alcohol-induced carcinogenesis by downregulating YAP and promoting pyroptosis.
Conclusions
It is speculated that the downregulation of YAP could prevent smoking- and alcohol-induced carcinogenesis in esophageal PCTs by promoting pyroptosis, which may offer new insights for the treatment of esophageal squamous carcinoma.
Malaria risk factors amongst forest going populations in Mondulkiri Province and Kampong Speu Province, Cambodia: a large cross-sectional survey
Authors: Chen Ingrid , Doum Dyna , McIver David J , Keo Vanney , Vong Pisey , Pech Sophak , Meth Vanny , Bun Sour , Pen Kimheng , Chea Sopagna , Ly Kanha , Hok Kry , Sovannaroth Siv , Ting Jafit , Lovin Diana , Cunningham Joanne , Vajda Elodie , Tatarsky Allison , Lobo Neil F 
Published: November 2024

Abstract

Background: Cambodia strives to eliminate all species of human malaria by 2025, requiring that foci among forest-exposed populations in remote settings be addressed. This study explores malaria risk factors amongst forest-exposed groups in Mondulkiri and Kampong Speu Provinces, Cambodia as part of a multi-stage study on novel bite prevention tools (Project BITE).
Methods: A serial cross-sectional survey explored the demographics, housing structure openness, mosquito bite prevention habits, and gaps in protection amongst three target groups: forest goers who work in the forest, forest dwellers who live in the forest, and forest rangers who patrol forested regions. Malaria prevalence data was collected at three time points using rapid diagnostic tests (RDTs) for febrile individuals and qPCR for all participants. Infection locations and travel patterns of P. falciparum-infected individuals were analyzed for clustering and the potential movement of infections.
Results: 2,935 participants were enrolled between October 2022 and February 2023, consisting of 1,093 (37%) forest goers and 1,787 (61%) forest dwellers across both provinces, and 55 (5%) forest rangers in Mondulkiri province. Most worked outdoors as farmers, day laborers, and forest collectors, and reported going to the forest five to seven days a week. For housing, 29% and 39% of participants reported living in partially open primary and secondary structures, respectively. The main methods of mosquito bite protection used were insecticide-treated nets, wearing long sleeves, and burning mosquito coils, with gaps in protection during the daytime and outside at night. All febrile individuals had negative RDT test results. For qPCR, 24 P. falciparum infections (<1%) were detected among forest goers and dwellers, clustered in Pu Trom and Pu Nhav villages in Mondulkiri Province, and Banteay Roka and Banteay Roka Kirisenchey (M) villages in Kampong Speu Province. P. vivax cases were detected (216 cases, 5%) across all enrolled villages. Only two infections were found in forest rangers.
Conclusion: Malaria elimination strategies for forest-exposed populations in Cambodia should focus on vector intervention strategies that offer protection during the day and outside at night, and the use of drug-based strategies to clear subpatent infections, targeting forest goers and dwellers in villages where cases are detected.
Immunomodulatory effect of metabolites secreted by the probiotic strain of E. coli O83:K24:H31
Authors: Černý Viktor , Inic-Kanada Aleksandra , Krčmářová Eliška , Novotná Olga , Petrásková Petra , Súkeníková Lenka , Kuzma Marek , Schabussova Irma , Hrdy Jiri 
Published: October 2024

Abstract

Bacteria and their metabolic products profoundly affect the immune system. Research has shown that early postnatal supplementation with specific probiotic strains, such as Escherichia coli O83:K24:H31 (EcO83), can provide health benefits. EcO83 is a facultative anaerobe capable of generating energy through multiple metabolic pathways, an adaptation that allows it to thrive in the gastrointestinal tract where oxygen availability can vary. Despite these advantages, the precise mechanisms through which this probiotic, and in particular its metabolites, functions remain largely unknown. In this study, we aimed to identify the metabolites that EcO83 produces when cultured under both aerobic and anaerobic conditions. We also aimed to investigate the immunomodulatory effects of these metabolites on human peripheral blood mononuclear cells (PBMCs), mouse splenocytes, and bone marrow-derived dendritic cells (BMDCs) in vitro. Our results revealed the presence of short-chain fatty acids (SCFA), namely acetate and propionate, in the supernatants of both aerobic and anaerobic EcO83 cultures. Interestingly, the supernatants from the aerobic cultures induced greater production of Th1 cytokines, such as IFN-γ, in PBMCs, whereas anaerobic culture supernatants more prominently triggered the Th2 cytokine IL-13. Similarly, murine splenocytes exhibited increased IFN-γ production when stimulated with aerobic supernatants. Additionally, both aerobic and anaerobic EcO83 supernatants promoted the release of proinflammatory (TNF-α) and anti-inflammatory (IL-10) cytokines from the BMDCs, as well as their maturation, evidenced by the upregulation of surface marker CD80. In conclusion, we are the first to report that EcO83 produces SCFA, including acetate and propionate, under varying oxygen conditions. Our findings suggest that probiotics can exert beneficial effects through their secreted metabolites, not solely through the presence of the bacterial cells themselves, making them a promising postbiotic solution for therapeutic administration.
Efficient and stable blue perovskite light-emitting diodes through I-III-VI quantum dot solids as hole transport layer
Authors: Zheng Xue , Wang Yuanzhi , Zhong Guo-Hua , Chen Ming , Shao Yan , Ming Wenjie , Ren Chuanlai , Wu Qianqian , Liu Minqiang , Wang Haoran , Zhang Jie , Bai Yang , Hou Wenjun , Yang Chunlei 
Published: November 2024

Abstract

Perovskite light-emitting diodes (PeLEDs) have achieved skyrocketing progress in material and device efficiencies. However, inferior stabilities of pure blue devices, remain major hurdles towards full-color displays. Herein, we built PeLEDs based on quasi-two-dimensional (quasi-2D) perovskites using chalcopyrite I-III-VI semiconductor quantum dot (QD) solids as novel inorganic hole transport layer (HTL), to overcome the stability issues in blue PeLEDs. Wide-gap silver-copper-gallium-disulfide (ACGS) QDs were dedicatedly-synthesized aiming for enhanced hole transport efficiency in QD solids through adaptable band structure and surface chemistry engineering, resulting in band-like hole transport with a high mobility of 0.546 cm2 V− 1s− 1 in the linear working scheme. In addition, the Lewis base group attached to the QD surface (Cl−, RS−) lower the defect density through buried interface passivation on uncoordinated Pb2+ in perovskite, which effectively regulate crystallization kinetics of quasi-2D perovskite. Furthermore, halide interstitial defects were stabilized by Lewis acids group (Zn2+) capped on the surface of ACGS QDs, preventing ionic migration and deep-level trap formation. As a result, the champion pure-blue PeLEDs based on ACGS QD solids exhibit preeminent operating lifetime (T50@100 cd/m2 = 78 min) for electroluminescence (EL) peak emission wavelength at 471 nm, with maximum external quantum efficiency (EQE) of 10.85%.
Qualitative study of drinking water, sanitation, and hygiene access: perspectives from the Central Gonja District, Ghana, and Mtubatuba Municipality, South Africa
Authors: Bazaanah Prosper , Buthelezi Smangele Johanna , Afua Kobe Oppong Dina 
Published: November 2024

ABSTRACT

Water, sanitation, and hygiene (WASH) are essential for human development. Lack of WASH facilities affects livelihoods and health of communities. Assessing the state, availability, and accessibility of WASH systems is vital for identifying gaps and formulating proactive solutions. This study assessed drinking water and sanitation access in the Central Gonja District (CGD) and Mtubatuba Municipal areas, using qualitative methods and in-depth interviews with participants. Findings revealed persistent challenges of inadequate, unaffordable, and inaccessible water, along with subpar sanitation services, negatively impacting community well-being and health. Issues like corruption, favouritism, and social networks influenced distribution of water and sanitation systems. Infrastructure limitations, bureaucratic obstacles, and ineptitude of officials posed barriers to service delivery, exacerbated by rural -urban population shifts. A public -private partnership between Novubu and Mtubatuba Municipality enabled water treatment, showcasing a potential model for sustainable water provision and possible replication for CGD. The study advocates for transparent governance, community-centric solutions, and inclusive strategies to address chronic challenges, emphasizing the importance of proactive leadership and maintenance to prevent environmental degradation and health risks. The local governance systems should ensure the distribution and maintenance of water and sanitation systems while emphasizing the need for inclusive, community-driven approaches for lasting improvements.
Categorization and multi-criteria analysis of heat wave vulnerability in Senegal
Authors: Sow Moussa , Gaye Demba 
Published: November 2024

ABSTRACT

Climate variability is reflected in different ways in different parts of the world. The Sahel is one of the area's most vulnerable to climatic extremes, particularly heat waves. The objective of the present study is to categorize heat waves and analyze their geographic vulnerability. The methodology sought to analyze the categories of the 2,378 heat waves observed over the period between 1984 and 2020 from 40 stations and to study their seasonality. Heat waves were found to be very common, with a high degree of spatial variability. Seasonally, they are divided into 2,166 moderate heat waves, 202 strong, and 10 severe heat waves. In addition, there is considerable seasonal variability in heat extremes. The seasonal frequency is 28.34% in summer, 27.58% in spring, 27.10% in autumn, and 16.82% in winter. The peak periods are spring (April–May–June) and summer (July–August–September). The northern and eastern regions are strongly marked by the frequency of hot extremes, whose characteristics are harsher, resulting in temperatures exceeding the 95th percentile by around 4 °C.
Potential Anti-Senescence Effect of Extract from Andrographis paniculata Herbal Plant and Its Bioactive Compounds: A Systematic Review
Authors: Khatimah Nurul Gusti , Arozal Wawaimuli , Barinda Agian Jeffilano , Antarianto Radiana Dhewayani , Hardiany Novi Silvia , Shimizu Ippei , Fadhillah Muhamad Rizqy 
Published: November 2024

The rapid aging of the global population is a major worldwide issue because of the close relationship between age and the development of several diseases. Aging or senescence is among the most widely studied topics at the moment. However, no pharmaceuticals have been developed that claim to possess anti-senescence properties. Andrographis paniculata, is a medicinal plant found widely throughout tropical and subtropical Asia. This review aims to identify the potential anti- senescence effect of A. paniculata extract and its bioactive compounds. By following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, five databases were used and in vivo and in vitro studies were included in this review. A. paniculata extracts and their bioactive compounds exert anti-senescence properties through their anti-inflammatory and antioxidant properties. This herb and its compounds enhanced memory, cognitive function and behaviour in Alzheimer's disease. The extract also promoted cell cycle progression and proliferation in the skin. In addition, andrographolide exhibited anti-senescence effects in endothelial cells through the activation of PI3K/Akt/Nrf and PI3K/Akt/AP-1 pathways. A. paniculata along with its bioactive compounds including andrographolide and 14-deoxyandrographolide, may have the potential to be used as anti-senescence through anti-inflammatory and antioxidant properties. However, the specific markers to evaluate the senescence are necessary to be conducted. Any clinical trials should be done to establish these findings. Since in clinical settings this potential herbal may be used for long-life time, the safety profile and toxicity of A. paniculata should be considered. Keywords: herbal plants, Andrographis paniculata, andrographolide, bioactive compounds, senescence
An Insight into the Structure-activity Relationship of Benzimidazole and Pyrazole Derivatives as Anticancer Agents
Authors: Patil Shital M. , Nikalje Piyush , Gavande Navnath , Asgaonkar Kalyani D. , Rathod Vaishnavi 
Published: November 2024

Introduction:
Cancer is a leading cause of death worldwide, driving the urgent need for
new and effective treatments. Benzimidazole and pyrazole derivatives have gained attention for
their potential as anticancer agents due to their diverse biological activities. The development of
resistance in cancer cells, toxicity concerns, and inconsistent efficacy across different types of cancer
are a few of the challenges. To overcome these challenges, optimisation of these nuclei using
the structure-activity relationships is necessary.

Objective:
This review aimed to examine various benzimidazole, pyrazole, and their hybrid derivatives
by focusing on their structure-activity relationships (SAR) as anticancer agents. Results of the
most potent and least potent benzimidazole, pyrazole compounds, and their hybrid derivatives published
by researchers were compiled.

Methods:
The findings of different researchers working on benzimidazole and pyrazole nuclei
were reviewed and analysed for different targets and cell lines. Moreover, substitutions on different
positions of pyrazole, benzimidazole, and their hybrid were summarised to derive an optimised
pharmacophore

Results:
Based on our analysis of existing studies, we anticipate that this review will guide researchers
in creating potent pyrazole, benzimidazole, and hybrid derivatives crucial for combating
cancer effectively.

Conclusion:
Structure-Activity Relationship (SAR) studies can help in developing pyrazolebenzimidazole
hybrids that are more powerful and selective in targeting specific aspects of cancer.
A Case Report of Gastric Oral Contrast-enhanced Ultrasonography in the Diagnosis of Eosinophilic Gastroenteritis in Adults
Authors: Qiu Lanyan , Liu Dong 
Published: October 2024

Introduction:
Eosinophilic gastroenteritis (EGE) is a rare immune-mediated chronic inflammatory disorder, which is classified into 3 types according to the
affected gastric wall layer. The serosal-type EGE is the least common type. Gastric oral contrast-enhanced ultrasonography (OCEUS) may show
some specific changes in the serosal-type EGE. Herein, we reported OCEUS findings in a serosal-type EGE case.

Case Presentation:
A 60-year-old man with unexplained abdominal pain accompanied by diarrhea, which lasted for half a month, consulted the hospital. Laboratory
findings revealed peripheral eosinophilia and elevated carbohydrate antigen 125(CA125). OCEUS showed a thickened gastric antrum wall and
ascites, with distinct layers (thickening of the muscularis propria layer was most obvious), which is rare and specific. Endoscopy showed normal
mucosa of the esophagus and stomach and scattered hyperemia spots in the mucoua of the duodenal bulb and small intestine. Microscopy
evaluation revealed few eosinophils infiltration in the lamina propria. A large number of eosinophils were seen in peritoneal lavage fluid and the
greater omentum. Eventually, the patient was diagnosed with serosal type EGE.

Conclusion:
Significant thickening of the digestive tract walls and ascites at ultrasonography (US)-examination, with distinct layers and predominant thickening
of the muscularis propria layer at OCEUS, can indicate EGE.