bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-institutional Development and External Validation of a Nomogram to Predict Recurrence After Curative Resection of Pancreatic Neuroendocrine Tumors
Authors: Pulvirenti Alessandra , Javed Ammar A. , Landoni Luca , Jamieson Nigel B. , Chou Joanne F. , Miotto Marco , He Jin , Gonen Mithat , Pea Antonio , Tang Laura H. , Nessi Chiara , Cingarlini Sara , D’Angelica Michael I. , Gill Anthony J. , Kingham T. Peter , Scarpa Aldo , Weiss Matthew J. , Balachandran Vinod P. , Samra Jaswinder S. , Cameron John L. , Jarnagin William R. , Salvia Roberto , Wolfgang Christopher L. , Allen Peter J. , Bassiy Claudio 
Published: September 2019

Objective:
To develop a nomogram estimating the probability of recurrence free at 5 years after resection for localized grade 1 (G1)/ grade 2 (G2) pancreatic neuroendocrine tumors (PanNETs).

Background:
Among patients undergoing resection of PanNETs, approximately 17% experience recurrence. It is not established which patients are at risk, with no consensus on optimal follow-up.

Method:
A multi-institutional database of patients with G1/G2 PanNETs treated at 2 institutions was used to develop a nomogram estimating the rate of freedom from recurrence at 5 years after curative resection. A second cohort of patients from 3 additional institutions was used to validate the nomogram. Prognostic factors were assessed by univariate analysis using Cox regression model. The nomogram was internally validated using bootstrap resampling method and on the external cohort. Performance was assessed by concordance index (c-index) and a calibration curve.

Results:
The nomogram was constructed using a cohort of 632 patients. Overall, 68% of PanNETs were G1, the median follow-up was 51 months, and we observed 74 recurrences. Variables included in the nomogram were the number of positive nodes, tumor diameter, Ki-67, and vascular/perineural invasion. The model bias-corrected c-index from the internal validation was 0.85, which was higher than European Neuroendocrine Tumors Society/ American Joint Committee on Cancer 8th staging scheme (c-index 0.76, P = <0.001). On the external cohort of 328 patients, the nomogram c-index was 0.84 (95% confidence interval 0.79–0.88).

Conclusion:
Our externally validated nomogram predicts the probability of recurrence-free survival at 5 years after PanNETs curative resection, with improved accuracy over current staging systems. Estimating individual recurrence risk will guide the development of personalized surveillance programs after surgery.
Engineering of membrane complex sphingolipids improves osmotic tolerance of Saccharomyces cerevisiae
Authors: Zhu Guoxing , Yin Nannan , Luo Qiuling , Liu Jia , Chen Xiulai , Liu Liming , Wu Jianrong 
Published: September 2019

ABSTRACTIn order to enhance the growth performance of S. cerevisiae under harsh environmental conditions, mutant XCG001, which tolerates up to 1.5M NaCl, was isolated via adaptive laboratory evolution (ALE). Comparisons made via transcriptome data of XCG001 and the wild-type strain identified ELO2 as being associated with osmotic tolerance. Overexpression of ELO2 increased the contents of inositol phosphorylceramide (IPC, t18:0/26:0), mannosylinositol phosphorylceramide (MIPC, t18:0/22:0(2OH)), MIPC (d18:0/22:0), MIPC (d20:0/24:0), mannosyldiinositol phosphorylceramide (M(IP)2C, d20:0/26:0), M(IP)2C (t18:0/26:0(2OH)) and M(IP)2C (d20:0/26:0(2OH)) by 88.3-, 166.9-, 63.3-, 23.9-, 27.9-, 113.8- and 208.1-fold at 1.0 M NaCl, respectively, compared those of strain XCG002. As a result, membrane integrity, cell growth and cell survival of the ELO2 overexpression strain (XCG010) increased by 24.4%, 29% and 22.1% at 1.0 M NaCl, respectively, compared those of strain XCG002. The findings provided a novel strategy for engineering complex sphingolipids to enhance osmotic tolerance.IMPORTANCEThis study demonstrated a novel strategy for manipulation membrane complex sphingolipids to enhance S. cerevisiae tolerance to osmotic stress. Osmotic tolerance was related to sphingolipid acyl chain elongase, Elo2, via transcriptome analysis of the wild-type strain and an osmotic tolerant strain generated from ALE. Overexpression of ELO2 increased complex sphingolipid with longer acyl chain, thus improved membrane integrity and osmotic tolerance.
Microbiome Stability with Chronic SIV Infection in AIDS-resistant Sooty Mangabeys
Authors: Bochart RM , Tharp G , Jean S , Upadhyay AA , Crane MM , Vanderford TH , Ortiz AM , Ericsen A , Cohen JK , Bosinger SE 
Published: September 2019

AbstractSooty mangabeys (SMs) are a natural host species of simian immunodeficiency virus (SIV) and avoid acquired immune deficiency syndrome (AIDS) despite persistently high viral loads, making them a pivotal research model for HIV pathogenesis. Unlike pathogenic SIV infection of macaque species, or HIV infection of humans, SIV-infected SMs maintain gastrointestinal barrier integrity. Here, we characterize the gastrointestinal bacterial microbiota of SIV-infected and uninfected SMs and perform a comparative analysis of diet-matched, rhesus macaques (RM). We assessed the fecal microbiome in fifty SM and thirty RM in total, and conducted analyses of the effect of SIV-status, species, and housing. When examining indoor-outdoor and indoor-only housing in our SM cohorts, biodiversity reduction and mild phylogenetic taxonomic perturbances were present. No statistically relevant differences were seen for biodiversity richness and evenness, or phylogenetic taxonomic communities between SIV negative and positive SM cohorts. In contrast, with pathogenic early chronic SIV infections in RM a trend of alpha diversity loss and increase of beta diversity and few phyla taxonomic communities differed. Lastly, we observed lower levels of pathobiont bacterial communities in SIV-uninfected SMs relative to RMs. These data suggest that the pre-existing bacterial community structure may contribute to the divergent phenotype between SIV natural hosts and pathogenic macaque species.ImportanceHuman immunodeficiency virus remains a global concern. The sooty mangabey (SM) monkey is an important biomedical research model for understanding HIV pathogenesis due to its ability to avoid AIDS disease progression despite high viremia. In people living with HIV, gastrointestinal dysbiosis towards enrichment of pathobiont communities has been frequently reported. In this study we characterized the fecal microbiota of a primate non-pathogenic SIV host, the SM, and made direct comparisons to a pathogenic SIV host species, the rhesus macaque. We observed that SMs exhibit stability of the microbiota community into chronic SIV infection, which contrasts with SIV-infected rhesus macaques, in which we observed bacterial community divergence relative to uninfected animals. Collectively, our observation of stabilization of beneficent taxa in the mucosa of AIDS-resistant primates suggests that therapeutic strategies to enrich these communities may have potential for ameliorating the gastrointestinal inflammation in people living with HIV.
First evidence of host range expansion in virophages and its potential impact on giant viruses and host cells
Authors: Mougari Said , Chelkha Nisrine , Sahmi-Bounsiar Dehia , Di Pinto Fabrizio , Colson Philippe , Abrahao Jonatas , La Scola Bernard 
Published: September 2019

AbstractVirophages are satellite-like double stranded DNA viruses whose replication requires the presence of two biological entities, a giant virus and a protist. In this report, we present the first evidence of host range expansion in a virophage. We demonstrated that the Guarani virophage was able to spontaneously expand its viral host range to replicate with two novel giant viruses that were previously nonpermissive to this virophage. We were able to characterize a potential genetic determinant of this cross-species infection. We then highlighted the relevant impact of this host adaptation on giant viruses and protists by demonstrating that coinfection with the mutant virophage abolishes giant virus production and rescues the host cell population from lysis. The results of our study help to elucidate the parasitic lifestyle of virophages and their interactions with giant viruses and protists.
Mobile agent-based SIEM for event collection and normalization externalization
Authors: Moukafih Nabil , Orhanou Ghizlane , Elhajji Said 
Published: September 2019

Purpose
This paper aims to propose a mobile agent-based security information and event management architecture (MA-SIEM) that uses mobile agents for near real-time event collection and normalization on the source device. The externalization of the normalization process, executed by several distributed mobile agents on interconnected computers and devices, proposes a SIEM server dedicated mainly for correlation and analysis.

Design/methodology/approach
The architecture has been proposed in three stages. In the first step, the authors described the different aspects of the proposed approach. Then they implemented the proposed architecture and presented a new vision for the insertion of normalized data into the SIEM database. Finally, the authors performed a numerical comparison between the approach used in the proposed architecture and that of existing SIEM systems.

Findings
The results of the experiments showed that MA-SIEM systems are more efficient than existing SIEM systems because they leave the SIEM resources primarily dedicated to advanced correlation analysis. In addition, this paper takes into account realistic scenarios and use-cases and proposes a fully automated process for transferring normalized events in near real time to the SIEM server for further analysis using mobile agents.

Originality/value
The work provides new insights into the normalization security-related events using light mobile agents.
A business ecosystem perspective of supply chain justice practices
Authors: Liu Gordon , Aroean Lukman , Ko Wai Wai 
Published: September 2019

Purpose
The purpose of this paper is to investigate the influence of supply chain (SC) justice practices in shared value-supplier delivery performance relationship and the contingent role of trust in SC ecosystem operation.

Design/methodology/approach
The authors collect and analyze dyadic survey data from a marina resort SC ecosystem in Indonesia.

Findings
The results suggest the differential moderating effects of two types of perceived SC justice – perceived procedural justice and perceived interactional justice – on the relationship between shared value and supplier delivery performance. More specifically, we find that perceived procedural justice strengthens the shared value-supplier delivery performance relationship, but that perceived interactional justice weakens such a relationship. Furthermore, the findings demonstrate a positive three-way interaction effect between shared value, perceived SC justice and trust on supplier delivery performance.

Originality/value
The study is the first to introduce the role of SC justice practices in SC ecosystem operation. The authors examine how shared value interacts with perceived SC justice and trust in order to determine supplier delivery performance.
A review of the empirical research on teacher leadership (2003–2017)
Authors: Nguyen Dong , Harris Alma , Ng David 
Published: September 2019

Purpose
The purpose of this paper is to outline key findings from a contemporary review of the international empirical literature focused upon teacher leadership. It synthesises what is currently known about the nature, practice, conditions and impact of teacher leadership and to outline patterns in the contemporary empirical research base.

Design/methodology/approach
This review is based on an analysis of 150 empirical articles published in Scopus/SSCI-indexed journals between January 2003 and December 2017.

Findings
The paper draws upon this contemporary knowledge base to explore: contextual and methodological patterns of teacher leadership research; definitions of teacher leadership; and evidence on the enactment of teacher leadership, factors influencing teacher leadership and impacts of teacher leadership.

Originality/value
This paper highlights the progress and issues of the empirical research on teacher leadership since 2003 and identifies gaps in the knowledge base as well as areas for future scholarly enquiry.
Mechanical behavior of an additively manufactured poly-carbonate specimen: tensile, flexural and mode I fracture properties
Authors: Sedighi Iman , Ayatollahi Majid R. , Bahrami Bahador , Pérez-Martínez Marco A. , Garcia-Granada Andres A. 
Published: September 2019

PurposeThe purpose of this paper is to investigate the effect of layer orientation on the tensile, flexural and fracture behavior of additively manufactured (AM) polycarbonate (PC) produced using fused deposition modeling (FDM).Design/methodology/approachAn experimental approach is undertaken and a total number of 48 tests are conducted. Two types of tensile specimens are used and their mechanical behavior and fracture surfaces are studied. Also, circular parts with different layer orientations are printed and two semi-circular bending (SCB) samples are extracted from each part. Finally, the results of samples with different build directions are compared to one another to better understand the mechanical behavior of additively manufactured PC.FindingsThe results demonstrate anisotropy in the tensile, flexural and fracture behavior of the additively manufactured PC parts with the latter being less anisotropic compared to the first two. It is also demonstrated that the anisotropy of the elastic modulus is small and can be neglected. Tensile strength ranges from 40 MPa to 53 MPa. At the end, mode I fracture toughness prediction curves are provided for different directions of the FDM samples. Fracture toughness ranges from 1.93 to 2.37 MPa.mm1/2.Originality/valueThe SCB specimen, a very suitable geometry for characterizing anisotropic materials, was used to characterize FDM parts for the first time. Also, the fracture properties of the AM PC have not been studied by the researchers in the past. Therefore, fracture toughness prediction curves are presented for this anisotropic material. These curves can be very suitable for designing parts that are going to be produced by 3D printing. Moreover, the effect of the area to perimeter ratio on the tensile properties of the printed parts is investigated.
The role of absorptive capacity within supply chain quality integration
Authors: Alkalha Ziad , Reid Iain , Dehe Benjamin 
Published: September 2019

PurposeThere is a consensus suggesting that the theoretical underpinning associated with supply chain quality management practices remain evolutionary to current thinking. Therefore, this study aims to explore how absorptive capacity (AC) supports supply chain quality integration (SCQI) by building product and process quality within a supply chain (SC).Design/methodology/approachA comparative case study of global pharmaceutical manufacturers in a developing market was undertaken. A two-round qualitative research method was designed to collect data through 54 semi-structured interviews with pharmaceutical managers and senior managers.FindingsThe results demonstrate that AC is essential to the development of SCQI because of its ability to use valuable strategic and operational knowledge, which is important when improving consistent internal product and process quality, along with establishing a robust SC design. The authors found that AC enables companies to design their quality and continuously improve their products and processes among their SC members.Research limitations/implicationsThe authors acknowledge that these sets of findings are difficult to generalise to other sectors, however, the authors are confident that they can be extrapolated to other companies in the pharmaceutical industry.Practical implicationsThe study develops a framework to support practitioners and decision makers to leverage their AC towards facilitating their SCQI practices.Originality/valueThis study explains the role of the AC process in relation to SCQI practices, in the context of the pharmaceutical SC. The study profiles the characteristics of dynamic capabilities to increase the companies’ competencies, processes and resources.
Guidelines for effective intercultural business negotiations
Authors: Usunier Jean-Claude 
Published: September 2019

Purpose
For managers and senior executives who find themselves negotiating with international partners who differ in terms of culture, communication style, time orientation, as well as personal and professional backgrounds, understanding the complex range of factors that impact intercultural business negotiations (ICBN) for short – is a fundamentally important skill.

Design/methodology/approach
This paper is based on an organised review of literature on culture and business negotiations in Usunier (2019), systematically examining the interface of culture with dispositional (e.g. negotiator’s gender) and situational variable (e.g. type of contract, one-shot versus repeated deals).

Findings
Empathy is not all, culture overlaps and interacts with other key negotiation variables. The paper derives a set of guidelines for effective ICBN.

Originality/value
Many approaches to ICBN emphasise culture as a stand-alone variable. The approach helps to avoid naïve behaviour and proposes a framework for linking cultural aspects to other major situational and dispositional variables in the ICBN process.
Alien species spreading via biofouling on recreational vessels in the Mediterranean Sea
Authors: Ulman Aylin , Ferrario Jasmine , Forcada Aitor , Seebens Hanno , Arvanitidis Christos , Occhipinti‐Ambrogi Anna , Marchini Agnese 
Published: September 2019

AbstractDespite the Mediterranean being both a hotspot for recreational boating and for non‐indigenous species (NIS), no data currently exists on the recreational boating sector's contribution to the spread of NIS in this Sea.To improve the basis for management decisions, a wide‐scale sampling study on the biofouling communities of recreational vessels and marinas was undertaken. Specifically, we surveyed over 600 boat owners and sampled the same boat hulls for NIS in 25 marinas across the Mediterranean, from France to Cyprus, to determine which factors (i.e. boat characteristics, travel behaviour, home marina) are associated with higher NIS richness on boat hulls.Among the surveyed boats, we found recreational vessels to travel considerably, averaging 67 travel days and 7.5 visited marinas per annum. This results in a high potential for spreading NIS, especially as 71% of sampled vessels host at least one (and up to 11) NIS. Boats with high NIS richness strongly correlate with home marinas with high NIS richness. Over half of the vessels were carriers of NIS which were not yet present in the marinas they were visiting. The presence of biofouling in niche areas of the hull (i.e. in the cavities and metallic parts) emerges as the best predictor for NIS richness on boats, along with longer times since their last cleaning and antifouling applications. Interestingly, colonization of NIS occurred rapidly, even on boats that had recently had their hulls cleaned professionally.Synthesis and applications. We demonstrate that recreational boating has a very high capacity for the spread of non‐indigenous species (NIS) in the Mediterranean, due to both high NIS richness on boats and extensive travel. To counteract the spread of NIS, routine monitoring for new NIS needs to be established for both marinas and vessels, along with frequent pontoon cleaning. Additionally, policy should require preliminary screenings for incoming vessels from new countries, especially those emanating from high‐risk marinas. The niche areas of the boat hulls should be checked first for biofouling, which was the best predictor for NIS richness since they often go overlooked with in‐water cleanings are rarely have antifouling applied to them.
White Parents, Black Care: Entanglements of Race and Kinship in American Transracial Adoption
Authors: Mariner Kathryn A. 
Published: September 2019

ABSTRACTIn Chicago, transracial adoption often unites white parents and Black children who are visibly different from one another and share no biogenetic connection. Although anthropologists in the United States have long understood that kinship is not biological, the enduring cultural grounding of Blackness in ancestry and the body repeatedly upsets a solely social understanding of kinship. Within the context of transracial adoption, contested claims to kinship are mediated through the racialized body of the child, namely, through hair and its care. Based on ethnographic fieldwork with adoptive parents, social workers, and hair‐care professionals in and around Chicago between 2009 and 2016, this article examines two related forms of Black care centered on the child's hair: (1) a Black gaze directed toward transracially adopted children, and (2) the outsourcing of Black hair‐care and hair‐care training to Black women. By asserting racial connection, these practices trouble adoptive claims to kinship. Although transracial adoption appears to challenge biological notions of kinship, it remains foundationally structured by them due to embodied understandings of race. [adoption, kinship, race, care, hair]
Selectively bred oysters can alter their biomineralization pathways, promoting resilience to environmental acidification
Authors: Fitzer Susan C. , McGill Rona A. R. , Torres Gabarda Sergio , Hughes Brian , Dove Michael , O'Connor Wayne , Byrne Maria 
Published: September 2019

AbstractCommercial shellfish aquaculture is vulnerable to the impacts of ocean acidification driven by increasing carbon dioxide (CO2) absorption by the ocean as well as to coastal acidification driven by land run off and rising sea level. These drivers of environmental acidification have deleterious effects on biomineralization. We investigated shell biomineralization of selectively bred and wild‐type families of the Sydney rock oyster Saccostrea glomerata in a study of oysters being farmed in estuaries at aquaculture leases differing in environmental acidification. The contrasting estuarine pH regimes enabled us to determine the mechanisms of shell growth and the vulnerability of this species to contemporary environmental acidification. Determination of the source of carbon, the mechanism of carbon uptake and use of carbon in biomineral formation are key to understanding the vulnerability of shellfish aquaculture to contemporary and future environmental acidification. We, therefore, characterized the crystallography and carbon uptake in the shells of S. glomerata, resident in habitats subjected to coastal acidification, using high‐resolution electron backscatter diffraction and carbon isotope analyses (as δ13C). We show that oyster families selectively bred for fast growth and families selected for disease resistance can alter their mechanisms of calcite crystal biomineralization, promoting resilience to acidification. The responses of S. glomerata to acidification in their estuarine habitat provide key insights into mechanisms of mollusc shell growth under future climate change conditions. Importantly, we show that selective breeding in oysters is likely to be an important global mitigation strategy for sustainable shellfish aquaculture to withstand future climate‐driven change to habitat acidification.