bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ground Deformations in the Corinth Rift, Greece, Investigated Through the Means of SAR Multitemporal Interferometry
Authors: Elias P. , Briole P. 
Published: November 2018

AbstractThe Corinth Rift is one of the narrowest and fastest extending continental regions worldwide and has one of the highest seismicity rates in the Euro‐Mediterranean region. At its western termination, several active faults are located beneath the city of Patras and the surrounding area, a region of major socioeconomic importance for Greece. Displacement rates for the period 2002–2010 obtained from ascending and descending ASAR/ENVISAT multitemporal interferometry are combined with Global Positioning System measurements from permanent and campaign stations to produce a map of vertical and east‐west ground velocities. Cross sections are produced in order to quantify the deformation rates with higher precision. In the vertical, the motion combines tectonic deformation, urban subsidence, and subsidence due to deltaic sediments compaction. In the city of Patras and through the gulf of Patras, the northern continuation of the 2008 Movri earthquake fault is connected to the oblique transform zone of Rio. Further east, our observations suggest the existence of postseismic deformation at Aigion in the 15 years following the Mw = 6.2, 15 June 1995 Aigion earthquake. The inferred deforming zone, assuming a simple slow slipping model, is located at the western end of the 1995 fault, with radius ~3.5 km, centroid depth ~4 km, and cumulated postseismic moment representing 28% of the coseismic. Alluvial fan deltas subside due to their compaction with a gradient that increases toward the shore. Several of those deltas are located in the hanging‐wall of active faults.
The Cathles Parameter (Ct): A Geodynamic Definition of the Asthenosphere and Implications for the Nature of Plate Tectonics
Authors: Richards Mark A. , Lenardic Adrian 
Published: November 2018

AbstractA weak asthenosphere, or low‐viscosity zone (LVZ), underlying Earth's lithosphere has played an important role in interpreting isostasy, postglacial rebound (PGR), and the seismic LVZ, as well as proposed mechanisms for continental drift, plate tectonics, and postseismic relaxation. Consideration of the resolving power of PGR, postseismic relaxation, and geoid modeling studies suggests a sublithospheric LVZ perhaps ~100–200 km thick with a viscosity contrast of ~100–1,000. Ab initio numerical models of plate‐like boundary layer motions in mantle convection also suggest a key role for the LVZ. Paradoxically, a thinner LVZ with a strong viscosity contrast is most effective in promoting plate‐like surface motions. These numerical results are explained in terms of the reduction in horizontal shear dissipation due to an LVZ, and a simple scaling theory leads to somewhat nonintuitive model predictions. For example, an LVZ causes stress magnification at the base of the lithosphere, enhancing plate boundary formation. Also, flow within the LVZ may be driven by the plates (Couette flow), or pressure‐driven from within the mantle (Poiseuille flow), depending upon the degree to which plates locally inhibit or drive underlying mantle convection. For studies of the long‐wavelength geoid, PGR, and mantle convection, a simple dimensionless parameter controls the effect of the LVZ. This “Cathles parameter” is given by Ct = η*(D/λ)3, where η* is the viscosity contrast, D is the thickness of the LVZ, and λ is the flow wavelength, emphasizing the tightly coupled trade‐off between LVZ thickness and viscosity contrast.
Challenges in the Search for Perchlorate and Other Hydrated Minerals With 2.1‐μm Absorptions on Mars
Authors: Leask E. K. , Ehlmann B. L. , Dundar M. M. , Murchie S. L. , Seelos F. P. 
Published: November 2018

AbstractA previously unidentified artifact has been found in Compact Reconnaissance Imaging Spectrometer for Mars targeted I/F data. It exists in a small fraction (<0.05%) of pixels within 90% of images investigated and occurs in regions of high spectral/spatial variance. This artifact mimics real mineral absorptions in width and depth and occurs most often at 1.9 and 2.1 μm, thus interfering in the search for some mineral phases, including alunite, kieserite, serpentine, and perchlorate. A filtering step in the data processing pipeline, between radiance and I/F versions of the data, convolves narrow artifacts (“spikes”) with real atmospheric absorptions in these wavelength regions to create spurious absorption‐like features. The majority of previous orbital detections of alunite, kieserite, and serpentine we investigated can be confirmed using radiance and raw data, but few to none of the perchlorate detections reported in published literature remain robust over the 1.0‐ to 2.65‐μm wavelength range.
Understanding End‐of‐Century Snowpack Changes Over California's Sierra Nevada
Authors: Sun Fengpeng , Berg Neil , Hall Alex , Schwartz Marla , Walton Daniel 
Published: November 2018

AbstractThis study uses dynamical and statistical methods to understand end‐of‐century mean changes to Sierra Nevada snowpack. Dynamical results reveal that middle‐elevation watersheds experience considerably more rain than snow during winter, leading to substantial snowpack declines by spring. Despite some high‐elevation watersheds receiving slightly more snow in January and February, the warming signal still dominates across the wet season and leads to notable declines by springtime. A statistical model is created to mimic dynamical results for 1 April snowpack, allowing for an efficient downscaling of all available general circulation models from the Coupled Model Intercomparison Project phase 5. For all general circulation models and emission scenarios, dramatic 1 April snowpack loss occurs at elevations below 2,500 m, despite increased precipitation in many general circulation models. Only 36% (±12%) of historical 1 April total snow water equivalent volume remains at the century's end under a “business‐as‐usual” emission scenario, with 70% (±12%) remaining under a realistic “mitigation” scenario.
Subduction by Submesoscales
Authors: Canuto V. M. , Cheng Y. , Howard A. M. 
Published: November 2018

AbstractSeveral studies have demonstrated the relevance of submesoscales (SM) to the production of phytoplankton and the ocean absorption of anthropogenic CO2. One variable that thus far has not been fully quantified is the SM‐induced rates of subduction and obduction at the bottom of the mixed layer. In this work, we use an SM parameterization that had been previously assessed to estimate the rates of subduction‐obduction using a coarse resolution stand‐alone ocean code to compute the large‐scale fields. To separate the contributions of baroclinic instabilities from those due to wind stress, we derive an analytic expression for the SM subduction‐obduction rates. Since there are no numerical simulations and/or measurements to assess the results, we compare them to subduction rates due to mesoscales for which an eddy‐permitting southern ocean state estimate is available. An interesting result is that in the Antarctic Circumpolar Current the maximum SM subduction rates are not significantly smaller than those due to mesoscales, but the SM subduction rates exhibit a topology opposite to that of mesoscales: obduction is equatorward and subduction is poleward. Sensitivity studies are presented to explore the dependence of the results on the depth of the SM vertical extent and the SM kinetic energy. On the basis of these results, it is suggested that the SM‐induced subduction should not be neglected because topology and magnitude indicate that mesoscales and submesoscales may add to or subtract from one another.
Snow Hydrology in the Upper Yellow River Basin Under Climate Change: A Land Surface Modeling Perspective
Authors: Liu Wenbin , Wang Lei , Sun Fubao , Li Zehua , Wang Hong , Liu Jiahong , Yang Tao , Zhou Jing , Qi Jia 
Published: November 2018

AbstractSnow has been widely recognized as a crucial component of water resources and is expected to be vulnerable to climate change in cold and mountainous regions. Here we projected climate change impacts on snow hydrology in the upper Yellow River (UYR) basin through a distributed biosphere hydrological model with improved snow physics, forced with Inter‐Sectoral Impact Model Intercomparison Project climate model outputs under two emission scenarios (representative concentration pathways, RCP4.5 and RCP8.5) during the period of 1996–2025. The results indicated that the climate in the UYR basin is turning warmer and wetter. In this context, more precipitation would occur as rain (snow‐to‐precipitation ratio would decrease accordingly). The total runoff generation would increase slightly with increased precipitation. The simulated snow depth and snow water equivalent would decrease by 33% and 19% per 1 °C warming under the RCP4.5. These declined rates would further enlarge under the RCP8.5. Accordingly, the multimodel ensemble mean snowmelt‐to‐runoff ratio decreases by 9% and 7% per 1 °C warming under the two emission scenarios. The projected responses of snow hydrology (e.g., snow depth, snow water equivalent, and snowmelt) to the changing climate in the UYR basin are consistent among different climate models and RCP scenarios, which would provide valuable insights for water resources management, environmental protection, and climate change adaption in high mountainous basins and their downstream regions.
The Impact of Hybrid Usage of a Cumulus Parameterization Scheme on Tropical Convection and Large‐Scale Circulations in a Global Cloud‐System Resolving Model
Authors: Miyakawa Tomoki , Noda Akira T. , Kodama Chihiro 
Published: November 2018

AbstractThe impact of activating a cumulus parameterization scheme in the global nonhydrostatic icosahedral atmospheric model (NICAM) coupled with a one‐dimensional (1‐D) mixed‐layer ocean model is assessed using a cloud‐system‐resolving, 14‐km mesh. The Chikira‐Sugiyama (CS) scheme, which employs an entrainment rate sensitive to the humidity of the environment, can consider congestus clouds in the tropics when used in conventional global climate models. Congestus clouds are underresolved in the default 14‐km mesh NICAM. In the present study, boreal summer NICAM simulations are performed with and without the CS scheme, and several different scheme parameters are evaluated. The results show that the horizontal scale of convection and precipitable water increased in the tropics when using the CS scheme. Model adjustments were apparent at two different timescales: a rapid adjustment within the first week and a slower adjustment at 1 to 2 months. Both effects were magnified in the simulations that employed smaller values for the parameter that defines the fractional of loss of buoyancy‐generated energy in parameterized convection. The upward branch of the Hadley circulation shifted northward, and the Walker circulation was enhanced when the CS scheme was activated. These large‐scale adjustments suggested that increased midtropospheric moisture in the tropics tends to favor larger organized convective activities, which require an abundant supply of moisture, which, in this case, is available to the north of the equatorial West Pacific Ocean.
The spread of low-credibility content by social bots
Authors: Shao Chengcheng , Ciampaglia Giovanni Luca , Varol Onur , Yang Kai-Cheng , Flammini Alessandro , Menczer Filippo 
Published: November 2018

AbstractThe massive spread of digital misinformation has been identified as a major threat to democracies. Communication, cognitive, social, and computer scientists are studying the complex causes for the viral diffusion of misinformation, while online platforms are beginning to deploy countermeasures. Little systematic, data-based evidence has been published to guide these efforts. Here we analyze 14 million messages spreading 400 thousand articles on Twitter during ten months in 2016 and 2017. We find evidence that social bots played a disproportionate role in spreading articles from low-credibility sources. Bots amplify such content in the early spreading moments, before an article goes viral. They also target users with many followers through replies and mentions. Humans are vulnerable to this manipulation, resharing content posted by bots. Successful low-credibility sources are heavily supported by social bots. These results suggest that curbing social bots may be an effective strategy for mitigating the spread of online misinformation.
Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture
Authors: Villahoz Silvia , Yunes-Leites Paula Sofía , Méndez-Barbero Nerea , Urso Katia , Bonzon-Kulichenko Elena , Ortega Sagrario , Nistal J. Francisco , Vazquez Jesus , Offermanns Stefan , Redondo Juan Miguel , Campanero Miguel R. 
Published: November 2018

AbstractAortic intramural hematoma (IMH) can evolve toward reabsorption, dissection or aneurysm. Hypertension is the most common predisposing factor in IMH and aneurysm patients, and the hypertensive mediator angiotensin-II induces both in mice. We have previously shown that constitutive deletion of Rcan1 isoforms prevents Angiotensin II-induced aneurysm in mice. Here we generate mice conditionally lacking each isoform or all isoforms in vascular smooth muscle cells, endothelial cells, or ubiquitously, to determine the contribution to aneurysm development of Rcan1 isoforms in vascular cells. Surprisingly, conditional Rcan1 deletion in either vascular cell-type induces a hypercontractile phenotype and aortic medial layer disorganization, predisposing to hypertension-mediated aortic rupture, IMH, and aneurysm. These processes are blocked by ROCK inhibition. We find that Rcan1 associates with GSK-3β, whose inhibition decreases myosin activation. Our results identify potential therapeutic targets for intervention in IMH and aneurysm and call for caution when interpreting phenotypes of constitutively and inducibly deficient mice.
A diagnosis of the plasma waves responsible for the explosive energy release of substorm onset
Authors: Kalmoni N. M. E. , Rae I. J. , Watt C. E. J. , Murphy K. R. , Samara M. , Michell R. G. , Grubbs G. , Forsyth C. 
Published: November 2018

AbstractDuring geomagnetic substorms, stored magnetic and plasma thermal energies are explosively converted into plasma kinetic energy. This rapid reconfiguration of Earth’s nightside magnetosphere is manifest in the ionosphere as an auroral display that fills the sky. Progress in understanding of how substorms are initiated is hindered by a lack of quantitative analysis of the single consistent feature of onset; the rapid brightening and structuring of the most equatorward arc in the ionosphere. Here, we exploit state-of-the-art auroral measurements to construct an observational dispersion relation of waves during substorm onset. Further, we use kinetic theory of high-beta plasma to demonstrate that the shear Alfven wave dispersion relation bears remarkable similarity to the auroral dispersion relation. In contrast to prevailing theories of substorm initiation, we demonstrate that auroral beads seen during the majority of substorm onsets are likely the signature of kinetic Alfven waves driven unstable in the high-beta magnetotail.
Martian magmatism from plume metasomatized mantle
Authors: Day James M. D. , Tait Kimberly T. , Udry Arya , Moynier Frédéric , Liu Yang , Neal Clive R. 
Published: November 2018

AbstractDirect analysis of the composition of Mars is possible through delivery of meteorites to Earth. Martian meteorites include ∼165 to 2400 Ma shergottites, originating from depleted to enriched mantle sources, and ∼1340 Ma nakhlites and chassignites, formed by low degree partial melting of a depleted mantle source. To date, no unified model has been proposed to explain the petrogenesis of these distinct rock types, despite their importance for understanding the formation and evolution of Mars. Here we report a coherent geochemical dataset for shergottites, nakhlites and chassignites revealing fundamental differences in sources. Shergottites have lower Nb/Y at a given Zr/Y than nakhlites or chassignites, a relationship nearly identical to terrestrial Hawaiian main shield and rejuvenated volcanism. Nakhlite and chassignite compositions are consistent with melting of hydrated and metasomatized depleted mantle lithosphere, whereas shergottite melts originate from deep mantle sources. Generation of martian magmas can be explained by temporally distinct melting episodes within and below dynamically supported and variably metasomatized lithosphere, by long-lived, static mantle plumes.
Samarium(II) folding cascades involving hydrogen atom transfer for the synthesis of complex polycycles
Authors: Plesniak Mateusz P. , Garduño-Castro Monserrat H. , Lenz Philipp , Just-Baringo Xavier , Procter David J. 
Published: November 2018

AbstractThe expedient assembly of complex, natural product-like small molecules can deliver new chemical entities with the potential to interact with biological systems and inspire the development of new drugs and probes for biology. Diversity-oriented synthesis is a particularly attractive strategy for the delivery of complex molecules in which the 3-dimensional architecture varies across the collection. Here we describe a folding cascade approach to complex polycyclic systems bearing multiple stereocentres mediated by reductive single electron transfer (SET) from SmI2. Simple, linear substrates undergo three different folding pathways triggered by reductive SET. Two of the radical cascade pathways involve the activation and functionalization of otherwise inert secondary alkyl and benzylic groups by 1,5-hydrogen atom transfer (HAT). Combination of SmI2, a privileged reagent for cascade reactions, and 1,5-HAT can lead to complexity-generating radical sequences that unlock access to diverse structures not readily accessible by other means.
A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity
Authors: Compte Marta , Harwood Seandean Lykke , Muñoz Ines G. , Navarro Rocio , Zonca Manuela , Perez-Chacon Gema , Erce-Llamazares Ainhoa , Merino Nekane , Tapia-Galisteo Antonio , Cuesta Angel M. , Mikkelsen Kasper , Caleiras Eduardo , Nuñez-Prado Natalia , Aznar M. Angela , Lykkemark Simon , Martínez-Torrecuadrada Jorge , Melero Ignacio , Blanco Francisco J. , Bernardino de la Serna Jorge , Zapata Juan M. , Sanz Laura , Alvarez-Vallina Luis 
Published: November 2018

AbstractThe costimulation of immune cells using first-generation anti-4-1BB monoclonal antibodies (mAbs) has demonstrated anti-tumor activity in human trials. Further clinical development, however, is restricted by significant off-tumor toxicities associated with FcγR interactions. Here, we have designed an Fc-free tumor-targeted 4-1BB-agonistic trimerbody, 1D8N/CEGa1, consisting of three anti-4-1BB single-chain variable fragments and three anti-EGFR single-domain antibodies positioned in an extended hexagonal conformation around the collagen XVIII homotrimerization domain. The1D8N/CEGa1 trimerbody demonstrated high-avidity binding to 4-1BB and EGFR and a potent in vitro costimulatory capacity in the presence of EGFR. The trimerbody rapidly accumulates in EGFR-positive tumors and exhibits anti-tumor activity similar to IgG-based 4-1BB-agonistic mAbs. Importantly, treatment with 1D8N/CEGa1 does not induce systemic inflammatory cytokine production or hepatotoxicity associated with IgG-based 4-1BB agonists. These results implicate FcγR interactions in the 4-1BB-agonist-associated immune abnormalities, and promote the use of the non-canonical antibody presented in this work for safe and effective costimulatory strategies in cancer immunotherapy.
Lattice-contraction triggered synchronous electrochromic actuator
Authors: Li Kerui , Shao Yuanlong , Yan Hongping , Lu Zhi , Griffith Kent J. , Yan Jinhui , Wang Gang , Fan Hongwei , Lu Jingyu , Huang Wei , Bao Bin , Liu Xuelong , Hou Chengyi , Zhang Qinghong , Li Yaogang , Yu Junsheng , Wang Hongzhi 
Published: November 2018

AbstractMaterials with synchronous capabilities of color change and actuation have prospects for application in biomimetic dual-stealth camouflage and artificial intelligence. However, color/shape dual-responsive devices involve stimuli that are difficult to control such as gas, light or magnetism, and the devices show poor coordination. Here, a flexible composite film with electrochromic/actuating (238° bending angle) dual-responsive phenomena, excellent reversibility, high synchronization, and fast response speed (< 5 s) utilizes a single active component, W18O49 nanowires. From in situ synchrotron X-ray diffraction, first principles calculations/numerical simulations, and a series of control experiments, the actuating mechanism for macroscopic deformation is elucidated as pseudocapacitance-based reversible lattice contraction/recovery of W18O49 nanowires (i.e. nanostructure change at the atomic level) during lithium ion intercalation/de-intercalation. In addition, we demonstrate the W18O49 nanowires in a solid-state ionic polymer-metal composite actuator that operates stably in air with a significant pseudocapacitive actuation.
Molecular insights into genome-wide association studies of chronic kidney disease-defining traits
Authors: Xu Xiaoguang , Eales James M. , Akbarov Artur , Guo Hui , Becker Lorenz , Talavera David , Ashraf Fehzan , Nawaz Jabran , Pramanik Sanjeev , Bowes John , Jiang Xiao , Dormer John , Denniff Matthew , Antczak Andrzej , Szulinska Monika , Wise Ingrid , Prestes Priscilla R. , Glyda Maciej , Bogdanski Pawel , Zukowska-Szczechowska Ewa , Berzuini Carlo , Woolf Adrian S. , Samani Nilesh J. , Charchar Fadi J. , Tomaszewski Maciej 
Published: November 2018

AbstractGenome-wide association studies (GWAS) have identified >100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations remain elusive. Using 280 kidney transcriptomes and 9958 gene expression profiles from 44 non-renal tissues we uncover gene expression partners (eGenes) for 88.9% of CKD-dt GWAS loci. Through epigenomic chromatin segmentation analysis and variant effect prediction we annotate functional consequences to 74% of these loci. Our colocalisation analysis and Mendelian randomisation in >130,000 subjects demonstrate causal effects of three eGenes (NAT8B, CASP9 and MUC1) on estimated glomerular filtration rate. We identify a common alternative splice variant in MUC1 (a gene responsible for rare Mendelian form of kidney disease) and observe increased renal expression of a specific MUC1 mRNA isoform as a plausible molecular mechanism of the GWAS association signal. These data highlight the variants and genes underpinning the associations uncovered in GWAS of CKD-dt.