bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of a weight bearing ankle equinus value in older adults with diabetes
Authors: Searle MOsteo A. , Spink M. J. , Chuter V. H. 
Published: November 2018

AbstractBackgroundAccurate measurement of ankle joint dorsiflexion is clinically important as a restriction has been linked to many foot and ankle pathologies, as well as increased ulcer risk and delayed ulcer healing in people with diabetes. Use of the reliable weight bearing (WB) Lunge test is limited as normal and restricted ranges for WB ankle joint dorsiflexion are not identified. Additionally the extent of WB dorsiflexion restriction that results in clinically adverse outcomes is unclear. Therefore the aim of this investigation is to validate a proposed weight bearing equinus value (dorsiflexion < 30°) in unimpaired cohorts, and secondly to investigate any clinical effects this degree of ankle dorsiflexion restriction has on forefoot plantar pressure variables in older adults with diabetes.MethodsAnkle dorsiflexion was measured using a Lunge test with the knee extended in young adults without diabetes (YA) and older adults with diabetes (DA). In‐shoe and barefoot plantar pressure was recorded for the DA group. Spearman's correlation was calculated to determine any association between the presence of ankle equinus and plantar pressure variables in the DA group. DA group differences in people with and without an equinus were examined.ResultsA weight bearing equinus of < 30°, assessed in a lunge using an inclinometer placed on the anterior tibia, falls within the restricted range in young unimpaired cohorts. In the DA group this degree of ankle restriction had a fair and significant association with elevated barefoot forefoot peak pressure (r = 0.274, p = 0.005) and pressure‐time integrals (r = 0.321, p = .001). The DA equinus group had significantly higher barefoot peak pressure (mean kPa (SD): 787.1 (246.7) vs 652.0 (304.5), p = 0.025) and pressure‐time integrals (mean kPa (SD): 97.8 (41.6) vs 80.4 (30.5), p = 0.017) than the DA non equinus group.ConclusionsWe support a preliminary weight bearing ankle equinus value of < 30°. This value represents a restricted range in young adults and is correlated with increased forefoot plantar pressure variables in older adults with diabetes. Mean population weight bearing ankle dorsiflexion data presented here for older adults with diabetes, will allow use of the more functional Lunge test with knee extended in research and clinical practice.
Leveraging Human Genetics to Guide Cancer Drug Development
Authors: Kinnersley Ben , Sud Amit , Coker Elizabeth A. , Tym Joseph E. , Di Micco Patrizio , Al-Lazikani Bissan , Houlston Richard S. 
Published: November 2018

Purpose The high attrition rate of cancer drug development programs is a barrier to realizing the promise of precision oncology. We have examined whether the genetic insights from genome-wide association studies of cancer can guide drug development and repurposing in oncology. Materials and Methods Across 37 cancers, we identified 955 genetic risk variants from the National Human Genome Research Institute-European Bioinformatics Institute genome-wide association study catalog. We linked these variants to target genes using strategies that were based on linkage disequilibrium, DNA three-dimensional structure, and integration of predicted gene function and expression. With the use of the Informa Pharmaprojects database, we identified genes that are targets of unique drugs and assessed the level of enrichment that would be afforded by incorporation of genetic information in preclinical and phase II studies. For targets not under development, we implemented machine learning approaches to assess druggability. Results For all preclinical targets incorporating genetic information, a 2.00-fold enrichment of a drug being successfully approved could be achieved (95% CI, 1.14- to 3.48-fold; P = .02). For phase II targets, a 2.75-fold enrichment could be achieved (95% CI, 1.42- to 5.35-fold; P < .001). Application of genetic information suggests potential repurposing of 15 approved nononcology drugs. Conclusion The findings illustrate the value of using insights from the genetics of inherited cancer susceptibility discovery projects as part of a data-driven strategy to inform drug discovery. Support for cancer germline genetic information for prospective targets is available online from the Institute of Cancer Research.
Gli2 modulates cell cycle re-entry through autophagy-mediated regulation of the length of primary cilia
Authors: Hsiao Ching-Ju , Chang Chia-Hsiang , Ibrahim Ridwan Babatunde , Lin I-Hsuan , Wang Chun-Hung , Wang Won-Jing , Tsai Jin-Wu 
Published: November 2018

ABSTRACT
The primary cilium is a tiny cell protrusion known to transduce key extracellular signals, including those of the sonic hedgehog pathway, which activates Gli transcription factors for various cellular functions. To understand the significance of the Gli2 transcription factor in fibroblasts, we establish a Gli2-knockout NIH3T3 cell line by CRISPR/Cas9 technology. Surprisingly, NIH3T3 fibroblasts lacking Gli2 expression through gene knockout or RNA interference possess longer primary cilia after stimulation of ciliogenesis by serum starvation. This lengthening of primary cilia is associated with enhanced autophagy-mediated Ofd1 degradation, and can be reversed by pharmacological and genetic inhibition of autophagy. Meanwhile, flow cytometry reveals that Gli2−/− NIH3T3 fibroblasts exhibit a delay in cell cycle re-entry after serum re-stimulation. Ablation of their primary cilia through Kif3a knockdown rescues the delay in cell cycle re-entry. These results suggest that Gli2 plays an unexpected role in cell cycle re-entry through an autophagy-mediated regulation on ciliary length in fibroblasts.
Association of thrombocytopenia with splenomegaly in malaria patients in East Kalimantan: A cross-sectional, retrospective study
Authors: Siagian Loly R.D. , Lumbantoruan Vera M. , Hasanah Nurul , Sihotang Fransiska A. , Gunawan Carta 
Published: November 2018

Background: Malaria still presents as a major health problem in Indonesia and specifically in East Kalimantan. One common finding in malaria is thrombocytopenia, the mechanism of which is still unclear. Several studies have suggested some mechanisms, one of which is splenomegaly. This study aimed to discover the association between thrombocytopenia and splenomegaly of malaria patients in East Kalimantan. Methods: This study was a descriptive retrospective study with clinical and laboratory data obtained from the medical records of malaria patients in four major public hospitals from January 2015 to July 2018. The association between thrombocytopenia with splenomegaly was analysed using Chi-Square test. Results: A total of 215 patients were included; 189 male (87.9%) and 26 female (12.1%). The most common aetiology were Plasmodium vivax (43.2%), P. falciparum (42.8%), and mixed infection (P. falciparum and P. vivax) (4.6%). The distribution of thrombocyte count were normal in 28 patients (13%) and decreased in 187 patients (87%). Among patients with thrombocytopenia, the percentage of mild, moderate and severe thrombocytopenia was 18.2%, 43.8% and 33%, respectively. Splenomegaly was found in only 11 patients (5.1%). We found no association between thrombocytopenia with splenomegaly (p=0.61). Conclusions: We conclude that thrombocytopenia is not associated with splenomegaly in these malaria patients.
Wear performance of retrieved metal-on-metal Pinnacle hip arthroplasties implanted before and after 2007
Authors: Bergiers S. , Hothi H. S. , Henckel J. , Eskelinen A. , Skinner J. , Hart A. 
Published: November 2018

Objectives Previous studies have suggested that metal-on-metal (MoM) Pinnacle (DePuy Synthes, Warsaw, Indiana) hip arthroplasties implanted after 2006 exhibit higher failure rates. This was attributed to the production of implants with reduced diametrical clearances between their bearing surfaces, which, it was speculated, were outside manufacturing tolerances. This study aimed to better understand the performance of Pinnacle Systems manufactured before and after this event. Methods A total of 92 retrieved MoM Pinnacle hips were analyzed, of which 45 were implanted before 2007, and 47 from 2007 onwards. The ‘pre-2007’ group contained 45 implants retrieved from 21 male and 24 female patients, with a median age of 61.3 years (interquartile range (IQR) 57.1 to 65.5); the ‘2007 onwards’ group contained 47 implants retrieved from 19 male and 28 female patients, with a median age of 61.8 years (IQR 58.5 to 67.8). The volume of material lost from their bearing and taper surfaces was measured using coordinate and roundness measuring machines. These outcomes were then compared statistically using linear regression models, adjusting for potentially confounding factors. Results There was no significant difference between the taper and bearing wear rates of the ‘pre-2007’ and ‘2007 onwards’ groups (p = 0.67 and p = 0.39, respectively). Pinnacles implanted from 2007 onwards were revised after a mean time of 50 months, which was significantly earlier than the ‘pre-2007’ hips (96 months) (p < 0.001). A reduction in the time to revision was present year on year from 2003 to 2011. Conclusion We found no difference in the wear rate of these implants based on the year of implantation. The ‘pre-2007’ hips had a two-fold greater time to revision than those implanted after 2007; this may be due to the increased surveillance of MoM hips following UK regulatory advice and several high-profile failures. Interestingly, we observed a decreasing trend in the mean time to revision every year from 2003 onwards. Cite this article: S. Bergiers, H. S. Hothi, J. Henckel, A. Eskelinen, J. Skinner, A. Hart. Wear performance of retrieved metal-on-metal Pinnacle hip arthroplasties implanted before and after 2007. Bone Joint Res 2018;7:595–600. DOI: 10.1302/2046-3758.711.BJR-2018-0143.R1.
Development and Validation of Apolipoprotein AI-Associated Lipoprotein Proteome Panel for the Prediction of Cholesterol Efflux Capacity and Coronary Artery Disease
Authors: Jin Zhicheng , Collier Timothy S , Dai Darlene L Y , Chen Virginia , Hollander Zsuzsanna , Ng Raymond T , McManus Bruce M , Balshaw Robert , Apostolidou Sophia , Penn Marc S , Bystrom Cory 
Published: November 2018

Abstract

BACKGROUND
Cholesterol efflux capacity (CEC) is a measure of HDL function that, in cell-based studies, has demonstrated an inverse association with cardiovascular disease. The cell-based measure of CEC is complex and low-throughput. We hypothesized that assessment of the lipoprotein proteome would allow for precise, high-throughput CEC prediction.

METHODS
After isolating lipoprotein particles from serum, we used LC-MS/MS to quantify 21 lipoprotein-associated proteins. A bioinformatic pipeline was used to identify proteins with univariate correlation to cell-based CEC measurements and generate a multivariate algorithm for CEC prediction (pCE). Using logistic regression, protein coefficients in the pCE model were reweighted to yield a new algorithm predicting coronary artery disease (pCAD).

RESULTS
Discovery using targeted LC-MS/MS analysis of 105 training and test samples yielded a pCE model comprising 5 proteins (Spearman r = 0.86). Evaluation of pCE in a case–control study of 231 specimens from healthy individuals and patients with coronary artery disease revealed lower pCE in cases (P = 0.03). Derived within this same study, the pCAD model significantly improved classification (P &lt; 0.0001). Following analytical validation of the multiplexed proteomic method, we conducted a case–control study of myocardial infarction in 137 postmenopausal women that confirmed significant separation of specimen cohorts in both the pCE (P = 0.015) and pCAD (P = 0.001) models.

CONCLUSIONS
Development of a proteomic pCE provides a reproducible high-throughput alternative to traditional cell-based CEC assays. The pCAD model improves stratification of case and control cohorts and, with further studies to establish clinical validity, presents a new opportunity for the assessment of cardiovascular health.
(In)visible ink: Outsiders at the Yaji, the ink installations of Bingyi and Tao Aimin
Authors: Guest Luise 
Published: November 2018

Abstract
The yaji in Imperial China was an ‘elegant gathering’ of scholars who met to play chess, listen to music, and appreciate ink painting and calligraphy. They were generally all-male affairs, often taking place in a walled garden. Recently it has been argued that such forms of semi-private contemplation are appropriate models for exhibiting Chinese contemporary art. This article has two connected parts: the first examines how two women artists, Tao Aimin and Bingyi, ‘outsiders’ to the yaji garden gathering as it was traditionally constructed, subvert (yet also honour) important Chinese traditions. They challenge a gendered historical narrative by means of a reinvigorated and performative ink language, negotiating literal and figurative ‘inside’ and ‘outside’ spaces. Positioned as reconfiguring space in a way that challenges binaries of inside/outside, they interrogate the literati tradition that functioned as an expression of class and gender. Two works in particular exemplify their practice: Bingyi’s Époché, a 2014 performance in which she dropped 500 kilograms of ink/oil ‘missiles’ from a helicopter over the airfield at Shenzhen Bao’an Airport, and Tao Aimin’s 2008 The Secret Language of Women, an installation of bound books printed from rural women’s washboards employing the ancient Nüshu script invented by rural women. The second part of the article critically examines contemporary iterations of the yaji as a model for the exhibition of contemporary art. The term yaji is thus used in two ways in this article: as a metaphor to reflect on the absence of women artists in the reinvented literati ink tradition, and in a critical examination of its real-world manifestations in several recent exhibitions. In this context, the works of Tao Aimin and Bingyi occupy a complicated liminal space: they position themselves at times inside feminist discourse and at other times disavow a connection; they occupy a marginal space within dominant contemporary art world discourses and historically masculine discourses around calligraphy and the yaji, yet ‘inside’ the ink tradition. This article was developed from a paper presented at the Annual Conference of the Centre for Chinese Visual Art, School of Art, Birmingham City University, 13 October 2017.
Village transformed: Jin Le and community development through contemporary art
Authors: Wang Meiqin 
Published: November 2018

Abstract
Drawing upon field research, this article examines the work of artist Jin Le who strives to engage his fellow villagers from the remote rural village Shijiezi in light of the growing desire among the contemporary Chinese art circles to seek alternative spaces for artistic production and to make art relevant to community development. Increasingly stricken by the gap between metropolises such as Beijing where he was based and the countryside such as Shijiezi where he grew up, Jin left Beijing in 2005 and has since endeavoured to introduce art as a stimuli for changes to his poverty-laden home village in both materialistic and cultural terms. His work includes making site-specific sculpture and installation works to enrich the public space in the village, taking villagers to participate in art-related events in the cities, inviting artists and other professionals to visit and interact with villagers, initiating projects for collaborations between art professionals and villagers, and facilitating the implementation of these collaborations, among others. Jin’s election to be the village head in 2008 by the villagers and their agreement to offer their private homes as ready-made exhibiting spaces so Shijiezi Museum could be found in 2009 testify to a certain level of efficacy of Jin’s socially engaged art practice. Building upon local support, Jin and his collaborator Qin Ga, a Beijing-based artist, launched the ambitious Fly Together: Shijiezi Village Art Practice Project in 2015. This one-year long collaborative project facilitates the collaboration of 25 artists and artist collectives and 25 local residents, resulting in many thought-provoking artworks and pragmatic outcomes as well as long-term collaborative relationships. Arguably, Jin’s effort highlights the potential of employing art for intersubjective communications, the growth of transformative relationships, and grassroots-initiated social changes, even at a small-scale and with limited resources.
Inside out: The remaking of home as an institution of critique
Authors: Gu Jiangtao 
Published: November 2018

Abstract
As the issue’s call for papers has rightly discerned, contemporary Chinese art utilized spaces outside of the art institution as the site of production and exhibition since its early developments. From the first Star Group exhibition in 1979 to Song Dong’s site-specific work in the 1990s, avant-garde Chinese artists have experimented with spaces that are parasitic or antithetic to the official spaces of the nation-state. Such practices might have successfully deconstructed the art institution and its symbolic orders in an earlier moment, they are nonetheless prone to the processes of institutionalization and canonization. This is especially true when museums, galleries and academics, together with market players, have claimed such spaces and artists as the place and subject of a new order known as ‘institutional critique’. Departing from this straightforward mode of institutional critique, this article identifies home as a critical space in contemporary Chinese art practices since the late 1990s and early 2000s. The production, exhibition and critique of art in China today. Joining what is known as the ‘third wave’ of institutional critique, this article reclaims what might constitute a new subject of cultural criticism precisely when state-sponsored art institutions are defunded and demolished by neo-liberal governments around the globe. Turning inside out, it reworks the dichotomy of interiority and exteriority as they are articulated by the bourgeois class to return art to that of the marginalized and disfranchised.
Independent spaces to the street: Participatory art in Shanghai
Authors: Chun Julie 
Published: November 2018

Abstract
The culture of accelerated museum building and promotion of contemporary art in Shanghai has created a spill-over effect in the upsurge of independent art spaces and self-organized artistic projects on the streets. Yet, participatory art in China that directly engages the viewers has its own prescriptions for ‘publicness’ that does not readily conform to western concepts of site-specificity or the public sphere. By foregrounding cross-disciplinary methods and years of primary field work, this research is a dedicated and vigilant observation of how a new generation of artists are incorporating the community as an integral aspect of their practice to expand the discourse of contemporary art in Shanghai. This article sets the context by providing a brief art historical evaluation of art outside museums and institutions as they emerged in the West and in China. Then, three contemporary case studies in Shanghai are examined to contend that artistic producers who recognise the shifting identities and needs of the public are interrogating the value and potentiality of socially engaging art to expand the cultural literacy for members of its community.
Development of matzo made of wholemeal rye flour and its implementation in the industry
Authors: Zakupszki Zita Boglárka , Véha Antal , Szabó Balázs P. 
Published: November 2018

In the baking industry, continuous development of products is required because consumers with different nutritional needs are pushing for new requirements for food. Along with the low caloric content, there is growing attention to the functional effects of foods.
The aim of our work is the development of a matzo made of wholemeal rye flour, which helps in healthy nutrition for the customer’s and more economical from production’s point of view. The main aim of the product development in our project is to increase the nutrient content by the raise of mineral and fibre content.
In the first part of our work we performed basic measurements with flours used during product development. We measured the quantity and quality of gluten protein with Glutomatic-Gluten Index System, the activity of amylase enzymes with Falling Number 1400 and we did complex dough monitoring with METEFÉM Valorigraphe FQA 205. In the second part of our project we compare the basic matzo with matzos made of 3 different recipes. Based on results of examinations it can be ascertain that the Sample 2 shows more advantageous values of the fibre content’s and the prime cost’s point of view.
Inmigración, escuela y construcción nacional: algunas notas sobre la República Argentina
Authors: Gutiérrez Xosé Manuel Malheiro 
Published: November 2018

ResumenLa población que forma la Argentina finisecular es un aluvión de culturas, lenguas e influencias ideológicas que la estructura política del nuevo Estado pretende uniformar y consolidar bajo un sentimiento identitario que necesariamente debe empezar por formarse en la escuela. Este trabajo presenta unas notas sobre la tendencia de los diferentes colectivos inmigrantes para mantener y preservar sus señas de identidad en el lugar de destino mediante experiencias educativas propias y en las estrategias del propio Estado por crear instrumentos legislativos que ayuden a construir un sentimiento de pertenencia, inherente a la formación de un nuevo ciudadano en el nuevo tiempo político poscolonial. En ambas vertientes de una misma realidad, la escuela desempeña un papel fundamental.Palabras-clave: Inmigración argentina, educación e ideología, legislación educativa.ResumoA população que forma a o fim de século na Argentina é uma enxurrada de culturas, línguas e influências ideológicas que a estrutura política do novo Estado procura padronizar e consolidar sob um sentimento identitário que necessariamente deve começar pela formação na escola. Este trabalho apresenta algumas anotações sobre a tendência de diferentes grupos de imigrantes em manter e preservar a sua identidade no seu destino através das suas próprias experiências educativas e nas próprias estratégias do Estado para criar instrumentos legislativos que ajudem a construir um sentido de pertença, inerente à formação de um novo cidadão no novo período político pós-colonial. Em ambos os aspectos da mesma realidade, a escola desempenha um papel fundamental.Palavras-chave: Imigração argentina, educação e ideologia, legislação educacional. AbstractThe population which forms Argentina from the turn of the century is a barrage of cultures, languages and ideological influences, that the political structure of the new State aims to standardize and consolidate under a sense of identity, which must necessarily being formed at school. This paper presents some notes on the trend of the different collective immigrants to keep and preserve its hallmarks in the destination by means of own educational experiences and strategies of State and legislative created instruments are built to improve a sense of belonging, inherent in the education of a new citizen in the new post-colonial political time. In both aspects of the same reality, the school plays a key role.Keywords: Argentine immigration, education and ideology, educational legislation.