bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incentive mechanism for import substitution of mining equipment
Authors: Grabski A. A. , Rozhkov A. A. 
Published: November 2024

Background. The current geopolitical and economic situation makes the task of attaining the technological sovereignty of Russia particularly relevant. This also concerns the need to improve the current investment legislation in the country, including in the field of special investment contracts (SPIC). The SPIC is a form of public–private partnership, which should be primarily aimed at overcoming the technological gap and import dependence through the implementation of a phased import substitution and innovative development of the Russian coal industry and domestic mining machine building. Aim. To estimate the possibilities of using SPIC as a mechanism to stimulate investment and technological innovation in the process of import substitution of foreign mining equipment in the context of anti-Russian sanctions. Materials and methods. The research was based on the methods of system analysis, expert evaluation, technological foresight, logical and comparative analysis, economic and statistical processing of information, including its tabular interpretation. The data of coal companies and Rosinformmugol JSC, as well as those retrieved from Internet sources and open-access publications, were used. Results. The level of import dependence of the Russian coal industry on foreign mining equipment was evaluated. The possibility of using SPIC to stimulate investment and technological innovation in the process of import substitution of foreign mining equipment in the context of anti-Russian sanctions was estimated. The most critical positions in terms of dependence on imported mining equipment supplies were identified; proposals were made for possible sites to attract investors through the SPIC mechanism for localization of key technological mining equipment and components. Conclusion. The conducted estimation of the possibility of using incentive mechanisms showed SPIC to be an effective mechanism to stimulate the process of import substitution of mining equipment. It should be noted that the current geopolitical and economic situation makes the task of improving investment legislation, which also covers SPIC regulation, particularly important.
Geological structure, lithological and petrophysical properties of Neft Daşlari deposit: patterns of changes in the reservoir properties of productive strata depending on the depth of their occurrence (northwestern part of the South Caspian depression)
Authors: Gurbanov V. Sh. , Sultanov L. A. , Bryukhovetsky O. S. 
Published: November 2024

Background. In this article, we investigate geological, geophysical, and physical aspects that affect the reservoir capacity of oil, gas, and gas condensate fields in the area of the Neft Daşları deposit. Aim. The aim was to study the lithologic and petrographic features of deep-seated strata, as well as their reservoir properties, and to reveal regularities of their change with depth. Methods and materials. To that end, the parameters of carbonation, porosity, permeability, density, granulometric composition, and longitudinal seismic wave propagation velocities were determined. Rock specimens of the Neft Daşları field were collected from exploration wells. Results. The minimum, average, and maximum limits of the physical properties of rocks were established. The dependence of reservoir properties and other physical factors on the depth of rock occurrence was considered. The results obtained allow us to assume the oil and gas bearing capacity of deep-seated strata along with those already under operation.
Rift basins of the late phanerozoic of Africa: regional patterns and conceptual development aspects
Authors: Usova V. M. 
Published: November 2024

Background. This work substantiates the dependence of the development modes of rift basins of the Late Phanerozoic of Afro-Arabia on the size and age of the Lower crust structures (granulite belts) in which they were laid. The author proposes a model to correlate the rifting process with the centers of evolution and regeneration of the African superplume and the spread of heated superdeep material from these centers through the channels of granulite belts. Aim. To clarify the signs and causes of the final differentiation of rift basins into the tectonic types of incomplete and completed development, as well as the tectonic prerequisites for the migration of rift formation from south to north and from west to east. Materials and methods. The study was based on a review of scientific publications, mainly by foreign authors, on the geology of rift basins and crustal complexes. A comparative analysis of geological and geophysical data related to rift basins of different tectonic types was conducted. Results. The following patterns of rift basin development were identified. (1) The final tectonic differentiation of basins and their sedimentation structures of the African granulite belts along which the basins were laid. (2) Rifting migrated from south to north and from west to east from younger granulite belts to older belts with a distance from the evolution centers of the African superplume. In this regime, the magmatic basins of completed development were replaced by amagmatic basins of both tectonic types. (3) The migration of rifting from the end of the Paleozoic in the south and the Triassic in the west to the Late Cenozoic between Africa and Arabia was accompanied by a reduction in time intervals and an increase in the rate of deflection of the basins created by this process. Conclusion. For the first time in Afro-Arabia, the spatial and temporal dependence of rifting on the size and age of the pan-African granulite belts, along which it occurred, and their location relative to the centers of the African superplume was substantiated.
Deposits and occurrences of turquoise and variscite in the Republic of Tajikistan
Authors: Litvinenko A. K. , Vosihov Sh. T. 
Published: November 2024

Background. Turquoise is known to occur in Northern Tajikistan, while variscite is found in Central Tajikistan. Turquoise mineralization is represented by Biryuzakan deposit and four occurrences: Biryuzasay, Shorbulak, Karamazar, Kyzyltash, which are located in the center of the largest mining district Karamazar, on the southern slope of the Qurama Mountains. The turquoise occurrences of Samarkandek and Isfara are situated in the northern branches of the Turkestan Range. Variscite mineralization is located in Central Tajikistan, on the northern slope of the Zarafshan Range, in the upper reaches of the Shing River, on its left side, in the area of a small gold-antimony deposit Chorraga and in the area of a large deposit of Jijikrut. Formation of turquoise and variscite has many common features, thereby allowing them to be considered together as hydrothermal-metasomatic minerals. Aim. To summarize geological materials, taking into account new data obtained regarding turquoise and variscite in the territory of the Republic of Tajikistan, and to analyze the processes of their formation. The study focuses on the Biryuzakan deposit and six occurrences of turquoise as well as two occurrences of variscite. Materials and methods. Rock samples were collected at the Biryuzakan and Chorraga deposits in 2022—2023. Photographic documentation of mine workings and a major regional fault — Biryuzovy Fault — was conducted. A tectonic map of turquoise and variscite occurrences was compiled using literature data. Cartographic, structural, and mineralogical methods were employed for this purpose. Results. For the first time, the study introduced a geological summary of all known deposits and occurrences of turquoise and variscite in the territory of the Republic of Tajikistan and a tectonic map of their location. A new, hydrothermal-metasomatic formation mechanism is proposed, whereinthe substances for turquoise and variscite (copper, aluminum, and phosphorus) were sourced from host volcanic and siliceous rocks through a lateral-secretion process. Conclusion. The proposed hypothesis regarding the formation of turquoise and variscite serves as an alternative to existing views shared by many prominent specialists in the field of gemstone geology.
OPTIMASI PRODUK USPPS BMT KOIM MAWADDAH PUSAT DI ERA DIGITAL
Authors: Bahri Mat , Kholiq Abdul 
Published: November 2024

BMT Koim Mawaddah Pusat menjadi koperasi yang mulai mengikuti perkembangan era digital yaitu memanfaatkan teknologi informasi melalui pembaharuan sistem layanan digital yang bertujuan untuk mempermudah anggota mendapatkan informasi dan bertransaksi keuangan.Penelitian ini menggunakan jenis penelitian kualitatif bersifat deskriptif. Data yang didapatkan dari penelitian ini merupakan hasil wawancara mendalam penulis dengan Branch Manajer dan Anggota USPPS BMT Koim Mawaddah Pusat, selain itu data pendukung lainnya berupa hasil observasi, brosur, website, profil perusahaan dan struktur organisasi. Hasil dari penelitian ini menunjukan bahwa optimasi produk yang dilakukan oleh USPPS BMT Koim Mawaddah di era digital yaitu dengan cara menciptakan aplikasi yang menunjang kemudahan anggota dalam bertransaksi menggunakan produk-produk yang sudah tercover pada aplikasi. Terdapat enam beranda dalam aplikasi yang menunjang kebutuhan anggota yaitu Info Rekening (Check saldo dan History), QR-Code (Transfer atau yang lain tinggal QR-Code), Transaksi (Transfer, Pembayaran atau yang lain), Top Up E-Money (Top up Gopay dan OVO), Pembelian (Mau beli Pulsa) dan Transfer sesama. Aplikasi dinilai sangat efektif dan efisien karena anggota terbantu dalam melakukan transaksi keuangan melalui aplikasi milik USPPS BMT Koim Mawaddah. Efektivitas aplikasi yang dimiliki USPPS BMT Koim Mawaddah diantaranya memudahkan anggota dalam pengecekan informasi saldo, transfer antar anggota dan bank umum, pembelian pulsa, listrik, pengisian dompet digital dan lain-lain.
Sustainable Supply Chain Management in the South African Manufacturing Industry
Authors: Anathi Sokhetye 
Published: November 2024

This paper explores sustainable practices in the South African manufacturing industry, with a focus on green marketing and ethical consumerism. It outlines these phrases and their importance in developing sustainable and socially responsible supply chains. The literature study investigates how green marketing focuses on eco-friendly products and consumer perceptions, whereas ethical consumerism emphasizes fair labour practices and ethical sourcing. This paper adopts literature, drawing exclusively from primary sources such as academic journals and publications accessible through databases like Web of Science. The focus is on synthesizing insights from scholarly articles, research papers, and industry reports to examine the interconnections between green marketing and ethical consumerism. The research aims to provide a comprehensive understanding of the current state and implications of green marketing and ethical consumerism in fostering sustainable supply chains within the South African manufacturing sector, solely relying on information derived from scholarly publications. This article delves deeper into the linkages between these theories, emphasizing the need of consumer education, transparency, and industry collaboration. Manufacturers should follow strategic guidelines, such as effective communication and long-term commitment while implementing these practices. The conclusion emphasizes the transformative path to a sustainable future, in which manufacturers play a key role in promoting economic viability as well as beneficial societal and environmental effect.
Pharmacokinetic study of a new 4,5-dihydroisoxazole-5-carboxamide derivative in rats
Authors: Yaichkov I. I. , Korsakov M. K. , Volkhin N. N. , Petukhov S. S. , Tyushina A. N. , Zaykova V. E. , Lasaraynz O. E. 
Published: November 2024

Introduction. 3-(2-butyl-5-chloro-1H-imidazole-4-yl)-N-[4-methoxy-3-(trifluoromethyl)phenyl]-4,5-dihydro-1,2-oxazole-5-carboxamide (R004) is a prospective new molecule for the treatment of rheumatoid arthritis. This compound is at the stage of preclinical research, during which its pharmacokinetics must be studied along with efficacy and safety. In this case, it is necessary to establish the main pharmacokinetic parameters of the drug and its metabolites in blood plasma after a single administration.Aim. Evaluation of linearity of pharmacokinetics and relative bioavailability of 3-(2-butyl-5-chloro-1H-imidazole-4-yl)-N-[4-methoxy-3-(trifluoromethyl)phenyl]-4,5-dihydro-1,2-oxazole-5-carboxamide and its main metabolites in plasma after a single administration of the substance to rats.Materials and methods. Substance R004 was administered to rats once orally at dosages of 10 mg/kg, 20 mg/kg and 40 mg/kg and intraperitoneally at a dosage of 10 mg/kg. The study was carried out using 24 Wistar rats: 6 rats were used for each of the dosage. Blood samples were collected before administration and 30 min, 1 h, 1 h, 30 min, 2 h, 3 h, 4 h, 6 h, 8 h, 10 h, 12 h, 24 h after administration of the drug. The obtained plasma was stabilized with a 250 mM ammonium acetate solution to prevent hydrolysis of R004. Plasma samples were prepared by means proteins precipitation by acetonitrile solution of internal standards. Measurement of the concentration of R004 and its metabolites 3-(2-butyl-5-chloro-1H-imidazole-4-yl)-4,5-dihydro-1,2-oxazole-5-carboxylic acid (M1) and 4-methoxy-3-(trifluoromethyl)aniline (M2) was performed using HPLC-MS/MS. A non-compartment approach was applied for evaluation pharmacokinetic parameters.Results and discussion. The developed bioanalytical method has been fully validated in accordance with the requirements of the EAEU guideline for conducting bioequivalence study and ICH M10 guideline. The analytical range of determination in plasma of R004 was 2–2000 ng/ml, M1 and M2 – 1–1000 ng/ml. The dependence of the parameters Cmax and AUC0–t of the studied compound and its metabolites on the administered dose was linear. Thus, the value of the correlation coefficient of Cmax R004 was 0.9995, and value of the correlation coefficient of AUC0–t was 0.9991. The presence of enterohepatic recirculation R004 has been determined. The relative bioavailability of R004 was 21.26%.Conclusion. The developed method was successfully applied for the pharmacokinetic research. R004 and its metabolites have linear pharmacokinetics in case of oral administration.
Sistem Notifikasi pada Kompor Gas Menggunakan Aplikasi Telegram Berbasis Mikrokotroller
Authors: Dewi Selvi Amalia , Kristyawan Yudi , Kacung Slamet 
Published: November 2024

Kompor gas merupakan alat yang digunakan untuk memasak, yang bisa saja menyebabkan terjadinya kebakaran yang disebabkan banyaknya orang yang sering lupa mematikan kompor dan terkadang orang masih tidak tahu bahwa kompor masih dalam keadaan menyala. Penelitian ini bertujuan untuk memberikan notifikasi pada aplikasi telegram dan mendapatkan alarm suara dari buzzer ketika kompor dalam keadaan menyala. Metode penelitian dalam perancangan sistem ini mengacu pada model sistem deteksi api pada kompor gas dengan alat yang berbasis mikrokontroler ESP32. Pada penelitian ini komponen yang digunakan adalah flame sensor dan buzzer. Hasil pada penelitian ini yang diperoleh adalah sistem dapat mendeteksi kompor dengan mengirimkan pesan notifikasi di aplikasi telegram secara berkala selama 5 menit sekali dan alarm suara pada secara berkala selama 5 menit sekali bahwa kompor sedang menyala. Sistem ini dapat digunakan untuk membantu mendeteksi dan menghindari potensi terjadinya bahaya kebakaran.
Prototype Monitoring Debit Air pada Jaringan Pipa Berbasis Mikrokontroler
Authors: Sari Dhyah Ayu Intan Permata , Prihartono Edi 
Published: November 2024

Air merupakan sumber kehidupan yang sangat penting. Seiring meningkatnya populasi penduduk maka kebutuhan air sehari-hari terus meningkat. Di Indonesia tingkat kebocoran air pada saluran distribusi saat ini meningkat hingga sampai 30% di tiap daerah, dikarenakan dalam penanganan saat ini kurang efisien karena harus ada laporan warga ke petugas[3]. Salah satu cara untuk mengatasi permasalahan tersebut yaitu memanfaatkan teknologi yang dapat Memonitoring jaringan pipa air secara real time sehingga petugas dapat mempercepat dalam penanganan perbaikan akibat kebocoran. Maka pada penelitian dibuat Prototype sistem monitoring debit air pada jaringan pipa dengan memanfaat teknologi Mikrokontroler, sensor Tekanan MPX5700AP [7] , Flowmeter Yf-S201 [6]dan teknologi Internet of Thing (IoT) yang tersistem dalam “ Prototype monitoring debit air pada jaringan pipa berbasis mikrokontroler “. Sistem ini bekerja dengan membaca tekanan dan debit air sebagai data input, dan menampilkan output pada website berupa Notifikasi nilai ( data input) dan Notifikasi lampu sebagai isyarat. Dari hasil uji coba prototype sistem menitoring debit air pada jaringan pipa ini secara system berjalan baik , yaitu system memberikan notifikasi nilai tekanan, debit air dan isyarat lampu . Hasil akhir dari sistem ini diharapkan , petugas dapat memonitoring melalui website dan jika terjadi masalah dengan jaringan pipa petugas bisa mengetahui secara langsung lokasi terjadi kendala serta cepat dalam penangan perbaiakan jaringan air. Sehingga kerugian materil kebocorana air dapat di minimalisir.
Baricitinib as monotherapy and with topical corticosteroids in moderate-to-severe atopic dermatitis: a systematic review and meta-analysis of dose-response
Authors: Almoghayer Ibrahim H. I. , Soomro Abdul Mateen , Dev Shah , Turesh Muskan , Kumar Ateesh , Kumar Ravi , Meghjiani Aashish , Lamiya Mir Syeda , Hassaan Muhammad , Qureshi Rehan , Kumar Vishal , Ashraf Taimoor , Deepak F. N. U. , Siddiq Mohammad Arham , Haseeb Abdul , Kumar Ayush 
Published: November 2024

IntroductionAtopic dermatitis (AD) is a chronic inflammatory skin disorder that affects millions worldwide, presenting challenges in managing symptoms and quality of life. Current treatments include topical corticosteroids (TCS), but novel approaches, such as Janus kinase (JAK) inhibitors, show promise. Baricitinib, a selective JAK1 and JAK2 inhibitor, targets cytokines involved in AD and offers potential benefits beyond traditional therapies.MethodsA systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to evaluate the efficacy and safety of baricitinib in treating moderate-to-severe AD. We followed PRISMA guidelines and assessed data from PubMed, Cochrane Central, ScienceDirect, and ClinicalTrials.gov up to August 2024. The analysis included trials comparing baricitinib to placebo, with or without TCS, evaluating outcomes such as Investigator's Global Assessment (IGA) scores, Eczema Area and Severity Index (EASI) scores, and safety profiles.ResultsSix RCTs involving 2,595 participants met the inclusion criteria. Baricitinib demonstrated significant improvements in IGA scores, EASI scores, Dermatology Life Quality Index (DLQI), and other outcome measures compared to placebo. The efficacy was consistent across different dosages (1 mg, 2 mg, 4 mg) and whether baricitinib was used with or without TCS. Safety analyses revealed a significant increase in treatment-emergent adverse events (TEAEs), particularly with the 2 mg and 4 mg dosages and with TCS.ConclusionBaricitinib, both alone and in combination with TCS, significantly improves symptoms and quality of life in patients with moderate-to-severe AD, with efficacy consistent across dosages. The safety profile is overall acceptable, though a significant increase in TEAEs was observed, particularly with higher dosages and when used with TCS. Ongoing monitoring of TEAEs is recommended, and future trials with longer follow-up periods are suggested to better understand long-term outcomes.
The application of machine learning in inner built environment: scientometric analysis, limitations, and future directions
Authors: Dwiek Samah Al , Bast Safaa Al 
Published: November 2024

IntroductionThis article investigates the revolutionary influence of artificial intelligence (AI) on interior design, with an emphasis on the incorporation of machine learning ML techniques. The advent of AI has resulted in a paradigm change in design methods, prompting a thorough review of research gaps and the potential for ML applications in a variety of areas of interior design.MethodsA systematic review process was implemented to fill these gaps, consisting of an in-depth evaluation of 28 research publications from Scopus databases categorized into eight themes. The investigation sought to address a pair of primary inquiries: what opportunities exist for using ML in interior design conditions, and what challenges limit its effective implementation.ResultThe study discovered a significant gap in the existing literature, demanding a full assessment to highlight challenges in ML implementation and the potential for applied ML development throughout the whole spectrum of interior design.DiscussionThe findings are intended to provide researchers and enthusiasts with an extensive understanding of ML-based gaps in interior design conditions and to provide various solutions for filling these gaps. This understanding may assist in the development of intelligent ML-driven apps, promoting interior contexts that improve user well-being and psychological comfort.
Chromosome alignment and Kif18A action rely on spindle-localized control of Cdk1 activity
Authors: Serpico Angela Flavia , Pisauro Caterina , Trano Asia , Grieco Domenico 
Published: November 2024

IntroductionDuring mitosis, chromosome alignment at the mitotic spindle equator grants correct chromosome segregation and proper nuclei formation in daughter cells. The kinesin 8 family member Kif18A plays a crucial role for chromosome alignment by localizing at the kinetochore-microtubule (K-MT) plus ends to dampen MT dynamics and stabilize K-MT attachments. Kif18A action is directly antagonized by the master mitotic kinase cyclin B-dependent kinase 1 (Cdk1) and is promoted by protein phosphatase 1 (PP1). Since chromosome alignment precedes Cdk1 inactivation by cyclin B proteolysis, it is unclear how Kif18A evades Cdk1 inhibition.MethodsWe analyzed chromosome alignment and Kif18A in mitotic cells upon genetic perturbation of the phosphorylation-dependent inhibitory control of Cdk1 activity by immunofluorescence and cell fractionation experiments.ResultsWe show here that chromosome alignment in human cells relies on a recently identified fraction of Cdk1 that is inhibited by Wee1-dependent phosphorylation in mitosis (i-Cdk1, standing for inhibited/inactive-Cdk1) and that localized at spindle structures where it promotes proper spindle assembly. Indeed, the reduction of i-Cdk1 led to several spindle defects including spindles with misaligned, bipolarly attached chromosomes showing poor Kif18A localization at their K-MT plus ends. Restoring i-Cdk1 reversed both alignment defects and Kif18A localization. In cells with lowered i-Cdk1, expressing a phosphonull Kif18A mutant version at the sites that serve as Cdk1 substrate significantly rescued the alignment defects.DiscussionMechanistically, our evidence suggests that i-Cdk1 and active PP1 facilitated the dephosphorylation and reactivation of spindle-localized Kif18A. Considering the relevance of Kif18A for survival of aneuploid cancer cells and the potential therapeutic targeting of both Kif18A and Wee1, these findings could also be relevant for cancer therapy.