bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Pembelian Merchandise NCT terhadap Pembentukan Perilaku Konsumtif pada Mahasiswa FISIP ULM
Authors: Pramasti Diva Khofiffah Zanuar , Khairussalam  
Published: November 2024

In maintaining their existence, K-Pop groups not only compete through their music but also merchandise that supports the promotion of the music they release. This research aims to understand how rewards, stimulus and positive experiences from purchasing K-Pop merchandise can lead to repeat purchases. In addition, how individuals use social media as a tool to fulfill needs and get satisfaction rewards. Feeling satisfied because they have received rewards and achieved their needs, causes repeated merchandise purchasing behavior. So that it contributes to the formation of consumptive behavior of students seen from the perspective of behavioral exchange theory and Use and Gratification theory. This type of research uses qualitative research with a qualitative descriptive approach method, data collection techniques with observation, interviews, and documentation. The research informants were obtained by purposive sampling technique totaling 10 students who are fans of the NCT group at the Faculty of Social and Political Sciences. The results showed that the purchase of NCT merchandise was driven by several factors, including positive rewards (pleasure and satisfaction), emotional value in merchandise, as entertainment, self-reward, and external stimuli such as the influence of unboxing content or advertising. However, the research also found that the pleasant experience and satisfaction gained from purchasing NCT merchandise, has the potential to encourage consumptive behavior. Especially in terms of excessive financial spending and merchandise purchases that are often not planned, which affects student financial management. This study provides deep insight into the purchase of NCT merchandise, satisfaction obtained, and consumptive behavior.
The effect of differentiation learning on students’ communication and collaboration skills on environmental change materials
Authors: Pradani Fauziyyah Noumi Restu , Mustofa Romy Faisal , Diella Dea 
Published: November 2024

The purpose of this study is to determine the influence of differentiated learning on communication and collaboration skills of tenth-grade high school students at a school in Central Java on the topic of environmental change. The research method used was a Quasi Experiment with a posttest only-matching-only control group design. The population in this study is all high school class X students with a total of 288 students divided into 8 classes. In this study using the Non-probability Sampling technique in the form of purposive sampling. The samples in this study were class X E as the experimental class, totaling 36 students and class X G as the control class, totaling 36 students. The data collection technique was in the form of a non-test using a Collaboration Self-Assessment Tool (CSAT) questionnaire with 44 statement items and an oral communication skill observation sheet with 5 indicators as an aspect of observation. The data analysis technique used is the One Way Anova Test. Based on the results of the study, it was concluded that the use of differentiation learning strategies can improve students' communication and collaboration skills on environmental change materials.
Soluble DLK1 secreted by telomere-shortening-induced senescent microglia impairs myelination and alters neuronal activity
Authors: Gan Li , Liu Bangyan , Telpoukhovskaia Maria , Fan Li , Giani Alice , Torres Eileen , Zhan Lihong , Ye Pearly , Zhu Jingjie , Foxe Nessa , Zhu Daphne , Tong Xinran , Srivast Deepak , Theodoris Christina , Gong Shiaoching , Zhao Mingrui 
Published: November 2024

Abstract

Aging has a critical role in the development of neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. In the current study, we investigated the impact of aging on the brain through telomere shortening, a physiological change correlated with aging. Animals with shortened telomeres exhibit cognitive decline and exacerbated lipofuscinosis in the brain. Our single-nuclei transcriptome analysis revealed that telomere shortening led to the emergence of a senescent microglia population reminiscent of a senescence-associated secretory phenotype signature, and oligodendrocyte lineage cells with disrupted maturation and differentiation profiles. Using iPSC-derived microglia with shortened telomeres, we identified DLK1 as a novel senescence-associated ligand secreted by senescent microglia. Depletion of microglia abolished the DLK1 elevation in the cerebral spinal fluid of telomere-shortened mice. Elevation of soluble DLK1 induced demyelination and disruption of neuronal calcium signaling. Our findings highlighted the induction of microglia senescence by telomere shortening and identified DLK1 as a new senescence-associated ligand by which senescent microglia disrupts normal myelination and neuronal calcium activity.
Hospitalized children with influenza A before, during and after COVID-19 pandemic: a retrospective cohort study
Authors: Lin Fen , Liang Jian-Lian , Guan Ze-Xiang , Wu Min , Yang Li-Ye 
Published: November 2024

Abstract

Context:
Since the outbreak of COVID-19 in late 2019, the transmission dynamics and clinical presentation patterns of influenza A (Flu A) virus have undergone changes.
Objectives
This article conducted a comparative analysis in clinical characteristics and laboratory results of pediatric patients with Flu A before, during, and after the COVID-19 pandemic.
Methods
The medical records of 885 children hospitalized with Flu A virus infection at a tertiary hospital in Guangdong Province, China, were retrospectively analyzed. Flu A was confirmed in these cases using a direct immunofluorescence antigen assay. The clinical data for this study span from January 1, 2018, to May 31, 2023.
Results
In our study, we observed a total of 340 cases before the COVID-19 pandemic, 196 cases during the pandemic, and 349 cases after the pandemic. Patients after the pandemic had a higher median age on admission (5.66 years, range 3.41–7.70) and exhibited more respiratory symptoms such as cough, sore throat, and nasal stuffiness. The length of hospital stay was longer, and there was a higher percentage of patients with fever duration ≥ 5 days among Flu A patients during the pandemic. Compared to before and during the COVID-19 pandemic, Flu A patients after the pandemic showed significantly reduced white blood cell (WBC) and platelet (PLT) counts (P < 0.001), along with elevated levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in laboratory indexes (P < 0.001). Furthermore, more hospitalized children after the pandemic were diagnosed with benign acute childhood myositis (BACM).
Conclusion
Our research results indicates a significant decrease in Flu A cases during the COVID-19 pandemic, and hospitalized children with Flu A have more severe clinical symptoms after the COVID-19 pandemic. These findings have implications for public health policy and clinical management of Flu A cases.
Influence of slope angle and height on the failure mode and safety factor of a homogeneous slope in 3D using the Finite Element Method
Authors: Verma Dhananjai , Chasie Megotsohe , Mishra Akshay 
Published: November 2024

Abstract

The bearing of slope geometry on the safety factor of a predefined homogeneous slope is analysed in 3D following the finite element-based strength reduction technique for establishing the relationships and the resultant failure modes. The type of failure and shape of the sliding mass is found guided by the slope geometry. The results indicate that FOS decreases nonlinearly with increasing height but decreases linearly with increasing slope angle. This insight can guide practicing professionals from making informed designs on geometry alteration of slopes for effective stabilization.
Sacroiliac Joint Remodeling in a Post-Traumatic Child: A Case Report
Authors: Sheng li , Fan Shaohua , Sheng Xiaoyong 
Published: November 2024

Abstract

Background:
Sacroiliac joint (SIJ) remodeling in pediatric patients following trauma is a rare phenomenon, with limited documentation in medical literature. This case report presents a unique instance of post-traumatic SIJ remodeling in a child, highlighting the novel imaging findings and the successful outcome achieved through multidisciplinary care. The case contributes valuable insights into the management of pediatric SIJ injuries and the distinctive anatomical responses involved in the healing process.
Case Presentation:
An 11-year-old girl was admitted ten days after a motorbike accident, presenting with severe right hemipelvis pain and an inability to move her leg. Imaging revealed a dislocation of the right SIJ, a superior and posterior displacement of the hemipelvis, and a separation of the pubic symphysis. Initial attempts at closed reduction were unsuccessful, leading to surgical intervention with the placement of a percutaneous SIJ screw and an external fixation stent. Despite incomplete initial reduction, the patient underwent multidisciplinary rehabilitation. At three months post-operation, she was walking without pain, and CT scans showed remodeling of the SIJ, with the right joint adapting to match the sacral articular surface. The SIJ screw was removed at six months, and the patient fully returned to her pre-injury state, with equal limb lengths and no functional deficits.
Conclusions:
This case underscores the importance of recognizing the unique anatomical and physiological responses of pediatric SIJ to trauma. Timely diagnosis, multidisciplinary management, and careful consideration of growth and development are key to achieving favorable outcomes in children with post-traumatic SIJ injuries. This report highlights the potential for significant joint remodeling and the importance of tailored rehabilitation in pediatric patients.
Disseminated Histoplasmosis and Presumptive CNS Toxoplasmosis-Associated Immune Reconstitution Inflammatory Syndrome in a Patient with HIV/AIDS: A Case Report
Authors: Nicolás Laverde-Sudupe , Carr Erin , Bruno Velit-Rios , Maria Morel-Almonte , Guillermo Castro Jose 
Published: November 2024

Abstract

Background: Co-infections associated with Immune Reconstitution Inflammatory Syndrome (IRIS) have been described in literature, however they constitute an uncommon finding in the medical community.
Case presentation: Here we report a rare case of a 55-year-old woman from Cuba with prior medical history of HIV/AIDS adherent to her Highly active antiretroviral therapy (HAART) regimen, who was hospitalized in Miami because of fluid dysphagia, odynophagia and right-sided cervical lymphadenopathy. A prior biopsy of the right cervical lymph node performed in an outside hospital found evidence of non-caseating granulomas with budding yeast, which was later confirmed to be disseminated histoplasmosis by a positive (1-3)-β- glucan assay and Histoplasmosis urine antigen in this admission. Furthermore, after multiple imaging testing due to her clinical condition, a brain MRI demonstrated findings concerning for cerebral toxoplasmosis, which was supported by serology findings. Treatment with amphotericin B and TMP-SMX led to clinical and radiological improvement of this patient’s conditions, and she was discharged with an appointment for follow-up in the clinic.
Conclusion: This case highlights the complexities and challenges in managing opportunistic infections during immune recovery in HIV/AIDS patients on HAART, and emphasizes the necessity of continuous vigilant monitoring and having a broad differential diagnosis in this group of patients.
Patient satisfaction with health care service delivery in Primary Healthcare facilities in an arid and semi-arid context in Kenya
Authors: Opanga Yvonne , Barasa Chris , Sydney Jane , Mwangangi Mercy , Wangalwa Gilbert , Musombi Emmanuel , Ekal Lopodo , Ekiru Sarah , Lokoel Gilchrist , Mwanja Mark , Gikunda Aloise , Omogi Jarim , Arasio Anthony , Kiplimo Richard , Osembo Evans , Walumbe Risper , Memiah Peter , Ndirangu Meshack 
Published: November 2024

Abstract

Background: Patient satisfaction with services offered in primary healthcare (PHC) facilities is a critical factor for health outcomes especially in arid and semi-arid regions. These regions are characterized by static and migratory population necessitating differentiated primary healthcare models. This paper highlights patient satisfaction levels and its associated factors among patients attending public and faith-based organization PHC facilities in Turkana County.
Methods: The landscape analysis was conducted in Loima and Turkana Central sub-Counties. This study utilized client exit interviews to assess patient satisfaction as a measure of the quality of PHC services. Insights about daily hospital care and quality of care were assessed in PHC facilities. Patient satisfaction was measured by a single question that targeted 442 patients asking them to rate their overall satisfaction with PHC services. Factors associated with Patient satisfaction were analyzed using bivariate and multivariable logistic regression.
Results: The overall patient satisfaction with PHC services was high, with 95% of patients reporting to be satisfied. Over half (55%) and more than a third (37%) of the patients’ satisfaction with consultation and pharmacy services respectively. The satisfaction level was lowest for laboratory services (13%).15% reported to have paid for services. Two factors were significantly associated with patient satisfaction: willingness to recommend the facility to other people and means of transport used. Patients who would recommend the facility were more likely to be satisfied than those who would not (OR=8.86, p =0.005). Patients who used a motorbike were less likely to be satisfied than those who walked to the facility as their means of transport (OR=0.21, p=0.008).
Conclusion: Patient satisfaction with PHC services in Turkana County is influenced by social determinants factors linked to access to the PHC facilities. In such contexts, patient satisfaction can be improved by addressing gaps associated with location and distance of the facility, means of transport used to access PHC facilities and willingness to recommend the facility. These findings have implications for policy makers, health managers, and health workers and brings out the need to consider such factors in designing PHC service delivery models in similar settings.
Nanocarrier-Mediated Enhancement of Fusidic Acid’s Anti-Bacterial Activity: A Comparative Analysis of Its Niosomal and Liposomal Delivery Systems
Authors: Rehman Mujeeb-ur- , Inayat Seema , Arsala Hafiza , Hussain Saadat , Noreen Shagufta , Din Fakhar ud , Maharjan Rukesh 
Published: November 2024

Abstract

Biofilms are group of bacteria that are protected by a slimy layer. These biofilms are more resistant to antibiotics than individual bacteria which are the basic building blocks of biofilms. Researchers are actively introducing new treatments that are supposed to be more efficient in fighting biofilms and to be less toxic to the patient than the conventional antibiotics. Here in this study we propose the development of Fusidic acid (FA) loaded liposomes and niosomes to improve the anti-bacterial activity in-vitro against Staphylococcus aureus strains. The designed niosomes and liposomes of FA were smaller in size ranging from 116.4 to 274.2 nm displaying homogeneity in terms of size distribution with PdI 0 and zeta potential ranging from 20 to 60 mV. The nanoparticles were stable for 30 days irrespective of the storage condition, 4oC and Room temperature. SEM analysis confirmed spherical type nanoparticles and diameter of the nanoparticles were complementary with DLS (NanoZetaSizer) results. All types of nanoparticles showed higher entrapment of FA, particularly FA-Span-40 NPs showed %EE of 94%, rest of the nanoparticle showed %EE 85%. The niosomal and liposomal formulations of FA modified the biological behavior of the drug and provided better in vitro performance against S. aureus compared to the standard (FA). Span-40, Tween-20 and cationic liposomes MIC value (0.039 - 0.078 µg/mL) were effective and comparable with standard, FA (0.04 µg/mL). Furthermore, the effectiveness of antibacterial agents at a microscopic scale was carried out using AFM and SEM after contact of the niosomal-formulation with Staphylococcus aureus strains. Greater change in the structural and mechanical properties of biofilms was observed for tween-20, Span-40 niosomes, PEGylated and Cationic liposomes compared to control and standard FA showing efficacious antibacterial activity. The study demonstrates the designed nano formulations could be a useful strategy to enhance the efficacy of antimicrobials agents.
Kinematic Status of Bryan and Mobi-C Artificial Cervical Discs Post Cervical Hybrid Surgery: A Retrospective Study
Authors: Ma Yukun , Xiong Yang , Wang Ting , Yu Xing , Li Chuanhong , Meng Letian , Zhao He , Yang Yongdong , Zhao Dingyan , Wang Fengxian , Qu Yi 
Published: November 2024

Abstract

Objective: To examine the mid-term efficacy and imaging results of using the Mobi-C and Bryan after cervical hybrid surgery on 2-level cervical spondylolisthesis. To observe their postoperative changes and differences in the flexion-extension center of rotation (FE-COR) of the anterior cervical disc replacement (ACDR) segment.
Methods: Patients who underwent cervical hybrid surgery between June 2014 and June 2019 were included. The mJOA, NDI, and VAS scores were used to assess clinical outcomes and the FE-COR of the ACDR segment was measured. Pre-operative and 36 months’ radiographs were collected to compare the range of motion (ROM) in the total cervical spine, ACDR segmental ROM, and operated adjacent segmental ROM. The translation distance of the Mobi-C and Bryan was measured. The degree of disc degeneration in the adjacent segment and bony fusion of the ACDF segment were observed.
Results: eighty-one patients were included (40 cases in Mobi-C group and 41 cases in Bryan group). All patients have shown improvements in their post-operative mJOA, NDI, and VAS scores (P＜0.05). The C2-C7 ROM decreased in both groups (P<0.05). There was no significant decrease in ACDR segmental ROM and upper or lower adjacent segmental ROM compared with preoperatively (P>0.05). No significant difference were found between the two groups in the above ROM measurement (P＞0.05). For the Mobi-C group, the follow-up compared with pre-surgery showed statistical significance both in the FE-COR-X (44.86±7.70% vs. 57.13±8.45%, P<0.05) and FE-COR-Y (52.29±12.71% vs. 34.47±10.32, P<0.05). For the Bryan group, there was no significant difference at the follow-up in the FE-COR-X and FE-COR-Y compared with pre-surgery (P>0.05). No significant difference in the translation distance between the two groups was observed (P>0.05). All the ACDF segments were in a stable condition. Twenty-two out of 162 adjacent segments showed imaging ASD (9 cases in Mobi-C group and 13 cases in Bryan group). In the Mobi-C group, there were mild in 6 cases and moderate in 3 cases. In the Bryan group, there were mild in 8 cases and moderate in 5 cases.
Conclusions: The cervical hybrid surgery using both Mobi-C or Bryan artificial cervical discs can achieve satisfactory results. The FE-COR of Mobi-C segment will shift forward and downward. The FE-COR of Bryan segment is relatively closer to the pre-operative condition. Changes in the FE-COR after hybrid surgery in both the Mobi-C and Bryan segments might not affect clinical outcomes.
Reshaping the Undegraduate Curriculum Development and Delivery through Visual Analytics
Authors: Fatima Saman , Khan Rehan Ahmed , Arooj Mahwish 
Published: November 2024

Abstract

Background
Visual analytics, as a powerful tool, can aid in planning and implementing future changes to the curriculum mapping, thereby ensuring that medical education aligns with the ever-evolving needs of the healthcare system. However, there has been a lack of empirical studies exploring the potential benefits and methodologies of utilizing visual analytics to reshape medical education curricula. The study aimed to describe the use of visual analytics to analyse part of a curriculum for an undergraduate dental program.
Methods
A qualitative document analysis of the part of a curriculum for the undergraduate dental program at Bakhtawar Amin Medical and Dental College was conducted to identify flaws and propose improvements. The software ATLAS.ti version 9 was used to analyze the relationships among different components of the Behavioral Sciences subject. One-to-one interviews with subject specialists and medical education experts were conducted to gather insights and suggestions for fulfilling the gaps, improved curriculum redesign using visual analytics. Data triangulation was employed to bolster the validity and reliability of the findings.
Results
The results show eleven different aspects categorized into four major categories, identified after analysis of a part of the curriculum for an undergraduate dental program. ATLAS.ti facilitated the visualization of relationships between designed and delivered curricula including; (i) outcome discrepancies, (ii) alignment of learning outcomes and teaching methodologies, (iii) the relationship between learning outcomes and assessment, and (iv) a comprehensive gap analysis of learning outcomes, teaching methodologies and assessment.
Conclusion
The findings emphasize the importance of visual analytics in curriculum mapping. The application of visual analytics enables curriculum developers and educators to uncover hidden patterns in educational data and create a well-aligned curriculum that meets the evolving needs of the healthcare system. Further exploration of visual analytics in diverse educational contexts offers promising opportunities for research in the areas of health informatics, information technology, and medical education.
FcRγIIA attenuates cutaneous leishmaniasis by modulating Lyn, Fyn and SHP-1 activity
Authors: Hammi Ikram , Giron-Michel Julien , Riyad Myriam , Akarid Khadija , Arnoult Damien 
Published: November 2024

Abstract

Background
Leishmania is responsible for a neglected tropical disease affecting millions of people around the world and could potentially spread more due to climate change. Despite the complexity and effectiveness of the immune response, the parasite has developed many strategies to evade it and to take control of the host cell in favor of its replication. These evasion strategies start at earlier stages of the infection by hijacking immune receptors to silence the cellular response.
Methods
For in vivo studies, CD32a transgenic mice and the corresponding WT were infected with Leishmania major Friedlin strain. For in cellulo studies, BMDMs isolated from WT or CD32a transgenic mice, as well as differentiated control or CD32a knock down THP-1 were infected with 2 species of Leishmania, Leishmania major and Leishmania Tropica.
Results
We have investigated how Leishmania may use the Fc receptor FcγRIIA/CD32a and the signaling pathways downstream to evade the host immune response. In vivo, expression of FcγRIIA/CD32a accelerates the signs of inflammation but prevents the formation of necrotic lesions after Leishmania infection. In infected macrophages, the presence of FcγRIIA/CD32a does not affect the secretion of pro-inflammatory cytokines while the balance between ITAMa and ITAMi proteins is disturbed with an improved Fyn and Lyn activation. Unexpectedly, infection with Leishmania tropica but not Leishmania major triggered an intracytoplasmic processing of FcγRIIA/CD32a.
Conclusions
Our observations underscore the significance of FcγRIIA/CD32a in cutaneous leishmaniasis and its possible use as a therapeutic target.