bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of adverse outcome in uterine smooth muscle tumours of uncertain malignant potential (STUMP): a clinicopathological analysis of 22 cases with a proposal for the inclusion of additional histological parameters
Authors: Gupta Mamta , Laury Anna L , Nucci Marisa R , Quade Bradley J 
Published: March 2018

AimsThe current World Health Organisation classification defines smooth muscle tumours of uncertain malignant potential (STUMPs) as neoplasms that cannot be diagnosed reliably as benign or malignant according to generally accepted criteria. This has led to the application of various sets of criteria; consequently, consistent and reliable outcome data are lacking. The aims of this study were: (i) to compare the frequency of adverse outcome in STUMP on the basis of enhanced criteria; and (ii) to perform failure analysis to identify feature(s) helpful in predicting outcomeMethods and resultsCases of STUMP diagnosed between 1994 and 2009 were retrieved and follow‐up data were collected. Morphological parameters were scored and correlated with outcome. Twenty‐two subjects with a median follow‐up of 74.5 months (range, 26–166 months) formed the study group. Their age ranged from 31.9 years to 51.8 years (median, 45.3 years). Sixteen subjects underwent hysterectomy and six underwent myomectomy. Adverse outcomes were noted in eight (36.4%) cases. In cases with adverse outcomes, notable features included moderate–severe nuclear atypia (seven), epithelioid features (one), infiltrative or irregular margins (five), atypical mitoses (two), and vascular intrusion (three)ConclusionsThe frequency of adverse outcomes in our series (36.4%) was higher than that in previously published reports (7–26.7%), suggesting that the use of more stringent criteria can exclude some patients from further follow‐up. Although ‘significant’ nuclear atypia was not discriminatory, its frequent association with adverse outcomes has pathobiological implications. The presence of necrosis was not particularly associated with adverse outcomes. Atypical mitoses, epithelioid differentiation, vascular involvement and infiltrative/irregular margins appear to herald adverse outcomes, and therefore merit inclusion in the diagnostic regimen.
Effectiveness of nurse‐led video interventions on anxiety in patients having percutaneous coronary intervention
Authors: Haddad Nibras E. , Saleh Mohammad N. , Eshah Nidal F. 
Published: March 2018

AbstractAimManaging anxiety is essential to control anxiety‐related complications. This study aimed to evaluate the effectiveness of a nurse‐led video‐based educational intervention on anxiety levels among patients undergoing a percutaneous coronary intervention.MethodsA pre‐test, post‐test quasi‐experimental design was used. Between June 2015 and July 2016, 99 participants were allocated to comparison versus intervention groups, and a video‐based educational intervention about the percutaneous coronary intervention was provided to the intervention group. The State Anxiety Inventory was used to measure anxiety levels at baseline, 2 hours before, and 4 to 6 hours after a percutaneous coronary intervention.ResultsAfter providing the video‐based intervention, at 2 hours before the procedure, results showed a statistically significant difference in anxiety mean scores (33.08 versus 60.88) between the intervention and comparison groups, respectively (P < 0.001). At 4 to 6 hours after the procedure, the anxiety mean score for the intervention group (M = 24.1) was statistically significantly lower than that of the comparison group (M = 44.17; P < 0.001).ConclusionsA pre‐procedure nurse‐led educational intervention provided by video had a significant effect on reducing anxiety levels among patients undergoing percutaneous coronary intervention. Patients in the intervention group experienced a steady and consistent trend of anxiety reduction pre‐cutaneous and post‐percutaneous coronary intervention.
First‐principles study in an inter‐granular glassy film model of silicon nitride
Authors: Ching Wai‐Yim , Yoshiya Masato , Adhikari Puja , Rulis Paul , Ikuhara Yuichi , Tanaka Isao 
Published: March 2018

AbstractBased on a previously constructed intergranular glassy film (IGF) model for bulk silicon nitride, a large periodic model of 3864 atoms containing 2 grains of different orientations from the main bulk β‐Si3N4 and 2 IGFs was fully relaxed using the ab initio density‐functional theory package VASP. The relaxed structure was then used to calculate the electronic structure, density of states, interatomic bonding, partial charge distribution, and electron localization using the OLCAO method. Analysis of the data focuses on the interfacial regions between bulk β‐Si3N4 and the Si‐O‐N glass layer with different orientations. The total bond order density (TBOD) is evaluated in different interfacial and bulk regions. We show minor differences in the internal cohesion between crystalline grains of different facets. However, the overall charges in the bulk crystal grains and in the glassy regions are electropositive which are balanced by the negatively charged interfacial region between the two. The presence of a less rigid glassy layer is the reason for structural flexibility in ceramics without a huge penalty in the steric energy. The optimization of the interfacial structure and bonding via the creation of defective sites is the atomic origin for the existence of the IGF in silicon nitride. The insights obtained from this detailed quantum mechanical analysis of a realistic IGF model are discussed including implications on the strength, fracture toughness, and processing methods. We also discuss the potential applications of our method to other complex materials systems.
CiRS‐7 targeting miR‐7 modulates the progression of non‐small cell lung cancer in a manner dependent on NF‐κB signalling
Authors: Su Chongyu , Han Yi , Zhang Hongtao , Li Yunsong , Yi Ling , Wang Xiaojue , Zhou Shijie , Yu Daping , Song Xiaoyun , Xiao Ning , Cao Xiaoqing , Liu Zhidong 
Published: March 2018

AbstractThe purpose of this study was to figure out the effect of ciRS‐7/miR‐7/NF‐κB axis on the development of non‐small cell lung cancer (NSCLC). In response, the expressions of ciRS‐7, miR‐7 and NF‐κB subunit (ie RELA) within NSCLC tissues and cell lines were determined with real‐time polymerase chain reaction (RT‐PCR) and Western blot. Moreover, the NSCLC cells were transfected with pcDNA3‐ciRS‐7‐ir, pcDNA3‐ciRS‐7, miR‐NC and miR‐7 mimic. Furthermore, the targeted relationships between ciRS‐7 and miR‐7, as well as between miR‐7 and RELA, were confirmed by luciferase reporter assay. The proliferation, migration and apoptosis of NSCLC cells were, successively, measured using CCK‐8 assay, wound‐healing assay and flow cytometry test. Consequently, ciRS‐7, miR‐7, histopathological grade, lymph node metastasis and histopathological stage could independently predict the prognosis of patients with NSCLC (all P < .05). Moreover, remarkably up‐regulated ciRS‐7 and RELA expressions, as along with down‐regulated miR‐7 expressions, were found within NSCLC tissues and cells in comparison with normal ones (P < .05). Besides, overexpressed ciRS‐7 and underexpressed miR‐7 were correlated with increased proliferation, migration and invasion, yet reduced apoptosis rate of NSCLC cells (P < .05). More than that, ciRS‐7 specifically targeted miR‐7 to reduce its expressions (P < .05). Ultimately, the NSCLC cells within miR‐7 + RELA group were observed with superior proliferative, migratory and invasive capabilities than those within miR‐7 group (P < .05), and RELA expression was also significantly modified by both ciRS‐7 and miR‐7 (P < .05). In conclusion, the ciRS‐7/miR‐7/NF‐kB axis could exert pronounced impacts on the proliferation, migration, invasion and apoptosis of NSCLC cells.
S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen‐glucose deprivation‐induced neuroinflammation via inhibiting TLR2/4‐NFκB signalling
Authors: Dong Yin‐Feng , Guo Ruo‐Bing , Ji Juan , Cao Lu‐Lu , Zhang Ling , Chen Zheng‐Zhen , Huang Ji‐Ye , Wu Jin , Lu Jun , Sun Xiu‐Lan 
Published: March 2018

AbstractFingolimod (FTY720) is used as an immunosuppressant for multiple sclerosis. Numerous studies indicated its neuroprotective effects in stroke. However, the mechanism remains to be elucidated. This study was intended to investigate the mechanisms of phosphorylated FTY720 (pFTY720), which was the principle active molecule in regulating astrocyte‐mediated inflammatory responses induced by oxygen‐glucose deprivation (OGD). Results demonstrated that pFTY720 could protect astrocytes against OGD‐induced injury and inflammatory responses. It significantly decreased pro‐inflammatory cytokines, including high mobility group box 1 (HMGB1) and tumour necrosis factor‐α (TNF‐α). Further, studies displayed that pFTY720 could prevent up‐regulation of Toll‐like receptor 2 (TLR2), phosphorylation of phosphoinositide 3‐kinase (PI3K) and nuclear translocation of nuclear factor kappa B (NFκB) p65 subunit caused by OGD. Sphingosine‐1‐phosphate receptor 3 (S1PR3) knockdown could reverse the above change. Moreover, administration of TLR2/4 blocker abolished the protective effects of pFTY720. Taken together, this study reveals that pFTY720 depends on S1PR3 to protect astrocytes against OGD‐induced neuroinflammation, due to inhibiting TLR2/4‐PI3K‐NFκB signalling pathway.
Retracted: MicroRNA‐140‐5p elevates cerebral protection of dexmedetomidine against hypoxic–ischaemic brain damage via the Wnt/β‐catenin signalling pathway
Authors: Han Xin‐Rui , Wen Xin , Wang Yong‐Jian , Wang Shan , Shen Min , Zhang Zi‐Feng , Fan Shao‐Hua , Shan Qun , Wang Liang , Li Meng‐Qiu , Hu Bin , Sun Chun‐Hui , Wu Dong‐Mei , Lu Jun , Zheng Yuan‐Lin 
Published: March 2018

AbstractHypoxia–ischaemia (HI) remains a major cause of foetal brain damage presented a scarcity of effective therapeutic approaches. Dexmedetomidine (DEX) and microRNA‐140‐5p (miR‐140‐5p) have been highlighted due to its potentially significant role in the treatment of cerebral ischaemia. This study was to investigate the role by which miR‐140‐5p provides cerebral protection using DEX to treat hypoxic–ischaemic brain damage (HIBD) in neonatal rats via the Wnt/β‐catenin signalling pathway. The HIBD rat models were established and allocated into various groups with different treatment plans, and eight SD rats into sham group. The learning and memory ability of the rats was assessed. Apoptosis and pathological changes in the hippocampus CA1 region and expressions of the related genes of the Wnt/β‐catenin signalling pathway as well as the genes responsible of apoptosis were detected. Compared with the sham group, the parameters of weight, length growth, weight ratio between hemispheres, the rate of reaching standard, as well as Bcl‐2 expressions, were all increased. Furthermore, observations of increased levels of cerebral infarction volume, total mortality rate, response times, total response duration, expressions of Wnt1, β‐catenin, TCF‐4, E‐cadherin, apoptosis rate of neurons, and Bax expression were elevated. Following DEX treatment, the symptoms exhibited by HIBD rats were ameliorated. miR‐140‐5p and si‐Wnt1 were noted to attenuate the progression of HIBD. Our study demonstrates that miR‐140‐5p promotes the cerebral protective effects of DEX against HIBD in neonatal rats by targeting the Wnt1 gene through via the negative regulation of the Wnt/β‐catenin signalling pathway.
Progress in scaffold‐free bioprinting for cardiovascular medicine
Authors: Moldovan Nicanor I. 
Published: March 2018

AbstractBiofabrication of tissue analogues is aspiring to become a disruptive technology capable to solve standing biomedical problems, from generation of improved tissue models for drug testing to alleviation of the shortage of organs for transplantation. Arguably, the most powerful tool of this revolution is bioprinting, understood as the assembling of cells with biomaterials in three‐dimensional structures. It is less appreciated, however, that bioprinting is not a uniform methodology, but comprises a variety of approaches. These can be broadly classified in two categories, based on the use or not of supporting biomaterials (known as “scaffolds,” usually printable hydrogels also called “bioinks”). Importantly, several limitations of scaffold‐dependent bioprinting can be avoided by the “scaffold‐free” methods. In this overview, we comparatively present these approaches and highlight the rapidly evolving scaffold‐free bioprinting, as applied to cardiovascular tissue engineering.
Street foods in Beirut city: An assessment of the food safety practices and of the microbiological quality
Authors: Loukieh Myriam , Mouannes Emilio , Abou Jaoudeh Chantal , Hanna Wakim Lara , Fancello Francesco , Bou Zeidan Marc 
Published: March 2018

AbstractStreet food is a prevalent part of the food service industry. It is convenient in terms of accessibility and cost, but perceived as potential risk of foodborne illness. Accordingly, the safety of street foods in Beirut, Lebanon was assessed using an observational checklist and microbiological analyses. A total of 30 vendors were observed for their food safety parameters and 60 samples were analyzed for their content of Escherichia coli, Staphylococcus aureus, Listeria spp., and Salmonella spp., then, statistical analyses were performed for possible correlations. Results showed unsatisfactory levels of foodborne pathogens. Microbiological contamination was significantly correlated to unproper environmnental surroundings, deficiency of potable water, money handling, inappropriate methods of refrigeration, and the limited access to improper disposal facilities near stalls. These findings reveal the microbiological quality of street foods served in Beirut, and highlight on the practices to be ameliorated to provide safe street food products to consumers.Practical applicationsStreet food emerges as a social adaptation in urban areas due to its rapid lifestyle hence it may present a public health risk due to various factors. The current study is the first of its kind to be conducted in Beirut and its results present solid basis for further practices at different levels. Divulgation of its results would lead to new governmental laws to protect the public health and reduce the economic burdens related to hospitalization due to foodborne pathogens and poisoning. Educational institutions would also be involved in applications related to training and awareness sessions for street food handlers, to teach them the good hygienic practices. This study will also help consumers identify good and bad hygienic practices thus choose appropriate street food handlers.
Prior Work and Educational Experience Are Not Associated With Successful Completion of a Master's‐Level, Distance Education Midwifery Program
Authors: Niemczyk Nancy A. , Cutts Alison , Perlman Dana B. 
Published: March 2018

IntroductionIn order to increase and diversify the midwifery workforce, admissions criteria for midwifery education programs must not contain unnecessary barriers to entry. Once accepted, students need to successfully complete the program. Many admissions criteria commonly used in midwifery education programs in the United States are not evidence based and could be unnecessary barriers to education. The primary objective of this study was to identify factors known during the admission process that were related to successful completion or failure to complete a midwifery program educating both student nurse‐midwives (SNMs) and student midwives (SMs); a secondary objective was to quantify reasons for program noncompletion.MethodsThis master's‐level, distance education program educates a diverse group of both SNMs and SMs. A pilot, retrospective cohort study examined all students matriculating at the program from fall 2012 on and scheduled to graduate by summer 2016 (N = 58). Demographic information, admissions information, academic records, and advising notes were reviewed. Reasons for noncompletion were identified, and characteristics were compared between students who did and did not complete the program.ResultsProgram completion was not significantly associated with students’ status as nurses prior to admission, labor and delivery nursing experience, length of nursing experience, nursing degree held, presence of children at home, working while in school, or undergraduate grade point average.DiscussionBeing a nurse, years of nursing experience, type of nursing degree, or labor and delivery nursing experience were not associated with completion of this midwifery program.
Use and Efficacy of Information Technology in Innovation Processes: The Specific Role of Servitization
Authors: Kroh Julia , Luetjen Heiner , Globocnik Dietfried , Schultz Carsten 
Published: March 2018

Innovation activities and, particularly, service innovations, impose high demands on a firm's information processing capabilities. IT tools are supposed to support internal and external information flows, thereby improving a firm's information processing capabilities. However, past research is indecisive about how IT tools influence innovation performance. Furthermore, past research has not considered that services have an increasingly relevant role in a firm's innovation portfolio that can complicate information processing. This study therefore draws on information processing theory and service innovation literature to develop a conceptual model that explains how IT use intensity—depending on the firm's business focus—affects innovation program performance. By using a cross‐industry, multi‐informant sample of the innovation programs of 116 firms, which were collected from 887 informants, this article provides empirical evidence that (i) intensive IT use in order to exchange information with internal and external stakeholders improves the firm‐wide market knowledge, which in turn has a positive impact on a firm's innovation program performance; (ii) the performance impact of market knowledge becomes stronger with increasing degrees of servitization; (iii) a higher degree of servitization reduces IT's use intensity. This research demonstrates the dilemma that servitized firms face: Their business focus hinders the use of IT tools, although the latter will enable them to gain more benefits from the improved market knowledge they create.Practitioner Points

Intensive IT use positively influences the firm‐wide innovation performance. The intensive use of IT tools to strengthen internal information flows and IT tools to support exchange with external stakeholders increase a firm's market knowledge, which enhances the innovation program performance.
Service innovations have higher information requirements than product innovations and profit therefore more from intensive IT use, but services' complexity hinders IT implementation.
Firms with a higher degree of servitization use less IT, although they can profit more from the market knowledge IT tools create. Servitized firms need to install a flexible, modular, and open IT system for efficient IT use and to include all relevant internal and external stakeholders.
Comparative and functional anatomy of the mantle margin in ark clams and their relatives (Bivalvia: Arcoidea) supports association between morphology and life habits
Authors: Audino J. A. , Marian J. E. A. R. 
Published: March 2018

AbstractEvaluating the association between ecology and the evolution of morphological traits is a central question of macroevolutionary studies. The Arcoidea comprises several lineages of epibyssate (epifaunal) and endobyssate (semi‐infaunal or infaunal) bivalves, which makes them a suitable model for analyzing the implications of similar life habits on phenotype. Also, the families currently assigned to the clade (Arcidae, Cucullaeidae, Glycymerididae, and Noetiidae) exhibit great variation in the mantle margin, a region responsible for interacting with the surrounding environment and provided with sensory structures (e.g., photoreceptor organs). Consequently, this anatomical region includes traits relevant for testing hypotheses of morphological attributes associated with lifestyles. For this purpose, we investigated the detailed anatomy of the mantle margin of three arcoidean species (i.e., Arca imbricata, Barbatia candida, and Arcopsis adamsi) applying integrative microscopy, and complemented the study with basic morphological analysis of 27 species obtained in museum collections. Secretory cells, muscle fibers and sensory organs are described in detail, including sensory ciliated cells of the inner mantle fold, reported for the first time. Our results corroborate a very reduced to absent middle fold in arcoideans, with transfer of sensory functions to the first outer and inner folds. Moreover, our data indicates association of some pallial characters with life habits, i.e., presence of pallial pigmentation and photoreceptor organs in epibyssates, and development of an enlarged pallial curtain in endobyssates, which should stimulate further investigations on these potentially adaptive morphological features.
Complex movement patterns by foraging loggerhead sea turtles outside the breeding season identified using Argos‐linked Fastloc‐Global Positioning System
Authors: Dujon Antoine M. , Schofield Gail , Lester Rebecca E. , Papafitsoros Kostas , Hays Graeme C. 
Published: March 2018

AbstractWe used Argos‐linked Fastloc‐Global Positioning System (Argos‐linked Fastloc‐GPS) satellite tags to investigate how loggerhead sea turtles use neritic foraging habitats at multiple scales. Out of 24 turtles, six individuals used more than one foraging site, with all sites being separated by >25 km. These six individuals used up to four sites, remaining at each site for a mean of 150 days and returning to the same site a minimum of 52 days later. The other 18 turtles remained in a single site. The area within sites was not used uniformly, with 15 out of 24 turtles exhibiting complex movement patterns within and amongst up to five focal patches, which were typically 0.1–5.0 km apart within a single site. Movements between sites and patches might sometimes have reflected overwintering behaviour; however, similar movement patterns occurred at multiple times of the year, suggesting other factors were also involved. Use of multiple sites and patches might be driven by differences in resource availability, such as food and/or night‐time refuges, competition, or exploratory movement to investigate or locate alternative patches. We confirmed competition via direct visual observations of aggressive interactions between individuals at one foraging patch. Our results illustrate the importance of standardizing data to the same number of locations per day and night to accurately delineate key areas used by turtles or for evidence‐based marine protected area planning.