bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Findings on the SNP18 Sequence and Its Functional Analysis in Hygienic Behavior of Apis mellifera
Authors: Kibar Mustafa , Negiş İnci Şahin , Aytekin İbrahim 
Published: December 2024

ABSTRACTHygienic behavior (HB) is a crucial biological mechanism in honeybees that is associated with disease resistance. This study aimed to investigate the effect of the SNP18 sequence and environmental factors on the HB of honey bees, using a total of 14 colonies and 148 bee samples from seven different bee breeds. Association analysis revealed that colonies with Italian hybrids (IH) or young queens statistically (p < 0.01) exhibited high hygienic behavior (HHB). HB increased by 71.6% when the number of frames in the colony, representing colony power (CP), increased by one (p < 0.05). In restriction fragment length polymorphism (RFLP) analysis, novel mutations in the MlyI polymorphism of the SNP18 sequence were firstly found in Apis mellifera. In addition, the restriction fragments of the novel variants of the SNP18 HHB and SNP18 low hygienic behavior (LHB) lines were determined by sequencing. In this study, several important findings emerged: Due to one‐base differences in the restriction fragment, this sequence could not be genotyped by RFLP. Honeybees could be homozygous (HHB or LHB) or heterozygous (HHB and LHB) for the SNP18. SNP18 sequence could be located in different regions of the chromosome and could only be determined by genome sequencing. Finally, since genotypes cannot be clearly determined, no specific allele or genotype can be recommended for HB selection in beekeeping. Therefore, additional research is required to assess discovered novel variants for genetic selection of HHB for ecological beekeeping, healthy products and sustainability.
3D Electrical Resistivity Tomography Using a Radial Array and Detailed Topography for Tumuli Prospection
Authors: Karaoulis Marios , Tsokas Grigorios N. , Tsourlos Panagiotis , Bogiatzis Petros , Vargemezis George 
Published: December 2024

ABSTRACTTumuli, ancient burial mounds, stand as intriguing archaeological features, offering valuable insights into past cultures and burial practices. This paper explores the significance of tumuli inspection and utilizes electrical resistivity tomography (ERT) as a noninvasive and powerful tool for inspecting these enigmatic structures, using a nonconventional array. Tumuli, spanning various shapes and sizes, serve as repositories of cultural and funerary traditions, and understanding their internal composition is crucial for unravelling historical narratives. ERT has emerged as a promising geophysical method for investigating subsurface structures, including tumuli. By imaging the electrical resistivity of the ground, ERT enables archaeologists to map variations in soil composition and identify buried features without excavation. This paper reviews the principles of ERT and its application in tumulus studies, showcasing a case study where ERT has successfully revealed internal structures, burial chambers and associated artefacts. The use of 2D ERT is common in tumuli inspection, ignoring accurate 3D effects from the topography. Here we highlight the benefits of the 3D inversion, while we provide a different way to measure which is cost efficient and provides increased spatial resolution to the area of interest. The integration of 3D ERT into archaeological investigations not only enhances our understanding of tumuli construction but also preserves these cultural heritage sites by minimizing the need for invasive excavation. This research contributes to the evolving methodologies in archaeology, emphasizing the synergy between modern technology and traditional archaeological inquiry to uncover the secrets held within tumuli.
Outcomes following intradetrusor onabotulinumtoxinA in a national cohort of nursing home residents
Authors: Dreyfuss Leo D. , Nik‐Ahd Farnoosh , Wang Lufan , Shatkin‐Margolis Abigail , Covinsky Kenneth , Boscardin W. John , Suskind Anne M. 
Published: December 2024

AbstractObjectivesTo determine predictors of treatment success and complications following intradetrusor onabotulinumtoxinA injections among a large cohort of nursing home (NH) residents, representing one of the most frail and vulnerable populations in the United States.Materials and methodsThis is a retrospective cohort study of long‐stay NH residents who underwent onabotulinumtoxinA injections between 2014 and 2016. Residents were identified using the Minimum Data Set (MDS) linked to Medicare claims. Frailty was measured using the Claims‐based Frailty Index and socioeconomic status using the Area Deprivation Index (ADI; higher ADI = increasing social deprivation). The primary outcome was treatment success, defined as repeat onabotulinumtoxinA injection within 1 year of index injection. Secondary outcomes included 30‐day complications and urinary retention, defined as new indwelling urinary catheters identified on the MDS at 3 months.ResultsOnabotulinumtoxinA injections were performed in 1683 NH residents. Mean age was 78.2 years, 74% were female and 22.8% had an indwelling urinary catheter at baseline. A total of 38.4% of residents had ≥1 30‐day complication and 14.6% had a new catheter at 3 months. Repeat injections were performed in 34.3% of residents within 1 year. Repeat injections were more likely among residents who were female [adjusted relative risk (aRR) 1.29; 95% CI 1.08–1.54] and who had a baseline catheter (aRR 1.30; 95% CI 1.11–1.52). Residents who were ≥85 years (aRR 0.78; 95% CI 0.64–0.96) and those in the lowest quartile ADI (aRR 0.75; 95% CI 0.61–0.93) were less likely to undergo repeat injections.ConclusionAmong this population of NH residents, who are by definition frail and comorbid, rates of repeat onabotulinumtoxinA injections are comparable to retrospective analyses of younger adults and independent of frailty and comorbidity. Based on these findings, surgeons should consider the entire clinical picture when evaluating patients for onabotulinumtoxinA injections and should not necessarily exclude those who are frail or comorbid from this potentially quality‐of‐life‐improving therapy.
Board Remuneration, Remuneration Committee, and Earnings Management in a Two‐Tier System for Company Sustainable Development
Authors: Putra Ferdy , Setiawan Doddy , Hartoko Sri , Arifin Taufiq 
Published: December 2024

ABSTRACTThis study aims to analyze the effect of directors' and board of commissioners' remuneration on earnings management using the remuneration committee as a moderating variable. Using a sample of Indonesian non‐financial companies from 2014 to 2023 and using multiple regression analysis and moderated regression analysis, we found that directors' remuneration has a positive effect, while the board of commissioners' remuneration has a negative effect on earnings management. The remuneration committee negatively moderates the effect of directors' remuneration and positively moderates the effect of the board of commissioners' remuneration on earnings management. These results also remain consistent when using alternative measurements and the endogeneity test. We found many companies do not yet have a remuneration committee, so corporate governance can still be improved. This study has practical and theoretical contributions to increasing knowledge about agency theory, earnings management, and factors that can align the interests of directors, boards of commissioners, and shareholders so that the company's sustainable development can continue to be improved.
Environmental and Social Performance, Firm Value, and the Role of Sustainability Committee
Authors: Rini Rima Kusuma 
Published: December 2024

ABSTRACTThe presence of a specific role, such as a sustainability committee, is crucial for enhancing environmental and social performance and increasing market value. This study aims to examine the direct relationship between sustainability committee to environmental and social performance, as well as between environmental and social performance and firm value to provide additional evidence among mixed findings from previous result. The moderating relationship of the sustainability committee given the significant outcomes in the direct relationship between environmental and social performance and firm value. Using 11 years data in Indonesia, the sustainability committee has positive significant to environmental and social performance. Social performance has positive significant to firm value while environmental does not. Additionally, sustainability committee strengthens the relationship between environmental performance and firm value while social performance is not. These findings portray the importance of sustainability committee to both leverage the environmental and social performance, as well as firm value. The Difference‐in‐Difference (DiD) analysis reveals that, following POJK No. 51/2017, sustainability committee significantly impacts environmental and social performance and firm value, though with negative way. This distinction result provides additional insight since in short‐term the sustainability role still perceived in negative ways. This study contributes to the literature by presence of the role sustainability committee, which no previous studies documented in developing country and difference governance mechanisms such as Indonesia. The limitation of data sustainability committee recommends the future study should consider the role sustainability responsibilities in other committees, identify the characteristics and performance of sustainability committee.
Chemoselective Anaerobic Dehydrogenation of Alcohols by Using Visible Light and a Positively Charged Deazaflavin Catalyst Regenerated by Acetonitrile Solvent
Authors: Obertík Róbert , Ludvíková Lucie , Chudoba Josef , Cibulka Radek 
Published: December 2024

AbstractThree series of novel deazaflavinum salts differing in their substitutions at positions 5 (R = H, phenyl, or mesityl), 7, and 8 (R = OMe, Me, H, or Cl) were synthesized as potential catalysts of a novel chemoselective visible light‐mediated anaerobic oxidation of primary and secondary alcohols to carbonyl compounds. This mild procedure uses acetonitrile as a solvent, which acts simultaneously as a sacrificial electron acceptor (in place of the oxygen usually used in photooxidation reactions), and therefore the reaction does not need any additives. Structure and properties‐versus‐catalytic activity studies identified 5‐mesityl‐7,8‐dimethoxy‐3‐methyldeazaflavinium chloride (3a‐Cl) as the most potent catalyst. 3a‐Cl was effective in non‐deuterated acetonitrile (CH3CN), unlike its original 5‐phenyl analogue 2a‐Cl, which is efficient only in deuterated solvent (CD3CN). This difference arises because the regeneration of the 2a‐Cl catalyst is slower in CH3CN than in CD3CN. Our method using the optimized 3a‐Cl photocatalyst and CH3CN as a sacrificial oxidant and solvent in one is a useful addition to synthetic organic chemistry. Anaerobic conditions prevent side oxygenation reactions and overoxidations that usually occur in air or oxygen. This property makes this method suitable for dehydrogenations of alcohols that possess additional group(s) sensitive to oxygenation.
Carbon Monoxide and Alkoxycarbonyl Radical Enabled Migration Strategy for the Carbonylative Functionalization of Unactivated Alkenes
Authors: Hou Ming , Wang Yuanrui , Yang Hefei , Zhang Jiajun , Wu Xiao‐Feng 
Published: December 2024

AbstractHerein we report a “carbonylative migration” strategy for the acylation‐esterification type double functionalization of unactivated alkenes using alkyloxalkyl chlorides and CO as the reagents. The transformation is proceeded by the alkoxycarbonyl radical addition to unactivated alkenes, followed by the insertion of carbon monoxide to induce intramolecular migration of heteroaryl groups, which is different from the traditional reaction modes. The reaction conditions were mild and well tolerated with varieties of functional groups. A variety of 1,4‐dicarbonyl compounds with different ester groups were produced easily which has high potential applications in biology, medicine, and other fields.
Evaluating Red Blood Cells' Membrane Fluidity in Diabetes: Insights, Mechanisms, and Future Aspects
Authors: Pitocco Dario , Hatem Duaa , Riente Alessia , Giulio Michele Maria De , Rizzi Alessandro , Abeltino Alessio , Serantoni Cassandra , Tartaglione Linda , Rizzo Emanuele , Paoli Lorenzo Lucacchini , Spirito Marco De , Maulucci Giuseppe 
Published: December 2024

ABSTRACTAimsThis review evaluates the mechanisms underlying red blood cell (RBC) membrane fluidity changes in diabetes mellitus (DM) and explores strategies to assess and address these alterations. Emphasis is placed on developing a comprehensive index for membrane fluidity to improve monitoring and management in diabetic patients.Materials and MethodsWe reviewed current literature on RBC membrane fluidity, focussing on lipid composition, glycation, oxidative stress, and lipid transport alterations in diabetic patients. Key methodologies include lipidomics, multi‐scale probe assessment, and machine learning integration for standardized fluidity measurement.ResultsDiabetic RBCs exhibit increased membrane fluidity, primarily due to oxidative stress, increased glycation, and dysregulated lipid composition. These alterations contribute to vascular complications and impair RBC functionality. Assessing membrane composition as a nutritional marker provides insights into the metabolic impacts of glycaemic management.ConclusionsThere is a critical need for a unified and comprehensive membrane fluidity index in DM, which could support personalised interventions through dietary, medicinal, and lifestyle modifications. Future research should prioritise standardising measurement techniques and integrating lipidomic data with machine learning for predictive modelling, aiming to enhance clinical outcomes for diabetic patients.
Children's Books as a Tool for Raising Young Readers' Awareness of Dyslexia
Authors: Lise Lemoine , Emmanuelle Bonjour , Benoît Schneider , Nathalie Marec‐Breton 
Published: December 2024

ABSTRACTFrench law requires children with disabilities to receive schooling, wherever possible in ordinary schools. To achieve this goal, schools must create a truly inclusive environment that meets every child's specific needs. Ensuring other students accept peers with disabilities is an essential part of providing an inclusive environment. We postulated that reading children's books featuring characters with disabilities can foster this acceptance by enabling students to understand and empathise with peers with disabilities. Indeed, readers' tendency to attribute emotions, beliefs, intentions and perceptions to characters helps them better appreciate characters' feelings, mental states and experiences. The present study analysed the impact that reading a children's book about a young boy with dyslexia had on children without dyslexia. We read Les mots d'Enzo to 25 fourth‐ and fifth‐grade students (13 girls and 12 boys) and then conducted semi‐structured interviews with each student. Reading Les mots d'Enzo taught participants a lot about dyslexia, the difficulties it causes, its consequences for children with dyslexia and the help these children need. In addition to gaining a relatively accurate understanding of dyslexia, participants grasped the story's moral, attributed emotions, beliefs and intentions to the character with dyslexia, appreciated how he felt, and showed empathy towards him. They were also capable of generalising these aspects to real students with dyslexia or other disorders.
Parafoveal Processing and Transposed‐Letter Effects in Developmental Dyslexic Reading
Authors: Kirkby Julie A. , Barrington Rhiannon S. , Drieghe Denis , Liversedge Simon P. 
Published: December 2024

ABSTRACTDuring reading, adults and children independently parafoveally encode letter identity and letter position information using a flexible letter position encoding mechanism. The current study examined parafoveal encoding of letter position and letter identity for dyslexic children. Eye movements were recorded during a boundary‐change paradigm. Parafoveal previews were either an identity preview (e.g., nearly), a transposed‐letter preview (e.g., enarly) or a substituted‐letter preview (e.g., acarly). Dyslexic readers showed a preview benefit for identity previews, indicating that orthographic information was encoded parafoveally. Furthermore, dyslexic readers benefitted from transposed‐letter previews more than substituted‐letters previews, demonstrating that letter identity was encoded independently to letter position during parafoveal processing. Although a transposed‐letter effect was found for dyslexic readers, they demonstrated a reduced sensitivity to detect transposed‐letters in later measures of reading, that is, go‐past times, relative to that found for typically developing readers. We conclude that dyslexic readers, with less rich and fully specified lexical representations, have a reduced sensitivity to transpositions of the first two letters of the upcoming word in preview. These findings are compatible with the view that orthographic representations of dyslexic children are not sufficiently specified.
Implicit Statistical Learning of Brazilian Children With Developmental Dyslexia
Authors: Ardiles Roseline , Custódio Eda Marconi , dos Santos Suelen Nascimento , de Oliveria Matheus Assis 
Published: December 2024

ABSTRACTImplicit statistical learning (ISL) is non‐conscious learning where participants identify patterns in their environment after repeated exposures. This study verified whether Brazilian children with DD present disturbances in the ISL mechanism and if these disturbances may be related to the difficulties associated with DD through artificial grammar learning (AGL) and reaction time in serial tasks (SRT Task). It also intended to verify which of the paradigms proves to be the most sensitive to assess ISL and which is most associated with participants' learning to read and write. Two groups of children with and without DD from the end of the first cycle and the beginning of the second cycle of the elementary school participated in this study, paired according to socioeconomic level, education network, schooling, gender and age. Children with DD showed no disturbances in the ISL process; the AGL paradigm exhibited the most significant association with performance on reading/writing tasks. When compared to the SRT Task, the AGL paradigm proved to be more sensitive in assessing implicit processes and effectively distinguishing between the groups with and without DD. The results of the SRT Task emphasise the importance of task practice and structure for implicit learning in children with developmental dyslexia. These findings have important implications for understanding ISL and its relevance to reading and writing skills in children with developmental dyslexia.
E‐52862—A selective sigma‐1 receptor antagonist, in peripheral neuropathic pain: Two randomized, double‐blind, phase 2 studies in patients with chronic postsurgical pain and painful diabetic neuropathy
Authors: Gálvez Rafael , Mayoral Victor , Cebrecos Jesús , Medel Francisco J. , Morte Adelaida , Sust Mariano , Vaqué Anna , Montes‐Pérez Antonio , Neira‐Reina Fernando , Cánovas Luz , Margarit César , Bouhassira Didier 
Published: December 2024

AbstractBackgroundWe report the efficacy and safety of E‐52862—a selective, sigma‐1 receptor antagonist—from phase 2, randomized, proof‐of‐concept studies in patients with moderate‐to‐severe, neuropathic, chronic postsurgical pain (CPSP) and painful diabetic neuropathy (PDN).MethodsAdult patients (CPSP [N = 116]; PDN [N = 163]) were randomized at a 1:1 ratio to 4 weeks of treatment with E‐52862 (CPSP [n = 55]; PDN [n = 85]) or placebo (CPSP [n = 61]; PDN [n = 78]) orally once daily. Pain intensity scores were measured using a numerical pain rating scale from 0 (no pain) to 10 (worst pain imaginable). The primary analysis population comprised patients who received study drug with ≥1 baseline and on‐treatment observation (full analysis set).ResultsIn CPSP, mean baseline average pain was 6.2 for E‐52862 vs. 6.5 for placebo. Week 4 mean change from baseline (CFB) for average pain was −1.6 for E‐52862 vs. –0.9 for placebo (least squares mean difference [LSMD]: −0.9; p = 0.029). In PDN, mean baseline average pain was 5.3 for E‐52862 vs. 5.4 for placebo. Week 4 mean CFB for average pain was −2.2 for E‐52862 vs. –2.1 for placebo (LSMD: –0.1; p = 0.766). Treatment‐emergent adverse events (TEAEs) were reported in 90.9% of E‐52862‐treated patients vs. 76.7% of placebo‐treated patients in CPSP and 34.1% vs. 26.9% in PDN. Serious TEAEs occurred in CPSP only: E‐52862: 5.5%; placebo: 6.7%.ConclusionsE‐52862 demonstrated superior relief of CPSP vs. placebo after 4 weeks. Reductions in pain intensity were seen in PDN with E‐52862; high placebo response rates may have prevented differentiation between treatments. E‐52862 had acceptable tolerability in both populations.Significance StatementThese proof‐of‐concept studies validate the mode of action of E‐52862, a selective sigma‐1 receptor antagonist. In CPSP, E‐52862 resulted in clinically meaningful pain relief. In PDN, reductions in pain intensity were seen with E‐52862; high placebo response rates may have prevented differentiation between E‐52862 and placebo. These findings are clinically relevant given that neuropathic pain is highly incapacitating, lacking effective treatments and representing a significant unmet medical need, and support further development of sigma‐1 receptor antagonists for peripheral neuropathic pain.