bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factitious thyrotoxicosis: how to find it
Authors: Vorasart Pakaworn , Sriphrapradang Chutintorn 
Published: March 2019

Abstract

Background
Although the most common cause of thyrotoxicosis is Graves’ disease, the determination of the cause of thyrotoxicosis is important for establishing appropriate management. Diagnosis of surreptitious ingestion of thyroid hormones or factitious thyrotoxicosis often presents a difficult challenge especially in a patient with previously diagnosed Graves’ disease. The objective of this report was to demonstrate various approaches to support the diagnosis of factitious thyrotoxicosis.

Case presentation
We describe a patient with underlying Graves’ disease who underwent definitive therapy and needed long-term levothyroxine (LT4) replacement therapy. Later she developed thyrotoxicosis. Although factitious thyrotoxicosis was suspected because of very low thyroid uptake and low thyroglobulin (Tg) levels with the absence of thyroglobulin antibodies (TgAbs), she still refused any medication or substance use. After the administration of bile acid sequestrant, the thyroid hormone levels rapidly returned to normal within 1 month.

Conclusions
The diagnosis of factitious thyrotoxicosis is based upon the absence of goiter, suppressed serum Tg level, decreased radioactive iodine (RAI) uptake, and excellent response after cholestyramine treatment.
Production and Storage Properties of Spray-Dried Red Beet Extract Using Polysaccharide-Based Carrier Systems
Authors: Zuanon Larissa A. C. , Fuzari Nathália C. , Ferreira Sungil , Freitas Mírian L. F. , Moser Poliana , Nicoletti Vânia R. 
Published: March 2019

Abstract
This study aimed to produce betalain-rich powders by spray drying red beet extract using modified starch and maltodextrin blends as carrier materials, as well as to investigate the product storage stability as affected by water sorption and light exposure. The influence of spray drying conditions and carrier blends on the process yield, water content and solubility of the powders, betalain retention, and color parameters was assessed using a central composite design 24. The results of this screening allowed selection of four samples to further evaluation concerning their morphological characteristics, particle size distribution, water sorption properties, and betalain stability under light exposure. Samples formulated with carrier blends composed of equal amounts of modified starch and maltodextrin, used in a concentration of 35 g carriers/110 g of initial solution resulted in the higher betalain stability during 98 days of storage under exposure to light. Even though this formulation showed similar water sorption behavior to the other formulations studied, it also showed the best mechanical properties, indicating lower susceptibility to powder collapse.
Single- and Dual-Stream Foam Fractionation of Protein – Exploring a Simple and Effective System to Improve Fundamental Understanding
Authors: Yan Lihua , Xiao Jie , Kirk Tim V , Chen Xiao Dong 
Published: March 2019

Abstract
In this paper, a single-/dual-stream foam separation device was constructed to simplify the conventional foam fractionation process (CFFP), by minimizing interactions between bubbles. This was expected to help reveal mechanisms in a ‘neat’ way. Results have shown negligible productivity of single-stream foam fractionation (SSFF) for the protein enrichment ratio (E) under conditions tested, whereas dual-stream foam fractionation (DSFF) was established as a reasonable basic unit of CFFP. The influence of DSFF operating conditions, such as the inlet protein concentration and gas velocity, were examined. Calculations of protein concentration and liquid volume were performed via foam thickness measurement, which is very difficult with CFFP. It was evident that the middle drainage channel played a key role in enrichment phenomena. The current DSFF system provides a control case for evaluating principles of foam fractionation. Furthermore, a simple mass-balance model has been proposed to represent the column-wide behavior of DSFF.
Performance Analysis of 4×10 Gbps OFDM-PON System Over ROF Link
Authors: Koundal Anjali , Dewra Sanjeev 
Published: March 2019

Abstract
In this paper, an OFDM-ROF-PON transmission system at bit rate of 4×10 Gbps is proposed and demonstrated. This paper analyzes orthogonal frequency division multiplexing system for radio over fiber in passive optical network at different input powers. A laser source of 193.1 THz is used with single mode fibers of length 400 km and 500 km. A transmission bit rate of 10 Gbits/sec is used to simulate the OFDM-ROF-PON system. The performance of the system has been analyzed with acceptable Quality Factor and Bit Error Rate at low signal input power in the presence of fiber non-linearities. Also the system does not use any amplifiers and the work is done at higher bit rates. It is analyzed that as the input power increases quality factor also increases and bit error rate decreases.
Hopf bifurcation and stability in a Beddington-DeAngelis predator-prey model with stage structure for predator and time delay incorporating prey refuge
Authors: Xiao Zaowang , Li Zhong , Zhu Zhenliang , Chen Fengde 
Published: March 2019

Abstract
In this paper, we consider a Beddington-DeAngelis predator-prey system with stage structure for predator and time delay incorporating prey refuge. By analyzing the characteristic equations, we study the local stability of the equilibrium of the system. Using the delay as a bifurcation parameter, the model undergoes a Hopf bifurcation at the coexistence equilibrium when the delay crosses some critical values. After that, by constructing a suitable Lyapunov functional, sufficient conditions are derived for the global stability of the system. Finally, the influence of prey refuge on densities of prey species and predator species is discussed.
Periodic solution for ϕ-Laplacian neutral differential equation
Authors: Yao Shaowen , Cheng Zhibo 
Published: March 2019

AbstractThis paper is devoted to the existence of a periodic solution forϕ-Laplacian neutral differential equation as follows$$\begin{array}{} (\phi(x(t)-cx(t-\tau))')'=f(t,x(t),x'(t)). \end{array}$$By applications of an extension of Mawhin’s continuous theorem due to Ge and Ren, we obtain that given equation has at least one periodic solution. Meanwhile, the approaches to estimate a priori bounds of periodic solutions are different from the corresponding ones of the known literature.
An Evaluation Method for the Skeleton Structure of Cement-Stabilized Crushed Rock Material Using X-Ray CT Images
Authors: Li Zhi , Liu Jian 
Published: March 2019

Abstract
No appropriate or accurate skeleton evaluation indexes currently exist for cement-stabilized crushed rock materials (CCRMs). To establish new skeleton evaluation indexes for a CCRM, different skeleton tightness–influenced regions of coarse aggregates were defined and compared to accurately capture the degree of tightness of a skeleton based on computed tomography images. The skeleton denseness index (φ¯) and skeleton stability index (φ¯) were proposed. Moreover, φ¯ was used to evaluate a CCRM that was compacted using the vertical vibration compaction method (VVCM) with different gradations to verify its feasibility. The meso-skeleton and macroscopic indexes (maximum dry density and compressive strength) of a CCRM with different compaction methods and vibration times, along with a field CCRM, were measured and compared. The results show that a range with twice the equivalent radius is rational as the influenced region. The φ¯ of a CCRM compacted using VVCM decreases as the gradation becomes finer, revealing that φ¯ can capture a CCRM skeleton. A CCRM compacted using a quasistatic compaction method has smaller meso-skeleton and macroscopic indexes than a CCRM using VVCM or a field CCRM; all indexes of the CCRM applying VVCM increase as the vibration time increases, whereas the growth rate slows. The results of vibration compaction (90 s) for CCRM match the common outdoor compaction results when constructing semirigid bases (common gradation and cement dosage) in Guangdong Province, China. Moreover, a strong correlation exists between meso-skeleton evaluation indexes and the compressive strength for a 7-day period.
A felnőttkori hypolactasia születésikohorsz-vizsgálata
Authors: Buzás György Miklós 
Published: March 2019

Abstract: Introduction and aim: To assess the prevalence of lactase gene promoter C/T13910 phenotypes in patients with lactose intolerance symptoms and to analyze the birth-cohort phenomenon in lactose-intolerant patients. Method: 1266 patients consulted between 2010 and 2017 were enrolled. Five-year cohort periods of patients born before 1939 and after 1995 were defined and the prevalence of C/T13910 phenotypes was calculated. C/T13910 phenotypes were determined by polymerase chain reaction. Results: The prevalence of the CC phenotype was 43.1%, TC was detected in 44.3% and TT in 12.6% of the cases. The prevalence of the CC phenotype showed a non-linear incremental increase in females, from 9.13% in those born before 1939 to 37.7% in those born after 1995. Conclusion: The prevalence of CC phenotype raised incrementally in females, suggesting a gender/hormonal influence. Orv Hetil. 2019; 160(14): 549–554.
Fermentasi Pucuk Tebu (Saccharum officinarum L) Menggunakan Trichoderma Harzianum : Degradasi in Sacco Komponen Serat
Authors: Suryadi Suryadi , Syarif Suhessy , Darlis Darlis , Afdal Muhammad 
Published: March 2019

ABSTRAK. Pucuk tebu (Saccharum officinarum L) (PT) merupakan salah satu pakan alternatif yang dapat dimanfaatkan sebagai sumber pakan bagi ternak ruminansia. Penelitian bertujuan untuk mengetahui degradasi in sacco komponen serat PT yang difermentasikan dengan beberapa level Trichoderma harzianum. Penelitian ini menggunakan Rancangan Acak Lengkap dengan 4 perlakuan dan 5 ulangan, pengaruh perlakuan terhadap parameter yang diuji menggunakan analisis sidik ragam dan dilanjutkan dengan uji lanjut Duncan kalau ada perbedaan antar perlakuan. Pucuk tebu difermentasi dengan perlakuan Trichoderma harzianum dengan beberapa level yaitunya 0, 2, 4 dan 6% selama 1 minggu. Pucuk tebu hasil fermentasi digiling untuk dijadikan bubuk dengan ukuran saringan 2 mm kemudian dengan teknik in sacco diinkubasi ke dalam rumen sapi berfistula selama 72 jam. Peubah yang diukur adalah degradasi NDF, ADF dan hemiselulosa dari PT yang telah difermentasi sesuai dengan perlakuan. Hasil penelitian ini menunjukkan bahwa level T. Harzianum berpengaruh tidak nyata (P 0.05) terhadap degradasi NDF dan ADF dari PT fermentasi tetapi berpengaruh sangat nyata (P 0.01) terhadap degradasi hemiselulosa. Kesimpulan penelitian adalah degradasi NDF, ADF dan hemiselulosa dari PT fermentasi terbaik dicapai pada perlakuan dengan menggunakan 4% T. harzianum dibandingkan dengan perlakuan lainnya.(The fermentation of Saccharum officinarum L. shoot using Trichoderma harzianum: in sacco degradation of fiber component)ABSTRACT. Sugar can (Saccharum officinarum L) shoot (SCS) is one of an alternative feed that could be use as a source of feed for ruminant. The aim of this study was to reveal the in sacco degradation of SCS fermented with some level of Trichoderma harzianum. The design of this experiment was Completely Randomized Design with 4 treatments and 5 replications. The statistical analysis used in this experiment was Analysis of Variance and followed by Duncan Tets. Sugar can shoot was fermented with T. harzianum in some levels of 0, 2, 4 dan 6% for one week. The fermented SCS was dried, grounded in 2 mm mash and kept store until incubated. To evaluate the in sacco degradation, fermented SCS was incubated for 72 h. Parameters measured were the degradation of NDF, ADF dan hemiselulosa of treated SCS. Results showed that the level of T. harzianum did not significantly (P 0.05) affect on the degradation of NDF and ADF but it siginficantly (P 0.01) affected on the degradation of hemiselulosa. It could be concluded that the level of 4 % of T. harzianum in fermenting SCS showed the best in sacco degradation of NDF, ADF dan hemiselulosa among all treatments.
Pemberian Ekstrak Daun Katuk (Sauropus androgynus L. Merr) dalam Air Minum Kambing Peranakan Ettawa untuk Meningkatkan Produksi dan Kualitas Susu
Authors: Yustendi Dedhi , Mardhiah Ainal 
Published: March 2019

ABSTRAK. Penelitian dilaksanakan pada kelompok ternak kambing perah di Desa Geucee Kayee Jatoe Kota Banda Aceh. Penelitian menggunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan persentase pemberian ekstrak daun katuk dalam air minum yaitu S0, S1, S2 dan S3 (0 %; 10%; 20 %, dan 30% ), tiap perlakuan diulang sebanyak 4 kali. Data volume produksi air susu yang diperoleh dianalisa dengan ANOVA, dan bila terdapat perbedaan, maka dilanjutkan dengan uji lanjut Duncan. Hasil penelitian menunjukkan pengaruh yang nyata (P0.05) terhadap volume air susu yang dihasilkan antar perlakuan S0, S1, S2 dan S3. Pemberian ekstrak daun katuk 10% (S1) dalam air minum memperlihatkan peningkatan produksi susu dan kualitas susu yang baik dibandingkan dengan pemberian 20% dan 30% dalam air minum. (Giving katuk leaf extract (Sauropus androgynus L. Merr) in drinking water Ettawa crossbreed goats to increase milk volume and milk quality) ABSTRACT. This research was carried out on a group of Ettawa crossbreed goats in Geucee Kayee Jatoe, Banda Aceh. This study used a completely randomized design with 4 (four) treatments of giving katuk leaves extract in drinking water, namely S0, S1, S2 and S3 (0%; 10%; 20%, and 30% of katuk leaf) and each group repeated 4 times. Data on milk production were analyzed by analysis of variant (ANOVA), and if there were differences, then followed by Duncan multiple range test (DMRT). The results showed that there was no significant effect (P 0.05) on the production of milk between treatments S0, S1, S2 and S3. Giving katuk leaf extract up to 10% (S1) in drinking water increase in milk production and quality compared to those giving 20% and 30% of katuk leaf.
Pengaruh Pemberian Kulit Nanas (Ananas comosus L. Merr) Fermentasi terhadap Persentase Karkas dan Kolesterol Ayam Potong
Authors: Noviandi Idham , Yaman M. Aman , Rinidar Rinidar , Nurliana Nurliana , Razali Razali 
Published: March 2019

ABSTRAK. Penelitian dilakukan untuk mengetahui pengaruh pemanfaatan kulit nanas dalam pakan fermentasi terhadap persentase karkas dan kolesterol daging ayam potong. Rancangan yang digunakan adalah Rancangan Acak Lengkap (RAL) dengan ternak percobaan sebanyak 80 ekor anak ayam umur 2 hari selama tiga puluh lima hari yang diacak dan dibagi menjadi empat perlakuan dan empat ulangan. Adapun perlakuan ransum disusun berdasarkan tingkat penggunaan kulit nanas yang difermentasi, yaitu: P1 (0,0%), P2 (10%), P3 (20%), dan P4 (30%). Parameter yang diamati adalah persentase karkas dan kolesterol daging ayam potong. Data yang diperoleh dianalisis dengan sidik ragam menggunakan rancangan acak lengkap dan bila terdapat perbedaan dilanjutkan dengan uji Duncan’s Multiple Range Test (DMRT). Hasil penelitian menunjukkan bahwa pakan yang mengandung kulit nanas difermentasi dalam pakan komersil berpengaruh nyata menurunkan (P0,05) persentase karkas dan menurunkan kadar kolesterol pada ayam potong. Dari hasil penelitian disimpulkan bahwa kulit nanas yang difermentasi dalam pakan komersil pada ayam potong mampu menurunkan persentase karkas dan kolesterol pada daging dada ayam potong. (Effect of green leather generation (Ananas comosus L. Merr) fermentation on the percentage of carcass and cholesterol chicken pieces) ABSTRACT. The study was conducted to determine the effect of pineapple skin utilization in fermented feed on carcass and cholesterol percentage of chicken meat. The design used is Completely Randomized Design (RAL) with experimental as many as 80 day old chicken (DOC) aged 2 days, randomly selected, divided into four treatments and four replications and treated for thirty five days. The ration treatment was prepared based on the level of fermented pineapple skin use, namely: P1 (0,0%), P2 (10%), P3 (20%), and P4 (30%). The parameters observed were the percentage of carcass and cholesterol of chicken meat. The data obtained were analyzed by using analysis of variance (ANOVA) and if the were differences followed by Duncan's Multiple Range Test (DMRT) test. The results showed that feed containing fermented pineapple skin significantly decreased (P 0,05) percentage of carcass and lower cholesterol levels in chicken meat. It can be concluded that the utilization of fermented pineapple skin in commercial feed have a significant effect on reducing the percentage of carcass and cholesterol in chicken breast meat.
Clinical and Functional Outcomes of Lens-Iris Diaphragm Implantation with Simultaneous Subtotal Penetrating Keratoplasty: a 15-Year Follow-Up Case Report
Authors: Kalinnikov Yu. Yu. , Sobolev N. P. , Novikov S. V. , Zinov’eva A. V. , Nevrov D. V. 
Published: March 2019

Combined traumatic injuries of the anterior eye segment are attributed to the severe consequences of the injured organ of vision. Iris defects result in spherical and chromatic aberrations, diplopia, flares, severe photophobia, cosmetic defects, and significantly reduced visual acuity after the injury. The literature describes various methods to restore visual functions impaired as a result of aniridia. Use of an artificial iris together with an intraocular lens pathology results in optimal reconstruction and recovery of normal anterior segment anatomy and topography. In this paper, we provide a report on a patient followed up for 15 years after combined reconstruction eye surgery for an off-the-job penetrating eye injury sustained in 2003. A complex intervention was required due to the involvement of the cornea, iris, and lens. In 2004, the patient underwent a lens-iris diaphragm implantation combined with penetrating keratoplasty. The diaphragm implantation was followed by an improvement in visual acuity and elimination of photophobia and flares. There were no intra- or postoperative complications. Two years later, LASIK refractive surgery was performed on the corneal transplant to eliminate induced ametropia. The patient retained good eye function, with a stable position of the lens-iris diaphragm, for many years after the diaphragm implantation, keratoplasty, and refractive surgery. In 2018, he had an intravitreal implant impregnated with dexamethasone, as changes in the retina had developed. The long-term follow-up in this case demonstrates that the implantation of a lens-iris diaphragm resulted in an elimination of undesirable optical events associated with aniridia and produced an optimal functional result, while also improving the patient’s quality of life with a good aesthetic effect.
Chronic Endophthalmitis after Cataract Phacoemulsification. Сlinical Case
Authors: Frolychev I. A. , Pashtaev N. P. , Pozdeyeva N. A. , Sycheva D. V. 
Published: March 2019

A clinical case of chronic postoperative endophthalmitis treatment after cataract phacoemulsification is described in the article. The patient received vitrectomy with lens posterior capsule discission and tamponade of vitreal cavity by perfluororganic compound (up to 14 days) and 1mg vancomicin +2.25 mg ceftazidim intravitreally, also anterior chamber washing by 0.5 ml saline containing 5 mg vancomicin. Anterior chamber washing by antibiotics and intravitreal injection of antibacterial medicine combination was repeated on the second and third day after the surgery. This tactics of treatment allowed to save lens capsular bag and intraocular lens. Purpose. To assess efficacy and safety of new treatment method in the patient with chronic postoperative endophthalmitis. Patient B, 65 years old applied to clinic with complaints on the pain in the right eye, visual acuity decrease up to finger counting near face. Symptoms started to disturb in 2 weeks after cataract extraction with IOL implantation. During 6 months courses of antibacterial therapy including vancomicin (antibiotic of reserve) there were no positive dynamics. Cornea edema, multiple precipitates at endothelium and intraocular lens were defined at biomicroscopy; 2.5 mm hypopyon in anterior camera; fibrin in pupil projection; exudation in vitreous cavity. Laser tyndalmetry data (albumen flow in anterior chamber) confirmed inflammation strong enough — 173 f/ms. Surgical treatment according the described method was rendered to the patient. In the postoperative period we saw stable visual functions, uncorrected visual acuity was 0.6, corrected — 0.8. Patient noted the absence of pain and eye’s reddening decrease. At biomicroscopy we observed considerable inflammation decrease, almost total absence of precipitates at cornea endothelium. Laser tyndalmetry data confirmed inflammation decrease, albumen flow in anterior chamber was 17.6 f/ms. Endothelial cells’ loss after surgery was 142 cells/1 mm2 (5.61 %). According to electrophysiologic investigation and ERG there was no deviation from normal values was revealed. This treatment method allows to restore visual functions rather quickly and can be used in case of inefficient lengthy conservative therapy.
Possibilities of Complex Ultrasound Examination in the Assessment of Hemodynamic and Structural Features of Retinal Capillary Hemangioma
Authors: Neroev V. V. , Kiseleva T. N. , Ilyukhin P. A. , Ramazanova K. A. , Ryabina M. A. , Novikova A. Y. 
Published: March 2019

Purpose: to study the possibilities of complex ultrasound examination in the assessment of hemodynamic and structural features of retinal capillary hemangioma (RCH).Patients and methods. 26 patients (35 eyes) with RCHs at the age of 11 to 53 years (mean 26.6 ± 9.4 years) were examined. Ultrasound examination was performed using B–mode image, echodensitometry, Color Doppler Imaging (CDI) and pulsed Doppler (PD). The peak systolic velocity (Vsyst), the end-diastolic velocity (Vdiast) of the blood flow, and the resistance index (RI) in the orbital vessels were examined using CDI and PD. Qualitative and quantitative assessment of blood flow in a feeding artery and a draining vein of the RCHs were performed. The follow-up efficiency evaluation of the laser coagulation of RCH was performed in 12 eyes.Results. The elevation of RCH was 1.7 ± 0.7 mm (from 0.5 to 3.3 mm) on average, the base diameter — 5.4 ± 2.1 mm (from 1.8 to 11.5 mm). The acoustic density varied from 42 to 176 (mean 109.6 ± 30.9) in relative units. The indices of Vsyst were from 5.5 to 21.4 cm/s (mean value — 10.6 ± 4.2 cm/s) in the feeding arteries, from 3.06 to 14.3 cm/s — in veins (mean value — 4.9 ± 2.4 cm/s). A significant increase in the blood flow velocity in the central retinal vein (CRV), a decrease in RI in the central retinal artery (CRA) and short posterior ciliary arteries (SPCAs) were determined. In 3 (8.6 %) eyes, in the absence of echographic manifestations of small RCHs of optic nerve head (ONH), there was an increase of the blood flow velocity in the CRV (the mean value was 8.95 ± 1.15 cm/s). After treatment, B-scan ultrasonogram showed no visualization of RCHs in 3 eyes. A significant decrease (31 %) of prominence compared to the baseline values was registered in 9 eyes (66.7 %). A decrease of the tumor base the diameter by an average of 37.7 % was also registered in 7 eyes (58.3 %). A significant decrease (26.3 %) in Vsyst in arterial-type feeding vessels was determined.Conclusion. Significant changes in regional ocular blood flow in RCH were registered. The increase of blood flow in the CRV at the localization of RCH on the ONH can be an additional differential diagnostic criterion of the disease. The hemodynamic instability in the retinal vessels feeding the RCH and the positive dynamics of the blood flow after laser coagulation were determined.