bluuebunny/crossref_metadata_2025_split huggingface dataset:
P2RY12:rs7637803 TT variant genotype increases coronary artery aneurysm risk in Kawasaki disease in a southern Chinese population
Authors: Lu Zhaoliang , Xu Yufen , Fu Lanyan , Tan Yaqian , Che Di , Huang Ping , Pi Lei , Zhou Huazhong , Liang Xiaoyun , Zhang Li , Gu Xiaoqiong 
Published: December 2018

AbstractBackgroundActivated‐platelet increases the risk of thrombosis in Kawasaki disease (KD) patients with a coronary artery aneurysm (CAA). The ADP pathway is one of the platelet activation and aggregation pathways. The P2RY12 gene encodes the ADP receptor that is highly concentrated on platelets. However, few studies have reported on P2RY12 in relation to KD susceptibility with or without CAA.MethodsWe recruited 1335 healthy controls and 776 KD patients, including 103 with CAA, and selected five P2RY12 polymorphisms: rs9859538, rs1491974, rs7637803, rs6809699 and rs2046934. The present study focused on the relationship between the P2RY12 polymorphisms and KD with or without CAA.ResultsAmong all of the selected polymorphisms, single‐locus analysis showed no significant association between the P2RY12 polymorphism and KD susceptibility. However, we found a significant relationship between rs7637803 and CAA risk in KD patients [CT versus CC: odds ratio (OR) = 0.41, 95% confidence interval (CI) = 0.22–0.75; p = 0.0041; TT versus CC: OR = 2.90, 95% CI = 1.12–7.46; p = 0.0276]. Stratification analysis by age in KD patients indicated that the rs7637803 TT genotype increased CAA formation risk among children aged (OR = 3.90, 95% CI = 1.42–10.69; p = 0.0081) and increased the onset risk of CAA in males (OR = 6.28, 95% CI = 2.01–19.65; p = 0.0016). The combined effect of the five selected P2RY12 risk genotypes with the KD patients compared to non‐mutated P2RY12 genotypes (score: 0) showed that patients with P2RY12 genotype polymorphisms (score: 1–5) had a significantly increased CAA risk (p = 0.0086). Stratification analysis for the severity of CAA found that the rs7637803 TT genotype reduced giant CAA (GCAA) risk (OR = 4.60, 95% CI = 1.70–12.41; p = 0.0026).ConclusionsThe results of the present study indicate that the P2RY12 rs7637803 genotype might be used as a biomarker to predict the occurrence of GCAA.
Impact of maternal HIV exposure, feeding status, and microbiome on infant cellular immunity
Authors: Dzanibe Sonwabile , Jaspan Heather B , Zulu Michael Z , Kiravu Agano , Gray Clive M 
Published: December 2018

Abstract
At least one-third of infants born in sub-Saharan Africa have been exposed to the effects of maternal HIV infection and antiretroviral treatment. Intrauterine HIV exposure is associated with increased rates of morbidity and mortality in children. Although the mechanisms responsible for poor infant health with HIV-1 exposure are likely to be multifactorial, we posit that the maternal environment during gestation and in the perinatal period results in altered infant immunity and is possibly the strongest contributing factor responsible for the disproportionally high infectious events among HIV-exposed infants who remain HIV uninfected. This review provides a synthesis of studies reporting the impact of intrauterine HIV exposure, feeding practices, and microbiota on immune ontogeny in the first year of life in HIV-exposed uninfected infants.
Review on the impact of HIV exposure, feeding practices and microbiota on immune ontogeny in HIV exposed uninfected infants.
Update on immunogenetics of Tunisian endemic pemphigus foliaceus
Authors: Masmoudi Hatem , Abida Olfa , Masmoudi Abderrahmen , Turki Hamida 
Published: December 2018

Abstract
Pemphigus foliaceus (PF) is an autoimmune blistering skin disease characterized by the presence of bullous skin lesions, the absence of mucous tissue involvement, and the production of auto-antibodies directed against a keratinocyte transmembrane protein localized in the desmosome and member of the cadherines, desmoglein 1. These pathogenic auto-antibodies are responsible for the intra-epidermal formation of blisters through the loss of keratinocyte adhesion, the so-called acantholysis process. The endemic form of PF observed in the south of Tunisia is characterized by a significantly higher incidence rate compared to the sporadic form in northern countries, occurrence mainly in young women and the absence of cases during childhood. Tunisian endemic PF is an ideal research model for the decryption of the puzzle of genetic and environmental factors and their interactions in the development of autoimmune diseases. In this review, we will summarize recent findings regarding the epidemiologic and immunologic features of Tunisian PF and its genetic and environmental factors.
Review of recent findings regarding the epidemiologic and immunologic features of Tunisian PF and its genetic, environmental and hormonal factors.
Optimization of rs‐fMRI parameters in the Seed Correlation Analysis (SCA) in DPARSF toolbox: A preliminary study
Authors: Karpiel Ilona , Klose Uwe , Drzazga Zofia 
Published: December 2018

AbstractThere are a number of various methods of resting‐state functional magnetic resonance imaging (rs‐fMRI) analysis such as independent component analysis, multivariate autoregressive models, or seed correlation analysis however their results depend on arbitrary choice of parameters. Therefore, the aim of this work was to optimize the parameters in the seed correlation analysis using the Data Processing Assistant for Resting‐State fMRI (DPARSF) toolbox for rs‐fMRI data received from a Siemens Magnetom Skyra 3‐Tesla scanner using a whole‐brain, gradient‐echo echo planar sequence with a 32‐channel head coil. Different ranges of the following parameters: amplitude of low‐frequency fluctuation (ALFF), Gaussian kernel at FWHM and radius of spherical ROI for 109 regions were tested for 20 healthy volunteers. The highest values of functional connectivity (FC) correlations were found for ALFF 0.01–0.08, spherical ROIs with the 8‐mm radius and Gaussian kernel 8 mm at FWHM in all the studied areas that is, Auditory, Sensimotor, Visual, and Default Mode Network. The dominating influence of ALFF and smoothing on values of FC correlations was noted.
Higher serum VGF protein levels discriminate bipolar depression from major depressive disorder
Authors: Chen Suzhen , Jiang Haitang , Hou Zhenhua , Yue Yingying , Zhang Yuqun , Zhao Fuying , Xu Zhi , Li Yinghui , Mou Xiaodong , Li Lei , Wang Tianyu , Zhao Jingjing , Han Chongyang , Sui Yuxiu , Wang Ming , Yang Zhong , Lu Yan , Zhu Yifeng , Li Jianhua , Shen Xinhua , Sun Fei , Chen Qingsong , Yuan Yonggui 
Published: December 2018

AbstractMisdiagnosis between major depressive disorder (MDD) and bipolar depression (BD) is quite common. Our previous study found significantly lower serum VGF (non‐acronymic) in MDD patients. However, it is unclear whether same changes occur in BD patients. Therefore, we aimed to investigate the relationship between serum VGF levels in BD and MDD patients. General information, scores of 17‐item Hamilton Depression Rating Scale (HDRS), and fasting blood samples of all participants including 30 MDD patients, 20 BD patients, and 30 healthy controls (HC) were collected. Serum VGF levels were measured by Enzyme‐linked immunosorbent assay kits. Pearson correlation analysis was used to analyze correlations between serum VGF levels and clinical information. Receiver operating characteristic (ROC) curve and likelihood ratios (LRs) were used to analyze the differential potential of serum VGF. Serum VGF levels were significantly lower in MDD patients but higher in BD patients compared with HC (both PTukey < 0.01). No correlation was found between serum VGF levels and any data of subjects. The optimal cutoff for serum VGF in discriminating BD patients from MDD patients was ≥1093.85 pg/ml (AUC = 0.990, sensitivity of 95%, specificity of 100% and accuracy of 95%). LRs further confirmed the differential efficiency of serum VGF in distinguishing BD and MDD patients with +LR of infinity and –LR of 0. The results suggest that serum VGF level changed significantly in MDD and BD patients and serum VGF may be an indicator for differentiating BD patients from MDD patients.
Uptake and remobilization of selenium in Brassica napus L. plants supplied with selenate or selenium‐enriched plant residues
Authors: Ebrahimi Nashmin , Hartikainen Helinä , Hajiboland Roghieh , Seppänen Mervi M. 
Published: December 2018

AbstractSelenium (Se) biofortification via crops is one of the best strategies to elevate the daily Se intake in areas where soil Se levels are low. However, Se fertilizer recovery (SeFR) is low and most of the Se taken up accumulates in non‐harvested plant parts and returns to the soil with plant residues. A pot experiment with soil was undertaken to study the efficiency of inorganic Se (Na2SeO4) and Se‐enriched plant residues for biofortification, as well as to identify the bottlenecks in Se utilization by Brassica napus L. The soil was fertilized with Na2SeO4 (0 and 7 µg Se kg−1) or with Se in stem or leaf residues (0 and 7 µg Se kg−1). A treatment with autoclaved soil was included (0 and 7 µg kg−1 as Na2SeO4) to unravel the impact of microbial activity on Se uptake. The Se‐enriched plant residues produced a lower Se uptake efficiency (SeUPE) and SeFR than did inorganic Se, and soil autoclaving enhanced Se accumulation in the plants. The time required for decomposition seems to preclude crop residues as an alternative source of Se. Furthermore, B. napus had a limited capacity to accumulate Se in seeds. The study shows that the bottlenecks in Se biofortification appear to be its low bioavailability in soil and poor loading from the silique walls to seeds. Thus, improved Se translocation to seeds would be a useful breeding goal in B. napus to increase SeFR.
Recovery of nutrients from the liquid fraction of digestate: Use of enriched zeolite and biochar as nitrogen fertilizers
Authors: Kocatürk-Schumacher Nazlı Pelin , Zwart Kor , Bruun Sander , Stoumann Jensen Lars , Sørensen Helle , Brussaard Lijbert 
Published: December 2018

AbstractThe liquid fraction after liquid/solid separation of biogas digestate has a high potential as a fertilizer due to its high nutrient concentration. However, the direct application of digestate in agricultural fields results in practical problems due to its voluminous nature. One solution to this could be to concentrate nutrients onto sorbents such as biochar or zeolites, which can subsequently be used as a fertilizer. This study investigated the ability of biochar and zeolite ‘clinoptilolite' enriched with digestate nutrients to supply nitrogen (N) when used as a fertilizer. A pot experiment with ryegrass was conducted to test the effect of a nutrient‐enriched biochar and clinoptilolite by determining plant biomass growth and N uptake. This included untreated biochar and clinoptilolite as controls and two levels of N application (15 and 45 mg N per pot) each at two initial loading ratios (low and high). Nutrient‐enriched biochar and clinoptilolite increased plant biomass yield (up to 1.02 and 2.39 g per pot) and N uptake (up to 11.23 and 39.94 mg N per pot) compared to the untreated sorbents treatments. Initial loading ratio had a significant effect on plant biomass response and apparent N recovery (ANR) for enriched clinoptilolite, and lower initial loading ratio improved plant growth. In contrast to clinoptilolite, higher initial loading ratio resulted in higher ANR. In conclusion, our results reveal that N released from enriched clinoptilolite and biochar could be taken up by the plants, clinoptilolite performed more effectively than biochar, and initial loading ratio affected the performance of the sorbents when used as a fertilizer.
Reflection and redesign of a residency program for the hospital pharmacist
Authors: Lui Viki H. , Toner Paul , Matthews Helen 
Published: December 2018

AbstractPrior to the Society of Hospital Pharmacists of Australia (SHPA) National Residency Program, residency training for pharmacists in Australia was not common practice. The Pharmacy Department at the Royal Melbourne Hospital has had a formalised residency program since 2004. More recently, a sustainability strategy was implemented to promote pharmacists who completed the residency program, which prompted a review of the existing program. A SWOT (strengths, weaknesses, opportunities and threats) analysis was undertaken, and a subsequent program was codeveloped with stakeholders and launched. The new residency program capitalised on the existing strengths and incorporated new elements from established US and UK residency standards, was implemented in May 2016, and was later awarded provisional accreditation by SHPA. The program has been shared with other organisations and was adopted by an interstate health network as a basis for their SHPA National Residency Program. The next phase of development will include an interim evaluation and initiatives to enhance the skill set of the team to deliver this program.
Overview of idelalisib for pharmacists
Authors: Rowan Gail D. , Carrington Christine V. , Siderov Jim 
Published: December 2018

AbstractIdelalisib is a potent oral selective inhibitor of phosphatidylinositol 3‐kinase p110δ. It is approved in Australia for the treatment of relapsed chronic lymphocytic leukaemia and small cell lymphocytic lymphoma in combination with rituximab or ofatumumab in patients for whom chemoimmunotherapy is not considered suitable. Idelalisib is reimbursed by the Australian Government for use in combination with rituximab. It is also approved and reimbursed for use as monotherapy in patients with follicular lymphoma refractory to at least two prior systemic therapies including rituximab and an alkylating agent. Idelalisib has demonstrated significant benefits in progression‐free survival and overall survival in these patient populations; however, patients receiving idelalisib require monitoring and education due to significant toxicities, particularly diarrhoea, infections and hepatotoxicity. There is also the potential for drug interactions resulting in toxicity or subtherapeutic treatment levels.
Deficits in Inhibitory Control May Place Service Members at Risk for Posttraumatic Stress Disorder and Negative Parenting Behavior Following Deployment‐Related Trauma
Authors: Monn Amy R. , Zhang Na , Gewirtz Abigail H. 
Published: December 2018

AbstractThis study examined the mediating role of posttraumatic stress disorder (PTSD) symptoms in the association between deployment‐related trauma exposure and parenting behaviors in reserve‐component military service members and whether this association was contingent upon parent inhibitory control (IC). Participants were 181 postdeployed fathers and their children. Fathers completed a neurospychological test of IC and self‐report measures of trauma exposure and PTSD symptoms. Measures of parenting behaviors (positive engagement and reactivity coercion) were obtained from direct observation of father–child interaction. Results demonstrated that (a) fathers’ PTSD symptoms indirectly mediated the effect of trauma exposure on both measures of parenting (i.e., negative indirect effect for positive engagement, point estimate = −.0045, 95% CI [−.0107, −.0003], and positive indirect effect for reactivity coercion, point estimate = .0061, 95% CI [.0007, .0146]); (b) fathers’ IC skills moderated the association between trauma exposure and PTSD, β = .14, p = .043, such that the association was positive and significant for fathers with high and medium IC but nonsignificant for fathers with low IC; and (c) the indirect effect of trauma exposure on both parenting measures through PTSD was dependent upon IC, point estimate = .0341, 95% CI [.0005, .0687]. These findings indicate that fathers with low IC skills tended to have higher rates of PTSD symptoms and related negative parenting behaviors, even for individuals with relatively low degrees of deployment‐related trauma exposure. Results highlight the importance of IC as a potential moderating factor in the association between trauma exposure, PTSD, and parenting.
Oral tongue squamous cell carcinoma survival as stratified by age and sex: A surveillance, epidemiology, and end results analysis
Authors: Mukdad Laith , Heineman Thomas E. , Alonso Jose , Badran Karam W. , Kuan Edward C. , St. John Maie A. 
Published: December 2018

Objectives/HypothesisTo utilize the Surveillance, Epidemiology, and End Results (SEER) database to elucidate differences in predictors of survival in oral tongue squamous cell carcinoma (OTSCC) as stratified by age and sex.Study DesignRetrospective, population‐based database analysis.MethodsThe SEER registry was utilized to calculate survival trends for patients with OTSCC between 1973 and 2012. Patient data were then stratified by age (≤40 years vs. >40 years) and sex, then analyzed with respect to race, stage, grade, and treatment modalities. Overall survival (OS) and disease‐specific survival (DSS) were calculated and compared.ResultsThere were 16,423 cases of OTSCC identified, with 526 and 706 young female and male patients, respectively. Young female patients had improved OS and DSS as compared to young male patients (75% vs. 67% at 5 years), which is better than older patients (P < .001). Younger patients were more likely to receive surgery (P < .001) and combination surgery and radiation (P < .001) as compared to older patients. On multivariate analysis, tumor stage was uniformly associated with worse OS and DSS (P < .05), with surgery predicting improved OS and DSS in all groups except young females (P < .05). Higher tumor grade predicted worse OS and DSS in older patients, but not younger patients (P < .05).ConclusionsOTSCC appears to present with relatively heterogeneous characteristics across different age groups and sexes. Despite the rising incidence of OTSCC in young individuals, our study demonstrates that young patients have improved survival rates compared to older patients.Level of EvidenceNALaryngoscope, 129:2076–2081, 2019
LipidomeDB Data Calculation Environment Has Been Updated to Process Direct‐Infusion Multiple Reaction Monitoring Data
Authors: Fruehan Carl , Johnson David , Welti Ruth 
Published: December 2018

AbstractLipidomeDB Data Calculation Environment (DCE), a web application for processing data from direct‐infusion tandem mass spectrometer data on lipids, was described by Zhou et al. (, Lipids, 46, 879‐884). The original version processed multiple precursor and/or neutral loss scans on multiple samples. A recent update to LipidomeDB DCE, http://lipidome.bcf.ku.edu:8080/Lipidomics/, extends LipidomeDB DCE's functionality to process data acquired in multiple reaction monitoring (MRM) mode by direct‐infusion mass spectrometry. Both the precursor‐neutral loss workflow and the MRM workflow remove signals due to isotopic overlap of lipid analytes and calculation of the amount of each target lipid in comparison with internal standards.
Impact of photodynamic therapy versus ultrasonic scaler on gingival health during treatment with orthodontic fixed appliances
Authors: Abellán Rosa , Gómez Clara , Iglesias‐Linares Alejandro , Palma Juan Carlos 
Published: December 2018

ObjectivesPoor oral hygiene during treatment with fixed appliances results in plaque accumulation. The presence of bacteria in the gingival crevice triggers an inflammatory reaction in the gingival tissues. The aim of this study was to compare the impact of two preventive treatments, photodynamic therapy (PDT), and ultrasonic scaler (US), on gingival health in patients under fixed orthodontic treatment.MethodsTwenty orthodontic patients were randomly allocated to two groups: PDT or US. Each group received seven sessions [days 0, 15, 30, 45, 90 (3‐months follow‐up), 180 (6‐months follow‐up), 270 (9‐months follow‐up)] of experimental interventions, and clinical parameters [Plaque index(PI); gingival index(GI); probing depth(PD)], periodontopathogens [Agreggatibacter actinomycetemcomitans; Porphyromonas gingivalis; Prevotella intermedia; Micromonas micros; Fusobacterium nucleatum; Tannerella forsythia; Campylobacter rectus; Eikenella corrodens; Capnocytopaga sp.] and protein markers [IL‐1β;IL‐1ra;IL‐6;IL‐10;TNF‐α;FGF‐2/FGF basic] were monitored at baseline and at 3, 6, and 9 months. ANOVA, Student's t‐test with Bonferroni correction and ANOVA with multiple rank test were used to identify differences between groups (P < 0.05).ResultsClinical assessments [PI, GI, and PD] yielded no differences (P > 0.05) between groups, which showed a major decrease at the start of the trial. Reductions in total colony forming units (log CFU reduction) were observed with both treatments, although to a greater extent in the PDT group, but with no differences between groups (P > 0.05). Similar reductions in log CFU counts of P. gingivalis, P. intermedia, and F. nucleatum were observed in both groups (P > 0.05). The two groups also showed similar trends for inflammatory mediators with decreased levels of IL‐1β, IL‐10, and TNF‐α, whereas IL‐6 and IL‐1ra levels remained stable and those of FGF‐2 were increased after both interventions, with no differences (P > 0.05) between groups.ConclusionBoth PDT and US methods proved similar effectiveness for the treatment of gingival inflammation induced by fixed orthodontic appliances. Lasers Surg. Med. 51:256–267, 2019. © 2018 Wiley Periodicals, Inc.
Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism
Authors: Barichella Michela , Severgnini Marco , Cilia Roberto , Cassani Erica , Bolliri Carlotta , Caronni Serena , Ferri Valentina , Cancello Raffaella , Ceccarani Camilla , Faierman Samanta , Pinelli Giovanna , De Bellis Gianluca , Zecca Luigi , Cereda Emanuele , Consolandi Clarissa , Pezzoli Gianni 
Published: December 2018

ABSTRACTBackgroundAlthough several studies have suggested that abnormalities in gut microbiota may play a critical role in the pathogenesis of PD, data are still extremely heterogeneous.Methods16S gene ribosomal RNA sequencing was performed on fecal samples of 350 individuals, subdivided into idiopathic PD (n = 193, of whom 39 were drug naïve) stratified by disease duration, PSP (n = 22), MSA (n = 22), and healthy controls (HC; n = 113). Several confounders were taken into account, including dietary habits.ResultsDespite the fact that unadjusted comparison of PD and HC showed several differences in relative taxa abundances, the significant results were greatly reduced after adjusting for confounders. Although most of these differences were associated with disease duration, lower abundance in Lachnospiraceae was the only difference between de novo PD and HC (remaining lower across almost all PD duration strata). Decreased Lachnospiraceae and increased Lactobacillaceae and Christensenellaceae were associated with a worse clinical profile, including higher frequencies of cognitive impairment, gait disturbances, and postural instability. When compared with HC, MSA and PSP patients shared the changes in PD, with a few exceptions: in MSA, Lachnospiraceae were not lower, and Prevotellaceae were reduced; in PSP, Lactobacillaceae were similar, and Streptococcaceae were reduced.ConclusionsGut microbiota may be an environmental modulator of the pathogenesis of PD and contribute to the interindividual variability of clinical features. Data are influenced by PD duration and several confounders that need to be taken into account in future studies. Prospective studies in de novo PD patients are needed to elucidate the net effect of dysbiosis on the progression of the disease. © 2018 International Parkinson and Movement Disorder Society