bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zeolitic Imidazolate Framework‐8 as pH‐Sensitive Nanocarrier for “Arsenic Trioxide” Drug Delivery
Authors: Ettlinger Romy , Moreno Natalia , Volkmer Dirk , Kerl Kornelius , Bunzen Hana 
Published: July 2019

AbstractPrevious results revealed that arsenic trioxide might be used as promising therapeutic agent for the treatment of some solid tumours as atypical teratoid rhabdoid tumours (ATRT). However, in order to become an approved drug for solid tumour treatment, the active formulation has to get more efficient and feasible—but at the same time less toxic. One of the possibilities to achieve this dichotomy is to use nanomedicine tools. Herein, we report on the Zn‐based metal–organic framework ZIF‐8 (Zeolitic Imidazolate Framework‐8) which turned out to be a promising candidate for the delivery of AsIII species. It conjointly features a high drug loading capacity and a prominent pH‐triggered release behaviour. AsIII‐loaded ZIF‐8 nanoparticles coated and non‐coated with polyethylene glycol were studied by XRPD, IR, Raman, TGA, TEM, EDX, CHN‐elemental analysis, sorption analysis and ICP‐OES, and their cytotoxicity was evaluated in vitro.
A semiparametric approach for modelling multivariate nonlinear time series
Authors: Samadi S. Yaser , Hajebi Mahtab , Farnoosh Rahman 
Published: July 2019

AbstractIn this article, a semiparametric time‐varying nonlinear vector autoregressive (NVAR) model is proposed to model nonlinear vector time series data. We consider a combination of parametric and nonparametric estimation approaches to estimate the NVAR function for both independent and dependent errors. We use the multivariate Taylor series expansion of the link function up to the second order which has a parametric framework as a representation of the nonlinear vector regression function. After the unknown parameters are estimated by the maximum likelihood estimation procedure, the obtained NVAR function is adjusted by a nonparametric diagonal matrix, where the proposed adjusted matrix is estimated by the nonparametric kernel estimator. The asymptotic consistency properties of the proposed estimators are established. Simulation studies are conducted to evaluate the performance of the proposed semiparametric method. A real data example on short‐run interest rates and long‐run interest rates of United States Treasury securities is analyzed to demonstrate the application of the proposed approach.The Canadian Journal of Statistics47: 668–687; 2019 © 2019 Statistical Society of Canada
Structure‐Guided Synthesis and Evaluation of Small‐Molecule Inhibitors Targeting Protein–Protein Interactions of BRCA1 tBRCT Domain
Authors: Kurdekar Vadiraj , Giridharan Saranya , Subbarao Jasti , Nijaguna Mamatha B. , Periasamy Jayaprakash , Boggaram Sanjana , Shivange Amol V. , Sadasivam Gayathri , Padigaru Muralidhara , Potluri Vijay , Venkitaraman Ashok R. , Bharatham Kavitha 
Published: July 2019

AbstractThe tandem BRCT domains (tBRCT) of BRCA1 engage phosphoserine‐containing motifs in target proteins to propagate intracellular signals initiated by DNA damage, thereby controlling cell cycle arrest and DNA repair. Recently, we identified Bractoppin, the first small‐molecule inhibitor of the BRCA1 tBRCT domain, which selectively interrupts BRCA1‐mediated cellular responses evoked by DNA damage. Here, we combine structure‐guided chemical elaboration, protein mutagenesis and cellular assays to define the structural features responsible for Bractoppin's activity. Bractoppin fails to bind mutant forms of BRCA1 tBRCT bearing K1702A, a key residue mediating phosphopeptide recognition, or F1662R or L1701K that adjoin the pSer‐recognition site. However, the M1775R mutation, which engages the Phe residue in the consensus phosphopeptide motif pSer‐X‐X‐Phe, does not affect Bractoppin binding, confirming a binding mode distinct from the substrate phosphopeptide binding. We explored these structural features through structure‐guided chemical elaboration and characterized structure–activity relationships (SARs) in biochemical assays. Two analogues, CCBT2088 and CCBT2103 were effective in abrogating BRCA1 foci formation and inhibiting G2 arrest induced by irradiation of cells. Collectively, our findings reveal structural features underlying the activity of a novel inhibitor of phosphopeptide recognition by the BRCA1 tBRCT domain, providing fresh insights to guide the development of inhibitors that target protein–protein interactions.
Highly Efficient and Selective Oxidation of Ethanol to Acetaldehyde by a Hybrid Photocatalyst Consisting of SnO2 Nanorod and Rutile TiO2 with Heteroepitaxial Junction
Authors: Awa Kenta , Akashi Ryo , Akita Atsunobu , Naya Shin‐ichi , Kobayashi Hisayoshi , Tada Hiroaki 
Published: July 2019

AbstractSingle‐crystal SnO2 nanorods were grown on rutile TiO2 with a heteroepitaxial relation of SnO2{001}/TiO2{001} (SnO2‐NR#TiO2) by a hydrothermal reaction. Resulting compressive lattice strain in the SnO2‐NR near the interface induces a continuous increase in the a‐axis length extending over 60 nm to relax towards the [001] direction from the root to the tip. UV‐light irradiation of the robust SnO2‐NR#TiO2 stably progresses the selective oxidation of ethanol to acetaldehyde with an external quantum yield of 25.6 % at excitation wavelength (λex)=365 nm under ambient temperature and pressure. Spectroscopic analyses and density functional theory simulation results suggested that the extremely high photocatalytic activity stems from the smooth interfacial electron transfer from TiO2 to SnO2‐NR through the high‐quality junction and subsequent efficient charge separation due to the lattice strain‐induced unidirectional potential gradient of the conduction band minimum in the SnO2‐NR.
Hydrogenation of Polyesters to Polyether Polyols
Authors: Stadler Bernhard M. , Hinze Sandra , Tin Sergey , de Vries Johannes G. 
Published: July 2019

AbstractThe amount of plastic waste is continuously increasing. Besides conventional recycling, one solution to deal with this problem could be to use this waste as a resource for novel materials. In this study, polyesters are hydrogenated to give polyether polyols by using in situ‐generated Ru‐Triphos catalysts in combination with Lewis acids. The choice of Lewis acid and its concentration relative to the ruthenium catalyst are found to determine the selectivity of the reaction. Monitoring of the molecular weight during the reaction confirms a sequential mechanism in which the diols that are formed by hydrogenation are etherified to the polyethers. To probe the applicability of this tandem hydrogenation etherification approach, a range of polyester substrates is investigated. The oligoether products that form in these reactions have the chain lengths that are appropriate for application in the adhesives and coatings industries. This strategy makes polyether polyols accessible that are otherwise difficult to obtain from conventional fossil‐based feedstocks.
OMIP‐060: 30‐Parameter Flow Cytometry Panel to Assess T Cell Effector Functions and Regulatory T Cells
Authors: Liechti Thomas , Roederer Mario 
Published: July 2019

AbstractWe developed this comprehensive 28‐color flow cytometry panel with the aim to measure a variety of T cell effector functions in combination with T cell differentiation markers (CCR7, CD27, CD28, CD45RO, CD95) in γδ T cells and CD4+ and CD8+ αβ T cells (Table 1). The effector functions measured in this panel include activation and co‐stimulatory molecules (CD69, CD137, and CD154), cytokines (IL‐2, IL‐13, IL‐17A, IL‐21, IL‐22, TNF, and IFNγ), the chemokine IL‐8, cytotoxic molecules (perforin and granzyme B), and the degranulation marker CD107a. In addition, Ki67 enables the identification and analysis of recently activated T cells. To characterize regulatory T cells (Tregs), we included CD25, CD39, and the canonical Tregs transcription factor FoxP3. We developed and optimized this panel for cryopreserved human peripheral blood mononuclear cells (PBMC) and stimulation with phorbol 12‐myristate 13‐acetate (PMA) and ionomycin. However, we successfully tested other types of stimulation such as staphylococcus enterotoxin B (SEB) or a mix of immunodominant peptides (CEF peptide pool) from cytomegalovirus (CMV), Epstein–Barr virus (EBV) and influenza. Published 2019. This article is a U.S. Government work and is in the public domain in the USA.
Usefulness of imprint cytology of gonadoblastoma with dysgerminoma in a patient with Turner syndrome and a Y chromosome: A case report and literature review
Authors: Nagai Tamiko , Hasegawa Kiyoshi , Motegi Emi , Machida Hiromi , Sasaki Hideo , Kato Hikaru , Kosaka Nobuaki , Fukasawa Ichio , Kuroda Hajime 
Published: July 2019

AbstractOvarian gonadoblastoma coexisting with a dysgerminoma is extremely rare in patients with Turner syndrome (TS) and a Y chromosome. The cytological findings, including imprint cytology, of these unusual ovarian tumors have rarely been reported. We report a rare patient with a gonadoblastoma with dysgerminoma, 3.0 × 2.0 cm in size; she was a 19‐year‐old woman with TS and a Y chromosome. She underwent laparoscopic bilateral gonadectomy, and the tumor was classified as stage IA (pT1aNxM0) according to the International Federation of Gynecology and Obstetrics classification system. Intraoperative imprint cytology revealed two types of neoplastic cells: small tumor cells surrounding light green‐stained or eosinophilic hyaline globules with marked calcification, suspicious for gonadoblastoma; and large, round, atypical cells with abundant cytoplasm, macronucleoli, and marked lymphocytic infiltration (two‐cell pattern), suspicious for dysgerminoma. The cytology results in our patient may represent the second reported results of imprint cytology describing a gonadoblastoma with dysgerminoma. They are the first reported results in a patient with TS and a Y chromosome.
Temperature‐mediated responses of carbon fluxes to precipitation variabilities in an alpine meadow ecosystem on the Tibetan Plateau
Authors: Chen Ning , Zhang Yangjian , Zhu Juntao , Zu Jiaxing , Huang Ke , Li Junxiang , Liu Yaojie , Cong Nan , Tang Ze , Wang Li , Zhu Yixuan 
Published: July 2019

AbstractEffects of climate warming and changing precipitation on ecosystem carbon fluxes have been intensively studied. However, how they co‐regulate carbon fluxes is still elusive for some understudied ecosystems. To fill the gap, we examined net ecosystem productivity (NEP), gross ecosystem productivity (GEP,) and ecosystem respiration (ER) responses to multilevel of temperature increments (control, warming 1, warming 2, warming 3, warming 4) in three contrasting hydrological growing seasons in a typical semiarid alpine meadow. We found that carbon fluxes responded to precipitation variations more strongly in low‐level warming treatments than in high‐level ones. The distinct responses were attributable to different soil water conditions and community composition under low‐level and high‐level warming during the three growing seasons. In addition, carbon fluxes were much more sensitive to decreased than to increased precipitation in low‐level warming treatments, but not in high‐level ones. At a regional scale, this negative asymmetry was further corroborated. This study reveals that future precipitation changes, particularly decreased precipitation would induce significant change in carbon fluxes, and the effect magnitude is regulated by climate warming size.
Panel quantile regressions for estimating and predicting the value‐at‐risk of commodities
Authors: Čech František , Baruník Jozef 
Published: July 2019

AbstractUsing a flexible panel quantile regression framework, we show how the future conditional quantiles of commodities returns depend on both ex post and ex ante uncertainty. Empirical analysis of the most liquid commodities covering main sectors, including energy, food, agriculture, and precious and industrial metals, reveal several important stylized facts. We document common patterns of the dependence between future quantile returns and ex post as well as ex ante volatilities. We further show that the conditional returns distribution is platykurtic. The approach can serve as a useful risk management tool for investors interested in commodity futures contracts.
Does Compassion Matter in Leadership? A Two‐Stage Sequential Equal Status Mixed Method Exploratory Study of Compassionate Leader Behavior and Connections to Performance in Human Resource Development
Authors: Shuck Brad , Alagaraja Meera , Immekus Jason , Cumberland Denise , Honeycutt‐Elliott Maryanne 
Published: July 2019

AbstractThe transformative power of compassion is critical to leader performance and has garnered increasing interest in business settings. Despite substantive contributions toward the conceptual understanding of compassion, prior empirical work on the relationship between compassion and leader performance is relatively limited. This article presents compassionate leader behavior as a conceptualization of a new leadership construct. A two‐stage, sequential, and equal status mixed method research design was utilized to develop and validate a measure of compassionate leadership. Study 1 used a phenomenological approach to understand how leaders engage with compassion and how their experiences and behaviors associated with compassion affect performance within the context of their leadership. Findings indicated that when leaders focused on compassionate behaviors during routine and focal events in the organization, six distinctive themes—integrity, empathy, accountability, authenticity, presence, and dignity—emerged as individual‐level building blocks of compassionate leadership behavior. In Study 2, we developed and validated a Compassionate Leader Behavior Index (CLBI) based on the six emergent behaviors and found general support for compassionate leadership for both practice and research. Implications of study findings and directions for future research in human resource development (HRD) are discussed.
Analysis of a boundary layer flow over moving an exponentially stretching surface with variable viscosity and Prandtl number
Authors: Govindaraj Nagarathinam , Singh Abhishek K. , Roy Satyajit , Shukla Pankaj 
Published: July 2019

AbstractBoundary layer flow phenomenons on a stretching sheet find numerous applications in industrial processes such as manufacture and extraction of rubber and polymer sheets. The current study focuses on two‐dimensional water boundary layer flow on exponential stretching surface with a vertical plate for variable physical properties of fluid such as viscosity and Prandtl number. The Quasilinearization technique has been used on governing equations to transform nonlinear to linear equations and these equations are discretized by finite difference techniques to get numerical solutions. The effect of buoyancy parameters (λ), velocity ratio parameter () and streamwise coordinator (ξ) on velocity profiles (F), temperature profiles (θ), local skin‐friction coefficient (Cfx(ReLξexp(ξ))1/2) and the local Nusselt number (Nux(ReLξexp(ξ))−1/2) has been analyzed graphically based on numerical outcome. The magnitude of velocity profiles increases and temperature profile decreases approximately by 4% and 16% with increases the buoyancy parameter from λ = 1 to λ = 3 at = 0.5 and ξ = 1.0. The skinfriction and heat transfer coefficient increases approximately by 22% and 27% with an increase in ξ from 0.5 to 1.0 at fixed  = 0.5 and λ = 1.0. The variations of velocity profiles and temperature profiles have more impact with as compared to ξ and λ. The benchmark studies were carried out to validate the current results with previously published work and found to be in excellent agreement.
Trauma, immigration, and sexual health among Latina women: Implications for maternal–child well‐being and reproductive justice
Authors: Fortuna Lisa R. , Noroña Carmen Rosa , Porche Michelle V. , Tillman Cathi , Patil Pratima A. , Wang Ye , Markle Sheri Lapatin , Alegría Margarita 
Published: July 2019

ABSTRACTLatina immigrant women are vulnerable to traumatic stress and sexual health disparities. Without autonomy over their reproductive health and related decision‐making, reproductive justice is elusive. We analyzed behavioral health data from 175 Latina immigrant participants (Mage = 35; range = 18–64) of the International Latino Research Partnership (ILRP) study. We used descriptive and inferential statistics to compare immigrant mothers of minor children to those without, regarding their psychological and reproductive health, and correlates of past exposure to sexual trauma. Over one third (38%) of ILRP participants had minor children, and 58% had citizenship in their host country. The rate for sexual assault was 30 and 61%, respectively, for physical assault; these rates were similarly high for women with and without minor children. Women who reported sexual assault scored significantly higher for depression, posttraumatic stress disorder, and substance‐abuse screens. Odds of experiencing sexual assault was highest for women who experienced physical assault (odds ratio = 10.74), and for those from the Northern Triangle (odds ratio = 8.41). Subgroups of Latina migrant mothers are vulnerable to traumatic stress and related sexual and mental health risks. Given these findings, we frame the implications in a reproductive justice framework and consider consequences for caregiver–child well‐being.
Avoidance of psychological pain and suicidal ideation in community samples: Replication across two countries and two languages
Authors: Campos Rui C. , Holden Ronald R. , Lambert Christine E. 
Published: July 2019

AbstractObjectivesA multidimensional psychological pain model of suicide has been developed that includes three dimensions: affective, cognitive, and avoidance. In the present research, we evaluated the relationships between the three dimensions of psychological pain and suicidal ideation.MethodTwo community samples from Portugal and the U.S. participated in the research.ResultsHierarchical multiple regression analysis demonstrated that when controlling for the effects of depressive symptoms and psychache, the avoidance dimension, but not the cognitive or affective dimension of psychological pain, explained significant, and unique variance in suicidal ideation in each sample.ConclusionEven when individuals perceive psychological pain, there may not be an elevated risk of suicide, provided that they do not consider suicide as a form of coping to decrease that pain.
Rac3, but not Rac1, promotes ox‐LDL induced endothelial dysfunction by downregulating autophagy
Authors: He Dan , Xu Ling , Wu Yuhang , Yuan Yuchan , Wang Ying , Liu Zhenzhu , Zhang Changlin , Xie Wenli , Zhang Lijiao , Geng Zhaohong , Wang Hongli , Wang Hongyan , Qu Peng 
Published: July 2019

AbstractThe endothelial dysfunction induced by oxidized low‐density lipoprotein (ox‐LDL) plays an important role in the pathogenesis of atherosclerosis, which can lead to oxidative stress and inflammation. The role of autophagy in the process of atherosclerosis has drawn increasing attention. The human umbilical vein endothelial cells (HUVECs), whose Ras‐related C3 botulinum toxin substrate 1 (Rac1) and Rac3 was knockdown, were used to detect whether the possible molecular mechanisms of Rac1 and Rac3 for anti‐inflammatory in endothelial cells was effected by downregulation of autophagy. The HUVECs were incubated with ox‐LDL. The inflammatory factors and autophagy proteins were evaluated to ascertain and compare the effect of Rac1 and Rac3 on autophagy. Then, 3‐methyladenine (3‐MA) as an inhibiter of autophagy was used to detect whether the effect of Rac1 and Rac3 was related to autophagy. ox‐LDL‐induced cell dysfunction in HUVECs was determined by testing the formation of foam cells, the expression of nuclear factor (NF)‐κB and nucleotide‐binding oligomerization domain (NOD)‐like receptor protein 3 and NF‐κB p65 and other inflammatory factors, the release of reactive oxygen species by oxidative stress and the dysfunction of the cytomembrane. And ApoE−/− mice on a high‐fat diet were used as an animal model to detect the effect of Rac1 and Rac3 in vivo. The results showed that when Rac1 and Rac3 were decreased in HUVECs, the cell dysfunction caused by ox‐LDL was inhibited. If 3‐MA was used to inhibit autophagy in Rac1 and Rac3 knockdown cells, the injury induced by ox‐LDL on the cells was recovered. These results indicated that the effect of Rac1 and Rac3 was combined with ox‐LDL, which was related to inhibition of autophagy. The effect of Rac3 was more significant than that of Rac1.
Long noncoding RNA FER1L4 acts as an oncogenic driver in human pan‐cancer
Authors: You Zilong , Ge Anqi , Pang Da , Zhao Yashuang , Xu Shouping 
Published: July 2019

AbstractThe function of Fer‐1 like family member 4 (FER1L4) in human pan‐cancer is unknown. Expression of FER1L4 in tumor tissues and nontumor tissues, upstream regulation of FER1L4, and the relationship between its expression with prognosis and chemoresistance were examined by The Cancer Genome Atlas and Gene Expression Omnibus databases. Next, these results were validated in breast tumor and paired nontumor tissues in our cohort. FER1L4 expression is higher in tumor tissues compared with the adjacent nontumor tissues. High FER1L4 expression is associated with worse disease outcomes. Hypomethylation and H3K4me3 accumulation in FER1L4 promoter locus activate its transcriptional expression. Moreover, FER1L4 may trigger chemoresistance in human cancer. Gene Ontology enrichment analysis revealed that FER1L4 may be involved in processes associated with tumorigenesis. These results indicated that FER1L4 may act as an oncogenic driver and it may be a potential therapy target in human cancer.
Exploring the impedance coverage limitation at current generate plane of transistors up to millimeter‐wave band based on comprehensive large signal model
Authors: Chen Yang , Xu Yuehang , Xu Ruimin 
Published: July 2019

AbstractThe harmonic power amplifiers (PAs) have potential to be used in the millimeter‐wave band, but the sophisticate parasitic network effects on the projection of reflection coefficient coverage from transistor package (TP) plane to current generator (CG) plane is an important challenge. In this work, every typical parasitic element with unique effect is derived theoretically. Thus, in the millimeter‐wave band, the reduced and rotated projection of parasitic network between the two planes becomes clear. The fundamental frequency (20 GHz), second harmonics (40 GHz), and third harmonics (60 GHz) load‐pull simulations using the commercial standard nonlinear transistor modeling are simulated. The simulation and derivation are consistent and show that output power and efficiency become less sensitive to harmonic tuning due to the lossy parasitic network. This work will be helpful for harmonic tuned transistor and PA design in the millimeter‐wave band, in the future.