bluuebunny/crossref_metadata_2025_split huggingface dataset:
Azithromycin treatment modifies airway and blood gene expression networks in neutrophilic COPD
Authors: Baines Katherine J. , Wright Thomas K. , Gibson Peter G. , Powell Heather , Hansbro Philip M. , Simpson Jodie L. 
Published: November 2018

Long-term, low-dose azithromycin reduces exacerbation frequency in chronic obstructive pulmonary disease (COPD), yet the mechanism remains unclear. This study characterised genome-wide gene expression changes in patients with neutrophilic COPD following long-term, low-dose azithromycin treatment.Patients with neutrophilic COPD (>61% or >162×104cells per mL sputum neutrophils) were randomised to receive either azithromycin or placebo for 12 weeks. Sputum and blood were obtained before and after 12 weeks of treatment. Gene expression was defined using microarrays. Networks were analysed using the Search Tool for the Retrieval of Interacting Gene database.In sputum, 403 genes were differentially expressed following azithromycin treatment (171 downregulated and 232 upregulated), and three following placebo treatment (one downregulated and two upregulated) compared to baseline (adjusted p<0.05 by paired t-test, fold-change >1.5). In blood, 138 genes were differentially expressed with azithromycin (121 downregulated and 17 upregulated), and zero with placebo compared to baseline (adjusted p<0.05 by paired t-test, fold-change >1.3). Network analysis revealed one key network in both sputum (14 genes) and blood (46 genes), involving interferon-stimulated genes, human leukocyte antigens and genes regulating T-cell responses.Long-term, low-dose azithromycin is associated with downregulation of genes regulating antigen presentation, interferon and T-cell responses, and numerous inflammatory pathways in the airways and blood of neutrophilic COPD patients.
Asthma severity and fertility outcome in women with polycystic ovary syndrome: a registry-based study
Authors: Zierau Louise , Cortes Rikke , Thomsen Simon Francis , Jimenez-Solem Espen , Lindenberg Svend , Backer Vibeke 
Published: November 2018

Recent research suggests that women with polycystic ovary syndrome (PCOS) have a higher risk of asthma. However, the severity of asthma, use of antiasthma medication and effect on fertility have yet to be investigated.In a case–control cross-sectional registry study using the Danish National Patient Register and other Danish registries, asthma prevalence, asthma severity, antiasthma medication use and fertility outcome were investigated among two groups of women with PCOS (n=1358 and n=17 123) and a healthy control group (n=5340).Both asthma prevalence (OR 1.45, 95% CI 1.24–1.70) and mean daily inhaled corticosteroid dose were higher among women with PCOS compared with healthy controls, whereas asthma severity was the same in women with and without PCOS. Women with PCOS and asthma had morein vitrofertilisation treatments than women in the control group with asthma, but the numbers of children per woman and spontaneous abortions were the same.Women with PCOS have a higher prevalence of asthma and a higher use of inhaled corticosteroids, whereas asthma severity is the same in women with and without PCOS. Asthma is associated with morein vitrofertilisation treatments in women with PCOS.
Exploring the genetic correlations of antisocial behaviour and life history traits
Authors: Tielbeek Jorim J. , Barnes J.C. , Popma Arne , Polderman Tinca J.C. , Lee James J. , Perry John R.B. , Posthuma Danielle , Boutwell Brian B. 
Published: November 2018

SummaryPrior evolutionary theory provided reason to suspect that measures of development and reproduction would be correlated with antisocial behaviours in human and non-human species. Behavioural genetics has revealed that most quantitative traits are heritable, suggesting that these phenotypic correlations may share genetic aetiologies. We use genome-wide association study data to estimate the genetic correlations between various measures of reproductive development (N = 52 776–318 863) and antisocial behaviour (N = 31 968). Our genetic correlation analyses demonstrate that alleles associated with higher reproductive output (number of children ever born, rg = 0.50, P = 0.0065) were positively correlated with alleles associated with antisocial behaviour, whereas alleles associated with more delayed reproductive onset (age at first birth, rg = −0.64, P = 0.0008) were negatively associated with alleles linked to antisocial behaviour. Ultimately, these findings coalesce with evolutionary theories suggesting that increased antisocial behaviours may partly represent a faster life history approach, which may be significantly calibrated by genes.Declaration of interestNone.
Loss of Zbtb32 in NOD mice does not significantly alter T cell responses.
Authors: Coley William D. , Zhao Yongge , Benck Charles J. , Liu Yi , Hotta-Iwamura Chie , Rahman M. Jubayer , Tarbell Kristin V 
Published: November 2018

Background:We previously identified the transcriptional regulator Zbtb32 as a factor that can promote T cell tolerance in the Non-Obese Diabetic (NOD) mouse, a model of Type 1 diabetes. Antigen targeted to DCIR2+dendritic cells (DCs)in vivoinhibited both diabetes and effector T cell expansion in NOD mice. Furthermore, Zbtb32 was preferentially induced in autoreactive CD4 T cells stimulated by these tolerogenic DCIR2+DCs, and overexpression of Zbtb32 in islet-specific T cells inhibited the diabetes development by limiting T cell proliferation and cytokine production.Methods:To further understand the role of Zbtb32 in T cell tolerance induction, we have now used CRISPR to target the Zbtb32 gene for deletion directly in NOD mice and characterized the mutant mice. We hypothesized that the systemic loss of Zbtb32 in NOD mice would lead to increased T cell activation and increased diabetes pathogenesis.Results:Although NOD.Zbtb32-/-male NOD mice showed a trend towards increased diabetes incidence compared to littermate controls, the difference was not significant. Furthermore, no significant alteration in lymphocyte number or function was observed. Importantly,in vitrostimulation of lymphocytes from NOD.Zbtb32-/-mice did not produce the expected hypersensitive phenotype observed in other genetic strains, potentially due to compensation by homologous genes.Conclusions:The loss of Zbtb32 in the NOD background does not result in the expected T cell activation phenotype.
Density artefacts at interfaces caused by multiple time-step effects in molecular dynamics simulations
Authors: Sidler Dominik , Lehner Marc , Frasch Simon , Cristófol-Clough Michael , Riniker Sereina 
Published: November 2018

Background:Molecular dynamics (MD) simulations have become an important tool to provide insight into molecular processes involving biomolecules such as proteins, DNA, carbohydrates and membranes. As these processes cover a wide range of time scales, multiple time-step integration methods are often employed to increase the speed of MD simulations. For example, in the twin-range (TR) scheme, the nonbonded forces within the long-range cutoff are split into a short-range contribution updated every time step (inner time step) and a less frequently updated mid-range contribution (outer time step). The presence of different time steps can, however, cause numerical artefacts.Methods:The effects of multiple time-step algorithms at interfaces between polar and apolar media are investigated with MD simulations. Such interfaces occur with biological membranes or proteins in solution.Results:In this work, it is shown that the TR splitting of the nonbonded forces leads to artificial density increases at interfaces. The presence of the observed artefacts was found to be independent of the interface shape and the thermostatting method used. It is further shown that integration with an impulse-wise reversible reference system propagation algorithm (RESPA) only shifts the occurrence of density artefacts towards larger outer time steps. Using a single-range (SR) treatment of the nonbonded interactions, on the other hand, resolves the density issue for pairlist-update periods of up to 40 fs.Conclusion:A SR scheme avoids numerical artefacts and offers an interesting alternative to TR RESPA with respect to performance optimization.
Group versus individual antenatal and first year postpartum care: Study protocol for a multi-country cluster randomized controlled trial in Kenya and Nigeria
Authors: Kabue Mark M. , Grenier Lindsay , Suhowatsky Stephanie , Oyetunji Jaiyeola , Ugwa Emmanuel , Onguti Brenda , Omanga Eunice , Gichangi Anthony , Wambua Jonesmus , Waka Charles , Enne Joseph , Don-Aki Jennyfer , Ali Mairo , Buba Maryam , Ang’aha Jenipher , Iya Daniel , Washika Elizabeth , Mohan Diwakar , Smith Jeffrey M. 
Published: November 2018

Background: Antenatal care (ANC) in many low- and middle-income countries is under-utilized and of sub-optimal quality. Group ANC (G-ANC) is an intervention designed to improve the experience and provision of ANC for groups of women (cohorts) at similar stages of pregnancy. Methods: A two-arm, two-phase, cluster randomized controlled trial (cRCT) (non-blinded) is being conducted in Kenya and Nigeria. Public health facilities were matched and randomized to either standard individual ANC (control) or G-ANC (intervention) prior to enrollment. Participants include pregnant women attending first ANC at gestational age <24 weeks, health care providers, and sub-national health managers. Enrollment ended in June 2017 for both countries. In the intervention arm, pregnant women are assigned to cohorts at first ANC visit and receive subsequent care together during five meetings facilitated by a health care provider (Phase 1). After birth, the same cohorts meet four times over 12 months with their babies (Phase 2). Data collection was performed through surveys, clinical data extraction, focus group discussions, and in-depth interviews. Phase 1 data collection ended in January 2018 and Phase 2 concludes in November 2018. Intention-to-treat analysis will be used to evaluate primary outcomes for Phases 1 and 2: health facility delivery and use of a modern method of family planning at 12 months postpartum, respectively. Data analysis and reporting of results will be consistent with norms for cRCTs. General estimating equation models that account for clustering will be employed for primary outcome analyzes. Results: Overall 1,075 and 1,013 pregnant women were enrolled in Nigeria and Kenya, respectively. Final study results will be available in February 2019. Conclusions: This is the first cRCT on G-ANC in Africa. It is among the first to examine the effects of continuing group care through the first year postpartum. Registration: Pan African Clinical Trials Registry PACTR201706002254227 May 02, 2017
Designing health information technology tools for behavioural health clinicians integrated within US-based primary care teams
Authors: Tate Woodson Tanisha , Gunn Rose , Clark Khaya D. , Balasubramanian Bijal A. , Jetelina Katelyn K. , Muller Brianna , Miller Benjamin F. , Burdick Timothy E. , Cohen Deborah J. 
Published: November 2018

BackgroundElectronic health records (EHRs) are a key tool for primary care practice. However, the EHR functionality is not keeping pace with the evolving informational and decision-support needs of behavioural health clinicians (BHCs) working on integrated teams.ObjectiveDescribe the workflows and tasks of integrated BHCs working with adult patients identify their health information technology (health IT) needs and develop EHR tools to address them.MethodA mixed-methods, comparative case study of six community health centres (CHCs) in Oregon, each with at least one BHC integrated into their primary care team. We observed clinical work and conducted interviews to understand workflows and clinical tasks, aiming to identify how effectively current EHRs supported integrated care delivery, including transitions, documentation, information sharing and decision-making. We analysed these data and employed a user-centred design process to develop EHR tools addressing the identified needs.ResultsBHCs used the primary care EHR for documentation and communication with other team members, but the EHR lacked the functionality to fully support integrated care. Needs include the ability to: (1) automate and track paper-based screening; (2) document behavioural health history; (3) access patient social and medical history relevant to behavioural health issues and (4) rapidly document and track progress on goals. To meet these needs, we engaged users and developed a set of EHR tools called the Behavioural Health e-Suite (BH e-Suite).ConclusionUS-based integrated primary care teams, and particularly BHCs working with adult populations, have unique information needs, workflows and tasks. These needs can be met and supported by the EHR with a moderate level of modification.
Ransom as Political Strategy: Captivity beyond Commercial Transaction on the Upper Guinea Coast in the Late Nineteenth and Early Twentieth Centuries
Authors: Carpenter Nathan 
Published: November 2018

Abstract
Histories of ransoming in West Africa have placed it alongside a host of related practices including pawning, panyarring, kidnapping, and enslavement, and firmly within histories of long-distance slave trading. This article considers how ransom functioned outside the conventional trans-Atlantic economic frameworks within which it is often placed by scholars. Drawing on cases from the Upper Guinea Coast, the article argues that hostage-taking for ransom was often a political act. Where political alliances were built and maintained through the exchange of people, ransom was a tool that could be employed to assert, maintain, or regain authority. Ransom reconsidered therefore offers important and overlooked evidence of the persistence of social and economic life in the shadow of macro-historical changes ushered in by transoceanic slave trading.
IMPLIKASI PERUBAHAN STATUS PENERIMA LISENSI TERHADAP PERJANJIAN LISENSI HAK CIPTA PADA ORGANISASI KSBSI
Authors: Irawati Irawati , Indrasrani Lailatussafa’ah 
Published: November 2018

Hak mutlak yang dimiliki manusia atas setiap hasil kreasi dari pikiran manusia disebut dengan hak cipta. Salah satu sengketa Hak Cipta yaitu kasus sengketa logo organisasi Konfederasi Serikat Buruh Sejahtera Indonesia (KSBSI) antara Muchtar Pakpahan melawan Rekson Silaban. Dalam perkembangannya organisasi mengalami pergantian bentuk. SBSI yang semula berbentuk Unitaris menjadi Konfederasi, hal tersebut disesuaikan dengan UU No. 21 Tahun 2000 tentang Serikat Pekerja/Buruh. Metode pendekatan yang digunakan dalam penelitian ini adalah metode pendekatan hukum yuridis normatif dengan menggunakan tipe deskriptif analisis yaitu menggambarkan peraturan perundang-undangan yang berlaku dikaitkan dengan teori hukum dan praktek pelaksanaan hukum positif yang menyangkut permasalahan .Sesuai dengan perkembangan hukum dalam Hak Cipta, maka terhadap Seni Logo yang digunakan sebagai Lambang Organisasi, telah dinyatakan tidak dapat dilakukan Pencatatan Ciptaan sebagaimana diatur dalam Pasal 65 Undang-Undang No. 28 tahun 2014 tentang Hak Cipta. Seharusnya sejak SBSI berubah status menjadi KSBSI harus ada perjanjian lisensi baru yang menyatakan bahwa KSBSI adalah organisasi terusan dari SBSI, Muchtar dan Rekson yang pada saat itu masih berada dalam satu payung organisasi juga seharusnya segera merubah AD/ART SBSI menjadi AD/ART KSBSI yang didalam juga dijelaskan sejarah pembentukan organisasi sampai perubahan status organisasi tersebut.Kata Kunci : Hak Cipta; Logo Organisasi; Perjanjian Lisensi; Perubahan Status.
Differential involvement of TAK1, RIPK1 and NF-κB signaling in Smac mimetic-induced cell death in breast cancer cells
Authors: Schmidt Nadine , Kowald Lisa , van Wijk Sjoerd J.L. , Fulda Simone 
Published: November 2018

Abstract
Smac mimetics (SMs) are considered promising cancer therapeutics. However, the mechanisms responsible for mediating cell death by SMs are still only partly understood. Therefore, in this study, we investigated signaling pathways upon treatment with the bivalent SM BV6 using two SM-sensitive breast cancer cell lines as models. Interestingly, genetic silencing of transforming growth factor (TGF)β activated kinase (TAK)1, an upstream activator of the nuclear factor-kappaB (NF-κB) subunit RelA (p65), increased BV6-induced cell death only in EVSA-T cells, although it reduced BV6-mediated upregulation of tumor necrosis factor (TNF)α in both EVSA-T and MDA-MB-231 cells. By comparison, genetic silencing of p65, a key component of canonical NF-κB signaling, blocked BV6-induced cell death in MDA-MB-231 but not in EVSA-T cells. Similarly, knockdown of NF-κB-inducing kinase (NIK) rescued MDA-MB-231 cells from BV6-induced cell death, while it failed to do so in EVSA-T cells. Consistently, silencing of p65 or NIK reduced BV6-stimulated upregulation of TNFα in MDA-MB-231 cells. In conclusion, TAK1, receptor-interacting kinase 1 (RIPK1) as well as canonical and non-canonical NF-κB signaling are differentially involved in SM-induced cell death in breast cancer cells. These findings contribute to a better understanding of SM-induced signaling pathways.
ОПИТУВАЛЬНИК «БАГАТОВИМІРНА ШКАЛА ПЕРФЕКЦІОНІЗМУ» П. ГЕВІТТА ТА Г. ФЛЕТТА: ПРОЦЕС ТА РЕЗУЛЬТАТИ АДАПТАЦІЇ
Authors: Целюк Тетяна 
Published: November 2018

У статті здійснено ґрунтовний огляд наукових джерел, який відтворює основні теоретичні уявлення про перфекціонізм у зарубіжній психології, починаючи з перших теоретичних напрацювань M. Hollender та W. Missildine і закінчуючи сучасними дослідженнями описаного феномену. Розглянуто дві основні моделі перфекціонізму: одновимірну та багатовимірну (американська, канадська та британська версії). Зосереджено увагу на багатовимірній канадській моделі перфекціонізму G. Flett та P. Hewitt, у рамках якої перфекціонізм набуває трьох різних форм: «я-орієнтований» перфекціонізм (selforiented perfectionism), перфекціонізм, орієнтований на інших (socially oriented perfectionism) і «соціально- приписуваний» перфекціонізм (socially pre-scripted perfectionism). Крім зарубіжних підходів, розглянуто погляди українських та російських психологів на досліджуваний феномен. У роботі здійснено опис історії розробки оригінального варіанту методики «Багатовимірна шкала перфекціонізму». Представлено процес та результати адаптації україномовного варіанту даного тесту (здійснення адаптованого перекладу, формування вибірки, проведення тестування респондентів, обробка отриманих даних), а також перевірки основних психодіагностичних критеріїв методики, таких як надійність, валідність та дискримінативність за допомогою спеціалізованого програмного забезпечення для психологічних досліджень.. Здійснено прогнозування щодо майбутніх досліджень у цій сфері
The article reviews the scientific sources, which showed the basic theoretical ideas about perfectionism in foreign psychology starting with the first theoretical work of M. Hollender and W. Missildine, and whining the modern researches of the described phenomenon. It was reviewed the two main models of perfectionism: one- dimensional and m ultidimensional (American, Canadian and British versions). The focus is on the Canadian model of perfectionism, G. Flett, P. Hewitt, in which perfectionism takes three different forms: focused on themselves (self- oriented perfectionism), focused on the other (socially oriented perfectionism) on the projection environment itself (socially pre-scripted perfectionism). We consider the views of perfectionism Ukrainian and Russian psychologists. In this paper, we described the history of creating the original version of the test "Multidimensional Perfectionism Scale". The process and results of the adaptation of the Ukrainian-language version of the test are presented (implementation of adapted translation, sample formation, testing of respondents, processing of the received data, the basic psychodiagnostic criteria of the method (reliability, validity, discriminativeness) are checked. with the help of specialized software for psychological research, are presented. There are also forecasts for future research in this area.
РЕЛІГІЙНІ ОРІЄНТАЦІЇ ОСОБИСТОСТІ У СТРУКТУРІ ЇЇ РЕЛІГІЙНОЇ СВІДОМОСТІ ТА РЕЛІГІЙНОГО ДОСВІДУ
Authors: Мельник Юлія 
Published: November 2018

У статті досліджується актуальна проблема індивідуального ставлення людини до релігійних орієнтацій в аспекті методології особистісного підходу. Аналізуються основні чинники розвитку релігійних орієнтацій особистості.
Описуються й узагальнюються результати теоретичного дослідження, базою для якого слугували праці відомих науковців. Здійснюється порівняльний аналіз трьох груп із різним типом релігійної орієнтації: ті, які тяжіють до внутрішньої релігійності, «змішаний» тип релігійності та люди із зовнішньою релігійністю; виокремлено низку чинників, що впливають на релігійні орієнтації особистості: сам феномен релігійності, релігійна свідомість, релігійний досвід, релігійні цінності, релігійні переживання тощо. Кожен із перелічених чинників здійснює специфічний вплив на індивіда, в наслідок чого формується цілісна релігійна орієнтація (ставлення індивіда до релігії як у теоретичному розумінні, так і в практичному застосуванні).
The article deals with the actual problem of individual attitude of a person to religious orientations in the aspect of methodology of personality approach. The main factors of the development of religious orientations of the personality.
Described and summarized the results of theoretical research, based on the works of the popular scholars. The comparative analysis of three groups with different types of religious orientation is given: those who tend to internal religiosity, «mixed» type of religiosity and people with external religiosity. Identified a number of factors that influence the religious orientation of the individual: the very phenomenon of religiosity, consciousness, religious experience, religious values, religious affects, etc. Each of the above factors has its influence, and as a result, forms a holistic religious orientation (the attitude of the individual to religion both in the theoretical sense and in practical application).