bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping schistosomiasis risk landscapes and implications for disease control: A case study for low endemic areas in the Middle Paranapanema river basin, São Paulo, Brazil
Authors: Ferreira da Silva Vivian Alessandra , Kampel Milton , Silva dos Anjos Rafael , Gardini Sanches Palasio Raquel , Escada Maria Isabel Sobral , Tuan Roseli , Singleton Alyson , Glidden Caroline Kate , Chamberlin Andrew , De Leo Giulio Alessandro , Pinter dos Santos Adriano , Vieira Monteiro Antônio Miguel 
Published: November 2024

Background
Schistosomiasis, a chronic parasitic disease, remains a public health issue in tropical and subtropical regions, especially in low and moderate-income countries lacking assured access to safe water and proper sanitation. A national prevalence survey carried out by the Brazilian Ministry of Health from 2011 to 2015 found a decrease in human infection rates to 1%, with 19 out of 26 states still classified as endemic areas. There is a risk of schistosomiasis reemerging as a public health concern in low-endemic regions. This study proposes an integrated landscape-based approach to aid surveillance and control strategies for schistosomiasis in low-endemic areas.

Methodology/Principal findings
In the Middle Paranapanema river basin, specific landscapes linked to schistosomiasis were identified using a comprehensive methodology. This approach merged remote sensing, environmental, socioeconomic, epidemiological, and malacological data. A team of experts identified ten distinct landscape categories associated with varying levels of schistosomiasis transmission potential. These categories were used to train a supervised classification machine learning algorithm, resulting in a 92.5% overall accuracy and a 6.5% classification error. Evaluation revealed that 74.6% of collected snails from water collections in five key municipalities within the basin belonged to landscape types with higher potential for S. mansoni infection. Landscape connectivity metrics were also analysed.

Conclusions/Significance
This study highlights the role of integrated landscape-based analyses in informing strategies for eliminating schistosomiasis. The methodology has produced new schistosomiasis risk maps covering the entire basin. The region’s low endemicity can be partly explained by the limited connectivity among grouped landscape-units more prone to triggering schistosomiasis transmission. Nevertheless, changes in social, economic, and environmental landscapes, especially those linked to the rising pace of incomplete urbanization processes in the region, have the potential to increase risk of schistosomiasis transmission. This study will help target interventions to bring the region closer to schistosomiasis elimination.
Adaptation of the G-NORM (Gender norms scale) in Uganda: An examination of how gender norms are associated with reproductive health decision-making
Authors: Sedlander Erica , Granovsky Rachel , Birabwa Catherine , Amongin Dinah , Wasswa Ronald , Diamond-Smith Nadia , Waiswa Peter , Holt Kelsey , Bingenheimer Jeffrey B. 
Published: November 2024

Background
Restrictive gender norms exacerbate health inequalities all over the world. More specifically, they prevent women from seeking preventive health services, constrain women’s economic empowerment, and are associated with reproductive health decision making. Gender norms, a subset of social norms, are dynamic and change over time. However, we lack data on how they are changing and how these changes affect health outcomes because current measures do not adequately capture the complex concept of gender norms.

Methods
We originally developed and validated a gender norms scale, the G-NORM, in India. In this study, using cross-sectional data, we adapted the G-NORM from Southeast Asia (India and Nepal) to sub-Saharan Africa (Uganda) in four steps: 1. Formulation of new scale items (via qualitative analysis) 2. Cognitive Interviewing 3. Questionnaire Administration (n = 2422 women of reproductive age) and 4. Psychometric analysis (Confirmatory Factor Analysis).

Results
Like the original scale, descriptive norms and injunctive norms comprised two unique sub scales with high Cronbach’s alphas (.80 & .92). Average scores differed depending on the type of norm suggesting that some gender norms are changing faster than others. Specifically, more equitable injunctive norms were associated with lower odds of partner-dominated contraceptive decision making but descriptive norms were not.

Conclusions
Gender norms serve as a multi-faceted determinant of health and wellbeing and require measurement tools which account for their conceptual complexity. Validating the G-NORM in Uganda expands measurement options for researchers in the sub-Saharan African region working to change norms to reduce health inequalities or to understand the gender normative context before beginning a study.
Effects of gestational age on blood cortisol and prolactin levels during pregnancy in malaria endemic area
Authors: Kiemde Francois , Sorgho Hermann , Zango Serge Henri , Some Gnohion Fabrice , Rouamba Toussaint , Traore Ousmane , Kabore Berenger , Natama Hamtandi Magloire , Hien Yeri Esther , Valea Innocent , Schallig Henk , Tinto Halidou 
Published: November 2024

Background
The hormonal shift occurring in pregnant women is crucial for the outcome of pregnancy. We conducted a study in pregnant women living in a malaria endemic area to determine the potential effect of gestational age on the modulation of the endocrine system by cortisol and prolactin production during pregnancy.

Methods
Primigravidae and multigravidae with a gestational age between 16–20 weeks were included in the study and followed up to delivery and 6–7 weeks thereafter. Venous blood was collected at scheduled visit: Visit 1 (V1; 16–20 weeks of amenorrhea), Visit 2 (V2; 28 ±1 weeks of pregnancy), Visit 3 (V3; 32 ±1 weeks of pregnancy), Visit4 (V4; delivery) and Visit5 (V5; 6–7 weeks after delivery). In addition, a cord blood sample was also collected during labour at delivery. Nulliparous and primiparous/multiparous non-pregnant women were enrolled in the control group. Cortisol and prolactin plasma concentrations were measured using ichroma II and i-chamber apparatus. Light microscopy was used to detect Plasmodium falciparum infections. A linear mixed-effects regression (LMER) model was used to assess the association between the variation of cortisol titres and prolactin levels during the pregnancy and the post-partum.

Results
Results showed that cortisol and prolactin levels in the peripheral blood were globally up-regulated during pregnancy. Concentrations of cortisol during follow-up was significantly higher in primigravidae than in multigravidae during the whole pregnancy (p<0.024). Moreover, the level of prolactin which was higher before delivery in primigravidae reversed at delivery and postpartum visit, but the difference was not statistically significant during the follow-up (V1 to V5) (p = 0.60). The cortisol level in peripheral blood at delivery was higher than that in the cord blood, and conversely for prolactin. Cortisol and prolactin levels decreased after delivery, though the level of prolactin was still higher than that at enrolment. An increase of one unit of prolactin was associated with the decrease of the average concentration of cortisol by 0.04 ng/ml (p = 0.009). However, when cortisol increases with one unit, the average concentration of prolactin decreases by 1.16 ng/ml (p = 0.013).

Conclusion
These results showed that the up-regulation effects of cortisol and prolactin are related to gestational age. A The downward regulation effect that both hormones have on each other during the pregnancy when each increase to 1 unit (1.0 ng/ml) was also reported.
Modelos de Trabalho: Impactos na performance e na qualidade de vida dos profissionais da área de Tecnologia da Informação
Authors: Uchôa João Gabriel Abrantes de Oliveira , Medeiros Elyskarien Ferreira Rosendo , Landim Jose Marcondes Macedo , Oliveira Gislene Farias de 
Published: November 2024

A performance e a qualidade de vida dos funcionários de qualquer empresa ou organização são aspectos de grande importância para todas as entidades envolvidas, visto que é necessário equilíbrio entre ambas as partes para possibilitar uma relação empregatícia saudável e eficiente. Assim, uma das maneiras que as empresas podem manipular a forma de trabalho dos seus empregados consiste no estabelecimento de modelos de trabalho que os funcionários devem seguir, sendo esses o presencial, remoto e híbrido, cada um com características e impactos distintos na performance e qualidade de vida. Com base nisso, este trabalho buscou analisar os impactos dos modelos de trabalho na performance e na qualidade de vida dos funcionários da área de Tecnologia da Informação. Do ponto de vista metodológico, foi realizada uma pesquisa Survey cujos dados foram coletados através da aplicação de um questionário. Com base nas respostas obtidas, foi realizado um tratamento estatístico através do qual foram feitos testes de hipótese para verificar o impacto do modelo de trabalho remoto em relação aos outros. Por fim, concluiu-se que o modelo de trabalho remoto, com base nos dados colhidos, apresenta bons indícios de que contribui positivamente para a performance e qualidade de vida. Ademais, constatou-se também que o modelo de trabalho remoto apresenta indícios significativos do impacto positivo na qualidade em relação aos outros modelos, entretanto, não existem evidências suficientes para constatar que essa declaração seja verdadeira para a performance.
Aprendizagem com a utilização de Simuladores Cirúrgicos e Virtuais no Ensino da Saúde: Uma Revisão Sistemática
Authors: Araújo Mikaely Medeiros de , Silva Lucas Lucena Medeiros da , Medeiros Fernanda Augusta de Andrade , Silva Ana Karoliny de Valença , Medeiros Nara Maria Holanda de , Almeida Elzenir Pereira de Oliveira 
Published: November 2024

A simulação na educação em saúde oferece uma abordagem interdisciplinar para preparar alunos para ambientes médicos. A simulação proporciona uma imersão eficaz em cenários clínicos e aprimora competências antes do contato com pacientes reais. O objetivo desse trabalho é demonstrar a importância da utilização de métodos de simulação em saúde, para os alunos que buscam a aprendizagem e melhorias nas técnicas utilizadas em suas futuras áreas de atuação. Trata-se de uma revisão sistemática da literatura, realizada através de buscas nas bases de dados Sciencedirect, Scopus, Web of science e Google Acadêmico. Como critérios de inclusão foram considerados os trabalhos publicados nos últimos 03 anos nos idiomas inglês e português, o uso de simulador cirúrgico na pratica de ensino da saúde e trabalhos que avaliaram o desempenho dos alunos que utilizaram os simuladores. A simulação médica e as tecnologias inovadoras estão sendo amplamente adotadas na formação médica e cirúrgica. O uso de videogames, simuladores laparoscópicos, realidade virtual e estendida, modelos 3D e impressões 3D são ferramentas eficazes para o desenvolvimento de habilidades e conhecimentos dos alunos, proporcionando experiências em ambientes otimizados pela tecnologia. A telessimulação facilita a educação em saúde de forma remota, promovendo interação e desenvolvimento profissional. A simulação no ensino da saúde é um método de ensino ativo e inovador, que apresenta modelos eficientes de treinamentos físicos ou virtuais que agregam de forma significativa na aprendizagem dos alunos e preparam profissionais da saúde para lidar com desafios da vida real de forma mais segura e eficaz.
A Importância das Equipes Interdisciplinares nos Centros de Atenção Psicossocial (CAPS)
Authors: Fernandes Fernando França , Silva Elizabeth Alves , Bezerra Martha Maria Macedo 
Published: November 2024

O trabalho realizado pelas equipes interdisciplinares nos Centros de Atenção Psicossocial (CAPS) envolve uma abordagem colaborativa e integrada para oferecer cuidados de saúde mental. Esses profissionais, vindos de diferentes áreas como psicologia, psiquiatria, enfermagem, assistência social, entre outras, unem seus conhecimentos e experiências para criar estratégias de tratamento personalizadas e humanizadas, que atendam às necessidades específicas de cada pessoa em sofrimento psíquico. O objetivo do presente estudo foi analisar a importância do trabalho das equipes interdisciplinares, atuantes em um CAPS no Sul do Ceará. Contou com a participação de 23 profissionais de diferentes CAPS (CAPSad, CAPSi e CAPS III) em um município do Sul do Ceará. Foi realizada entre maio de 2022 e abril de 2024. Para coletar os dados, foram utilizadas técnicas como observação e encontros de discussão sobre o trabalho. Os resultados levaram a crer que a atuação em equipe facilita a troca de saberes, enriquecendo o cuidado e garantindo uma atenção mais ampla e efetiva ao paciente, sempre com o foco em sua recuperação e reintegração social. Conclusão: A dimensão coletiva do trabalho interdisciplinar contribui significativamente para uma gestão mais eficiente das atividades. No entanto, é essencial que os coletivos de trabalho sejam fortalecidos, com a criação de espaços grupais mais efetivos para discussão, troca de ideias e colaboração. Isso favorece a construção de uma equipe mais coesa e preparada para enfrentar os desafios do dia a dia.
Medical Insurance Contribution and Firm-Level Total Factor Productivity
Authors: Huang Tao , Sun Rui , Zhao Zhe 
Published: November 2024

Abstract
This paper investigates the relation between medical insurance contribution and firm-level total factor productivity in China. Using a sample of Chinese A-share companies from 2007 to 2022, we find robust evidence that firms exhibit lower total factor productivity when medical insurance contribution is increasing. Specifically, we also show that this negative effect is more profound for state-owned enterprises, enterprises with lower employee compensation, and labor-intensive enterprises. Meanwhile, our findings remain valid after a series of robustness tests and controlling for endogeneity. Finally, we propose that the decreasing employees’ disposable income is plausible channel through which medical insurance contribution discourages firm-level total factor productivity in China. Overall, these results shed light on the real effects of medical insurance contribution and the determinants of firm-level total factor productivity.
Cross Ownership Under Strategic Tax Policy
Authors: Can Gökhan , Mukherjee Arijit 
Published: November 2024

Abstract
We provide a new reason for the consumer surplus and welfare raising cross ownership. We show that cross ownership reduces the tax rate, and increases consumer surplus and welfare under Cournot and Bertrand competition when the marginal social cost/benefit of public funds is less than unity. We further show that Cournot competition creates higher consumer surplus and welfare compared to Bertrand competition if the marginal social cost/benefit of public funds is less than unity, thus providing a new reason for the Cournot-Bertrand welfare reversal.
Roseolithon mirabile (Foslie) comb. nov. (Hapalidiales, Corallinophycidae, Rhodophyta) based on DNA sequencing of the Archaeolithothamnion mirabile lectotype
Authors: Gabrielson Paul W. , Lamb Jeremy J. , Hughey Jeffery R. 
Published: November 2024

Abstract

Lithothamnion
mirabile is currently considered a heterotypic synonym of L. muelleri. Three of the 14 specimens and additional fragments comprising the holotype of L. mirabile were selected for DNA sequencing as they best matched the protologue. The three 263-base pair rbcL sequences were distinct from each other, and were classified in the order Hapalidiales, but none were resolved in Lithothamnion. One sequenced specimen belongs in Roseolithon and was selected as the lectotype; thus we propose R. mirabile (Foslie) comb. nov. Another sequenced specimen groups with Phymatolithopsis and the third is well resolved in an undescribed genus of Hapalidiales sister to Boreolithothamnion.
Stochastic dissipative Euler’s equations for a free body
Authors: de la Torre Jaime Arturo , Sánchez-Rodríguez Jesús , Español Pep 
Published: November 2024

Abstract
Intrinsic thermal fluctuations within a real solid challenge the rigid body assumption that is central to Euler’s equations for the motion of a free body. Recently, we have introduced a dissipative and stochastic version of Euler’s equations in a thermodynamically consistent way (European Journal of Mechanics – A/Solids 103, 105,184 (2024)). This framework describes the evolution of both orientation and shape of a free body, incorporating internal thermal fluctuations and their concomitant dissipative mechanisms. In the present work, we demonstrate that, in the absence of angular momentum, the theory predicts that the principal axes unit vectors of a body undergo an anisotropic Brownian motion on the unit sphere, with the anisotropy arising from the body’s varying moments of inertia. The resulting equilibrium time correlation function of the principal eigenvectors decays exponentially. This theoretical prediction is confirmed in molecular dynamics simulations of small bodies. The comparison of theory and equilibrium MD simulations allow us to measure the orientational diffusion tensor. We then use this information in the Stochastic Dissipative Euler’s Equations, to describe a non-equilibrium situation of a body spinning around the unstable intermediate axis. The agreement between theory and simulations is excellent, offering a validation of the theoretical framework.
VS-LTGARCHX: A Flexible Variable Selection in Log-TGARCHX Models
Authors: Orujov Samir , Elvira Victor , Poterie Audrey , Rajabov Farid , Septier Francois 
Published: November 2024

Abstract
The log-TGARCHX model is less restrictive in terms of the inclusion of exogenous variables and asymmetry lags compared to the GARCHX model. Nevertheless, adding less (or more) covariates than necessary may lead to under- or overfitting, respectively. In this context, we propose a new algorithm, called VS-LTGARCHX, which incorporates a variable selection procedure into the log-TGARCHX estimation process. Furthermore, the VS-LTGARCHX algorithm is applied to extremely volatile BTC markets using 42 conditioning variables. Interestingly, our results show that the VS-LTGARCHX models outperform benchmark models, namely the log-GARCH(1,1) and log-TGARCHX(1,1) models, in one-step-ahead forecasting.
High-throughput sequencing reveals twelve cell death pattern prognostic target genes as potential drug-response-associated genes in the treatment of colorectal cancer cells with palmatine hydrochloride
Authors: Luo Sha , Xu Jiajun , Mo Chune , Gong Weiwei , Li Chunhong , Hou Xianliang , Ou Minglin 
Published: November 2024

Abstract

Objectives
Palmatine Hydrochloride (PaH), an isoquinoline alkaloid from Phellodendron amurense and Coptis chinensis, has analgesic, anti-inflammatory, and anticancer properties. This study aimed to assess PaH’s effectiveness against SW480 colorectal cancer (CRC) cells and explore its molecular mechanisms.

Methods
PaH’s effects on SW480 CRC cells were evaluated using MTT assays for proliferation, scratch assays for migration, and flow cytometry for apoptosis. Differentially expressed genes (DEGs) were identified through high-throughput sequencing. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses assessed DEG roles. Prognostic significance related to programmed cell death (PCD) was analyzed using R-Package with TCGA data. RT-qPCR validated key genes identified.

Results
PaH significantly inhibited SW480 cell growth, invasion, and apoptosis. The MTT assay showed inhibition rates increased from 5.49 % at 25 μg/mL to 52.48 % at 400 μg/mL. Scratch assays indicated reduced cell invasion over 24, 48, and 72 h. Apoptosis rose from 12.36 % in controls to 45.54 % at 400 μg/mL. Sequencing identified 3,385 significant DEGs, primarily in cancer pathways (p=0.004). Among 35 PCD-related DEGs, Lasso Cox regression highlighted 12 key genes, including TERT, TGFBR1, WNT4, and TP53. RT-qPCR confirmed TERT and TGFBR1 downregulation (0.614-fold, p=0.008; 0.41-fold, p<0.001) and TP53 and WNT4 upregulation (5.634-fold, p<0.001; 5.124-fold, p=0.002).

Conclusions
PaH inhibits CRC cell proliferation, migration, and invasion by modulating key PCD genes, suggesting its potential as a CRC therapeutic agent.
Combined Nabpaclitaxel pressurized intraPeritoneal aerosol chemotherapy with systemic Nabpaclitaxel-Gemcitabine chemotherapy for pancreatic cancer peritoneal metastases: protocol of single-arm, open-label, phase II trial (Nab-PIPAC trial)
Authors: Di Giorgio Andrea , Ferracci Federica , Bagalà Cinzia , Carbone Carmine , Salvatore Lisa , Strippoli Antonia , Attalla El Halabieh Miriam , Abatini Carlo , Alfieri Sergio , Pacelli Fabio , Tortora Giampaolo 
Published: November 2024

Abstract

Objectives
Current therapies show limited efficacy against peritoneal metastases (PM) from pancreatic cancer. Pressurized intra-peritoneal aerosol chemotherapy (PIPAC) has emerged as a novel intraperitoneal drug delivery method. Recently, a dose-escalation study identified the safe dose of Nabpaclitaxel for PIPAC administration, an ideal intraperitoneal chemotherapy agent against pancreatic cancer. Combining systemic NabPaclitaxel-Gemcitabine with NabPaclitaxel-PIPAC may enhance disease control in pancreatic cancer patients with PM.

Methods
The Nab-PIPAC trial is a single-center, prospective, open-label, phase II study (ClinicalTrials.gov identifier: NCT05371223). Its primary goal is to evaluate the antitumor activity of the combined treatment based on Disease Control Rate (DCR) using RECISTv.1.1 criteria. Secondary objectives include feasibility, safety, pathological response, progression-free and overall survival, nutritional status, quality of life, pharmacokinetics of NabPaclitaxel-PIPAC, and PM molecular evolution via translational research. The treatment protocol consists of three courses, each with two cycles of intravenous NabPaclitaxel-Gemcitabine and one cycle of NabPaclitaxel-PIPAC, with standard metastatic pancreatic cancer doses for the former and 112.5 mg/m2 for the latter. Sample size follows Simon’s two-stage design: 12 patients in stage one and 26 in stage two (80 % power, 0.1 alpha).

Results
Partial results will be available after first stage enrollment.

Conclusions
This trial aims to determine the antitumor efficacy and safety of combining NabPaclitaxel-PIPAC with systemic NabPaclitaxel-Gemcitabine in pancreatic cancer patients with PM.
Forced stability studies and estimation of encapsulated ellagic acid in nano-formulations using UV-spectroscopy
Authors: Kumar Suraj , Khairnar Yogesh , Karmakar Arka , Kumar Lalit 
Published: November 2024

Abstract
There is a growing interest in dietary materials to explore their therapeutic activities. Ellagic acid is considered as a dietary supplement and is naturally present in fruits and other foods. It has anticancer, antimalarial, antiviral, antioxidant, and anti-inflammatory activities. These activities can be enhanced with nanoformulations, which can increase its oral bioavailability. However, there is a need for an economical, simple, sensitive, and robust analytical method for the estimation of entrapped ellagic acid in the nanoformulations. Therefore, the present study presents the development and validation of a UV–visible spectroscopy method for the estimation of EA in nanoformulations. The phosphate buffer (pH 7.2) and the detection wavelength of 253.5 nm were used for the method development, and its validation was performed according to the ICH Q2A (R1) guidelines. The coefficient of determination value of the developed method was found to be 0.9988 in the concentration range of 1 μg mL−1 to 6 μg mL−1. The method was found to be linear, precise, sensitive, and robust. This method can be used for the estimation of EA in nanoformulations, bulk dosage forms, and other pharmaceutical formulations.