bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Density-Controlled Acidizing Approach: Weighted Single-Phase Retarded Acid System in Conjunction with Light-Density Gel Slugs and Fluidic Oscillator Technology Shows a Two-Fold Oil Production Increase and 10% Water Cut Reduction in a Single Run, Case Study from Iraq
Authors: Masoodi A. S. , Corrales J. S. , Nunez M. J. Ramirez , Tellez J. R. , Al-Iedani K. H. , Alarcon X. A. , El Beltagy A. H. , Taha I. M. , De Leonardis M. 
Published: November 2024

Abstract
A novel strategy to optimize hydrocarbon recovery from low-permeability carbonate reservoirs under challenging high-pressure/high- temperature (HP/HT) conditions is discussed, along with water intrusion from higher-permeability layers. The strategy uses coiled tubing (CT), a tailored 60-cp gel slug, and a single-phase hydrochloric retarded acid (SPHRA) system, densified via the density control acidizing (DCA) principle. This approach was tailored to the reservoir complexities and an HP/HT environment.
Rigorous simulation studies informed the acid solution formulation, focused on leakoff control in the upper high-permeability layer. The high gel load (60 cp) strategy combined with CT assistance facilitated precise placement and isolation of the water-bearing zone to mitigate reservoir challenges.
Enhanced CT placement using a fluid oscillating tuned frequency and amplitude (FOTFA) tool, coupled with DCA for the hydrochloric retarded acid (HRA), resulted in deep penetration into the near-wellbore (NWB) region. Post-operation analysis confirmed successful mitigation of water intrusion from higher-permeability layers, with no increase in water cut observed. Strategic HRA deployment led to substantial and sustained improvements in hydrocarbon production.
The strength of the HRA, combined with meticulous FOTFA deployment planning and a tailored DCA-enhanced acid solution, demonstrated adaptability and efficacy in extreme reservoir environments. This integrated methodology overcame challenges posed by layered reservoir structures and sets a new standard for precision in HP/HT reservoir management.
The innovative synergy of a high-viscosity gel slug and the novel HRA with FOTFA placement, customized and densified via the DCA principle, are presented. The integration of DCA into the acid system ensures adaptability and optimal performance in extreme reservoir conditions, which marks a significant advancement in reservoir stimulation practices.
AI Driven Autonomous Adaptative Feedback Welding Machine
Authors: von Querfurth Benedikt , Belhout Shems-Eddine , Knaak Christian , Mann Stefan , Abels Peter , Holly Carlo , Tatman Jonathan , Barborak Darren , Hargadine Mitch 
Published: November 2024

Abstract

The Gas Tungsten Arc Welding (GTAW) is a primary method for nuclear component fabrication and repair. Recent advancements in monitoring and automation technologies have made the shift toward fully automated arc welding more feasible, reducing the necessity for continuous human oversight. Two artificial intelligence-based networks were developed that utilize sensor-based feedback on a mechanized GTAW head. We present an image-based semantic segmentation convolutional neural network that identifies crucial features such as the weld pool, groove, wire, and electrode based on which geometric measurements are derived. A separate novel neural network predicts the weld bead geometry for multi-pass welds and inconsistent groove geometries. The application of both neural networks is a pre-requisite that enables the autonomous planning and execution of multi-pass welds to fill a groove.
Influence of TiC Particles on the Properties of AA2017 Friction Surfaced Coatings
Authors: Chludzinski Mariane , Vivas Javier , Vázquez-Martínez Juan Manuel , Sol Irene Del , Begiristain Egoitz Aldanondo 
Published: November 2024

Abstract

Friction Surfacing (FS) is a solid-state process employed for coatings that has demonstrated advancements in manufacturing aluminium matrix composites with ceramic particle reinforcements. This study explored the effect of AA2017 aluminium rods packed with TiC in the FS process and the subsequent post-processing Friction Stir Process (FSP). The analyses were carried out by light optical and scanning electron microscope, X-ray diffractometer (XRD), microhardness, and pin-on-flat wear testing. Therefore, the reinforcement significantly enhanced the FS deposition efficiency and rate (about 31%) without affecting rod consumption. It also increased the microhardness (13.6%) and the wear resistance (13% wear volume reduction) with particles spread in layers. However, the FSP thermomechanical processes modified this morphology and generated concentrated particle lines in the upper zone. It improved the wear resistance (48% wear volume reduction) compared with free-TiC coating and relieved the previous reinforcement coating hardness. In addition, the XRD analyses revealed that both processes hardly generated new phases, indicating no interaction between the matrix and the reinforcements.
A 27 cm long straight square microchannel in viscoelastic fluid for submicron- sized particle and bacteria focusing
Authors: Cho Youngseo , Lee Min-Ho , Lee SangWook , Cho Younghak 
Published: November 2024

Abstract

Particle focusing within a flow cell is an essential step in performing flow cytometry and fluorescence-activated cell sorting (FACS). Viscoelastic particle focusing, in which particles suspended in a synthetic polymer solution migrate laterally against the main flow direction, has attracted considerable attention because it enables particle focusing without any external force. In this work, we demonstrate a viscoelastic flow focusing device that enables simple and robust focusing of submicron-sized particles in the channel center by optimizing operating conditions such as channel length, flow rate and PEO (poly(ethylene oxide)) concentration. The device was fabricated using a common soft lithography technique for the polydimethylsiloxane (PDMS) channel, which has a width of 50 µm and a height of 50 µm with a channel length of 27 cm. The focusing performance was first demonstrated using submicron-sized polystyrene (PS) beads ranging from 870 nm to 50 nm and then using biological particles such as E. coli bacteria to demonstrate the biological feasibility of the device. The PS beads, which ranged in diameter from 870 nm to 100 nm, were focused to the center of the channel, achieving over 90% of the focusing efficiency for down to 510 nm beads, and 62% of focusing efficiency even in 100nm sized bead. The device also was able to align a bacterial suspension in the center of the channel at flow rates up to 30 µL/min, demonstrating its biological relevance. The developed viscoelastic flow focusing device was able to align submicron particles within a narrow flow stream in a highly robust manner, validating its use as a flow focusing platform for high throughput and accurate flow cytometry of submicron objects.
Prediction of Ki-67 expression and malignant potential in gastrointestinal stromal tumors: novel models based on CE-CT and serological indicators
Authors: Tian Jun , Chen Weizhi 
Published: November 2024

Abstract

Background and study aims To identify more reliable imaging and serological indicators for predicting Ki-67 expression and malignant potential in gastrointestinal stromal tumors, as well as to develop a preoperative prediction model with clinical utility.
Patients and methods Patients with gastrointestinal stromal tumors diagnosed at the First Affiliated Hospital of Jinzhou Medical University between May 2018 and May 2024 were retrospectively analyzed. Univariate logistic analyses, multivariate logistic analyses, stepwise regression analyses, and LASSO regression analyses were utilized to identify Ki-67 high expression and high malignant potential risk factors for GIST. Prediction models were then constructed and nomograms developed.
Results Tumor diameter and EVFDM were found to be closely associated with Ki-67 expression, while tumor volume and IBSC were closely related to malignant potential. The two-way stepwise regression model demonstrated high accuracy and good fit. The AUCs for the Ki-67 expression model in the training and validation groups were 0.865 (95%CI 0.807-0.922) and 0.784 (95%CI 0.631-0.937) respectively. The AUCs for the malignant potential model in the training and validation groups were 0.950 (95%CI 0.920-0.980) and 0.936 (95%CI 0.867-1.000) respectively.
Conclusion The maximum diameter, growth pattern, EVFDM, peritumoral vessels, PLR, OPNI are correlated with Ki-67 high expression. Volume, contour, ulcer, IBSC and OPNI are correlated with malignant potential of gastrointestinal stromal tumors; Preoperative models developed using enhanced CT imaging can respectively predict the malignant potential and Ki-67 expression of GIST. Furthermore, when combined with serological indicators, the predictive accuracy of this model can be further enhanced.
Structural and molecular basis of FAN1 defects in promoting Huntington's disease
Authors: Pluciennik Anna , Li Fenglin , Phadte Ashutosh , Bhatia Mayuri , Barndt Sarah , III Anthony Monte Carlo , Hou CF David , Yang Ruoyu , Strock Sarah 
Published: November 2024

Abstract

FAN1 is a DNA dependent nuclease whose proper function is essential for maintaining human health. For example, a genetic variant in FAN1, Arg507 to His hastens onset of Huntington’s disease, a repeat expansion disorder for which there is no cure. How the Arg507His mutation affects FAN1 structure and enzymatic function is unknown. Using cryo-EM and biochemistry, we have discovered that FAN1 arginine 507 is critical for its interaction with PCNA, and mutation of Arg507 to His attenuates assembly of the FAN1-PCNA on a disease-relevant extrahelical DNA extrusions formed within DNA repeats. This mutation concomitantly abolishes PCNA-FAN1-dependent cleavage of such extrusions, underscoring the importance of PCNA to the genome stabilizing function of FAN1. These results unravel the molecular basis for a specific mutation in FAN1 that dramatically hastens the onset of Huntington’s disease.
Intracerebroventricular B7-H3 CAR T cells for children and young adults with diffuse intrinsic pontine glioma
Authors: Vitanza Nicholas , Ronsley Rebecca , Choe Michelle , Huang Wenjun , Seidel Kristy , Rawlings-Rhea Stephanie , Beam Madison , Steinmetzer Leonel , Wilson Ashley , Brown Christopher , Beebe Adam , Lindgren Catherine , Gustafson Joshua , Wein Amy , Holtzclaw Susan , Hoeppner Corinne , Goldstein Hannah , Browd Samuel , Hauptman Jason , Lee Amy , Ojemann Jeffrey , Crotty Erin , Leary Sarah , Perez Francisco , Wright Jason , Alonso Marta , Dun Matthew , Foster Jessica , Hurst Diana , Kong Ada , Thomsen Alison , Orentas Rimas , Albert Catherine , Pinto Navin , Annesley Colleen , Gardner Rebecca , Ho On , Pattabhi Sowmy , Wendler Jason , Gust Juliane , Park Julie , Jensen Michael 
Published: November 2024

Abstract

Diffuse intrinsic pontine glioma (DIPG) is a fatal central nervous system (CNS) tumor with a median survival of 11 months. Chimeric antigen receptor (CAR) T cells are clinically effective against hematologic malignancies, but there are limited data on their utility against CNS tumors. As B7-H3 is expressed on pediatric CNS tumors, we conducted BrainChild-03 (NCT04185038), a single-center, dose-escalation phase 1 study of repetitive intracerebroventricular (ICV) B7-H3 CAR T cells for children with recurrent/refractory CNS tumors and DIPG. Here, we report on Arm C restricted to patients with DIPG. The primary objectives were to assess feasibility and tolerability. The secondary objectives were to assess CAR T cell distribution and overall survival. Twenty-three patients with DIPG enrolled and 21 were treated with ICV B7-H3 CAR T cells using intra-patient dose escalation dose regimens (DR) beginning at 1x107 CAR T cells/dose. We established the DR4, the highest planned DR that escalated to 10x107 cells/dose, as the maximally tolerated dose regimen (MTDR). Common adverse events included fever and headache. There was 1 DLT (intratumoral hemorrhage). An intent-to-treat analysis of median overall survival of enrolled patients (n = 23) from study enrollment was 11.4 months (range: 2.7–36.8) and the median time from initial diagnosis to death (or last contact for survivors) was 18.6 months (range: 6.5–40.5) with 4 patients still alive at 18.6, 37.2, 38.3, 40.5 months from diagnosis. Ultimately, the report of this completed first-in-human trial demonstrates that repetitive ICV B7-H3 CAR T cells in pediatric and young adult patients with DIPG is tolerable, even over repeated multi-year dosing, and may improve overall survival. Main Text
Assessing shared genetic and causal links between vascular calcification, Alzheimer's disease, and cognitive traits
Authors: Adewuyi Emmanuel O , Laws Simon M 
Published: November 2024

Abstract

Observational studies suggest a link between vascular calcification and dementia or cognitive decline, but the evidence is conflicting, and the underlying mechanisms are unclear. Here, we investigate the shared genetic and causal relationships between vascular calcification—coronary artery calcification (CAC) and abdominal aortic calcification (AAC)—and Alzheimer’s disease (AD), as well as cognitive traits, by analysing large-scale genome-wide association studies summary statistics. We observed a nominally significant positive genome-wide genetic correlation between CAC and AD, which became non-significant after excluding the APOE region. CAC and AAC demonstrate significant negative correlations with cognitive performance and educational attainment. Mendelian randomisation revealed no causal association between CAC or AAC and AD or cognitive traits, except for a bidirectional borderline significance of AAC with fluid intelligence scores. Pairwise-GWAS analysis identified no shared causal SNPs (posterior probability of association [PPA]3 < 0.5). However, we found pleiotropic loci (PPA4 > 0.9), particularly on chromosome 19 with ‘mBAT-combo’ analyses revealing significant genes in shared regions, including APOE, TOMM40, NECTIN2, and APOC1. Moreover, we identified suggestively significant loci (PPA4 > 0.5) on chromosomes 1, 6, 7, 9 and 19, highlighting pleiotropic genes, including NAV1, IPO9, PHACTR1, UFL1, FHL5, and FOCAD. Current findings reveal limited genome-wide genetic correlation and no significant causal associations of CAC and AAC with AD or cognitive traits. However, significant pleiotropic loci and genes underscore shared genetic susceptibility of CAC and AAC with AD and cognitive traits, identifying targets for further investigation.
Circadian rhythms in the critical human pathogen Acinetobacter baumannii
Authors: Mussi María Alejandra , Permingeat Valentín , Mora Bárbara Perez , Migliori María , Arana Natalia , Fernández Julia , Allasia María Belén , Lamberti Melisa , Venanzio Gisela Di , Feldman Mario , Golombek Diego 
Published: November 2024

Abstract

Acinetobacter baumannii is recognized as the paradigm of multidrug resistant superbug, topping the WHO priority list of critical human pathogens. Interestingly, it senses and responds to blue light, which modulates global aspects of its physiology including the pathogenicity. We hypothesized that light could serve as a signal to synchronize the bacterial physiology to the host’s behavior, or to the environment. At environmental temperatures, light regulation is mainly governed by the BLUF-type photoreceptor BlsA. In this work, we identified the existence of daily rhythms in blsA expression displaying a robust response to light, as well as endogenous circadian rhythms in A. baumannii. In fact, we show that blsA gene expression can be synchronized to 24-hour blue light-dark cycles, which immediately resynchronizes after a phase shift due to a longer night. Upon release to constant darkness, bacterial populations present free-running oscillations with a period close to 24 hours. Furthermore, our data indicate that BlsA is involved in synchronization to the zeitgeber during light-dark cycles. Importantly, β-lactamase activity varied along the day in cultures under light-dark period, establishing a new paradigm. Our work contributes to the developing field of circadian clocks in bacterial human pathogens, which could impact the microorganisms’ lifestyle and pathogenicity.
VITALS: An Implantable Sensor Network for Postoperative Cardiac Monitoring in Heart Failure Patients
Authors: Kight Ali , Haidar Moussa , Shibata Masafumi , Ono Yoshikazu , Ikeda Gentaro , Sharir Amit , Semproni Federica , Palagani Yellappa , Taheri Sawson , Han Amy , Ma Michael , McElhinney Doff , Dual Seraina , Cutkosky Mark 
Published: November 2024

Abstract

Heart Failure (HF) is a global epidemic, with high readmission rates and significant morbidity persisting due to gaps in post-acute care. Traditional follow-up assessments often miss gradual postoperative cardiac deterioration occurring outside hospital settings. Advances in remote patient monitoring (RPM) show promise, but continuous, sensitive, and practical methods are lacking. Building on previous work introducing a durable, soft strain sensor, this research presents VITALS, an implantable strain sensing network that enables continuous biventricular, multiaxial monitoring of cardiac function. The sensor’s novel design affords a longer fatigue life than previously possible for soft, large-deformation strain sensors, while effectively minimizing shear loading effects to enhance accuracy. Additionally, the system integrates a sensor on the aorta for synchronous systolic pressure monitoring. Animal studies demonstrate VITALS’ ability to track epicardial strain with high fidelity, detect preload changes rapidly, and differentiate inotropic states. Validation against echocardiographic chamber volumes and global longitudinal strain underscores the sensor’s clinical relevance, offering a practical solution for continuous, accurate cardiac monitoring to improve patient outcomes.
Hydrodynamic Performance of a Multi-Cylinder LiDAR Buoy Prototype for Wind Assessment
Authors: Liu Tongmu , Xiang Ming , Zhou Baocheng , Zhang Xinwen 
Published: November 2024

Abstract

This paper introduces an innovative multi-cylinder LiDAR buoy prototype, designed to overcome the limitations of traditional wind towers in the realm of deep-sea wind energy assessment. Through rigorous physical model experiments, we have investigated the hydrodynamics of this novel buoy under various wave conditions, including free decay in calm water, regular wave exposure, and irregular wave simulations. Our analysis reveals that the multi-cylinder buoy's natural frequency effectively evades resonance with primary wave frequencies, offering a significant advancement in technology. In regular wave tests, the buoy showed minimal motion, highlighting the impact of wave height on its dynamic behavior. In irregular wave tests, a pronounced response peak was observed near the natural frequency, yet the overall motion amplitude remained low, indicating excellent wave resistance. Comparatively, the multi-cylinder buoy demonstrated a lower motion response and superior stability than traditional single-cylinder buoys. This study not only facilitates the development and deployment of multi-cylinder buoys but also lays the groundwork for future hydrodynamic performance studies through numerical simulations, enriching the scientific understanding of buoyancy technology in wind energy applications.
Evaluation of Hop Varieties (Humulus lupulus L.) for Their Response to HLVd, HSVd, and CBCVd Viroids in tissue cultures
Authors: Volk Helena , LAP Patricija , ČERENAK Andreja , JAKŠE Jernej 
Published: November 2024

Abstract

This study evaluates the susceptibility of various hop varieties to three viroids: Hop Latent Viroid (HLVd), Hop Stunt Viroid (HSVd), and Citrus Bark Cracking Viroid (CBCVd), all of which pose significant threats to Slovenian hop production. The experiment was conducted under in vitro conditions, involving the cultivation of 13 different hop varieties in tissue cultures, alongside the in vitro synthesis of viroid transcripts and subsequent inoculation of the plants. The plants were then monitored for growth, development, and their responses to viroid infection. The findings reveal the complex interactions between hops and viroids, with successful inoculation observed in all varieties. However, infection rates varied, with HSVd showing the highest rates of infection, followed by CBCVd and HLVd. This research enhances the understanding of viroid dynamics in hop plants, which is crucial for developing effective disease management strategies. Despite the insights gained, no resistance or tolerance to the viroids was identified in any of the tested hop varieties.
Exploring the link between white matter hyperintensities volume and cerebral blood flow in normal-appearing white matter using dual post label delays of arterial spin labeling
Authors: Cao Zhenyu , Tu Gaofeng , Cao Yulin , Wei Fuquan , Wang Jian , Sun Qiwen , Xu Zhihua 
Published: November 2024

Abstract

Objective
To explore the link between white matter hyperintensities (WMH) volume and cerebral blood flow (CBF) in normal-appearing white matter (NAWM) using dual-post label delays (PLD) arterial spin labeling (ASL) techniques.
Methods
Imaging and clinical data were analyzed from 83 patients with cerebral small vessel disease (CSVD) collected between November 2022 and July 2023. WMH volume was segmented using ITK-SNAP software. The difference in CBF between the two PLDs, ΔCBF, was calculated as CBF(PLD = 2.5s) - CBF(PLD = 1.6s). CBF values for both PLD times (PLD = 1.6s, PLD = 2.5s) and ΔCBF were quantified for NAWM regions.
Results
Pearson correlation analysis revealed significant associations between WMH volume and both CBF (PLD = 2.5s) (r = 0.298, P < 0.05) and ΔCBF (r = 0.287, P < 0.05) in NAWM. When WMH volume was stratified into tertiles, significant differences in CBF (PLD = 2.5s) and ΔCBF were observed among the tertile groups (P < 0.05). Multivariate regression analysis showed that CBF (PLD = 2.5s) and ΔCBF in NAWM were independently associated with WMH volume after adjusting for age, sex, and vascular risk factors (P < 0.05). The β coefficient for CBF (PLD = 2.5s) was 0.258 (95% CI: 0.063, 0.453), and for ΔCBF, it was 0.327 (95% CI: 0.109, 0.545).
Conclusions
Elevated WMH volume is linked to increased CBF (PLD = 2.5s) and ΔCBF in NAWM, suggesting that prolonged arterial transit time may contribute to WMH development in CSVD patients.
Enhancing 5G Communication Systems with Intelligent Reflecting Surface Assisted MIMO with Secure Multiuser scenario
Authors: Prasad Anitha S , N soujanaya 
Published: November 2024

Abstract

This study examines the application of Hybrid Reconfigurable Intelligent Surfaces (HRRIS) and Reconfigurable Intelligent Surfaces (RIS) to improve security and efficiency in edge computing environments, particularly against eavesdropping threats for multiple users. By simulating an edge computing scenario with multiple users, edge servers, and an eavesdropper, assessed the effects of various HRRIS and RIS configurations on data rates, secrecy rates, and offloading latency. The findings reveal that dynamically adjusting the phase shifts of these intelligent surfaces can substantially enhance secrecy rates and reduce latency, thereby providing a robust solution to secure data transmission and improve performance in edge computing systems