bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Billion Years of History within the Grevena-Deskati Watershed
Authors: Ghikas Dina , Rassios Anne Ewing 
Published: October 2019

The river system of West Macedonia comprises the headwaters and western extent of the Aliakmon watershed. This region has a unique and highly complex geologic history (Rassios, 2008; Rassios, 2011), many aspects of which can be inferred by examining conglomerate (river-cobble) formations in the region. These formations contain all rock types found within the modern-day river basin, as well as some which are not found within today's basin. River-deposited sediments and cobbles found along today’s Aliakmon and Venetikos River systems trace the courses of ancient river flows, and thus provide information about past climatic conditions and tectonic events. The sediments making up conglomerate formations in the region are mature, containing cobbles which have been transported, consolidated, eroded and redeposited up to five times (Rassios and Grivas, 1998). This recycling of cobbles leaves only the most durable rocks while softer rocks are destroyed via abrasion. Prehistoric peoples availed themselves of this concentrated and convenient selection of high-quality stones for the purpose of fashioning tools and weapons.
Assessing the development and implementation of the Global Trigger Tool method across a large health system in Sicily
Authors: Parrinello Vincenzo , Grasso Elena , Saglimbeni Giuseppe , Patanè Gabriella , Scalia Alma , Murolo Giuseppe , Lachman Peter 
Published: October 2019

Background: The Institute for Healthcare Improvement (IHI) has proposed a new method, the Global Trigger Tool (IHI GTT), to detect and monitor adverse events (AEs) and provide information to implement improvement. In 2015, the Sicilian Health System adopted IHI GTT to assess the number, types and severity levels of AEs. The GTT was implemented in 44 of 73 Sicilian public hospitals and 18,008 clinical records (CRs) were examined. Here we present the standardized application of the GTT and the preliminary results of 14,706 reviews of CRs. Methods: IHI GTT was adapted, developed and implemented to the local context. Reviews of CRs were conducted by 199 professionals divided into 71 review teams consisting of three individuals: two of whom had clinical knowledge and expertise, and a physician to authenticate the AE. The reviewers entered data into a dedicated IT-platform. All 44 of the public hospitals were included, with approximately 300,000 yearly inpatient admissions out of a population of approximately 5 million. In total, 14,706 randomized CRs of inpatients from medicine, surgery, obstetric and ICU wards, from June 2015 to June 2018 were reviewed. Results: In 975 (6.6%) CRs at least one AE was found. Approximately 20,000 patients of the 300,000 discharged each year in Sicily have at least one AE. In 5,574 (37.9%) CRs at least one trigger was found. A total of 1,542 AEs were found. The analysis of ROC curve shows that the presence of two triggers in a CR indicates with high probability the presence of an AE. The most frequent type of AE was in-hospital related infection. Conclusions: The GTT is an efficient method to identify AEs and to track improvement of care. The analysis and monitoring of some triggers is important to prevent AEs. However, it is a labor-intensive method, particularly if the CRs are paper-based.
Epitope mapping of an uncertain endogenous antigen implies secretogranin II peptide splicing
Authors: Howlett David R. , Clarke Iain J. , Newton Russell P. , Hart John E. 
Published: October 2019

Background: The search for a tissue-mass reducing reproductive hormone involved a bioassay-guided physicochemical fractionation of sheep blood plasma. This brought forth a candidate protein whose apparent mass on gels and in mass spectrometry (MS) was 7-8 kDa, implying a polypeptide of ~70 residues. Four purification runs gave Edman N-terminal sequences relating to 1MKPLTGKVKEFNNI14. This is bioinformatically obscure and has been resistant to molecular biological investigation. The sequence was synthesized as the peptide EPL001, against which was raised a goat polyclonal antiserum, G530. Used in an antigen capture campaign, G530 pointed to the existence of a novel derivative of secretogranin II (SgII), the neuroendocrine secretory vesicle helper protein and prohormone. The proposed SgII derivative was dubbed SgII-70, yet the sequence commonality between SgII and EPL001 is essentially NNI. Methods: Immunohistochemical (IHC) labelling with G530 is reported within rat, mouse and human cerebrovasculature and in glandular elements of the mouse intestine. Epitope mapping involved IHC peptide preabsorption, allied to deductive bioinformatics and molecular modelling in silico. Results: G530 is deemed monoepitopic in regard to both its synthetic antigen (EPL001) and its putative endogenous antigen (SgII related). The epitope within EPL001 of the anti-EPL001 antibody is inferred to be the contiguous C-terminal 9KEFNNI14. This is so because the G530 blockade data are consistent with the epitope in the mammalian endogenous antigen being part contiguous, part non-contiguous KE·F·NNI, ex hypothesi. The observed immunostaining is deduced to be due to pre-SgII-70, which has a non-C-terminal NNI, and SgII-70, which has an N-terminal MLKTGEKPV/N and a C-terminal NNI (these two motifs being in the reverse order in the SgII parent protein). Conclusion: The present data are consistent with the hypothesis that the anti-EPL001 antibody binds to an SgII-related epitope. SgII is apparently subject to peptide splicing, as has been reported for the related chromogranin A.
DA FUNÇÃO SOCIAL À FUNÇÃO ECONÔMICA DA TERRA: impactos da Lei nº 13.465/17 sobre as políticas de regularização fundiária e o direito à cidade no brasil.
Authors: Alfonsin Betânia De Moraes , Pereira Pedro Prazeres Fraga , Lopes Débora Carina , Rocha Marco Antônio , Boll Helena Corrêa 
Published: October 2019

O artigo analisa o novo modelo de Regularização Fundiária Urbana adotado pela Lei 13.465/17, demonstrando a ruptura paradigmática ocorrida em relação ao paradigma anterior consagrado pelo Estatuto da Cidade. A passagem de um modelo que priorizava o direito à cidade e a função social da propriedade para outro que privilegia a mera titulação e a função econômica da terra é desvelada a partir da análise comparativa de vários dispositivos legais. A pesquisa, realizada utilizando o método dialético, conclui que o Brasil, com tal alteração no marco legal da terra, insere-se em um movimento internacional de financeirização da moradia, impondo uma derrota ao direito à cidade no primeiro país do mundo que o positivou em sua ordem jurídico-urbanística.
Palliative radiotherapy: what do nurses know?
Authors: Hayden Kim , Connolly Michael 
Published: October 2019

Background: palliative radiotherapy can improve quality of life for patients who are symptomatic of advanced cancers. However, this treatment modality is underused and is often mistimed, which negates its potential benefit. Aim: the aim of this study was to assess nursing knowledge of palliative radiotherapy in the context of caring for patients with a cancer diagnosis. Methods: a quantitative method of research was employed using a questionnaire to assess palliative radiotherapy knowledge among a purposive sample of 162 oncology and palliative care nurses. Findings: the response rate was 48.14%. More than half of respondents reported their knowledge of radiotherapy as insufficient for their practice and almost all agreed they would benefit from more education. Conclusion: nurses require more training to identify when palliative radiotherapy would be an effective symptom control option; specific areas of focus for developing future radiotherapy educational programmes are highlighted.
Nuova edizione commentata di P.Stras. P. gr. 2340 La più antica antologia epigrammatica su papiro?
Authors: Floridi Lucia , Maltomini Francesca 
Published: October 2019

Abstract
New annotated critical edition of P.Strasb. P. gr. 2340 (beginning of the III century BC), probably containing the fragments of an anthology of Greek epigrams.
Mycenaean wo-ra-we-sa
Authors: Marcos Macedo José 
Published: October 2019

Abstract
The Mycenaean adjective wo-ra-we-sa refers to a chariot, but its meaning is not readily inferable form the context and its etymology is still disputed. The present paper examines the different hypotheses brought forward to explain wo-ra, of which wo-ra-we-sa is a derivative in *-u̯ent-, and it offers a new solution for its etymology. It argues that wo-ra is a feminine ā -stem action noun meaning “the twisted, braided, or plaited thing” which goes back either to *u̯ol(h1)-eh2- or to *u̯ṓ l(h1)-eh2-, from the root *u̯el(h1)- ‘to turn, wallow, roll’. Formally and semantically wo-ra may be shown to share the same root as alphabetic Greek εὐλή ‘maggot, caterpillar’ and Homeric εὔληρα ‘reins’ (Il. 23.481), being either a feminine action noun in the o-grade (/wolā /) built directly to the verbal root *u̯el(h1)- or a lengthened ō -grade (/wō lā /). Crucially, the ideogram *253 which follows [wo-]ra and wo-ra-e looks like a bosal, a type of noseband which is part of a bridle without bit. That being so, wo-ra-we-sa /wō̆lā wessa/ would mean ‘provided or fitted with a (braided or laced) bridle’.
Crystal structure of (dimethyl sulfoxide)-dioxido-[2-hydroxy-N′-(4-oxo-4-phenylbutan-2-ylidene)benzohydrazidato κ3
N,O,O′]molybdenum(VI), C19H20MoN2O6S
Authors: Lo Kong Mun , Lee See Mun , Tiekink Edward R.T. 
Published: October 2019

Abstract
C19H20MoN2O6S, orthorhombic, Pbca (no. 61), a = 13.4060(1) Å, b = 16.5112(1) Å, c = 17.6357(1) Å, V = 3903.65(4) Å3, Z = 8, R
gt(F) = 0.0217, wR
ref(F
2) = 0.0602, T = 100(2) K.
Gimp Sue Gets the Girl: Disability in Twilight Fanfiction
Authors: Dreisinger Olivia 
Published: October 2019

While many fan studies scholars have written about the Mary Sue through gender and sexuality, disability is often entirely overlooked. I take up this gap in scholarship in the following paper, looking at the various intersections between disability and Twilight fanfiction. I look closely at two Disabled!Twilight fanfics written by disabled authors—LisbethsGirlfriend’s Forgive Me for Loving You, and The Plasma’s Coping with Change. Through their respective fics, these disabled Mary Sues, or Gimp Sues, address issues of sex, disability, and coming out, questioning just who has the right to tell stories, and what stories get told.
RANK DARI GRUP DIHEDRAL TIGA (D3) YANG BERAKSI ATAS X^((1))
Authors: Nurlaela Teuis Siti , Sukaesih Esih 
Published: October 2019

Misalkan adalah suatu grup dan adalah bukan himpunan kosong, maka aksi dari atas adalah suatu pemetaan, dengan dan terdapat yang bersifat identitas dan asosiatif. Suatu rank dari grup aksi yaitu banyaknya orbit dari grup tersebut. Pada jurnal ini akan ditunjukkan bahwa rank dari grup dihedral 3 ( ) yang beraksi atas adalah .
Bifurkasi pada Sistem Lorenz Modifikasi
Authors: Ilahi Fadilah , Lestari Asri Puji 
Published: October 2019

Penelitian ini membahas sistem Lorenz modifikasi yang menggambarkan pergerakan angin di atmosfer yang mengalami turbulensi karena adanya perubahan temperatur yang dipengaruhi oleh intensitas gerak fluida, temperatur horizontal serta temperatur vertikal. Sistem ini memiliki tiga parameter real, yaitu parameter yang menentukan distribusi temperatur, nilai yang bergantung dengan keadaan geometri suatu fluida serta nilai perbedaan temperatur antara bagian atas dan bagian bawah lapisan. Analisis dinamik pada sistem ini menentukan titik ekuilibrium, nilai eigen serta menentukan kestabilan dari setiap titik ekuilibrium. Sistem ini memiliki dua titik ekuilibrium. Berdasarkan analisis yang telah dilakukan diperoleh bahwa titik ekuilibrium yang pertama dinyatakan tidak stabil dan titik ekulibrium yang kedua stabil bersyarat. Untuk mengetahui bifurkasi dari sistem ini, diambil 27 kondisi dengan parameter yang berbeda-beda. Dengan mengambil 27 kondisi ini dapat dilihat perubahan kestabilannya. Karena adanya perubahan kestabilan, maka sistem ini termasuk bifurkasi transcritical. Limit cycle yang terbentuk adalah limit cycle stabil karena bagian luar dan dalam limit cycle mendekati limit cycle.
Anti-donor MHC Class II Alloantibody Induces Glomerular Injury in Mouse Renal Allografts Subjected to Prolonged Cold Ischemia
Authors: Gorbacheva Victoria , Fan Ran , Beavers Ashley , Fairchild Robert L. , Baldwin William M. , Valujskikh Anna 
Published: October 2019

Significance Statement
Prolonged cold-ischemia storage of donor organs is a major risk factor for acute and chronic graft injury, but the immunologic mechanisms underlying deleterious effects of cold-ischemia time and subsequent ischemia-reperfusion injury are poorly defined. In a mouse model of allogeneic kidney transplantation, the authors found that subjecting donor kidneys to prolonged cold ischemia enhanced early humoral and cellular anti-donor immune responses. In particular, recipients generated donor-specific antibodies against MHC class II (but not class I) antigens and exhibited extensive transplant glomerulopathy. The results indicate that antibodies against donor MHC class II antigens are critical mediators of glomerular injury caused by prolonged cold ischemia. Establishing mechanistic links between cold-ischemia storage and late transplant tissue injury may guide future therapies to ameliorate manifestations of chronic kidney allograft rejection.

Background
The mechanisms underlying the effects of prolonged cold-ischemia storage on kidney allografts are poorly understood.

Methods
To investigate effects of cold ischemia on donor-reactive immune responses and graft pathology, we used a mouse kidney transplantation model that subjected MHC-mismatched BALB/c kidney allografts to cold-ischemia storage for 0.5 or 6 hours before transplant into C57BL/6 mice.

Results
At day 14 post-transplant, recipients of allografts subjected to 6 versus 0.5 hours of cold-ischemia storage had increased levels of anti–MHC class II (but not class I) donor-specific antibodies, increased donor-reactive T cells, and a significantly higher proportion of transplant glomeruli infiltrated with macrophages. By day 60 post-transplant, allografts with a 6 hour cold-ischemia time developed extensive glomerular injury compared with moderate pathology in allografts with 0.5 hour of cold-ischemia time. Pathology was associated with increased serum levels of anti–class 2 but not anti–class 1 donor-specific antibodies. Recipient B cell depletion abrogated early macrophage recruitment, suggesting augmented donor-specific antibodies, rather than T cells, increase glomerular pathology after prolonged cold ischemia. Lymphocyte sequestration with sphingosine-1-phosphate receptor 1 antagonist FTY720 specifically inhibited anti–MHC class II antibody production and abrogated macrophage infiltration into glomeruli. Adoptive transfer of sera containing anti-donor MHC class II antibodies or mAbs against donor MHC class II restored early glomerular macrophage infiltration in FTY720-treated recipients.

Conclusions
Post-transplant inflammation augments generation of donor-specific antibodies against MHC class II antigens. Resulting MHC class II–reactive donor-specific antibodies are essential mediators of kidney allograft glomerular injury caused by prolonged cold ischemia.
Onland and Offshore Extrinsic Fabry–Pérot Optical Seismometer at the End of a Long Fiber
Authors: Bernard Pascal , Feron Romain , Plantier Guy , Nercessian Alexandre , Couteau Julien , Sourice Anthony , Feuilloy Mathieu , Cattoen Michel , Seat Han‐Cheng , Chawah Patrick , Chéry Jean , Brunet Christophe , Boudin Frédérick , Boyer Daniel , Gaffet Stéphane , Geli Louis , Pelleau Pascal 
Published: October 2019

ABSTRACTWe report here the design, performance, and in situ demonstration, on‐land and offshore, of an innovative high‐resolution low‐cost optical (laser) seismometer. The instrument was developed within the Laser Interferometry for Earth Strain project (French Agence Nationale de la Recherche [ANR] program), and first tested at the low‐noise underground laboratory Laboratoire Souterrain à Bas Bruit (LSBB, France). It is based on Fabry–Pérot optical interferometry between the extremity of a probing optical fiber and a reflecting mirror secured to the mobile mass of a passive 2 Hz geophone. The detection technique is based on the wavelength modulation of the laser diode (1310 nm), which allows the separation of the optical power into two signals in quadrature, thanks to an heterodyne technique. The relative displacement of the mobile mass is retrieved in real time by the phase unwrapping of these two signals. At LSBB, the fiber was 3 km long. It recorded many teleseismic earthquakes and a few regional ones, and resolves the low‐seismic noise of the Earth for periods up to 6 s, presenting an acceleration noise floor lower than 1  ng/Hz in the 0.3–5 Hz range. A three‐component version of this fiber‐based interferometric 2 Hz geophone has been recently constructed, shielded in a hyperbaric container, and installed offshore for test in Brittany (France) in April 2018, with an improved control system. Its record of the marine ambient noise matches those of a collocated commercial broadband seismometer for periods up to 50 s. This opens promising perspectives for large‐scale ocean bottom instrumentation with up to 50‐kilometer‐long optical lines; an installation is planned for 2020, off Guadeloupe, with a 5‐kilometer‐long fiber cable. It may also prove useful for installations in other challenging and exposed environments, such as deep hot boreholes, active volcanoes, unstable landslides, for real‐time monitoring in regions with high natural hazard, but also for seismic monitoring of geoindustries.
Seismic Intensity Attenuation for Intraplate Earthquakes in Brazil with the Re‐Evaluation of Historical Seismicity
Authors: Quadros Lúcio , Assumpção Marcelo , Trindade de Souza Ana Paula 
Published: October 2019

ABSTRACTIntensity evaluation attempts to quantify a qualitative description of the effects observed in an earthquake ranked in terms of how strong it was felt and the amount of damage. Despite its qualitative nature, intensity data are essential to study both historical and recent earthquakes such as in earthquake hazard studies and in which dense accelerometric data are missing. The magnitude of historical earthquakes in Brazil has been determined with relations involving magnitude and felt area. Intensity attenuation equations (decay of intensity as a function of magnitude, depth, and distance) determined in other regions of the world are intrinsically dependent on the crustal tectonic characteristics and cannot be applied to Brazil without proper evaluation. We determined an intensity attenuation equation using 20 earthquakes in Brazil and neighboring intraplate areas, in the magnitude range mb 3.5–6.2 and hypocentral distances up to 720 km.The best attenuation model was I=0.995M−1.505logR−0.00116R+2.08 (standard deviation = 0.778), in which M is the magnitude (mb) and R is the hypocentral distance (in kilometers). The uncertainties of the estimated magnitudes using this equation are around mb±0.72 for events with 30 or more intensity points.We tested the new equation with intensity data from two important events: the 1939 offshore earthquake (mb 6) in southern Brazil and the 2018 Venezuela earthquake (mb 6.9). The fit was reasonable for both earthquakes, with a root mean square residual of 1.0 and 1.1 intensity units, respectively.We also re‐evaluated the 1861 earthquake in southeast Brazil. The new epicenter was 23.1° S 44.7° W with a magnitude of mb 5. The epicenter was located onshore, but the estimated uncertainties include a large offshore region. Given that, the location of the 1861 event remains uncertain.
Is sedentary behavior associated with dysglycemia in youth with obesity?
Authors: Alvarez de Sotomayor, BS Alan , El-Mikati, MD Hala , Yazel-Smith, MS, MCHES Lisa , Hannon, MD, MS Tamara 
Published: October 2019

Background and Hypothesis: The childhood obesity epidemic is linked with an increase in dysglycemia and type 2 diabetes (T2D) amongst youth.i Adolescence is associated with decreased levels of physical activityii, however, there is a paucity of research investigating physical activity measures and dysglycemia in youth. We hypothesize that decreased physical activity and/or increased sitting time is positively correlated with dysglycemia.
Project Methods: Study participants were youth aged 10-21y with a BMI >85th percentile for age and gender. Accelerometers (activPAL) and the FELS Physical Activity Questionnaire (FELS PAQ) were used to assess objective and selfreported physical activity levels. Glucose tolerance was assessed with 2-hour oral glucose tolerance tests (OGTT). Independent t-tests were used to compare physical activity levels for participants with normal glucose tolerance (NGT) and dysglycemia. Correlation analysis was performed to evaluate relationships between measures of physical activity and OGTT measures.
Results: Participants with NGT (N=27) and dysglycemia (N=26) had comparable demographics; age, race, and ethnicity. Hemoglobin A1c (HbA1c) (p =0.002), average fasting glucose (p<0.00), indices of insulin resistance (HOMA-IR) (p=.023), insulin secretion (disposition index, DI, a marker of risk for T2D) (p=.008), 2-hour-OGTT measures for glucose (p=.004) and insulin (p=.002) differed between groups. There were not group differences for objective or selfreported measures of physical activity. For the entire cohort, sitting time was positively associated with OGTT 2hr glucose (r=.38, p=.03). However, a subgroup analysis showed that the association between sitting time and OGTT 2hr glucose was significant in the dysglycemia group only (r =.64, p=.006, vs r =.016, p=.95 for NGT group). Self-reported measures of activity (Likert scores) and OGTT measures for insulin and glucose were positively correlated.
Conclusion and Potential Impact: Increased sitting time is associated with impaired glucose tolerance in youth with obesity at risk for T2D.
iVan der Aa MP, Fazeli Farsani S, Knibbe CA, de Boer A, van der Vorst MM. Population-Based Studies on the Epidemiology of Insulin Resistance in Children. J Diabetes Res. 2015;2015:362375.
iiDumith SC, Gigante DP, Domingues MR, Kohl HW. Physical activity change during adolescence: a systematic review and a pooled analysis. International Journal of Epidemiology. 2011;40(3):685-98.