bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benchmarking Parametric and Machine Learning Models for Genomic Prediction of Complex Traits
Authors: Azodi Christina B , Bolger Emily , McCarren Andrew , Roantree Mark , de los Campos Gustavo , Shiu Shin-Han 
Published: September 2019

AbstractThe usefulness of genomic prediction in crop and livestock breeding programs has prompted efforts to develop new and improved genomic prediction algorithms, such as artificial neural networks and gradient tree boosting. However, the performance of these algorithms has not been compared in a systematic manner using a wide range of datasets and models. Using data of 18 traits across six plant species with different marker densities and training population sizes, we compared the performance of six linear and six non-linear algorithms. First, we found that hyperparameter selection was necessary for all non-linear algorithms and that feature selection prior to model training was critical for artificial neural networks when the markers greatly outnumbered the number of training lines. Across all species and trait combinations, no one algorithm performed best, however predictions based on a combination of results from multiple algorithms (i.e., ensemble predictions) performed consistently well. While linear and non-linear algorithms performed best for a similar number of traits, the performance of non-linear algorithms vary more between traits. Although artificial neural networks did not perform best for any trait, we identified strategies (i.e., feature selection, seeded starting weights) that boosted their performance to near the level of other algorithms. Our results highlight the importance of algorithm selection for the prediction of trait values.
Actin and Nuclear Envelope Components Influence Ectopic Recombination in the Absence of Swr1
Authors: Morillo-Huesca Macarena , Murillo-Pineda Marina , Barrientos-Moreno Marta , Gómez-Marín Elena , Clemente-Ruiz Marta , Prado Félix 
Published: September 2019

Abstract
The accuracy of most DNA processes depends on chromatin integrity and dynamics. Our analyses in the yeast Saccharomyces cerevisiae show that an absence of Swr1 (the catalytic and scaffold subunit of the chromatin-remodeling complex SWR) leads to the formation of long-duration Rad52, but not RPA, foci and to an increase in intramolecular recombination. These phenotypes are further increased by MMS, zeocin, and ionizing radiation, but not by double-strand breaks, HU, or transcription/replication collisions, suggesting that they are associated with specific DNA lesions. Importantly, these phenotypes can be specifically suppressed by mutations in: (1) chromatin-anchorage internal nuclear membrane components (mps3∆75-150 and src1∆); (2) actin and actin regulators (act1-157, act1-159, crn1∆, and cdc42-6); or (3) the SWR subunit Swc5 and the SWR substrate Htz1. However, they are not suppressed by global disruption of actin filaments or by the absence of Csm4 (a component of the external nuclear membrane that forms a bridging complex with Mps3, thus connecting the actin cytoskeleton with chromatin). Moreover, swr1∆-induced Rad52 foci and intramolecular recombination are not associated with tethering recombinogenic DNA lesions to the nuclear periphery. In conclusion, the absence of Swr1 impairs efficient recombinational repair of specific DNA lesions by mechanisms that are influenced by SWR subunits, including actin, and nuclear envelope components. We suggest that these recombinational phenotypes might be associated with a pathological effect on homologous recombination of actin-containing complexes.
Race as a component of set and setting: How experiences of race can influence psychedelic experiences
Authors: Neitzke-Spruill Logan 
Published: September 2019

Background and aims
Set and setting function both as a concept that guides research and practice with psychedelic drugs and as a meme aimed at reducing harm among psychedelic users. Referring to non-pharmacological factors that shape drug experiences, the concept of set and setting was popularized in the West during the mid-20th century. However, little theoretical development has occurred regarding what falls under the umbrella of set and setting since its conception.

Methods
By bridging set and setting theory with research from the fields of social psychology and sociology of medicine, this review calls attention to how race can contribute the set and setting for a psychedelic experience.

Results
I argue that psychosocial factors influencing racial differences in mental health also constitute meaningful differences in set. Furthermore, I suggest that the character of race relations in the United States provides a distinct cultural setting for racialized psychedelic users, both in therapeutic and naturalistic contexts. In turn, racial identification may contribute to the variation in framing and interpretation of psychedelic experiences.

Conclusion
These considerations have important implications beyond understanding non-pharmacological influences on psychedelic experiences, including developing protocols for clinical applications of psychedelics, educating future practitioners, and meeting the needs of diverse patient populations.
Responsabilidades éticas en la práctica de enfermería en instituciones de alta complejidad
Authors: Parra Dora Inés , Peñaloza Jaimes Senieth Deyanire , Cárdenas Villabona María Vivina , Rey de Cruz Nelly , Amaya Díaz Helda Cecila , Arboleda de Pérez Ligia Betty , Corredor Jurado Yaneth 
Published: September 2019

Introducción: Los códigos deontológicos, permiten guiar las acciones para un apropiado ejercicio profesional. En Colombia, la Ley 911 del 2004, establece las disposiciones legales sobre ética para el ejercicio de la enfermería y conceptualiza el acto de cuidado. Objetivo: Determinar la percepción de las enfermeras sobre las responsabilidades éticas en la práctica profesional y la relación con el servicio e institución donde laboran. Materiales y Métodos: Estudio de corte transversal en enfermeras que laboran en instituciones públicas y privadas. Se realizó análisis descriptivo y estratificado. Resultados: Las enfermeras perciben en alto porcentaje que siempre cumple lo establecido en el Título III. Hubo relación estadísticamente significativa entre percepción y la institución donde labora para los ítems de conducta respetuosa, objeción de conciencia y registros de enfermería claros y entre percepción versus servicios, para los ítems de conducta respetuosa, ubicación de acuerdo a la experiencia y formación y diligenciamiento de registros claros, secuenciales y sin errores. Discusión: Los resultados de este estudio permiten evidenciar elementos fundamentales del actuar ético de enfermería referidos en la literatura científica. Conclusiones: La práctica de enfermería implica una serie de responsabilidades éticas con los sujetos de cuidado que pueden variar según el contexto donde esta se desarrolle. En este estudio, se concluyó que los registros de enfermería, la objeción de conciencia, la ubicación de acuerdo a la experiencia y formación académica eran fundamentales para el ejercicio de la práctica y estaban relacionados con la institución y servicio donde se laboraba.
Como citar este artículo: Parra DI, Peñaloza SD, Cárdenas MV, Rey N, Amaya HC, Arboleda LB, et al. Responsabilidades éticas en la práctica de enfermería en instituciones de alta complejidad. Rev Cuid. 2019; 10(3): e662. http://dx.doi.org/10.15649/cuidarte.v10i3.662
Proximal Tubule Translational Profiling during Kidney Fibrosis Reveals Proinflammatory and Long Noncoding RNA Expression Patterns with Sexual Dimorphism
Authors: Wu Haojia , Lai Chun-Fu , Chang-Panesso Monica , Humphreys Benjamin D. 
Published: September 2019

Significance Statement
Having a comprehensive transcriptional profile of the proximal tubule in health and fibrosis would likely enhance understanding of fibrosis and perhaps help explain why CKD progresses more quickly in males versus females. To obtain a more complete picture of gene expression in the proximal tubule, the authors performed deep translational profiling of this segment in a mouse model of kidney fibrosis. Their findings demonstrate substantial sex differences in transcripts expressed in proximal tubule cells of males versus females, and indicate that the proximal tubule drives fibrosis through inflammatory and profibrotic paracrine signaling. The study also identified 439 long noncoding RNAs expressed in the proximal tubule, 143 of which undergo differential regulation in fibrosis, suggesting that this type of RNA has unanticipated regulatory roles kidney fibrosis.

Background
Proximal tubule injury can initiate CKD, with progression rates that are approximately 50% faster in males versus females. The precise transcriptional changes in this nephron segment during fibrosis and potential differences between sexes remain undefined.

Methods
We generated mice with proximal tubule–specific expression of an L10a ribosomal subunit protein fused with enhanced green fluorescent protein. We performed unilateral ureteral obstruction surgery on four male and three female mice to induce inflammation and fibrosis, collected proximal tubule–specific and bulk cortex mRNA at day 5 or 10, and sequenced samples to a depth of 30 million reads. We applied computational methods to identify sex-biased and shared molecular responses to fibrotic injury, including up- and downregulated long noncoding RNAs (lncRNAs) and transcriptional regulators, and used in situ hybridization to validate critical genes and pathways.

Results
We identified >17,000 genes in each proximal tubule group, including 145 G-protein–coupled receptors. More than 700 transcripts were differentially expressed in the proximal tubule of males versus females. The >4000 genes displaying altered expression during fibrosis were enriched for proinflammatory and profibrotic pathways. Our identification of nearly 150 differentially expressed proximal tubule lncRNAs during fibrosis suggests they may have unanticipated regulatory roles. Network analysis prioritized proinflammatory and profibrotic transcription factors such as Irf1, Nfkb1, and Stat3 as drivers of fibrosis progression.

Conclusions
This comprehensive transcriptomic map of the proximal tubule revealed sexually dimorphic gene expression that may reflect sex-related disparities in CKD, proinflammatory gene modules, and previously unappreciated proximal tubule–specific bidirectional lncRNA regulation.
Leitura literária na escola: uma verificação da interpretação do gênero conto
Authors: Sampaio Emilio Davi , Duarte Erica Valmaceda de Lima Icassatti 
Published: September 2019

<p>Objetivando constatar o nível de leitura de alunos recém ingressos no ensino médio, este trabalho foi desenvolvido por meio da aplicação de dois questionários. O primeiro procurou verificar o nível de leitura e a interpretação literária desses alunos. Buscamos averiguar se eles vão ingressar na nova etapa de ensino preparados como leitores críticos. Para essa constatação, utilizamos como instrumentos a leitura interpretativa do conto <em>Uma Vela Para Dario</em>, de Dalton Trevisan. O segundo questionário serviu para a coleta de dados socioculturais, estes importantes para conhecermos a realidade dos sujeitos de nossa investigação. Para embasar nossas análises utilizamos teóricos que discutem a temática, entre eles Colomer, Silva, Maia e Gotlib. Estes autores nos auxiliaram a interpretar os dados que nos levaram a conhecer com mais propriedade nosso objeto de pesquisa. Isso possibilitou verificarmos o uso da literatura no processo de ensino, sabendo que esta tem grande funcionalidade na construção do leitor. </p>
CAN COLLABORATIVE LEADERSHIP BE A SOUL FOR DEVELOPMENT OF SUSTAINABLE TOURISM? : STUDY IN KARANGANYAR DISTRICT
Authors: Nugraheni Jacika Pifi , Sudarmo Sudarmo , Wahyunengseh Rutiana Dwi 
Published: September 2019

Tourism development is believed to be able to improve the economy of local communities, even tourism development is one strategy in reducing poverty, especially in rural communities. But in Indonesia rapid tourism development has the potential to isolate the economy of local communities. This occurs because the tourism business is managed on a large scale by the private sector. Various studies support that this weakness occurs because there is no maximum empowerment of local communities in managing it, so that the community loses control of tourism development. This study aims to interrogate how collaborative leadership is carried out to support sustainable tourism development and how collaborative leadership should be carried out as an effort to effectively increase tourism's contribution to the local economy. To analyze this, this study uses four collaborative leadership variables namely embracing, empowering, involving and mobilizing. The method used is literature study and interview. Research locus in Karanganyar Regency. The results of the analysis show that there is no maximum empowerment of local communities in developing sustainable tourism because of there are obstacles in implementing collaboration are from the agenda of screening and integration of political aspects. This research also suggests that in order to achieve sustainable tourism development it is necessary to develop institutions in the embracing process in the collaborative leadership agenda as well as cooperation between regions. Thus, this paper can contribute theoretically in linking between collaborative leadership models and institutional development for effective sustainable tourism development.
Key Word : collaborative;community empowerment; institutional; leadership; tourism
COORDINATION POVERTY ALLEVIATION PROGRAM, AN ANALYSIS BASED ON INSTRUMENTAL AND INSTITUTIONAL PERSPECTIVE
Authors: Akbar Gugun Geusan , Kania Ikeu , Ulumudin Aceng , Ramdhani Abdullah 
Published: September 2019

Nowadays, the government has launched various programs for the poor people as a part of the poverty alleviation program. The launch of the various programs involved many parties so that coordination became one of the problems in the poverty prevention program policy in Indonesia. This research was aimed to analyse the coordination of poverty prevention program in Garut as one of the poorest districts in West Java Province. The research used qualitative methods. Data were collected through primary data and secondary data collection. Primary data was collected by interviews and focus group discussions. Secondary data was collected by a review of the literature and data sharing from magazines, reports, news media and others. As the analytical tool, it used the coordination perspectives of Cristensen and Laegreid which adduce the theoretical perspectives related with coordination between organizations, namely instrumental and institutional.The results of the study showed that coordination between organizations in the poverty prevention program is still not good and still has several factors that become obstacles. Suggestions that can be proposed are the need of leadership development that is collegial collectives. Another suggested thing is the need of common arena development that is aimed to be communication instrument, vision equalization, mission and objectives. It is also aimed to make more integrated program planning from each organization so that the coordination inhibiting factors can be eliminated.
Keywords: Poverty Prevention, Coordination Between Organization, Instrumental Perspective, Institutional Perspective
Conexão de Manchas Verdes Urbanas em São Paulo [SP]. Estudo de caso
Authors: Suassuna Sarah Bezerra , Franco Maria de Assunção Ribeiro 
Published: September 2019

Este artigo discorre sobre a caracterização eco social de manchas verdes urbanas e como ela pode influenciar em decisões voltadas para o Planejamento Urbano Ambiental e na implantação de elementos de infraestrutura verde. Como estudo de caso, foram selecionadas duas manchas verdes localizadas na região Centro - Oeste do município de São Paulo: o Parque Alfredo Volpi e o Parque do Povo. A metodologia utilizada para tal caracterização baseou-se, principalmente, no conceito de Mosaico Territorial e o modelo mancha - corredor - matriz de Richard Forman (1995), no conceito de Infraestrutura Verde e o sistema de hubs, links, e sites elaborados por Benedict e McMahon (2006) e nas informações concedidas pelo setor administrativo de ambos os parques.
The Contested Whiteness of Arab Identity in the United States: Implications for Health Disparities Research
Authors: Abboud Sarah , Chebli Perla , Rabelais Em 
Published: September 2019

In response to the Institute on Minority Health and Health Disparities’ (NIMHD) new health disparities research framework, we call on the National Institutes of Health (NIH) to acknowledge Arabs in the United States as a health disparity population. Arab classification as White leads to their cultural invisibility and perpetuates a cycle of undocumented health disparities.We provide examples of how this contested identity reinforces challenges associated with identifying this population and contributes to enactments of structural violence and undocumented health disparities. Decades of research with Arabs in the United States provides consistent evidence that their health does not fit the health profile of White Americans and that Arabs do not benefit from Whiteness and White privilege associated with their White racial categorization. On the contrary, Arabs in the United States experience discrimination and health disparities that require urgent attention; this can be achieved only by identifying the population with a racial category other than White.We conclude with recommendations to NIH and NIMHD to revise their definition of health disparity populations to include Arabs in the United States.
Preterm Birth in China Between 2015 and 2016
Authors: Chen Chang , Zhang Jin Wen , Xia Hong Wei , Zhang Hui Xin , Betran Ana Pilar , Zhang Lin , Hua Xiao Lin , Feng Li Ping , Chen Dan , Sun Kang , Guo Chun Ming , Qi Hong Bo , Duan Tao , Zhang Jun 
Published: September 2019

Objectives. To describe the incidence, risk factors, and potential causes of preterm birth (PTB) in China between 2015 and 2016.Methods. The China Labor and Delivery Survey was a population-based multicenter study conducted from 2015 to 2016. We assigned each birth a weight based on the sampling frame. We calculated the incidence of PTB and the multivariable logistic regression, and we used 2-step cluster analysis to examine the relationships between PTB and maternal, fetal, and placental conditions.Results. The weighted nationwide incidence of PTB was 7.3% of all births and 6.7% of live births at 24 or more weeks of gestation. Of the PTBs, 70.5% were born after 34 weeks and 42.7% were iatrogenic. Nearly two thirds of all preterm births were attributable to maternal, fetal, or placental conditions, and one third had unknown etiology.Conclusions. This study provided information on the incidence of PTB in China and identified several factors associated with PTB. The high frequency of iatrogenic PTB calls for a careful assessment and prudent management of such pregnancies, as PTB has short- and long-term health consequences.
Firearm and Nonfirearm Violence After Operation Peacemaker Fellowship in Richmond, California, 1996–2016
Authors: Matthay Ellicott C. , Farkas Kriszta , Rudolph Kara E. , Zimmerman Scott , Barragan Melissa , Goin Dana E. , Ahern Jennifer 
Published: September 2019

Objectives. To evaluate whether the Operation Peacemaker Fellowship, an innovative firearm violence-prevention program implemented in Richmond, California, was associated with reductions in firearm and nonfirearm violence. Methods. We compiled city- and jurisdiction-level quarterly counts of violent firearm and nonfirearm incidents from statewide records of deaths from and hospital visits for homicide and assault (2005–2016) and from nationwide crime records of homicides and aggravated assaults (1996–2015). We applied a generalization of the synthetic control method to compare observed patterns in firearm and nonfirearm violence after implementation of the program (June 2010) to those predicted in the absence of the program, using a weighted combination of comparison cities or jurisdictions. Results. The program was associated with reductions in firearm violence (annually, 55% fewer deaths and hospital visits, 43% fewer crimes) but also unexpected increases in nonfirearm violence (annually, 16% more deaths and hospital visits, 3% more crimes). These associations were unlikely to be attributable to chance for all outcomes except nonfirearm homicides and assaults in crime data. Conclusions. The Operation Peacemaker Fellowship may have been effective in reducing firearm violence in Richmond but may have increased nonfirearm violence.
Diagnostic value of HSP90α and Related Markers in Lung Cancer
Authors: Yuan Zhimin , Hong Songlin , Li Lin , He Lin , Xiao Peng , Tang Ting , Shi Changbei , Mu Yudong , Sun Chen , Shang Yuchen , Wang Qing , Yuan Bin 
Published: September 2019

Abstract
Aim: To prove the expression of heat shock protein 90α (HSP90α) in lung cancer and the clinical value of HSP90α and related markers in the diagnosis of lung cancer.
Methods: The concentrations of HSP90α and related markers were detected in the blood of 560 lung cancer patients by enzyme-linked immunosorbent assay for analyzing the statistical differences of HSP90α in patients' age, gender, pathological types, tumour staging and metastasis status, as well as the differences and evaluate the value of HSP90α and related markers in lung cancer diagnosis.
Results: The results showed no statistical difference in HSP90α among age and gender groups (P>0.05); In the group by lung cancer type, statistical differences were found in the HSP90α level between the small cell lung cancer (SCLC) group and the squamous carcinoma (SLC) group (P<0.05); In the group by staging, the HSP90α level of high staging was significantly higher than that low staging, and the HSP90α level at Ⅰ/Ⅱ/Ⅲ/Ⅳ shows statistical differences among the groups (P<0.05); The test result of HSP90α was higher in the metastatic group than in the non-metastatic group significantly, and the significant difference between the two groups (P<0.05). The r value of the HSP90α and related markers in the diagnosis of lung cancer: NSE>CEA>ProGRP>CF211 (P<0.05). Although HSP90α and related markers didn’t fit the satisfactory conformance, in terms of the positive rate of diagnosis, it were statistically differences in the diagnostic positive rate between HSP90α and each marker (P<0.01). Reducing HSP90α clinical references in lung cancer combined diagnosis can effectively improve the positive rate of the combined diagnosis.
Conclusion: HSP90α has significant value on early screening and diagnosis of lung cancer. The combined application of HSP90α and related markers can improve the positive rate of early diagnosis of lung cancer effectively.