bluuebunny/crossref_metadata_2025_split huggingface dataset:
A scoping review of harm reduction training for police officers
Authors: Khorasheh Triti , Naraine Renuka , Watson Tara Marie , Wright Amy , Kallio Natalie , Strike Carol 
Published: February 2019

AbstractIssuesPreventable overdose deaths, especially due to opioids, have increasingly been reported worldwide. Expansion of life‐saving harm reduction services is underway with increasing public support in some jurisdictions. However, such services often fall short of reaching people who use drugs (PWUD), in part, due to law enforcement practices that are aligned with punitive drug laws and incongruent with harm reduction principles. One suggested strategy to facilitate police understanding and uptake of practices that are more congruent with harm reduction is to provide police with relevant training.ApproachThis scoping review synthesises English‐language peer‐reviewed and grey literature on harm reduction training programs for police.Key FindingsWe reviewed 31 sources and found that most trainings covered topics related to harm reduction objectives, overdose recognition and response, occupational safety and policing practices. Information was often presented via single‐session, 1‐hour long, slide‐assisted presentations that were integrated into in‐service trainings. Inconsistent throughout the literature was the career stage or position/rank of training audience (e.g. cadets, senior officers, street‐level officers), when and how much training should be provided, and the occupational background of the training facilitator.ImplicationsThe available literature contains significant gaps pertaining to descriptions of training development, design and content specific to facilitating positive police‐PWUD interactions, and formal evaluations. These gaps limit our understanding of what well‐designed trainings may look like, if and how training alters policing practices, and to what extent training completion may lead to improved outcomes.ConclusionGreater research and formal evaluations of harm reduction training for police is recommended.
Systematic review of randomized controlled trials on antibiotic treatment for osteomyelitis in diabetes
Authors: Xing K. , Huang G. , Hua S. , Xu G. , Li M. 
Published: February 2019

AbstractAimTo evaluate the efficacy of antibiotic therapy in osteomyelitis treatment among people with diabetes.MethodsA systematic search of PubMed, EMBASE, AMED, Web of Science, the WHO trial registry, Cochrane library databases, and ClinicalTrials.gov, in addition to hand‐searching, was undertaken in July 2018. Two reviewers independently extracted data. The studies’ methodological quality was assessed using the modified Jadad scale. Descriptive analysis was performed.ResultsSeven randomized controlled trials, with 393 participants in total, were included. The antibiotic regimens, treatments and follow‐up durations varied among the trials. The total scores showed that the overall methodological quality of the seven studies was high, despite two studies showing some flaws in double‐blinding and withdrawals/drop‐outs. Of four studies comparing different antibiotic regimens, three implied a similar remission effect, while one implied that ertapenem ± vancomycin treatment showed a higher remission rate than tigecycline treatment; this conclusion was not robust because of low power and small sample size. In the other three studies, which included two different doses of ciprofloxacin, an antibiotics group and a conservative surgical group, and two durations of the same antibiotic strategy, no significant differences in remission were reported between the groups. No difference was observed in the analyses of microbiological outcomes, superinfections and relapse, except adverse events.ConclusionsThere is no definitive evidence supporting the superiority of any particular antibiotic agent, dose, or administration duration in the treatment of osteomyelitis in diabetes. As the included studies had some flaws and limitations, further research is necessary.
Multimodal prevention of first psychotic episode through N‐acetyl‐l‐cysteine and integrated preventive psychological intervention in individuals clinically at high risk for psychosis: Protocol of a randomized, placebo‐controlled, parallel‐group trial
Authors: Schmidt Stefanie J. , Hurlemann René , Schultz Johannes , Wasserthal Sven , Kloss Christian , Maier Wolfgang , Meyer‐Lindenberg Andreas , Hellmich Martin , Muthesius‐Digón Ana , Pantel Tanja , Wiesner Pia‐Sophie , Klosterkötter Joachim , Ruhrmann Stephan ,   the ESPRIT‐B1 Group
Published: February 2019

AimMeta‐analyses indicate positive effects of both antipsychotic and cognitive‐behavioural interventions in subjects clinically at high risk (CHR) for psychosis in terms of a delay or prevention of psychotic disorders. However, these effects have been limited regarding social functioning and the relative efficacy of both types of interventions remains unclear. Furthermore, neuroprotective substances seem to be a promising alternative agent in psychosis‐prevention as they are associated with few and weak side‐effects.MethodsIn this multi‐centre randomized controlled trial (RCT), we investigate the effects of two interventions on transition to psychosis and social functioning: (a) an integrated preventive psychological intervention (IPPI) including stress‐/symptom‐management and social‐cognitive remediation; (b) N‐acetyl‐l‐cysteine (NAC) as a pharmacological intervention with glutamatergic, neuroprotective and anti‐inflammatory capabilities.ResultsThis is a double‐blind, placebo‐controlled RCT with regard to NAC and a single‐blind RCT with regard to IPPI using a 2 × 2‐factorial design to investigate the individual and combined preventive effects of both interventions. To this aim, a total of 200 CHR subjects will be randomized stratified by site to one of four conditions: (a) IPPI and NAC; (b) IPPI and Placebo; (c) NAC and psychological stress management; (d) Placebo and psychological stress management. Interventions are delivered over 26 weeks with a follow‐up period of 12 months.ConclusionThis paper reports on the rationale and protocol of an indicated prevention trial to detect the most effective and tolerable interventions with regard to transition to psychosis as well as improvements in social functioning, and to evaluate the synergistic effects of these interventions.
Surgical management of an enterocutaneous umbilical fistula caused by an incarcerated Richter's hernia in a one‐year‐old Quarter Horse filly
Authors: Sommerfeld T. C. , Röcken M. , Al Naem M. , Geburek F. 
Published: February 2019

SummaryThis article reports a case of a one‐year‐old Quarter Horse filly with an enterocutaneous fistula resulting from an umbilical hernia since birth, treated successfully by en bloc resection of the hernial sac with the fistula and closure of the ileum with a modified Heineke‐Mikulicz technique. This consisted of closing the intestinal wound transversely to the long axis after excision of the fistula to help preserve a sufficient intestinal lumen and prevent potential stricture formation after longitudinal closure. Umbilical hernias are reported to have an incidence of 0.5–2.0% usually resolve spontaneously. Reducible hernias do not represent a surgical emergency whereas incarcerations should always undergo surgery as soon as possible. Enterocutaneous fistulae occur uncommonly as a result of congenital umbilical herniae that developed spontaneously into Richter's herniae or Littré herniae or they are induced traumatically or iatrogenically after therapeutic attempts. In most cases, enterocutaneous fistulae do not require immediate surgery. However, the excision of the fistula should be scheduled within a few days after diagnosis. In the current case, the owner reported a healthy development of the filly after 1 year without any functional problems. This case represents an example of successful use of the Heineke‐Mikulicz technique to establish an alternative to standard end‐to‐end anastomosis.
Discovery and structural analysis of a phloretin hydrolase from the opportunistic human pathogen Mycobacterium abscessus
Authors: Han Jian‐Ting , Zhang Si‐Ping , Jia Wen‐Juan , Zhang Zhang , Wang Yong , He Yong‐Xing 
Published: February 2019

The family of PhlG proteins catalyses the hydrolysis of carbon‐carbon bonds and is widely distributed across diverse bacterial species. Two members of the PhlG family have been separately identified as 2,4‐diacetylphloroglucinol (2,4‐DAPG) hydrolase and phloretin hydrolase; however, the extent of functional divergence and catalytic substrates for most members of this family is still unknown. Here, using sequence similarity network and gene co‐occurrence analysis, we categorized PhlG proteins into several subgroups and inferred that PhlG proteins from Mycobacterium abscessus (MaPhlG) are likely to be functionally equivalent to phloretin hydrolase. Indeed, we confirmed the hydrolytic activity of MaPhlG towards phloretin and its analog monoacetylphloroglucinol (MAPG), and the crystal structure of MaPhlG in complex with MAPG revealed the key residues involved in catalysis and substrate binding. Through mutagenesis and enzymatic assays, we demonstrated that H160, I162, A213 and Q266, which are substituted in 2,4‐DAPG hydrolase, are essential for the activity towards phloretin. Based on the conservation of these residues, potential phloretin hydrolases were identified from Frankia, Colletotrichum tofieldiae and Magnaporthe grisea, which are rhizosphere inhabitants. These enzymes may be important for rhizosphere adaptation of the producing microbes by providing a carbon source through anaerobic degradation of flavonoids. Taken together, our results provided a framework for understanding the mechanism of functional divergence of PhlG proteins.
Multi‐year carbon budget of a mature commercial short rotation coppice willow plantation
Authors: Morrison Ross , Rowe Rebecca L , Cooper Hollie M. , McNamara Niall P. 
Published: February 2019

AbstractEnergy derived from second generation perennial energy crops is projected to play an increasingly important role in the decarbonization of the energy sector. Such energy crops are expected to deliver net greenhouse gas emissions reductions through fossil fuel displacement and have potential for increasing soil carbon (C) storage. Despite this, few empirical studies have quantified the ecosystem‐level C balance of energy crops and the evidence base to inform energy policy remains limited. Here, the temporal dynamics and magnitude of net ecosystem carbon dioxide (CO2) exchange (NEE) were quantified at a mature short rotation coppice (SRC) willow plantation in Lincolnshire, United Kingdom, under commercial growing conditions. Eddy covariance flux observations of NEE were performed over a four‐year production cycle and combined with biomass yield data to estimate the net ecosystem carbon balance (NECB) of the SRC. The magnitude of annual NEE ranged from −147 ± 70 to −502 ± 84 g CO2‐C m−2 year−1 with the magnitude of annual CO2 capture increasing over the production cycle. Defoliation during an unexpected outbreak of willow leaf beetle impacted gross ecosystem production, ecosystem respiration, and net ecosystem exchange during the second growth season. The NECB was −87 ± 303 g CO2‐C m−2 for the complete production cycle after accounting for C export at harvest (1,183 g C m−2), and was approximately CO2‐C neutral (−21 g CO2‐C m−2 year−1) when annualized. The results of this study are consistent with studies of soil organic C which have shown limited changes following conversion to SRC willow. In the context of global decarbonization, the study indicates that the primary benefit of SRC willow production at the site is through displacement of fossil fuel emissions.
Ocular dialysis disequilibrium—Management of intraocular pressure during hemodialysis of open angle glaucoma: A case report and review of the literature
Authors: Lippold Cassiopia L. , Kalarn Sachin P. , Swamy Ramya N. , Patel Ami M. 
Published: February 2019

AbstractIt has been shown that patients with end‐stage renal disease (ESRD) have an increased risk for changes in intraocular pressure during hemodialysis, or ocular dialysis disequilibrium which can cause pain or discomfort during treatment and lead to decreased vision over time. This is a case of an elderly male with ESRD who was having headaches, nausea, and eye pain during hemodialysis due to increased intraocular pressures. Using a higher sodium prescription resolved his symptoms and normalized his intraocular pressures. This case illustrates that modification in dialysate tonicity can decrease changes in intraocular pressures while patients are on hemodialysis, a vision saving consideration for patients.
Cross‐Sectional Evaluation of the Psychometric Properties of the Headache‐Specific Locus of Control Scale in People With Migraine
Authors: Grinberg Amy S. , Seng Elizabeth K. 
Published: February 2019

ObjectiveThis study aims to investigate the psychometric properties (component structure, reliability, and construct validity) of the Headache‐Specific Locus of Control scale in several clinical migraine populations.BackgroundHeadache‐specific locus of control beliefs may impact a person’s behavioral decisions that affect the likelihood of migraine attack onset, emotional responses to migraine attacks, coping strategies used, and treatment adherence. The 33‐item Headache‐Specific Locus of Control scale is the most widely used measure of locus of control specific to headache yet psychometric evaluations remain limited.MethodsSix hundred and ninety‐five adults with a diagnosis of migraine from 5 different research studies completed cross‐sectional self‐report measures including the Headache‐Specific Locus of Control scale and measures of quality of life and disability (Migraine‐Specific Quality of Life Questionnaire and Migraine Disability Assessment).ResultsFive Headache‐Specific Locus of Control components emerged from Horn’s Parallel Analysis, Minimum Average Partial test, and Principal Component Analysis (eigenvalues: Presence of Internal = 5.7, Lack of Internal = 4.0, Luck = 2.9, Doctor = 2.0, and Treatment = 1.5). The 33 Headache‐Specific Locus of Control items demonstrated adequate internal consistency for total (α = 0.79) and subscale scores (α’s = 0.69 to 0.88). This study found preliminary evidence of convergent validity. For example, Lack of Internal (r = −0.12, P = 0.004), Doctor (r = −0.20, P < .001), and Treatment (r = −0.12, P = .004) beliefs were associated with higher overall migraine‐specific quality of life impairments.ConclusionsThe Headache‐Specific Locus of Control scale is a reliable and valid measure of headache‐specific locus of control. Findings suggest that headache‐specific locus of control is more multidimensional than previous conceptualizations and contribute to our understanding of control beliefs as a potential mechanism for migraine treatment.
Half‐dose clarithromycin‐containing bismuth quadruple therapy is effective and economical in treating Helicobacter pylori infection: A single‐center, open‐label, randomized trial
Authors: Lu Bingyun , Wang Jiamin , Li Jing , Liu Le , Chen Ye 
Published: February 2019

AbstractBackgroundClarithromycin‐containing bismuth quadruple therapy has been recommended as the first‐line therapy for H pylori infection in China. However, its expensive cost and high antibiotic‐related adverse reactions are always haunting us. To find a safer, more cost‐effective, and high eradicative strategy for Helicobacter treatment, we investigated the efficacy of 14‐day bismuth quadruple therapy and different doses of clarithromycin in the first‐line treatment.MethodA total of 210 patients with H pylori infection were recruited and randomly assigned to half‐dose clarithromycin group (esomeprazole 20 mg bid, amoxicillin 1 g bid, clarithromycin 250 mg bid, and bismuth potassium citrate 0.6 g bid) for 14 days or standard‐dose clarithromycin group (esomeprazole 20 mg bid, amoxicillin 1 g bid, clarithromycin 500 mg bid, and bismuth potassium citrate 0.6 g bid) for 14 days. A 13C‐urea breath test (13C‐UBT) was performed at least 4 weeks after treatment. The eradication rate of H pylori, the incidence of side effects, and the cost‐effectiveness of regimens were evaluated in this study.ResultsThe eradication frequencies were 86.67% for both groups in the intention‐to‐treat analysis, while the per‐protocol eradication rates were 91% vs. 91.92% (p=0.817). The incidence of adverse events was higher in standard dose group (54.21% vs. 34.29%; p=0.004), especially bitter taste symptom. There was a higher level of costs per person associated with the standard‐dose group as compared with half‐dose group (￥804.3 vs ￥654.36). The cost‐effectiveness ratio of the half dose was less than that of the standard dose (7.55 vs 9.16 CNY per percent).ConclusionsA 14‐day half‐dose clarithromycin‐containing bismuth quadruple regimen is as effective as the standard bismuth quadruple therapy at eradicating H pylori, which is better tolerated and more economical. (ChiCTR‐ROC‐15007406).
Effects of empagliflozin treatment on cardiac function and structure in patients with type 2 diabetes: a cardiac magnetic resonance study
Authors: Cohen Neale D. , Gutman Sarah J. , Briganti Esther M. , Taylor Andrew J. 
Published: February 2019

AbstractBackgroundThe effects of empagliflozin on cardiac structure and function are not known.AimsTo examine the changes in cardiac structure and function following the addition of empagliflozin in patients with type 2 (T2D) diabetes using cardiac magnetic resonance (CMR) imaging.MethodsTwenty patients attending a specialist diabetes service recommended for treatment with empagliflozin, and 8 control patients with T2D on stable glucose lowering therapy were recruited for cardiac imaging. Participants underwent CMR scans at baseline and 6 months. Inclusion criteria were established T2D, age < 75 years, estimated glomerular filtration rate ≥45 mL/min/1.73 m2.Results17 of 20 in the empagliflozin group, and all of 8 in the control group completed the study. Empagliflozin therapy was associated with reduction in left ventricular end diastolic volume 155 mL (137 mL, 174 mL) at baseline to 145 mL (125 mL, 165 mL) at 6 months, P < 0.01, compared with the control group 153 mL (128 mL, 179 mL) at baseline and 158 mL (128 mL, 190 mL), not significant. There were no differences in measures of left ventricular mass, ejection fraction, heart rate or markers of cardiac fibrosis at baseline and 6 months in either group.ConclusionsThis is the first CMR study to examine the effects of empagliflozin on cardiac function and structure, showing evidence of reduced end diastolic volume. This is likely to reflect change in plasma volume, and may explain the reduced cardiovascular death and heart failure seen in the EMPA‐REG OUTCOME trial.
Wrongdoing and whistleblowing in health care
Authors: Pohjanoksa Johanna , Stolt Minna , Suhonen Riitta , Leino‐Kilpi Helena 
Published: February 2019

AbstractAim(s)To describe healthcare professionals’ experiences of observed wrongdoing and potential whistleblowing acts regarding it. The main goal is to strengthen the whistleblowing process described based on the existing literature and to make it more visible for future research.DesignA descriptive cross‐sectional survey.MethodsData were collected between 26 June 2015–17 July 2015 from the Finnish trade union's membership register, electronically using one open question. A total of 226 healthcare professionals participated providing written narratives, which were analysed using inductive content analysis.FindingsThe whistleblowing process in health care was strengthened, identifying the content of observed wrongdoings and whistleblowing acts regarding them. Three themes were identified: wrongdoing related to patients, healthcare professionals, and healthcare managers. Whistleblowing acts were performed internally, externally, or left undone. Three main paths: internal, external, and no whistleblowing, between an observation of wrongdoing and whistleblowing act were identified.ConclusionThe whistleblowing process should be further developed and ethically effective programmes and interventions should be developed for increasing whistleblowing and preventing wrongdoing in health care.
The existence of a fire‐mediated tree‐recruitment bottleneck in an Asian savanna
Authors: Nguyen Thuy T. , Murphy Brett P. , Baker Patrick J. 
Published: February 2019

AbstractAimA considerable proportion of the global savanna biome has been mis‐classified as forest, especially in Asia. However, the structure and responses of dominant tree species to fire can help to clarify this ambiguity. Here, we examine demographic structure and fire responses of four dominant tree species in a deciduous dipterocarp forest (DDF) of the continental Southeast Asia. We examine whether fire creates a tree‐recruitment bottleneck in the DDF, as in savannas on other continents.LocationYokDon National Park, Vietnam.TaxonDipterocarpus tuberculatus Roxb.; Dipterocarpus obtusifolius Teysm. ex Miq.; Shorea obtusa Wall. ex Blume; Shorea siamensis (Kurz) Miq.MethodsWe measured the size of all 8,288 individuals of the four dominant dipterocarp species in 12 pair study sites. We then applied fire treatments (burnt or unburnt) to the plots and monitored the survival and growth of juveniles five times over the subsequent growing season.ResultsAll four species showed clear indications of a recruitment bottleneck at the sapling stage. Almost all juveniles in the burnt plots suffered aboveground mortality, but 64% resprouted by the end of the following growing season. Compared to large juveniles, small juveniles had a significantly higher probability of aboveground mortality and a more limited ability to resprout. Within 3 months of fire, 43%–93% of individuals had resprouted, and they had recovered 67%–95% of their pre‐fire basal diameter and 43%–94% of their pre‐fire height. At the end of the post‐fire growing season, burnt juveniles experienced virtually no net increase in size; however, juveniles in unburnt plots attained up to 150% of their pre‐fire size.Main conclusionsThe four dominant tree species of the DDF show remarkable similarities in the demographic structures and fire‐responses with savanna tree species on other continents. Our results are consistent with the notion that the DDF is functionally similar to savannas on other continents. Fire appears to act as potent environmental filter of tree species composition in the DDF.
The role of dendritic cells regulated by HMGB1/TLR4 signalling pathway in myocardial ischaemia reperfusion injury
Authors: Xue Jiyang , Ge Hanwei , Lin Zhiyong , Wang Hanlei , Lin Wei , Liu Yong , Wu Guowei , Xia Jie , Zhao Qifeng 
Published: February 2019

AbstractInflammatory response plays an important role in ischaemia reperfusion injury (IRI) through a variety of inflammatory cells. Apart from neutrophils, macrophages and lymphocytes, the role of dendritic cells (DCs) in IRI has been noticed. The study was aimed at investigating whether the high‐mobility group protein box‐1/toll like receptor 4 (HMGB1/TLR4) signalling pathway regulate the migration, adhesion and aggregation of DCs to the myocardium, induce DCs activation and maturation, stimulate the expression of surface costimulatory molecules and participate in myocardial IRI. In vivo, migration, adhesion, and aggregation of DCs was enhanced; the expression of peripheral blood DCs CD80 and CD86, myocardial adhesion molecules were increased; and the infarct size was increased during myocardial ischaemia reperfusion injury myocardial ischemic/reperfusion injury (MI/RI). These responses induced by MI/RI were significantly inhibited by HMGB1 specific neutralizing antibody treatment. Cellular experiments confirmed that HMGB1 promoted the release of inflammatory cytokines through TLR4/MyD88/NF‐κB, upregulated CD80 and CD86 expression, mediated the damage of cardiomyocytes and accelerated the apoptosis. Our results indicate that DCs activation and maturation, stimulate the expression of surface costimulatory molecules by promoting the release of inflammatory factors through NF‐κB pathway and participate in myocardial IRI.