bluuebunny/crossref_metadata_2025_split huggingface dataset:
E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration
Authors: Hollern Daniel P. , Swiatnicki Matthew R. , Rennhack Jonathan P. , Misek Sean A. , Matson Brooke C. , McAuliff Andrew , Gallo Kathleen A. , Caron Kathleen M. , Andrechek Eran R. 
Published: July 2019

AbstractIn prior work we demonstrated that loss of E2F transcription factors inhibits metastasis. Here we address the mechanisms for this phenotype and identify the E2F regulated genes that coordinate tumor cell metastasis. Transcriptomic profiling of E2F1 knockout tumors identified a role for E2F1 as a master regulator of a suite of pro-metastatic genes, but also uncovered E2F1 target genes with an unknown role in pulmonary metastasis. High expression of one of these genes, Fgf13, is associated with early human breast cancer metastasis in a clinical dataset. Together these data led to the hypothesis that Fgf13 is critical for breast cancer metastasis, and that upregulation of Fgf13 may partially explain how E2F1 promotes breast cancer metastasis. To test this hypothesis we ablated Fgf13 via CRISPR. Deletion of Fgf13 in a MMTV-PyMT breast cancer cell line reduces colonization of the lungs in a tail vein injection. In addition, loss of Fgf13 reduced in vitro cell migration, suggesting that Fgf13 may be critical for tumor cells to escape the primary tumor and to colonize the distal sites. The significance of this work is twofold: we have both uncovered genomic features by which E2F1 regulates metastasis and we have identified new pro-metastatic functions for the E2F1 target gene Fgf13.
Long-term, non-anthropogenic groundwater storage changes simulated by three global-scale hydrological models
Authors: Li Bailing , Rodell Matthew , Sheffield Justin , Wood Eric , Sutanudjaja Edwin 
Published: July 2019

AbstractThis study examined long-term, natural (i.e., excluding anthropogenic impacts) variability of groundwater storage worldwide. Groundwater storage changes were estimated by forcing three global-scale hydrological models with three 50+ year meteorological datasets. Evaluation using in situ groundwater observations from the U.S. and terrestrial water storage derived from the Gravity Recovery and Climate Experiment (GRACE) satellites showed that these models reasonably represented inter-annual variability of water storage, as indicated by correlations greater than 0.5 in most regions. Empirical orthogonal function analysis revealed influences of the El Niño Southern Oscillation (ENSO) on global groundwater storage. Simulated groundwater storage, including its global average, exhibited trends generally consistent with that of precipitation. Global total (natural) groundwater storage decreased over the past 5–7 decades with modeled rates ranging from 0.01 to 2.18 mm year−1. This large range can be attributed in part to groundwater’s low frequency (inter-decadal) variability, which complicates identification of real long-term trends even within a 50+ year time series. Results indicate that non-anthropogenic variability in groundwater storage is substantial, making knowledge of it fundamental to quantifying direct human impacts on groundwater storage.
Remote effect of a tropical cyclone in the Bay of Bengal on a heavy-rainfall event in subtropical East Asia
Authors: Arakane Sho , Hsu Huang-Hsiung , Tu Chia-Ying , Liang Hsin-Chien , Yan Zheng-Yu , Lin Shian-Jiann 
Published: July 2019

AbstractTorrential frontal rainfall occurred over Northern Taiwan on June 2, 2017. Prior to this rainfall, tropical cyclone (TC) Mora formed in the Bay of Bengal. This study investigated the triggering effect of TC Mora on the heavy-rainfall system through numerical experiments. The numerical experiments, in which TC Mora was included or excluded in the initial conditions, revealed that TC Mora strengthened the southwesterly winds, which effectively transported tropical warm moist air toward Taiwan, and the cool dry northerly winds to the north of Taiwan. The strengthened southeasterly and northerly winds created a strong frontal system near Taiwan. TC Mora contributed to the heavy frontal rainfall by enhancing tropical–extratropical interaction and vertical coupling in East Asia.
The role of GRHL2 and epigenetic remodeling in epithelial–mesenchymal plasticity in ovarian cancer cells
Authors: Chung Vin Yee , Tan Tuan Zea , Ye Jieru , Huang Rui-Lan , Lai Hung-Cheng , Kappei Dennis , Wollmann Heike , Guccione Ernesto , Huang Ruby Yun-Ju 
Published: July 2019

AbstractCancer cells exhibit phenotypic plasticity during epithelial–mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET) involving intermediate states. To study genome-wide epigenetic remodeling associated with EMT plasticity, we integrate the analyses of DNA methylation, ChIP-sequencing of five histone marks (H3K4me1, H3K4me3, H3K27Ac, H3K27me3 and H3K9me3) and transcriptome profiling performed on ovarian cancer cells with different epithelial/mesenchymal states and on a knockdown model of EMT suppressor Grainyhead-like 2 (GRHL2). We have identified differentially methylated CpG sites associated with EMT, found at promoters of epithelial genes and GRHL2 binding sites. GRHL2 knockdown results in CpG methylation gain and nucleosomal remodeling (reduction in permissive marks H3K4me3 and H3K27ac; elevated repressive mark H3K27me3), resembling the changes observed across progressive EMT states. Epigenetic-modifying agents such as 5-azacitidine, GSK126 and mocetinostat further reveal cell state-dependent plasticity upon GRHL2 overexpression. Overall, we demonstrate that epithelial genes are subject to epigenetic control during intermediate phases of EMT/MET involving GRHL2.
ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK)
Authors: Li Meng-Tian , Liang Jun-Yun , Sun Yi-Ping , Jin Jian , Xiong Yue , Guan Kun-Liang , Yuan Hai-Xin 
Published: July 2019

Abstract
Protein lysine acetylation is one of the major posttranslational modifications (PTMs) with several thousands of proteins identified to be acetylated in mammalian tissues. Mechanistic studies have revealed important functions of acetylation in the regulation of protein function. Much less is known on how the acetyltransferases themselves are regulated. In the current study, we discover that the Elongator protein 3 (ELP3) acetyltransferase is modified by tyrosine phosphorylation. We demonstrate that the anaplastic lymphoma kinase (ALK) is the major tyrosine kinase responsible for ELP3 tyrosine phosphorylation. ELP3 is phosphorylated in tumor cells expressing oncogenic NPM–ALK fusion protein. We further identify Tyr202 as the major ALK phosphorylation site in ELP3. Importantly, the introduction of Y202 phosphorylation mutant ELP3 into ALK-positive tumor cells reduced cell growth and impaired gene expression. Collectively, our study reveals a novel regulatory mechanism for ELP3, provides an example that acetyltransferase itself can be regulated by PTM, and suggests a potential target for ALK-positive cancer therapies.
The Effectiveness of Classroom Vocabulary Intervention for Adolescents With Language Disorder
Authors: Lowe Hilary , Henry Lucy , Joffe Victoria L. 
Published: July 2019

Purpose
Phonological–semantic intervention has been shown to be effective in enhancing the vocabulary skills of children with language disorder in small-group or individual settings. Less is known about vocabulary interventions for adolescents with language disorder in whole-class models of delivery. The current study investigated the effectiveness of phonological–semantic vocabulary intervention for adolescents with language disorder, delivered by secondary school teachers within science lessons.

Method
Seventy-eight adolescents with language disorder, aged 11–14 years, were taught science curriculum words by teachers in class, under 2 conditions: (a) 10 words taught through usual teaching practice and (b) 10 matched words taught using an experimental intervention known as Word Discovery, which embedded phonological–semantic activities into the teaching of the syllabus. Ten similar control words received no intervention. Word knowledge was assessed pre-intervention, postintervention, and follow-up.

Results
At pre-intervention, measures of depth of word knowledge and expressive word use did not differ between usual teaching practice and experimental words. At postintervention, depth of knowledge of experimental words was significantly greater than that of usual teaching practice words. This significant advantage was not maintained at follow-up, although depth of knowledge for experimental words remained significantly higher at follow-up than at pre-intervention. At postintervention, expressive use of experimental words was significantly greater than that of usual teaching practice words, and this significant difference was maintained at follow-up. There was no change in students' depth of knowledge or expressive use of no-intervention words over time, confirming that the findings were not due to maturity or practice effects.

Conclusion
The experimental intervention was more effective than usual teaching practice in increasing the word knowledge of participants. Clinical and teaching implications include the importance of intervening during the adolescent years, with classroom vocabulary intervention being a viable option for collaborative teacher and speech and language therapy/pathology practice.
5 Yearsʼ Experience of a Tertiary Center with Thrombocytopenic Pregnancies: Gestational Thrombocytopenia, Idiopathic Thrombocytopenic Purpura and Hypertensive Disorders of Pregnancy
Authors: Fadiloglu Erdem , Unal Canan , Tanacan Atakan , Portakal Oytun , Beksac Mehmet Sinan 
Published: July 2019

Abstract
Aim To evaluate thrombocytopenic pregnancies including gestational thrombocytopenia (GT), idiopathic thrombocytopenic purpura (ITP), and hypertensive disorders of pregnancy (HDP).
Materials and Methods We evaluated the pregnancy outcomes and laboratory findings of 385 patients diagnosed with GT, ITP, or HDP whose thrombocyte levels were < 150 000/µL.
Results GT, ITP, and HDP were the final diagnoses in 315 (81.8%), 35 (9.1%), and 35 (9.1%) cases, respectively. Patients diagnosed during the 1st trimester and diagnosed with ITP had significantly lower minimal platelet counts during the antenatal period and prior to delivery (p < 0.001; p < 0.001; p < 0.001; p < 0.001). Transfusion of any kind of blood product was given in 9.9% (n = 38) of all cases. Twelve patients had methylprednisolone and/or intravenous immunoglobulin treatments during the antenatal period. All patients who had undergone medical treatment were also found to have ITP. Four out of 385 patients underwent hysterectomy post partum due to refractory hemorrhage. Analysis of newborn platelet levels showed no statistical differences between any of the groups. Despite the lack of statistical significance, the rate of thrombocytopenia in newborns was 50% in patients with severe thrombocytopenia, while rates were 25.6 and 18.1% in patients with moderate and mild thrombocytopenia, respectively.
Conclusion Thrombocytopenic pregnancies must be carefully evaluated with regard to the severity of thrombocytopenia, gestational period at initial diagnosis, and etiology. In particular, patients with ITP must be evaluated carefully as these patients are more likely to require transfusions and have platelet counts < 50 × 103/µl.
Circulating Serum Myonectin Levels in Obesity and Type 2 Diabetes Mellitus
Authors: Li Zhu , Yang Yan-Ling , Zhu Yan-Juan , Li Chen-Guang , Tang Yun-Zhao , Ni Chang-Lin , Chen Li-Ming , Niu Wen-Yan 
Published: July 2019

Abstract
Objective Myonectin is one of the myokines and has gained interest as a potential new strategy to combat obesity and its associated disorders, such as type 2 diabetes mellitus (T2DM).The objective of this study was to investigate circulating serum myonectin levels in nondiabetes and T2DM and elucidate possible relationships between serum myonectin levels and metabolic parameters in patients with T2DM.
Design A total of 362 Chinese patients with T2DM and 100 age- and sex-matched healthy controls were recruited in this study. Clinical characteristics, blood biochemistry, and circulating myonectin levels were measured by enzyme-linked immunosorbent assay.
Results Circulating myonectin levels were significantly decreased in T2DM compared with controls. Obese nondiabetic controls had significantly lower serum myonectin levels compared with lean nondiabetic controls. In diabetic patients, serum myonectin concentrations were significantly negatively correlated with body mass index (BMI), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), C-reactive protein (CRP), hemoglobin A1c (HbA1c), fasting insulin (Fins), the homeostatic model assessment of insulin resistance (HOMA-IR), visceral fat area, and subcutaneous fat area. After adjusting for covariates, multivariate stepwise regression analysis demonstrated that BMI, LDL-C, TG, HOMA-IR, and visceral fat were the main independent predictors of low serum myonectin concentrations.
Conclusions Circulating myonectin levels were decreased in T2DM patients and in obese subjects. Moreover, serum myonectin levels were correlated with metabolic markers of T2DM. These data suggest that myonectin may be a useful marker in predicting the development of obesity and T2DM.
Der physiotherapeutische Takt
Authors: Grafe Marion , Behrens Johann 
Published: July 2019

Zusammenfassung
Hintergrund Die Interaktion zwischen Patienten und Therapeuten gilt als unspezifischer Wirkfaktor in der physiotherapeutischen Behandlung. Neben praktischen, interpersonalen und kommunikativen Fähigkeiten beeinflussen organisatorische Rahmenbedingungen die Interaktion.
Ziel In dieser Arbeit erfolgte eine handlungsfeldspezifische Analyse der Interaktion zwischen Patienten und Therapeuten in ambulanten Physiotherapiepraxen. Dabei wurde der Frage nachgegangen, welche Merkmale die Interaktion in der ambulanten Praxis charakterisieren und welche Bedeutung die Rahmenbedingungen der ambulanten Praxis in diesem Zusammenhang haben.
Methode Die Studie wurde gemäß der Grounded Theory nach Corbin und Strauss konzipiert 1
2. Das Datenmaterial umfasste Videoaufzeichnungen von Behandlungen, Protokolle des lauten Denkens der aufgezeichneten Behandlungen, Feldprotokolle von Beobachtungen und Transkriptionen von Interviews. Nach dem Prinzip des Contrast Samplings wurden nach Rahmenbedingungen und Therapeutenmerkmalen differenzierte Situationen aufgenommen. Das Datenmaterial wurde transkribiert und interpretativ-kodierend ausgewertet. In die Studie waren insgesamt 9 in ambulanten Praxen arbeitende Therapeuten eingeschlossen.
Ergebnisse Der Takt der ambulanten Physiotherapiepraxis wurde ausgehend von der zentralen Anforderung „immer im Takt bleiben“ definiert. Organisatorisch-strukturelle, therapeutisch-inhaltsbezogene und beziehungsbezogene Aufgaben sind Dimensionen dieses Takts. Sie verdeutlichen, dass pauschale Zeitvorgaben einem situationsspezifischen und patientenzentriertem Vorgehen entgegenstehen.
Schlussfolgerung Der Takt der ambulanten Physiotherapiepraxis eröffnet eine Perspektive auf Anforderungen in der ambulanten Praxis. Dieser stellt ein heuristisches Modell dar, welches den gelungenen Umgang mit den Widersprüchlichkeiten beschreibt und insbesondere die situations- und beziehungsbezogenen Aspekte berücksichtigt.
Gillespie's Syndrome with Minor Cerebellar Involvement and No Intellectual Disability Associated with a Novel ITPR1 Mutation: Report of a Case and Literature Review
Authors: Stendel Claudia , Wagner Matias , Rudolph Guenther , Klopstock Thomas 
Published: July 2019

AbstractVariants in the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) gene have been recently identified as a cause of Gillespie's syndrome, a rare inherited condition characterized by bilateral iris hypoplasia, congenital muscle hypotonia, nonprogressive cerebellar ataxia, and intellectual disability. Here, we describe the clinical and genetic findings in a patient who presented with iris hypoplasia, mild gait ataxia, atrophy of the anterior cerebellar vermis but no cognitive deficits. Whole-exome sequencing (WES) uncovered a heterozygous ITPR1 p.Glu2094Lys missense variant, affecting a highly conserved glutamic acid residue for which other amino acid substitutions have already been reported in Gillespie's syndrome patients. Our data expand both the phenotypic and genetic spectrum associated with Gillespie's syndrome and suggest a mutation hotspot on Glu2094.
Diagnostic Considerations in Acute Disseminated Encephalomyelitis and the Interface with MOG Antibody
Authors: Santoro Jonathan D. , Chitnis Tanuja 
Published: July 2019

AbstractAcute disseminated encephalomyelitis (ADEM) is a common yet clinically heterogenous syndrome characterized by encephalopathy, focal neurologic findings, and abnormal neuroimaging. Differentiating ADEM from other demyelinating disorders of childhood can be difficult and appropriate interpretation of the historical, clinical, and neurodiagnostic components of a patient's presentation is critical. Myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases are a recently recognized set of disorders, which include ADEM presentations, among other phenotypes. This review article discusses the clinical diagnosis, differential diagnosis, interpretation of data, and treatment/prognosis of this unique syndrome with distinctive review of the spectrum of MOG antibodies.
Reconciling modern machine-learning practice and the classical bias–variance trade-off
Authors: Belkin Mikhail , Hsu Daniel , Ma Siyuan , Mandal Soumik 
Published: July 2019

Significance
While breakthroughs in machine learning and artificial intelligence are changing society, our fundamental understanding has lagged behind. It is traditionally believed that fitting models to the training data exactly is to be avoided as it leads to poor performance on unseen data. However, powerful modern classifiers frequently have near-perfect fit in training, a disconnect that spurred recent intensive research and controversy on whether theory provides practical insights. In this work, we show how classical theory and modern practice can be reconciled within a single unified performance curve and propose a mechanism underlying its emergence. We believe this previously unknown pattern connecting the structure and performance of learning architectures will help shape design and understanding of learning algorithms.
Transsynaptic Fish-lips signaling prevents misconnections between nonsynaptic partner olfactory neurons
Authors: Xie Qijing , Wu Bing , Li Jiefu , Xu Chuanyun , Li Hongjie , Luginbuhl David J. , Wang Xin , Ward Alex , Luo Liqun 
Published: July 2019

Significance
In the fruit fly olfactory system, 50 classes of olfactory receptor neurons (ORNs) make precise synaptic connections with 50 classes of partner projection neurons (PNs). Identification of wiring molecules here can provide general insight into how neural circuits are assembled during development. This paper reports Fish-lips (Fili), a protein spanning the cell membrane, that regulates specific connections in this circuit. We found that some ORN axons are repelled by Fili present on dendrites of nonpartner PNs, preventing them from targeting inappropriate glomeruli. Similarly, some PN dendrites are repelled by Fili expressed by nonpartner ORNs for their correct targeting. These results suggest that Fili mediates repulsion between axons and dendrites of nonsynaptic partners to ensure precise wiring patterns.
“Vŕba, vŕba, daj mi muža (Sauce, sauce, dame un
hombre…)”
Authors: Kováčová Zuzana , Kováčová Jana 
Published: July 2019

Resumen
La imagen de la mujer en la fraseología tiene varios aspectos y
está diferenciada. La bipolaridad del género masculino y femenino determina la
imagen lingüística y cultural del hombre, la mujer y las interacciones entre
ellos, durante las diferentes etapas de sus vidas. Este estudio se basa
metodológicamente en la aceptación de aspectos reflejados en el significado de
las expresiones idiomáticas. El tema de las relaciones amorosas entre jóvenes es
el más representado en la fraseología eslovaca. La diferencia de edad se
percibía de forma negativa. El matrimonio era tomado muy seriamente; se
consideraba una decisión cuyas consecuencias representarían la felicidad o
infelicidad de la persona. En la fraseología podemos encontrar la imagen de la
mujer y del hombre ideal. La belleza era importante, pero el trabajo duro y la
fidelidad eran los valores prioritarios. El rol de la mujer y el hombre, tanto
en la familia como en la sociedad, han sido determinados tradicionalmente. El
estatus de mujer era influenciado por el derecho romano. El estudio trata de una
corta comparación entre las expresiones idiomáticas eslovacas y españolas sobre
el tema de mujeres, hombres y sus características.
Investigating higher education students’ intercultural readiness for academic mobility
Authors: Aba Diler 
Published: July 2019

AbstractThe present study describes the development and initial empirical testing of a new instrument of intercultural competence. By employing this scale, Turkish Erasmus students’ intercultural sensitivity was examined at a pre-departure stage. The study also investigated whether gender, participation in pre-departure orientation activities and university type (private vs. state) had any influence on the students’ intercultural readiness. Student participants (N = 89) from two state and two private universities in Turkey were involved in the investigation. The data were analyzed using a standard set of psychometric procedures including factor and reliability analyses. For the comparative analyses, T-tests and Anova tests were conducted. Results indicated this new scale to be a reasonable approximation of students’ intercultural readiness for academic mobility. Finally, the participants were found to be quite ready for their Erasmus experience from an intercultural communicative perspective.
The interpreter as a citizen diplomat
Authors: Menzel Birgit 
Published: July 2019

AbstractThe article presents a case of interpretation as a political activity during the Cold War. In the 1980s and 1990s, a grassroots citizen diplomacy movement was initiated by the Californian Esalen Institute, the center of the American Human Potential Movement. In and around its Soviet-American exchange program, numerous individuals, NGOs and organizations established personal relationships and professional exchange with citizens of the two super powers and travelled in both directions. Interpreters had a complex and crucial role in this exchange which was different from both the professional experience of conference and of communal interpreting.
Magnetic properties of the double perovskite compound Sr2YRuO6
Authors: EL Mekkaoui N. , Idrissi S. , Mtougui S. , EL Housni I. , Khalladi R. , Ziti S. , Labrim H. , Bahmad L. 
Published: July 2019

Abstract
We study the magnetic properties of the double perovskite ruthenate compound Sr2YRuO6 using Monte Carlo simulations (MCS). We elaborate the ground state phase diagrams for all possible and stable configurations. The magnetizations and the susceptibilities as a function of temperature for the studied system are also reported. The effects of the exchange coupling interactions and the crystal field are examined and discussed. On the other hand, since the compound Sr2YRuO6 exhibits an antiferromagnetic behavior, we find its Néel temperature,

T

N

≈
31

K

, which is in good agreement with the experimental results in the literature. To complete this study, the hysteresis loops and the coercive field as a function of the external magnetic field are also obtained for fixed values of the physical parameters.