bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Plasma Epstein-Barr Virus DNA in Nasopharyngeal Cancer After Chemoradiation to Identify High-Risk Patients for Adjuvant Chemotherapy: A Randomized Controlled Trial
Authors: Chan Anthony T.C. , Hui Edwin P. , Ngan Roger K.C. , Tung Stewart Y. , Cheng Ashley C.K. , Ng Wai T. , Lee Victor H.F. , Ma Brigette B.Y. , Cheng Hoi C. , Wong Frank C.S. , Loong Herbert H.F. , Tong Macy , Poon Darren M.C. , Ahuja Anil T. , King Ann D. , Wang Ki , Mo Frankie , Zee Benny C.Y. , Chan K.C. Allen , Lo Y.M. Dennis 
Published: July 2018

Purpose The contribution of adjuvant chemotherapy after chemoradiation therapy (CRT) in nasopharyngeal cancer (NPC) remains controversial. Plasma Epstein-Barr virus (EBV) DNA is a potential biomarker of subclinical residual disease in NPC. In this prospective, multicenter, randomized controlled trial, we used plasma EBV DNA to identify patients with NPC at a higher risk of relapse for adjuvant chemotherapy. Patients and Methods Eligible patients with histologically confirmed NPC of Union for International Cancer Control stage IIB to IVB, adequate organ function, and no locoregional disease or distant metastasis were screened by plasma EBV DNA at 6 to 8 weeks after radiotherapy (RT). Patients with undetectable plasma EBV DNA underwent standard surveillance. Patients with detectable plasma EBV DNA were randomly assigned to either adjuvant chemotherapy with cisplatin and gemcitabine for six cycles (arm 1) or observation (arm 2). Patients were stratified for primary treatment (RT v CRT) and stage (II/III v IV). The primary end point was relapse-free survival (RFS). Results Seven hundred eighty-nine patients underwent EBV DNA screening. Plasma EBV DNA was undetectable in 573 (72.6%) and detectable in 216 (27.4%); 104 (13.2%) with detectable EBV DNA were randomly assigned to arms 1 (n = 52) and 2 (n = 52). After a median follow-up of 6.6 years, no significant difference was found in 5-year RFS rate between arms 1 and 2 (49.3% v 54.7%; P = .75; hazard ratio for relapse or death, 1.09; 95% CI, 0.63 to 1.89). The level of post-RT plasma EBV DNA correlated significantly with the hazards of locoregional failure, distant metastasis, and death. Conclusion In patients with NPC with detectable post-RT plasma EBV DNA, adjuvant chemotherapy with cisplatin and gemcitabine did not improve RFS. Post-RT plasma EBV DNA level should be incorporated as the selection factor in future clinical trials of adjuvant therapy in NPC.
Teresa de Jesús
Authors: McGinn Bernard 
Published: July 2018

AbstractTeresa of Ávila has long been noted as one of the most influential Christian mystical teachers for her doctrine on contemplative prayer, mystical graces, and union with God. Her writings, especially the Life and The Interior Castle, have been widely read from the later sixteenth century to the present. Nevertheless, Teresa was far more than an enclosed contemplative totally separated from the world. Rather her biography reveals her as one of the most active and influential women of her time, especially because of her efforts to found seventeen houses of the reform of the Carmelite Order that she initiated in 1562. To understand how Teresa was able to combine contemplation and action it is necessary to investigate her main mystical writings in light of the major stages of her career as a reformer.
Kenosis, Charity, Love
Authors: Pessin Sarah 
Published: July 2018

AbstractThinking with the Christian mystery of kenosis (the self-emptying of God) in relation to divine motions of charity and love, this article sets out to recover a kenotic-mystical element in Greco-Judeo-Islamic Neoplatonisms. After rehearsing the postmetaphysical parameters of the term mystical (and ultimately of the term kenotic-mystical), and after identifying a “deep kenosis” (or “kenosis without kenosis”) in the postmetaphysical kenotics of Vattimo and Marion, the article identifies a ground of “kenosis-charity-love” in the Greco-Islamic Theology of Aristotle, a text whose unique lineage gives insights into Islamic, Greek, and Jewish Neoplatonic encounters with an irruptive and charitable Goodness-without-Being in the shadow of whose outpouring Being pales.
Getting leaves into shape: a molecular, cellular, environmental and evolutionary view
Authors: Maugarny-Calès Aude , Laufs Patrick 
Published: July 2018

ABSTRACTLeaves arise from groups of undifferentiated cells as small primordia that go through overlapping phases of morphogenesis, growth and differentiation. These phases are genetically controlled and modulated by environmental cues to generate a stereotyped, yet plastic, mature organ. Over the past couple of decades, studies have revealed that hormonal signals, transcription factors and miRNAs play major roles during leaf development, and more recent findings have highlighted the contribution of mechanical signals to leaf growth. In this Review, we discuss how modulating the activity of some of these regulators can generate diverse leaf shapes during development, in response to a varying environment, or between species during evolution.
GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system
Authors: Watanabe Shinya , Fujiyama Hiroki , Takafuji Takuya , Kayama Kota , Matsumoto Masaki , Nakayama Keiichi I. , Yoshida Kazumasa , Sugimoto Nozomi , Fujita Masatoshi 
Published: July 2018

ABSTRACT
Glutamate-rich WD40 repeat-containing 1 (GRWD1) is a Cdt1-binding protein that promotes mini-chromosome maintenance (MCM) loading through its histone chaperone activity. GRWD1 acts as a tumor-promoting factor by downregulating p53 (also known as TP53) via the RPL11–MDM2–p53 axis. Here, we identified GRWD1-interacting proteins using a proteomics approach and showed that GRWD1 interacts with various proteins involved in transcription, translation, DNA replication and repair, chromatin organization, and ubiquitin-mediated proteolysis. We focused on the ribosomal protein ribosomal protein L23 (RPL23), which positively regulates nucleolar stress responses through MDM2 binding and inhibition, thereby functioning as a tumor suppressor. Overexpression of GRWD1 decreased RPL23 protein levels and stability; this effect was restored upon treatment with the proteasome inhibitor MG132. EDD (also known as UBR5), an E3 ubiquitin ligase that interacts with GRWD1, also downregulated RPL23, and the decrease was further enhanced by co-expression of GRWD1. Conversely, siRNA-mediated GRWD1 knockdown upregulated RPL23. Co-expression of GRWD1 and EDD promoted RPL23 ubiquitylation. These data suggest that GRWD1 acts together with EDD to negatively regulate RPL23 via the ubiquitin-proteasome system. GRWD1 expression reversed the RPL23-mediated inhibition of anchorage-independent growth in cancer cells. Our data suggest that GRWD1-induced RPL23 proteolysis plays a role in downregulation of p53 and tumorigenesis.
Persistent actin depolarization caused by ethanol induces the formation of multiple small cortical septin rings in yeast
Authors: Homoto Sena , Izawa Shingo 
Published: July 2018

ABSTRACT
Short-term exposure to severe ethanol stress has adverse effects on yeast cells. However, limited information is available on the effects of long-term exposure to severe ethanol stress. In this study, we examined the effects of a long-term treatment with a high ethanol concentration [10% (v/v)] on yeast morphology. We found that long-term severe ethanol stress induced the continuous depolarization of the actin cytoskeleton and hypertrophy in yeast cells, accompanied by the aberrant localization of septins, which formed multiple small cortical rings (MSCRs). The formation of MSCRs was also induced by the continuous depolarization of the actin cytoskeleton caused by a treatment with latrunculin-A, an effective inhibitor of actin polymerization. Unlike the formation of conventional septin rings, the formation of MSCRs did not require Cdc42 and its effectors, Gic1, Gic2 and Cla4. These results provide novel insights into the effects of persistent actin depolarization caused by long-term exposure to severe ethanol stress on yeast cytomorphology.
High dose oral and intravenous rifampicin for improved survival from adult tuberculous meningitis: a phase II open-label randomised controlled trial (the RifT study)
Authors: Cresswell Fiona V. , Ssebambulidde Kenneth , Grint Daniel , te Brake Lindsey , Musabire Abdul , Atherton Rachel R. , Tugume Lillian , Muzoora Conrad , Lukande Robert , Lamorde Mohammed , Aarnoutse Rob , Meya David B. , Boulware David R. , Elliott Alison M. 
Published: July 2018

Background: Tuberculous meningitis (TBM) has 44% (95%CI 35-52%) in-hospital mortality with standard therapy in Uganda. Rifampicin, the cornerstone of TB therapy, has 70% oral bioavailability and ~10-20% cerebrospinal fluid (CSF) penetration. With current WHO-recommended TB treatment containing 8-12mg/kg rifampicin, CSF rifampicin exposures frequently fall below the minimal inhibitory concentration for M. tuberculosis. Two Indonesian phase II studies, the first investigating intravenous rifampicin 600mg and the second oral rifampicin ~30mg/kg, found the interventions were safe and resulted in significantly increased CSF rifampicin exposures and a reduction in 6-month mortality in the investigational arms. Whether such improvements can be replicated in an HIV-positive population remains to be determined. Protocol: We will perform a phase II, open-label randomised controlled trial, comparing higher-dose oral and intravenous rifampicin with current standard of care in a predominantly HIV-positive population. Participants will be allocated to one of three parallel arms (I:I:I): (i) intravenous rifampicin 20mg/kg for 2-weeks followed by oral rifampicin 35mg/kg for 6-weeks; (ii) oral rifampicin 35mg/kg for 8-weeks; (iii) standard of care, oral rifampicin 10mg/kg/day for 8-weeks. Primary endpoints will be: (i) pharmacokinetic parameters in plasma and CSF; (ii) safety. We will also examine the effect of higher-dose rifampicin on survival time, neurological outcomes and incidence of immune reconstitution inflammatory syndrome. We will enrol 60 adults with suspected TBM, from two hospitals in Uganda, with follow-up to 6 months post-enrolment. Discussion: HIV co-infection affects the bioavailability of rifampicin in the initial days of therapy, risk of drug toxicity and drug interactions, and ultimately mortality from TBM. Our study aims to demonstrate, in a predominantly HIV-positive population, the safety and pharmacokinetic superiority of one or both investigational arms compared to current standard of care. The most favourable dose may ultimately be taken forward into an adequately powered phase III trial. Trial registration: ISRCTN42218549 (24th April 2018)
Channels of Impact: User Reviews When Quality Is Dynamic and Managers Respond
Authors: Chevalier Judith A. , Dover Yaniv , Mayzlin Dina 
Published: July 2018

We examine the effect of managerial response on consumer voice in a dynamic quality environment. We argue that the consumer is motivated to write reviews not only because reviews may impact other consumers, but because reviews may impact the management and the quality of the service. We examine this empirically in a scenario in which reviewers receive a credible signal that the service provider is listening. Specifically, we examine the “managerial response” feature allowed by many review platforms. We hypothesize that managerial responses will stimulate reviewing activity and, in particular, will stimulate negative reviews that are seen as more impactful. This effect is further heightened because managers respond more and in more detail to negative reviews. Using a multiple-differences specification, we show that reviewing activity and particularly negative reviewing is indeed stimulated by managerial response. Our specification exploits comparison of the same hotel immediately before and after response initiation and compares a given hotel’s reviewing activity on sites with review response initiation to that on sites that do not allow managerial response. We also explore the mechanism behind the effect using an online experiment. Data and the online appendix are available at https://doi.org/10.1287/mksc.2018.1090 .
Dynamic Agency and Endogenous Risk-Taking
Authors: Wong Tak-Yuen 
Published: July 2018

I study a continuous-time principal–agent model in which a multitasking agent engages in unobserved risk-taking. Risk-taking creates short-term profits but also increases the chance of large losses. The optimal contract incentivizes excessive risk-taking when the agent has insufficient skin in the game. Moreover, if the low effort is not too value-destroying and the private benefit of shirking is low enough, the principal can eliminate risk-taking by implementing the low effort. However, with variable project scale, addressing the risk-taking incentives by downsizing projects is not optimal. The implementation of the optimal contract shows that risk management should take agency problems into account. Complete hedging against downside risks provides incentives for the agent to gamble. This paper was accepted by Gustavo Manso, finance.
Winners, Losers, and Facebook: The Role of Social Logins in the Online Advertising Ecosystem
Authors: Krämer Jan , Schnurr Daniel , Wohlfarth Michael 
Published: July 2018

Social logins, such as “Log in with Facebook,” improve a website’s user experience and therefore enjoy great popularity among content providers (CPs) and users alike. Moreover, they also enable the social network and the CPs to share data, which individually improves their ability to place targeted advertising. On the basis of a game-theoretic model that offers a microfoundation for CPs’ competition for advertisements, on the one hand, and CPs’ competition for users, on the other hand, we demonstrate the strategic effects of social logins in the online advertising ecosystem. We fully characterize the market conditions under which social logins are offered and adopted, and when the adoption is actually profitable for the CPs. In particular, we show across several model extensions that the voluntary adoption of the social login may yield a prisoner’s dilemma outcome for the CPs. The online appendix is available at https://doi.org/10.1287/mnsc.2017.3012 . This paper was accepted by Chris Forman, information systems.
It Is Time to Get Some Rest
Authors: Baucells Manel , Zhao Lin 
Published: July 2018

We introduce the fatigue disutility model. Set in continuous time, the model formalizes the notion that fatigue accumulates with effort, decays with rest, and produces an increase in marginal instant disutility. The model is meant to be prescriptive, although it rationalizes several anomalies observed in time preference. Under very general conditions, the most efficient temporal profile of effort exhibits a high-low-high pattern. We consider a variant whereby marginal productivity decreases with fatigue, and we examine the optimal management of fatigue and productivity under various scenarios. We also reexamine the beneficial role of breaks in reducing fatigue. We bring the model to the data and provide a calibration that favorably predicts the speed profiles observed in swimming competitions. Data are available at https://doi.org/10.1287/mnsc.2017.3018 . This paper was accepted by Han Bleichrodt, decision analysis.
Inventário do significado do trabalho: explorando evidências de validade no setor de edificações
Authors: Pinheiro Rafaele De Araújo , Bendassolli Pedro Fernando , Borges Livia De Oliveira 
Published: July 2018

Este artigo teve como objetivo explorar características de validade do Inventário do Significado do Trabalho (IST), bem como explorar a relação dos tipos de significados e as variáveis sócio-ocupacionais. Para tanto, aplicamos o IST a 402 trabalhadores do setor de edificações em duas capitais do Nordeste brasileiro. Analisamos as respostas dos participantes com a técnica Smallest Space Analisys (SSA). Obtivemos cinco tipos de atributos valorativos e sete de atributos descritivos do trabalho, que se revelaram associados à idade, ao tempo de trabalho em edificações e ao tempo de trabalho no emprego atual.
Data protection is changing − the new general data protection regulations (GDPR)
Authors: Hemmings Nicholas , Noar Joseph 
Published: July 2018

Abstract: The General Data Protection Regulations (GDPR) govern the use of personal data within the European Union as from 25th May 2018. This supersedes the legislation of the Data Protection Act (DPA). Whilst it has many similarities to the DPA, it has significant enhancements that require active engagement to ensure compliance. It is a requirement for practices to appoint a Data Protection Officer, pay the Information Commissioners Office (ICO) fee, update their privacy notices, create written contracts between controllers and processors, identify and document the lawful basis for processing data, and comply with the rights of individuals. CPD/Clinical Relevance: Data protection regulations have changed as part of EU legislation. These changes applied from 25th May 2018 and are applicable to all.
Snatching an archive: Gay citation, queer belonging and the production of pleasure in RuPaul’s Drag Race
Authors: Shetina Michael 
Published: July 2018

Abstract
Since its 2009 debut, RuPaul’s Drag Race (2009–present) has been a site of contact between the worlds of subcultural performance and media industries. Of particular interest to critics has been its uneasy placement of queer networks of belonging within the competitive, individualist space of a reality competition series. Building upon recent scholarship on reality television and affect, this article analyses the transfer of pleasures among RuPaul, her queens and viewers by focusing on Snatch Game, a recurring challenge in which competitors impersonate gay icons. It argues that, through these performances of queer citation, Snatch Game makes a case for the continuing importance of queer mediations of dominant culture – often in ways that are at odds with the show’s neo-liberal ethos. In doing so, Snatch Game documents not only a canon of gay icons but also the networks of pleasure and belonging fabricated through their queer circulation.
The privilege of knowing better: Female millennial demographics and the representation of homophobia on teen TV
Authors: Peters Wendy 
Published: July 2018

Abstract
The 2010–11 seasons of 90210 (2008–13), Degrassi (2010–15), Glee (2009–15) and Pretty Little Liars (2010–17) represent homophobia as arising from closeted teens, cisgender male ‘jocks’, racialized characters and immigrants. Rather than locating homophobia and heteronormativity within the social fabric and minds of all who have been steeped in American and Canadian hegemonic beliefs, homophobic characters are framed as rare, anachronistic and out-of-step with the seemingly post-homophobia ethos they exist within. Drawing on media trade publications, I place these patterns for representing homophobia in their market context, arguing that profit motives encourage representations of gay teens and homophobia that suggest homophobic beliefs are the domain of ‘others’, apart from the privileged viewer of teen TV: affluent, educated, female, white and non-white millennials aged 18–34. The target viewers are invited to see themselves as innocent and enlightened in relation to homophobic others, while prescribing a cure to homophobia that emphasizes individual change over social change.
Masculine exposure: Transgressive representations of the male nude in contemporary dance and editorial fashion photography
Authors: Whited Brandon 
Published: July 2018

Abstract
The male body as subject/object has taken various forms across artistic disciplines, cultures and points throughout history. Previously, the image of a virile, muscled Adonis prevailed as an idealized hegemonic masculinity. A look at contemporary visual and performing arts of the twenty-first century reveals a progressive shift towards a more inclusive range of multiple masculinities and representations of maleness, queering conventional depictions of the male form. This creative interrogation of normative gender expression on the stage and screen and in print has the potential to challenge binary constraints on gender and expand the visibility of queer, marginalized expressions of masculinity. This article employs queer gaze theory and close readings of performance as text to examine works by fashion photographer Steven Klein and choreographer John Jasperse to evaluate how the personal history, creative methodology and artistic outlook of each contemporary artist play a role in questioning traditional masculine representations via the transgressive nude male body.
Filmmaking in Central America: An overview
Authors: Cortés María Lourdes 
Published: July 2018

Abstract
Since the turn of the twenty-first century, Central American audio-visual production has increased in an unprecedented manner. In the 1990s, the entire region only produced and exhibited one feature-length film, El silencio de Neto/Neto’s Silence (Argueta, 1994), yet in the last seventeen years more than two hundred fiction films have been made and shown in Central America. It is only in the last few years, however, that some of these films have attracted international interest in the form of funding and distribution or have created their own structures for these. This article therefore seeks to answer the question of how and why Central American film industries have been revived since 2000, considering the differing approaches to production and distribution employed by regional organizations, national governments and individual directors.
Can María speak?: Interpreting Ixcanul/Volcano (2015) from a decolonial perspective
Authors: Alfaro Córdoba Amanda 
Published: July 2018

Abstract
This article explores, describes and analyses the material, linguistic and cultural framework in which the central conflict in Ixcanul/Volcano (Bustamante, 2015) and its mise-en-scène operate, considering the film as an example of an intertextual practice that succeeds in connecting oral and dramatic traditions to a filmic register. By analysing how the film aims to be realistic and locate itself within a contemporary Guatemalan context, this study argues that, due to the film’s political intentions, themes and intended audience, Ixcanul challenges several power structures that preclude decolonial dialogue in the country. Furthermore, by describing how the subaltern subject, María, endures and resists strategies of invisibilization, I read Ixcanul in light of analytical tools drawn from postcolonial and decolonial frameworks to disentangle the structures of domination – the coloniality of power – represented in the film.
Forging her path with her own fists: Autonomy and contradictions of age, class and gender in Florence Jaguey’s La Yuma/Yuma (2010)
Authors: Murillo Bértold Salas 
Published: July 2018

Abstract
Florence Jaugey’s La Yuma/Yuma (2010) was the first feature-length fiction film made in Nicaragua, by a Nicaraguan, in over two decades. The film presents Yuma, a young woman from a marginal neighbourhood who finds her answer to the challenges of a hostile environment through boxing. The film employs the narrative and stylistic norms of boxing movies in order to radically subvert them. Jaguey’s mise-en-scène, which includes documentary style elements, the narrative that privileges sociological characterization and intersectional connections and the film’s presentation to the Nicaraguan public as an ‘authentic’ story, encourage the examination of the social tensions represented in La Yuma. Through an analysis of film form, the article examines the representation of intersectional discrimination. The film’s conclusion is ambiguous: at the same time as it recognizes a series of irreparable divisions in Nicaraguan society it also indicates hope for a better future for its protagonist thanks to her optimism and newly conquered autonomy, as well as incorporating humour and the ludic into the narrative solution.